bluuebunny/crossref_metadata_2025 huggingface dataset:
Traditional Chinese Medicine for Liver Cancer Treatment: Network Pharmacology Research
Authors: Zheng Shihao , Gu Yixiao , Qi Wenying , Wang Wei , Li Xiaoke , Zao Xiaobin , Li Size , Liu Shaoyu , Xue Tianyu , Ye Yongan , Liu Aimin
Published: January 2025

Background:

As one of the common malignant tumors nowadays, liver cancer has more
risk factors for its development and is characterized by a high recurrence rate, high mortality rate,
and poor prognosis, which poses a great threat to people's health. The specific efficacy of traditional
Chinese medicine is based on clinical practice, which is a high degree of generalization of
the characteristics and scope of the clinical effects of prescription medicines and a special form of
expression of the medical effects of the human body within the scope of traditional Chinese medicine.
Because of its multi-ingredient, multi-target, and multi-pathway characteristics, it has a great
advantage in the treatment of liver cancer. Still, at present, its specific molecular mechanism of
action has not yet been clarified.

Aim:

This study reviews the current status and characteristics of network pharmacology research
in the treatment of liver cancer, aiming to provide new ideas and methods for traditional Chinese
medicine treatment of the disease.

Methods:

This study was searched on the Web of Science and PubMed using keywords, such as
"traditional Chinese medicine", "liver cancer," and "network pharmacology." The citation dates of
the literature cited in this review are from 2000 to 2024.

Results:

The discovery of the key molecular mechanisms of traditional Chinese medicine in the
treatment of liver cancer through the network pharmacology approach and the in-depth study of
the related signaling pathways are conducive to a more in-depth exploration of traditional Chinese
medicine.

Conclusion:

Network pharmacology research plays a key role in the treatment and prevention of
liver cancer and deserves deeper exploration in the future.
Synthesis, Characterization, and Docking Studies of 1,4-dien as a Potential Impurity in Bimatoprost Drug
Authors: Guttikonda Nagarjuna Reddy , Venkatanarayana Muvvala , Haridasyam Sharath Babu
Published: January 2025

Introduction:

Bimatoprost synthesis, novel diene impurity, Pd/C, Docking studies, IFD calculations, prostaglandin.

Methods:

This impurity was controlled by employing 30% Pd/C, and the impurity level was brought to the permissible level, i.e., 0.03% (ICH guidelines) in the final drug preparation of Bimatoprost.

Results:

Finally, induced-fit docking calculations were performed to theoretically evaluate the binding efficiencies of these inhibitors in the crystal structure of Prostaglandin F syn-thase (PGFS).

Conclusion:

There are negligible differences in RMSD and docking scores between the two ligands, which amount to only 0.18 Å and 0.313 kcal/mol, respectively. These findings strongly indicate that both ligands are likely to exhibit similar biological functions and effi-ciencies.
Trends in Total Antioxidant Status and Other Biochemical Parameters in Type 2 Diabetes Mellitus: A Case-control Study
Authors: Al-Salman Remah Salih , Al-Ahmad Mohammad M. , Alameri Hiba
Published: January 2025

Objectives:

Owing to the existing evidence of the implication of oxidative stress in the
pathophysiology of type 2 diabetes mellitus (T2DM), the present study aims to investigate the correlation
of serum total antioxidant status (TAS) with comorbidities, various biochemical parameters,
and duration of T2DM. Various factors contributing to disease prevalence and trends in other
biochemical parameters are assessed.

Methods:

A retrospective observational study of 246 patients with T2DM whose data were retrieved
from the Proficiency Health Diagnostic Lab System in Al Ain. Data were analyzed using
the Statistical Package for the Social Sciences (SPSS) program.

Results:

The prevalence of T2DM was found to be higher in gender (male), age (≥45 years), ethnicity
(Middle Eastern), BMI (≥25), family history, and metabolic syndrome (hypertension and
dyslipidemia). TAS was found to be significantly higher in patients with comorbidities, than in
those without, particularly dyslipidemia and micro-albuminuria (p<0.05). TAS was weakly positively
correlated with various T2DM biochemical parameters (p<0.05), except for Fasting blood
glucose (FBG) (p=0.061). TAS was weakly negatively correlated with BMI (≥25) (p=0.042). Albumin-
to-creatinine ratio (ACR) was statistically higher in hypertensives than normotensives
(p=0.049). Duration of disease was only significantly correlated with ACR (r=0.325, p=0.001).
Uric acid levels were statistically higher in patients with microalbuminuria than in patients without
microalbuminuria (p=0.001).

Conclusion:

TAS was higher in patients with dyslipidemia and microalbuminuria, suggesting the
influence of other factors such as uric acid and lipid-lowering agents. TAS could be an important
factor in the management of T2DM cases. This needs to be further investigated in future studies to
fill the gap found in the literature.
Health Literacy and Numeracy in Self-monitoring of Capillary Glycemia: A Systematic Review of Mixed Methods
Authors: Medina Luis Angel Cendejas , Brandão Maria Girlane Sousa Albuquerque , Lima Glaubervania Alves , Zanetti Maria Lucia , Pace Ana Emília , Gallardo Maria del Pilar Serrano , Valverde Juana Mercedes Gutierrez , Oliveira Brena Shellem Bessa de , Lima Francisca Elisangela Teixeira , Teixeira Carla Regina de Souza
Published: January 2025

Objective:

The aim of this study was to synthesize scientific evidence on the influence
of health literacy and numerical knowledge on self-monitoring of capillary blood glucose.

Methods:

Adhering to the PRISMA guidelines and the principles of the Joanna Briggs Institute, a
comprehensive search was conducted across multiple databases, including CINAHL, Cochrane,
Embase, LILACS, PubMed, Scopus, Web of Science, Google Scholar, OPENGREY, and
NDLTD. The review included studies published in any language that examined the relationship between
HL, numeracy, and SMBG.

Results:

A total of 12 studies met the inclusion criteria. These studies utilized various assessment
tools, such as the Brief Test of Functional Health Literacy in Adults (B-TOFHLA) and the Diabetes
Numeracy Test (DNT-15), to evaluate health literacy and numeracy levels. The findings revealed
a significant association between adequate HL and numeracy and improved SMBG practices.
Specifically, individuals with sufficient health literacy were more likely to monitor their
blood glucose levels regularly and make appropriate treatment adjustments based on their readings.

Conclusion:

The results indicated that numeracy skills and health literacy are critical determinants
of effective SMBG, influencing the frequency and accuracy of self-care practices in diabetes
management. These findings highlight the urgent need for educational interventions tailored to enhance
these skills, which could lead to improved health outcomes for individuals with diabetes.
Synthesis and Biological Evaluation of Cyclohexane-1,2,3,5-Tetrol Analogs as Potential Lead Candidates for Cancer Therapy
Authors: Jayaraj Sujaritha , K Hemalatha
Published: January 2025

Introduction:

A preliminary biological evaluation of ten synthesized analogs, 5a-5j
{[5-(E)-benzylidene amino]-1,3,4-thiadiazol-2-yl} cyclohexane-1,2,3,5-tetrol, revealed promising
results, positioning these compounds as potential lead candidates for further optimization and
preclinical exploration in cancer therapy. Incorporating the 1,3,4-thiadiazol moiety into the structure
of the produced analogs considerably improved their anticancer activities, revealing the
compound's high potential for cancer treatment. Spectroscopic approaches and structural analysis,
such as elemental analysis, IR, ¹H NMR, ¹³C NMR, and MS, were crucial for properly establishing
the molecular structures of these analogs and evaluating their anticancer activity. These methodologies
laid a solid platform for rationally developing new anticancer medications with increased
efficacy and fewer adverse effects. Furthermore, computational tools like molecular
docking, ADMET prediction, and drug-likeness evaluation have accelerated the drug development
by finding the most promising lead candidates for preclinical and clinical trials. This technique
not only saves time and costs, but also raises the chances of producing successful anticancer
drugs.

Method:

The main aim of the current study is to develop, synthesize, in-silico, in-vitro potentials
of {5-[(E)-benzylidene amino]-1,3,4-thiadiazol-2-yl} cyclohexane-1,2,3,5-tetrol for a possible
anticancer drug to improve their efficiency and selectivity against cancer cells, computational
approaches aided in the rational design of these chemicals. Spectroscopic methods verified the
chemical structures of the target compounds. The structures show the presence of 1,3,4, thiadiazol
also responsible for anticancer activity. The 10 analogs were synthesized and showed encouraging
anticancer efficacy in preliminary biological evaluation, suggesting they might be suitable
lead candidates for more optimization and preclinical exploration

Results:

{5-[(E)-benzylidene amino]-1,3,4-thiadiazol-2-yl} cyclohexane-1,2,3,5-tetrol derivatives
5a-5j showed optimum IC50 values in invitro activity by SRB assay using MCF-7 as a strain, the
few selected analogs.

Conclusion:

The study synthesized cyclohexane-1,2,3,5-tetrol analogs and evaluated their potential
for cancer therapy. The compounds showed promising cytotoxic activity against various cancer
cell lines, with 5c, 5f, 5g, and 5j showing the most potent anti-proliferative effects. These
compounds induce apoptosis via mitochondrial dysfunction and cell cycle arrest. Further preclinical
investigations are needed to establish their therapeutic potential.
Computational Evaluation of Punica granatum Leaf Phytochemicals against Multi-drug Resistant E. coli: Molecular Docking, ADMET, MD Simulation, and DFT Studies
Authors: Mishra Shivam , Modanwal Shristi , Kumar Prabhat , Mishra Ashutosh , Mishra Nidhi
Published: January 2025

Introduction:

Multidrug-resistant (MDR) E. coli presents a significant challenge in
clinical settings, necessitating the exploration of novel therapeutic agents. Phytochemicals from
Punica granatum (pomegranate) leaves have shown potential antibacterial properties. This study
aims to identify and evaluate the efficacy of these phytochemicals against MDR E. coli.

Objectives:

This study aims to identify and evaluate the efficacy of most potential phytochemical
of Punica granatum leaf against MDR E. coli. through molecular docking, adme, toxicity,
molecular dynamic simulation, MMPBSA and DFT approaches.

Methods:

We performed molecular docking of 11 phytochemicals from the IMPPAT database
with four MDR E. coli targets: 1AJ6, 1FJ8, 4BJP, and 6BU3. Granatin B demonstrated the best
binding affinity and was further analyzed. ADME (Absorption, Distribution, Metabolism, and
Excretion) and toxicity analyses were conducted to assess its pharmacokinetic properties and
safety profile. Molecular Dynamics (MD) simulations were performed to evaluate the stability
of Granatin B with the targets. Finally, density functional theory (DFT) analysis was carried out
to understand the electronic properties and reactivity of Granatin B.

Results:

Granatin B exhibited the highest binding affinity among the 11 phytochemicals, indicating
strong potential as an inhibitor of MDR E. coli. ADME analysis revealed favorable
pharmacokinetic properties and toxicity analysis confirmed that Granatin B is non-toxic. MD
simulations showed stable interactions between Granatin B and all four targets. DFT analysis
provided insights into the electronic properties and reactive sites of Granatin B, supporting its
potential mechanism of action.

result:

Granatin B exhibited the highest binding affinity among the 11 phytochemicals, indicating strong potential as an inhibitor of MDR E. coli. ADME analysis revealed favorable pharmacokinetic properties, and toxicity analysis confirmed that Granatin B is non-toxic. MD simulations showed stable interactions between Granatin B and all four targets. DFT analysis provided insights into the electronic properties and reactive sites of Granatin B, supporting its potential mechanism of action.

Conclusion:

Granatin B from Punica granatum leaves is a promising candidate for treating
MDR E. coli infections. The integration of molecular docking, ADME, toxicity, MD simulations,
and DFT analysis underscores its therapeutic potential and paves the way for further experimental
validation and development as a novel antibacterial agent.
Effect of Self-management Intervention on Improvement of Quality of Life in Chronic Kidney Disease Patients: A Scoping Review
Authors: Pal Suchitra , Panduragan Santhna Letchmi , Said Faridah Mohd , Poddar Sandeep
Published: January 2025

Background

Chronic Kidney Disease (CKD) presents significant challenges globally, affecting health-related outcomes, quality of life (QoL), and healthcare expenditure. Self-management interventions are currently gaining importance as a means to empower the patients to manage their disease by themselves. However, currently there is a paucity of evidence evaluating its overall and proven role in patients with CKD. With this goal, we have designed this review to have a consensus on this aspect.

Objective

The objective of this study is to determine the effect of self-management interventions among patients with CKD who are not on renal replacement therapy (RRT).

Methods

This review was performed complying with the guideline set by the Preferred Reporting Items for Systematic Reviews and Meta-analyses extension for Scoping Reviews (PRISMA-ScR). Literature search was conducted using PubMed, Scopus, and ProQuest databases using the keywords “Chronic Kidney Disease”, “self-management intervention” and “Quality of Life”. Articles on patients with CKD not requiring RRT, published between January 2018 and December 2023, were included in this review. Articles such as dissertations, review articles, non-interventional studies, and those written in languages other than English were excluded. Out of the initially screened 17, 279 studies, 23 studies (including 3, 345 patients aged between 18 and 81 years) fulfilled our inclusion criteria were finally included in this review. Quality assessment and data extraction were conducted using Critical Appraisal Skills Program (CASP) and Mixed Method Appraisal tool (MMAT).

Results

Overall use of self-management interventions led to improvements in diet quality, psychological health, Health Related Quality of Life (HRQoL), self-management behaviors, and physiological and biochemical markers in patients with CKD. Nurse-led interventions, multidisciplinary approaches, and virtual care were found to be effective in enhancing self-efficacy and QoL.

Conclusion

Self-management interventions can significantly improve various aspects of health and QoL in CKD patients. Nurse-led and multidisciplinary approaches, as well as virtual care, are found to be effective strategies in this subset of patients who do not require RRT. Further research is needed to emphasize evidence and refine the interventions for broader application.
Strategy to Synthesize Kingianin: Biomimetic and Non-Biomimetic Approaches
Authors: Radzuan Siti Nurshahira Mohd , Mikhaylov Andrey A. , Azmi Mohamad Nurul
Published: January 2025

Kingianins are complex pentacyclic natural products isolated from the bark of Endiandra
kingiana. This article reviews synthetic routes for kingianins and their analogues. The reports of
five research groups are grouped in biomimetic and non-biomimetic approaches, featuring the use
of Diels-Alder and [2+2] ketene cycloaddition reactions. The most recent research by Six, Azmi et
al. reported the utilisation of [2+2]-ketene cycloaddition of key precursors for the synthesis of bicyclo[
4.2.0]octanes as key precursors of kingianins. This research demonstrates the advantages of ketene
chemistry by synthesising precursors. With this achievement, we look forward to extending
this method to the synthesis of additional bicyclo[4.2.0]octane analogues to achieve the total synthesis
of kingianins.
Thymol and Carvacrol as Potential Tocolytic and Anti-inflammatory Agents in Pregnant Rat Uterus
Authors: Muñoz-Pérez Victor Manuel , Pérez-Sánchez Aurora , Salas-Casas A Andrés , Ortíz Mario I.
Published: January 2025

Introduction:

This work aimed to evaluate the anti-inflammatory and myorelaxant effect of thymol (TM) and carvacrol (CAR) in the pregnant rat uterus. Both
compounds exhibit considerable antimicrobial, antispasmodic, and anti-inflammatory effects and due to these properties, they were studied in this
in vitro model of premature birth induced by infection.

Method:

All uterine tissues were studied in uterine contraction tests to determine the inhibitory effect of TM, CAR (10, 56, 100, 150, and 230 μM), and
nifedipine (a calcium channel antagonist) on phasic and tonic contraction induced by electro- and pharmacomechanical stimuli. The quantitative
determination of cyclic adenosine monophosphate (cAMP) induced by TM and CAR in the uterine lysate was carried out by ELISA. For the
determination of the anti-inflammatory effect of TM, the pro-inflammatory cytokine, interleukin (IL)-1β, in uterine samples stimulated with
lipopolysaccharide (LPS) was measured. Forskolin (FSK) was used as a positive control to evaluate the cAMP and cytokine levels. TM, CAR, and
nifedipine inhibited the uterine contractions at the highest concentration level, however, nifedipine was the most equipotent (p<0.05). In addition,
TM and CAR did not increase the intracellular cAMP production in comparison with FSK (p<0.05). However, both compounds were able to
decrease the LPS-induced production in a concentration-dependent manner that was considered statistically significant (p>0.05).

Results:

Finally, both the anti-inflammatory and uterine relaxing effects induced by TM and CAR were neither associated with the increase in cAMP levels
nor with the production of IL-1β in pregnant rat uterine samples. Therefore, TM and CAR can be considered as alternative adjuvants for the
treatment of infection-induced preterm labor. Before the in vitro experiments, an in-silico analysis was conducted using the Expaisy online server
to evaluate the biological effects of thymol on uterine contraction.

Conclusion:

It is crucial to know the interaction and identification of genes encoding the Voltage-dependent L-type calcium channel subunit alpha-1C proteins,
because of the functional relationship it may have in the inhibition of the uterine contraction. These properties place TM as a potentially safe and
effective adjuvant agent in cases of preterm birth, an area of pharmacological treatment that requires urgent improvement.
HOW RISK MANAGEMENT CAN BE IMPLEMENTED IN NEW AGRO-PRODUCT DEVELOPMENT (NAPD)?: A SYSTEMATIC LITERATURE REVIEW
Authors: Maulidina Lu'ayya Naila , Santoso Imam , Asmaul Mustaniroh Siti , Wafi'uddin Izzum , Choirun Annisa'u
Published: January 2025

New product development is highly complex because it integrates technical challenges from both internal and external sources. The potential for uncertainty or failure exists at every step of the product development process. One of the important tools to minimize risks in product development is risk management in new product development. This paper aims to review some research literature on the concept, process, and category of risk management in new agro-product development. This research uses a literature review analysis to analyze the concept and process of risk management in new product development. The articles were selected from Emerald, Elsevier, Springer, MDPI, and Taylor & Francis databases. The findings of this study demonstrate the critical role of risk management in minimizing risks associated with new product development through the implementation of diverse strategies. Risk management involves identifying, analyzing, evaluating, and treating risks. A variety of internal and external factors influence risk in product development. Internal factors are design, production, financial, management (organizational), marketing, market, technology, and supplier risks. External factors include suppliers, customers, and retailers outside the company. Many businesses, including small and medium-sized enterprises (SMEs), have adopted risk management to prevent product failures and financial losses. This paper provides a research framework for applying risk management to new agroindustrial product development.
The concept and essence of a joint will between spouses
Authors:   Radik Y. Zakirov Kazan Branch of the Russian State University of Justice, Zakirov Radik Y. , Rizvanova Ekaterina M. ,   Ekaterina M. Rizvanova Kazan Branch of the Russian State University of Justice
Published: January 2025

В статье рассматриваются ключевые моменты такого элемента российского наследственного права как, совместное завещание супругов. Авторами отмечено, что внедрение совместного завещания супругов в систему российского наследственного права представляет собой значительное укрепление их правового статуса при переходе наследства. Это новшество предоставляет супругам расширенные возможности для осуществления их воли, отражая растущее значение семейных ценностей и равноправия супругов в современной России. Также, по мнению авторов, это отражает адаптацию к изменяющимся социальным условиям и потребностям граждан, являясь актуальным и важным элементом наследственного права, который отвечает на общие тенденции развития частного права и социокультурных изменений в стране.
The Federal Bailiff Service as a body for the enforcement of decisions: problems of the exercise of powers
Authors:   Saida N. Keramova Dagestan State University, Keramova Saida N.
Published: January 2025

В статье рассматриваются проблемы реализации полномочий должностными лицами Федеральной службы судебных приставов, а также вопросы, касающиеся нормативно-правового регулирования деятельности данного органа принудительного исполнения. Перечисляются особенности функционирования Федеральной службы судебных приставов на российской территории, основные задачи и функции данного государственного органа власти. Анализируются последние изменения в российском законодательстве, касающиеся Федеральной службы судебных приставов. Приводятся примеры из судебной практики. Делаются выводы о том, что, несмотря на внесение изменений в законодательство, по-прежнему наблюдается несовершенство его нормативной правовой базы, что сказывается на эффективности работы судебных приставов. Формулируются предложения, направленные на ее оптимизацию.
Historia de las carreteras en el Perú, 1896-2024
Authors: Pérez Baylón Mauricio Javier
Published: January 2025

Las carreteras juegan un papel muy importante en la economía peruana, pues son las arterias que transportan los flujos de bienes y personas por todo el territorio nacional. Si bien hoy el país cuenta con una importante red de carreteras, constituirla no ha sido tarea fácil. Estas dificultades han sido causadas tanto por factores inherentes, como la compleja geografía, como por factores contextuales, como las crisis económicas y políticas. Por otro lado, además de difícil, el proceso de constitución ha sido largo y, por si fuera poco, sigue vigente. Asimismo, los actores involucrados han sido varios, pero pueden reducirse a dos: el sector público y el sector privado. En ese sentido, los inicios de la constitución de la red de carreteras en el Perú republicano se remontan a 1896, con la creación del Ministerio de Fomento. Más adelante, este sería reemplazado por el Ministerio de Transportes y Comunicaciones, pero el rol del sector público seguiría siendo predominante. El cambio se sentiría recién en 1990 con la liberalización de la economía peruana. De ahí en adelante, el sector privado tendría una participación cada vez más activa y tenaz en la construcción y operación de carreteras.
Early oral anti-inflammatory diet in patients with mild acute pancreatitis：study protocol for a randomized controlled trial (Preprint)
Authors:   XueYang,   Hairong Lin, Guirong Li Gui-rong ,   Hong Li,   Xin Zeng,   Xin Zhou,   Li Zhang
Published: January 2025

BACKGROUND

Early oral feeding in patients with mild acute pancreatitis can facilitate early recovery and offer economic benefits such as reduced average length of hospital stay and hospitalization costs. However, there is a paucity of research on nutritional support protocols for early oral feeding in patients with acute pancreatitis. Anti-inflammatory diets have been shown to decrease inflammatory levels and modulate intestinal microbiota, which may confer advantages in early nutritional support for patients with acute pancreatitis.

OBJECTIVE

This study aims to explore the safety and effectiveness of early introduction of an anti-inflammatory diet in patients with mild acute pancreatitis.

METHODS

This is a single-center randomized controlled trial where the experimental group undergoes early oral anti-inflammatory diet intervention, while the control group receives conventional nutritional management. The primary outcome measures include levels of inflammatory biomarkers (C-reactive protein,interleukin-6, interleukin-10, and tumor necrosis factor-α, nutrition-related indicators (BMI, body composition, albumin, and prealbumin), and gut microbiota. Secondary outcome measures include the average length of hospital stay and average hospitalization costs.

RESULTS

The enrollment of study participants commenced in December 2024, with an anticipated completion date in July 2025. A comprehensive final analysis of the study outcomes is planned for October 2025, following the collection and rigorous evaluation of all relevant data.

CONCLUSIONS

The positive findings of this study may offer novel clinical practice guidelines for early nutritional support in patients with mild acute pancreatitis.

CLINICALTRIAL

Chinese Clinical Trial Registry.gov ChiCTR2400094056；https://www.chictr.org.cn/index.html
TO STUDY THE PROFILE OF BACTERIAL INFECTIONS IN END-STAGE RENAL DISEASE PATIENTS ON MAINTENANCE HEMODIALYSIS
Authors: SEJSHI LATVOSHI  , VEENU GUPTA  , VIKAS MAKKAR  , MANISHA AGGARWAL
Published: January 2025

Objectives: The aims and objectives of the study are to characterize bacterial infections in end-stage renal disease (ESRD) patients on maintenance hemodialysis.
Methods: This forward-looking study was carried out over the course of 1 year in the Microbiology Department. Data were collected in pre-structured proforma, which included demographic details, risk factors, investigations, laboratory parameters, follow-up, and outcomes. Samples were collected on the basis of clinical suspicion and processed according to standard protocols. Identification and antimicrobial-susceptibility of bacterial isolates were done by BACTEC and VITEK I/D system.
Results: A total of 673 cases were enrolled, out of which 166 had bacterial infections. There was an overall male preponderance (68%), and the most common age group was 61–70 years (30.1%). A total of 225 infections were observed in 203 episodes. Most common infection was urinary tract infection (54.3%). The majority of the isolates were Gram-negative bacteria (77.3%), out of which Klebsiella pneumoniae (36.3%) was most common. Gram-negative isolates demonstrated highest susceptibility to amikacin, gentamicin, and cefoperazone+sulbactum.
Conclusion: Infections in ESRD patients on maintenance hemodialysis are prevalent and significantly impact morbidity and mortality. Identifying infection profiles can aid in targeted interventions and improve patient outcomes.
Understanding COVID-19 Vaccine Hesitancy in Nigeria Through University Community Lens
Authors: Madu Cajethan Okechukwu
Published: January 2025

It is widely acknowledged that vaccination represents one of the greatest advances in public health in human history. Nonetheless, vaccine rejection or hesitancy is a public health issue that has continuously thwarted coordinated attempts by health officials to stop the spread of infectious diseases like the Coronavirus in Nigeria. It is critical to assess public perception, which will encourage vaccine acceptance through focused initiatives. Therefore, this study assesses vaccination reluctance among the Benue State University student community. A cross-sectional descriptive design was used in the study. A questionnaire was distributed to 150 participants, selected through the convenience sample technique. SPSS was used to enter and analyse the data. Eighty-seven percent of the respondents were between their first and third years, and the majority (63%) were over 18-30. Only 68% of the respondents thought the virus was real.Additionally, none of the students had a favourable disposition towards the vaccination. The respondents cited fear of vaccine side effects (46.2%), distrust of the government (33.9%), vaccine efficacy (12.5%), and a variety of mystical possibilities (7.4%) as the major causative factors behind their hesitation to receive the vaccination. Available data show a serious communication breakdown between the respondents and the regional health authority. To improve public acceptance of the COVID-19 vaccine, broad and focused public health promotion initiatives are needed to alleviate some public concerns.
Agenciamientos artísticos: re-pensar la agencia de los trabajos artísticos desde una mirada interdisciplinaria
Authors: Ribeiro Cavalcanti Raíza
Published: January 2025

En este artículo, pretendo realizar una revisión de mi tesis doctoral sobre la agencia de los trabajos artísticos, casi diez años después, actualizando esta premisa sociológica para complejizarla. Con sustento en lo anterior, buscaré elaborar cómo, a partir de nuevas investigaciones desde y con lo visual, percibí otras potencias presentes en la agencia de los trabajos artísticos, los cuales aluden no solamente a lo discursivo, sino a los imaginarios, a la dimensión interagencial y hasta a reflexiones sobre el Antropoceno. Estas nuevas cuestiones puestas por los trabajos artísticos, me llevan a buscar comprender sus agencias no solamente al nivel de su circulación en el espacio institucional, sino, igualmente, a observar cómo estos son productores de potencias imagéticas en una disputa por imaginarios de futuro. La conclusión de esta reflexión es pensar cúal es la sociología del arte en la cual estoy interesada realizar en la actualidad: una con necesidad tanto de un intenso y amplio debate interdisciplinario como de una metodología que considere no solo lo discursivo/semiótico, como la imagen en sí, comprendiendo lo visual como ente/ser capaz de acción/transformación social desde sus propias materialidades.
Enseñanza del pensamiento sistémico de la Tierra. Evidencias del aprendizaje activo y propuesta de un modelo De capítulo para el “Atlas Interdisciplinario de México”
Authors: Becerra-Torres Eduardo , Bravo-Pérez Oscar
Published: January 2025

La Tierra, la sociedad y el ambiente están encarando en los últimos años fuertes crisis climáticas, energéticas, alimenticias e hídricas. En la formación académica esta circunstancia obliga a los docentes a formar profesionales capaces de entender la importancia de la interdisciplinariedad y la transdisciplinariedad y de la aplicación de los conocimientos que con ellas se adquieren en la resolución de  problemas multivariables en sistemas complejos. La enseñanza de las Ciencias de la Tierra debe implementar técnicas de docencia  innovadoras y estimulantes que permitan desarrollar el Pensamiento Sistémico de la Tierra (PST). Los docentes que abordan los temas  el Sistema Tierra deben tener claro que el estudiantado está conformado por personas con perfiles heterogéneos y académicos  diversos y, en consecuencia, utilizar las técnicas de enseñanzaaprendizaje tradicionales, discursivas y unidireccionales reduce las   posibilidades de adquirir habilidades de orden superior como el análisis, la síntesis y la resolución de problemas. En este trabajo  presentamos un modelo de capítulo para el “Atlas Interdisciplinario de México” utilizando datos de un estudio sobre la Cuenca de  Serdán-Oriental con actividades conducidas que permiten el ejercicio del pensamiento sistémico transdiciplinario con vistas a la  formación de profesionales capacitados para contribuir a la solución de los problemas globales que enfrenta la sociedad. Asimismo,  presentamos los resultados de la intervención educativa durante el 2022 que demuestran que la aplicación de este modelo de  enseñanza estimula el aprendizaje autónomo y la resolución de problemas complejos, con miras a cumplir el objetivo de una educación de calidad y la reducción de desigualdades.
La utilidad de los sensores de bajo costo en las Geociencias: Caso de estudio para la detección de tormentas geomagnéticas
Authors: Rodríguez-Trejo Alejandro , Ibarra-Ortega Héctor E. , González-Guzmán Reneé
Published: January 2025

El desarrollo y uso de sensores de bajo costo en combinación con sistemas de microcontroladores como los Raspberry Pi, Arduino y ESP32 ha abierto nuevas posibilidades para el campo de las geociencias, ofreciendo soluciones accesibles y flexibles para el monitoreo y análisis de fenómenos naturales. Estas plataformas permiten la creación de sistemas de monitoreo adaptables y personalizables capaces de registrar diversos parámetros ambientales como temperatura, presión, humedad y variaciones del campo geomagnético. Este artículo explora el uso de estas tecnologías en las geociencias, enfocándose en su aplicabilidad y ventajas, destacando principalmente su bajo costo y versatilidad. En este trabajo se detalla la metodología de desarrollo de una estación meteorológica mediante el uso de un microcontrolador ESP32 y un sensor BMP280, detallando la metodología de conexiones y cableado físico así como la programación del microcontrolador. También, a través de un caso de estudio centrado en la detección de tormentas geomagnéticas, se utilizaron un ESP32 y un magnetómetro HMC5883L con el objeto de mostrar sus aplicaciones prácticas tanto en contextos académicos como en proyectos comunitarios. El ejemplo pone de manifiesto el potencial de estas herramientas para realizar investigaciones preliminares en lugares con recursos limitados o como introducción a conceptos avanzados en geociencias. A pesar de la limitante de los sensores de bajo costo en comparación con la gran precisión de los equipos de alta gama utilizados en laboratorios especializados, los primeros ofrecen una excelente oportunidad para realizar investigaciones exploratorias, proyectos educativos y la extensión de redes de monitoreo en áreas donde la infraestructura tecnológica es limitada. La facilidad de integración y programación, junto con la gran cantidad de documentación disponible, hacen que estas tecnologías sean ideales para científicos, educadores y estudiantes, facilitando el acceso a herramientas que de otro modo estarían fuera de su alcance. De este modo, estos sistemas representan una valiosa contribución para el avance de las ciencias de la Tierra y su difusión en sectores más amplios de la sociedad.
explotación del hombre por el hombre: Una intersección entre Derecho, Ética y Filosofía
Authors: Turner Tarango Jesús Enrique
Published: January 2025

En la historia del pensamiento jurídico y filosófico, la dignidad humana ha surgido como un principio rector en la interpretación y aplicación de las leyes. Desde la ratificación de la Convención Americana sobre Derechos Humanos en 1969 hasta debates recientes sobre la explotación financiera, se han realizado esfuerzos para salvaguardar derechos fundamentales y promover la justicia social. Se ha establecido un diálogo entre la teoría jurídica y la realidad social, generando conceptos como el derecho a una vida digna y el principio de progresividad de los derechos humanos. La jurisprudencia y la doctrina jurídica se han entrelazado con la filosofía moral para abordar cuestiones complejas como la explotación económica, subrayando la necesidad de una vigilancia constante y una aplicación rigurosa del derecho. Este diálogo busca construir un orden jurídico justo, equitativo y respetuoso de la dignidad humana, prohibiendo la explotación del hombre por el hombre en todas sus formas.
Análisis deconstructivo de la Jurisprudencia P./J. 20/2014 (10a) de la Suprema Corte de Justicia de la Nación relativa a los tratados internacionales en materia de derechos humanos
Authors: Herrera Pérez Alberto
Published: January 2025

Las reformas a la Constitución Política de los Estados Unidos Mexicanos del año 2011 significaron un parteaguas en el tema de los derechos humanos al reconocer al más alto nivel del orden jurídico mexicano el espectro tutelar de los tratados internacionales donde el Estado mexicano es parte. La Suprema Corte de Justicia de la Nación emitió criterio jurisprudencial sobre el lugar que ocupan estos instrumentos supranacionales en el orden jurídico mexicano apartándose, para este efecto, de los principios tradicionales de jerarquía normativa y supremacía constitucional.
instabilidade política na Bolívia e a ameaça ao novo constitucionalismo democrático latino-americano
Authors: Horta Rezende Renato
Published: January 2025

O novo constitucionalismo democrático latino-americano busca maior participação popular e reconfirmação de grupos historicamente excluídos. A Constituição da Bolívia, promulgada em 2009, é um ícone desse paradigma. No entanto, o país enfrenta desafios devido à resistência a dois factores reais de poder e ao autoritarismo histórico. Nenhum presente trabalho é apontado como problema de pesquisa, as instituições bolivianas têm conseguido manter a estabilidade política no país, sendo investigadas com hipóteses negativas influenciadas por fatores reais de poder. A pesquisa utilizou o método científico hipotético-dedutivo, tendo como referencial teórico conceitos levantados por Ferdinand Lassale. A hipótese foi parcialmente confirmada.
ley de Dios o la ley de los seres humanos: delitos sexuales cometidos por ministros de culto religioso
Authors: Luján Luján Karina
Published: January 2025

En este artículo se expone cómo ha evolucionado en México, principalmente en las últimas décadas, las sanciones penales relativas a delitos cometidos por ministros de culto religioso, lo cual ha ido de la mano con las demandas públicas de víctimas que alzaron la voz en búsqueda de justicia tanto civil como de la iglesia. Asimismo, se analiza cómo no es un trabajo terminado lograr empatar el derecho penal con las disposiciones eclesiásticas. Para efecto de este estudio, se examina el caso del Derecho Canónico, por ser la regulación que más conocemos en nuestro sistema latinoamericano. Finalmente, se reflexiona sobre cómo garantías fundamentales entran en juego, como el doble enjuiciamiento o la imprescriptibilidad de los delitos, privilegiando el derecho de las víctimas a un resarcimiento del daño sufrido por hechos delictivos que sucedieron, principalmente, durante su infancia.
derecho al honor de los parlamentarios españoles: mecanismos de defensa
Authors: López López María Victoria
Published: January 2025

El derecho fundamental al honor se encuentra proclamado en el artículo 18.1 de la Constitución Española de 1978. Este derecho se configura como uno de los elementos fundamentales de la configuración de nuestro Estado democrático por su íntima relación con lo proclamado en los artículos 1.1 y 20 de la CE. Por ello, este trabajo pretende abordar cuestiones tan relevantes del honor como la titularidad del mismo por los personajes públicos, en concreto los parlamentarios y su relación con el derecho a la información y la libertad de expresión previstos ambos como límites a la protección del derecho al honor, así como los mecanismos de defensa protectores ante las injerencias a las que se encuentran sometidos los parlamentarios y políticos españoles.
Control político sobre el control constitucional en Bolivia
Authors: Montenegro Caballero Dora
Published: January 2025

En 2009, Bolivia introdujo en su Constitución la elección de autoridades judiciales por voto popular, siendo el primer país en hacerlo. Sin embargo, esto ha generado problemas, como la falta de elecciones judiciales en 2023 para reemplazar a las autoridades elegidas en 2017. Para solucionar la situación, la Asamblea Legislativa propuso una ley que suspendía los plazos procesales y el funcionamiento de las cortes hasta la elección de nuevos jueces. No obstante, el Tribunal Constitucional Plurinacional declaró inconstitucional esta suspensión, extendiendo el mandato de las autoridades actuales. En respuesta, el Legislativo aprobó la Ley 075, anulando parcialmente esta decisión del Tribunal.
Quiñónez de Huizar, Francisco Rubén, Sistema Jurisprudencia y el precedente obligatorio en México, México, Editorial Ubijus, 2023
Authors: Orduña Trujillo Eva Leticia
Published: January 2025

La obra se aboca al análisis del sistema jurisprudencial en su sentido amplio: conceptual, histórico y técnico jurídico. En particular estudia el sistema jurisprudencial de México y la reforma realizada en 2021 al Poder Judicial Federal.  En este último sentido, toma en cuenta la importancia y alcances del precedente obligatorio. El libro se compone de ocho capítulos: 1) Jurisprudencia y sistema jurídico, 2) La jurisprudencia en el derecho continental y en el common law, 3) Los orígenes del precedente judicial en México, 3) la jurisprudencia histórica, 4) El sistema de precedentes en la constitución de 1917, 5) La jurisprudencia vigente de 1919 a 2021, 6) La jurisprudencia en el sistema jurídico mexicano, 7) La naturaleza de la jurisprudencia, el nuevo paradigma de la jurisprudencia, 8) Elaboración y publicación de las tesis jurisprudenciales.
Ríos Ruiz, Alma de los Ángeles, Actualidad de los sistemas jurídicos contemporáneos y las tradiciones legales, México, DIKAIA, 2024
Authors: Patiño Manffer Ruperto
Published: January 2025

El libro Actualidad de los sistemas jurídicos contemporáneos y las tradiciones legales de la Dra. Alma de los Ángeles Ríos Ruiz es una obra académica que ofrece un análisis profundo y detallado de los sistemas jurídicos más influyentes en el mundo actual. La autora, con su vasta experiencia y conocimiento, proporciona una visión integral y comparativa de las distintas tradiciones legales, destacando sus características, evolución y particularidades.
The Role of Artificial Intelligence (AI) in Improving Inventory Management and Demand Forecasting in the E-Commerce Sector: Research on Bangladesh Perspective
Authors: Shahriar Ashraf
Published: January 2025

The rapid growth of e-commerce in Bangladesh has created significant opportunities for businesses to expand their
reach and serve a larger customer base. However, challenges such as inefficient inventory management, inaccurate demand
forecasting, and logistics inefficiencies continue to hinder the sector's growth and profitability. Artificial intelligence (AI) offers
an innovative solution to address these challenges by enabling data-driven decision-making, real-time monitoring, and predictive
analytics. This study investigates the role of AI in improving inventory management and demand forecasting in Bangladesh's ecommerce environment. The study examines how AI technologies such as machine learning, predictive analytics, and
automation can optimize inventory levels through more accurate demand forecasting, reduce operational costs, and improve
customer satisfaction. By analyzing current practices in Bangladesh's e-commerce industry, the study identifies key gaps in AI
adoption and highlights barriers such as lack of infrastructure, high implementation costs and limited technical expertise.
Furthermore, the paper examines success stories of AI adoption in global e-commerce markets and assesses their applicability to
Bangladesh. The results indicate that AI-powered inventory and forecasting systems can significantly improve the efficiency and
competitiveness of e-commerce enterprises in Bangladesh. However, collaboration among stakeholders, investments in AI
infrastructure and capacity building are essential to achieve these benefits. The study concludes with practical recommendations
for integrating AI solutions in Bangladesh's e-commerce ecosystem and highlights the need for policy support and technological
advancements to foster sustainable growth.
Ethical Concerns in Large-Scale Data Labeling and Usage: Challenges and Solutions
Authors: Ammar Ammar Ali , Houssein Alhoussein I , Abusbaiha Ali Mohammed
Published: January 2025

Abstract: The rapid adoption of artificial intelligence (AI) and machine learning (ML) has created an unprecedented demand
for high-quality labeled data. Large-scale data labeling, a critical component of AI system development, often involves vast
datasets sourced from diverse populations and annotated using a combination of automated processes and human labor.
However, the ethical challenges associated with these practices have gained significant attention. This paper explores key ethical
concerns in large-scale data labeling and usage, focusing on four critical areas: bias, privacy, labor practices, and transparency.
Bias in labeled data, arising from the inherent subjectivity of annotators and the unrepresentative nature of many datasets,
exacerbates the risk of unfair or discriminatory outcomes in AI applications. Privacy violations occur when sensitive
information is collected or used without proper consent, often challenging the effectiveness of anonymization techniques.
Furthermore, the reliance on crowdsourced labor for data annotation raises concerns about worker exploitation, low
compensation, and the mental toll of labeling sensitive or explicit content. Lastly, the lack of transparency and accountability in
data collection and labeling processes undermines public trust and ethical standards.
Through a comprehensive review of existing practices, this paper highlights real-world case studies and controversies, including
biased datasets and privacy violations. Current technological and policy-driven solutions—such as privacy-preserving
techniques, labor reforms, and bias mitigation algorithms—are critically examined. Finally, the paper discusses the challenges
of implementing these solutions at scale and identifies future research directions. By addressing these concerns, this work aims
to promote more equitable, transparent, and ethical practices in the lifecycle of AI data management.
Response to "The measurement postulates of quantum mechanics are not redundant"
Authors: Masanes Lluís , Galley Thomas D. , Müller Markus P.
Published: January 2025

Adrian Kent has recently presented a critique \cite{Kent} of our paper \cite{MGM} in which he claims to refute our main result: the measurement postulates of quantum mechanics can be derived from the rest of postulates, once we assume that the set of mixed states of a finite-dimensional Hilbert space is finite-dimensional. To construct his argument, Kent considers theories resulting from supplementing quantum mechanics with hypothetical ``post-quantum'' measurement devices. We prove that each of these theories contains pure states (i.e. states of maximal knowledge) which are not rays of the Hilbert space, in contradiction with the ``pure state postulate'' of quantum mechanics. We also prove that these alternatives violate the finite-dimensionality of mixed states. Each of these two facts separately invalidates the refutation. In this note we also clarify the assumptions used in \cite{MGM} and discuss the notions of pure state, physical system, and the sensitivity of the structure of the state space under modifications of the measurements or the dynamics.