bluuebunny/crossref_metadata_2025 huggingface dataset:
Accounting for the Central Role of Interfacial Water in Protein-Ligand Binding Free Energy Calculations
Authors: Ben-Shalom Ido , Lin Zhixiong , Radak Brian , Lin Charles , Sherman Woody , Gilson Michael K.
Published: July 2020

Rigorous binding free energy methods in drug discovery are growing in popularity due to a combination of methodological advances, improvements in computer hardware, and workflow automation. These calculations typically use molecular dynamics (MD) to sample from the Boltzmann distribution of conformational states. However, when part or all the binding site is inaccessible to bulk solvent, the time needed for water molecules to equilibrate between bulk solvent and the binding site can be well beyond what is practical with standard MD. This sampling limitation is problematic in relative binding free energy calculations, which compute the reversible work of converting Ligand 1 to Ligand 2 within the binding site. Thus, if Ligand 1 is smaller and/or more polar than Ligand 2, the perturbation may allow additional water molecules to occupy a region of the binding site. However, this change in hydration may not be captured by standard MD simulations and may therefore lead to errors in the computed free energy. We recently developed a hybrid Monte Carlo/MD (MC/MD) method, which speeds the equilibration of water between bulk solvent and buried cavities, while sampling from the intended distribution of states. Here, we report on the use of this approach in the context of alchemical binding free energy calculations. We find that using MC/MD markedly improves the accuracy of the calculations and also reduces hysteresis between the forward and reverse perturbations, relative to matched calculations using only MD with or without the crystallographic water molecules. The present method is available for use in the AMBER simulation software.
Does Tyrosine Protect S. Coelicolor Laccase from Oxidative Degradation?
Authors: Kielb Patrycja , Gray Harry B. , Winkler Jay R.
Published: July 2020

We have investigated the roles of tyrosine (Tyr) and tryptophan (Trp) residues in the four-electron reduction of oxygen catalyzed by Streptomyces coelicolor laccase (SLAC). During normal enzymatic turnover in laccases, reducing equivalents are delivered to a type 1 Cu center (CuT1) and then are transferred over 13 Å to a trinuclear Cu site (TNC: (CuT3)2CuT2) where O2 reduction occurs. The TNC in SLAC is surrounded by a large cluster of Tyr and Trp residues that can provide reducing equivalents when the normal flow of electrons is disrupted. Canters and coworkers have shown that when O2 reacts with a reduced SLAC variant lacking the CuT1 center, a Tyr108· radical near the TNC forms rapidly. We have found that ascorbate reduces the Tyr108· radical in wild-type SLAC about 10 times faster than it reacts with the CuT12+ center, possibly owing to radical transfer along a Tyr/Trp chain. Aerobic oxidation of two reduced SLAC mutants (Y108F and W132F) leads to the formation of a long-lived (~15 min) Tyr· radical with distinct absorption at 408 nm. The diffusion of redox equivalents away from the primary enzymatic pathway in SLAC may indicate a poorly optimized enzyme or a mechanism to protect against protein damage.
A Three Component-Based Van Der Waals Surface Vertically Designed for Biomolecular Recognition Enhancement
Authors: Hassan Ayaz , Macedo Lucyano , Mattioli Isabela A. , Rubira Rafael J. G. , Constantino Carlos J. L. , G. Amorim Rodrigo , Lima Filipe , Crespilho Frank
Published: July 2020

Graphene-based vertical electrodes may have applications in biomolecular recognition for producing low-cost biodevices with high electronic conductivity. However, they are unsuitable for measuring small interfacial capacitance variations because graphene is mostly composed of basal sp2 carbon surface, which limits its sensitivity as an electrochemical biosensor. Herein, we introduce an unconventional device alternative based on a three-component vertically designed (TCVD) surface comprising ferrocene/graphene/gold deposited on SiO2/Si wafers. Ferrocene is the top layer that promotes reversible redox communication with the electrolyte, while graphene–gold is the strategically projected layer underneath. Bader charge analysis indicated that graphene donates electronic density to the gold surface, thereby significantly increases the charge transfer exchange rate with ferrocene. The TCVD surface is much more reactive and sensitive to charge variations compared with pristine graphene, and it maintains excellent conductive properties. The TCVD device was used to detect DNA hybridization in solutions, since this is well-known to be a challenging process on a pristine graphene vertical device. A TCVD device can detect small interfacial charge perturbations from DNA hybridization. Based on quantum mechanics calculations combined with spectromicroscopy data, it was realized that the unique synergic interaction between gold and graphene amplified biomolecular recognition, whereby DNA in nanomolar range concentration correlated to 0.8 ± 0.1 µF cm-2, which was effortlessly detected. This result is promising since 3.0 µF cm-2 is the limit of quantum capacitance for bare graphene. Notably, these results open a new possibility for next-generation TCVD bioelectronics based on van der Waals surfaces, while further innovation and material scrutiny may lead to the achievement of TCVD devices with robust biomolecular recognition abilities.
A Comprehensive Review on Antiulcer properties of Herbal drugs
Authors: Sayed Al Ansary  , Jyothi Y  , Rajendra Sandur V
Published: July 2020

Herbal medicines are very useful in treating various human ailments. The plants and herbs consumed in its natural state have proved to have lesser side effects and are cost effective too. Recognition of this fact has created a demand for herbal medicines, both in developing and developed countries across the globe. Peptic ulcer disease in clinical practice is one of the common gastrointestinal disorders where duodenal ulcer, gastric ulcer, NSAIDs triggered ulcer and stress ulcer are common forms of peptic ulcer. Gastric ulcers are commonly found in the geriatrics and in the lower socio-economic class of people. Most synthetic drugs are used to treat peptic ulcers, but they cause adverse effects of various kinds. For its ethnic, ethno botanical and ethno pharmacological use, herbal medicines are therefore exceptional. In this review, attempts were made to know the natural antiulcer drugs with their recommended drug portion, screening method and sort of extract used for appraisal and observations to show its usage. The reason for this assessment is to assemble literature and the antiulcer residences of the herbal medicines used frequently. Different plants such as Allium sativum, Centella asiatica, Lawsonia inermis, Ocimum sanctum, Sesbania grandiflora, Adansonia digitata, Ficus religiosa, Glycyrrhiza glabra, Cynodon dactylon, have been shown to be involved in antiulcer care.
A questionnaire study on knowledge and awareness of metabolic syndrome and it’s components in undergraduate medical students at entry level
Authors: Soundarya Vemuri  , Krishna Veni D V  , Chigulapalli Neha  , Sravya Reddy
Published: July 2020

Metabolic syndrome is a major and escalating public health crisis among young adults in recent times. Increasing calorie intake, sedentary lifestyle, lack of exercise and chronic stress are the contributing factors for metabolic syndrome. The objective of this study is to evaluate the awareness and knowledge levels of first-year medical students regarding various aspects in metabolic syndrome. The study was conducted among 74 undergraduate medical students at Apollo institute of medical sciences and research. A standardized questionnaire was given to the students and the students were asked to answer the questionnaire independently and the responses obtained were statistically analyzed. In our study, the participants showed a good level of knowledge about different types, the pattern of inheritance and symptoms of diabetes mellitus. They were cognizant about causes, risk factors and treatment of adiposity and hypertension. The majority knew about ill effects of high cholesterol, stroke and arteriosclerosis. Most of them doesn’t know the underlying mechanism of heart infraction. The study also identified areas of deficiencies in the knowledge of students about different components of metabolic syndrome. This effort is done in the beginning of their course because being the force of future medical feternity, they can educate themselves and the public about ill-effects of metabolic syndrome and means to prevent it as a part of public health. The study also supports the necessity of early clinical exposure for medical students at the entry-level.
A promising method to enhance the solubility of poorly water soluble drug by using hot-melt extrusion technique
Authors: Kavinkumar Sakthivel  , Krishnanand Anilkumar  , Jawahar Natarajan  , Senthil Venkatachalam
Published: July 2020

More than 40% of new chemicals are of poor solubility, it causes poor bioavailability. Several techniques are available to increase the solubility of drugs, such as converting the drug into salt form, complexion, co-solvency, particle size reduction, nano-suspension, cryogenic technique, modification of crystal habit etc. Hot melt extrusion has increased wide acknowledgment in the recent past. Over the past recent three decades modern flexibility has permitted hot melt extrusion (HME) is to increase wide acknowledgment and has just settled its place in the wide range of assembling activities and pharmaceutical research advancements. HME has just been exhibited as a vigorous, novel system to cause strong scatterings so as to give time controlled, changed, broadened, and focused on medicate conveyance bringing about improved bioavailability just as taste covering of bitter Active Pharmaceutical Ingredients (APIs). Hot melt extrusion is one of the efficient technique for improving the solubility of hydrophobic drugs by forming solid dispersion. It is a solventfree process and time taken for the production is less. The process involved in this technique include, weighing/feeding, Melting, Mixing, Venting, Extrusion, Cooling, Pelletizing. Solubility of many drugs have improved by utilizing hot melt-extrusion technology. In this review, a detailed overview about Solubility enhancement of drugs by hot-melt extrusion and its applications are discussed. This review summarizes the importance and uses of solid dispersion technique for improving the solubility of poorly soluble drugs
Impact of community based awareness education about dengue by assessing knowledge and preventive practices in rural population
Authors: Komal Meshram  , Ajay Meshram  , Shubham Chopra  , Ujwal Gajbe
Published: July 2020

Dengue a major international public health concern is a vector-borne viral infection caused due to bite of Aedes aegypti mosquito. To reduce humanmosquito contact or eliminate vector population efforts should be made. The knowledge gained through this investigation would help rural population to take certain preventive and control measures against dengue fever. It would also be helpful to guide policy makers and health authorities to plan, design and initiate initiatives, various programs and policies regarding prevention of dengue. To find out the impact of community-based awareness education about dengue by assessing knowledge and preventive practices in rural population. A Cross-sectional questionnaire-based study was done in rural population residing near the Datta Meghe Medical College, Wanadongri, Nagpur over a period of three months. Sample size of 166 participants; age more than 18 years residing in rural area were included in the study. Positive correlation in knowledge regarding dengue fever was found at post test among participants and information imparted; significant improvement was observed with respect to pretest taken. Questionnaire helped individuals to gain more knowledge regarding the disease and its prevention. This study concludes that the knowledge score of participants regarding dengue fever and invigilator increases at post test. Hence a better and healthy community can be achieved just by imparting simple doorstep knowledge.
A Case Report of Recurrent unilateral Bell’s Palsy in young female
Authors: Khlood Mohammad Aldossary
Published: July 2020

Most facial palsies comprise of lower motor neuron type or Bell’s palsy. The mean incidence of recurrence of Bell’s palsy is 6.5% and can recur at any age. Although it was first reported in the year 1871, most of its etiology, pathology, management and progression are still neither fully described nor reported. We reported a case of Bell’s palsy in a young Saudi female who was presented with a unilateral recurrent episode of Bell’s palsy. Patient came to the emergency department with facial asymmetry, severe neck pain, loss of sensation on the left side of face and headache, while she was also not responding to oral medications. She was admitted to the hospital for an intravenous treatment and for further evaluation. Her serologic investigation was unremarkable. Similar episode had occurred five years ago as well, which was completely resolved after treatment. Her brain MRI localized T2 and T2 weighted sequence showed hyperintense lesion at the superior anterior aspect of left orbit and could represent lipoma versus hemangioma. Her presenting complaint responded well on IV treatment and patient was discharged on 11th day. She was also referred for plastic and neurosurgery services for the treatment of underlying cause. Recurrent Bell’s palsy is infrequent with etiology not fully elucidated. However, our case emphasizes that the timely medical treatment with regular follow-up is necessary for better prognosis and identification and treatment of underlying cause.
四联疗法联合胃复春在慢性萎缩性胃炎治疗中的效果观察
Authors: 肖 作凌
Published: July 2020

目的： 主要对于慢性萎缩性胃炎实施四联疗法以及胃复春结合治疗，对其效果进行探讨。 方法： 选择 2018 年 1 月至 2019 年1 月在我院消化内科进行诊断以及收治的此类疾病患者 100 例，采用平均以及随机的方法进行分组，观察组的患者为 50 例，对照组的患者为 50 例。关于对照组的患者主要实施四联疗法进行治疗 ; 关于观察组的患者除了使用四联疗法之外，还会利用胃复春药物实施治疗，治疗满一年之后，进行胃镜检查，分别对这些患者实施比较。 结果： 在一年之后，该试验当中的所有患者的临床症状都有了一定程度的改善。重复胃镜检查之后，发现观察组当中治愈的患者为 11 例，显效的患者为 19 例，有17 例患者有效，有 3 例患者无效，总有效率可以达到 94％，和对照组相比较要高很多，统计学意义比较明显，P<0.05。 结论：关于萎缩性胃炎的治疗当中，可以使用四联疗法以及胃复春疗法进行结合，这样可以使得 Hp 感染得到有效的根除，改善临床上的相关症状，值得在后续的治疗中进行使用。
不同的全身麻醉方法对腹腔镜下胆囊切除术后早期认知功能的影响
Authors: 花 震东
Published: July 2020

目的： 观察不同全身麻醉方法对腹腔镜下行胆囊切除术的患者的术后早期认知功能的影响。 方法： 随机选取我院 2016 年 2 月至 2018 年 12 月期间接收的 70 例腹腔镜下行胆囊切除术患者为研究对象，根据麻醉方式的不同，将其分为观察组（n=35）与对照组（n=35）。其中，对照组患者进行全程吸入麻醉，观察组患者实施全凭静脉麻醉。对比两组患者在术后 24h 以及术后 72h 的认知能力。 结果： 认知能力调查结果显示，术后 24h 两组患者均出现了一定程度的认知功能障碍（P ＞ 0.05）；术后 72h 观察组患者的认知功能基本恢复术前水平，与对照组相比，存在显著统计学差异，P ＜ 0.05。 结论： 在对腹腔镜下行胆囊切除术患者进行麻醉处置时，与全程吸入麻醉方式相比，全凭静脉麻醉对患者术后早期认知功能的影响更小，提示此种麻醉方式对患者的术后恢复有积极作用。
应用外固定器治疗临床骨科的疗效
Authors: 汪 洋 , 刘 旸
Published: July 2020

骨折是骨科中最为常见的疾病之一，治疗难度相对较大。如果不及时进行治疗会导致患者并发症的发生概率大大增加，而且会造成骨折愈合难度增大，影响患者的正常康复。外固定器是当前临床骨科治疗过程中应用最为广泛的一种治疗方式，可以有效固定骨折的部位，加快患者的康复进程。论文主要针对外固定器在治疗临床骨科中的临床效果进行探究。
Interrogating the Nexus between Party Politics and Party Institutionalization in Nigeria
Authors: Alfa Patrick Innocent
Published: July 2020

This article critically examines the nature of party politics in Nigeria since the inception of the Fourth Republic. It contends that party politics in Nigeria's Fourth Republic is characterised by dysfunctional evolution of political parties, lack of unity and focus, electoral fraud, lack of internal party democracy, intergovernmental disharmony, political violence, ideological deficit, gross indiscipline and elite antagonism. The article is methodologically conceptual. Relevant secondary data comprising of journal articles, textbooks, workshop papers, and national dailies were consulted. The article discovered that party politics in Nigeria's Fourth Republic is highly defective and volatile, thus forestalling party institutionalization and, by extension, democratic stability. The article concludes with recommendations on how Nigeria's party politics could be redefined to facilitate party institutionalization and improve the quality of democratic  governance
Гібридна війна: сутність та структура феномену
Authors: Komarchuk Oleksandr
Published: July 2020

Відзначається, що агресія з боку Російської Федерації стала суттєвою несподіванкою для українського суспільства, а сучасний російсько-український конфлікт має офіційний статус АТО, але, на жаль, це єдина можливість охарактеризувати «гібридну війну» на правовому рівні.

Аналізуючи ступінь наукової розробки дослідження проблеми, констатуємо, що загалом у політичній науці обмаль наукових розвідок щодо поняття «гібридна війна». Застосовуючи системний та історичний підходи до аналізу поняття «гібридна війна», наголошено на необхідності  комплексного підходу до вивчення зазначеного явища. Указано, що для вирішення конфліктних питань або задоволення геополітичних інтересів виступати відкрито для держави-агресора стало досить невигідним в економічному та небезпечним у політичному плані, тому наприкінці XX ст. людство зіткнулося з новим способом ведення збройних конфліктів, що отримало неофіційну назву «гібридною». Цей термін пояснює нову військову стратегію, яка поєднує в собі «звичайну війну», «малу війну» та «кібервійну» і служить для поєднання дій із залученням ядерної, біологічної, хімічної зброї та засобів інформаційної війни.

Застосовуючи сучасні підходи до вивчення феномену «гібридної війни», інтерпретуємо це явище як сукупність заздалегідь підготовлених та оперативно реалізованих державою дій військового, дипломатичного та інформаційного характеру, спрямованих на досягнення стратегічних цілей. При цьому важливе значення має відсутність необхідності в розробці нових систем зброї й військової техніки. Гібридна війна включає реалізацію комплексу гібридних загроз різного виду, а саме: традиційні, нестандартні, масштабний тероризм, а також підривні дії, у ході яких використовують інноваційні технології для протидії військовій силі супротивника, такі як масовані кібератаки, підривні дії в енергетичній, економічній сферах тощо.

Зазначено, що відмінність між класичними війнами та гібридними полягає не лише в способі їх ведення, а й у засобах та цілях, які переслідує агресор, оскільки метою «гібридної війни» є не контроль території, а економічна та політична дестабілізація держави, тримання в страху населення в цілому, яке проживає за межами безпосереднього конфлікту. Дестабілізація країни в усіх цих аспектах удається завдяки терористичним і диверсійним актам, активній пропаганді серед місцевого населення, ведення повномасштабних бойових дій на певній території країни, а кінцевою метою є схилення легального уряду країни до вигідних для агресора дій або його зміни. Усі вищевказані етапи підготовки та реалізації військових дій неможливі без участі засобів масової комунікації, які безпосередньо є  технологічним інструментом організації та проведення  «гібридних війн».
ENERGY CONSUMPTION AND UTILITY PRACTICES IN INDIA: AN EMPIRICAL ANALYSIS
Authors: GANESAMURTHY Dr. K. , MORARJI Dr. A. , SHANMUGA PRIYA Mrs. N.
Published: July 2020

In India, the sources of energy availability to the human development has been advocated since independence, so much so that the adequate quantity and quality of electricity, and measured by per capita consumption, is associated in most economies as a key Human Development Index. It is expected that the nation, which is already in the forefront of urbanization and industrialization in the country, proposes to be a global hub of manufacturing. Such a vision, if continued by successive governments, will leads to a scenario where the demand for electricity is most likely to increase year after year for decades. This Paper attempts to identify the sources of electrical energy in India. The growth of agriculture, manufacturing and service sectors has been possible to modify the energy in every year and also utilization of new technologies in their production. As a result, the electrical energy is leads to greater importance for agriculture and farmers have better control over the availability of energy for productive oriented. Based on the utilization of the energy the audit reports of various departments such as agriculture, corporate and Government etc., and electric utilities are some time at variance in all field. This paper highlights the need for the electricity and strategy for optimum utilization of resource like electrical energy and renewable energy in India and it’s bringing into the plan of action to the corporate and government in India for sustainability.
INFLUENCIA DE ADITIVOS (POLÍMEROS Y POLIALUMINIO) EN LAS PROPIEDADES FÍSICO-MECÁNICAS DE MEZCLAS ASFÁLTICAS EN CALIENTE
Authors: León Torres Paul Javier , Maila Paucar Jorge Humberto , Albuja Córdova Efrén Wladimir
Published: July 2020

A nivel mundial se ha emprendido el uso de aditivos a fin de tener mezclas asfálticas de mejor calidad y que permitan disminuir el envejecimiento prematuro de las mismas, en nuestro país se requiere investigaciones que sean ejecutadas con distintos agregados pétreos y comparar el comportamiento del ligante empleado y de las mezclas propiamente dichas, por lo que este trabajo es científicamente necesario que no sea el único si no que se emprenda más investigaciones y usar distintas fuentes de materiales solo así podremos tener información y datos comparativos para la toma de decisiones en el campo de construcción de carpetas asfálticas. La investigación consiste en realizar un análisis comparativo de la influencia de los aditivos en las propiedades físico-mecánicas en las mezclas asfálticas en caliente. Se recopilo información de 3 proyectos de investigación de mezclas asfálticas modificadas con polímero SBS, RET, SBR y polialuminio, donde el Laboratorio de Pavimentos brindo apoyo en ensayos para el desarrollo de las mismas. Proyecto N° 1: Agregados provenientes de Pifo con incorporación de polímero SBS y RET; Proyecto N° 2: Agregados provenientes de Nayón con incorporación de polímero SBS y SBR y Proyecto N° 3: Agregados de dos minas Píntag y Guayllabamba con incorporación de polialuminio. Con cuyos datos se analiza las mejoras que se obtiene con la incorporación de aditivos en mezclas asfálticas convencionales, respecto a las características resistentes relacionadas con la deformación plástica a través de la determinación de estabilidad y flujo (ensayo Marshall) y el valor de pérdida por desgaste (ensayo Cántabro). Demostrando que al añadir cantidades optimas de los aditivos antes mencionados mejora las propiedades mecánicas aumenta la estabilidad y disminuye el porcentaje de perdida por desgaste al cántabro, esto quiere decir que aumenta la cohesión de la mezcla disminuyendo el riesgo de deformación permanente (ahuellamiento) y fisuramiento, mejorando la elasticidad, aportando así en la durabilidad de la vida útil de las vías del país.
Marcos históricos que permeiam a saúde pública brasileira: perspectiva de 1950 até 2019
Authors: Carvalho Leandro Rodrigues de Oliveira , Rodrigues Hellbia Samara Moreira de Carvalho , Da Rosa Chennyfer Dobbins Paes
Published: July 2020

O sistema de saúde pública brasileiro visa promover o direito de acesso as ações e serviços em saúde, garantidos pelo poder público através do Sistema Único de Saúde (SUS), válido em todo território nacional. O objetivo deste trabalho foi reunir uma revisão de literatura sobre o tema: Histórico e desenvolvimento do SUS desde os primórdios de sua criação até os dias atuais, e os fatores socioeconômicos, políticos e culturais que influenciaram em seus termos decisórios. Para dai produzir a linha do tempo em um recorte temporal desde a década de 1950, marcada com os principais fatos históricos, seguindo um passo cronológico e evolutivo do SUS. O presente trabalho tem como pressupostos metodológicos a pesquisa exploratória desenvolvida por meio de uma revisão bibliográfica e documental, de natureza qualitativa, dando ênfase à literatura científica sobre a construção do SUS, para tanto, utilizou artigos científicos de periódicos, e estudos do Governo Federal e Leis sobre o tema. Tais dados foram compilados das fontes digitais de interesse público. Contudo, a revisão de literatura foi válida para prover conhecimento acerca da temática, e possibilitou unir em um trabalho os aspectos gerais sobre o histórico do SUS, e produção da linha do tempo caracterizada pelo seu desenvolvimento, linha esta que pode instrumentalizar a didática para ensino ao esboçar estes marcos históricos.
Conhecimento, atitude e prática: conceitos e desafios na área de educação e saúde
Authors: Chariglione Isabelle Patriciá Freitas Soares
Published: July 2020

Objetivo: Realizar uma análise crítica sobre a utilidade e o valor dos inquéritos que o método Pesquisa de Conhecimento, Atitude e Prática (CAP). Fontes de dados: Foram utilizadas as bases de dados MEDLINE/PubMed, ScienceDirect Journals, Elsevier e Oxford Journals. Após os critérios de inclusão e exclusão foram analisados e discutidos 16 estudos publicados nos últimos 10 anos. Resultados: Síntese dos dados: Os estudos CAP foram usados para fins de diagnóstico e ​​como ferramenta de planejamento e avaliação de intervenções de saúde. O método mostrou-se com maior aplicação nos estudos de corte transversal e com abordagem quantitativa. Observou-se variabilidade entre os estudos quanto a padronização metodológica e ao uso do método. Conclusão: Evidencia-se a necessidade do fortalecimento das principais questões relacionadas ao inquérito CAP como uma ferramenta importante na avaliação das percepções das pessoas, vontade e capacidade de investir e participar de certas práticas e programas na área da saúde.
Uso da posição prona nos pacientes com Síndrome do Desconforto Respiratório do Adulto
Authors: PARRY DENIS CARVALHO , GAUDARD ANA MARCIA IUNES , Barbosa Paulo Victor Rabelo
Published: July 2020

Introdução: O uso da posição prona (PP) em pacientes com Síndrome do Desconforto Respiratório do Adulto (SDRA) já é uma evidencia descrita nas diretrizes clinicas nacionais e internacionais. Apesar da SDRA ser a causa comum de internação e óbitos nas Unidades de Terapia Intensiva parece que esta pratica não é amplamente adotada nesses serviços. Objetivo: Analisar as atuais evidências referentes ao uso da PP em pacientes com SDRA. Métodos: Realizamos uma  revisão integrativa  com  buscas nas bases de dados Bireme/Lilacs, Pub-med, Medline, Cochrane, Scielo, BVS, Dyname, EBSCP e Epscool, de 2013 a 2018. Conclusão: A prona pode ser fundamental nos casos graves. É primordial uma equipe capacitada e de boa infraestrutura

Palavras-chave:  Decúbito Ventral; Síndrome do desconforto respiratória do adulto; Cuidados Críticos; Hipóxia; Insuficiência Respiratória
Uso de Cosmecêuticos no Rejuvenescimento Facial
Authors: Nogueira Amaral Guerra Mariana , Santos Fonseca Ana Flávia , Rocha Sobrinho Hermínio Maurício
Published: July 2020

No Brasil ainda não há legislação sanitária contemplando o uso e comercialização de produtos cosmecêuticos. Os cosmecêuticos são produtos novos capazes de afetar a estrutura e fisiologia da pele. Objetivo: Descrever os principais tipos de cosmecêuticos empregados em tratamentos estéticos de rejuvenescimento cutâneo facial, destacando seus respectivos mecanismos de ação e efeitos biológicos, assim como as suas principais contraindicações e efeitos adversos. Método: Trata-se de uma revisão bibliográfica narrativa com pesquisa de estudos publicados no período de 2004 a 2019. Resultados: A pele humana sofre ação do tempo sendo afetada por fatores intrínsecos e extrínsecos. A identificação e tratamento do envelhecimento cutâneo precoce é fundamental para se evitar doenças dermatológicas e melhorar a aparência, autoestima e saúde. Uma das formas comprovadas de se estimular o rejuvenescimento da pele é a utilização de cosmecêuticos a partir de um regime de cuidados diários com a pele. Os cosmecêuticos são produtos capazes de corrigir danos da pele, repor elementos perdidos com o envelhecimento e ainda apresentam ação preventiva, sendo divididos em antioxidantes, alfa-hidroxilácidos, retinóides, entre outros. Podem ter ação oral, tópica ou conjunta, que prometem melhorar o aspecto facial, com um considerável custo-benefício. Conclusões: A associação do uso diário de cosmecêuticos com tratamentos estéticos tais como limpeza de pele, peelings químicos, tratamento de flacidez cutânea tem apresentado resultados promissores no processo de rejuvenescimento facial. O uso de cosmecêuticos com acompanhamento de um profissional e seguindo as recomendações adequadas, minimiza ou anula o risco de danos para a saúde do paciente.
Efetividade de um programa educativo-preventivo de saúde bucal em condições bucais entre escolares
Authors: Cunha Inara Pereira , De Farias Santos Fernanda Rodrigues , Silva-Junior Manoelito Ferreira , Batista Marília Jesus , De Souza Maria da Luz Rosário
Published: July 2020

Objetivo: O estudo buscou avaliar a efetividade de um programa educativo-preventivo para a melhoria das condições bucais entre escolares, de duas escolas públicas de Piracicaba/SP. Métodos: Trata-se de um estudo de intervenção, controlado. A amostra foi constituída por 213 crianças, distribuída entre uma escola do grupo teste (n=109) e do grupo controle (n=104). O programa teve duração de 18 meses (2013 a 2015). Foram realizadas atividades educativas e exames clínicos antes e após a intervenção. No baseline, houve a aplicação de questionários. Resultado: O grupo teste apresentou inicialmente índice de biofilme de 23,5 e ao final uma média de 18,7, no grupo controle a média inicial foi de 23,93 para 22,01 ao final do programa. Houve redução de superfícies com manchas brancas no grupo teste (p<0,01), mas não para o grupo controle (p=0,110). Para a condição gengival o grupo teste também apresentou melhora, com redução da prevalência (p<0,05). Conclusão: As estratégias do programa foram efetivas, podendo ser reproduzidas em outros grupos de escolares.
Conhecimento e práticas pedagógicas de docentes sobre o transtorno de déficit de atenção e hiperatividade (TDAH)
Authors: Cavalheiri Jolana Cristina
Published: July 2020

Objetivo: Identificar o conhecimento e as práticas pedagógicas exercidas pelos docentes do Ensino Fundamental I, na escolarização do aluno com TDAH, no município de Francisco Beltrão - PR. Métodos: Estudo exploratório, de campo e de caráter quantitativo, realizado com 99 docentes. A coleta de dados ocorreu nos meses de junho e julho por meio do preenchimento de questionários autorrespondidos, confeccionados pelas pesquisadoras conforme literatura pertinente, os quais tinham o objetivo de identificar o perfil dos profissionais, a estrutura física, pedagógica das escolas e o conhecimento dos docentes. Resultados: Nas variáveis dos conhecimentos dos professores, grande parte apresentou conhecimento insuficiente, quanto à etiologia, diagnóstico, tratamento e medicação. Enquanto no domínio que avaliava a sintomatologia de TDAH manifestadas pelos alunos, os professores demostraram um conhecimento adequado. Em relação às práticas pedagógicas, os docentes salientaram o emprego e a viabilidade de utilizar jogos educativos e materiais dourados. Conclusões: Os docentes apresentam conhecimentos insuficientes sobre o TDAH, e na maioria das vezes não adaptam suas práticas pedagógicas voltadas ao aluno com o transtorno, bem como, a equipe multidisciplinar não é totalmente efetiva nas escolas pesquisadas.
PROMOTING CULTURAL AWARENESS THROUGH INTERCULTURAL LISTENING ACTIVITIES
Authors: Hidayati Arini Nurul , Santiana Santiana
Published: July 2020

As diversity is one of heated issues emerging in English teaching learning circumstance in Indonesia, teachers have to initiate strategies to restrain the probability of fragment among the students which can furthermost impact on their ability to communicate among cultures. Intercultural listening activities conducted at a university in West Java has evidently proven its contribution in consolidating the students’ cultural awareness. Through reflective journals and focused-group interviews, it is found that the students are able to discover, understand, and compare their own culture and others, realize the similarities and differences, and respect the existing gaps in between. Thus, they are presumed to be more ready to take part in the intercultural communication
LISTENING STRATEGIES OF STUDENTS AT ENGLISH EDUCATION STUDY PROGRAM OF PATTIMURA UNIVERSITY AMBON; IMPLICATION FOR TEACHING LISTENING
Authors: Lewier Christian Albert , Nendissa Priska
Published: July 2020

The present study investigated the implementation of various strategies performed by Indonesian EFL learners.  Sixty students of English Education Study Program at Teachers Training and Educational Sciences Faculty of Pattimura University in Ambon were studied on their use of various listening strategies. The result of the study shows that most of these students applied social/affective strategies (76.6%) and metacognitive strategies (46.6%). The use of these strategies were favored by the students as listening strategy preferences due to their effectiveness in facilitating comprehension. The students’ perception on various strategies was identified and implication for teaching listening is further discussed in the article
Edukasi Nutrisi Remaja: Menghitung Kalori Minuman Kekinian
Authors: Meinarisa Meinarisa , Sanuddin Mukhlis , Husaini Ahmad
Published: July 2020

Masa sekarang ini, remaja merupakan tumpuan utama untuk menjaga penduduk indonesia tumbuh seimbang setelah tahun 2020. Pada masa mendatang, remaja saat ini adalah yang akan menjadi dewasa dan meneruskan perubahan dan pembangunan negara. Untuk itu remaja saat ini harus disiapkan untuk menjadi produktif dan berkualitas. Salah satu hal yang penting dalam mempersiapkan remaja menjadi generasi berkualitas dan produktif adalah dengan mempersiapkan gizi dan kebutuhan makan remaja. Banyak negara saat ini mengalami masalah dalam pengendalian obesitas terutama pada remaja. 34% anak-anak usia diatas 12 tahun mengalami obesitas. Berkembangnya industri makanan dan sosial media berdampak besar pada remaja. Remaja sebaiknya mengetahui diet sehat bagi remaja. Karena jenis makanan akan sangat menentukan kesehatan remaja. Banyaknya jenis makanan dan minuman cepat saji akan meningkatkan daya konsumsi remaja terhadapa makanan cepat saji. Sehingga dalam pengabdian masyarakat kali ini kami dalam tim mengangkat pemaparan hitung kalori makanan kekinian.
Peningkatan Pengetahuan dan Keterampilan Siswa Melalui Pengenalan Proses Penjernihan Air Secara Sederhana
Authors: Shofi Muh. , Istiqomah Nurul , Ramadani Aisyah Hadi , Humairoh Durroh , Fitri Inayah
Published: July 2020

Air merupakan sumber kehidupan bagi mahluk hidup. Air merupakan kebutuhan yang paling penting dalam kehidupan manusia terutama air tawar yang bersih dan sehat. Namun demikian, kelangkaan dan kesulitan mendapatkan air bersih dan layak pakai menjadi permasalahan yang mulai muncul di banyak tempat dan semakin mendesak dari tahun ke tahun. Salah satu cara untuk mengatasi kendala tersebut dengan menjernihkan air dengan bantuan pasir, sabut air, pecahan genting, pasir, dan arang. Program ini bermaksud memberi edukasi pada siswa mengenai cara penjernihan air secara sederhana. Tujuan dari dilaksanakan program ini yaitu memberikan informasi tentang penjernihan air secara sederhana dengan menggunakan  pasir, sabut air, pecahan genting, pasir, dan arang di SD Islamic International School Pesantren Sabilil Muttaqien Kediri. Metode yang digunakan dalam proses penyuluhan yang dilaksanakan di ini yaitu dengan menggunakan tiga metode yaitu: metode ceramah, tanya jawab dan demonstrasi menggunakan pasir, sabut air, pecahan genting, pasir, dan arang. Hasil yang dicapai adalah para siswa mengetahui bahaya air yang tercemar cara menjernihkan air secara sederhana. Antusias para siswa terlihat saat praktik cara menjernihkan air secara sederhana dengan menggunakan pasir, sabut air, pecahan genting, pasir, dan arang.
Fenomena perilaku bullying pada anak di tingkat Sekolah Dasar
Authors: Octavia Dian , Puspita Mefrie , Yan Loriza Sativa
Published: July 2020

Latar Belakang : Fenomena bullying dapat berawal dari tingkat keagresifan perilaku yang tidka terkendali pada masa anak sekolah dasar.  Namun hal ini dapat dicegah dengan meningkatkan pengawasan pergaulan negatif dari anak dan teman-teman mulai dari mencontohkan hal- hal yang baik, lebih menyaring teman-teman anak yang memberikan efek positive. Penelitian ini bertujuan untuk mengidentifikasi fenomena bullying di kalangan anak sekolah dasar di Kota Jambi

Metode : Penelitian ini merupakan penelitian kuantitatif dengan desain penelitian Cross Sectional. Penelitian dilakukan di SDN 116/IV Kota Jambi tahun 2019. Sampel penelitian berjumlah 66 orang siswa dipilih menggunakan teknik simple random sampling

Hasil : Hasil penelitian menunjukkan bahwa sebagian besar responden adalah perempuan (57,6%) yang berusia 10 tahun (66,7%) dan memiliki gambaran kategori perilaku bullying yang berat (63,6%).

Kesimpulan : pihak sekolah diharapkan perlu mengadakan kebijakan anti bullying di sekolah dengan memberikan teguran, hukuman serta melakukan promosi dengan memasang poster anti bullying di setiap ruangan kelas
Algorithms for prevention and treatment of incontinence-associated dermatitis
Authors: Salomé Geraldo Magela , Rocha Cleber Aparecido da , Miranda Flávio Dutra , Alves José Ronaldo , Dutra Rosimar Aparecida Alves , Tenório Amanda Gabriele
Published: July 2020

Objective: To build and validate algorithms for prevention and treatment of incontinence-associated dermatitis. Method: A methodological study. An integrative review of articles published from 2009 to 2019 was carried out after a literature search in the main Health Sciences databases for the construction of the algorithms. The algorithms were evaluated by 27 nurses using the Delphi technique. The content validity index was used for data analysis. Results: The judges evaluated the algorithms from inadequate to adequate in the first round of consultation, and from adequate to totally adequate in the second round of consultation. The global content validity index was 0.923 in the first consultation and 1.0 in the second consultation. Conclusion: After reviewing the literature, the algorithms were constructed and validated by professionals with experience in the area, reaching agreement among the judges in the second round of consultation.
Digital technologies in the prevention of diabetic foot: a review on mobile applications
Authors: Dabó Sabado Gomes , Brandão Maria Girlane Sousa Albuquerque , Araújo Thiago Moura de , Frota Natasha Marques , Veras Vivian Saraiva
Published: July 2020

Analyze mobile applications developed for prevention of diabetic foot. Method: Integrative review, with searches in LILACS, BDENF, Scopus, Web of Science and PubMed databases, from 2000 to 2019. After eligibility criteria, the sample consisted of nine articles. Results: The mobile applications for prevention of diabetic foot are based on online foot monitoring through images, evaluation of thermal images of the feet, capture of images of the sole of the foot, recommendations for self-care with the feet and classification of the risk of diabetic foot. The analysis of the articles shows that the applications were considered a good prevention strategy. Conclusion: This study enabled the identification of nine mobile applications developed for prevention of diabetic foot, with predominance in the use of thermometry as the main measure for prevention and early detection of diabetic foot ulcers, with the use of thermal images and sensors associated with the mobile application.
Tecnologias digitais na prevenção de pé diabético: uma revisão sobre aplicativos móveis
Authors: Dabó Sabado Gomes , Brandão Maria Girlane Sousa Albuquerque , Araújo Thiago Moura de , Frota Natasha Marques , Veras Vivian Saraiva
Published: July 2020

Objetivo: Analisar aplicativos móveis desenvolvidos para prevenção do pé diabético. Método: Revisão integrativa, com buscas nas bases de dados LILACS, BDENF, Scopus, Web of Science e PubMed, no período de 2000 a 2019. Após critérios de elegibilidade, a amostra constituiu-se de nove artigos. Resultados: Os aplicativos móveis para prevenção do pé diabético, se baseiam no monitoramento online dos pés por meio de imagens, avaliação de imagens térmicas dos pés, captura de imagens da planta do pé, recomendações de autocuidado com os pés e classificação do risco de pé diabético. A análise dos artigos evidencia que os aplicativos foram considerados como boa estratégia de prevenção. Conclusão: A realização deste estudo possibilitou a identificação de nove aplicativos móveis desenvolvidos para prevenção do pé diabético, com predomínio no uso da termometria como principal medida para prevenção e detecção precoce das úlceras do pé diabético, com utilização de imagens térmicas e sensores associados ao aplicativo móvel.
MOBIS-COVID19/11: Results as of 22/06/2020 (post-lockdown)
Authors: Molloy Joseph , Tchervenkov Christopher , Schatzmann Thomas , Schoeman Beaumont , Hintermann Beat , Axhausen Kay W.
Published: July 2020

To slow down the spread of the Coronavirus, the population has been
instructed to stay at home if possible. This measure consequently has a
major impact on our daily mobility behaviour. But who is being affected,
and how? The MOBIS-COVID-19 research project, an initiative of ETH
Zurich and the University of Basel, is a continuation of the original
MOBIS study. The aim of the project is to get a picture of how the
crisis is affecting mobility and everyday life in Switzerland.
MOBIS-COVID19/14: Results as of 13/07/2020 (Post-lockdown)
Authors: Molloy Joseph , Tchervenkov Christopher , Schatzmann Thomas , Schoeman Beaumont , Hintermann Beat , Axhausen Kay W.
Published: July 2020

To slow down the spread of the Coronavirus, the population has been
instructed to stay at home if possible. This measure consequently has a
major impact on our daily mobility behaviour. But who is being affected,
and how? The MOBIS-COVID-19 research project, an initiative of ETH
Zurich and the University of Basel, is a continuation of the original
MOBIS study. The aim of the project is to get a picture of how the
crisis is affecting mobility and everyday life in Switzerland.
ASPM is differentially expressed in high-grade serous ovarian cancers.
Authors: Mamoor Shahan
Published: July 2020

Ovarian cancer is the most lethal gynecologic cancer (1). We sought to identify genes associated with high-grade serous ovarian cancer (HGSC) by comparing global gene expression profiles of normal ovary with that of primary tumors from women diagnosed with HGSC using published microarray data (2, 3). We found significant differential expression of the gene encoding ASPM in high-grade serous ovarian tumors.
Konsep Keterasingan Dalam Film "Aisyah Biarkan Kami Bersaudara" Karya Herwin Novianto
Authors: Susiati Susiati
Published: July 2020

AbstrakPenelitian ini bertujuan mendeskripsikan konsep keterasingn dalam film “Aisyah Biarkan Kami Bersaudara” karya Herwin Novianto. Penelitian ini merupakan penelitian kualitatif. Data dikumpulkan menggunakan metode audio visual, yakni dengan melihat dan mendengar suatu objek dari gambar dan suara. Sementara itu, teknik pengumpulan data menggunakan teknik simak dan catat. Data dianalisis secara deskriptif sesuai dengan teori konsep eksistensi manusia Koeswara yang meliputi empat jenis, yakni kebersamaan dan cinta, pertentangan, keterasingan dan kesepian, serta kematian. Hasil penelitian menunjukkan bahwa konsep keterasingan manusia dalam film “Aisyah Biarkan Kami Bersaudara” karya Herwin Novianto meliputi kesedihan, kegelisahan, kejengkelan, kekhawatiran, ketakutan, dan kebohongan. Kata kunci: konsep keterasingan, film, Aisyah Biarkan Kami Bersaudara
The impact of anodal tDCS on attentional networks as a function of trait anxiety and depressive symptoms: A preregistered double-blind sham-controlled experiment
Authors: Coussement Charlotte , Riesco de Vega Monica , Heeren Alexandre
Published: July 2020

Attention is a multifaceted construct, including three distinct attentional networks: the alerting, orienting, and executive conflict networks. Recently, researchers have started to envision strategies to enhance the attentional networks, and transcranial Direct Current Stimulation (tDCS) has emerged as a promising tool to do so, especially regarding the executive conflict network. On the other hand, other research lines have suggested that anodal tDCS might yield more substantial impacts among depressive and anxious participants. In this preregistered study, we thus examined two questions. First, we wanted to replicate previous observations and tested whether anodal tDCS does improve the executive conflict network's efficiency. Second, we set out to clarify the impact of anxiety and depressive symptoms on this effect. To do so, we adopted a double-blind within-subject protocol in an unselected sample (n = 50) and delivered a single session of anodal— applied over the dorsolateral part of the left prefrontal cortex—versus sham tDCS during the completion of a task assessing the attentional networks. We assessed anxiety and depressive symptoms at baseline. Although there were no significant direct effects of tDCS on the attentional networks, we found that the higher the levels of depression and trait anxiety, the larger the executive conflict network's enhancement during tDCS. By highlighting the importance of trait anxiety and depression when considering the impact of tDCS on the attentional networks, this study fulfills a valuable niche in clinical neuroscience, wherein preclinical data provide critical clues for larger, more definitive future translational efforts.
Absorption and enjoyment during listening to acoustically masked stories
Authors: Herrmann Bjorn , Johnsrude Ingrid
Published: July 2020

Comprehension of speech masked by background sound requires increased cognitive processing, which makes listening effortful. Research in hearing has focused on such challenging listening experiences, in part because they are thought to contribute to social withdrawal in people with hearing impairment. Research has focused less on positive listening experiences, such as enjoyment and absorption/engagement, despite their potential importance in motivating effortful listening. Moreover, the artificial speech materials – such as disconnected, brief sentences – commonly utilized to investigate speech intelligibility and listening effort may be ill-suited to capture positive experiences when listening is challenging. Here, we investigate how listening to naturalistic spoken stories under acoustic challenges influences the quality of listening experiences. We show (1) that story absorption and enjoyment are only minimally affected by moderate speech masking although listening effort increases; (2) that familiarity with the Harry Potter books and/or movies, providing thematic knowledge, increases absorption and enjoyment and reduces listening effort when listening to the audio of a Harry-Potter summary presented in multi-talker babble; and (3) that absorption and enjoyment increase and effort decreases over time as individuals listen to several stories successively in multi-talker babble. Our research indicates that naturalistic, spoken stories can reveal several concurrent listening experiences and that familiarity with a narrative can increase engagement and reduce effort. Our work also demonstrates that, although listening effort may increase with speech degradation, listeners may still find the experience both absorbing and enjoyable.