Chronic coronary syndromes without standard modifiable cardiovascular risk factors and outcomes: the CLARIFY registry
Authors: Roger Guillaume , Ducrocq Grégory , Mesnier Jules , Sayah Neila , Abtan Jérémie , Ferrari Roberto , Ford Ian , Fox Kim M , Tardif Jean-Claude , Tendera Michal , Feldman Laurent J , Elbez Yedid , Steg Philippe Gabriel ,   CLARIFY Investigators, Steg P G , Ferrari R , Ford I , Fox K M , Tardif J C , Tendera M , Sokn Fernando José , Reid Christopher , Lang Irene , Van den Branden Frank , César Luis Machado , Luqman Nazar , Goudev Assen , Dorian Paul , Hu Dayi , Widimsky Petr , Hassager Christian , Danchin Nicolas , Kääb Stefan , Vardas Panos , Sulaiman Kadhim J , Al Mahmeed Wael , Al Suwaidi Jassim , Al Rashdan Ibrahim , Abdulkader Fuad , Merkely Béla , Kaul Upendra , Daly Kieran , Tavazzi Luigi , Ferrari Roberto , Jang Yangsoo , Erglis Andrejs , Laucevičius Aleksandras , Jamaluddin Ahmad Nizar , Gamba Marco Alcocer , Tulevski Igor I , Stępińska Janina , Morais Jońo , Macarie Cezar , Oganov Rafael , Shalnova Svetlana , Al-Zaibag Muayed , Hou Mak Koon , Kamensky Assoc Gabriel , Fras Zlatko , Kanič Vojko , Naidoo Datshana Prakesh , Zamorano José Luis , Rickli Hans , Jaussi Andres , Sriratanasathavorn Assoc Charn , Kalra Paul , Lutai Mykhailo , Parkhomenko Oleksandr , Nguyen Lan Viet , Henry Ronald , Ahuad Guerrero A , Basara M , Belcastro F , Bertarini J A , Cazenave C , Dreycopp H , Egido J , Estrella J , Garofalo D , Giordano J , Lagioia H , Lago N , La Greca R , Lema L , Lopez Cabanillas N , Luquez H , Miller C , Prada E , Rodenas P , Schena R G , Suarez G , Tomatti A , Colquhoun D M , Conradie A , Cox S , Cross D , Fathi R , Fitzgerald B , Hamilton-Craig I , Holt G , Jayasinghe S R , Mai N , Moolman J , Motyer R A , Phillips K , Rafter A , Rahman A , Rainbird A , Scalia G , Taylor A , West P , Alford K , Amor R , Astridge P , Bastian B , Bates F , Doohan M M , Du Plooy J , Ford J C , Kanagaratnam L , Khoury V , Parkin R , Rogers J , Sceats G , Waldman A , Wang D , Wright S , Ardill J , Aylward P , Beltrame J F , Bradley J , Heddle W , Joseph M , Rajendran S , Varughese S , Brice E , Hockings B , Janssen J , Kozlowski A , O'Shea J , Tan J , Playford D A , Woollard K , Ajani A , Barron G , Better N , Carruthers T , Chan B , Chan R , Cotroneo J , Counsell J T , Eccleston D S , Forge B H R , Hamer A , Horrigan M , Jelinek V M J , Lew R , O'Donnell D , Panetta F , Sebastian M , Shetty P , Soward A , Srivastava P , Strathmore N F , Sylivris S , Szto G , Veth V , Yip T , Badr-Eslam R , Kleemann L , Steurer G , Mörz-Proszowski B , Auhser F , Teleky U , Sepp G , Beinhauer A , Kerö D , Lavicka C , Perger T , Hadjiivanov V , Feldner-Busztin M , Mika R , Filip W , Mahr A , Toplak J , Millauer M G , Haralambus P , Walcher K , Karner K H , Ziak E , Painsipp P , Frank U , Suntinger A , Gritsch W , Bode G , Herrmann R , Raffelsberger R , Topf H , Moser E , Föchterle J , Honsig T , Mayr K , Mayr H , Kaserbacher R , Dzien A , Galehr E , Felbermayer M , Schwarz R , Amini R , Appeltants H , Ballet A , De Niel C , Berkenboom G , Bernard X , Bouvy T , Claeys M , Dascotte Y , Davin L , De Backer T , De Meester A , De Ridder S , Dendale P , Denef K , Emonts M , Geraedts J T M , Goethals M , Grégoire J-M , Herbots T , Hoffer E , Hutse W H J , Lafontaine P , Lefebvre P , Lesseliers H , Odent G , Pasquet A , Peperstraete B , Purnode P , Rogowsky A , Rosseel M , Salembier J-P , Surmont P , Vandeplas A M F , Van de Walle S , Van den Branden F , Vandergoten P , Vanhauwaert B G , Vanneste L , Vercammen J , Verleyen D , Vermander D , Weytjens C , Rocha de Lorenzo A , Felice Castro Issa A , Mahler Mioto B , de Brito Vianna C , Okawabata C , Giusti Rossi E , Fernandes F , Pitella F , Henpin Yue Cesena F , Monteiro Ferreira J F , Junior J F , Tonet L , Machado Cesar L , Gowdak L H , Matos M A , Moretti M , Vicente Amato R , Tadeu Munhoz R , Coimbra S R , Rocha de Lorenzo A , Felice Castro Issa A , Mahler Mioto B , de Brito Vianna C , Okawabata C , Giusti Rossi E , Fernandes F , Pitella F , Henpin Yue Cesena F , Monteiro Ferreira J F , Junior J F , Tonet L , Machado Cesar L , Gowdak L H , Matos M A , Moretti M , Vicente Amato R , Tadeu Munhoz R , Coimbra S R , Luqman H N , Yakovova S , Mantcheva M , Mincheva V , Baurenski L , Karastanev K , Yordanova V , Peneva Y , Wong P , Fagan M , Sabe G , Villasenor F M , Son W K , Manyari D E , Giacomantonio N , Lubelsky B J , Ezekiel D , Leong J C S , Grover A , Vavougios J , Pesant Y , Kushner A M , Yeung M M W , Vertes G E , Nasser F J , Spensieri D , Roy A , Nguyen T T , Leclair M , Morra P , Everton Biglow C , Baril J F , Lai K , Wong D S , Martinho V , Antoniadis G A , Searles G R , Rouse D , Brisson G , King Wong S , Collette R S , Ho M S C , Constance C , Gendreau R , Kellam G W , Cieza Lara T A , Boyrazian H A , Shamsuzzaman M , Spink D R , TWong A P , Janes J , Czarnecka M , Saulnier D , Levesque G , Clavette P F , Kokis A , Orenstein T L , Shekhar Pandey A , Robb J , Verret G , Czarnecki W , Perreault F , Chouinard G , Lafrance G , Fullerton G M , LeBouthillier P , Tran Q H , Rodriguez Marrero I , Ramadan F B , Talbot P , Fazil M A , Yi-Ming Cha J , Garg S , Chehayeb R , Roy B , Chan Y K , Harlos H E , Matheson H B , Patel R , Vaz G F , Bhatt J S , Liu E , Ashton T H , Sullivan H , Quinn L P , Yared K , Gupta A K , Sullivan B , Campbell J , Pallie S , Kim H H , Savard D , Cherry J M , Gold J , Brouillette G , Belanger A , Berlingieri J , Nisker W , Boutros G , Bakbak A I , Lasalle L , Chen L L , Chen M H , Chen M Y , Chen X P , Chen Y D , Cong H L , Ding S F , Dong J T , Dong S H , Du Z M , Feng L L , Gao W , Ge H , Ge S J , Guo T , Guo Y , Huang Z , Huo Y , Jin H G , Ke Y N , Li H W , Li H M , Li Z C , Li Y J , Liu J L , Liu Q L , Liu S W , Lv S Z , Miao W , Pan G Z , Pu X D , Qian Z M , Su X , Tao J H , Wang H P , Wang J A , Wang N F , Wang T , Wang W , Wang Y , Wei M , Wu S Y , Wu Y J , Xiong L G , Xu D , Yan J , Yang K , Yang M , Yang T L , Yang X L , Yu J M , Zeng H S , Zhang H , Zhang H Q , Zhang L , Zhou S X , Zhou Y L , Bozkova J , Carda J , Dedkova S , Dufka A , Fridrich J , Hodac T , Jirmar R , Kadleckova A , Karlicek M , Krupicka J , Kuchar J , Lavicka V , Leso J , Lorenc Z , Micko M , Navratil P , Petrova I , Povolna P , Raisova L , Raska P , Ravlyk V , Schlesingerova S , Smrckova E , Sternthal P , Stursova H , Vymetal P , Wiggers P , Markenvard J , Andersen L K , Frost L , Refsgaard J , Strange S , Egstrup K , Sykulski R , Hildebrant P , Haghfelt T , Ege M , Saaby L , Cattan S , Adam M , Adda M , Aimouch N , Ardouin L , Assouline S , Aumjaud A , Barjhoux C , Baroudi R , Beaurain C , Bennouna M A , Bernard A , Bernardeau C , Blanc E , Blum I , Bodur G , Boesch C , Bonal J , Bonhomme R , Bonnet J L , Bories J , Bourachot M L , Brumelot F , Brunehaut Petaut M , Brunschwig C , Buffet P , Calmettes P , Centa I , Chartier B , Chemin P , Chometon F , Cohen J , Colin R , Cottin Y , Crespo F , Dabboura A , David F , Dehayes P , Dematteo P , Dibon O , Dodemant P , Dormagen V , Dreyfus X , Dubois J M , Duclos F , Ducoudre M , Duprez O , Durand P , Durand E , Egloff P , Escande M , Escourrou Berdou M C , Esna Ashari G , Feldmann I , Ferrieres J , Foltzer E , Fontanet B , Garandeau M , Garban T , Geffroy S , Gillet T , Godart S , Gosse P , Gratia P , Greiner O , Gueusquin A , Guiu E , Guy J M , Haddad S , Hennebelle V , Honorat S , Hourany A , Hua G , Jacquier P , Jean S , Jeremiasz R , Kohler P , Lacroix A , Leandri M , Lemiere Y , Liautard M , Loheac P , Louchart J C , Magnus P , Maheu B , Malaterre H R , Manchet G , Mantoux J , Manzi D , Marachli M , Maroun M , Meneveau N , Messas E , Mougeolle J L , Mouhat T J , Muller J , Naisseh M , Nocon P , Onger D , Ouguoujil A , Ovize M , Page E , Pareathumby K , Pleskof A , Poinson P , Pons G , Pouderou P , Poujois J N , Probst V , Prunier F , Prunier L , Puel V , Rechtman D , Rennert R , Rijavec B , Riou Y , Robert J , Roche C , Roul G , Salaun B , Saleh B , Sandalian A , Sander M , Schenowitz A , Silvestre A , Soleille H , Tabet S , Tardy M , Thomas F , Truong B , Varaldi J , Vial H , Walch J M , Wazana M , Zeitouni R , Audibert H , Alizon F , Amlaiky A , Asplanato M , Baranes C , Bariaud M , Bernasconi F , Bousquet P , Ceraulo C , De Geeter G , Donetti J , Doucet B , Doucet J , Dutoya T , Ennouchi D , Fallacher M H , Fouquet G , Fourchard V , Gdalia J , Grollier G , Guerard S , Jeannerat P A , Jobic Y , Joulie V , Jourdain P , Jouve V , Ketelers R , Khaznadar G , Kohan P , Koujan B , Lammens B , Landragin I , Moal E Le , M'Bey D , Maes F , Maheas Morlet S , Massabie R , Meddah D , Meriaux F X , Mestre C , Meyssonnier P , Migliore M , Milewski J , Millet J F , Mingam S , Nazeyrollas P , Paganelli F , Pellerin F , Petitjean F , Pinzani A , Pladys A , Primot P , Pucheu A , Rahali A , Ravoala P , Rousson D , Samama P , Sardon M , Silvestri R , Soskin P , Tabone X , Tricot C , Vaquette B , Vogel M , Weingrod M , Aboyans V , Amoretti R , Aubry J , Berthezene P , Binet D , Bonnaud X , Bonnet P , Bonny A , Bouchaya T , Boureux C , Bourgeois J M , Brottier L , Cavert B , Cleron S , Dechoux E , Delhomme C , Detienne J P , Dubs J P , Faudon B , Fellous F , Fressonnet R , Garaud Y , Garcia D , Geneves M , Gleizes J L , Guyetand C , Hermellin B , Iovescu D , Kanner J P , Khanoyan P , Leherissier A , Maximovitch A , Merian B , Messali P , Moreau Y , Moyal J , Payot L , Petoin Peuch L , Prevot J L , Raymond P , Relange D , Reymond S , Robert J F , Rosenstein H , Schneider J , Schultz R , Tanielian P , Thoin F , Thomas L , Touzet P , Steg G , Amiel Oster Sauvinet G , Baylac Domengetroy F , Chamou K , Etcheverry B , Farges J L , Fraboulet J Y , Goralski M , Janody D , Mamez B , Manlay W , Paillard F , Pelier F , Petit A , Skonieczny M , Augarde R , Fournier J B , Liandrat S , Lim P , Noury A I , Paris D , Saade M , Stordeur J M , Danchin N , Pornin M , Fauchier L , Galinier M , Balice M A , Sosner P , Yvorra S , Delcoulx E , Mouquet F , Poulard J E , Sudre A , Heno P , Biausque F , Guenoun M , Attia G , Pouwels S , Carpentier L , Verbrugge E , Ziccarelli C , Elkohen M , Tricoire J , Lang P , Huttin O , Altevogt B-M , Altmann U , Baar M , Berrisch S , Birkenhagen A , Bläse I , Blindt R , Bosch R , Brattström A , Breuer H-H , Castrucci M , Cicek S , Cierpka R , Claus M , Deissner M , Drexler M , Eggeling T , Eisele G , Enayat D , Frickel S , Gessner S , Giokoglu K , Gmehling J , Goss F , Grooterhorst P , Gysan D B , Haberl R , Haerer W , Hassler jun N , Heinemann S , Henschel F , Hinrichsen M , Hofer W , Hofmeister A , Hoh G , Horstkotte E , Jäger F , Jeserich M , Keil U , Killat H , Kimmel S , Kindel M , Kindler P , Kleta S , Könemann J , König K , Krause H , Kronberg K , Kruck I , Männl V , Meinel A , Mentz G , Meyer E , Mibach F , Möller S , Muth S , Nelböck-Huber E , Ohlmeyer D , özkan-Rashed Z , Paulus C-P , Perings S , Placke J , Raters C , Reifart N , Rink A , Rybak K , Salecker I , Schermaul K-H , Schlesinger U , Schmidt E , Schmitz K-H , Schön N , Schröder T , Sievers B , Simon M , Spengler U , Speth M , Stumpp A , Szabo S , Taggeselle J , Tamm A , Thelemann A , Thelemann C , Thümmel H , Unger G , Utech A , Volmar J , Wauer B , Wehr G , Weinrich L , Weinrich R , Windstetter U , Wirtz J H , Wittlich N , Ziehn P , Zündorf P , Avgerinos C , Gouli O , Stergiou D , Alexopoulos I , Pappas C , Petropoulos I , Chatzioakim G , Pontikakis N , Priftis C , Mpompoth P , Bourazanis I , Papathanasioy A , Avlonitis S , Zakopoulos C , Koutsimpanis G , Tsamopoulos I , Christoforidis C , Zachos V , Kalaras P , Karachaliou M , Liatas C , Pournaras G , Theodorakis G , Orestis I , Panisois K , Chalkiadakis E , Arfaras V , Kolios G , Boutsikos P , Kotsalos A , Mitropoulos D , Samothrakitis A , Svolis K , Anastasiou E , Gkinis T , Dalampyras P , Kalampalikis A , Leontaridis I , Gabriilidis S , Konstantinidis I , Plastiras V , Tarenidis P , Wahshi Y Al , Singh P P , Narayan A , Tamimi F Al , Yazeedi J Al , Ayche M , Lawati A Al , Dhanki M Al , Salustri A , Salah T , Tamimi M Y , Agrawal A , Wassef A , Baslaib F , Radaideh G Al , Yusufali A , Bazargani N , Akbar M , Abdel Wahab H , Abdel Malak S , Ghaly I , Hafez H , Kandari F Al , Haiba M , Alanbaei M , Gomaa M M , Khalifa A , Marozsén I , Édes I , Czuriga I , Cziráki A , Tóth K , Dongó Á , Túri P , Forster T , Borbola J , Bachmann B , Masszi G , Orbán M , Gerges G , Balogh G , Bajcsi É , Takács I , Nagy L , Kisjós B , Jánosi A , Nagy A , Nagy K , Büttl A , Lippai J , Sziegl Z s , Malkócs Zs , Földi A , Fikker K , Szabó E , Forrai R , Sebõk Z , Merkely B , Gupta R , Natarajan S , Dalal J , Saran R K , Mehta A , Samal M P , Khan I A , Ghose T , Sawhney J P S , Roy T , Chandra S , Modi S , Singh M M , Vijayaraghavan G , Sreenivasa Murthy L , Ramesh S S , Dayasagar Rao V , Chenniappan M S , Vadavi A , Kunhali K , Srinivasa Reddy K , Vallal Su Thillai , Khera P , Prasad B , Shukla D , Trivedi A K , Ahuja R , Rawal J , Karnik R , Hiremath M S , Kumbla D K , Shetty S R , Chonkar N S , MJuneja Late , Goyal B K , Sheahan R , Daly C , Vaughan C , Fleming S , Shiels P , Keelan P , Kiernan T , Day B , Kelly K , MacNamara F , Maguire B , Clifford A , O'Gara A , Guardigli G , Pes G , Caridi G , Frattola A , Doronzo B , Riccioni G , Lacchè A , Massari F , Orazi S , Carretta D , Provvidenza M , Pedretti R , Nicolino A , Felis S , Pernice V , Gaglione A , Gori P , Martina P , d'Alessandro V , Giacomazzi F , Terrosu P , Cernetti C , Antonicelli R , Ansalone G , Balbi M , Tamburino C , Moretti L , Tantillo S , Patriarchi F , Proietti F , Sinicropi G , Maragoni G , Mallamaci V , d'Este D , Azzolini P , Brscic E , Bongo S , Gigantino A , Perna G , Mayer M S , La Rosa C , Muscio G , Scollo V , Magliari F , Petrillo Pio C , Castellari M , Di Pasquale P , Scalzo  , Saporito F , Capuano N , Alitto F , Marchionni N , Turiel M , Bianco A , Greco C , Marullo L , Testa R , Vicentini A , Novo S , La Varra F , Tavazzi L , Conte M R , Lazerevic Z , Colivicchi F , Macchi C , Dalle Mule J , Sibilio G , Achilli A , Proto C , Kang S M , Koo B K , Hong S K , Kim W , Lee S H , Yoo B S , Seo H S , Gwon H C , Kang D H , Kwon H M , Chae I H , Oh S J , Shin J H , Goh C W , Byun Y S , Zo J H , Hong T J , Kim D S , Cha T J , Ryu J K , Kim Y J , Hwang J Y , Hur S H , Jeong M H , Oh S K , Jin D K , Jung K T , Rhew J Y , Lee S , Jeon D W , Yoon S J , Kim S H , Mintale I , Latkovskis G , Hansone S , Rozkova N , Baika A , Jasinkevica I , Abele S , Laizane I , Pontaga N , Ecina V , Mihailova I , Kondratovica A , Laucevičius A , Jurgaitienė R , Šlapikas R , Barauskienė G , Jankauskienė E , Revienė S , Zaronskienė D , Šlapikienė O B , Kupstytė N , Rinkūnienė E , Steponėnienė R , Kojelienė J , Badarienė J , Dženkevičiūtė V , Sadauskienė E , Butkuvienė I , Stankevičius R , Paliulionienė R , Snikytė R , Mažutavičius R , Jamaluddin A N , Abdul Rahim A A , Mohamed Yusof A K , Chee K H , Sadiq M A , Ramanaidu S , Sim K H , Ong T K , Fong A Y Y , Chang B C , Chua S K , Cham Y L , Mohd Amin N H , Tan S K , Khiew N Z , Said A , Abdullah C K , Cheah Y W , Sinnadurai J , Lau K K H , Choor C K , Sia K K , Ang C C , Awtar Singh J S , Abdul Wahab M Z , Wong C K , Ghapar A K , Muthu A , Mahendran K A , Jaafar A H , Ng K H , Ruhani A I , Tahir H A R , Manap H Abdul , Ch'ng B S K , Ch'ng E T , Abdullah A S , Ismail O , Sahar A S , Abdul Kareem B B , Sheikh Abdul Kader M A , Ma S K , Chan K K , Goh T H , Singh A , Liew H B , Chu C M , Bhaskaran R K M , Shah R P , Joseph K L , Hasni H Noor , Ng W K , Choo G H , Saaidin N , Yeo C K , Lai V M , Lai Y C , Tay M H , Lim B A , Luqman H N , Esperon Guillermo Llamas , de Jeús Zuñiga Sedano y America Alvarez J , Manzur F Azar , Jerjes Sánchez C , Cerda Rojas J , Carrillo Calvillo J , Petersen Aranguren F , Martínez Sánchez C , Álvarez Sangabriel A , Vieyra G , González Romero S , Puente Barragán A , Redding Escalante F , Chávez Paez J , Fernandez Valadez E , Gaxiola E , Manautou L E , Otero O Henne , Barrera Bustillos M , Leyva Pons J L , Gómez Álvarez E , Romo Santana J R , Martínez Redding J , Arias Mendoza A , Rodríguez Briones I , de Jesús Rivera Arellano J , Arenas León J L , Alcocer Gamba M , Alexanderson E , Ruíz Esparza M E , Elizondo Sifuentes L A , Briseño J L , Sandoval Rodriguez E , Fuantos Delgado M L , Sandoval Navarrete S , Casas Juarezy U , Pinales A Loera , Castro A , Carpio R Cue , Rodríguez E , Rojas G , Solache G , Díaz Juárez R , Baleón R , Ferreyra Solorio C , Ramírez Reyes H A , López Martínez M , Romero Maldonado M A , Escobedo de la Peña J , Hilario Jiménez Orozco J , Reyes Cisneros F A , Álvarez Gil J , Bautista López G , Odín de los Ríos Ibarra M , Tulevski I , Somsen G A , Miedema K , Chlewicka I , Brodzicki P , Stasiuk T , Szałkowski P , Kulig W , Maliszewski M , Królicka K , Zdrojewska J , Nikodemska I , Szpak A , Wrębiak-Trznadel M , Prokop A , Szulc M , Olszewski A , Kępa W , Banach J , Węglarz M , Gałuszka-Bilińska A , Królak A , Cisowska E , Orzechowski K , Jeżewska M , Adamaszek K , Glanowska G , Pitsch T , Matuszewska G , Nowowiejska-Wiewióra A , Dereń M , Walawski G , Sołtysiak M , Wysocki R , Jarosiński G , Drzewiecka A , Ługowski T , Jankowska A , Błaszczak P , Drozd J , Łotocka E , Duchowska R , Sobczyk D , Jarmużek P , Sidor M , Adamczyk D , Sudnik J , Cygler J , Skoczylas I , Poprawa B , Kisiel L , Kossowska U , Sikorska B , Modzelewska K , Demianiuk B , Streb W , Mularek T , Bogdański P , Kaźmierczak E , Zimoląg R , Lorenc J , Furtak R , Regulska A , Winter M , Fic M , Turek P , Nowicka E , Bryl W , Lenartowska L , Jerzykowska O , Maćków M , Gadziński W , Kacorzyk R , Zalewska D , Sadłowski R , Słaboszewska J , Gruchała M , Frankiewicz A , Walczewska J , Adamkiewicz A , Chyrek R , Jankowska L , Correia A , Girńo A , Herdade Á , Sequeira A , Tavares E Taveira A , Gonzaga A , Ribeiro A , Albuquerque A , Fernandes A , Estriga A , Rocha De Almeida A , Lourenço A , Pereira A , Faria A , Carvalho De Moura B , Camossa C , Alves C , Aguiar C , Rodrigues C , Wellenkamp E , Fernandes De Sousa F , Moreira Pinto F , Matias F , Silva Alves G , Bragança G , Proença G , Mariano Pêgo G , Vinhas H , Arroja I , Morais J , Silva E Sá J , Vasconcelos J , Matos J , Freitas J , Ferreira J , Costa J , Alcaravela J , Mimoso J , Antunes J , Ferreira Dos Santos J , Nobre Dos santos J , Fernandes J , Chambel De Aguiar J , Moreira J , Carvalho J , Forte De Carvalho J , Calaça J , Simões L , Lopes Antunes L , Soares L , Semedo L , Macedo L , Sargento L , Basto L , Rebelo L , Oliveira L , Catarino Carvalho M , Alves Costa M , Gamboa M C , Ferrńo E Vasconcelos M F , Custódio M H , Mendonça M I , Pinto Vaz M J , Espiga De Macedo M , Lazaro M , Martins Oliveira M , Pelicano N , Lousada N , Rodrigues O , Matos Dias P , Fonseca P F , Ferreira P , Farto E Abreu P , Monteiro P , Seabra Gomes R , Carvalho R , Santos R , Rosado Soares R , Baptista S , Reis Monteiro S , Gil V , Sanfins V , Martins V , Anghel M , Arsenescu Georgescu C , Babes K , Banu M , Beyer R , Bratu I , Bumbu A , Capalneanu R , Chioncel O D , Chiscaneanu T , Christodorescu R , Cindea Nica N , Cinteza M , Coman S , Constantinescu M , Craiu E , Dan G A , Dan D C , Dan A , David C M , Dorobantu M , Farcas D , Firastrau V , Florescu C , Ghicu A , Giuca A , Grigoriu R , Ionescu D D , Iosipescu L C , Ivan M V , Lighezan D , Magheru S , Magherusan M , Marinescu S M , Motoc A C , Musetescu R , Rau M , Rotaru H Rus L , Sirbu O , Sorodoc L , Spinu C M , Stanciulescu G , Statescu C , Toringhibel M , Trambitas R , Trocan N , Tudose A , Vinereanu D , Zagreanu M , Motomancea R , Militaru C , Dymova D , Semenova N , Zherebtsova A , Fedoskin V , Gurianova N , Bolotova N , Knyazeva V , Spitsina T , Sytilina N , Atamanchuk N , Giorgadze M , Zarechnova S , Kutuzova S , Sharapova Y , Stelmakh I , Sinyukova O , Rostik S , Evtukhova L , Sukhanova L , Makhieva T , Tereshko S , Kolesnikov V , Kochurov E , Marchenko B , Nurgalieva S , Galeeva Z , Andreicheva E , Zakirova V , Baleeva L , Minsafina A , Borodina N , Arkhipova Y , Krechunova T , Scherbak M , Merkhi A , Aksyutina N , Ratovskaya O , Suglobova E , Kozhelenko Y , Potapova E , Poluyanova G , Naberezhnova N , Daniels E , Atueva K , Tsaryabina L , Kurekhyan A , Khishova N , Dubinina E , Demina O , Mochkina P , Bukanina E , Tolpygina S , Polyanskaya Y , Malysheva A , Kheliya T , Serazhim A , Voronina V , Lukina Y , Dubinskaya R , Dmitrieva N , Kuzyakina M , Khartova N , Bokuchava N , Smirnova E , Esenokova A , Pavlova Y , Smirnova O , Astrakhantseva P , Bykovskaya S , Charikova O , Berdnik K , Karaseva T , Zhabina L , Oleinikova N , Dzhkha O , Grigoryan S , Yakovenko E , Ivaschenko T , Kiseleva I , Shokina T , Novikova M , Khodanov A , Popova L , Latyntseva L , Kilaberiya O , Makarenkova K , Nosova N , Gerasimova T , Boikova L , Sharapova N , Kulikova Y , Pasechnaya N , Bulakhova E , Kurochkina S , Bratishko I , Likhobabina O , Panova E , Voronina N , Bizyaeva N , Gusev O , Nevolina N , Arsentieva T , Budanova I , London E , Melnikova A , Khripun A , Polyaeva L , Osadchuk E , Krasnoslobodskaya O , Yakimova N , Lugin A , Sosnova Y , Il'ina E , Kositsina G , Shanina I , Kostomarova S , Malgina M , Omelchenko M , Gorlova I , Eidelman S , Salakhova A , Bondarenko B , Sopia R , Baboshina N , Eliseeva N , Tumarov F , Petrochenko N , Khudina I , Arabadzhi N , Samakhovets V , Tkhorzhevskaya L , Sinotova T , Zherlitsyna E , Minkin S , Petrova N , Tikhonov Y , Shmakova N , Abduvalieva V , Kuzmicheva M , Nikolaeva L , Varezhnikova O , Dmitrieva T , Mikhailova E , Yanina Y , Kapustina L , Vazhdaeva Z , Golovina G , Fedorova N , Nikolaeva I , Fillipova O , Gareeva L , Tuktarova F , Khmelevskikh N , Karnot V , Golub M , Surovtseva I , Kulygina V , Shelomova N , Kruglova I , Pokrovskaya I , Rodina O , Polkina L , Biryukova N , Filippova E , Kotova E , Ignatieva T , Alekseeva T , Gruznykh L , Mozerova E , Moksyuta E , Kosachek E , Srtumilenko N , Baranova O , Voronova T , Bayakhchan L , Grudtsina I , Gorshkova L , Shamsutdinova O , Getman M , Gorodilova I , Karnaukhova N , Rotenberger V , Isaeva L , Lebischak G , Ryzhkova V , Usoltseva E , Mescharekova D , Tavlueva E , Mineeva E , Stikhurova M , Kosareva L , Grechishkina O , Nikishina S , Ilyukhina A , Gureeva O , Soin I , Erofeev S , Lebedev S , Kudryavtsev l , Gamzatov E , Maximchuk N , Grekhova L , Kolevatova L , Kazakovtseva M , Kolesova O , Zharikova L , Kukaleva V , Starostina N , Grushetskaya I , Kazachkova V , Pashentseva I , Shimonenko S , Sirazov I , Chernozemova A , Golubeva O , Mingalaeva S , Zatsarina E , Kozlov D , Davydova N , Larina O , Alhabib K F , Hersi A , Al-Becker H , AlFaleh H , Mobeirek A , Arafah M , Al M , El F , Zaibag M Al , Bdeir M , Suliman I , Mukhtar A , Omar H , Jamiel A , Elkrail A , Alanazy M , Habab M , Ashmak K , Nourallah R , Mak K H , Singh B , Chee T S , Koo C C , Low L P , Nair V P , Ng K S , Quek S S S , Tan E H M , Ng A L R , Chuang H H , Kamensky G , Kaliska G , Murin J , Hatalova K , Gaspar L , Simkova I , Dubrava J , Pjontek J , Pella D , Banikova A , Szentivanyi M , Kovar F , Benacka J , Gonos I , Fazekas F , Kycina P , Poles J , Fras Z , Pernat A , Veternik A , černič-Šuligoj N , Kerbev M , Krajnc I , Zagožen P , Alam A , Brown B , Luke B , Variava E , Nethononda R , Joubert S , Matthews P , Nkombua L , Antia V , Naidoo D P , Bhayat J , George S K , Ranjith N , Vawda G H M , Govender S , Soosiwala I , Shein K , Panajatovic M , Flores J , Khan M S H , Blignaut S , Coetzee K , Burgess L , Freeman V , Theron H D , Arnau M A , Vives  , Abardía Oliva F J , Aguar Carrascosa P , Albero Martínez V , Alegret Colomer J M , Alegría Ezquerra E , Almeida Fernández C A , Alvarenga Recalde N , Alvarez Auñon A , Alvarez García P , Amo Fernández C , Amoros Galito C , Ancín Viguiristi R , Aparici Feal M , Ardiaca Capell A , Arnedillo Pardo J , Arquero García G , Arrarte Esteban V , Baquero Alonso M , Barahona Pérez P , BardajíMayor J L , Barriales Alvarez V , Batalla Celorio A , Berzal Martín B , Bierge Valero D , Blanco Castiñeiras J , Bosa Ojeda F , Botana Penas C , Brufau Redondo H , Bruguera Cortada J , Cabrera Solé R , Calvo Iglesias F , Cantabrana Miguel S , Carrillo Cardoso R , Casanovas Pié M , Casas Giménez P , Castillo Lueña E , Castillo Moreno J A , Castillo Orive M , Chirivella González A , Chopo Alcubilla J M , Climent Payá V , Cobos Gil M A , Colomer Martín J L , Concepción Clemente A , Cortés Sánchez R , Cremer Luengo D , Darnes Soler S , de Andrés Novales J , De Castro Aritmendiz R , de Juan Baguda J , de los Reyes López M , Delgado Prieto J L , Díaz Díaz J L , Escobar Cervantes C , Ezcurdia Sasieta J , Facila Rubio L , Falces Salvador C , Federico Zaragoza P , Fernández Alvarez R , Fernández de la Cigoña F , Fernández Lázaro L A , Fernández Léoz L C , Fernández Mouzo R , Fernández-Valls Gómez M , Ferreiro Rodríguez B , Franco Aranda C , Freire Corzo J , Fuertes Alonso J , Fuertes Beneitez J , Galve Basilio E , García García C , García Martínez M J , García González M J , García Ortego S , García Pindado C , García Saavedra V , García-Moll Marimón J , Gascueña Rubia R , Gentille Lorente D , Gervas Pavón H , Gilabert Gómez R , Gómez Barrado J J , Gómez Doblas J J , Gómez Martinez M J , González Juanatey C , González Toda V , Gonzalvez Ortega M , Gordillo Higuero E , Hernández Afonso J , Herrera Fernández D , Homs Espinach E , Idoate Gastearena A , Irurita Latasa M , Izquierdo González R , Jaquet Herter M , Lagares Carballo M , Lastra Galán J A , Limeres González B , López Aranda M A , López Barreiro L , López Gómez D , López Granados A , López Mouriño V , López-Sendón J L , Luaces Méndez M , Mainar Latorre L , Marín Araez E , Marín Ortuño F , Martín Santana A , Martínez Florez J , Martínez González J , Martínez Rivero J F , Marzal Martín D , Mazzanti Mignaqui G F , Melero Pita A , Molina Laborda E , Miñana Escrivá G , Montagud Saavedra V , Montero Gaspar M A , Mora Robles J , Morales González J , Moreno Arribas J , Moreno Casquete M T , Moya López C , Murga Eizagaechevarría N , Narro García F , Navarro Manchón J , Navas Navas C , Novo García E , Núñez Gamero J A , Ordóñez España A , Ortiz de Murua López J A , Orts Soler E , Otero Chulian E , Pastor Torres L , Paule Sánchez A J , Paz Bermejo M A , Pedrosa del Moral V , Peña Pérez G , Perea Egido J Á , Pérez de Isla L , Pérez Ibiricu S , Pérez Martínez M A , Pérez Paredes M , Peris Domingo E , Peset Cubero A M , Pinar Sopena J , Pindado Rodríguez C , Pinilla Lozano M J , Piñero Ramírez C , Porras Ramos Y , Prieto Moriche E , Ramos Ariznabarreta F , Rayo Gutiérrez M , Roca Catalán J M , Rodríguez Almodóvar A , Rodríguez Collado J , Rodríguez Fernández A , Rodríguez Fernández J A , Rodríguez Hernández J A , Rodríguez Tejero I , Romeo Castillejo I , Romero Alvira D , Romero Hinojosa J A , Romero Menor C , Rossi Sevillano P , Rueda Calle E C , Rueda Soriano J , Ruiz Pérez P , Sagastagoitia Gorostiza T , Sainz Hidalgo I , Sandin Rollán M , Santaolalla Rodríguez S , Santas Olmeda E , Santos Iglesias J L , Sanz Rodríguez M L , Segura Laborda I , Serrano García S , Sevilla Toral B , Silva Melchor L , Simarro Martín-Ambrioso E , Sola Casado R , Soriano Navarro C , Soto Ruiz M I , Talavera Calle P , Teijeira Fernández E , Torres Díaz P L , Troncoso Gil A , Trujillo Berraquero F , Ulecia Martínez M A , Umaran Sánchez J , Vaticón Herreros C , Vázquez García A , Vega Barbado J L , Velasco Espejo-Saavedra E , Vicente Vera T , Vida Gutiérrez M , Villar Mariscal C , Vives Boniato G , Wu Amen L , Yanes Bowden G , Yañez Wonenburger J C , Zamorano Gómez J L , Zarauza Navarro J , Monnier P , Jaussi A , Forclaz A , Grobéty M , Schlueter L , Vuille C , Nacht C A , Evéquoz D , Ciaroni S , Dominé F , Bérubé J , Rickli H , Hellermann J , Koller R , Bourgeois G , Engel R , Niederberger C , Stadler P , Gnädinger M , Schmied C , Wettstein T , Hilti P , Chételat C A , Sepulcri F , Brunner H , Schindler J , Kraus M , Vivekaphirat V , Panpunnung S , Kuanprasert S , Wongcharoen W , Phrommintikul A , Harinasuta J , Si O , Chaithiraphan V , Boonyasirinant T , Boonyapisit W , Kittipovanonth M , Buakhamsri A , Piyayotai D , Hutayanon P , Junejo S , Aiyegbayo O , Ancliff H , Bradshaw C , Cervenak R , Choi H , George E , Gilmour I , Gough D , Idrissi A , Ingham J , Al B , Liston A , Mackrell J , Pattison I , Ramachandran R , Ray N , Reddy G , Sen I , Shetty K , Singh L , Stanley M , Wallace A , Weatherhead M , Gilbert T , McCansh G , Higgins S , Killeen C , Cromarty I , Franklin P , Pinch E , Dhesi A , Dernedde C , Lawrence M , Simper H , Noble M , Dalton G , Stevens L , Berry P , Hand C , Oliver R , Jones H , Sampson P , Taylor N , Grogono R , Dalrymple J , Martin A , Thurston S , Elsby K , Vallis M , Morrison G , Lang C , Watson A , Thomson A , Dougall H , Hay B La , Compson L , McCracken A , Calder J , Weber F , Richmond D , Brownlie R , Brown G , MacCowan H , Heap A , Perry M , Holden L A , Scott G , Haldane N , Hood S , Cullen I , Bell J , McNaught P , Sharif M , Dunn J , Hay D , Ross S , Shaw R , Hay L , Langridge S , Burns R , Crawford L , Kennedy A , Logan D , McAlavey P , Brown M , Costello P , McLaren G , Potter A , McPherson J , Drijfhout M , Finlayson J , Troup D , Woodall A , Pearce J , Williams S , Parkar W , Yusuf A , Benett I , Bishop P , Thomas H , Caldwell I , Ormiston P , Kwok S , Wright S , Kanumilli N , Saul P , Milligan H , Wilkinson I , Vance A , Paul N , Paul C , Shaikh I , Ellis R , Vites N , Steeds R , Goodwin D , Aftab A , Banham S , Chauhan N , Grocutt M S , Gupte A , Jordan R , Jheeta B S , Ladha K , Nazir M , Pal R , Patel R P , McManus R , Singal A , Saunders P , Syed A B , Bahal A , Dau H , Walker D M , McNeilly R , Bolidai A , MacCarthy N , Lawton D , Vardhani M , Sengupta G , Kinloch D , Howie F , Serrano A , Paget S E , Till R , Seal P , Morrell J , Maxwell T , Singh G , Warden D , Elias R , Dixon C , Pandey R K , Challenor V , Davies S , Gibbs M , Gillet A , Goldie C , Jarvis I , Johnson P , Malden M , Moore J , Morton C , Nehrig K , Sheringham P , Wilson G , Halcox J , O'Connor I , Ling K , Edwards D , Charles H , Weatherup A , Davies E , Watkins N , Morgan D , Davies R , Lindsay A , Beacock D , Balai R , Kirmond P , Brindle P , Bundy C , Cahill T , Dayani A , Eavis P , Mohr S , Hayne S , Krasucki C , Micheals M , Orpen I , Parker I , Sewell R , Sharp D , Smith A , Stevens A , Upton J , Victory J , Wernham C , Davis R , Mays C , Andrews M , Takhar J , Travill C , Choudhury P , Matta W , Ihonor A , O'Dong C , Rahman S , Singer P , Gillam S , Bath P S , Razzaq N , O'Toole O , Rowe P , Williams H , Kalra P , Allcock A , Tucker A , Sprott V , Kyd K , Cunliffe G , Arden C , Bateman A , Kassianos G , Sinclair D , Turner C , Jagathesan R , Sattar F , Ashford A , Chukwu A , Taylor H , Pradhan R , Rundell T , Howlett R , Bietzk R , Patel R , Myint M , Partington M , O'Reilly F , Baverstock M , Dixon S , Tennekoon M , Brand N , Haimes P , Keller P , Whetstone S , Davis R , Mays C , Andrews M , Takhar J , Parker L , Anscombe M , Beale G , Murphy L , Smith A , Brown S , Lindford J , Serrano A , Preston S , Sethi R , Hutchinson S , Kovyrshyna O , Rogozhyna V , Kiver T , Vasylenko V , Kucheryava L , Salimova S , Alekseenko V , Gukov O , Myhailiv I , Kardashevskaya L , Prikolota O , Bashkirtcev O , Andreev E , Tkachenko L , Mospan M , Batushkin V , Reshotko D , Safonova L , Ogorodnichuk A , Pustovit S , Romanov S , Burlakova L , Voloshko Y , Lafarenko V , Vlasuk Z , Leshchuk O , Chushak S , Koval V , Stasuk O , Pogrebna O , Kornienko S , Tikhonova S , Fesenko T , Kuzmina T , Ushakov O , Vechtomova N , Potapska L , Illushechkin I , Kryvenkova E , Lysunets O , Tsygankov O , Bardachenko L , Voloshyna L , Ginzburg V , Franskyavichene L , Korotich T , Vyshnevaya N , Bilous N , Kulinich S , Kulik V , Sadykova I , Zalyzniak O , Berezhna T , Molotyagina S , Nguyen L V , Pham M H , Pham H T , Khong N H , Do K B , LE T B , Do P A , Do T C , Nguyen N Q , Do Q H , Vu K C , Pham N H , Pham T H T , Ta M C , Phan D P , Nguyen T T H , Pham T T N , To T L , Le V T , Dang L , Bui L , Pham T T H , Phan H H , Bui T T H , Tuong T V A , Nguyen T P , Nguyen T H , Nguyen B K , Vu D B , Pham N S , Do T Q , Pham T S , Dang V D , Le D T , Do V C , Nguyen T K L , Luong H D , Luu T Q , Pham N V , Huynh T K , Tu N T H , Ngo K A , Nguyen T T C , ONG T T L , Doan V B , Kim T B , Vo T N , Tran T T T , Nguyen T A , Tran V D , Nguyen A K , Tran A C , Ngo M H , Vu N H , Ly I T , Tran N P H , Tran L U P , Nguyen T N , Tran T H , Truong P H , Mai T L , Hoang V S , Bui C M A , Dang V P , Truong Q B , Vo M P , Nguyen V T , Chau N H , Ta T T H , Dinh H N , Tran H , Nguyen H K N , Chung A , Chung E , Martina B , Angela R , Ramoutar P , Fillet R , Tilluckdharry R , Dookie T , Foster E , Hart C , Omardeen F , Ramphall S , Lalla C , Henry R , Cheng J , Elliott V , Falconer H , Hurlock L , Ishmael R , Lalljie G , Lee K , Liqui A , Massay R , Mohammed H , Brown C , Daniel R , Didier M 
Published: May 2024

Background and Aims

It has been reported that patients without standard modifiable cardiovascular (CV) risk factors (SMuRFs—diabetes, dyslipidaemia, hypertension, and smoking) presenting with first myocardial infarction (MI), especially women, have a higher in-hospital mortality than patients with risk factors, and possibly a lower long-term risk provided they survive the post-infarct period. This study aims to explore the long-term outcomes of SMuRF-less patients with stable coronary artery disease (CAD).

Methods

CLARIFY is an observational cohort of 32 703 outpatients with stable CAD enrolled between 2009 and 2010 in 45 countries. The baseline characteristics and clinical outcomes of patients with and without SMuRFs were compared. The primary outcome was a composite of 5-year CV death or non-fatal MI. Secondary outcomes were 5-year all-cause mortality and major adverse cardiovascular events (MACE—CV death, non-fatal MI, or non-fatal stroke).

Results

Among 22 132 patients with complete risk factor and outcome information, 977 (4.4%) were SMuRF-less. Age, sex, and time since CAD diagnosis were similar across groups. SMuRF-less patients had a lower 5-year rate of CV death or non-fatal MI (5.43% [95% CI 4.08–7.19] vs. 7.68% [95% CI 7.30–8.08], P = 0.012), all-cause mortality, and MACE. Similar results were found after adjustments. Clinical event rates increased steadily with the number of SMuRFs. The benefit of SMuRF-less status was particularly pronounced in women.

Conclusions

SMuRF-less patients with stable CAD have a substantial but significantly lower 5-year rate of CV death or non-fatal MI than patients with risk factors. The risk of CV outcomes increases steadily with the number of risk factors.