bluuebunny/crossref_metadata_2025 huggingface dataset:
УПРАВЛІННЯ РОЗВИТКОМ ПІДПРИЄМСТВА НА ОСНОВІ КОМПЛЕКСНОЇ ТЕХНОЛОГІЇ: СТРАТЕГІЧНИЙ ТА ІННОВАЦІЙНИЙ АСПЕКТ
Authors: ВЛАСЕНКО Тетяна , РЕВЕНКО Олена
Published: February 2024

В сучасних умовах значна частка підприємств, чий бізнес активно розвивається, шукають нові способи підвищення ефективності та конкурентоспроможності. З’ясовано, що переваги технологічного менеджменту на підприємстві стають рушійною силою стратегічних змін, а також його конкурентною перевагою.

Проведено аналіз взаємозв’язку складових системи управління розвитком підприємства, сформованої на основі комплексної технології. Ключовими принципами забезпечення  ефективної реалізації комплексної технологій на всіх етапах розвитку підприємства є: принципи раціональності,  оптимізації та системності. Доведено, що для досягнення високих стійких результатів в системі управління розвитком підприємства слід забезпечити поєднання інноваційного та стратегічного аспектів при плануванні та оцінці управлінських технологій. Визначено, що впровадження інформаційних систем вимагає значних стратегічних змін в управлінських практиках, а також високої кваліфікації персоналу.
Exploring the functional roles of sustainable dietary patterns on gut microbiota composition and optimal health
Authors: Apalowo Oladayo , Adegoye Grace , Obuotor Tolulope
Published: February 2024

The aging population presents a growing global challenge, due to increased risk of age-related diseases, leading to arising burden on healthcare systems and highlighting the need for effective interventions to promote healthy aging. Emerging evidence suggests that certain dietary patterns can influence the gut microbiome favorably, potentially mitigating age-related chronic diseases and metabolic dysfunction such as diabetes, obesity, and cardiovascular diseases. Gut microbiota dynamics, initially stable in early life, are disrupted with age, impacting both prokaryotic and eukaryotic symbionts, resulting in an adaptive response in the gut microbiota defined by an increase in composition and diversity over time. In addition to environmental and genetic factors, the impact of diet has been noted as a critical factor that influences these dynamics. In this review, we propose sustainable dietary patterns like the Mediterranean, vegetarian, ketogenic, and DASH diets as a suitable panacea to counteract deleterious feeding patterns by offering nutritious and environmentally sustainable options, potentially lowering the prevalence of chronic diseases and further explores their functional roles with respect to modulating the gut microbiota composition, and their overall impact on optimal health.
Keywords: Aging; healthy diet; Gut microbiota; Mediterranean Diet; Plant-based diet; dietary intervention
Técnicas de estudio y rendimiento académico
Authors: Choque Efraín , Zanga Marcelo
Published: February 2024

La investigación relaciona las técnicas de estudio que los estudiantes utilizan con el rendimiento académico. El estudio determinó que existe una relación estrecha entre las variables debido a que los estudiantes utilizan las técnicas de estudio; sin embargo, aquellos con rendimiento sobresaliente lo hacen de manera más efectiva. Además se identificó que los hábitos adquiridos en la familia, y sus primero años de formación repercuten significativamente en el rendimiento.
Habilidades de pensamiento y aprendizaje
Authors: Maita Montevilla Jenny Judith , Choque-Medrano Juan Wilfredo
Published: February 2024

Las habilidades de pensamiento son herramientas de la inteligencia que permiten ejecutar ciertas tareas indispensables en el proceso de aprendizaje. Conocer en qué medida se han desarrollado dichas habilidades en estudiantes de nivel superior orientará a los docentes a encarar el proceso de planificación del aprendizaje de distinto modo. La investigación estudió el desarrollo de cinco habilidades de pensamiento, a saber, definición, observación, comparación, análisis y síntesis; en estudiantes del sexto semestre de las diferentes carreras de la UAB. Los resultados muestran que el nivel de desarrollo es regular y que la habilidad más desarrollada es la de observación.
Perangkap Tikus Rumahan Otomatis Dengan Sistem Monitoring Berbasis Internet of Things (IoT)
Authors: Ramadhan Muhammad Irvan , Irawan Denny , Suryo Yoedo Ageng
Published: February 2024

Masyarakat saat ini dihadapkan dengan permasalahan adanya gangguan dari hewan pengerat yaitu tikus. Hewan tersebut sangat mengganggu kehidupan manusia dengan cara memakan makanan manusia atau barang-barang yang disimpan di gudang. Berbagai usaha dan cara telah dilakukan untuk mengatasi permasalahan diantaranya menggunakan racun tikus, perangkap tikus konvensional, maupun alat pengusir tikus (pest repeller). Cara-cara tersebut dinilai masih belum efisien untuk mengurangi ataupun membasmi adanya hewan pengerat di sekitar rumah. Penelitian ini akan merancang dan membahas alat perangkap tikus otomatis yang dapat membunuh tikus secara cepat dengan sistem monitoring berbasis IoT. Sistem ini dipergunakan untuk mendeteksi adanya tikus yang masuk ke dalam perangkap melalui sensor, kemudian alat tersebut akan menangkap gambar target secara otomatis melalui modul kamera yang telah terhubung pada sistem kemudian mengirimkan informasi ke mikrokontroller yang akan dikonversi menjadi pesan teks dan gambar yang kemudian dikirim melalui aplikasi telegram pada handphone. Pengujian pada alat ini membuktikan bahwa alat ini dapat bekerja dengan baik dan mampu membunuh tikus dalam kurun waktu kurang dari 10 detik. Alat ini mampu membuang bangkai tikus secara otomatis serta memberikan pdemberitahuan berupa teks serta link alamat IP privat melalui telegram yang dinilai sangat cocok sebagai media pengirim notifikasi.
Implementasi Pengukuran Detak Jantung Dan Elektrokardiografi Sebagai Alat Kesehatan Mandiri Terintegrasi Internet of Things
Authors: Ermanda Byan , Latifa Ulinnuha
Published: February 2024

Dalam tubuh manusia memiliki organ yang saling bekerja sama untuk membuat suatu sistem sehingga dapat bekerja dengan baik, salah satunya adalah sistem kardiovaskular. Terdapat beberapa metode yang dapat dilakukan untuk mengukur laju detak jantung, seperti Stetoskop, Elektrokardiogram (EKG), Phonocardiogram (PCG) dan Auskultasi. Pada penelitian ini bertujuan mengimplementasikan pengukuran detak jantung dan EKG secara cepat dan tepat, merancangan pengukuran detak jantung yang terintegrasi dengan IoT serta merancang sistem aplikasi dengan menggunakan Kodular. Penelitain ini menggunakan Sensor MAX30102 sebagai pengukuran detak jantung, dan sensor AD8232 sebagai pengukuran EKG, lalu terdapat LCD (Licuid Crystal Display) TFT 3,5 inch sebagai tampilan hasil. Selain itu terdapat aplikasi yang diranngan menggunakan Kodular sebagai tampilan Internet of Things (IoT) dan penyimpan riwayat pengukuran. Pada pengujian menghasilkan akurasi sebersar 97,07%. Pada pengukuran detak jantung ini sesuai dengan spesfikasi pada alat ini. Sinyal elektrokardiografi yang ditampilkan pada LCD terlihat lebih rapat. Sedangkan hasil yang ditampilkan oleh oscilloscope terlihat serupa. Pada penelitian ini menggunakan Firebase sebagai database dan penyimpanan data sementara sebelum data tersebut ditampilkan di aplikasi.
Collective mobility power: Grassroots unionism in the Italian meat-processing sector
Authors: Piro Valeria
Published: February 2024

In the last decade, several sectors of the Italian labour market have witnessed a rise in conflictual union activities carried out mostly by subcontracted migrant workers. Taking two grassroots unions in the North Italian meat processing sector as case studies (SICobas and ADLCobas), this paper investigates why and how migrant workers organise themselves through rank-and-file unions. In particular, the paper aims at understanding whether and how migrant workers' mobility power interplays with and influences their associational power, shedding light on the nexus between labour mobility and its mobilisation. After illustrating how grassroots unions develop in the Italian context, the paper analyses how migrant workers enhance their mobility power through rank-and-file unions and how these unions, in turn, utilise members' mobility as a resource to broaden their organisations. In conclusion, the paper argues that the presence of a highly mobile labour force does not weaken and could even strengthen mobilisations. Consequently, mobility power can be conceptualised not only as an individual strategy but also as a collective resource.
Pengaruh Pemberian Insentif dan Komitmen Organisasi Terhadap Disiplin Kerja Pegawai Puskesmas Gandrungmangu 2 Kabupaten Cilacap
Authors: Mahardika Dimas Pra , Budianto Apri , Herman Ferey
Published: February 2024

Masalah-masalah berikut berada di latar belakang penelitian ini: Seperti yang terlihat dari kehadiran karyawan yang terus-menerus buruk, disiplin kerja individu masih subpar. Banyak orang meninggalkan rumah mereka lebih awal dari yang diharapkan. Karyawan memiliki pekerjaan kedua, seperti kebiasaan bekerja dari rumah, jadi ada persyaratan untuk melaporkan ke tempat kerja lain sebelum jam kerja berakhir, sehingga tingkat disiplin staf masih terbatas. Petugas Puskesmas Gandrungmangu II sering datang terlambat untuk bekerja, tidak muncul di Pushesmas tanpa memberikan bukti, tidak mengikuti apel di pagi dan sore hari, dan menyalahgunakan jam kerja untuk tujuan lain sebagai akibat dari tidak menerapkan sanksi. Kepatuhan petugas terhadap peraturan kerja tidak dipertahankan pada standar hukuman tertinggi. Tujuan dari penelitian ini adalah untuk memahami dan mengevaluasi bagaimana memberikan insentif dan komitmen organisasi mempengaruhi etika kerja Puskesmas Gandrungmangu 2 Kabupaten Cilacap. Metode kuantitatif dan deskriptif digunakan. Temuan penelitian menunjukkan bahwa memberikan insentif mempengaruhi disiplin kerja karyawan dengan cara yang baik dan signifikan. Disiplin di tempat kerja akan meningkat jika insentif digunakan sesuai dengan aturan. Disiplin kerja karyawan secara positif dan signifikan dipengaruhi oleh komitmen organisasi. Komitmen organisasi akan tumbuh bersama dengan tingkat disiplin kerja. Komitmen organisasi dan ketersediaan insentif memiliki pengaruh yang baik dan signifikan pada disiplin kerja karyawan. Disiplin di tempat kerja akan meningkat seiring meningkatnya komitmen dan tingkat insentif organisasi.
Pengaruh Iklim Kerja dan Kompetensi Terhadap Motivasi Kerja Petugas Lapangan Keluarga Berencana (KB)
Authors: Hasilah Een , Budianto Apri , Herman Ferey
Published: February 2024

Hasil penelitian menunjukkan bahwa Iklim kerja berpengaruh positif dan signifikan terhadap motivasi kerja Petugas Lapangan KB Dinas Pengendalian Penduduk Keluarga Berencana Pemberdayaan Perempuan Dan Perlindungan Anak Kabupaten Ciamis. Artinya jika iklim kerja meningkat, maka akan diikuti oleh peningkatan motivasi kerja. Kompetensi berpengaruh positif dan signifikan terhadap motivasi kerja Petugas Lapangan KB Dinas Pengendalian Penduduk Keluarga Berencana Pemberdayaan Perempuan Dan Perlindungan Anak Kabupaten Ciamis. Artinya jika kompetensi meningkat, maka akan diikuti oleh peningkatan motivasi kerja. Iklim kerja dan kompetensi berpengaruh positif dan signifikan
Beyond Intent: An Empirical Study on the Underlying Factors of Cash Waqf Contribution
Authors: Pasaribu Popy Novita , Kemora Haura
Published: February 2024

In pursuit of a flourishing Indonesia by 2045 through the productive waqf movement, collaborative efforts are essential to optimize resources and unleash the full potential of waqf. This research delves into the determinants influencing individuals' inclination to contribute to cash waqf, encompassing variables such as religiosity, education, information influence, comfort, trust in waqf institutions, and perceptions of ihsan. Two independent dummy variables, namely the impact of the covid-19 pandemic on cash waqf and pre-pandemic cash waqf participation, are employed to assess whether past waqf behavior influences future intentions. The dependent variable is engagement in cash waqf. Utilizing a purposively distributed questionnaire via Google Form in Jakarta, 107 responses were obtained through snowball sampling. Regression analysis using SPSS 26.0 revealed that comfort, trust in Waqf Institutions, and Ihsan positively impact the interest in participating in cash waqf. Interestingly, the perception of the covid pandemic did not affect the intention to contribute cash waqf, but individuals who had previously participated in cash waqf before the pandemic exhibited a significant likelihood to continue their contributions.
Impact of Image Pre-processing Methods on Computed Tomography Radiomics Features in Chronic Obstructive Pulmonary Disease
Authors: Au Ryan Chun-Hin
Published: February 2024

Computed tomography (CT) imaging texture-based radiomics analysis can be used to assess chronic obstructive pulmonary disease (COPD). However, different image pre-processing methods that are commonly used, and how these different methods impact radiomics features and lung disease assessment, is unknown. Here, an image pre-processing pipeline was developed to investigate how various pre-processing combinations impact radiomics features and their use for COPD assessment. Image pre-processing techniques that were investigated included airway segmentation, image resampling, and application of either no pre-processing, binning, edgmentation, or thresholding pre-processing techniques. Image resampling and the different preprocessing techniques had the greatest effect on radiomics features. Features generated using the resampling/edgmentation and resampling/thresholding combinations, regardless of airway segmentation, performed the best in COPD classification, and explained the most variance with 2 lung function (R ≥0.353). Therefore, the image pre-processing methods completed prior to CT radiomics feature extraction significantly impacted extracted features and their ability to assess COPD.
The Development of Theranostic Agents for Photoacoustic Detection and Laser-activated Anti-HER2 Breast Cancer Therapy
Authors: Wang Yan Jie
Published: February 2024

Breast cancer is one of the most common malignancies among women. Mammography and ultrasound imaging modalities are routinely used as breast cancer screening procedures. The sensitivity of those modalities decreases significantly in patients with dense tissues and advanced stage breast cancer. Photoacoustic (PA) imaging, as a non-invasive modality, may offer increased sensitivity for screening breast tumors. To probe additional, specific structural and molecular information, targeted exogenous contrast agents are often introduced. Gold nanorods (GNRs) are effective contrast agents in PA imaging due to their high optical absorption at the near-infrared band and superior biocompatibility. The high spatial localization of GNRs provides significant increases in signal amplitude within the target tissue and assists nanoparticle-mediated cancer therapy. I proposed using targeted theranostic agents containing GNRs for breast tumour detection using a photoacoustic method and laser-activated therapy. In this work, I have developed polymeric nanoparticles (NPs) for the imaging and treatment of breast cancer over-expressing human epidermal growth factor receptor 2 (HER2). These NPs contain a perfluorohexane liquid and gold nanorods (GNRs) interior stabilized by biodegradable and biocompatible copolymer PLGA-PEG. Water-insoluble therapeutic drug Paclitaxel (PAC) and fluorescent dye are encapsulated into the PLGA shell. The NP surfaces are conjugated to the HER2-binding antibody Herceptin to target HER2-positive cancer cells actively. The NP uptake by tumor is evaluated using multi-spectral PA imaging. The effectiveness of cancer cell treatment by laser-induced particle vaporization and stimulated drug release are investigated in vitro. The therapeutic efficacy on tumours is also performed using a xenograft mouse bilateral tumor model. PA quantitative analysis demonstrates that these NPs actively target HER2 positive cells with high efficiency. The laser-induced vaporization causes more damage to the targeted cells versus PAC-only and negative controls. The relative concentrations of GNRs in the tumour with peak signal at 6 hours are quantified using a linear spectral unmixing technique. The therapeutic efficacy of these nanoparticles is evaluated using tissue immunofluorescence and histology. In this dissertation, PLGA-PEG-GNRs as theranostic agents for anti-HER2 breast cancer therapy are developed. They may provide better diagnostic imaging and therapeutic potential than current methods for treating HER2-positive breast cancer.
Predictive Modelling of Stack Effect Using Machine Learning Algorithms in High-Rise Office Buildings
Authors: Chang Gary
Published: February 2024

Stack effect adversely affects heating loads in high-rise buildings due to excess infiltration caused by pressure differentials. Mitigating the effects of this phenomenon is crucial to meet the increasingly ambitious energy targets such as Canada’s commitment to COP21. A novel datadriven modeling approach is implemented in order to classify instances where stack effect is detrimental to building performance based on the pressure differentials, building automation system (BAS), and weather data. Various machine learning algorithms were tested with K-nearest neighbor (KNN) achieving the best results for stack effect detection via pressure differentials with an accuracy of 97.7%. The research also investigated potential methods of simplifying stack effect detection by using BAS data as a proxy variable with the best model being able to correctly classify 77.5% of the instances during the cooling season.
Improving Performance and Scalability of Onsite Renewable Energy Using Building-Level Microgrids
Authors: Lytle Jeremy
Published: February 2024

Onsite renewable energy systems are important components of sustainable buildings due to their ability to offset increasing electricity demand, aid in grid decarbonization, and provide energy resilience at the point of consumption. However, typical approaches to design and integration often fail to capitalize on these potential benefits and are ultimately limited in achievable penetration due to a variety of barriers. In this work, building-level microgrids are assessed as an alternative integration mechanism for onsite renewables, which may overcome many barriers to implementation. Key design variables including load segmentation, battery control and generator diversification are evaluated in a simulation-based comparative analysis of performance across grid integration and resilience. Results show that isolated microgrid topologies improve the grid integration performance of a building with onsite renewables across metrics including peak load, ramp rates and generation multiple. It is also shown that renewable microgrids can be leveraged to provide reliable energy resilience, and battery control strategies employing predictive charging and adaptive reserve capacity management can enhance energy resilience with limited storage capacity. Ultimately, the work suggests that the design focus and capital allocation for renewable energy systems in buildings should shift from purely net-zero energy targets, towards delivering more holistic benefits to both the building occupants and the broader power system.
Solar Generation Potential of Residential Neighbourhoods in an Urban Area of Downtown Toronto
Authors: Bashar Farabi
Published: February 2024

Pollution, energy security and climate change are the drivers that put into motion the need to shift to renewable energy sources from fossil fuels. Arguably one of the most promising and reliable renewable sources of energy available today is the electricity generated from photovoltaic solar panels (PV modules). This research quantifies the amount of electricity that can be generated within two 100 years old Cabbagetown residential neighbourhoods in Toronto. Renewable energy sources have relatively low geographic density and at most times are spread out over large areas sparsely. Therefore, implementation of solar PV modules in urban areas, where the land price is more with higher opportunity costs, are the perfect places to promote such solar technologies. This research study used cloud-based solar design software called Helioscope to calculate the total solar electrical production of the homes that represent the neighbourhood. Furthermore, through national resources of Canada data’s the total energy consumption of the same analyzed houses was calculated to analyse how much of the typical electricity use can be offsetted through roof top solar generation. Additionally, limiting factors like shade from trees and surrounding buildings, solar irradiance values, and orientation of the rooftop PVs were analyzed to see how they affected the solar potential. This analysis provides a better understanding of the potential of solar energy generation in the existing, established urban areas such as Cabbagetown in Toronto, and the methodology can act as a template for future studies in other places in Canada as well as internationally. .
Towards Analyzing the Impact of Weathering on the Performance of Mass Timber: Considering Moisture Cycling, Solar Radiation, and Temperature Cycling
Authors: Golkarieh Shirin
Published: February 2024

Cross-laminated timber (CLT) is an engineered wood product consisting of three or more alternating layers of dimension lumber glued together with high dimensional stability. There are chances of several environmental impacts such as exposure to multiple periods of rain, high humidity levels, sun radiation, and mould which will age the CLT panels and damage the product over a long period of time. Accelerated aging treatments are laboratory-based methods which simulate the natural degradation mechanism under a controlled condition at a higher speed to evaluate the durability performance of wood panel products. As CLT panels are a relatively new engineered wood product, the effects of aging treatments on its properties have yet to be properly analyzed. The experimental phase of this research includes making CLT panels by following the CLT-handbook instructions in the laboratory and conducting accelerated weathering tests on them. In this research four different types of CLT samples were exposed to two different weathering treatments, namely, “hygrothermal treatment” and “UV light & water spray”. The results were used to conduct comparisons between 5-ply versus 3-ply and edgeglued versus none-edge-glued. The reported density and moisture content changes provide an overview of the physical modifications of the samples. The microscopic pictures that were taken before and after the treatments from the exact same surface edges show the impacts of the moisture and temperature cycling on the surface edges. 5-ply samples experienced higher deterioration than 3-plys at the end of the aging process; edge-glued samples also experienced the most significant cracking. The results of both tests showed that the end grains and the gaps between laminations present the largest risks of wetting in a CLT assembly. The results would be important for future mass timber buildings dealing with active or constant moisture sources and UV light.
The Efficiency of Air Source Heat Pumps as a Reliable HVAC Option For Homes in Future Climate Scenarios Across Canada
Authors: Jones Shane
Published: February 2024

This study investigates the use of air source heat pumps (ASHPs) in a detached residential home. The study aims to assesses the performance of ASHPs to see whether these systems can provide reliable and energy efficient heating and cooling in mild, cold, and very cold climate zones across Canada. This study also investigates how the use of ASHPs in a warming Canadian climate will affect residential TUEI and GHG emission compared to a natural gas furnace within the home. An energy model was constructed in OpenStudio to perform the necessary simulations to compare the ASHP and the natural gas furnace in present and future scenarios. Theoretical analysis was also done to determine whether the ASHP system can provide reliable heating and cooling to detached residential homes inToronto (zone 6A),Vancouver(zone 5A)and QuebecCity(zone7). Findings indicated that ASHP systems would be best suited for residential use inVancouver (zone 5A) across all three weather scenarios (Present 1998-2014, Future 2030-2041 and Future 20562075)due to the milder temperatures annually. The colder climates for Toronto and Quebec City would require supplemental heating to meet the heating demand of the residence in those locations.
Analyzing Typical Multi-residential Building Unit Layouts in Toronto for Optimization in Circadian Lighting, Human Health/ Wellness, and Daylight Availability
Authors: Nareshkumar Abiraahmy
Published: February 2024

All types of light have the ability to influence the circadian photo entrainment. It is a given that people spend many hours of their waking day indoors, and therefore insufficient lighting levels or improper lighting design, whether that be access to natural daylight or artificial light, can lead to disruption in the circadian cycle. This is especially true if there is unwanted light exposure at night. Recent studies have shown the importance of healthy, occupant-centric lighting in buildings, however urban apartment housing remains an understudied building type. This project analyzed typical units in multi-unit residential buildings (MURB) to determine how unit design parameters including unit geometry and aspect ratio, balcony design, and interior finishes impacted daylight and circadian lighting for residents. The simulation based study compared lighting results from two early-stage design tools: Adaptive Lighting for Alertness (ALFA) which measures Equivalent Melanopic Lux (EML), and ClimateStudio which was used to evaluate daylight autonomy (DA). This study tested if unit configurations met either or all of the lighting criteria for Leadership in Energy and Environmental Design (LEED) standard, WELL Building Standard, and the Toronto Green Standard (TGS). A number of typical layouts for single aspect, 1-bedroom, MURB units were tested in various orientations. Using a base case 1:2 aspect ratio, different unit design parameters were tested including orientation, geometry and aspect ratio, window to wall ratio (WWR), and balcony type. Results of this study showed that even units that seem well lit and would meet LEED, do not necessarily meet TGS or WELL. For example, design options with a 1:2 aspect ratio that have a north and west orientation, cannot achieve the WELL Feature 54 Precondition (circadian lighting design) even with a 100% WWR. Results also compared how different rating systems evaluate daylight and the challenges in the assumptions needed for lighting simulation relating to this housing type. Recommendations for evaluating lighting in MURB are discussed, and a critique of current rating tools in relation to MURB are presented.
Simulation and Response Prediction of Shape Memory Alloy (SMA)-based Steel Beam-column Connections with Steel Angles
Authors: Sabouri Ghannad Mohammad Mahdi
Published: February 2024

The main goal of this research is to develop equations which can be used for predicting the cyclic response of steel beam-column connections with superelastic Shape Memory Alloy (SMA) bolts and steel angles. Finite-element (FE) models are developed to simulate the cyclic behavior of SMA connections. The results are then validated against seven specimens from a previous experimental study. The validated models are used to perform sensitivity and response surface studies. Beam web slenderness ratio, SMA bolt diameter, and angle thickness are identified as the most significant factors affecting the cyclic response of SMA connections. Angle yielding is also found to be the dominant limit state in all connections, confirming their robust self-centering response. It is recommended to use beams of lower depth to minimize residual deformations and avoid early bolt fracture in these connections. The developed surrogate models can be used to accurately predict the SMA connections’ cyclic response.
From Design Changes to Lawsuits: An Exploratory Study Using Text Analytics Based on Legal Case Database
Authors: Liu Li
Published: February 2024

Design change is a major issue influencing construction productivity and if handled inappropriately, may lead to lawsuits in extreme cases. Canadian Legal Information Institute (CanLII) database is an open database that houses massive construction legal case document, each containing thousands of words detailing the judge’s deliberation that leads to the final decision. The study proposes a manual labelling method for legal documents and takes a Latent Dirichlet Allocation (LDA) modelling approach as the primary tool to provide fast and accurate categorization and identification of the legal cases. The study concludes that the LDA method can classify and identify legal cases. Exploratory in nature, this study nevertheless confirms the potential of the CanLII database for knowledge discovery in construction management research.
The Evolution and Development of Malaysia's Strategy Towards China (1957-2022)
Authors: Zhao Xinlei
Published: February 2024

This article uses the period from 1957, the year Malaysia gained independence, to 2022, as the research timeline to examine how Malaysia's strategy toward China developed and what variables significantly influenced its development. The study's findings demonstrate that Malaysia, a tiny nation, has developed its relationship with China through four distinct phases: confrontation (1957–1974), non–alignment (1974–1981), balance (1981–2018), and the "new" hedging approach (2018-2022). Five main factors, including leadership qualities, domestic interest groups, national interest considerations, great power rivalry, and ASEAN principles, all play a role in the evolution of Malaysia's strategy toward China over the course of four phases, according to Robert Putnam's Two-Level Game Theory. Of these, national interest considerations and great power rivalry are the most important influencing factors. Although Malaysia's various strategic decisions and use of China have, to some extent, helped to stabilize bilateral relations and practical cooperation between Malaysia and China, they also demonstrate that Malaysia, as a small and sensible country, is cautious and concerned when establishing relations with China. Due to these complex variables, Malaysia will modify its China policy to reflect the current environment in order to better respond to changes in both domestic and global circumstances and advance its own national interests.
Mapping and Analyzing E-Government Sentiments in Local Governments in Indonesia
Authors: Widodo Joko , Kusnan Kusnan
Published: February 2024

This study aims to comprehensively map and evaluate the quality of E-Government services in local governments throughout Indonesia, focusing on public perceptions. Employing a descriptive method and qualitative approach, data collection involves non-participant observation. Researchers observed the implementation of E-Government within provincial-level local governments participating in the 2021 Electronic-Based Government Systems evaluation through Google Play. Data analysis utilizes an interactive model to provide nuanced insights. The findings reveal that E-Government implementation in Indonesian provincial governments is primarily concentrated within the E-Service category, comprising 50% or 89 applications. The most advanced category is E-Information, encompassing 38% or 67 applications. However, the E-Participation category is notably underrepresented, with only 15% or 19 applications implemented by provincial governments in Indonesia. This study contributes to a deeper understanding of Indonesia’s current landscape of E-Government services. It underscores the importance of further developments, particularly in promoting citizen participation and engagement.
PIGMENTUM: an easy pigment-based tool for monitoring phytoplankton community composition
Authors: Bilbao J , Seoane S
Published: February 2024

Phytoplankton monitoring is essential for understanding the functioning of aquatic ecosystems and for assessing water quality. Based on pigment analysis, different mathematical tools have been developed to relate pigments and phytoplankton groups and determine the contribution of each of these groups to the total phytoplankton biomass. However, most of these tools have several drawbacks, such as the need for a minimum sample number or previous knowledge on community composition. The present study proposes a new chemotaxonomic tool, ‘PIGMENTUM’, based on simultaneous equations that take into account the lack of exclusiveness of diagnostic pigments and which defends the use of ‘pigment groups’ to define the community composition over ‘taxonomic groups’. Additionally, PIGMENTUM does not require prior knowledge on the community composition of the study area, generic pigment ratios are applied, samples are treated independently and it allows individualised ratio correction if necessary. The accuracy of PIGMENTUM was tested with a data series of 330 samples containing different trophic statuses (0.1-251 μg l-1 of chlorophyll a [chl a]) and water masses (salinities between 0 and 36 PSU). The median similarity between the calculated and the real chl a was 82%, and 98% of the samples obtained reliable results, with the tool being especially accurate for eutrophic and hypereutrophic waters. PIGMENTUM was thus proven efficient for phytoplankton monitoring in a wide variety of aquatic systems and environmental conditions, allowing monitoring the variability of the community over time and space and/or determining the groups causing eutrophication or isolated blooms, without the need for using additional techniques.
VASİYETNAME İLE YAPILAN BELİRLİ MAL BIRAKMA VASİYETİNİN SAĞLARARASI TASARRUFLA GERİ ALINMASI
Authors: Altın Şahin Hayrunnisa
Published: February 2024

Vasiyetname ile yapılan belirli mal bırakma vasiyetinin sağlararası tasarrufla geri alınması 4721 sayılı Türk Medeni Kanunu m. 544/II hükmünde düzenlenmektedir. Bu hükme göre, mirasbırakan belirli mal bırakma vasiyetiyle bağdaşmayan sağlararası tasarrufta bulunursa vasiyet geri alınmış sayılır. Türk Medeni Kanunu m. 544/II hükmü uyarınca vasiyetnamenin veya belirli mal bırakma vasiyetinin tamamen veya kısmen geri alınması mümkündür. Bu hükmün uygulanabilmesi için geri alınan ölüme bağlı tasarrufun vasiyetname içerisinde yer alan belirli mal bırakma vasiyeti niteliğinde olması, mirasbırakanın bu vasiyetle bağdaşmayan geçerli ve iradi sağlararası tasarrufta bulunması, bu tasarruf sonucunda belirli mal bırakma vasiyetinin ifasının mümkün olmaması ve mirasbırakanın iradesinin vasiyetin geri alınması yönünde olması gerekir. Bu çalışmada, vasiyetname ile yapılan belirli mal bırakma vasiyetinin sağlararası tasarrufla geri alınmasına ilişkin Türk Medeni Kanunu m. 544/II hükmünün amacı, uygulanma alanı ve şartları ele alınmaktadır. Bu hükme ilişkin özel durumlar ve tartışmalı meseleler, doktrindeki görüşler ve yargı kararları göz önünde bulundurularak incelenmektedir.
Peningkatan Kemampuan Membaca Anak Usia Dini Usia 5-6 Tahun Melalui Media Flashcard Di Tk As-Syifa Curug-Tangerang
Authors: Nurhayati Nurhayati , Rosita Rosita
Published: February 2024

One component of language development is the ability to read and recognize the letters of the alphabet from A to Z. Children's reading ability requires the right stimulus in order to develop reading skills according to their age. Flashcard media is one of the media to develop reading skills. The research approach used in this study is the classroom action research method (CAR), the subjects in this study were teachers and students of Kindergarten B with a total of 2 teachers of Kindergarten B and 21 students of Kindergarten B in Kindergarten As-Syifa Curug-Tangerang, so all subjects were present. 23 people. Data collection techniques were observation, interviews and documentation. Data validation used the triangulation method. The results of the study revealed that the use of flashcard media was able to develop children's reading skills through the smart box game method with the help of pictures and letters from the A-Z alphabet. Flashcard media can make children interested, easy to remember new vocabulary, able to mention the shape and sound of letters, practice listening skills and stimulate children to think and then make children able to express their imagination. years at As-Syifa Kindergarten Curug-Tangerang with the smart box game method.
High-resolution acoustic mapping of tunable gelatin-based phantoms for ultrasound tissue characterization
Authors: Badawe Heba M. , Raad Petra , Khraiche Massoud L.
Published: February 2024

Background: The choice of gelatin as the phantom material is underpinned by several key advantages it offers over other materials in the context of ultrasonic applications. Gelatin exhibits spatial and temporal uniformity, which is essential in creating reliable tissue-mimicking phantoms. Its stability ensures that the phantom’s properties remain consistent over time, while its flexibility allows for customization to match the acoustic characteristics of specific tissues, in addition to its low levels of ultrasound scattering. These attributes collectively make gelatin a preferred choice for fabricating phantoms in ultrasound-related research.

Methods: We developed gelatin-based phantoms with adjustable parameters and conducted high-resolution measurements of ultrasound wave attenuation when interacting with the gelatin phantoms. We utilized a motorized acoustic system designed for 3D acoustic mapping. Mechanical evaluation of phantom elasticity was performed using unconfined compression tests. We particularly examined how varying gelatin concentration influenced ultrasound maximal intensity and subsequent acoustic attenuation across the acoustic profile. To validate our findings, we conducted computational simulations to compare our data with predicted acoustic outcomes.

Results: Our results demonstrated high-resolution mapping of ultrasound waves in both gelatin-based phantoms and plain fluid environments. Following an increase in the gelatin concentration, the maximum intensity dropped by 30% and 48% with the 5 MHz and 1 MHz frequencies respectively, while the attenuation coefficient increased, with 67% more attenuation at the 1 MHz frequency recorded at the highest concentration. The size of the focal areas increased systematically as a function of increasing applied voltage and duty cycle yet decreased as a function of increased ultrasonic frequency. Simulation results verified the experimental results with less than 10% deviation.

Conclusion: We developed gelatin-based ultrasound phantoms as a reliable and reproducible tool for examining the acoustic and mechanical attenuations taking place as a function of increased tissue elasticity and stiffness. Our experimental measurements and simulations gave insight into the potential use of such phantoms for mimicking soft tissue properties.
Revisited and innovative perspectives of oral ulcer: from biological specificity to local treatment
Authors: Pan Ziyi , Zhang Xu , Xie Wangni , Cui Jing , Wang Yue , Zhang Boya , Du Liuyi , Zhai Wenhao , Sun Hongchen , Li Yunfeng , Li Daowei
Published: February 2024

Mouth ulcers, a highly prevalent ailment affecting the oral mucosa, leading to pain and discomfort, significantly impacting the patient’s daily life. The development of innovative approaches for oral ulcer treatment is of great importance. Moreover, a deeper and more comprehensive understanding of mouth ulcers will facilitate the development of innovative therapeutic strategies. The oral environment possesses distinct traits as it serves as the gateway to the digestive and respiratory systems. The permeability of various epithelial layers can influence drug absorption. Moreover, oral mucosal injuries exhibit distinct healing patterns compared to cutaneous lesions, influenced by various inherent and extrinsic factors. Furthermore, the moist and dynamic oral environment, influenced by saliva and daily physiological functions like chewing and speaking, presents additional challenges in local therapy. Also, suitable mucosal adhesion materials are crucial to alleviate pain and promote healing process. To this end, the review comprehensively examines the anatomical and structural aspects of the oral cavity, elucidates the healing mechanisms of oral ulcers, explores the factors contributing to scar-free healing in the oral mucosa, and investigates the application of mucosal adhesive materials as drug delivery systems. This endeavor seeks to offer novel insights and perspectives for the treatment of oral ulcers.
Regional climate change adaptation planning: a case study on single-story wooden-frame residential buildings vulnerable to hurricane winds in selected US coastal locations
Authors: Salarieh Babak , Salman Abdullahi M.
Published: February 2024

The projected increase in sea surface temperature due to climate change is expected to substantially intensify future hurricanes. Wooden light-frame residential buildings are particularly vulnerable to hurricane damage, and their risk is expected to increase due to heightened exposure and intensifying hurricanes. Therefore, adaptation strategies need to be planned to reduce damage to such buildings while considering the impact of climate change on hurricanes. This study investigates the effectiveness of various climate change adaptation strategies for coastal wood-frame single-story residential buildings and demonstrates how these strategies can be planned. The study considers the four Representative Concentration Pathways (RCPs) proposed by the IPCC to investigate the impact of climate change on wind hazard and losses. Additionally, three locations in the coastal United States of varying sizes, exposure, and hurricane hazard levels are considered: Harris County, Texas; Mobile County, Alabama; and Miami-Dade County, Florida. The results show that the increase in wind speeds and losses will be non-linear with time. All considered adaptation strategies decreased losses, with some able to completely counter the increasing losses even under high emission scenarios. Investigating the effectiveness of adaptive measures can guide stakeholders in allocating funds and efforts for hurricane risk management and enhancing community resilience.
Biochemical characterization of L-asparaginase isoforms from Rhizobium etli—the boosting effect of zinc
Authors: Sliwiak Joanna , Worsztynowicz Paulina , Pokrywka Kinga , Loch Joanna I. , Grzechowiak Marta , Jaskolski Mariusz
Published: February 2024

L-Asparaginases, divided into three structural Classes, catalyze the hydrolysis of L-asparagine to L-aspartic acid and ammonia. The members of Class 3, ReAIV and ReAV, encoded in the genome of the nitrogen fixing Rhizobium etli, have the same fold, active site, and quaternary structure, despite low sequence identity. In the present work we examined the biochemical consequences of this difference. ReAIV is almost twice as efficient as ReAV in asparagine hydrolysis at 37°C, with the kinetic KM, kcat parameters (measured in optimal buffering agent) of 1.5 mM, 770 s-1 and 2.1 mM, 603 s-1, respectively. The activity of ReAIV has a temperature optimum at 45°C–55°C, whereas the activity of ReAV, after reaching its optimum at 37°C, decreases dramatically at 45°C. The activity of both isoforms is boosted by 32 or 56%, by low and optimal concentration of zinc, which is bound three times more strongly by ReAIV then by ReAV, as reflected by the KD values of 1.2 and 3.3 μM, respectively. We also demonstrate that perturbation of zinc binding by Lys→Ala point mutagenesis drastically decreases the enzyme activity but also changes the mode of response to zinc. We also examined the impact of different divalent cations on the activity, kinetics, and stability of both isoforms. It appeared that Ni2+, Cu2+, Hg2+, and Cd2+ have the potential to inhibit both isoforms in the following order (from the strongest to weakest inhibitors) Hg2+ > Cu2+ > Cd2+ > Ni2+. ReAIV is more sensitive to Cu2+ and Cd2+, while ReAV is more sensitive to Hg2+ and Ni2+, as revealed by IC50 values, melting scans, and influence on substrate specificity. Low concentration of Cd2+ improves substrate specificity of both isoforms, suggesting its role in substrate recognition. The same observation was made for Hg2+ in the case of ReAIV. The activity of the ReAV isoform is less sensitive to Cl− anions, as reflected by the IC50 value for NaCl, which is eightfold higher for ReAV relative to ReAIV. The uncovered complementary properties of the two isoforms help us better understand the inducibility of the ReAV enzyme.
Normal weight obesity is associated with lower AFC and adverse IVF outcomes
Authors: Yao Yangcheng , Liu Wenjuan , Zhang Xiqian , Su Nianjun , Huang Li , Nong Yingqi , Xiao Xiaomin , Liu Fenghua
Published: February 2024

Background

Body weight could be classified into underweight, normal weight and overweight according to percentage of body fat (%BF), and normal weight obesity (NWO) is defined as a normal BMI but a high %BF. While the impact of NWO in women fecundity remain unknow. Therefore, this study aimed to investigate the associations between %BF and reproductive outcomes among in vitro fertilization (IVF) women with normal BMI.

Methods

A total of 469 women were included in this study and were classified into low %BF, normal %BF and high %BF according to previous study. Multivariate generalized regression models were employed to evaluate the associations of %BF with ovarian reserve parameters, IVF outcomes and early pregnancy outcomes. We further run sensitivity analyses by restricted the analysis to young women and those only with tubal factor, respectively.

Results

About 32.2% of normal BMI women were misclassified according %BF, with 16.4% of them were low %BF and 15.8% were high %BF. The high %BF group had significantly lower antral follicle count (AFC) than normal %BF groups, and the AFC showed a tendency of decrease as %BF increased. In sensitivity analysis in young women, high %BF group also had significantly lower number of good-quality embryos when compared to normal %BF groups. The results expanded to all IVF outcomes when analysis restricted to tubal factor women.

Conclusion

In summary, misclassifications of body weight status based on BMI are common according to %BF, and NWO is associated with adverse reproductive outcomes.
Paraprobiotic derived from Bacillus velezensis GV1 improves immune response and gut microbiota composition in cyclophosphamide-treated immunosuppressed mice
Authors: Lee Hyo-Jun , Tran My Thi Hoa , Le Minh Ha , Justine Elsa Easter , Kim Yeon-Ju
Published: February 2024

Paraprobiotics that benefit human health have the capacity to modulate innate and adaptive immune systems. In this study, we prepared the paraprobiotic from Bacillus velezensis GV1 using the heat-killing method and investigated its effects on immunity and gut microbiota in vitro and in vivo. The morphology of inactivated strain GV1 was observed using scanning electron microscopy. Treatment with GV1 promoted nitric oxide production and augmented cytokine (IL-6, IL-1β, and TNF-α) expression and secretion in RAW 264.7 macrophages. Moreover, the strain GV1 could alleviate cyclophosphamide monohydrate (CTX)-induced immunosuppression by reversing spleen damage and restoring the immune organ index, as well as by increasing the expression of immune-related cytokines (TNF-α, IL-1β, IFN-γ, and IL-2) in the spleen and thymus, respectively. Furthermore, GV1 treatment dramatically healed the CTX-damaged colon and regulated gut microbiota by increasing the relative abundance of beneficial bacterial families (Lactobacillaceae, Akkermansiaceae, and Coriobacteriaceae) and decreasing that of harmful bacterial families (Desulfovibrionaceae, Erysipelotrichaceae, and Staphylococcaceae). Thus, the heat-killed GV1 can be considered a potential immunoregulatory agent for use as a functional food or immune-enhancing medicine.