bluuebunny/crossref_metadata_2025 huggingface dataset:
Valued technical and non-technical skills among disaster responders: a cross sectional study of disaster responders involved in the earthquake in Türkiye and Syria January 2023
Authors: Westman Anja , Kurland Lisa , Hugelius Karin
Published: September 2024

Introduction

Disaster responders are an important part of disaster response. However, despite large efforts to train disaster responders, there is a limited scientific knowledge regarding which competences and skills such responders value and lack during a real mission. The aim of this study was to investigate used and needed skills among disaster responders responding to the earthquake in Türkiye and Syria 2023

Methods

A cross-sectional study using a non-randomized sample was conducted, collected between March and July, 2023. The participants were recruited through invitations distributed to international organizations, and the data were gathered through a web-based survey. The data were analyzed using descriptive and comparative statistics.

Results

A total of 525 participants involved in the disaster response in Türkiye or Syria in February 2023 were included. The most common valued skills were teamwork skills (n = 252, 59%), technical knowledge (n = 204, 48%), leadership skills (n = 105, 24%) and communication skills (n = 114, 17%). Women valued stress management (n = 33, 26%) more than leadership (n = 24, 19%) Technical knowledges were more valued among first-time responders (n = 168, 82%) compared to experienced responders (n = 108, 54%, p-value < 0.001). The most reported lacked skills were mental preparedness (n = 237, 53%), knowledge of the management system of international response (n = 132, 30%), stress management (n = 105, 24%) and leadership (n = 102, 23%).

Conclusion

The results showed slightly different needs in the various phases of a response, as well as some differences between men and women. Improving mental preparedness was not one of the most highly valued skills, but it was one of the skills that was most lacking; this discrepancy is an interesting finding. More in-depth analysis and additional studies are needed to further understand how best to prepare disaster responders and how their training can include the desirable skills. Further studies should be focused on the experience and knowledge of qualified disaster responders. This knowledge could also be of use when recruiting since several of the non-technical skills are not only gained solely through specific training.
Dental anxiety and dental care - a comparison between Albania and Germany
Authors: Cunoti Nertsa , Qorri Rezart , Irmscher Lisa , Qorri Erda , Magerfleisch Laura , Berth Hendrik
Published: September 2024

Background

The present study is the first in Albania on dental fear and dental anxiety and also in the field of psychosocial medicine. The purpose of this study was to find out whether there are differences in dental anxiety using the Dental Anxiety Scale, their level of psychological distress using the Brief Symptom Inventory-18 and the evaluation of oral health among Albanian and German patients.

Methods

This study was conducted in the period from December 2019 to July 2020, a sample of N = 263 patients (133 Germans, 130 Albanians) using the Dental Anxiety Scale questionnaires to determine anxiety before dental treatment and the Brief Symptom Inventory-18 to evaluate psychological distress. Moreover, the patients answered questions regarding their oral health and dental care. In Germany, there were four refusals to entrance in the study due to various reasons, in contrast to Albania, where there were no refusals at all For the purposes of this study, data on both populations aged 14 years and older were used.

Results

The questionnaires results were calculated for all participants. The current subjective health status of Albanian patients was assessed to be significantly worse than that of German patients (p < 0,000). Germans were more susceptible to signs of Anxiety (p < 0,000), Depression and Somatization and scored higher on the Dental Anxiety Scale and the Global Severity Index (p < 0,000) than Albanian patients. Additionally Albanian patients scored significantly lower on the preventive care index (p < 0,000). Despite an elevated DAS anxiety level, German patients reported going to the dentist more frequently than Albanian patients.

Conclusion

The results showed that between both populations differences in dental anxiety, psychological distress and oral health exists. Patients from Germany report more psychological distress and described more dental anxiety compared to Albanian patients. Albanian patients reported not utilization on oral health care.The implementation of educational programs and preventive measures, would contribute to raising awareness about the importance of oral health and increased use of dental services.
Development of a maturity model for demand and capacity management in healthcare
Authors: Myrberg Karin , Wiger Malin , Björkman Annica
Published: September 2024

Background

The aim of this paper is to develop a maturity model (MM) for demand and capacity management (DCM) processes in healthcare settings, which yields opportunities for organisations to diagnose their planning and production processes, identify gaps in their operations and evaluate improvements.

Methods

Informed by existing DCM maturity frameworks, qualitative research methods were used to develop the MM, including major adaptations and additions in the healthcare context. The development phases for maturity assessment models proposed by de Bruin et al. were used as a structure for the research procedure: (1) determination of scope, (2) design of a conceptual MM, (3) adjustments and population of the MM to the specific context and (4) test of construct and validity. An embedded single-case study was conducted for the latter two - four units divided into two hospitals with specialised outpatient care introducing a structured DCM work process. Data was collected through interviews, observations, field notes and document studies. Thematic analyses were carried out using a systematic combination of deductive and inductive analyses - an abductive approach - with the MM progressing with incremental modifications.

Results

We propose a five-stage MM with six categories for assessing healthcare DCM determined in relation to patient flows (vertical alignment) and organisational levels (horizontal alignment). Our application of this model to our specific case indicates its usefulness in evaluating DCM maturity. Specifically, it reveals that transitioning from service activities to a holistic focus on patient flows during the planning process is necessary to progress to more advanced stages.

Conclusion

In this paper, a model for assessing healthcare DCM and for creating roadmaps for improvements towards more mature levels has been developed and tested. To refine and finalise the model, we propose further evaluations of its usefulness and validity by including more contextual differences in patient demand and supply prerequisites.
Registered nurse case managers’ work experiences with a person-centered collaborative healthcare model: an interview study
Authors: Hjelm Markus , Andersson Anna , Ujkani Venera , Andersson Ewa Kazimiera
Published: September 2024

Background

Multimorbidity is increasingly acknowledged as a significant health concern, particularly among older individuals. It is associated with a decline in quality of life and psychosocial well-being as well as an increased risk of being referred to multiple healthcare providers, including more frequent admissions to emergency departments. Person-centered care interventions tailored to individuals with multimorbidity have shown promising results in improving patient outcomes. Research is needed to explore how work practices within integrated care models are experienced from Registered Nurse Case Managers’ (RNCMs) perspective to identify areas of improvement. Therefore, the aim of this study was to describe RNCMs’ work experience with a person-centered collaborative healthcare model (PCCHCM).

Methods

This study used an inductive design. The data were collected through individual interviews with 11 RNCMs and analyzed using qualitative content analysis.

Results

Data analysis resulted in four generic categories: ‘Being a detective, ‘Being a mediator’, ‘Being a partner’, and ‘Being a facilitator of development’ which formed the basis of the main category ‘Tailoring healthcare, and social services to safeguard the patient’s best.’ The findings showed that RNCMs strive to investigate, identify, and assess older persons’ needs for coordinated care. They worked closely with patients and their relatives to engage them in informed decision-making and to implement those decisions in a personalized agreement that served as the foundation for the care and social services provided. Additionally, the RNCMs acted as facilitators of the development of the PCCHCM, improving collaboration with other healthcare professionals and enhancing the possibility of securing the best care for the patient.

Conclusions

The results of this study demonstrated that RNCMs tailor healthcare and social services to provide care in various situations, adhering to person-centered care principles and continuity of care. The findings underline the importance of implementing integrated care models that consider the unique characteristics of each care context and adapt different case managers’ roles based on the patient’s individual needs as well as on the specific needs of the local setting. More research is needed from the patients’ and their relatives’ perspectives to deepen the understanding of the PCCHCM concerning its ability to provide involvement, security, and coordination of care.
Comparative effects of curcumin, nano curcumin and their combination on reproductive traits and spawning performance of red tilapia (Oreochromis Niloticus X O. Mossambicus)
Authors: Eissa El-Sayed Hemdan , Hendam Basma M. , Dighiesh Hagar Sedeek , Abd Elnabi Heba E. , Abd El-Aziz Yasmin M. , Eissa Moaheda E. H. , Abdelnour Sameh A. , Ghanem Sara F.
Published: September 2024

Curcumin, the main polyphenol component of turmeric powder, has garnered increasing attention as an effective supplement in fish diets. A comparative trial was conducted to evaluate the impacts of dietary supplementation with different forms of curcumin (free, in combination, or nanoparticles) on hemato-biochemical parameters, reproductive capacity, and related gene expressions of red tilapia (Oreochromis niloticus x O. mossambicus) broodstock. Fish (n = 168) were fed an isonitrogenous (30% CP), isocaloric (18.72 MJ kg − 1) diet containing basal diet (Control), 60 mg kg-1 of either free curcumin (Cur), curcumin/nano-curcumin blend (Cur/NCur), or nano-curcumin (NCur) for 56 days. Red tilapia broodstock (155 ± 5.65 g) were stocked at a male: female ratio of 1:3. Blood samples and gonads were collected to assess hemato-biochemical parameters, reproductive capacity, and related gene expression at the end of the feeding trial. The results indicated that the values of hematological parameters (RBCs, WBCs, hemoglobin), total protein, albumin values, and reproductive hormones (T, LH, and FSH) were significantly increased, while liver function enzymes were decreased in the NCur group (P < 0.05). Reproductive performances (GSI, gonad maturation, total number of fry per female) were significantly improved in the NCur group compared with those in other groups (p < 0.05). The expression of reproductive genes (CYP19A1A, FSHR, LHR, FOXL2A, ESR1, ESR2A, and PGR) were significantly up‐regulated in the gonads of fish fed NCur. Collectively, feeding red tilapia diets containing NCur led to noticeably better results followed by Cur/NCur blend, then free Cur compared to the control diet. These results indicate the superiority of NCur over its free or blended form, suggesting that a diet containing about 60 mg/kg of NCur is beneficial for enhancing hemato-biochemical parameters, improving reproductive performance, and enhancing the gonadal architecture of red tilapia.
Functional benefit of joint surgery in patients with non-vascular Ehlers-Danlos syndrome: results of a retrospective study
Authors: Abihssira Sharon , Benistan Karelle , Nourissat Geoffroy
Published: September 2024

Background

Ehlers-Danlos syndrome (EDS) is a hereditary disease characterised by joint hypermobility, skin hyperextensibility and tissue fragility. Hypermobile EDS (hEDS is the more frequent subtype. Joint surgery may benefit certain patients after failure of medical treatments, but there is no consensus on the optimal surgical management of patients with hEDS. The aims of this retrospective study were to chart the surgical management of patients with hEDS, to determine the role of arthroscopy and to evaluate the functional results of joint surgery, including the reintervention rates.

Results

A total of 69 patients with non-vascular EDS were evaluated (60 female; 87%). Mean (SD) age at first surgery was 25.6 ± 11.1 years. Among the 69 patients, first surgeries were carried out on the knee (n = 50; 39.4%), ankle (n = 28; 22.0%), shoulder (n = 22; 17.3%), wrist (n = 18; 14.2%) and elbow (n = 9; 7.1%). One-fifth of all first operations (20.8%) were carried out by arthroscopy, most often on the knee (36% of knee surgery cases). At the time of primary surgery, the surgeon was alerted to the diagnosis or suspicion of hEDS in only 33.9% of patients. The rate of reoperations (2 to ≥ 5) was 35.7% (10/28) for the ankle, 40.9% (9/22) for the shoulder, 44.4% (4/9) for the elbow, 50% (9/18) for the wrist and 60% (30/50) for the knee. Local or regional anaesthesia was badly tolerated or ineffective in 27.8%, 36.4% and 66.6% of operations on the wrist, shoulder and elbow, respectively. Overall, the majority of patients (> 70%) were satisfied or very satisfied with their surgery, particularly on the non-dominant side. The lowest satisfaction rate was for shoulder surgery on the dominant side (58.3% dissatisfied).

Conclusions

Surgery for joint instability has a greater chance of success when it is carried out in patients with a known diagnosis of EDS before surgery. The majority of patients were satisfied with their surgery and, with the exception of the knee, there was a low rate of reoperations (≤ 50%). Arthroscopic procedures have an important role to play in these patients, particularly when surgery is performed on the knee.
Spontaneous hepatic hemorrhage as presentation of metastasized papillary thyroid carcinoma: a case report
Authors: Thomasson Jacob , Andersson Bodil , Thompson Lo Hallin , Williamsson Caroline
Published: September 2024

Background

Spontaneous hepatic hemorrhage is a rare condition, most commonly diagnosed in patients with hepatocellular carcinoma or hepatic adenomas, and is seldom caused by metastatic disease. In this case report, we present a patient with spontaneous hepatic hemorrhage due to hepatic metastasis of papillary thyroid carcinoma, an exceptionally rare occurrence.

Case presentation

The patient was a 77-year-old white male with a history of atrial fibrillation treated with apixaban. He presented at a local hospital with abdominal pain and nausea. A CT scan revealed a hepatic lesion in segment 3 with an adjacent hematoma. He was referred to our tertiary center and treated conservatively. Further evaluation revealed an intrathoracic goiter containing a tumorous process diagnosed as a papillary thyroid carcinoma (PTC), and the patient subsequently underwent thyroidectomy. A biopsy of the hepatic lesion confirmed it as a PTC metastasis. Due to worsening abdominal pain and anorexia, the patient underwent subacute hepatic segmental resection. Postoperatively, he developed iodine-refractory disease with disseminated metastasis and passed away 22 months after the initial admission.

Conclusions

To our knowledge, this is the first recorded case of metastasized papillary thyroid carcinoma presenting with spontaneous hepatic hemorrhage—adding to the list of rare causes for this condition.
Pain assessment from facial expression images utilizing Statistical Frei-Chen Mask (SFCM)-based features and DenseNet
Authors: Alphonse Sherly , Abinaya S. , Kumar Nishant
Published: September 2024

Estimating pain levels is crucial for patients with serious illnesses, those recovering from brain surgery, and those receiving intensive care etc. An automatic pain intensity estimator is proposed in this study that gathers information about pain and intensity from the user’s expressions. The faces in the database are first cropped using a ‘Chehra’ face detector, which performs well even in wildly uncontrolled environments with a wide range of lighting and position fluctuations. The suggested technique extracts the beneficial and distinct patterns from facial expressions using novel Statistical Frei-Chen Mask (SFCM)-based features and DenseNet-based features. As it offers quick as well as accurate pain identification and pain intensity estimation, the Radial Basis Function Based Extreme Learning Machine (RBF-ELM) is employed for pain recognition and pain intensity level estimation using the characteristics. All the data is kept, updated and protected in the cloud because availability and high-performance decision-making are so important for informing physicians and auxiliary IoT nodes (such as wearable sensors). In addition, cloud computing reduces the time complexity of the training phase of Machine Learning algorithms in situations where it is possible to build a complete cloud/edge architecture by allocating additional computational resources and memory in use. The facial expression images from the UNBC-McMaster Shoulder Pain Expression Archive and 2D face dataset are used to test the proposed method. The measurement of pain intensity uses four stages. When compared to the results from the literature, the proposed work attains enhanced performance.
Factors Influencing the Use of Evidence-based Instructional Practices by Community College Biology Instructors
Authors: Archie Tim , Wise Sarah B. , Robalino Javier , Chmiel Marjee , Laursen Sandra
Published: September 2024

CC biology instructors' beliefs, collegial support, and perceived knowledge of and skill in using evidence-based teaching practices (EBIPs) positively influence their use. Barriers to using EBIPs reported by CC instructors included the need to cover large amounts of course content, lack of time to prepare for using EBIPs, and student resistance.
Characteristics of high-dose benzodiazepine use: nationwide cohort study on new benzodiazepine users with 5-year follow-up
Authors: Särkilä Hanna , Taipale Heidi , Tanskanen Antti , Kurko Terhi , Taiminen Tero , Tiihonen Jari , Sund Reijo , Saastamoinen Leena , Hietala Jarmo , Niemelä Solja
Published: September 2024

Background

A nationwide register-based cohort study from Finland including 48 124 incident benzodiazepines and related drug (BZDR) users aged 18–65 years who initiated use in 2006 and were not dispensed BZDRs during 2004–2005. The follow-up was 5 years or until death, whichever occurred first.

Aims

To investigate sociodemographic and clinical factors associated with high-dose use of BZDRs (i.e. Z-drugs) among new BZDR users.

Method

The temporal BZDR dose was calculated as a point estimate every 6 months after initiation as defined daily doses (DDDs) per day, based on the PRE2DUP method (an approach based on mathematical modelling of personal drug purchasing behaviours). Sociodemographic and clinical factors associated with dose categories were studied using multinomial logistic regression.

Results

During the 5-year follow-up, very high-dose BZDR use was observed in 7.4% (n = 3557) and medium high-dose use in 25.5% (n = 12 266) of the users (corresponding to ≥30 mg and 10–29 mg in diazepam equivalents, respectively). Very high-dose use was more common among men compared with women (10.9% versus 4.6%). Very high-dose use patterns were especially observed in younger age groups (18- to 25-year-olds). Compared with oxazepam, initiating BZDR use with clonazepam (adjusted odds ratio 3.86, 95% CI 3.24–4.60), diazepam (2.05, 1.78–2.36) or alprazolam (1.76, 1.52–2.03) was associated with increased odds for very high-dose use. Both medium high-dose and very high-dose BZDR use were associated with a lower level of education. In all, 58% of very high-dose use occurred in BZDR users who received their first prescription from general practitioners.

Conclusions

Clinicians should be aware of the dose escalation risk especially when prescribing diazepam, alprazolam or clonazepam for psychiatric indications. If BZDRs are needed, our findings suggest favouring oxazepam.
A Data Portrait of Cisgender, Transgender, and Gender-Nonconforming Populations in the United States: A Research Note
Authors: Stacey Lawrence
Published: September 2024

The transgender population is a critically underresearched population in the United States, owing to rare measures on national and state-level surveys that ask about sex and gender or transgender identification. Consequently, we know relatively less about the sociodemographic, socioeconomic, family, and health lives of gender minorities. In this research note, I use population-level data from the Centers for Disease Control and Prevention’s Behavioral Risk Factor Surveillance System to provide a data portrait of cisgender, transgender, and gender-nonconforming populations on a range of sociodemographic (e.g., sexual identity, race and ethnicity), socioeconomic (e.g., education, homeownership), family (e.g., union status), and health (e.g., number of poor mental health days) characteristics. Results reveal that gender minorities are younger than cisgender men and cisgender women and are disproportionately sexual minorities and people of color. Gender minority groups also experience lower socioeconomic status, report drastically different family lives, and bear the burden of worse health compared with cisgender people. I conclude by contending that descriptive research of this nature can illuminate compositional differences between cisgender and gender minority populations, provide rationales for adjusting for certain characteristics, and highlight potential explanatory mechanisms to make better sense of well-established findings (e.g., the transgender health disadvantage).
Precision in situ cryogenic correlative light and electron microscopy of optogenetically positioned organelles
Authors: Tillu Vikas A. , Redpath Gregory M. I. , Rae James , Ruan Juanfang , Yao Yin , Cagigas Maria L. , Whan Renee , Hardeman Edna C. , Gunning Peter W. , Ananthanarayanan Vaishnavi , Parton Robert G. , Ariotti Nicholas
Published: September 2024

Unambiguous targeting of cellular structures for in situ cryo-electron microscopy in the heterogeneous, dense and compacted environment of the cytoplasm remains challenging. Here, we have developed a cryogenic correlative light and electron microscopy (cryo-CLEM) workflow that utilizes thin cells grown on a mechanically defined substratum for rapid analysis of organelles and macromolecular complexes by cryo-electron tomography (cryo-ET). We coupled these advancements with optogenetics to redistribute perinuclear-localised organelles to the cell periphery, allowing visualisation of organelles that would otherwise be positioned in cellular regions too thick for cryo-ET. This reliable and robust workflow allows for fast in situ analyses without the requirement for cryo-focused ion beam milling. Using this protocol, cells can be frozen, imaged by cryo-fluorescence microscopy and be ready for batch cryo-ET within a day.
Minimal Impact of Age on Adaptive Bone Formation in the Distal Tibia of US Army Basic Combat Trainees: The ARMI Study
Authors: Guerriere Katelyn I. , Hussian Ian M. , Bartlett Paul M. , Castellani Colleen M. , Walker Leila A. , Taylor Kathryn M. , Smith Nathaniel I. , Staab Jeffery S. , Pasiakos Stefan M. , Gaffney-Stomberg Erin , Popp Kristin L. , Bouxsein Mary L. , Fraley Amy L. , McClung James P. , Friedl Karl E. , Proctor Susan P. , Foulis Stephen A. , Hughes Julie M.
Published: September 2024

Introduction

Although bone formation has been observed in the distal tibia of trainees during Basic Combat Training (BCT), some animal studies have demonstrated greater mechanosensitivity in the juvenile compared to the mature skeleton. How age affects skeletal adaptations to military training is unknown. The purpose of this study was to determine if skeletal adaptations to US Army BCT differ by age.

Methods

We enrolled 2085 trainees (1303 males, 782 females). High-resolution peripheral quantitative computed tomography was used to assess total, cortical, and trabecular bone mineral density (BMD) and the microarchitecture of the distal tibia before and after 8 wk of BCT. Generalized linear models were used to compare mean percent change (95% confidence interval (CI)) in each bone parameter by age group (<20, 20–25, 26–29, and ≥30 yr) and to evaluate differences in bone parameter changes between age groups (effect estimates (95% CI)). Models were stratified by sex with multivariable adjustment.

Results

Male and female trainees in all age groups had increases in total BMD, trabecular BMD, and trabecular bone volume fraction from baseline (P < 0.01 for all). Male and female trainees also had increases in trabecular thickness from baseline in all groups (P < 0.05) except females ≥30 yr old. Female trainees 20–25 yr old had a significantly larger increase in trabecular thickness than those <20 yr old (effect estimate (95% CI), 0.33% (0.02%–0.64%); P < 0.05). Trabecular microarchitecture was largely not otherwise different between age groups for either sex. Male and female trainees <20 yr old had greater changes in cortical BMD compared to older age groups (males, P < 0.01; females, P < 0.05 for all).

Conclusion

Trainees <20 yr old experience the greatest improvements in cortical BMD at the distal tibia during US Army BCT, suggesting that adaptive bone formation in cortical bone may be attenuated with skeletal maturity. However, the mechanosensitivity of trabecular bone to exercise training remains intact regardless of age.
Mechanistic Insight into Physical Activity Pleiotropy in Cancer Prevention
Authors: Bullard Brooke M. , VanderVeen Brandon N. , Cardaci Thomas D. , Carson James A. , Murphy E. Angela
Published: September 2024

Although improvements in prevention and screening have curbed the incidence of some cancers, the global burden of cancer is substantial and continues to grow. The sustained high prevalence of many cancers reveals the need for additional strategies to reduce occurrence. Observational studies have linked physical inactivity to the risk of 13 different cancers. Indeed, physical activity can reduce the occurrence of several cancers by more than 20%, whereas sedentary behavior can increase cancer risk. Thus, physical activity presents a viable lifestyle intervention to reduce the global burden of cancer, and current research efforts are focused on establishing the effective physical activity mode and intensity for cancer prevention. Preclinical cancer studies have provided insight into the mechanisms mediating these effects. There is growing evidence that physical activity can 1) reduce the risk of obesity and, by extension, metabolic dysregulation; 2) improve immune surveillance and reduce inflammation; 3) enrich the colonic environment by favoring beneficial microbes and reducing transit time; and 4) regulate sex hormones. This graphical review describes the current state of knowledge on the benefits of physical activity for cancer prevention and associated plausible mechanisms.
Multisymptom Burden in Cancer Survivors: Benefits of Physical Activity
Authors: Cardaci Thomas D. , VanderVeen Brandon N. , Bullard Brooke M. , Carson James A. , Murphy E. Angela
Published: September 2024

In contrast with other leading causes of mortality, the cancer death rate in the United States continues to decline, reflecting improvements in prevention, screening, and treatment. Despite these advances, there has been limited development of strategies to counter the unwanted and debilitating effects associated with cancer and its treatments. Indeed, syndromes including cachexia, cardiotoxicity, fatigue, and mucositis among others plague cancer survivors, leading to poor life quality and premature mortality. The systemic nature of these impairments creates a strong rationale for treatment strategies to mitigate syndromes affecting cancer survivors. Currently, however, there are limited treatments approved by the US Food and Drug Administration to counter the debilitating side effects of cancer and cancer treatments. In noncancer clinical populations, physical activity is a well-established strategy to increase muscle mass, improve cardiovascular health, enhance energy levels, and promote gut health. Although physical activity programs are widely encouraged for cancer survivors, researchers are just beginning to understand the physiological basis of their positive effects and how they can be maximized for different cancer populations and treatments. This graphical review describes the benefits of physical activity and associated mechanisms for ameliorating select side effects of cancer and its therapeutics.
Οι άγιοι Τεσσαράκοντα μάρτυρες οι εν Σεβαστεία στη βυζαντινή υμνογραφική γραμματεία
Authors: Βαγενά-Παντούλα Άννα-Μαρία
Published: September 2024

Οι άγιοι Τεσσαράκοντα μάρτυρες ήταν στρατιωτικοί και έζησαν στην πόλη της Σεβαστείας (στον Πολεμωνιακό Πόντο, στη Β.Α. Μικρά Ασία). Μαρτύρησαν στις αρχές του 4ου αι. κατά τη διάρκεια του μεγάλου διωγμού του Λικινίου. Οι άγιοι εκλήθησαν από τον ηγεμόνα Αγρικόλαο και τον δούκα Λυσία στη Σεβάστεια, προκειμένου να απαρνηθούν την πίστη τους στον Χριστό. Επειδή δεν συμμορφώθηκαν με την απαίτηση του Αγρικόλαου και του Λυσία, διατάχθηκαν να παραμείνουν όλη τη νύχτα γυμνοί στην παγωμένη λίμνη. Αφού εξέπνευσαν από υποθερμία, τα σώματά τους στη συνέχεια κάηκαν, αλλά περιεσώθησαν κάποια λείψανα με θαυματουργικό τρόπο. Η τιμή τους διαδόθηκε από πολύ νωρίς στη Δύση και στην Ανατολή. Στόχος μου ήταν να εξετάσω, να μελετήσω και να αναλύσω το σύνολο των υμνογραφικών κειμένων που είναι αφιερωμένα στους αγίους Τεσσαράκοντα, να εκπονήσω την πρώτη κριτική έκδοση όλων των έως τώρα ανέκδοτων υμνογραφικών κειμένων αλλά και να επανεκδώσω τα ελλιπώς εκδεδομένα υμνογραφικά κείμενα Κατ᾽ αυτόν τον τρόπο συγκροτείται το συνολικό corpus της υμνογραφικής παράδοσης για τους αγίους, το οποίο παρά τις πολλές προηγηθείσες μελέτες για εκείνους, δεν είχε συγκροτηθεί μέχρι σήμερα.
Zaangażowanie, unikanie, odmowa współpracy. Marian Jurczyk wobec Służby Bezpieczeństwa (1977–1980)
Authors: Siedziako Michał
Published: September 2024

Artykuł omawia relacje jednego z późniejszych liderów NSZZ „Solidarność” Mariana Jurczyka ze Służbą Bezpieczeństwa, które miały miejsce latach siedemdziesiątych XX wieku. Policja polityczna inwigilowała wówczas środowisko byłych działaczy strajkowych z grudnia 1970 – stycznia 1971 r. w Stoczni Szczecińskiej, w tym Jurczyka. W ramach podejmowanych działań zbierano informacje o poszczególnych osobach i starano się kontrolować ich działania wymierzone przeciwko panującym realiom politycznym. Jurczyka zwerbowano do współpracy w 1977 r., faktycznie zakończyła się ona w 1979 r. Po raz ostatni próbowano skłonić go do kontaktów agenturalnych, kiedy stanął na czele strajków w Szczecinie latem 1980 r., ale po jego odmowie wyrejestrowano go z ewidencji SB w 1981 r.
Działalność Brytyjskiego i Zagranicznego Towarzystwa Biblijnego na ziemiach polskich (1816–1992). Rekonesans badawczy
Authors: Nalewajko-Kulikov Joanna
Published: September 2024

W 1816 r. powstał polski oddział Brytyjskiego i Zagranicznego Towarzystwa Biblijnego (British and Foreign Bible Society, BFBS) w Warszawie, którego zadaniem była dystrybucja Biblii katolickich i protestanckich w języku polskim. Funkcjonował on z przerwami przez cały XIX w., podlegając większym agencjom BFBS w Wiedniu lub w Petersburgu. Szerszą działalność rozwinął w okresie międzywojennym pod kierownictwem Aleksandra Enholca i po II wojnie światowej. Od 1967 r. kierowała nim Barbara Enholc-Narzyńska. W 1992 r. oddział formalnie się usamodzielnił i od tej pory działa jako Towarzystwo Biblijne w Polsce.
The Dark Side of Alcohol: Implications for Muscle Growth, mTOR Pathway, and Athletic Recovery
Authors: Dobosz Anna , Zduńczyk Wiktoria , Dubińska Michalina , Paduch-Jakubczyk Wiktoria , Bilska Wiktoria , Żydek Ada , Ciułek Urszula
Published: September 2024

Introduction and Objective: Alcohol is a prevalent substance in many cultures, often associated with socializing, relaxation, and even post-exercise rituals. Despite its widespread use, the effects of alcohol on muscle recovery and hypertrophy are not well understood by the general public. Emerging research suggests that alcohol may have negative health effects on these factors. Understanding the interaction between alcohol consumption and resistance training is crucial for athletes and individuals aiming to optimize their fitness outcomes.
The main aim of this article is to show clinicians, patients and, above all, athletes, the negative effects of alcohol on training and leading a healthy lifestyle.
Review and Methods: Review and summary of studies and meta-analysis of studies available in open-source format on Google Scholar, Web of Science and PubMed.
Abbreviated Description of the State of Knowledge: Resistance training is a proven method for increasing muscle mass and strength through the process of hypertrophy, where muscle protein synthesis (MPS) exceeds muscle protein breakdown (MPB). The mechanistic/mammalian target of rapamycin (mTOR) signaling pathway plays a key role in regulating MPS and hypertrophy. 
Summary: Alcohol has been shown to impair muscle protein synthesis, primarily through its negative effects on the mTOR signaling pathway, which is crucial for muscle growth. Additionally, alcohol disrupts sleep quality, further hindering recovery and performance.
Pharmacological Treatment of Obesity: A Review of Current and Future Methods
Authors: Lęgas Angelina , Smalira Joanna , Przybysz Bartosz , Kawalec Jakub , Zawistowska Julia , Rogowska Karolina , Pochodowicz Katarzyna , Rogala Weronika , Rutkowska-Kawalec Weronika , Urbańska Karolina
Published: September 2024

Introduction and objective
Obesity poses a significant public health challenge due to its association with an elevated risk of various chronic diseases, including cardiovascular conditions, type 2 diabetes, and overall mortality. While lifestyle modifications such as dietary changes and increased physical activity remain cornerstone interventions in obesity management, pharmacological treatments have emerged as an adjunctive approach to address this complex condition. The review aims to compare the effectiveness of current pharmacotherapy and show upcoming methods of treatment of obesity.

Review methods
The review was conducted by searching scientific publications in PubMed, Google Scholar, Clinicaltrials.gov, Summaries of Product Characteristics, URPL, FDA, and EMA databases. The articles on medications available in Poland for treating obesity and the latest clinical trials of upcoming drugs were analyzed, followed by a concise review of the collected data.

Abbreviated description of the state of knowledge
Currently, in the Polish market, medications available for obesity treatment include orlistat, the combination of naltrexone and bupropion, liraglutide, tirzepatide, and available as part of the target import - semaglutide. Promising clinical trials are being conducted on further medications for weight reduction, including retatrutide, orforglipron, cagrilintide, and amycretin. Regrettably, new and effective medications due to their high cost and insufficient funding.

Summary
New pharmacotherapy options for obesity, particularly anti-diabetic medications, are rapidly advancing. Glucagon-like peptide-1 (GLP-1) analogs have shown promising results in weight reduction, surpassing previous medications such as orlistat or naltrexone. Recent drugs offer weight loss ranging up to 25%. More studies are underway on novel and increasingly effective medications.
Impact of Physical Activity and Exercise on Endometriosis Related Symptoms with Particular Emphasis on Pain - Systematic Review
Authors: Kuśnierz Anna , Kusiak Karolina , Głąbień Marta , Miłkowski Paweł , Aleksandrowicz Daria , Wieczorek Olga , Jakubczak Zofia , Kondratowicz Aneta , Zimniak Maria Weronika , Śliwiak Patryk
Published: September 2024

Endometriosis is common chronic condition that can cause acute and chronic pain. It affects 5-10 % of women in their reproductive years. It is characterized by the presence of endometrial- like tissue outside the uterus and it is associated with pelvic pain and infertility. Diagnosis of endometriosis requires laparotomy or laparoscopy. Therefore, there is often a delay from initial symptoms to diagnosis and treatment. There is no effective treatment. Current therapeutic methods aim to reduce pain and treat infertility. It include surgery, hormonal treatments and analgesics in case of a pain. Additionally, this methods have their limitations in form of side effects and unsatisfactory therapeutic effect. [1,2] Wherefore physical activity (PA) and exercise have been suggested as alternative treatments.[3] In this study authors perform a systematic review to evaluate the effect of PA and exercise on endometriosis-related symptoms.
Case Article—Optimizing Transportation and Equity in a District Zoning Problem for ORville Public Schools
Authors: Sullivan Kelly M. , Bennett Milburn Ashlea
Published: September 2024

This case asks students to solve a multiobjective optimization decision problem applied to school district zoning. In the case, residential areas in a school district must be assigned to middle schools having capacity limits. The operational considerations on the decision are the weighted distances traveled between students’ residences and their assigned middle school campuses. The ethical considerations pertain to equity in education and are measured using the numbers of economically disadvantaged students assigned to each middle school. This problem, including its two objectives, is motivated by a real zoning problem faced by a school district. Publicly available data from the school district and its rezoning efforts are used to populate the case. To complete the case, students model and solve an optimization problem both with and without the ethical considerations included. In doing so, they observe how ethical considerations can change the outputs generated by the optimization model. Evidence is provided from student surveys to indicate how completion of the case impacts perceptions of the importance of and understanding of how to include ethical considerations in optimization modeling. Results indicate statistically significant increases in those perceptions.

Supplemental Material: The Teaching Note and DataAndMetricsDemo Excel workbook are available at https://www.informs.org/Publications/Subscribe/Access-Restricted-Materials .
Competence of Productive Teachers in Utilizing Learning Media Based on Information Communication Technology
Authors: Fachri Fandi Faisyal , Muchlas Muchlas , Santosa Budi
Published: September 2024

The ability of teachers to create ICT-based learning media is low, despite ICT's potential to address shortages in practical equipment and facilities. This research aims to analyze vocational high school teachers' competency in utilizing ICT-based learning media and identify obstacles they face. Using a descriptive qualitative method, the study involves productive teachers, school principals, and heads of administration. It focuses on teachers with expertise in broadcasting, film, animation, and machining techniques. The research steps include problem identification, limitation, focus determination, data collection, analysis, and reporting. Findings reveal that the average competency of productive teachers in three vocational schools is good: 35.29% are at a basic level, 47.06% at intermediate, and 17.65% at advanced. Teachers learn to create ICT-based media through lectures (10 teachers), courses (6), workshops (14), training (10), and independently (3), with workshops being the most common. In practical learning, 100% of teachers use PowerPoint, 64.71% use animation, 23.53% use Moodle, and 5.88% each use Debian, Nginx, and PHP. Barriers include lack of facilities (17.65%), ICT mastery (17.65%), time (31.18%), and other reasons (23.53%).
Use of Digital Learning Management Systems for Enhancing Cognitive Achievement in Vocational Productive Course
Authors: Suryantoro Sigit Arif , Muchlas Muchlas , Santosa Budi
Published: September 2024

The use of digital technology is increasingly widespread, including in the world of education. Observations in the field found that students' understanding of using digital technology to support learning productive lessons in vocational high schools still needed to improve. The study aims to obtain information about (1) the level of students' understanding of the use of digital learning management systems (DLMS); (2) the level of student perception regarding the availability and quality of DLMS use, and (3) the effectiveness of DLMS implementation in increasing students' understanding of productive subjects. This research is a quantitative study with a proportional random sampling technique. The sample was 194 out of 441 students from three state-owned vocational high schools. Data was collected using questionnaire instruments, observation sheets, and documentation. Data credibility is measured using validity, reliability, normality, and homogeneity tests, while data processing techniques use partial significance tests (t-test) and simultaneous tests (F-test). The research results show that students' understanding of DLMS is quite high, and their perception of the availability and quality of available DLMS is at a good level. This research also found that understanding DLMS and perceptions of DLMS as a learning medium can increase students' cognitive achievement in productive subjects.
Applied English Listening Strategy on Vocational High School Students of Accounting Department
Authors: Arisman Rizal
Published: September 2024

This research came with the problem of the type and level of the metacognitive, cognitive, and socio-affective listening strategy used by the eleventh-grade students at SMK Negeri 1 Baubau during the listening comprehension session of the English subject. These strategies were important for developing language skills and understanding in various contexts. They could be consciously taught and practiced to improve listening comprehension and communication skills. This research aimed to determine the type and level of metacognitive, cognitive, and socio-affective listening strategy used by the eleventh-grade students at SMK Negeri 1 Baubau during the listening comprehension session of English subject. This research applied a descriptive method to reveal the findings related to the listening strategies. Sixty-seven eleventh-grade students of SMP Negeri 1 Baubau were involved as the research sample. The result found that the students applied three types of listening strategies: metacognitive, cognitive, and socio-affective strategy, in which the metacognitive and the socio-affective were more highly used than the cognitive strategy. Furthermore, those three types of listening strategies obtained high levels of utilization. Accordingly, it was concluded that the students frequently used all strategies in learning English listening comprehension. Summarily, it was expected that by the high use of listening strategy, they were able to be contained in the instruction activity of listening comprehension to promote the students’ learning comprehension achievement.
Innovations in the Development of Environmental Care Character of Vocational High School in the 21st Century
Authors: Syahriani Fadilla , Ananda Azwar , Montessori Maria , Heldi Heldi , Yufriadi Ferdi
Published: September 2024

This research explores groundbreaking innovations in fostering environmental stewardship within school institutions during the 21st century. In today's world, there is an increasing global emphasis on sustainable living and environmental stewardship, which necessitates the integration of these values into the educational structure, especially at the primary level. By examining various pedagogical strategies, curriculum enhancements, and community engagement initiatives undertaken by educators in Vocational High Schools (SMK), particularly SMK Negeri 1 Ampek Angkek, this study aims to foster a deep sense of environmental responsibility among students. Through a comprehensive review of contemporary practices, this research aims to identify successful models and best practices that contribute to effective environmental character development. The findings from this study not only offer valuable insights for educators and administrators at SMK Negeri 1 Ampek Angkek, but also contribute to a broader discussion on the integration of environmental education into the primary and religious education systems in the 21st century. Ultimately, this exploration serves as a catalyst for advancing environmental literacy and advocacy within educational settings, empowering students to become conscientious stewards capable of addressing the ecological challenges of our time. By nurturing a generation of environmentally conscious individuals, educational institutions can play a pivotal role in fostering a sustainable future for all.
The Effect of the Community - based Mental Health Program on the Improvement of Daily Living Skills for the Chronic Mentally Ill
Authors: Lee Kyoung Soon , Kim Yoon Hee
Published: September 2024

The purpose of this study was to develop an in strument to check daily living skills for chronic mentally ill, to analyze the effectiveness of a community-based mental health program on the im provement of daily living skills for the chronic mentally ill, to find out the difference of their daily living skill levels according to the duration of their participation in the community-based mental health program.The research design was a form of single group pre-post experimental design.The subjects for this study were 26 chronic mentally ill who lived with their family members in the community, and participated in community - based mental health program of Songbuk Health Promoting Center.The data were gathered from August 1, 1996 to August 31，1997, and analyzed using paired t-test and one way ANOVA with SPSS pc.The results of this study were as follows :Main hypothesis : The hypothesis, “there will be a difference in the scores of daily living skills of chronic mentally ill according to the duration of their participation in the community-based mental health program", was supported (the mean at 0 month : 2.66, the mean after 6 months : 2.93, the mean after 12 months : 3.18, F=3.29, p=.0425). Subhypothesis 1 : The subhypothesis, “there will be a difference in the scores of before(0 month) and after (6 months) participating in the communitybased mental health program”，was supported (the mean at 0 month : 2.66, the mean after 6 months :2.93, t=-3.15, p=.004). After the participation in the program, the chronic mentally ill get higher scores of their daily living skills than before the par ticipation in the program.Subhypothesis 2 : The subhypothesis, **there will be a difference in the scores of after 6 months and 12months after the participation in the program”, was supported (the mean after 6 months : 2.93, the mean after 12 months : 3.18, t=-2.41, p=.023).Subhypothesis 3 : The subhypothesis, “there will be a difference in the scores of before(0 month) and after 12 months participation in the program**, was supported (the mean at 0 month : 2.66, the mean after 12 months : 3.18, t=-4.14, p=.000).After the participation in the program, the chronic mentally ill get higer scores of their daily living skills than before the participation the program. The people who partricipated in the community-based mental health program for a longer period, showed the more improvement in their daily living skills.