bluuebunny/crossref_metadata_2025 huggingface dataset:
Español para traductores en formación: esbozo de una propuesta
Authors:   Departamento de Línguas Estrangeiras e Tradução (LET), Instituto de Letras (IL), Universidade de Brasília (UnB), Cebey María del Mar , Escalante Alba ,   Departamento de Línguas Estrangeiras e Tradução (LET), Instituto de Letras (IL), Universidade de Brasília (UnB), Ramos-Nogueira Luis Carlos ,   Departamento de Línguas Estrangeiras e Tradução (LET), Instituto de Letras (IL), Universidade de Brasília (UnB)
Published: July 2022

Hace más de una década, en la ocasión del Primer Congreso de Traductores Públicos de Uruguay (CTPU 2011), presentamos algunas reflexiones que retrataban el trabajo recién emprendido en el curso de traducción español de la Universidade de Brasília, Brasil. Era el comienzo de nuestro curso y, en ese momento, nuestra experiencia docente provocaba más preguntas que respuestas. Uno de los temas que protagonizaba las discusiones se refería al abordaje de las clases de lengua en un curso de formación para traductores. Como menciona Beeby (2004), los fundamentos para la enseñanza de idiomas en el contexto de la formación de traductores suponen estudiar cada caso en su particularidad. El objetivo de esta propuesta es presentar las ideas que fuimos esbozando para responder a nuestras interrogantes sobre la especificidad de la enseñanza de ELE en el contexto específico de la formación de traductores en el par lingüístico español-portugués. Tales ideas son presentadas de forma inicial, seguidas de algunos de los aspectos que particularizan nuestra propuesta, el contexto de su realización y, a modo de ilustración, un conjunto de actividades didácticas.
Association between Serum Liver Enzymes and Cardiovascular Diseases: A Case-control Study among Adults with Cardiovascular Disease
Authors: Yadav Naval Kishor , Pokharel Daya Ram , Mahaseth Dipak , Kathayat Goma , Sigdel Manoj , Hussain Imran
Published: July 2022

Introduction: Cardiovascular Diseases (CVDs) are the leading cause of global morbidity and mortality. However, their prevalence is disproportionately distributed, with the highest rate in lowincome countries, moderate in middle-income countries, and the lowest in high-income countries. Several studies conducted elsewhere have identified that certain liver enzymes in serum could predict incident CVDs in adults. Aim: To explore the association between liver enzymes and CVDs in adults. Materials and Methods: This was a hospital-based casecontrol study conducted at Manipal Teaching Hospital, Pokhara, Kaski, Nepal, from January 2018 to December 2021among 400 adult subjects (200 healthy controls and 200 CVD patients). Socio-demographic, physiological, and biochemical variables were collected with structured questionnaires and appropriate standardised and validated measurement methods. The p-value (two-tailed) <0.05 was considered statistically significant. Results: The frequency of smoking (p<0.001 and drinking habits (p<0.001), and mean values of Body Mass Index (BMI) (p<0.001), and Systolic Blood Pressure (SBP) (p=0.006), Wait Hip Ratio (WHR), Aspartate aminotransferases (AST), Alanine aminotransferases (ALT), Alkaline phosphatase (ALP), Fasting Blood Sugar (FBS), Glycated Haemoglobin (HbA1C), Creatine Kinase MB (CK-MB), Troponin I (TpI), Total Cholesterol (TC), and Triglyceride (TG) were significantly higher (p<0.001) in CVD patients than in healthy controls. The High Density Lipoprotein Cholesterol (HDL-C), on the other hand, was significantly lower in CVD patients. Only the AST showed significant correlation with the cardiac markers CK-MB and TpI. Logistic regression analysis revealed that aminotransferases was the best predictor (due to differences in odd’s ratio) than ALP for incident CVDs in the adult population. Conclusion: Present study verifies that aminotransferases, particularly AST, was significantly associated with the incident CVD and thus could potentially be measured together with established cardiac biomarkers for the staging and differential diagnosis of CVDs in Nepali adults.
Anaesthetic Management in a Patient of Goldenhar Syndrome Posted for Drainage of Brain Abscess with External Ventricular Drain Insertion
Authors: Shankar Shilpa , Chakole Vivek , Sonkusale Manish , Dalal Shivani , Patil Bhakthi
Published: July 2022

Goldenhar syndrome or Oculo-auricular Vertebral Dysplasia (OAVD) is characterized by a wide range of congenital anomalies including ocular, auricular, facial, cranial, vertebral and cardiac abnormalities. Facial and oral abnormalities especially mandibular hypoplasia, micrognathia, high arch palate and limitation of neck movements resulting from vertebral anomalies, the difficult intubation, laryngoscopy and mask ventilation were expected. Hereby, presenting the case report of a 6-year-old male child, known to have goldenhar syndrome, who underwent drainage of left sided brain abscess with external ventricular drain insertion. In view of the anticipated difficult airway and cardiac anomalies, careful preoperative evaluation, preparation and well formulated contingency plans for airway maintenance, endotracheal intubation and intraoperative haemodynamic is required to combat the perioperative anaesthetic challenges in all cases of goldenhar syndrome.
Effect of Bispectral Index versus End Tidal Anaesthetic Gas Concentration on Time to Tracheal Extubation for Isoflurane Based General AnaesthesiaA Prospective Observational Study
Authors: Jain Shalini , Pandya Ravina , Arora Kishore Kumar , Gupta Neetu
Published: July 2022

Introduction: Modalities like Bispectral Index Monitoring (BIS) and End Tidal Anaesthetic Gas (ETAG) concentration guided anaesthesia have been used to study the intraoperative awareness but their efficacy for achieving early tracheal extubation has not been established. Aim: To compare the effect of BIS monitoring and ETAG concentration guided anaesthesia on time to tracheal extubation and haemodynamics for isoflurane based general anaesthesia. Materials and Methods: This prospective observational cohort study was conducted in the Department of Anaesthesiology at Mahatma Gandhi Memorial Government Medical College and MY Hospital, Indore, Madhya Pradesh, India, from June 2020 to June 2021. Total 60 patients with American Society of Anesthesiologists (ASA) status I and II who received isoflurane based general anaesthesia were included in study. Depending upon the modality being used by the anaesthesiologist to monitor and maintain the depth of anaesthesia, the patients were allocated in equal numbers into two group. Group B received BIS guided anaesthesia, where BIS value was kept between 40 and 60 and group E received ETAG concentration guided anaesthesia, where Minimum Alveolar Concentration (MAC) was kept between 0.7 to 1.3. Tracheal extubation time was recorded from stopping all anaesthetic agents upto the time of extubation. Unpaired t-test was applied for analysis of data. Results: The mean tracheal extubation time was significantly longer in the BIS group (21.14±2.23 minutes) as compared to ETAG group (15.20±1.27 minutes). All hemodynamic parameters i.e., pulse rate, mean arterial pressure and saturation remained within normal limits and were comparable between the two groups at all the time intervals. Conclusion: The tracheal extubation time is significantly longer in BIS guided anaesthesia as compared to ETAG guided anaesthesia. The ETAG monitoring promotes earlier extubation of patients as compared to BIS monitoring in isoflurane based general anaesthesia.
Effect of Nano Zeolite, Nano Micronutrients and Biocapsules on Plant Growth, Head Yield and Quality of Broccoli (Brassica oleracea var Italica)
Authors: Priyanka Teegala Sharon , Kerketta Anita , Topno Samir E. , Mohiddin Shaik Gouse , Tripathi Pratyasha
Published: July 2022

The present investigation was conducted at the Vegetable Research Farm, Department of Horticulture, Naini Agricultural Institute, Sam Higginbottom University of Agriculture, Technology & Sciences (SHUATS), Prayagraj (U.P.), during the Rabi season of the year 2020–21. The experiment was laid out in a randomised block design with three replications and 15 treatments. T15 N P K (RDF) + Nanozeolite 50 ppm (Soil drenching)+ Biocapsule 500 ppm+ folia application of ZnO and FeO nano particles & T13 N P K (RDF) + Biocapsule 500 ppm (soil drenching) + foliar application of ZnO and FeOnano particles was found to be the best in Plant height, leaf area, and no of leaves. Again In terms of yield parameters, the treatment T15 N P K (RDF) + Nanozeolite 50 ppm (Soil drenching) + Biocapsule 500 ppm+ folia application of ZnO and FeO nano particles performed best in Head diameter (cm), Marketable Head Yield/plot (kg), Marketable Head Yield/hectare (q/ha), Harvest Index (%) (18.68 cm, 3.15 kg, 212.86 qh, 90.65%).
Assessment of Genetic Parameters for Important Agronomic Traits in Sweet Potato (Ipomoea batatas (L.) Lam) Germplasm in Two Agro-ecological Regions of Nigeria
Authors: Agbim J. U. , Afuape S. O. , Ulasi J. I. , Keyagha E. R.
Published: July 2022

For an effective and efficient crop breeding program, collection of good genotypes that provides good agronomic background for the new variety to be developed must be available, and such genotypes must contain significant genetic variability for effective crop development. In order to determine the agronomic worth of a collection of sweetpotato genotypes so as to identify the superior ones under different agro-ecologies, and also to determine the extent of variability that exists among the genotypes, fifty-two genotypes were evaluated at Umudike (rainforest belt) and forty-eight at Otobi (humid guinea savannah) during the raining season using recommended protocols. While agronomic data were taken at 4 months after planting (MAP), sweetpotato virus disease (SPVD) incidence and severity scores were taken at 2 MAP. Results showed that significant (p<0.001) variation exists among the genotypes for all the traits except weight of unmarketable roots in both locations. Genotype PYT/12/074 had the highest root yield of 29.33 t/ha at the rainforest belt followed by Solo-2 and PYT/12/105 with yield levels of 27.67 and 26.33 t/ha, respectively. At Otobi, same PYT/12/074 had the highest root yield of 27.74 t/ha followed by Kwara and PYT/12/105 with yield levels of 27.67 and 26.33 t/ha, respectively. The principal component analysis identified marketable root weight, number of marketable roots, SPVD incidence and severity as the most important traits that influenced the observed variation among the genotypes. The biplot analysis further identified most of the orange-fleshed genotypes as highly susceptible to SPVD. Genetic studies of the traits showed that while broad-sense heritability estimates ranged from moderate to high for the important agronomic and SPVD traits, the high GCV and genetic advance observed portends a high genetic gain and good breeding progress in the breeding program using the genotypes.
Self-Regulated Learning Skills and English Proficiency
Authors: Bravo Venus Binghay
Published: July 2022

This descriptive-correlational study investigated the self-regulated learning skills (SRL) and English proficiency (EP) of 338 Grade 7 students from eight secondary schools within PAHASUKI districts. It specifically determined the demographic profile of the respondents and the levels of their self-regulated learning skills and proficiency in English. Significant differences on their SRL and EP levels with respect to gender, age and income as well as and the relationship between SRL and EP were likewise determined. A Likert scale and teacher-made multiple-choice test were used to gather data, which were analyzed using frequency, frequency percentage, mean standard deviation, ANOVA and Pearson r. Majority of the students were female, within the appropriate age for Grade 7, and had low family income. Their level of SRL was high which differed significantly with respect to gender but not significantly with respect to age and income. Students’ English proficiency in terms of listening and speaking skills were within developing level their skills in speaking and writing were in beginning level. Difference on English proficiency was significant with respect to income but not significant with respect to gender and age. The relationship between self-regulated learning skills and English proficiency was weak but positive and significant. Interventions were recommended based on the findings.
Leading a Community Engagement Approach for Integral Mission in Central Africa and Southeast Asia
Authors:   University of Madison- Wisconsin, Paltzer Jason
Published: July 2022

Community engagement is essential in global health mission organizations in order to effectively integrate physical and spiritual health. I experienced a progression in understanding faith-based community engagement in global health during my time as a health director in central Africa and Southeast Asia. The Facilitator phase of this progression leads to understanding the systems and networks as described by the Social-Ecological Model (SEM) and the Holistic Worldview Analysis (HWVA) model. Together, these can be used to guide church workers, faith-based public health practitioners, and development leaders in taking a holistic approach to improving community health and well-being in a way that learns from my experience and focuses on the Facilitator phase as the most effective. Integral mission understands that the physical and spiritual determinants of health are inseparable but is often challenged by diverse partnerships, community beliefs, and assumptions influencing cross-cultural health initiatives. Together, the SEM and HWVA models support a holistic community engagement strategy for integral mission to take place.
The Shared Reflective Practice of Co-Planning an Undergraduate Education Course between Online and Face-To-Face Teacher Educators
Authors:   Grand Canyon University, Sell Katy , Juarez Brandon ,   Grand Canyon University
Published: July 2022

The current paper presents a reflective account of two teacher educators, from different instructional modalities, co-planning an undergraduate face-to-face education course. Wenger’s writing around communities of practice provided the theoretical underpinning for the reflections put forward and contextual information regarding how the co-planning transpired. From a critical standpoint, observations and reflections related to the communication, challenges (and successes), and pedagogical decision-making between education colleagues are considered. Three central challenges are explored through the reflective lens: length of course between modalities, norming and autonomy, and scheduling between teacher educators to co-plan throughout the academic face-to-face semester. The qualitative nature of the study provides thick and rich detail pertaining to the shared reflections of the two teacher educators. The paper concludes with recommendations surrounding the continued exploration of how the instructional modality plays part in the co-planning process. Keywords: Teacher educators, modalities, higher education, co-planning, reflective practice
Analysis of Content and Phrasing of Health-Related Quality-of-Life Patient-Reported Outcome Measures Used in Patients With Acne
Authors: Yoon Jaewon , Homsi Haya A. , Barbieri John S.
Published: July 2022

This qualitative study examines patient-reported outcome measures used in the treatment of patients with acne.
Visceral Encounters: Unevenness in Moments of Foundational Apprehension
Authors: Young Jason
Published: July 2022

Dean of the College of Architecture and Design at the University of Tennessee, Jason Young looks at the work of one of the most prolific astronauts of drawn space, Michigan architectural academic Perry Kulper. Whether by hand or with the aid of computers, Kulper's drawings represent an odyssey of exploration, graphic verve and unafraid experimentation – bold, joyful and invested in a playful iconoclasm that is immediately endearing.
Making Rainbows: Landscapes for Negotiation
Authors: de Villiers Sarah
Published: July 2022

In recent years, Bartlett School of Architecture Professor CJ Lim has become interested in eco‐cities and social equity. His contemporary work, however, is not imbued with the lack of style and abundant hubris so often seen when architects attempt to tackle these bigger issues. His drawings still have the graphic vitality for which he has become internationally known. Johannesburg‐based Sarah de Villiers peruses and comments on his speculation for a ‘Rainbow Community’.
Hermeneutic Imagination: Drawing Out Freud
Authors: Pérez‐Gómez Alberto
Published: July 2022

Natalija Subotincic drinks from the well of Surrealism, in her case suffused with in‐depth drawing research into Sigmund Freud's consulting room and study and the precise placement of objects within them. This has led her to draw with objects in space as she constructs her own ‘museum’ cabinet of curiosities. Emeritus Professor of Architectural History and Theory Alberto Pérez‐Gómez takes us on a fascinating journey of discovery through her world.
Robust Piezoelectricity with Spontaneous Polarization in Monolayer Tellurene and Multilayer Tellurium Film at Room Temperature for Reliable Memory
Authors: Rao Gaofeng , Fang Hui , Zhou Ting , Zhao Chunlin , Shang Nianze , Huang Jianwen , Liu Yuqing , Du Xinchuan , Li Peng , Jian Xian , Ma Liang , Wang Jinlan , Liu Kaihui , Wu Jiagang , Wang Xianfu , Xiong Jie
Published: July 2022

Robust neuromorphic computing in the Big Data era calls for long‐term stable crossbar‐array memory cells; however, the elemental segregation in the switch unit and memory unit that inevitably occurs upon cycling breaks the compositional and structural stability, making the whole memory cell a failure. Searching for a novel material without segregation that can be used for both switch and memory units is the major concern to fabricate robust and reliable nonvolatile cross‐array memory cells. Tellurium (Te) is found recently to be the only peculiar material without segregation for switching, but the memory function has not been demonstrated yet. Herein, apparent piezoelectricity is experimentally confirmed with spontaneous polarization behaviors in elementary 2D Te, even in monolayer tellurene (0.4 nm), due to the highly oriented polarization of the molecular structure and the non‐centrosymmetric lattice structure. A large memory window of 7000, a low working voltage of 2 V, and high on switching current up to 36.6 µA µm−1 are achieved in the as‐fabricated Te‐based memory device, revealing the great promise of Te for both switching and memory units in one cell without segregation. The piezoelectric Te with spontaneous polarization provides a platform to build robust, reliable, and high‐density logic‐in‐memory chips in neuromorphic computing.
Defect Engineering for Efficient Cu2ZnSnS4 Solar Cells via Moisture‐Assisted Post‐Deposition Annealing
Authors: Sun Heng , Huang Jialiang , Young Trevor L. , Cong Jialin , Li Jianjun , Sun Kaiwen , Yan Chang , Soufiani Arman Mahboubi , Cui Xin , Nielsen Michael P. , Zhang Xueyun , Stride John A. , Green Martin A. , Hao Xiaojing
Published: July 2022

Sulfide kesterite Cu2ZnSnS4 (CZTS) solar cells, containing earth‐abundant and environmentally benign constituents, are regarded as promising candidates for thin‐film photovoltaic technologies. CZTS device performance, however, is currently limited by severe nonradiative recombination caused by abundant deep‐level defects. Herein, an effective defect engineering approach for high bandgap CZTS solar cells using a newly introduced moisture‐assisted post‐deposition annealing treatment is reported. This treatment modifies the local chemical composition within the heterojunction and CZTS grain boundaries and enhances the incorporation of Cd within the CZTS layer during CdS deposition. Cd not only accumulates at the grain boundaries, but it also presents in grain interiors where it occupies Cu lattice sites. The overall modification of the local chemical environment suppresses deep level defects and activates relatively shallow acceptor CuZn antisites and Cu vacancies, giving rise to remarkably improved device performance. This work opens a new direction for defect engineering of kesterite materials, which may also be applicable to other thin film semiconductors.
The impact of no‐till crop rotation on dryland soil properties and crop yields
Authors: Sainju Upendra M.
Published: July 2022

Information on the effect of no‐till crop rotation on a broad range of soil properties and long‐term crop yields is needed to evaluate its benefits on ecosystem services compared with monocropping. The objective of this study was to examine the effects of no‐till crop rotation (barley [Hordeum vulgare L.]/spring wheat [Triticum aestivum L.]–pea [Pisum sativum L.]) and monocropping [continuous barley/spring wheat] on 66 dryland soil physical, chemical, biological, and biochemical properties and long‐term crop yields at two dryland farm sites (14‐ and 36‐yr old) in the northern Great Plains. Soil samples collected to a depth of 15 cm in April 2019 were analyzed for soil properties and crop yields determined. At the long‐term site, crop rotation increased 11 properties, but reduced 16 of 66 soil properties compared with monocropping. At the short‐time site, crop rotation increased 6 properties, but reduced 13 of 66 soil properties compared with monocropping. Longer duration experiments showed more differences in soil properties due to crop rotation than shorter duration experiments. Spring wheat and barley yields were greater following pea than following spring wheat or barley during years with normal or above‐average precipitation at both sites. Pea yield in the crop rotation was also greater during these years. Barley/spring wheat–pea rotation can enhance some soil properties and dryland crop yields compared with continuous barley/spring wheat during wet years in the semiarid region of the northern Great Plains.
Usefulness of frailty to predict short‐ and long‐term outcomes in patients who have undergone major hepatectomy for perihilar cholangiocarcinoma
Authors: Hosoda Kiyotaka , Shimizu Akira , Kubota Koji , Notake Tsuyoshi , Masuo Hitoshi , Yoshizawa Takahiro , Sakai Hiroki , Hayashi Hikaru , Yasukawa Koya , Soejima Yuji
Published: July 2022

Aim

The influence of frailty on outcomes after hepatectomy for perihilar cholangiocarcinoma (PHCC) remains unclear. This study aimed to investigate the impact of frailty on the incidence of postoperative complications and survival after major hepatectomy for PHCC.

Methods

A total of 87 patients who had undergone surgery for PHCC between 2007 and 2020 were enrolled in this study. Frailty was scored retrospectively using the Clinical Frailty Scale (CFS). The survival and incidence of postoperative complications were compared based on the degree of frailty, and their risk factors were analyzed.

Results

The overall survival of the CFS score 1‐2 group was significantly higher than that of the CFS score 3‐7 group (P = .01). The survival benefit was especially observed in stage I or II PHCC. Furthermore, there were significant differences between the CFS score 1‐3 group and the CFS score 4‐7 group in the incidence of Clavien–Dindo classification grade ≥ IIIa (39.4% vs 70.6%; P = .03). Frailty was an independent risk factor for severe postoperative complications (odds ratio, 4.11; 95% confidence interval, 1.18‐15.20; P = .03) and the incidence of systemic complications (P < .01).

Conclusion

Frailty is a predictive factor for short‐ and long‐term outcomes in patients who have undergone major hepatectomy for PHCC.
Stable High‐Temperature Lithium‐Metal Batteries Enabled by Strong Multiple Ion–Dipole Interactions
Authors: Chen Tao , Jin Zhekai , Liu Yuncong , Zhang Xueqiang , Wu Haiping , Li Mengxue , Feng WenWen , Zhang Qiang , Wang Chao
Published: July 2022

Lithium‐metal batteries (LMBs) capable of operating stably at high temperature application scenarios are highly desirable. Conventional lithium‐ion batteries could only work stably under 60 °C because of the thermal instability of electrolyte at elevated temperature. Here we design and develop a thermal stable electrolyte based on stable solvation structure using multiple ion–dipole interactions. The strong coordination in solvated structure of electrolyte defines the Li deposition behaviour and the evolution of solid electrolyte interphase at high temperature, which is important to achieve high Li Coulombic efficiency and avoid Li dendritic growth. For high mass loading LiFePO4‐Li cells, the cells at 60 °C with conventional electrolyte easily run into failures, but the cells with our electrolyte at 90 °C and 100 °C could cycle more than 120 and 50 cycles respectively. This work provides new insight into electrolyte design and contributes to the development of high temperature LMBs.
Contribution of MicroRNA‐27b‐3p to Synovial Fibrotic Responses in Knee Osteoarthritis
Authors: Tavallaee Ghazaleh , Lively Starlee , Rockel Jason S. , Ali Shabana Amanda , Im Michelle , Sarda Clementine , Mitchell Greniqueca M. , Rossomacha Evgeny , Nakamura Sayaka , Potla Pratibha , Gabrial Sarah , Matelski John , Ratneswaran Anusha , Perry Kim , Hinz Boris , Gandhi Rajiv , Jurisica Igor , Kapoor Mohit
Published: July 2022

Objective

Synovial fibrosis contributes to osteoarthritis (OA) pathology, but the underlying mechanisms remain unknown. We have observed increased microRNA‐27b‐3p (miR‐27b‐3p) levels in synovial fluid of patients with late‐stage radiographic knee OA. Here, we investigated the contribution of miR‐27b‐3p to synovial fibrosis in patients with severe knee OA and in a mouse model of knee OA.

Methods

We stained synovium sections obtained from patients with radiographic knee OA scored according to the Kellgren/Lawrence scale and mice that underwent destabilization of the medial meniscus (DMM) for miR‐27b‐3p using in situ hybridization. We examined the effects of intraarticular injection of miR‐27b‐3p mimic into naive mouse knee joints and intraarticular injection of a miR‐27b‐3p inhibitor into mouse knee joints after DMM. We performed transfection with miR‐27b‐3p mimic and miR‐27b‐3p inhibitor in human OA fibroblast‐like synoviocytes (FLS) using reverse transcriptase–quantitative polymerase chain reaction (RT‐qPCR) array, RNA sequencing, RT‐qPCR, Western blotting, immunofluorescence, and migration assays.

Results

We observed increased miR‐27b‐3p expression in the synovium from patients with knee OA and in mice with DMM‐induced arthritis. Injection of the miR‐27b‐3p mimic in mouse knee joints induced a synovial fibrosis‐like phenotype, increased synovitis scores, and increased COL1A1 and α‐smooth muscle actin (α‐SMA) expression. In the mouse model of DMM‐induced arthritis, injection of the miR‐27b‐3p inhibitor decreased α‐SMA but did not change COL1A1 expression levels or synovitis scores. Transfection with the miR‐27b‐3p mimic in human OA FLS induced profibrotic responses, including increased migration and expression of key extracellular matrix (ECM) genes, but transfection with the miR‐27b‐3p inhibitor had the opposite effects. RNA sequencing identified a PPARG/ADAMTS8 signaling axis regulated by miR‐27b‐3p in OA FLS. Human OA FLS transfected with miR‐27b‐3p mimic and then treated with the PPARG agonist rosiglitazone or with ADAMTS8 small interfering RNA exhibited altered expression of select ECM genes.

Conclusion

Our findings demonstrate that miR‐27b‐3p has a key role in ECM regulation associated with synovial fibrosis during OA.
Antioxidant Thermogelling Formulation for Burn Wound Healing
Authors: Liu Minting , Chen Ying , Zhu Qiang , Tao Junjun , Tang Changming , Ruan Huajun , Wu Yunlong , Loh Xian Jun
Published: July 2022

Burns are the most common and devastating form of wounds and are usually accompanied by abnormal inflammation, inadequate extracellular matrix production, reduced angiogenesis, and lack of growth factor stimulation, which can significantly delay wound healing and lead to complications. Pearl powder, a traditional Chinese medicine, has been used to treat wound healing. In the present study, we found that supercritical CO2 extracted pearl peptides in the size range of “>10kd” have great potential to promote wound healing at the cellular level. Antioxidant hydrogels were designed using selenium‐containing block‐functionalized PEG/PPG polymers. Pearl peptide components were combined into polymeric materials to develop new promising wound dressings. It was shown that pearl peptide hydrogels increased skin fibroblast viability, enhanced cellular resistance to oxidative stress, enhanced tissue remodeling, promoted angiogenesis, and exhibited enhanced promotion in wound healing.
Comparison of coupon and pipe rack studies for selecting corrosion control treatment
Authors: Masters Sheldon V. , Poncelet‐Johnson Nicole , Walsh Ryan , Seidel Chad J. , Corwin Christopher J.
Published: July 2022

This study directly compared the data obtained from coupon studies and flow‐through pipe rack studies from two sources in the Denver Water system. The pipe rack study was completed over multiple years using harvested lead service lines. The coupon studies were completed in about 2 months using pure lead coupons. Orthophosphate at 2 mg/L was found to reduce lead concentrations by about 81% in the pipe racks, whereas 74%–81% was observed in the coupons. At an orthophosphate dose of 1 mg/L lead concentrations were reduced by 62%–65% in the pipe loop and by 55%–75% in the coupons, pH at 8.8 reduced lead by 45%–60% in the pipe racks and by 27%–48% in the coupons. The pipe racks were able to give insights into the transition from one condition to another, which is time‐based and dependent on existing pipe scales. Both types of demonstration studies produced similar conclusions about treatment options. The pipe rack was more representative of conditions in the distribution system while the coupon studies were performed in a fraction of the time.
The Clean Water Act Turns 50: A Critical Partner to the Safe Drinking Water Act
Authors: Tracy Mehan G.
Published: July 2022

Key Takeaways

In 1972, Congress overrode a presidential veto to pass the Clean Water Act in the interest of restoring the environmental integrity of US waters.

History reveals prevailing attitudes and concepts that did not consider a need for source water protection and human accountability.

One component of the Clean Water Act's continued progress in addressing current and emerging threats to source water quality is a strong relationship with the Safe Drinking Water Act.
Sulfurized Polypropylene as Low‐Cost Cathode Material for High‐Capacity Lithium‐Sulfur Batteries
Authors: Du Qian , Benedikter Mathis , Küster Kathrin , Acartürk Tolga , Starke Ulrich , Hoslauer Jean‐Louis , Schleid Thomas , Buchmeiser Michael R.
Published: July 2022

Among ‘beyond lithium ion’ energy storage, lithium sulfur (Li−S) batteries are one of the most promising technologies, as a result of the potential for high theoretical energy capacity at low cost. A key obstacle in exploiting the vast potential of Li−S batteries is the formation of soluble polysulfide species. Here, we report sulfurized polypropylene (S/PP‐500) synthesized in one‐step by reacting polypropylene (PP) with sulfur as a new polysulfide shuttle‐free cathode material for Li−S batteries. It exhibits a reversible capacity as high as 1000 mAh/gsulfur at 0.1 C and a sulfur loading of up to 68 wt%, which in turn allows for high sulfur loadings up to 47 % in the final cathode. The low‐cost starting materials together with the simple synthetic procedure and the good electrochemical performance in combination with a commercially available eslectrolyte make the S/PP‐500 a very promising cathode material for Li‐S batteries.
Combining network pharmacology with chromatographic fingerprinting and multicomponent quantitative analysis for the quality evaluation of Moutan Cortex
Authors: Wang Rui , Wang Xingchen , Xia Mengqiu , Yang Lanxiang , Cheng Wangkai , Song Qianqian
Published: July 2022

In this study, we combined network pharmacology, chromatographic fingerprinting and multicomponent quantitative analysis to evaluate the quality of Moutan Cortex (MC). Specifically, through network pharmacology, we obtained a comprehensive understanding of the active components and pharmacological activities of MC. In addition, the method of establishing fingerprint and multicomponent quantification by ultra high‐performance liquid chromatography is convenient and comprehensive, and can more fully reflect the overall distribution of various chemical components. Principal component analysis and discriminant least square analysis were used. The results show that MC plays a synergistic role through multiple targets and pathways. The contents of chemical components in MC from different sources were significantly different. Combining network pharmacology and multicomponent quantitative results, gallic acid, benzoyl paeonol, paeonol, methyl gallate, benzoic acid and paeonol can be used as quality markers for MC quality control. This study provides a comprehensive and reliable strategy for the quality evaluation of MC and determines its quality indicators to ensure the quality of Chinese herbal medicine.
TAVR in an XXXL annulus (1057 mm2) with type I bicuspid aortic valve
Authors: Russo Mark , Chen Chunguang , Sethi Ankur , Hakeem Abdul
Published: July 2022

We report the largest annulus (>1000 m2) treated with transcatheter aortic valve replacement to date. It highlights the unique challenges in planning, sizing, and deployment considerations in the setting of a very large and altered geometry of a bicuspid aortic valve.
Kinetics of Ammonium Thiosulfate Wet Air Oxidation under High‐Temperature Conditions
Authors: Wurm Julian , Pöschmann René , Thielert Holger , von Morstein Olaf , Repke Jens-Uwe
Published: July 2022

To remove H2S and HCN from acid gases, wet‐oxidative desulfurization such as the Takahax process can be applied. There, a continuous wastewater stream with high concentrations of ammonium thiosulfate and thiocyanate is discharged. By wet air oxidation of these salts at 473–573 K, fertilizer‐grade ammonium sulfate can be obtained. Thiosulfate wet air oxidation kinetics was investigated under industrially relevant conditions via the oxygen consumption rate in a high‐pressure reactor. Kinetic parameters were estimated with a dynamic reactor model. The experimental data was reproduced with a good average deviation of 2.17 %, and the applied reaction pathway is simple due to the high temperatures. This is an important step towards taylor‐made reactors for wet air oxidation of Takahax wastewater.
High‐Throughput Assessments for Storage Stability, In Vitro Release, and Particle Size of Encapsulated Biocontrol Fungi in Hydrogel Beads
Authors: Santos‐Díaz Adriana , Uribe‐Gutiérrez Liz , Cruz‐Barrera Mauricio
Published: July 2022

Use of biocontrol fungi (BF) such as Trichoderma spp. minimizes fungicide input and increases both plant nutrition and protection from disease. Thus, the introduction of BF by novel inoculants in crop management is an excellent strategy to promote sustainable antagonism activity. Within these strategies, encapsulation in polymeric matrices such as hydrogel beads will play a prominent role in providing an effective carrier/protector and long‐lasting bioproduct. These studies have used biomaterials with tunable physicochemical features, providing differential morphologies, compaction, and disintegration, among other parameters. Aiming at developing bioproducts within polymeric hydrogel beads, viability of encapsulated conidia, storage stability, release of active ingredient, and particle size are essential. However, there are no reports that detail standardized and comprehensive methods to evaluate the characterization of these bioproducts. We describe step‐by‐step protocols that go from sample preparation to testing the viability and storage stability using vacuum‐sealed aluminum foil bags. We also describe a high‐throughput in vitro method for quantifying released fungal conidia of BF at different pH values. Finally, the particle size of beads is established by bright‐field microscopy. These protocols could be transferable to other biological actives, accessible to researchers in the microbiology and bioengineering communities. © 2022 Wiley Periodicals LLC.

Basic Protocol 1: Viability of encapsulated conidia

Basic Protocol 2: Study of stability of prototypes under storage

Basic Protocol 3: Release profile of encapsulated conidia at different pH conditions

Basic Protocol 4: Determination of capsule size
Core needle biopsy for the diagnosis of primary soft tissue lesions: Accuracy and diagnostic challenges
Authors: Layfield Lester J. , Stegelmeier Paul , Wang Liangli , Esebua Magda
Published: July 2022

Background

Core needle biopsy (CNB) and fine needle aspiration (FNA) are currently the most common biopsy methods for investigation of soft tissue lesions. Selection of the method to be used depends on a number of factors including diagnostic accuracy, local expertise with the techniques and the need for ancillary testing. We investigated the diagnostic accuracy of CNB and factors influencing the selection of CNB or FNA.

Methods

An electronic search of the surgical pathology records for all core needle biopsies of soft tissue lesions with subsequent incisional biopsies or excisions between January 1, 2015 and December 31, 2021 was performed. Searches of the literature for publications documenting diagnostic accuracy of core biopsy and FNA were performed using the Pub Med literature data base.

Results

The electronic search yielded 177 CNBs with appropriate follow‐up. Six cases were non‐diagnostic. The remaining 171 cases showed an accuracy of 90% for separation of benign from malignant with two false‐positive and 17 false‐negative diagnoses. The literature search revealed 11 series of CNBs with a diagnostic accuracy of 74% to 97%. The literature search revealed 20 series of FNAs with an accuracy of 84.8% to 100% for separation of benign from malignant.

Conclusions

Core needle biopsy is a highly accurate diagnostic technique with an accuracy of 90% for separation of benign from malignant lesions. The percentage of non‐diagnostic cases is low (3.4%). No significant biopsy related complications were seen in this study.
Increase in protandry over time in a long‐distance migratory bird
Authors: Hedlund Johanna , Fransson Thord , Kullberg Cecilia , Persson Jan‐Olov , Jakobsson Sven
Published: July 2022

Protandry is a widespread life‐history phenomenon describing how males precede females at the site or state of reproduction. In migratory birds, protandry has an important influence on individual fitness, the migratory syndrome, and phenological response to climate change. Despite its significance, accurate analyses on the dynamics of protandry using data sets collected at the breeding site, are lacking. Basing our study on records collected during two time periods, 1979 to 1988 and 2006 to 2016, we aim to investigate protandry dynamics over 38 years in a breeding population of willow warblers (Phylloscopus trochilus). Change in the timing of arrival was analyzed in males and females, and protandry (number of days between male and female arrival) was investigated both at population level and within breeding pairs. Our results show advancement in the arrival time at the breeding site in both sexes, but male arrival has advanced to a greater extent, leading to an increase in protandry both at the population level and within breeding pairs. We did not observe any change in sex ratio that could explain the protandry increase, but pronounced temperature change has occurred and been reported in the breeding area and along the migratory route. Typically, natural selection opposes too early arrival in males, but given warmer springs, this counteracting force may be relaxing, enabling an increase in protandry. We discuss whether our results suggest that climate change has induced sex‐specific effects, if these could be evolutionary and whether the timing of important life‐history stages such as arrival at the breeding site may change at different rates in males and females following environmental shifts.
Performance Evaluation of Novel Heat Pipe‐Assisted Thermal Storage System with Parabolic Trough Solar Collector Using Nanofluid
Authors: Kalbande Vednath P. , Walke Pramod V. , Untawale Sachin , Mohan Man
Published: July 2022

The experimentation has been performed in Central Indian climatic conditions to investigate the performance of the novel heat‐pipe‐assisted thermal storage system with parabolic trough solar collector and nanofluid. The present thermal energy storage system is nanofluid (Al2O3/soybean oil) based and the eutectic mixture of KNO3 and NaNO3 (nitrate salt) in the molar ratio of 40:60 has been used as phase change material to store the heat energy. The system is based on the natural circulation of heat transfer fluid (thermo‐syphon) and the receiver to arrest the solar radiation is parabolic trough solar collector using an evacuated tube. The major and novel incorporation in this system is the heat pipe insertion in the storage unit of the system, which provides better heat transfer, and hence the improved storage capacity is achieved. The final remark of this study has been done with the comparison of the present system with the existing and similar kinds of thermal energy storage systems. For the same charging cycle time and same climatic conditions, the compared value of specific heat storage capacity is 67% higher as compared to the average value of other considered systems.
Nonthermal Plasma Treatment for Electrocatalysts Structural and Surface Engineering
Authors: Tang Jiayi , Su Chao , Shao Zongping
Published: July 2022

Structure and surface modification of electrocatalysts demonstrates a promising lead for achieving excellent electrocatalytic activity and efficiency. Among various surface modification strategies, nonthermal plasma technique possesses an irreplaceable role due to the merits of simple but controllable operation procedure, low pollution, low cost, and easy scale‐up for practical applications. Nonthermal plasma treatment, as a powerful tool for material surface and structural engineering, can mainly benefit the electrocatalytic reactions in the following aspects: surface atom doping or reconstructing, introducing vacancies or defects, surface partially reducing or oxidizing, and increasing the porosity or roughness. Given to its flexibility, plasma modification is gaining a noticeable popularity, and great progress has been made in applying plasma for optimizing surface properties of the mainstream electrocatalysts, including metal‐free carbon materials, metal oxides, and other compounds, as well as organometallic electrocatalysts, etc. This review first summarizes the recent advances in nonthermal plasma modification for achieving desirable electrocatalytic behaviors, aiming to highlight the cutting‐edge function designs of electrocatalysts with plasma technology. It is hoped that this work can give some inspiration for the development of highly efficient electrocatalysts.
Ionic Liquid Gating in Perovskite Solar Cells with Fullerene/Carbon Nanotube Collectors
Authors: Mahmoodpoor Abolfazl , Verkhogliadov Grigorii , Melnikov Roman , Saranin Danila S. , Voroshilov Pavel M. , Sapori Daniel , Haroldson Ross , Nasibulin Albert G. , Ishteev Arthur R. , Ulyantsev Vladimir , Makarov Sergey V. , Zakhidov Anvar A.
Published: July 2022

Metallic cathodes are one of reasons for instability in perovskite solar cells due to reaction with halogens I−, Br−, and it is desirable to have stable carbon‐based cathodes, particularly carbon nanotubes (CNTs), and transport layers such as C60/C70. In this work, we show that gating of such top CNT cathode in ionic liquid by changing gate voltage (V
g) tunes the Fermi level of CNT by electrical double layer charging and causes lowering of the barrier at C60/C70 electron transport layer (ETL). Moreover, at higher V
g the ions further propagate into fullerene ETL by electrochemical n‐doping, which increases dramatically performance by further raising mostly two parameters: short‐circuit current and fill factor, resulting in solar cell efficiency growth from 3% to 11%. Surprisingly, open‐circuit voltage (V
oc) is not sensitive to V
g in the perovskite solar cells, on the contrary to strongly enhanced V
oc in ionically gated organic solar cells, where it is the main effect for ionic gating. This insensitivity of V
oc to lowering of the work function of CNT electrode is a clear indication that V
oc in the perovskite solar cell is determined by inner p‐i‐n junction formation in the perovskite layer itself.
Towards identifying a method of screening for autism amongst women with restrictive eating disorders
Authors: Adamson James , Brede Janina , Babb Charli , Serpell Lucy , Jones Catherine R. G. , Fox John , Mandy Will
Published: July 2022

Objective

Up to 37% of patients with anorexia nervosa score above cut‐off on autism screening measures. These individuals typically have poorer outcomes from standard eating disorder interventions and could therefore benefit from adaptations. Accurately identifying these individuals is important for improving autism referral processes and clinical pathway decisions. This study's aim was to identify subscales of questionnaires measuring constructs associated with either autism or eating disorders that, when combined with traditional autism screening measures, would improve the ability to identify women with restrictive eating disorders who might benefit from a full autism assessment.

Method

One hundred and sixty women with restrictive eating disorders, with (n = 42) or without (n = 118) an autism diagnosis completed a battery of questionnaires. Using conditional stepwise binary logistic regression, we attempted to improve the autism spectrum quotient 10 item's (AQ‐10) ability to discriminate between autistic and non‐autistic women in a restrictive eating disorder sample.

Results

In a binary logistic regression model, the AQ‐10 reliably discriminated between autistic and non‐autistic women with an accuracy rate of 85% but had relatively low (69%) sensitivity, reflecting a high rate of false negatives. Adding three subscales to the model (Glasgow Sensory Questionnaire Auditory, Camouflaging Autistic Traits Questionnaire Compensation and Toronto Alexithymia Scale Externally Orientated Thinking) significantly improved its differentiating ability (accuracy = 88%, sensitivity = 76%, specificity = 92%).

Conclusions

We have identified three subscales that, when used in combination with the AQ‐10, may help clinicians understand the pattern of autistic traits in their patients with a restrictive eating disorder. This can inform clinical decisions about whether to refer for a full autism assessment and whether to adapt standard eating disorder treatments to accommodate autistic traits. Future studies are needed to test the model in samples where participants have undergone a full autism assessment.