bluuebunny/crossref_metadata_2025 huggingface dataset:
Murder Motivated by Blood Feud: Features of the Subject of the Crime
Authors:   Institute of Philosophy and Law of the Ural Branch of the Russian Academy of Sciences, Korsakov Konstantin V.
Published: December 2021

This article focuses on the resolution of issues and difficulties legal professionals encounter when qualifying criminal acts under Item e.1 of Part 2 of Article 105 of the Criminal Code of the Russian Federation (Item e.1). The issues and difficulties appeared when the 1996 Criminal Code entered into force and still exist. They are associated with the absence of a legal definition of blood feud in the text of the Criminal Code and other federal statutes, and also with the fact that Decision No. 1 of the Plenum of the Supreme Court of the Russian Federation, On Judicial Practice in Murder Cases, of 27 January 1999, both in the previous and in the current versions, does not contain any comments and clarifications on the characteristics of Item e.1. The greatest difficulties in investigative and judicial practice appear when determining the subject of the given crime. For a long time, the question of what kind of subject of the crime - general or special - is the subject of the crime envisaged in Item e.1 (formerly Item k of Article 102 of the Criminal Code of the RSFSR) continues to be controversial and open in the Russian criminal law theory. The author of the article has made a comprehensive critical analysis of the points of view, opinions, and approaches available in the criminal law doctrine regarding the definition of the type of subject in Item e.1 - murder motivated by blood feud; this has an important qualification value and directly affects the legal assessment of the criminal act provided for in this item. The article presents and examines the doctrinal provisions, court decisions, and norms of criminal law in terms of determining the type of subject of murder motivated by blood feud. The author proposed, explained, and scientifically substantiated a uniform approach to the definition of the subject in Item e.1; this approach can order the Russian law enforcement practice and resolve all the problems. The author also formulated conclusions supported by arguments and reasons. The conclusions confirm the correctness of the scientific and legal approach, according to which the subject of the crime envisaged in Item e.1 is special and should belong to a group of population which cultivates the custom of blood feud.
Mechanisms of Discursive Influence in the Communicative Space of Convergent Radio
Authors:   Tomsk State Pedagogical University, Yermolenkina Larisa I.
Published: December 2021

The focus of the article is on the problem of the media influence of one of the hybrid forms of modern communication - convergent radio broadcasting on the Internet. The article considers the social network version of convergent radio broadcasting through popular Internet accounts. It is in this communicative space that the active and creative nature of the role of the addressee is manifested. The addressee constructs discourse in interactive communication when discussing topics (editorial posts) journalists initiate. The focus of the study is on the materials of three interactive sessions of the radio stations Echo of Moscow and Radio Mayak, which organized a discussion of news and journalistic texts. The methodology of the material analysis takes into account the institutional and personal aspects of the discursive practice of convergent radio. In the terms of the discursive approach, the article reveals the role of the contexts of the analog radio source (its format concept) and social network communication, which structure communication with the idea of the channel's value attitudes, its style and thematic preferences. If the context of the analogue source orients the user to certain conventions of dialogue and adherence to the norms of interpersonal communication, then the context of network communication is characterized by an attitude towards attracting a loyal audience and the mass nature of communication. At the intersection of these contexts, the mechanisms of the discursive effects of convergent radio are manifested in the organization of communication within stereotypical models of communicative behavior - in the actualization of users' typical reactions necessary for discourse for its self-reproduction. The manifestation of these reactions is considered based on the method of qualitative discourse analysis in the version proposed by Z. Yeager. The analysis of the material shows that discursive influence is manifested in the compulsion to mass character realized through the mechanisms of phatic control of communication embedded in the initiating text. Discourse creates strategic communication gaps in which users implement entertaining and socializing intentions. The choice for the analysis of texts of different genres demonstrated the commonality of the mechanism of influence: the phatic plan of texts of different genres implements the mode of infotainment - the entertaining and recreational activity of communicants who construct a spontaneous image of the world and emotionally experience it.
Reception of Religious Themes in Nikolai Leskov's Works at the Turn of the 20th Century
Authors:   University of Warsaw, Lukaszewicz Marta
Published: December 2021

The article aims to consider tendencies predominating in literary criticism at the turn of the 20th century in its reception of religious issues in Nikolai Leskov's works, to identify the peculiarities of their understanding by representatives of diverse groups and trends, to examine their influence on changes in Leskov's literary reputation. The role of the spiritual atmosphere of the Silver Age in changing attitudes towards Leskov's legacy is mentioned, as well as the consequences of the duality of his reception formed at that time. The research materials consists of various works of literary criticism (articles, notes, reviews) written and published in Russia between 1895 and 1917. They are studied using the methods of the thematic, discourse and comparative analysis of the text. The research demonstrated that the comprehension of Leskov's legacy, which began at the end of the writer's life, took place in the critical period of the coexistence of realism and symbolism in literature, and sociological and modernist trends in criticism. Leskov's literary works attracted mainly critics of the sociological trend, who emphasized the writer's evolution from a photographic depiction of Russian Orthodox clergymen's everyday life to the finding of peace, rational and moral understanding of religiosity akin to Protestantism and Leo Tolstoy's teaching. The approach of the less numerous modernist critics was different as they appreciated Leskov's depiction of the mystical depths of Orthodoxy, his penetration into the secrets of the popular faith and ability to juxtapose them with the mundane life. They evaluated the late works of the writer as less interesting, excessively rationalistic and moralising. Thus, the analysis of literary reviews of the turn of the 20th century allows making a conclusion about a strong influence of the artistic principles of the two main literary movements of the epoch, and critics' desire to incorporate Leskov into the modern context, thereby updating his legacy. Such a possibility is, in particular, the result of Leskov's ideological evolution and of the peculiarity of his manner of writing, with its elusive author's position, which still makes it feasible to formulate contradictory assessments of his works and personal religiosity, varying between a ‘heretic' and ‘profoundly Orthodox'. In addition, the author observed the fundamental importance of the category of literary reputation and noted the fact of transition from assessing the personality and socio-political stance of the author to evaluating his artistic output. It was also due to the beginning of the ‘linguistic turn' of the literary critics of the time, which resulted in the reception of Leskov's works becoming more complex and multifaceted. The contradictory assessment of his works and, in particular, their religious component, still continue to shape the position of many contemporary researchers.
Essays by Viktor Ya. Iretsky in the Context of the Journalism of 1917 and 1918
Authors:   Pskov State University (Pskov, Russian Federation), Semyonova Maria G.
Published: December 2021

This article aims to initiate a study of an extremely interesting body of texts by Viktor Ya. Iretsky that were published in the major metropolitan newspaper Rech' [Speech] and caused a resonance in 1917-1918. The study of the originality of the half-forgotten prose writer's revolutionary journalism in the context of the ideological searches of the author's famous contemporaries - M. Gorky, V.G. Korolenko, L.N. Andreev, A.A. Blok, I.A. Bunin - seems relevant. Based on newspaper, magazine, and book collections of the National Library of Russia, the Library of the Russian Academy of Sciences, and the House of Russia Abroad, the article analyzes the essays published in Rech' from March 1917 to August 1918 using historical-literary and intertextual research methods. In the course of the research, the author selected the most revealing essays that are comparable to well-known journalistic works about the revolution, analyzed their artistic originality, evolution, and similarity to the journalism of 1917-1918. Iretsky's texts are thematically and ideologically similar to Andreev's articles and diary entries, Korolenko's writings, and - particularly - Gorky's cycle published in Novaya Zhizn' [New Life]; however, theses texts describe the facts, moods, and the revolutionary atmosphere from the point of view of an observer who opposes the revolution and, since May 1917, sees it only as destructive force. The author concludes that Iretsky's essays, reflecting the metamorphoses of the intelligentsia's perception of the revolution, problems close to Gorky's and Korolenko's notes, are more similar to emigrants' diaries, especially Bunin's Cursed Days, in their confessional nature, antiBolshevik pathos and artistry. The specificity of Iretsky's texts is explained by the attention to specific everyday material immersed in the cultural and historical context. The value of the essays is determined by its orientation to everyday life, inclusion of the living tissue of life in the texts; by its confessional nature, which back in 1917 and 1918 revealed a critical emigrant attitude - then expressed in diaries only - to the course of the revolutionary transformation of Russia; and by the inclusion of expressive historical and cultural figurative elements. Abstracting, analyzing the situation from the point of view of European history and culture (including the ideals of the French revolution), using images of works of Russian literature (Dead Souls by Gogol, The Cherry Orchard by Chekhov, The Brothers Karamazov by Dostoevsky, etc.) and reminiscences on them, Iretsky does not approach authors of political pamphlets, but rather such important figures of Russian journalism as Maxim Gorky and Vladimir Korolenko, and the diary prose of the brightest Russian writers.
The Theme of Love in Russian Philosophical Utopias of the 1920s and 1930s (Andrei Platonov and Stepan Kalachov)
Authors:   Far Eastern State Institute of Arts, Mitina Natalya G.
Published: December 2021

The article discusses the role of feelings in shaping the society of the future using two concepts created in the 1920s and 1930s in Russia. These are the projects of Andrei Platonov and Stepan Kalachov, which can be attributed to the philosophy of love. The concepts reflect the features of the post-revolutionary era and are linked to the transformation of the period. Despite some similarities between the projects, each has its own characteristics. Platonov's conception is characterized by a transformation we witness at the end of the 1930s, which was connected with the change of the philosopher's attitude to the development of society and the relationship between the sexes, and was due to the construction of communism in the country and the methods used for this purpose. There is no such change in the utopia of Kalachov's eroica, and the basic precepts laid down in the 1920s continue to evolve further into the concept of life wisdom. The first period in Platonov's work is connected with the ideas of technocracy and asceticism in the relationship between the sexes. In this regard, the sensual aspect is suppressed and destroyed as an impediment to the grand transformation of society; hence the new techniques of destroying sexual instinct, preaching chastity. In the society to be created, the mind suppresses feelings, which determines the attitude to the woman and the feminine that become of secondary importance. Gradually, the philosopher becomes disillusioned with the ongoing transformations of the Bolsheviks, and his attitude towards women and feelings changes. Kalachov's eroica conception refers to erotic utopia and represents the synthesis of eroticism and heroics of the era. Kalachov reveals the sensual and bodily aspect of the society of the future. He has the ideas of technocracy, which relates him to Platonov's conception. However, Kalachov does not abandon feelings in the new society, and the theme of love is central to him. Some features of the conception echo the views of some members of the Marxist ideology (Alexandra Kollontai), but generally do not reflect the views of the official authorities. Both projects reflect the characteristics of the era that created them, offer a solution to the problem of gender relations, and reveal the importance of love in society. Love in these projects is a transformative beginning that can change the human being and society, and lead the world to universal harmony. However, in the context of the communist project, in which the spirit of freedom of the first post-revolutionary years was destroyed, they could not be realized and remained utopias.
The Potential of the Main Political Parties in Contemporary Russia
Authors:   Chelyabinsk state university (Chelyabinsk, Russia), Ivanov Vitaly N.
Published: December 2021

The object of the research is the modern party system in Russia. The aim of the article is to study the organizational, financial, and political potential of the main parliamentary political parties: Edinaya Rossiya (United Russia (UR)), CPRF, LDPR, and Spravedlivaya Rossiya (A Just Russia). The comparative analysis of party resources revealed a significant disparity between the potential of UR and the opposition parties. The latter are inferior to the UR in terms of the number of members and the development of the organizational structure. The total number of members and local organizations of these parties is one-third of UR's indicators. The lack of a developed infrastructure for the opposition parties preserves their limited representation and influence at the local level of public power. The financial potential of the parties is formed mainly by state funding and donations from sponsors. Today, four parliamentary parties are eligible for state support. The share of public finance in their budgets is more than half of all revenues. They also receive the bulk of donations, the size of which is limited by law and is official in nature. It can be argued that Russia has formed a mechanism that allows the state to support parties without allowing the establishment of monopoly influence on their activities by individuals and elite groups. The political potential of the parties is determined by the level of their representation in state and local government bodies. Today it is dominated by UR. Its parliamentary fractions actually control the legislative branch of power at the federal and regional levels. Together with the presidential structures of power, UR also ensures the election of presidential creatures to the posts of heads of regions. Party members today form the basis of the governor's corps, with a single representation from other political parties. UR's organizations include more than half of deputies and heads of municipalities, ensuring its influence on the local government system. The high level of dominance of UR and the limited potential of the opposition parties is an important condition for the stability of the existing political regime. UR's significant opportunities allow the ruling elite to maintain and strengthen their positions: cut off the forces of the radical opposition from power, control the legislative process providing legal support for decisions of the government and the head of state, consolidate the federal and regional elite, ensuring the rotation of elites and coordination of their interests. In these circumstances, the parties of the parliamentary opposition are important for preserving the democratic nature of the political process. They do not question the dominant role of UR, offer limited competition to it, and do not have the potential to really influence key political decisions.
Factors Affecting Automatic Positive Airway Pressure Therapy Adherence in Patients Who had Completed the 3-Month Compliance Assessment for Korean National Health Insurance Coverage
Authors: Kim Min Su , Kim Min Gyu , Kang Jae-yoon , Chung Jae in , Seo Yu Ju , Park Soo-Kyoung , Rha Ki-Sang , Kim Yong Min
Published: December 2021

Background and Objective The numbers of prescriptions for continuous positive airway pressure and automatic positive airway pressure (APAP) machines have increased dramatically since the Korean government changed national health insurance coverage. This study examined adherence to APAP therapy in patients with obstructive sleep apnea who completed the 3-month adaptation period required by the insurance service, and evaluated the factors predictive of good adherence.Methods We retrospectively reviewed the medical records of a total of 315 patients who received APAP prescriptions between July 2018 and December 2019. After screening, 189 patients were analyzed. Patients were divided into an adherent (AD) group and a non-adherent (NAD) group based on 9 months’ APAP adherence. Patient demographics, medical history, body mass index and pretreatment polysomnography results, as well as APAP therapy adherence-related variables, the 90th percentile pressure, residual apnea hypopnea status, and type of devices or managers were compared between the two groups.Results We found mean usage times, mean pressures, days with ≥ 4 hours of use a day, and 90th percentile pressures differed significantly between the AD and NAD groups. The device-related data at months 1 and 3 and 9 were similar. One type of device performed differently compared to the other devices, but this did not affect adherence.Conclusions The mean pressure and 90th percentile pressure were the main determinants of adherence in patients who passed a 3-month compliance assessment conducted by the Korean National Institute of Health. The data on adherence at months 1, 3 and 9 were similar.
Utility of the Stress and Anxiety to Viral Epidemic-3 Items as a Tool for Assessing Work-Related Stress, and Relationship With Insomnia and Burnout of Healthcare Workers During the COVID-19 Pandemic
Authors: Son Hoon Sung , Ahn Myung Hee , Kim Kyumin , Cho Inn-Kyu , Lee Joohee , Suh Sooyeon , Chung Seockhoon
Published: December 2021

Background and Objective The aim of this study is to explore the usefulness of the Stress and Anxiety to Viral Epidemic-3 items (SAVE-3) scale as a tool for assessing work-related stress in healthcare workers.Methods There were 389 participants and all remained anonymous. The SAVE-9, the Patient Health Questionnaire-4, the Maslach Burnout Inventory-Human Services Survey for Medical Personnel (MBI-HSS-MP), the perceived stress scale (PSS), and single item insomnia measure were used. After checking whether the SAVE-3 scale is clustered into a sole factor from SAVE-9 scale based on principal component analysis with promax rotation, confirmatory factor analysis (CFA) was done on the 3 items of the SAVE-3 to examine the factorial validity for a unidimensional structure.Results The SAVE-3 was clustered with factor loadings from 0.664–0.752, and a CFA revealed that 3 items of the SAVE-3 cohered together into a unidimensional construct with fit for all of indices (comparative fit index = 1.00; Tucker Lewis index = 1.031; standardized root-mean-square residual = 0.001; root-mean-square-error of approximation = 0.00). The SAVE-3 scale showed acceptable reliability (Cronbach’s α = 0.56 and McDonald’s ω = 0.57) in this sample. A high SAVE-3 score correlated significantly with younger age (r = -0.12, p = 0.02), a high PSS score (r = 0.24, p < 0.001), a high total score for the MBI-HSS-MP (r = 0.35, p < 0.001) and all of its subscales (emotional exhaustion, r = 0.40, p < 0.001; personal accomplishment, r = -0.14, p < 0.005; depersonalization, r = 0.39, p < 0.001), and poor sleep quality (r = 0.15, p < 0.001).Conclusions Taken together, the data suggest that SAVE-3 is a reliable, valid, and usable scale for measuring work-related stress in healthcare workers during the COVID-19 epidemic.
MA's trial protocol 2 v1
Authors: Ann Moran Mary
Published: December 2021

trial protocol 2
A Supplemental Guide to Building the optoPlate-96 v1
Authors: J Dunlop Mary
Published: December 2021

The optoPlate-96 is a device that uses small LEDs to illuminate cell cultures in a 96-well plate. It was developed by Lukasz Bugaj and Wendell Lim. If you haven’t read the original optoPlate-96 paper and its Supplementary Information you should start there (Bugaj and Lim, Nature Protocols 2019). During the COVID-19 shutdown I made an optoPlate-96 in my basement over the course of many months. The protocol is detailed and awesome. But there are some things it doesn’t tell you, a few small typos, and several places where I just got confused. If you’ve never ordered a PCB or done reflow soldering, but are interested in giving it a try, this guide is for you.
[RETRACTED] Whoopi Goldberg CBD Gummies – Get Natural Healing With This Hemp Gummies v1
Authors: CBD Gummies whoopigoldberg
Published: December 2021

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Modified NEBNext® VarSkip Short SARS-CoV-2 Library Prep Kit for Illumina Platforms - adapted for wastewater samples v1
Authors: Ramachandran Padmini , Walsky Tamara , Windsor Amanda , Hoffmann Maria , Grim Chris
Published: December 2021

PURPOSE: This method was developed at the FDA’s Center for Food Safety and Applied Nutrition for GenomeTrakr’s pandemic response project, monitoring SARS-CoV-2 variants in wastewater. Protocols developed for this project cover wastewater collection, concentration, RNA extraction, RT-qPCR, library prep, genome sequencing, quality control checks, and data submission to NCBI. This modified protocol details methods for cDNA synthesis and library preparation for sequencing of wastewater samples containing SARS-CoV-2. The protocol is based primarily on the NEBNext® ARTIC SARS-CoV-2 Library Prep Kit (Illumina®), NEB #E7650S/L 24/96 reactions, with a few modifications. Primarily, VarSkip Short primers are used in place of the ARTIC V3 primers. These primers are available in the NEBNext®ARTIC SARS-CoV-2 FS Library Prep Kit (Illumina®); however, for optimal variant detection from wastewater, sequenced fragments should be as large as possible, so we discourage fragmentation prior to end prep. There are a couple of decision points in this protocol. Examining cDNA amplicon samples on an Agilent TapeStation system or similar fragment analyzer is extremely helpful in making these decisions.
Isolation of nuclei from frozen human skeletal and cardiac muscle for single nucleus RNA and chromatin assays v2
Authors: R Hocker James , Preissl Sebastian , H Diep Dinh
Published: December 2021

This protocol was adapted for the isolation of single nuclei from frozen skeletal and cardiac muscle tissues for molecular characterization with the SNARE-seq2, sci-ATAC-seq, and snRNA-seq assays. References: (1) Preissl et al (2015). Circulation Research. Doi: 10.1161/CIRCRESAHA.115.306337 (2) Hocker et al (2021). Science Advances. Doi: 10.1126/sciadv.abf1444
[RETRACTED] Alpha IQ Brain - A Safe Drug to Boost Brainpower (REAL-PEOPLE-REVIEWS) v1
Authors: IQ Brain Alpha
Published: December 2021

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[RETRACTED] Scam Alert! Elite Power CBD Gummies + Oil Reviews | UK, CA (Canada), USA v1
Authors: not provided johni
Published: December 2021

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Guardian Blood Balance Australia (ALERT FRAUD) Does This Botanicals Blood Balance Formula Really Works? Read Shocking Report! v1
Authors: not provided bloodbalance
Published: December 2021

Guardian Botanicals Blood Balanceis a groundbreaking blood support product that uses a combination of natural ingredients to increase blood levels.Guardian Blood Balance Supplement also maintains the proper bloodstream, blood sugar, pressing factors, cholesterol levels.Healthy blood circulation promotes weight loss by increasing metabolism and making you slimmer.A different version of scientific research is available to address the root cause of the problem and restore normal levels with natural elements.
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Authors: not provided health
Published: December 2021

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Effects of axial loaded magnetic resonance imaging of lumbar spine on dural sac and lateral recesses
Authors: Bulja Deniz , Strika Jasna , Jusufbegović Merim , Bečirčić Muris , Šehić Adnan , Julardžija Fuad , Beganović Adnan , Zukić Fuad , Vegar-Zubović Sandra
Published: December 2021

Introduction: Axial-loaded magnetic resonance imaging (MRI), which can simulate an upright position of the patient may cause a significant reduction of the dural sac cross-sectional area (DCSA) compared with standard MRI, thus providing valuable information in the assessment of the lumbar spinal canal. The purpose of this study was to investigate excessiveness of the change in DCSA and depth of lateral recesses (DLRs) before and after axial-loaded imaging in relation to body mass index (BMI) of the subjects.Methods: Twenty patients were scanned to evaluate DCSA and DLR at three consecutive lumbar spine intervertebral disc levels (L3/4, L4/5, and L5/S1) on conventional-recumbent MRI, and after axial loading were applied.Results: Axial-loaded MRI demonstrates a significant difference of DSCA in comparison to conventional MRI. Furthermore, results show a significant correlation between the DCSA and BMI on level L3/L4, both before and after axial loading MRI. With axial loading, there is a reduction of DSCA of 12.2%, 12.1%, and 2.1% at the levels L3/L4, L4/L5, and L5/S1, respectively. After axial loading has been applied, the depth of the neural foramen has been reduced by an average of 10.1%.Conclusion: Axial-loaded MRI reduces DCSA and DLRs in comparison to standard MRI. Information obtained in this way may be useful to explain the patient’s symptomatology and may provide an additional insight that can influence the treatment decision plan accordingly.
Correction of age-related skin changes on face by the method of exposure to high-frequency currents of the radio wave range and autologous platelet-rich plasma: randomized study
Authors: Teplyuk Natalia P. , Lebedeva Serafima V.
Published: December 2021

BACKGROUND: In the literature, there are no scientifically based studies on the use of combination therapy using radio wave lifting and autologous platelet-rich plasma for the correction of involutional changes in the skin of the lower third of the face.
AIMS: To determine the effect of complex therapy of involutional changes in the skin of the lower third of the face with minimally invasive radio wave lifting using a cannula electrode and platelet-rich autoplasma using non-invasive diagnostic methods.
MATERIALS AND METHODS: Examination and treatment of 55 healthy women of Slavic appearance with involutional changes in the skin of the lower third of the face were carried out. Group № 1 patients received radio wave lifting therapy (n=28) and group № 2 patients received combined therapy with radio wave lifting and autologous platelet-rich plasma (n=27). The study was conducted from January 2020 to December 2020. To assess the condition of the skin, laser Doppler flowmetry, ultrasound sonography, and elastometry were used before and after the study. Clinical manifestations were assessed by an anthropometric method.
RESULTS: The most pronounced changes were observed in the group where the combined method of radio wave lifting therapy with autologous platelet-rich plasma was used. The change in microcirculation was of a multidirectional nature, however, the average values were in the range of 8.8668.89 pf units, which is the normalization of trophic processes in tissues (p 0.05). When analyzing the conduct of ultrasound sonography, statistically significant thickening of the epidermis and dermis was noted, however, in patients of the second group, the thickening was more pronounced (p 0.0005). The change in the echogenicity of the dermis was of a multidirectional nature; by the end of treatment, the mean values were in the range of 10.511.3 units, which, apparently, indicates a more homogeneous structure of the dermis (p 0.05). Anthropometric indices (measurement of ptosis of the lower cheeks) decreased in both groups, which is related to skin lifting as a result of treatment (p 0.0005). The amplitude of tissue upward mobility decreased in both groups (p 0.0005). The amplitude of downward movement of tissues after therapy was of a multidirectional nature in both groups, which is possibly associated with the density of the dermis and indicates the normalization of collagen and elastin fibers (p 0.05). Elastometry indices (F0, R4, R6, R8) decreased, R2 increased in both groups, however, the dynamics was more pronounced in the second group (p 0.0005).
CONCLUSIONS: Minimally invasive radio wave lifting in combination using a channel electrode with autologous platelet-rich plasma is an effective and safe method of treating age-related changes in the skin of the lower third of the face.
Combined treatment regimen for severe acne vulgaris
Authors: Kruglova Larisa S. , Gryazeva Natalia V. , Tamrazova Anait V.
Published: December 2021

BACKGROUND: Treatment of acne vulgaris remains an actual task of practical medicine. Despite the fact that the participation of severe acne in the structure of the morbidity of acne vulgaris is relatively small, precisely they most often leave behind scars, are accompanied by a pronounced cosmetic defect and significantly reduce the patients quality of life. Systemic treatment with isotretinoin is the gold standard of management of such patients, but this type of treatment is often accompanied by an exacerbation reaction, which negatively affects the general condition of the patient and reduces the compliance of treatment.
AIM: To determine the effectiveness of the combined use of isotretinoin and a systemic corticosteroid in the treatment of severe forms of acne.
MATERIALS AND METHODS: We observed 27 patients (16 men and 11 women) with severe or very severe grade on the IGA scale. All patients received combination therapy with isotretinoin (Sotret) at a dose of 0.5 mg/kg/day (cumulative dose from 120 to 150 mg/kg) for 8 months and prednisolone 30 mg/day 7 days, followed by dose reduction within a month. The assessment of treatment efficacy was based on the IGA scale, indicators DIA, DLQI and counting the number of inflammatory and non-inflammatory elements.
RESULTS: During the 8 months of the study, 81.4% of patients achieved a 2-point reduction in the degree on the IGA scale (clear or almost clear skin). The DLQI index showed 74.9% improvement compared to the start of treatment. The average DIA values decreased by 72%. The reduction in the number of inflammatory and non-inflammatory elements showed a marked clinical improvement (91.4% for nodules and 98.3% for pustules). Exacerbations of acne were recorded in 18.5% of patients.
CONCLUSIONS: Combined systemic treatment with isotretinoin and prednisolone for severe acne decreases the number of exacerbations and reduces the duration of treatment.
Lichen sclerosus as a variant of limited scleroderma with damage to the anogenital region
Authors: Bagramova Gayane E. , Snarskaya Elena S. , Shnakhova Lydia M. , Semenchak Yulia A.
Published: December 2021

Lichen sclerosus is one of the clinical variants of limited scleroderma, a feature of which is the defeat of the anogenital zone. The issues of the etiology and pathogenesis of lichen sclerosus remain not fully understood, despite numerous studies in which the polygenic nature of inheritance and multifactoriality in the implementation of dermatosis are noted.
With the progression of the scleroatrophic process and the absence of timely pathogenetic therapy, there is a high probability of the development of comorbid pathology with a whole range of symptoms, such as urinary (dysuria, recurrent urinary tract infections - cystitis, urethritis, cystourethritis), gastrointestinal (pain during defecation, chronic constipation), vaginal severe dryness and increased sensitivity of the vaginal mucosa, burning, itching).
Treatment of patients with lichen sclerosus with lesions of the anogenital zone causes great difficulties. In cases of isolated localization of scleroatrophic lesions of anogenital localization, difficulties may arise in the differential diagnosis with diseases of similar localization, such as vitiligo, atrophic lichen planus, basal cell carcinoma, contact dermatitis, nonspecific balanoposthitis, Keir's erythroplasia. Treatment of limited scleroderma, the clinical variant of which is lichen sclerosus, should be multi-course and complex, with the obligatory use of penicillin antibiotics, hyaluronidase-based drugs, drugs that improve microcirculation, vitamins, immunoregulators and physiotherapeutic methods.
Thus, early diagnosis and timely pathogenetic therapy contribute to the prevention of the risks of developing genitourinary syndrome, progression of tissue sclerosis, and psychoemotional disorders.
This article presents a clinical case of diagnosis and treatment of a patient with lichen sclerosus.
Psychosomatic aspects of psoriasis (review)
Authors: Dorozhenok Igor Yu. , Ilina Ekaterina V.
Published: December 2021

The review reflects the increased scientific interest in the psychosomatic aspects of psoriasis in the world literature in recent years. The studied material of the articles is structured according to the principles of the modern clinical psychosomatic approach. The introduction substantiates the relevance of studying this topic. The article considers the stress manifestations/examinations of psoriasis under the influence of psychosocial acute and chronic stress, including under the action of the COVID-19 pandemic; the quality of life and stigmatization of patients with psoriasis. The driving factors leading to the formation of nosogenic psychosomatic disorders are identified: common disfiguring rashes, itching, recurrent course, the threat of disability, social restrictions, constitutional premorbid features of patients. The description of comorbid mental disorders of the anxiety and affective range with a discussion of suicidal risk is presented. A separate section of the review is devoted to itching, as one of the most discussed aspects of psoriasis in the modern literature. Different points of view on the psycho-biological structure of itching in psoriasis are presented. Various factors related to the intensity, objective and subjective perception of itching are considered. Among them are the clinical form and severity of psoriasis, the localization and prevalence of rashes, gender, age, level of education, marital status of patients, concomitant somatic and mental diseases.
A new principle for the diagnosis morphea in the onset of the disease
Authors: Zaslavsky Denis V. , Sidikov Akmal A. , Garyutkina Lyubov V. , Pyagai Grigoriy B. , Alaeva Muyassar D. , Ibragimova Nargiza S. , Malikova Nilufar N. , Kozlova Darya V.
Published: December 2021

BACKGROUND: Because of the low specificity morphea clinical manifestations in early stages, the differential diagnosis is difficult.
AIMS: The purpose of the research is to propose a new diagnostic method for early stages of localized scleroderma.
MATERIALS AND METHODS: During 20112020, 77 patients with clinical manifestations of morphea and 127 controls were examined and included in the study at the LenOblCenter. All participants were conducted a transcutaneous oximetry with the TCM-400 Radiometer apparatus. The tissue oxygen perfusion (tcpO2) level from 40 to 50 mm Hg was considered as a reversible decrease, from 30 to 40 mm hg was a borderline decline and the value below 30 mm hg was critical. The following diagnostic skin biopsy was conducted in all 77 patients
RESULTS: Skin biopsy allowed to form 4 research groups: 40 patients with morphea, 12 patients with granuloma annulare, 15 patients with small plaque parapsoriasis and 10 individuals with large plaque parapsoriasis. 7 (17.5%) patients with morphea had normal tcpO2 values, 9 (22.5%) patients had significant decrease of tcpO2, 24 patients (60%) showed a reversible decrease of tcpO2. 3/12 (25%) patients with granuloma annulare and 1 patient (10%) with large plaque parapsoriasis had minor oxygen level decrease. Measurement on the healthy skin showed tcpO2 decrease in patients with comorbidities ― 3/77 (3.9%) in research group and 28/127 (22%) in controls.
CONCLUSIONS: Transcutaneous oximetry is a new perspective direction in the diagnostic algorithm of the morphea based on the pathogenesis and morphological features of the disease.
Cholinergic urticaria: novel aspects of pathogenesis, diagnosis and management
Authors: Borzova Elena Yu. , Popova Christina Yu. , Kurowski Marcin , Rukhadze Maia T. , Darlenski Razvigor , Zaborova Viktoriya A. , Kurshev Vladislav V.
Published: December 2021

Cholinergic urticaria (CholU) is a chronic inducible urticaria, characterised by itchy pinpoint wheals up to 3 mm in diameter, surrounded by a prominent flare, that occur following an exposure to characteristic triggers such as active or passive heating, physical exercise, emotions, hot or spicy foods. Key pathophysiologic mechanisms include immediate hypersensitivity to autologous sweat antigens, functional sweating disorders, impaired acethylcholine metabolism, abnormal skin vascular permeability and disturbed skin innervation. Clinical manifestations of CholU may vary from typical itchy pinpoint urticarial lesions, angioedema to anaphylaxis. Atypical CholU forms include cholinergic pruritus, cholinergic dermographism, cold cholinergic urticaria and persistent cholinergic erythema. The diagnosis of cholinergic urticaria relies on patients history, сlinical manifestations and challenge tests. Treatment options include nonsedating H1 antihistamines in standard or increased doses. The evidence is accumulating for the use of biological treatment with omalizumab in cholinergic urticaria. The prospect of personalized treatment of cholinergic urticaria include autologous sweat desensitization. The main research efforts in ColdU are directed at optimizing diagnostic approaches and developing innovative therapeutic options.
Dominio afectivo e inteligencias múltiples de maestros en formación de la Universidad de Extremadura
Authors: Hernández del Barco Miriam Andrea , Corbacho-Cuello Isaac
Published: December 2021

En este estudio se realiza un análisis descriptivo e inferencial de las emociones experimentadas por una muestra de maestros en formación hacia la enseñanza de las ciencias, la identificación de su estilo de aprendizaje según la teoría de las inteligencias múltiples de Gardner (2011), el estudio de la percepción de autoeficacia hacia los distintos contenidos científicos y el establecimiento de correlaciones entre las variables. Los resultados obtenidos muestran que los maestros en formación sienten mayor rechazo hacia la física y química que hacia la biología y geología y que es posible establecer diferencias en las emociones hacia las ciencias según sus estudios de procedencia. Con respecto a la autoeficacia, se encuentran correlaciones entre sentir emociones positivas hacia la ciencia y tener una mayor autoeficacia frente a la enseñanza de los contenidos. También entre poseer determinados estilos de inteligencia, emociones y autoeficacia.
Unidad didáctica sobre los cambios químicos que intervienen en el efecto invernadero
Authors: Martínez Carmona Marina , López Banet Luisa
Published: December 2021

En este trabajo se proponen actividades secuenciadas como parte de una unidad didáctica sobre la enseñanza de los cambios químicos que intervienen en el efecto invernadero para abordar el aprendizaje de la Química con sentido y desarrollar, no solo la comprensión de los contenidos científicos, sino también cómo se construyen. En concreto, se ha diseñado con la intención de promover objetivos competenciales relacionados con los fundamentos de la disciplina que permitan dar respuesta a las cuestiones estructurantes surgidas del contexto implicado. La unidad didáctica integra actividades centradas en el alumnado, como investigaciones en las que se recogen e interpretan datos para el establecimiento de conclusiones, tareas de argumentación o el aprendizaje basado en juegos. Una prueba inicial con alumnado de 2º de ESO ha permitido establecer su idoneidad para este nivel educativo, resultando un recurso relevante y motivador para la introducción de los contenidos seleccionados.
La evocación de la nostalgia en las ficciones audiovisuales: el caso de Ready Player One
Authors: Cenizo Coral
Published: December 2021

La nostalgia es un rasgo inherente en la sociedad posmoderna cuyo arraigo se ha afianzado con el desarrollo del llamado retromarketing. El objetivo de la investigación es analizar qué elementos se utilizan en la película Ready Player One para transmitir nostalgia al espectador y de qué forma estos son utilizados para generar este sentimiento. Para ello, se lleva a cabo un análisis de contenido de cuatro componentes de la mencionada ficción audiovisual: situaciones dramáticas, personajes, escenarios y objetos. Los resultados demuestran que estos cuatro elementos se utilizan de forma constante para trasmitir nostalgia. Su asociación con hechos u objetos del pasado crea a lo largo de toda la cinta una permanente nostalgia que permite al espectador construir un vínculo emocional más fuerte con la historia y con los personajes por el recuerdo evocador que le provocan. Así, la nostalgia puede imbricarse en diferentes y muy diversos aspectos de un producto de marketing para generar una mayor conexión con los consumidores.
Factores que influyen en la orientación a la venta ética en las pequeñas y medianas empresas (PYMES)
Authors: Martín-Castejón Pedro Juan , Gómez-Martínez Alberto
Published: December 2021

Es indudable la trascendencia que en el ámbito empresarial se otorga a la fuerza de ventas como la gran dinamizadora para alcanzar los objetivos corporativos. En la actualidad, resulta fundamental mencionar la venta ética y la Responsabilidad Social Corporativa (RSC) como estrategia empresarial encaminada a la consecución de dichos objetivos. Por este motivo, el objetivo del presente trabajo es realizar un estudio sobre los factores que influyen en la empresa hacia la orientación a la venta ética, particularizada en un contexto de PYMES. Basado en un estudio empírico a 94 empresas en el ámbito de la Región de Murcia (España). Los resultados del estudio ponen de manifiesto la relación directa entre el nivel de formación del CEO y la orientación hacia la venta ética. Asimismo, cuando al nivel de formación universitario del CEO le acompaña la implantación de una Memoria de RSC en la organización, favorece que aumente la orientación empresarial hacia la venta ética.
Storytelling and retromarketing: strengthening brand communication
Authors: Sousa Vânia
Published: December 2021

Brands are becoming more aware of the importance of adding value to their products through storytelling. The aim of this article is to raise awareness of the power of storytelling and retromarketing to enhance the effectiveness of brand communication strategies and increase customer loyalty. The study consisted of an analysis of the chemicals produced in the brain during the telling of different types of stories and their influence on consumer behaviours, and of brand archetypes, based on the work of Carl Jung in this area. The study also conducted a review of experiments that demonstrate the economic value of storytelling and retromarketing narratives. The results show that storytelling and retromarketing enhance brand uniqueness and create a deeper, more genuine relationship between companies and customers. This emotional connection may be achieved when storytelling is targeted at a specific audience as part of a larger marketing strategy.
EFEITOS DE DIFERENTES FONTES DE MATERIAL ORGÂNICO NA FERTILIDADE E UMIDADE DO SOLO
Authors: Fernanda Alves Daniela , Silva Franco Junior Kleso , Giselle Prado Brigante Giselle , De Souza Dias Márcio , Scalco Ferreira Natália
Published: December 2021

Soil is a resource of fundamental importance for agriculture, one of its functions being the balanced supply of nutrients to plants. One of the ways to make the soil sustainable is by applying organic matter, which can be of animal or vegetable origin. The objective was to evaluate the effect of adding different organic materials to the soil in relation to its fertility and moisture. Conducted an initial analysis to analyze soil fertility. Then the area was divided into plots and the treatments were applied, which consisted of 40 ton ha-1 cattle manure, 5 ton ha-1 poultry manure, 53 ton ha-1 swine manure, 30 ton ha-1 coffee straw and 0 ton ha-1 organic material (control). After 90 days, samples were taken from this soil to analyze its fertility and moisture. The treatments that best contributed to its fertility were swine and cattle manure and the treatment that retained more moisture was coffee straw.
Dış Borçlanma, İktisadi Büyüme, Cari Açık ve Finansal Gelişme İlişkisi: Türkiye Örneği
Authors: ÇEŞTEPE Hamza , TAY BAYRAMOĞLU Arzu , SÜMER Enes
Published: December 2021

Bu çalışmada, Türkiye ekonomisinde dış borçlar ile ekonomik büyüme, cari açık ve finansal gelişme arasındaki ilişki ARDL eşbütünleşme yöntemi ile incelenmektedir. Çalışma 1998:Q1-2019:Q2 dönemini kapsamaktadır. Çalışmada elde edilen ekonometrik bulgulara göre, dış borçlanma ile ekonomik büyüme, cari açık ve finansal gelişme arasında eşbütünleşme ilişkisi mevcuttur. Buna göre, uzun dönemde ekonomik büyüme ve finansal gelişme ile dış borçlanma arasında pozitif ilişki, cari açık ile dış borçlanma arasında negatif ilişki tespit edilmiştir. Bu sonuçlar, Türkiye ekonomisinde tasarrufların yatırımları finanse etmeye yetmediğini, ithalata bağımlı üretim yapısının mevcut olduğunu ve ekonominin borçla büyüyebildiğini göstermektedir.