bluuebunny/crossref_metadata_2025 huggingface dataset:
Autonomous multicopter landing on a moving vehicle based on RSSI
Authors: An Jongwoo , Kang Hosun , Choi Jiwook , Lee Jangmyung
Published: February 2024

Currently, most of the studies on unmanned aerial vehicle (UAV) automatic landing systems mainly depend on image information to determine the landing location. However, the system requires a camera, a gimbal system and a separate image-processing device, which increases the weight and power consumption of the UAV, resulting in a shorter flight time. In addition, a large amount of computation and slow reaction speed can cause the camera to miss a proper landing moment. To solve these problems, in this study, the moving direction and relative distance between an object and the automatic landing system were measured using a receive signal strength indicator of the radio-frequency (RF) signal. To improve the movement direction and relative distance estimation accuracy, the noise in the RF signal was minimised using a low pass filter and moving average filter. Based on the filtered RF signal, the acceleration of the multicopter to reach the object was estimated by adopting the proportional navigation algorithm. The performance of the proposed algorithm for precise landing on a moving vehicle was demonstrated through experiments.
Mollusc and crustacean consumption in the first 1000 days: a scoping review
Authors: Oaks Brietta M. , Gyimah Emmanuel A. , Kleban Eliza , Ragsdale Kathleen , Iannotti Lora L.
Published: February 2024

Mollusc and crustacean consumption in the first 1000 d may improve maternal and child health by providing essential nutrients. However, in some contexts, molluscs and crustaceans have been associated with allergies and environmental contamination, potentially leading to adverse health and development outcomes. It is unclear whether the health benefits of consuming molluscs and crustaceans, collectively classified as shellfish in nutrition, are outweighed by the potential risks to pregnant women and children. We conducted a scoping review (PROSPERO: CRD42022320454) in PubMed, Scopus and EBSCO Global Health of articles published between January 2000 and March 2022 that assessed shellfish consumption during pregnancy, lactation or childhood (0–2 years) in relation to maternal health, child health or child development. A total of forty-six articles were included in this review. Overall, shellfish consumption was associated with higher biomarkers of environmental contaminants, with mercury being the most studied and having the strongest evidence base. The limited research on nutritional biomarker status shows an association between shellfish consumption and iodine status. Preterm birth was not associated with shellfish consumption, but newborn anthropometry showed mixed results, with several studies reporting lower birth weight with higher shellfish consumption. The few studies that examined child development and maternal health outcomes reported no significant associations. This review revealed trade-off health risks and benefits with inclusion of molluscs and crustaceans in the dietary patterns of mothers and young children. More research is needed to understand how these aquatic animal-source foods may be safely consumed and leveraged for improving human nutrition.
The Divorce Mill: Mercenary Citizenship in the Twilight of the Habsburg Empire
Authors: Reill Dominique Kirchner
Published: February 2024

This article analyses how wealthy men and women manipulated citizenship regimes during and after the Habsburg Empire to access the family laws most convenient for their private lives. To do this, I compare migratory divorce practices in pre-1918 Habsburg Hungary and the post-1918 Free State of Fiume. This article shows that while before 1918 it was mercenary actors who utilised legal loopholes between Austrian and Hungarian family laws and citizenship regulations to obtain divorces for the rich, after 1918 it was the impoverished, globally-isolated, mercenary postimperial state that procured the means for rich clients to buy their way out of their own state's family laws, raising questions about the relationship between the early twentieth-century postimperial world of globally dependent European successor states with today's postcolonial ‘golden passport’ system.
Language contexts induced by the interlocutors’ proficiencies modulate bilingual language monitoring
Authors: Kapiley Keerthana , Mishra Ramesh Kumar
Published: February 2024

Using a voluntary object-naming paradigm, we examined if bilinguals with high or low L2 proficiency monitor their language selection and production according to their interlocutors' L2 language proficiency. Telugu (L1)–English (L2) bilinguals were introduced to audio-visual stimuli that consisted of animated interlocutors that were high or low proficient in English. In Experiment 1, interlocutors were presented at different frequencies in each block, and in Experiment 2, the presentation of each interlocutor was blocked. We predicted that the frequency of interlocutors would modulate language activation and selection. The participants named the objects language that came to their minds to respond to interlocutors. Indeed, consistent with our predictions, monitoring contexts induced by such interlocutors influenced latencies, language choice and switch-cost. High-L2 proficient participants employed higher language control than low-L2 proficient participants. These results support the hypothesis that bilinguals are sensitive toward their interlocutors' language proficiency and employ context-appropriate cognitive control.
LGB+ identity and its implications for the policy positions of parliamentary candidates
Authors: Debus Marc , Wurthmann L. Constantin
Published: February 2024

Several studies concentrate on the representation of minority groups and the policy goals that members of these groups highlight when becoming candidates for public offices. However, we do not know much about the degree of parliamentary representation of sexual minorities and what ideological profile politicians with an LGB+ identity adopt. We aim at filling this gap by analysing the ideological stances of LGB+ candidates on key policy dimensions. Using data from the 2021 German candidate study, we find that the self-identification as LGB+ contributes significantly to adopting progressive stances on the socio-cultural dimension and more favourable positions on welfare state expansion, regardless of further important factors like party affiliation. Moreover, candidates who consider themselves LGB+ do take on significantly less traditional positions on the socio-cultural dimension compared to the position of their party, indicating that increasing descriptive representation of LGB+ individuals in parliament leads to a strengthening of more progressive voices in parliament and a stronger substantive representation of LGB+ interests.
Control of giant ragweed (Ambrosia trifida) in mesotrione-resistant soybean
Authors: Westrich Benjamin C. , Johnson William G. , Young Bryan G.
Published: February 2024

Preemergence applications of mesotrione, an herbicide that inhibits 4-hydroxyphenolpyruvate dioxygenase (HPPD), have recently gained regulatory approval in soybean varieties with appropriate traits. Giant ragweed is an extremely competitive broadleaf weed, and biotypes resistant to acetolactate synthase inhibitors (ALS-R) can be particularly difficult to manage with soil-residual herbicides in soybean production. This study investigated control of giant ragweed from preemergence applications of cloransulam (32 g ai ha–1), metribuzin (315 g ai ha–1), and S-metolachlor (1,600 g ai ha–1) in a factorial design with and without mesotrione (177 g ai ha–1) at two different sites over 2 yr. Treatments with mesotrione were also compared with two commercial premix products: sulfentrazone (283 g ai ha–1) and cloransulam (37 g ai ha–1), and chlorimuron (19 g ai ha–1), flumioxazin (69 g ai ha–1), and pyroxasulfone (87 g ai ha–1). At 42 d after planting, control and biomass reduction of giant ragweed were greater in treatments with mesotrione than any treatment without mesotrione. Giant ragweed biomass was reduced by 84% in treatments with mesotrione, whereas treatments without mesotrione did not reduce biomass relative to the nontreated. Following these preemergence applications, sequential herbicide treatments utilizing postemergence applications of glufosinate (655 g ai ha–1) plus fomesafen (266 g ai ha–1) and S-metolachlor (1,217 g ai ha–1) resulted in at least 97% control of giant ragweed at 42 d after planting, which was greater than sequential applications of glufosinate alone in 3 of 4 site-years. Preemergence applications of mesotrione can be an impactful addition to soybean herbicide programs designed to manage giant ragweed, with the potential to improve weed control and delay the onset of herbicide resistance by providing an additional effective herbicide site of action.
Barnyardgrass (Echinochloa crus-galli) control and rice injury with labeled herbicides following exposure to sublethal concentrations of paraquat
Authors: Sanders Tameka L. , Bond Jason A. , Allen Tom. W. , Gholson Drew , Krutz L. Jason , Webster Eric P.
Published: February 2024

Rice in Mississippi is often in early seedling growth stages when paraquat-based herbicide treatments are commonly applied to corn, cotton, and soybean; therefore, off-target movement of the herbicide onto adjacent rice fields may occur. After an off-target movement event has occurred, weed management in the rice crop is still necessary. Field studies were conducted from 2019 to 2021 in Stoneville, MS, to evaluate rice injury and barnyardgrass control with labeled herbicides after exposure to a sublethal concentration of paraquat. Herbicide treatments were label-recommended rates of imazethapyr, quinclorac, propanil, bispyribac-sodium, cyhalopfop, and florpyrauxifen-benzyl applied following rice exposure to a sublethal concentration of paraquat. Rice injury was detected 7 and 28 d after treatment (DAT) and was ≥35% and ≥14%, respectively, for all herbicides. Florpyrauxifen-benzyl and imazethapyr caused the greatest rice injury at 28 DAT. Following paraquat exposure, barnyardgrass control was similar for all labeled herbicide treatments at 7, 14, and 28 DAT except for florpyrauxifen-benzyl and no herbicide (paraquat alone) at 7 DAT. Across all evaluations, barnyardgrass control was at least 12% greater following paraquat exposure and labeled herbicide treatments than with no paraquat exposure. The current research demonstrates that labeled rates of herbicides applied following exposure to a sublethal concentration of paraquat resulted in <36% injury and provided as great as 95% control of barnyardgrass, depending on the herbicide treatment. Therefore, the labeled herbicides choice following rice exposure to a sublethal concentration of paraquat should be based on weed spectrum.
Confirmation and differential metabolism associated with quinclorac resistance in smooth crabgrass (Digitaria ischaemum)
Authors: Putri Atikah D. , Singh Varsha , de Castro Edicarlos B. , Rutland Claudia Ann , McElroy Joseph S. , Tseng Te-ming , McCurdy James D.
Published: February 2024

Quinclorac controls crabgrass (Digitaria spp.) in cool- and warm-season turfgrass species. Herbicide-resistant smooth crabgrass [Digitaria ischaemum (Schreb.) Schreb. ex Muhl.] biotypes have evolved due to recurrent usage of quinclorac. Two Mississippi populations (MSU1 and MSU2) of D. ischaemum were characterized using standard greenhouse dose–response screens to assess their resistance relative to known susceptible populations. Subsequent investigations explored mechanisms of resistance, including examining cyanide accumulation, glutathione S-transferase (GST) activity, and the potential involvement of cytochrome P450s in MSU1, MSU2, and a susceptible (SMT2). Resistant populations MSU1 and MSU2 required 80 and 5 times more quinclorac, respectively, to reach 50% biomass reduction than susceptible populations. The SMT2 biotype accumulated three times more cyanide than the resistant MSU1 and MSU2 populations. GST activity was elevated in resistant MSU1 and MSU2 populations. Furthermore, quinclorac concentrations in treated resistant populations were elevated when plants were pretreated with the P450 inhibitor malathion. These findings suggest a non–target site based mechanism of resistance involving the accumulation of cyanide. This may provide a scientific basis for understanding the occurrence of quinclorac-resistant D. ischaemum, although further research is needed to investigate potential target-site mechanisms of resistance.
A History of Chinese Musical Instrument Education in Toronto
Authors: CUI YAO
Published: February 2024

Whereas students in China can take Chinese instrument training in a variety of settings, Canada has no systematized structure of Chinese music education. Indeed, little scholarly attention has been paid to the development of Chinese instrumental music education in the Chinese diaspora within North America. Based on extensive fieldwork in Toronto, I address the following questions in this article: How do Chinese immigrants pass down their music? How and where do students take Chinese instrument training? How have the methods of transmission evolved? And how do Chinese instrument pedagogical techniques bridge Chinese and Canadian contexts?
Water Market Functionality: Evidence From the Australian Experience
Authors: Zhao Maruge , Ancev Tiho , Vervoort R. Willem
Published: February 2024

Market approaches to natural resource management have gained popularity over the last few decades. This study provides an encompassing analysis of the water market in the southern Murray‐Darling Basin (sMDB), Australia, in order to evaluate its performance and the importance of having various types of water rights traded in the market. We do so by investigating a set of market attributes, including price and price volatility, traded volume, number and the average size of transactions, and net import across a number of trading zones in the southern Murray‐Darling Basin. Our findings show that the price mechanism in the water market functions as intended, as the water prices signal the level of scarcity and reflect value that can be derived from water resources. Other factors like crop structure and institutional settings also play important roles in explaining differences in water market outcomes across the considered trading zones within the sMDB market. Overall, our findings document that water markets serve well their fundamental purpose in water resource management to allocate water toward its economically‐highest‐valued uses, and that various types of water rights traded in the market are meeting heterogenous needs of market participants in managing water supply and use.
2D Near‐Surface Full‐Waveform Tomography Reveals Bedrock Controls on Critical Zone Architecture
Authors: Eppinger B. J. , Holbrook W. S. , Liu Z. , Flinchum B. A. , Tromp J.
Published: February 2024

For decades, seismic imaging methods have been used to study the critical zone, Earth's thin, life‐supporting skin. The vast majority of critical zone seismic studies use traveltime tomography, which poorly resolves heterogeneity at many scales relevant to near‐surface processes, therefore limiting progress in critical zone science. Full‐waveform tomography can overcome this limitation by leveraging more seismic data and enhancing the resolution of geophysical imaging. In this study, we apply 2D full‐waveform tomography to match the phases of observed seismograms and elucidate previously undetected heterogeneity in the critical zone at a well‐studied catchment in the Laramie Range, Wyoming. In contrast to traveltime tomograms from the same data set, our results show variations in depth to bedrock ranging from 5 to 60 m over lateral scales of just tens of meters and image steep low‐velocity anomalies suggesting hydrologic pathways into the deep critical zone. Our results also show that areas with thick fractured bedrock layers correspond to zones of slightly lower velocities in the deep bedrock, while zones of high bedrock velocity correspond to sharp vertical transitions from bedrock to saprolite. By corroborating these findings with borehole imagery, we hypothesize that lateral changes in bedrock fracture density majorly impact critical zone architecture. Borehole data also show that our full‐waveform tomography results agree significantly better with velocity logs than previously published traveltime tomography models. Full‐waveform tomography thus appears unprecedentedly capable of imaging the spatially complex porosity structure crucial to critical zone hydrology and processes.
Toward a US Framework for Continuity of Satellite Observations of Earth's Climate and for Supporting Societal Resilience
Authors:   KISS Continuity Study Team
Published: February 2024

There is growing urgency for improved public and commercial services to support a resilient, secure, and thriving United States (US) in the face of mounting decision‐support needs for environmental stewardship and hazard response, as well as for climate change adaptation and mitigation. Sustained space‐based Earth observations are critical infrastructure to support the delivery of science and decision‐support information with local, national, and global utility. This is reflected in part through the United States' sustained support of a suite of weather and land‐imaging satellites. However, outside of these two areas, the US lacks an overarching, systematic plan or framework to identify, prioritize, fund, and implement sustained space‐based Earth observations to meet the Nation's full range of needs for science, government policy, and societal support. To aid and accelerate the discussion on our nation's needs, challenges and opportunities associated with sustained critical space‐based Earth observations, the Keck Institute for Space Studies (KISS) sponsored a multi‐week think‐tank study to offer ways forward. Based on this study, the KISS study team suggests the establishment of a robust coordination framework to help address US needs for sustained Earth observations. This coordination framework could account for: (a) approaches to identify and prioritize satellite observations needed to meet US needs for science and services, (b) the rapidly evolving landscape of space‐based Earth viewing architecture options and technology improvements with increasing opportunities and lower cost access to space, and (c) the technical and programmatic underpinnings required for proper and comprehensive data stewardship to support a wide range of research and public services.
Climate Change Will Impact Surface Water Extents and Dynamics Across the Central United States
Authors: Vanderhoof Melanie K. , Christensen Jay R. , Alexander Laurie C. , Lane Charles R. , Golden Heather E.
Published: February 2024

Climate change is projected to impact river, lake, and wetland hydrology, with global implications for the condition and productivity of aquatic ecosystems. We integrated Sentinel‐1 and Sentinel‐2 based algorithms to track monthly surface water extent (2017–2021) for 32 sites across the central United States (U.S.). Median surface water extent was highly variable across sites, ranging from 3.9% to 45.1% of a site. To account for landscape‐based differences (e.g., water storage capacity, land use) in the response of surface water extents to meteorological conditions, individual statistical models were developed for each site. Future changes to climate were defined as the difference between 2006–2025 and 2061–2080 using MACA‐CMIP5 (MACAv2‐METDATA) Global Circulation Models. Time series of climate change adjusted surface water extents were projected. Annually, 19 of the 32 sites under RCP4.5 and 22 of the 32 sites under RCP8.5 were projected to show an average decline in surface water extent, with drying most consistent across the southeast central, southwest central, and midwest central U.S. Projected declines under surface water dry conditions at these sites suggest greater impacts of drought events are likely in the future. Projected changes were seasonally variable, with the greatest decline in surface water extent expected in summer and fall seasons. In contrast, many north central sites showed a projected increase in surface water in most seasons, relative to the 2017–2021 period, likely attributable to projected increases in winter and spring precipitation exceeding increases in projected temperature.
Impacts of Carbonate Buffering on Atmospheric Equilibration of CO2, δ13CDIC, and Δ14CDIC in Rivers and Streams
Authors: Winnick Matthew J. , Saccardi Brian
Published: February 2024

Rivers and streams play an important role within the global carbon cycle, in part through emissions of carbon dioxide (CO2) to the atmosphere. However, the sources of this CO2 and their spatiotemporal variability are difficult to constrain. Recent work has highlighted the role of carbonate buffering reactions that may serve as a source of CO2 in high alkalinity systems. In this study, we seek to develop a quantitative framework for the role of carbonate buffering in the fluxes and spatiotemporal patterns of CO2 and the stable and radio‐ isotope composition of dissolved inorganic carbon (DIC). We incorporate DIC speciation calculations of carbon isotopologues into a stream network CO2 model and perform a series of simulations, ranging from the degassing of a groundwater seep to a hydrologically‐coupled 5th‐order stream network. We find that carbonate buffering reactions contribute >60% of emissions in high‐alkalinity, moderate groundwater‐CO2 environments. However, atmosphere equilibration timescales of CO2 are minimally affected, which contradicts hypotheses that carbonate buffering maintains high CO2 across Strahler orders in high alkalinity systems. In contrast, alkalinity dramatically increases isotope equilibration timescales, which acts to decouple CO2 and DIC variations from the isotopic composition even under low alkalinity. This significantly complicates a common method for carbon source identification. Based on similar impacts on atmospheric equilibration for stable and radio‐ carbon isotopologues, we develop a quantitative method for partitioning groundwater and stream corridor carbon sources in carbonate‐dominated watersheds. Together, these results provide a framework to guide fieldwork and interpretations of stream network CO2 patterns across variable alkalinities.
Controls on Mineral Formation in High pH Fluids From the Lost City Hydrothermal Field
Authors: Aquino Karmina A. , Früh‐Green Gretchen L. , Bernasconi Stefano M. , Bontognali Tomaso R. R. , Foubert Anneleen , Lang Susan Q.
Published: February 2024

Although the serpentinite‐hosted Lost City hydrothermal field (LCHF) was discovered more than 20 years ago, it remains unclear whether and how the presence of microbes affects the mineralogy and textures of the hydrothermal chimney structures. Most chimneys have flow textures comprised of mineral walls bounding paleo‐channels, which are preserved in inactive vent structures to a varying degree. Brucite lines the internal part of these channels, while aragonite dominates the exterior. Calcite is also present locally, mostly associated with brucite. Based on a combination of microscopic and geochemical analyses, we interpret brucite, calcite, and aragonite as primary minerals that precipitate abiotically from mixing seawater and hydrothermal fluids. We also observed local brucite precipitation on microbial filaments and, in some cases, microbial filaments may affect the growth direction of brucite crystals. Brucite is more fluorescent than carbonate minerals, possibly indicating the presence of organic compounds. Our results point to brucite as an important substrate for microbial life in alkaline hydrothermal systems.
Orbital Controls on North Pacific Dust Flux During the Late Quaternary
Authors: Zhong Yi , Liu Yanguang , Yang Hu , Yin Qiuzhen , Wilson David J. , Lu Zhengyao , Jaccard Samuel L. , Struve Torben , Clift Peter D. , Kaboth‐Bahr Stefanie , Larrasoaña Juan C. , Bahr André , Gong Xun , Zhao Debo , Zhang Yanan , Xia Wenyue , Liu Qingsong
Published: February 2024

Airborne mineral dust is sensitive to climatic changes, but its response to orbital forcing is still not fully understood. Here, we present a reconstruction of dust input to the Subarctic Pacific Ocean covering the past 190 kyr. The dust composition record is indicative of source moisture conditions, which were dominated by precessional variations. In contrast, the dust flux record is dominated by obliquity variations and displays an out‐of‐phase relationship with a dust record from the mid‐latitude North Pacific Ocean. Climate model simulations suggest precession likely drove changes in the aridity and extent of dust source regions. Additionally, the obliquity variations in dust flux can be explained by meridional shifts in the North Pacific westerly jet, driven by changes in the meridional atmospheric temperature gradient. Overall, our findings suggest that North Pacific dust input was primarily modulated by orbital‐controlled source aridity and the strength and position of the westerly winds.
Spatial and Temporal Patterns of Southern Ocean Ventilation
Authors: Styles Andrew F. , MacGilchrist Graeme A. , Bell Michael J. , Marshall David P.
Published: February 2024

Ocean ventilation translates atmospheric forcing into the ocean interior. The Southern Ocean is an important ventilation site for heat and carbon and is likely to influence the outcome of anthropogenic climate change. We conduct an extensive backwards‐in‐time trajectory experiment to identify spatial and temporal patterns of ventilation. Temporally, almost all ventilation occurs between August and November. Spatially, “hotspots” of ventilation account for 60% of open‐ocean ventilation on a 30 years timescale; the remaining 40% ventilates in a circumpolar pattern. The densest waters ventilate on the Antarctic shelf, primarily near the Antarctic Peninsula (40%) and the west Ross sea (20%); the remaining 40% is distributed across East Antarctica. Shelf‐ventilated waters experience significant densification outside of the mixed layer.
Spatiotemporal Characteristics of Tectonic Tremors in the Collisional Orogen of Taiwan
Authors: Ide Satoshi , Chen Kate Huihsuan
Published: February 2024

Taiwan offers a distinctive tectonic setting as a collisional orogen, ideal for studying tectonic tremors and the slow deformation process in the mountain‐building process. Using continuous seismic data at many stations, which have become available recently, and employing the envelope correlation method, we detected ∼7,000 tremor events from 2012 to 2022, with waveform characteristics similar to tectonic tremors worldwide. Beyond the previously known tremor zone beneath the southern Central Range, where newly detected tremors align along a low‐angle thrust plane, we identified several new tremor “hotspots” spanning 200 km along the mountain belt. These hotspots are situated at the termination of the subducting slabs and around the deep (25–50 km) extension of the Central Range fault, where repeating earthquakes occur at a depth of 10–25 km. Our findings suggest a strong linkage between the tremor generation mechanism and the mountain‐building process, potentially influenced by underground fluid and temperature anomalies.
Phase‐Locked Rossby Wave‐4 Pattern Dominates the 2022‐Like Concurrent Heat Extremes Across the Northern Hemisphere
Authors: Yang Xiaoye , Zeng Gang , Zhang Shiyue , Iyakaremye Vedaste , Shen Cheng , Wang Wei‐Chyung , Chen Deliang
Published: February 2024

Concurrent heat extremes (CHEs) are becoming increasingly common in the mid‐high latitudes across the Northern Hemisphere (NH), underscoring the need to comprehend their spatiotemporal characteristics and underlying causes. Here we reveal a phase‐locking behavior in Wave‐4 pattern, particularly after mid‐1990s, giving rise to a prominent CHE mode akin to heat extreme pattern observed in 2022, which swept most NH regions. Wave‐4 pattern significantly amplifies the likelihood of CHEs in Eastern Europe (∼30%), Northeast Asia (∼25%), and northwestern coast of North America (∼15%), while reducing the likelihood in central North America and northern Central Asia. During 1979–2022, the identified pattern accounted for over 69.7% of the trends in heat extremes over the mid‐high latitudes of the NH, directly exposing approximately 333.5 million people to heat extremes. Observations and simulations indicate that radiation anomalies over Eastern European Plain and West Siberian Plain play pivotal roles as primary forcing sources for Wave‐4 pattern.
Airborne Observations Constrain Heterogeneous Nitrogen and Halogen Chemistry on Tropospheric and Stratospheric Biomass Burning Aerosol
Authors: Decker Zachary C. J. , Novak Gordon A. , Aikin Kenneth , Veres Patrick R. , Neuman J. Andrew , Bourgeois Ilann , Bui T. Paul , Campuzano‐Jost Pedro , Coggon Matthew M. , Day Douglas A. , DiGangi Joshua P. , Diskin Glenn S. , Dollner Maximilian , Franchin Alessandro , Fredrickson Carley D. , Froyd Karl D. , Gkatzelis Georgios I. , Guo Hongyu , Hall Samuel R. , Halliday Hannah , Hayden Katherine , Holmes Christopher D. , Jimenez Jose L. , Kupc Agnieszka , Lindaas Jakob , Middlebrook Ann M. , Moore Richard H. , Nault Benjamin A. , Nowak John B. , Pagonis Demetrios , Palm Brett B. , Peischl Jeff , Piel Felix M. , Rickly Pamela S. , Robinson Michael A. , Rollins Andrew W. , Ryerson Thomas B. , Schill Gregory P. , Sekimoto Kanako , Thompson Chelsea R. , Thornhill Kenneth L. , Thornton Joel A. , Ullmann Kirk , Warneke Carsten , Washenfelder Rebecca A. , Weinzierl Bernadett , Wiggins Elizabeth B. , Williamson Christina J. , Winstead Edward L. , Wisthaler Armin , Womack Caroline C. , Brown Steven S.
Published: February 2024

Heterogeneous chemical cycles of pyrogenic nitrogen and halides influence tropospheric ozone and affect the stratosphere during extreme Pyrocumulonimbus (PyroCB) events. We report field‐derived N2O5 uptake coefficients, γ(N2O5), and ClNO2 yields, φ(ClNO2), from two aircraft campaigns observing fresh smoke in the lower and mid troposphere and processed/aged smoke in the upper troposphere and lower stratosphere (UTLS). Derived φ(ClNO2) varied across the full 0–1 range but was typically <0.5 and smallest in a PyroCB (<0.05). Derived γ(N2O5) was low in agricultural smoke (0.2–3.6 × 10−3), extremely low in mid‐tropospheric wildfire smoke (0.1 × 10−3), but larger in PyroCB processed smoke (0.7–5.0 × 10−3). Aged biomass burning aerosol in the UTLS had a higher γ(N2O5) of 17 × 10−3 that increased with sulfate and liquid water, but that was 1–2 orders of magnitude lower than values for aqueous sulfuric aerosol used in stratospheric models.
Statistical Studies of Plasma Structuring in the Auroral Ionosphere by the Swarm Satellites
Authors: Buschmann L. M. , Clausen L. B. N. , Spicher A. , Ivarsen M. F. , Miloch W. J.
Published: February 2024

This study uses over 2 years of 16 Hz density measurements, 50 Hz magnetic field data and ROTI data from the Swarm mission to perform long term statistics of plasma structuring in the polar ionosphere. The timeframe covers more than 2 years near the 24th solar cycle peak. We additionally use 3 years of data obtained from a timeframe close to solar minimum for discussion. We present power spectral densities (PSD) of electron density irregularities and magnetic field for 1‐min intervals. These PSD have been characterized by the probability of a slope steepening, and by integrating the power deposited within frequency intervals corresponding to kilometer scales. For the electron density, we observe seasonal dependencies for both the integrated power and slope characteristics. While the dual slope probability, especially within the polar cap, varies with solar EUV‐radiation, the integrated power is strongest around the equinoxes. Additionally, while we found similar results for the slope probability for both hemispheres, the integrated power exhibits strong hemispheric asymmetries with stronger enhancements within local summer in the southern hemisphere. The ROTI data shows a similar seasonal variability as the density PSD integrated power, in both seasonal dependency and interhemispheric variability. However, for the ROTI data the strongest fluctuations were found within the nightside auroral oval and the cusp. For the PSD of the magnetic field data, we obtain the strongest enhancements within the cusp for all seasons and all hemispheres. The fluctuations may indicate an increase in Alfvénic energy associated with a downward Poynting flux.
Simulations and Prediction of Historical and Future Maximum Freeze Depth in the Northern Hemisphere
Authors: Chen Cong , Peng Xiaoqing , Frauenfeld Oliver W. , Chu Xinde , Chen Guanqun , Huang Yuan , Li Xuanjia , Yang Guangshang , Tian Weiwei
Published: February 2024

The maximum annual freeze depth (MFD) is a primary indicator of the thermal state of frozen ground, affecting ecosystems, hydrological processes, vegetation growth, infrastructure, and human activities in cold regions. It is thus important to quantify the past, present, and future spatial and temporal variability of MFD at the hemispheric scale. We develop a data‐driven MFD simulation method within a machine learning framework, integrating MFD observations from meteorological stations and several environmental predictors, to analyze past and future scenarios in the Northern Hemisphere (NH). Based on ERA5 reanalysis estimates and historical to future CMIP6 scenarios, the NH MFD averaged 133 cm (ERA5) and 131 cm (CMIP6) during 1981–2010, and will vary 81–112 cm during 2015–2100 depending on the emission scenario. During 1950–2013, MFD decreased by 0.37 cm/a (ERA5) versus 0.22 cm/a (CMIP6), and is projected to decrease 0.16–0.69 cm/a by 2100. During 1981–2010, MFD decreased by an average of 19.1% (ERA5) and 13.9% (CMIP6), with a net change of −17 cm (ERA5) and −13 cm (CMIP6). Depending on the emission scenario, MFD will decrease 11% (−12 cm) to 42% (−19 cm) between 2015 and 2099 relative to the 1981–2010. Warming, increased moisture, warmer cold seasons, warmer warm seasons, shallower snow depths, and increased vegetation cover all lead to a reduction in MFD. The results from this novel machine learning approach provide useful insights regarding the fate of future frozen ground changes.
Lake Water Temperature Modeling in an Era of Climate Change: Data Sources, Models, and Future Prospects
Authors: Piccolroaz S. , Zhu S. , Ladwig R. , Carrea L. , Oliver S. , Piotrowski A. P. , Ptak M. , Shinohara R. , Sojka M. , Woolway R. I. , Zhu D. Z.
Published: February 2024

Lake thermal dynamics have been considerably impacted by climate change, with potential adverse effects on aquatic ecosystems. To better understand the potential impacts of future climate change on lake thermal dynamics and related processes, the use of mathematical models is essential. In this study, we provide a comprehensive review of lake water temperature modeling. We begin by discussing the physical concepts that regulate thermal dynamics in lakes, which serve as a primer for the description of process‐based models. We then provide an overview of different sources of observational water temperature data, including in situ monitoring and satellite Earth observations, used in the field of lake water temperature modeling. We classify and review the various lake water temperature models available, and then discuss model performance, including commonly used performance metrics and optimization methods. Finally, we analyze emerging modeling approaches, including forecasting, digital twins, combining process‐based modeling with deep learning, evaluating structural model differences through ensemble modeling, adapted water management, and coupling of climate and lake models. This review is aimed at a diverse group of professionals working in the fields of limnology and hydrology, including ecologists, biologists, physicists, engineers, and remote sensing researchers from the private and public sectors who are interested in understanding lake water temperature modeling and its potential applications.
Controlling Factors of Evapotranspiration Predictability Under Diverse Climates With the Effects of Water Storage Change in the Budyko Framework
Authors: Wu Chuanhao , Yeh Pat J.‐F. , Zhou Jun , Li Jiayun , Zhong Lulu , Wang Saisai , Gong Zhengjie , Shi Min , Ju Jiali , Huang Guoru
Published: February 2024

The Budyko models (BM) have been extended in previous studies by incorporating water storage change (ΔS) (subtracting ΔS from precipitation) to estimate evapotranspiration (ET) under non‐steady state conditions at scales finer than the climatological mean scale. However, a systematic assessment of the interannual ET predictability of the extended BM is still lacking, hence its validity and controlling factors of improvement (over the original BM) under globally diverse climates is not yet well understood. Based on a long‐term (1984–2008) gridded water budget data set, we present a comparative analysis of annual ET predictability between the original BM (ET1) and the extended BM considering ΔS (ET2) in 32 global river basins to explore the sensitivity of climate factors and catchment hydrologic responses in determining ET predictability. Results show that the difference between ET1 and ET2 increases linearly with ΔS, with ET2 < ET1 (ET2 > ET1) when ΔS > 0 (ΔS < 0). When both ET1 and ET2 overestimate (underestimate) observed ET, the error in ET2 is smaller than ET1 when ΔS > 0 (ΔS < 0) for all 32 basins considered. When the error signs of ET2 and ET1 differ, however, the difference in the absolute magnitude of ET2 and ET1 errors (REdiff) under extremely humid climates is determined by the difference between potential ET and ET, leading to comparable accuracy between ET2 and ET1. In contrast, under extremely arid climates, REdiff is controlled by the combined influences of ΔS and R, resulting in more accurate ET2 than ET1 under the condition of the in‐phase, positive‐correlated relationship between ΔS and R.
Rural Water Point Functionality Estimates and Associations: Evidence From Nine Countries in Sub‐Saharan Africa and South Asia
Authors: Murray Anna L. , Stone Gabriela , Yang Audrey R. , Lawrence Nicholas F. , Matthews Hannah , Kayser Georgia L.
Published: February 2024

Sustained functionality of rural water systems is a global challenge. Research on factors contributing to rural water system functionality is largely restricted to hand pumps from single geographies. We analyzed monitoring data from 10 drinking water supply programs in nine sub‐Saharan African and South Asian countries collected between 2017 and 2020. Data included 1,805 randomly selected water points (tap stands, spring protections, rainwater collection, and boreholes and hand‐dug wells with hand pumps) from two cross‐sectional samples: older construction (1–12 years old) and new construction (<1 year). Data collection included observations of water point functionality (“water available”) and management committee questionnaires. Overall, 79% of older construction and 92% of new construction water points were functional. In a mixed effects logistic regression to identify factors contributing to functionality within the older construction sample, piped water tap stands had lower odds of functioning than boreholes with hand pumps (OR = 0.26, 95% CI:0.15–0.46). Water points in communities with fewer available water points, those with operational water management committees (which meet often, collect fees, and can name someone for maintenance), and those with financial savings were associated with higher functionality. As piped water system provision increases in line with international development goals, our results suggest that the benefits of providing higher levels of water service should be carefully considered alongside the technological, institutional, and financial investment required to operate and maintain more complex piped water systems in rural settings.
Concentrations of remdesivir and GS-441524 in human milk from lactating individuals diagnosed with COVID-19
Authors: Bertrand Kerri , Sepulveda Yadira , Spiegel Benjamin J. , Best Brookie M. , Suhandynata Raymond , Rossi Steven , Chambers Christina D. , Momper Jeremiah D.
Published: February 2024

Impact

Findings from this study provide further reassuring evidence that infant exposure through human milk received from lactating individuals who require treatment with remdesivir is negligible.
The endogenous opioid system in the medial prefrontal cortex mediates ketamine’s antidepressant-like actions
Authors: Jiang Cheng , DiLeone Ralph J. , Pittenger Christopher , Duman Ronald S.
Published: February 2024

Recent studies have implicated the endogenous opioid system in the antidepressant actions of ketamine, but the underlying mechanisms remain unclear. We used a combination of pharmacological, behavioral, and molecular approaches in rats to test the contribution of the prefrontal endogenous opioid system to the antidepressant-like effects of a single dose of ketamine. Both the behavioral actions of ketamine and their molecular correlates in the medial prefrontal cortex (mPFC) are blocked by acute systemic administration of naltrexone, a competitive opioid receptor antagonist. Naltrexone delivered directly into the mPFC similarly disrupts the behavioral effects of ketamine. Ketamine treatment rapidly increases levels of β-endorphin and the expression of the μ-opioid receptor gene (Oprm1) in the mPFC, and the expression of gene that encodes proopiomelanocortin, the precursor of β-endorphin, in the hypothalamus, in vivo. Finally, neutralization of β-endorphin in the mPFC using a specific antibody prior to ketamine treatment abolishes both behavioral and molecular effects. Together, these findings indicate that presence of β-endorphin and activation of opioid receptors in the mPFC are required for the antidepressant-like actions of ketamine.
Haplotype phasing of CYP2D6: an allelic ratio method using Agena MassARRAY data
Authors: Thamilselvan Megana , Mather Cheryl , Wang Yabing , Foo Jerome C. , Aitchison Katherine J.
Published: February 2024

Pharmacogenomics aims to use the genetic information of an individual to personalize drug prescribing. There is evidence that pharmacogenomic testing before prescription may prevent adverse drug reactions, increase efficacy, and reduce cost of treatment. CYP2D6 is a key pharmacogene of relevance to multiple therapeutic areas. Indeed, there are prescribing guidelines available for medications based on CYP2D6 enzyme activity as deduced from CYP2D6 genetic data. The Agena MassARRAY system is a cost-effective method of detecting genetic variation that has been clinically applied to other genes. However, its clinical application to CYP2D6 has to date been limited by weaknesses such as the inability to determine which haplotype was present in more than one copy for individuals with more than two copies of the CYP2D6 gene. We report application of a new protocol for CYP2D6 haplotype phasing of data generated from the Agena MassARRAY system. For samples with more than two copies of the CYP2D6 gene for which the prior consensus data specified which one was present in more than one copy, our protocol was able to conduct CYP2D6 haplotype phasing resulting in 100% concordance with the prior data. In addition, for three reference samples known to have more than two copies of CYP2D6 but for which the exact number of CYP2D6 genes was unknown, our protocol was able to resolve the number for two out of the three of these, and estimate the likely number for the third. Finally, we demonstrate that our method is applicable to CYP2D6 hybrid tandem configurations.
Deubiquitinase Mysm1 regulates neural stem cell proliferation and differentiation by controlling Id4 expression
Authors: Xu Zhenhua , Qin Qiaozhen , Wang Yan , Zhang Heyang , Liu Shuirong , Li Xiaotong , Chen Yue , Wang Yuqing , Ruan Huaqiang , He Wenyan , Zhang Tao , Yan Xinlong , Wang Changyong , Xu Donggang , Jiang Xiaoxia
Published: February 2024

Neural stem cells (NSCs) are critical for brain development and maintenance of neurogenesis. However, the molecular mechanisms that regulate NSC proliferation and differentiation remain unclear. Mysm1 is a deubiquitinase and is essential for the self-renewal and differentiation of several stem cells. It is unknown whether Mysm1 plays an important role in NSCs. Here, we found that Mysm1 was expressed in NSCs and its expression was increased with age in mice. Mice with Mysm1 knockdown by crossing Mysm1 floxed mice with Nestin-Cre mice exhibited abnormal brain development with microcephaly. Mysm1 deletion promoted NSC proliferation and apoptosis, resulting in depletion of the stem cell pool. In addition, Mysm1-deficient NSCs skewed toward neurogenesis instead of astrogliogenesis. Mechanistic investigations with RNA sequencing and genome-wide CUT&Tag analysis revealed that Mysm1 epigenetically regulated Id4 transcription by regulating histone modification at the promoter region. After rescuing the expression of Id4, the hyperproliferation and imbalance differentiation of Mysm1-deficient NSCs was reversed. Additionally, knockdown Mysm1 in aged mice could promote NSC proliferation. Collectively, the present study identified a new factor Mysm1 which is essential for NSC homeostasis and Mysm1-Id4 axis may be an ideal target for proper NSC proliferation and differentiation.
Increased thrombospondin-1 levels contribute to epileptic susceptibility in neonatal hyperthermia without seizures via altered synaptogenesis
Authors: Zhai Yujie , Cheng Yao , Yuan Yi , Meng Xianfeng , Li Yang , Wang Yan , Ren Tianpu , Li Shucui , Sun Hongliu
Published: February 2024

Childhood febrile seizures (FS) represent one of the most common types of seizures and may lead to severe neurological damage and an increased risk of epilepsy. However, most children with fevers do not show clinical manifestations of convulsions, and the consequences of hyperthermia without seizures remain elusive. This study focused on hyperthermia not reaching the individual’s seizure threshold (sub-FS stimulus). Changes in thrombospondin-1 (TSP-1) levels, synapses, seizure susceptibility, and seizure severity in subsequent FS were investigated in rats exposed to sub-FS stimuli. Pharmacological and genetic interventions were used to explore the role of TSP-1 in sub-FS-induced effects. We found that after sub-FS stimuli, the levels of TSP-1 and synapses, especially excitatory synapses, were concomitantly increased, with increased epilepsy and FS susceptibility. Moreover, more severe neuronal damage was found in subsequent FS. These changes were temperature dependent. Reducing TSP-1 levels by genetic intervention or inhibiting the activation of transforming growth factor-β1 (TGF-β1) by Leu-Ser-Lys-Leu (LSKL) led to lower synapse/excitatory synapse levels, decreased epileptic susceptibility, and attenuated neuronal injury after FS stimuli. Our study confirmed that even without seizures, hyperthermia may promote synaptogenesis, increase epileptic and FS susceptibility, and lead to more severe neuronal damage by subsequent FS. Inhibition of the TSP-1/TGF-β1 pathway may be a new therapeutic target to prevent detrimental sub-FS sequelae.