bluuebunny/crossref_metadata_2025 huggingface dataset:
Elucidating the Effects of Ionizing Radiation on Immune Cell Populations: A Mathematical Modeling Approach with Special Emphasis on Fractional Derivatives
Authors: Alzahrani Dalal Yahya , Siam Fuaada Mohd , Abdullah Farah A.
Published: April 2023

Despite recent advances in the mathematical modeling of biological processes and real-world situations raised in the day-to-day life phase, some phenomena such as immune cell populations remain poorly understood. The mathematical modeling of complex phenomena such as immune cell populations using nonlinear differential equations seems to be a quite promising and appropriate tool to model such complex and nonlinear phenomena. Fractional differential equations have recently gained a significant deal of attention and demonstrated their relevance in modeling real phenomena rather than their counterpart, classical (integer) derivative differential equations. We report in this paper a mathematical approach susceptible to answering some relevant questions regarding the side effects of ionizing radiation (IR) on DNA with a particular focus on double-strand breaks (DSBs), leading to the destruction of the cell population. A theoretical elucidation of the population memory was carried out within the framework of fractional differential equations (FODEs). Using FODEs, the mathematical approach presented herein ensures connections between fractional calculus and the nonlocal feature of the fractional order of immune cell populations by taking into account the memory trace and genetic qualities that are capable of integrating all previous actions and considering the system’s long-term history. An illustration of both fractional modeling, which provides an excellent framework for the description of memory and hereditary properties of immune cell populations, is elucidated. The mathematics presented in this research hold promise for modeling real-life phenomena and paves the way for obtaining accurate model parameters resulting from the mathematical modeling. Finally, the numerical simulations are conducted for the analytical approach presented herein to elucidate the effect of various parameters that govern the influence of ionizing irradiation on DNA in immune cell populations as well as the evolution of cell population dynamics, and the results are presented using plots and contrasted with previous theoretical findings.
Fracture Kinetics and Mechanisms of Ultrafine-Grained Materials during Fatigue Tests in the Low-Cycle Fatigue Region
Authors: Klevtsov Gennadiy V. , Valiev Ruslan Z. , Klevtsova Natal’ya A. , Tyurkov Maksim N. , Pigaleva Irina N. , Aksenov Denis A.
Published: April 2023

In this paper, the fracture kinetics and mechanisms in the low-cycle fatigue region were analyzed for different ultrafine-grained (UFG) materials with body-centered cubic (bcc), hexagonal close-packed (hcp) and face-centered cubic (fcc) lattices. Three-point bending principle fatigue tests were performed. The tests show that the UFG structure formation in the investigated materials has an ambiguous effect on the total number of cycles to failure (life) of the samples. The number of cycles to fatigue crack initiation (Nin) is about 20% of the total life of the samples, irrespective of the material state and the crystal lattice type. At the same value of the stress intensity coefficient range (∆K), for the majority of the investigated UFG materials, the fatigue crack propagation rate (dl/dN) is close to or lower than that of the initial coarse-grained (CG) materials. For the UFG materials, the coefficient n in the Paris equation is, in most cases, lower than that for the CG materials, which indicates that the UFG materials are less sensitive to cyclic overload. The fatigue fracture mechanisms of the investigated CG and UFG materials are rather similar, although the fracture of the UFG materials is accompanied by the formation of many secondary cracks, irrespective of the crystal lattice type.
Organic Aciduria Disorders in Pregnancy: An Overview of Metabolic Considerations
Authors: Shakerdi Loai A. , Gillman Barbara , Corcoran Emma , McNulty Jenny , Treacy Eileen P.
Published: April 2023

Organic acidurias are a heterogeneous group of rare inherited metabolic disorders (IMDs) caused by a deficiency of an enzyme or a transport protein involved in the intermediary metabolic pathways. These enzymatic defects lead to an accumulation of organic acids in different tissues and their subsequent excretion in urine. Organic acidurias include maple syrup urine disease, propionic aciduria, methylmalonic aciduria, isovaleric aciduria, and glutaric aciduria type 1. Clinical features vary between different organic acid disorders and may present with severe complications. An increasing number of women with rare IMDs are reporting successful pregnancy outcomes. Normal pregnancy causes profound anatomical, biochemical and physiological changes. Significant changes in metabolism and nutritional requirements take place during different stages of pregnancy in IMDs. Foetal demands increase with the progression of pregnancy, representing a challenging biological stressor in patients with organic acidurias as well as catabolic states post-delivery. In this work, we present an overview of metabolic considerations for pregnancy in patients with organic acidurias.
Research on the High Light Out-Coupling Efficiency Deep-Blue Top-Emitting Organic Light-Emitting Diode through FDTD Optical Simulation
Authors: Pan Saihu , Hu Suhao , Wei Bin
Published: April 2023

We have studied high light out-coupling efficiency top-emitting organic light-emitting diodes (TOLEDs) under the guidance of the finite-difference time-domain (FDTD) simulation. TOLED achieves an extraordinarily high light extraction efficiency at 468 nm, in deep-blue regions, of 49.70%, which is approximately 3.5 times that of the bottom light-emitting diode (BOLED) by changing the thickness of the organic layer and the position of the light-emitting layer in the FDTD simulation. Based on the simulation results, the TOLED with ultrahigh efficiency and narrow full width at half maximum is successfully fabricated, and the maximum external quantum efficiency of TOLED is almost 3.3 times that of the BOLED, which is perfectly consistent with the FDTD simulation results. Meanwhile, the shift of the electroluminescence spectrum of the TOLED is restricted within 10° in the angular-dependence test (0° to 80°). The optimized performance of the OLED indicates a new method to develop a high-performance device under the guidance of simulation.
Structure of the Charge-Transfer State in PM6/Y6 and PM6/Y6:YT Composites Studied by Electron Spin Echo Technique
Authors: Lukina Ekaterina A. , Kulikova Aina V. , Uvarov Mikhail N. , Popov Alexander A. , Liu Ming , Zhang Yong , Kulik Leonid V.
Published: April 2023

Nowadays, Y-shaped non-fullerene acceptors become increasingly important in organic photovoltaics (OPV). Their use in binary and ternary bulk heterojunction composites continuously pushes up the efficiency of OPV devices. However, the mechanism of OPV performance enhancement by the third component of a ternary composite is rarely understood. In the present work, pulse EPR technique was used to reveal the similarities and the differences of photoinduced charge separation process in binary PM6/Y6 and ternary PM6/Y6:Y-T composites, where PM6 is polymer donor, Y6 and Y-T are different non-fullerene acceptors. Out-of-phase electron spin echo signal was detected for both composites, which is the signature of the charge-transfer state (CT state) formed at the donor/acceptor interface upon exciton splitting. Nearly identical distribution of the distances between the electron and the hole constituting the CT state was obtained for these composites from the analysis of this signal. In both cases the average electron-hole distance was 3.5 nm. It implies that OPV efficiency increase with Y-T addition is not caused by the increased probability of CT state dissociation followed by free charge generation for PM6/Y6:Y-T composite.
Height-Related Polygenic Variants Are Associated with Metabolic Syndrome Risk and Interact with Energy Intake and a Rice-Main Diet to Influence Height in KoGES
Authors: Park Sunmin
Published: April 2023

Adult height is inversely related to metabolic syndrome (MetS) risk, but its genetic impacts have not been revealed. The present study aimed to examine the hypothesis that adult height-related genetic variants interact with lifestyle to influence adult height and are associated with MetS risk in adults aged >40 in Korea during 2010–2014. Participants were divided into short stature (SS; control) and tall stature (TS; case) by the 85th percentile of adult height. The genetic variants linked to adult height were screened from a genome-wide association study in a city hospital-based cohort (n = 58,701) and confirmed in Ansan/Ansung plus rural cohorts (n = 13,783) among the Korean Genome and Epidemiology Study. Genetic variants that interacted with each other were identified using the generalized multifactor dimensionality reduction (GMDR) analysis. The interaction between the polygenic risk score (PRS) of the selected genetic variants and lifestyles was examined. Adult height was inversely associated with MetS, cardiovascular diseases, and liver function. The PRS, including zinc finger and BTB domain containing 38 (ZBTB38)_rs6762722, polyadenylate-binding protein-interacting protein-2B (PAIP2B)_rs13034890, carboxypeptidase Z (CPZ)_rs3756173, and latent-transforming growth factor beta-binding protein-1 (LTBP1)_rs4630744, was positively associated with height by 1.29 times and inversely with MetS by 0.894 times after adjusting for covariates. In expression quantitative trait loci, the gene expression of growth/differentiation factor-5 (GDF5)_rs224331, non-SMC condensin I complex subunit G (NCAPG)_rs2074974, ligand-dependent nuclear receptor corepressor like (LCORL)_rs7700107, and insulin-like growth factor-1 receptor (IGF1R)_rs2871865 was inversely linked to their risk allele in the tibial nerve and brain. The gene expression of PAIP2B_rs13034890 and a disintegrin and metalloproteinase with thrombospondin motifs-like-3 (ADAMTSL3)_rs13034890 was positively related to it. The PRS was inversely associated with MetS, hyperglycemia, HbA1c, and white blood cell counts. The wild type of GDF5_rs224331 (Ala276) lowered binding energy with rugosin A, D, and E (one of the hydrolyzable tannins) but not the mutated one (276Ser) in the in-silico analysis. The PRS interacted with energy intake and rice-main diet; PRS impact was higher in the high energy intake and the low rice-main diet. In conclusion, the PRS for adult height interacted with energy intake and diet patterns to modulate height and was linked to height and MetS by modulating their expression in the tibial nerve and brain.
Potential Effect of Glutamine in the Improvement of Intestinal Stem Cell Proliferation and the Alleviation of Burn-Induced Intestinal Injury via Activating YAP: A Preliminary Study
Authors: Chen Xia , Zhang Panyang , Zhang Yajuan , Fan Shijun , Wei Yan , Yang Zhifan , Wang Fengchao , Peng Xi
Published: April 2023

Burn injury is a common form of traumatic injury that leads to high mortality worldwide. A severe burn injury usually induces gut barrier dysfunction, partially resulting from the impairment in the proliferation and self-renewal of intestinal stem cells (ISCs) post burns. As a main energy substance of small intestinal enterocytes, glutamine (Gln) is important for intestinal cell viability and growth, while its roles in ISCs-induced regeneration after burns are still unclear. To demonstrate the potential effects of Gln in improving ISCs proliferation and alleviating burn-induced intestinal injury, in this study, we verified that Gln significantly alleviated small intestine injury in burned mice model. It showed that Gln could significantly decrease the ferroptosis of crypt cells in the ileum, promote the proliferation of ISCs, and repair the crypt. These effects of Gln were also confirmed in the mouse small intestine organoids model. Further research found that Yes-associated protein (YAP) is suppressed after burn injury, and Gln could improve cell proliferation and accelerate the renewal of the damaged intestinal mucosal barrier after burns by activating YAP. YAP is closely associated with the changes in intestinal stem cell proliferation after burn injury and could be served as a potential target for severe burns.
Trends in the Prevalence of Hepatitis B Virus, Hepatitis C Virus, and HIV Infections in Iranian Patients with Hereditary Bleeding Disorders
Authors: Gharoonpour Azar , Maleki Saeideh , Sharifi Hamid , Osia Seyedehsara , Sharafi Heidar , Keshvari Maryam
Published: April 2023

Background: Patients with hereditary bleeding disorders (HBDs) have always been vulnerable to transfusion-transmitted infections (TTIs) such as hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) infections due to being regular recipients of blood and blood products. This study aimed to detect the trends in the prevalence of HBV, HCV, and HIV infections by birthyear in Iranian patients with HBDs to show the efficacy of national interventions implemented to administrate control and to prevent these infections, i.e., blood safety, newborn HBV vaccination, and safe replacement treatments. Methods: In this retrospective study, the trends in the prevalence of hepatitis B core antibody (HBcAb), HCV antibody (HCV-Ab), and HIV antibody (HIV-Ab) in Iranian patients with HBDs born before 2012 were assessed using patients’ clinical archives. The determinants of HBV, HCV, and HIV infections were investigated in bivariable and multivariable logistic regression analyses. Results: Out of 1475 patients with HBDs, most were male (87.7%) and diagnosed with hemophilia A (52.1%) and severe bleeding disorder (63.7%). The prevalence of HBcAb, HCV-Ab, and confirmed HIV-Ab was 22.9%, 59.8%, and 1.2%, respectively. The trends in HBcAb, HCV-Ab, and HIV-Ab were all decreasing by birthyear and reached a stable level of 0% for patients with birthyears in 1999, 2000, and 1984, respectively. In multivariable analysis, birthyear was significantly associated with HBcAb prevalence. In the multivariable analysis, type of HBD; birthyear; bleeding severity; histories of receiving packed cells, fresh frozen plasma, and cryoprecipitate before 1996; and history of receiving factor concentrate before 1997 were highly associated with the prevalence of HCV-Ab. Moreover, in the bivariable analysis, birthyear and type of HBD were associated with HIV-Ab prevalence. Conclusion: This study demonstrated the decreasing trends in HBV, HCV, and HIV seroprevalence in Iranian patients with HBDs following preventive interventions such as HBV vaccination, blood safety measures, and the provision of safe replacement treatments.
Electrospinning Nanofibers as a Dressing to Treat Diabetic Wounds
Authors: Jang Eun Jo , Patel Rajkumar , Patel Madhumita
Published: April 2023

Globally, diabetic mellitus (DM) is a common metabolic disease that effectively inhibits insulin production, destroys pancreatic β cells, and consequently, promotes hyperglycemia. This disease causes complications, including slowed wound healing, risk of infection in wound areas, and development of chronic wounds all of which are significant sources of mortality. With an increasing number of people diagnosed with DM, the current method of wound healing does not meet the needs of patients with diabetes. The lack of antibacterial ability and the inability to sustainably deliver necessary factors to wound areas limit its use. To overcome this, a new method of creating wound dressings for diabetic patients was developed using an electrospinning methodology. The nanofiber membrane mimics the extracellular matrix with its unique structure and functionality, owing to which it can store and deliver active substances that greatly aid in diabetic wound healing. In this review, we discuss several polymers used to create nanofiber membranes and their effectiveness in the treatment of diabetic wounds.
High Efficacy on the Death of Breast Cancer Cells Using SPMHT with Magnetite Cyclodextrins Nanobioconjugates
Authors: Caizer Costica , Caizer-Gaitan Isabela Simona , Watz Claudia Geanina , Dehelean Cristina Adriana , Bratu Tiberiu , Soica Codruța
Published: April 2023

In this study, we present the experimental results obtained in vitro on the human breast adenocarcinoma cell line (MCF-7) by applying superparamagnetic hyperthermia (SPMHT) using novel Fe3O4-PAA–(HP-γ-CDs) (PAA is polyacrylic acid and HP-γ-CDs is hydroxypropyl gamma-cyclodextrins) nanobioconjugates previously obtained by us. In the in vitro SPMHT experiments, we used concentrations of 1, 5 and 10 mg/mL of Fe3O4 ferrimagnetic nanoparticles from Fe3O4-PAA–(HP-γ-CDs) nanobioconjugates suspended in culture media containing 1 × 105 MCF-7 human breast adenocarcinoma cells. The harmonic alternating magnetic field used in the in vitro experiments that did not affect cell viability was found to be optimal in the range of 160–378 Gs and at a frequency of 312.2 kHz. The appropriate duration of the therapy was 30 min. After applying SPMHT with these nanobioconjugates under the above conditions, MCF-7 cancer cells died out in a very high percentage, of until 95.11%. Moreover, we studied the field up to which magnetic hyperthermia can be safely applied without cellular toxicity, and found a new upper biological limit H × f ~9.5 × 109 A/m⋅Hz (H is the amplitude and f is the frequency of the alternating magnetic field) to safely apply the magnetic field in vitro in the case of MCF-7 cells; the value was twice as high compared to the currently known value. This is a major advantage for magnetic hyperthermia in vitro and in vivo, because it allows one to achieve a therapy temperature of 43 °C safely in a much shorter time without affecting healthy cells. At the same time, using the new biological limit for a magnetic field, the concentration of magnetic nanoparticles in magnetic hyperthermia can be greatly reduced, obtaining the same hyperthermic effect, while at the same time, reducing cellular toxicity. This new limit of the magnetic field was tested by us in vitro with very good results, without the cell viability decreasing below ~90%.
Recent Options and Techniques to Assess Improved Bioavailability: In Vitro and Ex Vivo Methods
Authors: Józsa Liza , Nemes Dániel , Pető Ágota , Kósa Dóra , Révész Réka , Bácskay Ildikó , Haimhoffer Ádám , Vasvári Gábor
Published: April 2023

Bioavailability assessment in the development phase of a drug product is vital to reveal the disadvantageous properties of the substance and the possible technological interventions. However, in vivo pharmacokinetic studies provide strong evidence for drug approval applications. Human and animal studies must be designed on the basis of preliminary biorelevant experiments in vitro and ex vivo. In this article, the authors have reviewed the recent methods and techniques from the last decade that are in use for assessing the bioavailability of drug molecules and the effects of technological modifications and drug delivery systems. Four main administration routes were selected: oral, transdermal, ocular, and nasal or inhalation. Three levels of methodologies were screened for each category: in vitro techniques with artificial membranes; cell culture, including monocultures and co-cultures; and finally, experiments where tissue or organ samples were used. Reproducibility, predictability, and level of acceptance by the regulatory organizations are summarized for the readers.
3D Printed Pharmaceutical Systems for Personalized Treatment in Metabolic Syndrome
Authors: Alqahtani Abdulsalam , Ahmed Mohammed , Mohammed Abdul , Ahmad Javed
Published: April 2023

The current healthcare system is widely based on the concept of “one size fit for all”, which emphasizes treating a disease by prescribing the same drug to all patients with equivalent doses and dosing frequency. This medical treatment scenario has shown varied responses with either no or weak pharmacological effects and exaggerated adverse reactions preceded by more patient complications. The hitches to the concept of “one size fits all” have devoted the attention of many researchers to unlocking the concept of personalized medicine (PM). PM delivers customized therapy with the highest safety margin for an individual patient’s needs. PM has the potential to revolutionize the current healthcare system and pave the way to alter drug choices and doses according to a patient’s clinical responses, providing physicians with the best treatment outcomes. The 3D printing techniques is a solid-form fabrication method whereby successive layers of materials based on computer-aided designs were deposited to form 3D structures. The 3D printed formulation achieves PM goals by delivering the desired dose according to patient needs and drug release profile to achieve a patient’s personal therapeutic and nutritional needs. This pre-designed drug release profile attains optimum absorption and distribution, exhibiting maximum efficacy and safety profiles. This review aims to focus on the role of the 3D printing technique as a promising tool to design PM in metabolic syndrome (MS).
Leveling Up: Evaluation of IV v. PO Linezolid Utilization and Cost after an Antimicrobial Stewardship Program Revision of IV to PO Conversion Criteria within a Healthcare System
Authors: Jaggar Jessica , Cleveland Kerry O. , Twilla Jennifer D. , Patterson Shanise , Hobbs Athena L. V.
Published: April 2023

The CDC’s Core Elements of an Antimicrobial Stewardship Program (ASP) lists intravenous (IV) to oral (PO) conversion as an important pharmacy-based intervention. However, despite the existence of a pharmacist-driven IV to PO conversion protocol, conversion rates within our healthcare system remained low. We aimed to evaluate the impact of a revision to the current conversion protocol on conversion rates, using linezolid as a marker due to its high PO bioavailability and high IV cost. This retrospective, observational study was conducted within a healthcare system composed of five adult acute care facilities. The conversion eligibility criteria were evaluated and revised on 30 November 2021. The pre-intervention period started February 2021 and ended November 2021. The post-intervention period was December 2021 to March 2022. The primary objective of this study was to establish if there was a difference in PO linezolid utilization reported as days of therapy per 1000 days present (DOT/1000 DP) between the pre- and post-intervention periods. IV linezolid utilization and cost savings were investigated as secondary objectives. The average DOT/1000 DP for IV linezolid decreased from 52.1 to 35.4 in the pre- and post-intervention periods, respectively (p < 0.01). Inversely, the average DOT/1000 DP for PO linezolid increased from 38.9 in the pre-intervention to 58.8 for the post-intervention period, p < 0.01. This mirrored an increase in the average percentage of PO use from 42.9 to 62.4% for the pre- and post-intervention periods, respectively (p < 0.01). A system-wide cost savings analysis showed projected total annual cost savings of USD 85,096.09 for the system, with monthly post-intervention savings of USD 7091.34. The pre-intervention average monthly spend on IV linezolid at the academic flagship hospital was USD 17,008.10, which decreased to USD 11,623.57 post-intervention; a 32% reduction. PO linezolid spend pre-intervention was USD 664.97 and increased to USD 965.20 post-intervention. The average monthly spend on IV linezolid for the four non-academic hospitals was USD 946.36 pre-intervention, which decreased to USD 348.99 post-intervention; a 63.1% reduction (p < 0.01). Simultaneously, the average monthly spend for PO linezolid was USD 45.66 pre-intervention and increased to USD 71.19 post-intervention (p = 0.03) This study shows the significant impact that an ASP intervention had on IV to PO conversion rates and subsequent spend. By revising criteria for IV to PO conversion, tracking and reporting results, and educating pharmacists, this led to significantly more PO linezolid use and reduced the overall cost in a large healthcare system.
Evaluation of Miscanthus × giganteus Tolerance to Trace Element Stress: Field Experiment with Soils Possessing Gradient Cd, Pb, and Zn Concentrations
Authors: Bastia Giulia , Al Souki Karim Suhail , Pourrut Bertrand
Published: April 2023

Miscanthus × giganteus demonstrated good phytostabilization potentials by decreasing the trace elements (T.E.s) mobility and enhancing the degraded soil quality. Nevertheless, most of the published work was performed under controlled conditions in ex situ pot experiments and/or with soils being spiked. Hence, data about the plant’s tolerance to increased T.E. concentrations in real conditions is still scarce and requires further investigation. For this sake, a field experiment was established by cultivating miscanthus plants in three different agricultural plots representing gradient trace element (Cd, Pb and Zn) concentrations. Another uncontaminated plot was also introduced. Results showed that T.E. concentrations in the leaves were tolerable to the plant. In addition, no variations were detected between the miscanthus cultivated in the contaminated and uncontaminated soils at the level of antioxidant enzymatic activities (ascorbate peroxidase and superoxide dismutase), photosynthetic pigments (chlorophyll a and b and carotenoids), and secondary metabolites (phenolic compounds, flavonoids, anthocyanins, and tannins). These outcomes validate the high capacity of miscanthus to resist and tolerate contaminated conditions. Such results may contribute to further understanding of the miscanthus tolerance mechanisms.
“Green” PBX Formulations Based on High Explosives (RDX and HMX) and Water-Soluble pH-Sensitive Polymeric Binders
Authors: Rotariu Traian , Moldovan Andreea Elena , Toader Gabriela , Diacon Aurel , Rusen Edina , Ginghina Raluca Elena , Iorga Ovidiu , Botiș Horia Răzvan , Klapötke Thomas
Published: April 2023

The increasingly harsher and more complex international and European environmental legislation drives the current development of “greener” energetics materials and munitions. The aerospace and defense industries rely on extensive research in the formulation and scale-up production of polymer-bonded explosives (PBX). In this context, this paper aims to present a versatile method for obtaining “green” PBX formulations based on two high explosives (hexogen (RDX) and octogen (HMX)) and acrylic acid—ethyl acrylate copolymeric binders. This study developed an innovative “eco-friendly” technology for coating the RDX and HMX crystals, allowing straightforward and safer manufacture of PBX, avoiding the use of traditional organic solvents. At the same time, these polymeric binders are soluble in water at a slightly alkaline pH and insoluble at acidic or neutral pH, thus ensuring a safer manipulation of the energetic materials during their entire life cycle and a facile recovery of the explosive in its original shape and morphology in demilitarization. The PBX formulations were characterized via specific analytical tools to evaluate the influence of their composition on the safety and performance characteristics: scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), alkaline pH solubility tests, differential thermal analysis (DTA), impact sensitivity test (BAM Fall Hammer Test), friction sensitivity test (BAM Friction Test), electrostatic sensitivity test (ESD), vacuum stability test, small scale shock reactivity test (SSRT), detonation velocity test. The “green” PBX formulations obtained through a simple and innovative coating method, based on the polymeric binders’ adjustable water solubility, demonstrated remarkable energetic performances and a facile recovery of the explosive crystals by the dissolution of the polymeric binder at pH 11 and 30 °C.
Eudragit Films as Carriers of Lipoic Acid for Transcorneal Permeability
Authors: Bierbrauer Karina L. , Comini Laura R. , Leonhard Victoria , Escobar Manzanelli Micaela A. , Castelli Gabriela , Farfán Silvia , Alasino Roxana V. , Beltramo Dante M.
Published: April 2023

Diabetes mellitus (DM) is a highly prevalent disease affecting almost 10% of the world population; it is characterized by acute and chronic conditions. Diabetic patients have twenty-five times higher risk of going blind and developing cataracts early than the general population. Alpha-lipoic acid (LA) is a highly valuable natural antioxidant for the prevention and treatment of ophthalmic complications, such as diabetic keratopathy and retinopathy. However, its applicability is limited due to its low solubility in water; therefore, suitable systems are required for its formulation. In this work we developed an erodible insert based on Eudragit E100 (E PO) and Lipoic Acid (LA) for the delivery of this compound for the preventive treatment of ocular diseases especially in diabetic patients. Film evaluation was carried out by mechanical and thermal properties, mucoadhesivity, drug release, dynamic light scattering and corneal permeability as the concentration of LA increased. It was shown that upon LA release, it forms nanoparticles in combination with E PO that favor corneal permeation and LA retention in the cornea. These E PO-LA films also resulted non-irritable hence they are promising for their application in the treatment of ocular diseases.
Gas-Driven Endoscopic Robot for Visual Inspection of Corrosion Defects Inside Gas Pipelines
Authors: Fang Jin , Xiang Jun , Ma Li , Liu Hao , Wang Chenxiang , Liang Shan
Published: April 2023

The internal inspection of corrosion in large natural gas pipelines is a fundamental task for the prevention of possible failures. Photos and videos provide direct proof of internal corrosion defects. However, the implementation of this technique is limited by fast robot motion and poor lighting conditions, with high-quality images being key to its success. In this work, we developed a natural gas-driven pipeline endoscopic robot (GDPER) for the visual inspection of the inner wall surfaces of pipelines. GDPER consists of driving, odometer, and vision modules connected by universal joints. It is designed to work in a 154 mm gas-pressurized pipeline up to a maximum of 6 MPa, allowing it to smoothly pass through bends and cross-ring welds at a maximum speed of 3 m/s using gas pressure driving. Test results have shown that HD MP4 video files can be obtained, and the location of defects on the pipelines can be detected by intelligent video image post-processing. The gas-driven function enables the survey of very long pipelines without impacting the transport of the pipage.
Particle Deposition Pattern on an Automotive Diesel Filter Using an Eulerian Probability Density Function Method
Authors: Valiño Luis , Mustata Radu , Hierro Juan , Hernández Juan Luis , García María José , Blasco Carlos , Chen Yi-Tung , Chen Lung-Wen , Roy Prosun
Published: April 2023

A full 3D numerical simulation of the two-phase flow made up of (bio)diesel and particles, has been carried out to reproduce the deposition pattern of particles in a BOSCH automotive filter. From a probability density function (PDF), a simple Eulerian-Eulerian two-phase model is proposed for diesel and particles. The proposed formulation allows for a detailed description of the relationship between the velocity and size of the particles. A Brinkman-Darcy approximation has been considered for the flow through the filtering paper and is proved to be sufficient for the typical filter working conditions. The new tool is able to reproduce the deposition pattern shown by the used filters.
Gas Formation of Cobalt and Copper in the Application of Unconstrained Co-Cr-Al-Cu Metal Powders in Submerged Arc Welding: Gas Phase Thermodynamics and 3D Slag SEM Evidence
Authors: Coetsee Theresa , De Bruin Frederik
Published: April 2023

Aluminium metal is not typically added to the submerged arc welding (SAW) process because it is easily oxidised to form unwanted slag in the weld pool. The successful application of aluminium as a de-oxidiser is illustrated in this study by preventing oxidation of Cr and Co to their oxides, thereby preventing element loss to the slag. Unconstrained pure metals of Al, Cr, Co and Cu were applied to investigate the gas formation behaviour of these elements in the SAW arc cavity. Of interest is the effect of copper in the arc cavity in terms of its possible substitution for aluminium. The results confirmed that the Al-Cr-Co-Cu alloyed weld metal total oxygen content was lowered to 176 ppm O, in comparison to 499 ppm O in the weld metal formed from welding with the original flux, which excluded metal powder additions. This lower ppm O value of 176 ppm O confirms that the added aluminium powder effectively lowered the original flux-induced partial oxygen pressure in the arc cavity, and at the molten flux–weld pool interface. Carbon steel was alloyed to 5.3% Co, 5.5% Cr, 5.3% Cu and 4.5% Al at 78% Co yield, 82% Cr yield, 78% Cu yield and 66% Al yield. Thermochemical equilibrium calculations confirm the partial oxygen pressure-lowering effect of aluminium when considering the gas–slag–alloy equilibrium. BSE (backscattered electron) images of the three-dimensional (3D) post-weld slag sample show dome structures which contain features of vapour formation and re-condensation. SEM-EDX (scanning electron microscope-energy dispersive X-ray) maps show that the dome surface matrix phase consists of Al-Mg-Ca-Si-Na-K-Ti-Fe-Mn oxy-fluoride. The spherical 3D structures of 10–40 µm in diameter consist of Fe-Mn-Si fluorides with some Cr, Cu and Co contained in some of the spheres. Cr and Co were observed in distinctive porous structures of approximately 10 µm in size, consisting partly of Cr oxy-fluoride and partly of Co oxy-fluoride. Nano-sized oxy-fluoride strands and spheres in the dome structures confirm vaporisation and re-condensation of oxy-fluorides. Cu and Na formed a distinct condensation pattern on the surface of the Si-Cu-Na-Mn-Fe-Co oxy-fluoride sphere. The results confirm the importance of including gas phase reactions in the interpretation of SAW process metallurgy.
Hydroxypropyl-β-Cyclodextrin-Glycerol-Assisted Extraction of Phenolics from Satureja montana L.: Optimization, Anti-Elastase and Anti-Hyaluronidase Properties of the Extracts
Authors: Marijan Marijan , Jakupović Lejsa , Končić Marijana
Published: April 2023

A green method for hydroxypropyl-β-cyclodextrin-glycerol-assisted extraction (HCGAE) of bioactive phenolics from S. montana, Lamiaceae was optimized using Box-Behnken design and response surface methodology and compared conventional water/ethanol-based extraction. The procedure was aimed at obtaining extracts with the maximum content of total phenols (TP), flavonoids (TF), dihydroxycinnamic acids (TDCA), rosmarinic acid (RA), and luteolin 7-O-glucoside (LG). The impact of glycerol content (0–70%), 2-hydroxypropyl-β-cyclodextrin content (0–0.4 mmol), temperature (20–70 °C), herbal material weight (0.3–0.8 g), extraction duration (5–25 min), and ultrasound power (144–720 W) on the extraction efficiency was analyzed. Four extracts with maximum amounts of target phenols, OPT-TP (5.93 mg/mL), OPT-TDCA-RA (4.17 mg/mL and 1.16 mg/mL, respectively), OPT-TF (0.99 mg/mL), and OPT-LG (0.28 mg/mL) were prepared. Comparison of the content of TDCA, TF, RA, and LG with those obtained in water/ethanol-based extraction demonstrated the superiority of the HCGAE approach for the extraction of phenols from S. montana. The extracts displayed good anti-elastase and excellent anti-hyaluronidase activity. IC50 values of the anti-hyaluronidase activity (1.67 ± 0.06 μL extract/mL, 1.16 ± 0.08 μL extract/mL, 0.85 ± 0.03 μL extract/mL, and 0.79 ± 0.05 μL extract/mL for OPT-TP, OPT-TDCA-RA, OPT-TF, and OPT-LG, respectively) surpassed that of the applied positive control, tannic acid. The observed bioactivity of the optimized extracts makes them promising active ingredients for natural cosmetics. The results of this research indicate that HCGAE is an excellent alternative to conventional water/ethanol-based extraction of phenolics from Satureja montana L.-yielding extracts with potent anti-elastase and anti-hyaluronidase properties suitable for direct use in cosmetic products.
Shotgun Proteomics of Co-Cultured Leukemic and Bone Marrow Stromal Cells from Different Species as a Preliminary Approach to Detect Intercellular Protein Transfer
Authors: Nevárez-Ramírez Abraham Josué , Guzmán-Ortiz Ana Laura , Cortes-Reynosa Pedro , Perez-Salazar Eduardo , Jaimes-Ortega Gustavo Alberto , Valle-Rios Ricardo , Marín-Hernández Álvaro , Rodríguez-Zavala José S. , Ruiz-May Eliel , Castrejón-Flores José Luis , Quezada Héctor
Published: April 2023

Cellular interactions within the bone marrow microenvironment modulate the properties of subsets of leukemic cells leading to the development of drug-resistant phenotypes. The intercellular transfer of proteins and organelles contributes to this process but the set of transferred proteins and their effects in the receiving cells remain unclear. This study aimed to detect the intercellular protein transfer from mouse bone marrow stromal cells (OP9 cell line) to human T-lymphoblasts (CCRF-CEM cell line) using nanoLC-MS/MS-based shotgun proteomics in a 3D co-culture system. After 24 h of co-culture, 1513 and 67 proteins from human and mouse origin, respectively, were identified in CCRF-CEM cells. The presence of mouse proteins in the human cell line, detected by analyzing the differences in amino acid sequences of orthologous peptides, was interpreted as the result of intercellular transfer. The transferred proteins might have contributed to the observed resistance to vincristine, methotrexate, and hydrogen peroxide in the co-cultured leukemic cells. Our results suggest that shotgun proteomic analyses of co-cultured cells from different species could be a simple option to get a preliminary survey of the proteins exchanged among interacting cells.
One Secret for a High Citation Rate
Authors: Carotenuto Gianfranco , Nicolais Francesca
Published: April 2023

The relevance of the technical results included in a scientific paper is proved by the quantity of citations received by the article over the years [...]
Sunni Ḥadīth and Continuous Commentaries on the Eschatological Mahdī: A Literary Analysis
Authors: Bin Muhammad Yusoff Muhammad Fawwaz , Ismail Mohd Yusuf
Published: April 2023

Many contemporary studies approach Mahdism from a political-science orientation or historical perspective, as the evidence is marshalled from the influential Mahdist movement in Islamic history—Abbasids, Fatimids, Muwahhids, Sudanese Mahdists, and so on. As such, it can be seen that there has been a lack of discourse as regards abstraction, particularly concerning the literary structure of Mahdī ḥadīth. This paper explores a panoramic view of ḥadīth commentaries in order to understand their commentarial production on apocalyptic questions, specifically focusing on the subject of Mahdī within this trend of Sunni ḥadīth scholarship. Ḥadīth commentaries are meant to bridge the gap in space and time between Prophetic words or teachings and the actual world of the reader. Hence, this study provides a brief survey of the documentation of Mahdī ḥadīth, starting with the classical Sunnite ḥadīth compendia of the second century of Hijrah. The material has been drawn from ḥadīth compendia, topical ḥadīth works, sīrah literature, classical-to-modern ḥadīth commentaries, and other theological writings and has been balanced when feasible with details (or lack thereof) contained in the Quran. Advocators have always adopted and adjusted their hermeneutics in order to answer challenges posed by deniers of Mahdī ḥadīth. Regardless of how exactly these strategies, attitudes, and uses arose, it is safe to assume that these scholars undertook their work out of professional vocation in addition to religious devotion. Eventually, ḥadīth commentaries found their place in the theological discourse according to orientations and operations of eschatology, which to a certain extent reflect classical, medieval, or contemporary attitudes toward the meaning and relevance of Mahdī ḥadīth.
On Surface Waves Generated by Extra-Tropical Cyclones—Part I: Multi-Satellite Measurements
Authors: Cheshm Siyahi Vahid , Kudryavtsev Vladimir , Yurovskaya Maria , Collard Fabrice , Chapron Bertrand
Published: April 2023

Surface waves generated by Extra-Tropical Cyclones (ETCs) can significantly affect shipping, fishing, offshore oil and gas production, and other marine activities. This paper presents the results of a satellite data-based investigation of wind waves generated by two North Atlantic ETCs. These ETCs were fast-moving systems, inhibiting resonance (synchronism) between the group velocity of the generated waves and the ETC translation velocity. In these cases, wave generation begins when the front boundary of the storm appears at a given ocean location point. Since developing waves are slow, they move backward relative to the storm, grow in time, and then leave the ETC stormy area through the rear sector. Multi-satellite observations confirm such a paradigm, revealing that the storm regions are filled with young developing wind waves, the most developed in the rear-right sector. As observed, the energy of these waves grew in time during the ETC life span. It is demonstrated that the extended-fetch concept (inherent for Tropical Cyclones) does not apply to ETC. Instead, by analogy, the concept of extended-duration wave growth is more relevant. Satellite observations confirmed the validity of duration-laws for waves generated by ETCs, and demonstrated that extended-fetch solutioncan be valid at time scales exceeding the lifespan of considered ETCs.
Voltammetric Detection of Vanillylmandelic Acid and Homovanillic Acid Using Urea-Derivative-Modified Graphite Electrode
Authors: Shishkanova Tatiana V. , Králík František , Synytsya Alla
Published: April 2023

Vanillylmandelic acid (VMA) and homovanillic acid (HVA) are diagnostic markers of neuroblastoma. The purpose of this study was to understand the reason for the discrimination of structural analogues (VMA and HVA) onto a graphite electrode coated with an electrochemically oxidized urea derivative. Density functional theory calculations (DFT), FTIR spectroscopic measurements, and electrochemical impedance spectroscopic measurements were used in this work. Density functional theory calculations (DFT) were used to identify the most suitable binding sites of the urea derivative and to describe possible differences in its interaction with the studied analytes. The FTIR measurement indicated the enhancement and disappearance of NH vibrations on graphite and platinum surfaces, respectively, that could be connected to a different orientation and thus provide accessibility of the urea moiety for the discrimination of carboxylates. Additionally, the higher the basicity of the anion, the stronger the hydrogen-bonding interaction with –NH-groups of the urea moiety: VMA (pKb = 10.6, KAds = (5.18 ± 1.95) × 105) and HVA (pKb = 9.6, KAds = (4.78 ± 1.58) × 104). The differential pulse voltammetric method was applied to detect VMA and HVA as individual species and interferents. As individual analytes, both HVA and VMA can be detected at a concentration of 1.99 × 10−5 M (RSD ≤ 0.28, recovery 110–115%).
SpectralMAE: Spectral Masked Autoencoder for Hyperspectral Remote Sensing Image Reconstruction
Authors: Zhu Lingxuan , Wu Jiaji , Biao Wang , Liao Yi , Gu Dandan
Published: April 2023

Accurate hyperspectral remote sensing information is essential for feature identification and detection. Nevertheless, the hyperspectral imaging mechanism poses challenges in balancing the trade-off between spatial and spectral resolution. Hardware improvements are cost-intensive and depend on strict environmental conditions and extra equipment. Recent spectral imaging methods have attempted to directly reconstruct hyperspectral information from widely available multispectral images. However, fixed mapping approaches used in previous spectral reconstruction models limit their reconstruction quality and generalizability, especially dealing with missing or contaminated bands. Moreover, data-hungry issues plague increasingly complex data-driven spectral reconstruction methods. This paper proposes SpectralMAE, a novel spectral reconstruction model that can take arbitrary combinations of bands as input and improve the utilization of data sources. In contrast to previous spectral reconstruction techniques, SpectralMAE explores the application of a self-supervised learning paradigm and proposes a masked autoencoder architecture for spectral dimensions. To further enhance the performance for specific sensor inputs, we propose a training strategy by combining random masking pre-training and fixed masking fine-tuning. Empirical evaluations on five remote sensing datasets demonstrate that SpectralMAE outperforms state-of-the-art methods in both qualitative and quantitative metrics.
Kinetics of Chemisorption on the Surface of Nanodispersed SnO2–PdOx and Selective Determination of CO and H2 in Air
Authors: Vasiliev Alexey , Shaposhnik Alexey , Moskalev Pavel , Kul Oleg
Published: April 2023

In this work, the kinetics and mechanisms of the interaction of carbon monoxide and hydrogen with the surface of a nanosized SnO2–PdOx metal oxide material in air is studied. Non-stationary temperature regimes make it possible to better identify the individual characteristics of target gases and increase the selectivity of the analysis. Recently, chemometric methods (PCA, PLS, ANN, etc.) are often used to interpret multidimensional data obtained in non-stationary temperature regimes, but the analytical solution of kinetic equations can be no less effective. In this regard, we studied the kinetics of the interaction of carbon monoxide and hydrogen with atmospheric oxygen on the surface of SnO2–PdOx using semiconductor metal oxide sensors under conditions as close as possible to classical gas analysis. An analysis of the influence of catalytic surface temperature on the mechanisms of chemisorption processes allowed us to correctly interpret and mathematically describe the electrophysical characteristics of the sensor in the selective determination of carbon monoxide and hydrogen under nonstationary temperature conditions. The reaction mechanism is applied as well to the analysis of the operation scheme of the CO sensor TGS 2442 of Figaro Inc.
Kernel Estimation Using Total Variation Guided GAN for Image Super-Resolution
Authors: Park Jongeun , Kim Hansol , Kang Moon Gi
Published: April 2023

Various super-resolution (SR) kernels in the degradation model deteriorate the performance of the SR algorithms, showing unpleasant artifacts in the output images. Hence, SR kernel estimation has been studied to improve the SR performance in several ways for more than a decade. In particular, a conventional research named KernelGAN has recently been proposed. To estimate the SR kernel from a single image, KernelGAN introduces generative adversarial networks(GANs) that utilize the recurrence of similar structures across scales. Subsequently, an enhanced version of KernelGAN, named E-KernelGAN, was proposed to consider image sharpness and edge thickness. Although it is stable compared to the earlier method, it still encounters challenges in estimating sizable and anisotropic kernels because the structural information of an input image is not sufficiently considered. In this paper, we propose a kernel estimation algorithm called Total Variation Guided KernelGAN (TVG-KernelGAN), which efficiently enables networks to focus on the structural information of an input image. The experimental results show that the proposed algorithm accurately and stably estimates kernels, particularly sizable and anisotropic kernels, both qualitatively and quantitatively. In addition, we compared the results of the non-blind SR methods, using SR kernel estimation techniques. The results indicate that the performance of the SR algorithms was improved using our proposed method.