bluuebunny/crossref_metadata_2025 huggingface dataset:
EVALUASI PENERAPAN SISTEM INFORMASI MANAJEMEN RUMAH SAKIT DENGAN MENGGUNAKAN METODE TAM
Authors: Pratiwi Nindhiya Dwi
Published: March 2022

Pengembangan sistem informasi kesehatan dilakukan melalui kegiatan perencanaan sistem, analisis sistem, perancangan sistem, pengembangan perangkat lunak, penyediaan perangkat keras, uji coba sistem, implementasi sistem, serta pemeliharaan dan evaluasi sistem (Peraturan Pemerintah, 2014). Namun beberapa penelitian menunjukkan adanya permasalahan pada penerapan sistem informasi yang terdapat di rumah sakit. 38 % penerapan SIMRS yang tidak sesuai berdampak pada keputusan yang diambil oleh pihak rumah sakit menjadi tidak tepat. Tujuan dari penelitian ini adalah mengevaluasi hubungan antar variabel TAM (Technology Acceptance Model) serta perbedaan dan persamaan hasil penelitian evaluasi penerapan SIMRS pada 13 artikel. Metode yang digunakan adalah literature review. Dari hasil pencarian ditemukan 13 artikel yang sesuai dengan kriteria inklusi dan kriteria eklusi. 75 % hasil penelitian menunjukkan pengaruh yang positif antara perceived usefulness terhadap attitude toward using. 70 % hasil penelitian menunjukkan adanya pengaruh yang positif dan signifikan antara perceived usefulness terhadap behavioral intention to use. 78 % menunjukkan adanya pengaruh yang terjadi antara attitude toward using terhadap behavioral intention to use. 87 % dari hasil penelitian menunjukkan hubungan antara behavioral intention to use terhadap actual system use. Hasil review menunjukkan 4 persamaan dan 5 perbedaan hasil penelitian evaluasi penerapan SIMRS dari penelitian terdahulu. Upaya yang dapat dilakukan untuk mengatasi hal tersebut diantaranya meningkatkan keterampilan pengguna dalam menggunakan teknologi, perlu adanya Standar Operasional Prosedur (SOP) mengenai pengoperasian sistem informasi, melakukan evaluasi SIMRS secara berkala, memberikan contoh kepada para staff agar menumbuhkan minat, menyiapkan tim IT yang handal.
RANCANG BANGUN SISTEM INFORMASI APOTEK DALAM MENINGKATKAN PELAYANAN DI KLINIK PRATAMA ROLAS MEDIKA JEMBER
Authors: Loren Errica Rostia , Farlinda Sustin , Wibowo Nugroho Setyo , Hendyca Putra Dony Setiawan
Published: March 2022

Pelayanan kesehatan di Klinik Pratama Rolas Medika Jember sudah menggunakan sistem komputerisasi. Salah satu sistem komputerisasi yaitu adanya sistem informasi apotek yang telah digunakan di Apotek Rolas Medika milik klinik tersebut. Penggunaan sistem informasi apotek tersebut masih terdapat kendala dan kekurangan seperti tidak adanya form retur obat, mutasi obat dan tidak adanya pemberitahuan warning expired date pada sistem tersebut, sehingga petugas harus mengerjakannya secara manual. Tujuan penelitian ini adalah mengembangkan sistem informasi apotek dengan merancang dan membuat sistem informasi apotek sesuai kebutuhan pengguna dalam meningkatkan pelayanan di Klinik Pratama Rolas Medika Jember. Jenis penelitian ini adalah kualitatif dengan menggunakan metode pengembangan prototipe. Pengambilan data dilakukan dengan wawancara, observasi, dan dokumentasi. Hasil dari penelitian ini adalah sistem informasi apotek di Klinik Pratama Rolas Medika Jember yang dapat meningkatkan pelayanan dan dengan adanya pemberitahuan warning expired date dapat mempermudah petugas dalam mengetahui jumlah stok obat yang akan mendekati tanggal kadaluarsa.
CARACTERÍSTICAS EPIDEMIOLÓGICAS DA MORTALIDADE NEONATAL E INFANTIL EM UMA REGIONAL DE SAÚDE
Authors: Costa Lediana Dalla , Borges Lucimara de Macedo
Published: March 2022

Objetivou-se analisar o perfil epidemiológico e as causas da mortalidade neonatal e infantil, em uma Regional de Saúde, de janeiro/2018 a agosto/2020. Trata-se de pesquisa exploratória, descritiva, transversal, retrospectivo, com abordagem quantitativa. A coleta de dados ocorreu em agosto de 2020, por meio de questionário elaborado pelas pesquisadoras, com base nas declarações de óbito disponibilizados no Sistema de Informações de Mortalidade. O instrumento abordou as variáveis sexo, raça, cor, idade da criança, idade materna, escolaridade materna, via de parto, idade gestacional, peso ao nascer, causa do óbito. Os dados foram submetidos à análise estatística descritiva e distribuição de frequência, por meio do Statistical Package for the Social Sciences (SPSS), versão 25.0. Constatou-se o predomínio de óbitos no sexo masculino (56,5%), de raça branca (87,8%), com equivalência entre extremo baixo peso e adequado (31,3%), com a principal causa de óbito por septicemia (13,9%). Quanto aos dados maternos, prevaleceram idade entre 21 e 30 anos de idade (45,2%) com gestação única (85,21%) e parto cesariano (65,2 %). Destes, 47,87% ocorreram no ano de 2018. Analisar os aspectos da mortalidade neonatal e infantil possibilita o planejamento e a readequação de ações no atendimento à saúde da criança, durante o período mais vulnerável e mais crítico dela, contribuindo, assim, para redução do número de óbitos.
QUALIDADE LOGÍSTICA E SEUS EFEITOS NAS EXPORTAÇÕES MUNDIAIS DE BENS AGRÍCOLAS
Authors: Rodrigues Corrêa Ferreira Carolina , Cesar Pinto Fagundes Lauro , Gonçalves de Souza Bruna
Published: March 2022

A qualidade da rede logística é um importante aspecto das relações comerciais entre países, principalmente no caso dos bens agrícolas, pois a rapidez e cuidado na entrega são de extrema importância por sua maior perecibilidade. Assim, esse trabalho tem por objetivo avaliar o impacto da eficiência logística nas exportações de bens agrícolas, no período entre 2007 e 2018, para um grupo de 168 países. Para tanto, propõe a realização de uma análise descritiva de um indicador de eficiência logística e a estimação de uma regressão baseada no modelo gravitacional. A análise descritiva mostrou que os países com pior desempenho são aqueles mais pobres e os do continente africano, enquanto os de melhores resultados são aqueles de alta renda. A regressão estimada revelou que uma maior qualidade logística afeta positivamente as exportações agrícolas. Desta forma, é necessário discutir quais políticas e ações devem ser feitas com o objetivo de aprimorar a rede de logística nos países, estimulando projetos que visem melhorar a infraestrutura, a rastreabilidade e tornar mais eficientes os procedimentos aduaneiros.
A correlação entre a tuberculose e o desenvolvimento de lesão renal: uma revisão integrativa
Authors: Rotilli Katherine Wilt , Valenzuela Rolando Guilhermo Vermehren
Published: March 2022

Objetivo: Verificar as evidências científicas sobre as características da lesão renal causada por tuberculose. Métodos: Revisão integrativa da literatura, com busca nas bases de dados SCIELO, PUBMED, LILACS e MEDLINE dos artigos publicados nos últimos cinco anos. Os dados foram analisados através de pré-análise, exploração do material, tratamento dos dados e interpretação dos dados, sendo expostos em quadro. Resultados: Foram encontrados onze artigos correspondente com nosso objetivo. O tecido renal é o local preferido para a colonização por Mycobacterium tuberculosis, sendo a região medular a que apresenta maior lesão, exibindo necrose caseosa, com consequente lesão tecidual local e destruição pernamente. A lesão inicia-se no córtex renal, com posterior migração dos bacilos até a junção córtico-medular, construindo granulomas corticais que permanecem estáveis por muitos anos. Considerações finais: Foi possível observar que a maioria de casos evolui tipicamente, porém, há casos que demonstraram a forma pseudotumoral de tuberculose renal. Com base nestes dados faz-se necessária a continuidade de pesquisas relacionas a este tema.
Development optimal conditions for cryopreservation of tissue-engineered corneal constructs
Authors:   Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation, Borzenok S.A. ,   Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russian Federation, Kostenev S.V. ,   Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation, Doga A.V. ,   Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation, Li V.G. ,   Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation, Ostrovskiy D.S. ,   Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation, Khubetsova M.K. ,   Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation
Published: March 2022

Relevance. In recent years, due to the shortage of donor corneas, the need to creating conditions for storing stromal lenticules in eye banks for their clinical use in ophthalmosurgery have been actively discussed. Currently, scientists are looking for optimal conditions for storage native lenticules. There were no reports of storage of decellularized lenticules in the literature. Purpose. To develop optimal conditions for cryopreservation of stromal tissue-engineered constructs for the subsequent creation of a cryobank. Material and methods. The optical properties of native lenticules and tissue–engineered corneal constructs (TCs) were assessed using spectrophotometry. We used a decellularization protocol with 1.5 M NaCl with DNase 5 U/ml and RNase 5 U/ml to create TC. Dispersed viscoelastic agent approved for clinical use in ophthalmology was used for dehydration of TC. Three comparison groups were formed: 1st – control group (native lenticules), 2nd – group without dehydration of TC, 3rd – group with dehydration of TC. The spectrophotometer data was evaluated in 2 stages. The transparency of the control group was measured at 1 stage. At the second stage, the transparency of two experimental groups after storage in DMSO was investigated (a group without dehydration of TC and a group with dehydration of TC). Results. When compared between groups without dehydration of TC; with dehydration of TC and the control group (p≥0.05), no statistical difference was revealed, and when comparing groups without dehydration of TC and groups with dehydration of TC (p≥0.05), no statistical difference was revealed. Conclusion. Groups with dehydration of TC and without dehydration of TC after storage in DMSO did not differ in transparency. In this regard, these groups should be considered as interchangeable in terms of optical properties. Key words: storage, cryopreservation, lenticule, cornea, decellularization, tissue engineering
Application of artificial intelligence in diagnostics and surgery of keratoconus: a systematic overview
Authors:   Fyodorov Eye Microsurgery Complex Federal State Institution, Moscow, Russian Federation, Malyugin B.E. ,   Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russian Federation, Sakhnov S.N. ,   Fyodorov Eye Microsurgery Complex Federal State Institution, Krasnodar branch, Russian Federation,   Kuban State Medical University, Krasnodar, Russian Federation, Axenova L.E. ,   Fyodorov Eye Microsurgery Complex Federal State Institution, Krasnodar branch, Russian Federation, Myasnikova V.V. ,   Fyodorov Eye Microsurgery Complex Federal State Institution, Krasnodar branch, Russian Federation,   Kuban State Medical University, Krasnodar, Russian Federation
Published: March 2022

Introduction. Artificial Intelligence is new theoretical approaches, methods, technologies and applied systems for modeling and extending human intelligence. In ophthalmology, artificial intelligence is one of the tools that help improve the efficiency of the treatment process through more accurate diagnostics, search for new biomarkers of diseases, automation of decision-making processes and assistance in other aspects of the physician‘s daily activities. The purpose of this review is to describe the currently available developments for the diagnosis and surgery of keratoconus in the field of artificial intelligence. Material and methods. Databases that were used for literature search included: Google and Google Scholar, PubMed, Embase, MEDLINE and Web of Science. Results. As a result of a search across all selected databases, as well as a selection of relevant studies, 75 articles were analyzed. Most of the studies that were selected for full-text analysis were the development of diagnostic algorithms. The most common classical machine learning methods were support vector machines method and random forest method. The most commonly used type of neural network is the convolutional neural network. 4 studies out of 75 reported the creation of a graphical interface for using the developed algorithm in a clinical environment. Conclusion. The accuracy of the algorithms that were obtained in the analyzed researches was basically more than 90%. It indicates the ability of machine learning models to solve complex clinical problems. Key words: artificial intelligence, machine learning, keratoconus, diagnostics
Synthetic Attempts towards Polymers with Pentafulvene Structural Units
Authors: Zhang Gengyi , Neuenschwander Markus
Published: March 2022

Pentafulvenes with weakly electron-donating substituents at C(6) (X = SMe) may be submitted to cationic polymerization which had been reported before only for 6-alkyl-, 6-aryl-, and 6,6-dialkylpentafulvenes. This procedure does not work for pentafulvenes like 1c with strong electron-releasing substituents at C(6) (X = Me2N). Based on bromination-elimination experiments with model compound 6, it has been shown that direct bromination of polyfulvene 2a → 10a is very efficient. This result is important in view of the synthesis of polymers 3a with pentafulvene structural elements. So far, only partial HBr elimination of polymer 10a has been achieved, while I2 treatment of 10a gives a insoluble charcoal-like black polymer absorbing in the whole UV/VIS range.
Highly Efficient Lipase-Catalyzed Kinetic Resolution of Chiral Amines
Authors: Reetz Manfred T. , Dreisbach Claus
Published: March 2022

The lipase Candida antarctica catalyzes the enantioselective acetylation of chiral primary amines, kinetic resolution leading to an enantiomeric excess (ee) of 90–98%.
The Industrial Electrolytic Regeneration of Mn2(SO4)3 for the Oxidation of Substituted Toluene to the Corresponding Benzaldehyde
Authors: Vaudano Pierre , Plattner Eric , Comninellis Christos
Published: March 2022

A new industrial process for the electrolytic regeneration of Mn2(SO4)3 is presented in which:– a slurry of MnSO4/Mn2(SO4)3 in 55% H2SO4 is used as a carrier,– the
electrolyte is purified with an optimum mode before electrogeneration, and–a new industrial electrochemical reactor is developed for an economical electrogeneration of Mn2(SO4)3
Electrochemical Treatment of Industrial Organic Effluents
Authors: Savall André
Published: March 2022

The anodic oxidation of organics is a potentially powerful technique of controlling pollutants in industrial waste waters. Based on a fundamental analysis, this paper summarizes recent results in this field. Direct electrochemical processes catalyzed by the oxygen-transfer reaction are discussed for several anode materials. Ti/SnO2 is particularly efficient for cold combustion of aromatic pollutants. Potential candidate processes involving the electrochemical generation of oxidizer reactants (O3, H2O2), or the electrochemical regeneration of metallic redox couples are discussed.
Notiz zur Umlagerung von 5-Chloro-5-(dialkylamino)-pentadienalen
Authors: Berger Daniel , Neuenschwander Markus
Published: March 2022

Similarly to 3-chloro-3-(dimethylamino)acrolein (2), 5-chloro-5-(dimethylamino)penta-2,4-dienal (6) easily rearranges in the presence of traces of acid to 2-(dimethylamino)pyrilium chloride (8), which is the postulated intermediate of the rearrangement of 6 to 5-chloropenta-2,4-dien-N,N-dimethylamide (10).
ESTIMATION OF BEARING ABILITY WHEN THE POST-BUCKLING BEHAVIOR OF COMPOSITE PANELS WITH NONSYMMETRIC STRUCTURE UNDER SHEAR TAKING INTO ACCOUNT THE INITIAL DEFLECTION FROM COMPRESSION
Authors: Митрофанов О.В.
Published: March 2022

На основе аналитического решения геометрически нелинейной задачи о закритическом поведении короткой прямоугольной композитной панели несимметричной структуры при сдвиге с учетом начальной погиби, которая получена от сжатия, представлена методика оценки несущей способности при геометрически нелинейном поведении.

On the basis of the analytical solution of geometrically nonlinear problem on the postbuckling behavior of a short rectangular composite panel of asymmetric structure with shear taking into account the initial defl ection which is obtained from compression, the method of estimating the bearing capacity for geometrically nonlinear behavior is presented.
Electronic Communication and Photoinduced Intramolecular Electron Transfer in Hybrid Ru(II)-Re(I) Complexes Using Eigenstate-Based and Diabatic-State-Based Models
Authors: Ketkaew Rangsiman
Published: March 2022

Photoinduced intramolecular electron transfer (PIET) plays a vital role in the efficiency of electronics communication in transition metal complexes catalysing oxidation-reduction reaction. In this work, we theoretically calculate the rate of electron transfer(ET) in Ru(II)-BL-Ru(I) hybrid complexes; where BL is bridging ligand. A brief concept of ET in the basis of Marcus theory, which is extended to address a variety of different type of ET, is provided. We show that, in the case of Ru(II)-BL-Ru(I) complex, ET involves a non-adiabatic state which thanks to a fast electronics communication between donor and acceptor connected by BL and becomes rigid complex. Single electron transferring in Ru(II)-BL-Ru(I) complex governed by PIET constructed by potential energy curve as change of structural transformation over time-evolution. We also investigate the mechanism of PIET involving a redox reaction in excited state, wherein the oxidation state of Ru(II) (donor) and Ru(I) (acceptor) changes. To access non-adiabatic state of Ru(II)-BL-Ru(I), we use constrained density functional theory to allow ground state calculation to be performed along with geometry constraints. We also systematically study the role of distance of donor-acceptor separation on kinetics of PIET
On the experimental determination of 4f-4f intensity parameters from the emission spectra of europium (III) compounds
Authors: Blois Lucca , Carneiro Neto Albano , Longo Ricardo , Costa Israel , Paolini Tiago , Brito Hermi , Malta Oscar
Published: March 2022

Eu3+ complexes and specially β-diketonate compounds are well known and studied in several areas due to their luminescence properties, such as sensors and lightning devices. A unique feature of the Eu3+ ion is the experimental determination of the 4f-4f intensity parameters Ωλ directly from the emission spectrum. The equations for determining Ωλ from the emission spectra are different for the detection of emitted power compared to modern equipment that detects photons per second. It is shown that the differences between Ωλ determined by misusing the equations are sizable for Ω4 (ca. 15.5%) for several Eu3+β-diketonate complexes and leads to differences of ca. 5% in the intrinsic quantum yields Q_Ln^Ln. Due to the unique features of trivalent lanthanide ions, such as the shielding of 4f-electrons, which lead to small covalency and crystal field effects, a linear correlation was observed between Ωλ obtained using the emitted power and photon counting equations. We stress that care should be exercised with the type of detection should be taken and provide the correction factors for the intensity parameters. In addition, we suggest that the integrated intensity (proportional to the areas of the emission band) and the centroid (or barycenter) of the transition for obtaining Ωλ should be determined in the properly Jacobian-transformed spectrum in wavenumbers (or energy). Due to the small widths of the emission bands of typical 4f-4f transitions, the areas and centroids of the bands do not depend on the transformation within the experimental uncertainties. These assessments are relevant because they validate previously determined Ωλ without the proper spectral transformation.
TO THE QUESTION OF THE PROTECTION OF CIVIL RIGHTS UNDER CONDITIONS OF ONE-SIDED RESTRICTIVE MEASURES OF FOREIGN STATES
Authors: Чернядьева Наталья Алексеевна
Published: March 2022

Односторонние ограничительные меры, применяемые к Российской Федерации, противоречат нормам международного права, являются политически мотивированными и нарушают суверенные права нашего государства. В статье автор рассматривает проблему экстерриториального характера применения национального права и пытается обратить на нее внимание как научного сообщества, так и законодателя.

Unilateral restrictive measures applied to the Russian Federation are contrary to the norms of international law, are politically motivated and violate the sovereign rights of our state. In the article, the author examines the problem of the extraterritorial nature of the application of national law and tries to draw the attention of both the scientific community and the legislator to it.
NANOTECHNOLOGY: THE NEW INDUSTRIAL REVOLUTION AND THE WARINESS OF THE WORLD COMMUNITY
Authors: Кувырченкова Татьяна Владимировна , Черевко Владимир Владимирович
Published: March 2022

Рассматриваются нанотехнологии как перспективная область познания, имеющая прикладное значение; международные организации, предпринимающие усилия для обеспечения безопасности применяемых нанотехнологий и наноматериалов. Актуальность темы обосновывается недостаточностью правового регулирования, необходимостью совершенствования законодательства в этой сфере, возможными рисками для здоровья человека и безопасности окружающей среды и потребностью разработки системы тестирования и контроля в этой области.

The article considers nanotechnology as a promising field of knowledge with applied significance; international organizations making efforts to ensure the safety of applied nanotechnology and nanomaterials. The relevance of the topic is justified by the lack of legal regulation, the need to improve legislation in this area, possible risks to human health and environmental safety and the need to develop a testing and control system in this area.
SOME PROBLEMS OF THE PROSECUTOR'S PARTICIPATION IN COURT PROCEEDINGS IN CASES OF DEPRIVATION OR RESTRICTION OF PARENTAL RIGHTS
Authors: Гришанов Данил Александрович
Published: March 2022

Рассматриваются отдельные спорные и проблемные вопросы, связанные с участием прокурора в рассмотрении судами дел о лишении граждан родительских прав и ограничении в них. Предлагаются способы решения данных проблем с целью повышения эффективности функционирования указанного института гражданского процесса.

The article deals with some controversial and problematic issues related to the participation of the prosecutor in the consideration by the courts of cases of deprivation of parental rights of citizens and restrictions in them. The ways of solving these problems are proposed in order to increase the effectiveness of this institution of civil procedure.
HARGA DIRI DAN OPTIMISME TERHADAP WORK FAMILY ENRICHMENT PADA TENAGA KESEHATAN WANITA
Authors: Anggraini Dewi , Juniarly Amalia , Pratiwi Marisya
Published: March 2022

Penelitian ini bertujuan untuk mengetahui hubungan antara harga diri dan optimisme terhadap work family enrichment pada tenaga kesehatan wanita. Adapun hipotesis dari penelitian ini adalah ada hubungan harga diri dan optimisme terhadap work family enrichment pada tenaga kesehatan wanita. Populasi pada penelitian ini adalah tenaga kesehatan wanita di salah satu Rumah Sakit Umum Daerah di Kota X dengan jumlah sampel penelitian sebanyak 90 orang. Skala yang digunakan dalam penelitian ini adalah skala harga diri, skala optimisme dan skala work family enrichment. Skala tersebut diujicobakan terlebih dahulu pada 50 tenaga kesehatan wanita yang memiliki karakteristik yang sama dengan sampel penelitian.
GLOBAL CLIMATE CHANGE: TRENDS AND IMPLICATIONS FOR VIETNAM
Authors:   Southern Institute of Social Sciences of the Vietnam Academy of Social Sciences, Sang Le Thanh , Lukyanets Artem S. ,   Institute for Demographic Research FCTAS RAS, Garibova Farzona M. ,   Institute for Demographic Research FCTAS RAS
Published: March 2022

The modern scientific theory of global climate change has been developing for several decades, tens of thousands of scientific articles have been published. Climate change and its impacts are already visible in many parts of the world, and coastal areas are highly vulnerable to these changes. The Vietnamese government has foreseen the impact of climate change and has already taken various measures to control the impact of coastal hazards. However, with 3,200 km of coastline, Vietnam still suffers severely from damage caused by floods, erosion and typhoons each year. In addition, most of Vietnam's coastal areas are below 1 m in height, making them particularly vulnerable to the impacts of climate change and associated sea level rise. This article is devoted to the description of the consequences of climate change for Vietnam and analyzes their impact on the socio — economic and demographic situation of the country. The analysis of Vietnam's National Climate Change Strategy for the period 2011-2020 is presented. The study found that Vietnam faces potentially significant social and economic impacts in many regions and sectors. Without effective adaptation and disaster risk reduction efforts, multidimensional poverty and inequality are likely to increase.
ATTRACTING CAPITAL BY BIOTECHNOLOGICAL AND PHARMACEUTICAL CAPITALS: FEATURES OF THE EUROPEAN MARKET
Authors:   RUDN-University, Glavina Sofya G. , Aidrous Irina A.Z. ,   RUDN-University
Published: March 2022

The pharmaceutical industry is one of the most competitive sectors in the European Union. With significant investment in research and development, this industry is a key asset for the European economy and a major source of growth and employment. This article examines methods of raising capital for biotech and pharmaceutical companies. This paper also describes the impact of the COVID-19 pandemic on the biotechnology and pharmaceutical markets, identifies new trends in its development, as well as priority areas. Spread of the corona virus COVID-19 has created a multi-billion dollar market in the world and the EU in particular for vaccines needed to prevent the spread of the pandemic, rebuild the economy and begin the transition to a new paradigm of the growth. Particularly noteworthy there are the issues of raising capital through an initial public offering of securities — Initial Public Offering (IPO). At the beginning of the last decade, IPO markets were not receptive to biotech companies, but already in 2013 the situation changed dramatically. The increasing availability of private capital is making it more affordable to raise funds through IPOs, especially for the biotech and pharmaceutical industries.
TRANSFORMATION OF THE MIGRATION POLICY OF RUSSIA, KYRGYZSTAN AND KAZAKHSTAN DURING THE COVID-19 PANDEMIC IN THE CONTEXT OF EURASIAN INTEGRATION
Authors:   Institute for Demographic Research FCTAS RAS, Khramova Marina N. ,   MGIMO University, Skoblina Elena V. ,   MGIMO University, Tyshkevich Anna I. ,   Institute for Demographic Research FCTAS RAS,   MGIMO University
Published: March 2022

The migration policy of Russia, Kazakhstan and Kyrgyzstan is undergoing changes during the pandemic of the new coronavirus infection COVID-19. Its main aim is to mitigate the socio-economic effects of the pandemic for different categories of migrants, as well as to help migrants who remains at the territory of host countries. This article contains a brief chronology of the closure and gradual opening of state borders, the implementation of certain restrictive measures, requirements for crossing the state border by migrants. The article provides a description of measures aimed at supporting local population and migrants. Some data on the volume of money transfers as a factor of social stability in the countries of origin of migrants are presented. The diaspora aspect is also described, namely the situation of the Kazakh and Kyrgyz diasporas and the help they have received from the country of origin. The situation in the Russian Federation as a country, that is the main recipient of migrants of various categories for the CIS countries , is considered separately. It is shown that the set of measures adopted by the Russian Federation in the first months of the pandemic made it possible to avoid serious negative consequences on the labor market, as well as the marginalization of migrants. The article also provides an analysis of some of the documents that were adopted at the EAEU level during the first year and a half of the pandemic.
Aktivitas Urease dan Pembentukan Kalsium Karbonat oleh Bakteri Ureolitik
Authors: Linda Tetty Marta , Ningsih Mufidah Dwi Suci , Fibriarti Bernadeta Leni , Andini Saras , Futra Dedi
Published: March 2022

Bakteri ureolitik adalah bakteri yang memiliki aktivitas enzim urease yang menghidrolisis urea untuk menghasilkan karbondioksida dan amonia. Bakteri ini dapat diaplikasikan untuk agrikultur, kesehatan dan konstruksi. Penelitian ini bertujuan untuk melihat aktivitas urease Bacillus SP 34 dan Bacillus SP 83 dan kemampuannya menghasilkan kalsium karbonat. Pengujian aktivitas urease secara kuantitatif dilakukan dalam Nutrient Broth selama 18 jam. Produksi kalsit menggunakan medium NB-U/Ca inkubasi selama 7 hari.  Hasil penelitian diketahui Bacillus SP 34  aktivitas urease yaitu 0,058 U/ml dan kalsium karbonat terbentuk  169.0 mg dan Bacillus SP 83 dengan aktivitas urease 0.065 U/ml dan kalsium karbonat terbentuk 105.0 g.  Ke dua isolat ini dapat dikembangkan untuk bidang pertanian dan  konstruksi sebagai bahan campuran beton.
Classificação hierárquica das formas de relevo granítico na Unidade de Conservação Refúgio de Vida Silvestre (REVIS) Pedra Andorinha, Taperuaba, Sobral, CE.
Authors: Rodrigues José Marcos Duarte , Lima Ernane Cortez , Claudino-Sales Vanda
Published: March 2022

O relevo granítico mostra-se de forma expressiva na paisagem nordestina, devido sua maior resistência a processos naturais químicos e físicos. Na Unidade de Conservação Refúgio de Vida Silvestre Pedra da Andorinha, situada no distrito de Taperuaba, município de Sobral Ceará, a ocorrência dessas feições é bastante expressiva. Tais feições apresentam formas e tamanhos variados, evidenciando a atuação de processos em subsuperfície e em superfície após sua exumação. Dessa forma, a Teoria da Etchplanação associada com a compreensão dos processos morfodinâmicos, possibilitaram a análise do desenvolvimento dessas formas de relevo. Utilizando-se da literatura existente, trabalhos de campo e técnicas de geoprocessamento, classificou-se tais feições em macro e microformas, de acordo com suas características fisionômicas, gênese e desenvolvimento. Considerou-se como macroformas, o inselberg Pedra da Andorinha e os lajedos e/ou afloramentos verticalizados. As microformas foram subdivididas em feições associadas com meteorização, saprolitização e fraturamento. Foi possível distinguir e hierarquizar as feições graníticas de maneira produtiva, contribuindo para trabalhos posteriores que possam aprofundar-se na temática.Palavras-chave: Unidade de Conservação; Etchplanação; Feições graníticas. Hierarchical classification of granite landscapes in the Pedra da Andorinha Conversation Unit and Wildlife Refuge, Taperuaba, Sobral, CE A B S T R A C TGranite landscapes are extensively found in the Brazilian Northeast, due to their greater resistance to chemical and physical natural processes. At Pedra da Andorinha Conservation Unit and Wildlife Refuge, located in the district of Taperuaba, municipality of Sobral, State of Ceará, the occurrence of these features is very expressive, with varied shapes and sizes, showing the action of processes in the subsurface and surface after its exhumation. Associated with the understanding of morphodynamical processes, the etchplanation Theory allows for the analysis of the development of these landforms. From the existing literature, field work and geoprocessing techniques, the features were classified in macro and microforms, according to their physiognomic characteristics, genesis and development. The Pedra da Andorinha inselberg and the cliffs and/or vertical outcroppings were considered macroforms. The microforms were subdivided into features associated to weathering, saprolitization and fracturing. It was therefore possible to distinguish and hierarchize the granitic features in a convenient way, contributing to further works that can deepen the approach to the theme.Keywords: Conservation Unit; Etchplanation; Granite landscapes.
Reflexos Ambientais do Desenvolvimento e Expansão das Atividades Humanas sobre a Qualidade da Água
Authors: Lourenço Roberto Wagner , Sales Jomil Costa Abreu , Arantes Leticia Tondato , Silva Camille Vasconcelos , Silva Darllan Collins da Cunha e
Published: March 2022

Os recursos hídricos são submetidos a inúmeras mudanças ao longo dos anos por processos naturais ou induzidos pelo homem. Nesse cenário, destacam-se as atividades agrícolas e a urbanização que provocam uma série de efeitos negativos no ambiente, contribuindo para o processo de degradação e mudanças na qualidade da água. Portanto, o objetivo desse estudo foi analisar a influência da expansão antrópica e o índice de desenvolvimento humano sobre a qualidade da água na Bacia Hidrográfica do Rio Una, visando identificar a relação existente entre esses componentes. Assim, esta pesquisa contribui de forma metodológica através da análise desses índices associados as ferramentas de geotecnologias para estudos ambientais. Foi constatado que a bacia possui a agricultura como a principal fonte de renda, bem como um processo contínuo da expansão das áreas urbanas, o que coopera com o estabelecimento das atividades antrópicas ao longo dela, afetando na qualidade da água. A maior parte da bacia foi caracterizada com um alto índice de desenvolvimento humano, o que exerce certa influência acerca da qualidade dos recursos hídricos. Por fim, notou-se a presença de níveis de fosforo mais alto que o regulamentado, podendo ser justificado em função das atividades antrópicas provenientes das atividades agrícolas e urbana.Palavras-chave: geoprocessamento, desenvolvimento humano, qualidade da água, análise espacial.Environmental reflections of the development and expansion of human activities on water qualityA B S T R A C TWater resources are subject to numerous changes over the years by natural or human-induced processes. In this scenario, agricultural activities and urbanization stand out, which cause a series of negative effects on the environment, contributing to the process of degradation and changes in water quality. Therefore, the aim of this study was to analyze the influence of human expansion and the human development index on water quality in the Una River Basin, in order to identify the relationship between these components. Thus, this research contributes methodologically through the analysis of these indices associated with geotechnological tools for environmental studies. It was found that the basin has agriculture as the main source of income, as well as a continuous process of expansion of urban areas, which cooperates with the establishment of human activities along it, affecting water quality. Most of the basin was characterized with a high human development index, which exerts some influence on the quality of water resources. Finally, it was noted the presence of phosphorus levels higher than the regulated, which can be justified in terms of human activities from agricultural and urban activities.Keywords: geoprocessing, human development, water quality, spatial analysis.
Caracterização morfométrica da microbacia hidrográfica do Açude Grande no semiárido do Rio Grande do Norte
Authors: Lopes Jessica Rafaelly Almeida , Bezerra Joel Medeiros , Almeida Natália Maria Diniz Pereira , Costa Helves Cleverton Guerra , Fernandes Gabriel Siqueira Tavares , Gonçalves Gustavo Leite , Mendonça Sarah de Souza Cruz , Júnior Marcos Elias de Oliveira
Published: March 2022

Os estudos morfométricos auxiliam no planejamento e gerenciamento de microbacias hidrográficas, determinando os parâmetros fisiográficos, de relevo e drenagem para avaliar o comportamento hidrológico da bacia. O presente estudo teve por objetivo caracterizar a morfometria da microbacia hidrográfica do Açude Grande de Caraúbas/RN. Foram utilizados para a delimitação automática da bacia o Modelo Digital de Elevação (MDE), a partir do projeto TOPODATA, obtido junto ao Instituto de Pesquisas Espaciais (INPE) e utilizado o SIG gratuito e de linguagem aberta QGIS, com auxílio dos plugins do GRASS e do SAGA, possibilitando a determinação de parâmetros que remetem a drenagem, forma e relevo. A microbacia possui uma área de 9,706 km2, perímetro de 20,673 km. De acordo com os índices morfométricos é considerada de 4ª ordem, bastante ramificada, de formato pouco alongado, apresenta pequena tendência a grandes enchentes, o relevo correspondeu de plano a suave ondulado. Com isso, a partir do emprego de ferramentas geotecnológicas contribuindo para o zoneamento ambiental de uma área e podendo cooperar para o gerenciamento dos recursos hídricos, bem como para uso e ocupação do solo de forma sustentável.Palavras-chave: diagnóstico, geotecnologias, sensoriamento remoto.                                                                                                                                 Morphometric characterization of the Açude Grande hydrographic microbasin in the semiarid region of Rio Grande do Norte A B S T R A C TMorphometric studies assist in the planning and management of micro watersheds, determining the physical, relief and drainage parameters to assess the hydrological behavior of the basin. The present study aimed to characterize the morphometry of the micro watershed of Açude Grande, Caraúbas/RN. The Digital Elevation Model (DEM) was used to automatically delimit the basin, from the TOPODATA project, from the Space Research Institute (SRI) and use the free GIS and the open language QGIS, with the aid of the SAGA plugin. A micro watershed has an area of 9.706 km2, with a perimeter of 20.673 km. According to the morphometric indices, it is considered to be of 4th order, quite branched, of little elongated shape, with small tendencies to large fillings, or the relief corresponds to a smooth wavy plane. With this, using geotechnological tools to contribute to the environmental zoning of an area and can cooperate for the management of water resources, as well as for the use and occupation of sustainable soil.Keywords: Environmental diagnosis; Geotechnologies; Morphometry.
Design characteristics of the strength of VKS-9M and 300M steels
Authors: Kablov E. N. , Grinevich A. V. , Slavin A. V. , Kabanov I. V. , Gromov V. I. , Ampilogov A. Yu. , Yakovlev N. O. , Polyakov A. N. , Yakusheva N. A.
Published: March 2022

The mechanical properties of square section (up to 350 mm) forgings made of domestic steel VKS-9M (obtained by the duplex process of vacuum induction melting plus vacuum arc remelting) are studied. The mechanical properties of steel VKS-9M and American high-strength structural steel 300M are compared in terms of the calculated characteristics of materials. We extend the concept of «design characteristics of materials» to all the mechanical properties of materials used in determination of the strength and durability of structures. The design characteristics of materials include the strength characteristics under quasi-static tension, compression, crushing and shearing, as well as the strength under variable loads and the crack resistance of the material. The correctness of comparing the calculated values of the static strength of steels VKS-9M and 300M is based on the identity of test methods and the equivalence of processing and presentation of test results. The determination of the strength characteristics was carried out according to domestic standards, which are basically harmonized with the American standards. A difficult situation arises when determining the strength indicators of a newly developed material. Nowel material, as a rule, is developed in laboratory conditions, produced on experimental equipment in small volumes, and, therefore, the statistical assessment of the general population at the development stage is unreliable. In conditions of the full-scale manufacture of industrial semi-finished products, a statistical assessment of their strength characteristics becomes necessary. In the aviation industry, a statistical assessment of the calculated values of the strength characteristics of the material is prescribed by the law. The airworthiness standards set the levels of the calculated values of strength characteristics with a certain probability of non-destruction. For parts, the destruction of which can lead to an accident, the calculated values of the strength characteristics of materials should be selected in such a way that the strength of the material is to be ensured with a probability of 99% — with a 95% confidence interval (basis «A»). Statistical evaluation of the static strength characteristics of two heats of VKS-9M steel on the basis of «A» revealed their insignificant excess in comparison with steel 300M. The data obtained allow us to believe that the calculated values of the static strength characteristics of VKS-9M steel will not be lower than the calculated values for 300M steel. Large-scale fatigue tests of VKS-9M steel were carried out, which proved that the fatigue characteristics of VKS-9M and 300M steels practically coincide, as well as the arrays of their determinations. The equivalence of the strength characteristics of the VKS-9M and 300M steels allows replacement of the American 300M steel by the domestic VKS-9M steel.
Long-term follow-up of young children and adolescents with parental alcoholism who attended a group support programme for children 1993-2000
Authors: Zetterlind Ulla , Lauridsen Susanne Vahr , Rasmussen Mette
Published: March 2022

Introduction  The aim was to follow-up children, of parents with alcohol problems, who joined a group support programme in Malmö, Sweden from 1993–2000. Our intension was to investigate mental health and social well-being in these children over a long period of time. Method  Two follow-ups were conducted, in 2003 and in 2018. In 2003 the follow-up, included a semi-structured interview and six self-report scales (SCL-90, Coping with parent´s abuse, Social interaction, AUDIT, DUDIT and a Stress questionnaire). In 2018 the same scales were used, complemented with the EQ5D questionnaire and a standardized life situation formula. Results  In 2003, 50% of the 44 attendees worked full-time or part-time. However, sons showed higher values on AUDIT and DUDIT (alcohol and drug use). In 2018, half of the 25 attendees had continued to study. Coping, AUDIT and social interaction changed significantly over time, coping and AUDIT for the better. The EQ5D showed lower quality of life compared to the normal Swedish population, and the life situation questionnaire revealed high levels of stress. Conclusion  Most attendees had completed their school education, and half of them reported further studies. However, in the 2018 follow-up, they showed increased mental and physical symptoms.
A new theory on the shape of the universe and the origin of the time
Authors: Marcel Julmard Ongoumaka Yandza
Published: March 2022

In this article, we have made a theoretical research, at the limit of the scientiﬁc reﬂection, to respond to the following query: what is the origin of the time? To ﬁnd the response to this question, we adopted an attractive method. First, we have considered the light physical characteristics (speed, energy...) as the invariants. On this basis, we characterized all other physical systems by referring to the light. By this scheme, we showed that the calculation of the absolute physical characteristics of any system comes compulsory by the light viewpoint. That method avoids the use of mathematical transformations like Lorentz transformation; which is used in relativity to make invariant the equations by the change of the system of reference. Second, we made other hypothesis to ﬁnd a law characterizing the interactions between matter and antimatter. Third, we used these interactions to quantify the time. The central query of this research led us to the shape of the universe and its volume. Finally, we found that the universe is a conical shape.
Sampling Bias in Ethnobotanical Studies on Medicinal Plants Conducted in Local Markets
Authors: Silva Jonathan Garcia , de Almeida Caetano Roberta , Vasconcelos da Silva Rafael Ricardo , de Medeiros Patrícia Muniz
Published: March 2022

Studies have identified the strong presence of sampling bias in ethnobiological research, which may seriously compromise study results. However, these studies were made in the context of Brazilian studies and global sampling evaluations are still needed. The present study adopted a global scale and was based on ethnobotanical surveys of medicinal plants in open fairs and markets. We aimed to assess sample quality and to identify the factors that interfere with it. Among the factors we investigated were how the (a) year of publication, (b) CiteScore, (c) presence of a clear research question, (d) presentation of hypotheses, and (e) the use of ethnobotanical indices influences the presence of sampling bias. The main source of bias verified in the studies was the absence of information about the sample and the population. None of the variables tested interfered with the level of bias of the studies. Efforts are needed to correct quantitative studies regarding sampling procedures, and the peer-review exercise in scientific journals should be attentive to sampling bias.
Entangled with Antlers on the Iamal Peninsula of Arctic Siberia
Authors: Nomokonova Tatiana , Losey Robert J. , Razdymakha Stella E. , Okotetto Stanislav , Plekhanov Andrei V. , Gusev Andrei V.
Published: March 2022

Indigenous communities living in the Iamal-Nenets region of the Arctic Siberia incorporate reindeer antlers into various aspects of their lives, at times in remarkable ways. This is especially the case for Nenets herding families, who closely interact with domestic reindeer on a daily basis. Antlers for Nenets are not just raw materials for producing tools, but rather a part of their perceptions of time, clothing designs, gendered skills and spaces, and physical manifestations of pride. This article links current Nenets entanglements with antler to similar material practices on the Iamal Peninsula during the Iron Age. To accomplish this, we incorporate multi-generational Nenets knowledge into the analysis of modified and unmodified antler recovered during excavations of Iarte VI, an Iron Age archaeological site located on the tundra of the Iamal Peninsula. Our approach is founded upon direct engagement and collaboration with Nenets families from the Iamal region. Together, we focus on identification of reindeer age and sex through visual assessment of antler objects from Iarte VI. We also explore antler shapes and growth cycles, working qualities, and placement within and outside dwelling areas at the site. This collaborative approach sheds light on site seasonality, the ages and genders of the inhabitants of Iarte VI, and several longstanding continuities in antler practices.
EFFECT OF RESPONSIBILITY ACCOUNTING APPLICATION AND STRATEGY IMPLEMENTATION TOWARD CORPORATE PERFORMANCE
Authors: Diah Rani Nartasari
Published: March 2022

In the current globalization era, many more business competition and the global economic situation was uncertain that requires management to be more active and more creative and able to cope problems that exist, so that the company can still go on to live and grown. Every company is required to have a differentiation advantages that can be used as an additional weapon to deal with competitors. That company's readiness to face the threats and challenges that will arise is through the formulation and implementation of appropriate strategies that align with the core excellence. The purpose of this study was to examine and analyze the relationship between the application of responsibility accounting and strategy implementation with corporate performance. The population of this study was all of branch manager of PT. CLASIES STAR PROBOLINGGO in Indonesia, amounted 130 peoples. The sampling technique was conducted with a "non-probability sampling" approach with "purposive sampling" method. Model of analysis that used to test the hypothesis is multiple linear regressions and to determine their effects are using F-test and t-test.