bluuebunny/crossref_metadata_2025 huggingface dataset:
Electrocardiographic interpretation by emergency medical services professionals in Saudi Arabia: A cross sectional study
Authors: Alalwan Mohammed Abdullah , Alshammari Talal , Alawjan Hassan , Alkhayat Hassan , Alsaleh Ahmed , Alamri Ibrahim , Aldubaikel Alaa , Alqahtani Jaber , Alrawashdeh Ahmad , Alqahtani Saeed
Published: October 2023

Background

Management of acute myocardial infarction (AMI) and cardiac arrhythmias in prehospital settings is largely determined by providers of emergency medical services (EMS) who can proficiently interpret the electrocardiography (ECG). The aim of this study was to assess the ECG competency of EMS providers in Saudi Arabia.

Methods

Between Aug and Sep 2022, we invited all EMS providers working for the Saudi Red Crescent Authority in Makkah, Riyadh, and Sharqiyah regions to complete a cross-sectional survey. The survey was used to assess the ability of EMS providers to interpret 12 ECG strips. Characteristics and ECG competency were summarized using descriptive statistics. Differences in ECG competency across paramedics with lower and higher qualifications were assessed.

Results

During the study period, 231 participants completed the survey, and all were included. The overall mean age was 33.4, and most participants were male (94.8%). Nearly half of the participants were paramedics with an associate degree and 46.4% were paramedics with higher degrees. The average rate of correct answers to the 12 ECG strips was 43.3% (95% CI: 35.4%, 51.3%). Atrial flutter, ventricular fibrillation, atrial fibrillation, 3rddegree heart block, and ventricular tachycardia were identified by 52.8%, 60.2%, 42.0%, 40.7%, and 49.4% of the participants, respectively. The strip with an AMI was identified by 41.1%, while a pathological Q wave and ventricular extrasystole were identified by 19.1% and 24.7%, respectively. Paramedics with higher qualifications were as 28.0%-61.0% more likely to correctly interpret the 12 ECG strips compared to those with an associate degree (p-value across all variables was ≤ 0.001).

Conclusion

While the majority of participants in our region were unable to correctly answer the 12 ECG questionnaire, paramedics with higher qualifications were. Our study indicates that there is a need for evidenced-based ECG curricula targeting different levels of EMS professionals.
Virtual covariance matrix reconstruction-based adaptive beamforming for small aperture array
Authors: Chang Lin , Zhang Hao , Yang Hua , Lv Tingting , Tang Ning
Published: October 2023

Recently, many robust adaptive beamforming (RAB) algorithms have been proposed to improve beamforming performance when model mismatches occur. For a uniform linear array, a larger aperture array can obtain higher array gain for beamforming when the inter-sensor spacing is fixed. However, only the small aperture array can be used in the equipment limited by platform installation space, significantly weakening beamforming output performance. This paper proposes two beamforming methods for improving beamforming output in small aperture sensor arrays. The first method employs an integration algorithm that combines angular sector and gradient vector search to reconstruct the interference covariance matrix (ICM). Then, the interference-plus-noise covariance matrix (INCM) is reconstructed combined with the estimated noise power. The INCM and ICM are used to optimize the desired signal steering vector (SV) by solving a quadratically constrained quadratic programming (QCQP) problem. The second method proposes a beamforming algorithm based on a virtual extended array to increase the degree of freedom of the beamformer. First, the virtual conjugated array element is designed based on the structural characteristics of a uniform linear array, and received data at the virtual array element are obtained using a linear prediction method. Then, the extended INCM is reconstructed, and the desired signal SV is optimized using an algorithm similar to the actual array. The simulation results demonstrate the effectiveness of the proposed methods under different conditions.
tRF-003634 alleviates adriamycin-induced podocyte injury by reducing the stability of TLR4 mRNA
Authors: Gao Xiaoqing , Qiao Yunyang , Li Shanwen , Shi Huimin , Qu Gaoting , Ji Jialing , Gan Weihua , Zhang Aiqing
Published: October 2023

Podocyte injury plays a key role in the production of proteinuria and is closely related to the progression of chronic kidney disease (CKD). Alleviating podocyte injury is beneficial to prevent the occurrence and development of CKD. tRNA-derived RNA fragments (tRFs) are associated with podocytes injury processes such as protein binding, cell adhesion, synapses, the actin cytoskeleton. Our previous data showed that tRF-003634 tightly correlated with podocyte injury, while its effect remains unclear. This study aimed to investigate the role of tRF-003634 in podocyte injury and the potential mechanisms. The expression level of tRF-003634, nephrin, podocin and tRF-003634 targeted toll-like receptor 4 (TLR4) in podocytes and kidney tissues were examined by quantitative real-time PCR (qRT-PCR), western blot and immunohistochemistry. The biochemical indices were monitored and renal pathological changes were assessed by hematoxylin and eosin PAS staining. Furthermore, potential target genes of tRF-003634 were screened using high-throughput mRNA sequencing, and then confirmed by RNA pulse-chase analysis. The results showed that tRF-003634 was downregulated in adriamycin (Adr)-induced podocyte injury. Overexpression of tRF-003634 increased the expression of nephrin and podocin in vivo and in vitro and alleviated podocyte injury. Meanwhile, overexpression of tRF-003634 alleviated proteinuria and renal pathological damage. In addition, high-throughput sequencing after overexpression of tRF-003634 showed that TLR4 might be a downstream target gene. tRF-003634 can alleviate podocyte injury by reducing the stability of TLR4 mRNA, possibly by competing with TLR4 mRNA to bind to YTH domain-containing protein 1 (YTHDC1). In conclusion, tRF-003634 was underexpressed in Adr-induced podocyte injury, and its overexpression alleviated podocyte injury in vitro and in vivo by reducing the stability of TLR4 mRNA.
Experiences of living without a sense of smell: Like “Being Behind Glass”
Authors: Stafford Lorenzo D. , Nunkoosing Karl , Haydon-Laurelut Mark , Fisher Michael
Published: October 2023

This study addresses the paucity of research concerning the subjective experiences of those affected by anosmia. In the study, we interviewed individuals(n = 11) recruited via the charity (Fifth Sense) and used Interpretative Phenomenological Analysis (IPA) to analyse the data. Findings revealed three main themes and seven sub themes. The main themes are Living with Anosmia; Remembrance of things old and new and Resilience. The study reveals the process of becoming aware of being anosmic and the relationships with others in this process including potentially unhelpful minimisations of the impact by professionals. In addition to a sense of isolation and insecurity, living with anosmia for some participants brought with it an identification of being ‘anosmic’ and feeling part of a community. This was in contrast to a general lack of public knowledge and understanding of anosmia. The findings of the study demonstrated the importance of smell to time, place and relationship and the recalling of smells as bringing a sense of connectivity to loved ones, of times past and also a sense of loss of ability. Participants also described the ways in which they coped and adapted to a life with anosmia and focused on positive aspects of life. These findings provide a rich qualitative account of the experience of anosmia. The findings point towards future research which could inform us about the lives of those who are anosmic and currently unaware and of those recently diagnosed, which will create a richer understanding of the experiences of anosmia.
Time-motion analysis in men’s breaking: A longitudinal study
Authors: Pérez-Portela Alberto , Prieto-Lage Iván , Argibay-González Juan Carlos , Reguera-López-de-la-Osa Xoana , Silva-Pinto Antonio José , Gutiérrez-Santiago Alfonso
Published: October 2023

Quantifying the effort of a sport confrontation by determining its temporal structure is of concern to the scientific community. In breaking this has not yet been sufficiently studied. The objectives of the study were to longitudinally analyze the temporal and sequential parameters of male breaking battles to determine the evolution of these parameters and to establish a model of temporal structure. All Red Bull BC One dancers from 2011 to 2021 (n = 152 dancers) participated. By using observational methodology, all battles were analyzed (n = 142). To obtain the results, we employed different analysis techniques: descriptive, normality tests, Student’s t-test or Mann-Whitney, one factor ANOVA or Kruskall-Wallis and effect size (Cohen’s d or Hedges’ g). The significance level established for the study was ρ ≤ 0.05. The results define the temporal and sequential structure of the battles. With these, breaking professionals will be able to develop precise and adequate training for these athletes. We conclude that approaches to dancing and battling have evolved. The effort that the athlete must exert is increasing and will therefore require better preparation to cope with the physical demands required for a sport that will be incorporated into the Olympics program in 2024.
Entrepreneurial action: A bibliometric study on the international scientific production
Authors: Ávila Milena Abreu , Andrade Daniela Meirelles , Silva Camila de Assis , Gonçalves Vinícius Batista
Published: October 2023

Objective: To analyze the international scientific production in the field of entrepreneurial action. Method: To investigate the theme of entrepreneurial action, the bibliometric method was used to fulfill the desired purposes. In the operationalization of the research, articles available in the Web of Science and Scopus databases were included. The database selection procedure was carried out by analyzing the documents using the software: My EndNote Web, Microsoft Excel and VOSviewer. Results: It was possible to identify the scarcity of compassionate research on the subject, in addition to the fact that little is known about the emergence of an entrepreneurial action and how, in fact, this research axis can contribute to studies on entrepreneurship. Theoretical contributions: It was identified that there are promising studies on the subject that made possible the exchange of the concept of entrepreneurial action and the different areas of knowledge through the construction of a synthesis matrix. Relevance/originality: The field of entrepreneurial action is still incipient and requires greater efforts towards a theoretical and empirical development, in order to establish and contribute to the construction of a very limited and defined conceptual structure about the phenomenon. Contributions to management: Studies on entrepreneurial action are directly related to case studies that report the emergence of entrepreneurial actions in organizations, which emphasizes the concentration of work in the areas of management and business.
The Boer and the Jackal: Satire and resistance in Khoi orature
Authors:   University of the Western Cape, Wittenberg Hermann
Published: October 2023

Bushman narratives have been the subject of a large volume of scholarly and popular studies, particularly publications that have engaged with the Bleek and Lloyd archive. Khoi story-telling has attracted much less attention. This paper looks a number of lesser known Khoi narratives, collected by Thomas Baines and Leonhard Schultze. Despite commonalities in the respective oral traditions, Khoi folklore appears more open to discursive modes of satire, mockery and ridicule, features which are not readily found in Bushman story telling. A number of Khoi narratives that feature the trickster figure of the jackal are presented and analysed as discursive engagements with historical realities and political forces that impinged on indigenous societies. It is argued that Khoi orature was able to mock and subvert settler dominance by making imaginative use of animal proxies such as the jackal. This capacity for satire in Khoi oral culture allowed it to resist colonial violence on a discursive level, a strategy that was much less pronounced in Bushman narration.
English as a Lingua Franca: Lessons for language and mobility
Authors:   National University of Singapore, Park Joseph Sung-Yul
Published: October 2023

Greater mobility of people in the globalising world foregrounds the inherent problems of an ideology of language as a bounded entity and the unequal relations of power that shape experiences of mobility. In this paper, we consider how these problems can be interrelated in research on language and mobility through a critical evaluation of current research on English as a lingua franca (ELF), particularly what we refer to as the ‘ELF research project’, exemplified by the work of Jenkins and Seidlhofer. TheELF project aims at a non-hegemonic alternative to English language teaching by identifying a core set of linguistic variables that can facilitate communication between speakers of different linguistic backgrounds. We provide a critical examination of the project by problematising its narrow conceptualisation of communication as information transfer and its inability to address the prejudices that speakers may still encounter because they speak the language ‘differently’. In our discussion, we argue that investigation of language in the context of mobility requires serious rethinking on the level of both theory and political stancetaking: a theory of language that does not take account of the fluid, dynamic, and practice-based nature of language will have considerable difficulty in proposing a cogent critique of social inequalities that permeate the lives of people on the move.
Ethnopharmacology, Antioxidant Activities, and Phytochemical Screening of Bioactive Extracts from the Seeds of Alangium Salvifolium, A Medicinal Plant
Authors: Tiwari Renu , Sharma Tripti
Published: October 2023

Phytochemical with antioxidant properties have great potential to combat plant and human diseases. This study aims to analyze the effects of different phytochemical constituents on different solvents on their extraction yield and also to determine the bioactive phytochemical and the amount of antioxidant activity of Alangium salvifolium seeds. For this study, the seeds of Alangium salvifolium were extracted, analyzed for phytochemical constituents, and evaluated for their antioxidant activity. Chemical analysis of phytochemical constituents was performed according to standard protocols. The antioxidant capacity of the plant extracts was measured using several in vitro techniques, including the DPPH radical scavenging assay and SOS activity. The plant extracts were subjected to phytochemical screening to determine their potential for antioxidant activity and the presence of bioactive components. The results of the current study show the ethanolic extract of Alangium salvifolium seeds showed remarkable antioxidant properties. Alangium salvifolium is a remarkable medicinal plant that contains a variety of bioactive secondary plant compounds and can be used to prevent several diseases. Recent research suggests that plant-derived antioxidants that scavenge free radicals may be useful in treating chronic diseases caused by free radicals.
Effect of Cladding Material and Date of Transplanting on Growth and Yield of Greenhouse Broccoli During Winter in High Altitude Ladakh, India
Authors: Dolma Tsering , Katiyar Anand K , Kumar Rohit , Chaurasia O P , Stobdan Tsering
Published: October 2023

Broccoli is a cool-season crop. The optimum temperature for initiation of flowering and head growth is 15-20°C. Due to subfreezing temperatures at night, the crop is not traditionally cultivated in winter in the high-altitude Ladakh region. We found that growing broccoli in a passive solar greenhouse in winter is feasible. The choice of greenhouse cladding material and the date of transplanting are important factors that need to be considered. The mean marketable head weight of the cv. Fiesta and KTS-1 in a passive solar trench greenhouse with polycarbonate cladding material transplanted on 8 September were 403±106 and 169±100 g, respectively. Delayed transplanting on 8 October did not produce any marketable head. Covering the greenhouse with a polyethylene sheet did not result in marketable heads on both transplanting dates. We anticipate our study to be a starting point for researchers and the farming community to optimize the greenhouse production of broccoli during freezing winter-months in high-altitude regions.
Recent Advancements in Prevalent Practices for Plant Cultivation by Hydroponics
Authors: Srivastava Utkarsha , Mathur Ashwani
Published: October 2023

Many plant-derived products are well known to possess therapeutic properties along with minimum side effectsand relatively competitive efficacies as compared to other chemical counterparts/analogs. Herbal drugs are therefore now widely accepted owing to their long-lasting impact. However, the role of cultivation conditions and associated biotic and abiotic parameters are paramount in affecting the yield of phytocompounds among cultivated plants. Moreover, with the increasing burden on cultivable land available for the production of cash crops, medicinal plants require alternative techniques of propagation for meeting commercial demands without adversely affecting their yield of phytocompounds and their therapeutic potential. Regulating the biotic and abiotic parameters using several methods of propagation (viz. vegetative and plant tissue culture) is instrumental in attaining the desired yield in the harvest. The major drawbacks of these techniques are lack of skilled labour and high monetary expense. Alternative techniques, such as hydroponics and aeroponics are pivotal to overcoming these disadvantages. The ‘Hydroponics’ technique involves plant cultivation in a soil-less nutrient medium. This method offers major advantages over the conventional techniques being more economical and independent of seasonal variations besides eliminating the influence of soil-microbe interactions on the development of plants. This technique is under continuous investigation and improvement with recent advances being made in the inter-disciplinary approaches for improving the technique by the addition of IoT and cloud computing along with other conventional techniques such as vertical farming forhydroponic systems and the development of hybrid models.
An education in educational technology
Authors: Goodyear Peter
Published: October 2023

“Educational technology” is a perfectly serviceable name for a field of research and development that is of practical importance and in which interesting intellectual challenges can be found. Stick with it.
Semantic micro-dynamics as a reflex of occurrence frequency: a semantic networks approach
Authors: Baumann Andreas , Hofmann Klaus , Marakasova Anna , Neidhardt Julia , Wissik Tanja
Published: October 2023

This article correlates fine-grained semantic variability and change with measures of occurrence frequency to investigate whether a word’s degree of semantic change is sensitive to how often it is used. We show that this sensitivity can be detected within a short time span (i.e., 20 years), basing our analysis on a large corpus of German allowing for a high temporal resolution (i.e., per month). We measure semantic variability and change with the help of local semantic networks, combining elements of deep learning methodology and graph theory. Our micro-scale analysis complements previous macro-scale studies from the field of natural language processing, corroborating the finding that high token frequency has a negative effect on the degree of semantic change in a lexical item. We relate this relationship to the role of exemplars for establishing form–function pairings between words and their habitual usage contexts.
Academic adjustment of international students studying in South Korea: the Global Korea Scholarship program perspective
Authors: Vanchinkhuu Narangerel , Shin Yousun
Published: October 2023

The study was to investigate the academic adjustment of international students studying in South Korea under the Global Korea Scholarship Program. Previous research has shown that academic adjustment is linked to the achievement and satisfaction of international students at higher education institutions. Two research questions shaped the current study: (1) examining the correlations between the variables included in the study and (2) identifying the significant variables that contributed to international students’ academic adjustment. The Multicultural Personality Survey and Academic Adjustment Survey were utilized as the primary instruments and were administered online over one and a half months. A total of 100 participants from diverse demographic backgrounds were involved in the data collection. Correlational analysis and regression analysis were employed to answer the two research questions. The results of the correlational analysis revealed that there were higher correlations observed between multicultural personality and GPA, preferred language and multicultural personality, as well as multicultural personality and the Academic Adjustment Survey. Additionally, the regression analysis indicated that Korean language proficiency and preferred language proficiency emerged as significant variables that impacted international students’ academic adjustment. The results provided further insights into the factors contributing to academic adjustment among international students in South Korea.
Audience Democracy 2.0: Re-Depersonalizing Politics in the Digital Age
Authors: Broučková Kristina , Kubíková Kateřina Labutta
Published: October 2023

This paper aims to explore the changes that representative democracy is experiencing as a result of the transformation of communication channels. In particular, it focuses on non-electoral representation in the form of movements that emerged throughout the 2010s and that were defined by a strong social media presence (e.g. Occupy Wall Street, Black Lives Matter, #MeToo, Yellow Vests). Despite not attempting to gain political power via elections, these movements, through online and offline activities, nonetheless managed to shape the realm of politics. The paper thus analyzes the movements’ inner representative dynamics and the ways they reshape representative democracy. It engages with a critical reading of Hanna Pitkin’s concept of symbolic representation and draws on Michael Saward’s framework of the representative claim to reevaluate Bernard Manin’s notion of “audience” democracy as today’s form of representative government. The argument is that, as digital development provides citizens with less demanding modes of political participation and platforms of representative claim-making, it enhances the sphere of opinion formation and the role of non-electoral representation. This sphere entails a tendency towards a re-depersonalization of politics, thus leading towards the transformation of “audience” democracy.
Orchestrating listening in EMI university lectures: how listening proficiency and motivation shape students’ use of metacognitive listening strategies
Authors: Zhou Sihan , Bai Barry , Hao Yuanyue
Published: October 2023

Recent research has called for cultivating strategic learners in globally expanding English medium instruction (EMI) university programs, so as to help them effectively orchestrate resources to handle the challenging task of learning subject knowledge through an L2. EMI studies exploring students’ strategies have thus far primarily categorized strategy types, with scant research investigating what key learner variables affect their strategic choices. This study focuses on students’ use of metacognitive listening strategies during EMI lectures, and explores how their strategic preferences differ across three groups of English listening proficiency and are influenced by motivational beliefs of self-efficacy, goal orientation, and task value. Results of ANOVA tests and Structural Equation Modeling (SEM) analysis of students’ questionnaire responses (N = 412) revealed significant variations in strategy types across different proficiency levels. Although students were found to be highly motivated by extrinsic goals and utility-based task values, these motivational beliefs failed to significantly predict any metacognitive strategy use. Both intrinsic learning goals and self-efficacy significantly predicted the use of directed attention, problem solving, and plan-evaluation strategies, highlighting the pedagogical needs to foster these motivational beliefs of students in EMI university programs to help them become strategic and independent listeners in academic lectures.
Generalized Lie n-derivations on arbitrary triangular algebras
Authors: Yuan He , Liu Zhuo
Published: October 2023

In this study, we consider generalized Lie

n

n

-derivations of an arbitrary triangular algebra

T

T

through the constructed triangular algebra

T

0

{T}_{0}

, where

T

0

{T}_{0}

is constructed using the notion of maximal left (right) ring of quotients.
Interfacing differently oriented biaxial van der Waals crystals for negative refraction
Authors: Liu Ruey-Tarng , Huang Chia-Chien
Published: October 2023

Negative refraction has a wide range of applications in diverse fields such as imaging, sensing, and waveguides and typically entails the fabrication of intricate metamaterials endowed with hyperbolic features. In contrast to artificially engineered hyperbolic materials, natural van der Waals (vdW) materials are more accessible owing to their inherent strong in-plane covalent bonding and weak interlayer interactions. However, most vdW materials manifest uniaxial crystal properties, which restrict their behavior solely to out-of-plane hyperbolicity. This characteristic poses a considerable challenge to their seamless integration via planar fabrication techniques, unless a suitable pattern is employed. Recent advances have identified natural biaxial α-MoO3 as a promising vdW material capable of exhibiting in-plane hyperbolicity. In this study, we performed numerical simulations demonstrating that negative refraction could be achieved by interfacing differently oriented α-MoO3 slabs coated with tunable graphene on a gold substrate. Our comprehensive analysis yielded three notable outcomes: negative refraction, simultaneous positive and negative refractions, and diffractionless propagation. These outcomes could be operated in a broad range of frequencies and achieved at all angles to offer a superior platform for the flexible manipulation of mid-infrared polaritons. Our findings provide valuable insights into the potential application of other two-dimensional vdW materials for advances in nanoscale super-resolution imaging, molecular sensing, and on-chip photonic integrated circuits.
Numerical simulation on the mixing behavior of double-wave screw under speed sinusoidal pulsating enhancement induced by differential drive
Authors: Liu Tian-lei , Du Yao-xue , He Xian-yun
Published: October 2023

A novel speed sinusoidal pulsating system is designed by applying differential drive, which is loaded on the plasticizing screw in an extruder or in an injection molding machine. With the CFD software ANSYS POLYFLOW 19.2, this paper builds simplified physical and mesh models for the double wave screw unit, carries out numerical simulation by using particle tracing manner, and finally analyses comparatively the mixing behavior of the wave screw mixing unit with and without sinusoidal pulsating field. It is found that the mixing screw unit with the superimposed excitation field takes on lower transportation efficiency and a descending melt pressure, while there are different reactions on the various pulsating amplitude and frequency for the max shear rate and mixing index. On the other hand, the introducing pulsating field can strengthen the shear field and gain a higher mixing efficiency. The results are of great importance and reference for improving the plasticizing performance and engineering application of the speed pulsating system.
7-Day National Institutes of Health Stroke Scale as a surrogate marker predicting ischemic stroke patients’ outcome following endovascular therapy
Authors: Lai Yuzheng , Jou Eric , Mofatteh Mohammad , Nguyen Thanh N. , Ho Jamie Sin Ying , Diana Francesco , Dmytriw Adam A. , He Jianfeng , Yan Wenshan , Chen Yiying , Yan Zile , Sun Hao , Yeo Leonard L. , Chen Yimin , Zhou Sijie
Published: October 2023

Background

Early neurological deterioration after endovascular thrombectomy (EVT) is associated with poor prognosis. National Institutes of Health Stroke Scale (NIHSS) score measured at 24 h after EVT may be a better outcome predictor than other methods that focus on changes in NIHSS. Nevertheless, clinical fluctuations in ischemic stroke patients during the immediate phase after symptoms onset are well recognized. Therefore, a delayed NIHSS evaluation may improve prognostic accuracy. We evaluate the 7-day NIHSS in predicting long-term patient outcomes after EVT.

Methods

This was a multi-center retrospective cohort study of 300 consecutive ischemic stroke patients with large vessel occlusion who underwent EVT at three-stroke centers in China from August 2018 to March 2022. NIHSS was recorded on admission, pre-EVT, 24 h, and 7 days after EVT.

Results

A total of 236 eligible patients were subdivided into two groups: 7-day NIHSS ≤6 and NIHSS >6 post-EVT. 88.29% achieved a favorable outcome (modified Rankin Scale 0–2) in the NIHSS ≤6 group compared to 15.20% in the NIHSS >6 group at 90 days, and an improved favorable outcome in the former group was observed after adjusting for potential confounding factors (adjusted odds ratio 39.7, 95% confidence interval, 17.5–89.7, p < 0.001).

Conclusion

The 7-day NIHSS score may be a reliable predictor of 90-day stroke patient outcome after EVT.
Der wirtschaftliche Griff in die Kiste
Authors: Breuling Georg , Kulessa Philipp , Schwartzen Lena , Kuhlenkötter Bernd
Published: October 2023

Die Produktion von technischen Systemen erfordert in Zeiten von Versorgungsengpässen, Personalmangel und fluktuierender Nachfrage ein hohes Maß an Anpassungsfähigkeit. Deshalb gilt es zu untersuchen, ob kollaborative Leichtbau-Roboter (MRK-Roboter) als Ausgleichsmöglichkeit wirtschaftlich sinnvoll für komplexe Handhabungsvorgänge, wie den Griff in die Kiste, eingesetzt werden können. Im Rahmen einer systematischen Eignungsanalyse konnte gezeigt werden, dass die erreichte Taktzeit von 7,84 Sekunden für die Vereinzelung und Montage einer Fugendüse industrielle Anforderungen von 3 bis 4 Sekunden bisher nicht erfüllen konnte. Weiterführende Optimierungen könnten diese Zeit jedoch auf ca. 4,60 Sekunden und somit annähernd auf das geforderte Intervall senken.
Wasserstoffeinsatz im Haushalts- und Gebäudesektor
Authors: Gramberg Till , Wendt Janek , Mais Franziska , Jelschow Vladimir , Gross Erwin , Sauer Alexander
Published: October 2023

Dieser Beitrag untersucht das Potenzial von grünem Wasserstoff im Haushalts- und Gebäudesektor für die Region Schwarzwald. Dazu wurde eine Bedarfsanalyse auf Basis bestehender Studien durchgeführt, die die potenzielle Nachfrage in drei verschiedenen Szenarien (Negativ, Trend und Positiv) ableitet. Durch eine qualitative und quantitative Datenerhebung wurden Hypothesen von Expert:innen den drei Szenarien zugeordnet und eine Roadmap mit Handlungsmaßnahmen für einen positiven Markthochlauf aufgestellt.
CONSIDERAÇÕES PUNGENTES AO MERCADO DE CRÉDITO DE CARBONO
Authors: Kruse Bárbara Cristina
Published: October 2023

Diante da crise ambiental vivenciada no tempo presente é que se reflete o escrito. O objetivo do artigo se dá na análise de como um instrumento que já existe, o mercado de crédito de carbono, pode vir a ser importante aliado na questão ambiental. A inquirição aqui posta, encontra fundamento na alta do preço do carbono, fazendo com que o ano de 2023 projete, ainda mais, o fortalecimento desse mercado. Utiliza-se, assim, a pesquisa exploratória e o método hipotético-dedutivo, baseado na revisão de literatura e em relatórios científicos para se chegar à conclusão. Destaca-se, ainda, o papel das ciências sociais e da interdisciplinaridade como práticas profissionais imprescindíveis nessa conjuntura ideária pós-pandemia do COVID-19. A importância do artigo, portanto, encontra-se embasada tanto nas áreas humanas quanto nas exatas, na medida em que a análise ambiental demanda múltiplos olhares profissionais, bem como põe em xeque a sobrevivência da espécie humana no Planeta Terra.
YAEL: Your Advanced Electrode Localizer
Authors: Wang Zhengjia , Magnotti John F. , Zhang Xiang , Beauchamp Michael S.
Published: October 2023

Intracranial electroencephalography (iEEG) provides a unique opportunity to record and stimulate neuronal populations in the human brain. A key step in neuroscience inference from iEEG is localizing the electrodes relative to individual subject anatomy and identified regions in brain atlases. We describe a new software tool, Your Advanced Electrode Localizer (YAEL), that provides an integrated solution for every step of the electrode localization process. YAEL is compatible with all common data formats to provide an easy-to-use, drop-in replacement for problematic existing workflows that require users to grapple with multiple programs and interfaces. YAEL's automatic extrapolation and interpolation functions speed localization, especially important in patients with many implanted stereotactic (sEEG) electrode shafts. The graphical user interface is presented in a web browser for broad compatibility and includes an interactive 3D viewer for easier localization of nearby sEEG contacts. After localization is complete, users may enter or import data into YAEL’s 3D viewer to create publication-ready visualizations of electrodes and brain anatomy, including identified brain areas from atlases; the response to experimental tasks measured with iEEG; and clinical measures such as epileptiform activity or the results of electrical stimulation mapping. YAEL is free and open source and does not depend on any commercial software. Installation instructions for Mac, Windows, and Linux are available athttps://yael.wiki.
Stabilizing Immature Dendritic Spines in the Auditory Cortex: A Key Mechanism for mTORC1-Mediated Enhancement of Long-Term Fear Memories
Authors: Concina Giulia , Gurgone Antonia , Boggio Elena M. , Raspanti Alessandra , Pizzo Riccardo , Morello Noemi , Castroflorio Enrico , Pizzorusso Tommaso , Sacchetti Benedetto , Giustetto Maurizio
Published: October 2023

Mammalian target of rapamycin (mTOR) pathway has emerged as a key molecular mechanism underlying memory processes. Although mTOR inhibition is known to block memory processes, it remains elusive whether and how an enhancement of mTOR signaling may improve memory processes. Here we found in male mice that the administration of VO-OHpic, an inhibitor of the phosphatase and tensin homolog (PTEN) that negatively modulates AKT-mTOR pathway, enhanced auditory fear memory for days and weeks, while it left short-term memory unchanged. Memory enhancement was associated with a long-lasting increase in immature-type dendritic spines of pyramidal neurons into the auditory cortex. The persistence of spine remodeling over time arose by the interplay between PTEN inhibition and memory processes, as VO-OHpic induced only a transient immature spine growth in the somatosensory cortex, a region not involved in long-term auditory memory. Both the potentiation of fear memories and increase in immature spines were hampered by rapamycin, a selective inhibitor of mTORC1. These data revealed that memory can be potentiated over time by the administration of a selective PTEN inhibitor. In addition to disclosing new information on the cellular mechanisms underlying long-term memory maintenance, our study provides new insights on the molecular processes that aid enhancing memories over time.

SIGNIFICANCE STATEMENTThe neuronal mechanisms that may help improve the maintenance of long-term memories are still elusive. The inhibition of mammalian-target of rapamycin (mTOR) signaling shows that this pathway plays a crucial role in synaptic plasticity and memory formation. However, whether its activation may strengthen long-term memory storage is unclear. We assessed the consequences of positive modulation of AKT-mTOR pathway obtained by VO-OHpic administration, a phosphatase and tensin homolog inhibitor, on memory retention and underlying synaptic modifications. We found that mTOR activation greatly enhanced memory maintenance for weeks by producing a long-lasting increase of immature-type dendritic spines in pyramidal neurons of the auditory cortex. These results offer new insights on the cellular and molecular mechanisms that can aid enhancing memories over time.
Menstrual health during COVID-19: How water, sanitation, and hygiene strategies can improve menstrual health and hygiene and foster gender equality
Authors: Ingraham Rachel Fisher , Joe Karen
Published: October 2023

Despite the fact that over 800 million women, girls, transgender, and gender nonbinary persons menstruate, menstrual health and hygiene (MHH) remains a taboo and under-resourced public health subject. Water, sanitation, and hygiene (WASH) insecurity, an issue made worse by the COVID-19 pandemic, plays a significant role in menstruators’ abilities to safely manage their periods. COVID-19 has further revealed how a continued lack of access to WASH resources hinders an individuals’ means to address their menstrual health with dignity. The impacts of COVID-19 have laid bare the many challenges associated with menstruation, intensifying existing inequalities for women, girls, and other menstruators. Mobility limitations and quarantining have created complex obstacles for menstruators while lockdown protocols, border closures, and panic buying have impacted the sanitary pad supply chain. Community and school closures have removed many of the routine ways in which menstruators access sanitary products. Our article seeks to understand how the pandemic and existing WASH systems exacerbated the ongoing challenges associated with MHH, highlighting opportunities for future crisis planning to advance MHH infrastructure, resources, and stigma reduction. A landscape analysis was used to understand how the pandemic affected those who menstruate. Academic, peer-reviewed literature as well as gray literature informed the authors’ understanding of the dynamic nature of COVID-19 and WASH infrastructure on menstruators. From these insights, the authors were able to identify emerging themes and trends that they have highlighted in this article. Water and sanitation programs have the power to improve gender equality and equity, health, and education by investing in menstrual hygiene infrastructure, awareness creation, and stigma reduction. The diversion of resources, and in particular WASH resources, toward pandemic-related hygiene supplies and mobility restrictions, however, have exposed menstruators to sexual exploitation and physical and mental strain. It is critical to understand and address the pandemic’s impacts on menstruators, drawing lessons from and creating opportunities to systematically advance MHH, thereby elevating gender equality.
The US-China Trade War Phenomenon (2018-2020) In Economic Diplomacy Perspective
Authors: Kholid Muhammad
Published: October 2023

The US-China trade war in 2018-2020 has attracted the attention of many observers and researchers to investigate the driving forces that cause the clash between the two great power countries. Most of them place this phenomenon in the prism of realism by using Thucydides’ trap as a framework. Several studies analyze it within the framework of economics and political economy perspectives. This article tries to fill the gap in the explanation of the US-China trade war by using the economic diplomacy framework. Based on a qualitative method, the author argues that the United States under the leadership of Donald Trump uses tariff bargaining as a diplomatic tool to protect and maintain the supremacy of the United States' innovation and technology against China.
The Influence of Social Capital and Fear of Covid-19 on the Participation of Coastal Communities During the Pandemic in Palu City
Authors: Anriani Haslinda Badji , Samad Muhammad Ahsan , Alfian Muhammad
Published: October 2023

The advent of the Covid-19 pandemic has engendered multifaceted repercussions encompassing the economic, social, and psychological dimensions of coastal towns. In response, a proactive and concerted effort is imperative to cultivate a resilient society capable of withstanding the adversities posed by the Covid-19 pandemic. This necessitates the systematic integration of coastal communities through a scientific approach. This research elucidates the intricate interplay between social capital, apprehensions regarding Covid-19, and their combined influence on the determinants of community engagement. By means of an online survey, a cohort of 303 urban communities residing in the coastal regions of Palu-Donggala actively partook in this investigation. The outcomes of this study underscore the discernible impacts of both social capital and Covid-19-related concerns on the level of participation exhibited by coastal communities. The empirical insights gleaned from this study are poised to serve as a foundational resource for diverse stakeholders engaged in formulating interventions and policies aimed at augmenting community involvement within coastal enclaves. It is essential to acknowledge that further research endeavors are warranted to comprehensively discern the array of predictors underpinning and the far-reaching consequences of participatory behavior within coastal communities.
The Depoliticization of Ecology: Discourse Analysis of Land Conflict in Punclut, North Bandung Region
Authors: Sulaeman Kirana Mahdiah , Nurdini Fadiyah Matni , Mustofa Mustabsyirotul Ummah
Published: October 2023

This study discusses the narrative and discourse in the conflict over land use in Punclut, Pagerwangi, North Bandung Region. The local community has managed the water catchment area of the North Bandung area for several decades before coming into conflict with the property company PT DAM which obtained a building permit from the government. Departing from Garet Hardin's Tragedy of the Commons, this research explores the causes of natural degradation in Punclut through a discourse on natural resource control by two warring parties: residents and the government. A qualitative approach with discourse analysis is used to answer research questions using data from interviews, mass media, journal articles, and official documents. The findings of this study are that Hardin's solution to the destruction of natural resources needs to be revised to answer the conditions in Punclut, where there is a local community with sociocultural rules and rationality to manage natural resources with ecological awareness. This community offers an alternative political discourse regarding environmental management: "depoliticization of ecology" and participatory conservation. However, the government and companies' discourse on welfare and economic progress always dominates the discourse in the decision-making process.
Does Money Triumph over Identity? a Survey Findings from the Local Levels
Authors: Saputra Andhik Beni , Setiawan Azhari
Published: October 2023

In this article, we try to analyze which factors emerged as the strongest determinants of voters’ behavior in a new democratic country dominated by the web of patronage and clientelistic exchanges. We examine two main variables in this study, vote buying and identity politics. Previous studies on electoral clientelism in Indonesia are mostly centered on its causes and mechanisms as an electoral strategy to garner electoral votes during an election. The socio-political contexts that follow the electoral dynamics are less explained. Initially, we assume that the intensive mobilization of identity politics that made the 2019 Indonesia election more explosive would decrease since voters would also solidify their voting preference into identity lines. However, through a post-election survey at the local level by selecting four districts (N=503), we find that vote buying emerges as a more robust variable in driving voters’ behavior rather than identity politics. Moreover, regional differentiation – land and coastal areas – also matter in this study where voters in the coastal regions are more likely to accept material inducements from candidates. Finally, our findings add many tasks for Indonesian democracy since clientelistic exchanges work as a more effective instrument for affecting voters' decision-making in elections rather than programmatic politics.
FLNA expression modulates pathological markers of pituitary neuroendocrine tumours
Authors: Toledo Jonathan , Perez Pablo Aníbal , Zanetti Mical , Díaz-Torga Graciela , Mukdsi Jorge Humberto , Gutierrez Silvina
Published: October 2023

Due to the current limited knowledge about the role of filamin A (FLNA) in pituitary tumour progression, we aimed to analyse FLNA expression levels and its impact on aggressive markers of pituitary neuroendocrine tumours (PitNETs), using an integrative approach of in vivo and in vitro models and human samples. An increase in the expression levels of FLNA was observed in the advanced tumoural stages of the hyperplastic adenomatous pituitary model, concomitant with a decrease in cell proliferation and with a modification in the subcellular localisation of this protein. Similarly, overexpression of FLNA in the somatolactotropic GH3 cell line induced a decrease in the cell proliferation, promoted a migratory phenotype, increased invasion activity, and decreased the prolactin secretion. Cyclin D1 (CCND1) and cyclin-dependent kinase 4 (CDK4) expression increased in both models in correlation with the increase observed in FLNA levels. When human tissues were analysed a significant increase of FLNA was observed in PitNETs compared to normal pituitary gland, with heterogeneous intracellular localisation. Higher levels of FLNA expression were observed in tumours with invasive characteristics. These results underline the crucial roles of FLNA as a modulator of pathological markers and as a potential prognostic marker in pituitary tumours.
Érase una vez un cuento… ¡musical! Criterios para su uso en la iniciación a la música
Authors: Álvarez Cortizo Laura , Casals Ibáñez Albert , González Martín Cristina
Published: October 2023

El cuento musical se dibuja como una herramienta muy útil en contextos de iniciación musical, pero ¿se aprovecha el potencial educativo y motivador de estos cuentos en la enseñanza especializada de la música? La iniciación musical suele llevarse a cabo en el ámbito de las enseñanzas no regladas, donde encontramos un déficit de investigaciones y experiencias publicadas que nos permiten conocer los recursos más utilizados, entre ellos el cuento musical.

La investigación que se presenta busca extraer algunas claves para la inclusión del cuento musical en el proceso de enseñanza-aprendizaje de la música. Para ello, se realizaron entrevistas y grupos de discusión con expertos, analizándose sus aportaciones en relación a una definición de cuento musical y a las directrices para la elaboración y el uso de éstos en el ámbito de la iniciación a la música. Los resultados permiten conocer cuáles son los elementos que deben subyacer en una propuesta didáctica que, partiendo de un cuento musical que funcione como hilo conductor, implique un proceso de enseñanza-aprendizaje significativo de la música.
Basic course of mathematics created by overlapping methodology of topics
Authors: Burgis Bronislovas
Published: October 2023

How to decrease the redundancy in the textbooks of mathematics? How to improve the math curricula? Overlapping of topics is the source for improvement. Proposals of this article are based on the experience acquired in the process of writing a book of math examples for high school and university students.