bluuebunny/crossref_metadata_2025 huggingface dataset:
COMPENSAÇÃO DE ALIMENTOS: O QUE NOS REVELA A PESQUISA EMPÍRICA?
Authors: Correia Atalá , Benetello Rhayssa
Published: November 2024

A prestação de alimentos, devida por um familiar a outro, tem origens remotas e longa tradição jurídica. O presente artigo identifica essas origens, indicando que desde cedo impediu-se a compensação das prestações alimentares. O ordenamento jurídico brasileiro, e de diversos outros países, proíbe a compensação de alimentos. Esta regra consolidou-se nos artigos 373, II, e 1.707, ambos do Código Civil. Entretanto, a jurisprudência vem criando exceções a esta regra. Buscou-se, portanto, identificar essas exceções, sua justificação e outras características de recente jurisprudência brasileira, por meio de pesquisa empírica. Foram selecionados 36 precedentes do Superior Tribunal de Justiça, delineando-se suas principais características. Descortinou-se inovação judicial perante regra imemorial. A exceção é feita sob o argumento de se vedar o enriquecimento sem causa. A prática revelou-se justa porque bem circunscrita às despesas que revelavam essencialidade para a sobrevivência dos credores, notadamente gastos com saúde, educação e moradia. Foi necessário escrutinar as decisões também sob perspectiva de gênero, traçando-se desafios para o avançar da discussão.
Il problema dei c.d. apolidi de facto e della loro tutela
Authors: Balboni Marco , Korcari Barbara
Published: November 2024

L’articolo si sofferma sulla nozione internazionale di apolidia, ancora non interamente condivisa. Mentre infatti non vi è dubbio che ricomprenda la c.d. apolidia de jure, si discute se la nozione internazionale di apolidia possa ricomprendere anche la c.d. apolidia de facto, ovvero la condizione di persone che, per varie ragioni o motivi, pur possedendo formalmente una nazionalità o avendo una fondata aspettativa di possederla, si trovano di fatto in una condizione del tutto simile a quella in cui si trovano le persone c.d. apolidi de jure.
Dopo aver riscostruito brevemente la codificazione in ambito internazionale in materia di apolidia, l’articolo ricostruisce il dibattito che si è avuto in sede internazionale sulla questione in esame, prima in relazione alla codificazione delle due convenzioni specifiche adottate in materia di apolidia e, quindi, nel dibattito successivo, per poi tentare qualche conclusione. E’ opinione degli autori che la nozione di apolidia de facto meriti di essere mantenuta al fine di disegnare una categoria di persone che, in ragione della loro specifica condizione, possano avere diritto a beneficiare sia del regime di protezione previsto per gli apolidi de jure, sia dei diritti associati alla cittadinanza, alla luce in particolare delle garanzie fornite dal diritto internazionale dei diritti umani, e ciò, probabilmente, in base a una scelta individuale dipendente da un apprezzamento personale della propria situazione, in considerazione delle circostanze di ciascun caso concreto. Il problema semmai è quello di rafforzare gli strumenti internazionali di tutela a disposizione, particolarmente deboli in materia di apolidia.
La propiedad de los restos del R.M.S. Titanic. Análisis de Derecho internacional privado
Authors: Carrascosa González Javier
Published: November 2024

El presente estudio tiene por objeto explorar el sistema de Derecho internacional priva­do británico, estadounidense y español que resulta aplicable para decidir la propiedad de los restos del H.M.S. TITANIC. El examen de los varios y realmente poco útiles instrumentos legales internacionales que se ocupan del régimen jurídico sobre la propiedad de los bienes que integran un pecio arroja un resultado desolador, carente de soluciones de Derecho Privado. Este trabajo defiende que la propiedad del TITANIC debe atribuirse al sujeto que en mayor medida pueda rescatar los bienes del pecio y pueda exponerlos a toda la Humanidad. En dicha perspectiva, es el Derecho internacional privado norteameri­cano el que resulta más competitivo, al atribuirse la propiedad al salvador de los bienes.
La necesaria protección jurídica internacional del patrimonio histórico-artístico y cultural en Derecho internacional privado español
Authors: Ortega Giménez Alfonso
Published: November 2024

En un mundo globalizado, el patrimonio cultural es fundamental para la identidad y la memoria colectiva de una sociedad, y su preservación es un objetivo compartido entre distintas sociedades. A continuación, se analiza la importancia de la protección jurídica internacional del patrimonio histórico-artístico y cultural en el ámbito del Derecho Internacional Privado español, con un enfoque particular en el Caso Cassirer. Dicho caso involucra una reclamación de la familia Cassirer por la restitución de un cuadro de impresionante valor cultural, “Rue Saint-Honoré, après-midi, effet de pluie” de Camille Pissarro, que fue saqueado por los nazis durante la Segunda Guerra Mundial. Este estudio resalta la importancia de la cooperación internacional y la armonización legal en la protección del patrimonio cultural, y promueve ejemplos prácticos sobre disputas de restitución de obras de arte saqueadas durante conflictos históricos, que plantean desafíos complejos en el ámbito legal.
Caso superliga
Authors: Rodríguez Rodrigo Juliana
Published: November 2024

En la sentencia objeto de comentario, el TJUE responde a las cuestiones prejudiciales planteadas por el Juzgado de lo Mercantil número 17 de Madrid en el caso de la demanda interpuesta por la Superliga contra la FIFA y la UEFA. En estas cuestiones se pregunta si la decisión de estas dos entidades de no autorizar la celebración de la Superliga en sus mercados de actuación vulnera las normas de competencia, además de las libertades europeas. El Tribunal de Justicia concluye que sí. Indica que, en relación con las normas de competencia, que son las objeto de estudio en este trabajo, este comportamiento de la FIFA y la UEFA supone un abuso de la posición de dominio que ostentan estas empresas, al impedir la entrada de nuevos competidores en el mercado (art. 102 TFUE) y, también, como asociaciones de empresas, su conducta lesiona por objeto la competencia de sus asociados (art. 101.1 TFUE) y no puede quedar exenta de la sanción, entre otras razones, por la ya comentada de impedir la entrada de nuevos operadores al mercado (art. 101.3 TFUE).
Association Between IFN-λ4 rs12979860 And rs11322783 Polymorphisms with Spontaneous Clearance In Chronic Hepatitis B
Authors: Özkan Fariz Emrah , Dalkılıç Semih , Kadıoğlu Dalkılıç Lütfiye , Şahin Abdurrahman , Bahçecioğlu İbrahim Halil , Yalnız Mehmet
Published: November 2024

Many studies have been published on the association between IFN-λ3 and IFN-λ4 polymorphisms and treatment related or spontaneous clearance of chronic hepatitis C. To date there is little known about the impact of IFN-λ4 polymorphisms on the natural history of chronic hepatitis B(CHB). This study aimed to investigate the role of IFN-λ4 polymorphisms on the course of CHB and to influence the presence of spontaneous clearance (SC) in CHB patients. One hundred and twenty-two patients who had CHB, and 81 subjects who had spontaneous resolution of HBV were analyzed regarding IFN-λ4 rs12979860 and rs11322783 single‑nucleotide polymorphisms. We couldn’t found any significant difference between CHB groups and SC groups in terms of IFN-λ4 rs12979860 polymorphisms and, the CC, C/T and TT genotypes represented 49%, 45% and 5% of CHB patients and, %46, 43% and 11% of SC group respectively (p=0.65). On the other hand, in IFN-λ4 rs11322783 polymorphisms analysis, recessive G/G allele was more common in SC group compared to CHB group (5% vs 16%, p=0.04; OR: 3,55). Moreover, non-G/G genotypes had significantly higher in CHB patients compared to SC group (95% vs 84%, p=0.013; OR:3.55). Our results suggest that IFN-λ4 rs11322783 polymorphism may be a predictor of spontaneous clearance in HBV infected patients. The role of IFN-λ4 polymorphisms needs to be investigated in the natural history of HBV.
CORRELATION OF Trichomonas vaginalis INFECTION AND PROSTATE CANCER: A SYSTEMATIC REVIEW
Authors: Larissa Melo Ferreira dos Santos Mayara , Wanesssa Melo França Wilza , Gabriele Marques Diniz Emily , Victor Ritinto da Rocha João , Stéphanny de Souza Silva Maria , Ricardo Correia do Nascimento Wheverton , Arely Milca Fagundes Silva Hianna Arely Milca Fagundes Silva , José da cruz filho Iranildo , Camelo Pessoa de Azevedo Albuquerque Mônica , Douglas Andrade de Araújo Hallyson , Lima Aires André
Published: November 2024

Introduction: The presence of T. vaginalis in men should be investigated in terms of its ability to trigger inflammatory reactions and tissue changes capable of damaging the prostatic tissue. Objective: To assess whether there is a correlation between T. vaginalis infection and the risk of developing prostate cancer through systematic investigation. Methodology: To obtain the original studies, crosses were made between the descriptors in Health Sciences and Free Terms, in English and Portuguese, in the databases without limitation for the year of publication. Result: Of the nine articles used, four indicate the association of T. vaginalis infection with developing a malignant prostatic tumor. However, we emphasize the lack of studies with larger population groups and more specific and sensitive methodologies. Conclusion: We emphasize that seven articles were conducted with men residing in the United States, therefore, studies with the male population of other countries are fundamental for a better understanding of the association of T. vaginalis infection with the development of prostate cancer.
Observational Studies of Exposure to Tobacco and Nicotine Products: Best Practices for Maximizing Statistical Precision and Accuracy
Authors: Cohen Gal , Cook Steven
Published: November 2024

This review explores methodological considerations for maximizing the precision and accuracy of observational cohort studies assessing the risk profiles of tobacco and nicotine products. These considerations, informed by the ROBINS framework for minimizing statistical bias, are anchored in a comprehensive characterization of exposure to all tobacco products currently or formerly used, with corroboration of dose-response relationships. Best-practice considerations for non-randomized observational studies of exposure are enumerated, to most precisely and accurately inform future waves of databases, studies and meta-analyses. These principles are then considered within the context of a recent comprehensive meta-analysis, representing 107 observational studies, which evaluated the health effects of using electronic cigarettes (EC) compared to non-use, use of combusted cigarettes (CC) and dual-use of both products (DU). The meta-analysis had previously reported the relative risk from all-sources, including tobacco use and non-tobacco use. We now report the magnitude of risk reduction associated with displacing CC use with EC use indicated from the primary references, along with considerations regarding the precision of characterization of dose, duration, and timing of CC and EC use in the cited studies.
Mutual Neutralization in Collisions of Li with O-+
Authors: Larson Åsa , Orel Ann E.
Published: November 2024

The total and differential cross sections and final state distribution for mutual neutralization in collisions of Li+ with O− have been calculated using an ab initio quantum mechanical approach based on potential energy curves and non-adiabatic coupling elements computed with the multi-reference configuration interaction method. The final state distributions favor channels with excited oxygen states, indicating a strong effect of electron correlation, and the electron transfer cannot be described by a simple one-electron exchange process.
Adaptive Transverse Laser Shaping and Its Application in a Photocathode Gun
Authors: Liu Zhongqi , Jia Haoyan , Xu Hang , Xu Jinqiang , Huang Senlin
Published: November 2024

In a high-brightness photocathode gun, the non-uniformity in both the transverse distribution of the photocathode drive laser and the quantum efficiency (QE) map can lead to a degradation in electron beam quality. This study explores an adaptive transverse laser shaping technique and its application to improve the uniformity of the electrons emitted from the photocathode. By utilizing a spatial light modulator (SLM) with a feedback algorithm, we effectively control the drive laser distribution and achieve single-shot QE map measurement and QE compensation. The experiments conducted on the DC-SRF-II gun demonstrate a rapid and efficient QE measurement process, as well as a notable improvement in electron beam uniformity. Our study offers a promising approach for improving beam quality in accelerator applications that demand high-brightness electron sources.
On the Twistability of Partially Coherent, Schell-model Sources
Authors: Borghi Riccardo
Published: November 2024

The problem of assessing the twistability of a given bonafide cross spectral density is here tackled for the class of Schell-model sources whose shift invariant degree of coherence is represented through a real and symmetric function, say μ(−r)=μ(r). On employing an abstract operatorial language, the problem of the determination of the, highly degenerate spectrum of a twisted operator W^u is addressed through a modal analysis based on the complete knowledge of the spectrum of the sole twist operator T^u found by Simon and Mukunda [J. Opt. Soc. Am. A 15, 1361 (1998)]. To this end, the evaluation of the complete tensor of the matrix elements 〈n′,ℓ′|W^u|n,ℓ〉 is carried out within the framework of the so-called extended Wigner distribution function, a concept recently introduced by Van Valkenburgh [J. Mod. Opt. 55, 3537 - 3549 (2008)]. As a nontrivial application of the algorithm here developed, the analytical determination of the spectrum of saturated twisted astigmatic Gaussian Schell-model sources is also presented.
Granitoid Mapping with Convolutional Neural Network and ASTER VNIR-SWIR Data: A Case Study of the Western Junggar Orogen
Authors: Zheng Shuo , Zhou Yarong , An Yanfei , Cui Xiangyu , Shi Pilong
Published: November 2024

The Western Junggar Orogen (Xinjiang) is featured by widespread granite intrusions and vast Au-Cu-Mo resource, making it an ideal site to study granitoids and their metallogenic link. Here, we utilized spectral information, remote sensing imaging and statistics, and textural features to select band combinations from ASTER VNIR-SWIR data. These combinations serve as the input layers for convolutional neural networks (AlexNet, VGG16 and GoogLeNet), which are used for remote sensing identification of granitoid lithology, and the results were compared with the Landsat 8 data. We suggest that the AlexNet model can best identify granitoid subtypes in the Western Junggar, with the 9B+T1 band combination being the most accurate (best weighted F1 score: 91.98%; kappa coefficient: 0.84). Landsat 8 images performed poorly, possibly because they have only two SWIR bands. The best lithological mapping results have identified Cu-Au ore-related diorite in the Karamay III intrusion, I-type granite in the Hongshan intrusion related to quartz vein-type and magmatic-hydrothermal gold ores, as well as A-type granite in the Akbasito and Karamay I and II intrusions. Our findings offer detailed spatial distribution characteristics of granite subtypes and provide remote sensing exploration methods for studying polymetallic ore belts in the Central Asian Orogenic Belt.
Evaluating the Role of Open Innovation and Circular Economy in Enhancing Organizational Performance: Insights from Batik SMEs in Banyuwangi Indonesia
Authors: Rahmat Dana Azizah , Rumanti Augustina Asih , Pulungan Muhammad Almaududi , Rizaldi Artamevia Salsabila , Amelia Mia
Published: November 2024

Batik SMEs, as key contributors to Indonesia’s heritage and economy, their inability to fully harness innovative and sustainable practices threatens not only their survival but also their contribution to economic. However, their path to sustainability is hindered by many limitations in adopting circular economy (CE) principles, a framework widely acknowledged to enhance organizational perfor-mance. This study examines and evaluate the application of innovation within Indonesia's batik SME sector, focusing on the simultaneous impact of open innovation and circular economy princi-ples—an area that has been largely unexplored within this specific sector. Our study analyzed the influence of open innovation and circular economy on organizational performance measured sim-ulant among 70 Batik SMEs in Banyuwangi, Indonesia, using Structural Equation Modeling-Partial Least Square (SEM-PLS). The results reveal that while both open innovation and CE enhance performance, some dimensions of CE—such as waste reduction—proved less relevant to the business models of Batik SMEs based on model iteration. Moreover, this includes a discussion about several elimination items within the iteration. These findings suggest that Batik SMEs benefit more from resource optimization and innovation networks than from rigid waste management practices. In conclusion, integrating open innovation with tailored circular economy strategies can improve the operational efficiency and sustainability of Batik SMEs, enabling them to better compete and grow. This research highlights the need for context-specific adaptations of CE principles to ensure their practical impact on different sectors, emphasizing the role of innovation in overcoming resource limitations.
Research Progress of Artificial Intelligence in Intelligent Fisheries Breeding in Prediction and Health Management Systems
Authors: Yang Duo , Chen Xin , Sun Xiang , Tan Gaoce
Published: November 2024

The research presented in this review highlights the critical importance of integrating Artificial Intelligence (AI) in aquaculture to enhance efficiency, sustainability, and fish health management. Current aquaculture practices face significant challenges, such as data quality issues, incomplete and noisy data, and the complexity of managing diverse environmental and biological factors affecting fish health. To address these challenges, the review explores advanced AI methodologies, including deep learning, the Internet of Things (IoT), and data fusion techniques, to develop robust predictive and health management (PHM) systems in aquaculture. The study summarizes various AI-based approaches for real-time monitoring, disease detection, and optimized feeding strategies, which improve the overall management of aquaculture operations. These methods involve the use of high-precision sensors, automated image and acoustic data acquisition, and sophisticated data preprocessing and integration techniques. Collectively, these techniques aim to ensure accurate, real-time monitoring and predictive analysis of fish health and environmental conditions. The research findings demonstrate the successful application of AI techniques in achieving significant improvements in fish growth rates, reducing environmental impact, and enhancing operational efficiency. For example, AI-driven PHM systems have shown high detection accuracy and efficient management of feed and water quality parameters, leading to better fish health outcomes and lower mortality rates. In conclusion, the integration of AI in aquaculture presents a transformative approach, offering valuable insights and practical solutions for sustainable and intelligent fish farming. The study underscores the value of AI in enhancing predictive capabilities, optimizing resource use, and ensuring the ecological sustainability of aquaculture practices, thereby contributing to the growing global demand for efficient and sustainable fish production systems.
Multi-Modal Deep Learning Architecture for Improved Colposcopy Image Classification
Authors: Chatterjee Priyadarshini , Siddiqui Shadab
Published: November 2024

Colposcopy image classification is vital for early cervical cancer detection, yet it remains challenging due to the significant variation in lesion appearances. Although deep learning models have advanced medical image classification, few studies have explored combining different model architectures to enhance diagnostic accuracy in colposcopy. This study addresses this gap by proposing a lesion-specific, multi-branch architecture that integrates attention mechanisms, deep feature extraction, and ensemble learning. Multi-task learning is employed to manage multiple lesion-specific classification tasks, while an ensemble of classifiers—Logistic Regression, XGBoost, and CatBoost—enhances decision-making accuracy. The architecture includes deep learning branches using EfficientNetB0 and MobileNetV2 for rich feature extraction from colposcopy images, with their outputs combined through a soft voting ensemble. Hyperparameter tuning, k-fold cross-validation, PCA visualization, and AUC plots for multiclass performance were used to optimize and assess model effectiveness. Training and validation accuracy were tracked in two phases: after the training phase, training accuracy reached 97.85\% and validation accuracy was 97.33\%; after the final ensemble classification, training accuracy improved to 99.95\% and validation accuracy to 99.85\%, surpassing individual model performance and demonstrating enhanced generalization. This model shows substantial promise for improving colposcopy classification accuracy, providing a valuable tool for clinical decision support in cervical cancer diagnosis.
Graph-based Analysis for the Characterization of Corrugated Boards Compression
Authors: Belfekih Taieb , Fitas Ricardo , Schaffrath Heinz-Joachim , Schabel Samuel
Published: November 2024

This paper proposes a novel approach to represent the geometry of the corrugated board profile during compression by using graphs. Graphs are lighter than images, and the computational time of compression analysis is then significantly reduced compared to using the original image data for the same analysis. The main goal of using such graphs is to gain more knowledge about the mechanical behavior of corrugated boards under compression compared to the current load-deformation curve approach. A node-tracking algorithm is applied to characterize the different phases happening during the compression test in order to predict physical phenomena, including buckling and contact. The main results show that analyzing the nodes provides significant insights into the compression phases, which was not achieved in the current state-of-the-art. The authors believe the object of this research is crucial to better understand the physics of corrugated boards under compression, and it can also be extended to other engineering structures.
Innovative Drill Design with the Development of Sensors for the Analysis of Cutting Forces in Metalworking Conditions
Authors: Traistaru Elena Dalina , Kassenov Assylbek , Mussina Zhanara , Taskarina Aizhan , Mussina Leila , KORKA Zoltan
Published: November 2024

Instrumental production is a crucial component of industrial and innovative development in the metalworking industry, where the drilling process plays a key role. Traditional twist drills with conventional cutting-edge designs, including a transverse edge, face several issues during drilling, such as difficult chip evacuation and high friction between the tool and the workpiece. These phenomena, in turn, lead to a deterioration in the quality of machined holes and a reduction in tool life. Existing methods of drill geometry modification only partially address these problems by reducing axial forces and increasing tool durability, but they do not provide a comprehensive improvement of the drilling process overall. The aim of this study is to develop and examine a new drill design—a double-point twist drill without a transverse edge, which ensures favorable cutting conditions, reduces tool wear, and increases tool durability during the drilling process. In the course of the study, experimental samples of the double-point drill were manufactured at the machine-building company LLP «Format Mach Company» (Pavlodar). For the experimental tests, a setup was developed that included the ZET 058 strain gauge system and Kistler piezoelectric force sensors. This combination allowed for a detailed investigation of cutting forces in a dynamic mode and recorded the loads acting on the tool in various directions, contributing to an objective evaluation of its performance. The experimental results showed that the double-point drill without a transverse edge significantly improves the drilling process by reducing axial and radial cutting forces, which helps to reduce tool wear and increase drill durability. This confirms the feasibility of applying this drill design to enhance the quality of hole machining and the efficiency of production processes in the metalworking industry. An increase in the durability of the new tool - a double-point twist drill without a transverse edge - was established at 2.2 times.
Spectroscopy-Based Methods and Supervised Machine Learning Applications for Milk Chemical Analysis in Dairy Ruminants
Authors: Agiomavriti Aikaterini-Artemis , Nikolopoulou Maria P. , Bartzanas Thomas , Chorianopoulos Nikos , Demestichas Konstantinos , Gelasakis Athanasios I.
Published: November 2024

Milk analysis is critical to determine its intrinsic quality, as well as its nutritional and economic value. Currently, the advancements and utilization of spectroscopy-based techniques combined with machine learning algorithms have made feasible the development of analytical tools and re-al-time monitoring and prediction systems in the dairy ruminant sector. The objectives of the cur-rent review were i) to describe the most widely applied spectroscopy-based and supervised ma-chine learning methods utilized for the evaluation of milk components, origin, technological properties, adulterants, and drugs residues, ii) to present and compare the performance and adaptability of these methods and their most efficient combinations, providing insights into the strengths, weaknesses, opportunities, and challenges of the most promising ones regarding the capacity to be applied in milk quality monitoring systems both at the point-of-care and beyond, and iii) to discuss their applicability and future perspectives for the integration of these methods in milk data analysis and decision support systems across the milk value-chain.
A W-Band Real-Time Imaging Mini-SAR System for Unmanned Aerial Vehicles
Authors: Tang Li , Wang Yinshen , Qu Jiameng , Wang Xuemei , Ding Manlai , Liang Junli
Published: November 2024

The synthetic aperture radar (SAR) mounted on unmanned aerial vehicles (UAVs) can efficiently and rapidly acquire high-resolution geographic remote sensing data. However, the limited payload capacity and power consumption of UAVs present a challenge for the application of traditional SAR real-time imaging processing platforms based on DSP or GPU. In this paper, a real-time processor that utilizes the Xilinx Zynq Ultrascale+ZU9EG MPSoC is proposed and successfully applied to a W-band Mini-SAR system. Several essential technologies, including SAR data preprocessing, high-energy-efficient real-time processing, and lightweight motion compensation, are utilized to develop the real-time processing Mini-SAR for use in small UAVs. The total weight of the entire system is only 724 grams, and its power consumption is 38.3 watts. During the UAV flight test, the system is capable of producing SAR images with a resolution of 0.1 meters at a size of 4K x 4K in just 4.5 seconds. The discrepancy between the imaging results and the ground post-processing is less than 10-4.
Statistical Properties of Superpositions of Coherent Phase States with Opposite Arguments
Authors: de Freitas Miguel Citeli , Dodonov Viktor V.
Published: November 2024

We calculate the second-order moments, the Robertson–Schrödinger uncertainty product and the Mandel factor for various superpositions of coherent phase states with opposite arguments, comparing the results with similar superpositions of the usual (Klauder–Glauber–Sudarshan) coherent states. We discover that the coordinate variance in the analog of even coherent states can show the most strong squeezing effect, close to the maximal possible squeezing for the given mean photon number. On the other hand, the Robertson–Schrödinger (RS) uncertainty product in superpositions of coherent phase states increases much slower (as function of the mean photon number) than in superpositions of the usual coherent states. A nontrivial behavior of the Mandel factor for small mean photon numbers is discovered in superpositions with unequal weights of two components. An exceptional nature of the even and odd superpositions is demonstrated.
Trace Dynamics, Octonions, and Unification: An E_8 X E_8 Theory of Unification
Authors: Singh Tejinder
Published: November 2024

This is a very brief overview of the ongoing research program of unification known as the octonionic theory. We highlight the quantum foundational origins for the theory, and the seven key ingredients which go into its making.
Taurin Amino Asidinin Obezite ve Yağ Doku Üzerindeki Etkileri
Authors: Büyükdere Yücel , Akyol Mutlu Aslı
Published: November 2024

Obezite, sıklığı gittikçe artan ve ciddi sağlık sorunlarına yol açan metabolik bir rahatsızlıktır. Vücutta sağlığı bozabilecek düzeyde yağ birikimi obezitede gözlenen temel sorundur. Yağ miktarındaki artışın yanı sıra yağ dokudan salgılanan sinyal molekülleri ve adipokin salınımında değişiklikler, enerji metabolizmasının regülasyonunda bozulmalar, lipid ve glikoz homeostazisi bozuklukları da obezitede gözlenmektedir. Kükürtlü bir amino asit olan taurinin obezite üzerindeki etkileri son yıllarda tartışma konusu olmuştur. Taurinin; obezite durumunda ortaya çıkan bu metabolik bozukluklar üzerindeki olumlu etkileri, sitolojik, histolojik ve biyokimyasal düzeyde yapılan çalışmalarla farklı mekanizmalar üzerinden gösterilmiştir. Ancak; son zamanlarda obezite tedavisinde araştırılan beyaz yağ doku kahverengileşmesi üzerinde taurinin etkinliği ise belirsizliğini korumakta olup bu konuda kapsamlı çalışmaların yapılmasına ihtiyaç duyulmaktadır. Bu derlemede, taurinin obezite ve yağ doku üzerinde hangi mekanizmalarla etki ettiği ele alınmıştır.
Self-cleaning e exclusão obrigatória de operadores econômicos: uma análise comparativa entre a Diretiva 2014/24/UE e a lei de licitações brasileira
Authors: Puerari Adriano Farias , Vieira Lucas Pacheco
Published: November 2024

Public procurement plays a fundamental pillar as an instrument able to ensure a more efficient use of public resources. In the context of European Union, the Directive 2014/24/UE of the European Parliament and the Council, which takes care of public procurement, made notable changes in relation to the causes of exclusion of economic agents from participating in contracting procedures. In Brazil, New Public Procurement and Administrative Contracts Law, Law n. 14.133/2021, also promoted changes in relation to the sanctioning scope and the possibilities of rehabilitation of companies. In this way, the objetive of this article is, in the light of the principle of competition, analyze the limits of the restriction clauses required from the design of Self-Cleaning, as an institute of community law able to relativize the expulsion grounds set out in the Directive, relating them to the new Brazilian legislation. The comparison between the legislations shows that while Europe has an established and detailed system for self-cleaning, the Brazilian approach is still maturing and could benefit from European practices to strengthen public policies through mechanisms for the reintegration of economic operators. The conclusion is that the experience observed through the Directive can contribute to Brazil's public procurement system, optimizing transparency, competitiveness, and especially, integrity in public contracting processes.
Radiographic Assessment of Bone Union in Proximal Tibia and Distal Femur Osteotomies
Authors: Bax Eva A. , Harlianto Netanja I. , Custers Roel J.H. , van Egmond Nienke , Foppen Wouter , Kruyt Moyo C.
Published: November 2024

Background:

Osteotomies around the knee are a well-established treatment option for early and moderate unicompartmental osteoarthritis combined with a lower extremity malalignment. Moreover, osteotomies are often combined with cartilage treatment. Current image-based bone union assessments lack an accepted definition despite widespread use in research and clinical settings. The aim of this systematic review was to identify definitions and classification systems for bone union on radiographs after a proximal tibia or distal femur osteotomy.

Methods:

Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we systematically searched MEDLINE and Embase database, applying specific inclusion and exclusion criteria. Two independent reviewers screened abstracts and full-texts. The modified Cochrane Risk of Bias Tool and Risk of Bias in Nonrandomized Studies of Interventions tool were used. Data extraction included study characteristics, imaging modality, bone union definition, classification systems, assessment of gap fillers, use of modifiers, and osteotomy type.

Results:

Of the 1,180 screened titles and abstracts, 105 studies were included, with the majority (69 studies [65.7%]) using a retrospective design. Fifty-five studies (52.4%) defined bone union based on one or more criteria, while 50 studies (47.6%) used a classification system. There were 13 different criteria for bone union and 9 different classification systems. Interestingly, none of the classification systems incorporated negative criteria, such as hardware failure. Notably, 137 studies (49.1%) described bone union as either a primary or secondary outcome but do not describe a system for assessing bone union.

Conclusion:

This systematic review highlights the lack of consensus in the literature in defining bone union after a proximal tibia or distal femur osteotomy, revealing many criteria and different classifications. None of the classification systems were applicable to osteotomies with and without gap filler. This systematic review shows the need for a straightforward, reproducible, and accurate method to assess bone union after a proximal tibia or distal femur osteotomy.

Level of Evidence:

Level III. See Instructions for Authors for a complete description of levels of evidence.
Time-series forecasting methods : a review
Authors: Fisher Andmorgan , Hodgdon Taylor , Lewis Michael
Published: November 2024

Time-series forecasting techniques are of fundamental importance for predicting future values by analyzing past trends. The techniques assume that future trends will be similar to historical trends. Forecasting involves using models fit on historical data to predict future values. Time-series models have wide-ranging applications, from weather forecasting to sales forecasting, and are among the most effective methods of forecasting, especially when making decisions that involve uncertainty about the future. To evaluate forecast accuracy and to compare among models fitted to a time series, three performance measures were used in this study: mean absolute error (MAE), mean square error (MSE), and root-mean-square error (RMSE).
Representasi Ideologi Feminisme Pada Film Sri Asih Karya Joko Anwar
Authors: Hikam Ahmad Ilzamul
Published: November 2024

Film Sri Asih sendiri telah menjadi simbol feminisme bagi perempuan di layar kaca maupun layar lebar. Karakter Sri Asih sendiri tidak hanya menunjukan kekuatan fisik, tetapi juga kepemimpinan, kepintaran, dan seluruhnya karakter yang memegatkan stereotip gender. Sri Asih menjadi simbol perempuan yang kuat, mandiri, dan menentang ketidaksetaraan gender. Film Sri Asih memberikan dampak positif dalam mersapi budaya popular dengan kesetaraan gender, memberikan arahan kepada  penonton untuk meresapi dan mencari tahu aturan patriarki yang telah lama melekat  di lingkungan masyarakat. Sri Asih bercerita mengenai Alana yang tidak mengerti mengapa dia selalu dikuasai oleh kemarahan, tapi ia selalu berusaha untuk melawannya. Alana lahir pada saat letusan gunung berapi yang membuat ia terpisah kepada kedua orang tuanya. Alana kemudian diadopsi oleh ibu Sarita yaitu perempuan kaya yang berusaha membantunya untuk hidup normal. Namun, pada saat Alana tumbuh dewasa ia menemukan kebenaran tentang asalnya bahwa ia bukan manusia biasa. Ia dapat menjadi kebaikan pada kehidupan dan menjadi kehancuran apabila ia tidak dapat meredam amarahnya. Berdasarkan hasil analisis data, ditemukan dua aliran dalam film Sri Asih. Kedua aliran tersebut adalah feminisme liberal dan feminisme eksistensialis.
Application of Artificial Intelligence Technology for Prompt Diagnosis of Cast Iron Mechanical Properties
Authors: Kutsepau A. Yu. , Kren A. P. , Nikiforov A. V. , Tursunov N. K.
Published: November 2024

Kinetic indentation is widely used to measure physical and mechanical properties of materials as one of the most universal methods for non-destructive testing. This paper uses the latest advances in artificial intelligence and capabilities of the Python programming language libraries allowing to carry out accurate measurements of cast iron hardness based on the data of the material’s micro-impact loading diagram. It has been shown that use of machine learning allows eliminating gross errors and reducing the error of indirect hardness evaluation in several times – down to 10 units according to Brinell HB. It has also been established that formation of additional features for training models (based on traditionally used characteristics: penetration depths, indenter movement speed and contact forces at certain points in time) has a positive effect on the accuracy of measurements, but amount of measurements should also be optimized. Feasibility of effective use of machine learning to evaluate hardness has been demonstrated by comparing of calculated hardness values with data obtained with standard testing methods. Advantage of the developed testing method is the fact that the developed algorithms can be used for prompt diagnostics of cast iron hardness using existing equipment. It is appropriate to extend the proposed approach for determination of other mechanical properties of cast iron: yield strength, strain hardening index, creep, relaxation, determined by indentation methods.
APPROACHES ON SANITATION AND HEALTH IN THE LEGAL AMAZON
Authors: Lucena Regina Cé´lia Borges de , Medeiros Marcílio Sandro
Published: November 2024

The objective of this article is to understand and analyze the approaches employed in study of the relationship between sanitation and health in the Legal Amazon from 2013 to 2023. This article conducts an integrative review of the literature drawing upon the works available in the Scientific Electronic Library Online, Virtual Health Library, and Capes Periodicals. 64 out of 185 studies are analyzed, in line with the research question and after applying the eligibility criteria. The studies are clustered into four thematic categories: (i) occurrence of diseases and injuries; (ii) environmental analysis, which includes studies on the risks of elements present in the soil, water and animals; (iii) technology assessment and proposal of methodologies; and (iv) impact of capitalist expansion. More than half of the studies (56%) refer to the more classic approach, which establishes a relationship between sanitation conditions and the occurrence of diseases and injuries. At the same time, an expansion of theoretical-conceptual approaches to the topic was identified, including a focus on human rights and environmental justice, especially in studies about the impact of capitalist expansion. The results of this research point to the need of improving the critical reflection on the political, economic, and sociocultural determinants inherent to the connections between sanitation and health in Brazil.
Cap analogs with a hydrophobic photocleavable tag enable facile purification of fully capped mRNA with various cap structures
Authors: Abe Hiroshi , Inagaki Masahito , Abe Naoko , Li Zhenmin , Nakashima Yuko , Acharyya Susit , Ogawa Kazuya , Kawaguchi Daisuke , Hiraoka Haruka , Banno Ayaka , Meng Zheyu , Tada Mizuki , Ishida Tatsuma , Lyu Pingxue , Kokubo Kengo , Murase Hirotaka , Hashiya Fumitaka , Kimura Yasuaki , Uchida Satoshi
Published: November 2024

Starting with the clinical application of two vaccines in 2020, mRNA therapeutics are currently being investigated for a variety of applications. Removing immunogenic uncapped mRNA from transcribed mRNA is critical in mRNA research and clinical applications. Commonly used capping methods provide maximum capping efficiency of around 80–90% for widely used Cap-0- and Cap-1-type mRNAs. However, uncapped and capped mRNA possesses almost identical physicochemical properties, posing challenges to their physical separation. In this work, we develop hydrophobic photocaged tag-modified cap analogs, which separate capped mRNA from uncapped mRNA by reversed-phase high-performance liquid chromatography. Subsequent photo-irradiation recovers footprint-free native capped mRNA. This approach provides 100% capping efficiency even in Cap-2-type mRNA with versatility applicable to 650 nt and 4,247 nt mRNA. We found that the Cap-2-type mRNA showed up to 3 to 4-fold higher translation activity in cultured cells and animals than the Cap-1-type mRNA prepared by the standard capping method.
WITHDRAWN: Exploring Adipsin, Irisin, and Osteopontin as Biomarkers in Polycystic Ovary Syndrome and Their Associations with Metabolic Alterations: A prospective, case-control study
Authors: Duzenli Fatma Nur , Yurtcu Engin , Keyif Betul , Basbug Alper
Published: November 2024

The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Disrupting Antimicrobial Resistance: Unveiling the Potential of Vitamin C in Combating Biofilm Formation in Drug-Resistant Bacteria
Authors: Rahim Samiur , Rahman Reazur , Jhuma Tania Akter , Ayub Mustaq Ibn , Khan Shakila Nargis , Hossain Ashfaque , Karim Muhammad Manjurul
Published: November 2024

Background
Antimicrobial resistance (AMR) poses a significant threat to global health, exacerbated by the protective mechanisms of biofilms formed by drug-resistant bacteria. Extracellular polymeric substances (EPS) produced by bacteria in biofilms serve as a formidable shield, impeding the efficacy of antimicrobial agents. Here, we investigate the potential of vitamin C (sodium ascorbate) to disrupt biofilm formation in drug-resistant bacteria isolated from diabetic foot ulcer (DFU) patients and study the antimicrobial and antibiofilm activity of vitamin C on these bacteria.
Result
Out of 117 study isolates, primarily identified as Escherichia coli, Staphylococcus spp., and Klebsiella spp., 80 isolates exhibited a Multiple Antimicrobial Resistance (MAR) index greater than 0.2, classifying them as multi-drug resistant (MDR) superbugs. Among these, 58 isolates demonstrated moderate to strong biofilm-forming abilities and were selected for further experiments with vitamin C. The effective concentration of vitamin C inhibiting the growth of most E. coli and Klebsiella isolates (80%) was estimated at 1.25 mg/ml, while for Staphylococcus spp. isolates, it was 0.325 mg/ml. Vitamin C exhibited a notable anti-biofilm effect against the studied isolates, with biofilm prevention concentrations (BPC) of 0.625 mg/ml, 1.25 mg/ml, and 0.16 mg/ml for E. coli, Klebsiella spp., and Staphylococcus spp. isolates respectively. Furthermore, when combined with oxacillin or amoxicillin - drugs that were found ineffective, vitamin C significantly reduced the ability of MDR isolates to form biofilms, rendering them susceptible to the drugs' effects and restoring their efficacy. The expression of the recA gene, an early and quantifiable marker for the onset of the SOS response and biofilm production was downregulated after treatment of E. coli with vitamin C. Relative gene expression analysis revealed that ciprofloxacin-induced recA expression was significantly inhibited when MDR isolates of E. coli were treated with vitamin C at a concentration of 0.625 mg/ml, the BPC of vitamin C.
Conclusion
Our findings reveal that vitamin C, alone or in combination with ineffective antibiotics, attenuates biofilm formation and restores the susceptibility of multidrug-resistant (MDR) isolates to antimicrobial agents. This study underscores the promise of vitamin C as a non-lethal disruptor of biofilm-associated antimicrobial resistance.
Investigating the relationship between cognitive disorders and fatigue in patients with Parkinson's and its relationship with individual and clinical factors in Isfahan city
Authors: Maghzi Pegah , Nazari Fatemeh , Chitsaz Ahmad , Kouhi Narjes
Published: November 2024

Parkinson's disease is a complex and debilitating disease caused by the degeneration of dopamine-producing brain cells due to the accumulation of α-synuclein, which affects the functioning of the front striatal networks. This research focused on collecting data meticulously by employing various methods. The data gathering process included interviews, examination of medical records, utilizing six checklists, and seeking expert opinions. Valuable insights were obtained from patients' files and input from respected healthcare professionals. Extensive neuropsychological questionnaires were used to thoroughly assess different cognitive areas. Furthermore, demographic details such as age, gender, marital status, education level, and employment status were diligently recorded. Clinical specifics like disease duration, stage, symptoms, medication usage, and sleep patterns were also analysed. The impact of fatigue in physical, cognitive, and psychosocial aspects was measured using the Parkinson's Fatigue Severity Scale (PFS). The Montreal Cognitive Assessment (MoCA) was utilized to evaluate general cognitive status, covering various cognitive domains. Mood symptoms were assessed through the 21-item Depression, Anxiety, and Stress Scale (DASS-21). Lastly, the Mini-Mental State Examination (MMSE) was employed to screen for global cognitive impairment. The research highlights the reliability and effectiveness of these assessment tools in evaluating cognitive functions, emotional states, and fatigue levels in individuals with Parkinson's disease.