bluuebunny/crossref_metadata_2025 huggingface dataset:
SUPERVISOR KEPALA SEKOLAH DALAM MEWUJUDKAN PARTISIPASI GURU PPKn DI SMP NEGERI 2 KOTA TERNATE
Authors: Leko Tati , Kamisi Mohtar , Abbas Irwan
Published: January 2024

Tujuan penelitian yang hendak dicapai yaitu: (1) untuk mengetahui kepala sekolah sebagai supervisor dalam mewujudkan partisipasi guru PPKn dan peserta didik di SMP Negeri 2 Kota Ternate, (2) untuk mengetahui Faktor-faktor apa saja yang mendukung dan menghambat kepala sekolah dalam mewujudkan partisipasi guru PPKn di SMP Negeri 2 Kota Ternate. Metode yang digunakan dalam penelitian ini adalah metode penelitian deskriptif kualitatif. Sumber data dalam penelitian ini adalah kepala sekolah dan guru mata pelajaran PPKn di SMP Negeri 2 Kota Ternate. Teknik analisis yang digunakan dalam penelitian ini adalah menggunakan metode analisis kualitatif. Berdasarkan analisis data dan kesimpulan dapat diketahui (1) pelaksanaan supervisi kepala sekolah di SMP Negeri 2 Kota Ternate tergolong sangat baik, karena dalam pelaksanaan supervisi kepala sekolah yang pertama beliau lakukan yaitu menyusun suatu perencanaan tentang langkah-langkah yang harus dilakukan dalam mensupervisi, kedua melakukan pengawasan kelas pada saat proses pembelajaran berlangsung, ketiga melakukan analisis perkiraan mengenai apa yang harus diperbaiki. Selain itu kepala sekolah melakukan pelaksanaan supervisi setiap awal semester. Peran kepala sekolah sebagai supervisor dalam mewujudkan partisipasi guru PPKn di SMP Negeri 2 Kota Ternate yang pertama, kepala sekolah berperan sebagai motivator yaitu mampu memberikan motivasi berupa arahan-arahan kepada guru-guru sehingga menciptakan pendidik yang profesional. Kemudian sebagai fasilitator yaitu kepala sekolah mampu menyediakan fasilitas yang akan mempermudah kegiatan belajar mengajar sehingga menciptakan lingkungan belajar yang menyenangkan, (2) faktor pendukung kepala sekolah dalam meningkatkan partisipasi guru di SMP Negeri 2 Kota Ternate adalah terciptanya suasana kondusif dan rasa aman di sekolah, komunikasi yang terjalin baik antar warga sekolah, serta adanya pemberian reward untuk guru yang berprestasi dan juga bisa sebagai motivasi untuk guru yang lain. Adanya suatu penghargaan yang diberikan kepala sekolah akan 176 mempengaruhi semangat kerja guru agar lebih giat dan mempertahankan kinerja yang baik. Sedangkan faktor penghambat kepala sekolah dalam mewujudkan partisipasi guru adalah adanya guru yang memiliki karakter yang kurang bersosialisasi, merasa minder, kurang motivasi, dan kurang disiplin;
PERAN GURU PPKn DALAM MEMBUDAYAKAN GERAKAN LITERASI SEKOLAH PADA PESERTA DIDIK DI SMPE NEGERI 2 KOTA TERNATE (STUDI KASUS DI KELAS VIII)
Authors: Usia Tri Enadha R , Hasmawati Hasmawati , Sergie Misrina
Published: January 2024

Penelitian ini dilatarbelakangi oleh kurangnnya minat baca peserta didik dan kesadaran akan pentingnya literasi serta berliterasi hanya karena diminta atau diperintahkan oleh guru.Tujuan dari penelitian ini adalah 1) Mengetahui peran instruktur PKn dalam pembinaan gerakan literasi pada siswa SMP Negeri 2 Kota Ternate, 2) variabel-variabel yang membantu dan menghambat gerakan tersebut. Penelitian ini merupakan penelitian deskriptif kualitatif dengan menggunakan metode studi kasus dan yang menjadi subjek peneltian yaitu Kepala sekolah, Wakasek Kesiswaan, Guru PPKn Kelas VIII dan peserta didik kelas VIII. Teknik pengumpulan data yang digunakan adalah observasi, wawancara dan dokumentasi. Teknik analisis data menggunakan reduksi data, penyajian data dan penarikan kesimpulan/verifikasi. Hasil penelitian ini menunjukkan bahwa (1) guru PPKn selalu memberikan dorongan yang tegas kepada peserta didik untuk berliterasi, meminta peserta didik untuk membaca dan membuat ringkasan dengan melakukan pembiasaan-pembiasaan literasi 15 di kelas pada setiap mata pelajaran (literasi terbimbing), meminta peserta didik untuk membaca telebih dahulu di rumah sebelum ke sekolah (literasi kultural), Menganjurkan peserta didik untuk memanfaatkan waktu luangnya agar selalu berada di kelas untuk membaca (continuitas literasi), maupun di area-area baca yang sudah disediakan oleh pihak sekolah. (2) Terdapat faktor pendukung dan penghambat Gerakan Literasi Sekolah pada peserta didik SMP Negeri 2 Kota Ternate, yang menjadi faktor pendukung yaitu, fasilitas-fasilitas untuk literasi telah tersedia, dalam pelaksanaan literasi sudah dilakukan guru melalui pembiasaan literasi baca dan tulis pada peserta didik, adanya buku-buku di setiap sudut baca dalam ruang kelas dan di perpustakaan. Sedangkan yang menjadi faktor penghambat adalah kurangnya motivasi peserta didik untuk berliterasi dan hanya berliterasi ketika diperintahkan oleh guru, serta terdapat salah satu area literasi yang sudah jarang digunakan
PELESTARIAN TRADISI LISAN DOLA BOLOLO OLEH MASYARAKAT KECAMATAN PULAU HIRI (STUDI KASUS DI SOA DORARI ISA
Authors: Wahab Irfan , Muhammad Syahri , Yusuf Mukhtar
Published: January 2024

Pokok permasalahan penelitian ini adalah tergerusnya tradisi lisan Dola Bololo yang menjadi ciri khas nilai kehidupan sosial masyarakat Hiri, terutama di Soa Dorari Isa. Rumusan masalah adalah (1) Bagaimana pelestarian tradisi lisan Dola Bololo oleh masyarakat Kecamatan Pulau Hiri, (2) Apa saja nilai dan pesan moral yang terkandung dalam tradisi lisan Dola Bololomasyarakat Kecamatan Pulau Hiri, dan (3) Apa saja faktor pendukung dan penghambat pelestarian tradisi lisan Dola Bololomasyarakat Kecamatan Pulau Hiri. Tujuan penelitian ini adalah untuk mendapatkan gambaran bentuk pelestarian, nilai dan pesan, serta faktor pendukung dan pengghambat pelestarian Dola Bololo di Kecamatan Pulau Hiri. Penelitian ini menggunakan metode deskriptif kualitatif. Berlokasi di Soa Dorari Isa. Data dikumpulkan menggunakan observasi, wawancara, dan dokumentasi. Analisis data menggunakan teknik reduksi, penyajian, dan kesimpulan. Hasil penelitian menunjukkan bahwa (1) Pelestarian tradisi lisan Dola Bololo oleh masyarakat Hiri melalui (a) Upacara adat, (b) Ritual, (c) Komunikasi tetuah, (d) Komunitas pemuda, dan (e) Media sosial; (2) Nilai dan pesan dalam tradisi lisan Dola Bololo masyarakat Hiri adalah (a) Mengenal batas diri, (b) Belajar mengikhlaskan, (c) Menjaga ucapan, (d) Mawas diri, (e) Memahami tujuan hidup; (3) Faktor pendukung dan penghambat pelestarian tradisi lisan Dola Bololo oleh masyarakat Kecamatan Pulau Hiri adalah, (a) Faktor pendukung ialah upacara adat, ritual, komunitas pemuda; (b) Faktor penghambat ialah fasilitas, pemerintah, sekolah, dan masyarakat.
IMPLEMENTASI PERMENDAGRI NOMOR 79 TAHUN 2018, TENTANG BADAN LAYANAN UMUM DAERAH BIDANG KESEHATAN DI RSUD KABUPATEN SUMEDANG
Authors: Eljawati Eljawati
Published: January 2024

Abstract

IMPLEMENTATION OF PERMENDAGRI NUMBER 79 OF 2018, CONCERNING REGIONAL PUBLIC SERVICE

BODIES HEALTH SECTOR AT SUMEDANG DISTRICT HOSPITAL

This study aims to determine the extent of the implementation that can be carried out by the Sumedang District Hospital in serving the Health Sector for the Sumedang District Community. This study used a qualitative method with descriptive analysis, and the data sources were obtained from secondary data and primary data. Secondary data was obtained from literature studies, documentation and scientific journals, while primary data was obtained from interviews with relevant officials who manage the health sector at Sumedang District Hospital and the community who need health services at Sumedang Hospital. The results obtained, that in its operation the Sumedang Hospital is based on Law number 44 of 2009, concerning Hospitals, and Permendagri number 79 of 2018, concerning Regional Public Service Agency (BLUD). The conclusion is that Sumedang General Hospital was established by the Sumedang Regent as a Work Unit that applies the financial management pattern of the Regional Public Service Agency (PPK-BLUD). And RSUD Sumedang is supported by medical personnel and medical professionals who are skilled and professional. The service is carried out 24 hours, with a service cycle that is well and precisely regulated, with a very humane aspect of medical and paramedical personnel.

Keywords: BLUD, Health and Hospital

 

Abstrak

Penelitian ini bertujuan untuk dapat mengetahui sejauhmana implementasi yang dapat dilakukan oleh RSUD Kabupaten Sumedang dalam melayani Bidang Kesehatan bagi Masyarakat Kabupaten Sumedang.Penelitian ini menggunakan metode kualitatif dengan analisis diskriptif, dan sumberdata diperoleh dari data sekunder dan data primer. Data sekunder didapat dari kajian literature, dokumentasi-dokumentasi dan jurnal -jurnal ilmiah, sedangkan data primer diperoleh dari hasil wawancara dengan pejabat terkait yang mengelola bidang kesehatan pada RSUD Kabupaten Sumedang dan Masyarakat yang membutuhkan pelayanan kesehatan di RSUD Sumedang. Hasil yang didapat, bahwa dalam operasionalnya RSUD Sumedang berdasarkan Undang- Undang nomor 44 Tahun 2009, tentang Rumah Sakit, dan Permendagri nomor 79 tahun 2018, tentang Badan Layanan Umum Daerah (BLUD). Simpulan bahwa RSUD Sumedang ditetapkan oleh Bupati Sumedang sebagai Satuan Kerja yang menerapkan pola pengelolaan keuangan Badan Layanan Umum Daerah (PPK-BLUD). Dan RSUD Sumedang didukung oleh tenaga medis dan para medis yang memiliki ketrampilan dan profesional. Pelayanan dilakukan 24 jam, dengan siklus pelayanan diatur secara baik dan tepat, dengan sangat humanis dari unsur tenaga-tenaga medis dan para medis.

Kata Kunci: BLUD, Kesehatan dan Rumah Sakit
PENGELOLAAN PIUTANG PAJAK BUMI DAN BANGUNAN PERDESAAN DAN PERKOTAAN DALAM MENINGKATKAN PENDAPATAN DAERAH DI KABUPATEN KATINGAN
Authors: Sinurat Marja , Simanjuntak Tumpak H. , Pratama Christian Anugrah
Published: January 2024

Abstract MANAGEMENT OF RURAL AND URBAN LAND AND BUILDING TAX RECEIVABLE IN INCREASING REGIONAL INCOME IN THE KATINGAN REGENCYThe government has transferred the Rural and Urban Land and Building Tax (PBB-P2) from the central tax  to a regional tax which aims to provide an additional source of regional original income (PAD) for regional  development. This transition resulted in an increase in PBB-P2 receivables in the regions. The purpose of this study is to analyze how to manage receivables, analysis of factors that influence the increase and decrease of PBB-P2 receivables. The method used is a qualitative method with data collection techniques through interviews and documentation. The data were analyzed based on George R. Terry’s theory of management functions and the analysis of PBB-P2 receivables management basically had not been carried out properly so that there was an increase in receivables. This increase in debt occurs because there has not been an update of tax subject and object data and the lack of competence of the tax management apparatus as well as the low awareness of the public to pay taxes. Efforts were made by making a PBB-P2 data collection application in Katingan Regency 

Keywords: Accounts Receivable Management; Rural and Urban Land and Building Tax (PBB-P2); Increase in Regional Original Income (PAD).

Abstrak Pemerintah telah mengalihkan Pajak Bumi dan Bangunan Perdesaan dan Perkotaan (PBB-P2) dari pajak pusat menjadi pajak daerah yang bertujuan memberikan tambahan sumber pendapatan asli daerah (PAD) bagi pembangunan daerah. Peralihan tersebut menjadikan peningkatan piutang PBB-P2 di daerah. Tujuan penelitian ini adalah menganalisis cara mengelola piutang, analisis faktor yang mempengaruhi peningkatan dan pengurangan piutang PBB-P2. Metode yang digunakan metode kualitatif dengan teknik pengumpulan data melalui wawancara dan dokumentasi. Data dianalisis berdasarkan teori fungsi manajemen George R. Terry dan analisa pengelolaan piutang PBB-P2 pada dasarnya belum terlaksana dengan baik sehingga terjadi peningkatan piutang. Peningkatan piutang tersebut terjadi karena belum dilakukan pembaharuan data subjek dan objek pajak dan kurangnya kompetensi aparatur pengelola pajak serta rendahnya kesadaran masyarakat untuk membaymembayar pajak. Upaya dilakukan dengan membuat aplikasi pendataan PBB-P2 di Kabupaten Katingan.

Kata kunci: Pengelolaan Piutang; Pajak Bumi dan Bangunan Perdesaan dan Perkotaan (PBB-P2); Peningkatan Pendapatan Asli Daerah (PAD).
Türk-Hırvat ilişkilerinin gazetelerdeki yansımalarının değerlendirilmesi (1991-1999)
Authors: ŠAPİNA Marko , DURAN Hasan , ÇİÇEK Aylin Ece
Published: January 2024

Özellikle internetin yaygınlaşmasından önceki döneme ait gazete makaleleri; o dönemin görüşlerine, belirli olayların kamuoyuna algılanışına ve sunuluşuna doğrudan bir bakış sunmaktadır. Bu nedenle, Hırvat-Türk ikili ilişkileri ile ilgili makalelerin analizi, tarihsel bağlama daha derin bir anlayış getirerek ikili ilişkiler ile toplumsal değişimlerinin daha iyi anlaşılmasına yardımcı olmaktadır. Bu çalışmada, 1991 yılından başlayarak 1999’un sonuna kadar Türk ve Hırvat gazetelerinde yayımlanan ve Hırvatistan ile Türkiye arasındaki ilişkileri ele alan gazete makaleleri analiz edilmiştir. İncelenen makalelerde genellikle olumlu bir anlatı bulunmuş; gazetelerin, okuyuculara detaylı açıklamalar ve

fotoğraflarla geniş bir bakış açısı sunmaya çalıştıkları görülmüştür. İncelenen metinler, ikili ilişkilerin daha da pekiştirilmesini teşvik etmiş, nadiren de dönemin Hırvatistan ve Türkiye cumhurbaşkanları Franjo Tuđman ve Süleyman Demirel’in yakınlığına yönelik eleştirel örneklere rastlanmıştır.
Thematic and Conceptual Analysis of the Journal of World Economy (Revista de Economía Mundial) Using SciMAT
Authors: Moral-Pajares Encarnación , Cobo-Martín Manuel Jesús , Caviedes-Conde Ángela Andrea , Gallego-Valero Leticia
Published: January 2024

This paper carries out a bibliometric study of the Journal of World Economy (Revista de Economía Mundial) for the period 2008 to 2021 using the SciMAT software, with the aim of discerning how the published research has evolved and the main areas of study have developed, as well as to indicate future lines that could be prioritized. The results obtained reveal that “economic growth” has been the journal’s main theme through the entire period and that “European Union” has been the basic area of research. At the same time, few articles have referred to highly topical issues such as the green transition of the world economy.
The future for the therapeutics of abdominal aortic aneurysm: engineered nanoparticles drug delivery for abdominal aortic aneurysm
Authors: Du Pengchong , Hou Yachen , Su Chang , Gao Jiamin , Yang Yu , Zhang Jinying , Cui Xiaolin , Tang Junnan
Published: January 2024

Abdominal aortic aneurysm (AAA) is a severe cardiovascular disease with a high mortality rate. Several screening and diagnostic methods have been developed for AAA early diagnosis. Open surgery and endovascular aortic repair (EVAR) are clinically available for patients who meet the indications for surgery. However, for non-surgical patients, limited drugs exist to inhibit or reverse the progression of aneurysms due to the complex pathogenesis and biological structure of AAA, failing to accumulate precisely on the lesion to achieve sufficient concentrations. The recently developed nanotechnology offers a new strategy to address this problem by developing drug-carrying nanoparticles with enhanced water solubility and targeting capacity, prolonged duration, and reduced side effects. Despite the rising popularity, limited literature is available to highlight the progression of the field. Herein, in this review, we first discuss the pathogenesis of AAA, the methods of diagnosis and treatment that have been applied clinically, followed by the review of research progressions of constructing different drug-loaded nanoparticles for AAA treatment using engineered nanoparticles. In addition, the feasibility of extracellular vesicles (EVs) and EVs-based nanotechnology for AAA treatment in recent years are highlighted, together with the future perspective. We hope this review will provide a clear picture for the scientists and clinicians to find a new solution for AAA clinical management.
Compassionate communication: a scoping review
Authors: Julia Grace Jacob , Romate John , Allen Joshua George , Rajkumar Eslavath
Published: January 2024

Empirical evidence from compassion literature reports the inherent difficulty in teaching compassion-related qualities and indicates the recent shift towards promoting interventions focusing on enhancing communication skills associated with compassionate care. Given the absence of a strong empirical and theoretical understanding of compassionate communication, the present scoping review identifies and integrates the definitions and theoretical approaches to compassionate communication based on the existing literature. A total of 5,813 records identified through an initial search in four databases (Scopus, Web of Science, PubMed and APA PsycNet) combined with the 49 obtained through manual search, underwent screening based on PRISMA-ScR guidelines. A total of 57 articles that met the eligibility criteria were finalised for narrative synthesis (which included a thematic and content analysis). The review serves as a constructive critique of the contradictions and issues with empirical evidence on verbal and non-verbal compassion and portrays the concept to exist beyond its impact on the alleviation of suffering by describing compassionate communication in light of (1) cognitive aspects, (2) affective aspects, (3) behavioural/state aspects (4) relational aspects, (5) self-compassion, (6) mutuality, (7) individual-specific virtuous traits or values. The necessity for an integrative definition of compassionate communication and a theoretical framework that links the components of compassionate communication with its antecedents and outcomes is highlighted. The review is a valid and reliable source of guidance for future research on theory, education, and interventions on compassionate communication. The findings of the review can be interpreted in light of both contemporary and traditional communication theory, having practical implications for different domains of society (i.e., family, workplace relationships, business, and healthcare).
Pneumonia detection by binary classification: classical, quantum, and hybrid approaches for support vector machine (SVM)
Authors: Guddanti Sai Sakunthala , Padhye Apurva , Prabhakar Anil , Tayur Sridhar
Published: January 2024

Early diagnosis of pneumonia is crucial to increase the chances of survival and reduce the recovery time of the patient. Chest X-ray images, the most widely used method in practice, are challenging to classify. Our aim is to develop a machine learning tool that can accurately classify images as belonging to normal or infected individuals. A support vector machine (SVM) is attractive because binary classification can be represented as an optimization problem, in particular as a Quadratic Unconstrained Binary Optimization (QUBO) model, which, in turn, maps naturally to an Ising model, thereby making annealing—classical, quantum, and hybrid—an attractive approach to explore. In this study, we offer a comparison between different methods: (1) a classical state-of-the-art implementation of SVM (LibSVM); (2) solving SVM with a classical solver (Gurobi), with and without decomposition; (3) solving SVM with simulated annealing; (4) solving SVM with quantum annealing (D-Wave); and (5) solving SVM using Graver Augmented Multi-seed Algorithm (GAMA). GAMA is tried with several different numbers of Graver elements and a number of seeds using both simulating annealing and quantum annealing. We found that simulated annealing and GAMA (with simulated annealing) are comparable, provide accurate results quickly, competitive with LibSVM, and superior to Gurobi and quantum annealing.
Quantum annealing research at CMU: algorithms, hardware, applications
Authors: Tayur Sridhar , Tenneti Ananth
Published: January 2024

In this mini-review, we introduce and summarize research from the Quantum Technologies Group (QTG) at Carnegie Mellon University related to computational experience with quantum annealing, performed in collaboration with several other institutions including IIT-Madras and NASA (QuAIL). We present a novel hybrid quantum-classical heuristic algorithm (GAMA, Graver Augmented Multi-seed Algorithm) for non-linear, integer optimization, and illustrate it on an application (in cancer genomics). We then present an algebraic geometry-based algorithm for embedding a problem onto a hardware that is not fully connected, along with a companion Integer Programming (IP) approach. Next, we discuss the performance of two photonic devices - the Temporal Multiplexed Ising Machine (TMIM) and the Spatial Photonic Ising Machine (SPIM) - on Max-Cut and Number Partitioning instances. We close with an outline of the current work.
Plasma levels of autophagy regulator Rubicon are inversely associated with acute coronary syndrome
Authors: Grazide Marie-Hélène , Ruidavets Jean-Bernard , Martinet Wim , Elbaz Meyer , Vindis Cécile
Published: January 2024

Background

The discovery of novel biomarkers that improve current cardiovascular risk prediction models of acute coronary syndrome (ACS) is needed for the identification of very high-risk patients and therapeutic decision-making. Autophagy is a highly conserved catabolic mechanism for intracellular degradation of cellular components through lysosomes. The autophagy process helps maintain cardiac homeostasis and dysregulated autophagy has been described in cardiovascular conditions. Rubicon (Run domain Beclin-1-interacting and cysteine-rich domain-containing protein) is a key regulator of autophagy with a potential role in cardiac stress.

Objectives

The aims of the present study were to assess whether changes in circulating Rubicon levels are associated with ACS and to evaluate the added value of Rubicon to a clinical predictive risk model.

Methods and results

The study population included ACS patients (n = 100) and control subjects (n = 99) at high to very high cardiovascular risk but without known coronary event. Plasma Rubicon levels were measured in the whole study population by enzyme-linked immunosorbent assay. Multivariate logistic regression analyses established that Rubicon levels were inversely associated with ACS. A receiver operating characteristic curve analysis demonstrated that the addition of Rubicon improved the predictive performance of the model with an increased area under the curve from 0.868 to 0.896 (p = 0.038).

Conclusions

Plasma levels of the autophagy regulator Rubicon are associated with ACS and provide added value to classical risk markers for ACS.
A Bayesian network-based approach for identifying risk factors and predicting ischemic stroke in infective endocarditis patients
Authors: Yuan Boyi , Wang Chaobin , Fan Zexin , Liu Chun , Fang Libo , Ma Lin , Zou Wenlong , Yuan Guobin , Liu Guangzhi
Published: January 2024

Objective

This study aimed to seek the risk factors and develop a predictive model for ischemic stroke (IS) in patients with infective endocarditis (IE) utilizing a Bayesian network (BN) approach.

Methods

Data were obtained from the electronic medical records of all adult patients at three hospitals between 1 January 2018, and 31 December 2022. Two predictive models, logistic regression and BN, were used. Patients were randomly assigned to the training and test sets in a 7:3 ratio. We established a BN model with the training dataset and validated it with the testing dataset. The Bayesian network model was built by using the Tabu search algorithm. The areas under the receiver operating characteristic curve (AUCs), calibration curve, and decision curve were used to evaluate the prediction performance between the BN and logistic models.

Results

A total of 542 patients [mean (SD) age, 49.6 (15.3) years; 137 (25.3%) female] were enrolled, including 151 (27.9%) with IS and 391 (72.1%) without IS. Hyperlipidemia, hypertension, age, vegetation size (>10 mm), S. aureus infection, and early prosthetic valve IE were closely correlated with IS. The BN models outperformed the logistic regression in training and testing sets, with accuracies of 76.06% and 74.1%, AUC of 0.744 and 0.703, sensitivities of 25.93% and 20.93%, and specificities of 96.27% and 90.24%, respectively.

Conclusion

The BN model is more efficient than the logistic regression model. Therefore, BN models may be suitable for the early diagnosis and prevention of IS in IE patients.
Impact of clinical variables on outcomes in refractory cardiac arrest patients undergoing extracorporeal cardiopulmonary resuscitation
Authors: Demers Simon-Pierre , Cournoyer Alexis , Dagher Olina , Noly Pierre-Emmanuel , Ducharme Anique , Ly Hung , Albert Martin , Serri Karim , Cavayas Yiorgos Alexandros , Ben Ali Walid , Lamarche Yoan
Published: January 2024

Background

In the past two decades, extracorporeal resuscitation (ECPR) has been increasingly used in the management of refractory cardiac arrest (CA) patients. Decision algorithms have been used to guide the care such patients, but the effectiveness of such decision-making tools is not well described. The aim of this study was to compare the rate of survival with a good neurologic outcome of patients treated with ECPR meeting all criteria of a clinical decision-making tool for the initiation of ECPR to those for whom ECPR was implemented outside of the algorithm.

Methods

All patients who underwent E-CPR between January 2014 and December 2021 at the Montreal Heart Institute were included in this retrospective analysis. We dichotomized the cohort according to adherence or non-adherence with the ECPR decision-making tool, which included the following criteria: age ≤65 years, initial shockable rhythm, no-flow time <5 min, serum lactate <13 mmol/L. Patients were included in the “IN” group when they met all criteria of the decision-making tool and in the “OUT” group when at least one criterion was not met.

Main outcomes and measures

The primary outcome was survival with intact neurological status at 30 days, defined by a Cerebral Performance Category (CPC) Scale 1 and 2.

Results

A total of 41 patients (IN group, n = 11; OUT group, n = 30) were included. A total of 4 (36%) patients met the primary outcome in the IN group and 7 (23%) in the OUT group [odds ratio (OR): 1.88 (95% CI, 0.42–8.34); P = 0.45]. However, survival with a favorable outcome decreased steadily with 2 or more deviations from the decision-making tool [2 deviations: 1 (11%); 3 deviations: 0 (0%)].

Conclusion and relevance

Most patients supported with ECPR fell outside of the criteria encompassed in a clinical decision-making tool, which highlights the challenge of optimal selection of ECPR candidates. Survival rate with a good neurologic outcome did not differ between the IN and OUT groups. However, survival with favorable outcome decreased steadily after one deviation from the decision-making tool. More studies are needed to help select proper candidates with refractory CA patients for ECPR.
Emotional competence profile in secondary school counselors: controversy or need?
Authors: Fernández Tilve María Dolores , Malvar Méndez María Laura , Varela Tembra Juan José
Published: January 2024

It is out of doubt that little attention is paid to the emotional competences of secondary school counselors in research activity, as well as in their initial and ongoing training. It seems that emotional well-being is still a pending issue that may even generate some controversy, even though, today, it is defined as a clear strategy in mental health plans. Undoubtedly, we are facing a content that facilitates the contrast of points of view and social commitment as an inherent part of the democratic process. Therefore, it was decided to carry out a study, of enormous relevance, with the purpose of knowing the perceptions of secondary school counselors within the Autonomous Community of Galicia regarding emotional competences for an ideal counseling practice in complex times and moments with great challenges in the field of educational equity. Specifically, an evaluation study was carried out on the level of training received by school counselors in emotional competences and thus be able to have a diagnosis, identifying possible strengths and weaknesses. A study with a quantitative based methodology which uses the questionnaire for data collection as a main research technique. The findings obtained suggest that the quality of the teaching and learning processes in secondary schools would be substantially improved if the emotional competence profile of the counselors was considered. In particular, the interest that emotional competences arouse in counselors is confirmed, at the same time, they recognize that they can help them properly to manage the relationship processes and, the personal balance. This research, one of the first carried out in Galicia on emotional competences in secondary school counselors, provides empirical data of great interest for future training plans that are more in line with social and professional expectations, since it provides an x-ray unique, revealing, valid and real statement of the state of the matter.
Integrating EQUIP competency-based training into a university curriculum: a qualitative inquiry with students and faculty at Makerere University in Uganda
Authors: Ndeezi Morris , Pedersen Gloria A. , Alipanga Benjamin , Luberenga Ibrahim , Kohrt Brandon A. , Kasujja Roscoe
Published: January 2024

Introduction

Competency-based training has gained prominence in clinical psychology education, emphasizing practical skills acquisition. The EQUIP competency-based approach, recognized for its effectiveness in in-service training, raises questions about its feasibility and utility in pre-service education.

Methods

Faculty and supervisors were trained in and applied EQUIP competency-based assessment and techniques with current graduate students. A cohort comprising 15 graduate students, 12 faculty members, and supervisors from Butabika National Referral Mental Health and Teaching Hospital participated in focus group discussion and key informant interviews. Qualitative data was collected from 1st August 2022 to 4th August 2022. Thematic analysis identified three central themes.

Findings

The first theme reveals participants’ recognition of EQUIP’s feasibility in standardizing competence levels and addressing curriculum gaps. An extended training period, approximately 15 h, was identified as crucial to enhance educators’ and supervisors’ confidence in implementing the approach. The second theme emphasizes the pivotal role of role-play in competency-based training, transforming initial apprehension into constructive learning. Lastly, feedback emerged as a crucial component, with participants highlighting its role in fostering self-assuredness and refining skills.

Conclusion

The study emphasizes the importance of robust training in competency-based methodologies. The EQUIP approach’s potential in clinical psychology education is evidenced by its alignment with research outcomes. Beyond this, the study advocates for longitudinal research to assess sustained engagement with EQUIP resources and their long-term impact. This research not only advances the discourse on competency-based training but also sets the stage for continuous improvements in clinical psychology education.
Identification of composite power quality disturbances based on relative position matrix
Authors: Liu Zijun , Zhang Huaying , Lv Zhining , Jia Honglei , Liang Xiaorui , Wang Qing
Published: January 2024

With the integration of large-scale nonlinear loads and distributed power sources into the grid, composite power quality disturbances (PQDs) events are becoming increasingly common, which significantly degrade the quality of power supply. Therefore, this paper focuses on studying the accurate classification of composite PQDs to mitigate the risk of power quality deterioration. However, traditional classification methods perform barely satisfactory in terms of accuracy and robustness in the classification of PQDs. To address these issues, this paper proposes a method for recognizing composite PQDs based on relative position matrix (RPM). Initially, utilizing the RPM method, the initial one-dimensional PQD time series data is transformed into two-dimensional image data while preserving its high-frequency characteristics. This process results in the creation of an informative and feature-rich image training set. Subsequently, an end-to-end framework for PQDs classification was developed. The framework utilizes convolutional neural networks to automatically extract multi-scale spatial and temporal features from image data. This design aims to automate the classification of composite PQDs, eliminating the need for labor-intensive manual signal processing and feature extraction. This integration ensures a more accurate and robust classification. Finally, the proposed method is tested on a case involving 30 types of PQDs at varying noise levels and compared with existing power quality disturbance classification methods, and results show that the proposed method has better performance than the previously established methods.
Complex terrains and wind power: enhancing forecasting accuracy through CNNs and DeepSHAP analysis
Authors: Konstantinou Theodoros , Hatziargyriou Nikos
Published: January 2024

Accurate prediction of wind power generation in regions characterised by complex terrain is a critical gap in renewable energy research. To address this challenge, the present study articulates a novel methodological framework using Convolutional Neural Networks (CNNs) to improve wind power forecasting in such geographically diverse areas. The core research question is to investigate the extent to which terrain complexity affects forecast accuracy. To this end, DeepSHAP—an advanced interpretability technique—is used to dissect the CNN model and identify the most significant features of the weather forecast grid that have the greatest impact on forecast accuracy. Our results show a clear correlation between certain topographical features and forecast accuracy, demonstrating that complex terrain features are an important part of the forecasting process. The study’s findings support the hypothesis that a detailed understanding of terrain features, facilitated by model interpretability, is essential for improving wind energy forecasts. Consequently, this research addresses an important gap by clarifying the influence of complex terrain on wind energy forecasting and provides a strategic pathway for more efficient use of wind resources, thereby supporting the wider adoption of wind energy as a sustainable energy source, even in regions with complex terrain.
Residential surrounding greenness is not associated with incident breast cancer in young women in Ontario, Canada
Authors: Waddingham Claudia M. , Villeneuve Paul J. , Le Provost Blandine , Parent Marie-Élise , Brook Jeffrey R. , Lavigne Eric , Harris Shelley A.
Published: January 2024

Objectives

Environmental exposures play an important role in the development of breast cancer. The incidence of breast cancer is increasing in young women, and its etiology differs from that of older women. Epidemiological studies have provided mixed evidence about whether proximity to urban greenness reduces the risk of breast cancer, but few studies have evaluated this risk in younger women.

Methods

We investigated associations between residentially-based measures of greenness and breast cancer among participants of the Ontario Environmental Health Study (OEHS). The OEHS was a case–control study of Ontario women, 18–45 years of age, who provided questionnaire data between 2013 and 2015. The study included 465 cases diagnosed with a pathologically confirmed primary diagnosis of breast cancer, and 242 population-based controls. Residentially-based measures of greenness, the Normalized Difference Vegetation Index (NDVI) and tree coverage percentage, at 100-, 250-, 500-, and 1,000-m buffers, were assigned to the residential histories of the women. Odds ratios and their 95% confidence intervals (CIs) were estimated using logistic regression, adjusted for potential confounders including traffic-related air pollution [nitrogen dioxide (NO2)].

Results

We found no evidence that an increase in NDVI or tree coverage were significantly associated with breast cancer. The adjusted odds ratio of breast cancer in relation to an interquartile range increase (IQR) in the NDVI (500-m buffer) was 0.86 (95% CI = 0.59–1.13). Similarly, the odds ratio of breast cancer among those in the highest quartile of tree coverage (500-m buffer) relative to the lowest was 1.11 (95% CI = 0.59–2.07). Risk estimates for both measures of greenness did not vary substantially across different buffer distances. Exposure to NO2 was an important confounder in these associations.

Conclusions

Our findings do not support the hypothesis that residential greenness reduces the risk of breast cancer among young women, while highlighting the importance of adjusting for air pollution.
Assessing biodiversity and regulatory ecosystem services in urban water bodies which serve as aqua-Nature-based Solutions
Authors: Martín Muñoz Silvia , Schoelynck Jonas , Tetzlaff Doerthe , Debbaut Robrecht , Warter Maria , Staes Jan
Published: January 2024

In sight of a growing urban population and intensified extreme weather events, cities must integrate in their urban planning elements to both reduce their impact (i.e., air and water pollution, degradation of habitats, loss of biodiversity) and increase their resilience to climate change. In contrast to engineering solutions, which normally not only fail to adequately address these issues but often also exacerbate them, Nature-based Solutions are an efficient strategy which can help cities become more sustainable. Aqua-Nature-based Solutions (aNBS) tackle water-related hazards by enhancing water regulation and mitigating flood and drought impacts. However, under a warming climate, aNBS are expected to often dry-out, changing biodiversity and the ecosystem services they support. The aim of this study is to compare the biodiversity of temporarily and permanently wet urban waterbodies which function as aNBS. We selected two pond complexes with different hydroperiod (i.e., different duration, amplitude and frequency of inundation) and studied the riparian vegetation and aquatic macroinvertebrate biodiversity. The Multimetric Macroinvertebrate Index of Flanders was used to determine the macroinvertebrate biodiversity and to assess water quality of the ponds. Using water stable isotopes and piezometers, the hydrological dynamics were studied in order to identify the water regulating ecosystem services these ponds deliver. The results showed that the selected pond complexes have a high plant biodiversity, particularly in temporary ponds. Water quality ranged from moderate to poor and macroinvertebrate biodiversity tended to be greater in permanent ponds. Plant and macroinvertebrate alien species were also found in the aNBS. Regarding water regulating ecosystem services, the pond complexes enhanced infiltration and groundwater recharge, providing resilience to both flooding and drought. Our findings corroborate previous studies on the need of diversifying urban ponds’ hydroperiod to support biodiversity. Thus, integrating well-designed aNBS into urban planning might be a way to make cities more resilient to water climate-related hazards while enhancing biodiversity.
Plasmodium falciparum remains the dominant parasite affecting children despite decades of implementing vector control in two villages of Wolaita Zone, Southwest Ethiopia
Authors: Elias Shimels , Massebo Fekadu
Published: January 2024

Background

Malaria is still a significant public health concern, and its prevention and control measures have different impacts in different areas. This study assesses the prevalence of malaria and the effectiveness of routine malaria control programmes such as indoor residual spray (IRS) in two Ethiopian villages.

Methods

The Kebeles (villages) were purposefully selected based on their malaria prevalence rates. A parasitology survey was conducted in Fango-Gelchecha pre- and post-IRS implementation, whereas in Shochora-Abela it was only conducted post-IRS implementation. The IRS was implemented as part of the routine malaria control programme in August 2017. Every fourth house from the village registration list was systematically selected, resulting in a sample of 300 households per village. A total of 3,075 individuals were enrolled for malaria testing using microscopy.

Results

After three to four months of application of IRS in August 2017, 59 malaria cases were confirmed, resulting in an overall prevalence of 1.9% (95% CI: 1.5–2.5). Of the positive cases, 18 cases (0.59%: 95% CI: 1.3–1.8) were from Shochora-Abela village, and 41 cases (1.33%: 95% CI: 1.1–1.3) were from Fango-Gelchecha. About age categories, the prevalence of malaria was 10.1% (95% CI: 5.9–15.9) among children under five, 4.7% (95% CI: 3.3–6.4) in children aged 5–14, and only 0.32% (95% CI: 0.13–0.67) in the age group 15 and above. Overall, P. falciparum was the dominant malaria parasite, accounting for 69.5% (95% CI: 56.1–80.8), while P. vivax malaria accounted for 30.5% (95% CI: 19.2–43.8). The malaria prevalence in Fango-Gelchecha village was 3.1% (95% CI: 2.3–4.0) before IRS and 2.6% (95% CI: 1.8–3.5) after IRS application. In the village of Shochora-Abela, the prevalence of malaria post-IRS was 1.2% (95% CI: 0.7–1.9), but the prevalence prior to IRS was not evaluated.

Conclusions

Plasmodium falciparum is the predominant parasite in the villages, mainly affecting children under five. Therefore, protecting young children should be the top priority for reducing infection burdens.
Phylogenetic conservation of Trop-2 across species—rodent and primate genomics model anti-Trop-2 therapy for pre-clinical benchmarks
Authors: Guerra Emanuela , Trerotola Marco , Relli Valeria , Lattanzio Rossano , Boujnah Khouloud , Travali Nicole , Moschella Antonino , Todaro Paolo , Pierdomenico Laura , Di Pietro Roberta , Tinari Nicola , Alberti Saverio
Published: January 2024

A phylogenetic conservation analysis of Trop-2 across vertebrate species showed a high degree of sequence conservation, permitting to explore multiple models as pre-clinical benchmarks. Sequence divergence and incomplete conservation of expression patterns were observed in mouse and rat. Primate Trop-2 sequences were found to be 95%–100% identical to the human sequence. Comparative three-dimension primate Trop-2 structures were obtained with AlphaFold and homology modeling. This revealed high structure conservation of Trop-2 (0.66 ProMod3 GMQE, 0.80–0.86 ± 0.05 QMEANDisCo scores), with conservative amino acid changes at variant sites. Primate TACSTD2/TROP2 cDNAs were cloned and transfectants for individual ORF were shown to be efficiently recognized by humanized anti-Trop-2 monoclonal antibodies (Hu2G10, Hu2EF). Immunohistochemistry analysis of Macaca mulatta (rhesus monkey) tissues showed Trop-2 expression patterns that closely followed those in human tissues. This led us to test Trop-2 targeting in vivo in Macaca fascicularis (cynomolgus monkey). Intravenously injected Hu2G10 and Hu2EF were well tolerated from 5 to 10 mg/kg. Neither neurological, respiratory, digestive, urinary symptoms, nor biochemical or hematological toxicities were detected during 28-day observation. Blood serum pharmacokinetic (PK) studies were conducted utilizing anti-idiotypic antibodies in capture-ELISA assays. Hu2G10 (t1/2 = 6.5 days) and Hu2EF (t1/2 = 5.5 days) were stable in plasma, and were detectable in the circulation up to 3 weeks after the infusion. These findings validate primates as reliable models for Hu2G10 and Hu2EF toxicity and PK, and support the use of these antibodies as next-generation anti-Trop-2 immunotherapy tools.
Adverse events of neoadjuvant combination immunotherapy for resectable cancer patients: a systematic review and meta-analysis
Authors: Feng Yuqian , Guo Kaibo , Jin Huimin , Jiang Jing , Wang Menglei , Lin Shengyou
Published: January 2024

Background

Neoadjuvant combination immunotherapy is changing the treatment landscape for patients with cancer. Exploring the incidence of immune-related adverse events (irAEs) in relation to this novel approach may provide valuable insights for future clinical investigations.

Methods

This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed, Embase, Cochrane Library, American Society of Clinical Oncology (ASCO), and European Society of Medical Oncology (ESMO) websites were searched for all relevant literature from their inception to November 24, 2023. We then extracted the required data from the included studies and used the R software to analyze the pooled incidence of irAEs. Subgroup analyses examined the pooled incidence of irAEs according to cancer and combination types using a random-effects model.

Results

Sixteen studies involving 501 patients were included in the meta-analysis. Considering the heterogeneity of the study design, we analyzed the randomized controlled studies (RCTs) and the single-arm studies separately. In RCTs, the incidence of any-grade irAEs was 95.0% (95% confidence interval [CI] 87.3-99.3) and that of grade ≥3 irAEs was 24.0% (95% CI 13.7-36.0). In single-arm studies, the incidence of any-grade irAEs was 89.4% (95% CI 75.0-98.0) and grade ≥3 irAEs was 20.3% (95% CI 8.7-35.2). In both RCTs and single arms, the most common any- grade irAEs were rash and fatigue, while the most common grade ≥3 irAEs was abnormal liver function and colitis. Due to irAEs, 9.4% of patients in RCTs and 6.9% of patients in single-arm studies did not complete the prescribed neoadjuvant treatment cycle.

Conclusion

This study comprehensively summarized the incidence of irAEs in neoadjuvant combination immunotherapy. The occurrence of irAEs varies depending on the cancer and combination types. Our meta-analysis provides clinicians with essential guidance for the management of patients with cancer.

Systematic review registration

https://www.crd.york.ac.uk/prospero, identifier CRD42023387969.
Lactobacillus rhamnosus ameliorates acne vulgaris in SD rats via changes in gut microbiota and associated tryptophan metabolism
Authors: Huang Yukun , Huang Yaxin , Xia Dengmei , Liu Lu , Xiong Xia , Ouyang Yongliang , Deng Yongqiong
Published: January 2024

Background

The depletion of beneficial bacteria in the gut has been found in patients with acne vulgaris, and in previous studies, the supplement of Lactobacillus rhamnosus led to the improvement of adult acne. Nevertheless, the potential mechanism of L. rhamnosus in the amelioration of acne vulgaris has not been elucidated yet.

Methods

To mimic the human intestinal environment, a pseudo-germ-free rat model was used, and then gut microbiota from healthy individuals and acne patients were transplanted into rats. The effects of L. rhamnosus and tryptophan (Trp) metabolites on a rat acne model were investigated by gavage. Then, 16S rRNA analysis and targeted measurement of metabolites were performed to discover the differences in gut microbiota and metabolites between groups. Finally, HaCaT cells pretreated with Cutibacterium acnes were employed to validate the effect and mechanism of Trp metabolites on acne.

Results

L. rhamnosus significantly improved acne-like symptoms in rats by suppressing the level of inflammatory cytokines such as IL-1β, IL-6, and TNF-α. L. rhamnosus induced an increase in the production of indole-3-acetic acid (IAA) and indole via targeted Trp metabolic analyses. Furthermore, L. rhamnosus promoted bacterial diversity and also enhanced the Firmicutes/Bacteroidota (F/B) ratio, which was positively related to both IAA and indole. Finally, the roles of IAA and indole in alleviating acne vulgaris were confirmed both in vitro and in vivo, which could be reversed by AhR inhibitors.

Conclusion

Our study demonstrated that L. rhamnosus could exert its therapeutic effects on acne vulgaris by modulating the gut microbiota and regulating associated Trp metabolites.