bluuebunny/crossref_metadata_2025 huggingface dataset:
Nitric Oxide and a Conditioned Medium Affect the Hematopoietic Development in a Microfluidic Mouse Embryonic Stem Cell/OP9 Co-Cultivation System
Authors: Sato Kae , Maeda Momoko , Kamata Eriko , Ishii Sayaka , Yanagisawa Kanako , Kitajima Kenji , Hara Takahiko
Published: March 2020

A microfluidic co-culture system, consisting of mouse embryonic stem cells (mESCs)/OP9 cells, was evaluated as a platform for studying hematopoietic differentiation mechanisms in vitro. mESC differentiation into blood cells was achieved in a microchannel that had the minimum size necessary to culture cells. The number of generated blood cells increased or decreased based on the nitric oxide (NO) donor or inhibitor used. Conditioned medium from OP9 cell cultures also promoted an increase in the number of blood cells. The number of generated blood cells under normal medium flow conditions was lower than that observed under the static condition. However, when using a conditioned medium, the number of generated blood cells under flow conditions was the same as that observed under the static condition. We conclude that secreted molecules from OP9 cells have a large influence on the differentiation of mESCs into blood cells. This is the first report of a microfluidic mESC/OP9 co-culture system that can contribute to highly detailed hematopoietic research studies by mimicking the cellular environment.
A Comparative Study of Cavitation Characteristics of Nano-Fluid and Deionized Water in Micro-Channels
Authors: Li Tao , Liu Bin , Zhou Jinzhi , Xi Wenxuan , Huai Xiulan , Zhang Hang
Published: March 2020

Hydrodynamic cavitation has been widely applied in micro-fluidic systems. Cavitating flow characteristics are closely related to the fluid properties. In this paper, the cavitation characteristics of Cu nano-fluid in micro-channels were numerically investigated and compared with those of the deionized (DI) water. The mathematical model was verified by comparing the numerical results with the experiment observation. The curved orifice (R = 0.3 mm) was found to have the highest efficiencies of cavitation for both fluids. With the increase of inlet pressure, cavitating jet lengths of the two fluids significantly increased. While, the cavitating jet length of the nano-fluid was shorter than that of the DI water at the same inlet pressure. The cavitation inception number of the DI water and nano-fluid were approximately 0.061 and 0.039, respectively. The results indicate that the nano-particles played negative effects on the cavitation inception. In addition, with the decrease of outlet pressure, the cavitation strength gradually increased and the mass flow rate remained nearly unchanged at the same time.
Modeling and Experimental Study of Double-Row Bow-Type Micro-Displacement Amplifier for Direct-Drive Servo Valves
Authors: Liu Guoping , He Zhongbo , Bai Guo , Zheng Jiawei , Zhou Jingtao , Chang Ming
Published: March 2020

Giant magnetostrictive actuators (GMA) are widely used in the field of servo valves, but the displacement of GMA is limited, which renders meeting the requirements of large flow direct-drive electro-hydraulic servo valves (DDV) difficult. In order to solve these problems, this study proposes a double-row bow-type micro-displacement amplifier (DBMA), used to increase output displacement of GMA to meet the requirements. This study, by static analysis, analyzes the force of a flexure hinge based on theoretical mechanics and material mechanics, derives the stiffness matrix of the flexure hinge by the influence coefficient method, establishes the pseudo-rigid model, and derives the amplification ratio of a DBMA. Also, by kinetic analysis, using Castigliano’s second theorem, a formula of equivalent stiffness and natural frequency of DBMA were derived and the influences of different parameters on them were analyzed, respectively. After that, we analyzed the amplifier using finite element method (FEM) simulation software and verified the model by manufacturing a prototype and building a test system. Theoretical calculations and experimental results showed that the amplification ratio of the DBMA fluctuated between 15.43 and 16.25. The natural frequency was about 305 Hz to 314 Hz and the response bandwidth was up to 300 Hz. The error among the theoretical, simulated, and experimental values was within 8%, supporting the accuracy of the model.
Application of a Microfluidic Gas-to-Liquid Interface for Extraction of Target Amphetamines and Precursors from Air Samples
Authors: Collins Michael , Gel Murat , Lennard Chris , Spikmans Val , Forbes Shari , Anderson Alisha
Published: March 2020

The investigation of clandestine laboratories poses serious hazards for first responders, emergency services, investigators and the surrounding public due to the risk of exposure to volatile organic compounds (VOCs) used in the manufacture of illicit substances. A novel gas sampling interface using open microfluidic channels that enables the extraction of VOCs out of the gas phase and into a liquid, where it can be analysed by conventional detection systems, has recently been developed. This paper investigates the efficiency and effectiveness of such a gas-to-liquid (GTL) extraction system for the extraction of amphetamine-type substances (ATS) and their precursors from the vapour phase. The GTL interface was evaluated across a range of different ATS and their precursors (methamphetamine, dimethylamphetamine, N-formylmethamphetamine, benzaldehyde, phenyl-2-propanone, ephedrine and pseudoephedrine) at concentrations ranging between 10 and 32 mg m−3. These gas samples were produced by a gas generation system directly in Tedlar® bags and gas canisters for controlled volume sampling. When using gas sampled from Tedlar® bags, four of the seven compounds were able to be extracted by the GTL interface, with the majority of the VOCs having extraction yields between 0.005% and 4.5%, in line with the results from an initial study. When samples were taken from gas canisters, only benzaldehyde was able to be detected, with extraction efficiencies between 0.2% and 0.4%. A custom-built mount for the GTL interface helped to automate the extraction process, with the aim of increasing extraction efficiency or reducing variability. However, the extraction efficiency did not improve when using this accessory, but the procedure did become more efficient. The results from the study indicated that the GTL interface could be employed for the collection of gaseous ATS and incorporated into mobile detection systems for onsite collection and analysis of volatile compounds related to ATS manufacture.
There is No Distinctive Gut Microbiota Signature in the Metabolic Syndrome: Contribution of Cardiovascular Disease Risk Factors and Associated Medication
Authors: Cortés-Martín Adrián , Iglesias-Aguirre Carlos E. , Meoro Amparo , Selma María Victoria , Espín Juan Carlos
Published: March 2020

The gut microbiota (GM) has attracted attention as a new target to combat several diseases, including metabolic syndrome (MetS), a pathological condition with many factors (diabetes, obesity, dyslipidemia, hypertension, etc.) that increase cardiovascular disease (CVD) risk. However, the existence of a characteristic taxonomic signature associated with obesity-related metabolic dysfunctions is under debate. To investigate the contribution of the CVD risk factors and(or) their associated drug treatments in the composition and functionality of GM in MetS patients, we compared the GM of obese individuals (n = 69) vs. MetS patients (n = 50), as well as within patients, depending on their treatments. We also explored associations between medication, GM, clinical variables, endotoxemia, and short-chain fatty acids. Poly-drug treatments, conventional in MetS patients, prevented the accurate association between medication and GM profiles. Our results highlight the heterogeneity of taxonomic signatures in MetS patients, which mainly depend on the CVD risk factors. Hypertension and(or) its associated medication was the primary trait involved in the shaping of GM, with an overabundance of lipopolysaccharide-producing microbial groups from the Proteobacteria phylum. In the context of precision medicine, our results highlight that targeting GM to prevent and(or) treat MetS should consider MetS patients more individually, according to their CVD risk factors and associated medication.
Estimation Accuracy and Classification of Polymetallic Nodule Resources Based on Classical Sampling Supported by Seafloor Photography (Pacific Ocean, Clarion-Clipperton Fracture Zone, IOM Area)
Authors: Mucha Jacek , Wasilewska-Błaszczyk Monika
Published: March 2020

The amount and accuracy of nodule resources estimation in the Pacific Ocean are among the main factors conditioning the future exploitation. The estimates are based on the results of classical, direct seafloor sampling. Due to the large distance between sampling sites, the accuracy of assessing nodule resources in small parts of the deposit is low. The accuracy can be increased by using a large number of seafloor photographs taken along the route of the research vessel performing classic sampling. The study conducted for a part of the area administered by Interoceanmetal Joint Organization (IOM) included: (i) determining a model of the relationship between nodule abundance and seafloor nodule coverage using statistical methods, (ii) assessing the accuracy of nodule resources estimation using a geostatistical kriging procedure, (iii) proposing a preliminary classification of resources referring to International Seabed Authority (ISA) classification standards as material for further discussion. It was found that achievement of high accuracy in the estimation of nodule resources (with relative standard error <5%) in blocks planned for annual exploitation based on direct sampling is difficult. While the use of seafloor photographs increases the accuracy of estimating nodule resources, this improvement is not radical due to the unfavorable, preferential arrangement of photographic data.
Incorporation of Incompatible Strontium and Barium Ions into Calcite (CaCO3) through Amorphous Calcium Carbonate
Authors: Saito Ayaka , Kagi Hiroyuki , Marugata Shiho , Komatsu Kazuki , Enomoto Daisuke , Maruyama Koji , Kawano Jun
Published: March 2020

Calcite is a ubiquitous mineral in nature. Heavy alkaline-earth elements with large ionic radii such as Sr2+ and Ba2+ are highly incompatible to calcite. Our previous study clarified that incompatible Sr2+ ions can be structurally incorporated into calcite through crystallization from amorphous calcium carbonate (ACC). In this study, we synthesized Sr-doped calcite with Sr/(Sr + Ca) up to 30.7 ± 0.6 mol% and Ba-doped calcite with Ba/(Ba + Ca) up to 68.6 ± 1.8 mol%. The obtained Ba-doped calcite samples with Ba concentration higher than Ca can be interpreted as Ca-containing barium carbonates with the calcite structure which have not existed so far because barium carbonate takes the aragonite structure. X-ray diffraction (XRD) patterns of the Sr-doped and Ba-doped calcite samples obtained at room temperature showed that reflection 113 gradually weakened with increasing Sr/(Sr + Ca) or Ba/(Ba + Ca) ratios. The reflection 113 disappeared at Ba/(Ba + Ca) higher than 26.8 ± 1.6 mol%. Extinction of reflection 113 was reported for pure calcite at temperatures higher than 1240 K, which was attributed to the rotational (dynamic) disorder of CO32− in calcite. Our Molecular Dynamics (MD) simulation on Ba-doped calcite clarified that the CO32− ions in Ba-doped calcites are in the static disorder at room temperature. The CO32− ions are notable tilted and displaced from the equilibrium position of pure calcite.
Machine Learning Approach to Personality Type Prediction Based on the Myers–Briggs Type Indicator®
Authors: Amirhosseini Mohammad Hossein , Kazemian Hassan
Published: March 2020

Neuro Linguistic Programming (NLP) is a collection of techniques for personality development. Meta programmes, which are habitual ways of inputting, sorting and filtering the information found in the world around us, are a vital factor in NLP. Differences in meta programmes result in significant differences in behaviour from one person to another. Personality types can be recognized through utilizing and analysing meta programmes. There are different methods to predict personality types based on meta programmes. The Myers–Briggs Type Indicator® (MBTI) is currently considered as one of the most popular and reliable methods. In this study, a new machine learning method has been developed for personality type prediction based on the MBTI. The performance of the new methodology presented in this study has been compared to other existing methods and the results show better accuracy and reliability. The results of this study can assist NLP practitioners and psychologists in regards to identification of personality types and associated cognitive processes.
Platinum and Iridium Oxide Co-modified TiO2 Nanotubes Array Based Photoelectrochemical Sensors for Glutathione
Authors: Tian Jing , Zhao Peng , Zhang Shasha , Huo Guona , Suo Zhaochen , Yue Zhao , Zhang Shoumin , Huang Weiping , Zhu Baolin
Published: March 2020

Oriented TiO2 nanotubes, which are fabricated by anodic oxidation method, are prospective in photoelectrochemical analysis and sensors. In this work, Pt and IrO2 co-modified TiO2 nanotubes array was prepared via a two-step deposition process involving the photoreductive deposition of Pt and chemical deposition of IrO2 on the oriented TiO2 nanotubes. Due to the improved separation of photo-generated electrons and holes, Pt-IrO2 co-modified TiO2 nanotubes presented significantly higher PEC activity than pure TiO2 nanotubes or mono-modified TiO2 nanotubes. The PEC sensitivity of Pt-IrO2 co-modified TiO2 nanotubes for glutathione was also monitored and good sensitivity was observed.
Current-Resistance Effects Inducing Nonlinear Fluctuation Mechanisms in Granular Aluminum Oxide Nanowires
Authors: Barone Carlo , Rotzinger Hannes , Voss Jan Nicolas , Mauro Costantino , Schön Yannick , Ustinov Alexey V. , Pagano Sergio
Published: March 2020

The unusual superconducting properties of granular aluminum oxide have been recently investigated for application in quantum circuits. However, the intrinsic irregular structure of this material requires a good understanding of the transport mechanisms and, in particular, the effect of disorder, especially when patterned at the nanoscale level. In view of these aspects, electric transport and voltage fluctuations have been investigated on thin-film based granular aluminum oxide nanowires, in the normal state and at temperatures between 8 and 300 K. The nonlinear resistivity and two-level tunneling fluctuators have been observed. Regarding the nature of the noise processes, the experimental findings give a clear indication in favor of a dynamic random resistor network model, rather than the possible existence of a local ordering of magnetic origin. The identification of the charge carrier fluctuations in the normal state of granular aluminum oxide nanowires is very useful for improving the fabrication process and, therefore, reducing the possible sources of decoherence in the superconducting state, where quantum technologies that are based on these nanostructures should work.
On the Effects of Diluted and Mixed Ionic Liquids as Liquid Substrates for the Sputter Synthesis of Nanoparticles
Authors: Meischein Michael , Fork Marvin , Ludwig Alfred
Published: March 2020

The synthesis of nanoparticles by combinatorial sputtering in ionic liquids is a versatile approach for discovering new materials. Whereas the influence on nanoparticle formation of different pure ionic liquids has been addressed, the influence of (I) dilution of ionic liquid with solvents and (II) different mixtures of ionic liquids is less known. Therefore, mixtures of the ionic liquid [Bmim][(Tf)2N] with the organic solvent anisole and other ionic liquids ([Bmim][(Pf)2N], [BmPyr][(Tf)2N]) were used as liquid substrates for the sputter synthesis of nanoparticles, in order to investigate the influence of these mixtures on the size of the nanoparticles. First, mixtures of anisole with a suspension of sputtered Ag nanoparticles in [Bmim][(Tf)2N] were prepared in different volumetric steps to investigate if the stabilization of the NPs by the ionic liquid could be reduced by the solvent. However, a continuous reduction in nanoparticle size and amount with increasing anisole volume was observed. Second, Ag, Au and Cu were sputtered on ionic liquid mixtures. Ag nanoparticles in [Bmim][(Tf)2N]/[Bmim][(Pf)2N] mixtures showed a decrease in size with the increasing volumetric fraction of [Bmim][(Tf)2N], whereas all nanoparticles obtained from [Bmim][(Tf)2N]/[BmPyr][(Tf)2N] mixtures showed increasing size and broadening of the size distribution. Maximum sizes of sputtered Ag and Au NPs were reached in mixtures of [Bmim][(Tf)2N] with 20 vol.% and 40 vol.% [BmPyr][(Tf)2N]. The results indicate that ionic liquid mixtures with different portions of cations and anions have the capability of influencing the ionic liquid stabilization characteristics with respect to, e.g., nanoparticle size and size distribution.
Facile and Reliable Thickness Identification of Atomically Thin Dichalcogenide Semiconductors Using Hyperspectral Microscopy
Authors: Chang Yu-Chung , Wang Yu-Kai , Chen Yen-Ting , Lin Der-Yuh
Published: March 2020

Although large-scale synthesis of layered two-dimensional (2D) transition metal dichalcogenides (TMDCs) has been made possible, mechanical exfoliation of layered van der Waals crystal is still indispensable as every new material research starts with exfoliated flakes. However, it is often a tedious task to find the flakes with desired thickness and sizes. We propose a method to determine the thickness of few-layer flakes and facilitate the fast searching of flakes with a specific thickness. By using hyperspectral wild field microscopy to acquire differential reflectance and transmittance spectra, we demonstrate unambiguous recognition of typical TMDCs and their thicknesses based on their excitonic resonance features in a single step. Distinct from Raman spectroscopy or atomic force microscopy, our method is non-destructive to the sample. By knowing the contrast between different layers, we developed an algorithm to automatically search for flakes of desired thickness in situ. We extended this method to measure tin dichalcogenides, such as SnS2 and SnSe2, which are indirect bandgap semiconductors regardless of the thickness. We observed distinct spectroscopic behaviors as compared with typical TMDCs. Layer-dependent excitonic features were manifested. Our method is ideal for automatic non-destructive optical inspection in mass production in the semiconductor industry.
Border Trap Characterizations of Al2O3/ZrO2 and Al2O3/HfO2 Bilayer Films Based on Ambient Post Metal Annealing and Constant Voltage Stress
Authors: Rahman Md. Mamunur , Kim Dae-Hyun , Kim Tae-Woo
Published: March 2020

This study represents a comparison of the border trap behavior and reliability between HfO2 and ZrO2 films on n-In0.53Ga0.47As with an Al2O3 interfacial layer. The effect of different post metal annealing conditions on the trap response was analyzed and it was found that the N2:H2 mixed FGA passivates the border trap quite well, whereas N2-based RTA performs better on interface traps. Al2O3/HfO2 showed more degradation in terms of the threshold voltage shift while Al2O3/ZrO2 showed higher leakage current behavior. Moreover, Al2O3/ZrO2 showed a higher permittivity, hysteresis, and breakdown field than Al2O3/HfO2.
Advances in Emerging Solar Cells
Authors: Batmunkh Munkhbayar
Published: March 2020

There has been a continuous increase in the world’s electricity generation and consumption over the years [...]
Renewable Fabric Surface-Initiated ATRP Polymerizations: Towards Mixed Polymer Brushes
Authors: Raj Wojciech , Russo Alessandro , Zhang Yaoming , Chapelat Julien , Pietrasik Joanna
Published: March 2020

A totally new approach in the synthesis of mixed polymer brushes tethered on polyamide (PA) surfaces is presented herein. As a proof of concept, two types of homopolymers were synthesized in sequential surface-initiated atom transfer radical polymerization (SI-ATRP) reactions: poly(methyl methacrylate)/poly((2-dimethylamino)ethyl methacrylate) and polystyrene /poly((2-dimethylamino)ethyl methacrylate). The ATRP initiator was immobilized on the surface through PA chain-end groups in two subsequent steps, separated by homo-polymerizations. The amount of the PA chains’ end groups available on the modified surface was tuned by the thermal rearrangement of the surface.
Effect of the Lactococcus Lactis 11/19-B1 Strain on Atopic Dermatitis in a Clinical Test and Mouse Model
Authors: Suzuki Takato , Nishiyama Kyoko , Kawata Koji , Sugimoto Kotaro , Isome Masato , Suzuki Shigeo , Nozawa Ruriko , Ichikawa Yoko , Watanabe Yoshihisa , Suzutani Tatsuo
Published: March 2020

Some lactic acid bacteria (LAB) are known to improve atopic dermatitis (AD) through the regulation and stimulation of the host immune system. In this study, we found that ingestion of yogurt containing Lactococcus lactis 11/19-B1 strain (L. lactis 11/19-B1) daily for 8 weeks significantly improved the severity scoring of atopic dermatitis (SCORAD) system score from 38.8 ± 14.4 to 24.2 ± 12.0 in children suffering from AD. We tried to identify which LAB species among the five species contained in the test yogurt contributed to the improvement in AD pathology using an AD mouse model induced by repeated application of 1-fluoro-2, 4-dinitrobenzene (DNFB). AD-like skin lesions on the dorsal skin and ear were most improved by L. lactis 11/19-B1 intake among the five LAB species. In addition, analysis of CD4+ T cell subsets in Peyer’s patches (PPs) and cervical lymph nodes (CLNs) indicated that the intake of L. lactis 11/19-B1 generally suppressed all subsets related to inflammation, i.e., Th1, Th2 and Th17, instead of activating the suppressive system, Treg, in the AD mouse model. Histological observations showed ingestion of L. lactis 11/19-B1 significantly suppressed severe inflammatory findings, such as inflammatory cell filtration, epidermal erosion and eosinophil infiltration. These results suggest that the immunomodulatory effects of L. lactis 11/19-B1 contribute to improvements in AD pathology.
Nutrient Extraction Lowers Postprandial Glucose Response of Fruit in Adults with Obesity as well as Healthy Weight Adults
Authors: Alkutbe Rabab , Redfern Kathy , Jarvis Michael , Rees Gail
Published: March 2020

Fruit consumption is recommended as part of a healthy diet. However, consumption of fruit in the form of juice is positively associated with type 2 diabetes risk, possibly due to resulting hyperglycemia. In a recent study, fruit juice prepared by nutrient extraction, a process that retains the fiber component, was shown to elicit a favorable glycemic index (GI), compared to eating the fruit whole, in healthy weight adults. The current study expanded on this to include individuals with obesity, and assessed whether the nutrient extraction of seeded fruits reduced GI in a higher disease risk group. Nutrient extraction was shown to significantly lower GI, compared to eating fruit whole, in subjects with obesity (raspberry/mango: 25.43 ± 18.20 vs. 44.85 ± 20.18, p = 0.034 and passion fruit/mango (26.30 ± 25.72 vs. 42.56 ± 20.64, p = 0.044). Similar results were found in those of a healthy weight. In summary, the current study indicates that the nutrient-extraction of raspberries and passionfruit mixed with mango lowers the GI, not only in healthy weight individuals, but also in those with obesity, and supports further investigation into the potential for nutrient extraction to enable increased fruit intake without causing a high glycemic response.
Compliance with the 2018 World Cancer Research Fund/American Institute for Cancer Research Cancer Prevention Recommendations and Prostate Cancer
Authors: Rocío Olmedo-Requena , Macarena Lozano-Lorca , Inmaculada Salcedo-Bellido , Antonio Jiménez-Pacheco , Fernando Vázquez-Alonso , Marta García-Caballos , María-José Sánchez , José-Juan Jiménez-Moleón
Published: March 2020

The etiology of prostate cancer (PCa) remains largely unknown. Compliance with the 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRC/AICR) cancer prevention recommendations and its relationship to PCa was evaluated. A total of 398 incident PCa cases and 302 controls were included. The selection criteria for both cases and controls were: (i) age between 40–80 years; and (ii) residence in the coverage area of the reference hospitals for 6 months or more prior to recruitment. A score to measure the compliance with the recommendations of 2018 WCRC/AICR criteria was built. The level of compliance was used as a continuous variable and categorized in terciles. The aggressiveness of PCa was determined according to the ISUP classification. Adjusted odds ratios (aOR) and their 95% confidence intervals (95% CI) were estimated using multivariable logistic regression models. A slight protective tendency was observed between the level of compliance with the preventive recommendations and PCa risk, aOR = 0.81 (95% CI 0.69–0.96) for the total cases of PCa. This association also was observed when the aggressiveness was considered. In addition, limiting consumption of “fast foods”, sugar-sweetened drinks, and alcohol were independently associated with lower risk of PCa.
Dietary Assessment Methods in Military and Veteran Populations: A Scoping Review
Authors: Collins Rebecca A. , Baker Bradley , Coyle Daisy H. , Rollo Megan E. , Burrows Tracy L.
Published: March 2020

Optimal dietary intake is important for the health and physical performance of military personnel. For military veterans, the complex nature of transition into civilian life and sub-optimal dietary intake is a leading contributor to the increased burden of disease. A scoping review was undertaken to determine what is known about the assessment and reporting of dietary intakes within both military and veteran populations. In addition, this review determines if studies reporting on the dietary intake of military personnel or veterans include comparisons with dietary guidelines. Six databases were searched to identify papers published from the database inception to April 2019. Observational and intervention studies were searched to identify if they assessed and reported whole dietary intake data, reported data exclusively for a military or veteran population, and included only healthy populations. A total of 89 studies were included. The majority of studies used one dietary assessment method (n = 76, 85%) with fewer using multiple methods (n = 13, 15%). The most frequent methodology used was food frequency questionnaires (FFQ) (n = 40, 45%) followed by 24-hour recalls (n = 8, 9%) and food records (n = 8, 9%). The main dietary outcomes reported were macronutrients: carbohydrate, protein, fat, and alcohol (n = 66, 74%) with total energy intake reported in n = 59 (66%). Fifty four (61%) studies reported a comparison with country-specific dietary guidelines and 14 (16%) reported a comparison with the country-specific military guidelines. In conclusion, dietary intake in military settings is most commonly assessed via FFQs and 24-hour recalls. Dietary intake reporting is mainly focused around intakes of energy and macronutrients. Most studies compare against dietary guidelines, however, comparison to specific military dietary guidelines is minimal.
Muscle Strength and Glycaemic Control among Patients with Type 2 Diabetes
Authors: Bawadi Hiba , Alkhatib Dana , Abu-Hijleh Haya , Alalwani Joud , Majed Lina , Shi Zumin
Published: March 2020

Poor glycaemic control is associated with chronic life-threatening complications. This cross-sectional study examined whether there is an association between handgrip strength and glycaemic control among patients with diabetes. Data on 1058 participants aged 40 and older were collected from the National Health and Nutritional Examination Survey (NHANES). Muscle strength was assessed using a handgrip dynamometer, and glycaemic control was assessed using HbA1c. Handgrip strength was presented as age- and gender-specific quartiles, with participants in quartile 1 having the lowest handgrip strength and participants in quartile 4 having the highest handgrip strength. Logistic regression analyses were used to assess the association between handgrip strength and poor glycaemic control among participants with diabetes. Three models, each adjusted to include different variables, were employed. Odds ratio (OR) values revealed no association between handgrip strength and glycaemic control after adjusting for age, gender, and race in model 1. With further adjustment for sedentary activity, income-to-poverty ratio, education, and smoking, patients in quartile 4 of handgrip strength had 0.51 odds of poor glycaemic control (95% CI: 0.27–0.99). However, the reported association above vanished when further adjusted for insulin use (OR = 0.67; 95% CI: 0.35–1.28). In conclusion, findings may indicate an association between glycaemic control and muscle strength. This association may be altered by insulin use; further investigations are required.
Macronutrients in Parenteral Nutrition: Amino Acids
Authors: Iacone Roberto , Scanzano Clelia , Santarpia Lidia , Cioffi Iolanda , Contaldo Franco , Pasanisi Fabrizio
Published: March 2020

The right amount and quality of amino acids (AAs) supplied to patients on parenteral nutrition (PN) reduces muscle mass loss, may preserve or even increase it, with significant clinical benefits. Several industrial PN mixtures are available so that nutrition specialists can choose the product closest to the patient’s needs. In selected cases, there is the possibility of personalizing compounded mixtures in a hospital pharmacy that completely meets the individual nutritional needs of PN patients. This narrative review deals with the AA solutions used in PN mixtures. The physiology, the methods to calculate the AA needs, and the AA and energy requirements suggested by scientific guidelines for each patient type are also reported.
The Link between Hypermetabolism and Hypernatremia in Severely Burned Patients
Authors: Rugg Christopher , Ströhle Mathias , Schmid Stefan , Kreutziger Janett
Published: March 2020

Hypernatremia is common in critical care, especially in severely burned patients. Its occurrence has been linked to increased mortality. Causes of hypernatremia involve a net gain of sodium or a loss of free water. Renal loss of electrolyte-free water due to urea-induced osmotic diuresis has been described as causative in up to 10% of hypernatremic critical ill patients. In this context, excessive urea production due to protein catabolism acts as major contributor. In severe burn injury, muscle wasting occurs as result of hypermetabolism triggered by ongoing systemic inflammation. In this retrospective study, severely burned patients were analysed for the occurrence of hypernatremia and subsequent signs of hypermetabolism. The urea: creatinine ratio—as a surrogate for hypermetabolism—sufficiently discriminated between two groups. Four of nine hypernatremic burn patients (44%) had a highly elevated urea: creatinine ratio, which was clearly associated with an increased urea production and catabolic index. This hypermetabolism was linked to hypernatremia via an elevated urea- and reduced electrolyte-fraction in renal osmole excretion, which resulted in an increased renal loss of electrolyte-free water. In hypermetabolic severely burned patients, the electrolyte-free water clearance is a major contributor to hypernatremia. A positive correlation to serum sodium concentration was shown.
Association of Adherence to Specific Mediterranean Diet Components and Cardiorespiratory Fitness in Young Adults
Authors: Santi-Cano Mª José , Novalbos-Ruiz José Pedro , Bernal-Jiménez María Ángeles , Bibiloni María del Mar , Tur Josep A. , Rodriguez Martin Amelia
Published: March 2020

Objective: Cardiorespiratory fitness (CRF) and a healthy diet may be part of an overall healthy lifestyle. The association between cardiorespiratory fitness and adherence to an overall Mediterranean Diet (MedD) pattern and specific MedD foods has been assessed. Design: Subjects completed a lifestyle survey and dietary pattern, using the validated MedD Adherence 14-item questionnaire and two self-reported 24-h dietary recalls. Participants’ height, body weight, waist circumference (WC), and CRF (maximum oxygen uptake, VO2max, ml/kg/min) were measured. Setting: University of Cádiz, Spain. Subjects: A sample of young adults (n = 275, 22.2 ± 6.3 years). Results: Mean VO2max was 43.9 mL/kg/min (SD 8.5 mL/kg/min). Most participants had healthy CRF (75.9%). The average MedD score was 6.2 points (SD 1.8 points). Participants who consumed more servings of nuts had higher VO2max. Those who showed low CRF performed less physical activity (PA) and had a higher body mass index (BMI) and WC compared with those classified as having healthy CRF. Nut consumption was positively associated with VO2max (β = 0.320; 95% CI 2.4, 10.7; p < 0.002), adjusting for sex, age, smoking PA, BMI, WC, and energy intake, showing the subjects who consumed more nuts were fitter than young adults who consumed less. Conclusions: CRF is positively associated with nut consumption but not with the overall MedD pattern and all other MedD foods in the young adults. The subjects who consumed more servings of nuts were fitter than young adults who consumed less. Moreover, fitter subjects performed more PA and had a lower BMI and WC than those who had lower fitness levels.
Vitamin K Deficiency Bleeding in Infancy
Authors: Araki Shunsuke , Shirahata Akira
Published: March 2020

Vitamin K is essential for the synthesis of few coagulation factors. Infants can easily develop vitamin K deficiency owing to poor placental transfer, low vitamin K content in breast milk, and poor intestinal absorption due to immature gut flora and malabsorption. Vitamin K deficiency bleeding (VKDB) in infancy is classified according to the time of presentation: early (within 24 h), classic (within 1 week after birth), and late (between 2 week and 6 months of age). VKDB in infancy, particularly late-onset VKDB, can be life-threatening. Therefore, all infants, including newborn infants, should receive vitamin K prophylaxis. Exclusive breastfeeding and cholestasis are closely associated with this deficiency and result in late-onset VKDB. Intramuscular prophylactic injections reduce the incidence of early-onset, classic, and late-onset VKDB. However, the prophylaxis strategy has recently been inclined toward oral administration because it is easier, safer, and cheaper to administer than intramuscular injection. Several epidemiological studies have shown that vitamin K oral administration is effective in the prevention of VKDB in infancy; however, the success of oral prophylaxis depends on the protocol regimen and parent compliance. Further national surveillance and studies are warranted to reveal the optimal prophylaxis regimen in term and preterm infants.
Comparative Bioavailability of Different Coenzyme Q10 Formulations in Healthy Elderly Individuals
Authors: Pravst Igor , Rodríguez Aguilera Juan Carlos , Cortes Rodriguez Ana Belen , Jazbar Janja , Locatelli Igor , Hristov Hristo , Žmitek Katja
Published: March 2020

Coenzyme Q10 (CoQ10) plays a central role in mitochondrial oxidative phosphorylation. Several studies have shown the beneficial effects of dietary CoQ10 supplementation, particularly in relation to cardiovascular health. CoQ10 biosynthesis decreases in the elderly, and consequently, the beneficial effects of dietary supplementation in this population are of greater significance. However, most pharmacokinetic studies have been conducted on younger populations. The aim of this study was to investigate the single-dose bioavailability of different formulations of CoQ10 in a healthy geriatric population. A randomized, three-period, crossover bioavailability study was conducted on 21 healthy older adults (aged 65–74). The treatment was a single dose with a one-week washout period. Three different formulations containing the equivalent of 100 mg of CoQ10 were used: Q10Vital® water-soluble CoQ10 syrup (the investigational product—IP); ubiquinol capsules (the comparative product—CP); and ubiquinone capsules (the standard product—SP). Ubiquinone/ubiquinol was followed in the plasma for 48 h. An analysis of the ratio of the area under the baseline-corrected concentration curve (ΔAUC48) for total CoQ10 and a comparison to SP yielded the following: The bioavailability of CoQ10 in the IP was 2.4-fold higher (95% CI: 1.3–4.5; p = 0.002), while the bioavailability of ubiquinol (CP) was not significantly increased (1.7-fold; 95% CI: 0.9–3.1, p = 0.129). No differences in the redox status of the absorbed coenzyme Q10 were observed between formulations, showing that CoQ10 appeared in the blood mostly as ubiquinol, even if consumed as ubiquinone.
Products Derived from Buchenavia tetraphylla Leaves Have In Vitro Antioxidant Activity and Protect Tenebrio molitor Larvae against Escherichia coli-Induced Injury
Authors: Silva Tiago Fonseca , Cavalcanti Filho José Robson Neves , Barreto Fonsêca Mariana Mirelle Lima , Santos Natalia Medeiros dos , Barbosa da Silva Ana Carolina , Zagmignan Adrielle , Abreu Afonso Gomes , Sant’Anna da Silva Ana Paula , Lima Vera Lúcia de Menezes , Silva Nicácio Henrique da , Dutra Lívia Macedo , Almeida Jackson Roberto Guedes da Silva , Silva Márcia Vanusa da , Correia Maria Tereza dos Santos , Nascimento da Silva Luís Cláudio
Published: March 2020

The relevance of oxidative stress in the pathogenesis of several diseases (including inflammatory disorders) has traditionally led to the search for new sources of antioxidant compounds. In this work, we report the selection of fractions with high antioxidant action from B. tetraphylla (BT) leaf extracts. In vitro methods (DPPH and ABTS assays; determination of phenolic and flavonoid contents) were used to select products derived from B. tetraphylla with high antioxidant action. Then, the samples with the highest potentials were evaluated in a model of injury based on the inoculation of a lethal dose of heat-inactivated Escherichia coli in Tenebrio molitor larvae. Due to its higher antioxidant properties, the methanolic extract (BTME) was chosen to be fractionated using Sephadex LH-20 column-based chromatography. Two fractions from BTME (BTFC and BTFD) were the most active fractions. Pre-treatment with these fractions protected larvae of T. molitor from the stress induced by inoculation of heat-inactivated E. coli. Similarly, BTFC and BTFD increased the lifespan of larvae infected with a lethal dose of enteroaggregative E. coli 042. NMR data indicated the presence of aliphatic compounds (terpenes, fatty acids, carbohydrates) and aromatic compounds (phenolic compounds). These findings suggested that products derived from B. tetraphylla leaves are promising candidates for the development of antioxidant and anti-infective agents able to treat oxidative-related dysfunctions.
In Vitro Anti-Prostate Cancer Activity of Two Ebselen Analogues
Authors: Kaczor-Keller Katarzyna B. , Pawlik Anna , Scianowski Jacek , Pacuła Agata , Obieziurska Magdalena , Marcheggiani Fabio , Cirilli Ilenia , Tiano Luca , Antosiewicz Jedrzej
Published: March 2020

Scientific research has been underway for decades in order to develop an effective anticancer drug, and it has become crucial to find a novel and effective chemotherapeutics in the case of prostate cancer treatment. Ebselen derivatives have been shown to possess a variety of biological activities, including cytostatic and cytotoxic action against tumor cells. In this study, the cytotoxic effect and anticancer mechanism of action of two organoselenium compounds— (N-allyl-1,2-benzisoselenazol-3(2H)-one (N-allyl-BS) and N-(3-methylbutyl)-1,2-benzisoselenazol-3(2H)-one) (N-(3-mb)-BS)—were investigated on two phenotypically different prostate cancer cell lines DU 145 and PC-3. The influence of analyzed compounds on the viability parameter was also assessed on normal prostate cell line PNT1A. The results showed that both organoselenium compounds (OSCs) efficiently inhibited cancer cell proliferation, whereas normal PNT1A cells were less sensitive to the analazyed ebselen analouges. Both OSCs induced G2/M cell cycle arrest and prompted cell death through apoptosis. The detection of cleaved Poly (ADP-ribose) Polymerase (PARP) confirmed this. In addition, N-allyl-BS and N-(3-m)-b-BS increased the level of reactive oxygen species (ROS) formation, however only N-allyl-BS induced DNA damage. Based on our data, we assume that OSCs’ anticancer action can be associated with oxidative stress induction and inactivation of the Akt- dependent signalling pathway. In conclusion, our data demonstrate that ebselen derivatives showed strong cytotoxic efficiency towards prostate cancer cells and may be elucidated as a novel, potent anticancer agent.
A Samaritan Synagogue of the Byzantine Period at Apollonia-Arsuf/Sozousa?
Authors: Tal Oren
Published: March 2020

This article is a follow-up on an earlier publication of a bi-lingual Greek-Samaritan inscription discovered at the site of Apollonia-Arsuf (Sozousa) in Area P1 in 2014. It presents the yet unpublished results of an additional season of excavations carried out in 2015 around the structure where the inscription was unearthed. This season of excavations aimed at locating the remains of a presumed Samaritan synagogue building that, in our view, musts have housed this bi-lingual Greek-Samaritan inscription.
The Use of Bibliotherapy in Revealing and Addressing the Spiritual Needs of Cancer Patients
Authors: Bálint Ágnes , Magyari Judit
Published: March 2020

Assessing and addressing spiritual needs is a key factor in the quality of life and overall wellbeing of cancer patients. However, the evolution and diversification of assessment tools has not automatically been followed by their successful implementation; thus, addressing unmet needs continues to be a concern. In this paper, we examine the place of bibliotherapy (also called reading therapy or poetry therapy) as a group intervention in the oncological setting in revealing spiritual needs. We show that it represents not only a useful intervention but may also provide instant relief and reduce spiritual suffering. Bibliotherapy understood and practiced as a subtle balance of texts and group processes alleviates cognitive and emotional symptoms of a spiritual concern and facilitates finding meaning in life in general and illness in particular. As an intervention, it is effective, affordable and attractive; moreover, it equips patients receiving treatment and rehabilitation with the lifelong skill of reflective reading. Bibliotherapy is easily tailored to almost any needs and promotes self-expression, which provides spiritual fulfillment in itself.
Mean-Variance Optimization Is a Good Choice, But for Other Reasons than You Might Think
Authors: Rigamonti Andrea
Published: March 2020

Mean-variance portfolio optimization is more popular than optimization procedures that employ downside risk measures such as the semivariance, despite the latter being more in line with the preferences of a rational investor. We describe strengths and weaknesses of semivariance and how to minimize it for asset allocation decisions. We then apply this approach to a variety of simulated and real data and show that the traditional approach based on the variance generally outperforms it. The results hold even if the CVaR is used, because all downside risk measures are difficult to estimate. The popularity of variance as a measure of risk appears therefore to be rationally justified.
Pressure Injuries in the Healthcare Setting
Authors: Bisbee Janette
Published: March 2020

Background: The ultimate goal and purpose of healthcare is to improve health while preventing morbidity and mortality. The optimal approach to this is through teamwork using a reliability framework. Upon review of our institution’s 2012 patient safety culture survey data, we noted that the teamwork domain of the Agency for Healthcare Research and Quality (AHRQ) assessment was in the lowest decile. Our institution implemented the Crimson Analytics tool in 2013, and an analysis of inpatient mortality data revealed higher than expected mortality statistics.

Objective: Hospital systems and team-based care are more developed during daytime hours, leaving patients more vulnerable to adverse events (morbidity and mortality) during the overnight period. Our objective was to develop optimal transitions of care and proactive risk identification/mitigation through an interprofessional team-based approach, with resultant decrease in patient harm and improvement in safety culture.

Methods: In a community hospital, standardize transitions to identify “at risk” patients for nurses, physicians, and respiratory techs with subsequent interprofessional review of care plans/patient status in a centralized midevening standup briefing, subsequent proactive rounding on “at risk” patients, use of error prevention behaviors aimed to mitigate cognitive bias, and end-of-shift reflection process.

Results: Inpatient mortality rates fell from a baseline level of 2.08% in April 2013–March 2015 to 1.56% during the intervention period from April 2015–March 2018. The observed/expected mortality ratio fell from 1.04 to 0.76. AHRQ safety culture data improved in the team-work domain from 81% to 83%. A custom survey for this intervention was developed and found significant improvements in risk awareness and
mitigation response, teamwork, efficiency, and—potentially—joy at work.

Conclusion: An interprofessional approach to high-quality transitions in care, risk identification, and mitigation, along with structured huddles and proactive rounding, can improve patient safety at night while simultaneously improving staff satisfaction, joy, and safety culture.
Accurate Weight Documentation
Authors: Muzumdar Sonali
Published: March 2020

Background: The Institute for Safe Medication Practices (ISMP) has recommended that health systems implement preventive measures to decrease weight-based dosing errors.

Problem: Despite a process improvement project that was implemented to meet ISMP’s goals, weight documentation discrepancies continue to occur.

Methods: The weight documentation process was reviewed and safety gaps were identified. Pharmacists were notified when patients had greater than 15% weight documentation discrepancy. Notifications were tracked before, during, and after process improvements within the electronic health record (EHR).

Interventions: Streamlining of weight documentation fields within nursing assessments, locking of bed scales, setting an expiration date for the weight documentation field, including a minimum and maximum on height and weight fields, real-time alert for nursing staff upon documentation, and staff education were part of the process
improvement plan.

Results: Average monthly weight documentation errors decreased from 115 to 60 per month over the process improvement period.

Conclusion: Human factor errors can result in weight documentation discrepancies despite implementing ISMP’s targeted safety goals around weight documentation. A
real-time pharmacy notification of weight documentation discrepancies should be required for hospital pharmacists to prevent weight-based dosing errors.
“Célula de proteção comunitária”
Authors: Ferreira da Costa Aldemar , Pereira Barros João Paulo
Published: March 2020

O objetivo deste artigo é problematizar efeitos psicossociais da implantação da Célula de Proteção Comunitária (CPC) na região do Grande Jangurussu, na periferia de Fortaleza, tomando por base produções discursivas de jovens negros sobre tal dispositivo de segurança. Metodologicamente, a pesquisa foi realizada a partir de uma cartografia como método de pesquisa-inter(in)venção. Para responder a essas questões, recorreu-se a estudos foucaultianos sobre dispositivos de segurança, biopolítica e governamentalidade, estudos anti-coloniais sobre necropolítica e suas implicações em corpos negros e territorialidades periferizadas. Os resultados indicam que, orientando-se por uma racionalidade necro e biopolitica, tal implantação da Célula de Proteção Comuntiária tem implicado na produção do medo e da manutenção da lógica de controle sobre corpos e territórios racializados e historicamente estigmatizados.