bluuebunny/crossref_metadata_2025 huggingface dataset:
Peningkatan Keterampilan Editing Video Sinematik Melalui Pelatihan Aplikasi CapCut pada Siswa SMPN 06 Bengkulu Tengah
Authors: Fajarini Sri Dwi , Mukhlizar  , Turmudi Imam
Published: January 2025

SMPN 06 Bengkulu Tengah adalah sekolah yang terletak di Desa Taba Lagan Kecamatan Semidang Lagan Kabupaten Bengkulu Tengah dimana sekolah ini terletak di lokasi yang strategis, menjadikannya pilihan utama bagi banyak siswa. Selain itu, sekolah ini didukung oleh tenaga pengajar yang berkualitas tinggi, sehingga menarik minat para orang tua untuk menyekolahkan anak-anak mereka di sini. Pendidikan SMP adalah jenjang pendidikan formal yang bertujuan untuk mempersiapkan siswa memasuki Sekolah Menengah Atas. Pada usia ramaja seperti ini siswa harus dikenalkan dengan teknologi yang canggih karena anak milenial atau generasi-Z harus banyak menggunakan sistem teknologi yang terkenal dan lagi marak-maraknya sekarang yakni aplikasi capcut. Tujuan dari kegiatan pengabdian ini adalah untuk mengedukasi siswa bagaimana menggunakan aplikasi Capcut sebagai sarana untuk meningkatkan keterampilan siswa/i SMP 06 Bengkulu Tengah, mengembangkan ide-ide siswa/i SMP 06 Bengkulu Tengah, dan meningkatkan keterampilan siswa/i SMP 06 Bengkulu Tengah. Pelatihan yang dilakukan ini tidaklah mudah, diperlukan banyak strategi untuk membuat aplikasi Capcut mudah diterima dan dipahami siswa. Salah satu metode untuk mencapainya adalah memberikan penjelasan kepada siswa tentang pengertian aplikasi Capcut, kelebihan dan kekurangan, serta fungsi dan fitur-fitur yang ada pada aplikasi capcut serta langsung melakukan pelatihan kepada siswa agar siswa benar-benar memahaminya. Hasil pelatihan menunjukkan bahwa 68% siswa SMPN 06 Bengkulu Tengah memahami materi tentang Cara Menggunakan Aplikasi Capcut.
Pelatihan Ice Breaking dalam Mengoptimalisasi Kegiatan Pembelajaran Bagi Guru SMK PGRI 39 Jakarta
Authors: Pertiwi Indah , Retnawati Saptina , Ulfa Marissa
Published: January 2025

Era modernisasi belajar bukan lagi menjadi kegiatan sehari-hari yang dinikmati oleh para siswa. Siswa malas atau bosan dalam belajar merasa ingin melepaskan kegiatan lain yang menyenangkan dibandingkan dengan kegiatan belajar lainnya, seperti bermain handphone, bermain game online, dan menggangu teman. Kegiatan belajar membutuhkan konsentrasi yang intens. Pembelajaran yang diselingi ice breaking ini memberikan semangat peserta didik untuk mengikuti pembelajaran dan juga melatih konsentrasi peserta didik dalam memahami materi yang diajarkan. Kegiatan ice-breaking dengan variasi dan ekspresi yang sesuai telah terbukti mengembalikan konsentrasi siswa. Hasil survei awal di SMK PGRI 39 Jakarta, guru-guru belum mampu secara optimal mengupayakan kegiatan ice breaking dengan baik, untuk mendukung proses pembelajaran. Oleh karena itu, setelah berdiskusi dengan kepala sekolah dan para guru, maka ditentukan solusi berupa pelatihan penggunaan ice breaking dalam mengoptimalisasi pembelajaran untuk para guru. Pemilihan teknik penyelesaian masalah berbentuk “pelatihan” dikarenakan melalui teknik tersebut, guru dapat belajar sekaligus mempraktikan atau learning by doing. Peningkatan keterampilan dan kemampuan guru-guru dalam menggunakan teknik ice breaking dalam pembelajaran akan dibuktikan dengan praktek ice breaking dalam pembelajaran. Pelatihan ini diberikan kepada 15 orang guru sebagai peserta dengan secara workshop dan dengan menggunakan simulasi. Hasil dari pelatihan ini, guru-guru bisa mengetahui bentuk-bentuk dari ice breaking dan mampu mensimulasikan dalam kelas contoh.
Larvicidal Efficacy of Citrus Sinensis Extracts on Laboratory Strains of Aedes aegypti and Culex quinquefasciatus
Authors: Muthuraman A. , Shajahan A. , Hussain M.I. Zahir , Venkatesh B. Pon
Published: January 2025

Mosquito-borne diseases pose significant global health risks, particularly in tropical regions. Aedes and Culex mosquitoes are key vectors for diseases like dengue, Zika, and West Nile virus. This study explores the larvicidal potential of orange peel (Citrus sinensis) extracts against Ae. aegypti and Cx. quinquefasciatus mosquitoes. Extracts were prepared using acetone, methanol, hexane, and petroleum ether and their respective efficacy was tested on Ae. aegypti and Cx. quinquefasciatus larvae. Larvicidal assays revealed that the hexane extract exhibited the highest efficacy, with LC50 values of 13.24 ppm for Ae. aegypti and 38.82 ppm for Cx. quinquefasciatus, achieving up to 98% and 95% mortality rates at 100 ppm, respectively. The petroleum ether extract was notably effective against Cx. quinquefasciatus, while acetone and methanol extracts showed moderate efficacy. Statistical analysis, including Probit analysis, confirmed the significance of these findings. These findings suggest that orange peel extracts, particularly hexane, could serve as effective, eco-friendly larvicides, offering a sustainable alternative to traditional mosquito control methods.
Abundance and Diversity of Floral Visitors on Jamun (Syzygium cumini L. Skeels)
Authors: G Eswarappa , Somashekar R K , B Gagan
Published: January 2025

The reproductive output in the form of seeds is dependent on pollinating species and the rate of effective pollination. In view of this fact the study on “Abundance and diversity of floral visitors on Jamun (Syzygium cumini L. Skeels) was carried out at Regional Horticultural Research and Extension Centre, College of Horticulture (RHREC); UHS sub campus, GKVK, Bengaluru-560 065. Totally thirty-one species of floral visitors were recorded on the wild and cultivated varieties of S. cumini, among them twelve were Hymenopterans (39%), six were Dipterans (19%), five were Lepidopterans (16%), seven were Coleopterans (23%) and one species belonged to Hemiptera (3%). Among the honey bees that visited the flowers, the per cent abundance of A. dorsata was highest followed by A. florea, A. cerana and T. iridipennis and they constituted 69.00 to 72.39 per cent of floral visitors. The per cent composition of ants that visited the flowers was highest, followed by Dipterans, Lepidopterans and Coleopterans and they together constituted 27.00 to 31.00 per cent. The diversity (H) of floral visitors varied throughout the day during 100 per cent flowering stage on all the wild and cultivated varieties of S. cumini. The peakactivity of honeybees, including other floral visitors was observed during morning hours on all wild and cultivated varieties of S. cumini. Among the floral visitors, the dominance (d) and diversity of honey bees was comparatively highest.
OLHAR O OUTRO E CONSTRUIR A SI VIVÊNCIAS POTENTES: EXTENSÃO E FORMAÇÃO DOCENTE
Authors: Silva Giovanni Codeça da , Bezerra Bruna Cruz Engelhard , Pereira Ana Luisa Bispo , Gouveia Chrystiane Dantas Barrreto , Silva Silvana Batista
Published: January 2025

A curricularização da extensão no ensino superior, previsto na meta 12, estratégia 12.7 do Plano Nacional de Educação (Lei nº 13.005, de 25 de junho de 2014), busca tornar factível a realização da extensão com significação para os educandos. “Olhar o Outro e construir a Si” busca explicitar o percurso de construção da curricularização da extensão na Universidade Veiga de Almeida (UVA), no Rio de Janeiro. Bem como, apresentar o sentido proposto para os projetos de extensão: de caráter formativo (ligados à responsabilidade social e a identidade político-cidadã); de metodologia popular (seguindo a proposta freireana) e críticos (buscando avaliar e autoavaliar seus impactos internos e externos).
PENGARUH PENDIDIKAN KESEHATAN MELALUI MEDIA AUDIO VISUAL TERHADAP PENINGKATAN PENGETAHUAN PADA IBU HAMIL TENTANG ANEMIA
Authors: Frilasari Heni , Triwibowo Heri , Walten Dewi Erma Natalia
Published: January 2025

Salah satu factor dari beberapa faktor yang ikut berperan sebagai factor penyebab anemia adalah pengetahuan ibu hamil. Wanita hamil yang memiliki pengetahuan yang baik tentang anemia dapat membantu memahami dan mengetahui tentang anemia dalam melindungi diri dan bayinya. Tujuan penelitian ini adalah untuk mengetahui pengaruh pendidikan kesehatan melalui media audio visual sebelum dan sesudah terhadap peningkatan pengetahuan pada ibu hamil tentang anemia di wilayah Puskesmas Puri. Desain penelitian yang digunakan adalah quasi eksperimental dengan pendekatan one group pretest-posttest. Populasi dalam penelitian ini adalah sebanyak 36 orang ibu hamil di wilayah Puskesmas Puri dengan teknik purposive sampling diberi kriteria inklusi dan ekslusi, diperoleh sampel sebanyak 30 orang ibu hamil di Desa Banjaragung. Variabel independent dalam penelitian ini pendidikan kesehatan melalui media audio visual dan variabel dependent pengetahuan ibu hamil tentang anemia. Data di ambil menggunakan kuesioner pengetahuan. Pengolahan data dengan editing, coding, scoring, entry data, tabulating, dengan uji statistic normalitas uji Wilcoxon. Hasil penelitian pretest tingkat pengetahuan kurang 16 orang (53,3%) dan posttest tingkat pengetahuan baik18 orang (60%). Terdapat pengaruh pendidikan kesehatan melalui media audio visual terhadap peningkatan pengetahuan pada ibu hamil tentang anemia dengan nilai (p) sebesar 0,000 (p<0,05). Pemberian pendidikan kesehatan melalui media audio visual merupakan suatu upaya preventif dan persuasive dalam mengurangi resiko komplikasi anemia selama kehamilan
Fishing for Ocean Data in the East Australian Current
Authors:   UNSW Sydney, Lago Véronique , Roughan Moninya , Kerry Colette , Knuckey Ian
Published: January 2025

Knowledge of the three-dimensional structure and variability of ocean temperature is critical for understanding ocean circulation, heat uptake, marine extremes, and the abundance and distribution of marine life. While satellite technology offers near-global coverage of surface ocean temperatures, subsurface observations represent a big gap in the coastal ocean record. Here we present the first results from FishSOOP (Fisheries Ships of Opportunity), Australia’s pilot program that uses commercial fishing gear to collect subsurface ocean data. Since early 2023, temperature and pressure data have been collected through the FishSOOP project across the Australian continental shelf and upper-slope waters. These new data provide insights into the development of marine heatwaves throughout the water column and new understanding of how the East Australian Current interacts with shelf water to produce nonuniform temperature changes. Comparison with the South East Australian Coastal Ocean Forecasting System (SEA-COFS) model indicates potential for improving forecasts of upper ocean heat content and subsurface temperatures by filling large gaps in observational data coverage. FishSOOP already provides a step change in the amount of open access temperature data available as well as ocean information critical to marine industries for operational decision-making, showing the value of using fishing vessels to observe challenging western boundary current regions.
Análisis integral de variables estratégicas para la intervención en la cadena de suministro
Authors: Rivas Lozano María Alejandra
Published: January 2025

En el siguiente artículo se presentan los resultados de una intervención aplicada a una pequeña empresa del estado de Colima. Se realizó un análisis detallado de las variables críticas requeridas para la optimización de su cadena de suministro, como compras, inventario, producción y atención y expectativas del consumidor; para ello se investigaron los procesos de preproducción, producción y postproducción. Su finalidad fue determinar si el manejo de estas etapas era adecuado para garantizar la productividad y satisfacción del cliente. Se aplicaron dos metodologías: la exploratoria, para investigar fenómenos poco conocidos, usando entrevistas semiestructuradas y grupos focales, logrando con ello obtener información cualitativa sobre las experiencias y percepciones de los participantes y la descriptiva, donde se empleó una encuesta estructurada compuesta por 92 preguntas organizadas en tres categorías que permitió describir lo que existía en el contexto natural de la organización; otra encuesta para proveedores y una más para los clientes. La intervención identificó áreas de mejora y defectos en los procesos, como la falta de seguimiento en la atención al cliente y una administración inadecuada de proveedores, mismas que afectan adversamente su rendimiento y generan ineficiencia en el negocio. Además, se logra destacar el impacto social de la intervención, al mostrar cómo una cadena de suministro eficiente puede beneficiar tanto a la empresa como a la comunidad. Por último, este artículo proporciona la base para la toma de decisiones informadas y la implementación de mejoras sostenibles a largo plazo en la dirección empresarial.
CONVERGENCE AND STABILITY OF A NEW THREE-STEP ITERATIVE TECHNIQUE IN CONVEX METRIC SPACE
Authors:   Department of Mathematics, Thapar Institute of Engineering and Technology, Patiala - 147004, Punjab, INDIA, Rani Bhumika , Kaur Jatinderdeep ,   Department of Mathematics, Thapar Institute of Engineering and Technology, Patiala - 147004, Punjab, INDIA, Bhatia Satvinder Singh ,   Department of Mathematics, Thapar Institute of Engineering and Technology, Patiala - 147004, Punjab, INDIA
Published: January 2025

In order to approximate the fixed points of a contractive mapping, a new three-step iteration approach is proposed in this study. Additionally, the suggested scheme's stability and convergence are taken into account, and its efficacy for various problems is explored. The novel technique outperforms all the well-known three-step strategies that are currently accessible in the literature, according to several experiments that are described.
NEW TYPE OF DEGENERATE CHANGHEE POLYNOMIALS OF THE SECOND KIND
Authors:   Department of Electrical Engineering, Prince Mohammad Bin Fahd University, P.O. Box: 1664, Al Khobar 31952, SAUDI ARABIA, Khan Waseem Ahmad
Published: January 2025

In this paper, we consider the new type of degenerate Changhee numbers and polynomials of the second kind which are different from the previously introduced degenerate Changhee numbers and polynomials of the second kind by Kim-Kim. We investigate some properties of these numbers and polynomials. In addition, we give some new relations between the new type of degenerate Changhee polynomials of the second kind and the Carlitz's degenerate Euler polynomials.
NEW GENERALIZATION OF CHEBYSHEV-LIKE POLYNOMIALS AND THEIR APPLICATIONS
Authors:   Department of Mathematics, School of Chemical Engineering and Physical Sciences, Lovely Professional University, Punjab - 144411, INDIA, Pandey Pankaj , Verma Anu ,   Department of Mathematics, School of Chemical Engineering and Physical Sciences, Lovely Professional University, Punjab - 144411, INDIA
Published: January 2025

This study is focused on the development of a new generalized version of four known types of Chebyshev polynomials. We come up with four different kind of generalized Chebyshev polynomials using a modified recurrence relationship with different starting points. We also get Binet's formula for generalized Chebyshev’s polynomials. The Binet formula is obtained by mathematical induction. The matrix representation and the characteristic equation are presented using matrix algebra properties for these polynomials. We also explore about the sum, products, and subtraction of the roots of the characteristic equation of the generalized Chebyshev polynomials. Finally, we have shown how Chebyshev-like polynomials can be used in practice with examples.
CRIMINALIZATION OF FRAUD CRIMES IN CAPITAL MARKET TRANSACTIONS
Authors: Ambarwati Mega Dewi
Published: January 2025

As an economic instrument, capital market is not free from certain parties abuse to enrich themselves and it against the law. Crimes in the capital market sector are complex and difficult to prove, let alone being brought before a court, given the nature of the market which is very sensitive to material facts (news related to the course of judicial process) in the form of information related to the capital market. Crimes of capital market sector are complex and difficult to prove, especially being brought before a court, within the characteristic of the market which is very sensitive to material facts (related to the course of judicial process) in form of information related to the capital market. The objective of developing capital market as the basis for sustainable development plan is to increase economic growth and income distribution, to develop an economy that is globally oriented related to the advances in science and technology for the prosperity of the people. The purpose of this study is to find out how government's role as an effort to avoid fraud in the capital market is detrimental to investors. The research method used statutory approach and conceptual approach. Based on the results and discussion in the study, it can be concluded that, the adoption of the division of offenses into two types, namely capital market crime offenses and capital market offenses, shows that the Investment Law follows the provisions contained in the Criminal Code which are laws (general provisions).
PEDUM PAMONG AGAINST TEGAK UMAH TUA IN BALINESE CUSTOMARY LAW
Authors: Sari Kadek Dwinta Pradnya , Resen Dr. Made Gde Subha Karma
Published: January 2025

Umah Tua land is essential for the Balinese community's balance and must be preserved by every generation. Balinese customary law includes the concept of pedum pamong, which involves temporarily distributing inherited property until a final distribution occurs. However, there are no specific regulations in Balinese law addressing pedum pamong and its legal consequences for Umah Tua. This is neccessary as Umah Tua ownership is communal and includes preservation duties, especially for the tegak sanggah within Umah Tua. This article aims to explain the concept of pedum pamong in the context of Balinese customary law and analyze its juridical consequences on the tegak umah tua. This research applies a descriptive normative legal approach, reliant on the analysis of literature related to Balinese customary law. The research findings revealed that no specific regulation on pedum pamong is identified in Balinese customary law. Pedum pamong focuses on the temporary distribution of inheritance until it is distributed in perpetuity. Due to its temporary nature, the ownership of tegak umah objects within the scope of umah tua may change upon the testator's passing or cremation, with the exception of tegak bale dangin and merajan. Therefore, it is necessary to establish a specific and comprehensive guideline regarding pedum pamong in Balinese customary law.
ANALYSIS OF THE SOCIAL FUNCTION OF LAND RIGHTS FOR PUBLIC INTEREST
Authors: Safitri Adelia , Sugiharto Dr.
Published: January 2025

This research examines the evolution of land rights in Indonesia, focusing on their social function. Drawing on von Savigny's perspective, which emphasizes the influence of family, nation, and state on law and culture, this research  explores how these factors have shaped Indonesian land rights, blending customary and European legal traditions. This research aims to analyze the shift in land rights following the enactment of the Basic Agrarian Law (UUPA) in 1960, which transformed land control from communal and religious systems to state regulation for the benefit of the people. The UUPA establishes that all land rights carry a social function, requiring their use to align with public interest and community welfare. Using a normative juridical approach, this research reviews key legal frameworks, including Law No. 5 of 1960 and Law No. 2 of 2012. The research findings reveal that the state plays a central role in ensuring the social function of land, particularly through policies that balance individual rights with public benefit, aligning with utilitarian ideals. This research concludes that while land rights are guaranteed under Indonesian agrarian law, their social function is prioritized, ensuring land use serves public interest and promotes equitable development.
THE COMPLAIN MANAGEMENT STRATEGY IN DEALING WITH ALLEGED MALPRACTICE IN DIGITAL ERA
Authors: Mahardhika Rosliana
Published: January 2025

According to the data from Central Indonesian Doctors Association (IDI) Legal Aid Institute, in Indonesia there are approximately 210 cases of suspected malpractice. Medical accidents have caused real injury to the patients, health care system, and reduced trust between the patients and medical personnel. This study aims to identify the hospital strategies in dealing with patient complaints due to alleged malpractice in digital era. This study conducted the preparation of literature review with systematic technique in selecting and searching using international and national databases. Due to large number of complaints that come in, it is important for hospitals to create a complaint handling system by improving the complaint handling process by preparing professional resources in handling the complaints. The preventive efforts are also needed by increasing awareness about patient safety, implemented the service procedures in accordance with existing SOPs, and filling out the documents properly and correctly such as requesting a letter of approval for action by providing an explanation of procedures and prognosis of treatment.
ELECTRONIC MEDICAL RECORD ACCEPTANCE: A Literature Review
Authors: Soraya Ananda Dhea , Dewanto Iwan , Setyonugroho Winny
Published: January 2025

The implementation of hospital information systems and electronic medical records can improve health care services in hospitals, but there are still many things that inhibits its user acceptance. The purpose of this study is to find out things that can support the acceptance of hospital information systems and medical records by electronic users and their obstacles. This is a literature review research and uses the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) methods.Relevant articles were obtained from PubMed in 1982 to June 2021. Articles were selected if they met the criteria in the form of discussing the acceptance of hospital information systems in the form of electronic medical records in hospitals. The result of this research showed that 1535 articles were obtained from PubMed. The same article was deleted with Zotero's delete duplicate feature and manually with the results of 215 relevant articles, 89 articles were selected through abstract reading and 22 articles were obtained for full text reading.A total of 21 journals were analyzed in this review. Factors that affect the acceptance of hospital information systems and electronic medical records are perceived usefulness, perceived ease of use, human-related factors, demographics and the human environment, technological factors, organizational and organizational environmental factors, effort expectancy and performance expectancy. Implementation of information systems and electronic medical records can be maximized by increasing user acceptance of the system so that health services can be provided optimally.
HAZARDOUS AND TOXIC WASTE (HTW) MANAGEMENT LIABILITY IN THE PERSPECTIVE OF CIVIL LAW
Authors: Prasetyo Dr. Dossy Iskandar , Puspitasari Enggar
Published: January 2025

A person or legal entity can assume responsibility for hazardous and toxic waste (HTW) management. The Environmental Protection and Management Law (UUPLH) aims to protect the environment from pollution, including HTW. This waste is generated from industrial or human activities that pose a great potential for environmental damage and threats to the lives of the living. Therefore, HTW should be managed properly to prevent pollution that endangers the ecosystem. Business actors or communities that are unable to manage HTW independently can seek the assistance of third parties who have expertise in the management of such waste. This collaboration is necessary to assure that HTW is managed effectively, in accordance with applicable regulations, thus avoiding additional risks to the environment and public health. This research aims to increase awareness of the importance of HTW management and the inherent responsibilities of the parties involved. This research adopts a normative juridical approach, which refers to regulations, legal concepts, and relevant literature studies. Drawing on secondary data obtained from relevant literature and regulations related to HTW, this research highlights the importance of HTW management in preventing threats to the environment and ensuring the sustainability of the living environment. The findings of this research suggest that proper HTW management is key to protecting the environment from the dangers of pollution and supporting the sustainability of ecosystems and human welfare in the future.
AN INVESTIGATION OF FACTORS INFLUENCING TOURISTS’ LOYALTY TO REVISIT PHNOM PENH, CAMBODIA
Authors: Sophat IM , Saroeun Associate Prof. Dr. Tan , Hong Assistant Prof. Dr. Soun
Published: January 2025

Phnom Penh, Cambodia’s capital is a popular destination for both domestic and foreign tourists because of its rich cultural legacy, numerous natural and man-made attractions, recreational facilities, retail possibilities, and tourist amenities. This research investigates factors influencing tourist loyalty in Phnom Penh, Cambodia, examining factors influencing tourists’ decisions and loyalty to Phnom Penh as a tourism destination reveals a high crime rate of 62.18% in 2018, with a 73.08% increase over the past of three years. Factors such as E-WOM, brand knowledge, and perceived risk contribute to this issue. Based on the literature, it has been determined that electronic word-of-mouth and destination brand knowledge are the independent variables, while destination brand knowledge is the dependent variable. This research uses a quantitative and correlational research methodology to gather data from 384 respondents using non-probability samplings. Further, the procedure of the statistical analytical tools is conducted using SPSS version 25 and the Analysis of Moment Structures (AMOS) version 23. As the statistical result, the study investigates the relationship between Electronic Word of Mouth (E-WOM), Destination Brand Knowledge, Perceived Risk, and Tourist Loyalty in Phnom Penh, Cambodia. It found a positive correlation between E-WOM and destination knowledge, influencing tourists’ decisions and loyalty. However, it also revealed a negative association between perceived risk and loyalty, suggesting strategies for risk mitigation and trust enhancement. The findings can help policymakers and stakeholders foster sustainable tourism growth and enhance destination competitiveness in Phnom Penh, Cambodia.
Chemical Composition and Sensory Evaluation of Products Made From Oats (Avena Sativa) and Unripe-Plantain (Musa Paradisiaca)
Authors:   Department of Home Science and Management, University of Nigeria, Nsukka, Enugu State, Nigeria, Onyeke Nkechi G. , Onodugo Nkechi G. ,   Department of Nutrition and Dietetics, University of Nigeria, Nsukka, Enugu State, Nigeria, Eze Scholastica N. ,   Department of Nutrition and Dietetics, University of Nigeria, Nsukka, Enugu State, Nigeria, Okoye Linda O. ,   Department of Home Science and Management, University of Nigeria, Nsukka, Enugu State, Nigeria
Published: January 2025

The study accessed the chemical composition and sensory evaluation of products made from oat (Avena sativa) and unripe plantain (Musa paradisiaca). This research aimed to determine the chemical composition of food products made from unripe plantain and oat composite flours and evaluated the acceptability of such foods through sensory evaluation for the benefits of diabetics and obese persons. Proximate, minerals, and phytochemicals analysis were conducted to ascertain the concentration of essential nutrients composition, Unripe plantain and oats flours were mixed at 50:50, 70:30, and 80:20 in ratios of plantain and oats respectively to formulate the composite flours, and analysed to determine the most preferable and recommend ratio based on chemical composition and sensory properties. Composite flour mixes with 50:50 in ratio proved to be the most preferable in sensory evaluation, general acceptability, minerals composition, and the proximate; it is then recommended for the target population. Unripe plantain and oats composite flours when adopted as part of food varieties or food ingredients for diabetics and obese persons can be used to make foods whether as deserts or main meal components of their diets in form of puddings, dumplings, and swallows.
Democracia, proteção de dados pessoais e voto feminino nas eleições brasileiras
Authors: Refosco Helena Campos , Trento Simone , Nascimento Larissa Almeida
Published: January 2025

O artigo trata do histórico da proteção de dados pessoais e de suas especificidades no contexto político e eleitoral brasileiro, conectando os pontos de atenção do tema com a importância pragmática do voto feminino. O objetivo é expor os instrumentos individuais e coletivos para a tutela dos dados pessoais e da lisura do pleito. Na atualização da regulamentação das leis eleitorais, o Tribunal Superior Eleitoral (TSE) explicitou que os direitos dos titulares dos dados pessoais se fazem presentes na seara eleitoral, sendo exigíveis diretamente pelos titulares ou seus representantes perante os controladores dos dados. É também possível a tutela judicial preventiva, especialmente na fiscalização da propaganda eleitoral. A partir de interpretação analógica de importante precedente do TSE, o artigo sustenta que o uso abusivo de dados pessoais, caso constatada gravidade, sujeita a candidatura beneficiária à cassação do registro ou o candidato eleito à cassação do diploma. Conclui-se que a capacitação do eleitorado para a autodeterminação informativa é essencial, mas progressiva; as ações das plataformas são parte fulcral na problemática; à falta de regulação das plataformas, parcerias vêm sendo firmadas pelo TSE; na necessidade de tutela jurisdicional, a Justiça Eleitoral dispõe de ferramentas para tutela preventiva e repressiva.
Genomic and phylogenetic analysis of plant growth-promoting bacteria
Authors: Rodrigues Marcus Vinicius da Silva , Oliveira João Paulo de , Noriler Sandriele Aparecida , Garcia Angelo Barreiro , Pereira Ulisses de Pádua , Rocha Ulisses Nunes da , Oliveira Junior Admilton Gonçalves de , Bressan Glaucia Maria
Published: January 2025

This study aims to analyze the genomic characteristics of a plant growth-promoting bacterium, focusing on genome assembly and annotation, as well as phylogenetic and metabolic analyses. The primary objective is to identify and validate genes related to potassium and phosphate solubilization, as well as other primary and secondary metabolic pathways. The research involves the selection of a strain, cultivation, DNA extraction, sequencing, genome assembly and annotation, followed by phylogenetic and comparative analyses. The analyzed Bacillus nitratireducensLABIM48 strain shows high genomic conservation, indicating a common origin and conserved evolution. Phylogenetic analyses confirmed that the strain belongs to the same mentioned species, with the potential to produce bioactive compounds of interest identified in silico. The ability to solubilize phosphate and potassium was validated through in vitro tests.
Using graph-based structural signatures and machine learning algorithms for molecular docking assessment of histone deacetylases and small ligands
Authors: Cioletti Alessandra G. , Lemos Rafael P. , Santos Lucas M. dos , Mariano Diego , Melo-Minardi Raquel C. de
Published: January 2025

Histone deacetylases (HDACs) are enzymes that play an essential role in regulating gene expression, with recent studies linking their inhibition to autism spectrum disorders (ASD). As a result, there is growing interest in understanding the effects of HDAC inhibition. In this paper, we used molecular docking to investigate the binding between HDACs and small ligands, focusing on two enzymes involved in embryonic development: Histone deacetylase 1 (H1) and Histone deacetylase 2 (H2). Using a graph-based structural signature algorithm, we extracted features from the resulting complexes and employed machine learning algorithms to distinguish natural ligands from decoys, achieving 72% of accuracy in the classification test.
Systemic Scleroderma: Orofacial Manifestations and Therapeutic Approaches
Authors: Bouslama Ghada , Mtiri Aya , Sayda Ben Messaoud Nour , Oualha Lamia , Ben Youssef Souha
Published: January 2025

Systemic scleroderma, a multifaceted autoimmune disease, often presents with significant orofacial manifestations that pose substantial challenges in clinical management. This chapter provides a comprehensive review of the various orofacial complications associated with systemic scleroderma, including microstomia, xerostomia, periodontal disease, and temporomandibular joint disorders. The pathophysiological mechanisms underlying these manifestations are explored, highlighting the importance of early recognition and intervention. Additionally, this chapter discusses current therapeutic approaches, emphasizing the need for a multidisciplinary strategy that encompasses physical therapy, surgical options and prosthetic rehabilitation. This review aims to enhance understanding among healthcare professionals and improve patient outcomes through a more informed and integrated approach to care.
Utilization of Apiary Product for Boosting Human Health
Authors: Roy Subhalaxmi , Kumar Mishra Bijoy , Shastri Pattnaik Manasa , Suparna Mahapatra Sushree
Published: January 2025

Honeybees are vital pollinators that contribute significantly to global agriculture and biodiversity. Their role extends beyond pollination to the production of various valuable products, including honey, beeswax, propolis, royal jelly, and bee venom. Honey, a natural sweetener, and source of bioactive compounds, is renowned for its antimicrobial, antioxidant, and anti-inflammatory properties. It has been used historically for its medicinal benefits and continues to be studied for its potential in treating wounds and digestive issues. Beeswax, a natural wax produced by honeybees, finds applications in cosmetics, pharmaceuticals, and candles owing to its emollient and barrier properties. Propolis, a resinous substance collected by bees from tree buds and used to seal their hives, exhibits antimicrobial and antiviral effects making it a valuable component in traditional medicine and modern health supplements. Royal jelly, a protein-rich secretion used to nourish queen bees, is consumed as a dietary supplement for its purported health benefits, including enhanced immunity and improved skin health. Bee venom, though less commonly utilized, is gaining attention for its potential in treating arthritis and other inflammatory conditions due to its complex biochemical profile. This abstract underscores the significance of honeybees beyond their ecological roles emphasizing the diverse applications and therapeutic potentials of their products, which continue to be subjects of scientific investigation and commercial interest.
Recent Advancement of Nanocrystal Dosage Forms
Authors: Chen Jiayi , Zhao Zhifeng , Yathavan Bhuvanesh , Mirajkar Abdur , Guo Dongwei , Huang Jingjun
Published: January 2025

Drug nanocrystal (NC) is a formulation approach, which has been extensively exploited to enhance drug delivery for application in both dissolution rate improvement and sustained release of poorly water-soluble drugs by size reduction and stabilization of the drug particles. Due to the unique physicochemical and pharmacokinetic properties NCs entail, the versatility to be incorporated into various dosage forms for different disease treatments, and the ease of scalability from laboratory development and optimization setting to commercial production by well-developed manufacturing technologies, NCs have attracted tremendous industrial interest, which is reflected by the increasing financial and research and development effort over the last decade. This chapter intends to overview NCs as a viable drug development approach with the introduction on the important aspects of formulation principles and analytical characterizations. The conventional and novel manufacturing methods are highlighted with an emphasis on scalability of widely used wet milling and high-pressure homogenization technologies. The recent application trends of NCs utilized in the pre-clinical studies and clinical trials are discussed further. In addition, the currently marketed products and the future prospective of NCs are elaborated.
The Supracerebellar Approach for Pineal and Brainstem Lesions: Advantages and Limitations
Authors: Doğruel Yücel , Fikret Sönmez Osman
Published: January 2025

The supracerebellar approach is a crucial surgical technique for accessing pineal and posterior brainstem lesions. Originally introduced by Krause and modified by Stein and Yaşargil, this approach provides a direct operative corridor to the pineal region, posterior third ventricle, and tectum, facilitating the resection of various pathologies, including pineal tumors, astrocytomas, and vascular lesions. The paramedian and lateral variants of the approach offer increased surgical freedom and favorable angles of access, minimizing cerebellar retraction and reducing the risk of postoperative complications. Endoscopic-assisted techniques have improved the approach by enhancing visualization, allowing for minimally invasive procedures, and faster recovery times. However, challenges remain, particularly with the proximity of critical structures like the superior medullary velum and the deep venous system, which can limit the rostral extent of tumor resection. Additionally, intraoperative risks such as venous air embolism are concerns, especially in the sitting or semi-sitting positions. Despite these limitations, the supracerebellar approach remains highly effective and versatile. This chapter examines the anatomical considerations, surgical techniques, and clinical applications of the supracerebellar approach, highlighting its advantages and limitations. Through a comprehensive review of historical perspectives and current advancements, we aim to underscore the significance of this technique in the surgical management of posterior fossa lesions.
Diagnosing Acute Appendicitis in Children: The Role of Diagnostic Scores
Authors: K. Tzortzopoulou Adelais
Published: January 2025

Appendicitis is one of the most common emergency conditions in children. Through inflammation, necrosis, and perforation of the appendix layers, it causes often peritonitis. Recent epidemiological and clinical data support the theory of two distinct pathological entities of appendicitis: simple non-perforated and complicated appendicitis. Simple non-perforated appendicitis in children can be treated successfully with antibiotics in 92% of cases; thus, complicated appendicitis proceeds rapidly to perforation and should be managed with emergency surgery. To approach acute appendicitis, a lot of clinical scoring systems have been created, which are easily applicable to pediatric patients and their parents due to their simple variables consisting of clinical symptoms, physical examination findings, and laboratory data. Clinical score systems (as PAS and Alvarado Score) currently in practice cannot predict which children with appendicitis should proceed directly to surgery. As a result, preoperative ultrasound (US) and/or low-dose CT scan imaging is recommended in all intermediate or high-risk patients in order to diagnose them properly. CoApPS score is a recently presented score that could guide doctors, both experienced and inexperienced ones in emergency management of children with complicated appendicitis reducing hospitalizations and urgent surgeries. A combination of positive jumping-up test, vomiting, White Blood Cell count >13.5 x 10−3/ml, lymphocytes <18% and C-reactive protein >50 mg/dl are the score’s predictors. In this chapter, we will discuss the scores that are nowadays used to diagnose appendicitis in children, focusing on the advantages and disadvantages of each scoring system, and comparing them with each other.
Simultaneous Breast Augmentation with Mastopexy
Authors: Nelson Chase , Cuzalina Angelo , Gutierrez De Pineres Sebastian
Published: January 2025

Breast lift and augmentation are often desired by the female patient to address ptotic breasts. Historically, this was performed with a staged mastopexy followed by augmentation at a later date. More recently, the two procedures have been found to be safely and effectively performed as a single stage procedure. This affords the patient a more cost effective (only one operation and one anesthesia fee) and timely strategy for reaching their esthetic goals. Furthermore, prior literature describes fairly stringent restrictions on implant size. We present our technique of using a superomedial-central pedicle with total submuscular implant placement to achieve appropriate breast position with preserved nipple-areola-complex vascularization whilst having the freedom to place a proportionately sized implant, even relatively large implants if so desired by the patient. The described technique has proven to have extremely durable results leaving the patient with a youthful appearing breast with a propensity to withstand future ptosis and/or waterfall deformity.
Perspective Chapter: Safe Disposal and Storage of Nuclear Waste
Authors: Guo Xiaolei
Published: January 2025

The use of nuclear energy inevitably generates nuclear waste as the byproduct of fission reactions. Depending on the initial composition of the fuel that goes into the reactor and the subsequent burn-up level, the chemistry of the resulting nuclear waste can vary substantially. This waste typically exhibits a broad spectrum of radioactivity and half-lives, making effective management one of the most critical challenges for global nuclear energy. This chapter provides a comprehensive overview of the origin and classification of nuclear waste and various strategies for its safe immobilization and disposal. The short- and long-term storage of waste with varying radioactivity is addressed. The significant technical and political complexities involving primarily long-term disposal are also discussed. To ensure the safe and permanent disposal of hazardous waste with extremely long half-lives, future efforts should focus on both technical innovation and public engagement.
Role of Protein Kinases in Cellular Signaling
Authors: Roland Akinseye Olanrewaju
Published: January 2025

Cellular signaling, a complex language governing life’s essential processes, relies on precise molecular interactions. Central to this intricate web are protein kinases—molecular switches orchestrating vital information transmission within cells. This abstract explores their pivotal role, showcasing their structural diversity, mechanisms of action, and profound implications in health and disease. Protein kinases, a diverse enzyme family, phosphorylate specific substrates, modulating cellular activities by toggling molecular switches. This specificity ensures cells selectively respond to diverse cues, shaping their destiny. In disease, dysregulated kinase-driven signaling, notably in cancer, fuels uncontrolled cell proliferation. Kinase inhibitors have revolutionized cancer therapy, offering precise treatments. Beyond cancer, kinase-targeted therapies extend to autoimmune disorders and neurodegenerative diseases. Personalized medicine leverages kinase insights, tailoring treatments for maximum efficacy and minimal side effects. This chapter explores protein kinases’ multifaceted roles. It delves into their structural diversity, activation mechanisms, and involvement in key pathways such as MAPK, PI3K/Akt/mTOR, and Notch. The future promises system-wide approaches, innovative targeting, and ethical considerations in precision medicine. This chapter immerses readers in the captivating realm of protein kinases, illuminating their roles as architects and translators of cellular communication.
A Survey of Localization in Cognitive Radio Sensor Networks: An Algorithmic Perspective
Authors: Yildiz Dogan , Demirci Sercan
Published: January 2025

The fast expansion of new wireless devices and applications over the last ten years has resulted in a massive increase in the demand for wireless radio spectrums. The existing fixed spectrum assignment strategy hinders efficient spectrum use. Much of the licensed spectrum has been underutilized due to this approach. To solve the spectrum efficiency problem, the idea of Cognitive Radio Networks (CRNs) has gained traction in recent years. Thanks to CRNs, Wi-Fi users can adjust their operational parameters best to suit their interactions with the surrounding radio environment. This paradigm aims to improve spectrum utilization through the dynamic allocation and sharing of spectrum resources. One of the most critical issues affecting the design and performance of traditional networks, such as Wireless Sensor Networks (WSNs), is localization. Location information is crucial for network design as primary users (PUs), key components of CRNs, have priority in using licensed spectrum. The challenge lies in accurately determining the location of sensor nodes within the network and determining the exact location where an event occurs. Precise information about the location of PUs is of great importance in CRNs. In this chapter, the issue of localization in CRNs is discussed in detail from an algorithmic point of view.
Isatuximab (Sarclisa) for Multiple Myeloma
Authors:   Editors from The Medical Letter
Published: January 2025

Isatuximab-irfc (Sarclisa – Sanofi), a CD38-directed cytolytic antibody, has been approved by the FDA for treatment of newly diagnosed multiple myeloma in adults who are not eligible for autologous stem cell transplantation (ASCT). The drug was approved earlier for treatment of relapsed or treatment-refractory multiple myeloma.
Zolbetuximab (Vyloy) for Gastric and Gastroesophageal Carcinoma
Authors:   Editors from The Medical Letter
Published: January 2025

Zolbetuximab-clzb (Vyloy – Astellas), a claudin 18.2 (CLDN18.2)-directed cytolytic antibody, has been approved by the FDA for use in combination with fluoropyrimidine- and platinum-containing chemotherapy for first-line treatment of locally advanced unresectable or metastatic human epidermal growth factor receptor 2 (HER2)-negative gastric or gastroesophageal junction (GEJ) adenocarcinoma in patients who have CLDN18.2-positive tumors. It is the first monoclonal antibody to be approved in the US that selectively targets CLDN18.2.
Crexont — Extended-Release Carbidopa/Levodopa for Parkinson's Disease
Authors:   Editors from The Medical Letter
Published: January 2025

The FDA has approved Crexont (Amneal), an extended-release capsule formulation of carbidopa/levodopa, for treatment of Parkinson's disease (PD), postencephalitic parkinsonism, and parkinsonism associated with carbon monoxide or manganese intoxication. Crexont contains a combination of immediate-release carbidopa/levodopa granules and extended-release levodopa pellets. An extended-release carbidopa/levodopa oral capsule (Rytary) has been available from the same manufacturer for years; the patent for Rytary expires in 2025.
Vyalev — Foscarbidopa/Foslevodopa Subcutaneous Infusion for Parkinson's Disease
Authors:   Editors from The Medical Letter
Published: January 2025

Vyalev (Abbvie), a solution for continuous subcutaneous infusion containing the prodrugs foscarbidopa and foslevodopa, has been approved by the FDA for treatment of motor fluctuations in adults with advanced Parkinson's disease (PD). Vyalev is the first subcutaneously administered product to become available in the US for treatment of PD symptoms. Duopa, a carbidopa/levodopa enteral suspension infused via a nasojejunal tube or percutaneous gastrostomy, was approved in for the same indication 2015.