bluuebunny/crossref_metadata_2025 huggingface dataset:
Geometric Multicut: Shortest Fences for Separating Groups of Objects in the Plane
Authors: Abrahamsen Mikkel , Giannopoulos Panos , Löffler Maarten , Rote Günter
Published: August 2020

We study the following separation problem: Given a collection of pairwise disjoint coloured objects in the plane withkdifferent colours, compute a shortest “fence”F, i.e., a union of curves of minimum total length, that separates every pair of objects of different colours. Two objects are separated ifFcontains a simple closed curve that has one object in the interior and the other in the exterior. We refer to the problem asgeometrick-cut, as it is a geometric analog to the well-studied multicut problem on graphs. We first give an$$O(n^4\log ^3\!n)$$O(n4log3n)-time algorithm that computes an optimal fence for the case where the input consists of polygons of two colours withncorners in total. We then show that the problem is NP-hard for the case of three colours. Finally, we give a randomised$$4/3\cdot 1.2965$$4/3·1.2965-approximation algorithm for polygons and any number of colours.
Comparison of manual and semi-automatic registration in augmented reality image-guided liver surgery: a clinical feasibility study
Authors: Schneider C. , Thompson S. , Totz J. , Song Y. , Allam M. , Sodergren M. H. , Desjardins A. E. , Barratt D. , Ourselin S. , Gurusamy K. , Stoyanov D. , Clarkson M. J. , Hawkes D. J. , Davidson B. R.
Published: August 2020

Background

The laparoscopic approach to liver resection may reduce morbidity and hospital stay. However, uptake has been slow due to concerns about patient safety and oncological radicality. Image guidance systems may improve patient safety by enabling 3D visualisation of critical intra- and extrahepatic structures. Current systems suffer from non-intuitive visualisation and a complicated setup process. A novel image guidance system (SmartLiver), offering augmented reality visualisation and semi-automatic registration has been developed to address these issues. A clinical feasibility study evaluated the performance and usability of SmartLiver with either manual or semi-automatic registration.

Methods

Intraoperative image guidance data were recorded and analysed in patients undergoing laparoscopic liver resection or cancer staging. Stereoscopic surface reconstruction and iterative closest point matching facilitated semi-automatic registration. The primary endpoint was defined as successful registration as determined by the operating surgeon. Secondary endpoints were system usability as assessed by a surgeon questionnaire and comparison of manual vs. semi-automatic registration accuracy. Since SmartLiver is still in development no attempt was made to evaluate its impact on perioperative outcomes.

Results

The primary endpoint was achieved in 16 out of 18 patients. Initially semi-automatic registration failed because the IGS could not distinguish the liver surface from surrounding structures. Implementation of a deep learning algorithm enabled the IGS to overcome this issue and facilitate semi-automatic registration. Mean registration accuracy was 10.9 ± 4.2 mm (manual) vs. 13.9 ± 4.4 mm (semi-automatic) (Mean difference − 3 mm; p = 0.158). Surgeon feedback was positive about IGS handling and improved intraoperative orientation but also highlighted the need for a simpler setup process and better integration with laparoscopic ultrasound.

Conclusion

The technical feasibility of using SmartLiver intraoperatively has been demonstrated. With further improvements semi-automatic registration may enhance user friendliness and workflow of SmartLiver. Manual and semi-automatic registration accuracy were comparable but evaluation on a larger patient cohort is required to confirm these findings.
Segmented lordotic angles to assess lumbosacral transitional vertebra on EOS
Authors: Albano Domenico , Messina Carmelo , Gambino Angelo , Gurgitano Martina , Sciabica Carmelo , Oliveira Pavan Giordano Remo , Gitto Salvatore , Sconfienza Luca Maria
Published: August 2020

Purpose

To test the vertical posterior vertebral angles (VPVA) of the most caudal lumbar segments measured on EOS to identify and classify the lumbosacral transitional vertebra (LSTV).

Methods

We reviewed the EOS examinations of 906 patients to measure the VPVA at the most caudal lumbar segment (cVPVA) and at the immediately proximal segment (pVPVA), with dVPVA being the result of their difference. Mann–Whitney, Chi-square, and ROC curve statistics were used.

Results

172/906 patients (19%) had LSTV (112 females, mean age: 43 ± 21 years), and 89/172 had type I LSTV (52%), 42/172 type II (24%), 33/172 type III (19%), and 8/172 type IV (5%). The cVPVA and dVPVA in non-articulated patients were significantly higher than those of patients with LSTV, patients with only accessory articulations, and patients with only bony fusion (all p < .001). The cVPVA and dVPVA in L5 sacralization were significantly higher than in S1 lumbarization (p < .001). The following optimal cutoff was found: cVPVA of 28.2° (AUC = 0.797) and dVPVA of 11.1° (AUC = 0.782) to identify LSTV; cVPVA of 28.2° (AUC = 0.665) and dVPVA of 8° (AUC = 0.718) to identify type II LSTV; cVPVA of 25.5° (AUC = 0.797) and dVPVA of − 7.5° (AUC = 0.831) to identify type III–IV LSTV; cVPVA of 20.4° (AUC = 0.693) and dVPVA of − 1.8° (AUC = 0.665) to differentiate type II from III–IV LSTV; cVPVA of 17.9° (AUC = 0.741) and dVPVA of − 4.5° (AUC = 0.774) to differentiate L5 sacralization from S1 lumbarization.

Conclusion

The cVPVA and dVPVA measured on EOS showed good diagnostic performance to identify LSTV, to correctly classify it, and to differentiate L5 sacralization from S1 lumbarization.
EMAC, Retromer, and VSRs: do they connect?
Authors: Ivanov Rumen , Robinson David G.
Published: August 2020

Eukaryotic organisms share many common features in terms of endomembrane trafficking. This fact has helped plant scientists to propose testable hypotheses on how plant intracellular membrane trafficking is achieved and regulated based on knowledge from yeast and mammals. However, when a new compartment has been identified in a plant cell that has a vesicle tethering complex located at a position which is completely different to its counterpart in yeast and mammalian cells, caution is demanded when interpreting possible interactions with other trafficking elements. This is exemplified by the recently discovered EMAC (ER and microtubule-associated compartment). It has been postulated that this compartment is the recipient of vacuolar sorting receptors (VSRs) transported retrogradely via “retromer vesicles” from a post-Golgi location. Unfortunately, this suggestion was based entirely on our knowledge of retromer from yeast and mammalian cells, and did not take into account the available literature on the composition, localization, and function of the plant retromer. It also lacked reference to recent contradictory findings on VSR trafficking. In this short article, we have tried to rectify this situation, pointing out that plant retromer may not function as a pentameric complex of two subunits: the retromer core and the sorting nexins.
Using large-scale augmented floor surfaces for industrial applications and evaluation on perceived sizes
Authors: Otto Michael , Lampen Eva , Agethen Philipp , Zachmann Gabriel , Rukzio Enrico
Published: August 2020

Large high-resolution displays (LHRDs) provide an enabling technology to achieve immersive, isometrically registered, virtual environments. It has been shown that LHRDs allow better size judgments, higher collaboration performance, and shorter task completion times. This paper presents novel insights into human size perception using large-scale floor displays, in particular in-depth evaluations of size judgment accuracy, precision, and task completion time. These investigations have been performed in the context of six, novel applications in the domain of automotive production planning. In our studies, we used a 54-sqm sized LED floor and a standard tablet visualizing relatively scaled and true to scale 2D content, which users had to estimate using different aids. The study involved 22 participants and three different conditions. Results indicate that true to scale floor visualizations reduce the mean absolute percentage error of spatial estimations. In all three conditions, we did not find the typical overestimation or underestimation of size judgments.
Neuromuscular complications following targeted therapy in cancer patients: beyond the immune checkpoint inhibitors. Case reports and review of the literature
Authors: Demichelis Chiara , Balestra Andrea , Lapucci Caterina , Zuppa Angela , Grisanti Stefano G , Prada Valeria , Pesce Giampaola , Grasso Ilaria , Queirolo Paola , Schenone Angelo , Benedetti Luana , Grandis Marina
Published: August 2020

Introduction

In the last years, many new drugs have been developed targeting different oncology pathways, overall improving both quality of life and survival in several malignancies. However, the increase of those therapies is associated with novel toxicities, mainly immune-related adverse events (irAEs), never observed before. Different irAEs are now well characterized, and, among them, neuromuscular complications, following immune checkpoint inhibitor (ICPi) therapy, are increasingly studied and described. However, there are also neurological complications related to the use of other targeted therapies, less known and probably underestimated. Herein we describe two oncological patients who developed neuromuscular diseases after administration of targeted therapies, different from ICPi.

Case reports

The first patient was treated with the combination of Vemurafenib and Cobimetinib, BRAF and MEK inhibitors, respectively, for a cutaneous melanoma. One year after the beginning of the combined treatment, she developed a sub-acute motor neuropathy with predominant cranial nerve involvement. She was successfully treated with methylprednisolone. The second patient received therapy with Imatinib, tyrosine kinase inhibitor and precursor of the targeted therapy, for a gastrointestinal stromal tumour. Few days after the first administration, he developed generalized myasthenia gravis with respiratory failure. Clinical remission was obtained with plasma-exchange, intravenous immunoglobulins and steroids.

Discussion and Conclusion

We strengthen the relevance of neuromuscular complications which may occur long after treatment start or in patients receiving not only the latest ICPi but also “older” and apparently better-known targeted therapies. Also in the latter cases, an immune-mediated “off-target” pathogenic mechanism can be hypothesized, and consequences can be life threatening, if not promptly diagnosed and appropriately managed.
Automatic generation of UML profile graphical editors for Papyrus
Authors: Wei Ran , Zolotas Athanasios , Hoyos Rodriguez Horacio , Gerasimou Simos , Kolovos Dimitrios S. , Paige Richard F.
Published: August 2020

UML profiles offer an intuitive way for developers to build domain-specific modelling languages by reusing and extending UML concepts. Eclipse Papyrus is a powerful open-source UML modelling tool which supports UML profiling. However, with power comes complexity, implementing non-trivial UML profiles and their supporting editors in Papyrus typically requires the developers to handcraft and maintain a number of interconnected models through a loosely guided, labour-intensive and error-prone process. We demonstrate how metamodel annotations and model transformation techniques can help manage the complexity of Papyrus in the creation of UML profiles and their supporting editors. We presentJorvik, an open-source tool that implements the proposed approach. We illustrate its functionality with examples, and we evaluate our approach by comparing it against manual UML profile specification and editor implementation using a non-trivial enterprise modelling language (Archimate) as a case study. We also perform a user study in which developers are asked to produce identical editors using both Papyrus andJorvikdemonstrating the substantial productivity and maintainability benefits thatJorvikdelivers.
Shifting self-perceptions of ageing: differential effects of value priorities on self-perceptions of ageing beyond age stereotypes
Authors: Blawert Anne , Wurm Susanne
Published: August 2020

Self-perceptions of ageing (SPA) are important predictors of health in later life. However, research on antecedents of SPA other than age stereotypes is scarce. To address this gap, this study investigates the impact of personal value priorities beyond age stereotypes on SPA. Can values as the motivational basis of attitudes and evaluations predict gain- and loss-related SPA? To answer this question, we conducted multiple regression analyses of longitudinal data from two waves (2008, 2011) of the German Ageing Survey (DEAS;N = 6089, age range in 2008: 40–93 years). Gain- and loss-related SPA as well as age stereotypes were assessed with two AgeCog scales and personal values with the 21-item Portrait Values Questionnaire. Results indicate that value priorities relate to SPA longitudinally in domain-specific ways: People with a value priority of openness to change and self-transcendence reported more gain-related SPA at follow-up, whereas those who prioritized conservation reported less gain-related SPA. In the domain of loss-related SPA, those people with a value priority of self-enhancement reported more and those prioritizing self-transcendence reported less loss-related SPA at follow-up. These results complement and extend recent findings on the role of personality for SPA. They suggest that whether people focus on the gains or losses that occur with age, whether they perceive ageing as a threat or chance, is not only shaped by their age stereotypes, but also by what they find important—their values.
Digital Inquiry Through Games
Authors: Albano Giovannina , Arzarello Ferdinando , Dello Iacono Umberto
Published: August 2020

This paper aims to show how the Logic of Game Theory can facilitate the structuring of games for the learning of mathematical concepts, in a way which is cognitively resonant with students’ attitudes and epistemologically sound from the mathematical standpoint. We propose a kind of game, based on an inquiry approach to mathematics, called Digital Inquiry Game (DIG), the aim of which is to foster students’ positive beliefs about their mathematical capabilities with regards to problem solving and to improve the way students are able to grasp the epistemic aspects of the mathematical knowledge in question. The main issues surrounding the theoretical background and the inspiring key constructs of the DIG are explained. The design of a DIG is validated through a case study concerning some properties of integers and a general divisibility criterion. Finally, some issues for further researches are considered.
In Vitro Measurement of Strain Localization Preceding Dissection of the Aortic Wall Subjected to Radial Tension
Authors: Di Giuseppe M. , Zingales M. , Pasta S. , Avril S.
Published: August 2020

Background

Aortic dissection (AD) is a common pathology and challenging clinical problem. A better understanding of the biomechanical effects preceding its initiation is essential for predicting adverse events on a patient-specific basis. Moreover, the predictability of patient-specific biomechanics-based computational models is hampered by uncertainty about boundary conditions and material properties.

Objective

Predisposition of thoracic aortic aneurysms (TAA) to ADs can be related to the degradation of biomechanically important constituents in the aortic wall of TAAs. The goal of the present study is to develop a new methodology to measure strain fields in aortic tissues subjected to radial tensile loading, combining optical coherence tomography (OCT) and digital image correlation (DIC).

Methods

Radial tensile tests are performed on 5 samples collected from a healthy porcine descending thoracic aorta and 2 samples collected from a human ascending thoracic aortic aneurysm. At each step of the radial tensile test, the OCT technique is used to acquire images of the sample presenting a speckle pattern generated by the optical signature of the tissue. The speckle pattern is used to quantify displacement and strain fields using DIC. Stress-strain data are also measured throughout the analyzed range.

Results

Results show that strain commonly localizes very early during tensile tests, at the location where the crack onset occurs. Aneurysm samples even show a sharper localization than healthy porcine tissues.

Conclusion

This suggests the importance of extending the analysis to a larger number of human samples using our new methodology to better identify the conditions predisposing aortas to dissection.
Arbeitszeitgestaltung in der digitalisierten Arbeitswelt: Ein systematisches Literatur Review zur Wirkung von Arbeitszeitverkürzung in Bezug auf die psychische Gesundheit
Authors: Jansen-Preilowski Virgilia V. , Paruzel Agnieszka , Maier Günter W.
Published: August 2020

Dieser Beitrag der Zeitschrift Gruppe. Interaktion. Organisation. (GIO) stellt ein systematisches Review zum Zusammenhang der Arbeitszeitverkürzung (bei vollem Gehalt) und psychischen Gesundheit auf der Grundlage vorhandener Studien vor, um Chancen und Risiken besser einschätzen und beurteilen zu können. Die Diskussion über die Verkürzung von Arbeitszeiten wird nicht zuletzt durch die vielfältigen Möglichkeiten der Digitalisierung der Arbeit verstärkt. Die Literatursuche ergab insgesamt 114 Artikel, wovon drei qualitative, neun quantitative Studien und eine Mixed Method Studie in die Analyse aufgenommen wurden. Aus den Ergebnissen wurde deutlich, dass eine verkürzte Arbeitszeit bei gleichbleibendem Lohn zu einer Verringerung von arbeitsbedingten Belastungen bei Beschäftigten beitragen. Die Umsetzung der Verkürzung erfolgte auf drei unterschiedliche Weisen: I. ohne Veränderung der Arbeitsprozesse, II. ohne Veränderung der Arbeitsprozesse, jedoch mit zusätzlichen Beschäftigten oder III. mit einer vorhergehenden Veränderung der Arbeitsprozesse, ohne zusätzliche Angestellte. Zwar gibt es bis dato noch keine allgemeingültige Empfehlung für die Umsetzung in die Praxis, allerdings wird für eine erfolgreiche Umsetzung empfohlen, die Reduktion der Arbeitszeit vorab zu planen und Optimierungsmöglichkeiten für die Ausführung von Tätigkeiten und Arbeitsprozessen zu identifizieren (III.).
The Elovl4 Spinocerebellar Ataxia-34 Mutation 736T>G (p.W246G) Impairs Retinal Function in the Absence of Photoreceptor Degeneration
Authors: Agbaga Martin-Paul , Stiles Megan A. , Brush Richard S. , Sullivan Michael T. , Machalinski Adeline , Jones Kenneth L. , Anderson Robert E. , Sherry David M.
Published: August 2020

Elongation of very long chain fatty acids-4 (ELOVL4) is essential for synthesis of very long chain polyunsaturated and saturated fatty acids (VLC-PUFA and VLC-SFA, respectively) of chain length greater than 26 carbons. Mutations in the ELOVL4 gene cause several distinct neurodegenerative diseases including Stargardt-like macular dystrophy (STGD3), spinocerebellar ataxia 34 (SCA34), and a neuro-ichthyotic syndrome with severe seizures and spasticity, as well as erythrokeratitis variabilis (EKV), a skin disorder. However, the relationship between ELOVL4 mutations, its VLC-PUFA and VLC-SFA products, and specific neurological symptoms remains unclear. We generated a knock-in rat line (SCA34-KI) that expresses the 736T>G (p.W246G) form of ELOVL4 that causes human SCA34. Lipids were analyzed by gas chromatography and mass spectrometry. Retinal function was assessed using electroretinography. Retinal integrity was assessed by histology, optical coherence tomography, and immunolabeling. Analysis of retina and skin lipids showed that the W246G mutation selectively impaired synthesis of VLC-SFA, but not VLC-PUFA. Homozygous SCA34-KI rats showed reduced ERG a- and b-wave amplitudes by 90 days of age, particularly for scotopic responses. Anatomical analyses revealed no indication of neurodegeneration in heterozygote or homozygote SCA34-KI rats out to 6–7 months of age. These studies reveal a previously unrecognized role for VLC-SFA in regulating retinal function, particularly transmission from photoreceptors to the inner retina, in the absence of neurodegeneration. Furthermore, these findings suggest that the tissue specificity and symptoms associated with disease-causing ELOVL4 mutations likely arise from selective differences in the ability of the mutant ELOVL4 enzymes to support synthesis of VLC-PUFA and/or VLC-SFA.
Therapeutic options for patients with advanced atrial fibrillation: from lifestyle and medication to catheter and surgical ablation
Authors: Boersma L. , Rienstra M. , de Groot J. R.
Published: August 2020

Atrial fibrillation (AF) is part of a vicious cycle that includes multiple cardiovascular risk factors and comorbidity which can promote atrial remodelling and AF progression. Most AF-related risk factors—hypertension, diabetes, sleep apnoea, obesity and sedentary lifestyle—are in essence modifiable which may prevent AF development. Treatment of associated cardiovascular conditions may prevent both symptoms and future cardiovascular events. For advanced forms of symptomatic AF refractory to lifestyle management and optimal medication, invasive ablation therapies have become a cornerstone. Although electrical trigger isolation from the pulmonary veins is reasonably effective and safe, more potent energy sources including high output-short duration radiofrequency, ultra-low cryo-energy, and electroporation, as well as more sophisticated arrays, balloons, and lattice-tipped catheter tools, are on their way to eliminate existing pitfalls and simplify the procedure. Electroanatomical navigation and mapping systems are becoming available to provide real-time information on ablation lesion quality and the critical pathways of AF in the individual patient to guide more extensive ablation strategies that may enhance long-term outcome for freedom of advanced AF. Surgical techniques, either stand-alone or concomitant to structural cardiac repair, hybrid, or convergent, with novel less invasive access options are developing and can be helpful in situations unsuitable for catheter ablation.
The scientific basis for secondary prevention of coronary artery disease: recent contributions from the Netherlands
Authors: Jørstad H. T. , Snaterse M. , ter Hoeve N. , Sunamura M. , Brouwers R. , Kemps H. , Scholte op Reimer W. J. M. , Peters R. J. G.
Published: August 2020

While the beneficial effects of secondary prevention of cardiovascular disease are undisputed, implementation remains challenging. A gap between guideline-mandated risk factor targets and clinical reality was documented as early as the 1990s. To address this issue, research groups in the Netherlands have performed several major projects. These projects address innovative, multidisciplinary strategies to improve medication adherence and to stimulate healthy lifestyles, both in the setting of cardiac rehabilitation and at dedicated outpatient clinics. The findings of these projects have led to changes in prevention and rehabilitation guidelines.
Recent developments in diagnosis and risk stratification of non-ST-elevation acute coronary syndrome
Authors: Aarts G. W. A. , Mol J. Q. , Camaro C. , Lemkes J. , van Royen N. , Damman P.
Published: August 2020

In the past year, a number of important papers have been published on non-ST-elevation acute coronary syndrome, highlighting progress in clinical care. The current review focuses on early diagnosis and risk stratification using biomarkers and advances in intracoronary imaging.
Invasive coronary physiology: a Dutch tradition
Authors: van de Hoef T. P. , de Waard G. A. , Meuwissen M. , Voskuil M. , Chamuleau S. A. J. , van Royen N. , Piek J. J.
Published: August 2020

Invasive coronary physiology has been applied since the early days of percutaneous transluminal coronary angioplasty, and has become a rapidly emerging field of research. Many physiology indices have been developed, tested in clinical studies, and are now applied in daily clinical practice. Recent clinical practice guidelines further support the use of advanced invasive physiology methods to optimise the diagnosis and treatment of patients with acute and chronic coronary syndromes. This article provides a succinct review of the history of invasive coronary physiology, the basic concepts of currently available physiological parameters, and will particularly highlight the Dutch contribution to this field of invasive coronary physiology.
An investigation into the roles of chlorides and sulphate salts on the performance of low-salinity injection in sandstone reservoirs: experimental approach
Authors: Al-Otaibi Athari
Published: August 2020

Numerous studies have been carried out to ascertain the mechanisms of low-salinity and smart water flooding technique for improved oil recovery. Focus was often on brine composition and, specifically, the cationic content in sandstone reservoirs. Given the importance of the salt composition and concentration, tweaking the active ions which are responsible for the fluids–rock equilibrium will bring into effect numerous mechanisms of displacement which have been extensively debated. This experimental study, however, was carried out to evaluate the extent of the roles of chloride- and sulphate-based brines in improved oil recovery. To carry this out, 70,000 ppm sulphates- and chloride-based brines were prepared to simulate formation water and 5000 ppm brines of the same species as low-salinity displacement fluids. Core flooding process was used to simulate the displacement of oil by using four (4) native sandstones core samples, obtained from Burgan oil field in Kuwait, at operating conditions of 1500 psig and 50 °C. The core samples were injected with 70,000 ppm chloride and sulphates and subsequently flooded with the 5000 ppm counterparts in a forced imbibition process. Separate evaluations of chloride- and sulphate-based brines were carried out to investigate the displacement efficiencies of each brine species. The results showed that in both high- and low-salinity displacement tests, the SO4 brine presented better recovery of up to 89% of the initial oil saturation (Soi). Several mechanisms of displacement were observed to be responsible for improved recovery during SO4 brine displacement. IFT measurement experiments also confirmed that there was reduction in IFT at test conditions between SO4 brine and oil and visual inspection of the effluent showed a degree emulsification of oil and brines. Changes in pH were observed in the low-salinity flooding, and negligible changes were noticed in the high-salinity floods. These results provide an insight into the roles of chloride and sulphate ions in the design of smart “designer” water and low-salinity injection scenarios.
Simulation-based investigation of tar formation in after-treatment systems for biomass gasification
Authors: Boiger G. , Buff V. , Sharman D. , Boldrini M. , Lienhard V. , Drew D.
Published: August 2020

Even though biomass gasification remains a promising technology regarding de-centralized sustainable energy supply, its main limitations, namely the issues of unsteady operation, tar formation in after-treatment systems, and consequential high maintenance requirements, have never been fully overcome. In order to tackle the latter two deficiencies and to increase the understanding of thermodynamic and thermokinetic producer gas phase phenomena within the after-treatment zones, a numerical system dynamic model has been created. Thereby, naphthalene has been chosen to represent the behavior of tars. The model has been validated against a wide variety of measured and simulated producer gas compositions. This work particularly focuses on the investigation and minimization of tar formation within after-treatment systems at low pressures and decreasing temperatures. Model-based analysis has led to a range of recommended measures, which could reduce the formation tendency and thus the condensation of tars in those zones. These recommendations are (i) to decrease gas residence time within pipes and producer gas purification devices, (ii) to increase temperatures in low-pressure zones, (iii) to increase hydrogen to carbon ratio, and (iv) to increase oxygen to carbon ratio in the producer gas. Furthermore, the numerical model has been included in the cloud-computing platform KaleidoSim. Thus, a wider range of process parameter combinations could be investigated in reasonable time. Consequentially, a simulation-based sensitivity analysis of producer gas composition with respect to process parameter changes was conducted and the validity basis of the above recommendations was enlarged.
Valiron’s Interpolation Formula and a Derivative Sampling Formula in the Mellin Setting Acquired via Polar-Analytic Functions
Authors: Bardaro Carlo , Butzer Paul L. , Mantellini Ilaria , Schmeisser Gerhard
Published: August 2020

In this paper, we first recall some recent results on polar-analytic functions. Then we establish Mellin analogues of a classical interpolation of Valiron and of a derivative sampling formula. As consequences a new differentiation formula and an identity theorem in Mellin–Bernstein spaces are obtained. The main tool in the proofs is a residue theorem for polar-analytic functions.
Shared jurisdiction between veterinarians and aqua medicine biologists in fish health—a Norwegian model for inter-professional and cross-sectoral collaboration
Authors: Kjæmpenes Wenche M.
Published: August 2020

This article investigates, using a sociology of profession approach, why veterinarians and aqua medicine biologists share jurisdiction in fish health in Norway. I use a five-actor framework to highlight key events in the development of the Norwegian model for inter-professional and cross-sectoral collaboration in fish health. Veterinarians were initially the only profession involved in fish health. However, in the late 1980s, the Norwegian aquaculture industry suffered great losses due to significant disease outbreaks. Lack of scientific knowledge about the disease causing the outbreaks, Hitra disease, and lack of veterinary capacity to cope with the problem resulted in a situation in which veterinarians continued, as an early response to the disease, to use antibiotic-based therapies. The marine science milieu, with support from the aquaculture industry, instituted a vaccine solution to the endemic Hitra disease in 1987. This scientific breakthrough had major impacts on combatting fish diseases and on the further development of vaccines. New vaccine solutions for other diseases, such as furunculosis, were developed by international and multidisciplinary collaboration. Over a 7-year period, the use of antibiotic-based therapy was dramatically reduced. The control of fish diseases is aquaculture’s X factor, and without these vaccine solutions and regulation regimes, the story of Norwegian aquaculture could have been different. The successful development of the Hitra disease vaccine enabled the marine science milieu at the University of Bergen and the University of Tromsø to establish a new programme of education for aqua medicine biologists based on their own scientific knowledge base. However, their struggle for shared jurisdiction, including the right to prescribe veterinary medicine, lasted nearly 20 years. In 2005, veterinary legislation was amended, and in addition to medical doctors, dentists and veterinarians, aqua medicine biologists, as the fourth profession in Norway, gained the right to prescribe medical products. I argue that the experience in Norway, where professionals from two different sectors share jurisdiction and work side by side in fish health, is worth examining as a model for organizing inter-professional and cross-sectoral collaboration.
Experimental validation of computational fluid dynamics for solving isothermal and incompressible viscous fluid flow
Authors: Abali Bilen Emek , Savaş Ömer
Published: August 2020

In order to validate a computational method for solving viscous fluid flows, experiments are carried out in an eccentric cylindrical cavity showing various flow formations over a range of Reynoldsnumbers. Especially, in numerical solution approaches for isothermal and incompressible flows, we search for simple experimental data for evaluating accuracy as well as performance of the computational method. Verification of different computational methods is arduous, and analytic solutions are only obtained for simple geometries like a channel flow. Clearly, a method is expected to predict different flow patterns within a cavity. Thus, we propose a configuration generating different flow formations depending on the Reynoldsnumber and make the experimental results freely available in order to be used as an assessment criterion to demonstrate the reliability of a new computational approach.
EFFICIENT DYNAMIC HEDGING FOR LARGE VARIABLE ANNUITY PORTFOLIOS WITH MULTIPLE UNDERLYING ASSETS
Authors: Lin X. Sheldon , Yang Shuai
Published: August 2020

A variable annuity (VA) is an equity-linked annuity that provides investment guarantees to its policyholder and its contributions are normally invested in multiple underlying assets (e.g., mutual funds), which exposes VA liability to significant market risks. Hedging the market risks is therefore crucial in risk managing a VA portfolio as the VA guarantees are long-dated liabilities that may span decades. In order to hedge the VA liability, the issuing insurance company would need to construct a hedging portfolio consisting of the underlying assets whose positions are often determined by the liability Greeks such as partial dollar Deltas. Usually, these quantities are calculated via nested simulation approach. For insurance companies that manage large VA portfolios (e.g., 100k+ policies), calculating those quantities is extremely time-consuming or even prohibitive due to the complexity of the guarantee payoffs and the stochastic-on-stochastic nature of the nested simulation algorithm. In this paper, we extend the surrogate model-assisted nest simulation approach in Lin and Yang [(2020) Insurance: Mathematics and Economics, 91, 85–103] to efficiently calculate the total VA liability and the partial dollar Deltas for large VA portfolios with multiple underlying assets. In our proposed algorithm, the nested simulation is run using small sets of selected representative policies and representative outer loops. As a result, the computing time is substantially reduced. The computational advantage of the proposed algorithm and the importance of dynamic hedging are further illustrated through a profit and loss (P&L) analysis for a large synthetic VA portfolio. Moreover, the robustness of the performance of the proposed algorithm is tested with multiple simulation runs. Numerical results show that the proposed algorithm is able to accurately approximate different quantities of interest and the performance is robust with respect to different sets of parameter inputs. Finally, we show how our approach could be extended to potentially incorporate stochastic interest rates and estimate other Greeks such as Rho.
Public acceptability of nudges targeting parents and children to improve children's health outcomes: results from an online experiment
Authors: DROUIN OLIVIER
Published: August 2020

There is great potential for nudges to make gains in child health through improvement of lifestyle behaviors. In this study, I use an online sample of adults to test the acceptability of two nudges (one to address teenage smoking and the other to address pediatric obesity) when targeting one of three populations: adults, parents or children. The study shows that a majority of adult respondents would accept the use of nudges aimed at parents and children. The findings show that nudging parents or children directly has the same acceptability as nudging adults. These results suggest that when the objective of a nudge is to improve children's health, it is acceptable to target parents or children themselves. These results open the door to testing the efficacy of nudges in pediatric public health.
Killing in ‘the good old Irish fashion’? Irish revolutionary violence in context
Authors: Dolan Anne
Published: August 2020

In comparison to many parts of post-war Europe, Ireland's wars between 1919 and 1923 were not as lethal as they might have been. This article addresses some of the possible reasons why, reasons that were quite specific to the immediate Anglo-Irish context but reasons that may also have been due to broader transnational understandings of what it was to be a soldier, what it was to fight at that time. But while comparative fatality rates may leave Ireland somewhat overshadowed, this article considers what Ireland's wars still share with other conflicts and looks at some of the dimensions of Irish violence that were, irrespective of numbers killed, still fundamentally the same as violence experienced in other periods and places. Tackling some of the challenges of contemporary comparisons, the article suggests other possible comparisons ranging far beyond the inter-war period that may prove more fruitful, and asks whether the nature of violence shapes our perceptions of a conflict far more than fatality rates do.
‘Sinn Féin permits … in the heels of their shoes’: Cumann na mBan emigrants and transatlantic revolutionary exchange
Authors: Aiken Síobhra
Published: August 2020

The emigration of female revolutionary activists has largely eluded historical studies; their global movements transcend dominant national and regional conceptions of the Irish Revolution and challenge established narratives of political exile which are often cast in masculine terms. Drawing on Cumann na mBan nominal rolls and U.S. immigration records, this article investigates the scale of post-Civil War Cumann na mBan emigration and evaluates the geographical origins, timing and push-pull factors that defined their migration. Focusing on the United States in particular, it also measures the impact of the emigration and return migration of female revolutionaries – during the revolutionary period and in its immediate aftermath – on both the republican movement in Ireland and the fractured political landscapes of Irish America. Ultimately, this article argues that the cooperative transatlantic exchange networks of Cumann na mBan, and the consciously gendered revolutionary discourse they assisted in propagating in the diaspora, were integral to supporting the Irish Revolution at home and abroad.
The Situation in the People's Republic of Bangladesh/Republic of the Union of Myanmar Decision to Authorize Investigation (I.C.C.) and the Gambia V. Myanmar Order for Provisional Measures (I.C.J.)
Authors: Spadaro Alessandra
Published: August 2020

For the first time, the International Court of Justice (ICJ) and the International Criminal Court (ICC) are dealing concurrently with the same set of events, which concern the violence to which those in the group that self-identifies as the Rohingya have been subjected in Myanmar, and that has prompted their mass exodus to Bangladesh. Before both courts, proceedings are at a preliminary stage.
From Tyrannicide to Revolution: Aristotle on the Politics of Comradeship
Authors: JOCHIM JORDAN
Published: August 2020

Treatments of collective action in political science, classical Greek history, and democratic theory often focus on the episodic and public-facing dimensions of dissent. This article turns to Aristotle for an account of solidaristic political action whose scale and tempo is sometimes obscured by such engagements. RevisitingThe Athenian Constitution’s account of the tyrannicides of 514 BCE and the democratic revolution of 508/7 BCE, I argue for the centrality of comradeship to Aristotle’s discussions of these episodes. I demonstrate that Aristotle’s attention to the politics of comradeship is also legible inPolitics 5—which notes the dangers political clubs (hetaireiai) pose to tyranny—as well as Aristotle’s references to comrades (hetairoi) in theNicomacheanandEudemian Ethics.This article contributes to our understanding of the birth of Athenian democracy and how comradeship—a vice, to Aristotle, under ordinary political circumstances—becomes a virtue.
Gender, Law Enforcement, and Access to Justice: Evidence from All-Women Police Stations in India
Authors: JASSAL NIRVIKAR
Published: August 2020

Can gender-based “enclaves” facilitate women’s access to justice? I examine all-female police stations in India and test whether group-specific institutions assist victims of gender-based violenceandfemale officers in law enforcement. I create an original dataset based on Indian police reports and leverage the manner in which all-women police stations were opened in Haryana state to estimate their causal effect. The creation of enclaves in law enforcement does not increase registered crime. In fact, the intervention lowers the caseload at standard stations by justifying the deflection of gendered crimes, reduces responsibilities for policewomen, and increases travel cost for victims seeking redress. The institutions formalize the “counseling” of victims by encouraging reconciliation with abusers at the expense of arrest of suspects, and survey evidence suggests that all-women stations might not be associated with positive perceptions of policewomen. Broadly, I argue that representation as separation may have unintended consequences.
DEFICIENT VIRTUE IN THE PHAEDO
Authors: Reed Doug
Published: August 2020

Plato seems to have been pessimistic about how most people stand with regard to virtue. However, unlike the Stoics, he did not conclude that most people are vicious. Rather, as we know from discussions across several dialogues, he countenanced decent ethical conditions that fall short of genuine virtue, which he limited to the philosopher. Despite Plato's obvious interest in this issue, commentators rarely follow his lead by investigating in detail such conditions in the dialogues. When scholars do investigate what kind of virtue, if any, Plato thinks is open to non-philosophers, they typically look to the Republic. But in the Republic Plato sets out an ideal city; therefore, the virtue available to non-philosophers there is likely different from what he thinks is available to them in the real world. If we want to determine Plato's thoughts about the virtue of actual non-philosophers, we must look elsewhere. In this paper, I set my sights on the Phaedo.
Seroepidemiological evidence for Taenia solium taeniasis/cysticercosis in three Venezuelan rural communities
Authors: Cortez A M.M. , Rojas G. , Aguilar C.M. , Ferrer E. , Alviarez Y. , Méndez C. , Medina-Freites C. , Parkhouse R.M.E.
Published: August 2020

Taenia solium is the most common parasite infection of the brain, causing neurocysticercosis and typically found in rural communities with free-ranging pigs. Identification of transmission in rural areas is essential for its control. Risk factors and transmission of the parasite were evaluated in three rural Venezuelan communities (Valle del Rio and Potrero Largo, Cojedes state; and Palmarito, Portuguesa state) by a questionnaire (112 households) and coprological (492 samples) and serological (433 human and 230 porcine sera) analysis, respectively. Typical risk factors were found in all three communities: free-foraging pig husbandry, deficient sanitary conditions, high open defecation and ignorance of the parasite life cycle. Coprological examinations revealed a high level of soil-transmitted parasites. Importantly, two T. solium adult worm carriers were identified in each of the three communities. Anti-metacestode antibodies and the HP10 secreted metacestode glycoprotein were detected at significant levels in human and porcine sera in Valle del Rio, Potrero Largo and Palmarito. In conclusion, these communities may be considered to be endemic for taeniasis/cysticercosis, and the instigation of an appropriate control programme is recommended.
‘Too many BeEPs in our teens!’ Behavioral and emotional problems in a large group of Italian adolescents
Authors: Lisi Giulia , Rossi Rodolfo , Ribolsi Michele , Di Lorenzo Giorgio , Parisi Carla , Siracusano Martina , Morciano Laura , De Stefano Alberto , Pesaresi Alessia , Niolu Cinzia , Palombi Leonardo , Siracusano Alberto
Published: August 2020

Background

One in six adolescents suffers from mental health problems. Despite the presence of general information on Italian adolescents' mental health, researches conducted with standardized assessment tools are scarce in the literature. We evaluated the prevalence of self-reported behavioral and emotional problems in a group of Italian adolescents and examined their relation to socio-demographical variables.

Methods

This population-based sampling survey was conducted on high school students aged 14–18 from urban areas of Rome and Latina. Participants completed Youth Self-Report (YSR) and a socio-demographic schedule to collect information on age, gender, type of school attended, socio-economic status, urbanicity.

Results

Final sample consisted of 1400 adolescents (38.61% male, mean age 16 years,s.d.1.42). Prevalence of Internalizing Problems, Externalizing Problems and Total Problems was 29.55%, 18.34% and 24.13%. In our multivariable model, Internalizing Symptoms were not explained by sociodemographic variables while Externalizing Symptoms were explained by Male Gender [OR = 1.53 (1.14–2.06)], older age [OR = 2.06 (1.52–2.79)] and attending a Technical and Professional Institute [OR = 2.15 (1.53–3.02)], with an adjustedR2= 4.32%. Total Problems were explained by School Type [Technical and Professional Institutes and Art and Humanitiesv.Grammar and Science School; OR respectively 1.93 (1.40–2.67) and 1.64 (1.08–2.47)], adjustedR2= 1.94.

Conclusions

The study provides, for the first time, evidence of a great prevalence of self-reported behavioral and emotional problems in a large sample of Italian adolescents, highlighting the role of different socio-demographic variables as risk factors for externalizing behaviors. Our results emphasize the urgent need for implementing prevention programs on mental health in adolescence.
Word reading in English and Arabic in children who are Syrian refugees
Authors: Gottardo Alexandra , Amin Norah , Amin Asma , Al-Janaideh Redab , Chen Xi , Paradis Johanne
Published: August 2020

Word reading is a fundamental skill in reading and one of the building blocks of reading comprehension. Theories have posited that for second language (L2) learners, word reading skills are related if the children have sufficient experience in the L2 and are literate in the first language (L1). The L1 and L2 reading, phonological awareness skills, and morphological awareness skills of Syrian refugee children who speak Arabic and English were measured. These children were recent immigrants with limited L2 skills and varying levels of L1 education that was often not commensurate with their ages. Within- and across-language skills were examined in 96 children, ages 6 to 13 years. Results showed that phonological awareness and morphological awareness were strong within-language variables related to reading. Additionally, Arabic phonological awareness and morphological processing were strongly related to English word reading. Commonality analyses for variables within constructs (e.g., phonological awareness, morphological awareness) but across languages (Arabic and English) in relation to English word reading showed that in addition to unique variance contributed by the variables, there was a high degree of overlapping variance.