bluuebunny/crossref_metadata_2025 huggingface dataset:
Estimation of the level of endothelial factor of vascular growth and monocytic chemoattractant in children cerebral palsy
Authors: Nurzhanova Zulfiya M. , Shilova Anna A. , Bashkina Ol'ga A. , Samotrueva Marina A.
Published: December 2021

Objective. The aim of this article is to assess the role of vascular endothelial growth factor and monocytic chemoattractant in the development of cerebral palsy in children. Materials and methods. Examination of 77 children with different clinical forms of infantile cerebral palsy in the age group from 1 to 16 years was carried out. The content of monocyte chemoattractant (MCP) and vascular growth factor (VEGF) was determined in different forms of cerebral palsy. The obtained data were processed statistically. Results. The analysis of the obtained data revealed a significant increase in the indicators of monocytic chemoattractant and vascular growth factor in children with infantile cerebral palsy compared with healthy children. There were no significant differences between the indicators of MCP and VEGF in children with cerebral palsy and comorbid pathology and children with cerebral palsy without concomitant pathology. Conclusion. The authors of the presented analysis conclude that the determination of monocytic chemoattractant and vascular growth factor has a high diagnostic value for identifying a predisposition to the development of cerebral palsy. Timely detection of an increase in the level of these factors provides a broader prospective for early diagnosis of the disease and for the early implementation of rehabilitation measures accordingly.
O Elogio da Sedentarização na Viagem Contemporânea: Literatura, Pintura e Ecrã
Authors: Castro Maria João
Published: December 2021

Se é verdade que a época em que nos encontramos é “a” época das viagens, não é menos exato que os turistas/viajantes se deslocam cada vez mais fechados frente ao ecrã do lar, viajando através dele. De facto, as novas tecnologias apenas permitem que nos “desloquemos” de outro modo ao interior de nós mesmos, não prejudicando a essência da viagem mas sim possibilitando uma outra forma de experienciar o mundo. Graças ao mundo em rede e à modernidade tecnológica, é hoje possível ver e “estar” em qualquer espaço do globo terrestre, ou seja, tornou-se quase impossível iniciar uma viagem até um ponto desconhecido e não catalogado. Então porque não abdicar da experiência material e, em vez disso, desfrutar da comodidade de viajar no sofá através do relato de outros, sem despender de dinheiro e padecimentos? Porque não tomar de empréstimo a odisseia dos que se deslocam e fazê-la nossa, personalizando-a? Mas ainda assim, alguém poderá dizer que a viagem não acontece? Este artigo pretende mergulhar no outro lado do espelho da viagem, na dinâmica de quem escolhe o elogio da sedentarização para viajar de uma “outra” forma. O viajante de “poltrona” dos tempos de Plínio, o Velho (século I) evoluiu até chegar à época contemporânea numa dinâmica transfronteiriça que se define a partir de um mundo paralelo mas não menos rico.
Propuesta de Modelo de Satisfacción e Intención de Comportamiento en Educación Superior a Distancia
Authors: Bernardo Mercè , Araya-Castillo Luis , Ganga-Contreras Francisco , Sáez Walter
Published: December 2021

Los sectores de la educación superior han alcanzado altos niveles de competencia a nivel global, y Latinoamérica no ha escapado a esta realidad. En este escenario, algunas universidades han respondido a través de la oferta de estudios en modalidad no tradicional (a distancia). Estas instituciones no sólo tienen como desafío que grupos diferentes de estudiantes puedan acceder al sistema de educación superior, sino que también deben enfocar sus esfuerzos en alcanzar adecuados niveles de satisfacción. Dada esta realidad, la presente investigación tiene como objetivo central proponer un modelo de satisfacción e intención de comportamiento en educación superior a distancia (ESaD). Para ello, se realiza en primera instancia un análisis documental, revisando los diversos artículos que se han publicado sobre la materia. Adicionalmente se utiliza como técnica de recolección de datos una encuesta estructurada, la cual se aplica a una muestra de 668 estudiantes de ESaD de Chile. El modelo desarrollado es de tipo reflexivo, de segundo orden y de naturaleza unidimensional, y en el mismo se propone que la satisfacción de los estudiantes influencia en forma positiva sus intenciones de comportamiento. A través de la validación psicométrica se concluye, que en orden de importancia, la satisfacción tiene mayor impacto en la retención, seguida de la lealtad y por último en la disposición a pagar.
Long-term Resilient Labour Strategies to Deal with the Economic Crisis in Europe Using Qualitative Comparative Analysis (QCA)
Authors: Martínez-Molina Sandra , Pavía Paula Sabater , Ferrer Jorge Garcés
Published: December 2021

The crisis has had a negative impact on both European economies and labour markets with different effects among countries, raising the importance of analysing the labour market resilience. This paper seeks to identify which strategies and labour adjustments have led European labour markets to both resilient and non-resilient results by using Qualitative Comparative Analysis (QCA). The findings show two different configurations explaining 57% of the resilient cases and four configurations explaining 74% of the non-resilient cases. The results of this study revealed three important issues. First of all, the same strategy was found to have different results on labour markets. This fact stressed that the context in which different measures are imposed is a decisive factor in their success. Secondly, resilient strategies underlined the importance of “flexibility”, by increasing temporary employment together with other conditions to escape from the crisis. Finally, the non-resilient results stress the importance of the imbalance between the flexicurity dimensions and the effect of the fall in economic activity on not being resilient in the long-term.
Espaços mentais na conceptualização de conversa: dois modelos em análise
Authors: Pereira Bernardo Sandra , De Almeida Velozo Naira , Cosme de Abreu Juan
Published: December 2021

Apresenta-se, neste artigo, análise de excertos de uma conversa à luz da Teoria dos Espaços Mentais (TEM), proposta por Fauconnier (1997), e da Rede de Espaços Comunicativos Básicos (RECB) de Ferrari e Sweetser (2012), com objetivo de evidenciar a adequação da RECB para descrição da organização conceptual de conversa. Os trechos analisados foram extraídos da amostra de XXXX (2002), que consiste na transcrição de uma conversa, com cerca de 30 minutos, gravada durante um jantar, em 1988, com a participação de cinco pessoas. Por meio do confronto entre os modelos da TEM e da RECB para análise da interação verbal, foi possível alcançar mais refinamento teórico e metodológico, já que a postulação de uma base (ground) composta de outros espaços ativados ao longo da construção de sentido da interação em andamento permitiu abarcar conceitos que foram aliados à análise com base na TEM. A retomada da análise de XXXX (2002) com base na RECB revelou, portanto, um aprimoramento na descrição da organização conceptual de conversa em termos de seus aspectos linguísticos, contextuais e interacionais.
Sentidos do agronegócio brasileiro
Authors: Alves Filho Manoel Sebastião , Piovezani Carlos
Published: December 2021

O artigo pretende analisar discursos publicitários do agronegócio nacional, com o intuito de melhor compreender um paradoxo de nossa sociedade: o grande consumo de carne, a matança sistemática de milhões de animais simultâneos a um recrudescimento da sensibilidade humana à causa animal. Com base na Análise do discurso derivada de Michel Pêcheux e seu grupo, e em contribuições de Michel Foucault, procuramos identificar o que é dito nos slogans de empresas alimentícias e o modo como esses enunciados são formulados. Mais precisamente, o nosso intuito é o de analisar a produção de sentidos relacionados ao comércio de produtos alimentícios das indústrias, assim como o apagamento de outros considerados disfóricos pelo setor e silenciados do seu discurso. O material de análise compreende slogans das companhias agropecuárias Friboi e Sadia. Analisaremos o material mediante um método muito conhecido na AD: a formação de relações entre os enunciados dos slogans, entre os slogans do material e entre eles e outros já-ditos do interdiscurso. Essas relações são feitas mediante a identificação e montagem de cadeias parafrásticas: a polissemia constitutiva da linguagem é passível de ser interpretada a partir da produção das paráfrases construídas pelo discurso em suas diferentes condições de produção. Além disso, analisaremos os recursos linguísticos utilizados na constituição dos slogans, como as escolhas lexicais, os encadeamentos sintáticos, as modalidades enunciativas etc. As análises nos permitem inferir a existência de sentidos gastronômicos e econômicos que apagam outros relacionados com o caráter animal, outrora vivo das mercadorias comercializadas pelo agronegócio.
O processo de leitura em língua espanhola: uma proposta didática
Authors: Da Silva Mendonça Felipe
Published: December 2021

Este artigo tem como objetivo apresentar uma proposta didática para a leitura e interpretação de texto em língua espanhola. Para tanto, elegemos o conto El almohadón de plumas, de Horario Quiroga, uma das narrativas curtas mais importantes da América Latina. Nossa proposta é orientada pela visão humanizadora que Candido (2002, 2004) possui da literatura, bem como da noção de Soares (2011) de que a escolarização da referida arte deve ser feita de forma adequada. Além disso, nossa metodologia é baseada nas etapas do processo de leitura apresentadas por Menegassi (2010), a saber: decodificação, compreensão, interpretação e retenção. Com isso, esperamos que os estudantes de língua espanhola se tornem leitores mais críticos e saibam como interpretar e se apropriar do conteúdo temático do texto.
Linguagem, gênero e sexualidade na educação de jovens e adultos: uma proposta de multiletramentos críticos
Authors: Souza da Silva André Luiz , Silva da Rocha Dias Thayse , Bezerra Fábio Alexandre Silva
Published: December 2021

Gênero e sexualidade na escola são temas conflituosos e permeados de percalços na prática pedagógica (MOITA LOPES, 2013). Contrário à crença popular, tratar desses assuntos não se resume a falar abertamente sobre práticas sexuais seguras ou sobre gravidez na adolescência, tampouco se trata de expor os estudantes a objetos ou aparatos que incitem à prática sexual. Com uma compreensão mais ampla sobre como questões de gênero e experiências sobre sexualidades diversas podem impactar no desenvolvimento saudável de alunos/as e de sua relação com a aprendizagem no espaço escolar, esta pesquisa, de natureza qualitativa e de caráter interpretativista, situada no âmbito da linguística aplicada indisciplinar (KLEIMAN, 2013; MOITA LOPES, 2006), analisa a recorrência da temática de gêneros e sexualidades nesse contexto e propõe possibilidades de como abordá-la em sala de aula, a partir de práticas de multiletramentos (COPE; KALANTZIS, 2015; ROJO, 2012), nas aulas de língua portuguesa da Educação de Jovens e Adultos (EJA) mediante práticas de leitura, análise linguística e escrita guiadas pela Proposta Curricular para a Educação de Jovens e Adultos (BRASIL, 2002). Para tanto, objetiva-se: 1) identificar e discutir quais itens linguísticos têm sido utilizados no contexto escolar para se referir às identidades de gênero e sexualidades, e 2) apresentar uma proposta de ensino que contemple a temática proposta com base nas funcionalidades da linguagem (ANTUNES, 2009; BAGNO, 2009). Resultados gerais indicam a necessidade de uma abordagem de identidades de gênero e de sexualidades no contexto escolar que desafie visões essencialistas dos indivíduos e promova uma atitude de respeito à diversidade frente aos desafios que a sociedade contemporânea nos apresenta para além dos muros da escola.
O interacionismo em aquisição de linguagem como um novo lugar teórico para a escrita infantil
Authors: Pereira Lima Carvalho Magda Wacemberg
Published: December 2021

Este trabalho consiste em apresentar o interacionismo em aquisição de linguagem como alternativa à investigação da aquisição da linguagem escrita, uma vez que essa proposição articula um referencial teórico que possibilita a abertura de uma nova perspectiva de análise fundamentada na relação sujeito/língua. Partimos, então, do movimento feito pela pesquisadora brasileira Cláudia de Lemos, em busca de uma teoria de linguagem que analisasse o percurso linguístico da criança e, também, de sua articulação entre a linguística estruturalista de base europeia e a psicanálise lacaniana, proposta que influenciou os trabalhos de Sônia Borges e Zelma Bosco. Para essas autoras, os escritos do outro funcionam como um espelho para a criança no início do percurso de aquisição da linguagem escrita, em razão de que a materialidade dos diversos textos e a interação da criança com essa materialidade é o que vai facilitar o aparecimento de aspectos gráficos e textuais na escrita inicial da criança.
Aquisição segmental e prosódica nas produções verbais de crianças prematuras
Authors: Tenório da Silva Kyvia Fernanda , Payão Luzia Miscow da Cruz , Júnior Miguel José Alves de Oliveira
Published: December 2021

Na aquisição de uma língua, a criança começa a realizar ajustes para produzir a língua-alvo (MATZENAUER; MIRANDA, 2010; MATZENAUER, 2015 PAYÃO; COSTA, 2016). Essa aquisição pode ser afetada pela idade gestacional e pelo peso. Este trabalho partiu da hipótese de que há entre os prematuros defasagens quanto à aquisição segmental consonantal, vocálica e prosódica, correlacionando a idade gestacional e o peso ao nascer. O objetivo da presente pesquisa foi analisar a aquisição segmental consonantal, vocálica e prosódica nas produções verbais de prematuros, considerando a idade gestacional e o peso ao nascer. Este estudo comparou a quantidade de segmentos consonantais e vocálicos e a quantidade de processos fonológicos entre os prematuros ao longo das seis coletas, tendo como referência a aquisição segmental e prosódica apontada pela literatura sobre desenvolvimento linguístico típico do PB. Os dados de fala espontânea de onze crianças, avaliadas entre 12 a 25 meses, provêm de um banco de dados longitudinal coletados entre 2014 e 2018. Os achados evidenciam que os prematuros não produziram todos os segmentos da língua portuguesa até os 20 meses de idade corrigida. A correção da idade não compensou a existência do atraso presente nos prematuros. A aquisição prosódica revelou-se defasada quanto ao preenchimento segmental das sílabas átonas e tônica, uma vez que a sílaba tônica se destacou em relação às átonas e os processos fonológicos de maior relevância foram a não realização de uma sílaba ou mais e não realização de segmento no onset simples. Os prematuros estão em atraso por não preenchem os segmentos em todas as posições silábicas, podendo afetar o desempenho linguístico em idades posteriores.
Reflexões metaortográficas às margens do romance “A mais encantadora mulher” (1903), de Gonzaga Filho
Authors: Alves deLima Maria Hozanete , Morais de Melo Felipe
Published: December 2021

No ano de 1903, José Basileu Neves Gonzaga Filho (02/12/1849 – 09/09/1931) publica o romance A mais encantadora mulher – um romance para senhoras. À época, a escrita das palavras era marcada por variações gráficas, de modo que poderíamos encontrar, por exemplo, no mesmo texto, os pares “charta/carta”, “mez/mes” e “asa/aza”. Ressentia-se o romancista de não haver um discurso comum para a grafia dos termos da língua. Assim, ao escrever seu romance, Gonzaga Filho elabora um pequeno léxicon para justificar a escrita de um conjunto de vocábulos. Este trabalho segue um percurso metodológico de natureza bibliográfica e documental, está orientado pelos pressupostos teóricos de estudos grafemáticos desenvolvidos por alguns historiadores da língua do mundo hispânico (SÁNCHEZ-PRIETO BORJA, 1998; PENSADO, 1998; FRAGO GRACIA, 2002; RAMÍREZ LUENGO, 2012) e objetiva refletir sobre algumas motivações elencadas por Gonzaga Filho (1903) para justificar suas soluções gráficas, sejam elas fonéticas, etimológicas, prosódicas ou de harmonia (neolatina). Encontramos em Gonzaga Filho uma postura metaortográfica que se insere no seio da história da ortografia da língua portuguesa e que revela o percurso que a escrita da língua portuguesa foi tomando, em sincronias passadas, rumo à sua estandardização
O processo de reescrituração da palavra “muro” em textos jornalístico de revista “Veja”
Authors: Carneiro Lemes Renata , Mahmudo Karim Taisir
Published: December 2021

O presente artigo tem como objetivo, sob a ótica da semântica do acontecimento, analisar o processo de reescrituração da palavra muro , em outras palavras,  o modo como a referida palavra ao se repetir produz um novo significado. Para isso, a analise constituirá de quatro textos jornalísticos da revista Veja publicados nos anos 2014, 2015 e 2017, que tematizam sobre a palavra muro na relação com outros sentidos que rememoram um passado enunciativo, no presente do acontecimento. A base teórica e metodológica está fundamentada em conceitos da teoria da semântica do acontecimento, conforme proposta por Guimarães (2002, 2004 e 2005). Assim, analisaremos o modo como o processo de reescrituração se constitui em textos jornalísticos que tematizam o “muro” enquanto acontecimento enunciativo, de modo que o locutor-jornalista, ao enunciar, é afetado por seu lugar social no acontecimento enunciativo. Tudo  isso  nos  fez  observar o processo de significação de outro(s) sentido(s) da palavra muro pelo efeito da repetição nos textos jornalísticos.
TAXONOMIC CONTRIBUTION TO THE KNOWLEDGE OF THE ORIBATID MITE GENUS PROTORIBATES (ACARI, ORIBATIDA, HAPLOZETIDAE)
Authors: Subías Luis S. , Ermilov Sergey G. , Shtanchaeva Umukusum Ya. , Friedrich Stefan
Published: December 2021

A new oribatid mite subgenus, Protoribates (Perubates) subgen. n. (Oribatida, Haplozetidae), with type species Protoribates (Perubates) davidi sp. n., is proposed from the primary evergreen lowland rainforest of Amazonian Peru. It differs from the nominate genus in the presence of lamellar cusps and extra porose areas on the notogaster. A new generic diagnosis of Protoribates is provided.
A NEW SPECIES AND NEW RECORDS OF STIGMAEIDAE (ACARI: PROSTIGMATA) FROM WESTERN SIBERIA
Authors: Khaustov Alexander A.
Published: December 2021

During a study of predatory mites in Western Siberia, a new species, Stigmaeus amphibius sp. n. (Acari: Stigmaeidae), was collected from wet soil near a lake. Eryngiopus hamedanicus Khanjani, Mohammadi and Nazari, 2014, Eustigmaeus bisetalis (Doğan, 2004) comb. n. (from Ledermuelleriopsis), E. vacuus Doğan, 2005, Ledermuelleriopsis rizeiensis Doğan, 2004 and L. plumosa Willmann, 1951 are recorded from Russia for the first time. Females of Eustigmaeus bisetalis and Ledermuelleriopsis rizeiensis are redescribed based on materials from Western Siberia.
Problem płynnej odpowiedzialności w perspektywie badań nad rozwojem zrównoważonym
Authors: Leźnicki Marcin
Published: December 2021

Streszczenie nie jest dostępne.
Wychowanie do zrównoważonego rozwoju w szkole podstawowej
Authors: Mielczarek Artur W.
Published: December 2021

Streszczenie nie jest dostępne
Poczucie tożsamości młodzieży dorastającej. Badania jakościowe
Authors: Kłosowski Marcin
Published: December 2021

Dorastanie to czas przejścia z okresu dzieciństwa do dorosłości. Jednym z najistotniejszych zadań tego okresu jest ukształtowanie poczucia tożsamości. Zgodnie z teorią stadiów rozwoju psychospołecznego Erika Eriksona (1968), na okres adolescencji przypada kryzys tożsamościowy, a najważniejszym pytaniem staje się: kim jestem? W prezentowanym artykule szczegółowiej podjęto problem treści poczucia tożsamości oraz formy jego prezentacji u nastolatków w wieku 13–19 lat. Za pomocą autorskiego narzędzia przeprowadzono badania jakościowe wśród uczniów szkół gimnazjalnej oraz licealnej (badania zakończyły się jeszcze przed całkowitą likwidacją tego podziału szkół). W badaniu wzięło udział 188 uczniów (N = 188, uczniowie szkoły gimnazjalnej n = 96, uczniowie szkoły licealnej n = 92, średnia wieku = 16,20). W wyniku przeprowadzonych analiz okazało się, iż istnieją pewne różnice w zakresie treści i formy wypowiedzi na temat własnej tożsamości między uczniami szkół gimnazjalnej i licealnej. Na ich podstawie można również stwierdzić, że młodzież różnicują nie tylko konkretne treści, ale w ogóle umiejętność bądź nieumiejętność odpowiedzi na pytanie o to, kim się jest. Dorastanie to czas przejścia z okresu dzieciństwa do dorosłości. Jednym z najistotniejszych zadań tego okresu jest ukształtowanie poczucia tożsamości. Zgodnie z teorią stadiów rozwoju psychospołecznego Erika Eriksona (1968), na okres adolescencji przypada kryzys tożsamościowy, a najważniejszym pytaniem staje się: kim jestem? W prezentowanym artykule szczegółowiej podjęto problem treści poczucia tożsamości oraz formy jego prezentacji u nastolatków w wieku 13–19 lat. Za pomocą autorskiego narzędzia przeprowadzono badania jakościowe wśród uczniów szkół gimnazjalnej oraz licealnej (badania zakończyły się jeszcze przed całkowitą likwidacją tego podziału szkół). W badaniu wzięło udział 188 uczniów (N = 188, uczniowie szkoły gimnazjalnej n = 96, uczniowie szkoły licealnej n = 92, średnia wieku = 16,20). W wyniku przeprowadzonych analiz okazało się, iż istnieją pewne różnice w zakresie treści i formy wypowiedzi na temat własnej tożsamości między uczniami szkół gimnazjalnej i licealnej. Na ich podstawie można również stwierdzić, że młodzież różnicują nie tylko konkretne treści, ale w ogóle umiejętność bądź nieumiejętność odpowiedzi na pytanie o to, kim się jest.
Polska adaptacja narzędzia do badania subiektywnej witalności w ujęciu Ryana i Frederick
Authors: Mudło-Głagolska Karolina
Published: December 2021

W ostatnich latach zwraca się uwagę na fenomenologiczną jakość witalności. Konstrukt subiektywnej witalności jako marker dobrostanu psychicznego ma tę nad nim przewagę, że jest bardziej dostępny w doświadczeniu fenomenologicznym, jest niezależny od zewnętrznych kryteriów dobrostanu i różni się od innych konstruktów z tego obszaru (takich jak np. afekt pozytywny, zaangażowanie w pracę, flow czy satysfakcja z życia). Dotąd możliwość oceny subiektywnej witalności była w Polsce ograniczona, zatem przetestowano trafność i rzetelność polskiej wersji Skali subiektywnej witalności. W próbie 709 osób oceniono trafność czynnikową trzech wersji skali w języku polskim. Na podstawie α Cronbacha i mocy dyskryminacyjnej narzędzie można uznać za rzetelne. Przetestowano trafność skali w aspekcie zbieżnym i różnicowym na podstawie zależności subiektywnej witalności od innych konstruktów psychologicznych. Częściowo potwierdzono wartość predykcyjną satysfakcji z zaspokojenia potrzeb psychologicznych w ogóle i w odniesieniu do pracy. Analiza różnic międzygrupowych wykazała, że wynik subiektywnej witalności u osób chorych i zdrowych somatycznie był istotnie różny. Skalę subiektywnej witalności można uznać za narzędzie trafne i rzetelne. Zalecane jest stosowanie jej wersji 5-pozycyjnej.
Cechy proaktywnej osobowości a zachowania autoagresywne skazanych mężczyzn odbywających karę pozbawienia wolności
Authors: Kwiatkowski Bartosz
Published: December 2021

Obowiązek przymusowego przebywania w izolacji penitencjarnej wywołuje szkody osobiste w postaci zaburzeń emocji, motywacji czy zachowania. Negatywnym skutkiem deprywacji potrzeb skazanych jest ich podwyższona skłonność do dokonywania intencjonalnych samouszkodzeń podczas odbywania kary pozbawienia wolności. Oprócz czynników sprzyjających występowaniu zachowań autoagresywnych istnieją także czynniki chroniące, które bezspornie rzadziej są przedmiotem opracowań psychologicznych. W badaniu wzięło udział 50 skazanych mężczyzn, odbywających karę pozbawienia wolności po raz kolejny w życiu. Do ustalenia poziomu ich proaktywności wykorzystano Skalę proaktywności w izolacji więziennej (SPIW15), natomiast ich skłonność do autoagresji ustalono przy użyciu Inwentarza samouszkodzeń (ISAS). W artykule omówiono wyniki badań własnych, które dowiodły, że proaktywność jako cecha osobowości ma negatywny związek z autoagresją recydywistów. W ochronie przed autoagresywnymi zachowaniami skazanych największy udział mają proaktywne działania nastawione na uzyskiwanie poczucia własnej kompetencji i wsparcia rodzinnego. Ponadto w badaniu wykazano, że proaktywni skazani mają istotnie dłuższe przerwy między aktami autoagresji, a także ich proaktywne działania współwystępują z deklaracjami dotyczącymi chęci zaprzestania samouszkodzeń w przyszłości.
EL COMPORTAMIENTO HIGIÉNICO DE Apis mellifera EN RELACIÓN CON EL NIVEL DE INFESTACIÓN DE Varroa destructor
Authors: Paco A. , Martos A. , López Víctor , Chura Julián
Published: December 2021

El comportamiento higiénico y el nivel de infestación de varroa sobre abejas adultas, y la relación entre estas variables, fueron evaluadas sobre colonias de abejas Apis mellifera. El comportamiento higiénico se determinó mediante la técnica del pinchando de pupas con aguja, y la tasa de infestación de varroa en abejas adultas se calculó en muestras de abejas adultas por el método del tamizado. La correlación entre el comportamiento higiénico y la tasa de infestación de varroa en abejas adultas fue determinado usando la prueba de correlación de Spearman y el programa SAS versión 9.4. El valor promedio de comportamiento higiénico fue de 99,8% para el 52% de colonias altamente higiénicas, mientras que la tasa de infestación de varroa en abejas adultas promedio fue de 1,69% para el 92,3% de colonias con baja infestación por el ácaro. Se encontró una correlación negativa (rs=-0,397) altamente significativa (P<0,01). Los resultados encontrados sugieren la existencia de colonias de A. mellifera con> <0,01). Los resultados encontrados sugieren la existencia de colonias de A. mellifera con características de resistencia a Varroa destructor, por los altos valores de comportamiento higiénico y las bajas tasas de infestación de varroa en abejas adultas.
ACTIVIDAD ENZIMÁTICA DE PALTA FUERTE (persea americana) DURANTE EL ALMACENAMIENTO EN REFRIGERACIÓN
Authors: Liñan-Pérez Jhoselyn , Puma-Isuiza Gustavo
Published: December 2021

El objetivo del presente estudio fue evaluar el efecto de tratamientos físicos (tratamiento térmico a 45 °C: TT), químicos (ácido cítrico al 1,0 %: AC 1,0 %; ácido ascórbico al 0,75 %: AA 0,75 % y Tripolifosfato de sodio al 1,0 %: TPS 1,0 %), combinados (ácido cítrico al 0,2 % y 45 °C: AC 0,2 % + TT) y un tratamiento control (C), en la inhibición del pardeamiento enzimático, medido a través de la actividad enzimática (Δabsorbancia/min) de la Polifenol Oxidasa (PPO), en el tejido de palta almacenada a temperatura de refrigeración (4°C). Se evaluaron los parámetros de color CIELAB (L*a*b*), ∆E* , ∆C* y el porcentaje de oscurecimiento. Además, se realizó una prueba sensorial con 50 consumidores quienes evaluaron la preferencia de las muestras de palta tratadas. En general, los tratamientos anti-pardeantes redujeron la actividad enzimática de la PPO donde la muestra sometida con ácido cítrico al 0,2 % y 45 °C obtuvo los mejores resultados en la reducción de la actividad enzimática y los parámetros de color.
Antioxidant, Antimicrobial, and Molecular Docking Studies of Novel
Chalcones and Schiff Bases Bearing 1, 4-naphthoquinone Moiety
Authors: Elkanzi Nadia Ali Ahmed , Hrichi Hajer , Bakr Rania B.
Published: December 2021

Background:

The 1,4-naphthoquinone ring has attracted prominent interest in the field of medicinal
chemistry due to its potent pharmacological activities such as antioxidant, antibacterial, antifungal,
and anticancer.

Objective:

Herein, a series of new Schiff bases (4-6) and chalcones (8a-c & 9a-d) bearing 1,4-
naphthoquinone moiety were synthesized in good yields and were subjected to in-vitro antimicrobial,
antioxidant, and molecular docking testing.

Methods:

A facile protocol has been described in this study for the synthesis of new derivatives (4-7, 8ac,
and 9a-d) bearing 1,4-naphthoquinone moiety. The chemical structures of all the synthesized compounds
were identified by 1H-NMR, 13C-NMR, MS, and elemental analyses. Moreover, these derivatives
were assessed for their in-vitro antimicrobial activity against gram-positive, gram-negative bacteria, and
fungal strains. Further studies were conducted to test their antioxidant activity using DPPH (2,2-diphenyl-
1-picrylhydrazyl) scavenging assay. Molecular docking studies were realized to identify the most likely
interactions of the novel compounds within the protein receptor.

Results:

The antimicrobial results showed that most of the compounds displayed good efficacy against
both bacterial and fungal strains. The antioxidant study revealed that compounds 9d, 9a, 9b, 8c, and 6
exhibited the highest radical scavenging activity. Docking studies of the most active antimicrobial compounds
within GLN- 6-P, recorded good scores with several binding interactions with the active sites.

Conclusion:

Based on the obtained results, it was found that compounds 8b, 9b, and 9c displayed the
highest activity against both bacterial and fungal strains. The obtained findings from the DPPH radical
scavenging method revealed that compounds 9d and 9a exhibited the strongest scavenging potential. The
molecular docking studies proved that the most active antimicrobial compounds 8b, 9b and 9c displayed
the highest energy binding scores within the glucosamine-6-phosphate synthase (GlcN-6-P) active site.
Calcium Modification Therapies in Contemporary Percutaneous Coronary
Intervention
Authors: Zaidan Mohammad , Alkhalil Mohammad , Alaswad Khaldoon
Published: December 2021

Coronary artery calcifications (CAC) has been known to be associated with worse Percutaneous Coronary Intervention (PCI) short- and long-term outcomes. Nowadays with the increased prevalence of the risk factors leading to CAC in the population and also more PCI procedures done in older patients and with the growing number of higher risk cases of chronic total occlusion (CTO) PCI and PCI after coronary artery bypass grafting(CABG), severe cases of CAC are now encountered on a daily basis in the catheterization lab and remain a big challenge to the interventional community, making it crucial to identify cases of severe CAC and plan a CAC PCI modification strategy upfront. Improved CAC detection with intravascular imaging helped identifying more of these severe CAC cases and predicting response to therapy and stent expansion based on CAC distribution in the vessel. Multiple available therapies for CAC modification has evolved over the years, familiarity with the specifics and special considerations and limitations of each of these tools is essential in the choice and application of these therapies when used in severe CAC treatment.
In this review we discuss CAC pathophysiology, modes of detection, and different available therapies for CAC modification.
DILI-Stk: An Ensemble Model for the Prediction of Drug-induced Liver
Injury of Drug Candidates
Authors: Lee Jingyu , Yu Myeong-Sang , Na Dokyun
Published: December 2021

Background:

Drug-induced liver injury (DILI) is a leading cause of drug failure, accounting
for nearly 20% of drug withdrawal. Thus, there has been a great demand for in silico DILI prediction
models for successful drug discovery. To date, various models have been developed for DILI prediction;
however, building an accurate model for practical use in drug discovery remains challenging.

Methods:

We constructed an ensemble model composed of three high-performance DILI prediction
models to utilize the unique advantage of each machine learning algorithm.

Results:

The ensemble model exhibited high predictive performance, with an area under the curve of
0.88, sensitivity of 0.83, specificity of 0.77, F1-score of 0.82, and accuracy of 0.80. When a test dataset
collected from the literature was used to compare the performance of our model with publicly available
DILI prediction models, our model achieved an accuracy of 0.77, sensitivity of 0.82, specificity of 0.72,
and F1-score of 0.79, which were higher than those of the other DILI prediction models. As many published
DILI prediction models are not available for public access, which hinders in silico drug discovery,
we made our DILI prediction model publicly accessible (http://ssbio.cau.ac.kr/software/dili/).

Conclusion:

We expect that our ensemble model may facilitate advancements in drug discovery by
providing a highly predictive model and reducing the drug withdrawal rate.
Cytotoxic Evaluation and Molecular Docking Studies of Aminopyridine Derivatives
as Potential Anticancer Agents
Authors: Ilyas Umair , Alkury Lina Tariq , Naaz Shagufta , Muhammad Syed Aun , Nadeem Humaira , Altaf Reem , Zaman Shahiq uz , Faheem Muhammad , Sajid Imran , Cheema Mohsin Tasawar , Mannan Abdul , Shah Fawad Ali , Li Shupeng
Published: December 2021

Background:

The development of resistance to available anticancer drugs is increasingly becoming a major
challenge and new chemical entities could be unveiled to compensate for this therapeutic failure.

Objectives:

The current study demonstrated whether N-protected and deprotected amino acid derivatives of 2-
aminopyridine could attenuate tumor development using colorectal cancer cell lines.

Methods:

Biological assays were performed to investigate the anticancer potential of synthesized compounds. The in silico ADME profiling and docking studies were also performed by docking the designed compounds against the active binding site of beta-catenin (CTNNB1) to analyze the binding mode of these compounds. Four derivatives 4a, 4b, 4c, and 4d were selected for investigation of in vitro anticancer potential using colorectal cancer cell line HCT 116. The anti-tumor activities of synthesized compounds were further validated by evaluating the inhibitory effects of these compounds on the target protein beta-catenin through in vitro enzyme inhibitory assay.

Results:

Biological assays were performed to investigate the anticancer potential of synthesized compounds. The in
silico ADME profiling and docking studies were also performed by docking the designed compounds against the active
binding site of beta-catenin (CTNNB1) to analyze the binding mode of these compounds. Four derivatives 4a, 4b, 4c,
and 4d were selected for investigation of in vitro anticancer potential using colorectal cancer cell line HCT 116. The
anti-tumor activities of synthesized compounds were further validated by evaluating the inhibitory effects of these
compounds on the target protein beta-catenin through in vitro enzyme inhibitory assay.

Conclusion:

In conclusion, the synthesized compounds showed significant anti-tumor activities both in silico and in
vitro, having potential for further investigating its role in colorectal cancer.
Status of Indonesia's sovereign rights in the north natuna sea conflict area consequences of China's nine-dash line claim
Authors: Fernandes Inggrit , Daulay Zainul , Ferdi Ferdi , Delfiyanti Delfiyanti
Published: December 2021

The existence of sovereign rights in the North Natuna Sea has begun to be disturbed since China's claim of traditional fishing rights was strengthened by the nine-dash line claim. This claim includes the North Natuna Sea area into China's territorial sea, which makes this area a conflict area. The problem in this research is the existence of traditional fishing ground rights in UNCLOS III 1982 and the impact of the nine-dash line claim on Indonesia's sovereign rights in the conflict area of ??the North Natuna Sea. This study uses a normative legal research method with a statutory and conceptual approach. The results of the study explained that the 1982 UNCLOS III did not regulate traditional fishing ground, and the impact of the nine-dash line claim is very significant, as can be seen from the activities of Chinese fishers in the North Natuna Sea, which are supported by Chinese coast guard vessels, which have disrupted Indonesia's enjoyment of its sovereign rights. Thus, it can be concluded that the traditional fishing ground rights with the nine-dash line claim are not based on international law but are only based on China's unilateral claims and create conflicts that impact Indonesia.
POTENSI MINUMAN FUNGSIONAL BERBASIS SUSU DENGAN ISOLAT BIJI ATAU KECAMBAH KORO PEDANG DALAM PENCEGAHAN PENYAKIT KARDIOVASKULAR
Authors: Kanetro Bayu , Slamet Agus , Budiyanto Cahyo
Published: December 2021

Susu sapi diketahui mengandung nutrisi yang tinggi namun demikian adanya kolesterol dan asam lemak jenuh menjadi faktor pemicu penyakit kardiovaskular yang menjadi pembatas bagi konsumen orang dewasa ataupun orang tua. Penambahan isolat protein biji atau kecambah koro pedang 3% pada penelitian sebelumnya memberikan profil asam amino yang lebih baik terutama Glisin, Alanin, Serin, Arginin, dan Lisin yang berperan dalam pencegahan penyakit kardiovaskular. Tujuan penelitian ini adalah untuk mengetahui pengaruh penambahan isolat biji ataupun kecambah koro pedang 3% terhadap kadar kolesterol dan profil asam lemak sebelum dan setelah in vitro dibandingkan dengan susu sapi tanpa penambahan. Adapun rancangan penelitian yang digunakan adalah rancangan acak lengkap yang terdiri dari susu sapi murni tanpa penambahan (K0), susu dengan isolat biji koro pedang 3% (K1) dan susu dengan isolat kecambah koro pedang 3% (K2). Hasil penelitian menunjukkan bahwa penambahan isolat biji atau kecambah koro pedang 3% pada susu sapi menurunkan kadar kolesterol susu sapi dan berbeda signifikan dibandingkan susu tanpa penambahan. Profil asam lemak susu ditambah isolat kecambah ataupun biji koro pedang adalah lebih baik dibandingkan susu sapi tanpa penambahan yaitu kadar asam lemak jenuh lebih rendah namun sebaliknya asam lemak tak jenuh lebih tinggi. Penurunan kadar kolesterol dan profil asam lemak setelah pencernaan in vitro terbaik adalah pada susu isolat kecambah koro pedang 3%. Oleh karenanya, pada penelitian ini dapat disimpulkan penambahan isolat protein biji atau kecambah koro pedang 3% memiliki potensi sebagai minuman fungsional untuk pencegahan penyakit kardiovaskular.
Enhanced Production of Citric Acid by Mutant PN12 of Aspergillus fumigatus Using Statistical Design
Authors: Aghera Payal
Published: December 2021

Distillery spent wash is an unwanted residual liquid waste generated during alcohol production. It is a potential source for production of different industrially important products. Distillery spent wash is dark colored and has many organic compounds as a waste. In this experiment, removal of color and organic compounds was carried out by anaerobic treatment. The treated spent wash was utilized for citric acid production with the help of microorganisms. The current study was performed with the treated spent wash which was applied for high level of citric acid production by a mutant strain of Aspergillus fumigatus PN12. The parent strain Aspergillus fumigatus PN12 was mutagenized by UV exposure to enhance citric acid production. After UV exposure investigation, mutant strain was selected for optimization and statistical method. The best citric acid production obtained was, 26.45 g/L at 30 ℃ with pH 6.0, 0.1 g/L of KH2PO4 and (NH4)2SO4 under OFAT. Under RSM optimization, maximum citric acid production was achieved as 30.89 g/L. Thus, the process optimization through the statistical approach resulted in a 1.16-fold enhancement in citric acid production as compared to that of the OFAT parametric conditions. Citric acid producing enzymes such as aconitase, NAD+-isocitrate dehydrogenase and NADP+ isocitrate dehydrogenase was studied. Maximum activity (U/mg) of aconitase (3.19±0.023), NAD+-isocitrate dehydrogenase (3.0±0.15) and NADP+ isocitrate dehydrogenase (2.91±0.17) was observed at 96 h. The present study can conclude that spent wash is potential source for citric acid production. Utilization of mutant strain of Aspergillus fumigatus PN12 is beneficiary for large scale industrial fermentation and citric acid production.
KINABALU NATIONAL PARK, UNESCO WORLD HERITAGE SITE: ASSESSMENT OF ENVIRONMENTAL ISSUES, TOURIST SATISFACTION AND PARK MANAGEMENT
Authors: Abdul Latip Normah , Karim Rehmat , Jaafar Mastura , Marzuki Azizan , Ahmad Abdul Ghafar , Syed Abdullah Sharifah Zahhura , Omar@Umar Mohd Umzarulazijo
Published: December 2021

National parks serve as rural ecotourism attractions, the management of which must strike a balance between economic productivity and the protection of the park’s natural value. Faced with the increased pressure of rising visitor numbers park management must give greater consideration to the tourist experience and tourist satisfaction. This paper examines the relationship between park management, tourist satisfaction, and environmental issues. Moreover, this paper considers the mediating role of environmental issues on the relationship between park management and tourist satisfaction. A questionnaire survey was administered to visitors of Malaysia’s Kinabalu National Park. In total, 351 completed questionnaires were returned and Partial Least Squares-Structural Equation Modelling (PLS-SEM) was used to analyze the resultant data using SmartPLS 2.0. The results showed that park management has a strong effect on tourist satisfaction and environmental issues. The results also revealed that environmental issues play a mediating role in the relationship between park management and tourist satisfaction.
POST-CONSERVATION EVALUATION (PCE) ON HISTORIC BUILDINGS: AUTHENTICITY OF ADAPTIVE REUSE MUSEUMS IN GEORGE TOWN, UNESCO WORLD HERITAGE SITE
Authors: Abdul Aziz Muhammad Firzan
Published: December 2021

Adaptive reuse has apparently become a favourable means of built heritage conservation in the UNESCO World Heritage Site (WHS) of Melaka and George Town. In most cases, adaptive reuse implementations inflict conflicting demands to historic buildings in terms of meeting new functional needs and retaining physical authenticity. Inappropriate implementation of adaptive reuse for historic buildings within WHS may result in the violation of Outstanding Universal Values (OUVs). The purpose of this study is to determine the authenticity condition of historic buildings on their post-conservation phase, after adaptive reuse implementation. Five historic buildings namely the Penang State Museum (PSM), Made in Penang Interactive Museum (MIPIM), Sun Yat Sen Museum (SYSM), Batik Painting Museum (BPM) and Dark Mansion-3D Glow in the Dark Museum (DM) were evaluated through field observation. In accommodating the museum function, three elements were found to be intervened inappropriately at these buildings namely the internal wall, windows, and building services. The findings of this evaluative study can be useful to technical review panels appointed by heritage authorities, in scrutinising heritage impact assessment (HIA) reports and evaluating future proposals concerning adaptive reuse projects of historic buildings within WHS.
Burnout Syndrome in public school teachers in Sorocaba, São Paulo, Brazil
Authors: Souza Maíra Cazeto Lopes de , Lucca Sérgio Roberto de
Published: December 2021

Objective: To identify the prevalence of Burnout Syndrome (BS) in a sample of 107 elementary school teachers (cycle II and high school) in Sorocaba/SP and analyze possible associations of psychosocial and organizational factors at work with the dimensions of burnout. Methods: Cross-sectional epidemiological study, conducted through a selection of a convenience sample, which included 107 teachers from state schools in Sorocaba using the following criteria: having entered the public teaching career for at least one year and working predominantly as a teacher, that is, not having more hours in administrative positions. Data collection was conducted in eight schools in the city, and two forms were used, the “Maslach Burnout Inventarie-Educators Survey” (MBI-ES) and a biopsychosocial form. Pearson's chi-square test and logistic regression analysis were performed for data analysis, adopting a significance level of 5%. Results: There was a prevalence of BS in 4.7% of teachers, with 29% of teachers showing high Emotional Exhaustion, 33.6% high Depersonalization and 18.7% low Professional Fulfillment. Positive associations were found between factors such as lack of recognition, dissatisfaction with work and situations of harassment with the dimensions of the BS. Conclusion: The results suggest a warning sign for illness characterized by burnout in the sample of teachers studied.
The experience of successful use of melatonin, L‑arginine and L‑carnitine in treatment post-COVID‑19 pain syndromes in persons with cystic transformation of the pineal gland
Authors: Baliazina E. V. , Stepanova A. Y. , Baliazin V. A.
Published: December 2021

As an introduction, the article presents a small review of the literature devoted to the problem of clinical variants of postovoid syndrome and, in particular, headaches and back pain. There are 6 cases with various headaches and 1 case with back pain in patients with cystic transformation of the pineal gland after a verified COVID-19 infection. All patients were diagnosed with melatonin, L‑arginine and L‑carnitine deficiency before treatment. After the replacement therapy, the pain syndrome was stopped in all patients within 10 days, and a month after the start of treatment, the indicators of melatonin, L‑arginine and l‑carnitine returned to the reference values of the norm.
Hepatorenal syndrome: new insights about pathogenesis (part 1))
Authors: Krutikov E. S. , Vostrikova A. N. , Krutikova M. S.
Published: December 2021

An analysis of literature reviews, clinical studies, experimental research, clinical recommendations from pubmed / Medline and ELIBRARY databases on keywords for“liver cirrhosis”and“hepatorenal syndrome”was carried out. In accordance with modern studies, the idea of the pathophysiology of hepatorenal syndrome was revised in recent years, departing from the assumption that the development of this pathology is associated only with renal hypoperphusion due to the development of peripheral systemic arterial vasodilation. Today, the effect of cardiovascular, immune, endocrine systems, coagulation systems, hematological changes, endothelial dysfunction, reception of drugs and other factors for the development of renal dysfunction is studied.
Study of type 1 vascular adhesion molecules in patients with acute myocardial infarction with ST segment elevation at different body weights
Authors: Zakovryashina I. N. , Khaisheva L. A. , Shlyk S. V. , Garina I. A.
Published: December 2021

Objective: to study the level of adhesion molecules in patients with STEMI with different BMI at the hospital stage and 12 months after the index event.

Materials and methods: the study included 126 people with STEMI who had undergone PCI and 27 people in the control group. The analysis of the level of svcam‑1 in peripheral blood at the beginning of the disease and after 12 months was carried out, BMI and waist volume were measured. An assessment of the nature and frequency of complications after STEMI was performed.

Results: the levels of biomarkers of the vascular endothelial adhesion molecule type 1 increase during the acute period of stemi, statistically signifi tly decrease, but remain increased by 3.5 times 12 months after the index event compared with the initial values. There was no association of VCAM‑1 with visceral obesity in the groups of our patients. Vascular endothelial adhesion molecules of type 1 increase in patients with a fatal outcome, as well as with an increase in the severity of OSN and CHF. Thus, VCAM 1 can be a predictor of an unfavorable outcome of AMI.

Conclusions: the article presents the study of a marker of systemic inflammation VCAM‑11 in patients with STEMI with various types of obesity or BMI at the stage of hospitalization and outpatient follow‑up during the year. The determination of the VCAM‑1 level can be used to assess the intensity of the inflammatory process and the risk of adverse outcomes.