bluuebunny/crossref_metadata_2025 huggingface dataset:
A Model for an Online Program Preparing Rural Directors of Special Education and Pupil Services
Authors: Dempsey Stephen D. , Stephens J. Todd
Published: July 2017

This article describes a model in special education personnel preparation designed to respond to needs in rural areas for fully licensed Director of Special Education and Pupil Services administrators. The program utilizes a fully online course format and also requires participants to complete a supervised practicum in their school districts. Rigorous admission requirements and extensive involvement of retired or presently employed Directors of Special Education maintain quality and have allowed for efficiency in this state approved program. This program has graduated over 60 candidates across 3 years.
A Toolkit for Web-Based Course Creation and Conversion
Authors: Floyd Kimberly , Hughes Kimberly , Maydosz Ann
Published: July 2017

Web-based instruction is not a new phenomenon. There are 15–20 years of research and literature to support the effectiveness of web-based instruction. The purpose of this article is to synthesize the research in this field in order to determine which factors are critical to the success of web-based instruction. We created a toolkit to assist instructors in creating web-based instruction. First, we attest that one must be aware of web-based students’ performance. Second, social presence should be established through discussion forums and collaborative activities. Third, teacher presence should be moderated. Fourth, web-based courses should base course content in project-based learning activities. Fifth, a web-based instructor must provide optimal feedback. Empirical evidence is cited to support each of the five “tools.”
The relative utilities of genome-wide, gene panel, and individual gene sequencing in clinical practice
Authors: Kuo Frank C. , Mar Brenton G. , Lindsley R. Coleman , Lindeman Neal I.
Published: July 2017

Advances in technology that have transpired over the past 2 decades have enabled the analysis of cancer samples for genomic alterations to understand their biologic function and to translate that knowledge into clinical practice. With the power to analyze entire genomes in a clinically relevant time frame and with manageable costs comes the question of whether we ought to and when. This review focuses on the relative merits of 3 approaches to molecular diagnostics in hematologic malignancies: indication-specific single gene assays, gene panel assays that test for genes selected for their roles in cancer, and genome-wide assays that broadly analyze the tumor exomes or genomes. After addressing these in general terms, we review specific use cases in myeloid and lymphoid malignancies to highlight the utility of single gene testing and/or larger panels.
RETRACTED ARTICLE: Increased Aβ42-α7-like nicotinic acetylcholine receptor complex level in lymphocytes is associated with apolipoprotein E4-driven Alzheimer’s disease pathogenesis
Authors: Wang Hoau-Yan , Trocmé-Thibierge Caryn , Stucky Andres , Shah Sanket M. , Kvasic Jessica , Khan Amber , Morain Philippe , Guignot Isabelle , Bouguen Eva , Deschet Karine , Pueyo Maria , Mocaer Elisabeth , Ousset Pierre-Jean , Vellas Bruno , Kiyasova Vera
Published: July 2017

Background

The apolipoprotein E ε4 (APOE4) genotype is a prominent late-onset Alzheimer’s disease (AD) risk factor. ApoE4 disrupts memory function in rodents and may contribute to both plaque and tangle formation.

Methods

Coimmunoprecipitation and Western blot detection were used to determine: 1) the effects of select fragments from the apoE low-density lipoprotein (LDL) binding domain and recombinant apoE subtypes on amyloid beta (Aβ)42-α7 nicotinic acetylcholine receptor (α7nAChR) interaction and tau phosphorylation in rodent brain synaptosomes; and 2) the level of Aβ42-α7nAChR complexes in matched controls and patients with mild cognitive impairment (MCI) and dementia due to AD with known APOE genotypes.

Results

In an ex vivo study using rodent synaptosomes, apoE141–148 of the apoE promotes Aβ42-α7nAChR association and Aβ42-induced α7nAChR-dependent tau phosphorylation. In a single-blind study, we examined lymphocytes isolated from control subjects, patients with MCI and dementia due to AD with known APOE genotypes, sampled at two time points (1 year apart). APOE ε4 genotype was closely correlated with heightened Aβ42-α7nAChR complex levels and with blunted exogenous Aβ42 effects in lymphocytes derived from AD and MCI due to AD cases. Similarly, plasma from APOE ε4 carriers enhanced the Aβ42-induced Aβ42-α7nAChR association in rat cortical synaptosomes. The progression of cognitive decline in APOE ε4 carriers correlated with higher levels of Aβ42-α7nAChR complexes in lymphocytes and greater enhancement by their plasma of Aβ42-induced Aβ42-α7nAChR association in rat cortical synaptosomes.

Conclusions

Our data suggest that increased lymphocyte Aβ42-α7nAChR-like complexes may indicate the presence of AD pathology especially in APOE ε4 carriers. We show that apoE, especially apoE4, promotes Aβ42-α7nAChR interaction and Aβ42-induced α7nAChR-dependent tau phosphorylation via its apoE141–148 domain. These apoE-mediated effects may contribute to the APOE ε4-driven neurodysfunction and AD pathologies.
Characterisation of preparation layers in nine Danish Golden Age canvas paintings by SEM–EDX, FTIR and GC–MS
Authors: Andersen C. K. , Bonaduce I. , Andreotti A. , van Lanschot J. , Vila A.
Published: July 2017

This study explores the materials used in the preparation layers of nine paintings from the Danish Golden Age as a first approach to understanding the variation in use of materials in the nineteenth century as well as the potential for their degradation. Paintings on canvas have traditionally been suspected to be particularly sensitive to high moisture levels because of the changing quality of materials in the nineteenth century. The explanations have partly included the mechanisation of production methods and partly a more experimental approach to painting. Additionally, collagen-based glue sizing of the canvas is suspected to respond dimensionally to changes in relative humidity. In this study, pigments, fillers and binding media in the preparation layers of nine paintings by different artists were identified using scanning electron microscopy with energy dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy and gas chromatography–mass spectrometry. The study shows a relatively low degree of variation in materials used in grounds. Surprisingly, no collagen-based binder was found in any of the nine paintings, suggesting that the canvases were not glue sized. All paintings contained calcium, lead, a drying oil and egg, even though only few contemporary recipes in painter’s manuals included egg as an ingredient for preparation layers. These results suggest that the commercial producers of prepared canvas may not have followed the manuals that were written for painters. Egg may have been added in order to increase flexibility and durability of ready primed canvases that were stored and sold in rolls. Moreover, the egg–oil emulsion has the advantage of being more viscous than a pure oil paint and could thus be used without sizing the canvas, rendering the primed canvas less stiff and less responsive to changes in relative humidity. The advantages of using egg in the ground are obvious, and this use, as well as the lack of glue size, has implications for the long-term preservation of the paintings in changing environmental conditions. These results imply that these particular paintings might be less sensitive to relative humidity changes than expected due to the lack of hygroscopic glue.
Improving Exam Performance in Introductory Biology through the Use of Preclass Reading Guides
Authors: Lieu Rebekah , Wong Ashley , Asefirad Anahita , Shaffer Justin F.
Published: July 2017

High-structure courses or flipped courses require students to obtain course content before class so that class time can be used for active-learning exercises. While textbooks are used ubiquitously in college biology courses for content dissemination, studies have shown that students frequently do not read their textbooks. To address this issue, we created preclass reading guides that provided students with a way to actively engage with the required reading for each day of class. To determine whether reading guide completion before class is associated with increased performance, we surveyed students about their use of reading guides in two sections of a large-enrollment (400+ students) introductory biology course and used multiple linear regression models to identify significant correlations. The results indicated that greater than 80% of students completed the reading guides before class and that full completion of the reading guides before class was significantly positively correlated with exam performance. Reading guides in most cases were used similarly between different student groups (based on gender, ethnicity, and aptitude). These results suggest that optional preclass reading guides may help students stay on track to acquire course content in introductory biology and thus result in improved exam performance.
Increasing Research Productivity in Undergraduate Research Experiences: Exploring Predictors of Collaborative Faculty–Student Publications
Authors: Morales Danielle X. , Grineski Sara E. , Collins Timothy W.
Published: July 2017

Little attention has been paid to understanding faculty–student productivity via undergraduate research from the faculty member’s perspective. This study examines predictors of faculty–student publications resulting from mentored undergraduate research, including measures of faculty–student collaboration, faculty commitment to undergraduate students, and faculty characteristics. Generalized estimating equations were used to analyze data from 468 faculty members across 13 research-intensive institutions, collected by a cross-sectional survey in 2013/2014. Results show that biomedical faculty mentors were more productive in publishing collaboratively with undergraduate students when they worked with students for more than 1 year on average, enjoyed teaching students about research, had mentored Black students, had received more funding from the National Institutes of Health, had a higher H-index scores, and had more years of experience working in higher education. This study suggests that college administrators and research program directors should strive to create incentives for faculty members to collaborate with undergraduate students and promote faculty awareness that undergraduates can contribute to their research.
Microbeam radiation therapy — grid therapy and beyond: a clinical perspective
Authors: Schültke Elisabeth , Balosso Jacques , Breslin Thomas , Cavaletti Guido , Djonov Valentin , Esteve Francois , Grotzer Michael , Hildebrandt Guido , Valdman Alexander , Laissue Jean
Published: July 2017

Microbeam irradiation is spatially fractionated radiation on a micrometer scale. Microbeam irradiation with therapeutic intent has become known as microbeam radiation therapy (MRT). The basic concept of MRT was developed in the 1980s, but it has not yet been tested in any human clinical trial, even though there is now a large number of animal studies demonstrating its marked therapeutic potential with an exceptional normal tissue sparing effect. Furthermore, MRT is conceptually similar to macroscopic grid based radiation therapy which has been used in clinical practice for decades. In this review, the potential clinical applications of MRT are analysed for both malignant and non-malignant diseases.
Ribonucleoprotein purification and characterization using RNA Mango
Authors: Panchapakesan Shanker Shyam S. , Ferguson Matthew L. , Hayden Eric J. , Chen Xin , Hoskins Aaron A. , Unrau Peter J.
Published: July 2017

The characterization of RNA–protein complexes (RNPs) is a difficult but increasingly important problem in modern biology. By combining the compact RNA Mango aptamer with a fluorogenic thiazole orange desthiobiotin (TO1-Dtb or TO3-Dtb) ligand, we have created an RNA tagging system that simplifies the purification and subsequent characterization of endogenous RNPs. Mango-tagged RNP complexes can be immobilized on a streptavidin solid support and recovered in their native state by the addition of free biotin. Furthermore, Mango-based RNP purification can be adapted to different scales of RNP isolation ranging from pull-down assays to the isolation of large amounts of biochemically defined cellular RNPs. We have incorporated the Mango aptamer into the S. cerevisiae U1 small nuclear RNA (snRNA), shown that the Mango-snRNA is functional in cells, and used the aptamer to pull down a U1 snRNA-associated protein. To demonstrate large-scale isolation of RNPs, we purified and characterized bacterial RNA polymerase holoenzyme (HE) in complex with a Mango-containing 6S RNA. We were able to use the combination of a red-shifted TO3-Dtb ligand and eGFP-tagged HE to follow the binding and release of the 6S RNA by two-color native gel analysis as well as by single-molecule fluorescence cross-correlation spectroscopy. Together these experiments demonstrate how the Mango aptamer in conjunction with simple derivatives of its flurophore ligands enables the purification and characterization of endogenous cellular RNPs in vitro.
THE TECTONO - STRATIGRAPHIC EVOLUTION OF PINDOS FORELAND EAST OF MESOLONGI
Authors: Noti A. , Tserolas P. , Maravelis A. , Zelilidis A.
Published: July 2017

Sedimetological analysis of submarine fan deposits, both north and south of Evinos River, east of Mesolongi town, showed that there are different sedimentological conditions. The southern part outcropped between Klokova and Varasova Mountains, influenced by Gavrovo thrust activity, is characterized by coarse grained inner fan deposits, and sourced both from Pindos chain and the uplifted Klokova and Varasova Mountains. Gavrovo thrust activity, took place during the sedimentation producing intrabasinal highs, changing basin geometry. In the northern part, where outer fan deposits passes upwards to inner fans, there is no obvious influence of Gavrovo thrust but mostly the influence of internal Ionian Thrust. Between the two studied areas there is a high deformed area, about 1km wide, trending parallel to the Evinos River in a ENE direction, showing that probable Evinos River flows on a strike-slip fault.
VOLCANIC HAZARD ASSESSMENT AT SANTORINI VOLCANO: A REVIEW AND A SYNTHESIS IN THE LIGHT OF THE 2011-2012 SANTORINI UNREST
Authors: Vougioukalakis G. , Sparks R.S. , Druitt T. , Pyle D. , Papazachos C. , Fytikas M.
Published: July 2017

In 2011 and the first half of 2012 Santorini experienced its first seismo-volcanic unrest since 1950, as detected by the permanently installed monitoring networks and a large number of campaign measurements. The unrest was characterized by small magnitude but intense seismic activity, significant uplift and inflation deformation rates, and changes of water temperature as well as of fluid and soil gases. While the unrest ended in the spring of 2012, the world-wide interest led to the performance of several studies, in an attempt to assess the possible scenarios for the unrest evolution. Within this framework, we summarize the most important findings regarding the volcanic hazard assessment of the broader Santorini volcanic complex, as well as the constraints that need to be taken into account for a possible future volcanic crisis management.
SOIL EROSION ESTIMATION USING THE EPM MODEL
Authors: Efthimiou N. , Lykoudi E.
Published: July 2017

The study aims to evaluate soil erosion and investigate its spatial distribution by applying the empirical EPM (i.e. Erosion Potential Model) at mountainous Mediterranean type catchments. Study area includes the catchments of Venetikos; Kalamas; Upper Acheloos and Arachthos Rivers (eight subcatchments in total), very important aquatic systems of NW Greece. The model was implemented both annually and inter-annually. A GIS-based approach was adopted, considering the spatial variation of its factors, as well as the erosion processes occurring in a catchment. The results were initially validated by being compared to the observed sediment yield values (based on the sediment discharge measurements conducted by the PPC). The model’s performance was poor, significantly underestimating the results at both time scales. The ambiguous reliability of the PPC measurements led to their replacement by simulated ones, estimated using the sediment discharge rating curves methodology. Regarding the latter, the model performed better, attributing more accurate results, yet anew underestimated. However, it managed to identify the most susceptible to erosion areas. The poor performance is mainly attributed to its inherent shortcomings along with the specific characteristics and sedimentary regime of the study area.
STUDY OF BEACHROCKS IN EAST ATTICA
Authors: Karkani A. , Evelpidou N. , Maroukian H. , Kawasaki S.
Published: July 2017

Sea level indicators, such as tidal notches and beachrocks, may provide valuable information for the relative sea level changes of an area. Beachrocks in particular have received various arguments concerning their use as reliable sea level indicators and their formation environment. This work focuses on the coasts of East Attica in order to trace the palaeoshorelines of the Upper Holocene through the study of beachrocks. The coastal zone was surveyed in detail by snorkelling and diving, in order to locate, map and sample beachrocks. The samples were studied under a SEM, which showed that the beachrocks are mainly composed of quartz grains, a few calcites and feldspars, while the carbonate cement is characterized with the presence of MgO at percentages between 5 and 7.8%. Based on correlations with published drillings in the study area, the studied beachrocks should not be older than 2000 years BP.
GEOCHEMICAL CHARACTERISTICS OF THE GEOTHERMAL FLUIDS IN THE AKROPOTAMOS AREA (MACEDONIA, NORTHERN GREECE)
Authors: Arvanitis A. , Dotsika E. , Kolios N.
Published: July 2017

The geothermal field of Akropotamos produces fluids at temperatures up to 90oC. The waters from wells AKR-1, AKR-3, AKR-4, AKR-5 and AKR-6 at 30 86oC and TDS of 3.1-30.7 g/l are classified as Na-Cl type. The water from well AKR-2 at 46oC with TDS of 2.15 g/l belongs to Na-HCO3Cl type. The cold and sub-thermal waters (16.4- 27oC) in the area are considered as fresh or low salinity waters (TDS: 0.31-4.34 g/l) of various mixed types. The Na-Cl geothermal waters can be divided into two categories due to two different hot aquifers: (a) Τhe first shallow aquifer contains high salinity waters (TDS: 27.4 30.7 g/l) at 30-48oC located within sands, sandstones and gravels. (b) Τhe second deeper reservoir composed of calcareous conglomerates and sandstones contains lower salinity waters (TDS: 3.1-5.08 g/l) at 83-90οC. The contribution of seawater to the chemical composition of the thermal waters in the shallow aquifer system seems to be important. With the aid of chemical geothermomometers applied to the geothermal water from well AKR-1, the deep temperature has been estimated to be >120oC. Significant quantities of CO2 are encountered in wells AKR-1 and AKR-3.
MAPPING AND CLASSIFICATION OF DIRECT EFFECTS OF THE FLOOD OF OCTOBER 2014 IN ATHENS
Authors: Diakakis M. , Deligiannakis G. , Katsetsiadou K. , Lekkas E. , Melaki M. , Antoniadis Z.
Published: July 2017

In 24 October 2014, a high intensity storm hit Athens’ western suburbs causing extensive flash flooding phenomena. The drainage and the sewerage network of the city were overwhelmed leading to catastrophic flood flows along the road network, flooding houses and businesses, sweeping away vehicles, injuring people and causing numerous problems in transportation across the city. Parts of the city were inundated for several hours, particularly in western Athens, namely Ilion, Menidi, Peristeri, Acharnai, Korydallos and Piraeus. This work examines and reconstructs in detail the flood's characteristics, the different types of direct effects within the urban environment and the severity of its direct impacts across Athens basin. Results show a concentration of flood damages in specific locations mostly along the city's natural drainage network or derelict streams and culverts. At their peak stage, floodwaters extended to an area of 4.9 square km recording a maximum depth of 170 cm in certain locations. Eight types of direct impacts were identified in 1223 impact locations, including effects on vegetation, geomorphology, erosion, mobile objects, buildings, infrastructure and human population. A severity scale was developed allowing effects to be divided in five severity classes across the flooded area and making possible the delineation of high impact sections of the city.
KINEMATIC ANALYSIS EVOLUTION OF EXTENDED LANDSLIDES: TWO CASE STUDIES FROM WESTERN GREECE
Authors: Kavoura K. , Anagnostopoulou S. , Servou K. , Depoundis N. , Nikolakopoulos K. , Sabatakakis N.
Published: July 2017

Two of the most well known historical landslide occurrences are analyzed and their temporal evolution is presented. The sites of Panagopoula and Karya are often referred as the most representative cases of long term ground displacements based on inclinometer monitoring data. Regarding these cases, the heavy rainfalls constitute the main controlling (triggering) factor, while flysch is the critical landslide-prone formation which significantly contributes to landsliding. The inclinometer data through a long time period were analyzed and typical movement diagrams were compiled. A simple statistical model including data normalization through several active stages (phases) of movement is used to identify the common kinematic features as well as to estimate the velocity trend type of movement.
CORRELATIONS BETWEEN PHYSICAL PROPERTIES AND POINT LOAD STRENGTH INDEX OF PRASINITES: A CASE STUDY FROM EAST ATTICA PREFECTURE
Authors: Kotsanis D. , Nomikos P.P. , Rozos D. , Sofianos A.I.
Published: July 2017

The aim of this study is to investigate the statistical correlations between the point load strength index and certain physical properties, e.g. the dry density and the dry longitudinal ultrasonic wave velocity of prasinites (metabasites). Statistically significant correlations established between the physical properties as well as between each physical quantity and the point load strength index. According to bibliography, this is one of the first efforts to develop relations between physical and mechanical properties for this particular petrological type, and therefore the derived equations can be a useful tool to the investigation of these petrological types, either in the study area or in other sites, where prasinites of similar structural characteristics, are examined for the foundation of various constructions.
ENGINEERING GEOLOGICAL CHARACTERISATION OF BLOCK-IN-MATRIX ROCKS
Authors: Nikolaidis G. , Saroglou C.
Published: July 2017

Block-in-matrix rocks (“bimrocks”) are complex, mixed and heterogeneous formations of competent blocks embedded in weaker matrix. The inherent difficulty of sampling and consequently, laboratory testing of bimrocks leads to considerable challenging in geotechnical design and assessment of their engineering behaviour. An approach for the characterisation of “bimrocks” is the use of stereological analysis that extrapolates one-dimensional or two dimensional data to estimate the block volumetric proportion. This has been an established approach of dealing with bimrocks and melanges for the last two decades. This paper presents the parameters that are considered important for the engineering characterisation of such complex formations, while a case study from a bimrock in NW Greece is discussed.
SEAWATER INTRUSION AND NITRATE POLLUTION IN COASTAL AQUIFER OF MARATHON BASIN
Authors: Papazotos P. , Koumantakis I. , Vasileiou E.
Published: July 2017

The overexploitation of groundwater and groundwater salinization cause quantitative and qualitative degradation of the water resources. The objectives of this research are to identify and investigate the extent of seawater intrusion and nitrate pollution into the coastal plain of Marathon in Eastern Attica, Greece. In the frame of this, 25 groundwater samples were collected in October 2014 from the study area and analyzed regarding the main parameters that indicated salinization of the aquifers. Specifically, water chemical analyses were carried out and statistical analyses regarding spatial distribution were performed. The results demonstrated increased values of the parameters which can be associated with seawater intrusion. Considering and evaluating the results from the chemical analyses it is obvious that seawater intrusion takes place in the area. Furthermore, the average concentration of NO3- was 44.16mg L-1 and this can be attributed to overexploitation of coastal aquifer for agricultural activities.
MINERALOGICAL COMPOSITION OF SUSPENDED PARTICLES PM10 IN THE PTOLEMAIS-KOZANI AREA, MACEDONIA, GREECE
Authors: Nikolaidou P. , Triantafyllou A. , Kantiranis N. , Filippidis A.
Published: July 2017

PM10 suspended particles were collected from the Kardia lignite mine (July 2009), the the campus of Technological Education Institution of Western Macedonia (December 2010) and the Kozani city centre (August 2005). The mineralogical composition and the amorphous materials content of the samples was determined by X-Ray Powder Diffraction method. All samples contain amorphous materials (43-66wt.%), calcite (13-37 wt.%), micas + clays (4-9 wt.%) and quartz (2-8 wt.%), while in three samples feldspars (2-11 wt.%) were detected. Anhydrite, which is a constituent of the fly ash and the bottom ash, was detected (6 wt.%) only in one sample from the area of Kardia mine. Gypsum was detected, in the Kardia mine (2 and 3 wt.%), in the Kozani city centre (8 wt.%) and in the University campus (13 and 14 wt.%). Gypsum is a constituent of the mined lignite, the stack-gas ash and the Saharan dust. That explains the higher concentrations of gypsum in the University campus on1st and 2nd of December 2010, where the influence of Saharan dust on the atmospheric particulate matter levels in Western Macedonia was reported.
THE ACCELEROMETRIC NETWORK OF THE INDES-MUSA PROJECT IN THE KALOCHORI AREA: CONFIGURATION, DOCUMENTATION AND PRELIMINARY DATA INTERPRETATION
Authors: Rovithis E. , Makra K. , Savvaidis A. , Kirtas E.
Published: July 2017

A network of seven accelerometric stations on both ground surface and structures has been recently installed, as part of a multi-sensor network for monitoring seismic motion and ground subsidence in the broader area of Kalochori, west of Thessaloniki in Northern Greece, within the INDES-MUSA project. This network includes ground installations within the urban area, structural stations on top of structures and a freefield station away from the building stock. The documentation of stations is presented including shear wave velocity profiles of the subsoil at each location. A set of thirtynine earthquakes recorded so far by the accelerometric network is reported, followed by data processing procedures performed in the acquired waveforms. Comparisons of the processed earthquake recordings are presented referring to (a) the urbanground and the free-field stations in terms of peak ground acceleration, indicating amplification trends of ground motion, and (b) the structural and the nearby urban ground stations by means of top-to-base ratios in the frequency domain, towards a preliminary identification of the fundamental vibrational characteristics of the instrumented structures. The processed acceleration data are available through the INDES-MUSA Web-GIS portal.
LOCAL EARTHQUAKE TOMOGRAPHY IN THE BROADER AREA OF WESTERN CORINTH GULF
Authors: Karakonstantis A. , Papadimitriou P.
Published: July 2017

In this study, we applied Local Earthquake Tomography in order to investigate the detailed 3-D structure within and around the broader region of Western Corinth Gulf which is one of the most seismically active regions in the world. We use data from the 2012-2014 time-period, selecting about 2,000 seismic events recorded by the local seismic stations of Hellenic Unified Seismological Network (HUSN) and the Corinth Rift Laboratory Network (CRLN). Applying Tomographic Inversion, we produce and interpret 3-D models of Vp, Vs and Vp/Vs ratio in the study area. The obtained results shows several distinct structures, namely areas of high and low Vp/Vs ratio correlating the hypocenter distribution with changes in lithology or fluid concentration. In the area of Patraikos Gulf, an ascending velocity volume was traced that could possibly be connected to salt tectonics in the alpine basement, effecting the fluid circulation as well as the behavior of local faults.
SOME PRELIMINARY RESULTS ON THE DISTRIBUTION OF AFTERSHOCK SEQUENCES IN JAPAN-KURIL ISLANDS AND KAMCHATKA
Authors: Olasoglou E.M. , Tsapanos T.M. , Papadimitriou E.E. , Drakatos G.N.
Published: July 2017

study on the aftershock sequences distributed along the subductions in Japan and Kuril islands, as well as in Kamchatka is undertaken. Aftershock sequences, having a main shock magnitude Mw >7.0, during the time period 1973-2013 are taken into account. The data used (mainshocks, aftershocks and foreshocks if there are any) are restricted in shallow focal depths. A large earthquake in Japan Trench (11 March 2011 / Mw=9.0) occurred and for this reason the investigated area is of particular interest. Our study is concentrated on the spatial distribution of some parameters [Mc, a, b (Gutenberg-Richter distribution) and p, c, k (Omori’s law)] closely associated with the seismic sequences statistics.
A HOMOGENEOUS EARTHQUAKE CATALOG OF INTERMEDIATE-DEEP FOCUS GLOBAL SEISMICITY: COMPLETENESS AND SPATIO-TEMPORAL ANALYSIS
Authors: Tsampas A.D. , Scordilis E.M. , Papazachos C.B. , Karakaisis G.F.
Published: July 2017

homogeneous with respect to magnitude earthquake catalog is compiled, particularly focusing on the global intermediate depth-deep focus seismicity and by exploiting data of almost half-century. Within a two-step compilation process, we take advantage of 10 robust conversion equations produced exclusively for intermediate depth and deep focal data (Tsampas et al., 2016). Initially, magnitudes of different scales and several origins are converted into proxy moment magnitudes (Mw*~Mw) and a weighted mean-value aggregation procedure is then applied for all events with estimated Mw*. Therefore, a homogeneous magnitude scale (equivalent to Mw) is obtained as result of individual correlations between different magnitude scales and the moment magnitude (Mw) scale, yielding a unique magnitude value per event. Moreover, through implementing a simple optimization scheme, a composed, unique depth value per event is estimated, utilizing focal data from multiple resources. In the end and after validating magnitude’s (M) reliability, a brief spatiotemporal analysis of the provided catalog is performed, revealing its potential for further exploitation in large scale seismological surveys or other research studies of global interest.
SEISMIC HAZARD ASSESSMENT IN THE BROADER AEGEAN AREA USING TIME-INDEPENDENT SEISMICITY MODELS BASED ON SYNTHETIC EARTHQUAKE CATALOGS
Authors: Vamvakaris D.A. , Papazachos C.B. , Papaioannou Ch.A. , Scordilis E.M. , Karakaisis G.F.
Published: July 2017

In order to evaluate the seismic hazard for the broader Aegean area, a modified timeindependent seismicity model is used. A Monte-Carlo procedure has been employed to create synthetic earthquake catalogs with specific characteristics regarding their time, space and magnitude distributions. Moreover, particular geometrical characteristics, such as subducting and oblique seismic zones are also taken into account in the synthetic catalogs generation. A significantly revised earthquake catalog, all available fault plane solutions and information on the seismotectonics of the broader Aegean area were considered in order to propose a new updated model of seismic zones for this area. Seismicity parameters for the new seismic zones were calculated and the corresponding synthetic earthquake catalogs were generated using the proposed procedure. The distribution of the expected values for ground motion parameters (e.g. PGA, PGV) was estimated using synthetic catalogs for several sites of interest, by performing computations directly on all earthquakes of each catalog. Computations were performed for a dense grid of sites and seismic hazard estimates were determined both directly from the peak ground motion distribution, as well as from fitted extreme values Gumbel distribution. Ground motion parameters were also calculated using classic seismic hazard assessment algorithms (EqRISK), in order to evaluate the compatibility of the proposed method with conventional approaches.
HYDROTHERMAL ALTERATION ZONES DETECTION IN LIMNOS ISLAND, THROUGH THE APPLICATION OF REMOTE SENSING
Authors: Anifadi A. , Parcharidis Is. , Sykioti O.
Published: July 2017

In this study we use Landsat 8 OLI satellite imagery in order to identify and map alteration zones in Limnos island (N. Aegean, Greece). Pre-processing included sea and vegetation masking. In order to enhance spatial resolution, data fusion to 15m is performed. A lineament map is extracted from the panchromatic image that gives the general tectonic view of the island. The detection and mapping of alteration minerals is performed using specific band ratios and consequent composite images. The colour composite using bands 10, 11, 7 (RGB) show the spectral signature and general distribution of silica. Band ratios 6/7, 4/2, 6/5, reveal alteration zones containing iron oxides, clay alteration and ferrous minerals correspondingly. The aforementioned analysis has shown that hydrothermally alteration areas in Limnos are located in the west part of the island and at the Fakos Peninsula, Sardes, Roussopouli and Paradeisi hill. These areas are compared and validated with the reported field work. We conclude that hydrothermal alteration zones can indeed be detected and mapped using medium resolution satellite multispectral data. However, for the identification and mapping of specific types of rocks and minerals, a sensor with high spectral resolution is required.
TRANSFORMING GEOLOGICAL AND LANDISLIDE SUSCEPTIBILITY MAPPING DATA TO LINKED (OPEN) DATA FOR HAZARD MANAGEMENT
Authors: Atzemoglou A. , Kotzinos D. , Grinias El. , Spanou N. , Pappas Ch.
Published: July 2017

The frequent lack of information to populations exposed to landslides is a component of the social vulnerability and can strongly increase the risk on lives and infrastructures. Determining the extent of the landslide hazard requires identifying those areas which could be affected by a damaging landslide. The users need to integrate different landslide data in order to first understand and then possibly become resilient to any potential catastrophic event. More precisely, public and private organizations can choose between different land use options to minimize the risk on the already existing infrastructures or to reduce the hazard itself through mitigation measures. From the other hand, the land use planners can also take best decisions before planning new infrastructures in high risk landslides’ areas. Based on these data we have also implemented new tools, available every day and reusable by anyone interested, to identify land areas susceptible for landslides. The tools are based on cloud web services, especially for the management and presentation of these datasets in order to provide stakeholders with valuable information about past distribution of the landslides, type of bed rock, rainfall etc. in order to focus on land use policies and assess an impending landslide.
Recent advances in cancer surgery in older patients
Authors: Rostoft Siri , Audisio Riccardo A.
Published: July 2017

Age is the most important risk factor for the occurrence of cancer, and a declining mortality from heart disease and other non-cancer causes leaves an older population that is at high risk of developing cancer. Choosing the optimal treatment for older cancer patients may be a challenge. Firstly, older age and associated factors such as comorbidities, functional limitations, and cognitive impairment are risk factors for adverse effects of cancer treatment. Secondly, older patients are often excluded from clinical trials, and current clinical guidelines rarely address how to manage cancer in patients who have comorbidities or functional limitations. The importance of incorporating frailty assessment into the preoperative evaluation of older surgical patients has received increasing attention over the last 10 years. Furthermore, studies that include endpoints such as functional status, cognitive status, and quality of life beyond the standard endpoints, i.e. postoperative morbidity and mortality, are starting to emerge. This review looks at recent evidence regarding geriatric assessment and frailty in older surgical cancer patients and provides a summary of newer studies in colorectal, liver, pancreatic, and gynecological cancer and renal and central nervous system tumors.
Modern means of implementation of automated systems. Working with Google spreadsheets
Authors: Бильфельд  , Bilfyeld Nikolay , Володина  , Volodina Yuliya
Published: July 2017

The tutorial discusses techniques for working with Google spreadsheets and the basics of the language Java Script. In Google sheets with descriptions of all menu items, functions and features of the application. Every action is accompanied by explanations and illustrative graphic material. In the second part of the fundamentals of Java Script, describes the functions, properties and methods of the language, which are accompanied by code examples. This manual is issued as a core literature for independent preparation for lectures and practical works on discipline "Modern means of implementation of automated systems" and meets the GEF IN the masters of the direction "computer science".
Book Reviews
Authors: Shen Wenjing
Published: July 2017

In Book Reviews, we review an extensive and diverse range of books. They cover theory and applications in operations research, statistics, management science, econometrics, mathematics, computers, and information systems. In addition, we include books in other fields that emphasize technical applications. The editor will be pleased to receive an email from those willing to review a book, with an indication of specific areas of interest. If you are aware of a specific book that you would like to review, or that you think should be reviewed, please contact the editor. The following books are reviewed in this issue of Interfaces, 47(4), July–August: Cross-Functional Inventory Research, Srinagesh Gavirneni, ed.; The Undoing Project: A Friendship That Changed Our Minds, Michael Lewis.
A Unified Approach to Time Consistency of Dynamic Risk Measures and Dynamic Performance Measures in Discrete Time
Authors: Bielecki Tomasz R. , Cialenco Igor , Pitera Marcin
Published: July 2017

In this paper, we provide a flexible framework allowing for a unified study of time consistency of risk measures and performance measures (also known as acceptability indices). The proposed framework not only integrates existing forms of time consistency, but also provides a comprehensive toolbox for analysis and synthesis of the concept of time consistency in decision making. In particular, it allows for in-depth comparative analysis of (most of) the existing types of time consistency—a feat that has not been possible before and, which is done in the companion paper by the authors. In our approach, the time consistency is studied for a large class of maps that are postulated to satisfy only two properties—monotonicity and locality. We call these maps LM-measures. The time consistency is defined in terms of an update rule. The form of the update rule introduced here is novel, and is perfectly suited for developing the unifying framework that is worked out in this paper. As an illustration of the applicability of our approach, we show how to recover almost all concepts of weak time consistency by means of constructing appropriate update rules.
The Influence of Hierarchy on Idea Generation and Selection in the Innovation Process
Authors: Keum Dongil D. , See Kelly E.
Published: July 2017

The link between organizational structure and innovation has been a longstanding interest of organizational scholars, yet the exact nature of the relationship has not been clearly established. Drawing on the behavioral theory of the firm, we take a process view and examine how hierarchy of authority—a fundamental element of organizational structure reflecting degree of managerial oversight—differentially influences behavior and performance in the idea generation versus idea selection phases of the innovation process. Using a multimethod approach that includes a field study and a lab experiment, we find that hierarchy of authority is detrimental to the idea generation phase of innovation, but that hierarchy can be beneficial during the screening or selection phase of innovation. We also identify a behavioral mechanism underlying the effect of hierarchy of authority on selection performance and propose that selection is a critical organizational capability that can be strategically developed and managed through organizational design. Our investigation helps clarify the theoretical relationship between structure and innovation performance and demonstrates the behavioral and economic consequences of organizational design choice.

The online appendix is available at https://doi.org/10.1287/orsc.2017.1142 .
Dementia: The path to a cure
Authors: Frankova Helena
Published: July 2017

When it comes to drug development, scientists ‘do the maths’ and identify how and where drugs can be targeted, leading to treatments becoming available. Why is this process slow when it comes to dementia? Helena Frankova reviews some of the stumbling blocks
Maintaining practice profit and cash flow
Authors: Dempsey Mark
Published: July 2017

Mark Dempsey provides some top tips for establishing systems to protect the day-to-day cash flow of your practice
Confidentiality and duty of care
Authors: Gauge-Klein Teri
Published: July 2017

Will doctors in the field of Huntington's disease have to start disclosing details of their patients diagnosis to family members, even when the patient refuses? Teri Gauge-Klein looks in detail at a recent case at the Court of Appeal
Why are we living longer?
Authors: Moffat Polly
Published: July 2017

A new report addresses questions about why the general population is living longer and how much is spent in good health. What do the results tell us?
PRODUÇÃO DE CANA-DE-AÇÚCAR IRRIGADA E FERTIRRIGADA COM EFLUENTE URBANO DE GOIÂNIA-GO
Authors: Mussi Rodolfo Fernandes , ALVES JR. JOSÉ , Evangelista Adão Wagner Pego , Casaroli Derblai , Flores Rilner Alves
Published: July 2017

Os efluentes domésticos contêm teores de macro e micronutrientes suficientes para atender parcialmente ou totalmente as plantas. A sua utilização na agricultura é uma alternativa ecológica que pode minimizar os impactos gerados pela redução dos dejetos nos rios, além de proporcionar menor custo de produção da cultura pela redução de gastos com insumos, devido a presença de nutrientes contido nos efluentes. O objetivo do trabalho foi simular o aproveitamento do efluente doméstico gerado na cidade de Goiânia para o cultivo da cultura da cana-de-açúcar e produção do etanol e geração de energia elétrica com a queima da biomassa. A quantidade de efluente gerado é capaz de suprir a necessidade hídrica de uma área aproximada de 5 mil ha de canavial com irrigação plena, e necessidade nutricional, contando com o retorno da vinhaça em fertirrigação. A quantidade de etanol produzida pode ser capaz de manter o consumo de todos os motores utilizados na irrigação. Além da produção de biomassa, que é capaz de produzir um excedente de energia suficiente para atender o consumo de um bombeamento de cerca de 30 ha irrigados. A reutilização do efluente na agricultura por meio de irrigação e fertirrigação é uma forma de tratamento eficaz, evitando ser lançado nos rios, reduzindo o impacto ambiental.
Comparisons of external fixator combined with limited internal fixation and open reduction and internal fixation for Sanders type 2 calcaneal fractures
Authors: Pan M. , Chai L. , Xue F. , Ding L. , Tang G. , Lv B.
Published: July 2017

Objectives

The aim of this study was to compare the biomechanical stability and clinical outcome of external fixator combined with limited internal fixation (EFLIF) and open reduction and internal fixation (ORIF) in treating Sanders type 2 calcaneal fractures.

Methods

Two types of fixation systems were selected for finite element analysis and a dual cohort study. Two fixation systems were simulated to fix the fracture in a finite element model. The relative displacement and stress distribution were analysed and compared. A total of 71 consecutive patients with closed Sanders type 2 calcaneal fractures were enrolled and divided into two groups according to the treatment to which they chose: the EFLIF group and the ORIF group. The radiological and clinical outcomes were evaluated and compared.

Results

The relative displacement of the EFLIF was less than that of the plate (0.1363 mm to 0.1808 mm). The highest von Mises stress value on the plate was 33% higher than that on the EFLIF. A normal restoration of the Böhler angle was achieved in both groups. No significant difference was found in the clinical outcome on the American Orthopedic Foot and Ankle Society Ankle Hindfoot Scale, or on the Visual Analogue Scale between the two groups (p > 0.05). Wound complications were more common in those who were treated with ORIF (p = 0.028).

Conclusions

Both EFLIF and ORIF systems were tested to 160 N without failure, showing the new construct to be mechanically safe to use. Both EFLIF and ORIF could be effective in treating Sanders type 2 calcaneal fractures. The EFLIF may be superior to ORIF in achieving biomechanical stability and less blood loss, shorter surgical time and hospital stay, and fewer wound complications. Cite this article: M. Pan, L. Chai, F. Xue, L. Ding, G. Tang, B. Lv. Comparisons of external fixator combined with limited internal fixation and open reduction and internal fixation for Sanders type 2 calcaneal fractures: Finite element analysis and clinical outcome. Bone Joint Res 2017;6:433–438. DOI: 10.1302/2046-3758.67.2000640.