bluuebunny/crossref_metadata_2025 huggingface dataset:
Hilar lymphadenopathy, development of tubulointerstitial nephritis, and dense deposit disease following Pfizer-BioNTech COVID-19 vaccination
Authors: Nakamura Hironori , Ueda Michiko , Anayama Mariko , Makino Mutsuki , Makino Yasushi
Published: December 2022

Despite the reports on glomerulonephritis associated with COVID-19 mRNA vaccines, no study has reported about the dense deposit disease (DDD). Here, we present a case of hilar lymphadenopathy after the COVID-19 mRNA vaccination, following which the patient developed tubulointerstitial nephritis (TIN) and DDD. A 74-year-old man received his second dose of mRNA vaccine, and on the next day, he developed fever, urticaria, and dyspnea. On further examination, he had pleural effusion and right hilar lymphadenopathies, which were improved with conservative therapy. After 48 days of the second vaccination, he developed renal dysfunction and new-onset hematuria. Light microscopy findings by renal biopsy revealed apparent mesangial cell proliferation, increased mesangial matrix in the glomeruli, and diffuse inflammatory cell infiltration in the interstitium. Immunofluorescence analysis revealed 1 + positive results for IgG and IgM, negative results for IgA, and 2 + positive results for C3 with a garland pattern on the capillary walls. Electron microscopy revealed that severe cell proliferation in the capillary rumen, and continuous, thickened, and highly dark-stained spotty dense deposits in the glomerular basement membrane; and noncontinuous spotty dense deposits in the tubular basement membrane. Based on the decrease in C3 and pathological findings, TIN accompanied with DDD was diagnosed. The mRNA vaccine might have contributed to the development of lymphadenopathies, TIN, and DDD in this case. Moreover, TIN and DDD might be associated with the activated alternative pathway induced by the mRNA vaccine.
Nutritional Management of Children with Food Allergies
Authors: Wright K. , Feeney M. , Yerlett N. , Meyer Rosan
Published: December 2022

Purpose of the Review

The purpose of the review is to review the evidence for the nutritional management of paediatric food allergy and provide a practical approach for healthcare professionals working in this area.

Recent Findings

Dietary elimination remains the mainstay for management of food allergies in children. However, the elimination of food allergens increases the risk for growth faltering, micronutrient deficiencies and feeding difficulties. Breastmilk remains the ideal source of nutrition for infants, but when not available, the vast majority will tolerate an extensively hydrolysed formula, and rice hydrolysate has also been suggested as a suitable alternative. Only in severe cases, including anaphylaxis, eosinophilic oesophagitis and growth faltering, is an amino acid formula indicated. The early introduction of peanut and egg and avoiding the delay in the introduction of other allergens, when not already allergic, has been highlighted by recent studies.

Whilst the elimination of allergens increases the risk of developing poor growth, micronutrient deficiencies and feeding difficulties, optimal, early dietary input, including advice on active introduction of allergens and alternative feeds, ideally from a registered dietitian/nutritionist, may be prevent and improve outcomes.
Ballistic Evaluation of Aluminum Alloy (AA) 7075 Plate Repaired by Additive Friction Stir Deposition Using AA7075 Feedstock
Authors: Stubblefield G. G. , Williams M. B. , Munther M. , Tew J. Z. , Rowe R. A. , Barkey M. E. , Jordon J. B. , Allison P. G.
Published: December 2022

In this work, Additive Friction Stir Deposition (AFSD) was employed for ballistic repair of AA7075-T6511 plates. After penetration with 7.62 × 51 mm FMJ rounds, the AA7075-T6511 plates were repaired by AFSD using the same AA7075-T6511 feedstock material. The repaired plates were impacted and penetrated with the same 7.62 × 51 mm FMJ rounds, and the surface damage characteristics including the initial and residual velocities were compared against the control wrought plates. The AFSD process successfully repaired the damaged control plates with the same alloy, without any observable defects such as large cracks or pores prior to impact tests. Although the surface appeared pristine other than milling marks, the surface damage characteristics of the repaired plates were significantly different than the control plates. The increase of spalling and petalling with the repaired material can be attributed to the thermomechanical processing of AFSD, which would alter the control T6511 temper of the feedstock due to coarsening of strengthening precipitates. A cross-sectioned repaired plate was analyzed using microhardness plots and optical microscopy to illustrate the effectiveness of the AFSD process for ballistic repair by depositing the same material into the damaged area. Despite the surface damage discrepancy, the repaired plates performed similarly to the control plates with respect to initial and residual velocities.

Graphical Abstract
Mainstream or margins? The changing role of environmental education in Irish primary school curricula, 1872 to 2021
Authors: O’Malley Sarah , Pierce John
Published: December 2022

This article investigates the position of environmental education in the primary school curriculum over the past 150 years in the Republic of Ireland. The extent of how wider social, political, and cultural developments influence the way in which teachers and learners experience environmental education can be seen through the curricular changes. To achieve this, the five primary school curricula from 1872 to the present day were reviewed with respect to the amount of environmental education included in them. This review demonstrates a dramatic change in socio-environmental relations in contemporary Irish society during the 19th and 20th centuries, as reflected through primary school curricula. Environmental education is included, in some form, in all five Irish primary curricula over the 150-year period studied, though it does appear on the margins of some curricula as a subject, or part of a subject, that can be taught at the discretion of the teacher. Such a peripheral situation of environmental education is not unique to Ireland’s curricula, and this investigation provides a greater understanding of the broader influences on the status of environmental education overall in Irish education.
Cost-effective equipment for surface pre-treatment for cleaning and excitation of substrates in semiconductor technology
Authors: Weber Dominik , Heimburger Robert , Schondelmaier Gianina , Junghans Toni , Zetzl Annika , Zahn Dietrich R. T. , Schondelmaier Daniel
Published: December 2022

This article presents a cost-effective ultraviolet-ozone cleaner (UV/O3 Cleaner) for surface pre-treatment of substrates in the field of semiconductor technology. The cleaner consists of two chambers, the upper one contains the electronics, including the time counter. The lower chamber contains the two UV sterilisation lamps and a UV reflector of anodized aluminium, which confines the area of high Ozone concentration in the area of interest. The device is successfully used for surface cleaning and modification of different materials. To this end, the two important wavelengths 253.7 nm (excitation of organic residues) and 184.9 nm (production of ozone from the atmospheric environment as a strong oxidant) were first detected. The effectiveness of UV/O3 cleaning is demonstrated by improving the properties of indium tin oxide (ITO) for OLED fabrication. The contact angle of water to ITO could be reduced from 90° to 3° and for diiodomethane, it was reduced from 55° to 31° within the 10 min of irradiation. This greatly improved wettability for polar and non-polar liquids can increase the flexibility in further process control. In addition, an improvement in wettability is characterized by measuring the contact angles for titanium dioxide (TiO2) and polydimethylsiloxane (PDMS). The contact angle of water to TiO2 decreased from 70° to 10°, and that of diiodomethane to TiO2 from 54° to 31°. The wettability of PDMS was also greatly increased. Here, the contact angle of water was reduced from 109° to 24° and the contact angle to diiodomethane from 89° to 49°.

Article Highlights

We report a cost-effective dry-cleaning device for surface cleaning and modification based on ultraviolet-ozone irradiation.

Contact angle measurements show an increase of wettability for different materials due to surface modification.

The UVO3 pre-treatment improves layer formation and optoelectrical properties of OLEDs.
Impact of Irrigation with Wastewater on Accumulation of Heavy Metals in Phaseolus vulgaris L. and Its Remediation
Authors: Nowwar Abdelatti I. , Farghal Ibrahim I. , Ismail Mohamed A. , Amin Mohamed A.
Published: December 2022

This study investigates the effects of Spirulina platensis, Chlorella vulgaris, leaves powder of Salix alba, and ethylenediaminetetraacetic acid treatments on the biochemical and yield traits of Phaseolus plants grown under wastewater irrigation. In addition, to assess the uptake and accumulation of heavy metals into the edible plant part. Water samples were obtained from each irrigation source (fresh tap water and untreated wastewater collected from El-Rahawy drain, Giza, Egypt); the plants were treated with our treatments (3 g per kg soil) at the beginning of the experiment (mixed fully into the soil). The results observed that the irrigation of Phaseolus plants with wastewater markedly stimulated the free proline contents, total phenols, superoxide dismutase, catalase, peroxidase, polyphenol oxidase, lipid peroxidation, and abscisic acid throughout the two growth stages. Indole acetic acid, gibberellic acid, yield parameters, total soluble carbohydrate, and protein in seeds were significantly reduced. The concentrations of nickel (Ni), cadmium (Cd), lead (Pb), and cobalt (Co) in Phaseolus seeds were significantly increased beyond recommended limits set by international organizations. However, our treatments significantly reduced the contents of Ni, Cd, Pb, and Co in seeds; free proline; total phenols; superoxide dismutase; catalase; peroxidase; polyphenol oxidase; lipid peroxidation; and abscisic acid in Phaseolus plants. Moreover, indole acetic acid, gibberellic acid, all yield traits, and seed components were enhanced. This study concluded that Spirulina platensis and salix leaves powder being economically and environmentally friendly can be considered an efficient strategy to mitigate the harmful effects of wastewater on plants.
The longest recorded movement of an inshore common bottlenose dolphin (Tursiops truncatus)
Authors: Genov Tilen , Železnik Jure , Bruno Chiara , Ascheri Davide , Fontanesi Elena , Blasi Monica Francesca
Published: December 2022

Information on movements and connectivity among populations of animals is important for the delineation of units to conserve, so that demographic parameters, such as abundance, fecundity and mortality, can be placed in an appropriate population and conservation context. Common bottlenose dolphins (Tursiops truncatus) are often considered relatively ‘resident’ and demonstrating strong site fidelity to specific areas. However, this perception may partly be an artefact of the distribution and ‘habitat use’ of cetacean researchers, rather than animals themselves, and bottlenose dolphins have been shown to be capable of substantial movements, often in relatively short periods of time. Here, we report on two long-distance movements of a common bottlenose dolphin within the Mediterranean Sea, across the Tyrrhenian, Ionian and Adriatic Seas, and subsequently back across all three seas to Ligurian Sea, making these the two longest recorded movement for this species in the Mediterranean Sea to date and some of the longest in the world. We also review published records of long-distance movements in this species worldwide. This study highlights the utility of photo-identification and the importance of regional data sharing. We argue that photo-identification comparisons are always worthwhile and the results are informative regardless of the presence or absence of matches, especially with the ongoing advances in automated matching software.
Healthcare workers and monkeypox: The case for risk mitigation
Authors: Manirambona Emery , Felicilda Lopez Jaifred Christian , Nduwimana Colyse , Okesanya Olalekan John , Mbonimpaye Régis , Musa Shuaibu Saidu , Usman Abubakar Haruna , Lucero-Prisno Don Eliseo
Published: December 2022

Potentially more at risk of contracting the monkeypox virus are healthcare workers. Most healthcare workers come into direct contact with the disease’s infected people, which can spread directly and indirectly. Healthcare professionals must contact patients with the disease and any infected objects or fluids to effectively manage the disease, which further increases the risk of transmission. It is crucial to put safety measures in place and protect healthcare workers. To stop the spread of the monkeypox virus, countries must develop the necessary safeguards and countermeasures. In this emergency, healthcare systems must be strengthened. All healthcare systems should offer staff sufficient personal protective equipment (PPE) and facilitate risk assessment among those with a high risk of exposure. Any suspected case of monkeypox requires caution on the part of healthcare professionals. They must abide by infection control safety rules and protective measures.
Stories of Stroke
Authors: Caplan Louis R. , Aggarwal Aishwarya
Published: December 2022

Stroke is one of the most important and most feared conditions known to man. The threat of stroke is important to all people. What could be more devastating than to lose the ability to speak, move a limb, stand, talk, see, read, feel write or even think?

This book brings together ideas, events and advances – the stories – before and during the 20th Century through the accounts of global experts in the field, many of them having been first-hand witnesses to progress. Focusing on selected stories of stroke, this book offers a readable summary of the most dramatic and extensive changes in knowledge about stroke and in caring for stroke patients. Of interest to anyone interested in neurosciences and for physicians caring for stroke patients, this book informs on moving forward, by looking to how we got to where we are.
Transitional Morphology
Authors: Mattiello Elisa
Published: December 2022

Combining Forms (CFs) are a major morphological phenomenon in Modern English, yet while they have been discussed in some morphological literature, no full-length study has been devoted to this topic so far. This pioneering book addresses that gap by providing a framework in which CFs are marked as distinct from their neighbouring categories such as abbreviations and blending. It splits CFs into four distinct categories – neoclassical (e.g. bio-therapy, zoo-logy), abbreviated (e.g. e-reader, econo-politics), secreted (e.g. oil-gate, computer-holic) and splinters (e.g. docu- from documentary in docudrama). It shows that the notion of CF spans a wide spectrum of processes, from regular composition to abbreviation, from blending to analogy, and schema. Modern and emerging English CFs are analysed by adopting a corpus-based approach, and measuring their realised, expanding, and potential productivity. Comprehensive yet accessible, it is essential reading for researchers and advanced students of morphology, English historical linguistics, corpus linguistics, and lexicography.
Appropriateness of antibiotic use in patients with and without altered mental status diagnosed with a urinary tract infection
Authors: Anderson Connor M. , VanHoose Jeremy D. , Burgess Donna R. , Burgess David S. , Schadler Aric , Porterfield J. Zachary , Wallace Katie L.
Published: December 2022

Objective:

The objective of this study was to determine antibiotic appropriateness based on Loeb minimum criteria (LMC) in patients with and without altered mental status (AMS).

Design:

Retrospective, quasi-experimental study assessing pooled data from 3 periods pertaining to the implementation of a UTI management guideline.

Setting:

Academic medical center in Lexington, Kentucky.

Patients:

Adult patients aged ≥18 years with a collected urinalysis receiving antimicrobial therapy for a UTI indication.

Methods:

Appropriateness of UTI management was assessed in patients prior to an institutional UTI guideline, after guideline introduction and education, and after implementation of a prospective audit-and-feedback stewardship intervention from September to November 2017–2019. Patient data were pooled and compared between patients noted to have AMS versus those with classic UTI symptoms. Loeb minimum criteria were used to determine whether UTI diagnosis and treatment was warranted.

Results:

In total, 600 patients were included in the study. AMS was one of the most common indications for testing across the 3 periods (19%–30.5%). Among those with AMS, 25 patients (16.7%) met LMC, significantly less than the 151 points (33.6%) without AMS (P < .001).

Conclusions:

Patients with AMS are prescribed antibiotic therapy without symptoms indicative of UTI at a higher rate than those without AMS, according to LMC. Further antimicrobial stewardship efforts should focus on prescriber education and development of clearly defined criteria for patients with and without AMS.
Lack of significant seasonal association between serum 25(OH)D concentration, muscle mass and strength in postmenopausal women from the D-FINES longitudinal study
Authors: Welford Anneka E. , Darling Andrea L. , Allison Sarah J. , Lanham-New Susan A. , Greig Carolyn A.
Published: December 2022

The aim of the present study was to assess the seasonal relationship between serum 25(OH)D concentration, lean mass and muscle strength. This was a secondary data analysis of a subgroup of 102 postmenopausal women participating in the 2006–2007 D-FINES (Vitamin D, Food Intake, Nutrition and Exposure to Sunlight in Southern England) study. The cohort was assessed as two age subgroups: <65 years (n=80) and ≥65 years (n=22). Outcome measures included lean mass (DXA), muscle strength (handgrip dynamometry) and serum 25(OH)D concentration (enzymeimmunoassay). Derived outcomes included appendicular skeletal muscle mass (ASM) and relative appendicular skeletal muscle index (RASM). Sarcopenia status was assessed using the European Working Group on Sarcopenia in Older People 2018 criteria. Non-parametric partial correlation using BMI as a covariate was used to evaluate the study aims. There were no statistically significant associations between total lean mass, ASM or RASM and 25(OH)D in any group at any season. There was a trend for handgrip strength to be positively associated with serum 25(OH)D concentration. There was a trend showing a higher prevalence of sarcopenia in women ≥65 years. Sarcopenia status appeared transient for five women. In conclusion, the present study found no significant association between vitamin D status and functional indicators of musculoskeletal health, which were additionally not affected by season.
Open Innovation in Ecuadorian SMEs: The Importance of Strategy and the Moderating Effect of Control
Authors: Madrid-Guijarro Antonia , Garcés-Torres Ana Carolina
Published: December 2022

Open innovation (OI) has been appointed as a key factor to promote innovative performance, but some research gaps remain especially when it comes to SMEs in developing countries. This article deals with (1) the effect of formalization of innovation strategy on OI activities in SMEs, (2) the impact of OI activities on SMEs’ innovative performance, and (3) the moderating role played by control on the relationship between inbound and outbound activities and the innovative performance. OI encompasses a range of innovative methods and procedures in firms to stimulate internal innovation and widen the external use of innovation (inbound and outbound). In this work, an empirical study is carried out on 543 Ecuadorian SMEs. The results show that the formalization of the innovation strategy promotes OI activities, both inbound and outbound. While outbound activities carried out by SMEs enhance innovative performance, this positive effect is only identified for inbound open innovation activities when control exists and increases, acting this variable as a moderating factor. These results have important implications both for the management of companies and the development of public policies aimed at promoting OI in SMEs in developing countries. This research contributes to the literature as it deals with a developing country context and considers a wide range of OI activities.
Ideology Critique without Morality: A Radical Realist Approach
Authors: AYTAC UGUR , ROSSI ENZO
Published: December 2022

What is the point of ideology critique? Prominent Anglo-American philosophers recently proposed novel arguments for the view that ideology critique is moral critique, and ideologies are flawed insofar as they contribute to injustice or oppression. We criticize that view and make the case for an alternative and more empirically oriented approach, grounded in epistemic rather than moral commitments. We make two related claims: (a) ideology critique can debunk beliefs and practices by uncovering how, empirically, they are produced by self-justifying power and (b) the self-justification of power should be understood as an epistemic rather than moral flaw. Drawing on the recent realist revival in political theory, we argue that this genealogical approach has more radical potential, despite being more parsimonious than morality-based approaches. We demonstrate the relative advantages of our view by discussing the results of empirical studies on the contemporary phenomenon of neopatriarchy in the Middle East and North Africa.
Military Artificial Intelligence and the Principle of Distinction: A State Responsibility Perspective
Authors: Pacholska Magdalena
Published: December 2022

Military artificial intelligence (AI)-enabled technology might still be in the relatively fledgling stages but the debate on how to regulate its use is already in full swing. Much of the discussion revolves around autonomous weapons systems (AWS) and the ‘responsibility gap’ they would ostensibly produce. This contribution argues that while some military AI technologies may indeed cause a range of conceptual hurdles in the realm of individual responsibility, they do not raise any unique issues under the law of state responsibility. The following analysis considers the latter regime and maps out crucial junctions in applying it to potential violations of the cornerstone of international humanitarian law (IHL) – the principle of distinction – resulting from the use of AI-enabled military technologies. It reveals that any challenges in ascribing responsibility in cases involving AWS would not be caused by the incorporation of AI, but stem from pre-existing systemic shortcomings of IHL and the unclear reverberations of mistakes thereunder. The article reiterates that state responsibility for the effects of AWS deployment is always retained through the commander's ultimate responsibility to authorise weapon deployment in accordance with IHL. It is proposed, however, that should the so-called fully autonomous weapon systems – that is, machine learning-based lethal systems that are capable of changing their own rules of operation beyond a predetermined framework – ever be fielded, it might be fairer to attribute their conduct to the fielding state, by conceptualising them as state agents, and treat them akin to state organs.
Child Labour in Artisanal and Small-Scale Gold Mines in Uganda: Are Legal Protections Adequate?
Authors: Njieassam Esther
Published: December 2022

Child labour is prevalent in both developed and developing countries and has become a global concern. This is because of the negative impacts that it has not only on the human rights and fundamental freedoms of children, but on their development and health due to possible exposure to hazardous substances. This article interrogates the magnitude of the problem of child labour in the gold mines of Uganda and seeks to highlight the gaps in the existing legal framework on the protection of Ugandan children from hazardous labour. It asserts that although poverty and a failed educational system are believed to be the root causes of child labour in Uganda, weak and inefficient laws coupled with a lack of coordination between institutions responsible for protecting the child contribute equally. Thus there is need for political will by the government of Uganda to help prevent the problem.
Milk yield and composition in dairy goats fed extruded flaxseed or a high-palmitic acid fat supplement
Authors: Lévesque Janie , Dion Stéphanie , Rico Daniel E. , Brassard Marie-Ève , Gervais Rachel , Chouinard P. Yvan
Published: December 2022

We compared the potential of dietary lipid supplements of different fatty acid compositions to affect milk performance when early lactation dairy goats were fed a high-concentrate diet. Thirty Alpine goats at 23 ± 5 d in milk were allocated to 1 of 10 blocks according to parity and milk fat concentration. Within each block, goats were randomly assigned to receive, during a period of 41 d, either CONT) a basal diet with a forage to concentrate ratio of 45:55, used as control, or PALM) the basal diet + 2% of a palmitic acid-enriched fat supplement, or FLAX) the basal diet + 7% of extruded flaxseed. Body weight, dry matter intake and milk yield were not different between treatments. As compared with CONT, goats fed PALM and FLAX had a greater milk fat concentration. Moreover, milk fat yield was numerically (but non-significantly) greater with PALM than with CONT. Milk fat from goats receiving PALM had a greater concentration of 16:0 as compared with CONT and FLAX, whereas a greater concentration of cis-9, cis-12, cis-15 18:3 was observed when goats were fed FLAX as compared with CONT and PALM. Under the conditions of the current experiment, dietary fat supplementation had only minor impacts on the yield of major milk constituents, with the exception of a modest increase in fat yield when goats were fed PALM. The impact of a greater concentration of 16:0 in milk fat of goats receiving this feed ingredient on the nutritive value of dairy products remains to be determined.
On the nature of morphological alternations in Archaic Chinese and their relevance to morphosyntax
Authors: Jacques Guillaume
Published: December 2022

While sound glosses from the Six Dynasties and early Tang provide direct evidence for morphological alternations in Archaic Chinese, studies on the syntax of this language generally disregard these data. This neglect is due in part to perceived unreliability of these sound glosses. In this paper, I first argue that the arguments against their reliability do not stand scrutiny, and that they are not a simple philological curiosity, but have the potential to enrich studies on Archaic Chinese syntax, and plead for more collaboration between syntacticians and historical phonologists.
Is the assumption of waning of treatment effect applied consistently across NICE technology appraisals? A case-study focusing on disease-modifying therapies for treatment of multiple sclerosis
Authors: Armoiry Xavier , Wang-Steverding Xia , Connock Martin , Grove Amy , Clarke Aileen , Arun Tarunya , Counsell Carl , Auguste Peter
Published: December 2022

Objectives

Whether the effects of therapies may wane over time is a matter of debate, especially when considering their long-term cost-effectiveness. Here, we examined how the assumption of the waning of treatment effect was applied across the National Institute for Health and Care Excellence (NICE) appraisals for disease-modifying therapies (DMTs) used in multiple sclerosis.

Methods

We undertook a document analysis following a search of the NICE website. The inclusion criteria of the study were as follows: all publicly available documents related to completed appraisals for DMTs (period: January 2000 to July 2021). The exclusion criteria of the study were as follows: all documents that did not meet the inclusion criteria, especially pertaining to drugs used in other disease areas. We extracted information about the waning of treatment effect assumption as considered by companies, assessment groups, and appraisal committees, and we analyzed trends over time.

Results

We reviewed fifteen appraisals that reported guidance on sixteen DMTs. Irrespective of the drugs’ mechanism of action or their pharmaceutical nature, there was substantial variation in the modalities when the assumption of waning was implemented. We noted the recent preference to use all-cause discontinuation as a proxy. This heterogeneity did not appear to affect acceptance of the DMTs (all but one were recommended for use across the National Health System (NHS)).

Conclusions

Modeling the long-term effect of therapies is challenging, especially given the limited follow-up duration of related trials. This generates recurrent debates on the presence of waning of treatment efficacy and heterogeneity across appraisals. More refined recommendations obtained by consensus among stakeholders could help to achieve greater consistency in decision making.
Incorporating environmental and sustainability considerations into health technology assessment and clinical and public health guidelines: a scoping review
Authors: Pinho-Gomes Ana-Catarina , Yoo Seo-Hyun , Allen Alexander , Maiden Hannah , Shah Koonal , Toolan Michael
Published: December 2022

Healthcare systems account for a substantial proportion of global carbon emissions and contribute to wider environmental degradation. This scoping review aimed to summarize the evidence currently available on incorporation of environmental and sustainability considerations into health technology assessments (HTAs) and guidelines to support the National In stitute for Health and Care Excellence and analogous bodies in other jurisdictions developing theirown methods and processes. Overall, 7,653 articles were identified, of which 24 were included in this review and split into three key areas – HTA (10 studies), healthcare guidelines (4 studies), and food and dietary guidelines (10 studies). Methodological reviews discussed the pros and cons of different approaches to integrate environmental considerations into HTAs, including adjustments to conventional cost-utility analysis (CUA), cost–benefit analysis, and multicriteria decision analysis. The case studies illustrated the challenges of putting this into practice, such as lack of disaggregated data to evaluate the impact of single technologies and difficulty in conducting thorough life cycle assessments that consider the full environmental effects. Evidence was scant on the incorporation of environmental impacts in clinical practice and public health guidelines. Food and dietary guidelines used adapted CUA based on life cycle assessments, simulation modeling, and qualitative judgments made by expert panels. There is uncertainty on how HTA and guideline committees will handle trade-offs between health and environment, especially when balancing environmental harms that fall largely on society with health benefits for individuals. Further research is warranted to enable integration of environmental considerations into HTA and clinical and public health guidelines.
Sign advantage: Both children and adults’ spatial expressions in sign are more informative than those in speech and gestures combined
Authors: KARADÖLLER Dilay Z. , SÜMER Beyza , ÜNAL Ercenur , ÖZYÜREK Aslı
Published: December 2022

Expressing Left-Right relations is challenging for speaking-children. Yet, this challenge was absent for signing-children, possibly due to iconicity in the visual-spatial modality of expression. We investigate whether there is also a modality advantage when speaking-children’s co-speech gestures are considered. Eight-year-old child and adult hearing monolingual Turkish speakers and deaf signers of Turkish-Sign-Language described pictures of objects in various spatial relations. Descriptions were coded for informativeness in speech, sign, and speech-gesture combinations for encoding Left-Right relations. The use of co-speech gestures increased the informativeness of speakers’ spatial expressions compared to speech-only. This pattern was more prominent for children than adults. However, signing-adults and children were more informative than child and adult speakers even when co-speech gestures were considered. Thus, both speaking- and signing-children benefit from iconic expressions in visual modality. Finally, in each modality, children were less informative than adults, pointing to the challenge of this spatial domain in development.
Concurrent validity and reliability of at-home teleneuropsychological evaluations among people with and without HIV
Authors: Kohli Maulika , Fisher Arin , Sun-Suslow Ni , Heaton Anne , Dawson Matthew S. , Marquie Jennifer , Franklin Donald R. , Marquine Maria , Iudicello Jennifer E. , Heaton Robert K. , Moore David J.
Published: December 2022

Objective:

To determine the reliability of teleneuropsychological (TNP) compared to in-person assessments (IPA) in people with HIV (PWH) and without HIV (HIV−).

Methods:

Participants included 80 PWH (Mage = 58.7, SDage = 11.0) and 23 HIV− (Mage = 61.9, SDage = 16.7). Participants completed two comprehensive neuropsychological IPA before one TNP during the COVID-19 pandemic (March–December 2020). The neuropsychological tests included: Hopkins Verbal Learning Test-Revised (HVLT-R Total and Delayed Recall), Controlled Oral Word Association Test (COWAT; FAS-English or PMR-Spanish), Animal Fluency, Action (Verb) Fluency, Wechsler Adult Intelligence Scale 3rd Edition (WAIS-III) Symbol Search and Letter Number Sequencing, Stroop Color and Word Test, Paced Auditory Serial Addition Test (Channel 1), and Boston Naming Test. Total raw scores and sub-scores were used in analyses. In the total sample and by HIV status, test-retest reliability and performance-level differences were evaluated between the two consecutive IPA (i.e., IPA1 and IPA2), and mean in-person scores (IPA-M), and TNP.

Results:

There were statistically significant test-retest correlations between IPA1 and IPA2 (r or ρ = .603–.883, ps < .001), and between IPA-M and TNP (r or ρ = .622–.958, ps < .001). In the total sample, significantly lower test-retest scores were found between IPA-M and TNP on the COWAT (PMR), Stroop Color and Word Test, WAIS-III Letter Number Sequencing, and HVLT-R Total Recall (ps < .05). Results were similar in PWH only.

Conclusions:

This study demonstrates reliability of TNP in PWH and HIV−. TNP assessments are a promising way to improve access to traditional neuropsychological services and maintain ongoing clinical research studies during the COVID-19 pandemic.
EU Law’s Dark Private Legal Space: Researching Private Regulators and the Importance of Legal Doctrine
Authors: Beckers Anna
Published: December 2022

Private actors as non-institutional, and therefore often overlooked, participants in EU legal processes – A specific focus on their role as private regulators – Private actors such as companies, contracting parties and industry associations, play a pivotal regulatory role in the EU legal order – Classifying the existing legal research on private regulation – A legal-doctrinal approach towards private regulation also needed – Theoretical background of a novel legal-doctrinal perspective on private actors – Addressing the most pressing practical methodological challenges – Specific focus on the problem of accessibility and the difficulty of understanding and interpreting private regulation doctrinally
The Foundations of EU Administrative Law as a Scholarly Field: Functional Comparison, Normativism and Integration
Authors: Mendes Joana
Published: December 2022

Functional comparison of administrative laws – Development of EU administrative law based on a state-matrix of general principles – Jürgen Schwarze’s approach – Choices of object, objectives, method, assumptions and normative implications – Structural features of the EU administration versus the binary liberty-authority of core principles of national administrative law – Liberal normativist approach – Contemporary critical examination of the legacy of comparative administrative law
The Italian consensus conference on psychological therapies for anxiety and depressive disorders: findings and recommendations
Authors: Barbato Angelo , Bottesi Gioia , Biondi Massimo , Corbo Mariangela , de Girolamo Giovanni , Favaretto Gerardo , Garattini Silvio , Migone Paolo , Moderato Paolo , Monzani Emiliano , Veltro Franco , Sanavio Ezio
Published: December 2022

A Consensus Conference of clinicians, researchers, public health specialists and users was convened in Italy to review efficacy, effectiveness, treatment appropriateness and access to care for anxiety and depression, and to consider the role of psychological therapies. Expert opinion was sought concerning identification of people requiring psychological therapies according to levels of symptom severity matched to corresponding levels of treatment intensity, suitability of psychological therapies for subclinical anxiety or depression, definition of a minimum level of information on evidence-based psychotherapies to be provided by university medical and psychology courses, initiatives to raise awareness among potential users and decision makers on the role and effectiveness of psychological therapies in healthcare. The expert jury concluded that a number of psychological therapy models endorsed by most authoritative guidelines are supported by research showing their effectiveness at least equal to the drugs used in common mental disorders (CMDs). Such therapies are under-represented in the Italian public health system, leading many people to resort to the private sector, resulting in unacceptable wealth discrimination. The difficulty of accessing psychological treatments often entails the use of drug therapies in cases where they are not indicated. Starting from these assumptions, the experts recommended the promotion of better and timely recognition of anxiety and depressive disorders and their classification in terms of symptom intensity and functional impairment, differentiating subthreshold mood swings from clinical forms, to foster outcome studies of psychotherapies in CMDs in Italy, to introduce a stepped care model structured according to levels of intensity of treatment, based on wellbeing support strategies in nonmedical contexts for subthreshold situations, self-help, support and psychoeducation as frontline interventions in mild clinical forms, evidence-based psychotherapies in moderate and severe forms, with the option of combining psychological treatment and appropriate drug therapy in the most severe cases.
Preclinical and clinical evidence on the approach-avoidance conflict evaluation as an integrative tool for psychopathology
Authors: Rusconi F. , Rossetti M. G. , Forastieri C. , Tritto V. , Bellani M. , Battaglioli E.
Published: December 2022

The approach-avoidance conflict (AAC), i.e. the competing tendencies to undertake goal-directed actions or to withdraw from everyday life challenges, stands at the basis of humans' existence defining behavioural and personality domains. Gray's Reinforcement Sensitivity Theory posits that a stable bias toward approach or avoidance represents a psychopathological trait associated with excessive sensitivity to reward or punishment. Optogenetic studies in rodents and imaging studies in humans associated with cross-species AAC paradigms granted new emphasis to the hippocampus as a hub of behavioural inhibition. For instance, recent functional neuroimaging studies show that functional brain activity in the human hippocampus correlates with threat perception and seems to underlie passive avoidance. Therefore, our commentary aims to (i) discuss the inhibitory role of the hippocampus in approach-related behaviours and (ii) promote the integration of functional neuroimaging with cross-species AAC paradigms as a means of diagnostic, therapeutic, follow up and prognosis refinement in psychiatric populations.
GRIEF, GRIEVING, AND LOSS IN HIGH MEDIEVAL HISTORICAL THOUGHT
Authors: WINKLER EMILY A.
Published: December 2022

This article investigates how and why medieval ecclesiastical writers thought and wrote about experiences of grief in human history. It examines the works of three late twelfth-century Latin writers from England: a foundation history of Waltham Abbey and its holy cross, a series of annals kept by Hugh Candidus at Peterborough, and Gerald of Wales's autobiographical and travel writing alongside his De principis instructione. Drawing on biblical, literary, theological, and iconographic models for grief and suffering in the western Christian tradition, the article situates these works in the exegetical and philosophical ideas they shared, and explains what is original and significant about their approaches to each instance of grief. It argues that the central problem these writers pondered in their narratives was the relationship between the universal and particular nature of grief. Grieving, they thought, had three key qualities: it impelled a desire to act; it could not be meaningfully measured; and it persisted in time. In prioritizing the experience of grief over its function, meaning, or morality, these writers considered the emotion rational, natural, and honest. The value these writers placed on human family or family-like relationships provides the context for understanding their priorities in thinking about responses to loss. Interest in grief's endurance, rather than its resolution in consolation, has been understood as more typical of secular, not sacred, thought. By showing how these writers’ ideas about grief's nature lived alongside and within other ideas of Christian thought, this article illuminates a greater range of medieval ecclesiastical ideas about the dignity of human history and emotion.
Psychophysiological Stress Response of Novel Students in Chemical Laboratory Practices
Authors: Redondo-Flórez Laura , Clemente-Suárez Vicente Javier
Published: December 2022

Abstract: The aim of the present study was to analyze the psychophysiological stress response of novel pharmacy and biotechnology students in chemistry laboratory practices. Autonomic stress response was analyzed in 66 students by considering heart rate variability (HRV) values before, during, and after their first laboratory practice, as well as their distress perception before and after this activity. In the laboratory practice, students had to deal with toxic products, sharp objects, or irritating substances while being examined by the teachers. Consistent with a large anticipatory anxiety response at the beginning of the practice, results showed low HRV values, generally related to a typical sympathetic modulation. This sympathetic effect persisted during the entire laboratory practice. Moreover, just after the end of the practice, there was an attenuation of the sympathetic activation and a takeover by the parasympathetic system, as revealed by the increase of HRV parameters. Laboratory practices performed by novel Pharmacy and Biotechnology students did not produce the expected habituation response at psychophysiological level since, in addition to an anticipatory anxiety response observed prior to the laboratory practice, a high sympathetic autonomic activation was observed during the whole practice. In brief, using HRV parameters could be a useful tool to analyze stress responses in students and to help them with new strategies to improve routine evaluation procedures.
Science Denial
Authors: Jylhä Kirsti M. , Stanley Samantha K. , Ojala Maria , Clarke Edward J. R.
Published: December 2022

Abstract: Science denial has adverse consequences at individual and societal levels and even for the future of our planet. The present article aimed to answer the question: What leads people to deny even the strongest evidence and distrust the scientific method? The article provides a narrative review of research on the underpinnings of science denial, with the main focus on climate change denial. Perspectives that are commonly studied separately are integrated. We review key findings on the roles of disinformation and basic cognitive processes, motivated reasoning (focusing on ideology and populism), and emotion regulation in potentially shaping (or not shaping) views on science and scientific topics. We also include research on youth, a group in an important transition phase in life that is the future decision-makers but less commonly focused on in the research field. In sum, we describe how the manifestations of denial can stem from cognitive biases, motivating efforts to find seemingly rational support for desirable conclusions, or attempts to regulate emotions when feeling threatened or powerless. To foster future research agendas and mindful applications of the results, we identify some research gaps (most importantly related to cross-cultural considerations) and examine the unique features or science denial as an object of psychological research. Based on the review, we make recommendations on measurement, science communication, and education.
Global Gridded Ionospheric Electron Density Derivation During 2006–2016 by Assimilating COSMIC TEC and Its Validation
Authors: He Jianhui , Yue Xinan , Astafyeva Elvira , Le Huijun , Ren Zhipeng , Pedatella Nicholas M. , Ding Feng , Wei Yong
Published: December 2022

The long‐term accurate specification of the Earth's ionospheric states is crucial to scientific research and applications in the space weather community. In the current work, a global monthly mean three‐dimensional (3‐D) ionospheric electron density product has been obtained during one solar cycle from 2006 to 2016. Specifically, an accurate 3‐D product is reconstructed monthly by assimilating the Constellation Observing System for Meteorology, Ionosphere and Climate slant total electron content (TEC) into an empirical background model via the Kalman filter data assimilation algorithm. The outputs of the results have spatial resolutions of 2° in latitude, 5° in longitude, and 20 km in height, and temporal resolution of 1 hr in universal time. The accuracy and reliability of the results are systematically validated by the critical frequency at the F2 layer from global ionosonde stations, the in situ electron density from the CHAllenging Minisatellite Payload Planar Langmuir Probe, the TEC from the Massachusetts Institute of Technology, and Gravity Recovery and Climate Experiment. We found that the products agree well with the independent observations. Some well‐known ionospheric climatological patterns, including the solar and seasonal variation, annual asymmetry, the Weddell Sea Anomaly, and the longitudinal wave structure, can be well illustrated. The advantages of the products are its 3‐D and gridded electron density and continuous one solar cycle time series (2006–2016). It is useful to study the spatial‐temporal variations in ionospheric states from seasons to decades, which can also be used as the background parameters for atmospheric and ionospheric‐related scientific research and applications.