bluuebunny/crossref_metadata_2025 huggingface dataset:
Neural correlates of the attention training technique as used in metacognitive therapy – A randomized sham-controlled fMRI study in healthy volunteers
Authors: Jahn Niklas , Sinke Christopher , Kayali Özlem , Krug Svenja , Leichter Erik , Peschel Stephanie , Müller Torben , Burak Alev , Krüger Tillmann H. C. , Kahl Kai G. , Heitland Ivo
Published: March 2023

Introduction

The Attention Training Technique (ATT) developed as part of metacognitive therapy is a psychotherapeutic treatment method used to enhance top-down attentional flexibility and control. This study investigated potential neurocognitive changes due to ATT and its underlying neural mechanisms using pre-to-post functional magnetic resonance imaging (fMRI).

Materials and methods

Fifty-four healthy participants were subjected to a randomized, sham-controlled attention training and evaluated using a neurocognitive test battery that partly took place in an fMRI environment. Participants received two doses ATT or sham ATT daily for 1 week. On day eight, all subjects completed the neurocognitive test battery again.

Results

After the training, the ATT group showed a significant improvement in reaction times regarding attentional disengagement compared to the sham ATT group. fMRI data showed decreased levels of activation in the anterior cingulate cortex (ACC) when comparing the ATT group to the sham ATT group during attentional disengagement post intervention. No ATT > sham ATT effects were found regarding selective auditory attention, working memory performance and inhibitory control.

Discussion

These findings putatively indicate that ATT facilitates faster attention allocation and increased attentional flexibility in healthy subjects. The fMRI results suggest this ATT-dependent improvement is accompanied by reduced ACC activity, indicating a more flexible attentional state.
Dual mediating effects of social support and fertility stress on mindfulness and fertility quality of life in infertile men: A case-control study
Authors: Abulizi Maierhaba , Xu Hua , Abuduguli Alapate , Zhao Wanzhu , He Lijuan , Zhang Chen
Published: March 2023

Background

Infertility is one of the three major public health problems in the world, bringing immense physical and psychological damage to men and affecting the quality of men’s fertility life. Thus, the purpose of this study was to analyze the status of social support, fertility stress, mindfulness, and fertility quality of life in infertile men, and to explore the dual mediating effects of social support and fertility stress on mindfulness and fertility quality.

Methods

A case–control group study was conducted, with 246 men in the case group and 149 in the control group. The Social Support Scale, Fertility Stress Scale, Mindfulness Scale, and Fertility Quality of Life Scale were used to establish a structural equation model using Mplus 8.3 to explore social support and fertility stress. Pathway relationships were drawn between mindfulness and fertility quality of life in infertile men.

Results

There were significant differences between infertile and healthy men in each dimension of the core module of fertility quality of life, in the total score of the treatment module, in the total score of social support, in subjective and objective support, and in the total score of fertility stress, social pressure, sexual pressure, marital relationship, and childless pressure (p < 0.05 in each case). Further, the fertility quality of life in infertile men was positively correlated with mindfulness and social support, and negatively correlated with fertility stress (p < 0.05); mindfulness could directly affect the core and treatment modules of fertility life quality, and indirectly affect the core of fertility life quality through social support (mediation effect accounted for 19.0%), while the treatment module (mediation effect accounted for 13.7%), and the core module indirectly affected fertility life quality through fertility stress (mediation effect accounted for 16.8%).

Conclusion

The fertility quality of life of infertile men is not optimistic. Mindfulness-related interventions and programs can improve their fertility quality of life.
A feasibility study of psychological first aid as a supportive intervention among police officers exposed to traumatic events
Authors: Geoffrion Steve , Leduc Marie-Pierre , Bourgouin Elody , Bellemare François , Arenzon Valérie , Genest Christine
Published: March 2023

Introduction

Police officers are often exposed to traumatic events, which can induce psychological distress and increase the risk of developing post-traumatic stress injuries. To date, little is known about support and prevention of traumatic events in police organizations. Psychological first aid (PFA) has been promoted as a promising solution to prevent psychological distress following exposure to a traumatic event. However, PFA has not yet been adapted to policing reality, let alone to the frequent exposure to traumatic events faced by this population. This study aimed to evaluate the feasibility of PFA as an early intervention for the prevention of post-traumatic stress injuries among police officers in Quebec, Canada. Specifically, the objectives were to evaluate: (1) the demand. (2) the practicality, and (3) the acceptability of PFA in a police organization.

Methods

A feasibility study was conducted to evaluate the implementation of PFA among Quebec’s provincial police force. To do so, 36 police officers participated in semi-structured interviews between October 26th, 2021, and July 23rd, 2022. Participants were comprised of responders (n = 26), beneficiaries (n = 4) and managers (n = 6). Interviews were transcribed, coded, and evaluated according to a thematic analysis.

Results

Eleven themes emerged from participants’ responses. Results suggested that PFA met individual and organizational needs. References were also made regarding the impacts of this intervention. Moreover, participants provided feedback for improving the implementation and sustainability of a PFA program. All three groups of participants shared similar thematic content.

Discussion

Findings revealed that implementation of a PFA program in a law enforcement agency was feasible and could be accomplished without major issues. Importantly, PFA had beneficial consequences within the organization. Specifically, PFA destigmatized mental health issues and renewed a sense of hope among police personnel. These findings are in line with previous research.
The efficacy of mindfulness-based therapy for anxiety, social skills, and aggressive behaviors in children and young people with Autism Spectrum Disorder: A systematic review
Authors: Loftus Tundi , Mathersul Danielle C. , Ooi Michelle , Yau Shu H.
Published: March 2023

Introduction

The purpose of this systematic review was to examine the efficacy of mindfulness-based interventions for improving anxiety, social skills, and aggressive behaviors in children and young people (CYP) with Autism Spectrum Disorder (ASD); summarize the results across clinic, home, and school contexts; and evaluate the quality of these interventions for clinical practice.

Methods

A search of the PsycINFO, Medline (Ovid), Web of Science, and Scopus databases was conducted in June 2021, and no date restrictions were applied. Inclusion criteria were quantitative or qualitative research implementing a mindfulness-based intervention for CYP aged 6–25 years with a diagnosis of ASD, Pervasive Development Disorder, or Asperger’s Syndrome.

Results

We identified 23 articles for inclusion including within subject pre- and post-testing, multiple baselines, and randomized control trials, among other research designs. Of these, a quality analysis conducted using an ASD research-specific risk of bias tool found over half (14) were of weak methodological quality, whereas only four and five were found to be of strong and adequate quality, respectively.

Discussion

While the results of this systematic review suggest promising evidence for the use of mindfulness-based interventions to improve anxiety, social skills, and aggressive behaviors in CYP with ASD, results should be interpreted with caution due to the limitations resulting from the overall weak quality of the studies.

The review protocol was pre-registered on PROSPERO (CRD42021259125) and can be viewed at https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=259125
Validation of sociocultural attitudes towards appearance questionnaire and its associations with body-related outcomes and eating disorders among Chinese adolescents
Authors: Huang Houyi , Liu Zhongting , Xiong Haoran , Herold Fabian , Kuang Jin , Chen Erle , Taylor Alyx , Yeung Albert , Sun Jing , Hossain Md M. , Kramer Arthur , Guo Tianyou , Zou Liye
Published: March 2023

Introduction

The Sociocultural Attitudes Towards Appearance Questionnaire-4 Revised (SATAQ-4R) has been widely used in Western countries to link body appearance that is related to eating disorders and body dissatisfaction being commonly reported by adolescents. However, a comprehensive psychometric validation of the SATAQ-4R in Chinese adolescent samples is still lacking. To this end, the aim of the current study was to validate the gender-appropriate SATAQ-4R in a sample of Chinese adolescents, following by an investigation of its associations with body-related outcomes and eating disorder symptoms.

Methods

Two gender-specific studies were conducted to examine the psychometric properties of the SATAQ-4R-Female and SATAQ-4R-Male respectively among adolescent girls (Study1, N=344, with 73 participants at retest) and boys (Study2, N=335, with 64 participants at retest). Confirmatory factor analysis was employed to examine the factor structure and their test-retest reliability, the internal consistency and convergent validity were subsequently examined.

Results

For the SATAQ-4R-Females, the seven-factor model has a reasonable fit, with Chi-square =1112.769 (p < 0.001), CFI = 0.91, RMSEA = 0.071, SRMR = 0.067. For the SATAR-4R-Males, an acceptable seven-factor model with Chi-square = 982.92 (p<0.001), CFI = 0.91, RMSEA = 0.08, SRMR= 0.06 was observed. With respect to test-retest reliability, the internal consistency for 7 subscales was rated as good (Cronbach’s alpha =0.74 to 0.95) among female adolescents, likewise the internal consistency of the seven subscales was also rated as good (Cronbach’s alpha =0.70 to 0.96) among male participants. Good convergent validity was observed, reflected by associations of the subscales of the gender-specific SATAQ-4R with muscularity-related attitude, body image-acceptance, body appearance, perceived stress level, symptoms of eating disorder and self-esteem.

Discussion

For women and men, the original 7-factor structure was validated among Chinese adolescents, internal reliability coefficients for the seven subscale scores were good and test-retest reliability was acceptable. Our results also confirmed the convergent validity of the two different gender-appropriate scales.
Emotional distress and burnout at a fever clinic in China: Comparison between different periods of COVID-19
Authors: Geng Wenqi , Cao Jinya , Hong Xia , Jiang Jing , Hu Jiaojiao , Duan Yanping , Wei Jing
Published: March 2023

Background

Frontline healthcare workers (FHWs) experienced psychological stress and heavy workload during COVID-19 pandemic. This study examined the psychological symptoms and occupational burnout of FHWs in a fever clinic during different periods of the pandemic.

Methods

A cross-sectional survey of FHWs in the fever clinic of a tertiary hospital was carried out during both the outbreak period and regular period of COVID-19. Psychological measurement instruments including Generalized Anxiety Disorder 7-item, the 9-Question Patient Health Questionnaire, the Maslach Burnout Inventory-Human Service Survey, and the General Self-Efficacy Scale were used to evaluate anxiety, depression, burnout, and self-efficacy, respectively. The correlation between clinical variables was explored.

Results

A total of 162 participants were involved in this study, including 118 FHWs during the outbreak period (Group 1) and 44 FHWs during the regular period (Group 2). Anxiety symptoms were more prevalent in Group 2 (x2 = 27.477) while depressive symptoms were significantly more prevalent in Group 1 (x2 = 69.538). Burnout rate was higher in Group 2 (x2 = 29.526). Self-efficacy was higher in Group 1 (t = 3.194). Burnout was positively correlated with anxiety symptoms (r2 = 0.424) and negatively correlated with self-efficacy (r2 = −0.312).

Conclusion

Anxiety, depressive symptoms and burnout were prevalent in FHWs during different periods of the COVID-19 pandemic. There is a tendency to be less depressed, but more anxious and burned out over time, although the severity of the pandemic is decreasing. Self-efficacy may be an important factor in protecting FHWs from occupational burnout. Support and intervention plans for FHWs should be made at the institutional level.
Prevalence and correlates of elder neglect in the community-dwelling Chinese population: New evidence from the CLHLS study
Authors: Fu Yi-cheng , Pei Min-yue , Liao Jiao-jiao , Li Nan , Zhang Fu-chun , Liu Hui-lin
Published: March 2023

Background

This study aimed to explore the prevalence of elder neglect (EN) and its associated factors among community-based Chinese older adults.

Methods

We used data from the 2018 phase of a nationwide cross-sectional study, the Chinese Longitudinal Healthy Longevity Survey (CLHLS), which recruited 15,854 older adults to complete the study interviews that incorporated six dimensions of EN, namely, life neglect, social isolation, medical neglect, poor living situation, family neglect, and social neglect. Multivariate logistic regression was used to explore factors associated with EN.

Results

We included demographic factors, chronic diseases, cognitive function, and daily activity function in our comprehensive analysis and showed that they had different effects on the six EN dimensions. Different demographic factors such as gender, age, marriage, education, occupation, residence, and household income were included in the comprehensive analysis, and the results showed that these factors had different effects on the six dimensions of EN. Next, we found that older adults with chronic diseases are prone to life neglect, medical neglect, and residential environment neglect. Older adults with better cognitive abilities were less likely to be neglected, and a decline in daily activity capacity has been linked to EN in older adults.

Conclusion

Future studies are needed to identify the health effects of these associated factors, develop prevention strategies for EN, and improve the quality of life of older adults living in communities.
Listen to the science! Which science? Regenerative research for times of planetary crises
Authors: Raffoul Alexandre Wadih
Published: March 2023

In situations where scientists disagree, which science should decision-makers listen to? This article argues that we should listen to “regenerative research”, that is, research (1) whose objective is to regenerate our relationship to the land and to each other (rather than dominating nature), (2) whose worldview acknowledges the interconnection between humans and non-humans (rather than assuming a separation between humanity and nature), and (3) whose processes are democratized (instead of including but a narrow circle of researchers). We should listen to regenerative science not because it is suited to the interests of politicians or activists, but because it is most likely to be beneficent, rigorous, and objective. In addition to granting scientists new responsibilities, such as engaging in public action, the climate and ecological crises therefore also require us to critically reflect on the core of our work: the knowledge we generate.
Anesthesia, pain management and surgical approach of ovariectomy or orchiectomy in six Egyptian fruit bats (Rousettus aegyptiacus): A case report
Authors: Tal Smadar , Shilo-Benjamini Yael
Published: March 2023

The purpose of this report is to describe the anesthetic and analgesic management and the surgical procedures of gonadectomy in six (four females and two males) healthy adult Egyptian fruit bats (Rousettus aegyptiacus). Bats were anesthetized with a combination of alfaxalone, midazolam, and morphine administered subcutaneously. Incisional line infiltration using bupivacaine was administered in all bats, and additional bilateral intratesticular injection was administered in the males. Ovariectomy was performed via a dorsal approach, by bilateral midline skin incisions at the paralumbar fossa level. Orchiectomy was performed via a ventral approach, by bilateral midline incisions of scrotal skin above the testes. Following surgery, all bats were administered flumazenil for midazolam reversal, and meloxicam for postoperative analgesia, subcutaneously. All bats recovered from anesthesia uneventfully. Bats were monitored for complications up to 10 days following surgery, when skin sutures were removed. No morbidities or mortalities occurred during this period in any of the bats. In conclusion, ventral approach orchiectomy and dorsal approach ovariectomy using the injectable combination alfaxalone-midazolam-morphine in conjunction with local anesthesia and meloxicam are feasible procedures in Egyptian fruit bats and can be performed with relative ease. However, further studies using these techniques in a larger group of bats should be performed to establish their safety.
Between Care and Coercion: Asylum Seekers’ Experiences With COVID-19 Containment and Mitigation Measures in German Reception Centres
Authors: Rast Eilin , Perplies Clara , Biddle Louise , Bozorgmehr Kayvan
Published: March 2023

Objectives: COVID-19 containment and mitigation measures have been criticised for amplifying pre-existing individual and structural vulnerabilities among asylum seekers. We qualitatively explored their experiences with and attitudes towards pandemic measures to inform people-centred responses in future health emergencies.

Methods: We interviewed eleven asylum seekers in a German reception centre (July-December 2020). The semi-structured interviews were recorded, transcribed, and analysed thematically with an inductive-deductive approach.

Results: Quarantine was experienced as burdensome by participants. Shortcomings in social support, everyday necessities, information, hygiene, and daily activities exacerbated the strains of quarantine. Interviewees held different opinions about the usefulness and appropriateness of the various containment and mitigation measures. These opinions differed by individual risk perception and the measures’ comprehensibility and compatibility with personal needs. Power asymmetries related to the asylum system furthermore impacted on preventive behaviour.

Conclusion: Quarantine can amplify mental health burdens and power asymmetries and can therefore constitute a considerable stressor for asylum seekers. Provision of diversity-sensitive information, daily necessities, and accessible psychosocial support is required to counteract adverse psychosocial impacts of pandemic measures and safeguard wellbeing in this population.
A Review of Detection Technologies for Underwater Cracks on Concrete Dam Surfaces
Authors: Chen Dong , Huang Ben , Kang Fei
Published: March 2023

Cracks seriously endanger the safe and stable operation of dams. It is important to detect surface cracks in a timely and accurate manner to ensure the safety and serviceability of a dam. The above-water crack detection technology of dams has been widely studied, but due to the complex underwater environment, above-water crack detection technology on dam surfaces cannot be directly applied to underwater crack detection. To adapt to the underwater detection environment and improve the efficiency and accuracy of underwater crack detection, many methods have been proposed for underwater crack detection, including sensor detection and image detection. This paper presents a systematic overview of the development and application practices of existing underwater crack detection technologies for concrete dams, focusing on methods that use underwater robots as underwater mobile carriers to acquire images that are combined with digital image processing algorithms to identify, locate, and quantify underwater cracks in dams. This method has been widely used for underwater crack detection on dam surfaces with the advantages of being non-contact, non-destructive, having high efficiency, and wide applicability. Finally, this paper looks further forward to the development trends and research challenges of detection technologies for underwater cracks on concrete dam surfaces, which will help researchers to complete further studies on underwater crack detection.
Dynamic Response Analysis of Buried HDPE Pipes under Vibration Compaction Considering the Influence of Buried Depth and Filling Modulus
Authors: Ma Chongqian , Wang Xuan , Zhang Jiasheng , Luo Hao , Zhang Yu
Published: March 2023

During pavement construction, the gravity load and vibration excitation from vibratory rollers can seriously affect the safety of underground pipelines. However, research on the dynamic response of buried pipelines under the action of large vibration rollers is rarely reported. Therefore, the dynamic response of a high-density polyethylene (HDPE) double-wall corrugated pipe under a vibratory roller was studied via field testing and a three-dimensional nonlinear finite-element model was established. This model was used to analyze the influence of filling property and vibration frequency on the dynamic response of an HDPE pipe under a vibration load from a vibratory roller. The results reveal that with the increase of compaction times, the backfill soil keeps changing between over-compaction (loose) and compaction states, and the pipe top pressure also keeps changing. Moreover, at a shallow burial, the pipe top pressure is more obvious when the compaction degree changes. The elastic modulus of filling soil within a certain range can effectively reduce the stress deformation of the pipeline under vibration compaction. However, when the elastic modulus of filling soil exceeds 10 times the initial elastic modulus, the deformation of the pipeline becomes greater than the initial value.
Design and Performance Research of a Wearable Airbag for the Human Body
Authors: Zhang Xuerong , Xue Zhixiang , Tu Wenqiong
Published: March 2023

In this paper, an integrated wearable airbag is proposed to protect the vulnerable pedestrian during a vehicle–pedestrian collision accident. To evaluate the protection performance of this newly proposed integrated wearable airbag, the airbag inflator finite element model is first verified via an inflator tank test, and the simulated results agree very well with the test. Next, the finite element model of the vehicle–pedestrian model is established, including a simplified vehicle model and a biomechanical HBM with the integrated wearable airbag. The numerical results show the newly proposed wearable airbag can effectively protect the pedestrian by significantly reducing injuries to the head and chest. Since head injury is the most important injury type, a complete set of injury indexes is adopted to evaluate severity of head injury, including HIC15, 3 ms resultant acceleration, and intracranial pressure. To further improve the protection performance of the airbag on the HBM’s head, a parametric study is conducted towards two design parameters of the wearable airbag: inflator gas mass and pulling strap length. The parametric investigation shows 26 g gas and a 20 mm pulling strap can provide the best protection for the HBM’s head.
Impacts of Pollutant Emissions from Typical Petrochemical Enterprises on Air Quality in the North China Plain
Authors: Zhang Ziyue , Yang Wenyu , Zhang Shucai , Chen Long
Published: March 2023

Under the state’s key surveillance, petrochemical industries are considered polluting enterprises. Even though large-scale petrochemical enterprises follow the complete treatment of combustion waste gas, process waste gas, and volatile organic waste gas pollutants, the impact of pollutant emissions on the regional air quality is unclear. This study used the atmospheric chemical transport model and adopted the subtraction method to simulate the impacts of air pollutant emissions from four typical petrochemical enterprises on regional air quality of the North China Plain. Results indicated that emissions from petrochemical enterprises on surface PM2.5, SO2, and NO2 concentrations mainly contributed to the nearby area, particularly SO2 and NO2. The pollution can be controlled within the boundaries of the petrochemical plants. Petrochemical enterprises had a small SO2 and NO2 contribution with a maximum of up to 4.65% within a 9 km distance. Emissions from petrochemical enterprises contributed less to surface PM2.5 concentrations (less than 0.5%) within a 9 km distance. Surface O3 concentrations driven by petrochemical enterprises did not show near-source distribution characteristics, which were closely related to its complex precursors and secondary reactions. Contributions of petrochemical enterprises to local pollution decreased significantly with the increase in distance. The SO2 and NO2 pollution contributions to the North China Plain remained around 0.1–0.2%, with the maximum contribution occurring in January and July. The maximum contribution of PM2.5 in this region was in April (0.42%) while it was below 0.1% for other months. The pollutant emission from the four typical petrochemical enterprises in the North China Plain had little impact on the concentration of air pollutants in the North China Plain. However, it had a significant impact on the ambient air quality in the region near the enterprise. This study can be useful in analyzing and refining the influence of enterprises on the region.
Seasonality of Relationship between Tropical Cyclone Frequency over the Southern Hemisphere and Tropical Climate Modes
Authors: Ogata Tomomichi
Published: March 2023

In this study, the author examined the tropical cyclone (TC) activity over the southern hemisphere (SH) and its relationship with tropical climate modes, such as the El Niño–Southern Oscillation (ENSO), during the austral summer (December–January–February; DJF) and fall (March–April–May; MAM). The correlation analysis between the TC activity and the global sea surface temperature (SST) suggested that an increased TC activity over the southwestern and southeastern Indian Ocean (SWIO and SEIO) was associated with a La Niña-like SST pattern, while an increased TC activity over the southwestern Pacific (SWP) was associated with an El Niño-like SST pattern. The atmospheric conditions accompanying the TC increase over the SWIO/SEIO indicated that a La Niña induces tropospheric cooling over the tropics with cyclonic circulation anomalies over the TC genesis region. Both the SST anomalies and the cyclonic circulation anomalies were significantly correlated with TC genesis parameters, suggesting that they contributed to TC genesis. To investigate the SST precursors, a lead-lag correlation analysis was performed. For the TC variations over the SEIO, an SST pattern that resembled the Pacific Meridional Mode (PMM) was statistically significant at a two-season lead. However, such a TC-ENSO relationship is seasonally dependent, with different patterns during DJF and MAM. These results suggest that the Matsuno-Gill response to ENSO is an important factor in TC activity but that this influence is seasonally modulated over the SH.
Neural Correlates of Antisocial Behavior: The Victim’s Perspective
Authors: Trevisan Nicolò , Cattarinussi Giulia , Olivo Daniele , Di Ciano Andrea , Giudetti Lucia , Pampallona Alan , Kubera Katharina M. , Hirjak Dusan , Wolf Robert Christian , Sambataro Fabio
Published: March 2023

Antisocial behavior involves actions that disregard the basic rights of others and may represent a threat to the social system. The neural processes associated with being subject to antisocial behavior, including social victimization, are still unknown. In this study, we used a social interaction task during functional magnetic resonance imaging to investigate the neural bases of social victimization. Brain activation and functional connectivity (FC) were estimated and correlated with the Big 5 Questionnaire, Temperament Evaluation in Memphis, Pisa and San Diego (TEMPS-M), and a Questionnaire of Daily Frustration scores. During social victimization, the right occipital and temporal cortex showed increased activation. The temporal cortex also had reduced FC with homotopic areas. Compared to the prosocial interaction, social victimization showed hyperactivation of the dorsomedial and lateral prefrontal cortex, putamen, and thalamus and increased FC of the medial-frontal–striatal–thalamic areas with the ventrolateral prefrontal cortex, insula, dorsal cingulate, and postcentral gyrus. Lastly, neuroticism, irritable temperament, and frustration scores were correlated with the magnitude of neural responses to social victimization. Our findings suggest that social victimization engages a set of regions associated with salience, emotional processing, and regulation, and these responses can be modulated by temperamental and personality traits.
Telerehabilitation Pathways in Specific Learning Disorders: Improving Reading and Writing
Authors: Capodieci Agnese , Graziani Daniela , Scali Valentina , Giaccherini Susanna , Luccherino Luciano , Pecini Chiara
Published: March 2023

Telerehabilitation has proved to be a useful tool for neurodevelopmental disorders in allowing timely and intensive intervention and preventing relapses; it is also widely used for specific learning disabilities (SLD), showing significant effects on reading abilities, but variables linked to its effectiveness have not been studied yet. The present study was aimed at testing the effectiveness of telerehabilitation on reading and writing in SLD children, comparing different treatment pathways, and considering the impact of training intensity and executive functions. Seventy-three children were enrolled (telerehabilitation group: 48 children, waiting list group: 25 children). The results showed significant improvements in reading fluency, text dictation, and executive functions in the training group. Children attending a combined training including reading tasks and rapid automatized naming processes improved in word reading fluency and text dictation. The number of training sessions and the change in executive functions significantly correlated with changes in reading accuracy. Here we show a new contribution to telerehabilitation research in SLD: telerehabilitation significantly enhanced learning abilities and executive functions. Training based on the learning task and the underlying processes significantly increased not only reading speed, according to previous studies, but also writing accuracy. The findings’ implications in clinical research and practice are discussed.
Extracellular Nicotinamide Phosphoribosyltransferase as a Surrogate Marker of Prominent Malignant Potential in Colonic Polyps: A 2-Year Prospective Study
Authors: Chen Tsung-Hsing , Hsu Hung-Chih , You Jeng-Fu , Lai Cheng-Chou , Tsou Yung-Kuan , Hsu Chia-Lin , Fann Cathy S. J. , Chien Rong-Nan , Chang Ming-Ling
Published: March 2023

Background/aims: The implications of extracellular nicotinamide phosphoribosyltransferase (eNAMPT), a cancer metabokine, in colonic polyps remain uncertain. Methods: A 2-year prospective cohort study of patients who underwent colonoscopy was conducted. Biochemical parameters and serum eNAMPT levels were analyzed at baseline and every 24 weeks postpolypectomy. NAMPT-associated single-nucleotide polymorphisms (SNPs), including rs61330082, rs2302559, rs10953502, and rs23058539, were assayed. Results: Of 532 patients, 80 (15%) had prominent malignant potential (PMP) in colonic polyps, including villous adenomas (n = 18, 3.3%), adenomas with high-grade dysplasia (n = 33, 6.2%), and adenocarcinomas (n = 29, 5.5%). Baseline associations were as follows: colonic polyp pathology (p < 0.001), total cholesterol (p = 0.019), and neutrophil-to-lymphocyte ratio (p = 0.023) with eNAMPT levels; and age (p < 0.001), polyp size (p < 0.001), and eNAMPT levels (p < 0.001) with polyp pathology. Higher baseline eNAMPT levels were noted in patients harboring polyps with PMP than in patients without PMP (p < 0.001), and baseline eNAMPT levels significantly predicted PMP (cutoff: >4.238 ng/mL, p < 0.001). Proportions of eNAMPT-positive glandular and stromal cells were higher in polyps with PMP than in polyps without PMP (64.55 ± 11.94 vs. 14.82 ± 11.45%, p = 0.025). eNAMPT levels decreased within 48 weeks postpolypectomy (p = 0.01) and remained stable afterward regardless of PMP until 96 weeks postpolypectomy. However, those with PMP had a higher degree of eNAMPT decline within 24 weeks (p = 0.046). All investigated SNPs were in linkage disequilibrium with each other but were not associated with eNAMPT levels. Conclusion: With a link to inflammation and lipid metabolism, along with its decreasing trend after polypectomy, serum eNAMPT may serve as a surrogate marker of PMP in colonic polyps. In situ probing of the NAMPT-associated pathway holds promise in attenuating PMP, as much of the eNAMPT likely originates from colonic polyps.
Impact of Molecular Testing Using Next-Generation Sequencing in the Clinical Management of Patients with Non-Small Cell Lung Cancer in a Public Healthcare Hospital
Authors: Simarro Javier , Pérez-Simó Gema , Mancheño Nuria , Ansotegui Emilio , Muñoz-Núñez Carlos Francisco , Gómez-Codina José , Juan Óscar , Palanca Sarai
Published: March 2023

Next-generation sequencing (NGS) is a molecular approach able to provide a comprehensive molecular profile of non-small cell lung cancer (NSCLC). The broad spectrum of biomarker-guided therapies has positioned molecular diagnostic laboratories as a central component of patient clinical management. Here, we show the results of an UNE-EN ISO 15189:2022 NGS-accredited assay in a cohort of 350 patients. TP53 (51.0%), KRAS (26.6%) and EGFR (12.9%) were the most frequently mutated genes. Furthermore, we detected co-occurring and mutually exclusive alterations, as well as distinct molecular profiles according to sex and smoking habits. Actionable genetic alterations were significantly more frequent in female patients (80.5%, p < 0.001) and in never-smoker patients (87.7%, p < 0.001). When NGS was established as the main molecular testing strategy, 36.4% of patients received at least one line of targeted treatment. Among 200 patients with stage IV NSCLC, first-line treatment with targeted therapies was associated with a longer progression-free survival (PFS) (13.4 months (95% CI, 10.2–16.6) (p = 0.001)). Similarly, the overall survival (OS) of patients receiving at least one targeted drug was significantly longer (26.2 months (95% CI, 11.8–40.5) (p < 0.001)). Our results show that the implementation of NGS in the public healthcare system has provided a broader application of precision medicine.
Impact of Hormone Replacement Therapy on Risk of Ovarian Cancer in Postmenopausal Women with De Novo Endometriosis or a History of Endometriosis
Authors: Lee Hee Joong , Lee Banghyun , Choi Hangseok , Kim Taehee , Kim Yejeong , Kim Yong Beom
Published: March 2023

The effect of hormone replacement therapy (HRT) on the malignant transformation of postmenopausal endometriosis remains unclear. This study aimed to investigate the impact of HRT on ovarian cancer occurrence in postmenopausal women with de novo endometriosis or a history of endometriosis. A total of 10,304 women that received HRT (the HRT group) and 10,304 that did not (the control group) were selected by 1:1 matching those that met the study criteria. Incidences of ovarian cancer (0.3% in the HRT group and 0.5% in the control group) and cumulative incidence rates of ovarian cancer were similar in the two groups. The overall mean duration of HRT was 1.4 ± 2.2 years, but the duration of HRT in women with ovarian cancer was 2.2 ± 2.9 years. After adjusting for co-variables, receipt of HRT, duration of HRT, combined use of estrogen and progesterone, and tibolone were not found to be risk factors for ovarian cancer. However, the use of estrogen alone was found to be a significant risk factor for ovarian cancer (HR 2.898; 95% CI 1.251–6.715; p = 0.013). With the exception of HRT using estrogen alone, HRT did not increase the risk of ovarian cancer in postmenopausal women with a history of endometriosis or de novo endometriosis.
Proposal and Definition of an Intelligent Clinical Decision Support System Applied to the Screening and Early Diagnosis of Breast Cancer
Authors: Casal-Guisande Manuel , Álvarez-Pazó Antía , Cerqueiro-Pequeño Jorge , Bouza-Rodríguez José-Benito , Peláez-Lourido Gustavo , Comesaña-Campos Alberto
Published: March 2023

Breast cancer is the most frequently diagnosed tumor pathology on a global scale, being the leading cause of mortality in women. In light of this problem, screening programs have been implemented on the population at risk in the form of mammograms, starting in the 20th century. This has considerably reduced the associated deaths, as well as improved the prognosis of the patients who suffer from this disease. In spite of this, the evaluation of mammograms is not without certain variability and depends, to a large extent, on the experience and training of the medical team carrying out the assessment. With the aim of supporting the evaluation process of mammogram images and improving the diagnosis process, this work presents the design, development and proof of concept of a novel intelligent clinical decision support system, grounded on two predictive approaches that work concurrently. The first of them applies a series of expert systems based on fuzzy inferential engines, geared towards the treatment of the characteristics associated with the main findings present in mammograms. This allows the determination of a series of risk indicators, the Symbolic Risks, related to the risk of developing breast cancer according to the different findings. The second one implements a classification machine learning algorithm, which using data related to mammography findings as well as general patient information determines another metric, the Statistical Risk, also linked to the risk of developing breast cancer. These risk indicators are then combined, resulting in a new indicator, the Global Risk. This could then be corrected using a weighting factor according to the BI-RADS category, allocated to each patient by the medical team in charge. Thus, the Corrected Global Risk is obtained, which after interpretation can be used to establish the patient’s status as well as generate personalized recommendations. The proof of concept and software implementation of the system were carried out using a data set with 130 patients from a database from the School of Medicine and Public Health of the University of Wisconsin-Madison. The results obtained were encouraging, highlighting the potential use of the application, albeit pending intensive clinical validation in real environments. Moreover, its possible integration in hospital computer systems is expected to improve diagnostic processes as well as patient prognosis.
cRGD-Functionalized Silk Fibroin Nanoparticles: A Strategy for Cancer Treatment with a Potent Unselective Naphthalene Diimide Derivative
Authors: Pirota Valentina , Bisbano Giovanni , Serra Massimo , Torre Maria Luisa , Doria Filippo , Bari Elia , Paolillo Mayra
Published: March 2023

Developing drug delivery systems to target cytotoxic drugs directly into tumor cells is still a compelling need with regard to reducing side effects and improving the efficacy of cancer chemotherapy. In this work, silk fibroin nanoparticles (SFNs) have been designed to load a previously described cytotoxic compound (NDI-1) that disrupts the cell cycle by specifically interacting with non-canonical secondary structures of DNA. SFNs were then functionalized on their surface with cyclic pentapeptides incorporating the Arg-Gly-Asp sequence (cRGDs) to provide active targeting toward glioma cell lines that abundantly express ανβ3 and ανβ5 integrin receptors. Cytotoxicity and selective targeting were assessed by in vitro tests on human glioma cell lines U373 (highly-expressing integrin subunits) and D384 cell lines (low-expressing integrin subunits in comparison to U373). SFNs were of nanometric size (d50 less than 100 nm), round shaped with a smooth surface, and with a negative surface charge; overall, these characteristics made them very likely to be taken up by cells. The active NDI-1 was loaded into SFNs with high encapsulation efficiency and was not released before the internalization and degradation by cells. Functionalization with cRGDs provided selectivity in cell uptake and thus cytotoxicity, with a significantly higher cytotoxic effect of NDI-1 delivered by cRGD-SFNs on U373 cells than on D384 cells. This manuscript provides an in vitro proof-of-concept of cRGD-silk fibroin nanoparticles’ active site-specific targeting of tumors, paving the way for further in vivo efficacy tests.
Genomics of Breast Cancer Brain Metastases: A Meta-Analysis and Therapeutic Implications
Authors: Nguyen Thuy , Hamdan Diaddin , Angeli Eurydice , Feugeas Jean-Paul , Le Quang , Pamoukdjian Frédéric , Bousquet Guilhem
Published: March 2023

Breast cancer brain metastases are a challenging daily practice, and the biological link between gene mutations and metastatic spread to the brain remains to be determined. Here, we performed a meta-analysis on genomic data obtained from primary tumors, extracerebral metastases and brain metastases, to identify gene alterations associated with metastatic processes in the brain. Articles with relevant findings were selected using Medline via PubMed, from January 1999 up to February 2022. A critical review was conducted according to the Preferred Reporting Items for Systematic Review and Meta-analysis statement (PRISMA). Fifty-seven publications were selected for this meta-analysis, including 37,218 patients in all, 11,906 primary tumor samples, 5541 extracerebral metastasis samples, and 1485 brain metastasis samples. We report the overall and sub-group prevalence of gene mutations, including comparisons between primary tumors, extracerebral metastases and brain metastases. In particular, we identified six genes with a higher mutation prevalence in brain metastases than in extracerebral metastases, with a potential role in metastatic processes in the brain: ESR1, ERBB2, EGFR, PTEN, BRCA2 and NOTCH1. We discuss here the therapeutic implications. Our results underline the added value of obtaining biopsies from brain metastases to fully explore their biology, in order to develop personalized treatments.
Lattice Structure and Spatial Network Models Incorporating into Simulating Human-Mediated Dispersal of the Western Conifer Seed Bug Populations in South Korea
Authors: Zhang Xiaodong , Lee Dae-Seong , Park Young-Seuk , Heo Muyoung , Eom Il-Kyu , Bae Yang-Seop , Lee Tak-Gi , Chon Tae-Soo
Published: March 2023

The western conifer seed bug (WCSB), Leptoglossus occidentalis, has expanded rapidly in the southern peninsula of Korea since it was first reported in southeastern Korea in 2010. Two types of human-mediated passive movements were devised for modeling the rapid advancement of the pest population in this study: traffic effects and forest-product transportation. A lattice structure model (LSM) was developed to accommodate the traffic effects pertaining to the local area along with the natural population dynamics of the pest. Separately, a spatial network model (SNM) was constructed to present the passive movement of the WCSB because of forest-product transportation between all local areas in Korea. The gravity rule was applied to obtain the parameters for forest-product transportation between the local areas. LSM and SNM were linked to the two present types of passive movements in the model. The model simulated fast, linear advancement in a short period, compared with slow, circular advancement because of the conventional natural diffusion process of populations. Simulation results were comparable to field data observed in the southern peninsula of Korea, matching the rapid advancement of about 400 km to the north area (Seoul) from the south area (Changwon) within six years and expanding across the nation in 10 years. Possible saturation of populations was predicted in the 2020s if survival conditions for the WCSB were favorable and no control efforts were given in field conditions. Dispersal because of SNM notably surpassed the dispersal simulated by LSM when the WCSB population rapidly dispersed over a wide area. The Allee-effect and contribution ratio of SNM were the factors governing the rapid expansion of pest populations. The possibility of using the combined model was further discussed to address different types of human-mediated passive movements associated with population dynamics in forest pest dispersal.
Spatial Effect Analysis of Forestry Technology Innovation on Forestry Industry Economic Growth
Authors: Ma Zhuoya , Liu Tianle , Li Jing , Liu Zhentao , Chen Wenhui
Published: March 2023

The forestry industry is a low-carbon green industry with great potential for development, but its current development model is facing multiple dilemmas that urgently require a shift to high-quality forestry development. Neoclassical theory and endogenous growth theory consider technology innovation as the foundation of economic growth. In order to explore the impact of forestry technology innovation (FTI) on the economic growth of forestry industry, this paper uses the entropy method, spatial Durbin model, and threshold model to explore the spatial effect of forestry technology innovation on forestry industry economy for analysis and exploration of the non-linear relationship between the two, and the panel data from 31 provinces in China from 2002 to 2020 are used as the sample for empirical study. Results show that: (1) Forestry technology innovation has a significant role in promoting the economic growth of the forestry industry and has obvious spatial spillover effects, which also promotes the economic growth of forestry in neighboring regions. (2) There is a threshold effect of forestry technology innovation on the economic growth of the forestry industry. When the forestry technology innovation exceeds its optimal interval, its effect on the economic growth of forestry industry shows diminishing marginal benefits. (3) Forestry technology innovation has industrial heterogeneity on the economic growth of the forestry industry. Therefore, managers should take advantage of the growth effect of forestry technology innovation in the forestry industry at the level of sustainability, and further make full use of the spatial effect resulting from the flow of technology to establish a system of communication and learning to form a virtuous coordination of the forestry economic environment for the high-quality development of the forestry industry.