bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigating Combined Extreme Weather Effects on Solar Module Through
Hardware and Simulink Performance Evaluation
Authors: Botros Amir
Published: January 2025

Worldwide adoption of photovoltaic (PV) cells, which use the photovoltaic effect
to convert solar energy into electricity, has led to their emergence as a
significant source of electricity production. As the number of PV installations
continues to grow, understanding the impact of environmental factors on solar
module performance becomes paramount.

Factors such as intermittency, cloud cover, shading, and nighttime unavailability
significantly affect the efficiency and longevity of solar modules. However,
there is a shortage of research connecting extreme weather conditions to overall
module performance, hindering informed implementation decisions.

This study addresses the need for continuous monitoring of solar systems under
various extreme conditions to evaluate their initial performance and optimize
energy output. In order to achieve this, we conducted a hardware experiment
where we tested solar cell performance under varying conditions; simultaneously,
a MATLAB Simulink model was built and tested, and the results from hardware and
software were compared. Both hardware and simulation experiments showed
effective results that helped us to draw significant conclusions.
Assessing Experiential Learning in a K-12 Afterschool Makerspace
Authors: Dzbenski Stacy L.
Published: January 2025

This study investigated the efficacy of the Beyond Rubrics Toolkit (BRT) as an
embedded assessment instrument within makerspaces. Conducted as a pilot study at
two Boys & Girls Club sites during afterschool programming, the research
aimed to address the following research questions: (1) What skills are Youth
Development Professionals teaching and assessing through makerspace programming?
(2) How is learning currently assessed in the BGCS makerspaces? (3) What is the
Youth Development Professional's perception of the Beyond Rubrics toolkit as a
method to assess learning in the makerspace? (4) How would the Youth Development
Professionals characterize the student learning being assessed via the BRT? (5)
What parts of the toolkit did Youth Development Professionals find the most
useful for assessing skills taught during makerspace activities? Data collection
methods encompassed pre- and post-participant interviews, participant journals,
observational field notes, and BRT evidence collection templates. The findings
revealed challenges in seamlessly integrating the BRT evidence collection tools
into maker activities, with an overall perception that they were regarded as an
add-on rather than an integral part of the maker activity. Despite the
challenges encountered, findings suggested that increased support and training
with the BRT evidence collection tools, could enhance documentation of club
member’s understanding and use of the Maker Elements, therefore enhancing
assessment within the makerspaces. The study also underscores the importance of
developing assessment instruments tailored to informal learning environments
like makerspaces.
Factors Influencing Military Instructor Technology Self-Efficacy
Authors: Frank Gina D.
Published: January 2025

Technological self-efficacy is considered the dominant determinant of the
intention to use technology to achieve learning outcomes. Researchers in the
K-12 environment have utilized self-efficacy theory, and the factors influencing
it, to aid teachers in integrating technology into their classrooms, yet similar
research has not been conducted on military instructors. This sequential,
explanatory mixed methods study sought to identify specific factors affecting
military instructors’ levels of technology self-efficacy. The study was
conducted on military instructors at a base in the southern United States and
used the Computer Technology Integration Survey and semi-structured interview
questions to find answers to three research questions: What are the technology
self-efficacy levels of military instructors? What factors affect military
instructors’ levels of technology self-efficacy? How do the themes identified in
the interviews help to explain the military instructors’ levels of technology
self-efficacy as identified through the survey? A total of 60 instructors
completed the survey, and twelve instructors participated in the semi-structured
interviews, resulting in three themes: philosophy, barriers, and confidence. The
results aligned with research regarding self-efficacy levels in Bandura’s Social
Cognitive Theory. The implications of the findings include possibilities for
aligning other research regarding technology self-efficacy in K-12 teachers to
further research on military instructors. The results of the study should aid in
the restructuring of professional development opportunities to allow military
instructors the opportunity to learn about technology integration.
Inland Water’s Challenges in Ungauged International Basins
Authors: Modaresi Rad Arash
Published: January 2025

Inland waters face unprecedented pressures from climatic and anthropogenic
stresses, causing their recession and desiccation globally. Climate change is
increasingly blamed for such environmental degradation, but in many regions,
direct anthropogenic pressures compound, and sometimes supersede, climatic
factors. This study examined a human-environmental system – the terminal Hamun
Lakes on the Iran-Afghanistan border – that embodies amplified challenges of
inland waters. Satellite and climatic data from 1984-2019 were fused, which
documented that the Hamun Lakes lost 89% of their surface area between 1999 and
2001 (3,809 km2 versus 410 km2), coincident with a
basin-wide, multi-year meteorological drought. The lakes continued to shrink
afterwards and desiccated in 2012, despite the above-average precipitation in
the upstream basin. Rapid growth in irrigated agricultural lands occurred in
upstream Afghanistan in the recent decade, consuming water that otherwise would
have fed the Hamun Lakes. Compounding upstream anthropogenic stressors, Iran
began storing flood water that would have otherwise drained to the lakes, for
urban and agricultural consumption in 2009. Results from a deep Learning model
of Hamun Lakes’ dynamics indicate that the average lakes’ surface area from
2010-2019 would have been 2.5 times larger without increasing
anthropogenic stresses across the basin. The Hamun Lakes’ desiccation had major
socio-environmental consequences, including loss of livelihood, out-migration,
dust-storms, and loss of important species in the region.
Cyanide Abundance of Highly Aqueously Altered CM Chondrites
Authors: Reichow Rachel A.
Published: January 2025

Asteroids, and the meteorites that come from them, retained the composition of
the early Solar System and can give us insight to the processes that lead to the
origin of life. The current NASA mission, OSIRIS-REx, has returned asteroid
samples from the near-Earth asteroid Bennu. This asteroid is thought to be
similar in composition to highly aqueously altered meteorites including CM1 and
CM1/2 meteorites. Cyanide is thought to be an important molecule for prebiotic
chemistry. Simple cyanide salts would have been the most accessible form of
cyanide for reactions to occur; however, they may have recombined to form
different metal-cyanide complexes most likely during the aqueous alteration
stage(s). Understanding more about both the acid-releasable cyanide abundance
and simple salt cyanide abundance of meteorites and asteroids will give insight
to speciation of cyanide in these samples. This information will help in
understanding cyanide’s role in prebiotic chemistry.

Only one highly aqueously altered meteorite sample, and no asteroid samples, have
been analyzed for acid-releasable cyanide abundance previously. In this work, I
determined acid-releasable cyanide abundances for three highly aqueously altered
meteorites and simple salt cyanide abundances for four highly aqueously altered
meteorites using capillary-flow liquid chromatography high-resolution mass
spectrometry. The most altered meteorite analyzed, a CM1, had the lowest
abundance of acid-releasable cyanide present. The other two meteorites analyzed,
both CM1/2s, had very similar cyanide abundances compared to one another and
have a higher acid-releasable cyanide abundance than the CM1. However, there was
only one meteorite that had a simple salt cyanide concentration above my
detection limit. This concentration corresponded to less than 1% of the
acid-releasable cyanide abundance for that meteorite. If Bennu is truly similar
in composition to highly aqueously altered CM meteorites we expect to see
acid-releasable cyanide present with very little of it being due to simple
cyanide salts.
Method for real-time estimation of phase-shift angle and instantaneous frequency of quasi-harmonic signals
Authors:   Volgograd State University, Nikitin A.V. , Stankevich D.A. ,   Volgograd State University
Published: January 2025

In this paper, a method for estimating the phase shift angle between two quasi-harmonic signals over a small observation interval is proposed and investigated. The developed method allows us to study the dynamics of phase angle and instantaneous frequency in real time. Conditions under which the phase angle estimation is stable in the presence of amplitude and frequency modulation are formulated. Analytical expressions for estimation errors depending on signal parameters and normal noise level are obtained. The proposed method involves a small number of computing operations and can be used in autonomous systems, where computational resources are usually limited.
Comparative study of the efficiency of noise-proof algorithms in improving the contrast of speckle interferograms registered by the time-average method
Authors:   Samara National Research University, Ivchenko A.V.
Published: January 2025

A noise-proof algorithm for post-processing of video files recorded without isolation from vibration in the optical scheme of a digital speckle interferometer with a continuous laser and a diffuse-scattering element placed in front of the object is proposed. The results of the proposed algorithm are compared with the results of the known method for processing of a video stream in real time which is based on the sequential determination of residual images with their subsequent accumulation. The possibility of the contrast improvement by 19 – 48% compared to the basic method for the resulting speckle interferograms obtained by post-processing is shown. The developed algorithm was verified during a study of natural vibration modes of the vibrating blade of a gas turbine engine.
Effect of losses on optical properties of chiral metamembranes
Authors:   Lomonosov Moscow State University, Valenko N.V. , Dmitrieva O.A. ,   Lomonosov Moscow State University,   Prokhorov General Physics Institute, RAS, Tikhodeev S.G. ,   Lomonosov Moscow State University,   Prokhorov General Physics Institute, RAS
Published: January 2025

An optical response (reflection, transmission, and absorption spectra) of a photonic crystal layer with a square lattice of chiral holes with rotation axis C2 to circularly polarized light is theoretically investigated. The geometrical parameters of the structure are selected to achieve the maximum possible circular dichroism response under the condition of complete absence of optical losses in the system. It is shown that the account of losses in thin near-surface layers of the structure, for example, due to scattering on surface roughness or absorption due to metallization of near-surface layers, leads to rapid degradation of the degree of chirality of the optical response, increasing the absorption value. Calculations are carried out for a chiral photonic crystal layer made of diamond for a wavelength range of λ=10–12 um (wave number, 830 – 1000 cm–1).
Legal regulation of free psychological care: analysis and development prospects
Authors: Sidorova A. V. , Makusheva S. V.
Published: January 2025

In modern society great importance is paid to its psychological climate as a combination of the psychological state of individuals. His condition has an impact on economic, political, social and many other aspects of the life of society and the state. Therefore, the formation of a favorable psychological climate is one of the main tasks of the state. Of particular importance for its formation is the degree of accessibility of psychological services for the population. It was the analysis of problematic aspects in this area that was the purpose of this study. For its implementation, the following have been diagnosed: the state of legal regulation of psychological assistance in the Russian Federation; the psychological climate of Russian society and its transforming factors; forms of providing psychological services free of charge; the subject composition of persons providing psychological assistance. As a result, the author’s proposals on editing the draft law «On the provision of psychological assistance to the population in the Russian Federation», proposals for the formation of a new form of providing free psychological assistance to the population – a psychological clinic are formulated.
Maksillofasiyal Travmaların Epidemiyolojisi ve Tedavi Sonuçları: 9 Yıllık Retrospektif Çalışma
Authors: Boynuyoğun Etkin , Aygün Cebrail , Koçer Uğur
Published: January 2025

AMAÇ
Maksillofasiyal travmaların epidemiyolojik özellikleri, oluş mekanizmaları, travmanın lokalizasyonu, tedavi yöntemi ve komplikasyonları ortaya konarak, bu yaralanmaların gerek önlenmesi, gerek etkili tedavisi için klinik ve araştırma önceliklerinin belirlenmesine katkı sunulması, bireylere yönelik tedavinin kalitesinin değerlendirilmesi ve geliştirilmesine yardımcı olması amaçlanmaktadır.
GEREÇ VE YÖNTEM
Kliniğimize Ocak 2015-Ocak 2024 tarihleri arasında maksillofasiyal travma nedeniye başvuran hastalar retrospektif olarak dahil edildi. Hastaların yaşı, cinsiyeti, ek hastalıkları, travma etyolojisi, kırıkların lokalizasyonu, tedavi yöntemleri ve ameliyat sonrası komplikasyonları kaydedildi. Kırıkların tanısı anamnez ve fizik muayene sonrası, 3 boyutlu ince kesitli bilgisayarlı tomografi incelemeleri ile konuldu ve anatomik lokalizasyonuna göre sınıflandırıldı.
BULGULAR
Bu retrospektif çalışmada toplam 392 hastada meydana gelen 538 maksillofasiyal fraktür dahil edilmiştir. Bu hastaların 319’u erkek, 73’ü kadındır. Yaşları 1 ile 96 arasında sıralanmış olup, ortalama yaş 36,9 olarak bulunmuştur. Oluş mekanizmasına göre gruplandırıldığında, 169 hastada darp ile en sık sebep olarak görülürken, fraktür lokalizasyonuna göre sınıflandırıldığında, 106 hasta ile nazal kemik, maksillofasiyal bölgede en sık görülen kırık lokalizasyonu olarak bulunmuştur.
TARTIŞMA
Maksillofasiyal travmalar daha çok üretken yaşlarda meydana gelmesi nedeniyle, ciddi iş gücü kaybına neden olmaktadır. Ayrıca bu hastalar uzun dönem takiplerinde, kemik deformiteleri, görme sorunları, koku almada değişiklik, çiğneme ve nefes almada zorluk gibi yaralanmaya bağlı geç dönem sorunlar yaşayabilmektedir. Maksillofasiyal travmaların tedavisinin amacı, fonksiyon ve estetiğin tam olarak geri kazandırılmasıdır. Bu amaç doğrultusunda birçok tedavi modalitesi uygulanabilmekle birlikte, kullanılacak olan yöntem, kırığın türüne ve yerine, hasta özelliklerine ve cerrahın deneyimine ve tercihine göre değişebilmektedir.
SONUÇ
Her hastanın ve kırığın kendine özgü özellikleri olmakla birlikte, tedavi sürecinde hasta ve eşlik eden travmaları ayrı ayrı değerlendirilmelidir. Bu değerlendirme sonucunda, hastaya ve yaralanmasına uygun tedavi planı oluşturulmalıdır. Bu çalışma, maksillofasiyal yaralanma önleme stratejilerinin geliştirilmesi ve ameliyat sonrası komplikasyon geliştirme riski taşıyan hastaların belirlenmesi açısından ışık tutmaktadır.
INOVASI LKPD DIGITAL PADA MATERI SISTEM PERNAPASAN UNTUK PESERTA DIDIK KELAS XI SMA
Authors: Maharani Anggun Permata , Sari Tika Mayang
Published: January 2025

Penelitian ini bertujuan untuk memperbaiki pemahaman peserta didik terhadap materi sistem pernapasan dengan cara menyusun dan menguji LKPD digital yang dikembangkan pada peserta didik kelas XI SMAN 5 Metro. Penelitian ini menggunakan metode research and development (R&D) model ADDIE (analysis, design, development, implementation, and evaluation) sampai pada tahap development dengan batasan pada validitas dan uji coba terbatas LKPD. Hasil penelitian menunjukan bahwa LKPD yang dikembangkan sangat menarik dengan nilai prestase sebesar 80% (ahli materi), 80% (ahli media), 90% (guru), dan 80% (peserta didik).Kata kunci: LPKD Digital, Pengembangan, Sistem Pernapasan.   This research aims to improve students' understanding of respiratory system material by compiling and testing digital LKPD developed for class XI students at SMAN 5 Metro. This research uses the research and development (R&D) method of the ADDIE model (analysis, design, development, implementation, and evaluation) up to the development stage with limitations on validity and limited testing of the LKPD. The research results showed that the LKPD developed was very interesting with achievement scores of 80% (material experts), 80% (media experts), 90% (teachers), and 80% (students).Keyword: Digital LPKD, Development, Respiratory System.
VALIDITY AND PRACTICALITY OF WASAKA-BASED ETHNO-EDU MODULE IN BIOLOGY LEARNING
Authors: Ita Ita
Published: January 2025

Learning in the General Biology course requires relevant and contextual teaching materials to make it easier for lecturers and students to carry out the knowledge sharing process during lectures. One type of teaching material is a module. The module developed is the WASAKA-based Ethno-Edu Module. Next, to describe the quality of the module being developed, this research was carried out. This research, which aims to describe the validity and practicality of the WASAKA-based Ethno-Edu Module, was carried out using a method which is part of a series of research into the develop-ment of Educational Design Research (EDR) through expert review, one to one evaluation, small group evaluation and field test. The expert test was carried out by 7 validators whose assessment re-sults were calculated based on the Aiken formula. Individual tests, small group tests and field tests were carried out on students taking General Biology courses on the concept of Biodiversity. The re-search results obtained data on the content validity and linguistic validity of the WASAKA-based Ethno-Edu Module according to the Aiken formula ranging from 0.80-0.90 for each item. The valid-ity results of the module presentation ranged from 0.80-1.00 for each item. Student assessment of the practicality of the module was 4.29 in the individual test, 4.41 in the small group test and 4.28 in the field test. Thus, it can be concluded that the Ethno-Edu Module is classified as valid for use as a companion module in General Biology learning and is very practical for students to use.
PENGEMBANGAN BAHAN AJAR MODUL PEMBELAJARAN IPA BERBASIS STEM-PBL DENGAN QR CODE UNTUK MENINGKATKAN LITERASI SAINS PENCEMARAN LINGKUNGAN
Authors: Winarko Dewi Mulyati Darajatun , Abdullah Abdullah , Syahmani Syahmani , Fahmi Fahmi
Published: January 2025

Penelitian ini memiliki tujuan untuk menghasilkan bahan ajar berbasis STEM dengan QR Code yang layak dalam meningkatkan kemampuan literasi sains. Hasil penelitian ditinjau berdasarkan uji validitas, kepraktisan dan keefektifan pada modul pembelajaran IPA berbasis STEM dengan fitur QR Code yang digunakan oleh peserta didik. Metode penelitian yang digunakan adalah metode ADDIE yang terdiri dari lima tahap yaitu 1) Analisis (analyze), 2) Perancangan (design), 3) Pengembangan (development), 4) Implementasi (implementation) dan 5) Evaluasi (evaluation). Penelitian ini dilaksanakan dua uji coba kelas terdiri dari uji coba kelas terbatas yaitu kelas VII C dan uji coba kelas luas terdiri dari kelas VII A dan VII B di SMP Negeri 35 Banjarmasin. Hasil penelitian menunjukkan bahwa modul pembelajaran IPA berbasis STEM dengan fitur QR Code pada materi Pencemaran Lingkungan dinyatakan sangat valid. Modul pembelajaran IPA berbasis STEM dengan QR Code dinyatakan sangat praktis berdasarkan angket respon dari peserta didik. Modul pembelajaran IPA berbasis STEM dengan QR Code dinyatakan efektif dalam meningkatkan kemampuan literasi sains berdasarkan hasil rata-rata n-gain dengan kategori sedang pada kelas terbatas dan kategori tinggi pada kelas luas.
Platelet reactivity clinical and biochemical markers when taking acetylsalicylic acid as part of dual antiplatelet therapy in the myocardial infarction subacute period
Authors: Pronko T. P. , Snezhitskiy V. A. , Kapytski A. V.
Published: January 2025

Aim. To study markers that determine residual platelet reactivity in the subacute period of myocardial infarction (MI) during the administration of acetylsalicylic acid (ASA) as part of dual antiplatelet therapy.

Material and methods. 405 patients with MI (79.5% men and 20.5% women, average age 58.0 years) were divided into groups based on aggregometry results. Group 1 — 11 patients with low residual platelet reactivity, group 2 — 236 patients with optimal platelet reactivity, group 3 — 158 patients with high residual platelet reactivity (HRPR). All studies were performed on days 12-14 after MI: aggregometry on a Multiplate aggregometer (Germany) with several aggregation inducers, a blood test and a study of platelet indices, determination of endothelin-1, von Willebrand factor, sP-selectin and soluble CD40 ligand levels.

Results. Parameters influencing the ASPItest value according to univariate linear regression analysis: body mass index (β=0.53, 95% CI: 0.11-0.96; p=0.013); waist circumference (β=0.31, 95% CI: 0.14-0.49; p=0.0004); erythrocyte sedimentation rate (β=0.27, 95% CI: 0.12-0.42; p=0.0004); white blood cells count (β=1.47, 95% CI: 0.51-2.42; p=0.0027); platelets count (β=0.042, 95% CI: 0.019-0.064; p=0.00025); thrombocrit (β=36.8, 95% CI: 14.6-59.1; p=0.0012); mean platelet volume (β=1.94, 95% CI: 0.06-3.84; p=0.043); platelet distribution width (β=1.36, 95% CI: 0.22-2.51; p=0.02); creatinine (β=0.11, 95% CI: 0.011-0.21; p=0.03); C-reactive protein (β=0.18, 95% CI: 0.05-0.32; p=0.007); TRAP-test (β=0.18, 95% CI: 0.11-0.24; p=0.000001); fibrinogen (β=2.6, 95% CI: 1.17-4.02; p=0.0004). The binary logistic regression model to calculate the probability of developing HRPR to ASA included the following factors: platelet count, percentage of large platelet volume (PLCR), fibrinogen, endothelin-1 and von Willebrand factor. With a probability cutoff p₀=0.5412 for this model: sensitivity — 81.08%, specificity — 73.21%, classification accuracy — 76.34%, area under the ROC curve — 0.79 (CI: 0.696 - 0.883).

Conclusion. There are 2.7% of patients with an excessive response to ASA and 39.0% with an insufficient response to ASA on days 12-14 of MI. Clinical and biochemical markers of HRPR to ASA in the subacute period of MI are the number of platelets, PLCR, fibrinogen, endothelin-1 and von Willebrand factor.
Dehydroepiandrosterone and cognitive impairment and impact in cardiovascular mortality among men and women 55 years and older
Authors: Shalnova S. A. , Imaeva N. A. , Imaeva A. E. , Kutsenko V. A. , Balanova Yu. A. , Kapustina A. V. , Drapkina O. M.
Published: January 2025

Aim. To evaluate possible associations between low dehydroepiandrosterone sulfate (DHEAS) levels and cognitive impairment and their impact in cardiovascular mortality among the population 55 years and older.

Material and methods. The present study was carried out as part of the prospective cohort survey "Stress, aging and health" in Russia. 1876 men and women aged 55 years and older were examined. Cognitive function was assessed at baseline and after 3 years using the Mini- Mental State Examination scale; a decrease in cognitive function corresponded to a sum of scores less than 24 out of 30 points. DHEAS levels were assessed in serum samples. All participants were ranked according to quintiles of DHEAS levels (>2.61 μmol, 2.34-2.61 μmol/L, 1.60-2.33 μmol/L, 1.05-1.59 μmol/L, <1.05 μmol/L). Mortality was estimated from the permanent death registry using standard methods. During the follow-up period (median 12 years), 315 deaths from CVD were registered.

Results. A total of 1876 participants aged 55 years and older (48% men and 52% women) were included in the study. The frequency of cognitive function, both baseline and after three years in men was almost independent of the DHEAS level, while in women, low levels of cognitive function were predominant in the first quintile of DHEAS. With decreasing DHEAS levels, cognitive function decreased significantly in women (1 quintile vs. 5 quintiles of DHEAS), but no such associations were found in men. In a population of men 55 years and older, both cognitive impairment (OR: 2.08; 95% CI 1.49 to 2.92) and low DHEAS levels (OR: 1.60; 95% CI 1.05 to 2.44) were significantly associated with cardiovascular mortality. Similar results were obtained in the cohort of women — the risk of cardiovascular mortality was increased in the presence of cognitive impairment by 2.3-fold (p<0.05), low DHEAS by 1.6-fold (p<0.05), respectively. The simultaneous presence of these disorders was significantly associated with CVD mortality, but only in women.

Conclusion. Based on the results of the present study, an association between baseline DHEAS levels and baseline cognitive impairment was found, but only in a female population. A prospective follow-up assessment of cognitive function failed to support the hypothesis that low DHEAS levels may predict greater decline in cognitive function. However, a significant cumulative contribution of cognitive impairment combined with low DHEAS concentration to cardiovascular mortality was observed at 12-year follow-up, but only in women.
Propuesta de ruta turística con enfoque participativo en la Concesión para Conservación Cordillera de Vaquero del Biocorredor de Cordillera Vaquero-Yakukawasanapa-Sacharuna, región San Martín
Authors:   , Llacma Condo Abahan , Torres Palomino Patricia Del Carmen
Published: January 2025

Las concesiones para conservación buscan desarrollar proyectos y propuestas relacionados con la conservación y la protección de la diversidad biológica. Tal es el caso de la Concesión para conservación Cordillera de Vaquero (CCCV), la cual forma parte del biocorredor Cordillera Vaquero-Yakukawasanapa-Sacharuna, en la región San Martín, y se encuentra gestionada por la asociación de Montaraces y Técnicos Unidos por la Biodiversidad de la Amazonía (MONTUBIA). La presente investigación buscó desarrollar una propuesta de turismo con enfoque participativo de actores locales de la Concesión para Conservación Cordillera de Vaquero, por tanto, se identificó el perfil y preferencias del potencial turista. De igual manera, se identificaron y clasificaron los actores vinculados con la CCCV y, por último, se desarrolló una ficha de inventario turístico de dicha concesión. El principal resultado de esta investigación es la puesta de valor de la CCCV por medio de una propuesta piloto de ruta ecoturística con enfoque participativo.
Evaluación ultrasonografica del cuerpo lúteo de alpacas con remoción del embrión alrededor del momento de reconocimiento maternal de la preñez
Authors:   , Yañez Gil Ariadna
Published: January 2025

La alpaca (Vicugna pacos) constituye una de las fuentes de ingresos económicos de las comunidades altoandinas del Perú, a través de la comercialización de su carne y fibra. La conservación y producción de esta especie se ve afectada por diferentes factores fisiológicos, como la baja natalidad y la mortalidad embrionaria. Debido a esto, existe una necesidad de aumentar los conocimientos sobre la fisiología reproductiva de la alpaca para entender las estructuras involucradas en este proceso, como lo es el cuerpo lúteo (CL), siendo esta la estructura responsable para el mantenimiento de la preñez. Por lo tanto, este trabajo de investigación tuvo como objetivo identificar las principales características ultrasonográficas del cuerpo lúteo (CL) en hembras con y sin la presencia del embrión alrededor del momento del reconocimiento maternal de la preñez en alpacas. Para este propósito, se utilizaron 12 alpacas hembra, las cuales fueron monitoreadas diariamente mediante el uso de ultrasonografía transrectal hasta encontrar folículos ≥ 7mm de diámetro en los ovarios. Posteriormente, se procedió a someterlas a empadre, tratadas con 2 ml GnRH el mismo día y clasificadas aleatoriamente en 2 grupos de 6 animales cada uno: 1) CL con embrión (n=6); y 2) CL sin embrión (n=6), donde al día 9 post cópula, el embrión fue removido del cuerno uterino mediante la técnica no quirúrgica. La remoción del embrión se realizó para prevenir la secreción del factor del reconocimiento maternal de la preñez y evitar la señal que libera prostaglandina F2 alfa. En ambos grupos se realizó ecografía transrectal al día 2 para determinar la ovulación. Además, se evaluó de manera interdiaria a partir del día 5 hasta el día 13 para evaluar el desarrollo y calidad del cuerpo lúteo...
Análisis bibliométrico de la producción científica sobre el Síndrome de Guillain – Barré
Authors:   , Bustamante Vise Tatiana Nicole , Meneses Ventura Karina Emilia , Meneses Ventura Guillermo Marcelo
Published: January 2025

Antecedentes: El síndrome de Guillain-Barré (SGB) es un trastorno neurológico inflamatorio que causa parálisis aguda. La enfermedad ha cobrado relevancia en años recientes, especialmente con la asociación de casos a patógenos como el COVID-19. Por ello es importante seguir investigando y buscando nuevos tratamientos. Métodos: Estudio bibliométrico utilizando los documentos publicados hasta 2022 en las bases de datos Scopus y Web of Science. La estrategia de búsqueda fue realizada mediante búsqueda avanzada, se realizó la búsqueda en términos MeSH y DeCS. Se realizó el análisis de resultados y gráficos a través de página web de Scopus y en VosViewer 1.6.20. Resultados: En Scopus y Web of Science se obtuvieron un total de 6628 y 2836 documentos, respectivamente. Se observó un aumento en la producción científica en los últimos tres años de este estudio (2020-2022) a comparación de los anteriores. Estados Unidos fue el país con la mayor cantidad de publicaciones en ambas bases de datos. Se observan similares redes de colaboración en Scopus y Web of Science. Conclusiones: La producción científica sobre el SGB se ha mantenido estable con un incremento notorio en los últimos tres años analizados. El país con mayor producción de documentos publicados fue Estados Unidos.
Burnout parental, perfeccionismo y autocompasión en una muestra de padres y madres de Lima Metropolitana
Authors:   , Buitron Huillca Elizabeth
Published: January 2025

El objetivo de la presente investigación fue examinar la relación entre el burnout parental, el perfeccionismo y la autocompasión en padres y madres de Lima Metropolitana. Participaron 513 padres peruanos (Medad = 38.65 años, DE = 8.49). Mediante la técnica de modelamiento de ecuaciones estructurales se evaluó dos modelos, uno con dimensionalidad positiva de autocompasión y otro con su dimensionalidad negativa. Los resultados mostraron efectos directos significativos del perfeccionismo sobre el agotamiento parental (β = 0.82; p < 0.001), y un efecto de la autocompasión (con dimensionalidad positiva) sobre el agotamiento parental, (β = - 0.06; p < 0.01). Para el segundo modelo, los resultados fueron similares, se halló un efecto directo del perfeccionismo sobre el burnout parental (β = 0.83; p < 0.001) y un efecto directo de la autocompasión (con dimensionalidad negativa) sobre el burnout parental (β = 0.07; p < 0.01). No se encontró efectos indirectos
Language proficiency, information accessibility, and healthcare service use: a qualitative case study of Nepali migrants in Finland
Authors: Khanal Shrwan Kumar
Published: January 2025

Background
Access to healthcare is a fundamental right, yet many migrants face barriers that prevent them from accessing timely and quality healthcare services. In Finland, there is limited research on the healthcare access and quality experienced by minority groups, such as Nepali migrants. This study examines how language proficiency and access to information affect the use of healthcare services and health outcomes within the Nepali migrant community.
Methods
This qualitative study employed semi-structured interviews with 27 working age Nepali migrants in Finland, selected through purposive sampling. The interviews explored participants’ experiences with accessing healthcare, focusing on challenges related to language barriers and the accessibility of healthcare-related information. The data were analysed thematically to identify patterns in healthcare utilisation.
Results
Participants faced significant challenges in accessing reliable healthcare information, often depending on informal networks that offered inconsistent details. Their limited proficiency in local languages made it difficult to understand healthcare processes, communicate effectively with providers, and navigate available services. Additionally, the scarcity of professional interpreters and privacy concerns related to using community-based interpreters led to suboptimal healthcare experiences. These findings suggest that such barriers may contribute to poor healthcare services and undermine healthcare rights, while also increasing perceived discrimination and the risk of exploitation among migrants.
Conclusions
Migrants in destination countries often face barriers to equitable healthcare services due to limited information accessibility and a lack of support for local languages. To address these challenges, it is crucial to provide accessible healthcare information, offer language training opportunities, and ensure the availability of professional interpreting services. Additionally, future research on migrants' health should focus on less-studied migrant groups to highlight their unique experiences.
Boundary overlap in the open XXZ spin chain
Authors: Abetian Charbel , Kitanine Nikolai , Terras Véronique
Published: January 2025

In this paper we compute the overlaps of the ground states for the open spin chains after a change of one of the boundary magnetic fields. It can be considered as the first step toward the study of the boundary quench problem: behaviour of an open spin chain after an abrupt change of one boundary magnetic field.
The blue homeland (Mavi Vatan): Turkey’s Naval Strategy in the Surrounding Seas (2020-2023).
Authors: Deccache Chiozzo Vitor
Published: January 2025

This article is situated within Geopolitics and Strategic Studies, addressing a gap in Brazilian literature on the geopolitical concept of the Blue Homeland (Mavi Vatan). This concept underpins Turkey’s naval strategy and is rooted in its strategic rivalry with Greece, especially regarding sovereignty and energy resource exploration. The objective was to define the theoretical variable “Blue Homeland,” reflecting Turkey’s perspective on its surrounding seas: the Mediterranean, Aegean, and Black Seas. This definition aimed to understand naval strategy behaviour in these maritime spaces. A Case Study methodology, supported by historical and experimental methods, was used. The findings indicate that the Blue Homeland concept, developed in 2006, was adopted by the Turkish Navy’s strategic framework by 2020. It is seen as a form of neo-Ottomanism, seeking to restore Turkey’s historic role as a major power in the Middle East under President Erdoğan. The study concludes that the strategic logic of the Blue Homeland, amid Turkey-Greece rivalry, has driven the modernization and strengthening of Turkey’s Naval Force. Ultimately, the Blue Homeland signifies complete strategic autonomy, which is crucial for the survival of the Turkish state.
Responsabilidade social na Universidade: uma análise das ações de extensão da Universidade Federal Rural do Semi-Árido
Authors:   , Almeida Sarah Raquel Carvalho de Oliveira
Published: January 2025

Este projeto tratou da Responsabilidade Social na Universidade, com foco nos projetos de
extensão como importante ferramenta da relação universidade/comunidade. O objetivo deste
trabalho foi analisar como projetos de extensão da Ufersa estabelecem a relação com a
comunidade e as demandas sociais utilizando o modelo das três dimensões de
responsabilidade social proposto por Schwartz e Carroll (2003): econômica, ética e legal. No
modelo há ainda a sobreposição dessas dimensões que resulta em sete possibilidades:
puramente econômica, puramente ética, puramente legal, econômica e ética, econômica e
legal, ética e legal e, por fim, uma sobreposição que engloba as três dimensões. Para a análise,
foram definidos como objetivos específicos: traçar o perfil das ações de extensão; identificar
quais as motivações para a implementação dessas ações de extensão; verificar quais demandas
sociais foram atendidas através dessas ações; descrever a percepção dos sujeitos das ações
sobre demandas sociais atendidas. Trata-se de uma pesquisa qualitativa, que utilizou pesquisa
de campo, com entrevistas semiestruturadas, e documentos. Foram entrevistados 21 membros
dos programas/projetos, dentre eles: coordenador de projeto, vice-coordenador, técnico e
bolsistas. Os dados documentais foram os relatórios finais das ações de extensão referentes ao
Edital n° 19/2013, edital totalmente financiado pela universidade. A análise dos resultados foi
interpretativa baseada nos objetivos específicos, nos dados das entrevistas e no modelo
proposto pelos autores para, ao final, analisar conforme objetivo geral. Os resultados
demonstraram que a ação dos projetos atendeu às áreas da educação, tecnologia e produção, e
meio ambiente, e que o principal público atendido foi de alunos das escolas públicas, ensino
fundamental e médio. E ainda que a maior parte das ações se enquadra nas dimensões ética e
legal (em sua forma passiva) e que, apesar das limitações do modelo, foi possível realizar a
análise.
Manejo da fertirrigação potássica e cálcica na cultura do tomateiro cultivadas em ambiente protegido e submetidas ao estresse salino
Authors:   , Paiva Francisco Italo Gomes
Published: January 2025

A produção e a qualidade de frutos da cultura do tomate, esta diretamente relacionada com a qualidade da água utilizada na irrigação e com o suprimento adequado de nutrientes, principalmente o potássio e o cálcio. Este trabalho foi realizado no Departamento de Ciências Ambientais e Tecnológicas da Universidade Federal Rural do Semi-Árido (UFERSA), em Mossoró, RN, tendo como o objetivo avaliar o cultivo do tomate (Lycopersicumes culentum Mill), em ambiente protegido, utilizando irrigação com águas salinas, e fertirrigação com diferentes relações potássio:cálcio. O delineamento experimental utilizado foi em blocos casualizados, em esquema fatorial 5 x 4, com quatro repetições. O experimento foi realizado em ambiente protegido utilizando substrato a base de fibra de coco. Os tratamentos foram formados pela combinação de cinco relações iônicas de potássio e cálcio (F1-K+/Ca2+=1,5:1; F2-K+/Ca2+=1,25:1; F3-K+/Ca2+=1:1; F4-K+/Ca2+=1:1,25 e F5-K+/Ca2+=1:1,5) utilizando soluções padrões para cada cultura, segundo literatura especializada, com quatro níveis de salinidade da água de irrigação (S1-0,5; S2-2,0; S3-3,5 e S4-5,0 dS m-1). A relação K+/Ca2+=1:1 correspondente a concentração desses nutrientes recomendada para a cultura em cultivo de tomateiro hidropônico. As plantas foram avaliadas quanto a variáveis de crescimento (altura, diâmetro do caule, número de folhas, área foliar, massa seca do caule, folhas, frutos e total), rendimento (número de frutos por planta, massa média de frutos e produção de frutos por planta) e qualidade de frutos (sólidos solúveis, acides total, ºBrix, Vitamina C e relação AT/SS). As relações K+/Ca2+ estudadas não mitigaram o efeito sobre as variáveis analisadas. O uso de baixas relações K+/Ca2+ potencializou o efeito da salinidade sobre as plantas.
Mendelian Randomization and Transcriptome Data Analysis Reveal Bidirectional Causal Relationships and Mechanisms Between Type 2 Diabetes and Gastric Cancer
Authors: Ma Junyang , Gao Yuan , Hou Shufu , Cui Shichang , Zhu Jiankang
Published: January 2025

Introduction:

Gastric cancer (GC) is the fifth most common cancer globally,
and the relationship between type 2 diabetes mellitus (T2DM) and cancer risk remains
controversial.

Methods:

We performed Mendelian randomization (MR) analysis using publicly available GWAS data to assess the causal relationship between T2DM and GC, validated by
heterogeneity and pleiotropy analyses. Transcriptomic data from TCGA and GEO were
analyzed to identify common differentially expressed genes (DEGs). Weighted gene co--
expression network analysis (WGCNA) was used to construct a prognostic risk model.
Drug sensitivity and immune infiltration were evaluated using GDSC and ImmuCellAI,
respectively. Additionally, gene mutation analysis was conducted using TCGA data.

Results:

The Mendelian randomization analysis revealed a causal relationship between
T2DM and GC at the genetic level. Specifically, the causal effect of T2DM on GC was
estimated with an odds ratio (OR) of 1.32 (95% CI: 1.12-1.56), while the reverse causal
effect of GC on T2DM was estimated at an OR of 0.78 (95% CI: 0.67-0.91). Sensitivity
analyses, including Cochran's Q test and the leave-one-out test, confirmed the robustness of these findings. We constructed a prognostic risk score consisting of three T2DM-related genes (CST2, PSAPL1, and C4orf48) based on transcriptome data analysis.
Patients with high-risk scores exhibited significantly worse overall survival (OS) (p <
0.05). Cox regression analysis further confirmed the independent predictive value of the
risk score for GC prognosis. Our predictive model demonstrated good performance,
with an AUC of 0.786 in the training set and 0.757 in the validation set. Gene enrichment analysis indicated that the genes shared between T2DM and GC were associated
with inflammatory response, immune response, and metabolic pathways. Tumor immune microenvironment analysis suggested that immune evasion mechanisms may play
a key role in developing GC in patients with coexisting T2DM.

Conclusion:

T2DM is associated with reduced GC risk. The risk score and model may
help guide GC prognosis and management.
Drug Repurposing: A Conduit to Unravelling Metabolic Reprogramming
for Cancer Treatment
Authors: Chaudhary Shristy , Rana Abhilash , Bhatnagar Seema
Published: January 2025

Metabolic reprogramming is a hallmark of cancer. Distinct and unusual metabolic aberrations
occur during tumor development that lead to the growth and development of tumors. Oncogenic
signaling pathways eventually converge to regulate three major metabolic pathways in tumor cells
i.e., glucose, lipid, and amino acid metabolism. Therefore, identifying and targeting the metabolic
nodes of cancer cells can be a promising intervention and therapeutic strategy for patients with malignancies.
The long road of new drug discovery for cancer therapy has necessitated relooking alternative
strategies such as drug repurposing. Advanced genomic and proteomic technologies for the
assessment of cancer-specific biological pathways have led to the discovery of new drug targets,
which provide excellent opportunities for drug repurposing. The development of effective, safe,
cheaper, and readily available anticancer agents is the need of the hour, and drug repurposing has
the potential to break the current drug shortage bottleneck. This review will accordingly cover various
metabolic pathways that are aberrant in cancer, and strategies for targeting metabolic reprogramming
by using repurposed drugs.
siRNA Knocking Down in HepG2 Cells Identifies PFKFB4 and HNF4α as Key Genes Important for Cancer Cell Survival
Authors: Imraish Amer , Alshaer Walhan , Abu-Thiab Tuqa , Enaya Fatima , Al‐Ameer Hamzeh J. , Al-Hunaiti Afnan , Abumurad Mohammad , Zihlif Malek
Published: January 2025

Introduction:

Liposomes are versatile delivery systems for encapsulating small interfering
RNAs (siRNAs) because they enhance cellular uptake and gene silencing. This study compares
the new liposome formula to commercial lipofectamine in delivering siRNAs targeting hepatic
carcinoma genes, focusing on HNF4-α and PFKFB4.

Methods:

Flow cytometry and confocal microscopy revealed efficient internalization of PE-Rhod-
B labeled lipoplexes in HepG2 cells, while cytotoxicity assays demonstrated significant reductions
in cell viability, particularly with siHNF4-α and siPFKFB4.

Results:

The newly formulated liposomes showed superior efficacy, achieving nearly 93% cytotoxicity
at 100 nM, compared to just 50% with lipofectamine at the same concentration. Furthermore,
real-time PCR confirmed that the liposome-encapsulated siHNF4-α reduced HNF4-α mRNA
expression by tenfold at 100 nM, compared to a twofold reduction with lipofectamine at 200
nM. Similarly, siPFKFB4 delivered via liposomes showed a dose-dependent 35-fold reduction in
PFKFB4 mRNA expression at 100 nM, outperforming the maximum reduction achieved by lipofectamine.
The IC50 values for all siRNA treatment groups were significantly lower when using
the liposome formula, reflecting improved delivery efficiency.

Conclusion:

These results demonstrate the potential of liposome formulations for therapeutic siRNA
delivery. The encapsulation enhances cellular uptake and gene silencing efficiency, making
the liposome formula a promising candidate for targeted gene therapy in hepatic carcinoma. Further
research should explore it’s in vivo biodistribution and potential combination therapies.
Current Status and Future Trends in Myocarditis Related to the COVID-19 Vaccines: A Visual and Bibliometric Analysis
Authors: Zhang Youao , Wang Mengjia , Wang Jieyan
Published: January 2025

Aims:

This study aims to conduct a bibliometric and visual analysis of published studies
on myocarditis and coronavirus disease 2019 (COVID-19) vaccines.

Background:

The widespread epidemic of COVID-19 has caused millions of deaths and profoundly
affected the global medical landscape. Studies on COVID-19 vaccination and related myocarditis
have also increased significantly.

Objective:

To analyze the current status and trends of myocarditis and COVID-19 vaccine research
by bibliometric and to elucidate research hotspots and frontiers.

Methods:

Based on the Web of Science Core Collection SCI-Expanded database, we utilize Excel
2019 and visualization analysis tools VOSviewer, Co-Occurrence13.2 (COOC13.2), Citespace,
HistCite, and Scimago Graphica for analysis.

Results:

Our study encompassed a total of 389 relevant articles, and we observed a consistent upward
trend in the number of publications over time, indicating the growing interest in this subject. Among
the countries and regions contributing to this body of literature, the United States emerged as the
leading publisher, with Harvard Medical School being the most prominent institution associated with
these studies. Notably, Matthew E. Oster from the United States emerged as one of the prominent
authors in this field. Hotspot research and frontier areas include myocarditis and the different types of
COVID-19 vaccines (e.g., mRNA vaccines, adenovirus vector vaccines, inactivated vaccines), the
development of new vaccines in reducing the incidence and sequelae of COVID-19 without an increased
incidence of myocarditis, and relief of vaccine hesitancy.

conclusion:

Research on myocarditis following the COVID-19 vaccine has grown rapidly. Our research results can help researchers grasp the current status of myocarditis following the COVID-19 vaccine research and find new research directions in the future.

Conclusion:

Research on myocarditis and the COVID-19 vaccines has grown rapidly. Our research
results can help researchers grasp the current status of myocarditis related to the COVID-19 vaccine
research and find new research directions in the future.