bluuebunny/crossref_metadata_2025 huggingface dataset:
The value of diagnostic vitrectomy: Histocytopathology techniques for the diagnosis of lymphoma of the retina
Authors: Provenzano Giovanna , Burnier Julia Valdemarin , Bergeron Sabrina , Youhnovska Emma , Marcotte Emily , Chen John , Sun Vincent , Burnier Miguel Noel
Published: February 2024

Purpose:

Primary large B-cell lymphoma of the retina, vitreous, and central nervous system (CNS), is an intraocular tumor with an unspecific and insidious clinical presentation. Pars plana vitrectomy (PPV) and optical coherence tomography (OCT) are useful diagnostic tools for this malignant process. The aim of this study is to evaluate the diagnostic efficacy of PPV for these intraocular lesions under a modified diagnostic protocol with a clinical pathological correlation with OCT imaging.

Materials and Methods:

A total of 115 samples were collected after a vitrectomy procedure (aspiration or vitrectomy cassette). The samples were centrifuged, and the precipitates were collected. A cell block was prepared and analyzed with multiple stains and an immunohistochemistry (IHC) panel, including B- and T-cell markers, as well as light chain markers, to establish the monoclonal nature of the tumor. Of the 115 samples, 9 (7.83%) were diagnosed with large B-cell lymphoma of the retina, vitreous, and CNS.

Conclusion:

Diagnostic vitrectomies for the large B-cell lymphoma of the retina, vitreous, and CNS is an excellent tool for the diagnosis of this entity. A negative diagnostic PPV with a strong suspicious OCT image, where the neoplastic cells are located between the retinal pigmented epithelium and Bruch’s membrane, the latter procedure should be either repeated or a chorioretinal biopsy be performed. In contrast, a positive vitrectomy using the IHC panel for large B-cell lymphoma of the retina, vitreous, and CNS is pathognomonic of this condition. In addition, the OCT is an important tool to help in the diagnosis of this difficult entity.

Results:

The diagnostic PPV provided suitable vitreous samples to all patients with undetermined uveitis and/or intraocular tumor suspicion. A morphological and immunohistichemical (IHC) analysis enabled a conclusive diagnosis of retina, vitreous and CNS lymphoma in all patients submitted to the procedure.
Diabetic papillopathy: A rare ocular manifestation of diabetes mellitus
Authors: Aguiar Catarina Pestana , Jesus Jeniffer Domingues , Chibante-Pedro João C. M. , Rocha António G.
Published: February 2024

Diabetic papillopathy (DP) is a rare ocular manifestation of diabetes mellitus. The exact etiology is not well understood, but in some cases, it may be associated with a rapid correction of the blood glucose level. There are limited case reports describing the use of intravitreal anti-vascular endothelial growth factor antibodies which have shown effectiveness in reducing disc swelling. In this case, we present the case of an 80-year-old diabetic woman diagnosed with DP during a diabetic retinopathy (DR) screening. Her visual acuity (VA) was counting fingers on her right eye and 20/160 on her left eye. At the fundoscopy, an exuberant bilateral hemorrhagic disc edema was observed, along with a nonproliferative DR. This edema was also evident in the fluorescein angiography and was documented through the optical coherence tomography. Brain computed tomography normal. She was treated with ranibizumab with significant improvement of the optic disc edema and the VA.
Efficacy and safety of chinese herbal medicines combined with chemical drugs for alzheimer's disease: A systematic review and meta-analysis
Authors: Xu Li , Chen Wen-Jun , Tian Cai-Jun , Zhang Yan , Ma Yan , Li Tian-Hao , Liu Hong-Jie , Zhang Zhe
Published: February 2024

Objective:

To evaluate the efficacy and safety of Chinese herbal medicines (CHMs) combined with chemical drugs for the treatment of Alzheimer's disease (AD).

Materials and Methods:

Databases were searched to retrieve randomized controlled trials (RCTs) of CHMs combined with tacrine, galantamine, rivastigmine, donepezil, or memantine, following strict inclusion and exclusion criteria. Only research papers published in English, Chinese, and Japanese were considered. The primary outcome was the mini-mental state examination (MMSE) score and the secondary outcomes were AD assessment scale cognitive subscale (ADAS-Cog) score and safety evaluation. Meta-analysis was carried out using RevMan 5.3 and subgroup analysis was conducted to identify the sources of heterogeneity.

Results:

A total of 15 RCTs with 1386 participants were included in this study. Only donepezil was used in the retrieved literature. Meta-analyses showed that the combination of CHMs with donepezil led to significant improvement in the MMSE score (Z = 9.45; P < 0.00001; weighted mean difference [WMD] =2.68, 95% confidence interval [CI]: 2.12–3.24) and a significant decrease in the ADAS-Cog score (Z = 5.53; P < 0.00001; WMD = −3.79; 95% CI: −5.13–−2.44). Safety evaluation demonstrated that these combination treatments relieved adverse events such as insomnia (risk ratio [RR] =0.20, 95% CI: 0.06–0.68; P = 0.01) and hive (RR = 0.10; 95% CI: 0.01–0.73; P = 0.02).

Conclusions:

The combination of CHMs with a chemical drug like donepezil led to significant improvements in patient cognition as well as a better safety profile when compared to the application of a chemical drug alone.
Mechanism of mingjing granules in treating wet age-related macular degeneration based on network pharmacology and experimental verification
Authors: Li Xiao-Yu , Liang Li-Na , Zhang Wei-Jun , Gao Yun , Chen Qiang
Published: February 2024

Objective:

To analyze the potential mechanism of Mingjing granules in the treatment of wet age-related macular degeneration (wAMD) based on the research methods of network pharmacology and molecular docking approach and to provide a new reference for the currently limited treatment of wAMD.

Materials and Methods:

We searched TCMSP, GeneCards, OMIM, PharmGkb, TTD, and DrugBank database to screen the main active ingredients of Mingjing granules and their therapeutic targets of wAMD. The network of active components and targets was constructed using Cytoscape3.6.1 software, which was also used for the topological analysis of target genes. The network of Protein-Protein Interactions (PPI) was mapped using the String platform. We also used R language to do the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway for additional analysis. Molecular docking studies were finished by Chemoffice, Autodock, and Pymol. Finally, the efficacy of the Mingjing granules was examined in animal experiments, in which we used enzyme-linked immunosorbent assay to the contents of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) levels in peripheral blood.

Results:

Active compounds, including quercetin, lignocaine, and kaempferol, were found. PPI network analysis showed that tumor necrosis factor (TNF), MMP-9, epidermal growth factor (EGF), prostaglandin-endoperoxide synthase 2 (PTGS2), and caspase-3 (CASP3) were related to both Mingjing granules and wAMD. GO and KEGG pathway analysis showed that these targets were mainly involving lipids and atherosclerosis, TNF, and interleukin-17 (IL-17) signaling pathways. Docking studies suggested that quercetin and luteolin can fit in the binding pocket of four target proteins (CASP3, EGF, PTGS2, and TNF). In the vivo experiment, the Mingjing granules were found to be effective on the expression of VEGF and MMP-9 in peripheral blood.

Conclusions:

This study initially reveals the multi-constituent, multi-target, and multi-pathway mechanism of action of Mingjing granules in the treatment of wAMD and implies the inhibition of choroidal neovascularization may be related to the expression of VEGF and MMP-9.
Biological Mechanism of Traditional Chinese Medicine Formula and Herbs in Treating Diseases from the Perspective of Cold and Hot
Authors: Wang Bo-Yang , Chen Pan , Zhang Peng , Li Shao
Published: February 2024

Cold and Hot syndrome, also known as “ZHENG” in Mandarin, is a fundamental theory in traditional Chinese medicine (TCM) and plays a pivotal role in the differentiation of diseases in TCM. Diseases are treated with varying formulas according to the specific syndrome differentiations in TCM. A way of the principles followed in TCM medical strategy is “cold herbs for hot syndrome, and hot herbs for cold syndrome.” Therefore, from the perspective of cold/hot syndrome, we summarizes the present research regarding the characteristics and mechanisms of cold/hot herbs (including herbs with cool and warm properties) in digestive system diseases, respiratory diseases, and autoimmune diseases, among others. As novel technologies have advanced, various methods, such as those based on network target, machine learning, and deep learning, have emerged to reveal the mechanisms underlying cold/hot syndrome and cold/hot herbs. With the help of these technologies, it has been found that cold and hot herbs, as well as formulae with cold or hot intentions, have similarities and differences in the treatment of these diseases. In conclusion, cold and cool may have stronger antibacterial, antiviral, and anti-inflammatory effects, whereas hot and warm herbs may specifically enhance immune regulation. With the assistance of advancing data algorithms, uncovering the mechanisms of cold/hot herbs may accelerate and provide a new research paradigm for further achieving precision in TCM.
Network pharmacology-based dissection of the bioactive compounds and pharmacological mechanisms of yiqi fumai lyophilized injection for the treatment of heart failure
Authors: Huang Yu-Xi , Fan Jing-Jing , Xu Lu-Lu , Yu Rong , Kuang Yi , Chai Yue , Zheng Rui , Zhang Xiao-Yu , Shan Hong-Cai , Qiao Xue , Ye Min
Published: February 2024

Objective:

Yiqi Fumai Lyophilized Injection (YQFM), a Chinese medicine injection, has been widely used for the treatment of cardiovascular diseases, especially heart failure (HF). However, bioactive compounds and underlying mechanisms of YQFM in treating HF remain poorly understood.

Materials and Methods:

Network pharmacology was employed to investigate the bioactive compounds and mechanisms of YQFM. A compound-target network was constructed to screen bioactive compounds based on contribution index calculation. Then, an adriamycin-induced HF rat model was established to evaluate the cardio-protective effects of YQFM by hematoxylin and eosin staining and enzyme-linked immunosorbent assays.

Results:

Network pharmacology indicated that YQFM may alleviate HF through 36 compounds and 109 targets. Particularly, ginsenosides Rb1, Rg1, Re, Rf, Rb2, Rh1, schisandrin, and ginsenoside Rc were indicated as the top contributors of YQFM in treating HF. YQFM was predicted to act on multiple targets such as vascular endothelial growth factor A, interleukin-2 (IL-2), IL-6, and IL-1β, as well as to regulate signaling pathways such as hypoxia-inducible factor 1, tumor necrosis factor, VEGF, and PI3K-Akt. The pharmacological study suggested that YQFM could attenuate cardiac injury and up-regulate plasma concentrations of VEGFR-1 and NO in HF rats. Ginsenoside Rb1, as the major contributor from network pharmacology analysis, also showed a cardioprotective effect and up-regulation of VEGFR-1 in plasma.

Conclusions:

Ginsenosides and schisandrin were predicted as the most important contributors to the cardioprotective effect of YQMF. Ginsenoside Rb1 was proved to alleviate HF and increase the plasma concentration of VEGFR-1.
Deep learning-based lung nodule detection: a review
Authors: Zhou Feifei
Published: February 2024

CT scan acquisition is fast and cost-effective and has become the main lung imaging tool. However, the increase in large numbers of CT scans has placed a heavy burden on radiologists; therefore, automated lung nodule detection techniques are needed to reduce the workload of radiologists and computer-aided detection systems are proposed for further accurate diagnosis of the condition. This review provides a comprehensive overview of recent automated lung nodule detection techniques and challenges, etc., as well as a detailed overview and discussion of current research gaps, future developments, and research trends. Relevant articles published in databases such as IEEE Xplore, Science Direct, PubMed, and Web of Science cover research algorithms published from 2014 to 2023, mainly discussing deep learning-based techniques. The schemes presented in these articles, the databases used, the experimental results, and the performance of the algorithms are compared and discussed. This work aims to introduce researchers and readers to the latest techniques and their advances in the detection of lung nodules in the last decade, which will help researchers and radiologists to further understand the latest techniques in this field.
Impressive predictive model for Breast Cancer based on Machine Learning
Authors: Selvaraj Saravanakumar , Thangavel Saravanan , Prabhakaran M , Sathish T
Published: February 2024

INTRODUCTION: Breast cancer is a major health concern for women all over the world.
OBJECTIVES: In order to reduce mortality rates and provide the most effective treatment, Histopathology image prognosis is essential. When a pathologist examines a biopsy specimen under a microscope, they are engaging in histopathology. The pathologist looks for the picture, determines its type, labels it, and assigns a grade.
METHODS: Tissue architecture, cell distribution, and cellular form all play a role in determining whether a histopathological scan is benign or malignant. Manual picture classification is the slowest and most error-prone method. Automated diagnosis based on machine learning is necessary for early and precise diagnosis, but this challenge has prevented it from being addressed thus far. In this study, we apply curvelet transform to a picture that has been segmented using k-means clustering to isolate individual cell nuclei.
RESULTS: We analysed data from the Wisconsin Diagnosis Breast Cancer database for this article in the context of similar studies in the literature.
CONCLUSION: It is demonstrated that compared to another machine learning algorithm, the IICA-ANN IICA-KNN and IICA-SVM-KNN method using the logistic algorithm achieves 98.04% accuracy.
Prediction of User Attrition in Telecommunication Using Neural Network
Authors: N Mageshkumar , A Vijayaraj , Chavva Subba Reddy , Senthilvel Gururama
Published: February 2024

INTRODUCTION: The telecommunications industry faces significant challenges due to customer attrition, which directly impacts revenue. To better understand and address this issue, Companies are looking into techniques to determine the internal issues that affect customer churn.
OBJECTIVES: This article offers an overview of customer attrition within the telecommunications sector.
METHODS: It introduces an advanced churn prediction model harnessing state-of-the-art technologies, including neural networks, machine learning, and other cutting-edge innovations, to achieve remarkably high accuracy rates. By analyzing diverse parameters and datasets collected from multiple telecom companies, valuable insights can be gained.
RESULTS: The model's performance on test data can be evaluated using metrics such as Accuracy Score, Area under Curve (AUC), Sensitivity, Specificity, and other performance indicators.
CONCLUSION: In order to effectively manage extensive datasets, organizations can leverage Big Data technology. This empowers them to forecast the probability of customer churn and put in place proactive strategies to retain their customer base.
Linear progress in fibres
Authors: Gadre Vaibhav , Hensel Sebastian
Published: February 2024

A fibred hyperbolic 3-manifold induces a map from the hyperbolic plane to hyperbolic 3-space, the respective universal covers of the fibre, and the manifold. The induced map is an embedding that is exponentially distorted in terms of the individual metrics. In this article, we begin a study of the distortion along typical rays in the fibre. We verify that a typical ray in the hyperbolic plane makes linear progress in the ambient metric in hyperbolic 3-space. We formulate the proof in terms of some soft aspects of the geometry and basic ergodic theory. This enables us to extend the result to analogous contexts that correspond to certain extensions of closed surface groups. These include surface group extensions that are Gromov hyperbolic, the universal curve over a Teichmüller disc, and the extension induced by the Birman exact sequence.
Effective Sato–Tate conjecture for abelian varieties and applications
Authors: Bucur Alina , Fité Francesc , Kedlaya Kiran S.
Published: February 2024

From the generalized Riemann hypothesis for motivic

L

-functions, we derive an effective version of the Sato–Tate conjecture for an abelian variety

A

defined over a number field

k

with connected Sato–Tate group. By
effective
we mean that we give an upper bound on the error term in the count predicted by the Sato–Tate measure that only depends on certain invariants of 

A

. We discuss three applications of this conditional result. First, for an abelian variety defined over

k

, we consider a variant of Linnik’s problem for abelian varieties that asks for an upper bound on the least norm of a prime whose normalized Frobenius trace lies in a given interval. Second, for an elliptic curve defined over 

k

with complex multiplication, we determine (up to multiplication by a nonzero constant) the asymptotic number of primes whose Frobenius traces attain the integral part of the Hasse–Weil bound. Third, for a pair of abelian varieties

A

and

A'

defined over

k

with no common factors up to

k

-isogeny, we find an upper bound on the least norm of a prime at which the respective Frobenius traces of

A

and

A'

have opposite sign.
Cattle tick-borne pathogens sharing the same vectors in Benin and Burkina Faso: variations in prevalence and coinfection patterns
Authors: Biguezoton Abel S. , Adehan Safiou B. , Adakal Hassane , Badolo Honorine , Toure Mamadou , Zoungrana Sebastien , Farougou Souaibou , Chevillon Christine
Published: February 2024

Understanding interactions between pathogens at the level of the individual host and the population in West Africa, may have  noteworthy implications for predictions of diseases emergence and disease control programmes. Hence, the current study was aimed at  investigating the interactions between Anaplasma marginale, Babesia bigemina and B. bovis in West African cattle. Twelve sentinel steers  in each of the eight selected herds were randomly chosen to perform a one-year-long survey designed to monthly collect blood  sample and to diagnose possible infections of the steers. This allowed identifying A. marginale as the most prevalent pathogen across the  three surveyed regions (range: 0.60-1), followed by B. bigemina (0.24-0.85) and B. bovis (0.10-0.64); the same ranking order of the  tick-borne pathogens was observed when considering the apparent duration of cattle infection. Regarding interaction patterns, mainly  avoidance was revealed between A. marginale and B. bigemina and between B. bigemina and B. bovis. Such negative interaction seemed  to be beneficial to the West African cattle surveyed, helping them to escape from babesiosis caused by B. bovis. Altogether, studied Boophilus tick-borne pathogens negatively interact within cattle in Benin and Burkina Faso. This pattern raises new questions regarding  the underlying mechanisms and potential consequences.
Risques sanitaires liés à la qualité physico-chimique et bactériologique de l’eau de source souterraine d’Igaga, Fianarantsoa (Madagascar)
Authors: Rabearisoa Andry Harinaina , Harinandrasana Viviane , Rabearisoa Hajandrainy , Rakotozafy Jean Claude Richard , Razanamparany Bruno , Randimbiarison Sedravola Nasolo
Published: February 2024

L'eau, une ressource vitale, est étudiée pour évaluer les risques sanitaires liés à sa qualité dans la ville de Fianarantsoa, Madagascar. En  mars 2023, des analyses ont été réalisées sur des échantillons d'eau prélevés à Igaga, incluant des mesures physico-chimiques telles que  la température, le pH, la conductivité électrique, les solides totaux dissous, la turbidité, la demande biologique en oxygène sur cinq jours,  le taux d'ion chlorure, ainsi que des analyses bactériologiques couvrant les coliformes totaux et le streptocoque fécaux par la méthode  de filtration sur membrane. Les résultats obtenus ont montré que les échantillons prélevés présentaient une valeur moyenne de turbidité  9,19 NTU dépassant la norme établie, ils ont été faiblement minéralisés avec la valeur moyenne de conductivité 130,5 µS/cm et  légèrement acide. De plus les eaux ont été contaminées par des germes bactériologiques de coliforme totaux en 38,50 colonies/100 ml  en moyenne et streptocoques fécaux en 43 colonies /100 ml en moyenne. En conclusion, l'eau de source d'Igaga présentait des risques  potentiels pour les utilisateurs, particulièrement en ce qui concerne les maladies d'origine hydrique. Cette augmentation des germes fécaux pourrait être attribuée au ruissellement après la saison des pluies et au manque d'assainissement et d'hygiène dans  l'environnement de la source. 

 

English title: Health risk related to the physic-chemical and bacteriological quality of groundwater Igaga Fianarantsoa (Madagascar)

Water, a vital resource, is being studied to assess health risks associated with its quality in the city of Fianarantsoa, Madagascar. In March  2023, analyses were conducted on water samples collected in Igaga, including physico-chemical measurements such as temperature, pH,  electrical conductivity, total dissolved solids, turbidity, five-day biochemical oxygen demand, chloride ion concentration, as well as  bacteriological analyses covering total coliforms and fecal streptococci using the membrane filtration method. The results showed that  the sampled water had an average turbidity value of 9.19 NTU, exceeding the established standard. They were weakly mineralized with an  average conductivity value of 130.5 µS/cm and slightly acidic. Furthermore, the water was contaminated with bacteriological germs,  with an average of 38.50 colonies/100 ml for total coliforms and 43 colonies/100 ml for fecal streptococci. In conclusion, Igaga's spring  water presented potential risks for users, particularly regarding waterborne diseases. This increase in fecal germs could be attributed to  runoff after the rainy season and the lack of sanitation and hygiene in the source environment.
Treatment of intellectual property in the bankruptcy legal framework of the GCC states
Authors: Malkawi Bashar , Almajed Bashayer
Published: February 2024

The Gulf Cooperation Council (GCC) states have made a number of efforts to reform bankruptcy laws in recent years. The modernization of bankruptcy law in GCC countries presents the question of how IP assets and bankruptcy proceedings relate and intertwine. Problems for insolvency proceedings centre on valuation. An even more complicated but extremely common scenario is when the IP is licensed. Licensing effectively creates a new ‘sub-bundle’ of rights from the original property rights. Another issue is the classification of a licence and whether it is a property right or a contractual right, or some type of hybrid creature. Complications are exacerbated by the fact that many IP licence agreements will contain an ipso facto clause. The purpose of this article is to address these issues by examining the laws of the UAE, Kuwait and Saudi Arabia, and how IP assets are treated in bankruptcy proceedings.
A Critical Review on Conservation of Rural Architecture and Life in Turkey: Visions, Tools, and Organizations
Authors: KURTULUŞ Vacide Betül , ŞAHİN GÜÇHAN Neriman
Published: February 2024

Once a vibrant fabric of life, rural Turkey is facing a significant problem with population loss today. With changes in policies and the declining attractiveness of rural areas, rural architecture and lifestyles are in danger of disappearing. This study explores the complexities of this crisis, going beyond the mere preservation of buildings. It analyzes agricultural, legal, and administrative policies that trigger migration from rural areas and examines international frameworks. Beyond preserving buildings, the study delves into the initiatives, responses, and values that are critical to the revitalization of rural life. The study assesses movements that have been initiated to empower local communities and sustain rural lifestyles, recognizing that the sustainability of rural life is dependent on a thriving community. In conclusion, safeguarding Turkey's rural heritage requires a transformative approach. By prioritizing local participation, fostering interconnected solutions, and addressing the existing limitations, a future of thriving rural communities and their cultural heritage becomes possible.
Inadequacies in Local Entrepreneurial Ecosystems that Impede Growth-Oriented Entrepreneurship in Lesotho
Authors: Obiahu Joseph Echem , Qutieshat Abubaker
Published: February 2024

Entrepreneurship is acknowledged globally as a driver of unemployment reduction, poverty alleviation and national economic well-being. However, many nations, especially developing ones, struggle to sustain growth-oriented entrepreneurship due to limitations in their entrepreneurial ecosystems. With an unemployment rate of 28.9% as of 2019, Lesotho is one of the countries struggling to sustain effective entrepreneurial ecosystems. This article seeks to identify the inadequacies in local entrepreneurial ecosystems that impede the emergence of entrepreneurs and small-and-medium enterprises in Lesotho. This study, grounded in systems theory, utilised a qualitative approach using semi-structured interviews to collect data from twenty-five budding entrepreneurs. Data analysis showed that financial institutions funding, entrepreneurial apathy, poor infrastructure, dearth of talents and leaders, and inadequate support networks were the main barriers to entrepreneurship in Lesotho. This study raises awareness of Lesotho's entrepreneurial ecosystem's basic flaws, which hinder growth-oriented business. The study is expected to improve policymakers’ intervention strategies and attract more scholars' attention to the phenomenon. The study is limited in scope due to the participants' concentration in Maseru, the capital city. This geographical restriction is a limitation to the extent that businesses operating in the city and those operating in the countryside may experience different systemic impacts. Future research should explore broader scope.
Processing of Starfruit (Averrhoa bilimbi L.) on the Acceptability of Sweets as a Snack Food for Hypercholesterol Sufferers: Study of Color, Taste and Aroma
Authors: Prabowo Agung , Irman Dede , Azahra Astrid Sulistya
Published: February 2024

This research aims to examine the acceptability of color, taste and aroma of candied starfruit (Averrhoa bilimbi L.) with three different formulations, namely fresh starfruit, dried candied and wet candied. The assessment was carried out by 30 trained panelists using the Hedonic Scale Scoring method. The analysis results show that there are significant differences in the acceptability of color and taste of sweets based on different formulations. Wet sweets (P3) received the highest assessment in all aspects, including color, taste and aroma. Although aroma plays an important role in determining the deliciousness of food, statistical test results show that sweet formulations do not significantly influence the perception of aroma by panelists. These results provide important insights in developing candied starfruit products that are more in line with consumer preferences.
Des sources aux données, concevoir une base de données en sciences humaines et sociales avec nodegoat
Authors: Cosovschi Agustín
Published: February 2024

Cette leçon permet de prendre en main le logiciel nodegoat pour construire une base de données relationnelle dans le cadre d'une recherche en sciences humaines.
Sedimentological and geochemical evaluation of sandstones of the Ilaro formation, Dahomey Basin, Southwestern Nigeria : Insights into paleoenvironments, provenance, and tectonic settings
Authors: Jimoh A. Y. , Saadu M. B. , Adetoro A. A. , Ajadi J. , Issa T. , Issa U.
Published: February 2024

Grain size analysis, geochemistry, and petrography of sandstones of the Ilaro Formation exposed at the Ajegunle area were investigated to infer provenance, transportation history, tectonic setting, paleoenvironment, and degree of palaeoweathering of the sediments. Selected sandstones were analyzed, and the major, trace, and rare earth elements were determined using Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Results from the granulometric analysis showed that sandstones were deposited in fluvial conditions. The sandstones exhibit a coarse-grained texture, displaying poor sorting and being texturally immature. The petrographic analysis indicated that quartz was predominant, whereas opaque minerals, muscovite, and ferruginous ground mass were present in smaller quantities. The sandstones can be geochemically classified as arkose and subarenite. The sandstones have an average composition of SiO2 (82.87%) and Al2O3 (9.49%), while K2O, Na2O, MgO, CaO, and P2O5 have <1% each. The elevated Al2O3 content is associated with the lithic fragment composition, whereas the low concentrations of MgO (mean 0.03%), Na2O (mean 0.008%), and K2O (mean 0.04%) suggest chemical destruction in an oxidizing environment. The angularity of the grains indicated a short transportation history very close to the provenance. Bivariate and discriminant plots from major elements and trace elements suggest the sandstones were non-marine and sourced from intermediate rocks. The sandstones were deposited in an oxic-dyoxic condition under a humid climate and passive or active continental margins. The average values of the weathering indices indicate an intense degree of chemical weathering.
Manual digital de dibujo artístico para el desarrollo de habilidades técnicas en los estudiantes del 4º año de la E.T.A.V. Martín Tovar y Tovar
Authors: Hern´andez José
Published: February 2024

El presente artículo bajo modalidad de informe de investigación, tiene como objetivo reportar el desarrollo de una investigación donde se propus un manual digital de dibujo artístico para el desarrollo de habilidades técnicas en los estudiantes del 4º año de la E.T.A.V. Martín Tovar y Tovar. El desarrollo de la investigación estuvo basado en el enfoque cuantitativo, paradigma positivista, bajo la modalidad de proyecto especial, apoyado en una investigación de campo con carácter descriptivo. Se desarrolló  en tres fases: la primera el diagnóstico a fin de determinar la necesidad de diseñar el manual digital, se tomaron como población el 30% de los estudiantes cursantes de 4to año de la mención arte puro del año escolar 2022-2023. En la segunda fase, se precisaron los elementos necesarios para la elaboración del manual empleando el diseño instruccional modelo ADDIE, y la tercera fase correspondiente a la validación de la propuesta diseñada con expertos. Los resultados obtenidos en este trabajo, permitiron la configuración el recurso digital que servirá como apoyo a los recursos tecnológicos necesarios para tal fin
Impacto de la oficina virtual en la práctica pedagógica en línea del docente universitario
Authors: Rea Greymar
Published: February 2024

La virtualización universitaria trajo consigo mejoras en la calidad de los procesos administrativos y educativos en respuesta a las demandas educativas actuales; bajo esta perspectiva el artículo tuvo como objetivo reportar una investigación cuyo propósito fue el análisis del impacto de la oficina virtual en la práctica pedagógica en línea del docente universitario de postgrado de la Universidad Pedagógica Experimental Libertador – Instituto Pedagógico de Barquisimeto, la misma se desarrolló bajo el paradigma positivista, enfoque cuantitativo, no experimental de tipo descriptivo. Las técnicas utilizadas para recolectar la información fue la encuesta, y el instrumento el cuestionario en escala de Likert. La población de estudio estuvo constituida por 31 docentes de postgrado, y se hizo uso del muestreo intencional, seleccionando a 12 docentes con características específicas. Respecto al análisis de la información, se procesó por medio de estadística descriptiva. Finalmente, los resultados arrojaron que la oficina virtual de la UPEL-IPB es un entorno interactivo en línea por excelencia donde se gestionan procesos administrativos y académicos y que a través de apoyo técnico y asesorías facilita recursos didácticos propios de la plataforma Moodle y la web 2.0 que permite a los docentes universitarios adquirir herramientas para optimizar su práctica pedagógica en línea en las aulas virtuales.
Métodos para la evaluación de la aptitud física en los alumnos con necesidades especiales
Authors: Pita Rodríguez Marcos Rafael
Published: February 2024

La valoración de la aptitud física al inicio del año escolar es fundamental en la clase de educacion física ya que permite al docente conocer las capacidades físicas de sus alumnos y el nivel de carga física aplicable para considerar el logro de los objetivos propuestos en el currículo, ahora bien, cuando un alumno presenta alguna necesidad especial que acción realiza el docente para valorar de forma equitativa y con veracidad a dicho alumnos. ¿Cuáles métodos puede el docente implementar para ser inclusivo y brindar la misma oportunidad a estos alumnos? El objetivo de este estudio fue recopilar diversos métodos de evaluación de aptitud física que puedan ser adaptados para su aplicación en alumnos con necesidades especiales. Se hizo uso del método de estrategia de búsqueda dentro de una revisión documental sistematizada donde el aspecto metodológico esencial fue la extracción de artículos referentes a los distintos métodos de evaluación para la aptitud física, los cuales representan los datos de la investigación. Además de esto se tomó en cuenta para los aspectos metodológicos el uso de filtros por medio del uso de palabras claves tales como; (aptitud física, necesidades especiales, evaluación), de esta forma simplificando el proceso de búsqueda de los datos. En ese mismo orden, se llevó a cabo una evaluación de los resultados obtenidos donde se valoró la relevancia de la información contenida junto con los aspectos claves relacionados con el tema y objetivo de este estudio.
Competencias investigativas desde la gestión docente del psicólogo
Authors: Piñango Mascareño Oscar Gerardo , Montero Sopilca Any Sofia
Published: February 2024

El individuo está en constante búsqueda de conocimiento para dar respuesta a incógnitas y necesidades de la realidad social. En este contexto el docente está llamado a desarrollar habilidades para producir conocimiento, investigar y vincular el ser con el hacer apoyado en competencias investigativas impulsadoras de su actuación. El propósito del estudio fue generar reflexiones en torno a competencias investigativas presentes en la gestión docente del psicólogo. El presente ensayo se sustenta en el análisis a una revisión documental del tema, se reflexionó en torno a cuatro competencias investigativas fundamentales que son la escritural, discursiva, analítica e interpretativa. Así, la gestión docente del psicólogo otorga prioridad a las investigativas que contribuyen en habilidades de pensamiento crítico, responsabilidad social, manejo de tecnologías, creatividad e innovación y afectividad. El Psicólogo en su gestión docente, debe mostrar competencias específicas y transversales inherentes a su profesión enriqueciendo su función como promotor de saberes.
Geoengineering Evaluation of Dammam Formation Rocks-Bahr Al-Najaf Depression-Middle of Iraq
Authors: Al-Amar Haider
Published: February 2024

The Dammam Formation, 250-meter-thick geological formation in the Bahr Al-Najaf Depression that is part of the Salman Platform, comprises re-crystallized limestone mixed with nummulite near the base. It was deposited in a shallow marine environment and extends from Al-Qaim to Samawa along the Euphrates River. The formation is part of the secondary Salman Zone of the main outstanding Stable Shelf. The engineering evaluation of the Dammam Formation in Bahr Al-Najaf depression was determined by ten samples which were chosen to represent the study area. The study includes both field and laboratory components. On the field side, data on the study region and samples were obtained. Physical, engineering, chemical, and mineralogy tests were carried out in laboratories. The total density ranges from 1.848 to 2.664 gm/cm3, the porosity value ranges from 5–20 %, while the water absorption of limestone rocks values 1-7.7 %. Engineering tests were performed, including uniaxial compressive strength, which ranges between 59 and 177 Mpa. The rocks of the Dammam Formation are suitable for the manufacture of Portland cement according to global standards, as supported by chemical analysis.
Calculating the Water Balance for Kubaisa Basin by Simulating the SWAT Model, Western Iraqi Desert
Authors: Al-Kubaisi Mahmood
Published: February 2024

This study aims to calculate the water balance of the Kubaisa Basin in the Western Iraqi Desert using the SWAT model. The study is based on simulating water discharges and the factors affecting them over several years (1990-2023). The geographical, climatic, and hydrological data were collected to run the model. The research results indicate that water distribution in the Kubaisa Basin was estimated during the studied period, including the quantities of surface water, groundwater, and discharges. Climatic results for the Kubaisa Basin indicated an increase in the trend line for total rainfall, temperature, humidity as a relative, and solar radiation, while the trend line retreated for wind speed for the same period. The results of the hydrological components of the basin, which were shown by the SWAT model, namely rainfall (RN-P), surface runoff (SR-Q), flow as lateral (LT-Q), flow as groundwater (GW-F), evapotranspiration as actual (ET), evapotranspiration as potential (PET), water-yield (WLD), and water that permeates past (percolates) the root zone (PEC) which are considered the main elements of the water balance, had values of 79.72mm, 3.10mm, 0.02182mm, 0.0028mm, 76.47mm, 1742.16mm, 3.12mm, and 0.00mm, respectively. This research makes important contributions to the understanding and management of water resources in the Kubaisa Basin and the Western Iraqi Desert regions and can be a basis for future research in the field of improving water sustainability in these regions.
Geomorphology of Pramuka Cay, Kepulauan Seribu Regency, Jakarta, Indonesia
Authors: Cahyadi Ahmad , Marfai Muh , Adji Tjahyo , Riyanto Indra , Wacano Dhandhun
Published: February 2024

Small islands have unique characteristics that make them highly vulnerable to environmental damage and disasters. A good understanding of geomorphological characteristics will greatly assist in understanding the potential damage to natural resources that may occur, as well as help in planning better environmental management and assist in more effective disaster mitigation in the future. This study aims to analyze geomorphological characteristics and identify their influence on potential environmental damage and existing geomorphological hazards. The analysis shows that the geomorphological characteristics of Pramuka Cay cause it to have potential environmental damage and geomorphological hazards consisting of high vulnerability to sea level rise, water resource scarcity, seawater intrusion, groundwater pollution, coastal erosion and tsunami.
Unlocking the Mysteries of the Mishrif Formation: Seismic Data Reinterpretation and Structural Analysis for Reservoir Performance Optimization in the Garraf Oil Field, Southern Iraq
Authors: Al-Rikaby Alaa , Al-Jawad Mohammed
Published: February 2024

The seismic survey is based on the reflected wave’s inherent nature from the interface among layers, which depends on the layer's density and velocity. This is called acoustic impedance and is used to resolve the confusion associated with the stratigraphic structure of the Mishrif formations in the Garraf oil field. The seismic section of the Garraf oil field in Thi-Qar Province, south of Iraq, was analyzed and interpreted. Considering the most important petroleum accumulation reservoir in the Garraf oil field, to update the structural images of the Mishrif Formation. A seismic study of the actual amplitude reflections, temporal maps, and three-dimensional depositional models demonstrated that the Mishrif Formation generate hydrocarbon from an individual structural trap in the presence of oil. Numerous abrupt discontinuities were observed in the seismic reflectors of the reservoir units of the Mishrif Formation, suggesting either a reef or a fault. The correct probability can be shown by establishing a historical match between the reservoir model and the actual behavior of the reservoir or by running a 3D vertical seismic profile log (VSP), which is more precise than the seismic survey previously used to explore faults.
ANALISA PEMBAYARAN INTERNASIONAL MELALUI LETTER OF CREDIT TERHADAP PERDAGANGAN EKSPOR BATUBARA PADA PT. MANDIRI INTIPERKASA
Authors: Azhari Munir , Setyowuni Agnis
Published: February 2024

Analysis of International payments through letter of credit on coal export trade at PT. Mandiri Intiperkasa. Discusses coal export payment procedures using Letters of Credit. The research used is descriptive qualitative research. The data collection techniques used in preparing this thesis were direct observation, interviews and documentation. The results of the research are that international payments use letters of credit in theory in Amir MS's book and in reality in PT. Mandiri Intiperkasa is in compliance. Letters of Credit are safe for both parties. This has been required by the government for coal mining companies to use Letters of Credit in coal commodity export transactions. This is required because it supports the country's foreign exchange. It is hoped that PT. Mandiri Intiperkasa to have books related to international trade, especially coal. To increase information for employees regarding the payment system using a Letter of Credit.
PERANCANGAN MOCK UP SISTEM INFORMASI MANAJEMEN DESA BERBASIS WEBSITE (STUDI DI DESA MEKARMUKTI KECAMATAN CISAGA KABUPATEN CIAMIS JAWA BARAT)
Authors: Pradita Nanang , Huda Miftahul , Hidayat Rahmat
Published: February 2024

Mekarmukti Village is located in Cisaga District, Ciamis Regency, West Java, Indonesia. The village is famous for its natural beauty and cultural heritage, as well as its agricultural practices. The village is surrounded by lush green forests and hills, making it a popular destination for tourists looking to explore the natural beauty of West Java. One issue that often arises in the Mekarmukti Village community that is the focus of attention is the lack of clarity of information conveyed to residents, causing them to repeatedly seek information. The village government has difficulty collecting family data due to various reasons and the busyness faced by residents, hampering the performance of the village government. From the above problems, the purpose of study is designing a Website-based Information System that is used to facilitate the Mekarmukti Village community in getting or obtaining the latest information from the Village Government. In addition to making it easier to get information, this information system also provides information related to tourist info and tourist maps, as well as financial transparency of Mekarmukti Village.
Kajian Yuridis Tanggung Jawab Negara dalam Penerapan Pasal 31 Huruf D Peraturan Daerah No 8 Tahun 2015 Tentang Penyelenggaraan Kesejahteraan Sosial di Kabupaten Jember
Authors: Amalia Lailatul , Fitri Icha Cahyaning
Published: February 2024

: Tujuan dari penelitian berfokus di pengaturan kesehatan pada penerapan Pasal 31 huruf d Peraturan Daerah No. 8 Tahun 2015 Tentang Penyelenggaraan Kesejahteraan Sosial sebagai wujud tanggung jawab negara, khususnya Kabupaten Jember. Adapun metode yang dipergunakan dalam penelitian ini, adalah sebagai berikut. Pendekatan Perundang-Undangan (statute approach). Pendekatan Kon-septual (conseptual approach) Jenis penelitian ini adalah penelitian Yuridis Normatif. bahan hukum primer, sekunder dan tersier. Teknik Analisis Data dengan penelitian hukum kepustakaan. Hasil penelitian ini menunjukkan bahwa diharapkan pihak dari Pemerintahan Kabupaten Jember untuk membentuk Peraturan Daerah (perda) maupun Peraturan Bupati (Perbub) tentang Pelayanan Kesehatan di Kabupaten Jember dengan mencantumkan konsiderans Undang – Undang Nomor 36 Tahun 2009 Tentang Kesehatan. Yang dimana hal tersebut bertujuan untuk menciptakan keharmonisan antara Peraturan Daerah (Perda) atau Peraturan Bupati (Perbub) dengan Peraturan Perundang-Undangan yang terdapat diatasnya. Selain itu juga dapat berfungsi bagi masyarakat di Kabupaten Jember dalam meningkatkan sistem Perekonomian Daerah dari Sektor Pelayanan Kesehatan terhadap masyarakat. Pengharmonisasian terhadap Peraturan Daerah Kabupaten Jember Nomor 8 Tahun 2015 Tentang Penyelenggaraan Kesejahteraan Sosial di Kabupaten Jember dengan Undang-Undang Nomor 36 Tahun 2009 Tentang Pelayanan Kesehatan terdapat ketidaksesuaian. Hal tersebut berupa tidak dican-tumkannya Undang-Undang Nomor 36 Tahun 2009 Tentang Pelayanan Kesehatan dalam konsiderans Peraturan Daerah Kabupaten Jember Nomor 8 Tahun 2015 Tentang Penyelenggaraan Kesejahteraan Sosial yang menyebabkan ketidak harmonisasian pembentukan Perundang-Undangan khususnya dengan Peraturan Undang-Undang diatasnya.
Pemberdayaan Masyarakat Untuk Meningkatkan Kualitas Hidup
Authors: Pradana Dimas Shakti , Damayanti Dita Tristanti , Widyasari Dyah Rahayu , Aryanti Effie Dwi , Aryani Eka Yeni , Terani Eldiana , Yuliana Yomimma Vienna
Published: February 2024

This Thematic Real Work Lecture activity focuses on community empowerment to improve the quality of life for children at the Aisha Jena Orphanage Foundation in the hope of increasing knowledge and improving the quality of life for children. This Thematic Real Work Lecture activity aims to provide socialization and education about mental health and the impact of bullying. Parents certainly have an important role in building children's development, therefore the target in this Thematic Real Work Lecture activity is the creation of success in fostering reasoning power, a sense of responsibility, empathy, and adding direct learning experiences, and applying them in everyday life in society. The method in this Thematic Real Work Lecture activity is in the form of socialization about understanding reasoning power, a sense of responsibility and providing direct education, because not all children in the orphanage know material about mental health and the impact of bullying in order to prevent bullying cases from increasing.
The Process of AI-Aided Drug Design
Authors: Shirolkar Aditya , Kethar Jothsna , Appavu Rajagopal
Published: February 2024

Artificial Intelligence (AI) is a growing field in today’s world and plays a part in many industries today. Its role in drug design and the biological sciences has begun to expand in recent years. DeepChem is an open source tool that explores and employs the methods behind drug design. The tool’s process and end result will be indicative of how well AI can perform the job of drug discovery and how much it can expedite the process, as well as reveal the future of tools like DeepChem. DeepChem handles everything from data processing to fitting AI models to performing predictions on proposed molecules. By applying DeepChem and reviewing it, we will be revealing AI’s power and limitations in biomedical chemistry and technology. In addition, other AI tools, such as Chemistry 42 and inClinico by Insilico that achieve other parts of the drug design process. Completing a comprehensive review of these methods will provide an overview of what can be improved and the scope of AI as a big money-maker and solution in the biomedical field. The synthesis of drugs is a complicated process that can be simplified by AI tools. This paper explores how AI tools operate and their limitations in the medicinal world.