bluuebunny/crossref_metadata_2025 huggingface dataset:
Genetic Determinants in a Critical Domain of NS5A Correlate with Hepatocellular Carcinoma in Cirrhotic Patients Infected with HCV Genotype 1b
Authors: Alkhatib Mohammad , Di Maio Velia , De Murtas Valentina , Polilli Ennio , Milana Martina , Teti Elisabetta , Fiorentino Gianluca , Calvaruso Vincenza , Barbaliscia Silvia , Bertoli Ada , Scutari Rossana , Carioti Luca , Cento Valeria , Santoro Maria , Orro Alessandro , Maida Ivana , Lenci Ilaria , Sarmati Loredana , Craxì Antonio , Pasquazzi Caterina , Parruti Giustino , Babudieri Sergio , Milanesi Luciano , Andreoni Massimo , Angelico Mario , Perno Carlo , Ceccherini-Silberstein Francesca , Svicher Valentina , Salpini Romina ,   on behalf of HIRMA (Hepatocarcinoma Innovative Research MArkers) and Fondazione Vironet C (HCV Virology Italian Resistance
Published: April 2021

HCV is an important cause of hepatocellular carcinoma (HCC). HCV NS5A domain-1 interacts with cellular proteins inducing pro-oncogenic pathways. Thus, we explore genetic variations in NS5A domain-1 and their association with HCC, by analyzing 188 NS5A sequences from HCV genotype-1b infected DAA-naïve cirrhotic patients: 34 with HCC and 154 without HCC. Specific NS5A mutations significantly correlate with HCC: S3T (8.8% vs. 1.3%, p = 0.01), T122M (8.8% vs. 0.0%, p < 0.001), M133I (20.6% vs. 3.9%, p < 0.001), and Q181E (11.8% vs. 0.6%, p < 0.001). By multivariable analysis, the presence of >1 of them independently correlates with HCC (OR (95%CI): 21.8 (5.7–82.3); p < 0.001). Focusing on HCC-group, the presence of these mutations correlates with higher viremia (median (IQR): 5.7 (5.4–6.2) log IU/mL vs. 5.3 (4.4–5.6) log IU/mL, p = 0.02) and lower ALT (35 (30–71) vs. 83 (48–108) U/L, p = 0.004), suggesting a role in enhancing viral fitness without affecting necroinflammation. Notably, these mutations reside in NS5A regions known to interact with cellular proteins crucial for cell-cycle regulation (p53, p85-PIK3, and β-catenin), and introduce additional phosphorylation sites, a phenomenon known to ameliorate NS5A interaction with cellular proteins. Overall, these results provide a focus for further investigations on molecular bases of HCV-mediated oncogenesis. The role of theseNS5A domain-1 mutations in triggering pro-oncogenic stimuli that can persist also despite achievement of sustained virological response deserves further investigation.
Transaminase Elevations during Treatment of Chronic Hepatitis B Infection: Safety Considerations and Role in Achieving Functional Cure
Authors: Vaillant Andrew
Published: April 2021

While current therapies for chronic HBV infection work well to control viremia and stop the progression of liver disease, the preferred outcome of therapy is the restoration of immune control of HBV infection, allowing therapy to be removed while maintaining effective suppression of infection and reversal of liver damage. This “functional cure” of chronic HBV infection is characterized by the absence of detectable viremia (HBV DNA) and antigenemia (HBsAg) and normal liver function and is the goal of new therapies in development. Functional cure requires removal of the ability of infected cells in the liver to produce the hepatitis B surface antigen. The increased observation of transaminase elevations with new therapies makes understanding the safety and therapeutic impact of these flares an increasingly important issue. This review examines the factors driving the appearance of transaminase elevations during therapy of chronic HBV infection and the interplay of these factors in assessing the safety and beneficial nature of these flares.
From Multiplex Serology to Serolomics—A Novel Approach to the Antibody Response against the SARS-CoV-2 Proteome
Authors: Butt Julia , Murugan Rajagopal , Hippchen Theresa , Olberg Sylvia , van Straaten Monique , Wardemann Hedda , Stebbins Erec , Kräusslich Hans-Georg , Bartenschlager Ralf , Brenner Hermann , Laketa Vibor , Schöttker Ben , Müller Barbara , Merle Uta , Waterboer Tim
Published: April 2021

The emerging SARS-CoV-2 pandemic entails an urgent need for specific and sensitive high-throughput serological assays to assess SARS-CoV-2 epidemiology. We, therefore, aimed at developing a fluorescent-bead based SARS-CoV-2 multiplex serology assay for detection of antibody responses to the SARS-CoV-2 proteome. Proteins of the SARS-CoV-2 proteome and protein N of SARS-CoV-1 and common cold Coronaviruses (ccCoVs) were recombinantly expressed in E. coli or HEK293 cells. Assay performance was assessed in a COVID-19 case cohort (n = 48 hospitalized patients from Heidelberg) as well as n = 85 age- and sex-matched pre-pandemic controls from the ESTHER study. Assay validation included comparison with home-made immunofluorescence and commercial enzyme-linked immunosorbent (ELISA) assays. A sensitivity of 100% (95% CI: 86–100%) was achieved in COVID-19 patients 14 days post symptom onset with dual sero-positivity to SARS-CoV-2 N and the receptor-binding domain of the spike protein. The specificity obtained with this algorithm was 100% (95% CI: 96–100%). Antibody responses to ccCoVs N were abundantly high and did not correlate with those to SARS-CoV-2 N. Inclusion of additional SARS-CoV-2 proteins as well as separate assessment of immunoglobulin (Ig) classes M, A, and G allowed for explorative analyses regarding disease progression and course of antibody response. This newly developed SARS-CoV-2 multiplex serology assay achieved high sensitivity and specificity to determine SARS-CoV-2 sero-positivity. Its high throughput ability allows epidemiologic SARS-CoV-2 research in large population-based studies. Inclusion of additional pathogens into the panel as well as separate assessment of Ig isotypes will furthermore allow addressing research questions beyond SARS-CoV-2 sero-prevalence.
Survey-Based Analysis of Current Trends for Prescribing Gastrointestinal Protectants among Small-Animal General Practitioners in Portugal
Authors: Baptista Rita , Englar Ryane , São Braz Berta , Leal Rodolfo
Published: April 2021

In both human and veterinary healthcare, gastrointestinal protectants (GIPs) are considered a staple of clinical practice in that they are prescribed by general practitioners (GPs) and specialists alike. Concerning GIP use, overprescription of proton pump inhibitors (PPIs) has become a growing concern among human healthcare providers. This trend has also been documented within veterinary practice, prompting the American College of Veterinary Internal Medicine (ACVIM) to publish a consensus statement in 2018 concerning evidence-based indications for GIP use. This observational cross-sectional study evaluated self-reported prescribing protocols among Portuguese GPs to determine whether there is adherence to the consensus guidelines. Respondents were Portuguese GPs recruited by social media posts in veterinarian online forums. Data were collected from 124 respondents concerning their GIPs of choice and their rationales for prescribing them. Data were mined for prescription patterns and protocols. Among GIPs, PPIs were prescribed more often. Rationales for use included gastrointestinal ulceration and erosion (GUE), prophylactic management of nonerosive gastritis, pancreatitis, reflux esophagitis, and steroid-induced ulceration. Once-daily administration of PPIs was the most frequent dosing regime among respondents. Ninety-six percent of PPI prescribers advocated that the drug be administered either shortly before or at mealtime. Forty-nine percent of respondents supported long-term use of PPIs. Fifty-nine percent of respondents acknowledged discontinuing PPIs abruptly. This study supports that Portuguese GPs commonly prescribe GIPs in accordance with ACVIM recommendations to medically manage GUE. However, misuse of GIPs does occur, and they have been prescribed where their therapeutic value is debatable. Educational strategies should target GPs in an effort to reduce GIP misuse.
Preoperative Variables Associated with Surgical Outcome for the Correction of Exodeviation
Authors: Salh Dominique , Walsh Leah , Hahn Erik , La Roche Robert
Published: April 2021

The success rate of exodeviation surgery in existing literature has been shown to be variable. This study sought to determine the success rate of surgery for exodeviation in Atlantic Canada and determine variables associated with surgical outcome. A retrospective chart review was performed, considering patients who had been assessed and surgically treated for exodeviation at the IWK Health Centre between 2011–2018. This study included 176 subjects, aged 1–75 years. Preoperative variables were compared between subjects with successful versus unsuccessful surgical outcomes, using the chi square, Fischer’s exact test and binary logistic regression. A success rate of 43% was determined. Smaller preoperative deviation size at near and distance fixation, as well as the basic type classification were associated with successful operative outcome. Left eye acuity showed a statistically significant association with surgical success outcome. In conclusion, these findings compliment those of previous groups, suggesting exodeviation surgery outcome is variable. Our results add to a growing list of variables implicated in outcomes for these subjects. A smaller deviation preoperatively was associated with success in existing data and in this study, and these findings may suggest a potential role for basic subtype into future exodeviation literature.
Zooplankton Community Structure in Shallow Saline Steppe Inland Waters
Authors: Zsuga Katalin , Inelova Zarina , Boros Emil
Published: April 2021

Several shallow saline waters can be found in Central Asia in arid steppe climate, but our knowledge of their zooplankton community has been so far rather limited. The aim of our research was to provide data on the steppe zooplankton community in a large-scale regional study. Therefore, a baseline survey was carried out in 23 shallow inland waters of different salinity in Northern Kazakhstan. We measured the quantity and identified the taxonomic composition of zooplankton in the spring period and examined changes in community structure in correlation with salinity. Lesser salt concentration of the hyposaline–mesosaline waters was indicated by the presence of halophilic rotifer species: Brachionus asplanchnoides, Br. dimidiatus, Br. plicatilis. Mesosaline and hypersaline waters were indicated by the presence of halobiont crustaceans: Moina salina, Arctodiaptomus salinus, Cletocamptus retrogressus. Very high concentration of salt was indicated by presence of Artemia alone which is the only group, that can tolerate and adapt to this extreme environment. In the hypersaline waterbodies at over 79 gL−1 high TDS conditions a very simple tropical structure was found. Artemia playing monopolistic ecological function in the zooplankton community. We identified three characteristic groups of shallow inland saline waters based on their zooplankton composition.
Evaluation of Hybrid Constructed Wetland Performance and Reuse of Treated Wastewater in Agricultural Irrigation
Authors: Šereš Michal , Innemanová Petra , Hnátková Tereza , Rozkošný Miloš , Stefanakis Alexandros , Semerád Jaroslav , Cajthaml Tomáš
Published: April 2021

Agriculture is being negatively affected by the decrease in precipitation that has been observed over the last few years. Even in the Czech Republic, farmers are being urged to irrigate their fields despite the fact that sources of water for irrigation are rapidly being depleted. This problem might be partially solved via the reuse of treated wastewater in certain agricultural sectors. However, the public perception of the reuse of wastewater remains negative primarily due to unknown risks to the environment and public health. To overcome this barrier, a semi-operated irrigation field was established at Kostelec nad Ohří in the Central Bohemian region of the Czech Republic and planted with common garden crops such as tomatoes (Lycopersicon esculentum), potatoes (Solanum tuberosum) and lettuces (Lactuca sativa L.) irrigated with two different water sources, i.e., treated wastewater from a local nature-based treatment system, a hybrid constructed wetland (HCW), and local fresh water from well. The HCW was put into operation in 2017 and was reconstructed in 2018 and includes both horizontal and vertical flow beds; the trial irrigation field was added in the same year. The reconstruction of the facility significantly enhanced the removal efficiency with respect to all monitored parameters, e.g., biochemical oxygen demand (BOD5), chemical oxygen demand (COD), N–NH4+, total N and the suspended solids (TSS), except for total P. The HCW also ensured the significant removal of several observed pathogenic microorganisms (E. coli, intestinal enterococci and thermotolerant coliforms). During the 2018 and 2019 growing seasons, we observed the significantly enhanced growth of the crops irrigated with wastewater from the HCW due to the fertilizing effect. The risks associated with the contamination of crops irrigated with treated water are not negligible and it is necessary to pay sufficient attention to them, especially when introducing irrigation with wastewater into practice.
A New Algorithm for Monitoring Backflow from River to Lake (BRL) Using Satellite Images: A Case of Poyang Lake, China
Authors: Jiang Hui , Liu Yao , Lu Jianzhong
Published: April 2021

Backflow from river to lake (BRL) usually happens in inland lakes and affects water exchange, matter migration, and variations in the water quality and eco-environment. However, at present, discharge data derived from hydrological stations are the only way to monitor BRL, and the influence scope of BRL has not been monitored through hydrological stations. To address this problem, we propose a novel algorithm to monitor BRL using satellite images of Poyang Lake (the largest freshwater lake in China). The following results were obtained: (1) According to the difference in suspended sediment from rivers and lakes, an algorithm using the total suspended sediment (TSS), which was used as a tracer, was designed for monitoring BRL in Poyang Lake. (2) An innovative extraction method for the mutation line using the TSS was developed to analyze BRL via satellite images. A gradient variation method was developed to extract the mutation line accurately. (3) The satellites with daily acquisition or higher-frequency resolution images (e.g., Moderate-Resolution Imaging Spectroradiometer (MODIS)) were satisfactory for monitoring the characteristics of BRL. The MODIS-derived band combination Rrs(645) − Rrs(859))/(Rrs(555) − Rrs(859) yielded a higher fitting accuracy (R2 = 0.858, RMSE = 10.25 mg/L) derived from an exponential model, which was helpful to highlighting the mutation line. (4) The important parameters of BRL, such as the beginning time, the duration, the end time, and the influence scope, were quantitatively determined by judging the movement of the mutation line. This algorithm was applied to quickly and effectively extract the information of two instances of BRL in Poyang Lake in July 2000 and July to August 2007, and the results were accurate and reasonable. This algorithm can save a great deal on monitoring costs. A BRL monitoring algorithm using remote sensing is an efficient government measure supplement to address the limitations of hydrological stations. These results provide technological support for lake management and can serve as a valuable reference for water bodies similar to Poyang Lake worldwide.
Pinhole Multistep Centrifuge Outflow Method for Estimating Unsaturated Hydraulic Properties with Small Volume Soil Samples
Authors: Bui Long Thanh , Mori Yasushi
Published: April 2021

If soil hydraulic conductivity or water holding capacity could be measured with a small volume of samples, it would benefit international fields where researchers can only carry a limited amount of soils out of particular regions. We performed a pinhole multistep centrifuge outflow method on three types of soil, which included granite decomposed soil (Masa soil), volcanic ash soil (Andisol soil), and alluvial clayey soil (paddy soil). The experiment was conducted using 2 mL and 15 mL centrifuge tubes in which pinholes were created on the top and bottom for air intrusion and outflow, respectively. Water content was measured at 5, 15, and 30 min after applying the centrifuge to examine the equilibrium time. The results showed that pinhole drainage worked well for outflow, and 15 or 30 min was sufficient to obtain data for each step. Compared with equilibrium data, the retention curve was successfully optimized. Although the curve shape was similar, unsaturated hydraulic conductivities deviated largely, which implied that Ks caused convergence issues. When Ks was set as a measured constant, the unsaturated hydraulic properties converged well and gave excellent results. This method can provide soil hydraulic properties of regions where soil sampling is limited and lacks soil data.
Economic Sustainability of Small-Scale Hydroelectric Plants on a National Scale—The Italian Case Study
Authors: Raimondi Anita , Bettoni Filippo , Bianchi Alberto , Becciu Gianfranco
Published: April 2021

The feasibility of hydroelectric plants depends on a variety of factors: water resource regime, geographical, geological and environmental context, available technology, construction cost, and economic value of the energy produced. Choices for the building or renewal of hydroelectric plants should be based on a forecast of the future trend of these factors at least during the projected lifespan of the system. In focusing on the economic value of the energy produced, this paper examines its influence on the feasibility of hydroelectric plants. This analysis, referred to as the Italian case, is based on three different phases: (i) the economic sustainability of small-scale hydroelectric plants under a minimum price guaranteed to the hydroelectric operator; (ii) an estimate of the incentives for reaching the thresholds of “acceptability” and “bankability” of the investment; (iii) an analysis of the results obtained in the previous phases using a model of the evolution of the electricity price over the 2014–2100 period. With reference to the Italian case, the analysis suggests that, to maintain the attractiveness of the sector, it is necessary to safeguard the access to a minimum guaranteed price. With the current tariff plan, complete sustainability is only achieved for plants with p ≤ 100 kW. For the remaining sizes, investments under current conditions would not be profitable. The extension of minimum guaranteed prices could make new medium-large plants (500–1000 kW) more attractive. The current incentive policy is not effective for the development of plants larger than 250 kW, as systems with lower capital expenditures are preferred. Uncertainty about the evolution of the price of energy over time is a concern for the sector; the use of evolutionary models of technical economic analysis tried to reduce these criticalities, and it was shown that they can be transformed into opportunities. It was also found that profitability due to the growing trend expected for the price of energy cannot be highlighted by a traditional analysis.
Temporal and Spatial Characteristics of CO2 Flux in Plateau Urban Wetlands and Their Influencing Factors Based on Eddy Covariance Technique
Authors: Wu Yi , Mao Xufeng , Zhang Zhifa , Tang Wenjia , Cao Guangchao , Zhou Huakun , Ma Jianhai , Yin Xinan
Published: April 2021

Urban wetlands, an important part of the urban ecosystem, play an important role in regional carbon cycles and the carbon balance. To analyze the CO2 source and sink effects of plateau urban wetlands, based on the data measured by an eddy covariance instrument, the temporal and spatial characteristics of CO2 flux and their influencing factors in the urban wetland of Xining City in the Qinghai Province of China during a warm season (July to September 2020) were studied. The results show that: (1) On the daily scale, the CO2 flux exhibited an obvious “U”-type variation, characterized by strong uptake in the daytime and weak emission at night, with an average daily flux of −0.05 mg·m−2·s−1. The CO2 uptake peak of the wetland took place at 13:00 (−0.62 mg·m−2·s−1), and the emission peak occurred at 23:30 (0.34 mg·m−2·s−1); (2) on the monthly scale, the CO2 flux of the wetland in the study period showed a net uptake each month. The flux increased month by month, and the maximum value occurred in September (−142.82 g·m−2·month−1); (3) from a spatial point of view, the river area showed a weak CO2 uptake (−0.07 ± 0.03 mg·m−2·s−1), while the artificial wetland area showed a strong CO2 uptake (−0.14 ± 0.03 mg·m−2·s−1). The former was significantly lower than the latter (p < 0.01); (4) the regression analysis results show that the CO2 flux was significantly correlated with PAR, VPD, Tsoil, and SWC (p < 0.01). The relationships between the flux and PAR, Tsoil, and SWC were rectangular hyperbola (y = 0.2304 − 2 × 10−3x/(0.9037 + 0.0022x), R2 = 0.64), exponential (y = 0.046exp(0.091x), R2 = 0.88), and quadratic (y = −0.0041x2 + 0.1784x − 1.6946, R2 = 0.83), respectively. Under the joint action of various environmental factors, the urban wetland ecosystem in plateau displayed a strong carbon sink function in warm seasons. This study can establish a data scaffold for the accurate estimation of carbon budget of this type of ecosystem.
Machine Learning Modeling of Climate Variability Impact on River Runoff
Authors: Norel Mateusz , Krawiec Krzysztof , Kundzewicz Zbigniew W.
Published: April 2021

The hypothesis of this study was one of existence of spatially organized links between the time series of river runoff and climate variability indices, describing the oscillations in the atmosphere–ocean system: ENSO (El Niño–Southern Oscillation), PDO (Pacific Decadal Oscillation), AMO (Atlantic Multidecadal Oscillation), and NAO (North Atlantic Oscillation). The global river flow reconstructions (ERA-20-CM-R) for 18 study areas on six continents and climate variability indices for the period 1901–2010 were used. The split-sample approach was applied, with the period 1901–2000 used for training and 2001–2010 used for testing. The quality measures used in this paper were mean absolute error, dynamic time warping, and top extreme events error. We demonstrated that a machine learning approach (convolution neural network, CNN) trained on climate variability indices can model the river runoff better than the long-term monthly mean baseline, both in univariate (per-cell) and multivariate (multi-cell, regionalized) settings. We compared the models to the baseline in the form of heatmaps and presented results of ablation experiments (test time ablation, i.e., jackknifing, and training time ablation), which suggested that ENSO is the primary determinant among the considered indices.
Effects of Ferrihydrite-Impregnated Powdered Activated Carbon on Phosphate Removal and Biofouling of Ultrafiltration Membrane
Authors: Lohwacharin Jenyuk , Maliwan Thitiwut , Osawa Hideki , Takizawa Satoshi
Published: April 2021

The presence of multiple contaminant species in surface waters makes surface water treatment difficult to accomplish through a single process. Herein, we evaluated the ability of an integrated adsorption/ultrafiltration (UF) membrane filtration system to simultaneously remove phosphates and dissolved organic matter (DOM). When bare powdered activated carbon (PAC) and PAC impregnated with amorphous ferrihydrite (FHPAC) adsorbents were compared, FHPAC showed a greater adsorption rate and capacity for phosphate. FHPAC had a phosphate adsorption capacity of 2.32 mg PO43−/g FHPAC, even when DOM was present as a competing adsorbate. In a lab-scale hybrid FHPAC-UF system (i.e. integrated adsorption by FHPAC with UF membrane filtration), irreversible membrane fouling was ca. three times lower than that in a PAC-UF system. When membrane fouling in the PAC-UF system was described with pore blockage models, we found that the main cause of fouling was bacterial deposition on the membrane surface. CLSM analysis determined that the chemical composition of foulants in the PAC-UF system included higher proportions of proteins, nucleic acids, and alpha-polysaccharides than that in the FHPAC-UF system. Overall, FHPAC’s ability to undergo ligand exchanges with DOM helped to reduce the nutrients and bacteria that cause biofouling to accumulate on the membrane surface.
Engineering Project: The Method to Solve Practical Problems for the Monitoring and Control of Driver-Less Electric Transport Vehicles in the Underground Mines
Authors: Li Shuai , Wang Guojun , Yu Haoxuan , Wang Xinmin
Published: April 2021

With the continuous development of Artificial Intelligence technology and Internet of Things engineering, more and more driver-less vehicles have been developed and put into industrial production. The birth of driver-less vehicles undoubtedly brings new vitality to a large amount of industries, particularly in transportation. For the mining industry, transportation is undoubtedly an extremely important link in the whole production process. If the driver-less vehicles can be applied to the underground mines, it can not only improve the production and transportation capacity of the whole mine but also can reduce the occurrence of many mine safety accidents. ZigBee WSN technology can play a greater role in the narrow environment such as underground mines according to the relevant literature; this concept paper, similar to an engineering project plan, mainly tries to integrate the ZigBee WSN technology and the communication-based train control (CBTC) system to explore the possibility of the driver-less vehicles to be used in the underground mines, which aims to solve practical engineering problems for the engineering projects. As the mining engineers, we put forward the concept of this integrated system in this concept paper, but we need to continue to work hard for the future of the underground mines. This concept paper serves as a guide to Tossing out a brick to get a jade gem, and it has a few implications for the development of underground mine transportation.
Identification and restoration of unused agricultural land based on planned land inventory
Authors: Cherkashina E. V. , Sorokina O. A. , Fomkin I. V. , Fedorinov A. V. , Petrova L. E.
Published: April 2021

The article considers the procedure for identification of unused agricultural land for its involvement in economic turnover. The object of study is the Yaroslavl and Smolensk regions of the Russian Federation, where the share of unused agricultural land is from 12 to 50%. This identification is based on the methods of planned land inventory, the main purpose of which is to assess the reasons for land disposal, the cultural and technical conditions of land and preparation of recommendations for introduction of lands into agricultural circulation. This work includes the proposals to establish the order of involvement of land plots into economic turnover.
Actual tasks of land market monitoring
Authors: Bryzhko V. G. , Bryzhko I. V.
Published: April 2021

The article deals with the actual tasks of land market monitoring. The author substantiates the necessity of monitoring of market processes in land use, proposes the defi nition of land market monitoring and the algorithm of its implementation, and also demonstrates the possible ways of using of land market monitoring data.
Stages of land price formation in the urban district of Ufa in the Republic of Bashkortostan
Authors: Suleimanova A. V.
Published: April 2021

The article is about the pricing principles of land in the urban district of Ufa city in the Republic of Bashkortostan. The price changes, by the author, due to underdevelopment of the land market in the conditions of market economy.
Land and resource potential and land use in agrarian sphere of Krasnodar region
Authors: Khakhuk B. A. , Novoselov A. V. , Kolesnikov V. I.
Published: April 2021

The article contains an assessment of the land resource potential, as well as the analysis of use of agricultural land by enterprises of various organizational and legal forms in the Krasnodar Territory.
Prospects for development of the labor market of cadastral engineers in the Russian Federation
Authors: Osenniaya A. V. , Pastuhov M. A.
Published: April 2021

The main purpose of the article is to analyze the labor market of cadastral engineers in the Russian Federation, and determine its prospects for development. To do this, we analyze the number of cadastral engineers from the moment of legislative consolidation of their professional activities, that is, from the moment of the adoption of Federal law No 221.
The influence of taxpayers on the results of the state cadastral evaluation in accordance with the new rules
Authors: Borodina O. , Zhdanova R.V.
Published: April 2021

This article describes the ways of participation of interested persons during the state cadastral evaluation by providing comments and additional information about the objects of assessment.
Planning and monitoring the condition and use regime of the water-protected zone of the Belgorod reservoir using unmanned aerial vehicles
Authors: Savelieva A. E.
Published: April 2021

The author pays a particular attention to solving the problems of monitoring the water protection zone of the Belgorod reservoir, especially the status and regime of use of water protection zones and changes in the morphometric features of water bodies or their parts and their water protection zones using UAVs. UAVs are considered depending on the design. The author made a conclusion about the necessary type of UAV for monitoring the condition of the coast and water protection zones of the Belgorod reservoir. The main technical characteristics of the recommended aircraft UAVs are presented in this paper as well.
THE IMPORTANCE OF ARTICSIC DETAIL AS A FACTOR OF PROSE POETICALNESS IN THE SGORT STORIES OF THE CONTEMPORARY AMERICAN AND CANADIAN WRITERS
Authors: YEMETS O. , ZAKHARCHUK A.
Published: April 2021

The article considers the role and functions of artistic detail in the contemporary short stories. The investigation involved the flash fiction stories by the American writers written after the year 2020 and several short stories by the outstanding Canadian writer Alice Munro. The aim of the research is determining the major devices of prose poeticalness in these texts and revealing the role of artistic detail in creating poeticalness.Prose poeticalness is defined as such property of a prose text which involves the priority of poetic function and envisages the introduction of poetical features into prose – stylistic convergence, phonetical repetitions, parallelism, rhythm. Stylistic convergence can be considered the most foregrounded device of poeticalness as it involves the accumulation of different stylistic devices which add expressiveness to each other (M.Riffaterre). Our investigation shows that convergences function in strong positions of texts- the initial or final text fragments. Artistic detail is the object or some feature of the object which acquires special importance in the literary text (V.A.Kukharenko). Artistic detail is usually associated with metonymy or synecdoche, but unlike these tropes, it embraces the whole text. In the flash fiction stories and the short stories by A.Munro the major artistic details are objects like a coin (L.Wilson), a brooch (A.Munro), a glove (D.Shea) or a feature of appearance like a bruise (S.Dybek). These details characterize people’s behavior, their dreams and aspirations. Therefore, they symbolize love, friendship, sympathy and give polysemantic character to the narration. Another result of our investigation is determining the metaphoric detail (G.Paley) in the description of the woman, the mother of the defendant. Thus, the emotional effect of the artistic detail is realized in the metaphoric similes comparing the woman to the faded flower. These artistic details in combination with stylistic convergence create the impression of the texts as modern parables. The theoretical novelty of our research lies in the analysis of artistic details from the viewpoint of poeticalnees as well as in revealing the significance of emotional effect for prose poeticalness.The prospects of further research lie in the investigation of poeticalness in other genres of modern prose.
THE PROBLEM OF THE CORRELATION BETWEEN SPIRIT AND REALITY IN T. MANN’S NOVEL “TRISTAN”
Authors: KONIEVA T.
Published: April 2021

Short stories are an integral part of T. Mann’s creative heritage, which are distinguished by ideological, thematic and artistic richness, they give an idea of the evolution of the creative method and style of the writer. And although nowadays there is already a number of scientific investigations devoted to the review analysis of T. Mann’s creative path, there is a need to study the problem of culture “end of time” (in T. Mann’s terminology) in the novelistic work of the writer who went to political and social activities through art. The purpose of the article is to reveal the nuances of the relationship between spirit and reality in T. Mann’s short story “Tristan”.The article proves that within the cross-cutting problem of the relationship between art and life, which never ceased to bother the German writer, also the novel “Tristan” clearly distinguishes the related ones: art and beauty, art and morality, aesthetics and life, beauty and death, decadence and a disease of the spirit, the artist and reality, which allowed to clarify both the ideological concepts of creative individuality and the essence of its art. At the same time, the divergence between the views of the hero of the novel and T. Mann’s personal attitude to reality and art is shown. Enough attention is paid to identifying the role of the comic and the means of its formation in the novel. “Tristan” is interpreted in the context of the development of T. Mann’s work and the European literary process at the turn of the XIX - early XX centuries.The article identifies the place of the short story “Tristan” in the work of the German master of the word and outlines the ways of its further analysis.
THE KOCHUBEY FTMELY AS LITERARY HEROES
Authors: ORLOVA O.
Published: April 2021

The Kochubey family has left a significant mark on history, politics, and state reform. The article considers the representatives of the family as statesmen and literary characters of the works of Alexander Pushkin and Leo Tolstoy. Vasyl Kochubey, the protagonist of the poem “Poltava”, provokes discussions about Pushkin’s assessments of the events of the Great Northern War. However, the author of the poem was interested primarily in the psychological aspect of the character of a person who was captivated by parental feelings. The romanticized image of Kochubey is similar to the image of Mazepa from Byron’s poem, also far from historical similarity. L. Tolstoy’s novel depicts another well-known representative of the family, Viktor Pavlovich Kochubey, whose role in the work is significant not in the plot development, but ideologically - as an alternative to the Decembrist path of development of the Russian Empire. This is the hero who influenced the principles of Andrew Balkonsky, partially influenced the views of his son. The article suggests the absence of images of Dykan Kochubeys in the works of M. Gogol. The theme of historical and literary memory in the works of M. Gogol, who bypassed the silence of famous neighbors, is studied. The Kochubey family left a noticeable mark on Poltava land. Dykanka is still called Kochubeyivska, there is the Mykolayiv Church with a family crypt and an oak alley, which witnessed the love of Mazepa and Motri.
Dede Korkut Kitabı Türkistan/Türkmen Sahra Nüshasında Yer Alan İslami Unsurların Din ve Toplum İlişkisi Bağlamında Değerlendirilmesi
Authors: DEMİRCAN Tuğba
Published: April 2021

İnsan, sosyal bir varlık olması sebebiyle toplumsal bir yaşama gereksinim duyar. Din, insanın ihtiyaç duyduğu toplumsal yaşamın en önemli belirleyicilerinden biridir. İslamiyet, inanç esasları ve başlıca ahlak prensipleri ile içtimaı bir yapı ortaya koymaktadır. Türkler, tek Tanrı inancına ve sahip oldukları ahlak düzenine uygun düşmesi nedeniyle kendi istek ve iradeleriyle İslam dinini kabul etmişlerdir. Dede Korkut Kitabı’nda, eski Türk inanç sisteminin yanı sıra İslam dinine dair ayrıntılı bilgiler izlemek mümkündür. Türkistan/Türkmen Sahra Nüshası bu anlamda dikkate değer bir içeriğe sahiptir. Çalışmada, nüshada yer alan İslami unsurların din ve toplum ilişkisi bağlamında nasıl bir görünüm arz ettiklerinin ortaya çıkarılması amaçlanmıştır. Bu doğrultuda, Türkistan/Türkmen Sahra Nüshası, dinin temel yapısında bulunan inanç, ibadet ve ahlak esasları çerçevesinde yorumlanmıştır. Bu aşamada, Dede Korkut Kitabı’nın bir bütün olduğu düşüncesinden hareketle diğer boylara dair örneklerden de faydalanılmıştır. Nüshada yer alan İslami unsurlardan hareketle yapılan incelemeler, İslamiyet’e geçiş sürecinin toplumsal yorumunu ortaya çıkarmıştır.
The use of various technologies in the surgical treatment of decompensated forms of varicose veins of the lower extremities with unilateral valvular incompetence of the great saphenous and anterior accessory saphenous vein
Authors: Sokolov O. V.
Published: April 2021

Purpose of the study. Comparative evaluation of the results of treatment of patients with varicose veins (VVs) in stage C6, with the valve incompetence of the trunks of GSV and ASSV in one lower limb, by traditional venectomy and radiofrequency ablation (RFA).

Materials and methods. The study was conducted on the basis of MI «RCH n.a. І.І. Mechnikov», MNE «CCH №16» DCC and MC «JMC Menorah» from 2010 to 2020 yy. Included 43 patients: women – 29 (67,4%), men – 14 (32,6%). Age – from 29 to 74 years (average – 52,7 ± 10,8 years). Patients are divided into 2 groups. The I group (n = 22) included patients who underwent traditional venectomy of GSV and ASSV, the II group (n = 21) – patients who underwent RFA under local anestesia. The observation lasted 12 months.

Results. The average area of ulcers ranged from 1 to 12 cm2. The average area of ulcers in group I was 6,3 ± 3,1 cm2, in group II – 6,2 ± 2,7 cm2. Complete epithelialization of ulcers occurred faster with the use of RFA (group II) – 38,1 ± 5,7 days against 44,7 ± 6,2 days in group I. After 3 months. the number of healed ulcers in group I. was 20 (83,3%), in II – 24 (96,0%). Ulcer recurrence one year after surgery occurred in 4 (5,6%) patients of group I, in group II there were no recurrences. After 6 months the difference between the severity of CVI (VSS) was 10,5 ± 2,8 points in group I and 13,9 ± 2,2 points in group II.

Conclusions. 1. Surgical treatment of VVs at unilateral defeat of GSV and ASSV with use of RFA differs in the better profile of a postoperative pain syndrome, less traumatism, has the best indicators of recovery in comparison with a traditional venectomy. 2. Treatment with RFA in comparison with traditional phlebectomy one year after surgery had an advantage in the number of recurrences of trophic ulcers
Use of the developed bone holder for open reposition of small tubular bones
Authors: Moskalkov A. P. , Markov P. K. , Pereligin I. N.
Published: April 2021

The disadvantages and traumatic injury of using traditional traumatological instrumentation for open reduction of metacarpal fractures prompted the development of a modified bone holder. The clinical experience of using the developed instrument is presented, the advantages of its use are displayed.
Practically important clinical characteristics of the modern silantev to seal the teeth of children
Authors: Matchenko K. S.
Published: April 2021

Annotation. Incomplete posteruptive maturation of the chewing group of teeth in children, along with increased availability of carbohydrate food, deterioration of the ecology and composition of drinking water, as well as features of the morphology of fissure, cause increased susceptibility of occlusal surfaces to caries. It is argued that one of the key methods of preventing caries of the chewing surface of the teeth in children is the sealing of fissures, which is based on modern principles of evidence-based medicine. The advantages of sealing over the use of fluorinated lacquers are analyzed, modern groups of silants are investigated and their practically significant clinical characteristics are revealed.
COMPARATIVE ANALYSIS OF PROGRAM SUBJECT AREAS FOR TRAINING INFORMATION TECHNOLOGY MANAGERS IN UKRAINE AND THE UNITED STATES
Authors: Горетько Тетяна
Published: April 2021

The article presents a comparative analysis of information technology and management subject areas in Ukraine and the US over the past 25 years. Special attention is given to the program subject areas under which universities can train specialists in IT management, a branch at the intersection of IT and management. In particular, the article traces transformations in the Cabinet of Ministers’ decrees on these fields of study, and details the amendments introduced into the classification of qualification levels, fields of study and subject areas in compliance with Decrees № 325 dated 1994, № 507 dated 1997, № 1719 dated 13.12.2006, № 787 dated 27.08.2010, and № 266 dated 2015. The article also outlines the higher education standards on IT and management developed on the basis of active Decree № 266 and other regulations. Further, it identifies the specifics of professional training of managers and IT specialists in the US. In particular, it outlines the Guiding Principles and Standards for Business Accreditation by the Association to Advance Collegiate Schools of Business, and the Computing Curricula Guidelines jointly developed by the Association for Computing Machinery and the Computer Society of the Institute for Electrical and Electronic Engineers. Finally, the article correlates computing-related study areas in Ukraine and the US, and shows that reforms in IT and management fields of study are still in progress in Ukraine. The author concludes that while IT components in management subject areas are quite comparable in Ukraine and the US, the weight of business ones in IT subject areas is much smaller in Ukraine, which sidelines the professional training of IT managers in these subject areas. The author stresses the prospects of further analysis of the IT management programs available in Ukraine as well as the opportunities of incorporating the US experience to develop professional training of IT managers in the universities of Ukraine.

Key words: program subject area; field of study; higher education standards; information technology; management; IT managers.
СИСТЕМА ОСВІТИ ДОРОСЛИХ У ТУРЕЦЬКІЙ РЕСПУБЛІЦІ
Authors: Постригач Надія
Published: April 2021

Автором оглядової статті проаналізовано особливості організації системи освіти дорослих у Турецькій Республіці; виокремлено конструктивні педагогічні ідеї можливого запозичення турецького досвіду у теорію і практику вітчизняної неперервної освіти. З’ясовано, що навчання дорослих є найрізноманітнішим із секторів навчання впродовж усього життя, а національні системи навчання дорослих є складними та неоднорідними. Доведено, що інституційні спроби Туреччини були спрямовані на підтримку та поширення освіти дорослих і сприяли полегшенню доступу до освітніх джерел і матеріалів, упровадження освіти дорослих через навчання впродовж життя. Результатом спроб вдосконалити сектор навчання дорослих було створення при університетах Центрів безперервної освіти, що забезпечують освітні можливості та задоволення потреб як дорослих, так і різних секторів економіки. Обґрунтовано необхідність підвищення кваліфікації спеціалістів упродовж тривалих періодів, а також встановлення більш налагоджених зв'язків між Центрами професійної освіти та бізнесом. Визначено ключових постачальників освітніх послуг, основні установи та джерела фінансування освіти дорослих; проаналізовано нормативно-правове забезпечення організації та розвитку системи освіти дорослих у Турецькій республіці. З’ясовано, що у Туреччині з метою поширення та розвитку освіти дорослих зреалізовано проєкти Світового банку та ЄС, проєкти у сфері грамотності дорослих, громадянської та професійно-технічної освіти, укладено численні угоди про співпрацю тощо. Доведено, що завдяки проєктам ЄС збільшуються можливості для мобільності та партнерства, а також навчання дорослих, розвитку вищої освіти, професійної підготовки студентів, вчителів, тренерів, молодіжних працівників та інших категорій дорослих.

Ключові слова: навчання упродовж життя; організація системи освіти дорослих; навчання дорослих; професійна освіта і навчання; Турецька Республіка.
НАУКОВО-ПРАКТИЧНІ ЗАХОДИ У СФЕРІ ОСВІТИ ДОРОСЛИХ – 2020
Authors: Лук'янова Лариса , Аніщенко Олена , Котун Кирил
Published: April 2021

У публікації систематизовано науково-практичні заходи у сфері освіти дорослих, організовані й проведені у 2020 році за ініціативи та співініціативи науковців відділу андрагогіки Інституту педагогічної освіти і освіти дорослих імені Івана Зязюна НАПН України. Заходи є складовою просвітницької діяльності Інституту, спрямованої на сприяння особистісному й професійному розвитку різних категорій дорослих, плекання культури навчання впродовж життя, популяризацію результатів фундаментальних і прикладних наукових досліджень у сфері формальної, неформальної та інформальної освіти дорослих.
ПОЛІТИЧНІ ВЕКТОРИ ЮНЕСКО В РОЗВИТКУ ОСВІТИ ДОРОСЛИХ
Authors: Авшенюк Наталія
Published: April 2021

В оглядовій статті на підставі інтегрованого аналізу ключових документів ЮНЕСКО (Рекомендацій Міжнародних конференції з освіти дорослих CONFINTEA (1985 р., 1997 р., 2003 р., 2009 р.), Глобальних звітів з освіти дорослих (2009 р., 2013 р., 2016 р., 2019 р.)) окреслено вплив доказових досліджень освітньої політики вобґрунтуванні напрямів розвитку освітньої політики в галузі навчання й освіти дорослих у світовому освітньому просторі наприкінці ХХ – початку ХХІ ст. Встановлено, що у визначеному періоді необхідність розвитку освіти дорослих обумовлена динамікою соціального і науково-технічного прогресу; змінами в змісті й характері праці й суспільної діяльності людей; збільшенням вільного часу і можливостей його раціонального використання; запитами ринку праці, головними вимогами, якого стають підвищення компетентності й професіоналізму фахівця. Залучення дорослої людини до різних форм освітньої діяльності впродовж життя сприяє не лише задоволенню власних потреб, а й самореалізації у вільному виборі місця, часу, траєкторії удосконалення. Доведено, що з 70-х рр. в ХХ ст. й донині ЮНЕСКО відіграє ключову роль у формулюванні та дисемінації в сфері освітньої політики концепції навчання впродовж життя. Концепція, по суті, передбачає реструктуризацію існуючої системи освіти та використання освітнього потенціалу навчання дорослих поза традиційною освітньою системою з метою впливу на розвиток різних соціальних груп та індивідуальний розвиток кожної людини. У світі накопичено значний конструктивний досвід розвитку теорії і практики освіти дорослих, який акумулюється, поширюється й впроваджується завдяки діяльності міжнародних організацій глобального масштабу, зокрема ЮНЕСКО. Ця міжнародна організація генерує ідеї й вибудовує освітню політику, що ґрунтується на надійних статистичних даних і результатах глобальних емпіричних досліджень.

Ключові слова: безперервна освіта впродовж життя, освіта дорослих, міжнародна освітня політика, критична педагогіка, ЮНЕСКО, Міжнародна конференція з освіти дорослих CONFINTEA