bluuebunny/crossref_metadata_2025 huggingface dataset:
Changes in hematological and biochemical blood parameters in cats with azotemia
Authors: Chumak V. O. , Harashchuk M. I. , Gordiienko Iu. A. , Haluzina L.I.
Published: February 2025

Acute and chronic forms of renal failure, regardless of the cause of the appearance in cats, cause significant changes in homeostasis. The data estimation of both clinical and laboratory studies of biological fluid samples from the animals makes it possible to detect abnormal changes. Difficulties in the establishing of the final diagnosis may be related to the interpretation of the results of blood counts. Classical changes in the blood are not always detected due to the individual characteristics of compensatory reactions in individual animals. The hemoglobin concentration, erythrocyte count, and hematocrit level were decreased in azotemia-affected animals in compare with non-azotemic. Inversely, the glucose content was increased in azotemia-affected group in compare with non-azotemic. A positive correlation with the values of creatinine in azotemia, has urea r=+0.734, inorganic phosphorus r=+0.727, total cholesterol r=+0.641, ALT activity r=+0.725, AST activity r=+0.57, erythrocytes r=+0.554, and negative hemoglobin r=–0.73, hematocrit r=–0.68. Disorders of diuresis are accompanied by changes in parameters in some sick cats. 63% of animals have decreased levels of calcium and total cholesterol, whereas 38% have increased levels of inorganic phosphorus. These changes become more pronounced as azotemia increases. The frequency of hyperglycemia, decreased hematocrit, hypohemoglobinemia, and erythropenia increases, and the frequency of thrombocytopenia remains at 63% of animals regardless of the presence of azotemia. Half of the animals had changes in the protein composition of the blood, but the same number of cats had normal blood leukocyte levels, leukocytosis, and leukopenia.
Society 5.0 sebagai Bagian dari Kontribusi Warga Wilayah Pesisir (Studi Kasus: Mangunharjo, Semarang)
Authors: Fithor Alin , Nugroho Beni Sabdo , Baihaqi Ahmad Fauzan , Meilala Bryna Rizkinta Sembiring
Published: February 2025

Mangunharjo Beach, Semarang, is not just a beach, but there are residents who contribute to every development that combines natural beauty, the latest technology, and the spirit of mutual cooperation, this beach is transformed into a living laboratory to realize the concept of Society 5.0. The purpose of this study is to determine the extent of the scientific renewal of the Mangunharjo community. The study was conducted by analyzing field surveys of groups of people who were carried out randomly. With the contribution of the community, coastal cities, community concerns and community pressure, In addition to the digitalization of smart cities, this location inspires to create a better future, technology is not just a tool, but also a bridge to connect humans and nature.
Prior land use shapes the functional composition of tree-seedling communities along a tropical forest chronosequence
Authors: Tamargo López Eva , Martinelli Elis , Müller Tobias , Donoso David , Endara María-José , Blüthgen Nico , Unsicker Sybille , Heer Katrin , Farwig Nina
Published: February 2025

Tropical rainforests are highly threatened by deforestation, yet they have the potential to regrow naturally when left abandoned. To understand natural recruitment, it is essential to explore the recovery of tree-seedlings and their traits within the community assembly of secondary forests. Here, we studied the taxonomic and functional diversity as well as the composition of tree seedling communities in 39 plots along a chronosequence of forest recovery, ranging from 0 - 38 years after cacao production or pasture abandonment. We measured leaf traits related to the life strategy (acquisitive or conservative) of all tree-seedling species and determined the surrounding forest cover within a 500 m radius around each plot. Our results showed that the abundance, species diversity, and functional diversity of tree seedlings were increasing, and that the seedling composition was becoming more similar to old-growth forests with increasing time since the onset of recovery, even if it was nowhere near the composition of primary rainforests. The abundance of tree seedlings and their species diversity increased with increasing forest cover. Remarkably, the functional composition of the communities on plots formerly used for pasture was characterized by acquisitive traits, while former cacao plots and old-growth plots were associated with conservative traits, highlighting the role of prior land use in seedling recruitment. Synthesis: Our study showed that forest recovery is a complex and multifactorial process. Forest cover is a key factor accelerating natural forest recovery, while prior land use may limit functional recovery, potentially affecting ecosystem functioning.
The Role of HRM in Shaping Inclusive Cultures: Navigating Cross-Cultural D&I Challenges in U.S. Organizations
Authors: Lima Sungida Akther , Rahman Md. Mostafizur , Bhuiyan Md Imranul Hoque , Rahman Zahidur
Published: February 2025

This paper looks at the stewardship duties of Human Resource Management (HRM) in the promotion of diverse workplace cultures across various organizations within the United States of America. In today’s diverse workplace across the world, organizations have wised up to the fact that Diversity and Inclusion (D&I) initiatives are strategic business imperatives for lasting organizational success. This paper looks at how the various HRM processes, including recruitment and selection, onboarding, leadership, and development, as well as performance management, may be used to support D&I efforts, leading to diverse and talented employees being welcomed and supported in organizations. Evaluating a variety of strategic D&I interventions, including unconscious bias training, the role of the mentorship program, and technology-supported monitoring, the paper shows that through HRM it is possible to manage the issues of cross-cultural D&I. On workplace diversity, it describes how organizations can create a culture that will not only increase the overall staff morale but also increase innovation as well as the overall performance of organizations. Moreover, the paper presents case studies that might illustrate how the HRM may become the key driver of successful D&I practices, cultural change, and business impact. The long-term advantages of D&I, which are better retention, creativity and relations with clients, are explained further. As highlighted in this paper, leadership support and the role of HR professionals in policing accountability remain key to the organizational change. This calls for commitment from HRM to ensure that D&I isn’t an afterthought in the business world but a major component that puts into practice organizational social responsibility and excellence. As a closing note, there is an appeal to HR professionals to embrace positive, evidence-based approaches to applied policies that contribute to Diversity and balance organization’s development.
La brecha digital en el estado de Aguascalientes
Authors: Guzmán Mendoza José Eder , Muñoz Arteaga Jaime , Álvarez Rodríguez Francisco Javier , Velázquez Amador César Eduardo
Published: February 2025

El uso de las tecnologías de la información y comunicación (TIC) es uno de los elementos clave para la transformación de las sociedades en sociedades de la información y del conocimiento. Sin embargo, la diferencia en el acceso y uso de las TIC ha contribuido a la generación de un problema de “brecha digital” entre la población que impide el desarrollo económico y humano a nivel individual y colectivo. Es así que las instituciones de educación, gobiernos y empresas cumplen un papel importante a través de la creación de espacios comunes de libre acceso para población en diferentes comunidades y algunos municipios, además de proporcionar equipos de cómputo para recibir capacitación en su uso. El objetivo principal de esta revisión es dar una apreciación de la situación del estado de Aguascalientes respecto a la brecha digital para los puntos de infraestructura, alfabetización digital y estrategias gubernamentales en un contexto nacional.
Análisis jurídico sobre la aplicación del Estatuto de la Oposición en los concejos municipales de Pereira y Valledupar, durante el periodo comprendido entre el 2 de enero y el 31 de julio de 2020
Authors: Serna Alzate Margarita Maria
Published: February 2025

El Congreso de la Republica promulgó la  Ley 1909 de 2018, la cual regula el ejercicio del derecho fundamental a la oposición política. De allí entonces surgió la necesidad de realizar un proyecto de investigación enfocado al seguimiento respecto a la aplicación del nuevo Estatuto, para determinar cómo había sido su implementación en las Corporaciones político-administrativas más cercanas a la ciudadanía: los Concejos Municipales. El estudio se centro específicamente en los concejos municipales de Pereira y Valledupar, indagando si sus actuaciones y disposiciones normativas se han adecuado a lo dispuesto por Ley en mención, dentro de un periodo específicamente determinado. Así mismo, identificando el contenido jurídico dispuesto en el Estatuto de la Oposición que fuera aplicable a los Concejos Municipales, para posteriormente establecer cuáles eran los partidos y/o movimientos políticos declarados en oposición y finalmente verificar cuáles fueron las acciones desplegadas por estas corporaciones públicas. Todo lo anterior, en el marco de una Investigación mediada por un diseño mixto (con elementos cualitativos y cuantitativos), utilizando el enfoque histórico hermenéutico. Finalmente se procederá a presentar los resultados producto de la investigación realizada en relación con los instrumentos aplicados.
"Salud visual para todos": la presencia del programa de Optometría de Areandina en su comunidad en tiempos de pandemia en Pereira 2020
Authors: Márquez Galvis Mónica Marlene
Published: February 2025

Este documento de trabajo tiene como objetivo divulgar las actividades que realizó el programa de Optometría desde la Proyección Social para mantener la asistencia de la salud visual de su comunidad. Debido a la situación ocasionado por la pandemia de la COVID-19, existe un gran temor a asistir a consulta presencial, derivando en que las personas se abstengan de consultar su estado con el optómetra; en respuesta se realizó capacitaciones en prevención y promoción para estudiantes de la Fundación Universitaria del Área Andina (Areandina), padres, profesores y estudiantes de instituciones educativas y de primera infancia de Pereira; y con el apoyo de los estudiantes de Vinculación (proyección social) de la Universidad Técnica de Manabí (UTM) a la comunidad de UTM y sus familias. Los estudiantes diseñaron material audiovisual para promover los estilos de vida saludable, la salud visual y el uso adecuado de los dispositivos electrónicos. Esta experiencia mostró que la prevención y promoción de la salud visual es necesaria en todos los países, y que se puede realizar de manera exitosa a través de alianzas con la academia de cada país; dando un mayor alcance a las acciones de proyección social, se fortalecen los lazos de cooperación internacional y la comunidad intercambiaexperiencias culturales. La población en primera infancia continúa necesitando acompañamiento en prevención y promoción de la salud visual, la educación a los padres y maestros debe ser permanente para mejorar la cooperación y la adherencia a las recomendaciones. El programa de Optometría de Areandina cuenta con el compromiso de los docentes y estudiantes por esto debe fortalecer los mecanismos de seguimiento de loscasos remitidos.
Conocimientos sobre tuberculosis en personas recluidas en un centro penitenciario de la ciudad de Pereira
Authors: Alvarez López Angela María , Arboleda Gleydiz
Published: February 2025

: Las personas recluidas en centros carcelarios tienen factores que los predisponen a la tuberculosis pulmonar; el hacinamiento carcelario, la poca ventilación, iluminación y la falta de espacios abiertos en estos sitios predisponen a un mayor riesgo de transmisión de la enfermedad. Objetivo: Determinar el nivel de conocimiento sobre tuberculosis pulmonar en hombres privados de la libertad de un centro penitenciario de la ciudad de Pereira. Materiales: Se realizó una prueba de conocimientos antes y después de una serie de capacitaciones sobre tuberculosis pulmonar, contando con la autorización y acompañamiento de la Personería de Pereira. Resultados: Previo a las capacitaciones el 31% de la población no sabía que es la tuberculosis pulmonar; después de las intervenciones educativas el 94% de los encuestados tiene conocimiento sobre esta enfermedad, medios de transmisión y formas de prevenirla. Conclusiones: Las personas recluidas en los centros carcelarios tienen una mayor prevalencia de contagio de la TBC pulmonar; el diagnostico no oportuno subraya la importancia de la educación continua y la disminución de los porcentajes de transmisión.
Agriculture in interwar Poland: development in a turbulent time
Authors:   University of Warsaw, Faculty of Economic Sciences, Bukowski Maciej , Kowalski Michał ,   University of Warsaw, Faculty of Economic Sciences, Wroński Marcin ,   Warsaw School of Economics, Collegium of World Economy, Minda de Gunzburg Center for  European Studies
Published: February 2025

We measure the value added in agriculture in Poland during the interwar period. Our
calculation is based on the bottom-up methodology. We provide estimates on the national and
regional levels. Cultivated area, yields and yields per hectare increased during the investigated
period. Significant regional convergence, both in the case of prices and value added occurred. In
the years 1924 -38 value added increased by 5.35% annually, resulting 4.01% per capita growth
rate. However, the yields per hectare grew less than in a majority of other European economies.
While less developed eastern regions caught up with more economically advanced western
Poland, the leading west lost compared to European peers. Therefore, our assessment of the
development of agriculture in Poland in that period remains mixed.
The Economic Growth and Regional Convergence in Interwar Poland: Detailed Historical National Accounts
Authors:   University of Warsaw, Faculty of Economic Sciences, Bukowski Maciej , Kowalski Michał ,   University of Warsaw, Faculty of Economic Sciences, Wroński Marcin ,   Warsaw School of Economics, Collegium of World Economy, Minda de Gunzburg Center for  European Studies
Published: February 2025

We provide the first estimate of the Polish national, regional and sectoral GDP in the
interwar period. We find that the Polish economy's performance in the interwar period was much
better than it was assumed before. In the years 1924 – 1938, the real GDP per capita increased by
almost 40% or by 2.3% annually. As economic growth was stronger in the poorer regions
significant regional convergence was achieved. Our results challenge the dominant narrative
about the weak performance of the Polish economy in the interwar years.
Novel Electrostatic Spray Deposition (ESD) Techniques for Growth Mechanisms of Solution-Dependent Zinc Oxide (ZnO) Thin Films
Authors:   Department of Electrical Engineering, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278- 8510, Japan, Ibna Abbas Fysol
Published: February 2025

In this work, a systematic and easy approach to nanocrystalline (NC) ZnO thin films growth by employing the novel
ESD technique at temperatures ranging from 300 °C to 500 °C have been studied. For the subsequent investigation,
three sets of 20 ml spray solutions with a 0.1 M concentration of the ESD technique were generated within the laboratory
facilities. The solutions contained 80% ethanol (CH3
CH2
OH) and 20% distilled water (H2
O). Zinc chloride (ZnCl2
) was
utilized as the zinc source for all the 20 ml solution. In order to address the fundamental causes of the microstructural
changes, two sets of the spray solution were enhanced with hydrochloric acid (HCl) at concentrations of 0.005 M and
0.015 M, respectively. X-ray diffraction (XRD) depictions showed that the ZnO nanoparticles had a pristine wurtzite
crystal structure. Energy dispersive X-ray spectroscopy (EDS) and scanning electron microscopy (SEM) showed the
composition ratio and growth confirmation of ZnO on the conductive In2O3:Sn (ITiO) coated alkali-free glass substrates.
The results show that adding the maximum amount of HCl to the spray solution suppresses the c-axis crystal growth of
ZnO thin films and enhance the a-axis (100) crystal growth. The adhesion of anions was believed to be responsible for
this suppression. Microstructural parameters (MIP), specifically lattice parameters (a (Å), c (Å)), positional parameters
(μ), bond lengths (L (Å)), full width at half maximum (FWHM), and average crystallite sizes (D (nm)), are examined.
This finding signifies a pivotal advancement in cost-efficient industrial and commercial applications for ESD-deposited
devices.
Naming the Child: Entering the Maternal Genealogy in Valeria Parrella’s Lo spazio bianco
Authors: Benchi Paola
Published: February 2025

Naming is usually seen as the first action that inscribes the newborn in a patriarchal genealogy, assigning to the subject a role, a position, and an identity in the symbolic order. However, it is possible to find ruptures that allow for a different signification, shifting the emphasis towards a maternal genealogy. The passage from a paternal to a maternal genealogy offers a perspective for a reading of Valeria Parrella’s Lo spazio bianco (2008).
Maria, the 42-year-old protagonist of this book, gives birth to a premature baby girl after only six months of pregnancy. The baby is put in an incubator in the hope that she can grow and survive. At one point in the story, Maria decides to name her baby. I suggest that Maria’s act of naming her baby girl can be seen as an event which subverts the traditional mother/daughter role assigning Maria and her daughter their new subject-positions according to a maternal genealogy.
Starting with an analysis of a number of feminist theorists’ take on naming, I will then examine the process of naming in Lo spazio bianco in the light of some of the theories on maternal/feminine subjectivity. I will integrate Luce Irigaray’s theory of maternal genealogy with notions derived from objectrelations psychology such as Jessica Benjamin’s “intersubjective space”, Nancy Chodorow’s and Jane Flax’s different ideas of mother/daughter relationships, and Christopher Bollas’ “unknown thought”; Lisa Baraitser’s Maternal Encounters will provide the focus for my analysis, while Bracha L. Ettinger’s “matrixial borderlinking trans-subjectivity” will be the final key for the reading of Maria’s delayed maternal subjectivity.
Beyond Duality: the ‘Choreography’ of Gender in Dacia Maraini’s novels
Authors: Morelli Maria
Published: February 2025

Dacia Maraini has created a body of work that questions the mechanisms of oppression and manipulation at play within the economy of a heterosexual regime. This means challenging the role of women inasmuch as they are primarily identified as wives and mothers, a challenge linked to and emerging from the questioning of the notion of the (female) body as performing certain gender roles which are, in Judith Butler’s words, ‘a legacy of sedimented acts’ (Butler, 1988).
Following this line of enquiry, in this article I will be looking at the question of female sexuality as tackled in three works by Dacia Maraini: Donna in Guerra (1975), Storia di Piera (1980) and Lettere a Marina (1981). I shall posit that, although at odds with the gender roles patriarchal society would expect them to fulfil, the female characters portrayed in these texts do not seem willing to embrace an exclusive sexuality either. Rather, they would appear more inclined to perform what Butler defines as a ‘process’ or a ‘becoming’ (Butler, 1988) or, in my reading, Jacques Derrida’s utopia of a ‘choreography’ of gender (Derrida and McDonald, 1982), understood as an adamant rebuttal of any essentialist, prescriptive, interpretation of gender and sexuality.
In Maraini’s narratives gender formation translates into an on-going process which—resonating with a Derridean utopia—becomes less a matter of seeking a unifying subject than of expressing the blurring of the boundaries of a single, unitary category.
Ecos de Eureka, de Edgar Allan Poe, en la literatura española de principios del S. XX
Authors: Penón José Luís
Published: February 2025

En este artículo proponemos un estudio comparativo de la obra de Edgar Allan Poe Eureka, de 1848, y la obra de diversos autores hispanos de finales del SXIX y principios del SXX. Estudiaremos su contenido y la opinión que generó en la crítica y los académicos. Cómo estas ideas viajaron al otro lado del Atlántico y la influencia o ecos que produjo esta obra, y otras relacionadas, en la literatura de ciertos autores hispanos.
Se trata del único libro que Poe escribió en vida, y del cual estaba muy orgulloso. Eureka es un desconocido para la mayoría, y un olvidado para la crítica y los academicistas. Analizaremos cómo Poe, y sobre todo sus ideas llegan, influyen y se plasman posteriormente en las obras de nuestros autores.
En Eureka, podemos apreciar la relación tan próxima que existe entre su filosofía de vida y su filosofía literaria. Se trata de la expresión más contundente de su “Yo material” y de su “Yo espiritual”, que terminará por cerrar ese círculo de conexiones entre el Poe ser humano, y el Poe artista. Esta cosmovisión metafísica es tratada, asimilada y experimentada de diferente forma por distintos de nuestros literatos como Unamuno, Machado y Juan Ramón.
Essay - Dragon Slayers and Lion Friends: Intertextual Considerations in Tochmarc Emire
Authors: Theuerkauf Marie-Luise
Published: February 2025

There was a tremendous response to the Graduate School of the CACSSS’ inaugural PhD Essay Prize. The essays were reviewed by all the members of the Graduate School Executive Board. The process highlighted the excellent, engaged research being undertaken by postgraduate researchers
across the disciplines in the college. The finalists were further double blind peer reviewed by national and international experts in the respective fields. It is with great pleasure that we now publish the inaugural recipient’s essay in this edition of Aigne, the postgraduate journal of the College of Arts, Celtic Studies and Social Sciences, at University College
Cork.

- Orla Murphy, Graduate School Executive Committee
Justice Done? An Analysis of One Aspect to the 2006 Irish High Court Ruling in Zappone and Giligan v. Revenue Commissioners and Attorney General
Authors: Mullins Jackie
Published: February 2025

In this article, I conduct an analysis of extracts from the 2006 High Court ruling in the matter of Zappone and Gilligan v. Revenue Commissioners and Attorney General. This case centred on the issue of same-sex marriage in Ireland. While there were a number of important aspects to this ruling, I elaborate on one issue, i.e. child development in the context of the parenting that is done by lesbians and gay men. I focus on some of the research studies that informed expert witness testimony on behalf of the plaintiffs and the State in this case. Firstly, I provide an analysis of some of the research findings in an American study, which denoted a review of a number of child development research studies that were conducted in the 1980s and 1990s. In that regard, I problematise the routine reproduction of heteronormativity. With regard to the State's case, I discuss the
interpretation of a research study that was conducted in the 1980s by a team of
researchers in the United States. I also highlight aspects of an affidavit that was initially sworn into evidence in a same-sex marriage case in Canada. I discern errors in some of this expert testimony that was enunciated and interpreted with a view to furthering the Irish State's case. Neither the routine reproduction of heteronormativity, nor the repeated articulation of erroneous testimony garnered attention in the High Court. I argue that these dynamics denote problematic aspects to the ruling in Zappone and Gilligan v. Revenue Commissioners and Attorney General.
Writing Saudade: Navigating Home, Homeland, and Sexuality in the Work of Gabriela Mistral and Elizabeth Bishop
Authors: Clawson Corey D
Published: February 2025

For poets Elizabeth Bishop and Gabriela Mistral, the potential of Portuguese saudade was an answer to anguish they experienced as exiles and other forms of loss. Drawing upon their poetry, correspondence, and translations of Lusophone literature, this paper examines how, by engaging with this foreign concept, both queer women poets living in exile engaged with their own senses of isolation, alienation, and unhomeliness. Describing the potential of saudade in an endnote to the section titled “Saudade” in Tala, her third volume of poetry first published in 1938, Mistral states “I firmly believe […] in a future of borrowing language to language in Latin America. At least, in the case of certain words, definitive profit from the genius of the other, unshakable expressions within their range of ‘true’ words” (2003 p. 244). Both of these poets turned to this word as they were reconciling the heteronormative forces displacing them within their homelands. Ultimately, Bishop and Mistral mobilize the notion to address the traumas of displacement, loss, and sexual difference as they explore the “truth” and nuance of the word through their writings.
Anne Enright's The Gathering: The Five Stages of Grief in a Liminal Space
Authors: Bonass Madden Margaret
Published: February 2025

Applying Kübler-Ross’s theory of the Five Stages of Grief to a reading of Anne Enright’s 2007 novel The Gathering, this paper will trace the journey through grief and how it is a flexible entity which affords different reactions and experiences of grief within the liminal space. The Kübler-Ross theory defines the stages of grief within five parameters: Denial and Isolation; Anger; Bargaining; Depression; Acceptance. She notes how the immediate days after the death are filled with viewings, organising travel itineraries and funeral arrangements. These days are a blur of paperwork and shock and are often accompanied by loss of appetite, lack of sleep and a removal from reality.  It is when the burial is complete, and the mourners have departed, that the process of grief can re-commence. Enright’s The Gathering focuses on the aftermath of the death of Liam Flaherty and the subsequent gathering of the Flaherty family for his wake and funeral. The Five Stages of Grief are applied in a non-linear form, enabling a more nuanced situational narrative within the liminal space.  In The Gathering, we follow Veronica Hegarty’s stages of grief, following the suicide of her younger brother, and observe how she chooses – for the most part – to cope in isolation. The liminal space afforded to Veronica enables her to process her grief through the medium of memory and her composition of an (imagined) biography of her grandmother. Enright’s unreliable protagonist is creating a bio-fictional past whilst dealing with a stark present. Grief is a personal journey and closure is not always inevitable.
Same Quadrant Trabeculectomy after Failed Ab Externo Open Conjunctiva XEN Stent Implantation
Authors: Heo Jun , Lee Joohwang , Kim Hwayeong , Moon Sangwoo , Lee Jiwoong
Published: February 2025

Purpose: Conjunctival incisional surgery is a known risk factor for trabeculectomy failure. The occurrence of avascular bleb following failed ab interno XEN stent implantation has been documented in patients undergoing trabeculectomy with mitomycin C (MMC). However, reports on same quadrant trabeculectomy with MMC after failed ab externo open conjunctiva XEN stent implantation are scarce. This study sought to document the 1-year clinical outcomes and bleb morphology following this procedure.Case summary: This retrospective study reviewed the medical records of 4 eyes from 4 patients who received trabeculectomy with MMC in the same quadrant following ab externo open conjunctiva XEN stent implantation failure. At 1 year after trabeculectomy, the intraocular pressure was successfully controlled without glaucoma medication, and no visual field progression was observed. Anterior segment tomography indicated that the blebs were elevated and broad, with a suprascleral fluid-filled space evident in all eyes. There were no instances of prolonged hypotony or bleb leakage one year after the trabeculectomy, although an avascular bleb was observed in one eye.Conclusions: Performing trabeculectomy with MMC in the same quadrant appears to be an effective method for reducing IOP after the failure of ab externo open conjunctiva XEN stent implantation.
Deutsch in der Grundschule
Authors: Marx Konstanze , Hoferichter Max
Published: February 2025

Dieser Band ermöglicht Grundschullehrkräften, sich gezielt den wesentlichen Aspekten der Deutschdidaktik zu nähern, indem er eine systematische Recherche didaktischer Fragestellungen, insbesondere zur Entwicklung von Schreib-, Erzähl- und Argumentationskompetenzen, unterstützt. Die Literatur sensibilisiert für die Vor- und Nachteile diverser Methoden, wobei der Schriftspracherwerb und die Lesekompetenz im Fokus stehen, da diese nicht ohne didaktische Anleitung erworben werden können.

Ein wesentlicher Teil der Literatur adressiert aktuelle Herausforderungen, wie das Fehlen einheitlicher Vermittlungsmethoden oder die multifaktorielle Heterogenität in den Klassen. In diesem Zusammenhang sind interkulturelle Kompetenzen unerlässlich, um mit den unterschiedlichen Wissensständen und sprachlichen Voraussetzungen der Kinder umzugehen. Der Band diskutiert zudem neue Ansätze für den Einsatz digitaler Medien, bietet Informationen zu kompetenzfördernden Unterrichtsmaterialien und hebt die Bedeutung von Mehrsprachigkeit als Ressource hervor.
Makermat no 5º ano do Ensino Fundamental
Authors: Gondim Raquel de Sousa , Serafim Ruth de Sousa Gondim , Gondim Raianny de Sousa , Ribeiro Ana Paula de Medeiros , Vasconcelos Francisco Herbert Lima
Published: February 2025

O problema central abordado neste estudo é a busca por estratégias pedagógicas inovadoras e eficazes que possam contribuir para a melhoria do aprendizado dos conteúdos de matemática no 5º ano do Ensino Fundamental. Dessa forma, o objetivo é analisar o processo de aprendizagem de conteúdos matemáticos por parte de alunos do 5º ano do Ensino Fundamental mediante a aplicação de sequências didáticas que utilizam atividades MakerMAT. Com o intuito de atender a esse objetivo, guiamo-nos metodologicamente pelos pressupostos da pesquisa qualitativa, que possui uma natureza exploratória. Para tanto, optou-se por utilizar os princípios metodológicos da pesquisa-ação no desenvolvimento de uma sequência didática. Nesse sentido, a sequência didática foi aplicada em uma escola da rede de ensino do município de Fortaleza. Além disso, a análise dos dados fundamentou-se em Bardin (1977), por meio da aplicação das três fases metodológicas, a saber: 1) pré-análise; 2) exploração do material; e 3) tratamento dos resultados, inferências e interpretação. Por fim, os resultados indicam que, de maneira significativa, a aplicação de sequências didáticas fundamentadas na abordagem MakerMAT contribui para a promoção de um aprendizado mais ativo, colaborativo e significativo dos conteúdos de matemática no 5º ano do Ensino Fundamental. Além disso, os dados evidenciam que, ao serem utilizados materiais didáticos manipuláveis de baixo custo, associados a práticas pedagógicas interativas e à cultura maker, os estudantes apresentam maior engajamento, o que favorece o desenvolvimento do raciocínio lógico-matemático e potencializa a capacidade de resolver problemas de maneira criativa.
Contributos de estudantes potiguares quanto ao uso da sala de aula invertida, aliada à educação ambiental, na aprendizagem de conceitos de geometria
Authors: Da Silva Soares Edivanha , Francisco Barros de Oliveira Glaydson
Published: February 2025

Este artigo é um recorte da dissertação de mestrado, intitulada Sala de aula Invertida no Ensino de Geometria: Contributos para Práticas de Educação Ambiental defendida por um dos autores, a qual objetivou investigar as contribuições de uma proposta de ensino-aprendizagem de Geometria Espacial que integra o estudo de sólidos geométricos com a Educação Ambiental, através da Metodologia Sala de Aula Invertida. A pesquisa foi desenvolvida com duas turmas do 2º ano do Ensino Médio, contando com a participação de 28 estudantes de uma instituição pública, localizada no interior do estado do Rio Grande do Norte. Sob uma abordagem qualitativa, foram desenvolvidas atividades diversificadas distribuídas em espaço físico e virtual, através das quais foi possível a mediação do ensino-aprendizagem de prismas, pirâmides, corpos redondos e temáticas de educação ambiental, com foco na participação ativa e colaborativa. Este artigo apresenta a percepção dos alunos acerca da metodologia sala de Invertida destinada à aprendizagem de sólidos geométricos, tendo como tema transversal a Educação Ambiental, os quais destacam os pontos positivos e negativos desse método de ensino. Com os resultados dessa proposta é plausível inferir que é possível dinamizar a prática docente através de ações que gerem reflexões e aprendizagem, frente aos desafios existentes em metodologias que visam a formação de um cidadão crítico e participativo.
O uso do Geogebra na resolução de problemas para o ensino de matrizes
Authors: Castro Adriane do Socorro Pires , Arruda Suellen Cristina Queiroz
Published: February 2025

O presente trabalho propõe uma atividade diferenciada ao tradicional ensino de matrizes baseada no uso de tecnologias digitais. Buscou-se, a partir da utilização do software GeoGebra na resolução de problemas contextualizados, contribuir com o processo de ensino de matrizes para alunos de duas turmas de 3ª série do Ensino Médio, da rede pública de ensino da cidade de Acará, no estado do Pará. Com uma abordagem qualitativa e de natureza descritiva, utilizaram-se dois questionários direcionados aos alunos: um de diagnóstico e outro de avaliação. Os resultados da pesquisa demonstraram que é possível promover o uso de tecnologias digitais em sala de aula, aliado a problemas contextualizados, para auxiliar na compreensão de conceitos matemáticos sobre matrizes, proporcionando uma aprendizagem mais significativa aos alunos.
Plataforma Genia
Authors: Strogenski Silva Soares Rafael , Carla de Carvalho Leticia , Maiara Seidel Luciano Anne , Aurelio Kalinke Marco
Published: February 2025

A busca por recursos tecnológicos que otimizem o ensino e a aprendizagem da matemática é constante. Nesse contexto, a plataforma GenIA surge como uma possibilidade na criação de Objetos de Aprendizagem (OA), sem a necessidade de conhecimento prévio em linguagens de programação. Esta pesquisa, com abordagem qualitativa, investigou as possibilidades da GenIA para estudantes do Curso de Licenciatura Plena em Matemática da Universidade Tecnológica do Paraná (UTFPR), Campus Curitiba. A pesquisa se fundamentou em dois instrumentos:  acompanhamento detalhado da interação dos estudantes com a GenIA, observando suas experiências e evolução e coleta de dados aprofundados sobre as percepções e avaliações dos estudantes em relação à plataforma (questionário estruturado). Os resultados demonstraram que mesmo sem conhecimento prévio em linguagens de programação, os estudantes de licenciatura em matemática foram capazes de criar OA na plataforma. Eles reconheceram o potencial da ferramenta para tornar as aulas mais interativas e auxiliá-los na formação docente.
Da contagem de camelos à inclusão
Authors: Paiva Thiago Ferreira de , Eustáquio Moreira Geraldo
Published: February 2025

A contação de história tem sido muito utilizada como prática pedagógica em diversas disciplinas e componentes curriculares. O estímulo à imaginação, o desenvolvimento da oralidade e da escrita, o encantamento pela aula, a interação coletiva e, ainda, a contribuição para o desenvolvimento da criticidade, são algumas contribuições da contação de história. Em matemática, não deve ser diferente uma vez que a leitura e interpretação são imprescindíveis para a compreensão de informações matemáticas, como na resolução de problemas, por exemplo. É uma oportunidade de trabalhar e desenvolver atributos relacionados às dimensões afetivas, cognitivas, psicológicas e sociais. Assim, este artigo tem como objetivo caracterizar a contação de histórias como um recurso didático-matemático, utilizando a história contada no capítulo III do livro o Homem que Calculava, escrito por Júlio César de Mello e Souza, o Malba Tahan. Nessa perspectiva, relatamos as contribuições do autor para a educação brasileira, em especial para a Educação Matemática Inclusiva. Inicialmente, trazemos um recorte com suas principais obras e trajetória acadêmica. A pesquisa é do tipo qualitativa, utilizando como metodologia o estudo de caso. Analisamos a contação de histórias como uma ferramenta didática no processo de ensino de matemática com estudantes com deficiência intelectual matriculados nos Anos Finais de Ensino Fundamental da educação básica. Os resultados apontaram que os estudantes demonstraram um entusiasmo crescente e mantiveram alta concentração durante esse estudo, o que resultou na realização eficaz das atividades propostas ao longo da pesquisa.
Construcionismo, pensamento computacional e conceitos matemáticos
Authors: Freitas de Carvalho Sergio , Scherer Sueli
Published: February 2025

Esse artigo teve por objetivo investigar possibilidades de aprendizagem matemática e desenvolvimento de habilidades do Pensamento Computacional, em um ambiente Construcionista de aprendizagem, a partir da produção de jogos digitais. Os dados discutidos foram produzidos em um projeto de Iniciação Científica, com estudantes do Ensino Médio do Instituto Federal de Mato Grosso do Sul, no qual os estudantes produziram diferentes jogos utilizando o software Scratch. Fundamentado em elementos teóricos acerca do Construcionismo e do Pensamento Computacional, o artigo discute o processo de produção de um dos jogos produzidos pelos estudantes. Foi possível observar que o processo de produção de jogos em um ambiente construcionista, com o uso do software Scratch, oportunizou aos estudantes a mobilização e a construção de conceitos matemáticos relacionados a ângulos, coordenadas cartesianas e números inteiros, bem como oportunizou o desenvolvimento de habilidades do Pensamento Computacional.
O quarteto do conhecimento nas práticas dos Professores que Ensinam Matemática
Authors: Carvalho Érick , Gaudencio do Rêgo Rogéria
Published: February 2025

O artigo apresenta o desenvolvimento e os resultados de uma revisão sistemática da literatura sobre o modelo teórico do Quarteto do Conhecimento e que teve como objetivo construir um panorama dos estudos voltados para essa temática no período de 2019 até 2023. Para isso, foi feito uma busca em bases de dados nacionais e internacionais, nas quais foram encontrados 24 artigos para serem analisados a partir de cinco questões norteadoras voltadas para o local de publicação, o tipo de pesquisa, o ambiente aplicado, os instrumentos utilizados e as ampliações propostas para o Quarteto do Conhecimento. Os resultados evidenciam que há um número reduzido de artigos direcionados para essa temática no cenário acadêmico mundial. Nesses últimos cinco anos foram encontrados apenas três artigos publicados no Brasil, um com características de pesquisa bibliográfica e dois com aspectos de uma pesquisa naturalista ou de campo que exploraram as salas de aula dos anos finais do Ensino Fundamental e do Ensino Médio. De acordo com as produções investigadas, o modelo teórico do Quarteto do Conhecimento é relativamente novo e está sujeito às adequações a partir da inclusão de novos códigos contributivos e até de uma nova dimensão.
Piezo1-related physiological and pathological processes in glioblastoma
Authors: Fu Weijia , Hou Xue , Ding Lijuan , Wei Jiaying , Hou Wei
Published: February 2025

Introduction

Glioblastoma (GBM) is the most malignant of the astrocytomas, primarily involving the cerebral hemispheres and cerebral cortex. It is one of the fatal refractory solid tumors with a 5-year survival rate of only 5% in adults. Cells in biological tissues are subjected to mechanical forces, including hydrostatic pressure, shear stress, compression and tension. Cells can convert mechanomechanical signals into biological or electrical signals, a process known as mechanical signaling. Piezo1 channels, members of the Piezo family of mechanosensitive ion channels, can be directly activated by mechanical stimuli alone, mediating mechanosensitive cation currents that activate subsequent signaling pathways. Studies have shown that Piezo1 is largely unexpressed in normal brain tissues but is expressed at high levels in glioblastoma and can significantly contribute to glioblastoma development and progression, but its role in the pathogenesis of glioblastoma remains unclear.

Methods

We reviewed the relevant literature and data in six major databases including PubMed, EMBASE, CINAHL, Scopus, Web of Science and TCGA. Finally, a total of 126 papers were selected for review and analysis (Search terms include: glioblastoma, piezo1, biomechanical, targeted therapy, mechanomechanical, extracellular matrix, radiation therapy and more). The role of piezo1 in the development of glioblastoma was summarized.

Results

Piezo1 affects several fundamental pathophysiological processes in glioblastoma, such as tissue sclerosis, angiogenesis, energy supply, and immune cell infiltration, and can be used as an indicator of malignancy and prognosis in patients with glioblastoma, as well as a therapeutic target to control tumor progression.

Discussion

The pathological mechanism of piezo1 in glioblastoma is very complex, and the aberrant expression of piezo1 plays a very important role in the development of glioblastoma. Specific mechanistic studies focusing on Piezo1 will help us understand the mechanobiology of glioblastoma and help us develop new therapeutic approaches for glioblastoma patients.
Advances and challenges in cell therapy for neuropathic pain based on mesenchymal stem cells
Authors: Zhang Wen-Jun , Pi Xiong-Wei , Hu Dong-Xia , Liu Xiao-Ping , Wu Ming-Ming
Published: February 2025

Neuropathic pain (NPP) is caused by damage to the somatosensory nervous system. Its prominent symptoms are spontaneous pain, hyperalgesia and abnormal pain. This pain is long-lasting and unbearable, seriously affecting the patient’s quality of life. At present, the clinical treatment effect of painkillers to relieve NPP is still not ideal, nor can it repair damaged nerves and achieve long-term treatment results. In recent years, the application of cell therapy strategies in the field of pain has yielded encouraging results, including preclinical studies and clinical trials. Mesenchymal stem cells (MSCs) are pluripotent progenitor cells derived from mesogenesis. They have the ability to self-renew and differentiate into multiple cell types and have been widely studied and applied in the field of neuroregenerative medicine. MSCs play an important mechanism functional role in promoting injured nerve regeneration and pain relief by regulating multiple processes in target cells, including immunoregulation, anti-inflammatory properties, promoting axon regeneration and re-myelination, promoting angiogenesis, and secreting neurotrophic factors. Moreover, MSCs can also release exosomes, which may be part of their analgesic effects. Exosomes derived from MSC also have the functional properties of mother cells and have therapeutic potential for treating NPP by promoting cell proliferation, regulating inflammatory responses, reducing cell death, promoting axon regeneration and angiogenesis. Therefore, in this article, we discussed current treatment strategies for NPP and explored the functional role and mechanism of MSCs in the treatment of NPP. We also analyzed the current problems and challenges in the application of MSCs in clinical trials of NPP.
Mechanisms underlining R-loop biology and implications for human disease
Authors: Liu Junzhe , Li Fengze , Cao Yulong , Lv Yonghui , Lei Kunjian , Tu Zewei , Gong Chuandong , Wang Haiyan , Liu Feng , Huang Kai
Published: February 2025

R-loops are three-stranded non-canonical nucleic acid structures composed of nascent RNA hybridized with the template DNA strand, leaving the non-template DNA strand displaced. These structures play crucial roles in regulating gene expression, DNA replication, and transcription processes. However, R-loops have also been increasingly described as highly deleterious, causing genomic instability and DNA damage. To maintain R-loops at a relatively safe level, complex regulatory mechanisms exist to prevent their excessive formation. The growing understanding of R-loop functions has provided valuable insights into their structure and potential clinical applications. Emerging research indicates that R-loops contribute to the pathogenesis of various disorders, including neurodegenerative, immune-related, and neoplastic diseases. This review summarizes R-loop metabolism and its significance in the etiology of associated disorders. By elucidating the regulatory mechanisms governing R-loops, we aim to establish a theoretical foundation for understanding disease pathogenesis and exploring novel therapeutic strategies targeting these hybrid nucleic acid structures.
Promoting active participation in robot-aided rehabilitation via machine learning and impedance control
Authors: Tamantini Christian , Patrice Langlois Kevin , de Winter Joris , Ali Mohamadi Parham Haji , Beckwée David , Swinnen Eva , Verstraten Tom , Vanderborght Bram , Zollo Loredana
Published: February 2025

Introduction

Active patient participation is crucial for effective robot-assisted rehabilitation. Quantifying the user's Active Level of Participation (ALP) during therapy and developing human-robot interaction strategies that promote engagement can improve rehabilitation outcomes. However, existing methods for estimating participation are often unimodal and do not provide continuous participation assessment.

Methods

This study proposes a novel approach for estimating ALP during upper-limb robot-aided rehabilitation by leveraging machine learning within a multimodal framework. The system integrates pressure sensing at the human-robot interface and muscle activity monitoring to provide a more comprehensive assessment of user participation. The estimated ALP is used to dynamically adapt task execution time, enabling an adaptive ALP-driven impedance control strategy. The proposed approach was tested in a laboratory setting using a collaborative robot equipped with the sensorized interface. A comparative analysis was conducted against a conventional impedance controller, commonly used in robot-aided rehabilitation scenarios.

Results

The results demonstrated that participants using the ALP-driven impedance control exhibited significantly higher positive mechanical work and greater muscle activation compared to the control group. Additionally, subjective feedback indicated increased engagement and confidence when interacting with the adaptive system.

Discussion

Closing the robot's control loop by adapting to ALP effectively enhanced human-robot interaction and motivated participants to engage more actively in their therapy. These findings suggest that ALP-driven control strategies may improve user involvement in robot-assisted rehabilitation, warranting further investigation in clinically relevant settings.