bluuebunny/crossref_metadata_2025 huggingface dataset:
A BIOESTIMULAÇÃO PROPORCIONADA PELA LASERTERAPIA DE BAIXA INTENSIDADE NA OSSEOINTEGRAÇÃO DE IMPLANTES DENTÁRIOS: REVISÃO DE LITERATURA
Authors: Lima Ramiro Lopes , Costa Rosyelma Pinheiro , Brito Mateus Henrique Matos , Oliveira Adrielle Karoline Estácio da Silva , Braz Marceli França , Silva Sabryna de Kássia M. Serra da , Andrade Hildeniza Bianca Soares , Souza Luciana de Melo , Santos Yasmin de Aguiar Valadares , Rodrigues Vandilson Pinheiro , Lage Lucas Meneses
Published: August 2023

A implantodontia revolucionou a odontologia e os conceitos de reabilitação oral estética e funcional pela proposta de osseointegração de implantes dentários, tornando-se uma excelente alternativa na reabilitação de pacientes com perda dental parcial ou total. No entanto, o processo de osseointegração do implante dentário demanda tempo para que a reparação tecidual seja concluída. Nesse sentido, ao longo dos anos surge a busca por prognósticos clínicos e cirúrgicos mais previsíveis e favoráveis com o propósito de acelerar a osseointegração e proporcionar um pós-operatório mais confortável ao paciente. Diante desse contexto, o laser de baixa potência surge como uma alternativa eficaz acelerando o processo de cicatrização, efeitos analgésicos e antiflamatórios. A proposição do presente trabalho foi realizar uma revisão de literatura para avaliar a biomodulacão proporcionada com a aplicação do laser de baixa potência no pós-operatório e suas contribuições na otimização do processo de osseointegração de implantes diminuindo o tempo de recuperação do paciente. A busca bibliográfica foi realizada nas bases de dados SciELO, Lilacs e PubMed, por meio da combinação das seguintes palavras chaves consideradas descritores no DeCS (Descritores em ciências de Saúde): laser terapia, osseointegração, cicatrização, osso, terapia com luz de baixa intensidade, implante dentário endósseo e selecionando-se os artigos datados entre 2010 e 2022. Quatorze artigos foram selecionados de acordo com os critérios de inclusão e exclusão e lidos na íntegra. Concluiu-se, que o uso do laser de baixa potência no pós-operatório otimiza o processo de osseointegração de implantes dentários.

Palavras-chave: Osseointegração; Laser de Baixa Potência; Implantes Dentários.
PINO DE FIBRA DE VIDRO E OS NÚCLEOS METÁLICOS FUNDIDOS: uma revisão narrativa
Authors: Fonseca Werbeth Mota , Coelho Denise Fontenelle Cabral , Rodrigues Tatiana Hassin Costa , Vaz Adriana Cutrim de Mendonça , Ladeira Lorena Lúcia Costa , Costa Elisa Miranda , Cavassana Marcela Mayana Pereira Franco
Published: August 2023

Retentores intrarradicluares têm sido empregados na odontologia com o intuito de recuperar a estrutura do dente que foi perdida. Dentre os materiais usados como retentores, destacam-se os núcleos metálicos fundidos e os pinos de fibra de vidro. O objetivo deste trabalho foi comparar os pinos de fibra de vidro com os núcleos metálicos fundidos, a fim de observar suas diferenças e principais características. A metodologia do presente estudo consiste em uma revisão de literatura que teve uma abordagem qualitativa, onde foi realizada uma pesquisa bibliográfica referente a temática de comparação entre os pinos de fibra de vidro e os núcleos metálicos fundidos, foram utilizados pesquisas dos últimos 10 anos (2012 a 2022), utilizando os seguintes bancos de dados: Google acadêmico, SCIELO, PUBmed e LILACS. e os descritores utilizados foram, “Pinos dentários”, “reabilitação” e “técnica para retentor intrarradicular”.Desse modo ambas as opções são viáveis para o tratamento de dentes com estrutura comprometidas. Embora existam diferenças entre esses materiais, como a incidência de falhas relacionadas à fratura radicular e à decimentação, a taxa de sobrevivência de ambos os sistemas foi similar. Ressalta-se a importância do processo da cimentação, pois a cimentação adesiva, se adequada, pode reduzir significativamente as falhas por decimentação. Embora haja grande diferenças, os dois tipos de retentores avaliados são adequados para reabilitação de dentes comprometidos, a maior falha dos pinos metálicos é a fratura do dente remanescente enquanto que a decimentação é a principal falha dos pinos de fibra de vidro, que pode ser compensada pela técnica de cimentação adequada.

Palavras-chave: Pinos Dentários, Reabilitação, Técnica para retentor intrarradicular.
INSTALAÇÃO DE IMPLANTE IMEDIATO APÓS EXODONTIA ATRAUMÁTICA: REVISÃO DE LITERATURA
Authors: Nascimento Cleonilde Ferreira do , Silva Lais Sousa , Pacheco Adria Sumaia Belfort , Martins Lorenna Karynni Ribeiro , Silva Daniela de Oliveira da , Araújo Lucila Cristina Rodrigues , Galdez Neurinéia Margarida Alves de Oliveira , Rodrigues Vandilson Pinheiro , Lage Lucas Meneses
Published: August 2023

Esse trabalho se dispõe a fazer uma abordagem com intuito de esclarecer fatores que agregam vantagens, desvantagens e indicação em relação a técnica de reabilitação oral com implantes imediatos em alvéolos frescos. Todo procedimento, para ter sucesso, precisa de um planejamento, e na implantodontia não é diferente. Os implantes imediatos em alvéolos frescos são instalados logo após a exodontia do elemento dentário usando o mesmo ato cirúrgico, com isso ganha tempo na evolução do procedimento, diminui os custos para o paciente, previne a reabsorção óssea do alvéolo e obtém uma maior taxa de sucesso do implante. Para que tenha sucesso são necessários alguns aspectos fundamentais como a cirurgia minimamente atraumática, curetagem do alvéolo e preservação das paredes alveolares existem também as desvantagens, pois nem todos os pacientes estão aptos a fazer esse procedimento, alguns aspectos que impossibilitam esse tipo de tratamento são: tumores, perda da tabua óssea, alvéolo largo, ausência de espaço, presença de grande área de infecção, osteoporose e diabetes descompensada. Os implantes imediatos comparados aos implantes tardios têm mostrado bastante similaridade e os pacientes têm se mostrado bastante satisfeitos com os resultados dos implantes imediatos em alvéolo fresco, alegando ter redução de custos, eliminação da segunda cirurgia, melhora da autoestima, redução das tensões psicológicas.

Palavras-chaves: Implantes Imediatos, Exodontia Atraumática, Implantes em Alvéolos Frescos, Osseointegração.
Atual Movimento Bíblico Católico no Brasil (I)
Authors: Richtmann Flodoaldo Proença
Published: August 2023

Talvez melhor se intitulasse nosso trabalho: “O atual movimento católico de renovação bíblica no Brasil”. Estamos, com efeito, em face de um movimento renovador de âmbito universal, mas que se desenvolve no seio da Igreja — temporal e espacialmente — em ritmos desiguais, dadas às diferentes ambiências tanto de momento histórico quanto de situação geográfica, social e cultural...
International strategic academic partnerships: the EU and China’s experience
Authors: Sbruieva Alina Anatoliivna , Chu Ying
Published: August 2023

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Comparative analysis of solar heaters and heat exchangers in residential water heating
Authors: Anand Kishorbhai Patel
Published: August 2023

This research shows the comparative analysis between the solar heater and the heat exchanger efficiency. This is used for water heating in this project to show the use of this for residential purposes. The efficiency of these two is calculated in this project which helps to know the efficiency of each model in the water heating purpose. In this research process, a suitable set of comparisons has been drawn between the heat exchanger and water heater that have been worked on based on the effective solar energy. Effective energy usage provides a suitable beneficial impact in Favor of using this residential water heating system of heat exchangers. Detailed information has been represented in the background sections along with rationale aspects where the issues along with their remedies have been depicted.
PENGARUH MEDIA PERMAINAN CONGKLAK UNTUK MENINGKATKAN KEMAMPUAN MENGENAL KONSEP BILANGAN PADA SISWA KELOMPOK A DI TK MUSLIMAT NU 272 BAITURROHIEM DUDUKSAMPEYAN
Authors: Arifiyah Imanda , Lilawati Agustien
Published: August 2023

ABSTRAK

Pembelajaran di usia anak-anak tidak jauh dengan kegiatan bermain. Karena bermain sendiri merupakan dunia mereka. Apapun yang anak-anak pelajari di sekolah pasti menggunakan metode bermain dalam belajarnya. Namun kemampuan setiap anak dalam menerima pembelajaran berbeda-beda. Seperti halnya di TK Muslimat NU 272 Baiturrohiem Duduksampeyan pada siswa kelompok A. Kemampuan mengenal konsep bilangan pada anak menjadi masalah utama dalam penelitian ini. Penelitian ini menggunakan pendekatan kuantitatif dengan jenis eksperimen. Desain yang digunakan dalam penelitian ini adalah Pretest-Posttest One Group Design. Dalam penelitian ini mengambil sampel sebanyak 18 siswa yang artinya pada penelitian ini menggunakan statistik non parametrik. Pada data menunjukkan nilai rata-rata pada pretest dan posttest 153 meningkat menjadi 192 saat sudah diberikan treatment. Berdasarkan output test statistic, Thitung > Ttabel yaitu 3.320 > 1.734 . Jadi dapat dikatakan bahwa Ha diterima yang berarti ada pengaruh media permainan congklak untuk meningkatkan kemampuan mengenal konsep bilangan pada siswa kelompok A di TK Muslimat NU 272 Baiturrohiem Duduksampeyan.

Kata Kunci: Media Permainan Congklak, Kemampuan Mengenal Konsep Bilangan
ICOR Analysis on Inequality in Maluku Development
Authors: Tipka Jefri
Published: August 2023

The geographical condition of Maluku Province, which is in the form of an archipelago and the uneven distribution of investment, is one of the causes of the development inequality among regions in Maluku Province. Investment as measured by using ICOR can help to see efficiency in investment activities, so this research aims to see the role of investment in relation to equitable development during the 2011-2020 period in Maluku Province. The Linear Regression Method is used to measure how much influence the investment has on the level of unemployment in Maluku Province. The results show that investment is very influential on reducing inequality and helping equality development in Maluku Province. This finding serves as input for the government that until 2020, development inequality still occurs in Maluku Province.
Solusi Numerik Model Sir Dengan Menggunakan Metode Runge-Kutta Orde Empat Dalam Prediksi Penyebaran Virus Covid-19 Di Provinsi Maluku
Authors: Rijoly Monalisa , Muin Rizki F. , Rumlawang Francis Y. , Tomasouw Berny Pebo
Published: August 2023

Penelitian ini bertujuan untuk memprediksi penyebaran virus Covid-19 di Provinsi Maluku menggunakan metode Runge-Kutta orde empat. Model matematika penyebaran virus Covid-19 berbentuk sistem persamaan diferensial yang mencakup variabel Susceptible (S) yaitu populasi manusia yang rentan terinveksi virus Covid-19, Infectious (I) yaitu populasi manusia yang telah terinveksi virus Covid-19 dan Recovered (R) yaitu populasi manusia yang sudah sembuh atau yang sudah kebal terhadap virus Covid-19, yang digunakan sebagai nilai awal. Nilai  sebagai nilai parameter yang diselesaikan secara numerik menggunakan metode Runge-Kutta orde empat yang dilakukan sebanyak 20 iterasi dengan waktu interval  bulan menggunakan data dari Dinas Kesehatan Provinsi Maluku dan Polda Maluku tahun 2020 sampai 2021. Berdasarkan data yang diperoleh maka nilai rata-rata dari data tersebut yang digunakan sebagai nilai awal dimana , , . Nilai awal dan nilai parameter disubstitusikan kedalam solusi numerik dan disimulasikan menggunakan dan Matlab sebagai alat bantu. Nilai laju setiap kelas untuk 20 bulan kedepan yaitu untuk laju kelas individu rentan (S) sebesar 69.270 jiwa, untuk laju kelas individu terinfeksi (I) sebesar 19.167 jiwa dan untuk laju kelas individu sembuh (R) sebesar 851 jiwa. Ini berarti bahwa untuk populasi (S) dan (I) akan mengalami penurunan untuk 20 bulan kedepan sedangkan untuk populasi (R) akan mengalami kenaikan pada 20 bulan kedepan.
HASIL TANGKAPAN BENIH BENING LOBSTER (Panulirus spp.) PADA KEDALAMAN ALAT TANGKAP POCONG YANG BERBEDA DI PERAIRAN PRIGI KABUPATEN TRENGGALEK, JAWA TIMUR
Authors: Kristian kusuma wijaya Dani , Subagio Hari , Arief Sofijanto Mochamad , Rosana Nurul
Published: August 2023

Pantai Prigi merupakan salah satu pantai yang terletak di Kecamatan Watulimo, Kabupaten Trenggalek, Jawa Timur. Masyarakat sekitar Pantai prigi umumnya berprofesi sebagai nelayan penangkapan benih bening lobster menggunakan alat tangkap pocong. Penelitian ini bertujuan untuk melakukan kajian pengaruh kedalaman alat tangkap pocong terhadap hasil tangkapan dan komposisi benih bening lobster bedasarkan jenisnya di perairan Prigi. Metode penelitian menggunakan metode eksperimen. Penelitian dilakukan pada saat malam hari, penelitan menggunakan 1 rakit menetap, terpasang 2 alat tangkap pocong benih bening lobster sesuai dengan perlakuan. Posisi alat tangkap pocong 5 m dari permukaan perairan (A1) dan posisi alat tangkap pocong 5 m dari dasar perairan. Pengumpulan data dilakukan dengan cara observasi secara langsung dengan mengikuti kegiatan penangkapan benih bening lobster. Data pendukung tentang suhu permukaan laut, salinitas, kecerahan, arus, dan pH perairan. Berdasarkan data hasil penelitian selanjutnya dilakukan analisa data dengan uji-t menggunakan program pengolahan data SPSS, selain itu dilakukan juga analisa deskriptif terhadap hasil tangkapan pada level kedalaman yang berbeda. Komposisi hasil tangkapan di dapatkan sebanyak 4 jenis benih bening lobster dari 2 perlakuan diantaranya lobster Pasir (Panulirus homarus) 138 ekor (59%), lobster Mutiara (Panulirus ornatus) 67 ekor (29%), lobster Bambu (Panulirus versicolor) 27 ekor (11%), lobster Batu (Panulirus panucillatus) 3 ekor (1$%). Total hasil tangkapan dari A1 dan A2 (235 ekor, 100%). Hasil analisa data paired sample test menggunakan program SPSS di dapatkan bahwa nilai Sig (2-tailed) sebesar 0,003 < 0,05 berarti terdapat perbedaan secara sangat nyata perlakuan A1 dan A2 terhadap hasil tangkapan benih bening lobster.
Effect of Systemic Administration of CD4+ T cells and Local Administration of T-cell Stimulants on T-cell Activity in Psoriatic Skin Xenografts on NOG Mice
Authors: Christensen Pernille KF , Hansen Axel K , Skov Søren , Larsen Jesper , Høyer-Hansen Maria H , Koch Janne
Published: August 2023

Immunodeficient mice engrafted with psoriatic human skin are widely used for the preclinical evaluation of new drug candidates. However, the T-cell activity, including the IL23/IL17 pathway, declines in the graft over time after engraftment, which likely affects the study data. Here,
we investigated whether the T-cell activity could be sustained in xenografted psoriatic skin by local stimulation of T cells or systemic injection of autologous CD4 + T cells. We surgically transplanted human psoriatic skin from 5 untreated patients onto female NOG mice. Six days after surgery,
mice received an intraperitoneal injection of autologous human CD4+ T cells, a subcutaneous injection under the grafts of a T-cell stimulation cocktail consisting of recombinant human IL2, human IL23, antihuman CD3, and antihuman CD28, or saline. Mice were euthanized 21 d after
surgery and spleens and graft biopsies were collected for analysis. Human T cells were present in the grafts, and 60% of the grafts maintained the psoriatic phenotype. However, neither local T-cell stimulation nor systemic injection of autologous CD4+ T cells affected the protein
levels of human IL17A, IL22, IFN γ, and TNF α in the grafts. In conclusion, NOG mice seem to accept psoriatic skin grafts, but the 2 approaches studied here did not affect human T-cell activity in the grafts. Therefore, NOG mice do not appear in this regard to be superior to other
immunodeficient mice used for psoriasis xenografts.
The Nostalgic Home in E. M. Forster's Novels
Authors: Salim Nessma
Published: August 2023

Edward Morgan Forster wrote 6 novels, all of which revolve around the concept of home in relation to the representation of time and its impact on human soul and spirit. Homes of Forster are created by people and their emotions; hence they are very effective in their lives. In his Aspects of the Novel, Forster confirms that the art of fiction depends on facets like characters, plots, patterns, time, and places. This paper handles the representation of homes and the impact of time on these homes in E.M. Forester's Where Angels Fear to Tread, A Room With A View and Howard's End. In these novels Forster uses a recurrent theme; that is the impact of time on places and people. As Angels Fear to Tread echoes Alexander Pope's line in his An Essay on Criticism: "for fools rush in where angels fear to tread", the novel deals with concepts like national character, connection across social differences, the passage of time and its impact on places and houses. In A Room with A View, Forster contrasts Florence, Italy and Windy Corner, England, showing their influence on the development of Lucy, the heroine. Lucy is torn between two different lives. She misses the feeling of home, warmth and domesticity. She struggles throughout the whole novel to embrace love, security, and belonging. Home as a concept is an evasive axis in Forster's Howard's End. The novel is set in the Victorian era where all houses were rebuilt, reconstructed and replaced. There was a demanding rebuilding initiative across Britain, especially in London. That's why houses and places were obviously an entity for people's emotional values. In Howard's End, the Schlegels are evicted from Wickham place, and this leads to their dichotomy. The concepts of places, dwelling, passing of time, and nostalgia, give an opportunity for readers to observe the importance of home in modern life. In Forster's novels, homes are experienced on many levels: homes as places people have already visited and lived in; homes as places people imagined through pictures or dreams; and homes that are never visited or even imagined by dwellers. As John Edward Hardy states: "buildings, and the design of them, the architectural character of civilization, would seem to be in Forster's mind fundamentally related to its character of manners and morals", it would be significant to have a deeper look into the concept of home, time and nostalgia in relation to modern man. Keywords: houses, homes, Forster's novels, passage of time, nostalgia and modernity
Active Ingredients of Schisandra chinensis Fruit Oil and their Effect on Propionibacterium acnes-Induced Inflammation in HaCaT Cells
Authors: Lv Pingping , Zhang Huirong , Tai Meiling , Che Biao , Yu Dan , Zhang Ying , Li Haodong , Meng Xianyao , Guo Miaomiao , Li Li
Published: August 2023

Background: Propionibacterium acnes causes upregulation of inflammatory factors, such as cycloxygenase-2, prostaglandin E2, interleukin-1β, and tumor necrosis factor-alpha, increased levels of reactive oxygen species (ROS) and inward flow of calcium ions. This causes increased levels of the antimicrobial peptide LL-37 and inflammation of the skin, leading to redness, swelling, itching and other symptoms. Schisandra chinensis fruit oil (SCO) is rich in lignan active ingredients with various antioxidant and anti-inflammatory properties. Methods: In this study, SCO is obtained by supercritical CO2 fluid extraction. SCO’s anti-inflammatory actions were investigated using P. acnes-induced inflammation HaCaT cells model. A method based on reversed-phase high-pressure liquid chromatography with a diode array detector was developed and validated for the simultaneous detection of five lignan components. Levels of inflammatory factors and LL-37 were measured by ELISA kit and western blot respectively. Ca2+ and ROS levels detected by flow cytometry. Results: The experimental results show that the contents of schisanol A, schisanol B, schisanin A, schisanin B, and schisanin C were 33.89 ± 0.24, 14.89 ± 0.45, 8.92 ± 0.02, 29.14 ± 0.67, and 4.74 ± 0.09 mg/g, respectively. Studies have demonstrated that SCO can alleviate skin inflammation by inhibiting the COX-2/PGE2 and NF-κB signalling pathway. In addition, SCO can inhibit ROS production, significantly block inward Ca2+ flow, alleviate cell damage, and modulate the content of the antimicrobial peptide LL-37. Conclusions: In summary, our study elucidated the anti-inflammatory activity of SCO in a cell model and provided a scientific basis for its application as a raw material in skin care.
PLEKHA4 is Associated with Tumour Microenvironment, Stemness, Proliferation and Poor Prognosis of Gliomas
Authors: Gao Xin , Liu Yukun , Hong Shunming , Yang Hui , Guan Bing , Ma Xiaodong
Published: August 2023

Background: Glioma is the most common intracranial malignancy. Immune-infiltration and tumour stemness are associated with the prognosis of glioma. Although pleckstrin homology containing family A, number 4 (PLEKHA4) is widely expressed in various human cancers, its role in glioma remains unclear. Methods: We examined the features and clinical significance of PLEKHA4 in gliomas by analysing relevant data from the Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA) databases. Gene set enrichment analysis (GSEA) was performed to determine the possible functions and pathways involving PLEKHA4 in glioma. The relationship between PLEKHA4 expression and the degree of oncogenic dedifferentiation was analysed using stemness scores (ss) calculated from epigenetic and transcriptomic features. We also explored the relationship between PLEKHA4 expression and immune cell infiltration in gliomas using the CIBERSORT databases. Furthermore, drug sensitivity analysis was performed using datasets from the GDSC and GTRP databases. In addition, we performed relevant in vitro experimental studies. Results: PLEKHA4 DNA hypomethylation status was associated with its high expression in glioma tissues as well as poor prognoses. Univariate and multivariate Cox analyses indicated that PLEKHA4 expression may be considered as an independent prognostic factor in patients with glioma. GSEA indicated that high PLEKHA4 expression was associated with Janus kinase (JAK)/signal transducer and activator of transcription (STAT), Wingless-Type MMTV Integration Site Family (Wnt), JUN N-terminal kinase (JNK) signalling pathways and involved in apoptotic, cytoskeletal, and cell adhesion biological processes (BPs). In addition, increased PLEKHA4 expression was associated with higher glioma stemness scores than lower PLEKHA4 expression levels. Furthermore, the expression of PLEKHA4 was shown to be associated with glioma infiltration by CD4+ T cells, B cells, neutrophils, macrophages, and dendritic cells. Drug sensitivity analysis also showed that PLEKHA4 expression was negatively correlated with the sensitivity of several small molecule kinase inhibitors. Furthermore, in vitro experiments confirmed that PLEKHA4 knockdown inhibited the proliferation of glioma cells. Conclusions: PLEKHA4 is highly expressed in glioma tissues and correlated with tumour stemness, immune cell infiltration and proliferation, suggesting its potential as a novel prognostic biomarker and therapeutic target in glioma.
Magnitude of Pulse Pressure Variation is Associated with Qp:Qs Imbalance during Pediatric Cardiac Surgery: A Two-Center Retrospective Study
Authors: Han Ding , Xie Siyuan , Ouyang Chuan
Published: August 2023

Background: Pulse pressure variation (PPV) is based on heart-lung interaction and its association with the imbalance between pulmonary and systemic blood flow (Qp:Qs) has been understudied. We hypothesized that (1) baseline PPV (after induction of anesthesia) is different in a mixed congenital heart disease population with different Qp:Qs, (2) baseline PPV is different between a pooled group with high Qp:Qs and one with low Qp:Qs, and (3) a systemic-pulmonary shunt procedure results in reduced PPV compared to baseline. Methods: We retrospectively reviewed the medical charts of children who presented to the operating room for cardiac surgery between 2010 and 2018. General patient characteristics, PPV, and other hemodynamic parameters following the induction of general anesthesia were retrieved. Patients were grouped according to the type of congenital heart disease, and whether the Qp:Qs ratio was higher or lower than 1. We also identified patients who received a systemic-pulmonary shunt in order to evaluate changes in PPV. Results: A total of 1253 patients were included in the study. Baseline PPV differed significantly according to the type of congenital heart disease, with atrial septal defect showing the lowest PPV (9.5 ± 5.6%) and tricuspid valve malformation the highest (21.8 ± 14.1%). The high Qp:Qs group (n = 932) had significantly lower PPV compared to the low Qp:Qs group (n = 321; 11.8 ± 5.7% vs. 14.9 ± 7.9%, respectively; p < 0.001). PPV decreased significantly following systemic-pulmonary shunt. Conclusions: PPV was associated with Qp:Qs imbalance in children undergoing general anesthesia for cardiac surgery. A lower PPV was associated with increased Qp:Qs. Clinicians should take this into account when using PPV to evaluate volume status and when conducting clinical trials in a mixed population of patients with congenital heart disease.
Impact of Radial Wall Strain on Serial Changes in Vascular Physiology in Patients with Intermediate Coronary Stenosis
Authors: Chu Jiapeng , Lai Yan , Yan Wenwen , Yao Yian , Lin Hao , Yuan Deqiang , Ping Fan , Zhu Guoqi , Ye Zi , Yao Tongqing , Chen Fei , Liu Xuebo
Published: August 2023

Background: Coronary biomechanical stress contributes to the plaque rupture and subsequent events. This study aimed to investigate the impact of plaque biomechanical stability on the physiological progression of intermediate lesions, as assessed by the radial wall strain (RWS) derived from coronary angiography. Methods: Patients with at least one medically treated intermediate lesion at baseline who underwent follow-up coronary angiography over 6 months were included. The maximal RWS (RWSmax) of the interrogated lesion was calculated from the baseline angiogram. The primary endpoint was to determine the association between baseline RWSmax and the functional progression of coronary lesions, defined as an increase in the lesion-specific △quantitative flow ratio (L-△QFR, calculated as the absolute change in QFR across the lesion) on serial angiograms. Results: Among 175 lesions in 156 patients, 63 lesions showed an increase in L-△QFR during a median follow-up period of 12.4 months. Baseline RWSmax values were significantly higher in lesions with increased L-△QFR than in those with stabilized or decreased L-△QFR (11.8 [10.7, 13.7] vs.10.8 [9.7, 11.7]; p = 0.001). Baseline RWSmax presented an area under the curve of 0.658 (95% confidence interval [CI]: 0.572–0.743, p < 0.001) for the prediction of increased L-△QFR. After full adjustment for clinical and angiographic factors, a high RWSmax (>12) was found to be an independent predictor of functional lesion progression (odds ratio: 2.871, 95% CI: 1.343–6.138, p = 0.007). Conclusions: A high RWSmax calculated from baseline angiograms was independently associated with the subsequent physiological progression in patients with intermediate coronary lesions.
تأثير برنامج ارشادي بالهندسة النفسية في تطوير مهارة التصويب لدى ناديي (الرافدين والديوانية) بكرة اليد للناشئين
Authors: حسن رجاء
Published: August 2023

هدفت الدراسة الى اعداد برنامج ارشادي , فضلاً عن اعداد مقياس الهندسة النفسية لدى لاعبي كرة اليد في (الرافدين والديوانية) الرياضي , كذلك التعرف على أثر البرنامج الارشادي بالهندسة النفسية على مهارة التصويب لدى لاعبي كرة اليد في نادي (الرافدين والديوانية)  الرياضي, و قد استخدمت الباحثة المنهج  التجريبي بأسلوب المجموعات المتكافئة لملائمته لمشكلة البحث, كما اشتمل مجتمع البحث على لاعبي كرة اليد في نادي الرافدين و نادي الديوانية الرياضي للموسم (2022-2023) وبلغ عدد أفراد عينة المجتمع (28) لاعب  لكلا الناديين (الديوانية و الرافدين) , وقد بلغت نسبة العينة (100%) من المجتمع الاصلي , وبلغت عينة التجربة الاستطلاعية (8) لاعباً  خارج عينة البحث, وعدمت الباحثة على اجراء التجانس والتكافؤ على عينة البحث , أما  اهم النتائج فكانت بتفوق المجموعة التجريبية على الضابطة في مقياس الهندسة النفسية لدى لاعبي كرة اليد في اندية محافظة الديوانية , إذ اظهرت نتائج الاختبارات فروقاً بين الاختبارين القبلي والبعدي للمجموعتين (التجريبية – الضابطة ) قيد الدراسة, كما أن البرنامج الارشادي قد اثر في متغيرات قيد الدراسة لدى لاعبي كرة اليد في نادي (الرفدين والديوانية) في محافظة الديوانية.
منهج تدريبي للقدرات التوافقية بأوزان مضافة وأثرها في التوازن العصبي العضلي لمهارة الضرب الساحق بالكرة الطائرة
Authors: محمد منتظر
Published: August 2023

تعد لعبة الكرة الطائرة  في مقدمة المجالات التي لاقت تطوراً في الآونة الأخيرة وقد شمل هذا التطور اغلب الألعاب الرياضية وذلك من خلال زج مختلف العلوم الخاصة في مجال الرياضة ، اذ يرتبط هذا التطور بتطور القدرات البدنية الخاصة للاعبين ولقد تعددت طرق ووسائل التدريب المختلفة من اجل التنافس للحصول على نقاط الفوز ان استخدام الأجهزة في مجال الرياضة والادوات المساعدة مهم في تعليم وتدريب الأداء الخاص بالمهارة وتطوير القدرات البدنية الخاصة ومن هنا تكمن اهمية البحث في معرفة تدريبات القدرات التوافقية وأثرها في التوازن العصبي العضلي لمهارة الضرب الساحق بالكرة الطائرة اذ أن هنالك عدم شعور جيد للاعبين في اتخاذ الوضع الصحيح اثناء أداء المهارة والتي تحتاج الى وسيلة يمكنها التأثير من خلالها على مراحل الأداء الفني الصحيح ان هناك اهتماما بتعلّم المهارات الاساسية وبالقابليات البدنية بشكل عام وقلة التركيز على القدرة التوافقية التي يحتاجها لاعبو الكرة الطائرة في عمليات الهجوم اثناء أداء مهارة الضرب الساحق ، تم تطبيق هذه التدريبات على(6) من لاعبي نادي الصناعة فئة الشباب دون سن 20 سنه وحددت اختبارات البحث بـ(EMG) لبيان التوازن العصبي العضلي واجراء قياس بعض المتغيرات الخاصة بالنشاط الكهربائي(القمة) للعضلات المستهدفة  (العضلة الدالية و العضلة الثلاثية  للذراع الترايسبس و عضلة calf)، اذ بينت النتائج ان التدريبات المقترحة القدرات التوافقية بأوزان مضافة أدت الى زيادة فاعلية العضلات الارادية وان اداء هذه التدريبات بمقاومات خفيفة قد حقق توافق عالي وانسيابية بين حركات الطرفين العلوي والسفلي بما يخدم الاقتصادية في الحركة.
تحديد المعايير والمستويات لاهم القدرات البدنية كمؤشر لانتقاء لاعبي الخط الخلفي بكرة اليد
Authors: Rashed Omar
Published: August 2023

ان العمل الجاد يؤدي للوصول الى ارقى المستويات في مختلف المجالات ومنها المجال الرياضي في كافة الالعاب الجماعية وخصوصاً كرة اليد من خلال استشمار الطاقات البشرية الذين يمتلكون قدرات وقابليات تؤهلهم لاداء المهاري المطلوب بكرة اليد، وان انتقاء اللاعبين وفق اهم القدرات البدنية وتحديد المعايير والمستويات لهم واعتبارها كمؤشرات انتقاء لاعبي الخط الخلفي المتمثل (صانع الالعاب ولاعبي الساعد الايمن والايسر) من الامور المهمة لتقوية الفريق لما لهم من دور في الاداء المهاري الهجومي والدفاعي، لذا حدد الباحث مشكلة بحثة بوجوب تحديث المعايير والمستويات لاهم القدرات البدنية كمؤشر لانتقاء لاعبي الخط الخلفي بكرة اليد، وهدفت الدراسة على تحديد اهم القدرات البدنية وبناء معايير ومستويات لها كمؤشرات لانتقاء لاعبي الخط الخلفي بكرة اليد، وحدد الباحث مجتمع بحثة بلاعبي الدوري الممتاز بكرة اليد للموسم (2022-2023)، اما عينة البحث فقد اشتملت على (91) لاعباً، واستعمل الباحث المنهج الوصفي بالاسلوب المسحي، ومن ثم جمع البيانات ومعالجتها احصائياً وتوصلت الدراسة الى ان اهم القدرات الخاصة بلاعبي الخط الخلفي كانت ( القوة الانفجارية، والسرعة الانتقالية، وتحمل السرعة، الرشاقة) وتحديد المعايير والمستويات كمؤشرات للانتقاء اللاعبين على ضوء النتائج توصي الدراسة الى استخدام الاختبارات البدنية واعتماد المعايير والمستويات عند انتقاء للاعبي الخط الخلفي بكرة اليد.
Impressive Control of Diabetes type 2 with Chicken Gizzards
Authors: Khan Muhammad Imtiaz
Published: August 2023

My all blood sugar tests are available with my glucose test meter and Dynacare plus laboratory
Sức nặng của đồng tiền “bác ái” cho nghị sự nghiên cứu bảo vệ môi sinh
Authors: Duong Ca Ngu Dai
Published: August 2023

Nghiên cứu của Enrici et al. (2023) trên tạp chí Ecology and Society [1] là một trong số không nhiều những thảo luận kỹ về sức nặng tiền bạc đối với cách con người (bao gồm cả học giới, chính giới và cư dân) hiểu về tác động của con người đối với môi sinh. Rõ ràng, những hiểu biết này rất quan trọng, nhất là khi sự cấp bách đối với tác động của con người lên môi trường đã thực sự gióng lên những hồi chuông báo động, đứng trước các hiểm họa khó lường của khủng hoảng khí hậu.
Teaching self-efficacy in primary education in Greece
Authors: Terzi Elpida
Published: August 2023

This paper deals with teaching self - efficacy in primary education in Greece. The purpose of the research carried out is to investigate the teaching self - efficacy of teachers in primary education in Greece. Specifically, an attempt is made to investigate how primary school teachers evaluate their level of self - efficacy, regarding teaching tasks, managing disciplinary incidents in the classroom and motivating students to be actively involved in the classroom and learning tasks, how the self - efficacy of primary education teachers from their educational experience and studies and what are the possible obstacles to the self - efficacy of these teachers. The research shows that the overall self - efficacy perception of teachers is particularly high with teachers considering themselves to be more effective in managing the classroom and implementing teaching strategies/educational approaches. Also, the self - efficacy of primary school teachers seems to be influenced by their educational experience and studies. Instead, it seems that teachers' overall self - efficacy perception is related to factors such as the stress and pressure they experience, the degree of effectiveness they generally feel as individuals, but also their goals.
Systematic Measurement Error Can be Detected and Quantified by Performing Ordinary Statistical Tests on Item Errors
Authors: Beatty Michael , Siem Faith , Shenouda Steven
Published: August 2023

Self-report measures are ubiquitous in behavioral science and have been a key method used to examine evolutionary hypotheses. Indeed, evidence for the existence and functional boundaries of many psychological adaptations is inferred based on responses on self-report measures. Valid inferences based on self-report data require that questionnaire items measure only the construct they were designed to measure, which in statistical terms means that measurement error is predominately random. In contrast, systematic error indicates that items measure constructs in addition to those the instrument was designed to measure. Substantial systematic error associated with measures used in research risks theoretically consistent interpretations that are, instead, spurious effects of method error. Here, we propose a strategy for estimating the portion of systematic measurement error contained in multi-item self-report measures. This strategy rests on the observation that item-errors can be treated like any other set of scores and therefore have the potential to reveal otherwise unnoticed patterns in the data.
FDPS is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: August 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that farnesyl diphosphate synthase, encoded by FDPS, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. FDPS mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of FDPS in primary tumors was correlated with patient distant metastasis-free and recurrence-free survival. Modulation of FDPS expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
Association of Anticholinergic Burden with Hippocampal Subfields Volume in First-Episode Psychosis
Authors: Belkacem Agnes , Lavigne Katie M. , Raucher-Chéné Delphine , Makowski Carolina , Chakravarty Mallar , Joober Ridha , Malla Ashok K. , Shah Jai , Lepage Martin
Published: August 2023

Polypharmacy is relatively common in early psychosis, but little attention has been paid to the anticholinergic burden of medication use (cumulative effect of medications that block the cholinergic system). Evidence suggests that anticholinergic burden is associated with cognitive deficits and that hippocampal dysfunction may be involved in those impairments. We aimed to examine this association in a cohort of patients with first-episode psychosis. We hypothesized that patients with the highest burden would experience a more significant reduction in hippocampal volume compared to those with low burden and healthy controls, both at baseline (3 months) and at month 12. Patients (n=82; low burden [n=64] and high burden [n=18], defined by a Drug Burden Index cut-off of 1) followed at the PEPP-Montreal clinic, and controls (n=55) completed a 3T MRI at both timepoints. After controlling for antipsychotic dosage at both timepoints, results at baseline and over time revealed a greater reduction in left fimbria volumes in high-burden patients compared to low-burden patients and controls. Overall, the associations observed between high anticholinergic burden and hippocampal volume provide further evidence for considering this dimension when prescribing medication in early psychosis.
DevOps for DataVis: A Survey and Provocation for Teaching Deployment of Data Visualizations
Authors: Adams Jane L.
Published: August 2023

We present a provocation towards teaching development operations (“DevOps") and other infrastructure concepts in the course of collegiate data visualization instruction. We survey 65 syllabi from semester-long, college-level data visualization courses, with an eye toward languages and platforms used, as well as mentions of deployment related terms. Results convey significant variability in language and tooling used in curricula. We identify a distinct lack of discussions around ‘DevOps for DataVis’ scaffolding concepts such as version control, package management, server infrastructure, high-performance computing, and machine learning data pipelines. We acknowledge the challenges of adding supplemental information to already dense curricula, and the expectation that prior or concurrent classes should provide this computer science background. We propose a group community effort to create one free ‘course’ or ‘wiki’ as a living reference on the ways these broader DevOps concepts relate directly to data visualizationspecifically.
Importin 13 is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: August 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that importin 13, encoded by IPO13, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. IPO13 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of IPO13 in primary tumors was correlated with patient distant metastasis-free and recurrence-free survival. Modulation of IPO13 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
Why Radical Movements Collapse and Resurge: Evidence from the U.S. Radical Environmental Movement
Authors: Zeitzoff Thomas
Published: August 2023

Why did the radical environmental movement decline in the mid-2000’s in the U.S? Given the threat posed by global warming, why haven’t we seen the emergence of more intense contentious tactics from the movement? I develop a theory of why radical movements emerge, and why they collapse. I argue that pre-existing activist networks, along with the salience of an organizing threat like climate change, influence the emergence and tactics of radical movements. But repression changes a movement and has both a direct and indirect effect. Arrests and threats of repression can lead activists to exit the movement or change tactics (direct effect). As new activists from different networks enter the movement, they bring their own norms and preferred tactics (indirect effect). To test this theory, I take a mixed methods approach to the U.S. radical environmental movement and provide evidence from: 1) a new dataset of eco direct actions from 1995-2022; 2) novel survey data of the American public, younger Americans, and activists; and 3) semi-structured interviews with past and present activists and experts. The findings show the importance of pre-existing networks as pathways into radical activism. They also show how norms against property destruction, and the response to repression shaped the subsequent trajectory of the movement.
PTPRZ1 is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: August 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that protein tyrosine phosphatase, receptor type Z1, encoded by PTPRZ1, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. PTPRZ1 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of PTPRZ1 in primary tumors was correlated with patient recurrence-free survival. Modulation of PTPRZ1 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
How (not) to talk about plant-based foods: Using language to support the transition to sustainable diets
Authors: Papies Esther K. , Davis Tess , Farrar Stephanie , Sinclair Maddie , Wehbe Lara
Published: August 2023

Reducing meat consumption is essential to curb further climate change and limit the catastrophic environmental degradation resulting from the current global food system. However, consumers in industrialised countries are hesitant to reduce their meat intake, often because they find plant-based foods less appealing. Despite the climate emergency, eating meat is still perceived as the norm, and recommended in most national dietary guidelines. To support the transition to more sustainable diets by providing insights for increasing the appeal of plant-based foods to mainstream consumers, this article reviews recent research findings on how people think and communicate about meat-based and plant-based foods. The key findings we review include: (1) While vegans think about plant-based foods in terms of enjoyable eating experiences, omnivores think about plant-based foods in terms of health, vegan identity, and other abstract information that does not motivate consumption in the moment. (2) Packages of ready-meals and social media posts on Instagram present plant-based foods with fewer references to enjoyable eating experiences than meat-based foods. (3) Presenting plant-based foods with language that references enjoyable eating experiences increases their appeal, especially for habitual meat eaters. This language includes words about sensory features of the food (e.g., crunchy, creamy), eating context (e.g., pub; with family), and immediate positive consequences of eating (e.g., comforting, delicious). In contrast, the term “vegan” is strongly associated with negative stereotypes. Hence, rather than referring to being vegan, meat-free, or healthy, the language used for plant-based foods should refer to sensory appeal, attractive eating situations, and enjoyment.
Time of day perception in paintings
Authors: YU CEHAO , van Zuijlen Mitchell J.P. , Spoiala Cristina , Pont Sylvia C. , Wijntjes Maarten , Hurlbert Anya
Published: August 2023

The spectral shape, irradiance, direction, and diffuseness of daylight vary regularly throughout the day. The variations in illumination and their effect on the light reflected from objects may in turn provide visual information as to the time of day. We suggest that artists’ color choices for paintings of outdoor scenes might convey this information and that therefore the time of day might be decoded from the colors of paintings. Here we investigate whether human viewers’ estimates of depicted time of day in paintings correlate with their image statistics, specifically chromatic and luminance variations. We tested time-of-day perception in 17th-20th century Western European paintings via two online rating experiments. In Experiment 1, viewers’ ratings from 7 time choices varied significantly and largely consistently across paintings, but with some ambiguity between morning and evening depictions. Analysis of the relationship between image statistics and ratings revealed correlations with the perceived time of day: higher “morningness” ratings associated with higher brightness, contrast, saturation, and darker yellow/ brighter blue hues; “eveningness” with lower brightness, contrast, saturation, and darker blue/ brighter yellow hues. Multiple linear regressions of extracted principal components yielded a predictive model that explained 76% of the variance in time-of-day perception. In Experiment 2, viewers rated paintings as morning or evening only; rating distributions differed significantly across paintings; and image statistics predicted people’s perceptions. These results suggest that artists used different color palettes and patterns to depict different times of day, and the human visual system holds consistent assumptions about the variation of natural light depicted in paintings.
Swinging, Fast and Slow: Multiscale Synchronisation Dynamics Reveals the Impact of an Improvisatory Approach to Performance on Music Experience
Authors: Nozawa Takayuki , Sas Madalina I , Dolan David , Rajpal Hardik , Rosas Fernando , Timmermann Christopher , Mediano Pedro A. M. , Honda Keigo , Amano Shunnichi , Miyake Yoshihiro , Jensen Henrik J.
Published: August 2023

Experiences of collective creative activities play an essential role in human societies, yet these experiences are particularly hard to capture, making their scientific scrutiny extremely challenging. Here we investigate the experience of audience members during a musical concert associated with collective improvisation by analysing the audience's subjective reports and movement patterns. Our results show that performance with improvisational elements affect movement synchronisation dynamics between performers and audience members differently at different timescales, which are predictive of changes in the subjective perception of music. These results provide a first step towards the quantification of some of the fundamental aspects of these collective experiences. Moreover, the reported findings shed new light on the relevance of the often-neglected multiscale coordination between audiences and performers, and explains how this rich tapestry of physical behaviour is connected with the quality of the collective subjective experience.