bluuebunny/crossref_metadata_2025 huggingface dataset:
Tutorial for $DESIGN in NONMEM: Clinical trial evaluation and optimization
Authors: Bauer Robert J. , Hooker Andrew C. , Mentre France
Published: September 2021

This NONMEM tutorial shows how to evaluate and optimize clinical trial designs, using algorithms developed in design software, such as PopED and PFIM 4.0. Parameter precision and model parameter estimability is obtained by assessing the Fisher Information Matrix (FIM), providing expected model parameter uncertainty. Model parameter identifiability may be uncovered by very large standard errors or inability to invert an FIM. Because evaluation of FIM is more efficient than clinical trial simulation, more designs can be investigated, and the design of a clinical trial can be optimized. This tutorial provides simple and complex pharmacokinetic/pharmacodynamic examples on obtaining optimal sample times, doses, or best division of subjects among design groups. Robust design techniques accounting for likely variability among subjects are also shown. A design evaluator and optimizer within NONMEM allows any control stream first developed for trial design exploration to be subsequently used for estimation of parameters of simulated or clinical data, without transferring the model to another software. Conversely, a model developed in NONMEM could be used for design optimization. In addition, the $DESIGN feature can be used on any model file and dataset combination to retrospectively evaluate the model parameter uncertainty one would expect given that the model generated the data, particularly if outliers of the actual data prevent a reasonable assessment of the variance‐covariance. The NONMEM trial design feature is suitable for standard continuous data, whereas more elaborate trial designs or with noncontinuous data‐types can still be accomplished in optimal design dedicated software like PopED and PFIM.
Deployment of a change‐level software defect prediction solution into an industrial setting
Authors: Eken Beyza , Tufan Selda , Tunaboylu Alper , Guler Tevfik , Atar Rifat , Tosun Ayse
Published: September 2021

Applying change‐level software defect prediction (SDP) in practice has several challenges regarding model validation techniques, data accuracy, and prediction performance consistency. A few studies report on these challenges in an industrial context. We share our experience in integrating an SDP into an industrial context. We investigate whether an “offline” SDP could reflect its “online” (real‐life) performance, and other deployment decisions: the model re‐training process and update period. We employ an online prediction strategy by considering the actual labels of training commits at the time of prediction and compare its performance against an offline prediction. We empirically assess the online SDP's performance with various lengths of the time gap between the train and test set and model update periods. Our online SDP's performance could successfully reach its offline performance. The time gap between the train and test commits, and model update period significantly impacts the online performance by 37% and 18% in terms of probability of detection (pd), respectively. We deploy the best SDP solution (73% pd) with an 8‐month time gap and a 3‐day update period. Contextual factors may determine the model performance in practice, its consistency, and trustworthiness. As future work, we plan to investigate the reasons for fluctuations in model performance over time.
Tackling the obesity crisis
Authors: Kirby Roger
Published: September 2021

In this editorial, Professor Roger Kirby, Editor‐in‐Chief for Trends in Urology and Men's Health, discusses the health costs of rising obesity rates in the UK.
Surgical management of azoospermia
Authors: Yassin Musaab , Tharakan Tharu , Scrimgeour Gemma , Minhas Suks
Published: September 2021

Azoospermia is the absence of sperm in the ejaculate; men with the condition require testicular sperm extraction and assisted reproductive technology (ART) to father children. This review focuses on the surgical management of azoospermia.
Diagnosis and management of erectile dysfunction
Authors: Bromby Adam , Modgil Vaibhav , Pearce Ian
Published: September 2021

Erectile dysfunction is common and may signal vascular disease, so a cardiovascular risk assessment is important for these patients. Thorough counselling is needed along with discussion of all treatment options at an early stage to facilitate shared decision making.
New solutions for an Eshelby inclusion of arbitrary shape in a plane or two jointed half‐planes
Authors: Wang Xu , Schiavone Peter
Published: September 2021

New analytical solutions are derived for Eshelby's problem of an inclusion of arbitrary shape undergoing uniform in‐plane eigenstrains in a plane or in one of two bonded half‐planes. The simply‐connected domain occupied by the inclusion is described by a conformal mapping function that maps the interior of the inclusion onto the interior of the unit circle in the image plane. Elementary expressions of the elastic fields in the exterior of the inclusion and the mean stress inside the thermal inclusion are obtained. Typical examples of epitrochoidal, Booth's lemniscate, hypotrochoidal and generalized Booth's lemniscate thermal inclusions are presented to demonstrate the new solutions.
Stochastic Inflation at NNLO
Authors: Cohen Timothy , Green Daniel , Premkumar Akhil , Ridgway Alexander
Published: September 2021

Abstract

Stochastic Inflation is an important framework for understanding the physics of de Sitter space and the phenomenology of inflation. In the leading approximation, this approach results in a Fokker-Planck equation that calculates the probability distribution for a light scalar field as a function of time. Despite its successes, the quantum field theoretic origins and the range of validity for this equation have remained elusive, and establishing a formalism to systematically incorporate higher order effects has been an area of active study. In this paper, we calculate the next-to-next-to-leading order (NNLO) corrections to Stochastic Inflation using Soft de Sitter Effective Theory (SdSET). In this effective description, Stochastic Inflation manifests as the renormalization group evolution of composite operators. The leading impact of non-Gaussian quantum fluctuations appears at NNLO, which is presented here for the first time; we derive the coefficient of this term from a two-loop anomalous dimension calculation within SdSET. We solve the resulting equation to determine the NNLO equilibrium distribution and the low-lying relaxation eigenvalues. In the process, we must match the UV theory onto SdSET at one-loop order, which provides a non-trivial confirmation that the separation into Wilson-coefficient corrections and contributions to initial conditions persists beyond tree level. Furthermore, these results illustrate how the naive factorization of time and momentum integrals in SdSET no longer holds in the presence of logarithmic divergences. It is these effects that ultimately give rise to the renormalization group flow that yields Stochastic Inflation.
Aryl hydrocarbon receptor (AHR) functions in infectious and sterile inflammation and NAD+-dependent metabolic adaptation
Authors: Bock Karl Walter
Published: September 2021

Aryl hydrocarbon receptor (AHR) research has shifted from exploring dioxin toxicity to elucidation of various physiologic AHR functions. Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is known to exert cellular stress-mediated sterile inflammatory responses in exposed human tissues but may be lethal in sensitive species. Inflammation can be thought of as the extreme end of a spectrum ranging from homeostasis to stress responses (sterile inflammation) and to defense against infection (infectious inflammation). Defense against bacterial infection by generation of reactive oxygen species has to be strictly controlled and may use up a considerable amount of energy. NAD+-mediated energy metabolism adapts to various inflammatory responses. As examples, the present commentary tries to integrate responses of AHR and NAD+-consuming enzymes (PARP7/TiPARP, CD38 and sirtuins) into infectious and stress-induced inflammatory responses, the latter exemplified by nonalcoholic fatty liver disease (NAFLD). TCDD toxicity models in sensitive species provide hints to molecular AHR targets of energy metabolism including gluconeogenesis and glycolysis. AHR research remains challenging and promising.
Open pancreaticoduodenectomy: setting the benchmark of time to functional recovery
Authors: Marchegiani Giovanni , Perri Giampaolo , Andrianello Stefano , Masini Gaia , Brentegani Giacomo , Esposito Alessandro , Bassi Claudio , Salvia Roberto
Published: September 2021

Purpose

No accepted benchmarks for open pancreaticoduodenectomy (PD) exist. The study assessed the time to functional recovery after open PD and how this could be affected by the magnitude of midline incision (MI).

Materials and methods

Prospective snapshot study during 1 year. Time to functional recovery (TtFR) was assessed for the entire cohort. Further analyses were conducted after excluding patients developing a Clavien-Dindo ≥ 2 morbidity and after stratifying for the relative length of MI.

Results

The overall median TtFR was 7 days (n = 249), 6 days for uncomplicated patients (n = 124). A short MI (SMI, < 60% of xipho-pubic distance, n = 62) was compared to a long MI (LMI, n = 62) in uncomplicated patients. The choice of a SMI was not affected by technical issues and provided a significantly shorter TtFR (5 vs 6 days, p = 0.002) especially for pain control (4 vs. 5 days, p = 0.048) and oral food intake (5 vs. 6 days, p = 0.001).

Conclusion

Functional recovery after open PD with MI is achieved within 1 week from surgery in half of the patients. This should be the appropriate benchmark for comparison with minimally invasive PD. Moreover, PD with a SMI is feasible, safe, and associated with a faster recovery.
Early Post-operative Feeding: An Investigation of Early Functional Outcomes for Oral Cancer Patients Treated with Surgical Resection and Free Flap Reconstruction
Authors: Brady Grainne , Leigh-Doyle Lauren , Riva Francesco , Kerawala Cyrus , Roe Justin
Published: September 2021

Traditionally patients can remain nil by mouth (NBM) for up to 12 days after oral tumour resection with free flap reconstruction to reduce the risk of flap dehiscence, poor healing and fistulae. The literature reports that patients could on average remain an inpatient for up to 20 days post-surgery. An evaluation of the impact of a defined early oral feeding protocol was undertaken investigating functional outcomes and complications rates. We prospectively reviewed tracheostomy use, length of hospital stay, non-oral feeding status and swallowing function using the Performance Status Scale for Head and Neck Cancer (PSS-HN) within a defined early feeding protocol. Twenty-nine patients underwent surgical resection with free flap reconstruction for advanced primary oral cancer between January 2018 and December 2019. Average age was 59.5 (range 24–88). Tumour sites included oral tongue (n = 10), maxilla (n = 6), mandible (n = 6), floor of mouth (n = 5) and buccal mucosa (n = 2). Median time to decannulation was 7 days (range 3–20 days, n = 11). The majority of patients were able to tolerate at least oral fluids on day 1 post-operatively (86%, n = 25). In addition to oral intake, non-oral feeding was required in 90% (n = 26), the majority of which included a nasogastric tube (NGT) placed intraoperatively 54% (n = 14), others required gastrostomy 46% (n = 12). Median time to nasogastric tube removal was 6 days (range 3–15 days). Median length of hospital stay was 10 days (range 3–51). Mean PSS-Normalcy of Diet (NOD) score at point of hospital discharge was 36.55 (95% CI 30.9–42.2). Flap failure was noted in 3% (n = 1). The adoption of an early oral feeding protocol suggests that there is the potential for a shorter hospital stay and earlier swallowing rehabilitation.
The gift that keeps on giving: corporate giving and excessive risk-taking
Authors: Boland Colleen M. , Ewelt-Knauer Corinna , Schneider Julia
Published: September 2021

Corporations have recently started incorporating employees’ prosocial preferences into their incentive schemes, including charitable donations (corporate giving). These donations are mainly discussed in conjunction with theexternaleffects of a firm’s CSR strategy. However, this experiment examines the effect of donations oninternalfirm operations. Specifically, we investigatewhetherthepresenceandstructureof corporate giving influences employees’ excessive risk-taking. Such prosocial activities may remediate misaligned incentives often cited as drivers for employees to take excessive risks. Contrary to widespread practice, our experimental evidence suggests that firms could constrain employees' excessive risk-taking by linking existing contributions to project rather than corporate performance, thus providing boundaries around an employee’s involvement in CSR initiatives. We identify project-level giving as an unexplored CSR benefit and infer thatpersonal responsibilityeffectively changes an employee’s incentive package. Our findings suggest an inverted U-shape curve of effectiveness.
Hop (Humulus lupulus L.): Traditional and Present Use, and Future Potential
Authors: Korpelainen Helena , Pietiläinen Maria
Published: September 2021

Hop (Humulus lupulus L.): Traditional and Present Use, and Future Potential. Hop (Humulus lupulus) is best known for its use in beer brewing owing to its bittering flavor and floral aroma. Today, the brewing industry uses as much as 98% of the produced hop crop worldwide. However, there are many other uses, some of them known since prehistoric times. Hops, the cone–like female structures called strobili, are the most frequently used part of the hop plant, but other tissues are of interest as well. The present review compiles existing knowledge of the chemical and pharmacological properties, traditional and present uses and further use potential, genetic resources, and breeding attempts in H. lupulus, and discusses climate change challenges to hop production. It contains hundreds of phytochemicals, and some of the secondary metabolites have definite potential pharmacological and medicinal value, but further investigations are desirable. Hop substances are potential alternatives, e.g., in antimicrobial, cancer, metabolic syndrome, and hormone replacement therapy treatments, as well as insecticides, preservatives, and fragrances. There are presently a few hundred cultivated hop varieties, and new cultivars are being developed and tested. Future hop breeding efforts with different quality and adaptation targets can utilize existing genetic resources, such as wild populations and landraces present in many regions.
Olivier’s theorem: ideal convergence, algebrability and Borel classification
Authors: Bartoszewicz Artur , Gła̧b Szymon , Widz Agnieszka
Published: September 2021

The classical Olivier’s theorem says that for any nonincreasing summable sequence (a(n)) the sequence (na(n)) tends to zero. This result was generalized by many authors. We propose its further generalization which implies known results. Next we consider the subset $${\mathcal {AOS}}$$
AOS
of $$ \ell _{1} $$

ℓ
1

consisting of sequences for which the assertion of Olivier’s theorem is false. We study how large and good algebraic structures are contained in $${\mathcal {AOS}}$$
AOS
and its subsets; this kind of study is known as lineability. Finally we show that $${\mathcal {AOS}}$$
AOS
is a residual $$ \mathcal {G}_{\delta \sigma } $$

G

δ
σ

but not an $$ {\mathcal {F}}_{\sigma \delta } \text {-set} $$

F

σ
δ

-set

.
Comprehensive microstructural and optical characterization of the thermal stability of aluminum-titanium oxynitride thin films after high temperature annealing in air
Authors: Escobar-Galindo R. , Heras I. , Guillén E. , Munnik F. , Azkona I. , Krause M.
Published: September 2021

The thermal stability of two AlyTi1-y(OxN1-x) layers prepared by cathodic vacuum arc deposition with different oxygen content was studied after high temperature annealing of the samples in air. These layers were designed to be part of solar-selective coating (SSC) stacks. Compositional and microstructural characterization of the thin films was performed before and after the thermal treatment by elastic recoil detection (ERD), transmission electron microscopy, and Raman spectroscopy. AlyTi1-yN sample was stable after 2 h of annealing at 450 °C. Initial stages of the formation of a surface oxide layer after annealing at 650 °C were observed both by ERD and Raman analysis. Contrarily, no changes were found after 2 h annealing treatment either at 450 and 650 °C in the composition and microstructure of AlyTi1-y(OxN1-x) sample. In both samples, the formation of a surface anatase TiO2 film was reported after 2 h annealing at 800 °C. These compositional and microstructural changes were correlated with the optical properties determined by spectroscopic ellipsometry. A transition from metallic to dielectric behavior with increasing annealing temperature was observed. These results complete the durability studies on the designed SSC based on AlyTi1-y(OxN1-x) materials, confirming that these stacks withstand breakdown at 600 °C in air.
Watching, being watched, and human interactions: evidence from trust games
Authors: Yageta Kiyotaka
Published: September 2021

Face-to-face communication increases human trust, which is crucial for making important decisions with others. Due to technological breakthroughs and the COVID-19 pandemic, human interactions now predominantly occur online, leading to two situations: other peoples’ faces cannot be seen, but yours can, and vice versa. However, the relationships among watching, being watched, and face-to-face interaction are unclear in existing papers. This paper separately measures the effects of both watching and being watched on human interactions using a trust game. I derive the optimal behaviors of senders and receivers in the trust game and empirically validate it through a controlled experiment. The results show that more than half of the participants perform the optimal behavior. They also indicate that both watching and being watched enhance human trust and reciprocity, while the synergy effect of face-to-face is not observed. Additionally, women reciprocate more when they are watched, and trust increases when participants are paired with the opposite gender and can watch their partner. This paper theoretically concludes that the former comes from women’s social pressure that they should be reciprocators, and the latter from participants’ beliefs that the opposite gender reciprocates more than the same gender does. These results propose a framework based on watching and being watched affecting human behaviors and emphasize the importance of face-to-face communication in online human interactions.
Analysis of CO2 kinetics in Na,Cs-Rho crystals using the zero length column: a case study for slow systems
Authors: Mangano Enzo , Brandani Stefano
Published: September 2021

Experimental measurements of systems with slow gas transport kinetics are generally considered a relatively easier task when compared to the challenges of measurements of very fast systems. On the other hand, when the transport process goes towards time constants of the order of several hours, not only the measurements, but also the analysis and interpretation of the data offer challenges which make the assessment of the correct time constant of the process non trivial. In this work we used the measurements of CO2 diffusion in Na,Cs-Rho crystals, carried out using the zero length column (ZLC) technique, as a case study for the use of the technique for very slow adsorption processes. The system, which has a time constant of the order of 8 h, shows the importance of using the partial loading approach for the determination of an unambiguous time constant from the analysis of the ZLC desorption curves. The traditional analysis is refined by using the nonlinear ZLC model to take into account the isotherm nonlinearity that results in a concentration dependent diffusivity. Finally, the method proposed by Cavalcante is used to confirm the 3-D diffusion path of the system.
Conjuring Hands: The Art of Curious Women of Color
Authors: wilson gloria j. , Acuff Joni Boyd , López Vanessa
Published: September 2021

The verb “to conjure” is a complex one, for it includes in its standard definition a great range of possible actions or operations, not all of them equivalent, or even compatible. In its most common usage, “to conjure” means to perform an act of magic or to invoke a supernatural force, by casting a spell, say, or performing a particular ritual or rite. But “to conjure” is also to influence, to beg, to command or constrain, to charm, to bewitch, to move or convey, to imagine, to visualize, to call to mind, or to remember. —Rachael DeLue 2012, para 1.

When we create with our Brown hands, feminine energy, and full spirits, we conjure. To exist, survive, and thrive in these bodies is a continuous act of conjuring. Our walks conjure. Our smiles conjure. Our tears conjure. Our laughs conjure. Our words conjure. Our artworks are conjurings. We, a Black/Filipina-American woman, a Dominican-American, and a Black-American woman, are guided by our solidarity with one another and all other Black and Brown female identifying persons whose raced and gendered subjectivities exist both inside and outside of colonization, white supremacy, and patriarchy. We bring to life our colored imaginations and curiosities, and share them with the world. We are united by our need for safety, autonomy as beings, dissolution of trauma, and desire to ask, “What would happen if I…?” Imaginative, curious Women of Color (WoC) founded the underground railroad, guided captured Africans and Tainos to the mountains, ignited the Civil Rights Movement, organized laborers and immigrants, birthed the #BlackLivesMatter Movement, conceived the #MeToo Movement, and so much more. Like our kindred counterparts, we have an unrelenting urge to examine, question, wonder, desire, speak to, lead, be curious, and “conjure.” As practicing artists and art educators, our critical arts-based practices are grounded in intersectional feminisms like Womanism, Black Feminist Theory, and Chicana Feminist Theory, which allow us to do these very things.
Oleic and palmitic acids induce hepatic angiopoietin-like 4 expression predominantly via PPAR-γ in Larimichthys crocea
Authors: Xiang Xiaojun , Han Shangzhe , Xu Dan , Chen Qiuchi , Ji Renlei , Zhao Zengqi , Du Jianlong , Mai Kangsen , Ai Qinghui
Published: September 2021

Angiopoietin-like 4 (ANGPTL4) is a potent regulator of TAG metabolism, but knowledge of the mechanisms underlying ANGPTL4 transcription in response to fatty acids is still limited in teleost. In the current study, we explored the molecular characterisation of ANGPTL4 and regulatory mechanisms of ANGPTL4 in response to fatty acids in large yellow croaker (Larimichthys crocea). Here, croaker angptl4 contained a 1416 bp open reading frame encoding a protein of 471 amino acids with highly conserved 12-amino acid consensus motif. Angptl4 was widely expressed in croaker, with the highest expression in the liver. In vitro, oleic and palmitic acids (OA and PA) treatments strongly increased angptl4 mRNA expression in croaker hepatocytes. Moreover, angptl4 expression was positively regulated by PPAR family (PPAR-α, β and γ), and expression of PPARγ was also significantly increased in response to OA and PA. Moreover, inhibition of PPARγ abrogated OA- or PA-induced angptl4 mRNA expression. Beyond that, PA might increase angptl4 expression partly via the insulin signalling. Overall, the expression of ANGPTL4 is strongly upregulated by OA and PA via PPARγ in the liver of croaker, which contributes to improve the understanding of the regulatory mechanisms of ANGPTL4 in fish.
Major Hospital Fire in Saint Lucia
Authors: Greenidge Charles , Cawich Shamir O. , Burt Richard , Francis Tashina
Published: September 2021

This paper provides a field report on a hospital fire at the St. Jude hospital in the Eastern Caribbean Island of Saint Lucia. The hospital was completely destroyed by the fire and three deaths were recorded. This paper analyses the emergency response to this hospital fire and discusses the lessons learned from this experience. This is a valuable lesion for developing countries in the Caribbean, especially since there have been four hospital fires reported in the Caribbean within the past decade.
Feeding practices in Australian early childhood education and care settings
Authors: Byrne Rebecca A , Baxter Kimberley , Irvine Sue , Vidgen Helen , Gallegos Danielle , Martin Elizabeth , Trost Stewart G
Published: September 2021

Objective:

Feeding practices used by educators in Early Childhood Education and Care (ECEC) settings can influence the diet quality of young children. However, Australian data is scarce and limited to describing barriers to responsive feeding. This study describes the use of feeding practices amongst a group of Australian educators.

Design:

Direct observation of feeding practices and assessment of centre policy were conducted using the ‘Environment and Policy Assessment and Observation’ tool. Self-reported feeding practices and demographic data were collected via online survey using the Childcare Food and Activity Practices Questionnaire.

Setting:

Ten centre-based ECEC services in South East Queensland, Australia.

Participants:

Educators working in ECEC.

Results:

A total of 120 meals were observed and 88 educators provided self-report data (n 84 female). Centre policy supported the use of responsive feeding practices, and this was reflected in the high frequency with which children could decide what and how much to eat, across both observed and self-report data as well as low levels of pressure to eat and use of food as a reward (observed at 19·9 % and 0 % of meals). The only apparent discrepancy was regarding modelling. Median score for self-reported role-modelling was 5·0 (4·3–5·0) and educators were observed to sit with children at 75 % of meals, however observed occasions of enthusiastic role modelling was only 22 % (0–33·3) of meals.

Conclusions:

Research addressing how educators conceptualise feeding practices, as well under what circumstances they are used, particularly in centres with different models of food provision, may shed light on why modelling is rarely implemented in practice.
‘To the benefit of Africa, the world, and ourselves’: The American Negro Leadership Conference on Africa (ANLCA) Mission to Nigeria, 1966–1968
Authors: Farquharson James Austin
Published: September 2021

Far from having only marginal significance and generating a ‘subdued’ response among African Americans, as some historians have argued, the Nigerian Civil War (1967–1970) collided at full velocity with the conflicting discourses and ideas by which Black Americans sought to understand their place in the United States and the world in the late 1960s. One of the most significant aspects of African American engagement with the civil war was the American Negro Leadership Conference on Africa peace mission that sought to bring the Federal Military Government of Nigeria and the secessionist leadership of the Republic of Biafra together through the mediation of some of the leading Black civil rights leaders in the United States. Through the use of untapped primary sources, this article will reveal that while the mission was primarily focused on finding a just solution to the internecine struggle, it also intersected with broader domestic and international crosscurrents.
«Hard Facts» bei der nicht-hormonalen Therapie des klimakterischen Syndroms
Authors: Böttcher Bettina , Wildt Ludwig
Published: September 2021

Zusammenfassung. Vasomotorische Symptome wie Hitzewallungen und Schweissausbrüche können in der Menopause einen hohen Leidensdruck bei den betroffenen Frauen auslösen. Häufig werden diese Symptome mit einer Hormontherapie behandelt; jedoch möchten oder dürfen nicht alle Frauen eine Hormontherapie verwenden. Für diese Frauen gibt es nicht-hormonelle Alternativen. Diese umfassen pharmakologische Substanzen wie Antidepressiva, Antikonvulsiva oder Antihypertensiva, Phytopharmaka sowie weitere komplementärmedizinische Ansätze wie Yoga, Sport, Hypnose, kognitive Verhaltenstherapie und Akupunktur. Zusammenfassend lässt sich feststellen, dass die Datenlage für die pharmakologischen Substanzen ausreichend ist und insbesondere Paroxetin, Venlafaxin, Gabapentin und Clonidin gute Effekte auf die Reduktion vasomotorischer Symptome bei menopausalen Frauen zeigen. Für Phytopharmaka ist die Datenlage schlechter, vor allem, wenn das Studiendesign guten wissenschaftlichen Kriterien entsprechen soll. Die besten Daten gibt es für Isoflavone und Extrakte aus der Traubensilberkerze, die signifikant Hitzewallungen im Vergleich zu Placebo reduzieren. Die komplementärmedizinischen Ansätze, insbesondere Akupunktur, zeigen teils vielversprechende Ergebnisse.
Die Rolle von arbeitsplatzbezogener Flexibilisierung und die Betrachtung von individuellen Werten für Mitarbeitendenbindung in der Arbeitswelt 4.0
Authors: Bender Elena , Schürmann Mirko , Poethke Ute , Soyka Chantal , Schaper Niclas , Rowold und Jens
Published: September 2021

Zusammenfassung. In der Arbeit 4.0 ist durch neue Beschäftigungsmöglichkeiten für Mitarbeitende eine Langzeitbindung an ein Unternehmen seltener. Unternehmen reagieren mit flexibilisierten Arbeitsplätzen, um diesem Wunsch der Mitarbeitenden nachzukommen. Flexibilisierung reduziert die Absicht das Unternehmen zu verlassen. Dabei ist wichtig, räumliche und zeitliche Flexibilisierung zu differenzieren. Außerdem gewinnen individuelle Werte bezüglich Stabilität und Kontinuität an Bedeutung und können den Bindungswunsch stärken. Hauptziel dieser Untersuchung ist, anhand eines kontroll- und ressourcentheoretisch fundierten Rahmens in zwei aufeinander aufbauenden Studien ( N = 448, N = 202) die (potenziell unterschiedlich starken) Zusammenhänge von zeitlicher und räumlicher Flexibilisierung mit Mitarbeitendenbindung zu analysieren und zu prüfen, ob sich diese Zusammenhänge bestätigen lassen, wenn zusätzlich individuelle Werte in die Analyse einbezogen werden. Die Ergebnisse zeigen, dass zeitliche und räumliche Flexibilisierung unterschiedlich mit der Bleibeabsicht zusammenhängen. Während zeitliche Flexibilisierung positive Zusammenhänge zeigt, finden sich in Bezug auf räumliche Flexibilisierung keine Zusammenhänge. Werte bezüglich Stabilität und Kontinuität scheinen dabei nicht mit einer stärkeren Mitarbeitendenbindung zusammenzuhängen.
Suddenly Working From Home!
Authors: Dettmers Jan , Plückhahn Wiebke
Published: September 2021

Abstract. The Corona crisis and the lockdown in the spring of 2020 had various effects on working life in Europe. In this three-wave study, we assessed the trajectories of job demands and resources of 302 employees 2 weeks before the lockdown, over 1 week after lockdown start, and 6 weeks following the beginning of the lockdown. We applied a pre-post follow-up design with 129 employees who switched to telecommuting and a control group of 173 employees who remained in their on-site workplace. Results from the repeated-measures MANCOVA indicate that, despite various general changes to job characteristics because of the Corona crisis, telecommuting changes contributed to significant changes only in communication opportunities and – before Bonferroni correction – in physical job demands. These results may imply that the most visible massive switch to telecommuting of many employees during the first phase of the Corona crisis is only one explanatory factor for general changes to job characteristics.
Advancing the Evidence Base of Future Warming Impacts on Human Mobility in African Drylands
Authors: Thalheimer Lisa , Williams David S. , van der Geest Kees , Otto Friederike E. L.
Published: September 2021

A better understanding of climate change impacts and resulting human responses (climate‐related human mobility) have been identified as a research priority by the climate science community. Here, we provide the basis for future research efforts by identifying knowledge gaps and consolidating published evidence in the IPCC 1.5 Special Report (SR15) with recent evidence from climate science and the literature on human mobility in African drylands, a region where migrants are particularly vulnerable to climate change. We first synthesize climatic changes and their projected impacts across the region to then contextualize the projected impacts with current knowledge regarding the effect of anthropogenic climate change on human mobility. We discuss these often indirect impact channels and argue that a systems approach is needed to address the interconnectedness of climate impacts and the cascading risks of adverse consequences for human mobility.
Reviewing Reviewers
Authors: Wooden Paige
Published: September 2021

AGU analyzes reviewer age, gender, and geographic location especially to see how the pandemic may have affected our reviewer pool.
Climatology Analysis of the Daytime Topside Ionospheric Diffusive O+ Flux Based on Incoherent Scatter Radar Observations at Millstone Hill
Authors: Cai Yihui , Wang Wenbin , Zhang Shun‐Rong , Yue Xinan , Ren Zhipeng , Liu Huixin
Published: September 2021

This paper reports the characteristics of the topside ionospheric O+ diffusive flux () during both geomagnetically quiet (0 ≤ Kp ≤ 2) and moderate (2 < Kp ≤ 4) times using incoherent scatter radar observations at Millstone Hill (42.6°N, 288.5°E) for solar minimum from 1970 to 2018. partially characterizes plasma mass exchange between the upper and lower part of the topside ionosphere through diffusion and sometimes serves as upper boundary conditions for ionosphere‐thermosphere models. The altitude where the flux sign changes (mainly during daytime) is termed the transition height and the time when the flux sign changes (mainly at dawn and dusk) is termed the transition time. At quiet times, the daytime transition height is ∼100 km above the peak height (hmF2) in summer, and it is about 50 km above hmF2 in other seasons; the transition time is before 18 solar local time (SLT) in spring and winter, but after 18 SLT in summer and autumn. The daytime average upward above the transition height shows a significant seasonal variation with a minimum of in summer and a maximum of in autumn. Under geomagnetically moderate conditions, the transition height increases by ∼20 km in spring, winter, and autumn, but moves up by about 20–50 km in summer. The transition time occurs later by ∼1 hr in summer but ∼1 hr earlier in other seasons. The mean upward peaks in summer and minimizes in spring.
Effect of Interplanetary Magnetic Field on Hemispheric Asymmetry in Ionospheric Horizontal and Field‐Aligned Currents During Different Seasons
Authors: Workayehu A. B. , Vanhamäki H. , Aikio A. T. , Shepherd S. G.
Published: September 2021

We present a statistical investigation of the effects of interplanetary magnetic field (IMF) on hemispheric asymmetry in auroral currents. Nearly 6 years of magnetic field measurements from Swarm A and C satellites are analyzed. Bootstrap resampling is used to remove the difference in the number of samples and IMF conditions between the local seasons and the hemispheres. Currents are stronger in Northern Hemisphere (NH) than Southern Hemisphere (SH) for IMF B in NH (B in SH) in most local seasons under both signs of IMF B. For B in NH (B in SH), the hemispheric difference in currents is small except in local winter when currents in NH are stronger than in SH. During B and B in NH (B and B in SH), the largest hemispheric asymmetry occurs in local winter and autumn, when the NH/SH ratio of field aligned current (FAC) is 1.18 0.09 in winter and 1.17 0.09 in autumn. During B and B in NH (B and B in SH), the largest asymmetry is observed in local autumn with NH/SH ratio of 1.16 0.07 for FAC. We also find an explicit B effect on auroral currents in a given hemisphere: on average B in NH and B in SH causes larger currents than vice versa. The explicit B effect on divergence‐free current during IMF B is in very good agreement with the B effect on the cross polar cap potential from the Super Dual Auroral Radar Network dynamic model except at SH equinox and NH summer.
Variability of the Interplanetary Magnetic Field as a Driver of Electromagnetic Induction in Mercury's Interior
Authors: Zomerdijk‐Russell S. , Masters A. , Heyner D.
Published: September 2021

Mercury's magnetosphere is a unique and dynamic system, primarily due to the proximity of the planet to the Sun and its small size. Interactions between solar wind and embedded interplanetary magnetic field (IMF) and the dayside Hermean magnetosphere drive an electric current on the system's magnetopause boundary. So far, electromagnetic induction due to magnetopause motion in response to changing external pressure has been used to constrain Mercury's iron core size. Here we assess the impact a changing IMF direction has on the Hermean magnetopause currents, and the resulting inducing magnetic field. Observations made by the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft during dayside magnetopause boundary crossings in the first “hot season,” are used to demonstrate the importance of the IMF direction to Mercury's magnetopause currents. Our 16 boundary crossings show that introduction of external IMFs change the magnetopause current direction by 10° to 100°, compared to the case where only the internal planetary field is considered. Analytical modeling was used to fill in the bigger picture and suggests for an east‐west reversal of the IMF, typical of the heliospheric current sheet sweeping over Mercury's magnetosphere, the inducing field at Mercury's surface caused by the resulting magnetopause current dynamics is on the order of 30% of the global planetary field. These results suggest that IMF variability alone has an appreciable effect on Mercury's magnetopause current and generates a significant inducing magnetic field around the planet. The arrival of the BepiColombo mission will allow this response to be further explored as a method of probing Mercury's interior.
Cataloging Tectonic Tremor Energy Radiation in the Cascadia Subduction Zone
Authors: Wech Aaron G.
Published: September 2021

For the past ∼12 years the Pacific Northwest Seismic Network has been automatically detecting and locating tectonic tremor across the Cascadia subduction zone, resulting in a catalog of more than 500,000 tremor epicenters to date, which has served as a valuable resource for tremor and slip research. This manuscript presents an updated methodology for routine tremor detection in Cascadia and a new catalog of over 180,000 tremor epicenters including amplitudes detected along the subduction zone margin from 2017 to 2021. The events are detected via cross‐correlation of continuous vertical envelope data of 128 stations from northern California to northern Vancouver Island. The modified approach results in less scatter and a 55% increase in detected epicenters than previously observed, as well as a newly identified tremor source offset updip from the main tremor and slip region at the southern edge of the subduction zone. Radiated seismic energy in the 1.5–5 Hz band is used to assign epicenters an energy magnitude (MeL), which is calibrated to the ML of local earthquakes. Southern Cascadia is most active, but the highest tremor energy rates occur in northern Cascadia. Tremor in central Cascadia is systematically weaker and less frequent. Individual epicenter magnitudes range from ∼0.5–2 and spatiotemporally cluster into 1,060 swarms with cumulative MeL ranging from ∼0.8 to 3.7. The swarms reflect underlying slow slip events and occur with an earthquake‐like energy distribution with a b value ∼1. Tremor epicenters, however, follow a tapered Gutenberg‐Richter distribution with high b values, suggesting individual tremor bursts and their constituent low‐frequency earthquakes are fault‐dimension limited.
Are the Different Eddy Metrics Quantifying the Winter North Pacific Storm Track Consistent With Each Other?
Authors: Yang Minghao , Li Xin , Li Chongyin , Chen Xiong , Zhang Chao , Chen Guiwan , Li Lifeng
Published: September 2021

Historical simulations from twenty‐nine Coupled Model Intercomparison Project Phase 6 (CMIP6) models are used to investigate the consistency among different eddy metrics characterizing the winter North Pacific storm track (WNPST). All CMIP6 models can reproduce the basic climatological characteristics of the WNPST. Results show that, out of the metrics studies, only the upper‐tropospheric filtered meridional wind variance () is significantly correlated with the model grid spacing. The climatological amplitudes of different eddy metrics are consistent with each other, except for the consistency between the upper‐tropospheric and lower‐tropospheric meridional eddy heat flux and that between the middle‐tropospheric eddy kinetic energy and filtered sea level pressure variance (). The strength trends of different eddy metrics are consistent with each other except for upper‐tropospheric and . The meridional migration trends are consistent among different eddy metrics excluding . Given that the sensitivity to horizontal resolution, climatological amplitude, strength trend and meridional migration trend of different Eulerian eddy metrics may exhibit inconsistency, the use of multiple eddy metrics to increase the reliability of the results is suggested.
Climatic Drivers of Deglacial SST Variability in the Eastern Pacific
Authors: Meegan Kumar Dervla , Tierney Jessica E. , Bhattacharya Tripti , Zhu Jiang , McCarty Logan , Murray James W.
Published: September 2021

We explore the response of northeastern Pacific sea surface temperature (SST) to deglacial (16–7 ka) climate variability as recorded in ‐based SST reconstructions spanning 65°N to 10°S. Included in the analysis is a new 23 kyr SST record from core NH8P from the northwest Mexican Margin. We isolate spatiotemporal patterns in regional SSTs with trend empirical orthogonal function (TEOF) analysis. The dominant TEOF mode reflects deglacial warming associated with rising . Tropical and subtropical SSTs correlated most strongly with this mode, suggesting that the thermodynamic response of the tropical eastern Pacific to greenhouse gas forcing was the dominant driver of regional SST change during deglaciation. The second TEOF mode reflects millennial‐scale variability and is most strongly expressed in subpolar SSTs. The synchronous timing between North Pacific and North Atlantic SST oscillations is evidence for the rapid transmission of millennial‐scale climate perturbations between the basins, likely through an atmospheric teleconnection. SSTs at NH8P have no correlation with either leading TEOF mode as there is minimal change in SST at this site after 20 ka. A model simulation of the LGM indicates that glacial cooling was muted in much of the Eastern Pacific Warm Pool (EPWP), in which NH8P lies, due to reductions in latent heat flux. This suggests that the wind‐evaporation‐SST feedback was responsible for the attenuation of EPWP cooling. Overall, this study highlights the distinct latitudinal trends in the Pacific's response to deglaciation.
The Effect of Roughness Spacing and Size on the Lateral Deflection of Bedload Particles
Authors: He Chuanqi , Yang Ci‐Jian , Turowski Jens M.
Published: September 2021

Bedrock river lateral erosion plays a crucial role in landscape evolution, sediment transport and deposition, and the occurrence of geohazards. Fluvial erosion of massive rock is largely driven by impacts of bedload particles, which also drives crack propagation to prepare blocks for plucking. In straight channels, bedload particles generally move parallel to the channel walls and thus need to be deflected laterally to cause wall erosion. Sideward deflection of bedload particles occurs when they interact with roughness elements fixed on the riverbed. Here, we isolated the interaction of moving bedload particles with roughness elements in laboratory experiments. We conducted 21 sets of flume experiments to systematically investigate how spacing (5, 10, 20, 30, 40, 50, and 60 mm) and size (5, 10, and 20 mm) of roughness elements influence sideward deflection of bedload particles in straight channels with relatively low flow depth and a localized roughness zone covering half of the channel width. Velocity changes by the first impact increase with the size of roughness elements. The deflection length and velocity peak at intermediate values of the spacing of roughness elements. The likelihood for a bedload particle to leave the roughness zone decays with the bedload particle's distance to its edge. Our results suggest that lateral erosion rates in bedrock channels are dominantly controlled by the position of the roughness zone within the channel and its relation to the particle path.
Perfecting and extending the near-infrared imaging window
Authors: Feng Zhe , Tang Tao , Wu Tianxiang , Yu Xiaoming , Zhang Yuhuang , Wang Meng , Zheng Junyan , Ying Yanyun , Chen Siyi , Zhou Jing , Fan Xiaoxiao , Zhang Dan , Li Shengliang , Zhang Mingxi , Qian Jun
Published: September 2021

In vivo fluorescence imaging in the second near-infrared window (NIR-II) has been considered as a promising technique for visualizing mammals. However, the definition of the NIR-II region and the mechanism accounting for the excellent performance still need to be perfected. Herein, we simulate the photon propagation in the NIR region (to 2340 nm), confirm the positive contribution of moderate light absorption by water in intravital imaging and perfect the NIR-II window as 900–1880 nm, where 1400–1500 and 1700–1880 nm are defined as NIR-IIx and NIR-IIc regions, respectively. Moreover, 2080–2340 nm is newly proposed as the third near-infrared (NIR-III) window, which is believed to provide the best imaging quality. The wide-field fluorescence microscopy in the brain is performed around the NIR-IIx region, with excellent optical sectioning strength and the largest imaging depth of intravital NIR-II fluorescence microscopy to date. We also propose 1400 nm long-pass detection in off-peak NIR-II imaging whose performance exceeds that of NIR-IIb imaging, using bright fluorophores with short emission wavelength.
Characterization of Functional Hybrid Nanomaterials
Authors: Salimi E. , Abidin M. N. Z.
Published: September 2021

Arrangement, spatial configuration and chemical interactions of organic and inorganic elements in hybrid structures have led to the generation of various materials that range in size from nanometers to macrometers. In order to analyze the physical, chemical and also mechanical properties of these newly emerged compounds, a combination of different analytical techniques is necessary. This chapter provides a broad overview on the characterization strategies used to study the features of functional hybrid nanomaterials.
Antimicrobial Nanocomposites for Environmental Remediation
Authors: Nagappan Saravanan , Peter Jerome , Thomas Anju Maria , Mohan Anandhu , Hira Shamim Ahmed , Park Kang Hyun , Ha Chang-Sik
Published: September 2021

In recent times, antimicrobial nanocomposites have attracted significant attention in various applications and products due to the safety and hygiene concerns of the modern life style as well as during the recent pandemic (COVID-19) situation. Antimicrobial nanocomposites are prepared generally by mixing antibacterial organic compounds with various metal ions or metal nanoparticles, such as silver, gold, zinc, copper, aluminium, etc., with a polymer and other nanomaterials as support. The use of high-cost metal nanoparticles limits practical applications. Hence, significant attention has been focussed on the development of low-cost antimicrobial nanocomposites for multiple applications. In this chapter, we briefly focus on various pathways of developing antimicrobial nanocomposites for a wide variety of applications and highlight the importance of antimicrobial nanocomposites and the future demand for environmentally friendly nanocomposites.
Blood rheometer based on microflow manipulation of continuous blood flows using push-and-back mechanism
Authors: Kang Yang Jun
Published: September 2021

A push-and-back mechanism was suggested for simultaneously measuring rheological properties of blood in microfluidic platform.