bluuebunny/crossref_metadata_2025 huggingface dataset:
Malnutrition prevalence according to GLIM and its feasibility in geriatric patients: a prospective cross-sectional study
Authors: Enge Maria , Peelen Frida Ostonen , Nielsen Rikke Lundsgaard , Beck Anne Marie , Olin Ann Ödlund , Cederholm Tommy , Boström Anne-Marie , Paur Ingvild
Published: January 2024

Purpose

In 2019, the Global Leadership Initiative on Malnutrition (GLIM) suggested a 2-step diagnostic format for malnutrition including screening and diagnosis. Prospective validation and feasibility studies, using the complete set of the five GLIM criteria, are needed. The aims of this study were to determine the prevalence of malnutrition, and investigate how the prevalence varied with mode of screening. Furthermore, we assessed the feasibility of GLIM in geriatric patients.

Methods

Consecutive patients from two acute geriatric wards were included. For screening risk of malnutrition, the Mini Nutritional Assessment-Short Form (MNA-SF) or Malnutrition Screening Tool (MST) were used. In accordance with GLIM, a combination of phenotypic and etiologic criteria were required for the diagnosis of malnutrition. Feasibility was determined based on % data completeness, and above 80% completeness was considered feasible.

Results

One hundred patients (mean age 82 years, 58% women) were included. After screening with MNA-SF malnutrition was confirmed by GLIM in 51%, as compared with 35% after screening with MST (p = 0.039). Corresponding prevalence was 58% with no prior screening. Using hand grip strength as a supportive measure for reduced muscle mass, 69% of the patients were malnourished. Feasibility varied between 70 and 100% for the different GLIM criteria, with calf circumference as a proxy for reduced muscle mass having the lowest feasibility.

Conclusion

In acute geriatric patients, the prevalence of malnutrition according to GLIM varied depending on the screening tool used. In this setting, GLIM appears feasible, besides for the criterion of reduced muscle mass.
A comparison of antimicrobial regimen outcomes and antibiogram development in microbial keratitis: a prospective cohort study in Alexandria, Egypt
Authors: Nayel Amira A. , Hamdy Noha A. , Massoud Tamer H. , Mohamed Nelly M.
Published: January 2024

Introduction

Antimicrobial resistance in microbial keratitis has not been previously explored in Alexandria. We aim to recommend effective therapies through identification of etiological agents, determination of antimicrobial susceptibilities, and comparing outcomes of empiric topical antimicrobials.

Methods

In this 2022 prospective cohort conducted in Alexandria Main University Hospital cornea clinic, antimicrobial susceptibilities of isolated microorganisms from corneal scrapings were detected and antibiograms were developed. Bacterial (BK), fungal (FK), or mixed fungal/bacterial keratitis (MFBK) patients on empiric regimens were compared for ulcer healing, time-to-epithelialization, best-corrected visual acuity, interventions, and complications.

Results

The prevalent microorganisms in 93 positive-cultures were coagulase-negative staphylococci (CoNS, 30.1%), Pseudomonas aeruginosa (14%), and Aspergillus spp. (12.9%). CoNS were susceptible to vancomycin (VAN, 100%) and moxifloxacin (MOX, 90.9%). Gram-negative bacteria showed more susceptibility to gatifloxacin (90.9%) than MOX (57.1%), and to gentamicin (GEN, 44.4%) than ceftazidime (CAZ, 11.8%). Methicillin-resistance reached 23.9% among Gram-positive bacteria. Fungi exhibited 10% resistance to voriconazole (VRC). Percentages of healed ulcers in 49 BK patients using GEN + VAN, CAZ + VAN and MOX were 85.7%, 44.4%, and 64.5%, respectively (p = 0.259). Their median time-to-epithelialization reached 21, 30, and 30 days, respectively (log-rank p = 0.020). In 51 FK patients, more ulcers (88.9%) healed with natamycin (NT) + VRC combination compared to VRC (39.1%) or NT (52.6%) (p = 0.036). Their median time-to-epithelialization was 65, 60, and 22 days, respectively (log-rank p < 0.001). The VRC group required more interventions (60.9%) than NT + VRC-treated group (11.1%) (p = 0.018). In 23 MFBK patients, none healed using NT + CAZ + VAN, while 50% healed using VRC + CAZ + VAN (p = 0.052). Regimens had comparable visual outcomes and complications.

Conclusion

Based on the higher detected susceptibility, we recommend empiric MOX in suspected Gram-positive BK, gatifloxacin in Gram-negative BK, and GEN + VAN in severe BK. Due to better outcomes, we recommend NT + VRC in severe FK.

Trial registration

ClinicalTrials.gov identifier, NCT05655689. Registered December 19, 2022– Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT05655689?cond=NCT05655689.&draw=2&rank=1
Influence of 8-weeks of supervised static stretching or resistance training of pectoral major muscles on maximal strength, muscle thickness and range of motion
Authors: Wohlann Tim , Warneke Konstantin , Kalder Vincent , Behm David G. , Schmidt Tobias , Schiemann Stephan
Published: January 2024

Objectives

Current research suggests static stretch-induced maximal strength increases and muscle hypertrophy with potential to substitute resistance-training routines. However, most studies investigated the plantar flexors. This study explored the effects of a static stretching program on maximal strength, hypertrophy and flexibility of the pectoralis major and compared the effects with those of traditional resistance training.

Methods

Eighty-one (81) active participants were allocated to either a static stretching, strength-training or control group. Pectoralis stretching was applied 15 min/day, 4 days per week for 8 weeks, while resistance training trained 3 days per week, 5 × 12 repetitions.

Results

There was an increase in all parameters (strength: p < 0.001, ƞ2 = 0.313, muscle thickness: p < 0.001, ƞ2 = 0.157–0.264, flexibility: p < 0.001, ƞ2 = 0.316) and a time*group interaction (strength: p = 0.001, ƞ2 = 0.154, muscle thickness: p = 0.008–0.001, ƞ2 = 0.117–0.173, flexibility: p < 0.001, ƞ2 = 0.267). Post-hoc testing showed no difference between both intervention groups regarding maximal strength and muscle thickness (p = 0.905–0.983, d = 0.036–0.087), while flexibility increased in the stretching group (p = 0.001, d = 0.789).

Conclusion

Stretching showed increases in maximal strength and hypertrophy, which were comparable with commonly used resistance training. Based on current literature, the influence of mechanical tension as the underlying mechanism is discussed. Furthermore, as equipment and comparatively long stretching durations are requested to induce meaningful strength increases in recreationally active participants, practical application seems limited to special circumstances.
Volume expansion mitigates Shiga toxin-producing E. coli-hemolytic uremic syndrome in children
Authors: Böckenhauer Johannes , Schild Raphael , Kemper Markus J. , Henne Thomas , Stein Marie V. , Oh Jun , Loos Sebastian
Published: January 2024

Background

Shiga toxin-producing E. coli-hemolytic uremic syndrome (STEC-HUS) is associated with high morbidity and relevant mortality. Previous small studies showed that volume expansion could improve the course and outcome of STEC-HUS. The aim of this single-center study was to evaluate the effect of volume expansion on the clinical course and outcome in STEC-HUS.

Methods

Data of pediatric patients with STEC-HUS were analyzed retrospectively. Course and outcome of patients treated with volume expansion (VE) from 2019 to 2022 (n = 38) were compared to historical controls (HC) from 2009 to 2018 (n = 111).

Results

Patients in the VE group had a significant relative median weight gain compared to HC (7.8% (3.4–11.3) vs. 1.2% (− 0.7–3.9), p < 0.0001) 48 h after admission. The need for dialysis was not reduced by VE (VE 21/38 (55.3%) vs. HC 64/111 (57.7%), p = 0.8). However, central nervous system involvement (impairment of consciousness, seizures, focal neurological deficits, and/or visual disturbances) was significantly reduced (VE 6/38 (15.8%) vs. HC 38/111 (34.2%), p = 0.039). None of the patients in the VE group died or developed chronic kidney disease (CKD) stage 5, whereas in the HC group, three patients died and three patients had CKD stage 5 at discharge.

Conclusions

This study suggests that volume expansion may be associated with the mitigation of the acute course of STEC-HUS, especially severe neurological involvement and the development of CKD. Prospective trials should lead to standardized protocols for volume expansion in children with STEC-HUS.

Graphical abstract
Holograms for seamless integration of remote students in the classroom
Authors: Dominguez-Dager Bessie , Gomez-Donoso Francisco , Roig-Vila Rosabel , Escalona Felix , Cazorla Miguel
Published: January 2024

The new global scenario imposed by the SARS-CoV-2 virus has given rise to an atypical and problematic situation in multiple spheres. In very little time, the abrupt change from face-to-face to remote has not only required a rapid widespread use of digital technology, but also a change in methodology and communicative interactions. In the field of education, teachers have had to interact in new environments, with the combined use of face-to-face and non-face-to-face teaching being a major challenge. This paper presents the design and implementation of a cyber presence system for educational environments using Microsoft’s HoloLens 2 Mixed Reality (MR) headset. A software tool is developed that improves teaching scenarios through communication in mixed environments. The tool enables teachers to integrate the students in the classroom in a common space with remote students connected by videoconference. Our system is not limited to education, however, as it can also be deployed in any setting that requires remote communication, such as companies and governmental institutions.
A focused review on laser- and energy-assisted drug delivery for nail disorders
Authors: Konisky Hailey , Klinger Raquel , Coe Lesley , Jaller Jose A. , Cohen Joel L. , Kobets Kseniya
Published: January 2024

The purpose of this review is to consolidate and summarize laser-assisted drug delivery (LADD) for nail diseases, particularly onychomycosis and psoriasis. A PubMed search was conducted in June 2023 using search terms (1) “laser assisted drug delivery” AND “nail,” (2) “laser” AND “nail,” and (3) “nail disorder” AND “laser treatment.” References of papers were also reviewed, yielding 15 papers for this review. Fractional ablative CO2 laser (FACL) and Er:YAG laser can be used for LADD of topical medications such as amorolfine, terbinafine, and tioconazole to treat onychomycosis. A fungal culture should be performed to determine the type of dermatophyte, which will help determine which topical will be most effective. Laser settings varied between studies, but overall LADD tended to be more effective than topical treatments alone. Laser-assisted photodynamic therapy (PDT) was also found to be effective in treating onychomycosis. For psoriatic nails, LADD was used to deliver calcipotriol-betamethasone dipropionate foam, tazarotene, triamcinolone, or methotrexate into the nail. Again, LADD was found to be significantly more effective than topical treatment alone. FACL was the only laser noted for use for LADD in both diseases. Laser-assisted drug delivery for nail disease is a newer approach for onychomycosis and nail psoriasis with several benefits and drawbacks. Dermatologists should discuss the option of LADD with their patients who have recalcitrant onychomycosis or nail psoriasis.
Analysis of the clinical efficacy of visualization of percutaneous endoscopic lumbar discectomy combined with annulus fibrosus suture in lumbar disc herniation
Authors: Xi Jintao , Wang Xiaozhen , Li Xugui , Wu Congjun , Zhang Tonghui , Lu Qilin
Published: January 2024

The objective of this study is to compare the clinical effectiveness of visualization of percutaneous endoscopic lumbar discectomy (VPELD) combined with annulus fibrosus suture technique and simple percutaneous endoscopic lumbar discectomy (PELD) technique in the treatment of lumbar disc herniation. A retrospective analysis was conducted on 106 cases of lumbar disc herniation treated with foraminoscopic technique at our hospital from January 2020 to February 2022. Among them, 33 cases were treated with VPELD combined with annulus fibrosus suture in group A, and 73 cases were treated with PELD in group B. The preoperative and postoperative visual analogue scale (VAS), functional index (Oswestry Disability Index, ODI), healing of the annulus fibrosus, intervertebral space height, and postoperative recurrence were recorded and compared between the two groups. All patients underwent preoperative and postoperative MRI examinations, and the average follow-up period was 12 ± 2 months. Both groups showed significant improvements in postoperative VAS and ODI scores compared to the preoperative scores (P < 0.05), with no statistically significant difference between the groups during the same period (P > 0.05). There was no significant decrease in intervertebral space between the two groups after surgery (P > 0.05). Group A showed significantly lower postoperative recurrence rate and better annulus fibrosus healing compared to group B (P < 0.05). The VPELD combined with annulus fibrosus suture technique is a safe, feasible, and effective procedure for the treatment of lumbar disc herniation. When the indications are strictly adhered to, this technique can effectively reduce the postoperative recurrence rate and reoperation rate. It offers satisfactory clinical efficacy and can be considered as an alternative treatment option for eligible patients.
Exotic B-Series and S-Series: Algebraic Structures and Order Conditions for Invariant Measure Sampling
Authors: Bronasco Eugen
Published: January 2024

B-Series and generalizations are a powerful tool for the analysis of numerical integrators. An extension named exotic aromatic B-Series was introduced to study the order conditions for sampling the invariant measure of ergodic SDEs. Introducing a new symmetry normalization coefficient, we analyze the algebraic structures related to exotic B-Series and S-Series. Precisely, we prove the relationship between the Grossman–Larson algebras over exotic and grafted forests and the corresponding duals to the Connes–Kreimer coalgebras and use it to study the natural composition laws on exotic S-Series. Applying this algebraic framework to the derivation of order conditions for a class of stochastic Runge–Kutta methods, we present a multiplicative property that ensures some order conditions to be satisfied automatically.
Elevated serum IL-2 and Th17/Treg imbalance are associated with gout
Authors: Zi Xiaoyu , Su Ronghui , Su Rui , Wang Hui , Li Baochen , Gao Chong , Li Xiaofeng , Wang Caihong
Published: January 2024

Gout is considered an auto-inflammatory disorder, and the immunological drivers have not been fully unraveled. This study compared the peripheral lymphocyte and CD4+T cell subsets, and cytokines in gout and healthy controls (HCs) to explore the contributions of T helper 17 (Th17) cells, T regulatory (Treg) cells and cytokines to the pathogenesis of gout. We enrolled 126 gout patients (53 early-onset gout with age of first presentation < 40 years, and 73 late-onset gout with age of first presentation ≥ 40 years) and 77 HCs. Percentage and absolute numbers of peripheral lymphocyte and CD4+T cell subpopulations in each group were detected by flow cytometry. The serum cytokine levels were determined by flow cytometric bead array. For circulating CD4+T cell subsets, Th17/Treg ratio was significantly higher in early-onset gout, late-onset gout and gout without tophus than HCs; Th17 cells were significantly elevated in early-onset gout and gout without tophus, while the percentage of Treg cells was significantly decreased in early-onset and late-onset gout. Additionally, gout patients had significantly higher cytokines levels (including IL-2, IL-4, IL-6, IL-10, IL-17, IFN-γ, and TNF-α) than HCs; IL-2 levels were positively correlated with Treg cells and negatively correlated with ESR. ROC analysis showed that disease duration, CRP and fibrinogen, had moderate predictive performances for tophus in gout (the AUCs were 0.753, 0.703 and 0.701, respectively). Our study suggests that early-onset and late-onset gout differ in Th17/Treg imbalance, which in early-onset gout is due to elevated Th17 cells and in late-onset gout is due to decreased Treg cells. And increased serum cytokine levels, especially IL-2, may play an essential role in that. Restoring Th17/Treg balance may be a crucial way to improve the prognosis of gout patients.
Assessment of bone turnover markers and DXA parameters to predict bone metastasis progression during zoledronate treatment: a single-center experience
Authors: D’Oronzo Stella , Cives Mauro , Lauricella Eleonora , Stucci Stefania , Centonza Antonella , Gentile Marica , Ostuni Carmela , Porta Camillo
Published: January 2024

Bone metastases (BM) are a serious cancer complication, potentially causing substantial morbidity. Among the clinical issues related to BM, there is the lack of specific tools for early diagnosis and prognosis. We explored whether combining bone turnover markers (BTM) with dual-energy X-ray absorptiometry (DXA) assessment could identify early BM progression and risk of skeletal-related events (SREs) during zoledronate treatment. Before the initiation of zoledronate (T0) and after six months of treatment (T1), serum levels of five BTM were measured, and patients (N = 47) underwent DXA evaluation. Standard radiological imaging was performed to assess bone tumor response to medical anti-cancer treatment. High tumor burden in bone correlated with higher serum CTX (p = 0.007) and NTX (p = 0.005) at baseline. Low concentrations of OPG at T0 predicted BM progression with a sensitivity and specificity of 63% and 77%, respectively, when a cutoff of 5.2 pmol/l was used; such a predictive meaning was stronger in patients with lytic BM (sensitivity: 88%, specificity: 80%; p = 0.0006). As for the risk of SREs, we observed an association between low baseline OC (p = 0.04) and OPG (p = 0.08) and the onset of any-time SREs, whereas an increase in OPG over time was associated with reduced risk of on-study events (p = 0.03). Moreover, a statistically significant correlation emerged between low baseline lumbar T-score and femur BMD and on-study SREs (p < 0.001 in both instances). These findings suggest that addition of DXA to BTM dosage could help stratifying the risk of SREs at the time of BM diagnosis but does not enhance our capability of detecting bone progression, during zoledronate treatment.
Density-dependent dinner: Wild boar overuse agricultural land at high densities
Authors: Augustsson Evelina , Kim Hyeyoung , Andrén Henrik , Graf Lukas , Kjellander Petter , Widgren Stefan , Månsson Johan , Malmsten Jonas , Thurfjell Henrik
Published: January 2024

The Swedish wild boar (Sus scrofa) population has increased rapidly over the last decades, resulting in conflicts with human activities. Particularly, the increase has been challenging for agriculture as wild boar cause damage on crops and grasslands. To predict under what conditions to expect damage and where to prioritize management actions, basic knowledge about wild boar habitat and space use is needed. In this study, we used data from 99 wild boar equipped with GPS-collars, collected over a large temporal scale and throughout their distributional range in southern Sweden. We investigated wild boar home range size and habitat use across gradients of habitat availability and population density. Functional response in habitat use was assessed by estimating the use and availability of agricultural land on individual level and then, on population-level evaluating how use changed with changing availability. Finally, a potential response in habitat use was evaluated in relation to population density, i.e., the interaction between availability and population density. Home range size was negatively related to population density for both male and female wild boar. Wild boar used agricultural land more intensively with increasing population density and when other habitat types were less available. Our findings show that wild boar spatial behavior is highly context dependent and may vary considerably due to landscape characteristics and local conditions. Wild boars tend to overuse agricultural land at high densities which has strong implications for wildlife management. It is therefore important to consider local conditions when predicting space and habitat use by wild boar. Overall, this study provided a better understanding of the drivers of wild boar distribution and space use in agro-forested mosaic landscapes and how this knowledge can improve management practices.
Investigation of Head Kinematics and Brain Strain Response During Soccer Heading Using a Custom-Fit Instrumented Mouthguard
Authors: Barnes-Wood M. , McCloskey H. , Connelly S. , Gilchrist M. D. , Annaidh A. Ni , Theobald P. S.
Published: January 2024

Association football, also known as soccer in some regions, is unique in encouraging its participants to intentionally use their head to gain a competitive advantage, including scoring a goal. Repetitive head impacts are now being increasingly linked to an inflated risk of developing long-term neurodegenerative disease. This study investigated the effect of heading passes from different distances, using head acceleration data and finite element modelling to estimate brain injury risk. Seven university-level participants wore a custom-fitted instrumented mouthguard to capture linear and angular acceleration-time data. They performed 10 headers within a laboratory environment, from a combination of short, medium, and long passes. Kinematic data was then used to calculate peak linear acceleration, peak angular velocity, and peak angular acceleration as well as two brain injury metrics: head injury criterion and rotational injury criterion. Six degrees of freedom acceleration-time data were also inputted into a widely accepted finite element brain model to estimate strain-response using mean peak strain and cumulative strain damage measure values. Five headers were considered to have a 25% concussion risk. Mean peak linear acceleration equalled 26 ± 7.9 g, mean peak angular velocity 7.20 ± 2.18 rad/s, mean peak angular acceleration 1730 ± 611 rad/s2, and 95th percentile mean peak strain 0.0962 ± 0.252. Some of these data were similar to brain injury metrics reported from American football, which supports the need for further investigation into soccer heading.
Motivations for personal recordkeeping practices: the roles of personal factors, recordkeeping literacy and the affordances of records
Authors: Frings-Hessami Viviane
Published: January 2024

Why do individuals create and keep records? Little research has been done into the factors that motivate individuals to make records. This article uses the example of the personal records created by Bangladeshi rural women who participated in a development project to investigate the roles that personal choices and external influences play in the development of recordkeeping practices. By conducting interviews with participants after the end of the project, the author obtained some insights into the factors that encouraged them to create records during the project and the reasons why they continued or stopped doing it after the end of the project and about the role played by external actors, in particular local staff from non-governmental organisations, in influencing their recordkeeping practices. The author shows that the participants started creating and keeping records when they understood the importance that these records could have for them in the future and that the women who persevered with personal recordkeeping practices were those who were more educated and more information literate. On the other hand, the participants who wrote down information because they were encouraged to do so stopped doing it when the regular information flow ended, and they were no longer encouraged to capture information. The author argues that the factors that encourage individuals to create and keep records differ depending on the affordances that the records provide to them. Whereas external actors can play an important role in motivating people to keep records as evidence, for records that are kept for their informational content, personal motivations and recordkeeping literacy skills play a determinant role.
Clinical impact of delaying initiation of adjuvant chemotherapy in patients with early triple negative breast cancer
Authors: Hatzipanagiotou Maria Eleni , Pigerl Miriam , Gerken Michael , Räpple Sophie , Zeltner Verena , Hetterich Madeleine , Ugocsai Peter , Inwald Elisabeth Christine , Klinkhammer-Schalke Monika , Ortmann Olaf , Seitz Stephan
Published: January 2024

Purpose

The optimal time to initiation of adjuvant chemotherapy (TTAC) for triple negative breast cancer (TNBC) patients is unclear. This study evaluates the association between TTAC and survival in TNBC patients.

Methods

We conducted a retrospective study using data from a cohort of TNBC patients diagnosed between January 1, 2010 to December 31, 2018, registered in the Tumor Centre Regensburg was conducted. Data included demographics, pathology, treatment, recurrence and survival. TTAC was defined as days from primary surgery to first dose of adjuvant chemotherapy. The Kaplan–Meier method was used to evaluate impact of TTAC on overall survival (OS) and 5-year OS.

Results

A total of 245 TNBC patients treated with adjuvant chemotherapy and valid TTAC data were included. Median TTAC was 29 days. The group receiving systemic therapy within 22 to 28 days after surgery had the most favorable outcome, with median OS of 10.2 years. Groups receiving systemic therapy between 29–35 days, 36–42 days, and more than 6 weeks after surgery had significantly decreased median survival, with median OS of 8.3 years, 7.8 years, and 6.9 years, respectively. Patients receiving therapy between 22–28 days had significantly better survival compared to those receiving therapy between 29–35 days (p = 0.043), and patients receiving therapy after 22–28 days also demonstrated significantly better survival compared to those receiving therapy after more than 43 days (p = 0.033).

Conclusion

Timing of adjuvant systemic therapy can influence OS in TNBC patients. Efforts should be made to avoid unnecessary delays in administering chemotherapy to ensure timely initiation of systemic therapy and optimize patient outcomes.
Suspension, Entailment, and Presupposition
Authors: Rosa Luis
Published: January 2024

The paper is concerned with the rational requirements for suspended judgment, or what suspending judgment about a question rationally commits one to. It shows that two purported rational requirements for suspended judgment cannot both be true at the same time, at least when the entailment relation between questions is understood a certain way. The first one says that one is rationally required to suspend judgment about those questions that are entailed by the questions that one already suspends judgment about. The second one says that one is rationally required to believe the presuppositions of the questions one suspends judgment about. Two plausible solutions to the problem are discussed. One of them explicates the relation of entailment between questions in an alternative manner, and the other one rejects the presupposition requirement. Either way, a closure requirement for suspended judgment can be maintained which is analogous to the closure requirement for belief. Whereas belief is ideally closed under entailment between propositions, suspended judgment is ideally closed under entailment between questions.
Interspecific competitive interactions affect body size and oxidative status of two nonnative salmonid species
Authors: Parolini Marco , Iacobuzio Rocco , Bassano Bruno , Pennati Roberta
Published: January 2024

In fish, interspecific interactions between nonnative and other sympatric species are considered determinants in shaping species assemblages. Such interactions can also arise between nonnative fish species only, including salmonids such as the brown trout (Salmo trutta, Linnaeus, 1758) and the rainbow trout (Oncorhynchus mykiss, Walbaum, 1792), returning contrasting outcomes. The present manipulative experiment was aimed at exploring the effect of interspecific competition on the body growth and the oxidative status of parr (2 + -year-old individuals) of the brown trout and the rainbow trout. Allopatric (intraspecific competition) and sympatric (interspecific competition) populations of these species were experimentally recreated in two wild streams. At the end of a 2-month-long experiment, changes in specific growth rate (SGR), oxidative status (i.e., levels of reactive oxygen species and activity of antioxidant enzymes such as superoxide dismutase — SOD, catalase — CAT and glutathione peroxidase — GPx) and oxidative damage (i.e., lipid peroxidation) were investigated in brown and rainbow trout individuals maintained in allopatric or sympatric populations. Sympatric interactions between rainbow and brown trout parr resulted in a significant decrease in SGR of brown trout individuals only. Moreover, an overall modulation of the oxidative status, in terms of an increase in ROS levels coupled with the activation of SOD and CAT activity, occurred in brown trout individuals under sympatric conditions. These findings might suggest that, under sympatric conditions, parr of the rainbow trout are more competitive than brown trout for food acquisition. However, this competition affected the antioxidant defenses of the brown trout only, probably because of reduced ingestion of dietary antioxidants or increased physical activity and aggressive behavior. Thus, interspecific interactions can induce physiological and phenotypic effects on parr of nonnative salmonids, with potential consequences on the establishment of populations of these species in freshwater ecosystems.
The Lifeworld of the Complex Care Hospital Doctor: A Complex Adaptive Phenomenological Study
Authors: Borghmans Felice , Laletas Stella , Newnham Harvey , Fernandes Venesser
Published: January 2024

The ever-increasing prevalence of chronic conditions over the last half century has gradually altered the demographic of patients admitted to acute care settings; environments traditionally associated with episodic care rather than chronic and complex healthcare. In consequence, the lifeworld of the hospital medical doctor often entails healthcare for a complex, multi-morbid, patient cohort. This paper examines the experience of providing complex healthcare in the pressurised and fast-paced acute care setting. Four medical doctors from two metropolitan health services were interviewed and their data were analysed using a combinatorial framework of phenomenology and complexity theory. The horizon of complex care revealed itself as dynamic, expansive, immersive, and relational, entailing a specialised kind of practice that is now common in acute care settings. Yet this practice has made inroads largely without heralding the unique nature and potential of its ground. Herein lies opportunity for complex care clinicians to expand notions of health and illness, and to shape research, practice, and system design, for a future in which care for health complexity is optimised, irrespective of care settings.
Cryogenic Resonant Amplifier for Electron-on-Helium Image Charge Readout
Authors: Belianchikov Mikhail , Kraus Jakob A. , Konstantinov Denis
Published: January 2024

An electron-on-helium qubit is a promising physical platform for quantum information technologies. Among all the “blueprints” for the qubit realization, a hybrid Rydberg-spin qubit seems to be a promising one toward quantum computing using electron spins. The main technological challenge on the way to such qubits is a detection of fA range image current induced by a Rydberg transition of a single electron. To address this problem, we aim to use a tank LC-circuit in conjunction with a high-impedance and low power dissipation cryogenic amplifier. Here, we report our progress toward realization of a resonant image current detector with a homemade cryogenic amplifier based on FHX13LG HEMT. We present a detailed characterization of the transistor at room and cryogenic temperatures, as well as details of the amplifier design and performance. At the power dissipation level of amplifier well below 100 μW, the measured voltage and current noise level are $$0.6~{\hbox {nV}}/\sqrt{\textrm{Hz}}$$

0.6

nV
/

Hz

and below 1.5 fA/$$\sqrt{\textrm{Hz}}$$

Hz

, respectively. Based on the actual image current measurements of the Rydberg transition in a many-electron system on liquid helium, we estimate an SNR = 8 with a measurement bandwidth 1 Hz for the detection of a single-electron transition, providing the noise level at the output is solely determined by the noise of the amplifier.
Development of a novel testing concept for combined characterisation of tensile and compressive properties
Authors: Bensing Timo , Moneke Martin
Published: January 2024

A novel material testing concept is developed in order to provide tensile and compressive properties within a single mechanical test. A new specimen geometry is designed for testing in a universal testing machine. Under tensile load, both a homogeneous tensile stress condition as well as a homogeneous compressive stress condition occur in the specimen. Measurements accompanying the experimental test with digital image correlation provide tensile and compressive Poisson’s ratio as well as tensile modulus. These properties are input parameters for subsequent finite element simulations. The compressive modulus is determined by iteratively adjusting finite element simulations in order to couple experimental and simulated results. For validating the concept, experimental tests are carried out on polyoxymethylene. While the tensile Poisson’s ratio of the new concept shows the best agreement with the reference value, the compressive modulus is approximately 15% higher. Further work should focus on an appropriate material model in order to reduce the deviation.
Economic benefits of climate-smart agricultural practices: empirical investigations and policy implications
Authors: Sang Xiance , Chen Chen , Hu Die , Rahut Dil Bahadur
Published: January 2024

Adopting climate-smart agricultural practices (CAPs) has the potential to mitigate the adverse effects of climate change and directly influence the well-being of households. Therefore, this research investigates the impact of CAP adoption intensity on household income, net farm income, and income diversity, using the 2020 China Rural Revitalization Survey data. We utilize the approach of two-stage residual inclusion (2SRI) to mitigate the endogeneity of CAP adoption intensity. The results show that CAP adoption intensity positively and significantly affects household income, net farm income, and income diversity. Heterogeneous analysis indicates that the impacts of CAP adoption intensity on household income increase across the selected quantiles, but the impacts on net farm income decrease across the same. In addition, CAP adoption intensity significantly improves income diversity only at the 20th quantile. Our findings suggest that enhancing farmers’ CAP adoption intensity improves rural household welfare.
Parametric reduced-order modeling for component-oriented treatment and localized nonlinear feature inclusion
Authors: Vlachas Konstantinos , Garland Anthony , Quinn D.Dane , Chatzi Eleni
Published: January 2024

We propose coupling a physics-based reduction framework with a suited response decomposition technique to derive a component-oriented reduction (COR) approach, which is suitable for assembly systems featuring localized nonlinearities. Dependencies on influencing parameters are injected into the reduced-order model (ROM), thus ensuring robustness and validity over a domain of parametric inputs, while capturing nonlinear effects. The implemented approach employs individual component modes to capture localized features while additionally relying on reduced modes of a global nature to approximate the system’s dynamics accurately. The global modes are derived from a linear monolithic system, defined as a result of a coordinate separation scheme, which permits the proposed COR-ROM to naturally couple the response between linear and nonlinear subdomains. The derived low-order representation utilizes a proper orthogonal decomposition projection and is additionally reinforced with the inclusion of a hyper-reduction technique to capture the underlying high-fidelity model response while providing accelerated computations. The resulting approach is exemplified in the synthetic case studies of a four-story shear frame with multiple nonlinear regions driven by hysteresis and a large-scale kingpin connection featuring plasticity.
Magnetic Reconnection at Planetary Bodies and Astrospheres
Authors: Gershman Daniel J. , Fuselier Stephen A. , Cohen Ian J. , Turner Drew L. , Liu Yi-Hsin , Chen Li-Jen , Phan Tai D. , Stawarz Julia E. , DiBraccio Gina A. , Masters Adam , Ebert Robert W. , Sun Weijie , Harada Yuki , Swisdak Marc
Published: January 2024

Magnetic reconnection is a fundamental mechanism for the transport of mass and energy in planetary magnetospheres and astrospheres. While the process of reconnection is itself ubiquitous across a multitude of systems, the techniques used for its analysis can vary across scientific disciplines. Here we frame the latest understanding of reconnection theory by missions such as NASA’s Magnetospheric Multiscale (MMS) mission for use throughout the solar system and beyond. We discuss how reconnection can couple magnetized obstacles to both sub- and super-magnetosonic upstream flows. In addition, we address the need to model sheath plasmas and field-line draping around an obstacle to accurately parameterize the possibility for reconnection to occur. We conclude with a discussion of how reconnection energy conversion rates scale throughout the solar system. The results presented are not only applicable to within our solar system but also to astrospheres and exoplanets, such as the first recently detected exoplanet magnetosphere of HAT-11-1b.
Aristotelian universals, strong immanence, and construction
Authors: Costa Damiano , Giordani Alessandro
Published: January 2024

The Aristotelian view of universals, according to which each universal generically depends for its existence on its instantiations, has recently come under attack by a series of ground-theoretic arguments. The last such arguments, presented by Raven, promises to offer several significant improvements over its predecessors, such as avoiding commitment to the transitivity of ground and offering new reasons for the metaphysical priority of universals over their instantiations. In this paper, we argue that Raven's argument does not effectively avoid said commitment and that Raven's new reasons fail. Moreover, we present a novel ground-theoretic interpretation of the Aristotelian view, referred to as strong immanence, and introduce a new argument against the Aristotelian view, intended to sidestep any commitment to the transitivity of ground.
Decoration of viscose fibers with silver nanoparticle-based titanium-organic framework for use in environmental applications
Authors: Rehan Mohamed , Montaser Ahmed S. , El-Shahat Mahmoud , Abdelhameed Reda M.
Published: January 2024

To effectively remove pharmaceuticals, nitroaromatic compounds, and dyes from wastewater, an efficient multifunctional material was created based on silver nanoparticles (Ag) and MIL-125-NH2 (MOF) immobilized on viscose fibers (VF) as a support substrate. Firstly, silver nanoparticles (Ag) were immobilized on the surface of viscose fibers (VF) via in situ synthesis using trisodium citrate (TSC) as a reducing agent to create (VF-Ag). Then, VF and VF-Ag were decorated with the titanium metal–organic framework MIL-125-NH2 (MOF) to create VF-MOF and VF-Ag-MOF. The influence of VF-Ag, VF-MOF, and VF-Ag-MOF on the sonocatalytic or sonophotocatalytic degradation of sulfa drugs was investigated. The results show that VF-Ag-MOF showed excellent sonocatalytic and sonophotocatalytic activity towards the degradation of sulfa drugs compared to VF-Ag and VF-MOF. Furthermore, sonophotodegradation showed a dramatic enhancement in the efficiency of degradation of sulfa drugs compared to sonodegradation. The sonophotodegradation degradation percentage of sulfanilamide, sulfadiazine, and sulfamethazine drugs in the presence of VF-Ag-MOF was 65, 90, and 95 after 45 min of ultrasonic and visible light irradiation. The catalytic activity of VF-Ag, VF-MOF, and VF-Ag-MOF was evaluated through the conversion of p-nitrophenol (4-NP) to p-aminophenol (4-AP). The results demonstrate that VF-Ag-MOF had the highest catalytic activity, followed by VF-Ag and VF-MOF. The conversion percentage of 4-NP to 4-AP was 69%. The catalytic or photocatalytic effects of VF-Ag, VF-MOF, and VF-Ag-MOF on the elimination of methylene blue (MB) dye were investigated. The results demonstrate that VF-Ag-MOF showed high efficiency in removing the MB dye through the reduction (65%) or photodegradation (71%) after 60 min. VF-Ag-MOF composites structure–activity relationships represent that doping within silver NPs enhanced the photocatalytic activity of MIL-125-NH2, which could be explained as follows: (i) Due to the formation of a Schottky barrier at the junction between MIL-125-NH2 and Ag NPs, the photogenerated electrons in the conduction band of MIL-125-NH2 were supposed to be quickly transferred to the valence band of the Ag NPs, and subsequently, the electrons were transferred to the conduction band of Ag NPs. This considerable electron transferring process, which is reported as Z scheme heterojunction, can efficiently suppress the recombination of electron/hole pairs in VF-Ag-MIL-125-NH2 composites. (ii) Sufficient separation between the photogenerated charge carriers (holes and electrons) and avoiding their recombination enhanced the photocatalytic activity of composites.
Copper toxicity on Eisenia fetida in a vineyard soil: a combined study with standard tests, genotoxicity assessment and gut metagenomic analysis
Authors: Marini Enrica , De Bernardi Arianna , Tagliabue Francesca , Casucci Cristiano , Tiano Luca , Marcheggiani Fabio , Vaccari Filippo , Taskin Eren , Puglisi Edoardo , Brunetti Gianluca , Vischetti Costantino
Published: January 2024

Copper (Cu) toxicity is a pressing concern for several soils, especially in organic viticulture. The objective of this work was to assess Cu toxicity on the non-target organism Eisenia fetida, employing both traditional and novel tools for early identification of Cu-induced damages. In addition to traditional tests like avoidance and reproductive toxicity experiments, other tests such as the single cell gel electrophoresis (SCGE) and gut microbiome analysis were evaluated to identify early and more sensitive pollution biomarkers. Four sub-lethal Cu concentrations were studied, and the results showed strong dose-dependent responses by the earthworm avoidance test and the exceeding of habitat threshold limit at the higher Cu doses. An inverse proportionality was observed between reproductive output and soil Cu concentration. Bioaccumulation was not detected in earthworms; soil concentrations of potentially bioavailable Cu were not affected by E. fetida presence or by time. On the contrary, the SCGE test revealed dose-dependent genotoxicity for the ‘tail length’ parameter already at the second day of Cu exposition. Gut microbiome analysis a modulation of microbial composition, with the most aboundant families being Pectobateriaceae, Comamonadaceae and Microscillaceae. Bacillaceae increased over time and showed adaptability to copper up to 165 mg/kg, while at the highest dose even the sensitive Acetobacteriaceae family was affected. The research provided new insights into the ecotoxicity of Cu sub-lethal doses highlighting both alterations at earthworms’ cellular level and changes in their gut microbiota.
Mental Health of Hong Kong University Students Under COVID-19: Protective Ecological Factors and Underlying Mechanism
Authors: Chai Wenyu , Shek Daniel T. L.
Published: January 2024

While the COVID-19 has brought severe challenges to university students’ mental health, there is inadequate research on the related protective factors from different ecological systems and the underlying mechanisms. Guided by the ecological systems theory and the positive youth development approach, this study investigated the associations between two protective factors in the ecological systems (i.e., positive family functioning in the microsystem and Chinese cultural beliefs of adversity in the macrosystem) and students’ mental health in Hong Kong higher education during the period of the pandemic, with resilience (i.e., an important positive youth development quality) proposed as a mediating factor. This study was based on data collected in a large-scale survey of 978 Hong Kong Chinese undergraduate students (mean age = 20.69 with 62.9% being female) in the summer of 2022. Validated measures were used to assess students’ mental health problems (anxiety and depression), the ecological protective factors (positive family functioning and Chinese cultural beliefs of adversity), and resilience. Structural equation modelling was conducted to examine the associations between ecological protective factors and mental health problems, as well as the mediating effects of resilience in the associations. Structural equation modelling revealed that both positive family functioning and Chinese cultural beliefs of adversity negatively predicted anxiety and depression, with resilience partially mediating all paths. The study contributes significantly to the understanding of different ecological protective factors in higher education students’ mental health and the mediating role of resilience. It also provides practical implications for intervention and prevention.
Traces of collisional and transtensional processes between the Carpathia and the European platform in the geoelectric image (NE Slovakia and SE Poland)
Authors: Bezák Vladimír , Ondrášová Lenka , Vozár Ján , Oryński Szymon , Madzin Jozef , Majcin Dušan , Klanica Radek , Bilčík Dušan
Published: January 2024

We present the latest magnetotelluric models on profiles in the northeastern part of Slovakia and the southeastern part of Poland. These models are focused on deciphering the tectonic structures at the contact of the Inner Carpathians with the European Platform in this area. For the Inner Carpathian block, we propose the term Carpathia. Profile SA-01 shows shallower structures and the parallel MT-05 profile shows deeper structures. These models are also correlated with the seismic profile CEL-05. All results are compatible and show an original subduction-collisional structure, which was later replaced by a transpressive-transtensional one. The most striking structures are thick highly conductive subhorizontal zones in the middle crust and a tectonically controlled deep vertical conductive structure—the Carpathian conductive zone. Other significant structures, which also appear in the seismic section, are back thrusting of Flysch Belt and the Klippen Belt basement (Penninic crust) uplift.