bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: 1,2‐Benzisothiazol‐3‐one 1,1‐Dioxide Inhibitors of Human Mast Cell Tryptase.
Authors: Combrink Keith D. , Guelgeze H. Belgin , Meanwell Nicholas A. , Pearce Bradley C. , Zulan Pi , Bisacchi Gregory S. , Roberts Daniel G. M. , Stanley Paul , Seiler Steven M.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Antitumor Activity of New Derivatives of Flavone‐8‐acetic Acid (FAA). Part 3. 2‐Heteroaryl Derivatives.
Authors: Aitken R. Alan , Bibby Michael C. , Bielefeldt Florian , Double John A. , Laws Andrea L. , Mathieu Anne‐Laure , Ritchie Robert B. , Wilson David W. J.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Nonpeptide Somatostatin Agonists with sst4 Selectivity: Synthesis and Structure—Activity Relationships of Thioureas.
Authors: Liu Shenquan , Tang Cheng , Ho Bin , Ankersen Michael , Stidsen Carsten E. , Crider A. Michael
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Biological Activity of Some 4‐Amino‐3‐cinnolinecarboxylic Acid Derivatives. Part 5. Pyrimido[5,4‐c]cinnolines and Triazepino[7,6‐c]cinnoline.
Authors: Stanczak A. , Ochocki Zb. , Pakulska W.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reactivity of Dimethylphenylsilyllithium Toward 5‐ and 6‐Substituted 1,3‐Dimethyluracil Derivatives.
Authors: Saladino Raffaele , Stasi Luigi , Volpe Gabriele , Nicoletti Rosario , Botta Maurizio
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: De Novo Design, Synthesis, and Biological Activities of High‐Affinity and Selective Non‐Peptide Agonists of the δ‐Opioid Receptor.
Authors: Hruby Victor J. , ET AL. ET AL.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Novel, One‐Pot Synthesis of 2H‐Benz[e]‐1,3‐oxazine‐2‐thiones.
Authors: Vadav Lal Dhar S. , Saigal Sandhya , Pal Daya R.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Novel Synthesis of 5‐Hydrazono‐4a,7‐dihydrodipyrazolo[3,4‐b;4,3‐e]pyridin‐3(2H)‐ones and Their Cyclization to Fused Triazines.
Authors: Attaby Fawzy A. , Eldin Sanaa M. , El‐Neairy Mohamed A. A.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Characterization of Novel Bis‐triazenes: 3,8‐Di[2‐aryl‐1‐azenyl]‐1,3,6,8‐tetraazabicyclo[4.4.1]undecanes and 1,3‐Di‐2‐[(4‐methoxyphenyl)‐1‐diazenyl]imidazolidine. The Reaction of Diazonium Ions with Ethylenediamine/Formaldehyde Mixtures.
Authors: Peori M. Brad , Vaughan Keith , Hooper Donald L.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Autoxidation of 2‐Isobutyl‐5,6‐benzo‐1,3,2‐dioxaborepane (III).
Authors: Kuznetsov V. V. , Mazepa A. V. , Spirikhin L. V.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reductive Intramolecular Cyclization of α‐Bromo Silyl Ethers Mediated by Samarium Diiodide.
Authors: Park H. S. , Lee I. S. , Kwon D. W. , Kim Y. H.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of a New Chiral Nitrogen‐Containing Diselenide as a Precursor for Selenium Electrophiles.
Authors: Santi Claudio , Fragale Gianfranco , Wirth Thomas
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of a Ferrocene Bridged Cyclam: A New Redox‐Active Macrocycle and the Structure of a Nickel(II) Complex with Strongly Coupled Metal Centers.
Authors: Plenio Herbert , Aberle Clemens
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Cyclizing Agents in the Synthesis of β‐Ionone from Pseudoionone.
Authors: Markovich Yu. D. , Panfilov A. V. , Platunov Yu. N. , Zhirov A. A. , Kosenko S. I. , Kirsanov A. T.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of (.+‐.)‐Isoitalicene by Electrolysis under Irradiation as a Key Step.
Authors: Harada Yasuhiro , Maki Shojiro , Niwa Haruki , Hirano Takashi , Yamamura Shosuke
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Olefination Entry for the Synthesis of Enantiopure α,ω‐Diaminodicarboxylates and Azabicyclo[X.Y.0]alkane Amino Acids.
Authors: Gosselin Francis , Lubell William D.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Tin‐ or Magnesium‐Mediated Diastereoselective Aldol‐Type Reactions for the Asymmetric Synthesis of α‐Substituted Serines.
Authors: Sano Shigeki , Miwa Toshio , Liu Xiao‐Kai , Ishii Takahiro , Takehisa Tomoka , Shiro Motoo , Nagao Yoshimitsu
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Peptides Employing Fmoc‐Amino Acid Chlorides and Commercial Zinc Dust.
Authors: Gopi Hosahudya N. , Suresh Babu Vommina V.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Dehydrative Glycosylation by Diethylaminosulfur Trifluoride (DAST)—Tin(II) Trifluoromethanesulfonate—Tetrabutylammonium Perchlorate—Triethylamine System.
Authors: Hirooka Motoko , Koto Shinkiti
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient Syntheses of Penta‐Hydroxylated Cyclohexanones via PdCl2‐Mediated Ferrier‐II Reaction of 6‐O‐Acetyl‐5‐enopyranosides.
Authors: Takahashi Hideyo , Kittaka Hisae , Ikegami Shiro
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Carbon‐Bridged Trehalose. Synthesis of Bis[C‐(β‐D‐galactopyranosyl)]methanol.
Authors: Patro Balaram , Schmidt Richard R.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 6‐Deoxyheptose Derivatives via Cyclic Sulfates and Oxetanes.
Authors: Vargas‐Berenguel Antonio , Santoyo‐Gonzalez Francisco , Calvo‐Asin Jose A. , Calvo‐Flores Francisco G. , Exposito‐Lopez Juan M. , Hernandez‐Mateo Fernando , Isac‐Garcia Joaquin , Gimenez Martinez Juan J.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Use of N‐Pivaloyl Imidazole as Protective Reagent for Sugars.
Authors: Santoyo‐Gonzalez Franciso , Uriel Clara , Calvo‐Asin Jose A.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Be Careful When You Want to Use Buffers in Aqueous Solution of Cyclodextrins. Effect of Buffers on the Formation Constants of 3‐Hydroxy‐2‐naphthoic Acid with β‐Cyclodextrin.
Authors: Yi Zhengping , Huang Zhengzi , Yu Junsheng , Chen Huilan
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Structural Class of Bisindole Alkaloids from the Seeds of Catharanthus roseus: Vingramine and Methylvingramine.
Authors: Jossang Akino , Fodor Pierre , Bodo Bernard
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Studies Toward the Synthesis of (+)‐Palustrine: The First Asymmetric Synthesis of (‐)‐Methyl Palustramate.
Authors: Angle Steven R. , Henry Robert M.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Catalytic Asymmetric Synthesis of Tubifolidine.
Authors: Shimizu Satoshi , Ohori Ken , Arai Takayoshi , Sasai Hiroaki , Shibasaki Masakatsu
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Nitration of Camptothecin with Various Inorganic Nitrate Salts in Concentrated Sulfuric Acid: A New Preparation of Anticancer Drug 9‐Nitrocamptothecin.
Authors: Cao Zhisong , Armstrong Kim , Shaw Marcus , Petry Eddie , Harris Nick
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Total Synthesis of Maesanin and Analogues.
Authors: Poigny Stephane , Guyot Michele , Samadi Mohammad
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Factumycin and Its New Derivative RK‐1009 Enhance Threonine‐phosphorylation of a 60‐kDa Protein in Streptomyces griseus.
Authors: Kakeya Hideaki , Morishita Masayuki , Ikeno Ayumi , Kobinata Kimie , Yano Tatsuya , Osada Hiroyuki
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Studies Relevant to Ellagitannin Chemistry: Highly Diastereoselective Intramolecular Biaryl Coupling in Bis(iodotrimethoxybenzoyl) Hexopyranose Derivatives.
Authors: Dai Dongcheng , Martin Olivier R.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: GTRI‐02, a New Lipid Peroxidation Inhibitor from Micromonospora sp. SA246.
Authors: Yeo Woon‐Hyung , Yun Bong‐Sik , Kim Sang‐Seock , Park Eun‐Kyung , Kim Young‐Ho , Yoo Ick‐Dong , Yu Seung‐Hun
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel Spray‐Pyrolysis Deposition of Cuprous Oxide Thin Films.
Authors: Kosugi Tsuyoshi , Kaneko Shoji
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Role of Catalysis in Solid Oxide Fuel Cell Research
Authors: Thampi K. Ravindranathan
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Nanotechnology of Nanotubes and Nanowires: From Aligned Carbon Nanotubes to Silicon Oxide Nanowires
Authors: Grobert N. , Hare J. P. , Hsu W. K. , Kroto H. W. , Pidduck A. J. , Reeves C. L. , Terrones H. , Terrones M. , Trasobares S. , Vizard C. , et al. et al.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Organometallic Molecular Wires and Other Nanoscale‐Sized Devices. An Approach Using the Organoiron (dppe)Cp*Fe Building Block
Authors: Paul Frederic , Lapinte Claude
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stable Germanium Analogues of Carbenes, Imines, Ketones, Thiones, Selones, and Tellones
Authors: Barrau Jacques , Rima Ghassoub
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Crystal and Molecular Structures of Transition Metal Complexes with N‐ and C‐Bonded Diazoalkane Ligands
Authors: Dartiguenave Michele , Menu Marie Joelle , Deydier Eric , Dartiguenave Yves , Siebald Helmuth
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ring Opening Reactions of Succinimides
Authors: Katritzky Alan R. , Yao Jiangchao , Qi Ming , Chou Yueting , Sikora David J. , Davis Shannon
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthetic Approaches to Chiral Phosphetanes
Authors: Marinetti Angela , Kruger Virginie , Buzin Francois‐Xavier
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Selective Catalysts for the Production of Nitrogen‐Containing Compounds
Authors: Sasaki Yutaka , Fukatsu Michio
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Dimethyldioxirane Oxidations of Some Heterocycles Containing Oxygen or Sulfur: Chemo‐ and Stereoselectivity
Authors: Patonay Tamas , Adam Waldemar , Levai Albert
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Amino Acid Derivatives as Building Blocks and Reagents in Heterocyclic Synthesis
Authors: KoLevar Marijan
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Reactivity of 1H‐Indol‐3(2H)‐one and Related Compounds
Authors: Merour J.‐Y. , Piroelle S. , Joseph B.
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Sonochemistry: Quo Vadis?
Authors: Chanon Michel , Luche Jean‐Louis
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Selected Sonochemical Experiments
Authors: Luche Jean‐Louis
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electron Transfer in Transition‐Metal—Pteridine Systems
Authors: Burgmayer Sharon J. Nieter
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Theoretical Aspects and Quantum Mechanical Calculations of Silaaromatic Compounds
Authors: Apeloig Yitzhak , Karni Miriam
Published: June 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Testicular microlithiasis predicts concurrent testicular germ cell tumors and intratubular germ cell neoplasia of unclassified type in adults
Authors: Tan Iain B. , Ang Kai K. , Ching Boon C. , Mohan Chandra , Toh Chee K. , Tan Min H.
Published: June 2010

BACKGROUND:

There is an increasing body of literature associating testicular microlithiasis (TM), a common finding on testicular ultrasound, with testicular germ cell tumor (TGCT) and intratubular germ cell neoplasia of unclassified type (ITGCNU). Determining these associations is pertinent both clinically and biologically. To the authors' knowledge, no previous systematic review or meta‐analysis has been performed.

METHODS:

A comprehensive systematic literature review was performed without language restrictions through July 2009 and included an exhaustive search of electronic databases and article references. Two reviewers extracted data independently. Studies were categorized according to the clinical context in which sonography was performed. The primary study outcomes were concurrent diagnoses of TGCT or ITGCNU, with TM. In addition, studies with prospective follow‐up of patients with TM were reviewed.

RESULTS:

Thirty‐three studies met inclusion criteria. TM was not associated with an increased risk of TGCT in asymptomatic men. However, in referral populations, TM was associated overall with a risk ratio of 8.5 (95% confidence interval [CI], 4.5‐16.1; P < .001) for a concurrent diagnosis of TGCT and 10.5 (95% CI, 5.3‐20.8; P < .0001) for ITGCNU. Seventeen observational studies were identified in which the interval development of TGCT in patients with TM was reported; however, the majority of those studies did not report the follow‐up of a control arm and could not be summarized.

CONCLUSIONS:

In the presence of risk factors, TM was associated with a substantially elevated risk of a concurrent diagnosis of TGCT and ITGCNU. The authors suggest modifications to recently proposed guidelines for the management of TM. Cancer 2010. © 2010 American Cancer Society.
Regional variation in cancer‐directed surgery and mortality among women with epithelial ovarian cancer in the medicare population
Authors: Fairfield Kathleen M. , Lucas F. Lee , Earle Craig C. , Small Laurie , Trimble Edward L. , Warren Joan L.
Published: June 2010

BACKGROUND:

Regional differences in health services can point to disparities in access to healthcare. The authors performed a population‐based cohort study to examine differences in ovarian cancer treatment and mortality according to geographic region.

METHODS:

The Surveillance, Epidemiology, and End Results (SEER)‐Medicare database was used to identify 4589 women aged ≥65 years with ovarian cancer diagnosed between 1998 and 2002 who had Medicare claims filed from 1998 to 2005. Hospital Referral Region (HRR) was assigned according to patient zip code. The authors calculated the proportion of women in each HRR who underwent cancer‐directed surgery. With HRR as the predictor of interest, mortality and the receipt of cancer‐directed surgery were described in multivariate analyses.

RESULTS:

Among 4589 women with ovarian cancer, 3286 underwent cancer‐directed surgery. The receipt of cancer‐directed surgery varied by HRR (range, 53%‐88%). Women were less likely to undergo cancer‐directed surgery if they were older, nonwhite, had higher stage disease, or had more comorbidities. For example, white women were more likely to undergo such surgery (odds ratio, 1.41; 95% confidence interval, 1.10‐1.82) compared with all nonwhite women. HRR was a significant predictor of cancer‐directed surgery (P = .01). A significant correlation was observed between HRR and all‐cause mortality (P = .02); however, after adjusting for cancer‐directed surgery, that correlation was no longer significant (P = .10).

CONCLUSIONS:

There was regional variation in mortality among Medicare recipients with ovarian cancer, and access to cancer‐directed surgery explained some of that variation. Improving access to high‐quality cancer surgery for ovarian cancer may improve outcomes, particularly for minorities and for older women. Cancer 2010. © 2010 American Cancer Society.
Characteristics of patients with stage III colon adenocarcinoma who fail to receive guideline‐recommended treatment
Authors: Winget Marcy , Hossain Shakhawat , Yasui Yutaka , Scarfe Andrew
Published: June 2010

BACKGROUND:

Many patients with stage III colon adenocarcinoma do not receive adjuvant chemotherapy despite the proven survival advantage it offers. To enhance the provision of optimal cancer care, patient characteristics associated with not receiving guideline‐adherent treatment must be identified among patients with operable, stage III colon adenocarcinoma.

METHODS:

This was a population‐based, retrospective study of all patients who underwent surgery for stage III colon adenocarcinoma diagnosed from 2002 through 2005 in Alberta, Canada. Demographic and treatment information captured in the Alberta Cancer Registry were linked to: 1) hospital discharge data to determine comorbidities, 2) electronic medical records to identify consults with oncologists, and 3) the 2001 Canadian census for neighborhood‐level socioeconomic data. Multivariate log‐binomial regression models were used to identify patient characteristics that were associated with not having a consultation with a medical oncologist and not receiving adjuvant chemotherapy.

RESULTS:

Of the 772 patients who underwent surgery for stage III colon adenocarcinoma and met the eligibility criteria, 618 patients (80%) had a consultation with an oncologist. Of those, 388 patients (63%) initiated adjuvant chemotherapy within 84 days of their surgery. Patient characteristics that were associated with not having a consultation with an oncologist were neighborhood income, geography, age, and comorbidities. Of those patients who had a consultation, after adjusting for comorbidities, only older age was related to not receiving adjuvant chemotherapy.

CONCLUSIONS:

The current results indicated that the proportion of patients with stage III colon adenocarcinoma who did not receive treatment according to evidence‐based guidelines was appreciable. The authors concluded that the association of this failure with patient age, geography, and income is concerning and that evaluation of referral patterns and interventions are needed. Cancer 2010. © 2010 American Cancer Society.
Epithelial membrane protein‐2 expression is an early predictor of endometrial cancer development
Authors: Habeeb Omar , Goodglick Lee , Soslow Robert A. , Rao Rajiv G. , Gordon Lynn K. , Schirripa Osvaldo , Horvath Steve , Braun Jonathan , Seligson David B. , Wadehra Madhuri
Published: June 2010

BACKGROUND:

Endometrial cancer (EC) is a common malignancy worldwide. It is often preceded by endometrial hyperplasia, whose management and risk of neoplastic progression vary. Previously, the authors have shown that the tetraspan protein epithelial membrane protein‐2 (EMP2) is a prognostic indicator for EC aggressiveness and survival. Here the authors validate the expression of EMP2 in EC, and further examine whether EMP2 expression within preneoplastic lesions is an early prognostic biomarker for EC development.

METHODS:

A tissue microarray (TMA) was constructed with a wide representation of benign and malignant endometrial samples. The TMA contains a metachronous cohort of cases from individuals who either developed or did not develop EC. Intensity and frequency of EMP2 expression were assessed using immunohistochemistry.

RESULTS:

There was a stepwise, statistically significant increase in the average EMP2 expression from benign to hyperplasia to atypia to EC. Furthermore, detailed analysis of EMP2 expression in potentially premalignant cases demonstrated that EMP2 positivity was a strong predictor for EC development.

CONCLUSIONS:

EMP2 is an early predictor of EC development in preneoplastic lesions. In addition, combined with our previous findings, these results validate EMP2 as a novel biomarker for EC development. Cancer 2010. © 2010 American Cancer Society.
Age at diagnosis and the utility of prognostic testing in patients with chronic lymphocytic leukemia
Authors: Shanafelt Tait D. , Rabe Kari G. , Kay Neil E. , Zent Clive S. , Jelinek Diane F. , Reinalda Megan S. , Schwager Susan M. , Bowen Debbie A. , Slager Susan L. , Hanson Curtis A. , Call Timothy G.
Published: June 2010

BACKGROUND:

A study was undertaken to analyze the survival of chronic lymphocytic leukemia (CLL) patients relative to age‐matched individuals in the general population and determine the age‐stratified utility of prognostic testing.

METHODS:

All 2487 patients diagnosed with CLL between January 1995 and June 2008 and cared for in the Mayo Clinic Division of Hematology were categorized by age at diagnosis and evaluated for differences in clinical characteristics, time to first treatment, and overall survival (OS).

RESULTS:

Among Rai stage 0 patients, survival was shorter than the age‐matched general population for patients aged <55 years (P < .001), 55 to 64 years (P < .001), and 65 to 74 years (P < .001), but not those aged ≥75 years at diagnosis (P = not significant). CD38, IGHV mutation, and ZAP‐70 each predicted time to first treatment independent of stage for all age groups (all P < .04), but had less value for predicting OS, particularly as age increased. IGHV and fluorescent in situ hybridization (FISH) predicted OS independent of stage for patients aged <55 years (P ≤ .001), 55 to 64 years (P ≤ .004), and 65 to 74 years (P ≤ .001), but not those aged ≥75 years. CD38 and ZAP‐70 each predicted OS independent of stage for only 2 of 4 age categories. Among Rai 0 patients aged <75 years, survival was shorter than the age‐matched population only for IGHV unmutated (P < .001) patients or those with unfavorable FISH (P < .001).

CONCLUSIONS:

Survival of CLL patients aged <75 years is shorter than the age‐matched general population regardless of disease stage. Among patients aged <75 years, the simple combinations of stage and IGHV or stage and FISH identifies those with excess risk of death relative to the age‐matched population. Although useful for predicting time to first treatment independent of stage for patients of all ages, prognostic testing had little utility for predicting OS independent of stage among patients aged ≥75 years. Cancer 2010. © 2010 American Cancer Society.
Building dynamic and transparent integrity measurement and protection for virtualized platform in cloud computing
Authors: Cheng Ge , Jin Hai , Zou Deqing , Zhang Xinwen
Published: June 2010

In the cloud computing infrastructure, there is an increasing demand to maintain and verify the integrity of software stacks running on remote systems and protect users' sensitive data. However, due to the fact that software stacks running on cloud platforms are usually provided and maintained by different authorities (or providers) who are potentially untrusting to each other, the problem of measuring and protecting runtime system integrity becomes very challenging and has not been well addressed yet. In this paper, we present an integrity measurement and protection architecture for software stacks running on a guest operating system (OS) of a virtualized platform in cloud environment. Our solution does not change the guest OS, and thus is transparent to the OS authority. Furthermore, our architecture ensures that sensitive information of users is protected once the integrity of software stacks is broken during runtime. We implement our solution on Xen, and present a simple prototype‐based Nimbus. We demonstrate the capability of dynamically detecting the integrity change of programs in cloud computing, and our evaluation results show that the solution is effective for integrity protection with acceptable performance overhead. Copyright © 2010 John Wiley & Sons, Ltd.
Expression of Gpr177, a Wnt trafficking regulator, in mouse embryogenesis
Authors: Yu Hsiao‐Man Ivy , Jin Ying , Fu Jiang , Hsu Wei
Published: June 2010

Wls/Evi/Srt encoding a multipass transmembrane protein has been identified as a regulator for proper sorting and secretion of Wnt in flies. We have previously demonstrated that Gpr177 is the mouse ortholog required for axis determination. Gpr177 is a transcriptional target of Wnt that is activated to assist its subcellular distribution in a feedback regulatory loop. We, therefore, proposed that reciprocal regulation of Wnt and Gpr177 is essential for the Wnt‐dependent developmental and pathogenic processes. Here, we examine the expression pattern of Gpr177 in mouse development. Gpr177 is expressed in a variety of tissues and cell types during organogenesis. Furthermore, Gpr177 is a glycoprotein primarily accumulating in the Golgi apparatus in signal‐producing cells. The glycosylation of Gpr177 is necessary for proper transportation in the secretory pathway. Our findings suggest that the Gpr177‐mediated regulation of Wnt is crucial for organogenesis in health and disease. Developmental Dynamics 239:2102–2109, 2010. © 2010 Wiley‐Liss, Inc.
Mesenchymal cell remodeling during mouse secondary palate reorientation
Authors: Jin Jiu‐Zhen , Tan Min , Warner Dennis R. , Darling Douglas S. , Higashi Yujiro , Gridley Thomas , Ding Jixiang
Published: June 2010

The formation of mammalian secondary palate requires a series of developmental events such as growth, elevation, and fusion. Despite recent advances in the field of palate development, the process of palate elevation remains poorly understood. The current consensus on palate elevation is that the distal end of the vertical palatal shelf corresponds to the medial edge of the elevated horizontal palatal shelf. We provide evidence suggesting that the prospective medial edge of the vertical palate is located toward the interior side (the side adjacent to the tongue), instead of the distal end, of the vertical palatal shelf and that the horizontal palatal axis is generated through palatal outgrowth from the side of the vertical palatal shelf rather than rotating the pre‐existing vertical axis orthogonally. Because palate elevation represents a classic example of embryonic tissue re‐orientation, our findings here may also shed light on the process of tissue re‐orientation in general. Developmental Dynamics 239:2110–2117, 2010. © 2010 Wiley‐Liss, Inc.
Jarid2 is among a set of genes differentially regulated by Nkx2.5 during outflow tract morphogenesis
Authors: Barth Jeremy L. , Clark Christopher D. , Fresco Victor M. , Knoll Ellen P. , Lee Benjamin , Argraves W. Scott , Lee Kyu‐Ho
Published: June 2010

Nkx2.5, a transcription factor implicated in human congenital heart disease, is required for regulation of second heart field (SHF) progenitors contributing to outflow tract (OFT). Here, we define a set of genes (Lrrn1, Elovl2, Safb, Slc39a6, Khdrbs1, Hoxb4, Fez1, Ccdc117, Jarid2, Nrcam, and Enpp3) expressed in SHF containing pharyngeal arch tissue whose regulation is dependent on Nkx2.5. Further investigation shows that Jarid2, which has been implicated in OFT morphogenesis, is a direct target of Nkx2.5 regulation. Jarid2 expression was up‐regulated in SHF mesoderm of Nkx2.5‐deficient embryos. Chromatin immunoprecipitation analysis showed Nkx2.5 interaction with consensus binding sites in the Jarid2 promoter in pharyngeal arch cells. Finally, Jarid2 promoter activity and mRNA expression levels were down‐regulated by Nkx2.5 overexpression. Given the role of Jarid2 as a regulator of early cardiac proliferation, these findings highlight Jarid2 as one of several potential mediators of the critical role played by Nkx2.5 during OFT morphogenesis. Developmental Dynamics 239:2024–2033, 2010. © 2010 Wiley‐Liss, Inc.
Expression of the familial cardiac valvular dystrophy gene, filamin‐A, during heart morphogenesis
Authors: Norris R.A. , Moreno‐Rodriguez R. , Wessels A. , Merot J. , Bruneval P. , Chester A.H. , Yacoub M.H. , Hagège A. , Slaugenhaupt S.A. , Aikawa E. , Schott J.J. , Lardeux A. , Harris B.S. , Williams L.K. , Richards A. , Levine R.A. , Markwald R.R.
Published: June 2010

Myxoid degeneration of the cardiac valves is a common feature in a heterogeneous group of disorders that includes Marfan syndrome and isolated valvular diseases. Mitral valve prolapse is the most common outcome of these and remains one of the most common indications for valvular surgery. While the etiology of the disease is unknown, recent genetic studies have demonstrated that an X‐linked form of familial cardiac valvular dystrophy can be attributed to mutations in the Filamin‐A gene. Since these inheritable mutations are present from conception, we hypothesize that filamin‐A mutations present at the time of valve morphogenesis lead to dysfunction that progresses postnatally to clinically relevant disease. Therefore, by carefully evaluating genetic factors (such as filamin‐A) that play a substantial role in MVP, we can elucidate relevant developmental pathways that contribute to its pathogenesis. In order to understand how developmental expression of a mutant protein can lead to valve disease, the spatio‐temporal distribution of filamin‐A during cardiac morphogenesis must first be characterized. Although previously thought of as a ubiquitously expressed gene, we demonstrate that filamin‐A is robustly expressed in non‐myocyte cells throughout cardiac morphogenesis including epicardial and endocardial cells, and mesenchymal cells derived by EMT from these two epithelia, as well as mesenchyme of neural crest origin. In postnatal hearts, expression of filamin‐A is significantly decreased in the atrioventricular and outflow tract valve leaflets and their suspensory apparatus. Characterization of the temporal and spatial expression pattern of filamin‐A during cardiac morphogenesis is a crucial first step in our understanding of how mutations in filamin‐A result in clinically relevant valve disease. Developmental Dynamics 239:2118–2127, 2010 © 2010 Wiley‐Liss, Inc.
Temporal and spatial patterning of axial myotome fibers in Xenopus laevis
Authors: Krneta‐Stankic Vanja , Sabillo Armbien , Domingo Carmen R.
Published: June 2010

An image of an X. laevis tadpole showing rhodamine‐labeled transplanted presomitic mesoderm cells (red) in which a subset of cells have differentiated into myotome fibers (shown in orange). The differentiated myotome fibers are stained with the antibody 12/101 (green) and the notochord is stained with Tor 70 (blue). The image was digitally duplicated twice and fused at the anterior end. From Krneta‐Stankic et al., Developmental Dynamics 239:1162–1177, 2010.
Dynamic response of circular bridge decks
Authors: Kunukkasseril V. X. , Ramakrishnan R.
Published: June 2010

A method has been developed for the study of the dynamic response of curved bridge decks on the basis of plate equations in polar co‐ordinates. A general solution for the forced motion of annular sector plates has been obtained by the method of spectral representation. The specific problem of a moving force on the bridge deck is discussed in detail. A method for obtaining the static response from dynamic analysis is suggested. Numerical results are presented to illustrate the influence of the speed of travel of the force and of the physical parameters of the bridge decks on the deformation. A detailed discussion on the numerical results is also included.
Multiple tectonometamorphic imprints in the lower crust: first evidence ofca. 950 Ma (zircon U‐Pb SHRIMP) compressional reworking of UHT aluminous granulites from the Eastern Ghats Belt, India
Authors: Das Kaushik , Bose Sankar , Karmakar Subrata , Dunkley Daniel J. , Dasgupta Somnath
Published: June 2010

Integrated structural, petrological and geochronological study on a suite of granulites from the central part of the Eastern Ghats Belt (EGB), India unveils polyphase tectonothermal evolution. We document (a) M1ultrahigh temperature (UHT) metamorphism (∼1000°C at 6.5–8.5 kbar) on an anticlockwiseP–Ttrajectory simultaneously with early deformations D1–D2involving partial melting, (b) cooling down to ∼ 800°C, 6 kbar that produced a variety of coronae/symplectites (M1R), (c) an unrelated compressional orogeny (D3) that produced deep crustal shears and mylonitic foliation (S3m) at low angles to D1–D2structures and was associated with slight loading, and possible partial melt extraction under granulite facies condition (M2∼7 kbar, 850°C), and (d) localized retrogression (M3) in the presence of melt accompanying D4deformation. This is the first record of the progradeP–Tpath of the superimposed granulite facies metamorphism in the EGB. U‐Pb SHRIMP data of zircon preserves an inherited grain domain ofca. 1700 Ma (207Pb‐206Pb age) that traces back the history of EGB with a lineage of the Mesoproterozoic supercontinent, Columbia. The UHT metamorphosed (peak M1atca. 1000 Ma) and subsequently cooled crustal segment (M1R) was subjected to strong tectonothermal reworking (M2) along a clockwiseP–Tpath at 953 + 6 Ma (concordia age) that partially exhumed the rocks to mid‐crustal levels. A later fluid‐induced retrogressive eventvis‐à‐vismelt crystallization occurred atca. 900 Ma (207Pb‐206Pb age). The post‐peak evolution reveals striking similarities with those recorded in the rocks of the Rayner Complex of east Antarctica, thereby strengthening the notion of Indo‐Antarctic correlation as part of Rodinia. Copyright © 2010 John Wiley & Sons, Ltd.
Correlations of striatal dopamine synthesis with default network deactivations during working memory in younger adults
Authors: Braskie Meredith N. , Landau Susan M. , Wilcox Claire E. , Taylor Stephanie D. , O'Neil James P. , Baker Suzanne L. , Madison Cindee M. , Jagust William J.
Published: June 2010

Age‐related deficits have been demonstrated in working memory performance and in the dopamine system thought to support it. We performed positron emission tomography (PET) scans on 12 younger (mean 22.7 years) and 19 older (mean 65.8 years) adults using the radiotracer 6‐[18F]‐fluoro‐L‐m‐tyrosine (FMT), which measures dopamine synthesis capacity. Subjects also underwent functional magnetic resonance imaging (fMRI) while performing a delayed recognition working memory task. We evaluated age‐related fMRI activity differences and examined how they related to FMT signal variations in dorsal caudate within each age group. In posterior cingulate cortex and precuneus (PCC/Pc), older adults showed diminished fMRI deactivations during memory recognition compared with younger adults. Greater task‐induced deactivation (in younger adults only) was associated both with higher FMT signal and with worse memory performance. Our results suggest that dopamine synthesis helps modulate default network activity in younger adults and that alterations to the dopamine system may contribute to age‐related changes in working memory function. Hum Brain Mapp, 2011. © 2010 Wiley‐Liss, Inc.