bluuebunny/crossref_metadata_2025 huggingface dataset:
Isolated Amyloid-β Pathology Is Associated with Preserved Cortical Plasticity in APOE4 Alzheimer’s Disease Patients
Authors: Assogna Martina , Motta Caterina , Bonnì Sonia , Borghi Ilaria , Casula Elias Paolo , Martorana Alessandro , Koch Giacomo
Published: February 2022

Background: Long-term potentiation (LTP) like-cortical plasticity impairment and cholinergic neurotransmission deficits have been widely demonstrated in Alzheimer’s disease (AD) patients. Objective: In this study we aim to investigate the neurophysiological features underlying cognitive decline in AD patients according to the National Institute on Aging-Alzheimer’s Association (NIA-AA) classification and APOE genotype. Methods: 65 newly diagnosed AD patients were enrolled. APOE genotype and lumbar puncture for the analysis of cerebrospinal fluid biomarkers were performed for diagnostic purposes. Patients were subdivided upon NIA-AA criteria, according to the presence of biomarkers of amyloid-β (Aβ) deposition (A) and fibrillar tau (T), in four groups: A+/T–E4 (n = 9), A+/T–E3 (n = 18), A+/T+ E4 (n = 21), and A+/T+ E3 (n = 17). We applied intermittent theta burst stimulation protocol over the primary motor cortex to assess LTP-like cortical plasticity and short latency afferent inhibition (SAI) protocol to investigate central cholinergic activity. Patients were followed over 24 months. Cognitive decline was evaluated considering changes in Mini-Mental State Examination (MMSE) scores respect to the baseline. Results: A+/T–E4 patients showed preserved LTP-like cortical plasticity as compared to A+/T–E3 and to A+/T+ patients independently from genotype (p < 0.001). In addition, A+/T–E4 patients showed a slower cognitive decline with respect to A+/T+ E4 (delta MMSE –0.5±2.12 versus –6.05±4.95; post-hoc p = 0.004) and to A+/T+ E3 patients (–4.12±4.14; post-hoc p = 0.028). No differences were found for SAI protocol (p > 0.05). Conclusion: Our results suggest that APOE4 in patients with isolated Aβ pathology could exert positive effects on LTP-like cortical plasticity with a consequent slower cognitive decline.
derrotabilidade dos princípios enquanto mandamentos de otimização
Authors: Maquiné Dillings Barbosa , Lorenzetto Bruno Meneses
Published: February 2022

Discute-se se os princípios, enquanto espécie normativa, podem ser validamente excepcionados quando, no caso concreto, colidam ou conflitem com outras normas. Ou seja, questiona-se se os princípios são normas derrotáveis, a exemplo do que ocorre com as regras. Parte-se da ideia de princípio enquanto norma de otimização, conforme preconizado na teoria das normas jurídicas de Robert Alexy. Ao mesmo tempo, utiliza-se a noção de derrotabilidade (defeasibility) das normas (ou superabilidade), conceito cujo pioneirismo no Direito é atribuído a Herbert Hart. A discussão contrapõe argumentos contrários à tese da derrotabilidade dos princípios (Robert Alexy; Carsten Bäcker; Thomas Bustamante) e a favor (Ronald Dworkin; Aulis Aarnio; Klaus Günther). O método de abordagem é o dedutivo, enquanto o de procedimento é o comparativo. A técnica adotada é a de pesquisa bibliográfica. Ao final, afirma-se que, enquanto mandamentos de otimizar um fim a ser otimizado, os princípios não são normas derrotáveis.
FUNCTIONS AND CONCEPTS OF CASE MANAGEMENT IN THE WORK OF A PATIENT CARE SPECIALIST
Authors: FRITZKE RENÉ , HIPPE ROMANA
Published: February 2022

The concept of case management is a method of action dedicated to the care of people in the social and health sector. Case management stands for a human service approach that provides the necessary support, treatment, promotion and care to the affected person in sensitive and critical life situations. Individual attention as a person-related service extends to a wide range of applications in the fields of care, rehabilitation, child and youth welfare, family and disability welfare and health care. At the center is "the case" as a construction that represents the affected circumstances of the person in need of help. The task of the case manager is to initiate a caring managerial process of action that corresponds to the situational context of the person seeking help in their social environment. The basic criterion here is a cooperative intersectoral and interdisciplinary, transprofessional collaboration of all human service actors, which constitutes a care network. The intention of the case management process is to effectively and efficiently deal with the problems of the person concerned. The decisive premise for the person to be cared for is the recovery or maintenance of his or her autonomy and sovereignty, which is indicated by the client-related participation and co-creation, the aspect of self-care up to a development of the self-management of the addressee. The conceptual architecture of case management is based on an interdependent double strategy, which on the one hand delineates the action-oriented methods of the person related case level and on the other hand implies a strategic process design on the organizational or system level between the human service providers. The linking of both system levels is exhausted in different case-dependent control variants and fixed process forms, which represent the core elements of methodical action at the case and system level.
ETHICAL AND HUMANITARIAN EXPERTISE: CONCEPTUAL DISTINCTION
Authors: Siniukova Natalya A. , Smirnov Sergei A.
Published: February 2022

The article draws a conceptual distinction between two different institutional forms of assessment of technological innovations in different spheres of human life - between the practices and procedures of ethical expertise and precedent cases of humanitarian expertise. The authors suggest that the aims and objectives of these types of expertise are fundamentally different, despite the precedents in which, in fact, the aims for humanitarian expertise have already been set within the framework of ethical expertise. Ethical expertise implies the inviolability of a person's identity, norms and boundaries. It is called upon to protect human being from all kinds of intrusions and interventions (in medicine, digital environment, education) and treats him or her as a passive object of protection and care. But in an unfolding situation of human identity radical changes, when human beings themselves are choosing the trend of their identity extreme transformation, turning to an application of smart technologies, the task of redefining, restoring human norms and boundaries is being raised. The latter becomes the crucial aim of humanitarian expertise. Accordingly, the role of experts, the design of expertise itself, procedures and normative framework are also changing within these forms of expertise.
HUMANITARIAN PROBLEMS OF DIGITALIZATION IN MEDICINE
Authors: Sidorova Tatiana A.
Published: February 2022

The article highlights humanitarian problems in various areas of digitalization of medicine: the development of distance medicine, with regard to dating and implementation of artificial intelligence. The subject of humanitarian analysis is the informatization and digitalization of healthcare systems, the doctor-patient relationship and their subjectivity, personal identity in the aspect of digitalized possibilities of healthcare. The humanitarian assessment is presented as a binary analysis of the positive and negative consequences of the digitalization of medicine, it is indicated that such an analysis is necessary to ensure the progressive development of biomedicine and the protection of human rights and dignity. The disadvantage of telemedicine is the deepening of medicalization due to the redundancy of proposals and the need for medical advice. Elimination of the doctor's clinical thinking can be the consequence of the implementation of artificial intelligence into medical practice. Algorithmization and patterning in diagnostic and treatment approach contradict the requirement to treat each patient as a unique person. Elimination of uniqueness and contingency in an individual medical history was identified as the main humanitarian problem in the implementation of artificial intelligence. The complexity of formalizing personal aspects in medical cases later leads to errors in the operation of intelligent systems. Many social and ethical issues that arising in the context of the implementation of new digital technologies in medicine manifest the deepening of pre-existing contradictions in the doctor-patient relationship and in the complexity of combining universal knowledge and the uniqueness of a particular medical history.
Penerapan 5S (Seiri, Seiton, Seiso, Seiketsu, Shitsuke) Pada Area Kerja Sebagai Upaya Peningkatan Produktivitas Kerja (Studi Kasus Di CV Widjaya Presisi)
Authors: Reza Muhammad , Azwir Hery Hamdi
Published: February 2022

CV Widjaya Presisi is a small and medium industry engaged in industrial services with its main products being automotive / electronic special tools, dies, jig fixture, stamping, and fabrication. The findings of the problem in the work area are remnants of material that is not removed so that the working space is narrow and no management and supervisors regulate the work environment and work safety. This study aims to implement the 5S design to existing conditions. This study uses a qualitative method, namely the 5S method. The seiri stage is designed by sorting out the equipment that is important, very important, not important and very insignificant. Seiton stage is designed by arranging goods according to the type of goods. The seiso stage is designed by making cleaning areas. The seiketsu stage is designed by providing visual control in the form of labeling, marking, and area boards. The Shitsuke stage is designed by doing activities by making 5S as a rule into the company's standard activity system. After repairs, working time can be optimized from 840 minutes to 810 minutes or a decrease of 4% from work time. The average work productivity in March 2019 and April 2019 amounted to 99.5% where in February 2019 the productivity level was only 57% and experienced a significant increase in March 2019 by 99% and April 2019 by 100%.
Pengendalian Persediaan Bahan Baku Impor dengan Menggunakan Metode EOQ Probabilistik pada Perusahaan Cat Industri
Authors: Ciswondo Ciswondo , Maukar Anastasia Lidya
Published: February 2022

This research was carried out in a manufacturing company producing industrial paints for steel roofing and walling. The level of sales of industrial paint varies and fluctuates depending on product demand from customers. Due to fluctuating demand and forecasting methods for current product demand that is less accurate based only on demand from the previous period, the inventory of imported raw materials has not been optimal. The ARIMA method is used to forecast and then control imported raw material inventories using the probabilistic Economic Order Quantity (EOQ) method to determine the optimal order quantity, safety stock, re-order points and order frequency so as to minimize the total inventory cost. With the probabilistic EOQ method that implements the existence of safety stock will be able to minimize the risk of a shortage of imported raw materials so that the burden of shortage costs can be minimized. The results shows that the proposed method provides a total inventory cost savings of Rp.493,832,731 or obtained a 66% reduce cost compared to the company method
Information System Development Using Microsoft Visual Studio to Speed Up Approved Sample Distribution Process
Authors: Wijaya Carolline Audrel Vellicia , Azwir Hery Hamdi
Published: February 2022

An approved sample is a sample that has been tested in a laboratory and approved by experts who understand it to be a sample in the production process. In the current process, all sample identities are written manually and repeatedly inputted by several people. This manual process is a major bottleneck in producing approved samples so that it can cause delays in the production process. This manual process causes employees to have to work overtime 2-3 hours every day to complete the approved sample which must be issued on the same day. To overcome this problem, an information system was developed to eliminate bottlenecks in this process. Design and development of software use the SDLC method which includes information gathering to find out business processes, DFD analysis, design user interface, ERD and database, and continued with development using Visual Studio, Microsoft Access, Microsoft Excel, and VBA as well as Microsoft Outlook as supporting programs. After the software is implemented it can be seen that the bottlenecks that have occurred so far can be removed and the work completed faster, no additional overtime is required and can even be one day sooner. Besides all the data is stored more neatly and facilitates the process of finding data.
Tantangan Konektivitas dan Aksesibilitas Dalam Pengembangan Pelayanan Kesehatan Berbasis Telemedicine di Indonesia: Sebuah Tinjauan
Authors: Saputro Aditya Rachmat , Gusnadi Amar Ma’aruf , Zanah Zahrotul , Simatupang Joni Welman
Published: February 2022

Kemajuan teknologi telekomunikasi yang pesat telah mempengaruhi dunia medis. Saat ini kita mengenal istilah telemedicine yaitu suatu metode dalam dunia medis yang memanfaatkan teknologi telekomunikasi (termasuk internet)di bidang kesehatan untuk mengirim dan menerima berbagai informasi kedokteran dari tempat satu ke tempat lainnya guna meningkatkan pelayanan klinis dalam mendiagnosa dan terapi kesehatan serta pendidikan medis. Artikel ini merupakan sebuah tinjauan tentang telemedicine yang sudah berkembang di Indonesia dengan cukup signifikan seiring perkembangan jaringan telekomunikasi dan alat untuk mengaksesnya. Metode pada pembahasan ini adalah dengan melakukan berbagai kajian pustaka terkait telemedicine dan teknologi pendukungnya. Sebagai kesimpulan didapatkan bahwa penerapan telemedicine di Indonesia masih terus menghadapi tantangan berupa kondisi konektivitas jaringan telekomunikasi dan ketersediaan perangkat yang memadai untuk mengakses telemedicine. Diharapkan kondisi ini bisa diperbaiki dan ditingkatkan di masa-masa mendatang.

The rapid advancement of telecommunication technology has influenced the medical world. Currently we know the term telemedicine, which is a method in the medical world that utilizes telecommunications technology (including the internet) in the health sector to send and receive various medical information from one place to another in order to improve clinical services in diagnosing and treating health and medical education. This article is an overview of telemedicine which has developed in Indonesia quite significantly along with the development of telecommunication networks and the means to access them. The method in this discussion is to conduct various literature reviews related to telemedicine and its supporting technology. As a conclusion, it can be concluded that the implementation of telemedicine in Indonesia continues to face challenges in the form of conditions of telecommunications network connectivity and the availability of adequate equipment to access telemedicine. It is hoped that this condition can be improved in the future.
Politiques urbaines de la nuit. Entre cultures festives et nuisances sonores à Genève
Authors: Pieroni Raphaël
Published: February 2022

« Après 10 jours d’hospitalisation, la victime vit avec une balle dans les fesses », titre un quotidien suisse à propos d’une fusillade à la sortie d’une discothèque de Genève. Le tireur est un riverain de l’établissement ; exaspéré par les bruits d’une rixe aux portes du lieu en question, il a sorti son fusil de chasse pour mettre un terme aux nuisances. Espace-temps de la ville où cultures festives et nuisances sonores se trouvent en tension, la nuit est tel un baril de poudre, explosant à chacun des heurts entre riverains, tenanciers d’établissements publics, artistes, musiciens et noctambules. Cet ouvrage revient sur l’histoire récente de la construction d’une politique de la nuit à Genève. Il montre comment celles-ci s’inspirent d’expériences conduites dans d’autres villes suisses ou étrangères pour répondre aux problèmes publics nocturnes. Si les politiques urbaines de la nuit ne sont pas chose nouvelle, leur multiplication récente au sein d’échanges mondialisés est un phénomène inédit allant fortement croissant. L’enjeu majeur est de permettre à la nuit de demeurer cet espace-temps de rencontre, de sociabilité, de liberté dans lequel nous expérimentons et construisons nos relations et identités en tous genres. Un objectif qui ne saura être atteint sans initiatives innovantes, entre autres en termes de protection, d’égalité et d’accessibilité
Manajemen Asuhan Kebidanan Post Sectio Caesarea Hari Kedua pada Ny. D dengan Nyeri Luka Operasi
Authors: Lestari Hendring Widya , Machmud Azrida , Hamang Sitti Hardiyanti
Published: February 2022

Pada masa lalu melahirkan dengan cara operasi merupakan hal yang menakutkan karena dapat menyebabkan kematian. Beberapa tahun terakhir ini angka kejadian sectio caesarea meningkat di dunia, tak terkecuali Indonesia. Dengan berkembangnya kecanggihan bidang ilmu kedokteran pandangan tersebut mulai bergeser, sectio caesarea telah menjadi alternatif pilihan persalinan. Ditemukannya bedah sesar memang dapat mempermudah proses persalinan sehingga banyak ibu hamil yang lebih senang memilih jalan ini walaupun sebenarnya bisa melahirkan secara normal. Angka kesakitan dan kematian ibu pada tingkat sectio caesarea lebih tinggi dibandingkan persalinan pervaginam. Sectio Caesarea berkontribusi terhadap angka kematian sekitar 5,8 per 100.000 persalinan, juga angka kesakitan lebih tinggi yakni sekitar 27,3 per 1.000 persalinan, dibandingkan persalinan normal yang hanya 9 per 1.000 persalinan. Angka kesakitan post Sectio Caesarea kira-kira sebesar 15% dan sekitar 90% disebabkan oleh infeksi, maka perubahan fisiologis yang terjadi sangat jelas yaitu nyeri. Tujuan dilakukannya penelitian ini adalah untuk mengetahui tingat nyeri luka Operasi Sectio Caesarea yang dirasakan Ny”D” di RS Pelamonia Makasasar tahun 2019. Jenis penelitian ini bersifat deskriptif dengan menggunakan metode studi kasus Manajemen Kebidanan yang terdiri dari 7 langkah Varney, yaitu : Pengumpulan data dasar, interpretasi data dasar, diagnosa actual,  diagnosa potensial, tindakan segera, rencana asuhan, pelaksanaan asuhan serta mengevaluasi keberhasilannya. Dari kasus Ny”D” yaitu nyeri luka sectio caesarea nyeri belum berkurang namun ibu dapat beradaptasi dengan nyeri (nyeri tingkat 4), tidak terdapat tanda-tanda infeksi. Penelitian ini, bidan dapat menerapkan manajemen asuhan kebidanan sesuai dengan prioritas masalah pasien secara menyeluruh sehingga tindakan yang akan dilakukan bidan dapat dipertanggung jawabkan berdasarkan metode ilmiah.
Manajemen Asuhan Kebidanan pada Ny. E Akseptor IUD dengan Menometroragia
Authors: Daen Atika , Kurnaesih Een , S Suryanti
Published: February 2022

Data WHO menunjukkan bahwa pengguna alat kontrasepsi IUD/AKDR, 30% terdapat di Cina, 13% di Eropa, 5% di Amerika Serikat, 6,7% dinegara– negara berkemabang lainnya. Terdapat peningkatan presentase pemakaian alat kontrasepsi (semua cara) pada Survey Demografi Kesehatan Indonesia (SDKI) dari 62% pada SDKI 2012 menjadi 64% pada SDKI 2017. Namun, presentase putus pakai (Drop Out) kesertaan ber KB masih tinggi yaitu 34%. Kemudian masih besarnya pasangan usia subur (PUS) yang belum terlayani dan belum menggunakan kontrasepsi yang terlihat dari presentase wanita kawin umur 15-49 tahun dengan kebutuhan ber KB yang belum terpenuhi (unmet need) sebesar 11%. Sulawesi selatan cakupan peserta KB aktif di makassar pada tahun 2015. Menujukkan metode kontrasepsi yang terbanyak digunakan adalah suntikan sebanyak 53.200 orang, Pilsebanyak 30.288 orang, Implant sebanyak 14.709 orang, AKDR sebanyak 13.492 orang dan Kondom sebanyak 5.235 orang, Sedangkan metode yang paling sedikit dipilih yaitu, MOP sebanyak 614 orang, MOW sebanyak 4.354 orang (Badan Pusat Statistik, 2016). Tujuan dilakukannya penelitian ini adalah untuk mengetahui dan memahami Asuhan Kebidanan Akseptor KB IUD Pada Ny. “E” Dengan Menometroragia Di RSUD Labuang Baji Makassar tahun 2019 menurut manajemen Varney. Jenis penelitian ini bersifat deskriptif dengan menggunakan metode studi kasus Manajemen Kebidanan yang terdiri dari 7 langkah Varney, yaitu : Pengumpulan data dasar, interpretasi data dasar, diagnosa actual,  diagnosa potensial, tindakan segera, rencana asuhan, pelaksanaan asuhan serta mengevaluasi keberhasilannya dari kasus Ny”E” yaitu tanda-tanda vital dalam batas normal,  menometroragia belum teratasi  namun ibu dapat beradaptasi dengan kondisinya saat ini dan kecemasan teratasi. Penelitian ini, bidan dapat menerapkan manajemen asuhan kebidanan sesuai dengan prioritas masalah pasien secara menyeluruh sehingga tindakan yang akan dilakukan bidan dapat dipertanggung jawabkan berdasarkan metode ilmiah.
Manajemen Asuhan Kebidanan Post Sectio Caesarea Hari Kedua pada Ny. M dengan Nyeri Luka Operasi
Authors: Muliyanti Muliyanti , Hardianti Saputri Linda , Akbar Nurlina
Published: February 2022

Pada tahun 1985 Organisasi Kesehatan Dunia (WHO) menyatakan: "Tidak ada data pasti untuk wilayah yang memiliki tingkat operasi sesar yang lebih tinggi dari 10-15%", melakukan penelitian pembaruan data, untuk perkiraan yang telah diterbitkan WHO sebelumnya tentang angka operasi sesar di seluruh dunia dan menghitung jumlah tambahan operasi sesar yang akan diperlukan di negara-negara dengan jumlah operasi sesar yang rendah serta jumlah operasi sesar yang berlebihanOperasi sesar juga berkontribusi terhadap angka kematian sekitar 5,8  per 100.000 persalinan juga angka kesakitan operasi sesar lebih tinggi, yakni sekitar 27,3 per 1.000 persalinan, dibandingkan persalinan normal yang hanya 9 per 1.000 persalinan. angka kematian ibu pada operasi sesar adalah 40-80/100.000, lebih besar 25 kali dari persalinan normal. Kesakitan post operasi sesar kira-kira sebesar 15% dan sekitar 90% disebabkan oleh infeksi (endometritis, infeksi saluran kemih dan sepsis karena luka). Komplikasi lebih banyak terjadi setelah bedah sesar darurat (kira-kira 25%) dibanding operasi sesar elektif kira-kira 5%. Angka kesakitan post Sectio Caesarea kira-kira sebesar 15% dan sekitar 90% disebabkan oleh infeksi, maka perubahan fisiologis yang terjadi sangat jelas yaitu nyeri. Tujuan dilakukannya penelitian ini adalah untuk mengetahui tingat nyeri luka Operasi Sectio Caesarea yang dirasakan Ny”M” di RS Bhayangkara Makasasar tahun 2019. Jenis penelitian ini bersifat deskriptif dengan menggunakan metode studi kasus Manajemen Kebidanan yang terdiri dari 7 langkah Varney, yaitu : Pengumpulan data dasar, interpretasi data dasar, diagnosa actual,  diagnosa potensial, tindakan segera, rencana asuhan, pelaksanaan asuhan serta mengevaluasi keberhasilannya.Dari kasus Ny”M” yaitu nyeri luka sectio caesarea nyeri belum berkurang namun ibu dapat beradaptasi dengan nyeri(nyeri tingkat 6), tidak terdapat tanda-tanda infeksi.Penelitian ini, bidan dapat menerapkan manajemen asuhan kebidanan sesuai dengan prioritas masalah pasien secara menyeluruh sehingga tindakan yang akan dilakukan bidan dapat dipertanggung jawabkan berdasarkan metode ilmiah.

 

Kata kunci : operasi sesar;nyeri luka;masa  nifas
Crash Prediction Models and Methodological Issues
Authors: Mekonnen Anteneh Afework , Sipos Tibor
Published: February 2022

The conducted literature review aimed to provide an overall perspective on the significant findings of past research works related to vehicle crashes and prediction models. The literature review also provided information concerning past road safety research methodology and viable statistical analysis and computing tools. Though the selection of a specific model hinges on the objective of the research and nature of the response, when compared to statistical modeling techniques, Artificial Neural Networks (ANNs), which can model complex nonlinear relationships among dependent and independent parameters, have been witnessed to be very powerful.
Diseño de herramientas para el desarrollo curricular de la enseñanza de la ética profesional para contadores públicos bajo estándares internacionales de la IFAC
Authors: Amado Piñeros Martha Isabel , Ariza Ruiz Efrén Danilo
Published: February 2022

La presente ponencia busca compartir los resultados obtenidos en el proyecto de investigación “Análisis comparativo de las metodologías de enseñanza de ética profesional para contadores públicos bajo estándares internacionales de la IFAC”, con el animo de desarrollar una serie de herramientas que permitan adecuar el currículo de los programas de Contaduría Pública en la modalidad distancia de la Fundación Universitaria del Área Andina y la Corporación Universitaria Minuto de Dios a los estándares internacionales de educación desarrollados por la IFAC en las norma internacional de educación, número 4, del IESBA. Este aspecto es relevante debido a que el modelo de educación contable debe responder al interés público para asegurar la confianza ante los stakeholders y aumentar la calidad en la producción de la información de la información financiera, aspecto que antes no se visibilizaba desde procesos claros desde el área profesional contable, pero que ahora es relevante, en especial con la entrada en vigencia del Decreto 2132 de 2016 que obliga a adoptar el código de ética de la IFAC, de aquí surge el propósito de esta investigación, al identificar cómo se enseñarían los cursos de ética desde herramientas y estrategias pedagógicas que permitan adecuar la estructura curricular de los programas a tales exigencias.
Análisis estratégico sectorial del sector de los centros comerciales en Bogotá
Authors: Martínez Quintero Geraldine Sofía , Céspedes Gil Alcibíades Alirio
Published: February 2022

La investigación propone realizar un análisis sectorial estratégico del subsector de los centros comerciales de la ciudad de Bogotá, bajo una óptica prospectiva que incluye el análisis de elementos como nivel de hacinamiento cualitativo y cuantitativo, asimetrías financieras, erosión estratégica y de la productividad, crecimiento potencial sostenible entre otras variables con el objeto de concluir respecto a la tendencia estratégica sectorial futura y proponer algunas acciones que eviten la morbilidad del sector.
Manejo clínico-quirúrgico del pie diabético. Un nuevo reto para la Agenda Global 2030 en enfermedades no transmisibles
Authors: Guayán Ardila Ingrid Carolina , Ramírez Espinosa Claudia Marcela , Pardo Patricia
Published: February 2022

Las personas de la tercera edad con mellitus2 (enfermedad no transmisible), reto en la Agenda Global 2030, cuentan con una amplia desigualdad, abandono familiar y social. En Colombia hay 6,4 millones de pacientes diabéticos, y 92 % de ellos son adultos mayores donde el 25 % tuvieron buen control metabólico. Objetivo: determinar las características clínico-quirúrgicas para el manejo del pie diabético en el adulto mayor en una institución prestadora de salud de tercer nivel en Bogotá, Colombia. Metodología: cuantitativo, descriptivo, observacional de corte transversal. Población: adulto mayor con diagnóstico de diabetes mellitus tipo 2, con neuropatía diabética como complicación microvascular, con algún grado de pie diabético. Resultados: no hay asociación estadísticamente significativa entre las variables sociodemográficas (edad, género, tabaquismo, consumo de alcohol, bajo nivel socioeconómico, aislamiento social) y el sometimiento de los pacientes a cualquier tipo de tratamiento quirúrgico. En pacientes que tuvieron un mal control metabólico y mayores de 70 años, se presentó aumento del riesgo a sufrir amputación, como tratamiento quirúrgico. Conclusiones: el diagnóstico y tratamiento del pie diabético continúa siendo un reto para el sistema en salud; es importante que las instituciones de salud conformen grupos interdisciplinarios donde se incluyan el diagnóstico temprano y seguimiento de la patología, identificando los signos de insuficiencia vascular asociada a la diabetes, las deformidades de los artejos que puedan producir áreas de presión que favorezcan la aparición de úlceras. Este grupo será el encargado de promoción y prevención de los signos de alarma.
Metodología invertida para la investigación científica: manual didáctico para el diseño de protocolos de investigación, basado en un algoritmo conceptual. Caso Sistema Educativo Panameño
Authors: Archibold Suárez Raúl , Tuñón Solano Thaiska , Burgos Triana Mauren , Passos Simancas Edgardo , Mapp Ulina
Published: February 2022

El propósito de este texto es el de socializar un manual didáctico orientado por una metodología invertida con algoritmos conceptuales; el mismo, es utilizado en la República de Panamá para la enseñanza y aprendizaje de la metodología de la investigación, específicamente para el diseño de protocolos de investigaciones científica en diferentes instituciones educativas, creada y probada desde el 2015 a septiembre del 2019. La metodología invertida se crea para contribuir al aprendizaje de los estudiantes y docentes panameños, que inicialmente mostraron tener poco conocimiento al diseñar elementos para sus protocolos de investigación, la misma, permite de un manera invertida no tradicional, que los estudiantes pueden diseñar sistematizaciones coherente de algunos elementos para sus proyectos de investigación, la metodología, se subdivide en algunos modelos sistémico conceptuales que han generado el nacimiento de nuevos enfoques, diseños y alcances para la investigación científica. Cabe señalar, que parte y resultados de la aplicación de la metodología invertida, ha sido valorada por algunos expertos investigadores. En agosto de 2019, la SENACYT y Ministerio de Educación de Panamá, seleccionan esta metodología para ser presentada en el Tercer Encuentro de Experiencia de Aula, la misma, ha contribuido a los procesos de acreditación de algunas universidades y a la internacionalización de escuelas de educación primaria en Panamá.
Influencia de los estímulos laborales en los empleados con la productividad empresarial
Authors: Escalante Bourne Teodoro Mauricio , Mackay Castro Clarkent Rubén , Escalante Ramírez Teodoro Antonio , Mackay Véliz Rubén Alberto
Published: February 2022

En la actualidad las organizaciones se tienen que adaptar y enfrentar a los distintos cambios en los mercados, así como también al constante cambio de las tecnologías, con el fin de mantener su rendimiento y productividad, sin embargo, a pesar de estos cambios, las organizaciones mantienen que el instrumento más importante para lograr los resultados esperados, son los empleados, ya que son estos quienes hacen uso de las tecnologías y de la puesta en marcha de los distintos procedimientos y planes de la organización. Para ello las organizaciones deben preocuparse por crear un clima organizacional que satisfaga las expectativas y necesidades, tanto personales como profesionales de sus empleados, así como también idear un plan de motivación y estimulo laboral, que se traduzca en contar con un personal que realice un desempeño laboral que se identifique y cumpla con la misión y visión de la organización, y de esta forma lograr que en conjunto organización y empleados, alcancen sus metas fijadas.
Penerapan Sistem Daya Cadangan Untuk Lemari Vaksin Menggunakan PLTS Pada Puskesmas Sindangbarang Bogor
Authors: Dini Hasna Satya , Mowaviq Muhamamd Imbarothur , Purwanto Sugeng , Junaidi Andi , Pawenary Pawenary , Rahayu Sofitri
Published: February 2022

The temperature stability of the vaccine needs to be designed in such a way as to maintain its quality. Where vaccines are generally placed in a special refrigerator with an internal temperature of around +20C - +80C. The condition of the electricity network in the Bogor area, which sometimes goes out for a long time can cause electricity to not be supplied for vaccine refrigerators. For a long period of time, this condition can cause damage to the vaccine so that it cannot be given to toddlers. This activity is the application of technology that is very useful for the people of the Bogor, especially for the Sindangbarang Health Center in Bogor related to the design of power reserves, especially for vaccine refrigerators. This power backup system uses various equipment with appropriate technology such as Automatic Transfer Switch (ATS), solar panels, inverters, batteries, solar charge controllers and other supporting equipment. This PKM program has a focus on managing backup power systems in vaccine cabinets using solar power plants
Fi. kupias
Authors: Kalima Jalo
Published: February 2022

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Über die nicht-etymologischen Laute der finnisch-ugrischen Sprachen
Authors: Nyirkos István
Published: February 2022

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Maternal Obesity and the Risk of Selected Foetal Abnormalities (Neural Tube Defects and Orofacial Clefts) In Malaysia: A Retrospective Observational Study
Authors: Bah Yi Rou , Yan Lye Glenn Jing , Gunaravi Sisyena Anusha , Toh Steven , Vijayan Vigneswari , En Ting Grace Soon , Tham Su Ming , Dominic Nisha Angela , Jeganathan Ravichandran , Thirunavuk Arasoo Valliammai Jayanthi
Published: February 2022

Objective: To evaluate the association between maternal obesity and the risk of selected foetal abnormalities (neural tube defects and orofacial clefts) in Malaysia. Materials and Methods: We conducted a single-centre retrospective observational study on all women who delivered at Hospital Sultanah Aminah Johor Bahru, Malaysia from 1st January 2017 to 31st December 2018. The presence of neural tube defects (NTD) and orofacial clefts (OC) were identified from medical records, including all live births, stillbirths and terminations of pregnancy. All deliveries during the study period were reviewed to collect data on maternal weight, height and demographics. We performed multiple logistic regression to estimate factors contributing to selected anomalies. Results: A total of 28,228 pregnancies were included. There were 57 NTD-affected pregnancies and 34 OCaffected pregnancies identified during the two-year study period. There was no statistically significant association found between maternal obesity and the occurrence of NTDs or OCs. Pre-gestational diabetes had a significant association with NTD-affected pregnancies (aOR 3.454, 95% CI [1.017, 11.725], p=0.091). The highest incidence rate of NTDs was among Malaysian Indians (2.540 per 1,000 deliveries). Malaysian Chinese and Malaysians of other ethnicities were found to have a significantly higher risk of having OC-affected pregnancies with aOR of 2.371 (95% CI [1.035-5.428], p=0.024) and 4.910 (95% CI [1.454-16.579], p=0.024) respectively. Conclusion: Our study showed no significant association between maternal obesity and selected foetal abnormalities (NTD and OC), and that pre-gestational diabetes is a significant risk factor for NTD in Malaysia.
Dielectric Behavior and Transport Properties of Electrospun Polyvinylidene Fluoride Nanofiber Membrane
Authors: Palwai Sharvare , Batra Ashok , Arun K. J. , Vaseashta Ashok
Published: February 2022

Poly (vinylidene fluoride) (PVDF) is a chemical resistance polymer with high ferroelectric, piezoelectric and pyroelectric properties. PVDF has been chosen due to its unique properties compared with others in the polymers family and is used in a variety of sensors and transducers. A PVDF nanofiber membrane with relatively uniform morphology was prepared by an electrospinning technique. The surface morphology of the electrospun PVDF nanofibers was observed by scanning electron microscopy (SEM). The microstructure of electrospun PVDF nanofibers was characterized by Fourier Transform Infrared spectroscopy (FTIR) in the range 400 to 4000 cm-1. The functional groups were identified in the membrane. Infrared vibrational spectroscopy (FTIR + Raman) curves revealed a ferroelectric β-phase in the un-annealed membrane intrinsically. It showed that the electrospinning technique induce crystalline and polar β-phase by applying an electric field to the PVDF polymer solution during high solution jet stretching. The membrane (7 mm x5 mm) with full-face copper electrodes was produced to form a capacitor for testing.
Effect of IgG3 Hinge Region Length Polymorphisms on Iron Fortification among Rural Pre-School Ghanaian Children and Its Associated Risk to Malaria and Anaemia.
Authors: Tchum Samuel Kofi , Arthur Fareed , Sakyi Samuel Asamoah , Gyan Thomas , Dzabeng Francis , Amoani Benjamin , Tanumihardjo Sherry A.
Published: February 2022

Sub-Saharan African pre-school children have an interdependence among immune response, infection resistance and adaptive effect of the dietary intake. However, the long hinge region of immunoglobulin G3 makes binding easy to malaria antigens and receptors, eliciting a more protective response among subclasses of immunoglobulin G. However, it is unknown if iron-containing multimicronutrients are associated with risk of anaemia and malaria in pre-school children with hinge region G3 immunoglobulin polymorphism living in high malaria transmission areas. We aimed to determine the impact of iron fortification in pre- chool children with immunoglobulin G3 hinge region length polymorphisms and their associated risk of malaria and anaemia in rural Ghana. This retrospective controlled, double blind, randomized population study was conducted over six months in rural Ghana among 6 to 35-month-old infants and young children. Participants were randomly allocated either ironfree multimicronutrients powder (placebo group) or iron (intervention group; 12.5 mg iron daily) into clusters where mixed semi-liquid homemade meals were delivered daily for 5 months. Anti-malaria mosquito bed nets and anti-malaria treatment were readily available during the study. Standardized therapeutic and epidemiological questionnaires were administered. Participants’ blood samples were assessed for immunoglobulin G3 hinge region length polymorphism, full blood count, anthropometry, and malaria microscopy. Baseline anthropometry, anaemia, iron status, demographic characteristics and dietary consumption were similar (p > 0.05). 27.85 % were venerable to clinical malaria at baseline. Homozygote medium polymorphism had the maximum frequency of 48 %, followed by homozygote long polymorphism (43 %), heterozygote long-medium polymorphisms (7.0 %) and relatively few were homozygote short 2.0 % with similarities between the study groups (p = 0.14; HardyWeinberg equilibrium estimate, χ2 analysis). However, iron fortification did not influence the risk of aneamia and malaria among participants with immunoglobulin G3 hinge region length polymorphisms but was not detrimental to participants.
Antibacterial Effect of Turkish Black Cumin Seed Oil Against Pathogen Bacteria's
Authors: Guldal Ilyas , Karabiyikli Seniz
Published: February 2022

Black cumin seeds are used for medicinal and aromatic purposes in Turkey. Black cumin seed oil (BSCO) was provided from a local producer. BCSO was extracted by cold-pressing method. Antibacterial effect of BCSO was investigated against B. cereus (ATCC 10876), L. monocytogenes (ATCC 19115), E. coli (ATCC 25922), Salmonella Thypimurium (ATCC 14028) and S. aureus (ATCC 25923) by minimum inhibitory concentration (MIC) method. MIC values were determined according to micro tube dilution method. BCSO had antibacterial effect against B. cereus and S. aureus and didn’t have antibacterial effect against other bacterias. B. cereus and S. aureus are Gram (+) and others are Gram (-). In various studies, it had been found that Gram (+) bacterias are less resistance to aromatic oils. Fatty acid composition of BCSO was investigated for additional information of material and major fatty acids of BCSO are linoleic acid, oleic acid and palmitic acid. As a results, study suggests that cold-pressed BCSO can be used for its functional property. Pract?cal Appl?cat?ons Black seed oil is widely used in ethnopharmacology. It is marketed as a treatment agent for many mild diseases in the shops called "Aktar" in Turkish culture and it finds a response by the public. However, its use in industry is limited due to its pungent odor and taste. In this study, the functional properties of black cumin oil were investigated.
Antimicrobial Activity by a Unique Composition of Cold Pressed Nigella Sativa Seed (Black Cumin) Oil
Authors: Navit Ogen-Shtern , Margarita Yarmenko , Liki von Oppen-Bezalel
Published: February 2022

The oil produced from Nigella sativa seeds (black cumin) is a known folklore remedy for treatment of various health conditions, including the treatment of microbial infections. The microbes Malassezia furfur, Candida albicans and Staphylococcus aureus are commonly found in healthy skin and gut microbiota, but can also be infection-inducing microorganisms upon overgrowth, capable of disrupting the homeostasis of the microbiome. Treatment with antibiotics has led some of these microbes to evolve antibiotic-resistant strains. Several Nigella sativa oils produced by cold pressing of agricultural crops to contain high or low amounts of the active molecule, thymoquinone as well as high or low amounts of free fatty acids were tested for their antifungal and antibacterial properties. The growth of Malassezia furfur and an antibiotic-resistant strain of Candida albicans were most inhibited by a combination of high amounts of Thymoquinone (3%) and low amounts of free fatty acids (2%). While the growth of Staphylococcus aureus is strongly inhibited by Nigella sativa oil, it seems that another component, yet to be identified, is responsible for the antibacterial effect as all oil compositions tested presented similar and strong inhibition of the bacterial growth. According to the results, Nigella sativa oil may be used as an alternative safe antimicrobial agent, and perhaps even as a preventative care for maintenance of microbiome balance and diversity.
Magnetic Nanoparticles: An Optimization Design Approach for a Targeted Drug Release Using an AC Magnetic Field
Authors: Sackeyfio Stephanie T N A , McGinley Shawn Michael , Sinha Saion
Published: February 2022

Magnetic Nanoparticles while very versatile, show a promising and innovative method in drug targeting to help increase efficacy. The optimization of magnetic nanoparticles through the application of an AC magnetic field will enhance the release of cytotoxic drugs at the target area whilst preventing effects on healthy tissues. This article presents a study that describes the development of a Manganese Iron Oxide (MnFe2O4) magnetic nanoparticle showing a therapeutic effect on T47D cells using Doxorubicin in a DC magnetic field. It also introduces and dissects the core of magnetic nanoparticles, its applications as well as the breakdown of a design approach that can be employed to enhance drug delivery to localized sites. In addition, it shows a comprehensive technique through mathematical modeling and discusses the AC susceptibility of these unique drug vehicles; magnetic nanoparticles.
Prevalência de vulvovaginites em mulheres da zona rural
Authors: Rodrigues Herica Jovita Carvalho , Silva Helena Filomena Moraes da , Pereira Luana da Silva , Castro Glayr de Jesus Batista , Silva Sâmia Amélia Mendes , Araújo Eleilde Almeida , Lopes Dinaelze Abrão , Pinho Jaqueline Diniz
Published: February 2022

As vulvovaginites são as causas mais comuns de corrimento vaginal em mulheres, e as principais consequências associadas estão: infertilidade, parto prematuro ou recém-nascido de baixo peso, aborto, endometrite pós-cesárea, aumento do risco de contrair doenças de transmissão sexual, como a AIDS, gonorréia, tricomoníase, entre outras. Neste contexto, o objetivo deste trabalho foi identificar a prevalência de vulvovaginites em mulheres lavradoras atendidas em uma Unidade Básica de Saúde (UBS) oriundas da zona rural do interior do Maranhão. Para isso, foi realizado um estudo retrospectivo, transversal e descritivo, realizado com mulheres que buscaram atendimento em uma UBS atendidas durante os anos de 2018 e 2020. De acordo com os dados levantados, predominaram mulheres com mais de 51 anos (28,57%), lavradoras (61%), que se queixaram de leucorreia, e apresentaram no resultado do exame: Gardnerella, Candida e HPV. Os dados apresentados neste trabalho demonstram como a educação em saúde para as mulheres, em especial para aquelas que possuem baixo acesso aos serviços de saúde, é mandatória. Isso permitirá que a busca por atendimento ginecológico ocorra de forma precoce, visto que alguns dos agentes causadores das vulvovaginites, como o HPV, estão associados a vários tipos de cânceres.
Desafios e métodos na gestão da empresa familiar
Authors: Brito Thiago Silva , Ongaratto Jhonata , Bueno Miriam Pinheiro
Published: February 2022

As empresas familiares possuem elevada importância no desenvolvimento da economia, pois representam uma parte significativa do PIB (produto interno bruto) e são responsáveis por gerar milhões de empregos no mundo. A gestão de todas as empresas apresenta alguns objetivos em comum, porém as empresas de origem familiar apresentam certas peculiaridades devido aos seus vínculos. O objetivo foi apresentar aspectos importantes na gestão de empresas familiares, abordando temas que poderiam representar desafios em sua gestão e propor métodos para sua resolução. Utilizou-se os processos metodológicos qualitativo, exploratório, descritivo e bibliográfico. Foram avaliados na literatura o processo sucessório, a importância da tradição e valores da família e a tomada de decisão. Os resultados apontam que o processo sucessório eficiente depende de planejamento e profissionalização do sucessor. Concluiu-se que há métodos eficazes estabelecidos para auxiliar a tomada de decisão de empresas familiares de forma a minimizar a influência de conflitos de interesse da família. E o presente trabalho também ressalta a importância de preservar os valores da organização familiar.
CT Evaluated Sarcopenia Signals: Shorter Survival for Small Cell Lung Cancer Patients
Authors: PEKAŘOVÁ A , PEKAŘ M , DANIŠ D , NOVÁKOVÁ Z
Published: February 2022

Sarcopenia is an independent risk factor for morbidity and mortality in patients suffering from small cell lung cancer (SCLC), however, a universal indicator of sarcopenia usable in clinical practice is still missing. A novel indicator for describing the severity of cancer could be helpful in tailoring the anti-tumor therapy. The aim of this study was to evaluate the computed tomography (CT) scans of total muscle area and radiation attenuation in patients suffering from small cell lung cancer. We used staging CT scans performed at the time of diagnosis to measure total muscle area (TMA) and average psoas density (PD) at level of the 3rd lumbar vertebra. TMA and PD were statistically evaluated in association with overall survival and disease staging. We used Mann-Whitney test and Spearman´s correlation coefficient for statistical testing and p-value under 0.05 was considered statistically significant. Retrospectively we examined 47 patients suffering from SCLC (mean age 65.05±7.3 years, BMI 23.97±4.4 kg/m2, BSA 1.77±0.2 m2, 30-day mortality was 4.3 % with 10 months median survival). As sarcopenia was pointed TMA under 55 and 39 cm2/m2 for men and women respectively. The sarcopenic patients had significantly shorter median survival (7 vs. 11 months, p=0.05). We observed a significant relationship between survival and performance status (Spearman´s correlation, R=-0.39, p=0.05). The patients were divided into two groups according to the extensive (ED, n=34) or limited (LD, n=13) form of the disease. We observed significant difference in PD (42.49±6.1 vs. 47.67±4.5 HU, p=0.006) between ED vs. LD groups.