bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS PENGARUH MODAL, TENAGA KERJA DAN BAHAN BAKU TERHADAP PENDAPATAN PKL NASI BORAN DI KECAMATAN LAMONGAN
Authors: Wulandari Dina Tri , Priyono Joko
Published: May 2023

The purpose of the study was to find out about the analysis of the effect of capital, labor and raw materials on the income of PKL boran rice in Lamongan District. The variables used in this study are Capital (X1), Labor (X2) and Raw Materials (X3) and Income (Y). Data were collected through questionnaires filled out by boran rice traders in Lamongan District. The sample in this study were 30 respondents. The type of research used is a quantitative method using multiple linear regression analysis, t test, F test with the help of the SPSS program. Based on the results show that all variables, namely Capital, Labor and Raw Materials have a significant effect on the income of boran rice traders in Lamongan District. Based on the results of the t test on the X1 variable, it shows that the capital t count (X1) is 9.062 > t table 2.05183 and the significance value for the modal variable (X1) is 0.000 which is smaller than the level of = 0.05 (0.000 < 0.05). From these results it can be concluded that Capital (X1) has a positive and significant effect on the income of boran rice in Lamongan District. Thus in this study reject the hypothesis H0. Variable X2 shows the t count of labor (X2) is 3.403 > t table 2.05183 and the significance value for the labor variable (X2) is 0.002 which is stated to be smaller than 0.05. From these results, it can be concluded that the labor variable (X2) has a positive and significant influence on the income of boran rice in Lamongan District. Thus in this study reject the hypothesis H0. Variable X3 shows the t count of raw materials (X3) is 3.532 > t table 2.05183 and the significance value for the raw material variable (X3) is 0.002, which is lower than 0.05. From these results, it can be concluded that the raw material variable (X3) has a positive and significant effect on the income of boran rice in Sidokumpul Village, Lamongan District. Thus in this study reject the hypothesis H0. The result of the F test is 224.314 with a significant level of 0.000. Because the significance value is smaller than 0.05. Ha is accepted and H0 is rejected so that capital (X1), labor (X2) and raw materials (X3) together affect the income (Y) of boran rice. in Lamongan District, Lamongan Regency
PENENTUAN PRIORITAS PEMELIHARAAN JALAN KABUPATEN BERDASARKAN KETERSEDIAAN DANA DAN WAKTU
Authors: Purwanto Utomo Adhitya Putra , Oetomo Wateno
Published: May 2023

Prasarana jalan merupakan sarana dan prasarana publik yang harus dapat dirasakan keberadaannya oleh seluruh lapisan masyarakat maka sebagai konsekuensinya hak penguasaan dan wewenangnya dilakukan oleh pemerintah dan diharapkan setiap daerah mampu mengembangkan sistem penyelenggaraan pelayanan kepada masyarakat yang lebih akomodatif terhadap kebutuhan masyarakat setempat agar prasarana tersebut dapat dirasakan sebaik mungkin maka perlu dibutuhkan pemeliharaan akan prasarana tersebut.Tujuan dari penulisan tesis ini adalah untuk mengidentifikasi tingkat kerusakan jalan untuk menuntukan skala prioritas penanganan dan mengevaluasi, mengestimasi dan merencanakan pekerjaan berdasarkan biaya yang dianggarkan dan waktu dengan metode Methode Analytcal Hierarchy Process.  Hasil dari penelitian ini adalah Identifikasi data jaringan dan kerusakan jalan pada ruas-ruas jalan kabupaten di Wilayah Selatan Kabupaten Lamongan untuk mendapatkan penanganan sesuai kebutuhan. Adapun kriteria yang memperoleh prioritas paling tinggi adalah kondisi struktur jalan dengan bobot 61 %, prioritas kedua kriteria kondisi lalu lintas dengan bobot 30 %, dan prioritas ketiga kriteria kondisi jenis perkerasan dengan bobot 0,09 %
FAKTOR-FAKTOR YANG BERPENGARUH TERHADAP KETERLAMBATAN PELAKSANAAN PEKERJAAN PENINGKATAN/PELEBARANJALAN GONDORUSO-JUGOSARI KECAMATAN PASIRIAN KABUPATEN LUMAJANG
Authors: Prayitno Hendri , Witjaksana Budi , Huda Miftahul
Published: May 2023

Implementation of a project is very rarely encountered a project that runs exactly as planned. Project delays are often a source of disputes and claims between the owner and the contractor, so the value will be very expensive in terms of both the contractor and the owner. In general, project delays often occur due to changes in planning during the implementation process, poor managerial and contracting organizations, work plans that are not well managed and integrated, drawings and specifications are incomplete, or the contractor's failure to carry out the work.

             This study aims to determine the factors that influence the delay in the implementation of the work on the improvement / widening of the gondoruso-jugosari road in the district of Pasirian Lumajang district and the efficiency of time and cost of the project after the addition of the optimum workers in the improvement / widening project of Jalan Gondoruso - Jugosari, Pasirian District, Lumajang Regency. Analysis using regression analysis and crash program methods.

             Based on the results of the analysis concluded that the factors that influencefor delays in carrying out the work improvement / widening of Gondoruso - Jugosari Road, Pasirian District Lumajang Regency is a factor of the Work Environment and Materials / Materials and the result of acceleration using the crashing method with the addition of 14% of the workforce obtained an acceleration of 6 days from a total duration of 54 days for the work of Concrete Pavement Pavement with Single Reinforced Matting (Fs 45 cm thick 25 cm) to 48 days with a cost slope of Rp. 99,281,345,15.
ANALISIS INVESTASI PADA PROYEK PEMBANGUNAN JALAN TOL PASURUAN - PROBOLINGGO
Authors: Abimanyu Angga , Mudjanarko Sri Wiwoho , Moetriono Hary
Published: May 2023

Toll roads are public roads that are part of the road network system and as national roads, for which users are required to pay tolls. The existence of toll roads is very important in the smooth flow of traffic along with the increasing amount of traffic caused by the increase in the number of vehicles and the condition of arterial road pavements that have been damaged (wavy and cracked) at several locations on the road and congestion that occurs due to damaged roads. damaged. The benefits of toll road operations are to influence regional development and economic improvement, as well as increase mobility and accessibility of people and goods, also provide benefits to users in the form of saving vehicle operating costs (BOK) and time compared to passing through non-toll roads, as well as providing returns on investment, maintenance, and toll road development for the Business Entities involved. One form of cooperation between the government and the private sector is the construction of the Pasuruan-Probolinggo (Paspro) Toll Road. Through the Toll Road Business Entity (BUJT) PT. Trans-Java Paspro Toll Road, the government cooperates in the construction of a 31 km toll road. PT. Trans-Java Paspro Toll Road received a 45-year concession to operate the toll road. The purpose of this study was to determine the investment feasibility of the Pasuruan-Probolinggo Toll Road based on the investment feasibility parameters of Net Present Value (NPV), Benefit Cost Ratio (B/C Ratio), Internal Rate Return (IRR), Payback Period (PBP), and determine the length of time. payback period (Payback Period) Pasuruan-Probolinggo Toll Road, and get a comparison of Vehicle Operating Costs (BOK) between Toll Roads and Arterial Roads. The final result of the analysis obtained that the NPV value was negative Rp. -1,773,803,000,000, and the IRR value is 9.56%, which is smaller than WACC = 13.07%, and the BCR value is less than 1.00, which is 0.763 so that it can be seen that the investment is not financially feasible for investors. However, BEP < 45 years concession period is April 2043, so it can be seen that it is still in the feasible category. The Vehicle Operational Cost (BOK) for arterial roads is Rp. 3,647/km for Goal I, Rp. 6,413/km for Gol II, Rp. 9,498/km for Gol III, Gol IV, and Gol V. Meanwhile, BOK for toll roads and added toll tariffs of Rp. 3.226/km for Goal I, Rp. 6,767/km for Gol II, Rp. 7,763/km for Gol III, Rp. 8.113/km for Gol IV and Rp. 8,463 for Gol V. From the analysis it is known that the cost of passing through the toll road is cheaper than going through the arterial road for all vehicle classes and is certainly very beneficial for toll road users.
Judicial Review in Public Law: Balancing Democracy and Constitutional Rights
Authors: Hassan Ali
Published: May 2023

Judicial Review in Public Law: Balancing Democracy andConstitutional Rights
Learning from Heraclitus to Better Understand Genocidal Regimes
Authors: Matoo Anil Singh
Published: May 2023

This article will argue that from Heraclitus’ writings on fire, we can better appreciate how genocidal regimes use it against a target population. In doing so, I am not arguing that I have presented the proper reading of Heraclitus’ thoughts. Rather, I have tried to approach the available Fragments in a way whereby we can learn from Heraclitus about the potentially genocidal dangers and consequences of fire. To do this, I will approach Heraclitus’ Fragments through a framework provided by Martin Heidegger. Ultimately, I will argue that from Heraclitus’ thoughts we can better comprehend how tyrannical regimes utilise fire to exact genocides.
Data Analytics Consulting: Unlocking Insights for Business Growth Jordon Smith
Authors: Ali Saad
Published: May 2023

Data Analytics Consulting: Unlocking Insights for Business GrowthJordon Smith
Public Law and Administrative Decision-Making
Authors: Hassan Ali
Published: May 2023

Public Law and Administrative Decision-Making
Sumber Hukum Tata Negara dan Hukum Administrasi Negara
Authors: Efendi Mukmin
Published: May 2023

Tulisan ini disusun dalam rangka memenuhi tugas dalam mata kuliah HTN/HAN. Tulisan ini memuat beberapa penjelasan terkait “Sumber Hukum Tata Negara dan Hukum Administrasi Negara” yang mengumpulkan keterangan dari beberapa buku yang disesuaikan dengan pembahasan terkait. Tulisan ini pun nantinya dimaksudkan untuk disesuaikan dengan standar yang ditetapkan.
Psikologi kepemimpinan
Authors: Zebua Rony Sandra Yofa
Published: May 2023

Buku Ini Membahas Tentang: psikologi kepemimpinan, kepemimpinan yang efektif, teori peran: teori pertukaran pemimpin dan teori atribusi, teori kontingensi, kepemimpinan kharismatik, kepemimpinan transformasional, perubahan dalam organisasi, kepemimpinan dan kelompok, kepemimpinan strategis para eksekutif, keterampilan negosiasi.
Major concerns about a published article in Human reproduction journal
Authors: Maged Ahmed Mohamed
Published: May 2023

We have read the article entitled “Increased versus standard gonadotrophin dosing in predicted poor responders of IVF: an open-label randomized controlled trial.” (1) that was published in your journal with great interest. However, some of its data was not fully clear. So, we searched the trial registration (2), the published abstract and the final published article. These evaluations revealed Major concerns
Public Law and Human Rights: Balancing State Sovereignty and International Obligations
Authors: Hassan Ali
Published: May 2023

Public Law and Human Rights: Balancing State Sovereignty andInternational Obligations
INFLASI DAN PENGANGGURAN DALAM EKONOMI ISLAM
Authors: gunawan sahrul
Published: May 2023

Pada dasarnya, ekonomi Islam bertujuan untuk mencapai falah atau dapat dikatakan juga untuk mencapai kesejahteraan umat. Dengan adanya inflasi, maka tujuan untuk mensejahterakan umat semakin sulit dicapai. Maka dari itu untuk mengatasi permasalahan inflasi yang dapat menyulitkan Islam untuk mencapai tujuannya.Pengangguran merupakan sebutan dari mereka yang tidak memiliki pekerjaan atau sedang mencari pekerjaan. Penganguran adalah suatu keadaan dimana seseorang tergolong ke dalam angkatan kerja yang ingin mendapatkan pekerjaan, namun mereka belum memperoleh pekerjaan tersebut.Resume ini dibuat utuk memenuhi tugas mata kuliah ekonomi mikro
Comments on an article
Authors: Maged Ahmed Mohamed
Published: May 2023

We have read the article entitled “Pessary Compared With Vaginal Progesterone for the Prevention of Preterm Birth in Women With Twin Pregnancies and Cervical Length Less Than 38 mm: A Randomized Controlled Trial.” (1) that was published in your journal with great interest. However, some of its data was not fully clear. So, we searched the trial registration (2) and the changes that were made by the authors over time, the published abstract (3) and the final published article. These evaluations revealed major concerns
Differential expression of CLDN1 in cancer of the skin: malignant melanoma.
Authors: Mamoor Shahan
Published: May 2023

Skin cancer is diagnosed in nearly 1.5 million patients each year (1). While patients with basal and squamous cell carcinomas are provided with 5-year survival rates at nearly 100% and 90%, respectively, patients diagnosed with cutaneous melanoma (metastatic melanoma) are provided 5-year survival rates at 91.4% at stage I and 24.6% at stage IV (2-5). We mined published microarray datasets (6, 7) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with the deadliest type of skin cancer, malignant melanoma. We found significant differential expression of the gene encoding claudin 1, CLDN1, when comparing melanoma tumor tissue from the human skin to the tissue of origin. CLDN1 mRNA was present at significantly lower quantities in melanoma tissues as compared to normal tissues from the skin. Analysis of human survival data revealed that expression of CLDN1 in melanoma tissues was not correlated with overall survival in patients with malignant melanoma. CLDN1 expression changes may be important for the initiation or progression of malignant melanoma in humans.
IMPLEMENTASI PERDAMAIAN SEBAGAI LANDASAN TEOLOGI SHALOM PADA SAAT INI ANTARA UMAT BERAGAMA
Authors: Londong Rismayuni Sarah
Published: May 2023

Abstrak: Kajian dalam tulisan ini mencoba menjelaskan masalah konflik perdamaian yang sedang dihadapi diberbagai daerah di Indonesia. Perlu dilakukan cara damai untuk menghadirkan perdamaian di bangsa yang multikultural. Dari analisis berbagai literatur dan teks Alkitab ada beberapa implementasi perdamaian yang harus dipahami bahwa perdamaian harus menuntut seseorang menerima dirinya sendiri ditengah keberagaman, karena implementasi perdamaian memberikan bimbingan untuk menghindari prasangka buruk. Perlunya dibangun pengertian serta sikap yang menghargai keragaman etnis, perbedaan agama, perbedaan jenis kelamin, status sosial seperti kaya miskin dan perbedaan kelompok. Dalam upaya membangun jalan menuju perdamaian maka kita seharusnya memahami adanya keragaman, memahami konflik, membangun sikap menolak kekerasan, adanya kerelaan untuk memulai mengakui kesalahan dan kerelaan untuk memberi maaf.
SISTEM PEMERINTAHAN DAN PEMBAGIANNYA
Authors: AHMAD HABIB HUSEIN
Published: May 2023

Tulisan ini membahas template tugas Ilmu Hukum Tata Negara / Hukum Administrasi Negara yang bertujuan untuk membantu memahami materi pengertian sistem pemerintahan dan pembagiannya. Metode yang digunakan adalah bersifat resume dengan pendekatan integrasi ilmu sehingga tulisan ini banyak mengambil istilah atau pengertian dari banyak sumber ( buku ). Hasil template yang bersifat resume ini menunjukkan bahwa template tugas Ilmu Hukum Tata Negara sangat penting untuk mahasiswa dalam rangka menuntaskan tugas perkuliahan. Tanpa adanya template tugas, mahasiswa menyusun tugas dengan model yang sangat beragam. Kondisi yang terakhir ini mengakibatkan tugas tidak disusun berdasarkan standar yang telah ditetapkan.
Analisis Antropologi tentang Konsep "Unnalli Melo"
Authors: Mayor Abraham
Published: May 2023

Makalah ini adalah hasil pengembangan teori antropologi yang diterapkan pada paham Unnalli Melo dan pengaruhnya terhadap pembentukan karakter masyarakat di Toraja. Kajian ini menyajikan dan memberikan pemahaman yang mendalam tentang konsep antropologi dalam konteks paham Unnalli Melo, serta implikasinya terhadap pertumbuhan dan pembentukan nilai-nilai karakter dalam masyarakat Toraja.
Strategic decisions and eye tracking data
Authors: Gelden Victoria
Published: May 2023

Recently, there has been a growing interest in the use of eye gaze. through a well-established gaze tracking method in psychology. The study of economic decision making. The purpose is to find Behavioral insights that are not basedly available Based only on observed choice data. At the same time, the opposite with expensive and complex procedures such as fMRI; Eye-tracking allows subjects to be tested under certain conditions. Standard tests showed similar conditions. Behavioral experiments.
Teknologi Pendidikan
Authors: Mesra Romi
Published: May 2023

Teknologi pendidikan merupakan aplikasi sistematis dari proses dan sumber teknologi yang relevan dalam pengajaran, dengan tujuan untuk meningkatkan kinerja siswa. Ini melibatkan pendekatan disiplin untuk mengidentifikasi kebutuhan siswa, menerapkan teknologi dalam instruksi, dan melacak kinerja mereka. Buku ini terdiri dari lima belas bab. Bab pertama tentang konsep dasar teknologi pendidikan, bab dua tentang pengembangan teknologi pendidikan, bab tiga tentang kawasan & ranah teknologi pendidikan, bab empat tentang teknologi pendidikan dalam membentuk karakter bangsa, bab lima tentang teknologi pendidikan dalam masyarakat, bab enam tentang peran teknologi pendidikan dalam implementasi kurikulum merdeka belajar, bab tujuh tentang peningkatan kompetensi guru & dosen melalui teknologi pendidikan, bab delapan tentang perkembangan teknologi komunikasi & dampaknya terhadap pendidikan, bab sembilan tentang pemanfaatan teknologi pendidikan pada pergururuan tinggi, bab sepuluh tentang klasifikasi media pembelajaran, bab sebelas tentang pemanfaatan teknologi pendidikan sekolah, bab dua belas tentang teknologi pendidikan & teori pembelajaran, bab tiga belas tentang teknologi sebagai pendekatan dalam praktik pendidikan, dan bab empat belas tentang teknologi sebagai pendekatan dalam permasalahan pendidikan, bab lima belas tentang penerapan teknologi pendidikan di negara maju dan berkembang
Diffusion MRI Data Processing and Analysis: A Practical Guide with ExploreDTI
Authors: Connaughton Michael , Leemans Alexander , O’Hanlon Erik , McGrath Jane
Published: May 2023

This chapter introduces neuroimaging researchers to the concepts and techniques of diffusion magnetic resonance imaging data processing. Using the freely available ExploreDTI software, we provide a step-by-step guide for processing multi-shell High Angular Resolution Diffusion Imaging data and generating tractography based on constrained deconvolution. Brief explanations of the rationale behind each processing step are provided to aid the researcher in understanding the concepts and principles involved. Potential processing pitfalls will be discussed, and tips for troubleshooting common issues will be provided. An addtional step-by-step guide for processing DTI data using the open-access AOMIC data set is also provided, demonstrating command-line that can also be applied to process other large neuroimaging datasets.
Differential expression of CASP14 in cancer of the skin: malignant melanoma.
Authors: Mamoor Shahan
Published: May 2023

Skin cancer is diagnosed in nearly 1.5 million patients each year (1). While patients with basal and squamous cell carcinomas are provided with 5-year survival rates at nearly 100% and 90%, respectively, patients diagnosed with cutaneous melanoma (metastatic melanoma) are provided 5-year survival rates at 91.4% at stage I and 24.6% at stage IV (2-5). We mined published microarray datasets (6, 7) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with the deadliest type of skin cancer, malignant melanoma. We found significant differential expression of the gene encoding caspase 14, CASP14, when comparing melanoma tumor tissue from the human skin to the tissue of origin. CASP14 mRNA was present at significantly lower quantities in melanoma tissues as compared to normal tissues from the skin. Analysis of human survival data revealed that expression of CASP14 in melanoma tissues was not correlated with overall survival in patients with malignant melanoma. CASP14 expression changes may be important for the initiation or progression of malignant melanoma in humans.
Pengaruh Unnalli Melo dalam Konteks Pembentukan Moral dan Karakter Anak Toraja
Authors: Palangga Bersyeba Merita
Published: May 2023

AbstractThe moral and character of the child will be formed if influenced by the habits that exist in the surrounding environment. Of course the expected positive influence in the formation of morals and character. The author hopes that this study can answer the positive influence on the moral growth and character of children through the ideology of the Toraja people which is referred to as Unnalli Melo.
Buku Ajar Hukum Dagang
Authors: Mesra Romi
Published: May 2023

Buku ajar hukum dagang adalah buku yang bisa dijadikan referensi untuk pelaksanaan pembelajaran pada mata kuliah hukum dagang maupun sebagai bahan bacaan bagi akademisi dan pihak-pihak terkait dimana buku ini membahas tentang pengantar hukum dagang, prinsip umum yang berlaku pada semua kasus, perusahaan, usaha mikro, kecil dan menengah (UMKM), dan penjualan barang.Di dalam buku ini akan dijelaskan secara detail mulai dari Konsep Pengertian Hukum Dagang, Sumber-sumber Hukum Dagang, Sejarah Hukum Dagang, Tujuan Hukum Dagang, Prinsip Umum Kontrak, Agen, Kemitraan, Korporasi, Garansi atau Penjaminan, Definisi perusahaan, Fitur Perusahaan, Macam-macam perusahaan, Kepribadian Perusahaan, Perusahaan Sebagai Bagian Masyarakat dan masih banyak lagi berkaitan dengan materi hukum dagang lainnya
Differential expression of ACAP3 in cancer of the skin: malignant melanoma.
Authors: Mamoor Shahan
Published: May 2023

Skin cancer is diagnosed in nearly 1.5 million patients each year (1). While patients with basal and squamous cell carcinomas are provided with 5-year survival rates at nearly 100% and 90%, respectively, patients diagnosed with cutaneous melanoma (metastatic melanoma) are provided 5-year survival rates at 91.4% at stage I and 24.6% at stage IV (2-5). We mined published microarray datasets (6, 7) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with the deadliest type of skin cancer, malignant melanoma. We found significant differential expression of the gene encoding ArfGAP with coiled-coil, ankyrin repeat and PH domains 3, ACAP3, when comparing melanoma tumor tissue from the human skin to the tissue of origin. ACAP3 mRNA was present at significantly lower quantities in melanoma tissues as compared to normal tissues from the skin. Analysis of human survival data revealed that expression of ACAP3 in melanoma tissues was not correlated with overall survival in patients with malignant melanoma. ACAP3 expression changes may be important for the initiation or progression of malignant melanoma in humans.
Peran Kekristenan Terhadap Nilai-nilai Perdamaian Bagi Masyarakat Di Toraja
Authors: Belo Yosfina Tandi
Published: May 2023

Tujuan dari penulisan ini ialah untuk mengetahui bagaimana Peran Kekristenan Terhadap Nilai-nilai Perdamaian Bagi Masyarakat Di Toraja. Perdamaian kerap terjadi dan dipertunjukkan apabila ada masalah ataupun pertikaian yang sering terjadi, baik itu dalam lingkup pemerintahan, dalam lingkup masyarakat, dan juga dalam lingkup beragama. Dalam peran kekristenan bahkan kita manusia sebagai orang yang percaya yang menganut yang menganut kekristenan perdamaian juga merupakan salah satu hal luar biasa yang harus dilaksanakan. Secara khusus pada lingkungan masyarakat kristen Toraja yang juga ditemukan wujud perdamaian yang luar biasa. Perdamaian yang ada antara masyarakat lokal dengan masyarakat pendatang dan perdamaian antara agama dan budaya.
Filsafat Postmodernisme dan Konstruksi Identitas Budaya: Menelaah Keragaman dan Dinamika Budaya dalam Era Kontemporer
Authors: Kananlua' Mexwindi Mexin
Published: May 2023

Dalam konteks globalisasi dan perubahan sosial yang cepat, keragaman budaya menjadi semakin kompleks dan dinamis. Konsep identitas budaya telah mengalami transformasi signifikan, dengan individu-individu yang menghadapi tantangan baru dalam membangun dan mempertahankan identitas mereka. Filsafat postmodernisme menawarkan perspektif yang relevan dalam memahami dinamika budaya saat ini. Pendekatan ini menekankan pada fragmentasi, pluralitas, dan dekonstruksi dalam budaya. Konsep seperti pencampuran budaya, hibriditas, dan pluralisme identitas menjadi penting dalam konteks postmodernisme. Artikel ini mengeksplorasi bagaimana gagasan-gagasan postmodernisme ini dapat digunakan untuk memahami konstruksi identitas budaya dalam konteks keragaman budaya yang kompleks. Selain itu, artikel ini juga membahas dampak teknologi informasi dan media sosial dalam membentuk identitas budaya. Internet dan media sosial telah memfasilitasi interaksi antarbudaya yang intensif dan beragam. Masyarakat kontemporer semakin terhubung, menghasilkan pertukaran budaya yang luas dan berdampak pada konstruksi identitas budaya.
Differential expression of CCDC3 in cancer of the skin: malignant melanoma.
Authors: Mamoor Shahan
Published: May 2023

Skin cancer is diagnosed in nearly 1.5 million patients each year (1). While patients with basal and squamous cell carcinomas are provided with 5-year survival rates at nearly 100% and 90%, respectively, patients diagnosed with cutaneous melanoma (metastatic melanoma) are provided 5-year survival rates at 91.4% at stage I and 24.6% at stage IV (2-5). We mined published microarray datasets (6, 7) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with the deadliest type of skin cancer, malignant melanoma. We found significant differential expression of the gene encoding coiled-coil domain-containing 3, CCDC3, when comparing melanoma tumor tissue from the human skin to the tissue of origin. CCDC3 mRNA was present at significantly lower quantities in melanoma tissues as compared to normal tissues from the skin. Analysis of human survival data revealed that expression of CCDC3 in melanoma tissues was not correlated with overall survival in patients with malignant melanoma. CCDC3 expression changes may be important for the initiation or progression of malignant melanoma in humans.
“ALIRAN EPICUREANISME : KETIDAK PUASAN MANUSIA DALAM PERSPEKIF IBRANI 13: 5”
Authors: Patandung Jey
Published: May 2023

AbstractMan is one of God's dreams, where man is entrusted by God to guard and preserve God's other creations. But with the development of the times, humans certainly have desires that are followed continuously. So that man is not aware of his duties and responsibilities, and always has an attitude of dissatisfaction with what he has. In this journal, the author uses qualitative methods to find out and explore existing problems. Epicureanism is also one of the schools that can see human discontent from the perspective of Hebrews 13:5.
Differential expression of IL1R2 in cancer of the skin: malignant melanoma.
Authors: Mamoor Shahan
Published: May 2023

Skin cancer is diagnosed in nearly 1.5 million patients each year (1). While patients with basal and squamous cell carcinomas are provided with 5-year survival rates at nearly 100% and 90%, respectively, patients diagnosed with cutaneous melanoma (metastatic melanoma) are provided 5-year survival rates at 91.4% at stage I and 24.6% at stage IV (2-5). We mined published microarray datasets (6, 7) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with the deadliest type of skin cancer, malignant melanoma. We found significant differential expression of the gene encoding interleukin 1 receptor type 2, IL1R2, when comparing melanoma tumor tissue from the human skin to the tissue of origin. IL1R2 mRNA was present at significantly lower quantities in melanoma tissues as compared to normal tissues from the skin. Analysis of human survival data revealed that expression of IL1R2 in melanoma tissues was correlated with overall survival in patients with malignant melanoma. IL1R2 expression changes may be important for the initiation or progression of malignant melanoma in humans.
Balancing improvements to avoid out-of-area placements in acute psychiatric inpatient care
Authors: Manzi Sean , Pitt Martin
Published: May 2023

BackgroundIncreasing pressures on acute adult NHS mental health services have led to the practice of sending patients out of their home county when there is insufficient local capacity to provide them with an acute psychiatric inpatient bed. AimsThis study sought to determine how rates of referrals, bed capacity and length of stay could be improved to avoid sending people out of their local area for care.MethodA discrete event simulation approach was applied to a mental health trust in the South West of England.ResultsThe model demonstrated that to achieve zero out-of-area placements the rate of referrals would have to be halved, bed capacity would have to be increased from 78 to 123 beds or length of stay would have to halve. If changes were made to all three elements of the system between 85 and 93 beds would be required in combination with between a 22% and 44% reduction in the rate of referrals and between a 11% and 21% reduction in length of stay.ConclusionsDue to non-linear effects in the system, avoiding the need to send patients out-of-area for care can best be achieved by improving multiple elements of the system in combination.
Experiment ended
Authors: Bard AI
Published: May 2023

The UKHSA Science Strategy 2023 to 2033: Securing Health and Prosperity is a rational plan that is based on sound scientific evidence. The strategy identifies the key health threats that the UK faces, and outlines how UKHSA will use science to mitigate these threats. The strategy is ambitious, but it is also achievable, and it has the potential to make a real difference to the health of the nation. The strategy is based on the following key principles:•Science-led: The strategy is based on sound scientific evidence, and it will be implemented through a rigorous scientific process.•Collaborative: The strategy will be implemented through collaboration with a wide range of partners, including academia, industry, and the public.•Innovative: The strategy will embrace innovation and new technologies, and it will support the development of new scientific solutions to health threats.•Efficient: The strategy will be implemented in an efficient and cost-effective manner.
Differential expression of CGNL1 in cancer of the skin: malignant melanoma.
Authors: Mamoor Shahan
Published: May 2023

Skin cancer is diagnosed in nearly 1.5 million patients each year (1). While patients with basal and squamous cell carcinomas are provided with 5-year survival rates at nearly 100% and 90%, respectively, patients diagnosed with cutaneous melanoma (metastatic melanoma) are provided 5-year survival rates at 91.4% at stage I and 24.6% at stage IV (2-5). We mined published and public microarray datasets (6, 7), using both primary tumor tissues and cultured tumor cell lines to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with the deadliest type of skin cancer, malignant melanoma. We found significant differential expression of the gene encoding cingulin-like 1, CGNL1, when comparing melanoma tissues and cells to non-transformed tissues and cells. CGNL1 mRNA was present at significantly lower quantities in melanoma tissues as compared to nevus. Analysis of human survival data revealed that expression of CGNL1 in the tumors of patients with melanoma was not correlated with overall survival. CGNL1 expression changes may be important for the initiation or progression of malignant melanoma in humans.
How to design and establish a national school-based physical fitness monitoring and surveillance system for children and adolescents: The ten-step approach recommended by the FitBack network
Authors: Joensuu Laura , Csányi Tamás , Huhtiniemi Mikko , Kälbi Katalin , Magalhães João , Milanović Ivana , Morrison Shawnda A , Ortega Francisco B. , Sardinha Luís B , Starc Gregor , Tammelin Tuija H , Jurak Gregor
Published: May 2023

Providing individual- and population-level data on child physical fitness is a crucial public health and education priority, however, few national fitness monitoring, or surveillance systems are currently in practice globally. The FitBack network includes experts from diverse backgrounds with a common interest to improving the accessibility of physical fitness monitoring and surveillance amongst school-aged children. This paper details findings of the FitBack network; descriptions of eight national or regional European physical fitness monitoring and surveillance systems, and experience-based ten-step guidelines for establishing one’s own system. Fitness monitoring and surveillance systems can successfully be implemented within school-settings, designed to meet the specific needs of a given region, and inform public health policies to reduce future disease burden. Monitoring systems connect to school-settings by teaching and advocating for physical literacy - a key component to maintaining a lifelong active, healthy lifestyle.
Salt‑rich versus salt‑poor structural scenarios in the central Northern Calcareous Alps: implications for the Hallstatt facies and early Alpine tectonic evolution (Eastern Alps, Austria)
Authors: Fernandez Oscar , Ortner Hugo , Sanders Diethard , Grasemann Bernhard , Leitner Thomas
Published: May 2023

One of the most remarkable features of the central Northern Calcareous Alps (Eastern Alps, Austria) is the widespread presence of Upper Triassic deep-water carbonates (the Hallstatt facies) and Permo-Triassic evaporites resting on deep-water Middle Jurassic strata and their underlying Upper Triassic shallow-water carbonate platform successions. The Hallstatt facies and accompanying evaporites have been classically interpreted to originate either from a location south of the time-equivalent carbonate platforms, or to have been deposited in deeper water seaways within the broad platform domain. To date, this dispute has been addressed mostly through the analysis of Triassic and Jurassic facies distribution in map view, which, however, is subject to some degree of ambiguity and subjectivity. In this contribution we present, for the first time, sequentially restored regional cross-sections through the central Northern Calcareous Alps to understand the implications of the contrasting paleogeographic models. We present (a) an interpretation based on a highly allochthonous origin of the Triassic deep-water units and (b) an interpretation based on their relative autochthony in which we incorporate the potential influence of salt tectonics in the central NCA. The restored cross-sections provide a framework within which the alternative scenarios and their paleogeographic implications can be better understood. Through this analysis we propose that salt tectonics in the central NCA can provide a valid explanation for apparent inconsistencies in the relative autochthony scenario and thus constitutes a reasonable alternative to the currently accepted allochthony scenario.
The role of thermal notch erosion in forcing localised calving failure and short-term increases in velocity at a lake-terminating glacier in southeast Iceland
Authors: Baurley Nathaniel , Hart Jane
Published: May 2023

We utilised repeat high-resolution UAV-SfM surveys, alongside terrestrial photography acquired in-situ, to investigate, for the first time, the role of thermal notch erosion in forcing localised calving failure and subsequent short-term increases in velocity at a lake-terminating glacier. This data was acquired daily (where possible) across one week in July 2019 and two weeks in July 2021 to provide insights into a suite of processes that are presently under-studied. We demonstrate that high-magnitude calving (surface area >1000 m2), occurring as a direct result of thermal notches at the waterline, can drive short-term increases in velocity up to 30% above the average, which are sustained for several days and occur over a much larger area of the glacier than was originally impacted by the initial calving event. We suggest that these findings present an important, yet previously undocumented aspect of the dynamic behaviour and overall stability of both freshwater and tidewater glaciers, warranting further research into these key processes.
Chasing the water table: The impact of groundwater depletion on rural drinking water supply in peninsular India
Authors: Srinivasan Veena , NR Lakshmikanta , G Manjunatha , Shinde Ganesh
Published: May 2023

Groundwater overexploitation has been cited as one of the biggest threats to rural drinking water in India, but there is very little quantitative evidence. In this paper, we aim to understand (1) the extent of actual groundwater depletion and its impact on rural drinking water supply systems, (2) the primary driver of groundwater depletion and (3) the additional financial burden in finding new sources for water supply and increased O&M costs.We rely on temporal data from two Gram Panchayats (local administrative unit) near Bengaluru, in south India. Our study results confirm that groundwater depletion, in this hard rock aquifer region, is a severe problem, driven largely by agricultural water abstraction. Rural drinking water supply systems have had to catch up continuously with the falling water table, abandoning non-functional wells and drilling new borewells to replace them. This has resulted in a major financial burden to the Gram Panchayats both in terms of increased capital and O&M costs. Increased pumping costs associated with declining groundwater levels impose a major burden on these Gram Panchayats, which are severely in “electricity debt”. Hitherto, state and central government grants have paid for rural well installation in India, but these schemes are time bound, posing a threat to future drinking water security.
Racial Bias in School Discipline and Police Contact: Evidence from the Adolescent Brain Cognitive Development Social Development (ABCD-SD) Study
Authors: Brislin Sarah J , Choi Maia , Perkins Emily R. , Ahonen Lia , McCoy Henrika , Boxer Paul , Clark Duncan , Jackson Dylan , Hicks Brian M.
Published: May 2023

AbstractObjective: Black youth are disproportionately exposed to school exclusionary discipline. We examined the impact of race on age at the onset of school disciplinary actions and police contact, and the rate of receiving increasingly severe disciplinary actions.Method: Youth (N = 2,156) and their caregivers participating in the Adolescent Brain Cognitive Development Social Development (ABCD-SD) study reported on the occurrence and timing of disciplinary events, the youth’s demographics, delinquency, and their neighborhood conditions. Experiences of exclusionary discipline were analyzed using logistic regression and Cox proportional hazard models.Results: Black youth reported significantly higher rates of almost all disciplinary events compared to White youth. In logistic regression and Cox models, Black youth experienced higher risk for exclusionary discipline and police contact (odds ratios from 2.47 [detention] to 5.16 [sent home]; hazard ratios from 1.36 [detention] to 4.71 [expelled]), even after adjusting for sex, delinquency, neighborhood conditions, and the interaction between race and sex. Black youth who received detention and suspension were at higher risk for additional, more severe school discipline than White youth. Conclusion: Consistent with a racial bias in exclusionary discipline practices and policing, Black youth, particularly Black males, were at a higher risk for experiencing almost all disciplinary outcomes and at younger ages than White youth, after controlling for delinquency, sex, and neighborhood factors. Compared to White students, school detention and suspension status predicted an accelerated cascade of school discipline outcomes for Black students, suggesting racial disparities in how the severity of school discipline escalates over time.
Meaning creation in novel noun-noun compounds: humans and language models
Authors: Chen Phoebe , Poeppel David , Zuanazzi Arianna
Published: May 2023

The interpretation of novel noun-noun compounds (NNCs, e.g., “devil salary”) requires the combination of nouns in the absence of syntactic cues, an interesting facet of complex meaning creation. Here we examine unconstrained interpretations of a large set of novel NNCs, to investigate how NNC constituents are combined into novel complex meanings. The data show that words’ lexical-semantic features (e.g., material, agentivity, imageability, semantic similarity) differentially contribute to the grammatical relations and the semantics of NNC interpretations. Further, we demonstrate that passive interpretations incur higher processing cost (longer interpretation times and more eye-movements) than active interpretations. Finally, we show that large language models (GPT-2, BERT, RoBERTa) can predict whether a NNC is interpretable by human participants and estimate differences in processing cost, but do not exhibit sensitivity to more subtle grammatical differences. The experiments illuminate how humans can use lexical-semantic features to interpret NNCs in the absence of explicit syntactic information.
Resting state functional connectivity in dependent cannabis users: the moderating role of cannabis attitudes
Authors: Kroon Emese , Toenders Yara , Kuhns Lauren , Cousijn Janna , Filbey Francesca
Published: May 2023

Background. The global increase in lenient cannabis policy has been paralleled by reduced harm perception, which has been associated with cannabis use initiation and persistent use. However, it is unclear how cultural attitudes towards cannabis use might affect the brain processes underlying cannabis use. Methods. Resting state functional connectivity (RSFC) within and between the executive control network, salience network, and default mode network was assessed in 110 near-daily dependent cannabis users and 79 controls from The Netherlands and Texas, USA. Participants completed a questionnaire assessing the perceived benefits and harms of cannabis use from their personal, friends-family’s and country-state’s perspective and reported on their cannabis use (gram/week), DSM-5 cannabis use disorder (CUD) symptoms, and cannabis related problems. Results. RSFC within the dorsal salience network was lower in cannabis users than controls and was negatively associated with cannabis use in the cannabis group. Cultural attitudes – from personal, friends-family’s and country-state’s perspectives – moderated the associations of cannabis use, CUD symptoms, and cannabis use related problems with RSFC within the salience, executive control, and default mode networks. No group differences in between-network RSFC were observed, but personal perceived benefits and country-state perceived harms moderated the association between CUD symptoms and RSFC between the dorsal and ventral default mode network. Conclusions. This study highlights the importance of considering individual differences in the perceived harms and benefits of cannabis use as a factor in the associations between brain functioning and cannabis use, CUD symptoms, and cannabis use related problems.
Humans do not avoid reactively implementing cognitive control
Authors: Bustos Bettina , Colvett Jackson Stuart , Bugg Julie , Kool Wouter
Published: May 2023

The ability to exert cognitive control allows us to achieve goals in the face of distraction and competing actions. However, control is costly, and therefore people generally aim to minimize control demands. Because control takes many forms, it is important to understand whether such costs apply universally. Specifically, reactive control, which is recruited in response to contextual features, is theorized to be deployed automatically, and not depend on attentional resources. Here, we investigated whether people avoided implementing reactive control in three experiments. In all, participants performed a Stroop task in which certain items were mostly incongruent, i.e., associated with a high likelihood of conflict (triggering a focused control setting). Other items were mostly congruent, i.e., associated with a low likelihood of conflict (triggering a relaxed control setting). Experiment 1 demonstrated that these control settings transfer to a subsequent unbiased transfer phase. In Experiments 2-3, we used a Demand Selection Task (DST) to investigate whether people would avoid choice options that yielded items that were previously mostly incongruent (MI). In all, participants continued to retrieve focused control settings for previously MI items, but they did not avoid them in the DST. Critically, we only found demand avoidance when there was an objective difference in demand between options. These findings are consistent with the idea that implementing reactive control does not register as costly.
How Robust are Country Rankings in Educational Mobility?
Authors: Strömberg Ely , Engzell Per
Published: May 2023

As robustness of social science is getting more attention, analytical choices have turned out to be more important than previously thought. In this paper, we investigate the robustness of intergenerational educational mobility estimates using multiverse analysis, a technique for incorporating many analyses into one framework while varying analytical choices such as variable coding, mobility measures, and exclusion criteria. Using European Social Survey (ESS) data from 16 European countries, results show substantial variation, both in point estimates and rank orderings among countries. Even so, the central tendency of country ranks accords well with previous literature. While any single ranking comes with considerable uncertainty, the field has nevertheless produced a relatively robust set of empirical findings.
PERAN MODERASI SALES GROWTH DAN LEVERAGE TERHADAP UKURAN DAN KINERJA PERUSAHAAN
Authors: Oktavini Eva , Tampubolon Lambok DR , Amelinda Rita , Mannuela Anwar Roseline
Published: May 2023

Penelitian ini bertujuan untuk menguji pengaruh ukuran perusahaan terhadap kinerja perusahaan dengan peran pertumbuhan penjualan sebagai moderasi. Populasi pada penelitian ini adalah perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia pada periode 2017 – 2019 dengan total sampel sebanyak 180. Analisa yang digunakan dalam penelitian adalah regresi linear berganda. Hasil dari penelitian ini menunjukkan bahwa ukuran perusahaan berpengaruh positif terhadap kinerja perusahaan sedangkan peran moderasi sales growth dan leverage terbukti tidak berpengaruh.
The Influence of Perceived Value and Brand Experience on Purchasing Decisions of YouTube Premium Services (Study on Followers Instagram Account @Youtuber Karawang)
Authors: Fatikha sari Risha , Musadad Anwar
Published: May 2023

The study entitled " Influence Perceived Value and Brand Experience Against Purchasing Decisions YouTube Premium Service ” . aim for know influence variable Perceived Value and Brand Experience towards Purchase Decision . Population selected  is follower account Instagram @YoutuberKarawang with total population as much 3700 people and from results calculation formula Isaac and Michael obtained total sample which must collected is as many as 348 people. Approach which used is quantitative, with method descriptive verification , and technique analysis path.After conducted study obtained results that Perceived values, Brands experiences, and Decision Purchase entirely get results end which good. Next results test Q variable Perceived Value (X1) and Brands Experience (X2) each own influence positive and significant in a manner Partial to variable Decision Purchase (Y). Likewise with the test results ANOVA or F test obtained results that variable Perceived Value (X1) and Brands Experience (X2) in a manner simultaneous influential to variable Purchase Decision (Y).