bluuebunny/crossref_metadata_2025 huggingface dataset:
Attenuated APC contributes to FGF12 expression and EC progression with an integrated multi-omics analysis
Authors: Song Yunfeng , Zhong Cheng , Hu Xiang , Huang Jian , Bian Yiding , He Qizhi , Li Yiran
Published: February 2023

BackgroundEndometrial cancer (EC) is one of the most common gynecological cancer worldwide. The high-order chromatin structure plays an important role in gene expression regulation. In our previous research, the chromatin remodeling-related gene APC (adenomatous polyposis coli gene) is frequently mutated in endometrial cancer. In this study, we aimed to figure out the role of the APC gene in the chromatin remodeling of endometrial cancer and cancer progression.ResultsThe level of APC expression decreased in EC and cell migration assays revealed that APC know-down KLE cells showed increased cell migration ability. An integrated multi-omics analysis, including RNA-sequencing (RNA-seq), assay for transposable accessible chromatin by high-throughput sequencing (ATAC-seq) and Hi-C, between the control cell and APC and knockdown KLE cell was performed and revealed that FGF12 was identified as a differentially expressed gene (DEG) in the switched compartments, cell-specific boundaries, and loops by comparing hierarchical structures and highly expressed in APC knockdown KLE cells. Moreover, high expression of FGF12 indicated a poor prognosis.ConclusionsAPC expression decreased in EC tissues and loss of APC in EC promotes cell migration. Moreover, loss of APC gene expression may reprogram the chromatin architecture to increase FGF12 gene expression, activate tumorigenesis-rated AKT and MAPK (Erk1/2) signaling, and promote endometrial cancer progression. In addition, a high level of FGF12 expression indicated a poor prognosis in EC patients, which provides a novel therapeutic target for EC with low expression level APC.
UBR4 deficiency causes male sterility and developmental delay
Authors: Xie Shi-Ming , Lai Jia-Xuan , Liu Chu-Qiao , Zhang Xi-Xing , Lin Yong-Miao , Chen Xiao-Chuan , Qiao Jing-Da , Mao Yu-Ling
Published: February 2023

It has been established that UBR4 encodes E3 ubiquitin ligase, which determines the specificity of substrate binding during protein ubiquitination and has been associated with various functions of the nervous system but not the reproductive system. Herein, we explored the role of UBR4 on fertility and development with a drosophila model. Different UBR4 knockdown flies were established using the GAL4/upstream activating sequence system. Fertility, hatchability and testis morphology were studied, and bioinformatics analyses were conducted. Our results indicated that UBR4 deficiency could promote larvae developmental delay and male drosophila fertility. We found that UBR4 deficiency affected the testis during morphological analysis. Bioinformatics analysis indicated 188 upregulated proteins and 175 downregulated proteins in the testis of UBR4 knockdown flies. Gene Ontology analysis revealed that significant upregulation of Sfp65A and downregulation of Pelota were involved in the reproductive process in drosophila, important in testis generation and sperm storage promotion. Overall, our findings suggest that UBR4 deficiency could promote male infertility in drosophila and may be involved in the protein modification of UBR4 by upregulating Sfp65A anddownregulating Pelota protein expression.
Assessing Knowledge and Awareness of Thromboprophylaxis before surgical intervention, among senior year medical students at Syrian private university (SPU)- a cross sectional study.
Authors: Aljasem Zahraa , Alraqmani Najwa
Published: February 2023

Background
Venous thromboembolism (VTE) is a major public health challenge globally due to its high morbidity and mortality. The condition is often asymptomatic and underdiagnosed due to la ack of awareness of VTE risk factors and thromboprophylaxis.
Methods
This cross-sectional study was conducted in April 2022 using an appropriate sampling pattern among students of the Faculty of Medicine at the Syrian Private University. A self-administered questionnaire was used. Ethical approval was obtained from the Institutional Review Board (IRB), Faculty of Medicine, Syrian Private University.
Results
The sample in our study consisted of 140 students, where awareness was surveyed about the use of venous thrombosis prevention before surgery. be without clinical symptoms 94 students answered “yes” (67%), the largest number of students knew that prolonged immobilization “predisposes to deep venous thrombosis in hospitalized patients” by 94%, and the largest number of students answered that obesity may lead to venous thrombosis Deep venous thrombosis with a percentage of 94%, 105 students answered yes when asked whether intravenous catheters could predispose to deep venous thrombosis by 75%, and when asked whether venous thrombosis was a sudden cause of death in hospitalized patients, 86 students answered yes with a percentage of 61%, and when asked as to whether prolonged hospitalization may increase predisposition to developing deep vein thrombosis by 8-fold, the largest number of students, 106, answered yes by 76%.
Conclusion
The results of our study conclude to an acceptable degree of awareness among medical students in the Syrian Private University regarding thromboprophylaxis.
Mikro İnsansız Hava Aracı İçin Batarya Tüketim Modelinin Elde Edilmesi
Authors: ÇAŞKA Serkan , GÖKÇE Barış
Published: February 2023

İnsansız hava araçları günümüzde insanlar için tehlikeli ve zahmetli olabilecek birçok uygulamada kullanılmaktadır. Bu araçların kullanım alanını kısıtlayan en büyük etkenlerden biri batarya kapasitelerinin birçok uygulama için yeterli olmamasıdır. Son yıllarda, bu kısıtın ortaya çıkardığı zorlukları en aza indirmek için insansız hava araçlarının farklı etkenler altında batarya tüketimlerinin nasıl gerçekleştiğine dair çalışmalar olmuştur. Bu çalışmada mikro sınıfında bir insansız hava aracının yatay düzlemde farklı hızlarda hareket ettirilmesi durumunda oluşacak batarya tüketim değerleri deneysel olarak elde edilmiştir. Batarya tüketimine ait veriler kullanılarak doğrusal regresyon ve doğrusal olmayan regresyon yöntemleri ile batarya tüketim modelleri elde edilmiştir. Deneysel veriler ve modellerin başarısını gösteren sonuçlar tablo ve grafik halinde sunulmuştur.
Przedszkole bliżej natury – ścieżka przyrodnicza jako odpowiedź na potrzeby rozwojowe dziecka
Authors: Pawłowicz-Sosnowska Ewa , Sobczuk Sebastian
Published: February 2023

Celem opracowania jest próba ukazania wyzwań i zalet edukacji w przyrodzie, realizowanej w ramach ścieżki przyrodniczej, w odpowiedzi na problematykę dotyczącą kształtowania realnych postaw i zachowań względem przyrody, a także wynikających z ich braku deficytów rozwojowych u dzieci w wieku przedszkolnym. Materiał do niniejszego opracowania powstał jako efekt prac badawczych przeprowadzonych w Przedszkolu Samorządowym nr 13 w Białej Podlaskiej. Analiza otrzymanych wyników badań pozwoliła potwierdzić potrzebę powrotu do przyrody w wychowaniu przedszkolnym.
Potrzeba dialogiczności w pracy nauczyciela wychowania przedszkolnego
Authors: Solak Adam
Published: February 2023

Dialogiczność nauczyciela wychowania przedszkolnego stanowi pedagogiczny obszar do namysłu dla wielu autorów zajmujących się pedagogiką dialogu czy praktycznych badań na temat współpracy oraz komunikacji. Dialog stanowi fundament należytego i twórczego etosu nauczyciela wychowania przedszkolnego. Prezentowany artykuł ukazuje owo zagadnienie na płaszczyźnie: nauczyciel–uczeń, nauczyciel–rodzic, nauczyciel–nauczyciel oraz nauczyciel–środowisko wychowawcze. Te cztery obszary, w których obecny jest proces dialogu, są gwarantem nie tylko ładu społecznego, lecz przede wszystkim godnościowego i należytego rozwoju dziecka i właściwych relacji w środowisku przedszkolnym.
Laser delivery and spectral study of a modern chlorine-containing drug for the treatment of onychomycosis at laser radiation with a wavelength of 450 nm
Authors: Belikov A. V.  , Fyodorova Y. V.  , Kozlova A. D.  , Smirnov S. N.
Published: February 2023

The possibility of active laser delivery of a modern chlorine-containing photosensitizing drug Chloderm (Chloderm, Russia) under the nail plate by laser radiation with a wavelength of 450 nm for the purpose of photodynamic therapy of onychomycosis is studied. In an in vitro experiment, sequential laser microporation of the nail plate and active delivery of the drug under the nail plate by this laser radiation with an intensity of up to 200 W/cm2 were investigated. The results of studying the absorption spectra of an aqueous solution of Chloderm in the range of 400-900 nm before and after exposure to 450 nm laser radiation are presented. It is demonstrated that sequential laser microporation and active laser drug delivery under the nail plate is possible at laser radiation intensity greater than 178 W/cm2. It is shown that the maximum rate and efficiency of nail plate ablation by 450 nm laser radiation is achieved at an intensity of 200 W/cm2 and is 2750± 30 μm/s and 1.47 ± 0.05 μm/mJ, respectively. The delivery rate of Chloderm under the nail plate is 1.15± 0.1 mg/s. It is shown that exposure to 450 nm laser radiation at the intensity of 200 W/cm2 for a time sufficient to deliver the drug under the nail plate does not change the extinction coefficient of the drug at the laser wavelength and slightly changes the conformational state of Chloderm. Keywords: laser delivery, ablation, wavelength, absorption coefficient, chlorine-containing photosensitizing drug, laser radiation.
Spinor representation of the double group of Icosahedron and entangled states of fullerene C-=SUB=-60-=/SUB=- wave functions
Authors: Sukharev A. G.
Published: February 2023

Symmetry of the icosahedron group is a basic principle producing the analytical description of the fullerene by means of the theory of molecular orbitals. Further development of the fullerene model requires consideration of the half-integer statistics of the electron states. Double group of the icosahedron describes both statistics cases, but we use only fermions case, in other words, the spinor representation of the icosahedron group. In this representation, it is possible to remove restriction defining the parity of the wave function coordinate part and to build a table of characters for arbitrary meaning of the total momentum. Symmetry of the icosahedron produces algebraic structure of the residue ring on the modulo 5, when using momentum projection on chosen axis. If the momentum projection equals both ± 5/2 the states come into one representation. If the momentum projection by absolute value is higher 5/2, the wave function occupies state with several entangled spinor. Keywords: Double group of the icosahedron, irreducible representations, spinors, spin-orbit interaction, entangled states
Features of Raman scattering in lead sulfide and lead sulfide-selenide epitaxial films
Authors: Fedorov A.V.  , Baranov A.V.  , Zimin S.P.
Published: February 2023

Raman scattering spectra of 1-2 μm thick n-PbS(111) epitaxial films grown by molecular beam epitaxy on BaF2(111) substrates were obtained and analyzed. The spectra were recorded at a low excitation level of 0.36 mW/μm2, which did not cause photo- and thermal degradation of the films. It is shown that, in accordance with the symmetry selection rules, the bands in the spectra correspond to overtone or combination tones of phonon modes of PbS at special points of the Brillouin zone. The analysis of the bands of oxides and oxysulfates of lead, which can mask the bands of lead sulfide, was carried out. The obtained data were used in the analysis of the recorded Raman scattering spectra by epitaxial films of a ternary solid solution PbS0.5Se0.5. Keywords: Raman scattering, low excitation level, photooxidation, epitaxial films, lead sulfide, lead sulfide-selenide.
Ir transparency of thin bismuth films
Authors: Shamparov E. Yu.  , Bugrimov A. L.  , Rode S. V.  , Jagrina I. N.
Published: February 2023

The infrared transmission and reflection spectra of a series of samples of bismuth films of different thicknesses on identical single-crystal silicon substrates were measured. Transmission and reflection oscillations caused by interference on the film thickness are investigated. Properties of Si-plates are estimated. Refractive index and absorption index of bismuth are calculated. Keywords: bismuth, film, IR, interference.
Влияние длины искусственного надреза в композиционном материале на величины индикаторов повреждаемости
Authors: Дзюба А.С. , Елеонский С.И. , Писарев В.С. , Яшутин А.Г.
Published: February 2023

Novel experimental method, which provides visualization of interference fringe patterns caused by inserting of artificial notch of prefixed length in composite material, is developed. Deformation response to local material removing is measured by electronic speckle-pattern interferometry. Interferogram interpretation in terms of in-plane displacement components produces determination of two deformation parameters. These parameters represent current damage indicators, which are essential for quantitative description of damage accumulation inherent in fatigue loading of specimens with stress concentrators. Both damage indicators are derived on a base of direct physical measurements by fringe order counting. Analysis of uncertainties in damage indicators determination, which are connected with incorrect prescribing of artificial notch length, is presented.
Estatus sanitario en pequeños sistemas productivos piscícolas de tilapia en el municipio de San Carlos, Antioquia
Authors: Correa Agudelo Lina , Ramírez Guerra Alejandro , Pérez-García Janeth , Arango Vacares Francisco José
Published: February 2023

Las medidas de prevención y control sanitario en sistemas productivos piscícolas de tilapia son un reto para los pequeños productores campesinos en Colombia. El objetivo de este trabajo consistió en identificar in situ el estado sanitario de pequeños centros de producción de tilapia en el municipio de San Carlos, Antioquia. Se realizaron análisis macro y microscópico de 140 peces, se tomaron muestras de los principales órganos y se evaluó Streptococcus agalactiae, S. iniae, y Edwardsiella tarda a través de pcr. Se tomaron tres peces por producción y se determinó la presencia de Escherichia coli en filete. Además, se evaluó la concentración de oxígeno disuelto, la temperatura, los sólidos totales disueltos, la salinidad, la conductividad, el pH y la presencia microbiológica de E. coli y coliformes totales en agua. Por su parte, los hallazgos macroscópicos evidenciaron anormalidades en ojos, riñón posterior e hígado. Los microorganismos hallados fueron: monogéneos (53,9 %), tricodínidos (29,1 %) y Epistylis (7,8 %). Los peces con monogéneos presentaron un peso y una longitud mayor que aquellos negativos (p = 0,017 y 0,045, respectivamente) y lesiones en branquias en mayor proporción (rp = 1,56, ic95 % 1,17-2,06, p = 0,006). La presencia de tricodínidos presentó una relación estadísticamente significativa con el pH, la conductividad y la concentración de sal, además, las pruebas moleculares fueron negativas. La información generada puede utilizarse para plantear acciones zootécnicas y sanitarias para mejorar el estatus sanitario de los sistemas productivos de tilapia en San Carlos.
Studies of Social Anxiety Using Ambulatory Assessment: Systematic Review (Preprint)
Authors: Fernández-Álvarez Javier , Colombo Desirée , Gómez Penedo Juan Martín , Pierantonelli Maitena , Baños Rosa María , Botella Cristina
Published: February 2023

BACKGROUND

There has been an increased interest in understanding social anxiety (SA) and SA disorder (SAD) antecedents and consequences as they occur in real time, resulting in a proliferation of studies using ambulatory assessment (AA). Despite the exponential growth of research in this area, these studies have not been synthesized yet.

OBJECTIVE

This review aimed to identify and describe the latest advances in the understanding of SA and SAD through the use of AA.

METHODS

Following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, a systematic literature search was conducted in Scopus, PubMed, and Web of Science.

RESULTS

A total of 70 articles met the inclusion criteria. The qualitative synthesis of these studies showed that AA permitted the exploration of the emotional, cognitive, and behavioral dynamics associated with the experience of SA and SAD. In line with the available models of SA and SAD, emotion regulation, perseverative cognition, cognitive factors, substance use, and interactional patterns were the principal topics of the included studies. In addition, the incorporation of AA to study psychological interventions, multimodal assessment using sensors and biosensors, and transcultural differences were some of the identified emerging topics.

CONCLUSIONS

AA constitutes a very powerful methodology to grasp SA from a complementary perspective to laboratory experiments and usual self-report measures, shedding light on the cognitive, emotional, and behavioral antecedents and consequences of SA and the development and maintenance of SAD as a mental disorder.
A Rhetorical Study of News Headlines Translation
Authors: Liu Yanwen
Published: February 2023

News report has become an important source for people to obtain information, and as the “eye” of a piece of news, the title highly summarizes its theme, and expresses the attitude of the author. By analyzing the relevant literature, it is found that most of the current studies focus on the stylistic characteristics and translation principles of news translation. The studies on news headline translation are limited. Besides, the researches on the translation of news headlines mainly focus on the characteristics and specific translation methods. Few studies focus on rhetorical strategies of news headlines translation. Therefore, literature research and qualitative analysis will be adopted to study the translation of news headlines from the perspective of rhetoric. By selecting a certain amount of news headlines translation, to the paper explores the news headlines translation from the rhetoric appeals and a rhetorical model for guiding the translation of news headlines has been given. This study finds that the three rhetorical appeals have certain guiding significance for news headlines translation. In terms of ethos, the translator enhances the audience’s sense of credibility in the news by stating the views of authoritative people or platforms, or quoting the words in authoritative works; in terms of pathos, the translator takes “audience” as the center. Understanding the audience better and sharing common grounds with them is helpful to complete the persuasion to the audience; in terms of logos, the translator improves the language expressions and their internal logic so that the audience can be effectively persuaded. The rhetorical model put forward provides a new perspective for the translation of news headlines. In addition, this study expands the horizons of news translation research, and has certain reference significance for news translation practice.
Doria, Pedro. Fascismo à brasileira: como o integralismo, maior movimento de extrema-direita da história do país, se formou e o que ele ilumina sobre o bolsonarismo. São Paulo: Planeta, 2020.
Authors: Schargel Sergio
Published: February 2023

Reseña del libro: Doria, Pedro. Fascismo à brasileira: como o integralismo, maior movimento de extrema-direita da história do país, se formou e o que ele ilumina sobre o bolsonarismo. São Paulo: Planeta, 2020.Fascismo à brasileira, de Pedro Dória, aproveita a onda de livros sobre recessão democrática para discutir, por meio de técnicas de New Journalism, a relação entre Integralismo e Bolsonarismo. Esta resenha discute alguns elementos-chave que aparecem no trabalho, em vista a iluminar os aspectos positivos e negativos da abordagem de Dória. Em que pese a escrita fluída do autor, transformando uma discussão densa em um estilo de prosa analítica, o livro não adentra em profundidade pontos essenciais desses movimentos de extrema-direita, e tangencia a relação que se propõe a fazer.
Development of SmartTrack with Authentication for Tracking Objects Business Promotion
Authors: Pendyala Prakyathi , Gajula Sri Harsha , Varanasi Aruna
Published: February 2023

Abstract: One of the most important and difficult duties of a smart video surveillance system is object tracking. The major purpose of this is to pinpoint the precise location of a specific item and to highlight that location with a buzzer and light. We considered secrecy when designing. We must protect the private documents. Therefore, we need to offer users permission before granting access to the location, buzzer, and light. This system was specifically created with authorization and confidentiality in mind. The various object tracking techniques that the researchers used are thoroughly reviewed in this publication. The purpose of this essay isto review numerous ways to object tracking and to examine, study, and evaluate them
Instructional Leadership of School Heads in The New Normal: Basis For Enhancement Program
Authors: Rivera Jocelyn O.
Published: February 2023

Abstract: The study aimed to assess the instruc tional leadership of school heads in the new normal in the Division of Rizal during the school year 2020 - 2021. This study is limited to the public secondary school heads in the Division of Rizal. The researcher selects forty (40) school heads as the respondents of the study. Purposive sampling technique was used in determining the respondents. The study used the descriptive survey research utilizing the researc her made instrument.
A Survey on Student Grievance Redressal System
Authors: Meshram Er. Ashwini , Palandurkar Vedanti , Zade Harshal , Masram Akash , Manmode Nikita
Published: February 2023

Abstract: Student satisfaction is a major concern throughout the institute. However, many times students cannot express their concerns. That eventually results in student dissatisfaction. Hence, to solve this problem a student grievance cell system is useful and it deals with student issues and grievances. The student can lodge their complaints through this system which will be redressed by the institute. The student grievance cell is where students can make a complaint without fear of accomplishment and discrimination and ask for help if there is any problem. A student grievance cell is a group of people who are there to help students struggling academically and emotionally. Students can approach the cell to express their concerns regarding academic matters ,health services, libraries, and other services. It also provides support and resources to students so they can talk about their issues. The student grievance cell will also focus on harassment issues, creating a protective environment for students. The student grievance redressal system is designed to provide an easy-to-use interface for students to register their complaints and track their progress. The system is equipped with features such as notifications, reporting, and analysis to improve the overall efficiency and effectiveness of the grievance redressal process. The system is designed to be user-friendly, making it easy for students to navigate and access all the necessary information. One of the key features of the system is the ability to track and monitor the progress of each complaint.This helps to ensure that all complaints are addressed in a timely and efficient manner, and that students are kept informed of the progress of complaint slain. The system is also equipped with reporting and analysis tools to help university administrators understand the nature and frequency of complaints and make informed decisions to improve the educational experience for students
Effectiveness of Evaluation Methods and Process of Identifying Students with Learning Disabilities: “A ase Study of USA and Zambia”
Authors: Moffitt Sabrina
Published: February 2023

Abstract: This study is done to draw a comparative analysis between the evaluation process for special education needs among primary education students in the USA and Zambia. The paper studies the effectiveness of the evaluation methods and the processes of identifying students with learning disabilities in both the countries of the USA and Zambia. There is no appropriate definition for learning disability but in the most basic way, it can be said that learning disability is a term that is used to describe many different neurological disorders. It is the consequence of impairments in one or more processes that is related to perceiving, thinking, remembering, or even learning. The mechanisms of the children with learning disabilities are just as same as normal kids, it is just that their brains are wired differently. This difference in their brain affects how they receive and process information. These disorders are not curable, it is a lifelong issue. Children with learning disabilities are taught by special education which is a practice of educating students in such a way that their individual differences and their special needs can be addressed. With the help of proper support and intervention, children suffering with learning disabilities can get success in their academic field and get distinguished careers later in life.
Lung Cancer Detection using Fusion, CNN and YOLO in MATLAB
Authors: Vats Parth , . Tejas , Vats Ritu , Dahiya Geeta
Published: February 2023

Abstract: Lung Cancer is one of the major causes of deaths in India. Various data analytics and classification approaches have been used to diagnose and find lung cancer in numerous cases. Lung Cancer can only be cured by early tumour diagnosis because the basis of the diseases is yet unknown, making prevention impossible. In order to classify the existence of lung cancer/tumour in a CT picture and PET image, a lung cancer detection method using image processing and deep learning is applied. Using Fusion technique, we first obtain CT scans, then PET images of the same patient, then combine both images into one. The classification carried out using image feature extraction. As a result, the combined CT and PET scan images of the patient are classified as normal or abnormal. The tumour component of the abnormal photos is the focus of the detecting process. Using YOLO and CNN, an effective strategy to identify lung cancer and its phases is one that also seeks to produce more precise results.
The project-based learning model and its contribution to life skills in biology learning: A systematic literature network analysis
Authors: Hizqiyah Ida Yayu Nurul , Nugraha Ikmanda , Cartono C. , Ibrahim Yusuf , Nurlaelah Ilah , Yanti Meily , Nuraeni Siti
Published: February 2023

This review examines the potential of Project-Based Learning (PjBL) to enhance students' life skills in the field of biology, and analyzes the challenges that may hinder its implementation. Using a Systematic Literature Network Analysis (SLNA), which combines Bibliometrics Analysis (BA) and Systematic Literature Review (SLR), this study analyzed articles from SCOPUS that met specific criteria. The findings reveal that PjBL is associated with e-learning and blended learning, and that the majority of articles on PjBL were published in 2020, particularly in the Journal of Microbiology & Biology Education. Additionally, this SLNA highlights the contributions of these articles to the development of various life skills in biology learning. By identifying key trends and insights from existing literature, this study sheds light on the potential of PjBL to enhance students' biology education and their ability to apply it in their daily lives.
Relationship between the attitudes of biology education students towards statistics with knowledge of data analysis
Authors: Fauzi Ahmad , Fatmawati Diani , Hali Ali Usman
Published: February 2023

Students' knowledge of data analysis determines the quality of the research they report but they tend to perceive courses on statistics or data analysis as challenging and unappealing. The present study aimed to investigate the correlation between biology education students' attitudes toward statistics and their proficiency in determining various data analytical techniques. This study involved biology education students from the Universitas Muhammadiyah Malang who had completed a course in statistics, research methods, and data analysis. The Survey of Attitudes Toward Statistics (SATS) and the Statistics Assessment of Graduate Students (SAGS) were used sequentially as instruments for collecting data on student attitudes toward statistics and data analysis competencies. The results revealed that while most students had positive attitudes toward statistics, they perceived the subject as challenging to learn. Additionally, the students demonstrated low levels of competency in data analysis. The aspects of cognitive competence and difficulty from SATS correlate significantly with their SAGS score. These results suggest that there is a need for a revision of the biology education curriculum to better equip students with the skills and knowledge to increase their data analysis competencies.
Oral Crizotinib induced severe esophageal ulcer with stenosis: a case report and literature review
Authors: Zhang Bingqiang , Wang Song , Zhang Binglan , Yadav Satish Chandra , Zhang Xia
Published: February 2023

Crizotinib is an oral [anaplastic lymphoma
kinase](https://en.wikipedia.org/wiki/Anaplastic_lymphoma_kinase)
and [c-ros oncogene
1](https://en.wikipedia.org/wiki/C-ros_oncogene_1) inhibitor, which
is approved by the Food and Drug Administration for the treatment of
metastatic non-small cell lung cancer (NSCLC). The 2011 Clinical trials
demonstrated excellent treatment response, survival, and few side
effects. We report a case of severe ulcerative oesophagitis with
stenosis that was not reported in the 2011 Clinical trials and earlier
studies.
Development of Multisensory Processing in Ferret Parietal Cortex.
Authors: Medina Alexandre , Foxworthy W. Alex , Keum Dongil , Meredith M. Alex
Published: February 2023

It is well known that the nervous system adjusts itself to its
environment during development. Although a great deal of effort has been
directed toward understanding the developmental processes of the
individual sensory systems (e.g., vision, hearing, etc.), only one major
study has examined the maturation of multisensory processing of cortical
neurons. Therefore, the present investigation sought to evaluate
multisensory development in a different cortical region and species.
Using multiple single-unit recordings in anesthetized ferrets (n=18) of
different ages (from postnatal day 80 through 300), we studied the
responses of neurons from the rostral posterior parietal area (PPr) to
presentations of visual, tactile and combined visual-tactile
stimulation. The results showed that multisensory neurons were
infrequent at the youngest ages (pre-pubertal) and progressively
increased through the later ages. Significant response changes that
result from multisensory stimulation (defined as multisensory
integration, MSI) were observed in post-pubertal adolescent animals and
the magnitude of these integrated responses also increased across this
age group. Furthermore, non-significant multisensory response changes
were progressively increased in adolescent animals. Collectively, at the
population level, MSI was observed to shift from primarily suppressive
levels in infants to increasingly higher levels in later stages. These
data indicate that, like the unisensory systems from which it is
derived, multisensory processing shows developmental changes the
specific time course of which may be regionally and species dependent.
Initiation of Continuous Glucose Monitoring Is Linked to Improved Glycemic Control and Fewer Clinical Events in Type 1 and Type 2 Diabetes in the Veterans Health Administration
Authors: Reaven Peter D. , Newell Michelle , Rivas Salvador , Zhou Xinkai , Norman Gregory J. , Zhou Jin J.
Published: February 2023

OBJECTIVE

To determine the benefit of starting continuous glucose monitoring (CGM) in adult-onset type 1 diabetes (T1D) and type 2 diabetes (T2D) with regard to longer-term glucose control and serious clinical events.

RESEARCH DESIGN AND METHODS

A retrospective observational cohort study within the Veterans Affairs Health Care System was used to compare glucose control and hypoglycemia- or hyperglycemia-related admission to an emergency room or hospital and all-cause hospitalization between propensity score overlap weighted initiators of CGM and nonusers over 12 months.

RESULTS

CGM users receiving insulin (n = 5,015 with T1D and n = 15,706 with T2D) and similar numbers of nonusers were identified from 1 January 2015 to 31 December 2020. Declines in HbA1c were significantly greater in CGM users with T1D (−0.26%; 95% CI −0.33, −0.19%) and T2D (−0.35%; 95% CI −0.40, −0.31%) than in nonusers at 12 months. Percentages of patients achieving HbA1c <8 and <9% after 12 months were greater in CGM users. In T1D, CGM initiation was associated with significantly reduced risk of hypoglycemia (hazard ratio [HR] 0.69; 95% CI 0.48, 0.98) and all-cause hospitalization (HR 0.75; 95% CI 0.63, 0.90). In patients with T2D, there was a reduction in risk of hyperglycemia in CGM users (HR 0.87; 95% CI 0.77, 0.99) and all-cause hospitalization (HR 0.89; 95% CI 0.83, 0.97). Several subgroups (based on baseline age, HbA1c, hypoglycemic risk, or follow-up CGM use) had even greater responses.

CONCLUSIONS

In a large national cohort, initiation of CGM was associated with sustained improvement in HbA1c in patients with later-onset T1D and patients with T2D using insulin. This was accompanied by a clear pattern of reduced risk of admission to an emergency room or hospital for hypoglycemia or hyperglycemia and of all-cause hospitalization.
Naevus lipomatosus cutaneous superficialis of Hoffmann-Zurhelle with angiokeratoma of Fordyce
Authors: Al-Mutairi N , Joshi A , Nour-Eldin O.
Published: February 2023

This article does not have an abstract.
Mengembangkan Kemampuan Self-Regulated Learning Bidang Metakognisi
Authors: Kristanto Andi , Pradana Hirnanda Dimas
Published: February 2023

Kemampuan self-regulated sangat penting untuk dimiliki oleh mahasiswa. Hal ini mencakup perilaku, karena individu mengatur tindakan mereka untuk membuat mereka tetap berfokus pada pencapaian tujuan. Self regulated learning diperlukan oleh mahasiswa untuk dapat menjadikan dirinya pribadi yang bertanggung jawab atas dirinya. Penelitian ini bertujuan untuk menganalisis kebutuhan di lapangan terkait pengembangan self regulated learning dalam metakognisi mahasiswa. Subjek penelitian ini melibatkan 100 mahasiswa dari program studi teknologi pendidikan. Penelitian deskriptif kualitatif ini dilakukan dengan metode survei. Pengumpulan data menggunakan kuesioner. Lembar kuesioner digunakan untuk mengumpulkan data tentang self regulated learning mahasiswa program studi teknologi pendidikan. Analisis data dilakukan secara deskriptif kualitatif dari data penelitian dilakukan. Berdasarkan temuan investigasi yang dilakukan, terlihat bahwa self regulated learning sangat dibutuhkan dalam pembelajaran di tingkat universitas. Mahasiswa membutuhkan pembelajaran yang bisa meningkatkan kemandirian belajar dalam diri  mereka serta bisa menjadi pribadi yang jauh lebih baik. Langkah selanjutnya yang diperlukan adalah mengembangkan pembelajaran berbasis self regulated learning untuk mahasiswa teknologi pendidikan.
Media Pembelajaran E-KOMED Topik Siklus Hidup Makhluk Hidup Kelas IV SD
Authors: Ni Luh Putu Ari Sintya Dewi  , Ni Wayan Rati  , Adrianus I Wayan Ilia Yuda Sukmana
Published: February 2023

Kurangnya pemanfaatan media pembelajaran elektronik untuk dapat digunakan belajar secara mandiri menyebabkan siswa kurang termotivasi dalam belajar. Hal ini berdampak pada rendahnya hasil penilaian tengah semester siswa. Tujuan dari penelitian ini yaitu untuk mengembangkan media pembelajaran E-KOMED (elektronik komik edukatif) topik siklus hidup makhluk hidup kelas IV SD. Jenis penelitian ini yaitu pengembangan. Model ADDIE menjadi patokan dalam tahap penelitian ini dikarenakan model ADDIE. Subjek uji coba penelitian ini adalah ahli materi, ahli media, ahli bahasa, guru praktisi, dan siswa kelas IV SD. Metode yang digunakan untuk mengumpulkan data yaitu kuesioner. Instrument yang digunakan untuk mengumpulkan data yaitu instrumen dengan rating scale skala 4. Teknik yang digunakan untuk menganalisis data yaitu analisis deskriptif kualitatif dan kuantitatif. Hasil penelitian yaitu skor rata-rata dari ahli materi, ahli bahasa, ahli media dan praktisi secara berturut-turut sebesar 3,96, 3,90, 3,62, dan 3,90. Perolehan uji coba perorangan dan kelompok kecil sebesar 3,58 dan 3,36. Secara keseluruhan validitas media pembelajaran E-KOMED memperoleh kualifikasi sangat baik. Disimpulkan bahwa media pembelajaran E-KOMED layak untuk dipergunakan pada pembelajaran di Sekolah dasar. Implikasi pembelajaran ini guru memperoleh referensi baru mengenai media pembelajaran serta siswa dapat lebih mudah memahami materi karena siswa mendapatkan pengalaman dengan membaca komik secara langsung dengan topik siklus hidup makhluk hidup.
Media Presentasi pada Mata Pelajaran IPA Siswa Kelas V SD
Authors: Eva Mayasari  , I Komang Sudarma  , Alexander Hamonangan Simamora
Published: February 2023

Guru kesulitan dalam berinovasi mengembangkan sebuah pembelajaran berbasis digital. Hal ini berdampak pada motivasi dan hasil belajar siswa yang rendah. Tujuan penelitian ini yaitu mengembangkan media persentasi pada mata pelajaran IPA untuk siswa kelas V SD. Jenis penelitian ini yaitu pengembangan dengan model ADDIE. Subjek penelitian ini yaitu 1 ahli mata pelajaran, 1 ahli media pembelajaran, dan 1 ahli desain pembelajaran. Subjek uji coba siswa berjumlah 32 siswa. Metode pengumpulan data yaitu wawancara, observasi, dan kuesioner. Instrument pengumpulan data yaitu kueioner. Teknik menganalisis data yaitu analisis deskriptif kualitatif dan kuantitatif. Hasil penelitian yaitu penilaian ahli isi pelajaran yaitu 95,8% (sangat baik). Hasil penilaian dari ahli media pembelajaran yaitu 95,8%  (sangat baik). Hasil penilaian dari ahli desain pembelajaran yaitu 5% (baik). Hasil uji coba perorangan yaitu 96,66% (sangat baik) dan uji coba kelompok kecil yaitu 98% (sangat baik). Disimpulkan bahwa media presentasi layak digunakan dalam pembelajaran. Media persentasi membantu siswa belajar IPA sehingga motivasi belajar menjadi meningkat.
Instrumen Tes Pengetahuan Technological Pedagogic Content Knowledge (Tpack) Untuk Calon Guru Sekolah Dasar
Authors: Ni Wayan Ayu Utari Sri Maharani  , Putu Nanci Riastini  , I Gede Marguna Yasa
Published: February 2023

Studi ini dilatarbelakangi oleh temuan di lapangan yang menyatakan mayoritas kajian mengarah kepada pengukuran persepsi penguasaan belum pada wawasan mengenai TPACK khususnya pada guru sekolah dasar. Tujuan kajian ini ialah menghasilkan instrumen pengetahuan TPACK pada calon guru sekolah dasar. Penelitian ini mempergunakan pemodelan pengembangan 4D yang meliputi define, design, develop serta disseminate. Metode dan penghimpunan data yang dipergunakan pada kajian ini yakni kuesioner serta rating scale. Subjek pada studi pengembangan ini ialah instrumen tes pengetahuan TPACK, sedangkan objeknya ialah kualitas instrumen seperti validitas isi, validitas butir, reliabilitas, daya beda, serta tingkat kesukaran. Teknik analisa data yang dipergunakan yaitu analisa deskriptif. Hasil penelitian yaitu yang diberikan oleh para ahli kriteria sangat tinggi sehingga valid. Hasil penilaian dari uji perorangan secara keseluruhan mendapatkan kategori sangat baik. Dapat disimpulkan bahwasanya instrumen tes pengetahuan TPACK layak dipergunakan. Instrumen yang dihasilkan bisa memotivasi calon guru sekolah dasar untuk lebih interaktif dengan perkembangan zaman sehingga bisa membangkitkan kecakapannya dalam mengembangkan wawasan pada aktivitas belajar.
Identity Construction in Company Persuasive Discourse
Authors: Wuryaningrum Rusdhianti , Muti'ah Arju
Published: February 2023

Constructing an identity is an important part of a company or business. This study aims to analyze information hierarchy text and reveal discourse cognition in constructing corporate identity. Both of these concepts are used to see and reveal the agent’s wishes and communications made in showing identity. The research data was obtained by documenting persuasive discourse on the nestlé and aqua-Danone websites in Indonesia. Research results direct our minds that there are two types of hierarchies built by the company: hierarchy text based on general truth and hierarchy text based on product identity. Cognition built-in discourse is generally the same. It is built through concrete language to show efforts to save the environment. The language tools used are mental imagery words, action words, and concrete language. From these two studies, it can be seen that corporate identity can be shown directly and indirectly and the target to be built is to save the environment.
Exploration of Student-Athletes’ Mental Toughness Due to Frequency of Synchronous Online Learning
Authors: Pambudi Aris Fajar , Setyawan Hendra , Rizkyanto Willy Ihsan , Gani Ismail , Antoni Muhammad Sigit
Published: February 2023

This study explores the decrease in mental toughness due to the frequency of seated synchronous online learning among BAPOMI DIY athletes. This study is a combined study of simultaneously embedded models, with quantitative methods as the primary method and qualitative methods as the secondary method. Fifty BAPOMI athletes from various sports statuses as students at DIY were recruited through purposive sampling with the consideration that they were implementing synchronous learning. This research also enrolled six coaches and trainers in BAPOMI DIY. Quantitative data was collected using a 1–5 scale questionnaire, and qualitative data using semi-structured interviews. Descriptive statistics analyze quantitative data, and qualitative data is analyzed by data reduction, data presentation, and conclusion. The results of the quantitative study show that the decrease in the mental strength of self-confidence of BAPOMI DIY athletes due to synchronous online learning is included in the high category. In the decline of mental toughness, fatigue is included in the moderate category. Decreased mental toughness is included in the high category. Decreased mental endurance motivation (training/competition) is included in the high category. Decreasing mental strength symptoms of depression are included in the high category. The results of this quantitative data are also in line with the statements of coaches and parents of students who stated that: during online learning, athletes are tired because there are more tasks, the interest in training is reduced compared to offline learning, less focus and less. from enthusiasm, tiredness from sitting in front of the laptop, and reduced concentration due to many lecture assignments. Athletes feel bored, are often late for practice, sometimes get permission to do college assignments, come, often ask for permission, decrease training motivation, decrease fitness, and don't look fit. It can be concluded that synchronous online learning takes too long and sits a lot that is not matched with regular physical activity among athletes, which can cause a decrease in mental toughness from various aspects at a high level. However, there is one aspect that is included in the level category low but still conditional. The role of the coach is becoming more and more critical because they can diligently control the physical and psychological development of the athlete.
Aktivitas senyawa antioksidan Scurrula ferruginea (Jack) Dans dengan inang Kakao (Theobroma cacao)
Authors: Pratama Novia Mayang , Salni Salni , Marisa Hanifa
Published: February 2023

Antioksidan adalah senyawa yang mampu menghambat radikal bebas yang dapat menyebabkan penyakit dalam tubuh dan dapat diisolasi dari tanaman. Benalu merupakan salah satu tanaman yang mengandung flavonoid, tanin, terpenoid dan alkaloid. Scurrula ferruginea (Jack)  Dans dengan inang kakao (Theobroma cacao) diasumsikan memiliki senyawa antioksidan. Penelitian ini bertujuan untuk menentukan aktivitas antioksidan fraksi n-heksana, etil asetat dan metanol dari daun Scurrula ferruginea, untuk menentukan kelompok senyawa murni yang memiliki antioksidan dan untuk menentukan nilai IC50 dari senyawa antioksidan murni. Metode penelitian dimulai dengan persiapan sampel, ekstraksi, fraksinasi cair-cair, isolasi senyawa dengan kromatografi cair vakum dan kromatografi kolom dan uji aktivitas antioksidan menggunakan metode DPPH. Penelitian ini menunjukkan bahwa fraksi etil asetat memiliki aktivitas kuat dan diikuti oleh fraksi n-heksan, sedangkan fraksi metanol memiliki aktivitas lemah. Isolat antioksidan aktif dalam fraksi n-heksan adalah senyawa H1 dan H2.1 dengan senyawa terpenoid. Sedangkan dalam fraksi etil asetat menghasilkan satu senyawa aktif, E1.1. dengan kelas senyawa flavonoid. Hasil penentuan aktivitas antioksidan dengan metode DPPH menunjukkan nilai IC50 pada senyawa H1, H2.1 dan E1.1. masing-masing 127,46; 129.28 dan 92.3 ppm. Senyawa H1 dan H2.1. memiliki aktivitas antioksidan sedang dan senyawa E1.1 memiliki aktivitas antioksidan yang kuat.
Cefiksym – doustna cefalosporyna III generacji dla dzieci
Authors: Sybilski Adam J. , Kudan Małgorzata
Published: February 2023

Cefiksym to półsyntetyczny antybiotyk β-laktamowy, cefalosporyna III generacji do stosowania doustnego zarówno u dzieci (rejestracja od 6. m.ż.), jak i u dorosłych. Wykazuje on silne działanie bakteriobójcze w mechanizmie hamowania biosyntezy ściany komórkowej bakterii. Spektrum działania to: Streptococcus pyogenes, Haemophilus influenzae, Moraxella catarrhalis, Proteus mirabilis. Wskazaniami klinicznymi do zastosowania cefiksymu u dzieci są: pozaszpitalne zapalenie płuc, zapalenie dolnych dróg moczowych, odmiedniczkowe zapalenie nerek, zapalenie ucha środkowego, zapalenie zatok, zapalenie gardła. Dane z badań klinicznych jednoznacznie wskazują na wysoką skuteczność antybiotyku u dzieci i młodzieży, jednocześnie wykazując duże bezpieczeństwo i rzadkie działania niepożądane (głównie żołądkowo-jelitowe). Właściwości farmakokinetyczne i farmakodynamiczne sprawiają, że antybiotyk może być podawany raz na dobę, niezależnie od posiłków.

W artykule opisano trzy typowe przypadki zastosowania cefiksymu u dzieci. Przedstawiono dzieci leczone z powodu odmiedniczkowego zapalenia dróg moczowych, pozaszpitalnego zapalenia płuc i ostrego zapalenia ucha środkowego. Skuteczność, bezpieczeństwo, biodostępność, dobry smak oraz łatwy schemat dawkowania sprawiają, że cefiksym jest właściwą opcją antybiotykoterapii u dzieci.
Arypiprazol – teoria i praktyka
Authors: Szulc Agata
Published: February 2023

Arypiprazol jest jednym z leków przeciwpsychotycznych II generacji, inaczej – atypowych, znanym od kilkunastu lat. Ma unikalny profil receptorowy względem pozostałych leków przeciwpsychotycznych, co znajduje odzwierciedlenie w jego efekcie terapeutycznym i profilu tolerancji. Działa jak antagonista w sytuacji nadmiaru dopaminy, natomiast przy jej niskich stężeniach eksponuje właściwości agonistyczne. Jak pokazują liczne badania, w zależności od dawki arypiprazol jest skuteczny w leczeniu schizofrenii i choroby afektywnej dwubiegunowej zarówno w okresie zaostrzenia, jak i w terapii podtrzymującej. Jest też lekiem często stosowanym w politerapii. Niniejszy artykuł dostarcza przeglądu informacji na temat zastosowania arypiprazolu w monoterapii, która powinna stać się rutynową praktyką w leczeniu zaburzeń psychicznych.