bluuebunny/crossref_metadata_2025 huggingface dataset:
UNSUR KEBARUAN DALAM DESAIN INDUSTRI KEMASAN MINUMAN JAHE
Authors: Nadhira Putri Allya , Bustani Simona
Published: June 2022

Sengketa desain industri yang terjadi antara PT. Total Asri Sumber Alam dengan PT. Aneka Boga Citra terkait dugaan tidak adanya unsur kebaruan pada desain industri kemasan minuman jahe milik PT. Aneka Boga Citra sejalan dengan Pasal 2 Undang-Undang Desain Industri. Pokok permasalahannya yaitu bagaimana menentukan nilai kebaruan desain industri kemasan minuman jahe dalam memperoleh hak desain industri berlandaskan Undang-Undang Desain Industri dan bagaimana akibat hukum setelah adanya putusan kasasi oleh Mahkamah Agung terhadap sengketa unsur kebaruan desain industri kemasan minuman jahe milik PT. Total Asri Sumber Alam dengan desain industri kemasan minuman jahe milik PT. Aneka Boga Citra. Adapun cara penelitian yang diaplikasikan yakni penelitian hukum normatif yang bersifat deskriptif diikuti memakai data sekunder berbahan hukum primer dan sekunder serta diuraikan secara kualitatif juga diambil kesimpulan dengan cara deduktif. Penelitian hukum ini menghasilkan oleh karena desain industri PT. Aneka Boga Citra memiliki konfigurasi bentuk, gambar dan komposisi warna yang serupa dengan desain industri yang telah dipublikasi sebelumnya oleh PT. Total Asri Sumber Alam, maka desain industri PT. Aneka Boga Citra bukan desain industri yang baru sejalan dengan Pasal 2 Undang-Undang Desain Industri. Hakim Mahkamah Agung juga menyatakan desain industri PT. Aneka Boga Citra batal pendaftaran dengan segala akibat hukumnya sesuai Pasal 43 Undang-Undang Desain Industri.
ANALISIS PEMBAGIAN WARIS DARI HARTA BAWAAN MENURUT KUHPER & UUP 1974
Authors: Valencia Mellisa , Bakri Khairani
Published: June 2022

Salah satu akibat perkawinan adanya harta perkawinan. Harta perkawinan terdiri dari harta bawaan, harta bersama, dan harta dari masing-masing pihak yang diperoleh sepanjang perkawinan. Dengan terjadinya kematian, harta perkawinan menjadi harta waris yang diberikan kepada ahli waris. Pokok permasalahannya adalah : 1) Bagaimana pembagian harta bawaan dalam pembagian waris menurut Kitab Undang-Undang Hukum Perdata dan Undang-Undang Nomor 1 Tahun 1974 tentang Perkawinan? 2) Apakah Putusan Nomor 79/Pdt.G/2020/PN.Rap sudah sesuai menurut Kitab Undang-Undang Hukum Perdata dan Undang-Undang Nomor 1 Tahun 1974 tentang Perkawinan? Penelitian ini adalah penelitian hukum normatif, dengan sifat deskriptif analitis. Penelitian ini menggunakan data sekunder dan bahan hukum primer dan sekunder. Data dianalisis secara kualitatif dengan penarikan kesimpulan secara deduktif. Kesimpulannya adalah: 1) Dengan terjadinya kematian maka harta bawaan menjadi harta waris. Sehingga menurut Kitab Undang-Undang Hukum Perdata dan Undang-Undang Perkawinan, dikaitkan dengan kasus, maka harta bawaan sebagai harta waris Hua Sin diberikan kepada istrinya sebagai ahli waris golongan pertama. 2) Putusan Nomor 79/Pdt.G/2020/PN Rap belum sesuai dengan Pasal 852 Kitab Undang-Undang Hukum Perdata jo. Pasal 35 hingga Pasal 37 Undang-undang Perkawinan.
Beneficios de la integración de inmigrantes en el desarrollo de las economías locales: un análisis de gobernanza multinivel en Gdansk y Barcelona
Authors: Carmona Fernández María , Sianes Antonio
Published: June 2022

Debido a la ubicuidad de los movimientos migratorios, las sociedades en las que vivimos son cada día más multiculturales, fenómeno que afecta también a la zona europea. En esta región, el reparto competencial en materia migratoria ha llevado a una pugna entre gobiernos nacionales y Unión Europea, especialmente visible en la discrecionalidad con que los Estados interpretan las directivas europeas en materia de integración. La reciente aprobación de la Agenda 2030 y su propuesta de dar respuesta localizada a los desafíos de la sociedad actual ha favorecido la entrada en liza de un nuevo actor: los gobiernos locales. Estos, especialmente en las grandes ciudades europeas, están emergiendo como un actor innovador en el desarrollo de políticas propias de integración.
Los beneficios que supone la integración para las personas migrantes han sido ampliamente identificados por la literatura. A pesar de que por un tiempo se requiere una inversión inicial cuando se permite la entrada de refugiados a un país, los beneficios que estos aportan comienzan a aparecer en el medio y largo plazo, una vez se les otorga la autorización legal para trabajar. Sin embargo, aún persiste un mayor debate acerca de los efectos que los diferentes modelos de integración tienen sobre el desarrollo de las economías locales en materias como el rejuvenecimiento poblacional, el trabajo decente o el fortalecimiento de las instituciones, así como la extensión de la protección social. Para arrojar luz sobre este tema, en este estudio se analizan los casos de Barcelona y Gdansk, mostrando cómo los gobiernos locales están adoptando políticas de integración no siempre convergentes con las de sus gobiernos nacionales. El estudio comparado de estas experiencias con un enfoque de gobernanza multinivel permitirá comprender qué factores impulsan estas políticas y su impacto en el desarrollo de las economías locales.
Evidence of external contact between the Pacific Basin and the east coast of Australia during the Holocene: A review
Authors: Rowland Michael J. , Kerkhove Raymond C.
Published: June 2022

The prospect that First Nations Australians were in contact with cultures beyond Australia prior to European arrival has fascinated theorists for over a century. Early views tended to see Aboriginal culture as too primitive to have independently developed ‘higher level’ cultural traits. Once this view was abandoned, further enquiry into external contact largely ceased. However, it has been gradually recognised that transformations occurred within Australia not only independently but also through external elements arriving from the north (Macassans and Papuans). This paper offers perhaps the first comprehensive overview of a less studied potential conduit: the eastern seaboard of Australia. Given the vast scale of the eastern seaboard (and its geographic position directly opposite the seafaring cultures of the Pacific Basin it is surprising that the notion of contact between these two realms has received such limited attention. The east coast is a potentially very large target for contact. Queensland and New South Wales mainland and island coastlines comprise in excess of 15,000 km. The Pacific Basin is similarly a huge potential source for contact, covering over one-third of the world’s surface, and containing over 20,000 islands. Our paper first considers the contrast between studies of the eastern and western edges of the Pacific Basin, and then the means (and evidence) by which ‘contact’ is normally discerned. We next consider the potential for contact based on ocean currents and similar factors. The bulk of the paper assesses specific source regions and purported evidence of contact from these regions: Papua New Guinea, Island Melanesia, Polynesia and two islands between these areas (Norfolk and Lord Howe). Our study concludes that evidence for Pacific-Australian contact ought to be relatively abundant, given the size of the source area (the Pacific Basin) and the target area (the eastern seaboard). Instead, contact must have been very limited and sporadic, as most evidence has been either inconclusive or requires further substantiation. Equally, the impact of these cultures on the development of Australian First Nations seems to have been negligible. On the other hand, this review accumulated enough evidence to suggest there was considerable potential for such contacts. We conclude that archaeological frameworks should be developed to investigate purported and possible Pacific-Eastern seaboard contacts.
STRATEGIC DIRECTIONS OF COMPETITIVE DEVELOPMENT OF AGRICULTURAL SECTOR AND FOOD INDUSTRY IN THE CONTEXT OF SUSTAINABLE DEVELOPMEN IN THE CONDITIONS OF GLOBALIZATION
Authors:   Chernihiv Polytechnic National University, Povna Svitlana , Shabardina Yuliia ,   Chernihiv Polytechnic National University
Published: June 2022

The article analyzes the level of food security in Ukraine, as well as the level of development of enterprises in the agricultural sector and food industry through the dynamics of their exports and imports. It is determined that the food industry of Ukraine is not developing at the pace appropriate to the agricultural sector and is losing its position even in the domestic market. Sale of agricultural raw materials from Ukraine in large volumes is actively developing the crop sector, but leads to the manifestation of the phenomenon of the "resource curse". Additional processing of agricultural products within the country could increase added value and the level of prosperity in the country. Factors influencing the level of competitiveness of food industry enterprises are analyzed. Strategic directions of competitive development of the agricultural sector and food industry are singled out. Today the agricultural sector and the food industry are able to achieve the first three goals of sustainable development with a sufficient level of mutually beneficial cooperation at least nationally. The food industry companies are facing the biggest challenge, they are required to show initiative and ability to develop in line with global trends. The industry does not take full advantage of the existing competitive advantages provided by the highly developed agricultural sector as its raw material base. By selling not raw materials (grain) on the world market, but products of its processing, enterprises have the opportunity to significantly increase value added and increase the level of welfare in Ukraine. However, the strategic guidelines for the development of the food industry should be to focused on improving product quality and ensuring long-term mutually beneficial cooperation with the agricultural sector
FEATURES OF THE EXPORT MARKETING COMPLEX AGRICULTURAL ENTERPRISES
Authors:   West Ukrainian National University, Turchyn Liuba
Published: June 2022

The article identifies the basic elements for taking into account the current trends in the development of commercial enterprises, which ensure the existence and development of the brand in today's digitalization. The mechanism of formation of brand-strategy of the trade enterprise is offered and substantiated. Within the framework of the proposed mechanism, a functional is combined that combines functions, approaches, models, principles, methods and tools, support. In particular, such an element of the mechanism as collateral covers regulatory support, economic resources, organizational structure, intangible assets and financial resources, as well as the process component. In turn, the process component consists of the following stages: substantiation of the strategy, definition of the strategy, implementation of the strategy and monitoring of the effectiveness of the strategy. The first stage - substantiation of the strategy - includes the following processes: diagnosis: analysis of the internal environment of the enterprise (audit of intellectual capital and brand analysis); large-scale research; market analysis (segmentation, assessment of market capacity and its segments, market dynamics, competition analysis, etc.); risk analysis. At the second stage - definition of strategy - there is: definition of the purpose of development and advancement of a brand (creation of strategy of positioning, development of communication strategy; development of strategy of advancement; creation of unique attributes of a brand); formation of alternative strategies for brand development (brands) of the enterprise and selection of the most acceptable alternative; brand architecture development. The third stage - the implementation of the strategy - includes the following processes: selection and implementation of a set of brand management measures; development and implementation of appropriate marketing communications; risk management. At the fourth stage - monitoring the effectiveness of the brand strategy - are carried out: constant audit of the brand (brands) of the enterprise at all stages of the life cycle; evaluating the effectiveness of the selected brand strategy; brand valuation. It is established that the effectiveness of choosing the appropriate brand strategy is possible only if the appropriate sequence, which is reflected within the stages of the process component of the developed mechanism for forming a brand strategy of a commercial enterprise.
ENSURING ECONOMIC SECURITY OF THE COUNTRY ON THE BASIS OF IMPLEMENTATION OF WORLD ANTI-CORRUPTION MODELS AND DETERMINANTS OF THEIR FUNCTIONING
Authors:   Chernihiv National University of Technology, Samiilenko Halyna
Published: June 2022

The article considers the concept of "corruption", the essence of which depends on the scope of its application. There is no single definition of this definition. The sources of corruption, the origins of domestic corruption actions have been studied and indicated, as well as such groups of causes of corruption as: political, economic, social, legal and organizational. It is established that corruption has a negative impact on the economic development of the country and contributes to the eco-nomic danger of the state. Two leading models of anti-corruption activities have been identified: Singaporean or Asian and Swedish or Scandinavian. The essence of the first is to implement a vertical strategy aimed at obtaining quick results, the result of which is not the complete elimination of corruption, but finding a level that is acceptable for both government and society. The second model is the application of a horizontal strategy aimed at the consistent implementation of anti-corruption activities based on anti-corruption incentives. The countries that use the first model primarily include: Singapore, Japan, South Korea, North Korea, the second is used by countries such as Sweden, Finland, Denmark, the Netherlands and others. The article examines the experience of these countries in implementing anti-corruption models, through which they managed to develop effective mechanisms to combat corruption, reduce its volume and establish control over the activities of officials, based on which they identified and studied the determinants used to prevent and overcoming corruption. The analysis of foreign experience in combating, preventing and combating corruption has made it possible to identify leading trends, mechanisms and tools, the adaptation of which can be useful for our country. These are, first of all, such as: formation of a conscious civil society on intolerance of corruption through constant informational explanations about the negativity of this phenomenon, implementation of various anti-corruption programs and projects; intensifying the activities of public organizations and expanding their influence on anti-corruption processes by effectively introducing their represent-atives to the supervisory and advisory boards of public administration bodies; application of anti-corruption measures, mainly of preventive and encouraging nature; expanding the involvement of e-government, Internet platforms, interactive websites in order to quickly respond to citizens' reports of facts that contain corruption components.
THE GENESIS OF SCIENTIFIC THOUGHT ABOUT THE ESSENCE OF THE LABOR MARKET
Authors:   Chernihiv Polytechnic National University, Minina Oksana , Shadura-Nykyporets Nataliia ,   Chernihiv Polytechnic National University
Published: June 2022

n modern transitional conditions, the labor market is one of the most important, complex and changing elements of the economy at the micro, meso and macro levels. Its specificity is explained not only by the fact that the interests of employer and employee are intertwined, working conditions, employment and wages are formed, but also by the fact that the labor market is a generalized indicator of a wide range of socio-economic phenomena and social development processes. The purpose of this article is to study the genesis of the essence of the labor market. Since economic categories are historical in nature, their essence and interpretation is determined by the socio-historical conditions of a certain stage of human development, it is important to understand what meaning representatives of leading economic schools saw in the labor market. It is important to reveal this content through the prism of the dominant socio-economic ideas of the period and in the context of the basic concepts of the relevant economic schools and areas. Studing the genesis of scientific thought about the essence of the labor market allows to form a comprehensive multidimensional understanding of this concept and its features in today's changing world. The essence, functions, conditions of the labor market formation and functionation are marked by significant controversy, es-pecially in historical retrospect. Therefore, the development of theoretical and methodological foundations for the functioning of the modern labor market requires studying the genesis of formation of scientific thought about its content. V.N. Tarasevich says: “To show the genesis of category means, firstly, to determine its genetic basis, origin, sources; secondly, to highlight the stages of its movement, the levels that characterize the process of its deployment from the essence to increasingly specific forms”. A review of the genesis of the essence of the category "labor market" in the main economic schools found that it is a dynamic socioeconomic system, which in historical development undergoes significant changes, evolves, and therefore its development is reflected in changing approaches to definition.
Philosophy of the Digital Version of the World: From the Foundation to the Practices Book Review: Alekseev А. Р., Alekseeva 1. Yu. The Fate of Intelligence and the Mission of Reason: Philosophy before the Challenges of the Era of Digitalization. Monograph. Moscow, Prospect, 2021
Authors: Bryzgalina E. V.
Published: June 2022

The publication presents a review of the monograph by Alekseyev Alexander Petrovich and Alekseeva Irina Yurievna “The Fate of intelligence and the mission of reason: philosophy facing the challenges of the era of digitalization”. The authors systematically and deeply analyze the theoretical and cognitive, socio-philosophical, philosophical and anthropological problems that arise during the dynamic digitalization of all spheres of society. The author's representation of society as an intellectual system of a high degree of complexity makes it possible to comprehend the concepts of reason and intelligence in connection with the development and implementation of artificial intelligence systems. Of particular interest is the disclosure by the authors of the potential of philosophical tools in countering manipulative technologies in the digital environment. The monograph is recommended to readers interested in achieving an understanding of the essence of digitalization processes, philosophical foundations and prospects for the development of technical intelligent systems.
A new view on corneal crosslinking and its application in ophthalmology
Authors:   National Medical and Surgical Center named after N.I. Pirogov, Moscow , Russian Federation, Kornilovsk I.M. , Gilya A.P. ,   National Medical and Surgical Center named after N.I. Pirogov, Moscow , Russian Federation, Khatataev R.R. ,   National Medical and Surgical Center named after N.I. Pirogov, Moscow , Russian Federation
Published: June 2022

The accumulated experimental and clinical data on corneal crosslinking made it possible to take a different look at the possibilities of its use for therapeutic and prophylactic purposes in various ophthalmic pathologies. Purpose. To consider new approaches to corneal crosslinking, criteria for its evaluation and expansion of the range of its applications in ophthalmology. Material and methods. Eight-year experimental (20 porcine eyes, 90 rabbit eyes) and clinical studies (610 surgeries) on photorefractive and phototherapeutic surgeries with saturation of the corneal stroma with riboflavin during laser correction of ametropias and the treatment of various diseases of the cornea were analyzed. A comprehensive examination was carried out using modern diagnostic devices. Particular emphasis was placed on the technique of two-wavelength optical scanning of the cornea. Results. Experimental and clinical studies have shown the benefits of corneal photoablation with riboflavin. The use of an ultrasonic nebulizer and isotonic 0.25% riboflavin solution cooled to +5–7°С provided the effect of local aeration and hypothermia. Such technology did not affect the accuracy of refractive ablation and blocked the negative effect of induced secondary radiation on keratocytes, nerves, and the underlying layers of the cornea. This reduced the aseptic in flammatory response and the risk of developing an irreversible form of fibroplasia. Ablation with riboflavin initiated a fading effect of crosslinking. Such prophylactic crosslinking in excimer laser surgery of the cornea proved to be sufficient to compensate for the weakening of its strength and photoprotective properties. These studies predetermined the development of a new technology of therapeutic crosslinking with riboflavin activation by subablative radiation of an argon-fluorine excimer laser for keratoectasias and other pathologies of the cornea. According to OCT and densitometry, all the classic signs of traditional crosslinking were noted. Two-wavelength optical scanning of the cornea revealed the effect of dehydration and an increase in the refractive index of the cornea, which can be considered as one of the objective criteria for assessing crosslinking. Conclusion. Crosslinking of the cornea with argon-fluorine excimer laser radiation in ablative and subablative modes expands the range of its application for the prevention of fibroplasia, keratoectasia during photorefractive, phototherapeutic ablation, treatment of keratoconus, secondary keratoectasias and other diseases of the cornea. Key words: crosslinking, cornea, photorefractive and phototherapeutic keratoablation, keratoconus, secondary kertoectasias, corneal pathology
Features of morphological changes in conjunctival biopsies after femtosecond laser
Authors:   Ufa Eye Research Institute, Ufa, Russian Federation, Kazakbaev R.A. , Surkova V.K. ,   Ufa Eye Research Institute, Ufa, Russian Federation, Muslimov S.A. ,   Russian Center for Eye and Plastic Surgery of Bashkir State Medical University, Ufa, Russian Federation, Halimov A.R. ,   Ufa Eye Research Institute, Ufa, Russian Federation
Published: June 2022

Purpose. To give a morphological assessment of human conjunctival biopsies obtained manually and using a femtosecond laser. Material and methods. Morphological studies were carried out in 4 groups of patients with pterygium who underwent autoplasty with a bulbar conjunctival flap. In groups 1–3 conjunctival biopsies with a thickness of 70, 80 and 100 microns respectively, were obtained using a femtosecond laser, in group 4 – a flap of the minimum possible thickness was cut out manually. Conventional methods of preparing histopreparations with hematoxylin-eosin staining and the Van Gieson method were used. Results. A feature of the manual technique for preparing a conjunctival graft is the formation of a flap with insufficiently smooth edges, uneven and unpredictable thickness. In the structure of such biopsies, violations of the continuity of cell layers, areas of epithelial rupture were noted. During the formation of a flap with a thickness of 80 and 100 microns using a femtolaser, morphological changes were noted in the form of destruction of epithelial cells, the appearance of foci of coagulation in the epithelial layer and cavitation vesicles in the connective tissue stroma. The severity of pathological changes increased as the depth of the conjunctival incision increased, which may be due to the use of a higher power of the femtolaser for this purpose. The smallest pathohistological changes in the conjunctival biopsies of the eyeball were observed when receiving a femto flap 70 microns thick. Conclusion. The use of various methods (manual technique or femtolaser) for obtaining a conjunctival transplant does not exclude the use of each of them in practical medicine. The femtolaserassisted technique makes it possible to obtain ultra-thin flaps that can be fixed seamlessly, in particular with fibrin glue. Key words: conjunctival biopsy, morphological examination, femtosecond laser, pterygium
The role of educational cycles in the training of vitreoretinal surgeons to work with severe posterior eye pathology
Authors:   Republican Clinical Ophthalmologic Hospital of the Ministry of Healthcare of the Chuvash Republic, Cheboksary, Russian Federation, Arsiutov D.G. ,   The Chuvash State University named after I.N. Ulyanov, Cheboksary, Russian Federation,   Postgraduate Doctors’ Training Institute of Health Care Ministry of Chuvashia, Cheboksary, Russian Federation, Samoylov A.N. ,   Kazan State Medical University of the Ministry of Healthcare of the Russian Federation, Kazan, Russian Federation,   State Autonomous Educational Institution Republican Clinic al Ophthalmologic al Hospital of the Ministr y of Healthcare of The Republic of Tatarstan, Kazan, Russian Federation
Published: June 2022

Purpose. To analyze the ten-year experience of the WetLab educational course on vitreoretinal surgery in Kazan, to evaluate the effectiveness of a multi-stage approach in the training of vitreoretinal surgeons to work with severe pathology of the posterior segment of the eye. Material and methods. Since 2011, 210 doctors from 47 regions of the Russian Federation and 5 neighboring countries completed the WetLab educational course in Kazan. C 25 courses have been conducted. After completing the course, the trainees participated in various seminars and master classes on vitreoretinal surgery, an individual training and mentoring program was organized. Results. More than 80% of the students, within 2 years after completing their studies on the main course and subsequent participation in additional educational activities, began to independently perform vitreoretinal surgeries. More than 50% of graduates today know all the main methods of modern vitreoretinal interventions. Conclusion. The effectiveness of multi-stage training of vitreoretinal surgeons is shown. Multi-stage training includes at the first stage a basic theoretical course and practicing practical skills within the WetLab program, at the second stage – participation in specialized seminars and master classes, supervision of a graduate of the course by a teacher-mentor according to an individual program. Such a training system for vitreoretinal surgeons allows about 80% of those who have completed training to start independent work after training. Key words: vitreoretinal surgery, ophthalmology, training, WetLab
A rare case of macular telangiectasia in a child
Authors:   Ufa Eye Research Institute, Ufa, Russian Federation, Miniazeva L.A. , Kazakbaeva G.M. ,   Ufa Eye Research Institute, Ufa, Russian Federation
Published: June 2022

Macular telangiectasia type 1 is usually characterized by a slowly progressive decrease in visual acuity in the 3–4 decade of life. Although MacTel usually manifests with a slowly progressive decrease in visual acuity in the fifth to seventh decades of life, younger patients may occasionally be diagnosed with the disease. Purpose. To present a clinical case of macular telangiectasia type 1 in an 8-year-old child. Material and methods. During a screening examination in one of the schools in the Kirovsky district of Ufa, an 8-year-old child was diagnosed with low vision in his left eye. The examination included a standard ophthalmological examination, as well as optical coherence tomography technology (Triton Topcon, Nidek Mirante, Japan). Fundus photography was performed on a Visucam fundus camera (Zeiss, Germany). Results. The left eye fundus showed microaneurysms, macular edema in the macular zone. According to OCT and OCT with laser scanning ophthalmoscopy, pathological changes in retinal structures were noted in the form of multiple cystic cavities of the neuroepithelium, deposits of small hyperreflective inclusions, intraretinal aneurysmal structures and violations of microangioarchitectonics and hypoperfusion zones. Conclusion. The clinical case demonstrates a rare form of macular telangiectasia type 1 in a child, complicated by cystic macular edema. For the diagnosis and monitoring of this disease, the use of optical coherence tomography with angio-mode is optimal, which is especially import ant when used in children. Key words: macular telangiectasia, OCT, macular edema, child
The efficacy of anti-vegf therapy in vitrectomized eyes with diabetic macular edema: a literature revue
Authors:   IRTC Eye Microsurgery Ekaterinburg Center, Ekaterinburg, Kazaykin V.N.
Published: June 2022

Diabetic macular edema (DME) is a serious vision threating disease in patients with diabetes mellitus. The introduction of antivasoproliferative therapy (anti-VEGF) into ophthalmic practice allowed patients not only to maintain, but also significantly improve visual acuity. Patients with DME may also have ophthalmic complications that require surgery, such as 3-port pars plana vitrectomy. According to some data, at the time of the start of antiangiogenic therapy, 4.5% of patients with DMO have undegone vitrectomy. It is widely known that changing the environment in the vitreous cavity can have a significant impact on the pharmacokinetic parameters of angiogenesis inhibitors, and therefore affect their effectiveness in patients after vitrectomy. In this regard, the question arises concerning the effectiveness of the use of anti-VEGF drugs in vitrectomized eyes. The literature review contains current data from both pharmacokinetic studies of anti-VEGF drugs in animal models with vitrectomized eyes and clinical studies of antivasoproliferative therapy in patients with DME after vitrectomy. Key words: vitrectomy; diabetic macular edema; anti-VEGF; pharmacokinetics; aflibercept; ranibizumab; vitrectomized eyes.
The development and clinical approbation of a brief interactive questionnaire assessing the treatment satisfaction of patients with macular diseases receiving anti-vegf therapy
Authors:   Ural State Medical University, Yekaterinburg, Bobykin E.V. , Morozova O.V. ,   Ural State Medical University, Yekaterinburg, Krokhalev V.Y. ,   Ural State Medical University, Yekaterinburg
Published: June 2022

Aim. Development and clinical approbation of a brief version of a questionnaire which allows to assess the level of treatment satisfaction (TS) of patients with macular diseases receiving anti-VEGF therapy. Methods. A questionnaire was proposed including 5 questions assessed on a scale from 0 to 6 points. A survey was conducted for patients with neovascular age-related macular degeneration who received anti-VEGF therapy (ranibizumab, aflibercept) and were divided into subgroups with low (n = 18) and high (n = 17) levels of compliance. Results. A statistically direct relationship between the levels of TS and compliance has been established and confirmed. A scheme for choosing an anti-VEGF therapy regimen for patients with different levels of TS has been proposed. Conclusion. The developed questionnaire takes into account the nuances of anti-VEGF therapy and can be used to determine the optimal treatment regimen for a particular patient. Key words: treatment satisfaction; questionnaire; anti-VEGF therapy; neovascular age-related macular degeneration; treatment regimen.
Comparative efficacy and safety of ranibizumab and aflibercept in the treatment of neovascular amd in combination with cataract surgery
Authors:   South Ural State Medical University, Chelyabinsk, Drozdova E.A. , Kuznetsov A.A. ,   Chelyabinsk Regional Clinical Hospital, Chelyabinsk
Published: June 2022

Aim. To perform a comparative analysis of the safety and efficacy of intravitreal injection (IVI) of ranibizumab and aflibercept with simultaneous phacoemulsification of cataract (FEC) and implantation of an intraocular lens (IOL) in patients with a combination of neovascular AMD and senile cataract. Methods. A comparative study was performed in 52 patients. IVI of ranibizumab and aflibercept was carried out by random sampling. Methods of clinical, OCT morphometric and immunological examination of tear in dynamics were used. Results. On the 31st day of follow-up, there was an increase in BCVA by an average of 3 lines, a decrease in the thickness of the retina in the macula the height and extent of subretinal fluid and pigment epithelium detachment, according to OCT. A decrease in the concentration of VEGF and TNFαwas detected in the tear. There was no statistically significant difference between ranibizumab and aflibercept. Conclusion. Simultaneous cataract surgery and administration of anti-VEGF drugs is an effective and safe method of treatment in patients with combined pathology. Key words: cataract surgery; neovascular age-related macular degeneration; anti-VEGF drugs; ranibizumab; aflibercept.
Results of surgical treatment of concomitant strabismus in adults on an outpatient basis
Authors:   Medical Organization “Optic-Center”, Chelyabinsk, Koshevarova A.R. , Nevstrueva A.O. ,   Medical Organization “Optic-Center”, Chelyabinsk, Berdnikova E.V. ,   South Ural State Medical University, Chelaybinsk
Published: June 2022

Aim. To evaluate the effectiveness of surgical treatment of concomitant strabismus in adult patients on an outpatient basis. Methods. 73 patients (73 eyes) with a diagnosis of concomitant strabismus without a paralytic component, aged from 19 to 62 years, were under observation. All patients underwent surgical treatment of strabismus for cosmetic purposes. Results. A decrease in the deviation angle was achieved in all patients. The state of orthotropy was obtained in 58 (79.5 %) patients. Conclusions. Surgical treatment of strabismus makes it possible to achieve the correct position of the eyeballs and a good cosmetic effect in 80 % of cases with a one-stage intervention and 94.5 % with a phased surgical treatment. Observation of patients in the long term (3 years) revealed a fairly persistent cosmetic effect of the intervention. Key words: strabismus in adults; strabismus surgery.
A computer program of patient examination for myopia follow-up
Authors:   Tashkent State Dental Institute, Tashkent, Uzbekistan, Kuryazova Z.K. , Yangieva N.R. ,   Tashkent State Dental Institute, Tashkent, Uzbekistan
Published: June 2022

Considering high prevalence of myopia, confirmed by the WHO report, and the level of disability, an electronic program for examining the patient and evaluation criteria were developed. An electronic program connected to a cellular communication system allows the user of the program to determine the degree of risk of myopia and its complications, as well as to receive recommendations for their prevention. Key words: myopia; clinical examination; electronic examination program.
Scientific substantiation of the concept of immediate sequential bilateral cataract surgery from the position of the “cascade” scheme tested in ophthalmology
Authors:   Federal State Autonomous Educational Institution of Higher Education “Russian Research Medical University named after N. I. Pirogov” of the Ministry of Health of Russia, Moscow, Medvedev I.B. , Pokrovsky D.F. ,   Federal State Autonomous Educational Institution of Higher Education “Russian Research Medical University named after N. I. Pirogov” of the Ministry of Health of Russia, Moscow
Published: June 2022

Aim. Scientific substantiation of the concept of conducting immediate sequential bilateral cataract surgery (ISBCS). Methods. As a basic concept, a conceptual model of excimer- and femtolaser impact on the organ of vision tested in ophthalmology was used, reflecting acute and long-term changes in the state of vision from clinical, functional and professional positions. Results. The block diagram includes three “cascades” – “damage”, “a priori measures” and “prevention of developing disorders”. Conclusions. The proposed scheme can be the basis for the development of new or improvement of existing areas of medical measures aimed at improving the safety and efficiency of the ISBCS. Key words: cataract; immediate sequential bilateral cataract surgery.
Efficacy of bimanual surgical treatment of retinal detachment in severe forms of proliferative diabetic retinopathy with preoperative preparation with anti-vegf drugs in combination with the use of 3d imaging system
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, Novosibirsk Branch, Novosibirsk, Chernykh D.V.
Published: June 2022

As a result of the study, it was found that visual acuity before the treatment was 0.03 [0.01; 0.1], and 4–6 months after the surgical treatment, 0.3 [0.15; 0.5]. The performed statistical analysis made it possible to establish a statistically significant increase in visual acuity 4–6 months after the treatment (p = 0.001) Complete anatomical retinal attachment with increased visual acuity was achieved. There were 5 complications in the postoperative period. Recurrent hemophthalmos was diagnosed in 3 cases, which required repeated surgical intervention. In 2 patients diabetic macular edema (DME) has developed, which required intravitreal injection of biodegradable dexamethasone implant. Key words: proliferative diabetic retinopathy; vitrectomy; 3D imaging; bimanual surgery; anti-VEGF drugs.
Mental Health and Its Risk Factors in Community Elderly with Chronic Non-Communicable Diseases
Authors:   Department of Epidemiology and Health Statistics, School of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Guizhou Medical University, Guiyang 550025, China, Xu Yueyao , Zhong Linzhe ,   The Madeira School, McLean, Virginia 22102, USA, Jiao Huiyan ,   Community Health Service Center of Shuangbei, Shapingba District, Chongqing 400032, China
Published: June 2022

Background: Understanding the mental health status of the elderly with chronic non-communicable diseases (CNCDs) in community and analyzing its related factors are essential for improving the quality of life of the elderly. Methods: A cross-sectional study was designed, and a face-to-face questionnaire survey was conducted to collect basic information, personal health status and lifestyle. Mental health status was assessed using the Depression Anxiety Stress Scale-21 (DASS-21). A multivariate logistic regression was used to evaluate the factors associated with mental health. Results: The abnormal rate of general mental health status in the elderly with CNCDs was 26.16%. Specifically, the prevalence of depression, anxiety, and stress symptoms was 11.39%, 19.83%, and 7.59%, respectively. Sleep disorder was an independent risk factor for depression, anxiety, stress and general abnormal mental health status (odds ratios (ORs): 2.99, 4.61, 10.78 and 4.14, respectively). Sedentary time was independently associated with general abnormal mental health status with an OR 2.33 for sedentary time>4 hours per day. Drinking was independently associated with depression (OR: 5.51). Women elderly had higher risk for general abnormal mental health status with an OR of 3.23. Conclusions: Drinking, sedentary lifestyle, sleep disorders and female were potential independent risk factor for abnormal mental health in the elderly with CNCDs. Our findings may lay the foundation for future interventions.
Electrocatalytic Hydrogen Evolution Reaction by a Molecular Ni Complex
Authors: Dressel Julia , Hooe Shelby , Moreno Juan , Dickie Diane , Machan Charles
Published: June 2022

In the face of rising atmospheric carbon dioxide (CO2) emissions from fossil fuel combustion, the hydrogen evolution reaction (HER) continues to attract attention as a method for generating a carbon-neutral energy source for use in fuel cells. Since some of the best-known catalysts use precious metals like platinum, which have low natural abundance and high cost, developing efficient Earth abundant transition metal catalysts for HER is an important objective. Building off previous work with transition metal catalysts bearing 2,2'-bipyridine-based ligand frameworks, this work reports the electrochemical analysis of a molecular nickel(II) complex, which can act as an electrocatalyst for the HER with a Faradaic efficiency for H2 of 94 ± 8% and turnover frequencies of 103±6 s−1 when pentafluorophenol is used as a proton donor. Computational studies of the Ni catalyst suggest that non-covalent interactions between the proton donor and ligand heteroatoms are relevant to the mechanism for electrocatalytic HER.
Novel organic electrode material for LIBs
Authors: Ng San Chong , Chan Ka Hei , Chen Janelle Camille Shi , Sou Choi Ngo
Published: June 2022

A novel organic electrode material (PGC) was developed through a facile copolymerization of polyethyleneimine (PEI), gallic acid (GA) and Cu2+ (CuCl2). PGC shows strong adhesion and numerous reaction sites in the microstructure due to the multiple phenolic hydroxyl groups of GA. When Cu2+ was copolymerized with PEI-GA, the final product features extremely high stability, durability, capacity, and efficiency, enhancing the electrochemical performance of batteries. Through the adjustment of the polymerization method, the reaction mechanism of PGC has been obtained. Eventually, it was observed that LEDs could be lit successfully by using the LIBs coin cells made of PGC, revealing that the PGC’s LIBs could have been applied to simple devices. It may provide a significant basis for the design of organic electrode materials in the future.
Computer Vision for Understanding Catalyst Degradation Kinetics
Authors: Yan Chunhui , Cowie Megan , Howcutt Calum , Wheelhouse Katherine , Hodnett Neil , Kollie Martin , Gildea Martin , Goodfellow Martin , Reid Marc
Published: June 2022

We report a computer vision strategy for the extraction and colorimetric analysis of catalyst degradation and product formation kinetics from video footage. The degradation of palladium(II) pre-catalyst systems to form ‘Pd black’ is investigated as a widely relevant case study for catalysis and materials chemistries. Beyond the study of catalysts in isolation, investigation of Pd-catalyzed Miyaura borylation reactions revealed informative correlations between colour parameters (most notably ΔE, a colour-agnostic measure of contrast change) and the concentration of product measured by off-line analysis (NMR and LC-MS). The breakdown of such correlations helped inform conditions under which reaction vessels were compromised by air ingress. These findings present opportunities to expand the toolbox of non-invasive analytical techniques, operationally cheaper and simpler to implement than common spectroscopic methods. The approach introduces the capability of analyzing the macroscopic ‘bulk’ for the study of reaction kinetics in complex mixtures, in complement to the more common study of microscopic and molecular specifics.
A New Weighted Associative Classifier Based on Nature Language Processing and Its Application in Chemical Data Mining
Authors: Yu Pulan
Published: June 2022

Associative classification mining (ACM) integrating association rule mining and classification has become a significant tool for knowledge discovery, especially in the chemical domain. Its major advantage is providing high accuracy as well as chemically interpretable models. Additionally, it is able to find associations among features while other traditional methods such as decision tree and naïve Bayesian consider the features independent to each other. In this paper, we propose a new weight framework for ACM based on information gain and graph theory. Combing this new scheme with CBA (classification based on associations), a novel classifier—IGAC (information gain and graph based associative classifier) is implemented and applied to three chemical datasets. In the generated models, the importance of the features related to the observed label classes is considered. The results show that not only IGAC can produce high accuracy (above 90%) but also the resulted models can be relatively easily interpreted by chemical knowledge. In addition, IGAC can discover meaningful rules which cannot be identified by classical associative classification mining (ACM).
ECONOMIC CRISIS IN RUSSIA
Authors: Lekomtsev-Kataev Kirill , Shumilina Vera
Published: June 2022

This article describes the current economic situation in the country. What forecasts do analysts give for the economic future of Russia. Why in Russia there will soon be a decline in production. And how the State supports small and medium-sized businesses in the context of the imposed sanctions
Shexian Bupleurum Alleviates Insomnia and Improves Symptoms of Anxiety and Depression: A Randomized Double-Blind Placebo-Controlled Clinical Trial
Authors: Zhang Kai , Zheng Xianling , Zhang Hongfeng , Zhang Xueqiang , Xu Yanmin , Jin Shiying , Huo Shuang
Published: June 2022

Objective: To observe the clinical efficacy of Shexian bupleurum on insomnia based on evaluation scales and polysomnogram (PSG). Methods: A total of 260 patients suffering from insomnia admitted to the outpatient department of Handan Central Hospital were included in a randomized, double blind, placebo-controlled trial. The patients were randomly divided into two groups: a control group (receiving placebo, n = 150), and an intervention group (receiving Shexian bupleurum treatment, n = 110). The clinical trial lasted for 4 weeks. The Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), Patient Health Questionnaire (PHQ)-9, Generalized Anxiety Disorder (GAD)-7, 17 items of Hamilton Depression Scale (HAMD-17), and Hamilton Anxiety Scale (HAMA) were used to evaluate the patients at baseline as well as two weeks and four weeks after treatment; the Treatment Emergent Symptom Scale (TESS) was used to evaluate adverse reactions; polysomnography (PSG) was used to monitor and analyze their sleep characteristics at baseline and four weeks after treatment. Results: The PSQI, ISI, PHQ-9, HAMD-17, and HAMA scores of the intervention group significantly decreased compared to the control group, while the total sleep time, rapid eye movement sleep latency, stage 2 sleep, deep sleep, rapid eye movement sleep, and sleep efficiency of the intervention group significantly increased compared to the control group. The PHQ-9 score of the control group only decreased two weeks after treatment (p < 0.05) compared to the intervention group. In addition, there were no obvious adverse events in both the intervention group and the control group. Conclusion: Shexian bupleurum not only improves sleep quality, but also relieves depression and anxiety in patients who suffer from insomnia.
Perspectivas musicais e pedagógicas nas memórias de Maria Yêda Caddah
Authors: Melo Rodrigo Alves de , Monti Ednardo Monteiro Gonzaga do
Published: June 2022

O presente trabalho é um recorte de uma Tese de Doutorado em andamento e tem como foco conhecer as memórias e histórias formativas da pianista e professora de música piauiense Maria Yeda Caddah e pretendemos assim, contribuir com a História da Educação e em especial, com a História da Educação Musical. Buscamos entender como suas viagens formativas influenciaram em sua atuação, enquanto artista e docente. As perguntas norteadoras deste estudo foram: Quando a pianista começou a fazer viagens para outros estados, com o intuito de estudar música? Quais a suas dificuldades nessa trajetória de se tornar docente? Qual a influência de sua participação em concursos de piano em sua prática pedagógica? Como a formação adquirida impactou em sua atuação docente?  A partir dos referenciais teóricos de Bourdieu (2006), Ferro (2010), Rocha (2012), Monti (2015), entre outro que discorrem sobre história e memória, educação e história, viagens de formação e trajetórias docentes, buscamos interpretar as contribuições desta pianista para a História da Educação Musical.