bluuebunny/crossref_metadata_2025 huggingface dataset:
Experimental Investigation of Terminal Shock/Boundary-Layer Interaction with and without Upstream Lateral Confinement
Authors: Wang Zi-Yun , Sun Shu , Zhang Yue , Tan Hui-Jun , Chen Liang
Published: September 2022

A generic external-compression inlet test model is designed and fabricated to investigate the flow characteristics of terminal shock/boundary-layer interaction for inlet applications with and without upstream lateral confinement. When the leading edge of the sidewall is positioned 150 mm upstream of the duct entrance, the bifurcation height of the [Formula: see text] shock, the centerline separation length, and the pressure rise ratio at [Formula: see text] are close to reported values in the literature, although the corner separation herein is minor as compared with previous experiments with thick sidewall boundary layers. However, when the leading edge of the sidewall is aligned with the duct entrance, an obvious increase in the bifurcation point height can be observed, and an increase in centerline separation can be inferred from schlieren photographs. The significantly intensified separation is verified directly by surface oil flow visualization. In addition, the focus previously present in the corner region is replaced by a reattachment node located near the junction region of the bottom plate and sidewall leading edge. The intensification of the separation is attributed to a local high-pressure region caused by the impingement of the postshock subsonic flow onto the sidewalls.
Processing on Curcuma longa waste oil-diesel blends for using as better alternative to diesel fuel
Authors: Karunanidhi SanjeeviPrakash , Decruz Arul Marcel Moshi Antony Joseph , Kasimani Ramesh
Published: September 2022

Technology advancements are growing in an exponential rate. Automobile sector is getting developed day by day where modern innovations are viewed with different features for the human society. Inspite of having various renewable energy sources, the demand for the fossil fuels still exists for meeting out the requirements of the growing application sides. In the present work, different blends of Curcuma longa waste neat oil samples have been prepared and mixed with diesel at different volume fractions. Nano metal oxide particles such as cerium oxide and Nano Egg Shell Powder (NESP) have been added with the prepared fuel samples in order to achieve better evaporation, atomization, better air-fuel mixing, considerable reduction in ignition delay and best flame sustainability nature. The prepared waste oil samples have been tested under four different loading conditions such as 30, 60, 90 and 120 N. The performance characteristics such as Brake Thermal Efficiency (BTE), Brake Specific Fuel Consumption (BSFC), Exhaust Gas Temperature (EGT), % of carbon monoxide emission, % of carbon dioxide emission, % of hydrocarbon emission and % of NOX emission have been measured for the tested blends. From the results, the optimal sample which exhibits improved desirable characteristics has been suggested. Grey Relational Analysis (GRA) has also been used as a multi objective optimization tool in order to find out the best composition of the Curcuma longa waste oil – diesel blend in order to achieve better desirable properties. ANOVA technique has been used to identify the most influencing input factor in achieving better characteristics for the oil blends.
Dural metastasis from prostate carcinoma mimicking tuberculum sellae meningioma: A case report
Authors: Kobayashi Masaaki , Sasagawa Yasuo , Nakada Satoko , Kohda Yukihiko , Nakada Mitsutoshi
Published: September 2022

Background:

Prostate carcinoma rarely metastasizes to the central nervous system. However, when it does, a dural lesion is a common and possible misdiagnosis of meningioma. Here, we describe a case of a 77-year-old man with dural metastasis from prostate carcinoma of the tuberculum sellae.

Case Description:

The patient was diagnosed with prostate carcinoma 7 years previously and was well-controlled by hormone therapy. He was incidentally found to have a suprasellar tumor and underwent endoscopic endonasal transsphenoidal surgery because of rapid tumor growth and worsening visual impairment. Since his serum prostate-specific antigen (PSA) level was within the normal range, malignant meningioma was suspected based on the magnetic resonance imaging (MRI) and the course. However, the pathological findings revealed dural metastasis from prostate carcinoma. He received radiation therapy, and the tumor disappeared on MRI. His visual impairment improved without recurrence. This case report highlights that dural metastasis of the tuberculum sellae arose despite the patient’s PSA level being within the normal range, and a single metastasis to the dura was found.

Conclusion:

In patients with a history of prostate carcinoma or older men, careful follow-up considering the possibility of metastasis is required when a dural lesion is found.
De novo dural arteriovenous fistula after mechanical thrombectomy for cerebral venous thrombosis: A case report
Authors: Kida Satoru , Neki Hiroaki , Hiramatsu Hisaya , Kamio Yoshinobu , Makita Ippei , Shiraishi Yuki , Kurozumi Kazuhiko
Published: September 2022

Background:

Although the relationship between dural arteriovenous fistula (dAVF) and cerebral venous thrombosis (CVT) has been reported, the etiology has not been clarified. Here, we report a case of de novo dAVF after mechanical thrombectomy for CVT and discuss the underlying mechanism.

Case Description:

A 61-year-old woman presented with a gradually worsening headache and was diagnosed with severe CVT. Mechanical thrombectomy was performed for the CVT because of progressive neurological deterioration despite anticoagulation therapy. Two years after the initial treatment, angiography revealed a de novo dAVF with a direct shunt of the left convexity cortical vein. Transarterial embolization with Onyx was performed and the shunt was completely obliterated.

Conclusion:

In this report, we describe a case of de novo dAVF with CVT that was treated with mechanical thrombectomy. Even if CVT improves with mechanical thrombectomy, we must be aware of the occurrence of de novo dAVF.
Reversible microscale assembly of nanoparticles driven by the phase transition of a thermotropic liquid crystal
Authors: Fhionnlaoich Niamh Mac , Schrettl Stephen , Tito Nicholas B. , Yang Ye , Nair Malavika , Serrano Luis A. , Harkness Kellen , Silva Paulo Jacob , Frauenrath Holger , Carter W Craig , Stellacci Francesco , Guldin Stefan
Published: September 2022

The arrangement of nanoscale building blocks into patterns with microscale periodicity is challenging to achieve via self-assembly processes. Here, we report on the phase transition-driven collective assembly of gold nanoparticles in a thermotropic liquid crystal. A temperature-induced transition from the isotropic to the nematic phase leads to the assembly of individual nanometre-sized particles into arrays of micrometre-sized aggregates, whose size and characteristic spacing can be tuned by varying the cooling rate. This fully reversible process offers hierarchical control over structural order on the molecular, nanoscopic, and microscopic level and is an interesting model system for the programmable patterning of nanocomposites with access to micrometre-sized periodicities.
Reaction Environment Impacts Charge Transfer But Not Chemical Reaction Steps in Hydrogen Evolution Catalysis
Authors: Tang Bryan Y. , Bisbey Ryan P. , Lodaya Kunal M. , Toh Wei Lun , Surendranath Yogesh
Published: September 2022

Heterogeneous electrocatalysis involves elementary chemical and charge transfer reaction steps, with the kinetics of each step contributing to the overpotential requirement at a given reaction rate. Typical experiments report on the aggregate rate-overpotential profile with no information about the relative contributions from charge transfer and chemical steps. For the hydrogen evolution reaction (HER), the applied overpotential can be partitioned into a charge transfer overpotential, the overpotential necessary to drive proton-coupled electron transfer (PCET) to and from the surface, and a chemical overpotential, corresponding to a change in surface H activity. Reaction conditions can affect either or both the charge transfer and chemical components. Herein, we employ a Pd membrane double cell to spatially separate the charge transfer and chemical reactions steps of HER catalysis, enabling quantification of the chemical and charge transfer overpotential. We further analyze how each depend on pH, and the introduction of HER poisons and promoters. We find that for a given rate of H2 release, the chemical overpotential is constant across diverse reaction environments whereas the charge transfer overpotential is strongly sensitive to reaction conditions. These findings suggest that reaction condition dependent-HER efficiencies are driven predominantly by changes to the kinetics of charge transfer rather than the chemical reactivity of surface H.
Large dataset of molecular and reaction energies from multi-level quantum chemical methods
Authors: Nandi Surajit , Vegge Tejs , Bhowmik Arghya
Published: September 2022

Well curated extensive datasets have have helped spur intense molecular machine learning(ML) method development activities over last few years encouraging non-chemists to be part of the effort as well. QM9 dataset is the one of the benchmark database for small molecules with molecular energies based on B3LYP functional. G4MP2 based energies of these molecules were published later. To enable a widely variety of ML tasks with QM9 molecules, in this article, we introduce a new dataset with QM9 molecule energies estimated with 76 different DFT functionals and three different basis sets (228 energy numbers for each molecule). We additionally enumerated all possible A <-> B molecular conversions within the QM9 dataset and provide the reaction energies based on these 76 functionals, and basis sets. Lastly, we also provide the bond changes for all the 162 million reactions with the dataset to enable structure and bond based reaction energy prediction tools based on ML.
Unified Access to Pyrimidines and Quinazolines Enabled by N-N Cleaving Carbon Atom Insertion
Authors: Hyland Ethan , Kelly Patrick , McKillop Alexander , Dherange Balu , Levin Mark
Published: September 2022

Given the ubiquity of heterocycles in biologically active molecules, transformations with the capacity to modify such molecular skeletons with modularity remain highly desirable. Ring expansions that enable interconversion of privileged heterocyclic motifs are especially interesting in this regard. As such, the known mechanisms for ring expansion and contraction determine the classes of heterocycle amenable to skeletal editing. Herein, we report a reaction that selectively cleaves the N-N bond of pyrazole and indazole cores to afford pyrimidines and quinazolines, respectively. This chlorodiazirine-mediated reaction provides a unified route to a related pair of heterocycles that are otherwise typically prepared by divergent approaches. Mechanistic experiments and DFT calculations support a pathway involving pyrazolium ylide fragmentation followed by cyclization of the ring-opened diazahexatriene intermediate to yield the new diazine core. Beyond enabling access to valuable heteroarenes from easily prepared starting materials, we demonstrate the synthetic utility of skeletal editing in the synthesis of a Rosuvastatin analog as well as in an aryl vector-adjusting direct scaffold hop.
¿A qué juega Netflix? La convergencia de contenidos a través de los videojuegos en su estrategia multietapa
Authors: Gómez-García Salvador , Vicent-Ibáñez Mireya
Published: September 2022

La decisión de Netflix de incorporar juegos en su catálogo tradicional de contenidos en noviembre de 2021 se percibe como una apuesta cuya concreción resulta aún incierta. Esta investigación explora los primeros meses de este nuevo servicio tratando de determinar cómo se ha producido la incorporación de este contenido en la plataforma, qué tipo de entretenimiento se ofrece y cómo se localiza dentro de la estrategia de contenidos de la compañía, así como la recepción por parte de sus usuarios y suscriptores. La metodología se fundamenta en una triangulación metodológica cuantitativa y cualitativa recogida en una ficha de análisis para cada uno de los juegos de la muestra (n=14).

Los resultados reflejan que, en estos primeros meses, la oferta de juegos se dirige a ofrecer un entretenimiento liviano y reforzar el valor de la suscripción a Netflix, aunque comienzan a apuntar juegos en una lógica transmedia o que sirven como refuerzo de otros contenidos de la plataforma. Además, el nuevo conjunto de datos que Netflix obtiene de sus suscriptores a través del visionado de su plataforma y la interacción con el nuevo tipo de contenido puede suponer una baza importante para el futuro de la compañía.
Charan, R. Repensar la ventaja competitiva. Nuevas reglas para la era digital
Authors: Salazar Velarde Mela
Published: September 2022

Un mercado de cambios rápidos, desarrollo tecnológico y competencia intensa hacen que las compañías se replanteen su ventaja competitiva - tema central de este libro - que ya no parece estar en los activos ni en las marcas establecidas, como señala el autor, sino en quien tiene la preferencia del consumidor y la mantiene a través de la innovación continua y una cultura orientada a la acción.
Methionine uptake via the SLC43A2 transporter is essential for regulatory T-cell survival
Authors: Saini Neetu , Naaz Afsana , Metur Shree Padma , Gahlot Pinki , Walvekar Adhish , Dutta Anupam , Davathamizhan Umamaheswari , Sarin Apurva , Laxman Sunil
Published: September 2022

Cell death, survival, or growth decisions in T-cell subsets depend on interplay between cytokine-dependent and metabolic processes. The metabolic requirements of T-regulatory cells (Tregs) for their survival and how these are satisfied remain unclear. Herein, we identified a necessary requirement of methionine uptake and usage for Tregs survival upon IL-2 deprivation. Activated Tregs have high methionine uptake and usage to S-adenosyl methionine, and this uptake is essential for Tregs survival in conditions of IL-2 deprivation. We identify a solute carrier protein SLC43A2 transporter, regulated in a Notch1-dependent manner that is necessary for this methionine uptake and Tregs viability. Collectively, we uncover a specifically regulated mechanism of methionine import in Tregs that is required for cells to adapt to cytokine withdrawal. We highlight the need for methionine availability and metabolism in contextually regulating cell death in this immunosuppressive population of T cells.
Development of a control path VHDL code generator for hardware development
Authors: Marcus Lloyde George , Brandon Joseph
Published: September 2022

The Very High-Speed Integration Circuit HDL (VHDL) is widely used to implement digital electronic systems. The VHDL language can be difficult to learn, so it is necessary to simplify and speed up the process of implementing digital electronic components through a hardware description with a minimal understanding of the VHDL language. This paper entails the design and development of a Graphical User Interface (GUI) capable of generating VHDL code for ControlPaths using specified state transition tables and state diagrams. This application was created using the Matrix Laboratory (MATLAB). Application Builder as the development platform. After development, the system went through unit testing and integration testing, after which acceptance testing was carried out. The results of the acceptance tests showed that the software is very effective in quickly generating VHDL code for ControlPaths.
Bilua Changes: Culture Contact and its Consequences, a Study of the Bilua of Vella Lavella in the British Solomon Islands
Authors:   , McKinnon John McLachlan
Published: September 2022

 Human geography along with history, anthropology, economics and other  social sciences concerned with the changing inter-relationships between  man and the environment, regardless of the level of generalisatlon used,  have a responsibility to focus attention on areas of study that will  enhance our understanding of the practical problems of our day. It was  this point of view that led to the collection and interpretation of the  material presented in this dissertation. The research was concerned with  the general problems of rural development.  The specific region studied was centred on the relatively prosperous  vlllages of Uzamba and Maravari on the east coast of Vella Lavella ln  the British Solomon Islands Protectorate (B.S.I.P.) and was limited to  the area in which the villagers had a traditional interest. 
The Spatiality of Women’s Struggle within Porto’s Residents’ Movement during Portuguese Revolutionary Process (1974-75)
Authors: Ruivo Pereira Catarina
Published: September 2022

This paper explores the role of women’s struggle within residents’ movements in the production and transformation of space in Porto during the PREC (the Portuguese Revolutionary Process of 1974-1976), analysing the spaces where these movements started, the issues they focused on, and how it related and acted within explicit and implicit views of family and gender relations in institutional approaches to housing development. It also considers how these were mirrored in housing policy options and design paradigms. In this way, by shifting the focus to women’s struggle at the grassroots, looking at those who were both the recipients of houses and actors of an ongoing struggle, this research explores the intersection between class and gender in the processes of housing and urban development.
Windowish Practices, Unreadable Backgrounds and Raw Semiotics. Tracing Minor Architectures and Ecologies of Signs in Women’s Writing
Authors: Jalón Oyarzun Lucía
Published: September 2022

Minor architectures can be defined as an open set of spatial practices and know-hows based on the agency of bodies. While these practices escape representation, codification or measurement, they have a fertile relation with literature. After framing this relationship, we analyze the work of three women writers (Carmen Martín Gaite, Ali Smith and Toni Morrison) to unveil them as minor spatial and material practitioners. While they have not been trained as architects many women throughout history have practiced and organized space in meaningful and wise ways, and they have become aware of minor spatial knowledges resting at the core of what architecture can be (and do). By inventing forms of embodied writing and material inscription, they have expanded a minor repertoire of spatial practices.
LUCÍA C. PÉREZ-MORENO (ed.) - Perspectivas de género en la arquitectura
Authors: González-Fernández Irene
Published: September 2022

Lucía C. Pérez-Moreno (ed.)Perspectivas de género en la arquitecturaPrimer encuentro. Madrid: Abada Editores, 2018. 160 pp. Tapa blanda. Idioma: español. 15 €ISBN 978-84-17301-13-2Segundo encuentro. Madrid: Abada Editores, 2019. 216 pp. Tapa blanda. Idioma: español. 17 €ISBN 978-84-17301-51-4Tercer encuentro. Madrid: Abada Editores, 2021. 232 pp. Tapa blanda. Idioma: español. 17 €ISBN 978-84-19008-00-8
ZAIDA MUXÍ MARTÍNEZ (coord.) - Antología de pensamientos feministas para arquitectura
Authors: Benedet Veronica
Published: September 2022

Zaida Muxí Martínez (coord.)Antología de pensamientos feministas para arquitecturaBarcelona: Universitat Politècnica de Catalunya, 2022. 475 pp. Digital acceso abierto. Idioma: españolISBN 978-84-9880-966-4
MIGUEL FERNÁNDEZ MAROTO - Urbanismo y evolución urbana de Valladolid (1979-2012). Del proyecto reformista a la hegemonía de lo inmobiliario
Authors: De la Cal Nicolás Pablo
Published: September 2022

Miguel Fernández MarotoUrbanismo y evolución urbana de Valladolid (1979-2012). Del proyecto reformista a la hegemonía de lo inmobiliarioValladolid: Ediciones Universidad de Valladolid, 2021. 336 pp. Tapa blanda. Idioma: españolISBN 978-84-1320-149-8
MANUEL MARTÍN HERNÁNDEZ - La casa en la arquitectura moderna | JOSEP MARIA MONTANER - La arquitectura de la vivienda colectiva
Authors: Soler Montellano Agatángelo
Published: September 2022

Manuel Martín HernándezLa casa en la arquitectura modernaBarcelona: Reverté, 2014. 400 pp. Tapa blanda. Idioma: español. 27,50 €ISBN 978-84-291-2124-7

Josep Maria MontanerLa arquitectura de la vivienda colectivaBarcelona: Reverté, 2015. 305 pp. Tapa blanda. Idioma: español. 23,50 €ISBN 978-84-291-2126-1
Rapid increase in neuroinvasive West Nile virus infections in humans, Italy, July 2022
Authors: Riccardo Flavia , Bella Antonino , Monaco Federica , Ferraro Federica , Petrone Daniele , Mateo-Urdiales Alberto , Andrianou Xanthi D , Del Manso Martina , Venturi Giulietta , Fortuna Claudia , Di Luca Marco , Severini Francesco , Caporali Maria Grazia , Morelli Daniela , Iapaolo Federica , Pati Ilaria , Lombardini Letizia , Bakonyi Tamas , Alexandra Olivia , Pezzotti Patrizio , Perrotta Maria Gabriella , Maraglino Francesco , Rezza Giovanni , Palamara Anna Teresa ,   Italian Arbovirus Surveillance network
Published: September 2022

As in 2018, when a large West Nile virus (WNV) epidemic occurred, the 2022 vector season in Italy was marked by an early onset of WNV circulation in mosquitoes and birds. Human infections were limited until early July, when we observed a rapid increase in the number of cases. We describe the epidemiology of human infections and animal and vector surveillance for WNV and compare the more consolidated data of June and July 2022 with the same period in 2018.
ASSOCIATED RATIO IN ARCHITECTONY OF THE NOVEL BY H. TIUTIUNNYK “ZAVIAZ”
Authors: Likhachova Olesya
Published: September 2022

The article deals with the motive analysis in the work of G. Tiutiunnyk, the connection between the motive and the plot in the novel “Zaviaz” is updated. The purpose of the article is an updated, methodologically pluralistic,
multilevel analysis of the poetics of the prose of H. Tiutiunnyk in the organic interconnection and interaction with such macrostructures as the conceptual and dialogic nature of the conflict of the work, as a plot and «philosophy of composition»; an updated interpretation (on the phenomenological and hermeneutic
levels) of the work of the writer’s prose “archetypal plot” and the role of large and small “associative fields”, their “binary pairs” in the process of implementation and self-deployment of the composition. It was in this context that the subject of the analysis was the novel “Zaviaz of H.Tiutiunnyk. Emphasis is placed
on the existential perception of the author. It is characterized the binary pairs that grow rapidly, pulsating, generating all the other, new and unexpected dynamic bonds, images, symbols, associative crossings, dialogical positions and their circulation; in fact, it is this self-motion of all the structures in the work that
is the essence of the internal self-deployment of the composition; they — in dynamics — are the key, supporting, semantically and figuratively charged nuclei, in the process of splitting distinguishing the conceptual and compositional energy of the work. It is noted that associative areas and their dynamic connections in the prose of the writer are deeply thought out, deliberately organized and designed: from the real life and the spiritual world of the author, his characters — again aimed at the core of the same real life.
Evaluation of facility warehouse performance in a logistics company with Copras and Topsis methods
Authors: ER Merve , AVCI Selen , ALADAĞ Zerrin
Published: September 2022

Logistics processes are one of the most important elements among the cost items in companies. The operational treatment of logistics companies directly influences the efficiency of the business. Performance evaluation in the logistics companies is important in terms of sustainability of the operation and measuring the sustainability trend. In this study, facility performance that depending on years, in a logistics company has analyzed comparatively with COPRAS (Complex Proportional Assessment) and TOPSIS (Technique for Order of Preference by Similarity to Ideal Solution) methods, which are among the Multi-Criteria Decision Making (MCDM) techniques. The criteria have determined as operational error, customer complaints, accident frequency rate, absence, turnover rate, training rate, overtime, staff productivity, input productivity, output productivity and on-time dispatch performance. The weights of these criteria have calculated with the Analytical Hierarchy Process (AHP), which is also a MCDM method. Thus, we have compared five years consisting of nine periods and have made various evaluations.
Crystal structure of the system of (1-y)(BiFeO3)-y(Ba1-xSrxTiO3) solid solution.
Authors: Zheludkevich D. V. , Latushko S. I. , Silibin M. V. , Chobot A. N. , Sysa A. V. , Neklyudov K. N. , Chobot G. M. , Karpinsky D. V.
Published: September 2022

The crystal structure of the system of (1-y)(BiFeO3)-y(Ba1-xSrxTiO3)  (0 ≤ x ≤1; 0,2 ≤ y ≤ 0,4) solid solutions was studied based on the X-ray diffraction data and the scanning electron microscopy results. The obtained results have allowed determining the concentration ranges of a single-phase structural state, as well as the regions of coexistence of two structure phases. It is shown that an increase in the concentration of the dopant ions leads to a decrease in rhombohedral distortions. The structure of the compounds with y = 0.25-0.33 is characterized by the coexistence of the rhombohedral and pseudocubic phases. Further chemical doping leads to the transformation of the structure; it becomes single-phase and has a cubic symmetry.  Splitting of the reflections specific to the rhombohedral phase completely disappears for the compounds with y = 0.35; 0.40. Particular attention is paid to the analysis of the structure of solid solutions in the region of the concentration phase transition. The evolution of crystallite morphology was determined as a function of the type of structure distortions and dopants concentration.
Interaction of recombinant human lactoferrin and SARS-CoV-2 virus to heparin-protein conjugate
Authors: Semenov D. A. , Vashkevich I. I. , Vladyko A. S. , Sviridov O. V.
Published: September 2022

The advantages of the complex of recombinant human lactoferrin (rhLF) with europium ions have been used to establish quantitative parameters of specific interaction of rhLF with immobilized heparin-protein conjugate as a model of cell-surface heparan sulfate proteoglycans. Heparin coupled through terminal formyl by reductive amination to an inert protein was adsorbed through the protein part in the wells of a polystyrene microplate. The rhLF–Eu3+ complex obtained from native rhLF contains 0.8 mol of lanthanide ion per mol of protein (40 % saturation level). Equilibrium in the heterophase binding system is established within 1 min at room temperature, and the calculated association constant of the rhLF-heparin complex is 2.1 × 107 M–1. The reversible and saturable character of binding rhLF labeled by Eu3+ at the active site to heparin was confirmed by the transition of rhLF–Eu3+ into the liquid phase when a 1000-fold molar excess of unlabeled rhLF was added to the system. Based on the affinity of rhLF for glycosaminoglycan, a blocking effect of this protein on the binding of the SARS-CoV-2 virus to the immobilized heparin-protein conjugate that imitates proteoglycan on the host cell surface was revealed. Pretreatment of the adsorbed conjugate with a solution of rhLF (10 µg per well) reduces the specific binding of 100 ng of viral particles added to the well by approximately 80 %. The presented results allow one, in particular, to evaluate the integrity of the structure and activity of rhLF as a possible substance in food supplements and pharmaceuticals and may be useful in developing combined drugs for corona virus infection.
Natural diketones as potential covalent ligands for SARS-CoV-2 proteins: an in silico docking study
Authors: Faletrov Ya. V. , Staravoitava V. A. , Pozniak H. I. , Shkumatov V. M.
Published: September 2022

Our computer-aided protein-ligand docking test using Autodock Vina software allowed to reveal the potential of few α- and β-diketones from plants and alternative living organisms as covalent ligands for few proteins of coronavirus SARS-CoV-2 – a causative agent of COVID-19. It has been established that values for energy of binding (docking score, Ebind, kcal/mol) less than –7.5 and for distances of ligands’ carbonyl groups to side chain nitrogens of arginine residues of some coronaviral enzymes within 0.4 nm have been true for β-diketones 6-gingerdione (Pubchem code CID162952), 8-gingerdione (CID14440537), tetrahydrocurcumine (CID124072) as well as α-diketone wallitaxane E (CID132967478). The in silico revealed interactions are interesting to be verified in vitro and they point out a possibility of investigation of the compounds and related natural materials as tools for struggle against coronaviral infections.
Cardioprotective efficiency of postconditioning using L-lactate during ischemia-reperfusion of myocardium in young and old rats under conditions of the systemic action in the animal body of the blocker of M-cholinoreactive systems atropine
Authors: Chepelev S. N. , Vismont F. I. , Goubkin S. V.
Published: September 2022

Myocardial protection from ischemic and reperfusion injury is an important task of modern experimental and clinical medicine. This type of damage is a key link in the pathogenesis of the coronary heart disease and, above all, acute myocardial infarction – a socio-economically significant disease that is one of the main causes of disability and mortality of the adult population in the Republic of Belarus.

The aim of the study was to elucidate the cardioprotective efficiency of postconditioning (Post) using L-lactate during ischemia–reperfusion of myocardium in young and old rats under the conditions of systemic action in the body of animals of the blocker of M-cholinergic systems atropine.

In experiments on rats, it was found that Post using L-lactate has an infarct-limiting effect during ischemia–reperfusion of myocardium in both young and old animals, however, under the conditions of systemic action of atropine (2 mg/kg), this effect was partially preserved only in old rats. Apparently, the activity of peripheral M-cholinergic systems is important in the mechanisms of implementation of the cardioprotective effects of Post using L-lactate in young, but not in old rats.
Dynamics of neonatal morbidity in children with large body weight
Authors: Prylutskaya V. A. , Sukalo A. V.
Published: September 2022

Preservation of the health of each child is the basis of the activities of the service for protection of motherhood and childhood. The article presents the results of analysis of the structure of births by body weight. A retrospective analysis of the incidence of full-term children with large (4000 g or more) body weight at birth in Minsk for the period 2004–2019 was carried out according to state statistics. It was revealed that the average proportion value of large newborns was 10.1 ± 0.07 %. During the analyzed period, the incidence rate of newborns with a birth weight of 4000 g or more decreased (278.4 ‰ in 2004, 177.8 ‰ in 2019, the average long-term growth rate was ‒2.95 %). When analyzing the morbidity structure of newborns, the leading place was occupied by individual conditions that occur in the perinatal period, 87.2 ± 0.80 %. In the analyzed time interval of 2004–2019, diseases with the highest degree of association with biggest birth weight were other birth trauma (OR = 2.30 (2.19–2.43), p < 0.001), endocrine and metabolic disorders (OR = 2.19 (2.04–2.34), p < 0.001).
Morphofunctional state of the liver of male Wistar rats during diet-induced obesity and its correction
Authors: Basalai A. A. , Kuznetsova T. E. , Mityukova T. A. , Poluliakh O. Y. , Chudilovskaya K. N. , Kastsiuchenka M. S. , Shcherbakov Ya. V. , Khrustaleva T. A. , Hubkin S. V.
Published: September 2022

Nonalcoholic fatty liver disease is the most common pathological condition inherent in obesity, which is associated with excessive accumulation of lipid droplets in hepatocytes, which, in turn, leads to the impaired functioning of the organ.

The aim of the study is to investigate the effect of diet-induced obesity, as well as variants of its correction on morphofunctional characteristics of the liver tissue and biochemical indices of blood serum of male rats.

The experiments were carried out on sexually mature male Wistar rats. The experiment consisted of two stages of 8 weeks each: 1) modeling obesity using a high-caloric diet (HCD); 2) obesity correction with the evaluation of the contribution of several experimental approaches: abandonment of HCD with a transition to a standard balanced diet and moderate physical activity in the form of running on a treadmill against the background of different caloric intakes.

Keeping the rats for 16 weeks on HCD led to the formation of visceral obesity, fatty liver dystrophy, dyslipidemia, and disbalance of enzymatic processes – hyperbilirubinemia on the background of the reduced activity of aspartate aminotransferase and alanine aminotransferase in blood serum. The histoarchitectonics of the liver was partially restored with the preservation of inflammatory infiltration of the organ upon return to the standard diet. A return to the standard diet promoted a partial restoration of the liver histoarchitectonics with the preservation of inflammatory infiltration of the organ. When switching to a standard diet in combination with the moderate physical activity, a more pronounced restoration of the liver histostructure and signs of the active regeneration of the organ were observed.

The most complete variant of correction of fatty hepatosis is the transition to a balanced diet in combination with the moderate physical activity.
Digital economy, digitalization of agricultural production in the Republic of Belarus: peculiarities of terminology
Authors: Еremenko P. S. , Balysh A. I. , Boyeva N. P.
Published: September 2022

Examines and summarizes some issues of the development and implementation of the digital economy and IT technologies in agricultural production in order to enhance the export potential of the agroindustrial complex  of  the  Republic  of  Belarus,  the  need  for  digitalization  of  agricultural  facilities at the present stage of economic activity. An attempt has been made to clarify the terminological meaning of the concept of  “digital economy” as a part of the branch of economic science.
Foreign experience of assessment and forecasting the effectiveness of the functioning of agroindustrial production branches in the conditions of integrated cooperative-integration structures
Authors: Kosova A. L.
Published: September 2022

Provides a systematic analysis of foreign experience (Argentina, Brazil, Russian Federation, USA, countries of EU) to assess and forecast the fac­tors of balanced development of agroindustrial production. Different types of agribusiness models are systematized, depending on the specialization and providing strengthening of vertical integration, integration of marketing and logistics concepts, expansion of product sales channels.
A segurança contra incêndio de edificações tombadas pelo patrimônio histórico e cultural – um desafio à conservação e restauro da Catedral Metropolitana de Campinas
Authors: Belle Andrezza Tavares
Published: September 2022

Neste artigo pretende-se analisar as possíveis soluções alternativas as medidas de segurança contra incêndio padronizadas para os projetos de edificações atuais, mas restritas as edificações tombadas
Hydrogel application in the germination and growth of Zea mays and Solanum lycopersicum seedlings
Authors: Domenico Prisa  , Giacomo Guerrini
Published: September 2022

Research goal: This article presents the results of a research project aimed at demonstrating the effects and benefits of using an organic ingredient, hydrogel (Hydro Start), that can improve the germination and growth of Zea mays and Solanum lycopersicum seedlings. Materials and Methods: Experiments began in April 2022 and were conducted in the greenhouses of CREA-OF in Pescia (PT) on seeded plants of Zea mays and Solanum lycopersicum. Seeds were placed in pots with different hydrogel capsules to determine if there were any effects on plant germination and growth. Agronomic analysis of the seeds and plants, microbiological analysis, and substrate evaluation were also conducted. Results and Discussion: The experiment showed that the use of hydrogel can improve the quality and hardiness of the sown plants of Zea mays and Solanum lycopersicum. In general, the improvement in average germination time and plant growth was proportional to the number of hydrogel capsules placed in the substrate at the time of sowing; this also influenced the microbial colonisation of the soil. Studies show that the water retained in the hydrogel provides a water reservoir in the soil that can increase the efficiency of water uptake by plants. Mixing superabsorbent materials (hydrogels) with soils or growing media can significantly increase the water-holding capacity of the soil. This water is available to plants for a longer period of time, making them more resilient, especially when transplanting. In addition, incorporating hydrogels into the soil or growing media allows for improved germination, plant growth, and nutrient and water uptake. Conclusions: Research shows that hydrogels can be used in a variety of ways due to their ability to retain water. These innovations can also ensure and promote plant survival under dry conditions. Further experiments are currently underway to evaluate hydrogels in tree species germination, transplanting, and acclimation.
A review of the diversity of lichens and what factors affect their distribution in the neotropics
Authors: Lakhnarayan Kumar Bhagarathi  , Gyanpriya Maharaj  , Phillip N. B. DaSilva  , Gomathinayagam Subramanian
Published: September 2022

The purpose of this paper is to review published literature on the diversity of lichens and the factors that affect its distribution in the neotropics. The systematic method was used to research works of literature on “Diversity of lichens and what factors affect their distribution in the neotropics.” A total of forty-nine research papers published between the years 1996 to 2021 was selected and utilized for this review. The results obtained was presented in tables. A subjective approach was then used to select the subtopics: lichens and their impact- benefits and importance. In this paper, twelve (12) neotropical countries were evaluated and a grand total of four hundred twenty-seven (427) lichens species of lichens from fifty-eight (58) lichen families were presented. Lichen distribution and habitats, diversity of lichens and factors that affect the distribution of lichens in the neotropics were also discussed. The published papers established that lichens have a rich diversity globally, they have many benefits and importance, they are widely distributed across the landscape and are found in a wide range of habitats. Many abiotic factors such as temperature, pH, humidity, moisture, latitude, topography, light availability and anthropogenic activities by human beings e.g., pollution and deforestation play a heavy influence on lichens and their distribution in the neotropics as well as globally. More studies should be done in the neotropics since data is limited and in demand.
Management of spontaneous spinal epidural abscess: A case report
Authors: Alngar DJIMRABEYE  , Moussa ELMI SAAD  , Michèle Yolande MOUNE  , Mustapha HEMAMA  , Nizare EL FATEMI  , Moulay Rachid EL MAAQILI
Published: September 2022

Background: Spinal epidural abscess (SEA) is a rare but severe pyogenic infection of the epidural space. Case presentation: A 60-year-old female with a history High Blood Pressure, Chronic Renal Failure and the non-surgical descending aortic aneurysm was hospitalized 10 days before its symptoms in the intensive care unit for treatment of acute infective endocarditis caused by Staphococcus aureus. She presented 24 hours before a lower limb motor weakness, bladder and bowel dysfunction (urinary and anal incontinence).MRI spine with gadolinium demonstrating an epidural contrast-enhancing mass extending from mid Th10 to Th12 left-side with infiltration of the pedicles and extension to the soft tissues and is most consistent with epidural abscess. Within the next few hours the patient underwent decompressive laminectomy (level Th10-Th12) and surgical evacuation of the abscess. The post-operative cultures from the abscess were positive for Staphylococcus- aureus. Intravenous antibiotics were continued, and active neurorehabilitation was initiated. Immediate improvement of the paralysis and sphincter function was observed as a result of the surgical decompression. Conclusion: The incidence of spinal epidural abscess is increasing with the aging of the population and the frequency of immunocompromising diseases. The most common causative agent is Staphylococcus. Aureus. The signs and symptoms of epidural abscess are non-specific. Empiric antibiotic therapy and emergency surgical decompression improve the prognosis.
Development of an Adherence to Anticoagulant Therapy Scale: A Validity and Reliability Study
Authors: KANKAYA Eda Ayten , BİLİK Özlem
Published: September 2022

Purpose: Anticoagulants are an important group of drugs used by many patients with different diseases. There are general adherence scales that measure adherence to treatment in the literature. However, the correct use of the drug alone is not sufficient for adherence with warfarin therapy. To develop Anticoagulant Therapy Adherence Scale for use in patients on

warfarin and to examine psycholinguistic and psychometric properties.

Methods: The research was of a methodological and consisted of 170 patients. The validity of the scale was tested by using content validity, explanatory and confirmatory

factor analysis. The reliability of the scale was examined by utilizing item-total scale

correlations and Cronbach’s alpha.

Results: After the scale items were created, opinions were received from twenty

experts and content validity indexes were found to be above 0.80. In the explanatory

factor analysis, a 3-factor structure with factor loads between 0.30 and 0.81 was

obtained. Fit indices obtained in the confirmatory factor analysis were as follows: χ2 =

181.116, df = 116 χ2/df value 1.561, Root Mean Square Error of Approximation

(RMSEA) = 0.058, Comparative Fit Index (CFI): 0.88 and Goodness Fit Index (GFI):

0.88. Item-total scale correlation coefficients were found to range between 0.57 and

0.25. The Cronbach's alpha reliability coefficient was 0.74 for the overall scale and

0.63, 0.77 and 0.65 for its subscales.

Conclusions: ATAS was found to be a valid and reliable measurement tool in Turkish population. The scale can be used by healthcare professionals to evaluate patients' use of warfarin in a standard way.
Analyzing Hospital High Length of Stay Outliers in Turkey
Authors: YIGIT Pakize , AYDIN Sabahattin , GÜLER Hasan
Published: September 2022

Purpose: The aim of this study is to examine length of stay (LOS) outliers by analyzing hospital administrative database.

Material and Methods: The Turkish Ministry of Health DRG grouper database was utilized to obtain hospital administrative data on discharges for 15 training and research hospitals in 2012. For each diagnosis-related group (DRG), the geometric mean plus two standard deviations were calculated to identify outliers. Analyses were conducted using descriptive statistics and logistic regression using generalized estimating equations (GEE).

Results: High LOS outliers found to be 4.4 % of the cases, they were responsible for 24.50 percent of all discharge days. Alcohol, drug use disorders, burns, and diseases of the ear, nose, mouth, and throat were the factors that had the greatest impact on high LOS outliers, according to the multivariate model.

Conclusion: A quarter of all inpatient days are made up of LOS outliers. Burns, neonate cases, and alcohol/drug use issues should all be carefully evaluated. In order to improve clinical quality and effectively manage hospital resources, hospital administrators and health policy makers should take length of stay outliers into consideration.
Electrical Properties of PAN/PMMA Blends Doped with Lithium Salts
Authors: Almuswy Raad Hashem , Ahmad A.Hasan
Published: September 2022

Polymer blended electrolytes of various concentrations of undoped PAN/PMMA (80/20, 75/25, 70/30, 65/35 and 60/40 wt%) and doped with lithium salts (LiCl, Li2SO4H2O, LiNO3, Li2CO3) at 20% wt have been prepared by the solution casting method using dimethylformamide as a solvent. The electrical conductivity has been carried out using an LCR meter. The results showed that the highest ionic conductivity was 2.80x10-7 (Ω.cm)-1 and 1.05x10-1 (Ω.cm)-1 at 100 kHz frequency at room temperature for undoped (60% PAN + 40% PMMA) and (80% PAN + 20% PMMA) doped with 20%wt Li2CO3 composite blends, respectively. It was found from the measurements of the A.C conductivity of undoped (PAN+PMMA) and doped with different lithium salts in the frequency range (1kHz-100kHz) that A.C conductivity follows empirical laws σa.c(ω)=Aωs, where (s) is (are) located between (0.501-2.054). The frequency-dependent dielectric constant at room temperature for various composites exhibited that because of interfacial space charge polarization, the dielectric constant has a large value. The fluctuation of dielectric loss with the addition of various kinds of lithium salts and frequency-dependent dielectric loss were shown and discussed.
Las palmeras en las fuentes documentales: diversidad, usos, prácticas y valoraciones en el Noreste de la Argentina
Authors: De la Cruz Jaime Alejandro , Doumecq María Belén , Stampella Pablo Cesar
Published: September 2022

Introducción y objetivos: Las palmeras (Arecaceae) son uno de los elementos más conspicuos del Noreste de la Argentina (NEA) ocupando un lugar central en los paisajes y cosmovisiones locales (M´bya, agricultores familiares). El objetivo de este trabajo es registrar la diversidad, usos, valoraciones y prácticas de manejo de las palmeras y palmares registradas en las fuentes documentales. También analizar los procesos de cambio y continuidad, a fin de comprender la construcción del paisaje de palmares de la región.
M&M: Desde la etnobotánica histórica se analizaron tres tipos de fuentes documentales: diarios y manuscritos de los Jesuitas (s. XVIII), diarios de viajeros tempranos (primera mitad del s. XIX) y diarios de viajeros y naturalistas tardíos (fines del s. XIX y principios del XX), que recorrieron el NEA y zonas aledañas.
Resultados: Se registraron 31 nombres locales de Arecaceae que corresponden a siete especies y 37 categorías de uso (i.e. alimentarios, construcciones). Algunos de los usos típicos de los guaraníes quedan relegados a la bibliografía jesuítica, mientras que aquellos relacionados con el ganado son mencionados por viajeros y naturalistas. La valoración de las palmeras es siempre positiva entre los diferentes grupos estudiados y las prácticas de manejo (i.e. recolección, recolección mediante tala y tolerancia) están vinculadas con los principales usos registrados.
Conclusiones: Se puede observar a través de las fuentes documentales la importancia de las palmeras para las comunidades locales así como algunos procesos de cambio y continuidad en las especies mencionadas, usos y prácticas según los tres tipos de fuentes.