bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Data from HER3 Is an Actionable Target in Advanced Prostate Cancer
Authors: Gil Veronica , Miranda Susana , Riisnaes Ruth , Gurel Bora , D’Ambrosio Mariantonietta , Vasciaveo Alessandro , Crespo Mateus , Ferreira Ana , Brina Daniela , Troiani Martina , Sharp Adam , Sheehan Beshara , Christova Rossitza , Seed George , Figueiredo Ines , Lambros Maryou , Dolling David , Rekowski Jan , Alajati Abdullah , Clarke Matthew , Pereira Rita , Flohr Penny , Fowler Gemma , Boysen Gunther , Sumanasuriya Semini , Bianchini Diletta , Rescigno Pasquale , Aversa Caterina , Tunariu Nina , Guo Christina , Paschalis Alec , Bertan Claudia , Buroni Lorenzo , Ning Jian , Carreira Suzanne , Workman Paul , Swain Amanda , Califano Andrea , Shen Michael M. , Alimonti Andrea , Neeb Antje , Welti Jonathan , Yuan Wei , de Bono Johann
Published: April 2023

Supplementary methods and Supplementary figure legends
Figure S5 from HER3 Is an Actionable Target in Advanced Prostate Cancer
Authors: Gil Veronica , Miranda Susana , Riisnaes Ruth , Gurel Bora , D’Ambrosio Mariantonietta , Vasciaveo Alessandro , Crespo Mateus , Ferreira Ana , Brina Daniela , Troiani Martina , Sharp Adam , Sheehan Beshara , Christova Rossitza , Seed George , Figueiredo Ines , Lambros Maryou , Dolling David , Rekowski Jan , Alajati Abdullah , Clarke Matthew , Pereira Rita , Flohr Penny , Fowler Gemma , Boysen Gunther , Sumanasuriya Semini , Bianchini Diletta , Rescigno Pasquale , Aversa Caterina , Tunariu Nina , Guo Christina , Paschalis Alec , Bertan Claudia , Buroni Lorenzo , Ning Jian , Carreira Suzanne , Workman Paul , Swain Amanda , Califano Andrea , Shen Michael M. , Alimonti Andrea , Neeb Antje , Welti Jonathan , Yuan Wei , de Bono Johann
Published: April 2023

Supplementary Figure S5
Supplementary Figures 1-8 from Repurposing Ceritinib Induces DNA Damage and Enhances PARP Inhibitor Responses in High-Grade Serous Ovarian Carcinoma
Authors: Kanakkanthara Arun , Hou Xiaonan , Ekstrom Thomas L. , Zanfagnin Valentina , Huehls Amelia M. , Kelly Rebecca L. , Ding Husheng , Larson Melissa C. , Vasmatzis George , Oberg Ann L. , Kaufmann Scott H. , Mansfield Aaron S. , Weroha S. John , Karnitz Larry M.
Published: April 2023

Supplementary Figures 1-8 with legends
Figure S4 from HER3 Is an Actionable Target in Advanced Prostate Cancer
Authors: Gil Veronica , Miranda Susana , Riisnaes Ruth , Gurel Bora , D’Ambrosio Mariantonietta , Vasciaveo Alessandro , Crespo Mateus , Ferreira Ana , Brina Daniela , Troiani Martina , Sharp Adam , Sheehan Beshara , Christova Rossitza , Seed George , Figueiredo Ines , Lambros Maryou , Dolling David , Rekowski Jan , Alajati Abdullah , Clarke Matthew , Pereira Rita , Flohr Penny , Fowler Gemma , Boysen Gunther , Sumanasuriya Semini , Bianchini Diletta , Rescigno Pasquale , Aversa Caterina , Tunariu Nina , Guo Christina , Paschalis Alec , Bertan Claudia , Buroni Lorenzo , Ning Jian , Carreira Suzanne , Workman Paul , Swain Amanda , Califano Andrea , Shen Michael M. , Alimonti Andrea , Neeb Antje , Welti Jonathan , Yuan Wei , de Bono Johann
Published: April 2023

Supplementary Figure S4
Figure S4 from Inhibition of ERK5 Elicits Cellular Senescence in Melanoma via the Cyclin-Dependent Kinase Inhibitor p21
Authors: Tubita Alessandro , Lombardi Zoe , Tusa Ignazia , Lazzeretti Azzurra , Sgrignani Giovanna , Papini Dimitri , Menconi Alessio , Gagliardi Sinforosa , Lulli Matteo , Dello Sbarba Persio , Esparís-Ogando Azucena , Pandiella Atanasio , Stecca Barbara , Rovida Elisabetta
Published: April 2023

Supplementary Figure S4 R1
Supplementary Table 4 from Super Enhancer-Mediated Upregulation of HJURP Promotes Growth and Survival of t(4;14)-Positive Multiple Myeloma
Authors: Jia Yunlu , Zhou Jianbiao , Tan Tze King , Chung Tae-Hoon , Chen Yongxia , Chooi Jing-Yuan , Sanda Takaomi , Fullwood Melissa J. , Xiong Sinan , Toh Sabrina H.M. , Balan Kalpnaa , Wong Regina W.J. , Lim Julia S.L. , Zhang Enfan , Cai Zhen , Shen Peng , Chng Wee Joo
Published: April 2023

Supplementary Table 4 shows the sequences of SE fragments inserted into pGL3 vector
Figure S3 from Inhibition of ERK5 Elicits Cellular Senescence in Melanoma via the Cyclin-Dependent Kinase Inhibitor p21
Authors: Tubita Alessandro , Lombardi Zoe , Tusa Ignazia , Lazzeretti Azzurra , Sgrignani Giovanna , Papini Dimitri , Menconi Alessio , Gagliardi Sinforosa , Lulli Matteo , Dello Sbarba Persio , Esparís-Ogando Azucena , Pandiella Atanasio , Stecca Barbara , Rovida Elisabetta
Published: April 2023

Supplementary Figure S3 R1
Supplementary Materials and Methods from Super Enhancer-Mediated Upregulation of HJURP Promotes Growth and Survival of t(4;14)-Positive Multiple Myeloma
Authors: Jia Yunlu , Zhou Jianbiao , Tan Tze King , Chung Tae-Hoon , Chen Yongxia , Chooi Jing-Yuan , Sanda Takaomi , Fullwood Melissa J. , Xiong Sinan , Toh Sabrina H.M. , Balan Kalpnaa , Wong Regina W.J. , Lim Julia S.L. , Zhang Enfan , Cai Zhen , Shen Peng , Chng Wee Joo
Published: April 2023

Supplementary Materials and Methods shows detailed descriptions of methodology or materials and methods used in this manuscript.
A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities
Authors: McNicholas Michael , De Cola Antonella , Bashardanesh Zahedeh , Foss Amelia , Lloyd Cameron B. , Hébert Steven , Faury Damien , Andrade Augusto Faria , Jabado Nada , Kleinman Claudia L. , Pathania Manav
Published: April 2023

Pediatric high-grade gliomas (pHGG) are lethal, incurable brain tumors frequently driven by clonal mutations in histone genes. They often harbor a range of additional genetic alterations that correlate with different ages, anatomic locations, and tumor subtypes. We developed models representing 16 pHGG subtypes driven by different combinations of alterations targeted to specific brain regions. Tumors developed with varying latencies and cell lines derived from these models engrafted in syngeneic, immunocompetent mice with high penetrance. Targeted drug screening revealed unexpected selective vulnerabilities—H3.3G34R/PDGFRAC235Y to FGFR inhibition, H3.3K27M/PDGFRAWT to PDGFRA inhibition, and H3.3K27M/PDGFRAWT and H3.3K27M/PPM1DΔC/PIK3CAE545K to combined inhibition of MEK and PIK3CA. Moreover, H3.3K27M tumors with PIK3CA, NF1, and FGFR1 mutations were more invasive and harbored distinct additional phenotypes, such as exophytic spread, cranial nerve invasion, and spinal dissemination. Collectively, these models reveal that different partner alterations produce distinct effects on pHGG cellular composition, latency, invasiveness, and treatment sensitivity.

Significance:

Histone-mutant pediatric gliomas are a highly heterogeneous tumor entity. Different histone mutations correlate with different ages of onset, survival outcomes, brain regions, and partner alterations. We have developed models of histone-mutant gliomas that reflect this anatomic and genetic heterogeneity and provide evidence of subtype-specific biology and therapeutic targeting.

See related commentary by Lubanszky and Hawkins, p. 1516.

This article is highlighted in the In This Issue feature, p. 1501
Disruptive and Truncating TP53 Mutations Are Associated with African-Ancestry and Worse Prognosis in Brazilian Patients with Lung Adenocarcinoma
Authors: Cavagna Rodrigo de Oliveira , Pinto Icaro Alves , Escremim de Paula Flávia , Berardinelli Gustavo Noriz , Sant'Anna Débora , Santana Iara , da Silva Vinicius Duval , Da Silva Eduardo Caetano Albino , Miziara José Elias , Mourão Dias Josiane , Antoniazzi Augusto , Jacinto Alexandre , De Marchi Pedro , Molina-Vila Miguel Angel , Ferro Leal Leticia , Reis Rui Manuel
Published: April 2023

Introduction: TP53 is the most frequently mutated gene in lung tumors, but its prognostic role in admixed populations, such as Brazilians, remains unclear. In this study, we aimed to evaluate the frequency and clinicopathological impact of TP53 mutations in non-small cell lung cancer (NSCLC) patients in Brazil. Methods: We analyzed 446 NSCLC patients from Barretos Cancer Hospital. TP53 mutational status was evaluated through targeted next-generation sequencing (NGS) and the variants were biologically classified as disruptive/nondisruptive and as truncating/nontruncating. We also assessed genetic ancestry using 46 ancestry-informative markers. Analysis of lung adenocarcinomas from the cBioportal dataset was performed. We further examined associations of TP53 mutations with patients’ clinicopathological features. Results: TP53 mutations were detected in 64.3% (n = 287/446) of NSCLC cases, with a prevalence of 60.4% (n = 221/366) in lung adenocarcinomas. TP53 mutations were associated with brain metastasis at diagnosis, tobacco consumption, and higher African ancestry. Disruptive and truncating mutations were associated with a younger age at diagnosis. Additionally, cBioportal dataset revealed that TP53 mutations were associated with younger age and Black skin color. Patients harboring disruptive/truncating TP53 mutations had worse overall survival than nondisruptive/nontruncating and wild-type patients. Conclusion: TP53 mutations are common in Brazilian lung adenocarcinomas, and their biological characterization as disruptive and truncating mutations is associated with African ancestry and shorter overall survival.
Cardiovascular Health and Life Expectancy Among Adults in the United States
Authors: Ma Hao , Wang Xuan , Xue Qiaochu , Li Xiang , Liang Zhaoxia , Heianza Yoriko , Franco Oscar H. , Qi Lu
Published: April 2023

Background:

Cardiovascular disease may be the main reason for stagnant growth in life expectancy in the United States since 2010. The American Heart Association recently released an updated algorithm for evaluating cardiovascular health (CVH)—Life’s Essential 8 (LE8) score. We aimed to quantify the associations of CVH levels, estimated by the LE8 score, with life expectancy in a nationally representative sample of US adults.

Methods:

We included 23 003 nonpregnant, noninstitutionalized participants aged 20 to 79 years who participated in the National Health and Nutrition Examination Survey from 2005 to 2018 and whose mortality was identified through linkage to the National Death Index through December 31, 2019. The overall CVH was evaluated by the LE8 score (range, 0–100), as well as the score for each component of diet, physical activity, tobacco/nicotine exposure, sleep duration, body mass index, non–high-density lipoprotein cholesterol, blood glucose, and blood pressure. Life table method was used to estimate life expectancy by levels of the CVH.

Results:

During a median of 7.8 years of follow-up, 1359 total deaths occurred. The estimated life expectancy at age 50 years was 27.3 years (95% CI, 26.1–28.4), 32.9 years (95% CI, 32.3–33.4), and 36.2 years (95% CI, 34.2–38.2) in participants with low (LE8 score <50), moderate (50≤ LE8 score <80), and high (LE8 score ≥80) CVH, respectively. Equivalently, participants with high CVH had an average 8.9 (95% CI, 6.2–11.5) more years of life expectancy at age 50 years compared with those with low CVH. On average, 42.6% of the gained life expectancy at age 50 years from adhering to high CVH was attributable to reduced cardiovascular disease death. Similarly significant associations of CVH with life expectancy were observed in men and women, respectively. Similarly significant associations of CVH with life expectancy were observed in White participants and Black participants but not in Mexican participants.

Conclusions:

Adhering to a high CVH, defined as the LE8 score, is related to a considerably increased life expectancy in US adults, but more research needs to be done in other races and ethnicities (eg, Hispanic and Asian).
Angiotensin II–Mediated Neuroinflammation in the Hippocampus Contributes to Neuronal Deficits and Cognitive Impairment in Heart Failure Rats
Authors: Althammer Ferdinand , Roy Ranjan K. , Kirchner Matthew K. , Campos-Lira Elba , Whitley Kathryn E. , Davis Steven , Montanez Juliana , Ferreira-Neto Hildebrando Candido , Danh Jessica , Feresin Rafaela , Biancardi Vinicia Campana , Zafar Usama , Parent Marise B. , Stern Javier E.
Published: April 2023

Background:

Heart failure (HF) is a debilitating disease affecting >64 million people worldwide. In addition to impaired cardiovascular performance and associated systemic complications, most patients with HF suffer from depression and substantial cognitive decline. Although neuroinflammation and brain hypoperfusion occur in humans and rodents with HF, the underlying neuronal substrates, mechanisms, and their relative contribution to cognitive deficits in HF remains unknown.

Methods:

To address this critical gap in our knowledge, we used a well-established HF rat model that mimics clinical outcomes observed in the human population, along with a multidisciplinary approach combining behavioral, electrophysiological, neuroanatomical, molecular and systemic physiological approaches.

Results:

Our studies support neuroinflammation, hypoperfusion/hypoxia, and neuronal deficits in the hippocampus of HF rats, which correlated with the progression and severity of the disease. An increased expression of AT1aRs (Ang II [angiotensin II] receptor type 1a) in hippocampal microglia preceded the onset of neuroinflammation. Importantly, blockade of AT1Rs with a clinically used therapeutic drug (Losartan), and delivered in a clinically relevant manner, efficiently reversed neuroinflammatory end points (but not hypoxia ones), resulting in turn in improved cognitive performance in HF rats. Finally, we show than circulating Ang II can leak and access the hippocampal parenchyma in HF rats, constituting a possible source of Ang II initiating the neuroinflammatory signaling cascade in HF.

Conclusions:

In this study, we identified a neuronal substrate (hippocampus), a mechanism (Ang II–driven neuroinflammation) and a potential neuroprotective therapeutic target (AT1aRs) for the treatment of cognitive deficits in HF.
Deep Learning Solution of the Eigenvalue Problem for Differential Operators
Authors: Ben-Shaul Ido , Bar Leah , Fishelov Dalia , Sochen Nir
Published: April 2023

Solving the eigenvalue problem for differential operators is a common problem in many scientific fields. Classical numerical methods rely on intricate domain discretization and yield nonanalytic or nonsmooth approximations. We introduce a novel neural network–based solver for the eigenvalue problem of differential self-adjoint operators, where the eigenpairs are learned in an unsupervised end-to-end fashion. We propose several training procedures for solving increasingly challenging tasks toward the general eigenvalue problem. The proposed solver is capable of finding the M smallest eigenpairs for a general differential operator. We demonstrate the method on the Laplacian operator, which is of particular interest in image processing, computer vision, and shape analysis among many other applications. In addition, we solve the Legendre differential equation. Our proposed method simultaneously solves several eigenpairs and can be easily used on free-form domains. We exemplify it on L-shape and circular cut domains. A significant contribution of this work is an analysis of the numerical error of this method. In particular an upper bound for the (unknown) solution error is given in terms of the (measured) truncation error of the partial differential equation and the network structure.
Neonatal Hearing Screening: Challenges of COVID-19 Pandemic
Authors: Rockwell Michael , Gungor Anil , Pichilingue Reto Patricia , Manzar Shabih , Mankekar Gauri
Published: April 2023

This is a retrospective chart review of newborns referred to audiology between June and December 2020. Newborns who failed or did not have an initial newborn hearing screening (NBHS) at an academic, tertiary care medical center, either in the nursery or in the neonatal intensive care unit (NICU) prior to discharge, were referred for a follow-up audiology appointment. Forty-three patients were included who failed or did not receive an NBHS. Of 43 patients, 15 (34.9%) did not receive an initial hearing test due to coronavirus disease 2019 (COVID-19 protocols). Of the 15, 7 (16.3% of total 43) newborns had mothers who refused COVID-19 screening, and 5/7 were lost to follow-up (11.6% of total). Another 7/15 newborns (16.3% of total) had a COVID-19-positive mother, and 1 of these 7 was lost to follow-up (2.3% of total). One of the 15 newborns (2.3% of total) had a pending maternal COVID-19 test result at discharge, and this patient was also lost to follow-up.
“To Know There's Other Indigenous People in Your School is Nice”: Urban Indigenous Civic Identity
Authors: Talbert, Rachel
Published: April 2023

This critical participatory ethnographic study examines the negotiation of civic identity by eight Indigenous students in an urban public high school. Using Tribal Critical Race Theory to understand the experiences of students, stories from observations, participant interviews, and focus groups were employed as data. This study, examines data from a larger study and finds the studied school was vital as a civic site for these negotiations and a Zone of Sovereignty forwarding survivance and self-determination for Indigenous students.
Exploring and Implementing Available Writing Educational Technology for Students with Disabilities and Their Peers
Authors: Goldman Samantha R. , Carreon Adam , Smith Sean J. , Kurth Jennifer
Published: April 2023

Written expression is an area of the curriculum with which many students with disabilities (SWDs) struggle. One solution to mitigate the barriers associated with this topic is to use educational technology supports such as speech-to-text, text-to-speech, and predictive text. Even though there has been an increase in technology access in the classrooms, challenges still exist with regards to determining which tools support which students, training educators to use the tools, and training students to use the tools. This can be attributed to the time investment required for educators to learn new technologies. This article provides educators with the steps to introduce and implement an intervention where SWDs support the special educator in teaching general education peers to use Google’s Voice Typing.
Risk Narratives on Immigration During the COVID-19 Crisis in Italy: A Comparative Analysis of Facebook Posts Published by Politicians and by News media
Authors: Serafini Luca , Gottlob Anita , Pierri Francesco , Ieva Francesca , Ceri Stefano
Published: April 2023

This work explores how the narrative on immigration changes when society is threatened by “real” risks, i.e., during the COVID-19 health crisis. We compared the frequency and engagement of over 348,684 posts published on Facebook between December 2019 and November 2020 by Italian politicians and news media. We identified two waves of  “tangible crisis” assuming that in these two periods the risk stemming from COVID-19 was strongly perceived by the Italian population, contrasting our observations to the periods preceding the first wave and between both waves. Our findings suggest that the political discourse and risk narratives on immigration decreased during times of “tangible crises” for right-wing populist parties and news media. This happened at a time when key policies regarding immigration and regularization of migrants were highly discussed by the Italian government, receiving unexpectedly low reactions. This leads us to theorize that anti-immigrant communication decreases during times of “tangible crises.”
Extracorporeal membrane oxygenation in 34 days old infant with SARS-COV-2 associated pneumonia
Authors: Zhuk Aleh , Tsylko Aliaksei , Nazarava Viktoryia , Migun Anna
Published: April 2023

We present a case of successful veno-arterial extracorporeal membrane oxygenation (VA-ECMO) in infant with SARS-COV-2 associated pneumonia. To the best of our knowledge, this patient was the youngest infant successfully discharged after the VA-ECMO for COVID-19. We report one complication of ECMO support, which was bleeding from the site of the radial artery cannulation. We followed up this patient for 6 months after the discharge: delayed psychomotor development and inability to swallow were noted. Follow-up CT 3 months after the discharge showed linear fibrosis of S5 lung segment.
Validation of models in predicting residual disease in ovarian cancer: comparing CT urography with PET/CT
Authors: Lin Lingling , Liu Qing , Cheng Jiejun , Wang Tingting , Zhou Yan , Song Mengfan , Zhou Bin
Published: April 2023

Background

Many ovarian cancer (OC) residual-disease prediction models were not externally validated after being constructed, the clinical applicability needs to be evaluated.

Purpose

To compare computed tomography urography (CTU) with PET/CT in validating models for predicting residual disease in OC.

Material and Methods

A total of 250 patients were included during 2018–2021. The CTU and PET/CT scans were analyzed, generating CT-Suidan, PET-Suidan, CT-Peking Union Medical College Hospital (PUMC), and PET-PUMC models. All imagings were evaluated by two readers independently, then compared to pathology. According to surgical outcomes, all patients were divided into the R0 group, with no visible residual disease, and the R1 group, with any visible residual disease. Logistic regression was used to assess the discrimination and calibration abilities of each model.

Results

CTU and PET/CT showed good diagnostic performance in predicting OC peritoneal metastases based on the Suidan and PUMC model (all the accuracies >0.8). As for model evaluation, the value of correct classification of the CT-Suidan, PET-Suidan, CT-PUMC, and PET-PUMC models was 0.89, 0.84, 0.88, and 0.83, respectively, representing stable calibration. The areas under the curve (AUC) of these models were 0.95, 0.90, 0.91, and 0.90, respectively. Furthermore, the accuracy of these models at the optimal threshold value (score 3) was 0.75, 0.78, 0.80, and 0.80, respectively. All two-paired comparisons of the AUCs and accuracies did not show a significant difference (all P > 0.05).

Conclusion

CT-Suidan, CT-PUMC, PET-Suidan, and PET-PUMC models had equal abilities in predicting the residual disease of OC. The CT-PUMC model was recommended for its economic and user-friendly characteristics.
An Intervention Program for Male Juvenile Offenders in Turkey: A Pilot Randomized Trial
Authors: Kızıltepe Rukiye , Gümüşten Durdane , Sağel-Çetiner Ece , Ebeoğlu Duman Melisa , Yılmaz Irmak Türkan , Aksel Şeyda
Published: April 2023

Researchers have developed various intervention programs to prevent children from committing crimes and from recidivism; however, few intervention programs have been implemented in juvenile detention centers in Turkey. The aim of this study was to examine the effectiveness of a psychoeducation program to improve the social skills of juvenile offenders. The participants consisted of 38 male adolescents aged 13 to 18 years ( M = 17.02, SD = 1.14) randomly assigned to intervention ( n = 19) and comparison ( n = 19) groups. The results demonstrated that the interaction effects between the group and time were significant for communication and empathy skills. The intervention program prevented declines in empathy skills among program participants, while empathy skills decreased in the comparison group. The participants also improved their communication skills, while comparison group members’ communication skills declined over time. Considering the limited number of intervention programs discussed in the literature, this study provides preliminary support for the literature on intervention programs.
New daily persistent headache: A systematic review and meta-analysis
Authors: Cheema Sanjay , Mehta Dwij , Ray Jason Charles , Hutton Elspeth J , Matharu Manjit Singh
Published: April 2023

Objective

To perform a systematic review and meta-analysis of the epidemiology, precipitants, phenotype, comorbidities, pathophysiology, treatment, and prognosis of primary new daily persistent headache.

Methods

We searched PubMed/Medline, EMBASE, Cochrane, and clinicaltrials.gov until 31 December 2022. We included original research studies with any design with at least five participants with new daily persistent headache. We assessed risk of bias using National Institutes of Health Quality Assessment Tools. We used random-effects meta-analysis where suitable to calculate pooled estimates of proportions. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis compliant study is registered with PROSPERO (registration number CRD42022383561).

Results

Forty-six studies met inclusion criteria, predominantly case series, including 2155 patients. In 67% (95% CI 57–77) of cases new daily persistent headache has a chronic migraine phenotype, however new daily persistent headache has been found to be less likely than chronic migraine to be associated with a family history of headache, have fewer associated migrainous symptoms, be less vulnerable to medication overuse, and respond less well to injectable and neuromodulatory treatments.

Conclusions

New daily persistent headache is a well described, recognisable disorder, which requires further research into its pathophysiology and treatment. There is a lack of high-quality evidence and, until this exists, we recommend continuing to consider new daily persistent headache a distinct disorder.
Physical Dating Violence Victimization among LGBTQ Youth: Disclosure and Association with Mental Health
Authors: Price Myeshia N. , Green Amy E. , DeChants Jonah P. , Davis Carrie K.
Published: April 2023

Youth dating violence and youth suicide are both major public health concerns. However, little research examines the intersection of these issues among lesbian, gay, bisexual, transgender, queer, and questioning (LGBTQ) youth. The current study examined the association between physical dating violence victimization and mental health using online survey data collected from 39,126 LGBTQ youth of ages 13 to 24 in the United States. Overall, 11% of LGBTQ youth who were in a relationship in the past year experienced physical dating violence victimization, with 4% having experienced it once and 7% having experienced it multiple times. Rates of experiencing physical dating violence victimization varied based on a number of youth characteristics and environmental factors. Past-year physical dating violence victimization was associated with nearly four times the odds of attempting suicide in the past year. Given the intersection of suicide risk and dating violence among LGBTQ youth, dating violence prevention organizations must be LGBTQ-inclusive, and suicide prevention must be equipped to address dating violence victimization. The higher rates of physical dating violence victimization among multiple marginalized and socioeconomically disadvantaged LGBTQ youth suggest the need for an intersectional approach that addresses the structural factors that place LGBTQ youth at risk for physical dating violence.
Identifying Protective Factors That Mitigate Relations Between Experiences with Violence and Gun Carriage for Black Young Adults Living in Economically Marginalized Urban Communities
Authors: Walsh Colleen S. , Ross Katherine M. , Bishop Diane L. , Sullivan Terri N.
Published: April 2023

Gun violence disproportionately impacts Black young adults living in economically marginalized urban communities and results in increased risk for injury and death. This study identifies protective factors across the ecological model for Black young adults experiencing peer-based physical and relational aggression and victimization that can mitigate the likelihood of gun carriage. The sample included 141 Black young adults living in economically marginalized communities who had experienced violence. Regression and moderation analyses indicated (1) peer-based physical and relational aggression and victimization negatively associated with gun carriage, and (2) personal assets, positive outlook, student status, and neighborhood attachment interacted with peer-based violent experiences and had protective associations with gun carriage. Findings from this study indicate a need for tailored prevention, policy efforts in order to support Black young adults and decrease gun carriage.
Optimizing the Construction of Outcome Measures for Impact Evaluations of Intimate Partner Violence Prevention Interventions
Authors: Chatterji Sangeeta , Boyer Christopher , Sharma Vandana , Abramsky Tanya , Levtov Ruti , Doyle Kate , Harvey Sheila , Heise Lori
Published: April 2023

Most impact evaluations of intimate partner violence (IPV) prevention interventions use binary measures of “any” versus “no” physical and/or sexual IPV as their primary outcome measure, missing opportunities to capture nuance. In this study, we reanalyzed secondary data from six randomized controlled trials conducted in low- and middle-income countries—Bandebereho (Rwanda), Becoming One (Uganda), Indashyikirwa (Rwanda), MAISHA CRT01, MAISHA CRT02 (Tanzania), Stepping Stones Creating Futures (South Africa), and Unite for a Better Life (Ethiopia), to assess how different conceptualizations and coding of IPV variables can influence interpretations of the impact of an intervention. We compared the standard outcome measures to new measures that reflect the severity and intensity of violence and whether interventions prevent new cases of IPV or reduce or stop ongoing violence. Results indicate that traditional binary indicators masked some of the more subtle intervention effects, and the use of the new indicators allowed for a better understanding of the impacts of the interventions. Conclusions on whether a program is perceived “to work” are highly influenced by the IPV outcomes that the investigators choose to report, and how they are measured and coded. Lack of attention to outcome choice and measurement could lead to prematurely abandoning strategies useful for violence reduction or missing essential insights into how programs may or may not affect IPV. While these results must be interpreted cautiously, given differences in intervention types, the underlying prevalence of violence, sociodemographic factors, sample sizes, and other contextual differences across the trial sites, they can help us move toward a new approach to reporting multiple outcomes that allow us to unpack the “impact” of an intervention by assessing intervention effect by the severity of violence and type of prevention, whether primary and secondary.
Polypropylene based bio-composites for packaging materials: Physico-mechanical impacts of prepared hyper-branched polyamidoamine and gamma-irradiation
Authors: Fathy ES , Ibrahim Saber , Elnaggar Mona Y , Fahmy Hager , Lotfy Salah
Published: April 2023

In an attempt to produce bio-composites that possess good physico-mechanical properties, polyamidoamine (PAMAM) was synthesized and characterized as a multi-nitrogen terminal biocompatible and nontoxic polymeric species. It was mixed at various ratios of 1.0, 2.0, and 3.0% with polypropylene (PP) via Brabender-like apparatus. The prepared bio-composites were exposed to 20 kGy of gamma-irradiation to investigate the influence of ionizing radiation on the fabricated specimens. Parameters of mechanical for instance tensile strength (TS), modulus of elasticity (EM), elongation at break (%), and hardness (Shore D), of bio-composites, were considered. Moreover, the stress-strain curves of the fabricated samples were investigated. Furthermore, FTIR and thermal analysis including TGA and DSC have been investigated. The crystallinity % of all investigated samples was calculated on the basis of DSC measurements. Overall migration of prepared samples has been performed as an applicable study of food packaging. FTIR results revealed the disappearance of the absorption peak at 1730 cm−l of the carbonyl group of polyamidoamine after the formation of PP/PAMAM bio-composites, indicating a successful combination of the PP matrix with polyamidoamine. The incorporation of PAMAM resulted in a steady improvement of the melting temperature (Tm) of the native PP. The thermal stability of PP/PAMAM composition increases with increasing PAMAM and after being exposed to 20 kGy irradiation. Mechanical data revealed that TS of PP increased with PAMAM content up to 3.0%. The development in TS increased from 20 MPa of native PP to 45 MPa of PP/2% PAMAM bio-composites suggesting the superior interaction between the synthetic PAMAM and PP texture. Furthermore, the prepared bio-composite films displayed highly acceptable migration limits.
In-person versus virtual administration of the American College of Rheumatology gold standard cognitive battery in systemic lupus erythematosus: Are they interchangeable?
Authors: Barraclough ML , Diaz-Martinez JP , Knight A , Bingham K , Su J , Kakvan M , Grajales C Muñoz , Tartaglia MC , Ruttan L , Wither J , Choi MY , Bonilla D , Anderson N , Appenzeller S , Parker B , Katz P , Beaton D , Green R , Bruce IN , Touma Z
Published: April 2023

Objective

During the COVID-19 pandemic, many research studies were adapted, including our longitudinal study examining cognitive impairment (CI) in systemic lupus erythematosus (SLE). Cognitive testing was switched from in-person to virtual. This analysis aimed to determine if the administration method (in-person vs. virtual) of the ACR-neuropsychological battery (ACR-NB) affected participant cognitive performance and classification.

Methods

Data from our multi-visit, SLE CI study included demographic, clinical, and psychiatric characteristics, and the modified ACR-NB. Three analyses were undertaken for cognitive performance: (1) all visits, (2) non-CI group visits only and (3) intra-individual comparisons. A retrospective preferences questionnaire was given to participants who completed the ACR-NB both in-person and virtually.

Results

We analysed 328 SLE participants who had 801 visits (696 in-person and 105 virtual). Demographic, clinical, and psychiatric characteristics were comparable except for ethnicity, anxiety and disease-related damage. Across all three comparisons, six tests were consistently statistically significantly different. CI classification changed in 11/71 (15%) participants. 45% of participants preferred the virtual administration method and 33% preferred in-person.

Conclusions

Of the 19 tests in the ACR-NB, we identified one or more problems with eight (42%) tests when moving from in-person to virtual administration. As the use of virtual cognitive testing will likely increase, these issues need to be addressed – potentially by validating a virtual version of the ACR-NB. Until then, caution must be taken when directly comparing virtual to in-person test results. If future studies use a mixed administration approach, this should be accounted for during analysis.
Improved and computationally stable estimation of relative risk regression with one binary exposure
Authors: Pozza Francesco , Kenne Pagui Euloge Clovis , Salvan Alessandra
Published: April 2023

In medical statistics, when the effect of a binary risk factor on a binary response is of interest, relative risk is often the preferred measure due to its direct interpretation. However, statistical inference on this quantity is not as straightforward as for other measures of association, especially when further explanatory variables have to be taken into account. Starting from a review of available methods for inference on relative risk, this paper deals with small and moderate sample size settings for which we show that classical approaches can be problematic. For this reason, we propose the use of improved estimation procedures, aiming at mean or median bias reduction of the maximum likelihood estimator. In particular, these methods are developed for a new alternative specification of a model recently proposed by Richardson et al, where higher computational stability of the estimation methods is achieved. A real-data example and extensive simulation studies show that the proposed methods perform remarkably better than the standard ones.
Synthesis of composites from hydroxypropyl cellulose:iron (III) oxide nanoparticles
Authors: Alharbi Najlaa D
Published: April 2023

In the present work, hydroxypropyl cellulose and hematite (α-Fe2O3) nanoparticles (HPC:Fe2O3NPs) composites in various ratios (20:0.5, 20:1, 20:1.5, and 20:2 wt:wt) were synthesised. X-ray diffraction (XRD), scanning electron microscopy (SEM), FTIR spectroscopy, and thermal analysis (DSC, and TGA) were used to examine the structural configuration and thermal properties of the produced composites. The IR crystallinity indices (TCI, LOI, and HBI) were also computed. XRD patterns reveal a mixture of amorphous HPC polymer components and Fe2O3NPs which identifies the relationship between the characteristics of the structure. Distributions and dispersions of Fe2O3NPs on the surface of HPC are apparent in SEM. FTIR absorbance spectra reveal that as the quantity of Fe2O3NPs increased alterations in the intensity, area, and band width were found indicating a change in the molecular configuration of HPC. Variations in the shape, size, and shifts in melting temperature to higher temperatures were found by DSC and TGA when the amount of Fe2O3NPs is increased which could be due to interactions between HPC and Fe2O3NPs. The antibacterial activity of the nanocomposites was tested against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli bacteria. The composites have good antibacterial activity, confirmed a high potential of antibacterial activity. The findings demonstrated that HPC:Fe2O3NPs composites lead to technological applications in a variety of medical applications.
Nerolidol Attenuates Diabetic Embryopathy in Streptozotocin-induced Diabetic Pregnant Rats by Reducing Embryonic and Maternal Oxidative Stress
Authors: Li Jingjing , Aiyasamy Kalaivani
Published: April 2023

Background

Pregnancy complicated by diabetes leads to congenital disorders, spontaneous abortion, and neonatal morbidity and mortality, which are termed diabetic embryopathy or fetopathy.

Objectives

In this work, we planned to investigate the therapeutic potentials of nerolidol against streptozotocin (STZ)-induced diabetic embryopathy in rats through attenuating maternal and fetal oxidative stress.

Materials and Methods

The male and female Wistar rats were allowed to mate for a night at a 1:1 ratio. After the confirmation of pregnancy, the rats were administered 40 mg/kg of STZ (i.p.) to initiate diabetes and treated with 20 and 40 mg/kg of nerolidol. The changes in food intake, body weight, blood glucose, and urine output were regularly monitored. The levels of lipid profiles were estimated using assay kits. The oxidative stress and antioxidant biomarkers in the liver tissues and embryonic fractions were measured using assay kits.

Results

The nerolidol treatment considerably depleted the blood glucose and urine output and augmented the body weight and diet intake in diabetic rats. The nerolidol suppressed the cholesterol (Ch), triglycerides (TG), and very low density lipoprotein (VLDL) and elevated the high density lipoprotein (HDL) level in diabetic pregnant rats. The maternal and embryonic oxidative stress levels are effectively reduced by the nerolidol treatment by decreasing the malondialdehyde (MDA) and reactive oxygen species (ROS) levels. The levels of antioxidants were also increased by the nerolidol on both liver and embryonic fractions of diabetic pregnant rats.

Conclusion

Our results exhibited that the nerolidol treatment considerably reduced embryonic and maternal oxidative stress and embryonic deaths. Hence, it can be a hopeful therapeutic candidate to treat diabetic embryopathy.
GEDEFO-SEFH management of antineoplastic extravasations survey results
Authors: Jiménez-Pulido Inmaculada , Albert-Marí María Asunción , Conde-Estévez David , San José-Ruiz Begoña , Gil-Lemus María Ángeles , Cercós-LLetí Ana Cristina , Esteban-Mensua María Jesús , Díaz-Carrasco María Sacramento
Published: April 2023

Introduction

Extravasation is a potentially severe complication of intravenous administration of antineoplastic drugs. The limited data makes it difficult to develop an optimal management scheme. The objective of this study is to describe the clinical practice in the extravasation management of antineoplastic agents in Spanish centers.

Methods

An online survey was distributed to oncology pharmacists using the email distribution list of the Spanish Society of Hospital Pharmacists. Respondents were surveyed on the standard operational protocol (SOP) of extravasation, tissue damage risk classification, and specific measures of extravasation management.

Results

A total of 68 surveys were completed. A specific extravasation SOP was available in 82.4% centers. The pharmacist participates in the authorship (100%) and actively collaborates in extravasation management (76.5%). A tissue damage risk classification based on the three categories was mostly adopted (48.2%) and 73.2% applied specific criteria based on concentration and/or extravasated volume. Extravasation management was mainly performed with the application of physical measures and/or antidotes (91.2%). High variability in the choices of pharmacological and/or physical measures recommended is outstanding.

Conclusion

The results of this study highlight the involvement of Spanish pharmacists in extravasation management, the application of physical measures and/or pharmacological measures as the method of choice in extravasation management, as well as the existing discrepancies in tissue damage risk classification and management recommendations
Practice-based and public-deliberative normativity: retaining human control over the use of force
Authors: Bode Ingvild
Published: April 2023

The debate about lethal autonomous weapons systems (LAWS) characterises them as future problems in need of pre-emptive regulation, for example, through codifying meaningful human control. But autonomous technologies are already part of weapons and have shaped how states think about human control. To understand this normative space, I proceed in two steps: first, I theorise how practices of designing, of training personnel for, and of operating weapon systems integrating autonomous technologies have shaped normativity/normality on human control at sites unseen. Second, I trace how this normativity/normality interacts with public deliberations at the Group of Governmental Experts (GGE) on LAWS by theorising potential dynamics of interaction. I find that the normativity/normality emerging from practices performed in relation to weapon systems integrating autonomous technologies assigns humans a reduced role in specific use of force decisions and understands this diminished decision-making capacity as ‘appropriate’ and ‘normal’. In the public-deliberative process, stakeholders have interacted with this normativity by ignoring it, engaging in distancing or positively acknowledging it – rather than scrutinising it. These arguments move beyond prioritising public deliberation in norm research towards exploring practices performed at sites outside of the public eye as productive of normativity. I theorise this process via international practice theories, critical security studies and Science and Technology scholarship to draw out how practices shape normativity, presenting ideas of oughtness and justice, and normality, making something appear normal via collective, repeated performances.
The myth of spirituality
Authors: Taylor Edward H
Published: April 2023

This article is designed to open a conversation about the place of spirituality in social work, highlight possible ethical issues, and question whether spirituality, as defined by social work and popular culture, is an immutable part of human development. Additionally, the role of social work in conducting spiritual assessments and interventions is specifically challenged, along with examples of how the misuse of spirituality can harm clients. The article also suggests that the profession would benefit from adopting an evidence-based concept of spirituality and establishing accountability standards. Findings: Until more is known about spirituality, social workers may want to consider: (1) placing a moratorium on using and developing spiritual assessment instruments until the concept can be accurately defined; (2) omitting words linked to religious symbols such as soul, anointing, blessing, etc. in social work practice; (3) conducting spiritual screenings rather than complete spiritual assessments, and (4) referring clients with spiritual questions or wanting spiritual support to experts known not to blame or harm clients and trained in the specific area of concerns expressed by the person. Applications. The time has come for social work to establish ethics, accountability, and limitations on the practice of spirituality.
Dating Apps: A New Emerging Platform for Sexual Harassment? A Scoping Review
Authors: Gewirtz-Meydan Ateret , Volman-Pampanel Denise , Opuda Eugenia , Tarshish Noam
Published: April 2023

Currently, dating apps are one of the most popular platforms for meeting romantic and sexual partners. However, little is known about the potential for sexual harassment on these platforms. In the current scoping review, we sought to examine what is known about sexual harassment facilitated through smartphone dating apps. We searched for studies that reported on sexual harassment via dating apps through PubMed, Web of Science, PsycInfo, Communication Abstracts, Sociological Abstracts, and IEEE Xplore databases. Twelve studies addressed the risk of sexual harassment on dating apps. We found that sexual harassment when using dating apps is prevalent and ranges between 57 and 88.8%, with two populations being at higher risk: women and individuals who identify as a sexual minority. In terms of forms of harassment, sexual harassment via dating apps can take place online (e.g., being sent unsolicited images, or “dick pics”) or offline (e.g., a face-to-face meeting that was arranged on a dating app). Experiencing sexual harassment on dating apps is associated with higher levels of depression, anxiety, post-traumatic stress disorder, loneliness, early childhood maltreatment, less perceived self-control, and lower self-esteem. Some studies suggest that experiencing sexual harassment on dating apps reflects social structures and appears differently in different groups (e.g., among sexual minorities). More research is needed to capture the prevalence of adult sexual harassment via the use of dating apps, the different forms of harassment, risk and protective factors, and social and cultural structures that facilitate this kind of sexual harassment.
Psycho-Social Experiences and Healthcare Delivery for Older Adults in Nigeria
Authors: Nnadi Helen Chinedu , Ezeh Peter Jazzy
Published: April 2023

Each country is expected to take care of its growing population. In Nigeria, the pre-requisite for adequate health care delivery are still unmet. Nigerians especially the elderly fall victim to the danger of death. The study seeks to explore psycho-social experiences and healthcare delivery for older adults in Nigeria. Quantitative and qualitative methods were used for data collection from 1,180 respondents, from seven villages in the community. Data were analyzed using content analysis, simple percentages, and chi-square. The study found that there is no healthcare delivery for the elderly, they underwent problems such as loneliness, isolation, and abandonment in healthcare delivery. The study recommends the intervention of the government which will enhance the conditions of the elderly.