Adjuvant Systemic Therapies in Patients with Colorectal Cancer: An Audit on Clinical Practice in Italy
Authors:   Drug Utilization Review Team in Oncology (DURTO), Roila Fausto , Ruggeri Benedetta , Ballatori Enzo , Patoia Lucio , Palazzo Salvatore , Colucci Giuseppe , Di Costanzo Francesco , Cascinu Stefano , Labianca Roberto , Sobrero Alberto , Cortesi E. , Bressi C. , Ferraldeschi R. , Mazzoli M. , Evangelista M.L. , Di Fonzo C. , Cigolari S. , Angelini V. , Cioffi A. , Guardasole V. , Zarra E. , Tonato M. , Betti M. , Marrocolo F. , Bon-ciarelli V. , Cetto G. , Silingardi V. , Cognetti F. , Beretta G. , Pessi A. , Mosconi S. , Milesi L. , Bertetto O. , Malacarne P. , Marzola M. , Margutti G. , Modenesi C. , Manente P. , Comandone A. , Oliva C. , Berniolo P. , Cutin S. Chiadò , Luporini G. , Colucci G. , Recaldin E. , Nicodemo M. , Picece V. , Turaz-za M. , Ferrazzi E. , Solina G. , Rosati G. , Rossi A. , Manzione L. , Sozzi P. , Fornarini G. , Lavarello A. , Catalano G. , Giordani P. , Alessandroni P. , Troccoli G. , Ramus G. Vietti , Tonda L. , Sirgiovanni M.P. , Iannello G. P. , Tinessa V. , Ruggiero A , Palazzo S. , Barni S. , Mandalà M. , Cremonesi M. , Porcile G. , Destefanis M. , Testore F. , Carteni G. , Daniele B. , Volta C. , Ferraù F. , Zaniboni A. , Marchetti P. , Citone G. , Cefaro G. Ausili , Iacono C. , Musi M. , Mozzicafreddo A. , Imperiale F. Nigro , Filippelli G. , Sciacca V. , D'Aprile M. , Isa L. , Recchia F. , Spada S. , Cascinu S. , Carroccio R. , Mustacchi G. , Ceccherini R. , Chetrì M. , Rizzo P. , Botturi M. , Marchei P. , Bretti S. , Montalbetti L. , Reguzzoni G. , Massidda B. , Ionta M.T. , Cruciani G. , Prosperi A. , Mantovani G. , Sidoti V. , Peta A. , Greco E. , Cicero G. , Sobrero A. , Marsilio P. , Vigevani E. , Rimondi G. , Gebbia V. , Nuzzo A. , Biondi E. , Caroti C. , D'Amico M. , Tuveri G. , Pieri G. , Enrici R. Maurizi , Tonini G. , Santini D. , Iannone T. , Pizza C. , Belli M. , Del Prete S. , Pizza C. , Trevisonne R. , Serlenga M. , Laricchiuta R. , Lacava V. , Bumma C. , Roselli M. , Verderame F. , Mascia V. , Perrone D. , Prantera T. , Venuta S. , Nastasi G. , Bortolussi V. , Lembo A. 
Published: July 2019

Aims and Background

Rarely are conclusions from clinical trials summarized in international consensus conferences and promptly transferred to patient care. The adjuvant therapy for colorectal cancer used in daily clinical practice in Italy is described and compared with the recommendations of the 1990 NIH Consensus Conference.

Patients and Methods

We audited prescriptions of adjuvant systemic therapies for Italian colorectal cancer patients in 82 centers during a fixed one-week period.

Results

Among 434 patients receiving adjuvant chemotherapy there were 139 (42.5%) colon cancer patients with N- and 169 (51.7%) with N+ regional nodal involvement. Treatment at academic centers, a young age, T4 and a low total number of lymph nodes removed at surgery were the factors potentially justifying the decision for adjuvant chemotherapy in stage II colon cancer patients. The most common chemotherapy used was a bolus of 5-fluorouracil/folinic acid for 6 months (75.8%). Adjuvant radiotherapy was not administered to 37 (38.5%) of 96 patients with stage II and III rectal cancer.

Conclusions

The study shows that a substantial proportion of patients on adjuvant treatment at a certain time point in a large enough sample of Italian centers are stage II (potential over-treatment) and that an under-treatment of stage II and III rectal cancer patients (lack of radiotherapy) occurs too often in daily clinical practice in this country.