bluuebunny/crossref_metadata_2025 huggingface dataset:
Foam-mat drying technology applied for the development of cashew juice powder: effect on physicochemical properties and principal component analysis
Authors: Fernandes Janaína de Moura , Grisi Cristiani Viegas Brandão , Souza Priscila Santos , Monção Érica da Costa , Cordeiro Angela Maria Tribuzy de Magalhães , Souza Antonia Lucia de
Published: January 2025

Foam-mat drying technology has gained attention due to its ability to process sensitive fruits and produce products with desired properties while retaining their volatiles that otherwise would be lost during the drying of non-foamed materials. The objective of the study was to obtain cashew juice by drying foam-mat and evaluate the effect of adding different concentrations of ovalbumin (2%, 3% and 6%) on the physicochemical properties through the analysis of principal components. Treatments with 2% and 3% OVA showed hydrophilic characteristics that favored rehydration in aqueous mixtures. The treatment with 2% OVA showed superior results in water absorption (0.32 gH2O/g), hygroscopicity (36.52%) and lower pH (4.33). The high solubility in water (9.23%) observed in the treatment with 3% OVA. The treatment with 6% OVA showed greater oil absorption (3.23 gOil/g) characterized as more hydrophobic and can be recommended for flavoring cake mixes. Therefore, the results indicated that foam-mat drying using ovalbumin as a foaming agent has potential as a new technology to be implemented in the juice powder industry.
Influence of B4C addition on the tribological properties of bronze matrix brake pad materials
Authors: Kuş Hüsamettin
Published: January 2025

In this study, the effects of B4C particle addition on the microstructural, mechanical, and tribological properties of bronze matrix brake pad materials were analyzed. To this end, bronze matrix brake pads reinforced with different proportions (0, 3, 6, 9, and 12 wt%) of B4C particles were fabricated via hot pressing at 800°C and 40 MPa for 5 min. The hardness, density, and transverse rupture strength (TRS) were measured and friction–wear tests were performed to evaluate the effectiveness of adding B4C. The results revealed that the hardness increased with increasing B4C content, whereas the density slightly decreased. The TRSs of the B4C-reinforced specimens exceeded that of the non-reinforced material. Furthermore, the friction stability, average friction coefficient, and wear resistance, which are crucial quality parameters of the brake pad material, increased upon adding >3 wt% B4C to the specimen compared with those of the non-reinforced specimen. After the wear test, the worn surfaces of the specimens were examined via scanning electron microscopy, X-ray diffraction, and a 3D optical profilometer to identify the wear mechanisms involved during friction.
Cash Holdings in Family Firms: Outlines of an Emerging Debate
Authors: Correggi Cecilia , Cambrea Domenico Rocco , Di Toma Paolo , Ghinoi Stefano
Published: January 2025

The literature on cash holdings has gained increasing relevance within business studies, which highlights its pivotal role in determining a firm’s resource management strategy. In this study, we adopt a combination of bibliometric analysis and systematic literature review to analyse the development of literature on cash holdings and provide an overview of its theoretical and empirical evolution and identify future research paths. After collecting 46 documents from Scopus and Web of Science published from January 2011 to on 7th October 2024, we created and analysed a thematic map based on a co-word analysis to appreciate the form and content of academic discourse on the topic and investigated the content and main contributions of the 46 publications to understand the evolution of the themes discussed in the literature. Results show that family business studies are still anchored to the traditional topics of the research stream of cash holdings, such as corporate governance, and mostly employ agency theory. We found that current family business research and cash holdings only represent a first step in exploring the topic and act as forerunners for the investigation of another research stream – such as innovation/sustainability – or the employment of alternative theories – such as socioemotional wealth. Overall, we provide some insights for future research.
Wie Mütter für den Arbeitsmarkt verfügbar gemacht werden sollen
Authors: Höpfner Elena
Published: January 2025

Erziehende im Bürgergeldbezug können bis zum dritten Lebensjahr des Kindes die Forderungen, arbeiten zu müssen oder sich darauf z. B. durch Maßnahmen vorzubereiten, verneinen. Auf diesen Ausnahmetatbestand von der Pflicht zur Erwerbsarbeit – verankert im § 10 im Zweiten Sozialgesetzbuch (SGB II) – berufen sich fast ausschließlich Mütter. Diese Zeitspanne der ersten drei Lebensjahre des Kindes soll jedoch zukünftig an allen Jobcentern – so untergesetzliche Weisungen seit 2021 – intensiver als bisher dafür genutzt werden, vorhandene „Erwerbspotenziale“ der Mütter zu erkennen und ihre „Arbeitsmarktintegration vorzubereiten“. Im Rahmen dieses Beitrags bin ich der Frage nachgegangen, wie diese Bemühungen um „frühzeitige Aktivierung“ in einer Änderung der administrativen Vorgaben institutionalisiert werden. Wie sollen Mütter kleiner Kinder in der Grundsicherung zukünftig für den Arbeitsmarkt verfügbar gemacht werden und unter welchen Bedingungen kann ihnen Erwerbsarbeit zugemutet werden? Ziel des vorliegenden Beitrags ist eine Analyse dieser arbeitsmarkt- und sozialpolitisch motivierten Änderungen. Diese erfolgt mittels einer historischen Einordnung sowie einer Dokumentenanalyse der Vorgaben – die sich als Prozess der Verfügbarmachung in fünf Dimensionen aufschlüsseln und als ein Rekommodifizierungsversuch einer bisher im Wohlfahrtsstaat geschützten Lebensphase deuten lassen.
Cell adhesion molecule protocadherin-γC5 ameliorates Aβ plaque pathogenesis by modulating astrocyte function in Alzheimer’s disease
Authors: Sun Xiangyi , Pan Sili , Li Dandan , Su Min , Zheng Honghua , Zhang Yun-wu , Li Yanfang
Published: January 2025

Accumulation of astrocytes around β-amyloid (Aβ) plaques is one of the earliest neuropathological changes in Alzheimer’s disease (AD), but the underlying mechanisms and significance remain unclear. Cell adhesion molecule protocadherin-γC5 (Pcdh-γC5) has been reported to implicate in AD. Here we find elevated expression level of Pcdh-γC5 in the brain of 5×FAD mice and Aβ-treated astrocytes, and further reveal that Pcdh-γC5 deficiency leads to exacerbated Aβ deposition in 5×FAD mice. Deletion of Pcdh-γC5 impairs astrocyte migration, astrocytic response to Aβ signaling and Aβ phagocytosis in both cultured astrocytesin vitroand 5×FAD mice in vivo. Both male and female mice were used in this study. Our findings support a model in which increased expression level of Pcdh-γC5 promotes astrocyte migration in response to Aβ signaling, engulf and phagocytose neurotoxic Aβ plaques, therefore exerting a critical neuroprotective function in AD.

Significance StatementAstrocytes play a pivotal role in AD pathogenesis. Recent evidence identified Pcdh-γC5 as a potential early-stage biomarker in the CSF of AD patients. Here by usingPcdhgc5gene knockout astrocytes, we unravel the essential function of Pcdh-γC5 in promoting astrocyte migration and Aβ phagocytosis via PI3K-Akt-actin signaling pathway. By crossingPcdhgc5knockout mice and 5×FAD mice, or down regulating astrocytic Pcdh-γC5 expression with shRNA, we demonstrate the neuroprotective role of Pcdh-γC5 in ameliorating Aβ plaque pathogenesis by regulating astrocyte activity. Our investigation provides new clues in clarifying the underlying mechanisms of AD pathogenesis, especially the critical role of astrocytes in AD.
Students in the Wild
Authors: Campbell Lesley G. , Montgomery Benjamin R. , King Megan R. , Hall Jonathan , Struwe Lena
Published: January 2025

Exposure to nature can improve mental health and cognitive abilities, while creating enhanced engagement with biological course material through interactions with organisms and ecosystems. Remote biology education was suddenly implemented during the COVID-19 pandemic at many universities, and such distance education continues to provide broadened opportunities for active learning through hands-on lab and field activities. Remote science activities require explicit conversations and student training to address novel, off-campus safety issues. Here, we present inclusive approaches to safety instruction for incorporation into any biological undergraduate course. Remote lab learning not only develops students’ skills and self-efficacy in performing biology, but it also engages students in course content and stimulates their interest in observation-based research. This emphasis on safety will extend scientific practice into students’ lives while reducing risk during laboratory and field activities and afterward The safety considerations outlined here are designed to consider a global and diverse student population and will apply to a multitude of active-learning lab or field activities performed remotely by students.
The Importance of Sharing Current Scientific Information with Biology Teachers in Weekly Newsletters
Authors: Siani Merav , Levkovich Ohad , Nissan Roee Ben , Gabara Awni , Alatawna Moshera , Yarden Anat
Published: January 2025

High-school teachers and students do not usually have access to scientific research advances because original research papers contain many highly specialized words that are specific to the discipline. Scientific newsletters (SNs) summarize current scientific research advances and trends. During the 2022–2023 school year, 21 SNs teaching biology content were written by a team of science-education and biology specialists working at the National Center for High-School Biology Teachers in Israel, according to the following criteria: (a) the SNs were based on primary research papers published in international well-known scientific journals such as Nature, Cell or Science; (b) the biological content was related, albeit not necessarily directly, to the Israeli high-school biology curriculum; (c) some of the SNs were related to biological events that occurred during the week in which the SN was distributed, such as World Diabetes Day. The SNs were written in Hebrew, translated to Arabic, and sent weekly via WhatsApp to 901 high-school biology teachers. After sending 10 SNs, an anonymous questionnaire was sent to the teachers to understand their use of the SNs and identify topics to which teachers would like us to relate in the next SNs. Forty-nine teachers answered the questionnaire, revealing that according to their open-ended answers, some of the teachers valued the importance of receiving SNs teaching biology topics as a way to enrich their own biological knowledge, and to engage their students with meaningful scientific research and with the real-world work of scientists. Further research is needed to analyze the impact of the SNs on teachers’ professional development.
El baile de los que sobran. Profesión jurídica: poder político y exclusión social en Colombia
Authors: Silva García Germán , Vizcaíno Solano Angélica
Published: January 2025

Son examinados los cuestionamientos sobre la existencia de demasiados abogados y las consecuencias que pretenden derivarse: exceso de litigiosidad, problemas éticos, corrupción, uso indebido de instituciones jurídicas y consecuencias económicas nocivas. Al respecto, se rebaten las cifras de abogados y los efectos que se atribuyen a su exceso. El análisis crítico anterior lleva a probar el papel que juegan los discursos discutidos para generar una mayor exclusión social. Establecido esto, el estudio procura develar las distintas aristas que exponen la desigualdad y la exclusión social para la profesión de abogado.
Más allá del binarismo: el dilema ético de la inclusión de género en las fuerzas armadas estatales
Authors: Tirado Acero Misael , Quintero Sierra Olga Lucía
Published: January 2025

El presente artículo busca mostrar cómo históricamente las concepciones binarias de género se han constituido en las pautas de valor predominantes en los procesos y políticas de inclusión en las instituciones armadas estatales, dejando poco o nulo margen de reconocimiento de otras identidades diversas no correspondientes a las categorías hombre y mujer. De esta manera, pese a evocar la denotada inclusión, el desconocimiento de las personas autorreconocidas como no binarias se evidencia ya desde las mismas tipificaciones sociales y se consolidan en posibilidades aún existentes de negación de quienes no encajan en el binarismo y a quienes se les busca encasillar en las nociones de lo aceptado y lo rechazado culturalmente como comportamiento válido de hombres y mujeres que portan los uniformes de las instituciones castrenses, siendo esto una vía directa a la negación de derechos en condiciones de igualdad al tiempo que negación a la diversidad de identidades de ser.
Bayesian Hierarchical Modeling of Spatiotemporal Data
Authors: Sosa Juan
Published: January 2025

In this paper, we illustrate in-depth Bayesian hierarchical statistical modeling approaches. Bayesian hierarchical modeling provides a robust framework for analyzing spatial data, accommodating complex dependencies, making possible incorporating external knowledge into the analysis. To do so, we consider a dataset from 80 stations in the Venezuelan state of Guárico consisting of accumulated monthly rainfall in a time span of 16 years. The spatial correlation is modeled by using a Mat´ern correlation function with a fixed smoothness parameter. Following Banerjee et al. (2014), we examine two fully Bayesian parametric approaches: One of them static, based on a hierarchical model with latent variables; and the other spatiotemporal, based on the dynamic framework given in West and Harrison (2006). Both alternatives are sensible ones, but due to the nature of the data, the dynamic model is more appealing since it gives a complete spatiotemporal characterization of the response variable.
Análisis factorial en la caracterización de las variables generadoras de estrés académico en estudiantes universitarios de nivelación
Authors: Chacón Contreras Ana
Published: January 2025

The academic stress is, by definition, a reaction of emotional activation, physiological,of knowledge and behavior in the presence of stimulus and academic events.This degree investigative work pretends to offer the characteristics of the academicstressors factors from the students of El Chimborazo National University unit ofAdmission and Standardization, rising from the factorial analysis. The investigationsgeneral objective was to determinate the relationship between the academicsstressors scale factors and the student´s social demographics variables. The researchingwork focusses are descriptive, transverse in the view from a quantitative perspective, making use of dialectic contradictions scientific methods, expert´smethods, mathematic statistics, checking and analysis of bibliographic synthesismethods. On the factorial stage it was watched that those variables that generateacademic stress are put in order of two groups; the one, those related to theteacher (factor 1), such as methodology deficiency, tests and public interventions.Another, by the student´s dimensions (factor 2), such like the contents value lacking, participation difficulties, negative social environment, yield lacking, overload.We watch that while is older age a student, increases the academic stress becauseof factor 1, as well as female students, married ones, separated, illiterate or justwith first learning level, and the lack of internet, computer, cell phone and printer
Production of hydroxyapatite from phosphoric rock
Authors: Soto-Calle Gloria , Gómez- Zapata Adrián , Rojas-Reyes Néstor , Díaz-Bello Sandra
Published: January 2025

The article focuses on processes used to obtain hydroxyapatite from phosphate rock in the municipality of Pesca (Department of Boyacá, Colombia) by leaching with nitric acid. An analysis was carried out to evaluate the influence of different concentrations of leaching acid and treatment time on the recovery of phosphorus and calcium ions. The results indicated that maximum recovery of phosphorus and calcium ions was achieved by increasing concentration to 5M. The influence of the concentration of the precipitating agent was also analyzed and it was found that, although increased concentrations improve the pH adjustment rate, the purity of the HAp obtained decreases at higher concentrations, possibly due to the formation of other species associated with sodium hydroxide. Following washing with deionized water, pure HAp was obtained as a final product, which was characterized using XPR, XRD, SEM/EDS and FTIR.
Colombian monthly energy inflows predictability
Authors: Hurtado-Montoya Andrés Felipe , Moreno-Reyes Nicolás Alberto
Published: January 2025

Streamflow forecasting is essential for water resources management in several social and economic strategic sectors, involving space-temporal variability modeling of the hydrological processes and the influence of several climatic phenomena. Furthermore, high water-dependent sectors such as the Colombian electricity market, require not only the expected streamflow values but also the occurrence probability or reliability bands of such forecast inflows necessary in robust risk analyses. We propose a mathematical approach for monthly streamflow forecasting in Colombia and quantify its predictability, incorporating climate model outcomes as a time series of macroclimatic indexes and punctual hydro-climatological stations. The methodology integrates parametric and non-parametric models, exogenous variables analysis, and uncertainty estimation through stochastic modeling. This research will contribute to the Colombian hydrology understanding and provide elements for risk analysis, planning, and decision-making in social and economic sectors involved with water resources management.
Virtual tool of nonlinear model of interconnected tanks with PID control implementation using EJsS
Authors: Rodríguez-Diaz Oscar Oswaldo , Sierra-Herrera Oscar Humberto , González-Niño Mario Eduardo
Published: January 2025

This paper describes the development and implementation of a virtual tool (TANQUES EN SERIE PID) of a system of two interconnected tanks made in Easy Java/JavaScript Simulations (EJS,), a tool that seeks to motivate learning control concepts in engineering programs. The simulated model corresponds to the non-linear system of interconnected tanks, which presents graphically the behavior of tank levels on an open loop, this application allows varying physical input parameters of the process, as the cross section of the tanks, resistivity constants of the valves and the input flow of process. The system is also presented in closed loop, presenting the behavior when a PID controller is implemented to the process, controller and time constants can be modified to enter a disturbance to the model and by doing this we are verifying the time response and system reaction when subjected to a perturbation. The tool is verified comparing the results using Simulink and equilibrium equations.
Relationship between climate variability and mass removal processes. Tunja-Páez case study
Authors: Rojas-Mesa July Katerine , Leguizamón-Barreto Luis Carlos , Vega-Báez Luis Alfredo
Published: January 2025

This article focused on the relationship between the influence of climatic variables and seismic activity in the dynamics of slopes that presented mass removal phenomena in the case study: Tunja-Páez Corridor. This analysis was carried out through the application of a probabilistic model that integrated parameters of soil resistance, seismic activity, and accumulated precipitation to establish the definition of rainfall thresholds obtained from the rainfall records preceding each of the removal events. This model used first order, second moment FOSM, and the Poisson distribution of probabilistic foundations to estimate the probability of failure of given slope. Additionally, the change in precipitation in the years 2040, 2070, and 2100 as defined by forecasts of Climate Change (CC) according to IDEAM were used to compare the effects on the probability of soil saturation.
Numerical simulation of CBR test and HS-Small parameter characterization for Bogotá soils
Authors: Herrera-Cano Camilo Ernesto , Ruge-Cárdenas Juan Carlos , Bastidas-Martínez Juan Gabriel
Published: January 2025

This paper presents the determination of HS-Small constitutive model parameters for the Sabana Formation, the major deposit of Bogotá city. Mechanical parameters were obtained from index parameter of physical characterization, using correlations consulted as state-of-the-art. The characterization obtained has been validated with a numerical model of the CBR test, showing good agreement with typical values in the City of Bogotá. The methodology presented here would make possible the determination of the HS-Small parameters for the entire profile of the Sabana Formation. Once the parameter sets of the samples have been validated, a parametric analysis is performed, varying the friction angle and the shear module values. This parametric study shows that for the HS Small constitutive model, the stiffness modulus has a greater contribution in the CBR test than the friction angle, which would support the correlations between the resilient modulus and the CBR value; correlations widely used in pavement engineering. The methodology of characterization presented here would make possible the determination of the HS-Small parameters for the entire profile of the Sabana Formation. This allows for the numerical simulation of complex geotechnical works in the early stages of design when advanced mechanical laboratory tests are not available.
Use of end-of-life tires for the production of a waterproofing agent as a strategy to promote the circular economy
Authors: Salcedo-Mojica Valentina , Arturo-Calvache Jaime , Ramírez-Meneses Cristina
Published: January 2025

This paper develops a formulation to produce a laboratory-scale waterproofing for exterior walls and roofs using recycled tires. It begins by identifying its chemical composition using Fourier transform infrared spectroscopy and selects a technology using the ELECTRE method. It uses a reticular simplex mixing design of experiments to adjust the resin proportions according to their mechanical properties. In addition, it evaluates the critical pigment volume content and parameters such as water absorption, permeability, total solids content and mechanical properties for quality assurance. Acrylic emulsions were found to be favorable in cost, application, safety, and efficiency; the flexible resin offers better elongation and the rigid one better tensile strength, with less than 10% tire reducing porosity. The results support the competitiveness of the product and confirm the effective use of recycled tires in waterproofing, offering a favorable and functional approach to construction.
EDITORIAL
Authors: Portugueis Diane
Published: January 2025

A presente edição traz como primeiro texto um pertinente debate acerca da experiência clínica, intitulado: “A clínica psicanalítica na prevenção e tratamento de casos limítrofes na infância”, das autoras Marina Oliveira Lopes, Priscilla Alves Fernandes dos Santos e Thalita Lacerda Nobre. O texto aborda casos limítrofes e compreende como a intervenção psicológica pode minimizar os sinais aparentes em crianças até o período da latência, partindo do referencial psicanalítico.
A constituição psíquica é abordada desde o início da infância para então serem discutidos os principais pontos de ancoragem e destinos psíquicos que levam a esse modo de estruturação psíquica. “Nesta pesquisa, pretendeu-se analisar alguns casos e elucidar as potencialidades de atuação do psicólogo. Tratando de um caráter preventivo, julgou-se necessário abordar o desenvolvimento infantil, entendendo que a personalidade se constituirá, gradativamente, nas primeiras duas décadas de vida. Dessa forma, torna-se um período promissor na possibilidade de intervenção, uma vez que a personalidade não está plenamente constituída e as limitações não se estabeleceram, como esperado, na fase adulta (...) busca-se ampliar o conhecimento acadêmico sobre a técnica psicanalítica, promovendo uma reflexão para o desafio da clínica dos casos limítrofes, enfatizando a prevenção destes”. Nos convocam à leitura as autoras.
Milicianos y chichimecos en tiempos de reformas: Sierra Gorda al finalizar el siglo XVIII
Authors: Ramírez Casas Ulises
Published: January 2025

El presente artículo muestra un análisis en torno a las reacciones que algunas autoridades locales en Sierra Gorda tuvieron ante los cambios derivados de las reformas llevadas a cabo al final del siglo XVIII. A través del estudio de un conjunto de fuentes se analizan los discursos sobre los indios con la intención observar su utilización y reinvención para posibilitar el mantenimiento de cargos frente a las reformas militares implementadas al final de dicho siglo. Las conclusiones muestran que las autoridades militares locales echaron mano del discurso de la frontera de guerra para justificar la presencia de las compañías milicianas.
El equilibrio imposible: Formas de resistencia a la implementación del sistema de Intendencias en el Valle de Guatemala
Authors: Parrilla Albuerne Ana María
Published: January 2025

En la Audiencia de Guatemala los representantes de las diferentes instituciones con sede en la cabecera -como lo fue el cabildo, la audiencia o la real hacienda-, aplicaron diferentes estrategias para evitar o retrasar la instauración de la Ordenanza de Intendentes en el territorio adyacente a la capital; es decir, en el Valle de Guatemala. Estas tácticas se pueden considerar formas de resistencia al cambio institucional por varios factores: el aseguramiento de la continuidad de un orden establecido -la necesidad de una seguridad-, la falta de claridad sobre las ventajas de aplicar este nuevo sistema y que los miembros de la élite percibieron que con la aplicación del sistema de intendencias sus intereses podrían ser amenazados. De estas formas, en este trabajo pretendemos desgranar la actuación de los representantes de dichas instituciones y la forma en que implementaron una oposición silenciosa al cambio.
A fin de preservar del contagio del fanatismo a las religiosas…” La acción pastoral del obispo de Guadalajara, Diego Rodríguez de Rivas ante el extrañamiento de los Jesuitas. 1767 – 1768
Authors: Gutiérrez Lorenzo María Pilar , Hernández Víctor David
Published: January 2025

Este artículo analiza la labor realizada por el obispo de Guadalajara, Diego Rodríguez de Rivas, para frenar los brotes de resistencia en la capital de Nueva Galicia durante y después de la expulsión de los jesuitas. Para ello, abordamos las resistencias surgidas en la Nueva España y la importancia de las cartas pastorales en el caso de Guadalajara. Nuestra hipótesis es que la labor pastoral realizada por el Obispo de Guadalajara en esta ciudad demuestra que, si bien hubo resistencia en la capital de Nueva Galicia, esta se manifestó de manera no violenta.
Perfil epidemiológico de pessoas com alergia alimentar atendidas em um hospital universitário
Authors: Vital de Oliveira Vinícius , Abdias Varjão Stephany , Figuerêdo Moreira Iramirton
Published: January 2025

Justificativa e Objetivos: a alergia alimentar é uma doença que apresenta resposta imunológica anormal após contato com determinado alimento. Representa um transtorno significativo, pois envolve restrições alimentares, sociais e psicológicas. Assim, este trabalho tem como objetivo descrever o perfil epidemiológico das pessoas atendidas no ambulatório de alergia e imunologia clínica de um hospital universitário em Maceió, Alagoas. Métodos: trata-se de estudo descritivo e quantitativo, a partir da análise de prontuários de pacientes com alergia alimentar atendidos no Ambulatório de Alergia e Imunologia Clínica do Hospital Universitário Professor Alberto Antunes, no período de outubro de 2016 a outubro de 2023. Resultados: dos 678 pacientes, 233 foram incluídos, com prevalência de mulheres (61,8%) e idade média de 21,8 anos. Os alérgenos predominantes foram frutos do mar (25,9%), proteína do leite de vaca (24,2%), ovo (10,3%), frutas (9,3%), leite (7,6%), grãos (5,8%), peixes (4,1%), carnes (4,1%), chocolate (2,0%) e vegetais (1,0%).Conclusão: a população estudada nesta pesquisa apresenta um perfil epidemiológico semelhante aos dados da literatura, e evidencia características que justificam a necessidade de maior atenção quanto ao diagnóstico e tratamento precoce, visto que houve uma prevalência do acometimento da faixa etária de adultos-jovens que são economicamente ativos, além da presença significativa de alimentos comuns no cardápio da população brasileira. Ademais, o diagnóstico da alergia alimentar é compartilhado com outras doenças imunoalérgicas, o que torna essencial o incentivo de estudos que analisem a relação fisiopatológica entre essas.
Fatores demográficos e clínicos associados às infecções hospitalares em crianças e adolescentes vítimas de queimaduras
Authors: Pimenta Susany Franciely , Flauzino Zampar Elisângela , Contiero Ana Paula , Meneguetti Pieri Flávia , Dario Capobiango Jaqueline , Aparecida Pimenta Rosângela
Published: January 2025

Justificativa e Objetivos: as queimaduras são uma das principais causas de acidentes domésticos e a terceira principal causa de mortalidade em crianças e adolescentes menores de 14 anos. O objetivo deste estudo é identificar os fatores demográficos e clínicos associados às infecções relacionadas à assistência à saúde (IRAS) em vítimas de queimaduras menores de 18 anos atendidas no Centro de Tratamento de Queimados (CTQ). Métodos: estudo transversal analítico, realizado no CTQ de um hospital público, utilizando fichas de notificação de IRAS e prontuários de pacientes menores de 18 anos hospitalizados de 2009 a 2019. As variáveis demográficas consideradas foram sexo e idade, enquanto as variáveis clínicas incluíram agente causal, superfície corporal queimada (SCQ), profundidade da queimadura, tempo e local de hospitalização, datas de admissão e de detecção da infecção, diagnóstico de IRAS, procedimentos invasivos e cirúrgicos, sítio da infecção, agente etiológico, perfil de sensibilidade aos antimicrobianos, antimicrobianos utilizados no tratamento das infecções, diagnóstico de sepse e choque séptico, além do desfecho clínico. Foram utilizadas frequências absolutas e relativas, e o teste qui-quadrado foi usado para variáveis categóricas. A análise multivariada foi conduzida por regressão de Poisson com ajuste de variância robusta. Resultados: entre as 591 vítimas, 187 (31,6%) desenvolveram IRAS. As IRAS foram associadas a maior SCQ, queimaduras de 3° grau, maior tempo de hospitalização e óbito. Fatores associados às IRAS incluíram área queimada ≥21%, tempo de hospitalização ≥15 dias e óbito. Microrganismos prevalentes foram Acinetobacter baumannii multirresistente (MR) e Pseudomonas aeruginosa MR. Conclusão: crianças com queimaduras graves e prolongada hospitalização apresentaram maior vulnerabilidade às IRAS e óbitos associados.
Abordagem de controle antimicrobiano em múltiplas etapas em uma unidade de terapia intensiva neonatal: um estudo quase experimental
Authors: Alves Farias-Filho Francisco , Vieira Souza Philipe , Nunes da Rocha Nascimento Susana , De Carvalho Rodrigues Rafaela , Martins Gonzaga do Nascimento Mariana , De Frias Carvalho Vinicius
Published: January 2025

Justificativa e objetivos: A resistência antimicrobiana é considerada um dos maiores desafios globais de saúde do século XXI. Os antimicrobianos são os medicamentos mais utilizados nas Unidades de Terapia Intensiva Neonatal e seu uso indevido e excessivo facilita a seleção de infecções causadas por organismos multirresistentes e aumenta o risco de efeitos adversos. Nesse contexto, o objetivo deste estudo foi avaliar a eficácia de uma abordagem de gestão antimicrobiana em múltiplas etapas em uma Unidade de Terapia Intensiva Neonatal. Métodos: Este estudo longitudinal quase experimental usou um desenho de pré-teste/pós-teste para avaliar a implementação de intervenções de gestão antimicrobiana realizadas em 4 etapas. Na etapa I, foi mapeado o perfil dos recém-nascidos. Na Etapa II, foram desenvolvidos protocolos farmacoterapêuticos para medicamentos parenterais. Na Etapa III, foi implementado o gerenciamento de medicamento parenteral para a Unidade de Tratamento Intensivo Neonatal. Etapa IV, uma calculadora eletrônica de dosagem foi integrada ao sistema informatizado de prescrição médica. Na Etapa V, médicos e profissionais responsáveis pela dispensação de medicamentos foram treinados por farmacêuticos clínicos. A efetividade foi avaliada comparando a incidência de erros de prescrição antes e depois da implementação. Resultados: Houve 513 prescrições durante o período de implantação, sendo 332 de vancomicina, 149 de cefepima e 42 de piperacilina-tazobactam. Foi observada uma redução estatisticamente significativa na incidência de erros de prescrição envolvendo dose e tempo de infusão. Conclusão: A implementação de múltiplas intervenções de gestão antimicrobiana baseadas em farmácias resultou numa melhoria no perfil de segurança das prescrições antimicrobianas.
Rede Brasileira de Pesquisas em Tuberculose (REDE-TB): missão de desenvolvimento científico para eliminar a tuberculose
Authors: Rosa Rander Junior , Marques Valença Ana Beatriz , Perticarrara Ferezin Letícia , Martins Ribeiro Natacha , De Abreu Paula Daniella , Laine de Paula Andrade Rubia , Bueno Bernardi Willie Otávio , Mendes da Silva Diogo Henrique , Aparecida Monroe Aline , Chimara Silva Erica , Silva Araújo Vânia Maria , Calçada Carvalho Anna Cristina , Leonor Noia Maciel Ethel , Junqueira-Kipnis Ana Paula , Lapa e Silva Jose Roberto , Gonçalves Possuelo Lia , Arcêncio Ricardo Alexandre
Published: January 2025

Justificativa e Objetivos: Desde seu lançamento, a Rede Brasileira de Pesquisas em Tuberculose (REDE-TB) tem contribuído significativamente para a produção científico-tecnológica no Brasil. Este estudo teve como objetivo buscar essa contribuição nas áreas estratégicas de prevenção, diagnóstico e tratamento da tuberculose, relevantes para o cumprimento da Agenda 2030 para o Fim da Tuberculose. Métodos: A pesquisa foi baseada em um levantamento nas bases de dados Lilacs e Embase/MEDLINE, focando em estudos primários e secundários sobre tuberculose publicados entre 2018 e 2023 vinculados à REDE-TB. Foram extraídos dados de identificação, abrangência, local de estudo, delineamento, área e população estudada. A análise utilizou estatística descritiva e georreferenciamento. Resultados:Identificou-se 670 publicações, com 447 incluídas na revisão. Dentre estas, 315 (70,5%) foram publicadas em periódicos internacionais. A maioria dos estudos no Brasil ocorreu no Rio de Janeiro (29,0%), seguido por São Paulo (19,2%), Rio Grande do Sul (13,8%), Paraná (11,6%) e Amazonas (10,7%). Após o Brasil, 24 (8,0%) estudos foram realizados na Índia, seguidos pela África do Sul (16 - 5,3%) e Uganda (10 - 3,3%). Os estudos apresentaram delineamentos variados, incluindo revisões de literatura e estudos epidemiológicos, com foco principal em tuberculose doença (56,4%) e, em menor proporção, em tuberculose infecção (12,6%). Conclusão: O estudo evidencia a importância da Rede Brasileira de Pesquisas em Tuberculose (REDE-TB) na produção científica e tecnológica sobre TB, contribuindo no desenvolvimento de estratégias de enfrentamento à doença no Brasil e no mundo.
Language conundrum in higher education institutions in South Africa: One step forward or two steps back?
Authors: Munyai Dr Anzanilufuno
Published: January 2025

Over the years, South African Courts have adjudicated on the status of English and Afrikaans in language policies of higher education institutions. This article reflects on the slow efforts by the South African government and higher education institutions towards the development and inclusion of languages indigenous to South Africa. Taking a textual analysis approach, the aim of this paper is to place emphasis on the need to develop and include indigenous languages of South Africa in the language policies of higher education institutions. The paper further seeks to contend that the inclusion of languages indigenous to South Africa will facilitate social cohesion and affirm restorative justice efforts given the historical marginalisation of black people in language and education. Building on a previously co-authored article addressing the use of indigenous languages in higher education institutions, this paper is limited to Chairperson of the Council of UNISA v AfriForum NPC 2021, the 2022 Commission of inquiry into allegations of racism at Stellenbosch university also known as the Kampepe Report, and the 2023 South African Human Rights Commission's Investigative Report into Allegations of Unconstitutional Language Practices at Certain Stellenbosch University Residences. The analysis presented in this paper will be grounded in transformative justice and a transitional justice framework.
A framework for creating and analysing wordless picturebooks
Authors: van Os Maria , Haese Adrie , Pretorius Deirdre
Published: January 2025

Wordless picturebooks are texts that convey a narrative through a series of images with little or no written information and have gained popularity among academics, readers, and illustrators. These books have evolved from purely educational tools to complex and experimental works, attracting prominent artists and addressing challenging themes. Described as "crossover", wordless picturebooks frequently defy traditional age, addressing and attracting readers of all ages.
While research on wordless picturebooks is growing, literature generally focuses on wordless picturebooks as educational tools for a younger readership and the aesthetic qualities of the finished picturebook - rarely examining the complex process of creating a wordless, visual narrative. In this article we reflect on the creation of a wordless crossover picturebook to gain insight into this process from Maria van Os's perspective as a practising illustrator and illustration lecturer. The practice-based approach sheds light on the wordless crossover picturebook as an artefact and the process undertaken by an author-illustrator when creating a wordless narrative. A framework for creating wordless narratives was conceptualised by distilling the findings from the practice and framing them within narrative theory. The framework is intended to aid students, lecturers, and practitioners in creating and analysing wordless picturebooks.
Pathology and visual culture: The scientific artworks of Dr. Jean-Martin Charcot and the Salpêtrière School
Authors: du Plessis Rory
Published: January 2025

In art historical investigations of Dr Jean-Martin Charcot and his work at the Salpêtrière, the focus has largely been on the representation of hysteria. Seminal texts have pioneered investigations in this field, and many students in art history are as acquainted with the key debates of photography and hysteria as they are with studying the Old Masters. Natasha Ruiz-Gómez's book breaks new ground by turning much of her attention away from the representation of hysteria, to explore the 'pathological drawings, photographs, casts, and sculptures' (4) of neurological diseases that the clinicians and artists of the Salpêtrière created. Pathology and Visual Culture offers a case study of how these scientific artworks 'combined scientific knowledge and artistic expression' (4). Ruiz-Gómez presents a commendable study, situated within the fields of art history and visual culture, on how the scientific artworks trouble the binary between science and art, objectivity and aesthetic, and forwards an interpretation of the artworks that considers how the c
How Jacaranda rain - a South African story was written
Authors: Hettema Joan
Published: January 2025

Hettema, Joan, 2019
Self-published, Pretoria, ISBN-13: 9781980735885, ISBN-10: 1980735883

This is an account of how I went about writing my book of memoirs Jacaranda rain - a South African story. Several things immediately spring to mind when asked, 'How did you go about writing this book'? Foremost is the fact that every person who picks up a pen, stylus, writing implement, or lays their hands on a typewriter or computer no doubt has a different and personal reason, aim, or motive for doing so.

What is it that induces that irresistible feeling that drags at one's gut, nagging one to produce the words that hopefully reflect what we want to express? Is it because we are trying to restore order to the chaos of life around us?

In my case, since I can remember, words have held a magical fasciation ... long before I learnt to read, words held me spellbound as my father read me fairy tales. My father even nicknamed me 'Rumpelstiltchen' as I would chant the word and dance around an imaginary fire for some time after the story had ended.
Between memory & fantasy: Autofiction & worldbuilding in autobiographical comics
Authors: Roodt Octavia , Fossey Natalie
Published: January 2025

This article locates the practice of creating autobiographical comics (autobiocomics) as products of autobiographical fiction (autofiction) and imaginary worlds. Autobiocomics is a comics genre characterised by imaginative and subjective representations of the autobiographical self. Autobiocomic stories attempt to convey an emotional truth by depicting the author's authentic reactions to people, places, or events. With this research, we intend to contribute to the existing autobiocomic scholarship by demonstrating that autofiction and worldbuilding theories can deepen the analysis of specific autobiocomics when instrumentalised in tandem. This provides the opportunity to read autobiocomic texts for their shared characteristics and generate insights on the author's relationship to their representations of self and the textual world wherein the self is revealed. In this article, we review autobiocomics, providing a brief chronological overview and identifying relevant concepts to position the analysis and discussion thereafter. The analysis suggests future research into the implications of the authors' embodiment of their textual avatar and how they inhabit the textual world. Three autobiocomics are read, discussed, and analysed to demonstrate the characteristics of the medium as it pertains to both these theories: Drieman (2020) by Wide Vercnocke, La mer à boire (2022) by Blutch, and Fluctuat et Mergitur (2020) by Conrad Botes.
A possible drug interaction between sodium valproate and clonazepam resulting in severe drowsiness and limb weakness：A case report and literature review
Authors: Meng Xiaotong , Wang Bo , Deng Manqing
Published: January 2025

The treatment process of an 11-year-old girl diagnosed with Angelman syndrome, who experienced severe drowsiness and limb weakness following the combination of sodium valproate and clonazepam, is analyzed herein. Initially, the patient was prescribed levetiracetam, clobazam, clonazepam, and sodium valproate. However, she subsequently developed significant lethargy and weakness in her limbs. Upon her admission, the clinical pharmacist take medication reconciliation the following day, identifying clonazepam as a highly relevant factor in her condition. The medical team collaboratively adjusted the inappropriate medications. Ultimately, the patient's symptoms improved, leading to her discharge.
Aberrant Immunohistochemical stains among 573 cases of Diffuse Mesothelioma
Authors: Zhu Min , Zhang David
Published: January 2025

Background: Diagnosis of malignant mesothelioma often requires differentiating it from other metastatic malignancies including breast cancer, lung cancer, ovarian cancer, colorectal cancer, etc. Immunohistochemical stains (IHC) are important means to assist in confirming mesothelioma and ruling out metastatic cancers. Although mesothelial specific markers have been used for diagnosis, aberrant immunostains were also observed in clinical practice which often confounded the diagnosis. In this study, we analyzed the positive rate of commonly used IHC markers in the diagnosis of mesothelioma among 573 patients.
Design: 427 cases of epithelioid mesothelioma, 87 cases of biphasic mesothelioma and 59 cases with sarcomatoid mesothelioma were retrieved from the pathology consultation files between 2020-2023. The positive rates of over 50 IHC markers including over 30 aberrant IHC markers were analyzed.
Results: The positive rates of mesothelial markers, such as calretinin, WT-1 and D2-40, and epithelial markers, such as cytokeratins, were highest in epithelioid type, intermediate in biphasic type and lowest in sarcomatoid type mesothelioma. The mesenchymal marker vimentin and additional marker GATA-3 were highly expressed in sarcomatoid mesothelioma. The highest loss rate of BAP-1 was in epithelioid type, while the highest loss rate of MTAP was in sarcomatoid type. The CDKN2A (p16) deletion was observed equally in both epithelioid and sarcomatoid/biphasic types. Over 30 aberrant markers were observed. For epithelioid type, commonly observed aberrant IHC markers included MOC-31, BerEP4, PAX-8, p63, CK20, NKX3.1 and ER. For biphasic type, significant aberrant IHC markers included MOC-31, Ber-EP4, PAX8, CK20 and p40. For sarcomatoid type, notable aberrant IHC markers included p63, SMA, ERG and CD31. Among these aberrant IHC markers, MOC-31, Ber-EP4 and p63 were more commonly observed in pleural epithelioid mesothelioma, whereas PAX-8 in peritoneal epithelioid mesothelioma.
Conclusions: Our data demonstrated that aberrant immunostains were common in all of the histological types of mesothelioma. Therefore, the diagnosis of mesothelioma should be based on correlation of clinical presentation, radiological findings, and selective panel of immunostains, and should not be distracted by aberrant immunostains.
Internal Re-keying Based Modified AES
Authors:   Ph.D. Student, Gujarat Technological University, Ahmedabad, Gujarat, India, Rathod Amit , Patel Kajal
Published: January 2025

Objectives: Masking and re-keying are two major countermeasures against the Power Side Channel Analysis attacks. Re-keying has either secret sharing overhead or needs to be used in synchronization. The Advanced Encryption System (AES) has been modified in the proposed scheme and uses re-keying without the need for secret random sharing or need for synchronized communication. The research proposed a modified AES scheme and validated its effectiveness with the AES. Methods: This study proposes modifying AES and then implementing it as software encryption using Python. As the AES has been modified, the proposed scheme should also match its strength to be further used against the Power Analysis Attack. Avalanche parameter is used to check the proposed solution strength. A data set of 10000, 50000, and 100000 records were generated to test the avalanche effect. The avalanche of existing AES and modified AES are then compared. Findings: The results indicate that the avalanche effect for both AES and the modified AES remains equivalent for the supplied dataset. To analyze further, the avalanche distribution is analyzed and randomness is checked using the Shannon entropy and found that the modified AES provides 0.5% more randomness against the AES. Hence, the modified AES fulfills the benchmark criteria to further check its strength against the Power Side Channel Analysis attacks. Novelty: The algorithm uses a part of the plain text to generate the round key making the resultant key unique and as it can be re-generated from the ciphertext and original key schedule on the decryption side, the random sharing is not needed.

Keywords: Masking, Random Sharing Overhead, Differential Power Analysis (DPA), AES, Avalanche Effect, Re-keying