bluuebunny/crossref_metadata_2025 huggingface dataset:
A versatile nuclei extraction protocol for single nucleus sequencing in non model species – optimization in various Atlantic salmon tissues. v2
Authors: Ruiz Daniels Rose , S Taylor Richard
Published: December 2023

Single cell RNA sequencing has rapidly become a standard tool for profiling transcriptomic diversity across thousands of cells (Linnarsson and Teichmann, 2016), and is now being applied to a large diversity of species and tissues. The main limitation of this technology is that it requires the isolation of live cells from fresh tissue, severely restricting its applicability. As a result, single nuclei RNA sequencing (snRNA-seq), which consists of sequencing the RNA of only the nuclei of cells rather than of the whole cell, has been commonly adopted since it allows samples to be stored for several months prior to processing while yielding comparable results to whole cell sequencing (Kulkarni, et al., 2019; Slyper et al. 2021). A critical challenge for snRNA-seq is the successful extraction of high quality nuclei. This has spurred the recent publication of a number of dissociation protocols for nuclei extraction (Drokhlyansky et al. 2020; Eraslan et al. 2021; Melms et al 2021), however, these have largely been optimized for model species such as humans, and more and more single nuclei is being adopted in non-model species. Here we present a robust protocol that enables the extraction of nuclei from frozen tissue adapted from those shown to work in different tissue types, such as human skin (Drokhlyansky et al. 2020; Eraslan et al. 2021; Melms et al 2021). Our protocol has been used to successfully extract nuclei from an array of different Atlantic salmon (Salmo salar) tissues including liver, skin, fin, spleen, head kidney and gill as well as in other species such as sole (Solea solea) nose and gonad, rabbit (Oryctolagus cuniculus) nasal tissue and nurse shark (Ginglymostoma cirratum) spleen. We present the protocol as applied to fin and skin as these are particularly challenging tissues to work with given their toughness and the presence of hard tissue (e.g., scales and bones), connective tissue and fat deposits. We include notes throughout the protocol so that the reader can optimise it for a variety of tissue types. While the protocol has been optimised to work with the Chromium 10x platform, the most commonly used high throughput microfluidic device, but can be used successfully for the extraction of nuclei for other platforms and applications. The aim of this protocol is to capture 7,000 nuclei per single-nuclei RNA sequencing library using the Chromium Single Cell 3’ Reagent Kits v2 or v3 (10X Genomics). Given its utility for isolating nuclei from difficult to dissociate tissue types, we anticipate that this protocol will be broadly applicable for snRNA-seq of non-model organisms and unconventional tissue types. Thelast stepcontains a supplemental video with extra context and tips, as part of the protocols.io Spotlight series, featuring conversations with protocol authors.
Mouse Perfusions v1
Authors: Zane Asta , J Corbin-Stein Nicole , Childers Gabrielle , Webster Jhodi , Yang Vickie , Won Woong-Jai , Gupta Rajesh , Harms Ashley
Published: December 2023

This protocol outlines the procedure to ethically euthanize/sacrifice a mouse using sterile, cold PBS and paraformaldehyde (4%). Following this perfusion, organs including the brain can be retrieved and fixed for further experiments.
ROTAROD PROTOCOL v1
Authors: Lee Michael
Published: December 2023

This protocol details the rotarod test.
INTRAMUSCULAR PFF INJECTION PROTOCOL v1
Authors: LAB RESEARCH LABORATORY LEE , Lee Michael
Published: December 2023

This protocol details the intramuscular PFF injection procedure.
Análisis de la percepción de los usuarios respecto al proceso de lectura de libros humanos: experiencia de The Human Library en la Biblioteca Nacional del Perú
Authors: Moscoso Carbonel Emilia Hortencia , Quiroz Papa de García Rosalía
Published: December 2023

En la sociedad peruana, la discriminación es una problemática compleja y de larga data que, pese a las normativas vigentes a nivel nacional e internacional, se sigue reproduciendo y legitimando en todos los espacios sociales. Para contrarrestar esta situación, la Biblioteca Nacional del Perú, en el año 2018, autorizó a la organización internacional The Human Library presentar dos actividades de “Biblioteca Humana”, las cuales se sustentaban en la lectura de libros humanos, es decir, en una dinámica de diálogo en la que los libros, en este caso personas voluntarias, comparten con los usuarios sus historias personales con el propósito de desarticular los esquemas socioculturales que fundamentan y legitiman las conductas discriminatorias. El objetivo de la presente investigación fue conocer si estas actividades cumplieron con su finalidad, por lo que se analizaron las percepciones que construyeron los usuarios respecto al proceso de lectura. Para ello, se realizó un estudio cualitativo de carácter descriptivo y se aplicó la teoría fundamentada; además, se privilegiaron algunas contribuciones de los enfoques straussiano y constructivista. Los resultados demuestran que el proceso de lectura contrarresta prejuicios, estereotipos, creencias, ideas y estigmas que contribuyen a perpetuar y asegurar prácticas discriminatorias.
IMPACTO DA FOTOBIOMODULAÇÃO NA HIPOSSALIVAÇÃO INDUZIDA POR RADIOTERAPIA: REVISÃO INTEGRATIVA DA LITERATURA
Authors: Alana de Souza Maria , CLAUDINO GOMES AMANDA , Carvalho De Figueirêdo Leitão Paulo Kledson , Da Silva Barbosa Jussara , De Medeiros Martins Yuri Victor , Bandeira de Pontes Santos Hellen
Published: December 2023

A hipossalivação é muito comum nos pacientes que são submetidos ao tratamento de radioterapia contra o câncer de cabeça e pescoço, pois, na grande maioria das vezes, as glândulas salivares estão dentro do campo de radiação, com isso sofrem danos que, dependendo da dose e da intensidade, são considerados reversíveis. A fotobiomodulação tem sido muito utilizada para o tratamento das disfunções das glândulas salivares, por ter uma ação eficaz na estimulação do fluxo salivar, aumentando a taxa de proteína na glândula parótida, modulando os sistemas antioxidantes, estabelecendo o manejo glicêmico nas glândulas salivares. Isso reduz a concentração de lipídios nestes tecidos e aumentando a reprodução de células mioepiteliais. Diante do exposto, o presente estudo tem o objetivo de realizar uma revisão integrativa da literatura sobre os efeitos da fotobiomodulação em pacientes com hipossalivação induzida por radioterapia. Foi realizada uma busca eletrônica nas bases de dados PubMed e Lilacs. Foram adotados como critérios de inclusão: a) estudos que envolvessem indivíduos que estavam sob tratamento oncológico com radioterapia que apresentassem hipossalivação e tivessem realizado a fotobiomodulação e, b) artigos nos idiomas português, inglês e espanhol. Como critérios de exclusão: a) trabalhos que envolviam indivíduos não submetidos à tratamento radioterápico e que apresentaram hipossalivação relacionada a qualquer outro fator não oncológico, e b) estudos in vitro. De acordo com a literatura consultada, podemos concluir que o uso da fotobiomodulação consegue reduzir o índice de hipossalivação e xerostomia induzida pela radiação emitida durante o tratamento de câncer de cabeça e pescoço.
Geología y Arqueología del Terremoto-Tsunami de finales del Siglo IV a.C. que destruyó la ciudad Romana de Baelo Claudia (Cádiz, Sur España)
Authors: Silva Barroso Pablo Gabriel , Reicherter Klaus , García-Jiménez Iván , Prados-Martínez Fernando , Pérez-Tarruella Javier , Sánchez-Sánchez Yolanda
Published: December 2023

El presente trabajo resume el conjunto de nuevas investigaciones geológicas y arqueológicas que certifican la ocurrencia de un potente evento terremoto-tsunami que devastó la antigua ciudad romana de Baelo Claudia (Estrecho de Gibraltar) en la segunda mitad del siglo IV d.C. Aparte de las importantes deformaciones cosísmicas documentadas en forma de deformaciones en los restos arquitectónicos (EAEs) el presente estudio se centra en los efectos y registro sedimentario del tsunami que acompaño al terremoto. El análisis de los depósitos de tsunami en sondeos y afloramientos de la parte baja de la ciudad indican que este alcanzó una altura mínima de + 8m por encima del nivel del mar y que penetró al menos 250 m hacia el interior alcanzando la base de los templos en la zona del Foro. Sin embargo, en los pequeños arroyos que se encuentran en la zona y en la antigua laguna litoral oriental la inundación pudo penetrar hasta algo más de un kilómetro. La capa del tsunami ha sido bien documentada dentro y fuera de la ciudad en trabajos anteriores y se encuentra bien. La tsunamita es un depósito arenoso cohesivo oscuro (de 28 a 52 cm de grosor) que contiene fragmentos de cerámica, huesos de pescado y de animales, cristalería, ladrillos y grandes bloques de mampostería y tambores de columnas. La capa también contiene conjuntos microfaunísticos con una mezcla de foraminíferos bentónicos y planctónicos, así como gasterópodos lagunares de agua salobre y numerosos restos de conchas y foraminíferos rotos reelaborados. Los datos presentados en este trabajo indican que la capa del paleotsunami se compone principalmente de arenas finas-medias bien redondeadas procedentes de la reelaboración de depósitos eólicos y de las antiguas playas y barras litorales que en época romana cerraban la antigua bahía. Interpretamos que la mayoría de los depósitos de tsunami son depósitos de backwash (retroceso de la ola) que quedaron atrapados entre las ruinas de la ciudad y especialmente a lo largo del Decumano Máximo, Termas marítimas y Mausoleo de Iunia Rufina en la necrópolis oriental de la ciudad. Los hallazgos arqueológicos en este monumento derribado por el terremoto y posterior tsunami permiten establecer la edad de este suceso entre los años 350 – 390 AD.
Palabras clave: Arqueosismología, Efectos Arqueológicos de los Terremotos (EAEs), Tsunamita, Baelo Claudia, Estrecho de Gibraltar, Sur de España.
Analysis of Uzbek Equivalents of English Business Terms
Authors: Elyorjon Odiljonovich Hasanov
Published: December 2023

The following article illustrates terminology and its importance in linguistics as terminology is one of the key factors of linguistics as well as lexicology. Moreover, the article shows some analysis of business terms and their usage in two different languages, Uzbek and English.
Interaction of Language Units. Syntagmatic, Paradigmatic and Hierarchical Relations
Authors: Zulayxo Shamshidinovna Jo‘rayeva , Muslimaxon Aliqo'ziyeva , Sevinch Shokirjonova , Saodatxon Ikromova , Hilola Abdugafforova
Published: December 2023

The article illustrates some language units and interactions between them. Moreover, it researchs syntagmatic, paradigmatic and hierarchical relations in linguistics.
A Review on Food Wastes for Manufacturing New Food Products
Authors: Samapti Bedi  , 2Souvik Tewari  , Bidyut Bandhopadhyay  , Prathiksa Pramanik
Published: December 2023

Food waste utilisation is the very current global concern at today’s world. Fruits and vegetables are the foremost part of balanced diet. The cycle of healthy diet is not fulfilled without fruits. Furthermore, fruit peels possess also great benefits for people health. Researcher are trying to make new food products from different food wastes. From recent research study it was found that pomegranate peels, mango peels, orange peels, banana peels which contribute enormous good efficacy to provide good health status. These waste constituent help to develop different new fortified food products, which contain lots of bioactive compounds that helps to mitigate acute to chronic ailments. This review article will be discussed an up-to-date information about uses of food wastes for manufacturing new fortified food products.
Absenteísmo e hábitos de vida: fatores que atrasam o diagnóstico do câncer testicular
Authors: Lugli Gabriel da Silva , Fontes Maria Fernanda Mendonça , Kanzler Bruno , Rudolpho Carlos Miguel , Ismael Travessini Leme Vinicius , Pinto Luciano Henrique
Published: December 2023

Estudos mostram maior mortalidade em homens que em mulheres ao se tratar de neoplasias, sendo o câncer testicular (CT) o tumor sólido mais comum em homens de 18 a 39 anos. Este trabalho aborda aspectos relativos à identificação e diagnóstico do CT que afetam a qualidade de vida masculina, associados à hábitos diários e absenteísmo. A pesquisa de revisão foi realizada em 5 etapas: (Fase I) incluir a definição da pergunta de pesquisa obtida via acrônimo PICO; (Fase II) esquema booleano; (Fase III) definição sitios de busca; (Fase IV) seleção dos artigos; (Fase V) análise dos resultados obtidos. Desta amostra de artigos, evidenciou-se um aumento na incidência nas últimas décadas, principalmente devido à exposição a interferentes endócrinos e o absenteísmo, notando uma maior prevalência na raça caucasiana, mas não apresentando aumento dos casos com o aumento da idade. Conclusão: Portanto, torna-se claro que medidas podem ser tomadas nos casos em que a prevenção seja uma forma de prevenir o acometimento da neoplasia, através de políticas os quais podem aumentar a transmissão da informação para o público masculino, possibilitando, assim, a conscientização do autocuidado.
Signalized and Unsignalized Road Traffic Intersection Models: A Comprehensive Benchmark Analysis
Authors: Ba Ibrahima , Tordeux Antoine
Published: December 2023

Road traffic flow models allow the development and testing of intelligent transportation solutions. Macroscopic intersection models are especially relevant for the simulation of large traffic networks. In this article, we study four first-order signalized and unsignalized intersection models. The two unsignalized approaches are the first-in-first-out (FIFO) model (roundabout-type intersection) and an optimal non-FIFO model (highway-type intersection). The optimal control operates upstream for the first signalized intersection model. It occurs downstream for the second signalized model. All four models satisfy the expected physical constraints of vehicle conservation, traffic demand, and assignment. The models are minimal and allow a comprehensible analysis of the results. We determine mathematical relationships between the intersection models and empirically analyze the performances using Monte Carlo simulations. The numerical simulations assume random demand, supply, and assignment. Besides average performances, the approach accounts for the flow ranges of variation. A benchmark analysis compares the intersection models. We observe that the optimal signalized intersection models overcome the performances of the FIFO model in congested states. They may even reach the performances of the idealistic non-FIFO model. Further applications for the four intersection models are discussed.
Effects of Companion Animals Interaction on Adolescents Social Withdrawal Focusing on the Mediating Effect of Smartphone Overdependence
Authors:   Research Institute For Life And Culture Sogang University, Lee Jung In
Published: December 2023

The purpose of this study was to examine the mediating effects of smartphone overdependence on the effects of companion animal interactions on adolescents’ social withdrawal. For this purpose, an online survey was conducted among junior high school and high school students aged 14~18 years through an online research company from February 16 to February 27, 2023, consisting of a total of 375 data were used for analysis. The mediating effects were analyzed using a structural equation model, and the statistical significance of the mediating effect was verified by applying the bootstrapping method. The main findings of the research are as follows. First, the companion animal interaction showed a statistically significant direct effect on adolescents’ smartphone overdependence and social withdrawal. Second, the companion animal interaction had a statistically significant direct effect on social withdrawal by mediating smartphone overdependence. In this process, a partial mediating effect was confirmed. Third, smartphone overdependence showed a statistically significant direct effect on social withdrawal. This study confirmed that interaction with companion animals is a factor that affects adolescents’ smartphone overdependence and social withdrawal. Based on these results, intervention plans to prevent adolescents’ smartphone overdependence and social withdrawal were discussed.
A Study on the Causes of Suicidal Ideation in Alcoholics: Exploring the Internal Factors of Hopelessness
Authors:   Research Institute For Life And Culture Sogang University, Kang Jun Hyeok , Kang Sun Kyung , Maeng Seong Jun
Published: December 2023

The purpose of this study is to explore the internal factors that contribute to suicidal ideation in alcoholics. To fulfill the purpose of the study, cases of alcoholics with suicidal thoughts and attempts were collected. The cases were extracted from memoirs published by A.A. Korea, and a total of 23 cases with specific experiences related to alcoholism and suicide were selected. The collected data was analyzed using a qualitative case study method. The analysis showed that alcoholics experienced health problems, economic problems, and relationship problems due to their drinking, which led to internal distress such as loneliness, pessimism about their health, lethargy about alcohol, self-blame, others' blame, and self-pity. The end result of this internal distress is loss of hope (despair). The alcoholics' expressions of hopelessness included contents of suicide. Based on these findings, the researchers suggest several practice and policy implications.
A TOPIC MODELING BASED BIBLIOMETRIC EXPLORATION OF TOP-3 JOURNALS IN MANAGEMENT INFORMATION SYSTEMS
Authors: Parlina Anne , Kusumarani Riri
Published: December 2023

A management information system (MIS) is a system that manages, processes, and presents information to management that aims to improve the quality of decisions and policies. A common misconception regarding the management information system (MIS) topic is that it mainly involves programming. This study aims to capture the intellectual structure and theme evolution of MIS by incorporating latent dirichlet allocation (LDA) into its methodology. A bibliometric analysis was conducted to evaluate the publication characteristics of the top three MIS journals (IJIM, JSIS, and MIS Quarterly: Management Information Systems) from the SCOPUS database between 1980 and 2021. Our findings indicate the trend of publishing articles, the structure of science, and the topics that stand out in the top three journals.
Lost on the Way: “The Walking Man” by Alberto Giacometti and Its Recontextualization by Piotr Stepnowski as a Metaphor for the Human Condition
Authors: Tomaszewska Grażyna B.
Published: December 2023

The main idea of the article is Henry David Thoreau’s conviction that being lost on the way, losing one’s way and, consequently, coming to a stop enables one to truly explore the present location and to establish the destination one wishes to reach. This perspective allows to observe the situation of a modern man and pose questions related to their actions to date. The interpretative material through which these problems are realized are two contemporary sculptures, treated as metaphors of the human condition: Albert Giacometti’s Walking Man and Piotr Stepnowski’s Walking Man (a form of recontextualization of Giacometti’s sculpture).
On the Benefits of Posthuman Research for Polish Language Teaching
Authors: Wróblewski Maciej
Published: December 2023

The aim of the article is to present a new tendency of humanities (transhumanism, posthumanism, new materialism) in the educational context. In the first part, the relationships between Polish language teaching in primary and secondary schools and literary studies are characterized in historical order. The school and university cooperation allows to conserve suitable impact on the pupils’ knowledge, skills, and their moral attitude to contemporary reality. Scientific support of school curricula is today very urgent because we are living in a chaotic reality that Zygmunt Bauman called liquid modernity. The classical patterns of knowledge and authority have been disappearing for dozens of decades. Moreover, we live in “a realm” of big data, rapid processes of digitalization, and a plethora of information. The second part of the article relates to different subjects of anthropology of literature, first of all transhumanism, posthumanism, and new materialism, which allow us to demonstrate the human condition in a new light. A teacher, using the tools of the new humanities, while reading literary texts, can indicate the natural relationships between man and the natural environment: plants, animals, terrain, climate.
Quiet, Distant, Closed… On Experiencing Friendship by Sixth Graders during a Pandemic
Authors: Groenwald Maria
Published: December 2023

The issue presented in the study is the experience of friendship by sixth-graders during the pandemic and in the period preceding it. Considering these issues, they were used for statements from several sources, formulated by: Aristotle and published in his works, students taking the test after the sixth grade in 2007, and 13-year-olds learning remotely or in a hybrid way due to the pandemic. The analysis of the obtained empirical data makes it possible to identify: changes that have occurred in the students’ experience of friendship; different temporal perspectives in perceiving friendship; differences in the description of the characteristics of a friend.
Covid Buzzwords in Youth Language
Authors: Wlazły Agnieszka
Published: December 2023

The article concerns new buzzwords created in the “time of the epidemic”. What inspired this research was the COVID-19 pandemic which has left its mark on many aspects of human life. The aim of the research, based on the diagnostic survey method, was to answer two questions: (1) Do you know any pejorative (negative) expressions connected to epidemics (e.g. the plague, cholera, typhoid fever, the Spanish flu) experienced by humanity? If so, then provide examples of such expressions; (2) In your opinion, can the COVID-19 pandemic leave a mark on our language? Have you already encountered any expressions related to the coronavirus pandemic in everyday communication? The research was carried out on a group of 100 secondary school and university students. The expressions listed by those surveyed in the questionnaires allowed the author to create a typology thereof. It turned out that university students proved to be more creative in comparison with their younger counterparts. This might be due to their age, education level, and out-of-school interests of the respondents.
Solidarity, Community and Ethics in the Context of Engaged Humanities (Contemporary Historical Novels for Young Readers as Examples of Cause Literature)
Authors: Michułka Dorota
Published: December 2023

The purpose of the article is to analyze and interpret contemporary Polish novels for young people that portray the image of the People’s Republic of Poland. These works provoke young readers to discuss historical issues and help build historical awareness and social memory. The times of Solidarity, the period of martial law and – in a broader context – the social and moral realities of the communist era as literary subjects are excellent examples of this. Literary “provocations” and controversial evaluation of events in the books discussed in this text are often realized through narrative challenges, such as “private” narratives (micro-stories) modeled on stories of family life, strengthening the understanding of the culture of memory (collective and individual), the perspective of a child/teenage protagonist, the unconventionality and innovation of the authors’ artistic creation, the strength of which are political allusions and elements of historical politics recognizable at a deeper level of meaning. Treated as literary endeavors (e.g., from the perspective of the poetics of everyday life exposing the phenomena of modus vivendi and modus adaptandi), they create in the stories a platform for discussion about solidarity and community of action by audiences of different ages, provoking difficult intergenerational dialogue and reflection on martial law or – more broadly – the communist period.
Spaces of Indifference: Literature and Education against Contempt
Authors: Janus-Sitarz Anna
Published: December 2023

The article describes important aspects of life that are overlooked in Polish language education: obsolescence, intellectual disability, poverty, and pro-environmental activism. Each of these aspects becomes a reason for exclusion, a pretext for showing contempt. The literature for children and young adults opposes the signs of marginalization of these phenomena. The author reflects on the potential of literary works and the duties of Polish language education in creating an inclusive society and an inclusive school that supports each student and teaches dialogue and problem-solving.
Poets and Literature Experts: On the Educational Value Dialogues of Czesław Miłosz and Tomas Venclova, as well as of Tadeusz Różewicz and Karl Dedecius
Authors: Łazarska Danuta
Published: December 2023

Dialogues between poets and literature experts, including translators, may relate to a number of matters. Not infrequently, these are problematic topics stored in the memory and associated with difficult relations between nations, as well as with the search for ways to discover and build a literary and cultural community and a bridge based on understanding between people of different nationalities. The aim of the article is to focus attention on selected, not always easy, dialogues between Czesław Miłosz and Tomas Venclova, Tadeusz Różewicz and Karl Dedecius. Both the subject matter of the written exchange of ideas that takes place between them, and the ways in which the conversations/discussions are conducted, open up many important issues. The latter involves the broadly understood value of these dialogues both for writers and experts on their works and for contemporary readers – high school students.
On Didactics and the Benefits of a Certain Dangerous Skill
Authors: Kwiatkowska-Ratajczak Maria
Published: December 2023

The review draft outlines problem analyses of various contemporary cultural texts and old-time writings, forming our collective memory, published in the book Literatura grozi myśleniem (Literature May Make You Think) by Piotr Kołodziej. As the author argues, educational issues described by Kołodziej may interest not only teachers and academic methodologists. The didactic model presented by the researcher from Kraków is worth exploring by both students and representatives of diverse disciplines of Polish studies since Kołodziej shows what good methodology is, and consequently what good school – which educates young people humanistically – can be valued.
Pengaruh pengalaman mengajar guru SMP terhadap keterampilan bertanya tingkat dasar dan lanjut
Authors: Asyarifah Runing Fikriyah , Mardiani Sella , Anggraini Shinta Dea , Gafia Syamsudin , Faillah Udi , Puteri Yuditha Oktaviane , Soekamto Hadi
Published: December 2023

One of the basic teaching skills that is important for a teacher to have is the skill of asking questions. Questioning skills are one of the basic teaching skills that are very important in the process of implementing learning. Questioning skills are divided into two, namely basic level questioning skills and advanced questioning skills. The skill of asking questions has several purposes, including generating motivation, arousing interest and curiosity, focusing attention, training and improving questioning skills, diagnosing the level of learning difficulties, measuring the level of student understanding, and developing how students learn actively and productively. This study aimed to determine the effect of junior high school teachers' teaching experience on basic and advanced questioning skills. This research uses the type of ex post facto research. Data collection techniques in the form of observation, interviews, and documentation. Source of data used in the form of primary and secondary data. The data analysis technique is descriptive statistical analysis in the form of normality tests and regression tests. The results of this study are that the variable does not significantly affect the questioning skills variable.

Salah satu keterampilan dasar mengajar yang penting dimiliki oleh seorang guru adalah keterampilan bertanya. Keterampilan bertanya merupakan salah satu keterampilan dasar mengajar yang sangat penting dalam proses pelaksanaan pembelajaran. Keterampilan bertanya dibagi menjadi dua yaitu keterampilan bertanya tingkat dasar dan keterampilan bertanya tingkat lanjut. Keterampilan bertanya memiliki beberapa tujuan antara lain yaitu menimbulkan motivasi, membangkitkan minat dan rasa ingin tahu, memusatkan perhatian, melatih dan meningkatkan keterampilan bertanya, mendiagnosis tingkat kesulitan belajar, mengukur tingkat pemahaman siswa, dan mengembangkan cara siswa belajar aktif dan produktif. Tujuan dari penelitian ini yaitu untuk mengetahui pengaruh pengalaman mengajar guru SMP terhadap keterampilan bertanya tingkat dasar dan lanjut. Penelitian ini menggunakan jenis penelitian ex post facto. Teknik pengumpulan data berupa observasi, wawancara, dan dokumentasi. Sumber data yang digunakan berupa data primer dan sekunder. Teknik analisis data yaitu analisis statistic deskriptif berupa uji normalitas dan uji regresi. Hasil penelitian ini yaitu variabel tidak memberikan pengaruh signifikan terhadap variabel keterampilan bertanya.
La carta de dote de Ana Félix de Guzmán: una aproximación a los bienes suntuarios de los II marqueses de Camarasa
Authors: Ortega Jiménez José Manuel
Published: December 2023

En este artículo se pretende estudiar el conjunto de joyas, vestidos, plata labrada y otras piezas interesantes que se tasan en la carta de dote de Ana Félix de Guzmán, hija de los primeros condes de Olivares, con motivo de su matrimonio en 1568 con Francisco Miguel de los Cobos, heredero de los marqueses de Camarasa. Con este análisis daremos a conocer parte del patrimonio suntuario de los II marqueses de Camarasa, una de las familias más importantes de la Edad Moderna.
Güell Pavilions of Antoni Gaudí as an example of new mythology
Authors: Rius Carles
Published: December 2023

The Güell Pavilions are known for being the first work that Antoni Gaudí built for the person that would become his main patron, Eusebi Güell. For years, these buildings have been considered to have some functional roles, and to contain some sporadic references to the L’Atlàntida, a poem written by Jacint Verdaguer. In this paper, however, I will argue that this work of Gaudí is more than this, since L’Atlàntida was already a good example of the idea of a new mythology, and Gaudí intertwined these literary references with “aesthetic geometry”, which had been reconstructed by the German artist Peter Lenz. I will show where and how this geometry is present in the Güell Pavilions. As a result, these buildings will reveal as an organic work, and a good example of the idea of a new mythology applied to plastic arts.
El panteón familiar del señorío de Serranos de la Torre (Ávila)
Authors: Mont Muñoz Ismael
Published: December 2023

En la iglesia del antiguo señorío de Serranos de la Torre (Zapardiel de la Cañada, Ávila) se construyó en la transición del siglo XV al XVI una capilla funeraria destinada a convertirse en lugar de enterramiento del linaje de los Barrientos. En ella se erigió el monumento fúnebre de Bernaldino de Barrientos, III señor de Serranos de la Torre. El sepulcro, creado por Vasco de la Zarza, constituye una de las más tempranas aplicaciones del lenguaje renacentista en la escultura funeraria de la provincia de Ávila. En este artículo estudiaremos la iglesia del señorío, el sepulcro, así como algunos aspectos fundamentales sobre la biografía de sus promotores y el contexto histórico y artístico en el que se enmarca el proyecto.
Os núcleos de sepulturas a norte da muralha romana de Braga
Authors: Braga Cristina Vilas Boas
Published: December 2023

O espaço de enterramento localizado a norte da cidade romana de Braga, genericamente designado de necrópole do Campo da Vinha, corresponde a um espaço funerário do qual pouco se conhece. Apesar de referenciado, desde 1594, no mapa de Braga de Georg Braun, apenas eram, até recentemente, conhecidos alguns achados de cariz funerário, como estelas funerárias, recolhidas em circunstâncias desconhecidas, em meados do séc. XX. Não obstante, a identificação de um novo núcleo de sepulturas na rua Abade da Loureira, em 2015, ainda que num contexto de emergência e salvamento, lançou uma série de novas pistas relativas à organização e extensão das necrópoles urbanas, principalmente, daquela que se localizava na zona setentrional da cidade romana e tardo-antiga. Com este trabalho, pretendemos apresentar os novos dados relativos às particularidades topográficas, organização, distintas estratégias de uso e ocupação do espaço funerário referido e o espólio recuperado.
Seguimiento a los egresados de la Maestría en Nutrición Humana
Authors: Machaín Vega Gustavo , Pineda Ozuna María Gisela
Published: December 2023

Introducción: Diferentes estudios de seguimiento de egresados hablan del valor de obtener información sobre las actividades profesionales que ejercen y determinar el impacto de la formación recibida y la percepción de la misma. Objetivos: Determinar el desempeño de los egresados de la Maestría en Nutrición Humana FCM- UNA de las promociones del 2007 al 2020. Materiales y métodos: Estudio descriptivo de diseño observacional con enfoque cuantitativo que obtuvo la participación de 83 de los 91 egresados que completaron la encuesta enviada a través del Formulario Google. Resultados: Entre los más resaltantes se tiene que las egresadas entre los encuestados sobresalen las mujeres (90,4 %). El área laboral ejercida; mayor cantidad en el área clínica (61,4 %), consultorio (24,1 %), salud pública en un 6%. El 55,4 % respondió que tuvo más oportunidades laborales; solo el 28,9 % realiza tutoría de tesis. El 79,1 % ha mejorado sus actividades docentes o asistenciales y el 55,4 % ha respondido que no desempeña actividad docente. El 71,1 % ha colaborado en trabajos de investigación siendo magister, en área clínica (47%), en Salud Pública (14,5 %), en área de alimentación, (6%), otros (3.6%); el 64,9 % no ha publicado el trabajo de investigación de la maestría realizada. El 95,2 % no ha hecho aún el Doctorado en Nutrición y al 89,2 % le gustaría hacerlo. Un 87,9 % califica la Maestría de Nutrición Humana FCM-UNA de Excelente o Muy Bueno. Conclusión: Se identifica una mayor cantidad de egresadas mujeres, en cuanto al campo laboral de desempeño, existe una mayor cantidad en el área clínica, más de la mitad de los egresados ha participado en un trabajo de investigación siendo magister en el área clínica, la tesis de maestría no ha sido publicada por la mayoría. Casi el total no ha realizado un Doctorado en Nutrición. Se presenta por primera vez, a nivel nacional, un estudio sobre el desarrollo profesional de los egresados de la Maestría en Nutrición Humana que podría ser útil para futuros trabajos de investigación y toma de decisiones en formación continua.
Impacto económico de desbridamientos quirúrgicos y amputaciones de miembros inferiores en pacientes diabéticos
Authors: Colucci Alexandra , Giubi Jorge
Published: December 2023

Introducción: La diabetes mellitus tipo 2 (DM2) constituye un problema de salud pública. Objetivos: Determinar la frecuencia de los desbridamientos quirúrgicos y amputaciones de miembros inferiores en pacientes diabéticos tipo 2 y su impacto económico. Materiales y métodos: Se realizó un estudio Observacional descriptivo de corte transversal. Se estimaron los costos médicos directos tanto de desbridamientos quirúrgicos como de amputaciones de miembros inferiores en pacientes diabéticos en el Hospital de Clínicas San Lorenzo, durante el año 2019. Resultados: El total de desbridamientos quirúrgicos y amputaciones de miembros inferiores en el año 2019 representan el 1,9% (314/16.484) de los procedimientos quirúrgicos realizados en el Hospital de Clínicas. El monto total de gastos es de 1.804.185.116 (262.541 USD), de los cuales 172.514.000 (38.857 USD) constituyen gastos de bolsillo y 1.631.671.116 (237.437 USD) constituyen gastos erogados al Estado Paraguayo a través del Hospital de Clínicas de San Lorenzo. Conclusión: Las complicaciones de la diabetes imponen considerables costos tanto en el gasto de bolsillo, al sector de la salud como a la economía en general en el Paraguay, por lo que es necesario re evaluar el manejo de esta problemática teniendo en cuenta el gran impacto que tienen dichos procedimientos producen en la vida de los pacientes a nivel físico, emocional, familiar y social, así como la carga económica que conlleva el tratamiento para el Sistema de Salud.
Abdomen agudo por torsión de epiplón mayor simulando una apendicitis aguda
Authors: Rodríguez González Agustín , Segovia Lohse Herald René , Zárate Centurión Darío , Arzamendia Marina
Published: December 2023

La torsión del epiplón mayor es una patología poco frecuente con una clínica inespecífica, por lo que históricamente su diagnóstico es realizado en el quirófano ya que simula patologías como la apendicitis o colecistitis. Los métodos auxiliares de diagnóstico como las ecografías o las tomografías son de mucha utilidad para la sospecha de esta patología, aunque no cuenta con signos patognomónicos de la enfermedad, las imágenes asociadas a la clínica del paciente pueden llevar a un diagnóstico preciso. Presentamos el caso de un paciente joven de sexo masculino, que acudió al servicio de urgencias por cuadro de dolor abdominal tipo cólico de moderada intensidad en fosa iliaca derecha, acompañado de sensación febril, sin alteración de la analítica sanguínea, sin hallazgo de valor en la ecografía abdominal, que ante la persistencia del dolor y la fiebre se realizó una tomografía contrastada en la que se observó un empastamiento del epiplón sometiéndose a una laparoscopía exploradora con el hallazgo de una torsión del epiplón mayor.
Formando médicos para el siglo XXI: El rol crucial de la educación basada en competencias
Authors: Ramos Zaga Fernando
Published: December 2023

A lo largo de la historia, el campo de la medicina se ha adaptado a las necesidades cambiantes de la sociedad y del sistema sanitario. Ante esa situación, surge la necesidad de plantear la transformación de la formación médica mediante un enfoque basado en las competencias y así definir el perfil de un médico para el siglo XXI. El presente artículo tiene por objetivo analizar y describir el rol de la formación basada en competencias en la formación médica en la preparación de los estudiantes de medicina. Para tal fin, se ha llevado a cabo una exhaustiva revisión bibliográfica en la que se analizan los conceptos clave de la formación médica basada en competencias. Los resultados destacan la importancia de integrar el desarrollo de habilidades en la formación médica teniendo en cuenta los factores sociales y culturales, así como fomentar la reflexión crítica en la formación médica. Se concluye que la educación médica debe adaptarse a las demandas cambiantes del campo, con la participación de diversas partes interesadas y la evolución de los métodos de enseñanza.
The Importance of Preventing and Managing Tear Dysfunction Syndrome in Allergic Conjunctivitis and How to Tackle This Problem
Authors: Montero-Iruzubieta J , Sanchez Hernandez MC , Dávila I , Leceta A
Published: December 2023

Tear dysfunction syndrome, also known as dry eye disease (DED), is a multifactorial disease of the ocular surface characterized by the loss of tear film homeostasis. DED shows a significant clinical overlap with ocular allergy (OA), which alters tear film homeostasis, thus predisposing the patient to DED. Both conditions constitute the most common ocular surface disorders and have a potentially severe impact on patients’ quality of life. Clinical practice guidelines recommend topical therapies as first-line treatment for OA. However, eye drop formulations may contain additional substances that can contribute to ocular surface damage and the development of DED. Therefore, physicians treating ocular allergy should be aware of problems affecting the tear film, the role of tear film disruption in OA, and topical treatment to prevent or minimize DED. The aim of this review is to present an updated overview of the topic.
Comparison of Cephalometric Measurements Between Hand Tracing and Digital Tracing Based on Android OneCeph
Authors: Utari Tita Ratya , Mujidah Nur Izzatul
Published: December 2023

Lateral cephalometric radiographic examination is one of the supporting examinations in orthodontic treatment. Cephalometric measurements can be performed using hand tracing (manual) and digital methods. The digital method is widely preferred today due to its faster measurement, easy and safe storage, and can be sent anywhere easily. One of the applications that can be utilized for digital analysis is OneCeph. This application’s accuracy for cephalometric analysis, therefore, needs to be evaluated. This study aims to determine the differences in cephalometric measurements using the Ricketts method between hand tracing and digital tracing based on the OneCeph Android application. This analytic observational study utilized a cross-sectional design conducted at the Dental Hospital of UMY. The samples were 30 lateral cephalometric radiographs of good quality and had film negatives and digital files. The Ricketts method analysis was carried out manually and digitally utilizing the OneCeph application. The Shapiro Wilk test results showed that the data were normally distributed for all components except for the convexity of point A, lower incisor to A Pog line, and e-line. Comparative test results with independent sample t-test and Mann-Whitney test demonstrated no significant difference in all components (p0.05), except for the variable lower incisor to A Pog line (p0.05). The multivariate analysis results also showed p0.05, demonstrating no significant difference for all components (p0.05). The OneCeph application is no different from the gold standard (hand tracing/manual method) that has been used so far, so it can be an alternative for cephalometric tracing.
Unlocking oral submucous fibrosis: From origin to interventions
Authors: Pandey Kanu , Dubey Vertika , Bhargava M Vivek , Peswani Khushboo Chhabaria , Khan Shahabuddin , Bhatt Drishti
Published: December 2023

This article explores the conundrum of biofilm formation in orthodontics, its impact on oral health, and the role of the bonding procedure. Biofilms are resilient structures formed through stages like attachment, adhesion, growth, and maturation, with the extracellular matrix (EPS) playing a vital role. The bonding procedure unintentionally creates surfaces where bacteria thrive, leading to biofilm development. Factors like oral hygiene, diet, and bracket design influence biofilm formation. Maintaining oral hygiene during orthodontic treatment can be challenging due to food trapping and cleaning difficulties. Strategies to minimize biofilms involve patient education, improved bonding techniques, and antimicrobial agents. Biofilms can lead to dental decay, gingivitis, periodontitis, and white spot lesions. Combating biofilms requires collaboration, patient education, and ongoing research. Improved management can lead to better oral health outcomes for orthodontic patients.
Conservative management of a 3 months long standing bilateral temporomandibular joint dislocation: A case report
Authors: Gupta Gaurav , Gupta D.K. , Gupta Neelja , Chandra Neeraj , Sankhla Devanshi
Published: December 2023

Temporomandibular joint (TMJ) dislocation is a type of condition where the condyle is anteriorly displaced beyond the articular eminence. Long standing cases with TMJ dislocation condition persisting for more than a month becomes challenging to treat. Its management includes closed reduction to complicated surgical procedures so as to reduce the dislocated condyles. Mandibular dislocation cases present with its own distinctive features. The aim of the report is to reduce the dislocated condyles through conservative management.

This paper presents with non-invasive and conservative method for management of a long standing case (three months old) of TMJ dislocation in patient with acute renal failure and uncontrolled diabetes giving excellent outcome using elastic traction. Elastic traction with fulcrum on molars for reduction and inter-maxillary fixation was done in order to stabilize the mandibular condyles into the glenoid fossa. Here we stressed on the effectiveness of continuous traction using elastics and Inter-maxillary fixation (IMF) in achieving a complete repositioning of the mandibular condyles back into the fossa

Condyles were reduced back in glenoid fossa with excellent outcome.

Where manual reduction is not possible, elastic traction and IMF is the only method to reduce condyles. In long standing chronic TMJ dislocation case, only manual reduction was not sufficient. Since no standard rules for the ideal strategy are available till date, initial approach must be conservative so to preserve surgical treatment for later if needed.
A Farroupilha na formação histórica do Rio Grande do Sul: O caso Moysés Vellinho (1945-1964)
Authors: Antunes Soares Fabrício Antônio
Published: December 2023

O presente artigo examina como o capítulo “O Rio Grande e o Prata: Contrastes”, do livro Capitania d’El-Rei do historiador e político Moysés Vellinho, representa historiograficamente a Farroupilha. Para isso, examino, por um lado, como a fonte se articula com a historiografia da sua época e, por outro lado, como a fonte articula a historiografia e as questões políticas e de identidade. Para dar conta do objetivo, a metodologia utilizada para analisar a fonte é a operação historiográfica de Michel de Certeau. A hipótese que norteia o artigo diz respeito a nacionalização da história regional no período de 1940 a 1960. Por fim, constato que a fonte/obra analisada foi um objeto tanto de luta política como de uma escrita da história em que a Farroupilha é o ápice da brasilidade da identidade do sul-rio-grandense.
Historical trends in the study of the phenomenon of wisdom in psychological science
Authors: Mekhtikhanova Natalya N.
Published: December 2023

Кратко описываются традиции изучения мудрости в философский период развития психологии. Мудрость связывалась с нравственной добродетелью и хорошим решением жизненных проблем. Это послужило основой для современного понимания феномена. Излагается хронология изучения мудрости в зарубежной и отечественной психологии. Показано, что существуют два основных подхода в исследованиях – имплицитный и эксплицитный. Анализируются причины долгого игнорирования феномена в психологии и возрождения интереса в современной науке.
Communicative vocabulary in regional media (based on the portal 76.ru)
Authors: Shamanova Marina V.
Published: December 2023

В русском языке коммуникативная лексика и фразеология представлена лексико-фразеологическим полем «Общение». Использование метода моделирования лексико-семантического поля позволяет определить состав и структуру определенной лексической группировки как в системе языка, так и в определенных подсистемах. В данной статье с использованием полевой методики описана коммуникативная лексика в региональных средствах массовой информации на материале портала 76.ru. Коммуникативная лексика на данном публицистическом материале составляет 141 единицу. Анализ семантики коммуникативной лексики позволил выделить 32 микрополя, наиболее объемными из которых являются: «Обмен мнениями, сведениями» и «Сообщение, извещение, уведомление». Четко определяется структура исследуемого лексико-семантического поля. В нем выделяется ядерная и периферийные зоны. Ядерные лексемы отличаются высокой частотностью употребления в тексте, многозначные лексемы употребляются в основном значении или большинство значений в структуре многозначного поля являются коммуникативными. Основными семантическими особенностями периферийной лексики (прежде всего лексики дальней и крайней периферии) является употребление как в основном коммуникативном значении, так и в периферийном, наличие ограничительных стилевых и оценочных сем. К крайней периферии, помимо лексем, относятся фразеологические выражения и устойчивые словосочетания.