bluuebunny/crossref_metadata_2025 huggingface dataset:
Nitrogen Leaching Loss Estimation from Paddy Soil in the Taihu Lake Region of China by a Newly Developed Simple Model
Authors: Xie Wen-Ming , Xie Wen-Ming , Ma You , Li Shi-Jun , Sh Wei-Ming , Zhang Hai-Lin , Fang Fang , Meng Han , Wang Guo-Xiang , Zhang Li-Min
Published: December 2019

Nitrogen leaching as a direct pathway of N loss from agricultural land can negatively affect groundwater and surface water quality. However, a simple and efficient method for nitrogen leaching loss estimation is still inefficient. In this study, an exponential model was developed using the experimental data from a two-year field experiment conducted in the Taihu Lake region of China to simulate the N leaching from the paddy soil. The results showed the leached N was in the range of 5.66 to 8.45 kg N/ha during the whole rice season, which was accounted for 1.7%-2.1% of the applied N. A good agreement between the measured and model predicted results for N leaching loss was observed, suggesting the validity of the established model. The model was further validated with the data of other studies in other regions. The results demonstrated this model is able to simulate the N leaching loss accurately and can provide a beneficial tool for users to predict N leaching loss in paddy soil.
The relationship of vitamin D status with the development and course of diabetes mellitus type 1
Authors: Povaliaeva Alexandra A. , Pigarova Ekaterina A. , Dzeranova Larisa K. , Rozhinskaya Liudmila Ya.
Published: December 2019

Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease that develops as a result of a genetic predisposition and environmental factors. Literature data indicate that the suboptimal status of vitamin D can be considered as a risk factor for the development of T1DM, especially at some stages of life. Adequate vitamin D supplementation in childhood may provide a protective effect and reduce the risk of developing T1DM at a later age. Pathogenesis of T1DM predisposes to abnormalities in the metabolism of vitamin D, including the development of vitamin D deficiency. Moreover, the immunomodulating effect of calcitriol (induction of immune tolerance and T-cell anergy, impaired B-cell activity and antibodies production) suggests the therapeutic potential of vitamin D in autoimmune diseases, including T1DM. A number of studies have demonstrated the positive clinical effects of various vitamin D preparations with respect to maintaining residual -cell function, improving glycemia control in patients with T1DM. Determining the optimal doses of vitamin D for patients with T1DM may contribute to disease control and prevention of complications.
Educación y territorio: abordajes desde el Programa Integral Metropolitano de la Universidad de la República
Authors: Cano Menoni Agustín , Cavalli Dalla Rizza Valeria , Cassanello Carina Alejandra , Caggiani Gómez Juan
Published: December 2019

El siguiente artículo reflexiona sobre las características y potencialidades de abordar las políticas educativas y los procesos pedagógicos desde el territorio y un enfoque de diálogo de saberes, en el marco de un programa integral de la Universidad de la República (UdelaR) que articula las funciones universitarias de extensión, investigación y enseñanza. Para ello, presentaremos al Programa Integral Metropolitano (PIM) y tomaremos específicamente las líneas de trabajo que lleva adelante el Núcleo de intervención e investigación Educación y Territorio de dicho Programa. En ese sentido, se desarrollará el marco histórico, teórico y metodológico que define su quehacer, las especificidades del territorio de incidencia donde lleva adelante sus actividades y las líneas de investigación que el núcleo desarrolla en torno a temáticas y problemáticas educativas emergentes de los procesos de extensión y articulación con las instituciones educativas y organizaciones sociales de la zona.
Experiencias de trabajo con población migrante en Montevideo. Estrategias de intervención desde la extensión universitaria
Authors: Garibaldi Rivoir Cecilia , Gómez Caraballo Gonzalo
Published: December 2019

En el presente artículo se abordan los desafíos específicos que asume el trabajo de extensión universitaria con población migrante en la ciudad de Montevideo. Dando continuidad a un proceso de cinco años de trabajo en la temática desde la Licenciatura en Antropología, llevamos adelante un proyecto de extensión para trabajar con migrantes de habla no hispana en el período 2016–2017, en el que nos propusimos indagar y acompañar el vínculo entre la sociedad civil y la población migrante, así como comprender y fortalecer herramientas colectivas que la misma construye en la capital uruguaya como contexto de acogida. A partir de la experiencia de trabajo conjunta entre actores universitarios y la organización civil Idas y Vueltas, se generaron talleres de intercambio y diálogo sobre las demandas construidas con esta población. Tanto los resultados como las reflexiones en torno al proceso de desarrollo del proyecto son aspectos centrales a abordar en este artículo.
Tejiendo tramas entre arte, extensión universitaria y paisaje local en Palmar, Uruguay
Authors: Articardi Juan , Goñi Ana Laura , Sánchez Victoria
Published: December 2019

El presente artículo sistematiza la experiencia de un espacio de formación integral desarrollado desde un Taller de Proyectos de la Licenciatura en Diseño de Paisaje en el Centro Universitario Regional del Este, Universidad de la República, Uruguay. El espacio apunta a la integralidad de las funciones universitarias: extensión, enseñanza e investigación, como tríada articulada.La metáfora de la trama nos permite entrelazar experiencias que hemos ido tejiendo en este espacio en etapas sucesivas que parten de una primera trama localizada en el Parque de Esculturas en Palmar, donde se inicia la interacción entre escultores, docentes universitarios y estudiantes, para luego extender sus filamentos hacia una segunda trama en la Ruta de las Esculturas Palmar–Mercedes, en la cual se expande el mapa de actores incluyendo a gobernantes locales, funcionarios y vecinos, y finalmente, una tercera trama, que denominamos "en transformación", que representa el momento actual del trabajo del colectivo.
Extensão universitária participativa para a sustentabilidade: artesanato identitário da Associação Mães de Nazaré de Chapecó
Authors: De Borba Novakowski Graciela Alves , Casagrande Begnini Andréia , Bregolin Cerutti Bernardete
Published: December 2019

Este trabalho relata a experiência do projeto de pesquisa e extensão universitária coordenada pela Incubadora Tecnológica de Cooperativas Populares (ITCP) da Universidade Comunitária da Região de Chapecó (Unochapecó) junto à associação de artesanato Mães de Nazaré de Chapecó. Como procedimento metodológico, foi utilizada a pesquisa participante, onde pesquisados e pesquisadores puderam construir e desenvolver o projeto conjuntamente. Foi definido no decorrer do processo como objetivo orientar as artesãs para a produção de artesanato que identifique a região e estabeleça uma relação direta com os novos mercados, as tendências e demandas que podem ser exploradas de forma significativa – turismo, eventos, gastronomia, design e decoração, entre outras. Trata-se de um tema que envolve tramas, identidades e políticas na construção do território.Como resultado, ao término do projeto, a associação ampliou o número de participantes e inseriu em sua prática conceitos de autogestão que possibilitou o aumento da produção, a inclusão social e o reconhecimento do produto no mercado local.
Agenda Redes
Authors: Iucci Cecilia
Published: December 2019

En esta sección se informa sobre las agendas de trabajo que están llevando adelante la Unión Latinoamericana de Extensión Universitaria (ULEU); la Comisión Permanente de Extensión Universitaria de la Asociación de Universidades del Grupo Montevideo (AUGM) y de la Red Nacional de Extensión Universitaria de Argentina (REXUNI).
EVALUASI KESESUAIAN LAHAN DAN ARAHAN PENGENDALIAN PEMANFAATAN RUANG DI KECAMATAN MANDAU
Authors: Wahyudi Ade
Published: December 2019

Mandau Urban Area is a fast-growing economy which plays an important role as a center of trade and services as well as plantations, strategic industrial area on a national scale with oil and gas potential. Given these economic potentials, Mandau Urban Area undergoes significant physical development which causes high rate of land conversion and is being susceptible to manipulation of spatial utilization. As a result, spatial utilization in Mandau Urban Area is inconsistent with The Bengkalis Regency spatial plan. This research aims to evaluate the land suitability and the implementation of the instruments regarding spatial utilization monitoring. Also, it provides some recommendations concerning spatial utilization monitoring in order to ensure the orderly spatial utilization in Mandau Urban Area. In this study, development and evaluation methods are adopted. The result indicates that the instruments of spatial utilization monitoring in Mandau Urban Area has worked well. The percentage of land use, which is consistent with the spatial pattern defined in The Bengkalis Regency Spatial Plan, is approximately 79.9%. Moreover, the percentage of spatial pattern which has not been implemented yet reaches 8.3%; while the remaining percentage (3.3%) is inappropriate spatial pattern. Therefore, This study concludes some recommendations on spatial utilization monitoring.
KUALITAS HIDUP DAN PERTUMBUHAN EKONOMI, STUDI KASUS DKI JAKARTA DAN DAERAH PENYANGGANYA
Authors: Karim Malik Al , Utomo Galih Jati , Fauziah Bella
Published: December 2019

This study aims to analyze the phenomenon of urban sprawl development from aspects of value added, quality of life and economic growth to sub urban area of DKI Jakarta. The city are Bekasi City, Bekasi Regency, Depok City, Bogor City, Bogor Regency, Tangerang City, South Tangerang City, and Tangerang Regency. The research method was desk study with  variables population, typology of city, Human Development Index (HDI), Gross Regional Domestic Product (GRDP), education level, proportion of labor, access to Jakarta and distribution of settlements. The results of this research are (1) urban sprawl increases the population and the development of regions around the city including economic agglomeration to the sub urban area. It can be seen from the change of land use in each region become an area of settlement, commercial, industrial, or service and the development of new infrastructure and centers of economic growth.  (2) economic growth in the sub urban area have an increase in GDP per year. Based on this, there is no competitiveness between the DKI Jakarta sub urban areas developing not based on competition but complementary. (3) The city of South Tangerang is considered to have the best quality of life. This is seen from the highest value of South Tangerang City HDI compared to other regions.
Exploring the formaldehyde reactivity of tannins with different molecular weight distributions: bayberry tannins and larch tannins
Authors: Yang Tao , Dong Mengqi , Cui Juqing , Gan Lu , Han Shuguang
Published: December 2019

In recent years, tannin degradation has been used to obtain tannin materials with an optimal molecular weight distribution (MWD) for synthesizing tannin-formaldehyde (TF) resin with high performance, but the optimal MWD of tannins is still unknown. The excellent formaldehyde reactivity of tannins is the basis for the synthesis of high-performance TF resin. Based on the formaldehyde reactivity of tannins, bayberry tannins and larch tannins were used to explore the optimal MWD of tannins for TF resin synthesis. Progressive solvent precipitation (PSP) was used to obtain tannin fractions with different MWDs. The formaldehyde reactivity of tannins was determined using the modified Stiansy method combined with the standard curve method (GB/T 17657-2013). The bayberry tannin fraction [weight-average molecular weight (Mw) of acetylated tannin: 4115, mean degree of polymerization (mDP): 6.64] and the larch tannin fraction (Mw of acetylated tannin: 3906, mDP: 5.84) had the best formaldehyde reactivity. Furthermore, significant differences in the formaldehyde reactivity of condensed tannins (CTs) with different MWDs were observed. The obtained results can be used to purposefully degrade tannins to achieve an optimal MWD, which is beneficial for the production of TF adhesives with high performance.
Kinetics of oxide scale growth on a (Ti, Mo)5Si3 based oxidation resistant Mo-Ti-Si alloy at 900-1300∘C
Authors: Majumdar Sanjib , Singh Pankaj Kumar , Pandey Ajoy Kumar , Rao G.V.S. Nageswara
Published: December 2019

High-temperature oxidation behaviour of Mo-40Ti-30Si (at.%) alloy was investigated in the temperature regime of 900-1300∘C in air. Isothermal weight change data recorded up to 100 h of exposure revealed parabolic weight gain kinetics at all the tested temperatures. The protective oxide scale composed with SiO2 (silica) and TiO2 (titania) forming a duplex oxide microstructure consisting of TiO2 particles embedded in the continuous SiO2 matrix. The oxide scale showed parabolic growth kinetics, and the activation energies for the scale growth were found to be 72.2 kJ/mol in 900-1200∘C and 324.9 kJ/mol in 1200-1300∘C. The kinetics of the protective scale growth on the alloy surface was mainly controlled by the growth of the silica film and the inward diffusion of oxygen through the duplex oxide layer.
All-optical targeted drug delivery and real-time detection of a single cancer cell
Authors: Liu Xiaole , Yuan Jie , Wu Dong , Zou Xiaobin , Zheng Qing , Zhang Weina , Lei Hongxiang
Published: December 2019

Targeted drug delivery and real-time detection both play an important role for studying the specificity of a single cancer cell and the development of anticancer drugs. However, a method that simultaneously enables safe and efficient targeted drug delivery and noninvasive, free-label cell detection is highly desirable but challenging. Here, we report an all-optical method that combines fiber optical tweezers with laser Raman microspectroscopy, which can achieve targeted drug delivery to a single cancer cell using optical manipulation in vitro quickly and accurately by a tapered fiber probe, and simultaneously record the corresponding active characteristics of the targeted cancer cell under the contact of delivered drug through a Raman spectrometer. Using the method, drug delivery and release can be flexibly controlled by turning on/off the trapping laser beam propagating in the fiber, which can avoid the complex systems and is highly autonomous and controllable. Moreover, the detection of cell activity does not require any dye calibration and processing, and it is noninvasive. In addition, for a single suspension cell, optical trapping of the cell using another fiber tip can overcome the low efficiency of targeted drug delivery and the poor stability of the Raman spectrum caused by Brownian motion of the cell. This all-optical method provides a promising approach to conduct pharmacologic studies with the reaction of cancer cell and drugs at the level of a single cell.
Synthesis and crystal structure of (1E,3E)-2-hydroxy-5-methylisophthalaldehyde O,O-di(2-((((E)-(2-hydroxynaphthalen-1-yl)methylene)amino)oxy)ethyl) dioxime, C35H32N4O7
Authors: Pan Ying-Qi , Yu Meng , Zhang Yu , Dong Wen-Kui
Published: December 2019

C35H32N4O7, triclinic, P1̄ (no. 2), a = 9.3625(6) Å, b = 12.7558(7) Å, c = 14.5965(9) Å, α = 68.833(2)°, β = 80.891(2)°, γ = 69.242(2)°, V = 1519.15(16) Å3, Z = 2, R
gt(F) = 0.0447, wR
ref(F
2) = 0.1500, T = 296(2) K.
New fire-resistant epoxy thermosets: nonisothermal kinetic study and flammability behavior
Authors: Hamciuc Corneliu , Vlad-Bubulac Tachita , Serbezeanu Diana , Carja Ionela-Daniela , Hamciuc Elena , Anghel Ion , Enciu Valentin , Şofran Ioana-Emilia , Lisa Gabriela
Published: December 2019

New fire-resistant thermosets are prepared based on a bisphenol A-epoxy resin which is thermally crosslinked in the presence of dicyandiamide and two phenols containing phosphorus atoms. The thermosets are characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis (TGA), and microscale combustion calorimetry (MCC) tests. A nonisothermal kinetic study is performed based on processing of TGA data applying the method proposed by Vyazovkin. The lifetime prediction analyses establish that the phosphorus-containing polymers could be used at a constant temperature of 200°C up to 200–780 min. The MCC tests reveal an improvement of the flammability behavior, as well as a significant heat release capacity reduction for phosphorus-containing samples compared to the sample which has no phosphorus component.
Characterization and mechanism of accelerated curing of adhesives by
in situ
ultrasonic vibration for bonded joints
Authors: Wang Hui , Yuan Yao , Chen Yizhe
Published: December 2019

Ultrasonic vibration can accelerate the curing of epoxy compounds. Previous studies have not explored the nonthermal effects of ultrasound. In this article, we show the accelerated curing process using in situ ultrasonic vibration that removes the thermal effect. The acceleration mechanism of nonthermal effects is clarified. Bisphenol A epoxy resin/low molecular weight polyamide 650 system was used as the adhesive of the joint, and carbon-fiber-reinforced plastic (CFRP)/aluminum alloy joint was used as the bonding object. Ultrasonic vibration was applied in situ to the CFRP laminate in the joint through an ultrasonic tool head. Fourier transform infrared spectroscopy and differential scanning calorimetry were used to characterize the process of conventional curing and ultrasonic curing of adhesives. Results show that the curing rate of the adhesive can be increased by 2500%. By improving the Kamal model, we describe a new model that can describe the ultrasonic curing process very well. The model shows that ultrasound can reduce the activation energy. Temperature monitoring confirmed that pulsed ultrasound can maintain the temperature of the adhesive stable during the curing process. Dynamic thermomechanical analysis showed that pulsed ultrasound accelerates the curing process and improves the mechanical properties of the adhesive. Ultrasound promotes mass transfer between the resin and the curing agent and increases the collision probability between the reactants, thus increasing the reaction rate.
The effect of specific therapeutic agents on inflammation in sepsis-induced neonatal rats
Authors: Ilhan Nevin , Gul Huseyin Fatih , Susam Solmaz , Ilhan Necip , Bardas Ruken
Published: December 2019

Objective

The aim of this study was to investigate the effect of Thalidomide and Etanercept on inflammation parameters in a neonatal rat sepsis model induced with Lipopolysaccharide (LPS).

Materials and methods

Four-week-old male Wistar Albino rats were used in the experiment. LPS (5 mg/kg) was administered to rats as sepsis-inducing agent and two anti-inflammatory drugs, Thalidomide and Etanercept were given intraperitoneally as chemotherapeutic agents. The septic neonatal rats were treated with Thalidomide (0.5 mg/kg), Etanercept (1 mg/kg), and a combination of the two. All therapeutic agents were injected half an hour after injecting LPS. It took 24 h to perform the entire experiment. Whereupon, liver tissues of the animals were removed, presepsin of liver tissue and NF-κB levels were measured by ELISA analysis and NF-κB protein expression levels were determined by Western blotting.

Results

A significant increase was detected in presepsin and NF-κB levels in LPS group compared to sham and treatment groups. In Western Blot evaluations, there was a significant decrease in the expression of NF-κB protein in treatment groups compared to sepsis group.

Conclusions

It was observed that Thalidomide and Etanercept had potential effects on the treatment of neonatal sepsis.
A New Class with Decreasing Failure Rate Based on Countable Mixture and Its Application to Censored Data
Authors: Mohammed B. I. , Abu-Youssef S. E. , Sief M. G.
Published: December 2019

A three-parameter generalized Poisson Lomax distribution, which contains two-parameter Lomax distribution as a special case, has to be obtained by a countable mixture with Poisson distribution. The mathematical attributes, as behavior of density and failure rate functions, compounding, moments, moment generating functions, and mean residual life, of this model and the strength-stress reliability function R=P(X>Y) are studied. Additionally, the maximum likelihood estimation of the new model parameters is derived. Lastly, the practical performance of the new model is demonstrated using censored and complete data sets with simulation study.
The Artificial Cell, the Semipermeable Membrane, and the Life that Never Was, 1864–1901
Authors: Liu Daniel
Published: December 2019

Since the early nineteenth century, a membrane or wall has been central to the cell’s identity as the elementary unit of life. Yet the literally and metaphorically marginal status of the cell membrane made it the site of clashes over the definition of life and the proper way to study it. In this article I show how the modern cell membrane was conceived of by analogy to the first “artificial cell,” invented in 1864 by the chemist Moritz Traube (1826–1894), and reimagined by the plant physiologist Wilhelm Pfeffer (1845–1920) as a precision osmometer. Pfeffer’s artificial cell osmometer became the conceptual and empirical basis for the law of dilute solutions in physical chemistry, but his use of an artificial analogue to theorize the existence of the plasma membrane as distinct from the cell wall prompted debate over whether biology ought to be more closely unified with the physical sciences, or whether it must remain independent as the science of life. By examining how the histories of plant physiology and physical chemistry intertwined through the artificial cell, I argue that modern biology relocated vitality from protoplasmic living matter to non-living chemical substances—or, in broader cultural terms, that the disenchantment of life was accompanied by the (re)enchantment of ordinary matter.
Heteroglossia of History
Authors: Bui Long
Published: December 2019

This article considers state-funded films in contemporary Vietnam and the legacy of the Republic of Vietnam (South Vietnam), which fell to communist forces in 1975. From a close reading of films produced on the thirtieth anniversary of the end of the war, the article deciphers complicated meanings about national identity, history, and gender. In this new political economic context, the possibilities for remembering the southern regime—including its people and veterans—remains open and closed. Through the framework of heteroglossia of history, the co-presence of competing viewpoints within cinematic texts points to the complexity of an ever-changing Vietnam.
Writing to Remember
Authors: Tran Qui-Phiet
Published: December 2019

This essay addresses the controversial reception of Bảo Ninh’s novel Nỗi buồn chiến tranh [The Sorrow of War] in Vietnam and argues that the novel was perhaps the most important fictional work since Đổi Mới [Renovation]. By overlooking the tenets of socialist realism, the book deals with the war and its aftermath with a candor, eloquence, and anguish that have no parallel in modern Vietnamese literature. The novel’s important questions—memory, time, and writing—can be explained in light of Mikhail Bakhtin’s theory of the chronotope.
ДИТИНА ЯК СУБ’ЄКТ ЕСТЕТИЧНОГО ВИХОВАННЯ В КОНТЕКСТІ ВИКЛИКІВ СЬОГОДЕННЯ
Authors: Sirant Nelia
Published: December 2019

Стаття присвячена висвітленню проблеми естетичного виховання особистості дитини в контексті викликів сьогодення. Автор зазначає, що нині проблема естетичного виховання особистості набуває особливого значення, оскільки загострюються суспільні суперечності, втрачаються загальнолюдські цінності, життєві ідеали дітей та юнацтва. З погляду психології та педагогіки естетичне виховання є актуальною, проте все ж недостатньо дослідженою проблемою. Неупереджений аналіз засвідчує, що погляди вчених на цю важливу проблему неоднозначні, тому утворюють мозаїчну картину на рівні теоретико-емпіричних міркувань.

Мета статті полягає в аналізі теорії естетичного виховання зростаючої особистості, узагальненні психолого-педагогічної та науково-методичної літератури з проблеми, визначенні теоретико-методичних засад дослідження, виокремленні ефективних умов естетичного виховання дітей. Під час роботи над публікацією використано метод історико-педагогічної ретроспективи для з’ясування еволюції поглядів науковців, педагогів на проблему естетичного виховання школярів, теоретичного аналізу, синтезу та узагальнення для виокремлення ефективних умов естетичного виховання зростаючого покоління.

Проаналізовано елементи естетичної культури як важливого складника всебічного розвитку особистості. Доведено, що характер і ступінь розвитку естетичного почуття і естетичного смаку, їх виховання є важливим чинником формування естетичної культури особистості. Автором відзначено, що проблема виховання естетичної культури школярів є надзвичайно актуальною і необхідною для подальшого вивчення та наукового обґрунтування.
FEATURES OF USING METHODS AND FORMS OF THE TEACHING ORGANIZATION IN A SMALL SCHOOL (2ND HALF OF 20TH CENTURY) AND THEIR IMPROVEMENT IN MODERN CONDITIONS
Authors: Prokopiv Liubov
Published: December 2019

This article is about methods and forms of organization of training in a small school. The problem is actualized in the context of the adopted strategy for modernizing general secondary education, namely the Concept of the New Ukrainian School, in accordance with which the restructuring of the educational sector is being carried out in the rural areas as well. The purpose of the article is to identify features of using methods and forms of teaching organization in a small school (2nd half of the 20th century) and effective methods and forms of teaching organization at the present stage. The article has the following tasks: to describe the methods of teaching organization in a small school in accordance with the selected stages; to specify the basic forms of teaching organization in small schools of the studied period; to identify the effective aspects of implementing the partnership pedagogy in the Carpathian educational space.

In order tosolve the research tasks, the following theoretical methods were used: analysis and systematization of psychological, pedagogical and methodical literature; analysis of archival, sources sociological surveys, questionnaires and interviews

The author conducted questionnaires, surveys and interviews confirmed the effectiveness of the innovative teaching methods selected for implementation in the operation of a small school.
КАРПАТИ ТА ЇХ ВПЛИВ НА ФОРМУВАННЯ МЕНТАЛЬНОСТІ ГУЦУЛІВ
Authors: Khrushch Olena
Published: December 2019

У статті обґрунтовується ідея впливу природного середовища, у даному випадку гірського, на формування особистості жителів гір, їх ментальності. Саме від навколишнього природного і соціального середовища, способу господарювання, традицій і звичаїв, вірувань, культури життєдіяльності і спілкування залежить формування психології горянина, його менталітет.

Досліджуючи проблему впливу гірського середовища на розвиток та формування ментальності горян, ми звертаємо увагу на те, що життя спільноти в горах сьогодні вирізняється високою духовністю, а не розвинутими технологіями, а також багатими своєрідними традиціями, які необхідно поєднати з інноваційними видами і методами діяльності. Дослідники намагаються вникнути в реальний процес збалансування технологічної раціональності і ще не втраченої духовності, сьогоднішнього прагматизму і романтизму гірських спільнот, наступальної підприємливості і природолюбності мешканців гір.

Для гуцульського менталітету характерне особливе осмислення природи та ставлення до неї. Між ментальністю і ставленням людей до природи існують тісні і непрості взаємини. Люди залежать від природи, природа – від людей. На це звертали увагу ще давньогрецькі мислителі.

На думку автора дослідження, на формування ментальності такої специфічної етноспільноти, як гуцули, не можуть не вплинути сили природи. З давніх-давен по високогір’ю розселялись люди сміливі, сильні і незалежні. Боротьба із силами природи, специфічна система виховання, що ґрунтувалась на засадах етнопедагогіки, трудових традицій і народних звичаїв, – усе це формувало почуття незалежності і власної гідності.
ЗАСТОСУВАННЯ МЕТОДУ STEM-ПРОЕКТІВ У ПРОЦЕСІ ФОРМУВАННЯ ДОСЛІДНИЦЬКИХ УМІНЬ МАЙБУТНІХ УЧИТЕЛІВ ПОЧАТКОВОЇ ШКОЛИ
Authors: Ignatenko Nataliya , Melnychenko Lyudmyla
Published: December 2019

У статті методологічно обґрунтовано та визначено дидактичний потенціал методу STEM-проектів у процесі формування дослідницьких умінь майбутніх учителів початкової школи, що актуально у контексті Нової української школи та підготовки студентів до проведення досліджень із використанням інноваційних інструментів. Із цією метою застосовано методи контент-аналізу та узагальнення зарубіжного педагогічного досвіду.

Охарактеризовано сутність дослідницьких умінь як одного зі складників професійної компетентності майбутніх учителів початкової школи та процесу їх формування. Розкрито дидактичне значення методу STEM-проектів (STEM Project Based Learning, STEM PBL) та його характерну ознаку – чітко виражений інтегрований підхід до виконання проекту. Встановлено, що у процесі формування дослідницьких умінь студентів спеціальності «Початкова освіта» метод STEM-проектів виконує такі функції: практико зорієнтовану, пізнавальну, комунікативну, цифрову, розвивально-виховну.

Визначено, що застосування методу STEM-проектів у процесі формування дослідницьких умінь майбутніх учителів початкової школи має відповідати критеріям цілеспрямованості, складності, професійної спрямованості та вимогам, серед яких: актуальність і дослідницький характер теми проекту; чітко визначені в навчальній програмі місце та час його виконання; відповідність проблеми дослідження напряму підготовки студентів; закладені у меті та завданнях можливості вивчення об’єкта, процесу чи явища на основі інтегрованого підходу; забезпечення взаємозв’язку теоретичних знань із практикою. Розроблено системний варіант інтеграції STEM-галузей за темою проекту «Критичне мислення як одне з ключових умінь у ХХІ столітті».

З’ясовано, що застосування STEM-проектного навчання сприяє підготовці майбутнього компетентного вчителя-дослідника, тому актуальним напрямом є вивчення дидактичного потенціалу STEM у процесі формування дослідницьких умінь студентів спеціальності «Початкова освіта».
СУТНІСТЬ ІННОВАЦІЙНИХ ТЕХНОЛОГІЙ НАВЧАННЯ У СУЧАСНІЙ НАУКОВІЙ ЛІТЕРАТУРІ
Authors: Bandura Liliia
Published: December 2019

Автор розкриває актуальність питання інноваційних технологій навчання у науковій літературі. У статті проаналізовані інноваційні педагогічні технології як новостворені або вдосконалені педагогічні системи, що забезпечують високий рівень навчально-виховного процесу. У праці зазначено, що стан сучасної освіти залежить від їх ефективності та новаторства. Для того, щоб розвивати інноваційні технології та впроваджувати їх у навчальний процес, необхідно добре проаналізувати їхнє значення. Експериментальне дослідження, проведене нами в ході спілкування з студентами 3-го курсу, дозволяє проаналізувати рівень усвідомлення ними основних понять їхньої майбутньої професійної діяльності. Детальний аналіз та порівняння тлумачень різних авторів даного поняття дозволяє краще пізнати його сутність та подати власне. Таку інформацію вважаємо корисною в розвитку освіти загалом та навчально-виховному процесі зокрема, оскільки вперше виведено цілісне значення поняття «інноваційні педагогічні технології». За концепцією «Нової української школи» прогресивний розвиток освіти можливий тільки за якісної підготовки майбутніх фахівців, що з використанням інноваційних педагогічний технологій матиме успішний результат. Метою статті є розкрити сутність поняття «інноваційні педагогічні технології», використовуючи інформацію з найновіших публікацій з даної теми. Автор використав методи навчання: аналіз та узагальнення інформації з використаних джерел, порівняння та систематизація, експеримент та спостереження.
FSHR-1/GPCR Regulates the Mitochondrial Unfolded Protein Response in Caenorhabditis elegans
Authors: Kim Sungjin , Sieburth Derek
Published: December 2019

The mitochondrial unfolded protein response (UPRmt) is an evolutionarily conserved adaptive response that functions to maintain mitochondrial homeostasis following mitochondrial damage. In Caenorhabditis elegans, the nervous system plays a central role in responding to mitochondrial stress by releasing endocrine signals that act upon distal tissues to activate the UPRmt. The mechanisms by which mitochondrial stress is sensed by neurons and transmitted to distal tissues are not fully understood. Here, we identify a role for the conserved follicle-stimulating hormone G protein-coupled receptor, FSHR-1, in promoting UPRmt activation. Genetic deficiency of fshr-1 severely attenuates UPRmt activation and organism-wide survival in response to mitochondrial stress. FSHR-1 functions in a common genetic pathway with SPHK-1/sphingosine kinase to promote UPRmt activation, and FSHR-1 regulates the mitochondrial association of SPHK-1 in the intestine. Through tissue-specific rescue assays, we show that FSHR-1 functions in neurons to activate the UPRmt, to promote mitochondrial association of SPHK-1 in the intestine, and to promote organism-wide survival in response to mitochondrial stress. We propose that FSHR-1 functions cell nonautonomously in neurons to activate UPRmt upstream of SPHK-1 signaling in the intestine.
La diferencia entre conservar y aprovechar racionalmente los recursos del mar
Authors: Ramírez Arnulfo
Published: December 2019

No disponible/Not available
Limitaciones en la definición y la aplicación de estándares internacionales de exposición laboral a agentes tóxicos en la industria
Authors: Vega Sileny
Published: December 2019

No disponible/Not available
Después de ECO'92
Authors: Alfaro G. Maria Del Rosario
Published: December 2019

No disponible/Not available
La Conservación Ecológica: Deber fundamental de nuestra generación
Authors: Calderón Fournier Rafael Angel
Published: December 2019

No disponible/Not available
La fertilización con N-P-K en fórmulas completas para Cupressus lusitana Miller
Authors: Rodríguez Alvarez Dora , Fonseca González William
Published: December 2019

No disponible/Not available
Composición química de la lluvia en Cuba
Authors: Rodríguez C. Arturo E.
Published: December 2019

No disponible/Not available
La cacería en Costa Rica y sus posibilidades
Authors: C. Sáenz Joel , Di Mare María Isabel
Published: December 2019

No disponible/Not available
Algunas características de la deposición del nitrógeno atmosférico en Cuba
Authors: Cuesta Santos Osvaldo , González González María , Collazo Aranda Arnaldo
Published: December 2019

No disponible/Not available
Estrategia mundial para la conservación
Authors: Alfaro María Del Rosario
Published: December 2019

No disponible/Not available
Escacez y sobrevivencia en Centroamérica
Authors: Baudoin Mario
Published: December 2019

No disponible/Not available
Movilidad de herbicidas en suelos volcánicos de Costa Rica
Authors: Montes de Oca Paulina
Published: December 2019

No disponible/Not available
Ensayo de germinación de Diphysa robinioides Benth, bajo tres tipos de coberturas
Authors: Mora Ruben , Rodríguez Dora
Published: December 2019

No disponible/Not available
Notas introductorias al estudio de los problemas de planificación del desarrollo científico y tecnológico
Authors: Fernández Francisco , Fernández Luis Fernando
Published: December 2019

No disponible/Not available
Ensayos de aclareo en plantaciones de Tectona grandis L.F. en Cóbano de Puntarenas, Costa Rica
Authors: Chaves S. Eladio , Chinchilla M. Orlando
Published: December 2019

No disponible/Not available
Mapeo de los humedales de Palo Verde, Costa Rica
Authors: Bravo Juan , Flores Teresita , Mora Ileana
Published: December 2019

No disponible/Not available
Paisaje y artificialización del ecosistema en sarapiquí
Authors: Arrieta Chavarría Omar
Published: December 2019

No disponible/Not available
Unidades de medida para madera en troza en Costa Rica
Authors: Jiménez A. Sergio
Published: December 2019

No disponible/Not available
La artificialización ecosistémica en el paisaje central de sarapiquí
Authors: Mora Castellanos Eduardo
Published: December 2019

No disponible/Not available
Considerations for psychedelic therapists when working with Native American people and communities
Authors: Eriacho Belinda
Published: December 2019

Although Native American communities are unique in their beliefs, traditions, and languages, there are some fundamental common belief systems shared by most Native American cultures. Therapists and other practitioners engaging in a healing relationship with Native Peoples should be aware of these fundamental aspects of the Native American culture. This includes trust/respect, confidentiality outside of the context therapeutic setting, culturally based therapy that is inclusive of Native American traditions, and culture, and making efforts to gain an understanding of the culture with which one will be interacting.
Professores Coordenadores sob o olhar dos professores
Authors: Oliveira Luciane Aparecida de , Chaluh Laura Noemi
Published: December 2019

Neste trabalho socializamos recorte de uma pesquisa que objetivou compreender a constituição dos professores coordenadores e da coordenadora pedagógica, considerando suas atribuições (administrativas e pedagógicas) e as relações que estabelecem com a comunidade escolar (gestão, professores, funcionários, alunos e pais) e com a Secretaria Municipal de Educação (SME) de uma cidade do interior do estado de São Paulo. A pesquisa tematizou os desafios que esses sujeitos enfrentavam e que circulavam no interior de um Grupo de Estudos, sob a responsabilidade da coordenadora pedagógica vinculada a SME. A perspectiva teórico-metodológica assumida foi a pesquisa narrativa. Neste trabalho, socializamos levantamento feito pelos professores coordenadores nas respectivas escolas que dizem das percepções dos professores em relação às atribuições dos primeiros. Explicitamos as lições aprendidas pela coordenadora pedagógica, responsável pelo Grupo de Estudos, que evidenciam as concepções de formação dos professores coordenadores e suas implicações ao pensar nos mesmos enquanto articuladoras da formação no contexto escolar. Para compor o trabalho trazemos os registros dos professores das escolas e da coordenadora pedagógica. O trabalho contribui para repensar os processos formativos no contexto de redes de ensino.
Natureza das atividades laboratoriais de investigação nos Manuais Escolares de Físico-Química do 8.º Ano
Authors: Coelho da Silva José Luís De Jesus , Duarte Joana Margarida Coelho , Faria Durães Mário Miguel Linhares Pereira
Published: December 2019

As atividades laboratoriais de investigação, concebidas no âmbito da ciência escolar, são apontadas como as mais adequadas para a promoção do desenvolvimento da aprendizagem dos processos científicos e, consequentemente, da capacidade de indagação/investigação. Contudo, podem também contribuir para a aprendizagem do conhecimento substantivo. É no âmbito deste enquadramento teórico que se procede à análise de conteúdo da natureza e grau de abertura deste tipo de atividades nos oito manuais escolares portugueses de Físico-Química do 8.º ano de escolaridade. Neste conjunto, identificaram-se 22 atividades laboratoriais do tipo investigação. A relevância conferida a este tipo de atividades é limitada na maioria dos manuais escolares, dado estarem presentes em número reduzido. Constata-se que a promoção do desenvolvimento da capacidade de investigação não é o papel primordial que lhes é atribuído, estando direcionadas principalmente para a (re)construção do conhecimento substantivo. Mostra-se, assim, necessária uma reconfiguração das atividades laboratoriais, incrementando as investigações e promovendo intencional e explicitamente a aprendizagem dos processos científicos, numa aproximação à metodologia científica.
O artefacto “representações visuais” como ferramenta de ensino em matemática
Authors: Montenegro Paula
Published: December 2019

Este estudo faz parte de uma investigação mais ampla cujo objetivo geral é explorar modos de aumentar o impacto do uso de representações visuais como ferramenta epistémica no ensino e na aprendizagem de diferentes domínios matemáticos do 2.º ciclo do Ensino Básico. O objetivo deste estudo é analisar duas situações de ensino e aprendizagem em que se utilizou o artefacto representações visuais como ferramenta de aprendizagem. Os participantes são 17 alunos com idade média de 11,3 anos e a sua professora. Os alunos resolveram duas tarefas de áreas de figuras planas. Os dados foram recolhidos a partir da gravação áudio das aulas, dos registos escritos dos alunos, dos planos de aula e do diário da professora. Os resultados mostraram que a ferramenta tratamentos visuais potenciou transformações de representações. Concluímos que esta ferramenta pode ser uma técnica à disposição do professor para levar os alunos a construir o seu conhecimento, proporcionando uma mediação com múltiplas representações.
Eficácia da mediação do professor no ensino da estrutura corpuscular da matéria
Authors: Araújo Fatima Maria , Lopes Bernardino , Soares Armando , Cravino José
Published: December 2019

O objetivo deste estudo foi investigar a influência/eficácia da mediação do professor na aprendizagem da estrutura da matéria e das mudanças de estado físico a nível microscópico, por alunos do 5.ºano de escolaridade. O estudo teve como base duas questões de investigação: (1) “Qual a influência/eficácia da mediação do professor, em tarefas com igual orientação, na compreensão das mudanças de estado físico da matéria, a nível corpuscular, por alunos do 5.º ano de escolaridade?” (2) “Que avaliação o aluno atribui à autonomia dada pela professora?” O estudo foi realizado em dois grupos de 15 alunos cada. Fez-se a recolha de dados sobre o ensino e a aprendizagem em sala de aula em particular gravações áudio, imagens e trabalhos dos alunos. Com esses dados construíram-se narrações multimodais, cuja análise permitiu verificar que a mediação do professor foi diferente nos dois grupos e que essa diferença pode ter influenciado o grau de desempenho dos alunos e a perceção da autonomia facultada pela professora.
Princesas Disney e cinema: representações do gênero feminino
Authors: De Matos Ferreira Verônica Caroline , Gonçalves Josiane Peres
Published: December 2019

Os filmes dos Estúdios Disney sobre princesas exercem influência no processo de construção e reprodução de estereótipos relacionados aos gêneros, principalmente feminino. Com base nesse pressuposto, a pesquisa busca identificar as representações de gênero retratadas pelas princesas de duas versões dos filmes Cinderela e a Bela e a Fera, destacando a opinião de algumas adolescentes sobre as narrativas e protagonistas femininas. O aporte teórico baseia-se em estudos relacionados ao cinema e sua influência, a construção social do gênero feminino e as analogias das representações predominantes nas versões dos filmes Cinderela de 1950 com a de 2015 e A Bela e a Fera de 1991 com a versão de 2017. A pesquisa de campo foi realizada com cinco adolescentes do gênero feminino, com idades entre 13 e 15 anos de idade, por meio de questionários e roda de conversa, após assistir as duas últimas versões dos filmes mencionados. Os resultados apontam que há um avanço em relação à representação feminina, contudo ainda se reforça os estereótipos relativos à juventude, magreza, beleza, bondade, entre outros, os quais exercem influência na formação das novas gerações, como é o caso das cinco adolescentes que sonham com o príncipe e se identificam com as princesas da Disney.
PD-L1 Expression on Circulating Tumor Cells May Be Predictive of Response to Pembrolizumab in Advanced Melanoma: Results from a Pilot Study
Authors: Khattak Muhammad A. , Reid Anna , Freeman James , Pereira Michelle , McEvoy Ashleigh , Lo Johnny , Frank Markus H. , Meniawy Tarek , Didan Ali , Spencer Isaac , Amanuel Benhur , Millward Michael , Ziman Melanie , Gray Elin
Published: December 2019

Background

PD-1 inhibitors are routinely used for the treatment of advanced melanoma. This study sought to determine whether PD-L1 expression on circulating tumor cells (CTCs) can serve as a predictive biomarker of clinical benefit and response to treatment with the PD-1 inhibitor pembrolizumab.

Methods

Blood samples were collected from patients with metastatic melanoma receiving pembrolizumab, prior to treatment and 6–12 weeks after initiation of therapy. Multiparametric flow cytometry was used to identify CTCs and evaluate the expression of PD-L1.

Results

CTCs were detected in 25 of 40 patients (63%). Patients with detectable PD-L1+ CTCs (14/25, 64%) had significantly longer progression-free survival (PFS) compared with patients with PD-L1− CTCs (26.6 months vs. 5.5 months; p = .018). The 12-month PFS rates were 76% versus 22% in the PD-L1+ versus PD-L1− CTCs groups (p = .012), respectively. A multivariate linear regression analysis confirmed that PD-L1+ CTC is an independent predictive biomarker of PFS (hazard ratio, 0.229; 95% confidence interval, 0.052–1.012; p = .026).

Conclusion

Our results reveal the potential of CTCs as a noninvasive real-time biopsy to evaluate PD-L1 expression in patients with melanoma. PD-L1 expression on CTCs may be predictive of response to pembrolizumab and longer PFS.
Novel Risk Scoring System for Patients with Metastatic Renal Cell Carcinoma Treated with Immune Checkpoint Inhibitors
Authors: Martini Dylan J. , Liu Yuan , Shabto Julie M. , Carthon Bradley C. , Hitron Emilie Elise , Russler Greta Anne , Caulfield Sarah , Kissick Haydn T. , Harris Wayne B. , Kucuk Omer , Master Viraj A. , Bilen Mehmet Asim
Published: December 2019

Background

The International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) criteria are the gold standard for risk-stratifying patients with metastatic renal cell cancer (mRCC). We developed a novel risk scoring system for patients with mRCC treated with immune checkpoint inhibitors (ICIs).

Methods

We performed a retrospective analysis of 100 ICI-treated patients with mRCC at Winship Cancer Institute from 2015 to 2018. Several baseline variables were collected, including markers of inflammation, body mass index (BMI), and sites of metastatic disease, and all were considered for inclusion in our risk scoring system. Upon variable selection in multivariable model, monocyte-to-lymphocyte ratio (MLR), BMI, and number and sites of metastases at baseline were used for risk score calculation. Patients were categorized using four-level risk groups as good (risk score = 0), intermediate (risk score = 1), poor (risk score = 2), or very poor (risk score = 3–4). Cox's proportional hazard model and the Kaplan-Meier method were implemented for survival outcomes.

Results

Most patients were male (66%) with clear cell renal cell carcinoma (72%). The majority (71%) received anti–programmed cell death protein-1 monotherapy. Our risk scoring criteria had higher Uno's concordance statistics than IMDC in predicting overall survival (OS; 0.71 vs. 0.57) and progression-free survival (0.61 vs. 0.58). Setting good risk (MLR <0.93, BMI ≥24, and D_Met = 0) as the reference, the OS hazard ratios were 29.5 (95% confidence interval [CI], 3.64–238.9), 6.58 (95% CI, 0.84–51.68), and 3.75 (95% CI, 0.49–28.57) for very poor, poor, and intermediate risk groups, respectively.

Conclusion

Risk scoring using MLR, BMI, and number and sites of metastases may be an effective way to predict survival in patients with mRCC receiving ICI. These results should be validated in a larger, prospective study.