bluuebunny/crossref_metadata_2025 huggingface dataset:
Peran Minat Beli Sebagai Variabel Intervening Pada Pengaruh Persepsi Harga, Kualitas Produk, dan Promosi Terhadap Keputusan Pembelian
Authors: Zararosa Gracia Angel , Khasanah Imroatul
Published: September 2024

The food and beverage industry is growing rapidly. The attractiveness of this industry in Indonesia is very strong, this makes business opportunities in the food and beverage sector have mushroomed and are promising. Supported by the increasing number of franchise business offers that are quite easy to do and new types of culinary such as contemporary drinks, coffee shops, and so on. Old culinary types such as processed chicken, pizza, and other fast food also innovate unique flavors and appearances to attract the millennial generation's interest. One of them is Pizza Hut. According to financial report data, sales have decreased since 2020 and 2021, in addition, data on the Top Brand Index has decreased for 3 consecutive years in 2017, 2018, and 2019. In addition, there are inconsistencies in the results of research on the relationship of Product Quality to Purchasing Decisions. Because of these problems, this research was carried out. This study aims to analyze and prove the influence of Price Perception, Product Quality, and Promotion on Purchasing Decisions through Buying Interest as an Intervening Variable (Study on Pizza Hut Customers in Semarang City.)
Analisis Pengaruh Rasio Hutang dan Laba Terhadap Nilai Perusahaan Pada Perusahaan Manufaktur Yang Terdaftar di Bursa Efek Indonesia Tahun 2020
Authors: Mudin Runi , Hadady E. Hartaty , Ali Taslim Fadli
Published: September 2024

Penelitian ini bertujuan untuk mengetahui dan menganalisis pengaruh rasio hutang dan laba terhadap nilai perusahaan pada perusahaan manufaktur yang terdaftar di bursa efek indonesia tahun 2020. Data yang digunakan dalam penelitian ini adalah data sekunder dan sampel berupa laporan-laporan keuangan dari 47 perusahan manufaktur yang terdaftar di bursa efek indonesia tahun 2020 menggunakan purposive sampling dan data analisis menggunakan uji statistik destriptif, uji asumsi klasik, uji analisis regresi linier berganda dan uji hipotesis. Data dianalisis dengan menggunakan software SPSS versi 25.Hasil penelitian ini menunjukan bahwa variabel rasio hutang berpengaruh negatif terhadap nilai perusahaan, sedangkan variabel manajemen laba berpengaruh posistif dan signifikan terhadap nilai perusahaan.
Effect of PPAR-γ Agonist Rosiglitazone on Bone Mineral Density and Serum Adipokines in C57BL/6 Male Mice
Authors: Broulík Petr Dan , Šefc L. , Haluzík M.
Published: September 2024

Thiazolinediones (TZD) are widely used to treat type 2 diabetes, but their mechanism of action still remains only partially understood. Although the in vitro effects of TZD on osteoblastogenesis are well recognized, the in vivo consequences of these compounds on bone turnover are less understood and rather controversial. We demonstrate that a 9-week oral treatment with rosiglitazone in C57BL/6 male mice resulted in significant bone loss that was not dose dependent. The bones of the rosiglitazone-treated mice were characterized by reduction of bone density, and ash, calcium and phosphorus content. Rosiglitazone-treated mice had significantly thinner cortical widths. In contrast to serum TrACP expressed by action of osteoclasts, serum B-ALP activity, which serves as a marker of osteoblastic activity, was significantly lower in the rosiglitazone-fed animals. We did not find any differences in circulating levels of adipokines that could eventually explain rosiglitazone action. As the decrease in osteoblastic activity was demonstrated after rosiglitazone treatment, we anticipated changes in the haematopoietic stem cell pool. These cells seed in endosteal niches which comprise osteoblasts in order to maintain their stem cell function. In our study we did not see any significant influence of rosiglitazone administration on stem cells or any impairment in the lineage restrictions of rosiglitazone-treated stem cells. Our data demonstrate that rosiglitazone administration causes a loss of bone mass in cortical bone, possibly through a decrease in bone formation expressed by decreased B-ALP in male C57BL/6 mice. The levels of adipokines do not play any role.
RhoA Distribution in Renal Caveolar Fractions in Experimental Type 1 Diabetes
Authors: Demová Hana , Černá M.
Published: September 2024

Caveolae act as signalling platforms serving as concentrating points for numerous signalling molecules, as well as regulating flux through many distinct signalling cascades. RhoA proteins have been identified as potential actors in the pathophysiology of the cardiovascular system. We used sucrose gradient fractionation and immunoblotting to determine caveolin-1 and RhoA presence in the kidney cortex of streptozotocin-induced T1 diabetes rats (4-week duration), and of diabetic rats treated with angiotensin receptor blocker losartan (4 weeks, 20 mg/kg/day) to retard renal hypertension. Positive RhoA/caveolin-1 co-immunoprecipitation result was detected in the caveolar fraction that corresponded to the light-scattering band obtained from diabetic rats, compared to negative co-immunoprecipitation result in the caveolar fraction obtained from control rats. The detection of RhoA protein in the caveolar fractions and the prospective RhoA/caveolin-1 association can be used to examine the role of these signalling reactions in the pathophysiology of microvascular complications in type 1 diabetes.
The Influence of Vascular Endothelial Growth Factor (VEGF) Polymorphism on the Progression of Chronic Glomerulonephritides
Authors: Šafránková Hana , Merta M. , Reiterová J. , Štekrová J. , Maixnerová D. , Ryšavá R. , Skibová J. , Tesař V.
Published: September 2024

Vascular endothelial growth factor is an important mediator in maintaining normal kidney functions. In addition, several lines of evidence show that up-regulation of this mediator in glomeruli may be associated with or may directly cause renal dysfunction. We tried to assess the influence of the -2578 C/A and -1154 G/A polymorphisms in the regulatory region of the vascular endothelial growth factor gene upon progression of three primary chronic glomerulonephritides (minimal change disease/focal and segmental glomerulosclerosis, membranous nephropathy, immunoglobulin A nephropathy). We studied a cohort of 213 patients compared to 311 unrelated healthy controls. Analysis of the C/A polymorphism of vascular endothelial growth factor revealed an increased prevalence of CC genotype in the minimal change disease/focal and segmental glomerulosclerosis group in comparison with the other groups. A balanced distribution of G and A alleles among the respective types of chronic glomerulonephritides was shown in the analysis of -1154 G/A polymorphism. Finally, we have not proved any significant influence of the polymorphisms at positions -2578 C/A and -1154 G/A of the vascular endothelial growth factor gene promoter on the progression of chronic glomerulonephritides even though our study suggests a negative effect of CC genotype of -2578 C/A polymorphism on the clinical course of minimal change disease/focal segmental glomerulosclerosis.
Comparison of P19-Derived Neuroprogenitor and Naive Cell Survival after Intracerebellar Application into B6CBA Mice
Authors: Houdek Z. , Cendelín J. , Kulda V. , Babuška V. , Vožeh F. , Hatina J. , Králíčková Milena , Zech N. H. , Veselá I. , Pacherník J. , Uher P.
Published: September 2024

Mouse embryonic carcinoma cells (P19 line) were studied for both their survival and developmental potential in the intact cerebellum of B6CBA mice. The P19 cells were cultured and labelled with green fluorescent protein using transfection. Cells were used for transplantation either in the undifferentiated stage or after 3 days of neurodifferentiation induced by retinoic acid. The intracerebellar application was performed in 43 mice: group A (N = 21) received neuroprogenitors and group B (N = 22) received undifferentiated cells. The morphology of transplanted cells within the context of the surrounding cerebellar tissue was evaluated after 3 weeks. Naive P19 cells engrafted and survived in the cerebellum of 7 of the 22 adult mice (survival rate 31.8 %). Neuroprogenitors survived in 13 of the 21 mice (survival rate was 61.9 %). Since the cut-off is P < 0.05, the difference is not statistically significant (P = 0.069). An expansive appearance of the graft was significantly more frequent (P = 0.0047) in naive P19 cells than in neuroprogenitors. In mice in which the grafts did not survive, no marks of grafted cells or only fluorescing detritus were found. In conclusion, this is the first study to track the fate and morphology of embryonic carcinoma cells transplanted into the cerebellum, confirming that neuroprogenitors derived from embryonic carcinoma cells can settle in the host tissue and differentiate according to the surrounding conditions. With further validation, the embryonic carcinoma cells could become a valuable model with which to study the impact of cell therapy on neurodegenerative diseases.
INSIG2 G-102A Promoter Variant Exhibits Context-Dependent Effect on HDL-Cholesterol Levels but Not on BMI in Caucasians
Authors: Hubáček Jaroslav A. , Suchánek P. , Lánská V. , Piťha J. , Adámková V.
Published: September 2024

The INSIG2 (INSIG2 is primarily involved in the regulation of fatty acid and cholesterol synthesis) gene is suggested to be obesity related. An INSIG2 promoter variant, G-102A, has been detected and was demonstrated to be of potential functional significance. In two cohorts of middle-aged men, the association between this variant and BMI was suggested. We sought to replicate the association between the INSIG2 G-102A variant and BMI in three large Slavonic Caucasian populations. Further, we analysed the possible effect of this variant on BMI changes in a short-time intervention study. One thousand ninety-nine males and 1368 females (population-based Czech MONICA three-year cohort), 908 females from the 3PMFs study, together with 94 overweight (BMI > 27 kg/m2) females who underwent nine weeks of dietary/exercise intervention were genotyped for the INSIG2 G-102A variant using PCR-RFLP analysis. We could not detect any association between the INSIG2 G-102A variant and BMI or WHR with or without adjusting for age and gender in any population. Neither the BMI change nor anthropometric and lipid parameter changes were affected by the INSIG2 G-102A gene variant in intervened overweight females. However, MONICA females (but not males) carrying the common GG genotype had higher plasma levels of HDL cholesterol (GG homozygotes 1.51 ± 0.36 mmol/l vs. A allele carriers 1.45 ± 0.33; P < 0.05) in both surveys. Our results indicated that the G-102A INSIG2 polymorphism has no consistent effect on BMI in general populations, but could influence HDL cholesterol in females.
Effect of Positional Changes on Cerebral Perfusion in Parkinson’s Disease Patients With Orthostatic Hypotension
Authors: Joo Jae Young , Yoo Dallah , Kim Jae-Myoung , Shin Chaewon , Ahn Tae-Beom
Published: September 2024

Objective Orthostatic hypotension (OH) is one of the most common autonomic dysfunctions in Parkinson’s disease (PD) patients. However, many patients with OH are asymptomatic. Conversely, orthostatic dizziness (OD) is not always associated with OH. We investigated the effects of positional changes on cerebral perfusion in patients with PD and OH.Methods We enrolled 42 patients, comprising 31 PD patients and 11 healthy controls. All the subjects underwent the following clinical assessments: the OH questionnaire, head-up tilt test (HUTT) with transcranial Doppler (TCD), near-infrared spectroscopy, measurement of the change in oxygenated hemoglobin (ΔHboxy) during the squat-to-stand test (SST), measurement of the time derivative of total hemoglobin (DHbtot), and time taken to reach the peak (peak time [PT]) of DHbtot after restanding.Results The mean flow velocity change (ΔMFV) in the TCD during the HUTT failed to differentiate between the PD-OH(+) and PD-OH(-) groups. The change in oxygenated hemoglobin ΔHboxy was greater in the PD-OH(+) group, which persisted for 9 min until the end of the HUTT only in the left hemisphere. During SST, PT was significantly delayed in the left hemisphere in PD-OH(+) patients.Conclusion Although TCD demonstrated no significant difference in ΔMFV, the parameters measured by near-infrared spectroscopy, such as ΔHboxy during HUTT and PT during the SST, significantly increased ΔHboxy or delayed PT in the left hemisphere of PD-OH(+). Positional changes have a detrimental effect on cerebral hemodynamics in patients with PD and OH, especially in the left hemisphere.
The Intersection of Artificial Intelligence and Precision Endocrinology
Authors: Vlachakis Dimitrios , Dragoumani Konstantina , Papakonstantinou Eleni , Chrousos George
Published: September 2024

Bioinformatics and artificial intelligence (AI) have emerged as transformative tools in modern medicine, revolutionizing the landscape of medical diagnosis and treatment. Herein, we provide an overview of the synergistic relationship between bioinformatics and AI, elucidating their pivotal roles in deciphering complex biological data and advancing precision medicine and in particular endocrinology. We explore various applications of bioinformatics and AI in medical research, including genomic analysis, drug discovery, disease diagnosis, and personalized treatment strategies. Additionally, we discuss challenges and future directions in leveraging these technologies to enhance healthcare outcomes.
A fractional profile decomposition and its application to Kirchhoff-type fractional problems with prescribed mass
Authors: Tian Junshan , Zhang Binlin
Published: September 2024

In this article, we study the following fractional Kirchhoff-type problems with critical and sublinear nonlinearities:

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\left\{\begin{array}{l}\left(a+b\mathop{\iint }\limits_{{{\mathbb{R}}}^{N}\times {{\mathbb{R}}}^{N}}\frac{{| u\left(x)-u(y)| }^{2}}{{| x-y| }^{N+2s}}{\rm{d}}x{\rm{d}}y\right){\left(-\Delta )}^{s}u=\lambda {u}^{q-1}+{u}^{{2}_{s}^{* }-1},\hspace{1em}u\gt 0,\hspace{1em}\hspace{0.1em}\text{in}\hspace{0.1em}\hspace{0.33em}\Omega ,\\ u=0\left,\hspace{1em}\hspace{0.1em}\text{in}\hspace{0.1em}\hspace{0.33em}{{\mathbb{R}}}^{N}\backslash \Omega \right,\\ \mathop{\displaystyle \int }\limits_{{{\mathbb{R}}}^{N}}{u}^{2}{\rm{d}}x={c}^{2},\end{array}\right.

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. First, we prove that the bounded Palais-Smale sequence has a profile decomposition in the fractional Laplacian setting. Then, by utilizing decomposition techniques and variational methods, we acquire that there are two positive normalized solutions for the aforementioned problems.
The AI Revolution: A New Paradigm of Economic Order
Authors: Vöpel Henning
Published: September 2024

Artificial intelligence (AI) constitutes a new technological revolution that has far-reaching, somehow paradigmatic implications for the economy and as well as for the society – for good and for evil. Given the specific properties of artificial intelligence this article analyses the economic consequences of AI on productivity and growth, the distribution of income as well as on firms, markets, and competition. It argues that artificial intelligence is creating a new economic order that requires new approaches to economic policy and regulation. Issues of how to maintain competition, protect consumer rights, promote AI literacy and preserve ethical standards are at the center of a holistic AI governance.
A gradient typology of gerund clauses: revisiting the internal and external syntax of Portuguese gerund clauses
Authors: Lobo Maria
Published: September 2024

Focusing mostly on European Portuguese, this paper proposes that the internal syntax of Portuguese gerund clauses and the gradience in their degree of defectiveness may be explained by an interplay between their external syntax (locus of merge), agreement relations between embedded Tense and matrix Tense and the presence/absence of an intervening head. We first revisit the distinction between peripheral adverbial gerund clauses and central adverbial gerund clauses and show that their internal syntax correlates with their external syntax: central adverbial gerund clauses are merged in lower positions and appear to be more defective. We derive their defectiveness from the agree relation established between embedded T and matrix T. We then consider predicative gerund clauses and show that they are even more defective and restricted in their aspectual value, lacking a T head. Finally, we consider predicative gerund clauses introduced by como ‘as’ and show that, although they are merged in a low position, they are less defective than central adverbial gerund clauses. We attribute this mismatch between the internal and external syntax of this specific type of gerund clause to the presence of the Predicate head como, which intervenes between matrix T and embedded T and blocks the agreement relation.
The Role of Discrete Event Simulation for Assembly Planning
Authors: Gutmann Daniel , Preising Heimo , Rüdele Kai , Wolf Matthias
Published: September 2024

Montagelinien sind häufig sehr komplex und ihre Ausgestaltung hat direkten Einfluss auf Ausbringung und Margen. Die diskrete Eventsimulation (DES) gilt als ein leistungsstarkes Werkzeug zur Planung, Bewertung und Optimierung von Montageprozessen. Dieser Beitrag untersucht einen Ansatz für die Verwendung von DES für die Planung einer Montagelinien auf der Grundlage einer morphologischen Analyse. Im Fallbeispiel steht nicht die Qualität des Simulationsmodells im Vordergrund, sondern die Frage, wann dessen Einsatz sinnvoll ist.
Resilienzmanagement in der Lebensmittelindustrie
Authors: Mauermann Marc , Fischer Kai , Finger Jörg , Eisenrauch Vincent , Elles Anselm , Vogelbacher Georg , Stolz Alexander , Mehnert Kathleen
Published: September 2024

In an online survey, 154 decision-makers from the food industry were asked about resilience management, coping with disruptions, resilience characteristics, resilience dimensions and investment needs in their companies. This article analyses the survey, presents methods for assessing resilience and identifies potential for improvement. 84% of those surveyed responded that their companies had not yet implemented a resilience management system. Of the resilience dimensions, the impact of technology on ensuring the safety, quality and quantity of their products was rated highest, followed by finance. All respondents plan to invest in technology and digitalisation to increase resilience.
Strategisch planen, erfolgreich handeln
Authors: Fischer Tobias
Published: September 2024

This article highlights the important role that strategy development plays in general and especially for industrial companies. First, the history of strategy development is shown and the challenges that industrial companies face are explained. It discusses how strategy development is structured and implemented in a professional way. Finally, the article summarizes the most important steps in the form of a structured graphic and outlines the importance of strategy development for industrial companies.
Perfil de emprendimiento del estudiantado de dos universidades peruanas: Un estudio comparativo
Authors: Pezo-Arteaga Erik , Paredes-Limo Eduardo Fabrizzio
Published: September 2024

Introduction: The insertion into the labor market of university students is one of the most important motivations for pursuing higher education. At present, entrepreneurship is presented as an option that is becoming increasingly relevant. Objective. Identify and differentiate the way in which the entrepreneurship profile differs based on the population group to which the student belongs, influenced by sociodemographic factors. Methodology. Non-experimental, comparative-transversal, with a sample of 250 students from public and private universities, to whom a questionnaire of questions was administered to the students using the survey technique. To cross-reference the information and note the differences, we conducted a descriptive analysis using cross tables. To verify the hypotheses, the Mann-Whitney U and Kruskal-Wallis tests were used. Findings. It was identified that the only factor with significant value is the student’s work activity (0.027), while the other sociodemographic aspects presented a p-value > 0.05. Conclusion. There are no significant differences in the entrepreneurship profile in eight of the nine aspects evaluated. Implications. The entrepreneurship profile appears to be conditioned by the student’s current work activity.
A nanomedicina lehetőségei és korlátai a stroke-on átesett betegek gyógykezelésében
Authors: Bari Ferenc , Péter Viktória , Menyhárt Ákos , Farkas Eszter
Published: September 2024

A nanomedicina már jelenleg is segíti ugyan a stroke-betegek ellátását, de a
jövőben számos új lehetőséget kínál azáltal, hogy célzott terápiát, gyorsabb és
pontosabb diagnózist, valamint hatékonyabb gyógyszeres kezelést tesz lehetővé. A
nanotechnológiai megoldásokkal megtervezett molekulákat el lehet juttatni a
sérült agyterületre. Ott hatékonyan lehet emelni az adott hatóanyag
koncentrációját úgy, hogy mérséklődjenek a nemkívánatos mellékhatások. Ezzel
hatékonyabbá válhat a vérrögök feloldása, javulhat a reperfúzió hatásfoka, és
hatékonyabb cito- és neuroprotektív stratégiákat lehet alkalmazni. A vér–agy gát
sajátságos tulajdonságainak ismeretében számos, eddig a gyógyszerelés
szempontjából kihasználatlan transzportmechanizmus segítheti a gyógyszerelést. A
nanoszenzorokkal és a nanobázisú képalkotó eljárásokkal jelentősen javítható a
stroke okozta elváltozások korai felismerése, a sérülés mértékének pontos
meghatározása. A nanotechnológiai megoldások jelentős mértékben fokozhatják a
korábban állatmodellekben hatékonynak talált neuroprotektív szerek transzlációs
értékét. Így remény nyílik az agyszövet és a mikrokeringés regenerációjára is.
Továbbá a nanomedicina igen széles eszköztára lehetővé teszi a személyre szabott
terápiák fejlesztését. Orv Hetil. 2024; 165(36): 1403–1410.
Új módszer a májregeneráció fokozására: a máj kettős vénás sorvasztása
Authors: Kokas Bálint , Krizsány Gyula , Pekli Damján , Meltzer Anna , Bárdos Dávid , Rózsa Balázs , Bibok András , Korda Dávid , Somogyi Dóra , Doros Attila , Budai András , Halász Judit , Werling Klára , Hagymási Krisztina , Mühl Dorottya , Tegze Bálint , Nádasdy-Horváth Domonkos , Györke Tamás , Szijártó Attila , Hahn Oszkár
Published: September 2024

A májdaganatok reszekálhatóságának feltétele a műtét után megmaradó, megfelelő
májműködést biztosítani képes elégséges májszövetmennyiség. Ennek mérete a műtét
előtt különböző eljárásokkal növelhető meg. A vena (v.) portae occlusiós
technikákkal lassabb és csekélyebb növekedés érhető el, kis rizikójú intervenció
során. Amennyiben a hypertrophia nem elegendő, illetve ha felmerül a gyors
tumorpogresszió lehetősége, úgy alkalmazható a v. portae egyoldali elzárása és a
májállomány kettéválasztása, ami rövid idő alatt a legjelentősebb indukált
hypertrophiát biztosítja. A kombinált műtét morbiditása azonban viszonylag
jelentős. A fenti technikák előnyeit hivatott ötvözni a máj kettős vénás
elsorvasztása, melynek során az azonos oldali v. portae és v. hepatica
occlusiója történik. Ezzel gyors, az utóbbi módszert megközelítő mértékű
ellenoldali lebeny-hypertrophia érhető el biztonságosan. Esetünkön keresztül ezt
a májhipertrofizáló technikát mutatjuk be. A 75 éves nőbeteg bizonytalan hasi
panaszai miatt indult kivizsgálása során a máj jobb lebenyében, a középső
szektort is érintő, nagy méretű intrahepaticus cholangiocellularis tumor
igazolódott. Tekintettel a lokalizációra, a tumor csak jobb oldali
trisegmentectomiával volt eltávolítható. Májvolumetriát végeztünk, mely alapján
a megmaradó máj volumene (S1-2-3) 35% alattinak bizonyult. Kettős vénás
depriváció mellett döntöttünk. A jobb v. portae és v. hepatica dextra
occlusióját követő 7. napon jelentős hypertrophiát (41%) igazoltunk. A tervezett
műtétet sikeresen elvégeztük. A posztoperatív szakban enyhe ascites csorgását
konzervatívan kezeltük, egyéb szövődmény nem jelentkezett, a 8. posztoperatív
napon emittáltuk a beteget. Amennyiben a tervezett májreszekció kapcsán a
megmaradó máj várható térfogata nem elégséges, májregenerációs technikák
alkalmazására van szükség. Az elérhető technikák közül a legújabb, alacsony
szövődményrizikóval kecsegető megoldás a kettős vénás depriváció, mely során az
azonos oldali v. portae és v. hepatica elzárására kerül sor. A fenti eset
bizonyítja, hogy a módszertől gyors és hatékony májregeneráció várható minimális
megterheléssel, ami lehetővé teszi a biztonságos kiterjesztett májreszekciók
elvégzését. Orv Hetil. 2024; 165(36): 1433–1439.
Risk factors for adenomyosis in women of reproductive age
Authors:   Bogomolets National Medical University, Kyiv, Ukraine, Beniuk V.О. , Kurochka V.V. ,   Bogomolets National Medical University, Kyiv, Ukraine, Susak K.I. ,   Bogomolets National Medical University, Kyiv, Ukraine,
Published: September 2024

The problem of adenomyosis is of particular relevance to patients of reproductive age since these diseases are accompanied by significant violations of the menstrual and generative functions. Aim - determine the risk factors for the development of adenomyosis in women of reproductive age in order to improve a complex pathogenetically based approach in the selection of treatment. Materials and methods. Analysis of anamnestic data and examination of 90 women of reproductive age with adenomyosis, which made up the main group, was carried out. The control group - 30 gynecologically healthy non-pregnant women of reproductive age. Results. The article provides data on the results of clinical-statistical analysis among reproductive-age women with the adenomyosis. The risk factors of development of adenomyosis in investigated group are determined. Those are: complicated heredity, high frequency of the clinical abortions, spontaneous miscarriages, pathological deliveries in the past. The low index of health is observed in such category of women: high sick rate of gynecological or extragenital pathology, 3 times higher frequency of child's and respiratory illnesses, the surgical intervention on uterus and ovarium promotes the progress of the endometriosis. That the most frequent clinical manifestations of adenomyosis are pain and hemorrhagic syndrome. Conclusions. The clinical and statistical analysis of the examined patients made it possible to identify risk factors for the development of adenomyosis in women of reproductive age: burdened heredity (60%), unmarried and single women (58.5%); employees with intellectual and mental and neuropsychological stress (63.3%), high infection index, accompanying extragenital pathology (37.4%), menstrual cycle disorders (93.3%) and reduced reproductive and sexual function; aggravated gynecological history: chronic inflammatory processes of the uterus and appendages (44.2%), pathology of the cervix (36.5%), artificial (66.6%) and involuntary (14.4%) abortions; intrauterine surgical interventions (76.3%). The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.
Pelvic organ dysfunction in women with diastasis recti abdominis
Authors:   Ivano-Frankivsk National Medical University, Ukraine, Levytskyi I.V. , Kinash N.M. ,   Ivano-Frankivsk National Medical University, Ukraine, Kurtash N.Y. ,   Ivano-Frankivsk National Medical University, Ukraine
Published: September 2024

Diastasis rectus abdominis (DRM), pelvic organ dysfunction are common pathological conditions after pregnancy. Abdominal muscles are weakened with DRM, which leads to inefficient participation of the anterior abdominal wall in the processes of functioning of the main pelvic organs: bladder and rectum. Аim - to evaluate the main determinants of the development of DRM and to establish the relationship between the presence of diastasis and disorders of the pelvic organs in women who have given birth. Materials and methods. We analyzed pelvic organ disorders in 151 patients with diastasis recti abdominis. which were divided into types according to the Nahas classification. Type A diastasis recti abdominis in 21 (13.9%) patients, type B in 81 (53.6%), and types C/D in 49 (32.5%). The endpoint of the study was DRM: significance between its severity and potential pelvic organ disorders was assessed using Fisher's exact test or chi-square test for categorical variables. Results. The frequency of postpartum disorders depended on the severity of diastasis recti abdominis. In patients with type A, the frequency of pain/discomfort, urinary incontinence, and gas/liquid stool incontinence was 52.4%, 61.9%, and 66.7%, respectively. In patients with severe diastasis recti abdominis, the rates were 81.6%, 75.5%, and 79.6%, respectively. Excess weight and episiotomy during delivery were much stronger determinants than the severity of diastasis recti abdominis. The higher risk of the pelvic organ dysfunction was noted in older patients, active smokers, and those who developed gestational diabetes. Conclusions. The severity of DRM depends on age, body mass index, number of pregnancies, episiotomy during delivery, smoking, gestational diabetes. There is no strong dependency on delivery by cesarean section or the use of vacuum/forceps, nor on the presence of hypothyroidism in patients. The research was carried out in accordance with the principles of the Declaration of Helsinki. The research protocol was approved by the Local Ethics Committee of the institution mentioned in the work. Informed consent of the women was obtained for the research. The authors declare no conflict of interest.
Correlation of markers of maternal and fetal inflammation
Authors:   Municipal non-profit enterprise “Perinatal Center of Kyiv”, Ukraine, Bila V.V. ,   Bogomolets National Medical University, Kyiv, Ukraine, Zahorodnia O.S. ,   Bogomolets National Medical University, Kyiv, Ukraine
Published: September 2024

Fetal inflammatory response syndrome (IFRS) is an inadequate reaction of the fetal immune system to the inflammatory process in the placenta, which is accompanied by an increase in neonatal mortality and morbidity. Aim - to assess the dependence of IFRS on the markers of the inflammatory process of the mother in premature births in different gestational periods to determine the date of delivery. Materials and methods. 405 mothers with premature singleton deliveries and their premature newborns were examined. The Spearman correlation method was used to calculate the relationship between IL-6 content in the umbilical cord blood of a newborn and laboratory markers of maternal inflammation in peripheral blood (containing leukocytes and rod-shaped neutrophils, C-reactive protein, procalcitonin, pro-inflammatory interleukins), amniotic fluid (glucose, secretory inhibitor of leukocyte proteinase (SILP) and pro-inflammatory interleukins) and cervical mucus (pro-inflammatory interleukins). Results. Between the indicators of the mother's peripheral blood circulation and the value of IL-6, only a moderate connection was found, and the content of IL-6 in the amniotic fluid shows a strong correlation with the concentration of IL-6 in the umbilical cord blood of extremely premature newborns. For SILP, a strong correlation with the laboratory marker SFZV was found. A negative correlation with IL-6 of umbilical cord blood was found in cervical mucus for SILP. Signs of infection in the newborn show a strong dependence on the concentration of C-reactive protein and procalcitonin in the peripheral blood of the mother, but this was not found for extremely premature newborns. A strong correlation was found between the concentration of glucose in the amniotic fluid and signs of infection in premature infants in both gestational categories. Conclusions. Among indicators of peripheral blood circulation of a pregnant woman, none shows a strong correlation with IFRS. The concentration of SILP in the amniotic fluid has a strong correlation with signs of fetal inflammation, regardless of gestational age. The content of SILP in the cervical mucus has a strong negative correlation with the criterion of IFRS in preterm infants against the background of intact fetal membranes. A strong correlation between the glucose content in the amniotic fluid and signs of infection in the premature infant was revealed. For extremely premature newborns, no indicator of the mother's peripheral blood correlates with signs of infection. The research was carried out in accordance with the principles of the Declaration of Helsinki. The research protocol was approved by the Local Ethics Committee of the institution mentioned in the work. Informed consent of the women was obtained for the research. The authors declare no conflict of interest.
Perinatal features in recurrent herpesvirus infection
Authors:   Shupyk National Healthcare University of Ukraine, Kyiv, Anoshina T.M. , Kryvopustov S.P. ,   Bogomolets National Medical University, Kyiv, Ukraine, Batman Yu.A. ,   Bogomolets National Medical University, Kyiv, Ukraine,, Semenchenko O.I. ,   Shupyk National Healthcare University of Ukraine, Kyiv, Pysariev A.O. ,   Bogomolets National Medical University, Kyiv, Ukraine
Published: September 2024

The aim of the study is to determine perinatal features in recurrent herpesvirus infection (HVI). Materials and methods. 160 pregnant women and their newborns were examined: 100 women with recurrence during pregnancy of herpes simplex virus type 1 and/or 2 (HSV-1 and/or HSV-2), 30 women seropositive for HSV-1 and/or HSV-2 without relapse during pregnancy, 30 women seronegative for HVI. Peculiarities of the perinatal period and the development of children at 1 year of life were studied. The obtained data were processed by the methods of variational statistics, using the Student's t-test and Fisher's angular transformation. The Microsoft Excel statistical analysis package was used. Results. Recurrent HVI during pregnancy is associated with a significantly increased frequency of pregnancy complications (threat of abortion in 52.0% of women, threat of premature birth in 21.0%, anemia of pregnancy in 54.0%, placental insufficiency in 72.0%, fetal distress in 24.0%), childbirth (abnormalities of labor in 28.0%, fetal distress in 15.0%), postpartum blood loss (5.0%). Children are more often born prematurely (6.0%), in a state of asphyxia (24.0%), with reduced body weight (28.0%). In the structure of complications of the neonatal period, infections typical for the perinatal period, damage to the nervous system, respiratory distress syndrome prevail. In the period of life up to 1 year, a quarter of children belong to the group of frequently and long-term patients, 14.0% are underweight, and a third are overweight. One third had anemia, 14.0% had exudative diathesis, 24.0% had a syndrome of movement disorders and increased neuro-reflex excitability. Delayed motor development in combination with delayed reduction of muscle tone, delayed language development, game skills, and communication skills were noted. Conclusions. Recurrent HVI during pregnancy causes a high frequency of perinatal disorders, which requires preconception counseling and pregnancy management in order to avoid recurrences of GVI, prevent stressful situations, join infections, and correct the psycho-emotional state. The study was carried out in accordance with the main provisions of GCP ICH and the Declaration of Helsinki, agreed with the Local Ethics Committee of the institution. All studies were performed after obtaining the informed consent of the women. The authors declare no conflict of interest.
Coagulation characteristics of umbilical cord blood in fetal growth restriction
Authors:   Bogomolets National Medical University, Kyiv, Ukraine, Leush S.S. , Ter-Tumasova A.G. ,   Municipal non-profit enterprise “Perinatal Center of Kyiv”, Ukraine
Published: September 2024

Fetal growth restriction (FGR) is a common complication of pregnancy associated with severe perinatal consequences, a significant part of which is hemorrhagic and thrombotic disorders. Fetuses with FGR have thrombocytopenia, platelet dysfunction, and distortion of standard coagulation tests. There are few studies of the coagulation system in such newborns in vivo in the literature. Аim - to assess the relationship between the Doppler criteria of FGR and the kinetic manifestations of umbilical artery blood coagulation and fibrinolysis according to rotational thromboelastometry. Materials and methods. Prenatal Doppler parameters and postpartum kinetic parameters of blood coagulation and fibrinolysis in 118 newborns from singleton births were analyzed: the Group I - 67 newborns with FGR; the Group II - 51 full-term newborns from healthy mothers. Results. A significant decrease in the uterine and umbilical arteries resistance and blood flow velocity in FGR cases has been established. Thromboelastometric tests in the umbilical cord blood of the Group I newborns showed faster than in the Group II the blood clot formation, its greater firmness and delayed fibrinolysis. Comparison using rank correlation showed a relationship of average strength between the velocity of blood flow in the umbilical cord arteries and the blood clot firmness. Correlation between blood flow velocity in the midbrain and uterine arteries and coagulation indicators are weak. Conclusions. Reduced resistance index in the middle cerebral artery of fetuses with FGR indicates reduced resistance in these vessels, which should be regarded as signs of decentralization of fetal circulation. The blood of newborns with FGR is dominated by the processes of increased coagulation and slowing down of fibrinolysis, regardless of the date of birth. An increase in the pulsation index in the umbilical cord arteries during pregnancy can be considered a prognostically favorable hemodynamic characteristic in FGR. The study was carried out in accordance with the principles of the Helsinki Declaration. The research protocol was approved by the Local Ethics Committee of the institution mentioned in the work. The authors declare that there is no conflict of interest.
Nausea and vomiting of pregnancy: a review of modern opportunities
Authors:   Dnipro State Medical University, Ukraine, Petrenko Ye.V. , Bondarenko L.A. ,   Dnipro State Medical University, Ukraine
Published: September 2024

Nausea and vomiting of pregnancy (NVP) are the most frequent and characteristic symptoms of pregnancy for the first trimester that potentially may cause substantial negative consequences for the physical and emotional health of a woman. According to various studies, from 50 to 90% of women suffer from NVP. Usually, the symptoms of NVP begin at 5-6 weeks after the last menstrual period and disappear in most cases by the 16th-20th week of pregnancy, but sometimes they persist and may be observed until the third trimester, and in rare cases - even until childbirth. The doctor's main task in providing assistance to a pregnant woman with NVP is the timely application of an adequate treatment strategy, both effective and safe for a mother and a fetus, as well as ensuring the highest achievable life quality for a woman. The aim of this article is to analyze modern management opportunities for pregnant women with NVP, including an assessment of the advantages and disadvantages of different treatment strategies, for a comprehensive understanding of the NVP problem and the main principles and ways for solving it. This review is based on national guidelines (updated Royal College of Obstetricians and Gynecologists (RCOG) Green-top clinical guideline 2024, Society of Obstetricians and Gynecologists of Canada (SOGC) Guideline 2016), the results of various studies, and review articles (database of the Cochrane Library, UpToDate, EMBASE, MEDLINE). Conclusion: a combination of pyridoxine and doxylamine can be prescribed for the prevention of NVP since the diagnosis of pregnancy in a high-risk group of women. In case of already existing symptoms of NVP, the objective assessment of complaints, as well as a response to the prescribed therapy, are facilitated by the unified scales. In most cases, lifestyle modification and first-line drug therapy effectively reduce the severity of NVP symptoms and improve a woman's quality of life. In case of insufficient response, other drugs are added to the treatment regimen, including second and third-line drugs, with a consideration of possible drug interactions. Some patients might need admission, and in addition to antiemetic therapy, they might need intravenous rehydration, electrolyte balance restoration, and thromboprophylaxis. The authors declare that there is no conflict of interest.
The treatment strategy for giant neck teratoma in newborns: clinical case
Authors:   The First clinical Lviv association “St. Nicholas hospital”, Ukraine, Kalinchuk O.O. , Kulyk O.M. ,   Danylo Halytsky Lviv National Medical University, Ukraine, Dvorakevych A.O. ,   The First clinical Lviv association “St. Nicholas hospital”, Ukraine, Karpiv A.I. ,   Danylo Halytsky Lviv National Medical University, Ukraine
Published: September 2024

Teratoma can be diagnosed with ultrasound examination and screening, which is carried out in intrauterine period of the fetal development. Early diagnostics of the pathology is of the great importance of its treatment. The detailed management of newborns with giant neck teratoma have not been found in current literature. Furthermore, there is no information concerning preparation of the patient for the radical operation. The aim is to present the clinical case of surgical treatment of giant neck teratoma in newborn child using EXIT-procedure (intrauterine treatment to establish a functioning airway) and angiography before the radical excision of the tumor. The clinical case describes the diagnostics and treatment of newborn child with giant neck teratoma, who was taken to the first clinical Lviv association “St. Nicholas hospital”. The tumor was diagnosed intrauterine. The child underwent EXIT-procedure. Selective angiography and embolization of carotid branches were carried out on third day after birth. The surgical intervention regarding the removal of the tumor, which was removed radically with blood loss up to 50 ml, was performed on fourth day after birth. Conclusions. Prenatal screening with alpha-protein detection in mother blood is essential for diagnostics of probable pathologies of the fetal development. EXIT-procedure has led to save lung ventilation and effective support of the cardiovascular system. The selective angiography allowed to assess the bloodstream within branches of the internal carotid artery. The embolization of the branches of the external carotid artery, which vascularized the tumor, led to minimization of the blood loss up to 50 ml. As the removal of tumor was radical, further specialized treatment was not needed. The research was carried out in accordance to principles of the Helsinki declaration. The informed consent of the child’s parents was given for conducting the research. The authors declare no conflict of interest.
The FLIR One non-contact thermography application in the assessment of the burn wound depth
Authors:   Danylo Halytsky Lviv National Medical University, Ukraine, Farmaha T.I. , Lukavetskyi O.V. ,   Danylo Halytsky Lviv National Medical University, Ukraine, Chemerys O.M. ,   Danylo Halytsky Lviv National Medical University, Ukraine, Stoianovskyi I.V. ,   Danylo Halytsky Lviv National Medical University, Ukraine
Published: September 2024

The treatment of burn injuries is complicated by the proper diagnosis of areas requiring immediate necrectomy (deep burn) and those that can heal on their own (superficial burn). Non-contact thermography using the FLIR One device may be a reliable, non-invasive, and cost-effective method for assessing the depth of thermal injury. Aim - to study the temperature of healthy skin, deep and superficial burns using the FLIR One non-contact thermograph, the temperature difference between them, and the diagnostic value of the method for assessing burn depth. Materials and methods. The study involved 22 patients with limb burns. Thermometry of the affected areas was performed using the FLIR One thermograph within the first 48 hours after injury, before and during wound sanitation, with images analyzed using the FLIR One application. Results. The temperature of healthy skin was 34.7°C (34.4-35.1°C), the temperature of superficial burns was 35.8°C (35.5-36.2°C), and the temperature of deep burns was 32.4°C (32.0-32.8°C). The difference between healthy skin and deep burns was 2.3°C (2.2-2.4°C), and between superficial and deep burns was 3.4°C (3.0-3.8°C). A temperature of 33.7°C with non-contact thermography indicated a deep burn with 95% sensitivity and specificity. A decrease in the temperature of the affected skin by more than 2.0°C compared to healthy skin (2.2-2.4°C) or superficial burns (3.0-3.8°C) also indicated deep thermal damage. Conclusions. Thermography using FLIR One is a reliable and accessible method for analyzing the depth of burn wounds. The temperature of healthy skin during thermography is 34.7°C (34.4; 35.1)°C and is lower than the temperature of superficial burns (35.8°C (35.5; 36.2)°C) but higher than the temperature of deep burns (32.4°C (32.0; 32.8)°C). A temperature of 33.7°C with high sensitivity and specificity indicates a deep burn. The study showed that a temperature decrease of more than 2.0°C compared to healthy skin or superficial burns indicates deep thermal damage. The research was carried out in accordance with the principles of the Declaration of Helsinki. Informed consent of the child and child's parents was obtained for the research. The authors declare no conflict of interest.
Clinical aspects of diagnosis and prognosis of acute necrotic pancreatitis
Authors:   I.Horbachevsky Ternopil National Medical University, Ukraine, Banadyga A.I. , Banadyha N.V. ,   I.Horbachevsky Ternopil National Medical University, Ukraine
Published: September 2024

Aim - to evaluate diagnostic markers of acute pancreatitis. Materials and methods. The study was conducted in the period from 2014 to 2023 and was based on the assessment of the severity of acute pancreatitis (AP) in 237 patients. All patients were divided due to the severity of AP. Mild AP was detected in 85 (35.86%), moderate - in 90 (37.97%), severe - in 44 (18.56%), critical - in 18 (7.59%) patients. Also, two study groups were formed: the Group 1 (patients with mild and moderate AP) and the Group 2 (severe and critical AP). Results. The level of procalcitonin in the blood was increased in 29 (12.23%) patients of the Group 2 (severe and critical AP) and was >2.0 ng/ml. Among them in 25 (86.2%) patients early surgical treatment was perfomed and septic inflammation was detected in operating room. Typical ultrasound signs of AP were in 207 (87.34%) patients. Correlation roots between amylase and diastase on the first day of illness were: r=0,71 in the Group 1 and r=0.73 in the Group 2. Conclusions. The diagnosis of AP should be based on a comparative evaluation of the results of instrumental, laboratory tests and clinical symptoms. Levels of PCT, amylase, blood glucose, and urine diastase together with other clinical parameters helped to confirm the diagnosis of AP on admission to the hospital in 162 (92.57%) and 54 (87.09%) patients of the Group 1 and the Group 2. PCT should be used to predict complications and evaluate the efficiency of antibacterial therapy. The study was performed in accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the Local Ethics Committee for all participants. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.