bluuebunny/crossref_metadata_2025 huggingface dataset:
Prognostic Significance of [18F]-Misonidazole Positron Emission Tomography–Detected Tumor Hypoxia in Patients With Advanced Head and Neck Cancer Randomly Assigned to Chemoradiation With or Without Tirapazamine: A Substudy of Trans-Tasman Radiation Oncology Group Study 98.02
Authors: Rischin Danny , Hicks Rodney J. , Fisher Richard , Binns David , Corry June , Porceddu Sandro , Peters Lester J.
Published: April 2006

Purpose

To determine the association between tumor hypoxia, treatment regimen, and locoregional failure (LRF) in patients with stage III or IV squamous cell carcinoma of the head and neck randomly assigned to radiotherapy (70 Gy in 35 fractions over 7 weeks) plus either tirapazamine and cisplatin in weeks 1, 4, and 7 and tirapazamine alone in weeks 2 and 3 (TPZ/CIS) or cisplatin and infusional fluorouracil during weeks 6 and 7 (chemoboost).

Patients and Methods

Forty-five patients were enrolled onto a hypoxic imaging substudy of a larger randomized trial. Pretreatment and midtreatment [18F]-fluoromisonidazole positron emission tomography scans (FMISO-PET) were performed 2 hours after tracer administration, with qualitative scoring of uptake in both primary tumors and nodes.

Results

Thirty-two patients (71%) had detectable hypoxia in either or both primary and nodal disease. In patients who received chemoboost, one of 10 patients without hypoxia had LRF compared with eight of 13 patients with hypoxia; the risk of LRF was significantly higher in hypoxic patients (exact log-rank, P = .038; hazard ratio [HR] = 7.1). By contrast, in patients who received the TPZ/CIS regimen, only one of 19 patients with hypoxic tumors had LRF; risk of LRF was significantly higher in chemoboost patients (P = .001; HR = 15). Similarly, looking at the primary site alone, in patients with hypoxic primaries, zero of eight patients treated with TPZ/CIS experienced failure locally compared with six of nine patients treated with chemoboost (P = .011; HR = 0).

Conclusion

Hypoxia on FMISO-PET imaging, in patients receiving a nontirapazamine-containing chemoradiotherapy regimen, is associated with a high risk of LRF. Our data provide the first clinical evidence to support the experimental observation that tirapazamine acts by specifically targeting hypoxic tumor cells.
Chemotherapy Regimen Predicts Steatohepatitis and an Increase in 90-Day Mortality After Surgery for Hepatic Colorectal Metastases
Authors: Vauthey Jean-Nicolas , Pawlik Timothy M. , Ribero Dario , Wu Tsung-Teh , Zorzi Daria , Hoff Paulo M. , Xiong Henry Q. , Eng Cathy , Lauwers Gregory Y. , Mino-Kenudson Mari , Risio Mauro , Muratore Andrea , Capussotti Lorenzo , Curley Steven A. , Abdalla Eddie K.
Published: April 2006

Purpose

Chemotherapy before resection of hepatic colorectal metastases (CRM) may cause hepatic injury and affect postoperative outcome.

Patients and Methods

Four hundred six patients underwent hepatic resection of CRM between 1992 and 2005. Pathologic review of the nontumorous liver was performed using established criteria for steatosis, steatohepatitis, and sinusoidal injury. The effect of chemotherapy and liver injury on perioperative outcome was analyzed.

Results

One hundred fifty-eight patients (38.9%) received no preoperative chemotherapy, whereas 248 patients (61.1%) did. The median duration of chemotherapy was 16 weeks (range, 2 to 70 weeks). Chemotherapy consisted of fluoropyrimidine-based regimens (fluorouracil [FU] alone, 15.5%; irinotecan plus FU, 23.1%; and oxaliplatin plus FU, 19.5%) and other therapy (3.0%). On pathologic analysis, 36 patients (8.9%) had steatosis, 34 (8.4%) had steatohepatitis, and 22 (5.4%) had sinusoidal dilation. Oxaliplatin was associated with sinusoidal dilation compared with no chemotherapy (18.9% v 1.9%, respectively; P < .001; odds ratio [OR] = 8.3; 95% CI, 2.9 to 23.6). In contrast, irinotecan was associated with steatohepatitis compared with no chemotherapy (20.2% v 4.4%, respectively; P < .001; OR = 5.4; 95% CI, 2.2 to 13.5). Patients with steatohepatitis had an increased 90-day mortality compared with patients who did not have steatohepatitis (14.7% v 1.6%, respectively; P = .001; OR = 10.5; 95% CI, 2.0 to 36.4).

Conclusion

Steatohepatitis is associated with an increased 90-day mortality after hepatic surgery. In patients with hepatic CRM, the chemotherapy regimen should be carefully considered because the risk of hepatotoxicity is significant.
Domain‐Specific Principles Affect Learning and Transfer in Children
Authors: Brown Ann L.
Published: April 2006

In this paper I discuss the curious lack of contact between developmental psychologists studying the principles of early learning and those concentrating an later learning in children, where predispositions to learn certain types of concepts are less readily discussed. Instead, there is tacit agreement that learning and transfer mechanisms are content‐independent and age‐dependent. I argue here that one cannot study learning and transfer in a vacuum and that children's ability to learn is intimately dependent on what they are required to learn and the context in which they must learn it. Specifically, I argue that children learn and transfer readily, even in traditional laboratory settings, if they are required to extend their knowledge about causal mechanisms that they already understand. This point is illustrated in a series of studies with children from 1 to 3 years of age learning about simple mechanisms of physical causality (pushing‐pulling, wetting, cutting, etc.). In addition, I document children's difficulty learning about causally impossible events, such as pulling with strings that do not appear to make contact with the object they are pulling. Even young children transfer on the basis of deep structural principles rather than perceptual features when they have access to the requisite domain‐specific knowledge. I argue that a search for causal explanations is the basis of broad understanding, of wide patterns of generalization, and of flexible transfer and creative inferential projections—in sum, the essential elements of meaningful learning.
Laboratory Replication of Scientific Discovery Processes
Authors: Qin Yulin , Simon Herbert A.
Published: April 2006

Fourteen subjects were tape‐recorded while they undertook to find a law to summarize numerical data they were given. The source of the data was not identified, nor were the variables labeled semantically. Unknown to the subjects, the data were measurements of the distances of the planets from the sun and the periods of their revolutions about it—equivalent to the data used by Johannes Kepler to discover his third law of planetary motion.

Four of the 14 subjects discovered the same law as Kepler did (the period varies as the 3/2 power of the distance), and a fifth came very close to the answer. The subiects' protocols provide a detailed picture of the problem‐solving searches they engaged in, which were mainly, but not exclusively, in the space of possible functions for fitting the data, and provide explanations as to why some succeeded and the others failed.

The search heuristics used by the subjects are similar to those embodied in the BACON program, computer simulation of certain scientific discovery processes. The experiment demonstrates the feasibility of examining some of the processes of scientific discovery by recreating, in the laboratory, discovery situations of substantial historical relevance. It demonstrates also, that under conditions rather similar to those of the original discoverer, a law can be rediscovered by persons of ordinary intelligence (i.e., the intelligence needed for academic success in a good university). The data for the successful subjects reveal no “creative” processes in this kind of a discovery situation different from those that are regularly observed in all kinds of problem‐solving settings.
Postnatal Remodeling of Dendritic Structure and Spine Density in Gonadotropin-Releasing Hormone Neurons
Authors: Cottrell Elizabeth C. , Campbell Rebecca E. , Han Seong-Kyu , Herbison Allan E.
Published: April 2006

The GnRH neurons represent the output cells of the neuronal network controlling gonadal function. Their activation initiates the onset of puberty, but the underlying mechanisms remain unclear. Using a GnRH-green fluorescent protein mouse model, we have been able to fill individual GnRH neurons with biocytin in the acute brain slice preparation to examine their morphological characteristics across puberty. GnRH neurons in prepubertal male mice [postnatal d 10–15 (PND10–15)] exhibited half as many dendritic and somal spines as adult male mice (>PND60; P < 0.05) but, surprisingly, a much more complex dendritic tree with 5-fold greater branch points (P < 0.05). Experiments examining somal and proximal dendritic spine numbers in vivo, in perfusion-fixed tissue from GnRH-green fluorescent protein mice, revealed the same pattern of approximately twice as many spines on adult GnRH neurons compared with PND10 male mice (P < 0.01). In contrast to the spine density alterations, reflecting changing excitatory input, confocal immunofluorescence studies revealed no differences in the numbers of vesicular γ-aminobutyric acid transporter-immunoreactive elements adjacent to GnRH soma or proximal dendrites in prepubertal and adult male mice. Experiments evaluating dendritic tree structure in vivo (PND3, -10, and -35 and adult) revealed that GnRH neurons located in the rostral preoptic area, but not the medial septum, exhibited a more complex branching pattern at PND10, but that this was adult-like by PND35. These studies demonstrate unexpected dendritic tree remodeling in the GnRH neurons and provide evidence for an increase in direct excitatory inputs to GnRH neurons across the time of puberty.
Identification of a Basic Helix-Loop-Helix Transcription Factor Expressed in Mammary Gland Alveolar Cells and Required for Maintenance of the Differentiated State
Authors: Zhao Yan , Johansson Carina , Tran Thai , Bettencourt Ryan , Itahana Yoko , Desprez Pierre-Yves , Konieczny Stephen F.
Published: April 2006

The development of mammary glands relies on complicated signaling pathways that control cell proliferation, differentiation, and apoptotic events through transcriptional regulatory circuits. A key family of transcription factors used in mammary gland development is the helix-loop-helix/basic helix-loop-helix (HLH/bHLH) protein family. In this study, we identify Mist1 as a tissue-restricted Class II bHLH transcription factor expressed in lactating mammary glands. Mouse and human mammary glands accumulated Mist1 protein exclusively in secretory alveolar cells, and Mist1 transcripts were differentially expressed in mouse SCp2 cells induced to differentiate by addition of lactogenic hormones. Mist1 null (Mist1KO) lactating mammary glands were defective in normal lobuloalveolar organization, exhibiting shedding of cells into the alveolus lumen and premature activation of the signal transducer and activator of transcription 3 signaling pathway. These cells also failed to maintain expression of the gap junction proteins connexin26 and connexin32, leading to the loss of gap junctions. Our findings suggest that loss of Mist1 impairs the maintenance of the fully differentiated alveolar state and, for the first time, places Mist1 within the hierarchy of known HLH/bHLH proteins that control mammary epithelial cell development.
Nature of Functional Estrogen Receptors at the Plasma Membrane
Authors: Pedram Ali , Razandi Mahnaz , Levin Ellis R.
Published: April 2006

Although rapid signaling by estrogen at the plasma membrane is established, it is controversial as to the nature of the receptor protein. Estrogen may bind membrane proteins comparable to classical nuclear estrogen receptors (ERs), but some studies identify nonclassical receptors, such as G protein-coupled receptor (GPR)30. We took several approaches to define membrane-localized estrogen-binding proteins. In endothelial cells (ECs) from ERα/ERβ combined-deleted mice, estradiol (E2) failed to specifically bind, and did not activate cAMP, ERK, or phosphatidyinositol 3-kinase or stimulate DNA synthesis. This is in contrast to wild-type ECs, indicating the lack of any functional estrogen-binding proteins in ERα/ERβ combined-deleted ECs. To directly determine the identity of membrane and nuclear-localized ER, we isolated subcellular receptor pools from MCF7 cells. Putative ER proteins were trypsin digested and subjected to tandem array mass spectrometry. The output analysis identified membrane and nuclear E2-binding proteins as classical human ERα. We also determined whether GPR30 plays any role in E2 rapid actions. MCF7 (ER and GPR30 positive) and SKBR-3 (ER negative, GPR30 positive) cells were incubated with E2. Only MCF7 responded with significantly increased signaling. In MCF7, the response to E2 was not different in cells transfected with small interfering RNA to green fluorescent protein or GPR30. In contrast, interfering RNA to ERα or ER inhibition prevented rapid signaling and resulting biology in MCF7. In breast cancer and ECs, nuclear and membrane ERs are the same proteins. Furthermore, classical ERs mediate rapid signals induced by E2 in these cells.
Catalytic Properties of Framework Iron in MFI-Type Ferrisilicate for the Oxidative Dehydrogenation of n-Butane
Authors: Uddin Md Azhar , Komatsu Takayuki , Yashima Tatsuaki
Published: April 2006

The catalytic properties of MFI-type ferrisilicate for the oxidative dehydrogenation of n-butane were compared with those of iron-oxide impregnated silicalite (FeOx/Sil) and Fe3+ exchanged ZSM-5 (FeZSM-5). The framework Fe3+ in ferrisilicate showed much higher dehydrogenation selectivity than Fe3+ in FeOX/Sil and FeZSM-5.
Synthesis of Δ3-1,3,4-Telluradiazolines, a Novel Tellurium-Containing Heterocycle
Authors: Okazaki Renji , Minoura Mao , Kawashima Takayuki
Published: April 2006

Reaction of sterically hindered hydrazones with tellurium dichloride in the presence of triethylamine in benzene afforded Δ3-1,3,4-telluradiazolines, a novel heterocycle, probably via 1,3-dipolar cycloaddition of telluroketones with diazo compounds, both generated in situ.
Synthesis and Electrochemical Properties of Dinuclear Manganese(II) Complexes with Octadentate Schiff-base Macrocycles. Fine Tuning of the Redox Behavior
Authors: Ikawa Yoshiya , Nagata Toshi , Maruyama Kazuhiro
Published: April 2006

A series of dinuclear manganese(II) complexes [R1-LMn2(R2CO2)]ClO4 were synthesized and X-ray crystal structure analysis of [CH3-LMn2(CH3CO2)]ClO4 (1) was performed. Two manganese ions of 1 were six-coordinate with highly deformed octahedral structure. Electrochemical measurements of these complexes revealed that both the substituents of the phenol ring and those on the ligating acetate effectively control the redox properties of the Mn(II) center.
A Convenient Synthesis of Carboxanilides from Silyl Carboxylates and Weakly Nucleophilic Anilines Using p-Trifluoromethylbenzoic Anhydride and a Catalytic Amount of Active Titanium(IV) Salt
Authors: Miyashita Mitsutomo , Shiina Isamu , Mukaiyama Teruaki
Published: April 2006

Various carboxanilides are prepared in excellent yields from nearly equimolar amounts of silyl carboxylates and the corresponding weakly nucleophilic anilines under mild conditions by using p-trifluoromethylbenzoic anhydride and a catalytic amount of active titanium(IV) salt.
Radical Cation Salts of 2,3,8,9-Tetrahydro-1,4,7,10-tetrathiachrysene
Authors: Tani Hiroyuki , Nii Katsunori , Masumoto Kazunori , Azuma Nagao , Ono Noboru
Published: April 2006

A novel 2,3,8,9-tetrahydro-1,4,7,10-tetrathiachrysene (7) was conveniently prepared by dithioacetalization of 1,5-decalinedione with 1,2-ethanedithiol followed by ring expansion and aromatization on treatment with tellurium tetrachloride. Electrocrystallization by anodic oxidation of 7 in the presence of suitable electrolytes gave the radical cation salts, (7)2ClO4 or (7)2BF4 with a considerable high electrical conductivity (0.4–12 Scm−1) and good thermal stability. Single crystal X-ray analyses revealed a segregated stack structure for 7 and anions in these salts.
Double Sulfur Trans Influence in the Dithiolato Complex: trans(S)-[Co(aet)2(en)]ClO4 (act = 2-Aminoethanethiolate)
Authors: Yonemura Toshiaki , Okamoto Ken-ichi , Ama Tomoharu , Kawaguchi Hiroshi , Yasui Takaji
Published: April 2006

The title aliphatic thiolato complex, whose trans positions were occupied by two sulfur atoms, was newly prepared and its crystal structure was determined by the X-ray diffraction study. The Co-S bond distances in that complex are longer than the ordinary one. Reaction of the complex at 50 °C in water gave cis(S)-[Co(aet)2(en)]+ and trinuclear complex, [Co{Co(aet)3}2]3+.
Lewis Acid-Induced Hetero Diels-Alder Reaction of Conjugated Carbodiimides
Authors: Saito Takao , Ohkubo Takahiro , Maruyama Katsuhiro , Kuboki Hideki , Motoki Shinichi
Published: April 2006

In the presence of a Lewis acid conjugated carbodiimides smoothly react as 2-azadienes with various dienophiles such as acetylenic compound, enamine, vinyl ether, and aldehyde under mild reaction conditions to give good yields of nitrogen heterocycles as cycloadducts.
Intrinsic Structures of [CuCl4]2− and [CuBr4]2− Anions by Ab Initio Density Functional Calculations
Authors: Waizumi Kenji , Masuda Hideki , Einaga Hisahiko , Fukushima Nobuhiro
Published: April 2006

The intrinsic structures of [CuCl4]2− and [CuBr4]2− have been investigated by ab initio density functional method and determined to be D2d symmetry with the flattening X-Cu-X angles of 138° and 130° for the case of X = Cl and Br, respectively, and the Cu-X distances of 228 pm and 241 pm, respectively, which are good agreement with the experimental data.
Stereochemistry of Bicyclohumulenediol and Equilibrium between Two Humulene Epoxides II and III. Novel Interconversion of Two Cycloundecatriene Epoxides through Transannular Bond Formation
Authors: Hayano Kiyoharu , Shirahama Haruhisa
Published: April 2006

The structure of bicyclohumulenediol, which was obtained from humulene epoxide II (1) and/or III (2) by treatment with aqueous solution at pH 4 by Yang and Deinzer, was revised and a new scheme for the equilibrium process among 1, 2 and tricyclohumulenediol was presented.
Preparation and Molecular Orientation of a Regular Cast Film of Fluorocarbon Bilayers
Authors: Kuwahara Hiroaki , Ishikawa Yuichi , Kunitake Toyoki
Published: April 2006

A multilayered cast film was prepared from a dispersion of a fluorocarbon/hydrocarbon amphiphile in chlorocyclohexane. Its solid-solid phase transition involved unwinding of the fluorcarbon helix and improved chain alignment.
Novel Syntheses of 1, 2-Diarylacetylenes and α-Silylalcohols from Acylsilanes Mediated by Ytterbium Metal
Authors: Taniguchi Yuki , Fujii Nobuto , Makioka Yoshikazu , Takaki Ken , Fujiwara Yuzo
Published: April 2006

Aromatic acylsilanes such as benzoyltrimethylsilane react with ytterbium metal to give symmetrical 1,2-diarylacetylenes in good yields. Aliphatic acylsilanes are reduced with lanthanoid reagents such as Yb metal and SmI2 to afford α-silylalcohols.
Synthesis and Structure of Polysilabridged Bisallenes
Authors: Hojo Fusao , Shimizu Toshio , Ando Wataru
Published: April 2006

Tetrasilacyclodeca-1,2,6,7-tetraenes (3a:dl) and (3b:meso) are synthesized by the reaction of the Ph2C3 dianion with tetramethyldichlorodisilane. X-Ray crystallographic analyses of 3a and 3b show allenic sp carbons to be bent by 4° (average). The optimized structures of disilacycloocta-1,2,5,6-tetraenes estimated by semiempirical PM3 calculations are also reported.
Lipid Anchored Myoglobin 2. Effect of the Anchor Structure on Membrane Binding
Authors: Hamachi Itaru , Higuchi Sho-ichi , Nakamura Kentaro , Fujimura Hidetoshi , Kunitake Toyoki
Published: April 2006

Protoheme derivatives with different anchor structures were successfull incorporated into apomyoglobin. A longer oxyethylene unit in the anchor was required for efficient, anisotropic binding of the reconstituted myoglobin onto the DPPC bilayer membrane.
New Photochemically Labile Protecting Group for Phosphates
Authors: Furuta Toshiaki , Torigai Hiromi , Osawa Tomoko , Iwamura Michiko
Published: April 2006

New photochemically labile phosphate protecting group was developed. These phosphate esters have high molar extinction coefficient (ε340 = 34500 dm3 mol−1 cm−1) and rapidly release parent phosphates upon irradiation ( >300 nm) with high quantum efficiency for disappearance (φdis = 0.22 at 340 nm).
Influence of Large Magnetic Fields on the Dynamic Behavior of a Radical Pair Produced by Photoreduction of Benzophenone in a Micellar Solution
Authors: Sakaguchi Yoshio , Hayashi Hisaharu
Published: April 2006

The photochemical reaction of benzophenone in a micellar sodium dodecylsulfate solution was investigated under magnetic fields of 0–10 T. The decrease of decay rate of the ketyl radical and the increase of the yield of the escaped radical were saturated around 2 T. The contribution of the Δg mechanism was not observed below 10 T since the Δg value is very small for this system.
Stereocontrolled Synthesis of β-d-2′-Deoxyribonucleosides by Intramolecular Glycosylation
Authors: Sujino Keiko , Sugimura Hideyuki
Published: April 2006

Intramolecular glycosylation of phenyl 2-deoxy-5-O-(2-pyridyl)- and 2-deoxy-5-O-(4-methoxy-2-pynmidyl)-1-thio-d-ribofuranoside by activation with dimethyl(methylthio)sulfonium tetrafluoroborate followed by hydrolysis gave the corresponding β-2′-deoxyribonucleoside derivatives in good yields.
1H and 19F NMR Studies on Phase Transitions and Ionic Motions in Choline Tetrafluoroborate
Authors: Ishida Hiroyuki , Asaji Tetsuo , Furukawa Yoshihiro , Ikeda Ryuichi
Published: April 2006

Three solid phases of (CH3)3NCH2CH2OHBF4 were found between 160 K and the melting point (485 K) by DTA, DSC, and 1H and 19F NMR measurements; the phases designated as I, II, and III are stable above 402 K, between 402 and 268 K, and below 268 K, respectively. In Phase II, the cations and anions were found to perform rapid self-diffusion as well as isotropic reorientation. At the transition point (Phase II → I), “quenching” of the cationic self-diffusion was observed.
Preparation of α,β-Unsaturated Methyl Ketones from Diketene Using Bis(tributyltin) Oxide
Authors: Shibata Ikuya , Nishio Masahiro , Baba Akio , Matsuda Haruo
Published: April 2006

Novel type tin enolate is easily formed by the regioselective ring cleavage of diketene with Bis(tributyltin) oxide [(n-Bu3Sn)2O]. The enolate caused carbon-carbon bond formation with aldehydes. As a result, α,β-unsaturated methyl ketones were obtained in good yields, accompanied by decarboxylation.
Electrochemical Confirmation of Disproportionate of μ-Oxo-bis[(N,N′-ethylenebis(salicylideneaminato))vanadium(IV)] Tetrafluoroborate
Authors: Yamamoto Kimihisa , Oyaizu Kenichi , Iwasaki Naoki , Tsuchida Eishun
Published: April 2006

μ-Oxo-bis[(N,N′-ethylenebis(salicylideneaminato))vanadium(IV)] tetrafluoroborate is prepared from (N,N′-ethylenebis(salicylideneaminato)) oxovanadium(IV) (VO(salen)) through an electrophilic reaction by triphenylmethyl tetrafluoroborate (Ph3CBF4) in dichloromethane. The voltammetric analysis of the binuclear complex in dichloromethane revealed a one-step two-electron transfer at 0.58 V (vs Ag/AgCl) based on the disproportionation (2VIVOVIVIIIOVIV + VIVOVV).V
Synthesis of Silicon Substituted Cyclopropylmethyl Alcohols in Optically Active Form via Asymmetric Simmons-Smith Reaction of γ-Silicon Substituted Allylic Alcohols
Authors: Ukaji Yutaka , Sada Kazunori , Inomata Katsuhiko
Published: April 2006

Optically active silicon substituted cyclopropylmethyl alcohols were synthesized through asymmetric Simmons-Smith reaction; that is, the reaction of γ-silicon substituted allylic alcohols with diethylzinc and diiodomethane utilizing (+)-diethyl tartrate as a chiral auxiliary was found to afford the corresponding silicon substituted cyclopropylmethyl alcohols with high stereoselectivity up to 92% ee.
First Ambient-pressure Superconductor Based on Ni(dmit)2, α-EDT-TTF[Ni(dmit)2]
Authors: Tajima Hiroyuki , Inokuchi Makoto , Kobayashi Akiko , Ohta Toshiaki , Kato Reizo , Kobayashi Hayao , Kuroda Haruo
Published: April 2006

The donor-acceptor type molecular conductor, α-(EDT-TTF)[Ni(dmit)2], was found to be a superconductor under ambient pressure below 1.3 K. This is the first ambient-pressure superconductor in a series of M(dmit)2 salts [M = Ni, Pd, Pt]. The sample dependence and magnetic-field dependence on the superconducting transition are described.
Preparation of Barium Tetrahydroxo Borate Crystals (Ba[B(OH)4]2)
Authors: Watanabe Koichi , Ichikawa Masayuki , Sato Shoichi
Published: April 2006

The preparation and properties of a new compound bariumtetrahydroxoborate (Ba[B(OH)4]2) are described. The crystal belongs to the monoclinic system with a = 8.33 Å, b = 16.52 Å, c = 10.22 Å, β = 107°. The properties are as follows; density = 2.83 g·cm−3, refractive indexes; α = 1.5676, β = 1.5476, γ = 1.5178.
Enzymatic Transamination to (2S)-5,5,5-Trifluoroleucine
Authors: Matsumura Yasushi , Urushihara Masahiro , Tanaka Hiroki , Uchida Keiichi , Yasuda Arata
Published: April 2006

5,5,5-Trifluoro-4-methyl-2-oxopentanoic acid was conveniently synthesized and transformed into (2S)-5,5,5-trifluoroleucine with high optical purity by enzymatic transamination using Alcaligenes faecalis IAM 1015.
Transformation of Primary Carboxamides to N-(t-Butoxycarbonyl)amines Using CuBr2–LiOBut
Authors: Yamaguchi Jun-ichi , Hoshi Kensuke , Takeda Takeshi
Published: April 2006

The reaction of primary carboxamides with the copper(II) reagent prepared from copper(II) bromide and lithium t-butoxide gave the corresponding N-(t-butoxycarbonyl)amines in good to high yields.
Stereoselective Synthesis of (E)- and (Z)-γ,δ-Unsaturated Ketones Using trans-2-Phenylthiocyclobutyl Ketones
Authors: Fujiwara Tooru , Iwasaki Toshiaki , Takeda Takeshi
Published: April 2006

The reaction of 1-methoxymethyl-2-phenylthiocyclobutanes with phenylthiotrimethylsilane followed by hydrolysis gave (E)- and (Z)-γ,δ-unsaturated ketones with high stereoselectivity. The starting materials were easily prepared by the stereoselective addition of Grignard reagents to trans-2-phenylthiocyclobutyl ketones.
Ion Beam Induced Phase Change in α-Fe2O3 and Fe3O4 Bombarded by 40 keV He+ Ions
Authors: Aratono Yasuyuki , Nakada Masami , Sagawa Chiaki , Nakashima Mikio , Saeki Masakatsu
Published: April 2006

Phase change induced by 40 keV He+ ion bombardment in α-Fe2O3 and Fe3O4 was studied by conversion electron Mössbauer spectroscopy. From the similarity of ion bombardment effect and thermal annealing behavior, the significant role of thermochemical process after the propagation of the collision cascade for the final fate of the bombarded entity was suggested.
Formation of Antiferromagnetically Coupled Dimer of [N,N′-o-Phenylenebis(salicylaldiminato)]cobalt(II) in DMF Solution
Authors: Ohashi Yukako , Nakamura Mikio
Published: April 2006

The 1H NMR signals of [N,N′-o-phenylenebis(salicylaldiminato)]cobalt(II), [Co(II)(saloph)], showed an anti-Curie behavior in DMF-d7 solution. Temperature dependence in magnetic moments suggested the formation of antiferromagnetically coupled dimeric species at low temperature.
Sensitive Detection of Saccharides by an Amphiphilic Phenylboronic Acid at the Air-Water Interface in the Presence of Quaternized Amines
Authors: Ludwig Rainer , Ariga Katsuhiko , Shinkai Seiji
Published: April 2006

The detection of mono- and disaccharides by monolayers of m-hexa decyloxyphenylboronic acid at the air-water interface becomes very sensitive if the boronic acid is located in a cationic environment provided by a water-soluble quaternized polymeric amine or a quaternized amphiphilic amine.
Direct Observation of Ordered Bilayers in Cast Films of Double-Chain Ammonium Amphiphiles by Transmission Electron Microscopy
Authors: Wakayama Yutaka , Kunitake Toyoki
Published: April 2006

Individual molecular bilayers in cast films of double-chain amphiphiles were observed directly by transmission electron microscopy upon appropriate staining. Ordering of bilayers was affected by a minor structure change of the component amphiphile.
Synthesis and Ferromagnetic Spin-Coupling of a Imidazolate-Bndged 3d-4d Cu(II)-Ru(III) Binuclear Complex
Authors: Inoue Keiji , Matsumoto Naohide , Okawa Hisashi
Published: April 2006

A 3d-4d binuclear Cu(II)-Ru(III) complex exhibiting ferromagnetic spin-coupling [Cu(A)Ru(salen)(PPh3)]ClO4·MeOH has been synthesized and characterized, where H2A = N-(2-imidazolidene)-N′-(acetylacetonylidene)ethylendiamine and H2salen = N,N′-bis(salicylidene)ethylenediamine. The magnetic susceptibility data (4.2–300 K) were well reproduced by the equation derived from H = −2JSCu·SRu (SCu = 1/2, SRu = 1/2) with g = 2.04 and J = +6.55 cm−1. The ESR study indicated that the magnetic orbitals of Cu(II) and Ru(III) are orthogonal to each other.
Convenient and Regioselective Syntheses of 3,4-Disubstituted Δ3-Pyrrolin-2-one Derivatives Starting from 2-Tosyl-3,4-Disubstituted Pyrroles
Authors: Kinoshita Hideki , Hayashi Yoshio , Murata Yasue , Inomata Katsuhiko
Published: April 2006

3,4-Disubstituted Δ3-pyrrolin-2-ones were prepared in high yields via 5-tosyl-Δ3-pyrrolin-2-ones (4) starting from 2-tosylpyrroles regioselectively. The compounds 4 were found to be useful intermediates for the preparation of a variety of Δ3-pyrrolin-2-one derivatives. The reactions of 4 with various nucleophiles and active methylene compounds bearing an appropriate leaving group are described.
Aciculatalactone, A New Elemanolide Sesquiterpenoid from Neolitsea aciculata Koidz
Authors: Takaoka Daisuke , Tani Hiroyuki , Nozaki Hiroshi , Nakayama Mitsuru
Published: April 2006

Two new elemanolides, aciculatalactone and de-O-methylsericealactone, have been isolated from Neolitsea aciculata Koidz. and their structures have been determined by using a variety of 2D NMR techniques and a X-ray crystallographic analysis.
An Efficient Synthesis of Linear Porphyrin Arrays
Authors: Osuka Atsuhiro , Tanabe Nobuhiro , Zhang Run-Ping , Maruyama Kazuhiro
Published: April 2006

Synthesis of linear porphyrin arrays of unusual length was reported. 1,4-Phenylene-bridged porphyrin oligomers up to a nonamer (ca. 122 Å length) were synthesized by acid catalyzed condensation of formyl-substituted porphyrins with dipyrrylmethane. The absorption and fluorescence spectra of these molecules exhibit systematic changes upon the increase in the number of the porphyrins.
A Convenient Synthesis of (2S,4R)-1-Acetoxy-2,4-O-Isopropylidene-1,2,5-Pentanetriol by Using Lipase Catalyzed Regio- and Enantioselective Reactions
Authors: Miyazawa Kazutoshi , Yoshida Naoyuki
Published: April 2006

(2S,4R)-1-Acetoxy-2,4-O-isopropylidene-1,2,5-pentanetriol, which is expected to be an intermediate for a synthesis of an inhibitor of HMG-CoA reductase, was synthesized by lipase catalyzed regio- and enantioselective transesterifications.
Synthesis of Optically Active Phosphorus Compounds via Metal Phosphinites Generated by Reaction of Optically Active Selenophosphinates with Phenyllithium
Authors: Kawashima Takayuki , Iwanaga Hiroki , Okazaki Renji
Published: April 2006

Sequential treatment of optically active Se-benzyl t-butylphenylselenophosphinate with PhLi and then with electrophiles such as alkyl halides and elemental selenium gave optically active phosphorus compounds in good chemical and optical yields with a retention of configuration at phosphorus atom, together with benzyl phenyl selenide.
A Fluorescent Host. Direct Monitoring of Multiple Hydrogen-Bonding Interaction by the Specific Fluorescence of the Aromatic Amide Unit
Authors: Abe Masanori , Otsuki Joe , Araki Koji
Published: April 2006

The host 1 having aromatic amide structure exhibits an anomalous fluorescence with a large Stokes shift at around 500 nm, and multiple hydrogen-bonding interaction of the host 1 with uracil derivatives is directly monitored by increase of this fluorescence intensity when the amide bond rotation is affected by the association.
Epoxidation of Olefinic Compounds with Combined Use of Molecular Oxygen and Propionaldehyde Diethyl Acetal Catalyzed by Cobalt(II) Complex. Efficient Method for the Preparation of Acid-sensitive Epoxides
Authors: Yorozu Kiyotaka , Takai Toshihiro , Yamada Tohru , Mukaiyama Teruaki
Published: April 2006

Synthesis of acid-sensitive epoxides such as epoxide of bishomoallyl alcohol or chromene oxide was achieved by the epoxidation of corresponding olefins with combined use of molecular oxygen and propionaldehyde diethyl acetal catalyzed by cobalt(II) complex. Various silyl enol ethers and silyl ketene acetals, acid-sensitive compounds, were also smoothly monooxygenated into the corresponding α-hydroxy carbonyl compounds.
Dramatic Differences in the Effectiveness among Various Coupling Methods in the Synthesis of Peptides Containing α,α-Diphenylglycine
Authors: Yamada Takashi , Omote Yuichiro , Nakamura Yoshio , Miyazawa Toshifumi , Kuwata Shigeru
Published: April 2006

Both couplings of N-benzyloxycarbonyl-α,α-diphenylglycine (Z-Dph) with methyl esters of various amino acids (AA-OMe) and Z-AA with Dph-OMe by various methods can yield Z-Dph-AA-OMe and Z-AA-Dph-OMe, respectively. Yields of the dipeptides remarkably differ from over 90% to 0% depending on the coupling method employed.
Convenient Synthesis of Oxo-Linked 5a-Carba-di- and tri-saccharides of Biological Interests
Authors: Ogawa Seiichiro , Sasaki Shin-ichi , Tsunoda Hidetoshi
Published: April 2006

Some oxo-linked 5a-carba-di- and tri-saccharides of biological interests including 5a-carbamaltose, were synthesized by coupling of 5a-carba-glycosyl donor, 1,2-anhydro-5a-carba-β-d-mannopyranose derivative with the alkoxides generated from the protected hexopyranose derivatives in N,N-dimethylformamide in the presence of a crown ether.
Alkali Metal Selectivity of Calix[n]aryl Acetates as Estimated by Mass Spectrometry on the Relative Stability of the 2:1 Metal/Calix[n]arene Complex
Authors: Inokuchi Fumiaki , Shiomi Yutaka , Kawabata Hirosuke , Sakaki Toru , Shinkai Seiji
Published: April 2006

It was found that the metal selectivity of calix[n]aryl acetates (n = 4, 6, and 8) can be conveniently estimated by mass spectrometry. The results have disclosed several new phenomena which cannot be found through conventional solvent extraction.
Orbital Phase Continuity Requirements in Triplet States
Authors: Iwase Koji , Inagaki Satoshi
Published: April 2006

Orbital phase continuity requirements were derived for stabilizing triplet states, and successfully applied to acyclic conjugated diradicals.
Electrochemical Conversion of Alcohols into Aldehydes Mediated by Lipophilic β-Cyclodextrin Bearing a Ferrocene Moiety
Authors: Suzuki Iwao , Chen Qiang , Kashiwagi Yoshitomo , Osa Tetsuo , Ueno Akihiko
Published: April 2006

A lipophilic β-cyclodextrin bearing a ferrocene moiety in which remaining hydroxyl groups were acetylated showed a quasireversible redox property in acetonitrile. In the presence of benzyl alcohol or 1-naphthalene methanol, a catalytic current was observed. The results of macroelectrolyses indicated that the electroactive host could oxidize these alcohols into the corresponding aldehydes efficiently and selectively.
On the Unusual Conformation of Calix[4]arene Which Appears in the Tricarbonylchromium Complexes
Authors: Iki Hideshi , Kikuchi Taketoshi , Tsuzuki Hirohisa , Shinkai Seiji
Published: April 2006

The structures of arene-tricarbonylchromium complexes prepared from cone-25,26,27,28-tetrapropoxycalix[4]arene and Cr(CO)6 were studied by an X-ray crystallographic method: they showed an unusual conformation with a pair of faced gable-like roofs, which is extraordinarily transformed from a cone conformation.
Photomechanical Effect in Monolayers of Azobenzene Side Chain Polymers
Authors: Seki Takahiro , Tamaki Takashi
Published: April 2006

Expansionshrinkage behaviors of photoresponsive monolayers at the air/water interface are investigated using azobenzene side chain polymers. Influence of the spacer length implies that the photomechanical effect in the present systems is attributed to the reversible on/off contact of the azobenzene side unit with the water surface.
A Photoelectrochemical Fixation of Carbon Dioxide. Spontaneous Up Quality Conversion of Organic Compound
Authors: Ueda Jo-ji , Nakabayashi Seiichiro , Ushizaki Jun-ichi , Uosaki Kohei
Published: April 2006

A photosynthetic semiconductor electrochemical cell with Mg electrode as a sacrificial anode was assembled. This photoelectrochemical cell spontaneously fixes carbon dioxide into organic molecule such as benzyl chloride to form phenyl acetic acid which costs 7.5 times more than the sources. Among the semiconductor electrodes investigated, p-GaP showed highest current efficiency, 47%.
Novel Synthesis of Perfluoroalkylated Phenylboronic Acid with Low pKa Using Bis(heptafluorobutyryl)peroxide as Perfluoroalkylation Reagent
Authors: Shiino Daijiro , Kim Yong Joo , Murata Yoshishige , Yamaguchi Masahiko , Kataoka Kazunori , Koyama Yoshiyuki , Yokoyama Masayuki , Okano Teruo , Sakurai Yasuhisa
Published: April 2006

3-Acetamido-6-heptafluoropropylphenylboronic acid was synthesized by the perfluoroalkylation of 3-acetamidophenylboronic acid (pKa = 8.3) with bis(heptafluorobutyryl)peroxide. The perfluoroalkylated phenylboronic acid thus prepared was determined to have a low pKa as 6.6 by potentiometric titration. Lowered pKa suggests that the product has an advantage for binding with polyols under physiological pH, opening a wide application in the field of biological as well as material sciences.
An Unusual Self-Assembly of 2-Thiouracil Derivative. Synthesis and Crystal Structure of Bis(ethane-1,2-diamine)[5-((1′H)-4′-oxo-6′-aminopyrimidin-2′-yl)thio]-6-amino-2-thiouracilatocobalt(III) Perchlorate
Authors: Yamanari Kazuaki , Kida Makiko , Yamamoto Masahiro , Fujihara Takashi , Fuyuhiro Akira , Kaizaki Sumio
Published: April 2006

An unusual red complex [Co(di-Hatuc)(en)2]+ (di-Hatuc = [5-((1′H)-4′-oxo-6′-aminopyrimidin-2′-yl)thio]-6-amino-2-thiouracilate (2−); en = ethane-1,2-diamine) is formed by a simple thermal reaction. This complex has both a intramolecular hydrogen bond and novel linear intermolecular hydrogen bonds, the latter being analogous to hydrogen bonding in nucleic acids.
Liquid Phase Formation of Spinel Surface Layers on Hexaaluminate Microcrystals
Authors: Machida Masato , Murakami Manabu , Sato Akihiro , Kijima Tsuyoshi , Arai Hiromichi
Published: April 2006

Spinel oxide (Mn3O4) surface layers were produced on hexaaluminate microcrystals by means of the air-oxidation process. The surface layer completely covered the basal plane of hexagonal facets as evident from HREM observation and CO2 chemisorption measurement. The catalytic activity for methane oxidation was strongly enhanced by this modification.
Total Synthesis of Aureobasidin A, an Antifungal Cyclic Depsipeptide
Authors: Kurome Toru , Inami Kaoru , Inoue Tetsuya , Ikai Katsushige , Takesako Kazutoh , Kato Ikunoshin , Shiba Tetsuo
Published: April 2006

A total synthesis of an antifungal cyclic depsipeptide aureobasidin A was first achieved mainly using PyBroP1) as a coupling reagent. The synthetic cyclized product was completely identical with the natural antibiotic in all respects. Some unexpected reactions due to N-methylamino acid were also described.
Solution Structure of a Peptide Designed on Plastocyanin Metal Center in Trifluoroethanol and Incorporation of Cobalt(II) into the Peptide
Authors: Zaima Hiroaki , Ueyama Norikazu , Nakamura Akira , Aimoto Saburo
Published: April 2006

A novel sixteen amino acid peptide which has a portion of the conserved amino acid sequence of potato plastocyanin was synthesized. Its solution structure in trifluoroethanol (TFE) was determined by 1H NMR spectroscopy. Incorporation of cobalt(II) ion into the peptide having a turn structure was examined. Cys6, His9, and Met14 of the peptide in TFE are located close to each other and suitable to bind a metal ion. Incorporation of Co(II) ion to the peptide results in formation of tetrahedral coordination site.
Continuous Removal of SO2 in the Model Flue Gas over PAN-ACF with Recovering Aqueous H2SO4
Authors: Kisamori Seiki , Kawano Shizuo , Mochida Isao
Published: April 2006

SO2 was adsorbed, oxidized, hydrated, and recovered continuously as aq. H2SO4 at 30–100 °C on a polyacrylonitrile based active carbon fiber (PAN-ACF-FE-300). SO2 of 1000 ppm in a model flue gas was removed completely for longer than 60 h at 30 and 50 °C by W/F = 5.0 × 10−3 g min ml−1 by supplying sufficient humidity of 10 and 20 vol%, respectively. The heat-treatment of the ACF at 800 °C was found very effective to enhance the catalytic activity.
A Facile and Highly Regioselective Conversion of Epoxides to Bromohydrins Using Tetrabutylammonium Bromide and Magnesium Nitrate
Authors: Suh Young-Ger , Koo Bon-Am , Ko Jung-Ae , Cho Youn-Sang
Published: April 2006

Reaction of epoxides with nBu4NBr in the presence of Mg(NO3)2 as a catalyst affords vicinal bromohydrins in excellent yields via regioselective ring opening of the unsymmetrical epoxides.
An Improved Synthetic Method for Both Enantiomers of Tricyclo[5.2.1.02,6]deca-4,8-dien-3-one by Means of Chemoenzymatic Dissymmetrization of a meso-Compound
Authors: Sato Masayuki , Hattori Hanae , Murakami Masayuki , Kaneko Chikara
Published: April 2006

Diels-Alder reaction of cis-1,4-diacetoxy-2-cyclopentene with cyclopentadiene gave a tricyclo[5.2.1.02,6]decene derivative stereoselectiviely. The titled dienone useful for enantioselective synthesis of cyclopentanoids and other natural products has been efficiently prepared from the adduct by means of dissymmetrization with lipase-catalyzed acetylation.
Production and Immunological Characterization for Anti Hemin Monoclonal Antibody
Authors: Uda Taizo , Okawa Yumi , Umenobu Takako , Hifumi Emi , Ogino Keiki
Published: April 2006

By using three kinds of antigens for immunization, screening and confirmation, a monoclonal antibody for hemin was produced. The probability of the antibody secreting fused cells was extremely low compared with the normal cell fusion. The antibody could also react some other metal substituted protoporphyrins such as Mn, Pd, Zn and Ga instead of Fe. The monoclonal antibody may loosely recognize the porphyrin ring unlike hemoglobin.
The Role of Oxygen in the Reduction of NO with Propene over Rh/Al2O3 in Oxidizing Atmosphere
Authors: Naito Shuichi , Tanimoto Mitsutoshi
Published: April 2006

Infrared spectroscopy and isotopic tracer technique with microwave spectroscopy revealed a marked change of reaction intermediates as well as reaction mechanisms by the presence of excess oxygen in NO-propene reaction over highly dispersed Rh/Al2O3 catalyst.
Catalytic Synthesis of β-D-Ribofuranosides from D-Ribofuranose and Alcohols
Authors: Shimomura Naoyuki , Mukaiyama Teruaki
Published: April 2006

Catalytic synthesis of β-D-ribofuranosides from C-1 free ribofuranose, 2,3,5-tri-O-benzyl-D-ribofuranose, and alcohols is efficiently performed by combined use of silver salts and Lawesson’s reagent, [2,4-bis(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane-2,4-disulfide], or silver salts and diphenyltin sulfide (Ph2Sn=S) under mild conditions.
Electrochemical Oxidation of Hydrosilanes. A Synthetic Approach to Halosilanes and Disilanes
Authors: Kunai Atsutaka , Kawakami Toshihiro , Toyoda Eiji , Sakurai Tomohiro , Ishikawa Mitsuo
Published: April 2006

Electrolytic oxidation of dimethylphenylsilane (1) in the presence of CuCl2 or CuCl afforded chlorodimethylphenylsilane in high yields ( >90%), while similar electrolysis of 1 in the presence of BF4− ions afforded fluorodimethylphenylsilane in 90% yield. 1,2-Diphenyltetramethyldisilane was obtained from 1 in 48% yield by the electrolysis with a Pt–Cu electrode system. A “paired” electrolysis of methyldiphenylsilane on the anode and chloromethyldiphenylsilane on the cathode afforded 1,2-dimethyltetraphenyldisilane in 64% yield.
Synthesis and Aggregate Morphology of Protoporphyrin IX Derivative Having Phospholipid Residue
Authors: Komatsu Teruyuki , Arai Kenji , Nishide Hiroyuki , Tsuchida Eishun
Published: April 2006

A protoporphyrin IX derivative having a phospholipid residue (lipid-porphyrin) was synthesized. The lipid-porphyrin itself formed an oval multilamellar vesicle in an aqueous medium. The spectral features of the lipid-porphyrin vesicle indicated a stacked configuration of the porphyrin moiety.
Transformation of C≡C Triple Bond of Poly(aryleneethynylene) Type Polymers to C=C Double Bond
Authors: Yamamoto Takakazu
Published: April 2006

C≡C triple bond of poly(aryleneethynylene) type polymer is converted to C=C double bond by the reaction with HBr, and the =C–Br group thus formed is further transformed to an ester group.
Photochemical Micropatterning of Silylated Glass Surface Bearing 3-Phenyldithiopropyl Group by KrF Laser Irradiation
Authors: Ichinose Nobuyuki , Sugimura Hiroyuki , Uchida Tatsuya , Shimo Nobuo , Masuhara Hiroshi
Published: April 2006

Thin film of 3-phenyldithiopropyltrimethoxysilane (1) was prepared as a photoreactive surface of masked thiol by in-situ reaction of 3-mercaptopropyltrimethoxysilane (2) with diphenyldisulfide before deposition of the film on quartz substrate. The film of 1 undergoes photochemical oxygenation of sulfur atom more efficiently than that of 2 upon KrF laser (248 nm) irradiation, where a thiyl radical is incorporated as a common intermediate.
Hydrogenolysis of gem-Diphenylcyclopropanes Fused with Trihalogenated Quinones
Authors: Oshima Takumi , Nakajima Yu-ichi , Nagai Toshikazu
Published: April 2006

Palladium-catalyzed hydrogenolysis of gem-diphenylcyclopropanes fused with trihalogenobenzoquinones gave diphenylmethylhydroquinones. Water took part in the reaction to yield α-hydroxydiphenylmethyl- and benzoylhydroquinones. The selective ring-cleavage was interpreted in terms of the π-conjugative interaction of cyclopropane.
Direct Electrochemistry of Copper-Containing Nitrite Reductase from Achromobacter xylosoxidans NCIB 11015
Authors: Kohzuma Takamitsu , Shidara Sohsuke , Yamaguchi Kazuya , Nakamura Nobuhumi , Deligeer  , Suzuki Shinnichiro
Published: April 2006

Nitrite reductase containing type I and type II coppers from Achromobacter xylosoxidans NCIB 11015 shows the direct electrochemical response corresponding to the type I copper site at a di-(4-pyridyl) disulfide (4-pyds) modified gold electrode.
Ionic Conductivity of β-Fe2(SO4)3 Type Li3Cr2(PO4)3 Based Electrolyte
Authors: Aono Hiromichi , Sugimoto Eisuke , Sadaoka Yoshihiko , Imanaka Nobuhito , Adachi Gin-ya
Published: April 2006

The electrical properties were studied for the (1-y)Li3Cr2(PO4)3-yLi5Mg2(PO4)3 system. The Mg2+ ion can not replace the Cr3+ site. The crystal structure for Li3Cr2(PO4)3 in this system is the β-Fe2(SO4)3 type monoclinic phase. The conductivity and the sinterability improve with the increase in y for the phosphate system. The maximum conductivity was 4.6 × 10−5 S·cm−1 at 298 K for y = 0.2. The activation energy for a Li+ ion migration at the bulk component was ca. 0.43 eV for all the samples.
Simultaneous Determination of Cysteine and Glutathione via Use of Time-Resolved Luminol Chemiluminescence Method
Authors: Kamidate Tamio , Kuniya Isao , Watanabe Hiroto
Published: April 2006

Hydrogen peroxide produced successively from the copper(II)-catalyzed oxidation of both cysteine (CySH) and glutathione (GSH) was detected using arthromyces ramosus peroxidase (ARP)-catalyzed luminol chemiluminescence (CL) reaction. Two peaks appeared in the CL responce curve. The former peak was due to CySH while that of the latter to GSH. The time-resolved luminol CL signals were applied for the simultaneous determination of CySH and GSH.
Novel Metal Substitution Reactions in Amidate-Bridged Binuclear Complexes [M2(bpy)2(3,3-DMGI)2]2+ (M = Pt(II), Pd(II); bpy = 2,2′-bipyridine; 3,3-DMGI = 3,3-dimethylglutarimidate)
Authors: Matsumoto Kazuko , Urata Hiroshi
Published: April 2006

The reaction of [Pt2(bpy)2(3,3-DMGI)2]2+ with Pd(bpy)Cl2 produces [PtPd(bpy)2(3,3-DMGI)2]2+. The same compound is obtained also from the reaction of [Pd2(bpy)2(3,3-DMGI)2]2+ with Pt(bpy)Cl2. The crystal structures of these complexes are reported.