bluuebunny/crossref_metadata_2025 huggingface dataset:
Head-to-head comparison of [68Ga]Ga-FAPI-04 and [18F]-FDG PET/CT in evaluating the extent of disease in gastric adenocarcinoma
Authors: Kuten Jonathan , Levine Charles , Shamni Ofer , Pelles Sharon , Wolf Ido , Lahat Guy , Mishani Eyal , Even-Sapir Einat
Published: July 2021

Background

[18F]-Fluorodeoxyglucose (FDG) positron emission tomography–computed tomography (PET/CT) may sometimes be suboptimal for imaging gastric adenocarcinoma. The recently introduced [68Ga]Ga-FAPI-04 (FAPI) PET/CT targets tumor stroma and has shown considerable potential in evaluating the extent of disease in a variety of tumors.

Methods

We performed a head-to-head prospective comparison of FAPI and FDG PET/CT in the same group of 13 patients with gastric adenocarcinoma who presented for either initial staging (n = 10) or restaging (n = 3) of disease. Lesion detection and maximum standardized uptake value (SUVmax) were compared between the two types of radiotracers.

Results

All ten primary gastric tumors were FAPI-positive (100% detection rate), whereas only five were also FDG-positive (50%). SUVmax was not significantly different, but the tumor-to-background ratio was higher for FAPI (mean, median, and range of 4.5, 3.2, and 0.8–9.7 for FDG and 12.9, 11.9, and 2.2–23.9 for FAPI, P = 0.007). The level of detection of regional lymph node involvement was comparable. FAPI showed a superior detection rate for peritoneal carcinomatosis (100% vs. none). Two patients with widespread peritoneal carcinomatosis underwent a follow-up FAPI scan after chemotherapy: one showed partial remission and the other showed progressive disease.

Conclusions

The findings of this pilot study suggest that FAPI PET/CT outperforms FDG PET/CT in detecting both primary gastric adenocarcinoma and peritoneal carcinomatosis from gastric cancer. FAPI PET/CT also shows promise for monitoring response to treatment in patients with peritoneal carcinomatosis from gastric cancer; however, larger trials are needed to validate these preliminary findings.
Localised Radial Patterns on the Free Surface of a Ferrofluid
Authors: Hill Dan J. , Lloyd David J. B. , Turner Matthew R.
Published: July 2021

This paper investigates the existence of localised axisymmetric (radial) patterns on the surface of a ferrofluid in the presence of a uniform vertical magnetic field. We formally investigate all possible small-amplitude solutions which remain bounded close to the pattern’s centre (the core region) and decay exponentially away from the pattern’s centre (the far-field region). The results are presented for a finite-depth, infinite expanse of ferrofluid equipped with a linear magnetisation law. These patterns bifurcate at the Rosensweig instability, where the applied magnetic field strength reaches a critical threshold. Techniques for finding localised solutions to a non-autonomous PDE system are established; solutions are decomposed onto a basis which is independent of the radius, reducing the problem to an infinite set of nonlinear, non-autonomous ODEs. Using radial centre manifold theory, local manifolds of small-amplitude solutions are constructed in the core and far-field regions, respectively. Finally, using geometric blow-up coordinates, we match the core and far-field manifolds; any solution that lies on this intersection is a localised radial pattern. Three distinct classes of stationary radial solutions are found: spot A and spot B solutions, which are equipped with two different amplitude scaling laws and achieve their maximum amplitudes at the core, and ring solutions, which achieve their maximum amplitudes away from the core. These solutions correspond exactly to the classes of localised radial solutions found for the Swift–Hohenberg equation. Different values of the linear magnetisation and depth of the ferrofluid are investigated and parameter regions in which the various localised radial solutions emerge are identified. The approach taken in this paper outlines a route to rigorously establish the existence of axisymmetric localised patterns in the future.
A computational method to simulate mono- and poly-disperse two-dimensional foams flowing in obstructed channel
Authors: Lavoratti Thales Carl , Heitkam Sascha , Hampel Uwe , Lecrivain Gregory
Published: July 2021

A modified phase-field model is presented to numerically study the dynamics of flowing foam in an obstructed channel. The bubbles are described as smooth deformable fields interacting with one another through a repulsive potential. A strength of the model lies in its ability to simulate foams with wide range of gas fraction. The foam motion, composed of about hundred two-dimensional gas elements, was analyzed for gas fractions ranging from 0.4 to 0.99, that is below and beyond the jamming transition. Simulations are preformed near the quasi-static limit, indicating that the bubble rearrangement in the obstructed channel is primarily driven by the soft collisions and not by the hydrodynamics. Foam compression and relaxation upstream and downstream of the obstacle are reproduced and qualitatively match previous experimental and numerical observations. Striking dynamics, such as bubbles being squeezed by their neighbors in negative flow direction, are also revealed at intermediate gas fractions.
Accelerate postoperative management after scoliosis surgery in healthy and impaired children: intravenous opioid therapy versus epidural therapy
Authors: Dinter Katharina , Bretschneider Henriette , Zwingenberger Stefan , Disch Alexander , Osmers Anne , Vicent Oliver , Thielemann Falk , Seifert Jens , Bernstein Peter
Published: July 2021

Purpose

Postoperative pain is a major concern following scoliosis surgery. CEA (continuous epidural analgesia) is established in postoperative pain therapy as well as intravenous patient-controlled analgesia (IV-PCA). The purpose of this study was to compare the clinical outcomes of both methods.

Methods

We retrospectively studied 175 children between 8 and 18 years who were subject to posterior scoliosis correction and fusion. Two main cohorts were formed: CEA with local anesthetic and opioids, and IV-PCA with opioids. Both groups further comprised two sub-cohorts: those who were mentally and/or physically healthy (H; n = 93 vs. n = 30) and those who were impaired (I; n = 26 vs. n = 26). The outcome parameters were the demand for pain medication, parameters of mobilization, and the presence of adverse reactions.

Results

Healthy children who received CEA started mobilization 1 day earlier than children with IV-PCA (p = 0.002). First postsurgical defecation was seen earlier in all children who received CEA in both groups (H; Day 4 vs. Day 5, p = 0.011, I; Day 3 vs. Day 5, p = 0.044). Healthy children who received CEA were discharged from hospital 4 days earlier than their IV-PCA counterparts (p < 0.001). No statistically significant difference in postoperative nausea nor in vomiting was identified between groups. Transient neurological irritations were seen in 9.7% of the patients in the CEA group.

Conclusions

CEA provides appropriate pain management after scoliosis surgery, regardless of the patient’s mental status. It allows earlier postoperative defecation for all patients , as well as shorter hospitalization and an earlier mobilization for healthy patients.
A systematic review on the effect of low-dose radiation on hearing
Authors: Nayak Srikanth , Nambi Arivudai , Kumar Sathish , Hariprakash P , Yuvaraj Pradeep , Poojar Basavaraj
Published: July 2021

Numerous studies have documented the adverse effects of high-dose radiation on hearing in patients. On the other hand, radiographers are exposed to a low dose of ionizing radiation, and the effect of a low dose of radiation on hearing is quite abstruse. Therefore, the present systematic review aimed to elucidate the effect of low-dose ionizing radiation on hearing. Two authors independently carried out a comprehensive data search in three electronic databases, including PUBMED/MEDLINE, CINAHL, and SCOPUS. Eligible articles were independently assessed for quality by two authors. Cochrane Risk of Bias tool was used assess quality of the included studies. Two articles met the low-dose radiation exposure criteria given by Atomic Energy Regulatory Board (AERB) and National Council on Radiation Protection (NCRP) guidelines. Both studies observed the behavioral symptoms, pure-tone hearing sensitivity at the standard, extended high frequencies, and the middle ear functioning in low-dose radiation-exposed individuals and compared with age and gender-matched controls. One study assessed the cochlear function using transient-evoked otoacoustic emissions (TEOAE). Both studies reported that behavioral symptoms of auditory dysfunction and hearing thresholds at extended high frequencies were higher in radiation-exposed individuals than in the controls. The current systematic review concludes that the low-dose ionizing radiation may affect the hearing adversely. Nevertheless, further studies with robust research design are required to explicate the cause and effect relationship between the occupational low-dose ionizing radiation exposure and hearing.
Detection and infectivity of SARS-CoV-2 in exhumated corpses
Authors: Plenzig S. , Holz F. , Bojkova D. , Kettner M. , Cinatl J. , Verhoff M. A. , Birngruber C. G. , Ciesek S. , Rabenau H. F.
Published: July 2021

Postmortem detection of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) after the exhumation of a corpse can become important, e.g. in the case of subsequent medical malpractice allegations. To date, data on possible detection periods [e.g. by reverse transcription polymerase chain reaction (RT-PCR)] or on the potential infectivity of the virus after an exhumation are rare. In the present study, these parameters were examined in two cases with a time span of approximately 4 months between day of death and exhumation. Using SARS-CoV-2 RT-PCR on swabs of both lungs and the oropharynx detection was possible with cycle threshold (Ct) values of about 30 despite signs of beginning decay. RT-PCR testing of perioral and perinasal swabs and swabs collected from the inside of the body bag, taken to estimate the risk of infection of those involved in the exhumation, was negative. Cell culture-based infectivity testing was negative for both, lung and oropharyngeal swabs. In one case, RT-PCR testing at the day of death of an oropharyngeal swab showed almost identical Ct values as postmortem testing of an oropharyngeal swab, impressively demonstrating the stability of viral RNA in the intact corpse. However, favorable climatic conditions in the grave have to be taken into account, as it was wintertime with constant low temperatures. Nevertheless, it was possible to demonstrate successful postmortem detection of SARS-CoV-2 infection following exhumation even after months in an earth grave.
Occupational groups and its physical and mental health correlates: results from the Singapore Mental Health Study 2016
Authors: Sambasivam Rajeswari , Jeyagurunathan Anitha , Abdin Edimansyah , Shafie Saleha , Chang Sherilyn , Vaingankar Janhavi Ajit , Chong Siow Ann , Subramaniam Mythily
Published: July 2021

Purpose

The physical and mental wellbeing of an individual is impacted by the type occupation one does. This study aims to establish the prevalence of mental and physical disorders, the association of occupational groups and health-related quality of life, and the extent of work-loss and work-cut back in past 30 days among the employed in the Singapore resident population.

Methods

Data from a population-based, epidemiological survey of a representative sample of Singapore citizens and permanent residents aged 18 years and above were used. Lifetime diagnosis of select mental disorders was established using the World Health Organization’s Composite International Diagnostic Interview version 3.0 (WHO-CIDI 3.0). Data on nicotine dependence, work productivity, quality of life and socio-demographics were obtained via self-report. Ten major occupational groups based on the Singapore Standard Occupational Classification were included in the analysis.

Results

The sample comprised 4021 employed individuals who were predominantly males (54.7%) and aged 35–49 years (35.4%). ‘Service and sales workers’ (22.6%), ‘Professionals’ (17.3%) and ‘Legislators, senior officials and managers’ (16.4%) were the three largest occupational groups. Socio-demographic characteristics differed significantly (p < 0.001) across all occupational groups. Lifetime prevalence of mood disorders among the employed was 8.4% and the most prevalent physical disorder was chronic pain (18.9%). No significant differences were observed in work productivity loss across the occupational groups.

Conclusions

The disparities in the socio-demographic characteristics and prevalence of mental and physical disorders across occupational categories provide policymakers with vital information to pilot effective interventions that can improve the psychosocial and physical conditions at work.
Treatment efficacy and safety of regorafenib plus drug-eluting beads-transarterial chemoembolization versus regorafenib monotherapy in colorectal cancer liver metastasis patients who fail standard treatment regimens
Authors: Cao Fei , Zheng Jiaping , Luo Jun , Zhang Zhewei , Shao Guoliang
Published: July 2021

Objective

This study aimed to evaluate the efficacy and safety of regorafenib plus drug-eluting beads-transarterial chemoembolization (DEB-TACE) versus regorafenib monotherapy in colorectal cancer liver metastases (CRLM) patients who failed standard treatment regimens.

Methods

Totally, 76 eligible CRLM patients were analyzed, among which 42 patients received regorafenib monotherapy (as regorafenib group) and 34 patients received regorafenib plus DEB-TACE (as regorafenib plus DEB-TACE group).

Results

Objective response rate (35.3% versus 7.1%, P = 0.002) and disease control rate (76.5% versus 47.6%, P = 0.011) were both increased in regorafenib plus DEB-TACE group compared with regorafenib group; meanwhile, negative conversion rate of carcinoembryonic antigen (66.7% versus 28.6%, P = 0.008) after treatment was elevated in regorafenib plus DEB-TACE group compared with regorafenib group. Notably, progression-free survival (PFS) (median value: 7.6 versus 4.1 months, P < 0.001) and overall survival (OS) (median value: 15.7 versus 9.2 months, P < 0.001) were both higher in regorafenib plus DEB-TACE group compared with regorafenib group. Furthermore, liver function indexes (alanine transaminase, aspartate aminotransferase, and cholinesterase levels) after treatment were all similar between the two groups (all P > 0.05). In addition, the occurrences of upper abdominal distending pain (P < 0.001), nausea and vomiting (P = 0.002) and fever (P = 0.002) were higher in regorafenib plus DEB-TACE group compared with regorafenib group, while the majority of these adverse events were mild and tolerable.

Conclusions

Regorafenib plus DEB-TACE is superior to regorafenib monotherapy regarding treatment response, PFS and OS, while induces tolerable post-embolization syndrome in CRLM patients who fail standard treatment regimens.
Prognostic significance of high mobility group A2 (HMGA2) in pancreatic ductal adenocarcinoma: malignant functions of cytoplasmic HMGA2 expression
Authors: Gundlach Jan-Paul , Hauser Charlotte , Schlegel Franka Maria , Willms Anna , Halske Christine , Röder Christian , Krüger Sandra , Röcken Christoph , Becker Thomas , Kalthoff Holger , Trauzold Anna
Published: July 2021

Purpose

HMGA2 has frequently been found in benign as well as malignant tumors and a significant association between HMGA2 overexpression and poor survival in different malignancies was described. In pancreatic ductal adenocarcinoma (PDAC), nuclear HMGA2 expression is associated with tumor dedifferentiation and presence of lymph node metastasis. Nevertheless, the impact of HMGA2 occurrence in other cell compartments is unknown.

Methods

Intracellular distribution of HMGA2 was analyzed in PDAC (n = 106) and peritumoral, non-malignant ducts (n = 28) by immunohistochemistry. Findings were correlated with clinico-pathological data. Additionally, intracellular HMGA2 presence was studied by Western blotting of cytoplasmic and nuclear fractions of cultured cells.

Results

HMGA2 was found in the cytoplasm and in the nucleus of cultured cells. In human tumor tissue, HMGA2 was also frequently found in the cytoplasm and the nucleus of tumor cells, however, nuclear staining was generally stronger. Direct comparison from tumor tissue with corresponding non-neoplastic peritumoral tissue revealed significantly stronger expression in tumors (p = 0.003). Of note, the nuclear staining was significantly stronger in lymph node metastatic cell nuclei compared to primary tumor cell nuclei (p = 0.049). Interestingly, cytoplasmic staining positively correlated with lymph vessel (p = 0.004) and venous invasion (p = 0.046).

Conclusion

HMGA2 is a prognostic marker in PDAC. Firstly, we found a positive correlation for cytoplasmic HMGA2 expression with lympho-vascular invasion and, secondly, we found a significantly stronger nuclear expression of HMGA2 in cancer-positive lymph node nuclei compared to primary tumor cell nuclei. So far, the role of cytoplasmic HMGA2 is nearly unknown, however, our data lend support to the hypothesis that cytoplasmic HMGA2 expression is involved in nodal spread.
An FFT-based approach for Bloch wave analysis: application to polycrystals
Authors: Segurado Javier , Lebensohn Ricardo A.
Published: July 2021

A method based on the Fast Fourier Transform is proposed to obtain the dispersion relation of acoustic waves in heterogeneous periodic media with arbitrary microstructures. The microstructure is explicitly considered using a voxelized Representative Volume Element (RVE). The dispersion diagram is obtained solving an eigenvalue problem for Bloch waves in Fourier space. To this aim, two linear operators representing stiffness and mass are defined through the use of differential operators in Fourier space. The smallest eigenvalues are obtained using the implicitly restarted Lanczos and the subspace iteration methods, and the required inverse of the stiffness operator is done using the conjugate gradient with a preconditioner. The method is used to study the propagation of acoustic waves in elastic polycrystals, showing the strong effect of crystal anistropy and polycrystaline texture on the propagation. It is shown that the method combines the simplicity of classical Fourier series analysis with the versatility of Finite Elements to account for complex geometries proving an efficient and general approach which allows the use of large RVEs in 3D.
A TTP-incorporated scoring model for predicting mortality of solid tumor patients with bloodstream infection caused by Escherichia coli
Authors: Zhang Qing , Gao Hao-Yang , Li Ding , Bai Chang-Sen , Li Zheng , Zheng Shan , Zhang Wen-Fang , Zhou Yun-Li , Zhang Si-He
Published: July 2021

Background

Few mortality-scoring models are available for solid tumor patients who are predisposed to develop Escherichia coli–caused bloodstream infection (ECBSI). We aimed to develop a mortality-scoring model by using information from blood culture time to positivity (TTP) and other clinical variables.

Methods

A cohort of solid tumor patients who were admitted to hospital with ECBSI and received empirical antimicrobial therapy was enrolled. Survivors and non-survivors were compared to identify the risk factors of in-hospital mortality. Univariable and multivariable regression analyses were adopted to identify the mortality-associated predictors. Risk scores were assigned by weighting the regression coefficients with corresponding natural logarithm of the odds ratio for each predictor.

Results

Solid tumor patients with ECBSI were distributed in the development and validation groups, respectively. Six mortality-associated predictors were identified and included in the scoring model: acute respiratory distress (ARDS), TTP ≤ 8 h, inappropriate antibiotic therapy, blood transfusion, fever ≥ 39 °C, and metastasis. Prognostic scores were categorized into three groups that predicted mortality: low risk (< 10% mortality, 0–1 points), medium risk (10–20% mortality, 2 points), and high risk (> 20% mortality, ≥ 3 points). The TTP-incorporated scoring model showed excellent discrimination and calibration for both groups, with AUC being 0.833 vs 0.844, respectively, and no significant difference in the Hosmer–Lemeshow test (6.709, P = 0.48) and the chi-square test (6.993, P = 0.46). Youden index showed the best cutoff value of ≥ 3 with 76.11% sensitivity and 79.29% specificity. TTP-incorporated scoring model had higher AUC than no TTP-incorporated model (0.837 vs 0.817, P < 0.01).

Conclusions

Our TTP-incorporated scoring model was associated with improving capability in predicting ECBSI-related mortality. It can be a practical tool for clinicians to identify and manage bacteremic solid tumor patients with high risk of mortality.
Motivational learning biases are differentially modulated by genetic determinants of striatal and prefrontal dopamine function
Authors: Richter Anni , de Boer Lieke , Guitart-Masip Marc , Behnisch Gusalija , Seidenbecher Constanze I. , Schott Björn H.
Published: July 2021

Dopaminergic neurotransmission plays a pivotal role in appetitively motivated behavior in mammals, including humans. Notably, action and valence are not independent in motivated tasks, and it is particularly difficult for humans to learn the inhibition of an action to obtain a reward. We have previously observed that the carriers of the DRD2/ANKK1 TaqIA A1 allele, that has been associated with reduced striatal dopamine D2 receptor expression, showed a diminished learning performance when required to learn response inhibition to obtain rewards, a finding that was replicated in two independent cohorts. With our present study, we followed two aims: first, we aimed to replicate our finding on the DRD2/ANKK1 TaqIA polymorphism in a third independent cohort (N = 99) and to investigate the nature of the genetic effects more closely using trial-by-trial behavioral analysis and computational modeling in the combined dataset (N = 281). Second, we aimed to assess a potentially modulatory role of prefrontal dopamine availability, using the widely studied COMT Val108/158Met polymorphism as a proxy. We first report a replication of the above mentioned finding. Interestingly, after combining all three cohorts, exploratory analyses regarding the COMT Val108/158Met polymorphism suggest that homozygotes for the Met allele, which has been linked to higher prefrontal dopaminergic tone, show a lower learning bias. Our results corroborate the importance of genetic variability of the dopaminergic system in individual learning differences of action–valence interaction and, furthermore, suggest that motivational learning biases are differentially modulated by genetic determinants of striatal and prefrontal dopamine function.
Photobiomodulation enhances facial nerve regeneration via activation of PI3K/Akt signaling pathway–mediated antioxidant response
Authors: Li Bohan , Wang Xiao
Published: July 2021

Facial nerve dysfunction is a common clinical condition that leads to disfigurement and emotional distress in the affected individuals. This study aimed to evaluate whether photobiomodulation can enhance regeneration of crushed facial nerves and attempt to investigate the possible underlying mechanism of neuroprotective function and therapeutic target. Various parameters of photobiomodulation were assigned to the facial nerves and Schwann cells (SCs) separately during crushed injury in rats. Axonal regeneration, functional outcomes, and SC apoptosis, proliferation, and underlying mechanisms of action were evaluated by morphological, histopathological, and functional assessments, flow cytometry, western blotting, real-time PCR, and IncuCyte. The results showed that photobiomodulation improved axonal regeneration and functional recovery, and also promoted proliferation, and inhibited apoptosis of SCs, both of these were considered as the most effective parameters in 250mW group. In addition, the neuroprotective effects of photobiomodulation (500mW) were likely associated with oxidative stress–induced SC apoptosis via activation of the PI3K/Akt signaling pathway. Our results revealed that photobiomodulation significantly promoted axonal regeneration, functional recovery, and regeneration of the facial nucleus, and its mechanism was related to the up-regulation of the PI3K/Akt signaling pathway. These findings provide clear experimental evidence of photobiomodulation as an alternative therapeutic strategy for peripheral nerve damage.
Architectural model for muscle growth during maturation
Authors: Papenkort Stefan , Böl Markus , Siebert Tobias
Published: July 2021

Muscle architecture, which includes parameters like fascicle length, pennation angle, and physiological cross-sectional area, strongly influences skeletal muscles' mechanical properties. During maturation, the muscle architecture has to adapt to a growing organism. This study aimed to develop an architectural model capable of predicting the complete 3D fascicle architecture for primarily unipennate muscles of an arbitrary age, based on fascicle data for an initial age. For model development, we collected novel data on 3D muscle architecture of the rabbit (Oryctolagus cuniculus) M. plantaris of eight animals ranging in age from 29 to 106 days. Experimental results show that plantaris muscle belly length increases by 73%, whereas mean fascicle length and mean pennation angle increases by 39 and 14%, respectively. Those changes were incorporated into the model. In addition to the data collected for M. plantaris the predictions of the model were compared to existing literature data of rabbit M. soleus and M. gastrocnemius medialis. With an error of −1.0 ± 8.6% for relative differences in aponeurosis length, aponeurosis width, muscle height, and muscle mass, the model delivered good results matching interindividual differences. For future studies, the model could be utilized to generate realistic architectural data sets for simulation studies.
Examining HIV Risk and Exchange Sex Among Current and Formerly Homeless Young Adults
Authors: Madden Danielle R. , Semborski Sara , Dzubur Eldin , Redline Brian , Rhoades Harmony , Henwood Benjamin F.
Published: July 2021

This study investigated HIV risk among homeless and formerly homeless young adults by examining risky sex behaviors (e.g., condomless sex, exchange sex, and sex with multiple persons) using 90-day and daily recall methods. Data came from a sample of young adults (aged 18–27) with current (n = 101) or past (n = 109) homelessness experience in Los Angeles, California, recruited between 2017 and 2019. Baseline surveys queried demographics and sexual history. Daily retrospective surveys queried sexual events. Multiple logistic regressions were used to test the effects of demographic characteristics including homelessness history, relationship status, substance use, and sexual history on risky sex outcomes. In this sample, 26% reported never using a condom during anal or vaginal sex in the past 90 days, 5% reported testing positive for HIV, 82% had limited to no knowledge of preexposure prophylaxis, and 8% reported having had exchange sex during a 7-day measurement period, with those experiencing homelessness more likely to report. The study suggests supportive housing can reduce the occurrence of exchange sex but that HIV prevention services are still needed in homeless and housing programs to promote safe sexual practices.
Horizontal convection in a rectangular enclosure driven by a linear temperature profile
Authors: Yang Tianyong , Wang Bofu , Wu Jianzhao , Lu Zhiming , Zhou Quan
Published: July 2021

The horizontal convection in a square enclosure driven by a linear temperature profile along the bottom boundary is investigated numerically by using a finite difference method. The Prandtl number is fixed at 4.38, and the Rayleigh number Ra ranges from 107 to 1011. The convective flow is steady at a relatively low Rayleigh number, and no thermal plume is observed, whereas it transits to be unsteady when the Rayleigh number increases beyond the critical value. The scaling law for the Nusselt number Nu changes from Rossby’s scaling Nu ∼ Ra1/5 in a steady regime to Nu ∼ Ra1/4 in an unsteady regime, which agrees well with the theoretically predicted results. Accordingly, the Reynolds number Re scaling varies from Re ∼ Ra3/11 to Re ∼ Ra2/5. The investigation on the mean flows shows that the thermal and kinetic boundary layer thickness and the mean temperature in the bulk zone decrease with the increasing Ra. The intensity of fluctuating velocity increases with the increasing Ra.
Typical transient effects in a piezoelectric semiconductor nanofiber under a suddenly applied axial time-dependent force
Authors: Yang Wanli , Liang Yuxing
Published: July 2021

Based on the mechanical motion equation, Gauss’s law, and the current continuity condition, we study a few typical transient effects in a piezoelectric semiconductor (PS) fiber to realize the startup and turning-off functions of common piezotronic devices. In this study, the transient extensional vibration induced by a suddenly applied axial time-dependent force is examined in a cantilevered n-type ZnO nanofiber. Neither the magnitude of the loadings nor the doping concentration significantly affects the propagation caused by disturbance of the axial displacement. However, both of the factors play an important role in the propagation caused by disturbance of the electron concentrations. This indicates that the electromechanical coupling effect can be expected to directly determine the electronic performance of the devices. In addition, the assumption of previous simplified models which neglect the charge carriers in Gauss’s law is discussed, showing that this assumption has a little influence on the startup state when the doping concentration is smaller than 1021 m−3. This suggests that the screening effect of the carriers on the polarized electric field is much reduced in this situation, and that the state is gradually transforming into a pure piezoelectric state. Nevertheless, the carriers can provide a damping effect, which means that the previous simplified models do not sufficiently describe the turning-off state. The numerical results show that the present study has referential value with respect to the design of newly multifunctional PS devices.
Challenges and Paradoxes in Decolonising HCI: A Critical Discussion
Authors: Lazem Shaimaa , Giglitto Danilo , Nkwo Makuochi Samuel , Mthoko Hafeni , Upani Jessica , Peters Anicia
Published: July 2021

The preponderance of Western methods, practices, standards, and classifications in the manner in which new technology-related knowledge is created and globalised has led to calls for more inclusive approaches to design. A decolonisation project is concerned with how researchers might contribute to dismantling and re-envisioning existing power relations, resisting past biases, and balancing Western heavy influences in technology design by foregrounding the authentic voices of the indigenous people in the entire design process. We examine how the establishment of local Global South HCI communities (AfriCHI and ArabHCI) has led to the enactment of decolonisation practices. Specifically, we seek to uncover how decolonisation is perceived in the AfriCHI and ArabHCI communities as well as the extent to which both communities are engaged with the idea of decolonisation without necessarily using the term. We drew from the relevant literature, our own outsider/insider lived experiences, and the communities’ responses to an online anonymised survey to highlight three problematic but interrelated practical paradoxes: a terminology, an ethical, and a micro-colonisation paradox. We argue that these paradoxes expose the dilemmas faced by local non-Western researchers as they pursue decolonisation thinking. This article offers a blended perspective on the decolonisation debate in HCI, CSCW, and the practice-based CSCW scholarly communities and invites researchers to examine their research work using a decolonisation lens.
(Mere) Verbalness and Substantivity Revisited
Authors: Knoll Viktoria
Published: July 2021

Verbal disputes are often seen as closely related to a lack of substantivity. However, a systematic and comprehensive investigation of how verbalness relates to substantivity is still missing. The present paper attempts to close this gap. In addition to offering different conceptions of verbalness, the paper further develops Sider’s (Writing the Book of the World, OUP, Oxford, 2011) notion of substantivity. Ultimately, I argue for a more careful choice of terminology when it comes to assessing a dispute as “(merely) verbal” or “nonsubstantive”. While the paper shows that there is no strict logical relation between mere verbalness and nonsubstantivity construed along the lines set out by Sider, it also demonstrates that further notable notions of (mere) verbalness and substantivity are in fact closely intertwined.
Application of Big Data and Artificial Intelligence in COVID-19 Prevention, Diagnosis, Treatment and Management Decisions in China
Authors: Dong Jiancheng , Wu Huiqun , Zhou Dong , Li Kaixiang , Zhang Yuanpeng , Ji Hanzhen , Tong Zhuang , Lou Shuai , Liu Zhangsuo
Published: July 2021

COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spread rapidly and affected most of the world since its outbreak in Wuhan, China, which presents a major challenge to the emergency response mechanism for sudden public health events and epidemic prevention and control in all countries. In the face of the severe situation of epidemic prevention and control and the arduous task of social management, the tremendous power of science and technology in prevention and control has emerged. The new generation of information technology, represented by big data and artificial intelligence (AI) technology, has been widely used in the prevention, diagnosis, treatment and management of COVID-19 as an important basic support. Although the technology has developed, there are still challenges with respect to epidemic surveillance, accurate prevention and control, effective diagnosis and treatment, and timely judgement. The prevention and control of sudden infectious diseases usually depend on the control of infection sources, interruption of transmission channels and vaccine development. Big data and AI are effective technologies to identify the source of infection and have an irreplaceable role in distinguishing close contacts and suspicious populations. Advanced computational analysis is beneficial to accelerate the speed of vaccine research and development and to improve the quality of vaccines. AI provides support in automatically processing relevant data from medical images and clinical features, tests and examination findings; predicting disease progression and prognosis; and even recommending treatment plans and strategies. This paper reviews the application of big data and AI in the COVID-19 prevention, diagnosis, treatment and management decisions in China to explain how to apply big data and AI technology to address the common problems in the COVID-19 pandemic. Although the findings regarding the application of big data and AI technologies in sudden public health events lack validation of repeatability and universality, current studies in China have shown that the application of big data and AI is feasible in response to the COVID-19 pandemic. These studies concluded that the application of big data and AI technology can contribute to prevention, diagnosis, treatment and management decision making regarding sudden public health events in the future.
Environmental and economic analysis of bioethanol production from sugarcane molasses and agave juice
Authors: Parascanu Maria Magdalena , Sanchez Nestor , Sandoval-Salas Fabiola , Carreto Carlos Mendez , Soreanu Gabriela , Sanchez-Silva Luz
Published: July 2021

In this article, sugarcane molasses and agave juice were compared as potential feedstocks for producing bioethanol in Mexico in terms of their environmental impact and economic factors. Life cycle assessment (LCA) using SimaPro was carried out to calculate environmental impacts by using a cradle-to-gate approach. A preliminary economic analysis was performed to determine the economic feasibility of the studied options. Also, capital goods costs were obtained using the Aspen Plus economy package. Moreover, a sensitivity analysis was involved to compare the environmental and economic viability of producing bioethanol from sugarcane molasses and agave juice. LCA results revealed that cultivation and fermentation were the most harmful stages when producing bioethanol from sugarcane molasses and agave juice, respectively. Furthermore, when it was derived from agave juice rather than sugarcane molasses, it had more environmental benefits. This was ascribed to the lower consumption rate of fertilizers, pesticides, and emissions given off from the former. Regarding financial aspects, the preliminary analysis showed that producing bioethanol was not economically viable when grid energy alone was used. However, if power from the grid is partially replaced with renewable energy, producing bioethanol becomes economically feasible, and sugarcane molasses is the most suitable feedstock.

Graphical abstract
Characterization of black crusts developed on historic stones with diverse mineralogy under different air quality environments
Authors: Pozo-Antonio José Santiago , Cardell Carolina , Comite Valeria , Fermo Paola
Published: July 2021

Black crusts (BCs) are one of the most critical alteration forms found on stones belonging to architectural heritage. Since they could be considered as passive samplers of atmospheric pollution, it would be plausible to establish relations between the air contamination and the BCs. With this aim, we have characterized BCs collected on historic buildings from two Spanish cities (Granada and Vigo) with different polluted atmospheres, as well as formed on stone substrates of varied mineralogy and texture. Likewise, in order to assess the impact of the atmospheric pollutants on the growth of BCs, quartz fiber filters were used as surrogate substrates and placed nearby the studied buildings to collect and analyze the aerosol particulate matter (PM). To this end, an array of complementary analytical techniques was used to evaluate the mineralogy, chemical composition, and texture of the BCs and to establish the correlation with the ions, OC (organic carbon), and EC (elemental carbon) detected in the PM on the quartz fiber filters. As result, BCs developed on carbonate substrates from Granada show more complex structure than those from Vigo, which are thinner because of frequent rain episodes. In both cities, NaCl, Pb-Cl, and Ca-Cl-rich particles, Ca-phosphate particles and clusters of Ba-sulfate-rich particles were detected. However, metal-rich rounded particles were more abundant in Granada’s BCs, including soot particles. BCs from Granada were richer in carbonaceous components (OC and EC) than the Vigo’s BCs. Although in the filters PM did not show EC—mainly due to traffic—, in the BCs from both locations OC and EC were detected. Therefore, this different composition was related to the mineralogy of the stones and the higher pollution of Granada in contrast to the industrial and sea-exposed city of Vigo.
The Potato of the Future: Opportunities and Challenges in Sustainable Agri-food Systems
Authors: Devaux André , Goffart Jean-Pierre , Kromann Peter , Andrade-Piedra Jorge , Polar Vivian , Hareau Guy
Published: July 2021

In the coming decades, feeding the expanded global population nutritiously and sustainably will require substantial improvements to the global food system worldwide. The main challenge will be how to produce more food with the same or fewer resources and waste less. Food security has four dimensions: food availability, food access, food use and quality, and food stability. Among several other food sources, the potato crop is one that can help match all these constraints worldwide due to its highly diverse distribution pattern, and its current cultivation and demand, particularly in developing countries with high levels of poverty, hunger, and malnutrition. After an overview of the current situation of global hunger, food security, and agricultural growth, followed by a review of the importance of the potato in the current global food system and its role played as a food security crop, this paper analyses and discusses how potato research and innovation can contribute to sustainable agri-food systems comparing rural and industrial agri-food systems with reference to food security indicators. It concludes with a discussion about the challenges for sustainable potato cropping enhancement considering the needs to increase productivity in rural-based potato food systems that predominate in low-income countries, while promoting better resource management and optimization in industrial-based agri-food systems considering factors such as quality, diversity of products, health impacts, and climate change effects. Research and innovation options and policies that could facilitate the requirements of both rural and industrial potato-based agri-food systems are described.
Objective assessment of surgeon kinematics during simulated laparoscopic surgery: a preliminary evaluation of the effect of high body mass index models
Authors: Sers Ryan , Forrester Steph , Zecca Massimiliano , Ward Stephen , Moss Esther
Published: July 2021

Purpose

Laparoscopy is used in many surgical specialties. Subjective reports have suggested that performing laparoscopic surgery in patients with a high body mass index (BMI) is leading to increased prevalence of musculoskeletal symptoms in surgeons. The aim of this study was to objectively quantify the impact on surgeon upper body kinematics and dynamic workload when performing simulated laparoscopy at different BMI levels.

Methods

Upper body kinematics and dynamic workload of novice, intermediate and expert surgeons were calculated based on measurements from inertial measurement units positioned on upper body segments. Varying thicknesses of foam were used to simulate patient BMIs of 20, 30, 40 and 50 kg/m2 during laparoscopic training.

Results

Significant increases in the jerkiness, angular speed and cumulative displacement of the head, torso and upper arms were found within all experience groups when subject to the 40 and 50 kg/m2 models. Novice surgeons were found to have less controlled kinematics and larger dynamic workloads compared to the more experienced surgeons.

Conclusions

Our findings indicate that performing laparoscopic surgery on a high BMI model worsens upper body motion efficiency and efficacy, and increases dynamic workload, producing conditions that are more physically demanding when compared to operating on a 20 kg/m2 model. These findings also suggest that the head, torso, and upper arm segments are especially affected by high BMI models and therefore exposure to patients with high BMIs may increase the risk of musculoskeletal injury when performing laparoscopic surgery.
Harming, Rescuing and the Necessity Constraint on Defensive Force
Authors: Fabre Cécile
Published: July 2021

In The Morality of Defensive Force, Quong defends a powerful account of the grounds and conditions under which an agent may justifiably inflict serious harm on another person. In this paper, I examine Quong's account of the necessity constraint on permissible harming—the RESCUE account. I argue that RESCUE does not succeed. Section 2 describes RESCUE. Section 3 raises some worries about Quong's conceptual construal of the right to be rescued and its attendant duties. Section 4 argues that RESCUE does not deliver the verdicts that Quong wants. In those sections, I assume that the attacker is culpable for the threat he poses. Section 5 considers cases where the attacker, though responsible for the wrongful threat he poses and therefore liable to defensive force, has an epistemic justification for acting as he does and thus is not morally culpable. In his discussion of necessity, Quong does not explicitly deal with such cases. I suggest that RESCUE does not operate in the same way when attackers are mistaken as when they are morally culpable.
Impact of Surface Topography, Chemistry and Properties on the Adhesion of Sodium Alginate Coatings Electrophoretically Deposited on Titanium Biomaterials
Authors: Warcaba Maciej , Kowalski Kazimierz , Kopia Agnieszka , Moskalewicz Tomasz
Published: July 2021

In this paper, we report on the electrophoretic deposition and characterisation of pure sodium alginate coatings on titanium biomaterials, the commercially pure titanium CP-Ti1 and Ti–13Nb–13Zr titanium alloy. Various solutions differing in the distilled water to ethanol volume ratio and sodium alginate concentration were used for coating deposition. Uniform, dense and continuous coatings with a thickness up to 1 µm were deposited. The effect of surface topography and morphology, wettability and surface free energy as well as surface chemistry on the coating adhesion to the titanium biomaterials were investigated. The coatings exhibited very good adhesion to the polished and then chemically treated alloy. The adhesion mechanisms were identified. The chemical bonding and interfacial adhesion mechanisms are plausible. The coatings exhibited low surface development, dependent on the applied substrate roughness. Sodium alginate coatings on both substrates showed moderate hydrophilicity and relatively high surface free energy, on average 30 pct higher in comparison with that of the substrate materials. The obtained results will be useful for the further development of composite sodium alginate coatings for enhancing the biological performance of titanium biomaterials.
Characterization of virgin olive oils obtained from minor Tunisian varieties for their valorization
Authors: Chtourou Fatma , Valli Enrico , Ben Mansour Amir , Bendini Alessandra , Gallina Toschi Tullia , Bouaziz Mohamed
Published: July 2021

Several compositional parameters (fatty acids, tocopherols, polar phenols and volatiles) in virgin olive oils from varieties located at the center of Tunisia, namely Baldi, Chemchali, Neb Jmel, Tounsi and Besbessi from Gafsa and Chemchali and Sehli cultivated in Sidi Bouzid, were studied. To the best of our knowledge, this is the first study focusing on the chemical composition of virgin olive oils (VOO) from Sidi Bouzid. Significant differences were found between varieties from Sidi Bouzid and Gafsa in monounsaturated saturated fatty acid levels, some volatile compounds and γ-tocopherol amounts. Notably, Tounsi and Baldi VOOs showed the highest six carbon atoms alcohol contents, whereas Neb Jmel VOO revealed the highest aldehyde six carbon atoms content. Fatty acid composition, as well as tocopherol content, showed differences among different VOO. Principal component analysis and hierarchical component analysis on polar phenols, fatty acids, tocopherols and volatiles data evidenced a good discrimination among oils from the different investigated varieties.