bluuebunny/crossref_metadata_2025 huggingface dataset:
Screening of a Large Cohort of Asymptomatic SDHx Mutation Carriers in Routine Practice
Authors: Saie Clotilde , Buffet Alexandre , Abeillon Juliette , Drui Delphine , Leboulleux Sophie , Bertherat Jérôme , Zenaty Delphine , Storey Caroline , Borson-Chazot Françoise , Burnichon Nelly , Vincent Marie , Favier Judith , Baudin Eric , Giraud Sophie , Gimenez-Roqueplo Anne-Paule , Amar Laurence , Lussey-Lepoutre Charlotte
Published: November 2020

Context

When an SDHx mutation is identified in a patient with a pheochromocytoma (PCC) or a paraganglioma (PGL), predictive genetic testing can detect mutation carriers that would benefit from screening protocols.

Objective

To define the tumor detection rate in a large cohort of asymptomatic SDHX mutation carriers.

Design and Setting

Retrospective multicentric study in 6 referral centers.

Patients

Between 2005 and 2019, 249 asymptomatic SDHx (171 SDHB, 31 SDHC, 47 SDHD) mutation carriers, with at least 1 imaging work-up were enrolled.

Results

Initial work-up, including anatomical (98% of subjects [97–100% according to center]) and/or functional imaging (67% [14–90%]) detected 48 tumors in 40 patients. After a negative initial work-up, 124 patients benefited from 1 to 9 subsequent follow-up assessments (mean: 1.9 per patient), with a median follow-up time of 5 (1–13) years. Anatomical (86% [49–100 %]) and/or functional imaging (36% [7–60 %]) identified 10 new tumors (mean size: 16 mm [4–50]) in 10 patients. Altogether, 58 tumors (55 paraganglioma [PGL], including 45 head and neck PGL, 2 pheochromocytoma [PCC], 1 gastrointestinal stromal tumor [GIST]), were detected in 50 patients (22 [13%] SDHB, 1 [3.2%] SDHC, and 27 [57%] SDHD), with a median age of 41 years old [11–86], 76% without catecholamine secretion and 80% during initial imaging work-up.

Conclusions

Imaging screening enabled detection of tumors in 20% of asymptomatic SDHx mutation carriers, with a higher detection rate in SDHD (57%) than in SDHB (13%) and SDHC (3%) mutation carriers, arguing for a gene-by-gene approach. Prospective studies using well-defined protocols are needed to obtain strong and useful data.
Do GLP-1 Receptor Agonists Increase the Risk of Breast Cancer? A Systematic Review and Meta-analysis
Authors: Piccoli Giovana F , Mesquita Leonardo A , Stein Cinara , Aziz Marina , Zoldan Maira , Degobi Nathália A H , Spiazzi Bernardo F , Lopes Junior Gilberto L , Colpani Verônica , Gerchman Fernando
Published: November 2020

Context

Risk of cancer is a major concern in the development of drugs for the treatment of obesity and diabetes. In randomized controlled trials (RCTs) of the Liraglutide Clinical Development Program, subjects treated with a glucagon-like peptide-1 receptor agonist (GLP-1RA) had a higher absolute number of breast cancer events.

Objective

To assess whether patients treated with GLP-1RAs had a higher risk of breast neoplasms.

Data Sources

We searched MEDLINE, Embase, Web of Science, and CENTRAL from July 31, 2019 to February 8, 2020.

Study Selection

Reviewers assessed abstracts and full-text articles for RCTs of GLP-1RAs in adults with excessive weight and/or diabetes and a minimum follow-up of 24 weeks.

Data Extraction

Researchers extracted study-level data and assessed within-study risk of bias with the RoB 2.0 tool and quality of evidence with Grading of Recommendations Assessment, Development and Evaluation (GRADE).

Data Synthesis

We included 52 trials, of which 50 reported breast cancer events and 11 reported benign breast neoplasms. Overall methodological quality was high. Among 48 267 subjects treated with GLP-1RAs, 130 developed breast cancer compared with 107 of 40 755 controls (relative risk [RR], 0.98; 95% confidence interval [CI], 0.76–1.26). Subset analyses according to follow-up, participant/investigator blinding, and type of GLP-1RA did not reveal any differences. The risk of benign breast neoplasms also did not differ between groups (RR, 0.99; 95% CI, 0.48–2.01). Trial sequential analysis provided evidence that the sample size was sufficient to avoid missing alternative results.

Conclusions

Treatment with GLP-1RAs for obesity and diabetes does not increase the risk of breast neoplasms.
An unusual cause of obstructive jaundice: Lemmel’s syndrome
Authors: Bellamlih Habib , Echchikhi Meryem , El Farouki Aymane , Moatassim Billah Nabil , Nassar Ittimade
Published: December 2020

Lemmel’s syndrome is a rare and misdiagnosed cause of obstructive jaundice. The cause of the obstacle is a duodenal diverticulum located at the periampullary generating a compression effect on the common bile duct with secondary dilation of the extra- and intra-hepatic bile ducts. Late diagnosis of this entity is common and may lead to unnecessary further investigations and therapeutic delay. There are only few case reports of this rare condition. We report a case of 77-year-old female presenting with obstructive jaundice due to Lemmel’s syndrome. The diagnosis was made on a set of clinical, biological and radiological arguments with good improvement after medical treatment.
Young carers: ‘You are not alone’
Authors: Abbott-Mitchell Laura
Published: November 2020

It is essential that professionals working with children and young people meet the needs of young carers, and that young carers themselves know that they are not alone and that help is available to them. In this article, Laura Abbott-Mitchell shares her story as a young carer, her struggles and advice to others.
Uso de una matriz autóloga en el tratamiento de úlceras de pie diabético, con espectroscopia de infrarrojo cercano y medidor de pH dérmico
Authors: Vallejo Leticia , Achterberg Jean
Published: November 2020

Objetivo:

Evaluar la eficacia de una matriz autóloga en el tratamiento de úlceras de pie diabético (UPD) de difícil cicatrización, y analizar la respuesta inmune a la aplicación de la matriz con un escáner de infrarrojo cercano (NIRS, por sus siglas en inglés) y un medidor de pH dérmico.

Método:

Tres pacientes fueron tratados con una matriz de coágulo de sangre completa (WBC, por sus siglas en inglés) autóloga. La matriz se realizó en el punto de atención, mezclando la sangre del paciente con una suspensión coloidal de gluconato de calcio/caolín, e inyectándola en una bandeja de coagulación. Se formó un gel de WBC y se aplicó a las heridas. El gel de WBC se mantuvo en su lugar con apósitos primarios y secundarios.

Resultados:

Hubo una reducción del tamaño de las UPD de 70% tras dos aplicaciones, 97,6% después de tres aplicaciones, y 90,9% tras cuatro aplicaciones. El NIRS midió un aumento en la saturación de oxígeno tisular. No hubo reacciones adversas.

Conclusión:

La matriz autóloga fue eficaz en el tratamiento de las UPD. La superficie de las UPD se redujo después de cada aplicación y se logró el cierre completo de las heridas. Se necesitan más ensayos clínicos para comprender mejor los beneficios de la matriz de WBC en UPD.

Conflicto de interés:

RedDress Ltd. (Pardes-Hanna, Israel) proporcionó los suministros y materiales del estudio. Bennett Health Inc. ayudó con el desarrollo del protocolo y capacitó al personal sobre la aplicación del producto para coágulos sanguíneos. JA es accionista de Bennett Health Inc. No hubo interés financiero para ninguno de los investigadores o participantes.
Casos de pioderma gangrenoso en pacientes con quemaduras: revisión de la literatura
Authors: Gaviria-Castellanos Jorge Luis , Cardozo Alexander Carvajal , Rubiano Andrea del Pilar Cruz
Published: November 2020

Objetivo:

Realizar una revisión de la literatura de casos de pioderma gangrenoso (PG) asociados con quemaduras, y comparar los resultados con un caso clínico de PG en un paciente con quemaduras, presentado por los autores en este mismo artículo.

Método:

Se revisó la literatura en las bases de datos PubMed, ScienceDirect y ClinicalKey, entre junio de 2006 y julio de 2020. De los 831 artículos encontrados, sólo 43 cumplieron con los criterios de inclusión. Nueve artículos, con 17 casos de estudio, fueron seleccionados. Se evaluó, además, el caso de estudio realizado por los autores (C18).

Resultados:

De los 18 casos totales, 50% fue mujer y, el restante 50%, hombre. En el 55% de los casos, las zonas con lesiones más afectadas fueron las del miembro inferior. El tratamiento más frecuentemente empleado fue con corticoides, en 88,9% de los casos. Hubo similitudes entre los casos estudiados.

Conclusión:

En lesiones traumáticas, como las quemaduras, el PG se presenta mayoritariamente en áreas sanas, ya cicatrizadas. Ocurre, con frecuencia, en los miembros inferiores, pero puede aparecer en cualquier área anatómica. Se presenta a cualquier edad, incluso en menores de edad, con mayor frecuencia en la quinta década de la vida.

Conflicto de interés:

Ninguno.
Cinco complicaciones comunes en heridas quirúrgicas: prevención y manejo
Authors: Freire Juan Francisco Benalcázar
Published: November 2020

Sinopsis:

El 3 de septiembre de 2020, durante la conferencia virtual Semana HEI (heridas, estomas e incontinencias), el cirujano vascular Juan Francisco Benalcázar Freire, del Hospital de Especialidades de las Fuerzas Armadas en Quito, Ecuador, presentó un webinar que describió las complicaciones más frecuentes en heridas quirúrgicas. En este reporte, el Dr Benalcázar resume los puntos más relevantes de su ponencia y alienta a los profesionales de la salud a enfocarse no sólo en la profilaxis de la infección del sitio quirúrgico, sino también en los cinco problemas más comunes de la herida quirúrgica.

Conflicto de interés:

JFBF ha trabajado como presentador en conferencias organizadas o auspiciadas por Essity.
Ultra-narrowband perfect absorption of monolayer two-dimensional materials enabled by all-dielectric subwavelength gratings
Authors: Nie Jiaqiang , Yu Jiancan , Liu Wenxing , Yu Tianbao , Gao Pingqi
Published: November 2020

Monolayer two-dimensional materials (2DMs) have excellent optical and electrical properties and show great application potential in photodetectors. However, the thickness at the atomic scale leads to weak light absorption, which greatly limits the responsivity of corresponding photodetectors. Here we propose an all-dielectric sub-wavelength zero-contrast grating structure that enables a monolayer of MoS2 with ultra-narrow bandwidth perfect light absorption. The absorption enhancement can be attributed to the critical coupling of guided mode resonances from two specific order diffractions in the structure, as confirmed by the planar waveguide theory and coupled mode theory. Such absorption enhancement can be generalized to any other absorptive atomically thin films, and the wavelength of perfect absorption can be tuned by scaling the dimension of the photonic structure. Our results offer a promising photonic approach to realize ultra-highly sensitive narrow-band photodetectors by using atomically thin materials.
Effects of differing withdrawal times from ractopamine hydrochloride on residue concentrations of beef muscle, adipose tissue, rendered tallow, and large intestine
Authors: Davis Haley E. , Geornaras Ifigenia , Lindstrom Valerie , Chaparro Jacqueline M. , Nair Mahesh N. , Delmore Robert J. , Engle Terry E. , Belk Keith E. , Prenni Jessica E.
Published: December 2020

Ractopamine hydrochloride (RAC) is a beta-agonist approved by the U.S. Food and Drug Administration (FDA) as a medicated feed ingredient for cattle during the final days of finishing to improve feed efficiency and growth. Maximum residue limits and U.S. FDA residue tolerances for target tissues have defined management practices around RAC usage in the U.S. However, many countries have adopted zero tolerance policies and testing of off-target tissues, presenting a major challenge for international export. Therefore, the objective this study was to determine the necessary withdrawal time among cattle group-fed RAC to achieve residue concentrations below tolerance levels in muscle and off-target tissues. Specifically, both total and parent RAC residues were quantified in muscle, adipose tissue, rendered tallow, and large intestines from animals group-fed RAC and subjected to withdrawal 2, 4, or 7 days before harvest. Ractopamine (parent and total) residues were below the assay limit of detection (< 0.12 ng/g) in all muscle and adipose tissue samples from animals in control groups (no RAC). However, RAC residues were detectable, but below the limit of quantitation, in 40% of tallow and 17% of large intestine samples from control animals. As expected, mean RAC residue concentrations in muscle, adipose tissue, and large intestine samples decreased (P< 0.05) as the RAC withdrawal duration (days) was extended. Irrespective of RAC withdrawal duration, mean parent RAC residue concentrations in muscle, adipose tissue, and large intestine ranged from 0.33 to 0.76 ng/g, 0.16 to 0.26 ng/g, 3.97 to 7.44 ng/g, respectively and all tallow samples were > 0.14 ng/g (detectable but below the limit of quantitation). Results of this study provide a baseline for the development of management protocol recommendations associated with withdrawal following group-feeding of RAC to beef cattle in countries that allow RAC use and intend to export to global markets which may be subject to zero tolerance policies and off-target tissue testing.
Trajetória e implementação de Disciplina Interprofissional para cursos da Área de Saúde
Authors: Miguel Edson Arpini , Bicudo Angélica Maria , Albiero Adriana Meyer , Alves Rozilda Neves , Rocha Najara
Published: December 2020

Introdução: Na Educação Interprofissional duas ou mais profissões de saúde aprendem uma sobre a outra, aprimorando atitudes, conhecimento, habilidades e comportamentos para a prática colaborativa. Na Universidade Estadual de Maringá (UEM) os cursos de saúde apresentam currículos com disciplinas, hierarquizados e centrados no professor. Justificam- se mudanças em busca de uma formação integral. Objetivo: Este trabalho descreve a criação e implementação de disciplinas interprofissionais que atuam na Atenção Primária em Saúde (APS). Método: Os componentes curriculares denominados Atenção em Saúde I e II foram introduzidos, de forma obrigatória, na matriz curricular nos cursos de Medicina, Enfermagem, Odontologia, Farmácia, Educação Física, Biomedicina e Psicologia. O total de estudantes matriculados é de aproximadamente 440 por ano, com 42 professores/tutores vinculados às disciplinas. Nas atividades é utilizada problematização, conforme tutorial previamente construído pelos docente e profissionais dos serviços. Resultados: Os estudantes  em  grupos, pelo menos um de cada curso, tem como cenários de ensino a rede APS. O total de alunos que cumpriram a disciplina está em torno de 1500 com 140 projetos de intervenção executados. A avaliação formativa é composta de eixos cognitivos, psicomotor e afetivo, articulados, contínuos e sistemáticos. Conclusão: a inovação da interprofissionalidade na graduação na primeira série dos cursos tem proporcionado maior integração entre os estudantes e realização de práticas colaborativas, além da aproximação da universidade com os serviços de saúde.
“I, humble servant of your grace”: Isabel de Salazar’s and Ana de Nabarrete’s Petitions
Authors: Silva Yamile
Published: November 2020

This essay analyzes two seventeenth-century unpublished letters of women’s authorship sent to the Spanish monarchy. I argue in this essay that the letters of Doña Isabel de Salazar (1611) and Doña Ana de Nabarrete (1621) are two textual representations facilitated by their ability to utilize the bureaucracy and demonstrate the authors’ exercise of power and inscribe them within a legal, bureaucratic, and hierarchical instrument—culturally, socially, and ultimately, economically. Salazar and Nabarrete perform a textual agency by means of transactions and negotiations within a specific power structure.
Imaginar ciudades: A Concrete Individual, an Imagined Community
Authors: García Ana Cruz
Published: November 2020

This article examines how the reality of gender is sensed and subsequently written in María Luisa Puga’s novel Inventar ciudades to ascertain how gender differences can be perceived and ultimately how the author’s hostile positioning towards feminist literature can be understood. The protagonist’s identity, Licha, resides in her ability to see, hear and touch reality in order to write about it and ultimately understand it. But can this focus on the individual lead to the disintegration of the communal? This article also explores how Licha actively participates in a community to which new meanings can be attached through the senses and writing.
Identidade materna e as grades da prisão
Authors: Sydney de Sousa Albertina Antonielly , Marculino Guerreiro Barbosa Eryjosy , Gomes Cezário Roscoche Kariane , Azevedo Queiroz Ana Beatriz , De Melo Fialho Ana Virgínia , Paiva Rodrigues Dafne
Published: November 2020

A estrutura do sistema carcerário foi erguida sobre pilares masculinos, o que reflete na invisibilidade de peculiaridades femininas como o exercício da maternagem, tanto em relação ao filho nascido no ambiente prisional quanto aos filhos que ficaram fora do cárcere. Objetivou-se descrever o fenômeno da maternagem dividida entre 14 detentas que viviam com os filhos no berçário de uma penitenciária de Aquiraz, Ceará, por meio de entrevistas em profundidade e observação simples/participante.

PALAVRAS-CHAVE: Mães. Prisões. Privação Materna. Relações Mãe-Filho. Poder Familiar.
As opressões antinaturais sofridas pelas mulheres
Authors: Blaudt Vanessa Lima , Rangel Mary , Caetano Marcio
Published: November 2020

Neste texto, o objetivo é o de dialogar com as perspectivas teóricas do feminismo materialista francês, iniciadas durante a década de 1970, clarificando a opressão da classe das mulheres – intencionalmente operada e, sob a (falsa) designação da natureza, justificada.

Palavras-chave: Teoria Feminista. Feminismo Materialista. Opressão Material. Classes de Sexo.
Entrevista de Lia Zanotta Machado
Authors: Machado Lia Zanotta , Pastana Debora Regina , Souza Márcio Ferreira de
Published: November 2020

Lia Zanotta Machado é Doutora em Ciências Humanas (Sociologia) pela Universidade de São Paulo (1980), com graduação em Ciências Sociais pela Universidade de São Paulo (1967), mestrado em Sociologia pela Universidade de São Paulo (1979) e pós-doutorado (CNPq) no Institut de Recherches sur les Sociétés Contemporaines (IRESCO) e na École des Hautes Etudes en Sciences Sociales (EHESS), Paris (1992-1994). Professora Titular de Antropologia da Universidade de Brasília desde 1996, é atualmente Pesquisadora Colaboradora Sênior desde 2014.
“Zhenshchina mozhet vse!”, sim, senhores!
Authors: Ribeiro do Prado Vanessa
Published: November 2020

A presente resenha pretende analisar e, ao mesmo tempo, apresentar às leitoras e leitores a recente tradução para o português da obra "Una donna può tutto. 1941: volano le Streghe della notte" (no original), da jornalista e escritora italiana Ritanna Armeni. No Brasil, o livro recebeu o título de "As Bruxas da Noite: a história não contada do regimento aéreo russo na Segunda Guerra Mundial", e foi editada e publicada pela Editora Seoman, do Grupo Editorial Pensamento. Para além do cenário bélico, a obra aborda temáticas de gênero, como misoginia e sororidade.
Mulheres em situação de violência
Authors: Menta Sandra Aiache
Published: November 2020

O objetivo desse artigo é apresentar uma análise do comportamento de mulheres em situação de violência e suas estratégias de empoderamento psicológico problematizando-a sob a perspectiva da Teoria de Autodeterminação.

PALAVRAS-CHAVE: Autodeterminação. Violência. Empoderamento Psicológico.
O feminicídio como expressão de poder nas relações de gênero
Authors: Moreira Hélio Luiz Fonseca , Moreira Iriscélia Acácio
Published: November 2020

O estudo teve como principal objetivo, abordar o feminicídio como expressão de poder nas relações de gênero, em um contexto social atravessado pelos elevados índices de violência contra à mulher, cuja expressão mais brutal se materializa na banalização do feminicídio. Trata-se de uma pesquisa qualitativa, em matiz transdisciplinar, particularmente, o jurídico e o sociológico, fundada em diversas fontes de evidência, cujas principais foram a pesquisa bibliográfica, e o levantamento de dados correlatos à violência contra à a mulher. A violência e a distribuição desigual do poder na relação entre gêneros serão analisadas com base nas contribuições teóricas elaboradas por Bourdieu (1989, 2003). O estudo evidenciou que, no Brasil, os altos índices de violência, a criminalização secundária e a degradação identitária são fatores que geram insegurança e indignidade às mulheres.

PALAVRAS-CHAVE: Violência. Mulher. Feminicídio.
Prostituição, migrações sexuais e tráfico de pessoas para fins de exploração sexual
Authors: Garcia Danler
Published: November 2020

O escopo deste trabalho é compreender como a categoria da vulnerabilidade é compreendida por três normativas concernentes ao enfrentamento do tráfico de pessoas, principalmente quando para fins de exploração sexual. A hipótese deste trabalho é a de que a vulnerabilidade muito mais estorva as migrações livres e consentidas daquelas que aspiram trafegar nos mercados transnacionais do sexo do que aufere proteção às mesmas.

PALAVRAS-CHAVE: Mercados Sexuais. Migrações Sexuais. Tráfico Sexual. Vulnerabilidade.
Ação penal pública incondicionada nos crimes contra a liberdade sexual
Authors: Ferreira Silva Luiza
Published: November 2020

O artigo objetiva situar o fenômeno do simbolismo penal e sua relação com a alteração legislativa referente à ação penal nos crimes contra a liberdade sexual. Com isso, busca-se compreender como tal medida distancia-se de uma visibilidade real às mulheres vítimas de violência sexual, no sentido de fortalecer sua autonomia e participação decisória no processo.

PALAVRAS-CHAVE: Crimes Contra a Liberdade Sexual. Ação Penal Pública Incondicionada. Simbolismo Penal.
Coerção e consentimento no crime de estupro
Authors: Silva Leite Mariana , Camargo Beatriz  Corrêa , Freitas Lima Marília
Published: November 2020

A presente pesquisa tem por objetivo analisar a questão do consentimento da vítima para a caracterização do crime de estupro no Brasil. Isso será feito a partir de uma reflexão sobre a disputa de narrativas no campo jurídico brasileiro. Assim, este estudo se ocupa, primeiramente, das discussões mais recentes acerca do conceito de consentimento no Direito Penal Sexual em âmbito internacional. Em seguida, apresenta-se um panorama sobre o crime de estupro no direito brasileiro, fazendo o contraponto com algumas decisões colhidas na jurisprudência. Ao fim, conclui-se sobre a exigência da resistência da vítima como resquício simbólico de um discurso patriarcal, que nega sobretudo à mulher a autonomia de decisão sobre a própria sexualidade.

PALAVRAS-CHAVE: Consentimento. Estupro. Campo Jurídico. Gênero. Crimes Sexuais.
Synthesis and Structure of Aryl Phosphorus Compounds
Authors:   South Ural State University, Zykova A.
Published: November 2020

Based on an analysis of the literature published from the late 20th century to the beginning of the 21st century, methods for the synthesis of some complex tetraorganylphosphonium salts are systematized and described, along with the features of the chemical transformations of pentaphenylphosphorus, which was first obtained in 1953. The tetraorganylphosphonium salts were known much earlier, however, the features of the synthesis of transition metal complexes, which are usually obtained from tetraorganylphosphorus halides and metal halides, have not been sufficiently studied. The present review is devoted to the discussion of these topics, since the famous Wittig Reaction is associated with aryl phosphorus compounds, which allows synthesizing alkenes of a given structure, and derivatives of transition metals rightfully occupy a special place among catalysts of various chemical processes. The continuation of these classical studies in the field of chemistry of organoelemental compounds takes place at one of the leading universities in Russia - South Ural State University in the laboratory of chemistry of organoelemental compounds at the Faculty of Chemistry. This article aims at familiarizing the reader with the achievements of Professor V.V. Sharutin and his students in the field of organophosphorus compounds. The main attention is paid to the reactions of pentaphenylphosphorus and its derivatives, as well as methods for the synthesis of ionic complexes of silver, gold, copper, titanium, zirconium, hafnium, ruthenium, osmium, cobalt, rhodium, iridium, palladium and platinum with tetraorganylphosphonium cations. The structural features of the described compounds and the possibility of using transition metal complexes in some catalytic reactions are described.
Synthesis, Structure and Properties of Zn0.3Ni0.7–xCoxFe2O4 (x = 0–0.6) Ferrite.
Authors:   South Ural State University, Sherstyuk D. , Starikov A. , Zhivulin V. , Zherebtsov D. , Vinnik D. ,   South Ural State Humanitarian Pedagogical University
Published: November 2020

For many years, Ni-Zn ferrites with the spinel structure have actively been used as various components for RF devices. An analysis of modern scientific literature has been carried out, as a result of which an alloying element has been determined that will change the complex of physicochemical properties of the initial matrix of Ni-Zn ferrite. The article presents the results of a study of the Zn0.3Ni0.7–xCoxFe2O4 ferrite, where x takes the value 0–0.6 in increments of 0.2. In addition to the alloying element, the properties of the samples under study are affected by selection of the method of obtaining the material, as well as the temperature-time mode of synthesis. The samples have been obtained by the solid-phase synthesis in a tube furnace with silicon carbide heaters at a temperature of 1150 °C for 5 hours of isothermal exposure. The objective of the present study is to obtain new compositions of nickel-zinc ferrite doped by cobalt according to the already known technology for a wider concentration range, as well as investigate their properties. The chemical composition has been analyzed on a Jeol JSM 7001F scanning electron microscope equipped with an Oxford INCA X-max 80 X-ray dispersion spectrometer to determine the actual gross formula of sintered samples, the results of which are in good agreement with the theoretical given formulas. As a result of X-ray phase analysis (RigakuUltima IV), it has been found that all the samples under study are monophasic and have the spinel structure with an Fd-3m space group. Unit cell parameters monotonically increase with increasing cobalt concentration x (Co) (from 8.3643 (4) Å to 8.3983 (4) Å). As a result of the study of DSC curves (Netzsch, STA 449 F1 Jupiter), it has been found that partial replacement of Ni and Zn ions by cobalt ions leads to a decrease in the Curie temperature (from 341 °C to 419 °C). Since ferrite parts are used at various temperature conditions, such alloying makes it possible to effectively control the range of working temperatures of the material.
WESTERN AND ISLAMIC VALUES AND ETHICS: ARE THEY DIFFERENT?
Authors: Haron Hasnah , Jamil Nurul Nazlia , Ramli Nathasa Mazna
Published: November 2020

Values are fundamental paradigms that shape attitudes and guide behaviour of human. Values shape morals, where morals help in shaping ethics. The first objective of this paper is to reviews values and ethics based on western and Islamic perspectives. The second objective specifically compares western and Islamic values. For comparison purposes, western values are represented by Schwartz values, while Islamic values are based on a study from Ghoniyah and Hartono (2014) and Ebrahimi and Yusoff (2017). Quran and Sunnah were referred to in highlighting the difference between the western and Islamic values. The analysis is done based on four dimensions, namely self-enhancement, openness to change, self-transcendence and conservation. The study finds that there are a lot of similarities between western and Islamic values. Both values have the same intention of nurturing better mankind.  However, there are two western values, namely “Power” and “Hedonism” that has no direct link with Islamic values. This is because, in Islam, Muslims believe that only Allah SWT has the ultimate will and power over life and death. Besides that, Islam encourages the attitude of promoting mashlahah rather than focusing on worldly pleasures. This paper adds to the literature and provides a comparison of values that would be beneficial to organizations and academic institutions in instilling values in their own setting
Unacylated ghrelin binds heparan-sulfate proteoglycans which modulate its function
Authors: Delhanty Patric J D , Huisman Martin , Prins Karina , Steenbergen Cobie , Mies Rosinda , Neggers Sebastian J C M M , van der Lely A J , Visser Jenny A
Published: December 2020

Acylated ghrelin (AG) is a gut-derived peptide with growth hormone secretagogue (GHS), orexigenic and other physiological activities mediated by GHS receptor-1a (GHSR). Ghrelin occurs in unacylated form (UAG) with activities opposing AG, although its mechanism of action is unknown. UAG does not antagonize AG at GHSR, and has biological effects on cells that lack this receptor. Because UAG binds to cells, it has been hypothesized that UAG acts via a cell-surface receptor, although this has not been confirmed. This study aimed to identify cell surface proteins to which UAG binds that could modulate or mediate its biological effects. The MCF7 cell-line was used as a model because UAG induces ERK signaling in these cells in the absence of GHSR. Using ligand–receptor capture and LC-MS/MS we identified specific heparan-sulfate proteoglycans (HSPGs) to which UAG interacts on cell surfaces. In line with this, UAG, as well as AG, bind with high affinity to heparin, and heparin and heparinase treatment suppress, whereas HSPG overexpression increases, UAG binding to MCF7 cell surfaces. Moreover, heparin suppresses the ERK response to UAG. However, conversion of the lysines in UAG to alanine, which prevents its binding to heparin and cell surface HSPGs, does not prevent its activation of ERK. Our data show that the interaction of UAG with HSPGs modulates its biological activity in cells. More broadly, the interaction of UAG and AG with HSPGs could be important for the specificity and potency of their biological action in vivo.
Modelación en problemas complejos y manejo de datos en Ingeniería Civil
Authors: Camilo Alejandro Corchuelo Rodriguez , Cristian Alexander Vega Mosquera , Luz Marina Paez
Published: December 2020

Este informe de entrega una consulta del estado de las patentes del tema “Modelación en problemas complejos y manejo de datos en Ingeniería Civil” de forma general. Se presenta la publicación y presentación por año, las palabras con mayor concurrencia, información de asignación por solicitantes y caracterización por industria y países. Este es un insumo para la comunidad académica USTA cuyo objetivo es potenciar la trasferencia de conocimiento y tecnología al sector productivo del país
Análisis de los resultados de los procesos de evaluación externa para acreditación de alta calidad de los programas de la Sede Principal Bogotá de la Universidad Santo Tomás
Authors: J Carrillo , J Marta , N Velásquez , E González
Published: December 2020

Los procesos de acreditación de alta calidad hacen parte del componente evaluativo del Sistema Interno de Aseguramiento de la Calidad de la Universidad Santo Tomás, como resultado del avance de los componentes de evaluación y autorregulación se evidencia la acreditación de 18 programas académicos de la Sede Principal Bogotá, de los cuales quince (15) son de pregrado y tres (3) de maestría. Para reconocer las buenas prácticas resultado de estos procesos y considerar las oportunidades de mejora, se realizó un análisis a la luz del modelo institucional de gestión universitaria para así detallar la convergencia de los resultados y tenerlos en cuenta para la toma de decisiones a nivel institucional, y el desarrollo de los nuevos procesos de acreditación de programas de pregrado y de posgrado y la renovación de la acreditación institucional.
Atributos de gobiernos corporativos universitarios y predicción de los niveles de divulgación de información: una aplicación de árboles de regresión
Authors: Claudio Mancilla , Juan Abello-Romero
Published: December 2020

En la temática de gobierno y gestión universitaria Abello (2018), Abello et al. (2018) y Abello et al. (2019) han demostrado que en promedio el nivel de divulgación de información de las universidades latinoamericanas es bajo y muy heterogéneo; también han demostrado que los atributos de los gobiernos corporativos universitarios o máximos cuerpos colegidos (MCC) son determinantes de la divulgación de información. Aunque los datos de más de doscientas universidades que fueron utilizados en estos trabajos representan ser un elevado número de observaciones, solo son una proporción de todas las universidades latinoamericanas; asimismo, el levantamiento de información para determinar los niveles de divulgación de información pudiera llegar a complejo, emerge la necesidad predecir y estimar cuál sería el nivel esperado de divulgación de otras universidades. En atención a lo anterior, el presente trabajo tiene por objetivo predecir los niveles de divulgación de información de universidades latinoamericanas considerando los atributos de sus gobiernos corporativos universitarios o máximos cuerpos colegiados (MCC). Para lograr el objetivo anterior, se introduce con una técnica utilizada en otras disciplinas y con otros propósitos denominada árboles de regresión. Si bien existen otras técnicas, como las regresiones lineales, los árboles de clasificación y regresión son parte de técnicas de machine learning para construir modelos de predicción de desde los datos disponibles (Loh 2011). Así, para el propósito de este trabajo, los árboles de regresión pueden ser una metodología apropiada para predecir los niveles de divulgación de información de universidades latinoamericanas. La técnica generará nodos o ramificaciones de acuerdo a los atributos de los MCC, lo que permitirá tipificar las universidades para posteriormente realizar una predicción del nivel de divulgación de información considerando dichos atributos. El nombre de la técnica deriva de la práctica habitual de describir el proceso de partición de os datos mediante un árbol de decisiones y una, entre otras, de las ventajas de los árboles de regresión es que son fáciles de entender e interpretar (Hernández 2020). Los resultados del presente trabajo indican que las universidades cuyos MCC son más diversos y más independientes son las tienen los mayores índices de divulgación de información, mientras que por el lado contrario, las universidades cuyos MCC son menos diversos, el número de miembros son de 49 o menos, y además son MCC menos independientes, son las instituciones que tienen los menos índices de divulgación de información.
Compositum mixtum of one-factor production function
Authors:   Institute of Industrial Economics of the NAS of Ukraine, Cherevatskyi Daniil
Published: November 2020

The paper is devoted to finding a convenient argument for the one-factor production function of a mine. For construction of one-factor production functions it is offered to use composite goods (compositum mixtum), the value of which corresponds to the amount of costs, incurred by an enterprise during a year-long period of time. Taking into account peculiarities of coal mines, the study verifies an expedience of converting the composite good to the coal equivalent (conventional fuel), consumed by an enterprise in a technological process, Big Mac burgers, and the stuff number. An attempt to use coal to build the production function of a mine as a composite good was not entirely successful. An experimental study of the dependence of coal production from actual costs of coal resources, carried out on a mathematical model of a mine, proved the inexpediency of such formalization, particularly due to the strong influence of non-mine (external) factors. Statistically significant, for example, were the efficiency of fuel use in power plants and the norm of coal for household needs. The relevance and popularity of the ‘sandwich index’ is due to the fact that McDonald's is in most countries, and Big Mac itself contains so many food ingredients (bread, cheese, meat and vegetables) that can act as a kind of mold of the national economy. But the conducted research demonstrated that such a way of expressing the composite good for Ukrainian mines is not rational due to macroeconomic interventions (permanent increase of the minimum wage) in the microeconomics of an enterprise. The most appropriate argument for the production function of the mine is the stuff number of an enterprise. The rationality of Big Mac as the basis of the production function is demonstrated in the construction of the production function of world export coal markets.
Automated Sanitization Device – Hand Sanitization, Thermal Screening and IoT-based Web-database
Authors: Samal Prathamesh , Roy Sutirtha , Chauhan Akash , Chauhan Vishu , Malhotra Vaibhav , Pundir Shivam , Singh Swatantra , Kanojia Jatin
Published: December 2020

In this time of great distress brought about by the COVID-19 pandemic, hand sanitization is of utmost priority to prevent the transmission of germs. We have come forth with an innovative “automated sanitization device” which makes the process of hand sanitization and temperature screening rapid, automatic and easier. The proposed automated sanitization device contributes significantly to prevent the spread of the virus and also raises awareness to increase hygiene at public places. The concept of embedded systems with various sensors attached to a PCB has been used in designing of the device. This paper addresses the methodological details of proposed automated sanitization device while focusing on its technical as well as financial expects. The proposed device is anticipated to be used at various public places like workplaces, residences, railway stations etc. working of this model, addressing both the technical as well as the financial aspect.
Considering existing classic and contemporary proposals for preventing online addiction problems: Some old recipes for new problems. •
Authors: Lopez-Fernandez Olatz
Published: November 2020

This commentary examines the proposed framework in relation to current policy options and preventive strategies and adds classical prevention and ecological models to tackle internet use-related addiction problems. Specifically, it highlights the preventive developments regarding contributions to promote the healthy use of technologies, and the need of designing and testing prevention strategies targeting the incidence, prevalence and severity of these problems at all population levels. In summary, to start preventing and minimising harms due to the problematic and addictive use of emerging technologies, we already have old models we can apply to these new problems to ensure secure behaviours through the technologies, and enhance users' wellness and quality of life.
PENGARUH PENAMBAHAN KARAGENAN EUCHEUMA COTTONII TERHADAP KARAKTERISTIK EKADO IKAN NILA
Authors: Sipahutar Yuliati Hotmauli , Rahman Muhamad , Panjaitan Tina FC
Published: November 2020

Penelitian ini bertujuan untuk mendapatkan pengaruh penambahan jumlah karagenan Eucheuma cottoni dalam pengolahan ekado ikan nila.. Penelitian ini dilakukan menggunakan metode rancangan acak lengkap dengan perlakuan 0%, 2,5%, 5%, 7,5%, 10%. Analisis data menggunakan Anova.  Kualitas ekado ditentukan berdasarkan hedonik dan kualitas kimianya. Hasil penelitian menunjukkan bahwa penambahan karagenan Eucheuma cottonii  berpengaruh signifikan  terhadap nilai hedonik dengan parameter kenampakan tekstur,  dan kualitas kimia dengan parameter kadar air, kadar abu, dan kadar protein, sedangkan dalam rasa, bau, penampilan dan kadar lemak tidak berpengaruh signifikan. Hasil terbaik untuk ekado dengan penambahan karagenan Eucheuma cottonii sebesar 5%, dengan nilai kenampakan 7,6, rasa 6,26, bau 6,95, tekstur 7,86, dan nilai kimia kadar air 66,98%, kadar abu 4,165% , kadar protein 15,2%, kadar lemak 2,05%. Penambahan karagenan Eucheuma cottoni sebagai bahan tambahan pangan pada ekado dapat meningkatkan tekstur ekado.
Penggunaan Mesin Induk Pada Alat Tangkap Purse Seine di KM. Surya Jaya
Authors: Ziliwu Boby Wisely , Musa Iskandar , Hutapea Roma Yuli F , Ziddin Hafiz
Published: November 2020

Mesin yang digunakan di kapal KM. Surya Jaya baik mesin induk maupun mesin penggerak motor adalah jenis mesin diesel. Mesin Diesel merupakan motor bakar dengan proses pembakaran yang terjadi didalam mesin itu sendri (Internal Combustion engine) dan pembakaran terjadi karena udara murni dimampatkan (dikompresi) dalam suatu ruang bakar (silinder) sehingga diperoleh udara bertekanan tinggi serta panas yang tinggi, bersamaan dengan itu disemprotkan / dikabutkan bahan bakar sehinga terjadiah pembakaran. Perbedaan antara mesin penggerak utama menggunakan jumllah silinder V-8 dan mesin penggerak generator menggunakan jumlah silinder 6. Dan antara mesin penggerak utama dan mesin penggerak generator memiliki sistem pendingin yang sama yaitu sistem pendingin terbuka, memiliki sistem bahan bakar yang sama dialiri dengan bahan bakar solar dari tangki yang sama dan penyaring minyak yang sama. Mesin induk dapat digunakan untuk menggerakan tenaga listrik untuk penerangan dalam aktifitas pengoperasian alat tangkap purse seine.
KAJIAN PENGENDALIAN MUTU PRODUK TUNA LOIN PRECOOKED FROZEN MENGGUNAKAN METODE SKALA LIKERT DI PERUSAHAAN PEMBEKUAN TUNA
Authors: Sumartini Sumartini , Harahap Kurnia Sada , Sthevany Sthevany
Published: November 2020

Industri pengolahan pangan dan hasil perikanan secara simultan meningkatkan concern di bidang keamanan pangan dan pengendalian mutu. Pengendalian mutu yang paling dasar adalah GMP (Good Manufacturing Practices) dan SSOP (Sanitation Standard Operating Procedure) sesuai dengan standar yang telah ditetapkan. Tujuan dari penelitian ini adalah untuk mengetahui dan mengkaji sistem pengendalian mutu pada proses pengolahan Tuna Loin Precooked Frozen sebagai dasar kunci pengambilan strategi dan kebijakan dalam penerapan pengendalian pangan dan hasil perikanan dalam skala eksport. Metode yang digunakan pada kajian pengendalian mutu ini menggunakan metode Skala Likert yang merupakan metode kuantitatif pengukuran pendapat seseorang menggunakan kuesioner untuk mengetahui skala sikap terhadap objek tertentu. Proses pengolahan Tuna Loin Precooked Frozen di Perusahaan Pembekuan Tuna X terdapat beberapa proses yaitu: Penerimaan bahan baku, Pelelehan, Penyiangan, Penyortiran, pemasakan, Pendinginan (spray I dan II), Pengkulitan, Pembersihan, Pengemasan (I), Pemvakuman, Pendeteksi Logam, Pembekuan, Pengemasan (II), Penyimpanan beku dan Pemuatan. Penilaian skala likert dari responden terhadap pengendalian mutu dengan hasil skor yang diperoleh dari kuesioner penerapan GMP (Good Manufacturing Practices) 92%, penerapan SSOP (Sanitation Standard Operating Procedure) 94,4% serta Pengendalian Mutu Terpadu 92%. Berdasarkan hasil tersebut maka Perusahaan Pembekuan Tuna X dapat menjadi alternatif industri pangan dan pengolahan hasil perikanan yang menerapkan dan melakukan pengendalian  manajemen mutu secara konsisten
KARAKTERISTIK MUTU TORTILA DENGAN PENAMBAHAN RUMPUT LAUT (Eucheuma Cottonii)
Authors: Panjaitan Pola Sabar , Panjaitan Tina FC , Siregar Arpan N , Sipahutar Yuliati Hotmauli
Published: November 2020

Penelitian ini bertujuan untuk mengetahui karakteristik mutu tortila dengan penambahan rumput laut  (Eucheuma Cottonii)..Penelitian dilakukan bulan Juni sampai bulan September 2019 di Workshop Pengolahan Poltek Karawang serta Laboratorium Kimia Sekolah Politeknik AUP  Jakarta. Penelitian dilakukan dengan eksperimen menggunakan  Rancangan Acak Lengkap (RAL) terdiri dari 1 perlakuan yaitu konsentrasi  rumput laut yang ditambahkan dengan 4 variabel yaitu konsentrasi A (0%), B (1%), C (1,5%) dan D(2%). dengan ulangan 3 kali. Analisis data dilakukan dengan Anova, apabila hasilnya berbeda nyata dilanjutkan dengan BNJ. Hasil Penelitian menujukkan : Tortilla A: kadar air 3,6%, kadar abu 2,95%, lemak 15,65%, protein 8,4%, dan kadar serat kasar 1,34%. Tortilla B: kadar air 4,4%, kadar abu 3,45%, lemak 19,4%, protein 8,55%, dan kadar serat kasar 1,49%. Tortilla C: kadar air 5,1%, kadar abu 4,15%, lemak 20,7%, protein 8,7%, % dan kadar serat kasar 1,63%. Tortilla D :  kadar air 5,6%, kadar abu 4,55%, lemak 23,15%, protein 9,05%, dan kadar serat kasar 1,75%. Perbedaan penambahan rumput laut berpengaruh nyata terhadap hasil uji kadar abu tortilla dan tidak berpengaruh nyata terhadap parameter lainnya
Determination of zinc compounds in yeast biomass
Authors: Thi Trang Nguyen , Thi Minh Khanh Nguyen , Duc Manh Le , Thoa Vu Kim , Dinh Binh Chu , Thi Lan Anh Pham
Published: November 2020

Zinc is an essential trace element for many physiological function in human and animal. When bound to organic substrate, zinc is more efficiently absorbed by organisms, has a high biological activity and a low toxicity. The ability of S. cerevisiae to accumulate zinc can be used for production of a zinc-rich ingredient for functional food products. However, only a few investigations on the form of Zn in S. cerevisiae have been reported. In this study, organic and inorganic compounds of zinc in yeast extract samples was separated on D101 macro-resin and quantified by inductively coupled plasma mass spectrometry (ICP-MS). Inorganic and organic compounds of zinc in yeast samples were extracted with photphate buffer by bead mills method and fractionated on the D101 macro-resin. All critical parameters of extraction conditions as well as separation conditions of zinc compounds on D101 macro-resin were investigated and optimized. In addition, speciation analysis of zinc compounds also was performed with online high-performance ion chromatography in combination with inductively coupled plasma mass spectrometry (HPIC-ICP-MS). Analyzed results indicated that the content of the organic state of Zn was more than that of the inorganic state. Organic zinc was the most abundance in yeast samples in the 51.56 – 88.17%. The highest organic zinc was found in S. cerevisiae A112 at 88.17%. In all of the samples, the organic zinc was found in the polysaccharide fraction was more than that of protein fraction. Our research results are significant for medical and food applications. Speciation analysis of trace element Zn is helpful to elucidate its pharmacological mechanism.