bluuebunny/crossref_metadata_2025 huggingface dataset:
On Translating and Drafting Sharia Legal Terms and Expressions in Saudi Contracts
Authors: Nawaf Jaber Alhomoud Ghassan
Published: December 2022

The difficulty in translating legal sharia expressions and terminologies used in contracts arises from semantic, syntactic, pragmatic, contextual, and cultural features of the Islamic sharia expressions. The present study aims to address the problems arising when translating these contracts from Arabic into English and vice versa. It also aims to reassess the translations of several international business contracts translated from Arabic into English and vice versa to verify whether the legal Islamic terms and expressions have been accurately rendered or not. The Saudi legal system is based completely on sharia law. The Saudi contracts abound with religious expressions and terms, which sometimes have no equivalence in the English language. There is a crystal-clear cultural–religious gap between Arabic and English. The language of contracts must be accurate, precise, meaningful, and comprehensible. Any slight difference in translating these contracts might result in the loss of individual rights, which affects the foreign investments and the social life of residents and citizens. The present study is a qualitative study that adopts a critical hermeneutic method to address the highly controversial issues relating to the translation of Islamic legal terms and expressions. The study has found that the Islamic legal terms and expressions are translatable providing that the translator could use a hermeneutical translational approach. The study is original in the sense that it deals with the problems of translating the religious expressions embedded and constituted in the Saudi contracts.
XIAP and PHB1 Regulate Anoikis through Competitive Binding to TRAF6
Authors: Yang Bo , Lou Chao , Chen Shengkai , Zhang Zhiyuan , Xu Qin
Published: December 2022

Anoikis resistance is a prerequisite for circulating tumor cells to survive. However, the mechanism underlying anoikis resistance is poorly understood. In the current study, the effect of TNF receptor–associated factor 6 (TRAF6)-induced NF-kB activation on anoikis susceptibility in tumor cells was evaluated. Differential TRAF6-binding proteins in anoikis-sensitive versus anoikis-resistant tumor cells were screened by LC/MS-MS analysis. The effects of TRAF6-binding proteins on the stability of TRAF6, the activation of NF-kB signaling and anoikis susceptibility in tumor cells were detected. We found that the loss of TRAF6 expression is an important molecular event linked to anoikis. X-linked inhibitor of apoptosis protein (XIAP), an E3 ligase, can bind, ubiquitinate, and degrade TRAF6 and may lead to inactivation of NF-κB signaling and anoikis sensitivity. High expression of prohibitin 1 (PHB1) competes with XIAP for binding to TRAF6 and confers anoikis resistance to tumor cells. PHB1 and TRAF6 knockdown eliminated tumor cells from the circulation in vivo. Significant correlations between elevated PHB1 and TRAF6 expression and distant metastasis were observed in patients with oral cancer. Collectively, we elucidated a novel mechanism governing anoikis. Our data also indicated that TRAF6 and PHB1 are potential therapeutic targets for tumor cells disseminating in the circulation.

Implications:

Our data implicate that PHB1 competes with XIAP for binding to TRAF6 and confers anoikis resistance to tumor cells.
Which Health-Related Quality of Life Items Most Affect Acne Patients?
Authors: Chernyshov Pavel V. , Sampogna Francesca , Zouboulis Christos C. , Boffa Michael J. , Marron Servando E. , Manolache Liana , Pustišek Nives , Bettoli Vincenzo , Koumaki Dimitra , Chubar Olha , Pochynok Tetiana V. , Mintoff Dillon , Bonitsis Nikolaos G. , Spillekom-van Koulil Saskia , Driessen Rieke J.B. , Chernyshov Andriy V. , Bewley Anthony Paul , Evers Andrea W.M. , Chernyshov Ivan P. , Tomas-Aragones Lucia
Published: December 2022

Background: Health-related quality of life (HRQoL) assessment in patients with acne is recommended by several national guidelines. There are several acne-specific HRQoL instruments. Objectives: Participants of the European Academy of Dermatology and Venereology (EADV) Task Forces (TFs) on QoL and Patient Oriented Outcomes (PO) and Acne, Rosacea, and Hidradenitis Suppurativa (ARHS) agreed to scrutinize aspects of existing acne-specific HRQoL instruments for their relevance in international study. Methods: Consensus agreement on items related to QoL was reached after an independent assessment by seven experts from the EADV TFs on QoL and PO, and a list of 97 items was prepared and proposed to a group of acne patients. In order to have data from patients to check if any important topics were overseen, another group of acne patients from participating countries was asked to list how acne influenced different aspects of their lives. Results: Based on results obtained from 601 acne patients from nine countries, most of the items and topics showed low relevance for acne patients especially during the previous month or shorter time periods. Based on percentage of relevance and factor analysis, short (6 items) and long (45 items) lists of the most relevant topics were formed. Conclusion: Most of the items and topics from the initial list showed low relevance for acne patients. None of the identified acne-specific HRQoL instruments contain all the items that were deemed most relevant to acne patients. For this reason, participating members of the EADV TFs on QoL and PO, and ARHs are in the process of developing a new acne-specific HRQoL instrument.
Irrigation Solutions Negatively Affect the Viability and Function of Human Fibroblasts: An in vitro Study
Authors: Sosnoski David , Dietz Paula , Bou-akl Therese , Ren Wei-Ping , Markel David
Published: December 2022

Introduction: Multiple irrigation solutions are used in orthopedic surgeries although there are limited studies on their lasting effects on human tissues. The purpose of this work was to investigate the cytotoxic effects of the irrigation solutions Bacitracin, Clorpactin (sodium oxychlorosene), Irrisept (0.05% chlorhexidine gluconate), and Bactisure (ethanol 1%, acetic acid 0.6%, sodium acetate 0.2%, benzalkonium chloride 0.013%, and water) on 3D cultures of human fibroblasts. Methods: Two independent experiments with 6 replicates were performed for the following conditions: Control (saline), bacitracin, Clorpactin, Irrisept, and Bactisure. Human fibroblast cell sheets were exposed to these solutions (1 or 2 min), followed by three washes with warm saline. Cell sheets were then cultured for additional 5- and 7-day posttreatment. Cell viability was measured using the alamarBlue (AB) assay. The more cytotoxic the irrigant, the lower the AB reduction. Results: For 1-min exposure time, significant differences in AB reduction were noted in Clorpactin, Irrisept, and Bactisure groups compared to control at both 5 days (Clorpactin p = 0.0003, Irrisept p = 7.31 × 10−15, Bactisure p = 6.86 × 10−14) and 7 days posttreatment (all groups p < 0.0001). The results were similar in the 2-min exposure groups. Bacitracin-treated fibroblasts displayed no significant difference at all measurement times compared to control. Discussion: Impacts of irrigation solution exposure on cell viability were varied. Irrisept and Bactisure showed the highest cell toxicity even after a brief exposure (1 min), while bacitracin and Clor­pactin exposure showed smaller impacts on cell viability as compared to saline controls. This in vitro study provided insight into the effects of the irrigants on human cells and provides the groundwork essential to move to in vivo studies. Our findings raised the concern that some irrigation solutions may have negative impacts on wound healing and healthy cellular response.
Considerations for Choice of Cranioplasty Material for Pediatric Patients
Authors: Still Megan E.H. , Samant Sonja , Alvarado Abraham , Neal Dan , Governale Lance S. , Ching Jessica A.
Published: December 2022

Introduction: Optimal material and timing of cranioplasty in the pediatric population continue to be debated. Autologous and alloplastic materials have various indications for use and risk factors for complications. Methods: A single-center retrospective cohort study was undertaken of all pediatric patients who underwent cranioplasty with any material from 1991–2021. Results: 149 cranioplasty implants were included. Younger age (6 years old or under), a diagnosis of craniosynostosis as reason for implant, use of autologous bone, and shorter times to cranioplasty were predictive of need for revision surgery. No factors studied had a statistically significant impact on rate of removal of implant at time of revision surgery. Conclusion: Autologous and alloplastic cranioplasty materials both have good outcomes with low rates of revision surgery in the pediatric population. Alloplastic implants may be considered in the setting of infection as reason for craniectomy given the lower rate of revision surgery and need for removal. Patients with craniosynostosis as reason for cranioplasty have a higher risk of requiring revision or additional surgeries, regardless of implant used.
Prognostic Value of Left Ventricular Global Longitudinal Strain in Patients With Congenital Heart Disease
Authors: Egbe Alexander C. , Miranda William R. , Anderson Jason H. , Pellikka Patricia A. , Connolly Heidi M.
Published: December 2022

Background:

Left ventricular global longitudinal strain (LVGLS) has been shown to improve risk stratification in patients with LV systolic dysfunction and subsequent recovery of LV ejection fraction (LVEF) in the acquired heart disease population. The purpose of this study was to assess the relationship between LVGLS and cardiovascular events (heart failure hospitalization, sustained ventricular tachycardia/appropriate shock, heart transplant, or cardiovascular death) and deterioration in LVEF (absolute decrease in LVEF ≥10% to LVEF <50%) in adults with congenital heart disease.

Methods:

Retrospective cohort study of congenital heart disease patients with previous diagnosis of LV systolic dysfunction (LVEF <50%) and subsequent recovery of LVEF (absolute increase in LVEF of ≥10% to LVEF ≥50%) on subsequent echocardiogram (index echocardiogram). Based on the index echocardiogram, patients were divided into normal LVGLS (absolute LVGLS >18%) versus abnormal LVGLS (absolute LVGLS ≤18%) groups.

Results:

Of 193 patients with recovered LVEF, 86 (45%) had normalization of LVGLS at index echocardiogram. A higher absolute LVGLS and use of renin angiotensin aldosterone system antagonist was associated with a lower risk of cardiovascular events and subsequent deterioration in LVEF, while hypertension was associated with higher risk of cardiovascular events and deterioration in LVEF.

Conclusions:

These results suggest that patients with congenital heart disease with recovered LVEF remained at risk for adverse outcomes, and LVGLS can be used to identify patients at risk for adverse outcomes. Medical therapy for heart failure and treatment of hypertension may reduce the risk of adverse outcome, but these findings require empirical validation, hence the need for a clinical trial.
Charles Lang Freer’s Japanese Ceramics
Authors: Coman Sonia
Published: December 2022

At the turn of the twentieth century through its first decades, in the context of an increasingly international and interconnected Japonisme, the collecting activity of Detroit-based industrialist Charles Lang Freer (1854–1919) in the area of Japanese ceramics epitomized a key transition from a collector’s individual taste to the collection’s role in the public discourse on Asian art. This essay traces this evolution by exploring Freer’s collecting patterns, the influence of his network of dealers and advisors, and his relationship with the art market. At the intersection of personal choice and public prominence, Freer’s Japanese ceramics became an instrument of legitimization for emerging canons of Japanese art.
Le Divan Japonais: Japanomania by Design
Authors: Weisberg Gabriel P.
Published: December 2022

As one of the primary performance spaces in Paris during the 1890s, the Divan Japonais had several owners who featured the spot in posters advertising what was happening there. The most famous of these was one by Toulouse-Lautrec that has become a recognizable image for the entire locale. Examining the posters that advertised the location from the early 1890s allows us to grasp the changing character of both performances and locale.
10. How Conservation Practice Can Generate Evidence
Authors: Ockendon Nancy , Cadotte Marc W. , Eklund Johanna , Ferraro Paul J. , Fisher Martin , Hancock Mark , Worthington Thomas A.
Published: December 2022

Conservation practice provides a considerable opportunity to generate new evidence to inform future decision-making. Substantial resources are currently invested in data collection and monitoring, yet too often these are ineffectively designed, meaning the data gathered contributes little to building an evidence base. However, thinking in advance about how actions are implemented, data are collected, and results are shared can greatly increase the usefulness of the results. Controls, comparisons, replication, randomisation, and preregistration can all improve the value of the data collected.
12. Transforming Practice
Authors: Amano Tatsuya , Bako Longji , Best Marina , Boenisch Nicolas , Boersch-Supan Philipp , Browne Des , Buckley Yvonne , Burgman Mark , Cadotte Marc W. , Canessa Stefano , Cheng Samantha H. , Christie Alec P. , Citegetse Geoffroy , Cook Carly N. , Cooke Steven J. , Cranston Gemma , Dicks Lynn V. , De la Luz Angelita , Dickson Iain , Downey Harriet , Eklund Johanna , Esmail Nafeesa , Ferraro Paul J. , Field Alison , Fisher Martin , Freckleton Robert , Winifred F. Frick Winifred F. Frick , Godfray Hugh Charles Jonathan , Grainger Matthew J. , Green Rhys , Hancock Mark , Hemming Victoria , Hughes Jonathan , Irvine Robyn , Jackson Hazel A. , Keller Kaylene E. , Koricheva Julia , Latrémouille Charles , McBride Marissa , McLean Angela R. , McPherson Tom , Morgan William H. , Muir Matthew , Mukherjee Nibedita , O’Brien David , Ockendon Nancy , Parks Danni , Petrovan Silviu O. , C. Quinzin Maud C. , Randall Nicola , Rezaie Ali Mohammad , Roe Dilys , Rose David Rose , Rumpff Libby , Sahlin Ullrika , Salafsky Nick , Schindler Stefan , Sheldon Tom , Simkins Ashley T. , Smith Rebecca K. , Spencer Jonathan , Sutherland William J. , Tanshi Iroro , Taylor Nigel G. , Tew Eleanor R. , Thompson Des B.A. , Thornton Ann , Tinsley-Marshall Paul , White Thomas B. , Willott Kate , Wilson Jeremy D. , Wintle Bonnie C. , Worthington Thomas A. , Yamashita Hiromi , Young Lindsay C.
Published: December 2022

Delivering a revolution in evidence use requires a cultural change across society. For a wide range of groups (practitioners, knowledge brokers, organisations, organisational leaders, policy makers, funders, researchers, journal publishers, the wider conservation community, educators, writers, and journalists), options are described to facilitate a change in practice, and a series of downloadable checklists are provided.
1. Challenges for Public Investment in the EU
Authors: Brasili Andrea , Kolev Atanas , Revoltella Debora , Schanz Jochen
Published: December 2022

Chapter 1 by K. Atanas, D. Revoltella, A. Brasili, and J. Schanz describes how the war in Ukraine poses new challenges for public investment in the EU. It has worsened the macroeconomic environment by increasing uncertainty and raising energy and other input costs. Concerns over public debt and increases in current expenditure, to contain the impact of higher energy costs, might decrease government spending on investment. That said, large EU-wide programmes will be supporting governments’ investments over the coming years, in particular through the Recovery and Resilience Fund and RePowerEU. RePowerEU is designed to rapidly reduce dependence on Russian fossil fuels—a challenge that can be addressed only with coordinated policies and efforts both at the national and EU levels. While the cost may not be overwhelming, it comes on top of the large investment needs related to transitioning to a net-zero carbon economy. The solidarity within the European Union will need to be a key ingredient for successfully overcoming these challenges.
6. How Big Are Green Spending Multipliers?
Authors: Batini Nicoletta , Di Serio Mario , Fragetta Matteo , Melina Giovanni , Waldron Anthony
Published: December 2022

In Chapter 6, N. Batini, M. Di Serio, M. Fragetta, G. Melina, and A. Waldron argue that fixing the twin climate and biodiversity crises is still possible, but it requires stewarding the global economy within limits set by nature. The chapter addresses the question of whether there is “a trade-off between spending on the green economy and an economy’s strength,” and two key results are discussed. First, every dollar spent on green activities can generate more than a dollar’s worth of economic activity, whereas non-green spending returns less than a dollar. Second, for spending categories that are comparable, like renewable versus fossil fuel energy, multipliers on green spending are about double their non-green counterparts. The findings suggest that investments in energy and land/sea use transitions may be economically superior to those offered by supporting economic activities that involve unsustainable ways of producing energy and food.
13. Towards a Socially Just Green Transition
Authors: Alcidi Cinzia , Corti Francesco , Gros Daniel , Liscai Alessandro
Published: December 2022

Chapter 13 by C. Alcidi, F. Corti, D. Gros, and A. Liscai builds on the issue that finding a balance between the objectives of economic growth, environmental sustainability and social fairness has been one of the key priorities of the EU agenda in the last years. While the link between economic growth and social and ecological objectives has historically received much attention, the socio-environmental nexus has received much less. Some scholars recently attempted to identify the possible functions that the welfare state could perform to accompany the green transition. Based on this recent literature, the authors identify two main functions (activating and buffering) that are not mutually exclusive. An important distinction is made in the logic under which the welfare intervention is carried out. Two different types of logic can underpin eco-social policies: compensatory or integrated. They show that an integrated approach to social and environmental policies seems to be the most suitable solution to achieve green and positive social outcomes.
Combined and Single Doxorubicin/Naproxen Drug Loading and Dual-Responsive pH/Ultrasound Release from Flexible Metal-Organic Framework Nanocarriers
Authors: Karami Abdollah , Ahmed Ahmed , Sabouni Rana , Husseini Ghaleb A. , Paul Vinod
Published: December 2022

In this study, the flexible aluminum-based MIL-53(Al) metal-organic framework was loaded with doxorubicin (DOX) and naproxen (NAP) and was examined as a promising pH/ultrasound dual-responsive drug delivery system. The two drugs were encapsulated in MIL-53(Al) individually to produce
the DOX@MIL-53(Al) and NAP@MIL-53(Al) nanocarriers. They were also encapsulated as a dual-drug formulation to produce the DOX* + NAP*@MIL-53(Al) nanocarrier. The MOF nanoparticles were characterized using the Scanning Electron Microscopy (SEM), X-ray diffraction (XRD), Fourier Transform Infrared
spectroscopy (FTIR), and Dynamic Light Scattering (DLS) techniques. In the case of the DOX@MIL, the nanocarriers’ drug Encapsulation Efficiency (EE) and Encapsulation Capacity (EC) were 92% and 16 wt.%, respectively, whereas, in the case of NAP@MIL-53(Al), the average NAP EE and EC were
around 97.7% and 8.5 wt.%, respectively. On the other hand, in the DOX* + NAP*@MIL-53(Al) nanoparticles, the average DOX* EE and EC were 38.9% and 6.22 wt.%, respectively, while for NAP*, the average EE and EC were 70.2% and 4.49 wt.%, respectively. In vitro release experiments demonstrated
the good pH and Ultrasound (US) dual-responsiveness of these nanocarriers, with a maximum US-triggered DOX and NAP release, at a pH level of 7.4, of approximately 53% and 95%, respectively. In comparison, the measured release was around 90% and 36% at pH 5.3 for DOX and NAP, respectively.
In the case of the dualdrug formulation, the nanocarrier displayed similar pH/US dual-responsive behavior. Finally, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) results confirmed the biocompatibility and low cytotoxicity of MIL-53(Al) at concentrations up to 1000
μg/ml.
Lawsonia inermis Extract-Loaded Cellulose Acetate Nanofibrous Wound Dressings Alleviate Wound Inflammation Through PI3K/AKT/NFκB Signaling Pathway: A Preclinical Investigation
Authors: Zhang Aihui , Yang Ye , Zhang Qiang , Chen Xiaofeng , Jalili Saman
Published: December 2022

In this research, we aimed to combine the principles of herbal medicine and tissue engineering to develop a bioactive wound dressing. The nanofibrous scaffolds were produced via electrospinning of cellulose acetate/Lawsonia inermis extract (LIE) solution. The developed constructs
were studied regarding their interaction with fibroblast cells and their various physicochemical and biological properties. The wound healing potential of the prepared dressings was studied on a rat model skin wound. In vitro studies showed that cellulose acetate scaffolds loaded with
3% LIE had the highest cell protection capacity under oxidative stress and promoted the fibroblast cells proliferation. Therefore, this group was used for wound healing assay. In vivo study showed that LIE-loaded wound dressings had the highest epithelial thickness, collagen deposition,
and angiogenesis scores. Gene expression analysis showed that wounds treated with cellulose acetate/LIE wound dressings upregulated VEGF, b-FGF, and collagen type 2 genes. While, NFK-β and TNF-a genes expressions were significantly reduced by these dressings. This study implies
that local delivery of LIE via cellulose acetate scaffolds can alleviate inflammation and increase the expression of pro-healing genes.
In Vitro Evaluation of Ultrasound Effectiveness in Controlling Doxorubicin Release from Albumin-Conjugated Liposomes
Authors: Abuwatfa Waad H. , Paul Vinod , AlSawaftah Nour M. , Farooq Afifa , Awad Nahid S. , Husseini Ghaleb A.
Published: December 2022

Functionalized liposomes are among the most promising antineoplastic agents delivery vehicles. Contemporaneous to their accretion at the tumor site, they need to be potentiated to release their cargo using a suitable triggering modality. In this work, targeted Doxorubicin (DOX)-loaded
stealth liposomes were synthesized and functionalized with Human Serum Albumin (HSA) to target the overexpressed HSA receptors (HSA-Rs). The effects of low-frequency ultrasound (LFUS) in inducing DOX release from the synthesized liposomes were investigated In Vitro. DOX release increased
with the increasing power density of ultrasound. HSA conjugation to the liposomes increased their sensitivity to LFUS. Furthermore, HSA conjugation also enhanced the liposome’s cytotoxic activity and uptake by the cancer cells overexpressing HSA-Rs. This cytotoxic activity and cellular
uptake were further enhanced by triggering drug release from those targeted liposomes using LFUS. Combining HSA-targeted liposomes with LFUS is a promising approach in drug delivery.
Three Dimensional Modelling of Magnetohydrodynamic Bio-Convective Casson Nanofluid Flow with Buoyancy Effects Over Exponential Stretching Sheet Along with Heat Source & Gyrotactic Micro-Organisms
Authors: Makkar Vinita , Poply Vikas , Sharma Naresh
Published: December 2022

In current analysis, influence of buoyancy forces in MHD bioconvective non-Newtonian nanofluids over three dimensional exponential sheet has been studied numerically. Additionally, impact of heat source parameter along with convective conditions has been incorporated. Moreover, nanofluid
flow with gyrotactic microorganisms has been analyzed in presence of chemical reaction. Initially similarity variables are used for the conversion of partial differential equations into highly non-linear differential equations. Thusly, non-linear behavior of equations makes typical solutions
which are not solved analytically. So, computational MATLAB software is used to calculate results and graphs by following shooting algorithm with Runge Kutta Fehlberg technique using ODE45 solver. Present modeling investigates the influence of crucial fluid parameters especially; magnetic
M (0.1 ≤ M ≤ 0.9), Casson parameter β (0.09 ≤ β ≤ 0.13), permeability parameter Bθ, Brownian motion Nb (0.5 ≤ Nb ≤ 5.0), thermophoresis Nt (0.2 ≤ Nt ≤ 2.0), thermal Biot number
Bt (0.3 ≤ Bt ≤ 0.7), heat generation parameter Q (0.1 ≤ Q ≤ 0.5), Prandtl number Pr (0.1 ≤ Pr ≤ 0.9), concentration Biot number Bc (0.1 ≤ Bc ≤ 0.9), Lewis number Le
(1 ≤ Le ≤ 5), chemical reaction parameter Ch (0.1 ≤ Ch ≤ 0.9), bioconvective Lewis number Lb (0.1 ≤ Lb ≤ 2), Peclet number Pe (0.1 ≤ Pe ≤ 5), gyrotactic Biot number Bn (0.1 ≤
Bn ≤ 0.5), stretching ratio parameter c (0.1 ≤ c ≤ 0.3) and microorganism concentration difference parameter Ω (0.1 ≤ Ω ≤ 5.0). Final results are compared for Prandtl number and stretching ratio parameter along with residual errors.
It is inferred that motile concentration declines for larger bioconvective Lewis number whereas rises for motile gyrotactic microorganism Biot number.
Inclined Magnetized Flow of Radioactive Nanoparticles with Exponential Heat Source and Slip Effects: Keller Box Simulations
Authors: Abbas Tasawar , Al-Khaled Kamel , Raza Ahmed Haseeb , Ayadi Mohamed , Chammam Wathek , Khan Sami Ullah
Published: December 2022

Owing to the impressive thermal characterizations and uniform stability, the nanofluids reports novel significances in the thermal sciences, cooling phenomenon, controlling the heat transfer rate, solar systems, energy storage and many bio-medical applications. This thermal investigation
incorporates the numerical investigation of two-dimensional unsteady nanofluid flow over nonlinear stretched configuration with exploration of heat source/sink case with non-uniform relations. Also consider hydromagnetic flow with parameters of chemical radiation and slip effects. The following
of suitable variables, we convert the governing partial differential equation into ordinary differential equation. To solve these similarity equations using the numerical technique known as Keller box technique. Study reveals that the radiation parameter, velocity slip and chemical reaction
have major effects on the temperature, velocity, concentration, mass transfer, transfer of heat and Skin friction coefficient. The influence for parameters associated to the velocity change and heat transfer determination is observed graphically.
Nanofluid Based Pipe Flow Analysis in Absorber Pipe of Flat Plate Solar Collector: Effects of Inclination and Porosity
Authors: Panda R. C. , Panigrahi L. , Nayak M. K. , Chamkha A. J. , Sahoo S. S. , Barik A. K.
Published: December 2022

Nanofluid applications in solar collectors are an emerging area for enhanced heat transfer resulting in heat gain for domestic and industrial use. In the present work, the performance of a Flat Plate Solar Collector (FPSC) having water-CuO-based nanofluid has been studied. The effect
of the tilting angle of cylindrical pipe and porosity of porous material is investigated for this nanofluid-based FPSC. A numerical approach has been adopted to stimulate the governing equations in the tube. The similarity transformation simplifies the model (PDEs) into ordinary differential
equations (ODEs). The governing non-dimensional PDEs along with their appropriate boundary conditions are solved numerically using the 4th order Runge-Kutta method cum shooting technique. The impacts of significant and relevant physical parameters and physical quantities of interest are analyzed.
From the present study, it is observed that amplification of tilting angle and curvature parameter ameliorates the heat transfer rate while that of porosity parameter controls it effectively. A similar approach can be employed for other solar collectors to assess the heat transfer augmentation
by using nanofluids instead of existing fluids.
Numerical investigation on forced convection enhancement within an oil cooler through the simultaneous use of porous media and nanofluid
Authors: Sedighi Mohamad , Ayoobi Ahmadreza , Aminian Ehsan
Published: December 2022

Traditional strategies for improving heat transmission in industrial systems include nanofluids and porous inserts. In these kinds of systems, increasing the rate of thermal transmission can also be accomplished by utilizing porous materials that have a higher thermal conductance. Al2O3, CuO, and ZnO in engine oil (20w50) nanofluid are studied numerically in three dimensions to see how they affect forced convection in a porous media oil cooler. Within the oil cooler, the porous medium was placed. A two-phase mixture model was used in conjunction with the Darcy–Brinkman–Forchheimer equation indicating the drag forces to simulate nanofluid flow in porous media. In addition, utilizing temperature laboratory data, a more specific thermophysical feature of the fluid was identified and characterized. ANSYS-FLUENT, a commercial computational fluid dynamics (CFD) software, is used to partition the governing equations using the finite volume method. In addition, the thermal boundary parameters of the oil cooler walls were made to be temporally constant and spatially uniform. The effects of varying volume fractions (ranging from 0% to 5%), Darcy number (ranging from 10−2 to 102), overall Nusselt number, pressure reduction, and the performance evaluation criteria (PEC) were analyzed and compared for a variety of distinct nanoparticles. The increased Darcy number (10−2 to 102) had a significant effect on the enhanced heat transfer coefficient, according to the data. In light of the findings, it can be deduced that the high-volume percentage of the nanoparticles will improve thermal transmission and, more significantly, the PEC factor. Furthermore, the given variables were compared, leading to the creation of diagrams for different variables.
Hsa_circ_0019054 up-regulates HIF1A through sequestering miR-340–5p to promote the tumorigenesis of intrahepatic cholangiocarcinoma
Authors: Tang Jintian , Tang Runjuan , Gu Peng , Han Jing , Huang Wukui , Xue Feng
Published: December 2022

Background

Circular RNAs (circRNAs) have been uncovered to play an important regulatory function in the tumorigenesis of intrahepatic cholangiocarcinoma (ICC). Hsa_circ_0,019,054 was found to be increased in ICC. Here, we aimed to explore the action and mechanism of hsa_circ_0,019,054 in ICC carcinogenesis.

Methods

Quantitative real-time PCR (qRT-PCR) and western blotting were used to detect the levels of genes and proteins. The functional experiments were performed using in vitro 5-ethynyl-2’-deoxyuridine (EdU) assay, cell counting Kit-8 (CCK-8) assay, flow cytometry, and in vivo murine xenograft model. The glycolysis was analyzed by detecting glucose uptake and lactate level. The binding between miR-340–5 p and hsa_circ_0,019,054 or HIF1A (Hypoxia-inducible factor 1-alpha) was validated using pull-down, dual-luciferase reporter and RNA immunoprecipitation assays.

Results

Hsa_circ_0,019,054 expression was higher in ICC tissues and cells. Functionally, hsa_circ_0,019,054 silencing could suppress ICC cell proliferation and glycolysis active, as well as induce apoptosis. Mechanistically, hsa_circ_0,019,054 was demonstrated to act as a sponge for miR-340–5 p, which directly targeted HIF1A. Hsa_circ_0,019,054/miR-340–5 p/HIF1A formed a feedback loop. HIF1A was up-regulated, while miR-340–5 p was decreased in ICC tissues and cells. MiR-340–5 p re-expression attenuated ICC cell growth. Besides that, rescue experiments suggested that HIF1A overexpression or miR-340–5 p knockdown reversed the anti-proliferation and glycolysis arrest effects mediated by hsa_circ_0,019,054 silencing. Importantly, hsa_circ_0,019,054 silencing also impeded the growth of ICC in nude mice.

Conclusion

Hsa_circ_0,019,054 deficiency could attenuate the proliferation and glycolysis of ICC cells via miR-340–5 p/HIF1A axis.
A screw dislocation in a three-phase composite composed of an anisotropic elastic half-plane bonded to an isotropic elastic half-plane reinforced by a circular inhomogeneity
Authors: Wang Xu , Schiavone Peter
Published: December 2022

Using complex variable techniques, we solve the problem in anti-plane elasticity associated with a screw dislocation in a three-phase composite which is composed of an anisotropic elastic half-plane perfectly bonded to an isotropic elastic half-plane containing a circular elastic inhomogeneity. Analytical solutions are obtained for three typical cases: a screw dislocation in the isotropic half-plane in the exterior of the circular inhomogeneity, a screw dislocation inside the circular elastic inhomogeneity, a screw dislocation within the anisotropic half-plane. Explicit expressions of the image force acting on the screw dislocation are derived for each of the three cases. The numerical results indicate that at least one equilibrium position for the screw dislocation co-exists in each phase under certain conditions on the elastic constants.
Novel classification of proximal forearm perforator vein in the planning and creation of percutaneous and surgical Gracz-type arteriovenous fistulae
Authors: Shahverdyan Robert , Konner Klaus , Segerer Stephan , Wasse Haimanot
Published: December 2022

Background:

The perforator vein determines whether it is feasible to create a percutaneous (pAVF) or surgical “Gracz-type” arteriovenous fistula (sAVF). Creating a standard anatomic classification of the antecubital region is beneficial to both the selection of the appropriate device and/or procedure and technical outcomes. Accordingly, an analysis of a large cohort of patients undergoing pAVF/sAVF was performed, focusing on perforator vein anatomical suitability, and a novel anatomical classification of the antecubital region was developed and proposed.

Methods:

Between August 2018 and July 2022, chronic or end-stage kidney disease patients as well as patients anticipated an initiation of apheresis, who were referred for vascular access planning, underwent a standardized evaluation of upper extremities. A vessel mapping summary detailing the vasculature and the access creation plan was completed, indicating the anatomical suitability for sAVF and pAVF (Ellipsys and WavelinQ) techniques.

Results:

Of 524 patients, 36.5% were female (average age 65 years). 53.2% were on dialysis, 41.6% had diabetes, and 13.2% had a previously failed permanent dialysis access. The anatomy for successful pAVF creation was judged to be suitable in 54% of patients for an Ellipsys-pAVF, and 29.8% for WavelinQ-pAVF. Of the WavelinQ group, 54.4% had suitable anatomy for ulnar, 26.9% for radial, and 18.6% for both ulnar/radial anastomoses. Additionally, 60.7% had suitable anatomy for pAVF creation with at least one of the systems, while 22.5% were suited for both types of pAVF-systems. 80.3% were candidates for creation of a Gracz-AVF.

Conclusion:

Overall, we found that about 60% of patients are likely candidates for a pAVF, with 80% being candidates for creation of a Gracz-AVF. Male patients have significantly higher suitability for most types of AVF creation, and younger patients are more suitable for Ellipsys-pAVF and RCAVFs. Most importantly, a universal classification of perforator vein was developed, which is indispensable in modern vascular access planning.
Just a “Mouthpiece of Biased Elites?” Populist Party Sympathizers and Trust in Czech Public Service Media
Authors: Smejkal Klára , Macek Jakub , Slavík Lukáš , Šerek Jan
Published: December 2022

Existing research indicates that people with populist attitudes express lower trust in media, especially in Public Service Media. It is assumed that these people are alienated because of their values: populist ideology stems from anti-pluralism whereas Public Service Media promotes pluralism. This study tests this assumption by comparing the predictors of trust in Public Service Media between the populist party sympathizers and the sympathizers of other political parties in the Czech Republic. Two main expectations were included as predictors for trust in Public Service Media, specifically that media should conform to one's worldview (i.e., the cohesive dimension of trust in media) and that media should adhere to the normative standards of journalism (i.e., the normative dimension of trust in media). Using multigroup structural equation modeling, the study analyzes data from a 2019–2020 representative survey of the adult Czech population ( N  =  3,251). The results suggest that, for the populist party sympathizers, trust in Public Service Media links only to their expectation that media should conform to their worldview, while the sympathizers of other political parties expect normative standards to be maintained. This is interpreted and discussed as support for the assumption that this value-based mismatch links to the populist audience members' lower trust in Public Service Media.
Does group physiotherapy improve pain scores and reduce the impact of pelvic pain for women referred with persistent pelvic pain? A clinical trial
Authors: Beaumont Tara , Phillips Kate , Hull M Louise , Green Rose
Published: December 2022

Introduction:

This study aimed to test group Physiotherapy sessions – pain education and supervised exercise − in addition to individual consultations, for women referred with persistent pelvic pain (with/without endometriosis), with the primary outcomes being pain scores and pain impact.

Methods:

Parallel study design with three treatment arms: (1) usual care: a suite of individual Physiotherapy consultations; (2) introductory group pain education session followed by usual care and (3) introductory group pain education session followed by usual care and an 8-week supervised group exercise programme.

Results:

Ninety women were recruited (30/treatment arm), with 66 women (73%) completing their allocated treatment. Participants were aged between 16 and 51 years; endometriosis was confirmed in 41% ( n = 27/66) of the study population. Data was analysed using descriptive and inferential statistics. Statistically significant gains ( p < 0.05) in pain scores and pelvic pain impact scores were observed in all arms. Between groups, there was statistically significant improvement ( p < 0.05) in pelvic pain impact score for those who attended the group pain education session followed by usual care (arm 2), compared to usual care (arm 1) alone. There was no significant added improvement with the weekly supervised group exercise programme (arm 3), when compared to those who received the group pain education programme and usual care (arm 2).

Conclusion:

This study has demonstrated positive benefits of a group pain education session on pain scores and pelvic pain impact for women referred with persistent pelvic pain, when added as a precursor to individual Physiotherapy consultations.
The Outcomes of Transition from Pediatrics to Adult Care among Adolescents and Young Adults with HIV at a Tertiary Care Center in Bangkok
Authors: Rungmaitree Supattra , Thamniamdee Nuchanat , Sachdev Saranya , Phongsamart Wanatpreeya , Lapphra Keswadee , Wittawatmongkol Orasri , Maleesatharn Alan , Khumcha Benjawan , Hoffman Risa M. , Chokephaibulkit Kulkanya
Published: December 2022

Background: Adolescents and young adults with HIV (AYHIV) are at high-risk of loss to follow up and virologic failure, particularly during transition from pediatric to adult clinics. Methods: We reviewed the medical records of AYHIV to characterize retention and virologic suppression following their transition. Results: 101 AYHIV, 97% perinatally infected, were transferred at the median age of 20 (IQR: 19-21) years. At 1-year post-transition, 92.1% were retained in care and 73.3% had viral suppression and at 2-years the retention and viral suppression were 87.1% and 76.7%, respectively. Factors associated with viral suppression were transition at ≥ 20 years of age (aOR 4.38, 95% CI 1.41-13.65) and receiving first-line ART regimen, compared to second- or third-line regimens, at transition (aOR 6.05, 95% CI 1.55-23.58). Conclusion: Transition outcomes of AYHIV in our setting were suboptimal. There is a need for interventions to support AYHIV transition during this vulnerable period.
Establishment and validation of a predictive model of preeclampsia based on transcriptional signatures of 43 genes in decidua basalis and peripheral blood
Authors: Zhang Hongya , Li Xuexiang , Zhang Tianying , Zhou Qianhui , Zhang Cong
Published: December 2022

Preeclampsia (PE) has an increasing incidence worldwide, and there is no gold standard for prediction. Recent progress has shown that abnormal decidualization and impaired vascular remodeling are essential to PE pathogenesis. Therefore, it is of great significance to analyze the decidua basalis and blood changes of PE to explore new methods. Here, we performed weighted gene co-expression network analysis based on 9553 differentially expressed genes of decidua basalis data (GSE60438 includes 25 cases of PE and 23 non-cases) from Gene Expression Omnibus to screen relevant module-eigengenes (MEs). Among them, MEblue and MEgrey are the most correlated with PE, which contains 371 core genes. Subsequently, we applied the logistic least absolute shrinkage and selection operator regression, screened 43 genes most relevant to prediction from the intersections of the 371 genes and training set (GSE48424 includes 18 cases of PE and 18 non-cases) genes, and built a predictive model. The specificity and sensitivity are illustrated by receiver operating characteristic curves, and the stability was verified by two validation sets (GSE86200 includes 12 cases of PE and 48 non-cases, and GSE85307 includes 47 cases of PE and 110 non-cases). The results demonstrated that our predictive model shows good predictions, with an area under the curve of 0.991 for the training set, 0.874 and 0.986 for the validation sets. Finally, we found the 43 key marker genes in the model are closely associated with the clinically accepted predictive molecules, including FLT1, PIGF, ENG and VEGF. Therefore, this predictive model provides a potential approach for PE diagnosis and treatment.
Evaluation of the efficacy of signal-averaged electrocardiogram testing in the cardiac assessment of beta-thalassemia major patients
Authors: Bahmani Jahromi Maryam , Hassani Amir Hossein , Kasaei Mohammad , Hooshanginezhad Zahra , Aslani Amir , Zekavat Omidreza , Mortezaie Mohammad , Khosropanah Shahdad
Published: December 2022

Background

More than 70% of thalassemia’s major mortality is due to the cardiac complications of this syndrome, mostly consequent to myocardial Iron overload; therefore, evaluation of such complications is of utmost importance. T2*MRI is used to assess hepatic and myocardial Iron load in thalassemia patients, which is not always available. Signal-Averaged Electrocardiography is a rather easy method of evaluating major thalassemia patients regarding their risk for sudden cardiac death.

Methods and materials

In this cross-sectional study, 48 patients with thalassemia major underwent evaluation with electrocardiography, signal-averaged electrocardiography, echocardiography, T2*MRI, and ferritin level. The association of the existence of ventricular late potentials in SAECG and other cardiac variables was evaluated. Moreover, the association between myocardial and hepatic Iron load and cardiac characteristics was assessed.

Results

48 patients with a mean age of 30.31 ± 7.22 years old entered the study. 27 (56.3%) of the patients had ventricular late potentials, which were associated with myocardial dry Iron weight (P = 0.011). Nonspecific ST-T changes and premature atrial and ventricular contractions were seen more frequently in patients with late potentials (P = 0.002, 0.031, and 0.031, respectively). Patients with higher myocardial and hepatic Iron loads had longer QTc in their 12-lead surface electrocardiograms.

Conclusion

Patients with ventricular late potentials assessed by SAECG had a higher myocardial Iron load. Higher myocardial Iron load is associated with higher cardiac complications in patients with beta-thalassemia major; therefore, SAECG can be used as a screening test for cardiac complications in beta-thalassemia major patients.
Surgical treatment of Shone’s syndrome and patent ductus arteriosus in an adult
Authors: He Yanzhong , Jiang Yang , Wan Feng , Feng Xiaodong , Hua Yifei
Published: December 2022

Background

Shone’s syndrome is a rare complex congenital anomaly. The classical definition consists of four anomalies: supravalvular mitral membrane, parachute mitral valve (PMV), subaortic stenosis, and coarctation of the aorta (CoA). Few studies have been reported on Shone’s syndrome in adults, particularly the primary surgical correction of the anomalies.

Case presentation

A 22-year-old female patient presented with chest distress and tachypnea. Echocardiography and CT revealed supravalvular mitral membrane, PMV, Bicuspid aortic valve stenosis, CoA and patent ductus arteriosus. She underwent primary definitive surgical correction successfully and was discharged from hospital with symptoms free.

Conclusions

Our case report highlights the importance of echocardiographic evaluation in the diagnosis of Shone’s syndrome. The surgical strategy should be tailored according to both the patient’s profile and the surgeon’s personal surgical experience. Extra-anatomical bypass procedure is an appropriate technique for adult patients with long-segment coarctation and concomitant cardiac lesions. The outcomes of the case study indicate that the primary definitive surgery is encouraging.