bluuebunny/crossref_metadata_2025 huggingface dataset:
MANAGING THE ORGANISATION IN THE CONTEXT OF DIGITAL TRANSFORMATION
Authors:   Higher School of Industrial Policy and Entrepreneurship, Peoples’ Friendship University of Russia (RUDN University), Moscow, Russia, Ovchinnikova Oksana P. , Ostrovskaya Anna A. ,   Higher School of Industrial Policy and Entrepreneurship, Peoples’ Friendship University of Russia (RUDN University), Moscow, Russia, Tyulin Аndrey E. ,   Military-Industrial Commission of the Russian Federation, Moscow, Russia
Published: December 2023

In today's environment, the most well-known concept is digital transformation, which essentially means digital change of all processes, products, systems in an organisation. All processes are subject to change, because the introduction of digital technologies changes the entire economic space of the organisation. For example, product customers have high demands on product quality. Only the introduction of embedded quality in all production processes, which is ensured through automated control and the introduction of digital twins – a prototype of a product, process or system that can solve serious problems in adjusting product quality in real time – can satisfy this approach at low cost. The authors emphasise the need for digital transformation and implementation of digital twins for high-tech products with unique characteristics. The article highlights the directions of digital transformation implementation that are applicable to high-tech industries.
SPECIFICS, TRENDS AND PROSPECTS OF DEVELOPMENT OF TRANSNATIONAL CORPORATIONS
Authors:   Plekhanov Russian University of Economics, Moscow, Russian Federation, Balakhanova Dariko K. , Kozlov Vyacheslav A. ,   Plekhanov Russian University of Economics, Moscow, Russian Federation, Kuznetsov Pavel V. ,   Plekhanov Russian University of Economics, Moscow, Russian Federation, Chudnaya Anastasia D. ,   Plekhanov Russian University of Economics, Moscow, Russian Federation, An Bui Ngok ,   Plekhanov Russian University of Economics, Moscow, Russian Federation
Published: December 2023

The purpose of the article is to identify features in the organizational design of transnational corporations, which includes an analysis of their geographical location, and, accordingly, spheres of influence, emerging problems associated with their numerical increase. The analysis methodology is based on the principles of system analysis using a graphical method, and synthesis is also used to describe the specifics of the work of transnational corporations. When analyzing the dynamics of world economic processes, transnational corporations and national economic systems currently act as various objects of research.
QUALITY ASSURANCE OF FINANCIAL LITERACY IN THE CONTEXT OF NEW ECONOMIC CHALLENGES
Authors:   St. Petersburg State University of Economics, St. Petersburg, Russia, Bonyushko Natalya A. , Semchenko Anzhelika A. ,   St. Petersburg State University of Economics, St. Petersburg, Russia
Published: December 2023

The authors conduct a study of the current state of financial literacy quality management in the context of new economic challenges in the domestic economy, analyze the concept of financial literacy of the population, provide the opinions of experts in the national macroeconomic system, and analyze measures aimed at increasing financial literacy and the efficiency of the organization and the industry as a whole. The authors dwell in detail on the analysis of the main modern problems in the development of financial literacy, not only at the macroeconomic level, but also at the level of organizations, as well as the financial literacy of the population, and offer specific solutions and directions for further improving public policy in this area.
ACHIEVING FINANCIAL SOVEREIGNTY OF RUSSIA: ANALYSIS OF THE SITUATION AND STRENGTHENING DIRECTIONS FORMATION
Authors:   St. Petersburg University of Management Technologies and Economics, St. Petersburg, Russia, Bezgacheva Olga L. ,   Pushkin Leningrad State University, St. Petersburg, Russia, Rumyantseva Anna Yu. ,   St. Petersburg University of Management Technologies and Economics, St. Petersburg, Russia
Published: December 2023

The goal of the article is to assess the state of achieving financial sovereignty in Russia and formulate a list of key areas for strengthening financial independence and financial sovereignty. Financial sovereignty is the ability of a state to pursue independent domestic and foreign financial policies. It is ensured by financial security at all levels of management and in all spheres of socio-economic life. This article defines the differences between the concepts of financial independence and financial sovereignty. The level of financial sovereignty is analyzed and directions for strengthening financial independence and financial sovereignty are formed. The key factors for strengthening financial sovereignty include strengthening financial independence within the country and solving problems to strengthen financial sovereignty on the world stage. To strengthen financial sovereignty, it is necessary to take into account the variety of factors influencing it. It is necessary to continue work to strengthen financial independence within the country and financial sovereignty on the world stage, to complete the formation of regional financial centers that allow their member countries to pursue an independent financial policy; completion of the search for new forms of payment in international trade (creation of an accounting and settlement currency independent of the dollar and euro), to develop a mechanism that allows finding a balance between the financial sovereignty of countries included in new regional blocs and the degree of its limitation, taking into account the negative experience of the European Union.
BASIC PRINCIPLES AND COMPONENTS OF DIGITAL MARKETING
Authors:   Saint-Petersburg State University of Aerospace Instrumentation, St. Petersburg, Russia, Molchanova Regina V.
Published: December 2023

The article discusses the issues of digitalization of marketing strategies, allowing you to effectively interact with the target audience, improve business processes with the active implementation of modern technologies and tools. The justification for the relevance and practical significance of the research topic is due to changes in the digital environment and consumer behavior, expansion of geographic markets, increased efficiency of interaction with customers, reduced operating costs and increased transparency and analytics. It is emphasized that companies that effectively use digital marketing increase their market presence and improve customer focus. The author reveals in detail the economic aspects of studying digital audiences, emphasizing the increasing role of detailed segmentation in identifying effective marketing channels and methods that lead to increased return on investment in marketing and scaling. The article presents in tabular form the relationship of economic components, their role in digitalization and impact on the activities of the enterprise, as well as key methods for assessing the effectiveness of digital marketing campaigns. The challenges and problems of digital marketing related to data confidentiality, security issues, potential threats to business, the risk of data leakage and possible cyber attacks are identified. The influence of factors of increased competition, advertising efficiency, expansion of the geographical segment and target audience, affecting the financial performance of the enterprise, is noted. The effectiveness of the implementation and application of digital marketing strategies is summarized as a key competitive advantage for companies in the modern digital economy.
A SPECIAL ROLE OF REINSURANCE IN THE SYSTEM OF FINANCIAL RELATIONS OF THE INSURER
Authors:   Monns Organization, Tashkent, Uzbekistan, Umarov Khasan S. , Saveliev Alexey A. ,   Credendo – Ingosstrakh Credit Insurance, Moscow, Russia
Published: December 2023

The article analyzes the role of the reinsurance instrument in the insurer's activity and its influence on strengthening the risk management system, ensuring solvency and economic stability, as well as increasing the overall competitiveness of the insurer in various markets. It is noted that cooperation with reinsurers gives not only direct protection of insurer's business and its balance sheet indicators, but also provides growth of client base and opportunities to develop those standards of corporate governance, which contribute to the formation of stable and high business reputation of the insurer.
ANALYSIS OF THE STATE OF THE SUPPLEMENTARY EDUCATION MARKET IN RUSSIA
Authors:   St. Petersburg University of Management Technologies and Economics, St. Petersburg, Russia, Alexandrov Sergey Yu. , Slanov Valery P. ,   St. Petersburg University of Management Technologies and Economics, St. Petersburg, Russia, Shakurov Andrey A. ,   Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia
Published: December 2023

The state of the supplementary education market is considered, the influence of macroeconomic factors on the supply and demand side is analyzed, and the prospects for the development of educational activities are assessed. In general, the market is assessed as promising with favorable macro-environment factors. The concept of continuing education is shared by all market participants. The number of enterprises providing educational services continues to grow in the industry, including due to the absence of entrance barriers.
PROJECT APPROACH TO MARKETING ACTIVITY MANAGEMENT
Authors:   State University of Management, Moscow, Russia, Steblyakova Larisa P. , Aleshnikova Vera I. ,   State University of Management, Moscow, Russia, Petrenko Elena S. ,   Russian University of Economics named after G. V. Plekhanov, Moscow, Russia
Published: December 2023

The article is devoted to the development of the theory and practice of the project approach to the management of marketing activities of the organization, optimizing marketing efforts, increasing the effectiveness of marketing activities and ensuring the competitiveness of the company in the market. The definition of a marketing project was formulated as a result of recognition of its independence, as well as considering the features of the functional marketing component and the provisions of project management. The study of the methodology of the marketing project allowed us to identify its main stages, the specifics of the effectiveness assessment. The features of the development and implementation of the marketing project were demonstrated by the example of the promotion of a platform product to the market of knowledge management systems.
RELATIONSHIP MARKETING IN THE HIGHER EDUCATION SYSTEM
Authors:   St. Petersburg University of Management Technologies and Economics, St. Petersburg, Russia, Slanov Valery P. , Shakurov Andrey A. ,   Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia, Panchenko Ivan V. ,   Bank Saint Petersburg, Saint Petersburg, Russia
Published: December 2023

This article is devoted to the role of relationship marketing in the higher education system. The ongoing reforms, the development of technologies and the emergence of artificial intelligence dictated the conditions for changes in the field of education, which in turn led to the emergence of new approaches to marketing and managing relationships with consumers and partners. The article outlines the basic principles of the modern concept of relationship marketing. The possibilities and problems faced by universities in the context of digitalization are considered and analyzed.
QUALITY OF ELECTRONIC GOVERNMENT SERVICES: PROBLEM, APPROACHES TO ASSESSMENT AND MEASURES
Authors:   Kazan National Research Technical University named after A. N. Tupolev – KAI, Kazan, Russia, Nikolaeva Anna B. , Chugunov Kirill V. ,   Kazan National Research Technical University named after A. N. Tupolev – KAI, Kazan, Russia, Yudina Svetlana V. ,   Kazan National Research Technical University named after A. N. Tupolev – KAI, Kazan, Russia
Published: December 2023

Assessing the quality of public services in electronic form in Russia is carried out by the state represented by the Federal State Statistics Service, the Ministry of Digital Development, Communications and Mass Communications and state development institutions, as well as a wide expert community represented by university research teams and rating agencies. All the many methods used indicate that the quality of electronic government services (EGS) can be assessed using various approaches and criteria, which do not always confirm each other’s results. The study, the results of which are presented in these materials, compared conclusions drawn from the interpretation of open data on the e-Government Development Index (EGDI), as well as those obtained on the basis of European statistics, Russian state statistics, VСIOM data and data from independent web analytical services. The study showed that international experts from a special UN department rank the Russian Federation in the seventh ten countries in terms of EGS quality (above average rank), while national government agencies, while monitoring the use of EGS over the past years, have recorded a consistently high and growing level. Awareness and satisfaction with the quality of EGS among the Russian population is confirmed by independent web analytics data on traffic and its quality characteristics (depth and time) of the main state online service.
Surgical implantation of malignant cells: A review of evidence from 1850 to present day
Authors: Vidyarthi Ajay , Ranjan Kunal , Singh Pritesh Rajeev , Khemka Shruti , Venkataramu Vinay
Published: December 2023

Malignant cells, due to decreased cohesion between them, are more likely to exfoliate and implant at distant sites during manipulation. This concern was first expressed by A.G. Gerster in 1885. In this review, we undertook a comprehensive search of the literature to find the evidence for or against the iatrogenic implantation of cancer cells. An exhaustive search on PubMed, Medline, Embase, Science Direct, and Google Scholar yielded 215 relevant publications. The evidence presented in these publications was extracted and synthesized to draw conclusions for this review. Diagnostic and therapeutic procedures through fine/wide bore needles have demonstrated malignant cells in the needle tract but the incidence of recurrences ranges from 0.0003% to 0.9%. There is evidence of malignant cells adhering to surgical instruments, and some reports showed that the number cells needed for successful implantation is 106 – 107 cells in porcine models. A recent prospective study on colorectal malignancies has shown that the presence of intraperitoneal cells reduced 2-year survival but was not an independent predictor of the outcome. Port site recurrences have been documented since 1978 but the current consensus is more inclined to supporting the improper manipulation of tumor, rather than the laparoscopic procedure itself, as the inducer of port site recurrences. Intraperitoneal morcellation of leiomyomas and leiomyosarcomas does cause intra-peritoneal dissemination of tumor cells. Finally, many approaches to preventing implantation have been explored but lavage of operative site with distilled water may stand as the most promising strategy.
HUBUNGAN POLA ASUH ORANG TUA DENGAN SIBLING RIVALRY PADA ANAK BALITA
Authors: Hidayatin Titin , Purbasary Eleni Kenanga , Innayah Elsa Ainun
Published: December 2023

Pendahuluan: Pola asuh orang tua merupakan salah satu faktor yang mempengaruhi Sibling rivalry pada anak. Sibling rivalry merupakan persaingan atau pertengkaran antara saudara kandung (kakak atau adik). Sibling rivalry terjadi karena anak merasa takut kehilangan kasih sayang dan perhatian dari kedua orang tua. Tujuan penelitian adalah untuk mengetahui hubungan pola asuh orang tua dengan kejadian sibling rivalry pada anak balita. Metode: Penelitian menggunakan metode systematic literature review. Artikel diambil dari Portal Garuda, Google Scholar, ResearchGate dan OneSearch dari tahun 2011 s.d 2021. Prosedur pencarian dan seleksi artikel menggunakan Preferred Reporting Items for Systematic Reviews & Meta-analysis (PRISMA). Hasil: berdasarkan 5 artikel diketahui terdapat hubungan antara pola asuh orang tua dengan kejadian sibling rivalry pada anak balita, dengan nilai p value < 0,05. Kesimpulan: Pada penelitian ini adalah pola asuh demokratis banyak dipilih oleh orang tua untuk meminimalkan terjadinya sibling rivalry pada anak. Saran ditujukan untuk perawat agar dapat mengaplikasikan dengan memberikan penyuluhan kepada orang tua mengenai pentingnya menerapkan pola asuh yang sesuai agar tidak terjadi sibling rivalry.

 

Kata kunci                 : Pola asuh orang tua, Sibling rivalry.
PENGARUH PERAN ORANG TUA DAN POLA ASUH ORANG TUA TERHADAP HASIL BELAJAR SISWA SDN CIPUTAT
Authors: Nurrahmah Ghina , Nana Hendra Cipta  , Siti Rokmanah
Published: December 2023

This research has a main focus with the aim of determining the influence of parental role variables and parenting patterns on the learning outcomes of Ciputat State Elementary School students. The research was prepared using a quantitative method approach. Conducted using a research sample of 3rd grade students at Ciputat State Elementary School. The research sample was obtained by random sampling. Data was obtained by collecting it using a questionnaire or questionnaire which was prepared using a technique using a Likert scale. The research results were carried out with descriptive tests, normality tests with Kolmogorov Smirnov linearity tests, multicollinearity tests and heteroscedasticity tests. To determine the influence between variables, a multiple regression test was carried out using the t test with a significance level of 0.05. The research results show that the majority of parents are in the very strong parental role category with a percentage of 52.2%, the majority apply democratic and accepting parenting with a percentage of 87.0% and the majority of student learning outcomes are in the very good category 65.2% . The results of the multiple regression t test showed a significance result of 0.000<0.05 on the variable of the role of parents on student learning outcomes, so it can be seen that the role of parents has an influence on student learning outcomes. For the parenting pattern variable, the results obtained at a significance level of 0.001<0.05, so it is also known that parental parenting influences or influences student learning outcomes.

Keywords: learning outcome, parenting style, elementary school students
Designing an Efficient Restaurant Recommendation System Based on Customer Review Comments by Augmenting Hybrid Filtering Techniques
Authors: Mauparna Nandan  , Pourush Kumar Gupta
Published: December 2023

Recommendation systems are being widely employed in order to provide users with a tailored set of services. They are primarily designed to generate advice or ideas (like restaurants, tourist places, medicines, movies, etc.) that address user concerns and can be efficiently utilized in a variety of industries. In today’s world, where we have a plethora of dining options available, choosing the right restaurant that matches our preferences can be a daunting task. To simplify this process and provide personalized recommendations, restaurant recommendation systems have emerged as a valuable tool. By leveraging the power of natural language processing (NLP), these systems can analyze textual data, such as user reviews and restaurant descriptions, to generate tailored suggestions for users. NLP is one of the machine learning techniques for intelligently and effectively analyzing, comprehending, and extracting meaning from human language. By utilizing techniques like sentiment analysis and named entity recognition, the system can understand user queries and match them with relevant restaurant attributes. It can consider factors such as cuisine type, price range, location, ambiance, and customer reviews to generate accurate and relevant recommendations. In the current study, the evaluation’s findings reveal that the suggested ExtraTreeRegressor algorithm outperforms other algorithms in terms of performance. The novelty of this research lies in the fact that here hybrid filtering is employed, which is not yet implemented in similar studies. The goal of this research article is to provide a more accurate and reachable list of suggested eateries. The results and conclusion show that the suggested approach produces good accuracy.
Literārās valodas un sarunvalodas attiecības: sociālo mediju piemērs
Authors:   Liepaja University, Lauze Linda , Mežapuķe Kristīne ,   University of Latvia. Latvian Language Institute
Published: December 2023

The case of social media demonstrates the growing relevance of the relationship between literary language and colloquial speech in today’s society. The article encourages us to think: is it really no longer important to switch linguistic codes based on the nature of the speech situation when the choice of language means is applied, and one or the other type of language existence is used; is communication more and more dominated by colloquial speech? The study aims to characterise the interaction and competition between literary and colloquial language in the use of the Latvian language by analysing examples of social media and their use. The research material is Twitter posts on the social networking site, texts published on various Internet portals and recorded on television and radio, and an express survey in which 425 respondents took part. Descriptive method, content analysis and survey were used. The article analyses the understanding of literary language and colloquial language. For many years, Jānis Rozenbergs’s definition of the literary language has been valid in Latvian linguistics. However, the definition was created when social media did not have the same influence as today and when the words of writers, poets and other cultural figures still had great power. The opinion that literary language and colloquial speech are two separate types of language existence is supported. Journalists’ communicative competence plays an important role in observing the conditional distinction between public and private communication in language practice. The results of the express survey confirm that the majority of respondents (44%) attach the main importance to the genre of the programme and not to the fact that a journalist should choose a literary language when speaking in public. Posts on social networking sites are widely quoted and retold on other social media, radio and television, and even relatively official news programmes. It can be concluded that the use of colloquial speech continues to expand under the influence of social media.
Ģenitīva prievārdu rekcijas īpatnības lībiskā dialekta Kurzemes izloksnēs
Authors:   University of Latvia. Latvian Language Institute, Ozola Anete
Published: December 2023

The government of prepositions in modern Latvian literary language has strict norms depending on various factors: preposition, number, gender, meaning, etc. However, the system of preposition government is different and inconsistent in Kurzeme Livonic subdialects. Older sources of Latvian written language and Latvian grammar also point to an unstable government. Until now, in Latvian dialectology, researchers have repeatedly pointed out that the use of genitive preposition with the governed word in the accusative case can be called a traditional feature of Livonic dialect, but it is often impossible to determine a clear grammatical case because of the reduction of the vowel of last syllable, so sometimes the accusative and genitive forms are identical. The aim of the article is to consider and map the preposition uz, pie, pēc and no government in all Kurzeme subdialects of Livonic dialect, where the governed words are singular. The descriptive method and cartography method that describes and compares prepositions and their government are used in the article.
EDUCATIONAL EVENT AS A MEANS OF CHANGING THE PERSONAL POTENTIAL OF PEDAGOGICAL UNIVERSITY STUDENTS
Authors:   Ural State Pedagogical University, Yezhov Pavel Yu. , Novikova Olga V. ,   Ural State Pedagogical University
Published: December 2023

The priority task of modern education is the development of the student’s ability to self-regulate, create and live his own life, which is the essence of personal potential. One of the promising areas is event-based pedagogy (Event-based learning). This approach has shown effectiveness in the pedagogical process and aroused great interest in many countries. The paper presents the development and implementation of an educational event that helps to increase the student’s personal potential, and provides recommendations for creating such an event.
MEANINGFUL LIFE ORIENTATIONS AND MOTIVATION OF STUDENTS’ LEARNING ACTIVITIES
Authors:   Altai State Pedagogical University, Darvish Olesya B. , Kholodkova Olga G. ,   Altai State Pedagogical University
Published: December 2023

The paper presents a study of the relationship between meaningful life orientations and learning motives of students at the pedagogical university. The relevance of the study of life-meaning orientations and motives of the teaching of modern students is determined. Approaches to understanding the motivation of learning are analyzed, the essence of meaningful life orientations and the features of their formation during the student period are determined. Differences in the severity of learning motives, the specifics of meaningful life orientations among students of the 1st and 4th courses are described. Comparative results of the study of the relationship between meaningful life orientations and learning motives among 1st and 4th year students are presented.
DYNAMICS OF INDICATORS OF DEVELOPMENT OF MOTIVATIONAL AND VOLUNTARY SPHERES DURING PRESCHOOL CHILDHOOD
Authors:   Kemerovo State University, Lapteva Yulia A.
Published: December 2023

The article presents the theoretical rationale and results of empirical research on a sample of children from 4 to 7 years old (n = 303). It is established that the dynamics of indicators can be rightly considered through the assessment of cognitive choice, motives of self-affirmation and establishment and preservation of positive relationships with adults and peers, arbitrariness of actions and cognitive activity, ability to perform actions in accordance with instructions. The differences of parameters and content characteristics of indicators are revealed.
Gut microbiota in women: The secret of psychological and physical well-being
Authors: Marano Giuseppe , Traversi Gianandrea , Gaetani Eleonora , Gasbarrini Antonio , Mazza Marianna
Published: December 2023

The gut microbiota works in unison with the host, promoting its health. In particular, it has been shown to exert protective, metabolic and structural functions. Recent evidence has revealed the influence of the gut microbiota on other organs such as the central nervous system, cardiovascular and the endocrine-metabolic systems and the digestive system. The study of the gut microbiota is outlining new and broader frontiers every day and holds enormous innovation potential for the medical and pharmaceutical fields. Prevention and treatment of specific women’s diseases involves the need to deepen the function of the gut as a junction organ where certain positive bacteria can be very beneficial to health. The gut microbiota is unique and dynamic at the same time, subject to external factors that can change it, and is capable of modulating itself at different stages of a woman’s life, playing an important role that arises from the intertwining of biological mechanisms between the microbiota and the female genital system. The gut microbiota could play a key role in personalized medicine.
Association of low muscle strength with metabolic dysfunction-associated fatty liver disease: A nationwide study
Authors: Lee Gyu Bae , Huh Youn , Lee Sang Hyun , Han Byoungduck , Kim Yang-Hyun , Kim Do-Hoon , Kim Seon Mee , Choi Youn Seon , Cho Kyung Hwan , Nam Ga Eun
Published: December 2023

BACKGROUND

There is limited evidence regarding the association between muscle strength and metabolic dysfunction-associated fatty liver disease (MAFLD).

AIM

To investigate the association between muscle strength and MAFLD in the general population in Korea.

METHODS

This nationwide representative cross-sectional study included 31649 individuals aged ≥ 19 years who participated in the Korea National Health and Nutrition Examination Survey between 2015 and 2018. Odds ratios (ORs) and 95% confidence intervals (95%CIs) for MAFLD according to sex-specific quartiles of muscle strength, defined by relative handgrip strength, were calculated using multivariable logistic regression analysis. Additionally, multivariable logistic regression analysis was used to assess the association between muscle strength and probable liver fibrosis in patients with MAFLD.

RESULTS

Of all the participants, 29.3% had MAFLD. The prevalence of MAFLD was significantly higher in the lower muscle strength quartile groups for all participants, sexes, and age groups (P < 0.001). A 1.92-fold (OR = 1.92, 95%CI: 1.70–2.16) and 3.12-fold (OR = 3.12, 95%CI: 2.64–3.69) higher risk of MAFLD was observed in the lowest quartile (Q1) group than in the other groups (Q2–Q4) and the highest quartile (Q4) group, respectively. The ORs of MAFLD were significantly increased in the lower muscle strength quartile groups in a dose-dependent manner (P for trend < 0.001). These associations persisted in both sexes. An inverse association between muscle strength and the risk of MAFLD was observed in all subgroups according to age, obesity, and diabetes mellitus. In patients with MAFLD, the odds of severe liver fibrosis were higher in Q1 (OR = 1.83, 95%CI: 1.25–2.69) than in other groups (Q2–Q4).

CONCLUSION

Among Korean adults, low muscle strength was associated with an increased risk of MAFLD and liver fibrosis in patients with MAFLD.
Thioridazine reverses trastuzumab resistance in gastric cancer by inhibiting S-phase kinase associated protein 2-mediated aerobic glycolysis
Authors: Yang Zheng-Yan , Zhao Yi-Wei , Xue Jing-Rui , Guo Ran , Zhao Zhi , Liu Han-Di , Ren Zhi-Guang , Shi Ming
Published: December 2023

BACKGROUND

Trastuzumab constitutes the fundamental component of initial therapy for patients with advanced human epidermal growth factor receptor 2 (HER-2)-positive gastric cancer (GC). However, the efficacy of this treatment is hindered by substantial challenges associated with both primary and acquired drug resistance. While S-phase kinase associated protein 2 (Skp2) overexpression has been implicated in the malignant progression of GC, its role in regulating trastuzumab resistance in this context remains uncertain. Despite the numerous studies investigating Skp2 inhibitors among small molecule compounds and natural products, there has been a lack of successful commercialization of drugs specifically targeting Skp2.

AIM

To discover a Skp2 blocker among currently available medications and develop a therapeutic strategy for HER2-positive GC patients who have experienced progression following trastuzumab-based treatment.

METHODS

Skp2 exogenous overexpression plasmids and small interfering RNA vectors were utilized to investigate the correlation between Skp2 expression and trastuzumab resistance in GC cells. Q-PCR, western blot, and immunohistochemical analyses were conducted to evaluate the regulatory effect of thioridazine on Skp2 expression. A cell counting kit-8 assay, flow cytometry, a amplex red glucose/glucose oxidase assay kit, and a lactate assay kit were utilized to measure the proliferation, apoptosis, and glycolytic activity of GC cells in vitro. A xenograft model established with human GC in nude mice was used to assess thioridazine's effectiveness in vivo .

RESULTS

The expression of Skp2 exhibited a negative correlation with the sensitivity of HER2-positive GC cells to trastuzumab. Thioridazine demonstrated the ability to directly bind to Skp2, resulting in a reduction in Skp2 expression at both the transcriptional and translational levels. Moreover, thioridazine effectively inhibited cell proliferation, exhibited antiapoptotic properties, and decreased the glucose uptake rate and lactate production by suppressing Skp2/protein kinase B/mammalian target of rapamycin/glucose transporter type 1 signaling pathways. The combination of thioridazine with either trastuzumab or lapatinib exhibited a more pronounced anticancer effect in vivo, surpassing the efficacy of either monotherapy.

CONCLUSION

Thioridazine demonstrates promising outcomes in preclinical GC models and offers a novel therapeutic approach for addressing trastuzumab resistance, particularly when used in conjunction with lapatinib. This compound has potential benefits for patients with Skp2-proficient tumors.
IMPACT OF SOCIAL MEDIA MARKETING, E-WOM, AND BRAND AMBASSADOR ON CONSUMER'S PURCHASE DECISION ON THE SKINCARE PRODUCT IN INDONESIA: BRAND IMAGE AS A MEDIATOR
Authors: Marliya Siti , Tafiprios
Published: December 2023

This research explores consumer behavior in the cosmetics market that tends to switch brands and how this behavior can affect brand image. In the context of skin care products in Indonesia, this study examines the impact of social media marketing, E-WOM (electronic word of mouth), and the role of brand ambassadors on purchasing decisions. In addition, this study investigates the mediating role of brand image in linking these digital marketing factors to consumer purchase intent. This research method is quantitative, namely a causal research design with a population of local skin care product users in Indonesia, sampling using guidelines where to determine the sample size in the study is five to ten times greater than the indicators used to measure each construct. A total of 367 respondents were collected through an online survey using purposive sampling techniques. Data analysis using the Partial Least Square (Smart-PLS) program. The results indicate that social media marketing, E-WOM and brand ambassadors have a direct impact on purchasing decisions, while social media marketing does not have a significant direct impact on brand image and not for e-WOM and brand ambassadors who are found to have a significant influence. Brand image has the strongest impact on purchase decisions and brand ambassadors have the strongest impact on brand image. The results also show that brand image acts as a mediator in influencing social media marketing on purchase intention with indirect only mediation, as well as influencing E-WOM, and brand ambassadors on purchase intention with partial mediation. These results provide a deeper understanding of consumer buying behavior in skin care products and the importance of brand image in the process.
La especialidad de Neumología. Antecedentes. Desarrollo asistencial y científico. Perspectivas futuras
Authors: Barrios Barreto Deisy , Jiménez David
Published: December 2023

El artículo ofrece un detallado análisis de la evolución histórica y la actualidad de la neumología en España. Se destaca la preocupación antigua por las enfermedades respiratorias, desde la antigua Grecia hasta la época romana, y cómo figuras como Hipócrates y Galeno contribuyeron a la comprensión de los problemas respiratorios. Durante la Edad Media y el Renacimiento, hubo avances significativos en el estudio de la anatomía y fisiología humanas, con figuras como Leonardo da Vinci. La llegada de la tuberculosis y la epidemia en el siglo XIX llevó a una mayor investigación y a la fundación de organizaciones para el estudio y prevención de esta enfermedad. La especialidad de neumología comenzó a evolucionar en la década de 1950, y se destacan importantes hitos como la creación de la Sociedad Torácica Americana y la Asociación Nacional para el Estudio y Prevención de la Tuberculosis. En España, la neumología se desarrolló a través de la especialización en el manejo de la tuberculosis. La especialidad fue reconocida oficialmente en 1978, establecido por un sistema de formación para residentes sistema MIR (Médico Interno Residente) enfocado en una sólida base en medicina interna y habilidades específicas en diagnóstico, tratamiento y prevención de enfermedades respiratorias. La neumología actual enfrenta desafíos importantes, como la prevención de enfermedades respiratorias mediante campañas educativas y la colaboración interdisciplinaria entre profesionales de la salud. La introducción de tecnologías avanzadas y tratamientos personalizados está transformando el diagnóstico y la medicina de precisión para el manejo de las enfermedades respiratorias dando forma al futuro de esta especialidad médica, que se encuentra en una posición central para ofrecer una atención óptima y accesible para todos.
Efektivitas Bahan Ajar IPA Topik Pencemaran Lingkungan Berbasis Nilai-Nilai Keislaman terhadap Hasil Belajar dan Karakter Religius Siswa
Authors: Emilda Prasiska  , Fitria Rizkiana
Published: December 2023

Bahan ajar merupakan salah satu media pembelajaran yang dapat membantu guru dalam memberikan informasi kepada peserta didik dimana memiliki peran dalam proses belajar di dalam kelas yakni mendukung tercapaiannya tujuan pembelajaran. Ketercapaian tujuan pembelajaran selama proses pembelajaran menjadi tolak ukur dalam mengukur keefektifan pembelajaran yang diberikan, dimana dapat dilihat dari hasil belajar yang diperoleh oleh peserta didik selama proses belajar. Guru juga harus mampu memberikan pemahaman dengan baik serta mampu menerapkan nilai-nilai pendidikan kepada peserta didik. Bahan ajar yang terintegrasi ayat-ayat Al-Qur’an menjadi salah satu cara untuk menanamkan nilai-nilai keislaman kepada siswa. Desain penelitian ini menggunakan quasi eksperimental design dengan rancangan nonquivalent control group design dimana desain atau rancangan ini terdiri dari dua kelas yaitu kelompok eksperimen (kelompok yang menggunakan bahan ajara IPA Topik Pencemaran Lingkungan berbasis nilai-nilai keislaman) dan kelas kontrol sebagai kelas pembanding yaitu menggunakan bahan ajar yang ada di sekolah. Data hasil penelitian menunjukkan bahwa terdapat perbedaan hasil belajar antara kelas ekperimen dan kelas kontrol dengan nilai sig (2-tailed) adalah 0,000 < 0,005. Data karakter religius dengan nilai rata-rata presentase skor yang diperoleh sebesar 75% dengan kategori baik. Berdasarkan hasil penelitian tersebut dapat disimpulkan bahwa Bahan Ajar IPA topik Pencemaran Lingkungan berbasis nilai- nilai keislaman efektif terhadap hasil belajar dan karakter religius siswa.
The Role of Internal Audit and Internal Control on the Quality of Financial Reports at PT. ABC
Authors: Mursyida Indah , Maulina Rina
Published: December 2023

The quality of financial reports is a measure of the extent to which a company's financial reports meet various characteristics and attributes that are considered important. In this research, the author uses a quantitative research approach. It has the systematic nature of field research. The types of data for this research are primary data and secondary data. The main data in this research was taken directly from distributing questionnaires to PT.  ABC. The population in this observation is all employees at PT. ABC as many as 125 people. The sample selection technique used in this research was a saturated sample or the entire population was sampled, namely 125 people. However, when distributing the questionnaire to 125 samples, only 120 people received answers, so only 120 samples were used in this research. The research results state that internal audit and internal control have a partial and simultaneous effect on the quality of financial reports.
THE LEGAL REGULATION OF ANTI-MINING ACTIVITIES: INTERNATIONAL EXPERIENCE
Authors: Plynokos D. , Davydenko L. , Shabanov D. , Kukurian О.
Published: December 2023

Ukraine is among the countries with the largest quantity victims from field mines and others explosive devices. That demands from state authorities to conduct measures related to search, detection and disposal explosive items on the contaminated (probably contaminated) territory of Ukraine, water areas and objects infrastructure. Comprehensive and effective solution of problems is possible only by creation effective organizational and legal systems humanitarian demining using best international experience which should become important component part of State Strategy of anti-mining activities.

The purpose of the article is to analyse the current state of legal regulation anti-mine activities in Ukraine and find out directions for implementation of international experience, in particular, the NATO member states, to create modern organizational and legal system of anti-mining activity in our the state.

During the research the general scientific and special methods were applied, in particular methods of system analysis and synthesis, comparative legal methods etc.

The analysis of current legislation anti-mining activities in Ukraine is done, the gaps and shortcomings of legal regulation are defined and directions of impact of international law on national standards using better international experience are formulated.
The special features of using the artificial intelligence in the matters of cybersecurity
Authors: HURZHII S.
Published: December 2023

The role and importance of artificial intelligence in the field of cyber security is determined. The methods of using artificial intelligence in cyber security are detailed. The advantages and priorities of the use of artificial intelligence in the sphere of cyber security are defined. The shortcomings and problematic issues related to the use of artificial intelligence technologies by hackers in the field of cyber security are summarized. The innovative achievements of the practical implementation of generative artificial intelligence technologies ChatGPT (Generative Pre-trained Transformer) are highlighted. The legal principles of the regulation of artificial intelligence in the field of cyber security in Ukraine are outlined. Threatening trends in the use of artificial intelligence technologies have been identified based on the Europol report 2023. A review of the legislative initiatives of the EU aimed at regulating the field of artificial intelligence, in particular in the issue of cyber security, was conducted. The directions of improvement of the legal framework and regulatory requirements regarding the use of artificial intelligence technologies in the field of cyber security are summarized, especially in the conditions of the legal regime of martial law in Ukraine.
A DEUSA PERSÉFONE COMO ARQUÉTIPO FEMININO SOMBRIO: UM BREVE ESTUDO
Authors: Costa Pamela Cristina Celentano , Mello Leonardo Tondato
Published: December 2023

Ao pensar em Coré-Perséfone, o que costuma vir à nossa mente? Num primeiro momento, talvez pensemos em sua vulnerabilidade e, portanto, numa jovem doce, ingênua e submissa, sempre junto à sua mãe e, posteriormente, ao seu marido. Neste trabalho, objetivo trazer a versão sombria da deusa Perséfone, que passa por diversos percalços em sua jornada rumo ao processo de individuação, realizando a passagem de um estágio de sua vida para outro e encontrando, através de sua dor e perda, uma nova identidade, mais autônoma e soberana de si.
CORPOREIDADE E ETARISMO
Authors: Zago Maria Cristina
Published: December 2023

O objetivo deste estudo é discutir o preconceito em relação aos indivíduos em idade adulta avançada. Trata-se de um estudo teórico que procura estabelecer uma interface entre as concepções psicanalíticas freudianas e as sociológicas, especialmente, as de David Lê Breton, em relação “a corporeidade”, a fim de se abordar o preconceito de idade como fenômeno cultural e social. O corpo é motivo simbólico e objeto de representações e imaginários. Nesse sentido, são atribuídos ao indivíduo diferentes rótulos de acordo com valores e crenças coletivas durante seu ciclo de vida. Enfatiza-se que a elaboração de termos como “melhor idade” constituem-se em sintomas sociais velados do processo de desvalorização dos indivíduos em idade avançada. Considera-se que defesas primitivas são acionadas para administrar ansiedades e inadequações relativas ao envelhecer: negação, evitação, divisão e identificações projetivas e introjetivas. Assim, o que é percebido como mal, feio, fraco e impotente caracterizam “o Grupo-Não Eu” (“The Not Me Group”), e neste caso, os “velhos”, enquanto o que é bom, saudável, bonito, poderoso caracteriza “o Grupo-Eu” (“The Me Group”), ou seja, os “jovens”. Expurgar do “eu grupal” as partes tidas como repugnantes e inaceitáveis para outro grupo acarreta inúmeros prejuízos para o existir individual e coletivo. Ressalta-se que a mídia atua no sentido de “organizar-manipular” a opinião pública. Assim, intervenções na tríade “pensar, sentir e agir” devem contar com os meios de comunicação para o estabelecimento de novas compreensões a respeito do processo de envelhecimento e em relação aos indivíduos em idade avançada.
APLICAÇÕES E POTENCIALIDADES DO ÓLEO ESSENCIAL DA HYPTIS SUAVEOLENS: UMA REVISÃO DE LITERATURA
Authors: Nunes Kaio Viníccius Zacarias , Leite Ricardo Henrique de Lima
Published: December 2023

Os óleos essenciais são substâncias voláteis extraídos de plantas aromáticas através de diversos métodos. No Brasil, ocorre uma abrangente extração e venda de óleos originados de plantas nativas e exóticas. A Hyptis suaveolens é uma planta nativa do continente americano e caracterizada por sua adaptabilidade a uma variedade de condições de cultivo, o que a torna uma excelente opção para exploração comercial. Assim, o propósito deste estudo consistiu em conduzir uma revisão bibliográfica abordando as propriedades biológicas do óleo essencial obtido da H. suaveolens. A metodologia adotada baseou-se na pesquisa de fontes bibliográficas, com ênfase na identificação das publicações mais relevantes entre o período de 2013 a 2023 e relacionadas ao tema em questão. O estudo demonstrou a possibilidade do uso de óleo essencial como uma alternativa sustentável para o controle de pragas e vetores.
FUSARIUM OXYSPORUM F. SP. TRACHEIPHILUM: ANTAGONISMO IN VITRO POR BACILLUS SPP. E REAÇÃO DE CULTIVARES DE FEIJÃO CAUPI SOB ADUBAÇÃO ORGÂNICA
Authors: Rodrigues Antonia Alice Costa , Barros Dianny Regina Silva , Silva Erlen Keila Candido e , Oliveira Leonardo de Jesus Machado Góis de , Dias Larisse Raquel Carvalho , Nascimento Ivaneide de Oliveira , Borba Maria Francisca Oliveira , Sousa Eliza Gonçalves de , Cunha Érica Louzeiro , Paz Dannielle Silva da
Published: December 2023

A murcha de Fusário causada pelo fungo Fusarium oxysporum f. sp. tracheiphilum, é uma das principais doenças que ocorrem na cultura do feijao caupi . Desta forma, o presente trabalho teve como objetivo avaliar o efeito antagônico in vitro mediado por isolados de Bacillus spp. sobre o F. oxysporum f. sp. thacheiphilum, e a resistência de cultivares de feijão caupi adubadas com esterco bovino. Na atividade antagonica foram utilizados os métodos de metabólitos termoestáveis e pareamento em círculo com avaliações do potencial antagonico realizadas, através de medições em dois sentidos diametralmente opostos. O teste de resistência foi realizado com as cultivares de Caupi BRS Aracê, BRS Pujante, BRS Guariba, BRS Tumucumaque, BR-17 Gurguéia e Manteiguinha. As cultivares foram adubadas com esterco bovino e as plantas inoculadas com o fitopatógeno. A avaliação ocorreu 21 dias após a inoculação utilizando-se escala de notas. Na avaliação do potencial de metabólitos termoestáveis, os cinco isolados de Bacillus testados demonstraram antagonismo ao F. oxysporum f. sp. tracheiphilum, produzindo metabolitos capazes de inibir o crescimento do patógeno. No método de pareamento em círculo constatou-se que todos os isolados de Bacillus apresentaram efeito inibidor sobre o crescimento micelial do fungo F. oxysporum f. sp. tracheiphilum. As cultivares BRS Aracê e BRS Pujante apresentaram maior resistência ao fitopatógeno. Desta forma, controle biológico por microrganismos e a identificação de variedades resistentes apresentam-se como alternativas para redução ou eliminação do uso de agroquímicos no controle de fitopatógeno.