bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Analgesic activity of Schiff base Coumarins with metal complex
Authors: Nimbal S. K. , Patil Manjunath , Ronad Pradeep , Kumar MR Pradeep
Published: October 2023

Purpose: The metal complexes of schiff bases have essential task during the field of chemistry and possess diverse pharmacological activities. Coumarin containing synthesized derivatives or plant extract may show analgesic effects Objective: Evaluating the analgesic activity of schiff base coumarins with metal complex. Materials and Methods: The study was conducted using Wister rats (150-250g) in both central and peripheral screening models of analgesics such as hot plate method, tail flick method (central) and writhing test (peripheral). The rats were pre administered with different derivatives of coumarins such as copper complex of schiff base of 2,5-dimethoxybenzaldehyde (Compound I), copper complex of schiff base of 4-dimethylaminobenzaldehyde (Compound II) and copper complex of the schiff base of 3-nitrobenzaldehyde (Compound III) for 14 days orally at the dose of 200mg/kg. Body weight, food and water consumption were continuously noted in chronic model. After the fourteen days rats were subjected to different screening models of pain and noted the reaction time. Gastro intestinal (GI) histopathological study was carried out to evaluate the GI toxicity. Results: Pretreatment with the different coumarin derivatives showed analgesic effect by increasing the reaction time to pain. In hot plate method, Compound II and III exhibited significant analgesic activity compared to Compound I whereas all three compounds showed significant increase in reaction time for tail flick method. In writhing test all compounds showed significant activity by reducing the pain perception induced by acetic acid. In histopathological study all compounds showed protective effect by reducing the ulceration and congestion of gastric mucosa. Conclusion: The screening model results and histopathological data evidently substantiate the analgesic effect of schiff base coumarins with metal complex.
Experimental Evaluation of Pippali, Vidanga and Tankana for Contraceptive effect
Authors: R. Kadibagil Vinay , Sarashetti R. S.
Published: October 2023

Since centuries women have been target of family planning measure and medicines. But chemical contraceptives are inherently unreliable and interfere with delicate and complex immunologicalreproductive system of women with high risk. This provided an opportunity to the research scholars to explore herbal contraceptive medicine. The concept of contraceptive is not a new to Ayurveda. Various contraceptives are mentioned in classical Ayurvedic texts. Such as 1) Pippali (Piper longum), Vidanga (Emblicaribes) and Tankana (SodiiBiboras). 2) Talisapatra (Taxus baccata) and Gairika (Hematite) with cold water and 3) Kanji (sour gruel) Bhavita(triturated) Japakusuma (Hibiscus rosa sinensis). The herbo mineral combination of Pippali (Piper longum), Vidanga (Emblicaribes) and Tankana (SodiiBiboras) was subjected for anti-implantation activity on albino rats by Choudhary and Khanna's method. Significant difference was noted in number of implantations, in weight of uterus and ovary in study group compared with standard group. Histological reports on isolated ovary reveals that study drug combination was suppressed the maturation of graffian follicle. Pippali, Vidanga and Tankana drug combination shown significant anti- implantation activity in albino rats and given further scope for clinical study which may contribute a better contraceptive medicine to female generation under national mainstream of health programme.
Exploring the Inhibitory role of Persicaria hydropiper bioactive compounds against 2KID protein associated with Staphylococcus aureus biofilm formation: Molecular Docking and Pharmacological property analysis
Authors: Majumdar Golak , Mandal Shyamapada
Published: October 2023

The current communication states the role of Persicaria hydropiper (L.) bioactive compounds in the inhibition of Staphylococcus aureus sortase A protein through bioinformatic approaches. The P. hydropiper-derived phytochemicals’ (kaempferol, winterin, isalpinin, quercetin, quercitrin, and confertifolin) 3D structures in .SDF format were retrieved from PubChem and were docked to Staphylococcus aureus sortase A (PDB ID: 2KID) protein, using AutoDock Vina in-built in Chimera. The crystallographic structure of the 2KID protein was obtained from RCSB protein data bank. The pharmacological properties of the phytochemical ligands were determined through Lipinski’s rule of 5, and ADMET analysis and bioavailability score prediction, using Swiss-ADME and pKCSM webservers. All the ligands displayed good affinity to 2KID protein, displaying binding energy ranging from -8.0 kcal/mol (kaempferol)) to -7.1 kcal/mol (confertifolin), compared to a conventional antibiotic, ciprofloxacin (binding energy: -6.7 kcal/mol). The protein-ligand interaction had hydrogen-bonds and different hydrophobic interactions. The phytochemical ligands obeyed Lipinski’s rule of five without any violation, except quercitrin. The bioavailability score for the ligands were 0.55, except quercitrin displaying the score of 0.17. All the ligands showed acceptable ADMET profiles. Hence, P. hydropiper bioactive phytochemicals might be useful in the development of drugs for the treatment against infection caused with biofilm forming Staphylococcus aureus.
Evaluation of Effect of Vitamin C on Streptococcus Mutans Induced Secondary Caries: An In vitro Study
Authors: G Nair Saumya , Kondody Rony T , Bhandari Sarita
Published: October 2023

This study aimed to assess and understand the protective effect of vitamin C against secondary caries formation around the margins of class V restorations with the help ofan in-vitro bacterial caries model. In this study, a total of 30 mandibular premolars were chosen and assigned to three groups (n=10). In this study, Class V composite restorations were prepared and along with pretreatment of the cavity walls with various solutions like Vitamin C (ascorbic acid solution), HEPES buffer solution and chlorhexidinedigluconate. After incubating specimens with Streptococcus mutans, dentin and enamel were assessed using Fluorescence Microscopy.The study showed Vitamin C (Ascorbic acid) inhibited the formation of secondary caries near the dentin resin interface. No inhibitory effects were observed in enamel margins. From the study, it could be concluded that the incorporation of ascorbic acid in the restorative procedure of resin composite may inhibit secondary caries formation. Neither the application of chlorhexidine nor HEPES buffer had much effect on the inhibitory effect on secondary caries.
VISION OF NURSES WORKING. VISION WITH DISABLED CHILDREN ABOUT THEIR PROFESSIONAL COMPETENCE
Authors:   Department of Health care, University Prof. Dr Asen Zlatarov, Burgas, Bulgaria., Obreykova Monika , Andonova Albena ,   Department of Health care, Faculty of Medicine, Trakia University, Stara Zagora, Bulgaria.
Published: October 2023

The nurse's work with children with disabilities requires narrowly profiled knowledge to ensure adequate medical and health care for children in the process of deinstitutionalization. Purpose: The purpose of the research is to establish the attitudes of nurses regarding the increase of their professional competence for working with children with disabilities in the process of deinstitutionalization. Methods: An anonymous survey was conducted of 109 nurses working in medical and social care homes (HMSCC) in the cities of Burgas and Stara Zagora. For this purpose, a questionnaire consisting of 34 questions of open and closed type was developed. Results: The survey found 68% of respondents believed that a nurse should have a continuous drive to learn new knowledge about caring for children with disabilities. The respondents (75%) indicate that dealing with emergency situations is a mandatory professional competence for those working with children with disabilities, another 55% consider that the ability to emotionally assess the child's condition is very important when performing their professional activity. The respondents considered that a personal contribution of the nurse (outside of professional duties) is necessary for the improvement of care for children with disabilities [t(107) = 5.814; p-level < 0.001]. Conclusion: The survey found a positive attitude of the respondents to participate in postgraduate studies. The respondents express a desire to become involved as trainers of parents to provide real knowledge and skills in order to deal with and solve the child's health problems that arise at home.
HIF Pathway Inhibition hold much promise and Point Toward an expanding RCC Armamentarium
Authors:   Editorial office, Kidney Cancer Journal, Pazhanisamy Senthil
Published: October 2023

The journey of Belzutifan towards the goal of getting its FDA approval for patients with refractory renal cell carcinoma has reached another milestone. The FDA has granted priority review to the supplemental new drug application (sNDA) for belzutifan. The sNDA seeks approval for the indication of patients with previously treated advanced renal cell carcinoma following immune checkpoint and anti-angiogenic therapies. The interim findings from LITESPARK-005(NCT04195750) demonstrates that the treatment with belzutifan led to a statistically significant and clinically meaningful improvement in progression-free survival (PFS) compared with everolimus in adult patients with advanced renal cell carcinoma whose disease progressed following PD-1/PD-L1 and VEGF tyrosine kinase inhibitor (TKI) treatments.
An Opportunity to Study Mechanisms of Palliative Care by Integrating into Management of The Treatment of Renal Cancer Carcinoma
Authors:   Section of Urologic Oncology Surgery, Rutgers Cancer Institute of New Jersey and      Rutgers Robert Wood Johnson  Medical School, Patel Hiren V. , Wilton Brandon ,   Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA, Singer Eric A. ,   Section of Urologic Oncology Surgery, Rutgers Cancer Institute of New Jersey and      Rutgers Robert Wood Johnson  Medical School, George Login ,   School of Nursing, Health Care Policy, and Aging Research, Rutgers University, New Brunswick, New Jersey, USA, Saraiya Biren ,   Division of Medical Oncology, Rutgers Cancer Institute of New Jersey and       Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey
Published: October 2023

Achieving patient-centered care requires helping patients understand their illness, eliciting patient values, and developing a collaborative care plan with input from patient and physician. Combining existing models in communication skills and shared decision making provides a road map for accomplishing these tasks in delivering patient-centered care. In this article, we highlight the importance of patient understanding of their prognosis as a key step in delivering patient-centered care. We then review literature suggesting that both patient and patient’s physicians’ emotions play an inhibitory role in accurate formulation and communication of prognosis by physicians and accurate incorporation of this information by patients. We postulate that the finding of benefit of early integration of palliative care (PC) in improving patient-centered outcomes may be addressing these inhibitory factors. Key skills of empathic communication by a PC team that is focused on addressing patient emotions may facilitate better understanding of prognosis and thus improved patient-centered decision leading to improved patient centered outcomes. Finally, we propose advances treatment of renal cell carcinoma makes it an ideal disease that can inform this hypothesis of how integration of PC works. Specifically, we propose that the curability potential in metastatic RCC, amplifies challenges associated with patient prognostic understanding and decision making. Studying which discipline – primary oncology team or palliative care team – can help patients achieve more accurate prognostic understanding leading to more patient centered choices and improved patient-centered care.
Constrictive Pericarditis induced by Human Herpes Virus Infection: A Case Report
Authors:   Southern Medical University, Guangzhou, 510080, China, Zhang Zhen , Yuan Haiyun ,   Southern Medical University, Guangzhou, 510080, China
Published: October 2023

Constrictive pericarditis represents a severe diastolic heart failure secondary to an inelastic and poorly compliant pericardium mediated by inflammation and fibrosis. It shows relative regional and temporal differences with respect to the etiologies.
Co-optimising Frequency-Containment Services from Zero-Carbon Sources in Electricity Grids Dominated by Renewable Energy Sources
Authors: MB Aimon
Published: October 2023

Power systems dominated by Renewable Energy Sources (RES) are characterised by reduced levels of inertia, which in turn threat the security of the electricity grid, and significantly increase the requirement for ancillary services such as inertia and Frequency Response (FR). Since inertia and FR are typically provided by part-loaded thermal generators, system security and carbon emissions are still highly coupled. Therefore, it becomes critical to investigate alternative ways to guarantee grid stability without resorting to polluting assets, as emissions targets would be unattainable otherwise. In this context, the present paper introduces a frequency-secured Stochastic Unit Commitment (SUC) model, which simultaneously co-optimises clean services such as inertia from Synchronous Condensers (SCs) and FR from part-loaded RES. A methodology is proposed to capture the dynamics for inertia from SCs and FR from RES in the form of linear constraints. The ancillary services dynamics are then mapped into the optimisation through frequency-security constraints obtained by solving the swing equation, eventually formulated as a Mixed-Integer Second-Order Cone Program (MISOCP). The proposed constraints enforce that sufficient ancillary services are scheduled to keep system stability, while taking advantage of the economic savings and emissions reduction from zero-carbon sources. Finally, to provide a rigorous quantification of the benefits of co-optimising the provision of zero-carbon ancillary services, a 2030 Great Britain (GB) power system scenario is used, demonstrating that ancillary services cost can be reduced from 45% to 4.2% of total system operating cost, and the emissions due to stability actions can be reduced from 57% to 2.6% of total system emissions.
Analysis of Trends of Research on Work-related Musculoskeletal Disorders using Text Mining
Authors:   Form of Public Safety and Culture, Lee Geon Hui , Choi Seo Yeon
Published: October 2023

Domestic musculoskeletal disorders have been on the rise since the 1997 IMF crisis, as rapid changes in work environments and practices, such as mechanization, automation, and specialization, have been implemented by various companies to enhance productivity. Furthermore, with increasing awareness and concern among workers, the government has been conducting harmful factor and causal investigations related to musculoskeletal disorders caused by burdensome work tasks through the amendment of Article 39 of the Industrial Safety and Health Act since 2003.
To ensure the proactive prevention of work-related musculoskeletal disorders and minimize work-related losses for workers' safety, there is a continuous need for systematic and comprehensive research. To address this, the present study conducted a trend analysis to explore new perspectives for preventing industrial accidents.
The literature collection comprised a total of 653 domestic theses and academic papers from 2003 to 2022 that included the keyword 'musculoskeletal disorder,' gathered through search engines such as the Korean Citation Index (KCI) and the Research Information Sharing Service (RISS). The data were categorized into two periods: the first period from 2003 to 2012 and the second period from 2013 to 2022. Text mining was employed to analyze the frequency (TF) and network connections, which were subsequently visualized.
The results revealed that the top keywords in work-related musculoskeletal disorder research throughout the entire period (2003 to 2022) were 'work,' 'musculoskeletal disorder,' and 'symptoms,' consistently recognized as essential research topics in both the first and second periods. In the first period, the most frequently discussed factors influencing workers' musculoskeletal disorders included 'posture,' 'physical condition,' 'environment,' 'job stress,' 'time,' 'age,' and the term 'survey' was prominent among the top keywords. In the second period, keywords like 'comparison,' 'development,' 'measurement,' 'method,' and 'investigation' emerged.
N-Gram analysis indicated that the simultaneous occurrence of the 'musculoskeletal disorder-symptoms' keyword was the most frequent throughout the entire period, followed by high frequencies of 'musculoskeletal disorder,' 'pain,' 'awareness,' and 'burden.' In the first period, body part-related keywords like 'hand-wrist,' 'shoulder-back,' 'wrist-finger,' and 'back-leg' were prominent. In the second period, keywords such as 'workload,' 'safety-health,' 'factor-investigation,' 'risk-assessment,' and 'occupational accident-insurance' were observed.
This study attempted the first analysis of theses and academic papers on work-related musculoskeletal disorders using text mining, a big data analysis method. The findings contribute to suggesting future research directions on work-related musculoskeletal disorders, holding significant implications for the field.
A Study on the correlation between chronic diseases of the elderly and human error in construction sites: Focusing on the mediating effect of lifestyle
Authors:   Form of Public Safety and Culture, Kim Hong Seob , Park Jong Yong , Hong Ha Na
Published: October 2023

In Korea, the number of elderly workers is increasing due to the aging population, and disasters caused by elderly workers are also increasing, resulting in about 49% of disasters and 63.6% of deaths in 2022. In order to reduce these elderly workers' disasters, we would like to study how human errors of elderly workers at construction sites are related to the individual health of workers. In particular, we would like to contribute to reducing disasters for elderly workers at construction sites by studying the relationship between chronic diseases that more than 40% of the Korean population experiences and about 80% of senior citizens aged 65 or older suffer from one or more.
This study aims to empirically study the effect of chronic diseases on human error at construction sites and the causal relationship between lifestyle-mediated effects of elderly workers in the construction industry. To statistically verify this, 286 workers were surveyed at 12 construction sites across the country. Among the collected data, 260 copies, excluding 26 unfaithful answers, were regression analyzed using version 2.3.28 of the self-hair ratio using R language.
The results of this study are summarized as follows.
First, it was confirmed that the first factor of lifestyle, ma1 (the number of drinking), ma2 (the amount of drinking), and ma7 (smoking), have no direct mediating effect when the independent variable, chronic disease, affects the dependent variable, human error. Second, it was confirmed that ma3 (sleep disorder) and ma4 (stress), two factors of lifestyle, have a direct mediating effect when chronic diseases, which are independent variables, affect human errors, which are dependent variables.
It has been verified that chronic diseases of elderly workers have a significant impact on human errors at construction sites, and in particular, sleep disorders and stress of elderly workers have been confirmed to have a positive effect on human errors. Thus, in addition to various measures in the workplace to reduce human errors so far, it is necessary to consider ways to contribute to reducing human errors in construction sites by paying attention to workers' health care measures such as improving the quality of sleep for elderly workers and stress reduction measures.
Assessing Selected Teaching Techniques and Their Impact on Student Success in the Classroom
Authors: Faith Timothy
Published: October 2023

Student success in college courses is important to students and faculty, though what variables predict student success are myriad and can be difficult to collect by faculty. Given the complex interaction of these variables, many of which are external to the classroom, a faculty member could be excused for thinking that the work of the faculty may not be impactful at all as to student success. However, this study considers several teaching techniques, including chunking course materials and assessments into smaller units, expanding practice homework assignments, and automating some course feedback to students through software, and identifies that increasing the number of exams that cover smaller portions of material appears to increase the average student pass rate of exams, but expanding homework and automating course/assignment feedback to students does not significantly impact student average exam grades. However, the use of intelligent agents did appear to negatively impact the rate at which students completed all exams in the course.
Landscape Approaches to Ecosystem Restoration: Lessons Learned from Managing Socio-Ecological Production Landscapes Seascapes
Authors: Nishi Makiko , Subramanian Suneetha M.
Published: October 2023

Landscape approaches help to effectively facilitate ecosystem restoration for the benefit of people and nature, by leveraging Indigenous and local knowledge and enhancing context-specific cooperation between stakeholders. The process of applying landscape approaches to ecosystem restoration should be multi-lateral, iterative and inclusive. It needs to be navigated by communicating and interacting with stakeholders across different sectors and levels. Recommendations: (i) start at the landscape or seascape scale to identify and mobilize local resources and capacities for long-term restoration efforts; (ii) promote peer learning and knowledge sharing to develop integrated solutions for restoration and sustainable development, and upscale them for broader impact; (iii) institutionalize local restoration efforts as part of coherent policies and frameworks to facilitate systemic change in human–nature interactions.
Implementierung eines E-Learning Kurses an der burgenländischen Feuerwehrschule
Authors: Stangl Ingemar , Schirmer Stefan
Published: October 2023

Durch den Einsatz von E-Learning und der Lernplattform Moodle hat die Landesfeuerwehrschule Burgenland in Zusammenarbeit mit zwei Studierenden der FH Burgenland die Voraussetzungen dafür geschaffen, dass landesweit etwa 4000 Feuerlehrleute alle eine Ausbildung innerhalb von wenigen Monaten absolvieren können, für die die Landesfeuerwehrschule ansonsten zehn Jahre lang Präsenzausbildung hätte durchführen müssen. Der Fokus lag dabei darauf, dass die Lernenden die Motivation bei der Absolvierung der Lernstrecke möglichst nicht verlieren und den Kurs so rasch wie möglich abschließen können. Dies wurde durch den gezielten Einsatz von Gamification-Elementen wie verschiedene Fortschrittsbalken, präzise gesteuerten Aufgabenketten und nicht zuletzt durch spezifisches Feedback bei den vorgeschriebenen Wissensüberprüfungen erreicht.
Akzeptanz von digitalen Informations-Tools bei Digital Non-Natives
Authors: Franc Elisabeth , Stampfl Rita , Futscher Fabian
Published: October 2023

Digitale Informations-Tools werden in allen Bereichen der Wissensübertragung und Informationsbeschaffung eingesetzt. Beginnend bei Ausbildungsinstituten bis hin zu privaten Unternehmen sind Mitarbeitende dieser Organisationen damit konfrontiert, derartige Tools für die jeweiligen Zielgruppen attraktiv zu gestalten. Bei dieser Gestaltung gilt es, zwischen der Zielgruppe der Digital-Natives und der Digital Non-Natives zu unterscheiden. Die Akzeptanz digitaler Tools ist seitens der Digital Non-Natives oft geringer als die der Digital Natives. Im Rahmen dieser Studie wurde aus diesem Grund der Frage nachgegangen, welche Faktoren die Akzeptanz digitaler Informations-Tools durch Digital Non-Natives beeinflussen. Verschiedene Technologieakzeptanz-Modelle, welche derartige Faktoren beinhalten, werden in dieser Studie diskutiert und in einem konkreten Fallbeispiel bei der Schaffung einer Informationsplattform in Form eines Online Help Centers angewendet. Diese Studie hat gezeigt, dass es wichtig ist, Akzeptanzfaktoren bei der Entwicklung von digitalen Informationsangeboten zu berücksichtigen und dass dadurch eine gesteigerte Akzeptanz des Angebots bei der Zielgruppe der Digital Non-Natives zu erwarten ist.
Ökologisch lesen im Fremdsprachenunterricht
Authors: Sippl Carmen
Published: October 2023

Das erklärte Ziel der österreichischen Lehrplanreform ist es, „die Lehrpläne für Österreichs Schulen zukunftsfit zu machen“. Dafür werden fachliche und überfachliche Kompetenzen fokussiert. 13 übergreifende Themen von gesellschaftlicher Relevanz sollen das vernetzte Lernen unterstützen. Dies betrifft auch die Bildungs- und Lehraufgabe des Fremdsprachen­unter­richts. Der folgende Beitrag widmet sich dem übergreifenden Thema „Umweltbildung für nachhaltige Entwicklung“ und hinterfragt seine Auslassung in den bis dato vorliegenden neuen Lehrplänen für die lebende Fremdsprache für die Volksschule und die Sekundarstufe I mit Blick auf die als Ziel gesteckte Zukunftsorientierung. Zur Füllung dieser Leerstelle wird das Konzept des Ökologischen Lesens zur Förderung von Futures Literacy vorgestellt, an einem Beispiel aus der russischsprachigen Literatur, und für die Integration in die Pädagog*innen­bildung empfohlen.
Rezension von: Raupp, Werner, Christian Gottlob Barth
Authors: Dinkel Thilo , Raupp Werner
Published: October 2023

Werner Raupp: Christian Gottlob Barth. Studien zu Leben und Werk. (Quellen und Forschungen zur württembergischen Kirchengeschichte, Band 16). Calwer Verlag Stuttgart 1998. 294 Seiten. Broschiert DM 98,- ISBN 3-7668-3579-3
Rezension von: Ferchl, Irene, Annette von Droste-Hülshoff am Bodensee
Authors: Schönhagen Benigna , Ferchl Irene
Published: October 2023

Irene Ferchl: Annette von Droste-Hülshoff am Bodensee. «Die zweite Hälfte meiner Heimat...». Ein literarischer Reiseführer. Klöpfer & Meyer Verlagsgesellschaft Tübingen 1997. 192 Seiten mit zahlreichen Abbildungen. Gebunden DM 34,- ISBN 3-931402-25-8
Features of the hemostasis system in cancer patients on program hemodialysis
Authors:   Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation (N.N. Blokhin NMRCO) Moscow Russia, Somonova Oksana V. , Elizarova Anna L. ,   Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation (N.N. Blokhin NMRCO) Moscow Russia, Gromova Elena G. ,   Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» оf the Ministry of Health of the Russian Federation (N.N. Blokhin NMRCO) Moscow Russia
Published: October 2023

The hemostasis system was studied in 35 cancer patients with comorbid terminal chronic renal failure (tCFR) before and after program hemodialysis (HD) at different stages of treatment. All patients underwent bicarbonate HD using equipment 4008 S ("Fresenius", Germany). Appropriate anticoagulation was performed according to the following scheme: at the beginning of the procedure, 1000-3000 units of sodium heparin were injected into the extracorporeal system; further in the process of extracorporeal hemocorrection operation the dose of sodium heparin was from 5 to 15 U/kg of body weight per hour. Hypercoagulability with signs of activation of intravascular blood coagulation, combined with impaired synthesis of individual coagulation factors, occurred in cancer patients with tCFR before the start of renal replacement therapy (RRT). All patients underwent HD procedure 3 times a week. After completion of the programmed HD procedure, multidirectional changes in the hemostasis system were observed. On the one hand, significant hypercoagulability with signs of intravascular coagulation activation remained, which increases the risk of thrombotic complications, on the other hand — prolongation of activated partial thromboplastin time (APTT), decreased activity of prothrombin complex factors and platelet aggregation ability increased the risk of hemorrhagic complications, which dictates the need for a cautious, balanced approach to the prescription of anticoagulants. According to Doppler ultrasonography (DU) in duplex mode of paired vessels (arteries or veins), no signs of thrombosis were detected. The mean hemoglobin level and platelet count before and after the programmed HD procedure did not differ. The use of programmed HD in cancer patients with tCFR, taking into account blood parameters, allows for adequate antitumor treatment, improves the quality and prognosis of life of cancer patients.
Preferences of practicing russian ophthalmologists in determining the treatment strategy forpatients with primary open-angle glaucoma (results of a multicenter scientific and analytical study)
Authors:   Mandryka Central Military Clinical Hospital Moscow Russia, Kuroyedov Alexander V. , Egorov Eugeny A. ,   Pirogov State National Research Medical University Moscow Russia, Gorodnichiy Vitaly V. ,   Mandryka Central Military Clinical Hospital Moscow Russia, Gaponko Olesya V. ,   Mandryka Central Military Clinical Hospital Moscow Russia, Grigoriev Dmitry V. ,   Mandryka Central Military Clinical Hospital Moscow Russia, Diordiychuk Svetlana V. ,   Mandryka Central Military Clinical Hospital Moscow Russia, Lovpache Jamilya N. ,   Pirogov State National Research Medical University Moscow Russia, Petrova Alina V. ,   Mandryka Central Military Clinical Hospital Moscow Russia
Published: October 2023

The aim of the study was to establish the preferences of domestic ophthalmologists in the selection of prescribing schemes and approaches in the treatment of patients with different stages of primary open-angle glaucoma (POAG). The results of a questionnaire survey of 472 ophthalmologists conducted during the period from August to November 2022 were analyzed. The main part of the questionnaire contained questions concerning the preferences of specialists in selecting the tactics of treatment of patients with glaucoma, for example, treatment schemes for patients with different stages of POAG, including priorities of particular prescriptions (groups of drugs and other approaches), details of current clinical practice — patients' compliance with the prescribed treatment and its cost, expediency of using combined antiglaucoma drugs in the form of their fixed combinations (FC), as well as preservative-free drugs. It was established that 328 (69.5%) ophthalmologists prefer to use the possibility of combined mechanism of action of antiglaucoma hypotensive drugs, 92 (19.5%) - the possibility of targeted influence on uveoscleral outflow. In patients with the initial stage of glaucoma the prescription of monotherapy with the use of prostaglandin analogs (PGAs) is used, in persons with the advanced stage of glaucoma the priority in the prescription of combined forms of drugs is determined, and at the highly advanced stage of the disease surgical treatment is performed. Polypragmasy in prescriptions of antiglaucoma topical drugs impedes effective treatment, and in this regard, ¾ of respondents were in favor of a more active use of FC drugs, considering their use more justified to achieve the goal of treatment than the use of separate prescription schemes. The use of preservative-free forms of drugs allows to keep the ocular surface of glaucoma patients intact for a long time, to predict the results of the expected (and imminent) surgical treatment and to increase the compliance to treatment. The results of the study indicate a confident adherence of ophthalmologists to the guidelines of current clinical recommendations when choosing drug regimens and treatment regimens in patients with different stages of glaucoma.
Use of stem cell-enriched fat grafts in facial reconstruction: have they demonstrated superiority over autologous fat grafting?
Authors:   School of Medicine, Universidad del Tolima, Ibagué, Colombia, Farley Reina Gonzalez Gerardo Jesus , Zambrano Arenas Maria Daniela del Pilar ,   School of Medicine, Universidad El Bosque, Bogotá, Colombia, Hernandez Cabarcas Daniel ,   School of Medicine, Universidad del Norte, Barranquilla, Colombia, Matiz German Daniel ,   School of Medicine, Universidad El Bosque, Bogotá, Colombia, Galvis Ballesteros Wilmer Giovanny ,   School of Medicine, Universidad de Pamplona, Pamplona, Colombia, Montalvo Clavijo Miguel Andres ,   School of Medicine, Universidad Ciencias Médicas de la Habana, La Habana, Cuba, Caicedo Rodrigo Alberto ,   School of Medicine, Universidad Libre, Cali, Colombia, Ortega-Sierra Michael Gregorio ,   Universidad Centrooccidental Lisandro Alvarado, Hospital Centro Antonio María Pineda, Barquisimeto, Venezuela
Published: October 2023

Since the 1990s, big strides have been made in plastic and reconstructive surgery, thanks to the implementation of new techniques and resources for its execution. In cases where restoration is sought for small defects, biosurgery, involving the utilization of stem cells, biomaterials, chemical engineering, and tissue engineering, can be employed. The potential to stimulate the innate regenerative capacity of tissue and generate a persistent response over time, minimizing surgical trauma and re-interventions, lies in stem cell transplantation. However, the evidence published on this matter is very scarce, leading to divergence of opinions, suggestions, and recommendations. The aim of this review is to analyze the most recent evidence concerning the outcomes of using fat grafts enriched with stem cells in facial reconstruction, as compared to autologous fat grafts. The review of the literature demonstrates a marked trend suggesting that fat grafts enriched with stem cells may be superior to autologous grafts in facial reconstruction, with potential benefits in medium-term volume retention and faster attainment of results.
Preface: 5th International Conference on Information Science and Electronic Technology (ISET 2023)
Authors: Eipstein Meredith , Mi Feiqiao
Published: October 2023

We are pleased to announce that the 2023 5th International Conference on Information Science and Electronic Technology (ISET 2023) was successfully held in Venice, Italy during August 26-27, 2023. The objective of ISET 2023 is to provide a platform for researchers, engineers, academicians as well as industrial professionals from all over the world to present their research results and development activities in information science, computer applications, mechatronics, electrical engineering, and electronic technology.

This conference provides opportunities for the delegates to exchange new ideas and application experiences face to face, to establish business or research relations, and to find global partners for future collaboration.

There were over 50 participants attended ISET 2023. During the conference, the conference model was divided into three sessions, including oral presentations, keynote speeches, and Q&A discussion. Their insightful speeches had triggered heated discussion in the conference. Every participant praised this conference for disseminating useful and insightful knowledge.

We would like to acknowledge all of those who have supported ISET 2023. Each individual and institutional help were very important for the success of this conference. Especially we would like to thank the organizing committee for their valuable advices in the organization and helpful peer review of the papers.

The Conference Scientific Committee

Venice, Italy
Prediction of Electric Load Neural Network Prediction Model for Big Data
Authors: Tu Teng , Ji Yihao , Chen Xuanyu
Published: October 2023

The problem of traffic enforcement scheduling has become one of the key concerns of the government in recent years. How to carry out scientific and efficient speed measurement activities to ensure the safety of road traffic has therefore become the direction of the article's research. The paper selects accident-prone and speeding-prone locations as checkpoints, dividing them into three zones. The optimal speeding check time period is determined to be 18:00-23:00. To increase officers' efficiency, the problem is transformed into a TSP and solved using the Immunity Algorithm. The article defines the degree of safety, based on prior speeding violations, and evaluates the effectiveness of the inspection routes. The persistent effect of the dispatch scheme on local road safety is analyzed, taking an average of 3.67 days for a road to reach a higher risk state. Monte Carlo simulations are used to model vehicle speeding events and officer enforcement, with a final speeding violation detection probability of 0.871.
A Study on Price Prediction of Used Sailboats Based on XG-Boost Algorithm
Authors: Song Linkang , Li Bangxu , Sun Xinyao , Dong Zhichen
Published: October 2023

The sailing industry is currently receiving more and more attention and there is a growing demand for sailboats. Their prices are constantly changing and inevitably contain useful trends and intrinsic correlations. Therefore, we developed a used sailboat price prediction model to allow relevant practitioners to better understand the sailboat market. First, we obtained some key data from the official websites of various sailboat manufacturers that may affect the price, including width, draft, displacement, sail area, headroom, and so on. We pre-processed the data. Next, based on the XG-Boost algorithm, we built a used sailboat pricing prediction model and estimated its accuracy, which reached about 91.5% in the test set. Finally, we did a one-way ANOVA on region and sailboat prices and found that there are significant differences in sailboat prices across regions. Therefore, we conducted a consistency test for region effects and found that the region effects for displacement and sail area were consistent.
Data Analysis of the Wordle Game: Insights and Predictive Models Based on Twitter Data
Authors: Jin Jiajun , Geng Buyi , Wu Sida
Published: October 2023

In 2022, the game "Wordle" gained immense popularity worldwide as players faced the challenge of guessing a five-letter word within six attempts, accompanied by feedback. This paper presents an extensive analysis of "Wordle" based on data mined from Twitter during the period from January 7 to December 31, 2022. The primary objective is to explore the game's dynamics and player engagement comprehensively.To achieve this, a sophisticated time-series model was developed to effectively track the fluctuation in the number of players. The model highlights an initial upward trend, reaching its peak on February 3, followed by a gradual decline and eventual stabilization, reflecting the sustained allure of the game. Additionally, this paper leveraged an XGBoost model to predict the distribution of player attempts, exhibiting remarkable accuracy, particularly for attempts ranging from three to six. This research demonstrates the powerful impact of data science in decoding intricate game dynamics and player behavior. Moreover, it emphasizes the fusion of gaming, data analytics, and social media as an exciting frontier for future research. The study's findings provide valuable insights into the gaming community's preferences and the underlying mechanisms that drive user engagement in digital gaming platforms.
Information Theory-based Wordle Game Word Difficulty Classification and Dynamic Planning Optimization Research
Authors: Gui Xin , Su Chen , Pan Keyu
Published: October 2023

Wordle has gained popularity as a word-guessing game. This study aims to describe the difficulty attributes of target words in Wordle and categorize them based on their difficulty. After two rounds of word guessing, this paper calculated the average mutual information for the third-round correct answers. This data was utilized to build a K-means classification model, categorizing words into three distinct groups: easy, normal, and hard. For instance, the word "EERIE" has an average mutual information of 8.997 bits, categorizing it as a word of 'hard' difficulty. Given the vast number of words to process, the computation time was extensive. To address this, this paper employed dynamic programming, leading to a significant reduction in operation time. Additionally, a Monte Carlo simulation model was established to simulate potential player guessing patterns, validating the classification model's robustness. The model developed in this research offers fresh perspectives on strategy selection in Wordle games and the difficulty assessment of target words. It serves as a dependable guide for game developers when classifying word difficulty.
Exploring Wireless Sensing Technologies and Their Applications in the Dawn of 6G
Authors: Wang Yubo
Published: October 2023

The recent advancements in communication technology have significantly fostered the development of wireless sensing technology. This burgeoning technology has found myriad applications in various fields like smart environments and indoor security, where the delivery of real-time and accurate data is pivotal. To comprehend the role of wireless sensing technology in the context of the forthcoming 6G revolution, it's essential to first understand its fundamental principles and key technologies. The basic concept of wireless sensing is to detect and interpret specific types of data (like temperature, motion, or sound) and transmit this information wirelessly to a device or system for analysis or action. Key technologies that underpin wireless sensing include sensor technology, wireless communication technology, and data interpretation algorithms. Reviewing the existing research, wireless sensing technology has evolved dramatically, with studies focusing on enhancing the quality and accuracy of sensed data, improving the reliability of wireless communication, and developing sophisticated algorithms for data interpretation. The utilization of machine learning and artificial intelligence has been a notable trend in recent studies, enabling more effective data interpretation and decision making.
Analysis of electromagnetic wave applications and development
Authors: Jin Zeyu
Published: October 2023

With the continuous advancement of science and technology, the variety of technological products around our lives has also increased, and many of them use the characteristics of electromagnetic waves. In order to make people better understand the relevant characteristics of electromagnetic waves, this article will systematically introduce the basic theory, classification, application and related safety issues of electromagnetic waves. Electromagnetic waves not only have a wide range of applications in daily life, such as communications, remote sensing and other fields, but also play an important role in military and medical fields. Although electromagnetic waves bring many conveniences, there are also certain safety risks. Therefore,understanding the nature and application of electromagnetic waves to better protect our health and promote scientific and technological progress is important. In addition, for the limitations and shortcomings of electromagnetic wave applications,  It is also crucial to explore potential development directions, in order to achieve comprehensive and efficient electromagnetic wave applications in the future.
The Advance of Internet of Things Security Threats and Possible Measures
Authors: He Beige
Published: October 2023

The Internet of Things (IoT) is a new stage of human informatization development after the Internet. With the IoT, physical devices can seamlessly exchange and process data with each other, further improving the human ability to process information. However, Internet of Things security research is still preliminary despite frequent data breaches and security incidents. This paper starts with the introduction of the IoT and introduces its definition, technical characteristics, and hierarchical architecture of the IoT. After that, the security threats that may be encountered at each layer are discussed, and finally, the ways to enhance the security of IoT. This paper aims to examine the security issues that arise in the IoT system and investigate the security measures that can be employed to serve as security technology guidelines for constructing secure IoT systems.
A review of low-temperature lithium metal battery research
Authors: Qu Jingchen
Published: October 2023

Rechargeable lithium metal batteries (LMBs) are one of the promising energy storage systems, which have the advantage of a high theoretical specific capacity of 3860 mAh/g and a low reduction potential of −3.04 V vs. SHE. With the development of society, the large use of batteries in low-temperature areas is inevitable. Typically, batteries fail at low temperatures, especially with temperatures below −20 °C, but the research on low-temperature behavior is limited. According to previous research on low-temperature lithium metal batteries, the main challenge is to suppress serious dendrite growth at low temperatures. Here, we reviewed the state-of-art progress of low-temperature LMBs, including protect layer, three-dimensional collector, and electrolyte. We found that most of the research works relate to electrolytes because a novel electrolyte can easily solvate, contribute to ion transportation, and be conducive to solid electrolyte interfacial (SEI) film formation, which can accelerate the kinetics at low temperatures, thus suppressing the serious dendrite growth at low temperatures. We propose that solid electrolytes can suppress the dendrite growth of LMBs at low temperatures effectively because solid electrolytes are not easy to be pierced.
Navigating the Creative Economy in the Wake of Pandemic and Digital Disruption: A Comparative Analysis of Korea and the UK
Authors: Peng Xiangrui
Published: October 2023

This article delves into the intricate landscape of the creative economy in the aftermath of the global pandemic and the pervasive influence of digital transformation. In particular, it conducts a comparative analysis between South Korea and the United Kingdom, shedding light on the contrasting strategies and outcomes within these two creative industry ecosystems.The creative economy's path to recovery is multifaceted, requiring adaptive strategies, government support, and digital transformation. The experiences of South Korea and the UK offer valuable insights into the dynamic and evolving landscape of the creative industry, poised to shape the future of culture and commerce.
On Radical of Neutrosophic Primary Submodule
Authors:   Department of Mathematics, Rajah Serfoji Government College (affiliated to Bharathidasan University), Thanjavur-613005, Tamilnadu, India, Vasuki M. ,   Department of Mathematics, Rajah Serfoji Government College (affiliated to Bharathidasan University), Thanjavur-613005, Tamilnadu, India,   Laboratory of Information Processing, Faculty of Science Ben M’Sik, University of Hassan II, Casablanca, Morocco,   Department of Mathematics, Rajah Serfoji Government College (affiliated to Bharathidasan University), Thanjavur-613005, Tamilnadu, India, Kumar P. Senthil , Broumi Said , Rajesh N.
Published: October 2023

In this paper, we introduce and study the concept of neutrosophic submodules and neutrosophic primary submodule with the help of the definition of a radical submodule, and we also study the properties of these submodules. Furthermore, homomorphic image and preimage of neutrosophic primary submodule are investigated.