bluuebunny/crossref_metadata_2025 huggingface dataset:
Classification of Grievances in Hello Sarkar using Supervised Machine Learning
Authors: Subedi Binaya , Joshi Basanta
Published: January 2025

Classification of Grievances automatically as per some pre-defined category is an automated task that can be carried out with the aid of some confidence gained after learning the content from a training set of grievance dataset. This research mainly aims to evaluate widely used supervised machine learning approaches like Naïve Bayes and SVM. For this experiment, the dataset of 4 categories with about 3,000 datasets collected from the official site of ‘Hello Sarkar’ portal which has been used by the Government of Nepal, Office of the Prime Minister and Council of Ministers for handling the public grievances was used. As per the recent research outcomes, none of the researchers had spoken about which machine learning algorithm outperforms the rest of the other and has always suggested that the outcome solely relies on the type of dataset used. So, in this research, above -mentioned machine learning was used and the accuracy of those applied algorithms was compared. As public grievances are either in Nepali, English or in Roman form, the research procedure mainly focused on how well the above-mentioned algorithms perform on those grievances in Nepali language dataset. Moreover, as per the suggestions from various researches conducted previously, the enhancement in accuracy was targeted out by cleaning the dataset by adding the stop words in NLTK corpus and removing extra useless symbols during preprocessing state for refining dataset before the implementation of machine training algorithms.
मुरारि पराजुलीका कवितामा वैचारिकता
Authors: तिवारी Tiwari प्रेमप्रसाद Prem Prasad , पौड्याल Paudyal शालिकराम Shalik Ram
Published: January 2025

प्रस्तुत लेखमा कवि मुरारि पराजुलीका कविताबाट अभिव्यक्त हुने वैचारिकताको अध्ययन गरिएको छ । यस लेखमा प्राथमिक तथा द्वितीयक स्रोतका सामग्रीको उपयोग गरिएको छ । प्राथमिक स्रोतअन्तर्गत मुरारि पराजुलीका सृजनाका स्वरहरू, आगो पालेका पेट र शीत ओडेका बस्तीहरू, हाँसेर उसका ओठले, लोकतन्त्रको शङ्खनाद र हाम्रा छातीको दशगजा पाँचओटा कवितासङ्ग्रह रहेका छन् भने द्वितीयक स्रोतअन्तर्गत सिद्धान्त निर्माणका क्रममा उपायोग गरिएका पुस्तक, समीक्षा, जर्नल तथा सन्दर्भसामग्री रहेका छन् । यहाँ उल्ललेख गरिएका दुवै स्रोतका सामग्रीको सङ्कलन पुस्तकालयीय कार्यबाट गरिएको छ भने सङ्कलित सामग्रीको विश्लेषणका लागि वैचारिकतासम्बन्धी अवधारणाको उपयोग गरिएको छ । यस लेखमा मुरारि पराजुलीका कविताको मुख्य वैचारिक धरातलका रूपमा प्रगतिवादी चिन्तन आएको छ र यसका साथै यिनका कवितामा सामाजिक भावना, राष्ट्रवादी भावना, क्रान्तिकारी विचार, परिवर्तनकारी विचारले मुख्य स्थान प्राप्त गरेका छन् भन्ने कुरा उल्लेख गरिएको छ । नेपाली समाज, राजनीति, यहाँका मानिसको आर्थिक अवस्था, शोषण, दमन, अन्याय, अत्याचार, भ्रष्टाचार जस्ता विकृति तथा विसङ्गतिलाई देखाउँदै नेपाली जनताले भोग्नुपरेको पीडा मुरारि पराजुलीका कविताको मुख्य विषय बनेको छ भने यही विषयको जगमा समाज परिवर्तनसँग सम्बन्धित विविध विचार प्रकट भएका छन् भन्ने कुरा यस लेखको निष्कर्षका रूपमा आएको छ ।
प्रह्लाद नाटकमा मृत्यु चिन्तन
Authors: खतिवडा khatiwada लेखराज Lekhraj
Published: January 2025

प्रस्तुत लेखमा नाटककार बालकृष्ण समले लेखेको प्रह्लाद नाटकमा व्यक्त भएको मृत्यु चिन्तनको खोजी गरिएको छ । समले विष्णुपुराणमा पाइने हिरण्यकशिपु र उसको छोरो प्रह्लादसँग सम्बन्धित घटनालाई नाटकीकरण गरी प्रस्तुत नाटक लेखेका हुन् । छोरो प्रह्लाद आफ्नो विरोधी देखिएको र उसले आफ्नो परमशत्रु भगवान् विष्णुको भक्ति गरेपछि हिरण्यकशिपु छोराप्रति ज्यादै क्रोधित भएको र उसले आफ्नै छोेरो प्रह्लादलाई मार्न खोजे पनि ऊ विष्णुका कृपाले बाँचेको तर अन्त्यमा हिरण्यकशिपु आपैmले मृत्युवरण गर्न पुगेको घटनामा पुगी टुङ्गिएको प्रस्तुत नाटकमा मृत्यु चिन्तन व्यक्त भएको पाइन्छ । यस संसारमा जन्मेजति सबै प्राणीको एक दिन अवश्यै मृत्यु हुन्छ भन्ने मान्यता रहेको छ र प्राणीको मृत्युसम्बन्धी प्रचलित यही मान्यता नै मृत्यु चिन्तन हो । प्रस्तुत नाटकमा मुख्यतः यसका प्रमुख दुई पात्र प्रह्लाद र हिरण्यकशिपुका विचार एवम् कार्यव्यापारमार्पmत मृत्युसम्बन्धी धारणा व्यक्त गरिएको छ । त्यस सिलसिलामा प्रस्तुत नाटकमा सबै प्राणीको मृत्यु अवश्यम्भावी छ, मृत्यु नै भयको कारण हो अनि मृत्यु नै मोक्षको मार्ग हो भन्ने मृत्यु चिन्तन प्रह्लाद र हिरण्यकशिपुमार्पmत व्यक्त गरिएको छ । त्यसैले प्रस्तुत लेखमा समले लेखेको प्रह्लाद नाटक मृत्यु चिन्तनको अभिव्यक्तिका दृष्टिले निकै सफल देखिन्छ भन्ने निष्कर्ष निकालिएको छ ।
Between Science and Cinema: Christopher Nolan's Auteurist Vision in Interstellar
Authors: Bhusal Damodar
Published: January 2025

The paper attempts at exploring Nolan's auteurist vision in Interstellar, exploring how he navigates the complex intersection of science and cinema. Employing an interdisciplinary approach that draws from auteur theory, science fiction studies, and narratology, this research conducts an in-depth analysis of Interstellar. It examines Nolan's distinctive stylistic signatures, including his visual aesthetics, nonlinear storytelling techniques, and exploration of scientific concepts such as relativity, time dilation, and astrophysical phenomena. Through a close reading of the film's narrative structure, character development, and symbolic motifs, the paper unravels how Nolan seamlessly integrates complex scientific ideas into the emotional core of the story. It investigates how he creates a harmonious fusion of science fiction and human drama, challenging conventional boundaries and pushing the limits of cinematic representation. Furthermore, this research situates "Interstellar" within Nolan's broader filmography, identifying recurring themes, stylistic choices, and his unique approach to cinematic storytelling. By examining the critical reception and scholarly discourse surrounding the film, the paper contributes to a deeper understanding of Nolan's auteurist vision and his contributions to the representation of science in cinema. Ultimately, the paper offers insights into Nolan's mastery in bridging the realms of science and cinema, illuminating how his auteurist vision in Interstellar expands the possibilities of cinematic storytelling and challenges audiences to engage with complex scientific concepts through the medium of film.
Emerging Trends of using Digital Tools including Artificial Intelligence in Health sector in Nepal: What Next?
Authors: Adhikari Lal Mani
Published: January 2025

The integration of AI and digital technology in Nepal's primary health care system has significantly enhanced diagnostic capabilities, enabling early diagnosis and treatment. The study highlights the use of AI, databases, telemedicine, and mobile apps for disease diagnosis and prevention. AI platforms, particularly those processing radiological images, are the most widely adopted tools. While these technologies have the potential to revolutionize healthcare by improving efficiency, accuracy, and patient outcomes, addressing the existing gaps in policies, regulations and ethical considerations is essential for maximizing their benefits. Further studies are recommended to generate the systematic evidences of adopting digital health solutions for enhancing Nepal’s healthcare system.
Analysis of workload and fatigue Batik Cap workers in Sukoharjo
Authors: Lestari Mathilda Sri , Komariah Ainur , Suprapto Suprapto , Sari Maria Puspita
Published: January 2025

Batik is an ancestral heritage of the Indonesian people that has been preserved to this day, particularly on the island of Java. In Java, the centers of the batik industry are located in Pekalongan, Yogyakarta, Surakarta, and Sukoharjo. In Sukoharjo, there are several home industries producing batik cloth, especially in the Krendetan Sukoharjo area, which specializes in both written and stamped batik. The batik-making process in these home industries is performed manually using simple tools. A preliminary survey revealed that the batik-making process involves repetitive tasks and imposes a high workload, particularly in the batik stamping process. This study aims to determine energy expenditure during work, energy expenditure during rest, and energy consumption needs for workers in the batik industry. The research was conducted in the stamping section and the boiling process to remove wax from the fabric. The results showed that energy expenditure during the batik stamping process was 382 kcal/hour, while in the boiling process it was 402 kcal/hour. Energy expenditure during rest was 354 kcal/hour in the stamping process and 367 kcal/hour in the boiling process. Energy consumption during the stamping process was 29 kcal/hour, and in the boiling process, it was 36 kcal/hour. The required rest time for the stamping process was 7.43 minutes per 15 minutes of work, while for the boiling process it was 5 minutes per 30 minutes of work.
Improving online learning through student stress evaluation
Authors: Sarvia Elty , Wirawan Christina , Kristianti Meilena , Ramadhani Zukhruf
Published: January 2025

The COVID-19 pandemic impacted almost all countries and caused disruptions in education. Governments, including Indonesia, closed schools and campuses to mitigate the spread of COVID-19, leading to a transition to online learning. This lasted for two years and continued with hybrid learning. The abrupt change increased stress, especially for already stressed students. This study assessed stress levels during online learning at the Industrial Engineering Study Programme of Maranatha Christian University, Bandung. Stress was measured subjectively using the Perceived Stress Scale (PSS) and objectively using Galvanic Skin Response (GSR) and pulse sensors on thirty-two students. The PSS results classified the stress perception of most students as ‘normal’ or ‘moderate’. Meanwhile, the results of the GSR and pulse sensor measurements indicated that the students were stressed. Furthermore, a comparison of stress levels between synchronous and asynchronous learning and between mathematics and theory courses was conducted. According to the findings, there was a difference in the average heart rate values between synchronous and asynchronous learning. There was also a difference between mathematics and theory courses. With this research, it is necessary to pay attention to learning methods, materials, etc. need to be designed to reduce student stress and improve student performance.
Factors that influence worker behavior towards occupational safety and health using the SEM-PLS method at PT. Industri Kapal Indonesia (Persero) Makassar
Authors: Herdianzah Yan , Wahyuni P A. Dwi , Ahmad Arfandi , Chantika Aulia Marista Dewi , Saleh Anis , Fole Asrul , Safutra Nur Ihwan
Published: January 2025

PT. IKI is a shipbuilding company owned by the Indonesian government which carries out several industrial activities such as ship building, repair and docking. The results of initial observations found that there were still workers in the production division who experienced work accidents and occupational diseases. In this research, it is very important to analyze the factors that influence the behavior of production division workers to find out what suggestions for improvements are appropriate in overcoming problems with production division workers. This research employs the SEM-PLS method to investigate the impact of knowledge factors (X1), attitudes (X2), and the availability of facilities (X3) on the occupational safety and health of production division workers. It aims to provide valuable insights for enhancing workplace safety by identifying factors that positively influence these outcomes. The findings of this study reveal a significant correlation between the availability of facilities (X3) and occupational safety and health, as evidenced by a p-value of 0.000, which is less than the predetermined significance level of 0.05. Based on these results, recommendations for improvement can be proposed. The company is advised to uphold and enhance the implementation of Standard Operational Procedures about Occupational Safety and Health (K3) while also ensuring the continuous provision of comprehensive Personal Protective Equipment (PPE) for all employees
Development of palm pool brondonal pick up tools to increase time efficiency by VDI 2221 method
Authors: Lucitasari Dyah Rachmawati , Ramadhani Fidah Jihad
Published: January 2025

Koperasi Unit Desa (KUD) aims to improve the welfare of members by carrying out harvesting process activities in Lubuk Kembang Sari, Riau. The problem that often occurs is collecting oil palm fruit which is still done manually by bending or squatting. Previously there was a manual tool which had shortcomings in the form of the design of the chute section which was still less than optimal in the trajectory of throwing the brochures into the container, sometimes the brochures were thrown upwards instead of backwards into the reservoir. Another drawback is that when carrying tools if the distance is quite far then this process is a little difficult. The aim of this research is to develop a loose picker tool from existing design references to increase time efficiency.The development of tools for picking up palm oil loose ends was carried out using the VDI (Verein Deuscher Ingenieure) 2221 method. Development using this method began with analyzing the shortcomings of existing tools and developing farmers' desires and needs for the specifications of new oil palm loose picking tools. After the design concept is created, the next step is to create a customized design using the user's body anthropometry, and the final step is to carry out trials on the palm oil harvester picking tool.This research resulted in a new palm oil harvester tool that is capable of picking up palm oil stalks. The comparison between manual collection and the new tool is that the new tool can speed up the collection time by 28%. A time comparison was also made using the old tool with the new tool, it turns out that the new tool can speed up the time by 54%. Based on user satisfaction tests, the tool is easy for users to operate and is automatic.Keywords: Palm oil fruit, manual tools, time efficiency, VDI 2221
Enhancing customer satisfaction towards the service quality of Soekarno-Hatta International Airport using servqual and binary logistic regression
Authors: Graciela Felice , Satitidjati Dewayana Triwulandari , Habyba Anik Nur
Published: January 2025

The world is experiencing rapid change, leading to transformations in human lifestyles that necessitate adaptation. However, the aviation industry appears to have reached a point of stagnation. Soekarno-Hatta International Airport must adapt to the new needs and demands of passengers by implementing necessary changes and incorporating the latest available technologies. To gain a deeper understanding of passenger satisfaction regarding the service quality at Soekarno-Hatta International Airport, the SERVQUAL method and Binary Logistic Regression Analysis will be employed. Both methods aim to identify services that has significant impact and determine the relative influence of these services on the overall service quality at Soekarno-Hatta International Airport. The results of the SERVQUAL method in this study indicate that there are 14 services at Soekarno-Hatta International Airport that do not meet passenger satisfaction standards, with a need for particular attention to the reliability dimension. Subsequently, the Binary Logistic Regression analysis results indicate that only parking price and ambiance significantly influence passenger satisfaction, with the likelihood of increasing satisfaction being 1.7732783 and 2.0773711 times respectively. Focus should be placed on improving operational accuracy through stringent Standard Operating Procedures (SOPs) and comprehensive staff training, reducing supplementary expenses like toll charges, expanding parking facilities, and optimizing parking flow, improving illumination, customer engagement, and noise control measures.
Optimizing work movements to reduce injury risk: Application development with Methods-Time Measurement and WebQual analysis
Authors: Muzakir Ari , Wahyudi Adhie Tri , Astanti Yuli Dwi , Kusmindari Christofora Desi
Published: January 2025

Optimizing work movements is crucial for enhancing efficiency and reducing injury risks in industrial environments. Methods like Methods-Time Measurement (MTM), Work Factor (WF), and Maynard Operation Sequence Technique (MOST) are commonly used to analyze and optimize the workstations. However, there remains a lack of accessible tools for rapid and accurate time measurement. This study aims to develop a web-based and Android application designed to assist both students and professionals in calculating work times and optimizing movements (such as: material handling) more efficiently. The application was evaluated using the WebQual method, focusing on usability quality, information quality, and interaction quality. Evaluation results yielded scores of 82.3% for usability, 85.7% for information quality, and 80.5% for interaction quality. Validity and reliability tests demonstrated a Cronbach's Alpha coefficient of 87%, indicating very high reliability. The integration of MTM within this application has proven effective in accelerating work time calculations compared to manual methods and in improving movement efficiency, which directly contributes to reducing injury risks.
A hybrid Genetic Algorithm and Fuzzy Logic approach to ergonomic design of workstations in metal casting operations
Authors: Berlianty Intan , Soejanto Irwan , Titisariwati Indun , Putra Favian Ersanta Andhika , Utami Wahyu Tri , Insani Mohamad Kamil
Published: January 2025

The metal casting industry faces significant challenges in balancing productivity with worker safety and well-being. Hazardous working conditions, including high temperatures, exposure to gases, and repetitive motions, increase the risk of injuries and fatigue. 1 This study proposes a novel hybrid approach that integrates Genetic Algorithm (GA) and Fuzzy Logic (FL) to optimize workstation ergonomics. The system utilizes real-time data from sensors to evaluate ergonomic factors such as worker posture, fatigue levels, and environmental conditions. Fuzzy Logic processes this data, while GA optimizes the system's parameters for enhanced accuracy and adaptability. Experimental results demonstrated significant improvements, including a 25% reduction in worker fatigue, a 30% improvement in air quality compliance, and a 35% decrease in ergonomic risks. Real-time adjustments, such as desk height modifications and improved ventilation, effectively enhanced worker safety and comfort. This innovative approach offers a scalable and reliable solution for improving ergonomics in dynamic industrial environments, contributing to both worker well-being and operational efficiency. Future research could further enhance the system by incorporating machine learning for improved predictive capabilities and expanded optimization of ergonomic parameters.
Laicity and conciliation in France and Poland
Authors: Bomba Sarah
Published: January 2025

The article is based on the analysis of the transformation of the consciousness of Polish society and the plans for reforming state-church relations contained in the programmes of the parties created ruling coalition after the elections of 15th October 2023. This transformation is comparable to the dynamics of changes in confessional politics in France in the 1880s. By presenting the historical conditions that translated into the axiology of both countries and their attitudes towards the ecclesiastical institution, the author outlines the main axes of comparison in order to demonstrate the unprecedented identity’s transformation in Polish society. This transformation leads to increasing secularisation that influence the funding of the Catholic Church from the state budget. The analysis was carried out using the literature on the development of secularism in France and Poland, as well as legal sources allowing to outline the legislative framework for the financing of religious associations (particularly the Catholic Church) in contemporary political history
Breaking Down Walls in Post-Pandemic Transnational Fables: Kazuo Ishiguro’s Klara and the Sun and Mohsin Hamid’s The Last White Man
Authors: Chambers Claire
Published: January 2025

Kazuo Ishiguro’s Klara and the Sun and Mohsin Hamid’s The Last White Man are fables that indirectly engage with the COVID-19 pandemic. While neither novel explicitly mentions the pandemic, they offer subtle reflections on this period in our history and forecast COVID’s fallout. Ishiguro uses a childlike persona to explore a dystopian world involving artificial intelligence and gene editing. Hamid elliptically addresses the pandemic in the context of a resurgence of racism and the resilient response from Black Lives Matter activists over the past half-decade. I examine the two authors’ indirect representations of the pandemic and the way in which it triggers reflections on those partitions and fences put up to divide us. The pandemic’s inherently challenging nature for direct representation is echoed in these writers’ decision to create fables not tied to any particular country. While Ishiguro’s and Hamid’s novels evoke ideas about disease, death, and bereavement, they primarily focus on loneliness, digital dependency, and the social divisions that have arisen, especially since 2016 due to events such as Brexit and the election of Donald Trump. Readers look through Ishiguro’s titular cyborg character Klara’s eyes as she tries to make sense of the boxes, rectangles, partitions, and walls that she sees. And Hamid uses absurdism to explore racial classification, whereby characters lose their whiteness and cross over to an unstated ethnicity for the rest of their lives. These authors’ transnational narratives encourage breaking down the metaphorical and physical barriers that have divided people. Through their fable-like storytelling, the novelists strive to connect people and blur the lines that separate us.
Verificando 2018: un caso afortunado de deontología periodística
Authors: Bernardo Masini Aguilera José
Published: January 2025

Masini Aguilera, José Bernardo. Verificado 2018: un caso afortunado de deontología periodística. La proliferación de noticias falsas (fake news) en procesos electorales en otros países, y durante la emergencia suscitada por los sismos de septiembre de 2017 en México, dio lugar a un esfuerzo colegiado para evitar la desinformación ciudadana en el marco de las elecciones presidenciales de 2018. Un grupo de periodistas ofreció su tiempo, su creatividad y su profesionalismo para crear un sistema de validación de información que diluyera el impacto de rumores o de piezas noticiosas de dudoso rigor profesional. El resultado fue un caso afortunado en materia de deontología periodística, que logró desmentir más de 400 noticias falsas y elaborar materiales didácticos para fomentar el consumo crítico de medios de comunicación. En el texto se explica la fundamentación, la metodología y los resultados de esta iniciativa y se presenta una prospectiva en el mediano plazo en materia de alfabetización mediática y derecho a la información.
Evaluating the Upper and Lower Lip as Critical Organs in Radiotherapy for Head and Neck Cancer Patients
Authors: Biedka Patryk
Published: January 2025

Squamous cell carcinoma of the head and neck is condition associated with a poor prognosis. Current treatment methods are a combination of various techniques. Reactions after radiotherapy, particularly those affecting mucous tissues such as the lips, are a major issue after radiotherapy.

This study aimed to assess the doses deposited on the lip area, considering its proximity to target areas during radiotherapy. Study was conducted on 100 patients with diagnosed head and neck cancers. These patients were treated with radiotherapy, sometimes combined with chemotherapy, and for some, it was postoperative treatment. The minimum, average, and maximum doses deposited on the lip area were assessed, divided into group I (neck) and group II (head). The lowest doses were observed in the larynx area, and the highest in the oral cavity (67.7% of the dose from 70 Gy and 76.46% from the minimum dose).

Patients were further divided based on treatment methods, with the highest maximum lip dose found in those undergoing postoperative radiochemotherapy (Dmax 42.34Gy). Post-radiation reactions were then analyzed, showing higher reactions (lowest, average, and maximum) in group II (head area). Tumor location analysis showed the lowest maximum reaction according to the Dische classification in the larynx and other locations, and the highest in the pharynx. Postoperative patients with adjuvant radiochemotherapy had the highest minimal and maximum reactions.

Despite the lack of statistical significance, the results suggest the importance of contouring the lips as a critical organ to reduce radiation reactions, potentially improving patients' quality of life.
Tick bite fever in South Africa (A Rickettsial Disease)
Authors: Denis Solomons Hilary
Published: January 2025

Tick bite fever has been a constant scenario in South Africa. Only recently has it been established that there are two aetiological agents.

These two agents have different epidemiologies and clinical presentations. They are Ricketsia conorii and Rickettsia Africa. Rickettsia Africa is the milder form of the disease. Rickettsia conorii can be fatal! The treatment of choice is doxycycline or tetracycline. Macrolides and quinolones may be of value.
Then and Now: Non metastatic Breast cancer: A Review Literature
Authors: Pandey Ankita
Published: January 2025

Breast cancer is most common cancer worldwide among females. It is most thoroughly studied and investigated area in the field of oncology. It is disease of predominantly young females and has well known etiological factors. The management has evolved from extensive surgery in the past to the limited surgical excision. The awareness among females has also led to earl diagnosis and prompt management. The critical area of interest now lies in the field of radiation therapy where different techniques are used to enhance the local control and improve the cosmesis. This review article focuses on general outline of the anatomy, clinical features, diagnosis and management focusing on the evolution of the radiotherapy techniques especially in early stage breast cancer.
Meningeal large B-cell lymphoma: Beware of the meningioma trap! A case report with review of the literature
Authors: Boujguenna Imane
Published: January 2025

Primary meningeal lymphoma of the central nervous system is extremely rare. Over the past decade, a number of these tumors have been reported to resemble meningioma clinically, intraoperatively and radiologically. We report the clinical, radiological, histopathological and evolutive features of a primary parieto-occipital meningeal lymphoma in a 27-year-old man, which clinically and radiologically resembled an aggressive high-grade meningioma. The patient was initially treated by surgery and then referred to hematology for possible further chemo-radiotherapy. The unfavorable evolution of the patient was due to the neurological sequelae of the surgical resection despite the regression of the tumor process objectified by follow-up imaging. Therefore, primary meningeal lymphoma of the central nervous system should be included in the differential diagnosis of meningioma and warrants anatomopathological and immunohistochemical examination of any surgical specimen and follow-up imaging.
Xanthogranulomatous Cholecystitis with Gallstones: A Case Report
Authors: BOUJGUENNA Imane
Published: January 2025

Xanthogranulomatous cholecystitis (XGC) is a rare, destructive inflammatory disease of the gallbladder, considered a variant of chronic cholecystitis. Its prevalence ranges from less than 1% to 9%. XGC is often mistaken for gallbladder carcinoma prior to histological analysis. We report a case of a 69-year-old patient presenting with chronic hepatic colic, diagnosed with lithiasic xanthogranulomatous cholecystitis confirmed by histopathological examination.
Probiotics as an Alternative Option in Treatment of Allergic Rhinitis. Comparing Probiotics Vs Fexofenadine in treatment of Allergic Rhinitis
Authors: Raghu Krutika
Published: January 2025

Aims

Intermittent treatment with oral antihistamines and nasal sprays are costly, may not completely resolve symptoms and can cause varying degrees of sedation.

Probiotics are perceived to exert beneficial effects in the prevention and treatment of allergic diseases with no side effects.

Method

A prospective study with 120 patients visiting the ENT OPD was carried out for 1.5 years. Patients were randomly assigned into 2 groups and were followed up for a period of 4 weeks.

Results

Nasal congestion was significantly reduced by using probiotics while other symptoms like running nose, itching, sneezing were reduced more by using fexofenadine 120mg. The result was Statistically significant only for the symptom of nasal congestion.

There was not much variation in results of endoscopic appearance of the hypertrophy of inferior tur-binates and in appearance of allergic mucosa.

Headache was the most common adverse effect in the fexofenadine group and allergic reactions was seen in very few patients in probiotics group.

Conclusion

Evaluation of the benefits of probiotics has been hindered due to inadequate clinical trials resulting in the rejection of health claims by regulatory bodies.

Many studies show significant beneficial effects of supplementation only after minimum of 4 weeks of administration. suggesting that supplementation periods in excess of 4 weeks are necessary to assess measurable clinical outcomes.
Effect of Intermittent Fasting on Cancer
Authors: Amel Zemmour
Published: January 2025

Diet is a modifiable factor that may affect cancer risk, treatment and recurrence, currently there is a high level of interest in fasting and cancer in the scientific community but no clear information about the purported health benefits, fasting and fasting mimicking diets leads to wide alterations in growth factors and in metabolite levels giving rise to an unfavorable environment for cell proliferation, there are multiple examples of fasting diets that might regenerate antitumor immunity and may even prevent some types of tumors which are most likely to be sensitive to these dietary interventions, thus, the biologically-relevant interplay between fasting or nutrient deprivation and current cancer treatments encourages the design of future trials to maximize efficacy and achieve the lowest toxicity of current cancer treatments.
Investigation of Tower Crane Accidents in Türkiye between 2013 and 2017
Authors: Kaan Çoktu Ali
Published: January 2025

Booming construction sector requires extensive use of tower cranes. Lacking safety precautions may lead to severe tower crane accidents due to inherent risks. This study provides an in-depth overview of the construction sector, highlighting the significant risk of falling from height as a prevalent hazard and emphasizes the importance of vocational training for employees in the construction sector in Türkiye and presents global statistics on accidents in the construction industry, particularly focusing on tower crane accidents. Starting with worldwide tower crane accidents, their causes, hazards, installation procedures, and the impact of accidents on individuals this study also delves into the analysis of tower crane accidents in Türkiye between 2013-2017, examining various factors such as age, location of injuries, accident causes, and sector involvement. The study underscores the need for enhanced safety measures, training programs, and regulatory enforcement to mitigate accidents in works involving tower crane use.

In Türkiye, 1704 tower crane accidents were reported between 2013 and 2017. The distribution of these accidents by year shows an increasing trend from 2013 to 2017. Additionally, it highlights that 86% of all tower crane accidents occurred in the construction sector. The analysis also uncovers that there is a significant disparity among variables such as age, location of injuries on the body, accident causes, victims' occupations, and the province where the accidents occurred. However, no significant differences were observed among variables like accident time, experience, OSH training, professional education attainment, educational status, season of the accident, and day of the accident.
Perineal Ecthyma Gangrenosum
Authors: E. Naschitz Jochanan
Published: January 2025

Perineal necrotic lesions have a narrow differential diagnosis, when ecthyma gangrenosum (EC) should be considered in priority. A 43-year old woman receiving immunotherapy for metastatic glioblastoma was admitted under clinical deterioration and severe neutropenia. Shortly after admission an erythematous eruption occurred involving the chest and perineum. Within a few hours the lesions evolved from erythema to necrosis. Broad spectrum antibiotics were started. Results of lesional cultures revealed Pseudomonas aeruginosa. The diagnosis of EC was established. A life threatening infection, EC needs to be quickly diagnosed, differentiated from other necrotizing eruptions, and treated in emergency.
Schizophrenia and Viruses: A Focus on Coronavirus Disease (COVID-19)
Authors: Nagy M.A.
Published: January 2025

Viral infection appears to be a general risk factor for psychotic disorders. Coronavirus infection may also be a specific risk factor, conferring acute and long-term risk for psychosis. Even if the increased risk is marginal, the ongoing massive worldwide exposure to COVID-19 is likely to increase the incidence of psychotic disorders as Schizophrenia by a meaningful number of cases. This hypothesis is discussed briefly in this review article.
Clinical Pharmacology of Phenobarbital in Infants and Children
Authors: Pacifici Gian Maria
Published: January 2025

Phenobarbital inhibits seizures by potentiation of synaptic inhibition through an action on the GABAA receptor. Phenobarbital is an effective agent for generalized tonic-clonic focal-to-bilateral tonic-clonic and focal seizures. Phenobarbital may be administered orally or intravenously and following oral dosing phenobarbital is completely absorbed. In infants, seizures are controlled by an intravenous loading dose of 20 mg/kg followed by a maintenance dose of 4 mg/kg once-daily. In children, the treatment of all forms of epilepsy, except for typical absence seizures, consists in an oral phenobarbital and the status epilepticus is treated with intravenous phenobarbital and treatments consist in a loading dose followed by a maintenance dose. Phenobarbital induces several CYPs, UGT1A1, and CYP2B and CYP3A genes. In newborns and children, the elimination half-life is 46.9 hours and the distribution volume is 0.49 L/kg. In children with severe falciparum malaria and convulsions, the distribution volume is 0.79 L/kg. The treatment and trials with phenobarbital have been studied and phenobarbital interacts with drugs. Phenobarbital is transported into the human brain where reaches therapeutic concentrations and phenobarbital freely crosses the human placenta. Following therapeutic treatment with phenobarbital to lactating women, the concentrations of phenobarbital in the breast-milk are few µg/ml suggesting that phenobarbital poorly migrates into the breast-milk. The aim of this study is to review the published data of phenobarbital dosing, pharmacokinetics, treatment, and trials in infants and children, and the phenobarbital metabolism, phenobarbital transport in the human brain, placental transfer of phenobarbital, and phenobarbital migration into the breast-milk.
Does Following the Spiritual Pathway Means Health?
Authors: Kuman Maria
Published: January 2025

The article is about the health of individuals, who chose to follow the spiritual path, which means they chose to love, forgive, and help others. Love is the strongest positive emotion, helping others also brings positive emotions (we feel good that we have done something good), and so does forgiveness. According to my measurements positive emotions increase the body energy and make it more balanced. Since perfect balance means perfect health, positive emotions make us healthier. If so, the people following the spiritual path (practicing love, helping others, and forgiving) will experience a lot of positive emotions, which will make them healthier. If Francis of Assisi suffered of psychosomatic entrancement that made him have in real the five wounds Jesus suffered on the cross, was because of too much concentration on the suffering of Jesus’ material body instead of concentration on Jesus’ spiritual teaching of loving, forgiving, and helping others. (Francis died of these five wounds two years later.)
Спрямованість тренувальних навантажень ударних мікроциклів кваліфікованих спортсменів, які спеціалізуються в легкоатлетичному багатоборстві
Authors: Адамчук Вадим , Пліхта Сергій , Касьянова Ганна
Published: January 2025

One of the tendencies of the modern system of training of multyathletes, which is realised in the construction of shock microcycles, is a desire for the maximum use of both quantitative and qualitative characteristics of the training process. Orientation to the maximum possible volume characteristics and intensity of training was characteristic of most systems of training of the strongest multyathletes in the 1980–90s. At present, this trend is being replaced by more effective approaches to all components of the training process. The reason for this is the realisation that heavy loads are effective only up to the point where the quality of the training process does not suffer and there is no risk of overwork.
The purpose of the article is to determine the orientation of training loads in shock microcycles in the training of qualified multyathletes.
Research material and methods. The research used the following methods of scientific research: analysis of scientific and methodical literature, pedagogical observation; timing of training work; pulsometry; methods of mathematical statistics.
Track and field athletes (n=10) took part in the study. Qualified athletes are candidates for masters of sports; master of spotting Athletes are 18–30 years old.
Results of the research. This article deals with the question of the orientation of training loads in shock microcycles during the training of multyathletes. Correct alternation of such loads with rest creates favourable conditions for stimulation of adaptation processes in the organism of multyathletes. The article also presents a programme of a 7-day impact microcycle of qualified multyathletes at the stage of direct preparation for competitions.
Conclusions. As a result of the research, it was found that at the stage of direct preparation for competitions, qualified multyathletes apply a standard model of a 7-day impact microcycle, of which the 1st, 3rd and 6th days are trainings with a big load, the 2nd and 5th days – trainings with an average load of different orientation, the 4th and 7th days are devoted to active rest and restorative measures with loads of different orientation in different periods of preparation.
METABOLOMIC ANALYSIS TO DETERMINE THE ANTIBACTERIAL BIOMARKERS OF CITRONELLA (Cymbopogon nardus L.) ESSENTIAL OIL AND EXTRACT
Authors: Sukandar Dede , Dasumiati Dasumiati , Sulaswatty Anny , Novrianto Jefry , Agustian Egi , Heryanto Rudi , Rohman Saeful
Published: January 2025

This study aims to find the biomarkers for antibacterial activity in Mahapengiri citronella grass (Cymbopogon nardus L.). They were determined by comparing the compounds contained between each sample of essential oil and extract thoroughly using a Gas Chromatography-Mass Spectrometry (GC-MS)-based metabolomic approach. Essential oil was obtained using hydrodistillation with and without sonication pre-treatment, and steam distillation. Citronella extract was obtained through maceration using n-hexane and ethyl acetate. The samples’ antibacterial activity was tested by the broth microdilution method against E. coli and S. aureus, chemical component analysis using GC-MS, and determination of biomarker compounds using MetaboAnalyst application. Principal Component Analysis successfully differentiates essential oils and extracts into three groups based on their compound similarity, namely hydrodistillation, steam distillation, and extracts. Based on Orthogonal Partial Least Squares-Discriminant Analysis, the biomarkers of citronella essential oil that have potential as antibacterial agents were citronellal, citronellol, geraniol, and limonene; while the potential biomarkers in the extract were ethylbenzene, bis(2-ethylhexyl) phthalate, and geranyl acetate.
The Analysis of Blood Lead (Plumbum, Pb) Levels and Its Erythrocyte Morphology in Active Smokers
Authors: Marisa Marisa , Primal Def , Rosita Betti
Published: January 2025

Cigarettes are categorized as addictive substances with the highest toxicity to body’s tissues, resulting the hazardous complications in individuals and public health. It contains dangerous chemicals substances, such as carbon monoxide, nicotine, tar, ammonia, arsenic, cyanide, and lead (Pb). The main effect of these exposure, especially for the lead, is the intoxication of pulmonary tissues and decreasing of alveolar function through inhalation processes of smokers. It was reported at least 90% of these chemicals absorbed into the blood-streams and directly binds to erythrocyte and straightway disturbing the process of hemoglobin synthesis. This study analyzed the levels of lead (Pb) and erythrocyte morphology in active smokers among Motor Vehicle Weighing Implementation division (UPPKB) employees, in Kupang City. An analytic observational research method was obtained with cross-sectional design. We involved 15 respondents aged 20-40 years old with purposive sampling technique. Thereafter, beside the samples anamnesis had been examined, the blood sample were collected to analyze the erythrocyte morphology identifications with blood- smear analysis and the lead measurement with Atomic Absorption Spectrophotometer (AAS). From the research findings, lead (Pb) levels in active smoker’s blood were identified have an abnormal level above threshold of 14 samples (93%), with the highest one was 58μg/dL. On erythrocyte morphology examination, it reveals most of the erythrocytes' size was macrocytic (80%), deformities (80%), basophilic stippling (20%), while all erythrocytes showed normochromic color. We believed that lead accumulation in blood positively affect the erythrocyte quality and its function, and the prohibition of the cigarette circumgyration should be emphasized.
Proximate Analysis and Comparison of High Fiber Cookies Texture
Authors: Sari Elfira Maya , Fadhilah Tri Marta , Amalia Nofria Rizki
Published: January 2025

Indonesia is a country that has a variety of local ingredients that can be processed into flour as an alternative to wheat flour. The use of flour in Indonesia by the food processing industry includes ingredients for making foods such as cookies. The quality of food depends on the amount of nutrients it contains. This study involves cookie products processed from basic ingredients like wheat flour, mocaf flour, millet flour, psyllium husk flour, and three mixed formulas without wheat flour. To determine the nutrient content of a food, a proximate analysis is needed for cookies made with high-fiber flour. The examination methods used are the SNI 01-2891-1992 method and the SNI 2973:2011 method. The results show differences in proximate analysis between wheat flour cookies, mocaf flour, millet flour, psyllium husk flour, and the three mixed formulas. The proximate analysis of the cookies was compared with the SNI 01-2973-1992 standard. According to the nutritional analysis, the cookie products with treatments F1, F2, and F3, which have the highest carbohydrate and protein content and the lowest fat, are product F2. However, when considering crispiness, product F1 is the best because it has the lowest moisture and ash content, meeting the cookie standards.
STRATEGI PENINGKATAN KUALITAS PELAYANAN TERMINAL BUS ARJOSARI KOTA MALANG
Authors: Primasworo Rifky Aldila , Blima Oktaviastuti  , Retang Mus Mulyadi
Published: January 2025

Terminal Bus di Terminal Arjosari merupakan terminal penumpang tipe A di Kota Malang. Dalam perbaikan sistem transportasi khususnya di terminal, salah satu aspek yang penting diperhatikan adalah kualitas pelayanan pada sarana dan prasarananya. Kerap kali aspek kualitas pelayanan berupa ketentraman, keselamatan, ketertiban, aksesibilitas/kemudahan dan kesamaan diabaikan,  membuat  pengguna jasa terminal merasa tidak terbantu oleh  pengelola tertentu sehingga enggan menggunakan angkutan umum untuk mencapai tujuan yang ingin dicapai. Tujuan penelitian ini adalah untuk mengetahui persepsi penumpang terhadap kualitas pelayanan pada Terminal Bus di Terminal Arjosari Kota Malang saat ini. Adapun metode analisis menggunakan metode IPA. Berdasarkan hasil analisis IPA tingkat kesesuaian total antara tingkat kepuasan dan tingkat kepentingan sebesar 77,01%, yang artinya tingkat kepuasan dan tingkat kepentingan dari kualitas pelayanan yang telah diberikan oleh pihak pengelola terminal memuaskan/baik. Dari 35 atribut kuesioner terdapat 8 atribut yang masuk dalam kuadran I (prioritas utama), atribut tersebut sangat penting namun kinerjanya belum memuaskan. Kedelapan atribut tersebut yang masuk kuadran I yaitu : Pos, fasilitas dan petugas pemeriksaan kelaikan kendaraan umum, Informasi fasilitas keselamatan jalan, Informasi fasilitas kesehatan, Fasilitas keamanan, Toilet, Informasi gangguan perjalanan mobil bus, Fasilitas penyandang cacat (difabel) dan Ruang ibu menyusui.
Source-Free Semantic Regularization Learning for Semi-Supervised Domain Adaptation
Authors: Huang Xinyang
Published: January 2025

Semi-supervised domain adaptation (SSDA) has been extensively researched due to its ability to improve classification performance and generalization ability of models by using a small amount of labeled data on the target domain. However, existing methods cannot effectively adapt to the target domain due to difficulty in fully learning rich and complex target semantic information and relationships. In this paper, we propose a novel SSDA learning framework called semantic regularization learning (SERL), which captures the target semantic information from multiple perspectives of regularization learning to achieve adaptive fine-tuning of the source pre-trained model on the target domain. SERL includes three robust semantic regularization techniques. Firstly, semantic probability contrastive regularization (SPCR) helps the model learn more discriminative feature representations from a probabilistic perspective, using semantic information on the target domain to understand the similarities and differences between samples. Additionally, adaptive weights in SPCR can help the model learn the semantic distribution correctly through the probabilities of different samples. To further comprehensively understand the target semantic distribution, we introduce hard-sample mixup regularization (HMR), which uses easy samples as guidance to mine the latent target knowledge contained in hard samples, thereby learning more complete and complex target semantic knowledge. Finally, target prediction regularization (TPR) regularizes the target predictions of the model by maximizing the correlation between the current prediction and the past learned objective, thereby mitigating the misleading of semantic information caused by erroneous pseudo-labels. Extensive experiments on three benchmark datasets demonstrate that our SERL method achieves state-of-the-art performance.