bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH DISKON DAN KUALITAS PRODUK TERHADAP KEPUTUSAN PEMBELIAN BUAH-BUAHAN IMPOR PADA TOKO NAYLA BUAH BENGKULU
Authors: Eriza Nada , Bustami Taufik
Published: July 2024

The aim of the research is to determine the effect of discounts and product quality on purchasing decisions for imported fruit at the Nayla Buah Bengkulu shop. And to find out which factors most dominantly influence purchasing decisions.
This research used quantitative methods on 150 respondents. The population used in this research was consumers of the Bengkulu Nayla Fruit Shop and sampling in this research used a non-probability sampling technique.
Based on the results of multiple linear regression, the regression equation Y
= 9.496 + 0.466 (X1) + 0.414 (X2) is obtained. The research results and hypothesis show that discounts and product quality have a partial or simultaneous positive effect on purchasing decisions.
Keywords: Discounts, Product Quality and Purchasing Decisions.
RESPON PESERTA DIDIK TERHADAP LKPD BERBASIS ETNOMATEMATIKA PADA MATERI BANGUN RUANG
Authors: Fitriasih Eka Destareiza  , Nuryadi  , Supriyanti
Published: July 2024

Penelitian ini bertujuan untuk mengidentifikasi tanggapan peserta didik terhadap LKPD yang berbasis etnomatematika dalam pembelajaran matematika pada topik bangun ruang. Metode penelitian yang digunakan adalah deskriptif kuantitatif, yang bertujuan untuk mengevaluasi kepraktisan LKPD berbasis etnomatematika. Populasi dalam penelitian ini yaitu peserta didik kelas VII SMP Negeri 1 Sedayu dengan sampel penelitian ini adalah 16 peserta didik kelas VIID dan 32 peserta didik kelas VIIE SMP Negeri 1 Sedayu. Instrumen yang digunakan yaitu LKPD berbasis Etnomatematika dan lembar angket respon peserta didik. Teknik analisis data yang digunakan yaitu menggunakan model Miles & Huberman. Berdasarkan hasil analisis kepraktisan, LKPD berbasis Etnomatematika dikatakan praktis ketika rata-rata dari skor penilaian memenuhi kriteria dengan minimal praktis. Dapat disimpulkan bahwa penggunaan LKPD berbasis Etnomatematika yang memuat indikator kemampuan pemecahan masalah pada materi bangun ruang pada uji coba skala kecil menunjukkan kriteria sangat praktis dengan skor rata-rata 75,18, kemudian pada uji coba skala besar dikatakan sangat praktis berdasarkan rata-rata 74,25. Sehingga dapat disimpulkan bahwa penggunaan LKPD berbasis Etnomatematika untuk materi bangun ruang efektif dalam konteks pembelajaran matematika.  
Kata Kunci: LKPD, etnomatematika
Evolución del tratamiento con antibióticos en pacientes con tuberculosis: revisión sistemática
Authors: Andrade Nelson E. , Monroy Emily S. , Párraga Daver S. , Párraga Angie S.
Published: July 2024

La tuberculosis es una enfermedad infecto-contagiosa provocada por el microorganismo Mycobacterium tuberculosis que pese a que en la actualidad se han logrado numerosos avances científicos cruciales para el manejo del diagnóstico y tratamiento, la enfermedad sigue siendo un desafío para los diferentes sistemas de salud. El objetivo fue analizar la evolución histórica del tratamiento con antibióticos en pacientes con tuberculosis. Metodología: Se realizó una revisión bibliográfica de diversos artículos científicos relevantes de distinta índole, a través del uso de bases de datos académicas como: PubMed, Scielo y Scholar Google. A través del análisis de los artículos seleccionados se abordaron 4 temáticas principales: evolución en línea temporal de los tratamientos antibióticos para combatir la tuberculosis; resultados clínicos en pacientes gracias al desarrollo de nuevos antibióticos; enfoques actuales contra la resistencia a antibióticos de TB; perspectivas futuras de los avances tecnológicos para el diagnóstico y tratamiento de la enfermedad. Se determinó a la tuberculosis como desafío para la salud pública, debido a la aparición de nuevas cepas resistentes contra los tratamientos convencionales.
Women Building the Colonial Archive. Legal Authority, Female Knowledge and Affective Mobility in the Sixteenth-Century Iberian Atlantic World
Authors: Ramírez Velázquez Juan Manuel
Published: July 2024

In the sixteenth century, the transition from medieval unity to an expansionist state brought broader legal access and the bureaucratization of the Spanish Empire, leading to a diversified legal engagement among social groups. This backdrop is crucial in understanding how women from various backgrounds utilized the legal system. The article examines a set of letters (1560-1562) written by a Spanish widow to her son in Mexico and three judicial cases (1552, 1561, 1569) filed by transatlantic white women of different socioeconomic statuses, all seeking economic improvement. Through these examples, the article explores how these women navigated the legal system using what I have called affective mobility in early modernity, employing emotional, rhetorical, and narrative strategies. Their stories, mirroring popular chronicles, challenged the male-dominated legal sphere. The article highlights the prominent role of women in the colonial archive, intertwining their experiences with men’s, demonstrating their use of personal details and honorable depictions for legal and economic benefits.
التبليغ في حياة أهل البيت (عليهم السلام) وأهميته في تغيير الواقع
Authors: ثاني عامر نايف حسن , القريشي أ.د. صالح جبار
Published: July 2024

البحث يهدف إلى بلورة فكرة التبليغ التي اتخذت طابعاً عالمياً بعد إنفتاح العالم المعاصر على الإسلام، وجَعل الوظيفة التبليغية مستندة إلى أُسّس علمية وقواعد منهجية مدروسة بدراسة علمية أكاديمية من خلال إبراز الجانب التبليغي في حياة أهل البيت (عليهم السلام)، وكيفية تنّوع الأساليب التبليغية لهداية الآخرين، مضافاً إلى تقوية دافع التبليغ وتسليح المبلغ بأهم الأساليب المؤثرة التي تضمن نجاح المبلّغ في اداء مهمته والابتعاد عن الأساليب غير المشروعة.
الثنائيات الضدية بين البناء الفني والذوق الجمالي (الحِكم القصار في نهج البلاغة اختياراً)
Authors: العرداوي أ.م. د مرتضى شناوة فاهم
Published: July 2024

تعد الحِكم القصار بمثابة منبهات  مقروءة غايتها ايصال فكرة معينة إلى المتلقي لتحقيق الاقناع، فقد قام الإمام ع باتباع استراتيجية معينة للتأثير بالجمهور و استمالتهم إليه، بطريقة بنائية خاصة عبر تقنية التضاد المكثّف،  يسعى هذا البحث إلى استكشاف المتتاليات التضادية التي ركّز عليها الإمام علي(ع) في إيصال متبنياته الفكرية إلى الناس، و معرفة الأثر الجمالي لها في نفس المتلقي، وقد جرت طريقة البحث على عرض النصوص وتحليلها ضمن الطرق البنائية الفنية للوصول إلى المقاصد الدلالية التي كان الإمام ع يسعى اليها، وكذلك بيان الأثر الجمالي له.
Morphometric MRI Study of Third Ventricle of Brain among Bangladeshi Adults
Authors: Tahmina Mousomi , Khan Maria , Jahan Isot , Leeza Nafrina Islam , Fatima Kaniz , Islam Nazia Binte , Rahman A.K.M Shahidur
Published: July 2024

Background: The third ventricle of the brain is a small median cleft located in the diencephalon between right and left thalamus; anteriorly it communicates to the lateral ventricles by foramen of Monro, posteriorly connects to the fourth ventricle through the cerebral aqueduct. Morphometry and accurate measurements of the brain ventricles have clinical importance because various diseases affect the size and morphology of the ventricles. Objective: This study was aimed to determine the morphometry of third ventricle of brain by magnetic resonance imaging (MRI) scan. Methods: This cross-sectional study was conducted at Department of Anatomy, Dhaka Medical College, Dhaka, Bangladesh from January 2020 to December 2020. Patients referred by Department of Medicine, Dhaka Medical College Hospital (DMCH) for MRI were enrolled as study subjects. Total 100 adult Bangladeshi subjects (50 male and 50 female) were selected following selection criteria. Their MRI of brain was done by MAGNETOM VIDA (3T Tesla) SIEMENS MRI machine following standard procedure. The MRI scans were evaluated by registered radiologists. All parameters were measured from the soft copy of MRI scans using RadiAnt DICOM Viewer. Results: The mean (±SD) maximum height of the third ventricle was 23.69 ± 1.13 mm in male and 22.38 ± 0.72 mm in female, that was significantly larger in male (p<0.001). The mean (±SD) anterior-posterior length of third ventricle was 27.17 ± 0.67 mm and 26.16 ± 0.58 mm in male and female respectively, which was significantly higher in male than female (p<0.001). However, no significant difference was observed in mean (±SD) anterior-posterior commissural distance between male and female (26.47 ± 1.6 mm and 26.06 ± 1.00 mm, p= 0.129). The mean (±SD) maximum width of third ventricle was found significantly higher in male than female (4.33 ± 0.41 mm versus 3.68 ± 0.68 mm, p<0.001). Conclusion: The maximum height, anterior to posterior length and maximum width of third ventricle ........
Correlation of Estimated Gestational Age with the Anterior-Posterior Thigh Diameter and Other Parameters of Fetal Biometry
Authors: Maruf Dr. Mohammed Abdoullah Al , Sultana Dr. Safia , Karim Dr. Ataul , Sultana Dr. Maria
Published: July 2024

Background: Accurate gestational age estimation is vital for tracking pregnancy, identifying growth issues, and guiding clinical decisions. Including anterior-posterior thigh diameter (APTD) in fetal biometry enhances fetal health assessment. Correlating EGA with APTD and other biometry parameters is crucial for evaluating fetal growth and development. This study aimed to evaluate the correlation of estimated gestational age with the anterior-posterior thigh diameter and other parameters of fetal biometry. Methods: This cross-sectional study was conducted at the Department of Radiology and Imaging, Mymensingh Medical College & Hospital, Mymensingh, Bangladesh, from January 2010 to January 2012. A total of 250 healthy women between the 24th and 38th weeks of normal pregnancy were enrolled using a purposive sampling technique. Data analysis was performed using SPSS version 23.0. Results: More than one-third (34.0%) of participants were aged 21-25 years. The mean gestational age was 30.93 ± 4.32 weeks, and over half (56.4%) were primigravida. Significant positive correlations were found between fetal anterior-posterior thigh diameter and gestational age (r=1.0; p<0.001), bi-parietal diameter (r=0.856; p<0.001), head circumference (r=0.962; p<0.001), abdominal circumference (r=0.972; p<0.001), and femur length (r=0.948; p<0.001). Conclusion: The fetal anterior-posterior thigh diameter shows significant positive correlations with several parameters, including gestational age, biparietal diameter, head circumference, abdominal circumference, and femur length in this study.
Clinical and Audiological Outcome of Surgical Treatment in Patients with Adenoid Hypertrophy
Authors: Imtiaz Dr. S. M. Nafeez , Rahman Dr. Md. Sahidur , Tasrif Dr. Samir Mohammad , Islam Dr. Md. Mahbubul , Sakender Md. Sha. , Nath Dr. Mridul Deb , Mahmud Dr. Towfiq
Published: July 2024

Background: Adenoid hypertrophy is a common condition in childhood, which may be associated with recurring acute otitis media, otitis media with effusion (OME), and obstructive sleep apnoea syndrome. There is close relationship between adenoids and possible middle ear pathology leading to conductive deafness. Objective: To find out the outcome of surgery regarding clinical features and hearing status in children with adenoids. Methods: This hospital based prospective study was conducted at the Department of Otolaryngology& Head-Neck Surgery, Shaheed Suhrawardy Medical College & Hospital, for a period of 6 months following approval from IRB. Patients having enlarged adenoids with or without OME of 3-12 years and both sex group were approached for inclusion of the study. Informed written consent was taken from the guardian. Proper surgical intervention was chosen according to condition of the child. Before and after intervention, data were collected by the researcher himself. Data were recorded into the case record form. Following collection, data were analyzed by the SPSS 26 (SPSS Inc, Chicago, IL, USA). Results: Among 100 patients, 66% were males and 34% were females. Mean age was 7.2±2.34 SD (years). Of all, 60% underwent adenoidectomy (AT), 20% underwent adenoidectomy with myringotomy (AM), and remaining 20% underwent adenoidectomy with myringotomy with grommet insertion (AMG). The PTA findings (baseline) of adenoidectomy, adenoidectomy with myringotomy, and adenoidectomy with myringotomy with grommet insertion group were 15.466±1.395, 37.8±3.349 and 38.2±3.548 db, respectively. Similarly, significant improvement was noticed in all of the three groups as evidenced by PTA value in three groups were 11.91±1.12, 18.65±.933 and 17.45±1.31 db, respectively (p<0.05). Improvements in PTA among different groups also showed significant changes following operation (p<0.05). Conclusion: Clinical improvement are noticed following surgical intervention in both ............
Evaluasi User Experience pada Aplikasi Discord Mobile sebagai Media Komunikasi menggunakan UEQ dan Usability Testing
Authors: Akhdhar Mohammad Rafi Fadhillah
Published: July 2024

This study aims to evaluate the user experience and usability of Discord mobile application through User Experience Questionnaire (UEQ) and Usability Testing. The research method used a mixed method approach with quantitative and qualitative analysis. Data was collected from 50 respondents aged 15-27 who have used Discord Mobile for more than six months. The evaluation results show UX quality dimensions such as attractiveness, efficiency, perspicuity, dependability, stimulation, and novelty from the user's point of view. Data analysis was conducted using UEQ Data Analysis Tools and feedback from usability testing. The findings from this study can be used as a reference to improve the user experience and usability of the Discord Mobile app in the future.
Implementasi Sistem Informasi Dengan Menggunakan Enterprise Resource Planning (ERP) Odoo di PT. XYZ Purwodadi
Authors: Rusmanto Didik Eko , Zakariyya Ahmad Yusuf , Nurrahman Syafran
Published: July 2024

In the current technological era, information technology has an important role in the business world. However, there are still companies that have not utilized information technology. PT. XYZ Purwodadi, is a motor vehicle sales company (dealer) that still does all work manually. This has resulted in problems for the Company, especially in terms of obtaining information, where it takes longer because the data contained in the Company has not been integrated. Then, there is the possibility of problems resulting from negligence by employees, such as data that is forgotten to be entered into the Company's data records. The Enterprise Resource Planning program was created to try to overcome the problems that occurred at PT. To overcome the problems found in the Company, a Critical Path Method (CPM) function was created to support the Company's business processes in carrying out project management. To measure the success of implementing the Odoo ERP program, user satisfaction analysis was carried out using the Doll and Torkzadeh (1998) method. From the results of the analysis of the implementation of the Odoo ERP program in the Company, it can be concluded that the Odoo ERP program has had a good impact on fulfilling the Company's needs well and quickly.
EVALUASI TINGKAT KEPUASAN PELAYANAN KEFARMASIAN PADA PASIEN BPJS RAWAT JALAN DI RUMAH SAKIT UMUM DAERAH RATU ZALECHA MARTAPURA DENGAN MENGGUNAKAN METODE CUSTOMER WINDOW QUADRAT (CWQ)
Authors: Napisah Siti , Muthaharah Mustika , Mulyani Tuty , Wulandari Putrie , Wirahadikesuma Ikhwan
Published: July 2024

Penilaian kepuasan pasien merupakan tanggapan konsumen terhadap pelayanan yang diberikan sesuai dengan kebutuhan dan harapan pasien terhadap pelayanan kefarmasian. Tujuan dari penelitian ini adalah untuk mengetahui tingkat kepuasan pelayanan kefarmasian pada pasien BPJS rawat jalan di RSUD Ratu Zalecha Martapura dan untuk mengetahui dimensi – dimensi yang mempengaruhi kualitas pelayanan kefarmasian yang akan diperbaiki untuk kepuasan pasien dengan menggunakan metode customer window quadrat. Jenis penelitian kuantitatif dengan desain deskriptif cross sectional dengan teknik purposive sampling. Hasil penelitian ini menunjukkan bahwa tingkat kepuasan pada masing-masing dimensi mutu yaitu Tangible 92,73 (sangat puas), Responsiveness 87,63 (sangat puas), Reliability 90,83% (sangat puas), Assurance 87,58% (sangat puas), Empaty 95,71% (sangat puas). Berdasarkan hasil analisis CWQ maka terdapat 1 item pernyataan yang menjadi prioritas utama dalam perbaikan yang harus dilakukan apotek yaitu pada kuadran A. Prioritas perbaikan pada item 2 “Kecepatan waktu dalam menyerahkan obat”.
Full Text Volume 11 Number 2 July 2024
Authors: Hospital Kariadi General
Published: July 2024

Full Text Volume 11 Number 2 July 2024
COW TRAFFIC DESIGNS IN BARNS WITH AUTOMATIC MILKING SYSTEMS: ADVANTAGES, DISADVANTAGES AND DIFFERENCES
Authors: Busanello Marcos
Published: July 2024

This study describes the most common traffic systems in barns for lactating dairy cows milked in automatic milking systems (AMS). It outlines seven cow traffic designs, each featuring a basic floor plan, taking into account one robot or AMS per barn and considering a maximum system capacity (> 60 cows/AMS). The study describes the advantages and disadvantages of free, milk-first and feed-first traffic and the differences between forced and guided cow traffic designs. Some research data are also shown to emphasize the theoretical concepts included in this document. The main difference is that free cow traffic tends to milk a lesser number of cows than milk-first and feed-first cow traffic designs but warrants more freedom for the cows. However, free cow traffic design increases the number of refusals (cows visiting the AMS without milking permission), leading to system inefficiency. Guided traffic designs emerge as the most efficient, milking more cows throughout the day while reducing the need to fetch cows and overall labour. When operating at full cow capacity, guided cow traffic designs are recommended.
FLEXIBLE DUODENAL MONOCANNULA OF THE NATIONAL AGRICULTURAL AND FOOD CENTRE DESIGN FOR THE DETERMINATION OF INTESTINAL NUTRIENT DIGESTIBILITY IN CATTLE
Authors: Rajsky Matus , Szakács Juraj , Formelová Zuzana , Mlyneková Zuzana
Published: July 2024

Research in physiology of ruminant nutrition using the in sacco and mobile bag methods and developing and testing of a duodenal cannula of our own construction including our own surgical application in cattle, led to the intellectual property protection. The duodenal monocannula for determination of nutrient intestinal digestibility in cattle, designed by the National Agricultural and Food Centre (NPPC, Slovak Republic), has been registered by European Union intellectual property office, as a Registered Community Design. The innovativeness of the technical design of the "NPPC cannula" lies in the fact that the cannula is made of one piece of a straight tube with an inner diameter of 22 mm. The tube is smooth, with no additional extensions and glued parts. The operation does not require ligation of the bowel with an arterial prosthesis or a polyurethane felt. The dimensions of the cannula allow the use of the mobile bag method without any problems. The vinyl chloride emulsion was designed to polymerize at the lower temperature, than has been currently used in this procedure (130 °C), and the end used for fixation in the intestine could be shaped after immersion in warm water. During the growth of the animals, the tube length can be prolonged to adapt to the duodenal size. As a result, the life of cannulated animals can be extended without age limitation.
RELATO DE CASO DE ABUSO SEXUAL INFANTIL NO HOSPITAL UNIVERSITÁRIO GAFFRÉE E GUINLE
Authors: Lopes Lima Rocha Matheus , Rosa Leite Bianca , Santana Cunha João Vitor , De Carvalho Gomes Pedro Henrique
Published: July 2024

Introdução: o abuso sexual infantil é caracterizado quando uma criança é exposta a toques inapropriados, comentários lascivos ou outra forma de exploração sexual, constituindo fator de risco para diversos problemas de saúde, tanto na infância quanto na adolescência. A maior parte dos abusos se dá com vítimas é do sexo feminino, sobretudo dos 10 aos 14 anos, dentro do ambiente domiciliar e por pessoas conhecidas. Objetivo: relatar um caso de abuso sexual infantil e fomentar a discussão acerca do tema. Método: os dados foram obtidos através de entrevistas da paciente, exame físico, e revisão da literatura. Considerações finais: é fundamental sustentar um olhar ativo para investigar as suspeitas de abuso sexual. Torna-se crucial que as intervenções sejam feitas de modo multidisciplinar, pensando em conjunto com outras áreas, como à assistência social, de modo que possamos modificar o panorama atual.
DIAGNÓSTICO E TRATAMENTO DA INSUFICIÊNCIA CARDÍACA: UMA REVISÃO DE LITERATURA
Authors: Rodrigues de Queiroz Ronara , Valadares Nolêto Damasceno Thais , Henrique Santana Amanda , Isabelle Alves Dantas Raissa , Eduarda Dias Arouca Maria , Matos Bezerra Vitória , Edite Félix Barbosa Maria , De Oliveira Matheus , Jorge Sales Lopes Cândido Ribeiro Victor , Bonamim Fiorilli Roberta , De Carvalho Carneiro Eduardo , Bernegozzi Bessa Vinicius
Published: July 2024

Este artigo tem por objetivo avaliar os aspectos clínicos da insuficiência cardíaca realizada nos últimos cinco anos. Revisão integrativa no banco de dados da BVS, LILACS, SciELO, PubMed de trabalhos publicados entre 2020 e 2024, combinando os descritores "nefrolitíase", "diagnóstico" e "tratamento" ao descritor booleano "AND". A Insuficiência Cardíaca é uma síndrome de diagnóstico clínico, baseado em achados de história clínica, exames físicos e complementares. Entre as ferramentas que auxiliam o diagnóstico estão os escores diagnósticos, a radiografia de tórax, o eletrocardiograma de repouso, a ecocardiografia e a dosagem sérica de BNP ou a sua porção N-terminal. O objetivo deste tratamento é a melhora clínica, o aumento da capacidade funcional e a redução de comorbidades, podendo ser utilizados de forma combinada quando apropriado.
Glass in fine art: Contemporary approaches in the 21st century in the Portuguese panorama
Authors: Almeida Teresa
Published: July 2024

Art glass is a pioneering form of art that is open to investigations and distinct applications. The technological developments in science combined with novel esthetic concepts allow new artistic interpretations of this material that can be transparent, translucid, crystal, and opaque. Glass is an art material prevalent in Portugal territory, which has been historically connected particularly with glassblowing and stained glass. Many Portuguese artists are now integrating glass into the conception of their art pieces. This article aims to present the panorama of Portuguese contemporary glass and the importance of education programs that have emerged in the past years contributing to the increase of artists working with glass as a fine art material. Research conducted in universities, as well as numerous synergistic projects, also represents key factors leading to the increased convergence between art, science, and the production of original materials. This paper also presents works from young-generation artists, projects, and events.
In silico investigation of lipid-based compounds implicated in amyotrophic lateral sclerosis
Authors: Fatoki Toluwase Hezekiah , Olabayode Saliu Ibrahim , Balogun Tosin Christianah , Oyebiyi Oyeleke Ridwan , Ogunleye Samuel Oluwaseun , Akereja Ayotunde Kehinde , Iyanda Abisola Eunice , Lukman Rukayat Omowumi , Ogunleye Oluwaseun Oluwatosin , Oyewo Faeezah Gold , Aigbokhaevho Enakhamiele Comfort , Adebayo Yetunde Ramat , Akerele Blessing Odunayo , Oladimeji Ayotunde Tope , Obata Bukunmi Oluwasayo , Yekini Fatima Timileyin
Published: July 2024

Amyotrophic lateral sclerosis (ALS) is a fatal, currently incurable neurodegenerative disease that progressively affects the upper motor neurons in the brain and lower motor neurons in the spinal cord. A significant portion of patients exhibit abnormalities in lipid metabolism, which appear to contribute to denervation and subsequent motor neuron degeneration. This study aimed to computationally identify lipid-based compounds associated with ALS and elucidate their pathological and therapeutic roles to facilitate effective ALS diagnosis and treatment. The methodologies employed encompassed rational database searches, pharmacokinetic and target predictions, as well as docking and molecular dynamics simulations (MDS). The findings from the disease-to-lipids analysis identified 20 lipid compounds correlated with ALS, primarily categorized as potential inhibitors within the functional classes of vitamins, antibiotics, organic acids, and phytochemicals. Pharmacokinetic predictions revealed that only four compounds exhibited permeability across the blood–brain barrier, namely 4-hydroxynonenal, resveratrol, rotenone, and valproic acid. Docking simulations indicated the highest binding affinity for 4-hydroxynonenal with alkaline ceramidase 2 (−4.516 kcal/mol), resveratrol with carbonic anhydrase 6 (−7.070 kcal/mol), rotenone with cytochrome P450 2C19 (−7.378 kcal/mol), and valproic acid with glutamate carboxypeptidase 2 (−5.629 kcal/mol). Furthermore, MDS and molecular mechanics/generalized born surface area calculations demonstrated the stability and binding energies of the complexes under simulated physiological conditions. In summary, further investigation is warranted to explore the synergistic effects of resveratrol and valproic acid in ALS, the mechanisms underlying 4-hydroxynonenal adduct-assisted aggregate formation of certain enzymes in ALS, and the impact of prolonged human exposure to rotenone from marine food sources (such as fish) on the development of ALS.
Advancements in 3D bioprinting for precision medicine: Enhancing patient-derived organoids and extracellular vesicle applications in inflammatory diseases
Authors: Sung Park Hyun , Han Park Jae , Oh Mi-Kyung , Yu Kyung-Rok
Published: July 2024

The integration of three-dimensional (3D) bioprinting with cultures of patient-derived organoids represents a transformative advancement in precision medicine, enabling the creation of anatomically accurate and physiologically relevant tissue models. These models are pivotal for personalized disease modeling, therapeutic development, and regenerative medicine. 3D bioprinting enhances the structural and functional fidelity of organoids, thereby improving their application in drug screening and disease intervention strategies. Additionally, this technology facilitates the study of extracellular vesicles (EVs) released from patient-derived organoids (PDOs), which are rich in bioactive molecules and play crucial roles in modulating immune responses. Particularly in chronic inflammatory conditions, these organoid-derived EVs are instrumental in cellular communication and improve our understanding of disease mechanisms beyond traditional biopsies. This review focuses on the latest developments in 3D bioprinting techniques for organoids and EVs, highlighting their potential to revolutionize the treatment of inflammatory diseases through precision medicine.
Faktor-Faktor Yang Mempengaruhi Usahatani Kopi Robusta Di Kecamatan Cibal Barat
Authors: Febronia Cristiana Yunita Ndiwa  , Samur Eldis Suasana , Morse Febrianus , Andur Emilia Kurniati , Cordanis Astried Priscilla
Published: July 2024

Kopi merupkan salah satu komoditas yang memiliki nilai ekonomi yang tinggi Produktivitas kopi yang baik ditunjang oleh penggunaan faktor-faktor produksi yang efektif dan efisien. Penelitian ini dilakukan dengan tujuan untuk mengetahui faktor-faktor apa saja yang mempengaruhi rendahnya produktivitas kopi. Penelitian ini dilakukan di Kecamatan Cibal Barat dengan dua desa specimen yaitu Desa Bangka Ara dan Desa Lenda, dengan pertimbangan kondisi geografis serta sosial masyarakat yang sangat potensial untuk dikembangkan usaha ini. Sampel yang diambil sebanyak 34 responden dari total populasi 210. Metode analisis yang digunakan adalah uji statistic dengan fungi produksi Cobb douglass. Berdasarkan hasil analisis didapatkan bahwa faktor produksi luas lahan ternyata berpengaruh positif dan signifikan terhadap produksi kopi. Selain itu juga terdapat pengaruh inefisiensi seperti umur tanaman dan jumlah pohon. Penggunaan tenaga kerja juga nyatanya berdampak negative dan tidak siginifikan dengan nilai -0.127.
Respon Pertumbuhan Vegetatif Tanaman Cabai Merah (Capsicum annum L.) terhadap Pupuk Kotoran Sapi dan Konsentrasi Oligokitosan
Authors: Nor Faizal  , Muhammad Noor Ariefin
Published: July 2024

Budidaya tanaman cabai di tanah vertisol menghadapi kendala berupa rentan terhadap penyakit keriting, pupuk kimia NPK dan kemampuan menyerap air yang rendah, hal ini dapat diatasi dengan pemberian bahan organik. Penelitian ini bertujuan untuk mengetahui pengaruh pupuk kotoran sapi dan oligokitosan terhadap pertumbuhan tanaman cabai merah ditanah vertisol. Penelitian ini telah dilaksanakan di Kebun Percobaan Fakultas Pertanian UPN “Veteran” Yogyakarta, Wedomartani, Ngemplak, Sleman, Yogyakarta pada bulan Juni sampai bulan Agustus 2019. Metode yang digunakan adalah percobaan lapangan di dalam polybag dengan menggunakan Rancangan Acak Lengkap (RAL) yang terdiri atas dua faktor, diulang 3 kali dan setiap unit percobaan terdapat 6 tanaman. Faktor pertama tanah vertisol:pupuk kotoran sapi masing-masing K1 (1:1), K2 (1:2), dan K3 (1:3). Faktor kedua konsentrasi oligokitosan M1(1000 ppm), M2 (2000 ppm), dan M3 (3000 ppm). Data pengamatan di analisis menggunakan uji Analysis of Varians (ANOVA) pada jenjang nyata 5% dan kontras orthogonal, dan yang terdapat beda nyata dilanjutkan dengan Dumcan Multiple Range Test (DMRT) pada taraf 5%. Berdasarkan hasil penelitian dan analisis dapat disimpulkan bahwa dari setiap perlakuan perbandingan pupuk kandang sapi dan konsentrasi tidak terdapat beda nyata pada parameter tinggi tanaman (cm), jumlah daun (helai), jumlah cabang dan diameter batang (mm).
Efisiensi Serapan Hara N, P, K terhadap Pertumbuhan dan Hasil Padi Gogo Varietas IPB 9G
Authors: Djami Adi Defiyanto , Iskandar Lubis  , Suwarto
Published: July 2024

Tujuan penelitian adalah untuk mengetahui pengaruh serapan hara N, P, K terhadap pertumbuhan dan hasil padi gogo varietas IPB 9G. Penelitian terlaksana di bulan Maret-Juni 2018 di Lahan Percobaan Sawah Baru-IPB. Rancangan yang digunakan: Rancangan Kelompok Lengkap Teracak (RKLT) diulang tiga kali. Dosis pupuk 0, 50, 100, 150, 200% (100% N = 200 kg Urea ha-1, 100% P = 100 kg SP36 ha-1, 100% K = 100 KCl ha-1. Aplikasi pupuk N diberikan tiga tahap: 40% saat tanam, 30% saat 4 MST, 30% saat 8 MST. Pupuk P dan K diberikan 100% saat tanam. Peningkatan dosis pupuk N 0-200% berpengaruh terhadap efisiensi serapan, efisiensi penggunaan N, bobot gabah per rumpun, produktivitas. Peningkatan dosis pupuk P 0-200% berpengaruh terhadap serapan hara, efisiensi serapan, efisiensi penggunaan P. Peningkatan dosis pupuk K 0-200% berpengaruh terhadap efisiensi serapan, efisiensi penggunaan K, bobot gabah per rumpun, produktivitas. Perlakuan dosis pupuk P 0-200% berpengaruh terhadap serapan hara pada fase panen.
Pendugaan Mutu Benih dengan Teknologi Near Infrared (NIR)
Authors: Jawak Gani
Published: July 2024

Near infrared (NIR) merupakan metode nondestruktif yang dapat dikembangkan dalam pengujian mutu benih. Penelitian ini dilakukan untuk menduga mutu benih dengan memanfaatkan NIR. Benih yang digunakan adalah benih bayam dan kacang tanah viabel dan nonviabel. Benih nonviabel diperoleh dengan merendam benih dalam etanol 96% (1 menit) dan dioven (60 °C selama 24 jam). Pengujian dengan NIR dilakukan dengan meletakkan benih dalam cawan petri pada NIR instrument sebanyak tiga kali. Hasil pembacaan dilihat pada komputer. Pengujian laboratorium untuk mengetahui DB, PTM, dan KA. Kacang tanah dan bayam masing-masing ditanam dengan metode UKDdp dan UDK menggunakan empat ulangan masing-masing 25 benih. Hasil penelitian menunjukkan bahwa nilai reflektan benih kacang tanah viabel pada panjang gelombang 1000-2500 nm lebih rendah dibandingkan nonviabel. Nilai reflektan benih bayam viabel pada panjang gelombang 1000-1300 nm lebih tinggi dibandingkan benih nonviabel sedangkan pada panjang gelombang > 1300 nm nilai reflektannya lebih rendah. KA dan PTM benih kacang tanah viabel berbeda nyata dengan benih nonviabel sedangkan daya berkecambanya tidak berbeda nyata. KA, DB, dan PTM pada bayam viabel berbeda nyata dibandingkan dengan nonviabel. Pengujian mutu benih dengan memanfaatkan nilai reflektan NIR pada kacang tanah sejalan dengan hasil pengujian laboratorium dan dapat dijadikan alternatif dalam pengujian mutu benih secara non destruktif sedangkan pada bayam masih membutuhkan kajian lebih lanjut.
SYSTEM MONITORING PARAMETER UTAMA PADA RUANGAN KERJA TRANSFORMATOR DENGAN BANTUAN KOMPUTER
Authors: Sofwan A. , Prasetyo M.G.
Published: July 2024

Makalah ini memaparkan tentang konsep Sistem monitoring kondisi ruangTransformator dengan bantuan komputer. Dua parameter utama kondisi ruang transformatorini adalah suhu dan kelembaban. Dengan sistem monitoring ini dimaksudkan untukmembantu mengontrol dan memonotoring suhu kerja ruangan pada transformator, dimanapada aplikasinya digunakan ruangan tetutup. Pada sistem monitoring dan kelembaban inimenggunakan komponen utama yaitu : SHT 11 sebagai sensor suhu dan kelembaban, max232 sebagai serial koneksi, ATmega 8 sebagai kontrol program dan akuisisi data dandigunakan komputer serta aplikasi utama Borland Delphi 7 sebagai sarana program Visual.Dalam pengujian monitoring suhu operasi ruangan transformator antara 290C sampai 330Cdan kelembaban antara 67%RH sampai 56%RH, didapatkan hasil eror rata-rata darikeempat pengujian, eror program Low level pada kelembaban adalah 0,805% dan untukpembacaan temperatur error oleh program low level dengan error rata-rata 0,07%. Programlow level language tidak berpengaruh terhadap kemampuan sensor SHT11.
Simulasi Sistem Navigasi Berbasis-Perilaku dan Kontroler PID pada Manuver Mobile Robot
Authors: Supriyadi Edy , Abdikar Aktsar , A.S Nizar Rosyidi
Published: July 2024

Merancang dan mengimplementasikan algoritma kendali behavior based (berbasis perilaku) pada mobile robot beroda tipe differential steering dan kontroler PID (Proporsional, Integral, Diferensial) pada manuver robot ini. Tugas robot ini adalah menyusuri dan mencari target yang diletakan secara acak (random) pada suatu citra (environment) yang terdiri dari dua: citra sederhana dan citra labirin. Kendali berbasis perilaku menggunakan modul-modul perilaku yang bekerja secara bersamaan membentuk perilaku robot yang ingin dicapai.Masing-masing perilaku sifatnya independen, memiliki hubungan langsung dengan sensor dan aktuator. Selain menerapkan kendali berbasis perilaku laporan penelitian ini juga merancang dan mengimplementasikan kontroler PID pada manuver robot maze terhadap jarak dinding citra. Kontroler PID bertujuan untuk memuluskan pergerakan robot saat menelusur ruangan/lorong citra dan labirin.Dengan bantuan kontroler PID robot maze mampu bermanuver dengan aman, halus, responsif dan cepat. Hasil parameter kontroler PID yang dicapai dari penelitian laporan penelitian ini diperoleh dari hasil tuning eksperimen metode Trial and Error dengan hasil Kp = 17, Ki = 5 dan Kd = 0 pada citra sederhana dan Kp=10, Ki= 2, dan Kd=0 pada citra labirin.
ANALISA PERFORMANSI TRAFIK INTER-MSC UNTUK MENGATASI HIGH-OCCUPANCY PADA SISTEM GSM
Authors: Gafar Mufti , Pratama Aji Bayu
Published: July 2024

Occupancy inter-MSC merupakan salah satu parameter trafik yang dapat menggambarkantingkat kinerja beban terhadap kanal yang tersedia dalam suatu interkoneksi antara dua MSC.Semakin tinggi nilai occupancy pada suatu interkoneksi, semakin efisien pula penggunaan kanal padainterkoneksi tersebut. Akan tetapi, tingginya occupancy juga berpotensi terjadinya panggilan yangterbuang. Agar dapat menurunkan high-occupancy, interkoneksi tersebut harus dianalisa di keduaMSC. Analisa tersebut mencakup parameter trafik seperti call answered, incoming traffic, outgoingtraffic dan holding time sehingga nantinya berkorelasi dengan besar occupancy pada interkoneksitersebut. Dengan menargetkan occupancy yang ingin dicapai, akan didapat banyaknya kanal yangharus dialokasikan.Setelah dianalisa, terdapat perbedaan jumlah kanal yang harus ditambahkan dimasing-masing MSC. Pada kasus ini, MJK06 harus ditambahkan 14 E1 dan TDJK4 harus ditambah15E1. Maka yang dijadikan acuan adalah jumlah kanal yang paling banyak, yaitu menambahkan 15E1 di kedua sisi MSC. Hal ini dilakukan karena menganggap TDJK4 berada pada kondisi worstcase.Selanjutnya high-occupancy dapat dikurangi dengan cara dilakukan penambahan kanal padainterkoneksi tersebut. Secara praktis, hal tersebut dapat dilakukan dengan menggunakan softwareinterface yang terhubung dengan perangkat MSC.
MENINGKATKAN PERCAYA DIRI ATLET INTELEKTUAL RENDAH PADA CABANG OLAHRAGA OPEN-SKILL MELALUI LATIHAN KOGNISI
Authors: Bayani Syifa Nur , Komarudin Komarudin , Saputra Mochamad Yamin , Novian Geraldi
Published: July 2024

Kondisi Psikologis merupakan hal penting yang harus di perhatikan pelatih dalam pertandingan atau latihan. Atlet seringkali mengalami gangguan psikologis. Maka dari itu kemampuan psikologis yang baik sangat diperlukan oleh atlet terutama percaya diri. Self-Confidence merupakan suatu sikap atau keyakinan atas kemampuan diri sendiri, sehingga dalam tindakannya tidak terlalu cemas dan merasa bebas untuk melakukan hal-hal yang sesuai dengan keinginannya. Dimana ke-dua treatment yang diberikan baik latihan life kinetik dan Brain Gym keduanya memerlukan kepercayaan diri yang baik. Penelitian ini bertujuan untuk mengetahui pengaruh latihan kognisi terhadap percaya diri atlet intelektual rendah pada cabang olahraga open-skill. Metode yang digunakan dalam penelitian ini adalah metode eksperimen dengan diberikan perlakuan. Menggunakan desain penelitian two group petest-posttest control group design. Sampel dalam penelitian ini merupakan atlet cabang olahraga kategori open-skill yang terdiri dari Unit Kegiatan Mahasiswa (UKM). Dalam mengukur intelektual atlet menggunakan instrument penelitian Advanced Progressive Matrices (APM), dan untuk mengukur percaya diri menggunakan Sport Confidence Questionnaire (SCQ). Hasil penelitian menunjukan bahwa model latihan kognisi memberikan pengaruh yang signifikan terhadap peningkatan percaya diri atlet intelektual rendah pada cabang olahraga open-skill. Tetapi tidak terdapat perbedaan antara latihan life kinetik dan brain gym terhadap percaya diri atlet intelektual rendah pada cabang olahraga open-skill.
PENGARUH PEMBERIAN INFORMASI METODE RICE TERHADAP TINGKAT PENGETAHUAN PENANGANAN DINI CEDERA PADA PEMAIN FUTSAL
Authors: Liputo Gusti Pandi , Antu Mihrawaty S , Yusuf Nur Ayun R. , Wulansari Ika
Published: July 2024

Cedera kaki terkilir merupakan salah satu trauma yang disebabkan oleh tekanan rendah yang berulang-ulang dalam jangka waktu yang lama. Tujuan penelitian ini adalah untuk mengidentifikasi dan menganalisa pengaruh Metode Rest, Ice, Compression dan Elevation (RICE) terhadap tingkat pengetahuan dan penanganan dini cedera terkilir pada pemain Futsal. Jenis penelitian ini merupakan jenis penelitian Pre-eksperimental dengan rancangan one-group pre-post test design. Sampel pada penelitian ini adalah pemain Futsal dengan tehnik Accidental Sampling sebanyak 30 responden yang memenuhi kriteria inklusi. Alat ukur yang digunakan adalah kuisioner pengetahuan yang dikembangkan oleh peneliti (telah dilakukan uji valid dan reliable). Hasil penelitian sebelum dilakukan Metode rice pada pemain Futsal kategori kurang sebanyak 30 responden (100%), setelah diberikan informas Metode Rice dalam bentuk media seperti leaflet keseluruhan pemain Futsal ialah baik sebanyak 30 responden (100%). Uji Analisis statistik Wilcoxon. di dapatkan nilai p=0,000 0,05. Kesimpulan pada penelitian ada pengaruh antara Metode RICE terhadap tingkat pengetahuan penanganan dini cedera pada pemain Futsal. Metode RICE direkomendasikan untuk dikuasai oleh seluruh pemain Futsal sebagai tindakan awal dalam mengatasi cedera.
PENGARUH CORE STABILITY EXERCISES TERHADAP KESEIMBANGAN DINAMIS PEMAIN BOLA VOLI
Authors: Azzahra Zahwa , Purnamasari Ira , Mustaqim Ridha
Published: July 2024

Keseimbangan dinamis adalah komponen kondisi fisik yang dapat mengefesiensikan gerak tubuh atlet. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh core stability exercises terhadap keseimbangan dinamis pemain bola voli. Metode yang digunakan dalam penelitian ini adalah metode eksperimen. Sampel penelitian ini berjumlah 16 atlet volleyclub Wicitrawirya, dengan pemilihan teknik purposive sampling sebagai penentuan sampel dan kriteria tertentu. Instrumen yang digunakan dalam penelitian ini adalah modified bass test. Teknik analisis data yang digunakan yaitu Uji Normalitas, Uji Homogenitas, dan Uji Paired Sample T-test. Hasil dari penelitian ini menyatakan bahwa core stability exercises memiliki pengaruh yang signifikan terhadap keseimbangan dinamis dengan peningkatan 22% dari hasil pre-test dan post-test yang diberikan treatment selama 12 kali pertemuan. Kesimpulan dari penelitian ini adalah terdapat pengaruh yang signifikan core stability exercises terhadap keseimbangan dinamis pemain bola voli.
Metformin in COVID-19: a magical role beyond the hyperglycemia
Authors: Chaubey Gaurav Kumar , Dilawari Rahul , Modanwal Radheshyam , Talukdar Sharmila , Dhiman Asmita , Raje Manoj
Published: July 2024

Coronavirus disease-2019 (COVID-19) has emerged as an aggressive viral infection in the last few years. Initially reported in the Wuhan area of the People’s Republic of China, it soon emerged across the globe. Researchers confront a worrying situation to rapidly develop effective strategies to combat this novel infection and its long-term aftereffects. To date, there have been myriad reports ranging from the repurposing of the classical antimalarial drug hydroxychloroquine to several other antiviral and anti-bacterial agents like remdesivir, favipiravir, and most recently azithromycin, which has entered clinical use in many countries for combating COVID-19 infections. Several studies have highlighted the nexus between COVID-19-associated morbidity and diabetes in a wide-ranging class of subjects ranging from pediatric cases to adults and patients with other co-morbidities. Metformin is a mainstay in the treatment of type 2 diabetes (T2D). It is safe, inexpensive, and effective and does more than merely control blood sugar levels. Important metabolites that encourage blood clotting and inflammation are also suppressed by metformin. Pro-inflammatory molecules are linked to obesity and T2D. Both are major risk factors for aggravated COVID-19. These characteristics gave rise to a hypothesis that metformin may find use as an efficacious treatment for COVID-19 especially if it decreases the inflammatory molecules that fuel the COVID-19 virus-induced effects. In this review, we attempt to elucidate the role of classical anti-diabetic medicine metformin in the treatment of COVID-19 infections by highlighting the pharmacological role of this drug during elevated glucose levels and insulin resistance. We examine how COVID-19 has correlations to diabetic physiology and thereby the possibility of repurposing metformin for COVID-19 treatment.
Numerical Investigation of Nanofluid’s Heat Transfer Performance in Passive Residual Heat Removing System of AP1000 Nuclear Reactor
Authors: Ponkty Mantasha , Puja Anamika , Mollah Abdus Sattar
Published: July 2024

The Passive Heat Removal system (PHRS) is designed to remove the residual heat from the core in case of a station blackout, failure of emergency core cooling system, or failure of feedwater supply through the Passive Residual Heat Removal Heat Exchanger (PRHR HX). PRHR HX consists of a C-shaped tube bundle as a heat exchanger and the In-Containment Refueling Water Storage Tank (IRWST) as a heat sink. A temperature distribution of this passive heat removal system of an AP1000 Reactor is generated using COMSOL Multiphysics and the heat transfer coefficient is calculated to illustrate the effectiveness of the PHRS. A comparison of the heat transfer coefficient between the IRWST filled with water and nanofluid has been generated using the PRHR HX design. Thermophysical properties of nanofluids have been calculated in the process of calculating the heat transfer coefficient. Numerical results show the difference in temperature reduction of Al2O3, TiO2, and Ag as opposed to water in the IRWST. Time-dependent heat conduction of water and nanofluid results contribute to the effective analysis of passive heat removal systems and provide information for the safe operation of AP1000 reactors. By the end of 2024/2025, two VVER-1200 power stations with a combined capacity of 2400 MW will be operating in Bangladesh. For safety and licensing reasons, heat transfer simulation of VVER-1200 can be performed using COMSOL software.
Exponential Ratio Class of Estimators of Finite Population Mean Using Deciles of an Auxiliary Variable
Authors: Adejumobi Awwal , Yunusa Mojeed Abiodun , Abubakar Kabiru , Rashida Abdulrahman
Published: July 2024

Practitioners of survey sampling have been working to reduce bias and increase efficiency in the estimation of finite population parameters. The present work aims at developing an exponential ratio class of finite population mean estimators with deciles of an auxiliary variable. Using the Taylor's series technique, the mean square error (MSE) of the developed estimators was obtained up to the first order of approximation. The study's suggested estimators outperform competing estimators, according to the findings of a numerical analysis that was done on them in comparison to the existing estimators that were taken into consideration.
Implementation and protection of a person's subjective corporate right to information
Authors: Hevko Volodymyr
Published: July 2024

The corporate right of a participant of a legal entity to receive information about a legal entity and its activities is a key subjective corporate right of a person, without the implementation of which and in the event of its violation, all other subjective corporate rights of a person will also suffer adverse consequences. Therefore, the study of the conditions for the realization of a person's subjective corporate right to information, as well as the issues of its effective protection in the event of a violation, is quite relevant at the present time.

Currently, the legal definition and legal regulation of the grounds and procedure for the implementation and protection of a person's subjective corporate right to receive information is not entirely satisfactory and undisputed. Yes, we have a contradictory understanding of the right to receive information as a corporate right in Article 96-1 of the Civil Code of Ukraine. The procedure for implementing this right in other specialized corporate legislative acts is not sufficiently regulated. In many cases, corporate disputes on this issue arise precisely because of different interpretations of legislation or gaps in it. Nor does the judicial practice of resolving these disputes provide answers to all problematic issues.

Also, even though due attention was paid to this issue in science your time, however, due to constant changes in corporate legislation, the implementation and protection of a person's subjective corporate right to information require constant additional study and understanding.

In the article, based on the analysis of the content of a person's subjective corporate right to receive information about the «corporation», it is determined that a person's corporate right to information is one of the significant ones – one without which a person would not be able to effectively exercise all his other subjective corporate rights. An effective way to protect the right of a participant (shareholder, member) of the «corporation» to receive information about the activities of the «corporation» is to induce the «corporation» in court to perform actions by the «corporation» – provide certain information.

Key words:information, corporate right to information, implementation of the right to information, effective way of protecting the corporate right to information.