bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of time-varying recurrence patterns in breast cancer patients with different molecular subtypes treated from 2008 to 2012 and from 2013 to 2016: a single-center retrospective study
Authors: Zhou Xu-jie , Sang Yu-ting , Chen Jia-jian , Mo Miao , Hou Jian-jing , Yang Ben-long , Wu Jiong
Published: June 2022

Purpose: To compare the time-varying recurrence patterns of different molecular subtypes of breast cancer in the contemporary era with those in the past era. Methods: This retrospective study included 14627 consecutive invasive breast cancer patients who underwent surgery from 2008 to 2016 at Fudan University Shanghai Cancer Center. We defined the period from 2013 to 2016 as the contemporary era and that from 2008 to 2012 as the past era. Five subtypes were defined according to the immunohistochemistry results. Emphasis was made on the changing patterns of recurrence for patients with different molecular subtypes changed between the two treatment eras. Kaplan–Meier survival curves were generated, and the hazard function was used to estimate the annual recurrence hazard. Results: By the end of follow-up (median, 68.1 months), 1429 patients (9.77%) experienced recurrence and metastasis. The annual recurrence risks of the entire population and each molecular type in 2013-2016 were reduced compared with those in 2008-2012. Luminal A and triple-negative patients in 2013-2016 showed a significantly lower recurrence hazard curve than those in 2008-2012. The recurrence hazard curve of luminal B (HER2-) and HER2+ subtypes was lower in 2013-2016 than in 2008-2012. The recurrence risk of the luminal B (HER2+) subtype was reduced substantially during 2013-2016, showing a delay of two years.Conclusion: With early detection of disease recurrence and improved treatment strategies, the recurrence patterns of different molecular subtypes of breast cancer have changed. The time-varying recurrence patterns observed during the contemporary era are significant for treatment decision-making and clinical trial planning.
3D printing of cellulose nanocrystals based composites to build robust biomimetic scaffolds for bone tissue engineering
Authors: N’Gatta Kanga Marius , Belaid Habib , Assanvo Edja Florentin , Kajdan Marilyn , Masquelez Nathalie , Boa David , Cavaillès Vincent , Bechelany Mikhael , Salameh Chrystelle
Published: June 2022

Cellulose nanocrystals (CNC) are drawing increasing attention in the fields of biomedicine and healthcare owing to their durability, biocompatibility, biodegradability and excellent mechanical properties. Herein, we fabricated using fused deposition modelling (FDM) technology 3D composite scaffolds from polylactic acid (PLA) and CNC extracted from Ficus thonningii (FT). Scanning electron microscopy revealed that the printed scaffolds exhibit interconnected pores with an estimated average pore size of approximately 400 µm. Incorporating 3% (w/w) of CNC into the composite improved PLA mechanical properties (Young's modulus increased by ~ 30%) and wettability (water contact angle decreased by ~ 17%). The mineralization process of printed scaffolds using simulated body fluid was validated and nucleation of hydroxyapatite confirmed. Additionally, cytocompatibility tests revealed that PLA and PLA/CNC scaffolds are non-toxic and compatible with bone cells. Our design, based on rapid 3D printing of PLA/CNC composites, combines the ability to control the architecture and provide improved mechanical and biological properties of the scaffolds, which opens perspectives for applications in bone tissue engineering and in regenerative medicine.
Effect of age and prior COVID-19 on BBIBP-CorV (Sinopharm) vaccination- induced antibody responses in a region with high seroprevalence
Authors: Hasan Zahra , Masood Kiran Iqbal , Qaiser Shama , Khan Erum , Hussain Areeba , Ghous Zara , Khan Unab , Hassan Imran , Yameen Maliha , Memon Haris Ali , Ali Shiza , Balouch Sadaf , Nasir Muhammad Imran , Qazi Muhammad Farrukh , Veldhoen Marc , Simas J Pedro , Bhutta Zulfiqar A , Mahmood Syed Faisal , Hussain Rabia , Ghias Kulsoom
Published: June 2022

Introduction
Sinopharm (BBIBP-CorV) inactivated virus vaccination for COVID-19 has been administered widely in Pakistan. We investigated the dynamics of BBIBP-CorV -induced antibody responses over a 24 week period in a region with a high seroprevalence.
Methods
Study subjects (n = 312) were followed up over a 24-week period between May and August 2021. Sera were tested for IgG antibodies to spike and the receptor binding domain (RBD).
Results
Study subjects were 62% female. Twenty-two percent had a prior history of COVID-19. At 4-, 8- 16- and 24-weeks post-vaccination, the rate of IgG antibodies positive to spike was 57%, 87%, 66% and 90% of individuals, compared with to RBD which was 48%, 62%, 68% and 85% of subjects, respectively,. IgG to spike and RBD showed a positive correlation at each interval (rho > 0.6, p < 0.0001). Seropositivity to both spike and RBD was reduced in those aged 50 years and over for up until 16 weeks post-vaccination (p < 0.05). Individuals with prior COVID-19 infection showed greater antibody responses for up to 16 weeks post-vaccination (p < 0.05). SARS-CoV-2 infections were observed with a mean interval of 16 weeks post-vaccination. Antibody responses did not wane for up to 6 months post-vaccination.
Conclusions
Sinopharm vaccination-induced antibody responses were negatively impacted by age and positively impacted by prior COVID-19 for 16 weeks after vaccination. Importantly, we did not find waning of IgG antibodies to RBD over the study period. Maintenance of antibodies may be the result of continued community exposure and boosting with COVID-19 vaccination.
Early prediction of prostate cancer risk in younger men using polygenic risk scores and electronic health records
Authors: Varma Amita , Maharjan Jenish , Garikipati Anurag , Hurtado Myrna , Shokouhi Sepideh , Mao Qingqing
Published: June 2022

Background
Prostate cancer (PCa) screening is not routinely conducted in men 55 and younger, although this age group accounts for more than 10% of cases. Polygenic risk scores (PRSs) and patient data applied towards early prediction of PCa may lead to earlier interventions and increased survival. We have developed machine learning models to predict PCa risk in men 55 and under using PRSs combined with patient data.
Methods
We conducted a retrospective study on 91,106 male patients aged 35 to 55 using the UK Biobank database. Five gradient boosting models were developed and validated utilizing routine screening data, PRSs, additional clinical data, or combinations of the three.
Results
Combinations of PRSs and patient data outperformed models that utilized PRS or patient data only, and the highest performing models achieved an area under the receiver operating characteristic curve of 0.788. Our models demonstrated a substantially lower false positive rate (35.4%) in comparison to standard screening using prostate specific antigen (60–67%).
Conclusion
This study provides the first preliminary evidence for the use of PRSs with patient data in a machine learning algorithm for PCa risk prediction in men 55 and under for whom screening is not standard practice.
Effect of Atriplex halimus extract as a biostimulant on physiological and biochemical regulation in faba bean plants.
Authors: ENNOURY Abdelhamid , roussi zoulfa , nhhala Nada , zouaoui Zakia , kabach Imad , Krid Azzouz , kchikich Anass , Nhiri Mohamed
Published: June 2022

This study investigated the effect of Atriplex halimus extract on faba bean plants (Vicia faba). Three different concentrations (0.1% 0.25%, and 0.5%) of Atriplex halimus extract were applied. The obtained results indicated that the tested extract had a positive effect on several physiological and biochemical parameters of the tested plants, which led to enhancing their growth. A significant (p < 0.05) increase in plant metabolites and photosynthetic pigments content was observed in the treated plants. Furthermore, Atriplex halimus extract significantly improved the activities of enzymes involved in the activation of the carbon-nitrogen enzymatic system; including, phosphoenolpyruvate carboxylase (EC 4.1.1.31), isocitrate dehydrogenase (EC 1.1.1.42), Glutamine Synthase (EC 6.3.1.2) glutathione-S-transferase (EC 2.5.1.18), glutathione reductase (EC 1.8.1.7). This effect was more pronounced in plants treated with 0.25% of Atriplex halimus extract. Altogether, our results suggest that the application of the tested extract could be used as a promising plant growth biostimulant to improve faba bean plants’ growth and yield.
Promotionsaktivitäten bei der Implementation digitaler Medien an beruflichen Schulen
Authors: Wagner Anne , Gerholz Karl-Heinz
Published: June 2022

Die digitale Transformation erfordert von Schulen einen weitreichenden Wandel auf verschiedenen Ebenen, um digitale Medien als Innovation in den Unterrichtsalltag zu integrieren. Dabei gilt es, verschiedene Dimensionen der Schulentwicklung ganzheitlich anzusprechen. Bei derartigen inkrementellen Veränderungsprozessen einer Organisation können Barrieren auftreten, die den Innovationsprozess bremsen. Promotoren überwinden durch intensive und aktive Förderung der Innovation diese Barrieren. Dazu zählen Aktivitäten des Fach-, Macht-, Prozess- und Beziehungspromotors. Auf Basis einer Interviewstudie an 16 Berufsschulen in Baden-Württemberg (n=46) wird die Bedeutung und Ausgestaltung von Promotionsaktivitäten für den Implementationsprozess digitaler Medien an Schulen beleuchtet. Es zeigt sich, dass der Fachpromotor (z. B. Weitergabe von Wissen durch interne Schulungen) die grösste Rolle im Innovationsprozess der betrachteten Schulen spielt. Die Rolle des Machtpromotors bezieht sich auf die Bereitstellung von Ressourcen (z. B. finanzielle Mittel) und Schaffung günstiger Rahmenbedingungen. Der Prozesspromotor übernimmt überwiegend planerische und koordinierende Aufgaben und bringt beteiligte Akteure der Schule zusammen. Am wenigsten Bedeutung wird dem Beziehungspromotor beigemessen. Das Anregen und Pflegen von Kooperationen mit anderen Schulen oder Ausbildungsbetrieben wird von den Berufsschulen nur punktuell fokussiert, wobei genau diese externen Impulse wichtige Anreize zur Weiterentwicklung der eigenen Schule liefern können. Darauf aufbauend werden Handlungsempfehlungen zum Implementationsprozess digitaler Medien für Schulen und Bildungspolitik abgeleitet.
Automation of Beam and Jet functions at NNLO
Authors: Bell Guido , Brune Kevin , Das Goutam , Wald Marcel
Published: June 2022

We present a novel framework to streamline the calculation of jet and beam functions
to next-to-next-to-leading order (NNLO) in perturbation theory. By exploiting the
infrared behaviour of the collinear splitting functions, we factorise the singularities
with suitable phase-space parametrisations and perform the observable-dependent
integrations numerically. We have implemented our approach in the publicly available
code pySecDec and present first results for sample jet and beam functions.
The pion-photon transition form factor at two loops in QCD
Authors: Gao Jing , Huber Tobias , Ji Yao , Wang Yu-Ming
Published: June 2022

We report on the fully analytic calculation of the leading-power
contribution to the photon-pion transition form factor
\gamma \, \gamma^{\ast} \to \pi^0γγ*→π0
at two loops in QCD. The applied techniques are based on hard-collinear
factorization, together with modern multi-loop methods. We focus both,
on the technical details such as the treatment of evanescent operators,
and the phenomenological implications. Our results indicate that the
two-loop correction is numerically comparable to the one-loop effect in
the same kinematic domain. We also demonstrate that our results will
play a key role in disentangling various models for the twist-two pion
distribution amplitude thanks to the envisaged precision at Belle
II.
Feynman integrals for binary systems of black holes
Authors: Kreer Philipp Alexander , Runkel Robert , Weinzierl Stefan
Published: June 2022

The initial phase of the inspiral process of a binary black-hole system
can be described by perturbation theory.
At the third post-Minkowskian order a two-loop double box graph, known
as H-graph, contributes.
In this talk we report how all master integrals of the H-graph with equal masses can be expressed
up to weight four in terms of multiple polylogarithms.
We also discuss techniques for the unequal mass case.
The essential complication (and the focus of the talk) is the occurrence of several square roots.
TEXTBOOKS BASED ON STEM-CP (SCIENCE, TECHNOLOGY, ENGINEERING, MATHEMATICS, AND CONTEXTUAL PROBLEMS) MATERIALS ON VIRUSES TO IMPROVE CRITICAL THINKING SKILLS FOR HIGH SCHOOL STUDENTS
Authors:   Department of Science Education Magister, University of Jember, Jember, Indonesia 68121., Maya Oktaviani Ira , a Sutarto ,   Department of Science Education Magister, University of Jember, Jember, Indonesia 68121., Hariyadi Slamet ,   Department of Science Education Magister, University of Jember, Jember, Indonesia 68121.
Published: June 2022

This study aims to develop a STEM-CP based virus material textbook for grade X SMA students. The textbook is organized into a contextual textbook with problem-solving characteristics in the material Virus. Virus material was chosen based on contextual problems that are being faced by the world community, namely the COVID-19 pandemic. Therefore, students are expected to be be able to master material regarding the structure of the virus, as well as hone students critical thinking skills to solve problems in the right efforts to tackle the COVID-19 virus. The research method is Quasi Experiment with Pretest-Posttest without a control class. The data analysis was carried out by using mixed methods, which is the result of qualitative and quantitative data. The sample used was 30 students of class X SMA with problems. These results can be seen from the scores obtained by students. The prettest results of students critical thinking abilities before using STEM-CP-based virus textbooks were relatively low, namely 2,5 Unacceptable, but after using the value of students critical thinking skills relatively increased, namely 3,8 category Acceptable. This shows that the critical thinking skills possessed by students are better after students learn viral material using virus textbooks that are applied in learning. iresults of the N-gain scores of students in the Dessiminate class with an overall average of 0.80 in the high category This shows that STEM-Cp-based viral textbooks are effective in improving students cognitive abilities.
KNOWLEDGE REGARDING CONTRACEPTIVE METHODS AMONG MARRIED WOMEN OF REPRODUCTIVE AGE GROUP
Authors: Kapoor Neha , Kumari Bandna
Published: June 2022

Uncontrolled population growth is recognised as the single most important impediment to national development and birth control is the first important step woman must be taken to keep a check over uncontrolled population. Often family planning is used as synonym for birth control. The main objective of family planning programme is to assist individuals and couples to space and/or limit their children prevent unwanted pregnancy, improve their overall reproductive and child health. Contraception is one of the major components of Reproductive health programme. The use of contraceptive measures constituted the backbone of the programme. Therefore, assessing the current level of the knowledge regarding contraceptive devices among general population is very important so that the further planning can be done for educational teaching programmers to enhance their knowledge. Aim: This study was conducted to assess knowledge regarding selected contraceptive methods among married women attending gynae opd, Govt. Multi speciality hospital-16, Chandigarh. Setting and Design: Govt. Multi speciality hospital-16, Chandigarh was the setting for the study. Quantitative research approach and a descriptive research design was used for the study. Material and Methods: The study was conducted on a sample of 100 married women between the age group of 15-49 yrs of age attending gynae opd, Govt. Multi speciality hospital-16, Chandigarh using simple random sampling. Data was collected using self structured multiple choice questionnaire on contraceptive method usage. The collected data was organized, tabulated, analyzed and interpreted using descriptive and inferential statistics. Results: The findings of the study revealed that out of 100 married women majority i.e. 54% of the respondents had good level of knowledge and near about 40% had average knowledge. It has been concluded from the present study that respondents have basic knowledge of contraception but detailed knowledge about contraceptive methods was not known to the women. Therefore, the health talk was given to enhance the knowledge of the subjects regarding the topic.
LE SYNDROME DE LIMB BODY WALL COMPLEX A PROPOS DUN CAS ET REVUE DE LA LITTERATURE
Authors:   Service De Gynecologie Et Obstetrique, CHU Mohammed VI - Oujda,Faculte De Medecine Et De Pharmacie, Universite Mohammed Premier, Oujda, Maroc., Asmae Aidi , Harcha Kamal El. ,   Service De Gynecologie Et Obstetrique, CHU Mohammed VI - Oujda,Faculte De Medecine Et De Pharmacie, Universite Mohammed Premier, Oujda, Maroc., Hafssa Taheri ,   Service De Gynecologie Et Obstetrique, CHU Mohammed VI - Oujda,Faculte De Medecine Et De Pharmacie, Universite Mohammed Premier, Oujda, Maroc., Hanane Saadi ,   Service De Gynecologie Et Obstetrique, CHU Mohammed VI - Oujda,Faculte De Medecine Et De Pharmacie, Universite Mohammed Premier, Oujda, Maroc., Ahmed Mimouni ,   Service De Gynecologie Et Obstetrique, CHU Mohammed VI - Oujda,Faculte De Medecine Et De Pharmacie, Universite Mohammed Premier, Oujda, Maroc.
Published: June 2022

Limb body wallcomplex (LBWC) is a rare poly malformative syndrome of unknownorigin, comprising major anomalies of the ventral body wall (thoracoabdominal) associatedwithother anomalies, includingthose of the limbsthatmay range frompositionaldeformity to agenesis, unusualcraniofacial malformations, and a variety of visceral anomalies thatinclude the heart, lungs, and genitourinary system. Twophenotypes are describeddepending on the feto-placentalattachment. We report a case of LBWC diagnosed post partum in a stillbornwith the following malformations: a large anterioromphalocele, spina bifida withmeningocele, and severescoliosis. The lowerlimbsappearedasymmetricalwithbilateral club feetassociatedwithpolydactyly. The stillbirthadheres to the placenta by a very short cord of 3 cm comprising 2 arteries and a vein.
THE EXISTENCE OF PANCASILA VALUES IN THE CHRONICLE OF BANYUMAS KALIBENING AS AN EFFORT TO SETTLE LAWS BASED ON LOCAL WISDOM
Authors:   Associate Professor, Faculty of Law, JenderalSoedirman University, Indonesia., Taufiq Muhammad , Wahyu Handayani Sri ,   Senior Lecturer, Faculty of Law, JenderalSoedirman University, Indonesia., Sidik Maryono Antonius ,   Associate Professor, Faculty of Law, JenderalSoedirman University, Indonesia., a Supriyanto ,   Associate Professor, Faculty of Law, JenderalSoedirman University, Indonesia., Pamuji Kadar ,   Associate Professor, Faculty of Law, JenderalSoedirman University, Indonesia.
Published: June 2022

This study aims to analyze the existence of Pancasila values contained in Babad Banyumas Kalibening, as well as to prove whether it is true that the materialist cause of Pancasila is derived from the values extracted from Indonesia itself. Results show that there is a match between the values contained in Babad Banyumas Kalibening with the basic values, instrumental values, and practical values of Pancasila. The basic values of divinity appear in Sraddha/Sraddhanan ceremony which is still preserved now. The basic values of humanity can be seen in the teachings of gratitude and the value of helping each other. The basic value of unity can be seen in the tradition of friendship during the Sraddha ceremony. In addition, it also appears in the teachings of love for peace and non-violence, family values, and harmony. The basic values of democracy can be seen in the tradition of deliberation and consensus. The basic value of justice is seen in the construction of facilities and infrastructure to support the prosperity of the people, as well as the existence of taxes used to build and maintain the welfare of the community.
THROMBOSE DE LA VEINE PORTE DANS LE POST-PARTUM : SAVOIR Y PENSER !
Authors:   Service Gynecologie Obstetrique Hopital Militaire Dinstruction Mohamed V Rabat., Zineb Aboueddahab , Chaymaa Mohammadine ,   Service Gynecologie Obstetrique Hopital Militaire Dinstruction Mohamed V Rabat., Chaimae Aboueddahab ,   Service Cardiologie Hopital Avicenne Rabat., Hajar Adil ,   Service Radiologie Hopital Militaire Dinstruction Mohamed V Rabat., Hassani Moulay El. Mehdi El. ,   Service Gynecologie Obstetrique Hopital Militaire Dinstruction Mohamed V Rabat Universite Mohamed V, Faculte De Medecine Et De Pharmacie de Rabat., Abdellah Babahabib ,   Service Gynecologie Obstetrique Hopital Militaire Dinstruction Mohamed V Rabat Universite Mohamed V, Faculte De Medecine Et De Pharmacie de Rabat., Guelzim Khalid ,   Service Gynecologie Obstetrique Hopital Militaire Dinstruction Mohamed V Rabat Universite Mohamed V, Faculte De Medecine Et De Pharmacie de Rabat., Jaouad Kouach ,   Service Gynecologie Obstetrique Hopital Militaire Dinstruction Mohamed V Rabat Universite Mohamed V, Faculte De Medecine Et De Pharmacie de Rabat.
Published: June 2022

La thrombose de la veine porte est une complication rare de la grossesse et du post-partum dont le diagnostic clinique est souvent difficile. Les techniques de limagerie sont dun apport capital. La prise en charge repose sur une anticoagulation precoce et efficace. Nous rapportons le cas dune patiente sans antecedent personnel ou familial de thrombose veineuse, qui a presente une douleur abdominale aigue Ã J34 du post-partum et chez qui une thrombose veineuse de la veine porte a ete retrouvee. Les bilans ont revele une mutation du facteur V evoquant un caractÃ¨re secondaire.
E-SOFT - A VERY SIMPLE AND INNOVATIVE METHOD FOR SOLVING UNBALANCED ASSIGNMENT PROBLEMS
Authors: Murugesan R.
Published: June 2022

In this paper, we have proposed a noveland innovative method entitled E-SOFT fordetermining the optimal assignment plans to the unbalanced assignment problems (UAPs) and viewed its performance with the existing Hungarian method and the Mantra technique. The ESOFT algorithm has beeninheritedfrom the existing SOFTMIN algorithm developed for solving transportation problems and also extended for solving the UAPs.The Extended SOFTMIN method is in short termed as E-SOFT method. The performance of the proposed E-SOFT method over the Hungarian and Mantra methods has been tested on a set of 20 identified UAPs. Experimental results validate that the E-SOFT is an alternative simple method to solve UAPs.
KNOWLEDGE, ATTITUDE AND PRACTICE OF FAMILY PHYSICIANS TOWARD OBESITY COUNSELING IN CLUSTER ONE, RIYADH, SAUDI ARABIA
Authors: Eid Alruwaili Anwar , Alsuwaidan Salem , Menwer Alsulami Sattam , Mohammedalashhab Abdullah
Published: June 2022

Background: Because of the influence of culture and the fact that obesity is a new phenomenon caused by changing lifestyles, many physicians in Riyadh are not sufficiently empowered to provide thenecessary services to their clients. This study will identify the gaps in family physicians knowledge, attitude, and practice in Riyadh and recommend ways to design training programs in areas of knowledge, attitude, and practice when dealing with obesity and overweight cases. Methodology:This study is a cross-sectional study to assess the knowledge, attitude and practice of family physicians regarding obesity counseling in family practice centers, cluster one, Riyadh, Saudi Arabia. The sample and data were collected by a pre-tested questionnaire and analyzed by Statistical Package for Social Sciences (SPSS) method Results: The majority of the respondents depend on the waist circumference to diagnose obesity with 100% among the family physicians. The majority of the respondents think that obesity is a major health problem in Saudi Arabia with 125 (96.08%). Almost all family physicians (92.1%) agreed that is it better to have a training course in obesity management and 99 % thought that it is better to include obesity topic in health education program.Moreover, 100 % of the physicians would recommend lifestyle measure to decrease weight of regular physical exercise. Conclusion: Family physicians working in the primary health centers need to improve their knowledge and skills regarding obesity management.
STUDY OF IMPACT OF COVID 19 ON SMALL SCALE INDUSTRIES IN INDIA
Authors: Yeole Shraddha
Published: June 2022

India has been combating the corona virus disease also known as COVID - 19 pandemic for two years. This pandemic has affected not only India but also the entire world around. Several measures were imposed by the Government in order to stop the spread of this pandemic. During the first , second and third wave of COVID â€“ 19 pandemic, strict lockdown was imposed in India. In order to stop the spread of the covid 19 many small scale industries were shut down.This protocol had a very bad impact on small scale Industries. This research paper highlights the impact of the corona virus disease pandemic on the small scale manufacturing industries in India. The present paper starts with the introduction followed by research objectives, research type and the method of data collection have been stated. The analysis of challenges faced by the small businesses has also been discussed followed by the conclusion.
COMPARATIVE EVALUATION OF AIRTRAQ OPTICAL LARYNGOSCOPE AND HUGE MED VIDEO LARYNGOSCOPE FOR LARYNGEAL VISUALISATION AND ENDOTRACHEAL INTUBATION IN ADULTS WITH ANTICIPATED DIFFICULT INTUBATION
Authors: Kumar Raiger Lalit , Dave Tanuj , Choudhary Santosh , Sharma Sandeep
Published: June 2022

Background and Aims: Complications arising from difficult or failed tracheal intubation still remains a leading cause of anaesthetic morbidity and mortality.This has lead to development of multiple novel laryngoscopes. This study was designed to compare performance of Airtraq optical laryngoscope with Huge Med Video laryngoscope for laryngeal visualisation and endotracheal intubation. Material and Methods: In this prospective randomized clinical study, seventy ASA grade I and II patients aged 18-60 years of either gender scheduled for elective surgery under general anesthesia were randomly assigned into two groups:Group A and group B in which laryngoscopy and tracheal intubation was performed using Airtraq optical laryngoscope(group A) and HugeMed video laryngoscope(group B) respectively. The time taken and number of attempts for endotracheal intubation along with Cormack Lehane(CL) grading were recorded. Heart rate and blood pressure(SBP, DBP, MAP) were recorded at predefined time intervals. Result: Mean intubation time was 15.3Â±11.791sec in group A compared to 34.1011Â±17.471sec in group B.Majority of patients in both groups were intubated in first attempt (97.1% and 94.3% in group A and group B respectively). Patients in both groups remained haemodynamically stable in the post intubation period. On comparing the ease of intubation, majority of patients in group A and group B had CL grade I, very few patients in group A [6(17.1%)] and in group B [2(5.7%)] had CL grade II. Conclusion: Both Airtraq and Hug Med video laryngoscopes are effective devices for laryngoscopy and endotracheal intubation with high success rate of intubation although time needed for tracheal intubation is shorter with Airtraq optical laryngoscope.
COVID-19 AMONG NEONATES: EXPERIENCE FROM AN SNCU OF A TERTIARY CARE HOSPITAL IN EASTERN INDIA
Authors: Das Arijit , Biswas Nirmay , Mondal Monojit
Published: June 2022

Background: Coronavirus disease 2019 (COVID-19) pandemic has spread to every corner of the globe with immense rapidity. The clinical presentation of neonates due to COVID19 is poorly understood. Aim and Objectives: The study assessed the clinical profile of neonates with COVID-19 from the Special Newborn Care Unit (SNCU) of a tertiary care hospital in eastern India. Materials and Methods: Data from the hospital record section was retrieved and bed head tickets (BHT) were collected. A thorough review of the BHTs was done. Retrieved data was presented in tabulated form and analyzed. Results: Out of the 285 neonates tested for COVID19 by reverse transcriptase-polymerase chain reaction (RT-PCR) from the nasopharyngeal swab, 23 tested positive. Fever was the most common presenting complaint in 9 cases (39.13%). Respiratory distress was the clinical presentation in 5 cases (21.73%), while 4 cases (17.39%) presented with diarrhea. The other symptoms included fever and cough with nasal congestion, found in 2 cases (8.69%). Mother being positive for COVID-19 was found to be a risk factor for COVID-19 in 3 (13.04%) cases. Conclusions: It is essential to screen neonates not only with the history of COVID-19 positive mothers but also other neonates presenting with symptoms suggestive of COVID-19.
CHARACTERISTICS OF HALLERS CELLS A PREVALENCE BASED PANORAMIC RETROSPECTIVE ANALYSIS
Authors: Kanjani Varsha , Gupta Neel , Singh Bhadouria Mukesh , Poddar Prithul , Agarwal Mansi , Ahmed Ajaz
Published: June 2022

Background: Hallers cells, seen as incidental findings on radiographs, are located at the floor of the orbit and superior most aspect of the maxillary sinus. These cells are attributed to the anatomical variations in the growth and development of nose and paranasal sinuses leading to clinically significant symptoms such as headache, chronic cough, sinusitis, orofacial pain, impaired nasal breathing and various maxillofacial region associated pathologies.Therefore, the present study was carried out on hallers cells considering their clinical significance. Aims and Objectives:To determine the prevalence and radiographic characteristics of hallers cells using digital panoramic radiographs. Materials and Methods:The present retrospective study was carried out in a diagnostic setup, dental hospital, Bengaluru, Karnataka over the period of two years. Initially, the study group consists of 2376 participants, out of which 1800 met the inclusion criteria and were randomly enrolled in the studywith age range of 10 - 60 years. The digital panoramic images obtained were interpreted for presence and characteristics of hallers cells by trained oral and maxillofacial radiologists according to Ahmad M etals criteria. Results:Out of 1800 digital panoramic radiographs the hallers cells were seen in 214 radiographs of study participants, stating the prevalence rate of 11.88 %. The mean age of the study participants with hallers cells were 27.46 Â± 17.93 years.Majority of cells seen on digital panoramic radiographs wereround (35.98%) and triangular (5.14%) in shape with unilocular appearance. A significant difference was observed with the shape of the hallers cells with p value of 0.001. Conclusion: The prevalence and characteristics of the hallers cells is in accordance with the various studies published in literature with highest number of panoramic radiographs taken into consideration till our knowledge. The incidental appearance of hallers cells on panoramic radiographs has its own significance in diagnosing various pathologies along with avoiding intraoperative complications in endonasal surgeries.
PALYNOLOGY OF SOME SPECIES IN THE FAMILY CUCURBITACEAE FROM NIGERIA
Authors:   Department of Botany, Obafemi Awolowo University, Ile-Ife, Osun-State., O. Adedeji , T.C Omotayo ,   Department of Botany, Obafemi Awolowo University, Ile-Ife, Osun-State.
Published: June 2022

Pollen morphology of ten (10) species representing nine (9) genera, two (2) varieties in the family Cucurbitaceae from Nigeria has been examined under light microscope. The pollen grains are largely monads. Exine wall ornamentation is most often reticulate in all the species of the family studied with the exception of pollens in Cucurbita maxima Duch. which are echinate, this is a diagnostic character for this species. Cell wall thickness is the least variable among all the characters studied. Almost all types of pollen shape classes have been observed within this family, namely spheroidal, subprolate, oblate-spheroidal, prolate-spheroidal, suboblate and prolate, with more than one shape type occurring in a species. It is worthy of note that pollen shape and aperture type can be used to delimit Lagenaria siceraria (spatulate fruit shape) from Lagenaria siceraria (oval fruit shape). However, the shapes are the same in Citrullus lanatus (black seeds water melon) and Citrullus lanatus (brown seeds water melon). Three (3) types of apertures, porate, colpate (very occasionally) and colporate are documented for the family in this study, while seven (7) pollen types have been distinguished based on the apertures: monoporate, monocolpate, bicolporate, triporate, tricolporate, tetraporate and tetracolporate. Tricolporate pollens were observed to occur more frequently than other apertural types. Pollen grains belong to the size categories Media and Magna and only very occasionally in the Minuta category. The implication of these size categories in the reproductive success of the plants in this family is highlighted.
MINDFULNESS AS A BOOSTER FOR WORKPLACE WELLBEING: ITS SIGNIFICANCE AND EFFECTS
Authors:   Founding Head, Department of Psychology., Mahanta Dimpy , Chakravarty Kamakshi ,   Student, M.A. Psychology Cotton University.
Published: June 2022

The demanding and stressful nature of the workplace environment have become detrimental to the physical and mental health of the workers, especially in the present scenario. Work overload,deadlines, sudden and rapid changes in the workplace all have negatively contributed towards the wellbeing of the workers. This has led to an increase in various illnesses, both physically and mentally and has also impacted the organization leading to conflicts, employee turnover, unionism and many more such issues. As such, different efforts are undertaken to improve occupational wellbeing. One such intervention involves being Mindful or completely focused and conscious at work. Mindfulness is the non-judgmental awareness of and attention to present moment experiences. The concept of Mindfulness has drawn considerable interest among organizational scholars and practitioners. It is largely beneficial for workers wellbeing asaccording to several researches, it is seen to be associated with job satisfaction and low burnout. However, this concept is still lacking importance. In the light of todays complex society, an understanding of mindfulness at work has gained utmost importance. The presented paper discusses this concept taking into consideration a number of factors such as implementation of mindfulness and its qualities. The paper also discusses the significance and effects that mindfulness has upon the workers. Apart from this, the implications of mindfulness in the emerging workplace and employee wellbeing are also presented.
MILK PRODUCTIVITY OF LOCAL BOVINE FEMALES INSEMINATED IN SOUTH TOGO
Authors:   Ecole Superieure dAgronomie, Universite de Lome ESA/UL, BP : 1515 Lome-Togo., Kpassi Seme , Were Pitala ,   Ecole Superieure dAgronomie, Universite de Lome ESA/UL, BP : 1515 Lome-Togo., Atouga Yembliman Djagba ,   Institut Togolais de Recherche Agronomique Centre de Recherche Agronomique-Savane Humide, (ITRA/CRASH) Station de Kolokope, BP : 01 Anie., Fatoumata Coulibaly ,   Universite Peleforo Gon COULIBALY, BP : 1328 Korhogo, Cote., koudoua Piklewe Alawi ,   Ranch de Namiele (Mango) de la Direction de lElevage du MinistÃ¨re de lAgriculture, de lelevage et du Developpement Rural (MAEDR),59 Rue de la Kozah, BP : 4041 Lome., Essoro Assih ,   Coordination Togolaise des Organisations Paysannes et des Producteurs Agricoles (CTOP). BÃ¨ Klikame, BP : 20046 Lome, Togo., Mensah Delako Kotoe ,   Institut Togolais de Recherche Agronomique Centre de Recherche Agronomique-zone ForestiÃ¨re (ITRA/CRAF) Station dAvetonou, BP 90 Kpalime, Togo.
Published: June 2022

Cows milk plays a key role in livestock systems and in human nutrition. The study consisted of determining the milk productivity of twenty-two (22) cows subjected to artificial insemination for the purpose of genetic improvement of milk. The methodology used is the measurement of milk per day per cow as of the second week of delivery at a frequency of ten (10) days during six (06) months. The results of this study yielded an average milk productivity of 0.7 Â± 0.1 liters over the six (06) months of collection. No significant difference (p> 0.05) in milk productivity was observed in relation to the group of cattle studied, the site of establishment of the farms and the lactation rank. In conclusion, this research will serve as a basis for assessing the milk productivity of Metis resulting from artificial insemination.
A STUDY ON FASTING LIPID PROFILE IN NON-DIABETIC STROKE PATIENTS
Authors:   Assistant Professor, Department of Gen. Medicine, Sri Aurobindo Medical College & PG Institute-Indore (M.P.)., Parmar Deepak , Singh Shashank ,   Postgraduate student, Department of Gen. Medicine, Sri Aurobindo Medical College & PG Institute-Indore (M.P.)., Jha R.K. ,   Prof. & HOD, Department of Gen. Medicine, Sri Aurobindo Medical College & PG Institute-Indore (M.P.).
Published: June 2022

Objectives: To study serum fasting lipid profile in patients with acute ischaemic stroke & to determine the significant correlation between them. To assess the role of aggressive control of dyslipidemia on recovery of stroke. Setting: Patients admitted with Ischemic stroke into the Acute Medical Care Unit and Medical Wards in the department of General Medicine, SAIMS Medical Indore, from December 2019 to November 2021, were taken for the study. Patients were subjected to a Fasting lipid profile at presentation and followedâ€“ up at 12 weeks and rechecked the fasting lipid profile and correlated with the recovery of stroke. Participants: A total of 50 Ischaemic stroke patients- 33 males and 17 females, participated. All subjects were above 50 years. Patients with suspected emboli of cardiac origin, haemorrhagic stroke, diabetes and h/o of head injury/usage of anticoagulant drugs were excluded from the study. None of the patients was on diet (or) other modifications to lower plasma lipid levels. Results: S.T.C was abnormal in 11 patients at onset and 8 pts after three months of statin therapy. TG was abnormal in 34 patients at the beginning and 35 pts after three months of treatment. LDL was abnormal in 32 patients at the beginning and 20 pts after three months of statin therapy. HDL was abnormal in 38 patients at onset and 35 pts after three months of treatment. VLDL was abnormal in 34 pts at the beginning & 35 pts after three months of statin therapy. After three months, the MRS score of most of the patients was 0 -1(21 pts), followed by a score of 0 (15 pts). Correlation between mNIHSS score and lipid profile showed a significant clinical improvement with reduction in the LDL levels & the corresponding p- value is .000, which is highly effective. Correlation between MRS score and lipid profile showed a good clinical outcome with a reduction in LDL levels & the corresponding p-value is 0.26, which is substantial. Conclusion: This study shows that higher levels of S.T.C, TG, LDL, VLDL is not the only significant risk factor for the occurrence of ischaemic CVD. A decrease in LDL levels shows significant improvement in clinical outcomes.
EARLY CHILDHOOD CARIES AND INFANT ORAL HEALTH -KNOWLEDGE, ATTITUDE, PRACTICES AMONG PEDIATRICIANS AND GENERAL PRACTITIONERS IN UDUPI DISTRICT
Authors:   Postgraduate Student, Department of Pediatric and Preventive Dentistry AJ Institute of Dental Sciences Karnataka., a Barkathunnisa , M.S Shreya ,   Postgraduate Student, Department of Pediatric and Preventive Dentistry AJ Institute of Dental Sciences Karnataka., b Anusha ,   Postgraduate Student, Department of Pediatric and Preventive Dentistry AJ Institute of Dental Sciences Karnataka., P.K Athira ,   Reader, Department of Pediatric and Preventive Dentistry, AJ Institute of Dental Sciences Karnataka., Krishnan E. Anandhu ,   Reader, Department of Pediatric and Preventive Dentistry, AJ Institute of Dental Sciences Karnataka., Shetty Krithika ,   Postgraduate Student, Department of Pediatric and Preventive Dentistry AJ Institute of Dental Sciences Karnataka., V. Shetty Kushal ,   Reader, Department of Pediatric and Preventive Dentistry, AJ Institute of Dental Sciences Karnataka., B. Sowmya ,   Professor and Head, Department of Pediatric and Preventive Dentistry, AJ Institute of Dental Sciences Karnataka.
Published: June 2022

Background:Dental caries is a multifactorial microbial infectious disease characterized by demineralization of the inorganic and destruction of the organic substance of the tooth. Early Childhood Caries(ECC) affects children at the early stages of development and can have a detrimental effect on their growth and development. Pediatricians are the first healthcare personnel that children come in contact with and should be trained to identify and screen dental caries cases and refer to the concerned dentist at the earliest. Objectives:The objectives of the study were to assess the level of Knowledge, Attitude and Practices related to Early Childhood Caries among Pediatricians in Udupi District. Material and Methods: A prospective study was conducted among Pediatricians in Udupi district, a 20-item google form questionnaire was sent by means of social media (Whatsapp). The responses obtained were used to assess their knowledge, attitude and practices. Results:The results of the study show that the pediatricians have good knowledge with respect to ECC, but need to improve on their attitude and practice with relation to ECC. Conclusion: Based on the findings of this study, it was proven that Pediatricians have adequate knowledge with regard to ECC.
COVID-19 PANDEMIC: LESSONS LEARNT AND THE NEW NORMAL AS I SEE IT
Authors: Kaur Manjot , Singh Khanna Jaspreet , Singh H.P , a Navjot , Jindal Rajiv , b Somnath , Jindal Ravi
Published: June 2022

Covid -19 has brought many changes in our daily practices both professional and personal. It has instilled a new sense of health awareness among the masses. These beliefs and practices might seem restrictive and difficult at first but it is not unusual and impossible to adapt. It has unlocked a new world requiring productive use of technology, respecting enforced rules and policies, discipline in life and financial responsibilities.
The Development of E-Butler Hotel Service Robot
Authors: Clemons Benedick , Ferdyan Ignatius , Anderson Kevin
Published: June 2022

A hotel is a place that provides accommodation, food, drink, and services for people traveling far from home. During this pandemic, many hotels started to apply strict health protocols for social distancing by reducing the number of their employees. For this purpose, we developed a service robot for some works in a hotel called E-butler. E -butler robots can provide amenities delivery service for the guest. The butler application for ordering amenities was developed by using MIT App Inventor as a prototype and will be developed further using Flutter. While the hardware of the E-butler robot is developed using the Mecanum wheels platform and Arduino for controlling the movement of the robot. Furthermore, the e-butler robot is equipped with teleconference devices based on Jetson Nano to facilitate communication between hotel employees and guests. Based on our evaluation, the butler robots can carry out the main task of E-butler, which can replace human butlers in hotels.
Self-Reliance and Personality Parameters in High School Students
Authors: Krecan Zoya , Morozov Evgeny
Published: June 2022

The article features the content characteristics of self-reliance in adolescent students in conjunction with such personality parameters as adaptability and behavior strategies. The research objective was to identify, substantiate, and interpret specific manifestations of psychological space integrity in order to improve academic environment. The article describes the content of the self-reliance phenomenon and introduces the results of a study of how various academic environments affect its development, e.g., in boarding-school students. The experiment involved 46 comprehensive school students aged 16–17 and covered the dependence of self-reliance on gender factor and personality. The results can help improve the organization of academic space environment.
Concept and Correlation of the Principles of Proper and Specific Performance of Civil Obligations
Authors: Senotrusova Evgeniya
Published: June 2022

The article features the principles of proper and specific performance of civil obligations and their correlation. The principle of proper execution presupposes that the debtor's actions comply with the terms of the agreement and the requirements of the law or customs in terms of the provision of the proper subject by the proper person in the proper place and at the proper time. This principle is universal for all stages. The principle of specific performance is characteristic of the abnormal stage: it is when the debtor refuses to perform the in-kind financial obligations. The author analyzed Articles 308.3 and 396 of the Civil Code of the Russian Federation. They contain rules on the ratio of the award to execution in kind with other ways of protecting civil rights. The article introduces negative (objective and subjective) and positive limits of the principle of specific performance. The principle of specific performance is not the same as the reality of performance as an element of the principle of specific performance (proper subject). The article contains some ideas on how to improve the civil legislation.
Can Nanomedicinal Approaches Provide an Edge to the Efficacy of Tyrosine Kinase Inhibitors?
Authors: Indermun Sunaina , Kumar Pradeep , Govender Mershen , Choonara Yahya E.
Published: June 2022

Tyrosine kinase inhibitors (TKIs) are effective drug molecules for the treatment of various cancers. Nanomedicinal interventions and approaches may not only provide carrying capacities for TKIs but also potentially target tumor-specific environments and even cellular compartments. Nano-inspired drug delivery systems may hence enhance the efficacy of the drugs through enhanced tumour-availability resulting in greater efficacy and decreased side effects. A variety of nanosystems have been developed for the delivery of TKIs for the enhanced treatment of cancers, each with their own preparation methods and physicochemical properties. This review will therefore discuss the applicability of nano-interventions towards combination therapies, dose reduction, and greater potential treatment outcomes. The individual nanosystems have been highlighted with emphasis on the developed systems and their efficacy against various cancer cell lines and models.
Relevance of ABC Transporters in Drug Development
Authors: Nwabufo Chukwunonso K.
Published: June 2022

ATP-binding cassette (ABC) transporters play a critical role in protecting vital organs such as the brain
and placenta against xenobiotics, as well as in modulating the pharmacological and toxicological profile of several
drug candidates by restricting their penetration through cellular and tissue barriers. This review paper describes the
structure and function of ABC transporters as well as the role of P-glycoprotein, multidrug resistance-associated
protein 2 and breast cancer resistance protein in the disposition of drugs. Furthermore, a review of the in vitro and
in vivo techniques for evaluating the interaction between drugs and ABC transporters is provided.