bluuebunny/crossref_metadata_2025 huggingface dataset:
A thermohydrodynamic performance analysis of a fluid film bearing considering with geometrical parameters
Authors: DAL Abdurrahim , ŞAHİN Mahir , KILIÇ Mustafa
Published: December 2023

Bearing performance characteristics such as stiffness, and load capacity, are related to the lubrication fluid circulating through the gap. In the fluid film bearings, the characteristic of the lubrication film also depends on the journal geometry and the viscosity. This study aimed to research the bearing geometry influences on the thermohydrodynamic performance of a circular journal bearing. The temperature distribution is modeled using a 3-dimensional energy equation. The velocity components are obtained on the pressure distribution governed by Dowson’s equation. Moreover, the heat transfer between the journal and oil is modeled with Fourier heat conduction equation, and the viscosity equation is derived for SAE10W30 commercial oil as a function of the temperature. An algorithm based on the finite difference method is developed, and a serial simulation is performed for different geometrical parame-ters such as bearing clearance, and bearing length-to-diameter ratio (L/D). When the radial clearance decreases from 150 µm to 100 µm, the maximum pressure grows up by 53%, and the maximum temperature decreases by 21%. On the other hand, when the L/D ratio rises from 0.8 to 1, the maximum pressure grows up by 22%, but the temperature distribution does not significantly change. The load capacity, and the stiffness are higher for low radial clearance. The load capacity, and the stiffness increase when the L/D ratio grows up.
Bridging the Gap: A Case Report of Tooth Replacement using Resin-Bonded Fiber- Reinforced Composite Resin
Authors: Sharma Vineet , Bhansali Sumit , Bhansali Sonal Priya
Published: December 2023

This case report details the prosthetic replacement of a mobile mandibular left central incisor using a Fibre-Reinforced Composite resin (FRC) with a denture tooth pontic along with splinting of periodontally compromised teeth adjacent teeth. FRC is ideal because it offers excellent mechanical and esthetic properties, especially when combined with splinting for periodontally weakened teeth. The clinical procedure included selecting an acrylic denture tooth and bonding it to adjacent teeth using FRC without invasive tooth preparation procedures. The prosthetic tooth was shaped, polished, and finished to blend with the surrounding teeth, providing the patient with proper occlusion and esthetics. The patient experienced no discomfort or adverse effects during the follow-up period, and both the esthetic and functional outcomes were satisfactory. FRC offers a conservative, low-cost alternative to implant prostheses and can improve the patient’s long-term periodontal outcome. However, it is essential to note that regular follow-up visits and proper maintenance are necessary to prolong the lifespan of the restoration.
Sistema de Representações Sociais em sentenças jurídicas de feminicídio na Bahia nos anos de 2020 e 2021
Authors: Feitosa Ellen Araújo Lima , Ferreira Júnior Avimar , Techio Elza Maria
Published: December 2023

O feminicídio é um problema complexo que envolve sucessivas formas de violências nas relações afetivas, acarretando consequências significativas individuais e coletivas. Objetivou-se analisar os sistemas representacionais presentes nos repertórios discursivos em sentenças jurídicas acerca dos casos de feminicídio no estado da Bahia, nos anos de 2020 e 2021. Estudo documental de casos denunciados como feminicídio pelo Ministério Público em 2020/2021 na Bahia, disponíveis na Plataforma Jusbrasil. Foram encontrados 121 documentos, destes, 15 sentenças cumpriram os critérios de inclusão. Estas, foram analisadas mediante a abordagem da Análise de Redes Sociais. Os resultados revelaram diferenças expressivas nas decisões judiciais e em suas fundamentações. Ao comparar os posicionamentos entre juízes e juízas, foi perceptível identificar essas divergências relacionadas ao gênero. Assim, as sentenças foram principalmente ancoradas em justificativas sexistas, materializadas a partir das sentenças no sistema representacional. Dentre estas, motivações do crime como, ciúmes, sentimento de posse e separação.
Electronic Cigarettes on Sperm Quality: Review in Animal and Human Study
Authors: Nahak Teresita Marselina , I Gusti Ngurah Pramesemara
Published: December 2023

Electronic cigarettes that are currently popular are used as nicotine replacement therapy. There are several substances contained in electronic cigarette liquid that have carcinogenic effects. These substances can also increase free radicals which in turn can cause oxidative stress. Nicotine, propylene glycol, and glycerin can cause disturbances in male reproductive function. Infertility can occur due to lifestyle factors, one of which is smoking. Nicotine found in cigarettes can reduce sperm quality, including concentration, mobility, viability, and sperm morphology. The purpose of this study was to determine the effect of electronic cigarettes on sperm quality. The research method uses a literature review system. The twelve studies that are in accordance with the topic of discussion are experimental studies on mice and rats, two studies on human, and one study on both human and rats. Five journals showed a significant decrease in sperm count and testosterone serum level, three other journals showed a significant decrease in sperm morphology and viability, six journals showed a decrease in sperm motility, seven journals showed a significant impairment of testis histological structure, four journals showed a decrease of steroidogenesis enzymes, and one journal showed a significant increase of DNA fragmentation due to the use of electronic cigarettes. Electronic cigarettes had an effect on sperm quality.
Urgensi Pembatasan Waktu Pengujian Perppu Oleh Mahkamah Konstitusi
Authors: Baharuddin Riqiey
Published: December 2023

Abstract
The Constitutional Court as an institution that has received an expansion of authority through court interpretation to review the Perppu against the 1945 Constitution of the Republic of Indonesia was apparently not accompanied by adjustments to the procedural law. Because the object of review of the Perppu and the object of review of laws by the Constitutional Court are two formally different objects. The purpose of this study is to find out and explain what is the urgency of setting the time for reviewing the Perppu by the Constitutional Court. The research method used in this study is a legal research method with a statutory approach. While the legal materials used in this research are primary and secondary legal materials. The results of the study show that, with no time limit for reviewing the Perppu by the Constitutional Court, several petitions for review have lost objects, because the object being tested has turned into law. So the urgency to limit the testing time is to prevent the application from losing the object.
Keywords: Restrictions, Perppu, Constitutional Court.
 
Abstrak
Mahkamah Konstitusi sebagai lembaga yang mendapat perluasan kewenangan melalui penafsiran pengadilan untuk menguji Perppu terhadap UUD NRI Tahun 1945 ternyata tidak dibarengi dengan penyesuaian hukum acaranya. Sebab objek pengujian Perppu dengan objek pengujian undang-undang oleh Mahkamah Konstitusi merupakan dua objek yang berbeda secara formil, sehingga hal itu tidak boleh disamakan ketika diajukan pengujian di Mahkamah Konstitusi. Tujuan dari penelitian ini adalah untuk mengetahui dan menjelaskan apa urgensi diaturnya pembatasan waktu pengujian Perppu oleh Mahkamah Konstitusi. Metode penelitian yang digunakan dalam penelitian ini adalah metode penelitian hukum dengan pendekatan perundang-undangan. Sementara bahan hukum yang digunakan dalam penelitian kali ini adalah bahan hukum primer dan sekunder. Hasil penelitian menunjukkan bahwa, dengan tidak dibatasinya waktu pengujian Perppu oleh Mahkamah Konstitusi membuat beberapa permohonan pengujian telah kehilangan objek, sebab objek yang tengah diuji telah berubah menjadi undang-undang. Sehingga urgensi untuk dibatasinya waktu pengujian ini adalah untuk mencegah permohonan kehilangan objek.
Kata Kunci: Pembatasan, Perppu, Mahkamah Konstitusi
Implikasi Yuridis Terhadap Privasi Akses Pornografi
Authors: Adinda Setyaning Utami
Published: December 2023

Abstract
People who consume pornographic content are more likely to support violence. Law No. 44 of 2008 concerning pornography has been regulated regarding prohibited actions, which are contained in Article 4 - Article 14 of the Pornography Law. Meanwhile, just watching for himself then his act will not be an offense, but if it begins with the activity of downloading pornographic files (and not for himself) then disseminating it is an offense in the provisions in Articles 5 and 6 of the Pornography Law and of course it can. convicted. Therefore, writing focuses on the basis of consideration that a person should not be convicted of accessing pornographic content and the implications that arise as a result of accessing pornographic content, because there are no specific rules that regulate not being allowed to access or watch content that contains pornography, but it is related to privacy rights, free with private life is the government's responsibility as well as to consider binding provisions as a preventive measure in criminal acts due to pornographic content.
Keywords: ; Porn; Criminal Crime; Delict; Privacy, Cyberporn.
 
Abstrak
Orang-orang yang mengonsumsi konten pornografi memiliki sikap cenderung mendukung kekerasan. Undang-Undang No. 44 Tahun 2008 Tentang Pornografi telah diatur mengenai tindakan yang dilarang, yang terdapat dalam Pasal 4 – Pasal 14 UU Pornografi. Sedangkan, menonton saja untuk dirinya sendiri maka perbuatannya itu tidak akan menjadi delik, tetapi jika diawali dengan aktivitas mengunduh file porno (dan tidak untuk dirinya sendiri) kemudian menyebarluaskan itu sudah termasuk delik dalam ketentuan di Pasal 5 dan 6 Undang- Undang Pornografi dan tentu dapat dipidana. Oleh karena itu, penulisan menitikberatkan terhadap dasar pertimbangan tidak dipidananya seseorang mengakses konten pornografi dan implikasi yang muncul akibat mengakses konten pornografi, karena belum ada aturan khusus yang mengatur tentang tidak boleh mengakses atau menonton konten yang bermuatan pornografi, tetapi berkaitan dengan privacy rights, bebas dengan kehidupan pribadi adalah tanggung jawab pemerintah juga untuk memikirkan ketentuan yang mengikat sebagai upaya preventif dalam tindakan kriminal akibat konten pornografi.
Kata kunci : Pornografi; Kejahatan Kriminal; Tindak Pidana; Rahasia; Kejahatan Siber Pornografi
Settlement of Bankruptcy Assets in A Form of Crypto Assets Throughout Bankcruptcy Process
Authors: Hidayatullah Tomi , Subagyono Bambang Sugeng Ariadi , Chumaida Zahry Vandawati , Aditya Kukuh Leksono Suminaring
Published: December 2023

AbstractThis research analyzes Crypto Assets as bankruptcy assets in the procedures for settlement by the curator in relation to statutory regulations, as well as the criteria for objects that can be included in bankruptcy assets. Generally, wealth is in the form of objects that can be seen, but the emergence of Crypto Assets in society breaks the stigma that exists in general. Based on bankruptcy practices in Indonesia, the categories or characteristics of objects that can be included as bankruptcy assets belonging to debtors are object that have resale value or economic value. This research is juridical-normative in nature. The results of this research show that crypto assets have met the classification as intangible objects. As bankruptcy assets, Crypto Assets cannot necessarily be used as a means of paying debts to creditors, because in Indonesia Crypto Assets are only allowed as an investment tool. However, Crypto Assets as bankruptcy assets must first be cleared by the curator until they are in the form of rupiah currency through certain stages in accordance with applicable law and regulations.Keywords: Bankruptcy; Bankruptcy Assets; Crypto Assets; Settlement.
Vector-Borne Zoonotic Lymphadenitis – the Causative Agents, Epidemiology, Diagnostic Approach and Therapeutic Possibilities – An Overview
Authors: Oršolić Martina , Bogdanić Nikolina , Balen Topić Mirjana
Published: December 2023

Besides common skin pathogens, acute focal lymphadenitis in humans can be caused by a zoonotic pathogen in rare cases. Furthermore, it can develop in absence of any direct or indirect contact with infected animal in cases when the microorganism is transmitted by vector. This clinical entity is rare, and therefore not easily recognized in most regions, yet many zoonotic illnesses are considered emerging or re-emerging nowadays. Focal zoonotic vector-borne lymphadenitis and its numerous causative agents with their variegated clinical manifestations have been described in some case reports and small case series. Therefore, we tried to summarize those data in this narrative overview, with the aim to rise clinical awareness, which could improve clinical outcomes. This overview briefly covers reported pathogens, their vectors and geographic distribution, as well as their main clinical manifestations, diagnostic possibilities and recommended therapy. Vector-borne tularemia, plague, bartonellosis, rickettsioses, borreliosis and Malayan filariasis are mentioned. According to the existing data, when acute focal bacterial vector-borne zoonotic lymphadenitis is suspected, in severe or complicated cases it seems prudent to apply combined aminoglycoside (or quinolone) plus doxycycline as an empirical therapy, pending definite diagnostic results. In this field the „one health approach” and further epidemiological and clinical studies are needed.
Molecular Basis of Mullerian Agenesis Causing Congenital Uterine Factor Subfertility- a Systematic Review
Authors: Dube Rajani , Kar Subhranshu Sekhar , Jhancy Malay , George Biji Thomas
Published: December 2023

Abstract: Infertility affects around 1 in 5 couples in the world. Congenital absence of the uterus results in absolute infertility in females. Mullerian agenesis(MA) is the nondevelopment of the uterus. Mayer-Rokitansky-Küster-Hauser(MRKH) syndrome is a condition of uterovaginal agenesis in the presence of normal ovaries and 46 XX Karyotype. With the advancement of re-productive techniques, having a biological offspring in women with MA is possible. The exact etiology of MA is unknown although several genes and mechanisms affect the development of Mullerian ducts. Through this systematic review of the available literature, we searched for the genetic basis of MA. The aims included identification of the genes, chromosomal locations, changes responsible for MA, and fertility options, in order to offer proper management and counseling to these women with MA. A total of 85 studies were identified through searches. Most of the studies identified multiple genes at various locations although the commonest in-volved chromosomes 1, 17, and 22. There is also conflicting evidence of the involvement of var-ious candidate genes in the studies. The etiology of MA seems to be multifactorial and complex involving multiple genes, and mechanisms including various mutations and mosaicism.
Ultrafiltration Harvesting of Microalgae Culture Cultivated in a WRRF: Long-Term Performance and Techno-Economic and Carbon Footprint Assessment
Authors: Mora-Sánchez Juan Francisco , González-Camejo Josué , Noriega-Hevia Guillermo , Seco Aurora , Ruano Maria Victoria
Published: December 2023

A cross-flow ultrafiltration harvesting system of a pre-concentrated microalgae culture was tested in an innovative anaerobic-based WRRF. The microalgae culture was cultivated in a membrane photobioreactor fed with the effluent from an anaerobic membrane bioreactor treating sewage. These harvested microalgae biomass was then anaerobically co-digested with primary and secondary sludge from the water line. Depending on the needs of this anaerobic co-digestion, the filtration harvesting process was evaluated intermittently over a period of 212 days for different operating conditions, mainly the total amount of microalgae biomass harvested and the desired final total solids concentration (up to 15.9 g·L1 with an average of 9.7 g·L1). Concentration ratios of 15-27 were obtained with average transmembrane fluxes ranged from 5 to 28 L·m2·h1. Regarding membrane cleaning, both backflushing and chemical cleaning resulted in transmembrane flux recoveries that were, on average, 21% higher than those achieved with backflushing alone. The carbon footprint assessment shows promising results as the GHG emissions associated with the cross-flow ultrafiltration harvesting process could be less than the emissions savings associated with the energy recovered from the biogas production from the anaerobic valorisation of the harvested microalgae.
Thermodynamically spontaneously intercalated crystal H3O+ enables long-lasting LiMn2O4 cathodes with enhanced proton tolerance in aqueous battery chemistry
Authors: Zhu Junwu , Huang Jiangfeng , Xue Liang , Huang Yin , Jiang Yanchen , Wu Ping , Fan Xiulin
Published: December 2023

LiMn2O4 (LMO) is an attractive and inexpensive green cathode material for aqueous lithium-ion batteries (ALIBs), but its inferior cycle performance limits the practical application. The degradation mechanism of LMO in ALIBs is still unclear, resulting in the inability to improve its structural stability and achieve a breakthrough in cycle life. The electrode/electrolyte interface is believed to play an important role in electrode degradation. However, the interactions of the water-containing electrode/electrolyte interface of LMO are underexplored. To reveal the interaction mechanism and construct a conceptual framework for extensive studies, we demonstrate for the first time the insertion of H3O+ into LMO during cycling in aqueous electrolyte and elucidate the paradoxical effects of H3O+. The crystal H3O+ enhances the structural stability of LMO by forming a gradient Mn4+-rich protective shell, but an excess amount of crystal H3O+ leads to poor Li+ conductivity in LMO, resulting in rapid capacity fading. Combining electrochemical analyses, structural characterizations, and first-principles calculations, we reveal the intercalation of H3O+ into LMO and its associated mechanism on the structural evolution of LMO. Furthermore, we propose to regulate the crystal H3O+ content in LMO by modifying the hydrogen bond networks of aqueous electrolyte to restrict H2O molecule activity. This approach utilizes an appropriate amount of crystal H3O+ to enhance the structural stability of LMO while maintaining sufficient Li+ diffusion. This study will facilitate the development of advanced ALIBs with extended lifespan and enhanced energy density.
Responses of phyllosphere microbiota and plant health to application of Bordeaux Mixture
Authors: Ye Guo , Wang Hancheng , Li Tong , Wang Feng , Xu Benbo
Published: December 2023

To investigate the ecological effects of fungicides on tobacco target spot, a field experiment was conducted to investigate the control efficacy at 3 and 9 days after spraying 80% Bordeaux Mixture and the effect on the phyllosphere microbial communities of tobacco leaves at different persistence periods of the fungicide through high-throughput sequencing. The results showed that Bordeaux Mixture had remarkable control effects against tobacco target spot at the beginning, but showed powerless control effects at the late stage of application. Bordeaux Mixture had significant effects on the phyllosphere microbial communities of tobacco leaves. Compared with the diseased group, the healthy group had a richer species diversity in fungal community structure before application. After application, the diversity of microbial community on diseased leaves increased over time and the abundance of the pathogen Thanatephorus decreased (79.35%) significantly. And the function prediction showed that the relative abundance of “pathotroph” fungal communities decreased after Bordeaux Mixture application. Tobacco target spot had changed the microbial community structure with lower diversity and higher relative abundance of pathogen, after treatment of Bordeaux Mixture, the diversity of community was increasing and the relative abundance of pathogen was decreasing significantly over time.
Dual Cluster-Head Protocol for Limited-Resource Networks within the Internet of Things Using K-Means Machine Learning and Considering Energy Harvesting Capability
Authors: OUKAS Nourredine , HABOUSSI Samia , ABBAS Akli , TELLAB Mohamed Elamine , LOUNIS Tarek
Published: December 2023

This paper introduces a novel protocol named the Dual Cluster Heads Routing Protocol (noted DCHRP) designed for the autonomous organization of networks with limited resources within the context of the Internet of Things (IoT). The proposed methodology employs K-MEANS machine learning to partition the wireless network into K clusters and establishes two leaders within each cluster. This strategy aims to minimize energy consumption and evenly distribute the workload across the entire network. It is assumed that the network's nodes possess the capability to harness renewable ambient energy for battery recharging. Two versions of DCHRP are presented: the first one (DCHRP-K5) involves segmenting the network into K clusters, where K is set at 5% of the total node count. The second version (DCHRP-K10) maintains a fixed cluster count at 10%. Experimental evaluations conducted using the NS3 simulator demonstrate the capacity of the proposed approach to extend the operational lifespan of such networks. The outcomes of these experiments substantiate the efficacy of both DCHRP versions and their superiority over alternative methodologies such as LEACH and K-LEACH. Furthermore, DCHRP-K10 exhibits superior performance compared to DCHRP-K5.
Severe Intrauterine Adhesions Following Modified B-Lynch Procedure: A Case Report
Authors: Feng Ye , Bi Hui
Published: December 2023

Background
B-Lynch suture is a highly effective procedure for controlling uterine bleeding due to uterine atony. Recently, various modifications of the B-Lynch suture have been developed, but evidence of these procedures’ safety and efficacy is still not enough.
Case presentation: We reported a 30 years old female patient who underwent cesarean section and modified B-Lynch procedure because of uterine atony and refractory postpartum hemorrhage one year ago. During the surgery, the classic B-Lynch suture was initially applied to the uterus, and then No. 1 absorbable suture tightly encircled the uterine body, passing through the avascular area of the broad ligament below the round ligament, and was knotted at the anterior of the uterus. The patient experienced a significant reduction in menstrual flow after the surgery. Due to the patient's desire to have children, she underwent hysteroscopy and laparoscopy, which revealed severe intrauterine adhesions in the upper portion of the uterus. The patient's fertility was severely compromised.
Conclusions
The safety and effectiveness of uterine compression suture techniques still require further investigation. Obstetricians should exercise caution when selecting uterine compression suture procedures for patients with refractory postpartum hemorrhage and avoid excessive sutures to protect the patient's fertility.
Tolerability Assessment of Tyrosine Kinase Inhibitors in Patients with Solid Tumor Malignancies and Hypoalbuminemia
Authors: Sadrameli Sarvnaz , Bringgold Sydney , Dow-Hillgartner Elizabeth
Published: December 2023

Background: Hypoalbuminemia is common in patients with advanced solid tumor malignancies, where there is an increased unbound fraction of highly protein-bound drugs, potentially leading to higher free drug concentration exposure and more toxicities. Despite the increased use of highly protein-bound tyrosine kinase inhibitors (TKIs) in cancer treatments over the decades, the tolerability of these agents in patients with hypoalbuminemia is not fully known. Our aim is to assess whether patients on oral TKIs with hypoalbuminemia are at higher risk for experiencing medication-related adverse events, therefore requiring careful considerations.
Materials and Methods: This is a single-center, retrospective study including patients ≥ 18 years of age with a solid tumor malignancy who had taken at least one dose of oral TKIs with a protein binding of ≥ 90% between 06/01/2016 and 06/01/2021.
Results: Patients with hypoalbuminemia had shorter time on treatment (median Kaplan-Meier (KM) estimate: 2.8 months (95 % CI 2.3–4.5 months) vs. 4.3 months (95 % CI 2.8 –6.4 months), p=0.003) compared to those without hypoalbuminemia. In patients who had TKI discontinuation, dose reduction was associated with longer time on treatment in patients in the normal albumin group compared to patients in the hypoalbuminemia group or patients without dose reduction (p<0.0001). Patients in the hypoalbuminemia group experienced significantly more grade 3/4 adverse events compared to those in the normal albumin group (73% vs. 27%, p<0.0001).
Conclusion: Hypoalbuminemia is a risk factor for shorter time on treatment in patients with solid tumor malignancies, when taking highly protein-bound oral TKIs.
Zika Virus NS1 Drives Tunneling Nanotube Formation for Mitochondrial Transfer, Enhanced Survival, Interferon Evasion, and Stealth Transmission in Trophoblasts
Authors: Michita Rafael T. , Tran Long B. , Bark Steven J. , Kumar Deepak , Toner Shay A. , Jose Joyce , Mysorekar Indira U. , Narayanan Anoop
Published: December 2023

Zika virus (ZIKV) infection continues to pose a significant public health concern due to limited available preventive measures and treatments. ZIKV is unique among flaviviruses in its vertical transmission capacity (i.e., transmission from mother to fetus) yet the underlying mechanisms remain incompletely understood. Here, we show that both African and Asian lineages of ZIKV induce tunneling nanotubes (TNTs) in placental trophoblasts and multiple other mammalian cell types. Amongst investigated flaviviruses, only ZIKV strains trigger TNTs. We show that ZIKV-induced TNTs facilitate transfer of viral particles, proteins, and RNA to neighboring uninfected cells. ZIKV TNT formation is driven exclusively via its non-structural protein 1 (NS1); specifically, the N-terminal region (50 aa) of membrane-bound NS1 is necessary and sufficient for triggering TNT formation in host cells. Using affinity purification-mass spectrometry of cells infected with wild-type NS1 or non-TNT forming NS1 (pNS1ΔTNT) proteins, we found mitochondrial proteins are dominant NS1-interacting partners, consistent with the elevated mitochondrial mass we observed in infected trophoblasts. We demonstrate that mitochondria are siphoned via TNTs from healthy to ZIKV-infected cells, both homotypically and heterotypically, and inhibition of mitochondrial respiration reduced viral replication in trophoblast cells. Finally, ZIKV strains lacking TNT capabilities due to mutant NS1 elicited a robust antiviral IFN-λ 1/2/3 response, indicating ZIKV's TNT-mediated trafficking also allows ZIKV cell-cell transmission that is camouflaged from host defenses. Together, our findings identify a new stealth mechanism that ZIKV employs for intercellular spread among placental trophoblasts, evasion of antiviral interferon response, and the hijacking of mitochondria to augment its propagation and survival. Discerning the mechanisms of ZIKV intercellular strategies offers a basis for novel therapeutic developments targeting these interactions to limit its dissemination.
Perception and Effectiveness of Moodle Learning Management System (LMS) in Creating Engaging Learning Environments: A Study of West African Universities
Authors: Olugbade Damola
Published: December 2023

This study surveyed 51 lecturers from 11 universities in Ghana and Nigeria to gauge their perceptions of Moodle Learning Management System's (LMS) ability to create engaging learning environments within the PEBL West Africa program. Participants from diverse academic backgrounds were selected through convenience sampling. Using an online survey based on the Technology Acceptance Model (TAM), the research covered multiple facets of Moodle. Analysis included descriptive statistics and advanced methods, revealing consistently positive views across demographics. Lecturers' positive perceptions of Moodle correlated with its efficacy in promoting learner engagement. Implications highlight Moodle's pivotal role in enhancing teaching and learning experiences in West African universities. Emphasizing ongoing support for educators is crucial to maximizing Moodle's potential. This study provides valuable insights for educators, administrators, and policymakers, guiding efforts to improve blended learning practices. Future research can explore strategies to further leverage Moodle's potential for enhanced learner engagement and improved academic outcomes in the region.
Single-cell and genome-wide Mendelian randomization identifies causative genes for gout
Authors: yang yubiao , Hu Ping , Zhang Qinnan , Ma Boyuan , Chen Jinyu , Wang Bitao , ma Jun , Liu Derong , Hao Jian , Zhou Xianhu
Published: December 2023

Background Gout is a prevalent manifestation of metabolic osteoarthritis induced by elevated blood uric acid levels. The purpose of this study was to investigate the mechanisms of gene expression regulation in gout disease and elucidate its pathogenesis. Methods The study integrated gout genome-wide association study (GWAS) data, single-cell transcriptomics (scRNA-seq), expression quantitative trait loci (eQTL), and methylation quantitative trait loci (mQTL) data for analysis, and utilized two-sample Mendelian randomization study to comprehend the causal relationship between proteins and gout. Results We identified 17 association signals for gout at unique genetic loci, including four genes related by protein-protein interaction network (PPI) analysis: TRIM46, THBS3, MTX1, and KRTCAP2. Additionally, we discerned 22 methylation sites in relation to gout. The study also found that genes such as TRIM46, MAP3K11, KRTCAP2, and TM7SF2 could potentially elevate the risk of gout. Through a Mendelian randomization (MR) analysis, we identified three proteins causally associated with gout: ADH1B, BMP1, and HIST1H3A. Conclusion According to our findings, gout is linked with the expression and function of particular genes and proteins. These genes and proteins have the potential to function as novel diagnostic and therapeutic targets for gout. These discoveries shed new light on the pathological mechanisms of gout and clear the way for future research on this condition.
Understanding Treatment Preferences and Cognitive Outcomes in Patients with Gliomas
Authors: Succop Benjamin , Richardson Daniel R. , Rauf Yasmeen , Higgins Dominique , Catalino Michael
Published: December 2023

Objective: Understanding how glioma patients value specific cognitive outcomes is essential to personalizing their treatment plans. The purpose of this study was to identify the modifiable cognitive functions most affected by treatment and most important to patient quality of life.
Methods:
Patients with gliomas were prospectively enrolled in focus groups and individual interviews guided by a standardized guide focused on cognitive functions. Patient values and treatment preferences were elicited and compared to the frequency of reported deficits. NVivo natural language processing software was used to perform thematic analyses on qualitative data.
Results:
Twenty participants participated, of whom 60% were female. Racial identification consisted of 75% White, 15% Black/African American, and 10% other. The cognitive functions most essential to the quality of life in this cohort were a sense of self (80% of participants), memory (70% of participants), and communication (25% of participants). The functions that experienced the most deficits because of treatment were memory (65% of participants), concentration (65% of participants), and special senses (40% of participants). “Dealbreakers” to treatment were complete loss of independence, sense of self, and/or ability to interact with loved ones.
Conclusions:
Glioma patients in this study prioritized cognitive functions according to intrinsic values, personal identity, and their ability to interact with loved ones. For this cohort, memory, sense of self, and communication were most highly valued by patients. The next phase of this study will investigate the relative survival value of these key functions using patient preference elicitation to optimize surgical decision-making.
Comparison of Isothermal Oxidation Performance of IN 939 Produced by Casting and Additive Manufacturing
Authors: Başbozkurt Batuhan , Sarıoğlu Cevat
Published: December 2023

The focus of this study is to compare the isothermal oxidation behavior of IN 939 nickel-based superalloys manufactured by powder bed fusion (PBF) and casting methods. Oxidation experiments were performed on heat treated and non-heat treated IN 939 specimens to reveal the role of heat treatment and manufacturing methods on oxidation behavior. Microstructure of as cast IN 939 had a dendritic structure with gamma prime precipitates. After heat treatment two kinds of gamma prime precipitates were visible. IN 939 manufactured by Powder bed fusion exhibited clearly visible melt pools and no trace of gamma prime precipitates. After heat treatment the melt pools disappeared, and gamma prime precipitates formed. Weight gain results showed that all samples experienced similar mass gain characteristics however, PBF IN 939 with heat treatment showed slightly superior spallation behavior than other samples at 1000˚C. Spallation did not occur at 800 and 900˚C whereas at 1000˚C all samples experienced spallation. All samples followed a parabolic rate law. The activation energies of all samples, calculated for three temperatures (800, 900 and 1000˚C,) were similar, ranging between 260.99-287.51 kJ/mole. XRD and EDS analyses were performed to investigate the oxidation products on the surface. Results indicated that the oxide scale that formed on all IN 939 samples were mainly Cr2O3 and TiO2 in rutile form. In conclusion, based on oxidation weight gain (kinetics) results and oxide scale analysis, additively manufactured IN939 superalloys showed similar oxidation resistance compared to as cast IN939 alloy. These results supported the replacement of as cast manufacturing technique with additive manufacturing techniques for IN 939 alloys with respect to high temperature oxidation resistance.
Quantization of linear acoustic and elastic wave models in characterizations of isomorphism
Authors: Yang Chen
Published: December 2023

From the macroscopic to the microscopic world, quantum mechanical effects in acoustics and elastic waves have become increasingly important. Observations on the quantum effects of acoustic and elastic waves using experimental methods have been reported in the literature. However, the conventional formulations of acoustic and elastic waves are still mainly governed by classical models. In this study, we investigated the quantization of acoustic and elastic waves using generalized Lorenz gauges. The potential variables of acoustic and elastic waves can be quantized in a manner similar to that of electrodynamics. The results include the Schrödinger equation with minimal coupling between the field and particles. The quantization of field variables is established as a consequence of the gauge symmetry property of the Schrödinger equation. Later, we explored the connections between the parallel formulations of mechanics and waves through an algebraic aspect. This highlights the isomorphism pattern from the characterization of parallel formulations. To support the results, the derivations of potential formulations based on Lorenz gauges and functional mapping between field variables are presented.
Effect of the mass vaccination duration on the spread of COVID-19 evaluated by a flexible compartment model
Authors: Ohmori Hiroo
Published: December 2023

For COVID-19, infected individuals are isolated from the community when they become symptomatic, and when they become the recovered individuals who have immunity, they return to the community. With increase in the number of recovered individuals in the community, the contact rate between infected individuals and susceptible individuals is reduced, resulting in a decrease in the number of infected individuals. Vaccination causes not only a decrease in the number of susceptible individuals in the community but also a reduction in the contact rate between infected individuals and susceptible individuals with an increase in the number of vaccinated individuals as the recovered individuals do. From a viewpoint of herd immunity, the vaccination duration, which is the period between the start and the end of mass vaccination, must need to be examined because the number of vaccinated individuals actually increases gradually day by day according to vaccination programs and the total number of vaccinated individuals depends on the mass vaccination duration, controlling the spread of COVID-19. How long should we continue the mass vaccination to contain COVID-19 pandemic by a physical viewpoint? The number of infected individuals by different mass vaccination durations is calculated by a flexible compartment model specific to COVID-19. The model contains the vaccination rate as an independent valuable in the calculation equations and, as the dependent valuables, the number of isolated/recovered individuals and the population excluding the individuals kept in isolation, both of which affect the contact rate between infected individuals and susceptible individuals. The effect of the mass vaccination duration can be evaluated by comparing the total numbers of infected individuals among the cases with different mass vaccination durations for the cases with different start-date of vaccination, with different vaccination rate and with different symptomatic rate. The results show that, since the contact rate decreases with an increase in the vaccinated individuals, the earlier the start-date of vaccination is, the smaller the total number of infected individuals becomes, and the longer the mass vaccination duration is, the smaller the total number of infected individuals becomes. The results also show that, when vaccination is continued until the day when the sum of the number of recovered individuals and the number of vaccinated individuals becomes more than an ‘expedient herd immunity threshold’, the total number of infected individuals is significantly reduced and the duration of infection is also markedly shortened as expected for the case with a sufficient mass vaccination duration.
Codebase release 2.2 for HEJ
Authors: Andersen Jeppe R. , Ducloué Bertrand , Elrick Conor , Hassan Hitham , Maier Andreas , Nail Graeme , Paltrinieri Jérémy , Papaefstathiou Andreas , Smillie Jennifer M.
Published: December 2023

We present version 2.2 of the High Energy Jets (HEJ) Monte Carlo event generator for hadronic scattering processes at high energies. The new version adds support for two further processes of central phenomenological interest, namely the production of a W boson pair with equal charge together with two or more jets and the production of a Higgs boson with at least one jet. Furthermore, a new prediction for charged lepton pair production with high jet multiplicities is provided in the high-energy limit. The accuracy of HEJ 2.2 can be increased further through an enhanced interface to standard predictions based on conventional perturbation theory. We describe all improvements and provide extensive usage examples. HEJ 2.2 can be obtained from https://hej.hepforge.org.
A clinical case of viral myocarditis associated with sars-cov-2 in a health worker
Authors: Babanov S. A. , Azovskova T. A. , Lavrentyeva N. E. , Baraeva R. A.
Published: December 2023

The study of various pathological conditions associated with COVID-19 remains an urgent task. In occupational medicine, COVID-19 is considered as a new biological factor that can occur not only in the environment, but also in production conditions. Medical workers are at an increased risk of infection with the SARS-CoV-2 virus when performing their professional duties, while a new coronavirus infection can be considered as an occupational disease. The presence of severe complications of a new coronavirus infection leading to disability gives relevance to the analysis of the features of occupational diseases of medical workers in order to improve their diagnosis, improve prevention, treatment and rehabilitation. The most important manifestation of a new coronavirus infection is a lesion of the cardiovascular system, one of the possible variants of which may be the development of myocarditis. In the Samara region in 2021–2022, 10 cases of chronic occupational diseases associated with a new coronavirus infection that caused permanent disability were identified to medical workers. Of these, viral myocarditis was diagnosed in four cases and inflammatory dilated cardiomyopathy in one case. The presented clinical case reflects one of the possible serious complications of coronavirus infection – myocarditis, which led to the development of cardiac arrhythmias. The article presents the principles and results of a medical examination conducted in order to establish a causal relationship of the disease with the professional activity of a medical worker. The need for a multidisciplinary approach to the diagnosis of manifestations, treatment of COVID-19 and its complications, with the mandatory participation of a cardiologist, improvement of the examination of the connection of COVID-19 with the profession and admission to work in conditions of high risk of infection with SARS-CoV-2 medical workers is emphasized.
Acompañamiento de padres y madres en el aprendizaje de sus hijos e hijas
Authors: Hernández Pulido Carolina Elizabeth , Pineda Castillo Kristian Armando
Published: December 2023

En el presente artículo se aborda el papel que desempeñaron los padres y las madres de familia durante y después del encierro social por la pandemia por coronavirus. El objetivo es describir el acompañamiento de padres y madres en el aprendizaje de estudiantes de tercer grado de educación primaria durante el confinamiento y posconfinamiento. Para la investigación, se siguió un enfoque mixto de conversión, que combina datos cualitativos y cuantitativos, recurriendo al método de estudio de casos múltiple. Los resultados revelan que los padres y las madres brindaron apoyo a los educandos al crear espacios de estudio, fomentar la autonomía de éstos, realizar visitas a la escuela y mantener comunicación constante con docentes; mientras otros se rezagaban a consecuencia de la brecha digital y la falta de compromiso de padres y madres. Entre las conclusiones, se considera que la compañía del familiar tiene un papel preponderante en situaciones que obligan a la sociedad a continuar con el proceso formativo desde casa.
Combining the me Thods of Smallholders Land Capture by Officials of the Central Chernozem Region from the Second half of XVII by the end of XVIII Century
Authors: Kudlanov K. B.
Published: December 2023

Relevance. The volume of redistribution of the smallholder land fund directly depended on the success of combining the methods of land seizures by officials. For the one-courtyard people of the Central Chernozem region, the voiced question was so relevant that it significantly influenced their property status and choice of habitat.

Purpose. The study of a combination of various methods of capturing one-courtyard people's land by officials of the Central Chernozem region from the middle of XVII-th to the end of XVIII-th century.

Objectives consist of the study of individual and successive methods of seizing smallholder land by officials, as well as reusable land acquisitions by individuals upcoming «in business» together with their direct descendants.

Methodology. In the process of the work were used analytical-synthetic and comparative-historical methods, as well as retrospective and historiographical analyses.

Results. In the study, the author shows the whole structure of the methods of seizing one-courtyard people's land by officials, providing a statistical comparison of their application in practice. Then the researcher studies of the combined use of different methods of possession, which alternate at all levels (subtypes, types, and methods) for success. Finally, the author examines the multiple acquisitions of smallholder land by officials, along with their collective seizures by entire clans.

Conclusion. The reason for combining the methods of capture lay in the steadfastness of the one-courtyard people and the greed of individual officials. The cessation of a series of attempts to seize the land was determined by the success of one side or another. The variety of combinations of methods depended on both officials and onecourtyard people. For example, the characters of the invader and the victim. The versatility of possessions expanded with the powers of the upcoming «in business» in progression: the higher the position, the wider the list of its capabilities, and the lower the level of the invader, the more rudely he applied the methods of seizures. On the whole, the process of redistributing the land fund of the one-courtyard people of the Central Chernozem region was not an individual phenomenon, since it involved several generations of all parties involved in the process.
National Policy of Russia at Different Stages of State Development: Historical and Legal Aspect
Authors: Petrishcheva N. S. , Zarubina K. A. , Chapchikov S. Y.
Published: December 2023

Relevance. The Russian Federation is a multinational and multi–confessional country with more than a thousand years of development experience. According to some statistical studies, currently representatives of more than 200 nationalities live in the Russian state, having their own distinctive, unique culture, linguistic, ethnic characteristics. The multiethnic composition of the population of the modern Russian state necessitates the development of an effective legal mechanism for regulating the national issue in the country. However, it is impossible to achieve this goal without a comprehensive study of the historical foundations of the evolution of state national policy in Russia. In this connection, we consider it relevant to analyze the legislative experience of regulating interethnic relations in the Russian state, which has the status of a multi-confessional and multinational country at all stages of its development.

The purpose of the study is a historical and legal analysis of the evolution of the national state policy of Russia in the context of changes in society and the state at different stages of historical development.

Objectives: to identify the features of the legal regulation of interethnic relations in Russia in the prerevolutionary period; to analyze the experience of solving the national question in the USSR; to determine the main goals of the implementation of national state policy in the Russian Federation and priorities of legal national policy at the present stage of development of the Russian state.

Methodology. In the process of working on the study, the following methods were used: the method of synthesis, analysis, generalization, systematization, comparative legal and chronological methods.

The results of the study have important theoretical and practical significance. The conclusions obtained in the work are able to enrich the legal science with new knowledge of the sphere, as well as find application in the further improvement of the domestic national state policy.

Conclusion. Currently, Russia has developed a systematic approach to solving the national issue, legal mechanisms for regulating interethnic relations have been developed, taking into account the centuries-old experience of the history of Russia's development, which has the status of a multinational country at all stages of the evolution of statehood.