bluuebunny/crossref_metadata_2025 huggingface dataset:
Mild Cognitive Impairment: the Manchester consensus
Authors: Dunne Ross A , Aarsland Dag , O’Brien John T , Ballard Clive , Banerjee Sube , Fox Nick C , Isaacs Jeremy D , Underwood Benjamin R , Perry Richard J , Chan Dennis , Dening Tom , Thomas Alan J , Schryer Jeffrey , Jones Anne-Marie , Evans Alison R , Alessi Charles , Coulthard Elizabeth J , Pickett James , Elton Peter , Jones Roy W , Mitchell Susan , Hooper Nigel , Kalafatis Chris , Rasmussen Jill G C , Martin Helen , Schott Jonathan M , Burns Alistair
Published: October 2020

Given considerable variation in diagnostic and therapeutic practice, there is a need for national guidance on the use of neuroimaging, fluid biomarkers, cognitive testing, follow-up and diagnostic terminology in mild cognitive impairment (MCI). MCI is a heterogenous clinical syndrome reflecting a change in cognitive function and deficits on neuropsychological testing but relatively intact activities of daily living. MCI is a risk state for further cognitive and functional decline with 5–15% of people developing dementia per year. However, ~50% remain stable at 5 years and in a minority, symptoms resolve over time. There is considerable debate about whether MCI is a useful clinical diagnosis, or whether the use of the term prevents proper inquiry (by history, examination and investigations) into underlying causes of cognitive symptoms, which can include prodromal neurodegenerative disease, other physical or psychiatric illness, or combinations thereof. Cognitive testing, neuroimaging and fluid biomarkers can improve the sensitivity and specificity of aetiological diagnosis, with growing evidence that these may also help guide prognosis. Diagnostic criteria allow for a diagnosis of Alzheimer’s disease to be made where MCI is accompanied by appropriate biomarker changes, but in practice, such biomarkers are not available in routine clinical practice in the UK. This would change if disease-modifying therapies became available and required a definitive diagnosis but would present major challenges to the National Health Service and similar health systems. Significantly increased investment would be required in training, infrastructure and provision of fluid biomarkers and neuroimaging. Statistical techniques combining markers may provide greater sensitivity and specificity than any single disease marker but their practical usefulness will depend on large-scale studies to ensure ecological validity and that multiple measures, e.g. both cognitive tests and biomarkers, are widely available for clinical use. To perform such large studies, we must increase research participation amongst those with MCI.
DeepSSV: detecting somatic small variants in paired tumor and normal sequencing data with convolutional neural network
Authors: Meng Jing , Victor Brandon , He Zhen , Liu Hongde , Jiang Taijiao
Published: October 2020

It is of considerable interest to detect somatic mutations in paired tumor and normal sequencing data. A number of callers that are based on statistical or machine learning approaches have been developed to detect somatic small variants. However, they take into consideration only limited information about the reference and potential variant allele in both tumor and normal samples at a candidate somatic site. Also, they differ in how biological and technological noises are addressed. Hence, they are expected to produce divergent outputs. To overcome the drawbacks of existing somatic callers, we develop a deep learning-based tool called DeepSSV, which employs a convolutional neural network (CNN) model to learn increasingly abstract feature representations from the raw data in higher feature layers. DeepSSV creates a spatially oriented representation of read alignments around the candidate somatic sites adapted for the convolutional architecture, which enables it to expand to effectively gather scattered evidence. Moreover, DeepSSV incorporates the mapping information of both reference allele-supporting and variant allele-supporting reads in the tumor and normal samples at a genomic site that are readily available in the pileup format file. Together, the CNN model can process the whole alignment information. Such representational richness allows the model to capture the dependencies in the sequence and identify context-based sequencing artifacts. We fitted the model on ground truth somatic mutations and did benchmarking experiments on simulated and real tumors. The benchmarking results demonstrate that DeepSSV outperforms its state-of-the-art competitors in overall F1 score.
Building Collaboration with Child Protection and Domestic and Family Violence Sectors: Trialling a Living Lab Approach
Authors: Wendt Sarah , Bastian Carmela , Jones Michelle
Published: October 2020

Collaboration across child protection and domestic and family violence (DFV) sectors have long been sought despite the competing priorities found in these practice fields. This article describes a research partnership that aimed to explore the competing priorities by focusing on how workers interact across child protection and DFV specialist agencies. Using a Living Lab Approach, enabled twelve focus groups with child protection and DFV social workers (n = 100). Thematic analysis was conducted, and it was found that diverse understandings of DFV created tensions when trying to form collaborations. These tensions were often amplified when other intersecting issues were present in family lives such as drug and alcohol and mental health problems. Understandings of Aboriginal cultural safety, and religious and culture impacts for cultural and linguistically diverse families were unintentionally sidelined. However, practitioners also formed common understandings of opportunities to progress and sustain collaboration across the sectors. The Living Lab Approach facilitated the development of a policy and practice guide for child protection to support future work. This has implications for social work practice because the Living Lab Approach enabled a call for a consistent approach to DFV that should be gender sensitive, trauma informed and culturally safe, and collaboration at practitioner, team and organisational levels.
Elevational Changes in Mormon Cricket Life Histories: Minimum Temperature for Nymphal Growth Declines With Elevation
Authors: Srygley Robert B
Published: October 2020

As the mean temperature and the duration of the growing season decline with elevation, growth of immature insects should initiate at a lower temperature, but it should also be faster to complete development prior to season’s end. Although flightless, Mormon crickets migrate in large aggregations across broad spatial and elevational distances that might limit adaptations to local environments. In addition, selection to be active at cooler temperatures might limit selection to maximize growth rate. I measured growth rate in controlled environments for nymphs from three populations that vary in altitude (87–2,688 m) but are similar in latitude (43.2–45.7°N). Growth rate increased significantly with mean rearing temperature between 22 and 30°C. The intercept of the regression of growth rate on temperature increased with elevation, whereas the slope did not change significantly. For any given rearing temperature, growth rate increased with elevation, which suggests that selection to initiate growth at cooler temperatures did not compromise growth rate. Body mass did not differ between the two lower elevations, whereas the highest elevation population had smaller hatchlings and adults. Critical thermal minimum (base temperature) declined with elevation (0.7°C per 1,000 m), and the degree days were 509 across all elevations. For pest management, a base temperature from midelevation of 15.3°C (60°F) and growing degree days of 509 (equivalent to 916 Fahrenheit-based degree days) are reasonable estimates for applications from sea level to 2,700 m.
Early headgear activator treatment of Class II malocclusion with excessive overjet: a randomized controlled trial
Authors: Kallunki Jenny , Bondemark Lars , Paulsson Liselotte
Published: October 2020

Objectives

To compare early headgear activator treatment of Class II malocclusion with excessive overjet with untreated control subjects in terms of the primary outcomes overjet and overbite as well as the effect regarding oral-health-related quality of life (OHRQoL), lip closure, incidence of trauma, and skeletal changes.

Trial design

Two-arm parallel group single-centre randomized controlled trial.

Material and methods

A total of 60 children (mean age 9.5 years) presenting a Class II malocclusion with excessive overjet were recruited. The trial was designed as intention-to-treat and the participants randomized by an independent person not involved in the trial to either early treatment with headgear activator or to an untreated control group (UG). Dental and skeletal variables as well as registrations of OHRQoL, lip closure, and incidence of trauma were recorded. For the treatment group, data were registered at baseline before treatment and when treatment was finished, corresponding to approximately 2 years. For the UG, registrations were made at baseline and at 11 years of age. Observers were blinded to treatment allocation when assessing outcomes.

Results

Early treatment with headgear activator significantly decreased overjet and improved molar relationship when compared with untreated controls. The effects were primarily due to dentoalveolar changes. Early treatment had no evident effect regarding OHRQoL, lip closure, or incidence of trauma. Lack of cooperation resulted in unsuccessful treatments for 27% of the patients.

Limitations

The trial was a single-centre trial and can thus be less generalizable.

Conclusions

The main treatment effect of early headgear activator treatment of Class II malocclusion with excessive overjet is reduction of overjet.

Trial registration

NCT04508322.
Analysis of disulphide bond linkage between CoA and protein cysteine thiols during sporulation and in spores of Bacillus species
Authors: Zhyvoloup Alexander , Yu Bess Yi Kun , Baković Jovana , Davis-Lunn Mathew , Tossounian Maria-Armineh , Thomas Naam , Tsuchiya Yugo , Peak-Chew Sew Yeu , Wigneshweraraj Sivaramesh , Filonenko Valeriy , Skehel Mark , Setlow Peter , Gout Ivan
Published: October 2020

Spores of Bacillus species have novel properties, which allow them to lie dormant for years and then germinate under favourable conditions. In the current work, the role of a key metabolic integrator, coenzyme A (CoA), in redox regulation of growing cells and during spore formation in Bacillus megaterium and Bacillus subtilis is studied. Exposing these growing cells to oxidising agents or carbon deprivation resulted in extensive covalent protein modification by CoA (termed protein CoAlation), through disulphide bond formation between the CoA thiol group and a protein cysteine. Significant protein CoAlation was observed during sporulation of B. megaterium, and increased largely in parallel with loss of metabolism in spores. Mass spectrometric analysis identified four CoAlated proteins in B. subtilis spores as well as one CoAlated protein in growing B. megaterium cells. All five of these proteins have been identified as moderately abundant in spores. Based on these findings and published studies, protein CoAlation might be involved in facilitating establishment of spores’ metabolic dormancy, and/or protecting sensitive sulfhydryl groups of spore enzymes.
Molecular diversity of coronavirus host cell entry receptors
Authors: Millet Jean K , Jaimes Javier A , Whittaker Gary R
Published: October 2020

Coronaviruses are a group of viruses causing disease in a wide range of animals, and humans. Since 2002, the successive emergence of bat-borne severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), swine acute diarrhea syndrome coronavirus (SADS-CoV) and SARS-CoV-2 has reinforced efforts in uncovering the molecular and evolutionary mechanisms governing coronavirus cell tropism and interspecies transmission. Decades of studies have led to the discovery of a broad set of carbohydrate and protein receptors for many animal and human coronaviruses. As the main determinant of coronavirus entry, the spike protein binds to these receptors and mediates membrane fusion. Prone to mutations and recombination, spike evolution has been studied extensively. The interactions between spike proteins and their receptors are often complex and despite many advances in the field, there remains many unresolved questions concerning coronavirus tropism modification and cross-species transmission, potentially leading to delays in outbreak responses. The emergence of SARS-CoV-2 underscores the need to address these outstanding issues in order to better anticipate new outbreaks. In this review, we discuss the latest advances in the field of coronavirus receptors emphasizing on the molecular and evolutionary processes that underlie coronavirus receptor usage and host range expansion.
CRISPR/Cas9-mediated gene-editing technology in fruit quality improvement
Authors: Xu Xin , Yuan Yujin , Feng Bihong , Deng Wei
Published: October 2020

Fruits are an essential part of a healthy, balanced diet and it is particularly important for fibre, essential vitamins, and trace elements. Improvement in the quality of fruit and elongation of shelf life are crucial goals for researchers. However, traditional techniques have some drawbacks, such as long period, low efficiency, and difficulty in the modification of target genes, which limit the progress of the study. Recently, the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 technique was developed and has become the most popular gene-editing technology with high efficiency, simplicity, and low cost. CRISPR/Cas9 technique is widely accepted to analyse gene function and complete genetic modification. This review introduces the latest progress of CRISPR/Cas9 technology in fruit quality improvement. For example, CRISPR/Cas9-mediated targeted mutagenesis of RIPENING INHIBITOR gene (RIN), Lycopene desaturase (PDS), Pectate lyases (PL), SlMYB12, and CLAVATA3 (CLV3) can affect fruit ripening, fruit bioactive compounds, fruit texture, fruit colouration, and fruit size. CRISPR/Cas9-mediated mutagenesis has become an efficient method to modify target genes and improve fruit quality.
The Influence of Chromosomal Environment on X-Linked Gene Expression inDrosophila melanogaster
Authors: Belyi Aleksei , Argyridou Eliza , Parsch John
Published: October 2020

Sex chromosomes often differ from autosomes with respect to their gene expression and regulation. In Drosophila melanogaster, X-linked genes are dosage compensated by having their expression upregulated in the male soma, a process mediated by the X-chromosome-specific binding of the dosage compensation complex (DCC). Previous studies of X-linked gene expression found a negative correlation between a gene’s male-to-female expression ratio and its distance to the nearest DCC binding site in somatic tissues, including head and brain, which suggests that dosage compensation influences sex-biased gene expression. A limitation of the previous studies, however, was that they focused on endogenous X-linked genes and, thus, could not disentangle the effects of chromosomal position from those of gene-specific regulation. To overcome this limitation, we examined the expression of an exogenous reporter gene inserted at many locations spanning the X chromosome. We observed a negative correlation between the male-to-female expression ratio of the reporter gene and its distance to the nearest DCC binding site in somatic tissues, but not in gonads. A reporter gene’s location relative to a DCC binding site had greater influence on its expression than the local regulatory elements of neighboring endogenous genes, suggesting that intra-chromosomal variation in the strength of dosage compensation is a major determinant of sex-biased gene expression. Average levels of sex-biased expression did not differ between head and brain, but there was greater positional effect variation in the brain, which may explain the observed excess of endogenous sex-biased genes located on the X chromosome in this tissue.
Gendering Value Change: Domestic Violence and Feminism in 1970s West Berlin*
Authors: Freeland Jane
Published: October 2020

Feminist domestic violence activists in 1970s West Berlin sought to create a community of women helping women. This was key to feminist work in challenging patriarchal citizenship norms and male violence against women. Tracing the evolution of feminist domestic violence activism in West Berlin, this article argues that feminist ideals and critiques were deradicalized as they were taken up in political and public discourse. Rather than being a political project of creating feminist community or challenging gendered concepts of citizenship, domestic violence activism was entrenched as a women’s issue that women were responsible for addressing. Indeed, examining official public and media support for domestic violence projects exposes how the state leant on women as the drivers of gender equality, in ways that were often unpaid and unacknowledged. Far from contesting patriarchy, popular support for domestic violence initiatives went hand-in-hand with a reinscription of a deeply rooted sexual-moral order that entwined liberal development in Germany with paternal and patriarchal authority since the nineteenth century. In making this argument, this article demonstrates that value change was both limited and functioned within normative boundaries. What change did occur was contingent on the labour of women and feminists, whose activism challenged the power structures and norms that left women vulnerable to abuse. Moreover, in the context of the global economic downturn of the 1970s, grassroots feminist activism held even more importance as it offered West Germany a cheap solution to a systemic issue that could no longer be ignored.
Is type of practice setting associated with physician’s cultural competency training? Analysis from the National Ambulatory Medical Care Survey
Authors: Adigun Ayoola C , Qu Haiyan , Austin Shamly
Published: October 2020

This study examined whether type of physician practice settings was associated with cultural competency training for newly hired physicians. We used data from the 2016 National Ambulatory Medical Care Survey Supplement on Culturally and Linguistically Appropriate Services for Office-based Physician Survey. The survey contains a sample of 397 office-based physician responses completed during the period from August to December 2016 (weighted n = 293306). The outcome variable was whether cultural competency training was required for newly hired physicians. The primary predictor variable was type of physician practice settings. We used logistic regression to analyze the association between physician practice settings and cultural competency training for newly hired physicians adjusting for covariates. About 71% physicians belonged to solo or group practice settings. Among these, only 10.4% required cultural competency training for newly hired physicians. Among other practice settings, 34.8% required the training. Results from logistic regression showed that newly hired physicians in solo or group practices (adjusted odds ratio: 0.22; 95% confidence interval: 0.11–0.44) were less likely to have cultural competency training compared to those in other settings. Practice settings are associated with cultural competency training. Cultural competency training across all practice settings may contribute toward improving patient–physician communication, reducing health disparities, and increasing patient satisfaction.
Vanewrightia gen. nov.—A Highly Variable Taxon of Neotropical Ctenuchina (Lepidoptera: Erebidae: Arctiinae: Arctiini) Revealed by Behavioral Traits
Authors: Boppré Michael , Grados Juan , Laguerre Michel , Monzón Julio
Published: October 2020

A series of different-looking tiger moths was collected at pyrrolizidine alkaloid baits in the daytime in Peru. They proved to be variants of a new genus, Vanewrightia  gen. nov., and a new species, Vanewrightia kiesela  sp. nov., both described here. This species presents a striking example of extensive intraspecific variation within a population. Its discovery demonstrates the importance of sampling moths by means other than collecting with light, of studying patterns of wing undersides, and of the value of barcoding. Specimens found in collections considered here potentially to represent further species of the new genus are documented and discussed; Vanewrightia subflavescens (Kaye, 1911) comb. nov., and Vanewrightia patawaensis (Cerda, 2017) comb. nov. are established; we propose Epidesma parva (Rothschild, 1912) as a junior synonym of E. aurimacula (Schaus, 1905). The newly recognized intraspecific variation greatly challenges delimitation of morphospecies and uncovers uncertainties in the taxonomy of Epidesma Hübner, [1819]. The occurrence of an oblique forewing band in many Lepidoptera and the stunning similarity in overall appearance of variants of Vanewrightia with unrelated taxa, in particular notodontid moths (Josiini) and Chamaelimnas C. & R. Felder, [1885] butterflies (Riodinidae), are discussed in the context of mimicry and crypsis, and some perspectives for further research are suggested.
Susceptibility of global HIV-1 clinical isolates to fostemsavir using the PhenoSense® Entry assay
Authors: Gartland Margaret , Zhou Nannan , Stewart Eugene , Pierce Amy , Clark Andrew , Ackerman Peter , Llamoso Cyril , Lataillade Max , Krystal Mark
Published: October 2020

Background

Fostemsavir is a prodrug of a first-in-class HIV-1 attachment inhibitor, temsavir, that binds to gp120 and blocks attachment to the host-cell CD4 receptor, preventing entry and infection of the target cell. Previous studies using a limited number of clinical isolates showed that there was intrinsic variability in their susceptibility to temsavir.

Objectives

Here, an analysis was performed using all clinical isolates analysed in the Monogram Biosciences PhenoSense® Entry assay as part of the development programme.

Methods

In total, 1337 individual envelopes encompassing 20 different HIV-1 subtypes were examined for their susceptibility to temsavir. However, only seven subtypes (B, C, F1, A, [B, F1], BF and A1) were present more than five times, with subtype B (881 isolates) and subtype C (156 isolates) having the largest numbers.

Results

As expected, variability in susceptibility was observed within all subtypes. However, for the great majority of these viruses, temsavir was highly potent, with most viruses exhibiting IC50s <10 nM. One exception was CRF01_AE viruses, where all five isolates exhibited IC50s >100 nM. For the 607 isolates where tropism data were available, geometric mean temsavir IC50 values were remarkably similar for CCR5-, CXCR4- and dual mixed-tropic envelopes from infected individuals.

Conclusions

These data show that HIV-1 viruses from most subtypes are highly susceptible to temsavir and that temsavir susceptibility is independent of tropism.
Development of a “meta-model” to address missing data, predict patient-specific cancer survival and provide a foundation for clinical decision support
Authors: Baron Jason M , Paranjape Ketan , Love Tara , Sharma Vishakha , Heaney Denise , Prime Matthew
Published: October 2020

Objective

Like most real-world data, electronic health record (EHR)–derived data from oncology patients typically exhibits wide interpatient variability in terms of available data elements. This interpatient variability leads to missing data and can present critical challenges in developing and implementing predictive models to underlie clinical decision support for patient-specific oncology care. Here, we sought to develop a novel ensemble approach to addressing missing data that we term the “meta-model” and apply the meta-model to patient-specific cancer prognosis.

Materials and Methods

Using real-world data, we developed a suite of individual random survival forest models to predict survival in patients with advanced lung cancer, colorectal cancer, and breast cancer. Individual models varied by the predictor data used. We combined models for each cancer type into a meta-model that predicted survival for each patient using a weighted mean of the individual models for which the patient had all requisite predictors.

Results

The meta-model significantly outperformed many of the individual models and performed similarly to the best performing individual models. Comparisons of the meta-model to a more traditional imputation-based method of addressing missing data supported the meta-model’s utility.

Conclusions

We developed a novel machine learning–based strategy to underlie clinical decision support and predict survival in cancer patients, despite missing data. The meta-model may more generally provide a tool for addressing missing data across a variety of clinical prediction problems. Moreover, the meta-model may address other challenges in clinical predictive modeling including model extensibility and integration of predictive algorithms trained across different institutions and datasets.
Effects of Nosema ceranae (Dissociodihaplophasida: Nosematidae) and Flupyradifurone on Olfactory Learning in Honey Bees, Apis mellifera (Hymenoptera: Apidae)
Authors: Bell Heather Christine , Montgomery Corina N , Benavides Jaime E , Nieh James C
Published: October 2020

The health of insect pollinators, particularly the honey bee, Apis mellifera (Linnaeus, 1758), is a major concern for agriculture and ecosystem health. In response to mounting evidence supporting the detrimental effects of neonicotinoid pesticides on pollinators, a novel ‘bee safe’ butenolide compound, flupyradifurone (FPF) has been registered for use in agricultural use. Although FPF is not a neonicotinoid, like neonicotinoids, it is an excitotoxic nicotinic acetylcholine receptor agonist. In addition, A. mellifera faces threats from pathogens, such as the microsporidian endoparasite, Nosema ceranae (Fries et al. 1996). We therefore sought 1) to increase our understanding of the potential effects of FPF on honey bees by focusing on a crucial behavior, the ability to learn and remember an odor associated with a food reward, and 2) to test for a potential synergistic effect on such learning by exposure to FPF and infection with N. ceranae. We found little evidence that FPF significantly alters learning and memory at short-term field-realistic doses. However, at high doses and at chronic, field-realistic exposure, FPF did reduce learning and memory in an olfactory conditioning task. Infection with N. ceranae also reduced learning, but there was no synergy (no significant interaction) between N. ceranae and exposure to FPF. These results suggest the importance of continued studies on the chronic effects of FPF.
Contributions to the Estimation of the Postmortem Interval Through the Length and Body Weight of Two Indigenous Species of South America: Lucilia ochricornis (Diptera: Calliphoridae) and Lucilia purpurascens
Authors: Acosta Ximena , Centeno Néstor D , González-Reyes Andrea X , Corronca José A
Published: October 2020

The early arrival and colonization of species belonging to the family Calliphoridae (Insecta: Diptera) on a corpse represent one of the most reliable means of estimating minimum postmortem interval (PMImin). However, information on the development and life cycles of some Argentine species in this family is not complete. The objective of this work was to contribute new information regarding the larval body size of neotropical species that allow, through the construction of forensic methods, the estimation of a more precise and specific PMImin. This work was conducted on laboratory cultures of larvae of Lucilia ochricornis (Wiedemann) and Lucilia purpurascens (Walker) using as average temperatures: 13.4, 15.1, 22.6, and 23.3°C, which represent the four seasons of the year for the province of Salta. With this information, we constructed isomegalen diagrams and growth models for the obtained variables of larval length and body weight. The mean values of length and body weight differ between both species, indicating that L. purpurascens exceeded L. ochricornis in both variables. In contrast, within each species the mean length and weight remained unchanged between culture temperatures for the three larval instars. Isomegalen diagrams can be used for the entire range of temperatures worked in the laboratory, but the body size entered is approximate. The growth models allow the use of point data but are specific for each culture temperature used.
Biological effects of low-dose γ-ray irradiation on chromosomes and DNA of Drosophila melanogaster
Authors: Tanaka Yoshiharu , Furuta Masakazu
Published: October 2020

While the damage to chromosomes and genes induced by high-dose radiation (HDR) has been well researched in many organisms, the effects of low-dose radiation (LDR), defined as a radiation dose of ≤100 mSv, are still being debated. Recent research has suggested that the biological effects of LDR differ from those observed in HDR. To detect the effect of LDR on genes, we selected a gene of Drosophila melanogaster, known as the multiple wing hair (mwh) gene. The hatched heterozygous larvae with genotype mwh/+ were irradiated by γ-rays of a 60Co source. After eclosion, the wing hairs of the heterozygous flies were observed. The area of only one or two mwh cells (small spot) and that of more than three mwh cells (large spot) were counted. The ratio of the two kinds of spots were compared between groups irradiated by different doses including a non-irradiated control group. For the small spot in females, the eruption frequency increased in the groups irradiated with 20–75 mGy, indicating hypersensitivity (HRS) to LDR, while in the groups irradiated with 200 and 300 mGy, the frequency decreased, indicating induced radioresistance (IRR), while in males, 50 and 100 mGy conferred HRS and 75 and 200 mGy conferred IRR. For the large spot in females, 75 mGy conferred HRS and 100–800 mGy conferred IRR. In conclusion, HRS and IRR to LDR was found in Drosophila wing cells by delimiting the dose of γ-rays finely, except in the male large spot.
Tuberculosis and Notifiable Skin Diseases Amongst A Representative Cohort of Refugees in Germany (2014–16)
Authors: Dissmann Patrick D , Koehring Felix , Fischer Florian
Published: October 2020

Until now, systematic surveillance for infectious diseases in refugees is still missing. For that reason, this study aims at illustrating the prevalence of tuberculosis (TB) and notifiable skin diseases in a representative cohort of refugees in Lippe, a district of the federal state of North Rhine-Westphalia, Germany. We collected data on notifiable communicable diseases (TB, scabies, and head lice) from refugees (n = 8946) based on a medical screening after their arrival from October 2014 until May 2016. Data were analysed using descriptive and bivariate methods. Overall, we found 63 of 8764 screened refugees to have an abnormal TB screening result (0.72%). Of 8946 screened refugees, only 51 individuals were found to have scabies (0.57%) and a further 49 were tested positive for head lice (0.55%). The absolute number of TB cases indicate only a moderate public health burden. However, communicable skin diseases can become a problem in crowded holding camps, where they can cause local outbreaks.
Displaced Social Suffering: Burmese Christian Refugees in a US Midwestern City
Authors: Gu Chien-Juh
Published: October 2020

Refugees’ vulnerability to mental illness has been well documented, but challenges in research remain. Following Bourdieu’s approach to social suffering, this article uses Burmese Christian refugees’ life stories to illustrate their lived realities of displacement in which their despair is produced. These stories reveal not only refugees’ subjective experiences but also various structural inequalities in the sending, transit, and receiving social contexts that hinder their well-being. Burmese Christian refugees’ social suffering is created by varied manmade social problems and processes, including the dictatorship and religious intolerance in Myanmar; human trafficking and gang rape in Thailand; labour exploitation and police corruption in Malaysia; and racial prejudice and oppression in the US. Regardless of their contributions to the blue-collar economy, Burmese refugees endure mistreatment and a lack of benefits and promotions in their labour-intensive factory jobs. Their feelings of displacement continue even after finding religious and political freedom in the resettled country.
Social Connections and Displacement from South Sudan to Uganda: Towards a Relational Understanding of Survival during Conflict
Authors: Stites Elizabeth , Humphrey Alex , Krystalli Roxani
Published: October 2020

South Sudanese fled their communities in large numbers following the outbreak of political violence in 2013, with an estimated 4.5 million forcibly displaced by mid-2018. Of neighbouring countries, Uganda hosts the greatest number of South Sudanese refugees. Based on qualitative data collected in 2018 and 2019 in two refugee settlements in the West Nile sub-region of Uganda, this article examines the social connectedness of refugees during their flight and after their arrival in Uganda. How do refugees rely on the new relationships they form during displacement, and in what ways do these relationships enhance our understanding of the role, forms, and importance of social connectedness during displacement? We analyse how social connections provide material and non-material support, how refugees use scarce resources to negotiate and cultivate social connections, and how gender and status influence inclusion and exclusion within social networks. We find that proximity and shared experience are the two most important factors in social connectedness following displacement and that non-material support plays a critical role in facilitating resilience. Collectively, these findings highlight the significance of a relational, rather than individualistic, approach to survival during displacement. In addition to the theoretical significance of these findings, and the contribution to the growing literature on social connectedness during armed conflict, this article is relevant to humanitarian decision-makers and practitioners who aim to craft programmes that support, rather than undermine, the coping strategies of displaced people.
Environmental dependence of X-ray and optical properties of galaxy clusters
Authors: Manolopoulou M , Hoyle B , Mann R G , Sahlén M , Nadathur S
Published: October 2020

Galaxy clusters are widely used to constrain cosmological parameters through their properties, such as masses, luminosity, and temperature distributions. One should take into account all kind of biases that could affect these analyses in order to obtain reliable constraints. In this work, we study the difference in the properties of clusters residing in different large-scale environments, defined by their position within or outside of voids, and the density of their surrounding space. We use both observational and simulation cluster and void catalogues, i.e. XMM Cluster Survey (XCS) and redMaPPer clusters, Baryon Oscillation Spectroscopic Survey (BOSS) voids, and Magneticum simulations. We devise two different environmental proxies for the clusters and study their redshift, richness, mass, X-ray luminosity, and temperature distributions, as well as some properties of their galaxy populations. We use the Kolmogorov–Smirnov two-sample test to discover that richer and more massive clusters are more prevalent in overdense regions and outside of voids. We also find that clusters of matched richness and mass in overdense regions and outside voids tend to have higher X-ray luminosities and temperatures. These differences could have important implications for precision cosmology with clusters of galaxies, since cluster mass calibrations can vary with environment.
Evolution of timing and spectral characteristics of 4U 1901+03 during its 2019 outburst using the Swift and NuSTAR observatories
Authors: Beri Aru , Girdhar Tinku , Iyer Nirmal K , Maitra Chandreyee
Published: October 2020

We report the results from a detailed timing and spectral study of a transient X-ray pulsar, 4U 1901+03 during its 2019 outburst. We performed broadband spectroscopy in the 1–70 $\rm keV$ energy band using four observations made with Swift and NuSTAR at different intensity levels. Our timing results reveal the presence of highly variable pulse profiles dependent on both luminosity and energy. Our spectroscopy results showed the presence of a cyclotron resonance scattering feature (CRSF) at ∼ 30 keV. This feature at 30 keV is highly luminosity and pulse phase dependent. Phase-averaged spectra during the last two observations, made close to the declining phase of the outburst, showed the presence of this feature at around $30~\rm {keV}$. The existence of CRSF at 30 keV during these observations is well supported by an abrupt change in the shape of pulse profiles found close to this energy. We also found that 30 keV feature was significantly detected in the pulse phase-resolved spectra of observations made at relatively high luminosities. Moreover, all spectral fit parameters showed a strong pulse phase dependence. In line with the previous findings, an absorption feature at around $10~\rm {keV}$ is significantly observed in the phase-averaged X-ray spectra of all observations and also showed a strong pulse phase dependence.
A targeted search for repeating fast radio bursts associated with gamma-ray bursts
Authors: Palliyaguru Nipuni T , Agarwal Devansh , Golpayegani Golnoosh , Lynch Ryan , Lorimer Duncan R , Nguyen Benjamin , Corsi Alessandra , Burke-Spolaor Sarah
Published: October 2020

The origin of fast radio bursts (FRBs) still remains a mystery, even with the increased number of discoveries in the last 3 yr. Growing evidence suggests that some FRBs may originate from magnetars. Large, single-dish telescopes such as Arecibo Observatory (AO) and Green Bank Telescope (GBT) have the sensitivity to detect FRB 121102-like bursts at gigaparsec distances. Here, we present searches using AO and GBT that aimed to find potential radio bursts at 11 sites of past gamma-ray bursts that show evidence for the birth of a magnetar. We also performed a search towards GW170817, which has a merger remnant whose nature remains uncertain. We place $10\sigma$ fluence upper limits of ≈0.036 Jy ms at 1.4 GHz and ≈0.063 Jy ms at 4.5 GHz for the AO data and fluence upper limits of ≈0.085 Jy ms at 1.4 GHz and ≈0.098 Jy ms at 1.9 GHz for the GBT data, for a maximum pulse width of ≈42 ms. The AO observations had sufficient sensitivity to detect any FRB of similar luminosity to the one recently detected from the Galactic magnetar SGR 1935+2154. Assuming a Schechter function for the luminosity function of FRBs, we find that our non-detections favour a steep power-law index (α ≲ −1.1) and a large cut-off luminosity (L0 ≳ 1041 erg s−1).
The mass assembly of high-redshift black holes
Authors: Piana Olmo , Dayal Pratika , Volonteri Marta , Choudhury Tirthankar Roy
Published: October 2020

We use the Delphi semi-analytic model to study the mass assembly and properties of high-redshift (z > 4) black holes over a wide mass range, $10^3 \lt M_{\rm bh}/{\rm \rm M_\odot }\lt 10^{10}$. Our black hole growth implementation includes a critical halo mass ($M_{\mathrm{ h}}^{\mathrm{ crit}}$) below which the black hole is starved and above which it is allowed to grow either at the Eddington limit or proportionally to the gas content of the galaxy. As a consequence, after an initial growth phase dominated by black hole mergers down to z ∼ 7 (9), supermassive black holes in z = 4 halo masses of $M_\mathrm{ h}|_{z=4} \sim 10^{11.75} \, (10^{13.4}) \, {\rm \rm M_\odot }$ mainly grow by gas accretion from the interstellar medium. In particular, we find that (i) while most of the accretion occurs in the major branch for $M_\mathrm{ h}|_{z=4} \sim 10^{11\!-\!12} \, {\rm \rm M_\odot }$ haloes, accretion in secondary branches plays a significant role in assembling the black hole mass in higher mass haloes ($M_\mathrm{ h}|_{z=4} \gtrsim 10^{12} \, {\rm \rm M_\odot }$); (ii) while the Eddington ratio increases with decreasing redshift for low-mass ($M_{\mathrm{ bh}} \lt 10^5 \, {\rm \rm M_\odot }$) black holes, it shows the opposite trend for larger masses. In addition, since the accretion rate depends on the gas mass present in the host halo, the duty cycle of the Eddington-limited accretion phase – which can last up to ≈650 Myr – is crucially linked to the joint assembly history of the black hole and its host halo.
X-ray evolution of the nova V959 Mon suggests a delayed ejection and a non-radiative shock
Authors: Nelson Thomas , Mukai Koji , Chomiuk Laura , Sokoloski Jennifer L , Linford Justin D , Finzell Thomas , Mioduszewski Amy J , Rupen Michael P , Weston Jennifer , Lopes de Oliveira Raimundo
Published: October 2020

X-ray observations of shocked gas in novae can provide a useful probe of the dynamics of the ejecta. Here we report on X-ray observations of the nova V959 Mon, which was also detected in GeV gamma-rays with the Fermi satellite. We find that the X-ray spectra are consistent with a two-temperature plasma model with non-solar abundances. We interpret the X-rays as due to shock interaction between the slow equatorial torus and the fast polar outflow that were inferred from radio observations of V959 Mon. We further propose that the hotter component, responsible for most of the flux, is from the reverse shock driven into the fast outflow. We find a systematic drop in the column density of the absorber between days 60 and 140, consistent with the expectations for such a picture. We present intriguing evidence for a delay of around 40 d in the expulsion of the ejecta from the central binary. Moreover, we infer a relatively small (a few times 10−6 M⊙) ejecta mass ahead of the shock, considerably lower than the mass of 104 K gas inferred from radio observations. Finally, we infer that the dominant X-ray shock was likely not radiative at the time of our observations, and that the shock power was considerably higher than the observed X-ray luminosity. It is unclear why high X-ray luminosity, closer to the inferred shock power, is never seen in novae at early times, when the shock is expected to have high enough density to be radiative.
Translation elongation rate varies among organs and decreases with age
Authors: Gerashchenko Maxim V , Peterfi Zalan , Yim Sun Hee , Gladyshev Vadim N
Published: October 2020

There has been a surge of interest towards targeting protein synthesis to treat diseases and extend lifespan. Despite the progress, few options are available to assess translation in live animals, as their complexity limits the repertoire of experimental tools to monitor and manipulate processes within organs and individual cells. It this study, we developed a labeling-free method for measuring organ- and cell-type-specific translation elongation rates in vivo. It is based on time-resolved delivery of translation initiation and elongation inhibitors in live animals followed by ribosome profiling. It also reports translation initiation sites in an organ-specific manner. Using this method, we found that the elongation rates differ more than 50% among mouse organs and determined them to be 6.8, 5.0 and 4.3 amino acids per second for liver, kidney, and skeletal muscle, respectively. We further found that the elongation rate is reduced by 20% between young adulthood and mid-life. Thus, translation, a major metabolic process in cells, is tightly regulated at the level of elongation of nascent polypeptide chains.
Paris
Authors: Newman Andrew
Published: October 2020

Paris is the capital city of France and center of the Île-de-France region, Europe’s second-largest urban agglomeration. Paris is a globally important hub for finance, education, culture, and the arts, and by some measures it is the world’s most visited international tourist destination. The city’s importance for the field of urban studies is due primarily to (a) its present significance as a global city, and, to a greater extent, (b) its historical importance as a place where a particular version of modernity emerged that, in the late 19th and early 20th centuries, would heavily influence the design and cultural landscapes of cities around the world. For this reason, the urban history of Paris exerts a broad influence in the fields of planning, geography, and architectural history, as well as in public health, the history of science and technology, art history, and literature. Indeed, research on Paris stands out among other cities for the degree to which scholars in the humanities have sought to engage with urban issues. This is due to the fact that a large proportion of the artistic and cultural output associated with Paris ruminates about the nature of urban life itself. This bibliography has been written for a broad Anglophone readership; it therefore privileges scholarship in English. English translations of important French works have been supplied wherever possible. However, in an effort to balance accessibility with rigor, some French-language scholarship is included as well. In several cases, English-language publications by prominent French scholars have been supplied that may not be the best representation of these scholars’ work, but such citations will nevertheless serve to introduce these important figures to an Anglophone audience. Readers should be warned that the small number of French-language citations included here are far from comprehensive, and are primarily intended to round out the bibliography for those Anglophone scholars who read French. The bibliography is organized under the three broad headings: Historicizing Modernity, Linking Past and Present, and Contemporary Paris. The logic for this structure is based on that notion that distinguishing between urban history and contemporary urban studies will be convenient for many readers. However, some of the best work on Paris combines past and present, and a great deal of contemporary work is most engaging when placed in dialogue with the city’s history, and vice versa.