bluuebunny/crossref_metadata_2025 huggingface dataset:
Argumentar en la universidad: un proceso más allá del producto textual
Authors:   Universidad Nacional Autónoma de México, López Vázquez Julieta Arisbe , García Velázquez Luis Miguel ,   Universidad Nacional Autónoma de México
Published: October 2022

El objetivo es determinar cuáles son las habilidades textuales y argumentativas que los estudiantes deben desarrollar para alcanzar el éxito académico y profesional, y buscar una metodología que permita su desarrollo. Así, la pregunta es ¿cómo pueden contribuir las instituciones de educación superior a desarrollar tales habilidades? Ello se responde a través de un proyecto académico sostenido a lo largo de tres años, que permite medir los progresos en estudiantes que cursan alguna de las licenciaturas de la Escuela Nacional de Estudios Superiores, unidad Morelia, de la Universidad Nacional Autónoma de México. Los resultados muestran que fortalecer el proceso argumentativo lleva, en la mayoría de los casos, a un producto en el que mejoran las condiciones de textualidad: coherencia, cohesión, informatividad, intertextualidad. Es pertinente el desarrollo de investigaciones adicionales en distintos niveles educativos que posibilitaran obtener resultados semejantes y, al mismo tiempo, identificar otros factores que contribuyan a la producción textual.
Generalization of the issues with implementing inclusive education in Ukraine empirical findings from sociological research experience
Authors: Hrabovets Iryna , Kalashnikova Liudmyla , Chernous Liudmyla
Published: October 2022

The focus of the paper is on the ongoing issues with the inclusion approach in the educational system. The authors make an effort to study legal documents governing inclusive education, the accessibility of medical and educational facilities, and the willingness of the teaching profession to engage with students who have special educational requirements. the empirical foundation created by a variety of empirical data gathered through traditional document analysis, parent and teacher interviews, and other means. The examination of the research's findings enables us to draw the conclusion that informants are well aware of the challenges facing inclusive education in the present. They are linked to the majority of school buildings' lack of architectural accessibility, teachers' inadequate professional preparation, experience interacting with kids who have various types and degrees of diseases, and the society's inadequate level of readiness to understand the concept of integration.
Supervision as a form of inclusive education retraining and school community professional advancement
Authors: Bondar Kateryna , Shestopalova Olena
Published: October 2022

Using the example of Kryvyi Rih, we present the supervision model used to promote the education reform in Ukraine and the retraining of the school's major players. Through a sociopolitical and educational description of the current situation in Kryvyi Rih, empirical study has introduced a model of retraining. Due to this, 124 key stakeholders from 20 inclusive schools underwent testing to help plan the implementation of the monitoring model (teachers, tutors, staff, psychologists and parents from 7 districts of Kryvyi Rih were invited to participate). In this study, we provide an alternative strategy for interagency supervisory groups and communication, with an emphasis on the model supervision retraining of inclusive education specialists. Four stages make up the supervision process: case report, exchange, conceptualization, and summary. In the paper, we suggest a modification of an unstructured interview by a specialist who specifies the context of training supervision in order to facilitate successful work. The psycho-educational support team in inclusive education was able to propose the supervision program thanks to the analysis of the organizational, methodological, and information retraining system and the execution of the pilot project of supervisory groups: I. Providing team members with the necessary training to work with the objectives of each child development plan; II. Using case preparation tools; III. Analyzing environmental elements; and IV. Managing team support.
An Analysis of Cancer Stem Cells’ Effectiveness in Curing Tumor and Possible Therapies
Authors: Huang Zibin
Published: October 2022

This review focuses on the role of cancer stem cells in tumor development and summarizes multiple therapeutic approaches based on them. Cancer research has been significant in medical research as it is increasingly recognised as a worldwide public health concern. Although modern medical treatment can be done utilizing chemotherapy or radiotherapy, tumors’ high mortality and recurrence rate remain a critical issue. However, in recent years, based on a large number of studies on cancer, scientists have put forward the theory of cancer stem cells, aiming to provide prospective treatment theories and methods for cancer therapies. These innovative treatments have brought hope to a complete cure for cancer. This paper first reviews the current status of cancer development, the hot theory of cancer stem cells, and the role of cancer stem cells in curing cancer. Then, three popular cancer stem cell treatments are reviewed, briefly discussed, and analyzed. Finally, the prospect of a treatment system is examined based on cancer stem cells.
АДМІНІСТРАТИВНА ВІДПОВІДАЛЬНІСТЬ ЯК ЕЛЕМЕНТ СЛУЖБОВО-ТРУДОВИХ ВІДНОСИН КОМАНДУВАЧА НАЦІОНАЛЬНОЇ ГВАРДІЇ УКРАЇНИ
Authors: Назимко О.В. , Пискун О.В.
Published: October 2022

У статті розкрито особливості адміністративної відповідальності в діяльності командувача Національної гвардії України. Встановлено, що адміністративна відповідальність виступає у якості комплексного правового механізму реагування держави на різноманітні прояви адміністративної про-типравної поведінки. Зроблено висновок про тісний зв'язок адміністративної та дисциплінарної відпові-дальності військовослужбовців НГУ, на підставі порівняльно-правового аналізу статті 15 КУпАП та Дисциплінарного статуту ЗС України. Визначено поняття грубого дисциплінарного проступку, як умис-ної дії або бездіяльності військовослужбовця, вчиненого всупереч принципам і завданням Збройних Сил України та інших військових формувань із правоохоронними функціями, наслідком якої стало заподіяння істотної шкоди особі, суспільству або державі, а рівно посягання на організацію управління Національ-ної гвардії України.Запропоновано доповнити Порядок проведення службових розслідувань у Національній гвардії Ук-раїни кваліфікуючими ознаками грубого дисциплінарного проступку, вчиненого військовослужбовцем, до числа яких мають бути віднесені: можливість застосування до правопорушника двох і більше видів юридичної відповідальності; вчинення дисциплінарного проступку керівником органу військового управ-ління; вчинення дисциплінарного проступку під час несення служби в наряді; вчинення дисциплінарного проступку двома і більше військовослужбовцями; дисциплінарний проступок, пов'язаний із неправомір-ним застосуванням військовослужбовцем НГУ фізичної сили, спеціальних засобів або вогнепальної зброї.

Ключові слова: адміністративна відповідальність, Національна гвардія України, адміністратив-не правопорушення, адміністративні стягнення, юридична відповідальність, адміністративно-правові норми, дисциплінарна відповідальність.
Iontoforese e fonoforese no tratamento da dor lombar: um ensaio clínico comparativo
Authors: Azevedo Deyse Corrêa de , Otto Douglas Maquart , Macagnan Fabri­cio Edler , Figueiredo Vitângela Freitas
Published: October 2022

Introdução: De etiologia multifatorial, a lombalgia não específica é caracterizada por dor persistência (> 3 meses) e perda gradual da função/funcionalidade. Por afetar ambos os sexos e ser altamente prevalente na população trabalhadora, constitui importante causa de absenteísmo. Objetivo: Comparar a evolução clínica de pacientes diagnosticados com lombalgia inespecífica tratados com sulfato de magnésio (MgSO4) associado a iontoforese (I) e MgSO4 associado à fonoforese (F). Métodos: Neste ensaio clínico, a sensação de dor foi avaliada através da escala visual analógica (EVA) e questionário de dor de McGill. O questionário Roland-Morris Brasil de Incapacidade Lombar foi o instrumento utilizado para avaliar a funcionalidade. A amostra foi composta por 24 pacientes divididos sequencialmente em dois grupos (I: 11 e F: 13). A evolução clínica dos pacientes (diferença pré-pós) foi comparada ao final das intervenções. Resultados: Houve redução significativa na sensação de dor (I: -55%, p = 0,001; F: -27%, p = 0,08) e melhora na funcionalidade em ambos os grupos (I: -54%, p = 0,001; F: -55%, p = 0,02), mas não foi observada diferença significativa entre os grupos. Os resultados agrupados em metanálise para avaliar os desfechos de flexibilidade, funcionalidade e força também demonstram similaridade entre as intervenções. Conclusão: Dadas as condições clínicas estudadas, ambas técnicas podem alcançar resultados similares. Embora não haja dados que apoiem a recomendação de uma técnica em substituição a outra, novos estudos podem aumentar o tamanho amostral e esclarecer melhor algumas tendências de superioridade observadas no tratamento álgico com MgSO4 associado à iontoforese.
THE IMPACT OF LIBERAL FEMINISM MOVEMENT IN A PROMPTBOOK HE AND SHE
Authors: Tambunan Sunarti Desrieny , Safitri Ratna
Published: October 2022

Liberal feminism is a universal approach in which women and men are equal in basic rights such as education, work, financial security, voting and many more. This research aims to find out the impact of emancipation movement in a promptbook entitled He and She play using Tong and Botts’ theory. The method used in this research is a descriptive qualitative method. The result shows that most of the characters in the promptbook accept the movement, except Keith, Ruth’s boyfriend, who thinks women in his era act like superiors because of the movement. He does not accept it by showing that his girlfriend cannot have a higher position than him. She cannot work and just stay at home after they get married. At the end, he will only cut his girlfriend’s half-life. This movement can give good or bad impact for the society or surroundings, especially the men. For those who are old-fashioned thinking, this can be a threat.
Unit Link Application Quality Analysis Using ISO 25010 . Method (Case Study of PT Asuransi Jiwasraya Persero)
Authors: Manu Ulfa Tunisa , Noviana Rina
Published: October 2022

Abstract : PT Asuransi Jiwasraya Persero is a state-owned insurance company that is the largest local insurance company in Indonesia. PT Asuransi Jiwasraya has many products for individuals and groups. Jiwasraya's product management uses the Unit Link application, which is a web-based application that is used to facilitate the management of product transactions at Jiwasraya. Research on the analysis of Unit Link application quality aims to determine the quality of the application, using ISO 25010 which is a standard for software with eight characteristics, including functional suitability, performance efficiency, compatibility, usability, portability, and security. Determination of weights using the Analytical Hierarchy Process (AHP) method with the testing methods used are blackbox testing, questionnaires, observation and stress testing. The unit link application test got a score of 4.196 with a good category and the research results can help to determine the quality of the Unit Link application.

Keywords: ISO 25010, Quality, Application, User Satisfaction, Unit Link
Penerapan Learning Management System Berbabis Web dan Aplikasi di Language Center Bina Darma Palembang
Authors: Khudri Akhmad
Published: October 2022

Pandemi COVID-19 yang sedang dirasakan oleh sebagian besar masyarakat dunia, membawa dampak yang luar biasa besar. Termasuk di ranah pendidikan, dimana sedang terjadi pergeseran pola belajar dan mengajar yang sebelumnya lebih kepada pertemuan tatap muka antara pengajar dan pelajar, kini beralih kepada pertemuan secara daring. Hal ini membuat para pengajar yang ada di lingkungan Language Center Bina Darma Palembang harus lebih kreatif dalam menyampaikan materi yang diajarkan, agar lebih menarik minat dari para pelajar serta mempermudahkan mereka dalam menyerap ilmu yang diajarkan oleh para pengajar dengan maksimal. Website dan aplikasi kini menjadi primadona baru untuk media penyampaian materi kepada para pelajar. Dan dengan menggunakan website serta aplikasi yang bersifat learning management system (LMS), salah satu masalah dalam proses belajar dan mengajar tersebut dapat di selesaikan dengan baik.
Erratum
Authors: Shaw David
Published: October 2022

Shaw DM, Henderson L, van den Berg M. Cognitive, sleep, and autonomic responses to induction of a ketogenic diet in military personnel: a pilot study. Aerosp Med Hum Perform. 2022; 93(6):507516.In the article by Shaw et al., the publishers neglected to include the
author corrections to the manuscript. The corrected manuscript is available through the online journal on Ingenta at: https://www.ingentaconnect.com/contentone/asma/amhp/2022/00000093/00000006/art00007.Those
corrections that affect the study directly are published in this erratum. We sincerely apologize for this error and the inconvenience it has caused.
Propuesta de estandarización, conexión e innovación para procesos tercerizados
Authors: Betancur Bustamante Diana Lucía , Cardona Álvarez Lina María
Published: October 2022

En el contexto de las prácticas estudiantiles del Politécnico Colombiano Jaime Isaza Cadavid surge el Comité Universidad -Empresa –Estado (CUEE) como apoyo al sector terciario posibilitando la sinergia entre universidad, empresa y Estado que favorece la articulación de los estudiantes con el entorno laboral. Una de las metodologías del CUEE es la creación de retos que apoyen la resolución de problemas que beneficien los procesos educativos y empresariales. El objetivo de este artículo es presentar una propuesta, desde esta metodología, que reduzca la brecha del proceso logístico y de producción tercerizado por la empresa TOOL BE, la cual se dedica al acompañamiento a los padres y cuidadores para la estimulación temprana de niños. El resultado más importante del ejercicio fue el diseño de la estrategia de solución integral denominada: “Estandarización, conexión e innovación: menos brechas en la tercerización” para dicha empresa.
In the context of student internships at the Politécnico Colombiano Jaime Isaza Cadavid, the University-Company-State Committee (CUEE) arises as a support to the tertiary sector, enabling the synergy between university, company, and State that favors the articulation of students with the work environment. One of the CUEE methodologies is the creation of challenges that support the resolution of problems that benefit the educational and business processes. The objective of this article is to present a proposal, from this methodology, which reduces the gap in the logistic and production process outsourced by the company TOOL BE, which is dedicated to the accompaniment of parents and caregivers for the early stimulation of children. The most important result of the exercise was the design of an integrated solution strategy called: "Standardization, connection, and innovation: fewer gaps in outsourcing" for this company.
Eficiencia del carbón Guajiro y Quitosano en la remoción de parámetros fisicoquímicos en aguas residuales domésticas
Authors: Torres-Cervera Karina Paola , Macea-Triana Marlon David , Rojas-Sanmiguel Linda Lucía , Rodriguez Yim James , Romero-Benjumea Luis Alberto , Cahuana Aleana , Martínez Maestre Melisa
Published: October 2022

Se evaluó y comparó la eficiencia de dos coagulantes Naturales: Cardón Guajiro (Stenocereus Griseus) y Quitosano para tratamiento de agua residual doméstica. El Cardón se extrajo por un proceso de secado, molienda, tamizado y extracción con metanol anhidro. El Quitosano se consiguió en forma de escamas. Se realizaron pruebas de jarras para determinar rangos y dosis óptimas y analizar los parámetros de estudio a medida que se iban aplicando dichos coagulantes. Con el Cardón se realizaron dos pruebas con concentraciones del 5% y 10%, con el Quitosano se realizaron pruebas a una concentración del 1%. Las dosis de Cardón estuvieron entre 10 y 100 PPM en intervalos de 10, las dosis de Quitosano fueron de 50 a 500 PPM en intervalos de 50. El Cardón a concentración del 5% generó excelentes resultados en los parámetros de estudio. El Quitosano mostró porcentajes de remoción mejores que el Cardón Guajiro.
Análisis de la incidencia geotécnica para la construcción de un distrito de riego en el departamento de Atlántico – Colombia
Authors: Vanegas-Padilla Angelica Patricia , Ortega-Sinning Eberto Rafael
Published: October 2022

En la presente investigación realizó el análisis de la incidencia geotécnica de los suelos presentes en el municipio de Ponedera, localizado en el departamento del Atlántico para la construcción de un distrito de riego mediante la toma de muestras a través de apiques manuales junto con ensayos de penetración estándar (SPT). Esta información fue procesada en una base de datos para su correcta manipulación y análisis. Como producto de esta investigación se obtuvo el tipo de suelo los cuales fueron en su mayoría arcillas y limos inorgánicos (CL y ML) y en poca medida arenas limosas y arcillosa (SM y SC), también se realizaron mapas en (SIG) de zonificación del tipo de suelo y capacidades admisibles de dichos suelos. No se encontró nivel freático en el área de suelo investigada. Este estudio por el tipo de información obtenida siguiendo los lineamientos del Reglamento Colombiano Sismo Resistente (NSR-10) y el RAS, contiene información de utilidad para futuros estudios. Se concluye que el suelo explorado puede soportar capacidades de carga a aproximadamente 3,0 metros de profundidad de 31,8 Ton/m2 en suelos arcillosos y limosos.

The analysis of the geotechnical incidence of the soils present in the municipality of Ponedera, (Atlántico, Colombia) for the construction of an irrigation district was carried out by taking samples through manual piping and standard penetration tests (SPT). This information was processed in a database for analysis. The type of soil was obtained, which was mostly classified as inorganic clays and silts (CL and ML) and to a lesser extent silty and clayey sands (SM and SC), maps were made in (GIS) of soil type zoning and allowable capacities. No water table was found in the investigated soil area. Following the guidelines of the Colombian Earthquake Resistant Regulation (NSR-10) and the RAS, the usefulness for future studies is concluded. Finally, the soil explored can support load capacities at a depth of 3.0 meters of 31.8 Ton/m2.
Efecto del ejercicio físico sobre la aptitud física y estrés en pacientes por consumo de sustancias psicoactivas
Authors: Ramirez-Herrera Sandra Milena , Arenas-Granada Jaime Alberto , Giraldo-Duque Edwin
Published: October 2022

El ejercicio físico (EF) regular tiene beneficios en la salud; además, es recomendado como estrategia útil en el tratamiento por consumo de sustancias psicoactivas (SPA). Se estudiaron diferencias y efecto del EF sobre la aptitud física y estrés en sujetos drogodependientes. El diseño pre-experimental pretest-postest con un solo grupo conformado por (n=4, Medad=22.0, DE=5.3), evaluados y elegibles según el autoreporte PAR-Q & YOU y el inventario IDARE. Los resultados mostraron que la resistencia muscular de miembros superiores e inferiores obtuvieron diferencias significativas (p< 0.03, y 0.00), aunque el tamaño del efecto no evidenció valores positivos (d = -1.79 y -6.00); la capacidad aeróbica, resistencia muscular abdominal y flexibilidad no reportaron significación estadística y el tamaño del efecto fue negativo; el estrés mostró diferencias significativas. Los hallazgos revelan que el EF puede generar cambios positivos en algunos componentes de la aptitud física en los pacientes. Se debe seguir investigando esta línea de trabajo.
Regular physical activity (PE) has positive health effects, and it is also suggested as a helpful tactic in the management of psychoactive substance use (PAS). Study individuals who were drug addicted looked at differences and the impact of PE on stress and physical fitness. The pre-experimental pretest-posttest design included a single group of (n=4, Mage=22.0, SD=5.3) individuals who were evaluated and eligible based on the PAR-Q & YOU self-report and the IDARE inventory. The results showed that the muscular resistance of the upper and lower limbs had significant differences (p 0.03, and 0.00), but the effect size was negative (d = -1.79 and -6.00); aerobic capacity, abdominal muscular resistance, and flexibility did not show statistical significance, and the effect size was negative; stress showed significant differences. The findings show that PE can improve some aspects of physical fitness in patients. This area of research should be looked into further.
Cybersecurity Policy, Punctuated Equilibrium Theory, and the Biden Administration
Authors: Shively Jacob
Published: October 2022

This paper extends research on national cybersecurity policy by testing whether punctuated equilibrium theory (PET) effectively explains the Biden administration’s early positions on cyber and national security. Debate persists regarding whether and to what degree new administrations are able to chart new directions in major policy areas. Cybersecurity presents a particularly pressing challenge. Observers might expect a high degree of flexibility as strategic concepts, technical capabilities, and organization structures continue to evolve. Further, in the United States, transitions between presidential administrations and political parties represent major putative policy change. An earlier study found that, as predicted in PET, the Trump administration’s cybersecurity remained relatively constrained within existing policy frameworks. This paper extends that work by testing whether the Biden national cybersecurity policy conforms to predictions made by punctuated equilibrium theory. It evaluates the origins and content of the Biden administration’s major cybersecurity policies between early 2021 and mid-2022.
Large and Honest COVID-19 Relief: A Subnational Qualitative Comparative Approach with Evidence from Colombia
Authors: Prieto Juan Diego
Published: October 2022

Subnational governments played a major role addressing the socioeconomic toll of COVID-19. Still, we know little about why some (but not all) adopted generous social assistance measures, and why some of their interventions were more programmatic than others. Based on in-depth case studies of 23 Colombian cities, this article characterizes governments’ aid measures and employs fsQCA to explain differences. I find that no single factor is necessary or sufficient to produce broad or programmatic relief. Various combinations of structural factors and incentives for mayors’ political action are conducive to both outcomes. Electoral competitiveness and mobilization pushed mayors in wealthier, institutionally stronger cities to provide more aid, while opposition mayors delivered significant relief with more limited resources. Structural factors appear especially important for aid to be programmatic (with one exception). The findings call for a less static understanding of state capacity in the study of social policy and distributive politics.
Evaluating the usage of Dynamic Programming in Stereo Vision Algorithm Optimization
Authors: Umasudhan Mrinall
Published: October 2022

In modern research, the most studied step of stereo vision algorithms is the process of pixel correspondence, better known as stereo matching. As of now, researchers are attempting to integrate optimization techniques with stereo matching to improve stereo system performance. This paper seeks to provide an in-depth explanation of the stereo vision process in general and find value in the application of optimization techniques to stereo-matching algorithms. To analyze and implement a sound stereo vision algorithm as well as an optimized matching algorithm, scholarly sources involving stereo vision and optimization techniques were studied. After implementing a standard stereo-matching algorithm and an algorithm that involves a famous optimization technique known as Dynamic Programming, I found that there was a significant increase in both accuracy and efficiency in the depth estimates provided by the algorithm.
BOOK REVIEW: RICCARDI A. CHARISMATIC ITALY. BRESCIA: ED. MORCELLIANA, 2021.—245 P
Authors: Bakhmatova M. N.
Published: October 2022

Книга Андреа Риккарди (Риккарди А. Харизматическая Италия. Брешиа: изд. Морчеллиана, 2021 – 245 с.) представляет собой первую в историографии попытку дать общую картину харизматических проявлений итальянского католицизма последних двух столетий, которые отличаются большим разнообразием и многогранностью. С одной стороны, речь идет о традиционных формах народной религиозности, — санктуариях, девоциональных и паломнических практиках, почитании священных мест, изображений и т. д. С другой, — о харизматических личностях, основавших движения и ассоциации, ставшие местом притяжения тысяч католиков, которые не находили применения своему религиозному рвению в рамках официальной церкви. К харизматическим личностям относились и утонченные интеллектуалы, вступавшие иногда в противоречия с доктринальной линией РКЦ и претерпевавшие в связи с этим гонения. Харизматическая Италия — это сложная и разнообразная галактика, к которой институциональная Церковь присматривалась с интересом и беспокойством. Автор, ведя читателя по скрытым закоулкам итальянской религиозности, привлек внимание к теме, до сих пор не получившей своего исчерпывающего освещения. Выхватывая из историографического небытия то одно, то другое явление, А. Риккарди как бы наметил исследовательский маршрут, осилить который представит не одному поколению историков и антропологов.
Andrea Riccardi’s book is the first attempt to give an overview of the very diverse charismatic manifestations of Italian Catholicism in the last two centuries. On the one hand, these are traditional forms of popular religiosity — sanctuaries, devotional and pilgrimage practices, veneration of sacred places and icons, etc. On the other hand, these are charismatic personalities who founded movements and associations that attracted thousands of Catholics who did not manage to fit their religious zeal within the official church. The charismatic personalities also included sophisticated intellectuals who sometimes came into conflict with the doctrinal line of the RCC and thus suffered persecution. Charismatic Italy is a complex and diverse galaxy eyed by the institutional Church with interest and concern. The author guides the reader through the hidden corners of Italian religiosity and draws attention to a topic that has not yet been covered exhaustively. Snatching one or another phenomenon out of historiographical non‑existence, A. Riccardi outlined a research route, which is yet to be explored by more than one generation of historians and anthropologists.
Climate change and allergic diseases: An overview
Authors: Singh A. B. , Kumar Pawan
Published: October 2022

Climate change has been regarded as a threat to the human species on the earth. Greenhouse gasses are leading to increased temperatures on Earth besides impacting the humanity. These atmospheric conditions have shown to alter the release pattern of pollens and can change the timing and magnitude of pollen release with flowering plants. As pollen is responsible for respiratory allergies in humans, so climate change can adversely affect human health in susceptible individuals. In this review, we highlight the association between climate change, increased prevalence and severity of asthma, and related allergic diseases. Increased air pollution can alter the production of local and regional pollen. This altered pattern depends on bioclimatic parameters. As simulated with a pollen-release model and future bioclimatic data, warmer temperatures lead to an increased pollen count in some specific locations and for longer periods. Thus, anticipation of a future allergic disease burden can help public health agencies in planning to develop strategies in mitigating the unprecedented health challenges expected in future years.
On the mathematical modeling of schistosomiasis transmission dynamics with heterogeneous intermediate host
Authors: Madubueze Chinwendu E. , Chazuka Z. , Onwubuya I. O. , Fatmawati F. , Chukwu C. W.
Published: October 2022

Schistosomiasis is a neglected disease affecting almost every region of the world, with its endemicity mainly experience in sub-Saharan Africa. It remains difficult to eradicate due to heterogeneity associated with its transmission mode. A mathematical model of Schistosomiasis integrating heterogeneous host transmission pathways is thus formulated and analyzed to investigate the impact of the disease in the human population. Mathematical analyses are presented, including establishing the existence and uniqueness of solutions, computation of the model equilibria, and the basic reproduction number (R0). Stability analyses of the model equilibrium states show that disease-free and endemic equilibrium points are locally and globally asymptotically stable whenever R0 < 1 and R0>1, respectively. Additionally, bifurcation analysis is carried out to establish the existence of a forward bifurcation around R0 = 1. Using Latin-hypercube sampling, global sensitivity analysis was performed to examine and investigate the most significant model parameters in R0 which drives the infection. The sensitivity analysis result indicates that the snail's natural death rate, cercariae, and miracidia decay rates are the most influential parameters. Furthermore, numerical simulations of the model were done to show time series plots, phase portraits, and 3-D representations of the model and also to visualize the impact of the most sensitive parameters on the disease dynamics. Our numerical findings suggest that reducing the snail population will directly reduce Schistosomiasis transmission within the human population and thus lead to its eradication.
Death at the interface: Nanotechnology’s challenging frontier against microbial surface colonization
Authors: Kaur Kiran Deep , Habimana Olivier
Published: October 2022

The emergence of antimicrobial-resistant bacterial strains has led to novel approaches for combating bacterial infections and surface contamination. More specifically, efforts in combining nanotechnology and biomimetics have led to the development of next-generation antimicrobial/antifouling nanomaterials. While nature-inspired nanoscale topographies are known for minimizing bacterial attachment through surface energy and physicochemical features, few studies have investigated the combined inhibitory effects of such features in combination with chemical alterations of these surfaces. Studies describing surface alterations, such as quaternary ammonium compounds (QACs), have also gained attention due to their broad spectrum of inhibitory activity against bacterial cells. Similarly, antimicrobial peptides (AMPs) have exhibited their capacity to reduce bacterial viability. To maximize the functionality of modified surfaces, the integration of patterned surfaces and functionalized exteriors, achieved through physical and chemical surface alterations, have recently been explored as viable alternatives. Nonetheless, these modifications are prone to challenges that can reduce their efficacy considerably in the long term. Their effectiveness against a wider array of microbial cells is still a subject of investigation. This review article will explore and discuss the emerging trends in biomimetics and other antimicrobials while raising possible concerns about their limitations and discussing future implications regarding their potential combined applications.
A risk score model of contrast-induced acute kidney injury in patients with emergency percutaneous coronary interventions
Authors: Yuan Ying , Qiu Hong , Hu Xiaoying , Zhang Jun , Wu Yuan , Qiao Shubin , Yang Yuejin , Gao Runlin
Published: October 2022

Background

The previously built score models of contrast-induced acute kidney injury (CI-AKI) were principally founded on selective percutaneous coronary intervention (PCI) cases. Our study was to form a risk score model of CI-AKI and make a temporal validation in a population who underwent emergency PCIs.

Methods

We included patients who underwent emergency PCIs from 2013 to 2018 and divided them into the derivation and validation cohorts. Logistic regression analysis was harnessed to create the risk model. In this research, we defined CI-AKI as an increase in serum creatinine (SCr) ≥0.5 mg/dL (44.2 μmol/L) above baseline within seven days following exposure to contrast medium.

Results

A total of 3564 patients who underwent emergency PCIs were enrolled and divided into the derivation (2376 cases) and validation cohorts (1188 cases), with CI-AKI incidence of 6.61 and 5.39%, respectively. By logistic analysis, the CI-AKI risk score model was constituted by 8 variables: female (1 point), history of transient ischemic attack (TIA)/stroke (1 point), left ventricular ejection fraction (LVEF) classification (1 point per class), big endothelin-1 (ET-1) classification (1 point per class), estimated glomerular filtration rate (eGFR) classification (1 point per class), intra-aortic balloon pump (IABP) application (1 point), left anterior descending (LAD) stented (1 point), and administration of diuretic (2 points). The patients could be further divided into three groups: low-risk, moderate-risk, and high-risk groups, in accordance with the risk scores of 3–6, 7–10, and ≥11 points, and to the CI-AKI rates of 1.4, 11.9, and 42.6%. The CI-AKI risk score model performed well in discrimination (C statistic = 0.787, 95% CI: 0.731–0.844) and calibration ability, and showed a superior clinical utility.

Conclusion

We developed a simple CI-AKI risk score model which performs well as a tool for CI-AKI prediction in patients who underwent emergency PCIs.
Vitamin D and adrenal gland: Myth or reality? A systematic review
Authors: Al Refaie Antonella , Baldassini Leonardo , De Vita Michela , Gonnelli Stefano , Caffarelli Carla
Published: October 2022

In recent years, vitamin D has become the protagonist in many studies. From cardiology to oncology the spotlight was on this vitamin. While in the past it was considered for its important role in phospho-calcium metabolism and skeletal disorders; today by studying it better, thousands of scenarios and facets have opened up on this vitamin which is actually a hormone in all respects. There are authoritative studies that demonstrate its activity in vitro and in vivo on: carcinogenesis, inflammation, autoimmunity and endocrinopathies. Its role has been studied in type 1 and type 2 diabetes mellitus, in Hashimoto or Graves’ thyroiditis and even in adrenal gland diseases. In fact, there are several studies that demonstrate the possible correlations between vitamin D and: Addison’s disease, Cushing disease, hyperaldosteronism or adrenocortical tumors. Moreover, this fascinating hormone and adrenal gland even seem to be deeply connected by common genetic pathways. This review aimed to analyze the works that have tried to study the possible influence of vitamin D on adrenal diseases. In this review we analyze the works that have tried to study the possible influence of vita-min D on adrenal disease.
Integrating machine learning with electronic health record data to facilitate detection of prolactin level and pharmacovigilance signals in olanzapine-treated patients
Authors: Zhu Xiuqing , Hu Jinqing , Xiao Tao , Huang Shanqing , Shang Dewei , Wen Yuguan
Published: October 2022

Background and aim

Available evidence suggests elevated serum prolactin (PRL) levels in olanzapine (OLZ)-treated patients with schizophrenia. However, machine learning (ML)-based comprehensive evaluations of the influence of pathophysiological and pharmacological factors on PRL levels in OLZ-treated patients are rare. We aimed to forecast the PRL level in OLZ-treated patients and mine pharmacovigilance information on PRL-related adverse events by integrating ML and electronic health record (EHR) data.

Methods

Data were extracted from an EHR system to construct an ML dataset in 672×384 matrix format after preprocessing, which was subsequently randomly divided into a derivation cohort for model development and a validation cohort for model validation (8:2). The eXtreme gradient boosting (XGBoost) algorithm was used to build the ML models, the importance of the features and predictive behaviors of which were illustrated by SHapley Additive exPlanations (SHAP)-based analyses. The sequential forward feature selection approach was used to generate the optimal feature subset. The co-administered drugs that might have influenced PRL levels during OLZ treatment as identified by SHAP analyses were then compared with evidence from disproportionality analyses by using OpenVigil FDA.

Results

The 15 features that made the greatest contributions, as ranked by the mean (|SHAP value|), were identified as the optimal feature subset. The features were gender_male, co-administration of risperidone, age, co-administration of aripiprazole, concentration of aripiprazole, concentration of OLZ, progesterone, co-administration of sulpiride, creatine kinase, serum sodium, serum phosphorus, testosterone, platelet distribution width, α-L-fucosidase, and lipoprotein (a). The XGBoost model after feature selection delivered good performance on the validation cohort with a mean absolute error of 0.046, mean squared error of 0.0036, root-mean-squared error of 0.060, and mean relative error of 11%. Risperidone and aripiprazole exhibited the strongest associations with hyperprolactinemia and decreased blood PRL according to the disproportionality analyses, and both were identified as co-administered drugs that influenced PRL levels during OLZ treatment by SHAP analyses.

Conclusions

Multiple pathophysiological and pharmacological confounders influence PRL levels associated with effective treatment and PRL-related side-effects in OLZ-treated patients. Our study highlights the feasibility of integration of ML and EHR data to facilitate the detection of PRL levels and pharmacovigilance signals in OLZ-treated patients.
Emerging trends and hotspots in the links between the gut microbiota and MAFLD from 2002 to 2021: A bibliometric analysis
Authors: Li Yixuan , Zhou Yanyu , Wang Liya , Lin Xiaoqi , Mao Menghan , Yin Suqing , Zhu Ling , Jiao Yingfu , Yu Weifeng , Gao Po , Yang Liqun
Published: October 2022

Background

The prevalence of metabolic associated fatty liver disease (MAFLD) presented a booming growth over recent years in the whole world. MAFLD was associated with a higher risk of end-stage liver disease, hepatocellular carcinoma and liver transplantation. Accumulating evidence indicated that gut microbiota and MAFLD were interrelated and interacted with each other. However, to the knowledge of the authors, no bibliometric quantitative analysis has been carried out to evaluate the links between the gut microbiota and MAFLD. This study aimed to use bibliometric analysis to evaluate current publication trends and hotspots in the links between the gut microbiota and MAFLD, in order to advance research in this field.

Methods

The articles regarding the links between gut microbiota and MAFLD from 2002 to 2021 were identified from the Science Citation Index-Expanded of Web of Science Core Collection. CiteSpace software, Vosviewer, the R package “bibliometrix” and the Online Analysis Platform of Literature Metrology were used to analyze current publication trends and hotspots in this field.

Results

A total of 707 articles were retrieved regarding the links between gut microbiota and MAFLD from 2002 to 2021. The USA occupied the leading role until 2015 and the dominance of China started in 2016. The USA was the most frequently involved country in international cooperation. Shanghai Jiao Tong University was the most productive institution. Ina Bergheim was the most productive author, publishing 14 articles. The co-citation keywords cluster label displayed ten main clusters: probiotics, bile acid, immune function, adolescents, nutritional genomics, high fat diet, systems biology, lipopolysaccharides, phosphatidylcholine, and oxidative stress. Keyword bursts analysis indicated that diet induced obesity, metabolic syndrome, ppar alpha, and lactobacillus were the research hotspots with high strength.

Conclusion

The number of publications covering the links of gut microbiota and MAFLD increased dramatically in the past decade and especially became exponential growth in the last 3 years. Probiotics and bile acid will be the research direction of great importance in the etiology and novel treatment for MAFLD. This study provided systematic information and instructive assistance for future research work, that helped to discover the mechanisms and new treatments of MAFLD.
RETRACTED: Post COVID green intellectual capital management with the mediation of organizational learning capability
Authors: Schislyaeva Elena Rostislavovna , Krasovskaya Inna Petrovna , Plis Kristina Sergeevna
Published: October 2022

This study aims to investigate the features of managing intellectual capital regarding the influence on firm performance in the Russian banking sector after COVID-19. The study considered general importance of intellectual capital firm’s bundle of all knowledge assets that can be utilized for different strategic moves. The research used primary data collected from managers in the Russian financial sector using a structured questionnaire from 364 respondents. The intellectual capital aspects used were human, relational, and structural capital. Organizational learning capability was a mediator, while firm performance was the independent variable. The hypotheses were evaluated using Structural Equation Modeling. The study results indicated that relational and human capital have a positive and significant influence on firm performance, but not structural capital. Relational capital, structural capital, and human capital were found to positively and significantly influence firm performance. Organizational learning capability was found to have a positive and significant effect on firm performance and a mediator of the impact of intellectual capital on firm performance. The study recommends that managers in the banking sector enhance their relations and interactions with customers, suppliers, and trade partners.
Genotype and age of industrial plant Jatropha curcas L. affect physico-chemical properties of seed oil
Authors: Islam A. K. M. Aminul , Yaakob Zahira , Ghani Jaharah A. , Alareefy Azza , Abdulsalam Nisreen M. , Khateeb Najla A. , Zidan Nahla , Abdelazi Mahmoud A. , El Sabagh Ayman , Sakran Mohamed I. , Omran Awatif , El Askary Ahmad , El-Sharnouby Mohamed , Aziz albalawi Marzough , Mominul Islam A. K. M.
Published: October 2022

Jatropha curcas, has been established as a plant whose seeds contain a relatively high percentage of oil that is suitable for biodiesel production, among other industrial applications. Seed oil properties of J. curcas may vary depending on soils, age of plant, genotype of the plant, and agro-climatic conditions of a specific geographical region. Studies under such conditions have not yet been conducted. The present study was aimed at investigating the effects of genotype and age of the plant on the physicochemical properties of its seed oil. The seed oil was extracted using n-hexane as a solvent in the Soxhlet extraction apparatus from seed kernel collected from different genotypes and plants of different ages. Oil content in the kernel ranged from 49.78–53.75% (w/w) among the seed samples depending on genetic materials and plant age. The oil content showed very little but significant differences in density and specific gravity among the samples. The highest free fatty acid (FAA) was produced by the kernel oil of 3-year-old plants (7.78%), and 7- and 10-year-old plants gave the lowest FAA (1.26 and 1.31%, respectively). The kernel oil of 7-year-old plants produced the highest iodine value (93.60 mg/g oil) and the kernel oil of 3-year-old plants produced the lowest iodine value (61.10 mg/g oil). Kernel oil of 10-year-old plants gave the lowest (172.98 mg KOH/g) saponification value and 4-year-old Hybrid-3 gave the maximum value (209.97 mg KOH/g oil). The seed oil of Jatropha accessions showed very little difference (39.88–40.85 MJ/kg) for high heating values irrespective of their age. On the other hand, the cetane number varied from 55.32 to 59.58 in the oil samples. The age of plant and seed sources had a significant effect on seed oil content and the physio-chemical properties of Jatropha.
Blood oxygen saturation is lower in persons with pre-diabetes and screen-detected diabetes compared with non-diabetic individuals: A population-based study of the Lolland-Falster Health Study cohort
Authors: Laursen Jens Christian , Jepsen Randi , Bruun-Rasmussen Neda Esmailzadeh , Frimodt-Møller Marie , Jørgensen Marit Eika , Rossing Peter , Hansen Christian Stevns
Published: October 2022

Aims

Low blood oxygen saturation is associated with increased mortality and persons with diabetes have sub-clinical hypoxemia. We aimed to confirm the presence of sub-clinical hypoxemia in pre-diabetes, screen-detected diabetes and known diabetes.

Methods

Pre-diabetes was defined as hemoglobin A1C (HbA1C) ≥ 42 mmol/mol and <48 mmol/mol; known diabetes as history or treatment of diabetes; screen-detected diabetes as no history or treatment of diabetes and HbA1C ≥ 48 mmol/mol. Blood oxygen saturation was measured with pulse oximetry. Urine albumin-to creatinine ratio (UACR) was measured on a single spot urine.

Results

The study included 829 adults (≥18 years) with diabetes (713 (86%) with known diabetes; 116 (14%) with screen-detected diabetes) and 12,747 without diabetes (11,981 (94%) healthy controls; 766 (6%) with pre-diabetes). Mean (95% CI) blood oxygen saturation was 96.3% (96.3% to 96.4%) in diabetes which was lower than in non-diabetes [97.3% (97.2–97.3%)] after adjustment for age, gender, and smoking (p < 0.001), but significance was lost after adjustment for BMI (p = 0.25). Sub-groups with pre-diabetes and screen-detected diabetes had lower blood oxygen saturations than healthy controls (p-values < 0.01). Lower blood oxygen saturation was associated with higher UACR.

Conclusions

Persons with pre-diabetes and screen-detected diabetes have sub-clinical hypoxemia, which is associated with albuminuria.