bluuebunny/crossref_metadata_2025 huggingface dataset:
Right ventricular–pulmonary artery coupling in chronic thromboembolic pulmonary hypertension
Authors: Bartnik Aleksandra , Pepke-Zaba Joanna , Hoole Stephen P , White Paul , Garbi Madalina , Coghlan John G , Taghavi Fouad , Tsui Steven , Weir-McCall Jonathan
Published: December 2022

Chronic thromboembolic pulmonary hypertension occurs in a proportion of patients with prior acute pulmonary embolism and is characterised by breathlessness, persistently raised pulmonary pressures and right heart failure. Surgical pulmonary endarterectomy (PEA) offers significant prognostic and symptomatic benefits for patients with proximal disease distribution. For those with inoperable disease, management options include balloon pulmonary angioplasty (BPA) and medical therapy. Current clinical practice relies on the evaluation of pulmonary haemodynamics to assess disease severity, timing of and response to treatment. However, pulmonary haemodynamics correlate poorly with patient symptoms, which are influenced by right ventricular tolerance of the increased afterload. How best to manage symptomatic patients with chronic thromboembolic pulmonary disease (CTEPD) in the absence of pulmonary hypertension is not resolved.

Right ventricular–pulmonary artery coupling (RV-PAC) describes the energy transfer within the whole cardiopulmonary unit. Thus, it can identify the earliest signs of decompensation even before pulmonary hypertension is overt. Invasive measurement of coupling using pressure volume loop technology is well established in research settings. The development of efficient and less invasive measurement methods has revived interest in coupling as a viable clinical tool. Significant improvement in RV-PAC has been demonstrated after both PEA and BPA. Further studies are required to understand its clinical utility and prognostic value, in particular, its potential to guide management in patients with CTEPD. Finally, given the reported differences in coupling between sexes in pulmonary arterial hypertension, further work is required to understand the applicability of proposed thresholds for decoupling in therapeutic decision making.
Dose–response correlation for CAR-T cells: a systematic review of clinical studies
Authors: Rotte Anand , Frigault Matthew J , Ansari Ayub , Gliner Brad , Heery Christopher , Shah Bijal
Published: December 2022

The potential of chimeric antigen receptor (CAR) T cells to successfully treat hematological cancers is widely recognized. Multiple CAR-T cell therapies are currently under clinical development, with most in early stage, during which dose selection is a key goal. The objective of this review is to address the question of dose-dependent effects on response and/or toxicity from available CAR-T cell clinical trial data. For that purpose, systematic literature review of studies published between January 2010 and May 2022 was performed on PubMed and Embase to search clinical studies that evaluated CAR-T cells for hematological cancers. Studies published in English were considered. Studies in children (age <18 years), solid tumors, bispecific CAR-T cells and CAR-T cell cocktails were excluded. As a result, a total of 74 studies met the inclusion criteria. Thirty-nine studies tested multiple dose levels of CAR-T cells with at least >1 patient at each dose level. Thirteen studies observed dose-related increase in disease response and 23 studies observed dose-related increase in toxicity across a median of three dose levels. Optimal clinical efficacy was seen at doses 50–100 million cells for anti-CD19 CAR-T cells and >100 million cells for anti-BCMA CAR-T cells in majority of studies. The findings suggest, for a given construct, there exists a dose at which a threshold of optimal efficacy occurs. Dose escalation may reveal increasing objective response rates (ORRs) until that threshold is reached. However, when ORR starts to plateau despite increasing dose, further dose escalation is unlikely to result in improved ORR but is likely to result in higher incidence and/or severity of mechanistically related adverse events.
Contributions of Hippocratic medicine and Plato to today’s debate over health, social determinants and the authority of biomedicine
Authors: Levin Susan B
Published: December 2022

By exploring a competition for authority on health and human nature between Plato and Hippocratic medicine, this paper offers a fresh perspective on an overarching debate today involving health and the role of healthcare in its safeguarding. Economically and politically, healthcare continues to dominate the USA’s handling of health, construed biophysically as the absence of disease. Yet, notoriously, in major health outcomes, the USA fares worse than other countries in the Organisation for Economic Co-operation and Development (OECD). Clearly, in giving pre-eminence to healthcare, the USA is doing far less than it could to protect and improve health. Meanwhile, mounting evidence supports the view that health impacts of social determinants besides healthcare (eg, education) surpass healthcare in heft. Circumscribed shifts in the USA’s current frame will not suffice: what’s needed is a change in its overall template for addressing health. Unless this is widely seen, the sway of biomedicine will likely be reduced slowly, if at all. That biomedicine’s role in relation to health is raised increasingly as aquestionis a sign that its ongoing supremacy is not a forgone conclusion. But making the most of this opportunity requires appreciating that ‘How should health’s relationship to medicine be conceptualised?’ is not the most fundamental query that we need to pose. Through consideration of Hippocratic medicine and Plato, I argue that the most availing answer to this particular question can come only after exploration of three larger questions involving health’s status as a human good and its relationship to human flourishing. Exploration of the Greeks is, thus, valuable methodologically. What’s more, it supports today’s advocacy of ‘health promotion’, a perspective tying health closely to well-being that has yet to achieve the overall prominence that it warrants.
Structures and dissociation of iron porphyrin complexes by ion mobility and collision-induced dissociation mass spectrometry
Authors: Gholami Ameneh , Hampe Oliver , Mayer Paul M.
Published: December 2022

A combination of ion mobility mass spectrometry (IMS-MS), collision-induced dissociation (CID), Rice–Ramsperger–Kassel–Marcus modeling, and computational chemistry was used to determine the structure and unimolecular chemistry of dimeric and trimeric sulfonated meso-tetraphenylporphyrins with negative charges from −2 to −5. By comparing experimental collision cross sections obtained from calibrated IMS drift times with calculated cross sections for the lowest energy calculated structures, it was confirmed that dimer species have a bridged structure where the two monomers are connected through iron–sulfonic interactions. Dimer species with the charge states −4 and −5 dissociate into two monomer units where the charge is distributed between the monomers. Dimers with lower charge states also lose neutral SO2 and SO3 groups. For trimeric species with charge states of −3 and −4, IMS identifies three and two isomers, respectively. It was confirmed that the −4 charged trimer isomers consist of one with three stacked monomers and one in which the third monomer unit is connected to a stacked dimer via two iron–sulfonic bonds (bridged/stacked). Both yielded the same CID breakdown diagram confirming that the two isomers likely interconvert prior to dissociation. The significantly larger density of states of the bridged–stacked structure compared with the stacked structure means the former is likely the reactive configuration.
Intersystem crossing and intramolecular triplet excitation energy transfer in spiro[9,10-dihydro-9-oxoanthracene-10,2′-5′,6′-benzindan] investigated by DFT/MRCI methods
Authors: Metz Simon , Böhmer Tobias , Raunitschke Ben , Marian Christel M.
Published: December 2022

Recent experimental studies of a spiro-linked anthracenone (A)–naphthalene (N) compound (AN) in butyronitrile (BuCN) solution (Dobkowski et al., J. Phys. Chem. A 2019, 123, 6978) proposed an excited-state energy dissipation pathway [1ππ* (N) + 1ππ*(A)]↝1 nπ* (A)↝3 nπ* (A)↝3ππ*(N). However, a detailed theoretical study employing combined density functional theory and multireference configuration interaction methods, performed in the present work, suggests that the photoexcitation decay follows a different pathway. In BuCN solution, the intersystem crossing (ISC) follows the well-established El-Sayed rule and involves the 3ππ*(A) state which is found to be the lowest excited triplet state localized on the anthracenone moiety. Because the Dexter triplet excitation energy transfer (TEET) to the first excited triplet state of the naphthalene subunit is forbidden in C2 v symmetry, it is mandatory to go beyond the Condon approximation in modeling this process. Nonadiabatic coupling matrix elements were computed to obtain a TEET rate different from zero. Our calculations yield time constants of 5 ps for the 1 nπ* (A)↝3ππ* (A) ISC and of 3 ps for the subsequent 3ππ* (A)↝3ππ* (N) TEET in BuCN whereas the energy dissipation involving the 3 nπ*(A) state as an intermediate occurs on a much longer time scale.
Polypyridine-based architectures for smart electrochromic and energy storage materials
Authors: Laschuk Nadia O. , Ebralidze Iraklii I. , Zenkina Olena V.
Published: December 2022

The emerging role of metal–organic coordination compounds in the development of electrochromic materials (ECMs) fueled a growing interest in both the development of the new systems and their effective integration into functional devices. Coordination complexes of late transition metals with polypyridine ligands, like 2′-bipyridine (bpy) and 2,2′:6′,2″-terpyridine (tpy) often feature bright colours as a result of strong metal-to-ligand charge transfer. These colours could be reversibly bleached by oxidation of the metal centre and restored upon the metal centre reduction. The colour and its intensity can be controlled in different ways: by changing the nature of the metal centre(s) and by structural modification of ligand(s); by the construction of various metal–organic motifs and embedding them into devices, as well as by controlled layer-by-layer growth of the coordination assemblies on the surface of interest. The versatility of the available molecular building blocks allows for the systematic programming of the desired properties of the metal–organic units that could be effectively translated into the devices. This makes polypyridine metal complexes advantageous candidates for the design of effective ECMs. Here, we review the evolution of ECMs and devices based on molecularly defined bpy and tpy coordination adducts of late transition metals integrated into functional electrochromic devices over the past decade.
Simplified models of vector SU(4) leptoquarks at the TeV
Authors: Barbieri Riccardo , Cornella Claudia , Isidori Gino
Published: December 2022

Assuming confirmation of the anomalies in semi-leptonic B-decays, their explanation in terms of the exchange of a massive vector leptoquark field, $$U_{\mu }^a$$

U

μ

a

, of charge 2/3, appears to require the inclusion of $$U_{\mu }^a$$

U

μ

a

in the vector multiplet of the adjoint of Pati–Salam SU(4), $${\mathcal {G}}_{\mu }^A$$

G

μ

A

, as well as the introduction of vector-like fermions, $$F_j$$

F
j

, in the fundamental of SU(4). We consider simplified models characterised by the nature of the SU(4) symmetry (global or local), by the number of vector-like fermions, and by the couplings of the Higgs boson to SM fermions (direct or induced by mixing with the vector-like fermions). In all cases, we implement a minimal breaking of a $$U(2)^n_f$$

U

(
2
)

f
n

flavour symmetry, with a single motivated exception. We then perform a global fit including the main observables sensitive to exchanges of the $${\mathcal {G}}_{\mu }^A$$

G

μ

A

at tree level and in loops dominated by logs insensitive to the UV completion.
The ∂̄-Neumann problem and boundary integral equations
Authors: Liu Bingyuan
Published: December 2022

In this paper, we find an equivalent boundary integral equation to the classical [Formula: see text]-Neumann problem. The new equation contains an equivalent regularity to the global regularity of the [Formula: see text]-Neumann problem. We also use the integral equations to observe a new-found rigidity property of the [Formula: see text]-Neumann problem on the unit ball in [Formula: see text].
Anisotropic compact stars with Tolman 𝕍 solution in f(ℛ,𝒯2) gravity
Authors: Sharif M. , Akram H. M. Salman
Published: December 2022

The main purpose of this paper is to study the physical characteristics and stability of anisotropic compact stars in energy–momentum squared gravity. We use Tolman [Formula: see text] solution and consider specific models of this theory to study the viable features of SAX J1808.4-3658, 4U 1538-52 and Her X-1 stars. We explore the behavior of energy density, pressure components, anisotropic factor, energy conditions and equation of state parameter in the interior of considered stars. To check the stability of these stars, we examine the behavior of causality conditions, Herrera cracking approach and adiabatic index. It is found that all the required conditions are satisfied for the proposed models, thus the considered stars are viable as well as stable in this modified theory.
CANDIDA PANOPHTHALMITIS WITH IATROGENIC HYPERADRENOCORTICISM IN TWO DOGS
Authors: Yang Shu-Fang , Yang Heng-Leng , Wang Peng-Chen , Liang Sao-Ling
Published: December 2022

Two adult poodles were referred for severe corneal ulcers in both eyes (oculi uterque [OU]) for 1.5 months, and swollen eyelids for approximately 1 week. Ophthalmic examination revealed diffuse corneal edema with grayish deposit and ulcer, uveitis, glaucoma, grayish deposit and necrosis on the third eyelid and conjunctiva, eyelids necrosis, eyelid-eyeball adhesions, and blindness. Cytological examination of the conjunctiva and cornea revealed neutrophilic inflammation, and a bacterial culture revealed Staphylococcus aureus. An adrenocorticotropic hormone stimulation test was performed, strongly indicating iatrogenic hyperadrenocorticism. No improvement was observed after 2 weeks of antibiotic treatment. Fungal cultures from the cornea and conjunctiva were positive for Candida spp. Specific antifungal treatment included topical 5% natamycin eye drops (OU six times daily) and oral itraconazole (5[Formula: see text]mg/kg q12[Formula: see text]h). The grayish deposits of the conjunctiva and cornea were sloughed off, thus facilitating the healing of corneal and eyelids ulcers, over the next 3–4 weeks. Phthisis bulbi and eyelid-eyeball adhesions developed in both dogs after 6 months of follow-up. Based on the fungal isolation by culture, clinical signs, and response to antifungal treatment, Candida spp. panophthalmitis was diagnosed. Fungi should be considered a potential organism in panophthalmitis, especially with a medical history of steroids and antibiotic use. This case report demonstrates the grayish deposits of the cornea, conjunctiva, and third eyelid as possible characteristics of Candida infection in the dogs. To our knowledge, this is the first report of Candida panophthalmitis with iatrogenic hyperadrenocorticism in dogs.
A short note on hyperenergetic Cayley graphs
Authors: Wu Yushi , Liu Weijun , Lu Lu
Published: December 2022

A graph [Formula: see text] on [Formula: see text] vertices is called a hyperenergetic graph if [Formula: see text] where [Formula: see text] is the energy of [Formula: see text]. In this paper, we consider hyperenergetic Cayley graphs. In detail, for any abelian group [Formula: see text], we construct a class of Cayley graphs over [Formula: see text], in which almost all are hyperenergetic. Furthermore, we also construct such a class of Cayley graphs over the dihedral group.
Inverse fair domination in the join and corona of graphs
Authors: Enriquez Enrico L.
Published: December 2022

Let [Formula: see text] be a connected simple graph. A dominating subset [Formula: see text] of [Formula: see text] is a fair dominating set of [Formula: see text] if all the vertices not in [Formula: see text] are dominated by the same number of vertices from [Formula: see text]. Let [Formula: see text] be a minimum fair dominating set of [Formula: see text]. A fair dominating set [Formula: see text] is called an inverse fair dominating set of [Formula: see text] with respect to [Formula: see text]. The inverse fair domination number of [Formula: see text] denoted by [Formula: see text] is the minimum cardinality of an inverse fair dominating set of [Formula: see text]. In this paper, we investigate the concept and give some important results. Further, we give the characterization of an inverse fair dominating set in the join and corona of two graphs.
Green Synthesis, Characterization, and Acoustical Analysis of Copper Quantum Dots (Cu QDs) Using Leaf Extract of Mangifera indica Plant
Authors: Behera Shreelata , Shubhadarshinee Lipsa , Mohapatra Pooja , Jali Bigyan Ranjan , Mohapatra Priyaranjan , Barick Aruna Kumar
Published: December 2022

The copper quantum dots (Cu QDs) are successfully green synthesized from copper sulfate (CuSO[Formula: see text] as precursor material using plant leaf extracts of Mangifera indica. The mangiferin as a natural glucosylxanthone present in leaf extract of M. indica acquires antioxidant, antimicrobial, antidiabetic, antiallergic, anticancer, hypocholesterolemic, and immunomodulatory activity, which acts as an effective stabilizing and reducing agent for conversion of the copper ion (Cu[Formula: see text] into the Cu QDs in aqueous medium. The green synthesized Cu QDs are characterized using ultraviolet–visible (UV–Vis) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, fluorescence spectroscopy, dynamic light scattering instrumental techniques, which confirm the successful synthesis and photoluminescence (PL) behavior of the Cu QDs. The ultrasonic investigation was carried out to find out the variation of ultrasonic velocity and density with concentration of Cu QDs in aqueous leaf extracts of M. indica plant as well as to calculate the dependency of acoustical parameter, namely adiabatic compressibility, acoustic impedance, and intermolecular free length on concentrations. The synthesized Cu QDs are biocompatible that can be a potential candidate for various in vivo and in vitro applications such as antioxidant, antimicrobial, anticancer, biosensor, bioimaging, and biocatalysis fields.
Review Article on the Relationship between Spondyloarthritis and Osteoporosis
Authors: Kwok Wing Sum , Chung Ho Yin
Published: December 2022

Introduction: To investigate the relationship between spondyloarthritis (SpA) and osteoporosis including any association or prediction, and hence suggesting a plan of screening and management for osteoporosis in SpA.

Methods: 168 and 538 research articles with keywords “osteoporosis” and “spondyloarthritis” or “ankylosing spondylitis” conducted between 1990 and 2021 were collected in Medline and PubMed, respectively. Focused review was conducted in 34 articles.

Results: Osteoporosis is a common comorbidity in both ankylosing spondylitis and spondyloarthropathy as suggested by multiple studies across different countries, with a reduction in bone mineral density (BMD) and altered bone microarchitecture in vertebrae and cortical bone of proximal femur, leading to an increased risk of vertebral fractures and sarcopenia. Associated factors include male sex, advanced age, long disease duration, high serum erythrocyte sedimentation rate (ESR), decreased femoral and lateral lumbar BMD, and high radiological indices. It is likely to be related to chronic systemic inflammation and immobility. Serum uric acid level, certain genes and antibodies may also contribute to the pathology. The likelihood of osteoporosis in SpA can be evaluated by trabecular bone score, which are negatively correlated with serum levels of ESR and C-reactive protein (CRP). Alendronate with adequate dietary intake of calcium and vitamin D is the recommended management.

Conclusion: The prevalence of osteoporosis is higher in patients with SpA due to the chronic presence of pro-inflammatory cytokines, functional impairment, and steroid therapy. With the help of inflammatory markers, imaging and radiological indices, the risk of osteoporosis, and vertebral fractures can be predicted. The management plan should be modified to include prevention and treatment of osteoporosis.
Preparation and Characterization of Gd2O3: Er3+ Nanosphere Particles Combinated with Chitosan Gd2O3: Er3+@CS
Authors: Chau Pham Thi Minh , Thai Dang Van , Ha Vu Thi Thai , Loc Dinh Xuan , Nguyen Tien Dai , Van Bui Hong , Anh Tran Kim
Published: December 2022

Nanospherical upconversion luminescence particles (UCLPs) Gd2O3:Er3+ and Gd2O3:Er3+@ chitosan (CS) were prepared by step-by-step precipitation and calcination of the available nitrate rare Earth sales and chitosan. The morphology and composition of as-prepared samples were characterized by field emission electron spectroscopy (FESEM) and Fourier transform infrared (FT-IR) spectroscopy. The synthesized UCLPs were non-agglomerate spheres in uniform nanoscale. The quantitative amount of chitosan was well coated with the gain surface of the UCLPs Gd2O3:Er3+ to obtain Gd2O3:Er3+@CS nanocomposite. The down-conversion luminescent intensity of Gd2O3:Er3+ NSP is lower than Gd2O3:Er3+@CS NSP samples, but luminescent characterizations were non-change. The photoluminescence (PL) of the green emission range of all UCLPs samples with chitosan-coated and -uncoated took the leading position. By using a diode laser excitation with 975 nm of wavelength, the detected intensity of red emission is more remarkably detected than green emissions. The two-photon mechanism for both green and red emissions of nanophosphor was observed. As a result, these might be promising opportunities to conjugate with various bio subjects that could be used in medical applications.
Kartogenin Improves Osteogenesis of Bone Marrow Mesenchymal Stem Cells via Autophagy
Authors: Yan Huichun , Yu Tingting , Li Jing , Zhang Ting , Li Qian , Zhou Yanheng , Liu Dawei
Published: December 2022

Kartogenin (KGN), a novel small-molecule compound, has been considered a promising chondrogenic promoter in cartilage regeneration. However, whether KGN also participates in osteogenesis and bone regeneration remains unclear. This research was designed to explore the roles of KGN on osteogenic differentiation in bone marrow mesenchymal stem cells (BMMSCs) as well as determine the possible mechanism of osteogenesis. We revealed that KGN enhanced the osteogenic differentiation capacity of BMMSCs without affecting cell proliferation, during which autophagic activities and the expression of autophagy-related genes were promoted. Moreover, KGN upregulated the phosphorylation level of the Smad1/5/9 signaling, and inhibition and activation of Smad signaling were also applied to validate the involvement of Smad in BMMSCs during KGN treatment. In summary, this study shows that KGN promotes osteogenic differentiation of BMMSCs through enhancing autophagic levels and upregulating Smad1/5/9 signaling mechanically.
Influence of Public Bus Driver’s Driving Behaviors on Passenger Fall Incidents: An Analysis Using Digital Tachograph Data
Authors: Jeong Harim , Park Wonil , Lee Jaeyoung , Park Sungho , Yun Ilsoo
Published: December 2022

Owing to the low occurrence of public transport accidents, most existing studies have focused on improving the traffic safety of passenger cars. However, traffic accidents related to public transport should also be investigated for the safety of public transport users, particularly the vulnerable ones. This study analyzed the behavioral factors affecting passenger fall incidents on buses to enhance the safety of public bus passengers. This study considered potential influential factors, such as acceleration, deceleration, braking, and steering maneuvers, calculated using data from digital tachographs installed on the buses. Negative binomial and Poisson lognormal regression models were built using the Bayesian method. The two models yielded similar results. In all cases, deceleration-related behavioral factors (abrupt deceleration and abrupt stop) significantly influenced passenger fall incidents. The findings from this study are significant for establishing effective strategies to reduce fall incidents by providing safety education to bus drivers.
Investigation of Structure and Optical Properties for Copper Oxide Thin Films on Plastic Substrate by Helicon Plasma DC Magnetron Sputtering Technique
Authors: Alhattab Anmar , Alhattab Haider , Takano Ichiro
Published: December 2022

As we move towards a decarbonized society, transparent solar cells have recently become an important means of increasing power generation in familiar locations. Copper oxide has been attracting attention as a candidate material for the production of transparent solar cells. In order to further expand the range of applications, it is believed that it will be necessary to develop flexible, transparent plastic substrates. For the purpose of optical applications, copper oxide thin films with CuO, Cu2O, or both phases were fabricated on highly transparent plastics such as poly-methyl methacrylate (PMMA) and polycarbonate (PC), as well as on a glass substrate as a comparable sample. The helicon plasma DC magnetron sputtering method was used to fabricate thin films at a low deposition temperature due to the low heat resistance of plastic substrates. In addition, the helicon plasma DC magnetron sputtering method is capable of depositing films at low vacuum pressure, which enables the preparation of thin films with high crystallinity. The structure, surface shape, and optical properties of fabricated films were investigated using X-ray diffraction (XRD), a laser microscope, and a UV-Vis spectrophotometer, respectively. In this study, the formation of copper oxide thin films on plastic substrates at low temperatures has been verified, as have the crystal structure and optical properties, which is considered a rare study in this field.
Enhancing the Power of CNN Using Data Augmentation Techniques for Odia Handwritten Character Recognition
Authors: Das Mamatarani , Panda Mrutyunjaya , Dash Shreela
Published: December 2022

The performance of any machine learning model largely depends on the type of input data provided. The higher the volume and variety of the data, the better the machine learning models get trained, thereby producing more accurate results. However, it is a challenging task to get high volume of data in some cases containing enough variety. Handwritten character recognition for Odia language is one of them. NITROHCS v1.0 for handwritten Odia characters and the ISI image database for handwritten Odia numerals are the standard Odia language datasets available for the research community. This paper shows the performance of five different machine learning models that uses a convolutional neural network to identify handwritten characters in response to handwritten datasets that are manipulated and expanded using several augmentation techniques to create variation and increase the volume of the data in the given dataset. These models, with the augmentation techniques discussed in the paper, even lead to a further increase in accuracy by approximately 1% across the models. The claims are supported by the results from the experiments done on the proposed convolutional neural network models on standard available Odia character and numeral data set.
A Case of Corneal Melting in a Patient with HER2-Positive Breast Cancer
Authors: Peeters Deborah , Vereecken Melissa , Denys Hannelore , Roels Dimitri
Published: December 2022

Trastuzumab is the cornerstone treatment for HER2-positive breast cancer. While ocular side effects are more commonly described after the use of the antibody-drug conjugate ado-trastuzumab emtansine, we here describe corneal melting in a 79-year-old patient after three cycles of trastuzumab monotherapy. Signs and symptoms persisted with subsequent trastuzumab cycles. The patient showed improvement after treatment with intense lubrication, topical antibiotics, and topical steroids. After tapering of steroids, there was recurrence of epitheliopathy after subsequent trastuzumab treatment, which subsided upon restarting topical steroids. Finally, the patient was kept on a low-dose topical steroid regimen which prevented further epitheliopathy during the next trastuzumab cycles.
Improving patient knowledge on rational use of antibiotics using educational videos
Authors: Ghozali Muhammad Thesa , Hidayaturrohim Bagus , Dinah Amalia Islamy Izdihar
Published: December 2022

Providing proper knowledge on the rational use of antibiotics plays a role in the success of the treatment process of infectious diseases and the prevention of antibiotic resistance. In this modern digital era, healthcare professionals can utilize video as a medium for patient education. This study was meant to determine the efficacy of a video-based educational intervention in improving the levels of knowledge on the rational use of antibiotics. The study used a quasi-experimental pretest-posttest with a control group design and involved 140 participants. Data collection utilized a questionnaire that was carried out from July to December 2021 at the Special Region of Yogyakarta, Indonesia. The intervention was conducted for four weeks with a lecture and group discussion using video as educational media. The results of this study found that educational videos significantly improved the levels of knowledge on the rational use of antibiotics, known by an increase in the mean value of the treatment group by 2.590 with a p-value of 0.001, and a difference in the mean value of posttest scores of both groups by 1.900 with a p-value of 0.001. It could be concluded that video could be utilized as an effective medium of patient education, notably the use of antibiotics.
Assessing six decades of rabies in the Philippines
Authors: Morilla Ralf Benjo Goder , Cabanlit Kathleen Laum , Luga Angel Mae Frias , Demayo Chin-Chin Jimenea , Sidic Jamerah Baniaga , Demayo Cesar Guinanao
Published: December 2022

Despite initiatives to address the disease, rabies remains a public health threat in the Philippines. To determine the trend of rabies infections in the country and provide possible interventions to reduce or eliminate deaths of the affected, we evaluated rabies morbidity and mortality statistics over sixty years. Over the last six decades, rabies mortality rates in the Philippines have steadily decreased. The Philippines' rabies sex-specific mortality rate trend from 1960 to 2019 showed that males account for higher rabies mortality than females. People aged 70 and up have the highest mortality rate, while children under the age of 1 have the lowest. The region with the highest mortality rate in the Philippines is region II (Cagayan Valley), with 39.5. The region with the highest morbidity rate is XI (Davao region), with 148.7. The correlation value was 0.197, indicating a weak correlation between regional morbidity and mortality rates in the Philippines over the years. Hence, those who have contracted rabies are less likely to die over time. Comprehensive control measures by both the national and local government units should be strengthened to eliminate rabies in the Philippines within the next few years.
Control of industrial major accident hazard regulation in Malaysia: second decade in examination
Authors: Mat Rashid Rasyimawati , Radin Umar Radin Zaid
Published: December 2022

The Control of Industrial Major Accident Hazards (CIMAH) regulations was introduced in 1996 to regulate workplaces with hazardous chemicals in their facilities. The Regulations provide a minimum standard to ensure precautionary measures related to major hazard risks are taken. Although the Regulations have been enforced for more than two decades in Malaysia, there have been limited efforts to review related information, trends and data since its inception. The study aimed to provide an overview of the position of CIMAH regulations after two decades of being enacted in Malaysia. Data were extracted from the published and unpublished reports and documentations by Department of Occupational Safety and Health of Malaysia (DOSH), as well as available publications from literary journals. Analysis of the contents revealed three categories of data: i) CIMAH regulations’ administrative governance changes; ii) major hazard industries–categorization and registration trends; and iii) CIMAH regulations’ punitive activities. The findings provide an overview of relevant trends and data related to CIMAH regulations in the past two decades, and may provide stakeholders such as policymakers, practitioners, and researchers a groundwork for improvement initiatives.
Recommendation of precision medicine application in Indonesia from multiple perspective: a review
Authors: Hisan Urfa Khairatun , Amri Muhammad Miftahul
Published: December 2022

Recently, precision medicine has gained much attention. Precision medicine helps reduce trial-and-error prescribing and minimize adverse drug reactions while improving the drug's effectiveness. Precision medicine is a medical method that seeks to maximize healthcare quality by tailoring the healthcare process to each patient's unique characteristics. In the era of rapid technological growth and data explosion, precision medicine's development has become very promising. Development of techniques for obtaining medical data; significant reductions in the cost of bio sequencing; massive development of computing tools, storage systems, and wireless communication systems; as well as the development of data analysis techniques based on artificial intelligence have all become significant driving forces in the advancement of precision medicine. In this manuscript, we summarized previous studies on precision medicine development. In addition, we discussed the opportunities and potential challenges of precision medicine development, particularly in Indonesia. Despite its promising potential, many challenges remain to be overcome to develop precision medicine. Good regulations for patient data ownership and clinical data-sharing, followed by sufficient data infrastructure and human resource capabilities, are the most critical factors in ensuring success in precision medicine. Moreover, guaranteeing data safety, patient privacy, and genome fairness are other issues that must be addressed.
Prevalence of COVID-19 in flood relief centre
Authors: Kumareswaran Suriya , Muhadi Siti Umairah , Sathasivam Jeyanthini , Murali Sundram Bala
Published: December 2022

Since the beginning of 2020, people all around the world have been struggling with the impacts of the COVID-19 pandemic. Concurrently, major flooding and a pandemic have struck numerous regions of the world. As a result, relief centres for flood victims have been established in the affected regions. There is a risk of COVID-19 infection spreading among flood victims and workers at flood relief centres due to the enormous number of flood victims. This study focused on the Johor, Malaysia flood catastrophe. From the 1st to the 16th of January 2022, a cross-sectional study was conducted in johor flood relief centres using secondary data from E notification and COVID-19-line listing. 1,531 flood victims were examined for COVID-19 and Rapid antigen testing was performed. 711 victims were asymptomatic, whereas 820 victims were symptomatic. Six patients were identified as positive. During audits of multiple evacuation centres, few concerns were found. There was no sufficient ventilation, there was no distribution of face masks to victims, and there were no daily health checks. COVID-19 preventive measures in all evacuation centres need to be practiced and given attention by all occupants and agencies.
The impact of the basic dose of the COVID-19 vaccine and the number of COVID-19 patients on Google searches for vaccines
Authors: Sandyawan Ignatius , Kurniawan Robert , Trismanjaya Hulu Victor , Judea Samosir Frans
Published: December 2022

Indonesia has distributed the COVID-19 vaccinations to its people starting from January 2021 based on certain priorities to deal with COVID-19 pandemic. News of deaths after the COVID-19 vaccination has made some people hesitate to get vaccinated. This study aims to depict the pattern and determinant of public interest in COVID-19 vaccine information using Google Trends data. The pattern can be used as a suggestion to the government to conduct a campaign on the COVID-19 vaccine. Several topics related to the COVID-19 vaccine were collected from Google Trends and then clustered by the province using K-Means. By total within sum of square, best number of clusters is two. Then, a logistic regression analysis was done with cluster as response variable to find out what factors made people interested in the COVID-19 vaccine topic. As a result, percentage of people who received the first dose of the COVID-19 vaccine and the rate of COVID-19 patients who were treated had influenced public interest in the COVID-19 vaccine. Hence, the campaign must be transparent so that the public can see both the good and bad effects of vaccination. It will help to reduce the number of people dying after receiving vaccinations.
Service quality and patient satisfaction with private health care services in Albania
Authors: Kalaja Rezarta , Kurti Sllavka , Myshketa Redi
Published: December 2022

Hospital service in Albania is facing difficult challenges, always trying to evolve and reform not only related to the high demand for improvement on the available infrastructure and technology, but also due to the private hospital services competition in keeping medical staff and patients with the obligation to ensure quality care, as a fundamental human rights requirement. The purpose of this study is to make an overall assessment regarding the quality of health care in the private sector in Albania and patient satisfaction related to this service. This paper also aims to determine the main factors that play a role in patient satisfaction, and their level of importance, to provide appropriate recommendations that will support the improvement of the quality of service and increasing patient satisfaction in this sector. The instrument used for quality assessment is SERVQUAL, with five main dimensions selected (responsiveness, reliability, safety, tangibles and empathy). Data processed for 400 interviewed patients shows the correlation of patient satisfaction with only four of the elements considered. Hence, the results obtained will back applicable recommendations for developing quality and increasing patient satisfaction.
Serious “human papillomavirus vaccine” game for Malaysian adolescents: development and preliminary study
Authors: Mohd Hasni Nur Hazreen , Asyraf Mior Azalian Akmal , Asmawaty Abdul Kadir Tuty , Hisham Mohd Adib Mohd Azrul
Published: December 2022

In Malaysia, cervical cancer is the top three most common cancer among women. Vaccination and screening are mandatory for the prevention of the disease. Therefore, we aimed to develop a serious game for Malaysian adolescents, the "HPV Vaccine” game objectively to transmit knowledge about human papillomavirus (HPV), create awareness of cervical cancer, and promote HPV vaccine uptake. This game development targeted teenagers aged 10 to 17 years. We expect to complete three levels and answer all 15 questions. Inclusion criteria were Malaysian citizens, who owned a computer with connectivity to the game. We excluded those with a physical disability. This game was the first edutainment on Human papillomavirus, cervical cancer, and the HPV vaccine. We conducted a preliminary study, cross-sectionally, purposive sampling method. We recruited 20 participants; only 16 participants consented and completed the study. All participants enjoyed the wireframes of the game, with an average of 12 to 15 minutes to complete the game. Results demonstrate that participants were highly engaged with the “HPV Vaccine” game. We believe this game, is a forward technology that will beneficial for adolescents' adherence to HPV vaccination. In the future, we suggest an observational study to assess players' perspectives on this game.
Editorial
Authors: Silva Márcia Regina da
Published: December 2022

Editorial:

InCID: Revista de Ciência da informação e Documentação, Ribeirão Preto, v. 13, n. 2, set. 2022/fev. 2023.
Divulgação da produção científica acadêmica por meio de vídeo: uma proposta de serviço para bibliotecas universitárias
Authors: Buss Clarice , Juliani Jordan Paulesky , Sant'Anna Juliana Silva , Sombrio Liz Kelli de Amorim
Published: December 2022

Este artigo aborda a concepção de um serviço de informação baseado em tecnologia cujo objetivo é ampliar a divulgação de produções científicas da Universidade do Estado de Santa Catarina. Para isso, foi desenvolvido um portal de vídeos acadêmicos a ser mantido pela biblioteca central da universidade. A tecnologia utilizada foi o ClipBucket, na sua versão gratuita, disponível na internet. Quanto aos aspectos metodológicos, esta é uma pesquisa aplicada, com caráter exploratório, que utiliza procedimentos técnicos de pesquisa-ação e pesquisa experimental, permitindo o desenvolvimento de um experimento para demonstrar como os trabalhos acadêmicos podem ser divulgados e compartilhados de forma mais dinâmica. Como resultado, obteve-se um protótipo de plataforma de divulgação científica, a qual ainda não foi colocada em validação. O portal de vídeos é uma ideia inovadora, simples e viável de ser implementada que permite que o conhecimento produzido pela comunidade acadêmica ultrapasse as barreiras da universidade.
Uso do campo informacional na interpretação de fluxos de dados: um estudo do processo de apuração do ICMS nas atividades agropecuárias
Authors: Moreira Fábio Mosso , Felipin Marcelo Luis Saran , Lourenzani Wagner Luiz , Sant'Ana Ricardo César Gonçalves
Published: December 2022

Este artigo apresenta resultados de uma pesquisa que investiga o fluxo de dados gerados no processo de apuração do ICMS advindo da produção agropecuária municipal. Tais repasses são fundamentais para o financiamento de políticas públicas e são balizados por indicadores calculados a partir dos dados gerados na atividade. Neste sentido, é importante instrumentalizar a interpretação do fluxo de dados que ocorre entre os atores envolvidos, uma vez que esta informação implica na qualidade do cálculo dos indicadores e influenciam na transferência dos recursos para os municípios aplicarem na execução das políticas públicas que dependem desta fonte. Neste contexto, o objetivo consiste em estudar, a partir da perspectiva da Ciência da Informação, a aplicabilidade do campo informacional na instrumentalização da análise de fluxos de dados resultantes do processo de apuração do ICMS na atividade agropecuária do Estado de São Paulo. Apresenta-se uma sistematização do processo de apuração e a representação dos seus elementos na estrutura do campo informacional. Destaca-se, também, o papel dos atores envolvidos nos ciclos de vida dos dados existentes neste fluxo. Espera-se que estes resultados possam subsidiar melhorias nos fluxos dos dados, apoiando a tomada de decisão nas atividades dos servidores que atuam na inteligência fiscal dos municípios. O controle e acompanhamento mais eficiente desse fluxo pode propiciar ampliação no aporte de recursos para financiar a operacionalização de políticas públicas para o setor da agropecuária daquela localidade.
O problema da informação: considerações sobre a designação da área
Authors: Amorim Igor Soares
Published: December 2022

Bibliografia, biblioteconomia, documentação, organização do conhecimento, ciência da informação dentre outras disciplinas compartilham aspectos teóricos e práticos que tornam as fronteiras disciplinares imprecisas e dificultam a definição epistemológica de pesquisas. Para constatar essas imprecisões metodológicas, foi realizada uma análise semântica das definições de biblioteconomia, documentação e ciência da informação. A partir disso, foi discutida a noção de problema no contexto da ciência e refletido sobre o problema informacional. O problema informacional é considerado como elemento comum entre as diferentes disciplinas, que o abordam a partir de suas especificidades. Propõe-se a noção de Área de Informação como forma de se referir ao conjunto de conhecimentos relativos ao problema informacional sem, no entanto, conformar uma unidade. A Área de Informação revela-se agregadora e viabiliza um solo epistemológico para fundamentação de pesquisas sobre os tópicos comuns às diversas disciplinas.
Folia em revista: o teatro de Walter Pinto e a festa carnavalesca carioca
Authors: Marques Maximiliano Almeida Bastos da Costa
Published: December 2022

Este artigo aborda o diálogo entre o teatro de revista de Walter Pinto – produzido nos anos 1940 e 1950 – e o carnaval carioca por meio da revisão de literatura e de periódicos, bem como da análise de imagens e textos de peças do produtor. Inicialmente, caracteriza o esplendor visual e a dinâmica cultural de seus espetáculos, decorrentes da influência dos musicais realizados nos principais centros internacionais do entretenimento da época. Em seguida, examina de que forma o imaginário carnavalesco do período foi concebido em suas montagens de carnaval. Ao final, sugere que o padrão cênico feérico de suas produções inspirou mudanças na visualidade dos desfiles das escolas de samba, ressaltando diálogos e tensões entre diferentes expressões da cultura (FERREIRA, 2012; HALL, 2003; STOREY, 2015) na construção das estéticas “moulinrougiana” e “ziegfeldiana” das performances das agremiações carnavalescas.
Flora da Serra do Cipó, Minas Gerais: Myristicaceae
Authors: Lopes David Lucas Amorim , Correa Tabata Alves , Lírio Elton John de
Published: December 2022

Myristicaceae (Magnoliales) possui c. 20 gêneros e 500 espécies, com distribuição tropical e subtropical no globo. O presente estudo visa a elaboração do tratamento taxonômico da família no âmbito do projeto “Flora da Serra do Cipó, Minas Gerais”. Myristicaceae é representada na região por uma espécie, Virola bicuhyba, endêmica da Mata Atlântica. São apresentadas descrição morfológica, ilustrações e comentários para a espécie.
Flora da Serra do Cipó, Minas Gerais: Siparunaceae
Authors: Brunassi Gustavo Rebechi , Zavatin Danilo Alvarenga , Pauli Maria , Peixoto Ariane Luna , Lírio Elton John de
Published: December 2022

No presente trabalho é apresentado o estudo taxonômico de Siparunaceae como parte do projeto “Flora da Serra do Cipó, Minas Gerais, Brasil”. A família está representada na região por três espécies: Siparuna brasiliensis (Spreng.) A.DC., Siparuna guianensis Aubl. e Siparuna reginae (Tul.) A.DC. São apresentados descrições morfológicas, ilustrações e comentários para as espécies.
Flora da Serra do Cipó, Minas Gerais: Hydroleaceae
Authors: Zavatin Danilo Alvarenga , Almeida Roberto Baptista Pereira , Antar Guilherme Medeiros
Published: December 2022

O estudo taxonômico de Hydroleaceae é aqui apresentado como parte do projeto “Flora da Serra do Cipó, Minas Gerais, Brasil”. A família está representada na área por uma espécie: Hydrolea spinosa L., para a qual apresentamos uma descrição, ilustração, além de comentários sobre a distribuição geográfica, habitat e fenologia.