bluuebunny/crossref_metadata_2025 huggingface dataset:
Minimally invasive removal of deep contraceptive implants under continuous ultrasound guidance is effective, quick, and safe
Authors: Jacques Thibaut , Brienne Charlotte , Henry Simon , Baffet Hortense , Giraudet Géraldine , Demondion Xavier , Cotten Anne
Published: October 2021

Objectives

The aim of this study was to assess the feasibility, performance, and complications of a non-surgical, minimally-invasive procedure of deep contraceptive implant removal under continuous ultrasound guidance.

Methods

The ultrasound-guided procedure consisted of local anesthesia using lidocaine chlorhydrate 1% (10 mg/mL) with a 21-G needle, followed by hydrodissection using NaCl 0.9% (9 mg/mL) and implant extraction using a Hartmann grasping microforceps. The parameters studied were the implant localization, success and complication rates, pain throughout the intervention, volumes of lidocaïne and NaCl used, duration of the procedure, and size of the incision. Between November 2019 and January 2021, 45 patients were referred to the musculoskeletal radiology department for ultrasound-guided removal of a deep contraceptive implant and were all retrospectively included.

Results

All implants were successfully removed en bloc (100%). The mean incision size was 2.7 ± 0.5 mm. The mean duration of the extraction procedure was 7.7 ± 6.3 min. There were no major complications (infection, nerve, or vessel damage). As a minor complication, 21 patients (46.7%) reported a benign superficial skin ecchymosis at the puncture site, spontaneously regressing in less than 1 week. The procedure was very well-tolerated, with low pain rating throughout (1.0 ± 1.5/10 during implant extraction).

Conclusions

Minimally invasive removal of deep contraceptive implants under continuous ultrasound guidance alone is feasible, effective, and safe. In the present cohort, all implants were successfully removed, whatever the location, with short procedural time, small incision size, low pain levels, and no significant complications. This procedure could become a gold standard in this indication.

Key Points

• Minimally invasive removal of deep contraceptive implants under continuous ultrasound guidance alone is feasible, which led to a success rate of 100% whatever the location (even close to neurovascular structures), with only a small skin incision (2.7 ± 0.5 mm).

• The procedure was safe, quick, without any major complications, and very well tolerated in terms of pain.

• This minimally invasive ultrasound-guided procedure could become the future gold standard for the removal of deep contraceptive implants, as an alternative to surgical extraction, even for implants in difficult locations such as subfascial ones or those close to neurovascular structures.
Distance mathematics teaching in Flanders, Germany, and the Netherlands during COVID-19 lockdown
Authors: Drijvers Paul , Thurm Daniel , Vandervieren Ellen , Klinger Marcel , Moons Filip , van der Ree Heleen , Mol Amy , Barzel Bärbel , Doorman Michiel
Published: October 2021

The COVID-19 pandemic has confronted mathematics teachers with the challenge of developing alternative teaching practices—in many cases at a distance through digital technology—because schools were closed. To investigate what distance practices in secondary mathematics education have emerged and how teachers experienced them, we set out online questionnaires in Flanders—the Dutch-speaking part of Belgium—, Germany, and the Netherlands. The questionnaire focused on teaching practices, teacher beliefs, didactics, and assessment. Data consisted of completed questionnaires by 1719 mathematics teachers. Results show that the use of video conferencing tools increased massively, while the use of mathematics-specific tools that teachers used before the lockdown reduced substantially. Further findings are that teachers' confidence in using digital technologies increased remarkably during the lockdown and that their experiences and beliefs only marginally impacted their distance learning practices. Also, we observed some differences between the three countries that might be explained by differences in educational policies and in technological facilities and support. For future research, it would be relevant to investigate long-term changes in teachers’ practices, as well as students’ views and experiences related to the teacher’s practices.
Fracture surface formation of notched 2017A-T4 aluminium alloy under bending fatigue
Authors: Macek Wojciech
Published: October 2021

The effect of cyclic loading on facture surface topology in notched components made by aluminium alloys is not completely clear. Fractography and fracture mechanics can help to understand this interdependency. This paper aims to study the distribution of the fracture surface roughness of notched 2017A-T4 aluminium alloy after bending fatigue using an optical focus-variation surface measurement technique by applying the fracture zone concept. The effects of stress level at the notch root and the load ratio on fatigue crack growth and fracture surfaces are analysed. Profile and areal surface parameters of four fracture surface regions were investigated at incremental crack lengths of the specimens. Studies have confirmed that the surface areas associated with the main stages of fatigue phenomenon (i.e. crack initiation, crack propagation, and final rupture) have significant differences in roughness which can be explained by the different loading scenarios. Overall, fatigue fracture surfaces have smallest roughness values at the crack initiation stage and a gradual increase during the fatigue crack growth stage.
Electrical and mechanical behaviour of metal thin films with deformation-induced cracks predicted by computational homogenisation
Authors: Kaiser T. , Cordill M. J. , Kirchlechner C. , Menzel A.
Published: October 2021

Motivated by advances in flexible electronic technologies and by the endeavour to develop non-destructive testing methods, this article analyses the capability of computational multiscale formulations to predict the influence of microscale cracks on effective macroscopic electrical and mechanical material properties. To this end, thin metal films under mechanical load are experimentally analysed by using in-situ confocal laser scanning microscopy (CLSM) and in-situ four point probe resistance measurements. Image processing techniques are then used to generate representative volume elements from the laser intensity images. These discrete representations of the crack pattern at the microscale serve as the basis for the calculation of effective macroscopic electrical conductivity and mechanical stiffness tensors by means of computational homogenisation approaches. A comparison of simulation results with experimental electrical resistance measurements and a detailed study of fundamental numerical properties demonstrates the applicability of the proposed approach. In particular, the (numerical) errors that are induced by the representative volume element size and by the finite element discretisation are studied, and the influence of the filter that is used in the generation process of the representative volume element is analysed.
Influence of irradiance on the growth and biochemical composition of Nitzschia aff. pellucida
Authors: Lisondro Isaac , Gómez Serrano Cintia , Sepúlveda Claudia , Batista Ceballos Ariadna Indira , Acién Fernández Francisco Gabriel
Published: October 2021

In this paper the influence of irradiance and the operation modes on biomass production and biochemical composition, especially the fatty acid profile, on the diatom Nitzschia aff. pellucida was studied. Experiments were carried out under laboratory conditions, but simulating those outdoors, at irradiances ranging from 100 to 1000 µmol photons m−2 s−1, both in batch and semi-continuous mode. The data show that the growth rate increased with irradiance, following a hyperbolic relationship with the average irradiance (Eav). However, at irradiances higher than 450 µmol photons m−2 s−1, photo-inhibition was observed, with Fv/Fm values notably decreasing at irradiances above 1000 µmol photons m−2 s−1. To take account of this phenomenon, a growth model is proposed that considers the saturation constant modification (Ek) as a function of available irradiance. The data indicate that N. aff. pellucida is better adapted to low irradiances, below 300 µmol photons m−2 s−1. Regarding the biochemical composition, the highest content of lipids (~ 20%) and carbohydrates (~ 40%) was achieved at high irradiances (≥ 450 µmol photons m−2 s−1), while the highest protein content (> 8%) was found at low irradiances (≤ 200 µmol photons m−2 s−1). Elevated amounts of saturated fatty acids (SFA) (> 60%) were measured at high irradiances, while the highest content of unsaturated fatty acids (USFA) (> 35%) was found at low irradiances. Eicosapentaenoic acid (C20:5 n-3) (EPA) and arachidonic acid (C20:4 n-6) (ARA) were only detected at 200 µmol m−2 s−1 but not at higher irradiances. The results confirm the effects of irradiance and the cultivation mode on the growth and biochemical composition of N. aff. pellucida. The model is an important tool when using this valuable strain to produce compounds of biological interest.
RB-CCR: Radial-Based Combined Cleaning and Resampling algorithm for imbalanced data classification
Authors: Koziarski Michał , Bellinger Colin , Woźniak Michał
Published: October 2021

Real-world classification domains, such as medicine, health and safety, and finance, often exhibit imbalanced class priors and have asynchronous misclassification costs. In such cases, the classification model must achieve a high recall without significantly impacting precision. Resampling the training data is the standard approach to improving classification performance on imbalanced binary data. However, the state-of-the-art methods ignore the local joint distribution of the data or correct it as a post-processing step. This can causes sub-optimal shifts in the training distribution, particularly when the target data distribution is complex. In this paper, we propose Radial-Based Combined Cleaning and Resampling (RB-CCR). RB-CCR utilizes the concept of class potential to refine the energy-based resampling approach of CCR. In particular, RB-CCR exploits the class potential to accurately locate sub-regions of the data-space for synthetic oversampling. The category sub-region for oversampling can be specified as an input parameter to meet domain-specific needs or be automatically selected via cross-validation. Our $$5\times 2$$

5
×
2

cross-validated results on 57 benchmark binary datasets with 9 classifiers show that RB-CCR achieves a better precision-recall trade-off than CCR and generally out-performs the state-of-the-art resampling methods in terms of AUC and G-mean.
RNA sequencing of LX-2 cells treated with TGF-β1 identifies genes associated with hepatic stellate cell activation
Authors: Carson Jack P. , Robinson Mark W. , Ramm Grant A. , Gobert Geoffrey N.
Published: October 2021

Background

Hepatic stellate cells (HSCs) are liver-resident myofibroblast precursors responsible for the production of collagen and maintenance of the hepatic extracellular matrix (ECM). As such, they are generally associated with fibrotic liver diseases. HSCs become “activated” in response to tissue damage or pathogen invasion, a process most commonly driven by transforming growth factor-β1 (TGF-β1). Despite this, the full extent of TGF-β1 signalling in these cells is poorly understood. Clarifying the range and diversity of this signalling will further improve our understanding of the process of HSC activation.

Methods and results

RNA sequencing was used to quantitate the transcriptomic changes induced in LX-2 cells, an activated human HSC line, following TGF-b1 treatment. In total, 5,258 genes were found to be significantly differentially expressed with a false discovery rate cut-off of < 0.1. The topmost deregulated of these genes included those with no currently characterised role in either HSC activation or fibrotic processes, including CIITA and SERPINB2. In silico analysis revealed the prominent signalling pathways downstream of TGF-β1 in LX-2 cells.

Conclusions

In this study, we describe the genes and signalling pathways significantly deregulated in LX-2 cells following TGF-β1 treatment. We identified several highly deregulated genes with no currently characterised role in HSC activation, which may represent novel mediators of fibrotic responses in HSCs or the liver macroenvironment. This work may be of use in the identification of new markers of liver fibrosis and could provide insight into prospective genes or pathways that might be targeted for the amelioration of fibrotic liver disease in the future.
What is a social pattern? Rethinking a central social science term
Authors: Mondani Hernan , Swedberg Richard
Published: October 2021

The main aim of this article is to start a discussion of social pattern, a term that is commonly used in sociology but not specified or defined. The key question can be phrased as follows: Is it possible to transform the notion of social pattern from its current status in sociology as a proto-concept into a fully worked out concept? And if so, how can this be done? To provide material for the discussion we begin by introducing a few different types of patterns that are currently being used (patterns in nature, cultural patterns, statistical patterns, and computationally generated patterns). This is followed by a suggestion for what a strictly sociological concept of social pattern may look like. A useful and theoretically solid concept of social pattern can in our view be constructed by basing it on Weber’s concept of social action. This means that both the behavior of the actors and the meaning these invest their behavior with must be taken into account. The article ends with a brief discussion of how to use the concept of social patterns in an effective way and what may endanger such a use.
Phosphorus Losses to Surface Runoff Waters After Application of Digestate to a Soil Over Fertilised with Phosphorus
Authors: Horta Carmo , Carneiro João Paulo
Published: October 2021

Anaerobic digestates from biogas plants can be used as agricultural fertilisers providing recycling nitrogen (N) and other nutrients for crop needs. It is still unclear the impact on phosphorus (P) losses to runoff waters of digestates as sources of N instead of inorganic N fertilisers in over fertilised soils with P. A field experiment was done in a sandy and acidic soil high in P. The experimental design was completely randomised with five treatments. The inorganic N fertilisation (90 kg ha−1) was done in four treatments, those with past P inputs of the following: (i) inorganic N and P fertilisers (Ni/MF), (ii) organic amendments (pig or duck dry slurry-Ni/PS and Ni/DS or cattle manure compost-Ni/CM). Digestate was applied in plots with past P input of cattle slurry (DG/CS) providing also 90 kg N ha−1. Ryegrass was sowed as cover crop. The concentration of total dissolved P in runoff waters was high in all treatments and ranged between 0.5 (Ni/PS) and 2.6 mg L−1 (DG/CS). These runoff waters pose a risk of non-source P pollution for fresh waters. In soils with low P sorption capacity and over fertilised with P, the fertilisation with anaerobic digestate as the only source of N to crops increased the risk of P losses to runoff waters compared with inorganic N fertilisation. Therefore, the amount of digestate applied to soil must be calculated considering its N:P ratio in order to not exceed the crop P requirement.
Dancing with the sound in edge computing environments
Authors: Hao Wangli , Han Meng , Li Shancang , Li Fuzhong
Published: October 2021

Conventional motion predictions have achieved promising performance. However, the length of the predicted motion sequences of most literatures are short, and the rhythm of the generated pose sequence has rarely been explored. To pursue high quality, rhythmic, and long-term pose sequence prediction, this paper explores a novel dancing with the sound task, which is appealing and challenging in computer vision field. To tackle this problem, a novel model is proposed, which takes the sound as an indicator input and outputs the dancing pose sequence. Specifically, our model is based on the variational autoencoder (VAE) framework, which encodes the continuity and rhythm of the sound information into the hidden space to generate a coherent, diverse, rhythmic and long-term pose video. Extensive experiments validated the effectiveness of audio cues in the generation of dancing pose sequences. Concurrently, a novel dataset of audiovisual multimodal sequence generation has been released to promote the development of this field.
Improved Discrimination of Tumors with Low and Heterogeneous EGFR Expression in Fluorescence-Guided Surgery Through Paired-Agent Protocols
Authors: Wang Cheng , Xu Xiaochun , Folaron Margaret , Gunn Jason R. , Hodge Sassan , Chen Eunice Y. , Hoopes P. Jack , Tichauer Kenneth M. , Samkoe Kimberley S.
Published: October 2021

Purpose

The goal of fluorescence-guided surgery (FGS) in oncology is to improve the surgical therapeutic index by enhancing contrast between cancerous and healthy tissues. However, optimal discrimination between these tissues is complicated by the nonspecific uptake and retention of molecular targeted agents and the variance of fluorescence signal. Paired-agent imaging (PAI) employs co-administration of an untargeted imaging agent with a molecular targeted agent, providing a normalization factor to minimize nonspecific and varied signals. The resulting measured binding potential is quantitative and equivalent to in vivo immunohistochemistry of the target protein. This study demonstrates that PAI improves the accuracy of tumor-to-healthy tissue discrimination compared to single-agent imaging for in vivo FGS.

Procedures

PAI using a fluorescent anti-epidermal growth factor receptor (EGFR) affibody molecule (ABY-029, eIND 122,681) with untargeted IRDye 700DX carboxylate was compared to ABY-029 alone in an oral squamous cell carcinoma xenograft mouse model at 3 h after dye administration (n = 30).

Results

PAI significantly enhanced tumor discrimination, as compared to ABY-029 alone in low EGFR-expressing tumors and highly heterogeneous populations including multiple cell lines with varying expression (diagnostic accuracy: 0.908 vs. 0.854 and 0.908 vs. 0.822; and ROC curve AUC: 0.963 vs. 0.909 and 0.957 vs. 0.909, respectively) indicating a potential for universal FGS image thresholds to determine surgical margins. In addition, PAI achieved significantly higher diagnostic ability than ABY-029 alone 0.25–5-h post injection and exhibited a stronger correlation to EGFR expression heterogeneity.

Conclusion

The quantitative receptor delineation of PAI promises to improve the surgical therapeutic index of cancer resection in a clinically relevant timeline.
Assessing glyphosate in water, marine particulate matter, and sediments in the Lagoon of Venice
Authors: Feltracco Matteo , Barbaro Elena , Morabito Elisa , Zangrando Roberta , Piazza Rossano , Barbante Carlo , Gambaro Andrea
Published: October 2021

Lagoon water, suspended particulate matter, and sediment samples from seven sites at Lagoon of Venice were collected from 2019 to 2021 in order to study the presence of the herbicide glyphosate (N-(phosphonomethyl)glycine), among the most widely used agricultural chemicals worldwide, but its occurrence in lagoon water environment has not been deeply investigated. The sites were selected considering a supposed diversity of inputs and of pollution levels. An analytical method based on ion chromatography coupled with tandem mass spectrometry was optimized and validated for lagoon water, marine particulate matter, and sediment samples. Maximum concentrations of glyphosate were 260 and 7 ng L−1 for lagoon water and suspended particulate matter, respectively, and 15 ng g−1 for sediment, with some spatial and temporal fluctuations. Our results demonstrate that glyphosate content in the Venice Lagoon mainly depends on external forcing from river inlets and agricultural lagoon activities.
Analyzing the contributions of transdisciplinary research to the global sustainability agenda in African cities
Authors: Thiam Sokhna , Aziz Fati , Kushitor Sandra Boatemaa , Amaka-Otchere Akosua Baah Kwarteng , Onyima Blessing Nonye , Odume Oghenekaro Nelson
Published: October 2021

It is almost 6 years since the UN’s Sustainable Development Goals (SDGs) were adopted, and countries have less than 10 years to achieve the set targets. Unlike most of the world, sub-Saharan African countries have reported only minimal progress, one that the COVID-19 pandemic has unfortunately disrupted. Transdisciplinary research (TDR) has been conceptualized as important for achieving sustainability goals such as the SDGs. In this paper we (i) analyze the contributions of the five TDR projects toward the achievements of the SDGs at the city level in Africa, and (ii) explore the interactions between the assessed SDGs across the five projects. The projects’ contributions towards the achievements of the SDGs were examined in three thematic areas: (i) contexts, (ii) processes and (iii) products. The five projects were funded under the Leading Integrated Research for Agenda 2030 in Africa (LIRA) programme. The projects were being implemented in nine cities across five African countries Accra (Ghana), Kumasi (Ghana), Korhogo (Ivory Coast), Abuja Metro (Nigeria), Mbour (Senegal), Cape Town (South Africa), Nelson Mandela Bay Metro (South Africa), Grahamstown (South Africa) and Kampala (Uganda) and data were collected on each of the five projects in these cities. The contextual contributions include co-analysis and reflection on policy and institutional silos and social innovations amenable to contextual complexity. A shift in how actors perceived and conceptualized sustainability challenges and the role of the projects as transformative social agents constituted the two main process contributions. Tool development, virtual models and maps, and handbook are the product contributions by the projects. Our analysis of the SDG interactions indicated the need for cross-sectoral collaborations to ensures resource use efficiency, knowledge and experience sharing, and seamless flow of information and data to accelerate the SDG implementation.
Requirements of a cognitive-motor spatial orientation training for nursing home residents: an iterative feasibility study
Authors: Fricke Madeleine , Kruse Adele , Schwenk Michael , Jansen Carl-Philipp , Muehlbauer Thomas , Gramann Klaus , Wollesen Bettina
Published: October 2021

A sedentary lifestyle in nursing home residents is often accompanied with reduced life space mobility and in turn affects satisfaction with life. One of the reasons for this may be limited ability to find one’s way around the care facility and its environment. However, spatial orientation exercises might reduce these problems if they are integrated into an adequate cognitive-motor training. Therefore, we integrated six novel and target group-specific spatial orientation exercises into an established multicomponent cognitive-motor group training for nursing home residents and evaluated its feasibility. Forty nursing home residents (mean age: 87.3 ± 7 years) participated in the spatial orientation cognitive motor training (45–60 min, twice a week over a period of 12 weeks). The main outcomes included the feasibility criteria (adherence, completion time, acceptance, instructions, motor performance, materials/set up, complexity) and first measurements of mobility and satisfaction with life (SPPB [Short Physical Performance Battery], SWLS [Satisfaction with Life Scale]). Adherence increased over time. The increase was associated with the adaptions and modifications of the spatial orientation exercises that were made to meet the participants’ requirements. A positive trend was discerned for mobility and life satisfaction, comparing pre- and posttraining data. In summary, the feasibility analysis revealed that future interventions should consider that (a) instructions of demanding spatial tasks should be accompanied by an example task, (b) trainers should be encouraged to adjust task complexity and materials on an individual basis, (c) acceptance of the training should be promoted among nursing staff, and (d) surroundings with as little disturbance as possible should be selected for training.
The TCI Clinical Encounter Program for PhD Students in Cancer Biology: a Feasibility Pilot
Authors: Real Alexander M. , Lin Jenny J. , Gabrilove Janice L.
Published: October 2021

Clinical rotations are often not included in graduate-level cancer biology curricula; however, basic insight into clinical oncology is often crucial for developing translational research that addresses unmet needs with the potential to benefit cancer patients. We describe a needs assessment, design, implementation, and descriptive evaluation of an oncology-specific pilot clinical encounter program developed for PhD students in the Cancer Biology Training Area (CAB) in the Graduate School of Biomedical Sciences (GSBS) and Tisch Cancer Institute (TCI) at the Icahn School of Medicine at Mount Sinai (ISMMS). Prior to the development of this pilot program, CAB students, in years 2–5 + , were surveyed to determine their interest in a structured clinical experience. Seventeen out of thirty-one students responded (55%) to the survey. Of those seventeen respondents, fifteen (88.2%) expressed that exposure to cancer patients in the clinical setting would be useful for their pre-doctoral biomedical science and cancer biology training and indicated an interest in participating in the clinical encounter program. Based on these responses, a three-session clinical encounter pilot program was designed. Two separate cohorts of 5 students participated in this pilot program. During a formal debrief, following the clinical experience, students commented on the resilience of patients and the importance of research on clinical decision making, and reported that they found the experience motivational. Five out of 10 students responded (50%) to a post-program assessment survey; all five respondents answered that they would recommend the clinical encounter program to their peers. While limited in size and scope, this pilot TCI Clinical Encounter Program proved feasible and has the potential to enrich and inform the experience of PhD students pursing advanced degrees in a cancer biology.
Hegel's Century
Authors: Stewart Jon
Published: October 2021

The remarkable lectures that Hegel gave in Berlin in the 1820s generated an exciting intellectual atmosphere which lasted for decades. From the 1830s, many students flocked to Berlin to study with people who had studied with Hegel, and both his original students, such as Feuerbach and Bauer, and later arrivals including Kierkegaard, Engels, Bakunin, and Marx, evolved into leading nineteenth-century thinkers. Jon Stewart's panoramic study of Hegel's deep influence upon the nineteenth century in turn reveals what that century contributed to the wider history of philosophy. It shows how Hegel's notions of 'alienation' and 'recognition' became the central motifs for the era's thinking; how these concepts spilled over into other fields – like religion, politics, literature, and drama; and how they created a cultural phenomenon so rich and pervasive that it can truly be called 'Hegel's century.' This book is required reading for historians of ideas as well as of philosophy.
Hostages and Human Rights
Authors: Galani Sofia
Published: October 2021

Hostage-taking has increased in recent years and has become a problem of worldwide concern. Terrorists and pirates have used hostages in a rising number of incidents and the violence used has escalated alarmingly. Sofia Galani examines the taking of hostages from a victim's perspective, arguing that the international community has failed to protect them. By evaluating various international law concepts and frameworks, including jurisdiction in international law, state responsibility and international human rights law, Galani explains why we are still far from recognizing hostages as victims of human rights violations. She then addresses the question of what can be done to safeguard the human rights of hostages both in theory and practice. Being the first comprehensive study of the human rights of hostages, this book fills a critical gap in the literature for human rights lawyers and researchers in the field.
The Black Voices in Research curriculum to promote diversity and inclusive excellence in biomedical research
Authors: Levites Strekalova Yulia A. , Qin Yufan Sunny , Sharma Shubam , Nicholas Justine , McCaslin Gailine P. , Forman Kristina E. , Long Denise B. , Pineda Tiffany Danielle , Williams Taylor K. , Kolb H. Robert
Published: October 2021

Underrepresentation of Black biomedical researchers demonstrates continued racial inequity and lack of diversity in the field. The Black Voices in Research curriculum was designed to provide effective instructional materials that showcase inclusive excellence, facilitate the dialog about diversity and inclusion in biomedical research, enhance critical thinking and reflection, integrate diverse visions and worldviews, and ignite action. Instructional materials consist of short videos and discussion prompts featuring Black biomedical research faculty and professionals. Pilot evaluation of instructional content showed that individual stories promoted information relevance, increased knowledge, and created behavioral intention to promote diversity and inclusive excellence in biomedical research.
Mindfulness-Oriented Recovery Enhancement remediates anhedonia in chronic opioid use by enhancing neurophysiological responses during savoring of natural rewards
Authors: Garland Eric L. , Fix Spencer T. , Hudak Justin P. , Bernat Edward M. , Nakamura Yoshio , Hanley Adam W. , Donaldson Gary W. , Marchand William R. , Froeliger Brett
Published: October 2021

Background

Neuropsychopharmacologic effects of long-term opioid therapy (LTOT) in the context of chronic pain may result in subjective anhedonia coupled with decreased attention to natural rewards. Yet, there are no known efficacious treatments for anhedonia and reward deficits associated with chronic opioid use. Mindfulness-Oriented Recovery Enhancement (MORE), a novel behavioral intervention combining training in mindfulness with savoring of natural rewards, may hold promise for treating anhedonia in LTOT.

Methods

Veterans receiving LTOT (N = 63) for chronic pain were randomized to 8 weeks of MORE or a supportive group (SG) psychotherapy control. Before and after the 8-week treatment groups, we assessed the effects of MORE on the late positive potential (LPP) of the electroencephalogram and skin conductance level (SCL) during viewing and up-regulating responses (i.e. savoring) to natural reward cues. We then examined whether these neurophysiological effects were associated with reductions in subjective anhedonia by 4-month follow-up.

Results

Patients treated with MORE demonstrated significantly increased LPP and SCL to natural reward cues and greater decreases in subjective anhedonia relative to those in the SG. The effect of MORE on reducing anhedonia was statistically mediated by increases in LPP response during savoring.

Conclusions

MORE enhances motivated attention to natural reward cues among chronic pain patients on LTOT, as evidenced by increased electrocortical and sympathetic nervous system responses. Given neurophysiological evidence of clinical target engagement, MORE may be an efficacious treatment for anhedonia among chronic opioid users, people with chronic pain, and those at risk for opioid use disorder.
Plasma acetyl-l-carnitine and l-carnitine in major depressive episodes: a case–control study before and after treatment
Authors: Ait Tayeb Abd El Kader , Colle Romain , El-Asmar Khalil , Chappell Kenneth , Acquaviva-Bourdain Cécile , David Denis J. , Trabado Séverine , Chanson Philippe , Feve Bruno , Becquemont Laurent , Verstuyft Céline , Corruble Emmanuelle
Published: October 2021

Background

Major depressive disorder (MDD) is the main cause of disability worldwide, its outcome is poor, and its underlying mechanisms deserve a better understanding. Recently, peripheral acetyl-l-carnitine (ALC) has been shown to be lower in patients with major depressive episodes (MDEs) than in controls. l-Carnitine is involved in mitochondrial function and ALC is its short-chain acetyl-ester. Our first aim was to compare the plasma levels of l-carnitine and ALC, and the l-carnitine/ALC ratio in patients with a current MDE and healthy controls (HCs). Our second aim was to assess their changes after antidepressant treatment.

Methods

l-Carnitine and ALC levels and the carnitine/ALC ratio were measured in 460 patients with an MDE in a context of MDD and in 893 HCs. Depressed patients were re-assessed after 3 and 6 months of antidepressant treatment for biology and clinical outcome.

Results

As compared to HC, depressed patients had lower ALC levels (p < 0.00001), higher l-carnitine levels (p < 0.00001) and higher l-carnitine/ALC ratios (p < 0.00001). ALC levels increased [coefficient: 0.18; 95% confidence interval (CI) 0.12–0.24; p < 0.00001], and l-carnitine levels (coefficient: −0.58; 95% CI −0.75 to −0.41; p < 0.00001) and l-carnitine/ALC ratios (coefficient: −0.41; 95% CI −0.47 to −0.34; p < 0.00001), decreased after treatment. These parameters were completely restored after 6 months of antidepressant. Moreover, the baseline l-carnitine/ALC ratio predicted remission after 3 months of treatment (odds ratio = 1.14; 95% CI 1.03–1.27; p = 0.015).

Conclusions

Our data suggest a decreased mitochondrial metabolism of l-carnitine into ALC during MDE. This decreased mitochondrial metabolism is restored after a 6-month antidepressant treatment. Moreover, the magnitude of mitochondrial dysfunction may predict remission after 3 months of antidepressant treatment. New strategies targeting mitochondria should be explored to improve treatments of MDD.
Influencers in design teams: a computational framework to study their impact on idea generation
Authors: Singh Harshika , Cascini Gaetano , McComb Christopher
Published: October 2021

It is known that wherever there is human interaction, there is social influence. Here, we refer to more influential individuals as “influencers”, who drive team processes for better or worst. Social influence gives rise to social learning, the propensity of humans to mimic the most influential individuals. As individual learning is affected by the presence of an influencer, so is an individual's idea generation . Examining this phenomenon through a series of human studies would require an enormous amount of time to study both individual and team behaviors that affect design outcomes. Hence, this paper provides an agent-based approach to study the effect of influencers during idea generation. This model is supported by the results of two empirical experiments which validate the assumptions and sustain the logic implemented in the model. The results of the model simulation make it possible to examine the impact of influencers on design outcomes, assessed in the form of exploration of design solution space and quality of the solution. The results show that teams with a few prominent influencers generate solutions with limited diversity. Moreover, during idea generation, the behavior of the teams with uniform distribution of influence is regulated by their team members' self-efficacy.
The relationship between religious beliefs and mental state, care burden, and quality of life in parents of infant patients with congenital heart disease
Authors: Liu Jian-Feng , Xie Wen-Peng , Lei Yu-Qing , Cao Hua , Chen Qiang
Published: October 2021

Objective:

To evaluate the relationship between religious beliefs and mental state, care burden, and quality of life in parents of infantile patients with CHD.

Methods:

A cross-sectional study was conducted at a provincial hospital in Fujian, China. In this study, 114 parents of infant patients with CHD were successfully enrolled. Data were collected using the Duke University Religion Index, Hospital Anxiety and Depression Scale, Zarit Caregiver Burden Interview, and 36-Item Short-Form Health Survey.

Results:

The organisational religious activity, non-organisational religious activity, and intrinsic religiosity of parents were significantly related to the care burden and quality of life, and the two dimensions of non-organisational religious activity and intrinsic religiosity of parents were significantly related to their anxiety symptoms. No association was found between parents’ religious beliefs and their depressive symptoms. Among Buddhist parents, non-organisational religious activity and intrinsic religiosity reduced the care burden and improved quality of life. Among Christian parents, organisational religious activity and non-organisational religious activity were found to reduce the care burden, while organisational religious activity and intrinsic religiosity were found to improve quality of life. There was no correlation between the sub-dimensions of religious beliefs and a negative impact on the care process in Muslim parents.

Conclusion:

Religious beliefs have a protective effect on the parents of infant patients with CHD. They help relieve parents’ anxiety, reduce their care burden, and improve their quality of life. In addition, different religious beliefs have different dimensions of influence on caregivers.
Racial Limitations on the Gender, Risk, Religion, and Politics Model
Authors: Friesen Amanda , Holman Mirya R.
Published: October 2021

Risk aversion dampens political participation and heightens religiosity, with concentrated effects among women. Yet, little is known about how intersecting identities moderate these psychological correlates of religiosity and political engagement. In this paper, we theorize that the risk-religion-politics relationship is gendered and racialized. Using a nationally representative survey, we show that political participation is more strongly correlated with risk for Black women than for any other race-gender group. For religiosity, however, we find little evidence that risk is related to religiosity among Black women, while highly correlated with white women's religious engagement. For men—whether Black or white—risk exhibits a modest, positive relationship with their religiosity. Our results speak to the importance of considering intersectionality and race-gender identities in evaluations of religious and political activities in the United States.
A side-edge frame dual-band eight-element MIMO antenna array for 5G handset
Authors: Zabetiakmal Mahsa , Moradi Gholamreza , Ghorbani Ayaz
Published: October 2021

In this paper, a dual-band 8 × 8 multi-input multi-output (MIMO) array antenna operating in 3.5 GHz band (3400–3600 MHz) and 5.5 GHz band (5150–5925 MHz) for 5G mobile handset is presented. The proposed hybrid antenna includes a comb-shaped monopole and an L-shaped open slot antenna which are symmetrically located on the inner surface of the side-edge frame of smartphone. Pattern diversity is achieved that can mitigate envelope correlation coefficients (ECCs) and improve the MIMO system performances. The prototype of proposed dual-band eight-element MIMO antenna is fabricated and experimentally measured. The results show that isolation <−10 and <−15 dB, respectively in the lower band and high band without any additional decoupling element are achieved and the desired bands are satisfied under the condition of −6 dB impedance matching. Moreover, the essential parameters for evaluation of the MIMO system performance such as the ECC, mean effective gain (MEG), and ergodic channel capacity are calculated. Furthermore, the influence of user's hand on the radiation characteristics of proposed MIMO antenna are also investigated and discussed. Based on the result, the proposed MIMO antenna is a good candidate for use in future 5G applications.
The quest for a miniaturized antenna in the wireless capsule endoscopy application: a review
Authors: Gayen Sreetama , Biswas Balaka , Karmakar Ayan
Published: October 2021

This review paper explores the potential use of the planar miniaturized antenna for wireless capsule endoscopy application: one of the promising fields in the current era. The paper highlights the design strategy, various optimization techniques with respect to system realization, material compatibility issues and finally the mandatory EM radiation effect analysis for the said application. It compares amongst various currently reported structures in context with different performance metrics. Inherent challenges of this emerging field of bio-medical engineering have also been detailed here along with futuristic approaches for enhancing the throughput.
Fault Interactions Enhance High‐Frequency Earthquake Radiation
Authors: Chu Shanna X. , Tsai Victor C. , Trugman Daniel T. , Hirth Greg
Published: October 2021

Fault complexity has been linked to high‐frequency earthquake radiation, although the underlying physical mechanisms are not well understood. Fault complexity is commonly modeled with rough single faults; however, real‐world faults are additionally complex, existing within networks of other faults. In this study, we introduce two new ways of defining fault complexity using mapped fault traces, characterizing fault networks in terms of their degree of alignment and density. We find that both misalignment and density correlate with enhanced high‐frequency seismic radiation across Southern California, with misalignment showing a stronger correlation. This robust correlation suggests that high‐frequency radiation may arise in part from fault‐fault interactions within networks of misaligned faults. Fault‐fault interactions may therefore have important consequences for earthquake rupture dynamics, energetics and earthquake hazards and should not be overlooked.
Targeting the complex I and III of mitochondrial electron transport chain as a potentially viable option in liver cancer management
Authors: Yang Qin , Wang Ling , Liu Jiaye , Cao Wanlu , Pan Qiuwei , Li Meng
Published: October 2021

Liver cancer is one of the most common and lethal types of oncological disease in the world, with limited treatment options. New treatment modalities are desperately needed, but their development is hampered by a lack of insight into the underlying molecular mechanisms of disease. It is clear that metabolic reprogramming in mitochondrial function is intimately linked to the liver cancer process, prompting the possibility to explore mitochondrial biochemistry as a potential therapeutic target. Here we report that depletion of mitochondrial DNA, pharmacologic inhibition of mitochondrial electron transport chain (mETC) complex I/complex III, or genetic of mETC complex I restricts cancer cell growth and clonogenicity in various preclinical models of liver cancer, including cell lines, mouse liver organoids, and murine xenografts. The restriction is linked to the production of reactive oxygen species, apoptosis induction and reduced ATP generation. As a result, our findings suggest that the mETC compartment of mitochondria could be a potential therapeutic target in liver cancer.
Opposite response of blood vessels in the retina to 6° head-down tilt and long-duration microgravity
Authors: Taibbi Giovanni , Young Millennia , Vyas Ruchi J. , Murray Matthew C. , Lim Shiyin , Predovic Marina , Jacobs Nicole M. , Askin Kayleigh N. , Mason Sara S. , Zanello Susana B. , Vizzeri Gianmarco , Theriot Corey A. , Parsons-Wingerter Patricia
Published: October 2021

The Spaceflight Associated Neuro-ocular Syndrome (SANS), associated with the headward fluid shifts incurred in microgravity during long-duration missions, remains a high-priority health and performance risk for human space exploration. To help characterize the pathophysiology of SANS, NASA’s VESsel GENeration Analysis (VESGEN) software was used to map and quantify vascular adaptations in the retina before and after 70 days of bed rest at 6-degree Head-Down Tilt (HDT), a well-studied microgravity analog. Results were compared to the retinal vascular response of astronauts following 6-month missions to the International Space Station (ISS). By mixed effects modeling, the trends of vascular response were opposite. Vascular density decreased significantly in the 16 retinas of eight astronauts and in contrast, increased slightly in the ten retinas of five subjects after HDT (although with limited significance). The one astronaut retina diagnosed with SANS displayed the greatest vascular loss. Results suggest that microgravity is a major variable in the retinal mediation of fluid shifts that is not reproduced in this HDT bed rest model.
Simple security proofs for continuous variable quantum key distribution with intensity fluctuating sources
Authors: Li Chenyang , Qian Li , Lo Hoi-Kwong
Published: October 2021

Despite tremendous theoretical and experimental progress in continuous variable (CV) quantum key distribution (QKD), the security has not been rigorously established for most current continuous variable quantum key distribution systems that have imperfections. Among these imperfections, intensity fluctuation is one of the principal problems affecting security. In this paper, we provide simple security proofs for continuous variable quantum key distribution systems with intensity fluctuating sources. Specifically, depending on device assumptions in the source, the imperfect systems are divided into two general cases for security proofs. In the most conservative case, we prove the security based on the tagging idea, which is a main technique for the security proof of discrete variable quantum key distribution. Our proofs are simple to implement without any hardware adjustment for current continuous variable quantum key distribution systems. Also, we show that our proofs are able to provide secure secret keys in the finite-size scenario.
Automatic identification of triple negative breast cancer in ultrasonography using a deep convolutional neural network
Authors: Ye Heng , Hang Jing , Zhang Meimei , Chen Xiaowei , Ye Xinhua , Chen Jie , Zhang Weixin , Xu Di , Zhang Dong
Published: October 2021

Triple negative (TN) breast cancer is a subtype of breast cancer which is difficult for early detection and the prognosis is poor. In this paper, 910 benign and 934 malignant (110 TN and 824 NTN) B-mode breast ultrasound images were collected. A Resnet50 deep convolutional neural network was fine-tuned. The results showed that the averaged area under the receiver operating characteristic curve (AUC) of discriminating malignant from benign ones were 0.9789 (benign vs. TN), 0.9689 (benign vs. NTN). To discriminate TN from NTN breast cancer, the AUC was 0.9000, the accuracy was 88.89%, the sensitivity was 87.5%, and the specificity was 90.00%. It showed that the computer-aided system based on DCNN is expected to be a promising noninvasive clinical tool for ultrasound diagnosis of TN breast cancer.