bluuebunny/crossref_metadata_2025 huggingface dataset:
STATE EDUCATIONAL INSTITUTIONS IN THE CITIES OF THE MIDDLE VOLGA REGION AT THE END OF THE XVIII – FIRST QUARTER OF THE XIX CENTURIES
Authors:   Samara State Technical University, Biryukova A.B.
Published: February 2022

The article is devoted to the process of the formation of secular and religious schools in the cities of the Middle Volga region (Simbirsk, Saratov, and Penza provinces) from the reforms of Catherine II in the last third of the 18th century until the end of the 20s of the XIX century. The author distinguishes two main stages of reforming the state secular and religious school; on the base of archival and published sources and materials of historical research, the dates of the founding of educational institutions have been clarified. The study allows to characterize the place of the school in the socio-cultural space of the late feudal provincial city.
ROMAN POWER IN THE PERCEPTION OF THE EMPIRE’S POPULATION (I–II A.D.)
Authors:   Moscow City University, Samara Branch, Guskov E.A.
Published: February 2022

The aim of the research is the identification and analysis of socio-cultural, political and concrete historical factors that influenced the formation of the image of power in the eyes of the population of the early Roman Empire and the nature of communication between the bearers of power and society. The specifics of the perception of specific rulers and power in general by various categories of people were determined by the peculiarities of their position in the social hierarchy, the nature of the structure of the Roman state, and partly by official propaganda, which built a certain image of both the ruler himself and the entire state, as well as individual circumstances that the emperor had to face. The emperor was in different hierarchical relationships with citizens, soldiers, provincials, freedmen and slaves; the scope of his power was not the same in relation to these groups. As a result, there was no single image of power for the entire population of the Mediterranean state. It was often influenced by local traditions of power perception.
TERRITORIAL ACQUISITIONS OF THE COLONIAL ELITE OF VIRGINIA AND ARMED CONFLICTS WITH THE INDIGENOUS POPULATION OF THE OHIO VALLEY IN THE 1770S
Authors:   Samara State Technical University, Makarov E.P.
Published: February 2022

The article is devoted to the study of a number of local geopolitical consequences of the French and Indian War of 1754-1763, as a result of which the territory of the Ohio River Valley was included in projects to expand the zone of influence of the Virginian colonial elites. The study of local political and legal practices associated with the execution of royal land grants shows the peculiarities of building relationships between American colonists and the indigenous peoples of the region. The period of the early 1770s, when the economic and financial expansion of the planters provoked a number of local armed conflicts between the armed forces of Virginia and numerous Indian tribes, deserves special attention. An analysis of these issues makes it possible to better study the legal foundations of the stay of the Virginian settlers on the lands of indigenous peoples, which are often poorly studied in relation to the specifics of the historical context of each of the local conflicts.
Desain Sistem Administrasi Pengelolaan Tanah untuk Kelurahan di Kota Jakarta
Authors: Titik Lusiani  , Hafizh Moch Alief
Published: February 2022

Sistem Pengelolaan Tanah di Kelurahan Kota Jakarta saat ini dilakukan oleh staf kelurahan atau lurah secara tertulis. Proses pengelolaan tanah dan pencatatan data transaksi tanah masih menggunakan sistem pembukuan dan belum terintegerasi dengan sistem basis data. Hal tersebut dapat menghambat proses pengelolaan tanah ketika terjadi kesalahan dalam pencatatan. Proses pembuatan laporan dan penyimpanan data belum terorganisir dengan baik sehingga mengakibatkan hilangnya data-data transaksi tanah, serta belum adanya media pencarian yang digunakan untuk memberikan informasi tentang pengelolaan tanah. Berdasarkan uraian  tersebut, maka dirancan Desain Sistem Administrasi Pengelolaan Tanah  untuk Kelurahan di Kota Jakarta. Sistem yang dirancang dapat digunakan untuk mengelola data master, mengelola data tanah, melakukan transaksi tanah, melakukan pencarian pada data tanah, dan menghasilkan informasi berupa laporan history transaksi tanah. Dengan adanya  Sistem Administrasi Pengelolaan Tanah ini dapat  melakukan proses perekapan data tanah dari buku induk yang memiliki transaksi seperti jual beli, hibah, waris, wakaf, dan mutasi. Sistem pengelolaan tanah ini dapat dapat  melakukan pengelolaan tanah yang terorganisir dengan baik, sehingga sistem pelaporan menjadi lebih terstruktur.
Pengabdian KKN Mandiri Desa Raporendu Kecamatan Nangapanda Kabupaten Ende
Authors: Tyas Indah Wahyuning , Ibrahim Aldi , Meo Yohanes
Published: March 2022

Kuliah Kerja Nyata (KKN) Mandiri Universitas Flores tahun 2021 di selenggarakan pada tanggal 02 - 31 Agustus 2021. Memiliki tema yaitu, “Masyarakat Tangguh Dalam Menghadapi Covid-19 Bersama KKN Universitas Flores” dan sub tema “Pengelolaan dan Perancangan Sarana dan Prasarana Desa/Kelurahan Berbasis Lokal”. Lokasi di laksanakan di Desa Raporendu, Kecamatan Nangapanda, Kabupaten Ende, Provinsi Nusa Tenggara Timur. Kegiatan KKN ini hasil kerja sama pemerintah desa setempat, masyarakat, mahasiswa dan Dosen Pembimbing Lapangan (DPL). Tujuan kegiatan ini agar mahasiswa bisa menerapkan apa yang mereka peroleh dibangku kuliah, dan  mendapat  pengalaman  belajar  dengan ikut terlibat bersama  masyarakat  secara  langsung,  melalui masalah yang ditemukan dan mencari solusinya. Ada beberapa masalah yang dijumpai dilokasi, sehingga perlu adanya usaha bersama untuk mengurangi atau mengatasi hal tersebut. (1) minimnya fasilitas yang menunjang untuk menekan penularan virus Covid-19 di Desa Raporendu, maka dibuatkan wastafel atau tempat cuci tangan didepan Kantor Desa untuk pegawai kantor atau tamu/warga setempat yang datang berkunjung, (2) Pembuatan bak sampah dari bahan batako untuk mengatasi pencemaran lingkungan akibat sampah yang berserakan, (3) memperbaiki instalasi listrik di pelabuhan, (4) pembuatan gapura dari bahan bambu lokal, (5) kerja bakti membersihkan rumah ibadat dan lingkungan desa. Dari hasil kegiatan ini diharapkan dapat memberikan manfaat bagi pemerintah dan masyarakat setempat, dan dapat bekerja sama untuk kegiatan KKN tahun selanjutnya.

Kata Kunci: KKN Mandiri, Desa Raporendu, Wastafel, Bak Sampah, Kerja Bakti
Bandicam: Alternatif Media Pembelajaran Interaktif dan Komunikatif di Masa Pandemi Covid 19
Authors: Ginting Pirman , Hasnah Yenni , Syahputri Diani
Published: March 2022

This activity is Bandicam-based learning media workshop for teacher aims to elevate the competence of teachers in utilizing online learning media in order to create more interesting/interactive/communicative teaching and learning activities, particularly during the Covid 19 pandemic. In an effort to realize this goal, this activity is carried out in collaboration with partner schools through socialization method and workshop. Based on the results, the teachers reveal that this activity was very benefeted for them in enriching the insight and creativity of the teachers to apply more interesting and interactive learning media for online learning so that students would become more motivated and enthusiastic in participating in learning. It is indicated from the ability of teachers to produce learning videos that are quite interesting and communicative through the Bandicam application.
Prieširdžių virpėjimo įtaka plaučių embolijos eigai
Authors: Zinkienė Diana , Bartkutė Gabrielė , Banaitytė Dovilė
Published: February 2022

Tyrimo tikslas. Įvertinti prieširdžių virpėjimo (PV) įtaką plaučių embolijos (PE) eigai ir baigtims. Tyrimo metodai. Trejų metų laikotarpiu atliktas retrospektyvinis tyrimas, kurio metu analizuotos 81 paciento, hospitalizuoto dėl pirmą kartą diagnozuotos plaučių embolijos, ligos istorijos. Sudarytos keturios tiriamųjų grupės: sergantys lėtiniu prieširdžių virpėjimu ir vartojantys antikoaguliantus, sergantys lėtiniu prieširdžių virpėjimu ir nevartojantys antikoaguliantų, neturintys šio ritmo sutrikimo ir vartojantys antikoaguliantus bei nesergantys prieširdžių virpėjimu ir nevartojantys antikoaguliantų. Rezultatai. 21 (25,9 proc.) tiriamasis sirgo lėtiniu prieširdžių virpėjimu. Išanalizavus rezultatus, nebuvo rasta statistiškai reikšmingo ryšio tarp lėtinio prieširdžių virpėjimo anamnezėje ir plaučių embolijos eigos. Ligos eiga, vertinant D-dimerų koncentraciją, deguonies saturacijos rodmenis (SpO2) ir krūtinės ląstos kompiuterinės tomografijos (KT) rezultatus, visose tiriamųjų grupėse buvo panaši. 26 pacientai mirė, iš jų 12 (46,15 proc.) sirgo lėtiniu prieširdžių virpėjimu. Išvados. Sergančiųjų prieširdžių virpėjimu baigtys nebuvo blogesnės nei pacientų, kuriems nebuvo diagnozuotas prieširdžių virpėjimas.
Acute appendicitis and pediatric multi-system inflammatory syndrome overlap
Authors: Vansevičienė Idilė , Dekerytė Inga , Krunkaitytė Ugnė , Lukošiūtė-Urbonienė Aušra , Malcius Dalius , Barauskas Vidmantas
Published: February 2022

Aim. Our aim was to present acute appendicitis cases with pediatric multi-system inflammatory syndrome (MIS-C), how to spot MIS-C and how to treat it. Materials and methods. We analyzed 6 patients, admitted to the Pediatric Surgery Department at the Hospital of Lithuanian University of Health Sciences from 2021 January 7th to March 23rd with acute appendicitis, who were later confirmed to have MIS-C. Results. All were treated with antibiotics and five were operated. All patients were found to have a deteriorating condition and increase in inflammatory markers despite treatment and were found to have MIS-C, with all of them having positive Immunoglobulin G for SARS-CoV-2. Conclusion. During the COVID-19 pandemic, even with clear signs of acute appendicitis, MIS-C must be considered in children with known recent exposure to COVID-19 or in patients where surgical and antibiotic treatment does not improve the condition and other organ system involvement is noticed.
Šeimos gydytojo laboratorinės diagnostikos galimybės
Authors: Dumbliauskaitė Urtė , Staikūnienė Jolita , Jukonė Monika , Vencevičienė Lina
Published: February 2022

Įvadas. Remiantis įsigaliojusia šeimos gydytojo norma, pateikiamos lentelės, kuriose apibrėžiami tyrimai, reikalingi šeimos gydytojo kompetencijai priskiriamoms ligoms ir sveikatos sutrikimams diagnozuoti bei gydyti. Lentelėse pateikiamos tyrimų skyrimo indikacijos bei dažniai yra nurodyti remiantis šiuo metu galiojančiais LR SAM ministro įsakymais. Tikimasi, kad pateikiama informacija bus aktuali, naudinga ir palengvins šeimos gydytojo kasdienį darbą. Metodai. Literatūros apžvalga parengta remiantis mokslinių straipsnių, tarptautinių gairių, Lietuvos diagnostikos ir gydymo metodikų atranka pagal reikšminius žodžius: testings, diagnostics ir prevention. Lietuvos Respublikos įsakymų ir gydymo metodikų atranka vykdyta tinklalapyje e-seimas.lrs.lt. Išvados. Pagal pateikiamas lenteles nustatyta, kad šeimos gydytojo klinikinis darbas yra griežtai reglamentuojamas daugybės LR SAM ministro įsakymų, kurie apibrėžia laboratorinių tyrimų skyrimą pacientui. Šiuo metu galiojantys įsakymai yra nuolatos atnaujinami, todėl pateikiamos lentelės su nurodytais šaltiniais turėtų būti nuolat peržiūrimos ir papildomos.
Mikrovaskulinė angina: klinika, diagnostika ir gydymas
Authors: Kurnickaitė Žemyna , Aldujeli Ali , Alšauskė Silvija Valdonė , Unikas Ramūnas
Published: February 2022

Krūtinės angina, dar kitaip žinoma kaip krūtinės skausmas, yra geriausiai atpažįstamas miokardo išemijos simptomas. Daliai stabilia angina sergančiųjų yra atliekama diagnostinė vainikinių arterijų angiografija, o iš jų – 10–15proc. nenustatoma reikšmingų pokyčių. Moksliniuose tyrimuose plačiai aprašoma mikrovaskulinė angina, klinikinėje praktikoje įtariama pacientams, kurie skundžiasi būdingais krūtinės anginos simptomais, tačiau jiems atmesta vainikinių arterijų obstrukcija ir vazospazmas, remiantis EKG, krūvio mėginio ir diagnostinės vainikinių arterijų angiografijos tyrimais. Mikrovaskulinę funkciją galima vertinti invaziniu (CFR matavimo) ir neinvazinais (PET, SPECT, šMRT, streso echokardiografija, TTDE) metodais. Pagrindinis vainikinių mikrovaskulinių arterijų disfunkcijos mechanizmas nėra visiškai išaiškintas, tačiau rizikos veiksniais laikomi tie patys kaip ir makrovakulinę anginą sukeliantys veiksniai. Dėl sudėtingos klinikos kilmės, pagrindinis tikslas yra sumažinti krūtinės anginos simptomus MVA sergantiems pacientams. MVA gydymas apima visišką kardiovaskulinių rizikos veiksnių ir gretutinių ligų (būklių), bloginančių klinikines baigtis, kontrolę.
Šlaunies raumenų įsitempimo ir silpnumo poveikis pacientų, turinčių priekinį dubens pasvirimą, apatinės nugaros dalies skausmui
Authors: Gorelik Anton , Lendraitienė Eglė , Rimdeikienė Inesa
Published: February 2022

Šiuolaikiniame pasaulyje apatinės nugaros dalies skausmas yra vis didėjanti problema. Apatinės nugaros dalies skausmas pasireiškia tiek jauniems, tiek vyresnio amžiaus žmonėms [1, 2]. Šiuo metu apatinės nugaros dalies skausmas yra pagrindinė neįgalumo priežastis visame pasaulyje [3]. Esant nespecifiniam nugaros skausmui, dažnai pakanka tinkamai sustiprinti nusilpusius ir atpalaiduoti įsitempusius raumenis, kad skausmas sumažėtų [4]. Tyrimo tikslas. Apžvelgti mokslinėje literatūroje aprašomus metodus, kurie yra taikomi pacientams, jaučiantiems apatinės nugaros dalies skausmą dėl sėdmenų bei pilvo sienos raumenų silpnumo ir nugaros tiesiamojo bei klubinio juosmens raumens įsitempimo. Metodai. Atrinkti ir apžvelgti 42 moksliniai straipsniai anglų kalba. Išvados. Analizuotuose straipsniuose pateikiama informacija apie nugaros skausmo atsiradimą dėl nusilpusių raumenų [38]. Aktyvumo stokojantys raumenys tinkamai neatlieka savo funkcijos ir jų darbas kompensuojamas kitų raumenų pernelyg dideliu aktyvumu. Literatūroje pabrėžiama, jog dažniausiai nusilpę sėdmenų ir pilvo sienos raumenys, o įsitempę nugaros tiesiamasis ir klubinis juosmens raumuo. Įsitempusius raumenis atpalaiduoti siūloma statiniais, dinaminiais tempimo pratimais ir voluojant bei atliekant perkusinį masažą. Silpnų raumenų stiprinimas bei įsitempusių raumenų atpalaidavimas gali lemti apatinės nugaros dalies skausmo sumažėjimą.
Plaučių abscesas
Authors: Aleksienė Jomilė , Žukauskaitė Evelina , Mašanauskienė Edita
Published: February 2022

Plaučių abscesas – tai pūlingas nekrozinis plaučių audinio pažeidimas, kuriam būdingas didesnis nei 2 cm ertmės susidarymas, atsirandantis dėl mikrobinės infekcijos [1]. Gali susiformuoti pavieniai arba dauginiai dariniai. Plaučių abscesai paprastai yra polimikrobinės kilmės, dažniausiai vyrauja anaerobinės bakterijos [2]. Iki antibiotikų eros mirdavo trečdalis pacientų, sergančių plaučių abscesu, kitas trečdalis pacientų visiškai pasveikdavo, o likusieji išgyvendavo, tačiau jiems išsivystydavo tokios komplikacijos, kaip lėtinis plaučių abscesas, pleuros empiema arba bronchektazės [3]. Šiandien dauguma pacientų visiškai pasveiksta gydomi tik antibiotikais. Tačiau kartais reikalingas ir chirurginis gydymas, jei pasireiškia užsitęsęs sepsis, bronchopleurinė fistulė, absceso plyšimas pleuros ertmėje, absceso skersmuo didesnis nei 6 cm, nesėkmingai gydomas pūlinys medikamentais ilgiau nei 12 sav. arba įtariamas navikas [4]. Ligos diagnostika yra sudėtinga, todėl tai gali būti tikras iššūkis netgi patyrusiems specialistams. Šiame straipsnyje aprašomas klinikinis atvejis – 63 metų pacientui R. G. nustatytas absceduojantis pleuritas ir ūmus pielonefritas. Pacientas buvo hospitalizuotas dėl sauso, varginančio kosulio, pilvo skausmo bei karščiavimo (iki 37,8 °C).
Nutukimas vaikystėje: kada vėlu yra per vėlu?
Authors: Zinkevičiūtė Vaiva
Published: February 2022

Nutukimas bei antsvoris yra vienas didžiausią skaičių lėtinių ligų predisponuojančių veiksnių: 2 tipo cukrinį diabetą, išeminę širdies ligą, podagrą, net kai kurias vėžines ligas. Nutukimas mažina pasitenkinimą gyvenimu, yra siejamas su iš to kylančiais psichinės sveikatos sutrikimais ir didina mirtingumą. Nutukimą ir antsvorį lemia gausa veiksnių, nuo socialinių ir ekologinių iki genetinių, o dažniausiai polinkis į šią būklę yra suformuojamas vaikystėje arba dar negimus. Esminis nutukimą tiesiogiai sukeliantis veiksnys yra kalorijų perteklius, kai kalorijų suvartojama daugiau, nei sudeginama. Tai lemia įvairus obesogeninis arba nutukimą skatinantis elgesys. Vienas tokio elgesio pavyzdžių – Vakarų dieta, apimanti itin kaloringus maisto produktus, turinčius didelį kiekį cukraus, trans ir sočiųjų riebalų rūgščių, druskos ir kitų maisto priedų, taip pat – perdirbtos mėsos gaminius ir pusgaminius. Į šią grupę įeina ir fizinio aktyvumo stygius, trumpa miego trukmė ir prasta kokybė bei ilgas prie ekranų praleidžiamas laikas. Tyrimai rodo, jog vaikai, kurie prie ekranų praleidžia daugiau laiko, yra labiau linkę užkandžiauti ir suvalgyti didesnį kiekį maisto dėl nedėmesingo valgymo ir todėl sumažėjusio sotumo suvokimo, greitojo maisto reklamų, trumpėjančios miego trukmės ir prastėjančios kokybės. Šeimos gydytojai bei jų komandos nariai gali ir turi atlikti vieną pagrindinių vaidmenų šeimos švietime kurdami ir dalyvaudami ankstyvosiose intervencijose.
Obstipacija
Authors: Nutrition Institute Nestle
Published: February 2022

Kūdikiai, maitinami motinos pienu, dažniau tuštinasi, jų išmatos minkštesnės, lyginant su pieno mišiniais maitinamais kūdikiais.
Effectiveness of muscle energy technique (met) in patients with acute low back pain: Qusai experimental trial
Authors: Muhammad Usman Khalid  , Danish Hassan  , Yasir kazmi  , Muhammad Hassan  , Haroon Mansha  , Hayatullah khalid
Published: February 2022

BACKGROUND & OBJECTIVE: Low back pain is a common problem in society. Acute low back pain can persist for up to six weeks and requires immediate attention for treatment. The muscle energy technique was mostly used in rehabilitation for strengthening and relaxation purposes. The objective of the study was to find out the effectiveness of the muscle energy technique in patients with acute low back pain.

METHODOLOGY: It was a quasi-experimental trial; with a sample size of 60 were collected from 05 June 2020 to 05 November 2020. A convenient sampling technique was used and patients were divided into two groups after inclusion and exclusion criteria. The tools were the Standardized visual analog scale (VAS) and Oswestry disability index (ODI). The setting was Ibn e Siena Hospital and Research Institute, Multan and Multi-care physiotherapy clinic Multan. An Independent t-test was applied to measure the significance of data. The experimental group was treated by muscle energy technique and the control group was treated through neuromuscular control exercises.

RESULTS: Total number of patients in the study was 60, equally divided into two groups. Pre and post control and experiment group ODI mean±SD 28.13±5.25, 12.66±3.78 and 26.13±4.12, 7.80±3.14, pre and post-VAS 8.70±0.79, 8.30± 1.17 and 2.00± 1.20, 0.76± 1.00 respectively. There was a significant difference (p<0.000) between a pre and post intervention score of the Oswestry disability index (ODI) and the visual analog scale (VAS).

CONCLUSION: Muscle energy technique was more effective than neuromuscular control exercises in mechanical acute low back pain.
El derecho al proyecto de vida y la exigencia de dignidad de la persona humana
Authors: Burgos Osvaldo R.
Published: March 2022

Una lógica de acumulación y un modo de dominio que, en su avasallamiento de la conciencia y en su confiscación del tiempo futuro –dos cuestiones que Zuboff se ocupa, expresamente, de señalar- sitúan en riesgo la existencia misma de la persona; crean una máscara -un avatar, una identidad digital- que toma impunemente su lugar. Luego, compartimentando las sociedades en poblaciones o comunidades agregadas de intereses, aceleran las escalas de desigualdad y la producción de desecho –propia de toda lógica de acumulación- que, en su caso, se mide en perfiles descartables. Es decir, en personas que no interesan, que no importan. Estas dos cuestiones, la de la máscara y la del descarte, son las que van a articular nuestra exposición. Pero, repasemos ¿qué es el capitalismo de vigilancia, según Zuboff lo describe? La cuarta etapa del capitalismo, que esta vez fetichiza, para transformar en mercancía, nuestras propias conductas a futuro; dando lugar a una concentración de riqueza y de saber que alcanza niveles inauditos. ¿Cómo lo hace? A través del despliegue indiscriminado -y por tanto, anómico, no regulado- de su inteligencia artificial. Intentaré defender aquí, que, adoptando un paradigma de reparación integral –y entendiendo el derecho como libertad, como un compromiso continuo de ampliación de derechos y no como una simple herramienta de ejercicio de dominio- el derecho al proyecto de vida aparece como una noción que opera necesariamente en las dos instancias de la reparación.
Evaluation of different wetland preferences of wintering waterbird species in Çanakkale, Turkey
Authors: UYSAL İbrahim , UYSAL İbrahim
Published: February 2022

In the study, International Waterbird Census (IWC) conducted in 2021 in wetlands with different habitat characteristics around the Dardanelles were evaluated. 3086 individuals belonging to 30 waterbird species were counted in Kavak Delta, 31 species and 1150 individuals in Çardak Lagoon, 22 species and 3906 individuals in Gökçeada Salt Lake, 11 species and 289 individuals in Suvla Salt Lake and 8 species and 84 individuals in Uzunhızırlı Pond. The highest species diversity (Shannon-Wiener Indices, H: 2,473) and the highest species richness (Margalef Index, M: 4,257) were calculated in the Çardak Lagoon. As the number of habitats in the wetland increased, the number of species also increased (p<0.0001). As a result, the data obtained revealed the importance of the wetlands for the winter visitor waterbirds, and pioneering data were presented for the sustainability of the wetlands in future studies.
Die Staatsunabhängigkeit der Medien
Authors: Piolino Marina
Published: February 2022

If the journalistic media are to be able to effectively perform their essential democratic tasks of shaping public opinion and controlling state power, they must be independent of the state. At the same time, this same state must guarantee a diverse range of media and inform the public about its activities. This tension is exacerbated in the Internet age, in which expensive journalistic content production is considered less and less secure. As a result, the state's duty to safeguard media pluralism, for example by organizing a public service system or other support measures, and to carry out active public relations work is updated. This in turn increases the danger that the state will influence media activity or become a media provider itself. What limits the state has to observe in this context is elaborated in this book on the basis of a cross-media genre constitutional and international law analysis of the principle of state independence of the media.
Development and characterization of edible biofilms based on mucilage of Opuntia ficus-indica and Locust Bean Gum from Tissemsilt region in Algeria
Authors: MOUSSAOUI BADREDDINE , RAHALI ABDELLAH , GUEMOU LAID , Riazi Ali
Published: February 2022

The development of biodegradable edible films/food packaging is in the core of the new management strategies of food handling. The great challenge facing the food industry today is innovation in terms of ecological and effec-tive edible coatings, with improved mechanical and sensory qualities but at lower cost. The current study intends to develop and characterize edible films by combining crude and pure Opuntia cladode mucilage and Locust Bean Gum (LBG), then evaluate their coating effect on stored strawberry fruits. The films were formulated using the two polymers at the same con-centration (2% mucilage / 2% LBG) and glycerol as plasticizer, and they were compared for their physicochemical and mechanical properties like thick-ness, moisture content, water vapor transmission and transparency. The pH, weight loss and sensorial qualities of coated strawberries stored at 4°C were assessed during 14 days. The obtained results have shown that for the crude composite films CM-CLBG the thickness, moisture and water solubility were higher compared to those of PM-PLBG where water vapor permeability (WVP), transparency and surface contact angle (hydrophobicity) displayed the highest values. Weight loss and drop in pH of strawberries soaked in the CM-CLBG and PM-PLBG coating solutions and stored at 4°C were less signifi-cant than those of uncoated strawberries. Otherwise, coated fruits pre-served a marketable visual appearance and texture, but lost their redness and gloss after the storage period. Despite the promising potential of Opun-tia mucilage/LBG formulated films, some improvements are still needed to solve the problem of fruit appearance and meet marketing standards.
Epidemiological Characteristics of Hepatitis C Virus génotypes in East Algeria from 2011 to 2017
Authors: Zoubeida Hachemi-Aidouni  , ABLA HECINI-HANNACHI
Published: February 2022

In order to find the factors associated with the genotypes of patients with hepatitis C virus, namely, age, sex, wilaya (province) and risk factor, we adopted two statistical linear regression models. A total of 913 positive HCV patients were included in this study, coming from nine wilayas of eastern Algeria from 2011 to 2017. Genotype 1 was observed in 89.15% of cases with a predominance of subtype b (73.93%). According to the monovariate analy-sis, the wilaya of Constantine being associated with genotype 1b, the wilayas of Skikda, Jijel, Oum El Bouagui and Tebessa were more associated with ge-notype 2a. Since the blood transfusion factor is associated with genotype 1b, genotypes 1a, 2a and 2b were often associated with the surgical intervention factor. Age and sex variables had no influence. Multivariate analysis demons-trated that genotype 1 being associated with the wilaya of Constantine, the wilayas of Jijel, Oum-el-Bouaghi, Souk-Ahras and Skikda were respectively 4, 3, 2.5 and 10 times more likely to be associated with genotype 2. Genotype 1 being associated with the blood transfusion factor, surgical intervention (OR = 0.19, p-value = 1.1.10-7) has a 20 times greater chance of being associated with genotype 2. Genotype 1 has a 1.6-fold chance of being associated with patients with the age is over 55 years old. Both univariate and multivariate logistic regression analysis models provided useful information for the as-sessment of the distribution of genotypes of patients with HCV.
Phytochemical screening and biological activity of Warionia saharae Benth & Coss growing wild in Bechar, South-West Algeria
Authors: Madiha Bounegta  , Ahmed Makhloufi  , Khadidja Bouguetara  , Djamel Eddine Abdelouahid
Published: February 2022

Plants have phytotherapeutic properties such as antioxidant and antimicro-bial properties, and their rare use remains a very interesting task in medi-cine. The present work addresses the new natural substances extracted from the plant Warionia saharae, and the study of their biological, antioxidant and antifungal activities in vitro. A qualitative analysis was performed by a phyto-chemical screening of the plants. The direct contact method in solid medium carried a study of the antifungal activity of organic and aqueous extracts against four fungal strains. After, an estimation of the antioxidant power of these extracts and that of ascorbic acid by the DPPH free radical reduction method was performed. Phytochemical screening revealed the presence of reducing compounds, saponosides with a foam index of 120, tannins, alka-loids, anthocyanosides. The antifungal activity results show that the hexane extract has potent inhibitory activity against fungal strains. The MIC is 2.42 mg/ml for Penicillium sp. and 3.5 mg/ml for Fusarium sp., followed by the ethanolic extract. The antioxidant activity estimates IC50% of 6.09 μg/ml for the ethanolic extract, while the positive control, ascorbic acid, is 1.02 μg/ml. These preliminary in vitro results show that natural extracts of W. saharae Benth & Coss exhibit significant antifungal activity and antiradical power. In conclusion, this work is part of the valorization of a medicinal plant W. saha-rae grown spontaneously in the region of Bechar.
Association of TP53 P72R and MDM2 SNP309 variants with susceptibil-ity to chronic myeloid leukaemia development in Algerian population: TP53 P72R C allele is a strong risk marker and MDM2 SNP309 G allele has a protective effect
Authors: Khedidja Benseddik  , Rym Abderrahmane  , Abdellah Boudjemaa  , Aberkane Meriem  , Dorgham Samia  , Touala Chaîla Zohra  , Meroufel Djabaria Naima
Published: February 2022

Chronic myeloid leukaemia is a monoclonal myeloproliferative syndrome, whose development is related to disturbance of growth, survival, and apop-totic pathways, such as MDM2-p53 pathway, mainly due to the abnormal kinase activity of BCR-ABL. A lot of work has to be done to understand chron-ic myeloid leukaemia genetic predisposition. This is a pilot study that search-es for association between TP53 P72R variant (rs1042522); and MDM2 T309G variant (rs2279744), and the risk of chronic myeloid leukaemia occur-rence in the Algerian population. It is a case-control study using DNA sam-ples of 74 Algerian chronic myeloid leukaemia patients and 104 healthy con-trol individuals. Our results attested that TP53 P72R C allele (Pro) was strong-ly associated with increased risk of chronic myeloid leukaemia, and that TP53 P72R homozygous CC genotype should be a genetic susceptibility factor in the pathogenesis of chronic myeloid leukaemia independently of age and of gender. Furthermore, MDM2 SNP309 TT genotype was moderately associat-ed with a risk of chronic myeloid leukaemia occurrence. In conclusion, our data suggest that, in Algerian population, TP53 P72R C allele (Pro) could be a possible biomarker of chronic myeloid leukaemia susceptibility, and that MDM2 SNP309 TT genotype seems to be a low penetrance risk factor of chronic myeloid leukaemia susceptibility.
Ethnobotanical, phytochemical characterization and biological activities of Ephedra alata Decne extracts, growing wild in Bechar region, south west of Algeria
Authors: Hibi Zineb , A. Makhloufi  , R.Azzi
Published: February 2022

The increased resistance of microorganisms to antibiotics is a serious global problem that has guided research for the identification of new biomolecules with broad antibacterial activity. Ephedra alata has been the object of several researches due to its multiple uses, it known to possess antibacterial and antifungal properties. This study aimed to evaluate the ethnobotanical informations related to the use of E. alata Decne for medicinal purposes, and investigating the antimicrobial, antioxidant effects of this plant which is widely used in traditional therapy. The ethnobotanical study of E. alata Dec-ne in Bechar region is done by using a questionnaire to get an overview on various local traditional uses. Aqueous and alcoholic extracts of E. alata Dec-ne were evaluated in vitro against some bacterial and fungal strains. Broth dilution methods, disc diffusion and minimum inhibitory concentration (MIC) determination methods were used to determine the antimicrobial activity of different plant extracts. The phytochimical screening shown that E. alata Decne is rich with Flavonoids, saponins and tannins. The evaluation of anti-microbial activity showed that the aqueous under reflux extraction have the best antibacterial activity with inhibition diameters of 20 mm against Bacillus subtilis. The aqueous extracts have significant activity against tested fungal strains; the inhibition percentage was 64, 44% on Aspergillus ochrasus. For the antioxidant capacities, the ferric ion reducing antioxidant power (FRAP) and 2,2-diphenyl-1-picrylhydrazyl(DPPH) free radical scavenging activities of the extracts showed a higher antioxidant activities. The results obtained in this study show the richness of E. alata with chemical substances and may represent a new potential source of bioactive compounds in therapy.
Corona Virus and Mucormycosis: Indications and Treatment Methodology of Dark Growth in COVID-19 Patients
Authors: Neetu Kumari  , Kiran Bamel  , Prabhavathi  , Roopali Pandey  , Seema Talwar
Published: February 2022

Mucormycosis, usually called dark parasite, is an uncommon yet serious con-tagious contamination brought about by a fungal organism called mu-cormycete, which is abundant in the environment. It primarily influences individuals who have medical issues or take prescriptions that bring down the body's capacity to battle germs and ailments. It is attracting sudden attention as it is diagnosed among Covid-19 patients in certain regions of India. The sickness frequently appears in the skin and furthermore affects sinuses, lungs and brain. Individuals who are infected with COVID-19 virus have compromised immune system and are susceptible to mold contamina-tion. The individuals who were hospitalized with extreme COVID-19 sickness were recommended steroids to treat the corona infection but as a side effect gets diminished immunity that facilitates the spread of black fungus. It is a matter of great concern and the Covid management team has given a warn-ing with respect to this illness. This review is an attempt to understand the fungus as an organism, its pathogenesis, and how it is linked with the covid-19 patients.
Collateral effects of SARS-CoV-2 on active behaviors and body composition in Algerian school aged children
Authors: Benmerzoug Marwa , Brahim Djoud  , Daoudi Hadjer  , Afnane Debbache  , Amira Harbouche  , Ines Dahbia Dahmani  , Damien Vitiello  , Rouabah Leila
Published: February 2022

The SARS-CoV-2 pandemic had changed drastically the social life of children and youth, including their ability to adhere the physical activity (PA) recom-mendations. This study highlights the impact of the SARS-CoV-2 lockdown on children’s daily physical activity, sedentary behaviors and sleep duration. It also determined the impact of this specific context on adiposity and cardio-metabolic indicators among children aged from 9 to 12 years old from Con-stantine–Algeria. Children were divided into 2 groups according to the prac-tice of PA, a cross-sectional study was conducted at 2 different times. The first time, was before the SARS-CoV-2 pandemic, where the pre-lockdown lifestyle and PA data were collected via a validated questionnaire. The sec-ond time was during the lockdown, where the same questionnaire was asked to children’s parents via telephonic interviews. A significant decline in the frequencies of PA patterns by 3.8 hours has been observed in the study pop-ulation. In parallel, sedentary behaviors has been significantly increased by 4.5 hours in equal proportions between swimmers and sedentary children per day. Half of the children decreased their night sleep duration by an aver-age of 54 minutes. This new lifestyle context induced by the lockdown was associated with an increase in body weight (3.69±0.9 kg) and body mass in-dex (2.1±0.48 kg/m2) in the whole study population. These results might increase the prevalence of cardio-metabolic complications associated with overweight and obesity observed in the population of children and adoles-cents in Constantine in the near future.
Phytochemical, Biological and Pharmacological Investigation in Various Extracts from Astragalus gombo Coss & Dur L. Ex-Bunge
Authors: Leila Bellebcir  , Nacira Abidli  , Moncef Nasri  , Touhami Khorchani  , Mahmoud Mabrouk  , Nacim Zouari  , Mohamed Hajji
Published: February 2022

Astragalus gombo Coss. & Dur L. Ex-Bunge is an endemic species of Algerian arid and semi-arid regions, however, is commonly used in traditional medi-cines. The aerial part was extracted by 80/20 methanol/water and water. The first crude extract was fractionated by ethyl acetate, n-butanol and methanol. LC-ESI-MS analysis revealed 25 compounds among all fractions. The major identified phenolic acids in ethyl acetate (EAAg) fraction were the p-coumaric flowed by tans-ferulic acid (1315 and 370 μg/g extract, respec-tively). Moreover EAAg exhibited high amounts of flavonoides (cirsiliol and quercetin-3-O-galactoside by 1155 and 491 μg /g extract, respectively). EAAg fraction was the most effective antioxidant in all assays tested, followed by NBAg fraction. The EAAg exhibited higher antioxidant activity than positive control BHA. Excellent and significant linear correlations were displayed be-tween phenolic compounds and antioxidant capacities. Hence, both of frac-tions enhanced the phagocytic activity by stimulating the reticuloendothelial system at different doses 50, 70 and 100 mg/ kg compared. Results of antico-agulant activity assay revealed that AEAg, EAAg and NBAg prolonged pro-thrombin time and activated partial thromboplastin. Cytotoxicity assay of EAAg fraction against HeLa and Mcf-7 cells revealed an IC50 values 108.8±1.8 and 168.4±1.6μg/mL, respectively, after 48h of incubation. Hence,The EAAg fraction displayed significant selectivity index (SI) towards normal mouse liver cells Aml12. The results presented clearly that A. gombo have a poten-tial to be used as a natural antioxidant, especially the EAAg fraction, as an original source of bioactive molecules with anti proliferative activities and immunopromising effects.
Rutas, raíces y afectos en Desierto sonoro, de Valeria Luiselli
Authors: BERGHE KRISTINE VANDEN
Published: February 2022

Analizamos cómo se representan los personajes en la novela Desierto sonoro (2019), de Valeria Luiselli, y partimos para ello de la teoría de los afectos propuesta por Sara Ahmed en The Cultural Politics of Emotion (2004; 2014). Demostramos que la novela se apoya en una oposición entre personajes que encarnan el movimiento y las identidades fluidas, y otros que se arraigan en un lugar estable y representan formas de ser más tradicionales. Sobre los primeros el personaje materno transmite a sus hijos sentimientos de empatía mientras que inspira afectos despreciativos y miedo hacia los segundos. Desierto sonoro procura despertar estos afectos también en su lectorado. Sin embargo, al mismo tiempo suscita frustración por amalgamar distintas formas de moverse y por no brindar atención hacia aspectos socioeconómicos. Argumentamos que esta amalgamación y esta desatención se explican por el fetichismo que la novela demuestra hacia el movimiento.
En los márgenes de la nación: geografías imaginarias en Temporada de huracanes (2017) de Fernanda Melchor
Authors: LEMUS RAFAEL
Published: February 2022

Este artículo estudia la geografía imaginaria que Fernanda Melchor despliega en su novela Temporada de huracanes (2017), en particular la precaria localidad rural de La Matosa, donde ocurre la mayor parte de la obra. Ubicada en un punto impreciso del estado mexicano de Veracruz, perdida entre manglares e ingenios azucareros, La Matosa es un territorio literario que a la vez refleja y excede la nación en que se localiza, un locus ficticio que, al mismo tiempo que representa la violencia del México contemporáneo, desmiente los discursos que han querido explicar esa violencia y, aún más, el devenir histórico de México.
Desde la maqama hasta el auto sacramental: la obra temprana de José Penso de la Vega
Authors: DAVIDI EINAT
Published: February 2022

El artículo analiza dos textos en hebreo de Penso de la Vega, un ex-converso de la comunidad judía de Amsterdam: la maqama, Fábulas de animales (1668) y el auto sacramental Prisioneros de la esperanza (1673), y enfoca las tradiciones de género y sus componentes poéticos. La transición entre ambas obras refleja la madurez de la concepción barroca alegórica que aparecerá en textos posteriores y, a nivel poetológico, es una alegoría, validación y exageración del conflicto interreligioso en sus aspectos político-sociales. El paso de la reelaboración en prosa de una leyenda talmúdica a un conflicto dramático alegórico se focaliza en el mensaje moral o la abstracción del relato e internaliza la polémica interreligiosa y la identificación de las partes con fuerzas anímicas. La obra temprana de Penso ejemplifica procesos de alegorización como la transición del conflicto histórico a un drama anímico, que ofrece nuevas percepciones del surgimiento de una poética psicomáquica.
La gitana en la construcción femenina de la nación. Miradas a la alteridad étnica desde el discurso decimonónico
Authors: MARTÍN-VILLARREAL JUAN PEDRO
Published: February 2022

La imagen de la gitana se convirtió en un elemento fundamental en la recreación exótica y salvaje que desde Europa se propició del imaginario nacional español, así como también de los relatos propios que reprodujeron este discurso en la construcción pintoresca de una España sazonada de exotismos vinculada con su pasado oriental. Sin embargo, el discurso nacional que se desprende de algunos proyectos editoriales femeninos evidencia recelos a la hora de incluir a la gitana como modelo representativo de la feminidad española por considerarla un personaje marginal. Este artículo analiza las estrategias de inclusión y exclusión de la figura de la gitana en las colecciones de tipos costumbristas de la segunda mitad del siglo XIX a partir de la comparación de dos de los textos más representativos de su inclusión desde una perspectiva de género: Los españoles pintados por sí mismos (1843-1844) y Las mujeres españolas, americanas y lusitanas pintadas por sí mismas (1881-1882).
Systemic Corticosteroid Therapy for Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Vietnam: Clinical Evaluation and Analysis of Serum Cytokines
Authors: Tran Thi Huyen , Lan Pham Thi , Khang Tran Hau , Luong Vu Huy
Published: February 2022

Abstract BACKGROUND: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis are severe cutaneous adverse drug reactions. There are some immunological and genetic factors which are believed to be involved in the pathogenesis of SJS/TEN. The treatment of SJS/TEN is still controversial in which several studies showed variable results. AIMS: To evaluate clinically the efficacy of systemic corticosteroid and to analyze some related cytokines in the treatment of SJS/TEN. METHODS: This open, pilot and uncontrolled study was conducted at National Hospital of Dermatology and Venereology, in Hanoi, Vietnam, from October 2017 to September 2019. Methylprednisolone was indicated from the first day of hospitalization with the dose of 0.5-2.5 mg/kg/day (calculated according to prednisolone dose) once daily. It was continued until the patients got re-epithelialization. The efficacy of methylprednisolone was evaluated by observing clinically and analyzing related cytokines before and after the treatment. RESULTS: The mean time of re-epithelialization was 15.9 days, of hospitalization was 15.9 days (range 5-30 days). There was no in-hospital mortality in this study. The most common complication was transient glycaemia (40.6%), there was no patient with sepsis. At the day of hospitalization, serum concentrations of TNF-α, IFN-γ, IL-2, IL-5, IL-13 and IL-10 were significantly higher than those at the day of re-epithelialization (p<0.05). Serum levels of IL-4, did not have significant differences between two time points (p>0.05). CONCLUSION: The systemic corticosteroid is a good choice in the treatment of SJS/TEN. It can reduce serum levels of some cytokines that help SJS/TEN patients with avoiding mortality.
The Effect of Achievement Motivation and Self-Regulated Learning on Student Learning Behavior in the Time of Online Learning in Indonesia
Authors: Hindradjat Juliana , Hambali Imam , Atmoko Adi , Livana P. H.
Published: February 2022

BACKGROUND: Self-regulated learning (SRL) and achievement motivation are important variables in students’ learning behavior.

AIM: The purpose of this study was to examine the effect of achievement motivation and SRL on the learning behavior of junior high school students in Indonesia during the online learning period.

METHODS: The research uses a quantitative approach with a causal associative research design. The research population is junior high school students in grades VII, VIII, and IX from various regions in Indonesia during the online learning period. Research respondents total 2,880 students, who were selected through random sampling technique. Respondent data were collected using a set of questionnaires in the form of a validated achievement motivation scale, SRL, and learning behavior, and processed and analyzed using the path-analysis method.

RESULTS: The results of statistical processing show that the correlation coefficient between Achievement Motivation and SRL is 0.432 with a significant relationship and is included in the category of a fairly strong relationship. The correlation coefficient between Achievement Motivation and Learning Behavior is 0.632 with a significant relationship and is included in the category of a strong relationship. The correlation coefficient between SRL and Learning Behavior is 0.675 with a significant relationship and is included in the category of a strong relationship. Based on the Path Analysis Calculation Result Table, the path coefficient value for Achievement Motivation is 0.418 with a positive relationship direction. Simultaneous test results obtained the conclusion that there is an influence between Achievement Motivation and SRL variables on Learning Behavior of 59.8%, while the remaining 40.2% is the influence of other variables not involved in this study. The direct influence of Achievement Motivation on Learning Behavior is 17.5% and the indirect effect through SRL is 8.9%, so that if added up, the total effect is 26.4%. Then, the direct influence of SRL on Learning Behavior is 24.4% and the indirect effect through Achievement Motivation is 8.9% so that if added up, the total effect is 33.4%.

CONCLUSION: There is a significant effect between achievement motivation and SRL on student learning behavior simultaneously; there is a significant influence between achievement motivations on student learning behavior partially. There is a significant influence between SRL on Student Learning Behavior partially.
A Metformin Pharmacogenetic Study of Patients with Type 2 Diabetes Mellitus and SLC22A1 Gene Mutation
Authors: Usman Elly , Katar Yusticia
Published: February 2022

Background: The purpose of this study was to determine the profiles of patients with type 2 diabetes (T2DM) and an SLC22A1 gene mutation in order to evaluate the effect of metformin pharmacogenetics.
Methods: To assess the effect of pharmacogenetics, a mutation of the SLC22A1 gene in T2DM patients receiving metformin was investigated. Blood samples were taken from 50 diabetics of Minangkabau ethnicity who met the inclusion criteria, and SNP genotyping and blood glucose levels were determined. DNA is extracted and purified from blood samples using DNAzol® Genomic DNA Kits (Thermofischer Scientific) reagents. The Chi-square test and Independent sample T test were used to analyze the data. A statistically significant association was defined as a p-value < 0.05. Finally, the GraphPad Prism 7.00 program was used to gather and analyze data.
Results: The adjusted odds ratio for inadequate fasting blood glucose was 1.48 (95% CI 1.18-1.95) in this study, while the adjusted odds ratio for diet discipline was 1.23 (95% CI 1.18-1.95). The adjusted odds ratio for low physical activity was 1.18. (95% CI 1.05-1.81). According to the sequencing data, the proportion of mutants is high at exon 2 rs683369 (G> C), while the percentage of wildtype and heterozygous mutants is the same at introns rs4646272 (T> G).
Conclusion: Obesity, diet discipline, and low physical activity were all found to increase the likelihood of insufficient fasting blood glucose in T2DM patients. Exon 2 rs683369 (G> C) has a high proportion of mutants, but introns rs4646272 (T> G) have the same percentage of wildtype and heterozygous mutants.