bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrating reliability analysis into MBSE for FPGA-based safety critical I&C system design in nuclear power plants
Authors: Wang Fanyu , Zhao Yang , He Jinyu , Chen Qi , Lei Minjie , Zhao Yang , Wang Heng
Published: July 2024

With the widespread application of Field Programmable Gate Array (FPGA) technology in the instrumentation and control (I&C) systems of nuclear power plants (NPPs), its design reliability has become the key to ensuring the subsequent safe operation of NPPs. However, the traditional document-based design method is no longer sufficient to meet the current design needs of complex systems, and there is a lack of research related to the reliability and security analysis of FPGA-based systems. Therefore, the overall goal of this study is to integrate reliability analysis into the model-based systems engineering (MBSE)-based design of FPGA-based I&C systems. Based on the typical application characteristics of the FPGA, a digital design framework for FPGA-based systems is proposed to realize a traceable design process from requirements to implementation. Subsequently, a model-based forward comprehensive reliability analysis method is proposed, which uses a SysML-based mapping mechanism to integrate Failure Mode and Effects Analysis (FMEA) and Fault Tree Analysis (FTA) methods into the design process, so as to comprehensively identify and analyze failure modes from systems to components and optimize and improve system design. Finally, the proposed method is applied to the analog output design of FPGA-based systems. The proposed method can provide guidance for improving the reliability of FPGA-based DI&C systems and provide theoretical basis for the further engineering application.
Caveolin-3 regulates slow oxidative myofiber formation in female mice
Authors: Zhang Xinyuan , Shi Xiaoyang , Li Jinjie , Kou Guangning
Published: July 2024

Objectives

Caveolin-3 (Cav-3) plays a pivotal role in maintaining skeletal muscle mass and function. Mutations or deletions of Cav-3 can result in the development of various forms of myopathy, which affect the integrity and repair capacity of muscle fiber membranes. However, the potential effect of Cav-3 on myofiber type composition remains unclear.

Methods

To investigate the effect of Cav-3 on muscle strength and running capacity, we examined the grip force test and the low/high-speed running test. Oxidative and glycolytic myofiber-related genes, proteins, and skeletal muscle fiber composition were measured to determine the role of the Cav-3 in oxidative myofiber formation.

Results

We report the impact of Cav-3 on enhancing muscle endurance performance in female mice, and the discovery of a new physiological function to increase the proportion of slow-twitch oxidative muscle fiber by analyzing the gastrocnemius and soleus. Skeletal muscle-specific ablation of Cav-3 in female mice increased oxidative myofiber-related gene expression and type I oxidative myofiber composition, with resultant improvements in endurance performance. In male mice, the absence of Cav-3 in skeletal muscle reduced in the expression of glycolytic fiber-related genes and proteins.

Conclusions

This study identified Cav-3 as a regulator of slow-twitch oxidative muscle fiber formation acting on female mice, which may provide a potential target for improving muscle oxidative function.
Hydrothermally synthesized transition metal doped ZnO nanorods for dye degradation and antibacterial activity
Authors: Sarbudeen Sulthana Sabura , Sinnappan Jesurani , Arulanandam Jegatha Christy
Published: July 2024

In this study, Ni-doped ZnO (NZ) and Ni–Mn dual-doped ZnO (NMZ) NPs were synthesized by hydrothermal method. Various analytical techniques, such as XRD, UV–vis, FTIR, PL, SEM, EDAX, and HR-TEM, were employed to investigate the effect of doping transition metal ions in the ZnO lattice. The powder X-ray diffraction (XRD) patterns confirmed a hexagonal structure with average crystallite sizes of 30.66 nm and 27.09 nm for NZ and NMZ nanoparticles, respectively. Tauc’s plot showed that the energy bandgap was redshifted to 2.9 from 2.8 eV by doping transition metal ions in ZnO. The photoluminescence spectrum displayed various peaks, indicating the emission behaviour of the nanomaterials. The photocatalytic performance of the catalysts was tested under visible light sources against Crystal Violet (CV) dye. The degradation efficiency, for NMZ achieved a maximum degradation efficiency of 91.1 %. Antibacterial activity was evaluated against gram-positive (B. subtilis and S. aureus) and gram-negative (E. coli and P. aeruginosa) bacteria. The NMZ exhibited higher photocatalytic and antibacterial activity than NZ.
Job satisfaction of managers of small business units in the perspective of remote work - pilot research
Authors:   Uniwersytet Łódzki, Lubrańska Anna , Musialik Paulina ,   Przedszkole Miejskie nr 155, Łódź
Published: July 2024

This study is devoted to the issue of the professional functioning of managers of small business units, whose work mode has changed from stationary to remote, requiring them to adapt their companies to manage their teams in new conditions and on new principles. In the context of this change, the job satisfaction of the surveyed managers (n = 42) was assessed, using Anna Zalewska's Job Satisfaction Scale. The results showed a high level of job satisfaction among 54.8% of respondents (only 9.5% of respondents had a low level of the variable), with the variables describing managerial responsibilities not significantly impacting the level of job satisfaction. The presented research reveals an application dimension for organisational practice.
Success factors for the development of FinTech entities on the Polish market: a case study
Authors:   Uniwersytet Mikołaja Kopernika w Toruniu, Czarkowska Marta , Polasik Michał ,   Uniwersytet Mikołaja Kopernika w Toruniu
Published: July 2024

The dynamic development of services in the financial market that use digital technologies has made FinTech synonymous with modernity, and a term with growing popularity, both among banking professionals and the wider consumer community. Since 2009, the dynamic development of this new segment of non-banking startup entities within the financial sector, FinTechs, has been observed. The main objective of this study is to identify success factors for the development of FinTech entities, by conduscting research using a multiple case study method involving six selected FinTech entities operating in the Polish market, supported by an extensive literature review. Our research, as well as the analysis of secondary sources, established that one of the key factors supporting the success of the development of FinTech entities is the establishment of cooperation with banks, which brings significant benefits to both parties - banks and FinTechs - allowing them to exploit the potential for complementarities between their strengths and increase opportunities for joint development. Some of the solutions introduced by FinTechs are fully based on cooperation with banks, for example BLIK, a system integrated with mobile banking applications. The main barrier to the development of FinTechs in Poland has turned out to be limitations related to legal regulations and the manner of their implementation in the Polish market. The financial market is becoming increasingly regulated, and, at the same time, the Polish financial market supervisory authority is pursuing a rather restrictive policy. The most important factor that determines the popularity of digital FinTech services among Polish consumers is the ability to provide them with broadly understood convenience.
Single-Trial Representations of Decision-Related Variables by Decomposed Frontal Corticostriatal Ensemble Activity
Authors: Handa Takashi , Fukai Tomoki , Kurikawa Tomoki
Published: July 2024

The frontal cortex-striatum circuit plays a pivotal role in adaptive goal-directed behaviors. However, it remains unclear how decision-related signals are mediated through cross-regional transmission between the medial frontal cortex and the striatum by neuronal ensembles in making decision based on outcomes of past action. Here, we analyzed neuronal ensemble activity obtained through simultaneous multiunit recordings in the secondary motor cortex (M2) and dorsal striatum (DS) in rats performing an outcome-based left-or-right choice task. By adopting tensor component analysis (TCA), a single-trial–based unsupervised dimensionality reduction approach, for concatenated ensembles of M2 and DS neurons, we identified distinct three spatiotemporal neural dynamics (TCA components) at the single-trial level specific to task-relevant variables. Choice-position–selective neural dynamics reflected the positions chosen and was correlated with the trial-to-trial fluctuation of behavioral variables. Intriguingly, choice-pattern–selective neural dynamics distinguished whether the incoming choice was a repetition or a switch from the previous choice before a response choice. Other neural dynamics was selective to outcome and increased within-trial activity following response. Our results demonstrate how the concatenated ensembles of M2 and DS process distinct features of decision-related signals at various points in time. Thereby, the M2 and DS collaboratively monitor action outcomes and determine the subsequent choice, whether to repeat or switch, for action selection.
Gamma Responses to Colored Natural Stimuli Can Be Predicted from Local Low-Level Stimulus Features
Authors: Kanth Sidrat Tasawoor , Ray Supratim
Published: July 2024

The role of gamma rhythm (30–80 Hz) in visual processing is debated; stimuli like gratings and hue patches generate strong gamma, but many natural images do not. Could image gamma responses be predicted by approximating images as gratings or hue patches? Surprisingly, this question remains unanswered, since the joint dependence of gamma on multiple features is poorly understood. We recorded local field potentials and electrocorticogram from two female monkeys while presenting natural images and parametric stimuli varying along several feature dimensions. Gamma responses to different grating/hue features were separable, allowing for a multiplicative model based on individual features. By fitting a hue patch to the image around the receptive field, this simple model could predict gamma responses to chromatic images across scales with reasonably high accuracy. Our results provide a simple “baseline” model to predict gamma from local image properties, against which more complex models of natural vision can be tested.
Chinese Verbal Fluency Deficiency in Temporal Lobe Epilepsy with and without Hippocampal Sclerosis: A Multiscale Study
Authors: Wang Kangrun , Xie Fangfang , Liu Chaorong , Wang Ge , Zhang Min , He Jialinzi , Tan Langzi , Tang Haiyun , Xiao Bo , Wan Lily , Long Lili
Published: July 2024

To test a Chinese character version of the phonemic verbal fluency task in patients with temporal lobe epilepsy (TLE) and assess the verbal fluency deficiency pattern in TLE with and without hippocampal sclerosis, a cross-sectional study was conducted including 30 patients with TLE and hippocampal sclerosis (TLE-HS), 28 patients with TLE and without hippocampal sclerosis (TLE-NHS), and 29 demographically matched healthy controls (HC). Both sexes were enrolled. Participants finished a Chinese character verbal fluency (VFC) task during functional MRI. The activation/deactivation maps, functional connectivity, degree centrality, and community features of the left frontal and temporal regions were compared. A neural network classification model was applied to differentiate TLE-HS and TLE-NHS using functional statistics. The VFC scores were correlated with semantic fluency in HC while correlated with phonemic fluency in TLE-NHS. Activation and deactivation deficiency was observed in TLE-HS and TLE-NHS (p < 0.001,k ≥ 10). Functional connectivity, degree centrality, and community features of anterior inferior temporal gyri were impaired in TLE-HS and retained or even enhanced in TLE-NHS (p < 0.05, FDR-corrected). The functional connectivity was correlated with phonemic fluency (p < 0.05, FDR-corrected). The neural network classification reached an area under the curve of 0.90 in diagnosing hippocampal sclerosis. The VFC task is a Chinese phonemic verbal fluency task suitable for clinical application in TLE. During the VFC task, functional connectivity of phonemic circuits was impaired in TLE-HS and was enhanced in TLE-NHS, representing a compensative phonemic searching strategy applied by patients with TLE-NHS.
Parent eHealth Preferences: Perceived Credibility and Personal Reactions to AbilitiCBT, BEAM, and Triple P Online
Authors: Rioux Charlie , Konkin Avaline , Tomfohr-Madsen Lianne , MacKinnon Anna L. , Cameron Emily E. , Watts Dana , Xie E. Bailin , Roos Leslie E.
Published: July 2024

Parental eHealth needs and preferences are unknown. Evidence from in-person programs shows that programs that prioritize parent preferences have higher enrollment and adherence. Better knowledge of parental impressions and preferences based on current eHealth programs could help identify programs that are most in line with parental values, goals, and needs. Accordingly, the present study aimed to compare parental perceptions and preferences based on textual descriptions of three eHealth programs that have been prescribed to parents: AbilitiCBT (mental health-focused), BEAM (mental health and parenting-focused), and Triple P Online (parenting-focused). 177 parents of 0-5-year-old children in the United States were recruited through MTurk. Mental health symptoms in this sample were high (70.1% clinically concerning depression and/or anxiety symptoms and 74.6% clinically concerning parenting stress symptoms). Results showed that Triple P was less likely to be chosen than AbilitiCBT or BEAM; AbilitiCBT seemed more helpful to participants. There was considerable variability, and all programs were preferred by at least 17% of parents. Overall, the present study suggests that parents experiencing high psychological distress are less likely to choose to participate in a parenting program without mental health support and that it is important to offer diverse psychosocial service options to meet the needs of more parents. Further research is needed to identify specific program characteristics that parents prefer as well as parents’ rationale for their choices, which would help better tailor interventions to their preferences.
Só uma cantada? Análise da percepção do assédio de rua a partir do sexismo ambivalente
Authors: Fernandes Teixeira Alves Natália , Cunha de Souza Luana
Published: July 2024

Este estudo objetivou analisar a percepção do assédio de rua no contexto brasileiro. Participaram 323 pessoas da população geral, com idades variando entre 18 e 65 anos (M=27,5; DP=8,10), as quais responderam a um questionário online com situações fictícias de assédio de rua, medidas de percepção do assédio, uma questão aberta e perguntas sociodemográficas. Os resultados quantitativos mostraram que os participantes percebem o assédio como um comportamento sexista; contudo, mulheres percebem mais do que homens. Essa percepção varia de acordo com o contexto em que o assédio ocorre, ou seja, o assédio que acontece na rua é visto como mais sexista do que quando ocorre em uma festa. Ademais, os resultados mostram que o sexismo hostil influencia significativamente de forma negativa a percepção do assédio de rua. Além disso, os resultados qualitativos convergem com o que foi encontrado nos dados quantitativos, de modo que as pessoas percebem e justificam a situação ocorrida como assédio.
A beetroot-based beverage produced by adding Lacticaseibacillus paracasei: an optimization study
Authors: Durukan Gamze , Sari Ferda , Karaoglan Hatice Aybuke
Published: July 2024

The present study aimed to optimize the production conditions of a beetroot-based beverage using Lacticaseibacillus paracasei. The experiment was meticulously planned and executed using the Box–Behnken design in Response Surface Methodology (RSM), which provided 17 different combinations. The independent variables in this study included the heat treatment temperature (60–80℃, the heat treatment time (10–30 s), and the incubation temperature (24–36℃). The variables evaluated in this study included pH, total acidity (TA), total phenolic content (TPC), total betalain content (TBC), yellow color (OD420), general acceptance (GA), and total count of lactic acid bacteria (LAB). The samples were determined to have TPC ranging from 67.90 to 437.15 mg GA/L and TBC ranging from 147.52 to 747.21 mg/L. The samples subjected to incubation temperatures of 30℃ and 36℃ were typically favored by the panelists and exhibited better results in terms of chemical analysis compared to the samples incubated at 24℃. According to RSM, heat treatment at 60℃ for 22 min and an incubation temperature of 31℃ were the optimum production conditions. Under these optimal conditions, RBJ has maximum TBC, total LAB, and GA scores, indicating nutrient-dense and appealing to consumers.
Dinámica interna de familias: afrontamientos tras el proceso migratorio
Authors: Duque Gómez Darlin , Noreña Aristizábal Melissa , Herrera Rivera Ovidio
Published: July 2024

El objetivo del artículo es analizar estudios nacionales e internacionales que identifican experiencias de familias migrantes, afectaciones y afrontamientos en su dinámica interna. La metodología es de corte cualitativa, mediada por procesos hermenéuticos, al cual se vinculó el análisis de fuentes primarias de información en bases de datos indexadas y repositorios institucionales, además de incluir personas y familias afectadas por el fenómeno migratorio. Los resultados identifican problemáticas del país subyacentes de esta problemática, entre ellas: económicas, sociales y políticas con afectación a la dinámica interna familiar, al respecto, factores protectores como la unidad familiar, el apoyo económico, los procesos comunicativos, mediados por las nuevas tecnologías, el tiempo en familia, la construcción de vínculos y afecto desde la distancia, se articulan como estrategias de afrontamiento que ayudan a regular la funcionalidad y el bienestar de las familias, aspecto particular en la mayoría de personas migrantes, construido en escenarios de incertidumbre, crisis y tensión, que pese a los riesgos representan posibles salidas frente a los avatares de la vida, al respecto cada familia acorde a su contexto y posibilidades vitales provee estrategias y afrontamientos para alcanzar este interés. El artículo, resulta novedoso y aportante en el contexto de las ciencias sociales, indagando en el análisis de los problemas migratorios con afectaciones estructurales en personas y familias, especialmente en su dinámica interna. El estudio genera aportes significativos en los procesos de intervención y acompañamiento psicosocial, además de proveer un contexto de análisis y reflexión alineado a las políticas migratorias colombianas e internacionales en el tema familiar.
Time-Varying Role of House Prices on Monetary Policy in Türkiye
Authors: Gayaker Savaş , Güney Ahmet
Published: July 2024

The main focus of this study is examining the time-varying effects of house prices on monetary policy in Türkiye from February 2010 to November 2021. We analyse these effects using a time-varying parameter vector autoregressive model with stochastic volatility (TVP VAR-SV). The evidence indicates that responses of inflation to positive house price shocks decrease over time. The response of credit and interest rates to positive house price shocks increases after 2018. The results reveal that the responses of the Central Bank of the Republic of Türkiye (CBRT) to the changes in the housing market have changed over time.
Investigating the Effect of Digitalization in Financial Inclusion on the Financial Performance of Deposit Banks in Türkiye
Authors: Yılmaz Cihan , Yıldırım Hakan
Published: July 2024

This study investigates the impact of digitalisation in financial inclusion on the financial performance of deposit banks operating in Türkiye between 2010 and 2021. The study's dependent variables are the financial performance indicators, namely the return on assets (ROA) and return on equity (ROE). The number of ATMs and data related to Internet banking are explanatory variables, while asset size, equity ratio, and economic growth are control variables. The analyses conducted using the Two-Step System GMM method reveal that the lagged values of profitability indicators, the number of internet banking customers, financial transactions made through internet banking, equity ratio, asset size, and economic growth have a positive effect on profitability, while the number of ATMs has a negative impact.
Ekonomik Risk, Ekonomik Özgürlük İndeksi, Yolsuzluk Algısı İndeksi ve İnsani Gelişim İndeksi’nin Mekânsal Analizi
Authors: Kalkan Yusuf
Published: July 2024

Bu çalışmanın amacı 163 ülkenin ekonomik risk (ER), ekonomik özgürlük indeksi (EÖİ), yolsuzluk algısı indeksi (YAİ) ve insani gelişim indeksi (İGİ) açısından mekânsal (komşuluk) ilişkilerini incelemektir. Mekânsal analiz için Moran I, Coğrafi Ağırlıklı Regresyon (GWR) ve Çok Ölçekli Coğrafi Ağırlıklı Regresyon (MGWR) yöntemleri kullanılmıştır. MGWR modelleri, dünya genelinde ülkelerin komşu ülkeleriyle ER, EÖİ ve YAİ açısından güçlü mekânsal ilişkilere sahip olduğunu fakat İGİ açısından anlamlı olmadığını göstermiştir. Bu sonuç ER, EÖİ ve YAİ göstergelerinin daha çok ülke ekonomisiyle ilgili olması ve günümüzde ülkelerin ekonomik yönden birbirine bağımlı hale gelmesiyle açıklanabilir. İGİ ise insan yaşam kalitesine odaklanması ve ülkeler arasındaki sosyal-kültürel farklılıkların varlığı anlamlı mekânsal ilişkilerin olmamasına sebep olabilir.
Makro İhtiyati Politikaların Küresel Finansal Kriz Sonrası Türk Bankacılık Sektörü Kredi Riskine Etkileri
Authors: Mahmutoğlu Murat
Published: July 2024

Finansal istikrarın sağlanmasında önemli bir role sahip olan makro ihtiyati politikalar, 2008 küresel finans krizi sonrasında Türkiye’de yoğun şekilde uygulama alanı bulmuştur. COVİD-19 salgını süresince Bankacılık Düzenleme ve Denetleme Kurumu’nun aldığı kararlar sonucunda bankaların donuk alacaklarının toplam krediler içindeki payı gerilemiş ve yakın izlemedeki krediler, sektörün kredi riskini daha iyi ifade etmeye başlamıştır. Çalışmanın amacı, Türkiye’de 2008 yılı sonrasında finansal istikrarı sağlama amaçlı uygulanan makro ihtiyati politikaların Türk bankacılık sektörü kredi riskine etkilerini analiz etmektir. Genelleştirilmiş Momentler Yöntemi tahmincileri ile gerçekleştirilen dinamik panel veri modeli tahmin sonuçlarına göre oluşturulan sıkılaştırıcı ve genişletici makro ihtiyati endekslerin bankaların kredi verme eğilimine etkisi istatistiki olarak anlamsız çıkmıştır. Bununla birlikte, makro ihtiyati politika endeksteki yükseliş, bankaların kredi riskini istatistiki olarak da anlamlı bir biçimde düşürmektedir. Yani uygulanan makro ihtiyati politikalar kredi riskini olumlu etkilemektedir. Uluslararası akademik çalışmaların bulgularına göre gelişmiş batı ülkelerinde makro ihtiyati politikaların bankaların kredi verme eğilimine ve risklilik seviyesine etkisi güçlü iken, Türkiye’de etkisi görece zayıf çıkmıştır.
Sağlık Hizmetlerinde Mantar Yönetim Yaklaşımı, Kolektif Etkinlik ve Rekabetin Performansa Etkisi
Authors: Ayhan Emine , Güvener Hakan
Published: July 2024

Bu çalışmanın amacı, sağlık hizmetlerinde mantar yönetim yaklaşımının ekip performansına etkisini tespit etmek ve bu etkileşimde kolektif etkinliğin aracılık rolü ile rekabetin düzenleyici rolünü araştırmaktır. Bu kapsamda çalışmada; Gaziantep’te faaliyet gösteren kamu ve özel sağlık kuruluşlarından kolayda örneklem yöntemiyle anket tekniği kullanılarak 449 sağlık çalışanından veriler elde edilmiştir. Verilerin analizi için yapısal eşitlik modeli (YEM) kullanılmıştır. Yapılan analizler sonucunda; sağlık kuruluşlarında mantar yönetim yaklaşımının ekip performansını pozitif yönde etkilediği ve bu etkileşimde kolektif etkinliğin aracılık rolü olduğu, rekabetin ise düzenleyici etkisinin olduğu görülmüştür.
Türkiye’de Vergi Yükü Ölçümü: Yapısal Eşitlik Modeli Analizi
Authors: Püren Serap , Yücedoğru Recep
Published: July 2024

Türkiye’de bireyler, genellikle vergi yükünün yüksekliğinden şikâyet ederler. Çalışma, matematiksel olarak ölçülebilen objektif vergi yükü ve literatürde ölçülmesinin oldukça zor olduğu ifade edilen subjektif vergi yükünü ölçmeyi amaçlamıştır. Bu amaç doğrultusunda Yapısal Eşitlik Modelinden yararlanılan çalışmada, objektif vergi yükü üzerinde; gelir düzeyi ve ödenecek verginin, subjektif vergi yükü üzerinde ise vergi adaleti, vergi karmaşıklığı, hükümete güven ve vatandaşlık bilincinin etkili olduğu sonucuna varılmıştır. Çalışma, subjektif vergi yükünün (%58) objektif vergi yükünden (%25, %33) yüksek olduğunu ortaya koyması bakımından literatürdeki çalışmalardan ayrılmaktadır. Bu bağlamda çalışma, literatüre özgün ve önemli katkılar sunmaktadır.
İhracatta Ürün Çeşitliliği ve Ekonomik Büyüme: Geçiş Ekonomileri Üzerine Panel Veri Analizleri
Authors: Abutalipov Murat , Değer Mustafa Kemal
Published: July 2024

Bu çalışmanın amacı, geçiş ekonomilerinde ihracat çeşitliliği ve ekonomik büyüme ilişkilerini araştırmaktır. Bu amaç doğrultusunda 1995-2020 yılları dikkate alınarak Westerlund eşbütünleşme testleri, Pesaran CCE testleri ve Emirmahmutoğlu-Köse nedensellik testleri kullanılmıştır. Ayrıca çalışmada geçiş ekonomileri gruplara ayrılarak ampirik sonuçlar hem ülke grupları hem ülke bazında ayrı ayrı incelenmiştir. Bulgular, Avrupa Birliğine üye geçiş ekonomilerinde ihracatta ürün çeşitliliğinden ekonomik büyümeye doğru tek yönlü nedensellik ilişkisi tespit edilmişken, diğer geçiş ekonomilerinde değişkenler arasında herhangi bir anlamlı ilişki bulunmamıştır.
Türkiye ve Dünya Gıda Fiyatları İlişkisi: Dinamik Korelasyon ve Dinamik Regresyon Analizi
Authors: Kaya Muhammed Veysel , Yıldız Ertuğrul Şeyda
Published: July 2024

Çalışmada Türkiye gıda fiyatları ve dünya gıda fiyatları ilişkisi 2005.1-2023.3 dönemini kapsayan aylık veriler kullanılarak analiz edilmiştir. Çalışmada önce serilerin doğrusallıkları analiz edilmiş ve serilerin doğrusal olmayan özellik taşıdıkları ortaya konulduktan sonra doğrusal olmayan zaman serisi modelleri ile uygulamalı çalışma tamamlanmıştır. Uygulamalı analizde önce Türkiye ve dünya gıda fiyatları arasındaki dinamik korelasyon ilişkisi DCC-GARCH yöntemi kullanılarak incelenmiş ardından dinamik regresyon analizi için MSR ve Kalman filtresi modelleri kullanılmıştır.
Identifying the Peculiarities of Students’ Aggressive Behaviour in Physical Education Lessons
Authors: Sniras Sarunas
Published: July 2024

Background. Recently, a lot of special attention has been paid to the school environment where students’ aggressive behaviour that spreads quickly is getting more expressed and reflects processes in the modern society and their consequences for the young generation. It can often have various short- and long-term consequences for a student’s behaviour, communication with others, emotional state or his/her self-esteem. Thus, this complex situation encourages to get interested in understanding the underlying causes of students’ aggressive behaviour and peculiarities of its frequent manifestation.
Objectives. The study aimed to reveal the peculiarities of students’ aggressive behaviour expression in physical education lessons in the context of age and gender aspects.
Material and methods. A total of 197 students participated in the study, comprising 52 girls aged 12-13 years, 44 boys of the same age group, 60 girls aged 14-15 years and 41 boys of the same age.
Results. The findings of the study indicated that 14-15-year-old students were more prone to the following forms of aggressive behaviour in physical education lessons: negativism, offence, irritation, physical and verbal aggression compared with 12-13-year-old students. It was also determined that older students demonstrated statistically significant higher levels of hostility and aggressiveness than younger counterparts.  When analysing the students’ aggressive behaviour in the aspect of gender, it was found that boys often expressed the following forms of aggressive behaviour: negativism, offence, irritation and physical aggression; meanwhile, girls were more prone to the feeling guilty and verbal aggression. Higher hostility is more characteristic to boys than to girls, but the aggressiveness observed in the groups of boys and girls was assessed similarly according to the aggressiveness index.
Conclusions. The results obtained could be subjected to further analysis in order to enhance their effectiveness, for example, by examining concrete life situations of students.
The Nature of the Physics of Matter with Negative Mass
Authors: BG Golovkin
Published: July 2024

The formation of a substance with negative mass (negamatter) at very high temperatures or body speeds above 235696.8871 km/s is theoretically justified. The reason for this is the reversal of the direction of time inside the substance. The law of dependence of body weight on the rate of time passing in the physical body has been derived. Based on the weakness of gravitational forces, the stability of negamatter is justified, under appropriate conditions.
The Revised Trauma Score: A Better Early Predictor for Survival of Head Trauma Patients than the Glasgow Coma Scale-Age-Pressure Score
Authors: Patel Richa , Ghag Geeta Sandeep , Iyer Sandhya , Nandu Vipul Versi
Published: July 2024

Purpose: Trauma is a common cause of death worldwide and head injury is the most common form of trauma presented at the Emergency Department. Physiological scores are better for predicting outcome than anatomical scores. To reduce mortality rates, this study compared the capacity of the revised trauma scores (RTS) and the Glasgow coma scale- age- pressure (GAP) scores to predict the survival of patients and effectively channel resources.Methods: An observational study of head trauma patients aged 12 to 80 years was performed at a tertiary care center (N = 500). We noted demographic information, RTS and GAP trauma scores, and outcomes in terms of mortality or survival at 24 hours, 48 hours, and 7 days.Results: Of the 500 patients who were enrolled, 414 (82.8%) survived 24 hours, 373 (74.6%) survived 48 hours, and 265 (53%) survived after 7 days. Using the Receiver Operating Characteristic curve, the RTS score was a significantly better predictor of survival in patients with head trauma than the GAP score at 24 hours (p = 0.044) and 48 hours (p = 0.049) of admission. The results were not significantly different at 7 days (p = 0.240). Mortality or survival outcomes were not significantly different between the RTS and GAP scores (p = 0.373).Conclusion: RTS appears to be a better early predictor for mortality (within 48 hours of admission) than the GAP score. The RTS was more effective in directing the triage of patients which improved survival rates in head trauma patients.
The Association of Isolated Cecal Necrosis Symptoms with Acute Appendicitis: A Case Report
Authors: Cyrielle Signe , Harold Esseme Camille , Maï-Pamela Mekieje Tumchou , Stéphane Kohpe Kapseu , Souleymane Ouedraogo
Published: July 2024

We report a case of isolated cecal necrosis (ICN) associated with acute appendicitis in a geriatric patient in order to underline the didactic, diagnostic and therapeutic interest. This was a 70-year-old widowed female farmer living in a rural area who presented with localized abdominal pain in the right iliac fossa. The diagnosis of acute appendicitis was made. A Mac Burney incision approach revealed ICN and an inflamed appendix. The patient had an ileostomy and a partial cecal necrosectomy with an epiploic patch. A digestive fistula occurred on postoperative Day 60. The patient was transferred to a more technical center where she had a right hemicolectomy with latero-lateral ileocolic anastomosis. The prognosis was poor. The patient died 4 days later in respiratory distress.
Application of an Automatic Suction Device to a Patient with A Tracheostomy Tube in the General Ward: A Case Report
Authors: Yu Sehyeon , Lee Hanyoung , Lee Jae-Myeong
Published: July 2024

The A-1000 (Elmeca, Co. Ltd., Seoul, Korea) electrical automatic airway suction device, was designed to operate as a customizable repeated closed suction device. It can be used for patients with intubation or tracheostomy tubes. This is the first recorded case of the use of the A-1000 in a general ward patient with a tracheostomy tube. A 91-year-old man presented having attempted suicide by hanging and was admitted to this institution. Although extubation was performed in the intensive care unit, the patient required 2 reintubations. The tracheostomy was performed, and the A-1000 was applied. After weaning from mechanical ventilation, the patient was transferred to the General Ward with a tracheostomy tube in place for effective removal of sputum by the A-1000. The tracheostomy tube was successfully removed, and the patient was discharged. The effectiveness and safety of the A-1000 needs further study by expanding the applications of this device.
Singleplex Assay for Fitness Measurements v1
Authors: Ross David
Published: July 2024

This protocol outlines an assay for the singleplex measurement the fitness of plasmid variants in E.coli. This protocol is used during onboarding of a new protein function for the Pooled, Growth-Based Assay. In this protocol, clonal bacterial stocks are measured instead of a pooled mixture, and the end-point OD measured after each growth cycle is used as a proxy for the DNA barcode count data that is produced by the Pooled, Growth-Based Assay. The fitness estimates from the end-point OD measurements are used to fine-tune the plasmid circuit and the assay conditions in advance of running the Pooled, Growth-Based Assay. The inputs include separate E. coli glycerol stocks for each variant. The protocol begins with several growths which convert the separate glycerol stocks into cultures that have reach stationary phase in a 96-well plate. The glycerol stocks are first grown overnight in separate tubes. The next morning, the optical density (OD) of each culture is measured, and then each culture is distributed into a 96-well growth plate. This plate is placed in a plate reader/incubator to grow to stationary phase (~12 hours) without antibiotics or additives (except those required for plasmid maintenance), with optical density (OD) and fluorescent measurements being taken every 5 minutes and at the end of each growth plate's incubation. After this point, the cultures are ready to act as a inputs for subsequent growth cycles. The four subsequent growth cycles (i.e., timepoints 1-4) are all ~3 hours long, so that cells stay in mid-log phase. Small amount of the plated cultures at the end of each cycle acting as input for the subsequent growth cycle. The OD measured at the end of each growth cycle (i.e., the end-point OD) will be used in the downstream fitness calculation. Contents of each growth plate for timepoints 1-4 (growth plates 2-5): Timepoint 1: This growth plate contains additives to initiate gene expression, but no selection antibiotic. Timepoint 2: This growth plate contains additives to initiate gene expression and the selection antibiotic. Timepoint 3: This growth plate contains additives to initiate gene expression and the selection antibiotic. Timepoint 4: This growth plate contains additives to initiate gene expression and the selection antibiotic.
Gender, Intraparty Competition, and the Substantive Focus of Parliamentary Questions in South Africa
Authors: Espírito-Santo Ana , Sanches Edalina Rodrigues , Kartalis Yani
Published: July 2024

Extant research suggests that women ask more parliamentary questions (PQs) on soft policy domains while their male peers focus on hard domains, which are arguably more relevant. This study contributes to this body of research by examining how electoral incentives shape intraparty politics, and specifically the substantive focus of PQs. It argues that women’s focus on soft policy domains is not constant, with variations found in situations where intraparty competition is high. Female MPs will have fewer incentives to focus on soft policy domains if they are electorally vulnerable and as elections draw closer. The mechanism is clear: Women face strong bias in parliament, which means they need to work harder to stand on an equal footing with their male counterparts. As a result, rather than shying away from competition, they will try to maximize their career prospects by shifting their attention to (hard) policy domains that are considered more important to both parties and voters. These claims are tested in the case of South Africa, drawing upon a novel dataset of PQs from 2006 to 2023. South Africa is an interesting case study as it is one of the most feminized parliaments in Africa and has strong electoral incentives for intraparty competition. The findings confirm most theoretical expectations and clarify the electoral and gender-related predispositions that drive the substantive focus of questions.
The effects of organic and inorganic lithium salts assessed in rat primary generalized seizure model
Authors: Demidov V. I. , Kalacheva A. G. , Bogacheva T. E. , Torshin I. Yu. , Gromova O. A. , Rastashansky V. V.
Published: July 2024

Background. Lithium salts are used in psychiatry and may exhibit neuroprotective effects due to anion constituents.

Objective: to study a dose-dependent effect of oral lithium ascorbate (LiAsc) and lithium carbonate on manifestation and severity of primary generalized seizures caused by thiosemicarbazide in rats in vivo.

Material and methods. The study was conducted on 30 Wistar white male rats weighing 200–300 g in five groups: control, lithium carbonate 5 mg/kg, LiAsc 5, 10, 15 mg/kg/day, administered by probing for 14 days. The model of primary generalized seizures was reproduced by intraperitoneally administered 28 mg/kg thiosemicarbazide. The degree of neurological deficit was assessed based on seizure indicators (latency period before seizures, number of seizures and startles, clonic seizures, etc.). Histopathological studies of brain tissue were carried out using morphometry of histological sections on BioVision image analyzer (Austria).

Results. A course of carbonate and LiAsc significantly reduced seizure duration. The use of LiAsc at doses of 10–15 mg/kg/day not only significantly shortened seizure duration (p=0.01), but also increased the latent period before seizures (p=0.03), reduced the number of seizures (р<0.05) as well as rate of developing tonic extension (р=0.01).

Conclusion. LiAsc at dose of 10 mg/kg/day is sufficient for reducing neurological deficits in thiosemicarbazide-induced seizure model, further confirmed by the data of brain histopathological examination and morphometric analysis.
Problematic Social Media Use: Terminology, Prevalence, Psychosocial and Somatic Comorbidity
Authors: Manchuk V.T. , Tereshchenko S.Y. , Shubina M.V.
Published: July 2024

Objective. The research is aimed at analyzing of the problems associated with the terminology and diagnosis of problematic social media use (PSMU) in adolescents, and summarizing data on its prevalence, psychosocial and somatic comorbidity.
Background. The last decades are characterized by the rapid introduction of the Internet into everyday life. Uncontrolled use of social media leading to negative consequences is considered PSMU. According to the modern biopsychosocial model, its formation is based on a combination of biological, psychological and social factors. Among the negative consequences of PSMU, according to data from both domestic and foreign researchers, a wide range of psychosocial and psychosomatic problems are identified.
Conclusions. A literature review shows that PSMU affects a significant proportion of the population (7-26% – depending on measurement methodology and geographical and cultural factors) with a predominance in collectivist societies and in females. To diagnose this pathology, the European research group “European network for problematic usage of the Internet” suggests using the Social Media Disorder Scale (SMDS) questionnaire, which has shown high validity and reliability. Personal characteristics such as narcissism, neuroticism, impulsivity, low self-control, low self-esteem, and fear of missing out are considered risk factors for PSMU. Comorbidity of PSMU with anxiety-depressive disorders, attention deficit hyperactivity disorder, obsessive-compulsive disorder, social phobia, aggressive behavior, loneliness and suicidal ideation has been established. The association of PSMU with sleep disorders and somatic complaints (chronic pain syndromes, decreased immunity) has been shown. However, most studies have been conducted abroad and focus on generalized Internet addiction (excluding content consumed). In addition, there is insufficient data on the psychosomatic comorbidity of PSMU, especially in adolescents, which indicates the high relevance of such studies.
Characteristics of immunocompetent cells in the testicles of different age group patients with COVID-19
Authors: Demyashkin Grigory A. , Boldyrev Dmitry V. , Vadyukhin Matvey A. , Alieva Lia N. , Shirinov Elmar N.
Published: July 2024

BACKGROUND: There is an opinion that the new coronavirus infection COVID-19 can initiate the development of a local inflammatory reaction in the testicles, which leads to damage to spermatogenic epithelial cells and a decrease in the fertility of patients in the long term.
AIM: Morphofunctional assessment of immunocompetent cells in the testicles of patients with COVID-19 depending on age.
MATERIAL AND METHODS: Based on anamnestic, clinical and morphological data, groups of patients were formed, each of which included subgroups according to the age periodization of the World Health Organization: the first group of patients who died as a result of COVID-19 (n=109; average age 58±2.8 years) — young subgroup (n=19, age 18–44 years), middle-aged subgroup (n=37, age 45–59 years), elderly subgroup (n=53, age 60–74 years); second group (n=30, average age 49±2.3 years; autopsy material from the testicles of patients who died from causes unrelated to COVID-19, obtained outside the pandemic) — a subgroup of young people (n=10, age 18–44 years), middle-aged subgroup (n=10, age 45–59 years), elderly subgroup (n=10, age 60–74 years). Histological and immunohistochemical studies were carried out using primary antibodies to CD3, CD4, CD68, CD163, CD138 and statistical methods: Kolmogorov–Smirnov test, Student's t-test, Mann–Whitney U test and Fisher test.
RESULTS: All testicular samples from patients with COVID-19 revealed signs of viral orchitis and a significant decrease in the spermatogenesis index (in young people — 5.9±0.2% with p=0.02; in middle age — 5.1±0.2% with p=0.008; in the elderly — 3.6±0.1% at p=0.006) compared to the control group (6.8±0.3%), and in immunohistochemical studies — an increase in the number of T-lymphocytes (CD3+, CD4+), macrophages (CD68+, CD163+) and plasma cells (CD138+) in interstitial tissue. In addition, a significant decrease in the spermatogenesis index (3.6±0.1% in the elderly versus 5.9±0.2% in the young, p=0.007) and a decrease in the number of T-lymphocytes (CD3+, CD4+) and macrophages (CD68+, CD163+) was found in older versus younger patients with COVID-19.
CONCLUSION: In patients with COVID-19, an increase in the number of immunocompetent cells (CD3+, CD4+, CD68+, CD138+, CD163+) in the interstitial tissue of the testicles was found, especially pronounced in the elderly group.
Evaluation of the treatment effectiveness in patients with stage IIB–IIIB ovarian cancer
Authors: Zhurman Varvara N.
Published: July 2024

BACKGROUND: The relevance of the study is due to the urgent problem of assessing therapy effectiveness for stage IIB–IIIB ovarian cancer.
AIM: Study of patients' survival rates after surgical treatment of various forms of stages IIB–IIIB of ovarian cancer depending on a number of clinical and morphological factors.
MATERIAL AND METHODS: The material for the study was long-term observations of patients who received treatment from 2004 to 2021 at the Primorsky Regional Oncology Dispensary, the source was the medical record of an inpatient (form 003/u). The group of patients with stage IIB–IIIB ovarian cancer consisted of 107 patients, average age 50.7±11.5 years. Of these, 43 (40.2%) were women with stage IIB, 46 (43.0%) patients with stage IIIA, 3 (2.8%) patients with stage IIIA2, 15 (14.0%) patients with stage IIIB. Overall survival and progression-free survival were assessed. Statistical methods included survival analysis using the Kaplan–Meier method with the construction of survival curves, medians and standard errors of survival time, and comparison of survival between groups of patients using the log-rank test.
RESULTS: In patients with low-grade serous carcinoma, the five-year progression-free survival rate was higher than in patients with high-grade serous carcinoma (71.1±13.5 and 39.5±7.7%, respectively; p 0.01). Primary surgical treatment performed in gynecological hospitals reduced the median life expectancy and five-year survival rate by 150.0 months and 25.9% (p 0.01; RR=3.4; 95% CI=1.2–9.4). Interval cytoreduction reduced the median time to progression and five-year progression-free survival in patients with stage IIB–IIIB ovarian cancer (53.0±35.2 months and 43.7±16.5%) compared with patients underwent primary surgery (70.0±37.5 months and 57.3±6.0%). The five-year survival rate was higher in patients receiving a combination of platinum and taxanes — 94.7±5.1% (p 0.01; HR=0.2; 95% CI=0.05–0.5).
CONCLUSION: In patients with stage IIB–IIIB ovarian cancer, factors such as primary surgical treatment performed in specialized gynecological oncology hospitals and adjuvant chemotherapy with platinum drugs in combination with taxane agents statistically significantly increase survival.
Comorbidity of chronic heart failure of ischemic etiology and chronic obstructive pulmonary disease: 5-year follow-up
Authors: Khazova Elena V. , Boulashova Olga V. , Iakubova Violetta M. , Malkova Maria I.
Published: July 2024

BACKGROUND: The combination of chronic heart failure and chronic obstructive pulmonary disease contributes to the formation of the phenotype and survival of patients.
AIM: To study the 5-year prognosis and develop a prognostic model of adverse events in patients with chronic heart failure of ischemic origin in comorbidity with chronic obstructive pulmonary disease.
MATERIAL AND METHODS: Clinical signs of patients with chronic heart failure of ischemic origin (n=517), including those in combination with chronic obstructive pulmonary disease (n=118), and outcomes over 5 years according to end points: death from all causes, cardiovascular death, composite endpoint — all fatal and non-fatal cardiovascular events, were studied. Quantitative variables were presented as mean and standard deviation or median and interquartile range; categorical — in the form of absolute value and percentage. Quantitative intergroup differences were assessed using the Mann–Whitney test, and categorical differences were assessed using the Pearson χ2 test. Time to event was analyzed using the Kaplan–Meier method; hazard ratio — by Cox regression. Models were developed using binary logistic regression. Statistical processing was carried out in the Jamovi, R 4.3.1 programs.
RESULTS: The clinical portrait of a patient with chronic heart failure of ischemic origin in the presence of chronic obstructive pulmonary disease was characterized by a predominance of men in older age groups, a high frequency of smoking, a worse quality of life, determined by the Minnesota Questionnaire, and a high level of high-sensitivity C-reactive protein, α1- and α2-globulins. Patients with heart failure in the presence of chronic obstructive pulmonary disease had higher overall and cardiovascular mortality (p=0.029 and p=0.02), the frequency of hospitalizations not related to cardiovascular disease (p=0.02), less non-fatal cardiovascular events (p=0.04).
CONCLUSION: In patients with heart failure, the presence of chronic obstructive pulmonary disease increased the risk of death from all causes by 2.07 times, cardiovascular mortality by 2.24 times, and achieving the combined endpoint by 1.68 times. Regression models were developed to determine the probability of risk of death from all causes and cardiovascular death.