bluuebunny/crossref_metadata_2025 huggingface dataset:
Физическая культура и спорт в жизни современного общества
Authors: Демченко Д.С.
Published: May 2023

В данной статье я рассмотрела роль физической культуры и спорта в жизни людей. В ходе рассмотрения были изучены основы физической культуры. Отмечается также положительная роль физической активности в повседневной жизни на общее состояние организма человека.
Политика идентичности на Северном Кавказе: экспертное сообщество об успехах и проблемах ее реализации
Authors: Гриценко Г.Д.
Published: May 2023

В статье представлены экспертные оценки проводимой на Северном Кавказе политике идентичности. Полученный в ходе опроса информационный материал позволил сделать вывод, что в северокавказском регионе для политики идентичности характерна непоследовательность, требуется ее структуризация и систематизация. Основные направления корректировки политики идентичности в регионе и были предложены экспертами.
L’impact du profil de l’entrepreneur sur l’échec entrepreneuriat
Authors: Ben Zarroug Houda , Affes Habib
Published: May 2023

Les caractéristiques de l’entrepreneur forment sa conception de l’environnement. Elles consistent en des associations que l’individu fait à l’égard d’un objet ou d’un sujet donné. Par exemple, un entrepreneur peut être associé à différents concepts. Certains peuvent considérer qu’il s’agit d’un homme d’action, d’un inventeur alors que d’autres peuvent le voir comme un gestionnaire ou encore quelqu’un qui n’est intéressé que par l’argent. Il en va de même avec l’esprit d’entreprise. L’esprit d’entreprise est une question de mentalité. Il ne s'agit pas seulement de démarrer une entreprise, mais cela peut être perçu comme tel par beaucoup. Franke et Lüthje (2003) ont montré que les motivations sont directement affectées par les caractéristiques spécifiques d'un individu. Par conséquent, l'image de l'homme d'affaires concernant les facteurs affectant le développement de l'entrepreneuriat et les obstacles au démarrage d'une entreprise sont des éléments qui peuvent avoir un impact sur les moteurs et l'attitude générale à l'égard de l'entrepreneuriat. Parmi les seules attitudes et capacités de nature psychologique, il existe un sentiment de peur de l'échec en cas d'engagement. Cette peur de l'échec provient de caractéristiques personnelles et / ou de la société, sans aucun doute, d'une qualité perçue inférieure des opportunités

D'un autre côté, avoir des opportunités est une condition de créativité et une composante essentielle du processus entrepreneurial. Des opportunités peuvent être créées à l'initiative de l'homme d'affaires ou apparaître à partir de son environnement.

Dans tous les cas, il y a une construction de la part de l’entrepreneur pour transformer l’idée d’opportunité en projet de création. Cette attitude des opportunités s’effectue de façon sélective : l’un la percevra alors que l’autre l’ignorera. L’attitude dépend aussi du potentiel de l’entrepreneur ou du candidat à la création d’entreprise. Selon qu’il estime disposer des aptitudes et compétences nécessaires à la création, il percevra davantage d’opportunités et les jugera souvent plus favorablement
Konsumenci seniorzy wobec innowacji produktowych
Authors: Olejniczak Tomasz
Published: May 2023

Starzenie się ludności postępuje, a skutki wywołane tym procesem stają się coraz bardziej dostrzegalne. Wraz z procesem starzenia się człowieka zachodzą w jego organizmie ogólne zmiany o charakterze fizycznym, fizjologicznym i psychicznym, modyfikując zachowania rynkowe. W sferze ekonomicznej zwiększająca się liczba seniorów wpływa na strukturę produkcji, podziału, wymiany i konsumpcji środków zaspokajających potrzeby ludzkie. Zachowania konsumentów seniorów w ostatnich latach stały się przedmiotem badań wielu dziedzin nauki; kwerenda bibliograficzna wykazała jednak, że obszar innowacyjności zachowań ludzi starszych nie cieszył się zainteresowaniem badaczy. Zapewne wynika to z często prezentowanego w mediach stereotypu ludzi starszych jako niedostosowanych do zmian otoczenia, zamkniętych na nowości rynkowe. Jako główny cel monografii przyjęto określenie determinant zakupu i akceptacji przez konsumentów seniorów innowacji produktowych wybranych kategorii dóbr materialnych FMCG (fast-moving consumer goods). Przeprowadzono trzyetapową sekwencję badań wśród osób po 60. roku życia na terenie Wielkopolski, wykorzystując metodę wywiadu osobistego. Efektem analiz jest określenie modelu postaw seniorów wobec innowacji oraz zbudowanie modelu zakupu i akceptacji przez seniorów innowacji produktowych na rynku FMCG. Dodatkowo zaproponowano segmentację konsumentów seniorów według kryterium zdefiniowanej innowacyjności konsumenckiej, która pozwoliła na wyodrębnienie pięciu typów: niechętnych konserwatywnych, zorientowanych tradycjonalistów, aspirujących wycofanych, nieświadomych praktycznych oraz racjonalnych innowatorów. Zgromadzony materiał teoretyczno-empiryczny może znaleźć zastosowanie w procesie zarządzania portfelem produktów zarówno na etapie inicjowania i wprowadzania innowacji produktowych na rynek, jak i na etapie modyfikacji produktów już istniejących w celu uzyskania akceptacji konsumentów seniorów.
تداخل اللغة الإندونيسية مع اللغة العربية في محادثة الطلاب بمعهد نور الحكيم لومبوك الغربية/Indonesian interference on Arabic in the conversation of the students of Nurul Hakim's Islamic boarding school, West Lombok
Authors: Anwar M. Syahrul , Adama Habibia , Ahmad Bakri Mohammad Bkheet , Zuhdi Halimi , Fadhillah Friska
Published: May 2023

This study aims to study the forms of Indonesian language interferention in Arabic used by students in the madrasah environment who practice their knowledge of Arabic every day and aims to discuss the factors that influence language intervention and the impact of language intervention on students' conversations. This research is qualitative research using descriptive method. The data obtained in this study were through observation and interviews with students and teachers at one of the schools at the Nur Hakim's Islamic boarding school, West Lombok. The results showed that Arabic was used by students at the Nur Hakim's Islamic boarding school, West Lombok. It turns out that they are still very much influenced by their mother tongue, namely Indonesian. These interventions are spread over several aspects such as phonology, morphology, syntax, and lexicography. Teachers try to minimize various forms of language disorders by conducting conversational activities regularly, teaching Arabic grammar and asking students to memorize Arabic vocabulary.
The Analysis of Students’ School Burnout Level and Academic Achievement on The Science Management Subject
Authors: Masruroh Masruroh , Nawafilah Nur Qomariyah , Anggraini Erry
Published: May 2023

School burnout can be a vulnerable thing experienced by students during learning process. This study is purposed to describe the difference of students’ academic achievement in management science subject based on school burnout level. This study is quantitative descriptive study. Students’ school burnout level data was gathered using school burnout inventory using Google form questionnaire, while students’ academic achievement data was attained from students’ final score on management science subject. Data was taken from 83 respondents who were actively participate in management science subject. Data of students’ school burnout then was categorized into low and high level of school burnout. The academic achievement from each group of school burnout level then was compared and analyzed using t-test on R software. The result showed that 52% students have low school burnout level and the other 48% have high school burnout level. The average of students’ academic achievement from low and high levels school burnout group were 78.0 and 75.7 sequentially. The p-value generated from t-test was 0.1644, greater than 0.05. Thus, it can be concluded that there was no significant difference on students’ academic achievement between low and high level of school burnout group.
Aircraft icing mechanism analysis methods
Authors: Egorov A.V.
Published: May 2023

To ensure flight safety, it is important to know how the icing processes of the aircraft aerodynamic surfaces occur. The article provides a review of works related to the analysis of the aircraft icing mechanism. According to publications, existing approaches to the analysis of the icing mechanism are divided into three groups: experimental research and testing, numerical modeling, and machine learning of neural networks. It is shown that experiments and tests give the most accurate results, since they are carried out in natural or close to natural flight conditions. Object-oriented results are obtained from numerical simulations when the input data set is tied to a specific aircraft. A disadvantage of numerical simulation is noted — a long calculation time. Attention is drawn to the fact that at present, machine learning methods for neural networks are being developed and are beginning to be implemented. These methods show a short computation time and predict not only the shape and size of ice, but also allow assessing the danger of icing and ranking the factors affecting icing, according to the degree of their importance. The article reveals the relationship of these three areas of analysis of the icing mechanism.
Taekwondo training: Personality education
Authors:   The World Society of Taekwondo Culture, Kim Soo-Jung
Published: May 2023

In this study, what can the results of looking at the item of personality education from the perspective of taekwondo training bring? Literature studies were conducted based on previous studies and various data, and the results derived in this way were organized by category and the results were as follows. First, definition and value of Taekwondo and training. Second, the meaning of personality education: social needs. Third, the value of Taekwondo training: personality education. Since it is what a person thinks, speaks, and acts, the feeling or value that a person feels is the same as the value obtained through training and the value obtained through education.
The Relationship among Burnout, Moral Disengagement and Antisocial Behavior of High-school Taekwondo Athletes
Authors:   The World Society of Taekwondo Culture, Kim Su Yeon , Choi Yeon Ho
Published: May 2023

The purpose of this study was to investigate causal relationship among burnout, moral disengagement and antisocial behavior of high-school Taekwondo athletes. For this purpose, a sample of 300 drawn out of the high-school Taekwondo athletes from NAVER platform. Data acquired from 7 high-school Taekwondo athletes were excluded due to inconsistency in their responses. Therefore, the data of 393 atheltes (male 203, female 90) was used for a final analysis. For the collected data, descriptive statistics, confirmatory factor analysis, correlation analysis, and structural equation analysis were performed using jamovi 1.1 and AMOS 23.0 programs. The following results. First, the burnout of high-school Taekwondo athletes has a positive(+) effect on moral disengagement. second, the burnout of high-school Taekwondo athletes has a positive(+) effect on antisocial behavior. Third, the moral disengagement of high-school Taekwondo athletes has a positive(+) effect on antisocial behavior.
Sverdlovsk railway in 1941-1945: contribution to evacuation
Authors: Speranskiy A.
Published: May 2023

The paper analyses the work of the Sverdlovsk railway divided during the Great Patriotic War into two main lines - the Perm and the Sverdlovsk lines (before 1943 - named after L.M. Kaganovich) to ensure the evacuation of industrial enterprises and population from western territories of the USSR to the eastern regions. The paper also shows the process of conversion of the railway economy to correspond to war requirements and needs and describes measures aimed at overcoming difficulties, such as staff reduction, a poor repair base, lack of locomotives and fuel for them, inconsistency of dispatching services. Particular emphasis is placed on the occurrence of “traffic jams” associated with an increase in the intensity of rail traffic and loading-to-unloading problems that directly affected the effectiveness of the rolling stock.

The paper reveals weaknesses in organization and implementation of transporting civilians to the rear areas. The author found that systematic train schedule delays, inconsistency in the actions of evacuation and railway services generated a lot of everyday problems, e.g. low comfort, poor nutrition, spread of infectious and cold-related diseases and, as a consequence, a high percentage of mortality among evacuated passengers.

Throughout the whole war period, the Soviet authorities intentionally corrected negative moments in the functioning of railway lines. As a result of the adoption of a number of government resolutions followed by the corresponding efficient actions, the “great migration to the East” of industry and a significant part of population from areas subjected to the Nazi invasion was successful. The Sverdlovsk railway fulfilled its tasks with honour making a significant contribution to the evacuation and creation of a powerful military-industrial complex in the Urals.
Materials on the economic structure of the population of the Luza region (from the report of the Luza ethnographic expedition of 1959) (publication of I.L. Zherebtsov, V.A. Sablin, L.Ya. Kaneva)
Authors: Lashuk L.
Published: May 2023

The paper includes a previously unpublished fragment from the scientific report of the Luza ethnographic team of the Komi Branch of the Academy of Sciences of the USSR of 1959 devoted to the economic structure of the population of the Luza region (Komi Republic, Russia).
A Case Report about the Management of Hereditary Angioedema with Normal Complement Levels during Pregnancy
Authors: Pinto Ana Raquel , Machado Cunha Inês , Carolino Fabrícia
Published: May 2023

N/a.
Fontes para uma análise da pintura paulista do século XVII ao XIX: os pintores, as obras e os restauros
Authors:   Universidade de São Paulo, Salomão Myriam
Published: May 2023

A pintura paulista produzida entre o final do século XVII e metade do XIX carece de estudos gerais quanto à autoria, cronologia, iconografia, inventário das obras e nos modelos que circularam e influenciaram essa produção.
Pavilhões experimentais como laboratório de projeto e fabricação digital
Authors: Silva Felipe Tavares da , Celani Maria Gabriela Caffarena , Checcucci Érica de Sousa
Published: May 2023

O objetivo deste trabalho é apresentar e discutir a construção de pequenos pavilhões como oportunidade de experimentação no processo digital de projeto, modelagem, fabricação digital (FD) e montagem de formas complexas arquitetônicas, baseadas em oficinas realizadas entre os anos de 2017 e 2019 em duas faculdades de Arquitetura em diferentes universidades do Brasil. O Design Science foi o principal método científico adotado na pesquisa, sendo a pesquisa de campo exploratória experimental utilizada nas diferentes oficinas para produção dos objetos e validação do processo. Os pavilhões consistiram em estruturas de cascas funiculares com função de promover sombra, e suas formas foram obtidas por algoritmo generativo paramétrico. Aos participantes das oficinas de modelagem foi disponibilizado um código do Grasshopper para que eles o manipulassem com fins de projetar suas próprias versões do pavilhão. Foram materializados, entre maquetes em escala reduzida e protótipos em escala natural, quatro diferentes instâncias de pavilhões modeladas e fabricadas digitalmente. Com estas experiências evidenciaram-se diferentes potencialidades didáticas que a modelagem paramétrica (MP), a FD e a montagem de pavilhões podem oferecer. Dentre estas, a reflexão sobre processos de concepção de uma envoltória arquitetônica e as suas implicações na construtibilidade, a experimentação da MP no projeto da forma e a possibilidade de vivenciar todo o ciclo de projeto e construção de um objeto arquitetônico durante o curso de graduação. Apresentando as experiências vivenciadas e discutindo sobre suas vicissitudes e as dificuldades encontradas, este trabalho espera contribuir com a discussão sobre MP e FD de envoltórias arquitetônicas de formas complexas.
Processo paramétrico para o custo unitário geométrico
Authors: Mariano Pedro Oscar Pizzetti , Vaz Carlos Eduardo Verzola
Published: May 2023

Esse artigo faz parte de uma pesquisa que visa interpretar o papel do arquiteto em um futuro em que os processos autônomos sejam colaboradores constantes nas atividades de projeto, e, para isso, pretende-se desenvolver uma ferramenta paramétrica baseada em múltiplos critérios de desempenho. Assim, a investigação pretende construir, testar e validar um processo de projeto capaz de estimar o custo de uma construção na fase inicial de projeto por meio do Custo Unitário Geométrico (CUG). O artigo também visa validar e possibilitar que o método seja utilizado como um instrumento de coleta de dados nas primeiras fases do processo de projeto. Para isso, o corpo teórico foi estudado e aplicado em uma programação visual, de modo a ser possível calcular automaticamente o Custo Unitário Geométrico a partir de uma composição de formas simplificadas. Após, a construção do processo digital passou por uma sequência de testes envolvendo composições geométricas e comparando seus resultados com os de outro método comumente aceito, o Custo Unitário Básico (CUB). Como resultado, observou-se que os valores encontrados com o método do CUG apresentam constante variação, não estando vinculadas diretamente à área analisada. Assim, conclui-se que foi possível comprovar o uso do CUG, pois a experimentação permite identificar diferentes custos para áreas projetadas semelhantes. O desenvolvimento do processo também trouxe a discussão da utilização do método e do processo que podem auxiliar profissionais a potencializar sua interpretação do custo do projeto nas primeiras composições e, também, a possibilidade de ser utilizado como instrumento de ensino, apresentando as consequências de custo de diferentes formas.
EPIDEMIOLOGIA DA DIABETES MELLITUS NO BRASIL DE 2018 A 2022
Authors: Santos Segundo Ademir Esperidião , Da Silva Pin Lucio Fernando , Moreira Neves dos Santos Elvins Eugênio , Rangearo Peres Carlos Alberto
Published: May 2023

INTRODUÇÃO: Diabetes Mellitus (DM) é uma síndrome metabólica de origem múltipla, decorrente da falta de insulina e/ou da incapacidade e/ou falta de insulina exercer adequadamente seus efeitos, caracterizando altas taxa de açúcar no sangue (hiperglicemia) de forma permanente. O DM possui dois tipos: tipo 1 (DM1) e tipo 2 (DM2) Essa doença pode apresentar diversas complicações, dentre elas, a insuficiência renal, amputação de membros inferiores, cegueira e doença cardiovascular. OBJETIVOS: Realizar a arguição do perfil  epidemiológico desta patologia no Brasil, entre 2017 e 2022 METODOLOGIA: Estudo epidemiológico, descritivo, realizado por meio da coleta de dados anuais referentes ao período entre 2018 até 2022, no Brasil, disponibilizado pelo Sistema de Informações Hospitalares (SIH) RESULTADOS: Foram registrados 659.639 casos confirmados por DM sendo homens o sexo mais atingido e idosos o grupo etário com maior prevalência. Região com mais casos de DM, mais óbitos e maior Taxa de Mortalidade foi o Sudeste. Nos 5 anos foram registrados 29.280 óbitos. CONCLUSÃO: Diabetes Mellitus apresenta muitas nuances e particularidades desde os fatores que a desencadeiam e os desencadeados por essa patologia. Por esse motivo o incentivo a melhores hábitos de vida (físicos e alimentares), além do diagnóstico e tratamento precoces são fundamentais para mitigação e erradicação da patologia no país
Estudo epidemiológico da Infecções do Trato Urinário no Tocantins de 2017 a 2021
Authors: Aires Magalhães Seixas Carlos Henrique A , Cavalcante Soares Gabriel José , Carvalho de Aguiar Guilherme Elias , Nader Ferreira Pedro Eduardo
Published: May 2023

Introdução: Transtorno do trato urinário é caracterizada pela presença de agente infeccioso na urina. Já a cistite é uma infecção e/ou inflamação da bexiga. Tanto Transtorno do Trato Urinário quanto a cistite caracterizam Infecção do Trato Urinário. O diagnóstico clínico é feito com base no raciocínio clínico e diagnóstico laboratorial. Objetivos: realizar uma arguição epidemiológica das internações por Infecções do Trato Urinário no Tocantins de 2017 a 2021 Metodologia: estudo epidemiológico descritivo, realizado por meio da coleta de dados anuais referentes ao período de 2017 a 2021, no estado do Tocantins (TO), disponibilizado pelo Sistema de Informações Hospitalares (SIH). Resultados: Nos 5 anos de análise foram registrados 1.495 casos. Adultos com 63,87% dos registros foi o grupo etário mais acometido, sendo que mulheres com 87,49% foi o sexo mais atingido. Capim dourado foi a região de saúde com mais notificações (34,51%). Conclusão: as Infecções do Trato Urinário têm suas peculiaridades o que dificulta seu tratamento, nesse viés políticas públicas e estratégias governamentais são precípuos

Palavras-chave: Cistite. Trato urinário. Epidemiologia. Transtorno
Prognosis of Adverse Outcomes in the Research of Coronary Blood Flow During Echocardiography
Authors: Kalinina E. S. , Zagatina A. V. , Sayganov S. A.
Published: May 2023

Aim. The goals of this research are to define the frequency of the coronary arteries visualization possibilities depending on various factors at routine echocardiography and estimate to the relation of coronary flow ultrasound parameters to prognosis of the adverse outcomes in the subsequent year.

Material and methods. The study comprises 581 consecutive patients. All patients performed echocardiography following standard method with an additional tab called «Coronary» which was set to visualize coronary arteries. Also all patients underwent a standard examination and debriefing of anamnesis. Observation of patients was the next year after echocardiography. The end points in the study – death from any cause, myocardial infarction (MI), death/ MI, myocardial revascularization operations - stenting and aortocoronary bypass (CABG). The analysis of clinical outcomes was carried out using the study of medical history and outpatient cards, interviewing patients at the time of admission, as well as the method of telephone survey of patients or their next of kin. ROC analysis as well as subgroup survival analysis using the Kaplan-Meier method was performed.

Results. The possibility to visualize the segments of coronary arteries and to estimate the coronary flow was in 91% of cases, or 526 patients. Women predominated among the patients (59.7% versus 40.3%). During follow-up, 73 patients recorded endpoints: 23 people died, 4 patients suffered non-fatal MI. 24 patients underwent CABG, 22 patients – myocardial revascularization. Depending on the quartile distribution by body mass index and age, a significant difference in visualization was not identified. Mortality was observed significantly more frequent when the flow velocity in the left coronary artery/proximal left artery descending/circumflex artery was higher than 64 cm/s. Flow velocity in left coronary artery /proximal left artery descending 64 cm/s was the cut-off value predicting MI with 100% sensitivity, 73,4% specificity (p<0.0001). Conclusion. Coronary flow velocity parameters provide long-term prognostic value that can be used to identify individuals with high risk of developing adverse cardiovascular events. Key words: coronary flow velocity, echocardiography, coronary artery, adverse events>˂0.0001).

Conclusion. Coronary flow velocity parameters provide long-term prognostic value that can be used to identify individuals with high risk of developing adverse cardiovascular events.
Vasotoxic Effects of Anticancer Therapy: a Review of Current Data
Authors: Vasyuk Yu. A. , Shupenina E. Y. , Nosova A. G. , Novosel E. O. , Vyzhigin D. A.
Published: May 2023

Cardiovascular and oncological diseases are the leading causes of adult death in the world. Despite proven efficacy, anticancer drugs can cause severe cardiovascular complications. Recently, data have appeared on the possible vasotoxic effects of chemotherapy drugs, which can manifest themselves as the progression of arterial hypertension and atherosclerosis, the development of myocardial ischemia and acute coronary syndrome, the formation of venous and arterial thrombosis. The key mechanism for the development of vasotoxicity is endothelial dysfunction, and anticancer drugs can also affect the processes of thrombosis. The review presents the results of 12 selected observational retro- and prospective studies involving cancer patients receiving presumably vasotoxic therapy. Data on the frequency of occurrence and possibilities for the prevention of vasotoxicity are presented.
Evolution of CHA2DS2-VASc Score for Predicting Risk of Stroke Development in Patients with Atrial Fibrillation
Authors: Rubanenko A. O.
Published: May 2023

Atrial fibrillation (AF) is associated with dramatic increasing of stroke risk. Development of this serious complication is accompanied by high mortality and disability. Nowadays we know many different scores that predict stroke risk,butthe most popular is CHA2DS2-VASc risk score. At the same time, this score does not have high predictive accuracyand that is why a lot of modifications with inclusion/deletion of different indicators were introduced.

The aim of this review was to estimate the different modifications of CHADS2 и CHA2DS2-VASc scores in predicting stroke risk in patients with AF. In this review R2CHADS2, CHA2DS2-VASc-R, CHA2DS2-VA, mCHA2DS2-VASc and CHA2DS2-VAK scores are evaluated with the use of C-statistics and net reclassification index compared to the original CHA2DS2-VASc score. The search of studies was performed according to PubMed database (https://pubmed.ncbi.nlm.nih.gov/) from 2011 until 2021 years. In this review were included studies written in English with free full text. Literature reviews, books, abstracts books, studies performed on less than 900 patients and studies without C-statistics data available were excluded from this review. Despite of the numerous attempts to improve the quality of CHA2DS2-VASc score, existing modifications nowadays could not become more popular in clinical practice. At the same time, developing of the new score systems, that will have better predictive values in stroke prognosis than CHA2DS2-VASc score, is still an actual problem in modern cardiology.
Antithrombotic Therapy in Patients with Paroxysmal Atrial Fibrillation after Catheter Treatment
Authors: Eshmatov O. R. , Khlynin M. S. , Batalov R. E. , Archakov E. A. , Kisteneva I. V.
Published: May 2023

Aim. To study the efficacy and safety of antithrombotic therapy in patients with paroxysmal atrial fibrillation (AF) after catheter treatment during 36 months of follow-up.

Material and methods. The retrospective observational study included 592 patients (283 men) who underwent catheter treatment of AF, aged 26 to 86 years (median age was 61.0 [55; 67]) with paroxysmal AF, treated in cardiac arrhythmias department of the Institute of Cardiology of Tomsk National Research Medical Center from 01.01.2017 to 31.12.2019. All patients were retrospectively divided into 2 groups: the first group consisted of patients with effective AF ablation, the second - with ineffective AF ablation. During follow-up after 12, 24 and 36 months, patients' complaints, documented arrhythmia recurrences, adherence to the prescribed treatment, and adverse clinical events were taken into account.

Results. In patients with paroxysmal AF, the effectiveness of catheter treatment was 73.1% after 12 months of follow-up, 69.3% – after 24 months, 71.6% – after 36 months. The analysis of our data showed that during the follow-up period of 36 months, the incidence of ischemic stroke against the background of anticoagulant therapy and effective catheter treatment of paroxysmal AF was significantly lower than in patients with unsuccessful ablation (0.3% (n=1) and 3.7% (n=4), respectively), even despite the fact that not all patients from the first group received prescribed medication.

Conclusion. The use of anticoagulant therapy in patients with paroxysmal AF after interventional treatment is safe, since the invasive strategy in combination with anticoagulant therapy does not increase the risk of major and minor bleeding, and in the case of effective intervention allows statistically significantly reduce the risk of ischemic stroke and almost completely eliminate the likelihood of other thromboemolic complications.
sVCAM-1 as a Marker of Endothelial Dysfunction associated with Severe Course of a Novel Coronavirus Infection (COVID-19)
Authors: Podzolkov V. I. , Pokrovskaya A. E. , Vanina D. D. , Shvedov I. I.
Published: May 2023

Aim. To study the association of the level of endothelial dysfunction marker sVCAM-1 with the severe course of COVID-19.

Material and methods. The study included 100 patients with COVID-19, who were divided into 3 groups depending on the degree of lung damage based on the results of computed tomography (CT): group CT 1 – 29 patients, group CT 2 – 61 patients and the group CT 3 – 10 patients. In addition to the standard examination performed for coronavirus infection, all patients underwent carotid Doppler ultrasound, analysis of arterial stiffness indices (CAVI, ABI) using the VaSera device, and evaluation of the plasma sVCAM-1 concentration by ELISA.

Results. The plasma sVCAM-1 concentration was significantly higher in the groups of patients with moderately severe (CT 2) and severe (CT 3) lung lesions than in patients with mild lesions (CT 1). In the general group of patients significant correlations were found between the plasma sVCAM-1 concentration and the level of oxygen saturation (r=-0.39, p=0.032), hospital length of stay (r=0.24, p=0.026), values of C-reactive protein (r=0.25, p=0.042), ferritin (r=0.38, p=0.021), LDH (r=0.52, p=0.015) , as well as the percentage of pulmonary involvement according to CT data at admission (r=0.41, p=0.019) and on the day of discharge (r=0.35, p=0.022). According to multivariate regression analysis, sVCAM-1 does not depend upon gender, age, body mass index (BMI), the presence of type 2 diabetes mellitus (T2DM) and hypertension, and is a marker associated with cytokine storm progression, intermediate negative dynamics according to CT data, and need for respiratory support. The presence of type 2 diabetes, as well as elevated sVCAM-1 concentrations, is associated with an increased risk of high-dose glucocorticosteroid therapy. The threshold levels of this marker were calculated for each of the above events. We revealed a correlation between the sVCAM-1 concentration and the carotid intimal medial thickness in the general group of patients (r=0.25, p=0.036).

Conclusion. An increase in the plasma sVCAM-1 concentration reflects the progression of endothelial dysfunction, one of the key factors in the pathogenesis of COVID-19. The latter necessitates the need for endothelium protective therapy for these patients. The evaluation of sVCAM-1 in blood plasma is a promising diagnostic technique aimed at predicting the risk of a severe course of COVID-19 and its long-term health hazards.
Secondary Prevention and Quality of Life of Patients with Stable Coronary Heart Disease
Authors: Zharkova E. D. , Lukina Yu. V. , Kutishenko N. P. , Huseynova E. T. , Zolotareva N. P. , Martsevich S. Yu. , Drapkina O. M.
Published: May 2023

Aim. To assess the quality of life of patients with stable coronary heart disease (CHD) initially and 12 months after drug and non-drug secondary prophylaxis according to clinical guidelines.

Material and methods. 73 patients (57 men, 16 women) with confirmed stable coronary artery disease were included in the study, of which 44 patients described a clinic for angina pectoris of functional class I-IV. The study included 2 patient visits: an initial treatment visit (V0) and a repeat visit after 12 months (V2). At both visits, blood pressure (BP), low-density lipoprotein cholesterol (LDL-c), quality of life (QL) were assessed using SAQ (Seattle Angina Questionnaire), drug therapy. Compliance with 5 basic principles of prevention was also assessed, which included: (1) healthy lifestyle (healthy lifestyle) (rejection of bad habits (smoking), moderate physical activity, lowcholesterol and low-carb diet); (2) normalization of body weight; (3) optimal drug therapy (the frequency of taking medications was evaluated using the original questionnaire); (4) achievement of target values of LDL-c in the entire group; (5) blood pressure in hypertensive patients. During V0, if necessary, drug therapy was adjusted in accordance with clinical recommendations. During V2, 57 patients (47 men and 10 women) were examined. The response was 80.8%.

Results. After 12 months of follow-up, a statistically significant improvement in exercise tolerance (p=0.003), angina stability index (p=0.045) and the frequency of stress angina attacks (p=0.003) was noted when assessing the median of QL indicators. After 12 months of follow-up, 59% of patients used optimal drug therapy, including 4 drugs according to clinical guidelines. A healthy lifestyle (regular physical activity and smoking cessation) was achieved in 20.4% after 12 months of follow-up, the target level of LDL-c ˂ 1.8 mmol/L was achieved in 44.5% of patients, and the target blood pressure was achieved in 74,6%. The achievement of all 5 principles of secondary prevention of coronary heart disease according to the results of the work carried out by the visit after 12 months of follow-up was revealed only in 7% of patients (4 patients), and the implementation of 4 principles of prevention was noted in a quarter of patients from the group (24.5%, n=14).

Conclusions. With drug and non-drug secondary prevention of coronary heart disease in patients with stable CHD after a year of follow-up, a statistically significant increase in QL indicators was noted due to increased exercise tolerance and a decrease in the frequency of angina attacks. Nevertheless, the basic principles of prevention were fully implemented only in 7% of patients.
Scientific and practical aspects of the use of pro-, pre- and synbiotics in the feeding of ruminants againts the background of research conducted in Ukraine
Authors:   Institute of Agriculture of the Carpathian region of National Academy of Agrarian Sciences of Ukraine, Grushevskogo str., 5, Obroshyn, Pustomytivsky district, Lviv region, 81115, Ukraine, Vovk Stakh , Polovyi Ivan ,   Institute of Agriculture of the Carpathian region of National Academy of Agrarian Sciences of Ukraine, Grushevskogo str., 5, Obroshyn, Pustomytivsky district, Lviv region, 81115, Ukraine, Petryshyn Myron ,   Institute of Agriculture of the Carpathian region of National Academy of Agrarian Sciences of Ukraine, Grushevskogo str., 5, Obroshyn, Pustomytivsky district, Lviv region, 81115, Ukraine, Sablik Piotr ,   Department of Ruminant Science, West Pomeranian University of Technology, Szczecin, Janickiego 29, 71-270 Szczecin, Poland, Vantukh Andrii ,   Lviv National Agrarian University, Volodymyra Welykogo str., 1, Dubljany, Zhovkva district, Lviv region, 80381, Ukraine, Januś Ewa ,   Department of Cattle Breeding and Genetic Resources Conservation, Laboratory for Organic Production of Food of Animal Origin, University of Life Sciences in Lublin, Akademicka 13, 20-950 Lublin, Poland
Published: May 2023

The review article provides up-to-date scientific information on the characteristics, classification and mechanisms of biological action of pro-, pre- and synbiotics in the digestive tract of ruminants. The literature sources of recent years on the influence of pro-, pre- and synbiotic supplements (when adding them to the diets of ruminants) on the metabolic processes in the body, intensity of growth, development and the quality of products obtained from domestic ruminant animals are systematized and analyzed. Emphasis is placed on the fact that the degree of metabolic and productive action of these diet supplements in ruminants is determined primarily by the qualitative composition, technology of production, method of storage and quantity added to fodder. It is noted that the main mechanism of pro-, pre- and synbiotics action when entering the digestive tract of ruminant animals is optimizing the composition of its microflora, strengthening the barrier functions of the rumen, reticulum, omasum, abomasum and intestine, as well as activation of interferon synthesis by blood leukocytes, stimulation of digestive functions and strengthening immune status. Also it is stated that the use of these fodder additives in the diet optimizes the quantitative and qualitative composition of the symbiotic microbiota of the digestive tract, has an immunostimulatory effect, activates metabolic processes and improves the productive qualities of ruminants.
Identification of single nucleotide polymorphism within bactencin-5 and bactencin-7 coding genes in association with milk production traits
Authors:   Department of Genetics, Faculty of Biotechnology and Animal Husbandry. West Pomeranian University of Technology in Szczecin, Piastow Avenue 45, 70-311 Szczecin, Poland, Hiller Sonia , Kowalewska Inga ,   Department of Genetics, Faculty of Biotechnology and Animal Husbandry. West Pomeranian University of Technology in Szczecin, Piastow Avenue 45, 70-311 Szczecin, Poland
Published: May 2023

Bactencins belong to the bovine cathelicidin family of proteins, and their role in the body is significant. The study analyzed the relationship between polymorphisms within the CATHL2 and CATHL3 genes encoding the Bac-5 and Bac-7 proteins. The study included a herd of Polish Holstein-Friesian cows of the black-and-white breed. Tests were conducted using the PCR-RFLP method with the introduction of the ACRS modification. The study showed that different genetic variants within the polymorphisms studied were significantly associated with selected parameters of milk performance, such as milk yield (P ≤ 0.01), fat (P ≤ 0.01), protein (P ≤ 0.01 and P ≤ 0.05) and lactose (P ≤ 0.01 and P ≤ 0.05) content and somatic cell count (P ≤ 0.01 and P ≤ 0.05).
GAMBARAN SPASIAL HUBUNGAN ANTARA FAKTOR LINGKUNGAN DAN EKONOMI DENGAN STUNTING BALITA DI PROVINSI NUSA TENGGARA TIMUR
Authors: Nashriyah Siti Fadhilatun , Makhful Martya Rahmaniati , Devi Yuli Puspita
Published: May 2023

Background: The President through Presidential Regulation Number 72 of 2021 is committed to accelerating the reduction of stunting in Indonesia. The stunting priority areas also continue to be increased from year to year. In Indonesia, East Nusa Tenggara Province is the province with the highest prevalence of stunting, namely 37.8% in 2021.

Objective: To find out the spatial picture and the correlation between environmental factors and economic factors with the prevalence of stunting in East Nusa Tenggara Province in 2021.

Methods: The research design is an ecological study with a spatial approach. This study uses secondary data in the form of reports issued by the Indonesian Ministry of Health (SSGI: Indonesian Nutritional Status Study) and the BKKBN (PK: Family Data Collection) in 2021 with district/city-level analysis units in East Nusa Tenggara Province. Data analysis used a correlation test and mapping was carried out using the QGIS 2.8.1 application.

Results: The prevalence of stunting in NTT Province tends to be high in the eastern part while the risk factors for stunting (unfavorable environment and economy) tend to be high in the western part. The correlation test showed that the correlation between the prevalence of stunting and the poor was 0.165 (p = 0.463); with inadequate latrines of 0.420 (p = 0.052); and with inadequate drinking water sources of 0.426 (p = 0.048).
Oyun Teorisi Perspektifinden Çatışma Yönetim Stratejilerinin Karşılıklı Etkileşimi ve Denetçilere Yönelik Bir Uygulama
Authors: AYDIN Gürbüz , KARABACAK Hakan
Published: May 2023

Bu çalışmada çatışma sürecinin etkileşimli doğası dikkate alarak karar alıcı tarafların çatışma yönetim stratejilerinin birlikte analiz edilmesi ve en uygun stratejilerin tespit edilmesi amaçlanmaktadır. Analiz ve modelleme aracı olarak oyun teorisi yaklaşımı kullanılmıştır. Analiz sürecinde öncelikle tarafların çatışma yönetim stratejileri eşleştirilmiş ve Karşılıklı İkili İlgi Modeli adı verilen yeni bir model ortaya konmuştur. Model kapsamında çatışma yönetim stratejileri, ilgili literatür dikkate alınarak rekabetçi veya işbirlikçi niteliklerine göre sınıflandırılmıştır. Taraflar arasındaki etkileşimler bağlamında, çatışma yönetim stratejileri oyun teorisinin temel oyun formlarıyla incelenmiş ve denge analizleri yapılarak kuramsal sonuçlara ulaşılmıştır. Bu kuramsal sonuçlar denetçilere yönelik ampirik bir araştırmayla ölçülmüştür. Modelin Mahkûmlar İkilemi oyunu kapsamında analizi tarafların rekabet ve işbirliği stratejilerini birlikte benimsedikleri Nash dengesinin varlığına ve işbirliği dengesinin sürdürülebilirliğine yönelik kuramsal sonuçları desteklemektedir. Modelin Tavuk oyunu kapsamında analizi, en az bir tarafın rekabetçi tutum benimsemediği dengenin varlığına ve rekabetin sürdürülebilir olmadığına yönelik kuramsal sonuçları desteklemektedir. Modelin Geyik Avı oyunu kapsamında analizi ise her iki tarafın işbirliği stratejini seçtikleri dengenin varlığına ve işbirliği tutumunun sürdürülebilir olduğuna yönelik kuramsal sonuçları desteklemektedir.
Türkiye’nin İklim Değişikliği ile Mücadele Serüveni: Akademik Yazın Üzerine Bir Araştırma
Authors: GÖÇOĞLU İpek Didem , NEGİZ Nilüfer , GÖÇOĞLU Volkan
Published: May 2023

Bu çalışma, Türkiye’de akademik yazında iklim değişikliğinin öne çıkan alt konularını ve akademik yazını oluşturan bu kaynakları, kaynaklardan türeyen ürünleri ve bu ürünlerin içeriklerini tespit etmeyi amaçlamaktadır. Bu bağlamda çalışmada, öncelikle, uluslararası çalışmalarda iklim değişikliğinin öne çıkan konuları ele alınmakta, daha sonra ise konunun Türkiye’deki arka planı sunulmaktadır. Araştırma kısmında ise; Türkiye’de iklim değişikliği konusunda yazılan doktora tezleri üzerine odaklanılarak bir içerik analizi gerçekleştirilmiştir. Çalışmanın öne çıkan sonuçlarına göre, gelecekte Türkiye’de üretilecek iklim değişikliği odaklı doktora tezlerinin özellikle sosyal bilimler alanında Kamu Yönetimi, Ekonomi, Uluslararası İlişkiler, Şehircilik ve Bölge Planlama odağında ve fen bilimleri alanında ise Meteoroloji, Ormancılık ve Orman Mühendisliği ve dahi Çevre Mühendisliği disiplinleri temelinde yönlendirilmesi gerekmektedir. Özellikle sosyal bilimciler tarafından üretilmesi ve karar vericilere katkı vermesi beklenen iklim değişikliğine ilişkin uygulama, strateji ve politika odaklı çalışmaların nicelik olarak azlığı dikkat çekicidir. Bu konuda söz konusu alanlarda doktora öğrencilerine danışmanlık yapan akademisyenlerin çabasına özellikle ihtiyaç olduğu düşünülmektedir.
Sağlık Hizmetleri Finansmanında Kullanıcı Katkılarına Yönelik Bir Araştırma
Authors: TOPÇUOĞLU Esra , ŞANTAŞ Fatih
Published: May 2023

Bu çalışma, araştırmanın yürütüldüğü tarih itibariyle son bir yıl içerisinde sağlık kurumlarından sağlık hizmeti almış kişilerin kullanıcı katkılarına ilişkin bilgi düzeyleri ve görüşlerinin belirlenmesi amacıyla yapılmıştır. Araştırmada veri toplama yöntemi olarak anket kullanılmıştır. Çalışmada amaçlı örnekleme yöntemi yoluyla toplam 670 kişiye ulaşılmıştır. Çalışmada analiz yöntemi olarak tanımlayıcı istatistik yöntemleri ve Ki-kare analizi kullanılmıştır. Araştırmada katılımcıların %15,4’ü uygulanmakta olan kullanıcı katkı miktarları hakkında bilgi sahibi olduğunu ifade ederken, %84,6’sı kullanıcı katkıları hakkında herhangi bir bilgilerinin olmadığını belirtmişlerdir. Katılımcıların %70,1’i eczaneye ödemiş oldukları kullanıcı katkısının belirli bir bölümünün sağlık kurumlarından almış oldukları hizmetin bedeli olduğunu bilmektedir. Katılımcıların %15,2’si kullanıcı katkısı alınmayacak haller, sağlık hizmetleri ve kişiler hakkında bilgilerinin olduğunu belirtmişlerdir. Bu bulgular sonucunda kullanıcı katkılarının daha etkili ve verimli uygulanabilmesi için kullanıcı katkılarına yönelik kişilerin bilgi düzeyini artırıcı çalışmalar yapılması gerektiği söylenebilir. Bu kapsamda sağlık hizmeti kullanıcılarında bilinç düzeyinin artması için ilgili kurumlar tarafından konuyu açık bir şekilde anlatan broşürler dağıtılabilir ve özellikle kullanıcı katkılarını anlatan kamu spotları yayınlanabilir.
Türkiye’de Fisher Hipotezinin Geçerliliğine İlişkin Ampirik Bir Analiz
Authors: PAZARCI Şevket , KAR Asim , ALTUNTAŞ Mehmet
Published: May 2023

Faiz oranı ile enflasyon oranı arasındaki ilişkiyi açıklamaya çalışan Fisher hipotezinin uzun yıllar boyunca ampirik literatürde incelendiği görülmektedir. Bu çalışma Türkiye'de Fisher hipotezinin geçerliliğini zaman serisi analiz yöntemlerini kullanarak incelemektedir. Literatürden farklı olarak ortalama fonlama maliyeti (AOFM), kredi ve mevduat faiz oranları aynı anda kullanılarak geniş perspektif ile konunun incelenmesi amaçlanmıştır. Bu amaçla, Türkiye için 2011:01-2021:08 dönemi arasındaki verilere Engle ve Granger eşbütünleşme analizi yapılmıştır. Seriler arasında eşbütünleşik ilişki bulunmasının ardından FMOLS (Fully Modified Ordinary Least Squares) eşbütünleşme tahmincisi kullanılarak hipotezin geçerliliği incelenmiştir. FMOLS analizi tahmin bulgularına göre, enflasyon oranının faiz oranı üzerinde istatistiki anlamlı etkiler yarattığı ve bu etkinin kredi ve mevduat faizlerinde farklılaştığı, kredi faizlerinde daha yüksek olduğu görülmektedir. Genel olarak ise en yüksek etkinin AOFM’de olduğu sonucuna ulaşılmıştır. Ayrıca Toda ve Yamamoto nedensellik analizi de yapılarak seriler arasındaki nedensellik ilişkileri incelenmiştir. Toda ve Yamamoto nedensellik analiz sonuçlarına göre enflasyon oranından çeşitli faiz oranlarına nedensellik ilişkisi tespit edilmektedir. Bu ilişkinin ihtiyaç kredisi ve AOFM’de çift yönlü olduğu bulgusuna ulaşılmıştır. Özetle, ampirik bulgular, Türkiye’de Fisher hipotezinin desteklendiğini göstermektedir.
NG2-positive pericytes regulate homeostatic maintenance of slow-type skeletal muscle with rapid myonuclear turnover
Authors: Tatsukawa Takamitsu , Kano Kohei , Nakajima Kei-ichi , Yazawa Takashi , Eguchi Ryoji , Kabara Maki , Horiuchi Kiwamu , Hayasaka Taiki , Matsuo Risa , Hasebe Naoyuki , Azuma Nobuyoshi , Kawabe Jun-ichi
Published: May 2023

Background
Skeletal muscle comprises almost 40% of the human body and is essential for movement, structural support and metabolic homeostasis. Size of multinuclear skeletal muscle is stably maintained under steady conditions with the sporadic fusion of newly produced myocytes to compensate for the muscular turnover caused by daily wear and tear. It is becoming clear that microvascular pericytes (PCs) exhibit myogenic activity. However, whether PCs act as myogenic stem cells for the homeostatic maintenance of skeletal muscles during adulthood remains uncertain.
Methods
We utilized PC-fused myofibers using PC-specific lineage tracing mouse (NG2-CreERT/Rosa-tdTomato) to observe whether muscle resident PCs have myogenic potential during daily life. Genetic PC deletion mouse model (NG2-CreERT/DTA) were used to test whether PC differentiate to myofibers for maintenance of muscle structure and function under homeostatic condition.
Results
Under steady breeding conditions, tdTomato-expressing PCs were infused into myofibers, and subsequently, PC-derived nuclei were incorporated into myofibers. Especially in type-I slow-type myofibers such as the soleus, tdTomato+ myofibers were already observed three days after PC labeling; their ratio reached a peak (approximately 80%) within one month and was maintained for more than one year. Consistently, the NG2+ PC-specific deletion induced muscular atrophy in a slow-type myofiber-specific manner under steady breeding conditions. The number of myonucleus per volume of each myofiber was constant during observation period.
Conclusions
These findings demonstrate that the turnover of myonuclei in slow-type myofibers is relatively fast, with PCs acting as myogenic stem cells—the suppliers of new myonuclei under steady conditions—and play a vital role in the homeostatic maintenance of slow-type muscles.