bluuebunny/crossref_metadata_2025 huggingface dataset:
Statistical Evaluation of the Temperature Forecast Error in the Lower‐Level Troposphere on Short‐Range Timescales Induced by Aerosol Variability
Authors: Yamagami A. , Kajino M. , Maki T.
Published: June 2022

This study statistically evaluated the aerosol impact on the temperature error in the lower‐level troposphere in short‐range numerical weather prediction (NWP). The Global Ensemble Forecast System version 12 (GEFSv12) reforecast exhibited large‐temperature errors in high‐loading areas (North India, Africa, South America, and China). In 1‐day GEFSv12 forecasts, the largest average temperature error occurred in the aerosol optical depth (AOD) peak month, and the daily error distribution corresponded to the daily AOD distribution. Even though the temperature error in the 1‐day operational forecasts was smaller than that in the GEFSv12 forecasts, the forecast uncertainties in the operational forecasts were comparable to those in 3‐day GEFSv12 forecasts over high‐loading areas. The daily temperature errors in all NWP models exhibited a correlation coefficient of ∼0.5–0.6 for the AOD over Central Africa and northern South America and ∼0.3–0.6 for AOD anomalies over China and northern South America. These results indicated that the interannual aerosol variability contributed 25–36% to errors, and the daily variability contributed 10%–36% to temperature errors in 3‐day forecasts. Although the correlation was low, aerosol impacts also emerged in North India and Central Africa. Partial correlation and composite analysis suggested that the direct effect mainly influenced temperature forecast errors over northern South America, whereas both direct and indirect effects influenced temperature errors over China. Model intercomparison revealed that operational NWP models could experience common forecast errors associated with aerosols in high‐loading areas.
Sensitivities of Cross‐Tropopause Transport in Midlatitude Overshooting Convection to the Lower Stratosphere Environment
Authors: Gordon Andrea E. , Homeyer Cameron R.
Published: June 2022

Tropopause‐overshooting convection in the midlatitudes rapidly transports lower troposphere air and cloud material to the upper troposphere and lower stratosphere (UTLS), with notable events resulting in the formation of above‐anvil cirrus plumes (AACPs). However, there is limited understanding of how transport driven by overshooting convection and AACP properties are modified by variations in UTLS environments, especially the extent of stratosphere‐to‐troposphere (i.e., downward) transport. Here, AACP development and UTLS transport sensitivities to lower stratosphere stability and the UTLS wind environment are evaluated. The Bryan Cloud Model is used to simulate midlatitude supercell convection and evaluate resulting UTLS composition changes within two common midlatitude thermodynamic environments: a single tropopause and a double tropopause, and two UTLS wind environments: one with a stronger stratospheric wind profile supportive of frequent gravity wave breaking and AACP development and the other with a weaker stratospheric wind profile to suppress gravity wave breaking and discourage AACP formation. Multiple passive tracers and water vapor concentrations are used to evaluate the exchange of air between the troposphere and stratosphere and transport confined to each layer. It is found that greater troposphere‐to‐stratosphere transport (TST) and stratospheric hydration occurs in storms with AACPs, while stratosphere‐to‐troposphere transport (STT) is greater in storms without AACPs. This STT is facilitated by a mechanical oscillation induced by the overshoot. AACP‐producing storms have increased downward transport of stratospheric overworld air to the lowermost stratosphere, which is enhanced within a double tropopause environment. More expansive AACPs, deeper overshoots, and greater TST also occurs in double tropopause environments.
A Dynamic Pore Network Model for Imbibition Simulation Considering Corner Film Flow
Authors: Zhao Jianlin , Qin Feifei , Kang Qinjun , Qin Chaozhong , Derome Dominique , Carmeliet Jan
Published: June 2022

Wetting films can develop in the corners of angular pores under strong wetting conditions. Modeling the dynamics of corner film remains elusive using direct numerical simulations because of the significant scale difference between main meniscus and corner film flow. In this paper, the modified interacting capillary bundle model (ICB), developed in our previous work to describe accurately corner film dynamics in a single square tube, is incorporated into a single‐pressure dynamic pore network model (DPNM) to simulate imbibition in strongly wetting porous media with corner film flow. The traditional pore network is decomposed into several layers of interacting subpore networks where the 0th layer of subpore network simulates the main meniscus flow and higher layers the corner film flow. The fluid flow between different layers is captured by interlayer throats. In addition, the snap‐off mechanism caused by the thickening of wetting corner film is considered. The accuracy of the developed model is validated for four cases: spontaneous imbibition in a single square tube, wetting fluid redistribution through corner films under a capillary pressure difference, snap off in a narrow throat connecting two large pores, and imbibition dynamics in a real microfluidic porous geometry. The validated model is then used to simulate both spontaneous and controlled imbibition in a pore network with random pore size distribution. The interaction between corner film and main meniscus flow in porous media is analyzed from a pore‐scale perspective.
Acid sphingomyelinase/ceramide system in schizophrenia: implications for therapeutic intervention as a potential novel target
Authors: Zhuo Chuanjun , Zhao Feifei , Tian Hongjun , Chen Jiayue , Li Qianchen , Yang Lei , Ping Jing , Li Ranli , Wang Lina , Xu Yong , Cai Ziyao , Song Xueqin
Published: June 2022

Schizophrenia is a severe mental illness, as the efficacies of current antipsychotic medications are far from satisfactory. An improved understanding of the signaling molecules involved in schizophrenia may provide novel therapeutic targets. Acid sphingomyelinase (ASM) catalyzes cellular membrane sphingomyelin into ceramide, which is further metabolized into sphingosine-1-phophate (S1P). ASM, ceramide, and S1P at the cell surface exert critical roles in the regulation of biophysical processes that include proliferation, apoptosis, and inflammation, and are thereby considered important signaling molecules. Although research on the ASM/ceramide system is still in its infancy, structural and metabolic abnormalities have been demonstrated in schizophrenia. ASM/ceramide system dysfunction is linked to the two important models of schizophrenia, the dopamine (DA) hypothesis through affecting presynaptic DA signaling, and the vulnerability-stress-inflammation model that includes the contribution of stress on the basis of genetic predisposition. In this review, we highlight the current knowledge of ASM/ceramide system dysfunction in schizophrenia gained from human and animal studies, and formulate future directions from the biological landscape for the development of new treatments. Collectively, these discoveries suggest that aberrations in the ASM/ceramide system, especially in ASM activity and levels of ceramide and S1P, may alter cerebral microdomain structure and neuronal metabolism, leading to neurotransmitter (e.g., DA) dysfunction and neuroinflammation. As such, the ASM/ceramide system may offer therapeutic targets for novel medical interventions. Normalization of the aberrant ASM/ceramide system or ceramide reduction by using approved functional inhibitors of ASM, such as fluvoxamine and rosuvastatin, may improve clinical outcomes of patients with schizophrenia. These transformative findings of the ASM/ceramide system in schizophrenia, although intriguing and exciting, may pose scientific questions and challenges that will require further studies for their resolution.
Bateman gradients from first principles
Authors: Lehtonen Jussi
Published: June 2022

In 1948, Angus Bateman presented experiments and concepts that remain influential and debated in sexual selection. The Bateman gradient relates reproductive success to mate number, and Bateman presented this as the cause of intra-masculine selection. A deeper causal level was subsequently asserted: that the ultimate cause of sex differences in Bateman gradients is the sex difference in gamete numbers, an argument that remains controversial and without mathematical backup. Here I develop models showing how asymmetry in gamete numbers alone can generate steeper Bateman gradients in males. This conclusion remains when the further asymmetry of internal fertilisation is added to the model and fertilisation is efficient. Strong gamete limitation can push Bateman gradients towards equality under external fertilisation and reverse them under internal fertilisation. Thus, this study provides a mathematical formalisation of Bateman’s brief verbal claim, while demonstrating that the link between gamete number and Bateman gradients is not inevitable nor trivial.
Neutralization of Omicron BA.1, BA.2, and BA.3 SARS-CoV-2 by 3 doses of BNT162b2 vaccine
Authors: Kurhade Chaitanya , Zou Jing , Xia Hongjie , Cai Hui , Yang Qi , Cutler Mark , Cooper David , Muik Alexander , Jansen Kathrin U. , Xie Xuping , Swanson Kena A. , Shi Pei‑Yong
Published: June 2022

The newly emerged Omicron SARS-CoV-2 has several distinct sublineages including BA.1, BA.2, and BA.3. BA.1 accounts for the initial surge and is being replaced by BA.2, whereas BA.3 is at a low prevalence at this time. Here we report the neutralization of BNT162b2-vaccinated sera (collected 1 month after dose 3) against the three Omicron sublineages. To facilitate the neutralization testing, we have engineered the complete BA.1, BA.2, or BA.3 spike into an mNeonGreen USA-WA1/2020 SRAS-CoV-2. All BNT162b2-vaccinated sera neutralize USA-WA1/2020, BA.1-, BA.2-, and BA.3-spike SARS-CoV-2s with titers of >20; the neutralization geometric mean titers (GMTs) against the four viruses are 1211, 336, 300, and 190, respectively. Thus, the BA.1-, BA.2-, and BA.3-spike SARS-CoV-2s are 3.6-, 4.0-, and 6.4-fold less efficiently neutralized than the USA-WA1/2020, respectively. Our data have implications in vaccine strategy and understanding the biology of Omicron sublineages.
Mnemonic construction and representation of temporal structure in the hippocampal formation
Authors: Bellmund Jacob L. S. , Deuker Lorena , Montijn Nicole D. , Doeller Christian F.
Published: June 2022

The hippocampal-entorhinal region supports memory for episodic details, such as temporal relations of sequential events, and mnemonic constructions combining experiences for inferential reasoning. However, it is unclear whether hippocampal event memories reflect temporal relations derived from mnemonic constructions, event order, or elapsing time, and whether these sequence representations generalize temporal relations across similar sequences. Here, participants mnemonically constructed times of events from multiple sequences using infrequent cues and their experience of passing time. After learning, event representations in the anterior hippocampus reflected temporal relations based on constructed times. Temporal relations were generalized across sequences, revealing distinct representational formats for events from the same or different sequences. Structural knowledge about time patterns, abstracted from different sequences, biased the construction of specific event times. These findings demonstrate that mnemonic construction and the generalization of relational knowledge combine in the hippocampus, consistent with the simulation of scenarios from episodic details and structural knowledge.
Anderson transition in stoichiometric Fe2VAl: high thermoelectric performance from impurity bands
Authors: Garmroudi Fabian , Parzer Michael , Riss Alexander , Ruban Andrei V. , Khmelevskyi Sergii , Reticcioli Michele , Knopf Matthias , Michor Herwig , Pustogow Andrej , Mori Takao , Bauer Ernst
Published: June 2022

Discovered more than 200 years ago in 1821, thermoelectricity is nowadays of global interest as it enables direct interconversion of thermal and electrical energy via the Seebeck/Peltier effect. In their seminal work, Mahan and Sofo mathematically derived the conditions for ’the best thermoelectric’—a delta-distribution-shaped electronic transport function, where charge carriers contribute to transport only in an infinitely narrow energy interval. So far, however, only approximations to this concept were expected to exist in nature. Here, we propose the Anderson transition in a narrow impurity band as a physical realisation of this seemingly unrealisable scenario. An innovative approach of continuous disorder tuning allows us to drive the Anderson transition within a single sample: variable amounts of antisite defects are introduced in a controlled fashion by thermal quenching from high temperatures. Consequently, we obtain a significant enhancement and dramatic change of the thermoelectric properties from p-type to n-type in stoichiometric Fe2VAl, which we assign to a narrow region of delocalised electrons in the energy spectrum near the Fermi energy. Based on our electronic transport and magnetisation experiments, supported by Monte-Carlo and density functional theory calculations, we present a novel strategy to enhance the performance of thermoelectric materials.
A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge
Authors: Zhou Biao , Zhou Runhong , Tang Bingjie , Chan Jasper Fuk-Woo , Luo Mengxiao , Peng Qiaoli , Yuan Shuofeng , Liu Hang , Mok Bobo Wing-Yee , Chen Bohao , Wang Pui , Poon Vincent Kwok-Man , Chu Hin , Chan Chris Chung-Sing , Tsang Jessica Oi-Ling , Chan Chris Chun-Yiu , Au Ka-Kit , Man Hiu-On , Lu Lu , To Kelvin Kai-Wang , Chen Honglin , Yuen Kwok-Yung , Dang Shangyu , Chen Zhiwei
Published: June 2022

The strikingly high transmissibility and antibody evasion of SARS-CoV-2 Omicron variants have posed great challenges to the efficacy of current vaccines and antibody immunotherapy. Here, we screen 34 BNT162b2-vaccinees and isolate a public broadly neutralizing antibody ZCB11 derived from the IGHV1-58 family. ZCB11 targets viral receptor-binding domain specifically and neutralizes all SARS-CoV-2 variants of concern, especially with great potency against authentic Omicron and Delta variants. Pseudovirus-based mapping of 57 naturally occurred spike mutations or deletions reveals that S371L results in 11-fold neutralization resistance, but it is rescued by compensating mutations in Omicron variants. Cryo-EM analysis demonstrates that ZCB11 heavy chain predominantly interacts with Omicron spike trimer with receptor-binding domain in up conformation blocking ACE2 binding. In addition, prophylactic or therapeutic ZCB11 administration protects lung infection against Omicron viral challenge in golden Syrian hamsters. These results suggest that vaccine-induced ZCB11 is a promising broadly neutralizing antibody for biomedical interventions against pandemic SARS-CoV-2.
hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells
Authors: Feng Shenglei , Li Jinmei , Wen Hui , Liu Kuan , Gui Yiqian , Wen Yujiao , Wang Xiaoli , Yuan Shuiqiao
Published: June 2022

Coordinated regulation of alternative pre-mRNA splicing is essential for germ cell development. However, the underlying molecular mechanism that controls alternative mRNA expression during germ cell development remains elusive. Herein, we show that hnRNPH1 is highly expressed in the reproductive system and recruits the PTBP2 and SRSF3 to modulate the alternative splicing in germ cells. Conditional knockoutHnrnph1in spermatogenic cells causes many abnormal splicing events, thus affecting the genes related to meiosis and communication between germ cells and Sertoli cells. This is characterized by asynapsis of chromosomes and impairment of germ-Sertoli communications, which ultimately leads to male sterility. Markedly,Hnrnph1germline-specific mutant female mice are also infertile, andHnrnph1-deficient oocytes exhibit a similar defective synapsis and cell-cell junction as seen inHnrnph1-deficient male germ cells. Collectively, our data support a molecular model wherein hnRNPH1 governs a network of alternative splicing events in germ cells via recruitment of PTBP2 and SRSF3.
Dietary supplementation with biogenic selenium nanoparticles alleviate oxidative stress-induced intestinal barrier dysfunction
Authors: Qiao Lei , Zhang Xinyi , Pi Shanyao , Chang Jiajing , Dou Xina , Yan Shuqi , Song Xiaofan , Chen Yue , Zeng Xiaonan , Zhu Lixu , Xu Chunlan
Published: June 2022

Selenium (Se) is an essential micronutrient that promotes body health. Endemic Se deficiency is a major nutritional challenge worldwide. The low toxicity, high bioavailability, and unique properties of biogenic Se nanoparticles (SeNPs) allow them to be used as a therapeutic drug and Se nutritional supplement. This study was conducted to investigate the regulatory effects of dietary SeNPs supplementation on the oxidative stress-induced intestinal barrier dysfunction and its association with mitochondrial function and gut microbiota in mice. The effects of dietary SeNPs on intestinal barrier function and antioxidant capacity and its correlation with gut microbiota were further evaluated by a fecal microbiota transplantation experiment. The results showed that Se deficiency caused a redox imbalance, increased the levels of pro-inflammatory cytokines, altered the composition of the gut microbiota, and impaired mitochondrial structure and function, and intestinal barrier injury. Exogenous supplementation with biogenic SeNPs effectively alleviated diquat-induced intestinal barrier dysfunction by enhancing the antioxidant capacity, inhibiting the overproduction of reactive oxygen species (ROS), preventing the impairment of mitochondrial structure and function, regulating the immune response, maintaining intestinal microbiota homeostasis by regulating nuclear factor (erythroid-derived-2)-like 2 (Nrf2)-mediated NLR family pyrin domain containing 3 (NLRP3) signaling pathway. In addition, Se deficiency resulted in a gut microbiota phenotype that is more susceptible to diquat-induced intestinal barrier dysfunction. Supranutritional SeNPs intake can optimize the gut microbiota to protect against intestinal dysfunctions. This study demonstrates that dietary supplementation of SeNPs can prevent oxidative stress-induced intestinal barrier dysfunction through its regulation of mitochondria and gut microbiota.
Individual differences in frontoparietal plasticity in humans
Authors: Boroshok Austin L. , Park Anne T. , Fotiadis Panagiotis , Velasquez Gerardo H. , Tooley Ursula A. , Simon Katrina R. , Forde Jasmine C. P. , Delgado Reyes Lourdes M. , Tisdall M. Dylan , Bassett Dani S. , Cooper Emily A. , Mackey Allyson P.
Published: June 2022

Neuroplasticity, defined as the brain’s potential to change in response to its environment, has been extensively studied at the cellular and molecular levels. Work in animal models suggests that stimulation to the ventral tegmental area (VTA) enhances plasticity, and that myelination constrains plasticity. Little is known, however, about whether proxy measures of these properties in the human brain are associated with learning. Here, we investigated the plasticity of the frontoparietal system by asking whether VTA resting-state functional connectivity and myelin map values (T1w/T2w ratios) predicted learning after short-term training on the adaptive n-back (n = 46, ages 18–25). We found that stronger baseline connectivity between VTA and lateral prefrontal cortex predicted greater improvements in accuracy. Lower myelin map values predicted improvements in response times, but not accuracy. Our findings suggest that proxy markers of neural plasticity can predict learning in humans.
Chimeric adenoviral (Ad5.F35) and listeria vector prime-boost immunization is safe and effective for cancer immunotherapy
Authors: Flickinger John C. , Staudt Ross E. , Singh Jagmohan , Carlson Robert D. , Barton Joshua R. , Baybutt Trevor R. , Rappaport Jeffrey A. , Zalewski Alicja , Pattison Amanda , Waldman Scott A. , Snook Adam E.
Published: June 2022

Strategies to augment immunity to self/neoantigens expressed by cancers are urgently needed to expand the proportion of patients benefiting from immunotherapy, particularly for GI cancers where only a fraction of patients respond to immunotherapies. However, current vaccine strategies are limited by poor immunogenicity, pre-existing vector-specific immunity, and vaccine-induced vector-specific immunity. Here, we examined a prime-boost strategy using a chimeric adenoviral vector (Ad5.F35) that resists pre-existing immunity followed by recombinant Listeria monocytogenes (Lm) to amplify immunity to the GI cancer antigen GUCY2C. This previously unexplored combination enhanced the quantity, avidity, polyfunctionality, and antitumor efficacy of GUCY2C-specific effector CD8+ T cells, without toxicity in any tissue, including GUCY2C-expressing intestines and brain. Importantly, this combination was partially resistant to pre-existing immunity to Ad5 which is endemic in human populations and vector-specific immunity did not limit the ability of multiple Lm administrations to repeatedly enhance GUCY2C-specific responses. Broadly, these findings suggest that cancer patient immunizations targeting self/neoantigens, as well as immunizations for difficult infectious diseases (HIV, malaria, etc), may be most successful using a combination of Ad5.F35-based priming, followed by Lm-based boosting. More specifically, Lm-GUCY2C may be utilized to amplify GUCY2C-specific immunity in patients receiving adenovirus-based GUCY2C vaccines currently in clinical trials to prevent or treat recurrent GI cancer.
Engineering the hydroxyl content on aluminum oxyhydroxide nanorod for elucidating the antigen adsorption behavior
Authors: Yu Ge , Liang Zhihui , Yu Zilan , Li Min , Yang Wenqi , Zhang Yawei , Zhao Yuhang , Yang Cheng , Xue Changying , Shi Li , Sun Bingbing
Published: June 2022

The interaction between the aluminum salt-based adjuvants and the antigen in the vaccine formulation is one of the determining factors affecting the immuno-potentiation effect of vaccines. However, it is not clear how the intrinsic properties of the adjuvants could affect this interaction, which limits to benefit the improvement of existing adjuvants and further formulation of new vaccines. Here, we engineered aluminum oxyhydroxide (AlOOH) nanorods and used a variety of antigens including hepatitis B surface antigen (HBsAg), SARS-CoV-2 spike protein receptor-binding domain (RBD), bovine serum albumin (BSA) and ovalbumin (OVA) to identify the key physicochemical properties of adjuvant that determine the antigen adsorption at the nano-bio interface between selected antigen and AlOOH nanorod adjuvant. By using various physicochemical and biophysical characterization methods, it was demonstrated that the surface hydroxyl contents of AlOOH nanorods affected the adsorptive strength of the antigen and their specific surface area determined the adsorptive capacity of the antigen. In addition, surface hydroxyl contents had an impact on the stability of the adsorbed antigen. By engineering the key intrinsic characteristics of aluminum-based adjuvants, the antigen adsorption behavior with the aluminum adjuvant could be regulated. This will facilitate the design of vaccine formulations to optimize the adsorption and stability of the antigen in vaccine.
Combining interventions to reduce the spread of viral misinformation
Authors: Bak-Coleman Joseph B. , Kennedy Ian , Wack Morgan , Beers Andrew , Schafer Joseph S. , Spiro Emma S. , Starbird Kate , West Jevin D.
Published: June 2022

Misinformation online poses a range of threats, from subverting democratic processes to undermining public health measures. Proposed solutions range from encouraging more selective sharing by individuals to removing false content and accounts that create or promote it. Here we provide a framework to evaluate interventions aimed at reducing viral misinformation online both in isolation and when used in combination. We begin by deriving a generative model of viral misinformation spread, inspired by research on infectious disease. By applying this model to a large corpus (10.5 million tweets) of misinformation events that occurred during the 2020 US election, we reveal that commonly proposed interventions are unlikely to be effective in isolation. However, our framework demonstrates that a combined approach can achieve a substantial reduction in the prevalence of misinformation. Our results highlight a practical path forward as misinformation online continues to threaten vaccination efforts, equity and democratic processes around the globe.
Effects of a healthy lifestyle intervention and COVID-19-adjusted training curriculum on firefighter recruits
Authors: Lan Fan-Yun , Scheibler Christopher , Hershey Maria Soledad , Romero-Cabrera Juan Luis , Gaviola Gabriel C. , Yiannakou Ioanna , Fernandez-Montero Alejandro , Christophi Costas A. , Christiani David C. , Sotos-Prieto Mercedes , Kales Stefanos N.
Published: June 2022

There are knowledge gaps regarding healthy lifestyle (HLS) interventions in fire academy settings and also concerning the impacts of the pandemic on training. We enrolled fire recruits from two fire academies (A and B) in New England in early 2019 as the historical control group, and recruits from academies in New England (B) and Florida (C), respectively, during the pandemic as the intervention group. The three academies have similar training environments and curricula. The exposures of interest were a combination of (1) an HLS intervention and (2) impacts of the pandemic on training curricula and environs (i.e. social distancing, masking, reduced class size, etc.). We examined the health/fitness changes throughout training. The follow-up rate was 78%, leaving 92 recruits in the historical control group and 55 in the intervention group. The results show an HLS intervention improved the effects of fire academy training on recruits healthy behaviors (MEDI-lifestyle score, 0.5 ± 1.4 vs. − 0.3 ± 1.7), systolic blood pressure (− 7.2 ± 10.0 vs. 2.9 ± 12.9 mmHg), and mental health (Beck Depression score, − 0.45 ± 1.14 vs. − 0.01 ± 1.05) (all P < 0.05). The associations remained significant after multivariable adjustments. Moreover, a 1-point MEDI-lifestyle increment during academy training is associated with about 2% decrement in blood pressures over time, after multivariable adjustments (P < 0.05). Nonetheless, the impacts of pandemic restrictions on academy procedures compromised physical fitness training, namely in percent body fat, push-ups, and pull-ups.
A hybrid biological neural network model for solving problems in cognitive planning
Authors: Powell Henry , Winkel Mathias , Hopp Alexander V. , Linde Helmut
Published: June 2022

A variety of behaviors, like spatial navigation or bodily motion, can be formulated as graph traversal problems through cognitive maps. We present a neural network model which can solve such tasks and is compatible with a broad range of empirical findings about the mammalian neocortex and hippocampus. The neurons and synaptic connections in the model represent structures that can result from self-organization into a cognitive map via Hebbian learning, i.e. into a graph in which each neuron represents a point of some abstract task-relevant manifold and the recurrent connections encode a distance metric on the manifold. Graph traversal problems are solved by wave-like activation patterns which travel through the recurrent network and guide a localized peak of activity onto a path from some starting position to a target state.
Disparities in outcomes among patients diagnosed with cancer in proximity to an emergency department visit
Authors: Pettit Nicholas , Sarmiento Elisa , Kline Jeffrey
Published: June 2022

A suspected diagnosis of cancer in the emergency department (ED) may be associated with poor outcomes, related to health disparities, however data are limited. This is a retrospective observational cohort of the Indiana State Department of Health Cancer Registry, and the Indiana Network for Patient Care. First time cancer diagnoses appearing in the registry between January 2013 and December 2017 were included. Cases identified as patients who had an ED visit in the 6 months before their cancer diagnosis; controls had no preceding ED visits. The primary outcome was mortality, comparing ED-associated mortality to non-ED-associated. 134,761 first-time cancer patients were identified, including 15,432 (11.5%) cases. The mean age was same at 65, more of the cases were Black than the controls (12.4% vs 7.4%, P < .0001) and more were low income (36.4%. vs 29.3%). The top 3 ED-associated cancer diagnoses were lung (18.4%), breast (8.9%), and colorectal cancers (8.9%), whereas the controls were breast (17%), lung (14.9%), and prostate cancers (10.1%). Cases observed an over three-fold higher mortality, with cumulative death rate of 32.9% for cases vs 9.0% for controls (P < .0001). Regression analysis predicting mortality, controlling for many confounders produced an odds ratio of 4.12 (95% CI 3.72–4.56 for cases). This study found that an ED visit within 6 months prior to the first time of ICD-coded cancer is associated with Black race, low income and an overall three-fold increased adjusted risk of death. The mortality rates for ED-associated cancers are uniformly worse for all cancer types. These data suggest that additional work is needed to reduce disparities among ED-associated cancer diagnoses.
Palaeoproteomics guidelines to identify proteinaceous binders in artworks following the study of a 15th-century painting by Sandro Botticelli’s workshop
Authors: Di Gianvincenzo F. , Peggie D. , Mackie M. , Granzotto C. , Higgitt C. , Cappellini E.
Published: June 2022

Undertaking the conservation of artworks informed by the results of molecular analyses has gained growing importance over the last decades, and today it can take advantage of state-of-the-art analytical techniques, such as mass spectrometry-based proteomics. Protein-based binders are among the most common organic materials used in artworks, having been used in their production for centuries. However, the applications of proteomics to these materials are still limited. In this work, a palaeoproteomic workflow was successfully tested on paint reconstructions, and subsequently applied to micro-samples from a 15th-century panel painting, attributed to the workshop of Sandro Botticelli. This method allowed the confident identification of the protein-based binders and their biological origin, as well as the discrimination of the binder used in the ground and paint layers of the painting. These results show that the approach is accurate, highly sensitive, and broadly applicable in the cultural heritage field, due to the limited amount of starting material required. Accordingly, a set of guidelines are suggested, covering the main steps of the data analysis and interpretation of protein sequencing results, optimised for artworks.
Secretion of the siderophore rhizoferrin is regulated by the cAMP-PKA pathway and is involved in the virulence of Mucor lusitanicus
Authors: Alejandre-Castañeda Viridiana , Patiño-Medina J. Alberto , Valle-Maldonado Marco I. , Nuñez-Anita Rosa E. , Santoyo Gustavo , Castro-Cerritos Karla V. , Ortiz-Alvarado Rafael , Corrales-Escobosa Alma R. , Ramírez-Díaz Martha I. , Gutiérrez-Corona J. Felix , López-Torres Adolfo , Garre Victoriano , Meza-Carmen Víctor
Published: June 2022

Mucormycosis is a fungal infection caused by Mucorales, with a high mortality rate. However, only a few virulence factors have been described in these organisms. This study showed that deletion of rfs, which encodes the enzyme for the biosynthesis of rhizoferrin, a siderophore, in Mucor lusitanicus, led to a lower virulence in diabetic mice and nematodes. Upregulation of rfs correlated with the increased toxicity of the cell-free supernatants of the culture broth (SS) obtained under growing conditions that favor oxidative metabolism, such as low glucose levels or the presence of H2O2 in the culture, suggesting that oxidative metabolism enhances virulence through rhizoferrin production. Meanwhile, growing M. lusitanicus in the presence of potassium cyanide, N-acetylcysteine, a higher concentration of glucose, or exogenous cAMP, or the deletion of the gene encoding the regulatory subunit of PKA (pkaR1), correlated with a decrease in the toxicity of SS, downregulation of rfs, and reduction in rhizoferrin production. These observations indicate the involvement of the cAMP-PKA pathway in the regulation of rhizoferrin production and virulence in M. lusitanicus. Moreover, rfs upregulation was observed upon macrophage interaction or during infection with spores in mice, suggesting a pivotal role of rfs in M. lusitanicus infection.
New multi-criteria decision-making technique based on neutrosophic axiomatic design
Authors: Abdel-Basset Mohamed , Mohamed Mai , Mostafa Nehal N. , El-Henawy Ibrahim M. , Abouhawwash Mohamed
Published: June 2022

There are several multicriteria decision-making (MCDM) approaches presented in the literature with their characteristics. Although traditional MCDM approaches are considered a proper implementation to select the best alternative from available types, they failed to consider uncertainty which is quite high and desires to be thoughtfully measured in the selection process. This research focuses on extending MCDM in the neutrosophic environment using axiomatic design (AD) as a novel contribution to selecting appropriate Computed Tomography (CT) devices. We present a new linguistic scale for evaluating criteria and alternatives based on single-valued triangular neutrosophic numbers (SVTrN). The proposed approach is superior to other existing approaches due to its simplicity and ability to simulate natural human thinking via considering truth, indeterminacy, and falsity degrees. Then, applying it will increase the value of imaging for medical decision-making and decrease needless costs. So, this study can be valuable to researchers by helping them consider the appropriate medical imaging system selection problem theoretically under uncertainty, and for governments and organizations to design better satisfying medical imaging evaluation systems.
Ampere–Oersted field splitting of the nonlinear spin-torque vortex oscillator dynamics
Authors: Abreu Araujo Flavio , Chopin Chloé , de Wergifosse Simon
Published: June 2022

We investigate the impact of the DC current-induced Ampère–Oersted field on the dynamics of a vortex based spin-torque nano-oscillator. In this study we compare micromagnetic simulations performed using mumax$$^3$$

3

and our analytical model based on the Thiele equation approach. The latter is improved by adding two important corrections to the Thiele equation approach. The first is related to the magneto-static contribution and depends on the aspect ratio of the magnetic dot. The second is a full analytical description of the Ampère–Oersted field contribution. The model describes quantitatively the simulation results in the resonant regime as well as the impact of the Ampère–Oersted field. Depending on the relative orientation between the vortex in-plane curling magnetisation (chirality) and the Ampère–Oersted field a strong splitting phenomenon appears in the fundamental properties (frequency and vortex core position) of the nano-oscillator. Thus, we show that the Ampère–Oersted field should not be neglected as it has a high impact on the spin-torque vortex oscillator dynamics.
Spatio-temporal evolution characteristics analysis and optimization prediction of urban green infrastructure: a case study of Beijing, China
Authors: Ma Yin , Zheng Xinqi , Liu Menglan , Liu Dongya , Ai Gang , Chen Xueye
Published: June 2022

The reasonable layout of green infrastructure is conducive to the low-carbon, livable and high-quality sustainable development of cities. The framework of spatio-temporal evolution characteristics and prediction analysis of Urban Green Infrastructure (UGI) was constructed by integrating morphological spatial pattern analysis (MSPA) and CA-Markov in the study. We analyzed the spatio-temporal evolution characteristics of UGI in Beijing from 1990 to 2019, predicted its future change trend in 2030, and put forward the optimization scheme for the ecological network of UGI. The area change of UGI presented a "V" shape from 1990 to 2019 in Beijing, and the turning point was around 2009. Its spatial distribution revealed a significant heterogeneity. The comprehensive change rate index showed a "rising and then falling" trend from 1990 to 2019. Core with an area of over 1000 km2 had inclined "C" shape, connecting the north, west and south of the study area. Among the three prediction scenarios for 2030, the area of UGI under the ecological conservation priority scenario is the largest, accounting for 86.35% of the total area. The area of UGI under the economic development priority scenario is the smallest, accounting for 76.85%. The optimization of zoning and road network are effective measures to improve the connectivity of UGI in Beijing. This study is beneficial to extend the research ideas of UGI and promote sustainable urban development.
Residential green space and air pollution are associated with brain activation in a social-stress paradigm
Authors: Dimitrov-Discher Annika , Wenzel Julia , Kabisch Nadja , Hemmerling Jan , Bunz Maxie , Schöndorf Jonas , Walter Henrik , Veer Ilya M. , Adli Mazda
Published: June 2022

We examined the influence of three major environmental variables at the place of residence as potential moderating variables for neurofunctional activation during a social-stress paradigm. Data from functional magnetic resonance imaging of 42 male participants were linked to publicly accessible governmental databases providing information on amount of green space, air pollution, and noise pollution. We hypothesized that stress-related brain activation in regions important for emotion regulation were associated positively with green space and associated negatively with air pollution and noise pollution. A higher percentage of green space was associated with stronger parietal and insular activation during stress compared with that in the control condition. More air pollution was associated with weaker activation in the same (but also extended) brain regions. These findings may serve as an important reference for future studies in the emerging field of “neuro-urbanism” and emphasize the importance of environmental factors in urban planning.
Effects of mental fatigue on risk preference and feedback processing in risk decision-making
Authors: Jia Huiqiao , Lin Chiuhsiang Joe , Wang Eric Min-yang
Published: June 2022

Mental fatigue is a common phenomenon in modern people, especially after a long period of mental work. Individuals frequently have to make critical decisions when in a mentally fatigued state. As an important and complex cognitive function, risk decision-making might be influenced by mental fatigue, which is consequent with increased distraction and poor information processing. However, how mental fatigue shapes individuals’ decision-making remains relatively unclear. The purpose of this study was to examine the effect of mental fatigue on risk decision-making performance and risk-preference in a simple gambling task, using both behavioral methods and event-related potential techniques. Forty young adults were divided into a mental fatigue group and a no-fatigue group and participated in the experiments. Results showed that individuals with mental fatigue tended to be more risk-averse than those without fatigue when facing risk options. The P300 amplitudes were smaller and FRN amplitudes were larger in the mental fatigue group than in the no-fatigue group. These findings provide insight into a relationship between mental fatigue and risk decision-making, from the perspective of the neurological mechanism.
Sex-based differences in the use of post-fire habitats by invasive cane toads (Rhinella marina)
Authors: Kaiser Shannon W. , Greenlees Matthew J. , Shine Richard
Published: June 2022

Wildfires can modify habitat attributes, and those changes may differentially affect males versus females within a species if there is pre-existing niche divergence between the sexes. We used radio-tracking and dissections to study invasive cane toads (Rhinella marina), and performed transect counts on native frogs and cane toads 12 months after extensive fires in forests of eastern Australia. Both toads and native frogs were encountered more frequently in burned sites than in unburned sites. Most microhabitat features were similar between burned versus unburned areas, but fire had differential impacts on the ecology of male versus female toads. In burned areas females were less numerous but were larger, in better body condition, and had consumed more prey (especially, coleopterans and myriapods). The impact of fire on attributes of retreat-sites (e.g., temperature, density of vegetation cover) also differed between the sexes. More generally, intraspecific divergence in ecological traits within a species (as a function of body size as well as sex) may translate into substantial divergences in the impacts of habitat change.
Impact of establishing a respiratory high dependency unit for SCAP patients on the therapeutic effect, prognosis, and expenditure: a retrospective case–control study
Authors: Yalan Qin , Jin Tong
Published: June 2022

To explore the effects of establishing a high dependency unit (HDU) on the prognosis, outcome, and expenditure of patients with severe community-acquired pneumonia (SCAP). 108 SCAP patients were recruited from the respiratory intensive care unit (RICU) of the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. Of these, 87 qualified the study-selection criteria and were divided into HDU group (treated in HDU after discharge from RICU prior to transfer to normal unit) (n = 40) and normal group (not treated in the HDU) (n = 47). In the 87 patients, 40 were divided into HDU group, which meant they transferring to HDU when got stable while another 47 were divided into normal group which meant they staying longer in RICU and transferring to normal unit when got stable. Acute Physiology and Chronic Health Evaluation II (APACHE II) and Sequential Organ Failure Assessment (SOFA) scores, duration of mechanical ventilation, hospital infection, intensive care unit syndrome, length of stay, and expenditure were compared between the two groups. The primary outcome was discharging from hospital while the secondary outcome was length of stay. There was no significant difference with respect to noninvasive ventilation time, oxygenation index, or APACHE II and SOFA scores at admission or discharge from RICU (P > 0.05). The mean invasive ventilation time (176 ± 160 h) of the HDU group was not significantly different from that in the normal group (206 ± 179 h). The period of sequential noninvasive ventilation in the HDU group (135 ± 82 h) was significantly shorter than that in the normal group (274 ± 182 h, P < 0.05). The HDU group had a shorter length of stay in hospital and RICU, and incurred lesser expenditure than patients in the normal group (P < 0.05). Patients in HDU group had almost the same therapeutic effect with shorter length of stay in hospital and RICU, and lesser expenditure.
Transient response of magnetorheological fluid on rapid change of magnetic field in shear mode
Authors: Kubík Michal , Válek Josef , Žáček Jiří , Jeniš Filip , Borin Dmitry , Strecker Zbyněk , Mazůrek Ivan
Published: June 2022

The transient behaviour of magnetorheological (MR) devices is an important parameter for modern semi-actively controlled suspension systems. A significant part of the MR device response time is the MR fluid response time itself. A significant factor is the so-called rheological response time. The rheological response time is connected with the structuring particle's time and the development of shear stress in MR fluid during the deformation. The main aim of this paper is to experimentally determine the rheological response time of MR fluid and evaluated the effect of shear rate, magnetic field level, and carrier fluid viscosity. The unique design of the rheometer, which allows the rapid change of a magnetic field, is presented. The rheological response time of MRF 132-DG and MRC-C1L is in the range of 0.8–1.4 ms, depending on the shear rate. The higher the shear rate, the shorter the response time. It can be stated that the higher the magnetization of the MR fluid, the lower the response time. The higher the viscosity, the higher the rheological response time. The measured data of rheological response time was generalized and one master curve was determined.
Heart rate markers for prediction of fetal acidosis in an experimental study on fetal sheep
Authors: Ghesquière Louise , Ternynck C. , Sharma D. , Hamoud Y. , Vanspranghels R. , Storme L. , Houfflin-Debarge V. , De Jonckheere J. , Garabedian C.
Published: June 2022

To overcome the difficulties in interpreting fetal heart rate (FHR), several tools based on the autonomic nervous system and heart rate variability (HRV) have been developed. The objective of this study was to use FHR and HRV parameters for the prediction of fetal hypoxia. It was an experimental study in the instrumented fetal sheep. Repeated umbilical cord occlusions were performed to achieve severe acidosis. Hemodynamic parameters, ECG, and blood gases were analyzed. The variables used were heart rate baseline, HRV analysis (RMSSD, SDNN, LF, HF, HFnu, Fetal Stress Index (FSI), …), and morphological analysis of decelerations. The gold standard used to classify hypoxia was the fetal arterial pH (pH < 7.10). Different multivariable statistical methods (logistic regression and decision trees) were applied for the detection of acidosis. 21 lambs were instrumented. A total of 130 pairs of FHR/fetal pH analysis were obtained of which 29 in the acidosis group and 101 in the non-acidosis group. After logistic regression model with bootstrap resampling and stepwise backward selection, only one variable was selected, FSI. The AUC of FSI alone in this model was 0.81 with a sensitivity of 0.66, specificity of 0.88, PPV of 0.61, and NPV of 0.90 considering a threshold of 68. Decision trees with CHAID and CART algorithms showed a sensitivity of 0.48 and 0.59, respectively, and a specificity of 0.94 for both. All employed methods identified HRV variables as the most predictive of acidosis. The primary variables selected automatically were those from the HRV. Supporting the use of FHRV measures for the screening of fetal acidosis during labour is interesting.
Spintronic reservoir computing without driving current or magnetic field
Authors: Taniguchi Tomohiro , Ogihara Amon , Utsumi Yasuhiro , Tsunegi Sumito
Published: June 2022

Recent studies have shown that nonlinear magnetization dynamics excited in nanostructured ferromagnets are applicable to brain-inspired computing such as physical reservoir computing. The previous works have utilized the magnetization dynamics driven by electric current and/or magnetic field. This work proposes a method to apply the magnetization dynamics driven by voltage control of magnetic anisotropy to physical reservoir computing, which will be preferable from the viewpoint of low-power consumption. The computational capabilities of benchmark tasks in single MTJ are evaluated by numerical simulation of the magnetization dynamics and found to be comparable to those of echo-state networks with more than 10 nodes.