bluuebunny/crossref_metadata_2025 huggingface dataset:
Development Of Interactive Media With Contextual Teaching Learning To Enhance Vocational Schools Student Creativity In Malang
Authors: Rusilawati Devi , Ar Rosyid Harits , Mohd Zaki Nurul Izzah Idayu Binti
Published: June 2023

Basic Graphic Design is one of the compulsory subjects that must be taken by students of class X Multimedia Department at SMK Negeri 7 Malang. This research and development aim to produce products in the form of interactive media containing Contextual Teaching Learning (CTL) Basic Graphic Design subjects to foster creativity. This type of research and analysis is included in mixed or quantitative and qualitative research. The Research and Development model used is the ADDIE model. The development procedure is (1) Analyze; (2) Design; (3) Development; (4) Implementation; (5) Evaluation. The results of the validation by material experts were 88.75 percent, media experts 95 percent, small group trials 83.18 percent, large group trials 87.69 percent. Therefore, it can be concluded that the basic interactive media of Graphic Design with CTL is suitable for use as a student learning medium. Based on the results of the study as long as students used interactive media, it was found that 19 students (63 percent) had high creativity, 10 students (33 percent) had moderate creativity, and 1 student (3 percent) had low creativity. This indicates that the use of interactive media has been able to foster student learning creativity in general
Computer and Network Engineering Expertise Competency Test Program Evaluation at Islamic Vocational School 1 Blitar
Authors: Winarsih Eny , Widiyaningtyas Triyanna , Ahmad Johan Nur Ain Izzaty Binti
Published: June 2023

Competency test is an assessment to measure the competence of students at a certain level according to the competence of skills possessed by SMK. This study uses the DEM (Discrepancy Evaluation Model) research model with a qualitative research type that was carried out during the implementation of the Expertise Competency Test (UKK) of the Computer and Network Engineering (TKJ) Expertise Program at Islamic Vocational School 1 Blitar. The sources of data in this study were TKJ teachers, TKJ Field Coordinators, the implementing committee, internal assessors, external assessors, and students. Methods of data collection using observation, questionnaires, interviews, and documentation. Data processing techniques are carried out qualitatively according to what is happening in the field. The results of the evaluation of the implementation of the Expertise Competency Test of the Computer and Network Engineering Expertise Program at SMK Islam 1 Blitar are as follows: (1) the design development stage has been very well carried out, (2) the installation stage is included in the very appropriate category and is suitable for use as a skill competency test. , (3) the overall process stage is in accordance with the UKK scheme designed by the school, (4) the overall product stage is also very in line with the UKK terminal objectives to be implemented. (5) The cost analysis stage can be obtained that the costs incurred by the school are issued based on the needs of the test by considering the infrastructure owned by the school and are still suitable for use in the test
Evaluation of triglyceride-glucose index in coronary slow flow patients
Authors: Yuksel Yasin , Yildiz Cennet
Published: June 2023

Aim    Triglyceride glucose index (TyG index) is a surrogate marker for insulin resistance. No studies have evaluated the TyG index in patients with coronary slow flow phenomenon (CSFP). We investigated TyG index values in CSFP and evaluated whether it had a predictive value for the diagnosis of CSFP.Material and Methods    132 CSFP patients and 148 subjects with normal coronary arteries were included in the study. Thrombo­lysis in myocardial infarction frame count (TFC) of each patient was calculated. Demographic, clinical features, information regarding medication use and biochemical variables of the patients were obtained from hospital records.Results    TyG index of patients with CSFP and normal coronary flow were 9.02 (8.65–9.42) and 8.69 (8.39–9.18), respectively (p<0.001). Mean TFC showed positive correlation with the TyG index, glucose, triglyceride, and hemoglobin concentration (r=0.207, r=0.138, r=0.183, r=0.179 and p<0.001, p=0.020, p=0.002, p=0.003, respectively) and negative correlation with high density lipoprotein-cholesterol (HDL–C) level (r=–0.292, p<0.001). Receiver operating characteristic curve analysis of TyG index demonstrated that the value of 8.68 predicted CSFP curve analysis of TyG index demonstrated that the value of 8.68 predicted CSFP with sensitivity of 74.2 % and specificity of 58.6 %. In multivariate logistic regression analysis, HDL–C, hemoglobin and the TyG index were the independent predictors of CSFP.Conclusions    Our findings supported the hypothesis that insulin resistance play role in CSFP.
Cost-effectiveness of pneumococcal vaccination among patients with chronic heart failure
Authors: Rudakova A. V. , Brico N. I. , Lobzin Yu. V. , Namazova-Baranova L. S. , Avdeev S. N. , Kostinov M. P. , Korshunov V. A. , Fomin I. V.
Published: June 2023

Aim      To analyze the cost-effectiveness of pneumococcal vaccination in 40- and 65-year-old patients with chronic heart failure (CHF).

Material and methods  Analysis was performed by Markov modeling from the perspective of the healthcare system. The evaluation was based on Russian epidemiological data taking into account results of international studies. The analyzed schedule of vaccination included one dose of 13-valent pneumococcal conjugate vaccine (PCV13) followed by 23-valent polysaccharide vaccine (PPSV23) after one year and vaccination with only one dose of PCV13. The time horizon of the study was 5 years. Costs and life expectancy were discounted at 3.5% per year.

Results The cost-effectiveness of vaccination for both 65-year-old and 40-year-old CHF patients is very high: the incremental cost of one additional QALY (Quality-Adjusted Life Year) for PCV13+PPSV23 vaccination is 113.24 thousand rubles, while vaccination with PCV13 entails a reduction in costs by 556.50 rubles per one vaccinated patient. For vaccination of 40-year-old CHF patients with PCV13+PPSV23, the incremental costs per 1 QALY will be 519.72 thousand rubles, while for vaccination with PCV13 it will be 99.33 thousand rubles.

Conclusion      Pneumococcal vaccination of CHF patients reduces the associated morbidity and mortality and is highly cost effective.
Markers of redox potential of blood leukocytes in acute coronary syndrome, depending on the presence of type 2 diabetes mellitus
Authors: Semenova P. A. , Nevzorova V. A. , Plekhova N. G. , Chernenko I. N. , Potapova E. S. , Ivanchuk U. S.
Published: June 2023

Aim      Evaluating the redox potential of white blood cells (WBC) in acute coronary syndrome (ACS) depending on the presence or absence of type 2 diabetes mellitus (DM2).

Material and methods  The study included 100 men and women aged 35 to 65 years who were managed for ACS at the Primary Vascular Department (PVD) of the Vladivostok Clinical Hospital #1. The control group consisted of 30 healthy volunteers matched with ACS patients in major anthropometric characteristics. Examinations were performed according to clinical recommendations. Blood was withdrawn for measuring cell activity of enzymes (superoxide dismutase, SOD; succinate dehydrogenase, SDH; and glutathione reductase, GR) and serum concentration of malonic dialdehyde (MDA). Based on the ACS type, all patients were divided into 3 main ACS groups, and then the groups were subdivided into subgroups based on the presence of DM2.

Results Development of ACS was associated with changes in WBC redox potential. These changes were characterized by a significant decrease in SDH activity in all ACS patients, irrespective of their ACS type, and a moderate decease in GR in patients with myocardial infarction compared to patients with unstable angina and healthy volunteers. At the same time, the SOD activity and MDA concentration were practically unchanged compared to the control group. There were practically no significant differences in the enzyme activities between the ACS subgroups with or without DM2.

Conclusion      The WBC activities of SDH and GR on day 1 of ACS can be considered as the indicators for early diagnosis of mitochondrial dysfunction resulting from the cardiovascular catastrophe as well as the markers for impaired primary cell defense. MDA and SOD values are not informative for determining the intensity of oxidative stress and further damage of the antioxidant system.
Immersive Digital Storytelling Learning Experience with a Metaverse Gamification Game Platform to Enhance Game Developer Competency
Authors:   Educational Research Development and Demonstration Institute, Srinakharinwirot University, Thailand, Karapakdee Jaruwan , Wannapiroon Panita
Published: June 2023

This paper presents research on an immersive digital storytelling learning experience with a metaverse gamification game platform to enhance game developer competency. The objectives were; 1) to develop an Immersive digital storytelling learning experience with a metaverse gamification; 2) to assess the game management architecture an Immersive digital storytelling learning experience with a metaverse gamification; 3) to assess a model for creating an immersive digital storytelling learning experience and; 4) to assess the game developer competency of students studying using an immersive digital storytelling learning experience with a metaverse gamification game platform. Research hypothesis is students using an Immersive digital storytelling learning experience with a metaverse gamification game platform and game development skills are perform at the highest level. The sample comprised 15 students at secondary school level 1 from Ongkharak Demonstration School, Srinakharinwirot University. Participants were recruited through multistage randomization. The research tool was a game developer assessment of learners using a realistic digital storytelling learning experience with a metaverse gamification gaming platform. The research results supporting the hypothesis were found to be at the highest level (mean = 4.97, S.D. = 0.18).
A Personality-Based Virtual Tutor for Adaptive Online Learning System
Authors:   School of IT, Mapua University, Manila, Philippines, Samonte Mary Jane , Acuña Gabriel Edrick O. , Alvarez Luis Antonio Z. , Miraflores Jeffrey M.
Published: June 2023

E-learning has become one of the most extensively used electronic systems in the field of education. Despite its benefits, there are some capabilities and concerns that may have a negative impact on students’ performance. As a result, personalized e-learning systems are being developed, which adapt e-learning systems to the users’ personality, knowledge, behavior, interests, or preferences. This will improve the overall learning experience and performance of the students. This study created and tested an e-learning system, called “Cybele” to help students learn cybersecurity in an online mode of learning. “Cybele” is a personality-based virtual instructor for cybersecurity online learning that includes a chatbot built using Rasa Open Source. The paper used Myers-Briggs Type Indicator (MBTI) personality model for initial learner assessment to address various student learning styles for a better online learning experience. Testing was done for the system functionality and the traditional learning approach was compared to the personalized e-learning system. Results show that students who participated in the developed adaptive e-learning environment performed better than those who pursue the traditional learning method.
Exploring the Research Trends of Technological Literacy Studies in Education: A Systematic Review Using Bibliometric Analysis
Authors:   the Department of Indonesia Language Education, Lampung University, Indonesia., Suyanto Edi , Fuad Muhammad , Antrakusuma Bayu , Suparman  , Shidiq Ari Syahidul
Published: June 2023

To date, the development of technological literacy studies representing the dynamics and phenomena of research regarding technological knowledge, technological capacity, and critical thinking-decision making has not been reported in scientific publications. Therefore, the purpose of this study is to present a bibliometric and bibliographic review regarding technological literacy studies. A bibliometric analysis was used to conduct this study in which 83 selected documents from the Scopus database published between 1991 and 2022 were the data. Some analyses, such as performance, citation, co-word, and co-authorship, were carried out to analyze the data supported by VOSviewer and PoP software. Results of this study revealed that the number of studies regarding technological literacy increased gradually, while the progress citations on the studies of technological literacy were not consistent every year. In addition, the most productive and influential documents, authors, countries, institutions, and sources contributed to developing technological literacy research. Furthermore, autonomous technology is expected to be the newly trending research in the technology field. Consequently, the studies about autonomous technology can be directed to further educational studies focusing on technology education. The development of autonomous technology in the future, like a robot for teaching, contributes to educational advancement.
The Design and Development of an Academic-Result Transfer System: A Case Study in Thailand
Authors:   the Faculty of Business Administration, Rajamangala University of Technology Isan, Thailand, Vaenthaisong Prachasan , Kitwatthanathawon Phichayasini
Published: June 2023

This research aimed to design and develop an academic-result transfer system for the Faculty of Business Administration, Rajamangala University of Technology Isan, Thailand. The objectives of this research were to increase the efficiency and save time in academic-result transfer process. The proposed system could operate online as a web application. There are seven majors of the Faculty of Business Administration that put this system into practice with the students in the credit transfer program during 2020–2021 academic years. The proposed system saved a lot of time and helped make the academic-result transfer work more conveniently and quickly. Moreover, the results of academic-result transfer were accurate. The concepts put forth by Jacob Nielsen were applied in users’ satisfaction evaluation. The students, staffs, and instructors of all seven ajors who were responsi le for acade ic-results transfer gave the overall satisfaction scores of the proposed syste at a very good level x = 4.35, S.D. = 0.52). In addition, this research was registered as the intellectual property in literary works.
Philosophy is reflective…or not?
Authors: Smirnov Andrey V.
Published: June 2023

The article focuses on the historical background for a logic-and-meaning approach to consciousness as tselostnost’. This notion, having no equivalent in English, may roughly be rendered as "a (self)developing whole". The author demonstrates that in the thought experiment "soaring man" Ibn Sina discovers the pure self as an unavoidable condition of our consciousness. This self is revealed to itself in a different way, in a different cognitive act than any object of knowledge. Then Descartes’ discovery of the ‘S is P’ predication formula as a condition for multiplicity of our phenomenal ego is discussed. The line can be traced back to Nicolas of Cusa, who discovered development and envelopment, and continued to a contemporary French sinologist Francois Jullien, who argues that, paradoxically, the ultimate foundations of any philosophical tradition cannot be clarified and reflected upon by means of that very tradition.
The concepts of apperception and reflection in Kant and the concept of reflection in Husserl
Authors: Orlova Yulia
Published: June 2023

The article considers reflection as a method and condition of the transcendental philosophy of Kant and Husserl. At the beginning, the author refers to Kant's predecessors who used the term reflection (Wolf, Baumgartner) and concludes that Kant, when referring to reflection, rather adheres to the tradition laid down by Leibniz. Based on the text of the “Critique of Pure Reason”, the article argues that it is with the help of reflection that the formation of a priori categories and a priori synthetic principles can be explained. The author distinguishes between reflection and the transcendental unity of apperception and examines, within the framework of the phenomenological interpretation of the “Critique of Pure Reason”, the role of this unity in the predilection of sensory diversity. The article shows the continuity in the understanding of reflection between transcendental phenomenology and Kant's philosophy. In Husserl's philosophy, reflection as a method is associated with reduction and contemplation. The author dwells on the features of the use of reflection in Husserl's studies, which include, first of all, the temporal language of description and the dependence of reflection on the phenomena to which it is directed.
Orlova Yulia Olegovna (1970 2011) – is a Russian philosopher, Ph.D., in 1998 - 2011 worked at the Department of Ontology and Theory of Cognition of the Faculty of Philosophy of St. Petersburg State University.
DESIGN AND EVALUATION OF AN IOTA-BASED MEDICAL INFORMATION SYSTEM
Authors: Shmatko Oleksandr , Kliuchka Yaroslav , Korolov Roman , Khvostenko Vladyslav , Dunaiev Sergii
Published: June 2023

The traditional medical information systems are plagued by issues such as data breaches, lack of privacy, and data integrity concerns. This paper presents the design and evaluation of an IOTA-based medical information system aimed at addressing these challenges. In recent years, blockchain technology has emerged as a powerful tool for securing and managing data in a decentralized manner. One area where this technology has the potential to revolutionize the way we do things is in e-medicine. E-medicine, or electronic medicine, refers to the use of technology to deliver healthcare services remotely. This includes telemedicine, online consultations, and remote monitoring of patients' health status. IOTA blockchain technology, in particular, has a lot of potential in e-medicine. IOTA is a distributed ledger technology that uses a directed acyclic graph (DAG) instead of a traditional blockchain. The main ad-vantage of this approach is that it eliminates the need for miners and makes the system more scalable, fast, and energy-efficient. IOTA is also designed to be feeless, making it an ideal choice for microtransactions. In e-medicine, IOTA can be used in several ways. One potential use case is for secure and decentralized storage of patients' medical records. Medical records are highly sensitive and contain confidential information that needs to be protected from unauthorized access. By using IOTA's tamper-proof and immutable ledger, patients can have more control over their medical records and choose who has access to them. This can be especially useful in situations where patients need to share their medical records with multiple healthcare providers or research institutions. By leveraging the unique features of IOTA, such as its feeless microtransactions, scalability, and distributed ledger technology, the proposed system enhances security, privacy, and interoperability in healthcare information management. The evaluation of the system involves performance tests, and a comparison with existing solutions.
Edoxaban therapy in non-valvular atrial fibrillation patients: Paradoxical effect on mean platelet volume
Authors: ERBAY İlke , AKER Mert , SÜNER Ahmet Furkan , AKIN Yeşim , ÖNALAN Orhan
Published: June 2023

Introduction: New generation oral anticoagulants (NOACs), which selectively and reversibly block the activity of clotting factor Xa, are now preferred as first-line therapy for preventing ischemic stroke in the treatment of atrial fibrillation (AF). Edoxaban, one of these NOACs, has been shown to be as effective as warfarin in preventing stroke or systemic embolism, while carrying a lower risk of bleeding and cardiovascular death. Mean platelet volume (MPV), as an indicator of platelet activity, is associated with an increased risk of ischemic stroke in patients with AF. Therefore, medical therapies that reduce MPV may play an important role in preventing unwanted ischemic events.

Objective: The aim of this study is to determine whether edoxaban has an effect on platelet volume and other platelet indices, in addition to its protective anticoagulant effect against ischemic stroke.

Materials and Methods: The study was designed as a retrospective cross-sectional study. Two hundred non-valvular AF patients without a history of oral anticoagulant use were included in the study. Complete blood count (CBC) and basic biochemical parameters (urea, creatinine, electrolytes, etc.) were recorded from the hospital registration system before edoxaban treatment was started, along with basic demographic data. The CBCs of the patients were reevaluated an average of 6 months (184 ± 9 days) after edoxaban treatment initiation, and platelet indices after edoxaban treatment were compared. Results were presented as mean ± standard deviation and percentage. Data were compared using Student's t-test and Wilcoxon test, and p
Correction of posterior mitral leaflet prolapse with Fundaro annuloplasty: Can suture annuloplasty techniques be helpful for surgeon?
Authors: MOLA Serkan , GÜNERTEM Eren , ÇİÇEK Ömer Faruk , YAŞAR Emre , ERKENGEL Halil İbrahim , LAFÇI Gökhan
Published: June 2023

Aim

Fundaro annuloplasty is a posterior leaflet repair technique developed for asymmetric tethering of mitral leaflets due to inferior myocardial infarction. ". In our study, we aimed to share our the operative and mid-term results of the fundaro annuloplasty technique.

Material and Methods

30 patients who underwent Fundaro annuloplasty for type 3b mitral regurgitation were included in the study. Fundaro annuloplasty with CABG was performed in 20 patients from this patient group, the remaining 10 patients underwent combined procedures. During the flollow-ups of the patients, physical examination, electrocardiography and transthoracic echocardiography were performed.

Results

The mean follow-up period of the patients included in the study was 35.8±20.3 months (min:1 max:59). According to the TEE datas performed intraoperatively, MR was not detected in 24 (80%) patients. The mean postoperative follow-up period of the patients was 35.8±20.3 months. During the follow-up period, recurrent MR was not observed in 23 (76.7%) patients. Mortality developed in 2 (6.7%) patients in the early postoperative period. Significant improvement was observed in their functional capacities(p
Optimization of Pre-treatment Incubation Period on Callus Induction Response in Anthers of Selected Rice Genotypes
Authors: Sharmela P. , Ganesan N. Meenakshi , Saraswathi R. , Gnanam R. , Chandrasekhar C.N.
Published: June 2023

Background: The microspores of five tropical japonica and five indica rice genotypes were subjected to androgenic studies. The effect of growth regulators on callus induction were studied to improve the anther culture efficiency. Methods: The cold pre-treatment of panicles at 10°C were done at different days of intervals viz., 5, 8, 10 and 12 days. The microspores at uninucleate stage were selected and dusted after pre-treatment. The anthers were cultured in N6 basal media supplemented with casein hydrolysate (250 mg/L), proline (250 mg/L), silver nitrate (100 mg/L), maltose (50 g/L) and growth regulators. Result: The 8 days of cold pre-treatment initiated calli in most of the ten genotypes. The days taken for callus induction varied with genotype from 32-55 days. The callus induction frequency ranged from 1.41 to 5.12%. The responsive genotypes (Azucena, Palawan, Nira) on callus induction were studied for their regeneration potential. Background: The microspores of five tropical japonica and five indica rice genotypes were subjected to androgenic studies. The effect of growth regulators on callus induction were studied to improve the anther culture efficiency.
Optimizing Analytical Methods to Determine Lycopene Levels in Syrian Tomatoes from Various Regions
Authors: Alnokkari Afraa Samir
Published: June 2023

Background: The particular attention in recent years on high nutritional quality food is increasing because of its health benefits. Tomato, which a common fruit in different regions of Syria, is one of these foods. It contains plentiful antioxidant compounds, including lycopene. Lycopene plays a very significant role in human health and nutrition; it is considered a strong antioxidant due to its ability to trap singlet oxygen and remove the peroxyl radical. This study aims to quantify of lycopene content of fresh tomatoes in Syria and determine the best analytical method (solvent for separation by HPLC) for separation by HPLC. Methods: Tomatoes from different Syrian regions were quantitatively analyzed for the detection of lycopene, using reversed-phase high performance liquid chromatography through isocratic elution and UV detection. Many mobile phases were under experiments in order to maximum achievement the lycopene separation. Result: An Analytical method for determination of lycopene in Syrian tomato samples was optimized and the proper solvent for separation and determination of lycopene in Syrian tomato samples was (MeOH/propanol/THF) (15:65:20). The lycopene content in Syrian tomatoes ranged from 55.94 to 103.70 ìg/g, this disparity was attributed to many genetic and environmental factors. This study suggests that Syrian tomato is rich source of lycopene and a major provenance of this powerful antioxidant and can be considered as a possible alternative to antioxidative supplements.
Qualitative and Quantitative Traits Associate Genetic Variability of Soybean (Glycine max) Mutants for Expedited Varietal Improvement Program
Authors: Alam Md. Amirul , Bhuiyan M.S.H. , Malek M.A. , Emon R.M. , Khatun Khadija , Kobir Humayun
Published: June 2023

Background: Soybean is an excellent source of protein, also richer in oil than most legumes, making them a good source for vegetable oil and biofuels. Among various difficulties the maturity period of existing soybean varieties is the main hindrance of utilizing this for the existing cropping system. The narrow genetic base of cultivated soybean varieties and germplasm limit the scope to utilize directly in the breeding program. Methods: Mutation breeding is one of the techniques that provide large genetic diversity from a single source. To broaden the genetic diversity Binasoybean-3 and Binasoybean-4 were imposed to different doses of gamma radiation. The mutants were selected based on their agronomic performance and grouped at five different clusters at M5 generations. Maximum selection pressure was done during maturity period with protein and oil content. Result: Finally, eight mutants were selected for the advance breeding program, whereas mutants SM-03-15-5 mature within 90 days, containing 38% protein and 18.4% oil content will be considered directly for further steps of varietal release system. Background: Soybean is an excellent source of protein, also richer in oil than most legumes, making them a good source for vegetable oil and biofuels. Among various difficulties the maturity period of existing soybean varieties is the main hindrance of utilizing this for the existing cropping system. The narrow genetic base of cultivated soybean varieties and germplasm limit the scope to utilize directly in the breeding program.
تعزيز مراقبة المعلومات الصحية:تطبيق المراقبة المجتمعية في السودان
Authors: Sharif Mariam , Ahmed Rasha , Duclos Diane , Palmer Jennifer
Published: June 2023

راسة الحالة هذه تدرس تنفيذ برنامج مراقبة مجتمعية في السودان في الفترة 2018-2022. وتم تصميم البرنامج لتلبية الاحتياجات الحرجة لنظام المراقبة الصحي الحالي. كما تهدف إلى تمكين المجتمعات من كشف واحتواء تهديدات الصحة العامة، وإلى تحسين العلاقات بين المجتمعات وأنظمة الصحة المحلية، وإلى اشراك القرى في المناطق الريفية. وحضر موظفون على المستوىالفدرالي والولاية والمنطقة ورشات عمل خاصة بالمراقبة المجتمعية قبلتجنيد وتدريب المتطوعين المجتمعيين. وتم تجنيد أكثر من 8000 متطوع في 11 ولاية. وقام المتطوعون بلفت نظر الموظفين إلى متلازمات ذات أولوية لأمراض معدية، بالإضافة إلى حوادث محلية ذات توابع على الصحة العامة (مثل: الكوارث الطبيعية، والنزوح الناجم عن الصراعات، وانعدام الأمن الغذائي). ويمكناستخدام الدروس المستفادة لزيادة الفهم حول برامج المراقبة المجتمعية واسعة النطاق، ولتحديد فرص تعزيز برامج جديدة وأخرى قائمة. ولمزيد من إرشادات العلوم الاجتماعية حول المراقبة المجتمعية، الرجاء الاطلاع على الدراسة الشريكة: اعتبارات أساسية: المراقبة المجتمعية في الصحة العامة
Relationship Between Trunk and Lower Extremity Muscles and Balance in Multiple Sclerosis Patients
Authors: ERDEO Fatma , UCA Ali Ulvi , YILMAZ Neslihan Altuntas , DOĞAN Ahmet Furkan , ŞİMŞEK Ahmet
Published: June 2023

Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease that causes demyelination of nerve fibers. This neurological process causes physical and mental changes in and to the motor, sensory, and cognitive systems. This study aims to determine the relationship between balance and muscle strength in people with multiple sclerosis. This study included 36 MS patients’ ⩾18 years old who were treated and followed up according to routine clinical practice at a university hospital in Türkiye, which were observational, non-invasive, and a control group of 32 patients whose relatives were voluntarily evaluated without any neurological problems. Muscle strength was measured manually. In balance analysis, computerized balance analysis system was used. The mean age of the MS group was 46.14 (SD±7.14) and the mean age of the healthy group (HG) was 42.25 (SD±10.81). While muscles of abdominal, hamstring, hip flexor and extensor, tibialis anterior and tibialis posterior muscle strength were found to be positively significant with balance in the MS group, P0.05). This study revealed significant correlations between balance and strength parameters of trunk and lower extremity muscles. Our study suggests that rehabilitation protocols for MS patients should include a critical strength training program, especially for trunk and lower extremity muscles.
Mültecilerin Geri Dönüşü ve Birleşmiş Milletler Mülteciler Yüksek Komiserliği
Authors: ÖZDEMİR Durdu Mehmet , KANTAR Gökmen
Published: June 2023

Mültecilik olgusu, özellikle soğuk savaş sonrası dönemde devletler tarafından güvenlikleştirilmeye başlayan bir olgu olarak uluslararası gündemdeki ana konulardan birisi olmaya başlamıştır. Bu durum karşısında, mültecilik olgusunun; ulusal, bölgesel ve küresel anlamda ortaya çıkardığı risk ve tehditlerin ortadan kaldırılması ya da en aza indirilmesi amacıyla uluslararası sistemdeki temel aktörler tarafından çeşitli politikalar hayata geçirilmeye çalışılmıştır. Bu anlamda Birleşmiş Milletler Mülteciler Yüksek Komiserliği (BMMYK) bu alanda çalışma yürüten en etkili aktörlerden biri olarak ön plana çıkmıştır. BMMYK özellikle geri dönüşlerin sağlanması ve nasıl olması gerektiği noktasında önemli politik yaklaşımlar üreterek sorunun çözümüne katkı sağlamaya ve belirli standart uygulamalar ortaya koymaya çalışmıştır. Bu çalışmada mültecilerin geri dönüşlerinin ne anlama geldiği, bu geri dönüşlerin nasıl olması gerektiği, geri dönüşleri etkileyen faktörlerin neler olduğu ve BMMYK’nın bu süreçlerde ne gibi roller üstlendiğine ilişkin sorulara cevap aranmıştır.
Arquivamento da Web
Authors: Boeres Sonia Araújo de Assis , Saad Rondineli Gama
Published: June 2023

Introdução: A importância do arquivamento web está em preservar e dar acesso, em longo prazo, às informações digitais publicadas na internet. Com a crescente quantidade de conteúdo digital, há um risco real de que informações valiosas sejam perdidas, corrompidas ou tornem-se inacessíveis, devido às mudanças tecnológicas, atualizações de plataformas, ou até mesmo exclusões acidentais ou intencionais. O arquivamento da web é fundamental para a preservação digital e para o acesso contínuo das informações institucionais, garantindo a disponibilidade, confiabilidade e continuidade do patrimônio digital da sociedade, e para o avanço da pesquisa, educação, transparência e preservação da história digital. Objetivo: Apresentar o tema, definindo arquivamento web, mostrando como o processo é feito, as estratégias, os fluxos, e as iniciativas internacionais e nacionais, entre elas, o projeto ARQUIWEB, do Instituto Brasileiro de Informação em Ciência e Tecnologia (IBICT) e da Rede Cariniana. Metodologia: Pesquisa exploratória descritiva, utilizando o repositório de dados E-LIS e outras fontes, por meio da expressão iniciativas e estratégias para o arquivamento da web, em português e inglês. Resultados: Foram apresentadas sete iniciativas internacionais em variados contextos (bibliotecas e arquivos nacionais, organizações governamentais e sem fins lucrativos), e duas nacionais, onde pode-se destacar, o ARQUIWEB, que arquivará sítios de instituições parceiras e governamentais. Conclusão: Ainda são incipientes as iniciativas nacionais de arquivamento web, comparadas às internacionais, o que mostra possibilidades de estudo e a importância de estabelecer políticas, ter estratégias, e seguir fluxos para o arquivamento web nas instituições, garantindo qualidade na coleta e no resultado.
Preservação digital da informação científica
Authors: Rungo Alírio Alcâncer , Madio Telma Campanha de Carvalho , Grácio José Carlos Abud
Published: June 2023

Introdução: Com a crescente importância dos recursos digitais na democratização da informação científica e as fragilidades desses recursos torna-se crucial garantir a preservação da informação científica em formato digital. Isso garantirá que os bens culturais e testemunhos da memória científica sejam transmitidos para as futuras gerações e que os processos de produção de conhecimento e inovação científicas sejam preservados. Objetivo: Este estudo tem como objetivo realizar uma análise bibliométrica quali-quantitativa do cenário da produção científica internacional sobre a preservação digital da informação científica, utilizando a aplicação Mendeley da Elsevier. O estudo é exploratório e descritivo e visa entender o comportamento da produção da literatura nos últimos 10 anos (de 2012 a 2022) em torno da preservação digital da informação científica.  Metodologia: Foram coletados dados através da aplicação Mendeley, onde foram recuperadas um total de 904 publicações. Com base na aplicação do Protocolo de Revisão Bibliométrica, foram selecionadas 94 publicações, que constituíram o conjunto de textos de análise do estudo. A análise dessas publicações foi baseada em cinco categorias, utilizando os seguintes indicadores bibliométricos: periódico científico, publicações, ano de publicação, buscas/acessos, autoria e conteúdo abordado. Resultados: A análise revelou um aumento na produção científica em torno da preservação digital da informação científica nos últimos cinco anos, com uma tendência de abordar questões emergentes deste campo, como repositórios científicos, repositórios de dados, uso de metadados, serviços de nuvem, descrição e representação de dados e informações. Conclusão: Conclui-se que há a necessidade de aprofundamento dos estudos dessas temáticas, assim como a realização de revisões sistemáticas da literatura para aprofundar as discussões específicas tratadas por esses estudos.
Plano de gestão de dados de pesquisa de povos indígenas
Authors: Torino Emanuelle , Monteiro Elizabete Cristina de Souza de Aguiar , Vidotti Silvana Aparecida Borsetti Gregorio
Published: June 2023

Introdução: A gestão de dados de pesquisa é uma preocupação recente da comunidade científica. Pesquisadores e grupos de pesquisa têm diferentes práticas e abordagens de gestão de dados, considerando aspectos relacionados às suas áreas de conhecimento. Nesse contexto, o tratamento dos dados, desde a fase de coleta até a disponibilização, deve considerar aspectos como os Princípios FAIR e CARE, bem como à preservação digital, questões fundamentais para assegurar que os dados gerados possam ser compartilhados para acesso e uso atual e futuro. Objetivo: Discutir o Plano de Gestão de Dados de Pesquisa de Povos Indígenas, trazendo aos seus elementos os Princípios FAIR e CARE, bem como aspectos relacionados à preservação digital. Metodologia: Pesquisa bibliográfica e exploratória com abordagem qualitativa, aplicável ao contexto do Plano de Gestão de Dados de Pesquisa, em especial de Povos Indígenas. Resultados: É apresentado um arcabouço teórico que instrumentaliza o pesquisador para a elaboração do Plano de Gestão de Dados de Pesquisa de Povos Indígenas, considerando o tratamento ético, técnico e a preservação digital dos dados. Conclusão: A pesquisa auxilia os pesquisadores na compreensão dos Princípios FAIR e CARE, bem como nas ações de preservação digital a serem desenvolvidas para possibilitar localizar, acessar e (re)utilizar os dados criados, compilados ou gerados no futuro. Dessa forma, o pesquisador poderá elaborar o Plano de Gestão de Dados de Pesquisa de Povos Indígenas em atendimento aos Princípios FAIR e CARE e à preservação digital.
CHARACTERISTICS OF STYROFOAM WASTE-BASED MEMBRANE THROUGH VAPOR AND LIQUID-INDUCED PHASE INVERSION PROCESS
Authors: Nurherdiana Silvana Dwi , Wahyudi Bambang , Stefanny Merry Jhoe , Karlina Anita , Yogaswara Rachmad Ramadhan , Jalil Mohd Jumain , Fansuri Hamzah
Published: June 2023

Polymeric membrane-based-Styrofoam waste in the form of a thin sheet was successfully prepared by a phase-inversion technique in different final solidification treatments, namely, immersion and evaporation. This study aims to identify the effects of different solidification processes on membrane properties such as hydrophobicity, pore configuration, porosity, and membrane temperature stability. Characterization was carried out using contact angle, SEM, FTIR, TGA, and porosity tests. The results showed that an increase in Styrofoam 18-30 wt.% in dimethylformamide (DMF) as solvent decreases the hydrophobicity by 9.5%. The average contact angle of 62–80° indicated that the obtained membrane was prepared by immersion treatment. The membrane subjected to evaporation treatment was hydrophobic. Moreover, the microscopy image shows that the immersed membrane was denser than the evaporated membrane. This showed that a higher exchange rate between the solvent and non-solvent (water) produced a tight membrane than free evaporation in air. The polystyrene membrane from Styrofoam exhibited excellent temperature stability up to 350 °C. In addition, the mechanical strength was affected by employing different solidification processes. The obtained results were also successfully tabulated from a statistical point of view to validate the conclusions. The following information can provide basic knowledge for modifying membrane-based-Styrofoam to optimize zero-waste goals.
SCREENING OF PIROXICAM SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) USING FRACTIONAL FACTORIAL DESIGN
Authors: Septiawan Adi Nugroho  , Kuncahyo Ilham , Marlina Dian
Published: June 2023

Piroxicam belongs to BCS class II and has low solubility. Self-nanoemulsifying drug delivery systems (SNEDDS) are considered a potential approach for increasing the solubility and release of piroxicam. This study aimed to select the components and component ratios of piroxicam SNEDDS using fractional factorial design 26-2 (FFD). The variables used in the DFT development of piroxicam SNEDDS are the type and concentration of oil (triacetin and oleic acid), surfactant (kolliphor EL and Tween 60), and co-surfactants (Transcutol and PEG 400). The FFD results showed 16 runs with different proportions of the piroxicam SNEDDS components, which were then characterized by critical parameters including emulsification time, %transmittance, droplet size, and drug loading. The components and component ratios of the PKM SNEDDS were determined using single-factor plot analysis. The results showed that triacetin (oil), kolliphor EL (surfactant), Transcutol (co-surfactant) had the greatest contribution to the formation of piroxicam SNEDDS with an oil ratio range of 11.11–28.57%, surfactant 44.44–77.78%, co-surfactant 11.11–44.44 %.
EFFECT OF AMMONIA-ETHANOL MOLE RATIO ON THE SILICA NANOPARTICLES SYNTHESIZED FOR RHODAMINE B DYES ADSORPTION
Authors: Yayuk Puji Lestari  , Amaria Amaria
Published: June 2023

Various ammonia-ethanol mole ratios were successfully used for the synthesis of silica nanoparticles for rhodamine B adsorption. This study aims to determine the characteristics of the adsorbent at different ammonia-ethanol mole ratios, maximum adsorption at pH, and contact time. Several steps, including extraction of Na2SiO3 from rice husk ash, synthesis of adsorbents with ammonia-ethanol mole ratios (14:1, 21:1, 28:1, and 42:1), and their characterization. The parameters studied in the adsorbent include the functional groups, particle size, maximum pH, and rate constant adsorption. The FTIR results showed that all adsorbents had functional groups, indicating the presence of silica. The results suggest that the optimum mole ratio of NS 14:1 particles has a size of 39.82 nm. The optimum adsorption of rhodamine B by NS 14:1 occurred at a pH 3 of 0.00419 mmol.g-1 and a contact time of 40 min. The rate constant of adsorption by NS 14:1 was 102.42 g.mmol-1.min-1 followed a pseudo-second order kinetic model.
Pathological Characteristics of Fiberoptic Bronchoscopy Procedure in Ulin General Hospital, Banjarmasin
Authors: Nurrasyidah Ira , Nuzula Muhammad Ajib , Oktaviyanti Ika Kustiyah , Rahmawaty Desi , Wanahari Tenri Ashari
Published: June 2023

Introduction:  Fiberoptic Bronchoscopy (FOB) has emerged into the method of choice for the detection of lung tumors due to its availability of Adequate cytological and histological samples in the form of broncho-alveolar lavage, bronchial brushings, and bronchial forceps biopsy. This study aims to identify characteristics of bronchoalveolar lavage, aspiration cytology, brushing cytology and forceps cytology of patients suspected with malignancy at the Ulin Regional Hospital in South Kalimantan.
Methods: A cross-sectional study was carried out utilizing medical documentation of patients suspested lung cancer from March 2018 to March 2020. Data were grouped by gender, age, type of procedure, and cytology and histopathology findings.
Results: The result showed that 67.5% of 117 patients who underwent bronchoscopy had positive results and common histological diagnosis The frequent histopathological conclusion was adenocarcinoma (45.6%) tailed by squamous cell carcinoma (40.55). Forceps bronchoscopy showed a greater positivity rate (75.0%) than bronchoscopy without forceps (63.6%), we also found that by combining BAL and brushing and forceps biopsy, the detection rate of lung malignancy increased to 85.7%, but no correlation between the type of procedure and the likelihood of malignancy was discovered.
Conclusions: Forceps bronchoscopy showed a greater positivity rate than bronchoscopy without forceps, but no correlation between the type of procedure and the likelihood of malignancy was discovered in our study.
Is Docetaxel the Main Therapy for Lung Metastasis in Granular Cell Tumors?
Authors: Pramono Heru Sigit , Setijadi Ana Rima , Sutanto Yusup Subagio , Wasita Brian
Published: June 2023

Introduction: A granular cell tumor is a rare neoplasm originating from mesenchymal tissue. Malignant granular cell tumors have a poor prognosis. The lung is one of the target organs for metastatic malignant granular cell tumors. The number of rare cases makes managing metastatic malignant granular cell tumors unknown.
Case: A 19-year-old male complained of shortness of breath for two months. A liver nodule biopsy revealed poorly differentiated carcinoma metastases. Histopathology of the left manus and frontal masses found granular cell tumors—negative immunohistochemistry on S-100 and myogenin. Ki-67 obtained a value of 5%. An X-ray and contrast multislice computerized tomography (MSCT) scan showed multiple metastatic nodules. Right bronchial biopsy forceps revealed a metastatic granular cell tumor. The patient was given docetaxel for six cycles. During the post-administration of docetaxel, the patient experienced clinical and radiological improvement.
Conclusion: Until 2016, only three case reports of S-100 negative granular cell tumors existed. A negative S-100 test does not rule out the diagnosis of granular cell tumors. Malignant lesions are more common in males, as in this case. The number of rare cases means that management cannot be determined. Reports of similar cases show patients surviving up to 11 years with docetaxel administration. The patient in this study has survived for one year and is complaint-free.
Diagnostic Approach of Lung Cancer: A Literature Review
Authors: Hana Jesi , Faizah Novia Nurul
Published: June 2023

Lung cancer is the second most commonly diagnosed malignancy with the highest mortality rate. It can be classified into small-cell lung carcinoma (SCLC) and non-small-cell lung carcinoma (NSCLC). At the early stage of the disease, lung cancer rarely gives apparent symptoms. Patients are usually diagnosed at an advanced stage. Lung cancer is closely related to tobacco smoking. The increasing prevalence of tobacco smoking in Indonesia should be an alarm. During the last decades, knowledge and technology regarding lung cancer screening and diagnosis have vastly increased. Proper screening for high-risk individuals will help to increase the survival rate from the disease. Diagnosis of lung cancer using various radiologic modalities, histopathology, and biomolecular tests will also determine a specific treatment approach for the patient. A proper diagnostic test will also help predict the patient’s prognosis. This literature review aimed to provide foundation knowledge from recent guidelines for screening and diagnosing lung cancer.
Current Developments of Smoking and Vaping, Is Vaping Safer?
Authors: Simanjuntak Arya Marganda , Hutapea Anastasya , Tampubolon Bryan Steffanus , Browlim Stephani , Napitupulu Yosep Pebriyanto , Siregar Indi Esha , Suyanto Suyanto
Published: June 2023

Vape fans claim that vaping is the solution of smoking cessation, but this is still debatable. Even if vape is still considered new, numerous studies show   vaping is associated with lung injury (EVALI). Despite this, the trend of vaping is  still increasing. This study aims to review current understanding of conventional smoking and vaping and comparing both. Is vaping safer than smoking? Smoking has health risk for lung cancer, COPD, stroke, and others meanwhile vaping has been linked with lung injury (EVALI). Local perfusions were decreased in tobacco smokers after exposure. However, perfusion increased in vaping after exposure. Bronchoalveolar lavage in vape users showed increase of vitamin E acetate possibly causing impairment in lung structure and functionality of surfactant. This is the potential mechanism of EVALI in vape users. Smoking uses the Brinkman Index to determine severity of smoking but there’s no index for vaping because it depends not on how many sticks but how many e-liquids were used. It seems that vape is “safer” rather than smoking but between smoking and vaping both have their own risk in health aspects and it’s safe to assume that neither is safe for   use. “Vape is the solution for smoking cessation” needs further research because researchers need years to understand conventional smoking in relation with other diseases. Prospective follow-up studies to determine the risk of vaping on other diseases are needed in the future.