bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness of the Pattern-Based Approach in the Cytodiagnosis of Salivary Gland Lesions
Authors: Amita K. , Vijay Shankar S. , Sanjay M. , Sarvesh B.M.
Published: April 2016

Objective: The aim of this study is to investigate, primarily, the effectiveness of the application of pattern-based analysis in the diagnosis of salivary gland (SG) lesions. Secondarily, an attempt was made to study the cytomorphology of the various lesions in detail and discuss the pitfalls and solutions involved in the challenging conditions at cytology. Materials and Methods: This was a prospective, cross-sectional study. All SG lesions over 2 years were subjected to fine-needle aspiration cytology with patients' prior informed consent. The lesions were classified based on the predominant pattern, and a provisional diagnosis was made. The secondary pattern and other features, such as background, were then taken note of, and a combined cytological diagnosis was rendered. The entire spectrum of lesions was divided into 6 morphological categories. Results: We had a total of 72 SG lesions. The most commonly affected gland was the parotid gland in 79.16% (57/72) of the cases. Surgery was performed in 26 cases (36.11%). A concordant diagnosis was obtained in 22 cases. The sensitivity, specificity and diagnostic accuracy by the pattern-based approach was 75, 100 and 88.46%, respectively. There were no false-positive cases, but 2 false-negative cases were recorded. Conclusion: The precise cytological preoperative diagnosis of SG lesions is important for the management of patients. The pattern-based approach can be used routinely in the cytological diagnosis of SG lesions.
Influence of Gender and Repeated Urine Sampling on the Association of Albuminuria with Coronary Events
Authors: Hatlen Gudrun , Romundstad Solfrid , Salvesen Øyvind , Dalen Havard , Hallan Stein I.
Published: April 2016

Background: The association between albuminuria and coronary heart disease (CHD) is well-known, but uncertainties related to day-to-day variability and effect modification of gender complicate the risk assessment process. This study evaluates the associations of CHD with albuminuria level in men and women based on the number of urine samples. Methods: Nine thousand one hundred and fifty-eight adults provided 3 urine samples and were followed for 14 years in the population-based HUNT-2 cohort study. The association of myocardial infarction or coronary death with different albumin-creatinine ratio (ACR) cut-offs, based on gender and number of positive ACRs, were estimated by hazard ratios (HRs) and adjusted for by Framingham variables. Results: Associations between ACR and CHD were similar in men and women. For example, HRs for moderately increased (3.0≤ ACR ≤30.0 mg/mmol) vs. normal albuminuria (ACR <1.0 mg/mmol) were 1.40 (95% CI 1.27-2.03) and 1.61 (95% CI 1.15-1.71) respectively, (psex-equality = 0.3). However, median intra-individual day-to-day ACR coefficient of variation was 22.4% in women vs. 17.5% in men (p < 0.001). Two or 3 positive ACRs were required to establish a significant association with CHD at levels below 4.0 mg/mmol in women, while one positive ACR implied a significant association at all levels in men. Based on receiver-operating-characteristics curves, the Youden index suggested possible equal cut-offs for women (1.12 mg/mmol) and men (0.88 mg/mmol), p = 0.06. Conclusions: There were no significant gender differences in the association between albuminuria and coronary events. However, women had increased intra-individual albuminuria variability compared to men, necessitating several positive urine samples if mildly increased albuminuria is used in coronary risk evaluation.
mFOLFOX6 Chemotherapy after Resection of Anal Canal Mucinous Adenocarcinoma
Authors: Matsunaga Mototsugu , Miwa Keisuke , Oka Yosuke , Nagasu Sachiko , Sakaue Takahiko , Fukahori Masaru , Ushijima Tomoyuki , Akagi Yoshito
Published: April 2016

Because of their rarity, there are no clear guidelines for the treatment of anal carcinomas; such tumors are normally subjected to the same modalities as recommended for rectal cancer. We report a patient with anal canal mucinous adenocarcinoma, with metastases in the pararectal and right inguinal lymph nodes, who was treated with abdominoperineal resection followed by mFOLFOX6 chemotherapy for 6 months (12 cycles). The patient has remained recurrence-free thus far, approximately 2 years since the surgery. As the optimal treatments for anal carcinomas have not been fully elucidated, we present this case to highlight a possible course of action for such patients that appears to be effective and promising.
Ultrasound-Guided Shockwave Lithotripsy Reduces Radiation Exposure and Has Better Outcomes for Pediatric Cystine Stones
Authors: Goren Mehmet Resit , Goren Vinil , Ozer Cevahir
Published: April 2016

Background/Aims/Objectives: To evaluate the outcomes and ionizing radiation (IR) exposure of children with cystine stones (CS) using different shockwave lithotripsy (SWL) guidance modalities. Methods: Data from pediatric patients with renal stones treated between January 2009 and August 2015 were retrospectively reviewed. Outcome results and IR exposure in patients undergoing fluoroscopy (FL)-guided SWL and ultrasonography (US)-guided SWL were compared. First-time stone formers and those treated with SWL and with complete follow-up data, including post-treatment stone analysis confirming CS were included. Results: Forty-four patients (16 girls and 28 boys) met the inclusion criteria. Results of SWL performed in 51 kidneys were analyzed. After the SWL, 41 (80.4%) of 51 kidneys were stone free, and 10 (19.6%) had clinically insignificant residual fragments (≤3 mm) or unfragmented stones. The success rates differed between patients in Group-FL (60%) and Group-US (93.5%) (p = 0.008). Single-session success rates were higher, and prospects of retreatment were lower in Group-US (p = 0.000 and p = 0.002, respectively). In addition, overall complications were significantly lower in Group-US (p = 0.042). Overall IR exposure was higher in Group-FL (p = 0.013). Conclusions: US-guided SWL is more effective for pediatric CS and should be considered a preferred treatment to reduce IR doses in children.
Com a palavra os Mestres Griôs
Authors: Choe Winny
Published: April 2016

O seguinte artigo propõe-se a uma reflexão sobre o processo de interação entre os mestres de Tradição Oral (e seus conhecimentos) e a escola – lugar por excelência da educação formal. Esta reflexão tem por base os depoimentos de Mestres de tradição oral integrantes do Programa Ação Griô Nacional. Os depoimentos são analisados buscando perceber o processo de interação entre conhecimento tradicional de tradição oral no espaço da educação formal fundamentados pelos conceitos de cultura hegemônica, cultura subalterna e cultura popular.
O projeto Teatro a Bordo e a descentralização da cultura
Authors: Pires Patricia Limeres
Published: April 2016

Este artigo visa a reflexão, a partir das fontes bibliográficas, a respeito da democratização e descentralização cultural necessárias para a formação de um público crítico consumidor de cultura. Para isso, propõe-se a análise do ciclo da cadeia produtiva da cultura, sob o recorte de produção, distribuição e consumo, a fim de identificar os possíveis impactos que comprometam a efetivação desse ciclo. Tal análise é desenvolvida a partir do estudo e observação participativa do projeto “Teatro a Bordo”, como alternativa criativa e viável para suprir a carência de infraestrutura para a atividade artística na maioria dos municípios brasileiros.
Fomentando as Indústrias Criativas: uma Análise das Políticas Federais para o Audiovisual no Brasil
Authors: Ferreira Fábio , Jambeiro Othon
Published: April 2016

Esse paper apresenta os resultados de uma pesquisa financiada pelo CNPq para estudar o fomento à produção audiovisual no Brasil. A pesquisa baseou-se no conceito de indústrias criativas e possuía três objetivos: caracterizar as ações correntes do governo federal de fomento à produção audiovisual; compreender as relações entre as ações de fomento e o conceito de indústrias criativas; identificar as redes que se formam entre os atores envolvidos na elaboração de políticas de fomento para o setor. O método incluiu: análise de websites, questionários e entrevistas. Os resultados demonstraram que as políticas de fomento são fortemente marcadas por suporte financeiro, mas, também, por esforços para gerar sustentabilidade econômica das firmas no setor audiovisual. Os fomentadores indicam como necessidades no setor: mais informações sobre o mercado audiovisual; melhor capacitação em negócios entre os produtores; e maiores recursos orçamentários e humanos para implementar as políticas. Os agentes fomentadores usam o conceito de indústrias criativas, mas ele não é um elemento central nas suas políticas. Eles estabelecem relações entre si para as ações de fomento, mas nem todos se relacionam com todos.
Imprensa universitária no Brasil: a trajetória da Agência Universitária de Notícias (AUN) durante a ditadura militar e no novo período democrático
Authors: Silva André Chaves de Melo , Martins Leandra Rajczuk , Proença José Luiz
Published: April 2016

Este artigo  centra seu foco na trajetória histórica da Agência Universitária de Notícias (AUN). Pioneira no Brasil, esta mídia, vinculada à Universidade de São Paulo (USP), passou pelo período em que enfrentou interrupções em sua periodicidade – incluindo entre as causas pressões exercidas sobre sua atuação por agentes do Regime Militar Brasileiro (1964-1985) – e, depois, entrou, paulatinamente, em uma fase de estabilidade, vivida graças à redemocratização do País, passando do impresso para o digital e, recentemente, inaugurando seu novo site informativo (www.usp.br/aun)Palavras-chave: jornalismo; Agência Universitária de Notícias (AUN); democracia
Um Fenômeno Fashion: os rolês na mídia
Authors: Villaça Nizia Maria Souza
Published: April 2016

Focamos aqui um novo desenho que se forma ao ritmo do apelo contemporâneo da visibilidade e da fama: o caso dos rolês. A glorificação da vitória social e a apologia do consumo na sociedade contemporânea rendem culto à performance e ao desempenho, buscando formas de seduzir os consumidores e sugerir comportamentos. O estilo performático é ativado constantemente pela publicidade. A técnica utilizada trabalha com a adulação das minorias no seu desejo de reconhecimento. A moda possui hoje uma lógica que articula as relações sociais conectando o mundo das celebridades e o dos anônimos que buscam identificação, reconhecimento e inclusão. Neste cenário vamos analisar o comportamento dos “rolezinhos”. A mídia se esforça por definir seu DNA da mesma forma que correu atrás de definições/explicações. Identidade e diferença constituem um pólo de grande importância nas práticas discursivas, cujas estratégias exigem sempre mais acuidade dos críticos/semiólogos, em meio à dissolução geral das fronteiras. Apartheid ou arrastão?
Publicidade on-line: comunicação interativa
Authors: Gonzales Lucilene Dos Santos , Seridório Daniele Ferreira
Published: April 2016

A publicidade na era digital reconfigurou-se; seus tradicionais paradigmas estão obsoletos, principalmente no que diz respeito à interação com seu público-alvo. Antes considerada uma comunicação em um só sentido, em que o fabricante e o anunciante se dirigem a um público que não podiam responder à comunicação emitida, agora o consumidor tem voz opina sobre a marca e é também co-produtor de marcas e produtos. As plataformas e estratégias dessa publicidade online interativa  são objeto de reflexão deste artigo.
Sustentabilidade: a legitimação de uma nova cultura
Authors: Juski Juliane Do Rocio , Ribeiro Regiane Regina
Published: April 2016

Apenas nas últimas décadas que a humanidade se deu conta das limitações do mundo natural e as alterações climáticas que o modelo de consumismo perverso que privilegia poucos e compromete a sobrevivência de muitos pode fazer. Reconfigurou-se então o pensamento ecológico, foi necessário fazer uma crítica cultural desse modelo de civilização. O novo pensamento só pode ser alterado através de uma mudança cultural no estilo de vida da humanidade, no desenvolvimento de um novo modelo mais harmônico, justo e equilibrado. E é neste contexto que pretendemos explorar no artigo, evidenciando as nuances entre a sustentabilidade e a cultura, e como a sustentabilidade vem se legitimando como uma nova cultura civilizatória.
From normative imaginary reality of the Network of Emergency Care
Authors: Almeida Adriana C. , Gusmão Filho Fernando A. R. , Caldas Junior Arnaldo F. , Vidal Suely A. , Campello Reginaldo I. C.
Published: April 2016

Study design: a case study. Objective: To analyze the Emergency Care Network from the perspective of the Mobile Emergency Care Service of the Metropolitan Recife (SAMU). Material and Method: a case study with multiple units of analysis. The object of the study was the SAMU and the units of analysis were the components: promotion, prevention and health surveillance; organization and governance of the network. We opted for the triangulation of methods and sources, using semistructured interviews with 57 professionals working in this service; direct observation and official documents (database, ordinances and reports). For the analysis of qualitative data we used the technique of condensing meanings and quantitative, the average frequency of events. Results: The profile of the professionals interviewed shows that 53% were male, 65%, had graduated less than 12 years, a little more than half worked in the SAMU for less than 2 years and 77% had temporary employment through contracts with the municipalities. According to the interviewees there are strategies of promotion and prevention, but one cannot see changes in the epidemiological and demographic profile as a result of the implementation of these strategies. There is an inadequate distribution of health equipment; low health coverage of the population (50% of PSF coverage / ESF and deficit of 3,089 hospital beds) and lack of coordination between the state regional steering committee of the care system emergencies.Conclusion: The lack of information on care management in the emergency area, promotion and prevention strategies generates discontinuity in the process of surveillance, added by communication failures across the SAMU service network. Therefore, there is a deficit and inadequacy of health coverage. The lack of integration between services, the difficulty of access and the patient continuity on the treatment demonstrates the inadequate governance of the service network to the emergency room
Transformation of benign phyllodes to malignant phyllodes tumor
Authors: Lucarelli Adrienne Pratti , Martins Maria Marta , Galvão Maria Antonieta Longo , Aldrighi José Mendes
Published: April 2016

Importance of the problem: Malignant phyllodes tumors are rare fibroepithelial neoplasm in which clinical findings remain insufficient to determine a proper preoperative diagnoses and therefore has an unpredictable clinical outcome for optimal treatment. Few cases have been published involving malignant transformation of benign phyllodes to a malignant phyllodes tumor. These tumors should be suspected in patients with rapid-growing breast nodules to avoid incorrect treatment. Aims: Document a case of a transformation of benign to malignant phyllodes. Methods: A 23-year-old female patient presented a two-month history of palpable mass on the left breast, with accelerated growth in last month. There was no personal or family history of breast Cancer. This patient was submitted to the removal of a nodule in the left breast a year and a half prior. The physical exam presented a protruding and hardened palpable mass with a diameter of 5x6 cm and a histologically diagnosis of benign phyllodes tumor and an areolar incision was made. Results: At that time, the physical exam presented the palpable mass occupying the upper quadrants of the left breast with the dimensions of 4.5x2.0 cm. Signs of skin involvement or axillary lymphadenomegaly were not found. During the diagnostic investigation, the patient was submitted to mammogram and ultrasound. Because of the extension of the lesions, the patient underwent a skinspearing mastectomy with protests without axillary dissection. Surgical margins were free of any signs of the tumor. Macroscopy evidenced a lesion measuring 4,5x3,0 cm, and the anatomopathologic analysis of the surgical specimen confirmed the diagnosis of malignant phyllodes tumor. Comments: In our study, malignant transformation was determined one year after operation. The outcome of cases with history of fibroadenoma or benign phyllodes are significantly better than that of cases without history of benign tumor however, patients with malignant phyllodes tumors who exhibit rapid growth within six months require aggressive treatment
Voz e memória cultural em Litoral: Reseña de una vida inútil (1926- 1959), de Luis Palés Matos
Authors: Josiowicz Alejandra
Published: April 2016

O artigo propõe uma análise da questão da sonoridade em uma seleção dos escritos do poeta porto-riquenho Luis Palés Matos (1898-1959) através da relação com a me­mória coletiva das Antilhas. Examino a impor­tância da musicalidade em dois níveis diferen­tes: no nível da forma estética – na sonoridade, no ritmo – e no nível das representações sociais e políticas – na cultura popular, de herança africana e mestiça, até então considerada mar­ginal. Esses dois níveis do fenômeno musical apontam para a vontade do escritor de trans­formar a relação entre o discurso estético e a coletividade por meio da criação, no marco do Porto Rico moderno, de uma nova compreen­são da cultura, da língua e dos rituais religiosos das Antilhas.
Apostolic Networks in the Third Wave of the Spirit
Authors: Bialecki Jon
Published: April 2016

This essay discusses the relationship between the Vineyard and the various other apostolic networks. By comparing the Vineyard with C. Peter Wagner and the New Apostolic Revival, I contend that the chief difference between these two movements lies in a Vineyard interest in pedagogy over a New Apostolic Revival interest in governance, and in the Vineyard’s use of the figure of John Wimber as an exemplar for practice rather than as a figure of authority.
In Search of a “Pentecostal” Epistemology
Authors: Frestadius Simo
Published: April 2016

Pentecostal theologians are increasingly aware that there cannot be an authentic pentecostal theology without a distinct pentecostal epistemology, or at least an epistemology that is compatible with pentecostal spirituality, beliefs, and practices. To date, Amos Yong and James Smith have arguably provided the most philosophically mature pentecostal theories of knowledge. They have not only constructed insightful theological epistemologies based on pentecostal presuppositions, but seem also to have provided pentecostal versions of “correlationist” and “postliberal” approaches to theological epistemology. The purpose of this article is to assess the pentecostal epistemologies of Yong and Smith, offer evaluative comments on their approaches, and suggest that pentecostal theologians/philosophers would significantly benefit from familiarizing themselves with and building on the epistemologies of Yong and Smith as the search for pentecostal epistemologies continues.
Revision of the genus Pselaphomorphus Motschulsky, 1855 (Staphylinidae, Pselaphinae: Jubini)
Authors: VÁSQUEZ-VÉLEZ LAURA M.
Published: April 2016

The genus Pselaphomorphus Motschulsky, 1855 is revised to include 33 species. The type species, Pselaphomorphus sculpturatus Motschulsky, 1855, and the previously described species P. longiceps Raffray, 1890 and P. microphthalmus Raffray, 1890 are redescribed, and the original description of P. brevipennis Raffray, 1917 and P. bruchi Raffray, 1918 are translated from Latin and French to English. The following species are described as new: P. acutispinosus n. sp. from Peru, P. agametopus n. sp. from Colombia, P. azuayensis n. sp. from Ecuador, P. bolivarensis n. sp. from Venezuela, P. breviantennae n. sp. from Bolivia, P. carenobothrus n. sp. from Peru, P. carltoni n. sp. from Ecuador, P. cayennensis n. sp. from French Guiana, P. chandleri n. sp. from Panama, P. fluminosus n. sp. from Venezuela, P. iguazuensis n. sp. from Argentina, P. incorum n. sp. from Peru, P. longissimus n. sp. from Panama, P. macrommatus n. sp. from Ecuador, P. maldonadensis n. sp. from Peru, P. mayaorum n. sp. from Honduras, P. melanus n. sp. from Costa Rica, P. montsineryensis n. sp. from French Guiana, P. motschulskyi n. sp. from Costa Rica, P. newtoni n. sp. from Brazil, P. parki n. sp. from Costa Rica, P. raffrayi n. sp. from Peru, P. santaecrucis n. sp. from Bolivia, P. simplicipenis n. sp. from French Guiana, P. thayerae n. sp. from Brazil, P. tucumanensis n. sp. from Argentina, P. veracruzanus n. sp. and P. wagneri n. sp., both from Mexico. A key to the species, color photographs and genitalia illustrations are provided.
A new species of Dyspessa Hübner, (Lepidoptera, Cossidae) from Western China, with catalogue of Chinese species of the genus
Authors: YAKOVLEV ROMAN V. , SALDAITIS AIDAS , PEKARSKY OLEG
Published: April 2016

The genus Dyspessa is the largest genus of carpenter moths including 60 valid species, widely distributed in Western Palearctic, especially in Sahara desert, Minor Asia, Iran and Central Asia (Yakovlev 2011; 2015). Most of the species have a small distribution range, limited by mountain ranges or deserts (Yakovlev & Dubatolov 2013). The only known trophic preferences of Dyspessa are their specialization to different species of the plant genus Allium (Alliaceae) (Yakovlev 2015). There are only three species known from China, Xinjiang Uyghur Autonomous Region: Dyspessa saissanica Yakovlev, 2014 (erroneously listed for Hami (Xinjiang) as Dyspessa salicicola (Eversmann, 1848) (Yakovlev 2005), Dyspessa tristis A. Bang-Haas, 1912 (known by a single male from Chinese part of Mongolian Altai mountains collected by Grigory Grumm-Grzhimaylo (probably in June 2003, Kurtu river of Kran river basin) and Dyspessa rueckbeili Yakovlev, 2007, described from Central Asia, Altyn Tagh [Altun Shan] (Altun Shan is a mountain range in northwestern China that separates the eastern Tarim Basin from the Tibetan Plateau (Yakovlev 2007). The western third is in Xinjiang while the eastern part forms the border between Qinghai to the south and Xinjiang and Gansu to the north). During a study of the new Dyspessa specimens from Western China, West South part of Xinjiang the new species, described below, was found.
Redescription of Draposa subhadrae (Patel & Reddy, 1993) (Araneae: Lycosidae, Pardosinae)
Authors: MARUSIK YURI M. , OMELKO MIKHAIL M.
Published: April 2016

Draposa Kronestedt, 2010 is a small genus of Pardosinae spiders. Currently it encompasses 10 species (World Spider Catalog 2016) distributed from Pakistan to Southeast China. Most species of the genus, except for D. porpaensis (Gajbe, 2004), are known from both sexes and were described or redescribed by Kronestedt (2010). Two other species, D. amkhasensis (Tikader & Malhotra, 1976) and D. burasantiensis (Tikader & Malhotra, 1976), both recently transferred to Draposa (Dhali et al. 2012 ), are doubtful because their copulatory organs are not properly illustrated and differ from the type species and other species of the genus. The male of Draposa subhadrae (Patel & Reddy, 1993) remains known by very poor original drawings because Kronestedt (2010) was not able to study types. While studying material from Sri Lanka collected by us, we found one sample with two females belonging to D. subhadrae and two males of Draposa having the same colour pattern and size. We concluded that these specimens are conspecific. The goal of this paper is to provide an illustrated redescription of this species.
A Comparison of Antarctic Ice Sheet Surface Mass Balance from Atmospheric Climate Models and In Situ Observations
Authors: Wang Yetang , Ding Minghu , van Wessem J. M. , Schlosser E. , Altnau S. , van den Broeke Michiel R. , Lenaerts Jan T. M. , Thomas Elizabeth R. , Isaksson Elisabeth , Wang Jianhui , Sun Weijun
Published: April 2016

In this study, 3265 multiyear averaged in situ observations and 29 observational records at annual time scale are used to examine the performance of recent reanalysis and regional atmospheric climate model products [ERA-Interim, JRA-55, MERRA, the Polar version of MM5 (PMM5), RACMO2.1, and RACMO2.3] for their spatial and interannual variability of Antarctic surface mass balance (SMB), respectively. Simulated precipitation seasonality is also evaluated using three in situ observations and model intercomparison. All products qualitatively capture the macroscale spatial variability of observed SMB, but it is not possible to rank their relative performance because of the sparse observations at coastal regions with an elevation range from 200 to 1000 m. In terms of the absolute amount of observed snow accumulation in interior Antarctica, RACMO2.3 fits best, while the other models either underestimate (JRA-55, MERRA, ERA-Interim, and RACMO2.1) or overestimate (PMM5) the accumulation. Despite underestimated precipitation by the three reanalyses and RACMO2.1, this feature is clearly improved in JRA-55. However, because of changes in the observing system, especially the dramatically increased satellite observations for data assimilation, JRA-55 presents a marked jump in snow accumulation around 1979 and a large increase after the late 1990s. Although precipitation seasonality over the whole ice sheet is common for all products, ERA-Interim provides an unrealistic estimate of precipitation seasonality on the East Antarctic plateau, with high precipitation strongly peaking in summer. ERA-Interim shows a significant correlation with interannual variability of observed snow accumulation measurements at 28 of 29 locations, whereas fewer than 20 site observations significantly correlate with simulations by the other models. This suggests that ERA-Interim exhibits the highest performance of interannual variability in the observed precipitation.
The use of engineered protein materials in electrochemical devices
Authors: Renner Julie N , Minteer Shelley D
Published: April 2016

Bioelectrochemical technologies have an important and growing role in healthcare, with applications in sensing and diagnostics, as well as the potential to be used as implantable power sources and be integrated with automated drug delivery systems. Challenges associated with enzyme-based electrodes include low current density and short functional lifetimes. Protein engineering is emerging as a powerful tool to overcome these issues. By taking advantage of the ability to precisely define protein sequences, electrodes can be organized into high performing structures, and enable the next generation of medical devices.
Lymphoma development and survival in refractory coeliac disease type II: Histological response as prognostic factor
Authors: Nijeboer P , van Wanrooij RLJ , van Gils T , Wierdsma NJ , Tack GJ , Witte BI , Bontkes HJ , Visser O , Mulder CJJ , Bouma G
Published: April 2016

Background

Refractory coeliac disease type II (RCDII) frequently transforms into an enteropathy‐associated T‐cell lymphoma (EATL) and therefore requires intensive treatment. Current evaluated treatment strategies for RCDII include cladribine (2‐CdA) and autologous stem cell transplantation (auSCT).

Objective

The purpose of this study was to evaluate long‐term survival and define clear prognostic criteria for EATL development comparing two treatment strategies.

Methods

A total of 45 patients were retrospectively analysed. All patients received 2‐CdA, after which they were either closely monitored (monotherapy, n  = 30) or a step‐up approach was used including auSCT (step‐up therapy, n  = 15).

Results

Ten patients (22%) ultimately developed EATL; nine of these had received monotherapy. Absence of histological remission after monotherapy was associated with EATL development (p  = 0.010). Overall, 20 patients (44%) died with a median survival of 84 months. Overall survival (OS) within the monotherapy group was significantly worse in those without histological remission compared to those with complete histological remission(p  = 0.030). The monotherapy group who achieved complete histological remission showed comparable EATL occurrence and OS as compared to the step‐up therapy group (p  = 0.80 and p  = 0.14 respectively).

Conclusion

Histological response is an accurate parameter to evaluate the effect of 2‐CdA therapy and this parameter should be leading in the decisions whether or not to perform a step‐up treatment approach in RCDII.
Newswork, News Values, and Audience Considerations
Authors: Sherwood Merryn , Osborne Angela , Nicholson Matthew , Sherry Emma
Published: April 2016

Substantial research indicates that women’s sports and female athletes gain only a small fraction of sports media coverage worldwide. Research that has examined why this is the case suggested this can be attributed to three particular factors that govern sports newswork: the male-dominated sports newsroom, ingrained assumptions about readership, and the systematic, repetitive nature of sports news. This study sought to explore women’s sports coverage using a different perspective, exploring cases where women’s sports gained coverage. It identified Australian newspapers that published more articles on women’s sports, relative to their competitors, and conducted interviews with both journalists and editors at these newspapers. It found that small, subtle changes to the three newswork elements that had previously relegated the coverage of women’s sports now facilitated it. This research provides evidence that, at least in some newspapers in Australia, sports newswork has developed to include the coverage of women’s sports.
Coquandite, Sb6+xO8+x(SO4)(OH)x·(H2O)1–x (x = 0.3), from the Cetine mine, Tuscany, Italy: crystal structure and revision of the chemical formula
Authors: Bindi L. , Biagioni C. , Ceccantini L. , Batoni M. , Menchetti S.
Published: April 2016

The crystal structure of the mineral coquandite, a rare Sb oxy-sulfate hydrate, was solved using intensity data collected from a crystal from the Cetine mine, Tuscany, Italy. This study revealed that the structure is triclinic, space group P, with a = 11.4292(5), b = 29.772(1), c = 11.2989(5) Å, α = 91.152(3), β = 119.266(4), γ = 92.624(3)° and V = 3346.4(2) Å3. The refinement of an anisotropic model led to an R index of 0.0347 for 21,061 independent reflections. Thirty-two Sb sites, five S sites and 67 oxygen sites occur in the crystal structure of coquandite. Sb atoms display the characteristic SbO3E and SbO4E coordinations whereas S fills (SO4) tetrahedral groups. These atoms are arranged in five symmetry-independent layers perpendicular to b*. Four of them and their centrosymmetrical counterparts form complex modules stacked along b* and bonded through two Sb atoms and H bonds. The complex H bonding system in the structure is discussed. On the basis of information gained from this characterization, the crystal-chemical formula was revised according to the structural results, yielding Sb6+xO8+x(SO4)(OH)x·(H2O)1–x (Z = 10) with x = 0.3 instead of Sb6O8(SO4)·H2O (Z = 12) as reported previously. A recalculation of the chemical data listed in the scientific literature for coquandite according to the structural results obtained here leads to a satisfactory agreement.
The crystal structure of arangasite, Al2F(PO4)(SO4)·9H2O determined using low-temperature synchrotron data
Authors: Yakubovich O. V. , Steele I. M. , Chernyshev V. V. , Zayakina N. V. , Gamyanin G. N. , Karimova O. V.
Published: April 2016

The crystal structure of the fibrous mineral arangasite, Al2F(PO4)(SO4)·9H2O from the Alyaskitovoje deposit, Eastern Yakutiya, Russia, was solved using low-temperature single-crystal data from synchrotron radiation and refined against F2 to R = 9.8%. Arangasite crystallizes in the monoclinic space group P2/a, with unit-cell parameters a = 7.073(1), b = 9.634(2), c = 10.827(2) Å, β = 100.40(1)°, V = 725.7(7) Å3 and Z = 2. The positions of all the independent H atoms were obtained by difference- Fourier techniques and refined in an isotropic approximation. The arangasite crystal structure is built from one-dimensional chains of Al octahedra and PO4 tetrahedra sharing vertices, quasi-isolated SO4 tetrahedra and H2O molecules. All O atoms are involved in the system of H bonding, acting as donors and/or acceptors. Hydrogen bonding serves as the only mechanism providing linkage between the main structural fragments, thus maintaining the framework. Chains of corner-sharing Al octahedra and P tetrahedra in the arangasite structure are topologically identical to the chains built from (Fe, Al) octahedra and P tetrahedra in the crystal structure of destinezite, Fe2(OH)(PO4)(SO4)·6H2O. It has been shown that in spite of very similar chemical formulae, arangasite and sanjuanite, Al2(OH)(PO4)(SO4)·9H2O, are not isotypic.
Major element and oxygen isotope geochemistry of vapour-phase garnet from the Topopah Spring Tuff at Yucca Mountain, Nevada, USA
Authors: Moscati R. J. , Johnson C. A.
Published: April 2016

Twenty vapour-phase garnets were studied in two samples of the Topopah Spring Tuff of the Paintbrush Group from Yucca Mountain, in southern Nevada. The Miocene-age Topopah Spring Tuff is a 350 m thick, devitrified, moderately to densely welded ash-flow tuff that is zoned compositionally from high-silica rhyolite to latite. During cooling of the tuff, escaping vapour produced lithophysae (former gas cavities) lined with an assemblage of tridymite (commonly inverted to cristobalite or quartz), sanidine and locally, hematite and/or garnet. Vapour-phase topaz and economic deposits associated commonly with topaz-bearing rhyolites (characteristically enriched in F) were not found in the Topopah Spring Tuff at Yucca Mountain. Based on their occurrence only in lithophysae, the garnets are not primary igneous phenocrysts, but rather crystals that grew from a F-poor magmaderived vapour trapped during and after emplacement of the tuff. The garnets are euhedral, vitreous, reddish brown, trapezohedral, as large as 2 mm in diameter and fractured. The garnets also contain inclusions of tridymite. Electron microprobe analyses of the garnets reveal that they are almandinespessartine (48.0 and 47.9 mol.%, respectively), have an average composition of (Fe1.46Mn1.45Mg0.03Ca0.10)(Al1.93Ti0.02)Si3.01O12and are comparatively homogeneous in Fe and Mn concentrations from core to rim. Composited garnets from each sample site have δ18O values of 7.2 and 7.4%. The associated quartz (after tridymite) has δ18O values of 17.4 and 17.6%, values indicative of reaction with later, low-temperature water. Unaltered tridymite from higher in the stratigraphic section has a δ18O of 11.1% which, when coupled with the garnet δ18O values in a quartz-garnet fractionation equation, indicates isotopic equilibration (vapour-phase crystallization) at temperatures of ∼600°C. This high-temperature mineralization, formed during cooling of the tuffs, is distinct from the later and commonly recognized low-temperature stage (generally 50−70°C) of calcite, quartz and opal secondary mineralization, formed from downward-percolating meteoric water, that locally coats fracture footwalls and lithophysal floors.
Incidence and prevalence of idiopathic pulmonary fibrosis in US adults 18–64 years old
Authors: Raghu Ganesh , Chen Shih-Yin , Hou Qiang , Yeh Wei-Shi , Collard Harold R.
Published: April 2016

We sought to present the epidemiology of idiopathic pulmonary fibrosis (IPF) in adults 18–64 years old in the USA.

From adults aged 18–64 years in a large administrative claims data in 2004–2010, patients with IPF were identified using diagnosis codes. We estimated annual incidence and cumulative prevalence of IPF over time, and examined potential risk factors for the IPF diagnosis.

The annual cumulative prevalence increased steadily in the first few years (from 13.4 cases per 100 000 persons in 2005 to 18.2 cases in 2010 per 100 000 persons), which is likely due to a methodological reason, while the annual incidence of IPF decreased over time (from 7.9 cases per 100 000 person-years in 2005 to 5.8 cases in 2010 per 100 000 person-years). The overall decrease was mainly driven by a decreasing trend in the younger patients (aged 18–44 years), while the incidence in older patients remained stable. Consistent trends were observed in subgroups defined by previously published more restrictive algorithms for diagnosis. Older age and male sex were associated with a higher incidence of disease (p<0.05).

In US adults younger than 65 years, we observed a decreasing incidence of IPF over time which may partially explain the plateau of cumulative prevalence in the last few years of our data.
Characteristics of effective self-management interventions in patients with COPD: individual patient data meta-analysis
Authors: Jonkman Nini H. , Westland Heleen , Trappenburg Jaap C.A. , Groenwold Rolf H.H. , Bischoff Erik W.M.A. , Bourbeau Jean , Bucknall Christine E. , Coultas David , Effing Tanja W. , Epton Michael , Gallefoss Frode , Garcia-Aymerich Judith , Lloyd Suzanne M. , Monninkhof Evelyn M. , Nguyen Huong Q. , van der Palen Job , Rice Kathryn L. , Sedeno Maria , Taylor Stephanie J.C. , Troosters Thierry , Zwar Nicholas A. , Hoes Arno W. , Schuurmans Marieke J.
Published: April 2016

It is unknown whether heterogeneity in effects of self-management interventions in patients with chronic obstructive pulmonary disease (COPD) can be explained by differences in programme characteristics. This study aimed to identify which characteristics of COPD self-management interventions are most effective.

Systematic search in electronic databases identified randomised trials on self-management interventions conducted between 1985 and 2013. Individual patient data were requested for meta-analysis by generalised mixed effects models.

14 randomised trials were included (67% of eligible), representing 3282 patients (75% of eligible). Univariable analyses showed favourable effects on some outcomes for more planned contacts and longer duration of interventions, interventions with peer contact, without log keeping, without problem solving, and without support allocation. After adjusting for other programme characteristics in multivariable analyses, only the effects of duration on all-cause hospitalisation remained. Each month increase in intervention duration reduced risk of all-cause hospitalisation (time to event hazard ratios 0.98, 95% CI 0.97–0.99; risk ratio (RR) after 6 months follow-up 0.96, 95% CI 0.92–0.99; RR after 12 months follow-up 0.98, 95% CI 0.96–1.00).

Our results showed that longer duration of self-management interventions conferred a reduction in all-cause hospitalisations in COPD patients. Other characteristics are not consistently associated with differential effects of self-management interventions across clinically relevant outcomes.
WAR AND PEACE
Authors: Morson Gary Saul
Published: April 2016

Despite their professed multiculturalism, educated Americans find it hard to imagine that others do not share their liberal values. Does not everyone love their children and want peace? The author of the article, a Tolstoy scholar and student of Russian culture, discusses topics—war, revolution, and what one scholar has called “secular kenosis”—that mark radical differences between Russians and Americans. He then describes a debate between Tolstoy and Dostoevsky over whether morality demands military intervention when a barbarous regime practices widespread torture and massacre. The two novelists pose the issues in ways that shed light on a question still relevant today.
PEACEMAKING, INTERDYNASTIC MARRIAGE, AND THE RISE OF THE FRENCH NOVEL
Authors: Watkins John
Published: April 2016

This article examines the declining prestige and utility of one of the mainstays of pre-Enlightenment peacemaking: treaties uniting once belligerent dynasties through marriage. By the late Middle Ages, interdynastic marriages had become such a common feature of the diplomatic landscape that the practice seemed almost transhistorical, something that was done always and everywhere. By the reign of Louis XIII, however, statesmen began stressing the limits of interdynastic marriage as a diplomatic strategy. This transformation of French affairs of state coincided with the appearance of prose romances that scholars identify retrospectively as the first French novels. This essay focuses on two of the most popular and influential of these novels, César Vichard de Saint-Réal's Dom Carlos (1672) and the Countess of La Fayette's La Princesse de Clèves (1678), as responses to the devaluation of the marriage diplomacy that had established dynastic networks between France and the Mediterranean world for centuries. Both works center on the 1559 Peace of Cateau-Cambrésis between France and Spain, which married Henri II's daughter Elisabeth de Valois to King Philip II. While Saint-Réal does not condemn such arrangements wholesale, he suggests that their success is highly subject to fortune. La Princesse de Clèves owes much to Saint-Réal's portrayal of the personal costs of marriages of state, as well as to Madame de La Fayette's own observations of the French and Savoyard courts. Although her focus on the interior life of her heroine limits explicit political commentary, her allusions to miserably unhappy queens-consort cast marriage diplomacy in an overwhelmingly negative light.
The EZH1–SUZ12 complex positively regulates the transcription of NF-κB target genes through interaction with UXT
Authors: Su Shuai-Kun , Li Chun-Yuan , Lei Pin-Ji , Wang Xiang , Zhao Quan-Yi , Cai Yang , Wang Zhen , Li Lianyun , Wu Min
Published: April 2016

Unlike other members of the polycomb group protein family, EZH1 has been shown to positively associate with active transcription on a genome-wide scale. However, the underlying mechanism for this behavior still remains elusive. Here, we report that EZH1 physically interacts with UXT, a small chaperon-like transcription co-activator. UXT specifically interacts with EZH1 and SUZ12, but not EED. Similar to upon knockdown of UXT, knockdown of EZH1 or SUZ12 through RNA interference in the cell impairs the transcriptional activation of nuclear factor (NF)-κB target genes induced by TNFα. EZH1 deficiency also increases TNFα-induced cell death. Interestingly, chromatin immunoprecipitation and the following next-generation sequencing analysis show that H3K27 mono-, di- and tri-methylation on NF-κB target genes are not affected in EZH1- or UXT-deficient cells. EZH1 also does not affect the translocation of the p65 subunit of NF-κB (also known as RELA) from the cytosol to the nucleus. Instead, EZH1 and SUZ12 regulate the recruitment of p65 and RNA Pol II to target genes. Taken together, our study shows that EZH1 and SUZ12 act as positive regulators for NF-κB signaling and demonstrates that EZH1, SUZ12 and UXT work synergistically to regulate pathway activation in the nucleus.
To the Question of the Tax Debts’ Settlement of Individual Entrepreneurs in the Procedure of Bankruptcy
Authors: Полякова  , Polyakova V.
Published: April 2016

Th e article is devoted to the issues of settlement of tax arrears at diff erent stages, including bankruptcy

proceedings, examined the positive and negative aspects of the new procedure, proposed new tools to improve its effi ciency

in the context of settlement of tax arrears and the rehabilitation of debtors — self-employed individuals.
A real-world evidence study evaluating a treatment for nappy rash
Authors: Goldman Martin , Lodhi Imran
Published: April 2016

This retrospective open study evaluating the efficacy of Sudocrem Antiseptic Healing Cream (SAHC) in infantile nappy rash (NR) was based on real-world evidence collected using an online questionnaire that included Likert scales. Participants who had used SAHC in the past (n=2159) were recruited via social media and email. A total of 1818 respondents who had treated NR in the previous 6 months were asked to take part in the study. Over 50% of respondents saw an improvement in NR on the same day that treatment was started, and within 3 days 94.5% of respondents reported an improvement in NR. Of 1804 subjects who answered the question, 72.5% indicated that the NR had completely healed within 3 days of starting treatment and by the fifth day, 94.7% said that the NR had completely healed. A total of 71% of 1793 respondents said that an episode of NR had either no or minimal impact disrupting their normal lives, but 29% reported a noticeable impact, even though evidence suggests that mild to moderate nappy rash can be treated quickly. Based on this real-world retrospective study, the evidence suggests SAHC is rapidly effective, reduces signs and symptoms of inflammation, and heals NR.
Money: Wali Dad's friends
Authors: Leeper Marion
Published: April 2016

When stories are added to the mix, something interesting happens to early years mathematics. Children begin to explore with their whole selves, and maths becomes a rich playground for open-ended inquiry.
Ácido indolbutírico no enraizamento de mini estacas de roseira
Authors: Pirola Kelli , Dotto Marcelo , Cassol Darcieli Aparecida , Wagner Júnior Américo , Citadin Idemir
Published: April 2016

The roses are considered as the main cut flowers exported from Brazil and also the most popular in the domestic market. Usually, roses can be propagated by grafting or cutting. The aim of this study was to evaluate the cuttings’ size and IBA concentration on mini-cutting rooting of roses variety Mary Rose. Cuttings were obtained from mother plants grown in gardens, with sizes of 3, 5 and 7 cm of length, 1.0 cm in diameter, and treated with IBA, in the concentrations of 0; 500 and 1000 mg L-1. The experimental design was installed in randomized blocks, in a factorial 3 x 3 (mini-cutting sizes x IBA concentration), with 4 repetitions and 10 mini-cuttings per plot. After 60 days rooted cuttings (%), cuttings with callus (%), primary sprouting, leaves and roots numbers, length of the three major roots (cm) and mortality (%) were evaluated. It is recommended to propagate roses by the use of mini-cuttings with 7 cm treated with 500 mg L-1 of IBA.
Multiplicação de bastão-do-imperador em resposta a concentrações de BAP e número de subcultivos
Authors: Santos Eder De Oliveira , Rodrigues Antonio Anderson De Jesus , Silva Esdras Rocha da , Carvalho Ana Cristina Portugal Pinto de
Published: April 2016

The large ornamental potential of tropical flowers has stimulated the commercial cultivation of various species. Micropropagation is a viable alternate method of propagation, since it enables obtaining a higher number of seedlings with uniformity and pathogens free. The objective was to evaluate the in vitro multiplication rate of Etlingera elatior cv. Porcelana, using explants obtained from in vitro established seedling shoots, obtained from the 2nd subcultive. The explants were inoculated in MS culture medium containing different concentrations of BAP (0.0; 2.22; 4.44; 6.66; 8.88; and 11,10 μM), and the cultures maintained in a growth room with temperature 25.0 ± 2.0 °C under a photoperiod of 12 hours of light and light intensity of 30 μmol.m-2 s-1. The multiplication rate was monthly, according to the four subcultives, totaling 120 days. The experimental design was completely randomized, with four replications, analyzed in a factorial 4 x 6. The data were submitted to analysis of variance and regression. There were significant differences in subcultives and made for BAP concentrations used. For the first subcultive, the concentration of 2.22 μM of BAP afforded a rate of 4.06 sprouts per explant, already in the second and fourth subcultives, with the addition of cytokinin concentration was increased amount of sprouts reaching at a rate of 4.05 and 4.96 shoots/explant in the highest concentration of BAP. The results of the treatments evaluated indicate that the presence of BAP favored sprout emission. The concentrations of 2.22, 8.88 and 11.10 μM this cytokinin promoted the highest multiplication rates in the first, second and fourth subcultives, respectively.