bluuebunny/crossref_metadata_2025 huggingface dataset:
The effect of hydroxyapatite and growth factors on reparative dentine formation in the therapy of injured pulp
Authors: Velickovic Zorana , Zivkovic Dusan , Bubalo Marija , Zivkovic Milan , Mitic Aleksandar , Miladinovic Milan , Duka Milos , Lazic Dragoslav
Published: March 2019

Background/Aim. The studies of hydroxyapatite (HAp) and growth factors as the materials used for direct pulp capping have produced conflicting results for both the issue of the inflammatory response and the issue of calcified bridge formation. Hap/poly (lactide-co-glycolide) (HAp/PLGA) is a bioresorbable polymer with demonstrated good characteristics as the carrier for the bone morphogenetic protein necessary in bone tissue regeneration. The role of growth factors in dental tissue reparation (in both reactionary and reparative dentinogenesis) represents the new foundation and provides a different approach to dental pulp treatment. Growth factors ? transforming growth factor beta-1 (TGF-?-1) ? directly induce morphological and functional differentiation of neo-odontoblasts. The aim of this study was to investigate the effect of calcium HAp/PLGA and growth factors (TGF ?-1) in the formation of a calcified tissue ? dentine bridge ? on the teeth of our experimental model. Methods. In this experimental study, rodent (rabbit) teeth were used as the animal model. After the trepanation of pulp space with sterile steel drills, the pulp was capped with calcium HAp/PLGA (experimental group I; n = 60); calcium HAp/PLGA combined with TGF ?-1 growth factor (experimental group II; n = 60), and there was a control group of intact teeth (n = 20). The experiment was performed in general anesthesia. The animals were kept alive for 1, 3, and 6 months. The extracted teeth were adequately prepared for scanning electron microscopy. Results. Scanning electron microscopy demonstrated that the number of teeth with calcified tissue in the form of dental bridges in the HAp/PLGA+TGF ?-1 group, 6 months after the treatment, was statistically significantly greater (66.67%) than after 3 months (26.67%), at the statistical significance level of p < 0.05. Conclusion. Direct pulp capping covers the artificially exposed dental pulp and makes possible the formation of a dentine bridge (a tubular structure composed of reparative dentine) in the period of 3 months.
Morphometric analysis of glomeruli, clinical features and outcome in obese and non-obese focal segmental glomerulosclerosis patients
Authors: Jordanova Elena , Jankovic Radmila , Naumovic Radomir , Celic Dejan , Ljubicic Bojana , Simic-Ogrizovic Sanja , Basta-Jovanovic Gordana
Published: March 2019

Background/Aim. In the past three decades focal segmental glomerulosclerosis
(FSGS) was commonly regarded as a part of obesity related glomerulopathy
(ORG) a distinct entity featuring proteinuria, glomerulomegalia, progressive
glomerulosclerosis and renal functional decline. The aims of the present
study were to evaluate the glomerular morphometry, clinical features and two
years outcome in obese and non-obese FSGS patients. Methods. The study
included 35 FSGS patients (23 males, age 46.5?15.2 years); divided in two
groups: obese (BMI ?27 kg/m2- 18 patients, age 47.2?15.5 years) and
non-obese (BMI <27 kg/m2- 17 patients, age 45.7?15.2 years). The serum
concentrations of proteins, albumin, cholesterol, triglyceride and
creatinine were determined at the time the biopsy, 6, 12, 24 months after
the biopsy. Formulas Cockcroft- Gault (BMI <27 kg/m2) and
Cockcroft-GaultLBW(BMI ?27 kg/m2) were calculated. Glomerular radius (GR),
glomerular volume (GV) and glomerular density (GD) were compared
morphometrically between two groups. Results. At the time of kidney biopsy
and 6 months later the obese had significantly lower GFR compared to
non-obese. After 24 months follow-up there wasn?t any difference between
groups. Obese had significantly higher GR (109.44?6,03 ?m vs 98.53?14,38 ?m)
and GV (3.13?0.49 x106 ?m3 vs 2.26?0.83 x106 ?m3),only midly lower GD
(1.91?0.39/mm2 vs 1.95?0.61/mm2) compared to non-obese. Significant positive
association between GV and BMI (r=0.439) was found. After 12 months
follow-up significantly higher percentage of non-obese patients reached
complete remission (71.4% vs 37.5%) compared to obese (?2=0.041), but after
24 months there were no significant difference. Conclusion. Obese patients
at the time of kidney biopsy and 6 months later had already the significant
lower kidney function compared to non-obese. However, after 12 and 24
months, this difference was still lower and without significance as well as
after 24 months percentage of patients with complete remission between two
groups.
Fpr2 Deficiency Alleviates Diet-Induced Insulin Resistance Through Reducing Body Weight Gain and Inhibiting Inflammation Mediated by Macrophage Chemotaxis and M1 Polarization
Authors: Chen Xiaofang , Zhuo Shu , Zhu Tengfei , Yao Pengle , Yang Mengmei , Mei Hong , Li Na , Ma Fengguang , Wang Ji Ming , Chen Shiting , Ye Richard D. , Li Yu , Le Yingying
Published: March 2019

Obesity and related inflammation are critical for the pathogenesis of insulin resistance, but the underlying mechanisms are not fully understood. Formyl peptide receptor 2 (FPR2) plays important roles in host immune responses and inflammation-related diseases. We found that Fpr2 expression was elevated in the white adipose tissue of high-fat diet (HFD)–induced obese mice and db/db mice. The systemic deletion of Fpr2 alleviated HFD-induced obesity, insulin resistance, hyperglycemia, hyperlipidemia, and hepatic steatosis. Furthermore, Fpr2 deletion in HFD-fed mice elevated body temperature, reduced fat mass, and inhibited inflammation by reducing macrophage infiltration and M1 polarization in metabolic tissues. Bone marrow transplantations between wild-type and Fpr2−/− mice and myeloid-specific Fpr2 deletion demonstrated that Fpr2-expressing myeloid cells exacerbated HFD-induced obesity, insulin resistance, glucose/lipid metabolic disturbances, and inflammation. Mechanistic studies revealed that Fpr2 deletion in HFD-fed mice enhanced energy expenditure probably through increasing thermogenesis in skeletal muscle; serum amyloid A3 and other factors secreted by adipocytes induced macrophage chemotaxis via Fpr2; and Fpr2 deletion suppressed macrophage chemotaxis and lipopolysaccharide-, palmitate-, and interferon-γ–induced macrophage M1 polarization through blocking their signals. Altogether, our studies demonstrate that myeloid Fpr2 plays critical roles in obesity and related metabolic disorders via regulating muscle energy expenditure, macrophage chemotaxis, and M1 polarization.
Diabetes-Induced DUSP4 Reduction Promotes Podocyte Dysfunction and Progression of Diabetic Nephropathy
Authors: Denhez Benoit , Rousseau Marina , Dancosst David-Alexandre , Lizotte Farah , Guay Andréanne , Auger-Messier Mannix , Côté Anne Marie , Geraldes Pedro
Published: March 2019

Diabetic nephropathy (DN) remains the leading cause of end-stage renal disease. Hyperglycemia-induced podocyte dysfunction is a major contributor of renal function impairment in DN. Previous studies showed that activation of mitogen-activated protein kinase (MAPK) in diabetes promotes podocyte dysfunction and cell death. Dual specificity phosphatases (DUSPs) are a family of phosphatases mainly responsible for MAPK inhibition. In this study, we demonstrated that diabetes and high glucose exposure decreased DUSP4 expression in cultured podocytes and glomeruli. Diabetes-induced DUSP4 reduction enhanced p38 and c-Jun N-terminal kinase (JNK) activity and podocyte dysfunction. The overexpression of DUSP4 prevented the activation of p38, JNK, caspase 3/7 activity, and NADPH oxidase 4 expression induced by high glucose level exposure. Deletion of DUSP4 exacerbated albuminuria and increased mesangial expansion and glomerular fibrosis in diabetic mice. These morphological changes were associated with profound podocyte foot process effacement, cell death, and sustained p38 and JNK activation. Moreover, inhibition of protein kinase C-δ prevented DUSP4 expression decline and p38/JNK activation in the podocytes and renal cortex of diabetic mice. Analysis of DUSP4 expression in the renal cortex of patients with diabetes revealed that decreased DUSP4 mRNA expression correlated with reduced estimated glomerular filtration rate (<60 mL/min/1.73 m2). Thus, this study demonstrates that preserving DUSP4 expression could protect against podocyte dysfunction and preserve glomerular function in DN.
A Thermogenic-Like Brown Adipose Tissue Phenotype Is Dispensable for Enhanced Glucose Tolerance in Female Mice
Authors: Winn Nathan C. , Acin-Perez Rebeca , Woodford Makenzie L. , Hansen Sarah A. , Haney Megan M. , Ayedun Lolade A. , Rector R. Scott , Vieira-Potter Victoria J. , Shirihai Orian S. , Sacks Harold S. , Kanaley Jill A. , Padilla Jaume
Published: March 2019

The prevailing dogma is that thermogenic brown adipose tissue (BAT) contributes to improvements in glucose homeostasis in obesogenic animal models, though much of the evidence supporting this premise is from thermostressed rodents. Determination of whether modulation of the BAT morphology/function drives changes in glucoregulation at thermoneutrality requires further investigation. We used loss- and gain-of-function approaches including genetic manipulation of the lipolytic enzyme Pnpla2, change in environmental temperature, and lifestyle interventions to comprehensively test the premise that a thermogenic-like BAT phenotype is coupled with enhanced glucose tolerance in female mice. In contrast to this hypothesis, we found that 1) compared to mice living at thermoneutrality, enhanced activation of BAT and its thermogenic phenotype via chronic mild cold stress does not improve glucose tolerance in obese mice, 2) silencing of the Pnpla2 in interscapular BAT causes a brown-to-white phenotypic shift accompanied with inflammation but does not disrupt glucose tolerance in lean mice, and 3) exercise and low-fat diet improve glucose tolerance in obese mice but these effects do not track with a thermogenic BAT phenotype. Collectively, these findings indicate that a thermogenic-like BAT phenotype is not linked to heightened glucose tolerance in female mice.
Is Material Management Required In Management Silver Craft SMEs? (Case Study in Gianyar Regency of Bali Province. Indonesia)
Authors: Wijaya Putu Yudy , Rahyuda I Ketut , Yasa Ni Nyoman Kerti , Ukaatmadja I Putu Gde
Published: March 2019

The craft industry is growing rapidly in Bali as a support for the tourism sector, moreover Bali is a world tourist destination. One of them is silver craft, which has now developed as a fashion value product. To create a competitive product, which has quality, quality and uniqueness, of course management material (in this case silver as raw material) needs to be considered. The purpose of this study is to analyze the influence of innovation and competitive advantage on business performance, as well as the role of material management on the influence of competitive advantage on the business performance of silver craft SMEs in the Province of Bali. The population in the study was silver craft SMEs in Gianyar Regency, which is the center of the silver industry in Indonesia. The sample size is determined by the formula Isaac and Michael, so that a sample of 146 respondents was obtained. Data was collected through questionnaires and independent interviews. Furthermore, the data were analyzed using the SEM-PLS approach. The results of data analysis show that competitive advantage has a positive and significant effect on business performance, while material management directly or as a moderator turns out to have no significant effect on business performance. It is recommended that silver craftsmen do material management in a simple but careful manner, and focus more on forming product competitiveness.
Soil ‘Organic’ Phosphorus: An Untapped Resource for Crop Production?
Authors: Mezeli Malika , Haygarth Phil , George Timothy , Neilson Roy , Blackwell Martin
Published: March 2019

Soils with a history of P fertilizer application may represent a significant ‘bank’ of residual soil P. The P research community offers potential and emerging strategies for land managers to access this soil resource to create sustainable P management strategies that may rely less on inorganic fertilizers and aid in closing the P cycle.
Root/Rhizosphere Management for ImprovingPhosphorus Use Efficiency and Crop Productivity
Authors: Wang Liyang , Shen Jianbo
Published: March 2019

Rhizosphere processes affect soil P availability and efficient use of P by plants. This paper summarizes the principles of root/rhizosphere management, and highlights case studies on how to exploit root-soil-microbe interaction processes to improve crop productivity and P use efficiency.
Phosphogypsum: P Fertilizer By-Product and Soil Amendment
Authors: Kalinitchenko Valery , Nosov Vladimir
Published: March 2019

This review outlines the use of phosphogypsum, a by-product from the phosphate fertilizer industry, in Russia including its ameliorative roles for Na-affected and compacted soils; its value as a multi-nutrient fertilizer; in composting with various organic wastes to produce organo-mineral fertilizers; and in remediation of oil-contaminated soil.
The Future of Phosphorus Use in Agriculture
Authors: McLaughlin Michael
Published: March 2019

Securing the nutritional needs for our increasing population will continue to drive a healthy demand for P. Innovation will continue to broaden our viable choices for P, which combined with social drivers, will continue to generate momentum towards a more closed P cycle. Further advances in plant breeding, agronomy, and fertilizer technology are required for today’s agricultural systems on soils with high P sorption capacity.
Where are children and adults physically active and sedentary? – a rapid review of location-based studies
Authors: Prince Stephanie A. , Butler Gregory P. , Rao Deepa P. , Thompson Wendy
Published: March 2019

Introduction

Geographical positioning systems (GPS) have the capacity to provide further context around where physical activity (PA) and sedentary time (ST) are accrued especially when overlaid onto objectively measured movement. The objective of this rapid review was to summarize evidence from location-based studies which employed the simultaneous use of GPS and objective measures of PA and/or ST.

Methods

Six databases were searched to identify studies that employed the simultaneous use of GPS and objective measures of PA or ST to quantify location of movement. Risk of bias was assessed, and a qualitative synthesis completed.

Results

Searching identified 3446 articles; 59 were included in the review. A total of 22 studies in children, 17 in youth and 20 in adults were captured. The active transportation environment emerged as an important location for moderate-to-vigorous intensity physical activity (MVPA) in children, youth and adults. In children and youth, the school is an important location for MVPA, especially the schoolyard for children. Indoor locations (e.g., schools, homes) appear to be greater sources of lighter intensities of PA and ST. The review was limited by a lack of standardization in the nomenclature used to describe the locations and methods, as well as measures of variance.

Conclusion

Evidence suggests that the active transportation environment is a potentially important contributor of MVPA across an individual’s lifespan. There is a need for future location-based studies to report on locations of all intensity of movement (including minutes and proportion) using a whole-day approach in larger representative samples.
Estrategia de gestión de la energía en vehículos eléctricos con pila de combustible y sistema de almacenamiento híbrido utilizando control predictivo económico
Authors: Sampietro José Luis , Puig Vicenc , Costa Castelló Ramon
Published: March 2019

En este trabajo se propone el control predictivo económico como técnica para la gestión energética óptima de un vehículo híbrido. Se describe el modelo utilizado para el control y a partir del mismo se diseña un controlador predictivo económico. Finalmente, se estudia el mejor ajuste de los pesos del controlador que consiga la mayor reducción del consumo de la pila de combustible con la ayuda de baterías y supercapacitores. Para ello se determinan los puntos de consumo máximo y mínimo de la pila de combustible, y se caracteriza el problema de control multiobjetivo mediante la determinación de las curvas de Pareto. El artículo concluye con una discusión de los resultados y los trabajos futuros
COMMUNICATING CSR ON TOURISM INDUSTRY; A PRELIMINARY CASE STUDY OF BALI
Authors: Putra Kadek Dwi Cahaya , Putra I Komang Mahayana , Kencanawati A A.A. Mirah
Published: March 2019

As one of the world’s and Indonesia’s most important tourist destination, Bali tourism sector has significantly contributed to both Indonesia’s and Bali’s economy. This study explores how tourism companies communicate CSR including goals, audiences, contents, channels, and strategy. Data are gathered through a single case study approach and thirteen semi-structured interviews to the representatives of hotels, restaurants, tour and travels, and tourism companies in Bali. Data are analyzed by using QDA Miner software. The result shows that relationships, reputation, and branding are the most common goals of communicating CSR. The companies communicated mostly to internal stakeholders; employees and owner, to customers, and the local community. However, there was no specific policy on contents. The companies use reports, meeting, announcement board, e-mail, and in-house communication system to communicate with internal stakeholders; social media, employee, and CSR involvement to communicate with customers; and newspaper, social media, TV, meeting, and employee to communicate to society. An involving strategy was prevalently used mainly through dialogic meeting with the employees and the local community
Kendala-Kendala BKB (Bina Keluarga Balita) Holistik Integratif di Provinsi Sulawesi Utara
Authors: Wijayanti Urip Tri
Published: March 2019

The development of early childhood needs to be done holistik integrative. The service activities cover the aspects of care, health and nutrition. All Of whice can be obtained through posyandu; Aspects of education through early childhood (early childhood education) and aspects of parenting through Bina Keluarga Balita (BKB) are carried out and applied in an integrated manner. Training and guidance for integrated integrative BKB cadres has been done. The question is, after the cadres get training and coaching whether they can do integration between early childhood and Posyandu or there are obstacles that they face.For that need to be done research, this research is a qualitative research with BKB cadres, PAUD cadres & Posyandu cadres and families who become members of BKB. The results of this study concluded that the obstacles in the implementation Holistik integrative BKB include: (1). Lack of commitment among relevant sectors and partners, so there are not willing to provide integrative services with BKB. (2) Low quality data that is hindering the development of the group BKB Integrative Holistik in the district / city(3). The low quality of cadres and PLKB, so an understanding of Integrative Holistik BKB still less so (4).The low awareness of parents to be active in the activities of BKB.  Pengembangan anak usia dini perlu dilakukan secara holistik integrative Kegiatan pelayanan yang dilakukan mencakup aspek perawatan, kesehatan dan gizi. Kesemuaya itu bisa didapat melalui posyandu; aspek pendidikan melalui PAUD (pendidikan anak usia dini) dan aspek pengasuhan melalui Bina Keluarga Balita (BKB) yang dilakukan dan diterapkan secara terpadu. Pelatihan dan pembinaan bagi kader-kader BKB Holistik integratif sudah dilakukan,menjadi pertanyaan kita, setelah para kader  mendapatkan pelatihan dan pembinaan apakah  mereka sudah bisa melakukan integrasi antara PAUD dan Posyandu atau ada kendala-kendala yang mereka hadapi.Untuk itu perlu dilakukan penelitian, penelitian ini merupakan penelitian kualitatif dengan informan Kader BKB, Kader PAUD & Kader Posyandu serta keluarga yang menjadi anggota BKB.Hasil penelitiannya antara lain (1).Rendahnya Komitmen antar sector terkait dan mitra kerja, sehingga masih ada yang belum mau memberikan pelayanan secara integrative dengan BKB. (2) Rendahnya Kualitas Data BKB sehingga menghambat pengembangan kelompok BKB Holistik Integratif di kabupaten/kota. (3). Rendahnya kualitas kader & PLKB, sehingga pemahaman tentang BKB Holistik integratif masih kurang sekali (4). Rendahnya kesadaran orangtua untuk aktif dalam kegiatan BKB.
Infografis Dinamis Sebagai Pengganti Peta Konvensional pada Kawasan Bermain (Studi Kasus : Dunia Fantasi)
Authors: Valentina Anny , Andrew Richard
Published: March 2019

A map that was originally used as a hint tool to visit a new area or environment, especially if the area visited is wide enough. Start from visiting the new city to the play area. Dunia Fantasi (Dufan) is a large playing area. Until now Dufan provides a map of the area in the form of brochures and standing maps in the play area. With the advancement of technology today is very possible if Dufan can make the navigation system map of its region in digital form. As is known today human habits have changed a lot, because it is very likely to move the map from manual to digital system will be preferred by consumers. Map of digital form because it is considered more practical and easy, especially if the form of dynamic infographic. Infographics itself is a collection of information with the help of images, dynamic use can be interpreted with the addition of motion elements in the map. Using data collection techniques in the form of direct observation and interview. The target of the research is for Dufan visitors covering all ages, ranging from students, students and families and through this research is expected to know what information needed by visitors and media and design that is considered efficient and easy to understand, so through the media map can increase consumer satisfaction.  Peta yang pada awalnya digunakan sebagai alat bantu petunjuk untuk mengunjungi sebuah area atau lingkungan baru, apalagi jika area yang dikunjungi cukup luas.  Mulai dari mengunjungi kota baru hingga area bermain. Dunia Fantasi (Dufan) merupakan kawasan bermain yang cukup luas. Hingga saat ini Dufan menyediakan peta area dalam bentuk brosur dan standing map yang ada di kawasan bermain. Dengan kemajuan teknologi saat ini sangat mungkin jika Dufan bisa membuat sistem navigasi peta kawasannya dalam bentuk digital. Seperti diketahui saat ini kebiasaan manusia telah banyak berubah, karena itulah sangat besar kemungkinan perpindahan peta dari sistem manual ke digital akan lebih disukai konsumen. Peta bentuk digital karena dianggap lebih praktis dan mudah, apalagi jika berbentuk infografis dinamis. Infografis sendiri merupakan kumpulan informasi dengan bantuan gambar, pengguanaan dinamis dapat diartikan dengan penambahan unsur animasi dalam peta. Menggunakan teknik pengumpulan data berupa observasi langsung dan wawancara. Target penelitian ditujukan bagi para pengunjung Dufan yang meliputi segala usia, mulai dari kalangan pelajar, mahasiswa, dan keluarga dan melalui penelitian ini diharapkan akan diketahui informasi yang apa saja yang diperlukan pengunjung serta media dan desain yang dianggap efisien dan mudah dimengerti, sehingga melalui media peta bisa meningkatkan kepuasan konsumen.
Strategi Kampanye Gubernur Basuki Tjahaja Purnama-Djarot Saiful Hidayat Dalam Menghadapi Pilkada Dki Jakarta 2017
Authors: Nugraha Rahmadya Putra , Puspitasari Anastasya Christy
Published: March 2019

The selection of the 2017 DKI Jakarta governor was attended by 3 candidates, including the pair Agus Harimurti - Sylviana Murni, the pair Basuki Tjahaja Purnama - Djarot Saiful Hidayat and the couple Anies Baswedan - Sandiaga Uno. Basuki Tjahaj Purnama - Djarot Saiful Hidayat is a pair of incumbent governors who again competed in this gubernatorial election. The researcher focused on research to find out how the strategy used by the incumbent governor pair in facing the 2017 DKI Jakarta gubernatorial election. In this case, the author uses the Constructivist paradigm, namely, the truth of a social reality seen as a result of social construction, and the truth of a social reality is relative. The type of research used is descriptive, which describes a social situation as it is by using a qualitative descriptive analysis method. Based on this research regarding the campaign strategy of Basuki Tjahaja Purnama - Djarot Saiful Hidayat in facing the gubernatorial election, the researchers concluded that the pair Basuki Tjahaja Purnama - Djarot Saiful Hidayat possessed and re-demonstrated the real program that was directly felt by the community and also maximized the entire media to socialize their upcoming programs. Pemilihan gubernur DKI Jakarta 2017 diikuti oleh 3 pasangan calon antara lain pasangan Agus Harimurti – Sylviana Murni, Basuki Tjahaja Purnama – Djarot Saiful Hidayat dan Anies Baswedan – Sandiaga Uno. Pasangan Basuki Tjahaj Purnama – Djarot Saiful Hidayat adalah pasangan gubernur petahana yang kembali bersaing dalam pemilihan gubernur ini. Peneliti memfokuskan penelitian untuk mengetahui bagaimana strategi yang digunakan oleh pasangan gubernur petahana dalam menghadapi pemilihan gubernur DKI Jakarta 2017 ini. Dalam hal ini, penulis menggunakan paradigma Konstruktivis yaitu,  kebenaran suatu realitas sosial dilihat sebagai hasil konstruksi sosial, dan kebenaran suatu realitas sosial bersifat relatif.  Tipe penelitian yang digunakan dalam penelitian yaitu deskriptif, yang menggambarkan suatu keadaan sosial secara apa adanya dengan menggunakan metode analisis deskriptif kualitatif. Berdasarkan penelitian ini mengenai strategi kampanye Basuki Tjahaja Purnama – Djarot Saiful Hidayat dalam menghadapi pemilihan gubernur, maka peneliti membuat kesimpulan bahwa pasangan Basuki Tjahaja Purnama - Djarot Saiful Hidayat memiliki dan menunjukkan kembali program nyata yang sudah dirasakan langsung oleh masyarakat dan juga pasangan ini memaksimalkan seluruh media untuk mensosialisasikan program mereka yang akan datang.
Pengaruh Media Sosial Instagram @Zapcoid Terhadap Brand Equity Zap Clinic
Authors: Kinanti Syafira Putri , Putri, S.I.Kom.,M.Si Berlian Primadani Satria
Published: March 2019

Technological development has provided to our generation an easier life in terms of connecting to each other with the blurring boundaries of time and place. According to a survey conducted by wearesocial.com in 2016, 79.0 million out of 88.1 million Internet users in Indonesia are active social media users. Therefore, there has been an increasing number of companies making use of social media to market their products, including ZAP Clinic. Along with the use of social media by ZAP Clinic, the brand equity of the company has become stronger as signified by the company being selected as TOP Brand Award 2016 for the first time. This research aims at understanding to what extent Instagram, as a social media, influences the brand equity of ZAP Clinic, through the company’s Instagram account @zapcoid. This research used quantitative method with explanatory research as its type of research. The data was collected through online questionnaires that were spread via direct messages to Instagram followers of @zapcoid that had done any treament at ZAP Clinic. Sample used in this research amount a hundred. The sampling technique was purposive, while the analysis technique was simple linear regression with the use of Statistical Package for Social Sciences (SPSS). This research demosntrates that social media (X) significantly influences the equity of a brand for 0.621 or 62.1%, while the remnant 37.9% is the contribution of other variables that were not assessed.  Perkembangan teknologi internet di kehidupan manusia mempermudah komunikasi tanpa batas jarak dan waktu. Menurut survei yang dilakukan oleh wearesocial.com pada tahun 2016 dari 88.1 juta pengguna internet di Indonesia 79.0 juta merupakan pengguna aktif media sosial. Oleh karena itu banyak perusahaan yang memanfaatkan media sosial sebagai alat komunikasi pemasarannya, salah satunya adalah ZAP Clinic. Seiring dengan peningkatan kualitas media sosial yang dilakukan, brand equity ZAP Clinic pun semakin kuat yang ditandai oleh terpilihnya ZAP Clinic dalam TOP Brand Award 2016 untuk pertama kalinya. Penelitian ini bertujuan untuk mengetahui seberapa besar pengaruh media sosial instagram @zapcoid terhadap brand equity ZAP Clinic. Metode penelitian yang digunakan adalah metode kuantitatif dengan jenis penelitian explanatory research. Pengumpulan data dalam bentuk kuesioner yang disebar secara online melalui direct message kepada followers akun instagram @zapcoid dan pernah melakukan treatment di ZAP Clinic. Sampel yang digunakan pada penelitian ini berjumlah 100 responden. Teknik sampling yang digunakan adalah purposive sampling. Teknik analisis data menggunakan analisis regresi linear sederhana dan dengan menggunakan aplikasi Statistical Package for Social Sciences (SPSS). Berdasarkan hasil analisis data dapat diketahui bahwa  media sosial (X) berpengaruh signifikan terhadap brand equity sebesar 0,621 atau 62,1%, sedangkan sisanya sebesar 37,9% lainnya merupakan kontribusi variabel lain yang tidak diteliti.
Representasi Maskulinitas Dalam Iklan Televisi Pond’s Men #Lelakimasakini (Analisis Semiotika Roland Barthes Terhadap Representasi Maskulinitas)
Authors: Yuliyanti Friska Dewi , Bajari Atwar , Mulyana Slamet
Published: March 2019

This research aims to know the meaning of denotation, the connotation and the myth or ideology in television commercials POND'S Men that represent the masculine with #LelakiMasaKini edition. The method used in this research is the Semiotic analysis methods. The Semiotic analysis used in this research is the Semiotic Roland Barthes. The results of this research show that there are; meaning denote, the connotation and the myth or ideology in television commercials POND'S #LelakiMasaKini. The results obtained from the signs of the dominant in the preview scenes that are taken in accordance with the criteria that have been determined. Advertising on Rio Dewanto version described three meaning denotes, three meaning of the connotations and three myths. On the version of the advertisement, Keenan Pearce described three meaning denotes, three the meaning of the connotations and three myths or ideologies and on the version of the Marshall Sastra described three meaning denotes, three the meaning of the connotations and 3 myths or ideologies. Concluded the side or the form of masculinity is promoted of the physical appearance of the type of men who tend to metrosexual, the dream of women, the leader success, lack men who think creatively and have hobbies.Penelitian ini bertujuan untuk mengetahui makna denotasi, konotasi serta mitos atau ideologi dalam iklan televisi POND’S Men yang merepresentasikan maskulinitas dengan edisi #LelakiMasaKini. Metode yang digunakan dalam penelitian ini adalah metode analisis semiotik. Analisis Semiotik yang digunakan dalam penelitian ini adalah analisis semiotik Roland Barthes. Hasil dari penelitian ini menunjukkan bahwa terdapat makna denotasi, konotasi serta mitos atau ideologi pada iklan televisi POND’S Men #LelakiMasaKini. Hasil itu diperoleh dari tanda-tanda dominan pada cuplikan adegan-adegan yang diambil sesuai dengan kriteria yang telah ditentukan. Pada iklan versi Rio Dewanto digambarkan 3 makna denotasi, 3 makna konotasi, dan 3 mitos. Pada iklan versi Keenan Pearce digambarkan 3 makna denotasi, 3 makna konotasi dan 3 mitos atau ideologi dan pada versi Marshall Sastra digambarkan 3 makna denotasi, 3 makna konotasi dan 3 mitos atau ideologi. Disimpulkan sisi atau bentuk maskulinitas yang dipromosikan adalah tampilan fisik tipe laki-laki yang cenderung metroseksual, dambaan wanita, pemimpin yang cerdas dengan kesuksesan, lak-laki yang berpikir kreatif dan memiliki hobi.
Pencapaian Brand Corporate Melalui Brand Activation Pendekatan Experiential Marketing (Studi Kasus Laboratorium Klinik)
Authors: Lubis Mahdalena , Ganiem Leila Mona
Published: March 2019

Brand activation is a corporation's endeavor to look deeper into what's in the brand, strategy and position of the brand. A new approach to brand activation by maximizing the range of relevant assets through product and service, employees, identity and communication combined with experiential marketing through sense, feel, think, act, relate, is considered highly effective in achieving corporate brand because it emphasizes the differentiation of competitors. This study aimed to find out how the achievement of corporate brand through brand activation experiential marketing conducted by Clinical Laboratory with the object of PT. Prodia Widyahusada Tbk. This descriptive case study study obtained data through interviews and observations. This research finds the fact that companies do brand activation to achieve corporate brand is holistic to maximize brand in competitive competition, but to create experiential marketing, company can emphasize certain points in accordance with objectives desired by company. At the same time, denial of Schmitt's theory of surprise is the most important, in contrast to that done in the research object that sense and feel are the strongest according to the needs or goals of the company's customers. Utilization of brand activation experiential marketing can create trust, engagement, loyalty, acquisition, share, differentiator with competitors and lead to the achievement of a corporate brand of reputation.berbagai hal yang ada di dalam brand, strategi dan posisi dari brand tersebut. Pendekatan baru terhadap brand activation dengan memaksimalkan berbagai asset yang relevan melalui product and service, employees, identity dan communication dipadu dengan experiential marketing melalui sense, feel, think, act, relate, dinilai sangat efektif untuk mencapai brand corporate karena lebih menekankan differensiasi terhadap kompetitor.  Penelitian ini ditujukan untuk mengetahui bagaimana pencapaian brand corporate melalui brand activation experiential marketing yang dilakukan oleh Laboratorium Klinik dengan objek PT. Prodia Widyahusada Tbk. Penelitian dengan metode studi kasus deskriptif ini memperoleh data melalui wawancara dan pengamatan. Penelitian ini menemukan fakta bahwa perusahaan melakukan brand activation untuk mencapai brand corporate dilakukan secara holistic untuk memaksimalkan brand di persaingan kompetitif, namun untuk menciptakan experiential marketing, perusahaan dapat menekankan poin-poin tertentu sesuai dengan tujuan yang diinginkan oleh perusahaan. Sekaligus bantahan terhadap teori Schmitt yang menyatakan kejutan (think) adalah yang paling penting, berbeda dengan yang dilakukan di objek penelitian bahwa sense dan feel adalah yang paling kuat sesuai dengan kebutuhan atau sasaran pelanggan perusahaan. Pemanfaatan brand activation experiential marketing dapat menciptakan kepercayaan, engagement, loyalitas, akuisisi, share, pembeda dengan kompetitor dan bermuara pada pencapaian brand corporate berupa reputasi.
Diseminasi Informasi Terkait Pariwisata Berwawasan Lingkungan dan Budaya Guna Meningkatkan Daya Tarik Wisatawan (Studi pada Dinas Pariwisata Provinsi Nusa Tenggara Barat)
Authors: Setyanto Yugih , Winduwati Septia
Published: March 2019

Tourism is a huge potential owned by the regions in Indonesia. Many areas in Indonesia that actually has an interesting potential to be developed into tourism object. In order for the potential to have a selling power that attracts potential tourists to come should be disseminated information about the object. The process of information dissemination is adjusted to various things such as the intended audience and what potentials need to be known by the audience. Therefore, each local government has the authority in developing and promoting tourism potential that exists. The local government seeks the promotion of regional tourism potentials through dissemination of information to the public. Roles and functions are carried out so that the potential of tourism areas that are environmentally and culturally relevant tourism can be maximally known by the public and increase the attractiveness of tourists, especially domestic and foreign tourists. Penelitian ini merupakan studi terkait upaya diseminasi informasi di bidang komunikasi pariwisata. Pariwisata merupakan potensi yang sangat besar dimiliki oleh daerah-daerah di Indonesia. Banyak daerah di Indonesia yang sebenarnya memiliki potensi yang menarik untuk dikembangkan menjadi objek pariwisata. Agar potensi tersebut memiliki daya jual yang menarik minat calon wisatawan untuk datang harus dilakukan penyebaran informasi mengenai objek tersebut. Proses diseminasi informasi disesuaikan berbagai hal misalnya khalayak yang dituju dan potensi apa yang perlu diketahui oleh khalayak. Oleh sebab itu, masing-masing pemerintah daerah memiliki otoritas dalam mengembangkan serta mempromosikan potensi wisata yang ada. Pemda mengupayakan promosi potensi wisata daerah melalui diseminasi informasi ke publik. Peran dan fungsi tersebut dilakukan sehingga potensi wisata daerah yakni pariwisata yang berwawasan lingkungan dan budaya bisa secara maksimal dikenal oleh masyarakat dan meningkatkan daya tarik wisatawan, khususnya turis dalam dan luar negeri.
Nilai Eksklusivitas Dalam Karya Foto Cover Majalah Tempo Edisi 4351 Tentang Kasus Bom Sarinah 2016
Authors: Tanjung Yohanes Christiansen , Marta Rustono Farady
Published: March 2019

Visualization towards a news which is not limited on animation or photographic works in electronic media, online, and printed media has purposively been as additional information and becomes a complement of news. Particularly in spot news of the photojournalism works, every occurrence happens quite quickly. Due to photography, every moment can be recorded and well documented, as well as providing answers to what is actually happening on a rapid occurrence. One example is the use of photographs on a printed media, namely Tempo. This Research aims to observe hidden meaning in the works of photojournalism on the cover of Tempo magazine 4351 edition wether it is objective or subjective meaning that be received by the public after seeing the photo on the cover. The method used is descriptive qualitative method by conducting analysis of Peirce semiotics on the cover photo of Tempo magazine issue of 4351. Based on the research which has been done, it can be concluded that the application of visualization conducted by Tempo referred to the works of photojournalism in the cover of Tempo magazine issue of 4351 created exclusivity both in objective and subjective meaning Visualisasi pada suatu pemberitaan baik itu animasi maupun karya foto dalam media elektronik, online, dan pastinya media cetak, mempunyai tujuan sebagai informasi tambahan serta pemanis suatu berita. Khususnya pada karya foto jurnalistik spot news, setiap peristiwa yang terjadi dengan sangat cepat. Oleh karena fotografi, setiap kejadian dapat direkam dan didokumentasikan dengan baik, serta memberikan jawaban atas apa yang sebenarnya terjadi pada suatu peristiwa yang berlangsung dengan cepat. Salah satu contohnya adalah pemakaian karya foto pada sebuah cover media cetak, yaitu Tempo. Penelitian bertujuan untuk mengetahui makna yang tersembunyi dalam karya foto jurnalistik pada cover majalah Tempo edisi 4351 baik berupa makna obyektif maupun subyektif yang diterima publik setelah melihat foto pada cover tersebut. Metode yang dipakai adalah metode kualitatif deskriptif dengan melakukan analisis semiotika Peirce pada foto cover majalah Tempo edisi 4351. Berdasarkan penelitian yang telah dilakukan, dapat disimpulkan bahwa penerapan visualisasi yang dilakukan oleh Tempo mengacu pada karya foto jurnalistik dalam cover majalah Tempo edisi 4351 menciptakan nilai eksklusivitas baik itu dalam makna obyektif maupun subyektif.
DETERMINANTES DOS CUSTOS DE TRANSPORTE DAS EXPORTAÇÕES DO COMPLEXO BRASILEIRO DE SOJA
Authors: Medeiros Rennan Kertlly , Albuquerquemello Vinicius Phillipe , Jesus Diego Pitta , Ramos Hélio Sousa
Published: March 2019

Este trabalho analisa os determinantes dos custos de transporte das exportações do complexo brasileiro de soja, no período 2008-2014, por uma estimação gravitacional com dados em painel. Os dados foram coletados no Commodity Trade Statistics (COMTRADE), da Organização das Nações Unidas (ONU) e desagregados sob classificação Harmonized System (HS).  As estimativas da regressão informaram que para cada quilômetro de distância entre o Brasil e o país importador de soja, os custos se elevam em 6,34%, e uma melhoria de 1% em infraestrutura causa uma redução de 74% nos custos de transporte.
ANÁLISE SOCIAL E ERGONÔMICA DA ATIVIDADE DE COLETA INFORMAL DE MATERIAL RECICLÁVEL
Authors: Musa Carla Fernanda Amaral , Ratzlaff Gabriel , Freitas Adriano Mendonça de , Gloeden Dimas Bortolini
Published: March 2019

A atividade de coletar materiais recicláveis das ruas tem aumentado consideravelmente no Brasil. Por ser uma profissão exercida nas vias urbanas, acaba absorvendo aspectos negativos que inevitavelmente acabam por prejudicar o trabalhador. Além de problemas relacionados à saúde no trabalho, é visível um processo de exclusão dessas pessoas por uma maioria da população. Com isso, o presente artigo tem como objetivo analisar a situação atual desta atividade, apontando suas carências e reais necessidades, a fim de torná-la mais humana. Como ferramentas de pesquisa, foram feitas entrevistas e análises observatórias em diversos locais, constatando-se que estes trabalhadores são prejudicados por problemas não só ergonômicos, mas também sociais, e por isso sugere-se uma abordagem a fim de criar um vínculo entre o catador e a sociedade que o rodeia, para que então se possa também resolver as questões ergonômicas, que acabam sendo secundárias quando os trabalhadores são incluídos em uma sociedade que os exclui.Palavras-chave: Catadores de materiais recicláveis. Ergonomia. Sociedade. Reciclagem. Design social.ABSTRACTThe activity of collecting recyclable materials from the streets has increased considerably in Brazil. Being a profession exercised on the streets it ends up absorbing negatives aspects that inevitably end up harming the worker. In addition to the problems related to work health, a process of exclusion of these people by a majority of the population is visible. Therefore, this article aims to analyze the current situation of this the activity, pointing out its real needs, in order to make it more human. As research tools, interviews and observatory analysis were made in several places, showing that these workers are not only harmed by ergonomic problems but also by social issues, and because of that a different approach is suggested, aiming the development of a bond between the worker and the society around him so the ergonomic issues can be solved, since they end up being secondary when the workers are included in a society that excludes them.Keywords: Recyclable material collectors. Ergonomics. Society. Recycling. Social design.
Uzun Vaka Olarak Sinema Filmlerinin Kullanımına Bir Örnek: The Doctor
Authors: ÖZCAN Müesser , ÇEKİÇ Edip Güvenç , ÖZEL TÜRKCÜ Ümmühani , ELBE Hülya
Published: March 2019

Amaç: Uzun vaka olarak seçilen The Doctor filmi üzerinden klinik öncesi
süreçteki tıp fakültesi öğrencilerinin hasta hekim ilişkisinin olumlu ve
olumsuz yönleri ile ilişkisinin etik boyutu hakkındaki görüşlerini belirlemek
amaçlanmıştır. Gereç ve
yöntem:
Araştırmada filmin
yirmi dördüncü dakikasındaki sahne ile final sahnesi için önceden hazırlanan iki adet
yarı yapılandırılmış sorgulama formu kullanıldı.  Bu sayede öğrencilerin yönlendirilmeden
görüşlerini açıklayabilmesine olanak sağlanmıştır. Bu formlar film izlenirken ilgili
dakikalarda öğrencilere dağıtılarak öğrencilerin konu hakkındaki görüşleri alındı.
Çalışma
gönüllülük bildiren ve filmi izleyip çalışma formunu eksiksiz dolduran
öğrencilerle yürütüldü. Çalışmaya 58 kız, 40 erkek toplam 98 öğrenci
katıldı.Bulgular:
Hasta hekim ilişkisinde hekimin erken tanı koyması, etkin tedavi planı yapması
sergilediği hekimlik bilgi ve becerileri öğrenciler tarafından olumlu yönler
olarak belirlendi. Bununla birlikte hekimin kötü haberi vermedeki başarısızlığı,
empatik yaklaşım sergilememesi, işlemler sürecinde hastaya bilgilendirme yapmaması,
hastayı dinlememesi ve meslektaşına gösterilmesi gereken deontolojik yaklaşımın
sergilememesi gibi tutumlar olumsuz hekim tutumları olarak sıralandı. Kız
öğrenciler erkek öğrencilerden daha fazla oranda; hekimin kötü haberi çok
başarısız verdiği, empatik yaklaşım göstermediği ve meslektaşına uygun
deontolojik yaklaşım sergilemediği görüşündeydi.  Hekim adaylarının hastanın yaşadıklarını
anlayabilmesi için hastanede hasta olarak kalmalarının istendiği sahneye
ilişkin, öğrencilerin
%63,3‘ü böyle bir deneyime gerek olmadığını ve bu becerinin eğitimle
kazanılabilir olduğunu
bildirirmiştir. Bununla birlikte daha önce hastaneye yatış deneyimine
sahip olan öğrenciler hastalığın ve hastaneye yatmanın hastayı anlamaya büyük
katkı sağlayacağı inancındaydı.

Sonuç: Klinik öncesi
süreçteki tıp fakültesi öğrencileri; uzun vaka olarak seçilen filmideki
hikaye üzerinden mesleki bilgi ve becerinin önemi, kötü haberi verme,
empatik yaklaşım sergileme, hasta olan bir meslektaşıyla kuracağı ilişkinin
doğası ve hastalık sürecini deneyerek öğrenme gibi karmaşık etik konular
hakkında görüş bildirebilmişlerdir. Böylelikle
öğrencilerin  iyi bir hekimin sahip
olması gereken temel özellikleri hakkındaki düşüncelerine ilişikin ipuçları da
elde edilebilmiştir.
First Principles Determination of Electronic Excitations Induced by Charged Particles
Authors: Lingerfelt David , Ganesh Panchapakesan , Jakowski Jacek , Sumpter Bobby
Published: March 2019

A time dependent self consistent field based method for determining the rates of electronic excitations induced in materials by the presence of external point charges is presented. The method utilizes the full scalar potential of the external point charge in the interaction Hamiltonian instead of relying on multipolar expansions thereof. A general method is presented for determining the conditions under which dipole selection rules are adequate to describe the electronic response of the material to perturbation by external point charges. The position dependence of point charge induced transition rates between the ground and lowest few excited electronic states was resolved for a small polybenzoid. Notably, electronic excitations that are optically forbidden can be strongly allowed for particular positions of the perturbing point charge. Application of the methods detailed here can lead to an improved understanding of the electronic response of materials under irradiation by beams of charged particles.
XÁC ĐỊNH TỈ LỆ LÝ TƯỞNG CỦA CÁC AXIT AMIN CHỨA LƯU HUỲNH SO VỚI LYSINE TIÊU HÓA HỒI TRÀNG TIÊU CHUẨN CHO LỢN LAI THƯƠNG PHẨM GIAI ĐOẠN 30 – 50kg
Authors: Binh An Dao thi , Thông Hồ Trung
Published: March 2019

Tổng số 72 cá thể lợn có khối lượng trung bình 32,9 kg được sử dụng trong nghiên cứu này. Lợn thí nghiệm được bố trí vào 6 nghiệm thức dựa vào khối lượng bắt đầu thí nghiệm với 6 lần lặp lại mỗi nghiệm thức và 2 con lợn/ô chuồng nuôi (tỉ lệ đực cái 1/1). Tổng số 6 khẩu phần đã được thiết lập trong đó khẩu phần 1-5 có 1,0% SID Lys được cố định là a-xít amin giới hạn 2. Các khẩu phần từ 1-5 có 5 mức tỉ lệ SID SAA:Lys khác nhau (50%, 55%, 60%, 65% và 70%) được tạo ra bằng cách bổ sung DL-Met. Khẩu phần 6 được thiết lập có nồng độ tất cả các loại a-xít amin đủ đáp ứng nhu cầu với 1,11% SID Lys. Kết quả nghiên cứu cho thấy tỉ lệ SID SAA:Lys tối ưu trong khẩu phần có sự khác nhau khi sử dụng các chỉ tiêu nghiên cứu khác nhau và các model thống kê khác nhau. Trung bình cho tất cả các chỉ tiêu nghiên cứu (ADG, G:F, FCR và PUN), tỉ lệ SID SAA:Lys tối ưu cho lợn 30 – 50 kg trong nghiên cứu này là 65,2%. Kết quả này cao hơn một số số liệu được công bố trong thời gian gần đây.Từ khoá: A-xít amin chứa lưu huỳnh, cysteine, lysine, methionine, tỉ lệ tiêu hóa hồi tràng tiêu chuẩn