bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effects of In-person Counseling based on SDLMI on the Self-Determination Behaviors and Learned Helplessness of Adults with Intellectual Disabilities
Authors: Kim Gyeonghee , Han Sangmin , Han Songyi , Paik Eunhee
Published: June 2023

The purpose of this study was to examine the effects in-person counseling based on SDLMI on the self-determination behaviors and learned helplessness of adults with intellectual disabilities who were provided with in-person counseling for case management services in a social welfare center. The participants were two adults in their early twenties(one male, one female) and the effects of the SDLMI-based in-person counseling were measured using Self-determination Scale, Learned Helplessness Scale Scoring, and Goal Attainment Scale. Also, as a qualitative research method to describe perception changes of the participants, the Consensual Qualitative Research(CQR) was conducted for the conversation analysis. Results showed that both of the participants improved self-determination behaviors and showed positive changes in their learned helplessness. Also, the qualitative analysis based on the conversation between the counselor and the client showed that the participants’ perceptions associated with self-determination and learned helplessness had been changed in a more positive way. These results indicated that SDLMI could be an effective tool for adults with intellectual disabilities to be self-determined and that the model was evidenced to be effective when it was combined with in-person counseling services.
A Pilot Study for the Application of Gamification to Special Education: Focusing on a student at risk of brain injuries
Authors: Kim Byungkeon
Published: June 2023

As a pilot study for the application of gamification to special education, this study aimed to investigate the effects of applicability of a gamification-based augmented reality intervention for a student at risk of brain injuries. To this end, the Quiver developed based on gamification was used to verify the effects at baseline, intervention, and maintenance phases, and typological analysis was adopted to examine how gamification elements work on gamification has a significant effect on a student at risk of brain injuries. It was also confirmed that gamification elements work positively on the intervention. Based on the results of the study, the applicability of gamification on special education was discussed. Lastly, the limitations of this study were presented, based on which future studies were suggested.
The Effect of Function-Based Intervention Package on the Compliance of a Child with Brain Lesions
Authors: Kang Youngmo , Yang Moonbong
Published: June 2023

This study conducted a function-based intervention package to a child with brain lesions, and examined the changes and maintenance of compliance. The Differential Reinforcement of Incompatible of behavior (DRI) was applied, which has been proven to be effective in prior studies. The avoidance extinction were added to the noncompliance after considering the functions of behavior. Based on the Stimulus Preference Assessment (SPA) and Competing Stimulus Assessment (CSA) results, the individualized reinforcer were provided for compliance. In terms of variables, the function-based intervention package was set as independent variables and compliance with walking instructions as subordinate variables. The experimental control was demonstrated using the reversal design to the child with 1st-degree brain lesions currently attending special schools. As a result of the study deriving from visual analysis, the function-based intervention package increased the compliance of the child with brain lesions. It maintained the intervention effect even when no intervention was provided after the experiment ended. The study also showed the limitations in applying function-based intervention package to the child with brain lesions in special school and presented discussions on future studies.
The Effects of Individualized Positive Behavior Support on Temper Tantrum and Self-Injurious Behavior of a Child with Autism Spectrum Disorder
Authors: Lim Heejung , Lee Surnhee , Paik Eunhee
Published: June 2023

The purpose of this study was to investigate the effects of an individualized positive behavior support on temper tantrum and self-injurious behavior of a child with autism spectrum disorder(ASD). The study utilized multiple baseline design across setting: dinner time, discrete trial training and language rehabilitation. Individualized positive behavior support was conducted, including functional behavior assessment and behavior support plan which is background and setting event strategies, alternative behavior teaching strategies, and consequence strategies, in the dinner time, where temper tantrum and self-injurious behavior of a target child occur frequently, and in the discrete trial training and language rehabilitation of setting of the clinique. The results showed that individualized positive behavior support reduced the frequency of temper tantrum and self-injurious behavior of a child with ASD during both intervention and maintenance phase and generalized across the settings.
The Effects of Behavior Contract and Shadowing on Chinese Pronunciation and Speaking ability for Adult Chinese Beginners
Authors: Lin Meina , Lee Sung Bong
Published: June 2023

This study aims to exam the research questions of how behavioral contracts and shadowing affect the pronunciation and speaking of adult Chinese beginners. In this study, the researcher conducted interventions on three adults who did not have any experience in learning Chinese. To examine the research questions, the accuracy of Chinese pronunciation and speech of 3 participants were measured and analyzed through the evaluation sheet using the multiple-baseline design across participants, which consist of baseline, intervention, and maintenance 3 stages. To improve Chinese speaking ability, speaking instruction was conducted through behavioral contracts and shadowing, and it was evaluated using Chinese pronunciation and speaking evaluation papers. As a result of the study, the intervention method using the behavioral contract and shadowing improved Chinese pronunciation and speaking ability, and showed a high retention rate in the maintenance test. Even after the experiment, the study participants were using the learned words and phrases in an appropriate situation, and they expressed the expectation that it would be very helpful in studying Chinese in the future as they gained an overall understanding of Chinese. The results demonstrated that the behavior contract and shadowing method had a positive effect on pronunciation and speaking of the adult Chinese beginners.
The Effect of Behavioral Skills Training on the Accuracy of Discrete-Trial Teaching Implementation for Parents of Children with Developmental Disabilities
Authors: Shin Ju Won , Park Chan Woong , Lee Hyo Shin
Published: June 2023

The purpose of this study was to investigate the effect of a behavioral skills training involving written teaching, modeling, role-play, and feedback for performance accuracy and maintenance of discrete-trial teaching(DTT) procedures to three parents of children with developmental disabilities. Three parents of children with developmental disabilities were trained to implement discrete-trial teaching through behavioral skills training. A multiple baseline across participants design was used, consisting baseline, written instruction, modeling, role-play, feedback, and maintenance phases. The results demonstrated that behavioral skills training has improved the accuracy of DTT and maintained. Two participated parents reached mastery levels of correct implementation at the feedback phase. The results indicated that behavioral skills training could be an effective training method for parents of children with developmental disabilities.
Virtual Reality (VR) Serious Game Design Framework and Behaviorism Factors for Real Life Adaptation Skills Training for Children with Autism Spectrum Disorders(ASD)
Authors: Baek Jongnam
Published: June 2023

A serious game applying virtual reality (VR) is expected to be used as a tool for independent life training by inducing immersion and interest in children with Autism Spectrum Disorders(ASD). This study is to examine a framework for the development of a Virtual Reality-Serious Game(VR-SG) for training ASD children's real life adaptation skills through literature review, and to propose a behaviorist prototype for synchronizing VR-SG. The results of the study are as follows. First, the VR-SG framework approaches in three areas: pedagogy, learning content and game mechanism, and evaluation. Second, the behaviorist strategy for synchronizing VR-SG for real life adaptation skills training for students with ASD is to: (1) Clear application of reinforcement and punishment; (2) Induce continuity of participation in the game by applying the reinforcement plan; (3) diversification of behavioral chains for repetitive practice; (4) difficulty control using stimulation promotion; (5) diversification of reaction promotion according to personal preference. This study presented basic contents for use in the development of independent life training programs for children with ASD by studying the framework for developing functional virtual reality games for children with ASD.
Comparison of the medium cutoff dialyzer and postdilution hemodiafiltration on the removal of small and middle molecule uremic toxins
Authors: Kim Chang Seong , Joo Soo Yeon , Choi Hong Sang , Bae Eun Hui , Ma Seong Kwon , Kim Soo Wan
Published: June 2023

Background: The medium cutoff (MCO) dialyzer increases the removal of several middle molecules more effectively than high-flux hemodialysis (HD). However, comparative data addressing the efficacy and safety of MCO dialyzers vs. postdilution hemodiafiltration (HDF) in Korean patients are lacking. Methods: Nine patients with chronic HD were included in this pre-post study. Patients underwent HD with an MCO dialyzer for 4 weeks, followed by a 2-week washout period using a high-flux dialyzer to minimize carryover effects, and then turned over to postdilution HDF for 4 weeks. Reduction ratios and differences in the uremic toxins before and after dialysis were calculated from the MCO dialysis, postdilution HDF, and high-flux HD. In the in vitro study, EA.hy926 cells were incubated with dialyzed serum. Results: Compared to postdilution HDF, the MCO dialyzer achieved significantly higher reduction ratios for larger middle molecules (myoglobin, kappa free light chain [κFLC], and lambda FLC [λFLC]). Similarly, the differences in myoglobin, κFLC, and λFLC concentrations before and after the last dialysis session were significantly greater in MCO dialysis than in postdilution HDF. The expression of Bax and nuclear factor κB was decreased in the serum after dialysis with the MCO dialyzer than with HDF. Conclusion: Compared with high-volume postdilution HDF, MCO dialysis did not provide greater removal of molecules below 12,000 Da, whereas it was superior in the removal of larger uremic middle molecule toxins in patients with kidney failure. Moreover, these results may be expected to have an anti-apoptotic effect on the human endothelium.
The impact of hypoxia-inducible factors in the pathogenesis of kidney diseases: a link through cell metabolism
Authors: Foresto-Neto Orestes , da Silva Ana Ruth Paolinetti Alves , Cipelli Marcella , Santana-Novelli Fernanda Paula Roncon , Camara Niels Olsen Saraiva
Published: June 2023

Kidneys are sensitive to disturbances in oxygen homeostasis. Hypoxia and activation of the hypoxia-inducible factor (HIF) pathway alter the expression of genes involved in the metabolism of renal and immune cells, interfering with their functioning. Whether the transcriptional activity of HIF protects the kidneys or participates in the pathogenesis of renal diseases is unclear. Several studies have indicated that HIF signaling promotes fibrosis in experimental models of kidney disease. Other reports showed a protective effect of HIF activation on kidney inflammation and injury. In addition to the direct effect of HIF on the kidneys, experimental evidence indicates that HIF-mediated metabolic shift activates inflammatory cells, supporting the HIF cascade as a link between lung or gut damage and worsening of renal disease. Although hypoxia and HIF activation are present in several scenarios of renal diseases, further investigations are needed to clarify whether interfering with the HIF pathway is beneficial in different pathological contexts.
Marriage, Sexual Privacy, and Sodomy Statutes in the World: A Case Analysis
Authors: A Alim
Published: June 2023

According to the traditional Judeo-Christian moral and ethical standards, which conceive of sex in purely functional terms, i.e., for the purpose of procreation only. Now days the legislation criminalizing consensual oral and anal sex is outdated and has no place in modern society. By criminalizing private, consensual same-sex conduct, some countries in the world’s penal laws serves as the weapon for police abuse; detaining and questioning, extortion, harassment, forced sex, payment of hush money; and perpetuates negative and discriminatory beliefs towards same-sex relations and sexuality minorities. This sodomy laws thus creates a class of vulnerable people that is continually victimized and directly affected by the provision as well as sexuality minorities. The inalienable component of right to life, the pursuit of happiness encompassed within the concepts of privacy, human dignity, individual autonomy and the human need for an intimate personal sphere require that privacy dignity claim concerning private, consensual, sexual relations are also afforded protection within the ambit of the said fundamental right to life and liberty. There is almost unanimous medical and psychiatric opinion that homosexuality is not a disease or a disorder and is just another expression of human sexuality.
The Phenomenon of Suicide in the Elderly Subject
Authors: BS Yeladian
Published: June 2023

The article presents a theoretical framework on the Suicide Phenomenon in the Elderly Subject. Questions worthy of reflection will be addressed, such as the history of suicide through the ages to the present day, on the phenomenon of population growth which is signaled by the Brazilian Institute of Geography and Statistics (acronym in Portuguese IBGE), and the increase in the rate of suicides among the elderly in Brazil. This has drawn the attention of health authorities. According to the Ministry of Health, the suicide rate is 8.9 cases per 100 thousand inhabitants of individuals over 70 years old, between 2011 and 2016, the Brazilian average is 5.5 for each 100 thousand. This article aims to show some factors that lead the elderly subject to attempt against his own life, and how the Code of Ethics of the Psychology Professional can support in critical cases in which confidentiality must be broken, and in the psychologist's performance in the psychoanalytic view. of the management of elderly patients.
Antipsychotic-Like Activity of α-Asarone in Mice: A Preliminary Report
Authors: Pandy Vijayapandi
Published: June 2023

Alpha (α) - asarone is known to be one of the active compounds which have been discovered to be responsible for the therapeutic benefits of Acorus species. Previous studies have reported that Acorus calamus leaf extracts exerted the neuromodulatory effects on the nigrostriatal dopaminergic system. Therefore, the present study aimed to investigate the antipsychotic-like activity of α-asarone using a mouse model of apomorphine-induced stereotyped behaviour. Swiss albino male mice (bodyweight, 25-30g) were used for this study. In acute studies, α-asarone at different doses 1, 10, 30, 50, and 100 mg/kg bodyweight were administered orally one hour prior to apomorphine (5mg/kg, i.p.) injection respectively. Immediately after the injection of apomorphine, the mice were placed individually in cylindrical metal cages (18 cm in diameter and 19 cm in height) with the wall and floor consisting of vertical and horizontal metal bars and recorded for climbing time and climbing behaviour. The climbing behaviour was scored as 4 = four paws on the wall of the cage, 2 = two paws on the wall of the cage, 0 = four paws on the floor. The acute treatment of α-asarone (1-100 mg/kg, p.o.) exhibited an inverted bell-shaped dose-response in cage climbing behaviour. α-asarone at 30 and 50 mg/kg significantly decreased the apomorphine-induced cage climbing time and climbing behaviour in mice. These observed effects might be attributed due to the antidopaminergic property of α-asarone. Antagonism of dopamine D2 receptors is a common feature of the most clinically effective antipsychotic drugs, especially active against hallucinations and delusions. Overall, the present study uncovered the antidopaminergic effect of α-asarone; thereby α-asarone exhibited antipsychotic-like activity in mice. However, further neurochemical studies are warranted to explore the actual mechanism of action of α-asarone as a promising novel antipsychotic agent.
Development and Validation of Three Different UV Spectrophotometric Methods for Determination of New Antifungal Combination Used in Treatment of External Fungal Infections and Their Comparison Using ANOVA
Authors: Kansotia Ruchi
Published: June 2023

Luliconazole and Terbinafine hydrochloride combination is used for external fungal infections and is newly introduced in market. Hence it is necessary to develop a appropriate method of analysis for rapid and accurate determination of these drugs. Three simple, sensitive, accurate, precise and economical UV-spectrophotometric methods (A,B,C) have been developed for simultaneous estimation of Luliconazole and Terbinafine hydrochloride in their pharmaceutical dosage form and their comparison by ANOVA. Method (A) is well based on first order derivative spectrophotometric method, in which zero crossing points for Luliconazole is 249.50 nm and Terbinafine hydrochloride is 258.50 nm. Linearity was found in range of 3-18 µg/ ml for both the drugs using methanol as a common solvent. Method (B) is constructed on the principle of dual wavelength method using absorbance difference at 281 and 306 nm for Luliconazole & 262 and 296 nm for Terbinafine hydrochloride. Method (C) is based on norm of Q-absorbance ratio method where iso-absorptive point was obtained at 250 nm and the λ max selected was of Terbinafine hydrochloride 282 nm. The developed methods were validated as per ICH guideline. Accuracy and precision of methods were determined and validated. All the developed methods showed good reproducibility and recovery with % RSD <2. These three methods developed were compared using one way ANOVA and the fcal value was found to be less than ftab value indicating that there is no significant difference in the assay results of the three methods. All three methods were found to be rapid, specific, precise and accurate and found no interferences from the cream excipients so it can be used for routine investigation of both drugs in quality control laboratories.
Review Report on Natural Products as Anti-Fungal Agents
Authors: Gul Somia
Published: June 2023

Human fungal infections have been greatly increasing nowadays mainly, in patients of cancer, AIDS and those that are immunecompromised. Therefore, the usage of anti-fungal drugs has also been increased, resulting in resistance to the currently available drugs. The resistance to anti-fungal drugs has an inference to the health of the community. As the currently used anti-fungal drugs have limited effective activity, more drug-drug interactions, and toxicity issues, it seems essential to identify therapeutic options for fungal infections. Discovering new anti-fungal compounds from the natural products like plants could provide a significant source for new medicinal products. This review discusses the currently available natural products reported as antifungal agents, current status of those products, as well as, advancement and future perspective of natural products as anti-fungal agents.
Evaluation of In Vitro Antioxidant Activity of Stem Bark Extract of Lophira Lanceolata (Ochanaceae) Van Tiegh Ex Keay
Authors: Muhammad Amali Abubakar
Published: June 2023

Plants have been the mainstay of many traditional cultures for their low cost and wide accessibility for preventive and therapeutic uses. Lophira lanceolata van tiegh ex keay. is a plant belonging to the family Ochnaceae. It is a medicinal plant commonly used in west and central African regions. In Nigeria it is found in the North western region. This plant is well known and has been employed in the treatment of dermatosis, toothache, arthritis, headache, Cardiovascular diseases and many others. In this study, the in vitro antioxidant activity of the methanolic stem bark extract of L. Lanceolata methanolic leaf extract was investigated by determining the total phenolic content and DPPH radical scavenging activity using varied concentrations (31.25-500µg/ml) of the plant extract at absorbance of 515nm using ELISA plate reader. Ascorbic acid was used as the standard. From the results of the study, preliminary phytochemical screening indicated the presence of major Phyto-compounds like Flavonoids, alkaloids, steroids, terpenoids and saponins. The highest absorbance value that presents with the highest concentration revealed that the plant possesses radical scavenging activities. The present study indicates that, Lophira lanceolata has significant antioxidant activity and thus, support the claimed ethnomedical uses of the plant in the management of conditions associated with oxidative stress.
The Medical Qualities of the Elecampane, the Black Caraway and the Ivy According to Abū L-‘Alā’ Zuhr (D.1131)
Authors: Arvide Cambra Luisa Maria
Published: June 2023

Abū l- ‘Alā’ Zuhr (c.1060-1131), known among other names as Abuleli, is one of the most important physicians from AlAndalus who wrote on pharmacology and medicine. He also is the main author in Occident on popular scientific knowledge, as is Al-Majūsī (d.994) in Orient. Among his works, we find the treatise titled in Arabic Kitāb mujarrabāt al-khawāṣṣ (Book of the experience facts) that contains interesting descriptions on the healing attributes, the pharmacological properties and the medical characteristics of diverse plants and animals as well as other rare attributes included in the framework of folk medicine and the quackery, even magic and sorcery. This paper is an approach to this book and contains the English translation of Arabic text according to the manuscript no.520 of the Bodleian Library in Oxford relating to the elecampane (f.41vo-f.42ro), the black caraway (f.52vo-f.53ro) and the ivy (f.81vo.f.82ro).
Self-Assembling Property of Graphene Derivates Chemico-Physical and Toxicological Implication
Authors: Luisetto Mauro
Published: June 2023

This work start after seeing an recent open letter for transparency related production an quality control technique of mRNA vaccine first signed by Tarro G, Luisetto M and Monsellato ML and an editorial recognized by IMA Marijnskaya academy: Graphene and Derivate: Physio-Chemical and Toxicology properties in the mRNA Vaccine Manufacturing Strategy, needed specific proof of absence for the regulatory aspects (accepted for publication). Other relevant evidences related to this topic comes from the work of Giovannini, et al. related Dark field microscope assay of the blood of 1086 symptomatic subjects after vaccination with two types of m-RNA vaccine of great interest on this field also the work of P Campra and Young RO, Young Me Lee or Ki-Yeob J. Observing all this recent evidences the aim of this work is to investigate not only the graphene presence (or not) in vials of mRNA Vaccine but also the self-auto assembly properties of graphene and derivate. This is in order to find relationship in some biotechnological application like m-RNA Vaccine’s large scale production. After a review part an experimental hypothesis project will be submitted to the researcher to produce a global conclusion related the topic investigated. The recent evidences published induced the idea to more deeply study these properties for the clinicotoxicological aspects involved. The pro-coagulant properties of the coronavirus covid-19 Spike Protein are well knower by scientific literature as well as the toxicological profile of the graphene derivate. What can happen if this two substantive can act in patients with platelet disorder in the same time?
Convection-Enhanced Delivery of Alkaloid - Loaded Maghemite Nanoparticles against 9L - Gliomass Cell Line
Authors: Kumar Sahu Mahendra
Published: June 2023

Convection Enhanced Delivery (CED) is a novel approach to synthesize and facilitate targeted delivery of phytocontituents/ pharmaceuticals to the brain. The CED procedure involves a minimally invasive surgical exposure of the brain, followed by placement of small diameter catheters directly into the brain tumor. The study was designed to synthesize unique, sustained release, targeted delivery with no toxicity of piperidine alkaloids along with maghemite (γ-Fe2O3), poly-ethylene glycol and human serum albumin conjugation using 9L-gliomass cell line. Subsequently different nanoparticles (NPs) were prepared Naked NPs and HSA- or polyethylene glycol (PEG)-coated NPs with/without piperidine alkaloid were studied. In vitro results showed no toxicity and a similar cell-kill efficacy of the piperidine alkaloid-loaded particles via HSA coating to that of free piperidine alkaloid, while piperidine alkaloid-loaded particles via PEG coating showed low efficacy
Effect of Concurrent Administration of Herbs on the Pharmacokinetics of Drugs: A Review
Authors: Olugbenga Soyinka Julius
Published: June 2023

Herbal medicines are currently in high demand, and their popularity is steadily increasing as an alternative medicine. This is as a result of their perceived effectiveness, fewer side effects and relatively low cost. They are being used simultaneously with therapeutic drugs for the treatment and management of numerous medical conditions, but due to the complex mixture of bioactive constituents they are capable of affecting the pharmacokinetics and pharmacodynamics of conventional drugs when administered concurrently. Of serious concern is the concurrent consumption of herbal products and conventional drugs. Herb–drug inter-action (HDI) is the single most important clinical consequence of this practice. Using a structured assessment procedure, the evidence of HDI presents with varying degree of clinical significance. While the potential for HDI for a number of herbal products is inferred from non-human studies, certain HDIs are well established through human studies and documented case reports. This herb-drug interactions (HDIs) may lead to modifications in plasma drug levels resulting in therapeutic failure of the drug or, alternatively, it may cause drug-induced toxicity. The main routes proposed for HDIs include cytochrome P450 (CYP450)-mediated inhibition or induction and transport and flow proteins. In our review, some herbal medicines used for the treatment of various diseases were highlighted and case reports of their pharmacokinetics and pharmacodynamics herb-drug interactions were analyzed. Therefore, this review can be a quick reference tool for physicians, pharmacists and other healthcare professionals involved in therapy, and counseling towards appropriate use of drugs to maximize clinical outcomes.
Faropenem, a Stable and Orally Bioavailable β-Lactam, to Counteract Resistant Pathogens and Infectious Diseases
Authors: Bhalla Amit
Published: June 2023

Antimicrobial resistance is a huge challenge for the effective prevention and treatment of infectious diseases worldwide. Community-onset infections with extended-spectrum β-lactamases (ESBL) producing bacteria are a challenge. In various studies, ESBL-producing isolates were consistently susceptible only to carbapenems. When treatment with other antibiotics fails, carbapenems are used as the last-line antibiotics for treating severe and/or resistant bacterial infections. In this narrative review, we aim to present the pharmacology of Faropenem, which is an orally administered penem antibiotic with a broad-spectrum activity against many Gram-positive and Gram-negative aerobes, and anaerobes. Faropenem is effective in the treatment of uncomplicated cystitis and is a potential solution to combat the emergence of resistance among respiratory tract pathogens. It is an alternative to fluoroquinolones or macrolides/ketolides when there is a concern with resistant pathogens.
Ameliorative Potentials of Methanol and Ethyl Acetate Fractions of Peristophe Bicalyculata on Streptozotocine -Induced Diabetic Rats
Authors: Ofem E Eteng
Published: June 2023

Objective: The study investigated the ameliorative potentials of the ethyl acetate and methanol fractions of P. bicalyculata leaf extract on experimental rat models. Materials and Methods: A total of 35 albino Wistar rats were used for the study. They were randomly divided into 7 groups of 5 rats each. Group 1, the standard control, received 250mg/kg body weight (b.wt) of the anti-diabetic drug, Metformin, group 2 and 3 received 200 and 400mg/kg b.wt respectively of the methanol fraction of P. bicalyculata, (group 4 and 5 received 200 and 400mg/kg b.wt of the ethyl acetate fraction of P. bicalyculata respectively while groups6 and 7 were the diabetic control (DC) and normal control (NC) groups, respectively. Results: There was a significant decrease (p<0.05) in the serum levels of total cholesterol, TG, LDL, VLDL, and increased level of HDL cholesterol in streptozotocin (STZ) induced diabetic treated groups. The study also showed that there was a significant reduction in the fasting blood glucose (FBG) levels of the entire STZ induced diabetic rats treated with ethyl acetate and methanol extract of P. bicalyculata at 200mg/kg and 400mg/kg b.wt respectively. Also, the glycated haemoglobin and estimated average glucose concentrations showed a significant decrease (p<0.05) in the low and high doses of P. bicalyculata extract-treated groups compared to the DC. There was no significant (p>0.05) differences in the sex hormones (testosterone, luteinizing hormone and follicle stimulating hormone levels of rats in the treatment groups when compared to the NC group. Conclusion: The results obtained in the present study provide the scientific rationale for the use of P. bicalyculata as an antidiabetic agent in the management of diabetes.
Anthelmintic Resistance to Commonly Used Drugs in Naturally Infected Sheep in and Around Bekoji, Arsi Zone, Oromia, Ethiopia
Authors: Lemma Diriba
Published: June 2023

A study aimed at assessing parasites control practices in use and to determine existence of gastro intestinal nematodes resistance for Albendazole, Tetraclozash and Ivermectin, in naturally infected sheep under field conditions in and around Bekoji Town. Sheep of both sexes were randomly selected from small holder farmers from different peasant associations were used for this study. Before administering of the drugs, screening was done to identify infected sheep with gastro-intestinal nematodes and eggs per grams (EPG) greater than 200 were eligible for inclusion in the field experiment following guidelines by Coles and his colleagues (1). Accordingly a total of 48 animals grouped into four treatment groups’ of Albendazole, Tetraclozash, Ivermectin and Control (i.e. left untreated). Albendazole, Tetramisole and Ivermectin were found 90.53%, 98.1% and 96.59 % respectively. The percentage reduction of fecal egg counts (FECs) with 95% confidence intervals (CI), for Albendazole, Tetraclozash and Ivermectin were 95.83 %( 95.1 - 84.4CI), 98.1 % (99 - 90.99CI) and 96.59 % (97.01 - 91.3CI) respectively. Based on this findings Albendazole is resistant to the parasites in the area and it was concluded that development of anthelmintic resistance could be prevented by avoid frequent and unnecessary treatments of this anthelmintic, optioning instead for strategic deworming
Fungal Enzymatic Cocktails Benefits and Applications
Authors: Elkhateeb Wall A
Published: June 2023

The present review focused on production of enzyme cocktail (Cellulases, hemicellulases and pectinases) suitable for perfect biodiesel extraction process from different oil seeds especially Jatropha curcus L. by potent fungal producer utilizing some different abundant Egyptian lignocellulosic wastes. Enzyme cocktails is an eco-friendly process saving human from n-hexane toxicity and carcinogenicity. The enzymatic oil extraction instead of the organic solvent n- hexane is of great interest all over the world.
Bioactive Potential of Some Fascinating Edible Mushrooms Flammulina, Lyophyllum, Agaricus, Boletus, Letinula, Pleurotus as a Treasure of Multipurpose Therapeutic Natural Product
Authors: A Elkhateeb Wall
Published: June 2023

Since ancient times, several edible mushrooms have been reported as a nutritious food with valuable medicinal properties. The genera Flammulina; Lyophyllum; Agaricus; Boletus; Letinula and Pleurotus are a group of edible mushrooms that are distributed all over the world. The studies on different species of these edible mushrooms have revealed their nutritional medicinal potentials. This review aims to present the importance of the genera Flammulina; Agaricus; Boletus; Letinula; Pleurotus and Lyophyllum, as both food and medicine, and they offer new insights to researchers to develop new drugs and nutraceuticals.
Sharia Economic Dispute Resolution During Covid-19 Pandemic
Authors: Asriani Asriani , Surono Surono , Kumar Prodip
Published: June 2023

The process of resolving a case, especially concerning business disputes, generally runs slowly, drags on, and takes a long time, at least three months. This condition will, of course, burden the litigants, especially in cases where the value of the material claim is small. To overcome this problem, the Supreme Court issued PERMA No. 2 of 2015 in conjunction with PERMA Number. 4 of 2019 which regulates the Settlement of Simple Claims (Small Claim Court). What is meant by Simple Claim Settlement. is a procedure for examining a civil lawsuit with a material claim value of a maximum of 500 million rupiahs. With this regulation, it is hoped that the dispute resolution procedure can be simpler, faster, and less expensive. This study examines the court process for simple lawsuits related to Sharia business cases during the Covid-19 pandemic. The aim is to find out how the court process works and how effective the mechanism is in serving the interests of justice seekers. This research is a qualitative descriptive study using a juridical normative approach. The results showed that during the pandemic, the implementation of the small claim court was carried out using the e-court facility, and has proven to be effective and efficient in serving justice seekers.
Implementation of Sadd Dzari'ah in The Decision of Religious Courts Class I.B Blora Concerning Marriage Dispensation
Authors: Mutakin Ali , Yani Ahmad , Muslikaturohmah Siti
Published: June 2023

This research aims to analyze the judge's considerations in granting dispensation for child marriage in the Religious Courts Class I.B Blora (the case number 153/Pdt.P/2019/PA.Bla). This research is qualitative using a normative approach. Data were obtained through a review of several case examination documents, books, articles, journals, and regulations related to the research topic. According to the prevailing regulation, the age limit for marriage for both men and women is 19 years. If the man and woman have not reached the specified age, the family is allowed to apply for a marriage dispensation to the Court. This study found that the judge's considerations in deciding the case were based on the concept of sadd al-zari'ah (closing the path of evil). This is because in the case submitted there is two conflicting badness. First, the badness of early marriage relates to the health condition of the prospective bride and groom, which includes the health of reproductive organs, pregnancy, the expected child, and the possibility of a break in the household. Second, the bad impact that arises if the dispensation application was rejected, the two prospective brides continue to be involved in adultery. Of the two bad impacts, adultery is far worse. Based on the sadd al-dzarî'ah, the judge, therefore, granted the dispensation request.
Childfree: Between the Sacredness of Religion, Law and the Reality of Society
Authors: Nurjanah Siti , Nur Iffatin
Published: June 2023

One of the fundamental problems of a cultural shift in the contemporary era today is the existence of a phenomenon that is contrary to the norm. One of them is the childfree phenomenon with the main goal being the voluntary choice not to have children in a family. Seeing this phenomenon, it seems that it has brought about a shift that must be answered from the perspective of religion, Islamic law, and the reality of society. This is because so far the position of children in religion, law, and the reality of society is a group that must be protected. With the above problems, this study aimed to formulate an approach to the childfree phenomenon from the point of view of Islamic law, particularly the objectives of Islamic law (maqāshid sharī'ah) and the reality of society. Through literature review and literature study, this study finds that the main dimensions of the Islamic law approach model based on maqashid shari'ah and the reality of society are based on the benefit to be addressed and are in line and tandem with the reality of society. The phenomenon of being childfree is contrary to the mission and objectives of maqāshid sharī'ah and the reality of society. The conclusion of this study has strengthened the discourse of an Islamic Law study on the childfree phenomenon as one of the contemporary phenomena that should be responded to by using the perspective of benefits to people. Salah satu problem mendasar dari pergeseran budaya di era kontemporer saat ini adalah adanya fenomena yang berseberangan dengan kelaziman. Salah satunya adalah adanya fenomena childfree dengan tujuan utamanya adalah peniadaan anak dalam sebuah keluarga. Melihat fenomena tersebut, nampaknya membawa arus pergeseran yang harus dijawab oleh kaca mata agama, hukum Islam, dan realitas masyarakat. Hal ini dikarenakan selama ini posisi anak dalam agama, hukum, dan realitas masyarakat merupakan kelompok yang harus dilindungi. Dengan problem di atas, kajian ini bertujuan untuk merumuskan pendekatan terhadap fenomena childfree dengan kaca mata hukum Islam, terkhusus tujuan hukum Islam (maqashid syari’ah) dan realitas masyarakat. Melalui kajian pustaka dan studi literatur, kajian ini menemukan bahwa dimensi utama model pendekatan hukum Islam berbasis maqashid syari’ah dan realitas masyarakat didasarkan oleh kemaslahatan yang hendak dituju dan sejalan serta beriringan dengan realitas masyarakat. Terhadap fenomena childfree, childfree bertentangan dengan misi dan tujuan maqashid syari’ah dan realitas masyarakat. Kesimpulan dalam kajian ini telah menguatkan diskursus kajian hukum Islam bahwa fenomena childfree merupakan satu dari fenomena kontemporer yang harus direspon dengan kaca mata kemaslahatan dalam masyarakat.
Price Changes in A Limited Time in Home Shopping Program on RTV Television Media From The Perspective of Islamic Law
Authors: Arianti Farida , Yunarti Sri
Published: June 2023

This study aims to examine the views of Islamic law on price changes in a limited time in the Home shopping program on RTV television media and the implications for buying and selling activities in the program. This type of research is field research using a phenomenological approach. The data collection used observation techniques on RTV television social media and YouTube promo shows for home shopping products. The study results concluded that product sales in the home shopping program contain an element of uncertainty (gharar) by mixing prices over time; because the product is sold at a discount, that price is added to other goods at a specific price, which is an additional bonus. This activity causes the price to change from the price of the initially offered item and then added to the bonus item that must also be paid. This price is only valid for a short period, and then, after the promotion time is up, the price of the item being sold returns to the pre-discount price so that the selling price of the product offered is unclear (gharar) and contains an element of speculation which is not permitted in Islamic teachings.
Educational Media Introduction To Human Internal And External Organs For High School Students Based On Augmented Reality By Using The Assemblr Application
Authors: Murdhani I Dewa Ayu Sri , Oktavia Yunika Putri , Sholeh Muhammad
Published: June 2023

The development of information technology from year to year always experiences very rapid development, and one of the positive impacts of this development is the existence of innovation in the field of education. Education today already uses information technology, especially augmented reality (AR). The purpose of this study is to help high school students in getting to know human internal and external organs through 2D or 3D virtual objects projected against the real world. The features in the educational media for the introduction of human internal and external organs are learning materials, quizzes, and games to hone students' knowledge. The research method used is research and development (R&D). This research will produce AR applications that discuss human internal and external organs, in addition to the features that will be produced, namely learning materials, quizzes, and games. With these 3 features, it is hoped that high school students will understand the material about human internal and external organs. AR-based learning media is developed using the Assemblr application.
Escenas, cuerpos, archivos y persistencias: reflexiones en torno a las lecturas queer de Julián del Casal
Authors: Fernández Rocío
Published: June 2023

Hacia finales del siglo XX, siguiendo los pasos pioneros de Eve Kosofsky Sedgwick, tanto Oscar Montero con Erotismo y representación en Julián del Casal (1993) como Silvia Molloy con los ensayos que luego va a compilar en Poses de fin de siglo. Desbordes del género en la modernidad (2012) van a inaugurar nuevas formas de leer el modernismo latinoamericano. En este trabajo quisiera detenerme en las operaciones de lectura queer que surgen en torno a la figura de Julián del Casal a raíz del centenario de su muerte en 1993. En clave con las escenas que utiliza metodológicamente Molloy, tanto en los ´90 como en la primera década del 2000 surgen toda una serie de anécdotas e imágenes biográficas que van a dar a ver al cubano en su rareza y que propongo pensar a partir de un archivo visual que configura no solo una sensibilidad otra sino también formas de abrir la nación.
Development of an Introduction to Basic Mathematics Textbook Integrated with Islamic Values
Authors: Nursupiamin Nursupiamin , Badjeber Rafiq , Bagus Bagus
Published: June 2023

Abstract:Mathematics can be used as an approach to explaining several Islamic by interconnecting using conceptual and meta-mathematical foundations, thus producing integrated mathematics teaching materials. This study aims to describe the development of an integrated Introduction to Basic Mathematics textbook with Islamic values and then see student responses to the textbook. The type of research used is Research and Development (R&D) which refers to modified 4-D models. The instruments used are product validation sheets and response questionnaires. The data obtained were analyzed quantitatively and qualitatively. The results showed that the textbook Introduction to Basic Mathematics integrated with Islamic values was valid by the validators and very suitable for use by students with interesting categories. This finding can be the basis for the development of teaching materials by integrating Islamic values in Islamic universities.Abstrak:Matematika dapat digunakan sebagai pendekatan dalam menjelaskan beberapa ajaran Islam dengan cara interkoneksi menggunakan dasar konseptual maupun meta-matematis, sehingga menghasilkan bahan ajar matematika yang terintegrasi. Penelitian ini bertujuan mendeskripsikan pengembangan buku ajar Pengantar Dasar Matematika terintegrasi nilai keislaman kemudian melihat respon mahasiswa terhadap buku ajar tersebut. Jenis penelitian yang digunakan adalah Research and Development (R&D) yang mengacu pada model 4-D yang dimodifikasi. Instrumen yang digunakan adalah lembar validasi produk dan angket respon. Data yang diperoleh, dianalisis secara kuantitatif dan kualitatif. Hasil penelitian menunjukkan buku ajar Pengantar Dasar Matematika yang terintegrasi nilai-nilai keislaman dinyatakan valid oleh tim validator dan sangat layak digunakan oleh mahasiswa dengan kategori menarik. Temuan ini dapat menjadi dasar pengembangan bahan ajar dengan mengintegrasikan nilai-nilai keislaman di perguruan tinggi keislaman.
El amor, la bestia: alrededor de los seres imaginarios de Borges
Authors: López Aguilar Enrique
Published: June 2023

Se relata como surgieron, los trabajos de Borges, “Manual de zoología fantástica” y su secuela “Libro de los seres imaginarios”. Todo comenzó como empiezan y terminan muchas cosas: con un enamoramiento. Borges adoro a Margarita Guerrero así que, poseído por el enamoramiento, convenció a Margarita Guerrero para producir, conjuntamente, un Manual de zoología fantástica que recogería 82 ejemplares zooficticios. El Manual de zoología fantástica forma parte de las obras de difusión en las que Borges se propuso dar a conocer muestras breves de distintas épocas y tradiciones, bajo el precepto de que los textos elegidos fueran sugerentes, inquietantes y reveladores, En El libro de los seres imaginarios, el censo de los ejemplares se elevaría a 116, con la adición de seres no zoológicos como las hadas, el doble (el Doppelganger) y el Golem.
Bestias y bestiarios
Authors: Payró Rodrigo
Published: June 2023

Las colecciones de bestias o bestiarios en el sentido clásico, no son otra cosa que una clasificación, desde la razón (aquello que podemos soportar), del alter ego de las emociones, para entender a través del nombre y la descripción: darle sustancia, forma y cuerpo a lo desconocido, a lo terrible, a lo enteramente vivo; y así acotar, en lo posible, el origen de esa indescifrable emoción, que es una mezcla de miedo y repulsión ante nuestro propio deseo de sometimiento ante la belleza, que es lo que inspira la intención para el desarrollo de nuestras emociones. La descripción de las bestias es la descripción tanto de lo que somos, en silencio, como de lo que no podemos ser, por capacidad o represión (sea propia o ajena). Supernaturalia, en cambio, como bestiario, además de ser único en su tipo, junto con su complemento titulado simplemente Bestiario, describen un imaginario que nadie había catalogado antes.
War-Tested Resilience in Ukraine: Surviving Year One
Authors: Bojor Laviniu , Rațiu Aurelian , Tudorache Paul
Published: June 2023

The war in Ukraine, a NATO-Russian proxy war, continues to influence the global security architecture, but the immediate consequences are felt especially by those in the conflict area. The local population decided, through the actions carried out from the very first moment of the invasion, to oppose the Russian occupation and was categorized as an extension of the armed forces and a central pillar of the Ukrainian resistance. The paper analyzes the pressures to which the civilians in Ukraine were subjected during the first year of the conflict, such as: the bombing of residential areas, energy blackmail, torture, killings, rapes, robberies or the deportation of children from the occupied areas. After a year of war, the resilience of the population continues to fuel the morale of frontline troops, and a future peace agreement cannot be concluded without holding those guilty of war crimes or crimes against humanity accountable.