bluuebunny/crossref_metadata_2025 huggingface dataset:
Uso da vitamina D e efeitos em mulheres no período de menopausa
Authors: Souto Ana Patrícia Silva de , Leite Elizandra da Silva Medeiros , Souza Letícia Maria Freitas , Azevedo Milayne de Oliveira , Araújo Noély Dantas , Almeida Elzenir Pereira de Oliveira , Sousa Milena Nunes Alves de
Published: November 2023

Resumo: Objetivo: Analisar se em mulheres menopausadas o uso da vitamina D em comparação ao não uso reduz os seus efeitos decorrentes do período. Método: Revisão sistemática adotando a estratégia PICO pesquisados nas bases de dados National Library of Medicine, Scientific Electronic Library Online e Biblioteca Virtual em Saúde, em que foi utilizado, em junho de 2020, com os descritores na seguinte combinação: <>, foram aplicados filtros para inclusão e exclusão dos artigos. Em seguida, foi realizada a leitura dos estudos selecionados e a sistematização, de acordo com o propósito do trabalho. Resultados: os achados revelaram que a vitamina D é benéfica para as mulheres em menopausa, pois possibilita redução dos sintomas como o aumento da imunidade em relação às infecções virais, diminuição de internações hospitalares, mulheres mais ativas diariamente dentre outros. Conclusão: Com base nos resultados encontrados, é perceptível os efeitos positivos com o uso da vitamina D, em longo prazo, no que corresponde a amenização dos sintomas nessa fase do climatério.
Qualidade de vida de pacientes portadores de doença renal crônica em terapia hemodialítica
Authors: Augusto Pontes de Paiva Nobre Felipe , Roberta Marques Alves Ingrid , De Góes Ferreira Olivei Manuella Beatriz , Aguila Toledo Miguel , De Lucena Carvalho Fabrício Kleber , Sousa Milena Nunes Alves de
Published: November 2023

A insuficiência renal crônica (IRC) consiste em uma lesão irreversível e que ocorre de forma progressiva. Dessa forma, visto como um tratamento duradouro, a hemodiálise (HD) assume um papel importante e eficaz. Objetivou-se analisar o nível de qualidade de vida de pacientes portadores renais crônicos submetidos à hemodiálise. Foi realizada Revisão Integrativa da Literatura, realizada a partir de buscas na Biblioteca Virtual de Saúde. Inicialmente, foram encontrados 535 artigos e após a utilização dos critérios de inclusão e exclusão, se restringiram em 16 publicações selecionadas em definitivo. Foi constatado nesta abordagem que o nível de qualidade de vida de pacientes portadores renais crônicos submetidos à hemodiálise, em geral, foi insatisfatório (93,75%). A Hemodiálise propicia melhorias na qualidade de vida em longo prazo, mas, não tem conseguido garantir um bom nível de qualidade de vida entre os pacientes hemodialíticos. Então, necessita-se de intervenções que minimizem os efeitos negativos da terapêutica.
Coliform bacteria as components in biofilm of manure effluents
Authors: Pilip L. V. , Syrchina N. V. , Ashikhmina T. Ya. , Kolevatykh E. P.
Published: November 2023

Aim. To study the intraspecific diversity of coliform bacteria represented in microbial communities in biofilms of manure effluents (ME), as well as to evaluate the effect of chemical reagents on the composition of microbial consortia and some properties of bacteria of the genus Escherichia.Material and Methods. Biofilms of ME were obtained under laboratory conditions and their qualitative and quantitative microbial composition studied. H2SO4 and NaOCl solutions were used for entry into ME. The composition of the microbiota was determined by the method of inoculation on nutrient media.Results. The dominant groups of microorganisms in biofilms of ME were obligate and facultative anaerobic bacteria of the genera Clostridium, Bacteroides and Escherichia. The genus Escherichia is represented by E. coli, E. fergusonii, E. hermannii (Atlantibacter hermannii), E. blattae (Shimwellia blattae), E. coli inactive and E. vulneris with varying biochemical activity. Escherichia fergusonii, Escherichia coli inactive and Escherichia vulneris have increased colonization potential, which contributes to the survival of bacterial populations in the bacterial consortium. Bacteria of the genus Escherichia are able to form associations with the facultative anaerobe Proteus vulgaris and the yeast Rhodotorula glutinis. The significant resistance of E. coli to the effects of chemical reagents used to neutralize and eliminate the smell of ME (H2SO4 to pH 5.5±0.1; introduction of 12.5 mg/l of active chlorine in NaOCl) was revealed. ME treatment did not lead to the complete death of E. coli. However, it reduced the concentration by 2 orders of magnitude. The use of these chemicals can reduce the total volume of gases released by 30–40% and reduce the intensity of unpleasant u.Conclusions. The results obtained can find practical application in the development of formulations of biological products to reduce odour and improve the efficiency of rational disposal of animal by-products.
Microplaston artificial polymers in the Miass River and Lake Turgoyak (Southern Urals, Russia) in the early stages of colonisation
Authors: Sapozhnikov Ph. V. , Kalinina O. Yu. , Vostokov S. V.
Published: November 2023

Aim. To identify the composition and features of the spatial structure of microfouling (microplaston) during the early stages of colonisation of the surfaces of artificial polymer films (LDPE) in the natural habitats of the Miass River and Lake Turgoyak (Southern Urals). The early stages of polymer microfouling which create the basis for further complexity of its spatial mosaic are considered, taking into account the surface microlandscape and the possibilities it creates for the location of community components.Materials and Methods. Fragments of polymer films (LDPE) manufactured for household use were collected in the waters of the Miass River and Lake Turgoyak in June 2023. Samples were selected that were exposed in natural reservoirs for at least several months. Analysis of the composition, structure and spatial organization of microplastonic communities was carried out using light and SEM microscopy.Results. The microplaston in the early stages of growth varied significantly among the habitats studied. On LDPE films from the Miass River they were dominated by sessile armored amoebae (Granofilosea: Microgromiidae), attached diatoms (Bacillariophyta: Achnanthaceae, Cocconeidaceae) developed as a mass and encrusting green microalgae (Chlorophyta, Charophyta) were also found. In Lake Turgoyak cortical green microalgae clearly dominated, together with other diatoms (Bacillariophyta: Rhopalodiaceae, Cocconeidaceae). Trichome and coccoid forms of cyanoprokaryotes (Cyanobacteria: Pseudanabaenaceae, Rivulariaceae, Chamaesiphonaceae, Microcystaceae) were also abundant. The colonisation of films by individual species varied among habitats and also depended on the surface microrelief.Conclusion. Analysis of the microplaston of LDPE films in hydrologically different habitats demonstrated the features of early colonisation of these substrates, the biotope‐specificity of the species and spatial structure of communities, as well as the organisation of colonial settlements of a number of species.
New regional industrial policy and environmental problems
Authors: Idziev G. I. , Akhmedova L. Sh. , Bekshokova P. A. , Ataev Z. V.
Published: November 2023

Aim. The need to accelerate the transition to "green" and digital technologies leads to a more active participation of the state in the economy, including through an active industrial policy. In this regard, the main attention should be paid to the development and use of modern methodological approaches to the formation of a new regional industrial policy, taking into account the environmental aspect.Discussion. One of the main sources of pollutant emissions is industrial production. The article analyses the level of emissions of pollutants from industrial enterprises into the atmosphere in Russia as a whole, as well as for the regions that are leading in the growth of emissions into the atmosphere of industrial enterprises and in the growth in the number of polluting enterprises. Based on the analysis, it is concluded that in many regions of Russia industrial policy is carried out inefficiently. The growth of industrial production occurs extensively by increasing the number of enterprises or industries without taking into account environmental consequences and without the use of modern technologies that reduce the negative impact on the environment. An analysis of methodological approaches to the definition of the "new" industrial policy has been carried out and its general principles have been identified.Conclusion. To date, there is no clear definition of the "new" industrial policy, however, in modern scientific literature there are various methodological approaches that differ from the "old" type of industrial policy. The approaches discussed above differ in the emphasis either on the choice of specialisation – what to produce – or on the process by which prioritization and implementation occurs – how to produce.
Agroecological assessment of herbicides application on soybean crops in the central zone of Krasnodar Territory, Russia
Authors: Savva A. P. , Telezhenko T. N. , Suvorova V. A.
Published: November 2023

Aim. Agroecological assessment of herbicides application on crops of soybean variety Arleta in the central zone of Krasnodar Territory.Materials and Methods. The experiments were carried out on the experimental field of the Federal Research Centre of Biological Plant Protection in 2022 according to the methodological recommendations for testing herbicides in agriculture. Herbicides from different chemical classes were used in the experiment. Efficiency was assessed by the difference in weed and soybean grain yield in comparison with the control. The comparative ecotoxicological load of preparations was carried out according to the ecological load and the coefficient of selectivity of action for the soil.Results. Weed species in the experiment were highly effectively suppressed by the herbicides Pulsar, BP, Pivot, VK and a mixture of Bazagran, BP + Zellek Super, and KE (88–98 %). When using Dual Gold, EC, Frontier Optima, EC and Proponit, and EC before the soybean shoots, the biological efficacy was lower. The preparations Pulsar, BP and Pivot, and VK, in comparison with other herbicides, had a lower level of environmental load and a high coefficient of selective action and meet modern safety requirements for the natural environment.Conclusions. In order to protect the environment when choosing herbicides for application on soybean crops in the central zone of Krasnodar Territory, they should be comprehensively selected taking into account the ecotoxicological load of the preparations.
Effect of the biological protection system on the composition of soil microbiota and quality of potatoes in the central agro‐climatic zone of Krasnodar Territory, Russia
Authors: Nekoval' S. N. , Maskalenko O. A.
Published: November 2023

Aim. Assessment of the effect of biological products on soil suppression, biological efficacy, yield and biochemical parameters of potatoes in Krasnodar Territory.Material and Methods. The experiment was carried out on potatoes of the Colomba variety. The biological preparations against potato diseases have been studied. The research was carried out according to generally accepted methods.Results. During the study period, representatives of the genera Alternaria, Fusarium, Verticillium, Cladosporium, Trichoderma, Penicillium, Aspergillus were identified in the complex of soil fungi. When using biological products, an increase in Trichoderma spp. and conditionally suppressive fungi Penicillium spp. and Aspergillus spp. compared with the control and the chemical protection option, by 4.0 and 29.0 times, 1.7 and 1.8 times and 1.4 and 4.5 times, respectively, was observed. The efficacy of the biological products against Alternaria and Fusarium wilt was 73.4–77.7 % in the first year of the research, and 70.0–76.3 % in the second year, which was higher than chemical protection by 3.3–3.8 % and 0.8–2.7 %, respectively. The yield of potato tubers was higher than the control and the chemical protection option by 49.3–10.1 %. The highest content of vitamin C was noted in the biological protection system option. The content of nitrates in all variants of the experiment was within the normal range. The content of starch was higher than the control and the chemical protection option by 1.1–0.2%, respectively.Conclusions. The application of a biological protection system made it possible to reduce the development of Alternaria and Fusarium on potato plants, increase soil suppression, increase yield and improve biochemical indicators.
Evaluation of the polymorphism of the GDF9 and BMP15 genes and their relationship with the reproductive functions of sheep of different breeds
Authors: Gadzhiev Z. K. , Surzhikova E. S. , Evlagina D. D. , Surov A. I. , Shumaenko S. N.
Published: November 2023

Aim. Polymorphism is the result of evolutionary processes and is inherited, associated with biodiversity and modified by natural selection and functions to preserve various forms of population. It is economically advantageous to find genes that can be used in breeding in such a way as to increase the fertility of animals in different natural geographical zones, since the adaptive abilities of organisms are complicated. In this regard, the purpose of this study was to study the genetic potential of sheep of different breeds bred in various ecological and geographical regions of the North Caucasus with pasture-pasture and pasture-stall conditions of sheep breeding.Material and Methods. Genotyping was undertaken of sheep of different breeds contained in various natural and climatic zones of the Republic of Dagestan and the most arid region of Stavropol Territory in the zone of risky agriculture where the climate is sharply continental. Genotyping in the loci of the genes of differential growth factor (GDF9) and bone morphogenetic protein (BMP15) was carried out by PCR-PDRF (polymorphism of the lengths of restriction fragments) by cutting DNA using endonuclease restriction and further analysis of the size of the resulting PCR fragments. The genetic structure of genes has been studied by methods of genetic and statistical analysis of the data obtained.Conclusion. The genetic structure of sheep populations of different breeds bred in the foothills of the Republic of Dagestan and the arid region of Stavropol Territory was studied for the first time. Information obtained on the role of the degree of genetic variability of sheep of different breeds provides data which can contribute to the ecological well-being of herds and the status characterising the signs of multiple birth rates is also determined. This will further improve and significantly accelerate breeding work with livestock, since an important task of further increasing the efficiency of the industry is the reproduction of the herd together with a simultaneous increase in the productivity of animals.
Analysis of polymorphisms in genes associated with milk productivity in red steppe and Caucasian brown cow breeds in two natural‐climate zones (mountains and plain) of Dagestan, Russia
Authors: Ozdemirov A. A. , Khozhokov A. A. , Huseynova Z. M. , Daveteeva M. A.
Published: November 2023

Aim. The unique gene pool of indigenous breeds in the Dagestan Caucasus is threatened by the increasingly widespread use of commercial breeds, which in turn risks narrowing the genetic base necessary to increase and maintain existing genetic diversity. For this reason, our research aimed to study the polymorphism of the PRL, PIT‐1, GH genes in red steppe and Caucasian brown cattle raised in the conditions of Dagestan.Methods. Genotyping of red steppe and Caucasian brown cattle was carried out using PCR‐RFLP methods. Using these methods, genetic analysis was carried out and polymorphism of the prolactin, somatotropin and pituitary‐specific transcription factor genes was studied.Results. As a result of the genotyping of an experimental group of red steppe cattle, it was found that the distribution of two alleles and three genotypes (PIT‐1A and PIT‐1B; PIT‐1AA, PIT‐1BB, PIT‐1AB) of the PIT‐1 gene has a specific character. The specificity of the allelic spectrum of the PRL gene is expressed in the high (0.84) frequency of occurrence of the PRLA allele and low (0.16) frequency of the PRLB allele. This is reflected in the presence of homo‐ and heterozygous genotypes with a frequency of occurrence of 73.0; 23.0; 4.0 %, respectively.Conclusion. Applied genetic approaches to improve the productive and breed qualities of livestock, which are modern and based on a more complete analysis of the genetic diversity and genotype of the studied populations, contribute to the conservation of zoned breeds. At the same time, intrapopulation variability and good adaptability should ensure the sustainable development of dairy cattle breeding in various climatic zones.
Modeling the social responsibility of the hospitality industry as a factor of sustainable development of a travel destination of the Kaliningrad region, Russia
Authors: Korneevets V. S. , Semenova L. V. , Yakovenko N. V.
Published: November 2023

Aim. To substantiate approaches to the modeling of the social responsibility of the hospitality industry as a factor of sustainable development of a travel destination.Material and Methods. System analysis theory, economic-statistical method, comparative-descriptive analysis and general scientific methods of empirical research were used to process the initial information and to write the paper. The empirical grounding of the proposed model was based on a survey of the population which had experienced accommodation facilities, on questions about social responsibility and on changes in consumer habits.Results. The authors have identified and characterised the main approaches to modeling social responsibility of the hospitality industry as a factor of sustainable development of a travel destination. A model of corporate social responsibility of a local hotel cluster, which focuses on improving the quality of the hospitality industry, the introduction of energy-efficient and convenient technologies, as well as the development of socio-cultural and tourist infrastructure which contribute to the growth of the social infrastructure of the business, is proposed.Conclusion. The universal nature of the structure of the proposed model, allows the extrapolation of the main results concerning the system of the hospitality industry not only in the Kaliningrad region, but also in other regions of the Russian Federation.
An elaboration of obstacles and perspectives of medical tourism development taking the approach of integrated service provision (Case study: Isfahan Province, Iran)
Authors: Hosseini S. S. , Taghvaei M. , Ataev Z. V.
Published: November 2023

Aim. The intention of the present research has been to examine and evaluate the barriers and limitations to the development of medical tourism in Isfahan as one of Iran’s tourism destinations by taking the approach of service integration.Materials and Methods. This exploratory research was conducted using mixed qualitative and quantitative methodology. Data analysis by the qualitative method was done using MAXQDA-18 software, while by the quantitative method a combination of SWOT strategic planning technique and multi-criteria decision making was usedResults. Multiple weaknesses and challenges were classified by using a framework of indexes developed on different dimensions including: quality of medical services and facilities; access to medical and tourism information; infrastructures and regulations; communications and marketing; environmental factors; treatment procedures and passive defense and international barriers. Meanwhile, the role of each of these dimensions and sub-indexes in impeding medical tourism development in the region was evaluated by examining the association between the various dimensions contributing to medical tourism development in Isfahan.Conclusions. To remove the barriers identified, several strategies are proposed. including the provision of health-based integrated services (medical, treatment and wellness), development of shared products by the sectors involved in this domain, compilation of a comprehensive plan for health tourism development, preparation of a coherent and well-organized scientific plan given the policies of resilient economy, realistic and practical attention to the branding issues, the usage of up-to-date methods of modern marketing plan for the health companies and facilitators, removal of the legal barriers to the medical tourism development and compilation of new supportive, supervisory and advertising policies.
The telomerase effect. Oncological aspects of gastric stump cancer (methodology and literature review)
Authors: Aliev S. A. , Gasanguseinov Zh. A. , Omarov K. H.
Published: November 2023

Aim. To assessing the prospects for the integral interdisciplinary characteristics of the modern strategy of oncological surgery for gastric stump cancer (GSC), which allow us to formulate the concept of a more physiological surgery.Materials and Methods. The study used gastrobiopsies taken specifically during fibrogastroscopy in the area of the anastomosis in patients who had undergone gastrectomy in the past for pyloroduodenal ulcers using the first and second Billroth methods. Depending on the time elapsed after gastrectomy, observations were divided into 2 groups.Results. In 45 patients with post‐resection gastritis (based on a morphometric, statistical study of the lymphoid tissue of the mucous membrane of the gastric stump), there was established: a significant (p <0.05) increase in the number of interepithelial lymphocytes (from 5.14 to 30.60) of the plasmatization index of the lamina propria of the mucous membrane in comparison with the control group (from 4.9 to 46.70), increasing in time after surgery, which is associated with the progression of atrophic gastritis. This relationship is most clearly observed (p<0.005) over 15 years after gastrectomy, according to Hoffmeister–Finsterer.Conclusions. A study of the components of the natural environment was carried out: sources of drinking water supply: phenol, manganese, copper, formaldehyde and in samples of pasture vegetation: iron, chromium, nickel, cadmium; with the establishment of inflated indicators (MPC). Early diagnosis in the preclinical stage with screening monitoring in the group of patients with resected stomach after 10 years or more remains extremely relevant. The hypothesis put forward by Yu.I. was confirmed to be correct by Fishson–Ryss that antral gastritis after gastric gastritis for peptic ulcer disease tends to antrocardial expansion with the progression of atrophic gastritis, which is a background component for the development of gastric stump cancer.
Replenishment of the species composition of the bioresource collection of Entomoacariphages
Authors: Ignatieva T. N. , Kashutina E. V. , Bugaeva L. N. , Khetagurova E. V.
Published: November 2023

Aim. Formation of the species composition of the bioresource collection "State Collection of Entomoacariphages and Microorganisms" of the Lazarev Experimental Plant Protection Station – a branch of Federal Scientific Centre for Biological Plant Protection. The collection is based on species identified in local biocenoses as well as those introduced from regions with similar climatic conditions.Material and Methods. Collection and study of the effectiveness of native, invasive, introduced entomophages, the dynamics of their acclimatization and the possibility of their introduction into laboratory culture on the territory of the Black Sea coast of Sochi. Methods of their application in plant protection systems were tested.Results. The ability of Cryptolaemus montrouzieri Muls. to control the number of coccids, including Icerya purchase Maskell, has been experimentally established. Entomophages which are effective and adaptable to reproduction in laboratory conditions were selected: Dicyphus errans Wolff. and Macrolophus nubilis H.S., the aphidophage Harmonia axyridis Pall. and others.Conclusion. As a result of the study, wide polyphages of Dicyphus errans Wolff were found to be presented in the collection of the Lazarev Experimental Plant Protection Station, as well as and Macrolophus nubilis H.S., Cryptolaemus montrouzieri Muls., Leis dimidiata Fabr., Harmonia axyridis Pall., Encarsia partenopea Masi and Lysiphlebus fabarum Marsh. Acariphages are represented by Phytoseiulus persimilis Ath.‐Henr. and Amblyseius cucumeris Ond. The biological efficacy of Encarsia partenopea Masi has been evaluated in relation to Trialeurodes vaporariorum Westw. in the conditions of the protected ground of Sochi at the parasite ratio:host of 1:30; 68.6%, the best result being obtained with releases of 1:10; 79.19%. Research has begun on the development of methods for the laboratory breeding of Chilocorus renipustulatus.
Radon gas in indoor air of primary schools of Al-Najaf city, Iraq
Authors: DOSH Rukia Jabar , HASAN Ali K , ABOJASSİM Ali
Published: November 2023

The indoor radon concentration of 100 primary schools in Al-Najaf province, Iraq, was measured to determine students’ and staff's safety in these schools using a CR-39 nuclear track detector based on the sealed can improve technique. The results of indoor radon concentration for all schools vary from (7.47 to 44.84) Bq / m3 with an arithmetic mean (AM) of 22.26 Bq /, while the geometric mean (GM) was 20.67 Bq / m3. The concentration of 222Rn was lower than the worldwide level. Some radiological parameters like annual effective dose (AED), potential alpha energy (PAEC), exposure to radon progeny (EP), and lung cancer cases per year per million people (CPPP) were also determined. The results of these parameters point toward normal levels in the primary schools, according to ICRP, UNCER, and NCRP data.
Relationship of comorbidity and platelet function in patients with unstable angina
Authors: Nedbaeva D. N. , Sirotkina O. V. , Mineeva E. V. , Vasilyeva E. Yu. , Morozova E. I. , Vavilova T. V. , Kukharchik G. A.
Published: November 2023

Background. Platelets play a key role in the pathogenesis of acute coronary syndrome (ACS). In recent years, the amount of data on the advisability of using the platelet function test (PFT) in the appointment of antithrombotic therapy has been growing.

Objective. To access PFT in patients with unstable angina and various comorbidities.

Design and methods. The study involved 74 patients with the diagnosis of unstable angina. All patients underwent standard clinical examination, PFT (impedance aggregometry with ADP and collagen), assessment of Charlson comorbidity index.

Results. The most frequent comorbidities were: hypertension (95 %), type 2 diabetes mellitus (30 %), excessive body weight (35 %), multifocal atherosclerosis (22 %), smoking (24 %). Half of the patients (n = 36) had high level of comorbidity. Patients with a comorbidity index of 5 or more had high platelet aggregation on the 3rd day of hospitalization. Elderly patients, smokers, as well as patients with diabetes mellitus type 2 and multifocal atherosclerosis also had higher values of platelet activity, which may be associated with unfavorable prognosis and risk of recurrent events.

Conclusion. We revealed association between PFT and comorbidities both with risk factors or diseases alone and in its integral assessment using the Charlson comorbidity index. Among the individual risk factors, smoking, diabetes mellitus and multifocal atherosclerosis were the most important, which confirms their direct role in the pathogenesis of thrombotic complications.
Results of myocardial revascularization in patients with acute coronary syndrome and COVID-19: experience of the urban multidisciplinary hospital
Authors: Vorobevskii D. A. , Vildanov T. R. , Korepanova A. I. , Scherbak S. G. , Vlasenko S. V. , Plechev V. V. , Lazakovich D. N. , Osadchii A. M.
Published: November 2023

Background. The 2019 novel coronavirus pandemic has had a significant impact on the prognosis and outcomes of patients with acute coronary syndrome (ACS).

Objective. Study of the impact of a new coronavirus infection (NCI) on the nature of the course and outcomes of the disease in patients with ACS.

Materials and methods. The study included patients with ACS and a positive test for COVID-19 upon admission to the hospital in the period from April 2020 to August 2021.

Results. The study included 107 patients. Among patients with and without ST elevation with more than 50 % lesions (n = 10; n = 10), 8 patients died, which was 80 % in each group. In the group with and without ST elevation with less than 50 % involvement (n = 20; n = 67), 5 and 8 patients died, accounting for 25 % and 11.9 %, respectively. The role of the influence of the levels of Il-6 (interleukin-6), troponin T and creatinine on the course and outcomes of the patients’ disease was analyzed.

Conclusion. COVID-19 infection, namely the degree of damage to the lung tissue, significantly worsens the course and outcomes in patients with both NSTE-ACS and STE-ACS. Further accumulation of clinical experience in endovascular treatment of ACS and the development of algorithms for providing medical care to patients with ACS in the context of COVID-19 is required.
Technical aspects of hybrid interventions for multilevel lesion of brachiocephal arteries. Literature review
Authors: Vanyurkin A. G. , Belova Yu. K. , Chernov A. V. , Tarasova O. S. , Verkhovskaya E. V. , Vlasovets A.  A. , Suslov S.  S. , Chernyavsky M. A.
Published: November 2023

Carotid artery stenosis is one of the leading causes of ischemic strokes and accounts for about 20 % of all strokes. The widespread use of radiological diagnostic methods and recommendations for the carotid artery stenosis patients management led to the identification of atypical forms of damage to the brachiocephalic arteries — a combination of multi-level stenoses of extra and intracranial localization. Multilevel lesion of brachiocephalic arteries is characterized by a combination of hemodynamically significant stenosis of the internal carotid artery in combination with stenosis of the common carotid artery or brachiocephalic trunk. The prevalence of tandem lesions varies from 0.5 to 6.4 %. Despite the rarity of this pathology, the risk of ischemic complications against the background of tandem stenosis of the brachiocephalic arteries is higher than with a single-level lesion. The surgical intervention strategy should provide for the correction of both stenosis, which can be achieved in three ways: endovascular method, open prosthetics and hybrid method. The essence of the hybrid technique is the simultaneous correction of the distal and proximal zones of stenosis by one surgical team in a hybrid operating room. The aim of the study is to review the available literature data and to demonstrate the developed hybrid intervention technique with a detailed description of the technical aspects of all stages of the surgery.
“Epilepsy 90–80–70”: The Intersectoral Global Action Plan on epilepsy and other neurological disorders (2022–2031)
Authors: Odintsova G. V. , Abramov K. B. , Ivanova N. E. , Samochernykh K. A. , Khachatryan V. A. , Konradi A.  O. , Zabrodskaya Ju. M. , Dengina N.  O.
Published: November 2023

Epilepsy is one of the oldest known nervous system disorders and imposes enormous physical, psychological, social and economic burden on individuals, families and countries due to misunderstanding and stigmatization. These problems are most relevant for developing countries, where up to 85 % of epilepsy patients live. Despite the fact that it is a treatable and preventable disorder, there is a lack of adequate public awareness and understanding of the problems of epilepsy. This article is devoted to the Intersectoral Global Action Plan on epilepsy and other neurological disorders (IGAP) 2022–2031, adopted on 27 May 2022 at the 150th session of WHO’s Executive Board. It provides data on the public and medical importance of epilepsy, the history of the joint initiatives of WHO, the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE) aimed at reducing the burden of epilepsy on society and improving public knowledge about neurological disorders. The key provisions of the Intersectoral Global Action Plan on epilepsy and other neurological disorders 2022–2031 are announced. The Epilepsy 90–80–70 cascade target, launched by ILAE and IBE, is presented to inspire decades of action and significantly improve care and treatment for all people living with epilepsy worldwide. The final section is devoted to the evolution of epileptology at Almazov National Medical Research Centre, its present and its prospects.
Clinical case of combined genetic pathology in a child with jaundice syndrome
Authors: Krylova I. A. , Malyavskaya S. I. , Levitskyi S. N. , Toropygina T. A. , Turabov I. A.
Published: November 2023

Diagnosis of a combined genetic pathology that occurs with jaundice syndrome is a difficult task, because of common clinical manifestations for several diseases having different genesis and requiring specific diagnosis and treatment tactics. Icteric staining of the skin due to hyperbilirubinemia at any age requires immediate examination to establish its genesis and differential diagnosis between infectious and non-infectious diseases. The spectrum of diseases accompanied by jaundice syndrome includes more than 50 different diseases. The main mechanisms of suprahepatic jaundice are: firstly, a violation of the capture and glucuronidation of bilirubin in the liver, and secondly, an increased destruction of red blood cells due to hemolysis or during the disposal of blood during internal bleeding. The first mechanism is realized in Gilbert’s syndrome, while the second mechanism of suprahepatic jaundice is often due to hemolytic anemia.

In presented clinical case, the implementation of two pathogenetic forms of jaundice in one patient is shown — suprahepatic, caused by type 2 hereditary stomatocytosis and Gilbert’s syndrome, as well as obstructive jaundice, caused by cholelithiasis. The special attention should be paid to precise patient examination, if disease manifestations are not consistent with classical clinical picture. The use of a new generation sequencing method, along with traditional diagnostics methods, made it possible to establish an accurate diagnosis and determine the tactics of patient management.
Checking the power of the mathematical model with a computer program to determine the probability of developing congenital pneumonia in premature newborns with very low and extremely low birth weight
Authors: Harachka A. N.
Published: November 2023

Background. In the age of modern technologies, the relevance of preventive and personalized medicine is growing, therefore, the identification of preclinical markers of the disease is a priority.

Objective. Checking the power of a mathematical model with a computer support program to determine the probability of developing congenital pneumonia in premature newborns with very low and extremely low birth weight.

Design and methods. Based on the results of a comprehensive examination of 113 premature newborns with very low and extremely low birth weight, a mathematical model was developed (z = –4.59+2.54RFIII+2.40CVAF+1.83HCDH+ 1.81Asphyxia+1.66CCLP+0.86TP+0.74CRP+0.48CPIN)) with a computer support program to determine the likelihood of developing congenital pneumonia (http://pneu.bsmu.by ; https://www.bsmu.by in the Doctor menu/Pharmacist: “Diagnosis of congenital pneumonia”). The power test was carried out with an additional set of 58 premature newborns with very low and extremely low birth weight, not included in the resulting model.

Results. The following data were obtained: sensitivity equal to 0.95, specificity — 0.90, prognostic significance of a positive test result — 0.95, prognostic significance of a negative test result — 0.90, likelihood ratio — 9.93.

Conclusion. The results of external validation indicate the high power of the proposed model with a computer support program for determining the likelihood of developing congenital pneumonia in premature newborns with very low and extremely low birth weight.
Characteristics of the health of children and adolescents in the regions of the Far North and areas equated to the regions of the Far North (using the example of the Komi Republic)
Authors: Uzkaya A. A. , Kampov I. V. , Sannikov A. L.
Published: November 2023

Background. Children living in the Far North and areas equated to it are exposed to the climate with insufficient insolation and unstable weather. The lifestyle in the North also contributes to the health, which leads to a high incidence and disablement.

Objective. To analyze the incidence of the children aged 0–14 years in the Komi Republic from 2013 to 2021.

Design and methods. The research material was the database of the “Republican Medical Information and Analytical Center” and the Federal State Statistics Service from 2013 to 2021. A trend line is used to illustrate trends. The value of the approximation reliability R2 is calculated, the values of which indicate the degree of coincidence of the calculated line with the data.

Results. The leading place in the structure of childhood morbidity in the Komi Republic is occupied by respiratory diseases, injuries, poisoning, diseases of the skin, infectious and parasitic diseases. In all cases the rate of primary disease incidence, infant mortality and disability in the Komi Republic exceeded that in Russia.

Conclusion. Severe climatic conditions in Komi Republic are one of the risk factors for the deterioration of children’s health in almost all nosologies.
DIMENSIONES CULTURALES DE LOS EFECTOS DE LA PANDEMIA DE LA COVID-19 EN DOCENTES UNIVERSITARIOS EN CENTROS EDUCATIVOS DE COLOMBIA Y MÉXICO
Authors:   Universidad Libre, Parra Osorio Liliana
Published: November 2023

The sudden change generated at the time of the context of the Covid -19 pandemic, in university teachers led them to experience changes as a result of confinement where it implied the development of their academic work from another context and making use of other forms and strategies. educational technologies. Objective: To analyze the cultural dimensions of the effects of the COVID-19 pandemic on university teachers from three educational centers in Colombia and one in Mexico. Methodology: study design: cognitive cultural anthro- pological, focuses on analyzing how people from different cultures acquire information about the world, how they process it, make decisions and act in ways considered appropriate for other members of their culture (cultural transmission). It is developed in four university centers in Colombia and Mexico, 160 teachers are studied in the first phase of the study through free listings through an open online survey. Findings: the term work overload was included in the four participating sites, with the greatest weight in Bogotá and Cali (Colombia). And in the personal, the presence of COVID-19 itself, negative emotional states, and economic-so- cial effects resulting from prevention measures were highlighted. Also, in complex processes of adaptation, learning and transformation in the use of technological teaching media. Conclusions: the confinement, the uncertainty of the disease, the presence in their families and the changes in the work-family context generated an impact on their professional, personal, economic and social spheres in the teachers of the studied university centers in Colombia and Mexico.
Evaluation of pollution with some heavy metals for soils and plants
of agricultural Locations in Basrah province
Authors: J. Fakher Salwa , S. Bedeeh Riyadh
Published: November 2023

To Evaluate the state of pollution with heavy metals (Zn, Cr, Cu, Ni, Pb), ten Locations with different chemical and physical properties were selected from the agricultural Locations of Basrah province: 1/Al-Qurna, 2/Al-Madina, 3/Al-Dair,
4/Al-Haritha, and 5/Karmat Ali (University). ), 6/ Al-Tanuma, 7/ Abu Al-Khasib,
8/ Al-Siba, 9/ Al-Faw and 10/ Al-Zubayr (Al-Burjisiya station) and a site was chosen for comparison, where soil samples were collected from agricultural Locations
close to the source of pollution, while plant samples were collected from near and
far from the source Pollution and the necessary analyzes were Carried out for the
study. The results showed an increase in the concentration of total heavy metals in
the soils of most of the study Locations, and they were polluted compared to the
comparison treatment. The soils of most agricultural Locations exceeded the internationally permissible limits. The results indicated that the total average concentration of lead, Nickel, copper, chromium and zinc in the Hartha area (the fourth
site) was 615.88, 165.55, 390.40, 48.45, 465.83 mg kg-1
soil sequentially, which is
higher compared to the average concentration in other agricultural sites, as well as
the concentrations of heavy metals increased (Pb, Ni, Cu, Cr, Zn) in plants grown
in locations close from the source of pollution. The concentrations of these elements decreased in plants far from the source of pollution. It is noted that the pollution factor (CF) values of Pb and Zn in all study Locations ranged from moderate
contamination to very high contamination.
Keywords: PLI, pollution Factor (CF), oil installations, soil pollution, plant pollution.
Effect of adding two levels of dried Molokhia (Corchorus Olitorius
L.) leaves to the diet on some physiological characteristics and
bacterial numbers in the intestines of broilers
Authors: A. Hoshi Abbas , Al-Shamire Jinan S.
Published: November 2023

This study has tackled the poultry field of (Abu Ghraib site) related to the animal
production Department/ College of Agricultural Engineering Sciences/ University
of Baghdad for 42 days (from 15 Oct 2021 to 26 Nov 2021). The study aims to
investigate the effect of adding the powder of Corchorus olitorius dried leaves to
the diet for different periods on the productive performance of broilers. Three hundred fifteen broiler chicks are used (Ross 308 breed) regardless of gender, of one
day age and an initial weight of 40 gm. The chicks are divided into seven coefficients and three replicators for each coefficient; each replicator includes 15 chicks.
The chicks starting from age 1-21 days are fed with a (starter) chicken feed consisting of 3006.5 kilo calories/ Kg. Feed metabolized energy and 22% raw protein.
Then, the chicks are fed with a (finisher) chicken feed from 22-42 days of age. The
finisher comprises 3171.11-kilo calories/ Kg. of feed metabolized energy and
20.54 raw protein. Biochemical tests reveal no effect of the coefficients of adding
powder of Corchorus olitorius L. dried leaves on the averages of glucose and phosphorus in blood serum. An improvement (P˂0.05) of T4 coefficient covering albumin, globulin, cholesterol, and whole averages of protein is shown. As for glutathione, all adding coefficients show improvements (P˂0.05) compared to the control coefficient. Coefficient T7 (5.47mg) shows a more significant increase,
whereas the lowest is (4.14mg/ml). The results indicated that treatments of adding
dried Molokhia leaves powder led to a significant (P < 0.05) increase in the number
of Lactobacillus beneficial bacteria compared to the control treatment. In contrast,
a significant (P < 0.05) increase was observed in the number of pathogenic bacteria, E. coli, for the control treatment compared to addition treatments for all periods.
Keywords: chicken feed, dried leaves, molokhia, physiological traits, lactobacillus.
Genotoxicity evaluation in workers occupationally exposed to the
pollutants of Dhi- Qar oil refinery
Authors: Alaa Toama Mariam
Published: November 2023

Background: Workers are occupationally and environmentally exposed to diverse
forms of xenobiotics as gases and vapors. Career publicity to those compounds
can trade the prooxidants/oxidants and antioxidants equilibrium throughout oxidative toxic stress (OTS). Pollutants might also cause genotoxicity by oxidative
DNA. This work was conducted in AL-Nasiriya at the Thi-Qar Oil refinery in
Thi-Qar province, south of Iraq. Samples have been amassed from the refinery
workers and Campus college students and workforce as control. Seventy blood
samples from the refinery people running within the asphalt, laboratory, and refining units and samples from Campus students and staff as control have been
collected. The 8- OHDG was measured using the ELISA technique. The serum 8-
OHdG of refinery workers was notably higher than that of individuals of control
subjects (p< 0.001*). A higher level of serum 8-OHdG was quantified in the
blood samples of all exposed subjects. The significant feature that resulted in an
enhanced genotoxic potential was the years of exposure to the oil refinery environment, which led to an increase in the 8-OHdG formation.
Keywords: Genotoxicity ; workers occupationally ; pollutants ; Dhi- Qar ; oil refinery
Financial Management Mechanisms of Tabuk City Local Government Unit Employees amidst COVID 19
Authors: Gallema – Domingo Dianne
Published: November 2023

Financial stress is one of the challenges that everyone would like to win because prevailing over it results in a more peaceful life. Filipinos are renowned for their resilience in the face of adversity, as we can still smile despite all of life's challenges. Everyone has been touched spiritually, emotionally, physically, and financially due to this massive pandemic, and the war against it appears endless. Since day one, financial stability has been the number one concern, which is why the government has attempted to increase the people's demands. This quantitative and qualitative study examined the financial management system that these employees implemented to combat fatal infections. More than three hundred twenty-four randomly selected respondents completed the structured questionnaire, were interviewed, and provided photographic documentation for data collection. The majority of employees' budgets and savings were moderately affected, according to the research. It was also determined that there were no statistically significant differences between the effects of the pandemic and employment status, wage range, source of money, and purchasing techniques. In addition, the staff engaged in gardening, farming, earning a living, and accepting part-time activities such as pedicure manicures, artificial insemination of large animals, and tutorials, with a strong emphasis on online selling. However, additional interviews revealed that most needed to be financially prepared for the lockdown, as mentioned above. They resulted in additional borrowings because most were financially unstable and spent more than they had saved. Therefore, it is suggested that an extended program on proper financial management be considered to address the preparedness of this personnel for future crises. In addition, a lesson has been learned through the lengthy absence, which is to spend more time with family and friends because we never know what the next day will bring.