bluuebunny/crossref_metadata_2025 huggingface dataset:
Fitting superparamagnetic and distributed Cole-Cole parameters to airborne electromagnetic data: A case history from Quebec
Authors: Macnae James
Published: September 2016

Our aim was to confirm the ability of polarizable and superparamagnetic (SPM) thin sheets in the near surface to improve the model fit of airborne electromagnetic data. Our method was to fit induced polarization (IP) effects with Cole-Cole complex conductivity and fit SPM effects with Chikazumi complex permeability. Surficial conductors were assumed to be the source of the conductivity and IP effects. In this case history from Lac Brûlé, Quebec over an anorthosite intrusion, small to large IP effects were found to be essential to fit most of the observed data. In some areas, it was also possible to separate SPM effects from IP effects in the data. Most IP effects in this unusually polarizable area were adequately fit with a distributed decay characterized with a frequency dependence of [Formula: see text], but some required a sharper response characterized by [Formula: see text]. In general, fitted IP time constants were anticorrelated with fitted frequency dependence, with short time constants fitted to the larger [Formula: see text] values and vice versa. SPM effects were detected in a small but significant fraction of the data, and appear to be spatially related to static magnetic anomalies. The SPM in this case is presumably related to fine-grained rock magnetism, rather than the more common case of weathering products.
Monitoring shale gas resources in the Cooper Basin using magnetotellurics
Authors: Rees Nigel , Carter Simon , Heinson Graham , Krieger Lars
Published: September 2016

The magnetotelluric (MT) method is introduced as a geophysical tool to monitor hydraulic fracturing of shale gas reservoirs and to help constrain how injected fluids propagate. The MT method measures the electrical resistivity of earth, which is altered by the injection of fracturing fluids. The degree to which these changes are measurable at the surface is determined by several factors, such as the conductivity and quantity of the fluid injected, the depth of the target interval, the existing pore fluid salinity, and a range of formation properties, such as porosity and permeability. From an MT monitoring survey of a shale gas hydraulic fracture in the Cooper Basin, South Australia, we have found temporal and spatial changes in MT responses above measurement error. Smooth inversions are used to compare the resistivity structure before and during hydraulic fracturing, with results showing increases in bulk conductivity of 20%–40% at a depth range coinciding with the horizontal fracture. Comparisons with microseismic data lead to the conclusion that these increases in bulk conductivity are caused by a combination of the injected fluid permeability and an increase in wider scale in situ fluid permeability.
Enrollment Trends and Disparity Among Patients With Lung Cancer in National Clinical Trials, 1990 to 2012
Authors: Pang Herbert H. , Wang Xiaofei , Stinchcombe Thomas E. , Wong Melisa L. , Cheng Perry , Ganti Apar Kishor , Sargent Daniel J. , Zhang Ying , Hu Chen , Mandrekar Sumithra J. , Redman Mary W. , Manola Judith B. , Schilsky Richard L. , Cohen Harvey J. , Bradley Jeffrey D. , Adjei Alex A. , Gandara David , Ramalingam Suresh S. , Vokes Everett E.
Published: September 2016

Purpose

Under-representation of elderly, women, and racial/ethnic minority patients with cancer in clinical trials is of national concern. The goal of this study was to characterize enrollment trends and disparities by age, sex, and race/ethnicity in lung cancer trials.

Methods

We analyzed data for 23,006 National Cancer Institute cooperative group lung cancer trial participants and 578,476 patients with lung cancer from the SEER registry from 1990 to 2012. The enrollment disparity difference (EDD) and enrollment disparity ratio (EDR) were calculated on the basis of the proportion of each subgroup in the trial population and the US lung cancer population. Annual percentage changes (APCs) in the subgroup proportions in each population were compared over time.

Results

Enrollment disparity for patients ≥ 70 years of age with non–small-cell lung cancer improved from 1990 to 2012 (test of parallelism, P = .020), with a remaining EDD of 0.22 (95% CI, 0.19 to 0.25) and EDR of 1.65 (95% CI, 1.51 to 1.82) in 2010 to 2012. No improvement was seen for elderly patients with small-cell lung cancer (SCLC), with an APC of 0.20 ( P = .714) among trial participants, despite a rising proportion of elderly patients with SCLC in the US population (APC, 0.32; P = .020). Enrollment disparity for women with lung cancer improved overall, with the gap closing by 2012 (EDD, 0.03 [95% CI, 0.00 to 0.06]; EDR, 1.07 [95% CI, 1.00 to 1.16]). Enrollment disparities persisted without significant improvement for elderly women, blacks, Asians/Pacific Islanders, and Hispanics.

Conclusion

Under-representation in lung cancer trials improved significantly from 1990 to 2012 for elderly patients with non–small-cell lung cancer and for women, but ongoing efforts to improve the enrollment of elderly patients with SCLC and minorities are needed. Our study highlights the importance of addressing enrollment disparities by demographic and disease subgroups to better target under-represented groups of patients with lung cancer.
Modified Staging Classification for Pancreatic Neuroendocrine Tumors on the Basis of the American Joint Committee on Cancer and European Neuroendocrine Tumor Society Systems
Authors: Luo Guopei , Javed Ammar , Strosberg Jonathan R. , Jin Kaizhou , Zhang Yu , Liu Chen , Xu Jin , Soares Kevin , Weiss Matthew J. , Zheng Lei , Wolfgang Christopher L. , Cives Mauro , Wong Joyce , Wang Wei , Sun Jian , Shao Chenghao , Wang Wei , Tan Huangying , Li Jie , Ni Quanxing , Shen Lin , Chen Minhu , He Jin , Chen Jie , Yu Xianjun
Published: September 2016

Purpose

The European Neuroendocrine Tumor Society (ENETS) and the American Joint Committee on Cancer (AJCC) staging classifications are two widely used systems in managing pancreatic neuroendocrine tumors. However, there is no universally accepted system.

Methods

An analysis was performed to evaluate the application of the ENETS and AJCC staging classifications using the SEER registry (N = 2,529 patients) and a multicentric series (N = 1,143 patients). A modified system was proposed based on analysis of the two existing classifications. The modified system was then validated.

Results

The proportion of patients with AJCC stage III disease was extremely low for both the SEER series (2.2%) and the multicentric series (2.1%). For the ENETS staging system, patients with stage I disease had a similar prognosis to patients with stage IIA disease, and patients with stage IIIB disease had a lower hazard ratio for death than did patients with stage IIIA disease. We modified the ENETS staging classification by maintaining the ENETS T, N, and M definitions and adopting the AJCC staging definitions. The proportion of patients with stage III disease using the modified ENETS (mENETS) system was higher than that of the AJCC system in both the SEER series (8.9% v 2.2%) and the multicentric series (11.6% v 2.1%). In addition, the hazard ratio of death for patients with stage III disease was higher than that for patients with stage IIB disease. Moreover, statistical significance and proportional distribution were observed in the mENETS staging classification.

Conclusion

An mENETS staging classification is more suitable for pancreatic neuroendocrine tumors than either the AJCC or ENETS systems and can be adopted in clinical practice.
Antitumor Activity of Pembrolizumab in Biomarker-Unselected Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Results From the Phase Ib KEYNOTE-012 Expansion Cohort
Authors: Chow Laura Q.M. , Haddad Robert , Gupta Shilpa , Mahipal Amit , Mehra Ranee , Tahara Makoto , Berger Raanan , Eder Joseph Paul , Burtness Barbara , Lee Se-Hoon , Keam Bhumsuk , Kang Hyunseok , Muro Kei , Weiss Jared , Geva Ravit , Lin Chia-Chi , Chung Hyun Cheol , Meister Amy , Dolled-Filhart Marisa , Pathiraja Kumudu , Cheng Jonathan D. , Seiwert Tanguy Y.
Published: September 2016

Purpose

Treatment with pembrolizumab, an anti–programmed death-1 antibody, at 10 mg/kg administered once every 2 weeks, displayed durable antitumor activity in programmed death-ligand 1 (PD-L1) –positive recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) in the KEYNOTE-012 trial. Results from the expansion cohort, in which patients with HNSCC, irrespective of biomarker status, received a fixed dose of pembrolizumab at a less frequent dosing schedule, are reported.

Patients and Methods

Patients with R/M HNSCC, irrespective of PD-L1 or human papillomavirus status, received pembrolizumab 200 mg intravenously once every 3 weeks. Imaging was performed every 8 weeks. Primary end points were overall response rate (ORR) per central imaging vendor (Response Evaluation Criteria in Solid Tumors v1.1) and safety. Secondary end points included progression-free survival, overall survival, and association of response and PD-L1 expression. Patients who received one or more doses of pembrolizumab were included in analyses.

Results

Of 132 patients enrolled, median age was 60 years (range, 25 to 84 years), 83% were male, and 57% received two or more lines of therapy for R/M disease. ORR was 18% (95% CI, 12 to 26) by central imaging vendor and 20% (95% CI, 13 to 28) by investigator review. Median duration of response was not reached (range, ≥ 2 to ≥ 11 months). Six-month progression-free survival and overall survival rates were 23% and 59%, respectively. By using tumor and immune cells, a statistically significant increase in ORR was observed for PD-L1–positive versus –negative patients (22% v 4%; P = .021). Treatment-related adverse events of any grade and grade ≥ 3 events occurred in 62% and 9% of patients, respectively.

Conclusion

Fixed-dose pembrolizumab 200 mg administered once every 3 weeks was well tolerated and yielded a clinically meaningful ORR with evidence of durable responses, which supports further development of this regimen in patients with advanced HNSCC.
Pneumonitis in Patients Treated With Anti–Programmed Death-1/Programmed Death Ligand 1 Therapy
Authors: Naidoo Jarushka , Wang Xuan , Woo Kaitlin M. , Iyriboz Tunc , Halpenny Darragh , Cunningham Jane , Chaft Jamie E. , Segal Neil H. , Callahan Margaret K. , Lesokhin Alexander M. , Rosenberg Jonathan , Voss Martin H. , Rudin Charles M. , Rizvi Hira , Hou Xue , Rodriguez Katherine , Albano Melanie , Gordon Ruth-Ann , Leduc Charles , Rekhtman Natasha , Harris Bianca , Menzies Alexander M. , Guminski Alexander D. , Carlino Matteo S. , Kong Benjamin Y. , Wolchok Jedd D. , Postow Michael A. , Long Georgina V. , Hellmann Matthew D.
Published: September 2016

Purpose

Pneumonitis is an uncommon but potentially fatal toxicity of anti–programmed death-1 (PD-1)/programmed death ligand 1 (PD-L1) monoclonal antibodies (mAbs). Clinical, radiologic, and pathologic features are poorly described.

Methods

Patients who received anti–PD-1/PD-L1 monotherapy or in combination with anti–cytotoxic T-cell lymphocyte associated antigen-4 mAb were identified at two institutions (Memorial Sloan Kettering Cancer Center: advanced solid cancers, 2009 to 2014, and Melanoma Institute of Australia: melanomas only, 2013 to 2015). Pneumonitis was diagnosed by the treating investigator; cases with confirmed malignant lung infiltration or infection were excluded. Clinical, radiologic, and pathologic features of pneumonitis were collected. Associations among pneumonitis incidence, therapy received, and underlying malignancy were examined with Fisher’s exact test as were associations between pneumonitis features and outcomes.

Results

Of 915 patients who received anti–PD-1/PD-L1 mAbs, pneumonitis developed in 43 (5%; 95% CI, 3% to 6%; Memorial Sloan Kettering Cancer Center, 27 of 578 [5%]; Melanoma Institute of Australia, 16 of 337 [5%]). Time to onset of pneumonitis ranged from 9 days to 19.2 months. The incidence of pneumonitis was higher with combination immunotherapy versus monotherapy (19 of 199 [10%] v 24 of 716 [3%]; P < .01). Incidence was similar in patients with melanoma and non–small-cell lung cancer (overall, 26 of 532 [5%] v nine of 209 [4%]; monotherapy, 15 of 417 v five of 152 [ P = 1.0]; combination, 11 of 115 v four of 57 [ P = .78]). Seventy-two percent (31 of 43) of cases were grade 1 to 2, and 86% (37 of 43) improved/resolved with drug holding/immunosuppression. Five patients worsened clinically and died during the course of pneumonitis treatment; proximal cause of death was pneumonitis (n = 1), infection related to immunosuppression (n = 3), or progressive cancer (n = 1). Radiologic and pathologic features of pneumonitis were diverse.

Conclusion

Pneumonitis associated with anti–PD-1/PD-L1 mAbs is a toxicity of variable onset and clinical, radiologic, and pathologic appearances. It is more common when anti–PD-1/PD-L1 mAbs are combined with anti–cytotoxic T-cell lymphocyte associated antigen-4 mAb. Most events are low grade and improve/resolve with drug holding/immunosuppression. Rarely, pneumonitis worsens despite immunosuppression, and may result in infection and/or death.
Statins Are Associated With Reduced Mortality in Multiple Myeloma
Authors: Sanfilippo Kristen Marie , Keller Jesse , Gage Brian F. , Luo Suhong , Wang Tzu-Fei , Moskowitz Gerald , Gumbel Jason , Blue Brandon , O’Brian Katiuscia , Carson Kenneth R.
Published: September 2016

Purpose

The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) have activity in one of the pathways influenced by nitrogen-containing bisphosphonates, which are associated with improved survival in multiple myeloma (MM). To understand the benefit of statins in MM, we evaluated the association between statin use and mortality in a large cohort of patients with MM.

Patients and Methods

From the Veterans Administration Central Cancer Registry, we identified patients diagnosed with MM between 1999 and 2013. We defined statin use as the presence of any prescription for a statin within 3 months before or any time after MM diagnosis. Cox proportional hazards regression assessed the association of statin use with mortality, while controlling for known MM prognostic factors.

Results

We identified a cohort of 4,957 patients, of whom 2,294 received statin therapy. Statin use was associated with a 21% decrease in all-cause mortality (adjusted hazard ratio, 0.79; 95% CI, 0.73 to 0.86; P < .001) as well as a 24% decrease in MM-specific mortality (adjusted hazard ratio, 0.76; 95% CI, 0.67 to 0.86; P < .001). This association remained significant across all sensitivity analyses. In addition to reductions in mortality, statin use was associated with a 31% decreased risk of developing a skeletal-related event.

Conclusion

In this cohort study of US veterans with MM, statin therapy was associated with a reduced risk of both all-cause and MM-specific mortality. Our findings suggest a potential role for statin therapy in patients with MM. The putative benefit of statin therapy in MM should be corroborated in prospective studies.
The Risk of Preeclampsia According to High Thyroid Function in Pregnancy Differs by hCG Concentration
Authors: Korevaar Tim I. M. , Steegers Eric A. P. , Chaker Layal , Medici Marco , Jaddoe Vincent W. V. , Visser Theo J. , de Rijke Yolanda B. , Peeters Robin P.
Published: September 2016

Context:

During pregnancy, there is an increased demand for thyroid hormone. The pregnancy hormone human chorionic gonadotropin (hCG) is an important physiological stimulator of thyroid function. Already high-normal maternal free T4 concentrations are associated with a higher risk of preeclampsia.

Objective:

The objective of the investigation was to study our hypothesis that hCG concentrations can distinguish a physiological form of high thyroid function from a more pathological form of high thyroid function and that the risk of preeclampsia would differ accordingly.

Design:

TSH, free T4, hCG, or thyroperoxidase antibody concentrations were determined in pregnant women participating in a population-based prospective cohort study.

Setting:

The study was conducted in the general community.

Participants:

A nonselected sample of 5146 pregnant women participated in the study.

Interventions:

There were no interventions.

Main Outcome Measure(s):

Preeclampsia was measured.

Results:

Women with high hCG-associated high thyroid function did not have a higher risk of preeclampsia than women with normal thyroid function. In contrast, women with low hCG and high thyroid function had a 3.4- to 11.1-fold higher risk of preeclampsia. These risk estimates were amplified in women with a high body mass index. Women with a low hCG and suppressed TSH (<0.10 mU/L) had a 3.2- to 8.9-fold higher risk of preeclampsia. hCG was not associated with preeclampsia, and results remained similar after exclusion of thyroperoxidase antibody-positive women.

Conclusion:

This study suggests that, in contrast to women with a high hCG associated high thyroid function, women with low hCG and high thyroid function during pregnancy are at a higher risk of developing preeclampsia. The additional measurement of hCG may therefore help to distinguish a more pathological form of high thyroid function and women at a high risk of preeclampsia.
Intraoperative Real-Time Localization of Normal Parathyroid Glands With Autofluorescence Imaging
Authors: Kim Sung Won , Song Seo Hyun , Lee Hyoung Shin , Noh Woong Jae , Oak Chulho , Ahn Yeh-Chan , Lee Kang Dae
Published: September 2016

Context:

This biomedical investigation is valuable for identification and localization of parathyroid glands during thyroidectomy, which can provide an intraoperative real-time visual guidance.

Objective:

The objective of the study was to investigate the feasibility of real-time autofluorescence imaging of the parathyroid glands without exogenous contrast dye for their localization and demonstration of relation to the background tissues.

Setting:

This research was undertaken at Kosin University Gospel Hospital.

Methods:

Sixteen normal parathyroid glands from eight patients with papillary thyroid carcinoma were enrolled. Photo images of the surgical field including the parathyroid and background tissues were taken with a digital camera, 780 nm light-emitting diode to excite the parathyroid, and infrared illuminator to visualize the entire neck. The area-averaged autofluorescence intensity of parathyroid over the area-averaged fluorescence intensity of background tissues was measured.

Main Outcome Measure:

The location of the parathyroid gland was verified with a single image.

Results:

The area-averaged autofluorescence intensity of parathyroid over the area-averaged fluorescence intensity of background tissues for all parathyroid glands was higher than 1, with a minimum of 1.95 and a maximum of 5.20 (average 2.76, SD 0.79). By our technique, all 16 parathyroid glands were detected (positive predictive value of 100%), and the entire surgical field including the parathyroid and background tissues was visualized as well. The parathyroid glands that were exposed or even covered by connective tissues or blood vessels could be detected with strong emission.

Conclusions:

This method showed the precise localization of the parathyroid glands and demonstrated their relation to background tissue. We believe that this simple, nonexogenous dye technique of anatomical guidance can aid surgeons to preserve parathyroid glands during thyroidectomy.
Σχόλιο στα «Επτανησιακά Μονόφυλλα»
Authors: Ασδραχάς Σπ. Ι.
Published: September 2016

No abstract
Αθανάσιος Δ. Χατζηδήμος
Authors: Δημαράς Κ. Θ.
Published: September 2016

No abstract
Η έρευνα στην Νοτιοανατολική Ευρώπη
Authors: Νυσταζοπούλου Μαρία Γ.
Published: September 2016

No abstract
Γιατί διορθώνουμε;
Authors: Δημαράς Κ. Θ.
Published: September 2016

No abstract
Οι παραλείψεις στις Βιβλιογραφίες
Authors: Γκίνης Δημήτριος Σ.
Published: September 2016

No abstract
Μιχαήλ Θ. Λάσκαρις
Authors: Κουμαριανού Αικ.
Published: September 2016

No abstract
Βηλαρικά σημειώματα Β΄
Authors: Βρανούσης Λ. Ι.
Published: September 2016

No abstract
Αντώνιος Στρατηγός (Βιοβιβλιογραφικές έρευνες)
Authors: Δημαράς Κ. Θ.
Published: September 2016

No abstract
Note sur l'article de Monsieur Sandor Baumgarten
Authors: Dimaras C. Th.
Published: September 2016

No abstract
Ο άλλοτε «Κώδιξ Φροντιστηρίου Τραπεζούντος 16» και ο Ιωάννης ιερεύς και Οικονόμος Τραπεζούντος
Authors: Μπενάκης Λίνος Γ.
Published: September 2016

No abstract
Early modern Greek printed books in the library of the British School at Athens
Authors: Clogg Richard
Published: September 2016

No abstract
I Greci a Venezia e la loro posizione religiosa nel XVo secolo (Studio su documenti veneziani)
Authors: Μοσχονάς Nικ. Γ.
Published: September 2016

No abstract
Οι πρώτες εκδόσεις της Ιστορίας του Κ. Παπαρρηγοπούλου
Authors: Δημαράς Κ. Θ.
Published: September 2016

No abstract
Τα γεγονότα του 1808 στην Κωνσταντινούπολη. Νέες ελληνικές μαρτυρίες
Authors: Κουμαριανού Αικατερίνη
Published: September 2016

No abstract
Πατμιακά (H μαρτυρία δύο βιβλιογραφικών προσθηκών)
Authors: Κομίνης Αθανάσιος Δ.
Published: September 2016

No abstract
Η πρώτη νεοελληνική βιβλιογραφία του Α. Παπαδοπούλου–Βρετού
Authors: Μακρυμίχαλος Στέφανος Ι.
Published: September 2016

No abstract
Δύο ακόμη αθησαύριστα απόγραφα του «Ρωσσαγγλογάλλου»
Authors: Δημαράς Κ. Θ.
Published: September 2016

No abstract
Γεώργιος Α. Μαυροκορδάτος. Βιβλιογραφική συμβολή
Authors: Μοσχονάς Εμμ. Ι.
Published: September 2016

No abstract
Μεταφράσεις και πρωτότυπα κείμενα από τον 18° αιώνα (Περιγραφή ενός κώδικα)
Authors: Μουλλάς Παν.
Published: September 2016

No abstract
Βιβλιογραφικά στον 16ο αιώνα (Ο Κερκυραίος γιατρός Άγγελος Φορτίας alias Angelo Forte)
Authors: Vitti Mario
Published: September 2016

No abstract
Η συλλογή δημοτικών τραγουδιών του Α. Μανούσου. Βιβλιογραφικές παρατηρήσεις
Authors: Παγώνη Χριστίνα
Published: September 2016

No abstract
Ελληνική Βιβλιογραφία 1800–1863. Διορθώσεις και Συμπληρώσεις
Authors: Μοσχονάς Εμμ. Ι.
Published: September 2016

No abstract
Καλλινίκου Δ': Συμπλήρωμα στην «Επαρίθμηση» του Δ. Προκοπίου
Authors: Αγγέλου Άλκης
Published: September 2016

No abstract
Η «Αιτωλία και Ακαρνανία του Μεσαιώνος» του Χριστοφόρου Κοντού (1839-1869)
Authors: Ασδραχάς Σπ. Ι.
Published: September 2016

No abstract
Ιωάννης Δονάς Πασχάλης (1761-1839) (Δυο άγνωστες νεκρολογίες του)
Authors: Ασδραχάς Σπ. Ι.
Published: September 2016

No abstract
Διορθώσεις, συμπληρώσεις και προσθήκες στο «Répertoire» του M. Richard
Authors: Γκίνης Δημ. Σ.
Published: September 2016

No abstract
Quelques lettres echangées entre J. G. Eynard et A. Louriotis en 1826 et au début de 1827
Authors: Dimakis Jean
Published: September 2016

No abstract
Ελληνο-Πολωνικά του 18ου αι.
Authors: Θωμόπουλος Ι. Α.
Published: September 2016

No abstract
Η παρουσίαση από τον Ιανό Λάσκαρη των πρώτων μαθητών του Ελληνικού Γυμνασίου της Ρώμης στον Πάπα Λέοντα Ι' (15 Φεβρουαρίου 1514)
Authors: Μανούσακας Μ. Ι.
Published: September 2016

No abstract
Η «Συνοπτική έκθεσις των Κασσίων αγώνων» του Ν. Γρηγοριάδη
Authors: Μαυρής Ν. Γ.
Published: September 2016

No abstract
Περιγραφή των χειρογράφων του Κέντρου Νεοελληνικών Ερευνών του Β.Ι.Ε.
Authors: Ρέγκου–Σγουρού Ευγενία
Published: September 2016

No abstract
Ανδρέας Κάλβος. Ανέκδοτα και αθησαύριστα κείμενα
Authors: Ασδραχάς Σπ. Ι.
Published: September 2016

No abstract
Ένα βιβλιογραφικό σχόλιο στον Σπ. Ζαμπέλιο
Authors: Ασδραχάς Σπ. Ι.
Published: September 2016

No abstract
Ο Δημήτριος Υψηλάντης κατεβαίνει στην Ελλάδα
Authors: Γκίνης Δημήτριος Σ.
Published: September 2016

No abstract
G. Zaviras Übersetzer von Cornelius Nepos
Authors: Füves Ödön
Published: September 2016

No abstract
Το «Βιβλίον ωραιότατον» και ο συγγραφέας του
Authors: Κακουλίδη Ελένη Δ.
Published: September 2016

No abstract
Το «Giornale» του Αριστείδη Κιαπίνη. Συνεργάτες και περιεχόμενα
Authors: Κονόμος Ντίνος
Published: September 2016

No abstract
Ανθίμου Γαζή «Λεξικόν Ελληνικόν». Η ιστορία μιας λεξικογραφικής προσπάθειας
Authors: Κουμαριανού Αικατερίνη
Published: September 2016

No abstract
Άγνωστη βενετική έκδοση της «Θυσίας του Αβραάμ»
Authors: Αλισανδράτος Γ. Γ.
Published: September 2016

No abstract
Ελληνική Βιβλιογραφία 1800–1863. Προσθήκες
Authors: Βελουδής Γιώργος
Published: September 2016

No abstract
Αι Κυβερνητικαί Αρχαί της Ελληνικής Πολιτείας (1827-1833)
Authors: Δημακόπουλος Γεώργιος Δ.
Published: September 2016

No abstract
Ελληνική μετάφραση του Δον Κιχώτη (περιγραφή ενός κώδικα)
Authors: Δρούλια Λουκία
Published: September 2016

No abstract
Bibliothek eines Griechen in Pest im Jahre 1820
Authors: Füves Ödön
Published: September 2016

No abstract
Alcuni momenti italiani di Tertsetis
Authors: Vitti M.
Published: September 2016

No abstract
Plasticity of the Leishmania genome leading to gene copy number variations and drug resistance
Authors: Laffitte Marie-Claude N. , Leprohon Philippe , Papadopoulou Barbara , Ouellette Marc
Published: September 2016

Leishmaniahas a plastic genome, and drug pressure can select for gene copy number variation (CNV). CNVs can apply either to whole chromosomes, leading to aneuploidy, or to specific genomic regions. For the latter, the amplification of chromosomal regions occurs at the level of homologous direct or inverted repeated sequences leading to extrachromosomal circular or linear amplified DNAs. This ability ofLeishmaniato respond to drug pressure by CNVs has led to the development of genomic screens such as Cos-Seq, which has the potential of expediting the discovery of drug targets for novel promising drug candidates.
Routes into a career in practice nursing: Trainee GPN perspective
Authors: Nicholson Ellen , East Debbie , Adio Fatima
Published: September 2016

The 12-month programme run by City and Hackney GP Confederation has now been running for over 6 months. In this article the perspective of two trainee general practice nurses, one newly-qualified and one with experience in secondary care, is considered and contrasted

The recent article ‘Managing workforce planning in primary care: innovation in practice’ ( Nicholson 2016 ) focused on the implementation of a 12-month programme in City and Hackney in conjunction with City University, London training registered nurses new to general practice nursing. This article addresses the role that clinical supervision plays in increasing clinical competence and confidence of the trainee general practice nurses and we meet two City and Hackney based trainee general practice nurses. Both nurses outline their distinct routes into a practice nursing career and share their thoughts and experiences of the reality of working as a practice nurse.
COGNITIVE MAPS AND AHP FOR SUPPLIER SELECTION IN A PRIVATE HIGHER EDUCATION INSTITUTION
Authors: Pegetti Ana Lucia , De Souza Jr Jesse D´Assunção Rebello
Published: September 2016

Supplier selection is a key decision in the procurement and purchasing processes. Both the choice of criteria and the evaluation of possible alternatives are critical steps in this decision-making process. One of the great challenges of private higher education institutions (PHEI) in Brazil in recent decades has been the attempt to institutionalize administrative practices applied in the business market. The primary goal of this is to optimize their business processes and achieve reduced risks and operational costs, thereby increasing their productivity and the quality of services. These initiatives aim to maintain self-sustaining and competitive institutions in an aggressive market that is constantly expanding. Therefore, a critical and professionalized look at their business processes has been one of the solutions for the PHEI to achieve their organizational goals. In this context, this paper proposes to formalize the decision-making process for the selection of suppliers through their systematization using cognitive maps to structure and identify the criteria that effectively present value during the partner selection of the decision-maker's procurement and purchasing department. The paper also proposes the subsequent prioritization of these criteria for evaluation and selection of potential suppliers by using the AHP multi-criteria method.
FIVE WAYS TO COMBINE TANGIBLES WITH INTANGIBLES
Authors: Saaty Thomas L.
Published: September 2016

This paper presents five different ways to establish weights for the criteria that govern making comparisons.  Four of these can be done in the context of the AHP, but the fifth and most reliable one is obtained by using the ANP.
IJAHP and the Next Generation of AHP/ANP Scholars
Authors: Mu Enrique
Published: September 2016

Writing a good journal article requires experience. The earlier prospective scholars start writing articles for a journal, the sooner they will learn the art of writing good journal articles. It is for this reason that this journal encourages young scholars and practitioners, whom we consider the next generation of AHP/ANP scholars, to submit their papers to this academic outlet. Our editorial board makes an extra effort in assisting the authors to edit the paper to make it not only comprehensible but also engaging for our readers.
AHP Book Announcements
Authors: Petrillo Antonella , Mu Enrique
Published: September 2016

Two more books are added to the AHP bibliography this month: First, a book titled Applications and Theory in Analytic Hierarchy Process - Decision Making for Strategic Decisions, edited by Fabio de Felice, Thomas L. Saaty and Antonella Petrillo.  The second book is Practical Decision Making: Introduction to the Analytic Hierarchy Process using Super Decisions v2, written by Enrique Mu and Milagros Pereyra-Rojas and publish by Springer.
Arsenic Trioxide and Tretinoin (AsO/ATRA) for Acute Promyelocytic Leukemia (APL)
Authors: Damery Erin , Solimando Dominic A. , Waddell J. Aubrey
Published: September 2016

The complexity of cancer chemotherapy requires pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy, and the agents, both commercially available and investigational, used to treat malignant diseases.
Leadership Book Club: An Innovative Strategy to Incorporate Leadership Development into Pharmacy Residency Programs
Authors: Chappell Alyssa , Dervay Katelyn
Published: September 2016

Purpose

To describe an innovative strategy for incorporating leadership training and development across multiple postgraduate year 2 (PGY2) pharmacy residency programs at a single institution.

Background

Tampa General Hospital has 7 pharmacy residency positions: 4 postgraduate year 1 (PGY1) residents and a single resident for each of the 3 PGY2 programs (critical care, emergency medicine, and solid organ transplant). Administrative topics are incorporated across the PGY1 and PGY2 residency programs, with each PGY2 program having additional administrative topics specific to their specialty area.

What began as an elective administrative topic discussion for the PGY2 emergency medicine resident has evolved over time into a longitudinal leadership book club. The leadership book club is utilized to meet the residency goals and objectives related to leadership development for all 3 PGY2 programs. Each year a single book is identified through the American Society of Health-System Pharmacists (ASHP) Leadership Academy book list or by participant suggestion. The book is then divided into 4 sections with corresponding hour-long discussions that occur quarterly throughout the residency year. The residency program directors (RPDs) and co-RPDs lead the initial discussion, and each PGY2 resident leads 1 of the subsequent 3 discussions. Based on resident feedback, the leadership book club is an innovative and effective strategy to incorporate leadership training and development into residency training.

Conclusion

It is imperative to foster the development of leadership skills in pharmacy residency programs to prevent a future leadership gap in health system pharmacy. Leadership book club is a unique strategy to incorporate leadership training longitudinally across multiple PGY2 residency programs at a single institution.
Guidelines for the Establishment of Appropriate beyond Use Dating of Sterile Compounded Admixtures
Authors: Engel Jamin , Lazar Nicole
Published: September 2016

To support compounding of products that are sterile and chemically stable, beyond use dating of admixtures must include a thorough evaluation of appropriate resources. In most instances, resources provide documentation of a specific compounded admixture, at a specific concentration and storage parameters, that does not coincide with current operations or patient-specific requirements. To meet the operational demands of a pharmacy, institutions employ a referenced guideline approach to guide decision making for safe sterile admixing. Often these guidelines are established and maintained at individual practicing locations with varying levels of detail and accuracy. In an effort to improve sterile compounding across a multihospital system, we developed and implemented beyond use dating guidelines to improve consistency and patient safety while meeting regulatory concerns.
Comparison of Time to Therapeutic aPTT in Patients who Received Continuous Unfractionated Heparin after Implementation of Pharmacy-wide Intervention Alerts
Authors: Alsulaiman Duaa , Sylvester Katelyn , Stevens Craig , Carter Danielle
Published: September 2016

Background

For patients on continuous IV unfractionated heparin (UFH), failing to achieve a therapeutic aPTT by 24 hours can be associated with increased morbidity. A pharmacy clinical surveillance system (PCSS) subtherapeutic aPTT alert was implemented at our institution to improve achievement of therapeutic aPTT goals by 24 hours.

Objective

The primary objective was the time to achieve the minimum goal aPTT before and after the alert implementation. The secondary objectives were to examine the percentage of patients who achieved the minimum goal aPTT by 24 hours and the number of dose changes to achieve the minimum goal aPTT

Methods

A single-center retrospective study was conducted to include all adult inpatients receiving a continuous UFH infusion during a 3-month period prior to the implementation of a subtherapeutic aPTT alert and a 3-month period after implementation.

Results

317 patients were included in the analysis. The average time to achieve the minimum goal aPTT was 21.8 hours prior to alert implementation and 15.4 hours after implementation ( p = .002). The percent of patients who achieved the minimum goal aPTT by 24 hours was 65.7% prior to alert implementation and 82.4% after implementation ( p = .035). The average number of dose changes necessary to achieve aPTT value to the minimum goal aPTT prior to alert implementation was 1.67 and 1. 98 after implementation ( p = .68).

Conclusion

This analysis showed that implementation of a PCSS subtherapeutic aPTT alert for patients on continuous UFH infusions may ensure patients reach goal aPTT faster and facilitate a higher percent of patients who achieve the minimum goal aPTT by 24 hours.
Consider Adopting Collaborative Project Management Software
Authors: Fox Brent I. , Felkey Bill G.
Published: September 2016

Pharmacy administrators are often tasked with a range of responsibilities, from strategic planning and human resources to information systems management. Because of this, tools to support administrators' efficient and appropriate attention to everything on their plate can be valuable. Identification and evaluation of the available tools should be guided by careful consideration of the department's needs.
Paradigmatic perspective for development of an educational programme to facilitate critical thinking of student nurses in Namibia
Authors: Pretorius Louise , Van Dyk Agenes , Small Louis , Amukugo Hans Justus
Published: September 2016

This research paper is focuses on describing the paradigmatic perspective used for development of an educational programme to facilitate critical thinking of student nurses. The study of this nature requires a paradigmatic perspective this is a collection of logically linked concepts and propositions that provide a theoretical perspective or orientation that tends to guide the research approach to a specific direction.The study was conducted in four phases, beginning with the needs assessment in phase 1 through which the researcher determine the needs of the students in terms of critical thinking, followed by phase 2 on the development of an educational framework and phase 3 and 4 on implementation and evaluation and this two phases were conducted simultaneously.The positivistic paradigm allows the researcher to be orderly and disciplined in the procedures followed during the study to acquire information. For this study the researcher worked according to a specific and logical plan of action and conducted the research in a series of steps. In this study the paradigm consisted meta-theoretical such as ontological, epistemological, axiological and methodological assumption. The theoretical basis of this study included the principal of adult learning; Model of curriculum development; Nicholas and Nichols; Viedebeck’s model of teaching critical thinking and Theoretical principle of constructivism. These theoretical frameworks were applied in respectively in the phases listed above.
Pseudomonas aeruginosa in otitis media
Authors: Umar Jidda B , Ibrahim Muhammad M. , Tom Isyaka M. , Umoru Askira M , Isa Tijjani
Published: September 2016

Background: Over 50% of cases of otitis media are caused by bacteria and Pseudomonas aeruginosa is the most common aetiologic agent implicated in the pathology of the disease.Objectives: This study is designed to examine the influence of Pseudomonas aeruginosa in otitis media disease, and further look at the susceptibility pattern of the organism to commonly prescribed antimicrobial drugs.Methods: Eighty two (82) swab samples were randomly collected from otitis media patients attending the ENT clinic of the University of Maiduguri Teaching Hospital and cultured for bacterial recovery. Further biochemical tests were conducted. Antimicrobial susceptibility test was performed and susceptibility pattern recorded.Results: Nineteen (19) samples yielded growth of Pseudomonas aeruginosa, which gives a recovery rate of 23.2%. The rate was higher among males (12.2%) than females (11.0%). The rate of isolation was highest among patients of the age category of 0-14yrs (11.0%) and least among those of >44yrs (2.0%). Isolates were highly sensitive to Ciprofloxacin, Ofloxacin and Peflacin but highly resistant to Nalidixic acid and Ampicillin.Conclusions: The infection is highest among children whose immune competence is still developing and as such, it is recommended that treatment should be based on results obtained from in-vitro susceptibility test, and that combination therapy should be considered to forestall chances of emergence of drug resistance.
Water, Moisture, and Ash Content of Mechanically-Cleaned Greige Cotton, Naturally-Colored Brown Cotton, Flax, and Rayon
Authors: Montalvo Joe , Von Hoven Terri , Easson Michael , Hinchliffe Doug
Published: September 2016

This exploratory research evaluated the Karl Fischer Titration (KFT) reference method (ASTM D7785) to accurately measure water content of mechanically-cleaned greige cotton, a naturally-colored brown cotton, flax, and rayon at moisture equilibrium. Each sample was analyzed by KFT, standard oven drying in ambient air, and isothermal thermogravimetric analysis (TGA) using dry air and nitrogen carrier gases. Water content, as measured by KFT, was (%): mechanically-cleaned greige cotton, 6.82, brown cotton, 7.88, flax, 8.72, and rayon, 11.74. There was a significant difference between water and moisture contents by standard oven drying. Similar differences were observed between TGA in air and nitrogen and varied with ash content. The findings support the use of KFT to determine water content of these diverse cellulosic textile fibers.
Soldier Hygiene Issues and Use of Antimicrobial Textiles in the Military
Authors: Spitz Marissa G. , Johnson Wendy K. , Lesher Larry L. , Arcidiacono Steven
Published: September 2016

Antimicrobial treatments are being incorporated into various military items, including T-shirts, socks, and sleeping bag liners, to address a variety of soldier hygiene issues such as odor, athlete's foot, and skin irritation. For any medical or hygiene issue, it is not known what performance constitutes an effective treatment, or if existing treatments are providing a benefit and positive return on investment. The effect of prolonged wear of treated textiles on the skin has not been examined. While treatments provide perceived benefits, existing methods to assess efficacy in military-relevant environments are lacking. Current Army efforts are underway to define the magnitude of soldier hygiene issues, determine performance for an effective treatment, and investigate test methods to acquire meaningful data.
Zero mass case for a fractional Berestycki–Lions-type problem
Authors: Ambrosio Vincenzo
Published: September 2016

In this work we study the following fractional scalar field equation:

{(-Δ)s⁢u=g′⁢(u) in ⁢ℝN,u>0,\left\{\begin{aligned} \displaystyle(-\Delta)^{s}u&\displaystyle=g^{\prime}(u)% \quad\mbox{in }\mathbb{R}^{N},\\ \displaystyle u&\displaystyle>0,\end{aligned}\right.

whereN≥2{N\geq 2},s∈(0,1){s\in(0,1)},(-Δ)s{(-\Delta)^{s}}is the fractional Laplacian and the nonlinearityg∈C2⁢(ℝ){g\in C^{2}(\mathbb{R})}is such thatg′′⁢(0)=0{g^{\prime\prime}(0)=0}. By using variational methods, we prove the existence of a positive solution which is spherically symmetric and decreasing inr=|x|{r=|x|}.
The Italian Way: Urban Planning Heritage in Albania
Authors: Resta Giuseppe
Published: September 2016

The paper is focused on ageism in urban planning, taking the Italian WWII planning heritage in Albania as a case study. It expounds three main issues: acknowledgment of modern heritage, dissemination of autocratic identity, and historical planning apparatus. The text investigates autocratic plans as purest fulfilment of Euclidean space, before relentless urban transformations affect cities.
Revitalization of Traditional Architecture Towards Sustainable Development of the Skadar Lake Area
Authors: Rajković Irena , Bojović Marija
Published: September 2016

Traditional architecture is one of the most important segments in the preservation and development of cultural identity. The Lake Skadar region abounds in examples of vernacular building activity that provide the clearest evidence of the creation of settlements and houses as a result of adaptation to natural environment. The study of vernacular architecture on the shores of Lake Skadar is related to the identification and potential evaluation of its local traditional features, as ecological building forms which express the principle of sustainability. Within the framework of research on vernacular architecture of this area, analysis is undertaken with the aim of defining guidelines for revitalizing traditional settlements in this region. In this respect the emphasis of this work is on recognizing the potential and possible directions in revitalization of cultural heritage of traditional settlements in keeping with the principles of sustainable development.
Methodology in Attitudes Assigned to Architecture as Distinctly Regional
Authors: Miķelsone Ilze
Published: September 2016

Regionalism as a research subject in the built environment indicates notable complexity. This subject is complex by facing multi layered disciplines, it is questioned in time and it has a plural structure, ontological, intellectual and emotional. Presuming that regionalism concepts specifically in architecture are not much more than conjectures andattitudes assigned to it,the purpose of this study is examination of attitudes in order to correlate them with methodological tools.
Occurrence of Thanatus atratus Simon, 1875 (Araneae: Philodromidae) in Poland
Authors: Rozwałka Robert , Rutkowski Tomasz , Staręga Wojciech , Sienkiewicz Paweł
Published: September 2016

The paper presents data on the occurrence of Thanatus atratus in Poland. The long-lasting confusion in Polish and European literature about the existence of 2 similar species T. atratus / T. vulgaris in Poland is clarified. Diagnostic images of T. atratus reproductive organs of both sexes are presented.
Populism in Lithuania: Defining the Research Tradition
Authors: Aleknonis Gintaras , Matkevičienė Renata
Published: September 2016

The research on populism and populist political communication in Lithuania is rather limited, regardless of the fact that populist movements and politicians are influential on national and local political levels; they also receive sufficient support from a significant share of the population. Because the Western European research tradition is concentrated on the challenges of right-wing populism, Lithuanian political scientists distinguish right-wing populism as more significant in comparison to left-wing populism. Although Lithuanian researchers note, that in the balance of the left-right wing populists, Lithuania stands out with the majority of left-wing populists, in comparison to the popularity and number of right-wing populists in neighbouring countries.

Despite the interest of scholars in various fields of policy research in Lithuania, there is still a lack of research on populist political communication, and what interest does exist is mostly concentrated on analysis of practical issues within the political arena, e.g. the study of the processes of political elections.

The analysis of populist political communication in Lithuania revealed that populism is a relatively oft-mentioned topic in Lithuanian scientific discourse, but in most cases remains on the margins of other research. The theoretical work presents the assumptions based on the analysis of the political situation in Lithuania and examples from other countries. The empirical research of populism is scarce, and in most cases based on content analysis of political documents and media reports.
From Politicization to Securitization of Maritime Security in the Gulf of Guinea
Authors: Piedade João
Published: September 2016

EU’s Energy security and trade depend, to a large extent, on sea-based transport relying on open sea lines of communication and Maritime Security. The Gulf of Guinea (GoG) region has supplied 13 per cent of oil and six per cent of total EU28 consumption. Between 2003 and January 2015, piracy in the GoG accounted for 31 per cent of attacks (616 of 1,965) in African waters. With that proportion on the rise and a growing threat related to Piracy, illegal over-fishing and crude oil theft; maritime (in)security in the region is attracting attention from regional and international governments and bodies.

In this context, and considering politicization as a more extreme version or a step to securitization, this paper analyses how an issue is brought up to the level of security by a speech act, namely, explaining how issues are politicized and securitized within the maritime domain and what strategies are involved.

A number of institutions are currently acting to secure the Gulf of Guinea with growing co-operation between the region and extra-regional actors. However, the lack of capabilities, weak governance within the region and the willingness to take action from extra-regional actors have undermined the securitization, and thus, the Gulf of Guinea has remained politicized.
Crossed modules as maps between connected components of topological groups
Authors: Farjoun Emmanuel D. , Segev Yoav
Published: September 2016

The purpose of this paper is to observe that a homomorphism of discrete groups

f
:

Γ
→
G

{f:\Gamma\to G}

arises as
the induced map

π
0

⁢

(
𝔐
)

→

π
0

⁢

(
𝔛
)

{\pi_{0}(\mathfrak{M})\to\pi_{0}(\mathfrak{X})}

on path components of some closed normal
inclusion of topological groups

𝔐
⊆
𝔛

{\mathfrak{M}\subseteq\mathfrak{X}}

if and only if
the map f can be equipped with a crossed module structure.
In that case an essentially unique realization

𝔐
⊆
𝔛

{\mathfrak{M}\subseteq\mathfrak{X}}

exists by homotopically discrete topological groups.
The results here are topological elaboration and exposition using existing simplicial techniques.