bluuebunny/crossref_metadata_2025 huggingface dataset:
Privacy preserving on personalized medical data in cloud IoT using Extended Fully Homomorphic Encryption
Authors: Bedi Pradeep , Goyal S B
Published: May 2022

Transition of healthcare to digital platforms is necessary for the present era to provide a better diagnosis with reduced operational cost. Digital platform makes the patient data available in an appropriate time. Cloud computing in health care applications senses the data through IoT modules and stored in the cloud. Manipulating medical data needs an essential protection mechanism to ensure data privacy. To reduce the privacy issues, encryption algorithms are preferred generally but their efficiency needs to be improved without breaking the data confidentiality. This research work proposed an Extended Fully Homomorphic Encryption (EFHE) scheme to preserve medical data privacy. Parameters such as Signal to Noise Ratio, Peak Signal to Noise Ratio, Mean Square Error, encoding, and decoding time are considered for analysis and conventional homomorphic and fully homomorphic algorithms are used to compare with the proposed research model to validate the superior performance of the proposed encryption scheme.
Acupuncture Exerts Antidepressant Effects in Rats of Chronic Unpredictable Mild Stress: The Involvement of Inflammation in Amygdala and Brain-Spleen Axis
Authors: Chen Wenjie , Chen Yiping , Cheng Wenjing , Li Peng , Shen Junliang , Tong Tao , Yan Simin , Huang Zichun , Li Jiawei , Huang Shuqiong , Meng Xianjun
Published: May 2022

Background
Acupuncture has shown antidepressant effects in rats with chronic unpredictable mild stress (CUMS). However, the mechanisms of antidepressant effects of acupuncture still need to be explored. In the study, acupuncture was applied to a rat depression model of CUMS, high-mobility group box 1(HMGB1) / toll-like receptor 4 (TLR4) and brain-spleen axis were assessed.
Methods
Male Sprague Dawley (SD) rats were exposed to CUMS with two stressors per day for 28 days. In the meantime, manual acupuncture (at GV16 and GV23 acupoints, once every other day) and fluoxetine gavage (2.1 mg/kg, 0.21 mg/mL) were administered daily post-CUMS stressors. Behavioral tests and biological detection methods were conducted in sequence to evaluate depression-like phenotype in rats.
Results
The results showed CUMS induced depression-like behaviors, hyper-activation of HMGB1/TLR4 signaling pathway, elevated inflammation in amygdala and peripheral blood, and hyperactivation of hypothalamic-pituitary-adrenal (HPA) axis. These changes could be reversed by acupuncture to varying extents.
Conclusion
Acupuncture ameliorated depression-like symptoms induced by CUMS, possibly via regulating inflammation mediated by HMGB1/TLR4 signaling pathway in amygdala and peripheral blood circulation, thus improving behavioral outcomes through brain-spleen axis and HPA axis regulation.
Phase Congruency Based on Derivatives of Gaussian Function: An Efficient Feature Map for Image Quality Assessment
Authors: Chen Congmin , Mou Xuanqin
Published: May 2022

Image quality assessment (IQA) has become a hot issue in image processing, which aims to evaluate the quality of images automatically by a metric being consistent with subjective evaluations. Though deep learning based techniques have been applied to IQA models to achieve much progress, conventional IQA models that adopt deliberately designed features are still meaningful because by which we can learn what features are quality-aware and hence understand more about the way we improve image quality by enhancing quality-aware features. The first stage of conventional IQA model design is the quality-aware feature selection. Phase congruency (PC), as one of efficient saliency maps, which takes advantages of early visual feature, operates in frequency domain to measure local structure such as edges, corners, lines, etc. by computing the local amplitude and local energy in multiple scales. Conventional local PC feature is calculated with log-Gabor based filtration in several orientations, and is usually combined with other features in quality estimating. Recently, researchers suggested that spatially circular symmetric filters, such as gradient magnitude (GM) and Laplacian of Gaussian (LoG), are highly-efficient quality features that have been widely used in various IQA model designs. By considering the first-order derivative property of GM and the second-order derivative property of LoG, the two features are a suitable pairs for PC compositions while keeping the circular symmetric characteristic. Therefore, we use GM and LoG to construct a novel PC feature map and only use this feature map to build a full-reference (FR) IQA model, which is proved to be state-of-the-art on three benchmark databases. Furthermore, we replace the PC algorithm in the state-of-the-art FSIM metric with our PC computation, which achieves improved performance. This study suggests that the proposed circular symmetric PC feature is a high efficient quality feature and can be exclusively used in IQA model designs.
Humulus lupus extract rich in Xanthohumol reduces the risk of a fatal clinical course in critically ill patients treated for COVID-19
Authors: Dabrowski Wojciech , Gagos Mariusz , Siwicka-Gieroba Dorota , Piechota Mariusz , Siwiec Jan , Bielacz Magdalena , Kotfis Katarzyna , Stepulak Andrzej , Grzycka-Kowalczyk Luiza , Jaroszynski Andrzej , Malbrain Manu LNG
Published: May 2022

Background.
The systemic inflammatory response following severe coronavirus infection (COVID-19) is associated with poor outcome. Several anti-inflammatory medications were studied in COVID-19 patients. Xanthohumol (Xn), a natural extract from hop cones, possesses strong anti-inflammatory and antioxidative properties. The aim of this study was to analyse the effect of Xn on the inflammatory response and the clinical outcome of COVID-19 patients.
Methods
Adult patients treated for acute respiratory failure (PaO2/FiO2 less than 150) were studied. Patients were randomized into two groups: Xn – patients receiving adjuvant treatment with Xn at a daily dose of 4.5 mg/kg body weight for 7 days, and C – controls (patients receiving placebo – NaCl 0.9%). Observations were performed at four time points: immediately after admission to the ICU and on the 3rd, 5th and 7th days of treatment. The inflammatory response was assessed based on the plasma IL-6 concentration, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), C-reactive protein (CRP) and D-dimer levels. The mortality rate was determined 28 days after admission to the ICU.
Results
Seventy-two patients were eligible for the study, and 50 were included in the final analysis. The mortality rate was significantly lower and the clinical course was shorter in the Xn group compared to controls (20% vs. 48%, p < 0.05, and 9 ± 3 days vs. 22 ± 8 days, p < 0.001). Treatment with Xn decreased plasma IL-6 concentration (p < 0.01), D-dimer levels (p < 0.05) and NLR (p < 0.01) more significantly compared to standard treatment.
Conclusion
Adjuvant therapy with Xn appears to be a promising anti-inflammatory treatment in COVID-19 patients.
Development of prosthetic device based on engineering design approach
Authors: Francisco Marta , Junior Osiris Canciglieri , Okumura Maria Lucia , Santanna Angelo Marcio
Published: May 2022

Engineering design with innovative characteristics that offer additional benefits to the customer is a process consisting of complex activities that require research, planning, and systematic methods. A prominent product development process has been driven by technological innovations used to assist the disabled in acquiring greater autonomy and performing daily tasks. Assistive product development has ensured the disabled more excellent prospects, contributing to providing or expanding the functional abilities of people with disabilities, resulting in the promotion of independent living and inclusion. This paper aims to develop a prosthetic device to aid patients with hand agenesis in practicing swimming based on the engineering design approach. The assistive product development was made based on the four phases: (i) demand perception, (ii) product projection, (iii) product characterization, and (iv) optimization. In addition, it was used for Monte Carlo simulation, multivariate analysis, and tolerance interval analysis techniques in the product development phases. We developed this approach as an alternative to classical engineering design used in the additive manufacturing process for prosthetic devices. The assistive product set aims to significantly stimulate the hand agenesis patient in physical activity, representing one of the doors of entry for social inclusion, providing a better quality of physical and emotional life for the individual with a disability.
Real-time smooth trajectory generation for 3-axis blending tool-paths based on FIR filtering
Authors: Fang Jun , Li Bingran , Zhang Hui , Ye Peiqing
Published: May 2022

3-axis machining tool-paths are generated using computer-aided manufacturing (CAM) systems and programmed by series of G01 codes mixed with long and short segments. The computer numerical control (CNC) system needs to analyze the path information according to the G codes, through the path smoothing, speed planning, and interpolation process, generate the smooth trajectory and ensure the high-order continuity of velocity. This paper proposes a real-time smooth trajectory generation algorithm with simple structure and low calculation for 3-axis blending machining tool-paths. FIR filters are used to generate a smooth trajectory with bounded acceleration in real-time. Due to the delay of the filter, it will inevitably bring contour error. The feed rate is adjusted by considering the influence of the adjacent segments on the contour error in the case of long segments, then this idea is extended to continuous micro-segments. Finally, through the pre-discretization with certain rules, a direct one-step smooth trajectory generation algorithm for the blending tool-paths is realized. The algorithm not only can effectively control the contour error, but also is suitable for blending tool-paths. Consequently, the effectiveness of the proposed algorithms are validated in simulations and also experimentally on a 5-axis machine tool.
Multimodal Interaction Aware Embedding for Location-Based Social Networks
Authors: Yu Ruiyun , Yang Kang , Wang Zhihong , Zhen Shi
Published: May 2022

Location-based social networks (LBSNs) have greatly promoted the development of the field of human mobility mining. However, the sparsity, multimodality and heterogeneity nature of the user check-in data remains a great concern for learning high-quality user or other entities representations, especially in the downstream application tasks, such as point-of-interest (POI) recommendation. Most existing methods focus on user preference modeling based on sequential POI tags without exploring the interaction between different modalities (e.g., user-user interactions, user-timestamp interactions, user-POI interactions, etc.). To this end, we introduce a multimodal interaction aware embedding framework to generate reliable entity embeddings on the heterogeneous socio-spatial network. At its core, first, multi-modal interaction sub-graph sampling techniques are designed to capture the heterogeneous contexts; then, a self-supervised contrastive learning technique is leveraged to extract intra-modality and inter-modality interactions in a light way. We conduct experiments on the next-POI recommendation tasks based on three real-world datasets. Experimental results demonstrate the superiority of our model over the state-of-the-art embedding learning algorithms.
Immediate myeloid depot for SARS-CoV-2 in the human lung
Authors: Magnen Melia , You Ran , Rao Arjun , Davis Ryan , Rodriguez Lauren , Simoneau Camille , Hysenaj Lisiena , Hu Kenneth , Love Christina , Woodruff Prescott , Erle David , Hendrickson Carolyn , Calfee Carolyn , Matthay Michael , Roose Jeroen , Sil Anita , Ott Melanie , Langelier Charles , Krummel Matthew , Looney Mark
Published: May 2022

In the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic1, considerable focus has been placed on a model of viral entry into host epithelial populations, with a separate focus upon the responding immune system dysfunction that exacerbates or causes disease. We developed a precision-cut lung slice model2,3 to investigate very early host-viral pathogenesis and found that SARS-CoV-2 had a rapid and specific tropism for myeloid populations in the human lung. Infection of alveolar macrophages was partially dependent upon their expression of ACE2, and the infections were productive for amplifying virus, both findings which were in contrast with their neutralization of another pandemic virus, Influenza A virus (IAV). Compared to IAV, SARS-CoV-2 was extremely poor at inducing interferon-stimulated genes in infected myeloid cells, providing a window of opportunity for modest titers to amplify within these cells. Endotracheal aspirate samples from humans with the acute respiratory distress syndrome (ARDS) from COVID-19 confirmed the lung slice findings, revealing a persistent myeloid depot. In the early phase of SARS-CoV-2 infection, myeloid cells may provide a safe harbor for the virus with minimal immune stimulatory cues being generated, resulting in effective viral colonization and quenching of the immune system.
A New Investigation into Al-Cu Dissimilar Joint by SiC Nanoparticle during the FSSW Process: Influence of Rotational Speed and Dwell Time
Authors: Alizadeh Mehdi , Bagheri Behrouz , Shamsipur Ali , Abdollahzadeh Amin , Mirsalehi Seyyed Ehsan
Published: May 2022

Friction stir spot welding (FSSW) was implemented to joining of AA2024-T4 and commercially pure copper with SiC nanoparticles as a reinforcing particle for the first time. The influence of welding parameters namely rotational speed (1300, 1600, and 1900 rpm) and dwell time (2, 4, and 6 s) on microstructure and mechanical characteristics of the welds were studied. For this purpose, macro-and microstructures, shear tensile strength, and microhardness of the joints were investigated. The grain size of the stir zone on copper and aluminum sides decreases from 45.1 to 10.5 µm and 62.2 to 14.5 µm as rotational speed and dwell time decrease. Furthermore, the size of the weld zone increased as rotational speed and dwell time increased. The results revealed the formation of AlCu and Al2Cu intermetallic compounds in the weld zone. The thickness of the IMCs layer in the interface joint increases as input heat increases. It was found that there is a direct relationship between the shear strength of weld specimens and rotational speed and dwell time during the FSSW process. The microhardness value of the joint zone was significantly improved from HV 122 to HV 156 with an increase in rotational speed and dwell time.
Prognostic significance of tumor-associated neutrophils and circulating neutrophils in glioblastoma, IDH wild-type
Authors: Wang Xuezhen , Li Xiaoxia , Wu Yufan , Hong Jinsheng , Zhang Mingwei
Published: May 2022

Background
Tumor-associated neutrophils (TANs) in the tumor microenvironment are prognostic biomarkers in many malignancies. However, the prognostic value of TANs in glioblastoma, IDH wild-type remains poorly studied. We analyzed correlations of TANs and peripheral blood neutrophils prior to radiotherapy with overall survival (OS) in glioblastoma.
Methods
RNA-seq expression profiles of patients with newly diagnosed glioblastoma, IDH wild-type were extracted from The Cancer Genome Atlas (TCGA), and the Chinese Glioma Genome Atlas (CGGA). TAN infiltration was inferred using CIBERSORTx algorithm. Neutrophil counts prior to radiotherapy in newly diagnosed glioblastoma, IDH wild-type were obtained from the First Affiliated Hospital of Fujian Medical University. The prognostic value of TANs and peripheral blood neutrophils before radiotherapy was investigated using Kaplan-Meier analysis and Cox proportional hazards models. The robustness of these findings was evaluated by sensitivity analysis, and E values were calculated.
Results
A total of 113 and 173 individuals with glioblastoma, IDH wild-type were identified from the TCGA and CGGA cohorts, respectively. High infiltration of TANs was of prognostic of poor OS in TCGA (HR = 1.811,95% CI: 1.048–3.128) and CGGA (HR = 1.572, 95% CI: 1.046–2.365). Levels of peripheral blood neutrophils before radiotherapy (HR = 2.073, 95% CI: 1.077–3.990) were independently associated with poor prognosis. Sensitivity analysis determined that the E-value of high TANs infiltration was 2.38 and 2.52 in the TCGA and CGGA cohorts.
Conclusions
TANs and peripheral blood neutrophil levels before radiotherapy are prognostic of poor outcomes in glioblastoma, IDH wild-type.
Lack of Coherence Between Commercial and Scientific Names for Timber Species: Implications for the Sustainable Exploitation of Andoung in Gabon
Authors: Mboma R , Chevillotte H , Doumenge C , Labat J-N† , PP Lowry II
Published: May 2022

The lack of coherence between the trade names applied to commercially sold wood and the scientific names of the species involved may be contributing to the degradation and loss of biodiversity. To test this, a study was conducted in nine forestry concessions in Gabon to evaluate how well tree spotters were able to recognize and identify the group of nine species referred to by the commercial name andoung. Only 65% of the 308 trees recognized by the spotters as andoungs belonged to this group; this includes species in two genera, Aphanocalyx and Bikinia, both of which are often confused with members of other, more distantly related genera of Fabaceae. Trees assigned a commercial name with a qualifying epithet, corresponding to a particular species of andoung, were correctly identified only 11% of the cases. The inability to distinguish among species means that those that are rare and/or have restricted distribution, and may therefore be threatened, are almost certainly being harvested and sold. To improve this situation, we propose several steps designed to favor more accurate in-field identification of andoung species and to promote greater awareness of which species are suitable for sustainable harvested and which ones require legal protection to ensure their survival.
What Is The Agreement Between Intraoperative Fluoroscopy And Postoperative Radiographs In Bernese Periacetabular Osteotomy?
Authors: Peng Jianping , Xiao Fei , Zhu Junfeng , Shen Chao , Li Yang , Han Xiuguo , Cui Yimin , Chen Xiaodong
Published: May 2022

Background
It is important to reorient the acetabular fragment in an optimal position and version to ensure a good long-term outcome after Bernese periacetabular osteotomy (PAO). Unfortunately, the intraoperative balance between overcorrection and undercorrection remains challenging for the surgeon. The purpose of this study was to answer two questions: (1) Does the femoral head coverage measured on intraoperative fluoroscopic images agree with that measured on postoperative radiographs? (2) What is the reliability of intraoperative fluoroscopy in identifying hip center correction in PAO?
Methods
A total of 173 patients (173 hips) who underwent PAO in our center from July 01, 2020, to December 31, 2020, were retrospectively reviewed. Imaging data from 111 patients were included in this study. The analysis included measurement of the lateral center-edge angle (LCEA), acetabular index (AI), anterior wall index (AWI), posterior wall index (PWI), extrusion index (EI), and medial offset distance (MO). These measurements were acquired from intraoperative fluoroscopy and postoperative radiographs and compared using the matched-pairs t test. Significance was determined at a p value of < 0.05. Bland–Altman analysis was used to quantify the agreement between intraoperative fluoroscopy and postoperative radiographs.
Results
The mean (SD) of LCEA, AI, AWI, PWI, EI, and MO obtained on the intraoperative fluoroscopy images were 32.86° (5.73°), 0.66° (5.55), 0.29 (0.10), 0.75 (0.17), 11.15% (6.50%), and 8.49 mm (3.68 mm), respectively. On the postoperative radiographs, the corresponding values were 32.91° (6.31°), 1.63° (5.22°), 0.29 (0.15), 0.85 (0.14), 11.27% (7.36%), and 9.60 mm (3.79 mm). The differences in the LCEA, AWI, and EI acquired from the intraoperative fluoroscopy and the postoperative radiographs were not significant (p = 0.90, 0.95, 0.83, respectively), but those in the AI, PWI, and MO were (p < 0.05). The mean bias (95% limits of agreement) of the LCEA, AI, AWI, PWI, EI, and MO were − 0.04 (-6.85), -0.97 (-7.78), 0 (-0.30), -0.11 (-0.36), -0.12 (-11.92), and − 1.11 (-5.51), respectively.
Conclusion
The LCEA, EI, and AWI can be used to reliably predict postoperative femoral head coverage. The acetabular inclination can be cautiously assessed using AI on intraoperative fluoroscopy. The AWI and PWI demonstrates acceptable agreement between fluoroscopy and radiography in assessing acetabulum version. Although the MO shows slight bias, it can be helpful in positioning the acetabulum properly during PAO.
Immunobiotic bacteria attenuate fibrosis in Non-alcoholic steatohepatitis mice model: molecular insights and therapeutic potential of immunobiotics for the gut-liver axis
Authors: Kanmani Paulraj , Villena Julio , Lim Soo-kyoung , Song Eun-Ji , Nam Young-Do , Kim Hojun
Published: May 2022

Background
Non-alcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease worldwide that can progress to liver fibrosis (LF). Probiotics have beneficial roles in reducing intestinal inflammation and gut-associated diseases, but their effects and mechanisms beyond the gut in attenuating the progression of LF are remains unclear.
Results
We used a diet-induced NASH/LF mouse model to examine the therapeutic potential of immunomodulatory probiotics (immunobiotics) on the attenuation of LF and the underlying mechanisms ameliorating the progression of LF. The results showed that a methionine-choline deficient (MCD) diet resulted in hepatic inflammation, steatosis, increased triglyceride and lipid accumulation, inflammatory immune cells, and fibrosis. Immunobiotics mixtures reduced the MCD-died serum endotoxin, IL-17A, alanine, and aspartate aminotransferase and increased the serum regulatory cytokine and liver weight. Th17 cells, which produce inflammatory cytokine IL-17, on the liver tissues of MCD diet-fed mice were reduced significantly by immunobiotics. The immunobiotics treatment reduced the MCD diet-induced collagen, a-smooth muscle actin, CD68 deposition, and fibrogenic TGF-β signaling activation. The MCD diet reduced gut-barrier integrity, mucin production, and inflammatory cytokines and altered the gut microbiota composition that could be restored by immunobiotics. The administration of immunobiotics increased the aryl hydrocarbon receptors (AhR) pathway activation in both colonic and liver tissues of MCD diet-fed mice.
Conclusions
Our results demonstrate a novel insight into the mechanisms through which immunobiotic administration improves the gut barrier integrity, modulates the gut microbial composition, increases AhR activation, and reduces gut dysbiosis, bacterial translocation, LPS, and inflammatory cytokines levels, which in turn in increases the AhR pathway and inhibits HSCs activation and fibrosis progression beyond the gut in the liver tissue of NASH/LF mice.
Excessive iron in diets promotes kidney fibrosis via disordering the inflammation factors in Sheep
Authors: Sun Fengjiao , An Yuzhi , Zhang Liangyu , Lv Xiaoping , Liu Chaonan , Gao Xueli
Published: May 2022

Iron is a mineral that the body acquires from the environment in order to maintain physiological function; however, excessive iron causes disease. The aim of this work is to investigate the processes by which excessive iron in diets induces kidney fibrosis in sheep by disorders their inflammatory factors. All sheep were fed a basal diet supplemented with 50 (CON), 500 (L-iron), 1000 (M-iron), and 1500 (H-iron) mg Fe/kg as ferrous sulfate monohydrate (FeSO4·H2O), respectively. Hematoxylin-Eosin (H&E), Perls, and Masson staining were used to observe histopatholological alterations; Western blotting, ELISA, and quantitative real-time polymerase chain reaction (qRT-PCR) were used to detect changes in the amounts of key inflammatory factor genes and proteins. As iron intake rose, glomerular cell contents dropped, tubular inflammatory cells infiltrated and fibrin was secreted, collagen fiber deposition and fibrosis have noticeable symptoms. Interleukin-1β (IL-1β), tumour necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) activities were decreased, while interleukin-2 (IL-2), interleukin-6 (IL-6), nuclear factor-κB (NF-κB), and transforming growth factor-β1 (TGF-β1) actvities were increased. Excessive iron disorders inflammatory factor secretion, triggers an inflammatory response, and promotes the development of renal fibrosis, according to this study.
Image encryption based on chaos, elliptic curve, dynamic S-boxes and variable permutations
Authors: Garcia Victor Manuel Silva , Garcia-Cuahutle Kevin Brando , Flores-Carapia Rolando , Gonzalez-Ramirez Marlon David , Chimal-Eguia Juan Carlos
Published: May 2022

The proposed algorithm called Image encryption based on chaos, elliptic curve, dynamic S-boxes and variable permutations (IECC) is a symmetric cryptosystem for encrypting bmp images, in this case 512 × 512 pixelfigures are used for testing. This algorithm consists of 15 rounds with a different S-box for each round and each set of S-boxes is different for each image encryption. Based on the above, a permutation is applied beforethe first round, additionally, in round 15 the inverse permutation of the first round intervenes. Both the S-boxes and the permutations are built using the E. Lorenz equations, which obtain solutions with two different points of the elliptic curve chosen randomly in each process. To measure the resistance to differential attack of the proposed cryptosystem, the following measurements are carried out: Number of Pixels Change Rate NPCR, Unified Average Changing Intensity - UACI. Also, taking into account that the generation of the boxes is dynamic, the algebraic attack is avoided; furthermore, with this symmetric cryptosystem it is possible to distribute keys and sign, since an asymmetric system is used in its construction. On the other hand, four types of noise are applied to the encrypted images to evaluate the resistance of the encryption algorithm to this type of attack. Ten instruments are used to measure the quality of encryption; namely: entropy, correlation, discrete Fourier transform, NPCR, UACI, Avalanche Criteria - AC, contrast, energy, homogeneity and a goodness of fit test is proposed using the χ2 distribution
Tetraspanin CD63 reduces the progression and metastasis of head and neck squamous cell carcinoma via KRT1-mediated cell cycle arrest
Authors: Huang Qiang , Shen Yu-Jie , Hsueh Chi-Yao , Zhang Yi-Fan , Guo Yang , Yuan Xiao-Hui , Hu Chun-Yan , Li Jiao-Yu , Tao Lei , Gong Hong-Li , Zhang Ming , Zhou Liang
Published: May 2022

Background: Though metastasis is the leading cause of death in patients with head and neck squamous cell carcinoma (HNSCC), fundamental questions about the mechanisms that enable or inhibit metastasis remain unanswered. CD63, a tetraspanin family member, has been linked to tumor progression and metastasis. However, few studies have examined the role of CD63 in HNSCC. Methods: We discovered CD63 expression in paired HNSCC tissue by tissue microarray. Cell phenotype experiments and lung metastasis mouse model were adopted to investigate the effect of CD63 on tumour metastasis in vitro and vivo. The molecular mechanism was investigated by mass spectrometry, Co-IP, immunofluorescence analysis and molecular docking. Results: CD63 expression was abnormally decreased in HNSCC tissue compared to adjacent tissue, and that this was linked to prognosis. Overexpression of CD63 inhibited the progression and metastasis of HNSCC cells. KRT1 could be a direct interacting partner of CD63. CD63 reduces HNSCC progression via KRT1-mediated cell cycle arrest. Both CD63 and KRT1 expression was significantly decreased in metastatic tissue compared with primary tumor tissue. Conclusions: We reveal a previously unrecognized role of CD63 in HNSCC cells. Our findings contribute to defining an important mechanism of HNSCC progression and metastasis.
Increased Sample Size Proved More Insights for the Population Structure of Mediterranean Loggerhead Sea Turtles
Authors: Kaska Arzu , Koç Gizem , Sözbilen Dogan , Diryaq Salih , Glidan Ashraf , Elsowayeb Abd Alati , Saied Almokhtar , Margaritoulis Dimitris , Theodorou Panagiota , Rees Alan F. , Snape Robin , Broderick Annette , Godley Brendan , Beton Damla , Ozkan Meryem , Jr Imed , Ismail Manel Ben , Hmida Ahmed Ben , Badreddine Ali , Sacdanaku Enerit , Rae Vicky , Abdelwarith Mohamed Said , Naguib Nahla , Nakhla Lobna Ben , Limam Atef , Abderrahim Marwan , Sémelin Julien , Kaska Yakup
Published: May 2022

The loggerhead sea turtle (Caretta caretta), has the broadest distribution among sea turtle species in the Mediterranean and requires regional and international collaborations in addition to local efforts to better inform conservation actions. Molecular techniques are powerful tools to assess population dynamics at large scales, especially by determining the connectivity among different nesting and foraging sites, and genetic diversity. In this study, a large sample was collected synchronously in the nesting areas located in the north, south and east of the Mediterranean. Recently described nesting sites from Albania and other nesting sites represented by lower sample size were also included in order to fully assess the genetic composition of the region’s rookeries. Samples from 710 individuals were collected and the longer (815 bp) mtDNA D-loop fragment of these samples was amplified. We recorded 15 haplotypes, three of which were novel. In addition, our results show that some haplotypes, considered of Atlantic origin, have a wider dispersal in the Mediterranean than previously thought, albeit with low levels of representation. Our results, which also contribute to determining the likely origin of haplotypes that were previously known only from foraging sites, highlight the utility of broad-scale sampling, with increased sample number and longer mtDNA sequence to determine genetic diversity and connectivity. This study also demonstrates that it is important to continue to monitor the contribution of Atlantic origin haplotypes to the Mediterranean population, and the resident Mediterranean population, which is expected to expand its geographical range for reproduction with the effect of climate change and climate change in the long term. This work is important for, among other things, mixed stock analyses (MSA) that seek to localize the origin of stranded or accidentally caught sea turtles or those purposefully obtained from foraging sites to better understand the migratory distribution for conservation purposes.
Long term positional stability of the Argus II Retinal Prosthesis epiretinal implant
Authors: Ghani Nimra , Bansal Jahnvi , Naidu Abhishek , Chaudhary Khurram M.
Published: May 2022

BackgroundThe Argus II Retinal Prosthesis System (Second Sight Medical Products, Sylmar, California) is an epiretinal prosthesis that serves to provide useful vision to people who are affected by retinal degenerative diseases such as retinitis pigmentosa (RP). The purpose of this study was to analyze postoperative movement of the electrode array.MethodsFive patients diagnosed with profound retinal dystrophy who have undergone implantation of retinal prosthesis at Stony Brook University Hospital. Fundoscopy was performed at postoperative month 1 (M1), month 3 (M3), month 6 (M6), month 12 (M12), and month 24 (M24) visits. Fundoscopy was extracted and analyzed via NIH ImageJ. Data analysis was completed using IBM SPSS. Various lengths and angles were measured each postoperative month using ImageJ.ResultsThere was no significant change in distance between the optic disc and the surgical handle (length AB) over the two-year span (F = 0.196, p = 0.705). There was a significant change in distance of length AB overtime between patients between M3 and M6 (p = 0.025). A repeated measures ANOVA revealed that there was statistically significant change of the optic disc-tack-surgical handle angle (𝛾) (M1 to M24) (F = 3.527, p = 0.030). There was no significant change in angle 𝜟 (the angle to the horizontal of the image), angle 𝜶 (tack-optic disc-surgical handle), and angle 𝜷 (optic-disc-surgical handle-tack).ConclusionOur results demonstrate that there may be postoperative movement of the retinal prosthesis over time, as a statistically significant downward rotation is reported over the two years span. It is important, moving forward, to further study this movement and to take into consideration such movement when designing retinal implants.
Evaluation of PASI Before and After Combined Treatment in Mild to Moderate Psoriasis
Authors: Benites Elizabeth , Carrillo Esmeralda , Heras Martha , Moreno Franklin , Cornejo Carlos
Published: May 2022

Background. -
Plaque psoriasis is a disease of immunological origin that damages the skin, mucous membranes. Biological therapies combined with systemic medications are effective in treating plaque psoriasis. Our objective was to evaluate the treatment of Etanercept with methotrexate and to verify its response with the PASI index in its initial and control phase.
Methodology. -
The Universe of patient treated at the Military Hospital in Guayaquil was 2.620 corresponding from January until July 2020; the selected sample according to the inclusion criteria was 94 patients with plaque psoriasis. The method was retrospective, observational, descriptive, cross-sectional, correlational differential analytical.
Result. -
In this study, the prevalence was 3.58%, The BMI index was 28.13 corresponding to overweight and obesity. The PASI index in the initial stage before treatment showed 10.8% and in the control phase, it fell to 2.99%, showing a decrease in lesions and good improvement to the combined treatment. In Student´s T, the combination of Etanercept with Methotrexate was compared with de evolution of PASI index, in the initial and control phases, presenting a value lower than 0.001 < P = 0.05, this response being very significant
Discussion. -
In our study, the combination of Etanercept with Methotrexate has a favorable this disease response in reducing this disease. It´s expected that, in Ecuador, the Health Authorities would implement the Biologics for the treatment of plaque psoriasis and including them in the basic list of medicines of the Public Health Ministry.
A Conceptual Proposal for Ankara's Historical Heritage: Atatürk Forest Farm
Authors: Didem Dizdaroglu
Published: May 2022

Context
Established as green infrastructure for the creation of a systematic agricultural structure for the first time in the history of the Republic, Atatürk Forest Farm (AOÇ) is a cultural heritage. AOÇ has the capacity to become a new food planning and management center as well as an urban open space for citizens and to reconstitute Ankara as a self-sufficient city in the 21st century.
Objectives
This study aims to preserve the AOÇ lands for reevaluating them with an ecological approach in terms of today’s conditions. Regarding the AOÇ’s founding purposes, this study offers a conceptual proposal for reclaiming and reorganizing the Farm.
Methods
The methodology involves literature reviews, examination of AOÇ’s historical development process and planning decisions, site analysis, and development of a conceptual proposal for the designated study area.
Results
Urban agriculture (UA) has the potential to modify existing urban sites into new forms of green spaces offering an alternative land use integrating multiple uses. This study proposes conceptually some opportunities for developing AOÇ, which has the potential to become a productive and ecologically sustainable urban green space with offering various UA benefits.
Conclusions
AOÇ has a significant place and meaning in the collective memory of the Turkish nation and acts as a bridge that carries the past to the future. The farm should be reintroduced to the urban life with new ecological, recreational, and cultural functions by preserving its mission to be an example of a production that fulfills the city’s agricultural and nutritional needs.
Conservation at the edge: connectivity and opportunities from non-protected coral reefs close to a national park in the Colombian Caribbean
Authors: Rodríguez Laura , Acosta Alberto , González-Zapata Fanny L. , Gómez-Corrales Matías , Marrugo Milena , Alvarado-Ch Elvira M. , Dueñas Luisa F. , Andrade Julio , Gutierrez-Cala Lina , Sánchez Juan Armando
Published: May 2022

Confronting a sustained coral reef conservation crisis, we need new opportunities to rethink how to protect areas successfully and efficiently in the face of a changing world. We studied the benthic community, including foraminifera, fish community, and genetic connectivity (SSRs and SNPs) of main reef-building coral, Orbicella faveolata and Agaricia undata coral, along a Non-Protected Area (NPA) reef tract in Barú peninsula, including some isolated banks, near Cartagena and the National Natural Park Corales del Rosario y San Bernando (NNP CRySB), Colombia. The fringing reef track studied is homogeneous in benthic components, including algae, corals, sponges, and foraminifera between all the sites studied. Many reef sites sustain between 42.8% and 53% coral cover, which are among the highest recorded in this region, even higher than values in the nearby NNP. A total of 82 fish species were found, and the Foram Index-FI varies between 2 and 2.5, showing environmental conditions marginal for reef growth. The Barú NPA reef system can be considered spatial refugia under climate change and Anthropocene conditions, including resilient reefs at the mouth of Cartagena Bay (Magdalena River), a place of increased stressing factors. The admixture between NPA and NNP populations, the high coral cover in the NPA, the fish density and composition, the uniqueness of the diapiric banks, and the disturbance resistance are major arguments to protect this reef tract. We suggest designing a co-management scheme to ensure species connectivity, avoid further degradation, and involve different stakeholders.
Observational tests and theoretical developments of hybrid MOND dark matter models
Authors:   , Mistele Tobias
Published: May 2022

The putative effects of dark matter are most easily explained by a collisionless fluid on cosmological scales and by Modified Newtonian Dynamics (MOND) on galactic scales. Hybrid MOND dark matter models combine the successes of dark matter on cosmological scales and those of MOND on galactic scales. An example of such a model is superfluid dark matter (SFDM) which postulates that this differing behavior with scale is caused by a single underlying substance with two phases. In this thesis, I highlight successful observational tests of SFDM regarding strong lensing and the Milky Way rotation curve. I also discuss three problems due to the double role of the aforementioned single underlying substance and show how these may be avoided. Finally, I introduce a novel Cherenkov radiation constraint for hybrid MOND dark matter models. This constraint is different from standard modified gravity Cherenkov radiation constraints because such hybrid models allow even non-relativistic objects like stars to emit Cherenkov radiation.
Anti-inflammatory Activity and Isolation of Luteolin from Plagiochasma appendiculatum Methanol Extract
Authors: Pandey Shweta , Rana Mahendra
Published: May 2022

Plagiochasma appendiculatum, a flavonoid rich liverwort, is reported to be used in the treatment of cuts, burns, outside wounds, bacteriostatic, pulmonary tuberculosis, neurasthenia, fractures, convulsions, scalds, uropathy, and inflammation by tribal communities. In the present study, flavonoid luteolin, reported to possess anti-inflammatory potential, is isolated from P. appendiculatum methanol extract and extract is evaluated for anti-inflammatory effect. Anti-inflammatory potential was studied by protein denaturation assay and carrageenan-induced rat paw edema method. Plant flavonoid is isolated from methanol extract by column chromatography, using petroleum ether and ethyl acetate in various proportion, as mobile phase. Further identified by spectroscopic analysis. In vitro studies, at a concentration of 800 μg/ml, P. appendiculatum methanolic extract (PAME) exhibited 74% inhibition while indomethacin showed 79% inhibition at the same concentration. The extract exhibits a decrease in inflammation in rat hind paw when tested with carrageenan-induced paw edema. PAME at a dose of 150 mg/kg displayed the most potent anti-inflammatory activity compared to the other groups during the course of the observation period. The methanol extract yielded a yellow color crystalline compound which is characterized as 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-chromenone, commonly known as luteolin. Isolation of luteolin from P. appendiculatum is first time reported, which supports the ethnobotanical claims and provides scientific explanation for anti-inflammatory use of mentioned liverwort.
Penyataan Diri Allah di Tengah Kerapuhan Dunia: Pesan Teologis tentang Inkarnasi Allah dalam Tradisi Teologis Yohanes
Authors: Rachmadi Simon
Published: May 2022

Abstract This article describes a theological idea about the presence of God among God’s people. The presence of God takes the form of becoming “flesh” (incarnation), as depicted by the Johannine tradition in the Gospel of John, the First Letter of John, and the Book of Revelation. By becoming “flesh” God wholly participates in the vulnerability and precariousness of the human “flesh”: pointing to the very nature of humanity. This articlelocates the divine incarnation within the daily life of human beings in the “flesh”. Using the method of simple Bible reading, with a limited theoretical approach, this article suggests a hermeneutical message of the Johannine tradition. Since the Word has become “flesh,” the divine realm could always be found in the vulnerability of the world. As a result, despitesuff ering (theodicy) remains a mystery, the experience of vulnerability — through critical, persistent, and grateful faith — is potentially worthy of accommodating the divine presence.

Abstrak Artikel ini mendeskripsikan suatu visi teologis tentang Allah yang setia menyertai umat-Nya. Kesetiaan menyertai umat-Nya itu terwujud dengan cara men-“daging” (berinkarnasi), sebagaimana terlukis di dalam tradisi Rasul Yohanes: yaitu di dalam Injil Yohanes, Surat 1 Yohanes, dan Kitab Wahyu. Cara men-“daging” itu membuat Allah senantiasa terlibat dalam aspek-aspek kerapuhan dan kehinaan kodrati “daging” manusia. Pertanyaannya, di manakah keterlibatan ilahi itu ditemukan di dalam realitas insani sehari-hari yang selalu bersalutkan aneka kerapuhan kodrati? Dengan metode pembacaan Alkitab sederhana,dengan pendekatan teoretis tafsir yang terbatas, artikel ini berusaha mendekati pertanyaan tersebut dengan memeriksa pesan hermeneutis dari tradisi Yohanes. Karena Sang Sabda menjadi “daging”, maka Allah bersemayam di dalam kerapuhan dunia. Akibatnya, meskipun misteri penderitaan (theodicy) tidak akan pernah dapat dijelaskan oleh manusia secara lengkap, pengalaman derita itu — via iman yang kritis, tabah, dan penuh syukur — selalu berpeluang untuk diolah menjadi wadah perjumpaan ilahi.
Assessment of the risks of changes in brachiocephalic vessels according to ultrasound examination of patients with obstructive sleep apnea
Authors: Rubina S. S. , Yusufov A. A. , Makarova I. I. , Tsvetkova N. V. , Larina O. S.
Published: May 2022

Introduction. In the medical literature, there is not enough work on the impact of obstructive sleep apnea (OSA) on the development of atherosclerosis of the brachiocephalic arteries and venous dysgemenia. For the purpose of early diagnosis of vascular complications, further study of extracranial vessels in patients with OSA is necessary.

Aim. To study the chances of changes in brachiocephalic vessels by ultrasound examination in patients with obstructive sleep apnea.

Materials and methods. A survey was carried out of 88 patients. The results of anthropompetry, polysomnography and ultrasound examination of brachiocephalic vessels were evaluated.

Results and discussion. New data were obtained on the severity of macroangiopathy, an increase in the peak systolic blood flow velocity in the internal jugular veins, and an increase in the diameters of the vertebral veins in patients with sleep apnea. It was also found that in patients with OSA, the chances of having a wide diameter of the common carotid artery (CCA) on both sides and the internal carotid artery on the left are more than 3 times higher, the probability of thickening of the intima-media complex in the area of the CCA and its bifurcation is more than on the left 3.5 times and the chances of macroangiopathy are 3 times higher in comparison with the examined patients without apnea.

Conclusion. Timely assessment of the entire spectrum of pathological changes in the brachiocephalic vessels in patients with OSA will make it possible to diagnose early signs of atherosclerotic lesions of the arteries, venous dysfunction at the extracranial level.
Endolymphatic sac tumor: rewiev of literature
Authors: Diab Kh.M.A. , Daikhes N. A. , Saydulaev V. А. , Yunusov A. S. , Pashinina O. A. , Mikhalevich A. E. , Panina O. S.
Published: May 2022

Endolymphatic sac tumors are rare neoplasms of the temporal bone, histologically benign, but clinically behaves as malignant tumors causing destruction of surrounding tissues. The tumor originates from the posterior surface of petrous part of temporal bone, where endolymphatic sac is situated anatomically. The tumor causes destruction of the posterior surface of the petrous part of the temporal bone, inner ear, mastoid process, etc. Endolymphatic sac tumor can be both sporadically and in patients with von Hippel – Lindau disease. Due to the rarity of this tumor, it is easy to confuse it with other tumors, such as paraganglioma, middle ear adenoma, adenocarcinoma, papillary thyroid carcinoma or papilloma of the vascular plexus. Computed tomography (CT) and magnetic resonance imaging (MRI) are of great diagnostic importance and play an important role in planning treatment tactics. The optimal method of treatment is resection of pathologically altered tissues. In some cases (incomplete resection of tumor, the patients with concomitant diseases or inoperable cases) receive courses of X-ray or radiosurgery. If a tumor is detected in the early stages, the volume of resection can be minimized while preserving hearing and vestibular function of the inner ear. Recurrence usually happens due to difficulty to identify the extension of the tumor. Diagnosis and correct preoperative planning, with embolization if it possible, will facilitate surgery and avoid subtotal tumor resection due to intraoperative bleeding. Long follow-up period is important in order to avoid recurrences. Insufficient coverage of this problem in the literature is associated with a low percentage of its occurrence in otosurgical practice, which complicates the timely diagnosis and treatment of this type of tumors of the temporal bone, worsens the prognosis.