bluuebunny/crossref_metadata_2025 huggingface dataset:
Biomass study of Anabaena sphaerica cultivated in electroplating industrial effluent
Authors: Yasodha. T Dr. , A Sugapriya , S Reethika , Hepsiba A Christy , M Abi , M Ishwarya
Published: March 2024

The growth of microalga Anabaena sphaerica in electroplating industrial effluent with reference to the vegetative cells , heterocysts and dry biomass weight brings about oxygenation and mineralization in addition to the increase in biomass which serve as a multipurpose raw material to the industries. From lab scale experiments it is demonstrated that the present investigation could be converted to pilot study for large scale production of biofuel and other commodity chemicals. Cultivation of microalgal biomass as a potential resource / raw material for various industries to produce commodity chemicals could enhance the economy and curtail the environmental hazards.
Study of the binding of copper (II) ions to the heavy chain of silk fibroin using the charmm22 force field
Authors: Polvonova Gulinur , Eshchanov Khushnudbek , Esomurodova Risolat
Published: March 2024

Silk fibroin is of great interest due to its unique mechanical properties and preparation of biomaterials. It is important to study the mechanisms of the interaction of fibroin with metal ions and the composition of the resulting complexes. We studied the possibilities of coordination binding of copper (II) ions to the heavy chain of the silk fibroin molecule of calculations using the CHARMM22 force field and determined the optimal parts for coordination bonds. To practically confirm the results obtained in theoretical calculations, samples of fibroin containing copper (II) ions were analyzed by ATR-FTIR spectroscopy, and it was proved that copper ions are coordinately bound to the groups in fibroin. The agreement of the results obtained in the theoretical calculations with the results of the actual analysis confirms that indeed, copper (II) ions correspond to the conditions studied by modelling.
Tuberous Sclerosis or Bourneville-pringle disease: A rare case report
Authors: Kumar Veshar Harsh , Veer Bahadur Singh  , Mayank Shrivastava  , Ibrahim Khan  , Kapil Singh Meena  , Sourabh Soni  , Amit Kant  , Singh Saranshi
Published: March 2024

Introduction: Tuberous sclerosis or Bourneville’s disease is rare autosomal dominant neurocutaneous. Which is characterized by Skin changes, neurological issues, and the development of hamartomas in several organs that cause morbidity and mortality. The gingival hyperplasia, fibromas, hypopigmented lesion’s and enamel hypoplasia are the most typical features of presentation. The case report emphasises on the crucial clinical characteristics, radiographic characteristics, and laboratory abnormalities of Tuberous Sclerosis assisting in the early detection and treatment of such a rare illness.
Case presentation: In this report, we present a case of tuberous sclerosis in a 25-year- old female who displayed abnormal body movement along with a hypopigmented macule, ash leaf spots, periungual fibroma, gum hyperplasia, and hematuria with pain in the bilateral flank.
Conclusion: Our aim is to raise awareness for tuberous sclerosis by using this instance to highlight the disease's rarity and the difficulty in identifying and treating cases like this.
Billing and online payment portal with multi-factor authentication using one-time password
Authors: Mae Reyes Aribon-Libag Christle
Published: March 2024

NCTVN Cable Network Corporation is a cable/internet distributor in Kidapawan City. Its area of operation covers Makilala, Arakan, Antipas,Matalam, Midsayap,Magpet President Roxas, Kabacan and Kidapawan City. The users of cable and internet rely to them in which they have to extend their services to the Province. By this venture, the number of subscribers of their services has grown and the area covered are widen. Given the number of subscribers there is a need to create a consistent and quick support to their customers in terms of billing presentment and payment. In the current process, Billing and delivery of the statement is one of the challenges they are facing where they usually cover cost for their workforce, paying onsite over the counter of the subscribers takes a lot of time and payment is unsafe if the collector will intend to run the money. NCTVN manual process cannot take it enough to manage their business. The aim of this project is to help the NCTVN Cable Network Corporation by developing billing and online payment portal integrated with multi-factor authentication. There are two way to access the site. First, Web Portal and Second, Mobile Application named NPAy Application (app). The system enables the customer to pay their monthly bill through the use of online payment portal using available merchants like Gcash, Maya, coin.ph and many other as payment gateway with added security features to secure the customer’s information and payment online.
The best part of this app is the easiness of the users (referring to admin and customer) to access their NPay app anytime and anywhere as long as the customer is connected with internet, see their monthly bills, pay online and secure the system process and transaction from registration of customer’s account down to the payment process where system will validate or authenticate using One-Time Password (OTP).
The App is design to serve one user’s roles: The Subscribers of NCTVN Cable Network Corporation. For the designing and development of the project, PHP has been used for the programming language and MySQL for the integration of database, and this system was hosted in exonhost.com with the live domain name of www.nctvn2022.site as official address. Varieties of methods of testing were applied to test if the anticipated output was effectively delivered. Test results and cases were created and distributed. The outcomes show that the system satisfied the user's expectations and successfully completed the testing phase.
Furthermore, this system is optional for the users due to the following factors: First, Subscribers are from far flung barangay with no internet or cellular connection, and no mobile phones or Personal Computer. But for the customers who intend to use it. This system is beneficial to them because the process and customer will experience direct support from the company with the contact less setup, fast, easy-to-used and effective billing and payment portal with security features.
Quantification of bioactive constituents of mistletoe leaves (tapinanthus globiferus a. rich) from four different host plants in the EWU community
Authors: A. Owolabi Tunde , O Edobor Salome
Published: March 2024

Background: Pharmacological activities of the medicinal plant are determined by the chemical substances it contains, these substances are also affected by factors of which geographical and all that surround such plant plays a vital role. Mistletoe is a plant that depends solely on its host. This study evaluated the different phytoconstituents concentrations in Mistletoe (Tapinanthus globiferus) leaves growing on four different host plants (Avocado pear (Persea americana), Orange (Citrus sinensis), Guava (Psidium guajava), and Kolanut (Cola nitida)) in the Ewu community of Edo State, Nigeria.Methods: Qualitative and quantitative phytochemical analyses were carried out using standard methods.Results: The qualitative test revealed the presence of alkaloids, Tannin, Phenolic compounds, Flavonoid, Saponin, while the quantification estimation showed these phytochemicals in varying concentrations. Guava had the highest concentration of Tannin (323.4Â±0.07), Saponin (138.6 Â± 0.02) while Orange has the highest concentration of Flavonoids (632.61 Â± 0.12) followed by Guava (407.88 Â± 0.05), the highest concentration of Phenolics was found in Avocado pear (519.9 Â± 0.29) followed by Guava (273.5 Â± 0.34). The highest Alkaloids were found in Orange (2.20 Â± 0.06) followed by Avocado pear respectively.Conclusion: From this present study, it can be concluded that Mistletoe from different host plants has a different concentration of phytochemicals and is thus expected to have different bioactivities.Â Â
Evolution of the aggressive or scaling character of the water according to the dose of corrosion inhibitor
Authors: Mbayo Kyongo Longo Jerry , Mbuyu Ilunga Eddy , Wa Banza Bonaventure Banza , Kanda Jean-Marie
Published: March 2024

In the treatment of water to fight against corrosion, there are several techniques that can slow down this phenomenon and thus extend the service life of the pipes. Among these techniques, the use of corrosion inhibitors is one of them. It is in this context that the evolution of the aggressive and turbulent nature of the water of the Lubumbashi River has been studied experimentally through the determination of indicators such as pH, chemical potential, total alkalimetric titre, calcium hardness THCa, free chlorine content, dissolved oxygen content, SO42- sulfate ion content and Ryznard and Langelier index. Numerous relationships between the dose of the inhibitor and the physicochemical parameters of water have been established. Similarly, it has also been shown that the dose variation of the inhibitor is related to the Langelier index and the Ryznard index. Thus, it follows that with the dose of 0.30ml / L, an appreciable decrease in dissolved oxygen, which is the main oxidant in basic medium, is recorded. The use of the inhibitor has a positive effect on corrosion because it acts directly on all physicochemical parameters and on all oxidants. Subject to economic analyzes, the dose of 0.30 ml / L is more advisable especially as it would prevent in the cooling circuit degradation of the thermal coefficient and the formation of precipitates in the exchangers occasioned.Â Â
Alphaâ€“conotoxin, omegaâ€“conotoxin and muâ€“conotoxin timeâ€“resolved absorption and resonance FTâ€“IR and Raman biospectroscopy and density functional theory (DFT) investigation of vibronicâ€“mode coupling structure in vibrational spectra analysis
Authors: Heidari Alireza , Esposito Jennifer , Caissutti Angela
Published: March 2024

A Conotoxin is one of a group of neurotoxic peptides isolated from the venom of the marine cone snail, genus Conus. Conotoxins, which are peptides consisting of 10 to 30 amino acid residues, typically have one or more disulfide bonds. Conotoxins have a variety of mechanisms of actions, most of which have not been determined. However, it appears that many of these peptides modulate the activity of ion channels. Over the last few decades Conotoxins have been the subject of pharmacological interest. Parameters such as FTÂ­â€“IR and Raman vibrational wavelengths and intensities for single crystal Alphaâ€“Conotoxin, Omegaâ€“Conotoxin and Muâ€“Conotoxin are calculated using density functional theory and were compared with empirical results. The investigation about vibrational spectrum of cycle dimers in crystal with carboxyl groups from each molecule of acid was shown that it leads to create Hydrogen bounds for adjacent molecules. The current study aimed to investigate the possibility of simulating the empirical values. Analysis of vibrational spectrum of Alphaâ€“Conotoxin, Omegaâ€“Conotoxin and Muâ€“Conotoxin is performed based on theoretical simulation and FTâ€“IR empirical spectrum and Raman empirical spectrum using density functional theory in levels of F/6â€“31G*, HF/6â€“31++G**, MP2/6â€“31G, MP2/6â€“31++G**, BLYP/6â€“31G, BLYP/6â€“31++G**, B3LYP/6â€“31G and B3LYP6â€“31â€“HEG**. Vibration modes of methylene, carboxyl acid and phenyl cycle are separately investigated. The obtained values confirm high accuracy and validity of results obtained from calculations.Â
Antimicrobial activities of Desi Cow Dung Extracts against human pathogens and phytochemical analysis using chloroform extracts
Authors: Nayak Arabinda , Gohel Shivani
Published: March 2024

The main objective is to examine the anti-microbial properties and Photochemical screening of the cow dung extracts which are useful to kill the pathogens in humans.Nowadays there is increasing microbial drug resistance problem, so new alternative to synthetics drugs are explored. Along with it antimicrobial activities of natural products are in search. Study of anti-microbial activities of desi cow dung extracts of chloroform against microorganisms namely E. coli and K. Pneumonia.Also the phytochemical analysis for the flavonoids, glycosides, steroids, tannins and phenol compounds. The antimicrobial sensitivity test by disk diffusion method and the disk made from the cow dung showed the zone of inhibition in the petri-plates of both the microorganisms namely E. coli and K. Pneumonia.The phytochemical analysis also showed colour change and precipitation except the phenols. As the microorganisms are becoming resistant to the antibiotics and synthetic drugs, new alternate natural drugs can be explored and used against several diseases caused by this microorganisms.Â Â
A narrative review on the effectiveness of therapeutic communication in reducing anxiety in children during dental treatment procedures
Authors: Ridho Fiki Muhammad , Fauzan Moh.
Published: March 2024

Background: Dental anxiety is anxiety about dental treatment carried out before or immediately after a dental treatment procedure, which will have an impact on the difficulty of the dental team in carrying out dental treatment. One of the interventions that the dental team can carry out with pediatric patients is therapeutic communication.
Objective: This study aims to further discuss regarding the effectiveness of therapeutic communication in reducing anxiety in children during dental treatment procedures.
Methods: A systematic search of the Google Scholar database, then a narrative review of the identified articles was conducted with a focus on articles published in the last 10 years.
Discussion: Therapeutic communication, a non-pharmacological intervention, plays an important role in managing anxiety in children when undergoing dental treatment procedures, because it has the benefit of reducing psychological problems in children such as anxiety, fear and changes in behavior, especially during dental treatment procedures. Some scientific evidence shows a significant value of p <0.05 and an OR value >1 which indicates a correlation between therapeutic communication and the level of dental anxiety.
Conclusion: Based on the results of the narrative review conducted, we conclude that the better the therapeutic communication carried out by the dental team, the lower the level of anxiety in children during dental treatment procedures.
Uncaria-derived alkaloids: A review on the mechanism in inducing apoptosis in oral squamous cell carcinoma
Authors: Ridho Fiki Muhammad , Ulfah Kamailiya , Aruan Iren Angelia , Pramaztri Naurah Nabilah , Laksono Eko Puji , Putri Aurellia Nuraini Anindito
Published: March 2024

Alkaloids, the major secondary metabolite compounds identified in the genus Uncaria, exhibit the ability to induce apoptosis in oral squa-mous cell carcinoma (OSCC). Various potential alkaloids in herbal medicine have been explored and provided promising results, one of which is the potential to induce apoptosis. This study aims to provide a more comprehensive review of the mechanism of alkaloids derived from Uncaria in inducing apoptosis in OSCC. In the systematic search conducted, the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were adhered to conduct this review through the databases, including PubMed, ScienceDirect, Wiley and a manual search using Google Scholar. According to the findings, this review states that several types of alkaloids derived from Uncaria that have been reviewed, such as hirsutine, rhynchophylline, isorhynchophylline, and hirsuteine, have different mechanisms in in-ducing apoptosis in OSCC, both through intrinsic and extrinsic pathways. The evidence presented in the present study provides an oppor-tunity for future research to determine the appropriate therapeutic dose based on the specific alkaloid, duration of therapeutic administration, and in vivo and/or in human testing.
Osteomielite como complicação de trauma de face em paciente descompensado sistemicamente
Authors: Soares Júlia Mendonça , Pinto Karoline Von Ahn , Borges Hedelson Odenir Iecher , Stabile Glaykon Alex Vitti
Published: March 2024

Introdução: A osteomielite é uma inflamação do osso medular, geralmente na mandíbula. Objetivo: O objetivo desse artigo é relatar um caso de osteomielite supurativa crônica desenvolvida a partir de um trauma de mandíbula não tratado em paciente portador de diabetes mellitus tipo 2 e hipertensão descompensadas. Relato do caso: Um paciente do sexo masculino, 56 anos de idade, compareceu ao pronto-socorro queixando-se de dor na face e inchaço há dez dias. Na anamnese, relatou ter diabetes mellitus tipo 2, hipertensão, etilismo crônico, tabagismo, e ter sofrido um acidente vascular cerebral há três meses. No exame extrabucal, observou-se inchaço no terço inferior da face no lado esquerdo, na região do corpo e ângulo mandibular, com perda de continuidade e dor. No exame intrabucal, verificou-se fratura do dente #38, com secreção purulenta e tumefação dos tecidos. Os exames de imagem indicaram fratura mandibular e presença de sequestros ósseos. Optou-se por cirurgia sob anestesia geral, com remoção do sequestro ósseo e fixação interna rígida, resultando na regressão dos sintomas e controle do quadro sistêmico. Considerações finais: Fatores como resistência do hospedeiro, doenças sistêmicas, etilismo e tabagismo tornam desafiador o controle e o tratamento da osteomielite. Dessa forma, uma atuação multidisciplinar é necessária para a remoção do foco infeccioso e o controle da situação sistêmica.
Uma entrevista com Leandro Saad
Authors: Saad Leandro
Published: March 2024

O Colégio Brasileiro de Cirurgia e Traumatologia Buco-Maxilo-Facial entrevista, nesta edição da Revista, Leandro Saad, advogado do CBCTBMF e Professor titular de Direito Processual Civil da ESAMC – Escola Superior de Administração Marketing e Comunicação (Santos/SP, Brasil).
Avaliação do conhecimento dos alunos de graduação sobre a especialidade/residência em Cirurgia e Traumatologia Buco-Maxilo-Facial
Authors: Calado Thiago Hungria de Souza , Januário Douglas do Nascimento , Silva Matheus Menezes da , Moraes Sylvio Luiz Costa de , Silva Jonathan Ribeiro da
Published: March 2024

Objetivo: O presente estudo objetivou avaliar o conhecimento de alunos do último ano do curso de graduação em Odontologia, do Centro Universitário São José (Rio de Janeiro/RJ) e do Centro Universitário Serra dos Órgãos (Teresópolis/RJ), em relação aos programas de residência e especialização em Cirurgia e Traumatologia Buco-Maxilo-Facial no estado do Rio de Janeiro. Métodos: A coleta de dados, de um total de 89 estudantes, foi realizada por meio de um questionário padronizado, com posterior análise estatística descritiva. Foram formuladas perguntas acerca dos seguintes âmbitos: administrativo, trabalhista e técnico-científico — além de perguntas diversas sobre a especialidade. Conclusão: Pode-se concluir que uma parcela significativa dos estudantes não possui o conhecimento adequado quanto aos programas de residência e devem ser conscientizados sobre a importância desse tema.
Internação hospitalar de pacientes com infecção odontogênica
Authors: Bezerra Kelly Tambasco , Abreu Gabriela Laterça da Silva , Sturzinger George Patrick Sotero , Santos Roberto Gomes dos , Rodriguez Jose Luiz Gonzalez , Lima Glauco Siqueira , Miranda Águida Maria Menezes Aguiar
Published: March 2024

Introdução: A infecção odontogênica origina-se dos tecidos dentários e periodontais, podendo manifestar-se como processos localizados ou disseminar-se para espaços fasciais profundos, alcançando estruturas anatômicas críticas. Representa um risco significativo para os pacientes, devido à possibilidade de complicações potencialmente graves e até mesmo óbito. Objetivo: Realizar uma revisão atualizada da literatura e elaborar uma proposta de protocolo com parâmetros para orientação de profissionais quanto à admissão e alta hospitalar de casos com infecção odontogênica. Resultados: Pacientes que apresentam sinais de gravidade, especialmente dispneia, disfagia, trismo severo, edema e/ou eritema em regiões cervical e torácica, devem ser internados, pois esses parâmetros indicam disseminação da infecção para espaços profundos e comprometimento das vias aéreas. Conclusões: A criação de protocolos é fundamental para garantir o manejo adequado dos pacientes, reduzir os custos para os sistemas de saúde e padronizar as condutas profissionais.
O que os estudantes de Odontologia sabem sobre a osteonecrose dos maxilares relacionada a medicamentos: um estudo multicêntrico em cinco universidades brasileiras
Authors: Silva Jonathan Ribeiro da , Moraes Sylvio Luiz Costa de , Pereira Rodrigo , Vieira Eduardo Hochuli , Moreira Júlia Morais , Tavares Junior Hélio Huguenin
Published: March 2024

Objetivo: O objetivo do presente estudo multicêntrico foi avaliar o conhecimento de estudantes de Odontologia sobre a osteonecrose dos maxilares relacionada a medicamentos (MRONJ), em cinco universidades brasileiras. Metodologia: Cento e oitenta e três estudantes de cinco universidades brasileiras do Rio de Janeiro, São Paulo e Santa Catarina responderam a um questionário com seis questões sobre MRONJ, sem limite de tempo e sem acesso a bibliografia ou outras fontes de informações. As variáveis foram analisadas pelo teste exato de Fisher e teste Qui-quadrado. Um nível de significância de 5% foi utilizado para todos os testes. Resultados: Nas respostas às entrevistas, 75,41% dos alunos afirmaram saber o que são bifosfonatos e 18,03% relataram o tratamento de algum paciente em uso desse medicamento durante o curso de Odontologia. Entretanto, apenas 7,10% relataram o atendimento odontológico de pacientes com lesões intrabucais. Não houve correlação estatisticamente significativa entre os estudantes que informaram saber o que são bifosfonatos e suas respostas sobre a realização de procedimentos odontológicos em pacientes em uso desses medicamentos. Apesar disso, foi possível observar que todos os alunos que atenderam pacientes com lesões relacionadas à osteonecrose foram mais cautelosos em propor procedimentos nesses pacientes. Conclusão: Os resultados demonstraram que os alunos possuem conhecimento sobre a patologia e os bifosfonatos; porém, esse é superficial e insuficiente para um possível tratamento desses pacientes.
Excisão cirúrgica de adenoma pleomórfico: relato de caso
Authors: Costa Eduardo Dias , Silva Maria Eduarda Noberto de Morais , Brandão Samyra Nathália Gomes , Souza Wallison Melo Ferreira de , Martorelli Fernando de Oliveira
Published: March 2024

Introdução: A forma de tratamento definitiva do adenoma pleomórfico (AP), neoplasia benigna mais comum das glândulas salivares menores, é a excisão cirúrgica completa. Objetivo: O objetivo deste artigo é relatar um caso clínico de AP localizado na região de palato duro, tratado por excisão cirúrgica completa. Relato de caso: Paciente do sexo masculino, 58 anos de idade, encaminhado para avaliação clínica com queixa de “um caroço no céu da boca”, com evolução há mais de cinco anos. Ao exame intrabucal, observou-se um aumento de volume no palato duro. Com base nas características clínicas da lesão, o tratamento foi a excisão seguida de exame histopatológico, o qual confirmou o AP. No pós-operatório, foi utilizada uma placa confeccionada em resina, para melhor conforto ao paciente, que se encontra em acompanhamento e sem sinais de recidiva da lesão ou queixas locais. Discussão: O AP apresenta crescimento lento e, quando negligenciado, pode atingir grandes dimensões, aumentando a morbidade do procedimento cirúrgico. Seu diagnóstico é clínico, e a confirmação é feita a partir de exame anatomopatológico. Conclusão: É importante enfatizar a importância de o cirurgião-dentista estar atento a alterações que possam surgir na cavidade bucal, visando um diagnóstico precoce. Salienta-se, ainda, que, quando viável, dispositivos intrabucais devem ser utilizados para trazer conforto ao paciente no pós-operatório.
Apigenin 7-glucoside impedes hypoxia-induced malignant phenotypes of cervical cancer cells in a p16-dependent manner
Authors: Li Yan , Man Xiaoli , Zhang Qing , Wang Xiaowu , Yang Yongli
Published: March 2024

Apigenin 7-glucoside (A7G) can suppress cell proliferation and trigger apoptosis in cervical cancer cells. Considering that hypoxia is associated with the malignant phenotypes in cervical cancer, this study aimed to uncover whether A7G exhibits suppressive effects on the hypoxia-induced malignant phenotype of cervical cancer cells (HeLa cells). Compared to normoxia, hypoxia can enhance the malignant phenotypes of HeLa cells, including cell proliferation, reduced sensitivity against chemotherapeutic agents (oxaliplatin and paclitaxel), cancer stemness, migration, and invasion. A7G intervention (20, 40, and 60 μM) could impair these malignant phenotypes of HeLa cells and upregulate the expression level of total and nuclear p16 proteins. Molecular docking analysis showed the interaction between anion exchanger 1 and A7G. In p16-silencing HeLa cells, the anticancer effects of A7G were absent. Therefore, hypoxia derives malignant phenotypes of HeLa cells, which could be impeded by A7G in a p16-dependent manner.
Assessment of indirect tensile stress and tensile–strength ratio and creep compliance in HMA mixes with micro-silica and PMB
Authors: Al-ghurabi Sahar Basim , Al-gurah Esraa R. , Mohammed Hamza Walaa
Published: March 2024

This study aims to ascertain the effects of polymer-modified bitumen (PMB) and to utilize mineral filler with micro-silica (MS) on various properties of hot-mix asphalt (HMA). In this work, three specimens of an asphalt-concrete mixture were prepared. The first specimen represents a control mixture, the second specimen contains MS at rates 15, 30, and 45% by the total weight of the total aggregate as filler, and the third specimen contains MS and PMB with 4% novolac by the weight of bitumen and 15% hexamine by the weight of the novolac. The properties of designed mixes were evaluated using the indirect tensile strength test, tensile–strength ratio, and creep compliance. The test results showed an increase in the resistance of asphalt concrete to moisture damage, a reduction influence of water on asphalt concrete properties, creep compliance values indicating growing stiffness for asphalt mixture, and enhanced fatigue life. In conclusion, using 45% MS and PMB improved the properties of HMA and provided long-lasting mixtures for highway construction.
Comparative analysis of flow factors and crystallinity in conventional extrusion and gas-assisted extrusion
Authors: Huang Xuemei , Liu Hesheng , Huang Xingyuan , Huang Yibin , Yu Zhong
Published: March 2024

Two-dimensional models of die-melt and die-gas-melt were created using Polyflow software. The radial and axial directions flow rate, shear rate, pressure, and first normal stress of the specimen were numerically simulated under conventional extrusion and gas-assisted extrusion while taking into consideration the heat transfer on the free surface of the specimen. The crystallinity was determined by combining the simulation data with the crystallization kinetics equation. The computation results are then examined using Origin software. The findings demonstrate that the use of gas-assisted extrusion technology can cause the Vx
to decrease or even turn negative by reducing the friction between the melting edge and the die wall. Additionally, it makes Vy
, pressure, shear rate, temperature, first normal stress, and crystallinity increasingly steady and aids in reducing or avoiding the Barus effect. The crystallization phenomena can be measured by using the crystallization kinetics equation. The study of extruded parts at the microscopic level will benefit from this application.
Twist-related parametric optimization of Joule heating-triggered highly stretchable thermochromic wrapped yarns using technique for order preference by similarity to ideal solution
Authors: Wang Yong , Yuan Zihan , Qi Mingkun , Zhang Lizheng , Li Mingwei , Wang Wei , Li Changlong
Published: March 2024

A scalable approach for manufacturing highly stretchable thermochromic wrapped yarns has been reported previously. Herein, the effects of twist-related technological parameters, namely, wrapping density and outer-inner twist ratio are investigated and have been optimized by technique for order preference by similarity to ideal solution (TOPSIS). The results indicate that the preparatory twist-related parameters have a remarkable effect on the spiral geometrical configuration of yarn constituents, and thus in turn influencing the final tensile and elastic properties of wrapped yarns. The wrapping density of 800 T·m−1 and outer-inner twist ratio of 1.25 were considered as the optimal alternative using TOPSIS. Moreover, a negative relation between voltage and color-changing time of yarn spun with optimal parameters was established. It was also found that the color of yarn above elevated triggered voltages always switched from purple to pink but followed different color-changing paths. More importantly, thermochromic response of yarn is insensitive to the applied strain.
Efficacy of etonogestrel subcutaneous implants versus the levonorgestrel-releasing intrauterine system in the conservative treatment of adenomyosis
Authors: Wei Anwen , Tang Xuedong , Yang Wenjuan , Zhou Jianqing , Zhu Weili , Pan Shan
Published: March 2024

To evaluate the clinical efficacy of etonogestrel subcutaneous implant (ENG-SCI) with that of the levonorgestrel-releasing intrauterine system (LNG-IUD) for adenomyosis treatment. A prospective randomized cohort study was conducted including 108 patients (50 patients in ENG-SCI group and 58 in the LNG-IUD group) with adenomyosis from January 2019 to July 2021. After 3 months of treatment, both ENG-SCI group and LNG-IUD group showed significant improvement in patients’ visual analog scale, pictorial blood loss assessment chart (PBAC), and uterine volume (P ＜ 0.05). The uterine volume of patients in LNG-IUD group decreased more significantly than that in the ENG-SCI group since 3 months of treatment. The PBAC score in the LNG-IUD group improved better than that in the ENG-SCI group since 6 months of treatment (P ＜ 0.05). No significant difference in the occurrence rate of ideal vaginal bleeding patterns and the hemoglobin levels between the two groups was observed. The ENG-SCI group had a higher probability of weight gain and progesterone-related side effects (P ＜ 0.05). Both ENG-SCI and LNG-IUD were effective in treatment of adenomyosis. However, LNG-IUD had a more significant effect in treating adenomyosis-related dysmenorrhea, excessive menstrual flow, anemia, and uterine enlargement, with relatively fewer side effects.
Quantitative methods in the analysis of clozapine in human matrices – A scoping review
Authors: Lim Jia Le , Rajagopal Mogana , Akowuah Gabriel Akyirem , Keshavarzi Fazlollah , Alakhali Khaled Mohammed Ahmed
Published: March 2024

Clozapine (CLZ) has retained its clinical utility in the management of schizophrenia despite the discovery of novel antipsychotics, as it possesses unique efficacy in the setting of treatment resistant schizophrenia while causing minimal extrapyramidal symptoms. However, these benefits are offset by the risk of agranulocytosis and other side effects, and therapeutic drug monitoring (TDM) is routinely recommended for patients undergoing treatment with CLZ. A multitude of approaches for the quantification of CLZ have been developed for different settings such as TDM, quality control of pharmaceutical dosage forms, and toxicology studies. Primarily, these approaches fall under one of three branches of analysis, namely, chromatography, electrochemical analysis, and spectrophotometry. This study provides a scoping review of the recent advances in the methods of quantification for CLZ and highlights the potential utility of novel methods in the field of drug quantification.
A feminizmus élménye
Authors: Hegedüs Ferenc
Published: March 2024

„A »feminizmus élménye« – melynek célzott közönsége a lehető legtöbb individuum – nem politikai álláspont. A patriarchátust könnyebb megfoghatatlan ellenségként kijelölni és monológban felszólalni ellene, mint felhívni a figyelmet egy azzal kéz a kézben járó, szintén hierarchikus gazdasági és társadalmi rendszerre – főként, ha azt a rendszert az adott produktum éppen kiszolgálja.”

Hegedüs Ferenc kritikája a Barbie című filmről.
Újévi jegyzet a szubjektív hatalomról és a laposságról
Authors: Borbély András
Published: March 2024

„Mi lenne, ha a szubjektív társadalmi állapotot úgy fognánk fel, amelyben a kapcsolataink belső formájának kell meghatároznia a társadalmi viszonyokat?“
Ki képviseli a magyar diákokat Kolozsváron?
Authors: Ábrahám Andrea-Tekla , Ilyés Andrea
Published: March 2024

A Kolozsvári Magyar Diákszövetség több mint 30 éve működik, és az egyik legismertebb magyar diákszervezet Erdélyben. De vajon a szervezet valóban a diákokat szolgálja, vagy más érdekek irányítják?
Specifics of Emotional Intelligence in Children of Primary School Age with Partial Immaturity of Higher Mental Functions
Authors:   Novosibirsk State Pedagogical University, Ignatovskaya Elizaveta V.
Published: March 2024

The article presents a theoretical analysis of the problems of development of emotional intelligence in children of primary school age with partial immaturity of higher medical functions. In the reviewed studies, emotional intelligence is defined as a person's ability to navigate the emotional sphere. The work reveals the innovativeness of emotional intelligence for personality development. A comparative analysis of the specifics of emotional intelligence of junior schoolchildren with normotypical development and junior schoolchildren with partial immaturity of higher medical functions is presented. In conclusion, further study of these issues is necessary.
Modul Etnokimia Terintegrasi Nilai Islami pada Pembelajaran Berbasis Proyek untuk Melatih Kreativitas
Authors: Asna Ainuz Zahroh , Sumarni Woro , Cahyono Edy
Published: March 2024

Penelitian ini bertujuan mengembangkan modul Etnokimia Terintegrasi Nilai Islami Pada Pembelajaran Berbasis Proyek Untuk Melatih Kreativitas. Pengembangan modul ini didasari pada fakta bahwa belum banyak modul pembelajaran kimia yang dapat memfasilitasi penerapan kurikulum merdeka sekaligus dapat menguatkan nilai-nilai Islami, terutama untuk sekolah di bawah naungan kementerian agama. Penelitian ini mengambil fokus materi kimia hijau dan struktur atom, dan dikaitkan dengan budaya-budaya di daerah Pati, Jawa Tengah. Selain itu, materi di dalam modul juga dihubungkan dengan nilai-nilai Islami sehingga siswa Madrasah Aliyah (MA) menjadi lebih tertarik untuk mempelajari kimia. Hasil validitas modul oleh ahli media memberikan simpulan sangat valid, artinya modul layak diterapkan dalam pembelajaran. Hasil ujicoba skala kecil juga menunjukan bahwa modul etnikimia terintegrasi nilai Islami pada penelitian ini dapat melatih dan meningkatkan kretivitas siswa dalam belajar.
Upaya Peningkatan Pengetahuan serta Sikap Siswa melalui Pengembangan LKPD PBL Terintegrasi Literasi Lingkungan
Authors: Herawati Meilinda , Nuswowati Murbangun , Susilaningsih Endang , Nurhayati Sri
Published: March 2024

Pandemi covid-19 telah membawa perubahan terutama dalam segi pendidikan sehingga diperlukan pembelajaran dengan media yang menarik dalam upaya peningkatan pengetahuan peserta didik. Media yang dapat dipakai adalah LKPD. Penelitian kali ini bertujuan mendesain LKPD dengan model pembelajaran berbasis masalah terintegrasi literasi lingkungan untuk meningkatkan pengetahuan pada materi hidrolisis garam. Metode yang dipakai dalam penelitian ini berupa RD dengan model 4D, Define, Design, Development, dan Disseminate. Subjek penelitian merupakan 33 siswa SMA N 3 Salatiga. Instrumen yang digunakan berupa lembar validasi LKPD, soal pretest posttest dengan soal pilihan ganda berjumlah 20 soal, angket respon peserta didik, dan angket sikap. Teknik analisis data yang digunakan terdiri atas analisis kelayakan melalui hasil validasi dan respon kepraktisan, analisis keefektifan produk melalui uji N-gain, ketuntasan hasil belajar, dan ketercapaian sikap, serta keterkaitan antara LKPD dengan pengetahuan dan sikap melalui uji product moment menggunakan SPSS.  Berdasarkan hasil penelitian dinyatakan LKPD yang telah didesain memenuhi beberapa kriteria (1) LKPD sangat valid dengan skor dari validator ahli masing-masing 114/116 dan 112/116 dan praktis terlihat melalui hasil angket respon peserta didik sebesar 91%, (2) efektif dalam meningkatkan pengetahuan dengan nilai N-gain 0,62 pada kategori sedang, ketuntasan belajar siswa 100% dan sikap kepedulian peserta didik terhadap lingkungan sebesar 91,35% pada kategori sangat peduli. Keterkaitan LKPD dengan pengetahuan dalam kategori kuat dengan perolehan pearson correlation 0,787, sedangkan keterkaitan LKPD dengan sikap pada kategori lemah dengan perolehan 0,372. Sehingga dapat dikatakan Lembar Kerja Peserta Didik model Problem Based Learning terintegrasi literasi lingkungan layak dan efektif digunakan dalam pembelajarn hidrolisis garam.
The Development of Evaluation Tools to Measure Students' Science Literacy on the Solar System Theme
Authors: Asy'syakurni Nurul Afdhilla , Rusilowati Ani , Sudarmin Sudarmin
Published: March 2024

Nowadays scientific literacy is a concern in the world of education. Various efforts have been made by the Government to improve students' scientific literacy. Efforts are made by changing the current curriculum. However, this has not been followed by the availability of assessment instruments or evaluation tools used to measure students' scientific literacy. The results of observations carried out show that currently the evaluation tool used is only to measure students’ knowledge. This study aims to develop an evaluation tool based on aspects of scientific literacy competence on the theme of the solar system. This study also aims to determine the scientific literacy profile of students through Item Response Theory (IRT) analysis. The research was conducted with a sample of 256 students of class VIII SMP Negeri 2 Salatiga. IRT analysis using the BILOG MG computer program with a 2-parameter logistic model (2-PL). The results of the item analysis showed that of the 30 items, there was one item (item 25) that had a minus biserial correlation value, so item 25 that no calculations for the next phase. From the analysis of the difficulty level index, 86% of the items have a good difficulty index and all items have a good differentiation of problem index. The results of the students' abilities showed that the average obtained was -0.0143. The mean ability with a minus value indicates that most of the students have low abilities.
Development of Observation-Based Hybrid Learning Modules as Learning Media for Biodiversity Materials
Authors: Nafi'ah Miftahun , Ngabekti Sri , Widiatningrum Talitha
Published: March 2024

This study aims to develop an observation-based hybrid learning module as a learning media for biodiversity material. This study uses research and development methods. This research was conducted at MA Darul Ulum Purwogondo Jepara. The subjects of this study consisted of a small-scale trial subject with 20 students and a large-scale trial subject with 68 students. Instruments and data collection techniques in the form of questionnaires and tests of students' cognitive learning outcomes obtained from the pretest and posttest scores. The results showed that (1) the observation-based hybrid learning module was declared valid by validators of media experts and material experts with an average score of 94.4%. (2) The results of the readability analysis of the module meet the very good criteria based on the teacher's response of 97.5% and the student's response of 83.6%. (3) The results of the feasibility analysis of the module based on the teacher's response of 95% and the student's response of 82.1% indicate the module is very feasible. (4) The results of the analysis of the effectiveness of the module to improve students' cognitive learning outcomes are the N-gain value of 0.70 with high criteria. The results of this study indicate that the observation-based hybrid learning module is feasible and effective to be used as a learning media for biodiversity material to improve students' cognitive learning outcomes.
Interactive E-book Peat Ecosystem on Science Learning in Junior High School
Authors: Asi Maolina , Retnoningsih Amin , Irsadi Andin
Published: March 2024

Science learning on global warming and climate change integrated with Socio Scientific Issues of peat ecosystems is needed to increase students' knowledge of the environment. Learning uses interactive e-books that contain material in the form of text, images, and videos. This study aims to determine: (1) Validation of media and material experts; (2) Teacher's response; (3) Student response. The research subjects were two science teachers and ten seventh-grade students at SMPN 5 Palangka Raya, Central Kalimantan. The validity based on material and media experts is 91.2% on average, with very good criteria. The teacher's response to interactive e-books is in the 86.25% category with very good criteria. The average student response to interactive e-books is 78%, with a very good criteria—interactive e-book Valid and effective interactive e-book used in science learning.
Scientific Attitude Assessment Instruments Using Self-Assessment in Project-Based Learning Development
Authors: Fathayati Siti , Isnaeni Wiwi , Marianti Aditya
Published: March 2024

Scientific attitude is very important in learning activities. In addition, one of the learning objectives stated that students must have character. Students must be able to solve problems scientifically to form a good character or attitude. Such learning can be realized by using contextual learning such as project-based learning, as well as using standard scientific attitude assessment instruments. However, this affective assessment has been less emphasized. Most educators prioritize cognitive aspects in their assessment activities. For this reason, it is necessary to develop a scientific attitude assessment using self & peer assessment in project-based learning. This research is a kind of R&D research that used the ADDIE development model. The purpose of this study is to analyze the validity of the instrument, the practicality of the instrument, and the effectiveness of the developed scientific attitude assessment instrument by using self & peer assessment in project-based learning. The sample used in this study was class VII A and B SMP N 04 Lambu Kibang totaling 48 students. The lesson taught was about environmental pollution. The results of the validity of the instrument analyzed using the CVR obtained 0.9. This means that the instrument validity was good. The results of the instrument's effectiveness can be seen from the scientific attitude that has excellent criteria. The assessment used in this study was only self-assessment because of the limited learning activities due to the COVID-19 pandemic. The first learning step is having a scientific attitude of critical thinking, responsibility, and care for the environment. The second is having curiosity, perseverance, and responsibility. The third is having curiosity, critical thinking, and being objective. In the fourth learning step, the scientific attitudes that have excellent criteria are the attitude of being curious, objective, and persevering. The fifth learning step is being disciplined, caring for the environment, and having a critical thinking attitude. The sixth is an attitude of curiosity, perseverance, and responsibility.
Development of Guided Inquiry-Based Digestive System Teaching Materials to Improve Critical Thinking and Scientific Attitudes
Authors: Afridah Ayu , Iswari Retno Sri , Lisdiana Lisdiana
Published: March 2024

Difficulty in understanding the material and the decline in student learning outcomes can be managed by developing teaching materials tailored to the needs of students. This study aims to develop guided inquiry-based digestive system teaching materials as a source of student learning to improve student's critical thinking and scientific attitude. The method used in this research is the Research and Development (R&D) with the steps used are: 1) Identify potential and problems; 2) collecting data; 3) product design; 4) design validation; 5) main product revision design; 6) small-scale trial; 7) second product revision; 8) wide-scale test; 9) product revision; 10) final product. Class Students research subjects XI MIPA 4 and XI MIPA 5 SMAN 5 Cirebon with 60 students as subject. The results showed: (1) guided inquiry-based teaching material products developed based on the guided inquiry syntax; (2) the validity of teaching materials based on the validation scores of material and media experts, respectively 95% and 96.25% with very valid criteria; (3) guided inquiry-based teaching materials based on results of the analysis of the description test and the analysis of the scientific attitude assessment question, it shows that teaching material effectively improve the learning outcomes of student’s critical thinking and scientific attitude. Based on the results of the study, it can be concluded that the digestive system teaching materials developed have characteristics based on the guided inquiry syntax, including: formulate the problem, make a hypothesis, planning an experiment, collecting data and conclusion, very valid and effective teaching materials improve critical thinking and scientific attitude of students.
Effectiveness of Digital Heat Teaching Materials Based on Science, Environment, Technology, Society (SETS) to Improve Science Literacy of Junior High School Students
Authors: Astuti Heny Yuliana , Nugroho Sunyoto Eko , Astuti Budi
Published: March 2024

Nowadays, students need scientific literacy to develop skills to deal with technological developments in the industrial era 4.0. According to several studies, the scientific literacy of Junior High School and Islamic Junior High School students in various regions in Indonesia is in the medium and low categories. Innovative teaching materials appropriate for use in online learning are digital teaching materials. The development of SETS-based digital teaching materials is one of the efforts to improve students' scientific literacy in an online learning. The purpose of this research is to analyze how the validity, readability, and effectiveness of SETS based digital heat teaching materials improve the scientific literacy of Junior High School students. The method employed in this research was the Research and Development (R&D. It took the research sample from seventh-grade students of State Junior High School 3 Juwana by selecting three classes totalling 90 students. The expert validation of teaching materials using expert judgment obtained a score of 93.18% and the proof of media experts received 92.65%, indicating that teaching materials were suitable for learning media. The readability test results to the teaching materials using the gap test showed that the teaching materials were easy to understand. The results of the N-gain test from the pretest and posttest scores obtained a score of 0.706, which indicated that the enhancement of student’s scientific literacy was in the high category. Based on these result, it can be concluded that SETS-based digital teaching materials were effective in improving the scientific literacy of Junior High School students.