bluuebunny/crossref_metadata_2025 huggingface dataset:
Pkd1 Mutation Has No Apparent Effects on Peroxisome Structure or Lipid Metabolism
Authors: Terabayashi Takeshi , Menezes Luis F. , Zhou Fang , Cai Hongyi , Walter Peter J. , Garraffo Hugo M. , Germino Gregory G.
Published: July 2021

Key Points

Although fatty acid (FA) oxidation defects have been reported in polycystic kidney disease (PKD), no studies have examined whether peroxisomes contribute to the abnormalities.

We investigated peroxisome biogenesis and FA metabolism in autosomal dominant PKD models and tested whether polycystin-1 colocalized with peroxisome proteins.

Our studies show that loss of Pkd1 does not disrupt peroxisome biogenesis nor peroxisome-dependent FA metabolism.

Background

Multiple studies of tissue and cell samples from patients and preclinical models of autosomal dominant polycystic kidney disease report abnormal mitochondrial function and morphology and suggest metabolic reprogramming is an intrinsic feature of this disease. Peroxisomes interact with mitochondria physically and functionally, and congenital peroxisome biogenesis disorders can cause various phenotypes, including mitochondrial defects, metabolic abnormalities, and renal cysts. We hypothesized that a peroxisomal defect might contribute to the metabolic and mitochondrial impairments observed in autosomal dominant polycystic kidney disease.

Methods

Using control and Pkd1−/−
kidney epithelial cells, we investigated peroxisome abundance, biogenesis, and morphology by immunoblotting, immunofluorescence, and live cell imaging of peroxisome-related proteins and assayed peroxisomal specific β-oxidation. We further analyzed fatty acid composition by mass spectrometry in kidneys of Pkd1fl/fl;Ksp-Cre mice. We also evaluated peroxisome lipid metabolism in published metabolomics datasets of Pkd1 mutant cells and kidneys. Lastly, we investigated if the C terminus or full-length polycystin-1 colocalize with peroxisome markers by imaging studies.

Results

Peroxisome abundance, morphology, and peroxisome-related protein expression in Pkd1−/−
cells were normal, suggesting preserved peroxisome biogenesis. Peroxisomal β-oxidation was not impaired in Pkd1−/−
cells, and there was no obvious accumulation of very-long-chain fatty acids in kidneys of mutant mice. Reanalysis of published datasets provide little evidence of peroxisomal abnormalities in independent sets of Pkd1 mutant cells and cystic kidneys, and provide further evidence of mitochondrial fatty acid oxidation defects. Imaging studies with either full-length polycystin-1 or its C terminus, a fragment previously shown to go to the mitochondria, showed minimal colocalization with peroxisome markers restricted to putative mitochondrion-peroxisome contact sites.

Conclusions

Our studies showed that loss of Pkd1 does not disrupt peroxisome biogenesis nor peroxisome-dependent fatty acid metabolism.
RESEARCH OF EFFECTIVE TRANSPORT AND LOGISTICS LINKS IN THE ORGANIZATION OF INTERNATIONAL MULTIMODAL TRANSPORT MINERAL FERTILIZERS
Authors: Kulikov Aleksey , Bliznyakova Elena
Published: July 2021

Modern agriculture cannot do without the use of mineral and organic fertilizers. Mineral fertilizers are produced by large holdings both in Russia and abroad, and Russian enterprises have subsidiaries distributed throughout the world. The latter factor makes mineral fertilizers one of the most export-oriented branches of the chemical industry in Russia. According to official statistics in 2019 Russian agricultural companies supplied more than 21 million tons of mineral fertilizers to foreign markets, which determines the peculiarities of the country's market.

The purpose of the study is to determine the optimal assignment of consumers to suppliers of mineral fertilizers in the organization of multimodal transportation. The article considers the period of the beginning of the reorientation of the production of mineral fertilizers for export. The issue of creating domestic ports specialized in the transshipment of fertilizers has been studied. The volumes of production and consumption of specific countries and regions that are included in export-import operations with each other are analyzed. Routes of transportation of fertilizers with determination of the shortest distances are studied. The optimization of the existing route option for the delivery of nitrogen and potash fertilizers to Brazil is proposed.
Identity Constructions and Gender in Daisy Hasan’s The To-Let House
Authors:   Department of English, Sikkim University, Samdur, P. O, Tadong, Gangtok, Sikkim 737102, India., Murshida Afrida Aainun
Published: July 2021

This paper is a detailed Critical Discourse Analysis (CDA) of the novel The To-Let House that represents the indigenous struggles, the politics of identity and the construction of a ‘woman’s identity’ amidst the unsettling environment of violence in the historical context of the North Eastern part of India. The paper would analyse and explore the underlying discourse operating in the novel and investigate the core theories and its impact through the conscious choices of the ‘language in use’ by the author. Daisy Hasan’s The To-Let House is primarily marked with the identity constructions and its gradual evolution. The author not only just unravels the struggles that the characters undergo but also counterfeits a sense of identity instituting it towards one’s self identity. The characters in the novel are unable to affiliate themselves into any one particular cultural identity; rather they constantly are struggling within themselves inwardly, in the midst of the violence surrounding them outwardly. This weakness and inability to assign an identity turns out to be a strong narrative that constructs a powerful discourse highlighting the nuances of ‘belongingness.’
Review on the Child in Modern Iraqi Poetry
Authors:   Department of Arabic, College of Education for Girls, Kufa University, Iraq., Hasan Muna Salah
Published: July 2021

The image of the child in its various shades is one of the common images in Arabic poems from the pre-Islamic era to the modern era, but it did not receive the attention of scholars, and it was not studied in depth showing its connotations and symbols. Hence came my study entitled "The Child in Contemporary Iraqi Poetry", which is an attempt to clarify the symbols of the word (the child) and what it indicates according to the context in which they are mentioned, as well as the statement of the aesthetic aspects of how to employ these symbols through the selection of poetic texts of modern poets in which the image of the child was mentioned Where this image was linked to the intellectual and political framework of the trends of Iraqi poets to create with it multiple connotations that were in harmony with the successive conflicts and revolutions that the poet employed to express intellectual, political and artistic positions. Modern Iraqi poetry by this expression means what many poets wrote in a non-traditional or traditional (classical) poetry curriculum in the literature of their languages. It appeared in Arabic literature at the end of the first half of the twentieth century, especially at the hands of Al-Rihani, Al-Sayyab, the angels and the Arab diaspora in a number of European countries that they went to settle in, especially Italy, France, Britain and then the American states. One of the most prominent differences raised by this trend was what was raised about (authenticity and contemporary) in his book and its production, over decades of years, which lasted about a century.
Analisis Teknis Usaha Pembuatan Pupuk Organik Dari Kotoran Ayam
Authors: Susriyati
Published: July 2021

Peternakan ayam H.Mangkuto merupakansalah satupeternakan penghasil limbah yang cukup besar di Lintau Buo dan limbah yang dimaksud adalah kotoran ayam. Limbah jenis ini dapat menyebabkan polusi udara dan akan mengganggu kesehatan manusia tentunya. Dari kondisi tersebut maka peneliti terinspirasi untuk mengolahlimbahdengankatalainkotoranayammenjadisesuatuyangbernilaijualdengancaramengolahkotoranayaminimenjadipupukorganiksecaraaerobdenganteknologirendahdalambentukremah,kemudianmengetahuikadarairdanPHpupukorganiktersebutberdasarkanparameteridealpupukorganik.Danhasilyangdiperolehdaripenelitianiniadalahpupukorganikdalambentukremahdengankadarair32,98%danPH9,30danusahainimemanglayakuntukdikembangkankarenabaikuntukkesehatandanramahlingkungantentunya.
Implementasi System Persediaan dengan Metode Grafik dan Penerapan Last In First Out pada Hasanah Collection
Authors: Arief Wisky Irzal
Published: July 2021

The purpose of this research is to produce applications that can provide information about inventory, because this is very important in the world of organizations engaged in marketing and selling goods. So from that the authors conducted research on hasanah collection, implementation is applied to determine improving the ability of the inventory system in scheduling and selling processes. For this reason, a computerized system  was built so as to minimize the calculation error to determine the amount of ending inventory in hasanah collection.
Pemberian Layanan Informasi untuk Meningkatkan Kedisiplinan Siswa Kelas Xi IPS 2 di SMA Negeri 4 Bukittinggi
Authors: Nelita Elfa
Published: July 2021

Penelitian ini bertujuan untuk mengetahui bagaimana peningkatan kedisiplinan siswa setelah diberikan Layanan Informasi di kelas XI IPS 2 SMA Negeri 4 Bukittinggi. Metode pengumpulan data untuk mengetahui tingkat kedisiplinan siswa, digunakan teknik pengumpulan data dengan memakai metode kuesioner. Untuk mengetahui persentase tingkat disiplin siswa, maka dilakukan analisis statistik deskriptif. Penelitian dirancang dalam dua siklus yang masing-masing siklus pertama terdiri dari perencanaan tindakan, pelaksanaan tindakan, observasi, dan refleksi, sedangkan siklus kedua terdiri dari perencanaan tindakan, pelaksanaan tindakan, observasi, dan refleksi. Dari hasil penelitian dan pembahasan dapat disimpulkan bahwa pada siklus pertama masih banyak terdapat siswa yang melanggar kedisiplinan sekolah dan peraturan lainnya dengan rata-rata 28,48% kemudian terjadi peningkatan pada siklus ke II dan tidak beberapa orang siswa yang melanggar, dan sudah mengalami perubahan dari siklus I ke siklus II dengan rata-rata 7,88%. Dengan demikian, pemberian Layanan Informasi dapat meningkatkan kedisiplinan siswa XI IPS 2 SMA Negeri 4 Bukittinggi.
Analisis Wacana Kritis Pada Berita Kriminal Surat Kabar Posmetro Padang
Authors: Silvia Permata Sari
Published: July 2021

Understanding of the hidden intent or meaning behind the news texts can be known through critical discourse analysis. The basic understanding of critical discourse analysis is that discourse is not understood merely as an object of study of language but language as a tool used for certain purposes and practices including ideological and power practices. The data of this research are news texts with criminal problems in the newspaper Posmetro Padang. The source of this research data is the daily news of Posmetro Padang. Theo van Leeuwen's critical discourse analysis model is one of six critical discourse analysis models that allow the reader to know how a group or someone is marginalized or even favored in a news discourse. In addition, it helps so that readers can think more critically in analyzing a news discourse. Not only read but understand and interpret it so that it can know the hidden purpose in the news text.
Perancangan Grafis Lingkungan Perkantoran Gunung Kembang Pemerintah Kabupaten Sarolangun
Authors: Widia Marta  , Zahrir Fahmi
Published: July 2021

Grafis Lingkungan Perkantoran Gunung Kembang Pemerintah Kabupaten Sarolangun dalam Perancangan Desain Komunkasi Visual menggunakan media sign system yang berfungsi untuk menunjuk lokasi, mengidentifikasi, menginformasikan kantor dan fasilitas yang ada di komplek perkantoran Gunung Kembang. Pada perancangan ini, data yang di gunakan adalah Grafis Lingkungan dalam bentuk sign system metode perancangan menggunakan wawancara, observasi, dokumentasi, buku, dan internet Perancangan ini memakai teori SWOT dengan berupa media utama yang di rancang adalah welcome Sign, wayfinding Sign, wayshowing sign, wall mounted sign, warning regulatory, identified sign, map sign, directioan sign, dan peta aplikasi media untuk menginformasikan kepada masyarakat Perkantoran Gunung Kembang
Pusat Informasi Pada Perusahaan Daerah Air Minum (PDAM) Kota Padang Berbasis Web
Authors: Harkamsyah Andrianof
Published: July 2021

Pemanfaatan teknologi informasi pada PDAM Padang belum optimal, tidak terkecuali pada pengolahan informasi kepada pelanggan yang masih manual. Sehingga menyebabkan informasi yang dibutuhkan tidak efektif dan efesien. Jadi dari hal tersebut penulis mencoba memberikan solusi dengan membangun sebuah sistem informasi pengolahan informasi serta proses transaksi pembayaran tagihan PDAM yang bertujuan untuk membantu atau mempermudah admin dalam melakukan pengolahan data informasi dan pelanggan dalam memperoleh informasi serta mengetahui tarif pembayaran.

Penelitian perpustakaan dan penelitian laboratorium dimana data-data yang diperoleh dikelompokkan terlebih dahulu lalu dalam analisa dan hasil yang digunakan adalah Unified Modelling Language (UML) yang mana diantaranya, Use Case Diagram, Class Diagram, Sequence Diagram, Aktivity Diagram, Collaboration Diagram, dan Deployment Diagram dan aplikasi yang dibangun menggunakan bahasa pemrograman HTML dan PHP Skrip. Sedangkan database yang dipakai adalah MySQL. Dengan pemanfaatan sistem komputerisasi diharapkan penerapan forum e-raport ini nantinya akan mampu mempermudah guru dan siswa dalam proses penilaian hasil pembelajaran serta dalam mendapatkan informasi yang lebih baik dan berkualitas. Sehingga tujuan yang diharapkan untuk kemajuan siswa dan sekolah dapat tercapai
Dimensi Edukasi Dalam Ungkapan Larangan Masyarakat Minangkabau
Authors: Noni Febriana  , Robby Dharma
Published: July 2021

Artikel ini ditujukan untuk mendeskripsikan dimensi edukasi yang terdapat dalam ungkapan larangan masyarakat Minangkabau. Penelitian ini merupakan jenis penelitian kualitatif deskriptif dengan menggunakan teknik analisis isi. Penelitian ini dilakukan pada empat tempat di kota Padang, yaitu: Padang Barat, Padang Timur, Padang Utara, dan Padang Selatan. Data penelitian ini adalah ungkapan larangan masyarakat Minangkabau yang dikumpulkan melalui hasil observasi dan wawancara dengan penghulu, cerdik pandai, dan alim ulama. Berdasarkan hasil penelitian dan pembahasan disimpulkan dua hal. Pertama, bentuk ungkapan larangan masyarakat Minangkabau dapat direkonstruksi berdasarkan pelanggarnya, yaitu: wanita hamil, anak perempuan, dan anak laki-laki. Kedua, dimensi edukasi ungkapan larangan masyarakat Minangkabau juga dapat direkonstruksi berdasarkan tindakan, yang terdiri atas tiga dimensi edukasi, yaitu pekerjaan, pertanda, dan kesehatan tubuh. Dimensi edukasi yang terkandung dalam ungkapan larangan masyarakat Minangkabau ditujukan untuk semua orang dan berfokus pada konteks dan perbuatan yang dilanggar, seperti: duduk, menyapu, bermain, bekerja, berjalan, makan, dan aktivitas keseharian lainnya yang terlihat tidak etis atau sumbang.
Pengaruh Budaya Konsumerisme Terhadap Masyarakat Kota
Authors: Tedy Wiraseptya  , Melisa Suardi
Published: July 2021

Urban society as modern society does not only consume functional basic needs to survive. But fulfilling needs that are becoming a desire of urban society. The birth of the culture of consumerism is currently making rapid changes to the city community. However, not all urban communities accept this change. therefore, it is not uncommon to fight arguments and violence resulting from changes in consumerism. This culture of consumerism is motivated by the emergence of a period of capitalism which is carried by liberalism. The emergence of a culture of consumerism has a positive and negative impact. Has a positive impact when the employment field increases, the birth of new technology and others. The negative is when hedonism, consumerism, capitalism, and others arise.
Sistem Pakar Diagnosis Kelainan Sistem Pencernaan Pada Anak dengan Metode Dampster Shafer
Authors: Yuki Saputra  , Sumijan  , Abulwafa Muhammad
Published: July 2021

Adapun permasalahan yang sering terjadi pada anak adalah sebagai berikut: Gumoh, disfagia, Cyclic vomiting syndrome, Kolik, Diare, Sembelit. Dempster-Shafer adalah suatu teori matematika untuk pembuktian berdasarkan belief functions and plausible reasoning (fungsi kepercayaan dan pemikiran yang masuk akal), yang digunakan untuk mengkombinasikan potongan informasi yang terpisah (bukti) untuk mengkalkulasi kemungkinan dari suatu peristiwa. Teori ini dikembangkan oleh Arthur P. Dempster dan Glenn Shafer. Secara umum teori Dampster-Shafer ditulis dalam suatu interval Belief, Plausibility (Triara Puspitasari et al,2016). Mampu menghasil jenis penyakit yang dialami pasien dan memberikan rekomendasi pengobatan apa yang harus dilakukan oleh pasien
Perkuatan, Perbaikan dan Mutu Bahan untuk Bangunan Sederhana di Perumahan Mekar Melati Kelurahan Lubuk Minturun Kota Padang Pasca Gempa Sumatera Barat 2009
Authors: Rafki Imani  , Sofia Anita  , Sonya Ostha Laurency  , Ariani Wulan Putri  , Afif Okriwa  , Fauzi Deca Putra  , Fakhru Rozi  , Romi Eka Putra
Published: July 2021

Gempa Sumatera Barat pada 30 September 2009 yang turut melanda Kota Padang telah mengakibatkan sebagian besar bangunan mengalami rusak berat dan ringan. Makalah ini membahas jenis kerusakan, perbaikan dan perkuatan bangunan rumah warga di Perumahan Mekar Melati Kelurahan Lubuk Minturun Kota Padang, Sumatera Barat. Pengambilan data dilakukan dengan survei dan asesmen secara langsung, baik rumah yang mengalami rusak berat maupun rusak ringan. Pascagempa 2009 bangunan rumah warga di perumahan Mekar Melati Kelurahan Lubuk Minturun, umumnya banyak mengalami rusak berat dan juga rusak ringan. Penyebabnya adalah karena bangunan di sana termasuk kategori rumah yang sangat sederhana (RSS). Material bangunan yang digunakan tidak memakai slof, apalagi dinding yang hanya menggunakan bahan hollowbrick, dimana bahan tersebut jika tidak diplaster maka akan menjadi rapuh sehingga mengakibatkan bangunan mudah runtuh.
Evaluasi Rasionalitas Penggunaan Obat Anti Inflamasi Non Steroid (OAINS) Di Puskesmas Poli-Polia Kabupaten Kolaka Timur
Authors: Ridwan Bai Athur , Fety Yulli , Nurlinda Nurlinda
Published: July 2021

Nyeri didefinisikan sebagai perasaan tidak menyenangkan bagi sebagian orang akibat dari kerusakan jaringan, sehingga pasien melakukan pengobatan dan kebanyakan masih berpusat pada terapi farmakologis seperti penggunaan Obat Anti Inflamasi Non Steroid (OAINS). Adanya efek samping yang bisa terjadi maka perlu ditunjang dengan penggunaan yang rasional khususnya pada fasilitas kesehatan. penelitian ini bertujuan untuk mengetahui gambaran rasionalitas penggunaan OAINS di Puskesmas Poli-Polia Kabupaten Kolaka Timur. Jenis penelitian ini merupakan penelitian non eksperimental dengan desain deskriptif retrospektif. Sampel diambil dengan cara total sampling dari populasi yang memenuhi kriteria inklusi yaitu OAINS tunggal maupun kombinasi yang digunakan pasien periode Januari – Maret 2020 dan memiliki data rekam medik lengkap. Jumlah sampel yang diperoleh yaitu sebesar 72 pasien dan datanya dikumpulkan dalam lembar pengumpul data yang memuat identitas pasien, nama obat, dosis, dan aturan pakai. Analisis rasionalitas penggunaan OAINS dinilai dari aspek ketepatan pemilihan obat, ketapatan jumlah, dan ketepatan dosis dan frekuensi  yang disajikan secara deskriptif. Hasil penelitian menunjukkan bahwa rasionalitas penggunaan OAINS di Puskesmas Poli-Polia Kabupaten Kolaka Timur tidak seluruhnya tepat. Pada aspek tepat pemilihan obat diperoleh sebesar 86%, tepat dosis dan frekuensi pemberian sebesar 83%, dan tepat jumlah obat mencapai 100% dan secara keseluran bahwa OAINS yang digunakan di Puskesmas Poli-Polia Kabupaten Kolaka Timur belum rasional.
Why Research Productivity Among Women in Academia Suffered During the Early Stages of COVID-19 Crisis: A Qualitative Analysis
Authors: Lambrechts Agata A. , Larasatie Pipiet , Boutelier Stefani , Guta Hala A. , Leonowicz-Bukała Iwona , Martinez-Suarez Alpha , Prashad Shikha
Published: July 2021

The discourse on research productivity during the early months of COVID-19 has been dominated by bibliometric and quantitative studies highlighting the fewer publications from women scholars compared to men, but few considered the reasons behind this phenomenon. This paper offers new empirical insights into the experiences and perceptions of women scholars during the early stages of the pandemic using the feminist standpoint theory approach to understand why they have been seemingly less productive. Our findings, based on 101 qualitative survey responses, illustrate the centrality of support with respect to childcare, professional-emotional support from peers and mentors that were lost. Restricted access to institutional facilities, resources, loss of structure, additional time required to prepare for online teaching, and increased service load have negatively impacted research productivity. These factors are compounded by poor mental health with high cognitive and emotional tolls, resulting in depleted resources for the intellectually demanding research activities. Conversely, some women scholars, particularly those without care responsibilities, reported reduced commutes, fewer meetings, and flexible working hours, resulting in unchanged or increased research productivity. As the impact of the pandemic is ongoing, it is critical to assess the underlying causes of reduced productivity of women scholars to mitigate these effects.
Elity w Imperium Osmańskim w XVI w. w świetle traktatu Teodora Spandounesa pt. O pochodzeniu Cesarzy Osmańskich
Authors: Wróbel Piotr
Published: July 2021

Teodor Spandounes urodził się w połowie XV w. w rodzinie greckich emi­grantów, która po upadku Konstantynopola znalazła schronienie we Wło­szech. Ród Spandounesów nie odegrał znaczącej roli w historii Cesarstwa Bizantyjskiego, ale matka Todora, Eudoksja, pochodziła ze znanej rodziny Kantakuzenów. Teodor nawiązał bliskie stosunki z papieżami Klemen­sem VII i Pawłem III, którym doradzał w sprawach osmańskich. Prawdopo­dobnie około 1515 r. Spandounes napisał pierwszą wersję traktatu: O pocho­dzeniu Cesarzy Osmańskich. W 1538 r. zadedykował ostateczną wersję delfinowi Francji Henrykowi. Jak sugeruje tytuł, głównym celem traktatu Spandounesa było wyjaśnienie, w jaki sposób Turcy, w stosunkowo krótkim czasie, rozbu­dowali swe państwo od skromnych początków do obecnego, potężnego stanu. W artykule dokonano analizy przydatności traktatu Spandounesa jako źródła do badań nad elitami w Imperium Osmańskim. Autor doszedł do następu­jących konkluzji: 1) Traktat jest obfitym źródłem wiadomości na temat sze­roko pojętych elit w Imperium Tureckim. 2) Autor jest dobrze poinformowany i jednocześnie krytycznie podchodzi do informacji, jakie uzyskał. Przed­stawiając dzieje sułtanów, opiera się nie tylko na wiadomościach ze źródeł zachodnich, ale zdaje się znać (przynajmniej w jakimś stopniu) historyczną tradycję turecką. 3) Dzieło Spandounesa dostarcza szczególnie cennych wia­domości na temat organizacji dworu sułtańskiego, struktury, kompetencji urzędników dworskich i państwowych oraz organizacji wojskowej. 4) Bardzo cenne są spostrzeżenia Teodora na temat życia codziennego elit w państwie sułtańskim (wystrój wnętrz, ubiór, posiłki itp.).
Critical Thinking – the Basic Competency for Leadership in the 21st century
Authors: Knap‑Stefaniuk Agnieszka , Ambrozová Eva
Published: July 2021

Critical thinking is the necessary competence for the processes of cognition, decision‑making, and taking‑action by managers. Its importance is increas­ing as fast, and relatively easy access to information of different quality and importance in terms of its possible impact can lead to decision paralysis or cognitive dissonance or result in an easier manipulation and influence. The article includes the essential aspects of critical thinking and the possibilities of developing and improving critical thinking in preparing students to be good leaders in the future.
The Turmell-Metre: Using Draw Wire and Inertial Sensors for an In Vivo Ankle Kinematics Study
Authors: Riaño Julio Hernando Vargas , Valera Ángel , Agudelo Óscar
Published: July 2021

This work presents a device for the ankle kinematics study. It is
portable, affordable and some parts can be 3D printed. It is based on
the ankle anatomy and biomechanics, also, it can be applied for the
characterization of the ankle axis or another models of the ankle.
Ludovica Torelli e lo Specchio interiore di fra’ Battista da Crema
Authors: Murano Giovanna
Published: July 2021

The Specchio interiore (Interior Mirror) is a work by the dominican Fra' Battista da Crema partly dedicated to the theme of mystical union. Written close to the foundation, in 1522, of the Hospital of the Incurables in Venice, it remained unpublished for almost two decades and it was first published in 1540 thanks to Ludovica Torelli, countess of Guastalla (1499-1569), alias Paola Maria. Widow, for the second time at age twenty-eight, Ludovica Torelli enjoyed an unusually powerful position for a women. Forced to sell her small state to Ferrante Gonzaga, she spent the second part of her life founding religious institutions and hospitals in Milan and other cities in northern Italy.
I gesuati a Chiusi
Authors: Mignoni Giovanni
Published: July 2021

The presence of the Gesuati in Chiusi, although limited in size and length of time, developed beyond all expectation. At the beginning of the seventeenth century the followers of the Blessed Colombini were called to officiate at the church of the “Madonna della Quercia al Pino” in the countryside just outside Chiusi. The friars arrived at a difficult moment after other religious orders had relinquished the post. The Gesuati did their utmost for the spiritual good of the faithful as well as the material good of the church. Unfortunately after only a few years, the Bishop of Chiusi entrusted the building to a secular priest effectively closing the little convent. The conflict which followed between the church, the diocese and the municipality only worsened the situation to the deep regret of the faithful.
Eziologia di una leggenda. Ipotesi sul culto fiorentino di san Cresci compagno di san Miniato
Authors: Benvenuti Anna
Published: July 2021

The essay analyses the cult of St. Cresci and its origins. St. Cresci is considered to be one of the companions of St. Miniato, and it is believed he was martyred ‘sub Decio’ in the 3rd century. St. Cresci’s legend must be interpreted in the context of the Florentine hagiographic production of the 11th century, when the local clergy tried to resuscitate old and long forgotten cults of saints whose relics they possessed. The paper argues that the legend of St. Cresci was ‘invented’ to be opposed to that of St. Miniato. Indeed in the 11th century Ildebrando, bishop of Florence, strongly promoted the cult of Minias in order to support his claims on the lands of the newly founded monastery. It was after this that cathedral’s canons, in opposition with their bishop, proposed the martyrial figure of St. Cresci; the cult of which got a great importance under the Medici, and especially during the reign of Cosimo III.
Gregorio XI e la rinascita di San Miniato al Monte. Un esempio di riforma monastica promossa nel Trecento dai monaci di Monte Oliveto
Authors: Tagliabue Mauro
Published: July 2021

The monastery of San Miniato, formerly Black Benedictine, in 1373 was entrusted to the care of the Monte Oliveto’s monks with the favor of pope Gregory XI. The paper retraces the reasons of this passage of observance, which took place during a difficult period for the city of Florence, engaged in the War of the Eight Saints, and in the context of an almost generalized crisis of Benedictine abbeys, analyzing the resumption of regular life and institutional innovations, such as the temporary mandate of abbots; until the site was abandoned after the mid-sixteenth century.
Alcune note su San Miniato in età medicea
Authors: Cipriani Giovanni
Published: July 2021

The link between San Miniato and the Medici, started in 1448 with the financing of the aedicule destined to host the miraculous crucifix of St. John Gualberto, continued with the artistic commissions of Pope Leo X. The contribution goes in particular into the transformations that the monastic complex underwent, at the behest of the family, during the siege of Florence in 1529-30 and in the following centuries, becoming first a vast fortress, then a lazaret; until the sacred value of the site was recovered from the early eighteenth century, with the creation of the Via Crucis and through the research of the bodies of the martyrs promoted by Grand Duke Cosimo III.
«La Basilica di S. Miniato al Monte sta a noi se si vuole». Il ritorno dei monaci olivetani nel 1924
Authors: Donghi Roberto
Published: July 2021

The paper retraces the negotiations undertaken by the Olivetan monks at the beginning of the 20th century for their return to the ancient abbey of San Miniato al Monte, which they had been forced to abandon in 1552 for the construction of the ramparts to defend the city. Given its location, other religious orders wanted to settle there, such as the Vallombrosans of Santa Trinita and the Cassinesi of the Florentine Abbey, but the Olivetans claimed their rights. So on 11th July 1924 the visiting abbot Benedetto Benedetti signed the deed of delivery to his regular family. The official entrance, disclosed by the town press, took place on Sunday 26 October 1924, and the resumption of the monastic life the following year, under the guidance of Don Gaetano Romagnoli, the first abbot of the restored Olivetan community.
Penyuluhan Pra Nikah Dalam Perspektif Islam Sebagai Upaya Meningkatkan Pengetahuan Tentang Pernikahan Islam
Authors: Israfil Israfil , Salad Muzakir , Aminullah Aminullah , Subakti Subakti
Published: July 2021

Perceraian di NTB makin meningkat diakibatkan maraknya pernikahan dibawah umur (19 tahun kebawah), kurangnya pemahaman tentang hal-hal yang harus persiapkan sebelum melakukan pernikahan. kondisi ini menjadi dasar melakukan pengabdian dengan tujuan meningkatkan pengetahuan dan pemahaman tentang pernikahan islam melalui kegitan penyuluhan Pra Nikah dalam perspektif Islam. Mitra dalam kegitan ini adalah masyarakat desa Gelogor kabupaten Lombok Barat yang berjumlah 20 orang. Metode pelaksanaan dengan ceramah, diskusi dan tanya jawab. Langkah-langkah kegitan perencanaa, tindakan, dan evalusi. Hasil pre test pemahaman mitra tentang pra nikah dalam Perspektif  Islam mendapatkan nilai rata-rata 50 dan hasil posttest rata-rata 90 dengan rata-rata peningkatan 33%. Ini menunjukkan bahwa kegiatan penyuluhan memberikan dampak pada peningkatan pemahaman dan pengetahuan mitra. Meskipun terjadi peningkatan dan pemahaman mitra masih perlu dilakukan sosialisasi dan pempingan secara berkelanjutan.
Pre-Marriage Counseling is an Islamic Perspective as an Effort to Increase Knowledge About Islamic Marriage
Divorce in NTB may increase due to the prevalence of underage marriages (19 years and under), lack of understanding of the things that must be prepared before marriage. This condition becomes the basis for doing service with the aim of increasing knowledge and understanding of Islamic marriage through Pre-Marriage counseling activities from an Islamic perspective. Partners in this activity are the Gelogor village community, West Lombok district, totaling 20 people. The implementation method is lecture, discussion, and question and answer. The steps of planning, action, and evaluation activities. The results of the pre-test of partners' understanding of premarital marriage in the Islamic perspective got an average score of 50 and the posttest results averaged 90 with an average increase of 33%. This shows that the extension activities have an impact on increasing the understanding and knowledge of partners. Although there is an increase and understanding of partners, it is still necessary to carry out socialization and mentoring on an ongoing basis.
Information and analytical system “Spectrum of shadow cash flow distribution”
Authors: Baturina Evgeniya , Litvinenko Aleksandr
Published: July 2021

The structure of the article allows us to reveal the main content of the proposed information and analytical system, in order to provide a reasonable representation of the marker distribution of shadow non-cash cash flow by forming a database on the cash flow in the bank accounts of the studied persons and the practical implementation of the author’s methodology for economic and mathematical modeling of the process of monitoring the minimum value of shadow non-cash cash flow, as one of the main characteristics that identify the shadow economy for a certain period. Based on the review of the main provisions of the scientific literature in the field of countering the legalization (laundering) of criminal proceeds and the financing of terrorism, the qualitative characteristics of the initial data of the proposed information and analytical system are determined. The economic and mathematical tools for analyzing the initial data are considered on the example of the production of economic expertise.
Increased adherence to the treatment of comorbid patients with arterial hypertension and chronic obstructive pulmonary disease on the background of complex therapy
Authors: Menshikova I. G. , Magalyas E. V. , Sklyar I. V. , Loskutova N. V.
Published: July 2021

Aim. To determine the adherence to treatment of patients with arterial hypertension (AH) and chronic obstructive pulmonary disease (COPD) against the background of complex therapy.

Materials and methods. We examined 56 patients with stage II hypertension in combination with COPD. Men accounted for 70%, women – 30%. The average age of patients is 52.9±0.46 years. The patients were prescribed a fixed combination of antihypertensive drugs – telmisartan 40 mg with amlodipine 5 mg and COPD therapy according to GOLD. Patients of group 1 (n=30) studied at a health school against the background of drug treatment, patients in group 2 (n=26) did not attend a health school.

Results. After 6 months of treatment, the number of patients in group 1 increased (p=0.001) regularly taking antihypertensive drugs, 96.7% of patients began to independently control blood pressure and keep a diary of a patient with hypertension. Patients of group 2 showed a statistically significant increase in the level of awareness of the presence of the disease and the awareness of patients about the risk factors for the development of the disease (p=0.01), although the number of patients controlling blood pressure remained low (p=0.1). In group 1, there was a positive trend in terms of the main risk factors, in group 2 the frequency of the prevalence of risk factors practically did not change. By the 6th month of therapy, all patients in group 1 achieved the target blood pressure, in group 2 – in 73.1% of patients. By the end of the observation, in patients of group 1, against the background of the chosen treatment tactics, there was a significantly more significant decrease in left ventricular mass index (LVMI) with its normalization in 33.3% of patients, indicating regression of LV hypertrophy (p=0.01), as well as a significant increase in the ratio of peak velocities on the mitral valve (E/A), (p=0.01), indicating an improvement in LV diastolic function. In group 2, antihypertensive therapy showed a moderate decrease in LVMI (p=0.1) with normalization of this indicator in only 2 (7.7%) of patients. By the 6th month of treatment, an improvement in the parameters of bronchial patency was revealed, however, in the 2nd group of patients, the changes in these parameters were statistically insignificant.

Conclusion. The effectiveness of the treatment of hypertension and COPD depends not only on the choice of the optimal treatment tactics, but also on the patient's compliance with the prescribed therapy regimen. The results obtained indicate a positive effect of the chosen complex treatment regimen on the functional parameters of the left ventricle and bronchial patency.
Clinical and immunological efficiency of dry carbon dioxide baths in patients with asthma and obesity at the ambulatory-polyclinic stage of rehabilitation
Authors: Uksumenko A. A. , Аntonyuk M. V. , Мineeva E. E. , Yurenko A. V. , Khodosova K. K.
Published: July 2021

Introduction. An important part in the rehabilitation treatment of patients with asthma associated with obesity is the ambulatory-polyclinic stage of rehabilitation that includes drug and physiotherapeutic treatment. Recently, dry carbon dioxide baths (DCDB) are increasingly used.

Aim. is to assess the clinical and immunological efficiency of DCDB in the complex rehabilitation treatment of patients with asthma and obesity at the ambulatory-polyclinic stage of rehabilitation.

Materials and methods. The study included 60 patients with asthma and obesity admitted to the departments of medical rehabilitation and clinical examination of scientists of the Medical Association of FEB RAS. Patients of the main group (30 subjects) received DCDB and drug therapy. Patients of the comparison group (30 subjects) received only drug therapy. The DCDB procedures were carried out using the “Reabox” device at CO2 concentration of 15-20%, a temperature of 28-30ºC, 10 procedures. The changes in symptoms, ACQ-5 test, and respiratory function were assessed. The parameters of cellular immunity CD3+, CD4+, CD8+, CD16+, CD19+ and the levels of tumor necrosis factor (TNFα), interleukins (IL) IL-2, IL-4, IL-6, IL-10, IL-17A in the blood were analyzed.

Results. The achievement of asthma control took less time in patients of the main group. The improvement of bronchial patency was evidenced by the positive dynamics of spirometric indices. After DCDB therapy, an increase in suppressive activity of the cellular immunity, a decrease in the levels of pro-inflammatory cytokine IL-4, IL-17A were revealed. The TNF-α/IL-10 ratio statistically significantly changed due to the increase in the level of anti-inflammatory cytokine IL-10. In the comparison group, the positive dynamics was less pronounced.

Conclusion. The use of DCDB increases the clinical and immunological efficiency of the rehabilitation of patients with asthma and obesity at the ambulatory-polyclinic stage. The clinical effect is associated with immunocorrective action, which allows achieving control of the disease in a shorter period of time.
Clinical significance of vitamin d receptor gene polymorphism in children with bronchial asthma
Authors: Potapova N. L. , Markovskaya A. I. , Gaymolenko I. N.
Published: July 2021

Introduction. The development of chronic allergic inflammation of the respiratory tract is determined by various genes. It is assumed that the clinical features of the course of bronchial asthma may be associated with singlet polymorphism of the vitamin D receptor.

Аim. To analyze the frequency of occurrence of polymorphic variants of the VDR-63980G>A gene and evaluate their association with the features of the development and course of bronchial asthma in children.

Materials and methods. To study the association of the VDR-63980G>A gene polymorphism with bronchial asthma in children, 154 patients with bronchial asthma aged 1 to 18 years and 116 healthy subjects were selected. The objective status of the patients was assessed with the clarification of the anamnesis, standard laboratory and instrumental examination. Single nucleotide substitutions were typed by polymerase chain reaction with real-time detection of the results. The genotype distribution was evaluated using the “Gen-Expert” program.

Results. As a result of the association analysis, the relationship of VDR-63980G>A with bronchial asthma in children was established. The presence of genotype -63980AA of the VDR gene increases the risk of developing bronchial asthma in a child by 1.85 times (OR=1.85, [CI 1.02-3.38]; χ 2=4.22, p=0.04). The homozygous genotype -63980GG was more common in the control group – in 49.5% versus 45.4% against the sick children. The genotype of the minor homozygote -63980AA is associated with the early onset of the disease, pronounced obstructive pulmonary ventilation disorders.

Conclusion. The association of genotype -63980AA of the VDR gene with the risk of asthma development in preschool children was revealed.
Fee Simple Failures: Rural Landscapes and Race
Authors: Shoemaker Jessica
Published: July 2021

Property law’s roots are rural. America pursued an early agrarian vision that understood real property rights as instrumental to achieving a country of free, engaged citizens who cared for their communities and stewarded their physical place in it. But we have drifted far from this ideal. Today, American agriculture is industrialized, and rural communities are in decline. The fee simple ownership form has failed every agrarian objective but one: the maintenance of white landownership. For it was also embedded in the original American experiment that land ownership would be racialized for the benefit of its white citizens, through acts of colonialism, slavery, and explicit race-based exclusion in property law. Today, rather than undoing this racialized legacy, modern property rules only further concentrate and homogenize rural landownership. Agricultural landownership remains almost entirely— 98 percent—white. This is a critical racial justice issue that converges directly with our impending environmental crisis and the decline of rural communities more generally.

This Article builds on work of rural sociologists and farm advocates who demonstrate, again and again, that despite a pervasive narrative of rural places dying for want of population and agricultural systems too far gone for reform, the reality is a crowd of emerging farmers—and farmers of color in particular— clamoring for access. Existing policy efforts to support beginning farmers have focused primarily on supporting a few private land transactions within existing systems. This Article brings property theory to the table for the first time, arguing that property law itself is not only responsible for the original racialized distributions of agricultural land but also actively perpetuates both ongoing racialized disparities and the currently industrialized and depopulated rural landscape. This Article deconstructs our most fundamental land-tenure choice—the fee simple itself—and calls on our collective legal imagination to develop more adaptive, inclusive, and dynamic land-tenure designs rooted in these otherwise overlooked rural places.
PAULO FREIRE E A PRESENÇA DOS CAMPONESES E CAMPONESAS EM SUAS OBRAS
Authors: Conte Isaura Isabel , Paulo Fernanda Dos Santos
Published: July 2021

Este artigo objetiva analisar a presença dos camponeses e das camponesas nas obras de Paulo Freire ao longo de sua trajetória. Interessa-nos evidenciar se há essa presença e, ao contexto ao qual Freire se refere ao tratar ou mencionar esses sujeitos. A metodologia adotada é revisão de literatura em livros de Paulo Freire, escrito individualmente, e, assim foram selecionadas dezesseis obras, lidas na íntegra. A escrita se justifica no fato de não haver, disponível, estudo bibliográfico com essa temática. Destacamos como pontos relevantes da pesquisa: Paulo Freire se refere aos camponeses em praticamente todas as suas obras, com destaque ao processo de alfabetização dos camponeses chilenos, a quem mencionou várias vezes, em várias obras; a relação do lugar/classe social/trabalho é central no processo de alfabetização e leitura de mundo; e, a superação da desesperança em substituição à luta que transforma a realidade opressora e antidemocrática.
EXAMINATION OF SECONDARY SCHOOL TEACHERS SELF-ESTEEM AS A DETERMINANT OF THEIR MARITAL ADJUSTMENT IN ANAMBRA STATE
Authors: Chinyelu Nwokolo  , Ada Anyamene  , Edith Muojeke N.
Published: July 2021

Self-esteem as a psychosocial factor that is likely to foretell outcomes like academics, happiness, marital satisfaction and relationships is also a construct that could lead to marital success and happiness. This study examined secondary school teachers’ self-esteem as a determinant of their marital adjustment in Anambra state. Three research questions were posed to guide the study while one null hypothesis was tested at a 0.05 level of significance. A correlational research design was adopted for the study. A sample size of 1,408 married teachers was drawn from a population of 6,987 married teachers. A multi-stage sampling procedure was followed in selecting the study sample. Two instruments: The marital Adjustment Scale (MAS), and Self- Esteem Scale (SES) were used for data collection. The instruments were duly validated by experts in measurement and evaluation and Guidance and Counselling. The reliability coefficient was established thus; 0.85 for the Self-esteem questionnaire, and 0.74 for the Marital Adjustment Questionnaire. Data was collected through a direct delivery approach and was analysed using SPSS version 23. Range of aggregate scores and Pearson correlation coefficients were used to answer research questions and while a t-test was used to test the hypotheses. Findings of the study showed among others there is a non-significant very low positive relationship existing between married teachers’ Self-esteem and their marital adjustment in secondary schools in Anambra State. Based on the study’s findings, it was suggested, among other things, that school Guidance Counsellors organise workshops and seminars for married teachers aimed at fostering healthy self-esteem for successful marital adjustment.
KEYWORDS: self-esteem, marital adjustment, married, teachers, school