bluuebunny/crossref_metadata_2025 huggingface dataset:
Case report: Neuroacanthocytosis associated with novel variants in the VPS13A gene with concomitant nucleotide expansion for CANVAS and assessment with osmotic gradient ektacytometry
Authors: Paucar Martin , Wincent Josephine , Rubin Charlotta , Peikert Kevin , Kyhle Josefin , Hertegård Stellan , Möller Riita , Beshara Soheir , Svenningsson Per
Published: October 2024

Background and objectives

The diseases historically known as neuroacanthocytosis (NA) conditions include VPS13A disease (formerly chorea-acanthocytosis) and XK disease (formerly McLeod syndrome). Here we report a patient with a hyperkinetic syndrome associated with variants in VPS13A with a concomitant homozygous nucleotide expansion in Replication factor C, subunit 1 (RFC1) and evaluate the role of ektacytometry for the assessment of acanthocytes.

Methods

Investigations included clinical assessments, neuroimaging studies, laboratory analyses, blood smears, ektacytometry, psychometric evaluation, and genetic analyses. Using ektacytometry, an osmoscan curve is obtained yielding a diffraction pattern as a measure of average erythrocyte deformability from circular at rest to elliptical at a high shear stress. The pattern allows the derivation of several parameters (mainly EI-max, O-min and O-Hyper points). Samples from two other patients with genetically proven VPS13A disorder and XK disease and varying numbers of acanthocytes as well as from a fourth with acanthocytosis due to liver failure were also analyzed.

Case presentation

The patient has impulsivity, chorea and disabling feeding dystonia refractory to treatment and 15% acanthocytes in peripheral blood. Genetic workup revealed compound heterozygous variants c.1732_1733del; p.(V578Ffs*9) and c.8282C > A, p.(S2761*) in VPS13A with absence of chorein in the blood, the latter variant is novel. In addition, he harbors a homozygous nucleotide expansion in the RFC1 gene, reported in cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS). However, the patient does not display ataxia yet. Ektacytometry revealed significantly reduced erythrocyte deformability in this patient and in another man with VPS13A disease. In contrast, the patient with XK disease had 2% acanthocytes and mild abnormalities on ektacytometry. In the three cases, ektacytometry yielded a specific pattern, different from acanthocytosis due to liver failure.

Conclusion

Pathogenicity of the VPS13A variants is confirmed by absence of chorein, long-term follow up is required to evaluate any synergistic impact of for the underlying CANVAS mutation. New generation ektacytometry provides an objective measurement of erythrocytes’ rheological properties and may serve as a complement to blood smears. Finally, ektacytometry’s ability to detect deformability of erythrocytes in NA seems to depend on the degree of acanthocytosis.
Molecular determinants of resurgent sodium currents mediated by Navβ4 peptide and A-type FHFs
Authors: Xiao Yucheng , Pan Yanling , Xiao Jingyu , Cummins Theodore R.
Published: October 2024

Introduction

Resurgent current (INaR) generated by voltage-gated sodium channels (VGSCs) plays an essential role in maintaining high-frequency firing of many neurons and contributes to disease pathophysiology such as epilepsy and painful disorders. Targeting INaR may present a highly promising strategy in the treatment of these diseases. Navβ4 and A-type fibroblast growth factor homologous factors (FHFs) have been identified as two classes of important INaR mediators; however, their receptor sites in VGSCs remain unknown, which hinders the development of novel agents to effectively target INaR.

Methods

Navβ4 and FHF4A can mediate INaR generation through the amino acid segment located in their C-terminus and N-terminus, respectively. We mainly employed site-directed mutagenesis, chimera construction and whole-cell patch-clamp recording to explore the receptor sites of Navβ4 peptide and FHF4A in Nav1.7 and Nav1.8.

Results

We show that the receptor of Navβ4-peptide involves four residues, N395, N945, F1737 and Y1744, in Nav1.7 DI-S6, DII-S6, and DIV-S6. We show that A-type FHFs generating INaR depends on the segment located at the very beginning, not at the distal end, of the FHF4 N-terminus domain. We show that the receptor site of A-type FHFs also resides in VGSC inner pore region. We further show that an asparagine at DIIS6, N891 in Nav1.8, is a major determinant of INaR generated by A-type FHFs in VGSCs.

Discussion

Cryo-EM structures reveal that the side chains of the critical residues project into the VGSC channel pore. Our findings provide additional evidence that Navβ4 peptide and A-type FHFs function as open-channel pore blockers and highlight channel inner pore region as a hotspot for development of novel agents targeting INaR.
Significance of apparent diffusion coefficient in diagnosis of rectal carcinoma
Authors: Šarošković Milica , Vuković Miloš , Stojanoski Stefan , Zorić Milica , Prvulović Bunović Nataša , Spirovski Milena , Nosek Igor
Published: October 2024

Introduction

The apparent diffusion coefficient (ADC) is a quantitative parameter that facilitates the detection and reliable differentiation of rectal cancer. MR differentiation between rectal carcinoma, post-radiation proctitis, and normal rectal wall with the ADC values and their comparison depending on the level of tumor markers and pathohistological characteristics of rectal carcinoma.

Methods

The retrospective study performed at the Oncology Institute of Vojvodina included 300 patients, 100 each with rectal cancer, post-radiation proctitis, and normal rectum. Mean ADC values were obtained by measuring the region of interest (ROI) of the rectal wall.

Results

Rectal cancer showed lower ADC values (0.665 ± 0.086 x 10-3mm2/s) compared to both post-radiation proctitis (1.648 ± 0.268 x 10-3mm2/s) and normal rectum (1.180 ± 0.110 x 10-3mm2/s) (p<0.001). No significant differences in ADC values were observed between different grades of rectal cancer (p=0.874; p>0.05), depending on the presence of metastases in the lymph nodes (p=0.357; p>0.05), different TN stage (p=0.196; p>0.05), local spread of the tumor (p=0.312; p>0.05), the presence of RAS mutation (p=0.829; p>0.05) and the value of tumor markers (p=0.923; p>0.05). ADC values below 1.013 x 10-3mm2/s with 100% sensitivity and 96% specificity indicate the presence of rectal cancer in relation to normal wall, with a positive predictive value of 96.1% and a negative of 100%. ADC values below 1.255 x 10-3mm2/s with 100% sensitivity and 95% specificity indicate rectal cancer in relation to post-radiation proctitis. ADC values above 1.339 x 10-3mm2/s with 87% sensitivity and 89% specificity indicate post-radiation proctitis in relation to normal wall.

Discussion

The ADC is a useful marker in differentiating between rectal cancer, post-radiation proctitis, and normal rectal wall with high sensitivity and specificity, but it cannot be used to distinguish the histological grades of rectal cancer, nor other pathohistological parameters.
Exploring novel natural compound-based therapies for Duchenne muscular dystrophy management: insights from network pharmacology, QSAR modeling, molecular dynamics, and free energy calculations
Authors: Saeed Mohd , Haque Ashanul , Shoaib Ambreen , Danish Rizvi Syed Mohd
Published: October 2024

Muscular dystrophies encompass a heterogeneous group of rare neuromuscular diseases characterized by progressive muscle degeneration and weakness. Among these, Duchenne muscular dystrophy (DMD) stands out as one of the most severe forms. The present study employs an integrative approach combining network pharmacology, quantitative structure-activity relationship (QSAR) modeling, molecular dynamics (MD) simulations, and free energy calculations to identify potential therapeutic targets and natural compounds for DMD. Upon analyzing the GSE38417 dataset, it was found that individuals with DMD exhibited 290 upregulated differentially expressed genes (DEGs) compared to healthy controls. By utilizing gene ontology (GO) and protein-protein interaction (PPI) network analysis, this study provides insights into the functional roles of the identified DEGs, identifying ten hub genes that play a critical role in the pathology of DMD. These key genes include DMD, TTN, PLEC, DTNA, PKP2, SLC24A, FBXO32, SNTA1, SMAD3, and NOS1. Furthermore, through the use of ligand-based pharmacophore modeling and virtual screening, three natural compounds were identified as potential inhibitors. Among these, compounds 3874518 and 12314417 have demonstrated significant promise as an inhibitor of the SMAD3 protein, a crucial factor in the fibrotic and inflammatory mechanisms associated with DMD. The therapeutic potential of the compounds was further supported by molecular dynamics simulation and Molecular Mechanics/Generalized Born Surface Area (MM/GBSA) analysis. These findings suggest that the compounds are viable candidates for experimental validation against DMD.
Dihydromyricetin ameliorate postmenopausal osteoporosis in ovariectomized mice: Integrative microbiomic and metabolomic analysis
Authors: Xu Lei , Sun Xianze , Han Xiaoqiang , Li Hui , Li Xiaoqiong , Zhu Liying , Wang Xin , Li Jinjun , Sun Haibiao
Published: October 2024

The gut microbiota may help mitigate bone loss linked to postmenopausal osteoporosis by affecting the immune and inflammatory responses and the gut-bone axis. Dihydromyricetin (DMY), a natural flavonoid, has some anti-inflammatory and antioxidant properties. This study aimed to investigate the mechanisms underlying the amelioration of bone loss in ovariectomized (OVX) mice treated with various doses of DMY. Eight-week-old C57/BL6 mice underwent ovariectomy and received varying DMY doses over 8 weeks. Thereafter, femoral bone microarchitecture, serum biomarker levels, and colon samples were analyzed to assess bone metabolism and inflammatory and hormonal responses. Fecal samples were subjected to 16S rDNA sequencing, and short-chain fatty acids were quantified. An untargeted metabolomics approach was applied to both serum and fecal samples to investigate alterations in the intestinal microbiota and metabolic profiles following DMY treatment in the OVX mice. The results show high-dose DMY has anti-osteoporotic effects. Compared to the OVX group, the DMY-treated group showed enhanced bone mineral density and reduced inflammation and colonic damage levels. The DMY treatment altered the gut microbiota composition, including the relative abundances at both the phylum and genus levels. In addition, DMY treatment increased the production of acetate and propionate. Metabolomic analysis revealed differential regulation of 37 and 70 metabolites in the serum and feces samples, respectively, in the DMY-treated group compared to those in the OVX group, affecting the serotonergic signaling, arachidonic acid metabolism, and unsaturated fatty acid biosynthesis pathways. In conclusion, these findings indicate that DMY can ameliorate bone loss in OVX mice via the gut-bone axis.
Dehydroepiandrosterone suppresses human colorectal cancer progression through ER stress-mediated autophagy and apoptosis in a p53-independent manner
Authors: Nguyen Thi-Huong , Ko Huey-Jiun , Tsai Po-Yu , Cheng Tai-Shan , Tran Thu-Ha , Doan Ly Hien , Hsiao Michael , Chang Peter Mu-Hsin , Liu Hsiao-Sheng , Hong Yi-Ren , Huang Chi-Ying F.
Published: October 2024

Colorectal cancer (CRC) is one of the primary contributors to cancer-related fatalities, with up to 80% of advanced CRC cases exhibiting mutations in the p53 gene. Unfortunately, the development of new compounds targeting mutant p53 is quite limited. The anticancer effects of Dehydroepiandrosterone (DHEA) on various cancers have been reported. However, the suppressive effect of DHEA on CRC cells harboring wild-type or mutant p53 gene remains controversial. This study emphasized revealing the suppressive mechanism and the effect of DHEA on CRC cell tumorigenesis in the presence of wild-type or mutant p53 gene. We demonstrate that DHEA causes CRC cell death and cell cycle arrest in a dose and time-dependent manner. Notably, DHEA exhibits similar inhibitory effects on CRC cells regardless of the p53 gene status. Further study reveals that DHEA induces endoplasmic reticulum (ER) stress and triggers PERK/eIF2/ATF4/CHOP UPR signaling pathway to activate autophagy followed by apoptosis, which was confirmed by suppression of 4-phenylbutyric acid (an ER stress inhibitor) or knockdown either ATF4 or CHOP. DHEA-induced apoptosis was attenuated by silencing ATG5 gene in either p53+/+ or p53−/− CRC cells, indicating autophagy regulation of apoptosis. Furthermore, DHEA treatment accompanied by bafilomycin A1 (a blocker of autophagosome degradation) leads to the accumulation of ATF4, CHOP, DR5, and p21 levels in CRC cells, implying that the degradative autophagy machinery regulates these four molecules. Consistently, DHEA demonstrates its inhibitory effect by suppressing CRC tumor formation in vivo. Altogether, we provide compelling evidence that DHEA is a potential therapeutic candidate for CRC patient treatment regardless of the p53 status through ER stress-PERK-autophagy-apoptosis axis.
DNA methylation inhibitors adverse reaction characteristic analysis: a descriptive analysis from WHO-VigiAccess
Authors: Zhou Qiang , Xie Quanlei , Liu Qiang , Wang Haojie , Zhang Zhan , Yu Zhao , Guo Qian , Lin Jie
Published: October 2024

Introduction

DNA methylation inhibitors (azacitidine, decitabine) have revolutionized the treatment dilemma of myelodysplastic syndromes (MDS), a group of malignant hematopoietic disorders. This study evaluates the adverse drug reactions (ADRs) following the use of DNA methylation inhibitors in the World Health Organization (WHO) VigiAccess database and compares the characteristics of ADRs between the two drugs to select the drug with the minimum individualized risk for patients.

Methods

This study employed a retrospective descriptive analysis method. We compiled ADR reports for two marketed DNA methylation inhibitors for the treatment of MDS from WHO-VigiAccess. Data collected included demographic data such as age groups, gender, and regions of global patients covered by ADR reports, as well as data on the disease systems and symptoms caused by ADRs recorded in the annual reports and reports received by WHO. By calculating the proportion of ADRs reported for each drug, we compared the similarities and differences in ADRs between the two drugs.

Results

Overall, 23,763 adverse events (AEs) related to the two DNA methylation inhibitors were reported in VigiAccess. The results showed that the top 10 most common AEs were febrile neutropenia, bone marrow suppression, neutropenia, anemia, pancytopenia, leukopenia, thrombocytopenia, bone marrow failure, agranulocytosis, and hematotoxicity. The top five common types of DNA methylation inhibitor AEs were blood and lymphatic system disorders (11,178 cases, 47.0%), cardiac organ diseases (1,488 cases, 6.3%), various congenital familial genetic diseases (49 cases, 0.2%), ear and labyrinth diseases (100, 4.2%), and endocrine system diseases (57, 2.4%).

Conclusion

There is no Strong correlation between DNA methylation inhibitors and ADRs. Current comparative observational studies of these inhibitors show that there are common and specific adverse reactions in the ADR reports received by WHO for these drugs. Clinicians should improve the rational use of these drugs based on the characteristics of ADRs.
Hypoglycemic activity of Garcinia mangostana L. extracts on diabetes rodent models: A systematic review and network meta-analysis
Authors: Chatatikun Moragot , Tedasen Aman , Phinyo Phichayut , Wongyikul Pakpoom , Klangbud Wiyada Kwanhian , Kawakami Fumitaka , Imai Motoki , Chuaijit Sirithip , Rachmuangfang Sarawut , Phuwarinyodsakul Siriporn , Leelawattana Rattana , Phongphithakchai Atthaphong
Published: October 2024

Background

Diabetes mellitus is a significant global health issue, and alternative treatments from natural products like Garcinia mangostana L. [Clusiaceae] or GM are being explored for their potential benefits. This study focused on evaluating the hypoglycemic effects of GM on diabetic rodent models.

Methods

A comprehensive search was conducted in PubMed, Scopus, and Embase for studies reporting blood glucose levels within 2 weeks as the primary outcome and changes in total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) as secondary outcomes. A network meta-analysis (NMA) was performed to determine the pooled effectiveness of each intervention, estimating the weighted mean difference (WMD) and 95% confidence interval (CI) from both direct and indirect evidence. The surface under the cumulative ranking curve (SURCA) was used to rank the interventions.

Results

Ten articles were identified, with nine included for quantitative analysis. All GM extracts showed greater effectiveness than the control in decreasing blood glucose levels within 2 weeks. GM at 200 mg/kg (GM200) was the top-ranked extract for reducing glucose levels beyond 2 weeks and increasing HDL-C levels. The ethanol extract of GM at 200 mg/kg (GME200) was the most effective for blood glucose reduction within 2 weeks and for TC and TG reductions. The methanol extract of GM at 200 mg/kg (GMM200) was the top-ranked extract for LDL-C reductions.

Conclusion

GM and its extracts demonstrated significant hypoglycemic activity and improvements in lipid profiles in diabetic rodent models, highlighting their potential as therapeutic agents for the prevention and treatment of diabetes mellitus. Further research in human trials is warranted to confirm these findings and establish clinical applications.

Clinical trial registration

https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023426254.
Comparing single- and multi-post labeling delays for the measurements of resting cerebral and hippocampal blood flow for cerebrovascular testing in midlife adults
Authors: Decker Kevin P. , Sanjana Faria , Rizzi Nick , Kramer Mary K. , Cerjanic Alexander M. , Johnson Curtis L. , Martens Christopher R.
Published: October 2024

Objectives

To assess the reliability and validity of measuring resting cerebral blood flow (CBF) and hippocampal CBF using a single-post-labeling delay (PLD) and a multi-PLD pseudo-continuous arterial spin labeling (pCASL) protocol for cerebrovascular reactivity (CVR) testing.

Methods

25 healthy, midlife adults (57 ± 4 years old) were imaged in a Siemens Prisma 3T magnetic resonance imaging (MRI) scanner. Resting CBF and hippocampal CBF were assessed using two pCASL protocols, our modified single-PLD protocol (pCASL-MOD) to accommodate the needs for CVR testing and the multi-PLD Human Connectome Project (HCP) Lifespan protocol to serve as the reference control (pCASL-HCP). During pCASL-MOD, CVR was calculated as the change in CBF from rest to hypercapnia (+9 mmHg increase in end-tidal partial pressure of carbon dioxide [PETCO2]) and then normalized for PETCO2. The reliability and validity in resting gray matter (GM) CBF, white matter (WM) CBF, and hippocampal CBF between pCASL-MOD and pCASL-HCP protocols were examined using correlation analyses, paired t-tests, and Bland Altman plots.

Results

The pCASL-MOD and pCASL-HCP protocols were significantly correlated for resting GM CBF [r = 0.72; F (1, 23) = 25.24, p < 0.0001], WM CBF [r = 0.57; F (1, 23) = 10.83, p = 0.003], and hippocampal CBF [r = 0.77; F (1, 23) = 32.65, p < 0.0001]. However, pCASL-MOD underestimated resting GM CBF (pCASL-MOD: 53.7 ± 11.1 v. pCASL-HCP: 69.1 ± 13.1 mL/100 g/min; p < 0.0001), WM CBF (pCASL-MOD: 32.4 ± 4.8 v. pCASL-HCP: 35.5 ± 6.9 mL/100 g/min; p = 0.01), and hippocampal CBF (pCASL-MOD: 50.5 ± 9.0 v. pCASL-HCP: 68.1 ± 12.5 mL/100 g/min; p < 0.0001). PETCO2 increased by 8.0 ± 0.7 mmHg to induce CVR (GM CBF: 4.8% ± 2.6%; WM CBF 2.9% ± 2.5%; and hippocampal CBF: 3.4% ± 3.8%).

Conclusion

Our single-PLD pCASL-MOD protocol reliably measured CBF and hippocampal CBF at rest given the significant correlation with the multi-PLD pCASL-HCP protocol. Despite the lower magnitude relative to pCASL-HCP, we recommend using our pCASL-MOD protocol for CVR testing in which an exact estimate of CBF is not required such as the assessment of relative change in CBF to hypercapnia.
Assembly and comparative analysis of the first complete mitochondrial genome of Salix psammophila, a good windbreak and sand fixation shrub
Authors: Qiao Hongxia , Chen Yajuan , Wang Ruiping , Zhang Wei , Zhang Zhang , Yu Fengqiang , Yang Haifeng , Liu Guiming , Zhang Jiewei
Published: October 2024

Salix psammophila, commonly known as the sandlive willow, is a vital shrub species within the Salicaceae family, particularly significant for its ecological role in regions susceptible to desertification and sandy soils. In this study, we assembled the complete S. psammophila mitochondrial genome using Pacbio HiFi third-generation sequencing data. The genome was found to be a typical single circular structure, with a total length of 715,555 bp and a GC content of 44.89%. We annotated 33 unique protein-coding genes (PCGs), which included 24 core mitochondrial genes and 9 variable genes, as well as 18 tRNA genes (5 of which were multicopy genes) and 3 rRNA genes. Comparative analysis of the PCGs from the mitochondrial genomes of S. psammophila, Populus deltoides, Populus simonii, Salix wilsonii, and Salix suchowensis revealed that these genes are relatively conserved within the Salicaceae family, with variability primarily occurring in the ribosomal protein genes. The absence of the rps14, which encodes a ribosomal protein, may have played a role in the evolution of stress tolerance in Salicaceae plants. Additionally, we identified 232 SSRs, 19 tandem repeat sequences, and 236 dispersed repeat sequences in the S. psammophila mitochondrial genome, with palindromic and forward repeats being the most abundant. The longest palindromic repeat measured 260 bp, while the longest forward repeat was 86,068 bp. Furthermore, 324 potential RNA editing sites were discovered, all involving C-to-U edits, with the nad4 having the highest number of edits. These findings provide valuable insights into the phylogenetic and genetic research of Salicaceae plants.
Qualitative (pure) mathematics as an alternative to measurement
Authors: Linkov Václav
Published: October 2024

This paper focuses on the possible usage of qualitative mathematics in psychology. Qualitative mathematics is understood to be equivalent to pure mathematics. First, it is explained that mathematics is a discipline studying patterns in reproducible mental objects. Qualitative mathematics is presented as an alternative to measurement, potentially offering the same level of exactness, clarity, and rigor. This perspective might lead psychologists to explore connections between a phenomenon and any kind of mathematical structure, regardless of whether the structure is quantitative. Usage of (any) mathematical structures might require scholars who are familiar with them. Consequently, changes in mathematics education may also be needed. Introducing non-numerical structures into mathematics education—thereby partially revisiting the New Math Movement—could train individuals more prepared for a creative approach to the use of structures and less inclined to view everything as quantitative.
How technical and situational cues affect impulse buying behavior in social commerce? Evidence from bored consumers
Authors: Xue Yuhan , Feng Taiwen , Wu Chong
Published: October 2024

Introduction

With the rise of social media and web technologies, users are increasingly spending time on browsing and purchasing on social commerce, particularly during idle moments of casual scrolling. Social commerce applications with sophisticated social features and security measures may tend to attract a significant number of highly engaged users. The purpose of this study is to find out whether customers will be interested in the content posted on the applications and generate impulse consumption when they are bored.

Methods

Drawing on stimulus-organism-response framework, this paper explores how technical cues and situational cues affect impulse buying behavior in social commerce applications and the mediating impact of consumer-perceived values. Data were gathered from 395 respondents who frequently utilize and have shopping experience on social commerce applications. The PLS-SEM and fsQCA were applied to formulate and test the proposed hypotheses.

Results

The results of PLS-SEM reveal technical cues (ease of use, visual appeal and security) and situational cues (passing time and serendipity) positively influenced impulse buying. The results of fsQCA offer six solutions of different combinations of constructs which can lead to high impulse buying.

Discussion

These findings may extend existing research on impulse buying behavior and consumer psychology, offering valuable insights for marketers. They also point towards strategies for more effectively encouraging impulse purchase in digital retail environments, particularly among consumers who are browsing out of boredom.
Strategies and goals in Emotion Regulation models: a systematic review
Authors: Martínez-Priego Consuelo , García-Noblejas Belén Poveda , Roca Pablo
Published: October 2024

Introduction

Studies examining the role of Emotion Regulation (ER) do not consistently explain the underlying model or theory they are employing, resulting in a conflation of different strategies and goals within the ER scientific literature. This study aims to conduct a systematic review and conceptual analysis of the primary strategies and goals advocated in the ER models, theories, and frameworks. Furthermore, we explored the distinctions between the prevailing contemporary ER models and classical conceptions of emotional dynamics, such as those proposed by Aristotle, Descartes, and Darwin.

Methods

An electronic search was conducted in the Web of Science, Medline, and Scopus databases in November 2023. The key search terms used were grouped into two different topics: Emotion Regulation and Models/Theories/Frameworks. Articles were included if they reported one or more ER model in healthy individuals or emotionally disordered individuals and if they were published in a peer-reviewed journal in English in the last 5 years (from 2019 to 2023). A total of two reviewers independently assessed the titles, abstracts, and full texts. Models identified were summarized and classified based on the different ER strategies and goals.

Results

Of the 1,012 titles for initial consideration, 139 articles met the full eligibility criteria and were included for data extraction and synthesis. The review identified 10 ER models, and the most commonly used were the Process Model of Emotion Regulation and the Difficulties in Emotion Regulation. There was a great deal of homogeneity among the proposed ER strategies and goals: the cognitive dimension is the core of ER strategy, and the ER goals are primarily hedonic or instrumental in nature.

Discussion

Both Descartes and Darwin views were present in the ER models; however, some of the most significant contributions in Aristotelian proposal seem to be forgotten, such as the integration of the physical, operational, and growth dimensions (eudaimonic goals).

Systematic review registration

This systematic review was conducted in accordance with the PRISMA guidelines and was preregistered at Prospero platform (CRD42023491948).
Implicit motor imagery: examining motor vs. visual strategies in laterality judgments among older adults
Authors: Saran Aneet , Marotta Jonathan J.
Published: October 2024

Cognitive states like motor imagery (MI; simulating actions without overtly executing them) share a close correspondence with action execution, and hence, activate the motor system in a similar way. However, as people age, reduction in specific cognitive abilities like motor action simulation and action planning/prediction are commonly experienced. The present study examined the effect of visual–spatial processing for both typical and challenging upper-limb movements using the Hand Laterality Judgment Task (HLJT), in which participants were asked to judge whether the depicted hand is a left or right hand. Several main findings emerged: (1) Compared to younger adults, older adults exhibited slower responses and greater error rates in both Experiment 1 and 2. This suggests that visual–spatial transformations undergo alterations with age; (2) Older adults displayed higher error rates with realistic hands at both back and palm viewpoints of the hands compared to younger adults. However, this pattern did not hold for response times; (3) Participants responded faster to medial hand orientations (i.e., closer to the midline of the body) compared to lateral hand orientations (i.e., farther from the midline of the body) for palm-views in both Experiment 1 and Experiment 2. Given that we observed better performance on medial orientations compared to lateral orientations, this suggests that participants follow the same motor rules and biomechanical constraints of the represented movement. Novel information is provided about differences in individuals’ use of strategies (visual vs. motor imagery) to solve the HLJT for both mannequin and real hands.
Validation and psychometric evaluation of the French version of the recovery experience questionnaire: internal consistency and validity assessment
Authors: Le Moal Mathieu , Thurik Roy , Torrès Olivier
Published: October 2024

Background

Entrepreneurs often experience high levels of stress, anxiety, and burnout due to the demanding nature of their professional activities. Therefore, recovery from work-related stress is a relevant activity for entrepreneurs. The Recovery Experience Questionnaire (REQ) is a widely used 16-item self-reported measure covering four recovery factors: psychological detachment from work, relaxation, mastery, and control. The present study addresses the validation of a French version of the REQ.

Methods

A total of 1,043 French entrepreneurs from various sectors participated in this study. Internal consistency and correlations were examined to assess the psychometric properties of the French version of the REQ. Confirmatory factor analysis (CFA) was used to validate the four-factor structure of the REQ, with seven error covariances added to improve model fit.

Results

The French version of the REQ demonstrated good internal consistency (psychological detachment: α = 0.88, relaxation: α = 0.91, mastery: α = 0.90, control: α = 0.91). CFA supported that the four-factor structure was confirmed based on the following data: RMSEA = 0.071 (95% CI [0.066, 0.077]), CFI/TLI = 0.955/0.950, SRMR = 0.050, and χ2 (108) = 593.861, p < 0.001. Significant correlations were found between REQ scores and health indicators such as stress, loneliness, physical health, mental health, and sleep quality. The results confirm that the REQ is a valid and reliable measure for assessing recovery experiences among French entrepreneurs.

Conclusion

We conclude that the REQ is a valid measure and a useful tool for research on entrepreneurs’ general health. Additionally, the validated French version of the REQ can be applied to other working populations, making it a versatile instrument for evaluating health and recovery in diverse occupational settings. To support this claim, we conducted the same validation analysis on a sample of 1,231 French agricultural employees, again showing that REQ is a valid and reliable measure for assessing recovery experiences.
Ultrasound stimulation of the vagus nerve as a treatment modality for anxiety
Authors: Goyal Michell , Goyal Ravi , Sanguinetti Joseph L.
Published: October 2024

Anxiety is an increasingly prevalent mental disorder, causing widespread hardship and interfering with society’s economic progression. Standard treatments include various talk therapies with poor prognoses or drug interventions with complex side effects, both introducing unnecessary burdens to patients. To remedy this, non-invasive ultrasound stimulation to the vagus nerve is a novel, low-cost treatment that is showing promise. Although vagus nerve stimulation is already approved for epilepsy and other conditions, it requires regular maintenance. In contrast, studies using non-invasive ultrasound stimulation have shown preliminary positive results in affecting vagal activity with minimal drawbacks. This review covers a variety of studies investigating the effects of ultrasound stimulation on the vagus nerve. With rising levels of anxiety with each generation, there is a pressing need for more innovative and diverse treatments with fewer costs and more benefits.
The effect of juggling on the proprioceptive and attentional abilities among older women
Authors: Malik Jakub , Główka Natalia , Jelonek Wojciech , Maciaszek Janusz
Published: October 2024

Background

Age-related changes in attentional abilities can lead to a decline in body segment awareness in space. However, studies have reported that physical activity can improve proprioception among older adults, although proven activities with this potential are limited. Juggling is a promising activity for enhancing proprioception, as it requires high levels of attention and sensory precision. The first hypothesis posited that a juggling intervention would positively impact ipsilateral and contralateral elbow joint position matching without visual input. The second hypothesis suggested a correlation between cognitive abilities and joint position sense efficiency.

Methods

A total of 20 older women (mean age: 69.95 ± 4.58) participated in a repeated-measures study using a Latin square design. Measurements were taken at three time points (baseline, post-juggling, and control). Ipsilateral and contralateral elbow joint position matchings without visual or verbal feedback of accuracy were used to assess proprioception. Attention and reaction time variables were measured using the Vienna Test System protocols.

Results

Although significant changes were observed between baseline and subsequent time points in joint position sense accuracy, no specific effect of juggling was detected. Low and medium correlations were found between decision time and the variability of choice reaction time with contralateral accuracy. For ipsilateral accuracy, a relationship was observed only with handedness. No correlations were found between attention test scores and joint position sense accuracy.

Conclusion

The study did not demonstrate a significant effect of juggling on position-matching ability. However, cognitive abilities such as decision speed and the stability of choice reaction time may play a role in enhancing position-matching in older women.

Clinical trial registration

ClinicalTrials.gov, identifier NCT06108713.
Work stress and competency among radiology residents: the mediating effect of resilience
Authors: Shen Lijun , Lu Yuanmei , He Yanrong , Wang Peicheng , Chen Yanhua , Li Hange , Yang Zhenghan , Zhang Jingfeng , Wang Zhenchang , Jiang Maoqing , Zheng Jianjun , Zhu Jiming
Published: October 2024

Background

Competency of health professionals stands as a fundamental element in ensuring the quality of care. Notably, work stress and resilience are found to be associated with competency of health professionals. However, the role of resilience between work stress and competency remains unexplored. This study aims to investigate competency, work stress and resilience of radiology residents, and to examine the mediating effect of resilience.

Methods

A cross-sectional survey was conducted among 3,666 radiology residents from 31 provinces of China in 2021. The diagnostic radiology milestones were used to measure the competency. Results of work stress and resilience were derived from self-reports and assessment of the Connor Davidson Resilience Scale (CD-RISC) respectively. To examine the association between work stress, resilience, and competency, Spearman correlation analysis and hierarchical linear regression were employed. The mediating effect of resilience was tested by bootstrapping analysis.

Results

Descriptive statistics show that the average score (mean ± SD) of work stress, competency and resilience among radiology residents were 1.55 ± 1.53 (range from 0 to 6), 28.14 ± 13 (range from 0 to 81) and 5.97 ± 1.92 (range from 0 to 8), respectively. Work stress was negatively associated with competency (β = −0.51, p < 0.001) and resilience (−0.57, p < 0.001). In particular, resilience mediated the relationship between work stress and competence, and the total mediating effect was −0.49 (= − 0.57 * 0.86), accounting for 49.06% of the total effect.

Conclusion

Work stress is a significant contributor to competence among radiology residents. Resilience significantly mediated the association. This study highlights incorporating resilience training courses into the standardized residency training program to reduce intensive work stress and promote competency of radiology residents.
Towards a computational model for higher orders of Theory of Mind in social agents
Authors: Tavella Federico , Manzi Federico , Vinanzi Samuele , Di Dio Cinzia , Massaro Davide , Cangelosi Angelo , Marchetti Antonella
Published: October 2024

Effective communication between humans and machines requires artificial tools to adopt a human-like social perspective. The Theory of Mind (ToM) enables understanding and predicting mental states and behaviours, crucial for social interactions from childhood through adulthood. Artificial agents with ToM skills can better coordinate actions, such as in warehouses or healthcare. Incorporating ToM in AI systems can revolutionise our interactions with intelligent machines. This proposal emphasises the current focus on first-order ToM models in the literature and investigates the potential of creating a computational model for higher-order ToM.
Conceptual framework to incorporate drainage solutions in the urban open space system
Authors: Miguez Marcelo Gomes , Gomes Maria Vitória Ribeiro , Amback Beatriz Cruz , Mello Neto Hudson de , Thomaz Fernanda Rocha , Mattos Rodrigo Rinaldi de , Veról Aline Pires , Sousa Matheus Martins de , Rezende Osvaldo Moura , de Magalhães Paulo Canedo
Published: October 2024

Cities are increasingly dealing with challenges regarding the negative impact of rapid and mismanaged urbanization. Therefore, city planning must cope with the natural environment limitations, seeking a balance between the human activities and the well-functioning of the hydrologic cycle. This work aims to present a conceptual framework able to properly integrate the stormwater dynamics into the open spaces system in a functional way, establishing a Hydrological Interest Area, HIA, to structure urban expansion integrated into and respecting watershed natural processes. The initial step is to define a HIA, primarily consisting of open spaces that can be used for supporting urban drainage functions and to order land use in the urban expansion process. This delimitation offers the background for interpreting the watershed in three functional arches, especially covering the upstream, mid-reach and downstream areas of the basin, guiding the design of a set of flood mitigation interventions focusing on the use of Blue-Green Infrastructure. To illustrate and validate the proposed methodological framework, the design is evaluated by a flood modeling tool, using a hydrological-hydrodynamic cell-model. A case study was driven in the Bambu Watershed, a rapidly developing area in the municipality of Maricá, Rio de Janeiro, Brazil. The proposed intervention includes an urban expansion scenario for a low impact development on flood behavior alongside with four parks: an upstream park with reservoirs, two multifunctional floodable urban parks, and a park dedicated to lagoon restoration. This plan complements riverbed modifications designed to enhance water discharge. The simulation showed significant reduction of water depths with a consequent decrease in exposure of buildings and roads, especially in the most critical region of the watershed. This framework highlights the importance of a multifunctional approach in land use and serves as a robust foundation for controlling urban expansion and proposing projects.
Vertigo and dizziness due to vertebrobasilar TIA: a prospective study
Authors: Neto Arlindo C. Lima , Kim Ji-Soo , Bernardo Wanderley Marques , Bittar Roseli Saraiva Moreira
Published: October 2024

Purpose

Prospective studies on vascular vertigo and dizziness (VVD) due to vertebrobasilar transient ischemic attack (VBTIA) have been sparse. This study aimed to characterize clinical features, response to treatments, and prognostic factors of VVD due to VBTIA using a cohort established in 2021.

Methods

We recruited 103 patients (58 female individuals, 56.3%), with a mean age of 70.9 ± 9.3 years (range = 37–85), between January 2021 and January 2024. All patients met the diagnostic criteria of “Probable transient VVD” published by the Bárány Society. The mean interval from symptom onset to recruitment was 11.8 months (range = 0.5–72). Treatments followed the current American Heart Association–American Stroke Association's Guidelines for Prevention of Stroke in Patients with Stroke and Transient Ischemic Attack. Patients with recurrent strokes among TIAs, and patients who were already taking an antithrombotic agent and should maintain the same regimen were excluded.

Results

Imbalance (46.7%) and vertigo (39.8%) were the most frequent symptoms. The duration of attacks was <1 min in 35 patients (33.9%), 1–10 min in 34 patients (33.0%), 10–60 min in 15 patients (14.6%), and >60 min in 19 patients (18.5%). Trigger factors were reported in 20 patients (19.4%), which included eccentric neck position in 12 patients (11.7%), physical exercise in four patients (3.9%), positional changes in three patients (2.9%), and eccentric neck position and physical exercise in the remaining patient (0.9%). The frequency of attacks before the medication was 1 or <1/month in 32 (31.0%) patients, 1–4/month in 44 (42.7%) patients, 4–8/month in 21 patients (20.4%), and daily in six patients (5.9%). The treatment regimens were aspirin in 57 patients (55.3%), clopidogrel in 19 patients (18.5%), aspirin plus clopidogrel in 25 patients (24.3%), and rivaroxaban in two patients (1.9%). The attacks were reduced by 93.2% [IC 95% (88.34, 98.06), number needed to treat: 1] during the median follow-up of 12 months (range = 2–36 months). Only seven (6.8%) patients experienced a new attack with the medication. No prognostic factors could be identified for the recurrences.

Conclusion

VVD due to VBTIA has a broad clinical spectrum. Secondary stroke prevention is effective in VVD due to VBTIA even though no prognostic factors could be identified for symptom recurrence.
Microscopic Insect Pest Detection in Tea Plantations: Improved YOLOv8 Model Based on Deep Learning
Authors: Wang Zejun , Zhang Shihao , Chen Lijiao , Wu Wendou , Wang Houqiao , Liu Xiaohui , Fan Zongpei , Wang Baijuan
Published: October 2024

Pest infestations in tea gardens are one of the common issues encountered during tea cultivation. This study introduces an improved YOLOv8 network model for the detection of tea pests to facilitate the rapid and accurate identification of early-stage micro-pests, addressing challenges such as small datasets and the difficulty of extracting phenotypic features of target pests in tea pest detection. Based on the original YOLOv8 network framework, this study adopts the SIoU optimized loss function to enhance the model’s learning ability for pest samples. AKConv is introduced to replace certain network structures, enhancing feature extraction capabilities and reducing the number of model parameters. Vision Transformer with Bi-Level Routing Attention is embedded to provide the model with a more flexible computation allocation and improve its ability to capture target position information. Experimental results show that the improved YOLOv8 network achieves a detection accuracy of 98.16% for tea pest detection, which is a 2.62% improvement over the original YOLOv8 network. Compared with the YOLOv10, YOLOv9, YOLOv7, Faster RCNN, and SSD models, the improved YOLOv8 network has increased the mAP value by 3.12%, 4.34%, 5.44%, 16.54%, and 11.29%, respectively, enabling fast and accurate identification of early-stage micro pests in tea gardens. This study proposes an improved YOLOv8 network model based on deep learning for the detection of micro-pests in tea, providing a viable research method and significant reference for addressing the identification of micro-pests in tea. It offers an effective pathway for the high-quality development of Yunnan’s ecological tea industry and ensures the healthy growth of the tea industry.
Peripheral Population Status and Habitat Suitability Assessment of the Kiang (Equus kiang) on the Eastern Tibetan Plateau
Authors: Yang Shuai , Yang Yi , Feng Bin , Hu Lu , Dong Xin , Dong Huiqin , Bai Wenke
Published: October 2024

Shiqu County, Sichuan Province, forms the eastern edge of the distribution area of the kiang (Equus kiang). It is important to assess the population and habitat status of peripheral populations, as these play a significant role in the development of conservation strategies for kiangs. Based on field transect data collected from July to August 2023, this study predicted the suitable habitat distribution of kiangs in Shiqu County using a MaxEnt model and estimated the population size and density using the ‘Distance’ package. Additionally, it analyzed the responses of the group size of kiangs to environmental factors in Shiqu County. The results showed that the area of suitable habitat for kiangs is 3402.45 km2, accounting for 13.51% of the total area of Shiqu County. The estimated population was 1395.00 ± 272.20, with a population density of 0.41 ± 0.08/km2. Additionally, the group size of kiangs was significantly positively correlated with the distance from the road and grazing site. The distance from the grazing site, elevation, and temperature annual range are the main environmental factors affecting the distribution of kiangs. This study initially revealed the peripheral population Status and suitable habitat of the kiang on the eastern Tibetan Plateau, and the potential threat of grazing interference and road obstruction. The research results can provide a scientific reference for the population and habitat protection of kiangs in this area.