bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical case of acute kidney injury in a patient with COVID-19
Authors:   Kazan State Medical University, NURULLINA G. I. , KHALFINA T. N. ,   Kazan State Medical University, ISLAMOVA G. M. ,   Republican Clinical Hospital of the MH of RT, SAGITOVA A. S. ,   Kazan State Medical University, KRASNOVA L. A. ,   Samara State Medical University
Published: May 2022

The purpose — to present a clinical case of acute kidney injury after a new coronavirus infection SARS-Cov-2 against the background of existing long-term renal disease. Material and methods. Patient B., male, 73 years old, was transferred to the Nephrology Department of the Republican Clinical Hospital due to the increase in azotemia and a need for acute hemodialysis. Results. As is known from the anamnesis, the patient was treated in a COVID hospital since October 2020. During hospitalization, creatinine (144.7 mmol/L) and urea (9.4 mmol/L) were slightly increased, but given a long renal history, the data obtained were interpreted in favor of the presence of stage 3B CKD. Further, the patient was discharged in a satisfactory condition due to an improvement and a double negative result of the coronavirus test. Then the patient’s condition worsened, which led to a second hospitalization in the COVID hospital. Diagnostics revealed a sharp increase in creatinine (944 mmol/L) and urea (38.5 mmol/L). These changes were regarded as the development of acute renal injury. For further treatment, the patient was transferred to the Nephrology Department of the Republican Clinical Hospital. Timely treatment by acute hemodialysis allowed achieving positive dynamics and stabilization of kidney functions. Conclusion. The development of a new coronavirus infection does not exclude primary kidney damage, as well as acute damage against the background of an existing disease.
Early diagnosis of chronic kidney disease in children: problems and solutions
Authors:   Samara State Medical University, PECHKUROV D. V. , POLKANOVA V. A. ,   Samara State Medical University, VORONINA E. N. ,   Samara State Medical University, PORETSKOVA G. YU. ,   Samara State Medical University
Published: May 2022

The urgency of the problem of searching for sensitive and specific biomarkers of nephron damage in various pathological conditions is due to the increasing prevalence of chronic kidney disease in children. Currently, chronic kidney disease is determined by a decrease in the glomerular filtration rate, however, this indicator is quite variable, and its fluctuations depend on many factors, such as age, features of the disease, nutrition, and physical activity. The article presents an overview of research on the problem of early diagnosis of chronic kidney disease in children. The advantages and disadvantages of early biomarkers of kidney damage are described, which include NGAL, KIM-1, VEGF, TIMP-1, Type IV collagen, serum creatinine, cystatin C. The conducted studies demonstrate the high diagnostic value of cystatin C in the initial stages of chronic kidney disease.
Modern methods of body composition analysis
Authors:   State Scientific Center Federal Medical Biophysical Center named after A.I. Burnazyan, SAMOYLOV A. S. , ZHOLINSKIY A. V. ,   Federal Scientific and Clinical Center for Sports Medicine and Rehabilitation of the FMBA of Russia, RYLOVA N. V. ,   State Scientific Center Federal Medical Biophysical Center named after A.I. Burnazyan, VELICHKO M. N. ,   State Scientific Center Federal Medical Biophysical Center named after A.I. Burnazyan, BOLSHAKOV I. V. ,   State Scientific Center Federal Medical Biophysical Center named after A.I. Burnazyan, BODROV A. V. ,   State Scientific Center Federal Medical Biophysical Center named after A.I. Burnazyan, SIMONOV R. A. ,   State Scientific Center Federal Medical Biophysical Center named after A.I. Burnazyan, CHIZHIKOV P. D. ,   State Scientific Center Federal Medical Biophysical Center named after A.I. Burnazyan
Published: May 2022

The article provides an overview of the Russian and foreign literature on modern methods for analyzing body composition. Much attention is paid to the description of such common methods as the measurement of anthropometric parameters and bioimpedance analysis. Despite low accuracy, anthropometry is still one of the most popular methods for an approximate assessment of nutritional status. We also discuss in detail the most commonly used laboratory methods, such as dual-energy X-ray absorptiometry, computed tomography and magnetic resonance imaging, which can provide accurate and comprehensive information about the human body composition. The need for body composition analysis exists in such areas of clinical medicine as dietetics, nephrology, combustiology, surgery, cardiology, anesthesiology and resuscitation, etc. It was concluded that, depending on the goals and objectives in a particular clinical situation, various research methods and their combinations can be used.
Genetic engineering therapy of severe asthma in children: experience of application
Authors:   Orenburg State Medical University of the Ministry of Health of Russia, ALEMANOVA G. D. , POPOVA L. YU. ,   Orenburg State Medical University of the Ministry of Health of Russia, ZLODEEVA E. A. ,   Orenburg State Medical University of the Ministry of Health of Russia, VOLYANIK O. V. ,   Orenburg State Medical University of the Ministry of Health of Russia, KASHAEVA R. R. ,   Orenburg State Medical University of the Ministry of Health of Russia
Published: May 2022

This article presents the results of anti-IgE-therapy in children with severe persistent uncontrolled atopic bronchial asthma. The clinical course of the disease during 3 years of follow-up was analyzed. The effectiveness of IgE-therapy was evaluated by the frequency of hospitalizations, asthma control, and changes in baseline therapy. Treatment with Omalizumab resulted in decreased frequency of acute states, normalized external respiration function, reduced severity of co-morbid pathology in the form of allergic rhinitis and atopic dermatitis.
Сorrelation between the number and aggregation capacity of platelets and the process of lipid peroxidation in patients with chronic hepatitis С
Authors:   Kazan State Medical University, GALEEVA N. V. , VALEEVA I. KH. ,   Kazan State Medical University, FAZYLOVA YU. V. ,   Kazan State Medical University
Published: May 2022

The purpose — to determine the role of the relationship between the number and aggregation capacity of platelets (Tr) with the process of lipid peroxidation (POL) in the natural course of chronic hepatitis C (HCV). Material and methods. 332 patients with HCV were observed, divided into three groups according to the phases of disseminated intravascular coagulation and the number of Tr: the first group — the hypercoagulation phase (Tr > 330 x 109/l, n = 22); the second — the transition phase (Tr from 330 to 200 x 109/L, n = 132); the third — hypocoagulation (Tr < 200 x 109/L, n = 178). The vascular-platelet link of hemostasis was evaluated by the number and degree of maximum amplitude (MA) of spontaneous Tr aggregation. The POL process was studied by medium-weight molecules (MSM), malonic dialdehyde (MDA), and enzymes — superoxide dismutase (SOD), reduced (VG) and oxidized (OG) glutathione. Results. The decrease in the number of Trs against the background of prolonged infection with the hepatitis C virus was accompanied by a decrease in the antioxidant potential, an increase in the intensity of lipoperoxidation and an increase in the ability of Tr to aggregate, especially pronounced in the phase of hypocoagulation. Correlations were revealed: the numbers Tr showed inverse correlation with the levels of SOD, MSM, MDA, OG and direct correlation with VG; MA of spontaneous aggregation Tr showed direct correlation with MSM, MDA, SOD, OG and inverse correlation with VG. Conclusions. Changes in the number and aggregation ability of Tr, the level of POL products in the course of the natural course of HCV, in parallel with the ALT enzyme, reflect the activity of the infectious process. The number and MA of spontaneous Tr aggregation in patients with natural HCV with exacerbation of the disease correlate with a reduced antioxidant potential and increased intensity of lipoperoxidation. The natural course of HCV is characterized by a multidirectional change in the AOS enzymes – an increase in the SOD level and a decrease in the amount of reduced glutathione with a simultaneous increase in the oxidized one.
Approaches to antianginal therapy selection in patients with diabetes mellitus type 2
Authors:   M. Gorky Donetsk National Medical University, MYKHAILICHENKO I. S. , BAGRIY V. A. ,   Central City Clinical Hospital No. 1, ANDRUSYAK A. YU. ,   M. Gorky Donetsk National Medical University, GOLODNIKOV I. A. ,   M. Gorky Donetsk National Medical University
Published: May 2022

The purpose — to study the efficacy and tolerability of different classes of antianginal drugs in patients with chronic coronary artery disease with DM2 having stable angina pectoris syndrome. Material and methods. 104 patients (m/w 59/45, average age — 64.7 (11.1) years) with DM2 and with stable angina pectoris were under observation. All patients received adequate hypoglycemic, vaso- and cardioprotective therapy. All patients were prescribed antianginal agents in various combinations: β-AB — in 32 (30.8%) cases, calcium channel blockers — in 30 (28.8%), ivabradine — in 29 (27.9%), ranolazine — in 25 (24.0%), nitrates — in 22 (21.2%), trimetazidine — in 38 (36.5%), and meldonium — in 34 (32.7%) cases. Before the start of follow-up and after 16 weeks of treatment the angina pectoris class and standard clinical and biochemical parameters were evaluated, echocardiographic examination, Holter monitoring of an electrocardiogram, a test with reactive hyperemia were performed. Results. The treatment provided a rapid, distinct and stable antianginal effect. Thus, the average levels of angina pectoris decreased from 2.37 (0.4) to 1.19 (0.1), p < 0.05. A significant decrease in clinical manifestations of angina pectoris was achieved after 2 weeks from the start of treatment in 72 (69.2%), and after 4 weeks — in 93 (89.4%) people. A reliable relationship between the higher antianginal efficacy of treatment and some clinical and laboratory features of patients was revealed. Conclusions. In individuals with stable angina and DM2, adequate use of antianginal drugs provides a rapid and stable decrease in the severity of angina.
Body composition in children with inflammatory bowel disease
Authors:   Kazan State Medical University, KAMALOVA A. A. , SAFINA E. R. ,   Kazan State Medical University, GAIFUTDINOVA A. R. ,   Kazan State Medical University
Published: May 2022

Underweight and growth retardation are the main extraintestinal manifestations of inflammatory bowel disease (IBD) in children and are especially common among patients with Crohn’s disease (CD). Anthropometry and laboratory parameters cannot always reveal hidden violations of the nutritional status of patients. In this regard, the method of bioelectrical impedance is being actively introduced into clinical practice to assess the component composition of the body. There are few publications in the literature, according to which children with IBD have a disturbed body component composition; mainly it is the indicators of fat and muscle mass that change. However, a number of questions remain regarding the effect of therapy, duration, stage and activity of the disease on the nutritional status of children with IBD, including body composition, which require further study. The purpose was to evaluate the body composition in children with inflammatory bowel diseases. Material and methods. We observed 63 children aged 5 to 18 years with IBD: with CD — 23 children, with ulcerative colitis (UC) — 40 children. Body composition was determined using bioelectrical impedance analysis. Results. Body composition differed in children with IBD depending on the disease. Children with CD were more likely to be fat deficient than children with UC (p = 0.014), and children with UC were more likely to have excess fat mass (p = 0.038). The content of fat and active cell mass was lower in CD compared with UC. Lower rates of fat mass were observed both at the onset and during remission of CD. A decrease in the phase angle was observed more often in children with CD during the disease exacerbation (p = 0.029). A third of children with UC with normal physical development have deviations in the indicators of the body component composition according to the results of bioelectrical impedance analysis. Conclusions. Further prospective studies of body composition and phase angle in children with IBD are needed to analyze the effect of therapy, duration and period of the disease.
Emergency prevention of tick-borne encephalitis in children: retrospective analysis and clinical cases
Authors:   Children’s Research and Clinical Center for Infectious Diseases of the Federal Medical and Biological Agency of Russia, SKRIPCHENKO N. V. , IVANOVA G. P. ,   RZhD-Meditsina Clinical Hospital, PULMAN N. F. ,   Children’s Research and Clinical Center for Infectious Diseases of the Federal Medical and Biological Agency of Russia, VILNITS A. A. ,   Children’s Research and Clinical Center for Infectious Diseases of the Federal Medical and Biological Agency of Russia, SKRIPCHENKO E. Y. ,   Children’s Research and Clinical Center for Infectious Diseases of the Federal Medical and Biological Agency of Russia
Published: May 2022

The purpose — to conduct a retrospective analysis of the effectiveness of anti-tick borne immunoglobulin (IgG) and technologically processed antibodies to interferon gamma (ТOАIG) (аnaferon for children) for the emergency prevention of tick-borne encephalitis (TBE) in children. Material and methods. The analysis of medical documentation of patients with TBE who received various emergency prevention: anti-tick-borne IgG in the dose of 0.1 ml/kg i/m once (n = 626) or ТОАIG during 21 days (n = 354) or anti-tick-borne IgG together with ТОАIG (n = 56). The comparison group consisted of 351 patients with TBE who were admitted to the clinic and had not received any prevention. In groups of children who received various emergency prevention regimens, blood was examined by PCR method for the TBE virus at 1, 2 and 6 months after a tick bite. Results. Both the children affected by ticks and among those who got ill were predominantly 7 to 17 years old, 76.1 and 93%, respectively. Among the patients with TBE, 77.6% had not received any prevention, and 22.4% had different emergency prevention tactics. When prescribing anti-tick-borne IgG to children affected by ticks infected with the TBE virus, infection developed in 27.3% of cases (n = 93); when taking ТОАIG — in 1.7% (n = 3), and when using anti-tick-borne IgG and ТОАIG together — in 8.9% of cases (n = 5). The implementation of ТОАIG resulted in only 3 cases of asymptomatic acute (inapparent) infection identified by PCR results. After the introduction of anti-tick-borne IgG to 93 children, a half of them developed manifest forms of TBE, including 16.1% — meningeal forms and 5.4% — forms with focal neurological symptoms and brain edema. When anti-tick-borne IgG was used together with ТОАIG, fever form was observed in 40% (n = 2) and inapparant form in 60% (n = 3) of cases. The article presents 4 cases of severe focal cerebrospinal forms of tick-borne encephalitis associated with the ineffectiveness of the anti-tick-borne IgG for preventive purposes. Conclusions. The maximum effectiveness (98.3%) for emergency prevention was shown by an immunomodulator ТОАIG (anaferon for children), while 21.5% of children (20 cases out of 93) developed clinical forms of tick-borne neuroinfection with CNS damage syndromes and the number of non-patients was 72.7%.
PENINGKATAN EFISIENSI PADA SISTEM PLTMH DENGAN CARA TURBIN HIBRID CROSSFLOW DAN PROPELLER HEAD 5 M
Authors: Sukusno Paulus
Published: May 2022

Sistem PLTMH dengan turbin hibrid dapat menghasilkan efisiensi lebih baik dari yang hanya menggunakan turbin tuggal (turbin propeler atau turbin crossflow), bila debid air yang digunakan relatif sama. Sistem PLTMH dengan turbin hibrid tidak selalu dapat menghasilkan daya listrik lebih baik dari yang hanya menggunakan turbin tuggal.
KAJIAN PENGARUH JENIS MATERIAL TERHADAP KUALITAS UKURAN PADA PROSES PENEKUKAN PELAT DENGAN METODA ANOVA
Authors: Rachman Rosidi , Almahdi Almahdi , Yuhas Darius
Published: May 2022

Abstract

In previous research, it has been proven that the measurement technique, setting and use of quality measuring instruments can increase the quality of measurements during the bending process of steel plates (ST.37). However, this research has not examined the types of materials other than steel, even though other materials apart from ST.37, for example aluminum plates, brass plates and steel plates are widely used, especially in the manufacturing industry.. Therefore, the aim of this research is to analyze the effect of the type of material on the quality of the measurement in the bending process. This study uses an experimental method, combined with a theory that supports the discussion of the problem. The materials used are 3 different types of material plates (aluminum plate, brass plate and steel plate). The parameters observed include the measurement technique, setting and use of measuring instruments. Each material received 10 repetitions of the measurements. These three parameters were analyzed using ANOVA statistics, in order to determine the quality of the measurement of each material and the most dominant factors affecting the quality of the measurements.

Keywords: Plates, measurements, bending processes, and statistics.
LIMBAH BUAH PISANG SEBAGAI BIOAKTIVATOR ALTERNATIF PADA PENGOMPOSAN SAMPAH ORGANIK
Authors: Kartika Wahyu
Published: May 2022

Abstrak
Limbah buah pisang (LBP) dapat menurunkan estetika lingkungan baik dari segi keindahan maupun bau yang ditimbulkan. Salah satu solusi mengatasi hal tersebut dengan memanfaatkan LBP menjadi bioaktivator (BA) alami untuk membantu pengomposan. Tujuan dari penelitian ini adalah mengetahui waktu pengomposan dan kualitas kompos. Penelitian dilaksanakan dua tahap: pembuatan BA; dan proses pengomposan. Pembuatan BA dilakukan selama 14 hari dengan 2 perlakuan penambahan gula pasir (GP): 200 gram GP (notasi S1); dan 250 gram GP (notasi S2) serta satu kali ulangan, kemudian diaduk setiap 3 hari sekali sampai larutan menjadi coklat muda bening dan pada permukaannya membentuk layer nata tipis. S1 memenuhi kriteria sebagai BA dengan waktu pengomposan 30 hari, dengan pengecekan suhu dan penimbangan berat kompos setiap 3 hari sekali. Penyusutan berat kompos menjadi 56%, berwarna coklat kehitaman, suhu 320C, bau seperti tanah, kadar P2O5, kadar K2O dan kadar air sesuai SNI 19-7030-2004, sedangkan pH, N, C-organik, rasio C/N tidak sesuai SNI 19-7030-2004.
Kata kunci: Limbah buah pisang, Bioaktivator alami, Pengomposan
PENGARUH PERUBAHAN TEMPERATUR KABIN TERHADAP KINERJA PADA SISTEM REFRIGERASI FREEZE DRYING
Authors: Wardika Wardika , Setiawan Aa , Fitriyani Tri Wulan
Published: May 2022

Tujuan penelitian ini adalah untuk mengetahui kinerja dari mesin freeze drying dengan variasi perubahan temperatur kabin. Metode yang digunakan dalam penelitian ini adalah dengan membandingkan langsung perubahan setpoint pada temperatur kabin -10oC, -15oC dan -20oC terhadap kinerja pada sistem refrigerasi mesin freeze drying dimana dimensi kabin 40cmx40cmx40cm, dengan beban produk irisan buah mangga sebesar 3 kg. Berdasarkan hasil pengolahan data yang dilakukan pada freeze drying didapat kinerja sistem pada COP aktual temperatur kabin -10oC sebesar 2,7, temperatur kabin -15oC sebesar 2,8 dan temperatur kabin -20oC sebesar 2,7. Efisiensi sistem pengeringan beku dengan variasi temperatur masing-masing -10oC, -15oC, dan -20oC sebesar 63%, 62,7% dan 63,1%.
 
Kata kunci : freeze drying, temperatur, Kinerja, Kualitas produk.
APPLICATION OF CLUSTER ANALYSIS IN THE TOURISM INDUSTRY OF THE EUROPEAN SPACE
Authors:   Dmytro Motornyi Tavria State Agrotechnological University, Trusova Natalia , Krasnoded Tetiana ,   Dmytro Motornyi Tavria State Agrotechnological University
Published: May 2022

It is determined that the cluster approach is a necessary tool for creating the spatial development of the world's tourist regions, and the focus on the formation of competitive advantages of tourist clusters will lead to the production of creative innovative tourism products. The study examines the competitiveness index according to a set of indicators, which are grouped into four subindexes – environmental friendliness, public policy and the creation of favorable conditions, infrastructure, natural and cultural resources. A cluster analysis of the factors that create the regional potential of clusters in the tourism industry of the European space has been carried out. The features of the competitive environment in the tourism services market and its impact on the competitiveness of economic entities of the tourism industry are considered. The number and composition of tourism clusters in the EU member states is demonstrated. With the help of cluster analysis and audit, more competitive tourist clusters of the European space have been identified. A correlation analysis was carried out between the general competitiveness index of the EU member states in the field of travel and tourism and its subindexes. The results of this analysis confirm the existence of a direct relationship between these components. In order to characterize tourist clusters and determine the degree of development of their tourism potential, the process of combining clusters by the Ward method and the K-means method was used, which made it possible to determine various levels of competitiveness of the travel and tourism sector. The forecasting tool is applied by the method of extrapolation of market trends and indicators. The forecast efficiency of the development of the regional potential of tourist clusters is calculated using the growth rates of the final product. As the main indicators of forecasting, such indicators as the growth rate of national income, the rate of dynamics of visits to tourist sites and recreation in the country, the parameter of the degree of labor intensity, labor productivity growth, the parameter of the degree of capital intensity, the growth of capital return are selected.
MARKETING BUSINESS COMPETITIVENESS MANAGEMENT SYSTEM: ENTREPRENEURSHIP STRUCTURES DESIGN, IMPACT OF MODERN MACROECONOMIC AND GLOBAL PROBLEMS
Authors:   V.N. Karazin Kharkiv National University, Kim Oleksii , Shumilo Olga ,   V.N. Karazin Kharkiv National University, Yevtushenko Viktoriia ,   V.N. Karazin Kharkiv National University
Published: May 2022

The research focuses on the important interdisciplinary issue of the agile marketing management systems implementations under the design stage of the entrepreneurship structures. Today the entrepreneurship ecosystem is under massive impact of global and macroeconomic challenges, actualized by different instances of global problems and behavioral factors. The competitiveness of the entrepreneurship structures depends upon the agile marketing systems of market data processing. The task is to show the great role of global changes and local response of the target audience behavior. During the process of the decision-making, the entrepreneurship structures are analyzing the statistical data to ensure that the decision is correct, or wrong. There are different sources of marketing data to manage competitiveness in international business environment. More available and accessible data is the statistic – obtained during the sales, processing, manufacturing, etc. also, if the market is new for the business, we can analyze macroeconomic, branch or local statistics to create the strategy or approve the decisions for the entrepreneurship design. Another possibility, which does not replace but complements the existing data sources, is the behavioral data from the services like Google analytics, Google trends, Google ads, other behavioral data sources, available online. The Agile-marketing concept let the marketing manager use combined data sources in the decision-making process. Agility in the decision-making and data processing is the key to the competitiveness building during the entrepreneur structures design process. The macroeconomic and global challenges, provoked by the global problems of today are important – among them, ecology problems, education problem, hunger, global partnership building, etc. These problems are important for the social responsible marketing systems, gaining popularity all over the world. Also, competitiveness depends upon the agility in the marketingmix of the entrepreneur structures – the speed of response and decision-making in the changing or undefined environment. During the market research, the results may show that the strategy is correct, but some elements of marketing-mix are misused – in this circumstances the marketing-mix must be changed immediately. This is the agile marketing management systems main task in the changing market environment.
COMPLEX ASSESSMENT OF THE LEVEL OF FINANCIAL AND ECONOMIC SECURITY OF THE ENTERPRISE
Authors:   Lviv University of Trade and Economics, Kopylyuk Oksana , Muzychka Oleksandra ,   Lviv University of Trade and Economics, Rutar Roman ,   Lviv University of Trade and Economics
Published: May 2022

The essence of the category «financial and economic security of the enterprise» as a universal and comprehensive definition, based on the system of identification, assessment, minimization of potential and real risks, threats and dangers, maximizes performance, business value, protects the interests of all participants in the production and economic process . The level of financial and economic security of the enterprise is assessed in quantitative and qualitative terms in a dynamic dimension. The author's approach to the method of assessing the level of financial and economic security of the enterprise based on the indicator approach, which allows to differentiate the following levels of security: high, satisfactory, unsatisfactory, critical. The algorithm of indicator assessment of financial and economic security determines the weights for the main subgroups, taking into account their importance and the level of impact (positive, negative) on financial and economic security. The high level of financial and economic security of the enterprise provides resistance to threats and dangers, the ability to selffinance, implement current and strategic plans. A satisfactory level of financial and economic security of the enterprise indicates that the problems are potential, real risks and threats do not affect the ability of the enterprise to pay its obligations. Unsatisfactory level of financial and economic security of the enterprise shows the existing real crisis phenomena and threats, the level of solvency of the enterprise is low, requires reactive management to overcome threats and dangers. The critical level of financial and economic security of the enterprise confirms the signs of insolvency, inability to repay obligations, threats and dangers are real, can lead to bankruptcy or reorganization. As partial components, security indicators are proposed: property status, liquidity, financial stability, business activity, profitability. The practical implementation of this technique was carried out using the actual data of PJSC «Carlsberg Ukraine» for 2016–2020. and identified a high level of financial and economic security of the entity. It is noted that the company has reserves for economic growth, increase of own capital and potential, its activity is balanced, financial stability is high.
TRANSFORMATION OF THE CONSULTING SERVICES MODEL
Authors:   National Transport University, Levishchenko Olena , Komchatnykh Olena ,   National Transport University, Amelina Nataliia ,   National Transport University
Published: May 2022

The article considers the periodization of the development of the global consulting market in terms of industrial revolutions, institutional and social transformations from consulting 0.0 – at its inception to consulting 4.0, which was due to intensive changes in the technological development of the world, the spread of innovation, as a consequence of changing technology growth strategies in all areas of the economy. The purpose of the study is to analyze the historical paradigm of consulting development and study the impact of digital technology on consulting services. The consulting industry began to enter the international market in the early 60's, bringing its management models and expertise to the transformation of European organizations. Over the next thirty years, the consulting industry found itself in a phase of rapid growth in Western markets, far outpacing the growth of the global economy over the same time period. At the core of the industry are six main areas – management consulting, strategic consulting, operational consulting, human resources consulting, financial consulting and technology consulting, combining services and offerings in different functional areas. The transformation of the consulting services model has undergone several transformations: classic model – combined model – digital model. The classic business model of consulting consists of four elements: information, expertise, insight, implementation. To the combined model are added digital technologies, which do not simply complement the work of the consultant, but are directly involved in the consulting process. The digital model of consulting services will be based on the use of all available digital technologies under the control of artificial intelligence. The Covid-19 pandemic has a huge impact on the economy as a whole, which of course has a significant impact on changes in the consulting market as well. Changes in the consulting market are occurring in three ways: by geographic region, by industry, and by the structure of consulting itself. Management decisions related to the pandemic have led to two unexpected results: companies have been forced to adapt their traditional methods to survive the crisis (remote work); companies have accelerated the process of technology adoption, accelerating the transition to an on-demand workforce model.
THE APPLICATION OF MODERN MARKETING TOOLS AS A FOUNDATION TO INCREASE THE MANAGEMENT EFFICIENCY OF THE ORGANIZATIONS
Authors:   Zhytomyr Polytechnic State University, Pashchenko Olha , Vyhovskyi Volodymyr ,   Zhytomyr Polytechnic State University, Zavalii Tetyana ,   Zhytomyr Polytechnic State University
Published: May 2022

The article is devoted to the study of the impact of the application marketing tools for the effectiveness of management of the organization as a whole. The peculiarities of using the sensory marketing as important marketing tool in modern business conditions have been studied. It is also determined that the main purpose of sensory marketing (neuromarketing) is to search the answers to the question “why consumers prefer one or another product”, in order to develop a methodology to encourage consumers to buy as on conscious, but also on an unconscious level. The own approach to the definition of the specified concept is offered: Neuromarketing is a modern innovative marketing tool that uses the researches on each aspect of perception: hearing, taste, smell, vision and is aimed at forming a cognitive image and a stable imaginary association with a particular product or company in the subconscious of the buyer. The advantages of using sensory marketing by the organizations are determined (the ability to identify implicit incentives for consumers to make purchases, that is, unconscious stimuli; creating a clear association of color, aroma, design, sound with a certain brand, product, organization; detection of the elements of marketing communications that have a motivating effect on the consumer; establishing a relationship between advertising and emotional impact on consumers) and outlines its impact on efficiency and effectiveness management. A model of the relationship between the application of marketing tools and the effectiveness of enterprise management has been developed. It is also determined that the whole process of organization management, i.e. management, is accompanied by the use of tools, methods and methodologies of marketing, which is associated with the fierce competition in the market and demanding consumers, the rapid variability of their needs and preferences. It is suggested to take into account the following component as marketing potential when forming a system of measuring instruments of enterprise development. It is determined that the indicator of development of marketing potential is the level of satisfaction and loyalty of the customers (clients) of the enterprise. The indicators corresponding to the indicator of marketing potential are outlined, in particular: a share of the enterprise on the market, a coefficient of the ratio of sales costs and net income from the realization of the production, an index of consumer satisfaction with the company's products.
ADAPTATION POTENTIAL AS THE BASIS OF FORMATION OF ADAPTIVE-ORIENTED MANAGEMENT SYSTEM OF ECONOMIC SECURITY OF THE ENTERPRISE
Authors:   King Daniel University, Polischuk Olesia
Published: May 2022

The survival, as well as the development, of Ukrainian enterprises largely depends on the ability to detect changes in the external environment and internal economic processes in a timely manner with the subsequent implementation of adaptation measures. The need for such steps is due to the fact that such changes may provoke threats that adversely affect the level of economic security of a particular enterprise. The formation of adaptive-oriented management system of economic security of the enterprise allows to identify such facts and apply appropriate protective measures, including the adaptation of both managed and control subsystems. To ensure the effectiveness of the actions of security actors, it is necessary to form and develop adaptation capacity. The purpose of the article is to characterize the essence of the concepts of "enterprise potential" and "adaptation potential" as a basis for determining the essence of adaptation potential as a component of adaptive-oriented management system of economic security of the enterprise. To outline the theoretical foundations of the formation of adaptation potential, the following methods were used: induction and deduction, comparison and systematization – in the study of the essential characteristics of the terms "enterprise potential" and "adaptation potential"; synthesis and analysis – to characterize the main approaches in the interpretation of the concept of "enterprise potential"; morphological analysis – to substantiate the parameters of adaptation potential in accordance with the types of adaptation; graphic – for visual presentation of theoretical and methodological material; abstract-logical – for theoretical generalizations and conclusions of the study. Based on the generalization of scientific work on the interpretation of the concepts of "enterprise potential" and "adaptation potential" formed his own approach, which differs in determining the place of adaptation potential in the adaptive-oriented management system of economic security. It is proposed to understand the adaptation potential, based on aspects of security activities, all available resources and opportunities that can be used to implement measures to adapt to the impact of internal and external threats arising from changing operating conditions, in accordance with the enterprise development strategy. improvement of management and control subsystems within the economic security management system as a basis for maintaining sustainability and ensuring development. The parameters of formation of adaptation potential ("maximum" and "minimum") according to the type of adaptation, which corresponds to the security policy and is consistent with the development strategy of the enterprise, are substantiated.
RISK MANAGEMENT IN THE ENTERPRISE MANAGEMENT SYSTEM
Authors:   Zhytomyr Polytechnic State University, Tkachuk Hanna , Vyhovskyj Volodymyr ,   Zhytomyr Polytechnic State University, Renchkovskaya Victoria ,   Zhytomyr Polytechnic State University
Published: May 2022

The article considers the essence of the enterprise management system and identifies the main elements of this system, which include: enterprise strategy, personnel, business processes, standardization, controlling and risks. It is established that the control system has a control and managed system, describes the priority areas of management. It is proved that the modern business environment is characterized by risk trends caused by various factors, among which should be noted: legal, administrative and tax risks, inflation and quarantine restrictions caused by the consequences of COVID-19. This is the reason for the need to introduce risk management as a separate element in the overall management system of the enterprise. Particular attention is paid to the formulation of a general conceptual approach to risk management, which should be sustainable for all economic systems and focuses on a number of factors that distinguish the practice of domestic enterprises from Western ones that prevent domestic enterprises to fully implement the concept of risk management. own activities. Among such factors are highlighted in the first place: corruption of the government, the shadow economy, concealment of income, fictitious transactions, laundering of value added tax and more. The strategy and tactics of risk management at the enterprise are formulated, as well as the system of goals, such as: maximum preservation of own funds; minimizing the negative impact of internal and external factors; increasing financial stability and improving risk management mechanisms; increasing accountability to investors and counterparties. The stages of risk management in the risk management system of the enterprise are highlighted and a number of losses that enterprises will receive in the absence of a risk management system in the general enterprise management system are described. Among the main losses are: material, financial, time loss and special types of losses. A number of advantages are described that the company has an effectively established system of risk management: awareness of the nature of risks and the inevitability of their occurrence in the management process; reduction of the uncertainty factor in carrying out business activities; growth of business reputation of the enterprise; improving the quality of information for business decisions, etc.
ACTIVITY ANALYSIS OF TOURISM SUBJECTS IN ZHYTOMYR REGION
Authors:   Polissia National University, Chernyshova Taisiia , Valinkevych Nataliia ,   Polissia National University, Mutasova Snizhana ,   Polissia National University
Published: May 2022

The article analyzes the activities of tourism entities in Zhytomyr and Zhytomyr region on the basis of a survey and static analysis of data from the Main Department of Statistics of Ukraine for 2020. The state and level of development of the market of tourist services of Zhytomyr at the level of both consumers and performers is characterized. Based on the analytical review of consolidated statistics on the activities of tour operators and travel agencies in Zhytomyr region and the results of the survey, it was concluded that Zhytomyr region occupies a weak position in the national market of tourism services, both in number of registered tour operators and travel agencies and by the number of sold tourist packages. It was found that only passive tourism is developing in the region, ie the departure of tourists abroad. Zhytomyr region "exports" tourists to other countries. And the most popular for recreation are countries such as Egypt and Turkey (budget option for family vacations). Such dynamics negatively affect the development of both regional and national tourism market and related industries of the country. Such statistics coincide with the results of the survey. It was found that the family budget for vacation ranges from 20 to 40 thousand hryvnias (93% of respondents) per family. Only 7% of respondents spend more than 50 thousand hryvnias on vacation. Such results are in good agreement with the answers regarding the choice of countries for recreation. As a result of the survey, it was found that the leaders among tour operators are: Anex Tour, Join UP and Coral Travel. Thus, tour operator and travel agency activities in the Zhytomyr region are poorly developed. There, Zhytomyr region ranks 17th with the number of tour packages sold 2215. This is a very low figure for the whole region. The region is dominated by outbound tourism. It is the focus on the development of domestic tourism that should be a priority for the development of tourism in the region. Effective implementation of tours in the country and region, and not just the sale of tour packages for holidays abroad, should become the dominant task of travel companies in the region. Such tours will provide quality and inexpensive recreation, promote long-term prosperity and development of the local community and improve the profitability of small and mediumsized businesses.
THE MECHANISMS OF TRANSITION TO THE INNOVATIVE TYPE OF SOCIO-ECONOMIC DEVELOPMENT OF THE REGION
Authors:   Yuriy Fedkovych Chernivtsi National University, Antokhov Andriy , Klevchik Leonid ,   Yuriy Fedkovych Chernivtsi National University, Luste Olena ,   Yuriy Fedkovych Chernivtsi National University
Published: May 2022

Research as elements of the formation of the national innovation system of existing and promising mechanisms for the transition to an innovative scenario for the development of economic and social sectors at the regional level determines the need to analyze the processes of implementation of state innovation policy in a regional projection and study different points of view on, which infrastructural elements of the development of innovation activity in the economic and social sectors of a particular subject can serve as generally accepted mechanisms for the transition to the formation of regional innovation systems. The innovative type of socio-economic development of territories is defined as the formation of long-term multi-level relations between socio-economic entities based on the ideology of innovation culture, which ensures the creation and implementation of innovations in all spheres of life, as well as an increase in intellectual capitalization as a condition for sociodominant self-development. The goals of the regional innovation system have been developed. The general goal is to increase the competitiveness of the regional economy, the goals of the first level are the formation of regional clusters, the system of strategic planning and programming, the mechanism of public – private partnership, the development of territories, the reform of education, health and housing, the development of small and medium-sized innovative businesses. It is determined that the main documents regulating the issues of innovative development at the regional level are: strategies of regional socio-economic development, laws on innovation, regional target programs for innovation development. This article explains the purpose of the innovative type of society and region, found a new meaning of innovative development of the region. Selected the main effects of innovative development of regions of Ukraine, education and employment. Defined the functional significance of the regional economy in the context of stimulation of innovative development processes. The competitiveness of the regional economy is determined on the basis of a rational combination of economic and civic position with state and social justice.
MANAGEMENT OF EMPLOYEE MOTIVATION AS A DIRECTION OF SOCIAL RESPONSIBILITY OF THE ENTERPRISE
Authors:   Poltava State Agrarian University, Shulzhenko Iryna , Maslak Iryna ,   Poltava State Agrarian University, Pavluchenko Oleksii ,   Poltava State Agrarian University
Published: May 2022

The article examines the features of employee motivation management in a modern enterprise, in particular through the application of the principles of social responsibility. It is proved that motivation management is an integral part of general management. Corporate social responsibility is an urgent need, which is an important part of the management process that can improve both the health of employees and the relationship with stakeholders. It is clear that this is extremely important, in particular for optimizing managerial influences on employees. To do this, it is necessary to apply appropriate methods and forms of employee motivation management. Today, many companies and organizations are increasingly aware of the importance and competitive advantages of socially responsible business, the implementation of social functions in the management of staff motivation. As a result of the unstable economic situation, the volume of social activity has significantly decreased. Therefore, the application of the concept of social responsibility in the management of the organization, which provides actions aimed at supporting and developing employees, including care for their health, is becoming more relevant. At the same time, staff health within the concept of corporate social responsibility is considered the most important motivational resource. Therefore, health management can be considered a modern method of motivational management, which helps to stimulate employees and minimize costs. Thus, health management as a measure to promote health in the workplace should become an integral part of motivation management based on the concept of social responsibility, which allows employees to strengthen control over their health. Systematic implementation of such programs in practice will help to strengthen the health of the working population and reate a favorable social climate in the enterprise and increase the efficiency of its activities. This affects the forms and methods of staff motivation, their attitude to work and is an important factor that contributes to improving the efficiency of the enterprise.