bluuebunny/crossref_metadata_2025 huggingface dataset:
Chemical Modulators for Targeting Autism Spectrum Disorders: From Bench to Clinic
Authors: Lim Songhyun , Lee Sanghee
Published: August 2022

Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by diverse behavioral symptoms such as repetitive behaviors, social deficits, anxiety, hyperactivity, and irritability. Despite their increasing incidence, the specific pathological mechanisms of ASD are still unknown, and the degree and types of symptoms that vary from patient to patient make it difficult to develop drugs that target the core symptoms of ASD. Although various atypical antipsychotics and antidepressants have been applied to regulate ASD symptoms, these drugs can only alleviate the symptoms and do not target the major causes. Therefore, development of novel drugs targeting factors directly related to the onset of ASD is required. Among the various factors related to the onset of ASD, several chemical modulators to treat ASD, focused on serotonin (5-hydroxytryptamine, 5-HT) and glutamate receptors, microbial metabolites, and inflammatory cytokines, are explored in this study. In particular, we focus on the chemical drugs that have improved various aspects of ASD symptoms in animal models and in clinical trials for various ages of patients with ASD.
Assessment of Cosmetic Properties and Safety of Use of Model Washing Gels with Reishi, Maitake and Lion’s Mane Extracts
Authors: Ziemlewska Aleksandra , Wójciak Magdalena , Mroziak-Lal Kamila , Zagórska-Dziok Martyna , Bujak Tomasz , Nizioł-Łukaszewska Zofia , Szczepanek Dariusz , Sowa Ireneusz
Published: August 2022

Natural cosmetics are becoming more and more popular every day. For this reason, this work investigates the properties of mushroom extracts, which are not as widely used in the cosmetics industry as plant ingredients. Water extracts of Grifolafrondosa (Maitake), Hericiumerinaceus (Lion’s Mane) and Ganoderma lucidum (Reishi) were tested for their antioxidant properties, bioactive substances content, skin cell toxicity, ability to limit TEWL, effect on skin hydration and pH, and skin irritation. Our research showed that Maitake extract contained the highest amount of flavonoids and phenols, and also showed the most effective scavenging of DPPH and ABTS radicals as well as Chelation of Fe2+ and FRAP radicals, which were 39.84% and 82.12% in a concentration of 1000 µg/mL, respectively. All tested extracts did not increase the amount of ROS in fibroblasts and keratinocytes. The addition of mushroom extracts to washing gels reduced the irritating effect on skin, and reduced the intracellular production of free radicals, compared with the cosmetic base. Moreover, it was shown that the analyzedcosmetics had a positive effect on the pH and hydration of the skin, and reduced TEWL.
Tetrahydrocurcumin-Related Vascular Protection: An Overview of the Findings from Animal Disease Models
Authors: Zhang Li , Li Changhu , Wang Sicheng , Avtanski Dimiter , Hadzi-Petrushev Nikola , Mitrokhin Vadim , Mladenov Mitko , Wang Feng
Published: August 2022

Tetrahydrocurcumin (THC), one of the major metabolites of CUR, possesses several CUR-like pharmacological effects; however, its mechanisms of action are largely unknown. This manuscript aims to summarize the literature on the preventive role of THC on vascular dysfunction and the development of hypertension by exploring the effects of THC on hemodynamic status, aortic elasticity, and oxidative stress in vasculature in different animal models. We review the protective effects of THC against hypertension induced by heavy metals (cadmium and iron), as well as its impact on arterial stiffness and vascular remodeling. The effects of THC on angiogenesis in CaSki xenografted mice and the expression of vascular endothelial growth factor (VEGF) are well documented. On the other hand, as an anti-inflammatory and antioxidant compound, THC is involved in enhancing homocysteine-induced mitochondrial remodeling in brain endothelial cells. The experimental evidence regarding the mechanism of mitochondrial dysfunction during cerebral ischemic/reperfusion injury and the therapeutic potential of THC to alleviate mitochondrial cerebral dysmorphic dysfunction patterns is also scrutinized and explored. Overall, the studies on different animal models of disease suggest that THC can be used as a dietary supplement to protect against cardiovascular changes caused by various factors (such as heavy metal overload, oxidative stress, and carcinogenesis). Additionally, the reviewed literature data seem to confirm THC’s potential to improve mitochondrial dysfunction in cerebral vasculature during ischemic stroke through epigenetic mechanisms. We suggest that further preclinical studies should be implemented to demonstrate THC’s vascular-protective, antiangiogenic, and anti-tumorigenic effects in humans. Applying the methods used in the presently reviewed studies would be useful and will help define the doses and methods of THC administration in various disease settings.
Furan-Containing Chiral Spiro-Fused Polycyclic Aromatic Compounds: Synthesis and Photophysical Properties
Authors: Nakano Koji , Takase Ko , Noguchi Keiichi
Published: August 2022

Spiro-fused polycyclic aromatic compounds (PACs) have received growing interest as rigid chiral scaffolds. However, furan-containing spiro-fused PACs have been quite limited. Here, we design spiro[indeno[1,2-b][1]benzofuran-10,10′-indeno[1,2-b][1]benzothiophene] as a new family of spiro-fused PACs that contains a furan unit. The compound was successfully synthesized in enantiopure form and also transformed to its S,S-dioxide derivative and the pyrrole-containing analog via aromatic metamorphosis. The absorption and emission properties of the obtained furan-containing chiral spiro-fused PACs are apparently different from those of their thiophene analogs that have been reported, owing to the increased electron-richness of furan compared to thiophene. All of the furan-containing chiral spiro-fused PACs were found to be circularly polarized luminescent materials.
Z-Guggulsterone Is a Potential Lead Molecule of Dawa-ul-Kurkum against Hepatocellular Carcinoma
Authors: Gupta Meenakshi , Ghufran Shaikh Maryam , Kausar Tasneem , Ali Rafat , Biswas Subhrajit , Nayeem Shahid M. , Ishrat Romana , Ali Sher , Ahmad Ajaz , Rather Irfan A. , Sarwat Maryam
Published: August 2022

An ancient saffron-based polyherbal formulation, Dawa-ul-Kurkum (DuK), has been used to treat liver ailments and other diseases and was recently evaluated for its anticancer potential against hepatocellular carcinoma (HCC) by our research team. To gain further insight into the lead molecule of DuK, we selected ten active constituents belonging to its seven herbal constituents (crocin, crocetin, safranal, jatamansone, isovaleric acid, cinnamaldehyde, coumaric acid, citral, guggulsterone and dehydrocostus lactone). We docked them with 32 prominent proteins that play important roles in the development, progression and suppression of HCC and those involved in endoplasmic reticulum (ER) stress to identify the binding interactions between them. Three reference drugs for HCC (sorafenib, regorafenib, and nivolumab) were also examined for comparison. The in silico studies revealed that, out of the ten compounds, three of them—viz., Z-guggulsterone, dehydrocostus lactone and crocin—showed good binding efficiency with the HCC and ER stress proteins. Comparison of binding affinity with standard drugs was followed by preliminary in vitro screening of these selected compounds in human liver cancer cell lines. The results provided the basis for selecting Z-guggulsterone as the best-acting phytoconstituent amongst the 10 studied. Further validation of the binding efficiency of Z-guggulsterone was undertaking using molecular dynamics (MD) simulation studies. The effects of Z-guggulsterone on clone formation and cell cycle progression were also assessed. The anti-oxidant potential of Z-guggulsterone was analyzed through DPPH and FRAP assays. qRTPCR was utilized to check the results at the in vitro level. These results indicate that Z-guggulsterone should be considered as the main constituent of DuK instead of the crocin in saffron, as previously hypothesized.
A Plausible Mechanism for the Iridium-Catalyzed Hydrogenation of a Bulky N-Aryl Imine in the (S)-Metolachlor Process
Authors: Kwan Amanda L. , Morris Robert H.
Published: August 2022

The hydrogenation of N-(2-ethyl-6-methylphenyl)-1-methoxypropan-2-imine is the largest-scale asymmetric catalytic process for the industrial production of agrochemical (S)-metolachlor. The challenging hydrogenation across the sterically crowded carbon–nitrogen double bond was achieved using a mixture of [IrCl(COD)]2, (R,SFc)-Xyliphos, NBu4I and acetic acid. Acetic acid was critical in achieving excellent productivity and activity. Despite its industrial significance, a mechanism that explains how the sterically hindered bond in the imine is reduced has yet to be proposed. We propose a plausible proton-first, outer-sphere mechanism based on density functional theory calculations that is consistent with the experimentally observed activity and the enantioselectivity of the industrial process. Key findings include transition states involving acetate-assisted dihydrogen splitting, and a hydride transfer from a five-coordinate iridium trihydride directed by a C-H∙∙∙Ir interaction. This article was submitted to a Special Issue in honor of Professor Henri Kagan.
Impact of Nanolayered Material and Nanohybrid Modifications on Their Potential Antibacterial Activity
Authors: Alali Hasna Abdullah , Saber Osama , Berekaa Mahmoud Mohamed , Osama Doaa , Ezzeldin Mohamed Farouk , Shaalan Nagih M. , AlMulla Abdulaziz Abdulrahman
Published: August 2022

Due to an escalating increase in multiple antibiotic resistance among bacteria, novel nanomaterials with antimicrobial properties are being developed to prevent infectious diseases caused by bacteria that are common in wastewater and the environment. A series of nanolayered structures and nanohybrids were prepared and modified by several methods including an ultrasonic technique, intercalation reactions of fatty acids, and carbon nanotubes, in addition to creating new phases based on zinc and aluminum. The nanomaterials prepared were used against a group of microorganisms, including E. coli, S. aureus, Klebsiella pneumoniae and Pseudomonas aeruginosa. Experimental results revealed that a nanohybrid based on carbon nanotubes and fatty acids showed significant antimicrobial activity against E. coli, and can be implemented in wastewater treatment. Similar behavior was observed for a nanolayered structure which was prepared using ultrasonic waves. For the other microorganisms, a nanolayered structure combined with carbon nanotubes showed a significant and clear inhibitory effect on S. aureus, Klebsiella pneumoniae and Pseudomonas aeruginosa. It is concluded that the nanolayered structures and nanohybrids, which can be modified at low cost with high productivity, using simple operations and straightforward to use equipment, can be considered good candidates for preventing infectious disease and inhibiting the spread of bacteria, especially those that are commonly found in wastewater and the environment.
Determinants, Screening, Prevention and Management of Obesity in Youth: New Evidence and Horizons
Authors: Androutsos Odysseas , Charmandari Evangelia
Published: August 2022

The prevalence of obesity has significantly increased over the last four decades worldwide [...]
Phytochemical Composition and Cytoprotective Properties of the Endemic Sideritis sipylea Boiss Greek Species: A Valorization Study
Authors: Di Giacomo Silvia , Di Sotto Antonella , Angelis Apostolis , Percaccio Ester , Vitalone Annabella , Gullì Marco , Macone Alberto , Axiotis Evangelos , Skaltsounis Alexios Leandros
Published: August 2022

Sideritis sipylea Boiss. (Fam. Lamiaceae) is an endemic plant of the North Aegean Islands (Greece), commonly known as ironwort. Traditionally, its aerial parts have been used to relieve several ailments, especially gastrointestinal disorders, however, with scant knowledge about the pharmacological basis. In the present study, an endemic S. sipylea Greek species from Lesvos Island has been characterized for phytochemical composition and biological activities, in order to give a possible scientific basis to its traditional use and to highlight a further nutraceutical interest as a source of bioactive phytochemicals and extracts. Three different fractions obtained from a methanolic extract of S. sipylea aerial parts by using ethyl acetate with 10 (S10), 20 (S20), and 50% (S50) methanol as fractionation solvents were phytochemically characterized. Moreover, their antioxidant power and cytoprotective activity in different human cell lines were evaluated. The phytochemical analysis highlighted the presence of flavonoids, iridoids, and phenolic acids in all the tested samples. Particularly, the S10 fraction mainly contained iridoids, while S20 and S50 lavandulifolioside and chlorogenic acid, respectively. The fractions also showed antioxidant properties, S10 and S20 being the most potent. When assessed in human cholangiocytes, they counteracted the cytotoxicity of the tBOOH pro-oxidant agent, by reducing ROS levels and affecting GSH antioxidant system. The present findings highlight a possible interest in S10 and S20 fractions from S. sipylea as sources of bioactive molecules and stimulate further studies in order to characterize their possible application for nutraceutical and pharmaceutical purposes.
Toxicity Profiles of Kleeb Bua Daeng Formula, a Traditional Thai Medicine, and Its Protective Effects on Memory Impairment in Animals
Authors: Waiwut Pornthip , Kengkoom Kanchana , Pannangrong Wanassanun , Musigavong Natdanai , Chheng Chantha , Plekratoke Kusawadee , Taklomthong Pitchayakarn , Nillert Nutchareeporn , Pitiporn Supaporn , Kwankhao Pakakrong , Daodee Supawadee , Chulikhit Yaowared , Montakantirat Orawan , Boonyarat Chantana
Published: August 2022

Kleeb Bua Daeng (KBD) formula has long been used in Thailand as a traditional herbal medicine for promoting brain health. Our recent reports illustrated that KBD demonstrates multiple modes of action against several targets in the pathological cascade of Alzheimer’s disease (AD). The main purpose of the present study was to determine the protective effect and mechanism of KBD in amyloid beta (Aβ)-induced AD rats and its toxicity profiles. Pretreatment with the KBD formula for 14 days significantly improved the short- and long-term memory performance of Aβ-induced AD rats as assessed by the Morris Water Maze (MWM) and object-recognition tests. KBD treatment increased the activities of the antioxidant enzymes catalase, superoxide dismutase, and glutathione peroxidase; reduced the malondialdehyde content, and; decreased the acetylcholinesterase activity in the rat brain. An acute toxicity test revealed that the maximum dose of 2000 mg/kg did not cause any mortality or symptoms of toxicity. An oral, subchronic toxicity assessment of KBD at doses of 125, 250, and 500 mg/kg body weight/day for 90 days showed no adverse effects on behavior, mortality, hematology, or serum biochemistry. Our investigations indicate that KBD is a nontoxic traditional medicine with good potential for the prevention and treatment of AD.
MoS2-Cu/CuO@graphene Heterogeneous Photocatalysis for Enhanced Photocatalytic Degradation of MB from Water
Authors: Jilani Asim , Melaibari Ammar A.
Published: August 2022

The industrial revolution resulted in the contamination of natural water resources. Therefore, it is necessary to save and recover the natural water resources. In this regard, polymer-based composites have attracted the scientific community for their application in wastewater treatment. Herein, molybdenum disulfide composites with a mix phase of copper, copper oxide and graphene (MoS2-Cu/CuO@GN) were synthesized through the hydrothermal method. Methylene blue (MB) was degraded by around 93.8% within the 30 min in the presence of MoS2-Cu/CuO@GN under visible light. The degradation efficiency was further enhanced to 98.5% with the addition of H2O2 as a catalyst. The photocatalytic degradation efficiency of pure MoS2, MoS2-Cu/CuO and MoS2-Cu/CuO@GN were also investigated under the same experimental conditions. The structural analysis endorses the presence of the Cu/CuO dual phase in MoS2. The charge recombination ratio and band gap of MoS2-Cu/CuO@GN were also investigated in comparison to pure MoS2 and MoS2-Cu/CuO. The chemical states, the analysis of C1s, O1s, Mo3d and Cu2p3, were also analyzed to explore the possible interaction among the present elements. The surface morphology confirms the existence of Cu/CuO and GN to MoS2.
Study on the Physical, Thermal and Mechanical Properties of SEBS/PP (Styrene-Ethylene-Butylene-Styrene/Polypropylene) Blend as a Medical Fluid Bag
Authors: Murthe Satisvar Sundera , Sreekantan Srimala , Mydin Rabiatul Basria S. M. N.
Published: August 2022

The presence of DEHP in PVC-based medical bags poses a significant health risk to patients undergoing blood transfusion. In order to fabricate safer medical fluid bag materials, the use of SEBS/PP polymer blend as a potential material was investigated. Polymeric blends with varying weight percentages of styrene-ethylene-butylene-styrene/polypropylene (SEBS/PP) were fabricated by melt mixing using an internal Haake mixer. The physical properties of the SEBS/PP polymer blends were investigated using differential scanning calorimetry (DSC), X-ray diffraction (XRD), and inductively coupled plasma–mass spectrometry (ICP-MS). In addition, measurements of the mechanical strength (tensile strength and Young’s modulus) as per ASTM 638, polymer hardness was tested using a durometer and swelling was analysed through water absorption and compared with commercial PVC-based blood bags. The results indicate that the SEBS/PP 50/50 blend has approximately similar characteristics as PVC-based blood bags. The SEBS/PP polymer blend possesses approximate tensile strength and Young’s modulus with values of 23.28 MPa and 14.42 MPa, respectively, to that of the conventional PVC blood bags. The results show that the SEBS/PP polymer blends have negligible zinc and aluminium migration with values of 1.6 and 2.1 mg/kg, respectively, and do not elute any harmful leachates, while the thermal studies indicate that the studied SEBS/PP materials are capable of withstanding steam sterilisation at 120 °C and cold storage below −40 °C. The investigated material can be utilized for medical fluid bags and contributes towards sustainable development goals, such as SDG 3 to ensure healthy lives and promote well-being, as well as SDG 12 to ensure sustainable consumption and production patterns.
Research Progress on Emerging Polysaccharide Materials Applied in Tissue Engineering
Authors: Su Chunyu , Chen Yutong , Tian Shujing , Lu Chunxiu , Lv Qizhuang
Published: August 2022

The development and application of polysaccharide materials are popular areas of research. Emerging polysaccharide materials have been widely used in tissue engineering fields such as in skin trauma, bone defects, cartilage repair and arthritis due to their stability, good biocompatibility and reproducibility. This paper reviewed the recent progress of the application of polysaccharide materials in tissue engineering. Firstly, we introduced polysaccharide materials and their derivatives and summarized the physicochemical properties of polysaccharide materials and their application in tissue engineering after modification. Secondly, we introduced the processing methods of polysaccharide materials, including the processing of polysaccharides into amorphous hydrogels, microspheres and membranes. Then, we summarized the application of polysaccharide materials in tissue engineering. Finally, some views on the research and application of polysaccharide materials are presented. The purpose of this review was to summarize the current research progress on polysaccharide materials with special attention paid to the application of polysaccharide materials in tissue engineering.
Femininity, Motherhood, and Feminism: Reflections on Paul Mendes-Flohr’s Biography Martin Buber: A Life of Faith and Dissent
Authors: Hadad Yemima
Published: August 2022

In his intellectual biography of the Jewish philosopher Martin Buber, A Life of Faith and Dissent written in 2019, Paul Mendes-Flohr offers us an intimate view of Buber’s life and thought without neglecting the story of the women in his life and their contributions to shaping his thought. In this short reflection essay, I wish to present a crosscutting perspective on the important biography written by Paul Mendes-Flohr, by highlighting Buber’s relation to women, feminism, and femininity, a perspective that emerges in almost every chapter of the biography. This angle, I hope, will illuminate not only the personal–psychological dimension of Buber’s inner life but also the deep currents of his intellectual life and thought.
Urban Tree Classification Based on Object-Oriented Approach and Random Forest Algorithm Using Unmanned Aerial Vehicle (UAV) Multispectral Imagery
Authors: Guo Qian , Zhang Jian , Guo Shijie , Ye Zhangxi , Deng Hui , Hou Xiaolong , Zhang Houxi
Published: August 2022

Timely and accurate information on the spatial distribution of urban trees is critical for sustainable urban development, management and planning. Compared with satellite-based remote sensing, Unmanned Aerial Vehicle (UAV) remote sensing has a higher spatial and temporal resolution, which provides a new method for the accurate identification of urban trees. In this study, we aim to establish an efficient and practical method for urban tree identification by combining an object-oriented approach and a random forest algorithm using UAV multispectral images. Firstly, the image was segmented by a multi-scale segmentation algorithm based on the scale determined by the Estimation of Scale Parameter 2 (ESP2) tool and visual discrimination. Secondly, spectral features, index features, texture features and geometric features were combined to form schemes S1–S8, and S9, consisting of features selected by the recursive feature elimination (RFE) method. Finally, the classification of urban trees was performed based on the nine schemes using the random forest (RF), support vector machine (SVM) and k-nearest neighbor (KNN) classifiers, respectively. The results show that the RF classifier performs better than SVM and KNN, and the RF achieves the highest accuracy in S9, with an overall accuracy (OA) of 91.89% and a Kappa coefficient (Kappa) of 0.91. This study reveals that geometric features have a negative impact on classification, and the other three types have a positive impact. The feature importance ranking map shows that spectral features are the most important type of features, followed by index features, texture features and geometric features. Most tree species have a high classification accuracy, but the accuracy of Camphor and Cinnamomum Japonicum is much lower than that of other tree species, suggesting that the features selected in this study cannot accurately distinguish these two tree species, so it is necessary to add features such as height in the future to improve the accuracy. This study illustrates that the combination of an object-oriented approach and the RF classifier based on UAV multispectral images provides an efficient and powerful method for urban tree classification.
Adherence to treatment of patients with chronic heart failure of ischemic etiology
Authors:   Turkmen State Medical University named after M. Garryev, Hospital with the Scientific and Clinical Center for Cardiology, Ashgabat, Chapau A. Kh. , Odzharova B. G. ,   Turkmen State Medical University named after M. Garryev, Hospital with the Scientific and Clinical Center for Cardiology, Ashgabat, Gurbanaliev S. A. ,   Turkmen State Medical University named after M. Garryev, Hospital with the Scientific and Clinical Center for Cardiology, Ashgabat, Shikhmyradova G. A. ,   Turkmen State Medical University named after M. Garryev, Hospital with the Scientific and Clinical Center for Cardiology, Ashgabat, Myatzhanova D. Kh. ,   Turkmen State Medical University named after M. Garryev, Hospital with the Scientific and Clinical Center for Cardiology, Ashgabat
Published: August 2022

The purpose of the study: to research adherence to therapy in patients with chronic heart failure of ischemic etiology. Materials and methods. The examination was carried out in the Department of Myocardial Infarction, Hospital with the Scientific and Clinical Center for Cardiology.
Study of the efficacy of comprehensive rehabilitation of fine motor skills in patients after ischemic stroke, using hardware technology with biofeedback
Authors:   Medsi Group, Clinical Hospital No. 1, Moscow, Russia, Sidyakina I. V. ,   Medical and Biological University of Innovation and Continuing Education of the Federal Medical Biophysical Center named after A. I. Burnazyan, Lupanova K. V. ,   Medical and Biological University of Innovation and Continuing Education of the Federal Medical Biophysical Center named after A. I. Burnazyan, Korchazhkina N. B. ,   FSBSI Petrovsky National Research Centre of Surgery, Moscow; FSBEI HE A. I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of Russia, Moscow, Mikhailova A. A. ,   FSBSI Petrovsky National Research Centre of Surgery, Moscow; FSBEI HE A. I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of Russia, Moscow, Shapovalenko T. V. ,   Medsi Group, Clinical Hospital No. 1, Moscow, Russia, Koneva E. S. ,   Medsi Group, Clinical Hospital No. 1, Moscow, Russia;  Sechenov First Moscow State Medical University (Sechenov University), Moscow
Published: August 2022

The article presents the current data on the importance of applying a multimodal approach including hardware techniques with biofeedback in restoring fine motor skills of the hand in patients after ischemic stroke in the early recovery period. The results of the combined use of peripheral magnetic stimulation (Magstim Rapid) with active training on the Hand Tutor device with biofeedback are described on the example of a clinical case. The efficiency of the complex approach was evaluated according to basic scales of neurological deficit: the National Institutes of Health Stroke Scale (NIHSS), the modified Rankin Scale, the Barthel Index for Activities of Daily Living, the Rivermead Activities of Daily Living Scale, the Montreal Cognitive Assessment Scale (MoCA). We also performed a quantitative assessment of motor deficits in the affected limb before and after application of the technique, using the MediTutor software. Based on the results of the study, a decrease in both neurological and motor deficits in the affected limb was revealed; however, further study of the effectiveness of the method with the selection of parameters and duration of therapy is necessary.
The efficiency of the TensorFlow models in the application to the task of detection of eyes in the photo
Authors: Burdukowsky S. O.
Published: August 2022

In this article, the author compares the effectiveness of TensorFlow detection models in solving the problem of detecting areas with eyes in human face photo. Experiments of two types were carried out: additional training of a pretrained detection model and training of the model from scratch. Face images from Flickr-Faces-HQ Dataset were used to form training and evaluation samples. The article describes the training parameters, shows classification and localization loss graphs, assesses the accuracy of the trained models, and also demonstrates the operation of the “SSD MobileNet V2 FPNLite 320×320” detection model trained from scratch, which received the highest accuracy scores after additional training and training from scratch. For programs with a requirement for IoU of detected objects greater than 0.5, the accuracy of the model is 99.9 %. The results of the experiments can be applied in various researches, that use the TensorFlow platform to detect objects in images, and only one class of objects is detected.
Entrelaçando design e ficção científica
Authors: Luersen Eduardo Harry
Published: August 2022

O artigo discute como o chamado design especulativo pode ser vinculado à extrapolação tecnocientífica, uma importante característica do gênero da ficção científica, para cotejar e prototipar cenários potenciais e modelos imaginados, porém viáveis, de futuro. O trabalho sublinha importantes nuances entre diferentes abordagens ao design especulativo, considerando a especificidade de seus pressupostos epistemológicos. A discussão é entremeada por um estudo de caso: Daleko (2020), um projeto desenvolvido no programa Terraforming, do Strelka Institute. Este projeto consiste em um conjunto de nove fábulas de ficção científica aproximando os temas da gestão de resíduos, infraestrutura tecnológica e governança ambiental. Os contos discutem a concepção problemática do lixo como uma forma de exterioridade, ao mesmo tempo em que imaginam possíveis alternativas futuras para a gestão de resíduos a partir de uma perspectiva tecnopolítica mais abrangente. Após analisar a abordagem de Daleko, o artigo discute as implicações do design especulativo em contextos educacionais, como um modo de estimular designers em formação e pesquisadores oriundos de outras disciplinas a questionar como as práticas de suas áreas podem ser relacionadas ao impacto antropogênico no ambiente, de modo mais abrangente, e qual o seu papel no planejamento de infraestruturas tecnológicas mais viáveis para o ambiente natural e a biodiversidade atual.
Women's views on postnatal care from a midwife who has not provided their pregnancy and birth care: Implications for midwifery relationships
Authors:   , Horncastle Sally
Published: August 2022

In Aotearoa New Zealand (from hereafter New Zealand), postnatal care is typically provided in hospital and at home by a known Lead Maternity Carer (LMC) midwife who has provided continuity of care and lead maternity care throughout the childbearing episode. While this model of maternity care is accepted as optimal, increasingly and for a myriad of reasons, postnatal care is being provided by a midwife or midwives previously unknown to the woman and her family. This study aimed to explore women’s experience of postnatal care when provided in this context, in order to understand the critical components for establishing a constructive and supportive postnatal care experience. The study design was qualitative descriptive to enable a rich and data-close explication of the women’s experiences. Semi-structured interviews with eleven first-time mothers were analysed thematically to develop three main themes that captured the essence of their experiences. The findings confirmed that postnatal midwifery care is a highly valued and vital component of postnatal adjustment as a new parent. While continuity of care was desired by most women, they articulated a range of ways that midwives can build meaningful relationships when they meet women for the first time postnatally. Themes centred around how women navigated the postnatal period which was characterised as being challenging and how the midwife provided an anchoring presence as these new mothers grew in confidence as new mothers and when caring for their babies. Sub-themes identified why the study participants were cared for postnatally by midwives who were previously unknown to them, examined their postnatal experiences in hospital prior to going home and describes their first meetings with their postnatal midwives and the key ingredients which enabled their alliances to work constructively.
Estudo de caso sobre o uso racional de energia elétrica na prefeitura municipal de Toledo-PR / Case study on the rational use of electricity in the city hall of Toledo-PR
Authors: Salussoglia Ana Isabela Pianowski , Cavalli Bruno Roberto , Carvalho Kátia Cristina , Endler Kellen Dayelle , Ferrari Tatiane Caroline , Moreira Marcos Flávio Pinto
Published: August 2022

Saber consumir conscientemente os recursos disponíveis é um dos grandes desafios da sociedade moderna. Dentro desta linha, a prefeitura do município de Toledo-PR em 2012 buscou entender melhor o seu consumo de energia elétrica para uma administração cada vez mais eficaz deste recurso. Auxiliada pela Universidade Estadual do Oeste do Paraná, através da equipe de trabalho coordenada pelo Prof. Dr. Marcos Flávio Pinto Moreira, verificou-se que várias ações poderiam ser realizadas a fim de se utilizar a energia elétrica de forma mais racional. Uma das ações foi a campanha educativa para o uso racional de energia elétrica realizada no ano de 2012 e que gerou uma redução de 7,6% no consumo de energia no paço municipal. Foram realizadas conversas de conscientização com os funcionários, elaboração de material educativo e divulgação pela internet e pela TV. Outra ação realizada foi a determinação da melhor tarifa a ser contrata pela prefeitura junto à concessionária de energia. Verificou-se a partir de simulações que a tarifa horossazonal verde poderia levar a uma redução de 30% nos custos com energia no paço municipal. O diagnóstico resultante do desenvolvimento deste trabalho foi apresentado à administração do município.
Agravos à saúde mental dos profissionais de enfermagem em tempos de pandemia: revisão da literatura
Authors: Gonçalves Adelina Ferreira , Righetti Eline Aparecida Vendas , Magrin Sabrina Ferreira Furtado
Published: August 2022

Introdução: A pandemia causada pela COVID-19 colapsou o sistema de saúde e impactou na saúde física e mental dos profissionais de saúde. Objetivo: Analisar alguns estudos recentemente publicados sobre a pandemia de COVID-19 e seu possível impacto na saúde mental dos profissionais de saúde que enfrentam essa emergência sanitária. Método: Foi realizada uma revisão da literatura estruturada, permeada por um estudo teórico-reflexivo, em textos publicados nas bases de dados: SciELO, PubMed, Google Scholar. Os descritores em ciências da saúde utilizados foram: "Mental health", “Healthcare workers“, “Saúde Mental”, "COVID-19", “Profissionais de Enfermagem” e "Coronavirus", nos idiomas inglês e português. Dos 80 artigos encontrados foi feita uma seleção criteriosa, selecionando-se, a princípio, 44 textos e desses foram eliminados, primeiramente 20 e, na sequência, 10, depois 04, permanecendo 10 artigos para análise. Resultados: Após a análise dos artigos selecionados foi possível entender que os governos precisam tomar medidas enérgicas visando proteger a saúde de equipe de enfermagem e os sistemas de saúde. Programas de promoção do cuidado em saúde necessitam ser implementados e fortalecidos, assim como o prognóstico e o monitoramento dos agravos na saúde mental e física da enfermagem precisam ser efetivados. Conclusão: O estudo vem alertar o sistema de saúde para que fique mais atento aos sinais e sintomas de agravos à saúde mental dos profissionais de enfermagem em contato direto com os pacientes infectados pela COVID-19.
Análise das potenciais fontes de custeio da saúde do militar estadual no sistema de proteção social dos militares dos estados, do Distrito Federal e dos territórios
Authors: Felipack Dalva Rosane
Published: August 2022

O presente estudo tem por escopo fazer uma digressão histórica sobre a gênese dos instrumentos normativos que regem a proteção do militar estadual, especificamente quanto ao direito à saúde. Tal pesquisa transita pelos primórdios da inserção no diploma constitucional, estadual e leis específicas de modo a possibilitar uma visão ampla do sistema de saúde federal, estadual e complementar. O estudo evolucionário das leis propicia a análise sobre as possíveis fontes de custeio de saúde à luz do Sistema de Proteção Social dos Militares. Traz à reflexão esse relevante tema de forma a subsidiar propostas da Polícia Militar do Paraná - PMPR acerca da instituição de contribuição à saúde do policial militar decorrente de fonte de custeio prevista no Sistema de Proteção Social dos Militares a ser regulamentado no âmbito estadual.
Relato de caso - Orquiectomia em Ouriço-cacheiro (Coendou spinosus)
Authors: Silva Igor Roland Mathias Netto da , Silva Helena Oliveira , Ohyama Beatriz Miwa , Bernardi Amanda , Morel Ana Paula , Vasconcellos Daniel
Published: August 2022

Animais silvestres mantidos sob cuidados humanos podem não estar aptos à soltura, mesmo após intensa união de esforços de uma equipe multidisciplinar composta por Biólogos, Tratadores e Veterinários. O presente relato tem por objetivo apresentar procedimento de orquiectomia em Ouriço-cacheiro (Coendou spinosus), macho, adulto, mantido no Zoológico Municipal de Canoas, na região Sul do Brasil. O procedimento foi realizado devido ao fato de o corpo técnico da instituição não ter interesse na reprodução da espécie, além de estar classificado como em estado de “preocupação mínima” pela IUCN (International Union for Conservation of Nature) em sua lista vermelha de espécies ameaçadas. Após sedação e anestesia geral, o paciente foi submetido ao procedimento por meio da técnica modificada fechada, ao qual foi atribuído êxito, com boa recuperação do animal no pós-cirúrgico.
Proposta de modelo de software para apoio às atividades de prática profissional dos alunos do ensino médio
Authors: Desidério Vanessa , Frutuoso Hortevan Marrocos
Published: August 2022

A pandemia COVID-19 forçou algumas mudanças como o teletrabalho e ensino remoto. O ensino remoto seja síncrono ou assíncrono assim como o teletrabalho se tornam cada vez mais presentes. Na academia as fábricas de software já existiam antes da pandemia como estratégia para a prática profissional dos alunos, mas a literatura carece de mais estratégias sobre formas de mensurar o aprendizado do aluno nesse tipo de prática profissional.  Pensando nisso e analisando a experiência de outros colegas, criou-se uma proposta de modelo de gerenciamento de equipes de trabalho que desenvolvem softwares em instituições de ensino. O artigo teve como objetivo apresentar os principais requisitos para o protótipo, para tanto utilizou-se a pesquisa bibliográfica e análise qualitativa de outras experiências similares para construção do protótipo. Ainda sobre a perceptiva metodológica, trata-se de uma forma narrativa de relato de experiência.  O presente relato descreve a experiência de construção do protótipo, cujos resultados e diagramas apontam para a efetividade. Infelizmente não houve tempo hábil para versões de teste em ambiente real, mas através desse trabalho foi possível criar as orientações e diagramas principais. Espera-se com o compartilhamento da experiência a troca de saberes e o avanço nesse segmento.
A farmacopsiquiatria dos antidepressivos
Authors: Murta Marina Gabriela Magalhães Barbosa , Luz Kaiza Vilarinho da , Silva Rodrigo Rufino Pereira , Camilo Bruna Guimarães , Assis José Joceilson Cruz de , Manoel Marielle Boaventura de Sousa , Oliveira Rafael Carvalho de , Porto Marianne Colino , Batista Nertan Ribeiro , Feijão Elisabete Lopes , Nóbrega Filho Ricardo Vilar Wanderley , Fernandes Maria Isabel Moreira , Gomes Guilherme de Souza , Pena Carlos Felype de Oliveira , Rodrigues Lorenna Rocha , Bezerra Yves de Carvalho , Crawford Luis Roberto , Vaca Felipe Sanchez , Schultheis Stephanie Ferro , Silva Marlene Alencar da , Andrade Letícia Macedo Nicácio , Alverne Maria da Conceição Azevedo Frota Mont , Torres Iana Araújo , Junior Nilber Acioli de Almeida , Checchinato Daniel , Santos Lisiane Pires Martins dos , Mendes Filho Edivaldo Bezerra , Carvalho Lanna do Carmo
Published: August 2022

Os fármacos antidepressivos compõem o manejo terapêutico da depressão e inúmeros outros transtornos de origem neuropsiquiátrica. Logo, a ocorrências destes distúrbios tornam viável a aplicação destes, ressaltando ser essencial individualizar o tratamento e compreender a respeito das diversas classes, mecanismo de ação, interação medicamentosa, indicação clinica, grupo de risco e a intoxicação por superdosagem. O seguinte artigo objetivou descrever a respeito das particularidades dos antidepressivos, de modo a compreender sobre seu efeito farmacopsiquiatríco. Trata-se de uma revisão narrativa de literatura fundamentada nas renomadas plataformas de artigos indexados a respeito do tema. Foram selecionados os estudos que apresentavam relevância clinica para a compreensão do artigo, descartando-se os demais que não respondiam ao objetivo proposto. Na literatura científica estão disponíveis muitas informações pertinentes ao tema, ressaltando a importância deste. Atualmente, se encontram em aplicabilidade diversas classes que são os Inibidores Seletivos da Recaptação de Serotonina (ISRSs), Antidepressivos Tricíclicos (ADTs), Tetracíclicos e os Inibidores da Monoamina Oxidase (IMAO). Cada um destes possui um mecanismo de ação diferente, mas basicamente estes interferem no impulso nervoso de neurotransmissores beneficiando o portador de distúrbios neurocognitivos. Destacando que mesmo com o efeito terapêutico retrógrado, estes já manifestam os efeitos adversos. Logo, é imprescindível analisar qual o tipo e a dose do fármaco para se conduzir o melhor prognóstico do paciente.
Systemic impact of the post-Coronavirus disease syndrome in Brazil
Authors: Menezes Junior Antonio da Silva , Schroeder Aline Andressa , Rezende Aline Lazara , Santos Luciana da Ressureição , Botelho Silvia Marçal , Teodoro Filho Antonio Marcio Cordeiro
Published: August 2022

Background: Symptom persistence following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been recognized as the post-coronavirus disease (post-COVID-19) syndrome. We aimed to assess the long-term sequelae of COVID-19 in a local Brazilian population, and to identify risk factors for the onset and severity of this syndrome.Methods: This cross-sectional study was conducted in a tertiary-care hospital. Participants who had recovered from COVID-19 underwent a clinical evaluation and completed a questionnaire on post-COVID-19 symptoms that they had experienced.Results: In a sample of 141 patients, the most prominent post-COVID-19 symptoms were associated with the cardiovascular, respiratory, and neurological systems. Participants aged over 40 years had a significantly higher mean number of symptoms than those aged 40 years or younger (14.6 vs. 11.1). Patients with more severe disease in the acute phase, had significantly more symptoms than those with mild or moderate disease. Most post-COVID-19 symptoms were associated with diabetes mellitus (21.8) and renal failure (21.8), but without a significant difference in the number of associated symptoms according to the presence of preexisting comorbidities.Conclusions: Post-COVID-19 syndrome was more common and comprised more symptoms in participants aged over 40 years and in participants with severe disease during the acute phase. Future studies should assess the duration of post-COVID-19 syndrome symptoms and evaluate the impact of COVID-19 vaccination on post-COVID-19 syndrome.
Upaya Meningkatkan Hasil Belajar PJOK Siswa dengan Model Experiental Learning Di Kelas V SD N 71/III Sungai Tanduk Tahun Pelajaran 2015/2016
Authors:   SD N 71/III Sungai Tanduk, Arpani Arpani
Published: August 2022

This study aims to determine students' learning outcome PJOK using experiential learning models in class V SDN 71 / III Horn River district. Kayu Aro District. Kerinci. This research is a classroom action research with research subjects fifth grade students SDN71 / III Horn River numbered 27 people. The object of this study is the implementation and the results obtained from the application of experiential learning models used data collection techniques are observation and tests. Data analysis technique used is descriptive qualitative and quantitative analysis. The results showed that the implementation of learning with experiential learning models can improve student learning outcomes SDN71 class V / III Horn River. Improved learning with experiential learning models in the first cycle of student activity increased 63.87% in the second cycle into 81.48%. The average value of student learning outcomes obtained in the first cycle of 65.56 increased to 72.96 in the second cycle. Students who achieve a value ? 65 on the first cycle as many as 18 people or 62.97%. In the second cycle increased to 23 people or 81.48%. Thus, learning the model of experiential learning on subjects PJOK can be used in class V SDN71 / III Horn River.
Peningkatan Kompetensi Profesional Guru Dalam Menyusun Laporan Penelitian Tindakan Kelas Melalui Model Pembinaan CLCK (Contoh, Latihan, Control, Kerja Mandiri) Berbasis Mentoring Di SDN 03 Batang Gasan
Authors:   SDN 03 Batang Gasan, Dasniati Dasniati
Published: August 2022

Based on observations of the competence of teachers at SDN 03 Batang lascivious in preparing the report on the school action research found that the phenomenon of professional competence of teachers in preparing classroom action research is still low. The purpose of this study is to describe and obtain information about the increase of professional competence of teachers in preparing classroom action research reports through coaching model Clck (Example, Exercise, Control, Self-Employment) based mentoring in SDN 03 Batang Gasan. This research is a school action. The procedure in this research include planning, action, observation and reflection. The study consisted of two cycles of the four meetings. Subjects consisted of 9 The teachers at SDN 03 Batang lascivious. Data were collected by using observation sheet. Data were analyzed using percentages. Based on the results of research and discussion, we can conclude that Clck coaching model based mentoring can improve the ability of teachers in preparing classroom action research report in SDN 03 Batang lascivious. Analysis of the quality of PTK statements made by teachers indicated that the professional competence of teachers in preparing classroom action research reports increased from the first cycle to the second cycle. Professional competence of teachers in preparing classroom action research report on the first cycle was 77.69 (enough) increased to 84.69 (both) on the second cycle with an increase of 7.00 points.
Peningkatan Hasil Belajar Ppkn Melalui Model Pembelajaran Kooperatif Tipe Jigsaw Pada Siswa Kelas IX.1 SMP N 4 Pasaman
Authors:   SMPN 4 Pasaman, Sudirman Sudirman
Published: August 2022

Based on the observations that have been done in SMPN 4 researchers concluded lace Pasaman pembelajaran results due to the lack of effective student learning model used by the teacher in the learning process. To the researchers as a classroom teacher conducts research on cooperative learning model jigsaw on learning outcomes. This research is a classroom action research. The procedure in this research include planning, action, observation and reflection. The study consisted of two cycles of the four meetings. Subject of the study consisted of 23 students. Data were collected by using observation sheet. Data were analyzed using percentages. Based on the analysis of research data that has been presented during two cycles and the results of the entire discussion, it can be concluded that cooperative learning model Jigsaw can improve the quality of teaching Civics and cooperative learning model Jigsaw has a positive impact in improving student learning outcomes characterized by increased mastery learning students in each cycle, the first cycle (68.18%), and the second cycle (90.91%).