bluuebunny/crossref_metadata_2025 huggingface dataset:
Low Resolution Face Recognition Using Generative Adversarial Network (GAN)
Authors: Martin Howard , - Suharjito
Published: December 2020

Face recognition has a lot of use on smartphone authentication, finding people, etc. Nowadays, face recognition with a constrained environment has achieved very good performance on accuracy. However, the accuracy of existing face recognition methods will gradually decrease when using a dataset with an unconstrained environment. Face image with an unconstrained environment is usually taken from a surveillance camera. In general, surveillance cameras will be placed on the corner of a room or even on the street. So, the image resolution will be low. Low-resolution image will cause the face very hard to be recognized and the accuracy will eventually decrease. That is the main reason why increasing the accuracy of the Low-Resolution Face Recognition (LRFR) problem is still challenging. This research aimed to solve the Low-Resolution Face Recognition (LRFR) problem. The datasets are YouTube Faces Database (YTF) and Labelled Faces in The Wild (LFW). In this research, face image resolution would be decreased using bicubic linear and became the low-resolution image data. Then super resolution methods as the preprocessing step would increase the image resolution. Super resolution methods used in this research are Super resolution GAN (SRGAN) [1] and Enhanced Super resolution GAN (ESRGAN) [2]. These methods would be compared to reach a better accuracy on solving LRFR problem. After increased the image resolution, the image would be recognized using FaceNet. This research concluded that using super resolution as the preprocessing step for LRFR problem has achieved a higher accuracy compared to [3]. The highest accuracy achieved by using ESRGAN as the preprocessing and FaceNet for face recognition with accuracy of 98.96 % and Validation rate 96.757 %.
TİCARİ SÖZLEŞMELERİN YABANCI DİLDE HAZIRLANMASINA BAĞLANAN HUKUKİ SONUÇLAR
Authors: ÖZDEMİR Semih Sırrı
Published: December 2020

805 sayılı İktisadi Müesseselerde Mecburi Türkçe Kullanılmasına Dair Kanun, sözleşmelerde yabancı dil kullanımına ilişkin getirdiği sınırlamalar ve bunlara ilişkin müeyyidelerle, Türk ticaret hukuku açısından özel bir önem taşımaktadır. Özellikle, düzenlemenin kapsamı ve müeyyidenin borçlar hukuku açısından sonuçlarının tayininde yaşanan belirsizlik, konunun tartışmalı yönlerine işaret etmektedir. Bu konuda, “sözleşmedeki lehe nitelikteki maddelere dayanılamaması” genel kabul gören yaptırımdır. Ancak, Kanun’un uygulanması açısından birbirinden farklılaşan yargı kararları tespit edilmektedir. Bazı kararlarda yabancı dilde düzenlenen sözleşmenin hükümsüz olduğu kabul edilmekte; aksi yöndeki kararlarda ise, bu duruma rağmen sözleşmeye dayalı olarak talepte bulunulabileceği kabul edilmektedir. Ayrıca, bazı kararlarda “taraflardan birinin yabancı tabiiyetinde olması” veya “tarafların basiretli davranma yükümü taşıyan tacirler olması” gibi nedenlere dayalı olarak 805 sayılı Kanun’un uygulanmayacağına karar verdiği; fakat bu kararların Yargıtay tarafından bozulduğu görülmektedir. Çalışmanın ilk kısmında, 805 sayılı Kanun’un ve yabancı dildeki sözleşmelere bağlanan hukuki sonuçların açıklanması amaçlanmaktadır. İkinci kısımda, konuya ilişkin yargı kararları incelenecek ve son kısımda ise, düzenlemenin hukuk uygulamasındaki etkileri değerlendirilecektir.
Overview of antibacterial drug sales for 9 months of 2020
Authors:   DSM Group, Nechaeva Yuliya
Published: December 2020

Broad-spectrum antibiotics are used to treat various infectious diseases affecting the digestive tract, the respiratory and genitourinary systems. This group is one of the most numerous among medicinal products. There are currently more than 100 different active substances on the market that are classified as antibiotics. Considering the drug forms and dosages, the number of drugs exceeds 1,700 names.
Innovative medicines on the Russian pharmaceutical market:key players and main directions of development
Authors:   National Research University Higher School of Economics, Moscow, Russia, Chaplenko A.A. , Vlasov V.V. ,   National Research University Higher School of Economics, Moscow, Russia, Gildeeva G.N. ,   Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
Published: December 2020

In this paper, it was carried out a comprehensive study of the positions of innovative drugs in the Russian pharmaceutical market. Authors identified key barriers for developers of original drugs to receive marketing authorization in Russia. They analyzed share of drugs with new active ingredients in the total number of authorized drugs over 10 years, as well as the role of domestic developers. The leading role of transnational pharmaceutical corporations in the introduction of original drugs to the Russian market have been shown. In accordance with the presented data, brief recommendations have been given for improving the regulatory framework in the field of the development and marketing authorization of innovative drugs.
Use of Paper Spray Mass Spectrometry for Determining the Chemical Profile of Green Cavendish Banana (Musa AAA) Peel and Pulp Flours and Evaluation of Its Functional Potential
Authors: e Loyola Anna Cláudia , Silva Viviane , Silva Mauro , Rodrigues Camila , dos Santos Amanda , Melo Júlio , Augusti Rodinei , Fante Camila
Published: December 2020

Green Cavendish banana peel and pulp flours were obtained by three drying methods: oven dryer at 70 °C; air fryer at 180 °C and domestic oven at 180 °C, being the latter two new possibilities. Bioactive constituents using paper spray ionization mass spectrometry (PS-MS), phenolic identification and quantification by ultra-performance liquid chromatography with UV-Visible detection (UPLC/UV-Vis) and antioxidant capacity were evaluated. Phenolic acids showed distinct thermal stability between the treatments. Gallic acid was the predominant compound, ranging from (29.56 to 1211.74 mg 100 g−1) and had higher concentration than that found in other bananas described in literature. Green Cavendish banana flour is an advantageous source of bioactive compounds and antioxidant capacity, especially its peel. 26 compounds were identified by PS-MS: phenolics,organic acids, sugars, amino acid, phytosterol, iridoid and coumarin derivatives. Green Cavendish banana flour has great functional potential, and the air fryer can be a promising alternative for drying.
Unsteady aerodynamic identification based on recurrent neural networks
Authors: Zhang Bo , Han Jinglong , Zhang Tuanyuan , Ma Ruiqun
Published: December 2020

The dynamic stall at high angle of attack is an important aerodynamic problem faced by aircraft, and it has always been a hotspot of aerodynamic research. The traditional reduced order model (ROM) methods needs to establish an accurate model, and has a high demand for experience. In this paper, a novel nonlinear aerodynamic identification method based on recurrent neural networks (RNNs) is proposed. The computational fluid dynamics (CFD) method is used to calculate the unsteady aerodynamic parameters of the NACA0012 airfoil. A group of sinusoidal chirp signals with variable amplitude and frequency are adopted as the excitation signals, and the obtained data are used to train the recurrent neural networks, and the ROM of the nonlinear aerodynamic model of high angle of attack dynamic stall is obtained. Finally, the aerodynamic parameters of a group of composite sinusoidal motion signals different from the training signals are predicted by the trained neural networks model and compared with the CFD results.
La transformación histórica del paisaje de montaña en la vertiente atlántica del País Vasco: el caso de Aiako Harria (Oiartzun, Gipuzkoa)
Authors: Narbarte Hernandez Josu , Del Amo Jiménez Eneko
Published: December 2020

Los paisajes de montaña son el reflejo de las interacciones entre los grupos sociales y su medio ambiente, que se materializan en el espacio mediante la activación de los recursos por medio de diversas prácticas sociales. Este trabajo propone el desarrollo de una metodología de prospección basada en el análisis combinado de las coberturas terrestres y de los artefactos presentes en el paisaje, con el fin de reconstruir la historia social, económica y ecológica que subyace a la configuración actual del paisaje de montaña de Aiako Harria (Oiartzun, Gipuzkoa). Ante la aparente ilegibilidad de unos espacios a menudo observados desde un prisma puramente naturalístico, los resultados alcanzados ponen de relieve la densidad histórica de unos paisajes que actualmente se encuentran, en contraste, sujetos a un fuerte proceso de marginalización.
Agonism of Histaminergic-H1 Receptors in Ischemic Postconditioning During Cerebral Ischemia-Reperfusion Injury is Protective
Authors: Singh Prabhat , Sharma Bhupesh
Published: December 2020

Background:

Stroke is associated with cerebral ischemia/reperfusion (I/R) injury. Ischemic
postconditioning (IPoC) reduces cerebral ischemic injury in rats and offers neuroprotection.
The central histaminergic pathway possesses a crucial role in the pathogenesis of cerebral I/R,
but its neuroprotective role in IPoC is still unidentified.

Objective:

This research explored the role of the histaminergic in IPoC during cerebral I/R injury
in the rat.

Methods:

Global cerebral ischemia/reperfusion (GCI/R) injury in Wistar albino rats was induced
by occluding the bilateral carotid arteries for 10 minutes, followed by reperfusion. IPoC was provided
by giving three episodes of I/R post GCI (10 min), after which of reperfusion was permitted. Inclined-
beam-walk, hanging-wire, lateral-push, and rota-rod tests were employed to assess motor
functions, and Morris water maze (MWM) was used to assess spatial learning as well as memory
in animals. Cerebral oxidative markers (thiobarbituric acid reactive species-TBARS, reduced glutathione-
GSH), inflammatory markers (myeloperoxidase-MPO), acetylcholinesterase activity-
AChE, infarct size, and histopathological changes were also assessed. L-histidine and chlorpheniramine
were used as histaminergic agonists and antagonists.

Results:

I/R animals showed a reduction in memory and motor function, and an increase in cerebral
oxidative stress, inflammation, AChE activity, infarct size and histopathological changes. Episodes
of IPoC post-ischemia attenuated the deleterious effects of I/R injury. Pretreatment (30 min
before cerebral ischemia) with L-histidine mimicked the neuroprotective effects of IPoC. However,
neuroprotection produced by IPoC was abolished by pretreatment with chlorpheniramine (histaminergic-
H1 receptor antagonist).

Conclusion:

IPoC may provide neuroprotection against cerebral I/R induced brain injury by modulating
the histaminergic-H1-receptor pathway.
Impact of Endothelial NOS VNTR Variant on Susceptibility to Diabetic Neuropathy and Type 2 Diabetes Mellitus
Authors: Yigit Serbulent , Nursal Ayse Feyda , Uzun Suheyla , Rustemoglu Husniye , Dashatan Payam Amiri , Soylu Huseyin , Atmaca Aysegul , Rustemoglu Aydin , Kuruca Nilufer , Karakus Nevin
Published: December 2020

Purpose::

The aim of this study was to evaluate whether the VNTR intron 4b/4a variant
in the eNOS gene is associated with type 2 diabetes mellitus (T2DM) and DPN.

Methods::

A total of 598 subjects were enrolled in the study. eNOS VNTR 4b/4a variant was genotyped
by polymerase chain reaction (PCR) method.

Results::

eNOS VNTR intron 4b/4b genotype and b allele increased in patients with both DPN and
T2DM compared healthy controls (p=0.0005, OR:1.94, p= 0.000002, OR:4.10, respectively).
4a/4b genotype was more prevalent in controls than in DPN and T2DM patients (p=0.00008,
OR:0.46; p=0.000004, OR:0.24, respectively). eNOS VNTR b allele was more common in DPN patients
and T2DM patients compared with controls (p=0.007, p=0.00002, respectively).

Conclusion::

The eNOS VNTR “4b/4b” homozygous genotype and hence “4b”allele as a genetic
risk factor for T2DM and DPN, which may serve as a useful marker of increased susceptibility to
the risk of these disorders.
Tuberculosis: An Update on Pathophysiology, Molecular Mechanisms of Drug Resistance, Newer Anti-TB Drugs, Treatment Regimens and Host- Directed Therapies
Authors: Borah Pobitra , Deb Pran K. , Venugopala Katharigatta N. , Al-Shar’i Nizar A. , Singh Vinayak , Deka Satyendra , Srivastava Amavya , Tiwari Vinod , Mailavaram Raghu P.
Published: December 2020

Human tuberculosis (TB) is primarily caused by Mycobacterium tuberculosis (Mtb) that
inhabits inside and amidst immune cells of the host with adapted physiology to regulate
interdependent cellular functions with intact pathogenic potential. The complexity of this disease is
attributed to various factors such as the reactivation of latent TB form after prolonged persistence,
disease progression specifically in immunocompromised patients, advent of multi- and extensivelydrug
resistant (MDR and XDR) Mtb strains, adverse effects of tailor-made regimens, and drug-drug
interactions among anti-TB drugs and anti-HIV therapies. Thus, there is a compelling demand for
newer anti-TB drugs or regimens to overcome these obstacles. Considerable multifaceted
transformations in the current TB methodologies and molecular interventions underpinning hostpathogen
interactions and drug resistance mechanisms may assist to overcome the emerging drug
resistance. Evidently, recent scientific and clinical advances have revolutionised the diagnosis,
prevention, and treatment of all forms of the disease. This review sheds light on the current
understanding of the pathogenesis of TB disease, molecular mechanisms of drug-resistance,
progress on the development of novel or repurposed anti-TB drugs and regimens, host-directed
therapies, with particular emphasis on underlying knowledge gaps and prospective for futuristic TB
control programs.
Design of Inhibitory Peptides of the Interaction between the RBD Domain of the S1 Protein of SARS-CoV-2 and the Angiotensin-Converting Enzyme 2 (ACE2) Receptor
Authors: Rodríguez-Salazar Carlos Andrés , Recalde-Reyes Delia Piedad , Castaño-Osorio Jhon Carlos
Published: December 2020

Background:

The recent outbreak caused by SARS-CoV-2, known as COVID-19, has
been cataloged as a global catastrophe due to the growing number of infected cases and deaths since
November 2019; this infectious, contagious disease, to date, does not have a vaccine or specific
treatment available, which is why the number of cases continues to increase. SARS-CoV-2 infects
humans as a result of the interaction between the receptor-binding domain of the viral spike protein
and the receptor of the angiotensin-converting enzyme-2 (rACE2), located predominantly in the
alveolar cells.

Objective:

This study aims to identify inhibitory peptides of the protein-protein interaction between
the receptor-binding-domain of the spike protein of SARS-CoV-2 and the angiotensin-converting
enzyme-2 receptor through computational tools.

Methods:

Through the Research Collaboratory for Structural Bioinformatics protein database, crystals
were selected and interaction models were carried out between the viral protein and the ACE2;
thereafter, the study designed inhibitory peptides of the interaction through the Rosetta web server,
validated their interaction through ClusPro and, finally, determined the theoretical physicochemical
and cytotoxic properties.

Results:

A protein complex was generated and modeled through ClusPro; the balanced model was
selected with the lowest binding energy. From the protein interactions of each of the crystals and
from the model, eight peptides of 20 residues were obtained. The theoretical evaluation showed
non-toxic peptides, six soluble in water, and two insoluble.

Conclusion:

We found eight peptides interacted with the receptor-binding-domain of the Spike Protein of SARS-CoV-2,
which could avoid contact with the cell receptor and generate interference in the infection process.
Molecular Docking, DFT Studies and ADMET Simulations for Evaluating Already Approved FDA Drugs as Inhibitors for SARS-Cov-2 RNADependent Polymerase
Authors: Vlasiou Manos C. , Ioannou Kyriakos I. , Pafiti Kyriaki S.
Published: December 2020

Background:

Remdesivir, a drug in use for Ebola it is already tested in clinical trials
phase III.

Objective:

To evaluate any other possible related structures with similar properties that could be
used in clinical trials for COVID-19.

Methods:

Molecular docking studies, DFT studies, ADMET studies

Result:

Saquinavir is a chemical structure with similar and even a better chemical activity that drugs that entered clinical
trials for Covid-19

Conclusion:

Saquinavir should be entered the clinical trials for the treatment of the COVID-19
disease, as it has shown excellent binding affinities to SARS Cov-2 RNA depended polymerase and
forms stable complexes with the protein and could possible inhibited its action.
A Combined Approach of Pharmacophore Modeling, QSAR Study, Molecular Docking and In silico ADME/Tox Prediction of 4-Arylthio & 4-Aryloxy-3- Iodopyridine-2(1H)-one Analogs to Identify Potential Reverse Transcriptase Inhibitor: Anti-HIV Agents
Authors: Panigrahi Debadash , Mishra Amiyakanta , Sahu Susanta Kumar , Azam Mohd. Afzal , Vyshaag C.M.
Published: December 2020

Background:

Reverse transcriptase is an important therapeutic target to treat AIDS caused by the Human
Immunodeficiency Virus (HIV). Despite many effective anti-HIV drugs, reverse transcriptase (RT) inhibitors remain the
cornerstone of the drug regimen to treat AIDS. In the present work, we have expedited the use of different computational
modules and presented an easy, cost-effective and high throughput screening method to identify potential reverse
transcriptase inhibitors.

Methods:

A congeneric series of 4-Arylthio & 4-Aryloxy-3- Iodopyridine-2(1H)-one analogs having anti-HIV activity were
subjected to structure-based 2D, 3D QSAR, Pharmacophore Modeling, and Molecular Docking to elucidate the structural
properties required for the design of potent HIV-RT inhibitors. Prediction of preliminary Pharmacokinetic and the Drug
Likeliness profile was performed for these compounds by in silico ADME study.

Results:

The 2D and 3D- QSAR models were developed by correlating two and three-dimensional
descriptors with activity (pIC50) by sphere exclusion method and k-nearest neighbor molecular field
analysis approach, respectively. The significant 2D- QSAR model developed by Partial Least Square
is associated with the Sphere Exclusion method (PLS-SE), having r2 and q2 values 0.9509 and 0.8038,
respectively. The 3D-QSAR model by Step Wise variable selection method (SW-kNN MFA) is more
significant, which has a cross-validated squared correlation coefficient q2= 0.8509 and a non-crossvalidated
correlation coefficient pred_r2= 0.8102. The pharmacophore hypothesis was developed,
which comprised 5 features includes 3 aliphatic regions (Ala), 1 H-bond donor (HDr) and 1 H-bond
acceptor (HAc). Docking studies of the selected inhibitors with the active site of reverse transcriptase
enzyme showed hydrogen bond and π - π interaction with LYS-101, LYS-103, TYR- 181, TYR-188
and TRP-229 residues present at the active site. All the candidates with good bioavailability and
ADMET drug likeliness properties.

Conclusion:

The results of the present work provide more useful information and important structural insights for the
discovery, design of novel and potent reverse transcriptase inhibitors with high therapeutic windows in the future.
Dexamethasone Reduces Cell Adhesion and Migration of T47D Breast Cancer
Cell Line
Authors: Mohammadi Leila , Mosayyebi Bashir , Imani Mahsa , Rahmati Mohammad
Published: December 2020

Background:

Aberrant expression of cell adhesion molecules and matrix metalloproteinase (MMPs) plays a pivotal role in
tumor biological processes including progression and metastasis of cancer cells. Targeting these processes and detailed understanding of
their underlying molecular mechanism is an essential step in cancer treatment. Dexamethasone (Dex) is a type of synthetic corticosteroid
hormone used as adjuvant therapy in combination with current cancer treatments such as chemotherapy in order to alleviate its side
effects like acute nausea and vomiting. Recent evidences have suggested that Dex may have antitumor characteristics.

Objective:

Dex affects the migration and adhesion of T47D breast cancer cells as well as cell adhesion molecules e.g., cadherin and
integrin, and MMPs by regulating the expression levels of associated genes.

Methods:

In this study, we evaluated the cytotoxicity of Dex on the T47D breast cancer cell line through MTT assay. Cell adhesion assay
and wound healing assay were performed to determine the impact of Dex on cell adhesion and cell migration, respectively. Moreover,
real-time PCR was used to measure the levels of α and β integrin, E-cadherin, N-cadherin, MMP-2, and MMP-9.

Results:

Dex decreased the viability of T47D cells in a time and dose-dependent manner. Cell adhesion and migration of T47D cells were
reduced upon Dex treatment. The expression of α and β integrin, E-cadherin, N-cadherin, MMP-2, and MMP-9 were altered in response
to the Dex treatment.

Conclusion:

Our findings demonstrated that Dex may have a role in the prevention of metastasis in this cell line.
Study to Know the Impact of Ayurvedic Lifestyle on Dark Circles Around
Eyes
Authors: P Ankita , Harti Shivakumar , Rao Mangalagowri
Published: December 2020

Background::

The Dark circles under the eyes, is very common and frustrating cosmetic grievance in both male and female especially among the stress prone population. Due to various reasons, skin becomes very thin and dry leading to the visible appearance of veins. This makes skin appear very dark. Possible causes include excessive pigmenta-tion, thin and luminous lower eyelid, lack of sleep, excessive fatigue, heredity, allergic disorders and aging. Dark circles comes under the broad umbrella of features of aggravation of Vata like blackish discoloration (Karshnya), Dark coloration (Shyavata) which can also be categorized under disease predominant in Vata (Vata Nanatmaja Vikara). In spite of its prevalence and cosmetic importance, there are very few reported works regarding dark circles.

Objectives::

This study was an attempt to find the most probable and commonest factor that influences dark circles so that modifications can be made in lifestyle as mentioned in Ayurveda in the form of daily regimen (Dinacharya) and Night regimen (Ratricharya).

Methods::

30 subjects (20-40 years) each with or without dark circles were registered and Case Control survey was con-ducted using a standard questionnaire. A questionnaire was prepared comprising of different processes of daily regimen (Dinacharya vidhis) as per ideal Ayurveda lifestyle. The perceived stress scale that may influence the development of dark circles was also included in the study. The data collected were computed in the excel sheet .The data was analyzed by applying odd’s ratio and Chi square test.

Results::

A positive relationship between intake of ghee and milk and absence of dark circles was observed and odd’s ratio calculated as 1.5 and 3.54 respectively. The subjects practicing Yoga were found less affected by dark circles odd’s ratio was calculated 3.7. Stress was moderately high among the subjects having dark circles.

Conclusion::

The present study shows that individuals following Ayurvedic lifestyle in the form of processes of daily reg-imen (Dinacharya vidhis) like head and feet massage with oil, Yogic practices, taking milk and ghee in diet regularly and taking adequate sleep, are less prone to loss of lusture in the form of dark circles around the eyes.
Caffeic Acid Phenethyl Ester (CAPE), Active Phenolic Compound of
Propolis Attenuates Endothelin, Prostaglandin F2α and U46619 Elicited
Contractions of Isolated Human Umbilical Artery
Authors: Duman Ipek , Soner Burak Cem , Inan Salim Yalcin , Sahin Ayse Saide
Published: December 2020

Background:

Propolis is a product of honeybees that contains a variety of different compounds, including caffeic acid phenethyl ester (CAPE). Propolis and its bioactive compounds are widely used in folk medicine and as a dietary
supplement. Previously it has been shown that CAPE has antioxidant, anti-inflammatory, antimicrobial, antiviral, immunomodulatory, and anticancer activity.

Objective:

This in vitro study was designed to investigate the vasoactive effects of CAPE on quiescent and precontracted
human umbilical arteries.

Methods:

Umbilical artery strips were suspended in aerated organ baths containing a buffer solution. The strips were randomly allocated to study groups (n=8). Via a transducer and computer, changes in isometric tension were recorded. The
effects of cumulative CAPE (10-8-10-4M) on basal tone of the artery, and in different groups of strips, the vasodilatory effect of cumulative CAPE on the constriction elicited by endothelin (ET-1), prostaglandin F2α (PGF2α) and U46619, and
the effect of incubation with NO synthase inhibitor L-NAME, were recorded.

Conclusion:

CAPE elicits concentration-dependent relaxation on precontracted human umbilical artery strips depending
on the constrictor agent. NO plays significant role in CAPE’s vasorelaxant effect.
The water industry and decarbonisation of cities: A review
Authors: Fisher Peter M.J. , Smith David
Published: December 2020

:

The urban water industry is a very energy intensive industry. Higher water quality standards are driving a level
of energy growth that is threatening to move it to the top rank. Climate change is further exacerbating this situation:
Growing aridity is variously imposing an enhanced carbon burden through water recycling, trans-regional pipelines and
desalination plants. Natural disasters too can often affect water quality requiring energy hungry mitigations.
There’s clear evidence that a failure to appropriately weight energy considerations in water infrastructure is commonplace
and that this is an unsustainable position for the industry and is prejudicial to working towards zero carbon cities. Real
time tracking of CO2e emissions is an important starting point in raising operator consciousness and introducing rivalry
between utilities in attaining abatement. So too is reaching out to the resource and manufacturing sectors to form strategic
alliances as well as seeking to enter into closer relationships with the energy sector.
Review on Diagnostic Methods for SARS-CoV-2
Authors: Chauriya Chandrashekhar , Sahu Mahesh , Singh Anuj Kumar , Verma Amita
Published: December 2020

Background::

In December 2019, a large number of patients with a novel coronavirus
were identified in Wuhan, China. The novel coronavirus (COVID-19) is highly contagious and increasing
the rate of mortality day by day. The World Health Organization declared COVID-19 as a
worldwide pandemic on March 11, 2020. Early diagnosis of SARS-CoV-2 can restrict the
COVID-19 pandemic.

Objective::

We aim to study the currently available diagnostic methods for COVID-19.

Methods::

World Health Organisation portal, Centre for Disease Control and Prevention portal, Indian
Council of Medical Research portal, Chinese Centre for Disease Control and Prevention portal,
Science Direct, Google Scholar, Research Gate, etc. were searched for obtaining data.

Results::

Rapid diagnosis and prompt treatment can reduce the number of prospective cases. The diagnostic
strategy encompasses the screening of the virus with nucleic acid amplification test
(NAAT) such as real-time reverse-transcription polymerase chain reaction (RT-PCR) assays. Serological
testing is a diagnostic procedure used for identifying the presence of immune responses. Radiological
findings in individuals with COVID-19 are characterised by multiple areas of consolidation
in the chest. Rapid antigen tests are in-vitro diagnostics that have been designed to give results
within 10-20 min.

Conclusion::

Rapid, simple, and safe diagnosis of COVID-19 has a great impact on deciding clinical
and epidemiological factors. RT-PCR results often require 5 to 6 hours. Diagnosis by serological
testing is not suitable but important epidemiologically. At present, the best radiological strategy
remains undefined. Rapid antigen tests have limitations on sensitivity.
'Het is vol wondren om ons heen'. Over wonderen, wetenschap en wereldbeeld
Authors: Peels R.
Published: December 2020

How do miracles in the Christian tradition, such as the resurrection of Christ, relate to the methods, explanations, and ways of thinking that science and academic scholarship more generally pursue? Do the two conflict? What is the problem? This article explores seven possible obstacles and argues that none of them constitutes a serious challenge to believing both in miracles as specific acts of God and the value and validity of science. Rather, miracles constitute a challenge to an entirely naturalistic worldview.
Justification for Integrated Care of Dementia and Presbycusis: Focused on National Dementia Policy
Authors: Park Sihun , Han Woojae , Park Kyoung-Ho
Published: December 2020

Dementia management has become one of essential factors in the national policy globally in terms of the elderly health care service. In the brief communication, we compared various national reports from other countries to see whether current care service for the dementia had integrative approach for the patients with hearing loss in Korea. We also discussed a need of systematic hearing care for the elderly with dementia who was also a suspected case of aged-related hearing loss because many studies had confirmed that untreated hearing loss has a negative effect on dementia and vice versa. After analyzing the national policy from several countries, we found that the systems had been well established to screen dementia patients by using various clinical tests in UK, Canada, and Japan who provided appropriate services by classifying types of the dementia. Remarkably, the hearing test was included as the testing protocol for the dementia in Canada and the experts such as speech pathologists and music therapists had worked in a non-pharmacotherapy program for the elderly with dementia in France. Unfortunately, the dementia policy of Korea needs to be refined when considering the hearing care/management in that the integrated management of hearing and dementia are important. In addition, the clinicians who work for the dementia care home need to know audiological knowledge. Since the auditory training and rehabilitation for the elderly can reduce increased rate of cognitive decline, we strongly recommend that auditory training should be a part of the cognitive rehabilitation programs in the dementia care home.
The Preliminary Study for Development of Phoneme Perception Test Tool in the School-Aged Children
Authors: Shin Eun-Yeong , Lee HyoIn , Cho Soo Jin
Published: December 2020

Purpose: The purpose of this study is to develop a test list for school-aged children that can evaluate consonant perception ability and verify the validity and difficulty.Methods: The test list consisted of 127 initial and 94 final consonant test items with a meaningful one-syllable words and was developed in two types for each difficulty level. To verify the validity of the developed phoneme perception test tool, twenty children with normal hearing were tested for the validity of the results and the contents were verified by experts in various fields.Results: As a result of comparing the rate of correct response according to the type of test item (initial vs. final consonant) and difficulty (easy vs. difficult item), the initial and easy responses were higher than the final and hard item, respectively, so the difficulty level of the test list was appropriate. In addition, there was no statistical difference in the rate of correct answers according to the test speakers, and the content validity analysis for experts verified that the developed test list was appropriate as a phoneme perception test tool for school-age children.Conclusion: The initial and final consonant test items developed through this study consisted of one target word and three examples which are a pair of minimum confrontation with the target word and are heteromorphic test lists consisting of easy and hard types according to the difficulty of the example. It could also be useful for not only the evaluation of the consonant perception ability but also rehabilitation.
Исследование массотранспортных потерь структурно-модифицированных электродов воздушно-водородных топливных элементов методом вольт-амперной характеристики
Authors: Глебова Н.В. , Краснова А.О. , Нечитайлов А.А. , Томасов А.А. , Зеленина Н.К.
Published: December 2020

The article discusses platinum-carbon electrodes with mixed conductivity as part of membrane-electrode assemblies of fuel cells containing structural-modifying additives with structural elements of various types: carbon nanotubes with elongated structural elements and graphene-like materials with almost two-dimensional planes. Based on the data on the limiting current density obtained in potentiodynamic and potentiostatic modes, the mass transport losses of molecular oxygen transfer in these electrodes are investigated. Using different measurement conditions, the baric dependences of the current density were constructed, the limiting factors and mechanisms of oxygen transfer in the studied structures and the role of the introduced modifiers were clarified.
Параметры фазовой синхронизации в электроэнцефалографических паттернах как маркеры когнитивных нарушений
Authors: Дик O.E. , Глазов A.Л.
Published: December 2020

The differences in phase synchronization between intermittent photostimulation and bioelectrical activity of the brain in the form of electroencephalographic patterns in two groups of people with chronically elevated blood pressure, with and without moderate manifestations of cognitive functions are investigated. It was found that the phase synchronization parameters calculated on the basis of the synchrosqueezed wavelet transform of the electroencephalographic patterns and photostimulus can be markers of mild cognitive impairment.
Memoria, Patrimonio, Consumo y Olvido
Authors: Pérgolis-Valsecchi Juan Carlos , Quijano-Gómez Estefanía
Published: December 2020

La plaza-circo-teatro La Serrezuela, en Cartagena, un lugar para el disfrute colectivo, fue reemplazada por un centro comercial, con un simulacro de la vieja Plaza. El cambio del ritual comunitario del espectáculo, por el entretenimiento individualista del consumo, destruyó la pasión en todas las actividades. Varios edificios en Medellín y Bogotá fueron transformados y demolidos para dar paso a actividades basadas en el individualismo del esparcimiento como soporte del consumo. Edificios patrimoniales de gran presencia en la memoria urbana, representantes del espíritu del tiempo en cada ciudad, muestran que hay momentos de la historia en los que la sociedad escoge el olvido.
Status and Recommendations of Technological and Data-Driven Innovations in Cancer Care: Focus Group Study
Authors: Kondylakis Haridimos , Axenie Cristian , (Kiran) Bastola Dhundy , Katehakis Dimitrios G , Kouroubali Angelina , Kurz Daria , Larburu Nekane , Macía Iván , Maguire Roma , Maramis Christos , Marias Kostas , Morrow Philip , Muro Naiara , Núñez-Benjumea Francisco José , Rampun Andrik , Rivera-Romero Octavio , Scotney Bryan , Signorelli Gabriel , Wang Hui , Tsiknakis Manolis , Zwiggelaar Reyer
Published: December 2020

Background

The status of the data-driven management of cancer care as well as the challenges, opportunities, and recommendations aimed at accelerating the rate of progress in this field are topics of great interest. Two international workshops, one conducted in June 2019 in Cordoba, Spain, and one in October 2019 in Athens, Greece, were organized by four Horizon 2020 (H2020) European Union (EU)–funded projects: BOUNCE, CATCH ITN, DESIREE, and MyPal. The issues covered included patient engagement, knowledge and data-driven decision support systems, patient journey, rehabilitation, personalized diagnosis, trust, assessment of guidelines, and interoperability of information and communication technology (ICT) platforms. A series of recommendations was provided as the complex landscape of data-driven technical innovation in cancer care was portrayed.

Objective

This study aims to provide information on the current state of the art of technology and data-driven innovations for the management of cancer care through the work of four EU H2020–funded projects.

Methods

Two international workshops on ICT in the management of cancer care were held, and several topics were identified through discussion among the participants. A focus group was formulated after the second workshop, in which the status of technological and data-driven cancer management as well as the challenges, opportunities, and recommendations in this area were collected and analyzed.

Results

Technical and data-driven innovations provide promising tools for the management of cancer care. However, several challenges must be successfully addressed, such as patient engagement, interoperability of ICT-based systems, knowledge management, and trust. This paper analyzes these challenges, which can be opportunities for further research and practical implementation and can provide practical recommendations for future work.

Conclusions

Technology and data-driven innovations are becoming an integral part of cancer care management. In this process, specific challenges need to be addressed, such as increasing trust and engaging the whole stakeholder ecosystem, to fully benefit from these innovations.
Dental Treatments During the COVID-19 Pandemic in Three Hospitals in Jordan: Retrospective Study
Authors: Obeidat Lina , Masarwa Nader , AlWarawreh Amjad , El-Naji Waddah
Published: December 2020

Background

Cases of COVID-19 first emerged in December 2019. Since then, the virus has spread rapidly worldwide, with daily increases in the numbers of infections and deaths. COVID-19 spreads via airborne transmission, which renders dental treatment a potential source of virus transmission. Dental treatments require the use of handpieces, ultrasonic devices, or air–water syringes, which generate considerable amounts of aerosols. Jordan, being one of the affected countries, instituted preventive lockdown measures on March 17, 2020. Emergency dental treatments were only allowed in dental clinics of the Royal Medical Services of Jordan Armed Forces and Ministry of Health, and were prohibited in other sectors such as private clinics and universities.

Objective

The aim of this study is to investigate the dental treatments performed in three military hospitals during the 44-day lockdown period in Jordan. The investigation explores the impact of COVID-19 on the number of patients and types of performed dental treatments.

Methods

Data such as number of patients, patients’ age and gender, and performed dental treatments were collected retrospectively from the hospital records and were analyzed.

Results

Our results showed a 90% (17,591 to 1689) decrease in patient visits during the lockdown period compared to regular days. The total number of treatments (n=1689) during the lockdown period varied between endodontic cases (n=877, 51.9%), extraction and other surgical cases (n=374, 22.1%), restorative cases (n=142, 8.4%), orthodontic treatments (n=4, 0.2%), and other procedures (n=292, 17.3%). The differences in gender and age group among all clinics were statistically significant (P<.001 and P=.02, respectively).

Conclusions

The COVID-19 pandemic had a significant effect on the number of patients seeking dental treatments. It also affected the types of treatments performed. Endodontic treatment accounted for almost 50% of patient load during the lockdown compared to approximately 20% during regular days.
Factors Influencing Patients’ Initial Decisions Regarding Telepsychiatry Participation During the COVID-19 Pandemic: Telephone-Based Survey
Authors: Severe Jennifer , Tang Ruiqi , Horbatch Faith , Onishchenko Regina , Naini Vidisha , Blazek Mary Carol
Published: December 2020

Background

Telepsychiatry enables patients to establish or maintain psychiatric care during the COVID-19 pandemic. Little is known about the factors influencing patients’ initial decisions to participate in telepsychiatry in the midst of a public health crisis.

Objective

This paper seeks to examine factors influencing patients’ initial decisions to accept or decline telepsychiatry immediately after the stay-at-home order in Michigan, their initial choice of virtual care modality (video or telephone), and their anticipated participation in telepsychiatry once clinics reopen for in-person visits.

Methods

Between June and August 2020, we conducted a telephone-based survey using a questionnaire comprising 14 quantitative and two qualitative items as part of a quality improvement initiative. We targeted patients who had an in-person appointment date that fell in the first few weeks following the Michigan governor’s stay-at-home order, necessitating conversion to virtual visits or deferment of in-person care. We used descriptive statistics to report individual survey responses and assess the association between chosen visit type and patient characteristics and future participation in telepsychiatry using multivariable logistic regression.

Results

A total of 244 patients whose original in-person appointments were scheduled within the first 3 weeks of the stay-at-home order in Michigan completed the telephone survey. The majority of the 244 respondents (n=202, 82.8%) initially chose to receive psychiatric care through video visits, while 13.5% (n=33) chose telephone visits and 1.2% (n=3) decided to postpone care until in-person visit availability. Patient age correlated with chosen visit type (P<.001; 95% CI 0.02-0.06). Patients aged ≥44 years were more likely than patients aged 0-44 years to opt for telephone visits (relative risk reduction [RRR] 1.2; 95% CI 1.06-1.35). Patient sex (P=.99), race (P=.06), type of insurance (P=.08), and number of previous visits to the clinic (P=.63) were not statistically relevant. Half of the respondents (132/244, 54.1%) stated theywere likely to continue with telepsychiatry even after in-person visits were made available. Telephone visit users were less likely than video visit users to anticipate future participation in telepsychiatry (RRR 1.08; 95% CI 0.97-1.2). Overall, virtual visits met or exceeded expectations for the majority of users.

Conclusions

In this cohort, patient age correlates with the choice of virtual visit type, with older adults more likely to choose telephone visits over video visits. Understanding challenges to patient-facing technologies can help advance health equity and guide best practices for engaging patients and families through telehealth.
REDCap Delivery of a Web-Based Intervention for Patients With Voice Disorders: Usability Study (Preprint)
Authors: Stambler Danielle Mollie , Feddema Erin , Riggins Olivia , Campeau Kari , Breuch Lee-Ann Kastman , Kessler Molly M , Misono Stephanie
Published: December 2020

BACKGROUND

Web-based health interventions are increasingly common and are promising for patients with voice disorders because web-based participation does not require voice use. To address needs such as Health Insurance Portability and Accountability Act compliance, unique user access, the ability to send automated reminders, and a limited development budget, we used the Research Electronic Data Capture (REDCap) data management platform to deliver a patient-facing psychological intervention designed for patients with voice disorders. This was a novel use of REDCap.

OBJECTIVE

We aimed to evaluate the usability of the intervention, with this intervention serving as a use case for REDCap-based patient-facing interventions.

METHODS

We used REDCap survey instruments to develop the web-based voice intervention modules, then conducted usability evaluations using (1) heuristic evaluations by 2 evaluators, and (2) formal usability testing with 7 participants, consisting of predetermined tasks, a think-aloud protocol, ease-of-use measurements, a product reaction card, and a debriefing interview.

RESULTS

Heuristic evaluations found strengths in visibility of system status and real-world match, and weaknesses in user control and help documentation. Based on this feedback, changes to the intervention were made before usability testing. Overall, usability testing participants found the intervention useful and easy to use, although testing revealed some concerns with design, content, and terminology. Some concerns were readily addressed, and others required adaptations within REDCap.

CONCLUSIONS

The REDCap version of a complex web-based patient-facing intervention performed well in heuristic evaluation and formal usability testing. REDCap can effectively be used for patient-facing intervention delivery, particularly if the limitations of the platform are anticipated and mitigated.
TRANNING KASIR DALAM RANGKA PENGEMBANGAN SKILL SISWA SMK DI BIDANG PERBANKAN DAN KEUANGAN
Authors: Rachmawati Diana Widhi
Published: December 2020

Metode kegiatan Pengabdian kepada Masyarakat dilakukan secara ceramah dan tanya jawab di Gedung Seminar UPTD BLPT Sumsel. Tema yang diangkat “Tranning Kasir Bagi Siswa – Siswi SMK Perbankan Aluminika Palembang Dalam Rangka Mengembangkan Skill Siswa SMK Di Bidang Perbankan dan Keuangan”. Narasumber pada kegiatan ini adalah Dosen Universitas PGRI Palembang dan BME Group Jakarta, yang saat itu sekaligus juga sebagai Section Head dan Customer Development Manager di PT Lottemart Grosir Palembang. Peserta yang menghadiri dalam kegiatan ini merupakan siswa dan guru SMK Perbankan Aluminika Palembang. Kegiatan tim PkM ini telah terlaksana dengan baik dan selesai sebagaimana waktu yang telah ditentukan. Setelah masing-masing pemateri memberikan  penjelasan, diberikan kesempatan untuk guru dan siswa mengajukan beberapa pertanyaan materi yang diberikan, Kesimpulan, Laporan pengabdian kepada masyarakat ini dilaksanakan dan diselesaikan melalui prosedur dengan sebenar-benarnya yang diharapkan dapat memberikan kontribusi dalam ilmu pengetahuan di siswa. dan guru tidak hanya itu juga, kegiatan PkM yang dilaksanakan pada tanggal 27 Oktober 2015  juga dapat meningkatkan dan membangkitkan rasa profesionalisme dosen Universitas PGRI Palembang dan BME Group Jakarta, sekaligus sebagai perwujudan keikutsertaan perusahaan PT Lottemart Grosir Palembang dalam mencerdaskan  bangsa, juga  meningkatkan pengetahuan serta pemahaman peserta didik khususnya guru dan siswa di lingkungan SMK Perbankan Aluminika Palembang. Saran, Harapannya kegiatan ini dapat terus dilaksanakan  secara  berkelanjutan guna memberikan pengetahuan  dan  memperdalam pengetahuan atau  pemahaman guru dan siswa tentang pengembangan skill siswa SMK di bidang perbankan dan keuangan. Kata Kunci : Tranning Kasir SMK Perbankan Aluminika Palembang