bluuebunny/crossref_metadata_2025 huggingface dataset:
Bone and cartilage differentiation of a single stem cell population driven by material interface
Authors: Donnelly Hannah , Smith Carol-Anne , Sweeten Paula E , Gadegaard Nikolaj , Meek RM Dominic , D’Este Matteo , Mata Alvaro , Eglin David , Dalby Matthew J
Published: May 2017

Adult stem cells, such as mesenchymal stem cells, are a multipotent cell source able to differentiate towards multiple cell types. While used widely in tissue engineering and biomaterials research, they present inherent donor variability and functionalities. In addition, their potential to form multiple tissues is rarely exploited. Here, we combine an osteogenic nanotopography and a chondrogenic hyaluronan hydrogel with the hypothesis that we can make a complex tissue from a single multipotent cell source with the exemplar of creating a three-dimensional bone–cartilage boundary environment. Marrow stromal cells were seeded onto the topographical surface and the temperature gelling hydrogel laid on top. Cells that remained on the nanotopography spread and formed osteoblast-like cells, while those that were seeded into or migrated into the gel remained rounded and expressed chondrogenic markers. This novel, simple interfacial environment provides a platform for anisotropic differentiation of cells from a single source, which could ultimately be exploited to sort osteogenic and chondrogenic progenitor cells from a marrow stromal cell population and to develop a tissue engineered interface.
The Environmental Services Perspective on Hospital Room Design: A Mixed-Methods Approach
Authors: Patterson Emily S. , Sanders Elizabeth , Sommerich Carolyn M. , Evans Kevin D. , Lavender Steven A. , Li Jing
Published: May 2017

Our aim is to enhance the safety and efficiency of all healthcare staff by designing patient rooms that meet the physical and cognitive needs of those providing direct and indirect patient care in hospital settings. A mixed-methods study was employed, where findings were compiled from twenty-six environmental services personnel across study activities. The insights were grouped into six categories of challenges with the design of hospital rooms in acute care settings: room cleaning, bathroom, room size, furniture, communication, and a miscellaneous ‘other’ category. There are design implications for storage, room design features, locations of room items, and fabrics and finishes.
Purchasing for Safety: A Human Factors-Influenced Procedure for Evaluating Medical Products
Authors: Fuller Helen J. A. , Lightner Nancy J. , Maddox Kyle D. , Shanawani Hasan , Bagian Tandi , Hemphill Robin
Published: May 2017

Safety reports related to products and devices used in health care have demonstrated that not all items can be considered equal in terms of usability, compatibility, and functionality, which can result in patient safety concerns. Hospital systems use a wide variety of products when providing care to patients. This variability may contribute to purchasers failing to fully understand and define the needs for these products. In addition, it is necessary to define what a high-quality product is, including what minimal technical requirements it must meet. The Veteran’s Health Administration (VHA) is the largest health care system in the United States; as such, it possesses the ability to learn from a large group of health care providers as well as a great deal of purchasing power. Purchasing for Safety is a procedure for investigating medical devices or products with an end goal of improving the purchasing decision. Purchasing for Safety can help hospitals and health care systems to systematically evaluate medical products and devices for issues that may lead to patient safety concerns. By conducting careful testing and documenting methods and findings, the test team can assist stakeholders in making purchasing decisions that may ultimately result in better patient care. The greater formality introduced in Purchasing for Safety will help hospitals justify purchasing decisions, and the thoroughness of the investigation will promote patient safety.
Clustering and Prioritizing Patient Safety Issues during EHR Implementation and Upgrades in Hospital Settings
Authors: Patterson Emily S. , Anders Shilo , Moffatt-Bruce Susan
Published: May 2017

Our aim was to elicit, label, and prioritize clusters of de-identified patient safety issues experienced during the implementation and upgrade installations of Electronic Health Records (EHRs) in hospitals. Conference participants included clinical personnel (physicians, nurses, pharmacists), human factors experts, patient safety experts, information technology experts from vendors and hospitals, academic experts, graduate students, and other attendees. De-identified reports of patient safety issues were shared via share4safety@gmail.com by conference and non-conference attendees before and during a 90-minute session featured at the Human Factors in Healthcare International Symposium on March 8, 2017. One submitted example of a reported patient safety issue was provided to the group. During the session, each attendee shared with a partner five concerns and identified their top concern. Subsequently, each two-person group shared with the larger group these issues, which were written by a facilitator onto sticky paper and placed on the walls. The issues were grouped using pre-defined categories and new categories were identified. Next, each participant voted for the highest priority cluster and/or individual patient safety issue using stickers. This paper reports the results of the interactive session, including the labeled and prioritized clusters and illustrative examples for each cluster. These clusters may inform reporting systems and quality improvement initiatives with health information technology where choices made during implementation and upgrades as well as design flaws with EHR technology both contribute and interact to produce potential patient safety issues.
Who is Drinking Our Kool-Aid? Hear Clinicians’ Perspective of their Human Factors Practitioner
Authors: Khunlertkit Adjhaporn (Nana) , Rivera A. Joy , Yin Shanqing , Wolf Laurie , Karavite Dean , Dulude Catherine , Regli Susan Harkness
Published: May 2017

Human factors (HF) has multiple domains that integrate various disciplines; and its principles and methods can be diversely applied within an organization. Healthcare organizations have started to deploy HF Practitioner (HFP) to assist in enhancing patient safety. However, the path for HFP integration into a hospital is still immature, clinical staff may be unclear of how to effectively collaborate with their HFP, and what benefits could HFP provide. This panel brings in 5 panelists from different organizations, who will share their experience in collaborating with their clinical advocate. Most importantly, audiences will hear their clinician advocates’ perceptions of the collaborations and benefits that their HFP has delivered, which encouraged them to drink our HFP ‘Kool-Aid.’
Higher serum 25(OH)D concentrations are associated with improved FEV1and FVC in adolescence
Authors: Flexeder Claudia , Thiering Elisabeth , Koletzko Sibylle , Berdel Dietrich , Lehmann Irina , von Berg Andrea , Hoffmann Barbara , Bauer Carl-Peter , Heinrich Joachim , Schulz Holger
Published: May 2017

Vitamin D plays a role in the development of the immune system and the lung, as well as in airway remodelling. Therefore, this study investigated the association between serum 25-hydroxyvitamin D (25(OH)D) concentrations and spirometric lung function parameters at age 15 years.

In the German birth cohorts GINIplus and LISAplus, lung function testing by spirometry and 25(OH)D measurements were performed during the 15-year follow-up examinations. Valid lung function measurements pre- and/or post-bronchodilation and serum 25(OH)D concentrations, which were adjusted for the date of blood sampling to account for seasonal variability, were available for 2607 adolescents. Associations between 25(OH)D concentrations and spirometric parameters were analysed using generalised additive models adjusted for confounding factors.

Serum 25(OH)D concentrations were significantly associated with forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1) and FEV1/FVC measured before bronchodilation after adjustment for potential confounders: FEV1increased by 10 mL (95% CI 2–17), FVC by 20 mL (95% CI 12–28) and FEV1/FVC decreased by 0.177% (95% CI −0.286 to −0.067) per 10 nmol·L−1increase in 25(OH)D concentrations. Flow rates (forced expiratory flow rates at 25, 50 and 75% of exhaled FVC (FEF25, FEF50, FEF75) and mean flow rate between 25 and 75% of FVC (FEF25–75)) were not associated with vitamin D. Similar associations were observed for lung function parameters measured after bronchodilation.

Vitamin D concentrations are positively associated with volume-related lung function parameters pre- and post-bronchodilation, suggesting structural changes in peripheral airways.
Burden of non-tuberculous mycobacterial pulmonary disease in Germany
Authors: Diel Roland , Jacob Josephine , Lampenius Niklas , Loebinger Michael , Nienhaus Albert , Rabe Klaus F. , Ringshausen Felix C.
Published: May 2017

The objective of this study was to estimate the burden of disease in incident patients with non-tuberculous mycobacterial pulmonary disease (NTM-PD).

A sample of 7 073 357 anonymised persons covered by German public statutory health insurances was used to identify patients with NTM-PD. In total, 125 patients with newly diagnosed NTM-PD in 2010 and 2011 were matched with 1250 control patients by age, sex and Charlson Comorbidity Index, and followed for 39 months.

The incidence rate for NTM-PD was 2.6 per 100 000 insured persons (95% CI 2.2–3.1). The mortality rate for patients with NTM-PD and the control group in the observational period was 22.4% and 6%, respectively (p<0.001). Mean direct expenditure per NTM-PD patient was €39 559.60 (95% CI 26 916.49–52 202.71), nearly 4-fold (3.95, 95% CI 3.73–4.19) that for a matched control (€10 006.71, 95% CI 8907.24–11 106.17). Hospitalisations were three times higher in the NTM-PD group and accounted for 63% of the total costs. Attributable annual direct costs and indirect work-loss costs in NTM-PD patients were €9093.20 and €1221.05 per control patient, respectively. Only 74% of NTM-PD patients received antibiotics and nearly 12% were prescribed macrolide monotherapy.

Although NTM-PD is considered rare, the attributable mortality and financial burden in Germany are high. Efforts to heighten awareness of appropriate therapy are urgently needed.
Broadband seismic over/under sources and their designature-deghosting
Authors: Amundsen Lasse , Pedersen Ørjan , Osen Are , Robertsson Johan O. A. , Landrø Martin
Published: May 2017

The source depth influences the frequency band of seismic data. Due to the source ghost effect, it is advantageous to deploy sources deep to enhance the low-frequency content of seismic data. But, for a given source volume, the bubble period decreases with the source depth, thereby degrading the low-frequency content. At the same time, deep sources reduce the seismic bandwidth. Deploying sources at shallower depths has the opposite effects. A shallow source provides improved high-frequency content at the cost of degraded low-frequency content due to the ghosting effect, whereas the bubble period increases with a lesser source depth, thereby slightly improving the low-frequency content. A solution to the challenge of extending the bandwidth on the low- and high-frequency side is to deploy over/under sources, in which sources are towed at two depths. We have developed a mathematical ghost model for over/under point sources fired in sequential and simultaneous modes, and we have found an inverse model, which on common receiver gathers can jointly perform designature and deghosting of the over/under source measurements. We relate the model for simultaneous mode shooting to recent work on general multidepth level array sources, with previous known solutions. Two numerical examples related to over/under sequential shooting develop the main principles and the viability of the method.
Ukraine and the Middle East
Authors: Bishku Michael B.
Published: May 2017

Ukraine is a country with close ethnic and historical ties to Russia, although it seeks to limit the political and economic influence of its more powerful neighbor. Therefore, since independence Ukraine has attempted to diversify its international relations as much as possible and to seek support for its territorial integrity. In the long run, it regards its political and economic futures as connected with the West. Meanwhile, the Middle East offers an alternative to mitigate pressure from Russia and to develop mutually beneficial relations with Turkey and Israel, with whom there are strong historical and cultural connections that offer some promise.
The Syrian Kurds and the Democratic Union Party: The Outsider in the Syrian War
Authors: Plakoudas Spyridon
Published: May 2017

By June 2016, the Kurds of Syria (just 12 percent of the country's total population) controlled almost all of the 822-kilometer Turkish-Syrian border and advanced against Manbij and Raqqa — the Islamic State's resupply center and capital, respectively. How did the Syrian Kurds grow from pariahs to kingmakers in northern Syria? This essay surveys the strategy of the Democratic Union Party (PYD), the most powerful organization among the Syrian Kurds, from 2011 until the first half of 2016, and shows how the PYD's realpolitik secured the party's survival and, eventually, success in the midst of a vicious sectarian civil war.
Muslim Responses to the Crusades: A Brief Survey of Selected Literature
Authors: Gada Muhammad Yaseen
Published: May 2017

There is a wealth of literature on the Western perspective of the Crusades. The subject has crossed academic disciplines because of the availability of the literature in the modern world. That does not necessarily mean that what has been said about the Crusades is completely correct. Moreover, little attention is given to the side against which the Crusades were launched in the Middle Ages, and not much has been written on the Muslim responses to the Crusades. The recent past, however, has produced some interesting research on the medieval Muslim perspective and understanding of the Crusades and Crusaders, as seen and recorded by the Muslim scholars of that period. This essay explores and surveys the existing literature on the Muslim responses to the Crusades.
Parallel in vivo monitoring of pH in gill capillaries and muscles of fishes using microencapsulated biomarkers
Authors: Borvinskaya Ekaterina , Gurkov Anton , Shchapova Ekaterina , Baduev Boris , Shatilina Zhanna , Sadovoy Anton , Meglinski Igor , Timofeyev Maxim
Published: May 2017

Tracking physiological parameters in different organs within the same organism simultaneously and in real time can provide an outstanding representation of the organism's physiological status. The state-of-the-art technique of using encapsulated fluorescent molecular probes (microencapsulated biomarkers) is a unique tool that can serve as a platform for the development of new methods to obtain in vivo physiological measurements and is applicable to a broad range of organisms. Here, we describe a novel technique to monitor the pH of blood inside the gill capillaries and interstitial fluid of muscles by using microencapsulated biomarkers in a zebrafish model. The functionality of the proposed technique is shown by the identification of acidification under anesthesia-induced coma and after death. The pH in muscles reacts to hypoxia faster than that in the gill bloodstream, which makes both parameters applicable as markers of either local or bodily reactions.
Oxygen- and Sulfur-Bridged Bianthracene V-Shaped Organic Semiconductors
Authors: Mitsui Chikahiko , Yamagishi Masakazu , Shikata Ryoji , Ishii Hiroyuki , Matsushita Takeshi , Nakahara Katsumasa , Yano Masafumi , Sato Hiroyasu , Yamano Akihito , Takeya Jun , Okamoto Toshihiro
Published: May 2017

A series of oxygen- and sulfur-bridged bianthracene V-shaped π-electronic cores are facilely synthesized. We clarify their fundamental properties and aggregated structures in single crystals as well as measure their transistor performances in single crystal field-effect transistors. Both V-shaped molecules possess bent structures induced by the intermolecular interaction in a herringbone-packing manner. A theoretical calculation study reveals that the driving force of the bent structures originates from the strong dispersion energy. Additionally, the bent conformation plays a crucial role in the formation of a dense packing structure, resulting in an attractive intermolecular overlap. An examination of the charge transport indicates that the hole mobility is up to 2.0 cm2/Vs. Finally, to understand the anisotropies of the mobility in single crystals, the transistors are evaluated when the channel direction is either parallel or orthogonal to the column direction in the herringbone packing along with their band structure calculations. Sulfur-bridged V-shaped π-electronic cores are more suitable for two-dimensional carrier-transport than oxygen-bridged analogs.
Which Entrepreneurs are Coachable and Why?
Authors: Bryan Kevin A. , Tilcsik András , Zhu Brooklynn
Published: May 2017

Is coachability a usable concept for startups? Using a dataset on high-growth startups in a prominent university incubator, we show that firm characteristics do predict which firms are likely to follow advice but that these “coachable” firms are not more likely to achieve positive outcomes. The reason is that advice may be rejected either because the firm is stubborn and uncoachable, or because the firm possesses capabilities related to the advice which is hard for outsiders to observe.
Endogenous Appropriability
Authors: Gans Joshua S. , Stern Scott
Published: May 2017

Most approaches to entrepreneurship assume that entrepreneurial control over their inventions is critical for success and, in turn, for incentives. Such control is usually supported by regulations that protect intellectual property including patents, copyrights, and trade secrets. Each give the entrepreneurs control over who can appropriate value from their activities. However, we note that another, distinct path exists for appropriation by entrepreneurs' execution. Execution forgoes the formal protection from control instead of a more rapid approach to market in the pursuit of capabilities that will allow entrepreneurs to compete with others in the future rather than block their activities per se. We characterize the conditions under which one path is preferred to another and present evidence from university startups delineating the tradeoffs at the heart of our theoretical approach.
Trade and Manufacturing Jobs in Germany
Authors: Dauth Wolfgang , Findeisen Sebastian , Suedekum Jens
Published: May 2017

The German economy exhibits rising service and declining manufacturing employment, but this decline is much sharper in import-competing than export-oriented branches. We first document the individual-level job transitions behind those trends. They are not driven by manufacturing workers who smoothly switch to services. The observed shifts are entirely due to young entrants and returnees from non-employment. We then investigate if rising trade with China and Eastern Europe causally affected those labor flows. Exploiting variation across industries and regions, we find that globalization did not speed up the manufacturing decline in Germany. It even retained those jobs in the economy.
A Context-Robust Measure of the Disincentive Cost of Unemployment Insurance
Authors: Schmieder Johannes F. , von Wachter Till
Published: May 2017

This paper proposes a new measure of the disincentive cost of unemployment insurance (UI): the ratio of the behavioral cost (BC) to the mechanical cost (MC) of a UI reform. This measure represents the labor supply distortion relative to the additional (mechanical) transfer from the UI reform. We show the BC/MC ratio naturally arises from a model of optimal UI and can be readily computed and compared across different types of reforms and labor market contexts. We summarize the evidence regarding the BC/MC ratio for existing studies and relate it to typical measures of employment effects of UI.
Redesigning the Israeli Psychology Master's Match
Authors: Hassidim Avinatan , Romm Assaf , Shorrer Ran I.
Published: May 2017

We report on the centralization of a two-sided matching-with-contracts market, in which pre-existing choice functions violate the substitutes condition. The ability to accommodate these choice functions was critical for the success of our design. The new mechanism is stable and strategy-proof for applicants. It is well accepted by both sides of the market. Our study provides a strong empirical validation for the practical relevance of recent theoretical advances on matching without substitutes.
Assortative Matching under Asymmetric Information: Evidence from Malawi
Authors: Angelucci Manuela , Bennett Daniel
Published: May 2017

Asymmetric information is a key feature of the marriage market. In HIV-endemic settings, HIV risk is an important partner attribute that may influence marriage timing and partner selection. We use a sample of married women in rural Malawi to validate a model of positive assortative matching under asymmetric information. Several correlations support this framework, suggesting that HIV risk contributes to adverse selection in the marriage market in this setting.
Tying the Double-Knot: The Role of Assets in Marriage Commitment
Authors: Lafortune Jeanne , Low Corinne
Published: May 2017

What explains the growing gap in marriage rates between socioeconomic groups? We present a robust stylized fact not previously documented: marriage rates are higher for individuals with more assets. We argue this may be driven by marriage and cohabitation becoming increasingly similar in a number of ways except for the way assets become marital property to be divided upon divorce in marriage while they remain individual property in the case of cohabitation. We propose that ownership of assets may provide “insurance” to the partner making individually costly, but jointly optimal, investments in children, thus raising the value of marriage.
Cross-Country Evidence on the Relationship between Overwork and Skilled Women's Job Choices
Authors: Cortes Patricia , Pan Jessica
Published: May 2017

This paper examines the relationship between the prevalence of overwork and skilled women's labor force participation and occupational choice. Using country-level variation, we find a negative relationship between the share of males working 50+ hours a week and the LFP of young married women, with the correlation being much smaller for single women and older married women. Using a panel of occupations across countries, we find that overwork in an occupation is negatively correlated with the share of married women working in that occupation. This finding is robust to controlling for the occupational distribution of groups with fewer household responsibilities.
The Econometrics and Some Properties of Separable Matching Models
Authors: Galichon Alfred , Salanié Bernard
Published: May 2017

We present a class of one-to-one matching models with perfectly transferable utility. We discuss identification and inference in these separable models, and we show how their comparative statics are readily analyzed.
Does Forest Loss Increase Human Disease? Evidence from Nigeria
Authors: Berazneva Julia , Byker Tanya S.
Published: May 2017

We examine the impact of forest loss on three infectious diseases attributed to modifiable environmental factors in the last decade in Nigeria. Geolinking a new high-resolution dataset of global forest change to child-level health data from the Nigeria Demographic and Health Surveys from 2008 and 2013, we find that forest loss significantly increases the incidence of malaria, though it does not affect the incidence of diarrhea and respiratory diseases. The impact of forest loss on malaria is large and the dynamic pattern of the impact suggests a temporary ecological disturbance consistent with findings in the tropical medicine literature.
Shale Gas Development and Drinking Water Quality
Authors: Hill Elaine , Ma Lala
Published: May 2017

Recent studies have linked shale gas development (SGD) to ground water contamination. The extent of these environmental externalities, to date, remains uncertain. To address this gap, we examine whether shale gas development systematically affects drinking water quality by creating a novel dataset that relates SGD to public drinking water samples in Pennsylvania. Our difference-in-differences strategy finds evidence that additional well pads drilled within 1 kilometer of a community water system intake increases shale gas-related contaminants in drinking water. These results are striking considering that our data are based on water sampling measurements taken after municipal treatment.
Excess Male Infant Mortality: The Gene-Institution Interactions
Authors: Pongou Roland , Kuate Defo Barthelemy , Tsala Dimbuene Zacharie
Published: May 2017

Excess male mortality at early ages is an important source of child inequality in most societies. We examine how improvement in the quality of political institutions affects the male survival disadvantage. Using data on twins in combination with a natural experiment on the development of African institutions, we quantify the distinct effects of biology and preconception environment on the infant mortality sex gap and find that these effects are important only in poor institutions. The analysis implies that improved institutions constrain genetic expression and mitigate preconception influences on excess male infant mortality, which is an optimistic finding with pragmatic implications.
Patient waiting time in the outpatient clinic at a central surgical hospital of Vietnam: Implications for resource allocation
Authors: Tran Tho Dinh , Nguyen Uy Van , Minh Nong Vuong , Tran Bach Xuan
Published: May 2017

Background: Patient waiting time is considered as a crucial parameter in the assessment of healthcare quality and patients’ satisfaction towards healthcare services. Data concerning this has remained limited in Vietnam. Thus, this study aims to assess patient waiting time in the outpatient clinic in Viet Duc Hospital (Hanoi, Vietnam) in order to enable stakeholders to inform evidence-based interventions to improve the quality of healthcare services.

Methods: A cross-sectional study was conducted from June 2014 to June 2015 in the outpatient clinic at Viet Duc Hospital. Waiting time stratified by years (2014 and 2015), months of the year, weekdays, and hours of the day were extracted from Hospital Management software and carefully calculated. Stata 12.0 was employed to analyze data, including the average time (M± SD), frequencies and percentage (%).

Results: There was a total of 137,881 patients involved in the study. The average waiting time from registration to preliminary diagnosis in 2014 was 50.41 minutes, and in 2015 was 42.05 minutes. A longer waiting time was recorded in the morning and in those having health insurance.

Conclusions: Our study highlights the essential need for human resource promotion to reduce patient waiting time. Also, attention should be paid to the simplification of administrative procedures in order to reduce waiting time among insured patients.
Electrocortical correlations between pairs of isolated people: A reanalysis
Authors: Radin Dean
Published: May 2017

A previously reported experiment collected electrocortical data recorded simultaneously in pairs of people separated by distance. Reanalysis of those data confirmed the presence of a time-synchronous, statistically significant correlation in brain electrical activity of these distant “sender-receiver” pairs. Given the sensory shielding employed in the original experiment to avoid mundane explanations for such a correlation, this outcome is suggestive of an anomalous intersubjective connection.
Transcriptomic analysis of Saccharomyces cerevisiae x Saccharomyces kudriavzevii hybrids during low temperature winemaking
Authors: Tronchoni Jordi , García-Ríos Estéfani , Guillamón Jose Manuel , Querol Amparo , Pérez-Torrado Roberto
Published: May 2017

Background: AlthoughSaccharomyces cerevisiaeis the most frequently isolated species in wine fermentation, and the most studied species, other species and interspecific hybrids have greatly attracted the interest of researchers in this field in the last few years, given their potential to solve new winemaking industry challenges.S. cerevisiaexS. kudriavzeviihybrids exhibit good fermentative capabilities at low temperatures, and produce wines with smaller alcohol quantities and larger glycerol quantities, which can be very useful to solve challenges in the winemaking industry such as the necessity to enhance the aroma profile.

Methods: In this study, we performed a transcriptomic study ofS. cerevisiaexS. kudriavzeviihybrids in low temperature winemaking conditions.

Results: The results revealed that the hybrids have acquired both fermentative abilities and cold adaptation abilities, attributed toS. cerevisiaeandS. kudriavzeviiparental species, respectively, showcasing their industrially relevant characteristics. For several key genes, we also studied the contribution to gene expression of each of the alleles ofS. cerevisiaeandS. kudriavzeviiin theS. cerevisiaexS. kudriavzeviihybrids. From the results, it is not clear how important the differential expression of the specific parental alleles is to the phenotype of the hybrids.

Conclusions: This study shows that the fermentative abilities ofS. cerevisiaexS. kudriavzeviihybrids at low temperatures do not seem to result from differential expression of specific parental alleles of the key genes involved in this phentoype.
Quantification of polysaccharides fixed to Gram stained slides using lactophenol cotton blue and digital image processing
Authors: Ericksen Bryan
Published: May 2017

Dark blue rings and circles emerged when the non-specific polysaccharide stain lactophenol cotton blue was added to Gram stained slides. The dark blue staining is attributable to the presence of capsular polysaccharides and bacterial slime associated with clumps of Gram-negative bacteria.  Since all bacterial cells are glycosylated and concentrate polysaccharides from the media, the majority of cells stain light blue. The contrast between dark and light staining is sufficient to enable a digital image processing thresholding technique to be quantitative with little background noise. Prior to the addition of lactophenol cotton blue, the Gram-stained slides appeared unremarkable, lacking ubiquitous clumps or stained polysaccharides.  Adding lactophenol cotton blue to Gram stained slides is a quick and inexpensive way to screen cell cultures for bacterial slime, clumps and biofilms that are invisible using the Gram stain alone.  The presence of cell clumping provides a possible explanation of the presence of persisters and paradoxical points observed in Virtual Colony Count antimicrobial assays, and suggests a phenotypic resistance mechanism to antimicrobial peptides involving capsular polysaccharides.
La autoría mediata en el asesinato del obispo Enrique Angelelli de La Rioja, perpetrado por el terrorismo de Estado en Argentina
Authors: Lascano Carlos Julio
Published: May 2017

El presente artículo analiza la aplicación de la teoría de Roxin sobre la autoría mediataa través de aparatos organizados de poder, en el caso del asesinato del obispode La Rioja (Argentina), Enrique Angelelli, cometido en 1976 por el terrorismo deEstado en Argentina en el contexto del plan sistemático de aniquilación de opositoresal régimen militar. La singularidad de este caso radica en la simulación de unaccidente automovilístico para ocultar el delito.
El derecho a no ser discriminado o a vivir como iguales
Authors: Morell Sanz Ana
Published: May 2017

Este trabajo es resultado de la creencia de que el origen de gran parte de los malesactuales que infligen a la humanidad tiene su raíz en la discriminación. En este artículo se lleva a cabo una fundamentación de los Derechos Humanos en el derecho a no ser discriminado como principio moral sustantivo y su necesaria traducción en un principio procedimental discursivo no discriminatorio, que articulará el foro en el que concreta un catálogo de derechos, sin olvidar tener en cuenta las razones proporcionadas por las potencialidades humanas básicas a satisfacer.
El amor en un mundo de opresión: Aportes de la Teología de la Liberación a la reflexión sobre las relaciones entre justicia y misericordia
Authors: Caram María José
Published: May 2017

Este artículo se pregunta por las relaciones entre la justicia y la misericordia, ypartiendo de la constatación del inmenso sufrimiento injusto de pueblos y personasen América Latina. Luego indaga cómo la Teología de la liberación, a la luz delas fuentes bíblicas y de la lectura que de ella hacen las comunidades cristianasde América Latina, ha concebido el vínculo entre la justicia y el amor. La llamada“opción preferencial por los pobres” y el reconocimiento de la autoridad de las víctimas son expresiones de cómo la fe cristiana concibe la inseparabilidad de la justicia y el amor. Finalmente, expone cómo la misericordia puede ser considerada como un principio de acción concreta y urgente, capaz de instaurar la justicia, trastocando la inhumanidad en humanidad.
Mirada de la Gestión moderna desde la teoría a del caos y la transdisciplina
Authors: SALAZAR  DUQUE OSCAR
Published: May 2017

La humanidad  y sus organizaciones del siglo XXI observan con inquietud los episodios  turbulentos y de desorden que generan incertidumbre y caos en los aspectos sociales, políticos, ecológicos, tecnológicos, científicos y en la gestión, entre otros. Muchos visualizan, en medio de esas manifestaciones, señales que  se  deben aprovechar como oportunidades para replantear a través de la innovación  y generación de nuevos productos  y servicios, el rumbo de las organizaciones en procura de atender los aspectos de insatisfacción de los clientes y demás partes interesadas. La mirada alterna y diferente frente a los  escenarios descritos, permite superar los paradigmas  de la gestión tradicional al considerar que el universo, la sociedad y las organizaciones comparten como sistemas abiertos un complejo entramado de variables interdependientes, generadoras de sinergia, pero también expuestas al desorden y al caos que  reta a los líderes empresariales al diseño de estrategias de gestión con un  abordaje y alcance  transdisciplinar que les permita visualizar, intervenir y minimizar los efectos indeseables que pueden atentar contra la estabilidad y desarrollo de sus instituciones.   Palabras clave: Paradigmas, Complejidad, Entorno, Orden – Desorden, Caos, Gestión, Turbulencia, Transdisciplina  y Organizaciones.
Caring for people with dementia at end of life
Authors: Lillyman Sue , Bruce Mary
Published: May 2017

Dementia affects everyone differently. In this article, Sue Lillyman and Mary Bruce explain how, by understanding the condition and using a person-centred approach, appropriate end-of-life care can be given in their preferred place
The law on reading personal emails sent during work hours
Authors: Ashwood Lee
Published: May 2017

In 2016, the European Court of Human Rights found that employers can legally read the personal messages an employee sends during work hours, in some circumstances. Lee Ashwood explains how this ruling applies to those working in adult social care
Learning from others: a review of two recent care home ratings
Authors: Frankova Helena
Published: May 2017

Despite the Care Quality Commission being clear on what it expects from care providers, many are still falling short. In this article, Helena Frankova compares two recently inspected care homes and highlights what can be learned from their experiences
Completing revalidation: writing reflective accounts
Authors: Ashurst Adrian
Published: May 2017

Writing reflective accounts is an integral part of completing the revalidation process. In this article, Adrian Ashurst outlines the requirement for this process, explaining how and why they should be written
A critical friend: Addressing special measures
Authors: Hancock Dave
Published: May 2017

The Royal College of GPs Peer Support Programme provides mentoring for practices placed in special measures after inspection. Dave Hancock spoke to Jayne Dewhurst, Deputy Project Lead, about how the programme is helping practices get back on track
A guide to GP practice premises
Authors: Conlan Paul
Published: May 2017

Practice Management spoke to Paul Conlan at GP Surveyors about the issues and challenges facing practice managers with premises leasing and the best ways to keep practices profitable
Asthma management in general practice
Authors: Cornforth Amber
Published: May 2017

Every asthmatic patient is different and needs to receive individually tailored evidence-based management advice and care to attain the best possible outcomes, says Amber Cornforth
Should our federation become a super practice?
Authors: Cumberlege Justin
Published: May 2017

Justin Cumberlege, a healthcare specialist at law firm Cripps, looks at the reality of establishing a super practice
Time to re-energise your practice?
Authors: McIntyre Gaynor
Published: May 2017

Gaynor McIntyre offers five top tips on getting your practice fit and ready to deal with every business challenge
Friendship in the Hebrew Bible
Authors: Olyan Saul M.
Published: May 2017

Friendship, though a topic of considerable humanistic and cross disciplinary interest in the contemporary academy, has mainly been ignored by scholars of the Hebrew Bible, possibly on account of its complexity and elusiveness. Yet friendship in the Hebrew Bible warrants the kind of thorough, detailed exploration that friendship has received from specialists in neighboring fields such as Classics and New Testament and in any number of other fields. The author of this book provides an in-depth, theoretically engaged, philologically grounded, and contextually sensitive study of friendship in the Hebrew Bible. It is the first book-length study of its kind, filling in a significant gap in our knowledge and understanding of the constellation of social relationships represented in biblical texts and contributing to contemporary, incipient cross-disciplinary theorizing of friendship. Topics covered include how the expectations of friends and family members overlap and differ, including what makes the friend a distinct social actor; failed friendship; friendships in narrative such as those of Ruth and Naomi, Jonathan and David, and Job and his three comforters; and friendship in the second century BCE Hebrew wisdom text Ben Sira, including how Ben Sira’s notions of friendship relate to ideas expressed in earlier biblical texts and in Greek sources.
The House of the Mother
Authors: Chapman Cynthia R , Collins John J
Published: May 2017

This book reevaluates the biblical house of the father (bêt ’āb) in light of the anthropological critique of the patrilineal model. It uncovers and defines the contours of an underappreciated yet socially significant kinship unit in the Bible: “the house of the mother (bêt ’ēm).” Identified with what anthropologists call “the uterine family,” the biblical house of the mother comprised a mother, her maidservants, and her biological and adopted children. The house of the father subdivided into maternally named or maternally identified units. Members of a maternally named house formed an alliance within the larger house of the father and competed as a unit for succession within the house of the father. Biblical Hebrew recognizes these maternal units with kinship labels specific to a mother and keyed to female reproductive organs: “son of my womb,” “the child who opens the womb,” “my brother, the son of my mother,” “a brother, one who had nursed at my mother’s breasts.” We also find maternally delineated space within the house of the father described as a “house,” “chamber,” or “tent” of the mother, and this space is associated biblically with conception, birth, breastfeeding, and marriage negotiations. This book demonstrates that the Bible recorded its past in the form of idealized, founding-family narratives, and within those narratives, competing mothers and their sub-houses marked hierarchies within the house of the father and political divisions within the national house of Israel.
4Hz mechanical vibration relieves pain through Na+/K+-ATPase α3 isoform-dependent brain tissue dehydration
Authors: Musheghyan Gohar , Minasyan Arevik , Arajyan Gohar , Ayrapetyan Sinerik
Published: May 2017

In this work the effect of 4Hz 30dB horizontal mechanical vibration (MV) on thermal pain threshold, hydration and [3H]-ouabain binding in brain and heart muscle tissues of rats was studied. It was revealed that 4Hz MV treatment for 10 minutes increased pain threshold, which was accompanied by brain and heart muscle tissue dehydration. In vitro state, hydration of brain and heart muscle tissues of sham animals was increased, while in 4Hz MV-treated animals the increase of brain tissue hydration was more pronounced and heart muscle tissues were dehydrated. The fact that 4Hz MV treatment also impacted heart muscle tissue hydration indicates that 4Hz MV effect on brain and heart muscle tissues is realized through a common messenger circulating in blood. The incubation of brain and heart muscle tissues in PS containing 10-4M and 10-9M ouabain led to tissue hydration in sham and 4Hz MV-treated animals. However, tissues of 4Hz MV-treated animals were less hydrated, and this hydration was accompanied by the decrease and increase of membrane receptors’ affinity at 10-4M and 10-9M ouabain concentrations, respectively. Based on the obtained data, it is suggested that pain-relieving effect of 4Hz MV is due to α3 isoform-dependent brain tissue dehydration.
IMPACT ANALYSIS OF IT USE IN LOGISTICAL COSTS OF A BRAZILIAN BEVERAGE COMPANY
Authors: Silva Fabio Aquino da , Oliveira Valmir Martins
Published: May 2017

O objetivo deste artigo é identificar os impactos que o uso de Tecnologia da Informação - TI influencia os custos logísticos de uma empresa de bebidas. A construção de indicadores para avaliar os custos que compõem actividade logística é influenciado por tecnologias utilizadas pela empresa. Este é um estudo de caso único, com os dados obtidos a partir de um questionário respondido por um executivo responsável pela definição da estratégia operacional da empresa. Os principais resultados são suportados pela revisão da literatura que mostra que os indicadores financeiros e operacionais estabelecidos pelo software são importantes para boas práticas de gestão da empresa.
DAIRY PRODUCTION DIAGNOSIS FROM THE PERSPECTIVE OF BUSINESS ECOSYSTEM: STATE OF THE ART IN 2016
Authors: Bonamigo Andrei , Ferenhof Helio Aisenberg , Forcellini Fernando Antonio
Published: May 2017

In the pursuit of identify ways for a better understanding the barriers of the dairy production system, we sought to diagnose them from the perspective of the business ecosystem concept, through a systematic literature review. Thus, we use content analysis to serve as the basis for analysis and discussion of the barriers of dairy production. Resulting a total of fifteen barriers, properly presented and discussed. In addition, we provide some insights to mitigate these barriers. The study presents contribution to the development of dairy production by providing assistance to develop strategies for producers’ cooperatives, government agencies, milk producers, hulling industries products from milk. Based on the perspective of the business ecosystem is possible to have a broader view of the scenario where dairy production occurs and recognize the barriers of dairy production system. And once identified these barriers, it is possible to devise strategies to eliminate or mitigate these barriers.
Opinions of mothers regarding the comminication styles of mothers of children with autism spectrum disorders
Annelerin otizm spektrum bozukluğu olan çocuklarıyla kurdukları iletişim biçimlerine ilişkin görüşleri
Authors: Aktaş Burcu , Çifci Tekinarslan İlknur
Published: May 2017

The aim of this study is to determine the opinions of the mothers of children with Autism Spectrum Disorder (ASD), which can interact with their children. Phenomenology design, a qualitative research model was used in the study. Research data were collected by obtaining information regarding demographic aspects and by using a 15-item semi-structured interview form designed to identify views of mothers with children with Autism Spectrum Disorder (ASD) on their communication styles with their children. 9 mothers with children with Autism Spectrum Disorder (ASD) between the ages of 4-6 participated in the study.  The data were analyzed using the content analysis method. Findings of this study showed that children with Autism Spectrum Disorders (ASD) expressed gestures, facial expressions, pointing and verbally but they have difficulty expressing themselves. Additionally found that ıf they aren’t express themselves, exhibit problem behaviors. Mothers who have children with Autism Spectrum Disorder (ASD), prefer to verbal communication but they have difficulty. Also they organized their communicative behaviors according to the characteristics of their children. The data obtained from the survey results were discussed based on the literature.Extended English abstract is in the end of PDF (TURKISH) file. ÖzetBu araştırmanın amacı, annelerin Otizm Spektrum Bozukluğu (OSB) olan çocukları ile kurdukları iletişim biçimlerine ilişkin görüşlerini belirlemektir. Araştırmada nitel araştırma yöntemlerinden olgubilim desenine yer verilmiştir. Araştırma verileri; demografik bilgiler ve annelerin Otizm Spektrum Bozukluğu (OSB) olan çocukları ile iletişim biçimlerine ilişkin görüşlerini belirlemeye yönelik 15 sorudan oluşan yarı yapılandırılmış görüşme formu kullanılarak toplanmıştır. Elde edilen veriler içerik analizi ile analiz edilmiştir. Araştırmanın çalışma grubunu, 4-6 yaş arasında Otizm Spektrum Bozukluğu (OSB) olan çocuğa sahip 9 anne oluşturmaktadır.  Araştırma sonucunda, Otizm Spektrum Bozukluğu (OSB) olan çocukların kendilerini jest, mimik ve sözel olarak ifade ettikleri ve kendilerini ifade ederken zorlandıkları, ifade edemedikleri durumlarda çeşitli problem davranışlar sergiledikleri bulgulanmıştır. Annelerin ise Otizm Spektrum Bozukluğu (OSB) olan çocukları ile iletişim kurarken sözel ifadeler tercih ettikleri, çocukları ile iletişim kurarken çeşitli güçlükler yaşadıkları, kendi iletişimsel davranışlarını çocuklarının özelliklerine göre düzenledikleri ve çoğunlukla ev ortamında iletişim kurmayı tercih ettikleri bulgulanmıştır.