bluuebunny/crossref_metadata_2025 huggingface dataset:
Going Retro, Going Viral: Experiences and Lessons in Drug Discovery from COVID-19
Authors: Wang Bing , Svetlov Dmitri , Bartikofsky Dylan , Wobus Christiane E. , Artsimovitch Irina
Published: June 2022

The severity of the COVID-19 pandemic and the pace of its global spread have motivated researchers to opt for repurposing existing drugs against SARS-CoV-2 rather than discover or develop novel ones. For reasons of speed, throughput, and cost-effectiveness, virtual screening campaigns, relying heavily on in silico docking, have dominated published reports. A particular focus as a drug target has been the principal active site (i.e., RNA synthesis) of RNA-dependent RNA polymerase (RdRp), despite the existence of a second, and also indispensable, active site in the same enzyme. Here we report the results of our experimental interrogation of several small-molecule inhibitors, including natural products proposed to be effective by in silico studies. Notably, we find that two antibiotics in clinical use, fidaxomicin and rifabutin, inhibit RNA synthesis by SARS-CoV-2 RdRp in vitro and inhibit viral replication in cell culture. However, our mutagenesis studies contradict the binding sites predicted computationally. We discuss the implications of these and other findings for computational studies predicting the binding of ligands to large and flexible protein complexes and therefore for drug discovery or repurposing efforts utilizing such studies. Finally, we suggest several improvements on such efforts ongoing against SARS-CoV-2 and future pathogens as they arise.
The Agronomic Traits, Alkaloids Analysis, FT-IR and 2DCOS-IR Spectroscopy Identification of the Low-Nicotine-Content Nontransgenic Tobacco Edited by CRISPR–Cas9
Authors: Zhang Jianduo , Zhou Qun , Zhang Dongheyu , Yang Guangyu , Zhang Chengming , Wu Yuping , Xu Yong , Chen Jianhua , Kong Weisong , Kong Guanghui , Wang Jin
Published: June 2022

In this study, the agricultural traits, alkaloids content and Fourier transform infrared spectroscopy (FT-IR) and two-dimensional correlation infrared spectroscopy (2DCOS-IR) analysis of the tobacco after Berberine Bridge Enzyme-Like Proteins (BBLs) knockout were investigated. The knockout of BBLs has limited effect on tobacco agricultural traits. After the BBLs knockout, nicotine and most alkaloids are significantly reduced, but the content of myosmine and its derivatives increases dramatically. In order to identify the gene editing of tobacco, principal component analysis (PCA) was performed on the FT-IR and 2DCOS-IR spectroscopy data. The results showed that FT-IR can distinguish between tobacco roots and leaves but cannot classify the gene mutation tobacco from the wild one. 2DCOS-IR can enhance the characteristics of the samples due to the increased apparent resolution of the spectra. Using the autopeaks in the synchronous map for PCA analysis, we successfully identified the mutants with an accuracy of over 90%.
Ascorbate as a Bioactive Compound in Cancer Therapy: The Old Classic Strikes Back
Authors: González-Montero Jaime , Chichiarelli Silvia , Eufemi Margherita , Altieri Fabio , Saso Luciano , Rodrigo Ramón
Published: June 2022

Cancer is a disease of high mortality, and its prevalence has increased steadily in the last few years. However, during the last decade, the development of modern chemotherapy schemes, new radiotherapy techniques, targeted therapies and immunotherapy has brought new hope in the treatment of these diseases. Unfortunately, cancer therapies are also associated with frequent and, sometimes, severe adverse events. Ascorbate (ascorbic acid or vitamin C) is a potent water-soluble antioxidant that is produced in most mammals but is not synthesised endogenously in humans, which lack enzymes for its synthesis. Ascorbate has antioxidant effects that correspond closely to the dose administered. Interestingly, this natural antioxidant induces oxidative stress when given intravenously at a high dose, a paradoxical effect due to its interactions with iron. Importantly, this deleterious property of ascorbate can result in increased cell death. Although, historically, ascorbate has been reported to exhibit anti-tumour properties, this effect has been questioned due to the lack of available mechanistic detail. Recently, new evidence has emerged implicating ferroptosis in several types of oxidative stress-mediated cell death, such as those associated with ischemia–reperfusion. This effect could be positively modulated by the interaction of iron and high ascorbate dosing, particularly in cell systems having a high mitotic index. In addition, it has been reported that ascorbate may behave as an adjuvant of favourable anti-tumour effects in cancer therapies such as radiotherapy, radio-chemotherapy, chemotherapy, immunotherapy, or even in monotherapy, as it facilitates tumour cell death through the generation of reactive oxygen species and ferroptosis. In this review, we provide evidence supporting the view that ascorbate should be revisited to develop novel, safe strategies in the treatment of cancer to achieve their application in human medicine.
Correction: Mikołajczyk et al. Nucleophilic Substitution at Heteroatoms—Identity Substitution Reactions at Phosphorus and Sulfur Centers: Do They Proceed in a Concerted (SN2) or Stepwise (A–E) Way? Molecules 2022, 27, 599
Authors: Mikołajczyk Marian , Cypryk Marek , Gostyński Bartłomiej , Kowalczewski Jakub
Published: June 2022

(1) The authors would like to correct mistakes in the title paper [...]
Protective Effects of Liquiritigenin against Cisplatin-Induced Nephrotoxicity via NRF2/SIRT3-Mediated Improvement of Mitochondrial Function
Authors: Zhou Meng , Dai Yanpeng , Ma Yong , Yan Yi , Hua Min , Gao Qi , Geng Xue , Zhou Qian
Published: June 2022

Acute kidney injury (AKI) induced by cisplatin (CP), a first-line anticancer drug for chemotherapy, is common. To date, there is an urgent need to find effective treatments to reduce the nephrotoxicity caused by CP. Meanwhile, the restoration of mitochondrial dysfunction shows potential to be used as an adjunct to conventional therapeutic strategies. This study found that liquiritigenin can ameliorate mitochondrial dysfunction and acute kidney injury induced by CP in mice. The intraperitoneal injection of 15 mg/kg body weight liquiritigenin for 2 days markedly protected against CP-induced mitochondrial dysfunction, restored renal tubule and mitochondrial morphology, decreased blood Scr and BUN levels, and decreased cell apoptosis. Furthermore, the elevated expression of SIRT3 induced by liquiritigenin, which can be upregulated by NRF2, was confirmed in vivo and in vitro. The underlying protective mechanisms of liquiritigenin in CP-induced nephrotoxicity were then investigated. Molecular docking results showed that liquiritigenin has potent binding activities to KEAP1, GSK-3β and HRD1. Further results showed that liquiritigenin induced the nuclear translocation of NRF2 and increased the levels of mitochondrial bioenergetics-related protein such as PGC-1α, and TFAM, which are related to NRF2 activity and mitochondrial biogenesis. In addition, liquiritigenin was found to possibly reverse the decrease in BCL2/BAX ratio induced by CP in live cultured renal tubule epithelial cells. Collectively, these results indicated that liquiritigenin could be used as a potential nephroprotective agent to protect against cisplatin-induced acute kidney injury in a NRF2-dependent manner by improving mitochondria function.
RETRACTED: Artemisia Extracts and Artemisinin-Based Antimalarials for COVID-19 Management: Could These Be Effective Antivirals for COVID-19 Treatment?
Authors: Agrawal Pawan , Agrawal Chandan , Blunden Gerald
Published: June 2022

As the world desperately searches for ways to treat the coronavirus disease 2019 (COVID-19) pandemic, a growing number of people are turning to herbal remedies. The Artemisia species, such as A. annua and A. afra, in particular, exhibit positive effects against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and COVID-19 related symptoms. A. annua is a source of artemisinin, which is active against malaria, and also exhibits potential for other diseases. This has increased interest in artemisinin’s potential for drug repurposing. Artemisinin-based combination therapies, so-called ACTs, have already been recognized as first-line treatments against malaria. Artemisia extract, as well as ACTs, have demonstrated inhibition of SARS-CoV-2. Artemisinin and its derivatives have also shown anti-inflammatory effects, including inhibition of interleukin-6 (IL-6) that plays a key role in the development of severe COVID-19. There is now sufficient evidence in the literature to suggest the effectiveness of Artemisia, its constituents and/or artemisinin derivatives, to fight against the SARS-CoV-2 infection by inhibiting its invasion, and replication, as well as reducing oxidative stress and inflammation, and mitigating lung damage.
Assessment and Remediation of Soils Contaminated by Potentially Toxic Elements (PTE)
Authors: Spagnuolo Matteo , Adamo Paola , Garau Giovanni
Published: June 2022

Potentially toxic elements (PTE) can cause significant damage to the environment and human health in the functions of mobility and bioavailability [...]
Implementation of Improvements Based on the Analysis of Severe Adverse Events in Pediatric Patients
Authors: Bigio Cecilia , Rodrigues Marcia , de Melo Carolina , Isoppo Catherine , Hoffmeister Louíse
Published: June 2022

Introduction: Health systems currently present a great degree of complexity, which provides risks to patients related to healthcare, and the possibility of incidents with or without harm. Patient safety culture highlights the need to investigate, analyze, and mitigate incidents to reduce risks to the patient. Medication errors have a high potential to do harm in pediatric hospital routines and most of them are preventable. The objective of this study was to describe a severe drug-related adverse event and present the root cause analysis and implemented improvements.

Methods: A 3-month-old patient undergoing therapeutic cardiac catheterization at another hospital presented with cardiorespiratory arrest in post-procedure progression after returning to the hospital of origin; this was a case of adverse events with medication use in pediatrics. Root cause analysis was performed using the London Protocol. Brainstorming was conducted to study the main improvements to be proposed to the institution.

Results: Improvements were identified and implemented in various processes, such as patient transport, drug dispensing, and administration. Root cause analysis made it possible to select the processes and departments involved and detect possible factors related to the adverse event. These changes were monitored, and after five years the indicators show that they have become consolidated.

Conclusions: The explanation of this event shows how a hospital service can review workflows and processes and implement improvements to reduce risks and prevent further damage through the analysis of an adverse event.
Postoperative Pneumonia Prevention Checklist Improves Provider Compliance and Patient Awareness of Previously Established Reduction Protocol
Authors: Lamm Ryan , Creisher Brandon , Curran John , Munden Emily , Williamson John , Schleider Christine , Shindle Kathleen , Cowan Scott , Lavu Harish , Costanzo Caitlyn
Published: June 2022

Background: Postoperative pneumonia (PoPNA) is a highly prevalent complication in patients. Despite a previously successful protocol, this institution has become a high outlier on national metrics for PoPNA in the last four years.

Methods: Between October 2020 and May 2021, patients were surveyed to measure 10 initiatives which have shown previous success. A provider-driven 10-item checklist was implemented and patients were resurveyed.

Results: 135 patients were included: 96 pre-checklist and 39 post-checklist. Improvement was seen in all 10 categories. This included provider-driven initiatives, such as patient oral care, ambulation, frequency of patient being in chair, having incentive spirometer (IS) within reach, having information booklet within reach, and the patient’s ability to perform IS correctly, as well as patient awareness initiatives, including importance of oral care, cough and deep breathing, ambulation, and IS use.

Conclusions: Implementation of a simple checklist can improve awareness and compliance with previously successful established protocols.
Alfabetización digital desde la perspectiva del directivo de escuela pública: una revisión bibliográfica
Authors: Sotelo Espinoza Mariela Milagritos , Gastello Mathews Willy
Published: June 2022

La presente investigación tuvo como objetivo determinar las características de la alfabetización digital desde la perspectiva del directivo de escuela pública. Se efectuó un estudio bibliográfico obteniendo información de Scopus, Ebsco, Scielo, Dialnet y Google Académico. Los resultados muestran la importancia de contar con competencias acerca de alfabetización digital, también muestra la resistencia que presentan algunos estudiantes en el uso de las herramientas digitales, del mismo modo sucede con los maestros tradicionales. De tal manera que se concluye que la alfabetización digital trae consigo ventajas importantes a las personas que alcanzan esta habilidad, aspecto que va a contribuir a tener acceso a ingente información en el ciber espacio y a participar en las decisiones con sus aportes en los planes de las instituciones del Estado.
The Role of Dihydroresveratrol in Enhancing the Synergistic Effect of
Ligilactobacillus salivarius
Li01 and Resveratrol in Ameliorating Colitis in Mice
Authors: Fei Yiqiu , Zhang Shuobo , Han Shengyi , Qiu Bo , Lu Yanmeng , Huang Weixing , Li Fang , Chen Deying , Berglund Björn , Xiao Hang , Li Lanjuan , Yao Mingfei
Published: June 2022

Currently approved therapeutical strategies for inflammatory bowel diseases (IBD) suffer from variable efficacy and association with risk of serious side effects. Therefore, efforts have been made in searching for alternative therapeutics strategies utilizing gut microbiota manipulation. In this study, we show that the probiotic strain
Ligilactobacillus salivarius
Li01 (Li01) and the phytochemical prebiotic resveratrol (RSV) have synergistic effect in ameliorating colitis in mice. Oral coadministration of Li01 (10
9
 CFU/d) and RSV (1.5 g/kg/d) promoted restoration of various inflammatory injuries and gut microbiota composition, exhibiting a favorable anti-inflammatory effect in DSS-induced colitis mice. The combination treatment was associated with reductions in the levels of proinflammatory cytokines IL-1
β
and IL-6 and increases in the levels of the anti-inflammatory cytokine IL-17A in mouse serum. Moreover, the combination treatment was found to alter the composition and metabolism of the gut microbiota, especially influencing the production of short chain fatty acids and anti-inflammatory related molecules. The mechanism underlying the improved anti-inflammatory effect from the RSV and Li01 combination treatment was found to be associated with the environmental sensor mammalian aryl hydrocarbon receptor (AHR) and tryptophan metabolism pathway. Administration of RSV in combination with Li01 in different mouse model led to enhanced conversion of RSV into metabolites, including dihydroresveratrol (DHR), resveratrol-sulfate, and resveratrol-glucuronide. DHR was found to be the dominant metabolite of RSV in conventional and colitis mice. An increased DHR/RSV ratio was confirmed to activate AHR and contribute to an enhanced anti-inflammatory effect. DHR is considered as a potential AHR ligand. The DHR/RSV ratio also affected the serotonin pathway by controlling the expression of Tph1, SERT, and 5-HT
7
R leading to amelioration of colitis in mice. Our data suggest that treatment with a combination of Li01 and RSV has potential as a therapeutic strategy for IBD; further investigation of this combination in clinical settings is warranted.
EXAMINING STUDENTS’ BEHAVIORAL USE OF CAMPUS JOURNAL WITH THE TECHNOLOGY ACCEPTANCE MODEL APPROACH
Authors: Sani Asrul , Wibawa Agus Pratama , Aisyah Siti , Supit Merliani Ivone , Budiyantara Agus
Published: June 2022

Student behaviour is an activity carried out by students for each individual. Students who visit campus journal websites are essential in terms of journal accreditation aspects, where this is a benchmark for increasing the journal's potential as a reference. However, some factors influence it where the frequency of students visiting campus journal websites is not as expected in exploring journals, and the enthusiasm of students to download articles is still below the desired expectations. This causes the potential for the journal to obtain national accreditation at a small percentage, and students may think that there are very few reference sources for journals, so it is less attractive on the campus journal website system. Data collection methods were used in this study, such as interviews, literature study, and questionnaires. Meanwhile, to evaluate the campus journal website system on student behaviour using the Technology Acceptance Model (TAM) with four variables: perceived ease of use, perceived usefulness, attitude toward using, and behavioural intention to use. This method makes the user feel it is easier to access the campus journal website; then, the user feels the campus journal website can provide benefits and usability. The user has a great curiosity to access the campus journal, and finally, the user wants to access the website and take the initiative to influence. other users in to access the same
ESTRUCTURA Y DIFERENCIACIÓN GENÉTICA DE POBLACIONES SILVESTRES Y DOMESTICADAS DE CHILE DEL NOROESTE DE MÉXICO ANALIZADA CON ISOENZIMAS Y RAPDs
Authors: Hernández-Verdugo Sergio , González-Rodríguez Antonio , Sánchez-Peña Pedro , Casas Alejandro , Oyama Ken
Published: June 2022

Se determinó la estructura y variación genética de 18 poblaciones silvestres y tres domesticadas de chile (Capsicum annuum L.) del noroeste de México con isoenzimas y RAPDs. El análisis con isoenzimas se basó en 12 loci polimórficos de nueve isoenzimas. Todas las poblaciones mostraron altos niveles de variación genética (A = 2.72, P = 90.8 %, He = 0.445 para las poblaciones silvestres; y A = 2.60, P = 84.6 %, He = 0.404, para las poblaciones domesticadas). La mayor proporción de la variación genética se encontró dentro, más que entre poblaciones. Sin embargo, la diferenciación fue mayor entre las poblaciones domesticadas (GST = 0.167) que entre las silvestres (GST = 0.056). El análisis con los RAPDs efectuado con diez iniciadores produjo un total de 166 bandas, todas polimórficas en las poblaciones silvestres. De 126 bandas 25 fueron polimórficas en las poblaciones domesticadas. El porcentaje de polimorfismo promedio fue 34.2 y 34.7 en las poblaciones silvestres y domesticadas, respectivamente. La diversidad genética promedio y total fue 0.069 y 0.165 para las poblaciones silvestres y 0.081 y 0.131 para las poblaciones domesticadas. El AMOVA mostró que la diversidad genética total fue distribuida igualmente entre (50.0 y 48.9 %) y dentro (50.0 y 51.1 %) de las poblaciones silvestres y domesticadas. Las poblaciones silvestres y domesticadas se separaron claramente en el dendrograma UPGMA construido con los datos de las isoenzimas (DG promedio = 0.182) y con el AMOVA (17.2 % de la varianza estuvo entre tipos de poblaciones, P ≤ 0.001). Las distancias genéticas considerables encontradas entre variedades (DG promedio = 0.212 con isoenzimas) sugiere que los cambios asociados con la domesticación han ocurrido en direcciones diferentes.
EFECTO DEL NÚMERO DE FRUTOS POR RACIMO Y FECHAS DE CORTE EN LA CALIDAD DE MANZANA ‘RAYADA’
Authors: Mendoza-López Alejandra A. , Kushad Mosbah , Zavala-Del Ángel Iván , Martínez-Peniche Ramón Álvar
Published: June 2022

La manzana (Malus domestica Borkh) producida en temporal o secano en la Sierra de Querétaro, México, se comercializa deficientemente debido a la baja calidad comercial de la fruta y a que madura cuando el mercado nacional se encuentra saturado de la misma. Sin embargo, existe en la región una variedad prometedora, de maduración temprana, localmente conocida como ‘Rayada’, cuyos frutos, al presentarse en gran número en los racimos, resultan de diámetro menor al comercial. En el presente trabajo se evaluó el efecto del número de frutos por racimo y de la época de cosecha sobre: peso y diámetro de la fruta, sólidos solubles totales (SST), acidez total titulable (ATT), la firmeza y concentración de calcio, de manzana ‘Rayada’ producida en la Sierra de Querétaro. Se estableció un experimento bifactorial en bloques al azar donde, en 10 árboles adultos seleccionados por su productividad e injertados sobre MM 111; se muestrearon frutos establecidos naturalmente de 1, 2, 3 y 4 por racimo, durante siete fechas de corte, con una semana de intervalo, a partir de junio 29. Con un fruto por racimo se obtuvo el mayor peso del mismo (102.6 g), diámetro ecuatorial (64.0 mm), y concentración de calcio (10.45 mg 100 g-1 PF). La mejor época para cosechar la manzana ‘Rayada’ en la Sierra de Querétaro fue a finales de julio y principios de agosto en que la fruta alcanzó el máximo tamaño (101.6 g, 64.4 mm) y la mayor relación entre SST/ATT (1.95). La fecha de corte no tuvo efecto directo en la firmeza ni en la concentración de calcio.
CRECIMIENTO DEL FRUTO DE ZAPOTE MAMEY [Pouteria sapota (Jacq.) H. E. Moore & Stearn] EN MORELOS, MÉXICO
Authors: Sandoval-Maruri Esther , Nieto-Ayala Emma , Alia-Tejacal Irán , López-Martínez Víctor , Colinas-León Ma. Teresa , Martínez-Morales Arturo , Acosta-Durán Carlos Manuel , Andrade-Rodríguez María , Villegas-Torres Óscar , Guillén-Sánchez Dagoberto
Published: June 2022

Se determinó el periodo de desarrollo del fruto de zapote mamey [Pouteria sapota (Jacq.) H. E. Moore & Stearn], así como su patrón de crecimiento mediante el diámetro polar y ecuatorial; también se definió el periodo donde ocurre la mayor abscisión de fruto y la distribución de la masa en las estructuras del mismo. El crecimiento del fruto de mamey desde flor a fruto fisiológicamente maduro, duró entre 18 y 20 meses, con un patrón de crecimiento sigmoidal. La mayor caída de frutos (76 %) se presentó cinco meses antes de la floración siguiente. En promedio, los frutos cosechados representaron 20 % del total inicial, y la cosecha fue en los meses de febrero a mayo. La masa del fruto se incrementò después del mes de abril en un patrón sigmoidal; 60 % de la masa se asignó a pulpa, 25 % a cáscara y 15 % a semilla, cerca de la cosecha.
REPERCUSIONES FÍSICAS Y FISIOLÓGICAS DEL ENVEJECIMIENTO NATURAL DE SEMILLAS DE CRUZAS SIMPLES DE MAÍZ Y SUS LÍNEAS PROGENITORAS
Authors: Fragoso-Pérez Elizabeth Madey , Gutiérrez-H. Germán F. , Virgen-Vargas Juan
Published: June 2022

Con la finalidad de detectar y cuantificar los daños causados por el envejecimiento natural sobre algunos eventos iniciales de la germinación, se hizo el análisis físico y fisiológico de semillas de dos edades (19 y 6 años), de dos cruzas simples de maíz y de sus líneas progenitoras. Las semillas estuvieron almacenadas sin control de temperatura ni humedad. Se usó un diseño de bloques al azar con dos repeticiones y 10 semillas como unidad experimental. En cada unidad se evaluó contenido de humedad, integridad del pericarpio, lixiviación de solutos, viabilidad y protrusión radicular. Los resultados indicaron que las variables físicas (contenido de humedad e integridad del pericarpio) permanecieron sin variaciones significativas durante los años de almacenamiento de las semillas; sin embargo, las fisiológicas (protrusión radicular y viabilidad) se afectaron (P ≤ 0.05) hasta hacerse nulas en semillas de mayor edad, en las cuales también el lixiviado de solutos fue más profuso (P ≤ 0.05). Se detectaron correlaciones significativas para viabilidad con protrusión radicular (0.98 **) y también con lixiviación de solutos (- 0.66 *), así como entre lixiviación de solutos y protrusión radicular (- 0.66 *).
PENGARUH LITERASI HALAL DAN RELIGIUSITAS TERHADAP MINAT KONSUMSI PRODUK HALAL MASYARAKAT KABUPATEN MADIUN
Authors: Setyowati Anis , Anwar Moch. Khoirul
Published: June 2022

Along with the increasing circulation of halal products on the Indonesian market, which causes an increase in public interest in consuming halal products, there are several influencing factors. This study will discuss the effect of halal literacy and religiosity on interest in consuming halal products, a case study of Madiun Regency. The method used is quantitative. The type of research data used is primary research data by distributing questionnaires in the form of Google Forms to the people of Madiun Regency with 100 respondents. Data processing to accurate results using instrument tests consisting of validity and reliability tests, classical assumption test, multiple linear regression analysis, t-test, f-test, and the coefficient of determination (R2) test. The results showed that halal literacy and religiosity partially and simultaneously influence the interest in consuming halal products in Madiun Regency for a contribution role of 42.8%.
Adoption of Digital Technology: Mapping the Important Roles in Current Agriculture Ecosystem Before & During Pandemic Covid 19 in West Java
Authors: Sulyani Agnesia Candra , Larasati Niken , Alyssa Nadya
Published: June 2022

Indonesia is the 4th most populous country in the world (Infoplease, 2021), and Indonesia is one of the world’s largest producers and exporters of agricultural crops (Statista, 2022). In 2019, FAO estimated that the agricultural area in Indonesia is around 62.300.000 ha (FAO, 2021). Around 60 percent of the total population is in Java island and Bali which are only about 7 percent of the total country’s area (FAO, nd). These islands are believed to be the most fertile of any other island in Indonesia. That’s why Indonesia is called an agrarian country. Indonesia's agriculture industry is a huge contributor to the Indonesian economy. More than 29 percent of the Indonesian workforce are working in agriculture. It is why agriculture become important to Indonesia. According to Indonesia Statistic Data (BPS, 2019), Agriculture in Indonesia contributes more than 13 percent, which is the third most biggest-contributor after manufacturing and trade. With this performance of Indonesia's agriculture, Indonesia has a great opportunity in the future to give a contribution to the food supply of the world. But according to Indonesia’s Statistic Data stated in The Jakarta Post, Indonesia already lost 5.1 million farmers between 2003 and 2013 (The Jakarta Post, 2020). This condition is the consequence of the beliefs of the young people that farmers are low-wage workers, which is suitable for those who have a poor background and limited educational background (SMERU Research Institute, 2016). The issue is limited to human resources and according to Indonesia Statistic Data, Indonesia's agricultural land has decreased from 7.75 million hectares to 7.46 million in just 6 years (The Jakarta Post, 2020).

Keywords: Agriculture, Agriculture Ecosystem, Digital Ecosystem
Reshaping Islamic Corporate Reports
Authors: Birton M. Nur A. , Sholihin Mahfud , Muttaqien Muhammad Faizal
Published: June 2022

Islamic Corporate Reports (ICRs) is an alternative synthesized Islamic accounting theory to explain and improve the ethical foundations and implications of Islamic financial reports guided by AAOIFI. This article aims to sharpen the ethical foundations of Baydoun & Willett's ICRs, particularly regarding the Islamic value-added reporting (VAR) as well as projecting its implications on the shape and substance of the report. Baydoun & Willett suggested the addition of current value to complement the historical value for the balance sheet and VAR as a substitute for the income statement. This study employs qualitative approach by examining three fiqh principles. The principle of al kharaj bi al dhaman (cost-reflected earning), maslaha (welfare) and nafaqa (expenditure) to build a new perspective on Baydoun & Willett's VAR. The examination of three fiqh principles on VAR can be understood in a broader perspective in a smooth and relatable way by the Muslim community because it has stronger roots in the legacy of Islamic scholars, especially in the financial sector.

Keywords: al kharaj bi al dhaman , Islamic corporate reports, maslaha, nafaqa, value-added reporting,
PENGENALAN JENIS CANDI BERDASARKAN BENTUK DAN MODELNYA MENGGUNAKAN MOTODE CONVOLUTIONAL NEURAL NETWORK (CNN) PADA YOLLO v3
Authors: Ahmad Baihaqi Kiki , Zonyfar Candra , Nugraha Bagja
Published: June 2022

Berkembangnya teknologi yang cepat dan merambah semua sendi kehidupan. Termasuk sistem cerdas yang digunakan pada segmen cagar budaya yang penting untuk diperkenalkan kepada generasi muda bahkan memperkenalkan kepada bangsa lain bahwa ada cagar budaya berupa situs candi yang memiliki beberapa jenis candi dalam 1 komplek situs percandian candi jiwa yang terletak di Kabupaten Karawang. Tentu dengan model dan ciri khas bangunan candi tersebut, perlu pembuktian algoritma Convolutional Neural Network (CNN) dapat diterapkan dalam pendeteksian jenis candi dimana candi memiliki cirinya sendiri. Ada sumber yang menjelaskan bahwa CNN ini merupakan algoritma terbaik dalam sistem deep learning. Proses penarikan kesimpulan dalam algoritma melewati tahap klasifikasi dan tahap pembelajaran menggunakan backpropagation, yaitu setiap neuron dipresentasikan dalam bentuk dua dimensi. Metode pengembangan sistem berdasarkan kecerdasan buatan ini akan belajar dari data yang diinputkan sehingga semakin banyak inputan yang diberikan maka semakin cerdas dalam menarik kesimpulan. Sehingga sistem ini nantinya menghilangkan tahap feature extraction yang dilakukan secara manual pada machine learning. Hasil dari penelitian ini memiliki akurasi lebih dari 70%, sehingga CNN yang ada pada YOLO v3 ini baik untuk mendeteksi bentuk candi.
Implementasi MAC Address Register Untuk Mengatasi Pengguna Anonim Dalam Jaringan
Authors: Pramudya Pahala Bima , D Djuniadi
Published: June 2022

Keamanan adalah faktor penting di era digital saat ini. Privasi data dan kelancaran beraktivitas merupakan hal yang sangat membutuhkan keamanan. Penerapan sistem keamanan dalam suatu jaringa merupakan fokus utama seorang developer jaringan dan administrator jaringan. Keamanan jaringan terdapat berbagai macam metode dengan fungsi yang berbeda-beda untuk mengatasi bermacam ancaman. Salah satu keamanan jaringan yang paling dasar adalah berupa hak akses. Penerapan MAC Adress Register sebagai keamanan dasar yang dapat mencegah Pengguna Anonim mengakses sistem jaringan. Langkah dasar yang digunakan berupa memanajemen akses untuk masuk ke dalam jaringan dengan identifikasi data user. MAC Address merupakan identitas device yang unik. Tujuan dari studi  ini untuk melakukan simulasi keamanan jaringan menggunakan Cisco Packet Tracer dengan metode MAC Address Register. Hasil yang didapatkan dari simulasi adalah sistem yang mampu mencegah Pengguna Anonim untuk mengakses jaringan, dan mengizinkan pengguna dengan MAC Address registered untuk mengakses jaringan.
Efektifitas Algoritma Data Mining dalam Menentukan Pendonor Darah Potensial
Authors: Yasin Aldi , Yuniarti Asry , Adi Nugroho Yohanes
Published: June 2022

Darah merupakan salah satu cairan fungsional yang memiliki banyak manfaat sehingga sangat dibutuhkan oleh tubuh manusia agar dapat bertahan hidup. Persediaan darah di suatu negara setiap tahunnya harus terpenuhi sesuai dengan ketentuan dari WHO. Namun kebutuhan darah di Indonesia hingga saat ini masih belum terpenuhi. Hal ini mengakibatkan banyak orang sulit untuk mendapatkan darah dan harus mencari calon pendonor darah. Penelitian ini memuat solusi untuk mendapatkan calon pendonor darah potensial dengan memanfaatkan kemajuan teknologi yaitu teknik data mining. Penelitian ini bertujuan untuk mencari keefektifan dari 2 algoritma klasifikasi data mining yang diimplementasikan ke dalam Bahasa Pemrograman Python dengan tools Jupyter Notebook dan software RapidMiner. Hasil penelitian menghasilkan bahwa algoritma KNN mempunyai accuracy 78,00% dengan menggunakan software RapidMiner, dan 68,66% dengan menggunakan tools Jupyter Notebook sedangkan algoritma Naive Bayes menghasilkan nilai accuracy 71,33%, dan 73,33%. Dilihat dari nilai Accuracy menunjukan bahwa algoritma KNN yang diimplementasikan menggunakan software RapidMiner memiliki nilai accuracy paling tinggi sehingga dalam penelitian ini algoritma KNN merupakan algoritma yang paling efektif dalam mencari calon pendonor darah
RESILIENSI PADA LANJUT USIA PEREMPUAN YANG DITINGGAL MATI PASANGAN HIDUPNYA DI DESA MARGOMULYO KECAMATAN GLENMORE BANYUWANGI
Authors: Solehati Nasihatus , Alwi Muhammad Muhib
Published: June 2022

Masa tua merupakan tahap terakhir dalam fase perkembangan manusia. Di fase ini manusia akan mengalami kemunduran dan perubahan dalam hidupnya, terutama ketika mereka kehilangan pasangan hidup. Kehilangan pasangan hidup membuat lanjut usia mengalami luka yang mendalam dan merasa terpukul atas kejadian yang dialaminya terutama lanjut usia perempuan. Lanjut usia akan mengalami perubahan peran tanpa dampingan pasangan hidupnya karena ia akan menjalani dan mencukupi kebutuhanya tanpa dampingan suami disisinya. Maka perlu adanya resiliensi untuk membangun kekuatan pada lanjut usia perempuan yang ditinggal mati pasangan hidupnya agar mampu bertahan dalam menghadapi permasalahan dalam hidup. Penelitian ini bertujuan untuk mengetahui gambaran resiliensi pada lanjut usia perempuan yang ditinggal mati pasangan hidupnya di Desa Margomulyo dan untuk mengetahui faktor pendukung dan menghambat proses resiliensi pada lanjut usia perempuan yang ditinggal mati pasangan hidupnya di Desa Margomulyo. Dalam penelitian ini menggunakan pendekatan kualitatif deskriptif dengan jenis penelitian studi kasus. Teknik pengumpulan data menggunakan observasi, wawancara dan dokumentasi. Analisis data menggunakan reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian menujukan kelima subjek memiliki daya reselien yang baik. Hal ini dapat dilihat dari kondisi lanjut usia yang mampu mengotrol emosi sedih, mampu mengendalikan keinginan dalam dirinya, semangat bekerja, berusaha ikhlas, mampu berfikir positif dan memiliki sikap peduli terhadap orang lain, mempunyai keyakinan bahwa dirinya mampu menyesaikan masalah, mampu meningkatkan aspek positif pada dirinya. Faktor yang mendukung resiliensi lanjut usia perempuan tersebut adalah faktor spiritual dan faktor sosial dan yang menghambat yaitu faktor sosial dan ekonomi.
PERAN ORANG TUA DALAM PENGGUNAAN METODE SELF BUILDING AT HOME ANAK TUNAGRAHITA PADA PEMBELAJARAN ADL (ACTIVITY DAILY LIVING)
Authors: Prastyo Eryo Kukuh , Islamudin Haryu
Published: June 2022

Penelitian ini bertujuan untuk mendeskripsikan dan menjelaskan peran orang tua dalam mendampingi belajar anak Tunagrahita dan untuk mendeskripsikan efektivitas metode Self-building At Home siswa SDLB YPAC Jember dalam pendampingan ADL (Activity Daily Living) juga untuk mengetahui kendala dan hambatan-hambatan apa saja yang dialami orang tua dalam mendampingi anak selama belajar dirumah. Fokus masalah yang diteliti skripsi ini adalah : 1) Bagaimana peran orang tua dalam pendampingan belajar anak Tunagrahita dengan metode Self building At Home siswa SDLB YPAC Jember?, 2) Bagaimana efektivitas metode Self-building At Home siswa SDLB YPAC Jember dalam pendampingan ADL (Activity Daily Living)? 3) Bagaimana kendala dan hambatan-hambatan yang dialami oleh orang tua dalam mendampingi belajar anak Tunagrahita dirumah? Penelitian ini menggunakan metode kualitatif dengan pendekatan deskriptif, menganalisis proses pelaksanaan metode Self-building At Home pada pembelajaran activity daily living siswa SDLB YPAC Jember. Adapun teknik pengumpulan data menggunakan wawancara semi terstruktur, Observasi partisipatif dan dokumentasi. Untuk analisis data menggunakan reduksi data, penyajian data dan verifikasi, sedangkan untuk keabsahan data menggunakan triangulasi sumber dan triangulasi teknik. Penelitian ini memperoleh kesimpulan 1) peran orang tua sangatlah penting bagi perkembangan belajar siswa dirumah selama pandemi. 2) pembelajaran activity daily living cukup efektif dilaksanakan dirumah siswa dengan model guru kunjung. Pembelajaran tersebut dilaksanakan satu minggu sebanyak 2–3 kali selama pandemi, tergantung dengan situasi dan kondisi siswa. 3) kendala yang dialami oleh orang tua saat mendampingi belajar anak Tunagrahita selama pandemi yaitu rasa bosan anak dalam belajar, dalam mengatasi kendala tersebut orang tua melakukan hal yang anak sukai terlebih dahulu sehingga anak bisa bersemangat kembali dalam belajarnya.
HUBUNGAN ANTARA REGULASI DIRI DAN RESILIENSI DALAM MENGERJAKAN SKRIPSI PADA MAHASISWA PROGRAM STUDI PENDIDIKAN AGAMA ISLAM DI INSTITUT AGAMA ISLAM IBRAHIMY BANYUWANGI
Authors: Fathoni Moh. Hadi , Alwi Muhib
Published: June 2022

Penelitian ini bertujuan untuk memahami tingkat regulasi diri mahasiswa, tingkat resiliensi mahasiswa dan untuk memahami hubungan antara regulasi diri dn resiliensi mahasiswa yang sedang mengerjakan skripsi di IAII Banyuwangi.

Fokus masalah pada skripsi ini adalah: 1) Bagaimana tingkat regulasi diri mahasiswa yang sedang mengerjakan skripsi di IAII Banyuwangi? 2) Bagaimana tingkat resiliensi mahasiswa yang sedang mengerjakan skripsi di IAII Banyuwangi? 3) Adakah hubungan antara regulasi diri dengan resiliensi terhadap mahasiswa yang sedang mengerjakan skripsi di IAII Banyuwangi

Tujuan dari skripsi ini adalah: 1) untuk memahami tingkat regulasi diri mahasiswa yng sedang mengerjakan skripsi di IAII Banyuwangi. 2) untuk memahami tingkat resiliensi mahasiswa yang sedang mengerjakan skripsi di IAII Banyuwangi. 3) Mengidentifikasikan hubungan regulasi diri dengan resiliensi terhadap mahasiswa yang sedang mengerjakan skripsi di IAII Banyuwangi.

Untuk mengidentifikasi permasalahan tersebut, Jenis penelitian yang digunakan dalam skripsi ini menggunakan metode penelitian kuantitatif, dengan jumlah populasi mahasiswa IAII Banyuwangi sebanyak 136 orang dan sampel yng digunakan sebanyak 25% yakni 36 orang. Data dalam penelitian ini diperoleh dengan menggunakan skala regulasi diri dan resiliensi.

Penelitian ini memperoleh kesimpulan. 1) Tingkat Regulasi Diri pada mahasiswa fakultas Tarbiyah IAI Ibrahimy genteng banyuwangi berada pada kategori kuat dengan persentase mencapai 91,7%. 2) Tingkat Resiliensi pada mahasiswa yang sedang mengerjakan skripsi pada mahasiswa fakultas Tarbiyah IAI Ibrahimy genteng banyuwangi berada pada kategori sangat lemah dengan persentase mencapai 74,6%. 3) Terdapat hubungan yang positif antara regulasi diri dengan resiliensi. Semakin tinggi regulasi diri yang dimiliki seorang mahasiswa maka semakin tinggi tingkat resiliensi, sebaliknya semakin rendah regulasi diri mahasiswa maka semakin rendah pula tingkat resiliensi.
POLA PEMBINAAN KEMANDIRIAN SEBAGAI UPAYA MENGURANGI STRES PADA WARGA BINAAN DI LAPAS KELAS IIA BANYUWANGI
Authors: Mardlatillah Sandi Diana , Makki M. Ali
Published: June 2022

Lingkungan lapas berbeda dengan lingkungan pada umumnya karena ruang gerak yang dibatasi dan aturan-aturan yang harus ditaati. Ruang gerak yang dibatasi tidak menutup kemungkinan bahwa warga binaan merasakan stres. Stres merupakan fenomena psikofisik yang manusiawi dimana hal itu sebagai respon (reaksi) fisik dan psikis yang menimbulkan perasaan tidak enak, tidak nyaman, atau mudah tertekan dengan tuntutan yang sedang di hadapi. Penelitian ini berfokus pada, 1) bagaimana pola pembinaan kemandirian pada warga binaan di lapas kelas IIA Banyuwangi? 2) bagaimana manfaat pembinaan kemandirian sebagai upaya mengurangi stres pada warga binaan di lapas kelas IIA Banyuwangi? Metode yang digunakan pada penelitian ini adalah pendekatan kualitatif dengan model penelitian deskriptif. Metode pengumpulan data menggunakan wawancara, dokumentasi, dan observasi. Hasil dari penelitian ini menunjukkan bahwa, penerapan pola pembinaan kemandirian oleh petugas yaitu dengan diadakan pelatihan, belajar dari teman dan petugas hanya sebagai pengawas saja atau fasilitator. Manfaat pembinaan kemandirian yaitu sebagai bekal untuk membuka usaha secara mandiri bagi warga binaan, menjadi wadah untuk mengasah kembali kemampuan selama menjalani masa tahanan, dan melalui kegiatan pembinaan kemandirian warga binaan mampu mengelola stres yang dirasakan dengan mengikuti program yang disediakan sesuai kemampuan masing-masing
MANAJEMEN KEPEMIMPINAN KEPALA SEKOLAH DALAM PERSPEKTIF PSIKOLOGI PENDIDIKAN
Authors: Ach. Faridul Ilmi Ach. Faridul Ilmi
Published: June 2022

Tujuan penelitian ini adalah untuk mendeskripsikan karakteristik kepemimpinan kepala sekolah, mendeskripsikan karakteristik psikologis kepemimpinan kepala sekolah, dan merancang model kepemimpinan kepala sekolah dalam perspektif psikologis. Penelitian ini dilakukan di SMA Negeri MAN 1 Jember. Metode penelitian yang digunakan adalah penelitian kualitatif dengan desain studi kasus. Teknik pengambilan data melalui wawancara, observasi, dan dokumentasi. Analisis data yang digunakan adalah analisis model interaktif. Hasil penelitian menunjukkan bahwa karakteristik kepemimpinan yang ditunjukkan oleh kepala sekolah adalah objektif, demokratis, ramah, humoris, jujur, disiplin, tegas, mampu mengendalikan emosi, menghargai, memotivasi, memiliki sikap kekeluargaan kepada seluruh anggota, adil, kuat dan religius. Berdasarkan karakteristik psikologis kepemimpinan kepala sekolah adalah pemimpin yang menunjukkan pribadi yang tenang, santai, sabar, teliti, tidak mudah terpengaruh, dan memiliki kesadaran diri yang tinggi. Model kepemimpinan kepala sekolah dalam perspektif psikologis mencerminkan atribut optimis dan apatis.
THE INFLUENCED FACTORS OF SPIRITUAL WELL-BEING: A SYSTEMATIC REVIEW
Authors: Rahmat Hayatul Khairul , Basri A. Said Hasan , Putra Rezki Masda , Mulkiyan M , Wahyuni Sri Wanda , Casmini C
Published: June 2022

Well-being in essence is not just material or physical prosperity, but how each individual gets the opportunity to develop his full potential, including spirituality. This study aims to explore the factors that influence spiritual well-being. The method used in this research is a systematic review. The findings of this study are factors that affect spiritual well-being including: mental health, spiritual coping, life satisfaction, hope, primary emotions, mindfulness, self-compassion, perceived social support, quality of life, adjustment to chronic diseases, psychological disorders, psychological well-being, and psychological resilience.
PERSPEKTIF BARU PENELITIAN KONSELING: METODE KUALITATIF DAN KUANTATIF SECARA ONLINE
Authors: Miharja Sugandi
Published: June 2022

This paper attempts to present the use of online media in counseling research. The online research method is a new trend, where researchers can collect data through the internet media. With that being said, there’s a question arises, “what is the best online media” so that research gets data that meets the validity standards in scientific research. The research was conducted at the Aleogama Porto Guidance Counseling community, which is located at the Aleogama.com website, in Bandung. They carry out counseling service activities using quantitative and qualitative data in an integrated manner. This research approach uses a qualitative study. The data were collected using observation, documentation and interviews. Observations are aimed at the online service process. Documentation in the form of applications and printed data. The interviews were aimed at the components of their human resources, including public relations, coordinators, hosts, testers and administrators. The results of data collection show that using both quantitative and qualitative approaches, the use of online media can provide time effectiveness, maximize human resources and reduce costs in conducting research. A more detailed explanation of the strengths, weaknesses and ways of obtaining data by the research subjects either through questionnaires, surveys or interviews, for counseling research is also described. Either with or without the regulations validated to minimize direct physical contact, online media has contributed effectively in developing the research and theory concerned.
Study of transient characteristics of BAW filters under high power levels
Authors: Fan Yang , Ge Wang
Published: June 2022

The improvement of power capacity would benefit greatly from the analysis of transient characteristics of bulk acoustic wave (BAW) devices. For this purpose, a measurement system was established, which could capture the temperatures and the insertion loss (IL) of the BAW devices simultaneously. Based on the obtained testing data of four different commercial BAW filters, we clarified the time dependence of device temperature and IL. The results showed that the BAW filters would exhibit higher power capacity with higher threshold frequency and a lower slope of the characteristic curves. This prompts us to propose an evaluation method for BAW filters under high power levels, which could improve the efficiency of device selection and performance prediction.
Impact of the European Union Regulations on Indonesian Oil Palm Smallholder Farmers
Authors: Hasan Mohamad Fadhil , Fadhil Ilma , Fahmid Mirah M. , Ahmad Tauhid
Published: June 2022

In 2020 Indonesian smallholder farmers produced around 35 % of the total palm oil production, the most traded vegetable oil. Smallholders play an essential role in developing country economies – most strikingly due to their success at reducing poverty and improving social benefits. The cultivation of palm oil has proven benefits for the smallholders themselves and the local community. However, oil palm smallholders are at risk of being cut out of global supply chains by European union (EU) regulations. The EU’s discrimination against palm oil smallholders is wide-ranging, including the EU Renewable Energy Directive II and the forthcoming Due Diligence Regulation imposing restrictions designed to undermine Indonesian palm oil in the global marketplace. This paper elaborates on how palm oil smallholders contribute to desirable economic and social goals and how the approach of the EU is deliberately undermining those goals.
Interpretasi Makna Wasathiyah Dalam Perspektif Al-Qur’an (Suatu Pendekatan Tematik)
Authors: Muir Syamsuddin , Syahril Syahril , Suhaimi Suhaimi
Published: June 2022

Kehadiran berbagai ragam fenomena dan dinamika Islam kekinian telah banyak menghabiskan analisa dari para pemerhati terutama kaum intelektual dalam menguak misteri tentang terorisme, fundamentalisme, dan radikalisme dalam Islam. Tujuan penelitian ini untuk melemahkan otoritas politik dengan jalan jihad. Artinya, gerakan-gerakan keagamaan radikal ini menjadikan jihad sebagai salah satu metode untuk mencapai cita-citanya, yakni tatanan sistem Islam (al-nizām al-Islāmi). Penelitian ini menggunakan metode penelitian library research dengan jenis penelitian studi teks kewahyuan. Hasil penelitian menunjukkan bahwa kata ummat diartikan sebagai para penganut atau pengikut suatu agama, apakah itu Islam atau selain Islam. Dan pengertian wasathiyah adalah jalan tengah atau moderat. Dengan demikian, ummat yang wasathiyah diartikan sebagai pengikut agama yang mengambil jalan tengah atau penganut prinsip-prinsip moderat dalam kehidupan sosial. Penelitian ini berkontribusi terhadap isu-isu kemasyarakatan berbasis agama dan upaya untuk menjaga nilai-nilai bangsa serta keutuhan bangsa serta menjadi sebuah kajian yang bisa mencerahkan bagi generasi milenial dalam memahami makna dari kata wasathiyah sehingga sejalan dengan keharmonisan tatananan masyarakat di Indonesia yang majemuk.