bluuebunny/crossref_metadata_2025 huggingface dataset:
Short-Term Betanin Intake Reduces Oxidative Stress in Wistar Rats
Authors: da Silva Davi Vieira Teixeira , Pereira Aline D’Avila , Boaventura Gilson Teles , Ribeiro Roberto Stefan de Almeida , Verícimo Maurício Afonso , Carvalho-Pinto Carla Eponina de , Baião Diego dos Santos , Del Aguila Eduardo Mere , Paschoalin Vania M. Flosi
Published: August 2019

Oxidative stress is a common condition described in risk factors for cardiovascular disease. Betanin, a bioactive pigment from red beetroot demonstrates anti-inflammatory and antioxidant properties. The main aim of this study was to evaluate the short-term intake of betanin against oxidative stress in a rodent model, a common condition described in several risk factors for cardiovascular disease. Oxidative stress was induced in Wistar rats by a hyperlipidemic diet for 60 days, followed by betanin administration (20 mg·kg−1) through oral gavage for 20 days. Plasma biochemical parameters and antioxidant enzyme activities were evaluated. Lipid peroxidation and histopathological changes were determined in the liver. The hyperlipidemic diet caused hyperglycemia, hyperinsulinemia, insulin resistance, and increases in alanine transaminase and aspartate transaminase levels. Oxidative stress status was confirmed by reduction of antioxidant enzyme activities, increased lipid peroxidation, and liver damage. Purified betanin regulated glucose levels, insulin, and insulin resistance. Hepatic damage was reversed as evidenced by the reduction in alanine transaminase and aspartate transaminase levels and confirmed by histological analyses. Betanin reduced hepatic malondialdehyde and increased superoxide dismutase, catalase, and glutathione peroxidase activities. Short-term betanin intake modulated biochemical parameters, reversed hepatic tissue damage, and attenuated oxidative stress in Wistar rats.
Role of Berry Bioactive Compounds on Lipids and Lipoproteins in Diabetes and Metabolic Syndrome
Authors: Basu Arpita
Published: August 2019

Blood lipids are an important biomarker of cardiovascular health and disease. Among the lipid biomarkers that have been widely used to monitor and predict cardiovascular diseases (CVD), elevated LDL and low HDL cholesterol (C), as well as elevated triglyceride-rich lipoproteins, deserve special attention in their predictive abilities, and thus have been the targets of several therapeutic and dietary approaches to improving lipid profiles. Among natural foods and nutraceuticals, dietary berries are a rich source of nutrients, fiber, and various types of phytochemicals. Berries as whole fruits, juices, and purified extracts have been shown to lower total and LDL-C, and increase HDL-C in clinical studies in participants with elevated blood lipids, type 2 diabetes or metabolic syndrome. This short review aimed to further discuss the mechanisms and magnitude of the lipid-lowering effects of dietary berries, with emphasis on reported clinical studies. Based on the emerging evidence, colorful berry fruits may thus be included in a healthy diet for the prevention and management of CVD.
Myocardial Dysfunction after Severe Food Restriction Is Linked to Changes in the Calcium-Handling Properties in Rats
Authors: Deus Adriana Fernandes de , Silva Vítor Loureiro da , de Souza Sérgio Luiz Borges , Mota Gustavo Augusto Ferreira , Sant’Ana Paula Grippa , Vileigas Danielle Fernandes , Lima-Leopoldo Ana Paula , Leopoldo André Soares , Campos Dijon Henrique Salomé de , de Tomasi Loreta Casquel , Padovani Carlos Roberto , Kolwicz Stephen C. , Cicogna Antonio Carlos
Published: August 2019

Severe food restriction (FR) impairs cardiac performance, although the causative mechanisms remain elusive. Since proteins associated with calcium handling may contribute to cardiac dysfunction, this study aimed to evaluate whether severe FR results in alterations in the expression and activity of Ca2+-handling proteins that contribute to impaired myocardial performance. Male 60-day-old Wistar–Kyoto rats were fed a control or restricted diet (50% reduction in the food consumed by the control group) for 90 days. Body weight, body fat pads, adiposity index, as well as the weights of the soleus muscle and lung, were obtained. Cardiac remodeling was assessed by morphological measures. The myocardial contractile performance was analyzed in isolated papillary muscles during the administration of extracellular Ca2+ and in the absence or presence of a sarcoplasmic reticulum Ca2+-ATPase (SERCA2a) specific blocker. The expression of Ca2+-handling regulatory proteins was analyzed via Western Blot. Severe FR resulted in a 50% decrease in body weight and adiposity measures. Cardiac morphometry was substantially altered, as heart weights were nearly twofold lower in FR rats. Papillary muscles isolated from FR hearts displayed mechanical dysfunction, including decreased developed tension and reduced contractility and relaxation. The administration of a SERCA2a blocker led to further decrements in contractile function in FR hearts, suggesting impaired SERCA2a activity. Moreover, the FR rats presented a lower expression of L-type Ca2+ channels. Therefore, myocardial dysfunction induced by severe food restriction is associated with changes in the calcium-handling properties in rats.
Bitter Orange (Citrus aurantium Linné) Improves Obesity by Regulating Adipogenesis and Thermogenesis through AMPK Activation
Authors: Park Jinbong , Kim Hye-Lin , Jung Yunu , Ahn Kwang Seok , Kwak Hyun Jeong , Um Jae-Young
Published: August 2019

Obesity is a global health threat. Herein, we evaluated the underlying mechanism of anti-obese features of bitter orange (Citrus aurantium Linné, CA). Eight-week-administration of CA in high fat diet-induced obese C57BL/6 mice resulted in a significant decrease of body weight, adipose tissue weight and serum cholesterol. In further in vitro studies, we observed decreased lipid droplets in CA-treated 3T3-L1 adipocytes. Suppressed peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT/enhancer binding protein alpha indicated CA-inhibited adipogenesis. Moreover, CA-treated primary cultured brown adipocytes displayed increased differentiation associated with elevation of thermogenic factors including uncoupling protein 1 and PPARγ coactivator 1 alpha as well. The effects of CA in both adipocytes were abolished in AMP-activated protein kinase alpha (AMPKα)-suppressed environments, suggesting the anti-adipogenic and pro-thermogenic actions of CA were dependent on AMPKα pathway. In conclusion, our results suggest CA as a potential anti-obese agent which regulates adipogenesis and thermogenesis via AMPKα.
Investigation of Power Transmission of a Helium Plasma Jet to Different Dielectric Targets Considering Operating Modes
Authors: Teschner Tilman , Bansemer Robert , Weltmann Klaus-Dieter , Gerling Torsten
Published: August 2019

The interaction of an atmospheric pressure plasma jet with different dielectric surfaces is investigated using a setup of two ring electrodes around a ceramic capillary. In this study, in addition to electrical measurement methods such as the determination of voltage and current, special emphasis was placed on the power measurements at the electrodes and the effluent. The power dissipation is correlated with Fourier-transform infrared (FTIR) absorption spectroscopy measurements of O3 and NO2 densities. The results show the correlation between the dielectric constant and the dissipated power at the target. The ratio between power dissipation at the grounded ring electrode and the grounded surface shows an increase with increasing dielectric constant of the target. A correlation of the results with bacteria, tissue and water as envisaged dielectric targets shows four times the power dissipation at the treatment spot between bacteria and tissue.
An E-Nose for the Monitoring of Severe Liver Impairment: A Preliminary Study
Authors: Germanese Danila , Colantonio Sara , D’Acunto Mario , Romagnoli Veronica , Salvati Antonio , Brunetto Maurizia
Published: August 2019

Biologically inspired to mammalian olfactory system, electronic noses became popular during the last three decades. In literature, as well as in daily practice, a wide range of applications are reported. Nevertheless, the most pioneering one has been (and still is) the assessment of the human breath composition. In this study, we used a prototype of electronic nose, called Wize Sniffer (WS) and based it on an array of semiconductor gas sensor, to detect ammonia in the breath of patients suffering from severe liver impairment. In the setting of severely impaired liver, toxic substances, such as ammonia, accumulate in the systemic circulation and in the brain. This may result in Hepatic Encephalopathy (HE), a spectrum of neuro–psychiatric abnormalities which include changes in cognitive functions, consciousness, and behaviour. HE can be detected only by specific but time-consuming and burdensome examinations, such as blood ammonia levels assessment and neuro-psychological tests. In the presented proof-of-concept study, we aimed at investigating the possibility of discriminating the severity degree of liver impairment on the basis of the detected breath ammonia, in view of the detection of HE at its early stage.
Leveraging Visual Place Recognition to Improve Indoor Positioning with Limited Availability of WiFi Scans
Authors: Nowicki Michał R. , Skrzypczyński Piotr
Published: August 2019

WiFi-based fingerprinting is promising for practical indoor localization with smartphones because this technique provides absolute estimates of the current position, while the WiFi infrastructure is ubiquitous in the majority of indoor environments. However, the application of WiFi fingerprinting for positioning requires pre-surveyed signal maps and is getting more restricted in the recent generation of smartphones due to changes in security policies. Therefore, we sought new sources of information that can be fused into the existing indoor positioning framework, helping users to pinpoint their position, even with a relatively low-quality, sparse WiFi signal map. In this paper, we demonstrate that such information can be derived from the recognition of camera images. We present a way of transforming qualitative information of image similarity into quantitative constraints that are then fused into the graph-based optimization framework for positioning together with typical pedestrian dead reckoning (PDR) and WiFi fingerprinting constraints. Performance of the improved indoor positioning system is evaluated on different user trajectories logged inside an office building at our University campus. The results demonstrate that introducing additional sensing modality into the positioning system makes it possible to increase accuracy and simultaneously reduce the dependence on the quality of the pre-surveyed WiFi map and the WiFi measurements at run-time.
Wellness Assessment of Alzheimer’s Patients in an Instrumented Health-Care Facility
Authors: Masciadri Andrea , Comai Sara , Salice Fabio
Published: August 2019

Wellness assessment refers to the evaluation of physical, mental, and social well-being. This work explores the possibility of applying technological tools to assist clinicians and professionals to improve the quality of life of people through continuous monitoring of their wellness. The contribution of this paper is manifold: a coarse-grained localization system is responsible for monitoring and collecting data related to patients, while a novel wellness assessment methodology is proposed to extract quantitative indicators related to the well-being of patients from the collected data. The proposed system has been installed at “Il Paese Ritrovato", an innovative health-care facility for Alzheimer’s in Monza, Italy; first satisfactory results have been obtained, and the dataset shows great potential for several applications.
Nonlinearity Correction in OFDR System Using a Zero-Crossing Detection-Based Clock and Self-Reference
Authors: Zhao Shiyuan , Cui Jiwen , Tan Jiubin
Published: August 2019

Tuning nonlinearity of the laser is the main source of deterioration of the spatial resolution in optical frequency-domain reflectometry (OFDR) system. In this paper, we develop methods for tuning nonlinearity correction in an OFDR system from the aspect of data acquisition and post-processing. An external clock based on a zero-crossing detection is researched and implemented using a customized circuit. Equal-spacing frequency sampling is, therefore, achieved in real-time. The zero-crossing detection for the beating frequency of 20 MHz is achieved. The maximum sensing distance can reach the same length of the auxiliary interferometer. Moreover, a nonlinearity correction method based on the self-reference method is proposed. The auxiliary interferometer is no longer necessary in this scheme. The tuning information of the laser is extracted by a strong reflectivity point at the end of the measured fiber. The tuning information is then used to resample the raw signal, and the nonlinearity correction can be achieved. The spatial resolution test and the distributed strain measurement test were both performed based on this nonlinearity correction method. The results validated the feasibility of the proposed method. This method reduces the hardware and data burden for the system and has potential value for system integration and miniaturization.
Evaluation of Water Use Efficiency of 31 Provinces and Municipalities in China Using Multi-Level Entropy Weight Method Synthesized Indexes and Data Envelopment Analysis
Authors: Sun Boyang , Yang Xiaohua , Zhang Yipeng , Chen Xiaojuan
Published: August 2019

China’s water shortage problem is becoming increasingly severe. Improving water use efficiency is crucial to alleviating China’s water crisis. This paper evaluates the water use efficiency of 31 provinces and municipalities in China by using the data envelopment analysis (DEA) method. When the usual DEA model has too many indexes selected, it will cause the majority of the decision making units (DMUs) efficiency values be one, which leads to invalid evaluation results. Therefore, by using the entropy weight method, a new synthetic set of indexes is constructed based on the original indexes. The new synthetic set of indexes retains the full information of the original indexes, and the goal of simplifying the number of indexes is achieved. Simultaneously, by empowering the original indexes, the evaluation using synthetic indexes can also avoid the impact of industrial structure and labor division on water use efficiency. The results show that in China’s northeastern grain producing areas, water use efficiency is higher due to the high level of agricultural modernization. The provinces in the middle reaches of the Yangtze River have the lowest water use efficiency due to water pollution and water waste. In general, China’s overall water use efficiency is low, and there is still much room for improvement.
Industrial Big Data and Computational Sustainability: Multi-Method Comparison Driven by High-Dimensional Data for Improving Reliability and Sustainability of Complex Systems
Authors: Liu Chunting , Jia Guozhu
Published: August 2019

Sustainable development is of great significance. The emerging research on data-driven computational sustainability has become an effective way to solve this problem. This paper presents a fault diagnosis and prediction framework for complex systems based on multi-dimensional data and multi-method comparison, aimed at improving the reliability and sustainability of the system by selecting methods with relatively superior performance. This study took the avionics system in the industrial field as an example. Based on the literature research on typical fault modes and fault diagnosis requirements of avionics systems, three popular high-dimensional data-driven fault diagnosis methods—support vector machine, convolutional neural network, and long- and short-term memory neural network—were comprehensively analyzed and compared. Finally, the actual bearing failure data were used for programming in order to verify and compare various methods and the process of selecting the superior method driven by high-dimensional data was fully demonstrated. We attempt to provide a sustainable development idea that continuously explores multi-method integration and comparison, aimed at improving the calculation efficiency and accuracy of reliability assessments, optimizing system performance, and ultimately achieving the goal of long-term improvement of system reliability and sustainability.
Rights–Values–Interests: The Conflict between World Cultural Heritage and Community: A Case Study of the West Lake Cultural Landscape Heritage in China
Authors: Lu Jiancheng , Luo Xiaolong , Zhang Peigang
Published: August 2019

The conflict between world cultural heritage and local communities is investigated by using the cultural landscape heritage of West Lake in China as a case study, and establishing an analytical framework of “Rights–Values–Interests” based on the property rights theory of the new institutional economics and the value and interest structure characteristics of cultural heritage. The conflict problem in the market environment is analyzed based on a theoretical explanation. An in-depth discussion of the framework and improvement of China’s protection institution is provided. We outline the following key points: First, the Chinese government “plundered” certain behavior rights and legitimate interests of community residents through the enactment of protection laws, leading to a conflict between the protection and community. Second, China’s laws lack a clear definition of the power and responsibility of the central and local governments with regard to protection actions, leading to vague positions of the government and exacerbating conflicts. Third, China’s protection laws are out of touch with the laws of private property rights. The root cause of the conflict is that the protection action only considers the protection law as the core but neglects the residents’ legal behavior rights. Finally, from the perspective of considering the residents’ legitimate interest demands, defining behavior rights boundaries, and strengthening administrative management, we propose to improve the protection institution in order to achieve the harmonious integration of heritage protection and local communities, and we call for a greater focus on the legitimate interests or survival rights of ordinary Chinese community residents.
Debunking the Myth of Foreign Direct Investment toward Long-Term Sustainability of a Developing Country: A Transaction Cost Analysis Approach
Authors: Nguyen Hoang Viet , Phan Thanh Tu , Lobo Antonio
Published: August 2019

This study focuses on the relationship between foreign direct investment (FDI) and sustainability in a developing host country, i.e., Vietnam, using the transaction cost approach. Secondary panel data were obtained from 62 provinces in Vietnam for the period between the years of 2010 and 2016. The analysis of the data was performed using the fixed effects regression model, which yielded interesting and controversial findings. Essentially, it was demonstrated that the FDI made by enterprises and the subsequent employment that it generated had several positive and significant influences on the long-term sustainability of provinces in Vietnam. However, the downside was that the value of fixed assets and long-term investment of FDI projects in conjunction with the size of the provinces negatively influenced their long-term sustainability. The findings of this study have important academic and practical implications. We propose some policy changes that would considerably improve the efficacy and effectiveness of FDI. This, in turn, will certainly enhance the long-term sustainability of host countries, especially developing ones.
Towards Sustainable Agriculture—Agronomic and Economic Effects of Biostimulant Use in Common Bean Cultivation
Authors: Szparaga Agnieszka , Kuboń Maciej , Kocira Sławomir , Czerwińska Ewa , Pawłowska Anna , Hara Patryk , Kobus Zbigniew , Kwaśniewski Dariusz
Published: August 2019

Today, one of the greatest challenges faced by the agriculture industry is the development of sustainable and environmentally-friendly systems to meet nutritional demands of the continuously growing global population. A number of research studies have recently been undertaken with the aim to indicate types of parameters used in plant production that would be able to improve plant growth as well as the effectiveness and quality of yield, and to help plants cope with environmental stress. The aim of this study was to verify a hypothesis that the implementation of a sustainable agricultural technology, based on the use of synthetic biostimulants, will allow not only increasing crop yield and quality but also improving the cost-effectiveness of common bean cultivation. The field experiment was conducted in three growing seasons (2016–2018). In the growing season, the plants were treated with Atonik and Tytanit biostimulants in the form of single or double spraying. We determinated biometric traits, seed yield, seed number, and 1000-seed weight. Further analyses included contents of nutraceutical potential. The economic effect of using biostimulants was also calculated. The results of our experiment allowed verifying a hypothesis that the implementation of a sustainable agricultural technology based on the use of synthetic preparations was an effective method to increase plant productivity and, consequently, economic profits to farmers.
Reduced Renal Colonization and Enhanced Protection by Leptospiral Factor H Binding Proteins as a Multisubunit Vaccine against Leptospirosis in Hamsters
Authors: Techawiwattanaboon Teerasit , Barnier-Quer Christophe , Palaga Tanapat , Jacquet Alain , Collin Nicolas , Sangjun Noppadon , Komanee Pat , Piboonpocanun Surapon , Patarakul Kanitha
Published: August 2019

Subunit vaccines conferring complete protection against leptospirosis are not currently available. The interactions of factor H binding proteins (FHBPs) on pathogenic leptospires and host factor H are crucial for immune evasion by inhibition of complement-mediated killing. The inhibition of these interactions may be a potential strategy to clear leptospires in the host. This study aimed to evaluate a multisubunit vaccine composed of four known leptospiral FHBPs: LigA domain 7–13 (LigAc), LenA, LcpA, and Lsa23, for its protective efficacy in hamsters. The mono and multisubunit vaccines formulated with LMQ adjuvant, a combination of neutral liposome, monophosphoryl lipid A, and Quillaja saponaria fraction 21, induced high and comparable specific antibody (IgG) production against individual antigens. Hamsters immunized with the multisubunit vaccine showed 60% survival following the challenge by 20× LD50 of Leptospira interrogans serovar Pomona. No significant difference in survival rate and pathological findings of target organs was observed after vaccinations with multisubunit or mono-LigAc vaccines. However, the multisubunit vaccine significantly reduced leptospiral burden in surviving hamsters in comparison with the monosubunit vaccines. Therefore, the multisubunit vaccine conferred partial protection and reduced renal colonization against virulence Leptospira infection in hamsters. Our multisubunit formulation could represent a promising vaccine against leptospirosis.
Making Sense of “Day Zero”: Slow Catastrophes, Anthropocene Futures, and the Story of Cape Town’s Water Crisis
Authors: Shepherd Nick
Published: August 2019

What form do the current and future catastrophes of the Anthropocene take? Adapting a concept from Rod Nixon, this communication makes a case for the notion of slow catastrophes, whose unfolding in space and time is uneven and entangled. Taking the events of Cape Town’s Day Zero drought as a case study, this paper examines the politics and poetics of water in the Anthropocene, and the implications of Anthropogenic climate change for urban life. It argues that rather than being understood as an inert resource, fresh drinking water is a complex object constructed at the intersection between natural systems, cultural imaginaries, and social, political and economic interests. The extraordinary events of Day Zero raised the specter of Mad Max-style water wars. They also led to the development of new forms of solidarity, with water acting as a social leveler. The paper argues that the events in Cape Town open a window onto the future, to the extent that it describes something about what happens when the added stresses of climate change are mapped onto already-contested social and political situations.
Transient Flow and Transport Modelling of an Historical CHC Source in North-West Milano
Authors: Colombo Loris , Alberti Luca , Mazzon Pietro , Formentin Giovanni
Published: August 2019

Legislative Decree 152/2006 requires Public Authorities to identify the subjects who are responsible for soil and groundwater contamination. In highly urbanized areas with a long industrial history and an elevated number of potential contaminant sources, as in N-W Milano Functional Urban Area (FUA), their identification can be difficult. Since the groundwater flow has showed consistent changes in the last 30 years as in Milan, the problem became even more complicate. The Public Authorities put in charge by the law, i.e., Regione Lombardia and Città Metropolitana Milanese, need new methodologies to assist them in finding the source locations and implementing remediation actions. The aim of this study is, coupling unsteady flow with fate and transport model of Chlorinated Hydrocarbons, to reconstruct the potential impact of a former chemical plant on public wells in the N-W area of Milano. The proposed methodology consists in (a) reconstruction of the piezometric trend over time (1980–2018) by means of a transient flow model (MODFLOW2005 + Parameter Estimation - PEST) and (b) simulation of transport as a function of the flow variations in time. The obtained results were compared with the previous ones obtained with a quasi-steady model (no changes in time-dependent parameters). Finally, a predictive scenario was performed to assess the potential evolution of tetrachloroethylene (PCE) in groundwater; on this frame, strategies to monitor and remediate the contamination were proposed.
Theology, Metaphysics, and Science: Twenty-First Century Hermeneutical Allies, Strangers, or Enemies?
Authors: Antoci Peter M.
Published: August 2019

This article answers the question of whether the study of theology and metaphysics can be classified currently, or ever qualify in the future, as a scientific endeavor. Rather than choose a particular theology or metaphysics as the subject of inquiry, this essay argues that it is not only necessary to recognize the role of hermeneutics within different fields of study, but that it is also necessary to begin a human hermeneutic with human experience. Changes in our global context, whether social, economic, political, or environmental, are important drivers of hermeneutical evolution. We should expect no less change in the areas of theology, metaphysics, and science. The question of truth, whether subjective or objective, is a hermeneutical one.
Türkiye ‘de Bitkisel Tıbbi Ürünler (Türkiye’de Bitkisel Ürünlerin Standardizasyonu, Üretimi Ve Tağşiş)
Authors: DİŞLİ Meryem , YEŞİLADA Erdem
Published: August 2019

Fitoterapinin dünyadaki tarihsel gelişimi birçok çalışmada defalarca vurgulanmıştır. Ülkemizde ise getat mevzuatıyla beraber popülaritesi artan bir bilim dalı haline gelmiştir. Fitoterapi eğitimleri yıllardır Eczacılık Fakültelerinde Farmakognozi Anabilim dalı adı altında verilmekteydi. T.C Sağlık Bakanlığı’nın 2014 Geleneksel ve Tamamlayıcı Tıp (GETAT) mevzuatıyla beraber, yetki verilen üniversitelerce eğitimler yaygınlaştırılmış, eğitim alan hekim ve eczacı sayısı hızla artmıştır. Sonuçta hedef insan sağlığı ve tedavi olunca, fitoterapinin de gelişigüzel uygulanması düşünülemeyeceğinden, kanıta dayalı fitoterapi konusu gündeme gelmiştir ki; bunu da doğru endikasyonda, uygun dozda istenen maximum etki ve her uygulamada aynı etki şeklinde açıklamak doğru olacaktır. Bu noktada kullanılacak bitkisel ürünlerde kalite ve standardizasyonun önemi iyice belirginleşmektedir. Bu nedenle bu çalışmada bitkinin yetiştirilme sürecinden, drog ve ilaç haline gelinceye ve de artık uygulama ve tedavi boyutunda olması gereken kalite ve standardizasyon konusuna vurgu yapılması amaçlanmıştır.
Apiterapiye Genel Bakış
Authors: ATAYOĞLU Ali Timuçin
Published: August 2019

Apiterapi,
Geleneksel ve Tamamlayıcı Tıp Uygulamaları Yönetmeliği’nde; arı ve arı
ürünlerinin koruyucu ve bazı hastalıkların tedavisinde destek olarak
kullanılması şeklinde tanımlanmıştır. Başlıca arı ürünleri bal, balmumu, arı
poleni, propolis, arı sütü, arı zehri ve bunların türevleridir. Bu ürünler
üzerine pekçok araştırma “sağlığı koruma” potansiyelini desteklemektedir.
Apiterapide kullanılan ürünlerin standardizasyonu konusundaki eksiklikler apiterapiyle
ilgili klinik çalışmaların  yapılabilmesini zorlaştıran temel
etkenlerdendir. Beklenilen olumlu etki için kullanılan ürünün kaliteli olması
şarttır. İlgili yönetmelik, ürünlerde kimyasal analizlerin yapılmış olması ve
belli kurallara uygunluk şartı getirmiştir.
Klinik Mikrobiyoloji Laboratuvarlarında Yapay Zekanın Temel İşleyiş Modelleri
Authors: ŞAHİN Ahmet Rıza , ATEŞ Selma , GÜNAY Mücahid
Published: August 2019

Yapay
zekanın tıp alanındaki ana ilgi alanı, teşhis ve tedavi önerileri sunabilecek
yöntemler geliştirmek gibi görünse de hekim ve hemşire klinik karar destek sistemleri, eczane karar destek
sistemleri, hasta bakımı, klinik veri havuzu oluşturulması, birimler ve
kurumlar arası veri paylaşımı, depolama, yorumlayabilmeye sürecine katkı ile
beraber olarak iş zekası ve makine öğrenmesi gibi sayısız alanı kapsar. Tıbbi laboratuvarlar
otomasyon, uzman sistemler ve yapay zekaya doğru güçlü bir yönelimle karşı karşıya
olmanın yanısıra uzman sistemlere yönelik artan bir ihtiyaç yaşamaktadır. Klinik
mikrobiyoloji laboratuvarları antimikrobiyal dirence karşı mücadelede yer
alabilecek veri zincirlerinin tespitinde merkezi bir unsurdur. Yapay zekanın klinik mikrobiyoloji laboratuvar kullanımına entegrasyonun
amaçları arasında bireysel epidemiyolojik sürveyans, araştırma uygulamalarına
ayrıntılı destek sağlamanın yanı sıra bireysel hasta bakım kalitesini artırmak
yer alır. Çalışmamızda klinik mikrobiyoloji ve antibiyotik
direncinin işlenmesi konusunda farklı
yapay zeka çalışma prensip ve yöntemleri gözden geçirilerek, bu yöntemleri
irdeleyen önemli klinik çalışmalar incelenmiştir.
Metode Penilaian Kondisi Jembatan Beton Prategang
Authors: Hasanudin Hasanudin
Published: August 2019

Abstract— Bridges as one of the infrastructure that plays a role in supporting ground transportation, during it service will experience a decrease in conditions caused by the influence of traffic loads, weather effects, environmental influences or other influences. To eliminate the interference required maintenance. A building maintenance including a bridge is preceded by a condition checking activity, and subsequent assessment of conditions. During this examination and assessment of the condition of the bridge refers to the method of inspection and assessment of the conditions set in Bridge Management System (BMS) 1993. There are still weaknesses in the assessment of conditions with Bina Marga BMS caused by the absence of methods of assessing the condition of prestressed concrete bridges. This research is a development of BMS condition assessment, to be used as an assessment of prestressed concrete bridge condition. The object of this research is focused on prestressed precast concrete bridge, namely Kiaracondong Bridge (Bandung) and Cimindi bridge (Cimahi) West Java. The method of assessing the condition undertaken is the examination of damage to the bridge components (physical indicator) through visual inspection, not equipped with destructive and non destructive testing (advanced stage of inspection). Assessment of the conditions developed is the assessment of conditions on the security aspects of the structure and aspects of traffic convenience, where the structure security aspect is the multiplication of the condition of the main part of the building over the bridge. After doing research it can be seen that Cimindi bridge condition value is 3,5-4,25 (need monitoring) and Kiaracondong bridge (very good). The deficiency in the method of assessing the condition in this study is that the assessment of the condition of the bridge is done visually only, so it can not predict the damage to the prestressed concrete components inside. Further examination is required after examination and assessment of this condition is done especially when it is found suspicious things.Keywords: Bridge Management System; Assessment of bridge condition; Prestressed Concrete
Perencanaan Distribusi Gas LPG 3 kg Menggunakan Metoda Distribution Requirement Planning (DRP) di PT Anugrah Ditamas Lestari
Authors: Suryana Hendy , Faruk Umar
Published: August 2019

Gas is a contributing factor in various industrial and household activities. PT Anugrah Ditamas Lestari is one of the 3kg lpg gas agent that was established since 2008. The problem that happened in PT Anugrah Ditamas Lestari is that lpg gas sales will be hampered and can not be done in a timely manner will eventually cause loss. Forecasting Linear Regression starts from January 2015 to December 2016, while the DRP (distribution requirement planning) applied in research in gas agents is to know the needs for each base it can be known from the value of gross requirement. the need for a hilman base in 2016 is 63728 tubes / year, Asep.R 58898 tubes / year, Dedin 59961 tubes / year, Didin 58524 tubes / year, muhyidin 8771 tubes / year, suherman 77919 tubes / year, Haris 60108 tubes / year , Ujang 62964 tube / year, Irfan 54095 tube / year while for the maman base of 56826 tubes / year. As for knowing the needs and determining the delivery of lpg gas to each base can be seen from the calculation of pland order release, for the Hilman base it needs a gas supply of 63700 tubes / year, while for Dedin 58900 tubes / year, Didin 59800 tubes / year, muhyidin 8700 tubes / year, suherman 77800 tubes / year, Haris 59900 tubes / year, Ujang 62500 tubes / year Irfan 53600 tube / year, while for the maman base needs lpg gas supply of 56800 tubes / year calculation of DRP needs lpg gas most is suherman base as much as 77800 tubes / year.Keywords: linear regression forecasting, DRP (Distribution Requirement Planning) gross requitment and Plannd order release
ANALISIS DAYA SERAP DAN DAYA TEKAN BATAKO PRES, TERHADAP INTERAKSI FAKTOR PEKERJA, FAKTOR KOMPOSISI AIR, DAN FAKTOR KOMPOSISI KAPUR-PASIR
Authors: Sutoni Akhmad , Gunawan Dani
Published: August 2019

Abstract— The need for building materials in recent decades has increased. One of them is the need of "Prescription Batako". This can happen along with the increasing of infrastructure development in society. As a result, the challenge of reaching market demand is also greater. This condition demands each Preservation Batako company to provide maximum product Quality. The purpose of this research is to know what factors affect the results of Prescription Batako products. The method used is a Design Experiment using Factorial Factor Three Factor. The three factors are Worker factor, water composition factor, and with sand-lime composition factor. Data processing is assisted by SPSS software. Influence which is analyzed by three factors are absorption and compressive power. These three factors have a significant effect on absorption and compressive power.Keywords— Design Experiment; Factorial Three Factor Kata kunci : Design Experiment, Faktorial Tiga Faktor
Aplikasi Pendekatan Theory of Constraints pada Maksimasi Throughput Produksi
Authors: Kristiana Leo Rama , Sunarni Theresia
Published: August 2019

PT XYZ is a manufacturing company that produces various furniture products. The company has two product categories, first category A (as standard products) with production system is make to stock the second is category B (custom products) with production system is make to order. Production time products category B is more than longer than production time product category B. Production department’s PT XYZ arise problem when face high demand. Limitations of production’s resources cause bottleneck in lines production and inability to meet demand. In addition, inaccuracies in allocating limited resources will causing descent of throughput. Optimization of limited resources needs to be done to reach the maximum throughput. This research was conducted to find out the production resources that become constraintss in fulfilling demand, the number of each type of product must be produced at the existing capacity to achieve optimal throughput and identify and analyze solutions to problems of limited production resources. The results of the study conclude that the production resources that become constraintss are man power and man hours. The maximum throughput that can be achieved by PT XYZ by optimizing the existing available resources is Rp. 819,148,490, and there are two types of products that cannot be fulfilled. Increased production capacity can be done with several alternatives, such as over time hours, out sourcing operators (freelancers), subcontracting of production, adding man power with recruitment of new operator and their combinations. The optimal throughput is Rp 1,056. 763,100 could be obtained from using alternative resource from recruiting new operator and combination with over time capacities.
ANALISIS DIMENSI KUALITAS PELAYANAN PADA PERUSAHAAN JASA PELABUHAN CURAH PT. KRAKATAU BANDAR SAMUDERA CILEGON MENGGUNAKAN METODA SERVQUAL
Authors: Subhan Ali
Published: August 2019

PT. Krakatau Bandar Samudera (Pelabuhan Cigading) adalah salah satu perusahaan jasa pelabuhan yang khusus melakukan bongkar muat barang-barang berbentuk curah. Penelitian ini bertujuan untuk menganalisis dimensi-dimensi kualitas jasa pelabuhan dalam upaya memperbaiki dan meningkatkan kualitas pelayanan yang sudah ada. Metoda yang digunakan dalam penelitian ini adalah model pengukuran kuantitatif Service Quality (Servqual method) dan Analisis Kesenjangan (Gap Analysis). Hasil penelitian menunjukkan bahwa dari 5 dimensi kualitas jasa yang terbagi kedalam 30 atribut pelayanan pada jasa pelayanan Pelabuhan Cigading terdapat 20 atribut pelayanan pelabuhan yang dianggap penting oleh konsumen. Dari Servqual Score diperoleh 11 atribut pelayanan yang memiliki nilai Servqual Score kurang dari nilai harapan konsumen, sehingga atribut-atribut tersebut harus mendapatkan prioritas utama dalam perbaikan kualitas pelayanan pelabuhan. Berdasarkan analisis Gap 5 terdapat 11 atribut pelayanan yang memiliki kesenjangan antara harapan konsumen dengan persepsi konsumen. Sedangkan berdasarkan analisis Gap 1 terdapat 7 atribut pelayanan yang memiliki kesenjangan antara haparan konsumen dengan persepsi manajemen. Secara rata-rata indeks kepuasan konsumen (Customer Satisfaction Index) bisa dikatakan cukup baik karena memiliki nilai sebesar 95,27%. Namun demikian, karena masih banyak variabel-varibel atribut pelayanan yang memiliki nilai CSI dengan kategori “kurang”, maka perlu ada pemerataan tingkat perbaikan kualitas pelayanan pada atribut pelayanan yang masih dirasakan kurang.Kata Kunci : Service Quality, Servqual Score, Gap Analysis, Customer Satisfaction Index.
Penentuan Jarak Pendistribusian Gas LPG 3 Kg Dengan Metode Algoritma Heuristik
Authors: Sutoni Akhmad , Asilah Nur
Published: August 2019

PT. Anugrah Ditamas Lestari is an agent of 3 kg LPG Gas, to distribute to bases. PT. Anugrah Ditamas Lestari has a problem in distributing 3 kg of gas to the base, so it must have good planning so that the items to be distributed can reach the base in a timely manner. Traveling Salesman Problem (TSP) is a distribution problem in the form of transportation equipment (vehicle) from the agent to the base then back to PT. Anugrah Ditamas Lestari (agent). The research conducted aims to determine the minimum mileage for each route. The preparation of this Gas distribution route was completed using the Heuristic Algorithm. The initial stage is the formation of a sub route which is the process of grouping the base into the route. The next stage of the sub route development phase that has been formed is based on the existing travel time, the last stage minimizes the distance where the agent must first deliver the product until the last base and return to the agent. Sub route formation is still done manually while to compare the final results is done using WinQSB Software. Based on this distance determination study, the distance traveled was closer, and did not come to the base twice.
Pengaruh Deposits, BOPO Dan NIM Terhadap Profit Distribution Management Pada Bank Umum Syariah Yang Terdaftar di JII Periode 2011-2014
Authors: Wat Indri Dwidya Nurmalawaty , Icih Icih , Mulyati Sri
Published: August 2019

This study aimed to analyze the factors affecting the Profit Distribution Management at Commercial Bank of sharia (BUS) in Indonesia. The dependent variable used in this study is Profit Distribution Management. Independent variables used in this study, among others Deposits, BOPO and NIM.

This study used a sample of Islamic banks listed in the Jakarta Islamic Index (JII) in the 2011-2014 period. Data were collected using the technique purposive sampling. The total sample used in this study were 8 Islamic Banks. Data analysis was performed with the classical assumption and hypothesis testing with multiple regression method.

Results from this study showed that the variables Deposits and BOPO significantly negative effect on the Profit Distribution Management, while the NIM variables do not significantly affect the distribution Profit Managemen.
PENGARUH DIVIDEN PAYOUT RATIO, FINANCIAL LEVERAGE DAN PROFITABILITAS TERHADAP BETA SAHAM
Authors: Ramadani Suci , Mulyati Sri , Icih Icih
Published: August 2019

Jakarta Islamic Index is an index comprised of stocks that meet various criteria sharia. Islamic stocks beta is a measure of the risk of the shares belonging to sharia. This study aims to examine and determine the influence of fundamental factors to Islamic stock beta.

Object of this research is the company that makes the Jakarta Islamic Index years 2011-2013, with purposive sampling technique gained 12 companies as the study sample. The independent variabel in this study is dividend payout ratio (DPR), financial leverage (FL) and profitability. This research using multiple regression analysis to test the hypotesis.

Result showed that the variables dividen payout ratio has no effect on beta Islamic stock. Variable financial leverage and profitability variables significant positive effect on beta Islamic stock. Simultaneous dividen payout ratio, financial leverage and profitability significantly to the beta having an Islamic stock
Fraksi Kloroform Ekstrak Buah Mentimun (Cucumis sativusL.) Sebagai Anti Bakteri Terhadap Staphylococcus epidermidis
Authors: User Samsuar , Viogenta Pratika , Utama Ahmad Ferry Yeriza
Published: August 2019

Penggunaan antibiotik secara besar-besaran di masyarakat memicu terjadinya resistensi terhadap bakteri, Untuk itu perlu adanya penelitian tentang alternatif lain terutama obat herbal sebagai antibakteri. Satu di antara tanaman berkhasiat obat adalah mentimun yang banyak terdapat di Indonesia.Tujuan penelitian ini adalah untuk membuktikan daya antibakteri fraksi kloroform ekstrak buah mentimun terhadap Staphylococcus epidermidis. Ekstraksi buah mentimun dilakukan dengan cara maserasi dengan etanol 70 %, selanjutnya ekstrak difraksinasi dengan kloroform. Fraksi yang digunakan adalah konsentrasi 5, 10, 15, 20, dan 25 %. Kemudian dilakukan uji daya antibakteri dan penentuan Konsentrasi Hambat Minimum. Hasil penelitian uji daya antibakteri fraksi kloroform ekstrak buah mentimun terhadap bakteri Staphylococcus epidermidis menunjukan adanya zona hambat pada konsentrasi 5, 10, 15, 20,dan25% dengan diameter masing-masing 5.86, 6.5, 7.05, 7.43 dan 9.92 mm.  Selain itu, konsentrasi hambat minimum fraksi kloroform ekstrak buah mentimun terhadap S. epidermidis terdapat pada konsentrasi 3 %. Dari hasil kultur ulang didapatkan pertumbuhan pada media Nutrient Agar yang berarti fraksi kloroform ekstrak buah mentimun pada konsentrasi 3% bersifat bakteriostatik.
Evaluasi “Sekolah Gratis” SMA/SMK di Kota Bandar Lampung
Authors: Saifuddin Ridwan
Published: August 2019

Evaluasi bertujuan untuk mengetahui pengaruh implementasi kebijakan sekolah gratis berupa program bina lingkungan dalam Penerimaan Peserta Didik Baru (PPDB) terhadap pencapaian delapan Standar Nasional Pendidikan SMA/SMK di Kota Bandar Lampung. Penelitian dilakukan dengan menggunakan pendekatan deskriptif kuantitatif. Kebijakan sekolah gratis memberikan dampak positif dan negatif terhadap satuan pendidikan di Kota Bandar Lampung. Dampak positif, khususnya dalam menyukseskan program wajib belajar, angka partisipasi sekolah, pemberantasan buta aksara, serta memberikan tantangan kepada (kepala) sekolah dan para guru dalam menghadapi peserta didik yang memiliki kemampuan akademik dan nonakademik beragam. Dampak negatifnya disebabkan belum siapnya sekolah, baik menyangkut ketersediaan sarana-prasarana pendidikan, SDM guru dan tenaga kependidikan, serta kapasitas keuangan sekolah, untuk melaksanakan proses pembelajaran yang mengakomodasi tingkat keragaman siswa yang tinggi, khususnya dalam hal kemampuan akademik.
Refleksi Keterampilan Manajerial, Komunikasi Interpersonal dan Budaya Mutu Berfokus pada Perilaku Anggota Organisasi (Organizational Citizenship Behavior)
Authors: Winata Ganjar
Published: August 2019

Tujuan penelitian adalah menentukan pengaruh langsung dari keterampilan manajerial, komunikasi interpersonal dan budaya mutu terhadap perilaku anggota organisasi pada guru sekolah dasar negeri Kabupaten Lampung Utara. Metode penelitian menggunakan pendekatan kuantitatif dengan metode survei dan teknik analisis jalur. Data dikumpulkan menggunakan kuesioner kepada 205 guru sebagai sampel dari populasi target sebanyak 419 guru. Teknik sampling menggunakan teknik acak proporsional. Analisis data menggunakan statistik deskriptif dan statistik inferensial. Hasil penelitian adalah: 1) Keterampilan manajerial, komunikasi interpersonal dan budaya mutu mempunyai pengaruh positif langsung terhadap perilaku anggota organisasi. Berdasarkan hasil perhitungan, pengaruh keterampilan manajerial, komunikasi interpersonal dan budaya mutu terhadap Organizational Citizenship Behavior (OCB) adalah 0,651. Hal ini menunjukkan bahwa 65,1 % variasi Organizational Citizenship Behavior (OCB) dipengaruhi secara langsung oleh variasi keterampilan manajerial, komunikasi interpersonal dan budaya mutu secara bersama-sama; 2) Keterampilan manajerial mempunyai pengaruh positif langsung terhadap budaya mutu. Berdasarkan hasil perhitungan variabel budaya mutu dipengaruhi secara langsung oleh variabel keterampilan manajerial sebesar 49,28 %. Jadi, untuk meningkatkan perilaku anggota organisasi, dilaksanakan dengan memperbaiki keterampilan manajerial, komunikasi interpersonal dan budaya mutu.
Q-Test (Quran Test): Sebuah Sistem Tes Kompetensi Membaca Al-Quran
Authors: Salim Bairus
Published: August 2019

Kompetensi membaca Al-Quran merupakan salah satu tolak ukur kecerdasan spiritual yang menjadi tujuan terbesar pendidikan nasional sebagaimana diamanatkan Undang-Undang Pemerintah No. 20 Tahun 2003 tentang Sistem Pendidikan Nasional. Untuk mengukur kompetensi membaca Al-Quran, diperlukan suatu sistem tes yang holistik, sistemik dan dapat dipertanggung jawabkan. Q-Test (Quran Test) dirancang untuk merespons tantangan tersebut. Q-Test merupakan sebuah sistem tes kompetensi membaca Al-Quran yang didasarkan pada prinsip-prinsip penilaian yang benar. Sebagai sebuah sistem, Q-Test memuat komponen-komponen spesifikasi sebagai berikut: (a) materi tes yang terdiri dari makhraj dan sifat huruf, tajwid, gharib, dan fasahah, ( b) bentuk tes yang mencakup tes tulis dan praktek, (c) penguji, dan (d) perlengkapan tes. Implementasi Q-Test pertama kalinya dilakukan di SMA Negeri 1 Metro. Sebagai sample, penulis memaparkan hasil Q-Test peserta didik kelas XI IPA 5. Dari 23 peserta didik muslim yang melaksanakan tes kompetensi membaca AlQuran didapatkan hasil sebagai berikut: sebanyak 7 peserta didik (30 %) mendapatkan nilai Baik, 11 peserta didik  (48%) mendapat nilai Cukup, dan 5 peserta didik (22%) mendapat nilai Kurang.