bluuebunny/crossref_metadata_2025 huggingface dataset:
Real-Time Hybrid Deep Learning-Based Train Running Safety Prediction Framework of Railway Vehicle
Authors: Lee Hyunsoo , Han Seok-Youn , Park Keejun , Lee Hoyoung , Kwon Taesoo
Published: June 2021

Train running safety is considered one of the key criteria for advanced highway trains and bogies. While a number of existing research studies have focused on its measurement and monitoring, this study proposes a new and effective train running a safety prediction framework. The wheel derail coefficient, wheel rate of load reduction, and wheel lateral pressure are considered the decision variables for the safety framework. Data for actual measured rail conditions and vibration-based signals are used as the input data. However, advanced trains and bogies are influenced more by their inertial structures and mechanisms than by railway conditions and external environments. In order to reflect their inertial influences, past data of output variables are used as recurrent data. The proposed framework shares advantages of a general deep neural network and a recurrent neural network. To prove the effectiveness of the proposed hybrid deep-learning framework, numerical analyses using an actual measured train-railway model and transit simulation are conducted and compared with the existing deep learning architectures.
The Creative Act in the Dialogue between Art and Mathematics
Authors: Arias-Alfonso Andrés F. , Franco Camilo A.
Published: June 2021

This study was developed during 2018 and 2019, with 10th- and 11th-grade students from the Jose Maria Obando High School (Fredonia, Antioquia, Colombia) as the target population. Here, the “art as a method” was proposed, in which, after a diagnostic, three moments were developed to establish a dialogue between art and mathematics. The moments include Moment 1: introduction to art and mathematics as ways of doing art, Moment 2: collective experimentation, and Moment 3: re-signification of education as a model of experience. The methodology was derived from different mathematical-based theories, such as pendulum motion, centrifugal force, solar energy, and Chladni plates, allowing for the exploration of possibilities to new paths of knowledge from proposing the creative act. Likewise, the possibility of generating a broad vision of reality arose from the creative act, where understanding was reached from logical-emotional perspectives beyond the rational vision of science and its descriptions.
Dead-Time Compensation for the First-Order Dead-Time Processes: Towards a Broader Overview
Authors: Huba Mikulas , Bistak Pavol , Vrancic Damir , Zakova Katarina
Published: June 2021

The article reviews the results of a number of recent papers dealing with the revision of the simplest approaches to the control of first-order time-delayed systems. The concise introductory review is extended by an analysis of two discrete-time approaches to dead-time compensation control of stable, integrating, and unstable first-order dead-time processes including simple diagnostics of the model used and focusing on the possibility of simplified but reliable plant modelling. The first approach, based on the first historically known dead-time compensator (DTC) with possible dead-beat performance, is based on the reconstruction of the actual process variables and the compensation of input disturbances by an extended state observer (ESO). Such solutions play an important role both in a disturbance observer (DOB) based control and in an active disturbance rejection control (ADRC). The second approach considered comes from the Smith predictor with two degrees of freedom, which combines feedforward control with output disturbance reconstruction and compensation by the parallel plant model. It is shown that these two approaches offer advantageous properties in the case of actuator limitations, in contrast to the commonly used PID controllers. However, when applied to integrating and unstable first-order systems, the unconstrained and possibly unobservable output disturbance signal of the second solution must be eliminated from the control loop, due to the hidden structural instability of the Smith predictor-like solutions. The modified solutions, usually referred to as filtered Smith predictor (FSP), then no longer provide a disturbance signal and thus no longer fully fit into the concept of Industry 4.0, which is focused on further optimization, predictive maintenance in dynamic systems, diagnosis, fault detection and fault identification of dynamic processes and forms the basis for the digitalization of smart production. Nevertheless, the detailed analysis of the elimination of the unstable disturbance response mode is also worth mentioning in terms of other possible solutions. The application of both approaches to the control of a thermal process shows almost equivalent quality, but with different dependencies on the tuning parameters used. It is confirmed that a more detailed identification of the controlled process and the resulting higher complexity of the control algorithms does not necessarily lead to an increase in the resulting quality of the transients, which underlines the importance of the simplified plant modelling for practice.
A Class of Three-Qubit Contextual Configurations Located in Fano Pentads
Authors: Saniga Metod
Published: June 2021

Given the symplectic polar space of type W(5,2), let us call a set of five Fano planes sharing pairwise a single point a Fano pentad. Once 63 points of W(5,2) are appropriately labeled by 63 non-trivial three-qubit observables, any such Fano pentad gives rise to a quantum contextual set known as a Mermin pentagram. Here, it is shown that a Fano pentad also hosts another, closely related, contextual set, which features 25 observables and 30 three-element contexts. Out of 25 observables, ten are such that each of them is on six contexts, while each of the remaining 15 observables belongs to two contexts only. Making use of the recent classification of Mermin pentagrams (Saniga et al., Symmetry 12 (2020) 534), it was found that 12,096 such contextual sets comprise 47 distinct types, falling into eight families according to the number (3,5,7,…,17) of negative contexts.
On the Verification of the Pedestrian Evacuation Model
Authors: Kubera Petr , Felcman Jiří
Published: June 2021

In this article we deal with numerical solution of macroscopic models of pedestrian movement. From a macroscopic point of view, pedestrian movement can be described by a system of first order hyperbolic equations similar to 2D compressible inviscid flow. For the Pedestrian Flow Equations (PFEs) the density ρ and the velocity v are considered as the unknown variables. In PFEs, the social force is also taken into account, which replaces the outer volume force term used in the fluid flow formulation, e.g., the pedestrian movement is influenced by the proximity of other pedestrians. To be concrete, the desired direction μ of the pedestrian movement is density dependent and is incorporated in the source term. The system of fluid dynamics equations is thus coupled with the equation for μ. The main message of this paper is the verification of this model. Firstly, we propose two approaches for the source term discretization. Secondly, we propose two splitting schemes for the numerical solution of the coupled system. This leads us to four different numerical methods for the PFEs. The novelty of this work is the comparative study of the numerical solutions, which shows, that all proposed methods are in the good agreement.
Evaluation and Selection of the Quality Methods for Manufacturing Process Reliability Improvement—Intuitionistic Fuzzy Sets and Genetic Algorithm Approach
Authors: Gojković Ranka , Đurić Goran , Tadić Danijela , Nestić Snežana , Aleksić Aleksandar
Published: June 2021

The aim of this research is to propose a hybrid decision-making model for evaluation and selection of quality methods whose application leads to improved reliability of manufacturing in the process industry. Evaluation of failures and determination of their priorities are based on failure mode and effect analysis (FMEA), which is a widely used framework in practice combining with triangular intuitionistic fuzzy numbers (TIFNs). The all-existing uncertainties in the relative importance of the risk factors (RFs), their values, applicability of the quality methods, as well as implementation costs are described by pre-defined linguistic terms which are modeled by the TIFNs. The selection of quality methods is stated as the rubber knapsack problem which is decomposed into subproblems with a certain number of solution elements. The solution of this problem is found by using genetic algorithm (GA). The model is verified through the case study with the real-life data originating from a significant number of organizations from one region. It is shown that the proposed model is highly suitable as a decision-making tool for improving the manufacturing process reliability in small and medium enterprises (SMEs) of process industry.
A 2021 Update on the Use of Liraglutide in the Modern Treatment of ‘Diabesity’: A Narrative Review
Authors: Tilinca Mariana Cornelia , Tiuca Robert Aurelian , Burlacu Alexandru , Varga Andreea
Published: June 2021

Obesity and type 2 diabetes mellitus have become a significant public health problem in the past decades. Their prevalence is increasing worldwide each year, greatly impacting the economic and personal aspects, mainly because they frequently coexist, where the term “diabesity” may be used. The drug class of glucagon-like peptide 1 receptor agonists (GLP-1 RAs) is one of the most modern therapy options in managing these metabolic disorders. This review focuses on the effects of liraglutide, a long-acting GLP-1 RA, in diabesity and non-diabetic excess weight. This drug class improves glycemic control by enhancing insulin secretion from the beta-pancreatic cells and inhibiting glucagon release. Furthermore, other effects include slowing gastric emptying, increasing postprandial satiety, and reducing the appetite and food consumption by influencing the central nervous system, with weight reduction effects. It also reduces cardiovascular events and has positive effects on blood pressure and lipid profile. A lower-dose liraglutide (1.2 or 1.8 mg/day) is used in patients with diabetes, while the higher dose (3.0 mg/day) is approved as an anti-obesity drug. In this review, we have summarized the role of liraglutide in clinical practice, highlighting its safety and efficacy as a glucose-lowering agent and a weight-reduction drug in patients with and without diabetes.
A Review on Polymer Precursors of Carbon Molecular Sieve Membranes for Olefin/Paraffin Separation
Authors: Kim Seong-Joong , Kwon YongSung , Kim DaeHun , Park Hosik , Cho Young Hoon , Nam Seung-Eun , Park You-In
Published: June 2021

Carbon molecular sieve (CMS) membranes have been developed to replace or support energy-intensive cryogenic distillation for olefin/paraffin separation. Olefin and paraffin have similar molecular properties, but can be separated effectively by a CMS membrane with a rigid, slit-like pore structure. A variety of polymer precursors can give rise to different outcomes in terms of the structure and performance of CMS membranes. Herein, for olefin/paraffin separation, the CMS membranes derived from a number of polymer precursors (such as polyimides, phenolic resin, and polymers of intrinsic microporosity, PIM) are introduced, and olefin/paraffin separation properties of those membranes are summarized. The effects from incorporation of inorganic materials into polymer precursors and from a pyrolysis process on the properties of CMS membranes are also reviewed. Finally, the prospects and future directions of CMS membranes for olefin/paraffin separation and aging issues are discussed.
Mesenchymal Stem Cells Do Not Lose Direct Labels Including Iron Oxide Nanoparticles and DFO-89Zr Chelates through Secretion of Extracellular Vesicles
Authors: Gao Yue , Jablonska Anna , Chu Chengyan , Walczak Piotr , Janowski Miroslaw
Published: June 2021

Rapidly ageing populations are beset by tissue wear and damage. Stem cell-based regenerative medicine is considered a solution. Years of research point to two important aspects: (1) the use of cellular imaging to achieve sufficient precision of therapeutic intervention, and the fact that (2) many therapeutic actions are executed through extracellular vesicles (EV), released by stem cells. Therefore, there is an urgent need to interrogate cellular labels in the context of EV release. We studied clinically applicable cellular labels: superparamagnetic iron oxide nanoparticles (SPION), and radionuclide detectable by two main imaging modalities: MRI and PET. We have demonstrated effective stem cell labeling using both labels. Then, we obtained EVs from cell cultures and tested for the presence of cellular labels. We did not find either magnetic or radioactive labels in EVs. Therefore, we report that stem cells do not lose labels in released EVs, which indicates the reliability of stem cell magnetic and radioactive labeling, and that there is no interference of labels with EV content. In conclusion, we observed that direct cellular labeling seems to be an attractive approach to monitoring stem cell delivery, and that, importantly, labels neither locate in EVs nor affect their basic properties.
Regulation of GABAA Receptors Induced by the Activation of L-Type Voltage-Gated Calcium Channels
Authors: Gravielle María Clara
Published: June 2021

GABAA receptors are pentameric ion channels that mediate most synaptic and tonic extrasynaptic inhibitory transmissions in the central nervous system. There are multiple GABAA receptor subtypes constructed from 19 different subunits in mammals that exhibit different regional and subcellular distributions and distinct pharmacological properties. Dysfunctional alterations of GABAA receptors are associated with various neuropsychiatric disorders. Short- and long-term plastic changes in GABAA receptors can be induced by the activation of different intracellular signaling pathways that are triggered, under physiological and pathological conditions, by calcium entering through voltage-gated calcium channels. This review discusses several mechanisms of regulation of GABAA receptor function that result from the activation of L-type voltage gated calcium channels. Calcium influx via these channels activates different signaling cascades that lead to changes in GABAA receptor transcription, phosphorylation, trafficking, and synaptic clustering, thus regulating the inhibitory synaptic strength. These plastic mechanisms regulate the interplay of synaptic excitation and inhibition that is crucial for the normal function of neuronal circuits.
Gradient NMR Method for Studies of Water Translational Diffusion in Plants
Authors: Anisimov Alexander
Published: June 2021

The review of a retrospective nature shows the stages of development of the spin-echo NMR method with constant and pulsed gradient of the magnetic field (gradient NMR) for the study of water diffusion in plant roots. The history of the initial use of gradient NMR for plants, in which it was not possible to experimentally confirm the bound state of water in cells, is described. The work presents the main ideas on which the technology of measuring diffusion by the spin-echo NMR method is built. Special attention is paid to the manifestations and record of the restricted diffusion phenomenon, permeability of membranes, along with the finite formulae used in real experiments. As examples, it gives the non-trivial results of studies of water transfer in roots through the symplastic system, from cell to cell through intercellular contacts with plasmodesmata, through aquaporins, transfer under the influence of changes in external pressure, and the composition of the gas atmosphere.
Post-Processing of Cold Sprayed Ti-6Al-4V Coatings by Mechanical Peening
Authors: Maharjan Niroj , Bhowmik Ayan , Kum Chunwai , Hu Jiakun , Yang Yongjing , Zhou Wei
Published: June 2021

Cold spray is an emerging additive manufacturing technology used in the aerospace industry to repair damaged components made of expensive metal alloys. The cold sprayed layer is prone to surface integrity issues such as high porosity and inadequate bonding at the substrate-coating interface, which may cause premature failure of the repaired component. This study explored the use of mechanical peening as a post-processing method to improve the surface integrity of the cold sprayed component by modifying mechanical properties near the surface. Two mechanical peening processes, deep cold rolling (DCR) and controlled hammer peening (CHP), were utilized to improve cold sprayed Ti-6Al-4V coating on the Ti-6Al-4V substrate. Experimental results indicate that DCR and CHP increase the strength of the bond between the coating and substrate due to introduction of compressive residual stresses. In addition, porosity is also reduced by as much as 71%. The improvement is attributed to both the compacting effect of peening processes and the increment in the volume fraction of deformed regions.
The Effect of Different Annealing Strategies on the Microstructure Development and Mechanical Response of Austempered Steels
Authors: Hernandez-Duran Eliseo , Corallo Luca , Ros-Yanez Tanya , Castro-Cerda Felipe , Petrov Roumen H.
Published: June 2021

This study focuses on the effect of non-conventional annealing strategies on the microstructure and related mechanical properties of austempered steels. Multistep thermo-cycling (TC) and ultrafast heating (UFH) annealing were carried out and compared with the outcome obtained from a conventionally annealed (CA) 0.3C-2Mn-1.5Si steel. After the annealing path, steel samples were fast cooled and isothermally treated at 400 °C employing the same parameters. It was found that TC and UFH strategies produce an equivalent level of microstructural refinement. Nevertheless, the obtained microstructure via TC has not led to an improvement in the mechanical properties in comparison with the CA steel. On the other hand, the steel grade produced via a combination of ultrafast heating annealing and austempering exhibits enhanced ductility without decreasing the strength level with respect to TC and CA, giving the best strength–ductility balance among the studied steels. The outstanding mechanical response exhibited by the UFH steel is related to the formation of heterogeneous distribution of ferrite, bainite and retained austenite in proportions 0.09–0.78–0.14. The microstructural formation after UFH is discussed in terms of chemical heterogeneities in the parent austenite.
A Methodology to Determine the Effective Plastic Zone Size Around Blunt V-Notches under Mixed Mode I/II Loading and Plane-Stress Conditions
Authors: Torabi Ali Reza , Shahbazian Behnam , Mirsayar Mirmilad , Cicero Sergio
Published: June 2021

The determination of the ductile failure behavior in engineering components weakened by cracks and notches is greatly dependent on the estimation of the plastic zone size (PZS) and, particularly, the effective plastic zone size (EPZS). Usually, time-consuming complex elastic–plastic analyses are required for the determination of the EPZS. Such demanding procedures can be avoided by employing analytical methods and by taking advantage of linear elastic analyses. In this sense, this work proposed a methodology for determining the PZS around the tip of blunt V-notches subjected to mixed mode I/II loading and plane-stress conditions. With this aim, firstly, existing approximate mathematical expressions for the elastic stress field near round-tip V-notches reported in the literature are presented. Next, Irwin’s approach (fundamentally proposed for sharp cracks) and a yield criterion (von Mises or Tresca) were applied and are presented. With the aim of verifying the proposed methodology, elastic–plastic finite element analyses were performed on virtual AISI 304 steel V-notched specimens. It was shown that the analytical formulations presented cannot estimate the complete shape of the plastic zone. However, the EPZS, which is crucial for predicting the type of ductile failure in notched members, can be successfully estimated.
Roll Bonding of Al-Based Composite Reinforced with C10 Steel Expanded Mesh Inlay
Authors: Frolov Yaroslav , Nosko Maxim , Samsonenko Andrii , Bobukh Oleksandr , Remez Oleg
Published: June 2021

The most complex issue related to the design of high efficiency composite materials is the behavior of the reinforcing component during the bonding process. This study presents numerical and experimental investigations of the shape change in the reinforcing inlay in an aluminum-steel mesh-aluminum composite during roll-bonding. A flat composite material consisting of two outer strips of an EN AW 1050 alloy and an inlay of expanded C10 steel mesh was obtained via hot roll bonding with nominal rolling reductions of 20%, 30%, 40% and 50% at a temperature of 500 °C. The experimental procedure was carried out using two separate rolling mills with diameters equal to 135 and 200 mm, respectively. A computer simulation of the roll bonding was performed using the finite element software QForm 9.0.10 by Micas Simulations Limited, Oxford, UK. The distortion of the mesh evaluated via the change in angle between its strands was described using computer tomography scanning. The dependence of the absorbed impact energy of the roll bonded composite on the parameters of the deformation zone was found. The results of the numerical simulation of the steel mesh shape change during roll bonding concur with the data from micro-CT scans of the composites. The diameter of rolls applied during the roll bonding, along with rolling reduction and temperature, have an influence on the resulting mechanical properties, i.e., the absorbed bending energy. Generally, the composites with reinforcement exhibit up to 20% higher impact energy in comparison with the non-reinforced composites.
Primary Metabolite Profile Changes in Coffea spp. Promoted by Single and Combined Exposure to Drought and Elevated CO2 Concentration
Authors: Rodrigues Ana M. , Jorge Tiago , Osorio Sonia , Pott Delphine M. , Lidon Fernando C. , DaMatta Fábio M. , Marques Isabel , Ribeiro-Barros Ana I. , Ramalho José C. , António Carla
Published: June 2021

Climate change scenarios pose major threats to many crops worldwide, including coffee. We explored the primary metabolite responses in two Coffea genotypes, C. canephora cv. Conilon Clone 153 and C. arabica cv. Icatu, grown at normal (aCO2) or elevated (eCO2) CO2 concentrations of 380 or 700 ppm, respectively, under well-watered (WW), moderate (MWD), or severe (SWD) water deficit conditions, in order to assess coffee responses to drought and how eCO2 can influence such responses. Primary metabolites were analyzed with a gas chromatography time-of-flight mass spectrometry metabolomics platform (GC-TOF-MS). A total of 48 primary metabolites were identified in both genotypes (23 amino acids and derivatives, 10 organic acids, 11 sugars, and 4 other metabolites), with differences recorded in both genotypes. Increased metabolite levels were observed in CL153 plants under single and combined conditions of aCO2 and drought (MWD and SWD), as opposed to the observed decreased levels under eCO2 in both drought conditions. In contrast, Icatu showed minor differences under MWD, and increased levels (especially amino acids) only under SWD at both CO2 concentration conditions, although with a tendency towards greater increases under eCO2. Altogether, CL153 demonstrated large impact under MWD, and seemed not to benefit from eCO2 in either MWD and SWD, in contrast with Icatu.
Enhancement of Seawater Stress Tolerance in Barley by the Endophytic Fungus Aspergillus ochraceus
Authors: Badawy Ali A. , Alotaibi Modhi O. , Abdelaziz Amer M. , Osman Mahmoud S. , Khalil Ahmed M. A. , Saleh Ahmed M. , Mohammed Afrah E. , Hashem Amr H.
Published: June 2021

Symbiotic plant-fungi interaction is a promising approach to alleviate salt stress in plants. Moreover, endophytic fungi are well known to promote the growth of various crop plants. Herein, seven fungal endophytes were screened for salt tolerance; the results revealed that Aspergillus ochraceus showed a great potentiality in terms of salt tolerance, up to 200 g L−1. The indole acetic acid (IAA) production antioxidant capacity and antifungal activity of A. ochraceus were evaluated, in vitro, under two levels of seawater stress, 15 and 30% (v/v; seawater/distilled water). The results illustrated that A. ochraceus could produce about 146 and 176 µg mL−1 IAA in 15 and 30% seawater, respectively. The yield of IAA by A. ochraceus at 30% seawater was significantly higher at all tryptophan concentrations, as compared with that at 15% seawater. Moreover, the antioxidant activity of ethyl acetate extract of A. ochraceus (1000 µg mL−1) at 15 and 30% seawater was 95.83 ± 1.25 and 98.33 ± 0.57%, respectively. Crude extracts of A. ochraceus obtained at 15 and 30% seawater exhibited significant antifungal activity against F. oxysporum, compared to distilled water. The irrigation of barley plants with seawater (15 and 30%) caused notable declines in most morphological indices, pigments, sugars, proteins, and yield characteristics, while increasing the contents of proline, malondialdehyde, and hydrogen peroxide and the activities of antioxidant enzymes. On the other hand, the application of A. ochraceus mitigated the harmful effects of seawater on the growth and physiology of barley plants. Therefore, this study suggests that the endophytic fungus A. ochraceus MT089958 could be applied as a strategy for mitigating the stress imposed by seawater irrigation in barley plants and, therefore, improving crop growth and productivity.
The RNA Chaperone Hfq Participates in Persistence to Multiple Antibiotics in the Fish Pathogen Yersinia ruckeri
Authors: Calderón Iván L. , Barros María José , Montt Fernanda , Gil Fernando , Fuentes Juan A. , Acuña Lillian G.
Published: June 2021

Yersinia ruckeri causes outbreaks of enteric redmouth disease in salmon aquaculture all over the world. The transient antibiotic tolerance exhibited by bacterial persisters is commonly thought to be responsible for outbreaks; however, the molecular factors underlying this behavior have not been explored in Y. ruckeri. In this study, we investigated the participation of the RNA chaperone Hfq from Y. ruckeri in antibiotic persistence. Cultures of the hfq-knockout mutant (Δhfq) exhibited faster replication, increased ATP levels and a more reductive environment than the wild type. The growth curves of bacteria exposed to sublethal concentrations of ampicillin, oxolinic acid, ciprofloxacin and polymyxin B revealed a greater susceptibility for the Δhfq strain. The time-kill curves of bacteria treated with the antibiotics mentioned above and florfenicol, using inoculums from exponential, stationary and biofilm cultures, demonstrated that the Δhfq strain has significant defects in persister cells production. To shed more light on the role of Hfq in antibiotic persistence, we analyzed its dependence on the (p)ppGpp synthetase RelA by determining the persister cells production in the absence of the relA gene. The ΔrelA and ΔrelAΔhfq strains displayed similar defects in persister cells formation, but higher than Δhfq strain. Similarly, stationary cultures of the ΔrelA and ΔrelAΔhfq strains exhibited comparable levels of ATP but higher than that of the Δhfq strain, indicating that relA is epistatic over hfq. Taken together, our findings provide valuable information on antibiotic persistence in Y. ruckeri, shedding light on the participation of Hfq in the persistence phenomenon.
Types of Tellurium Mineralization of Gold Deposits of the Aldan Shield (Southern Yakutia, Russia)
Authors: Kondratieva Larisa A. , Anisimova Galina S. , Kardashevskaia Veronika N.
Published: June 2021

The published and original data on the tellurium mineralization of gold ore deposits of the Aldan Shield are systematized and generalized. The gold content is related to hydrothermal-metasomatic processes caused by Mesozoic igneous activity of the region. The formation of tellurides occurred at the very late stages of the generation of gold mineralization of all existing types of metasomatic formations. 29 tellurium minerals, including 16 tellurides, 5 sulfotellurides and 8 tellurates have been identified. Tellurium minerals of two systems predominate: Au-Bi-Te and Au-Ag-Te. Gold is not only in an invisible state in sulfides and in the form of native gold of different fineness, but also is part of a variety of compounds: montbrayite, calaverite, sylvanite, krennerite and petzite. In the gold deposits of the Aldan Shield, three mineral types are distinguished: Au-Ag-Te, Au-Bi-Te, and also a mixed one, which combines the mineralization of both systems. The decrease in the fineness of native gold is consistent with the sequence and temperatures of the formation of Te minerals and associated mineral paragenesis from the epithermal–mesothermal Au-Bi-Te to epithermal Au-Ag-Te. The conducted studies allowed us to determine a wide variety of mineral species and significantly expand the area of distribution of Au-Te mineralization that indicates its large-scale regional occurrence in the Aldan Shield.
Iron Ore Slimes Flotation Tests Using Column and Amidoamine Collector without Depressant
Authors: Filippov Lev O. , Silva Klaydison , Piçarra Alexandre , Lima Neymayer , Santos Iranildes , Bicalho Leandro , Filippova Inna V. , Peres Antonio Eduardo Clark
Published: June 2021

This work describes the concentration of iron ore slimes on a pilot scale by using a 500-mm diameter flotation column and a novel collector, which renders the use of a depressant unnecessary. The pilot column was operated in series with the industrial plant Vargem Grande 2 (Iron Quadrangle, Brazil) receiving, as feed, part of the underflow from the desliming thickener. These pilot tests represented only the rougher stage of a flotation circuit. The novel collector used was an amidoamine (average collector dosage of 160 g/t), and the tests were carried out in the absence of starch, at pH 10.5 and with bubbles/microbubbles generated by cavitation tube. It was possible to achieve a concentrate, by reverse flotation, with an average iron content of 53% and an average metallurgical recovery of 91.5% The recovery of the silica in the froth was 53.1% in average for one stage of flotation. The high variability of the slime characteristics rendered difficult the stabilization of the SiO2 recovery; however, the applicability of the amidoamine collector was proven. In an industrial scale circuit, the use of online analyzers for Fe and SiO2 content and the adoption of control logics based on the adjustment of parameters such as reagents dosage and washing water flow rate adjustment should contribute to the optimization of the results obtained in the pilot scale tests. Further studies adding a cleaner concentration stage should be performed.
Geopolymers Based on Mechanically Activated Fly Ash Blended with Dolomite
Authors: Kalinkin Alexander M. , Gurevich Basya I. , Kalinkina Elena V. , Chislov Mikhail V. , Zvereva Irina A.
Published: June 2021

This study reports the effect of natural dolomite addition to fly ash and the mechanical activation of this blend on the geopolymerization process. Dolomite was replaced with fly ash at 1, 3, 5, and 10 wt.%. Geopolymers were synthesized at ambient temperature using NaOH solution as an alkaline agent. The geopolymerization process, reactivity of the raw material, compressive strength, and microstructure were studied using X-ray diffraction, Fourier-transform infrared spectroscopy, thermogravimetry, and scanning electron microscopy. It was shown that blending fly ash with dolomite and mechanical activation improved the geopolymer strength, especially during the early age of curing. For geopolymers prepared using a 90% fly ash + 10% dolomite blend cured for 7 d, the strengths were 8.2-, 2.3-, and 1.4-fold higher than those for geopolymers prepared using 100% FA for 30 s, 180 s, and 400 s milling times, respectively. A simple method for evaluating the increments of mechanical activation, carbonate additives, and the synergistic effect in the increase in the compressive strength of the composite geopolymer is proposed.
A Review of Tungsten Resources and Potential Extraction from Mine Waste
Authors: Han Zhengdong , Golev Artem , Edraki Mansour
Published: June 2021

Tungsten is recognized as a critical metal due to its unique properties, economic importance, and limited sources of supply. It has wide applications where hardness, high density, high wear, and high-temperature resistance are required, such as in mining, construction, energy generation, electronics, aerospace, and defense sectors. The two primary tungsten minerals, and the only minerals of economic importance, are wolframite and scheelite. Secondary tungsten minerals are rare and generated by hydrothermal or supergene alteration rather than by atmospheric weathering. There are no reported concerns for tungsten toxicity. However, tungsten tailings and other residues may represent severe risks to human health and the environment. Tungsten metal scrap is the only secondary source for this metal but reprocessing of tungsten tailings may also become important in the future. Enhanced gravity separation, wet high-intensity magnetic separation, and flotation have been reported to be successful in reprocessing tungsten tailings, while bioleaching can assist with removing some toxic elements. In 2020, the world’s tungsten mine production was estimated at 84 kt of tungsten (106 kt WO3), with known tungsten reserves of 3400 kt. In addition, old tungsten tailings deposits may have great potential for exploration. The incomplete statistics indicate about 96 kt of tungsten content in those deposits, with an average grade of 0.1% WO3 (versus typical grades of 0.3–1% in primary deposits). This paper aims to provide an overview of tungsten minerals, tungsten primary and secondary resources, and tungsten mine waste, including its environmental risks and potential for reprocessing.
Aqua Traiana, a Roman Infrastructure Embedded in the Present: The Mineralogical Perspective
Authors: Botticelli Michela , Calzolari Laura , De Vito Caterina , Mignardi Silvano , Medeghini Laura
Published: June 2021

Construction materials from the internal ducts of Aqua Traiana, a still operative Roman aqueduct built in 109 AD to supply water to Rome, were characterized by optical microscopy (OM), scanning electron microscopy (SEM-EDS), X-ray powder diffraction (XRPD) and electron microprobe analysis (EMPA). Petrographic analysis and XRPD revealed that mortar aggregates are compatible with Vitruvius’ harena fossicia and allowed the distinction of the original mortars from those of the 17th-century papal restoration. The first showed an amorphous binder while the latter have a typical lime binder. By SEM-EDS and EMPA, the microstructure of mortar aggregates was analyzed and the composition of specific minerals quantified. Microanalysis testifies the Romans’ great expertise in the selection of pozzolanic building materials, giving evidence of the possible use of local tuffs from the Sabatini Volcanic District. It also confirms the exploitation of red pozzolan from the Roman Magmatic Province, specifically from the Alban Hills district. OM also proves a high compatibility with local supplies for bricks and cocciopesto. Of these, the first were fired at moderately low temperature, while the latter show an amorphous binder as in the original Trajan mortars. All building materials thus stand for similar technological choices and a coeval production.
Antiviral Effects of Green Tea EGCG and Its Potential Application against COVID-19
Authors: Wang Ying-Qi , Li Qing-Sheng , Zheng Xin-Qiang , Lu Jian-Liang , Liang Yue-Rong
Published: June 2021

(–)-Epigallocatechin-3-O-gallate (EGCG), the most abundant component of catechins in tea (Camellia sinensis (L.) O. Kuntze), plays a role against viruses through inhibiting virus invasiveness, restraining gene expression and replication. In this paper, the antiviral effects of EGCG on various viruses, including DNA virus, RNA virus, coronavirus, enterovirus and arbovirus, were reviewed. Meanwhile, the antiviral effects of the EGCG epi-isomer counterpart (+)-gallocatechin-3-O-gallate (GCG) were also discussed.
Cheminformatic Characterization of Natural Antimicrobial Products for the Development of New Lead Compounds
Authors: Oselusi Samson Olaitan , Christoffels Alan , Egieyeh Samuel Ayodele
Published: June 2021

The growing antimicrobial resistance (AMR) of pathogenic organisms to currently prescribed drugs has resulted in the failure to treat various infections caused by these superbugs. Therefore, to keep pace with the increasing drug resistance, there is a pressing need for novel antimicrobial agents, especially from non-conventional sources. Several natural products (NPs) have been shown to display promising in vitro activities against multidrug-resistant pathogens. Still, only a few of these compounds have been studied as prospective drug candidates. This may be due to the expensive and time-consuming process of conducting important studies on these compounds. The present review focuses on applying cheminformatics strategies to characterize, prioritize, and optimize NPs to develop new lead compounds against antimicrobial resistance pathogens. Moreover, case studies where these strategies have been used to identify potential drug candidates, including a few selected open-access tools commonly used for these studies, are briefly outlined.
The Modality Card Deck: Co-Creating Multi-Modal Behavioral Expressions for Social Robots with Older Adults
Authors: Pollmann Kathrin
Published: June 2021

Robots have been proposed as intelligent technology that can support the independent living and health of older adults. While significant advances are being made regarding hardware and intelligent software to support autonomous actions of robots, less emphasis has been put on designing robot behavior that is comprehensible and pleasant for older adults. However, good usability and user experience are crucial factors for acceptance and long-term use. One way to actively engage older adults in behavioral design for social robots is participatory design. The Modality Card Deck is proposed, a tool that helps to engage older adults in human-robot interaction design process and participate in design decision for robot behavior. The cards guide the users towards creating ideas for design solutions which are detailed enough to be implemented by interaction designers and software developers. This paper provides a detailed description of the Modality Card Deck and presents an evaluation of the tool in the scope of a case study. In the case study, the card deck was used in participatory design workshops with older adults to develop multi-modal robot behaviors for the Pepper robot and a quiz game application. After describing the procedure of the case study, the workshop results and learnings about working with the Modality Card Deck and older adults are presented.
Anticancer Potential of Temozolomide-Loaded Eudragit-Chitosan Coated Selenium Nanoparticles: In Vitro Evaluation of Cytotoxicity, Apoptosis and Gene Regulation
Authors: Mazarei Madineh , Mohammadi Arvejeh Pooria , Mozafari M. R. , Khosravian Pegah , Ghasemi Sorayya
Published: June 2021

Resistance to temozolomide (TMZ) is the main cause of death in glioblastoma multiforme (GBM). The use of nanocarriers for drug delivery applications is one of the known approaches to overcome drug resistance. This study aimed to investigate the possible effect of selenium–chitosan nanoparticles loaded with TMZ on the efficacy of TMZ on the expression of MGMT, E2F6, and RELA genes and the rate of apoptosis in the C6 cell line. Selenium nanoparticles (SNPs) were loaded with TMZ and then they were coated by Eudragit® RS100 (Eud) and chitosan (CS) to prepare Se@TMZ/Eud-Cs. Physicochemical properties were determined by scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDAX), thermal gravimetric analysis (TGA), Fourier-transform infrared spectroscopy (FTIR), and dynamic light scattering (DLS) methods. Se@TMZ/Eud-Cs was evaluated for loading and release of TMZ by spectrophotometric method. Subsequently, SNPs loaded with curcumin (as a fluorophore) were analyzed for in vitro uptake by C6 cells. Cytotoxicity and apoptosis assay were measured by MTT assay and Annexin-PI methods. Finally, real-time PCR was utilized to determine the expression of MGMT, E2F6, and RELA genes. Se@TMZ/Eud-Cs was prepared with an average size of 200 nm as confirmed by the DLS and microscopical methods. Se@TMZ/Eud-Cs presented 82.77 ± 5.30 loading efficiency with slow and pH-sensitive release kinetics. SNPs loaded with curcumin showed a better uptake performance by C6 cells compared with free curcumin (p-value < 0.01). Coated nanoparticles loaded with TMZ showed higher cytotoxicity, apoptosis (p-value < 0.0001), and down-regulation of MGMT, E2F6, and RELA and lower IC50 value (p-value < 0.0001) than free TMZ and control (p-value < 0.0001) groups. Using Cs as a targeting agent in Se@TMZ/Eud-Cs system improved the possibility for targeted drug delivery to C6 cells. This drug delivery system enhanced the apoptosis rate and decreased the expression of genes related to TMZ resistance. In conclusion, Se@TMZ/Eud-Cs may be an option for the enhancement of TMZ efficiency in GBM treatment.
Characteristics of Plasma Flow for Microwave Plasma Assisted Aerosol Deposition
Authors: Kang In-Je , Cho Chang-Hyun , Chang Hyonu , Jang Soo-Ouk , Park Hyun-Jae , Kim Dae-Gun , Lee Kyung-Min , Kim Ji-Hun
Published: June 2021

To validate the possibility of the developed microwave plasma source with a novel structure for plasma aerosol deposition, the characteristics of the plasma flow velocity generated from the microwave plasma source were investigated by a Mach probe with pressure variation. Simulation with the turbulent model was introduced to deduce calibration factor of the Mach probe and to compare experimental measurements for analyses of collisional plasma conditions. The results show calibration factor does not seem to be a constant parameter and highly dependent on the collision parameter. The measured plasma flow velocity, which witnessed fluctuations produced by a shock flow, was between 400 and 700 m/s. The optimized conditions for microwave plasma assisted aerosol deposition were derived by the results obtained from analyses of the parameters of microwave plasma jet. Under the optimized conditions, Y2O3 coatings deposited on an aluminum substrate were investigated using scanning electron microscope. The results presented in this study show the microwave plasma assisted aerosol deposition with the developed microwave plasma source is highly feasible for thick films with >50 μm.
Inclusion of 2D Transition Metal Dichalcogenides in Perovskite Inks and Their Influence on Solar Cell Performance
Authors: Taurisano Nicola , Bravetti Gianluca , Carallo Sonia , Liang Meiying , Ronan Oskar , Spurling Dahnan , Coelho João , Nicolosi Valeria , Colella Silvia , Gigli Giuseppe , Listorti Andrea , Rizzo Aurora
Published: June 2021

Organic–inorganic hybrid perovskite materials have raised great interest in recent years due to their excellent optoelectronic properties, which promise stunning improvements in photovoltaic technologies. Moreover, two-dimensional layered materials such as graphene, its derivatives, and transition metal dichalcogenides have been extensively investigated for a wide range of electronic and optoelectronic applications and have recently shown a synergistic effect in combination with hybrid perovskite materials. Here, we report on the inclusion of liquid-phase exfoliated molybdenum disulfide nanosheets into different perovskite precursor solutions, exploring their influence on final device performance. We compared the effect of such additives upon the growth of diverse perovskites, namely CH3NH3PbI3 (MAPbI3) and triple-cation with mixed halides Csx (MA0.17FA0.83)(1−x)Pb (I0.83Br0.17)3 perovskite. We show how for the referential MAPbI3 materials the addition of the MoS2 additive leads to the formation of larger, highly crystalline grains, which result in a remarkable 15% relative improvement in power conversion efficiency. On the other hand, for the mixed cation–halide perovskite no improvements were observed, confirming that the nucleation process for the two materials is differently influenced by the presence of MoS2.
Experimental and Computational Analysis of MnO2@V2C-MXene for Enhanced Energy Storage
Authors: Fatima Mahjabeen , Zahra Syedah Afsheen , Khan Saleem Ayaz , Akinwande Deji , Minár Jan , Rizwan Syed
Published: June 2021

Herein, we studied the novel and emerging group of 2D materials namely MXene along with its nanocomposites. This work entails detailed experimental as well as computational study of the electrochemical behavior of vanadium carbide (V2CTx) MXene and MnO2-V2C nanocomposite with varying percentages of MnO2. A specific capacitance of 551.8 F/g was achieved for MnO2-V2C nanocomposite in 1 M KOH electrolyte solution, which is more than two times higher than the gravimetric capacitance of 196.5 F/g obtained for V2C. The cyclic stability achieved for the MnO2-V2C nanocomposite resulted in a retentivity of 96.5% until 5000 cycles. The c-lattice parameter achieved for MXene is 22.6 Å, which was 13.01 Å for MAX phase. The nanocomposite resulted in a c-lattice parameter of 27.2 Å, which showed that the spatial distance between the MXene layers was efficiently obtained. The method of wet etching was used for the preparation of pristine MXene and the liquid phase precipitation method was opted for the synthesis of the MnO2-V2C nanocomposite. Density functional theory calculation was exercised so as to complement the experimental results and to understand the microscopic details, such as structure stability and electronic structure. The current report presents a comprehensive experimental and computational study on 2D MXenes for future energy storage applications.
First-Principles Study of Au-Doped InN Monolayer as Adsorbent and Gas Sensing Material for SF6 Decomposed Species
Authors: Peng Ruochen , Zhou Qu , Zeng Wen
Published: June 2021

As an insulating medium, sulfur hexafluoride (SF6) is extensively applied to electrical insulation equipment to ensure its normal operation. However, both partial discharge and overheating may cause SF6 to decompose, and then the insulation strength of electrical equipment will be reduced. The adsorption properties and sensing mechanisms of four SF6 decomposed components (HF, SO2, SOF2 and SO2F2) upon an Au-modified InN (Au-InN) monolayer were studied in this work based on first-principles theory. Meanwhile, the adsorption energy (Ead), charge transfer (QT), deformation charge density (DCD), density of states (DOS), frontier molecular orbital and recovery property were calculated. It can be observed that the structures of the SO2, SOF2 and SO2F2 molecules changed significantly after being adsorbed. Meanwhile, the Ead and QT of these three adsorption systems are relatively large, while that of the HF adsorption system is the opposite. These phenomena indicate that Au-InN monolayer has strong adsorption capacity for SO2, SOF2 and SO2F2, and the adsorption can be identified as chemisorption. In addition, through the analysis of frontier molecular orbital, it is found that the conductivity of Au-InN changed significantly after adsorbing SO2, SOF2 and SO2F2. Combined with the analysis of the recovery properties, since the recovery time of SO2 and SO2F2 removal from Au-InN monolayer is still very long at 418 K, Au-InN is more suitable as a scavenger for these two gases rather than as a gas sensor. Since the recovery time of the SOF2 adsorption system is short at 418 K, and the conductivity of the system before and after adsorption changes significantly, Au-InN is an ideal SOF2 gas-sensing material. These results show that Au-InN has broad application prospects as an SO2, SOF2 and SO2F2 scavenger and as a resistive SOF2 sensor, which is of extraordinary meaning to ensure the safe operation of power systems. Our calculations can offer a theoretical basis for further exploration of gas adsorbent and resistive sensors prepared by Au-InN.