bluuebunny/crossref_metadata_2025 huggingface dataset:
The decipherment of tissue-based proteome signatures revealed predictive biomarkers of diseases for primary Sjogren's syndrome with peripheral neuropathy system
Authors: Zhang Jiayu , Jin Ying , Xu Liying , Wang Yang , Zheng Jiaman , Li Wei , Chen Donghua , Jiang Haishan , Zheng Hui , Yuan Chao
Published: December 2023

Background and objectives
The peripheral neuropathy system in Primary Sjogren's syndrome (pSS-PNS) is often disregarded as a significant neuropathy, and there is limited research on the underlying pathological mechanisms. This study aimed to explore some possible processes by proteomic analysis.
Methods
Samples of the sural nerve were collected from patients diagnosed with pSS-PNS (n=3) and chronic inflammatory demyelinating polyneuropathy (CIDP) (control, n=3). A data-independent acquisition (DIA) proteomic analysis was used to detect differentially expressed proteins (DEPs). Functional annotation of DEPs and gene modules was performed using Gene Ontology (GO), Gene Set Enrichment Analysis (GSEA), Protein-protein interaction (PPI) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. The targeted proteins were validated using the parallel reaction monitoring (PRM) method.
Results
Samples of the sural nerve were collected from pSS-PNS patients (n=3) and CIDP patients (n=3)，and subjected to differential proteomic analysis (DIA). As a result, 187 proteins were found to be significantly regulated between pSS-PNS patients and the control group. 42 of these proteins were selected for quantification through parallel reaction monitoring (PRM), and five of them (F2, FGG, FN1, INA, FERMT3) displayed consistent expression patterns between DIA and PRM.
Conclusion
F2, FGG, FN1, INA, and FERMT3 exhibited differential expression in the sural nerves of patients with PNS secondary to Sjögren's syndrome (pSS-PNS). These genes have the potential to serve as diagnostic and therapeutic targets for pSS-PNS, and their pathogenesis may be linked to platelet activation.
Machinability investigation of 254 SMO super austenitic stainless steel in end milling under different cutting and lubri-cooling conditions
Authors: Passari Émerson S. , Souza André J. , Aita Carlos A. G.
Published: December 2023

The application of super austenitic stainless steels (SASS) in the petroleum, chemical, and naval industries has gradually increased owing to their intrinsic properties, such as corrosion resistance and durability. Consequently, the low machinability of SASS is due to its high mechanical strength, low thermal conductivity, and high tendency to work hardening. The present work analyzes the influence of different cutting and lubri-cooling conditions on machining forces, tool wear, surface roughness, and chip features produced during end milling of SASS 254 SMO. The results showed that depth of cut was the most influential parameter on static and dynamic machining forces, whereas the effect of cutting speed was low expressive. The nanofluid minimum quantity lubrication provided more stability in force values and lower tool failures on the peripheral cutting edge for the total machined length than in flood condition. In comparison, dry machining resulted in higher tool failure and machining forces. Low roughness values were generated on the sample surface because the end-cutting edge did not exhibit substantial failures. The lubricating effect of NMQL also improves the surface quality of the machined workpiece. On the other hand, dry machining resulted in adhered materials owing to high temperatures in the cutting zone and flood milling in removing material particles from the surface due to work hardening. Furthermore, the generated chips corroborated the analysis of the lubri-cooling effects on the machinability of the material, highlighting the higher temperatures produced during dry cutting owing to changes in the surface color of chips.
Application of Oblique Lumbar Interbody Fusion augmented with lateral vertebral screw for Adjacent Segment Disease: a retrospective study
Authors: Zhong Yuan , Wang Yujie , Chu Genglei , Chen Zhanhong , Li Renjie , Chentang Yiheng , Li Xuefeng , Liu Yijie , Jiang Weimin
Published: December 2023

Purpose: To evaluate the radiographic and clinical outcomes of oblique lumbar interbody fusion (OLIF) augmented with lateral vertebral screw fixation as revision surgery in adjacent segmental disease (ASD) treatment compared to transforaminal lumbar interbody fusion (TLIF) reoperation.
Methods: A retrospective study was conducted in the orthopedic department of Dushu Lake Hospital affiliated to Suzhou University from January 2019 to June 2023. Thirty patients with ASD underwent single segmental OLIF augmented with lateral vertebral rod-screw fixation, and another thirty-two individuals had extended TLIF surgery as a revision surgery. All patients’ baseline conditions were evaluated. The duration of the operation, intraoperative blood loss, and length of hospital stay were compared between the two groups. Radiographic and clinical outcomes were also evaluated by intervetebral disc height (IDH), intervetebral foraminal height (IFH), intervetebral foraminal area (IFA), crosssectional area of the spinal canal (CSA), thickness of ligmentum flavum (TL), Oswestry Disability Index (ODI), and visual analog scale (VAS).
Results: The duration of operation (63.06 ± 8.02 min vs. 150.30 ± 7.20 min, respectively; P <0.001) and intraoperative blood loss (66.66 ± 13.15 ml vs. 311.10 ± 40.83 ml, respectively; P <0.001) were significantly lower than those in the TLIF group. The hospital stay (6.03 ± 0.61 days vs. 12.91 ± 0.73 days, respectively; P <0.001) was also significantly shorter than that in the TLIF group. Both groups have shown a significant decrease in ODI and VAS scores after the procedure (P <0.001). But the ODI scores (11.93 ± 5.03 vs. 15.44 ± 3.65; P =0.0018) and VAS (back and leg) were lower in the OLIF group at last follow-up. In the OLIF group, all radiographic parameters have improved after the surgery.
Conclusion: OLIF augmented with lateral vertebral rod-screw fixation may have been found to be a safer, faster, and more effective way to treat ASD based on our early clinical and radiographic outcomes of this study.
Synthesis of SiO2@Ag nanocomposite for enhancing photoluminescence and Raman characterizations
Authors: Thai Dang Van , Pham Van Ben , Cong Doanh Sai , Huong Giang Nguyen Thi , Trong Duc Tran , Thi Ha Tran , Nguyen Tien-Thanh , Nguyen Tien Dai , Bui Hong Van
Published: December 2023

SiO2@Ag nanocomposite (NC) has been synthesized by the chemical reduction and Stӧber method for enhancement photoluminescence (PL) and Raman characteristics of Rhodamine 6G (R6G) and Malachite green (MG) dyes. As-synthesized SiO2@Ag nanocomposite indicated SiO2 nanosphere (NS) and Ag nanoparticle (NP) morphologies. The SiO2@Ag nanocomposite was high quality with a well-defined crystallite phase with average sizes of 24 nm and 132 nm for Ag NP and SiO2 NC, respectively. By using SiO2@Ag NC, the PL intensity of the R6G (at 59.17 ppm) was increased approximately 133 times. The surface-enhanced Raman spectroscopy (SERS) of the MG (at 1.0 ppm) with SiO2@Ag NC as substrate, clearly observed vibrational modes in MG dye at 798, 916, 1172, 1394, and 1616 cm− 1. As a result, the SERS enhancement factor (EFSERS) at 1172 cm− 1 obtained 6.3x106. This pioneering study points to the potential of SiO2@Ag nanocomposite as a promising material for effective photoluminescence and Raman characteristics at low-concentration dyes.
Prognostic impacts of the three AKT isoforms in acute myeloid leukemia. Is AKT3 the bad AKTOR?
Authors: Corre Eulalie , Soum Cécile , Pfeifer Romain , Bessière Chloé , Marboeuf Catherine , Meggetto Fabienne , Touriol Christian , Récher Christian , Bousquet Marina , Pyronnet Stéphane
Published: December 2023

The PI3K-AKT-mTOR pathway lies at the confluence of signaling pathways in which various components are subjected to activating genetic alterations in acute myeloid leukemia (AML), thus contributing to oncogenesis. Three AKT isoforms exist in humans. However, whether one isoform predominates in AML remains unknown. This study reveals that AKT3 behaves very distinctly than AKT1 or AKT2 in both normal myeloid differentiation and AML. During normal differentiation, AKT3 is preferentially expressed in hematopoietic stem cells whilst AKT1 becomes preferentially expressed as cells differentiate into granulocytes or monocytes. AKT2 expression remains unchanged. In AML, AKT3 expression varies widely among patient samples and is counterintuitively correlated to the expression of monocyte markers. Furthermore, a low level of AKT3 expression is strongly correlated to genetic alterations associated with a better outcome (NPM1 mutations and RUNX1-RUNX1T1 translocation), whilst a high level is correlated to a genetic alteration associated to a bad outcome (RUNX1 mutations). Neither AKT1 nor AKT2 expression associates with AML mutations or translocations. Consistently, a high AKT3 expression level appears as a very strong predictor of poor survival. Curiously, although modestly varying among AML samples, a high AKT1 expression shows in contrast as a strong predictor of a better patient outcome. These data suggest that AKT3 and AKT1 expressions have strong, yet opposite, prognostic values.
Extracorporeal Photopheresis Reduces Inflammation and Joint Damage in a Rheumatoid Arthritis Murine Model
Authors: Lin Yuwei , Cheng Zhanrui , Zhong Yan , Zhao Yinting , Xiang Guifen , Li Ling , Tian Li , Liu Zhong
Published: December 2023

Background: Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammatory reactions and tissue damage in the joints. Long-term drug use in clinical practice is often accompanied by adverse reaction. Extracorporeal photopheresis (ECP) is an immunomodulatory therapy with few side effects, offering a potential and safe therapeutic alternative for RA through the induction of immune tolerance. This study aimed to investigate the therapeutic effects of ECP on RA using a collagen-induced arthritis (CIA) murine model, as well as to explore its immunomodulatory effects in vivo. Additionally, particular attention was given to the significant role of monocytes during the ECP process.
Methods: A murine model of rheumatoid arthritis was established by administering two injections of bovine type II collagen to DBA/1J mice. ECP, ECP-MD (mononuclear cells were depleted during the ECP), MTX, and PBS treatment were applied to the CIA mice. During the treatment process, clinical scores and body weight changes of CIA mice were closely monitored. After six treatment sessions, micro-CT images of the hind paws from live mice were captured. Ankle joints and paws of the mice were collected and processed for histological evaluation. Spleen samples were collected to measure the Th17/Treg cells ratio, and serum samples were collected to assess cytokine and anti-type II collagen IgG levels.
Result: ECP therapy significantly attenuated the progression of CIA, alleviated the severity of clinical symptoms in CIA mice and effectively suppressed synovial hyperplasia, inflammation, and cartilage damage. There was an expansion in the percentage of CD3+CD4+CD25+FoxP3+ Tregs and a decrease in CD3+CD4+IL17A+ Th17 cells in vivo. Furthermore, ECP reduced the serum levels of pro-inflammatory cytokines IL-6 (53.47±7.074 pg/ml vs 5.142±1.779 pg/ml, P < 0.05) and IL-17A (3.077±0.401 pg/ml vs 0.238±0.082 pg/ml, P < 0.0001) compared with PBS. Interestingly, the depletion of monocytes during the ECP process did not lead to any improvement in clinical symptoms or histological scores in CIA mice. Moreover, the imbalance in the Th17/Treg cell ratio became even more pronounced, accompanied by an augmented secretion of pro-inflammatory cytokines IL-6 and IL-17A.
Conclusion: Our study demonstrates that ECP exhibits a therapeutic effect comparable to conventional therapy in CIA mice, and the protective mechanisms of ECP against RA involve Th17/Treg cells ratio, which result in decreased IL-6 and IL-17A. Notably, monocytes derived from CIA mice are an indispensable part to the efficacy of ECP treatment.
Detection of Stock Market Manipulation Using Deep Learning
Authors: B Hariharan , Goel Aadya , Garlyal Jaideep , Singh Adarsh Kumar , Kanojia Karnik , Paul Debasmita
Published: December 2023

The stock market is a vast trading environment that handles millions of transactions, making it challenging for regulatory bodies to identify fraudulent activities manually. However, unsupervised deep learning techniques provide a promising solution for detecting market manipulation. Inflating or deflating stock prices to gain an advantage is a form of market manipulation. We propose to examine how stock market manipulation can be detected using market structure analysis in the paper. The gathering of data involved utilizing information obtained from the websites of National Stock Exchange (NSE) and the Bombay Stock Exchange (BSE). The efficacy of an approach utilizing generative models is particularly noteworthy in this domain, showing significant potential for quickly identifying specific local irregularities in the data for anomaly detection and potential recognition of market manipulation. This efficiency addresses a common challenge faced by deep learning approaches. By exploring this matter, we aim to contribute insightful perspectives that could aid both investors and regulatory bodies in effectively understanding and managing the risks associated with stock market manipulation.
STAG2 mutations regulate 3D genome organization, chromatin loops, and Polycomb signaling in glioblastoma multiforme
Authors: Waldman Todd , Kim Jun-Sik , Xu Wanying , Yang Tianyi , Ya Alvin , Tallon Luke , Sadzewicz Lisa , Harris Brent , Sarkaria Jann , Jin Fulai
Published: December 2023

Inactivating mutations of genes encoding the cohesin complex are common in a wide range of human cancers. STAG2 is the most commonly mutated cohesin complex subunit. Here we report the impact of stable correction of endogenous, naturally occurring STAG2 mutations on gene expression, 3D genome organization, chromatin loops, and Polycomb signaling in glioblastoma multiforme (GBM). In two GBM cell lines, correction of their STAG2 mutations significantly altered the expression of ~10% of all expressed genes. Virtually all the most highly regulated genes were negatively regulated by STAG2 (i.e., expressed higher in STAG2-mutant cells than in STAG2-corrected cells), and one of them – HEPH – was regulated by STAG2 in uncultured GBM tumors as well. While STAG2 correction had little effect on large scale features of 3D genome organization (A/B compartments, TADs), STAG2 correction did alter thousands of individual chromatin loops, some of which controlled the expression of adjacent genes. Loops specific to STAG2-mutant cells, which were regulated by STAG1-containing cohesin complexes, were very large, supporting prior findings that STAG1-containing cohesin complexes have greater loop extrusion processivity than STAG2-containing cohesin complexes and suggesting that long loops may be a general feature of STAG2-mutant cancers. Finally, STAG2-regulated chromatin loops were enriched for the H3K27me3 Polycomb epigenetic mark, revealing that inactivation of STAG2 can activate Polycomb signaling in GBM, identifying a potential target for therapeutic intervention in STAG2-mutant tumors. Together, these findings illuminate the landscape of STAG2-regulated genes, A/B compartments, chromatin loops, and pathways in GBM, providing important clues into the largely still unknown mechanism of STAG2 tumor suppression.
Innovative dead-time correction and background subtraction for neutron multiplicity measurements using neural networks
Authors: Garcia-Duarte Jeremias , Harke Jason , Mishnayot Yonatan , Tamashiro Aaron , Lawrence Jackson
Published: December 2023

The number of neutrons emitted from a nuclear reaction plays a crucial role in various fields, including nuclear theory, nuclear nonproliferation, nuclear energy and nuclear criticality safety. Accurate determination of neutron multiplicities requires the application of several corrections, with dead-time correction and background subtraction being particularly significant. These corrections become more challenging for neutron detectors with time-dependent neutron capture. In this work, we perform a comprehensive study of three existing methods used for dead-time correction and background subtraction in neutron detectors with time-dependent neutron capture. The methods were tested for dead-times in the range from 0 to 1 μs using a Monte Carlo model simulating the dead-time and background effects in the standard neutron multiplicity probability distribution of 252Cf. The previous methods showed larger than desired uncertainty or systematic trade off. Those uncertainties prompted the development of a novel approach using neural networks trained with data from Monte Carlo simulations. The Neural Network method enabled the extraction of neutron multiplicity probabilities with accuracy ten times higher than the other methods with errors smaller than 1%. A similar approach using neural networks could be applied to problems where the system being studied can be accurately simulated without having an accurate analytical description available. The neural network method presented in this paper can easily be expanded if multiplicities are greater than 10.
Psy-E1, located at the same locus as Psy-A1, contributes strong yellowness to durum wheat but may cause yield loss in Japan.
Authors: Kato Keita , Ban Yusuke , Yanaka Mikiko , Okusu Hideki , Tanaka Tomoki , Kawakami Hiroyuki , Yamaguchi Masahiro , Funatsuki Wakako , Takata Kanenori , Ito Miwako
Published: December 2023

Strong yellow color, caused by carotenoid accumulation, in semolina flour made from durum wheat (Triticum turgidum L. subsp. durum (Desf.)) is one of the most important phenotypes for pasta production. The first step in the carotenoid biosynthesis pathway, which is catalyzed by phytoene synthase (PSY), is a bottleneck, and allelic variation of Psy-A1 in durum wheat produces different yellow pigment contents (YPC) in seeds. Durum wheat carrying leaf rust resistance gene LR19, which was translocated from wheat relative Thinopyrum ponticum chromosome 7E to durum wheat chromosome 7A, is known to produce high YPC, and the causal gene is presumed to be Psy-E1, which is tightly linked to LR19. In this study, Psy-E1 produced more YPC than the original Psy-A1 alleles in durum wheat, and YPC production decreased in the order of Psy-E1 > Psy-A1o > Psy-A1l > Psy-A1k. Segregation analysis demonstrated that Psy-E1 is located at the Psy-A1 locus on chromosome 7A. In a 2-year field test of near-isogenic materials, Psy-E1 was accompanied by yield loss with decreases in grain number per spike, volume weight and thousand-kernel weight under moisture conditions typical of wheat-growing areas of Japan. Thus, Psy-E1 has the potential to contribute high YPC in durum wheat breeding programs, although the applicable cultivation environments are limited.
Synthesis of black titanium dioxide/activated carbon composites for enhanced visible‐light photocatalytic properties
Authors: Li Jin , Jiang Zhaoxia , Li Jianfei , Li Boyang , Wang Xiaolian , Shi Qiwu
Published: December 2023

Black titanium dioxide (B-TiO2) formed by surface disorder engineering has attracted great attention due to its narrowed band gap, enhanced visible-light absorption, and various applications in photocatalysis, hydrogen production, photothermal conversion, etc. The hybrid of B-TiO2 with the other materials provides vast potential to improve it performance further. In this work, highly efficient visible-light-driven B-TiO2/activated carbon (AC) composite catalysts were synthesized by sol-gel method combined with argon heat treatment. The effect of AC content on the morphology, structure and optical properties of B-TiO2/AC was investigated. X-ray photoelectron spectroscopy (XPS) results showed a Ti-C- characteristic peak at 283.6 eV, which indicates the interaction between AC and B-TiO2. The photocatalytic experiments showed that the combination of 25wt% AC and B-TiO2 exhibited remarkable and stable photocatalytic performance for removing Rhodamine B (RhB). Particularly, under visible light irradiation (λ>420 nm), 82% of RhB was degraded within 60 minutes, which is 16% higher than B-TiO2 and 48% higher than white TiO2 (W-TiO2). Moreover, the RhB was degraded by 92% within 30 min under full-spectrum irradiation, which was 18% higher than B-TiO2 and 61% higher than W-TiO2. This work proposed a green and low-cost method for developing B-TiO2 based photocatalyst with improved performance.
ANCs of the bound states of 16O deduced from elastic α-12C scattering data
Authors: Ando Shung-Ichi
Published: December 2023

Asymptotic normalization coefficients (ANCs) of the $0_1^+$, $0_2^+$, $1_1^-$, $2_1^+$, $3_1^-$ ($l_{i th}^\pi$) bound states of $^{16}$O are deduced from the phase shift data of elastic $\alpha$-$^{12}$C scattering at low energies. $S$ matrices of elastic $\alpha$-$^{12}$C scattering are constructed within cluster effective field theory (EFT), in which both bound and resonant states of $^{16}$O are considered. Parameters in the $S$ matrices are fitted to the precise phase shift data below the $p$-$^{15}$N breakup energy for the partial waves of $l=0,1,2,3,4,5,6$, and the ANCs are calculated by using the wave function normalization factors of $^{16}$O propagators for $l=0,1,2,3$. We review the values of ANCs, which are compared with other results in the literature, and discuss uncertainties of the ANCs obtained from the elastic $\alpha$-$^{12}$C scattering data in cluster EFT.
Self-Organising Maps Applied to the Stratification of Preterm Birth Risk in Brazil with Socioeconomic Data
Authors: Lopes Márcio , Silva Lucileide , Silva Sérgio , Lima Waldenice , Barbosa Raquel , Fernandes Marcelo
Published: December 2023

Preterm birth (PTB) poses risks and difficulties for the survival of the newborn baby. Despite considerable progress in research, the causes of PTB still need to be fully understood. PTB risk is believed to be multi-faceted and may be linked to socioeconomic factors. This research aims to categorize the risk of PTB in Brazil based on socioeconomic data. To do this, it will use unsupervised machine learning techniques to identify clusters that show significant differences in PTB risk. By utilizing publicly accessible datasets from the Brazilian Federal Government, a new dataset was created with municipality-level socioeconomic information and a rate of PTB occurrence. This dataset was then processed with unsupervised learning techniques, such as self-organizing maps (SOM) and hierarchical clustering. The research uncovered clusters of municipalities with either high or low levels of PTB. Those with high PTB were mainly composed of municipalities with lower educational attainment, poorer quality of public services (e.g., sanitation and waste disposal), and a smaller white population. The analysis of the regional distribution of clusters revealed that the highest rates of PTB were mainly concentrated in Brazil's North and Northeast regions. The findings suggest that better quality of life and access to public services positively reduce the risk of PTB.
Differentiating diagnosis of atypical cardiac myxoma and thrombus by coronary computed tomography angiography imaging
Authors: Zhang Nannan , Lan Chuanqiang , Du Zeliu , Lin Guihan , Zhong Yi , Fei Jingle , Liu Kan , Ji Jiansong , Lu Chenying
Published: December 2023

Cardiac atypical myxoma usually presents as an isolated mass attached to the atrial septum on imaging, with no movement and a wider attachment base. It is difficult to distinguish it from cardiac thrombus through conventional echocardiography or computed tomography. The purpose of this study is to evaluate the value of coronary computed tomography angiography (CCTA) imaging features in distinguishing cardiac atypical myxoma from cardiac thrombus. This retrospective study included patients with atypical myxoma of the heart confirmed by histopathology (n = 18) and with thrombus disappearance after anticoagulation treatment (n = 23). All patients underwent CCTA examination. There are significant differences in the origin, surface, and enhancement patterns between cardiac myxoma and thrombus groups (p < 0.05, respectively). Specifically, supplied vessels were observed in the cardiac atypical myxoma group, while no neovascularization was detected in the thrombus group (83.33% vs. 0%, p < 0.001). Non-invasive CCTA can distinguish atypical cardiac myxoma and cardiac thrombus through image features, and will play an important role in the diagnosis and follow-up of future cardiac lesions.
Personalized embryo transfer guided by rsERT improves pregnancy outcomes in patients with repeated implantation failure
Authors: Li Ning , Zhang Yisheng , Li Rufei , Chen Yulin , Huang Lin , Tan Zhuojie , Ban Xiaoying , Zhou Ling , Xu Changlong , Qiu Ying , Li Rong
Published: December 2023

Background Embryo implantation requires synchronous communication between the embryo and maternal endometrium. Inadequate maternal endometrial receptivity is one of the principal causes of embryo implantation failure (especially repeated implantation failure (RIF)), when biopsied good-quality euploid embryos are transferred. An RNA-Seq-based endometrial receptivity test (rsERT) was previously established to precisely guide successful embryo implantation. Here, we aimed to evaluate the effect of personalized embryo transfer (pET) via rsERT on the clinical outcomes in patients with RIF. Methods 155 patients with RIF were included in the present retrospective study and were divided into two groups: 60 patients with rsERT and pET (Group rsERT), and 95 patients underwent standard frozen embryo transfer (FET) without rsERT (Group FET). Reproductive outcomes were compared for patients underwent rsERT guided pET and standard FET. Results 40% (24/60) of the patients underwent rsERT were receptive, and the remaining 60% (36/60) were non-receptive. The positive human chorionic gonadotropin (β-hCG) rate (56.3% vs. 30.5%, P = 0.003) and clinical pregnancy rate (43.8% vs. 24.2%, P = 0.017) were significantly higher in Group rsERT patients than those in FET group patients. Additionally, Group rsERT patients also showed higher implantation rate (32.1% vs. 22.1%, P = 0.104) and live birth rate (35.4% vs. 21.1%, P = 0.064) compared with FET patients, although without significance. For subpopulation analysis, the positive β-hCG rate, clinical pregnancy rate, implantation rate and live birth rate from receptive patients were not statistically significant different from those of non-receptive patients. Whether cleavage embryos or blastocysts were transferred, rsERT patients showed higher rates of positive β-hCG, clinical pregnancy, live birth and implantation, although these differences were not statistically significant. Conclusions The rsERT can significantly improve the pregnancy outcomes of patients with RIF, indicating the clinical potential of rsERT-guided pET.
DON6D: Decoupled One-stage Network for 6D Pose Estimation
Authors: Wang Zheng , Tu Hangyao , Qian Yutong , Zhao Yanwei
Published: December 2023

6D pose object estimation is a key task in robotic manipulation and grasping scenes. Many prior two-stage works with slower inference speeds require extra refinement to deal with challenge problems such as variations of lighting, sensor noise, object occlusion, and truncation. To address these problems, this work proposes a decoupled one-stage network (DON6D) for 6D pose estimation, which improves inference speed, on the premise of maintaining accuracy. Specifically, since RGB images are aligned with RGB-D images, DON6D first utilizes a 2D detection network to locate the interested objects in RGB-D images. Second, DON6D includes a module of feature extraction and fusion to fully extract color and geometric features. Furthermore, dual data augmentation is implemented to enhance the generalizability of the model. Third, DON6D fuses them and applies an attention residual encoder-decoder which can boost pose estimation performance to obtain accurate 6D pose. DON6D is a real-time method that is evaluated on the LINEMOD dataset and YCB-Video dataset. The results demonstrate that DON6D is superior to several state-of-the-art methods under the ADD(-S) metric and ADD(-S) AUC metric.
Population age as a key factor in the COVID-19 pandemic dynamics
Authors: Nesteruk Igor , Keeling Matt
Published: December 2023

The population and governments of many countries are losing interest in the SARS CoV-2 infection, the number of tests and the number of new cases detected is sharply decreasing. To compare the accumulated numbers CC of cases and deaths DC per million and to answer the question why the less vaccinated Africa has accumulated 36 times lower CC values and 15 times lower DC values than Europe, simple statistical analysis have been performed. CC and DC values demonstrated rather strong correlation with the median age of populations. One-year increment in the median year yields 12-18 thousand increase in CC values and 52-83 increase in DC values. Zero-COVID countries succeed to have much lower numbers of deaths per capita and case fatality ratios DC/CC.
Efficient Information Reconciliation in Quantum Key Distribution Systems Using Informed Design of Non-Binary LDPC Codes
Authors: Mitra Debarnab , Shreekumar Jayanth , Tauz Lev , Sarihan Murat Can , Wong Chee Wei , Dolecek Lara
Published: December 2023

In Quantum Key Distribution (QKD), two users extract a shared secret key using a quantum communication channel in the presence of an eavesdropper. Among QKD protocols, the ones based on Energy-Time (ET) entanglement of photons have been studied extensively due to their ability to generate high key rates from the arrival times of entangled photons. For the information reconciliation (IR) stage of ET-QKD protocols (where the users communicate using a classical channel in order to reconcile differences in their data), a scheme called multi-level coding (MLC) was proposed by Zhou et al. in prior work. The MLC scheme splits the raw key symbols into bit layers and utilizes binary Low-Density Parity-Check (LDPC) codes to encode each layer. Although binary LDPC codes are able to offer low complexity decoding for IR, they have poor error-correcting performance compared to their non-binary counterparts, thus leading to low key rates. Additionally, existing LDPC codes do not fully utilize the properties of the QKD channel to optimize the key rates. In this paper, we mitigate the above issues by proposing a flexible protocol for IR in ET-QKD systems called Non-Binary Multi-Level Coding NB-MLC(a) which is parameterized by a positive integer a. The NB-MLC(a) protocol is a generalization of the MLC scheme and utilizes NB-LDPC codes from a Galois field of size 2^a. We show that by using a small value of a, the NB-MLC(a) protocol significantly improves the key rate without much increase in complexity. To further improve the key rates of the NB-MLC(a) protocol, we propose i) a joint rate and degree distribution optimization (JRDO) algorithm to design the NB-LDPC codes for the protocol; ii) an interleaved decoding and communication (IDC) scheme to decode the different layers of the NB-MLC(a) protocol. The JRDO algorithm is designed to use the QKD channel information and we show that it results in a higher key rate than codes used in prior work. Additionally, the IDC scheme improves the key rate compared to the decoding and communication methods utilized previously in literature. Overall, the NB-MLC(a) protocol that uses JRDO LDPC codes and the IDC scheme results in a significant 40 − 60% improvement in key rates compared to prior work for ET-QKD systems.
Teneurin-4 as a potential prognosis biomarker in gastric adenocarcinoma: a proteomics analysis in endoscopic tissue biopsies
Authors: Chaves Renata Carvalho Miranda , Silva Roberto Afonso , Lima Iasmin Lopes , Dias Carlos Gabriel Monteiro , Junior Luiz Alberto Reis Mattos , Filho Jose Luiz Lima , Martins Danyelly Bruneska Gondim
Published: December 2023

PURPOSE: Gastric cancer remains a global health problem, which still needs a better understanding of its biology. Its incidence and prognosis rates in different geographic regions, as well as its pathogenesis, clinical presentation, genetic expressions and the presence of distinct mutations had an impact on the heterogeneous behaviors of patients. METHODS: Endoscopies with standard histological examination of biopsies and experimental analysis with tissue samples. Subjects were grouped according to their histopathologic grade of differentiations and submitted to a proteomic analysis. RESULTS: A total number of 1,103 proteins were identified among the control group and the three histological grades of gastric cancer specimens. ANOVA multiple sample test found a set of 356 proteins differentially expressed in at least one of the groups. Among the top 10 upregulated genes, teneurin-4 was found in all histological stages, which were related to histopathological grade of differentiation.
CONCLUSION: Teneurin-4 levels were upregulated in all grades of tumor differentiation, suggesting that teneurin-4 could be a candidate biomarker of gastric adenocarcinoma.
"It's Time to Live More Calmly, More Focused and Quieter..." : Pages of the Diary of Nicholas Gudzij. February – March 1924
Authors: Фролов М.А.
Published: December 2023

Публикация вводит в научный оборот страницы дневника литературоведа Н.К. Гудзия, относящиеся к февралю – марту 1924 г. Их историко-литературное значение об-условлено рядом причин: во-первых, отсутствием в довоенной части наследия ученого столь же подробных записей за другие годы, во-вторых, тем, что они документируют очень важный период научной активности Гудзия – его работу во II МГУ, Государственной Академии Художественных Наук и Обществе любителей российской словесности. Наконец, в-третьих – публикуемые записи фиксируют участие Гудзия в литературной жизни Москвы, его впечатления от встреч (полно обрисовывая ближайший круг его общения) и некоторые обстоятельства судьбы его трудов.

The publication introduces the pages of the diary of the literary critic N.K. Gudziy, relating to February – March 1924. Their historical and literary interest is due to several reasons: firstly, the absence of similarly detailed records for other years in the pre-war part of the scientist’s heritage, and secondly, the fact that they document a very important period of scientific Gudziy’s activity is his work at the 2nd Moscow State University, the State Academy of Artistic Sciences and the Society of Lovers of Russian Literature. Thirdly, the published notes record Gudziy’s participation in the literary life of Moscow, his impressions of meetings with people (fully describing the closest circle of his contacts), as well as some circumstances of the printed fate of his scientific works.
Efeito de extratos hidroetanólicos sobre mosca-das-frutas Ceratitis capitata (Wied., 1824) (Diptera: Tephritidae)
Authors: Santos Joseliane Fernandes Miguel dos , Lira Camila Cadete dos Santos , Silva Lucas Ferreira da , Silva Adelmo Ferreira , Costa Natanaelma Silva da , Silva Nadiane França da , Medeiros Marcos Barros de , Melo Djair Alves de
Published: December 2023

A mosca-das-frutas Ceratitis capitata (Diptera: Tephritidae) tem sido uma das principais pragas da fruticultura mundial. Este inseto é conhecido por provocar apodrecimento dos frutos, trazendo perdas significativas em pomares. O seu controle comumente é realizado por agroquímicos, porém devido aos impactos causados, surge a possibilidade de métodos alternativos de controle, que sejam eficazes, seletivos, com baixa toxicidade e eficiência. Posto isso, com essa pesquisa buscou-se avaliar o efeito de extratos hidroetanólicos, preparados com diferentes espécies vegetais, no controle de pupas de C. capitata, quando submetidas a diferentes concentrações. O experimento foi conduzido por meio de um delineamento inteiramente casualizado, com cinco espécies vegetais, sendo elas a aroeira (Schinus terebinthifolia), alho (Allium sativum), angico (Anadenanthera columbrina), cravo-da-índia, (Syzygium aromaticum) e embaúba (Cecropia pachystachya), utilizadas em diferentes concentrações (0%, 5%, 10%, 15% e 20%), sendo a concentração 0% o tratamento controle, com quatro repetições. A avaliação deu-se a partir da contagem do número de insetos emergidos durante nove dias. Os dados encontrados foram submetidos à análise de variância e as médias comparadas pelo teste de Tukey a 5% de probabilidade. Com relação aos extratos hidroetanólicos apenas o alho apresentou efeito de mortalidade sobre pupas de moscas-das-frutas, com eficácia na concentração de 5%. Dessa forma, conclui-se que o extrato de alho na concentração de 5% possui potencial bioinseticida para esse inseto-praga.
Factors related to children's participation in decision-making and activities: elementary and middle school students
Authors:   Korean Council For Children's Rights, Rim Sun Young , Lee Bong Joo
Published: December 2023

Objectives: This study aims to examine the actual status of children's participation, to subdivide factors related to child participation into children, families, schools, and communities, and to propose measures to activate child participation based on the results. Methods: Good Neighbors' “Child Rights Status Survey” data collected from a total of 8,864 elementary and middle school students and their parents (guardians) were used. SPSS 24.0 program was used to analyze child participation and related factors, and frequency analysis, t-test, and multiple regression analysis were conducted.
Results: Children's participation was examined focusing on decision-making participation and participation activities. The main relevant factors are as follows. Child factors were identified as significant factors in both the decision-making process participation and participation activity models, such as child recognition and discrimination experiences, family factors recognition of the child's rights agreement, school factors, and community factors such as the number of educational types and satisfaction with school life. Lack of access to information, respect for children's rights at home and in schools, and experience of corporal punishment at home were significant in the decision-making participation model, and the duration of child-friendly cities in the area where children live and the number of students per teacher were significant in the participation activity model.
Conclusions: To boost children's participation, the study proposes to strengthen children's awareness of rights, to prepare various educational programs, to strengthen child-led activities, to create a democratic family/school atmosphere, and to establish a community-level child participation system.
Perception of pediatrics through social big data
Authors:   Korean Council For Children's Rights, Park Yookyeong , Kim Daewoong
Published: December 2023

Objectives: The purpose of this study is to discover the perception of pediatrics as a topic. This study focuses on the perceptions of parents as potential consumers of pediatrics. Methods: We analyzed online community posts about pediatrics. 33,562 documents were analyzed in which ‘Pediatrics’ was mentioned among the posts for the four years from June 2020 to May 2023 were analyzed. The collected data were preprocessed and analyzed using text-mining techniques. Based on the TF value, the top 50 words were identified, a total of 18 topics were derived, and topic names were assigned.
Results: Discussions on medical institution treatment subjects, use and operation, children, recommendations, and diseases were prominent. There was a difference in topics according to the channel type. Online blogs were dominated by topics about healthcare referrals, while online cafes were dominated by topics about COVID-19, medical treatment, and medical expertise.
Conclusions: Based on the analysis results of this study, implications for the role of pediatricians and considerations for the treatment of children and families are suggested.
A qualitative study on the implementation status of local government's child policy: The child policy impact assessment and the south korean child policy initiative
Authors:   Korean Council For Children's Rights, Cho So Yeun , Kim Si Ah
Published: December 2023

Objective: The purpose of this study is to examine the implementation status of child policies in local governments and to derive improvement strategies.
Method: The researchers conducted interviews with 23 local government officials responsible for the ‘Child Policy Impact Assessment’ and the ‘South Korean Child Policy Initiative’. The data was analyzed using a generic qualitative research approach.
Results: The research results were categorized into two main themes: ‘Issues in the process of child policy implementation’ and ‘Alternatives for strengthening child policy implementation’. These themes were further subcategorized into ‘Alternatives for individual level ’, ‘‘Alternatives for organizational level’, and ‘Alternatives for implementation system level’. Furthermore, 18 concepts were identified according to the subcategories.
Conclusions: Based on the research findings, the study discusses key issues that are centered around the local government's child policy implementation structure, policy targets, evaluation indicators, and implementation procedures. Additionally, suggestions for improvement are presented, including standardization and guideline establishment for the implementation structure, and an implementation approach that integrates the ‘Child Policy Impact Assessment’ and the ‘South Korean Child Policy Initiative’.
Results of a multicenter study of the treatment of WNT medulloblastomas in children
Authors: Zheludkova O. G. , Olkhova L. V. , Ryzhova M. V. , Shishkina L. V. , Kushel Yu. V. , Melikyan A. G. , Gorelyshev S. K. , Golanov A. V. , Trunin Yu. Yu. , Vorobyov N. A. , Plakhotina N. A. , Boiko K. F. , Levashov A. S. , Polushkina O. B. , Korneev D. Yu. , Postnikova T. V. , Borodina I. D. , Kislyakov A. N. , Skobeev D. A. , Gorbatykh S. V. , Ozerov S. S. , Skorobogatova E. V. , Inyushkina E. V. , Popov V. E. , Mushinskaya M. V. , Kovalenko S. G. , Pogorelov D. N. , Yudina N. B. , Zaychikov A. N. , Bayramgulov R. R. , Sakun D. L. , Minkina L. M. , Matsekha E. P. , Tsyrenova N. V. , Grishina E. N. , Borisova M. V. , Matytsyn A. F. , Fedorova T. B. , Dinikina Yu. V. , Martynenko V. V. , Shapochnik A. P. , Yunusova I. M. , Mitrofanov V. A. , Rumyantsev A. A. , Fisyun I. V. , Timofeeva V. N. , Shamin A. V. , Markovsky A. M. , Bykova G. V. , Popova N. A. , Kochukova N. V. , Ostanina E. A. , Pshenichnikova A. A.
Published: December 2023

Medulloblastomas of the WNT molecular group (MB-WNT) represent the smallest group of MB and account for only 10 % of the total. This molecular group is characterized by a favorable prognosis. Given the aggressive treatment regimens for MB, reducing the intensity of therapy for prognostically favorable tumors seems justified. Purpose of the study – to demonstrate the results of treatment of children with MB-WNT and to determine the impact on survival of various prognostic factors. The study included 85 patients with MB-WNT under the age of 18 who received treatment and were followed up from 1993 to 2022. Median age at diagnosis was 10 years (min – 3, max – 17). All patients had classical MB. Metastatic spread of the tumor at the time of diagnosis was detected in 18 (21.2 %) patients, the presence of a residual tumor according to postoperative magnetic resonance imaging – in 32 (37.7 %). Somatic mutations in the TP53 gene were detected in 10 (7.1 %) patients, in the CTNNB1 gene – in 79 (92.9 %), in the APC gene – in 5 (5.9 %), chromosome 6 monosomy – in 76 (89.4 %) children. At the time of the analysis, 74 (87.1 %) patients were alive, 11 (12.9 %) patients died, a relapse was diagnosed in 6 (7.1 %) patients, of which 5 died from disease progression, 1 patient is alive in the second remission. One patient in long-term remission developed secondary meningioma 20 years after the diagnosis of MB. The 10-year progression-free survival (PFS) was 0.92. 5-year overall survival (OS) was 0.90, 10-year – 0.86. The median OS is 112 months. When analyzing the sample of patients with MB-WNT in our study, PFS and OS were statistically significantly higher in girls without metastatic tumor spread, with total resection of the tumor, stratified into the low-risk group, and in the absence of a somatic mutation in the TP53 gene in the tumor tissue. In multivariate analysis, PFS was influenced by the stage of the disease and the presence of a somatic mutation in the TP53 gene in the tumor tissue; on OS – only the presence of a somatic mutation in the TP53 gene in the tumor tissue.
Primary Ewing’s sarcoma of the kidney: description of two rare clinical cases and review of world literature
Authors: Romantsova O. M. , Panarina V. Yu. , Bolokhonova M. A. , Khairullova V. V. , Khestanov D. B. , Efimova M. M. , Panferova T. R. , Ignatenko O. A. , Kozlov N. A. , Stroganova A. M. , Kirgizov K. I. , Varfolomeeva S. R.
Published: December 2023

Ewing’s sarcoma (ES) of the kidney is an extremely rare malignant tumor characterized by an aggressive course, and therefore the disease has an unfavorable prognosis. Due to the rare occurrence, standards for the treatment of ES of the kidney have not been developed; an integrated approach is often used in therapy. In this article, we present a description of two clinical cases of kidney damage with ES in patients aged 10 and 16 who were treated at the Research Institute of Pediatric Oncology and Hematology named after Academician of the Russian Academy of Medical Sciences L.A. Durnov at N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia. In the first case, there was a metastatic lesion of the kidney with the localization of the primary focus in the pelvic bones, in the second, primary ES of the kidney was diagnosed. Both patients had stage IVb at the time of diagnosis (TNM classification American Joint Commission on Cancer). In both patients, after induction chemotherapy, a complete therapeutic response (complete therapeutic pathomorphosis) was obtained. In an integrated approach, in addition to standard chemotherapy, surgery and radiation therapy, in both cases, high-dose chemotherapy with autologous peripheral stem cell transplantation was used, which made it possible to create favorable conditions for long-term remission in one of the patients, even despite the initial prevalence of the process.