bluuebunny/crossref_metadata_2025 huggingface dataset:
Human vs. Artificial intelligence: EU's legal response
Authors: Mladenov Marijana
Published: March 2023

Artificial intelligence (AI) has the capacity to improve not only the individual quality of life, but also economic and social welfare. Although the AI systems have many advantages, they also pose significant risks, creating a wide range of moral and legal dilemmas. The European Union has been creating a legal framework for developing, trading, and using AI-driven products, services, and systems to reduce the risks connected with the AI systems and to prevent any possible harm they may cause. The main focus of this paper refers to the analysis of the Proposal for the Artificial Intelligence Act submitted by the European Commission in April 2021. The goal of the article is to move toward a possible resolution to the dilemma of whether the AIA proposal is appropriate for the AI era by addressing the scope of its application, the prohibited AI practices, rules on high-risk AI systems, specific transparency obligations, as well as certain regulatory gaps. The article should be viewed as an initial analysis of the AIA proposal in order to provide a useful framework for the future discussion.
Green marketing as a determinant of competitive advantages in B2B markets
Authors: Jovičić Dragoljub , Ilić Dragan , Raletić-Jotanović Saša
Published: March 2023

Given the fact that in the professional literature on marketing, and especially in the segment of green (environmental) marketing, much more research is done and written about B2C markets, this paper is an attempt to explore procurement motives and behaviour of business customers during the complex purchasing process, on the example of several important thermotechnical devices, on the B2B market in Vojvodina. The research aims to collect relevant data from business customers through direct interviews regarding the impact of environmental performance on the procurement of gas boilers, heat pumps and air conditioners in order to obtain quality and reliable information based on the process, that is, conducted the descriptive statistical analysis, which will enable a better understanding of this complex issue. To collect qualitative data, the method of the unstructured deep interview was used. The results confirmed the research hypotheses and indicated the necessity of green marketing in current business conditions. It is indisputable that soon only organisations focused on green marketing and green marketing channels, that is to say, those which are focused on creating their own optimal relationship between their production, distribution and/or sales process, and environmental protection, will be able to gain a competitive advantage in dynamic business markets and achieve maximum satisfaction of environmentally demanding customers, and thus, in fact, at the same time give their full contribution to the sustainable development of the entire community.
Musical Aptitude and the Acquisition of Pitch and Duration in L2 Vowels
Authors: Lund Rebecca
Published: March 2023

Music and language have been believed to be processed similarly in the brain. Studies have compared the processing of vowels and music, as they share spectral and temporal features such as pitch and timing. When comparing music and language skills the question arises whether music skills are inherent, measured with aptitude, or acquired, measured with experience. This article focused on musical aptitude studies. It was found that musical aptitude predicted non-native speech-sound processing better than musical experience. It is proposed that music and language skills are interconnected as greater overlaps in neural processing of music and speech were found for musicians than nonmusicians, and as individuals with no musical experience but with high L2 production skills were found to have high musical aptitude. Furthermore, spectral sensitivity was found to be the primary partial mediator of the link between musicality and non-native speech-sound processing, with temporal sensitivity having no role.
On the Role of Confiscation in the Theory of Taxation
Authors: Savina Anna Vladimirovna
Published: March 2023

The formation of modern mechanisms for collecting taxes and fees is a complex process that has gone through many stages of improvement: from forced and unjustified seizures to taxation justified by economic necessity and public interest. The subject of the study is the historical background of the formation of the taxation process in Russia and in a number of foreign countries. To understand the issue under consideration, the author turns to the historical component of such a phenomenon as confiscation. The role of the institution of confiscation in the context of the history of taxes is evaluated. The author explores the problem of legal limits and justifies the importance of their establishment in the field of tax relations. The novelty of the research lies in the comparison of scientific categories, such as "confiscation", "tax", as well as in the formation of an idea of the redistribution of taxation, which is an integral element of effective economic policy.The author studies certain aspects of the theory of effective demand, the theory of monetarism, revealing the contents of the concept of "tax". Conclusions are drawn about the correlation of excessive taxation with the economic downturn, the role of the state in regulating these processes is assessed. The author compares the theory of A. Laffer with the modern mechanism of legal regulation of tax relations, and also summarizes that going beyond taxation creates weakened economic incentives, resistance and tax evasion in society.
Multi-targeted therapy resistance via drug-induced secretome fucosylation
Authors: Aldonza Mark Borris D , Cha Junghwa , Yong Insung , Ku Jayoung , Sinitcyn Pavel , Lee Dabin , Cho Ryeong-Eun , Delos Reyes Roben D , Kim Dongwook , Kim Soyeon , Kang Minjeong , Ku Yongsuk , Park Geonho , Sung Hye-Jin , Ryu Han Suk , Cho Sukki , Kim Tae Min , Kim Pilnam , Cho Je-Yoel , Kim Yoosik
Published: March 2023

Cancer secretome is a reservoir for aberrant glycosylation. How therapies alter this post- translational cancer hallmark and the consequences thereof remain elusive. Here, we show that an elevated secretome fucosylation is a pan-cancer signature of both response and resistance to multiple targeted therapies. Large-scale pharmacogenomics revealed that fucosylation genes display widespread association with resistance to these therapies. In cancer cell cultures, xenograft mouse models, and patients, targeted kinase inhibitors distinctively induced core fucosylation of secreted proteins less than 60 kDa. Label-free proteomics of N-glycoproteomes identified fucosylation of the antioxidant PON1 as a critical component of the therapy-induced secretome (TIS). N-glycosylation of TIS and target core fucosylation of PON1 are mediated by the fucose salvage-FUT8-SLC35C1 axis with PON3 directly modulating GDP-Fuc transfer on PON1 scaffolds. Core fucosylation in the Golgi impacts PON1 stability and folding prior to secretion, promoting a more degradation-resistant PON1. Global and PON1-specific secretome de-N-glycosylation both limited the expansion of resistant clones in a tumor regression model. We defined the resistance-associated transcription factors (TFs) and genes modulated by the N-glycosylated TIS via a focused and transcriptome-wide analyses. These genes characterize the oxidative stress, inflammatory niche, and unfolded protein response as important factors for this modulation. Our findings demonstrate that core fucosylation is a common modification indirectly induced by targeted therapies that paradoxically promotes resistance.
Dally is not essential for Dpp spreading or internalization but for Dpp stability by antagonizing Tkv-mediated Dpp internalization
Authors: Simon Niklas , Safyan Abu , Pyrowolakis George , Matsuda Shinya
Published: March 2023

Dpp/BMP acts as a morphogen to provide positional information in the Drosophila wing disc. Key cell-surface molecules to control Dpp morphogen gradient formation and signaling are heparan sulfate proteoglycans (HSPGs). In the wing disc, two HSPGs, the glypicans Division abnormally delayed (Dally) and Dally-like (Dlp) have been suggested to act redundantly to control these processes through direct interaction of their heparan sulfate (HS) chains with Dpp. Based on this assumption, a number of models on how glypicans control Dpp gradient formation and signaling have been proposed, including facilitating or hindering Dpp spreading, stabilizing Dpp on the cell surface, or recycling Dpp. However, how distinct HSPGs act remains largely unknown. Here, we generate genome-engineering platforms for the two glypicans and find that only Dally is critical for Dpp gradient formation and signaling through interaction of its core protein with Dpp. We also find that this interaction is not sufficient and that the HS chains of Dally are essential for these functions largely without interacting with Dpp. We provide evidence that the HS chains of Dally are not essential for spreading or recycling of Dpp but for stabilizing Dpp on the cell surface by antagonizing receptor-mediated Dpp internalization. These results provide new insights into how distinct HSPGs control morphogen gradient formation and signaling during development.
De Lumine Nocturno Boreali Svetice Nordskien
Authors: Quensel Conrad , Eurodius Hans
Published: March 2023

The file is a facsimile of the original dissertation, with fulltext search functionality embedded in the PDF. For a detailed summary of contents, see the introduction by Per Pippin Aspaas.
Raynaud’s Phenomenon as the Initial and Only Manifestation of Non-Hodgkin Lymphoma: A Case Report
Authors: Parvathy Gauri , Lakshani D.H.J.P.Uresha , Khan Asadullah , Maheshwari Aakansh , Patel Kaivan
Published: March 2023

Raynaud’s phenomenon is one of the commonest manifestations of rheumatic diseases. However, it can be caused by non-Rheumatic conditions as well. Among non-rheumatic causes, cancers are widely reported as the culprit”. Raynaud’s phenomenon caused by non-rheumatic diseases are commonly resistant to standard treatment options They are associated with more severe infections. Among non-rheumatic causes, cancers are widely reported as the culprit. We present a case of non-Hodgkin lymphoma presenting solely with Raynaud’s phenomenon.
Trick or Treat: Curative Management of Esophageal Squamous Cell Carcinoma of a COVID-positive Patient
Authors: Khan Saqib Raza , Nasir Saad , Nauman Zahir Muhammad , Rashid Yasmin Abdul
Published: March 2023

The novel coronavirus pneumonia COVID-19 which is reportedly caused by SARS-CoV-2 infection can potentially lead to a course of clinical symptoms and fatal illnesses. Reported first in 2019, it has now affected more than 596,873,121 people, worldwide. In addition to its clinical manifestation in humans, the COVID-19 virus in cancer patients is significantly declining a positive prognosis. In the time of an ongoing global pandemic, oncologists are struggling to provide appropriate care to cancer patients due to their increased susceptibility to severe complications of COVID-19 which can be attributed to their immunosuppressed status caused by the malignancy and anticancer treatments. Similarly, the lack of literature, evidence, and consensus on whether to give antineoplastic agents to patients with active COVID-19 infection pose a unique challenge for physicians. In this article, we present a case of a 47-year-old female who was diagnosed with squamous cell carcinoma of the esophagus and later tested positive for SARS-CoV-2. Under unanimous decision, oncological treatment for the malignancy was initiated with a combination of chemotherapy and radiation without a consequential delay as per multidisciplinary tumor board (MDT) meeting decision which results in clinical improvement.
Uformell tegning og formell tegneundervisning sett i lys av teori om lek
Authors: Frisch Nina Scott
Published: March 2023

Artikkelen har som mål å belyse tilnærminger til tegning som synliggjør professor Liv Merete Nielsens bidrag til visuell kompetanse i opplæringen ved å belyse barns tegneprosesser ut ifra et sosiokulturelt per­spektiv. Margareta Öhman sosiokulturelle lek-teoretiske bidrag beskriver lekens kjennetegn ut ifra følgende kriterier: Stammen av leken er spontan og frivillig, morsom, krever aktivt engasjement, har ikke tydelige mål, styres av indre motivasjon og gir en følelse av kontroll. Flere av disse karakteristikkene kan kjennes igjen i barnehagebarns og skolebarns uformelle, det vil si selvinitierte og selvstyrte, tegne­pro­sesser i lek med verktøy som blyanter, tusjer, pensler og maling. Problemstillingen er derfor: Hvordan kan uformell tegning forstås som lek og hvordan kan denne forståelsen være med på å støtte barn og el­­ever i visuelt kontrollerte tegneprosesser i formell tegneundervisning? Kasusstudie benyttes som me­to­d­ologisk tilnærming for å utforske to kasus av uformelle tegneprosesser, en fra barnehage og en fra skole. I uformell tegning er det å mestre de samme visuelle uttrykkene ofte en del av leken. Å sammen beherske et univers i leken og å mestre de samme visuelle formuttrykkene ved modellering er en del av funnet. Modellering og mimesis blir en inngang til å kunne knytte trekk ved uformelle tegneprosesser, det Öhman kaller inspirasjon til imitasjon, til den formelle tegneundervisningsarenaen i skole og barn­e­hage. Dette kan være en mulig motivasjon for å lære å tegne, og dermed fremme det professor Liv Nielsen kaller visual literacy, det vil si visuell kompetanse til å skape og forstå bilder og tegninger.
Hilsen
Authors: Skjerven Astrid
Published: March 2023

I den lange tiden jeg har kjent Liv Merete, er det arbeidet med konferansen DRS//cumulus Oslo 2013, med å etablere en PhD-grad og den selvoppnevnte gruppen GrøntMet som jeg husker best. Du er alltid målrettet, men samtidig lyttende og innstilt på å få til løsninger.

Takk for din stå-på-vilje i vanskelige situasjoner og ditt uoppslitelige humør!
Dyktig nettverksbygger, motiverende veileder og klok aktivist
Authors: Moe Harald Eivind
Published: March 2023

Første gang jeg hadde et faglig møte med Liv Merete Nilsen er så langt tilbake som i 1999 da jeg var med på å utvikle The Design of Everyday Life, et undervisningsopplegg på oppdrag for UNESCO i regi av Norsk Form. Det overordnede målet var å bevisstgjøre barn og ungdom om hvordan hverdagen designes for oss, slik at de erverver en kompetanse i å vurdere produktene de tilbys i markedet og omgir seg med. Liv Merete var da fagpolitisk aktiv i det som i dag er organisasjonen Kunst og design i skolen, hvor jeg etter hvert ble valgt inn i styret. Her har hun i mange år vært en viktig drivkraft både som styremedlem, styreleder, og i redaksjonen til tidsskriftet FORM. Etter å ha trukket seg ut av styret har hun videreføre det fagpolitiske arbeidet for organisasjonen − også gjennom den faste spalten LMN har ordet i FORM.
Greetings from Chile
Authors: Bravo Úrsula
Published: March 2023

I met Liv Merete Nielsen at the DRS Limerick 2018 conference. I was studying Chilean teachers' use of design methods to solve pedagogical problems supported by a British Council fund. Peter Lloyd and Derek Jones brought the experience and vision of The Open University's Design Thinking course. They had Nigel Cross as an unavoidable theoretical reference. I also knew Maureen Carroll and Shelley Goldman's work at Stanford University to promote STEM disciplines in vulnerable schools in Palo Alto. Maureen and Shelley built on the IDEO-d.School universe and had Tim Brown and David Kelly as key references.
Kjære Liv Merete
Authors: Hassel Merete
Published: March 2023

Jeg har hatt gleden av å samarbeide med deg gjennom ca. 10 år, helt siden jeg ble ansatt på Nasjonalt senter for kunst og kultur i opplæringen ved Nord universitet i Bodø i 2012. Jeg skjønte raskt at du var en sentral fagperson i UH-sektoren i forhold til fagområdet kunst og håndverk. Selv kommer jeg fra et helt annet fagfelt, nemlig biblioteksektor og sosialantropologi, og jeg har senere beveget meg inn i tilpasset opplæring og det spesialpedagogiske feltet. Ved senteret fikk jeg blant annet oppgaver knyttet til forskningsformidling. Nysgjerrigheten for å hele tiden utvide vår kompetanse og lære nye ting er vel noe vi har felles.
Association between ACE and ACTN3 genes polymorphisms and athletic performance in elite and sub-elite Chinese youth male football players
Authors: Yang Shidong , Lin Wentao , Jia Mengmeng , Chen Haichun
Published: March 2023

Background

Previous studies have shown controversial relationships between ACE I/D and ACTN3 R577x polymorphisms and athletic performance. Therefore, the aim of this study was to assess athletic performance indicators of Chinese youth male football players with different ACE and ACTN3 gene profiles.

Methods and Materials

This study recruited 73 elite (26 13-year-olds, 28 14-year-olds, and 19 15-year-olds) and 69 sub-elite (37 13-year-olds, 19 14-year-olds, and 13 15-year-olds) and 107 controls (63 13-year-olds, and 44 14-year olds aged 13–15 years, all participants were of Chinese Han origin. We measured height, body mass, thigh circumference, speed, explosive power, repeat sprints ability, and aerobic endurance in elite and sub-elite players. We used single nucleotide polymorphism technology to detect controls elite and sub-elite players’ ACE and ACTN3 genotypes, Chi-squared (χ2) tests were employed to test for Hardy-Weinberg equilibrium. χ2 tests were also used to observe the association between the genotype distribution and allele frequencies between controls and elite and sub-elite players. The differences in parameters between the groups were analyzed using one-way analysis of variance and a Bonferroni’s post-hoc test, with statistical significance set at p ≤ 0.05.

Results

(1) The genotype distribution of the ACE I/D and ACTN3 R577x polymorphisms in controls, elite and sub-elite football players were consistent with Hardy-Weinberg equilibrium, except for the ACE genotype distribution of sub-elite players. (2) The RR and DD genotypes were significantly different between elite and sub-elite players (p = 0.024 and p = 0.02, respectively). (3) Elite players were more likely to have the RR genotype and less likely to have the DD genotype compared with sub-elite players. (4) Both elite and sub-elite RR players’ Yo-yo intermittent recovery level 1 (YYIR1) running distance was significantly longer than that of RX players (p = 0.05 and p = 0.025, respectively). However, there was no significantly different in YYIR1 running distance between elite and sub-elite RR players. (5) Elite XX players’ VO2 max was significantly higher than that of RX and sub-elite players.

Conclusion

These results indicate that ACE I/D and ACTN3 R577x polymorphisms are not associated with muscle power in Chinese elite and sub-elite players. The XX genotype of ACTN3 is associated with the aerobic endurance of elite players.
A new model predicts hepatocellular carcinoma in patients with HBV-related decompensated liver cirrhosis and long-term antiviral therapy: a prospective study
Authors: Mao Hao-dan , Zheng Shu-qin , Yang Su-hua , Huang Ze-yu , Xue Yuan , Zhou Min
Published: March 2023

Background

We aimed to evaluate the prediction values of non-invasive models for hepatocellular carcinoma (HCC) development in patients with HBV-related liver cirrhosis (LC) and long-term NA treatment.

Methods

Patients with compensated or decompensated cirrhosis (DC), who achieved long-term virological response, were enrolled. DC and its stages were defined by the complications including ascites, encephalopathy, variceal bleeding, or renal failure. Prediction accuracy of several risk scores, including ALBI, CAMD, PAGE-B, mPAGE-B and aMAP, was compared.

Results

The median follow-up duration was 37 (28–66) months. Among the 229 patients, 9 (9.57%) patients in the compensated LC group and 39 (28.89%) patients in the DC group developed HCC. The incidence of HCC was higher in the DC group ($\cal X$2 = 12.478, P < 0.01). The AUROC of ALBI, aMAP, CAMD, PAGE-B and mPAGE-B scores were 0.512, 0.667, 0.638, 0.663, 0.679, respectively. There was no significant difference in AUROC between CAMD, aMAP, PAGE-B and mPAGE-B (all P > 0.05). Univariable analysis showed that age, DC status and platelet were associated with HCC development, and multivariable analysis showed that age and DC status (both P < 0.01) were independent risk factors for HCC development, then Model (Age_DC) was developed and its AUROC was 0.718. Another model, Model (Age_DC_PLT_TBil) consisting of age, DC stage, PLT, TBil was also developed, and its AUROC was larger than that of Model (Age_DC) (0.760 vs. 0.718). Moreover, AUROC of Model (Age_DC_PLT_TBil) was larger than the other five models (all P < 0.05). With an optimal cut-off value of 0.236, Model (Age_DC_PLT_TBil) achieved 70.83% sensitivity, 76.24% specificity.

Conclusion

There is a lack of non-invasive risk scores for HCC development in HBV-related DC, and a new model consisting of age, DC stage, PLT, TBil may be an alternative.
Profile of Arteriovenous Fistula Surgery in Patients with Chronic Kidney Disease at a Tertiary Care Urology Hospital Karnataka, India: A Prospective Interventional Study
Authors: Narendra JB , Narkhede Mayur M , Soni Dhruvit K
Published: March 2023

Introduction: Haemodialysis (HD) is the most important treatment approach in patients with Chronic Kidney Disease (CKD), awaiting kidney transplantation, demanding the longterm need for dialysis access. Aim: To study the profile of Arteriovenous Fistula (AVF) surgery in patients undergoing haemodialysis in the Karnataka region, India. Materials and Methods: This prospective, interventional singlecentre study was conducted at the Institute of Nephrology and Urology, KR Hospital Campus, Mysuru, India, from April 2018 to April 2021. All the patients undergoing haemodialysis with AVF aged between 11-90 years were included. Demographic details (age, sex, co-morbidities) and fistula-related complications associated with surgery were examined in the immediate, late, and delayed postoperative period. Categorical variables were presented as numbers and percentages whereas, continuous variables were expressed as mean {Standard Deviation (SD)}. The data was collected in Excel Sheet and the statistical analysis was performed using Statistical Package for Social Sciences (SPSS), version 20.0. Results: In total, 200 patients with a mean (SD) age of 48.8 (13.0) years underwent AVF formation and the majority were below <60 years of age (n=154, 77.0%). The incidence of fistula surgery and patency rates was higher in men (n=140, 70.0%). Most patients had left non dominant arm (n=187, 93.5%) and remaining right non dominant arm (n=13, 6.5%). The most common site of AVF was left brachial cephalic (n=135, 67.5%). The most common cause of CKD was diabetes mellitus (n=90, 45.0%). The most common immediately observed complications were bleeding (n=13, 6.5%), pain (n=12, 6.0%) and oedematous limb (n=5, 5.0%). Stitch abscess was the most common late complication observed in 14 patients (7%). Rupture of the aneurysm and AVF failure were delayed complications observed in eight (1.5%) and 17 (8.5%) patients, respectively. Conclusion: In this study, bleeding, stitch abscess and AVF failure were found to be the most common immediate, late, and delayed postoperative complications, respectively. However, more studies are required to understand the outcome of AVF in Chronic Renal Failure (CRF) patients from India.
Comparative Evaluation of Fracture Resistance of Maxillary Premolars with Class II Cavities Restored with Glass Hybrid Restorative System and Nanohybrid Composite Resin: An In-vitro Study
Authors: Savaliya Krushn , Kishan Karkala Venkappa , Shroff Manan Gaurang , Saklecha Purnima , Mavani Harshit Tushar , Kaur Supreet , Volety Shreya
Published: March 2023

Introduction: Maxillary premolars are the most susceptible teeth to fracture if both marginal ridges are compromised. Composite restorations have performed remarkably in restoring the marginal ridges. However, it has certain disadvantages, thus to overcome this, modified glass ionomer based restorative materials with improved mechanical properties were introduced. Aim: To compare and evaluate the fracture resistance of maxillary premolars with class II Mesio-Occluso-Distal (MOD) cavities which received Glass hybrid restorative system and Nanohybrid Composite resin. Materials and Methods: The present study was an in-vitro study at KM Shah Dental College and Hospital, Vadodara, Gujarat from December 2019 to June 2020, on 30 Extracted Maxillary premolars were selected. Total samples were divided into group A (n=15) restored by glass hybrid restorative system and group B (n=15) restored by nanohybrid composite resin. Standardised class II MOD Cavity preparation was done in all the samples. The samples were subjected to a thermocycling procedure, and a universal testing machine measured the fracture resistance. Data obtained from all the samples was analysed by Independent sample t-test with a p-value set at less than 0.05. Results: In group A, mean fracture resistance (at mean force 947.07±236.41) was found to be greater than in Group B. However, the difference among the groups was not statistically significant with a p-value of 0.555. Conclusion: Glass Hybrid restorative system showed better fracture resistance than Nanohybrid Composite Resin in maxillary premolars with class II MOD Cavities.
Assessment of Relationship between Saphenofemoral Junction Reflux and Great Saphenous Vein Diameter using Doppler Ultrasonography in Patients with Chronic Venous Disease: A Cross-sectional Study
Authors: Aiyappan Senthil Kumar , Rajendraprabhu Ashwini , Mittal Harshika , Kumar Deepthi Arun , Prabakaran Linnet , Rajagopal Revathi
Published: March 2023

Introduction: Chronic venous disease is a commonly occurring disease that includes a variety of pathological conditions like varicose veins, oedema, skin abnormalities, and ulceration, among which the most prevalent are the varicose veins. Doppler imaging is presently the first investigation for evaluating chronic venous disease. Aim: To investigate the relationship between Saphenofemoral Junction (SFJ) reflux and Great Saphenous Vein (GSV) diameter in patients with chronic venous disease and to determine the best cut-off value of GSV diameter in predicting reflux. Materials and Methods: The present cross-sectional study was conducted in the Department of Radiology, SRM Medical College and Hospital, Tamil Nadu, India, from December 2019 to June 2021 on 76 patients with chronic venous disease. The study was conducted on a GE Logic P9 ultrasound machine, the diameter of GSV was measured close to the SFJ, at the Proximal Thigh (PT); 15cm distal to the SFJ, and at the calf. The diameter of the GSV was compared with the presence of SFJ reflux. Similarly, Short Saphenous Vein (SSV) diameter was also measured posterior to the knee and was correlated with Saphenopopliteal Junction (SPJ) reflux. Chi-square and student t-tests were used for analysis with a cut-off value determined through Receiver Operating Characteristic (ROC) curve analysis. Results: The mean age of study participants was 51±15.85 years with age range of 19 years to 78 years. Of total, 42 (55.26%) had chronic venous insufficiency on the left side and 34 (44.74%) had on the right side. The mean GSV diameter at SFJ and at PT was higher in patients with SFJ incompetence and was statistically significant with a p-value of 0.001 and 0.002, respectively by t-test. Although the mean GSV diameter at calf was higher in patients with SFJ incompetence, it was statistically insignificant. The GSV diameter at the SFJ had the best cut-off value for predicting incompetence, with a mean diameter of 5.95 mm with 76.3% sensitivity and 76.3% specificity. The cut-off of SSV at the posterior knee for predicting SPJ incompetence was 4.6 mm which had a sensitivity of 72.7% and specificity of 88.7% and diagnostic accuracy of 86.84%. Conclusion: The GSV diameter at SFJ and PT help in predicting SFJ incompetence. The SSV diameter at SPJ aids in predicting SPJ incompetence.
Verrucous Hyperplasia Masquerading as a Verrucous Carcinoma: A Diagnostic Challenge
Authors: Tharani Vijaykumar , Nandhini G , Dinesh Snehesh , Vinitha KB
Published: March 2023

Verrucous Hyperplasia (VH) is a rare exophytic oral mucosal lesion that can progress to Verrucous Carcinoma (VC) and it has increased probability of converting into Squamous Cell Carcinoma (SCC). These lesions present diagnostic difficulties to the clinician. In diagnosing this, histopathology remains the gold standard. In VH cases, these entities can be distinguished by the lack of invasive growth; as a result, when performing a biopsy of the lesion's epithelium, it is critical to include a margin with adequate depth. Therefore, it is pivotal that biopsies of verrucous lesions include a lesional margin with adequate depth. The present case report discusses about the VH, a 53-year-old male patient presented with a complaint of non healing growth in the left lower back tooth region. During clinical examination, well-defined oval soft growth with cauliflower like projections on the surface was present and measured 2×1 cm with well-defined borders. Treatment plan includes surgical excision. The lesion was sent for histopathological examination and the final diagnosis was made. The patient was reviewed for three months, no recurrence of the lesion was observed during the follow-up period.
PHYSICS IN MEDICINE AND ECONOMY OF CONTEMPORARY SOCIETY
Authors: CZYŻ Henryka , JASIŃSKI Tadeusz
Published: March 2023

This paper describes the main methods of separating blood into components. The most common methods used in medicinal practice include centrifugation and filtration. Currently, there has been a lot of research on the application of ultrasound as the new, innovative method of separation of blood components. Ultrasound use is a theoretically elaborated method and experimental research is in process with the aim of its implementation in medical diagnostics. Contemporary societies are aware of the importance of findings of physics as well as of the fact that our everyday life is strongly connected to physics and to technical devices that have been created on the basis of its fundamental laws.
PROOF OF NON-EXISTENCE OF SELF-IMAGING PHENOMENON IN THE INCOHERENT CASE
Authors: MAMCZUR Jan A.
Published: March 2023

The existing description of incoherent wave field propagation in terms of Fourier transformation has made possible to prove non-existence of the self-imaging phenomenon for incoherent images.
A NEW ALGORITHM FOR TESTING THE PROPERTIES OF NONWOVEN FABRICS
Authors: SOKOŁOWSKI Aleksander , WIĘCEK Tomasz
Published: March 2023

The new algorithm to study the properties of nonwoven fabrics is presented in the paper. The algorithm consists in image processing of the image of the highlighted nonwoven fabric. From the image there are selected the bright areas, which means sparse distributions of the fibers. Because nonwoven fabrics are used, among others, as medical and filtration materials their structure has significant impact on their ownership. The software task is primarily determine the porosity of the material.
REZONANSOWA DIODA TUNELOWA Z ELEKTRODAMI MAGNETYCZNYMI
Authors: SZCZEPAŃSKI Tomasz , KUDŁA Sylwia
Published: March 2023

Przedstawiono podstawowe własności transportu ładunku i spinu poprzez wielowarstwowe struktury półprzewodnikowe, zawierające warstwy izolatorów. Układ półprzewodników przedzielonych warstwą izolatora stanowi rodzaj złącza tunelowego, poprzez które cząstki przedostają się wykorzystując zjawisko tunelowania kwantowego. Za pomocą dwóch złącz tunelowych zawierających bariery energetyczne w postaci materiału izolatora, konstruujemy kwantową studnię potencjału. W jej obszarze poziomy energetyczne ulegają skwantowaniu, przyjmując wyłącznie wartości dyskretne lub quasi-dyskretne. Ponadto prawdopodobieństwo tunelowania ładunków przez układ zawierający studnię potencjału zależy od tego czy energia padających cząstek znajduje się w koincydencji z dozwolonym w jamie tzw. rezonansowym poziomem energetycznym. Tego typu systemy stanowią podstawę funkcjonowania tzw. rezonansowych diod tunelowych. Przeanalizowano zależności od różnych parametrów układu, takich jak energia poziomu rezonansowego, szerokość barier potencjału, oraz wpływ pola magnetycznego na elektryczne oraz spinowe własności transportowanych cząstek. Badania te mają kluczowe znaczenie w projektowaniu urządzeń na potrzeby spintroniki. Wykorzystują one polaryzację spinową prądu, akumulację spinu w studniach potencjału, manipulowanie spinem w układach elektronicznych przy wykorzystaniu pola magnetycznego oraz indukowanie magnetyzacji w obszarze studni kwantowej zawierającej rozszczepione spinowo poziomy rezonansowe.
A ARTE DE DIDE BRANDÃO NA IGREJA IMACULADA CONCEIÇÃO: CIDADE DE ITAJAÍ
Authors: Ignácio Carlos Eduardo
Published: March 2023

O texto aborda a arte de José Bonifácio Brandão – Dide Brandão (1924-1976) – na Igreja Imaculada Conceição na cidade de Itajaí, com o objetivo de propalar sua obra, a criação do curato e a edificação da primeira igreja da cidade. Tem por objetivo analisar a criação da cidade de Itajaí e do artista local sob a ótica de Giulio Carlo Argan (1909-1992) no que tange ao surgimento das cidades e de Giorgio Vasari (1511-1574) com relação à “Vida dos Artistas”. A Igreja Imaculada Conceição, patrimônio cultural itajaiense, será vislumbrada em suas raízes, indícios e sinais examinados no “Paradigma Indiciário” de Carlo Ginzburg (1939). Considerar o artista local Dide Brandão nas reflexões do ensaio “A Morte do Autor”, de Roland Barthes (1915-1980) é outro intuito. O estudo guia-se metodologicamente pela fenomenologia de Maurice Merleau-Ponty (1908-1961). Almeja apresentar discussões acerca do lugar da obra, constituída na Igreja Imaculada Conceição ou na arte de Dide Brandão e elucidar os conceitos de autor e autoria. O resultado enfatiza um recorte das obras do artista, aquela que consta na primeira igreja da cidade de Itajaí.
“SOMOS AS SUPER DRAGS E VIEMOS DAR... O CLOSE CERTO!": UMA ANÁLISE DOS ENUNCIADOS DISCURSIVOS LGBTQIA+ NA ANIMAÇÃO SERIADA SUPER DRAGS
Authors: Junior Claudinei Lopes , Da Silva Mandaji Carolina Fernandes
Published: March 2023

Este trabalho tem como objetivo central analisar discursivamente os enunciados do discurso LGBTQIA+ no primeiro episódio, intitulado Hora do Lipsync, da primeira temporada da série Super Drags, produzida e distribuída pela plataforma Netflix no ano de 2018. Precedendo a apresentação do aparato teórico-metodológico de análise fundamentalizado na Análise do Discurso (AD) e levando em consideração que nosso objeto de estudo se configura como um produto cultural audiovisual seriado cuja linguagem explorada é a animação e se encontra disponibilizado em uma plataforma de streaming, a reflexão teórica se ancora sobre tais domínios. Como resultados, destaca-se principalmente o teor de resistência e de representatividade que permeiam as escolhas narrativas e discursivas nos enunciados LGBTQIA+ de Super Drags de modo a incitar visibilidade a tal comunidade e discutibilidade de suas pautas.
Assessment of Farmers’ Resilience to Climate – Related Disasters in Oyo State, Nigeria
Authors: S. Amusat, A. , K. Amusat, K. , T. Omisope, E.
Published: March 2023

The study assessed farmers’ resilience to climate related disasters in Oyo State, Nigeria. Simple random sampling technique was used to select 153 farmers from the list of those who have previously experienced climate related disaster in the state. Results indicate that 58.8% of the respondents were male, 37.3% did not have formal education, 80.4% were married and 59.4% used family labour. Majority (85.0%) were not aware of agricultural insurance scheme while 49.0% were aware of emergency response scheme of the government. The most available resilience options to farmers were improve variety of seeds (88.2%) and agro technologies (88.2%) while the most frequently experienced climate related disaster were drought (=1.20) and flood (=1.18). Also, drought (=1.38) and flood ( =1.37) were the most severe among the climate related disaster experienced in the study area while respondents had high capacity to mitigate pest infestation (=2.72) and forest fire (= 1.80). Low level of knowledge ( =1.50) and poor response from emergency management of governments (=1.46) were the major constraints to mitigation of climate related disaster in the study area. Significant relationship existed between respondents’ education (χ2=16.34;P=0.001) and their resilience to climate related disaster. Efforts should be made to provide capacity building for farmers on possible ways of mitigating negative effects of climate change in the study area.
Antibiotics Profile and Public Health Implication of Pathogenic Enteric Bacteria Associated With Poultry Stool
Authors: Zige Douye Victor , Omeje Faith Iyeoma
Published: March 2023

Poultry waste are not properly disposed and most rural farmers make use of it as manure therefore poultry wastes may serve as source of enteric organism capable of infecting humans. The antibiotic resistance from these bacteria can be transferred to natural microbial community as a result of involvement of antibiotics in poultry farming. This research was carried out to assess the multidrug resistant pattern of enteric bacteria in poultry stool dropping. samples of poultry droppings were obtained from a free-range commercial poultry farm in Otuoke, Bayelsa State, Nigeria. Samples were cultured on selective and differential media. 16 isolates of enteric bacteria were obtained from poultry stool droppings. The isolates identified were of four genera. Salmonella species which is predominant 6(37%) followed by Escerichia coli 5(31%) Proteus species 3(19%) and Kiebsiella species 2(13%). Antibiotic susceptibility testing was carried out using the disk diffusion technique. Gram negative antibiotics including crioxacin cefprozil, nitrofuration, ceftazidime co-trimoxazole, genetamicin, cefuroximo. The resistant pattern in among the gram negative pathogens revealed that more than 98% were resistant to nitrofuratioin cefprozil, gentamicin and augumentin while 12.89% resistant to certazidime, 90.10% resistant to augmentin, 15.32% cefuroxime, 12.30% co-trimoxazole, 38.17% resistant to gentamicin, 15.20% resistant to cefprozil and 50.20% resistant to ofloxacin, Multidrug resistance species were isolated from poultry stool dropping and some of the bacterial isolates are potentially pathogenic to humans and animals and therefore poses a serious threat to public health.
Excavation and publication: some comments
Authors: Alcock Leslie
Published: March 2023

An excavator's skills cannot be assessed from even a full excavation report: the primary aim of archaeological publication is to make information available, not to encourage the impossible task of 'site reconstruction'. Moreover very few readers have the time or need to grapple with complex detail, even if they can afford the high costs of such reports. Hence conventional methods of publication in the 'Cranborne Chase manner' should be abandoned in favour of depositing a comprehensive primary report to publishable standard in an archive, with copies available in microform on demand. Only a distillation of this report would be printed in book or journal form.
Association Between Hospital Adoption of an Emergency Department Treatment Pathway for Opioid Use Disorder and Patient Initiation of Buprenorphine After Discharge
Authors: Solomon Keisha T. , O’Connor Jason , Gibbons Jason B. , Kilaru Austin S. , Feder Kenneth A. , Xue Lingshu , Saloner Brendan , Stuart Elizabeth A. , Cole Evan S. , Hulsey Eric , Meisel Zachary , Patel Esita , Donohue Julie M.
Published: March 2023

Importance

Emergency department (ED)–based initiation of buprenorphine has been shown to increase engagement in outpatient treatment and reduce the risk of subsequent opioid overdose; however, rates of buprenorphine treatment in the ED and follow-up care for opioid use disorder (OUD) remain low in the US. The Opioid Hospital Quality Improvement Program (O-HQIP), a statewide financial incentive program designed to increase engagement in OUD treatment for Medicaid-enrolled patients who have ED encounters, has the potential to increase ED-initiated buprenorphine treatment.

Objective

To evaluate the association between hospitals attesting to an ED buprenorphine treatment O-HQIP pathway and patients’ subsequent initiation of buprenorphine treatment.

Design, Setting, and Participants

This cohort study included Pennsylvania patients aged 18 to 64 years with continuous Medicaid enrollment 6 months before their OUD ED encounter and at least 30 days after discharge between January 1, 2016, and December 31, 2020. Patients with a claim for medication for OUD 6 months before their index encounter were excluded.

Exposures

Hospital implementation of an ED buprenorphine treatment O-HQIP pathway.

Main Outcomes and Measures

The main outcome was patients’ receipt of buprenorphine within 30 days of their index OUD ED visit. Between August 2021 and January 2023, data were analyzed using a difference-in-differences method to evaluate the association between hospitals’ O-HQIP attestation status and patients’ treatment with buprenorphine after ED discharge.

Results

The analysis included 17 428 Medicaid-enrolled patients (female, 43.4%; male, 56.6%; mean [SD] age, 37.4 [10.8] years; Black, 17.5%; Hispanic, 7.9%; White, 71.6%; other race or ethnicity, 3.0%) with OUD seen at O-HQIP–attesting or non–O-HQIP–attesting hospital EDs. The rate of prescription fills for buprenorphine within 30 days of an OUD ED discharge in the O-HQIP attestation hospitals before the O-HQIP intervention was 5%. The O-HQIP attestation was associated with a statistically significant increase (2.6 percentage points) in prescription fills for buprenorphine within 30 days of an OUD ED discharge (β, 0.026; 95% CI, 0.005-0.047).

Conclusions and Relevance

In this cohort study, the O-HQIP was associated with an increased initiation of buprenorphine in patients with OUD presenting to the ED. These findings suggest that statewide incentive programs may effectively improve outcomes for patients with OUD.
Single‐cell transcriptome analysis of male chicken germ cells reveals changes in signaling pathway‐related gene expression profiles during mitotic arrest
Authors: Choi Hyeon Jeong , Jung Kyung Min , Park Kyung Je , Lee Kyung Youn , Woo Seung Je , Han Jae Yong
Published: March 2023

Mitotic arrest is necessary for the embryonic development of germ cells, and thus, it is important to understand the signaling pathways that regulate mitotic arrest. Here, we investigated the signaling pathway dynamics of male embryonic chicken germ cells during mitotic arrest by single‐cell transcriptome analysis using germ‐cell tracing models. We identified signaling pathways that change at the transcriptional level during chicken male germ‐cell development after sex determination. We found that several components of the BMP, Notch, and JAK–STAT signaling pathways were downregulated at the mitotic‐arrest stage and were reactivated 1 week after hatching when all germ cells are quiescent after entering mitotic arrest. In addition, the transcriptional levels of components of the MAPK, Hedgehog, and thyroid‐hormone signaling pathways were steadily upregulated after mitotic arrest. This suggests the cooperation of multiple signaling pathways during entry into mitotic arrest and subsequent quiescence of chicken male germ cells.
AAAP: Keep OTPs in charge, but don't allow nonphysicians to prescribe
Authors: Knopf Alison
Published: March 2023

The American Academy of Addiction Psychiatry (AAAP), in commenting on methadone reforms proposed by the federal government, has warned against unintended consequences of making it too easy to access methadone, and wants more studies done on liberalized take‐home doses, but the main opposition to the proposal was opening up prescribing to nonphysicians.
Comprehensive Measurement of the Adhesion between Ice or Glass and Model PDMS Coatings
Authors: Bellido-Aguilar Daniel Angel , Safaripour Maryam , VanDonselaar Kurt , Ndunagum Leo-Stanley Chibuike , Webster Dean C. , Croll Andrew B.
Published: March 2023

Ice accretion is an unavoidable phenomenon that endangers the performance of outdoor infrastructure and vehicles at low temperatures. To combat ice accretion, the use of anti‐icing coatings has been one of the most appealing approaches because of their simplicity. Silicone elastomers have been increasingly employed due to their natural hydrophobicity, simple preparation, and low price. However, most of the characterization of silicone‐based polymers and other anti‐icing coatings has been done using unproven techniques that often do not directly relate to materials’ properties. In this work, the adhesion between glass and ice and four PDMS‐based elastomers has been studied by a combination of a macroscale shear test, a microscale technique (the Johnson–Kendall–Roberts (JKR) approach), and a commonly used push‐off test. Results are obtained at different temperatures and, importantly, different test velocities. The shear tests yield an energy release rate (the material's property related to adhesion) in the range of 1–10 J m−2, whereas the quasistatic JKR test yields values in the 0.1–0.5 J m−2 range for glass/PDMS interfaces. Ice/PDMS interfaces are found to have larger energy release rates in shear tests and lower values in quasistatic JKR tests. Both differences can be attributed to differences in interfacial crack dynamics.
A Boronate Ester Driven Rechargeable Antibacterial Membrane for Fast Molecular Sieving
Authors: Yi Ming , Nguyen Thi Dao , Liu Huan , Liu Yafang , Xiong Shu , Wang Yan
Published: March 2023

Membrane decorated with biocides is an effective way to suppress biofilm growth. However, their immediate biocidal effect usually suffers from a significant decline due to the irreversible consumption of the biocides. Here, a smart nanofiltration membrane is reported with rechargeable antibacterial capability that is fabricated by a facile interfacial polymerization via 3‐aminophenylboronic acid and trimesoyl chloride on a polysulfone substrate. Biocides bearing diol groups can be grafted onto the membrane surface under neutral/alkaline condition and then released from the surface under acidic environment, due to the pH‐responsive feature of boronate ester complexes. The resultant membrane exhibits integrated properties of fast bacterial inactivating efficiency, rechargeable antibacterial capability, and impressive stability. In addition, the achieved membrane shows remarkable separation efficiency to dye/monovalent salt system. The successful fabrication of the membrane with rechargeable anti‐bacterial property provides new insights into the development of pH‐responsive and sustainable antibacterial membranes.
Comment on “Vapor Lubrication for Reducing Water and Ice Adhesion on Poly(dimethylsiloxane) Brushes”: Vapor Alteration Alone Reduces Water Droplet Adhesion
Authors: Khatir Behrooz , Golovin Kevin
Published: March 2023

A reduction in lateral adhesion of water droplets on poly(dimethylsiloxane) (PDMS) brush surfaces exposed to various vapor conditions was recently reported. It was suggested that the mobility of droplets is due to swelling of the PDMS brushes. When changing the vapor surrounding sliding droplets on bare surfaces, a similar phenomenon is observed, presenting a much simpler explanation of the observed results.