bluuebunny/crossref_metadata_2025 huggingface dataset:
Artificial neural network based fault diagnostics for three phase induction motors under similar operating conditions
Authors: Chouhan Abhisar , Gangsar Purushottam , Porwal Rajkumar , Mechefske Christopher K.
Published: April 2020

This paper describes an Artificial Neural Network (ANN) based fault diagnosis methodology for Induction Motors (IM) operating under the same conditions for various speeds and loads. In this study, ten different IM fault conditions are considered. We considered five mechanical faults (bearing fault, unbalanced rotor, misaligned rotor, bowed rotor, rotor with broken bar), four electrical faults (phase unbalance fault with two levels of severity, stator winding fault with two levels of severity), and one healthy motor condition. The current and vibration signals were considered in this work as these signals are generally considered to be the most efficient for the detection of mechanical and electrical faults in IM when used simultaneously. A machine fault simulator was used for the generation of vibration and current signals from different fault conditions. An ANN model was developed in which raw time domain vibration (in three directions) as well as current (in three phases) data are used simultaneously as input and then the fault diagnosis (training and testing) is performed. In this work, the fault diagnosis was attempted when testing was done for the same operating conditions as training. The developed fault diagnosis methods were found to be robust for various operating conditions (speeds and loads) of the IM.
Nonlinear dynamic characteristics of face gear pair for helicopter
Authors: Li Wang , Zhao Ning
Published: April 2020

The face gear pair has been applied in the main reducer of helicopter. Considering the nonlinear backlash, time-varying meshing stiffness and static transmission error, a six degree-of-freedom lumped parameter dynamic model coupling with flexional, torsional and axial motion of the face gear pair for helicopter is developed. This model takes the floating of the pinion as the boundary condition. The nonlinear dynamic characteristics of the face gear pair are analyzed by the help of bifurcation diagram. The effects of rotational speed and supporting stiffness of the pinion on the dynamic responses of the face gear pair are studied in detail by using numerical method. Numerical examples reveal several dynamic evolution mechanisms and motion states including periodic-1, periodic-2, chaotic and quasi-periodic motions. Some research results are helpful for vibration control and dynamic design of the face gear pair for helicopter.
A coupled volume-of-fluid and level set method in interDyMFoam solver
Authors: Baniabedalruhman Ahmad
Published: April 2020

InterDyMFoam is a solver for calculating immiscible two-phase flow in an open source OpenFOAM software. The solver uses the volume-of-fluid method (VOF) for capturing the fluid-fluid interface. The solver is modified to work with the coupled VOF and level set (LS) method. In the proposed method, the VOF is used to capture the interface since it is a mass conserving and the LS is used to calculate the curvature and physical quantities near the interface. A bubble rising in column liquids is used to compare the solvers. The proposed method gives an accurate calculations for the physical properties in two phase flow problems and handles the topological change of the interface.
Large-eddy simulations of the inlet grid-generated turbulence
Authors: Zhiwei Zhang , Bo Wu , Liangliang Zhang , Yuanqing Wang , Longxian Huang
Published: April 2020

In this paper, a new technique of turbulence generation in large eddy simulation (LES) is studied and verified. In order to generate turbulence similar to the wind tunnel test, the proposed grid inlet technique places the grid on the Inlet boundary to achieve the following effects: changing the grid size controls the turbulence integral length scale and changing the distance from inlet controls the turbulence intensity. The purpose of this paper is to explore the domain requirements of grid-inlet technology by studying the turbulence characteristics of three different grid inlets. In particular, this paper further studies the effects of domain sizes on the lateral correlation of fluctuating wind by arranging the transverse positions of monitoring points irregularly and in equal proportion. Meanwhile, the isotropic hypothesis of gird-generated turbulence is verified by power spectrum. The results show that the turbulence intensity is unaffected by the domain sizes, the larger calculation domain corresponds to the gentler changing trend of the lateral correlation of the fluctuating wind and the flow fields under the three different domain sizes basically satisfy the isotropic hypothesis. The above results are helpful for the further application of the grid inlet technique.
Study on anisotropic characteristics of dynamic deformation parameters of phyllite
Authors: Si Fu’an , Xu Jiangbo , Cui Yilun , Fei Dongyang , Li Kun
Published: April 2020

The acoustic wave test was carried out by selecting the joints of the joint surface and the horizontal plane at 0°, 30°, 45°, 60°, 75°, and 90° phyllite samples. According to the corresponding waveform diagram, the starting point is selected, and the dynamic deformation parameters of thousands of rock samples under various angles are calculated. The results show that: The anisotropy characteristics of the dynamic deformation parameters are obvious, and the influence of the variation of the joint surface inclination on the dynamic deformation parameters is achieved by affecting the wave impedance. P-wave impedance and S-wave impedance have different effects on rock dynamic deformation parameters. Generally, P-wave and S-wave impedance should be considered comprehensively for the dynamic deformation parameters of rock samples. Acoustic waves are in the elastic deformation law of the rock sample caused by the propagation in the rock sample is similar to the elastic deformation law caused by the external load acting on the rock sample.
Finite element modelling and dynamic characteristic analysis of the human CTL-Spine
Authors: Dayanand Shreyas , Kumar B R Dhruva , Rao Ankit , C V Chandrashekara , B Khot Mantesh , Shetty Harshvardhan
Published: April 2020

Persistent exposure to whole body vibrations is the fundamental cause for lower back pain and disc degeneration. With an increasing amount of population exposed to whole body vibrations, a significant number of people experience fatal spine diseases. Substantial research is carried out to reduce the risk of spinal injuries. The dynamic characteristics of the cervical, thoracic and lumbar (CTL) region are studied extensively as individual sections of the spine. Few studies have focused on the CTL spine as an assembly of the three segments. In the present work, an authentic three dimensional geometrical model of the cervical, thoracic and lumbar spine is developed in mimics considering its natural curvature and the intervertebral discs are modeled in Design modeler. The natural frequency and mode shapes of the CTL spine are extracted using free vibration modal analysis considering 4.5 kg point mass on C1 vertebra and distributed mass of 40 kg on the CTL spine in Ansys Workbench. Six natural frequencies and their corresponding vibration modes are obtained from the finite element model. The results of this study aims to provide a reliable model for further biomechanical analysis and ergonomics.
Simulation model of human cupula for free vibration analysis
Authors: Prakash Akhilesh Hari , Joshi Anudeep , Babu Darshan , C V Chandrashekara
Published: April 2020

Any dysfunction of vestibular system leads to various diseases, the most common among them is Benign Paroxysmal Positional Vertigo (BPPV). BPPV is most found in elderly people causing vertigo/dizziness which leads to fall and serious injuries. The primary system in inner ear helping in human body balancing and postural adjustment is the cupula. Cupulolithiasis is a type of BPPV caused when otoconia get settles on the cupula. In the present work, a three-dimensional model of cupula and otoconia particle is modelled. A free vibration modal analysis is carried out on the cupula with and without otoconia particle to extract the natural frequency and mode shapes. Change in natural frequency of the cupula due to presence of otoconia particle is presented. Present work has a future scope involving fluid solid interaction (FSI) and extracting response of the cupula incorporating damping to obtain complete dynamic characteristics of cupula. The extracted results help in future investigation of new therapeutical solution to treat BPPV.
The Dynamic Characteristics of a non-linear main landing gear system of an aircraft during landing
Authors: Srivathsa Arjun , Adarsha S S , Narayana M V Bharath , Sridhar K S , C V Chandrashekara
Published: April 2020

The landing gear plays a very important role during landing by absorbing the high impact energy of the aircraft. The main landing gear absorbs the bulk of the load to reduce the load experienced by both the aircraft fuselage and the nose landing gear. In this paper, a mathematical approach is used to extract the dynamic characteristics of the system. A two-degree of freedom mathematical model of the main landing gear is developed. This model is used to derive the dynamic equations of the landing gear system and to study the behaviour of main landing gear during main gear and nose gear touchdown conditions. The non-linear stiffness and damping co-efficient in an Oleo-Pneumatic shock absorber are integrated into the system to achieve a more accurate response of the system. The response of this system is established by adopting a complex modal analysis approach to account for the non-classical damping exhibited by the system. The obtained spring force, damping force and responses are reported. This work provides an alternative approach using complex modal analysis to obtain results for complex systems exhibiting non-linear characteristics.
Free vibration analysis of a discretized aircraft with an integrated biodynamic pilot model – modal approach
Authors: C Hari Gowtham , Balila Adarsha , B N Ankush , C V Chandrashekara
Published: April 2020

This work deals with the formulation of mathematical model for a discretized aircraft with combined seated biodynamic pilot model. The developed model provides scope for exploring the dynamic characteristics of the aircraft system and pilot under various runway operations and landing impacts. Modal analysis approach is used to obtain the free vibration characteristics of multi degrees-of-freedom system. The obtained results like natural frequencies, mode shapes and undamped response curves are reported.
Effects of sampling frequency on estimation accuracies of annual loadings for water quality parameters in different sized watersheds
Authors: Gao Lin , Qi Junyu , Li Sheng , Benoy Glenn , Xing Zisheng , Meng Fan-Rui
Published: April 2020

Potential errors or uncertainties of annual loading estimations for water quality parameters such as suspended solids (SS), nitrate-nitrogen (NO3-N), ortho-phosphorus (Ortho-P), potassium (K), calcium (Ca), and magnesium (Mg) can be greatly affected by sampling frequencies. In this study, annual loading estimation errors were assessed in terms of the coefficient of variation, relative bias, and probability of potential errors that were estimated with statistical samples taken at a series of sampling frequencies for a watershed in northwestern New Brunswick, Canada, and one of its sub-watersheds. Results indicate that annual loading estimation errors increased with decreasing sampling frequency for all water quality parameters. At the same sampling frequencies, the estimation errors were several times greater for the smaller watershed than those for the larger watershed, possibly due to the flushing nature of streamflows in the smaller watershed. We also found that low sampling frequency tended to underestimate the annual loadings of water quality parameters dominated by stormflow events (SS and K) and overestimate water quality parameters dominated by baseflow (Mg and Ca). These results can be used by hydrologists and water quality managers to determine sampling frequencies that minimize costs while providing acceptable estimation errors. This study also demonstrates a novel approach to assess potential errors when analyzing existing water quality data.
Characterization of performance of full-scale tertiary membranes under stressed operating conditions
Authors: Abu-Obaid Sara , Bérubé Pierre , Parker Wayne J.
Published: April 2020

This study sought to identify factors responsible for enhanced fouling of ultrafiltration membranes used in tertiary wastewater treatment under challenging conditions of high flow and low temperature. A detailed analysis of full-scale membrane operating data was conducted, and this was supported by data gathered through a field sampling campaign. Higher average fouling rates and average recoveries were observed during periods of highest flows and lowest temperatures. The results demonstrated that the negative impact of seasonal changes on short-term fouling are readily reversible, while hydraulically irreversible fouling, which is responsible for intermediate and long-term fouling rates, is not effectively recovered by maintenance cleans (MCs) but is recovered by recovery cleans (RCs). An examination of membrane feedwater quality revealed that high fouling rates correlated to an increase in dissolved organic carbon (DOC) concentrations, with the biopolymer fraction of the DOC being most important. Increased capillary suction time (CST) values, which indicate reduced sludge dewaterability, were also observed during high fouling events. It was concluded that seasonal variations result in the increased release of extracellular polymeric substances (EPS) by microorganisms, which leads to higher membrane fouling and worsened dewaterability of the activated sludge.
Inhibition of tetrachloroethene and trichloroethene on methanogenesis in anaerobic sludges from various origins
Authors: Wang A. M. , Hwu C. S. , Wu C. H.
Published: April 2020

Nine anaerobic sludges were screened to obtain the most effective methanogenic inoculum for the anaerobic treatment of groundwater that is contaminated with tetrachloroethene (PCE) or trichloroethene (TCE). The selection was based on the toxicity of PCE or TCE to acetoclastic methanogens in different sludges. The effects of two biological factors, sludge origin and specific acetoclastic methanogenic activity, and a physical factor, specific surface area of sludge, on the degree of inhibition were examined and compared. The fifty percent inhibition concentrations (IC50) of PCE and TCE that were obtained from 30 °C batch inhibition tests ranged from 0.18 to 0.41 and 1.71 to 3.31 mM, respectively, for the examined sludges. The toxicity of the contaminants to anaerobic sludges did not depend on the two biological factors but was closely correlated with the specific surface area of sludge. Suspended sludges, which have higher specific surface areas than granular sludges, suffered much greater inhibition. This paper suggests the use of anaerobic granular sludges as inocula in bioreactors for treating PCE- and TCE-contaminated groundwater to reduce the effect of their inhibition.
Basic criteria for a sustainable water management at the U.S.-México border: the case of ambos Nogales
Authors: Cervera Gómez Luis Ernesto , Rubio Salas Rodolfo
Published: April 2020

This article aims to analyze some basic criteria for a sustainable use of water in an international watershed shared by Mexico and the United States. The study area comprises the region of Ambos Nogales, which is located inside the Upper Santa Cruz River Basin. This portion of the watershed represents the main ecosystem and the main source of water for urban and rural populations located in this region. Following criteria of sustainability the authors revise and adapt to the case of Ambos Nogales, a set of guidelines proposed by the Pacific Institute for Studies in Development, Environment, and Security. These guidelines include the following elements: basic water requirements needed to maintain quality of life in the population and the health of ecosystems; water quality that meets certain minimum standards; human actions and their impact on long-term renewability of freshwater stocks and flows; collection of data concerning water resources, use and quality of water; institutional mechanisms to prevent and resolve conflicts; and a democratic process of water-planning and decision-making. These twin cities have a long history of cooperation and conflict linked to water resources, which makes available enough information to create a diagnostic about the water management inside a binational arena, and allowing to explore possibilities for a better water resources management under a sustainable regime and from an international perspective. Keywords: Sustainability, binational water management, ambos Nogales region.
Evolución del sector manufacturero Bajacaliforniano durante la transición hacia la apertura económica (1975-1993): una perspectiva sistémica
Authors: Niño Contreras Lya Margarita , Arballo Meza Rosa Amelia , Sández Pérez Agustín
Published: April 2020

Se examinan rasgos que caracterizan el comportamiento industrial del sistema de ciudades bajacaliforniano durante el periodo comprendido entre 1975 y 1993. Como ha sido usual, dada su importancia económica y social, el análisis se enfoca al sector de las manufacturas. Entre varios aspectos, destaca la nueva asignación de roles entre grupos industriales manufactureros (GIM), con una profundización en cambios que fueron gestándose desde fines de los setenta. En este sentido, se reconoce en la técnica de “cambio y participación” un método particularmente útil para señalar tales desplazamientos. El corte espacial utilizado, apoyado en una visión sistémica, se ha empleado antes como criterio de agregación (CONEPO, 1988), en tanto que sus objetivos resultan funcionales desde el punto de vista de la economía regional. A su vez, el corte temporal, focaliza una coyuntura económica especialmente relevante, si consideramos los resultados observados en este mismo lapso en el empleo manufacturero a escala nacional. Palabras clave: Baja California, industrialización, economía regional, manufacturas, cambio y participación.
Políticas públicas y seguridad ciudadana: la violencia como problema público
Authors: Fuentes Romero David F.
Published: April 2020

En este artículo se analizan las distintas acciones dirigidas a controlar la violencia, cuyo enfoque suele ser apoyado por la criminología y la perspectiva judicial; así como las acciones dirigidas a prevenirla, y que han sido apoyadas por la epidemiología y la salud pública. Estos enfoques suelen considerarse como posiciones opuestas, dado que para solucionar el crimen violento, la primera busca la solución en más policías y prisiones y la segunda, en el combate a la pobreza. Una de las conclusiones del artículo es el considerar que la mejor solución para combatir el delito y la violencia en los centros urbanos sea a través de una real participación por parte de los miembros de la sociedad para la elaboración de los planes y programas de seguridad, así como determinar prioridades de acción de manera conjunta con el gobierno.
Los cambios en la política agropecuaria y la propiedad social rural en la frontera norte
Authors: Vidaurrázaga Obezo Francisco René
Published: April 2020

El capital privado nacional y extranjero no llegó al campo en los términos en que esperaba el Estado, por lo que los productores del sector social y privado no lograron insertarse en los proyectos especializados que se canalizan a la exportación, generando una descapitalización en los pequeños, medianos y grandes productores que se dedicaban a la producción para el mercado interno. En la frontera norte, la propiedad social sigue siendo importante y seguirá existiendo por mucho tiempo a pesar de los cambios en la política agropecuaria y sobre to-do con los cambios al artículo 27 Constitucional de enero de 1992 y a la promul-gación de la Ley Agraria en febrero de 1992. La organización de los productores, tanto del sector social como privado, está en crisis y la mayoría de los productores trabajan con sus propios recursos y de manera individual. Esto ha dificultado la integración de proyectos productivos. El objetivo del presente trabajo es analizar los cambios en la propiedad social rural (ejidos, comunidades, colonias agrícolas y ganaderas) de la frontera norte con la nueva política agropecuaria.
Estudio urbano-ambiental de las ladrilleras en el municipio de Juárez
Authors: Romo Aguilar María de Lourdes , Córdova Bojórquez Gustavo , Cervera Gómez Luis E.
Published: April 2020

Este trabajo evalúa la situación urbano-ambiental de los hornos ladrilleros tradicionales y los ecológicos en el municipio de Juárez. La evaluación se centra en los aspectos ambientales y socioeconómicos. La producción de ladrillo se sitúa en el sector informal, por lo que no cuenta con un esquema regulatorio ni con el pago de impuestos. Se siguen utilizando las técnicas tradicionales para la elaboración del ladrillo, lo que provoca emisiones altamente contaminantes a la atmósfera. Esto tiene un fuerte impacto en el medio ambiente a nivel binacional, en la región Paso del Norte. Sin embargo, el contexto socioeconómico de los trabajadores de esta industria no permite cambios importantes, además, hace difícil cualquier iniciativa de mejorar y relocalizar los hornos ladrilleros. La principal fuente de información para esta investigación fue una encuesta aplicada al universo de los productores de ladrillo. Los datos de la encuesta se registraron en un sistema de información geográfica permitiendo el análisis de los hornos ladrilleros en un contexto espacial. Finalmente, este documento presenta un perfil descriptivo de la producción de los hornos ladrilleros y de los productores.
Intercambio desigual y complejos urbanos binacionales en la frontera dominicana con Haití
Authors: Alfonso Haroldo Dilla
Published: April 2020

La frontera dominico-haitiana está marcada por profundas asimetrías y el predominio de una relación de intercambio desigual que supone la transferencia de valores desde Haití a República Dominicana. Las relaciones transfronterizas resumen esta contradictoria relación, pero al mismo tiempo constituyen la única forma de supervivencia para más de medio millón de haitianos que habitan la región. Este artículo discute la historia de esta relación y sus tendencias actuales, incluyendo la formación de regiones económicas y complejos urbanos binacionales. La debilidad de las políticas públicas de regulación y la agresiva acción de los actores del mercado generan un escenario muy contradictorio que pudiera conducir a conflictos por el uso de los recursos compartidos, la explotación de la fuerza de trabajo haitiana y la agitación de posiciones nacionalistas.
La formación para el trabajo de los jóvenes desde las organizaciones de la sociedad civil en América Latina y el Caribe
Authors: Girardo Cristina , De Ibarrola María
Published: April 2020

En este artículo se aborda el estudio de las organizaciones de la sociedad civil como agentes innovadores en la ejecución de programas para la formación del trabajo dirigida a jóvenes, aludiendo a las formas, los modelos y los cambios que las políticas de formación para el trabajo tuvieron en América Latina, y en el Caribe. En el plano teórico se destaca la importancia del espacio local y las políticas de descentralización, como producto de las reformas del Estado, y la innovación en la gestión de los municipios, por constituir el marco en el cual se desarrollan y actúan las OSC, que se suman a la idea del espacio público desde una nueva concepción: como una interacción entre esferas privadas y estatales. Se describen así mismo las características de las organizaciones estudiadas: su perfil institucional, la población atendida, así como los enfoques, estrategias de intervención y diseño de instrumentos que las caracterizan. Se analiza también el caso de México y sus especificidades. Palabras clave: jóvenes, desarrollo local, descentralización, formación para el trabajo, organizaciones de la sociedad civil.
Organizaciones civiles y gobierno: un eslabón estratégico en la transición
Authors: Lizárraga Guillermina
Published: April 2020

La relación entre organizaciones civiles (OC) y gobierno es un tema estratégico para el análisis del devenir político, social y económico que ha tenido lugar de las dos últimas décadas a la fecha en el contexto tanto nacional como internacional. En este caso, la exposición del tema gira en torno a la reedición de la política social en el marco de la reforma del Estado como eje del encuentro en terrenos de acción comunes de estos dos actores sociales hasta hace poco contrapuestos. El objetivo principal de este trabajo es arrojar una visión pragmática acerca del curso que ha seguido la relación entre OC y gobierno en los términos discursivo y operativo. Es decir, se busca trascender el idealismo con el que suele tratarse el tema de las OC, así como el prejuicio político de su relación con el gobierno al proponer que de dicho encuentro emerge un ente particular, inédito, cuya identidad propia rebasa, mas no necesariamente elimina, los modelos civiles y gubernamentales de participación social y acción política de los que emana. Palabras clave: Organizaciones civiles, gobierno, política social, reforma del Estado, encuentro.
Association of Virulence Genes with Antibiotic Resistance in Pakistani Uropathogenic E. coli Isolates
Authors: Haq Khayam ul , Noreen Shazia , Sehgal Sheikh A. , Tahir Rana A. , Essa Amjad , Ihsan Awais , Hassan Mahreen ul , Iqbal Waheed , Hussain Masroor , Hussain Hamid , Siraj Sami
Published: April 2020

Background:

Escherichia coli various strains can cause alarmingly serious infections.
Countries like Pakistan harbour the class of bacteria with one of the highest rates of resistance, but
very little has been done to explore their genetic pool.

Objectives:

This study was designed to find out the frequency of virulence genes of Uropathogenic
E. coli and their association with antibiotic resistance along with the evolutionary adaptation of the
selected gene through the phylogenetic tree.

Methods:

Isolates from 120 urinary tract infected patients were collected. Antibiotic sensitivity
was detected by the disk diffusion method and DNA extraction was done by the boiling lysis
method followed by PCR-based detection of virulence genes. The final results were analysed using
the chi-square test.

Results:

The isolates were found to be least susceptible to nalidixic acid, followed by ampicillin,
cotrimoxazole, cefotaxime, ciprofloxacin, aztreonam, amoxicillin, gentamycin, nitrofurantoin and
imipenem. The iucC was the most common virulence gene among the resistant isolates. About
86% of the collected samples were found to be multi-drug resistant. Statistical analysis revealed a
significant association between the iucC gene and resistance to ampicillin (P=0.03) and amoxicillin
(P=0.04), and also between fimH and resistance to aztreonam (P=0.03).

Conclusion:

This study unravels the uncharted virulence genes of UPEC in our community for the
very first time. We report a high frequency of the iucC and fimH virulence genes. This, along with
their positive association with resistance to beta-lactam antibiotics in the studied community,
indicates their important role in the development of complicated UTIs.
Synthesis of new Enrofloxacin Derivatives as Potential Antibiofilm Drugs Against Staphylococcus Aureus and Klebsiella Pneumoniae
Authors: Siddiqui Hina , Haniffa Haroon M. , Ahmed Ayaz , Choudhary Muhammad I.
Published: April 2020

Background:

The antimicrobial resistance due to biofilm formation among bacteria is a
significant problem in the healthcare and food industries.

Objective:

The current study describes the synthesis of enrofloxacin derivatives 2-17, and the
evaluation of their anti-bacterial and anti-biofilm activities.

Methods:

Compounds 2-17 were synthesized through the acylation of enrofloxacin with thionyl
chloride, followed by reaction with different aromatic amines. The new analogues identified among
the sixteen compounds were 2-7, 11, 14, and 17.

Results:

Compound 2 appeared to be effective against pathogens S. aureus as well as K. pneumonia,
whereas, compound 11 was found active against K. pneumonia only. Compound 2 inhibited >75%
biofilm formation of S. aureus at 20 μg/mL and K. pneumonia at 10 μg/mL concentrations. These
doses are far below the bactericidal concentration of compound 2, suggesting the anti-virulence
mechanism of these compounds. Compound 11 inhibited 60% biofilm formation of K. pneumoniae
at 70 μg/mL concentration. Compound 5 inhibited the biofilm of K. pneumoniae at 62 μg/mL concentration
but also had bactericidal properties at this concentration. Interestingly, compound 2 eradicated
the preformed biofilm of both the pathogens at much lower doses as compared to control drug,
gentamycin and substrate, enrofloxacin. Cytotoxicity of compounds 2–17 was checked by a standard
method using 3T3 normal cell lines (mouse fibroblast), all compounds were found to be noncytotoxic.

Conclusion:

These compounds can be used alone or with FDA approved drugs to overcome biofilm
related K. pneumoniae and S. aureus infections.
MiR-134, Mediated by IRF1, Suppresses Tumorigenesis and Progression by Targeting VEGFA and MYCN in Osteosarcoma
Authors: Ma Zhuo , Li Kai , Chen Peng , Pan Qizheng , Li Xuyang , Zhao Guoqing
Published: April 2020

Background:

Osteosarcoma (OS) is a prevalent primary bone malignancy and its distal metastasis
remains the main cause of mortality in OS patients. MicroRNAs (miRNAs) play critical roles during cancer
metastasis.

Objective:

Thus, elucidating the role of miRNA dysregulation in OS metastasis may provide novel therapeutic
targets.

Methods:

The previous study found a low miR-134 expression level in the OS specimens compared with paracancer
tissues. Overexpression of miR-134 stable cell lines was established. Cell viability assay, cell invasion
and migration assay and apoptosis assay were performed to evaluate the role of miR-134 in OS in vitro.

Results:

We found that miR-134 overexpression inhibits cell proliferation, migration and invasion, and induces
cell apoptosis in both MG63 and Saos-2 cell lines. Mechanistically, miR-134 targets the 3'-UTR of VEGFA and
MYCN mRNA to silence its translation, which was confirmed by luciferase-reporter assay. The real-time PCR
analysis illustrated that miR-134 overexpression decreases VEGFA and MYCN mRNA levels. Additionally, the
overexpression of VEGFA or MYCN can partly attenuate the effects of miR-134 on OS cell migration and
viability. Furthermore, the overexpression of miR-134 dramatically inhibits tumor growth in the human OS cell
line xenograft mouse model in vivo. Moreover, bioinformatic and luciferase assays indicate that the expression
of miR-134 is regulated by Interferon Regulatory Factor (IRF1), which binds to its promoter and activates
miR-134 expression.

Conclusion:

Our study demonstrates that IRF1 is a key player in the transcriptional control of miR-134, and it
inhibits cell proliferation, invasion and migration in vitro and in vivo via targeting VEGFA and MYCN.
Efficacy and safety of traditional Chinese medicine for the treatment of epilepsy: a meta-analysis of randomized controlled trials
Authors: Chen Rongrong , Feng Chenxi , Wang Keer , Zhao Huawei , Yu Jie , Xu Zhenghao
Published: April 2020

Objective:

To evaluate the efficacy and safety of traditional Chinese medicine (TCM) in the
treatment of epilepsy.

Methods:

A comprehensive search of database in both Chinese and English was performed. Data
from the selected studies was extracted and analyzed independently by two authors.

Results:

Twenty-two randomized controlled trials were included in the meta-analysis with a total of
1773 patients. Among them, three trials (n=166) focused on TCM monotherapy, while the other 19
trials (n=1607) assessed the benefit of TCM add-on therapy to antiepileptic drugs (AEDs). For the
efficacy, meta-analysis found (1) TCM monotherapy had a higher effective rate compared with AEDs
(OR=6.007, 95%CI: 2.570-14.037, Z=6.007, P<0.001); (2) the add-on of TCM increased the
effective rate (OR=3.123, 95%CI: 2.356, 4.140), Z=7.916, P<0.001). In terms of safety, the add-on
of TCM reduced the rate of total AEs (OR = 0.407, 95%CI: 0.274-0.605, P <0.0001) as well as AEs
regarding the gastrointestinal and nervous system. Nineteen different TCM prescription was used in
these RTCs. Among them, the five most frequently used herbs were Acorus tatarinowii (14 out of 19),
Wolfiporia Cocos (10 out of 19), Pinellia Ternata (9 out of 19), Licorice Root (9 out of 19) and
Rhizoma Gastrodiae (8 out of 19).

Conclusion:

TCM is an efficacy and safety strategy for the mono- or add-on treatment of epilepsy.
However, as the small sample size, the diversified composition of TCM prescriptions, and the low
quality of study design, further studies remain needed.
Recent Advances on Urban Taxi Sharing Systems with the Path Arrival Probability
Authors: Hongyan Dui , Chi Zhang
Published: April 2020

Background :

Taxi sharing is an emerging transportation arrangement that has helped improve
passengers’ travel efficiency and reduce costs. This study proposes an urban taxi sharing system.

Methods:

Considering each side congestion of the transport network, their corresponding reliability
and failure probability are analyzed. Under the constraints of the number of passengers and their
time windows, the analysis is performed on passengers whose optimal path is inclusive.

Results:

According to the optimal strategy, the different passengers can be arranged into the same
taxi to realize the taxi sharing. Then the shared taxi route can be optimized.

Conclusion:

Due to the reasonable vehicle route planning and passenger combination, these can effectively
alleviate the traffic congestion, save the driving time, reduce the taxi no-load rate, and save
the driving distance. At last, a numerical example is used to demonstrate the proposed method.
Rekonstruksi Sosial Budaya Fenomena Bunuh Diri Masyarakat Gunungkidul
Authors: Asih Kabut Yuli , Hiryanto Hiryanto
Published: April 2020

Abstrak            Artikel jurnal ini berusaha mengulas historisitas dan pemecahkan masalah dalam bentuk rekonstrusi untuk mencapai reduksi pada fenomena bunuh diri sebagai fenomena langka dari pada biasanya yang marak terjadi di Kabupaten Gunungkidul. Metode yang digunakan ialah metode analisis deskriptif, yakni berusaha menggambarkan secara jelas dan  sistematis obyek kajian, teori kesejahteraan sosial, lalu menganalisis perbandingan bahasan riset. Ulasan didasarkan pada analisis data kepustakaan yang diperoleh melalui kajian kepustakaan (library research). Secara sederhana penawaran rekonstruksi kajian ini mengaitkan dimensi sosial (kepekaan masyarakat terhadap fenomena) dan budaya (reinterpretasi pulung gantung). Hal tersebut berdasarkan pengamatan penulis yang menganggap bahwa masyarakat di Kabupaten Gunungkidul belum mencapai titik kesejahteraan sosial sehingga memunculkan fenomena bunuh diri. Rekonstruksi mampu dianggap sebagai pokok pemikiran kesejahteraan sosial sebagai upaya preventif, dan kuratif (rehabilitasi) agar masyarakat mampu berperan sosial dengan baik dan benar. Abstract            This journal article attempts to review the historicity and problem solving in the form of reconstruction to achieve a reduction in the phenomenon of suicide as a rare phenomenon that is usually rife in Gunungkidul Regency. The method used is descriptive analysis method, which is trying to describe clearly and systematically the object of study, social welfare theory, then analyze the comparison of research topics. The review is based on the analysis of library data obtained through library research (library research). In simple terms the reconstruction offer of this study links the social dimensions (community sensitivity to phenomena) and culture (reinterpretation of pulungantung). This is based on the observation of the writer who considers that the community in Gunungkidul Regency has not reached the point of social welfare so that it raises the phenomenon of suicide. Reconstruction can be considered as the main thought of social welfare as a preventive and curative effort (rehabilitation) so that the community is able to play social roles properly and correctly.
Efektivitas Program Bina Prestasi dalam Peningkatan Mutu Pendidikan di SD Santa Theresia 1 Pangkalpinang
Authors: Sugiyarti Sri , Oktarina Oktarina
Published: April 2020

AbstrakTingkat persaingan sekolah swasta untuk bisa bertahan di tengah maraknya sekolah-sekolah negeri sehingga diperlukan program-program yang mampu meningkatkan mutu pendidikannya sehingga masyarakat tidak meninggalkan sekolah swasta. Tujuan dari penelitian ini untuk mengetahui efektivitas program Bina Prestasi untuk meningkatkan mutu pendidikan di SD Santa Theresia 1 Pangkalpinang. Penelitian ini menggunakan metode kualitatif deskriptif. Teknik pengumpulan data menggunakan teknik wawancara, observasi, dokumentasi dan penyebaran angket. Hasil penelitian menunjukkan Program Bina Prestasi adalah  wadah khusus untuk meningkatkan prestasi siswa dalam bidang akademik, didalamnya dibina siswa-siswa yang berminat dalam bidang IPA, Matematika, Bahasa Indonesia, Bahasa Inggris dan Seni. Hasilnya siswa dalam program ini telah mencetak berbagai prestasi baik local maupun nasional, hingga internasional. Hasil penghitungan  efektifitas juga menunjukkan bahwa program ini efektif dalam meningkatkan  mutu pendidikan di SD Santa Theresia 1, hal ini terbukti dari hasil angket per mata pelajaran, yakni  Bahasa Indonesia dengan skor  76,81 , Matematika dengan skor 78,33,  IPA dengan skor 76,07,  Seni dengan skor  76,66 dan Bahasa Inggris dengan skor tertinggi 84,12. Hal ini sejalan dengan diraihnya berbagai prestasi dalam lima bidang mata pelajaran tersebut baik di tingkat lokal maupun nasional. AbstractThe level of competition of private schools to be able to survive during it he rises of public schools so that programs are needed that can improve the quality of education so that people do not leave private schools. The purpose of this study was to determine the effectiveness of the Bina Prestasi program to improve the quality of education in SD Santa Theresia 1 Pangkalpinang. This research uses the descriptive qualitative method. Data collection techniques using interviews, observation, documentation and questionnaire distribution. The results showed the Achievement Development Program is a special place to improve student achievement in the academic field, in which fostered students who are interested in the fields of Natural Sciences, Mathematics, Indonesian, English and Arts.  As a result students in this program have scored a variety of achievements both locally and nationally, to internationally. The results of the effectiveness calculation also show that this program is effective in improving the quality of education in SD Santa Theresia 1, this is evident from the results of the questionnaire per subject, namely Indonesian with a score of 76.81, Mathematics with a score of 78.33, Science with a score of 76,  07, Art with a score of 76.66 and English with the highest score of 84.12. This is in line with the achievement of various achievements in the five subject areas both at the local and national level.
PEMBELAJARAN BERBASIS PROJECT UNTUK MENINGKATKAN PRESTASI BELAJAR SISWA DI SMA NEGERI 6 YOGYAKARTA
Authors: Triwulandari Andriyani
Published: April 2020

Peningkatan kualitas pendidikan merupakan tujuan dalam pembangunan pendidikan nasional kita, guru sebagai pendidik perlu lebih memperhatikan dalam memilih metode mengajar yang efektif dan efisien untuk mencapai hasil secara optimal. Penelitian ini bertujuan untuk mengetahui: 1) peningkatan prestasi belajar siswa dengan pembelajaran berbasis project pada mata pelajaran geografi kompetensi dasar dinamika hidrosfer dan dampaknya terhadap kehidupan; 2) peningkatkan aktivitas siswa dalam pembelajaran geografi kompetensi dasar dinamika hidrosfer dan dampaknya terhadap kehidupan. Penelitian ini merupakan penelitian tindakan kelas (Classroom Action Research). Pendekatan penelitian ini adalah pendekatan kualitatif. Penelitian dilakukan di SMAN 6 Yogyakarta tahun pelajaran 2019/2020. Subyek penelitian adalah guru dan siswa kelas X IPS SMAN 6 Yogyakarta, yang berlangsung dalam dua siklus yang masing-masing meliputi empat tahap, yaitu : 1) Persiapan Tindakan, 2) Pelaksanaan Tindakan, 3) Pemantauan dan Evaluasi, dan 4) Analisis dan Refleksi. Hasil penelitian menunjukkan dengan diterapkannya pembelajaran berbasis Project pada mata pelajaran geografi kompetensi dasar dinamika hidrosfer dan dampaknya terhadap kehidupan 1) terjadi peningkatan ketuntasan belajar siswa dari 54% menjadi 86%; 2) terjadi peningkatan skor dari 2,76 (kualifikasi kurang baik) menjadi 3,87 (kualifikasi baik).
POT BUNGA UNTUK MENINGKATKAN PENGETAHUAN AKAR PANGKAT TIGA PADA SISWA KELAS VI SD
Authors: Wahyuni Dwi
Published: April 2020

Tujuan penelitian ini adalah untuk meningkatkan pengetahuan akar pangkat tiga dengan menggunakan gambar pot bunga pada siswa kelas VI SDN Karangtengah Baru. Penelitian ini merupakan penelitian tindakan kelas (PTK), yang terdiri dari dua siklus. Setiap siklus meliputi kegiatan : perencanaan, tindakan, observasi, dan refleksi. Subyek penelitian adalah 28 siswa. Teknik pengumpulan data yang digunakan adalah teknik observasi, catatan lapangan, tes, angket, observasi, dokumentasi. Catatan lapangan digunakan untuk mengetahui aktivitas guru dan siswa dalam pembelajaran. Tes digunakan untuk mengetahui pengetahuan siswa, dan angket untuk mengetahui respon siswa terhadap pembelajaran akar pangkat tiga pada bilangan kubik menggunakan gambar pot bunga. Hasil penelitian menunjukkan bahwa penggunaan gambar pot bunga meningkatkan pengetahuan akar pangkat tiga bilangan kubik. Semua kriteria keberhasilan yang ditetapkan dalam penelitian telah tercapai, diantaranya (1) hasil tes menunjukkan peningkatan nilai rata-rata kelas; (2) persentase siswa yang mencapai nilai KKm yang ditetapkan meningkat; (3) respon siswa terhadap pembelajaran akar pangkat tiga pada bilangan kubik dengan gambar pot bunga dalam kategori baik.
PENINGKATAN PEMAHAMAN SISWA TENTANG POLA BILANGAN LONCAT DENGAN METODE PERMAINAN
Authors: Banniyatun Banniyatun
Published: April 2020

Penelitian ini bertujuan untuk mengetahui keefektifan penggunaan metodepermainan loncat lantai untuk meningkatkan pemahaman siswa tentang pola bilangan pada siswa kelas satu SD Negeri Pandanpuro 1. Metode penelitian yangdigunakan adalah penelitian tindakan kelas yang terdiri dari dua siklus. Setiapsiklus dilaksanakan melalui empat tahap yaitu perencanaan, pelaksanaan, pengamatan, dan refeleksi. Pengumpulan data yang digunakan dengan tes evaluasi dan pengamatan pada saat pembelajaran berlangsung. Data yang diperolehdianalisis secara deskriptif kualitatif. Berdasarkan penelitian penulis memperoleh hasil yaitu terjadi peningkatan pemahaman siswa tentang pola bilangan setelahmenggunakan metode permainan loncat lantai. Hal ini terbukti dengan adanyapeningkatan hasil evaluasi siswa yaitu pada data awal dengan nilai rata- rata 63.33; pada siklus I meningkat yaitu dengan nilai rata- rata 86.67; dan pada siklusII meningkat dengan nilai rata- rata 90. Selain itu penggunaan metode permainanloncat lantai juga dapat meningkatkan motivasi belajar siswa. Siswa menjadi lebihaktif, antusias dan lebih konsentrasi dalam mengikuti pembelajaran di kelas karena pembelajaran yang disajikan menjadi lebih asik, menarik, danmenyenangkan. Berdasarkan penelitian tersebut penulis dapat menyimpulkanbahwa metode permainan loncat lantai dapat meningkatkan pemahaman siswatentang pola bilangan pada siswa kelas 1 SD Negeri Pandanpuro 1 KecamatanPakem.
STORY TELLING SEBAGAI MEDIA PENDIDIKAN KARAKTER KEBANGSAAN DI DAERAH 3T
Authors: Khanifah Siti
Published: April 2020

Tujuan penulisan ini paper yaitu: menganalisis peranan story telling dalam pendidikan karakter kebangsaan di daerah 3T (Terdepan, Terluar, Terpencil), hambatan penerapan story telling, dan upaya yang dilakukan dalam mengatasi hambatan penerapan story telling di daerah 3T, khususnya di SD Negeri 249 Halmahera Selatan. Metode penelitian yaitu kualitatif menggunakan pendekatan studi kasus dengan lokasi penelitian SD Negeri 249 Halmahera Selatan. Subjek penelitian yaitu siswa dan guru SD Negeri 249 Halmahera Selatan. Data penelitian dikumpulkan melalui teknik dokumentasi, wawancara, dan pengamatan. Analisis data dengan mengorganisasikan, meredukssi data, dan menyajikan dalam pembahasan. Hasil penelitian ini yaitu: (1) Peranan story telling dalam pendidikan karakter kebangsaan sebagai media pembelajaran yang dilakukan di dalam pembelajaran dan di luar pembelajaran. (2) Hambatan yang dihadapi guru dalam penerapan story telling sebagai media pendidikan karakter kebangsaan yaitu kompetensi guru terkait dengan keterbatasan pengetahuan guru akan biografi para pahlawan. Faktor eksternal terkait dengan keterbatasan akses informasi dan belum ada standar evaluasi ketercapaian pembentukan karakter kebangsaan. (3) Upaya yang dilakukan oleh guru yaitu guru menggunakan cerita yang bervariatif tidak selalu kisah tokoh pahlawan atau legenda, akan tetapi tokoh yang dekat dengan kehidupan sehari-hari peserta didik, penyediaan buku bacaan. Student center dengan memberikan kesempatan peserta didik bercerita sehingga story telling tidak berpusat pada guru.
PEMBELAJARAN BAHASA RESEPTIF BAGI ANAK AUTISME DENGAN PENDEKATAN DISCRETE TRIAL TRAINING(DTT)
Authors: Badari Rofi
Published: April 2020

Penelitian ini merupakan penelitian tindakan kelas berupa penerapan metode discrete trial training (DTT) dalam upaya meningkatkan bahasa reseptif anak dengan autism dalam belajar. Penelitian ini dilaksanakan pada kelas awal di kelas 1 SD Negeri 33 pangkalpinang. Penelitian ini akumulatif selama 10 jam pelajaran yang terbagi dalam 5 kali pertemuan. Pertemuan dimulai siklus I tanggal 2 – 3 Oktober 2015, siklus II dilaksanakan pada tanggal 9-10 Oktober 2015 dan siklus II dilaksanakan pada tanggal 6 Nopember 2015. Ketercapaian dilihat berdasar pada penguasaaan materi ditiap tahap pembelajaran. Setiap stimulus dan respon anak didokumentasikan untuk mengetahui tingkat pengulangan dengan semakin sedikit pengulangan menyatakan pemahaman anak. Hasil yang diperoleh pada siklus I subyek Re dapat menguasai 6 dari 10 materi dan subyek RI menguasai 5 materi dari 10 materi, pengulangan stimulus lebih dari 3 kali. Siklus II dilaksanakan dengan merubah stimulus berupa peningkatan reward hasil kegiatan subyek Re dapat menguasai 7 dari 10 materi dan subyek RI menguasai 6 materi dari 10 materi, pengulangan stimulus rata rata 2 kali. Siklus III modifikasi berupa penyesuaian tekanan instruksi yang disesuaikan dengan respon anak. subyek Re dapat menerima respon dengan nada yang lembut menguasai 8 dari 10 materi dan subyek ri menguasai 7 materi dari 10 materi, pengulangan stimulus rata rata dibawah 2 kali. Dengan melihat pengulangan stimulus singkat dan respon yang cepat dan benar maka pembelajaran dianggap berhasil.