bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of Family Function on Mental Health Problems of College Students in China During COVID-19 Pandemic and Moderating Role of Coping Style: A Longitudinal Study
Authors: Liu Lili , Chen Jianbin , Liang Shunwei , Yang Wenwen , Peng Xiaodan , Cai Chengcheng , Huang Andi , Wang Xiayong , Zhao Jingbo
Published: October 2022

Background

During the COVID-19 pandemic, college students were required to stay at home and maintain social distancing the entire spring semester of 2020. There is little research on how family function influenced mental health problems and how coping styles moderated the relationship between family function and mental health problems among college students during their stay-at-home period.

Methods

We carried out four evaluations between February and October 2020 through an online survey. A total of 13,462 college students (age = 16–29 years) participated. Family function, coping styles, depression symptoms, and anxiety symptoms were studied. To evaluate the associations between variables, a generalized estimating equation was used.

Results

Findings indicate that the incidence rates of depression rose during stay-at-home period from 33.87%, 95% CI (29.88%, 38.10%) to 40.08% 95% CI (35.76%, 44.55%) after schools reopened, χ2 = 193.68, p < 0.001. The incidence rates of anxiety rose from 17.45%, 95% CI (14.59%, 20.73%) to 26.53%, 95% CI (16.94%, 23.67%) through the entire period, χ2 = 195.74, p < 0.001. The incidence rate of depression and anxiety for different family function groups varied at different time points, the interaction effect was significant (χ2 = 52.97, p < 0.001 and χ2 = 51.25, p < 0.001, respectively). The incidence rate of depression and anxiety for different family function groups with different coping styles also varied at different time points, the interaction effect was likewise significant (χ2 = 862.09, p < 0.001 and χ2 = 583.29, p < 0.001, respectively).

Conclusions

These findings shed light on how family function intersected with coping styles to influence the mental health problems of college students during and after the stay-at-home period of COVID-19. These findings highlight the importance of paying special attention to college students' family function and promoting appropriate coping strategies during and after COVID-19.
Analysis of the mineral resource base of gold mining in the Lena gold-bearing district and substantiation of the development directions of placer mining methods
Authors: Dorosh E. A. , Talgamer B. L.
Published: October 2022

Development of the gold mining industry is in the first place associated with an increase in the mineral resource base, development of promising deposits and improvement in the quality of raw materials. At the same time, experts have been noting a deterioration in the quality of alluvial gold reserves over the last years both in Russia as a whole and in Eastern Siberia in particular. Therefore, the purpose of this research is to analyze the dynamics of the mineral resource base of gold mining in the Lena gold-bearing area as well as to substantiate the development trends of the placer development technology. The assessment was given to the state of the mineral resource base of the gold mining industry of the Irkutsk region in the period from 2000 to 2021. A quantitative and qualitative characteristic of alluvial gold reserves was provided with identified key changes caused by placer mining over the past 20 years. Having indicated the deterioration dynamics in the quality of alluvial gold reserves, the authors specified its reasons for the period under analysis. In addition, a brief description of the main mining and engineering indicators of the large and medium-sized alluvial gold deposits worked out in recent years is given. The distribution structure of reserves in technogenic deposits is presented. The conclusions are formulated on the results of the research performed, relevant problems of modern placer gold mining are formulated and the prospects of placer mining in the Irkutsk region are assessed. The replenishing possibilities of the mineral resource base by involving technogenic reserves in the development are described.
Bioherms of the Bozhekhan uplift in the Cis-Baikal trough as a marginal barrier reef system of a Cambrian salt basin of the southern Siberian platform
Authors: Vakhromeev A. G. , Kornilova T. A. , Misurkeeva N. V. , Urenko R. S. , Stanevich A. M. , Stepanova N. I. , Pulyaevskiy M. S.
Published: October 2022

Modern forecast, exploration and development of hydrocarbon deposits within natural carbonate reservoirs of buried bioherm (reef) structures in the north of the Irkutsk region and the Sakha Republic (Yakutia) areas within the NepaBotuoba Anticline apply the most advanced technologies of 3D seismic exploration and geoelectric prospecting supplemented with a set of new interpretation approaches and analysis attributes contrasted against wide range of well logging data. The recent discoveries of hydrocarbon deposits in the northern reefs shoved the bioherms of the Irkutsk amphitheater in the shadow. The purpose of this research is geological study of biohermal carbonate formations of the Lower Cambrian age in the outcrops of the Bozhekhansky megaswell in the Baikal region. The choice of this object of study is due to the fact that the first oil and gas inflows were obtained from the wells of the Atovskaya, Osinskaya, Birkinskaya, Khristoforovskaya, Balykhtinskaya and Tuturskaya areas. Field geological routes and office processing of data on cuts and polished thin sections of sample surfaces were carried out including microscopic studies in the thin sections of samples and archival collections of cores from deep oil and gas prospecting wells. In 2021–2022, while prospecting in the south of the Irkutsk amphitheater, the authors explored stratified, nodular and columnar stromatolites found within the compound Bozhekhan megaswell of Cambrian carbonate outcroppings. Carbonate intraformational sedimentary breccias identified in the area under investigation feature a great variety in their fragment sizes and inclusions. The stromatolites’ structural features were studied by the cuts and polished thin sections of sample surfaces. Microphytolites were found in the thin sections and described. The authors also took advantage of the opportunity to study an archive collection of the thin sections of VendCambrian and Lower Cambrian carbonate strata from the Akhinskaya area’s wells at the Bozhekhan megaswell and from the Upper-Lena uplift to the north-west. The conducted study implies that Cambrian bioherm outcroppings of the Bozhekhan megaswell-type uplift within the Cis-Baikal trough are, in a sense, model geologic objects. The study of biologic and genetic varieties of Lower Cambrian phytolites, diagnostic features of the organogenic structures, their inner structure and formation processes of the reef ecosystem may provide a region-level prognostic key to the research of Cambrian sediment system in the south of the Siberian platform.
Visitors’ Interaction in an Experiential Designed Environment: A Case Study of a Multimedia Gallery
Authors: Elyna Amir Sharji  , Lim Yan Peng  , Peter Charles Woods  , Rose Linda Zainal Abidin
Published: October 2022

Currently, there has been a shift in the built environment in creating engaging exhibition spaces such as museums and galleries. This is a challenge nowadays as the creation of digital exhibition spaces depend largely on technological content and devices. Issues arise where visitors may not perceive the intended environment. It is seen that this sense of change needs further study on visitors’ perception and behaviour as users of the space. Experiential design deals with human interaction with the built environment. The objective of this study is to observe how visitors’ behaviour and interaction are influenced by the experiential design concept. A case study is conducted at a local gallery with selected visitor profile of young adults and adults with art and design background. The investigation is done based on the case study guideline, mapping out setting, and timing and tracking observation method to gauge visitors’ perception and action in a multimedia gallery. Eighty visitors were observed throughout the three-day exhibition from 9:00 a.m. to 5:00 p.m. Data collected answers the research question: how does the experiential design concept influence visitors’ behaviour and interaction in a multimedia gallery? The findings are beneficial to understand gallery visitors’ needs in achieving fulfilling interactive and engaging experience. From the observation done, it is identified that multimedia galleries incorporated with experiential design elements build meaningful experiences through the five senses, promotes a sense of place and well-being as well as the allowance for visitors to be more confident in approaching tools and devices that are unfamiliar to them. Curators, designers and artists will gain from this research in designing better interactive environment. The research limitation is the visitor age group which is the young adults and adults’ age group, as well as the single case study done.
Russian Practice of Promoting Food Delivery Services During the COVID-19 Pandemic
Authors: Zemskaia Y. N. , Zosimenko V. A. , Kuznetsova E. A. , Shiyan M. E.
Published: October 2022

The article discusses the Russian practice of promoting food delivery services during the COVID-19 pandemic. The study is based on the analysis of documents with elements of statistical and comparative analysis. The authors attempted to collect and systematize data on the use of communication tools by business enterprises during the lockdown period. The article presents data from various studies of the food retail market and the delivery of ready-made food in Russia. As a result of this study, the authors come to the following conclusions: (1) websites and applications of delivery services have become the main platforms of interacting with the audience, which in turn have become a separate object for promotion; (2) major market players managed to shape public opinion on delivery services, a new type of consumer behavior and people’s habits through communication. The study also showed an increase of GR in the communication activities of companies during the pandemic. One of the most popular communication tools that ensure the interaction between business and government has become regular offline and online meetings of entrepreneurs and heads of executive power at various levels.
Age-Related Socio-Psychological Features of Socialization
Authors: Tel'minova Kira
Published: October 2022

The article introduces a two-group classification of scientific publications on the age-related socio-psychological characteristics of people with special needs. The first group features the development conditions, while the second group focuses on the types of socio-psychological characteristics and the social groups they affect. The authors believe that adults with life-long disabilities and those who were registered as disabled at the age of majority have different socio-psychological profiles and socialization issues. An unstructured interview revealed that the socio-psychological characteristics of adults with life-long disabilities depended on the attitude to the disease shaped by their parents. As for people who acquired the status as adults, their attitude depended on the social skills they possessed before. They had a better social adaptability but a more difficult socialization later in life.
State and Legal Meaning of the Pan-Slavic Union in the Crisis of Modern Civilizational: N. Ya. Danilevsky's 200th Anniversary
Authors: Baburin Sergey
Published: October 2022

Abstract: The current civilizational crisis of ideology makes peoples join their efforts in search for adequate responses to the challenges of the time. The modern modeling of new state and legal forms of civilizational unity uses abstraction, analysis and synthesis, as well as specific historical and comparative legal approaches. Observation of political and legal processes makes it possible to hypothesize on the transformations of modern civilizational states. The present article features various possible forms of Slavic state unity. The authors used N. Ya. Danilevsky's scientific heritage to consider the theoretical and legal issues of pan-Slavism, as well as the civilizational contradictions between various Slavic peoples and between Russia and the West. The paper introduces three prospective levels of a Pan-Slavic unity. The first one presupposes Slavic self-identification with the preservation of the common folk spirit and the interpenetration of Slavic cultures. The second level involves an interstate confederation of Slavic states. The third level is a Slavic Federation of Russia, Belarus, and Serbia. The authors believe that a legal pan-Slavic unity is possible if it maintains different levels and forms. The existing European constitutional and state-building experience proves that unified political regimes and social systems are less important than an international legal mechanism for harmonizing pan-Slavic interests in Europe. This mechanism should be aimed at preserving the traditional closeness and mutual influence of Slavic cultures, art, everyday life, and mentality. This pan-Slavic interstate mechanism could coordinate the interests and stabilize the development of Europe. The Pan-Slavic union state is possible if individual Slavic states consolidate their civil and political will on their unification with Russia.
Analisis Penggunaan Zahir Accounting dengan Pendekatan Technology Acceptance Model
Authors:   Jurusan Akuntansi, Universitas Pembangunan Nasional Veteran Jakarta, Jalan RS. Fatmawati Raya, Pd. Labu, Kec. Cilandak, Kota Depok, Jawa Barat 12450, Putri Prasasti Herdiarti , Praptiningsih Praptiningsih ,   Jurusan Akuntansi, Universitas Pembangunan Nasional Veteran Jakarta, Jalan RS. Fatmawati Raya, Pd. Labu, Kec. Cilandak, Kota Depok, Jawa Barat 12450, Maulana Agus ,   Jurusan Akuntansi, Universitas Pembangunan Nasional Veteran Jakarta, Jalan RS. Fatmawati Raya, Pd. Labu, Kec. Cilandak, Kota Depok, Jawa Barat 12450
Published: October 2022

Penelitian ini merupakan penelitian kuantitatif yang bertujuan untuk mengetahui faktor-faktor penerimaan dan penggunaan Zahir Accounting. Pengambilan sampel menggunakan metode random sampling dengan jumlah sampel sebanyak 100 mahasiswa. Pengujian hipotesis dalam penelitian ini menggunakan Path Coefficients dengan melihat t-statistik dan Original Sample menggunakan program SmartPLS 3.0. Hasil pengujian tersebut menunjukkan bahwa (1) adanya pengaruh positif signifikan antara kemampuan menggunakan komputer terhadap persepsi kegunaan, (2) adanya pengaruh positif signifikan antara kemampuan menggunakan komputer terhadap persepsi kemudahan penggunaan, (3) adanya pengaruh positif tidak signifikan antara persepsi kemudahan penggunaan terhadap persepsi kegunaan, (4) adanya pengaruh positif signifikan antara persepsi kegunaan terhadap sikap pengguna, (5) adanya pengaruh positif signifikan antara persepsi kemudahan penggunaan terhadap sikap pengguna, (6) adanya pengaruh positif signifikan antara sikap pengguna terhadap minat perilaku, dan (7) adanya pengaruh positif signifikan antara minat perilaku terhadap penggunaan aktual. Penelitian ini memiiki keterbatasan yaitu, waktu peneliti untuk menyebarkan kuesioner terbatas, penyebaran kuisioner secara online, dan uji coba kuesioner tidak dilakukan. Penelitian ini diharapkan dapat membuka pikiran bahwa penggunaan teknologi sangat penting di era saat ini dimana transaksi bisnis yang kian hari makin rumit.
Pengungkapan Sustainability Report: Konsentrasi Kepemilikan dan Kepemilikan Institusional
Authors:   Universitas Pembangunan Nasional Veteran Jakarta, Jl. RS. Fatmawati Raya, Pd. Labu, Kec. Cilandak, Kota Depok, Daerah Khusus Ibukota Jakarta 12450, Sidiq Fais Muta'as , Surbakti Lidya Primta ,   Universitas Pembangunan Nasional Veteran Jakarta, Jl. RS. Fatmawati Raya, Pd. Labu, Kec. Cilandak, Kota Depok, Daerah Khusus Ibukota Jakarta 12450, Sari Retna ,   Universitas Pembangunan Nasional Veteran Jakarta, Jl. RS. Fatmawati Raya, Pd. Labu, Kec. Cilandak, Kota Depok, Daerah Khusus Ibukota Jakarta 12450
Published: October 2022

Penelitian ini merupakan jenis penelitian kuantitatif yang bertujuan untuk mengetahui pengaruh konsentrasi kepemilikan dan kepemilikan institusional terhadap pengungkapan sustainability report. Pengungkapan sustainability report diukur dengan GRI G4 dan GRI Standards. Sampel penelitian ini berjumlah 39 perusahaan non keuangan yang terdaftar di Bursa Efek Indonesia (BEI) periode 2017-2019. Regresi data panel digunakan untuk teknik analisis data dan hasil penelitian ini mengungkapkan bahwa konsentrasi kepemilikan berpengaruh signifikan dan positif terhadap pengungkapan sustainability report dan hasil lain dari penelitian ini semakin tingginya kepemilikan intitusional maka pengungkapan sustainability report perusahaan akan semakin rendah . Dengan hasil penelitian ini diharapkan otoritas jasa keuangan (OJK) dapat mempertimbangkan kebijakan tentang persentase kepemilikan intitusional terutama untuk perusahaan yang listed di BEI dikarenakan ditemukan hasil dari penelitian ini bahwa perusahaan yang memiliki kepemilikan institusional yang tinggi akan melakukan penurunan pengungkapan Sustainability Report.
Legal Awareness of Special Subjects as a Determinant of Their Legal Discretion
Authors:   Penza State University, Sumenkov S. Yu.
Published: October 2022

The article examines the interconnection between legal awareness and legal discretion of the special subject. The author notes the particular role of that type of the special subject as a subject of law enforcement is noted. It is these subjects who exercise the powers of power of public authorities, directly applying the norms of law. The author points out some contradiction between the objectively existing diversity of social relations and the reference nature of law. In this aspect, the author pays considerable attention to the norms of a dispositive nature indicating the framework limits of the action of the law enforcement officer. This kind of a norm is initially endowed with such a quality as legal uncertainty that determines the practical significance of legal discretion. The article reveals the essence of law enforcement discretion, its role in the implementation of legal norms and individual legal regulation. The article covers the algorithms for making law enforcement decisions that are taken as a result of discretion as a special kind of thought activity of a special subject. The obvious dependence of the discretion of the law enforcement official on sense of justice of the last is emphasized. The main role is played by professional legal consciousness, consisting of various components of legal psychology and legal ideology. Practical examples prove the need for law enforcement discretion, the absence of which entails a gap in legal regulation. At the same time, the author draws the attention to the possibility of abuse of the right of both the consequence of the defective legal norms and the legal awareness of the subject of law enforcement. Attention is paid to the need for constant work both on improving legal prescriptions that allow for the possibility of law enforcement discretion and a positive impact on the legal consciousness of the subject of law enforcement.
Preemptive Rights in the System of Legal Advantages: Aspects of the Ratio
Authors:   Balakovo branch of the Saratov State Law Academy, Dergunov A.A.
Published: October 2022

he article analyses such an ambiguous legislative category as «preemptive right». The author of the article remarks that preemptive right is included in the system of legal advantages because it represents the opportunity to receive benefits that is legally fixed by the state. The author, taking a doctrinal system of legal advantages as an example, compares it with the elements that build this system. The author analyses the comparison of preemptive right with the privilege, the benefit, the immunity and the special legal procedure. The article emphasizes that the first three kinds of legal advantages serve as exemptions to this rule. Preemptive right and the special legal procedure, in their turns, are not exemptions from the rule. Rather they represent special rules that serve as addition to the main ones. Besides, the author expresses disagreement with the point of view that denies the autonomy of preemptive rule. According to this point, preemptive right is viewed as another kind of special legal procedure. The author emphasizes the qualities that are intrinsic to preemptive right and that allow to differentiate it from the special legal procedure and from its subtype – the special order. The article by purpose mentions numerous examples from the existing legislation. They illustrate the position of the author with respect to the place and the role of preemptive right in the system of legal advantages.
Experience of Legislative Regulation of Extreme Necessity: Compfrftive Analysis.
Authors:   Baikal State University, Parkhomenko S.V. , Zhigzhitova B.B. ,   Ttrans-Baikal regional court
Published: October 2022

The article highlights the results of the analysis of modern foreign legislative regulation of extreme necessity in the system of circumstances that exclude criminality of the act, fundamental concepts and international practice of resolving the situations connected to clash of interests in protected social relations and evaluation of legal consequences of the situations of the same kind. Using the method of comparative analysis that is expressed in comparing particular features and qualities that are intrinsic to the researched institutions with its domestic specifics led to reaching of the following goal: holistic view was formed in researching of special features of the viewed legal phenomenon. The issues of domestic practice of building of the norm of the extreme necessity were analyzed and successfully applied. The mentioned imperfections of foreign regulatory acts in regulation of extreme necessity allows preventing ungrounded implementation of norms of foreign legislature. They also allows preventing building of wrong practice of legislative regulation of norms in the sphere implementation of the domestic criminal law policy to ensure the protection of individual and collective goods, the legitimate interests of society and the state. The author of the article comprehends the attitude to the creature, legal content and the purpose of the institute of extreme necessity. The author also distinguishes possible promising directions for the development of Chapter 8 of the Criminal Law of the Russian Federation.
Impacts of dike systems on hydrological regime in Vietnamese Mekong Delta
Authors: Xuan Nguyen Van , Giang Nguyen Ngoc Long , Ty Tran Van , Kumar Pankaj , Downes Nigel K. , Nam Nguyen Dinh Giang , Ngan Nguyen Vo Chau , Thinh Lam Van , Duy Dinh Van , Avtar Ram , Thu Minh Huynh Vuong
Published: October 2022

This paper examines the impact of the dike systems on river flows in the Vietnamese Mekong Delta (VMD). The study combined a hydrological change index method and the Mann–Kendall test to assess the temporal dynamics of both discharge and water levels along the main rivers of the VMD. Results highlight that the system of rivers and canals helps facilitate waterway traffic and drainage during the flood season. However, the low elevation of the delta has created conditions suitable for saline water to increasingly penetrate upstream during the dry season. Observed changes in the hydrological indicators at the upstream stations of Tan Chau (Mekong River) and Chau Doc (Bassac River) are not only due to the dike system but also upstream alterations to the flow regime. More research is needed to consider the various drivers of flow-regime change associated with natural and human activities both inside and outside of the study area.
DPP-Cu2+ Complexes Gated Mesoporous Silica Nanoparticles For pH
and Redox Dual Stimuli-Responsive Drug Delivery
Authors: Chen Wei , Ma Mingyang , Lai Qingteng , Zhang Yanke , Liu Zhengchun
Published: October 2022

Objective:

A simple pH and redox dual stimuli-responsive diketopyrrolopyrrole (DPP)-Cu2+ complexes gated mesoporous silica nanoparticles (MSN) were prepared for precise drug delivery and controlled drug release.

Methods:

MSN was prepared by sol-gel method and then laminated. Carboxylic acid (CA)-Pyrrolo[3,4-c] pyrrole-1,4-dione, 2,5-dihydro-3,6-di-2-pyridinyl (PyDPP) was grafted onto the surface of amino-functionalized MSN (MSN-NH2) through a simple amide reaction and then complexed with Cu2+ to form gated molecules after doxorubicin (DOX) loading.

Results:

Scanning electron microscopy (SEM), transmission electron microscopy
(TEM), and Low-angle X-ray diffraction (XRD) showed that MSN with uniform particle
size (100 nm) and porous structure was successfully prepared. The prepared MSN, MSN-
NH2, and MSN-DPP were fully characterized by Zeta potential, Fourier transforms infrared
spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS) and nitrogen adsorption-
desorption. High DOX-loading capacity (18.22%) and encapsulation efficiency
(89.16%) were achieved by optimizing the mass ratio of MSN to DOX. Release studies
showed that the gated molecules of our designed DPP-Cu2+ complexes had a good blocking
effect under physiological conditions (the cumulative release rate of drugs within 24
hours was only 4.18%) and responded well to the pH and redox glutathione (GSH) dual
stimuli. In vitro cytotoxicity assay showed that MSN-DPP-Cu2+ had good biocompatibility
in both Hep G2 cells and L02 cells (the relative cell viability of both cells within 48
hours was above 97%), and the MSN-DPP-Cu2+@DOX could be triggered for efficient
drug release in Hep G2 cells.

Conclusion:

The MSN-DPP-Cu2+ described in this research may be a good delivery system for the controlled release of antitumor drugs and can provide a potential possibility for clinical application in the future.
Prognostic Significance of ZP3 in Hepatocellular Carcinoma
Authors: Bi Yuanjian , Jin Song , Tang Guorong , Pan Dingquan , Song Xin , Zhu Xiaonian , Tan Shengkui
Published: October 2022

Objective:

The study aims to explore the prognostic significance of zona pellucida glycoprotein 3 (ZP3) in hepatocellular carcinoma (HCC) tissues.

Methods:

The expression of ZP3 protein in HCC tissues was detected by immunohistochemistry (IHC) to study its effects on the clinicopathological characteristics and prognosis of HCC patients. The Cancer Genome Atlas (TCGA) database was used to confirm the expression of ZP3 in HCC tissues and Gene set enrichment analysis (GSEA) was performed to obtain potential ZP3-related pathways in HCC.

Results:

IHC detection found that ZP3 had a high expression in HCC tissues and was associated with cirrhosis, and hepatitis B virus infection of HCC patients (P<0.05). TCGA database also showed that ZP3 was up-regulated in HCC tissues. Further survival evaluation confirmed that ZP3 expression caused an impact on the overall survival time and disease-free survival time of HCC patients (P<0.05), implying a potential role in HCC prognosis. GSEA analysis indicated that the 187 differential gene sets were mainly involved in 10 signaling pathways, including 5 up-regulated and 5 down-regulated pathways.

Conclusion:

High expression of ZP3 in HCC tissues shows an important role in HCC development and prognosis.
Fibrinolysis in COVID-19: Impact on Clot Lysis and Modulation of Inflammation
Authors: Sousa Lirlândia P. , Sugimoto Michelle A. , Perucci Luiza O. , Tavares Luciana P. , Teixeira Mauro M.
Published: October 2022

COVID-19 is a multisystem disease caused by SARS-CoV-2 and is associated with an imbalance between the coagulation and fibrinolytic systems. Overall, hypercoagulation, hypofibri-nolysis and fibrin-clot resistance to fibrinolysis predispose patients to thrombotic and thromboem-bolic events. In the lungs, the virus triggers alveolar and interstitial fibrin deposition, endothelial dysfunction, and pulmonary intravascular coagulation, all events intrinsically associated with the activation of inflammation and organ injury. Adding to the pathogenesis of COVID-19, there is a positive feedback loop by which local fibrin deposition in the lungs can fuel inflammation and con-sequently dysregulates coagulation, a process known as immunothrombosis. Therefore, fibrinolysis plays a central role in maintaining hemostasis and tissue homeostasis during COVID-19 by cleaning fibrin clots and controlling feed-forward products of coagulation. In addition, components of the fi-brinolytic system have important immunomodulatory roles, as evidenced by studies showing the contribution of Plasminogen/Plasmin (Plg/Pla) to the resolution of inflammation. Herein, we review clinical evidence for the dysregulation of the fibrinolytic system and discuss its contribution to thrombosis risk and exacerbated inflammation in severe COVID-19. We also discuss the current concept of an interplay between fibrinolysis and inflammation resolution, mirroring the well-known crosstalk between inflammation and coagulation. Finally, we consider the central role of the Plg/Pla system in resolving thromboinflammation, drawing attention to the overlooked consequences of COVID-19-associated fibrinolytic abnormalities to local and systemic inflammation.
Preparation of Loratadine Orally Disintegrating Tablets by Semi-solid
Extrusion 3D Printing
Authors: Yi Shaoling , Xie Jingwen , Chen Lingli , Xu Feng
Published: October 2022

Background:

The orally disintegrating tablets (ODTs) are especially suitable for elders and children with dysphagia, who need to be customized dosages.

Objectives:

This study aimed to prepare orally disintegrating tablets (ODTs) which can be customized as drug content by using semi-solid 3D printing pressure extrusion technology, with water insoluble and thermally unstable drug loratadine.

Methods:

The influence of binder concentration, disintegrating agent dosage and ratio mannitol: cellulose on formability and disintegration time was investigated. The properties of orally disintegrating tablets were investigated by ATR-FTIR, XRPD, DSC and SEM. The correlation formula between tablet bottom area and drug content was established.

Results:

The formulation was optimized, and contained loratadine 3 g, cellulose 4 g, mannitol 2 g, carboxy methyl starch sodium 1g, 6% PVP K30 16 ml. The disintegration time was less than 60 s with a infilling percentage of 60%, and the disintegration time was less than 30 s with a infilling percentage of 40%. There was no detectable interaction between loratadine and the selected excipients by the analysis of ATR-FTIR, DSC and XRPD. The structure of the tablets was porous, and the drug was dissolved completely within 10 min. The drug content (x) of the tablet and the bottom area (y) of the tablet showed a linear fitting relationship, y = 3.8603x - 0.7176, r2 = 0.9993.

Conclusion:

Semi-solid extrusion of 3D printing technology was applied to prepare loratadine orally disintegrating tablets with customized drug content, which provides an alternative method for the research of customized preparation.
Synovial Chondromatosis of the Shoulder in Rheumatoid Arthritis: A Case
Report and Brief Review of the Literature
Authors: Tekaya Aicha Ben , Hamdi Ons , Bellil Mehdi , Saidane Olfa , Rouached Leila , Bouden Selma , Tekaya Rawdha , Salah Mohamed Ben , Mahmoud Ines , Abdelmoula Leila
Published: October 2022

Background:

Synovial chondromatosis is an uncommon benign condition characterized by synovial membrane proliferation and metaplasia. Synovial chondromatosis cases in patients with rheumatoid arthritis have been reported. However, involvement of the glenohumeral joint is rare.

Case presentation:

We herein report a case of a rare association of synovial chondromatosis involving the shoulder in a rheumatoid arthritis patient. The symptoms have improved with anti-tumor necrosis factor drugs. Consequently, there was no need for invasive therapy for treating synovial chondromatosis.

Conclusions:

Synovial chondromatosis can be aggressive and destructive. More trials are needed to establish a better clinical diagnostic strategy and pharmacological management.
Pseudocereals: Nutrition, Health Benefits, and Potential Applications in
Gluten-free Food Product Developments
Authors: Wanniarachchi Piyumi Chathurangi , Pavalakumar Dayani , Jayasinghe Madhura Arunoda
Published: October 2022

Since the dawn of time, cereals have been acknowledged to play a critical role in meeting human food demand as they are capable of providing significant amounts of macro and micronutrients and calories to an individual’s diet. Pseudocereals, on the other hand, are also naturally high in these critical nutrients but have not been fully investigated for their ability to be used in large-scale manufacturing activities. Although pseudocereals grains provide a reasonable advantage to their users, in terms of nutrition and health benefits many people, still people do not get the whole advantage out of them. Pseudocereals are edible seeds from the class Dicotyledonae, and represent increasingly popular gluten-free grains with high nutritional value in human diets. Pseudocereals are high in starch, fiber, proteins, minerals, vitamins, and phytochemicals (especially phenolics) which dispense profuse health benefits. They can lower the risk of chronic diseases such as diabetes, cancer, and cardiovascular diseases. Therefore, this work aims to provide an outline of the major types, nutritional and phytochemical composition, health benefits, and potential applications of the three most commonly consumed pseudocereal grains: amaranth, quinoa, and buckwheat to popularize these grains among people. Commercialization of these pseudocereals containing products would aid in combating a variety of health-related issues. Amaranth, quinoa, and buckwheat are gluten-free sources and contain no prolamins that are harmful to celiac disease patients. Therefore, pseudocereal-incorporated gluten-free foods would symbolize a step forward in guaranteeing sufficient input of nutrients in celiac disease patients.
Computational Analysis of Bacopa monnieri (L.) Wettst. Compounds for
Drug Development against Neurodegenerative Disorders
Authors: Sangeet Satyam , Khan Arshad , Mahanta Saurov , Roy Nabamita , Das Sanjib Kumar , Mohanta Yugal Kishore , Saravanan Muthupandian , Tag Hui , Hui Pallabi Kalita
Published: October 2022

Aim:

With several experimental studies establishing the role of Bacopa monnieri as an effective
neurological medication, less focus has been employed to explore how effectively Bacopa monnieri brings
about this property. The current work focuses on understanding the molecular interaction of the phytochemicals
of the plant against different neurotrophic factors to explore their role and potential as potent
anti-neurodegenerative drugs.

Background:

Neurotrophins play a crucial role in the development and regulation of neurons. Alterations
in the functioning of these Neurotrophins lead to several Neurodegenerative Disorders. Albeit engineered
medications are accessible for the treatment of Neurodegenerative Disorders, due to their numerous side
effects, it becomes imperative to formulate and synthesize novel drug candidates.

Objective:

This study aims to investigate the potential of Bacopa monnieri phytochemicals as potent antineurodegenerative
drugs by inspecting the interactions between Neurotrophins and target proteins.

Methods:

The current study employs molecular docking and molecular dynamic simulation studies to examine
the molecular interactions of phytochemicals with respective Neurotrophins. Further inspection of
the screened phytochemicals was performed to analyze the ADME-Tox properties in order to classify the
screened phytochemicals as potent drug candidates.

Results:

The phytochemicals of Bacopa monnieri were subjected to in-silico docking with the respective
Neurotrophins. Vitamin E, Benzene propanoic acid, 3,5-bis (1,1- dimethylethyl)- 4hydroxy-, methyl ester
(BPA), Stigmasterol, and Nonacosane showed an excellent binding affinity with their respective Neurotrophins
(BDNF, NT3, NT4, NGF). Moreover, the molecular dynamic simulation studies revealed that BPA
and Stigmasterol show a very stable interaction with NT3 and NT4, respectively, suggesting their potential
role as a drug candidate. Nonacosane exhibited a fluctuating binding behavior with NGF which can be accounted
for by its long linear structure. ADME-Tox studies further confirmed the potency of these phytochemicals
as BPA violated no factors and Vitamin E, Stigmasterol and Nonacosane violated 1 factor for
Lipinski’s rule. Moreover, their high human intestinal absorption and bioavailability score along with their
classification as non-mutagen in the Ames test makes these compounds more reliable as potent antineurodegenerative
drugs.

Conclusion:

Our study provides an in-silico approach toward understanding the anti-neurodegenerative
property of Bacopa monnieri phytochemicals and establishes the role of four major phytochemicals which
can be utilized as a replacement for synthetic drugs against several neurodegenerative disorders.
Analytical and Bioanalytical Methods for the Quantification of the Nucleotide
Polymerase Inhibitor - Sofosbuvir: A Critical Review (2015-2021)
Authors: Pathak Shilpi , Bhardwaj Muskan , Godela Ramreddy
Published: October 2022

Sofosbuvir is a regularly used antiviral medication that was approved for clinical usage in hepatitis C patients. Sofosbuvir belongs to the nucleotide analog drug class, and it operates by inhibiting hepatitis C NS5B protein. This study focuses on the many analytical methods for detecting and quantifying Sofosbuvir in pharmaceutical formulations, biological samples, and fixed dosage combinations. Chromatographic techniques, electro-analytical methods, chemometric procedures, and optical approaches are just a few of the approaches mentioned in the literature. The most often used methods for the analysis of Sofosbuvir are HPLC-based methods with UV/Vis spectrophotometric, fluorescence, and mass spectrometric detection. This article could be extremely useful in the creation of upcoming Sofosbuvir analytical approaches or investigations.
Animal Models and Methods of Myocardial Infarction Induction and the
Role of Tissue Engineering in the Regeneration of Damaged Myocardium
Authors: Fakhr Massoumeh Jabbari , Dezfouli Mohammad Reza Mokhber , Chaleshtori Sirous Sadeghian
Published: October 2022

Introduction of an animal experimental model for myocardial infarction (MI) has particular importance. Research done on large animals provides valuable information for the researchers because of the similar characteristics of their hearts compared with human, but the cost of purchasing and maintenance of them is high. In comparison, using small animals has advantages such as they are easy to work with and have low purchase and maintenance cost. However, in some of these animals, due to less similarity of the heart to human, cannot simulate the natural pathogenesis of human MI. Moreover, there are different methods for induction of MI in animals, each has its own advantages and disadvantages. However, the method must be chosen that can simulate the natural pathogenesis of MI with minimal complication. Today, attempts are being made for myocardial regeneration after MI using the direct transplantation of stem cells or with an engineered scaffold. The scaffold creates a 3D ambience for the cultured cells. The task of tissue engineering is to optimize the scaffold with appropriate systems for separation, proliferation, and differentiation of the desired cells until they are capable to promote the three-dimensional and appropriate growth of the tissue.The purpose of tissue engineering in cardiac is use of scaffold and cell in the damaged area, followed by the improvement of the heart function through the automatic pulsation, communication with the host vessels, and electrical coupling with the myocardium, eventually creating a force to increase the heart function.
Effect of Online Training in the Continuing Education of Nurses in Hospitals in the Casablanca-Settat Region
Authors: Lhbibani Amina , Daaif Jabran , Lotfi Said , Tridane Malika , Belaaouad Said
Published: October 2022

Context:

Nowadays, e-Learning has become essential for the continuing education of health professionals, especially in developing countries. Its introduction in health care settings guarantees better opportunities for disseminating knowledge and skills.

Objective:

This study aimed to measure the effects of online training “E-learning” on the learning outcomes of nurses in two hospitals in the Casablanca-Settat region with the course “Health planning” as a training theme.

Methods:

This study is an experimental type, including an experimental group that benefited from online training (B, n2 = 30) and a Control group that benefited from face-to-face training (A, n1 = 30). We used a questionnaire to evaluate the nurses' knowledge (general and procedural) in pre and post-training and a questionnaire to evaluate the nurses' satisfaction with using e-learning in continuing education.

Results:

The results show a positive effect of online training on nurses' learning through an increase in knowledge (general and procedural) after comparing the average score in pre and post-training (The p-value is less than 0.05). Also, high satisfaction with the content covered, the methodology used in the e-Learning, and the quality of the platform.

Conclusion:

These results should encourage and motivate those responsible for continuing education to adopt online training as a complementary and promising solution to ensure flexible and continuous continuing education sessions for healthcare personnel.
Perceptions and Experiences of Males who have Sex with Men Regarding Sexual and Reproductive Health Services in Bulawayo, Zimbabwe
Authors: Munyimani Tadios , Nunu Wilfred Njabulo
Published: October 2022

Background:

Sexual and Reproductive Health services are a cornerstone for each nation to achieve Sustainable Development Goal Number 3, which challenges nations to ensure healthy lives and promote the well-being of all ages, including access to SRH services. Generally, stigma and policies against men who have sex with men have heightened the risk of getting and spreading sexually transmitted diseases in this key population. This study, therefore, sought to explore men who have sex with men's perceptions and experiences of sexual and reproductive health services offered in Bulawayo in Zimbabwe.

Methods:

An exploratory, descriptive qualitative study was conducted on twenty-four (24) purposively selected men who had sex with men identified through Sexual Rights Centre in Bulawayo. The study participants responded to unstructured interview questions that probed on their lived experiences and perceptions of sexual and reproductive health services offered by health facilities in the city of Bulawayo. The interviews were recorded, transcribed verbatim, coded, and thematically analyzed on MAXQDA Version 20 Pro.

Results:

Findings suggested that men who had sex with men sought a wider range of sexual and reproductive health services that ranged from voluntary counseling and testing, treatment of sexually transmitted infections, and obtaining pre-exposure prophylaxis tablets, among other issues. However, men who had sex with men faced discrimination, stigma, and hostile treatment by some health service providers. This scenario, in some instances, is perceived to have fueled their vulnerability and led to internalized homophobia.

Conclusion:

In pursuit of Sustainable Development Goal Number 3, which challenges all nations to ensure healthy lives and promote well-being at all ages, men who have sex with men are not fully accorded their rights. Therefore, there is a need to reorient health services and align policies to ensure the inclusion of this key population in accessing and utilizing sexual and reproductive health services.
A New Design for Low Flange-wear Railroad Wheelset
Authors: Yao Huiming , Gao Wudi , Yuan Chunping
Published: October 2022

Background:

The wear of wheelsets on curves has always been a problem for rail vehicles; it
is of great significance to research and develop radial components with excellent curve negotiating performance.

Objective:

This paper aims to study and design a wheelset with excellent curve negotiating performance
to reduce wear on the flange. In addition, the dynamic simulation performance of the wheelset is studied.

Methods:

The wheel is divided into the flange part and the tread part; bearings are mounted between the
two, allowing them to rotate at differential speeds, while the tread part maintains a rigid connection with
the axle. Modeling and dynamics simulation of the wheelset is carried out by SOLIDWORKS and
SIMPACK.

Results:

Based on the Archard wear model, it is found that the flange wear amount of the designed
wheelset is significantly reduced compared with the traditional wheelset.

Conclusion:

The results show that the structural design of the wheelset is reasonable, has good curve
negotiating performance, and can greatly reduce the wear of the flange; however, there is still room for
further optimization of the structural design.
Extracción de pectina a partir de la hidrólisis ácida del cacao (Theobroma Cacao L.) y su aplicación en la obtención de biopelículas
Authors: Rodriguez Daniel , Ramirez Garcés Andres Felipe , Altamar Consuegra Astrid del Socorro
Published: October 2022

Diferentes condiciones experimentales fueron empleadas para evaluar el tipo de ácido y el pH adecuados para la extracción de pectina a partir de cáscaras de cacao y su aplicación en la obtención de una biopelicula. Se estudió tipo de ácido: clorhídrico y cítrico, y el pH a niveles 2, 3 y 4 a una temperatura constante de 90°C, las variables respuestas fueron: rendimiento de pectina, % de metoxilo % de esterificación, % de ácido galacturónico y % de acidez. En las extracciones de pectina, se reportó un rendimiento promedio de ácido cítrico para un pH de 2.0 de 2.17%; para un pH 3.0 de 2.56% y el pH de 4.0 de 1.03%; para el ácido clorhídrico se reportó un rendimiento promedio con pH 2.0 de 2.68%; para un pH de 3.0 de 2.13% y para un pH de 4.0 un rendimiento de 0.83%.  La pectina fue caracterizada mediante la técnica de Owens para evaluar variables de acidez libre, peso equivalente y grado de esterificación, adicionalmente se realizó un análisis FTIR para conocer los grupos funcionales. Basados en el análisis del diseño experimental utilizado, se seleccionó la pectina de mejores características para la fabricación de la biopelícula mediante la mezcla de pectina con glicerina como agente plastificante. Se sometió la biopelícula a prueba de biodegradabilidad aerobia, según lo expuesto en la norma ISO 17556 de 2019 donde se obtuvo una pérdida de peso del 18,8% y producción de 53 mg de en 5 días, mostrando una buena capacidad de biodegradabilidad.