bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS PEMBERLAKUAN PAJAK UMKM TERHADAP TINGKAT KEPATUHAN WAJIB PAJAK UMKM
Authors: Alfian Nurul , Saiful Saiful , Gazali Gazali , Bustaram Isnain , Djaja Herman , Amar Siti Salama
Published: July 2023

The Analysis of tax enforcement through the level of tax compliance UMKM at Surabaya city. The formulation of the problem in this research is how the tax compliance growth of taxpayer at the taxpayer after the transfer of PP number 46 year 2013 to PP number 23 year 2018. The purpose of this study is to find out if any changes to the government regulation affect taxpayers compliance in fulfilling obigations. This research includes descriptive research, the technique to collect theses writing data using questionnaire methods. The data used is primary data. The results showed that UMKM have received government regulation No. 23 year 2018. This is seen from the dominant UMKM respondents answered agree with the taxpayer's understanding indicators, and the tax sanctions on the taxpayer's level of compliance .
BUDAYA PATERNALISTIK DALAM PERUMUSAN KEBIJAKAN PUBLIK (Mempertegas Integritas Perumus Kebijakan di Kabupaten Pamekasan)
Authors: Sapto Wahyono Hasbullah &
Published: July 2023

Kebudayaan politik merupakan sesuatu yang penting pada setiap kehidupan masyarakat, baik dalam sistem politik tradisional, transisional, maupun modern, sehingga menjadi aspek yang siginifikan dalam menentukan langkah masyarakat ke arah yang lebih baik. Sebagai faktor yang sangat berpengaruh terhadap  perilaku politik seseorang, kajian terhadap kebijakan tidak bisa dilepaskan dari budaya politik khususnya budaya paternalistik yang tumbuh dan berkembang di tengah-tegah masyarakat. Seberapa besar harmonisasi yang dicapai oleh budaya paternalistik dengan kebijakan publik merupakan parameter dari pembangunan desa itu sendiri.Budaya paternalisme merupakan sistem ketokohan dengan memposisikan atasan sebagai pihak yang harus dihormati  oleh bawahannya. sedangkan di lain sisi, bawahan hanya dipandang sebagai alat untuk menjalankan perintah atasannya. Ada kecenderungan bahwa aparat birokrasi yang telah menjadi pimpinan mempertahankan   kedudukannya   karena   dirasakan mampu memberikan  keuntungan finansial dan sosial. Paternalistik akan berdampak terhadap kinerja aparat bekerja  secara lamban  karena orang yang ada di dalamnya cenderung menurut  dan tunduk atau istilah bahasa madura ialah Enggie Buten pada  atasannya  tanpa   memiliki    inisiatif mengembangkan diri. Bawahan berada  pada  posisi tergantung sehingga tidak berani mengambil keputusan meskipun keputusan itu menyangkut kepentingan yang mendesak atau kepentingan masyarakat Sehingga berdampak vatal dalam pencapaian out put yang positif dalam  pengambilan keputusan. Maka sangat diperlukan pakta Integritas perumus atau Actor Policy Macker  sebagai penentu arah kebijakan publik. Paternalisme tumbuh  subur karena dipengaruhi oleh kultur feodal yang sebagian besar wilayah di Indonesia semula  merupakan   daerah bekas kerajaan. Wilayah-wilayah bekas kerajaan  ini telah mempunyai  sistem nilai, norma,  dan adat kebiasaan  yang selalu  menjunjung   tinggi dan mengagungkan   penguasa  sebagai orang yang harus dihormati karena mereka  telah memberikan  kehidupan  dan pengayoman  bagi warga masyarakat.
PEMANFAATAN GADAI SAWAH OLEH MURTAHIN PERSPEKTIF HUKUM ISLAM (Studi di Desa Pademawu Timur Kecamatan Pademawu Kabupaten Pamekasan)
Authors: Anni Puji Astutik Marsum &
Published: July 2023

Artikel ini mengusung tentang fenomena menarik berkenaan dengan sistem praktik gadai  sesuai dengan syari’at Islam, selain tidak ada pihak yang dirugikan juga adanya sikap saling tolong-menolong. Sedangkan praktik gadai dengan hasil untuk penerima gadai (murtahin) artinya murtahin memiliki hak sepenuhnya atas barang yang digadaikan (sawah) selama hutang belum bisa dibayar oleh pihak yang berhutang (rahin), dan pihak yang berpiutang (murtahin) mengambil manfaat sepenuhnya. Pada dasarnya barang gadai tidak boleh diambil manfaatnya baik oleh pemiliknya maupun oleh penerima gadai. Hal ini disebabkan status barang tersebut hanya sebagai jaminan utang dan sebagai amanat bagi penerimanya. Apabila mendapat izin dari masing-masing pihak yang bersangkutan, maka barang tersebut boleh dimanfaatkan. Oleh karena itu, agar di dalam perjanjian gadai itu tercantum ketentuan jika penggadai atau penerima gadai meminta izin untuk memanfaatkan barang gadai, maka hasilnya menjadi milik bersama. Ketentuan ini dimaksudkan untuk menghindari harta benda tidak berfungsi atau mubazir. Sedangkan pedoman hukum yang digunakan menggunakan hukum-hukum Allah sebagaimana yang termaktub dalam al-Qur’an dan al-Sunnah.
93 HARBİ’NDE OSMANLI ORDUSUNDA GAYRİMÜSLİM GÖNÜLLÜLER
Authors: ÖZKAN Ayşe
Published: July 2023

24 Nisan 1877’de Rusya, Osmanlı Devleti’ne savaş ilan etmiştir. Bu çalışmada 93 Harbi denilen 1877-1878 Osmanlı-Rus Savaşı’nda Osmanlı ordusunda bulunan gayrimüslim gönüllüler incelenmiştir. Osmanlı ordusunda açık olması dolayısıyla gayrimüslimlerden de gönüllü asker alımları başlamıştır. Özellikle 1876 Osmanlı-Sırp-Karadağ Savaşı’nda Hıristiyanlardan gönüllü asker yazan Dimostini Efendi bu savaşta da aynı şekilde davranmış ve gönüllü toplamıştır. Osmanlı tebaası olmayan gönüllülerde Osmanlı Devleti ordusuna katılıp Rusya’ya karşı savaşmak istemişlerdir. Bürüksel, Roma ve Berlin elçiliklerine başvuran kişiler gönüllü olmak istemişlerdir. Özellikle Macarlar bir önceki savaşta verdikleri desteğin bir benzerini bu savaşta da sergilemişlerdir. Askeri anlamda olduğu gibi tıbbi anlamda da destek veren Macaristan’dan subaylar ve doktorlar gönüllü olmuşlardır. İngilizler de aynı şekilde destek vermişlerdir. Lehler de Macarlar ve İngilizler gibi İstanbul’da ecnebilerden kurulan gönüllü fırkasına katılmak istemişlerdir. Hatta Ruslara karşı Lehler ile Osmanlı Devletinin birlikte hareket etmesi ve Lehlerin Ruslara karşı isyanında Osmanlı Devletinin destek vermesi istenmiştir.
Changing Geography of Pune Urban Area
Authors: Nalavade S.B.
Published: July 2023

Pune, also known as Poona, is a significant city in Western India, often called the 'Queen of the Deccan' due to its elevated position, pleasant climate, and surrounding hills. It has earned various nicknames like 'Pensioner's Paradise,' 'Oxford of the East,' 'Detroit of India,' and the 'cultural capital of Maharashtra.' The city has grown from a small agricultural settlement in the 8th century to a metropolis spanning over 700 sq. km with a population of around 4 million. Pune has a rich historical background, witnessing the rule of different dynasties, including the Marathas and the British. It became the 'Monsoon Capital' during British rule and is home to numerous educational institutes, research institutes, and defense establishments. Pune's physical setting includes its location on the Deccan Plateau, surrounded by hills and near the confluence of several rivers. The city experiences a typical monsoonal climate with distinct seasons. Over time, Pune has witnessed significant population and area growth, expanding from 5 sq. km to 700 sq. km since 1818. The urban population has also increased from 1.64 lakh in 1901 to an estimated 42 lakh in 2001. However, this growth has resulted in changes in land use, particularly a decrease in agricultural and grassland-scrub areas. The urban expansion has affected natural habitats in the region.
A síndrome de Burnout nos profissionais de enfermagem nas unidades de terapia intensiva
Authors: Viola Giovana Inocencia Moroni , Pergola-Marconato Aline Maino , Figueiredo Clesyane Alves
Published: July 2023

Os profissionais de Enfermagem enfrentam elevados níveis de estresse, ocasionados pela exposição diária às emergências, em que as condições críticas dos pacientes exigem rapidez na tomada de decisões, tornando-se um fator determinante de sobrevida. A Unidade de Terapia Intensiva (UTI) demanda elevada carga de trabalho aos profissionais de Enfermagem, exigindo que o dimensionamento da equipe de Enfermagem seja adequado para que não comprometa a qualidade do cuidado e a segurança dos pacientes. O objetivo deste estudo é descrever, os fatores de risco para a Síndrome de Burnout nos profissionais que atuam em Unidade de Terapia Intensiva. Trata-se de uma revisão narrativa de literatura com busca em artigos científicos nas bases de dados on-line: BIREME e SciELO, no período de 2015 a 2020. A complexidade do ambiente crítico expõe os profissionais de Enfermagem a elevados níveis de estresse, ocasionado pela sobrecarga de trabalho, jornadas exaustivas e dimensionamento inadequado de profissionais que atuam em regime de rotatividade. Sendo assim, é necessário adotar medidas, a fim de minimizar a exposição à Síndrome de Burnout.
SUPPLIER SELECTION IN AN INDUSTRY OF SHORT LIFECYCLE PRODUCTS USING BAYESIAN NETWORK ANALYSIS
Authors: Z. U. Abidin
Published: July 2023

This study presented an innovative Bayesian Network (BN) modelling andsimulation for supplier selection problem of an actual electronic parts manufacturing firm of Pakistan.The list of qualitative and quantitative factors which affect this supplier selection decision wasextracted from a variety of studies in literature. The problem was modelled and solved in respectiveBN software platform using the standard recommended procedure. Results showed that ―Quality‖ and ―Costs‖ were the most crucial factors for the Short Life Cycle(SLP) products industry underinvestigation. The supplier alternative which was strong in these factors, had emerged as the most suitable option. The results were found to be beneficial for other SLP industries of Pakistan too.
ANEXPOSITIONANALYSIS OF FACIAL EXPRESSION RECOGNITION TECHNIQUES
Authors: A. H. Butt
Published: July 2023

This studycompared the technique such as Gabor-wavelet filter banks and LocalBinary Patterns (LBP) that were commonly used for facial expression recognition.Broad experimentalphases were designed to analyze the accuracy and efficiency of each state of art techniques regardingfacial expression recognition. A close analysis of the Receiver Operating Characteristics (ROC) andoverall accuracy of the results for well-known facial databasesrevealedthat the LBPbased extraction offacial expression features was the most efficient and effective technique.
BIFENTHRIN INDUCED HISTOPATHOLOGICAL ALTERATIONS IN KIDNEY OF CYPRINUS CARPIO
Authors: N. Nazir
Published: July 2023

Bifenthrin is used as insecticide in agriculture. Present manuscript deals with the poisonous outcome of bifenthrin on histology of kidney of fish Cyprinus carpio. Freshwater fish Cyprinus carpio was used in this experimental study. An aggregate of 30 fish were arbitrarily separated into 3 gatherings A, B and C. Group A was kept as control while Group B and C were treated as exploratory. All fish were kept into glass aquaria at room temperature. During experiment, group A (control) was kept in normal water while bifenthrin was added in water of experimental groups B & C. The water of all groups was changed on daily basis. Kidney sampleswere collected after 48 & 96 hours exposure and processed for histopathological study. Behavioural pattern and histopathological changes of kidney of Cyprinus carpio were noted. Major changes, for example, Glomerular constriction, extreme degeneration of the tubules, hypertrophy, necrosis and pyknosis were observe under the microscope. Thus, bifenthrin as pesticide should beused carefully to protect the health of aquatic food animals.
DIFFERENCES IN BIOACCUMULATION OF HEAVY METALS AND METALLOIDS BETWEEN BARBS AND CALAMUS OF TAIL FEATHERS OF WHITE BACKED VULTURES (GYPS AFRICANUS)
Authors: S. Ashraf
Published: July 2023

Current study was designed to validate the use of tail feathers as non-invasivebiomonitoring tool and to compare its barb and calamus parts for bioaccumulation of heavy metals viz.Cd, Cr, Pb, Cu, Hg and As in white backed vulture (Gyps africanus). A total of 8 tail feathers samplescollected from eight birds were analyzed. All the studied heavy metals except Hg and As were detectedin tail feathers of G. Africanus. We corroborated the use of tail feathers as non-invasive biomonitoringtool for all the heavy metals except Hg and As. In general, metals in feathers followed the trend asPb>Cd>Cr>Cu. Concentrations of trace metals were higher in barbs than calamus reflecting possibleexternal deposition. Comparison of heavy metals revealed non-significant (P> 0.05) differencesbetween barbs and calamus parts. We concluded that barbs of feathers are promising biomonitoringtool for metals contamination.
PRINCIPAL COMPONENT ANALYSIS OF KAIL SHEEP BASED ON BODY MEASUREMENTS
Authors: Z. H. Kuthu  , Z.Ahmed  , M.Nawaz  , G.Bila  , M.Zubair  , I.Ahmed  , F.A.Kiani  , M. Ikram
Published: July 2023

The information on principal component analysis (PCA) of kail sheep was generated using 16 different morphomteriacal traits. A total of 368 Kail sheep individuals were selected from different ecological zone of Azad Jammu Kahmir during the summer of 2020. The coefficient of correlation between these traits were found highly correlate with other morphometric traits of this breed. The PC extract two components and explaning total variance of 67 % and 60% respectively. PC1 has high variance while PC2 high association eith these traits. The application of PC analysis in kail sheep reduce the number of factor and variable a draw a more informative information about morphometric traits. These component can be used in breeding and conservation programme of this breed.
STRATEGIC MANAGEMENT FRAMEWORK OF GROUND WATER QUALITY FOR HEALTH CARE ALONG JINNAH ROAD GUJRANWALA CITY
Authors: M. Y. Raza  , I.Ahmed  , M.Ilyas
Published: July 2023

The objective of the research was to investigate/assess the water quality standardaccording to WHO because the study area of research was a canal distributary of 32 cusec dischargefor the period of 25 years up to 1972 and thereafter sewage remained flowing period for 50 years. In2021 PHE Department converted to 42” Ø sewer pipe and polluted water Nallah up to Noshehra Roadand constructed a metaled road. The seepage water samples were collected and tested by the NoshehraRoad Laboratory. Accordingly, the results identified the water-borne diseases, metals, chemical,biological, fecal, and E-coli bacteria. It was therefore necessary to research the causes of diseases forthe safety of health care. Drinking water remedial measures were asked of Health Deptt and otherconcerned Authorities related to Gujranwala City. The quality of water was assessed by comparingWHO standards. The seepage water contaminated was obtained through hand pumps and dug wellsbefore Municipal water distribution through overhead reservoirs (OHR) duly chlorinated by PublicHealth Engg Department now WASA and the Municipal Corporation. There are certain industries,falling untreated effluents in drains, causing cancer and other fatal diseases, through agricultural foods,due to sullage water irrigating the vegetables, in the vicinity of subrubs area of the city.
Nonlinear diffusion with the p-Laplacian in a Black-Scholes-type model
Authors: Takac Peter
Published: July 2023

We present a new nonlinear version of the well-known Black-Scholes model for option pricing in financial mathematics. The nonlinear Black-Scholes partial differential equation is based on the quasilinear diffusion term with the p-Laplace operator \(\Delta_p\) for \(1 < p < \infty\). The existence and uniqueness of a weak solution in a weighted Sobolev space is proved, first, by methods for nonlinear parabolic problems using the Gel'fand triplet and,  alternatively, by a method based on nonlinear semigroups. Finally, possible choices of other weighted Sobolev spaces are discussed to produce a function space setting more realistic in financial mathematics.
See also https://ejde.math.txstate.edu/special/02/t1/abstr.html
Factores de riesgo relacionados a histerectomía obstétrica en el hospital nacional Arzobispo durante los años 2017 – 2019
Authors:   , Altamirano Enciso Jakelyne
Published: July 2023

Objetivo: Determinar los factores de riesgo relacionados a histerectomía obstétrica en el Hospital Nacional Arzobispo Loayza durante los años enero 2017 a julio 2019. Metodología: Se realizó una investigación de nivel explicativo no experimental, analítico, observacional, transversal, tipo de casos y controles. Se estudió a 27 casos y 54 controles. La información recolectada fue obtenida de historias clínicas mediante una ficha de recolección de datos. Resultados: Se obtuvo que los factores de riesgo para histerectomía obstétrica es la edad materna avanzada [OR=5.765, IC 95% (1.724 - 19.274), p=0.002, Chi2=9.205], ser multigesta [OR=11.946, IC 95% (1.495 - 95.451); p=0.005, Fisher=0.004], el periodo intergenésico corto [OR=8.594, IC 95% (2.401 - 30.765); p<0.001, CC=11.138], la cesárea previa [OR=9.1, IC 95% (3.074 - 26.938); p<0.001, Chi2=18.225], la hemorragia post parto [OR=46, IC 95% (11.167 - 189.493); p<0.001, Fisher=0.00], atonía uterina [OR=15.625, IC 95% (4.387 - 55.650); p<0.001, CC=20.637], acretismo placentario [OR=6.4, IC 95% (3.622 - 11.309); p<0.001, Fisher=0.00] y la presencia de placenta previa [OR=6.738, IC 95% (2.033 - 22.332); p<0.001, Chi2=11.254]. Así mismo, según la prueba de OR, no se encontró relación estadísticamente significativa entre la histerectomía obstétrica y el grado de instrucción, lugar de procedencia, la paridad, control prenatal, rotura uterina y corioamnionitis. Conclusiones: Se encontró que el principal factor de riesgo para histerectomía obstétrica es la hemorragia post parto, asimismo la edad materna avanzada, el periodo intergenésico corto, antecedente de cesárea previa, la multigestación, atonía uterina, acretismo placentario, placenta previa y el parto pretérmino son factores de riesgo para histerectomía obstétrica.
Kasut Kumis Semeru: Metafora Anggrek Selop Tanaman Endemik Jawa Timur dalam Penciptaan Busana Karya Tugas Akhir
Authors: Abdi Isa Ni Putu Maria , K. Tenaya A.A. Ngurah Anom Mayun , Mudarahayu Made Tiartini
Published: July 2023

Anggrek merupakan tanaman bunga dengan nilai jual tinggi. Paphiopedilum glaucophyllum J.J.Sm. var. glaucophyllum yang lebih dikenal sebagai anggrek selop atau anggrek kantung merupakan salah satu jenis anggrek endemik Jawa Timur yang termasuk   dalam   kategori   tumbuhan langka di Indonesia. Habitat alami anggrek selop berada di bukit sebelah selatan Gunung Semeru, Lumajang Jawa Timur. Pada habitat aslinya anggrek ini hidup menempel pada dinding – dinding yang tinggi dan curam. Pada karya tugas akhir ini saya membuat tiga tingkatan busana yaitu ready to wear, deluxe, dan couture dengan menggunakan anggrek selop sebagai ide pemantik. Setelah membedah ide pemantik saya mendapatkan lima kata kunci yaitu mahkota bunga, mengkilap, kantong/ labellum, hijau dengan corak coklat, dan ungu. Dari kata kunci yang saya dapatkan kemudia saya mengimplementasikan menggunakan gaya bahasa metafora. Metode penciptaan karya yang saya gunakan dalam menciptakan busana ready to wear, deluxe dan couture adalah metode milik Tjok Istri Ratna Cora yaitu “ FRANGIPANI The Secret Steps of Art Fashion ”, dimana FRANGIPANI memiliki 10 tahapan yang terdiri dari ide pemantik (design brief), reset sumber seni (researching and sourcing), analisa estetika elemen seni (analizing art fashion element), menarasikan ide seni fashion ke dalam visualisasi dua dimensi atau tiga dimensi (narrating of art fashion idea by 2D or 3D visualitation), memberikan jiwa - taksu (giving a soul-taksu), menginterpretasikan keunikan (interpreting of singularity), promosi (promoting), afirmasi merek (affirmation branding), Mengarahkan produksi seni fashion melalui metode kapitalis humanis (navigating art fashion production by humanist capitalism method), memperkenalkan bisnis fashion (introducing the art fashion business).
A Dance Work Representing Ida Bagus Blangsinga’s Life Journey (The Maestro of Kebyar Duduk Dance in Blangsinga Style)
Authors: Triana Titania Manuaba Ida Ayu , Dibia I Wayan , Sariada I Ketut
Published: July 2023

This work aims to represent the figure of Ida Bagus Blangsinga, a master of the Kebyar Duduk dance in Blangsinga style. The method of creation used in this work uses the creation method which includes assessment, experimentation, and formation. This method is easily understood by the stylist to express and visualize several scenes in the work. The form of the chosen work is a new creation dance, because it provides space for development according to the wishes of the stylist. This work is danced by six female dancers and one male dancer using soft make-up and fashion that supports each part of the work. This work uses the fan and reverberation properties. This dance is made as a contribution to the development of Balinese dance especially to the new generation.
Tri Hita Karana: A contemporary sculpture creation
Authors: Sanjaya Pande Putu Ogy Mega , Adnyana I Wayan , Muka I Ketut
Published: July 2023

Tri Hita Karana in Hinduism is the understanding of three main things that cause prosperity for human life which consist of Parhyangan, Pawongan, and Palemahan. The phenomenon stimulates creator to create a sculpture that aimed to provide an understanding related to Tri Hita Karana. The method applied in this creation uses five stages, namely the search for ideas, the search for materials, experiments, the embodiment of the work, and the presentation of the work. In this creation of three-dimensional works of art in the form of sculptures, the creator tries to express Tri Hita Karana issues with the concept of recycle, a process to turn used materials into new materials with the aim of preventing waste that can actually be turned into useful goods. The form of the work will be in the form of contemporary sculpture by displaying unique and authentic new forms.

Keywords: Tri Hita Karana, recycle, contemporary sculpture.
Everyday Life of Women Workers in Badung Market (A Documentary Photography Study)
Authors: Putra Febrian , Yudarta I Gede , Mudra I Wayan
Published: July 2023

Capturing the everyday life of women workers in the badung market through documentary photography is a work that reveals the lives of women workers in the Badung Market in a powerful and effective way by using visual storytelling techniques. This technique involves using images and narration that complement each other to bring the audience into the story presented in images that can be used to present the lives of women workers in the Badung Market, while narration can be used to provide background on the lives of these women workers, as well as describe conflicts. they face in carrying out their work. The purpose of creating this work is to provide a visual depiction of the daily life of female workers, to use documentary photography as a medium to reveal the beauty and dignity of the work of female laborers as porters at Badung Market, Bali. The research method used in this study is a qualitative method with a case study approach. Data analysis techniques used include descriptive analysis, qualitative analysis, and thematic analysis. The result of creating this work focuses on the lives of female laborers transporting goods at the Badung Market in raising awareness about social issues, able to describe the activities carried out by women workers in the Badung Market in each photo so that they can provide in-depth information.
PENERAPAN KOMUNIKASI PERSUASIF MELALUI DESAIN POSTER UNTUK KONTEN MEDIA SOSIAL PERUM JASA TIRTA II
Authors: Salsabila Annida , Ramlan Ramlan
Published: July 2023

Poster merupakan media komunikasi yang dapat digunakan untuk menyampaikan pesan agar lebih mudah dipahami. Komunikasi persuasif dapat diperlukan dalam perancangan media poster dan media sosial sebagai tempat membagikan suatu informasi ke ranah publik. Pembuatan tema poster dapat menggunakan permasalahan yang ada dilingkungan setempat seperti permasalahan tumpukan sampah di aliran sungai. Sampah akan menjadi suatu masalah apabila tidak ditangani dengan benar. Membuang sampah ke aliran sungai dapat menyebabkan pencemaran air yang dapat merugikan biota air tawar serta masyarakat yang tinggal dekat dengan daerah aliran sungai. Sehingga media poster sangat berguna untuk menyadarkan kembali masyarakat terhadap pentingnya menjaga kelestarian sungai dan lingkungan sekitar agar keseimbangan alam tetap terjaga.
Gestão Cultural de Pequenas Cidades
Authors: Da Silva Zacarias Vinícius Santos
Published: July 2023

O artigo apresenta as incursões teórico-metodológicas de criação do Programa Muritiba Criativa: proposição de caminhos políticos e administrativos para a solução da desocupação e desemprego através de ativos culturais em Muritiba no Recôncavo da Bahia. A política trata, basicamente, da transferência alocativa de parte dos recursos gastos no Palco e Produções da Festa do Senhor do Bonfim de Muritiba para a receita do Fundo Municipal de Cultura. Para tal, o trabalho confere fortes críticas às administrações públicas da cultura, desde a limitação de ações à dimensão econômica na implementação do Sistema Nacional de Cultura, até o patrimonialismo predominante nos peque nos municípios, ambos responsáveis pelo sufocamento da cidadania cultural.
Role of Sex in Participation During Virtual Grand Rounds in Ophthalmology
Authors: Hennein Lauren , Liu Yingna , Shuman Elizabeth A. , Kim Jessica S. , Moss Heather E. , Keenan Jeremy D. , Seitzman Gerami D.
Published: July 2023

Importance

Sex disparities exist in academia. Female attendees consistently ask fewer questions in scientific meetings than male attendees, even when they constitute half of the audience.

Objective

To assess the role of sex in participation during virtual grand rounds (GR) at a major academic center.

Design, Setting, and Participants

In this prospective cohort study, attendees of the Department of Ophthalmology at the University of California, San Francisco, GR from April 2020 to April 2021 were included. All GR were held via a synchronous live video communication platform. During each GR session, a predesignated attendee collected the sex of all attendees, sex of the GR speaker, and sex of each individual who asked a question to the GR speaker in order of inquiry. The GR speakers and audience were unaware of the study. Data were analyzed from June 2021 to April 2023.

Main Outcome and Measures

The main analysis assessed the association between being female and asking one of the first 3 questions.

Results

A total of 31 virtual ophthalmology GR sessions were observed. The sex of the GR speaker was female in 13 of 31 sessions (42%). The mean (SD) percentage of audience sex at each of the GR sessions was 47% (0.05) female, 45% (0.06) male, and 8% (0.03) unknown. Male attendees were more likely to ask one of the first 3 questions compared with female attendees (prevalence ratio, 3.1; 95% CI, 2.1-4.5; P < .001).

Conclusions and Relevance

Male attendees were more likely to ask questions during virtual ophthalmology GR compared with female attendees at an academic medical center. Strategies to encourage equal participation of sex in academic discourse should be encouraged.
Farmers’ acceptance of robotics and unmanned aerial vehicles: A systematic review
Authors: Degieter Margo , De Steur Hans , Tran Duc , Gellynck Xavier , Schouteten Joachim J.
Published: July 2023

Recently, new agricultural technologies have emerged to increase sustainable food production, often referred to as “Agriculture 4.0.” They consist of more advanced precision agriculture technologies, such as sensors, robotics, and unmanned aerial vehicles (UAVs), which can lead to environmental and economic benefits for farmers and society. Despite the potential benefits of Agriculture 4.0 technologies, the adoption rate remains low. The objective of this study was to gain insight into the factors affecting the adoption of agricultural field robotics and UAVs using a systematic literature review approach that analyzed 23 relevant studies identified from two scientific databases (i.e., Web of Science and Scopus). Data regarding methodological aspects and results were extracted. Even though the current adoption of agricultural robots and UAVs is still limited, farmers seem highly interested. Most studies have used a quantitative approach to study the intention to adopt or the adoption of robotics or UAVs. Surprisingly, few studies have used an existing theory to explain the (intended) adoption. Age, gender, income, education, farm size, perceived usefulness, expected economic and environmental benefits, an attitude of confidence, and the perceived ease of use have been the internal factors most often identified. Meanwhile, the price of the technology, compatibility with other software and equipment, and labor scarcity are the most important external factors.
Fatal vanishing bile duct syndrome in Iranian patient with Hodgkin's lymphoma
Authors: Shokri Fazlollah , Shariati Aref , Veisari Arash Kazemi , Kianezhad Amirhossein , Sheidaei Somayeh , Alamian Ali Asghar , Sadeghi Hossein , Heidary Mohsen
Published: July 2023

Key Clinical Message

Vanishing bile duct syndrome (VBDS) has been postulated that may be related to Hodgkin's lymphoma (HL). In the present study, we present a 75‐year‐old male patient with HL who received chemotherapy but has not received any radiotherapy. The patient's condition worsened in further days, and he died with the diagnosis of cirrhosis and hepatic failure.
The influential capacity of carbon neutrality environmental orientation in modulating stakeholder engagement toward green manufacturing
Authors: Guo Hailan , Dong Ming , Tsinopoulos Christos , Xu Mengyuan
Published: July 2023

In response to the urgency for carbon neutrality and the dwindling of natural resources, a global pivot toward green manufacturing (GM) is underway. This study scrutinizes the operationalization of GM, assessing the impact of stakeholder engagement (SE) on the adoption of such practices, with a carbon neutrality environmental orientation (EO) as a moderating factor. Initial steps of this investigation incorporated a comprehensive analysis of extant literature, elucidating the tripartite constructs of green manufacturing (GM), SE, and carbon neutrality EO. Guided by the tenets of the NRBV and stakeholder theory, a conceptual framework was constructed to theoretically interlink these constructs. Subsequently, a Q‐sort pilot study was employed to preliminarily test and ascertain the validity and reliability of the proposed measurement tools before their incorporation into a broader survey. Data from 374 completed questionnaires, by managerial personnel, were analyzed using structural equation modeling to confirm the hypotheses. Empirical results substantiate that SE positively influences GM. Additionally, a carbon neutrality orientation moderates the SE–GM relationship. These findings possess significant implications for policymakers and firms within the apparel industry. By revealing the prevailing strengths and potential shortcomings in the current implementation of GM, this study underscores the imperative of robust SE and a committed EO toward carbon neutrality. Such a commitment can facilitate a more systematic and efficient enhancement of the GM process, from its nascent stages through to its complete realization.
Rationale and design of ENDEAVOR: A sequential phase 2b–3 randomized clinical trial to evaluate the effect of myeloperoxidase inhibition on symptoms and exercise capacity in heart failure with preserved or mildly reduced ejection fraction
Authors: Lund Lars H. , Lam Carolyn S.P. , Pizzato Patricia E. , Gabrielsen Anders , Michaëlsson Erik , Nelander Karin , Ericsson Hans , Holden Julie , Folkvaljon Folke , Mattsson Andrea , Collén Anna , Aurell Malin , Whatling Carl , Baldus Stephan , Drelich Grzegorz , Goudev Assen , Merkely Béla , Bergh Niklas , Shah Sanjiv J.
Published: July 2023

Aims

Mitiperstat (formerly AZD4831) is a novel selective myeloperoxidase inhibitor. Currently, no effective therapies target comorbidity‐induced systemic inflammation, which may be a key mechanism underlying heart failure with preserved or mildly reduced ejection fraction (HFpEF/HFmrEF). Circulating neutrophils secrete myeloperoxidase, causing oxidative stress, microvascular endothelial dysfunction, interstitial fibrosis, cardiomyocyte remodelling and diastolic dysfunction. Mitiperstat may therefore improve function of the heart and other organs, and ameliorate heart failure symptoms and exercise intolerance. ENDEAVOR is a combined, seamless phase 2b–3 study of the efficacy and safety of mitiperstat in patients with HFpEF/HFmrEF.

Methods

In phase 2b, approximately 660 patients with heart failure and ejection fraction >40% are being randomized 1:1:1 to mitiperstat 2.5 mg, 5 mg or placebo for 48 weeks. Eligible patients have baseline 6‐min walk distance (6MWD) of 30–400 m with a <50 m difference between screening and randomization and Kansas City Cardiomyopathy Questionnaire total symptom score (KCCQ‐TSS) ≤90 points at screening and randomization. The dual primary endpoints are change from baseline to week 16 in 6MWD and KCCQ‐TSS. The sample size provides 85% power to detect placebo‐adjusted improvements of 21 m in 6MWD and 6.0 points in KCCQ‐TSS at overall two‐sided alpha of 0.05. Safety is monitored throughout treatment, with a focus on maculopapular rash. In phase 3 of ENDEAVOR, approximately 820 patients will be randomized 1:1 to mitiperstat or placebo.

Conclusion

ENDEAVOR is the first phase 2b–3 study to evaluate whether myeloperoxidase inhibition can improve symptoms and exercise capacity in patients with HFpEF/HFmrEF.
Microbiota, diet, and the gut–brain axis in multiple sclerosis and stroke
Authors: Diaz‐Marugan Laura , Kantsjö Johan B. , Rutsch Andrina , Ronchi Francesca
Published: July 2023

Intestinal microbiota can influence the phenotype and function of immune cell responses through the dissemination of bacterial antigens or metabolites. Diet is one of the major forces shaping the microbiota composition and metabolism, contributing to host homeostasis and disease susceptibility. Currently, nutrition is a complementary and alternative approach to the management of metabolic and neurological diseases and cancer. However, the knowledge of the exact mechanism of action of diet and microbiota on the gut–brain communication is only developing in recent years. Here, we reviewed the current knowledge on the effect of diet and microbiota on the gut–brain axis in patients with two different central nervous system diseases, multiple sclerosis and stroke. We have also highlighted the open questions in the field that we believe are important to address to gain a deeper understanding of the mechanisms by which diet can directly or indirectly affect the host via the microbiota. We think this will open up new approaches to the treatment, diagnosis, and monitoring of various diseases.
A multi‐objective optimization approach to designing window and shading systems considering building energy consumption and occupant comfort
Authors: Nazari Sarah , Keshavarz Mirza Mohammadi Payam , Sareh Pooya
Published: July 2023

The energy performance of a building has a significant impact on the environment as well as the comfort of its occupants. Given that window systems and control elements such as shading devices play a critical role in a building's energy consumption and comfort, this article presents an investigation into the optimization of windows in four different orientations, along the four cardinal directions, for a typical office room in Tehran. The objective is to reduce cooling, heating, and lighting energy consumption while improving occupant comfort simultaneously, using the NSGA‐II algorithm as a multi‐objective optimization method. To this end, first, an investigation into the effects of various parameters on total building energy consumption and occupant comfort is conducted. Subsequently, each parameter is evaluated in detail concerning its impact on each façade. As the final step, for each façade, the optimal solutions and the most undesirable scenarios are determined. The results, in which the possibility of glare is also considered, can be used by architects and designers for making informed design decisions. The results show that, in all orientations, the number of slats and their distance from the wall are the most effective parameters of shading configurations. Although the eastern and western windows are larger in this study, visual discomfort can be controlled using suitable shadings to achieve acceptable levels of visual comfort. Furthermore, north façades provide the least amount of thermal comfort and consume the least amount of energy while experiencing glare for longer periods.
Biolistic transformation of the yeast Saccharomyces cerevisiae mitochondrial DNA
Authors: Veloso Ribeiro Franco Leticia , Barros Mario H.
Published: July 2023

The insertion of genes into mitochondria by biolistic transformation is currently only possible in the yeast Saccharomyces cerevisiae and the algae Chlamydomonas reinhardtii. The fact that S. cerevisiae mitochondria can exist with partial (ρ− mutants) or complete deletions (ρ0 mutants) of mitochondrial DNA (mtDNA), without requiring a specific origin of replication, enables the propagation of exogenous sequences. Additionally, mtDNA in this organism undergoes efficient homologous recombination, making it well‐suited for genetic manipulation. In this review, we present a summarized historical overview of the development of biolistic transformation and discuss iconic applications of the technique. We also provide a detailed example on how to obtain transformants with recombined foreign DNA in their mitochondrial genome.
The impact of anti‐corruption on environmental governance efficiency in China: A study based on spatial effect
Authors: Hou Hui , Yang Siwei , Zhang Minghao
Published: July 2023

Anti‐corruption is an important initiative in China's national governance system. The existing literature usually studies the direct impact of corruption or anti‐corruption on China's environment, while few studies show the spatial correlation impact of anti‐corruption on China's environmental governance. This paper redefines anti‐corruption, uses panel data of 30 Chinese provinces and cities from 2005 to 2019, and empirically analyzes the impact of anti‐corruption on environmental governance efficiency in China using spatial Durbin model. The findings indicate that the direct effect of anti‐corruption on environmental governance efficiency is positive, indicating that increasing anti‐corruption efforts will help improve local environmental governance efficiency; indirect effect of anti‐corruption on environmental governance efficiency is negative, suggesting that due to the existence of “pollution heaven” effect, the strengthening of anti‐corruption in the local region will cause polluting industries to move from local region to neighboring regions, leading to serious environmental pollution in the neighboring regions, and then reducing environmental governance efficiency. The indirect effect of economic development, industrial structure, and economic openness are negative, while the indirect effect of urbanization rate and clean energy are positive. The findings of the study provide a theoretical basis and insight for governments at all levels to improve environmental governance efficiency through anti‐corruption.
Bilateral extended FDK: An improved weighting method for static CT imaging
Authors: Zha Keyang , Zhao Qingxian , Luo Shouhua , Li Yunxiang
Published: July 2023

Background

Improving imaging speed has always been the focus of research in CT technology, which is related to the radiation dose and imaging quality of moving organs, including heart and blood vessels. However, it is difficult to achieve further improvement by increasing the rotation speed of the gantry due to its structural strength limitation. Differing from the conventional CTs, the static CT employs dozens of ray sources to acquire projection data from different angular ranges, and each source only needs to be rotated in a small range to finish a full 360° scan, thus greatly increasing the scanning speed.

Purpose

As sources of static CT need to be evenly distributed over 360°, the sources and detectors have to be arranged on two parallel rings independently. Such a geometry can be considered as a special case of CT systems with a significantly large cone angle, that is, a part of the detector is missing in the vicinity of the mid‐plane. Due to restriction of upper and lower bounds of the cone angle of the static CT, there are uneven projection data varying in each portion of the reconstruction volume, the conventional analytical or iterative reconstruction methods may introduce artifacts in the reconstructed outcomes.

Methods

Following the weighting approach extended FDK (xFDK) by Grimmer et al., we propose an improved bilateral xFDK algorithm (bixFDK), which focuses on the reconstruction of the expanded volume. With the same philosophy as xFDK in terms of weighting function design, bixFDK takes the longitudinal offset of the detector with respect to the source into consideration, making our method applicable to a wide range of CT geometries, especially for the static CT. Based on the proposed bixFDK, a new iterative scheme bixFDK‐IR is also constructed to extend the applications to a wide range of scan protocols such as sparse‐view scan.

Results

The proposed method has been validated with the simulated phantom data and the actual clinical data of the static CT, and demonstrates that it can ensure good image quality and enlarge the reconstruction volume in z‐direction of the static CT.

Conclusions

The bixFDK algorithm is an ideal reconstruction approach for static CT geometry, and the iterative scheme of bixFDK‐IR is applicable to a wide range of CT geometries and scan protocols, thus providing a wide range of application scenarios.
Atomic‐Scale Observations of the Immiscible Melted Metals Confined in a Single‐Atom Layer
Authors: Bondarenko Leonid V. , Tupchaya Alexandra Y. , Utas Tatiana V. , Vekovshinin Yurii E. , Gruznev Dimitry V. , Mihalyuk Alexey N. , Eremeev Sergey V. , Zotov Andrey V. , Saranin Alexander A.
Published: July 2023

Elucidating how changing of the dimensionality affects the property of the matter is the key challenge problem of the nanoscience. In particular, it has recently been reported that 2D liquids have fundamentally different dynamic properties to 3D liquids. Herein, the ultimate physical limit is addressed, when the liquid is confined to a single‐atom layer. The case has been realized with the Tl–Pb alloy layer grown on Si(111) substrate terminated by a single‐layer . At room temperature, the alloy behaves as a system of the immiscible melted metals confined in a single‐atom layer. In the scanning tunneling microscopy observation, Tl and Pb arrays have different contrasts that allows a direct visualization of evolution of the forming structures within atomic layer, as a function of the time and layer composition. In particular, it has been found that the structures look much like the Turing patterns. The obtained experimental dataset, especially the recorded STM videos, is believed to provide a hint for the prospective theoretical understanding of the dynamics of the single‐atom‐thick liquids.
Imidazole‐hydrazone derivatives: Synthesis, characterization, X‐ray structures and evaluation of anticancer and carbonic anhydrase I–II inhibition properties
Authors: Ünver Hakan , Acar Cevik Ulviye , Bostancı Hayrani Eren , Kaya Oğuzhan , Kocyigit Ümit M.
Published: July 2023

The nine new imidazole‐hydrazone derivatives of Schiff base were synthesized from the condensation reactions of 1‐methyl‐1H‐imidazole‐2‐carbaldehyde with various substituted‐hydrazide derivatives. Structures of the final compounds (1 a–1 i) were characterized by using 1H NMR, 13C NMR spectroscopic techniques, elemental analysis, and crystal X‐ray diffraction. The in vitro carbonic anhydrase I and II potentials of these synthesized were evaluated. The result suggests that compound 1 a, a 4‐methoxy substituted analog with an IC50 of 0.949 μM, was found to have the most potent hCA I inhibitory activity. Compounds 1 c, 1 d, and 1 h were the most potent compounds on hCA II with IC50 values of 3.330, 4.454, and 5.66 μM, respectively. All compounds were examined for their cytotoxicity towards human colorectal adenocarcinoma cell (HT29) and rat glioma cell line (C6) compared to mouse fibroblast normal cell line (L929) using the MTT assay method. The compounds 1 a, 1 d, and 1 i exhibited significant antiproliferative activity with less toxicity to a health cell line. Consequently, compound 1 a could be the potential lead for emerging selective cytotoxic compounds directing hCA I. Compound 1 d could be the potential lead for emerging selective cytotoxic compounds directing hCA II.
Nanomedicines for Improved Management of Ectopic Pregnancy: A Narrative Review
Authors: Moses Abraham S. , Korzun Tetiana , Mamnoon Babak , Baldwin Maureen K. , Myatt Leslie , Taratula Oleh , Taratula Olena R.
Published: July 2023

Ectopic pregnancy (EP) – the implantation of an embryo outside of the endometrial cavity, often in the fallopian tube – is a significant contributor to maternal morbidity and leading cause of maternal death due to hemorrhage in first trimester. Current diagnostic modalities including human chorionic gonadotropin (hCG) quantification and ultrasonography are effective, but may still misdiagnose EP at initial examination in many cases. Depending on the patient's hemodynamic stability and gestational duration of the pregnancy, as assessed by history, hCG measurement and ultrasonography, management strategies may include expectant management, chemotherapeutic treatment using methotrexate (MTX), or surgical intervention. While these strategies are largely successful, expectant management may result in tubal rupture if the pregnancy does not resolve spontaneously; MTX administration is not always successful and may induce significant side effects; and surgical intervention may result in loss of the already‐damaged fallopian tube, further hampering the patient's subsequent attempts to conceive. Nanomaterial‐based technologies offer the potential to enhance delivery of diagnostic imaging contrast and therapeutic agents to more effectively and safely manage EP. The purpose of this narrative review is to summarize the current state of nanomedicine technology dedicated to its potential to improve both the diagnosis and treatment of EP.
Neutral MOF Anion Receptor: Radical‐Promoted Precise Anion Recognition
Authors: Dong Shuyu , Yu Zhiwu , Guo Liecheng , Yang Yuting , Tu Changzheng , Krishna Rajamani , Luo Feng
Published: July 2023

Precise ion recognition plays a key role in the anionic decontamination in water. However, the established anionic recognition based on neutral or cationic anion receptor is still restricted by the inherent limitation, such as narrow application scope in organic solvent rather than water for neutral anion receptor and poor selectivity due to non‐directional electrostatic interaction for cationic anion receptor. Herein, for the first time, a neutral metal–organic framework (MOF) anion receptor is shown, enabling precise anion recognition, for example, the presence of a variety of 1000‐fold competitive anions does not affect the selective adsorption of the target anion at all. A radical‐dominating anion‐recognition mechanism is proposed for rationalizing the efficacy of the neutral MOF.