bluuebunny/crossref_metadata_2025 huggingface dataset:
Detachment of strong shocks in confined granular flows
Authors: Khan Aqib , Hankare Priyanka , Verma Shivam , Jaiswal Yash , Kumar Rakesh , Kumar Sanjay
Published: January 2022

Granular flows are highly dissipative due to frictional resistance and inelasticity in collisions among grains. They are known to exhibit shock waves at velocities that are easily achieved in industrial and nature-driven flows such as avalanches and landslides. This experimental work investigates the formation of strong shock waves on triangular obstacles placed in a dry rapid granular stream in a confined two-dimensional set-up. Oblique attached shock waves are formed for mild turning angles and higher flow velocities, whereas strong bow shock waves are formed for higher turning angles and slower granular streams. A shadowgraph imaging technique elucidates interesting characteristics of the shock waves, especially in the vicinity of shock detachment. Velocity distributions in the form of scatter plots and probability distribution functions are calculated from the flow field data obtained by particle imaging velocimetry. The flow field around the granular shock wave region represents a bimodal distribution of velocities with two distinct peaks, one representing the supersonic flow within the free stream, and the other corresponding to the subsonic faction downstream of a shock wave. Connecting the two is a population that does not directly belong to either of the modes, constituting the non-equilibrium shock wave region. The effect of grain size and scaling, for fixed free-stream conditions and fixed channel width, on the shock detachment is presented. The mechanisms of the static heap formation and the shock detachment process in a confined environment are discussed.
Meltwater drainage and iceberg calving observed in high-spatiotemporal resolution at Helheim Glacier, Greenland
Authors: Melton Sierra M. , Alley Richard B. , Anandakrishnan Sridhar , Parizek Byron R. , Shahin Michael G. , Stearns Leigh A. , LeWinter Adam L. , Finnegan David C.
Published: January 2022

Marine-terminating glaciers lose mass through melting and iceberg calving, and we find that meltwater drainage systems influence calving timing at Helheim Glacier, a tidewater glacier in East Greenland. Meltwater feeds a buoyant subglacial discharge plume at the terminus of Helheim Glacier, which rises along the glacial front and surfaces through the mélange. Here, we use high-resolution satellite and time-lapse imagery to observe the surface expression of this meltwater plume and how plume timing and location compare with that of calving and supraglacial meltwater pooling from 2011 to 2019. The plume consistently appeared at the central terminus even as the glacier advanced and retreated, fed by a well-established channelized drainage system with connections to supraglacial water. All full-thickness calving episodes, both tabular and non-tabular, were separated from the surfacing plume by either time or by space. We hypothesize that variability in subglacial hydrology and basal coupling drive this inverse relationship between subglacial discharge plumes and full-thickness calving. Surfacing plumes likely indicate a low-pressure subglacial drainage system and grounded terminus, while full-thickness calving occurrence reflects a terminus at or close to flotation. Our records of plume appearance and full-thickness calving therefore represent proxies for the grounding state of Helheim Glacier through time.
The father of ‘sovereignism’: d'Annunzio in Fiume between the crisis of liberalism and the critique of democracy
Authors: Serventi Longhi Enrico
Published: January 2022

The essay investigates the occupation of the city of Rijeka (1919–20) by an irregular army led by Italian poet Gabriele d'Annunzio, focusing on the concepts of sovereignism and populism. While people with different mentalities and ideological horizons took part in the endeavour, it was d'Annunzio that gave the occupation its profound meaning. The poet attempted to put into practice his political vision centered around a ‘noble people’, composed of warriors and producers, opposed to the liberal elites and in competition with revolutionary socialist movements. In this sense, the Free State of Rijeka grew into the prototype of a new society based on the integration of racial, plebiscitary, corporate, aesthetic, and political themes. At the same time, the city became a beacon of opposition to the new international order proposed by US president Woodrow Wilson, since it advocated and worked towards the birth of sovereignty for small countries resisting new supranational bodies such as the League of Nations.
Toward a generalized notion of discrete time for modeling temporal networks
Authors: Kueffner Konstantin , Strembeck Mark
Published: January 2022

Many real-world networks, including social networks and computer networks for example, are temporal networks. This means that the vertices and edges change over time. However, most approaches for modeling and analyzing temporal networks do not explicitly discuss the underlying notion of time. In this paper, we therefore introduce a generalized notion of discrete time for modeling temporal networks. Our approach also allows for considering nondeterministic time and incomplete data, two issues that are often found when analyzing datasets extracted from online social networks, for example. In order to demonstrate the consequences of our generalized notion of time, we also discuss the implications for the computation of (shortest) temporal paths in temporal networks. In addition, we implemented an R-package that provides programming support for all concepts discussed in this paper. The R-package is publicly available for download.
The influence of palaeogeography and tectonic events on trilobite distributions in Morocco and northwestern Algeria
Authors: Bault Valentin , Crônier Catherine , Bignon Arnaud
Published: January 2022

The effects of sea-level changes and anoxia on Devonian trilobites have been studied for a long time, but the importance of palaeogeographic and tectonic events in this key-period is still not well understood. In the Devonian Period, trilobites invaded many different marine environments and areas in North Africa where important palaeogeographic changes occurred. Distribution patterns of trilobites through time and space have been analysed using a hierarchical cluster analysis and diversity indices. Our examination of the literature suggests that trilobites were scarce during Lochkovian time before an important diversification in Pragian time. Trilobites flourished in many North African regions without there being important taxonomic differences between basins, because of free migration in relatively flat palaeo-topography and homogeneous environments. During Middle Devonian time, early Variscan tectonic movements transformed the eastern Anti-Atlas area into a basin with a platform topography. Geographical barriers such as deep basins prevented trilobite migrations. At the beginning of Eifelian time, the reduction in migration between the different regions of this area coincided with a decrease in diversity. Consequently, tectonic events played an important role in the decline of trilobites during Middle Devonian time, especially when these were combined with sea-level changes and anoxic/hypoxic events. A recovery occurred in Famennian time involving only new genera. As at the global scale, cyrtosymbolines developed in shallow seas, whereas phacopids evolved in deeper environments. The basin and platform system still hampered migrations, although sea-level variations led to episodic exchanges. The late Famennian regression reduced trilobite diversity dramatically in the study area.
Between Centralizing Orthodoxy and Local Self-Governance: Taiwanese Sinophone Socialism in Hong Kong, 1947–49
Authors: McConaghy Mark
Published: January 2022

This article examines the New Taiwan Series (NTS), a journal published between 1947 and 1948 in Hong Kong by Taiwanese socialists who fled the island following the 228 Uprising. It does so to intervene in ongoing debates in the field of Sinophone studies. While two major theorizations of the Sinophone exist—one that sees the field as a network of minoritized sites that operate against China-centrism, and the other grounding the Sinophone in a lyrical negotiation with cultural China—neither framework is sufficient for understanding the complex subject positions taken by Taiwanese socialists during these years. For the NTS, social activism was not a flattened binary of either ethnic identification with or resistance to a “China” articulated in terms devoid of political-economic analysis. Rather, politics had to dialectically integrate minoritarian aspirations (Taiwanese sovereignty) with majoritarian projects (the Chinese Revolution). The NTS thus encourages us to reimagine the Sinophone in socialist terms, where two analytical lenses—one grounded in the endogenous local and the other in the exogenous revolutionary center—are dialectically intertwined. The NTS navigated the resulting tensions of such a dialectical stance, making it a critical archive of Taiwanese socialist thought before the 1949 rupture.
Use of multiple polygenic risk scores for distinguishing schizophrenia-spectrum disorder and affective psychosis categories in a first-episode sample; the EU-GEI study
Authors: Rodriguez Victoria , Alameda Luis , Quattrone Diego , Tripoli Giada , Gayer-Anderson Charlotte , Spinazzola Edoardo , Trotta Giulia , Jongsma Hannah E. , Stilo Simona , La Cascia Caterina , Ferraro Laura , La Barbera Daniele , Lasalvia Antonio , Tosato Sarah , Tarricone Ilaria , Bonora Elena , Jamain Stéphane , Selten Jean-Paul , Velthorst Eva , de Haan Lieuwe , Llorca Pierre-Michel , Arrojo Manuel , Bobes Julio , Bernardo Miguel , Arango Celso , Kirkbride James , Jones Peter B. , Rutten Bart P. , Richards Alexander , Sham Pak C. , O'Donovan Michael , Van Os Jim , Morgan Craig , Di Forti Marta , Murray Robin M. , Vassos Evangelos
Published: January 2022

Background

Schizophrenia (SZ), bipolar disorder (BD) and depression (D) run in families. This susceptibility is partly due to hundreds or thousands of common genetic variants, each conferring a fractional risk. The cumulative effects of the associated variants can be summarised as a polygenic risk score (PRS). Using data from the EUropean Network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) first episode case–control study, we aimed to test whether PRSs for three major psychiatric disorders (SZ, BD, D) and for intelligent quotient (IQ) as a neurodevelopmental proxy, can discriminate affective psychosis (AP) from schizophrenia-spectrum disorder (SSD).

Methods

Participants (842 cases, 1284 controls) from 16 European EU-GEI sites were successfully genotyped following standard quality control procedures. The sample was stratified based on genomic ancestry and analyses were done only on the subsample representing the European population (573 cases, 1005 controls). Using PRS for SZ, BD, D, and IQ built from the latest available summary statistics, we performed simple or multinomial logistic regression models adjusted for 10 principal components for the different clinical comparisons.

Results

In case–control comparisons PRS-SZ, PRS-BD and PRS-D distributed differentially across psychotic subcategories. In case–case comparisons, both PRS-SZ [odds ratio (OR) = 0.7, 95% confidence interval (CI) 0.54–0.92] and PRS-D (OR = 1.31, 95% CI 1.06–1.61) differentiated AP from SSD; and within AP categories, only PRS-SZ differentiated BD from psychotic depression (OR = 2.14, 95% CI 1.23–3.74).

Conclusions

Combining PRS for severe psychiatric disorders in prediction models for psychosis phenotypes can increase discriminative ability and improve our understanding of these phenotypes. Our results point towards the potential usefulness of PRSs in specific populations such as high-risk or early psychosis phases.
Occupied Istanbul as a Cominternian Hub: Sailors, Soldiers, and Post-Imperial Networks (1918–1923)
Authors: Sayım Burak
Published: January 2022

Between 1918 and 1923, Istanbul was the capital of a defeated empire and occupied by the “interallied” forces composed of Britain, France, and Italy. Notwithstanding, or precisely due to, these conditions, it functioned as a vibrant hub of global communist militancy. This article explores the brief history of occupied Istanbul and discusses different agents and aspects of communist network-making. It underlines the agency of two neglected actors: a multinational body of communist sailors who connected Istanbul and its communists to European, Middle Eastern, and Soviet ports; and European and colonial soldiers stationed in Istanbul, who counterintuitively contributed to these connections. Finally, it shows how Istanbul, as the multiethnic and multilinguistic soon-to-be-former capital of the Ottoman Empire, provided a fertile ground for communist connections.
Caregiver–child proximity as a dimension of early experience
Authors: Barnett Whitney , Hansen Clare L. , Bailes Lauren G. , Humphreys Kathryn L.
Published: January 2022

Human infancy and early childhood is both a time of heightened brain plasticity and responsivity to the environment as well as a developmental period of dependency on caregivers for survival, nurturance, and stimulation. Across primate species and human evolutionary history, close contact between infants and caregivers is species-expected. As children develop, caregiver–child proximity patterns change as children become more autonomous. In addition to developmental changes, there is variation in caregiver–child proximity across cultures and families, with potential implications for child functioning. We propose that caregiver–child proximity is an important dimension for understanding early environments, given that interactions between children and their caregivers are a primary source of experience-dependent learning. We review approaches for operationalizing this construct (e.g., touch, physical distance) and highlight studies that illustrate how caregiver–child proximity can be measured. Drawing on the concepts proposed in dimensional models of adversity, we consider how caregiver–child proximity may contribute to our understanding of children’s early experiences. Finally, we discuss future directions in caregiver–child proximity research with the goal of understanding the link between early experiences and child adaptive and maladaptive functioning.
Latent classes of oppositional defiant disorder in adolescence and prediction to later psychopathology
Authors: Racz Sarah J. , McMahon Robert J. , Gudmundsen Gretchen , McCauley Elizabeth , Vander Stoep Ann
Published: January 2022

Current conceptualizations of oppositional defiant disorder (ODD) place the symptoms of this disorder within three separate but related dimensions (i.e., angry/irritable mood, argumentative/defiant behavior, vindictiveness). Variable-centered models of these dimensions have yielded discrepant findings, limiting their clinical utility. The current study utilized person-centered latent class analysis based on self and parent report of ODD symptomatology from a community-based cohort study of 521 adolescents. We tested for sex, race, and age differences in the identified classes and investigated their ability to predict later symptoms of depression and conduct disorder (CD). Diagnostic information regarding ODD, depression, and CD were collected annually from adolescents (grades 6–9; 51.9% male; 48.7% White, 28.2% Black, 18.5% Asian) and a parent. Results provided evidence for three classes of ODD (high, medium, and low endorsement of symptoms), which demonstrated important developmental differences across time. Based on self-report, Black adolescents were more likely to be in the high and medium classes, while according to parent report, White adolescents were more likely to be in the high and medium classes. Membership in the high and medium classes predicted later increases in symptoms of depression and CD, with the high class showing the greatest risk for later psychopathology.
Is More Better? Effects of Newsroom and Audience Diversity on Trait Coverage of Minority Candidates
Authors: Sui Mingxiao , Paul Newly
Published: January 2022

This article examines how the racial composition of newsrooms and that of the news audiences influence campaign coverage of candidates. Using observational data compiled from multiple sources for analyses, our findings suggest that candidate trait coverage is influenced by what we term racial congruence at two levels. First, when the number of non-white journalists increases in newsroom, white candidates are more likely to receive positive trait coverage than non-white candidates, which is likely compounded by multiple constraints racial minority journalists face in the newsroom. This racial congruence phenomenon is also present in areas with large non-white adult populations. The larger this population, the higher is favorable news coverage for non-white candidates compared to white candidates. The race of candidates, journalists, and audiences does not have a combined effect on news coverage, indicating that the effects of more diverse newsroom members are not necessarily driven by market incentives.
Conducting Clinical Trials in Twin Populations: A Review of Design, Analysis, Recruitment and Ethical Issues for Twin-Only Trials
Authors: Yelland Lisa N. , Scurrah Katrina J. , Ferreira Paulo , Calais-Ferreira Lucas , Rankin Monica , Denton Jane , Harvey Merryl , Lee Katherine J. , Kendal Evie , Craig Jeffrey M.
Published: January 2022

Although twins often participate in medical research, few clinical trials are conducted entirely in twin populations. The purpose of this review is to demonstrate the substantial benefits and address the key challenges of conducting clinical trials in twin populations, or ‘twin-only trials’. We consider the unique design, analysis, recruitment and ethical issues that arise in such trials. In particular, we describe the different approaches available for randomizing twin pairs, highlight the similarity or correlation that exists between outcomes of twins, and discuss the impact of this correlation on sample size calculations and statistical analysis methods for estimating treatment effects. We also consider the role of both monozygotic and dizygotic twins for studying variation in outcomes, the factors that may affect recruitment of twins, and the ethics of conducting trials entirely in twin populations. The advantages and disadvantages of conducting twin-only trials are also discussed. Finally, we recommend that twin-only trials should be considered more often.
Single‐ and Multi‐Pass Magnetometric Subsurface Ocean Detection and Characterization in Icy Worlds Using Principal Component Analysis (PCA): Application to Triton
Authors: Cochrane C. J. , Persinger R. R. , Vance S. D. , Midkiff E. L. , Castillo‐Rogez J. , Luspay‐Kuti A. , Liuzzo L. , Paty C. , Mitchell K. L. , Prockter L. M.
Published: January 2022

Many moons in the solar system are thought to potentially harbor hidden oceans based on the features observed at their surfaces. However, the magnetic induction signatures measured in the vicinity of these moons provide the most compelling evidence for the presence of a subsurface ocean, specifically for the Jovian moons Europa and Callisto. Interpretation of these magnetic signatures can be challenging due to the various systematic and random sources of noise that are present in the magnetic field measurement. In this work, a novel magnetometric ocean detection methodology based on Principal Component Analysis is presented and shown to provide enhanced discrimination and geophysical characterization of ocean properties in the presence of noise and error sources. The proposed methodology is robust for a single‐encounter mission or an orbiting mission with multiple flybys. Here, it is applied to the Neptunian moon Triton as a prime example of an active, potential ocean world residing in the requisite time‐varying magnetic field environment that enables magnetic induction investigation of its interior. In addition to the usual noise sources, other confounding factors are addressed, including the presence of an intense conductive ionosphere, the small amplitude of Neptune's driving magnetic field, and the uncertainty of Neptune's magnetic phase at the time‐of‐arrival which can potentially hinder accurate ocean detection and characterization. The proposed methodology is applicable to any moon in the solar system residing in a time‐varying magnetic field environment.
Machine Learning‐Based Model for Real‐Time GNSS Precipitable Water Vapor Sensing
Authors: Zheng Yuxin , Lu Cuixian , Wu Zhilu , Liao Jianchi , Zhang Yushan , Wang Qiuyi
Published: January 2022

Global Navigation Satellite Systems (GNSS) provide a promising opportunity for real‐time precipitable water vapor (PWV) sensing. However, relying on meteorological information restrains the implementation of real‐time inversion from tropospheric zenith total delays (ZTD) into PWV. In this study, a stacked machine learning model for mapping ZTD into PWV in the absence of meteorological parameters is developed. The model performance is assessed and validated with information offered by fifth generation European Centre for Medium‐Range Weather Forecasts reanalysis (ERA5) and radiosondes. An accuracy of better than 2.5 mm is achievable for the PWV values. Compared to the physical model which applies GPT3‐derived meteorological parameters, the proposed model reveals an enhanced performance, especially in the high‐latitude regions, with improvements of 28.1% and 22.2% when validated with ERA5 and radiosondes. This model is capable of fulfilling the demands of time‐critical meteorological applications and is also promising for real‐time PWV retrieval of other techniques that own the capability to sense ZTD.
Nonlinear Responses of Droughts Over China to Volcanic Eruptions at Different Drought Phases
Authors: Chen Kefan , Ning Liang , Liu Zhengyu , Liu Jian , Yan Mi , Sun Weiyi , Yuan Linwang , Lv Guonian , Li Longhui , Jin Chunhan , Shi Zhengguo
Published: January 2022

Previous studies show that volcanic eruptions can intensify and extend drought events triggered by internal variability over Eastern China. However, it has remained unclear whether volcanic eruptions occurring in different drought phases have different impacts. Here, based on multiple reconstructions, simulations, as well as volcanic sensitivity experiments with volcanic forcing imposed in the early and late phases of droughts, we propose a nonlinear effect of volcanic eruptions on drought events. Late‐phase volcanic eruptions exert greater impact on drought persistence and intensity while early‐phase volcanic eruptions induce modest and weaker impacts. The evolutions of drought differ substantially from the typical volcanic‐only influence or the linear combination of the drought triggered by internal variability and volcanic‐only influences, which are hypothesized to be associated with positive feedbacks of soil moisture to precipitation, as well as its interaction with the evolution of the East Asia Summer monsoon.
Ocean Response in Transient Simulations of the Last Deglaciation Dominated by Underlying Ice‐Sheet Reconstruction and Method of Meltwater Distribution
Authors: Kapsch Marie‐Luise , Mikolajewicz Uwe , Ziemen Florian , Schannwell Clemens
Published: January 2022

The last deglaciation was characterized by drastic climate changes, most prominently melting ice sheets. Melting ice sheets have a significant impact on the atmospheric and oceanic circulation, due to changes in the topography and meltwater release into the ocean. In a set of transient simulations of the last deglaciation with the Max Planck Institute for Meteorology Earth System Model we explore differences in the climate response that arise from different boundary conditions and implementations suggested within the Paleoclimate Modeling Intercomparison Project ‐ Phase 4 (PMIP4) deglaciation protocol. The underlying ice‐sheet reconstruction dominates the simulated deglacial millennial‐scale climate variability in terms of timing and occurrence of observed climate events. Sensitivity experiments indicate that the location and timing of meltwater release from the ice sheets into the ocean are crucial for the ocean response. The results will allow a better interpretation of inter‐model differences that arise from different implementations proposed within the PMIP4 protocol.
Syntectonic Sediment Recycling Controls Eolian Deposition in Eastern Asia Since ∼8 Ma
Authors: Lu Haijian , Malusà Marco G. , Zhang Zhiyong , Guo Licheng , Shi Xuhua , Ye Jiacan , Sang Shengping , Xiong Shangfa , Pan Jiawei , Li Haibing
Published: January 2022

Global cooling and/or Tibetan Plateau uplift have long been regarded as the principal drivers of late Cenozoic central Asian aridification and the resulting widespread accumulation of eolian deposits in eastern Asia. However, these two factors are unable to form large source areas of fine‐grained sediments enhancing eolian deposition synchronously from northern Tibet to North Pacific. Here we provide magnetostratigraphic and detrital apatite fission‐track evidence for a major sediment recycling event in northern Tibet at ∼8 Ma, coeval with a sudden increase in eolian deposition, which we ascribe to syntectonic erosion of uplifted friable fluvio‐lacustrine sediments and selective entrainment by the westerly winds during basin deformation. Our results emphasize the importance of widespread and persistent occurrence of fine‐grained sediments along the pathway of westerlies to produce voluminous dust deposits. These findings suggest that the onset of eolian deposition may not be directly related to global cooling or uplift of mountain ranges.
Solitary Magnetic Structures Developed From Gyro‐Resonance With Solar Wind Ions at Mars and Earth
Authors: Chen Li‐Jen , Halekas Jasper , Wang Shan , DiBraccio Gina A. , Romanelli Norberto , Ng Jonathan , Russell Christopher T. , Schwartz Steven J. , Sibeck David G. , Farrell William , Pollock Craig , Gershman Daniel , Giles Barbara , Collado‐Vega Yaireska M.
Published: January 2022

We investigate solitary magnetic structures in the foreshock of Mars and Earth. The structures exhibit pulse‐like magnetic field and density enhancements along with plasma heating and local solar wind (SW) ion reflection. The structures at Mars resemble the foreshock structures developed from ultra‐low‐frequency electromagnetic waves gyro‐resonant with SW ions at Earth, and propagate toward the magnetosphere. We perform fully kinetic simulations to reproduce the solitary structures and the nonlinear evolution of ion distribution functions, illustrating their resonance with SW ions. The structures present self‐induced foreshock turbulence that can have space weather effects. Our results advance the fundamental understanding of how SW interacts with planetary magnetospheres, and have potential impact on the current picture of planet‐origin ion escape.
Transports and Pathways of the Tropical AMOC Return Flow From Argo Data and Shipboard Velocity Measurements
Authors: Tuchen Franz Philip , Brandt Peter , Lübbecke Joke F. , Hummels Rebecca
Published: January 2022

The upper‐ocean circulation of the tropical Atlantic is a complex superposition of thermohaline and wind‐driven flow components. The resulting zonally and vertically integrated upper‐ocean meridional flow is referred to as the upper branch of the Atlantic Meridional Overturning Circulation (AMOC)—a major component and potential tipping element of the global climate system. Here, we investigate the tropical part of the northward AMOC branch, that is, the return flow covering the upper 1,200 m, based on Argo data and repeated shipboard velocity measurements. The western boundary mean circulation at 11°S is realistically reproduced from high‐resolution Argo data showing a remarkably good representation of the volume transport of the return flow water mass layers when compared to results from direct velocity measurements along a repeated ship section. The AMOC return flow through the inner tropics (11°S–10°N) is found to be associated with a diapycnal upwelling of lower central water into the thermocline layer of ∼2 Sv. This is less than half the magnitude of previous estimates, likely due to improved horizontal resolution. The total AMOC return flow at 11°S and 10°N is derived to be similar in strength with 16–17 Sv. At 11°S, northward transport is concentrated at the western boundary, where the AMOC return flow enters the inner tropics at all vertical levels above 1,200 m. At 10°N, northward transport is observed both at the western boundary and in the interior predominantly in the surface and intermediate layer indicating recirculation and transformation of thermocline and lower central water within the inner tropics.
Changes in Great Plains Low‐Level Jet Structure and Associated Precipitation Over the 20th Century
Authors: Ferguson Craig R.
Published: January 2022

The U.S. Great Plains warm season climate is inextricably linked to the frequency and structure of the region's southerly low‐level jet. In the present‐day climate (1977–2009), low‐level jets are shown to occur on 26%, 46%, and 62% of May–September days in the northern (NGP), central (CGP) and southern (SGP) Great Plains, respectively, and account for at least 26%, 25%, and 36% of those region's precipitation during the same period. A shortcoming of previous research has been a failure to treat upper‐level dynamically coupled, or cyclone‐induced jets, separately from jets that are relatively uncoupled from synoptic flow. Differentiating between jet types is essential to proper mechanistic diagnosis and attribution of jet‐related wind, precipitation, and temperature changes to their local land or remote oceanic forcing. Using a new CERA‐20C objective dynamical jet classification dataset, this study achieves the first quantitative assessment of changes in coupled and uncoupled jets between 1901 and 2010 for NGP, CGP, and SGP. Declines in warm season jet frequency are pinpointed to July–September jets. In the NGP and CGP, both jet types have undergone significant increases in speed and height with concomitant decreases in CAPE and precipitation. NGP uncoupled jet and CGP coupled jet precipitation has decreased by 0.5 and 0.8 mm day−1, respectively, which accounts for 41%–44% of total May–September precipitation decreases between 1905–1937 and 1977–2009. A dynamic situation in which synoptic and local soil moisture changes drive opposite jet responses is discussed.
Impact of Displacement Direction Relative to Heterogeneity on Averaged Capillary Pressure‐Saturation Curves
Authors: Shokri Javad , Godinez‐Brizuela Omar E. , Erfani Hamidreza , Chen Yongqiang , Babaei Masoud , Berkowitz Brian , Niasar Vahid
Published: January 2022

The capillary pressure‐saturation relation is one of the key constitutive equations used for modeling multiphase (or partially saturated) flow in porous materials. It is known that this empirical relation depends strongly on dynamic conditions, but the impact of a heterogeneity interface on this relationship has been studied less. The present study employed optical imaging to visualize two‐phase drainage under different injection rates and two flow directions, in a heterogeneous micromodel. By analyzing the curvatures of the fluid‐fluid interfaces, the averaged capillary pressures for the coarse and fine sections of the micromodel, and the entire micromodel were estimated. Results show that the capillary pressure‐saturation relation in the vicinity of a heterogeneity interface does not follow the conventional models proposed in the literature. The averaged capillary pressure over the entire micromodel for the fine‐to‐coarse (FtC) direction shows decreasing capillary pressure with decreasing wetting phase saturation. However, in the coarse‐to‐fine direction, a non‐monotonic trend was observed. These initial findings highlight the gaps in the knowledge of upscaling capillary pressure in heterogeneous porous materials. Moreover, discontinuity in saturation was clearly more pronounced for the FtC direction, as a result of lower entry capillary resistance against the flow in the coarse section.
The Century-Old Renewable You’ve Never Heard Of
Authors: Betancourt Mark
Published: January 2022

Ocean thermal energy conversion could power the world’s tropical islands, if it ever gets out of the “innovation valley of death.”
Developmental oxidative stress leads to T-type Ca2+ channel hypofunction in thalamic reticular nucleus of mouse models pertinent to schizophrenia
Authors: El Khoueiry Corinne , Cabungcal Jan-Harry , Rovó Zita , Fournier Margot , Do Kim Q. , Steullet Pascal
Published: January 2022

Impairment of parvalbumin interneurons induced by oxidative stress (OxS) is a “hub” on which converge several genetic and environmental risk factors associated with schizophrenia. In patients, this could be a mechanism leading to anomalies of the thalamic reticular nucleus (TRN) whose major neuronal population expresses parvalbumin. The TRN shapes the information flow within thalamo-cortical circuits. The low-threshold voltage-gated T-type Ca2+ (T-Ca2+) channels (CaV3.2, CaV3.3) contribute to the excitability and rhythmic bursting of TRN neurons which mediates cortical sleep spindles, known to be affected in schizophrenia. Here, we investigated the impact of OxS during postnatal development and adulthood on firing properties and T-Ca2+ channels of TRN neurons. In Gclm knock-out (KO) mice, which display GSH deficit and OxS in TRN, we found a reduction of T-Ca2+ current density in adulthood, but not at peripuberty. In KO adults, the decreased T-Ca2+ currents were accompanied with a decrease of CaV3.3 expression, and a shift towards more hyperpolarized membrane potentials for burst firing leading to less prominent bursting profile. In young KO mice, an early-life oxidative challenge precipitated the hypofunction of T-Ca2+ channels. This was prevented by a treatment with N-acetylcysteine. The concomitant presence of OxS and hypofunction of T-Ca2+ channels were also observed in TRN of a neurodevelopmental model relevant to psychosis (MAM mice). Collectively, these data indicate that OxS-mediated T-Ca2+ hypofunction in TRN begins early in life. This also points to T-Ca2+ channels as one target of antioxidant-based treatments aiming to mitigate abnormal thalamo-cortical communication and pathogenesis of schizophrenia.
A genome-wide association study of serum proteins reveals shared loci with common diseases
Authors: Gudjonsson Alexander , Gudmundsdottir Valborg , Axelsson Gisli T. , Gudmundsson Elias F. , Jonsson Brynjolfur G. , Launer Lenore J. , Lamb John R. , Jennings Lori L. , Aspelund Thor , Emilsson Valur , Gudnason Vilmundur
Published: January 2022

With the growing number of genetic association studies, the genotype-phenotype atlas has become increasingly more complex, yet the functional consequences of most disease associated alleles is not understood. The measurement of protein level variation in solid tissues and biofluids integrated with genetic variants offers a path to deeper functional insights. Here we present a large-scale proteogenomic study in 5,368 individuals, revealing 4,035 independent associations between genetic variants and 2,091 serum proteins, of which 36% are previously unreported. The majority of both cis- and trans-acting genetic signals are unique for a single protein, although our results also highlight numerous highly pleiotropic genetic effects on protein levels and demonstrate that a protein’s genetic association profile reflects certain characteristics of the protein, including its location in protein networks, tissue specificity and intolerance to loss of function mutations. Integrating protein measurements with deep phenotyping of the cohort, we observe substantial enrichment of phenotype associations for serum proteins regulated by established GWAS loci, and offer new insights into the interplay between genetics, serum protein levels and complex disease.
PHOSPHATE STARVATION RESPONSE transcription factors enable arbuscular mycorrhiza symbiosis
Authors: Das Debatosh , Paries Michael , Hobecker Karen , Gigl Michael , Dawid Corinna , Lam Hon-Ming , Zhang Jianhua , Chen Moxian , Gutjahr Caroline
Published: January 2022

Arbuscular mycorrhiza (AM) is a widespread symbiosis between roots of the majority of land plants and Glomeromycotina fungi. AM is important for ecosystem health and functioning as the fungi critically support plant performance by providing essential mineral nutrients, particularly the poorly accessible phosphate, in exchange for organic carbon. AM fungi colonize the inside of roots and this is promoted at low but inhibited at high plant phosphate status, while the mechanistic basis for this phosphate-dependence remained obscure. Here we demonstrate that a major transcriptional regulator of phosphate starvation responses in rice PHOSPHATE STARVATION RESPONSE 2 (PHR2) regulates AM. Root colonization of phr2 mutants is drastically reduced, and PHR2 is required for root colonization, mycorrhizal phosphate uptake, and yield increase in field soil. PHR2 promotes AM by targeting genes required for pre-contact signaling, root colonization, and AM function. Thus, this important symbiosis is directly wired to the PHR2-controlled plant phosphate starvation response.
Focused ultrasound excites cortical neurons via mechanosensitive calcium accumulation and ion channel amplification
Authors: Yoo Sangjin , Mittelstein David R. , Hurt Robert C. , Lacroix Jerome , Shapiro Mikhail G.
Published: January 2022

Ultrasonic neuromodulation has the unique potential to provide non-invasive control of neural activity in deep brain regions with high spatial precision and without chemical or genetic modification. However, the biomolecular and cellular mechanisms by which focused ultrasound excites mammalian neurons have remained unclear, posing significant challenges for the use of this technology in research and potential clinical applications. Here, we show that focused ultrasound excites primary murine cortical neurons in culture through a primarily mechanical mechanism mediated by specific calcium-selective mechanosensitive ion channels. The activation of these channels results in a gradual build-up of calcium, which is amplified by calcium- and voltage-gated channels, generating a burst firing response. Cavitation, temperature changes, large-scale deformation, and synaptic transmission are not required for this excitation to occur. Pharmacological and genetic inhibition of specific ion channels leads to reduced responses to ultrasound, while over-expressing these channels results in stronger ultrasonic stimulation. These findings provide a mechanistic explanation for the effect of ultrasound on neurons to facilitate the further development of ultrasonic neuromodulation and sonogenetics as tools for neuroscience research.
Fragmentation in turbulence by small eddies
Authors: Qi Yinghe , Tan Shiyong , Corbitt Noah , Urbanik Carl , Salibindla Ashwanth K. R. , Ni Rui
Published: January 2022

From air-sea gas exchange, oil pollution, to bioreactors, the ubiquitous fragmentation of bubbles/drops in turbulence has been modeled by relying on the classical Kolmogorov-Hinze paradigm since the 1950s. This framework hypothesizes that bubbles/drops are broken solely by eddies of the same size, even though turbulence is well known for its wide spectrum of scales. Here, by designing an experiment that can physically and cleanly disentangle eddies of various sizes, we report the experimental evidence to challenge this hypothesis and show that bubbles are preferentially broken by the sub-bubble-scale eddies. Our work also highlights that fragmentation cannot be quantified solely by the stress criterion or the Weber number; The competition between different time scales is equally important. Instead of being elongated slowly and persistently by flows at their own scales, bubbles are fragmented in turbulence by small eddies via a burst of intense local deformation within a short time.
Antisite defect qubits in monolayer transition metal dichalcogenides
Authors: Tsai Jeng-Yuan , Pan Jinbo , Lin Hsin , Bansil Arun , Yan Qimin
Published: January 2022

Being atomically thin and amenable to external controls, two-dimensional (2D) materials offer a new paradigm for the realization of patterned qubit fabrication and operation at room temperature for quantum information sciences applications. Here we show that the antisite defect in 2D transition metal dichalcogenides (TMDs) can provide a controllable solid-state spin qubit system. Using high-throughput atomistic simulations, we identify several neutral antisite defects in TMDs that lie deep in the bulk band gap and host a paramagnetic triplet ground state. Our in-depth analysis reveals the presence of optical transitions and triplet-singlet intersystem crossing processes for fingerprinting these defect qubits. As an illustrative example, we discuss the initialization and readout principles of an antisite qubit in WS2, which is expected to be stable against interlayer interactions in a multilayer structure for qubit isolation and protection in future qubit-based devices. Our study opens a new pathway for creating scalable, room-temperature spin qubits in 2D TMDs.
Improved gRNA secondary structures allow editing of target sites resistant to CRISPR-Cas9 cleavage
Authors: Riesenberg Stephan , Helmbrecht Nelly , Kanis Philipp , Maricic Tomislav , Pääbo Svante
Published: January 2022

The first step in CRISPR-Cas9-mediated genome editing is the cleavage of target DNA sequences that are complementary to so-called spacer sequences in CRISPR guide RNAs (gRNAs). However, some DNA sequences are refractory to CRISPR-Cas9 cleavage, which is at least in part due to gRNA misfolding. To overcome this problem, we have engineered gRNAs with highly stable hairpins in their constant parts and further enhanced their stability by chemical modifications. The ‘Genome-editing Optimized Locked Design’ (GOLD)-gRNA increases genome editing efficiency up to around 1000-fold (from 0.08 to 80.5%) with a mean increase across different other targets of 7.4-fold. We anticipate that this improved gRNA will allow efficient editing regardless of spacer sequence composition and will be especially useful if a desired genomic site is difficult to edit.
Polyamide-based membranes with structural homogeneity for ultrafast molecular sieving
Authors: Shen Liang , Cheng Ruihuan , Yi Ming , Hung Wei-Song , Japip Susilo , Tian Lian , Zhang Xuan , Jiang Shudong , Li Song , Wang Yan
Published: January 2022

Thin-film composite membranes formed by conventional interfacial polymerization generally suffer from the depth heterogeneity of the polyamide layer, i.e., nonuniformly distributed free volume pores, leading to the inefficient permselectivity. Here, we demonstrate a facile and versatile approach to tune the nanoscale homogeneity of polyamide-based thin-film composite membranes via inorganic salt-mediated interfacial polymerization process. Molecular dynamics simulations and various characterization techniques elucidate in detail the underlying molecular mechanism by which the salt addition confines and regulates the diffusion of amine monomers to the water-oil interface and thus tunes the nanoscale homogeneity of the polyamide layer. The resulting thin-film composite membranes with thin, smooth, dense, and structurally homogeneous polyamide layers demonstrate a permeance increment of ~20–435% and/or solute rejection enhancement of ~10–170% as well as improved antifouling property for efficient reverse/forward osmosis and nanofiltration separations. This work sheds light on the tunability of the polyamide layer homogeneity via salt-regulated interfacial polymerization process.
A combination of multiple autoantibodies is associated with the risk of Alzheimer’s disease and cognitive impairment
Authors: Shim Sung-Mi , Koh Young Ho , Kim Jong-Hoon , Jeon Jae-Pil
Published: January 2022

Autoantibodies are self-antigen reactive antibodies that play diverse roles in the normal immune system, tissue homeostasis, and autoimmune and neurodegenerative diseases. Anti-neuronal autoantibodies have been detected in neurodegenerative disease serum, with unclear significance. To identify diagnostic biomarkers of Alzheimer’s disease (AD), we analyzed serum autoantibody profiles of the HuProt proteome microarray using the discovery set of cognitively normal control (NC, n = 5) and AD (n = 5) subjects. Approximately 1.5-fold higher numbers of autoantibodies were detected in the AD group (98.0 ± 39.9/person) than the NC group (66.0 ± 39.6/person). Of the autoantigen candidates detected in the HuProt microarray, five autoantigens were finally selected for the ELISA-based validation experiment using the validation set including age- and gender-matched normal (NC, n = 44), mild cognitive impairment (MCI, n = 44) and AD (n = 44) subjects. The serum levels of four autoantibodies including anti-ATCAY, HIST1H3F, NME7 and PAIP2 IgG were significantly different among NC, MCI and/or AD groups. Specifically, the anti-ATCAY autoantibody level was significantly higher in the AD (p = 0.003) and MCI (p = 0.015) groups compared to the NC group. The anti-ATCAY autoantibody level was also significantly correlated with neuropsychological scores of MMSE (rs = − 0.229,p = 0.012), K-MoCA (rs = − 0.270,p = 0.003), and CDR scores (rs = 0.218,p = 0.016). In addition, a single or combined occurrence frequency of anti-ATCAY and anti-PAIP2 autoantibodies was significantly associated with the risk of MCI and AD. This study indicates that anti-ATCAY and anti-PAIP2 autoantibodies could be a potential diagnostic biomarker of AD.
Effects of root restriction on phytohormone levels in different growth stages and grapevine organs
Authors: Li Jiajia , Li Dongmei , Liu Boyang , Wang Ruiqi , Yan Yixuan , Li Guanhan , Wang Lei , Ma Chao , Xu Wenping , Zhao Liping , Li Xiangyi , Wang Shiping
Published: January 2022

Phytohormones play important roles in germination, blossom, senescence, abscission of plants by a series of signal transduction and molecular regulation. The purpose of this research was to investigate the influence of root restriction (RR) cultivation on plant endogenous hormone variation tendency at different growth stages in diverse organs or tissues. ‘Muscat Hamburg’ (Vitis ‘Muscat of Alexandria’ × Vitis ‘Trollinger’) grapevine was used as test material. High Performance Liquid Chromatography (HPLC) was used to quantify hormone levels, qRT-PCR was used to quantify the expression of genes related to hormone biosynthesis pathway, and determined parameters of growth and photosynthetic, aiming to investigate the influence of root restriction on the formation and metabolism of phytohormones, as well as the degree of correlation between phytohormones and plant growth and photosynthetic intensity under root restriction. By measuring the photosynthetic rate of leaves at the stages of core-hardening, veraison and maturity, it was found that root restriction could reduce most photosynthetic parameters. The results also revealed that RR treatment increased abscisic acid (ABA), salicylic acid (SA), zeatin riboside (ZR), N6-(delta 2-isopentenyl)-adenine nucleoside (iPR) concentrations, while reduced auxin (IAA), 3-indolepropionic acid (IPA), 3-indolebutyric acid (IBA), gibberellin A3(GA3), zeatin (ZT), N6-(delta 2-Isopentenyl)-adenine (iP), kinetin (KT), jasmonic acid (JA) and methyl jasmonate (MeJA) concentrations in most organs and at most developmental stages. RT-qPCR was carried out to further explore the effect of root restriction on genes expression of ABA, SA and IAA biosynthesis pathways at molecular level. Meanwhile, through correlation analysis, we found that different phytohormones contributed differently to physiological indicators, there existed strong correlation of ABA, KT, MeJA, iPR, SA, JA with leaf photosynthesis, GA3, IBA, ZR, IAA, ZT with fruit quality. In addition, we also found that the shoot growth related parameters were closely correlated with JA, IPA and iP. To sum up, our results suggested that RR treatment could significantly increase soluble solid content, regulate the growth and photosynthesis of grapevine, by affecting the biosynthesis of phytohormones. It could further prove that root restriction was a feasible technique to ameliorate the phenomenon of low quality in grape berry in southern China.