bluuebunny/crossref_metadata_2025 huggingface dataset:
Factors Determining the Development of Prosumer Photovoltaic Installations in Poland
Authors: Wicki Ludwik , Pietrzykowski Robert , Kusz Dariusz
Published: August 2022

The development of energy production from renewable sources includes the production of energy from photovoltaic installations by prosumers. In Europe, RES development is driven by political goals and requires subsidies during the deployment period, at least as long as the cost of renewable electricity does not reaches grid parity. The study attempts to determine the importance of factors in the development of energy production by prosumers from PV installations in Polish regions. In 2019, the ‘Moj Prad’ program was introduced, applying subsidies to investment costs and the settlement of energy production in the net-metering system. Almost 900 thousand prosumer PV installations were built by the end of 2021, with a total capacity of 5.9 GW. Solar energy share grew from 0.1 to 2.1%. Spatial econometrics models were use in research to determine factors of prosumer PV systems development in Poland (at NUTS-2). Spatial regimes were found in the studied regions, as indicated by a positive autocorrelation (0.75). Considering the pseudo-R-square co-efficient, we can conclude that the spatial error, i.e., factors not included in the GNS model, constitutes approximately 10%. The economic variables included in the Mansky model, i.e., level of salaries and GDP, explain 90% of the variability of installed PV capacity (Nagelkerke pseudo-R-squared value is 0.906). The level of development of prosumer photovoltaic installations (in W per capita) in regions depends primarily on economic factors represented by the level of salaries in a given region. With the increase in salaries by one unit, we also have an increase in installed power capacity in watts per person by 3.52. Surprisingly, the region’s overall wealth did not matter, as the relative number of installations in regions with lower GDP was higher than in others. One can explain that the individual income of households is more important for increasing the number of prosumer installations than the income of the regional economy. The increase in the number of installations in one region contributed to the subsequent increase in their number in neighboring regions.
Effects of High Hydrostatic Pressure on Fungal Spores and Plant Bioactive Compounds
Authors: Pinto Carlos A. , Holovicova Maria , Habanova Marta , Lima Vasco , Duarte Ricardo V. , Barba Francisco J. , Saraiva Jorge A.
Published: August 2022

Fungi, and their spores, are responsible for the spoilage of several foods and plants and are susceptible to contamination with mycotoxins, which have associated health hazards. In this context, proper methodologies for inactivating such fungi and controlling mycotoxin production are critical. High-pressure processing (HPP) has recently become popular as a nonthermal alternative to conventional thermal pasteurization processes. Even though HPP can effectively eliminate some fungal spores, some species, such as those from the genera Byssochlamys, Talaromyces, and Aspergillus, are quite resistant to this treatment. Additionally, high pressure can also be used as a cold extraction technique for bioactive compounds from medicinal plants and other matrices (termed high pressure-assisted extraction, HPE). With this method, safe use for food, cosmetic, and pharmaceutical applications is guaranteed. This method simultaneously works (depending on the applied pressure level) as an extraction technique and induces the pasteurization effect on the extracts. This encyclopedia entry aims to highlight the effects of nonthermal HPP on fungal spores, the prevalence of mycotoxins in plant materials and how high pressure can be used as an extraction technique to produce high-value cold pasteurized extracts with biological activity.
Duration of Climate Change Mitigation Benefits from Increasing Boreal Forest Harvest Age by 10 Years
Authors: Ter-Mikaelian Michael T. , Chen Jiaxin , Colombo Stephen J.
Published: August 2022

We presented a case study and associated method for stand scale assessment of the duration of the climate change mitigation benefit provided by increasing forest harvest age (i.e., the age a stand is harvested). We used stand yield curves and newly developed equations to estimate carbon stocks in various boreal forest ecosystem pools in Ontario, Canada. The proposed method was applied to forest identified as available for harvesting in management plans for three forest management units with a combined area of more than 1900 km2. Our analysis indicated that a 10-year increase in harvest age did not provide a mitigation benefit (reduced carbon stock) in about half the available harvest area (45.5%, 61.9%, and 62.1% of the total available harvest area in the management units). Increasing the harvest age by 10 years resulted in a mitigation benefit lasting longer than 25 years for 15.1%, 16.0%, and 13.0% of the total available harvest area in the management units. The results suggest that increasing harvest age may have limited mitigation potential in Ontario’s managed boreal forests in the short-term but can reduce overall carbon stocks in the longer term.
Kadsura longipedunculata Finet & Gagnepain (Schisandraceae): An Overview of Botany, Traditional Uses, Phytochemistry and Pharmacological Activities
Authors: Idrees Muhammad , Zhang Zhiyong , Yaseen Aftab , Jiao Yongqing , Zheng Xu
Published: August 2022

Kadsura longipedunculata Finet & Gagnepain (Chinese Kadsura vine) is an evergreen climbing shrub that is widely found in the southwest province of China. The plant can be used as folk medicine to cure canker sores, dysmenorrhea, traumatic injury, insomnia, rheumatoid arthritis, gastrointestinal inflammation, menstrual disorders, and feminine condition. We conducted an open-ended, online database search with the help of Baidu Scholar, CNKI, Elsevier, Scopus, ScienceDirect, Google, Pubmed, and Web of Science for all publications accessible from 1986 to 2022, using the terms related to traditional uses, botany, phytochemistry, and pharmacological properties. A total of ca. 314 phytochemicals were reviewed and identified in K. longipedunculata, with lignans and terpenoids as the predominant groups. The isolated compounds of this plant possess cytotoxic, antioxidant, antitumor, anti-inflammatory, anti-insomnia, anti-trypanosomal, anti-platelet aggregation, hepatoprotective, and other pharmacological effects. This review offers primary data for further research needed to determine the chemical components responsible for its pharmacological effect in order to continue its traditional use. More clinical and preclinical evidence is required to determine the rationale and safety of using K. longipendunculata for medicinal and food purposes.
Effects of Exogenous Antioxidant Melatonin on Physiological and Biochemical Characteristics of Populus cathayana × canadansis ‘Xin Lin 1’ under Salt and Alkaline Stress
Authors: Song Runxian , Ritonga Faujiah Nurhasanah , Yu Haiyang , Ding Changjun , Zhao Xiyang
Published: August 2022

Salt and alkaline stress is one of the important problems restricting agricultural production and afforestation projects. This kind of stress will greatly limit the growth and development of forest trees. Recently, melatonin has been gradually realized as a strong kind of antioxidant due to its important regulatory and protective roles in the process of plant growth and development. This study takes Xin Lin 1 (Populus cathayana × canadansis ‘Xin Lin 1’) as the research object, and measures the changes of physiological indexes at different time points to verify the alleviation effect of melatonin under salt and alkaline stress. In this experiment, plants have different behaviors in the face of different levels of exogenous melatonin. Among them, low concentrations of melatonin (50 μM and 100 μM) were more helpful to reduce the levels of MDA and osmotic regulators in leaves. At this level, the SOD and CAT content in the leaves increased significantly. Melatonin at 800 μM was more inclined to induce POD, but its activity was not significantly induced. Overall, melatonin contributes to the secretion of ABA in plants and has a tendency to inhibit the content of SA. It is worth mentioning that the 100 μM melatonin treatment was more conducive to the secretion of IAA. To sum up, this experiment proves that melatonin has a dose effect in alleviating stress.
Enhancing Height Predictions of Brazilian Pine for Mixed, Uneven-Aged Forests Using Artificial Neural Networks
Authors: Costa Emanuel Arnoni , Hess André Felipe , Finger César Augusto Guimarães , Schons Cristine Tagliapietra , Klein Danieli Regina , Barbosa Lorena Oliveira , Borsoi Geedre Adriano , Liesenberg Veraldo , Bispo Polyanna da Conceição
Published: August 2022

Artificial intelligence (AI) seeks to simulate the human ability to reason, make decisions, and solve problems. Several AI methodologies have been introduced in forestry to reduce costs and increase accuracy in estimates. We evaluate the performance of Artificial Neural Networks (ANN) in estimating the heights of Araucaria angustifolia (Bertol.) Kuntze (Brazilian pine) trees. The trees are growing in Uneven-aged Mixed Forests (UMF) in southern Brazil and are under different levels of competition. The dataset was divided into training and validation sets. Multi-layer Perceptron (MLP) networks were trained under different Data Normalization (DN) procedures, Neurons in the Hidden Layer (NHL), and Activation Functions (AF). The continuous input variables were diameter at breast height (DBH) and height at the base of the crown (HCB). As a categorical input variable, we consider the sociological position of the trees (dominant–SP1 = 1; codominant–SP2 = 2; and dominated–SP3 = 3), and the continuous output variable was the height (h). In the hidden layer, the number of neurons varied from 3 to 9. Results show that there is no influence of DN in the ANN accuracy. However, the increase in NHL above a certain level caused the model’s over-fitting. In this regard, around 6 neurons stood out, combined with logistic sigmoid AF in the intermediate layer and identity AF in the output layer. Considering the best selected network, the following values of statistical criteria were obtained for the training dataset (R2 = 0.84; RMSE = 1.36 m, and MAPE = 6.29) and for the validation dataset (R2 = 0.80; RMSE = 1.49 m, and MAPE = 6.53). The possibility of using categorical and numerical variables in the same modeling has been motivating the use of AI techniques in different forestry applications. The ANN presented generalization and consistency regarding biological realism. Therefore, we recommend caution when determining DN, amount of NHL, and using AF during modeling. We argue that such techniques show great potential for forest management procedures and are suggested in other similar environments.
TinoTranscriptDB: A Database of Transcripts and Microsatellite Markers of Tinospora cordifolia, an Important Medicinal Plant
Authors: Singh Rakesh , Mahato Ajay Kumar , Singh Akshay , Kumar Rajesh , Singh Amit K. , Kumar Sundeep , Marla Soma S. , Kumar Ashok , Singh Nagendra K.
Published: August 2022

Tinospora cordifolia, commonly known as “Giloe” in India, is a shrub belonging to the family Menispermaceae. It is an important medicinal plant known for its antipyretic, anti-inflammatory, antispasmodic, and antidiabetic properties and is used in the treatment of jaundice, gout, and rheumatism. Despite its economic importance, the limited information related to its genomic resources prohibits its judicious exploitation through molecular breeding or biotechnological approaches. In this study, we generated a meta-transcriptome assembly of 43,090 non-redundant transcripts by merging the RNASeq data obtained from Roche 454 GS-FLX, and Illumina platforms, and report the first transcriptome-based database for simple sequence repeats and transcription factors (“TinoTranscriptDB” (Tinospora cordifolia Transcriptome Database)). We annotated 26,716 (62%) of the total transcripts successfully from National Center for Biotechnology Information non-redundant protein (NCBI-NR), gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Swiss-Prot, and Pfam databases. This database contains information of 2620 perfect simple sequence repeats (P-SSRs) with a relative abundance of 340.12 (loci/Mb), and relative density of 6309.29 (bp/Mb). Excluding mono-nucleotides, the most abundant SSR motifs were tri-nucleotides (54.31%), followed by di-nucleotides (37.51%), tetra-nucleotides (4.54%), penta-nucleotides (3.16%) and hexa-nucleotides (0.45%). Additionally, we also identified 4,311 transcription factors (TFs) and categorized them into 55 sub-families. This database is expected to fill the gap in genomic resource availability in T. cordifolia and thus accelerate molecular breeding and related functional and other applied studies aimed towards genetic improvements of T. cordifolia and related species.
Interactome of PTH-Regulated miRNAs and Their Predicted Target Genes for Investigating the Epigenetic Effects of PTH (1–34) in Bone Metabolism
Authors: Vrščaj Lucija Ana , Marc Janja , Ostanek Barbara
Published: August 2022

Osteoporosis is a metabolic bone disease that mostly affects the elderly. A lot of drugs are available, mostly with an antiresorptive effect but just a few with an osteoanabolic effect, meaning they promote bone building. PTH (1-34) or teriparatide is an osteoanabolic drug, but its efficacy varies between individuals. We performed a literature review and extracted a dataset of 62 microRNAs (miRNAs) from 10 different studies; predicted miRNA target interactions (MTIs) were obtained with the help of four software tools: DIANA, miRWalk, miRDB and TargetScan. With the construction of an interactome of PTH-regulated miRNAs and their predicted target genes, we elucidated miR-146a-5p, miR-551b-5p, miR-205-3p, miR-33a-3p, miR-338-5p as miRNAs with the most interactions and miR-410-3p as the miRNA targeting bone-related pathways with the highest significance. These miRNAs could help in further understanding the mechanism of action of PTH on bone metabolism and osteoporosis. They also have the potential for novel network-based biomarkers for osteoporosis treatment efficacy and safety and as new therapeutic targets.
An Analysis of Phenotype and Genotype in a Large Cohort of Chinese Children with Angelman Syndrome
Authors: Du Xiaonan , Wang Ji , Li Shuang , Ma Yu , Wang Tianqi , Wu Bingbing , Zhou Yuanfeng , Yu Lifei , Wang Yi
Published: August 2022

Angelman syndrome (AS) is a neurodevelopmental genetic disorder, but there has been limited analysis of a large cohort of Chinese children with Angelman syndrome. This study aims to assess the phenotype and genotype of Chinese children with Angelman syndrome. We retrospectively analyzed data through a detailed online survey combined with an on-site study. Furthermore, phenotype analysis stratified by deletion and non-deletion groups was carried out. The responses of family members of 695 individuals with AS revealed that 577 patients (83.02%) had maternal deletions, 65 patients (9.35%) carried UBE3A mutations, 31 (4.46%) patients had UPD15pat (one patient with UPD15pat constituted by a mosaic), 10 patients (1.44%) had imprinting defects and 12 (1.58%) patients only showed abnormal methylation without further detection. We identified 50 different pathogenic variants in this cohort, although 18 of these variants were unreported. Recurrent variant c.2507_2510del (p.K836Rfs*4) was found in 7 patients. In the deletion group, patients were diagnosed at an earlier age, had a more severe clinical phenotype, a higher rate of epilepsy with more multiple seizure types, and more frequently combined medication. Strabismus and sleep disturbances were both common in deletion and non-deletion groups. The top three resources invested in caring for AS children are: daily involvement in patient care, rehabilitation cost, and anti-epileptic treatment. Our study showed the genetic composition of Chinese children with 83.02% of maternal deletions, and the mutation spectrum for UBE3A variants was expanded. Developmental outcomes are associated with genotype, and this was confirmed by deletion patients having a worse clinical phenotype and complex epilepsy.
Is Working from Home during COVID-19 Associated with Increased Sports Participation? Contexts of Sports, Sports Location and Socioeconomic Inequality
Authors: Grubben Malou , Wiertsema Sara , Hoekman Remco , Kraaykamp Gerbert
Published: August 2022

Previous research has focused mainly on the association between working from home (WFH) and physical activity, establishing that physical activity diminished among people WFH during the COVID-19 pandemic. In our study, we investigated the association between WFH and specifically sports participation (competitive and non-competitive). We theorized that WFH would offer individuals additional opportunities to practice sports during the pandemic. Governmental restrictions at the time constrained opportunities to participate in organized sports and in sports with others. We, therefore, expected sports participation during the pandemic to be largely restricted to individual participation and participation at home or in the public space. By means of descriptive analyses and adjusted analyses of variance (n = 1506), we found positive associations between WFH and various aspects of sports participation. Lower-educated individuals, in particular, seem to be benefiting from WFH related to their sports participation in the public space, and economically deprived individuals also seem to be benefiting from WFH in regard to their sports participation at home. Our findings extend the literature on physical activity and sports participation among people who worked from home during the COVID-19 pandemic while offering implications for policies on WFH, sports opportunities in public space and physical activity-friendly environments.
Experienced Effects on Well-Being following Smoking Cessation: Findings from the 2020 ITC Four Country Smoking and Vaping Survey
Authors: Li Lin , Borland Ron , Yong Hua-Hie , Gravely Shannon , Fong Geoffrey T. , Cummings Kenneth Michael , East Katherine , Le Grande Michael
Published: August 2022

Background and Aims: There has been limited research addressing changes in subjective well-being as a result of quitting smoking. This paper examines recent ex-smokers’ well-being related experiences overall and as a function of (1) duration of cessation and (2) continued nicotine use from vaping. Methods: A sample of 1379 ever-daily smoking ex-smokers (quit for up to 5 years) from the 2020 ITC Four Country Smoking and Vaping Survey (Australia, Canada, the UK, and the US), of which 27.1% currently vaped daily. Well-being measures were perceived changes post-quitting in emotion coping (stress and negative emotions), enjoyment of life, and day-to-day functioning. We also assessed the level of persisting worry about past smoking leading to future health problems. Results: Overall, among those answering all four well-being measures, 51.8% of the ex-smokers reported positive effects and no negatives, but 27.3% reported at least one negative effect, with the remainder reporting no change in any measure. Positive effects were greater among those who had quit more than 1 year prior. The largest improvement (56.3%) was for daily functioning, which showed improvement over time since having quit. Current daily vapers reported similar well-being as those not vaping; however, fewer daily vapers reported worsening ability to cope with stress (10.2% vs. 20.7%). Overall, 84% reported being worried about future negative health effects of smoking, with no clear differences by quitting duration or vaping status. Conclusions: Most ex-smokers reported changes in their well-being since quitting, with more reporting improvements than declines. Well-being improved with duration of time since quitting, but did not appear to be influenced by daily vaping use, but stress coping may be better among vapers. Persisting worries about possible future health effects from smoking may be reducing the experienced benefits of quitting smoking for some.
Design and Validation of a New Tennis-Specific Reactive Agility Test—A Pilot Study
Authors: Munivrana Goran , Jelaska Igor , Tomljanović Mario
Published: August 2022

Agility is an important ability for tennis players, but there is an evident lack of studies focusing on the applicability of tennis-specific agility tests that capture a combination of the physical and cognitive agility performance. Therefore, the main aim of this study was to design and test measurement properties of the tennis-specific reactive agility test that would be feasible and practical for regular implementation. A total of 32 youth tennis players (21 males and 11 females; 10.85 ± 1.50 years) participated in this study. The measurement characteristics of the newly designed reactive agility tennis-specific (TS-RAN) test have been established by comparing it with two generic agility tests and with two tennis-specific pre-planned agility tests. The overall reliability of the new TS-RAN test can only be considered “moderate to good”, as although the results of participants showed good internal consistency, the within-subject reliability of the test proved to be unsatisfactory, since the participants showed a lack of performance consistency. This is not unexpected considering the very young age of the participants who performed the test for the very first time. The new TS-RAN test was highly projected (0.91) on the same single latent dimension, with the variance predominately explained by the tennis-specific agility tests. The test’s greatest strength is its high feasibility, since the test does not require any special set-up nor technical equipment, and that makes it practical for regular implementation in a practical setting. Further research studies are needed in order to confirm the test’s potential to be widely accepted and used.
Effectiveness of Microcurrent Therapy for Treating Pressure Ulcers in Older People: A Double-Blind, Controlled, Randomized Clinical Trial
Authors: Avendaño-Coy Juan , Martín-Espinosa Noelia M. , Ladriñán-Maestro Arturo , Gómez-Soriano Julio , Suárez-Miranda María Isabel , López-Muñoz Purificación
Published: August 2022

The aim of this study was to assess the effectiveness of microcurrent therapy for healing pressure ulcers in aged people. A multicentric, randomized clinical trial was designed with a sham stimulation control. The experimental group received an intervention following a standardized protocol for curing ulcers combined with 10 h of microcurrent therapy daily for 25 days. The sham group received the same curing protocol plus a sham microcurrent stimulation. The studied healing-related variables were the Pressure Ulcer Scale for Healing (PUSH) and the surface, depth, grade, and number of ulcers that healed completely. Three evaluations were conducted: pre-intervention (T1), 14 days following the start of the intervention (T2), and 1 day after the intervention was completed (T3). In total, 30 participants met the inclusion criteria (n = 15 in each group). The improvement in the PUSH at T2 and T3 was 16.8% (CI95% 0.5–33.1) and 25.3% (CI95% 7.6–43.0) greater in the experimental group versus the sham control, respectively. The reduction in the wound area at T2 and T3 was 20.1% (CI95% 5.2–35.0) and 28.6% (CI95% 11.9–45.3) greater in the experimental group versus the control, respectively. Microcurrent therapy improves the healing of pressure ulcers in older adults, both quantitatively and qualitatively.
Succession of Microbial Community during the Co-Composting of Food Waste Digestate and Garden Waste
Authors: Wang Xiaohan , He Xiaoli , Liang Jing
Published: August 2022

Microorganisms are of critical importance during the composting process. The aim of this study was to reveal the bacterial and fungal compositions of a composting pile of food waste digestate and garden waste, where the succession of the microbial communities was monitored using Illumina MiSeq sequencing. We explored the efficiency of composting of different microorganisms to judge whether the composting system was running successfully. The results showed that the composting process significantly changed the bacterial and fungal structure. Firmicutes, Proteobacteria, and Bacteroidota were the dominant phyla of the bacterial communities, while Ascomycota was the dominant phylum of the fungal communities. Moreover, the highest bacterial and fungal biodiversity occurred in the thermophilic stage. The physical and chemical properties of the final compost products conformed to the national standards of fertilizers. The efficient composting functional microbes, including Cladosporium, Bacillus and Saccharomonospora, emerged to be an important sign of a successfully operating composting system.
Designing Mobile Epidemic Prevention Medical Stations for the COVID-19 Pandemic and International Medical Aid
Authors: Gao Mi-Zuo , Chou Ying-Hsiang , Chang Yan-Zin , Pai Jar-Yuan , Bair Henry , Pai Sharon , Yu Nai-Chi
Published: August 2022

The demand for mobile epidemic prevention medical stations originated from the rapid spread of the COVID-19 pandemic. In order to reduce the infection risk of medical practitioners and provide flexible medical facilities in response to the variable needs of the pandemic, this research aimed to design mobile medical stations for COVID-19 epidemic prevention, the emergence of which began in February 2020. The mobile medical stations include a negative pressure isolation ward, a positive pressure swabbing station, a fever clinic and a laboratory. In Taiwan, many medical institutions used the mobile swabbing station design of this study to practice COVID-19 screening pre-tests. Internationally, this study assisted Palau in setting up medical stations to provide anti-epidemic goods and materials. The design of this study not only provides a highly flexible and safe medical environment but the benefits of screening can also be used as resources for medical research, forming an economic circulation for operation sustainability. In addition, the design of this study can also be used during the non-epidemic period as a healthcare station for rural areas or as a long-term community medical station.
The Effect of Transborder Mobility on COVID-19 Incidences in Belgium
Authors: Brackx Febe , Vanongeval Fien , Natalia Yessika Adelwin , Molenberghs Geert , Steenberghen Thérèse
Published: August 2022

Belgium is a geographically small country bordered by The Netherlands, France, Germany, and Luxembourg, with intense transborder mobility, defined as mobility in the border regions with neighboring countries. It is therefore of interest to examine how the 14-day COVID-19 confirmed case incidence in the border regions is influenced by that of the adjacent regions in the neighboring countries and thus, whether and how it differs from that in the adjacent non-border regions within Belgium. To this end, the 14-day COVID-19 confirmed case incidence is studied at the level of Belgian provinces, well-defined border areas within Belgium, and adjacent regions in the neighboring countries. Auxiliary information encompasses work-related border traffic, travel rates, the proportion of people with a different nationality, the stringency index of the non-pharmaceutical interventions, and the degree of urbanization at the level of the municipality. Especially in transnational urbanized areas such as between the Belgian and Dutch provinces of Limburg and between the Belgian province of Antwerp and the Dutch province of North Brabant, the impact on incidence is visible, at least at some points in time, especially when the national incidences differ between neighboring countries. In contrast, the intra-Belgian language border regions show very little transborder impact on the incidence curves, except around the Brussels capital region, leading to various periods where the incidences are very different in the Dutch-speaking north and the French-speaking south of Belgium. Our findings suggest that while travel restrictions may be needed at some points during a pandemic, a more fine-grained approach than merely closing national borders may be considered. At the same time, in border regions with considerable transborder mobility, it is recommended to coordinate the non-pharmaceutical interventions between the authorities of the various countries overlapping with the border region. While this seems logical, there are clear counterexamples, e.g., where non-essential shops, restaurants, and bars are closed in one country but not in the neighboring country.
Green Total-Factor Energy Efficiency of Construction Industry and Its Driving Factors: Spatial-Temporal Heterogeneity of Yangtze River Economic Belt in China
Authors: Ma Dalai , Zhao Na , Zhang Fengtai , Xiao Yaping , Guo Zuman , Liu Chunlan
Published: August 2022

With the proposal of the “carbon peak, carbon neutral“ goal, energy efficiency has become one of the key means to achieve energy conservation and emission reduction at this stage. The construction industry, as a cornerstone of China’s economy, is characterized by serious overcapacity, energy waste, and pollution. As a result, academic research on its energy efficiency is gaining traction. This paper employed the Super-EBM model considering undesirable output to evaluate the green total-factor energy efficiency of the construction industry (CIGTFEE) in the Yangtze River Economic Belt (YREB) from 2003 to 2018. The spatial-temporal evolution characteristics and spatial heterogeneity of CIGTFEE were analyzed in detail through geospatial analysis. Finally, the driving factors of CIGTFEE were analyzed through a spatial econometric model. The results indicated that, during the sample research period, the CIGTFEE showed a holistic growth trend with volatility. By region, the downstream CIGTFEE grew sharply until 2006 and then remained fairly stable, while the midstream conformed to the “M” trend and the upstream region showed an inverted u-shaped trend; From the perspective of spatial differentiation, the CIGTFEE in YREB shows a significant spatial agglomeration situation, while the spatial agglomeration degree weakened. It existed a ladder-shaped change trend, with the regional average CIGTFEE from high to low levels as follows: Downstream, Midstream, and Upstream, and showed an obvious polarization in the upstream and downstream. From the analysis of the driving factors, CIGTFEE is significantly promoted by economic growth, energy structure, and human capital and suppressed by urbanization level, yet the impact of technological progress and the level of technology and equipment is not significant. In summary, province-specific policies based on spatial and temporal heterogeneity were proposed to improve the CIGTFEE of YREB.
The Challenge of Reaching Undocumented Migrants with COVID-19 Vaccination
Authors: Matlin Stephen A. , Smith Alyna C. , Merone Jessica , LeVoy Michele , Shah Jalpa , Vanbiervliet Frank , Vandentorren Stéphanie , Vearey Joanna , Saso Luciano
Published: August 2022

Access to vaccination against a health threat such as that presented by the COVID-19 pandemic is an imperative driven, in principle, by at least three compelling factors: (1) the right to health of all people, irrespective of their status; (2) humanitarian need of undocumented migrants, as well as of others including documented migrants, refugees and displaced people who are sometimes vulnerable and living in precarious situations; and (3) the need to ensure heath security globally and nationally, which in the case of a global pandemic requires operating on the basis that, for vaccination strategies to succeed in fighting a pandemic, the highest possible levels of vaccine uptake are required. Yet some population segments have had limited access to mainstream health systems, both prior to as well as during the COVID-19 pandemic. People with irregular resident status are among those who face extremely high barriers in accessing both preventative and curative health care. This is due to a range of factors that drive exclusion, both on the supply side (e.g., systemic and practical restrictions in service delivery) and the demand side (e.g., in uptake, including due to fears that personal data would be transmitted to immigration authorities). Moreover, undocumented people have often been at increased risk of infection due to their role as “essential workers”, including those experiencing higher exposure to the SARS-CoV-2 virus due to frontline occupations while lacking protective equipment. Often, they have also been largely left out of social protection measures granted by governments to their populations during successive lockdowns. This article reviews the factors that serve as supply-side and demand-side barriers to vaccination for undocumented migrants and considers what steps need to be taken to ensure that inclusive approaches operate in practice.
Protection of Prisoners with Mental Health Disorders in Italy: Lights and Shadows after the Abolition of Judicial Psychiatric Hospitals
Authors: Di Mizio Giulio , Bolcato Matteo , Rivellini Gianfranco , Di Nunzio Michele , Falvo Valentina , Nuti Marco , Enrichens Francesco , Lucania Luciano , Di Nunno Nunzio , Clerici Massimo
Published: August 2022

In Italy, a person suffering from a mental disorder who commits a crime will be given a custodial security order and serve the period of admission at a Residenza per la esecuzione delle misure di sicurezza (REMS) (Residence for the Execution of Security Measures, hereinafter “REMS”). These institutions have been established recently and though equipped with the necessary safety measures, the focus is on psychiatric therapy. Despite being present on a national scale, access is very limited in terms of capacity. Immediate remedial measures are needed, so much so that the European Court of Human Rights recently condemned Italy for this very reason. This article, through a review of the constitutive principles of these institutions, shows how they have very positive aspects such as the attention to necessary psychotherapy in order to protect the right to health and the real taking charge of the fragility of the subjects; however, it is seen how there are many negative aspects linked above all to the scarce availability of places in these structures. The article provides suggestions on a more comprehensive strategy for facilities for detainees with mental disorders.
Cost-Effectiveness Analysis of the Helicobacter Pylori Screening Programme in an Asymptomatic Population in China
Authors: Feng Tianyu , Zheng Zhou , Xu Jiaying , Cao Peng , Gao Shang , Yu Xihe
Published: August 2022

Objective The aim of this study was to investigate the cost-effectiveness of Helicobacter pylori (H. pylori) screening and eradication treatment in an asymptomatic population in China and to explore the most cost-effective screening protocol for H. pylori. Method We used TreeAge 2019 to construct Markov models to assess the direct healthcare costs and quality-adjusted life years (QALYs) and the cost per year of life saved (YoLS) of three therapies, i.e., annual, triennial and five-yearly H. pylori screening. Excess probabilities were derived from published high quality studies and Meta-analyses, and costs and utilities were derived from the Chinese Yearbook of Health Care Statistics and published studies. Incremental cost-effectiveness ratios (ICERs) were used to describe the results. The willingness-to-pay threshold was set at China’s Gross National Product per capita. Result In the asymptomatic population, the ICER per QALYs gained was US$1238.47 and US$1163.71 for every three and five years of screening compared to the annual screening group; the ICER per YoLS gained was US$3067.91 and US$1602.78, respectively. Conclusion Screening for H. pylori in asymptomatic populations in China and eradicating treatment for those who test positive is cost-effective. Increasing screening participation in asymptomatic populations is more effective than increasing the frequency of screening. From a national payer perspective, it is cost-effective to screen the general asymptomatic population in China for H. pylori and to eradicate those who test positive. Individuals need to choose a screening programme that they can afford according to their financial situation.
Effects of Chronic Diseases on All-Cause Mortality in People with Mental Illness: A Retrospective Cohort Study Using the Korean National Health Insurance Service-Health Screening
Authors: Son Sujin , Kim Yun Jin , Kim Seok Hyeon , Kim Johanna Inhyang , Kim Sojung , Roh Sungwon
Published: August 2022

The aim of this study was to compare mortality and the prevalence of chronic diseases between people with mental illness and the general population, and to explore which chronic diseases increase the risk of all-cause mortality, especially in people with mental illness. This study assessed data from the 2002–2019 Korean National Health Insurance Service-Health Screening sample cohort. Results revealed that all-cause mortality was higher in people with mental illness compared to people without mental illness (11.40% vs. 10.28%, p = 0.0022). Several chronic diseases have a higher prevalence and risk of all-cause mortality in individuals with mental illness than the general population. Among people with the same chronic disease, those with mental disorders had a higher risk of all-cause mortality. Cancer (aHR 2.55, 95% CI 2.488–2.614), liver cirrhosis (aHR 2.198, 95% CI 2.086–2.316), and arrhythmia (aHR 1.427, 95% CI 1.383–1.472) were the top three chronic diseases that increased the risk of all-cause mortality in people with mental illness compared to people without mental illness. Our results suggest the need for more attention to chronic diseases for people with mental illness in clinical practice by explaining the effect of chronic disease on all-cause mortality in people with mental illness.
Study on the Coupling Coordination between New-Type Urbanization and Water Ecological Environment and Its Driving Factors: Evidence from Jiangxi Province, China
Authors: Kan Daxue , Ye Xinya , Lyu Lianju , Huang Weichiao
Published: August 2022

With the rapid development of urbanization, problems such as the degradation of water ecological environment have emerged. How to improve the water ecological environment in the process of urbanization has become one of the urgent problems facing policy makers. This paper studies the coupling coordination relationship between new-type urbanization and water ecological environment, with the purpose of using insights gained from the study to help improve the quality of water ecological environment and promote sustainable development of water ecological environment. We take 11 cities in China’s Jiangxi Province as the research object, and construct the coupling coordination evaluation indicator system of new-type urbanization and water ecological environment, then using the coupling coordination degree model to examine the state of coupling coordination between new-type urbanization and water ecological environment from 2009 to 2019. We further explore its driving factors employing random effect panel Tobit model. The results show that: (1) The level of new-type urbanization in Jiangxi Province shows a steady upward trend, and the water ecological environment level tends to rise steadily and slowly, although the comprehensive score of water ecological environment in most cities is lower than 0.1, indicating that the situation of water ecological environment is not optimal yet and there is room for improvement. (2) In 2009, 2014 and 2019, the coupling coordination development level between new-type urbanization and water ecological environment in Jiangxi Province showed an upward trend, from moderate maladjustment recession to mild maladjustment recession, and from low coupling coordination to moderate coupling coordination, although the overall coupling coordination degree was low. (3) The investment in scientific and technological innovation, degree of opening-up and government capacity are positively correlated with the coupling coordination degree, while economic development level, resource agglomeration ability, education level and industrialization level are negatively correlated with the coupling coordination degree. These results can provide insights to support new-type urbanization and water ecological environment in the future, and hold great significance for urban sustainable development.
Heterogeneous Impact of Social Integration on the Health of Rural-to-Urban Migrants in China
Authors: Lu Haiyang , Kandilov Ivan T. , Nie Peng
Published: August 2022

Background: While several studies have found that lower levels of social integration may lead to a deterioration in the health status of migrants, previous research on the nexus between social integration and health has generally ignored the potential endogeneity of social integration. This paper examines the heterogeneous impact of social integration on the health of rural-to-urban migrants in China by exploiting plausibly exogenous, long-term, geographic variation in dialectal diversity. Methods: Drawing on nationally representative data from the 2017 China Migrants Dynamic Survey (n = 117,446), we first regressed self-reported health on social integration using ordinary least squares estimation and then used an ordered probit model as a robustness check. Additionally, to rule out the potential endogeneity of social integration, we relied mainly on an instrumental variable approach and used dialectal diversity as a source of exogenous variation for social integration. Results: We found that social integration has a significant positive impact on rural-to-urban migrants’ health. We also detected considerable heterogeneity in the effects of social integration across gender, generation, and wage levels: the health status of women, more recent generation migrants, and migrants with wages in the middle of wage distribution are more likely to be affected by social integration. Conclusions: We confirmed the beneficial impact of social integration on migrants’ health, which has some important policy implications. Successful migration policies should take the fundamental issue of migrants’ social integration into account.
Restoring TRAILR2/DR5-Mediated Activation of Apoptosis upon Endoplasmic Reticulum Stress as a Therapeutic Strategy in Cancer
Authors: Mora-Molina Rocío , López-Rivas Abelardo
Published: August 2022

The uncontrolled proliferation of malignant cells in growing tumors results in the generation of different stressors in the tumor microenvironment, such as nutrient shortage, hypoxia and acidosis, among others, that disrupt endoplasmic reticulum (ER) homeostasis and may lead to ER stress. As a response to ER stress, both normal and tumor cells launch a set of signaling pathways known as the unfolded protein response (UPR) to restore ER proteostasis and maintain cell viability and function. However, under sustained ER stress, an apoptotic cell death process can be induced and this has been the subject of different review articles, although the role of the TRAIL-R2/DR5-activated extrinsic pathway of apoptosis has not yet been thoroughly summarized. In this Review, we provide an updated overview of the molecular mechanisms regulating cell fate decisions in tumor cells undergoing ER stress and discuss the role of the tumor necrosis factor (TNF)-related apoptosis-inducing ligand receptor 2 (TRAIL-R2/DR5) in the final outcome of UPR signaling. Particularly, we focus on the mechanisms controlling cellular FLICE-like inhibitory protein (FLIP) levels in tumor cells undergoing ER stress, which may represent a potential target for therapeutic intervention in cancer.
A Novel Drug Modulator Diarylheptanoid (trans-1,7-Diphenyl-5-hydroxy-1-heptene) from Curcuma comosa Rhizomes for P-glycoprotein Function and Apoptosis Induction in K652/ADR Leukemic Cells
Authors: Viriyaadhammaa Natsima , Duangmano Suwit , Saiai Aroonchai , Tungjai Montree , Dejkriengkraikul Pornngarm , Tima Singkome , Chiampanichayakul Sawitree , Krise Jeffrey , Anuchapreeda Songyot
Published: August 2022

Curcuma comosa has been used in traditional Thai medicine to treat menstrual cycle-related symptoms in women. This study aims to evaluate the diarylheptanoid drug modulator, trans-1,7-diphenyl-5-hydroxy-1-heptene (DHH), in drug-resistant K562/ADR human leukemic cells. This compound was studied due to its effects on cell cytotoxicity, multidrug resistance (MDR) phenotype, P-glycoprotein (P-gp) expression, and P-gp function. We show that DHH itself is cytotoxic towards K562/ADR cells. However, DHH did not impact P-gp expression. The impact of DHH on the MDR phenotype in the K562/ADR cells was determined by co-treatment of cells with doxorubicin (Dox) and DHH using an MTT assay. The results showed that the DHH changed the MDR phenotype in the K562/ADR cells by decreasing the IC50 of Dox from 51.6 to 18.2 µM. Treating the cells with a nontoxic dose of DHH increased their sensitivity to Dox in P-gp expressing drug-resistant cells. The kinetics of P-gp mediated efflux of pirarubicin (THP) was used to monitor the P-gp function. DHH was shown to suppress THP efflux and resulted in enhanced apoptosis in the K562/ADR cells. These results demonstrate that DHH is a novel drug modulator of P-gp function and induces drug accumulation in the Dox-resistant K562 leukemic cell line.
Recombinant Human Arresten and Canstatin Inhibit Angiogenic Behaviors of HUVECs via Inhibiting the PI3K/Akt Signaling Pathway
Authors: Zhu Lingyu , Guo Zitao , Zhang Ji , Yang Yuliang , Liu Chunyu , Zhang Liang , Gu Zhenghua , Li Youran , Ding Zhongyang , Shi Guiyang
Published: August 2022

Angiogenetic inhibitors are crucial in tumor therapy, and endogenous angiogenesis inhibitors have attracted considerable attention due to their effectiveness, safety, and multi-targeting ability. Arresten and canstatin, which have anti-angiogenesis effects, are the c-terminal fragments of the α1 and α2 chains of type IV collagen, respectively. In this study, human arresten and canstatin were recombinantly expressed in Escherichia coli (E. coli), and their effects on the proliferation, migration and tube formation of human umbilical vein endothelial cells (HUVECs) were evaluated. Regarding the cell cycle distribution test and 5-ethynyl-2′-deoxyuridine (EdU) assays, arresten and canstatin could repress the proliferation of HUVECs at a range of concentrations. Transwell assay indicated that the migration of HUVECs was significantly decreased in the presence of arresten and canstatin, while tube formation assays suggested that the total tube length and junction number of HUVECs were significantly inhibited by these two proteins; moreover, they could also reduce the expression of vascular endothelial growth factor (VEGF) and the phosphorylation levels of PI3K and Akt, which indicated that the activation of the 3-kinase/serine/threonine-kinase (PI3K/Akt) signaling pathway was inhibited. These findings may have important implications for the soluble recombinant expression of human arresten and canstatin, and for the related therapy of cancer.