bluuebunny/crossref_metadata_2025 huggingface dataset:
Microbiota composition of the koala (Phascolarctos cinereus) ocular and urogenital sites, and their association with Chlamydia infection and disease
Authors: Vidgen Miranda E. , Hanger Jonathan , Timms Peter
Published: July 2017

Disease caused by Chlamydia pecorum is characterised by ocular and urogenital infections that can lead to blindness and infertility in koalas. However, koalas that are infected with C. pecorum do not always progress to disease. In other host systems, the influence of the microbiota has been implicated in either accelerating or preventing infections progressing to disease. This study investigates the contribution of koala urogenital and ocular microbiota to Chlamydia infection and disease in a free ranging koala population. Using univariate and multivariate analysis, it was found that reproductive status in females and sexual maturation in males, were defining features in the koala urogenital microbiota. Changes in the urogenital microbiota of koalas is correlated with infection by the common pathogen, C. pecorum. The correlation of microbiota composition and C. pecorum infection is suggestive of members of the microbiota being involved in the acceleration or prevention of infections progressing to disease. The analysis also suggests that multiple microbes are likely to be associated with this process of disease progression, rather than a single organism. While other Chlamydia-like organisms were also detected, they are unlikely to contribute to chlamydial disease as they are rare members of the urogenital and ocular microbiota communities.
Anti-cancerous effect of albumin coated silver nanoparticles on MDA-MB 231 human breast cancer cell line
Authors: Azizi Marzieh , Ghourchian Hedayatoallah , Yazdian Fatemeh , Bagherifam Shahla , Bekhradnia Sara , Nyström Bo
Published: July 2017

With the aim of making specific targeting of silver nanoparticles as a drug for tumor cells and developing new anticancer agents, a novel nano-composite was developed. Albumin coated silver nanoparticles (ASNPs) were synthesized, and their anti-cancerous effects were evaluated against MDA-MB 231, a human breast cancer cell line. The synthesized ASNPs were characterized by spectroscopic methods. The morphological changes of the cells were observed by inverted, florescent microscopy and also by DNA ladder pattern on gel electrophoresis; the results revealed that the cell death process occurred through the apoptosis mechanism. It was found that ASNPs with a size of 90 nm and negatively charged with a zeta-potential of about −20 mV could be specifically taken up by tumor cells. The LD50 of ASNPs against MDA-MB 231 (5 μM), was found to be 30 times higher than that for white normal blood cells (152 μM). The characteristics of the synthesized ASNPs included; intact structure of coated albumin, higher cytotoxicity against cancer cells than over normal cells, and cell death based on apoptosis and reduction of gland tumor sizes in mice. This work indicates that ASNPs could be a good candidate for chemotherapeutic drug.
Costly neighbours: Heterospecific competitive interactions increase metabolic rates in dominant species
Authors: Janča Matouš , Gvoždík Lumír
Published: July 2017

The energy costs of self-maintenance (standard metabolic rate, SMR) vary substantially among individuals within a population. Despite the importance of SMR for understanding life history strategies, ecological sources of SMR variation remain only partially understood. Stress-mediated increases in SMR are common in subordinate individuals within a population, while the direction and magnitude of the SMR shift induced by interspecific competitive interactions is largely unknown. Using laboratory experiments, we examined the influence of con- and heterospecific pairing on SMR, spontaneous activity, and somatic growth rates in the sympatrically living juvenile newts Ichthyosaura alpestris and Lissotriton vulgaris. The experimental pairing had little influence on SMR and growth rates in the smaller species, L. vulgaris. Individuals exposed to con- and heterospecific interactions were more active than individually reared newts. In the larger species, I. alpestris, heterospecific interactions induced SMR to increase beyond values of individually reared counterparts. Individuals from heterospecific pairs and larger conspecifics grew faster than did newts in other groups. The plastic shift in SMR was independent of the variation in growth rate and activity level. These results reveal a new source of individual SMR variation and potential costs of co-occurrence in ecologically similar taxa.
The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration
Authors: Munkley Jennifer , McClurg Urszula L. , Livermore Karen E. , Ehrmann Ingrid , Knight Bridget , Mccullagh Paul , Mcgrath John , Crundwell Malcolm , Harries Lorna W. , Leung Hing Y. , Mills Ian G. , Robson Craig N. , Rajan Prabhakar , Elliott David J.
Published: July 2017

Cell migration drives cell invasion and metastatic progression in prostate cancer and is a major cause of mortality and morbidity. However the mechanisms driving cell migration in prostate cancer patients are not fully understood. We previously identified the cancer-associated cell migration protein Tetraspanin 1 (TSPAN1) as a clinically relevant androgen regulated target in prostate cancer. Here we find that TSPAN1 is acutely induced by androgens, and is significantly upregulated in prostate cancer relative to both normal prostate tissue and benign prostate hyperplasia (BPH). We also show for the first time, that TSPAN1 expression in prostate cancer cells controls the expression of key proteins involved in cell migration. Stable upregulation of TSPAN1 in both DU145 and PC3 cells significantly increased cell migration and induced the expression of the mesenchymal markers SLUG and ARF6. Our data suggest TSPAN1 is an androgen-driven contributor to cell survival and motility in prostate cancer.
Circulating primitive erythroblasts establish a functional, protein 4.1R-dependent cytoskeletal network prior to enucleating
Authors: Huang Yu-Shan , Delgadillo Luis F. , Cyr Kathryn H. , Kingsley Paul D. , An Xiuli , McGrath Kathleen E. , Mohandas Narla , Conboy John G. , Waugh Richard E. , Wan Jiandi , Palis James
Published: July 2017

Hematopoietic ontogeny is characterized by distinct primitive and definitive erythroid lineages. Definitive erythroblasts mature and enucleate extravascularly and form a unique membrane skeleton, composed of spectrin, 4.1R-complex, and ankyrinR-complex components, to survive the vicissitudes of the adult circulation. However, little is known about the formation and composition of the membrane skeleton in primitive erythroblasts, which progressively mature while circulating in the embryonic bloodstream. We found that primary primitive erythroblasts express the major membrane skeleton genes present in similarly staged definitive erythroblasts, suggesting that the composition and formation of this membrane network is conserved in maturing primitive and definitive erythroblasts despite their respective intravascular and extravascular locations. Membrane deformability and stability of primitive erythroblasts, assayed by microfluidic studies and fluorescence imaged microdeformation, respectively, significantly increase prior to enucleation. These functional changes coincide with protein 4.1 R isoform switching and protein 4.1R-null primitive erythroblasts fail to establish normal membrane stability and deformability. We conclude that maturing primitive erythroblasts initially navigate the embryonic vasculature prior to establishing a deformable cytoskeleton, which is ultimately formed prior to enucleation. Formation of an erythroid-specific, protein 4.1R-dependent membrane skeleton is an important feature not only of definitive, but also of primitive, erythropoiesis in mammals.
Secretome of in vitro cultured human embryos contains extracellular vesicles that are uptaken by the maternal side
Authors: Giacomini Elisa , Vago Riccardo , Sanchez Ana Maria , Podini Paola , Zarovni Natasa , Murdica Valentina , Rizzo Roberta , Bortolotti Daria , Candiani Massimo , Viganò Paola
Published: July 2017

Communication between embryo and maternal endometrium occurs during a specific time frame in which implantation is possible. Here we demonstrate for the first time that conditioned media from non-manipulated human embryos cultured in vitro for 3 days or up to the blastocyst stage contain extracellular vesicles (EVs) with a diameter of 50 to 200 nm and bearing the traditional microvesicle and exosome marker proteins CD63, CD9 and ALIX. The embryonic origin of these EVs has been confirmed by the presence of stemness gene transcripts and their enrichment in the non-classical HLA-G protein. NANOG and POU5F1 transcripts were shown to be contained in vesicles deriving from embryos at different stages of development. In line with a higher detection rate of the HLA-G protein in blastocysts compared to cleavage stage embryos, a significantly higher amount of HLA-G was found in vesicles accumulated in spent media from day 3 to day 5 of development compared to those isolated from the earlier stage. Uptake of dye-labeled embryo-derived EVs by human primary endometrial epithelial and stromal cells was also demonstrated with a fluorescence intensity signal significantly higher for cells treated with vesicles derived from blastocysts. Based on these findings, EV exchange may be suggested as an emerging way of communication at the maternal-fetal interface.
Prospective Study on Association of Prostatic Calcifications with Clinical Symptoms and Results of Treatment in Men with type III prostatitis
Authors: Fei Xiang , Jin Wei , Hua Shengyu , Song Yan
Published: July 2017

The purpose is to investigate the clinical significance of prostatic calculi in patients with chronic prostatitis and to discuss the possible treatment.The data from 277 young males with CP/CPPS were analyzed prospectively. Symptom severity was measured using the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) and the International Prostatic Symptoms Score (IPSS). Sexual function was assessed by the International Index of Erectile Function (IIEF-5) questionnaire. After four weeks of therapy, the NIH-CPSI, IPSS, and IIEF-5 tests were repeated. The variables were compared between patients with and without prostatic calcifications using the Students t-test or chi-square test. No significant differences were found between CP/CPPS patients with and without prostatic calcifications regarding age, body mass index, prostate volume, CPSI, IPSS and IIEF-5. Men with calcifications endured symptoms significantly longer (37.9 ± 25.2 versus 19.0 ± 16.4 months, P < 0.01), and had significantly higher white blood cell counts per high power field in expressed prostatic secretions (7.7 ± 12.8 versus 3.9 ± 4.7; P < 0.01), than patients without prostatic calcifications, who responded better to medication compared with patients with prostatic calcifications. In conclusion, patients with calcifications were more likely to have category IIIA disease and they required a longer medication period.
Different Repeat Annual Influenza Vaccinations Improve the Antibody Response to Drifted Influenza Strains
Authors: Plant Ewan P. , Fredell Lucy J. , Hatcher Blake A. , Li Xing , Chiang Meng-Jung , Kosikova Martina , Xie Hang , Zoueva Olga , Cost Angelia A. , Ye Zhiping , Cooper Michael J.
Published: July 2017

Seasonal influenza vaccine formulas change almost every year yet information about how this affects the antibody repertoire of vaccine recipients is inadequate. New vaccine virus strains are selected, replacing older strains to better match the currently circulating strains. But even while the vaccine is being manufactured the circulating strains can evolve. The ideal response to a seasonal vaccine would maintain antibodies toward existing strains that might continue to circulate, and to generate cross-reactive antibodies, particularly towards conserved influenza epitopes, potentially limiting infections caused by newly evolving strains. Here we use the hemagglutination inhibition assay to analyze the antibody repertoire in subjects vaccinated two years in a row with either identical vaccine virus strains or with differing vaccine virus strains. The data indicates that changing the vaccine formulation results in an antibody repertoire that is better able to react with strains emerging after the vaccine virus strains are selected. The effect is observed for both influenza A and B strains in groups of subjects vaccinated in three different seasons. Analyses include stratification by age and sex.
Recycling and Self-Healing of Polybenzoxazines with Dynamic Sulfide Linkages
Authors: Arslan Mustafa , Kiskan Baris , Yagci Yusuf
Published: July 2017

In this work, a recycling and self-healing strategy for polybenzoxazines through both S–S bond cleavage-reformation reaction and supramolecular attractions is described. Both recyclable and self-healable polybenzoxazines can be prepared from low cost chemicals with a simple procedure in only 30 minutes. For this purpose, inverse vulcanization of poly(propylene oxide)benzoxazine (PPOB) and diallybenzoxazine (B-al) with elemental sulfur was performed at 185 °C. The obtained cross-linked polymer films exhibited thermally driven recycling ability up to 5 cycles. Moreover, the self-healing ability of a test specimen was shown. Spectral characterizations, thermal stability and fracture toughness of the films were investigated after each recycling.
Curvature controlled defect dynamics in topological active nematics
Authors: Alaimo Francesco , Köhler Christian , Voigt Axel
Published: July 2017

We study the spatiotemporal patterns that emerge when an active nematic film is topologically constraint. These topological constraints allow to control the non-equilibrium dynamics of the active system. We consider ellipsoidal shapes for which the resulting defects are 1/2 disclinations and analyze the relation between their location and dynamics and local geometric properties of the ellipsoid. We highlight two dynamic modes: a tunable periodic state that oscillates between two defect configurations on a spherical shape and a tunable rotating state for oblate spheroids. We further demonstrate the relation between defects and high Gaussian curvature and umbilical points and point out limits for a coarse-grained description of defects as self-propelled particles.
Antimicrobial effect of blue light using Porphyromonas gingivalis pigment
Authors: Yoshida Ayaka , Sasaki Haruka , Toyama Toshizo , Araki Mitsunori , Fujioka Jun , Tsukiyama Koichi , Hamada Nobushiro , Yoshino Fumihiko
Published: July 2017

The development of antibiotics cannot keep up with the speed of resistance acquired by microorganisms. Recently, the development of antimicrobial photodynamic therapy (aPDT) has been a necessary antimicrobial strategy against antibiotic resistance. Among the wide variety of bacteria found in the oral flora, Porphyromonas gingivalis (P. gingivalis) is one of the etiological agents of periodontal disease. aPDT has been studied for periodontal disease, but has risks of cytotoxicity to normal stained tissue. In this study, we performed aPDT using protoporphyrin IX (PpIX), an intracellular pigment of P. gingivalis, without an external photosensitizer. We confirmed singlet oxygen generation by PpIX in a blue-light irradiation intensity-dependent manner. We discovered that blue-light irradiation on P. gingivalis is potentially bactericidal. The sterilization mechanism seems to be oxidative DNA damage in bacterial cells. Although it is said that no resistant bacteria will emerge using aPDT, the conventional method relies on an added photosensitizer dye. PpIX in P. gingivalis is used in energy production, so aPDT applied to PpIX of P. gingivalis should limit the appearance of resistant bacteria. This approach not only has potential as an effective treatment for new periodontal diseases, but also offers potential antibacterial treatment for multiple drug resistant bacteria.
Osthole improves function of periodontitis periodontal ligament stem cells via epigenetic modification in cell sheets engineering
Authors: Sun Jin , Dong Zhiwei , Zhang Yang , He Xiaoning , Fei Dongdong , Jin Fang , Yuan Lin , Li Bei , Jin Yan
Published: July 2017

Inflammatory microenvironment causes the change of epigenetic modification in periodontal ligament stem cells derived from periodontitis tissues (P-PDLSCs), which results in defective osteogenic differentiation compared to cells from healthy tissues. It’s urgent to explore therapeutic strategies aimed at epigenetic targets associated with the regenerative ability of PDLSCs. Osthole, a small-molecule compound extracted from Chinese herbs, has been documented to promote osteogenesis and cell sheets formation of healthy PDLSCs. However, whether osthole shows same effect on P-PDLSCs and the mechanism of promotive effect is still unknown. The purpose of this study was to determine whether Osthole could restore defective osteogenic differentiation of P-PDLSCs via epigenetic modification. We demonstrated that 10−7 Mol/L of Osthole was the best concentration for osteogenic differentiation and proliferation of P-PDLSCs. Mechanistically, we also found that Osthole upregulated MOZ and MORF, histone acetylases that specifically catalyze acetylation of Histone3 lisine9 (H3K9) and Histone3 lisine14 (H3K14), which are key regulators in osteogenic differentiation of P-PDLSCs. Furthermore, Osthole treatment improved cell sheet formation and enhanced the bone formation of PDLSC sheets in animal models of periodontitis. Our study suggests that Osthole is a promising drug to cure periodontitis via regulating epigenetic modification in cell sheets engineering.
When metal clusters meet carbon cages: endohedral clusterfullerenes
Authors: Yang Shangfeng , Wei Tao , Jin Fei
Published: July 2017

Endohedral clusterfullerenes fulfil the mutual stabilization of the inner metal cluster and the outer fullerene cage.
Assessing chemotherapeutic effectiveness using a paper-based tumor model
Authors: Boyce Matthew W. , LaBonia Gabriel J. , Hummon Amanda B. , Lockett Matthew R.
Published: July 2017

A paper-based culture designed to measure differences in chemotherapeutic responsiveness between cell populations experiencing different chemical environments.
Amperometric micro pH measurements in oxygenated saliva
Authors: Chaisiwamongkhol Korbua , Batchelor-McAuley Christopher , Compton Richard G.
Published: July 2017

Amperometric micro pH measurements exploiting quinone groups on carbon fibre surfaces.
Enzyme-free, signal-amplified nucleic acid circuits for biosensing and bioimaging analysis
Authors: Chen Jiyun , Tang Lijuan , Chu Xia , Jiang Jianhui
Published: July 2017

Enzyme-free, signal-amplified nucleic acid circuits utilize programmed assembly reactions between nucleic acid substrates to transduce a chemical input into an amplified detection signal.
An enzyme-free flow cytometric bead assay for the sensitive detection of microRNAs based on click nucleic acid ligation-mediated signal amplification
Authors: Qi Yan , Qiu Liying , Fan Wenjiao , Liu Chenghui , Li Zhengping
Published: July 2017

An enzyme-free flow cytometric assay is developed for the sensitive detection of microRNAs based on click nucleic acid ligation-mediated signal amplification.
Characterization of suspected dermal fillers containing hyaluronic acid
Authors: Vanhee Celine , Desmedt Bart , Baudewyns Sébastien , Kamugisha Angélique , Vanhamme Mélissa , Bothy Jean-Luc , Kovackova Sona , Courselle Patricia , Deconinck Eric
Published: July 2017

Hyaluronic acid (HA) has important applications in the field of orthopedics, ophthalmology and cosmetics.
Probing for corticotropin-releasing hormone (CRH) in human blood for doping control purposes using immunoaffinity purification and LC-HRMS/MS
Authors: Knoop A. , Thomas A. , Bidlingmaier M. , Delahaut P. , Schänzer W. , Thevis M.
Published: July 2017

Corticotropin-releasing hormone (CRH), a peptide hormone whose secretion leads to adrenal cortisol release, is classified as prohibited substance by the World Anti-Doping Agency (WADA).
A supramolecular miktoarm star polymer based on porphyrin metal complexation in water
Authors: Hou Zhanyao , Dehaen Wim , Lyskawa Joël , Woisel Patrice , Hoogenboom Richard
Published: July 2017

A novel strategy is reported for preparing a supramolecular miktostar polymer based on complexation of a metalloporphyrin based four-arm star polymer and a pyridine functionalized polymer.
Electrochemical synthesis of phthalides via anodic activation of aromatic carboxylic acids
Authors: Hayrapetyan Davit , Shkepu Viacheslav , Seilkhanov Olzhas T. , Zhanabil Zhaisan , Lam Kevin
Published: July 2017

A new electrochemical methodology allows to easily generate aroyloxy radicals from their corresponding aromatic carboxylic acids.
Contorted polycyclic aromatic hydrocarbons with cove regions and zig-zag edges
Authors: Chen Yulan , Marszalek Tomasz , Fritz Torsten , Baumgarten Martin , Wagner Manfred , Pisula Wojciech , Chen Long , Müllen Klaus
Published: July 2017

Three tetrapyrene-fused benzocoronenes were synthesized by a “bottom-up” approach, which offers a facile access to extended polycyclic aromatic hydrocarbons with cove regions and zig-zag edges.
Extremely low catalyst loading for electroless deposition on a non-conductive surface by a treatment for reduced graphene oxide
Authors: Zhan Jing , Tan Desmond C. L. , Prakitritanon Swaek , Lin Ming , Sato Hirotaka
Published: July 2017

A reduced graphene oxide (rGO) layer added over the substrate surface drastically enhances Pd catalytic activity for electroless deposition (no densely-formed Pd catalyst is needed anymore).
Thiol-reactive (co)polymer scaffolds comprising organic arsenical acrylamides
Authors: Footman Charlotte , de Jongh Patrick A. J. M. , Tanaka Joji , Peltier Raoul , Kempe Kristian , Davis Thomas P. , Wilson Paul
Published: July 2017

Well-defined polymeric arsenicals are synthesised for the first time and exploited as responsive and reactive polymer scaffolds.
Development and photocatalytic mechanism of monolayer Bi2MoO6 nanosheets for the selective oxidation of benzylic alcohols
Authors: Jing Kaiqiang , Xiong Jinhua , Qin Na , Song Yujie , Li Liuyi , Yu Yan , Liang Shijing , Wu Ling
Published: July 2017

Monolayer Bi2MoO6 nanosheets were synthesized using a CTAB-assisted method, and exhibited greatly improved photocatalytic activity for the selective oxidation of benzylic alcohols under visible light irradiation.
A non-enzyme cascade amplification strategy for colorimetric assay of disease biomarkers
Authors: Li Jiuxing , Gao Zhuangqiang , Ye Haihang , Wan Shulin , Pierce Meghan , Tang Dianping , Xia Xiaohu
Published: July 2017

A non-enzyme cascade amplification strategy for colorimetric assay of disease biomarkers with substantially enhanced detection sensitivity has been developed.
Synthesis of carbonylated heteroaromatic compounds via visible-light-driven intramolecular decarboxylative cyclization of o-alkynylated carboxylic acids
Authors: Gao Fei , Wang Jiu-Tao , Liu Lin-Lin , Ma Na , Yang Chao , Gao Yuan , Xia Wujiong
Published: July 2017

An efficient strategy for the easy access to carbonylated heteroaromatic compounds has been developedviaa visible-light-promoted intramolecular decarboxylative cyclization reaction ofo-alkynylated carboxylic acids.
Synthesis and incorporation of an advanced lipid peroxidation end-product building block into collagen mimetic peptides
Authors: Kavianinia Iman , Yang Sung-Hyun , Kaur Harveen , Harris Paul W. R. , Dobson Renwick C. J. , Fairbanks Antony J. , Brimble Margaret A.
Published: July 2017

Advanced lipid peroxidation end-products (ALEs) accumulate with ageing and oxidative stress-related diseases.
Pumping and probing vibrational modulated coupled electronic coherence in HCN using short UV fs laser pulses: a 2D quantum nuclear dynamical study
Authors: van den Wildenberg S. , Mignolet B. , Levine R. D. , Remacle F.
Published: July 2017

Probing electronic coherences between 1A′′ and 1A′ in HCN induced by photoexcitation using a femtosecond UV pulse.
How side chains affect conformation and electrical properties of poly(acrylic acid) in solution?
Authors: Zhou Xinlu , Zhao Kongshuang
Published: July 2017

The side chains effects on effective charges or ionization properties of polyelectrolyte play important roles in their chains conformation, counterions distribution and fluctuation.
A comparative study of the influence of N,N′-dialkyl vs. N,N′-diaryl-based electron donor ancillary ligands on photocurrent and photovoltage in dye-sensitized solar cells (DSSCs)
Authors: Ashraf Saba , Yildirim Erol , Akhtar Javeed , Siddiqi Humaira M. , El-Shafei Ahmed
Published: July 2017

In this study, we report the synthesis of a novel heteroleptic Ru(ii)-sensitizer, denoted as SD-1; moreover, its photophysical, electrochemical, and photovoltaic performances were compared with those of N719 and K77-7.
Trimethylsilyl hedgehogs – a novel class of super-efficient hydrocarbon surfactants
Authors: Czajka Adam , Hill Christopher , Peach Jocelyn , Pegg Jonathan C. , Grillo Isabelle , Guittard Frédéric , Rogers Sarah E. , Sagisaka Masanobu , Eastoe Julian
Published: July 2017

Presented here are the results for a novel class of hydrocarbon surfactants, termed trimethylsilyl hedgehogs (TMS-hedgehogs), due to the presence of silicon in the tails.
Membrane interactions and antimicrobial effects of layered double hydroxide nanoparticles
Authors: Malekkhaiat Häffner S. , Nyström L. , Nordström R. , Xu Z. P. , Davoudi M. , Schmidtchen A. , Malmsten M.
Published: July 2017

Membrane interactions are critical for the successful use of inorganic nanoparticles as antimicrobial agents and as carriers of, or co-actives with, antimicrobial peptides (AMPs).
Exploring the chemical kinetics of partially oxidized intermediates by combining experiments, theory, and kinetic modeling
Authors: Hoyermann Karlheinz , Mauß Fabian , Olzmann Matthias , Welz Oliver , Zeuch Thomas
Published: July 2017

Correlation between aerosol yields and the decomposition of oxidized intermediates during gas phase ozonolysis at different pressures.
Porphyrin aggregates decorated MWCNT film for solar light harvesting: influence of J- and H-aggregation on the charge recombination resistance, photocatalysis, and photoinduced charge transfer kinetics
Authors: Devaramani Samrat , Shinger Mahgoub Ibrahim , Ma Xiaofang , Yao Meng , Zhang Shouting , Qin Dongdong , Lu Xiaoquan
Published: July 2017

Effect of J- and H-aggregation on the photophysical and photochemical properties.
On the capacitance of narrow nanotubes
Authors: Schmickler Wolfgang , Henderson Douglas
Published: July 2017

By combining DFT, electrostatics and grand-canonical Monte Carlo, we have studied the filling of narrow nanotubes with ions as a function of an applied potential.
The Langmuir–Hinshelwood approach for kinetic evaluation of cucurbit[7]uril-capped gold nanoparticles in the reduction of the antimicrobial nitrofurantoin
Authors: Blanco E. , Atienzar P. , Hernández P. , Quintana C.
Published: July 2017

Adsorption and surface kinetic constants of nitrofurantoin are calculated and compared with those of another nitro compound for the first time.
Surface-supported metal–organic framework thin films: fabrication methods, applications, and challenges
Authors: Liu Jinxuan , Wöll Christof
Published: July 2017

Surface-supported metal–organic framework thin films are receiving increasing attention as a novel form of nanotechnology, which hold great promise for photovoltaics, electronic devices, CO2 reduction, energy storage, water splitting and membranes.
Reversible trans ⇌ cis photoisomerizations of [Re(CO)3(ph2phen)(stpyCN)]+ towards molecular machines
Authors: Zanoni Kassio P. S. , Murakami Iha Neyde Y.
Published: July 2017

The fac-[Re(CO)3(ph2phen)(stpyCN)]+ complex is capable of switching through extended trans- and contracted cis-configurations upon irradiation under proper energies.
Calix[4]arene-fused phospholes
Authors: Elaieb Fethi , Sémeril David , Matt Dominique , Pfeffer Michel , Bouit Pierre-Antoine , Hissler Muriel , Gourlaouen Christophe , Harrowfield Jack
Published: July 2017

A calix[4]arene-based biarylphosphine has been synthesised and catalytically converted into two diastereomeric, calixarene-fused phospholes.
On the structures of the rare-earth metal germanides from the series REAl1−xGe3(RE = Nd, Sm, Gd, Tb, Dy, Ho; 0.6 < x < 0.9). A tale of vacancies at the Al sites and the concomitant structural modulations
Authors: Zhang Jiliang , Liu Yanyan , Shek Chan Hung , Wang Yingmin , Bobev Svilen
Published: July 2017

This paper discusses the germanides with the general formula REAl1−xGe3(RE = Nd, Sm, Gd–Ho), whose average structure is a defect-variant of the orthorhombic SmNiGe3.
Effect of low-purity Fenton reagents on toxicity of textile dyeing effluent to Daphnia magna
Authors: Na Joorim , Yoo Jisu , Nam Gwiwoong , Jung Jinho
Published: July 2017

Zinc derived from low-purity Fenton reagents induced unintended toxicity of textile dyeing effluent towardDaphnia magna.
The effect of selected food phytochemicals on breast cancer metastasis based on in vivo capture of circulating tumor cells
Authors: Wu Chuanchen , Liu Zhaochen , Zhang Zhen , Jiang Yuehua , Zhang Hongyan
Published: July 2017

The number of CTCs revealed dietary factor effects on cancer metastasis using a newin vivoCTC detection method.
β-Amino acid derived gemini surfactants from diformylfuran (DFF) with particularly low critical micelle concentration (CMC)
Authors: Girka Quentin , Hausser Nicolas , Estrine Boris , Hoffmann Norbert , Le Bras Jean , Marinković Siniša , Muzart Jacques
Published: July 2017

Starting from diformylfuran (DFF) obtained from biomass, a new family of gemini surfactants has been synthesized.
Rapid real-time recirculating PCR using localized surface plasmon resonance (LSPR) and piezo-electric pumping
Authors: Haber J. M. , Gascoyne P. R. C. , Sokolov K.
Published: July 2017

The paper describes a novel on-chip microfluidic system for rapid highly sensitive and label-free multiplex detection of DNA molecules with specific focus on pathogen detection.
Liter-scale production of uniform gas bubbles via parallelization of flow-focusing generators
Authors: Jeong Heon-Ho , Yadavali Sagar , Issadore David , Lee Daeyeon
Published: July 2017

A parallelized microfluidic device is used to generate highly monodisperse gas bubbles at a production rate of ∼1 L h−1.
Four monomeric copper(ii) complexes of non-steroidal anti-inflammatory drug Ibuprofen and N-donor ligands: syntheses, characterization, crystal structures and cytotoxicity studies
Authors: Kumar Santosh , Garg Shipra , Sharma Raj Pal , Venugopalan Paloth , Tenti Lorenzo , Ferretti Valeria , Nivelle Laetitia , Tarpin Michel , Guillon Emmanuel
Published: July 2017

The cytotoxic effects of four new Ibuprofen–Cu(ii) complexes were tested finding significant cytotoxicity on human melanoma cell line HT-144.
Aqua coordination to attenuate the luminescence properties of europium(iii)–phosphine oxide porous coordination polymers
Authors: Katagiri Kosuke , Matsuo Naoya , Kawahata Masatoshi , Masu Hyuma , Yamaguchi Kentaro
Published: July 2017

Europium(iii)–phosphine oxide porous coordination polymers (Eu–PCPs) constructed from Eu(OTf)3and tris(4-(4′-carboxylphenyl)phenyl)phosphine oxide as ligands are reported.
Formation of three-dimensionally ordered macroporous TiO2@nanosheet SnS2 heterojunctions for exceptional visible-light driven photocatalytic activity
Authors: Yan Xiaoqing , Ye Ke , Zhang Tianxi , Xue Chao , Zhang Dan , Ma Chuansheng , Wei Jinjia , Yang Guidong
Published: July 2017

We demonstrate that a 3DOM TiO2@nanosheet SnS2 heterojunction photocatalyst has been successfully synthesized via a hydrothermal method, which showed a higher photocatalytic activity for wastewater purification.
Coordination self-assembly of platinum–bisphosphonate polymer–metal complex nanoparticles for cisplatin delivery and effective cancer therapy
Authors: Huang Yanjuan , He Yuanfeng , Huang Ziyuan , Jiang Yali , Chu Weijing , Sun Xiaoqi , Huang Liangfeng , Zhao Chunshun
Published: July 2017

The constructed nanoparticles showed reduced systemic toxicity of cisplatin (CDDP) without compromising its in vivo antitumor activity.
A redox-controlled electrolyte for plasmonic enhanced dye-sensitized solar cells
Authors: Fu Yuqiao , Ng Siu-pang , Qiu Guangyu , Hung Tak-fu , Wu Chi-man Lawrence , Lee Chun-sing
Published: July 2017

A redox-controlled electrolyte (RCE) containing iodoaurate intermediates was fabricated to compensate for the corrosion problem in DSSCs.
Thermoreversible cross-linking of ethylene/propylene copolymer rubbers
Authors: Wang Aihui , Niu Hui , He Zongke , Li Yang
Published: July 2017

A functional olefin comonomer containing furan group was designed and implemented in ethylene/propylene copolymerization catalyzed by a traditional Ziegler–Natta catalyst; thus, controllable design of EP rubber with thermoreversible cross-linking capability was realized in a facile way, making the recycle of synthetic rubber more feasible.
Photoredox catalytic intramolecular imine C–H bond functionalization using ligand free Cu(ii) salts
Authors: Ren Xuhong , Wang Qiyang , Yu Wenjia , Zhan Xiaoyu , Yao Yishan , Qin Bingjie , Dong Mingxin , He Xinhua
Published: July 2017

Simple and inexpensive: The complexes of copper(ii) chelated with an N,O-bidentate directing group were found to be photoinitiators, and thereby could induce an imine C–H bond functionalization to obtain the intramolecularly cyclized product via a free radical mechanism.
One-pot synthesis of cubic PtPdCu nanocages with enhanced electrocatalytic activity for reduction of H2O2
Authors: Tian Liangliang , Chen Yanling , Wu Shenping , Cai Yanhua , Liu Hongdong , Zhang Jin , Yang Cong , He Gege , Xiao Wei , Li Lu , Lin Li , Cheng Yue
Published: July 2017

Cubic PtPdCu nanocages were prepared using Cu2O as sacrificial templates and applied to detect H2O2. PtPdCu nanocages exhibit high sensitivity at a low potential of 0.05 V. The high activity is related to the hollow structure and synergistic effect.
Ionic liquids, ultra-sounds and microwaves: an effective combination for a sustainable extraction with higher yields. The cumin essential oil case
Authors: Ascrizzi R. , González-Rivera J. , Pomelli C. S. , Chiappe C. , Margari P. , Costagli F. , Longo I. , Tiné M. R. , Flamini G. , Duce C.
Published: July 2017

This paper deals with the concept of process intensification applied to the extraction of essential oil (EO).
Lattice symmetries and the topologically protected transport of colloidal particles
Authors: Loehr Johannes , de las Heras Daniel , Loenne Michael , Bugase Jonas , Jarosz Adam , Urbaniak Maciej , Stobiecki Feliks , Tomita Andreea , Huhnstock Rico , Koch Iris , Ehresmann Arno , Holzinger Dennis , Fischer Thomas M.
Published: July 2017

The topologically protected transport of colloidal particles on top of periodic magnetic patterns is studied experimentally, theoretically, and with computer simulations.
Unexpected ultrafast and high adsorption capacity of oxygen vacancy-rich WOx/C nanowire networks for aqueous Pb2+ and methylene blue removal
Authors: Zhang Shouwei , Yang Hongcen , Huang Huiyan , Gao Huihui , Wang Xiangxue , Cao Ruya , Li Jiaxing , Xu Xijin , Wang Xiangke
Published: July 2017

Oxygen vacancy-rich WOx/C nanowire networks are fabricated by a one-pot and high yield solvothermal method, exhibiting ultrafast and high adsorption capacities.
Self-repairing silicone coatings for marine anti-biofouling
Authors: Liu Chao , Ma Chunfeng , Xie Qingyi , Zhang Guangzhao
Published: July 2017

Self-repairing silicone coatings with controlled release of organic antifoulants have excellent antifouling/fouling release performance even under static conditions.
Click chemistry stereolithography for soft robots that self-heal
Authors: Wallin T. J. , Pikul J. H. , Bodkhe S. , Peele B. N. , Mac Murray B. C. , Therriault D. , McEnerney B. W. , Dillon R. P. , Giannelis E. P. , Shepherd R. F.
Published: July 2017

Although soft robotics promises a new generation of robust, versatile machines capable of complex functions and seamless integration with biology, the fabrication of such soft, three dimensional (3D) hierarchical structures remains a significant challenge.
Thermoelectric performance enhancement of Cu2S by Se doping leading to a simultaneous power factor increase and thermal conductivity reduction
Authors: Yao Yao , Zhang Bo-Ping , Pei Jun , Liu Yao-Chun , Li Jing-Feng
Published: July 2017

A series of single-phased Cu2S1−xSex bulks were prepared by using mechanical alloying (MA) combined with spark plasma sintering (SPS). Our results suggest that the TE properties of Cu2S can be greatly enhanced by simultaneously increasing PF and decreasing κ via doping a sole Se element.
The combined effects of silicon dioxide nanoparticles and cold air exposure on the metabolism and inflammatory responses in white adipocytes
Authors: Zhang Yongqiang , Li Xi , Lin Yangsheng , Zhang Li , Guo Zhan , Zhao Dandan , Yang Danfeng
Published: July 2017

The potential hazard of nanoparticles (NPs) from air pollution has attracted widespread attention.
Effects of microRNA-211 on proliferation and apoptosis of lens epithelial cells by targeting SIRT1 gene in diabetic cataract mice
Authors: Zeng Kun , Feng Qi-Gao , Lin Bao-Tao , Ma Da-Hui , Liu Chun-Min
Published: July 2017

Our study aimed at exploring the effects of miR-211 on the proliferation and apoptosis of lens epithelial cells in diabetic cataract mice by targetting NAD+-dependent histone deacetylase sirtulin 1 (SIRT1). Healthy male mice were assigned into normal and diabetic cataract groups. Blood glucose, lens turbidity, and apoptosis were measured. Lens epithelial cells were classified into the normal, blank, negative control (NC), miR-211 mimics, miR-211 inhibitors, siRNA-SIRT1, and miR-211 inhibitors + siRNA-SIRT1 groups. MiR-211, Bcl-2, Bax, p53, and SIRT1 expressions of each group were detected. Cell proliferation, cycle and apoptosis were tested by MTT assay and flow cytometry. MiR-211 can specifically bind to SIRT1 according to the luciferase system. SIRT1 protein concentration was strongly positive in normal mice and weakly positive in diabetic cataract mice. Apoptosis index of diabetic cataract mice was higher than the normal mice. Compared with normal mice, the expressions of miR-211, Bax, and p53 increased in diabetic cataract mice, while the Bcl-2 and SIRT1 expressions decreased. In comparison with the blank and NC groups, the expressions of miR-211, Bax, and p53 increased, while Bcl-2 and SIRT1 expressions decreased, and the proliferation decreased and apoptosis rate increased in the miR-211 mimics and siRNA-SIRT1 groups; the results were contradicting for the miR-211 inhibitor group. MiR-211 could promote apoptosis and inhibit proliferation of lens epithelial cells in diabetic cataract mice by targetting SIRT1.
Judgments of Emotion in Clear and Conversational Speech by Young Adults With Normal Hearing and Older Adults With Hearing Impairment
Authors: Morgan Shae D. , Ferguson Sarah Hargus
Published: July 2017

Purpose

In this study, we investigated the emotion perceived by young listeners with normal hearing (YNH listeners) and older adults with hearing impairment (OHI listeners) when listening to speech produced conversationally or in a clear speaking style.

Method

The first experiment included 18 YNH listeners, and the second included 10 additional YNH listeners along with 20 OHI listeners. Participants heard sentences spoken conversationally and clearly. Participants selected the emotion they heard in the talker's voice using a 6-alternative, forced-choice paradigm.

Results

Clear speech was judged as sounding angry and disgusted more often and happy, fearful, sad, and neutral less often than conversational speech. Talkers whose clear speech was judged to be particularly clear were also judged as sounding angry more often and fearful less often than other talkers. OHI listeners reported hearing anger less often than YNH listeners; however, they still judged clear speech as angry more often than conversational speech.

Conclusions

Speech spoken clearly may sound angry more often than speech spoken conversationally. Although perceived emotion varied between YNH and OHI listeners, judgments of anger were higher for clear speech than conversational speech for both listener groups.

Supplemental Materials

https://doi.org/10.23641/asha.5170717
Gaussian process regression‐based modelling of lithium‐ion battery temperature‐dependent open‐circuit‐voltage
Authors: Huang C. , Wang L.
Published: July 2017

Open‐circuit‐voltage (OCV) plays a significant role in state‐of‐charge (SOC) estimation for lithium‐ion batteries. The slight difference in OCV at various temperatures can result in a large deviation of SOC estimation. In this Letter, a novel model based on Gaussian process regression is proposed to describe the sophisticated relationship among the OCV, SOC, and temperature. To validate the effectiveness of the proposed model, a comprehensive comparison with widely considered benchmarking OCV models is conducted. Experiment results demonstrate the proposed model can provide the most accurate prediction of OCV compared with benchmarking models.
Analysis of trap‐assisted tunnelling in asymmetrical underlap 3D‐cylindrical GAA‐TFET based on hetero‐spacer engineering for improved device reliability
Authors: Beohar Ankur , Yadav Nandakishor , Vishvakarma Santosh Kumar
Published: July 2017

A unique design for an asymmetrical underlap (AU) cylindrical‐gate‐all‐around (GAA)‐n‐ tunnel field effect transistor (TFET) based on hetero‐spacer engineering with trap‐assisted tunnelling (TAT) for reliability concern is proposed and validated. Here, DC and analogue performances such as ION, IOFF, SS, ION/IOFF,Cgs, and Cgd have been investigated, while included TAT model and compared the examined device with AU GAA‐TFET based on homo‐spacer (HS) dielectric. On the basis of observation, the proposed device increases ON current as high as 2.1 × 10−6 A/µm, which corresponds to 1024 times improvement in ION/IOFF when compared with device based on HS. It also suppresses ambipolar behaviour with fast switching ON–OFF transition due to low leakage current (IOFF). These performances are mainly produced due to AU and low‐k spacer dielectric which is replaced by high‐k dielectric over source side spacer of the device, whereas drain side spacer is placed with high‐k material along with increase in series resistance across drain–channel junction caused by drain underlap. Low‐k spacer reduces the fringing field, and the depletion does not form at the source–gate edge, hence high source–channel tunnelling junction.
Direct C–H Functionalization of Heteroarenes via Redox-Neutral Radical Process: A Facile Route to C–C Bonds Formation
Authors: Gao Pin , Gu Yu-Rui , Duan Xin-Hua
Published: July 2017

Aromatic heterocycles are an important class of compounds found in a wide range of natural products, pharmaceutically active molecules and organic materials. Recently, the direct radical functionalization of heteroaromatic C–H bonds has become an efficient and attractive method to access substituted heteroarenes. Especially, redox-neutral radical reactions have attracted much attention of chemists due to their potential advantages such as mild conditions, free of external oxidants, and good functional group tolerance. So far, a series of redox-neutral radical reactions have been developed. In this review, we mainly focus on the recent advance in direct redox-neutral radical C–H functionalization of heteroarenes. Herein, the direct C–H arylation, C–H alkylation, and C–H fluoroalkylation of heteroarenes are represented respectively, providing practical routes to C–C bond formation.

1 Introduction

2 C–H Arylation of Heteroarenes with Aryl Radicals

3 C–H Alkylation of Heteroarenes with Alkyl Radicals

4 C–H Fluoroalkylation of Heteroarenes with Fluorine-Containing Carbon Radicals

5 Concluding Remarks
Hydrogen-Bond-Promoted Friedel–Crafts Reaction of Secondary Propargylic Fluorides: Preparation of 1-Alkyl-1-aryl-2-alkynes
Authors: Hamel Jean-Denys , Beaudoin Meggan , Cloutier Mélissa , Paquin Jean-François
Published: July 2017

We report that aromatic propargylation is achievable with secondary propargylic fluorides, thus affording 1-alkyl-1-aryl-2-alkynes. In the present case, hydrogen bonding is responsible for the activation of the C–F bond. A large excess of arene nucleophile is shown to be necessary to achieve good yields.
Translational Research in Europe for the Assessment and Treatment for Neuromuscular Disorders (TREAT-NMD)
Authors: Leary Rebecca , Oyewole Anne , Bushby Katharine , Aartsma-Rus Annemieke
Published: July 2017

Translational research in Europe for the assessment and treatment of neuromuscular disorders (TREAT-NMD) is a global network of world-class experts within the neuromuscular community whose mission is to support all stages of therapy development and improve the health and quality of life of people around the world with neuromuscular disorders (NMD). Since 2007, TREAT-NMD has played a central role in bringing together the right experts, patients, advocacy organizations, scientists, healthcare professionals, and pharmaceutical companies. By uniting these experts within the neuromuscular community, TREAT-NMD has supported preclinical research in animal and cell models that has raised the potential for clinical trials. TREAT-NMD has successfully developed several key resources, including cell and animal standard operating protocols (preclinical research), global patient registries, ethical framework and care guidelines, and family guides, to help develop and extend translation research in the field, thereby making the field ready for clinical trials. This review aims to highlight key achievements of the network, which spans a decade and the successful partnership with our stakeholders who have enabled the field to identify and address challenges to therapeutic development and standard of care for patients. This review will also outline future perspectives.
Importance of Computed Tomography in Determining Displacement in Scaphoid Fractures
Authors: Gilley Emily , Puri Sameer , Hearns Krystle , Weiland Andrew , Carlson Michelle
Published: July 2017

Background Displaced scaphoid fractures have a relatively high rate of nonunion. Detection of displacement is vital in limiting the risk of nonunion when treating scaphoid fractures.

Questions/Purpose We evaluated the ability to diagnose displacement on radiographs and computed tomography (CT), hypothesizing that displacement is underestimated in assessing scaphoid fracture by radiograph compared with CT.

Materials and Methods Thirty-five preoperative radiographs and CT scans of acute scaphoid fractures were evaluated by two blinded observers. Displacement and angular deformity were measured, and the fracture was judged as displaced or nondisplaced. Scapholunate, radiolunate, and intrascaphoid angles were measured. Radiograph and CT measurements between nondisplaced and displaced fractures were compared. Intraobserver reliability was measured.

Results  Reader 1 identified 12 fractures as nondisplaced on radiograph, but displaced on CT (34%). Reader 2 identified 9 fractures as nondisplaced on radiograph, but displaced on CT (26%). For displaced fractures, the mean intrascaphoid angle was over three times greater when measured on CT than on radiograph (56 vs. 16 degrees). Scapholunate angle >65 degrees and radiolunate angle >16 degrees were significantly associated with displacement on CT. Interobserver reliability for diagnosing displacement was perfect on CT but less reliable on radiograph.

Conclusion Scaphoid fracture displacement on CT was identified in 26 to 34% of fractures that were nondisplaced on radiograph, confirming that radiographic evaluation alone underestimates displacement. These results underscore the importance of CT scan in determining displacement and angular deformity when evaluating scaphoid fractures, as it may alter the decision on treatment and surgical approach to the fracture. We recommend considering CT scan to evaluate all scaphoid fractures.

Level of Evidence Level III.