bluuebunny/crossref_metadata_2025 huggingface dataset:
Method for laparoscopic transgastral resection for mesenchimal gastric tumors
Authors: Kamalov A. K. , Ryabov A. B. , Khomyakov V. M. , Volchenko N. N. , Kolobaev I. V. , Kostrygin A. K. , Aksenov S. A.
Published: March 2022

The purpose of the study was to evaluate the efficacy and safety of laparoscopic transgastric resection for mesenchymal tumors of the proximal stomach.

Material and Methods. A retrospective-prospective study was carried out. Surgical techniques of laparoscopic transgastric resection and the history of the development of this surgical method were described in detail. A total of 11 laparoscopic transgastric resections were performed. The course of the postoperative period and the postoperative management of patients were described. The immediate and long-term results of surgical treatment and the quality of life of patients were presented.

Results. The assessment of the quality of life of patients after surgery showed that there were no cases of gastroesophageal reflux disease compared to proximal subtotal resection of the stomach or endoscopic tunnel resection. All patients underwent radical resection. In our study, we did not encounter cases of conversion of the surgical approach, as well as serious postoperative complications (Clavien–Dindo>III ). The analysis of long-term treatment outcomes showed that there were no cases of recurrence or disease progression. All patients are alive and followed up.

Conclusion. This technique is fully justified, with careful selection of patients and compliance with all the rules of surgical oncology. Transgastric resection of gastric mesenchymal tumors located in the region of the cardioesophageal junction is a justified and safe technique. Surgery is performed under clear visual control, EGDS is not required to detect the tumor. This method allows the reduction of the frequency of contamination of the gastric flora into the abdominal cavity as well as the reduction of the wound area of the anterior abdominal wall.
Heat stress stimulates colon cancer cells to secret specific population of extracellular nanovesicles enriched by HSP70 and microRNAs
Authors: Nazarova I. V. , Zabegina L. M. , Nikiforova N. S. , Slusarenko M. A. , Sidina E. I. , Zhakhov A. V. , Ishchenko A. M. , Margulis B. A. , Guzhova I. V. , Malek A. V.
Published: March 2022

Background. Heat stress (HS) induces the cellular secretion of heat shock proteins (HSP ) and extracellular nanovesicles (ENVs). The biological link between these phenomena is poorly understood. In the case of colorectal cancer (CRC) cells, the secretion of HSP s and ENV may be involved in the clinical response to intraperitoneal therapy of peritoneal carcinomatosis.

Material and Methods. Established colon cancer cell lines COLO 320, HCT 116, HT29 and DLD 1 were used. ENVs were isolated from culture media by differential ultra-centrifugation and analyzed by dynamic light scattering, nanoparticle tracking analysis, atomic force microscopy and flow cytometry. Super-paramagnetic particles (SPMP ) covered by antibodies to the membrane form of Hsp70 were used for isolation and quantification of Hsp70(+) ENVs. Vesicular microRNA was assayed by RT-qPC R.

Results. HS induces the secretion of ENVs by CRC cells, the resistance to HS correlates with the activity of HS-induced ENVs secretion. HS induces the secretion of a specific population of ENVs enriched by membrane form Hsp70 (mHsp70). The microRNA content of mHsp70(+) ENVs has qualitative and quantitative features. The concentration of miR-126-3p, -181-5p, -155-5p, -223 is increased in mHSP 70(+) ENVs secreted by three CRC cell lines.

Conclusion. HS induces the secretion of mHSP 70(+) ENVs by CRC cells. This phenomenon may be involved in a clinical response to intraperitoneal chemo-hyperthermic perfusion therapy of peritoneal carcinomatosis.
Establishment of an orthotopic tumor model in the mammary gland of BALB/C nude mice using human breast cancer MCF-7 cells and their VDAC-deficient derivatives
Authors: Mndlyan E. Yu. , Semushina S. G. , Rzhevsky D. I. , Novikova N. I. , Kalabina E. A. , Komkov D. S. , Maslennikova A. Yu. , Murashev A. N. , Holmuhamedov E. L.
Published: March 2022

Purpose to study the tumor-forming activity of wild-type MC F-7 cells carrying a full set of porins (VDAC 1, VDAC 2, VDAC 3), as well as their genetically modified cells, from which one of the isoforms was removed (MC F-7 VDAC 1 KO, MC F-7 VDAC 2 KO, MC F -7 VDAC 3 KO).

Material and Methods. The study was aimed at establishing of an animal model of orthotopic tumors in the mammary gland of immunodeficient BAL B/c nude mice by implanting a suspension of human breast cancer cells (MC F-7) and derivatives of these cells generated by targeted knockout of one of the selected mitochondrial porin isoforms (VDAC 1, VDAC 2 or VDAC 3). Suspensions of either wild-type MC F-7 cell lines containing all three porin isoforms (VDAC 1, VDAC 2 and VDAC 3) or their VDAC -deficient derivatives (MC F-7 VDAC 1 KO, MC F-7 VDAC 2 KO and MC F-7 VDAC 3 KO) were injected into mammary fat pads of BAL B/c nude mice at a dose of 4x106 cells per injection. A pathomorphological analysis of the place of implantation of tumor cells, the tumor itself, as well as the organs of the abdominal and thoracic cavity was carried out.

Results. The study shows the feasibility of successful creation of orthotopic tumors in the adipose tissue of immunodeficient BAL B/c nude mice with MC F-7 human breast cancer epithelial cells containing a complete set of mitochondrial porin isoforms and their VDAC -deficient derivatives. The tumor-forming activity of the implanted cells was shown to correlate with their cytotoxic effect on the internal organs of animals. Pathological analysis showed that all implanted cell cultures, such as MC F-7 WT, MC F-7 VDAC 2 KO and MC F-7 VDAC 3 KO, except for MC F-7 VDAC 1 KO cells, which did not form tumors, caused pathological changes in the lungs, liver and spleen, as well as the presence of other tumor-like lesions.

Conclusion. The data obtained will be used to optimize the injection volume and cell number, as well as to refine the dynamics of tumor growth, suitable for studying the effect of anticancer drugs on tumors formed by human breast cancer cells (MC F-7) and its genetically modified VDAC -deficient derivatives.
Combination treatmnet of breast cancer patients during the COVID-19 pandemic
Authors: Kaprin A. D. , Zakiryakhodzhaev A. D. , Bosieva A. R. , Samsonov Yu. V. , Kostin A. A.
Published: March 2022

The aim of the study was to analyze the most significant studies representing the basic principles of diagnosis and treatment of patients with breast cancer (BC) during the CO VID -19 pandemic.

Material and Methods. The search for relevant sources was carried out in PubMed, Cochrane Library, Web of Science systems, publications for 2019–2020 were studied, 48 of which were used to write this review.

Results. During the CO VID -19 pandemic, it is necessary to suspend screening examinations for a certain period of time; patients with early and metastatic breast cancer should be transferred to outpatient treatment in the LU s located in their place of residence. Examinations and consultations of patients undergoing hormone therapy should be postponed or carried out using telemedicine technologies. Treatment of breast cancer patients during a pandemic should be carried out according to clinical guidelines and protocols, but minimizing the number of visits to the hospitals.

Conclusion. The pandemic of the novel coronavirus infection (CO VID -19) is a serious problem for healthcare and professionals around the world. All treatment decisions must be based on risks and benefits in the context of each stage of the pandemic, on an individual basis and taking into account the preferences of patients.
MODERN ADVANCED ARTIFICIAL INTELLIGENCE FOR SMART MEDICINE
Authors: Kolesnichenko O. Yu. , Martynov A. V. , Pulit V. V. , Kolesnichenko Yu. Yu. , Shakirov V. V. , Mazelis L. S. , Varlamov O. O. , Minushkina L. O. , Sotnik A. Yu. , Zhilina T. N. , Dorofeev V. P. , Smorodin G. N. , Zhaparov M. K.
Published: March 2022

Artificial Intelligence is no longer just the topic of discussion. Today this technology is mostly based on Artificial Neural Networks. Pavlov Principle formulated by W.L. Dunin-Barkowski is used for their training. Mathematics compared Pavlov's doctrine with Deep Reinforcement Learning. AI technologies are divided into Computer Vision, images recognition and generation; Speech Recognition and Synthesis; Natural Language Processing; Graph Logic AI, MIVAR logic technology. All of this separately is Narrow AI. Artificial General Intelligence, equal to human, hasn’t been created yet. AGI should include all mentioned technologies. Given social and linguistic nature of the intelligence emergence, developers are paying attention to NLP algorithms and multi-agent environment. Simultaneously with the development of neural networks, adversary attacks emerged, which using the same learning mechanism force a trained neural network to make mistakes. This fact calls in question the future of neural networks in medicine. Big Data and data sets are the environment for AI. European experts have already begun to regulate Big Data for safe Health Care and drugs creation. Despite the difficulties and lack of clear rules, AI is actively being introduced into the private medicine. Due to AI the three new business models have already been created.
Chemometric Evaluation of Poly(3-hexylthiophene) Electrochemical Aging Path as a Function of Electrochemical Synthesis Variables
Authors: Gonçalves Roger , Pereira Ernesto
Published: March 2022

Conductive polymers are versatile materials that can be applied in many different technology fields, especially green energy. They have several advantages, such as easy synthesis, low density, and cost. However, its electric conduction property is also related to material aging with great loss of their characteristics, limiting their applicability. The in-depth study of electrochemical aging can provide useful information for new strategies to overcome this problem. Thus, this work describes the use of factorial design to evaluate the influence of some synthesis variables on the aging of poly(3-hexylthiophene): electrolyte and monomer concentration and water in the synthesis of non-aqueous solution. For this, the properties of the films were evaluated by cyclic voltammetry, electrochemical impedance spectroscopy, and scanning electron microscopy. The accelerated electrochemical aging was performed by applying a potential higher than the superoxidation potential for 20 min steps. It was possible to identify two extreme cases, the conventionally synthesized polymer aged more, while the polymer obtained with the three altered parameters suffered fewer aging effects. It was possible to identify a range of different aging pathways among these. The mechanical stress caused by the several oxidation/reduction cycles of the material aligned to the increasing loss of polymer properties, potentiates aging.
FESTAR E APRENDER
Authors: Matias da Silveira Lucas , De Mattos Motta Flavia
Published: March 2022

Este estudo teve como propósito investigar as pedagogias presentes nas práticas sociais relacionadas à casa noturna, denominada 1007, localizada no município de Florianópolis - SC. A balada surgiu no ano de 2009 começando a funcionar como boate e prostíbulo ao mesmo tempo. Desta forma, a casa incorpora valores e uma cultura que compartilha com seus frequentadores através de pedagogias diversas, criando assim um ethos do 1007. Este artigo se organiza da seguinte maneira: como o ambiente se estrutura, expondo todos os ambientes e espaços; caracterização do público frequentador; e a partir disso, realizou-se uma análise de como estes ambientes, estabelecimento e público produzem pedagogias, utilizando-se de discursos, performances, a cultura e valores operantes no 1007, resultando em construção de corpo, gênero e sexualidade no espaço em questão, envolvendo principalmente a comunidade LGBT+. A pesquisa foi realizada, em 2015, utilizando método da etnografia, combinada a um questionário online realizado com frequentadores da balada e uma entrevista semiestruturada com o proprietário da casa noturna e também com funcionários.
JORNALISMO E TRATAMENTO DE GÊNERO
Authors: Gracik Tome Taissa , Borges Rosana Maria Ribeiro
Published: March 2022

O trabalho objetivou analisar a forma como os gêneros masculino e feminino apareceram nas notícias do portal jornalístico G1 Goiás entre março e abril de 2021. A temática se propõe a entender, por meio de uma pesquisa qualitativa, a influência de uma sociedade patriarcal no fazer jornalístico e a forma como ambos os gêneros citados são tratados nas abordagens do Portal. Entende-se que a reflexão acerca da forma como homens e mulheres são representados através do jornalismo infere em uma percepção do meio em que se está inserido e, por isso, a pesquisa se faz significativa tanto em meios acadêmicos quanto fora deles. Para tanto, foi necessário a definição e debate dos conceitos de gênero e as relações sociais que os envolvem, além do fazer jornalístico e do próprio jornalismo, que foi complementado com as ideias de notícia e reportagem, que envolvem diretamente o objeto deste estudo. Ademais, através do estudo de caso do Portal, viabilizado pelo levantamento bibliográfico, pela coleta de dados e pela análise de conteúdo, foi possível confirmar a hipótese de que raízes sociais de um machismo estrutural influenciam na forma como o jornalismo acontece e no modo como homens e mulheres são representados pelo G1 Goiás.
EXCLUSÃO COMO DISPOSITIVO
Authors: Pinheiro Ramos de Souza Fábio , Sepulveda Denize
Published: March 2022

Esse artigo resulta de uma pesquisa de mestrado e objetivou desenlvover uma análise sobre as articulações que envolvem a exclusão social no processo de expulsão escolar de mulheres trans e travestis. Através de uma revisão bibliográfica sobre a temática foi possível realizar uma construção de entendimento entre os conceitos de “evasão” e “expulsão”  e compreender como a exclusão social funciona como um dispositivo chave da resultante em questão. A expulsão escolar apresentou-se como um problema que muitas vezes pode ser entendido como fator generalista de “desistência” do percurso escolar. É importanta destacar, também, que a formação desse processo de exclusão pode ser compreendida como multiplas e complementares. No entanto, observado as suas caracteríticas específicas como o recorte de gênero,  a exclusão social se mostra como mecanismo central para compreendermos a expulsão.  Desse modo, entendendo o curriculos escolar como base para compreender o que acontece nas jornadas escolares trans, foi possível  destrinchar as nuances que corroboram para que esse problema social perdure nas escolas brasileiras.
RASTREIA-TE A TI MESMO
Authors: Martins dos Santos Flávia , Lyggon de Sousa Oliveira Mayllon
Published: March 2022

Vivemos em contexto biopolítico em que somos atravessados o tempo todo por riscos eminentes, o que caracteriza uma sociedade do risco. Essa dinâmica inaugura uma experiência de vida pautada na vigilância, não mais do Estado ou das instituições totais, mas de cada pessoa que é empreendedora de si mesma, ou seja, responsável e responsabilizada pelos riscos que está disposta a correr e em que condições. Isso inaugura uma vivência em que novos dispositivos tecnológicos, como os smartphones e smartwatches, passam a interferir nas formas de viver e experienciar o mundo, sobretudo no que diz respeito à própria saúde, agora pautada também em práticas de self-tracking ou automonitoramento. Dito isso, o objetivo desse trabalho é analisar, por meio das análises das práticas discursivas e produção de sentido, os repertórios sobre o corpo saudável nas páginas do aplicativo Saúde e do Apple Watch da marca Apple e como estes estimulam as pessoas a gerir seus corpos e riscos por meio de uma chave de ação neoliberal em que cada pessoa é responsável rastrear o próprio corpo e então tomar decisões que as deixe ou mantenha saudável. O que se conclui é que novas configurações de saúde ligadas às tecnologias são diretamente pautadas pela lógica dos riscos e do consumo, produzindo assim novas demandas corporais, novas práticas biopolíticas e novos parâmetros para refletir sobre a corporeidade contemporânea.
GATTACA, UMA EXPERIÊNCIA GENÉTICA
Authors: Santos Maria Edivania Alves dos , Mezzaroba Cristiano , Zoboli Fabio
Published: March 2022

Neste ensaio, trazemos reflexões possíveis em relação ao filme “Gattaca, Uma experiência genética” (filme norte-americano, produzido em 1997, dirigido por Andrew Niccol), articulando, a partir da obra fílmica, questões do contemporâneo que envolvem o corpo moderno, identidade social e estigma, tendo como objetivo principal demonstrar a potencialidade do cinema enquanto dispositivo pedagógico e cultural para promover reflexões sobre as questões relacionadas ao estigma. Consideramos que produtos artísticos e culturais, a exemplo dos filmes, configuram-se como elementos necessários não apenas a ilustrar temáticas complexas, como as questões pertinentes às múltiplas identidades humanas e às marcas sociais inscritas nos corpos, que geram e explicitam estigmas sociais, como também possibilitam exemplificações, problematizações, reflexões e diálogos no campo educacional e formativo. O ensaio defende a necessidade de mobilizar mais modos de vida por meio da arte no contexto educacional, considerando os múltiplos e diversos olhares das humanidades em um trabalho em conjunto que considere a perspectiva do audiovisual na educação/formação, permitindo ampliar os olhares políticos e estéticos sobre o corpo no contemporâneo.
Matematik Eğitiminde Teknoloji Odaklı Gerçekleştirilen bir Proje Kapsamında Matematik Öğretmenlerinin Teknolojiye Yönelik Görüş ve Farkındalıklarının İncelenmesi
Authors: BOZKURT Gülay
Published: March 2022

Bu çalışmanın amacı, Matematik Eğitiminde Yenilikçi Teknoloji Uygulamaları projesi kapsamında ortaokul matematik öğretmenlerinin teknoloji kullanımı konusunda görüş ve farkındalıklarının nasıl geliştiğini/değiştiğini incelemektir. Valsiner’in alan teorisi bu çalışmanın kuramsal çerçevesi olarak belirlenmiştir. Araştırma, nitel araştırma paradigması benimsenerek durum çalışması ile desenlenmiştir. Araştırmanın katılımcıları Türkiye’nin farklı bölgelerinden seçilmiş Milli Eğitim Bakanlığı’na bağlı devlet okullarında çalışan 22 ortaokul matematik öğretmenidir. Proje öncesi ve sonrasında katılımcılar ile yapılan odak grup görüşme kayıtları çalışmanın veri grubunu oluşturmaktadır. Benimsenen çerçeve kapsamında, matematik öğretmenlerinin söylemlerinin analizinde özellikle serbest hareket alanları ve desteklenen eylem alanları belirlenmiştir. Çalışmanın bulguları, proje eğitimlerinden önce öğretmenlerin teknoloji kullanımı bağlamında serbest hareket alanlarının çok kısıtlı olduğunu, bu öğretmenlerin çoğunlukla teknolojiyi statik olarak kullandıklarını ve öğrencilerinin eylemlerini kağıtkalem ortamından farklı olarak destekleyemediklerini göstermektedir. Fakat eğitimlerden sonra öğretmenler, serbest hareket alanlarının genişlediğini, özellikle ücretsiz ve kolay erişim sağlayabilecekleri birçok yazılımın müfredat kazanımları doğrultusunda nasıl kullanabileceklerini öğrendiklerini ve desteklenen eylem alanlarının da genişlediğini ifade etmişlerdir.
Ortaokul Öğrencilerinin Çember Konusundaki Kavramsal Anlamalarının İncelenmesi: 5E Öğrenme Modeli ile Ters Yüz Edilmiş Sınıf Yaklaşımı
Authors: ÖZCAN Şule , DEMİR Mehmet , AKSU Nazlı , URHAN Selin , ZENGİN Yılmaz
Published: March 2022

Bu çalışmada, sorgulamaya dayalı 5E öğrenme modeli ile ters yüz edilmiş sınıf yaklaşımı bağlamında ortaokul öğrencilerinin çember konusundaki kavramsal anlamaları temsil dönüşümü açısından incelenmektedir. Araştırmanın katılımcılarını bir devlet okulunda yedinci sınıfta öğrenimine devam eden altı öğrenci oluşturmaktadır. Çalışmada nitel araştırma yöntemlerinden öğretim deneyi yöntemi benimsenmiştir. Veri toplama aracı olarak araştırmacıların hazırladığı matematiksel etkinlikler, öğrencilerin oluşturmuş olduğu GeoGebra dosyaları, uygulama sırasında alınan görüntü ve ses kayıtları ve uygulama sonrası yapılan etkinlik temelli görüşmeler kullanılmıştır. Öğrencilerin kavramsal anlamalarının ayrıntılı incelenmesi için veriler söylem analizi yoluyla analiz edilmiştir. Araştırmanın sonucunda, giriş aşamasının sınıf dışı süreci için hazırlanan videonun öğrencilerin çemberin ve çember parçasının uzunluğuna ilişkin ön bilgilerini hatırlamasını; açıklama aşamasının sınıf dışı süreci için hazırlanan videoların ise öğrencilerin konuyu tekrar etmesini sağladığı belirlenmiştir. Değerlendirme aşamasının sınıf içi sürecinde öğrencilerin problem durumuna çözüm üretirken en az iki temsil sistemi arasında dönüşüm yapabildiği görülmüştür. Çalışmada sorgulamaya dayalı 5E öğrenme modeli ile ters yüz edilmiş sınıf yaklaşımı kapsamında uygulanan GeoGebra destekli etkinliklerde öğrencilerin farklı temsil sistemlerini kullanarak temsiller arası dönüşüm gerçekleştirmelerinin kavramsal anlama süreçlerine katkı sağladığı belirlenmiştir.
On the Issue of Analyzing and Optimizing the Salary Budget of Professional Hockey Clubs
Authors: Kurochkina I. P. , Mamatova L. A. , Shuvalova E. B. , Malysheva N. A.
Published: March 2022

The purpose of the study. The aim of the study is to use the methods of correlation-regression analysis as a tool to determine the fair share of a professional hockey player’s salary in the total salary budget of a hockey club. In modern conditions of functioning of professional hockey clubs, in which the total costs of the players’ salaries are strictly regulated by the “salary cap”, the availability of a tool that allows an objective assessment of the player’s contribution to the overall team result can increase the effectiveness of management decisions. In this paper, a regression model is proposed that allows us to determine the impact of individual characteristics of players, using the example of team defensemen, on the share of their wages in the salary cap.Materials and methods. To select a multiple regression model, the statistical indicators of the defensemen of the National Hockey League in the 2018-2019 season were analyzed. At the substantive stage to design a model, a list of those statistical indicators was determined that, in our opinion, allow us to conclude above that a particular player is useful for the team, and also meet the requirements for factors to be included in the multiple linear regression model (quantitative assessment, close relationship with the result, lack of multicollinearity). In order to obtain the highest quality regression model, a posteriori approach was used in the selection of factors that should be included in the final version of the regression model. As a result of the step-by-step selection of factors, the factors were excluded from the model, t-statistics’ values of which made it possible to draw a conclusion on their statistical insignificance.Results. As a result, a statistically significant model was obtained that describes the dependence of the share of wages in the salary cap of the 2018-2019 season. Comparing the salary shares predicted using the obtained model and their actual values, it was possible to determine the most overrated and underestimated defensemen of the National Hockey League in the 2018-2019 season.Conclusion. The proposed regression model is an example of how econometric methods combined with hockey statistics allow us to quantify the pricing patterns of a professional hockey player’s contract. In our opinion, the obtained model of multiple linear regression is an affordable tool that allows us to give an adequate assessment of the value of a professional hockey player’s contract and help in solving one of the most urgent tasks in sports management – the formation of a competitive team in the presence of a salary cap.
Cognitive Modeling of the Impact of Funding to Educational Institutions on the Innovative Activity of Organizations
Authors: Bryzgalov A. A.
Published: March 2022

The purpose of research is to design a cognitive model for determining the degree of influence of targeted funding in educational programs on the innovative activity of an enterprise in different business conditions. As a tool for cognitive modeling, it is proposed to use the tools for constructing a cognitive map that allows analyzing different options of financing scenarios, which are alternatives to impulse modeling in the form of financing in a certain set of factors by introducing perturbations to the vertices of the cognitive map. The main reason for the study is that when creating new products or services for an organization, it is important to constantly increase their market share based on changes in the strategy of innovative activity of the enterprise, which is largely determined by the level of qualification of the workforce. The novelty of the research lies in the use of tools for constructing and using a cognitive map to solve the problem of substantiating the most preferred variant of a set of initial factors to achieve the required maximum values of the target indicators.The research methods are heuristic in nature, aimed at finding such a set of factors that will lead to a given change in the target factor. In order to obtain the final result of changing the target factor, impulse modeling is used, which is carried out by introducing influences into the selected set of vertices of the cognitive map, and in order to find the best set, scenario modeling is used aimed at forming various alternatives. The proposed materials and methods of cognitive modeling are based on the cognitive map, presented in the work of R.Karaev and others [4].Results. This article shows how organizations develop their innovative activities in production processes. This development process is associated with the interaction of enterprises and educational institutions, which is expressed in the joint training of specialists in the required field. To display the interrelation of factors influencing innovation activity in production processes, a model is proposed, which is reflected in the cognitive map of enterprise strategy management expanded by the author. As a result of cognitive modeling according to certain scenarios, recommendations are formed for decision makers on the choice of an innovative development strategy of an enterprise aimed at increasing the company’s market share.Conclusion. The conducted modeling and analysis of the results confirm that innovative activity allows to increase the market share and reduce the price of the company’s products due to investments in educational institutions. In addition to the required changes in the target factors, the proposed funding has a positive effect on other factors reflected in the cognitive map. As a result, the constructed cognitive map can reveal the factors determining the need for investment in educational institutions by organizations, which will increase their innovative activity and economic efficiency.
A Review on the Neuroprotective Effect of Berberine against Chemotherapy- induced Cognitive Impairment
Authors: Sahu Kuleshwar , Singh Sukhdev , Devi Bhawna , Singh Charan , Singh Arti
Published: March 2022

Chemobrain is one of the major side effects of chemotherapy; despite increased research, the mechanisms underlying chemotherapy-induced cognitive changes remain unknown. Several pos-sibly important candidate mechanisms have been identified and will be studied further in the future. Chemobrain is characterized by memory loss, cognitive impairment, difficulty in language, concen-tration, acceleration, and learning. The major characteristic of chemobrain is oxidative stress, mito-chondrial dysfunction, immune dysregulation, hormonal alteration, white matter abnormalities, and DNA damage. Berberine (BBR) is an isoquinoline alkaloid extracted from various berberine species. BBR is a small chemical that easily passes the blood-brain barrier (BBB), making it useful for treat-ing neurodegenerative diseases. Many studies on the pharmacology of BBR have been reported in the past. Furthermore, several clinical and experimental research indicates that BBR has a variety of pharmacological effects. So, in this review, we explore the pathogenesis of chemobrain and the neu-roprotective potential of BBR against chemobrain. We also introduced the therapeutic role of BBR in various neurodegenerative and neurological diseases such as Alzheimer's, Parkinson's disease, mental depression, schizophrenia, anxiety, and also some stroke.
Changing Characteristics of Patients Living with HIV/AIDS After the
COVID-19 Pandemic in Turkey
Authors: Karaosmanoglu Hayat Kumbasar , Mete Birgul , Gunduz Alper , Sevgi Dilek Yildiz , Aydin Ozlem Altuntas , Dokmetas Ilyas , Tabak Fehmi
Published: March 2022

Aims:

The COVID-19 pandemic has substantially changed lives and presented several barriers
to health services. HIV care continuum needs a high rate of diagnosis, effective treatment, and
sustained suppression of viral replication. The COVID-19 pandemic has affected these three steps of
HIV care. This study investigated the characteristics of newly diagnosed patients living with
HIV/AIDS (PLWH) during the COVID pandemic and compared them with those before the pandemic.

Methods:

All newly diagnosed patients in three HIV healthcare centers, in Istanbul, Turkey, were
included in the study. The pandemic period included April 1, 2020, to April 1, 2021, and the prepandemic
period included March 1, 2019, to March 1, 2020.

Results:

756 patients were diagnosed with HIV/AIDS. In the pandemic period, this figure was 58%
less: 315. Patients in the pre-pandemic and pandemic period had comparable age and gender distributions.
PLWH diagnosed in the pandemic period had higher rates of low CD4 cells: low CD4 (<350
cells /mm3) was measured in 243 (36.4%) patients in the pre-pandemic period, while it was done in
126 (47.9%) in the pandemic period (p<0.01). Also, the distribution of CD4 cells was significantly different
between periods: In the pandemic period, CD4 cell distribution significantly skewed to lower
CD4 categories. Symptomatic patient rates and AIDS-defining disorder rates among symptomatic patients
were comparable. Viral loads were not significantly different in the two periods.

Conclusion:

A low number of newly diagnosed PLWH can be explained by less HIV testing, less
admission to health care, or an actual decrease of HIV prevalence during the pandemic. Sexual behaviors
may have changed during the COVID-19 pandemic, leading to HIV transmission restriction.
Lower CD4 counts among the newly diagnosed PLWH suggest that admittance to health care is late
and a significant portion of PLWH remain undiagnosed.
Pharmacological Significance of Synthetic Bioactive Thiazole Derivatives
Authors: Amin Andleeb , Qadir Tanzeela , Salhotra Alka , Sharma Praveen Kumar , Jeelani Ishtiaq , Abe Hitoshi
Published: March 2022

Thiazole and the related nuclei constitute one of the most significant moieties in the
extensively emerging domain of heterocyclic compounds. The versatile nature of the thiazole nucleus
can be determined as it is present in natural products like vitamin B1. Furthermore, its derivatives
exhibit diverse biological activities, including antimicrobial, anticancer, antihistaminic, antioxidant,
etc. They have also emerged as potent CNS agents and are primarily used in the treatment
of various CNS disorders. The structure-activity relationship of various amine derivatives of ethylated
thiazole demonstrates their use as potential agents in the treatment of melanoma, pigmentation
as well as solar elastosis. Thiazole fused with different heterocyclic systems results in many novel
derivatives with higher therapeutic activity. Benzothiazole and Thiazolopyrimidine have a distinct
position in this regard. This review focuses on the central role of thiazole and its derivatives in
current drug design, covering a broad spectrum of pharmacological activities associated with them.
Growth Hormone/Insulin-like Growth Factor 1 Axis Associated with
Modifier Factors in Children with Sickle Cell Anemia
Authors: Costa-Júnior Domício Antônio da , Santos Ana Paula Pinho , da Silva Célia Maria , Velloso-Rodrigues Cibele
Published: March 2022

Background:

Sickle cell anemia is a disease that develops episodes of acute pain and multiple organ dysfunction that can affect the growth hormone/insulin-like growth factor 1 (GH/IGF-1) axis. The severity of sickle cell anemia is influenced by modifying factors, such as levels of fetal hemoglobin (HbF), the co-inheritance of alpha-thalassemia, or treatment with hydroxyurea.

Methods:

This cross-sectional study in children with sickle cell anemia evaluated bone age (BA), adult height prediction (AHP) using BA, a target height (TH) calculated as the mean SDS of the parents, and laboratory parameters. Children were grouped according to serum levels of HbF, co-inheritance of alpha-thalassemia, and hydroxyurea therapy.

Results:

The mean age of the 39 children was 8.2 ± 2.2 years old. The average height was -0.75 ± 0.30 SDS, and 10.3% (4/39) had short stature. Adjusted levels of IGF-1 or IGFBP-3 were significantly higher in children with sickle cell anemia on hydroxyurea treatment, in children with HbF levels >10%, and in those without alpha-thalassemia. Using SDS, the growth potential of children with sickle cell anemia in relation to their parents calculated by the difference between AHP and TH as well as the difference between children’s height and their TH, were lower in children with co-inheritance of alpha-thalassemia.

Conclusion:

The study showed an association between modifying factors and the GH/IGF-1 axis in children with sickle cell anemia. Additionally, the co-inheritance of alpha-thalassemia was associated with decreased height in these children when adjusted for their parents’ height.
Hemocyten van de honingbij (Apis mellifera), een babylonische spraakverwarring
Authors: Van Herzele C. , Nauwynck H. , de Graaf D.C.
Published: March 2022

Het afgelopen decennium werden er wereldwijd alarmerend hoge sterftecijfers bij honingbijen geregistreerd. Deze trend is problematisch omdat de bij een cruciale rol speelt als bestuiver in natuurlijke en agrarische ecosystemen. Deze problematiek wordt veroorzaakt door verschillende stressoren met de varroamijt (Varroa destructor) als belangrijkste. Onafhankelijk van de oorzaak is het eindresultaat echter hetzelfde: het immuunsysteem begeeft het waardoor de bij en bij uitbreiding het bijenvolk sterft. Om dit fenomeen te kunnen begrijpen, is het belangrijk een grondige kennis te bezitten van hun immuunsysteem. Deze is namelijk verantwoordelijk voor de bescherming van bij en bijenvolk tegen deze verschillende stressoren. Ondanks het grote belang van de bij en het huidige hoge aantal wetenschappelijke publicaties over honingbijen, is er nog maar weinig onderzoek naar hun cellulaire immuniteit verricht. In dit artikel worden de obstakels van het hemocytenonderzoek beschreven, zoals traumatische collectiemethoden, gebrek aan standaardisatie en onvoorzichtige extrapolatie (van insecten en leeftijden). Als laatste wordt een beknopt overzicht gegeven van de vermoedelijke hemocytentypes en hun functies. 
Sob as águas, respirar e resistir
Authors: Daré Paula Serafim
Published: March 2022

Em uma troca de mensagens da equipe da Self, falávamos da necessidade de 2022 chegar de mansinho, depois de uma travessia difícil, que ainda não terminou, marcada pela pandemia da Covid-19 e agravada por um quadro de desemprego, inflação e desgoverno do país.

O ano de 2022, no entanto, chegou com enchentes na Bahia, Minas Gerais e Petrópolis, região serrana do Rio de Janeiro, com um novo surto de COVID-19 e da gripe influenza e a queda de uma gigantesca rocha em Capitólio (MG). No plano internacional, a Rússia entra em guerra contra a Ucrânia, revivendo lembranças difíceis da última grande guerra mundial.
Evidence for Continuing Professional Development and Recency of Practice Standards for Regulated Health Professionals in Australia: Protocol for a Systematic Review
Authors: Main Penelope , Anderson Sarah
Published: March 2022

Background

Continuing professional development (CPD) and recency of practice (ROP) standards are components of health practitioner regulation in Australia. The CPD and ROP standards are currently under review, and an evidence base to assist the development of consistent standards is required. Preliminary searching was unable to find a recent systematic review of the literature to provide an evidence base to underpin the standards review.

Objective

This paper presents the protocol for a systematic review that aims to develop a current evidence base that will support the National Boards to develop more consistent, evidence-based, effective standards that are clear and easy to understand and operationalize.

Methods

Research questions were developed to support the planned review of CPD and ROP registration standards. Major databases and relevant journals were searched for articles published in English between 2015 and 2021, using key search terms based on previous unpublished reviews of the CPD and ROP registration standards. The quality of the articles retrieved will be assessed using an instrument suitable for use in the development of public policy. The findings will be published in a peer-reviewed journal.

Results

In September 2021, our search strategy identified 18,002 studies for the CPD-related research questions after removal of duplicates. Of these, 509 records were screened based on their title, and 66 full-text articles were assessed for eligibility based on their abstract, of which 31 met the inclusion criteria. A further 291 articles were identified as relevant to the ROP research questions. Of these, 87 records were screened based on their title, and 46 full-text articles were assessed for eligibility based on their abstract, of which 8 studies met our inclusion criteria.

Conclusions

This protocol outlines the scope and methodology that will be used to conduct a systematic review of evidence for CPD and ROP and inform a review of the standards for regulated health professionals in Australia. Previous research has shown that while CPD improves practitioner knowledge, the link to public safety is unclear. While there has been a greater focus on maintenance of certification and other quality assurance activities over the past 10 years, there remains great variability in CPD requirements across both professions and jurisdictions. ROP was found to be a poorly researched area with most research concentrating on medical practitioners, nurses, and midwives and no clear consensus about the optimal time period after which retraining or an assessment of competence should be introduced. As the CPD and ROP standards are currently under review, it is timely that a review of current evidence be undertaken.

International Registered Report Identifier (IRRID)

DERR1-10.2196/28625
Canadian resources on cannabis use and fertility, pregnancy, and lactation: A Scoping Review (Preprint)
Authors: Sharif Ayni , Bombay Kira , Murphy Malia S. Q. , Murray Rebecca K. , Sikora Lindsey , Cobey Kelly D. , Corsi Daniel
Published: March 2022

BACKGROUND

Cannabis use among reproductive-aged Canadians is increasing, but our understanding of its impacts on fertility, pregnancy, and breastmilk is still evolving. Despite the availability of many online resources, informed-decision making and patient counselling are challenging for expectant families and providers alike.

OBJECTIVE

To conduct a scoping review of publicly available online Canadian resources providing information on the effects of cannabis on fertility, pregnancy, and breastmilk.

METHODS

We systematically searched eight databases between 1-Jan-2010 and 30-Nov-2020 and webpages of 71 Canadian obstetrical, government, and public health organizations. English resources discussing the effects of cannabis on fertility, pregnancy, breastfeeding, or the exposed fetus/infant were included. Epidemiological characteristics, readability, and content information were extracted and summarized.

RESULTS

A total of 183 met our inclusion criteria. Resources included content for public audiences (89.1%) and healthcare providers (n=31, 16.9%). The majority (68.3%) were written at a 10+ reading-grade level, and few (3.8%) were available in languages other than English or French. Common themes included citing a need for more research into the effects of cannabis on reproductive health and recommending that patients avoid or discontinue use. Although resources for providers were consistent in recommending patient counselling, resources targeting the public were less likely to encourage seeking advice from healthcare providers (n=23, 14.1%).

CONCLUSIONS

Canadian resources consistently identify that there is no known safe amount of cannabis that can be consumed in the context of fertility, pregnancy, and breastfeeding. Areas of improvement include increasing readability, language accessibility, and encouraging bidirectional communication between healthcare providers and patients.

INTERNATIONAL REGISTERED REPORT

RR2-10.1136/bmjopen-2020-045006
The Color Purple: Reflections on The Second Sex and Gender Issues
Authors: Dasgupta Koyel
Published: March 2022

In this paper, we shall look at Alice Walker’s The Color Purple in the light of Simone De Beauvoir’s The Second Sex and analyse Celie’s transformation from the ‘Other’ in De Beauvoir’s terms to ‘Self’ in the course of the novel and how she grows up to speak for herself from being apparently silent under the oppression of her step-father and then her husband. We shall however question as to whether her ‘voicelessness’ can be considered equivalent to silence as she never stops from recording her experiences and emotions in her diary which is also a mode of expression. We shall also compare and contrast Celie, Shug, Sofia and Nettie in the light of The Second Sex. We shall also evaluate how Alice Walker has portrayed Celie’s liberation from the domination of the men through the lesbian relationship between Shug Avery and try and briefly observe Walker’s representation of the ‘Black Lesbian’. Simone de Beauvoir has talked how women have been considered below man for centuries but we shall question in the light of the novel that how can we differentiate between the two genders and can that with which we are born in between the two legs- a phallus or a vagina be the sole criteria to determine who we are, what we should do, what we should wear and how we should behave or in other words can the phallus or the vagina only define our gender?
БУДУЩЕЕ СЕТЕЙ FTTX − ПРОКЛАДКА В МИКРОТРУБКАХ
Authors: Попов С.
Published: March 2022

Maillefer совместно с материнской компанией Davis-Standard, LLC, одним из мировых лидеров в сфере производства оборудования и решений для переработки полимеров, приняли участие в 24-й Международной специализированной выставке пластмасс и каучука interplastica 2022, состоявшейся в московском ВЦ "Экспоцентр" 25–28 января 2022 года. На данном событии Maillefer представляла в первую очередь свои решения и услуги для трубной промышленности, в том числе микротрубок, предназначенных для прокладки оптических кабелей и волокна c помощью технологии задувки.
"СВЯЗЬ-2022" − КРУПНЕЙШАЯ БИЗНЕС-ПЛОЩАДКА В СФЕРЕ ТЕЛЕКОММУНИКАЦИЙ И ИНФОРМАЦИОННЫХ ТЕХНОЛОГИЙ
Authors: Касаткина Е.
Published: March 2022

26−29 апреля, в привычные сроки, в московском центральном выставочном комплексе "Экспоцентр" на Красной Пресне состоится крупнейшее в году событие, посвященное ИКТ-технологиям − очередная "Российская неделя высоких технологий", представляющая собой межотраслевую платформу для создания и развития инфраструктуры цифровой экономики России. Якорным мероприятием РНВТ традиционно остается международная выставка "Связь", которая уже почти полвека является непременным местом "сверки часов" для профессионалов сферы информационных и коммуникационных технологий. О феномене устойчивости этого уникального события, его истории и дальнейшем развитии журналу рассказала руководитель Дирекции высокотехнологических выставок АО " Экспоцентр" Е.Т.Касаткина.
ВОЛОКОННО-ОПТИЧЕСКИЕ ТРАНСПОРТНЫЕ СЕТИ: ОБЕСПЕЧЕНИЕ КОНФИДЕНЦИАЛЬНОСТИ И БЕЗОПАСНОСТИ
Authors: Коган С.
Published: March 2022

Потребность в передаче больших объемов данных между центрами обработки данных, в обеспечении высокопроизводительных вычислительных процессов и работы критически важных для бизнеса приложений нарастает. Волоконно-оптические транспортные сети, особенно те, которые обеспечивают взаимодействие между несколькими сайтами с ЦОДами, должны поддерживать высокий уровень безопасности. Традиционно угрозы безопасности исходят от вредоносных программ или хакеров-любителей. Их целями чаще всего являются прибыль от продажи интеллектуальной собственности, финансовая информация и даже вымогательство. В статье рассматриваются технологии защиты данных, а также способы обеспечения безопасности волоконно-оптических транспортных сетей.
Некоторые особенности формирования структуры и свойств новых алюминиевых сплавов при аддитивном производстве
Authors: Рябов Д.К. , Грушин И.А. , Сеферян А.Г.
Published: March 2022

Представлены результаты исследований ряда алюминиевых сплавов различных систем легирования, получаемых по технологии СЛС, и проведен их сравнительный анализ с традиционными литейными и деформируемыми алюминиевыми сплавами.
INTERRELATIONSHIP BETWEEN WORK AND PRIVATE LIFE OF EMPLOYEES - CONFLICT OR BALANCE?
Authors: Mladenović Milica , Krstić Bojan
Published: March 2022

Contemporary companies consider work-life balance a crucial topic. Higher work pressure, longer working hours and more families with both working parents have made balancing work and private life even more difficult. The paper addresses this interrelation and highlights two research questions regarding the type of relationship (positive or negative) that exists between work and private life of employees. These questions are answered based on the analysis of various previously conducted empirical research studies. Findings reveal both negative and positive interrelationship between employees' work and private life. The contributions and conclusions of this paper can be extremely relevant for a company to comprehend how important the creation of work-life balance initiatives is for increasing job satisfaction of its managers and other employees, as well as for developing the reputation of a desirable employer.
SUSTAINABLE FINANCE AND BANKING: A CHALLENGE FOR REGULATORS AND A RISK MANAGEMENT SYSTEM
Authors: Jemović Mirjana , Radojičić Jelena
Published: March 2022

The key position of banks in the financial sector, as well as their indisputable role in financing economic development, have conditioned the need to consider their impact on the environment. The implementation of the concept of sustainability in banking has conditioned the transformation of banks in the direction of their greater corporate eco-efficiency and the development of banking products and services that contribute to sustainable development. Sustainable finance for banks is a source of new opportunities, but on the other hand, banks are more and more concerned about their exposure to environmental risk. Recognizing the impact of environmental risks on banks’ operations, central banks and supervisors are taking a number of initiatives to reduce the negative impact of these risks on banks’ operations, and, thus, financial stability. The paper aims to point out the challenges that sustainable banking has posed to regulators and the risk management system
THE IMPACT OF THE PANDEMIC COVID-19 ON HOSPITALITY INDUSTRY AND TOURISM WORKERS
Authors: Stoicea (Ignătescu) Dana-Maria
Published: March 2022

The contemporary Coronavirus pandemic (Covid-19) has led the world to a severe socio-economic crisis and psychological distress. It has distressed the economy, but the services sector, especially the hospitality industry, is seriously affected by it. This study investigates how this virus influences organizational confidence, job satisfaction, and increases employees' sense of insecurity and perceptions of being unemployed. We performed a comparative analysis of the main indicators in tourism in 2020 compared to the same period of 2019, referring to the data recorded internationally. Also, the research aimed to identify how much the hospitality sector is affected by the crisis produced by the Covid-19 pandemic. The results specify that perceived job insecurity interposes the fear of the economic crisis.