bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical evaluation of a fully automated and high-throughput molecular testing system for detection of influenza virus
Authors: Kosai Kosuke , Kaku Norihito , Horie Michiko , Kodama Hina , Akamatsu Norihiko , Narita Yusuke , Matsumoto Yasushi , Matsushita Tetsuro , Mizuta Yohei , Izumikawa Koichi , Mukae Hiroshi , Yanagihara Katsunori
Published: November 2022

Introduction

We investigated the performance of the cobas® 6800 system and cobas SARS-CoV-2 & Influenza A/B, a fully automated molecular testing system for influenza viruses and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This enabled an assay in a batch of 96 samples in approximately 3 h.

Methods

An assay was performed using the cobas SARS-CoV-2 & Influenza A/B on the cobas 6800 system for samples collected in four facilities between November 2019 and March 2020 in our previous study. The results were compared with those obtained using the reference methods.

Results

Of the 127 samples analyzed, the cobas SARS-CoV-2 & Influenza A/B detected influenza A virus in 75 samples, of which 73 were positive using the reference methods. No false negative results were observed. The overall positive and negative percent agreement for influenza A virus detection were 100.0% and 96.3%, respectively. There were no positive results for the influenza B virus or SARS-CoV-2.

Conclusion

The cobas 6800 system and cobas SARS-CoV-2 & Influenza A/B showed high accuracy for influenza A virus detection and can be useful for clinical laboratories, especially those that routinely assay many samples.
Effectiveness of Anapana, Body scan and Metta meditation techniques on chronic neck and shoulder region pain and disability in adult patients in Sri Lanka: study protocol for a cluster clinic-level randomised controlled trial
Authors: Karunanayake Aranjan Lionel , Solomon-Moore Emma , Coghill Nikki
Published: November 2022

Background

Chronic neck and shoulder region pain affects many people around the world. This study aims to compare the effectiveness of three 8-week meditation training programmes (each using a different meditation technique: Anapana, Body scan or Metta) on pain and disability in a patient population affected with chronic neck and shoulder region pain, with a usual care control group and with each other.

Methods

This four-arm parallel clinic-level randomised controlled trial will be conducted with male and female patients aged 18–65 years, who are affected with chronic neck and shoulder region pain, and who attend one of four clinics held on four different days of the week in a single medical centre in the Colombo North region, Sri Lanka. Clinics will be considered as clusters and randomly allocated to intervention and control arms.

Data will be collected using validated questionnaires, clinical examinations and focus groups. To compare primary (differences in changes in pain (Numeric Pain Rating Scale) at 8 weeks) and secondary (differences in changes in pain, physical disability, range of movement and quality of life (SF-36) at 4 and 12 weeks) outcomes between groups, a two-way ANOVA will be used if data are normally distributed. If data are not normally distributed, a nonparametric equivalent (Kruskal-Wallis) will be used. Focus group transcriptions will be thematically analysed using the Richie and Spencer model of qualitative data analysis.

Discussion

This is a four-arm trial which describes how three different 8-week meditation technique (Anapana, Body Scan, Metta) interventions will be implemented with adult patients affected with chronic neck and shoulder region pain. The effectiveness of each meditation intervention on the pain, physical and psychosocial disabilities of patients will be compared between groups and with a usual care control group. The results of this study will contribute to recommendations for future meditation interventions for chronic neck and shoulder pain.

Trial registration

ISRCTN12146140. Registered on 20 August 2021.
Sarcoma classification by DNA methylation profiling in clinical everyday life: the Charité experience
Authors: Roohani Siyer , Ehret Felix , Perez Eilís , Capper David , Jarosch Armin , Flörcken Anne , Märdian Sven , Zips Daniel , Kaul David
Published: November 2022

Background

Sarcomas are a heterogeneous group of rare malignant tumors with more than 100 subtypes. Accurate diagnosis remains challenging due to a lack of characteristic molecular or histomorphological hallmarks. A DNA methylation-based tumor profiling classifier for sarcomas (known as sarcoma classifier) from the German Cancer Research Center (Deutsches Krebsforschungszentrum) is now employed in selected cases to guide tumor classification and treatment decisions at our institution. Data on the usage of the classifier in daily clinical routine are lacking.

Methods

In this single-center experience, we describe the clinical course of five sarcoma cases undergoing thorough pathological and reference pathological examination as well as DNA methylation-based profiling and their impact on subsequent treatment decisions. We collected data on the clinical course, DNA methylation analysis, histopathology, radiological imaging, and next-generation sequencing.

Results

Five clinical cases involving DNA methylation-based profiling in 2021 at our institution were included. All patients’ DNA methylation profiles were successfully matched to a methylation profile cluster of the sarcoma classifier’s dataset. In three patients, the classifier reassured diagnosis or aided in finding the correct diagnosis in light of contradictory data and differential diagnoses. In two patients with intracranial tumors, the classifier changed the diagnosis to a novel diagnostic tumor group.

Conclusions

The sarcoma classifier is a valuable diagnostic tool that should be used after comprehensive clinical and histopathological evaluation. It may help to reassure the histopathological diagnosis or indicate the need for thorough reassessment in cases where it contradicts previous findings. However, certain limitations (non-classifiable cases, misclassifications, unclear degree of sample purity for analysis and others) currently preclude wide clinical application. The current sarcoma classifier is therefore not yet ready for a broad clinical routine. With further refinements, this promising tool may be implemented in daily clinical practice in selected cases.
Attitudes about involvement in hypothetical clinical trial protocols in Mexican and Mexican-American at risk for autosomal dominant Alzheimer’s disease
Authors: Zuno-Reyes Angélica , Matute Esmeralda , Ernstrom Karin , Withers Mellissa , Rodriguez-Agudelo Yaneth , Raman Rema , Ringman John M.
Published: November 2022

Background

The enrollment into clinical trials of persons at risk for autosomal dominant Alzheimer’s disease (ADAD) in whom the onset of disease can be accurately predicted facilitates the interpretation of outcomes (e.g., biomarkers, treatment efficacy). Attitudes toward involvement in such studies are biased by intrinsic cultural and social characteristics. Our objective was to study how demographic factors such as country of residence, age, sex, schooling, parenthood, and urbanization affect attitudes towards participation in hypothetical clinical trials in Mexican families at risk for ADAD living either in Mexico or in the United States.

Methods

Participants were 74 members of different families known to harbor an ADAD mutation living in Mexico (n = 50) or in the United States (n = 24). Participants were asked, in a written questionnaire, their interest in participating in four hypothetical clinical trial scenarios of increasing perceived invasiveness. The questionnaire then asked about their willingness should there be a 50% chance of being assigned to a placebo group. The influences of demographic variables on decisions were performed using Wilcoxon rank-sum for continuous variables and Fisher’s exact test for categorical variables.

Results

Participants who live in Mexico, who have or plan to have children, who do not attend or do not plan to attend school, and who live in rural areas gave more positive responses regarding their willingness to participate compared to those living in the U.S. The 50% chance of being in a placebo group increased the willingness to participate for family members living in Mexico. The main reason for participation was to help future generations, while the main reasons for refusal were not wanting to undergo genetic testing and consideration of adverse effects.

Conclusions

We found a higher level of willingness to participate in clinical trials among persons living in rural Mexico and our data suggest that altruism towards future generations is a major motivation, though this was balanced against concerns regarding side effects. Our results emphasize the importance of sharing information and assessing its understanding in potential participants with diverse backgrounds in the nature of ADAD and regarding the design of clinical trials prior to their enrollment in such studies.
Prevalence and incidence of carbapenem-resistant K. pneumoniae colonization: systematic review and meta-analysis
Authors: Tesfa Tewodros , Mitiku Habtamu , Edae Mekuria , Assefa Nega
Published: November 2022

Background

Klebsiella pneumoniae is a gram-negative rod belonging to the order Enterobacterales and having a wide distribution in the environment, including the human colon. Recently, the bacterium is one of the known problems in the healthcare setting as it has become resistant to last-resort drugs like carbapenems. The colonized person can serve as a reservoir for his/herself and others, especially in the healthcare setting leading to nosocomial and opportunistic infections. Therefore, we aimed to quantitatively estimate the rate of prevalence and incidence of colonization with carbapenem-resistant K. pneumoniae.

Methods

A literature search was conducted on PubMed/MEDLINE, Google Scholar, Science Direct, Cochrane Library, WHO Index Medicus, and university databases. The study includes all published and unpublished papers that addressed the prevalence or incidence of K. pneumoniae colonization. Data were extracted onto format in Microsoft Excel and pooled estimates with a 95% confidence interval calculated using Der-Simonian-Laird random-effects model. With the use of I2 statistics and prediction intervals, the level of heterogeneity was displayed. Egger’s tests and funnel plots of standard error were used to demonstrate the publication bias.

Results

A total of 35 studies were included in the review and 32 records with 37,661 patients for assessment of prevalence, while ten studies with 3643 patients for incidence of colonization. The prevalence of carbapenem-resistant K. pneumoniae colonization varies by location and ranges from 0.13 to 22%, with a pooled prevalence of 5.43%. (3.73–7.42). Whereas the incidence of colonization ranges from 2 to 73% with a pooled incidence of 22.3% (CI 12.74–31.87), both prevalence and incidence reports are majorly from developed countries. There was a variation in the distribution of carbapenem resistance genes among colonizing isolates with KPC as a prominent gene reported from many studies and NDM being reported mainly by studies from Asian countries. A univariate meta-regression analysis indicated continent, patient type, study design, and admission ward do not affect the heterogeneity (p value>0.05).

Conclusion

The review revealed that colonization with K. pneumoniae is higher in a healthcare setting with variable distribution in different localities, and resistance genes for carbapenem drugs also have unstable distribution in different geographic areas.
Infinitely many solutions for a class of fractional Schrödinger equations with sign-changing weight functions
Authors: Chen Yongpeng , Jin Baoxia
Published: November 2022

In this paper, we study the fractional Schrödinger equation $$ \textstyle\begin{cases} (-\Delta )^{s}u+u=a(x) \vert u \vert ^{p-2}u+b(x) \vert u \vert ^{q-2}u, \\ u\in H^{s}(\mathbb{R}^{N}), \end{cases} $$

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is the fractional critical Sobolev exponent. The weight potentials a or b is a sign-changing function and satisfies some valid assumptions. We obtain the existence of infinitely many solutions to the problem by the Nehari manifold.
Medical care-seeking patterns among women with menstrual syndromes-related diagnoses: a longitudinal population-based study
Authors: Guo Jong-Long , Lee Tzu-Chi , Lin Fen-He , Hsu Hsiao-Pei , Huang Chiu-Mieh
Published: November 2022

Background

Many women experience menstruation-related health issues during their child-bearing years. This study aimed to evaluate women’s tendency to seek Traditional Chinese Medicine (TCM) and/or Western Medicine (WM) when newly diagnosed with menstrual syndromes and to identify factors associated with their medical care-seeking behaviors.

Methods

The data of a total of 47,097 women aged between 15 and 50 years with newly diagnosed menstrual syndromes in 2005 were extracted from the Taiwan National Health Insurance Database. The follow-up period was divided equally into 6 month segments over 5 years starting with patients’ first visit for obstetric/gynecologic care. Outcomes were outpatient visits and number of TCM or WM visits during each period. Patients’ tendency for medical care utilization was estimated using Poisson regression analysis.

Results

Number of outpatient visits using TCM was 0.62 (29187/47097), and using WM was 1.67 (78697/47097) within 6 months after the first menstrual syndrome diagnosis. The tendency for TCM utilization increased as follow-up time increased after controlling for potential confounders, while WM utilization decreased as follow-up time increased. Age, economic status, infertility, value of prevention, baby delivery, and obstetric/gynecologic inpatient histories were significantly associated with patients’ medical care-seeking behaviors.

Conclusions

TCM and WM medical care-seeking patterns are significantly different among women with diagnoses associated with menstrual syndromes. Related factors affecting medical care-seeking behavior include age, economic status, infertility, value of prevention, childbirth and Ob/Gyn inpatient histories.
The importance of being the HGNC
Authors: Bruford Elspeth A. , Braschi Bryony , Haim-Vilmovsky Liora , Jones Tamsin E. M. , Seal Ruth L. , Tweedie Susan
Published: November 2022

The HUGO Gene Nomenclature Committee (HGNC) has been providing standardized symbols and names for human genes since the late 1970s. As funding agencies change their priorities, finding financial support for critical biomedical resources such as the HGNC becomes ever more challenging. In this article, we outline the key roles the HGNC currently plays in aiding communication and the need for these activities to be maintained.
Differential upregulation of AU-rich element-containing mRNAs in COVID-19
Authors: Bakheet Tala , Khabar Khalid S. A. , Hitti Edward G.
Published: November 2022

Background

AU-rich elements (AREs) are located in the 3′UTRs of 22% of human mRNAs, including most transiently expressed inflammatory mediators. By default, AREs mark mRNAs for decay and translational inhibition, but this activity can be temporarily inhibited in case of infection to allow the onset of inflammation. Morbidity and mortality in COVID-19 patients have been associated with dysregulated inflammation, a process that may include aberrant ARE activity.

Results

RNA-seq data from available transcriptomic studies were analyzed to investigate a possible differential expression of mRNAs that contain AREs in the context of SARS-CoV-2 infections. ARE-mRNAs turned out to be significantly overrepresented among the upregulated mRNAs after SARS-CoV-2 infection (up to 42%). In contrast, ARE-mRNAs were underrepresented (16%) in the downregulated group. Consequently, at a global scale, ARE-mRNAs are significantly more upregulated after SARS-CoV-2 infection compared to non-ARE mRNAs. This observation was apparent in lung cell line models such as A549 and Calu-3 and with infections with other respiratory viruses and cell lines. Most importantly, at the clinical level, the elevated ARE-mRNA response appeared strongest in blood cells of COVID-19 patients with mild disease. It diminished with disease severity and was least apparent in patients in need of intubation and respiratory-related death. Gene function and clustering analysis suggest that the ARE-response is rather global and the upregulated ARE-mRNAs in patients with mild disease do not particularly cluster in specific functional groups.

Conclusions

Compared to the rest of the transcriptome, ARE-containing mRNAs are preferentially upregulated in response to viral infections at a global level. In the context of COVID-19, they are most upregulated in mild disease. Due to their large number, their levels measured by RNA-seq may provide a reliable indication of COVID-19 severity.
Conceptualizing eating disorder recovery research: Current perspectives and future research directions
Authors: Hower Heather , LaMarre Andrea , Bachner-Melman Rachel , Harrop Erin N. , McGilley Beth , Kenny Therese E.
Published: November 2022

Background

How we research eating disorder (ED) recovery impacts what we know (perceive as fact) about it. Traditionally, research has focused more on the “what” of recovery (e.g., establishing criteria for recovery, reaching consensus definitions) than the “how” of recovery research (e.g., type of methodologies, triangulation of perspectives). In this paper we aim to provide an overview of the ED field’s current perspectives on recovery, discuss how our methodologies shape what is known about recovery, and suggest a broadening of our methodological “toolkits” in order to form a more complete picture of recovery.

Body

This paper examines commonly used methodologies in research, and explores how incorporating different perspectives can add to our understanding of the recovery process. To do this, we (1) provide an overview of commonly used methodologies (quantitative, qualitative), (2) consider their benefits and limitations, (3) explore newer approaches, including mixed-methods, creative methods (e.g., Photovoice, digital storytelling), and multi-methods (e.g., quantitative, qualitative, creative methods, psycho/physiological, behavioral, laboratory, online observations), and (4) suggest that broadening our methodological “toolkits” could spur more nuanced and specific insights about ED recoveries. We propose a potential future research model that would ideally have a multi-methods design, incorporate different perspectives (e.g., expanding recruitment of diverse participants, including supportive others, in study co-creation), and a longitudinal course (e.g., capturing cognitive and emotional recovery, which often comes after physical). In this way, we hope to move the field towards different, more comprehensive, perspectives on ED recovery.

Conclusion

Our current perspectives on studying ED recovery leave critical gaps in our knowledge about the process. The traditional research methodologies impact our conceptualization of recovery definitions, and in turn limit our understanding of the phenomenon. We suggest that we expand our range of methodologies, perspectives, and timeframes in research, in order to form a more complete picture of what is possible in recovery; the multiple aspects of an individual’s life that can improve, the greater number of people who can recover than previously believed, and the reaffirmation of hope that, even after decades, individuals can begin, and successfully continue, their ED recovery process.
Predictors and Hospital Outcomes in Pregnant Patients Undergoing Extracorporeal Membrane Oxygenation: A Nationwide Study
Authors: van den Bosch Oscar F. C. , Chaudhry Rabail , Wicker James , Mubashir Talha , Limb Daniel , Jogendran Rohit , Munshi Laveena , Balki Mrinalini
Published: November 2022

BACKGROUND:

Extracorporeal membrane oxygenation (ECMO) is increasingly used in patients with severe cardiorespiratory collapse. Although prior large database reviews of ECMO use in the peripartum population exist, they do not stratify by ECMO indication nor do they include obstetric conditions such as preeclampsia. Our objective was to characterize the incidence, indication-associated mortality, and factors associated with mortality in pregnant patients who underwent ECMO.

METHODS:

We examined the United States National Inpatient Sample database to identify hospitalizations for pregnancy from January 1, 2010 to December 31, 2016. We identified pregnant patients who underwent ECMO using International Classification of Diseases ninth and tenth revisions codes. The primary outcome was in-hospital all-cause mortality across pregnant patients who underwent ECMO for any indication. We evaluated the indication for ECMO, incidence, prevalence of risk factors, comorbidities and conditions, and their association with in-hospital mortality.

RESULTS:

Fifty-nine of 5‚346,517 pregnant patients underwent ECMO during our study period (incidence, 1.1; 95% confidence interval [CI], 0.84–1.4 per 100,000 hospitalizations). Indications for ECMO support included respiratory failure (79.7%), cardiogenic shock (64.4%), or circulatory arrest (25.4%). Most patients (57.6%) had more than 1 indication. The overall in-hospital mortality rate was 30.5%. Mortality was 29.8% in patients with respiratory failure, 39.5% with cardiogenic shock, 46.7% with cardiac arrest, and 42.4% in those with combined diagnoses. Cardiogenic shock was associated with a significantly higher mortality rate and adjusted odds ratio 5.0 (95% CI, 1.25–27.0). Most patients (62.7%) had one or more comorbidities.

CONCLUSIONS:

The frequency of ECMO use across the pregnant population was low over this time period, with a mortality rate of 1 in 3 patients. Mortality was greatest in patients with cardiogenic shock. Further work is needed to understand how best to improve ECMO outcomes in pregnant patients.
The Dream of Property: Law and Environment in William T. Vollmann’s Dying Grass and Leslie Marmon Silko’s Almanac of the Dead
Authors: Hamilton Ted
Published: November 2022

This article describes how the law inflects the narration of environmental conflict in William T. Vollmann’s Dying Grass (2015) and Leslie Marmon Silko’s Almanac of the Dead (1991). By focusing on the legal common sense of settler colonialism—its emphasis on private property in land and its subjugation of Indigenous peoples to the guardianship of the state—the article explores the ways in which Vollmann’s and Silko’s novels present counternarratives to the law’s story of justified conquest. Combining a law and literature approach with ecocriticism, this article highlights the importance of the legal imagination in defining human-land relations in the United States. It demonstrates how The Dying Grass and Almanac of the Dead critique this legal imagination while also using it as a model for changing environmental politics through discourse.
The Wandering Children of Mexico: Sixteenth-Century Colegios for Mestizos
Authors: Benton Bradley
Published: November 2022

Children with one Spanish and one Indigenous parent (called mestizos in subsequent generations), particularly from the lower levels of society, were viewed as problematic in the first decades of Spanish rule in New Spain. By the 1550s, colegios had been established to house and educate them. This article examines official discourses surrounding early mestizos and their colegios and their place within Novohispanic society. While documents produced by royal and church officials form an important share of the primary sources used in the study, the author also examines more mundane documents related to the colegios produced by Mexico City’s notaries from the 1550s to the 1570s. The notarial documents demonstrate that these institutions were important to Mexico City residents both rich and poor, both white and non-white.
Remarkable improvement in detection of readthrough downstream-of-gene transcripts by semi-extractable RNA-sequencing
Authors: Iwakiri Junichi , Tanaka Kumiko , Chujo Takeshi , Takakuwa Hiro , Yamazaki Tomohiro , Terai Goro , Asai Kiyoshi , Hirose Tetsuro
Published: November 2022

The mammalian cell nucleus contains dozens of membrane-less nuclear bodies that play significant roles in various aspects of gene expression. Several nuclear bodies are nucleated by specific architectural noncoding RNAs (arcRNAs) acting as structural scaffolds. We have reported that a minor population of cellular RNAs exhibits an unusual semi-extractable feature upon using the conventional procedure of RNA preparation and that needle shearing or heating of cell lysates remarkably improves extraction of dozens of RNAs. Because semi-extractable RNAs, including known arcRNAs, commonly localize in nuclear bodies, this feature may be a hallmark of arcRNAs. Using the semi-extractability of RNA, we performed genome-wide screening of semi-extractable long noncoding RNAs to identify new candidate arcRNAs for arcRNA under hyperosmotic and heat stress conditions. After screening stress-inducible and semi-extractable RNAs, hundreds of readthrough downstream-of-gene (DoG) transcripts over several hundreds of kilobases, many of which were not detected among RNAs prepared by the conventional extraction procedure, were found to be stress-inducible and semi-extractable. We further characterized some of the abundant DoGs and found that stress-inducible transient extension of the 3′-UTR made DoGs semi-extractable. Furthermore, they were localized in distinct nuclear foci that were sensitive to 1,6-hexanediol. These data suggest that semi-extractable DoGs exhibit arcRNA-like features and our semi-extractable RNA-seq is a powerful tool to extensively monitor DoGs that are induced under specific physiological conditions.
Κατασκευή ασαφών συνδέσμων και εφαρμογές στην τεχνητή νοημοσύνη
Authors: Μακαριάδης Στέφανος
Published: November 2022

Η ασαφής λογική, τις τελευταίες δεκαετίες, έχει εξελιχθεί σε ένα από τα πιο επιδραστικά επιστημονικά πεδία. Σε κάποιο βαθμό, αυτό οφείλεται στις εφαρμογές που έχουν αντίκτυπο στην καθημερινή ζωή των ανθρώπων παγκοσμίως. Η θεωρία των ασαφών συνδέσμων έχει εφαρμοστεί σε πολλά προβλήματα και πεδία. Υπάρχουν πολλές στρατηγικές για την παραγωγή ασαφών συνδέσμων. Λαμβάνοντας υπόψη το δεδομένο αυτό ο πρώτος στόχος αυτής της έρευνας είναι να παράσχει μια νέα στρατηγική για τη γενίκευση των ασαφών συνδέσμων η οποία να είναι πιο ευέλικτη και γρήγορη σε σύγκριση με τις υπόλοιπες. Για να δημιουργηθεί αυτή η μέθοδος, χρησιμοποιήθηκαν συναρτήσεις αυτομορφισμού και γεννήτριες προσθέτων. Οι γενικοί τύποι που δημιουργούνται με αυτή τη μέθοδο παρέχουν νέους ασαφείς συνδέσμους, οι οποίοι κατασκευάζονται ταχύτερα και με μεγαλύτερη ευελιξία με τη συγκεκριμένη στρατηγική. Ο δεύτερος στόχος αυτής της έρευνας είναι η παρουσίαση μιας νέας γενέτειρας ασαφών συνεπαγωγών μέσω ισχυρών ασαφών αρνήσεων, σε συνδυασμό με τις γνωστές γνήσιες ασαφείς συζεύξεις. Οι τελικές παραμετρικές συνεπαγωγές που προκύπτουν, δεδομένου ότι έχουν διαμορφωθεί με τον κατάλληλο κώδικα, επιλέγουν την καλύτερη τιμή της παραμέτρου και τον καλύτερο συνδυασμό των ασαφών συζεύξεων. Η επιλογή αυτή γίνεται μετά τη σύγκρισή τους με την εμπειριστική συνεπαγωγή, η οποία δημιουργήθηκε με τη βοήθεια πραγματικών δεδομένων θερμοκρασίας και υγρασίας από την Εθνική Μετεωρολογική Υπηρεσία (Ε.Μ.Υ.). Η χρήση της εμπειριστικής συνεπαγωγής βασίζεται σε πραγματικά δεδομένα και μειώνει τον όγκο των δεδομένων χωρίς να τα ακυρώνει. Ένας ακόμη στόχος αυτής της έρευνας είναι η εστίαση στις εφαρμογές που έχει η ασαφής λογική στη μελέτη του κλίματος. Ειδικότερα, διερευνάται εάν οι ασαφείς συνεπαγωγές μπορούν να επικυρώσουν τις κλιματικές τηλεσυνδέσεις που παρατηρούνται στα κλιματικά δεδομένα. Για την επίτευξη αυτού του στόχου, παρέχεται μια μελέτη περίπτωσης πραγματικού κόσμου που εστιάζει στη σχέση μεταξύ των ανωμαλιών θερμοκρασίας που παρατηρούνται σε διαφορετικές ευρωπαϊκές πόλεις. Τα συμπεράσματα που εξάγονται είναι ότι η ασαφής λογική μπορεί να βοηθήσει στην απόδειξη φαινομένων τα οποία, μέχρι τώρα, ερευνώνται μόνο πειραματικά.
Application of Photothermal and Photoacoustic Spectroscopy for the Monitoring of Aqueous Dispersions of Carbon Nanomaterials
Authors: Volkov D.S. , Proskurnin M.A. , Mikheev I.V. , Vasil’ev D.V. , Korobov M.V. , Nedosekin D.A. , Zharov V.P.
Published: November 2022

Photothermal  and  optoacoustic  spectroscopy  in their  state-of-the-art  techniques—multiwavelength, scanning  and  transient—are  used  for  complex investigation  and analysis  (chemical  analysis  and the  estimation  of  physicochemical  properties and size)  of  novel  carbon  materials—fullerenes  and nanodiamonds—and  their aqueous  dispersions  as promising biomedical nanosystems. The estimation of the cluster size and the possibilities to determine subnanogram  amounts  of  both nanodiamonds  and fullerenes  by  these  techniques  are  shown.  The comparison  of fullerene  solutions  in  various solvents,  toluene, N-methylpyrrolydone and  water, is made.  The  advantages  of  the  photothermal  and optoacoustic  techniques  over conventional spectroscopies  and  the  current  limitation  are discussed. The necessity to develop robust  models for  transient  and  imaging  photothermal  techniques is outlined.
Environmental Uncertainty as a Moderator of Entrepreneurship Orientation and Innovation Capability during the Pandemic: A Case of Written Batik SMEs in Yogyakarta
Authors: Utomo Humam Santosa , Susanta Susanta
Published: November 2022

Background: Written batik is one of Indonesia's cultural heritages that must be preserved. During the Covid-19 pandemic, written batik producers in Indonesia experienced increasing challenges due to the uncertainty of the business environment. Innovation is a solution to the problems faced by SMEs during a pandemic to survive. This study aims to examine the effect of entrepreneurship orientation on innovation capability. This study also examines the role of moderating environmental uncertainty in strengthening the effect of entrepreneurship orientation on innovation capability.

Methods: The research was conducted at the centre of small and medium-sized batik companies Giriloyo, Bantul, Yogyakarta, Indonesia. Respondents of this study were 130 small and medium companies selected by random sampling. The questionnaire is used as a primary data collection tool. WarpPLS has been used to analyze the effect between variables in this study.

Results: Entrepreneurship orientation is an important aspect in improving the innovation capabilities of SMEs. Environmental uncertainty during the COVID-19 pandemic has strengthened the effect of entrepreneurship orientation on innovation capabilities.

Conclusions: The findings of this study indicate that entrepreneurship orientation has a significant effect on innovation capabilities. Environmental uncertainty significantly strengthens the effect of entrepreneurship orientation on innovation capability.
Czy społeczeństwo może być sprawiedliwe? F. A. Hayek o pojęciu “sprawiedliwości społecznej”
Authors: Saar Marcin
Published: November 2022

Tematem tekstu jest F.A. Hayeka krytyka pojęcia “sprawiedliwości społecznej” czy “dystrybutywnej”, sformułowana w jego książce Prawo, legislacja i wolność. Jej podstawę stanowi teoria ładu spontanicznego, oparta na przeciwstawieniu dwóch rodzajów porządku: wyrosłego, powstałego w wyniku przestrzegania przez jego elementy pewnych ogólnych zasad, oraz organizacji, powstałej przez świadome i celowe uporządkowanie elementów struktury. Głównym twierdzeniem Hayek głosi, że nowoczesne społeczeństwo, jako należące do ładów spontanicznych, nie podlega ocenom ze względu na sprawiedliwość i niesprawiedliwość. Takie ujęcie przeciwstawia się pewnym głęboko zakorzenionym intuicjom moralnym, których Hayekowską analizę i odrzucenie rekonstruujemy w środkowej partii tekstu. Jego resztę poświęcamy na krótką charakterystykę “pozytywnego” ujęcia sprawiedliwości Hayeka w zestawieniu z podobną teorią R. Nozicka.
Determinizm i posybilizm geograficzny w geopolityce
Authors: Romer Eugeniusz
Published: November 2022

Geografia nie stanowi o wszystkim – słowa te, oczywiste dla współczesnych badaczy stosunków międzynarodowych, nie były takimi dla prekursorów i klasyków geopolityki przełomu XIX i XX wieku. Nadal zresztą nie są dla niektórych publicystów, zajmujących się tą dziedziną. W klasycznym okresie część badaczy uległa fascynacji odkryciem związków pomiędzy geografią a losami państw, społeczeństw i ludów do tego stopnia, że uważali je za jedyny czynnik mający istotny na nie wpływ. W niektórych przypadkach zaprowadziło ich to – jak Friedricha Ratzla – do konstruowania programów politycznych, które miały tragiczne i zbrodnicze konsekwencje. Nurt determinizmu geograficznego spotkał się z naukową polemiką, z której wyłonił się posybilizm geograficzny – pogląd, w myśl którego geografia stwarza człowiekowi pewne możliwości, w których on, działając podmiotowo, może wybierać. Celem tej pracy jest precyzyjne zdefiniowanie determinizmu i posybilizmu geograficznego oraz wskazanie ich elementów konstytutywnych. Odbędzie się to poprzez odwołanie do prac twórców klasycznej geopolityki i ich krytyków: Rudolfa Kjelléna, Frierdricha Ratzla, Paula Vidal de la Blache'a, Luciena Febvre'a oraz Halforda Johna Mackindera.
Happiness Management. A Social Well-being multiplier. Social Marketing and Organizational Communication.
Authors: Cuesta-Valiño Pedro
Published: November 2022

On behalf of the Happiness University Network, we are pleased to present here an extract of the information concerning the universities working to generate the diffusion of this network. Specifically, with the support of the University of Salamanca and the Pontifical University of Salamanca the aim is to create a friendly and working environment for the dissemination and discussion of the latest scientific and practical developments in the fields of happiness economics, corporate wellbeing, happiness management and organisational communication. It also offers an opportunity for productive encounters, the promotion of collaborative projects and the encouragement of international networking. Below you will find papers related to: Economics of happiness, happiness management, organisational communication, welfare state economics, consumer happiness, leadership, social marketing, happiness management and SDGs, happiness management in human resource strategies, learning and competencies in happiness management, learning and competencies in social well-being, measurement and indicators of happiness and well-being and history of welfare economics.
Przeklęte stulecie - cudowne stulecie: O kompensacyjnych aspektach dziewiętnastowiecznej literatury polskiej
Authors: Musiał Jan
Published: November 2022

A CURSED CENTURY – A WONDERFUL CENTURY From Zygmunt Krasiński, who was the first to notice that the poetry of his contemporaries was this kind of compensation of a historic tragedy of the nation, to other Romantics, who gave this sentiment a narrower literary expression in the form of messianism, variously understood, and further on, to positivist compensatory organic work, and to the Young Polish call for an act that would overcome spiritual incapacity – the author constructs his argument, illustrating it abundantly with examples of selected literary works. Indeed, he offers an “illustration” of the title thesis rather than providing the ultimate proof of it. Nevertheless the presented material appears sufficient to provoke substantive critique from the point of view of both literary criticism and sociology of literature, in the spirit of the current studies in the cultural history of literature and the entanglement of literary works of art in extra-literary contexts. This kind of critique also has a 19th century predecessor, Stanisław Brzozowski, whose views conclude the discussion. Therefore, this is inherently a historical literary study, but its main thesis is psychoanalytic in character. From this viewpoint, after elucidating the notion of compensation, which in literature appears as sublimation, the author follows a 19th-century trail, beginning with the artists’ passive reaction to humiliation brought about by captivity, and leading to the active “pursuit of power” when captivity was coming to an end. Mythologized in this way, reality, paradoxically, found support in the ideology of sarmatism, which had been overcome a century before and now came to be seen as a positive spiritual tradition.
Knowledge, Skills and Attitude of Pre-Service Mathematics Teachers Towards Higher-Order Thinking Skills
Authors: Ahmat Norhayati , Azmee Nor Afzalina , hamed Nurul Huda Mo , Zamzamir Zamzana , Zahari Nur Syuhada , Shafie Sabarina , Mohamed Nurul Akmal , Raja-Ma’amor-Shah Raja Noor Farah Azura
Published: November 2022

This research was aimed to determine the level of knowledge, skills and attitude of pre-service Mathematics teachers in Universiti Pendidikan Sultan Idris (UPSI) towards higher-order thinking skills (HOTS) and whether the elements of HOTS were translated into the teaching courses. The research was also designed to analyze the relationship between the pre-service Mathematics teachers’ exposure to HOTS through the teaching courses and their level of knowledge, skills and attitude towards HOTS. The study utilized a quantitative approach by administration of a survey to a simple random sample of 110 pre-service Mathematics teachers from UPSI. A questionnaire with five different parts was used as the research instrument with a reliability value of .979. The collected data were then analyzed using descriptive and inferential statistics. The descriptive statistics were used to determine the mean scores of the level of knowledge, skills and attitude among the pre-service Mathematics teachers, whereas inferential statistics using Pearson-r correlation was implemented to describe the relationship between the studied variables. The findings demonstrated that the knowledge and skills of pre-service Mathematics teachers towards HOTS were at a moderate level as opposed to their attitude and exposure to HOTS which were found to be at a high level. The data analysis using Pearson correlation illustrated a significant positive relationship with r = .727, r = .757 and r = .667 between the exposure to HOTS through the teaching courses and the level of knowledge, skills and attitude regarding HOTS of pre-service Mathematics teachers at UPSI, respectively. In conclusion, the research here indicates that pre-service Mathematics teachers in general, are positive towards the implementation of HOTS but they are lacking in terms of knowledge and skills. This research is useful in the field of Mathematics education as it can serve as a guidance to further enhance the knowledge, skills and attitudes especially for future Mathematics teachers in implementing HOTS effectively and improving the quality of the teaching program offered by the university indirectly.
Angus Macleod (1933–2021): in memoriam
Authors: Clark Christopher
Published: November 2022

On 29 April 2021, Professor Hugh Angus Macleod, Angus as he was known
to his family and friends, passed away at his home in Tucson, Arizona.
Angus was a leading authority in the field of thin film optics, and he
leaves behind a legacy of extraordinary contributions to the thin film
community. This article outlines Angus’s career in
optics—a career that spanned over 60 years. Not only was Angus
an eminent and distinguished scientist, he was also a
great teacher, mentor, colleague and friend to the entire thin film
optics world.
Application of photothermal therapy for the treatment of cutaneous melanoma, using an indocyanine green nanoemulsion
Authors: Martinelli L. P. , Jasinevicius G. , Moriyama L. T. , Buzzá H. , Chen J. , Zheng G. , Kurachi C.
Published: November 2022

Melanoma is the most aggressive type of skin cancer, with few effective treatments. Indocyanine green nanoemulsion for photothermal therapy was first time investigated and showed significant reduction of the pigmented tumors.
Photoacoustic and Photothermal: Progress to Date Towards Fostering Clinical Diagnosis
Authors: de Souza Monique , de Castro-Hoshino Lidiane Vizioli , Moratto Edilaine Martins , da Veiga Flavia Franco , Sato Francielle , Hernandes Luzmarina , Svidzinski Terezinha Inez Estivalet , Baesso Mauro Luciano
Published: November 2022

In this work, the application of photoacoustic and photothermal methods for the evaluation of physicochemical properties of biological systems will be presented as well as the state of art of these methods fostering clinical diagnostics.
Thermo-Optical Characterization of Natural Fluorescent Dyes for Potential of Hydrogen Indicators
Authors: Lourenço Larissa R. , de Lima Sthanley R. , Santos Tácio T. S. , Messias Djalmir N. , Andrade Acácio A. , Pilla Viviane
Published: November 2022

The natural dyes were extracted at different potential hydrogen (pH) values. The spectroscopy and fluorescence quantum yield were determined for annatto and anthocyanin. These solutions were evaluated as a possible pH indicator for adulterated milk.
Generalized Orbital Angular Momentum Symmetry in Parametric Amplification
Authors: Rodrigues R. B. , Alves G. B. , Barros R. F. , Souza C. E. R. , Khoury A. Z.
Published: November 2022

We investigate interesting symmetry properties verified by the down-converted beams produced in optical parametric amplification with structured light. We show the Poincaré sphere symmetry observed in the spatial modes of signal and idler fields.
Distinct behavior of paraxial wave equation solutions in a third-order nonlinear medium
Authors: Rocha J. C. A. , Pires D. G. , Motta M. R. L. , Litchinitser N. M. , Vianna S. S. , Fonseca E. J. S. , Ferraz J.
Published: November 2022

We theoretically predict the generation of nearly pure Hermite-Gauss modes as a result of the four-wave mixing of two Hermite-Gauss beams. Four-wave mixing with others paraxial wave equation solutions results in beams with multiple modes.
Unconditional Multicolor Teleportation
Authors: Konieczniak Igor , Faria Lucas Nunes , Derani Pedro Antonio J. , Meirelles Paula S. , de Araújo Renné L. C. Medeiros , Martinelli Marcelo
Published: November 2022

We demonstrate the first evidence of teleportation of a coherent state between distinct wavelengths of the field, using a protocol for unconditional teleportation in the continuous variable domain.
All-fiber Dynamically Tunable Beamsplitter for Quantum Random Number Generators
Authors: Argillander Joakim , Alarcón Alvaro , Xavier Guilherme B.
Published: November 2022

In this work we demonstrate an all-fiber dynamically tunable beamsplitter based on a Sagnac interferometer capable of realizing measurement-device independent protocols for certifying the privacy of the generated sequence.
Observation of Third-Harmonic Saturation in Helium due to Ionization Depletion
Authors: Zuffi Armando Valter Felicio , Junior Nilson Dias Vieira , Samad Ricardo Elgul
Published: November 2022

We report the saturation of the third harmonic generated in Helium by ultrashort laser pulses, and describe the observed plateau based on the depletion of the electrons generating the harmonics in a restricted interaction volume.
On the optical extinction coefficient of 2D materials: disorder, long-range and energy harvesting applications
Authors: Rico J. , Olaya D. , Canaval J. , Navarrete C. , Cardenas G. , Hernandez Y.
Published: November 2022

Dispersions of 2D materials were produced by liquid phase exfoliation. Spectral differences are attributed to an increased presence of functional groups, the optical extinction coefficient and band-gap. This methodology allows integration in actuator and piezoelectric devices.
Third-Order Nonlinear Optical Properties of Perovskite Quantum Dots
Authors: Sousa C. A. , Bonato L. G. , Gonçalves E. S. , Alo A. , Padilha L. A.
Published: November 2022

Size dependence of the third order nonlinear absorption and refraction is investigated in CsPbBr3 perovskite quantum dots indicating a similar volume dependence already observed for other nanomaterials.
Analysis of biofilm growth over bulk fill composite resins through optical coherence tomography
Authors: Lins Nathalia Alexandre Eloy , Lins Maria Carolina Oliveira , Henrique Renan Lennon Silva , De Souza Santos Palmeira Pettely Thaíse , de Vasconcelos Catão Maria Helena Chaves , de Lemos Campello Sérgio , Gomes Anderson Stevens Leônidas , do Nascimento Patrícia Lins Azevedo , de Oliveira Mota Cláudia Cristina Brainer
Published: November 2022

OCT evaluated the biofilm adhesion over dental enamel and bulk fill composite resins. Samples were exposed to Staphylococcus aureus and Candida albicans and scanned by OCT. Resins showed higher Candida colonization, compared to enamel group.
Characterizing surgical wound sites with spatial frequency domain imaging (SFDI)
Authors: Zhang Lai , Bounds Alistair D. , Fleming James P. , Girkin John M.
Published: November 2022

We report on the use of SFDI to monitor the health of surgical wounds to minimize infection. Results from Monte Carlo simulations, phantom and in vivo measurements indicate the potential for the method.
Use of fluorescence spectroscopy to determine adulteration in organic soybean oil
Authors: Lopes Carla Regina Borges , Silva Heron Dominguez Torres da , Courrol Lilia Coronato
Published: November 2022

Emission spectra and fluorescence lifetime of samples excited between λ340 and λ500 nm were combined to determine adulteration of organic soybean oil by the addition of aliquots of conventional soybean oil.
Laser Induced Fluorescence Spectroscopy of the Rb 5S - 6S One- and Two-Photon M1 Transition
Authors: Knize Randy J , McLaughlin Carson D , Lindsay Mark D
Published: November 2022

We measure the Rb 5S-6S M1 transition, in a cell or atomic beam. We find the two-photon hyperfine transitions, and splittings with accuracy 10 kHz. We report progress on the one-photon highly forbidden transition measurements.
Ultraviolet Protection of Sunglasses as a function of Eye Pupillary Diameter
Authors: Masili Mauro , Ventura Liliane
Published: November 2022

Ultraviolet protection is critical for sunglasses and dilation of the pupil plays important role. We estimate the pupil diameter and calculate the solar ultraviolet influx through the pupil of the human eye.
Ultra-long lifetime, persistent luminescence, and scintillation features of Pr3+ and Na+ doped yttrium tantalates
Authors: Labaki H. P. , Caixeta F. J. , Marques N. P. , Guidelli E. J. , Rodrigues L. C. V. , Gonçalves R. R.
Published: November 2022

In this work, we report the synthesis, structural, morphological, and spectroscopic characterization of Pr3+ and Na+-doped yttrium tantalates. An ultra-long lifetime, persistent luminescence and scintillation were observed making these materials potential candidates for nanomedicine applications.
Luminescent oxide nanocrystals for the development of thermal bioprobes
Authors: Barbosa Italia Vallerini , Dantelle Geraldine , Ibanez Alain , Maia Lauro June Queiroz
Published: November 2022

This work aims to investigate how the thermal sensitivity of different oxide materials can be enhanced by the host matrix when codoped with Nd3+ and Yb3+ ions, in order to develop thermal probes for biomedical purposes.
Phase-based plasmonic biosensor for SARS-COV-2 virus detection
Authors: Cuanalo-Fernández J.P. , Korneev N. , Cosme-Bolaños I. , De-la-Mora-Mojica M.B. , Spezzia-Mazzoco T. , Guerra-Hernández S.F. , Díaz-Failach C.I , Ramirez-Cordero A. , Ramos-García R. , Mansurova S.
Published: November 2022

The detection scheme based on phase detection of SPR response was developed. We show that the proposed biosensing scheme can detect SARS-CoV-2 genetic material with high specificity, low detection limit and short detection time.