bluuebunny/crossref_metadata_2025 huggingface dataset:
Body Weight, Physical Activity, and Risk of Cancer in Lynch Syndrome
Authors: Sievänen Tero , Törmäkangas Timo , Laakkonen Eija K. , Mecklin Jukka-Pekka , Pylvänäinen Kirsi , Seppälä Toni T. , Peltomäki Päivi , Sipilä Sarianna , Sillanpää Elina
Published: April 2021

Lynch syndrome (LS) increases cancer risk. There is considerable individual variation in LS cancer occurrence, which may be moderated by lifestyle factors, such as body weight and physical activity (PA). The potential associations of lifestyle and cancer risk in LS are understudied. We conducted a retrospective study with cancer register data to investigate associations between body weight, PA, and cancer risk among Finnish LS carriers. The participants (n = 465, 54% women) self-reported their adulthood body weight and PA at 10-year intervals. Overall cancer risk and colorectal cancer (CRC) risk was analyzed separately for men and women with respect to longitudinal and near-term changes in body weight and PA using extended Cox regression models. The longitudinal weight change was associated with an increased risk of all cancers (HR 1.02, 95% CI 1.00–1.04) and CRC (HR 1.03, 1.01–1.05) in men. The near-term weight change was associated with a lower CRC risk in women (HR 0.96, 0.92–0.99). Furthermore, 77.6% of the participants retained their PA category over time. Men in the high-activity group had a reduced longitudinal cancer risk of 63% (HR 0.37, 0.15–0.98) compared to men in the low-activity group. PA in adulthood was not associated with cancer risk among women. These results emphasize the role of weight maintenance and high-intensity PA throughout the lifespan in cancer prevention, particularly in men with LS.
Sleep Disorders and Psychological Profile in Oral Cancer Survivors: A Case-Control Clinical Study
Authors: Gasparro Roberta , Calabria Elena , Coppola Noemi , Marenzi Gaetano , Sammartino Gilberto , Aria Massimo , Mignogna Michele Davide , Adamo Daniela
Published: April 2021

Quality of sleep (QoS) and mood may impair oral cancer survivors’ wellbeing, however few evidences are currently available. Therefore, we aimed to assess the prevalence of sleep disorders, anxiety and depression among five-year oral cancer survivors (OC survivors). 50 OC survivors were compared with 50 healthy subjects matched for age and sex. The Pittsburgh Sleep Quality Index (PSQI), the Epworth Sleepiness Scale (ESS), the Hamilton Rating Scales for Depression and Anxiety (HAM-D, HAM-A), the Numeric Rating Scale (NRS), the Total Pain Rating Index (T-PRI) were administered. The global score of the PSQI, ESS, HAM-A, HAM-D, NRS, T-PRI, was statistically higher in the OC survivors than the controls (p-value: <0.001). QoS of OC survivors was significantly impaired, especially with regard to some PSQI sub-items as the subjective sleep quality, sleep latency and daytime dysfunction (p-value: 0.001, 0.029, 0.004). Moreover, poor QoS was negatively correlated with years of education (p-value: 0.042 *) and positively correlated with alcohol consumption (p-value: 0.049 *) and with the use of systemic medications (p-value: 0.044 *). Sleep disorders and mood disorders are common comorbidities in OC survivors; therefore, early assessment and management before, during and after treatment should be performed in order to improve the quality of life of OC survivors.
Ipilimumab and Stereotactic Radiosurgery with CyberKnife® System in Melanoma Brain Metastases: A Retrospective Monoinstitutional Experience
Authors: Borzillo Valentina , Di Franco Rossella , Giannarelli Diana , Cammarota Fabrizio , Scipilliti Esmeralda , D'Ippolito Emma , Petito Angela , Serra Marcello , Falivene Sara , Grimaldi Antonio M. , Simeone Ester , Festino Lucia , Vanella Vito , Trojaniello Claudia , Vitale Maria Grazia , Madonna Gabriele , Ascierto Paolo A. , Muto Paolo
Published: April 2021

The median overall survival (OS) and local control (LC) of patients with melanoma brain metastases (MBMs) are poor even with immune checkpoint inhibitors and/or radiotherapy (RT). The aims of the study were to evaluate the association and timing of stereotactic radiotherapy (SRT)/radiosurgery (SRS) performed with the CyberKnife® System and ipilimumab (IPI). A total of 63 MBMs patients were analyzed: 53 received RT+IPI and 10 RT alone. Therefore, the patients were divided into four groups: RT PRE-PI (>4 weeks before IPI) (18), RT CONC-IPI (4 weeks before/between first and last cycle/within 3 months of last cycle of IPI) (20), RT POST-IPI (>3 months after IPI) (15), and NO-IPI (10). A total of 127 lesions were treated: 75 with SRS (one fraction) and 24 with SRT (three to five fractions). The median follow-up was 10.6 months. The median OS was 10.6 months for all patients, 10.7 months for RT+IPI, and 3.3 months for NO-IPI (p = 0.96). One-year LC was 50% for all patients, 56% for RT+IPI, and 18% for NO-IPI (p = 0.08). The 1-year intracranial control was 45% for all patients, 44% for RT+IPI, and 51% for NO-IPI (p = 0.73). IPI with SRS/SRT in MBMs treatment could improve LC. However, the impact and timing of the two modalities on patients’ outcomes are still unclear.
Feasibility of Non-Exposure Simple Suturing Endoscopic Full-Thickness Resection in Comparison with Laparoscopic Endoscopic Cooperative Surgery for Gastric Subepithelial Tumors: Results of Two Independent Prospective Trials
Authors: Eom Bang Wool , Kim Chan Gyoo , Kook Myeong-Cherl , Yoon Hong Man , Ryu Keun Won , Kim Young-Woo , Rho Ji Yoon , Kim Young-Il , Lee Jong Yeul , Choi Il Ju
Published: April 2021

Recently, nonexposure simple suturing endoscopic full-thickness resection (NESS-EFTR) method was developed to avoid tumor exposure to the peritoneal cavity. The aim of this study is to compare the short-term outcomes of the NESS-EFTR method with those of laparoscopic and endoscopic cooperative surgery (LECS) for gastric subepithelial tumors (SETs). A prospective single-center trial of LECS for gastric SETs was performed from March 2012 to October 2013 with a separate prospective trial of NESS-EFTR performed from August 2015 to June 2017, enrolling 15 patients each. Among the 30 enrolled patients, 14 who underwent LECS and 11 who underwent NESS-EFTR were finally included in the analysis. The rate of complete resection and successful closure was 100% in both groups. The operating time was longer for NESS-EFTR group than for LECS (110 vs. 189 min; p < 0.0001). There were no postoperative complications except one case of transient fever in the NESS-EFTR group. One patient in the LECS group had peritoneal seeding of gastrointestinal stromal tumor at 17 months postoperatively, and there was no other recurrence. Although NESS-EFTR had long operating and procedure times, it was feasible for patients with gastric SETs requiring a nonexposure technique.
Ultra-High Dose Rate Transmission Beam Proton Therapy for Conventionally Fractionated Head and Neck Cancer: Treatment Planning and Dose Rate Distributions
Authors: van Marlen Patricia , Dahele Max , Folkerts Michael , Abel Eric , Slotman Ben J. , Verbakel Wilko
Published: April 2021

Transmission beam (TB) proton therapy (PT) uses single, high energy beams with Bragg-peak behind the target, sharp penumbras and simplified planning/delivery. TB facilitates ultra-high dose-rates (UHDRs, e.g., ≥40 Gy/s), which is a requirement for the FLASH-effect. We investigated (1) plan quality for conventionally-fractionated head-and-neck cancer treatment using spot-scanning proton TBs, intensity-modulated PT (IMPT) and photon volumetric-modulated arc therapy (VMAT); (2) UHDR-metrics. VMAT, 3-field IMPT and 10-field TB-plans, delivering 70/54.25 Gy in 35 fractions to boost/elective volumes, were compared (n = 10 patients). To increase spot peak dose-rates (SPDRs), TB-plans were split into three subplans, with varying spot monitor units and different gantry currents. Average TB-plan organs-at-risk (OAR) sparing was comparable to IMPT: mean oral cavity/body dose were 4.1/2.5 Gy higher (9.3/2.0 Gy lower than VMAT); most other OAR mean doses differed by <2 Gy. Average percentage of dose delivered at UHDRs was 46%/12% for split/non-split TB-plans and mean dose-averaged dose-rate 46/21 Gy/s. Average total beam-on irradiation time was 1.9/3.8 s for split/non-split plans and overall time including scanning 8.9/7.6 s. Conventionally-fractionated proton TB-plans achieved comparable OAR-sparing to IMPT and better than VMAT, with total beam-on irradiation times <10s. If a FLASH-effect can be demonstrated at conventional dose/fraction, this would further improve plan quality and TB-protons would be a suitable delivery system.
The Effect of Mg and Zn Dopants on Pt/Al2O3 for the Dehydrogenation of Perhydrodibenzyltoluene
Authors: Garidzirai Rudaviro , Modisha Phillimon , Shuro Innocent , Visagie Jacobus , van Helden Pieter , Bessarabov Dmitri
Published: April 2021

The effects of Mg and Zn dopants on the catalytic performance of Pt/Al2O3 catalyst were investigated for dehydrogenation of perhydrodibenzyltoluene (H18-DBT) as a liquid organic hydrogen carrier. Al2O3 supports were modified with Mg and Zn to produce Mg-Al2O3 and Zn-Al2O3 with a target loading of 3.8 wt.% for dopants. The modified supports were impregnated with chloroplatinic acid solution to produce the catalysts Pt/Al2O3, Pt/Mg-Al2O3 and Pt/Zn-Al2O3 of 0.5 wt.% Pt loading. Thereafter, the catalysts were characterised using inductively coupled plasma- optical emission spectrometry, scanning electron microscopy-energy dispersive X-ray spectroscopy, hydrogen temperature-programmed reduction, carbon-monoxide pulse chemisorption, ammonia temperature-programmed desorption, X-ray diffraction and transmission electron microscopy. The dehydrogenation experiments were performed using a horizontal plug flow reactor system and the catalyst time-on-stream was 22 h. Pt/Mg-Al2O3 showed the highest average hydrogen flowrate of 29 nL/h, while an average of 27 nL/h was obtained for both Pt/Al2O3 and Pt/Zn-Al2O3. This has resulted in a hydrogen yield of 80% for Pt/Mg-Al2O3, 71% for Pt/Zn-Al2O3 and 73% for Pt/Al2O3. In addition, the conversion of H18-DBT ranges from 99% to 92%, Pt 97–90% and 96–90% for Pt/Mg-Al2O3, Pt/Zn-Al2O3 and Pt/Al2O3, respectively. Following the latter catalyst order, the selectivity to dibenzyltoluene (H0-DBT) ranges from 78% to 57%, 75–51% and 71–45%. Therefore, Pt/Mg-Al2O3 showed improved catalytic performance towards dehydrogenation of H18-DBT.
Anti-VEGF Drugs Influence Epigenetic Regulation and AMD-Specific Molecular Markers in ARPE-19 Cells
Authors: Hamid Mohamed A. , Moustafa M. Tarek , Nashine Sonali , Costa Rodrigo Donato , Schneider Kevin , Atilano Shari R. , Kuppermann Baruch D. , Kenney M. Cristina
Published: April 2021

Our study assesses the effects of anti-VEGF (Vascular Endothelial Growth Factor) drugs and Trichostatin A (TSA), an inhibitor of histone deacetylase (HDAC) activity, on cultured ARPE-19 (Adult Retinal Pigment Epithelial-19) cells that are immortalized human retinal pigment epithelial cells. ARPE-19 cells were treated with the following anti-VEGF drugs: aflibercept, ranibizumab, or bevacizumab at 1× and 2× concentrations of the clinical intravitreal dose (12.5 μL/mL and 25 μL/mL, respectively) and analyzed for transcription profiles of genes associated with the pathogenesis age-related macular degeneration (AMD). HDAC activity was measured using the Fluorometric Histone Deacetylase assay. TSA downregulated HIF-1α and IL-1β genes, and upregulated BCL2L13, CASPASE-9, and IL-18 genes. TSA alone or bevacizumab plus TSA showed a significant reduction of HDAC activity compared to untreated ARPE-19 cells. Bevacizumab alone did not significantly alter HDAC activity, but increased gene expression of SOD2, BCL2L13, CASPASE-3, and IL-18 and caused downregulation of HIF-1α and IL-18. Combination of bevacizumab plus TSA increased gene expression of SOD2, HIF-1α, GPX3A, BCL2L13, and CASPASE-3, and reduced CASPASE-9 and IL-β. In conclusion, we demonstrated that anti-VEGF drugs can: (1) alter expression of genes involved in oxidative stress (GPX3A and SOD2), inflammation (IL-18 and IL-1β) and apoptosis (BCL2L13, CASPASE-3, and CASPASE-9), and (2) TSA-induced deacetylation altered transcription for angiogenesis (HIF-1α), apoptosis, and inflammation genes.
FGF/FGFR Pathways in Multiple Sclerosis and in Its Disease Models
Authors: Rajendran Ranjithkumar , Böttiger Gregor , Stadelmann Christine , Karnati Srikanth , Berghoff Martin
Published: April 2021

Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system (CNS) affecting more than two million people worldwide. In MS, oligodendrocytes and myelin sheaths are destroyed by autoimmune-mediated inflammation, while remyelination is impaired. Recent investigations of post-mortem tissue suggest that Fibroblast growth factor (FGF) signaling may regulate inflammation and myelination in MS. FGF2 expression seems to correlate positively with macrophages/microglia and negatively with myelination; FGF1 was suggested to promote remyelination. In myelin oligodendrocyte glycoprotein (MOG)35–55-induced experimental autoimmune encephalomyelitis (EAE), systemic deletion of FGF2 suggested that FGF2 may promote remyelination. Specific deletion of FGF receptors (FGFRs) in oligodendrocytes in this EAE model resulted in a decrease of lymphocyte and macrophage/microglia infiltration as well as myelin and axon degeneration. These effects were mediated by ERK/Akt phosphorylation, a brain-derived neurotrophic factor, and downregulation of inhibitors of remyelination. In the first part of this review, the most important pharmacotherapeutic principles for MS will be illustrated, and then we will review recent advances made on FGF signaling in MS. Thus, we will suggest application of FGFR inhibitors, which are currently used in Phase II and III cancer trials, as a therapeutic option to reduce inflammation and induce remyelination in EAE and eventually MS.
Heat Exchanger Network Retrofit of an Oleochemical Plant through a Cost and Energy Efficiency Approach
Authors: Trisha Valli , Koh Kai Seng , Ng Lik Yin , Chok Vui Soon
Published: April 2021

Limited research of heat integration has been conducted in the oleochemical field. This paper attempts to evaluate the performance of an existing heat exchanger network (HEN) of an oleochemical plant at 600 tonnes per day (TPD) in Malaysia, in which the emphases are placed on the annual saving and reduction in energy consumption. Using commercial HEN numerical software, ASPEN Energy Analyzer v10.0, it was found that the performance of the current HEN in place is excellent, saving over 80% in annual costs and reducing energy consumption by 1,882,711 gigajoule per year (GJ/year). Further analysis of the performance of the HEN was performed to identify the potential optimisation of untapped heating/cooling process streams. Two cases, which are the most cost-effective and energy efficient, were proposed with positive results. However, the second case performed better than the first case, at a lower payback time (0.83 year) and higher annual savings (0.20 million USD/year) with the addition of one heat exchanger at a capital cost of USD 134,620. The first case had a higher payback time (4.64 years), a lower annual saving (0.05 million USD/year) and three additional heaters at a capital cost of USD 193,480. This research has provided a new insight into the oleochemical industry in which retrofitting the HEN can further reduce energy consumption, which in return will reduce the overall production cost of oleochemical commodities. This is particularly crucial in making the product more competitive in its pricing in the global market.
Molecular Docking and Molecular Dynamics Simulation Studies of Quinoline-3-Carboxamide Derivatives with DDR Kinases–Selectivity Studies towards ATM Kinase
Authors: Ravi Srimadhavi , Priya Bhanu , Dubey Pankaj , Thiruvenkatam Vijay , Kirubakaran Sivapriya
Published: April 2021

Quinoline-3-carboxamides are an essential class of drug-like small molecules that are known to inhibit the phosphatidylinositol 3-kinase-related kinases (PIKK) family kinases. The quinoline nitrogen is shown to bind to the hinge region of the kinases, making them competitive inhibitors of adenosine triphosphate (ATP). We have previously designed and synthesized quinoline-3-carboxamides as potential ataxia telangiectasia mutated (ATM) kinase inhibitors to function as an adjuvant treatment with DNA damaging agents. This article discusses the molecular docking studies performed with these derivatives with the DNA damage and response (DDR) kinases-ATM, ataxia telangiectasia and rad3 related (ATR), and DNA dependent protein kinase catalytic subunit (DNA-PKcs) and highlights their selectivity towards ATM kinase. Docking studies were also performed with mTOR and PI3Kγ, which are close homologs of the DDR kinases. Molecular dynamics simulations were performed for one of the inhibitors against all the enzymes to establish the stability of the interactions involved. Finally, the absorption, distribution, metabolism, and excretion (ADME) properties of the inhibitors were predicted using the QikProp manual in Maestro. In conclusion, the molecules synthesized showed high selectivity towards the ATM kinase in comparison with the other kinases, though the sequence similarity between them was relatively high.
The Impact of Structural Defects on Iodine Adsorption in UiO-66
Authors: Maddock John , Kang Xinchen , Liu Lifei , Han Buxing , Yang Sihai , Schröder Martin
Published: April 2021

Radioactive I2 (iodine) produced as a by-product of nuclear fission poses a risk to public health if released into the environment, and it is thus vital to develop materials that can capture I2 vapour. Materials designed for the capture and storage of I2 must have a high uptake capacity and be stable for long-term storage due the long half-life of 129I. UiO-66 is a highly stable and readily tuneable metal-organic framework (MOF) into which defect sites can be introduced. Here, a defective form of UiO-66 (UiO-66-FA) was synthesised and the presence of missing cluster moieties confirmed using confocal fluorescence microscopy and gas sorption measurements. The uptake of I2 vapour in UiO-66-FA was measured using thermal gravimetric analysis coupled mass spectrometry (TGA-MS) to be 2.25 g g−1, almost twice that (1.17 g g−1) of the pristine UiO-66. This study will inspire the design of new efficient I2 stores based upon MOFs incorporating structural defects.
Low-Temperature Epitaxial Growth of AlN Thin Films on a Mo Electrode/Sapphire Substrate Using Reactive Sputtering
Authors: Kim Jihong
Published: April 2021

High-crystalline aluminum nitride (AlN) thin films are essential for device applications, and epitaxial growth is a promising approach to improve their crystalline quality. However, a high substrate temperature is usually required for the epitaxial growth, which is not compatible with the complementary metal-oxide-semiconductor (CMOS) process. Furthermore, it is very difficult to obtain epitaxial AlN thin films on the deposited metal layers that are sometimes necessary for the bottom electrodes. In this work, epitaxial AlN thin films were successfully prepared on a molybdenum (Mo) electrode/sapphire substrate using reactive sputtering at a low substrate temperature. The structural properties, including the out-of-plane and in-plane relationships between the AlN thin film and the substrate, were investigated using X-ray diffraction (XRD) 2θ-ω, rocking curve, and pole figure scans. Additional analyses using scanning electron microscopy (SEM), atomic force microscopy (AFM), and transmission electron microscopy (TEM) were also carried out. It was shown that highly c-axis-oriented AlN thin films were grown epitaxially on the Mo/sapphire substrate with an in-plane relationship of AlN [112¯0]//sapphire [101¯0]. This epitaxial growth was attributed to the highly ordered and oriented Mo electrode layer grown on the sapphire substrate. In contrast, the AlN deposition on the Mo/SiO2/Si substrate under the same conditions caused poorly oriented films with a polycrystalline structure. There coexisted two different low-crystalline phases of Mo (110) and Mo (211) in the Mo layer on the SiO2/Si substrate, which led to the high mosaicity and polycrystalline structure of the AlN thin films.
Printing with Natural Dye Extracted from Impatiens glandulifera Royle
Authors: Klančnik Maja
Published: April 2021

Invasive alien plants that damagingly overgrow native ecosystems can be beneficially used to produce natural dyes. Natural dyes are healthier and more environmentally friendly than synthetic dyes, so their use on textiles and other products that come into contact with humans is desirable. In this study, the possibility of using a natural dye extracted from the purple petals of the invasive plant Impatiens glandulifera Royle (Himalayan balsam) for screen printing on various substrates; woven fabrics and different papers made from virgin fibers, recycled fibers, and from fibers of Japanese knotweed, was investigated. The prints were evaluated by color measurements and fastness properties. With the violet dye extract, purple-brown prints were obtained on papers made from Japanese knotweed, and more brown prints on other substrates. They had excellent rub fastness but faded significantly when exposed to light. The wash fastness of the prints on cotton fabrics was moderate and poor on polyester fabrics, but the prints had good resistance to wet ironing. The addition of acid to the printing paste resulted in a lighter violet color, the addition of alkali caused a drastic color change to green, both additives increased the light fastness of the prints but reduced the fastness on fabrics to wet treatments.
The Effect of Crystallization and Phase Transformation on the Mechanical and Electrochemical Corrosion Properties of Ni-P Coatings
Authors: Buchtík Martin , Doskočil Leoš , Brescher Roman , Doležal Pavel , Másilko Jiří , Wasserbauer Jaromír
Published: April 2021

This paper deals with the study of the crystallization and phase transformation of Ni-P coatings deposited on AZ91 magnesium alloy. Prepared samples were characterized in terms of surface morphology and elemental composition by means of scanning electron microscopy with energy-dispersive spectroscopy analysis. The results of X-ray diffraction analysis and differential scanning calorimetry suggested that increasing the phosphorus content caused Ni-P coatings to develop an amorphous character. The crystallization of Ni was observed at 150, 250, and 300 °C for low-, medium- and high-phosphorus coatings, respectively. The Ni crystallite size increased with increasing temperature and decreasing P content. Conversely, the presence of the Ni3P phase was observed at a maximum peak of 320 °C for the high-phosphorus coating, whereas the crystallization of the Ni3P phase shifted to higher temperatures with decreasing P content. The Ni3P crystallite size increased with increasing temperature and increasing P content. An increase in microhardness due to the arrangement of Ni atoms and Ni3P precipitation was observed. The deposition of as-deposited Ni-P coatings led to an improvement in the corrosion resistance of AZ91. However, the heat treatment of coatings resulted in a deterioration in corrosion properties due to the formation of microcracks.
First Approach to Measure Interfacial Rheology at High-Pressure Conditions by the Oscillating Drop Technique
Authors: Barrabino Albert , Holt Torleif , Bjørkvik Bård , Lindeberg Erik
Published: April 2021

An oscillating drop rheometer capable of operating under conditions of high pressure and high temperature has been built. The oscillating drop mechanism was able to support pressures as high as 1300 bar and successfully performed oscillations at constant pressure. Apparent elastic and viscous complex moduli were measured for a system of CO2 and synthetic seawater containing 100 ppm of a linear alkyl ethoxylate surfactant for different pressures and temperatures. The moduli had strong dependencies on both pressure and temperature. At temperatures of 40 and 80 °C, the apparent elastic modulus passed through a maximum for pressures between 100 and 300 bar. The harmonic distortion of the oscillations was calculated for all measurements, and it was found that drop oscillations below ca. 2.6 µL caused distortions above 10% due to a mechanical backlash of the motor.
Axisymmetric Slow Motion of a Porous Spherical Particle in a Viscous Fluid Using Time Fractional Navier–Stokes Equation
Authors: Prakash Jai , Satyanarayana Chirala
Published: April 2021

In this paper, we present the unsteady translational motion of a porous spherical particle in an incompressible viscous fluid. In this case, the modified Navier–Stokes equation with fractional order time derivative is used for conservation of momentum external to the particle whereas modified Brinkman equation with fractional order time derivative is used internal to the particle to govern the fluid flow. Stress jump condition for the tangential stress along with continuity of normal stress and continuity of velocity vectors is used at the porous–liquid interface. The integral Laplace transform technique is employed to solve the governing equations in fluid and porous regions. Numerical inversion code in MATLAB is used to obtain the solution of the problem in the physical domain. Drag force experienced by the particle is obtained. The numerical results have been discussed with the aid of graphs for some specific flows, namely damping oscillation, sine oscillation and sudden motion. Our result shows a significant contribution of the jump coefficient and the fractional order parameter to the drag force.
CAT-CAD: A Computer-Aided Diagnosis Tool for Cataplexy
Authors: Bartolini Ilaria , Di Luzio Andrea
Published: April 2021

Narcolepsy with cataplexy is a severe lifelong disorder characterized, among others, by sudden loss of bilateral face muscle tone triggered by emotions (cataplexy). A recent approach for the diagnosis of the disease is based on a completely manual analysis of video recordings of patients undergoing emotional stimulation made on-site by medical specialists, looking for specific facial behavior motor phenomena. We present here the CAT-CAD tool for automatic detection of cataplexy symptoms, with the double aim of (1) supporting neurologists in the diagnosis/monitoring of the disease and (2) facilitating the experience of patients, allowing them to conduct video recordings at home. CAT-CAD includes a front-end medical interface (for the playback/inspection of patient recordings and the retrieval of videos relevant to the one currently played) and a back-end AI-based video analyzer (able to automatically detect the presence of disease symptoms in the patient recording). Analysis of patients’ videos for discovering disease symptoms is based on the detection of facial landmarks, and an alternative implementation of the video analyzer, exploiting deep-learning techniques, is introduced. Performance of both approaches is experimentally evaluated using a benchmark of real patients’ recordings, demonstrating the effectiveness of the proposed solutions.
A Review of the Melting Curves of Transition Metals at High Pressures Using Static Compression Techniques
Authors: Parisiades Paraskevas
Published: April 2021

The accurate determination of melting curves for transition metals is an intense topic within high pressure research, both because of the technical challenges included as well as the controversial data obtained from various experiments. This review presents the main static techniques that are used for melting studies, with a strong focus on the diamond anvil cell; it also explores the state of the art of melting detection methods and analyzes the major reasons for discrepancies in the determination of the melting curves of transition metals. The physics of the melting transition is also discussed.
Milk Fat Globule Membrane Proteome and Micronutrients in the Milk Lipid Fraction: Insights into Milk Bioactive Compounds
Authors: Manoni Michele , Cattaneo Donata , Mazzoleni Sharon , Giromini Carlotta , Baldi Antonella , Pinotti Luciano
Published: April 2021

Milk lipids are composed of milk fat globules (MFGs) surrounded by the milk fat globule membrane (MFGM). MFGM protects MFGs from coalescence and enzymatic degradation. The milk lipid fraction is a “natural solvent” for macronutrients such as phospholipids, proteins and cholesterol, and micronutrients such as minerals and vitamins. The research focused largely on the polar lipids of MFGM, given their wide bioactive properties. In this review we discussed (i) the composition of MFGM proteome and its variations among species and phases of lactation and (ii) the micronutrient content of human and cow’s milk lipid fraction. The major MFGM proteins are shared among species, but the molecular function and protein expression of MFGM proteins vary among species and phases of lactation. The main minerals in the milk lipid fraction are iron, zinc, copper and calcium, whereas the major vitamins are vitamin A, β-carotene, riboflavin and α-tocopherol. The update and the combination of this knowledge could lead to the exploitation of the MFGM proteome and the milk lipid fraction at nutritional, biological or technological levels. An example is the design of innovative and value-added products, such as MFGM-supplemented infant formulas.
Design Preconditions for Product–Service Integration
Authors: Dewit Ivo , Jacoby Alexis , Matthyssens Paul
Published: April 2021

User expectations regarding new products and services are evolving rapidly, forcing innovative organizations to explore new avenues for innovation, combining products and services. This paper focuses on the integrative design of product–service systems (PSSs) and builds on the servitization and service-based innovation literature. Many tools have been proposed for designing integrated PSS, with the intent to generate economic and/or sustainable impact. In this article, we focus on tools being used for bringing the user experience and intangibles in the design process. Although the literature is rich with tools and methods to optimize the PSS design process, it does not consider the full array of methods and their impact. This lack of research attention might hinder organizations developing PSS. Using in-depth interviews, this qualitative research systematically combines the extant conceptual literature on PSS design tools and processes with expert insights, thereby contextualizing how to lower thresholds in PSS design processes and how to increase the effectiveness of PSS design tools. The paper contributes to the literature on servitization and PSS by explicitly identifying twenty-one preconditions that support the PSS design process while integrating product and service innovation in close relation to the end-user.
Toxicology of Blister Agents: Is Melatonin a Potential Therapeutic Option?
Authors: Romero Alejandro , Ramos Eva , López-Muñoz Francisco , De Los Ríos Cristóbal , Egea Javier , Gil-Martín Emilio , Pita René , Torrado Juan J. , Serrano Dolores R. , Juberias Antonio
Published: April 2021

Blister or vesicant chemical warfare agents (CWAs) have been widely used in different military conflicts, including World War I and the Iran-Iraq War. However, their mechanism of action is not fully understood. Sulfur and nitrogen mustard exert toxic effects not only through the alkylation of thiol-bearing macromolecules, such as DNA and proteins, but also produce free radicals that can develop direct toxic effects in target organs such as the eyes, skin, and respiratory system. The lack of effective treatments against vesicant CWAs-induced injury makes us consider, in this complex scenario, the use and development of melatonin-based therapeutic strategies. This multifunctional indoleamine could facilitate neutralization of the oxidative stress, modulate the inflammatory response, and prevent the DNA damage, as well as the long-term health consequences mediated by vesicant CWAs-induced epigenetic mechanisms. In this context, it would be essential to develop new galenic formulations for the use of orally and/or topically applied melatonin for the prophylaxis against vesicant CWAs, as well as the development of post-exposure treatments in the near future.
Anti-Angiogenic Therapy: Albumin-Binding Proteins Could Mediate Mechanisms Underlying the Accumulation of Small Molecule Receptor Tyrosine Kinase Inhibitors in Normal Tissues with Potential Harmful Effects on Health
Authors: Ghinea Nicolae
Published: April 2021

Anti-angiogenics currently used in cancer therapy target angiogenesis by two major mechanisms: (i) neutralizing angiogenic factors or their receptors by using macromolecule anti-angiogenic drugs (e.g., therapeutic antibodies), and (ii) blocking intracellularly the activity of receptor tyrosine kinases with small molecule (Mr < 1 kDa) inhibitors. Anti-angiogenics halt the growth and spread of cancer, and significantly prolong the disease-free survival of the patients. However, resistance to treatment, insufficient efficacy, and toxicity limit the success of this antivascular therapy. Published evidence suggests that four albumin-binding proteins (ABPs) (gp18, gp30, gp60/albondin, and secreted protein acidic and cysteine-rich (SPARC)) could be responsible for the accumulation of small molecule receptor tyrosine kinase inhibitors (RTKIs) in normal organs and tissues and therefore responsible for the side effects and toxicity associated with this type of cancer therapy. Drawing attention to these studies, this review discusses the possible negative role of albumin as a drug carrier and the rationale for a new strategy for cancer therapy based on follicle-stimulating hormone receptor (FSHR) expressed on the luminal endothelial cell surface of peritumoral blood vessels associated with the major human cancers. This review should be relevant to the audience and the field of cancer therapeutics and angiogenesis/microvascular modulation-based interventions.
The Impact of Oral Health on Respiratory Viral Infection
Authors: Tada Akio , Senpuku Hidenobu
Published: April 2021

Influenza virus and severe acute respiratory syndrome coronavirus (SARS-CoV-2) have caused respiratory diseases worldwide. Coronavirus disease 2019 (COVID-19) is now a global health concern requiring emergent measures. These viruses enter the human body through the oral cavity and infect respiratory cells. Since the oral cavity has a complex microbiota, influence of oral bacteria on respiratory virus infection is considered. Saliva has immune molecules which work as the front line in the biophylactic mechanism and has considerable influence on the incidence and progression of respiratory viral infection. Salivary scavenger molecules, such as gp340 and sialic acid, have been reported to exert anti-influenza virus activity. Salivary secretory immunoglobulin A (SIgA) has potential to acquire immunity against these viruses. Biological features of the oral cavity are thought to affect viral infection in respiratory organs in various ways. In this review, we reviewed the literature addressing the impact of oral conditions on respiratory infectious diseases caused by viruses.
Genus-Physiognomy-Ecosystem (GPE) System for Satellite-Based Classification of Plant Communities
Authors: Sharma Ram C.
Published: April 2021

Vegetation mapping and monitoring is important as the composition and distribution of vegetation has been greatly influenced by land use change and the interaction of land use change and climate change. The purpose of vegetation mapping is to discover the extent and distribution of plant communities within a geographical area of interest. The paper introduces the Genus-Physiognomy-Ecosystem (GPE) system for the organization of plant communities from the perspective of satellite remote sensing. It was conceived for broadscale operational vegetation mapping by organizing plant communities according to shared genus and physiognomy/ecosystem inferences, and it offers an intermediate level between the physiognomy/ecosystem and dominant species for the organization of plant communities. A machine learning and cross-validation approach was employed by utilizing multi-temporal Landsat 8 satellite images on a regional scale for the classification of plant communities at three hierarchical levels: (i) physiognomy, (ii) GPE, and (iii) dominant species. The classification at the dominant species level showed many misclassifications and undermined its application for broadscale operational mapping, whereas the GPE system was able to lessen the complexities associated with the dominant species level classification while still being capable of distinguishing a wider variety of plant communities. The GPE system therefore provides an easy-to-understand approach for the operational mapping of plant communities, particularly on a broad scale.
Mediating Role of Firm R&D in Creating Product and Process Innovation: Empirical Evidence from Norway
Authors: Sein Yee Yee , Prokop Viktor
Published: April 2021

Government funding actively engages in private R&D investment to enhance firm innovation. At the same time, firms are forced to find additional sources of competitive advantage, e.g., through cooperation based on the triple- or quadruple-helix principles. This paper analyses whether government funding and cooperation based on the triple-helix and quadruple-helix principles spur firms’ product and process innovation rather directly or indirectly, taking into account the role of firms R&D. For this purpose, we collect data from the Community Innovation Survey and analyse 5045 Norwegian firms by using partial least squares structural equation modelling. Our results confirm hypotheses that public funding and both triple-helix and quadruple-helix cooperation significantly influence firms’ research and development activities. Surprisingly, on the one hand, we showed that neither public funding nor triple- and quadruple-helix cooperation affect firms’ product innovation directly. Moreover, the results show a negative influence of government funding and triple- and quadruple-helix cooperation on Norwegian firms’ product innovation. On the other hand, process innovation is influenced positively and directly by firms’ cooperation based on the triple- and quadruple-helix principles. The results of our analyses clearly show the key role of firm’s R&D, which has proven to be a mediator of the effects of public funding and triple- and quadruple-helix cooperation on the product and process innovation activities of Norwegian firms.
5G Mobile Phone Network Introduction in Colombia
Authors: Cama-Pinto Dora , Damas Miguel , Holgado-Terriza Juan Antonio , Gómez-Mula Francisco , Calderin-Curtidor Andrés Camilo , Martínez-Lao Juan , Cama-Pinto Alejandro
Published: April 2021

The deployment of the 5G mobile network is currently booming, offering commercially available services that improve network performance metrics by minimizing network latency in countries such as the USA, China, and Korea. However, many countries around the world are still in the pilot phase promoted and regulated by government agencies. This is the case in Colombia, where the assignment of the first 5G band is planned for the third quarter of 2021. By analyzing the results of the pilot phase and the roadmap of the Colombian Ministry of Information and Communication Technologies (MinTIC), we can determine the main issues, which contribute to the deployment of 5G mobile technology as well as the plans to achieve a 5G stand-alone network from 4G networks. This is applicable to other countries in Latin America and the world. Then, our objective is to synthesize and share the most important concepts of 5G mobile technology such as the MIMO (multiple input/multiple output) antenna, RAN (Radio Access Network), C-RAN (Centralised-RAN), and frequency bands, and evaluate the current stage of its introduction in Colombia.
A High Step-Up Switched Z-Source Converter (HS-SZC) with Minimal Components Count for Enhancing Voltage Gain
Authors: Kumar Rahul , Kannan Ramani , Nor Nursyarizal Bin Mohd , Mahmud Apel
Published: April 2021

Some applications such as fuel cells or photovoltaic panels offer low output voltage, and it is essential to boost this voltage before connecting to the grid through an inverter. The Z-network converter can be used for the DC-DC conversion to enhance the output voltage of renewable energy sources. However, boosting capabilities of traditional Z-network boost converters are limited, and the utilization of higher parts count makes it bulky and expensive. In this paper, an efficient, high step-up, switched Z-source DC-DC boost converter (HS-SZC) is presented, which offers a higher boost factor at a smaller duty ratio and avoids the instability due to the saturation of inductors. In the proposed converter, the higher voltage gain is achieved by using one inductor and switch at the back end of the conventional Z-source DC-DC converter (ZSC). The idea is to utilize the output capacitor for filtering and charging and discharging loops. Moreover, the proposed converter offers a wider range of load capacity, thus minimizing the power losses and enhancing efficiency. This study simplifies the structure of conventional Z-source converters through the deployment of fewer components, and hence making it more cost-effective and highly efficient, compared to other DC-DC boost converters. Furthermore, a comparison based on the boosting capability and number of components is provided, and the performance of the proposed design is analyzed with non-ideal elements. Finally, simulation and experimental studies are carried out to evaluate and validate the performance of the proposed converter.
Challenges and New Trends in Power Electronic Devices Reliability
Authors: Chiodo Elio , De Falco Pasquale , Di Noia Luigi Pio
Published: April 2021

Power electronic devices are expected to play an ever more fundamental role in unlocking the potentialities of smart power systems and in developing more electric ground and air transportation systems [...]
Fast Motion Model of Road Vehicles with Artificial Neural Networks
Authors: Hegedüs Ferenc , Gáspár Péter , Bécsi Tamás
Published: April 2021

Nonlinear optimization-based motion planning algorithms have been successfully used for dynamically feasible trajectory planning of road vehicles. However, the main drawback of these methods is their significant computational effort and thus high runtime, which makes real-time application a complex problem. Addressing this field, this paper proposes an algorithm for fast simulation of road vehicle motion based on artificial neural networks that can be used in optimization-based trajectory planners. The neural networks are trained with supervised learning techniques to predict the future state of the vehicle based on its current state and driving inputs. Learning data is provided for a wide variety of randomly generated driving scenarios by simulation of a dynamic vehicle model. The realistic random driving maneuvers are created on the basis of piecewise linear travel velocity and road curvature profiles that are used for the planning of public roads. The trained neural networks are then used in a feedback loop with several variables being calculated by additional numerical integration to provide all the outputs of the original dynamic model. The presented model can be capable of short-term vehicle motion simulation with sufficient precision while having a considerably faster runtime than the original dynamic model.
Pointless Pose: Part Affinity Field-Based 3D Pose Estimation without Detecting Keypoints
Authors: Wang Jue , Luo Zhigang
Published: April 2021

Human pose estimation finds its application in an extremely wide domain and is therefore never pointless. We propose in this paper a new approach that, unlike any prior one that we are aware of, bypasses the 2D keypoint detection step based on which the 3D pose is estimated, and is thus pointless. Our motivation is rather straightforward: 2D keypoint detection is vulnerable to occlusions and out-of-image absences, in which case the 2D errors propagate to 3D recovery and deteriorate the results. To this end, we resort to explicitly estimating the human body regions of interest (ROI) and their 3D orientations. Even if a portion of the human body, like the lower arm, is partially absent, the predicted orientation vector pointing from the upper arm will take advantage of the local image evidence and recover the 3D pose. This is achieved, specifically, by deforming a skeleton-shaped puppet template to fit the estimated orientation vectors. Despite its simple nature, the proposed approach yields truly robust and state-of-the-art results on several benchmarks and in-the-wild data.
CO2 Intensities and Primary Energy Factors in the Future European Electricity System
Authors: Hamels Sam
Published: April 2021

The European Union strives for sharp reductions in both CO2 emissions as well as primary energy use. Electricity consuming technologies are becoming increasingly important in this context, due to the ongoing electrification of transport and heating services. To correctly evaluate these technologies, conversion factors are needed—namely CO2 intensities and primary energy factors (PEFs). However, this evaluation is hindered by the unavailability of a high-quality database of conversion factor values. Ideally, such a database has a broad geographical scope, a high temporal resolution and considers cross-country exchanges of electricity as well as future evolutions in the electricity mix. In this paper, a state-of-the-art unit commitment economic dispatch model of the European electricity system is developed and a flow-tracing technique is innovatively applied to future scenarios (2025–2040)—to generate such a database and make it publicly available. Important dynamics are revealed, including an overall decrease in conversion factor values as well as considerable temporal variability at both the seasonal and hourly level. Furthermore, the importance of taking into account imports and carefully considering the calculation methodology for PEFs are both confirmed. Future estimates of the CO2 emissions and primary energy use associated with individual electrical loads can be meaningfully improved by taking into account these dynamics.
Assessing Future Water Demand and Associated Energy Input with Plausible Scenarios for Water Service Providers (WSPs) in Sub-Saharan Africa
Authors: Macharia Pauline , Kitaka Nzula , Yillia Paul , Kreuzinger Norbert
Published: April 2021

This study examined the current state of water demand and associated energy input for water supply against a projected increase in water demand in sub-Saharan Africa. Three plausible scenarios, namely, Current State Extends (CSE), Current State Improves (CSI) and Current State Deteriorates (CSD) were developed and applied using nine quantifiable indicators for water demand projections and the associated impact on energy input for water supply for five Water Service Providers (WSPs) in Kenya to demonstrate the feasibility of the approach based on real data in sub-Saharan Africa. Currently, the daily per capita water-use in the service area of four of the five WSPs was below minimum daily requirement of 50 L/p/d. Further, non-revenue water losses were up to three times higher than the regulated benchmark (range 26–63%). Calculations showed a leakage reduction potential of up to 70% and energy savings of up to 12 MWh/a. The projected water demand is expected to increase by at least twelve times the current demand to achieve universal coverage and an average daily per capita consumption of 120 L/p/d for the urban population by 2030. Consequently, the energy input could increase almost twelve-folds with the CSI scenario or up to fifty-folds with the CSE scenario for WSPs where desalination or additional groundwater abstraction is proposed. The approach used can be applied for other WSPs which are experiencing a similar evolution of their water supply and demand drivers in sub-Saharan Africa. WSPs in the sub-region should explore aggressive strategies to jointly address persistent water losses and associated energy input. This would reduce the current water supply-demand gap and minimize the energy input that will be associated with exploring additional water sources that are typically energy intensive.