bluuebunny/crossref_metadata_2025 huggingface dataset:
Further generalization, refinements of the Young inequality
Authors: Ighachane Mohamed Amine , Akkouchi Mohamed
Published: April 2021

In this paper, we show a new generalized refinement of Young's inequality. As applications we give some new generalized refinements of Young type inequalities for the traces, determinants, and norms of positive definite matrices.
The probability of an automorphism of an abelian group fixing a group element
Authors: Arora Harsha
Published: April 2021

In this paper, we consider the probability of an automorphism of a finite abelian group fixing a group element. Explicit computations are made to find the fusion classes of a finite abelian groups. The probability of an automorphism fixing a group element is obtained in terms of fusion classes. We also compute the bounds of the probability for some particular cases.
Affordances and tensions in recording bird observations: how coordinators and volunteers perceive and experience citizen science in birding
Authors: Verploegen Helen , Ganzevoort Wessel , van den Born Riyan
Published: April 2021

Digital citizen science projects differ greatly in their goals and design. Tensions arise when coordinators' design choices and conceptions of citizen science conflict with users' motivations and expectations. In this paper, we use a combination of qualitative methods to gain new insights into the ways citizen science is understood and implemented digitally. This includes a study into the affordances of two citizen science portals for bird observations, and qualitative interviews with users and coordinators of the portals. This reveals tensions related to data sharing, community hierarchies, and communicated expectations. Awareness of these tensions can benefit the future design of online citizen science projects.
Construyendo comunidad desde lo público: el caso de las Superilles Socials
Authors: Moreno-Colom Sara
Published: April 2021

El artículo analiza el papel de lo público en la construcción de lo común con relación a la organización social de los cuidados. Como hipótesis de partida se apunta que las acciones realizadas desde la política pública pueden contribuir a fomentar el papel de la comunidad en la organización social de los cuidados, así como la profesionalización del trabajo de atención a la dependencia. A partir de una estrategia metodológica cualitativa, se presenta el estudio de caso realizado sobre el piloto de un nuevo modelo de gestión del Servicio de Atención Domiciliaria impulsado desde el Ayuntamiento de Barcelona bajo el concepto de las Superilles Socials. Los resultados ponen de manifiesto el potencial técnico de lo público para propiciar lo común, al tiempo que señalan la importancia de factores sociales, como las características del territorio o la creación de identidad, para el éxito de un modelo basado en la cotidianeidad y la autogestión.
Festivales en el territorio y acceso a la cultura. Análisis de los festivales culturales como elemento de desarrollo territorial en la provincia de Castellón
Authors: Querol Vicente Vicent A. , Ginés Sánchez Xavier
Published: April 2021

Este artículo plantea una radiografía sobre el fenómeno de los festivales en un ámbito territorial de fuertes contrastes tanto demográficos como en nivel de desarrollo en la provincia de Castellón. El objetivo es, pues, observar las posibles implicaciones que puede tener la distribución de eventos culturales característicos de la actualidad como son los festivales en las áreas rurales del territorio. Así, nos preguntamos sobre las tendencias en cuanto a festivales culturales en la zona y cuáles son los ámbitos artísticos más programados. Pero también se tratará de observar la naturaleza más comercial o social de los festivales culturales. Con estas y otras variables registradas sobre los festivales, abordaremos la incidencia que pueden tener dichos festivales sobre la sostenibilidad de los territorios más vulnerables.
Las utopías reales de Erik Olin Wright: ¿una reconstrucción científica del socialismo utópico?
Authors: Sola Jorge
Published: April 2021

El conjunto de la obra de Erik O. Wright puede concebirse como un esfuerzo por reconstruir el marxismo en dos direcciones: el análisis de clase y la formulación de alternativas al capitalismo, a las que llamó “utopías reales”. Este artículo se propone ofrecer un balance crítico de este segundo programa de investigación. Para ello, tras presentar el proyecto de las utopías reales y enmarcarlo en la agenda de una “ciencia social emancipadora”, se examinan tanto el marco teórico-conceptual que sirve de base al diseño institucional de estas propuestas utópico-realistas como la defensa de Wright de una estrategia gradualista de erosión del capitalismo. Ambos planos –el institucional y el estratégico– se caracterizan por un pluralismo que busca liberar a la imaginación política de ciertos marcos mentales en los que suele quedar confinada, lo que hace de este intento por reconciliar el espíritu utópico con la investigación científica un programa abierto a desarrollos futuros.
Lourdes Gaitán, Yannis Pechtelidis, Catarina Tomás y Natália Fernandes (eds.). Children’s Lives in Southern Europe. Contemporary Challenges and Risks. Reino Unido y Massachusetts: Edward Elgar Publishing, 2020, 247 páginas
Authors: Lebrusán Irene
Published: April 2021

Los estudios de la infancia, a pesar de destacables avances en los últimos años, es un campo de investigación aún en desarrollo. Los análisis de esta etapa vital cometen, en ocasiones, el error de perder de vista la agencia de los propios actores (niños, niñas y  adolescentes) o de reducir la realidad experimentada desde una compresión adultocéntrica del mundo. Es habitual que los análisis de la infancia se elaboren desde una posición en la que ellos reciben, pero no emiten, olvidando así su papel como actores de su propia vida.
Evaluasi Pelaksanaan Layanan Voluntary Counseling and Testing (VCT) Dalam Program Pencegahan HIV/AIDS di Puskesmas Pakuan Baru Kota Jambi
Authors: Hubaybah Hubaybah , Wisudariani Evy , Lanita Usi
Published: April 2021

Peningkatan kasus HIV/ AIDS ini diduga salah satunya disebabkan oleh ditutupnya kawasan lokalisasi Payo Sigadung. Pasca ditutupnya Payo Sigadung tahun 2014 lalu, tentunya menjadi salah satu “ancaman” dikarenakan sulitnya petugas kesehatan melakukan kontrol dan pengawasan terhadap pekerja seks komersial (PSK) tersebut. Hal ini dikarenakan kuat dugaan para pekerja seks komersial tersebut masih bekerja dengan sembunyi-sembunyi dan bahkan menyebar ke luar Payo Sigadung seperti di kawasan hiburan malam dan tempat-tempat lain seperti warung remang-remang dan tempat-tempat lainnya. Sehubungan dengan itu tentunya diperlukan inisiatif masyarakat yang memiliki kesadaran untuk melakukan pemeriksaan kesehatan secara berkala. Salah satu sarana yang bisa dimanfaatkan oleh masyarakat adalah layanan Voluntary Counseling and Testing (VCT) yang tersedia di Puskesmas. Penelitian ini bertujuan untuk melakukan Evaluasi Pelaksanaan Layanan VCT dalam Program Pencegahan HIV/AIDS di Puskesmas Pakuan Baru Kota Jambi. Studi Kualitatif dengan wawancara mendalam pada Maret-November 2020. Informan dalam penelitian ini yaitu konselor HIV/AIDS, petugas laboratorium/ farmasi, petugas administrasi dan pengunjung layanan VCT.Hasil penelitian yaitu Pelaksanaan layanan VCT, tingkat pengetahuan/ pemahaman informasi, sarana dan prasarana umumnya sudah cukup baik. Perlu adanya evaluasi berkala terhadap pelaksanaan layanan VCT, peningkatan ketrampilan petugas agar dapat menggali informasi lebih dalam dari pasien, perlu adanya peningkatan pengetahuan melalui pelatihan yang rutin.

Kata Kunci: HIV/AIDS, VCT, Puskesmas
HARGA DIRI MANTAN PECANDU NARKOBA YANG BEKERJA DI PUSAT REHABILITASI “X” JAMBI
Authors: Rahmi Tira Nalvianti , Raudhoh Siti , Fitri Amelia Dwi
Published: April 2021

Introduction: Ex-drug addicts might potentially experience a relapse. Previous research had found that one of the factors that could affect ex-drug addicts to survive from a relapse was selfesteem. Self-esteem is essential for every human being, especially for the ones who are in their recovery, such as addiction recovery. This research aimed to describe the self-esteem of ex-drug addicts working at a rehabilitation center.
Method: The participants of this research were three men working at a rehabilitation center and had stopped using drugs minimum in a year. This research was conducted in Jambi in 2018, used a qualitative research method with a phenomenology approach. The data collection technique used an in-depth interview.
Result: All of the participants still disregarded some values yet had some appropriate experiences in other aspects of self-esteem. The main factors that significantly contributed to their self-esteem were relatively different.
Conclusions and recommendation: It appears that the self-esteem of all the participants tendsto lead to the mediumcategory
Keywords: addiction recovery, ex-drug addict, rehabilitation, self-esteem
 
ABSTRAKLatar Belakang: Mantan pecandu narkoba yang berhasil lepas dari ketergantungan narkoba berpotensi untuk mengalami kekambuhan. Penelitian sebelumnya menemukan salah satu faktor yang dapat mempengaruhi mantan pecandu narkoba mampu bertahan untuk tidak kembali menggunakan narkoba adalah harga diri. Harga diri penting dalam kehidupan seseorang, terutama bagi seseorang yang sedang dalam masa pemulihan, seperti pemulihan adiksi. Penelitian ini mendeskripsikan mengenai harga diri pada mantan pecandu narkoba yang bekerja di pusat rehabilitasi “X” Jambi.
Metode: Partisipan penelitian ialah tiga orang laki-laki dewasa yang berusia antara 25-45 tahun, sedang bekerja sebagai staf di pusat rehabilitasi “X” Jambi, dan telah berhenti menggunakan narkoba minimal satu tahun. Penelitian dilakukan di Kota Jambi pada tahun 2018, menggunakan metode penelitian kualitatif dengan pendekatan fenomenologi, serta metode pengumpulan data melalui teknik wawancara mendalam.
Hasil: Ketiga partisipan masih belum memenuhi beberapa nilai-nilai kebajikan, namun partisipan telah berhasil memenuhi sebagian besar nilai yang terkandung dalam aspek harga diri. Faktor yang paling berperan dalam pembentukan harga diri masing-masing partisipan secara khusus memiliki perbedaan yang mendasar.
Kesimpulan dan Saran: Harga diri ketiga partisipan cenderung mengarah ke dalam kategori harga diri sedang berdasarkan keseluruhan aspek yang hampir terpenuhi dan beberapa yang tidak terpenuhi.
Kata kunci: harga diri, mantan pecandu narkoba, pemulihan adiksi, rehabilitasi
Pengaruh pertumbuhan ekonomi, rata-rata lama sekolah dan tingkat pengangguran terhadap tingkat kemiskinan di Provinsi Jambi
Authors: Putri Syabrina Nandita , Hardiani Hardiani , Mustika Candra
Published: April 2021

This study aims to: 1) To analyze the conditions of economic growth, the average length of schooling, unemployment rate, the poverty rate in Jambi Province 2001-2018. 2) To analyze the effects of economic growth, the average length of schooling, and the unemployment rate on poverty levels in Jambi Province in the period 2001-2018. The research analysis tool uses multiple linear regression analysis tools. Based on the results of the simultaneous test that economic growth, the average length of schooling, and unemployment rate together have a significant effect on poverty levels in Jambi Province, while the partial test results say that the significant effect on poverty levels is the variable of economic growth and the average length of the school. Then the results of the determination test indicate that the level of poverty is influenced by the independent variables in this study that is equal to 60.7 percent.

Keywords: Economic growth, Average length of school, Unemployment rate, Poverty rate
Analisis sub sektor perkebunan Provinsi Jambi
Authors: Fitriandi Popi , Hardiani Hardiani , Mustika Candra
Published: April 2021

The purpose of this research is first, to know and analyze the development of the land area, labor, and GRDP of the plantation sub-sector in Jambi Province. Second, knowing and analyzing the contribution of the plantation sub-sector to the agricultural sector and the GRDP of Jambi Province. Third, to analyze the effect of land area and labor on the output of the plantation sub-sector in Jambi Province. The development of the land area, labor, GDP in the plantation sub-sector of Jambi Province for the period 2000-2015 continued to increase, with an average increase in land area of ​​2.52%, a workforce of 2.74%, GRDP of the plantation sub-sector by 7.84%. The contribution of the plantation sub-sector to the agricultural sector and the GRDP of Jambi Province for the period 2000-2015 also continued to increase. Based on the results of multiple linear regression calculations, simultaneously land area and labor have a significant effect on the output of the plantation sub-sector in Jambi Province. Partially, land area has a significant effect on the output of the plantation sub-sector in Jambi Province, while labor does not affect the output of the plantation sub-sector in Jambi Province.
Keywords: Land area, Labor, Gross regional domestic product of plantation sub sector
Analisis pergeseran sektor unggulan Kabupaten Tanjung Jabung Barat
Authors: Munthe Alex Salenko , Zulgani Zulgani , Hardiani Hardiani
Published: April 2021

The purpose of this research is to analyze the shifts that occur to the three leading sectors in the Regency of West Tanjung Jabung and to find out how much contribution from the three leading sectors to the economic growth during the period 2011-2015. The data collection method used in this research is secondary data analysis which is collecting data through the material of the library. From based on the result of data analysis, the result of the shift of the three leading sectors of the economy Tanjung Jabung District West during 2011-2015 using shift-share analysis changed at the national level (Ns) of 3,851,361.79, with a differential shift (D) value of -34,748.82 and proportional shift (P) value of -295,710.45, where the value of shifting the three leading sectors experienced development in the period 2011-2015 amounted to 3,520,902.92. The three leading sectors are classified into the analysis of Typology Klassen to determine the value of its contribution to the growth rate of the region, where the mining and quarrying sectors become the first quadrant, the manufacturing sector becomes the second quadrant, and then the agriculture, forestry, and fishery sectors become the third quadrant.
Keywords: Leading sector, Shift-share, Typology klassen, Economic growth.
Analisis pengaruh pertumbuhan ekonomi, pengeluaran pemerintah, upah minimum dan tingkat pendidikan terhadap tingkat pengangguran terbuka Provinsi-Provinsi di Sumatera
Authors: Syahputra Angga , Erfit Erfit , Nurhayani Nurhayani
Published: April 2021

This study aims to: 1) To analyze the development of the open unemployment rate, economic growth, government spending, minimum wages, and the level of education of the provinces in Sumatra. 2) To find out and analyze what factors influence the income of street vendors on Jalan Basuki Rahmat to General H. Agus Salim by using panel data regression analysis tools. The development of the level of open unemployment, economic growth, and government spending in the provinces on the island of Sumatra during 2015-2017 fluctuated, however, the minimum wage and education level tended to increase. The regression results show that part, the variables of economic growth and the level of education have a significant effect on the level of open unemployment, while the variables of government spending and the minimum wage have no significant effect on the level of open unemployment in the provinces of Sumatra Island.
Keywords: Open unemployment rate, Economic growth, Government expenditures, Minimum wages, Education level
Analisis pengaruh pertumbuhan ekonomi dan pengangguran terbuka terhadap jumlah penduduk miskin di Kabupaten Tebo
Authors: Zurlinda Zurlinda , Hari Prihanto Purwaka , Kusuma Edy Jaya
Published: April 2021

The purpose of this study was to determine and analyze: (1) the development of economic growth, open unemployment, and the number of poor people in Tebo Regency 2002-2015. (2) the development of poverty depth index and poverty severity index in Tebo Regency 2002-2015 period. (3) the effect of economic growth and open unemployment on the number of poor people in Tebo District 2002-2015. The method used in this research is the descriptive analysis method. The results of this study are economic growth and open unemployment in Tebo Regency for the period 2002-2015, which increased respectively by an average of 5.89% and 25.45% per year, then for the number of poor people in Tebo Regency in the 2002 period -2015 decreased by 1.36 percent. The results of this study also indicate a negative influence from the variables of economic growth and open unemployment on the number of poor people in Tebo Regency.

Keywords : Economic growth, Open unemployment, The number of poor people
Analisis sektor unggulan di Kabupaten Batanghari
Authors: Syaputra Andi , Hardiani Hardiani , Bhakti Adi
Published: April 2021

This study aims to analyze the leading sectors in the economy in Batanghari Regency. This study uses secondary data for the period 2011-2017, sourced from the Central Statistics Agency of Jambi Province and Batanghari Regency. The analysis tools used are Location Quotient (LQ) analysis and Shift Share analysis. The results of the study found that the leading sectors in Batanghari Regency are the manufacturing industry sector, the government administration sector, defense, compulsory social security, and the education service sector.
Keywords: Leading sector, Location quotient, Shift share
A beginner's guide to low-coverage whole genome sequencing for population genomics
Authors: Lou Runyang Nicolas , Jacobs Arne , Wilder Aryn , Therkildsen Nina Overgaard
Published: April 2021

Low-coverage whole genome sequencing (lcWGS) has emerged as a powerful
and cost-effective approach for population genomic studies in both model
and non-model species. However, with read depths too low to confidently
call individual genotypes, lcWGS requires specialized analysis tools
that explicitly account for genotype uncertainty. A growing number of
such tools have become available, but it can be difficult to get an
overview of what types of analyses can be performed reliably with lcWGS
data, and how the distribution of sequencing effort between the number
of samples analyzed and per-sample sequencing depths affects inference
accuracy. In this introductory guide to lcWGS, we first illustrate how
the per-sample cost for lcWGS is now comparable to RAD-seq and Pool-seq
in many systems. We then provide an overview of software packages that
explicitly account for genotype uncertainty in different types of
population genomic inference. Next, we use both simulated and empirical
data to assess the accuracy of allele frequency and genetic diversity
estimation, detection of population structure, and selection scans under
different sequencing strategies. Our results show that spreading a given
amount of sequencing effort across more samples with lower depth per
sample consistently improves the accuracy of most types of inference,
with a few notable exceptions. Finally, we assess the potential for
using imputation to bolster inference from lcWGS data in non-model
species, and discuss current limitations and future perspectives for
lcWGS-based population genomics research. With this overview, we hope to
make lcWGS more approachable and stimulate its broader adoption.
Association of maternal obesity with preterm birth phenotype and mediation effects of gestational diabetes mellitus and preeclampsia：a prospective cohort study
Authors: liu kan , chen yixuan , wu xiaoxia , tian fuying , tong jianing , yin aiqi , guan xiaonian , wu linlin , niu jianmin
Published: April 2021

Objectives: To clarify the relationship between prepregnancy body mass
index (BMI) and the phenotypes of preterm birth and evaluate the
mediation effects of gestational diabetes mellitus (GDM) and
preeclampsia (PE) on the relationship between prepregnancy BMI and
preterm birth. Design: Prospective cohort study Setting: Shenzhen
Maternity & Child Healthcare Hospital Population or Sample: 42196
singleton livebirths Methods: Prospective cohort study using the Birth
Cohort in Shenzhen (BiCoS) dataset. Main Outcome Measures: Preterm birth
was defined as gestational age less than 37 weeks. Results: Risks of
extremely, very, and moderately preterm birth increased with BMI, and
the highest risk was observed for obese women with extremely preterm
birth (OR 3.43, 95% CI 1.07 –10.97). Maternal obesity was
significantly associated with spontaneous preterm labor (OR 1.98; 95%
CI 1.13–3.47), premature rupture of the membranes (OR 2.04; 95% CI
1.08–3.86) and medically indicated preterm birth (OR 2.05; 95% CI
1.25–3.37). GDM and PE mediated 13.41% and 36.66% of the effect of
obesity on preterm birth, respectively. GDM mediated 32.80% of the
effect of obesity on spontaneous preterm labor and PE mediated 64.31%
of the effect of obesity on medically indicated preterm birth.
Conclusions: Maternal prepregnancy obesity was associated with all
phenotypes of preterm birth, and the highest risks were extremely
preterm birth and medically indicated preterm birth. GDM and PE
partially mediated the association between obesity and preterm birth.
Funding: NSFC(81830041, 81771611); Shenzhen Science and Technology
Project (JCYJ20170412140326739) KEYWORDS: obesity, prepregnancy BMI,
preterm birth, phenotype, gestational diabetes mellitus, preeclampsia
Vascular Expression of Permeability-Resistant Occludin Mutant Preserves Visual Function in Diabetes
Authors: Goncalves Andreia , Dreffs Alyssa , Lin Cheng-mao , Sheskey Sarah , Hudson Natalie , Keil Jason , Campbell Matthew , Antonetti David A.
Published: April 2021

Diabetic retinopathy is one of the leading causes of vision loss and blindness. Extensive preclinical and clinical evidence exists for both vascular and neuronal pathology. However, the relationship of these changes in the neurovascular unit and impact on vision remains to be determined. Here, we investigate the role of tight junction protein occludin phosphorylation at S490 in modulating barrier properties and its impact on visual function. Conditional vascular expression of the phosphorylation-resistant Ser490 to Ala (S490A) form of occludin preserved tight junction organization and reduced vascular endothelial growth factor (VEGF)-induced permeability and edema formation after intraocular injection. In the retinas of streptozotocin-induced diabetic mice, endothelial-specific expression of the S490A form of occludin completely prevented diabetes-induced permeability to labeled dextran and inhibited leukostasis. Importantly, vascular-specific expression of the occludin mutant completely blocked the diabetes-induced decrease in visual acuity and contrast sensitivity. Together, these results reveal that occludin acts to regulate barrier properties downstream of VEGF in a phosphorylation-dependent manner and that loss of inner blood-retinal barrier integrity induced by diabetes contributes to vision loss.
Dasiglucagon—A Next-Generation Glucagon Analog for Rapid and Effective Treatment of Severe Hypoglycemia: Results of Phase 3 Randomized Double-Blind Clinical Trial
Authors: Pieber Thomas R. , Aronson Ronnie , Hövelmann Ulrike , Willard Julie , Plum-Mörschel Leona , Knudsen Kim M. , Bandak Benedikte , Tehranchi Ramin
Published: April 2021

OBJECTIVE

To evaluate the efficacy and safety of dasiglucagon, a ready-to-use, next-generation glucagon analog in aqueous formulation for subcutaneous dosing, for treatment of severe hypoglycemia in adults with type 1 diabetes.

RESEARCH DESIGN AND METHODS

This randomized, double-blind trial included 170 adult participants with type 1 diabetes, each randomly assigned to receive a single subcutaneous dose of 0.6 mg dasiglucagon, placebo, or 1 mg reconstituted glucagon (2:1:1 randomization) during controlled insulin-induced hypoglycemia. The primary end point was time to plasma glucose recovery, defined as an increase of ≥20 mg/dL from baseline without rescue intravenous glucose. The primary comparison was dasiglucagon versus placebo; reconstituted lyophilized glucagon was included as reference.

RESULTS

Median (95% CI) time to recovery was 10 (10, 10) minutes for dasiglucagon compared with 40 (30, 40) minutes for placebo (P < 0.001); the corresponding result for reconstituted glucagon was 12 (10, 12) minutes. In the dasiglucagon group, plasma glucose recovery was achieved within 15 min in all but one participant (99%), superior to placebo (2%; P < 0.001) and similar to glucagon (95%). Similar outcomes were observed for the other investigated time points at 10, 20, and 30 min after dosing. The most frequent adverse effects were nausea and vomiting, as expected with glucagon treatment.

CONCLUSIONS

Dasiglucagon provided rapid and effective reversal of hypoglycemia in adults with type 1 diabetes, with safety and tolerability similar to those reported for reconstituted glucagon injection. The ready-to-use, aqueous formulation of dasiglucagon offers the potential to provide rapid and reliable treatment of severe hypoglycemia.
Evaluation of the Viability of Probiotic Microorganisms in Microcapsules with Passion Fruit Pulp Resulting From the Ionic Gelation Process
Authors: R Xavier Anne Caroline
Published: April 2021

One of the limiting factors of food probiotic microorganism’s addition consists in its viability. Several microencapsulation techniques were explored, the external ionic gelation proved to be viable in the preservation of probiotic cultures. The objective of this study was to evaluate the effect of the ionic gelation process of passion fruit pulp with probiotics, in order to verify the storage time of these products when submerged in their own pulp and packaged in glass containers submitted to storage refrigerated. The product submitted shelf life of 60 days and the microorganism showed feasibility during the entire period of storage studied. It is then emphasized the viability of the ionic gelification of the passion fruit pulp, as the microcapsules obtained in this process present nutritional characteristics similar to the passion fruit pulp.
TRICOPTEROFAUNA DEL RÍO PALMAR, CUNDINAMARCA, COLOMBIA
Authors: González-Vargas Geraldine , García-García Alexander
Published: April 2021

La variación comportamental de la diversidad en diferentes escalas altitudinales es una de las variables que menos se han trabajado en insectos acuáticos, por lo cual, el objetivo de esta investigación fue establecer cómo varía la composición del orden Trichoptera presente en el río Palmar, Cundinamarca, Colombia con respecto al gradiente altitudinal y determinar las condiciones fisicoquímicas particulares que se distribuyen desde su nacimiento hasta su desembocadura, durante los meses de septiembre 2018 a febrero 2019, la captura de los individuos se llevó a cabo empleando una red Surber y una red tipo D, los parámetros fisicoquímicos se midieron in situ. Se recolectaron 3.838 especímenes pertenecientes a 10 familias y 18 géneros, de los cuales se hace el primer registro de los géneros Anchitrichia (Flint, 1970), Cerasmatrichia (Flint et al., 1994) y Neotrichia (Morton, 1905) de la familia Hydroptilidae para Cundinamarca. La tricopterofauna en las zonas evaluadas mostró una variación a nivel espacial, exhibiendo la mayor riqueza y abundancia en la zona de Ubaque. Los géneros Atopsyche (Banks, 1905), Helicopsyche (Siebold, 1856) y Smicridea (McLachlan, 1871) presentaron los mayores rangos de distribución al encontrase presente en todas las zonas. El análisis de correspondencia canónica realizado evidenció que el pH y la temperatura son las variables que tienen mayor peso en la distribución de las larvas.
EVALUACIÓN DEL RIESGO AMBIENTAL DE LA MEZCLA DE ALFA-CIPERMETRINA E IMIDACLOPRID SOBRE LA LOMBRIZ DE TIERRA (EISENIA FETIDA) (SAVIGNY, 1826)
Authors: Arrázola-Vásquez Elsa María , Iannacone José
Published: April 2021

En el presente estudio, se evaluó el riesgo ambiental (ERA) de la alfa-cipermetrina y del imidacloprid, individualmente y en mezcla, sobre Eisenia fetida (Savigny, 1826). La concentración letal media (CL50) para la alfa-cipermetrina y el imidacloprid fue de 341,1 mg·kg-1 y 2,34 mg·kg-1 a los 14 d de exposición, respectivamente, siendo más tóxico el imidacloprid. Se observó una reducción en el peso seco y húmedo en E. fetida, para ambos plaguicidas. La mezcla de alfa-cipermetrina e imidacloprid no permitió calcular la CL50 para la mortalidad; sin embargo, los valores subletales de NOEC (concentración a la cual no se observa efecto) y LOEC (concentración más baja a la cual se observa efecto), para el peso húmedo y seco de E. fetida, presentaron diferencias significativas con el control. Las unidades tóxicas (UT) mostraron un comportamiento antagónico entre la alfa-cipermetrina y el imidacloprid. La prueba de evasión arrojó un mayor efecto de la mezcla de alfa-cipermetrina e imidacloprid, lo que no ocurrió con los ensayos con los plaguicidas individuales. En general, el alfa-cipermetrina y el imidacloprid son considerados compuestos altamente tóxicos y no representaron un riesgo significativo a nivel agudo en base a la mortalidad de E. fetida, pero se observaron efectos subletales por afectación del crecimiento.
Atypical presentation of bartonellosis with hepatolienal lesions
Authors: Lunyakova M. A. , Demikhov V. G. , Inyakova N. V. , Panina E. A.
Published: April 2021

Cat scratch disease is caused by the gram-negative intracellular bacterium Bartonella henselae (B. henselae). Human infection occurs mainly through cat scratches and bites. In typical cases, the clinical course is presented by a primary affect on the skin and regional lymphadenitis. The atypical presentation of infection can occur with fever, abdominal, ocular and neurological manifestations. A special feature of the abdominal form is the presence of solitary or multiple hypo/anechoic foci of different size and shape in the liver and spleen. B. henselae infection is one of the most common mimics of malignant lymphoma, when the spleen is involved in combination with B symptoms (weight loss, night sweats and prolonged fever). A history of recent contact with cats and diagnostic IgG titers to B. henselae indicate infection. There is no consensus on the choice of antimicrobial drug and the duration of therapy for systemic forms. The article presents its own experience in the diagnosis and treatment of such patients. The patient's parents agreed to use the information, including the child's photo, in scientific research and publications.
A rare case of nodular lymphocyte predominant Hodgkin lymphoma, which developed 5 years after successful treatment of diffuse large B-cell lymphoma
Authors: Senchenko M. A. , Abramov D. S. , Rudneva A. E. , Volchkov E. V. , Nasirdinova G. A. , Gobadze D. A. , Myakova N. V. , Konovalov D. M.
Published: April 2021

Nodular lymphocyte predominant Hodgkin lymphoma (NLHLP) – B-cell lymphoma, which has been historically added to the group of Hodgkin's lymphomas, despite the peculiarities of the clinical course, treatment and prognosis, as well as morphological and immunophenotypical differences. In 75% of cases, the disease is detected at early stages (I–II according to Ann Arbor classification), has an indolent course and a favorable prognosis with 10-years an overall survival rate, more than 80%. Despite this, with long-term follow-up and the development of frequent relapses, transformation into diffuse large-cell B-cell lymphoma (DCBCL) or T-lymphocyte/histiocyte-rich DCBCL can occur, isolated cases in children. In the world literature, there are isolated cases of the development of NLHLP after treatment of DCBKL in adults, while among the pediatric population, cases have not been described. This article presents a clinical case of DCBKL in a 10-year-old child who, 5 years after the end of treatment, developed nodular Hodgkin's lymphoma with lymphocytic predominance. The patient's parents agreed to use the information, including the child's photo, in scientific research and publications.
Causes of transfer and mortality in children with oncohematological diseases admitted to the intensive care unit
Authors: Aliyeva F. S. , Muldahmetov M. S. , Nurmagambetova B. K.
Published: April 2021

The last few decades survival rates of children with hematologic malignancies have improved significantly, due to a potentially curative chemotherapy protocols, the expansion of biological knowledge and innovative methods of therapy. However oncohematological pediatric patients are at high risk for rapid clinical deterioration due to numerous factors such as the severity of the underlying condition, interventions toxicity and associated immunosuppression. Using aggressive tactics of therapy with oncohematological diseases in children is also associated with complications and life-threatening events that lead to admission to the pediatric intensive care unit. Historically, these children have been considered as poor candidates for intensive care. Discussions around the transfer of children with hematological malignancies to intensive care units and also the expected prognosis raised complicate and delicate questions, especially from an ethical point of view. Despite the general tendency of improved survival rate, mortality in the intensive care unit on hematological malignancies children, unfortunately, is still high and, in comparison to adults, has remained relatively invariable over the past decades. These findings highlight the necessity for research in this group of patients.
Platelets in COVID-19: “innocent by-standers” or active participants?
Authors: An O. I. , Martyanov A. A. , Stepanyan M. G. , Boldova A. E. , Rumyantsev S. A. , Panteleev M. A. , Ataullakhanov F. I. , Rumyantsev A. G. , Sveshnikova A. N.
Published: April 2021

One of the most dangerous features of the new coronavirus infection caused by the SARS-CoV-2 virus is the tendency of the hemostasis system of patients to excessive thrombus formation. Among the possible causes of this pathology, both the activation of vascular endothelial cells, leading to the exposure of tissue factor by these cells, and direct activation of the plasma hemostasis were named. Besides, there is a significant change in platelet responses to activation, which is not accompanied by significant thrombocytopenia. The mechanism of platelet dysfunction is rather controversial. On the one hand, there are suggestions that platelets can act as a direct “container” for the virus, thus spreading it throughout the body. On the other hand, the presence of viral RNA in platelets has been demonstrated in only one study, while other authors have obtained the opposite result. Another mechanism of the virus's direct effect on platelets is the penetration of the virus into megakaryocytes and the subsequent violation of thrombocytopoiesis. However, three of the four published works show that platelets from patients with SARS-CoV-2 are in an activated state (the so-called platelet pre-activation). This phenomenon can be caused by the direct influence of the virus and the effect of thromboinflammation in the lungs on platelet functions. Here we review the known data and possible causes of the platelet functionality changes observed in patients with SARS-CoV-2.
Analysis of platelet RNA: a non-invasive method for studying the expression of tumor genes
Authors: Tesakov I. P. , Martyanov A. A. , Drui A. E. , Sveshnikova A. N.
Published: April 2021

Nowadays much attention is paid to non-invasive methods of cancer diagnostics and monitoring. One of the promising methods is the sequencing of platelet RNA (tumor-educated platelets), in which, as it was previously established, the mRNA repertoire changes in various oncological diseases. Thus, platelets can contain information about the molecular genetic characteristics of tumor. This review summarizes the current understanding of the mechanisms of interaction between tumor cells and platelets, and also discusses the possibilities of using platelet transcriptome analysis methods for diagnosing and assessing the dynamics of the tumor state, in particular, in response to therapy, as well as the current limitations for a wide range of introduction of this method into clinical practice.
Assisted reproductive technologies and children's health parameters
Authors: Samoilova Yu. G. , Matveeva M. V. , Petrov I. A. , Kudlay D. A. , Davydova M. S. , Ratkina K. R. , Mitselya E. V. , Sivolobova T. V. , Gaifulina Zh. F.
Published: April 2021

The review presents a description of the health status of children conceived using assisted reproductive technologies, identifies possible causes and risk factors for the development of pathology.
Immunophenotypic characterization of pediatric acute myeloid leukemia with inv(16)(p13.1q22)/t(16;16)(p13.1;q22)/CBFb-MYH11
Authors: Mikhailova E. V. , Kashpor S. A. , Zerkalenkova E. A. , Semchenkova A. A. , Dubrovina M. E. , Plyasunova S. A. , Olshanskaya Yu. V. , Kalinina I. I. , Maschan M. A. , Maschan A. A. , Novichkova G. A. , Popov A. M.
Published: April 2021

The aim of this study was to describe the immunophenotype of leukemic cells in acute myeloid leukemia (AML) with inv(16) (p13.1q22)/CBFb-MYH11 and t(16;16)(p13.1;q22)/CBFb-MYH11 in children. This study is supported by the Independent Ethics Committee and approved by the Academic Council of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology. We investigated bone marrow samples from 36 pediatric patients with initially diagnosed AML with inv(16)(p13.1q22)/t(16;16)(p13.1;q22)/CBFb-MYH11. Immunophenotypic profile of leukemic cells was very heterogeneous: cells expressed antigens of early stages of differentiation (CD34, CD117, CD123) as well as markers of mature monocytes (CD11c, CD14, CD64) and neutrophils (CD65, CD15). Moreover, in 55.6% of cases lymphoid coexpressions were noticed (CD2 – the most frequent one). Furthermore, in 83.3% of cases we detected the separation of leukemic cells population into two parts: more “immature” – myeloblastic, which expressed early markers of differentiation (CD34, CD117), and more “mature” part, expressing monocytic antigens (CD11b, CD14, CD33). There was no clear separation between these parts of population. Despite the immunophenotypic similarity between monocytic part of leukemic population and normal monocytes, in 87.5% of studied cases there were same lymphoid coexpressions on these cells as on leukemic myeloblasts. Moreover, we showed that levels of CBFb-MYH11 expression in leukemic monocytes and myeloblasts were comparable. Presence of these characteristics in monocytes allows to consider them as part of leukemic cells population and take into consideration during the total immunophenotype reporting.
Specifities of the storage pool and morphology of platelets in children with unspecified hemorrhagic syndrome
Authors: Polokhov D. M. , Pshonkin A. V. , Ignatova A. A. , Ponomarenko E. A. , Fedorova D. V. , Aleksenko M. Yu. , Voronin K. A. , Seregina E. A. , Poletaev A. V. , Novichkova G. A. , Panteleev M. A. , Zharkov P. A.
Published: April 2021

Despite modern possibilities of laboratory diagnosis of hemorrhagic syndrome, in some patients, the causes of bleeding remain unspecified. Among these reasons, mild defects in the platelet link of hemostasis can potentially be hidden. The aim of the work is to identify the features of the function of the platelet hemostasis in children with unspecified hemorrhagic syndrome. This study is supported by the Independent Ethics Committee and approved by the Academic Council of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology. We examined 50 patients aged 2 to 17 years with various manifestations of bleeding and lack of laboratory data proving coagulopathy and/or thrombocytopenia; platelet cytofluorometry with activation was performed. The morphological characteristics of platelets in terms of size/granularity (FSC/SSC), the density of the CD62p receptor as a marker of a-granule secretion, and d-granules of platelets were assessed by the fluorescence of loaded mepacrine. Platelet activation was performed with a CRP + TRAP mixture. Comparison was carried out with the results of examination of 50 healthy children (control group - CG) aged 2 to 17 years. The severity of hemorrhagic syndrome was assessed using the standardized ISTH BAT score. The severity of hemorrhagic manifestations according to BAT ISTH score ranged from 2 to 6 points. As a result of the study, two groups of patients differing in the calculated parameter of the FSC/SSC ratio for non-activated platelets were identified. In the CG, the median FSC/SSC was 1.235 (from 1.1 to 1.4), in group 1 (n = 19), the median was 0.97 (from 0.9 to 1.05), and in group 2 (n = 31), the median was 1.24 (from 1.11 to 1.43). The number of platelets of the CG and the groups of patients did not differ significantly. A significant correlation between a decrease in the number of platelets and an increase in their size and granularity, while maintaining a high correlation between size and granularity was observed in groups of patients. In group 1, the overall granularity was increased regardless of the size and number of platelets, the volume of dense granules and membrane CD62p was increased, but the granular CD62p was decreased. The degranulation mechanism was not impaired in both groups of patients. Our results indicate convincingly the contribution of the storage pool and platelet morphology disorders to the development of hemorrhagic manifestations in children with unspecified hemorrhagic syndrome.
The Association Between Serum Carnitine Level, Glucose Regulation, Body Fat and Nutrient Intake in Diabetic Individuals
Authors: Özer Şehriban Duyar , Karadağ Makbule Gezmen
Published: April 2021

Carnitine (β-hydroxy-γ-trimethyl amino butyrate) is, a vitamin-like substance carrying long-chain fatty acids into the mitochondrial matrix. Due to its effect in energy metabolism, carnitine plays an important role in controlling diabetes and its complications. Studies on this topic have often focused on carnitine supplementation. This study was planned to investigate the relationship between serum carnitine level, glucose regulation and body fat in diabetic patients. A total of 64 people between the ages of 30-5, 32 patients with type 2 diabetes and 32 healthy subjects, were included in the study. Individual lipid profiles, glucose, insulin and serum carnitine levels were analyzed, anthropometric measurements were taken and 24-hour recall food consumption was recorded. As a result, blood glucose, insulin, triglyceride, VLDL-C, HDL-C and HOMA-IR were found to be higher in diabetic individuals than healthy group (p<0,05). Serum carnitine levels were found to be significantly lower in diabetic male (50,6±20,83 nmol/mL) than in healthy male (59,5±17,25 nmol/mL)(p<0,05). This difference was not statistically significant among female (p>0,05). It has been observed that intake of energy and macronutrients of diabetic individuals is generally lower than that of healthy individuals. Serum carnitine level was positively associated with polyunsaturated fatty acids and omega-6 fatty acid intake in male in the healthy group showed a negative correlation with fiber intake in female in the healthy group (p<0,05). There were negative correlations between serum carnitine level with body weight, body mass index and body fat mass in female in the healthy group (p<0,05). Individuals with diabetes are predisposed to dyslipidemia and insulin resistance. As a result; food consumption, and body fat affect individuals’ serum carnitine levels in type-2 diabetes. Since there is not enough study evaluating the relationship between anthropometric measurements of individuals and serum carnitine levels, it is thought that this result will guide future studies.
Acting Out: Exploring Applied Theatre Practices in Canadian Correctional Facilities
Authors: Omstead Jacqueline
Published: April 2021

The colonization of Aboriginal peoples in North America involved systematic efforts to control and eradicate Indigenous knowledges and cultures. However, Aboriginal peoples have resisted colonization through creative expression; creating space for the exploration and critique of the myriad identities informed by this relationship. This study focuses on work by prominent American and Canadian authors Louise Erdrich, Tomson Highway, and Daniel David Moses. Erdrich, who self-identifies as Chippewa with mixed European ancestry, is best known for the interconnections of short narratives between and within her novels. Tomson Highway, a Cree novelist and playwright, is most famous for his cycles of “rez” plays detailing life on a fictional Ontario reserve. Daniel David Moses, member of the Delaware First Nation in Brantford, Ontario and acclaimed Canadian playwright, is best known for his parody of non-Aboriginal constructions of the “authentic Indian” in his work. These authors use political destruction of normative categories, particularly gender transgression, but also past and present, here and there, material reality and the spirit realm to create space for the playful exploration of Indigenous identities. I explore the ways in which gender transgression is nested in larger themes of playful category destruction and creative reconstruction to open up issues of political importance to these authors. By exploring these themes in conjunction with author biographies and interviews, I identify the political motives and implications of category transgression.
A Distributed Computer System for Parallel Markov Chain Monte Carlo (MCMC)
Authors: Hynes Michael
Published: April 2021

A ubiquitous problem in physics is to determine expectation values of observables associated with a system. This problem is typically formulated as an integration of some likelihood over a multidimensional parameter space. In Bayesian analysis, numerical Markov Chain Monte Carlo (MCMC) algorithms are employed to solve such integrals using a fixed number of samples in the Markov Chain. In general, MCMC algorithms are computationally expensive for large datasets and have difficulties sampling from multimodal parameter spaces. An MCMC implementation that is robust and inexpensive for researchers is desired. Distributed computing systems have shown the potential to act as virtual supercomputers, such as in the SETI@home project in which millions of private computers participate. We propose that a clustered peer-to-peer (P2P) computer network serves as an ideal structure to run Markovian state exchange algorithms such as Parallel Tempering (PT). PT overcomes the difficulty in sampling from multimodal distributions by running multiple chains in parallel with different target distributions andexchanging their states in a Markovian manner. To demonstrate the feasibility of peer-to-peer Parallel Tempering (P2P PT), a simple two-dimensional dataset consisting of two Gaussian signals separated by a region of low probability was used in a Bayesian parameter fitting algorithm. A small connected peer-to-peer network was constructed using separate processes on a linux kernel, and P2P PT was applied to the dataset. These sampling results were compared with those obtained from sampling the parameter space with a single chain. It was found that the single chain was unable to sample both modes effectively, while the P2P PT method explored the target distribution well, visiting both modes approximately equally. Future work will involve scaling to many dimensions and large networks, and convergence conditions with highly heterogeneous computing capabilities of members within the network.