bluuebunny/crossref_metadata_2025 huggingface dataset:
Robustness of higher-low order networks with adjustable coupling strength
Authors: Zhang Chengjun , Yang Hao , Yu Wenbin , Chen Yadang , Lei Yi , Yao Hui , Xie Yifan
Published: November 2023

Robustness is one of the most critical characteristics of complex networks, determining their stability and resilience in the face of various disturbances. With the research on complex networks, people have observed that higher-order networks can also affect the structure and function of the network. Therefore, when studying network robustness, we also need to consider the interaction between higher-order networks and low-order networks. To delve deeper into the investigation and comprehension of robustness in complex networks, this paper introduces a model of higher-low order networks with adjustable coupling strength. In this model, network nodes are categorized into autonomous and nonautonomous nodes, with coupling strength adjusted using three methods: random coupling, degree-related coupling, and local coupling. Validation is performed on ER networks, BA networks, SW networks, as well as several real-world networks. The results indicate that as coupling strength increases, network robustness correspondingly diminishes, and the network exhibits intricate percolation behavior.
3-Bridgeness under adding crossings to alternating 3-bridge knots in a 3-bridge representation
Authors: Kwon Bo-Hyun , Kang Sungmo
Published: November 2023

In [B. Kwon and S. Kang, Rectangle conditions and families of 3-bridge prime knots, Topol. Appl. 291 (2021) 107453], using the set [Formula: see text] of all essential alternating rational 3-tangles for positive integer [Formula: see text], the authors showed that all knot diagrams in the numerator closure set [Formula: see text] and the denominator closure set [Formula: see text] with [Formula: see text] are 3-bridge prime knot diagrams. In this paper, for [Formula: see text] we construct a set [Formula: see text] of additions of alternating rational tangles in [Formula: see text]. The set [Formula: see text] generalizes [Formula: see text] and contains it as a subset for some [Formula: see text]. We show that any closure set [Formula: see text] on [Formula: see text] so that the resulting diagrams are reduced and alternating knot diagrams represent alternating 3-bridge prime knot diagrams. Since a tangle diagram in [Formula: see text] is constructed inductively from a tangle diagram in [Formula: see text] by adding only one crossing positively, the result of this paper supports the conjecture that 3-bridge property is preserved under one-crossing alternating addition positively to alternating 3-bridge knots in 3-bridge representations.
Preparation of large-area uniform PdSe2 film and its application in ultrafast fiber laser
Authors: Xie Zhaoru , Chen Jingxian , Huang Jie , Tao Lili , He Junshan
Published: November 2023

In this work, ultrafast Yb-doped fiber laser was realized using multi-layer palladium diselenide (PdSe2) film as the saturable absorber, which was prepared by simple selenization of palladium film deposited by magnetron sputtering method. The prepared polycrystalline PdSe2 film has a thickness of about 12 nm. At a pump power of 180 mW, the obtained mode-locked fiber laser based on the PdSe2 film has a central wavelength of 1063.75 nm, a pulse width of 615 ps, a repetition rate of 17.66 MHz, and an output power of 4.43 mW, respectively. These results indicate that PdSe2 has great potential in applications of ultrafast lasers.
Phonon-assisted upconversion photoluminescence in Mn-doped two-dimensional hybrid metal halides
Authors: Zhao Fuli , Li Junzi , Lin Xiaodong , He Tingchao
Published: November 2023

Phonon-assisted upconversion process is one of the important means to generate upconversion photoluminescence (UCPL), and has important applications in laser refrigeration and other fields. However, until now, the studies on UCPL behavior are still insufficient. Herein, this work synthesizes a series of Mn-doped two-dimensional hybrid metal halide (2D HMH) thin films and investigates their optical properties using various spectral techniques. Raman spectroscopic measurement confirms that Mn-doping is achieved via interstitial doping rather than Pb-substitution. By the measurement of the temperature-dependent PL spectrum, it is found that Mn-doping will weaken the thermal expansion effect of 2D HMHs, but will enhance the electron–phonon coupling strength. More importantly, both two-photon-excited and phonon-assisted UCPL are observed in Mn-doped 2D HMHs, with an extremely large phonon-assisted energy gain (approximately 500[Formula: see text]meV). Our experimental results are of significance for designing phonon-assisted UCPL materials and expanding their applications.
Dual-Attention Based Multi-Path Approach for Intensifying Stock Market Forecasting
Authors: Jadhav Sachin R. , Bishnoi Aashima , Safarova Nodira , Khan Faheem , Aurangzeb Khursheed , Alhussein Musaed
Published: November 2023

In light of the existing challenges in capturing short-term fluctuations and achieving accurate predictions in stock market time series data, this research presents the “Dual-Attention MDWT-CVT-LSTM,” a revolutionary financial time series forecasting model. This model makes use of a dual-attention mechanism in conjunction with a Variant Transformation-Gated Long Short-Term Memory (LSTM) network. The approach relies on the Multilevel Discrete Wavelet Transform (MDWT) to separate stock market index sequences into high-frequency and low-frequency components. Furthermore, a transformative gating mechanism is incorporated into the LSTM, featuring fusion gated units to create the VT-LSTM, effectively addressing abrupt short-term information changes. Within the dual-attention network, VT-LSTM is combined with one-dimensional temporal convolution (Conv1D) to extract spatial and temporal features of data at different frequencies. This facilitates the prediction of various sub-sequences, enabling multilevel and multi-path forecasting research. The experimental evaluation uses diverse models on stock market index datasets and individual stock datasets. The results show the superior prediction accuracy of the proposed model compared to alternative methods, underscoring its practical viability in stock market forecasting applications.
A New Analytical Approach for Nonlinear Global Buckling of Axially Compressed and Tensiled Sandwich Toroidal Shell Segments with CNTRC Coatings and Corrugated Core in Thermal Environment
Authors: Nam Vu Hoai , My Do Thi Kieu , Duc Vu Minh , Giang Nguyen Thi , Hieu Pham Thanh , Phuong Nguyen Thi
Published: November 2023

In this paper, the nonlinear global buckling and postbuckling responses of axially compressed and tensiled sandwich toroidal shell segments with functionally graded carbon nanotube-reinforced composite (FG-CNTRC) coatings and corrugated core in the thermal environment are investigated. Three distributed types of FG-CNTRC coatings with two geometrical types of corrugated core, and three shell types including convex, concave, and cylindrical shells are considered. By adding the thermal forces to the governing equations, a homogenization model for corrugated structures is developed to simulate the thermal and mechanical behavior of the trapezoidal and round corrugated core. The potential energy expression of sandwich shells is established according to the Donnell shell theory with the nonlinearities of deflection, an algorithm to solve the governing equation is developed using the Ritz energy method, and three equilibrium equations are obtained respecting three amplitudes of deflection. The axial critical buckling loads and postbuckling curves of shells can be achieved after some calculations. The numerical examples prove the beneficial effects of corrugated core and CNTRC coatings on nonlinear global buckling responses of sandwich toroidal shell segments significantly.
Amorphous Fe2O3 Porous Films Grown on Multilayer Graphene for High-Performance LIB Anodes
Authors: Fu Hailun , Shan Lan , Wei Ke , Zhou Tao , Xu Junming
Published: November 2023

Amorphous Fe2O3 has special high electrochemical performance as anode materials of LIBs due to its disorderly arranged atoms. However, the issue of its low intrinsic electric conductivity should be solved rationally and facilely. In this work, amorphous Fe2O3 porous films are chemically deposited on the mechanically exfoliated multilayer graphene (MLG) nanosheets, forming a Fe2O3/MLG/Fe2O3 sandwich nanostructure. The addition of 10[Formula: see text]mg of EDTA-2Na is crucial for the formation of amorphous nature and holes in Fe2O3 films on MLG. This composite exhibits better electrochemical performance as LIB anodes than well-crystallized Fe2O3 nanoparticles, amorphous Fe2O3 films without holes and amorphous Fe2O3 isolated nanoparticles on MLG, which are prepared using 0[Formula: see text]mg, 5[Formula: see text]mg, 20[Formula: see text]mg of EDTA-2Na, respectively. The optimized composite delivers a reversible discharge capacity of 1067[Formula: see text]mAh g[Formula: see text] at 100[Formula: see text]mA g[Formula: see text] after 100 cycles. Moreover, a capacity of 522 mAh g[Formula: see text] is delivered at a high current density of 2[Formula: see text]A g[Formula: see text]. The high electrochemical performance of the composite is attributed to the amorphous nature and porous film structure of Fe2O3, and well combination of Fe2O3 and highly conductive MLG substrate.
Fractional Guidance Law with Impact Angle Constraint and Seeker’s Look Angle Limits
Authors: Ebrahimi Mohsen , Nasrollahi Saeed
Published: November 2023

In this paper, using fractional mathematics, the guidance law of collision angle control is proposed by simultaneously taking into account the limitation of the seeker’s look angle. In order to apply the limitations of impact angle and launch in the equations of the acceleration command, the movement path from the time of launch to reaching the target is divided into three phases, and for each phase, a specific acceleration command is applied to the pursuer whose rules are based on optimizing and minimizing the control energy performance index with the weighting function obtained from range-to-go. The progress of the movement path and the parameters of the guidance law are compared with each other by passing three phases of the follower’s movement path with a constant speed for a fixed target in two cases of fractional and integer order.
Old detrital AFT ages from East Greenland do not require plateau erosion
Authors: Fox Matthew , Pedersen Vivi
Published: November 2023

Accurate estimates of past topography are required to reliably reconstruct past ice sheets to infer palaeoclimate. For this reason, understanding erosion rates across East Greenland is crucial to constrain landscape evolution driven by tectonics and climate-dependent erosion rates. Here we analyse published apatite fission-track (AFT) data to constrain the spatial pattern of AFT bedrock ages across the landscape. We compare these bedrock ages with published detrital distribution to highlight ambiguity in the pattern of erosion. In contrast to earlier work, we regress a simple model of exhumation pace through the bedrock ages such that age can vary as a function of both elevation and position. The resulting iso-age surfaces allow us to determine potential source areas for detrital AFT age distributions. We find that old ages observed in detrital distributions are just as likely to be sourced from low-elevation locations that are far from the coast as from high-elevation locations close to the coast. Additional data from lower temperature systems are thus required to make firm conclusions on landscape evolution in the region and distinguish between the two landscape-forming scenarios.
Building Dreams Beyond Labor: Worker Autonomy in the Age of AI
Authors: Calacci Dan
Published: November 2023

This forum focuses on the conditions and futures of the labor underpinning technology production and maintenance. We welcome standalone articles as well as interviews and conversations about all tech labor within the global supply chain of digital technologies.
--- Seyram Avle and Sarah Fox, Editors
Building Flexible, Low-Cost Wireless Access Networks with Magma
Authors: Hasan Shaddi , Padmanabhan Amar , Davie Bruce , Rexford Jennifer , Kozat Ulas , Gatewood Hunter , Sanadhya Shruti , Yurchenko Nick , Al-Khasib Tariq , Batalla Oriol , Bremner Marie , Lee Andrei , Makeev Evgeniy , Moeller Scott , Rodriguez Alex , Shelar Pravin , Subraveti Karthik , Kandi Sudarshan , Xoconostle Alejandro , Kumar Ramakrishnan Praveen , Tian Xiaochen
Published: November 2023

Good Internet connectivity has become a basic necessity all over the world. Although more than one-third of the global population does not have access to the Internet [46], commercial network operators claim that today's Internet has reached the user footprint that seems commercially viable to serve [22]. Reaching these users requires reducing the cost of providing Internet access to enable actors beyond traditional, large-scale commercial operators to build sustainable, scalable network infrastructure. Operators need effective ways to reduce costs through less expensive equipment and software and less reliance on highly skilled network administrators. At the same time, providers need ways to manage their limited network resources effectively to enable sustainable network operation - typical network policies in today's commercial networks would be "rate limit customer C to X Mbps until they have sent Y GB in interval t1, then limit to Z Mbps for interval t2."
Metabolic consequences of skeletal muscle- and liver-specific BBSome deficiency
Authors: Rouabhi Younes , Guo Deng-Fu , Zhao Yuying , Rahmouni Kamal
Published: November 2023

The ongoing epidemic of obesity and associated illnesses highlights the need to understand the biological processes that regulate energy balance. Here, we identified an important role for a protein complex called BBSome in the control of hepatic function. We show that the liver BBSome is necessary to maintain body weight and blood glucose levels due to its requirements to generate energy and detect insulin, a hormone that is essential for metabolic regulation.
Nerve excitability measured with the TROND protocol in amyotrophic lateral sclerosis: a systematic review and meta-analysis
Authors: Lugg Anna , Schindle Mason , Sivak Allison , Tankisi Hatice , Jones Kelvin E.
Published: November 2023

This meta-analysis uncovers seven potential axonal excitability biomarkers for lower motor neuron pathology in ALS, shedding light on ion channel dysfunction. The identified dysfunction aligns with the primary pathology—protein homeostasis disruption. These biomarkers could fill a gap to detect presymptomatic spread of the disease in the spinal cord and monitor treatments targeting protein homeostasis and limiting spread, toward enhancing patient care.
Central mechanisms in sympathetic nervous dysregulation in obesity
Authors: Patel Mariya , Braun Joe , Lambert Gavin , Kameneva Tatiana , Keatch Charlotte , Lambert Elisabeth
Published: November 2023

Cardiovascular and metabolic complications associated with excess adiposity are linked to chronic activation of the sympathetic nervous system, resulting in a high risk of mortality among obese individuals. Obesity-related positive energy balance underlies the progression of hypertension, end-organ damage, and insulin resistance, driven by increased sympathetic tone throughout the body. It is, therefore, important to understand the central network that drives and maintains sustained activation of the sympathetic nervous system in the obese state. Experimental and clinical studies have identified structural changes and altered dynamics in both grey and white matter regions in obesity. Aberrant activation in certain brain regions has been associated with altered reward circuitry and metabolic pathways including leptin and insulin signaling along with adiposity-driven systemic and central inflammation. The impact of these pathways on the brain via overactivity of the sympathetic nervous system has gained interest in the past decade. Primarily, the brainstem, hypothalamus, amygdala, hippocampus, and cortical structures including the insular, orbitofrontal, temporal, cingulate, and prefrontal cortices have been identified in this context. Although the central network involving these structures is much more intricate, this review highlights recent evidence identifying these regions in sympathetic overactivity in obesity.
Multisensory integration reduces landmark distortions for tactile but not visual targets
Authors: Soballa Paula , Frings Christian , Schmalbrock Philip , Merz Simon
Published: November 2023

In the present study, we directly tested the predictions of two different accounts, namely, spatial memory averaging and multisensory integration, concerning the degree of landmark distortions of targets across modalities. We showed that landmark distortions were reduced across modalities compared to distortions within modalities, which is in line with multisensory integration. Crucially, this pattern was more pronounced for tactile than for visual targets.
Investigation of the Effects of an Inferior Vena Cava Filter and Captured Clot Size on the Hemodynamic Parameters in Non-Newtonian Turbulent Pulsatile Blood Flow
Authors: Moradicheghamahi Jafar , Qasim Muhammad , Jafarpour Sohrab , Farokhi Hamed
Published: November 2023

In this computational fluid dynamics (CFD)-based study, the effects of inferior vena cava (IVC) filter implantation on the risk of IVC thrombosis have been investigated using different hemodynamic parameters, including time-averaged wall shear stress (TAWSS), the oscillating shear index (OSI), and the relative residence time (RRT). The boundary conditions in this study have been based on physiological pulses. Additionally, the k–ω model and the Carreau model have been chosen to represent the turbulent flow regime and non-Newtonian blood, respectively. For this purpose, three blood clots with the largest cross-sectional diameters of 30%, 50%, and 70% of the filter diameter have been used. Capturing a small clot in the filter has the minimum effect on the hemodynamic parameters, while by increasing the size of the captured clot, OSI and RRT parameters increase in areas downstream of the filter on the wall. The presence of a filter and clot increases the risk of thrombosis. In the case of capturing large clots, there is the possibility of damage to endothelial cells or platelet activation. Captured clots lead to the formation of plaque and thrombus on the IVC wall. However, the possibility of thrombus growth on its surface is not negligible, particularly if larger clots are trapped in the filter.
Understanding How Minerals Contribute to Optimal Immune Function
Authors: Stefanache Alina , Lungu Ionut-Iulian , Butnariu Ioan-Adrian , Calin Gabriela , Gutu Cristian , Marcu Constantin , Grierosu Carmen , Bogdan Goroftei Elena Roxana , Duceac Letitia-Doina , Dabija Marius Gabriel , Popa Florina , Damir Daniela
Published: November 2023

Sufficient mineral supply is vital not only for the innate immune system but also for the components of the adaptive immune defense, which encompass defense mechanisms against pathogens and the delicate balance of pro- and anti-inflammatory regulation in the long term. Generally, a well-balanced diet is capable of providing the necessary minerals to support the immune system. Nevertheless, specific vulnerable populations should be cautious about obtaining adequate amounts of minerals such as magnesium, zinc, copper, iron, and selenium. Inadequate levels of these minerals can temporarily impair immune competence and disrupt the long-term regulation of systemic inflammation. Therefore, comprehending the mechanisms and sources of these minerals is crucial. In exceptional circumstances, mineral deficiencies may necessitate supplementation; however, excessive intake of supplements can have adverse effects on the immune system and should be avoided. Consequently, any supplementation should be approved by medical professionals and administered in recommended doses. This review emphasizes the crucial significance of minerals in promoting optimal functioning of the immune system. It investigates the indispensable minerals required for immune system function and the regulation of inflammation. Moreover, it delves into the significance of maintaining an optimized intake of minerals from a nutritional standpoint.
Carbon Emission Performance of Robot Application: Influencing Mechanisms and Heterogeneity Characteristics
Authors: Zhang Luguang , Shen Qitaisong
Published: November 2023

With the new round of technological revolution and industrial change, industrial robots have an important role to play in the fight against climate change and in achieving the goal of “carbon peaking and carbon neutrality.” Based on the panel data of the application level of industrial robots in Shanghai and Shenzhen A-share listed companies from 2011 to 2019, this study examines the impact of industrial robots on carbon emission performance and discusses specific ways industrial robots can affect carbon emission performance. The results show that industrial robots can significantly improve carbon emission performance. Mechanism analysis shows that industrial robots can improve carbon emission performance through productivity and competition effects. Heterogeneity analysis shows that the application effect of industrial robots varies based on enterprise nature, regional location, and carbon emission intensity. The study can make potential contributions. First, this study systematically analyzes the impact of artificial intelligence technology on carbon emissions from the perspective of carbon emission performance, which can supplement the research on carbon emission performance. Second, this study calculates application levels of artificial intelligence technology at the enterprise level and uses panel and linear intermediary effect models to analyze the transmission mechanism between the application of artificial intelligence technology and carbon emission performance. Third, the heterogeneity analysis results can provide empirical support for formulating differentiated artificial intelligence carbon reduction strategies and be used as a reference to further promote the green development of artificial intelligence technology.
Enhancing Zinc Uptake through Dual-Modification of Cicer arietinum Protein
Authors: Patil Nikhil Dnyaneshwar , Bains Aarti , Sridhar Kandi , Kaur Sawinder , Ali Nemat , AlAsmari Abdullah F. , Patil Sandip , Chawla Prince , Sharma Minaxi
Published: November 2023

Zinc is crucial for physiological processes; however, deficiency persists globally. Binding zinc to plant proteins enhances absorption, minimizing toxicity risks and offering a potential solution for deficiency. Mineral binding efficiency of the unmodified protein is limited; hence, dual modification (succinylation and ultrasonication) is potentially used to achieve higher binding efficiency. Enhancing zinc uptake is crucial for cellular health due to its vital roles in various biological processes including enzymatic activity, DNA repair, immune function, antioxidant defense, hormone regulation, brain function, signaling, growth, gene expression, and reproduction. Therefore, this research aimed to develop a chickpea protein-zinc complex and to evaluate the influence of dual modification on their physiochemical, bioavailability, and cellular mineral uptake attributes. Succinylation exhibited significant improvements in the water-holding capacity by 28.73%, oil-holding capacity by 34.09%, and solubility by 5.46% of the chickpea protein-zinc complex as compared to the native complex. Mineral bioavailability increased by 8.32%, and there were notable increases in cellular uptake of zinc by 2.10%, retention by 5.80%, and transport by 3.96%, respectively. Furthermore, the dual modification approach resulted in a notable decrease in the particle size of the chickpea protein-zinc complex, with a substantial reduction of 73.25% and an increased zeta potential value of −21 mV compared to the succinylated complex. As well, dual modification concurrently led to a substantial decline of 48.04% in the sulfhydryl (SH) content, coupled with a marked increase of 21.92% in the surface hydrophobicity. In addition, zinc bioavailability, cellular uptake, retention, and transport were further enhanced by 1.89, 3.34, and 4.8% through dual modification. Our findings highlight that the dual modification of the chickpea protein-zinc complex shows a promising strategy for enhancing the techno-functional characteristics, bioavailability, and cellular uptake of zinc, which could be a better platform for developing vegan foods.
Central Retinal Vein Occlusion with Three-Retinal Quadrant Involvement: Another Focus on Optic Disc Head Vascular Anatomy Variations
Authors: Hassanpoor Narges , Abdolrahimi Vahid , Niyousha Mohamad Reza
Published: November 2023

A 50-year-old male patient with sudden visual acuity loss in his right eye came to our clinic. Visual acuity at presentation was 1/10 in right eye and 10/10 in left. The patient was otherwise healthy Caucasian man without any history of previous systemic or ophthalmic disease. There was not any history of amblyopia and refractive error. Anterior segment findings were unremarkable. Three quadrants of retina were fully involved with central retinal vein occlusion (CRVO) features including retinal hemorrhages, retinal edema obscuring retinal details, and cotton wool spots while sparing inferior temporal quadrant. Inferior temporal quadrant sparing in this patient is due to a specific retinal vascular anatomical variation. In conclusion, in unusual presentations of retinal vascular branch obstructions, considering retinal vascular anatomy variations would help us to explain the clinical presentation more precisely in some cases.
Supplementary Data from Fasting-Mimicking Diet Drives Antitumor Immunity against Colorectal Cancer by Reducing IgA-Producing Cells
Authors: Zhong Ziwen , Zhang Hao , Nan Ke , Zhong Jing , Wu Qichao , Lu Lihong , Yue Ying , Zhang Zhenyu , Guo Miaomiao , Wang Zhiqiang , Xia Jie , Xing Yun , Fu Ying , Yu Baichao , Zhou Wenchang , Sun Xingfeng , Shen Yang , Chen Wankun , Zhang Jie , Zhang Jin , Ma Duan , Chu Yiwei , Liu Ronghua , Miao Changhong
Published: November 2023

Supplemental materials and methods
Figure S7 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases
Authors: Zheng Yannan , Zhou Rui , Cai Jianan , Yang Nanyan , Wen Zhaowei , Zhang Zhihua , Sun Huiying , Huang Genjie , Guan Yijin , Huang Na , Shi Min , Liao Yulin , Bin Jianping , Liao Wangjun
Published: November 2023

Figure. S7 Matrix stiffness induces lipolysis in HSCs via activating the FAK-YAP signaling pathway.
Figure S2 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases
Authors: Zheng Yannan , Zhou Rui , Cai Jianan , Yang Nanyan , Wen Zhaowei , Zhang Zhihua , Sun Huiying , Huang Genjie , Guan Yijin , Huang Na , Shi Min , Liao Yulin , Bin Jianping , Liao Wangjun
Published: November 2023

Figure.S2 HSCs are essential for matrix stiffness-mediated FAO metabolic reprogramming in colon cancer cells.
Figure S6 from Cross-talk between Myeloid and B Cells Shapes the Distinct Microenvironments of Primary and Secondary Liver Cancer
Authors: Chen Zhihang , Zhang Guopei , Ren Xiaoxue , Yao Zhijia , Zhou Qian , Ren Xuxin , Chen Shuling , Xu Lixia , Sun Kaiyu , Zeng Qianwen , Kuang Ming , Kuang Dong-Ming , Peng Sui
Published: November 2023

Figure S6
Data from The IGF2BP3–COPS7B Axis Facilitates mRNA Translation to Drive Colorectal Cancer Progression
Authors: Tang Jing , Wang Shuoshuo , Weng Mingjiao , Guo Qingyu , Ren Lili , He Yan , Cui Zihan , Cong Mingqi , Qin Minglu , Yu Jia , Su Rui , Li Xiaobo
Published: November 2023

Abstract
Many studies have provided valuable information about genomic and transcriptomic changes that occur in colorectal cancer. However, protein abundance cannot be reliably predicted by DNA alteration or mRNA expression, which can be partially attributed to posttranscriptional and/or translational regulation of gene expression. In this study, we identified increased translational efficiency (TE) as a hallmark of colorectal cancer by evaluating the transcriptomic and proteomic features of patients with colorectal cancer, along with comparative transcriptomic and ribosome-protected mRNA analysis in colon epithelial cells and colon cancer cells. COP9 signalosome subunit 7B (COPS7B) was among the key genes that consistently showed both significant TE increase and protein elevation without transcriptional alteration in colorectal cancer. Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) enhanced the TE of COPS7B mRNA to promote colorectal cancer growth and metastasis. COPS7B was found to be a component of the ribo-interactome that interacted with ribosomes to facilitate ribosome biogenesis and mRNA translation initiation. Collectively, this study revealed the proteomic features of colorectal cancer and highlighted elevated mRNA translation as a hallmark of colorectal cancer. The identification of the IGF2BP3–COPS7B axis underlying the increased protein synthesis rate in colorectal cancer provided a promising therapeutic target to treat this aggressive disease.
Significance:
Increased expression of COPS7B mediated by IGF2BP3 elevates the translational efficiency of genes enriched in mRNA translation and ribosome biogenesis pathways, promoting protein synthesis and driving progression in colorectal cancer.
Data from Crosstalk between myeloid and B cells shapes the distinct microenvironments of primary and secondary liver cancer
Authors: Chen Zhihang , Zhang Guopei , Ren Xiaoxue , Yao Zhijia , Zhou Qian , Ren Xuxin , Chen Shuling , Xu Lixia , Sun Kaiyu , Zeng Qianwen , Kuang Ming , Kuang Dong-Ming , Peng Sui
Published: November 2023

Abstract
The tumor microenvironment is distinctive in primary and secondary liver cancer. B cells represent an important component of immune infiltrates. Here, we demonstrated that B cells are an important regulator in hepatocellular carcinoma (HCC) and colorectal cancer liver metastasis (CRLM) microenvironments. B cells displayed distinct developmental trajectories in HCC and CRLM. Single-cell analysis revealed that IgG+ plasma cells preferentially accumulated in HCC while IgA+ plasma cells were preferentially enriched in CRLM. Mechanistically, IgG+ plasma cells in HCC were recruited by tumor-associated macrophages via the CXCR3-CXCL10 axis, whereas IgA+ plasma cells in CRLM were recruited by metastatic tumor cells via CCR10-CCL28 signaling. Functionally, IgG+ plasma cells preferentially promoted pro-tumorigenic macrophages formation in HCC, and IgA+ plasma cells preferentially induced granulocytic myeloid-derived suppressor cells activation in CRLM. Clinically, increased infiltration of IgG+ plasma cells and macrophages in HCC was correlated to worse survival, while increased intratumoral IgA+ plasma cells and neutrophils in CRLM indicated poor prognosis. Taken together, this study demonstrated plasma and myeloid cell-mediated immunosuppression in HCC and CRLM, suggesting that selectively modulating primary or secondary tumor-related immunosuppressive regulatory networks might reprogram the microenvironment and provide an immunotherapeutic strategy for treating liver cancer.
Data from Cross-talk between Myeloid and B Cells Shapes the Distinct Microenvironments of Primary and Secondary Liver Cancer
Authors: Chen Zhihang , Zhang Guopei , Ren Xiaoxue , Yao Zhijia , Zhou Qian , Ren Xuxin , Chen Shuling , Xu Lixia , Sun Kaiyu , Zeng Qianwen , Kuang Ming , Kuang Dong-Ming , Peng Sui
Published: November 2023

Abstract
The tumor microenvironment is distinctive in primary and secondary liver cancer. B cells represent an important component of immune infiltrates. Here, we demonstrated that B cells are an important regulator in hepatocellular carcinoma (HCC) and colorectal cancer liver metastasis (CRLM) microenvironments. B cells displayed distinct developmental trajectories in HCC and CRLM. Single-cell analysis revealed that IgG+ plasma cells preferentially accumulated in HCC, whereas IgA+ plasma cells were preferentially enriched in CRLM. Mechanistically, IgG+ plasma cells in HCC were recruited by tumor-associated macrophages via the CXCR3–CXCL10 axis, whereas IgA+ plasma cells in CRLM were recruited by metastatic tumor cells via CCR10–CCL28 signaling. Functionally, IgG+ plasma cells preferentially promoted protumorigenic macrophages formation in HCC, and IgA+ plasma cells preferentially induced granulocytic myeloid-derived suppressor cells activation in CRLM. Clinically, increased infiltration of IgG+ plasma cells and macrophages in HCC was correlated to worse survival, whereas increased intratumoral IgA+ plasma cells and neutrophils in CRLM indicated poor prognosis. Taken together, this study demonstrated plasma and myeloid cell-mediated immunosuppression in HCC and CRLM, suggesting that selectively modulating primary or secondary tumor-related immunosuppressive regulatory networks might reprogram the microenvironment and provide an immunotherapeutic strategy for treating liver cancer.
Significance:
The immunomodulatory patterns of tumor-infiltrating B cells are distinct in primary and secondary liver cancer, with plasma cells mediating important physiologic processes that drive cancer progression.
Molecular Mechanism of Fasting-Mimicking Diet in Inhibiting Colorectal Cancer Progression: Implications for Immune Therapy and Metabolic Regulation
Authors: Bush Clancy O. , Perry Rachel J.
Published: November 2023

Recently, fasting-mimicking diet and caloric restriction have been shown to improve antitumor immunity. In this issue of Cancer Research, Zhong and colleagues provide insights into the molecular mechanism of fasting-mimicking diet–mediated metabolic reprogramming in colorectal cancer progression. The authors performed comprehensive mechanistic experiments in mouse models to show that fasting-mimicking diet prevents colorectal cancer progression by lowering intratumoral IgA+ B cells by accelerating fatty acid oxidation to inhibit B-cell IgA class switching. In addition, they found that fatty acid oxidation–dependent acetylation prevents IgA class switching and that IgA+ B cells interfere with the anticancer effects of fasting-mimicking diet in colorectal cancer. Overall, their study establishes that fasting-mimicking diet has the potential to activate anticancer immunity and to induce tumor regression in colorectal cancer.

See related article by Zhong et al., p. 3529
Supplementary Table S2 from Assessing a Polygenic Risk Score for Lung Cancer Susceptibility in Non-Hispanic White and Black Populations
Authors: Trendowski Matthew R. , Lusk Christine M. , Wenzlaff Angela S. , Neslund-Dudas Christine , Gadgeel Shirish M. , Soubani Ayman O. , Schwartz Ann G.
Published: November 2023

This supplementary table provides the statistical association between SNPs included in the PRS and lung cancer status.
Supplementary Figure 3 from Sources of Disparities in Surveillance Mammography Performance and Risk-Guided Recommendations for Supplemental Breast Imaging: A Simulation Study
Authors: Hubbard Rebecca A. , Pujol Toyya A. , Alhajjar Elie , Edoh Kossi , Martin Melissa L.
Published: November 2023

Supplementary Figure 3. Simulation results for surveillance mammography positive predictive value overall and stratified by race and ethnicity in simulated populations of women with a personal history of breast cancer
Data from Sources of Disparities in Surveillance Mammography Performance and Risk-Guided Recommendations for Supplemental Breast Imaging: A Simulation Study
Authors: Hubbard Rebecca A. , Pujol Toyya A. , Alhajjar Elie , Edoh Kossi , Martin Melissa L.
Published: November 2023

AbstractBackground:
Surveillance mammography is recommended for all women with a history of breast cancer. Risk-guided surveillance incorporating advanced imaging modalities based on individual risk of a second cancer could improve cancer detection. However, personalized surveillance may also amplify disparities.
Methods:
In simulated populations using inputs from the Breast Cancer Surveillance Consortium (BCSC), we investigated race- and ethnicity-based disparities. Disparities were decomposed into those due to primary breast cancer and treatment characteristics, social determinants of health (SDOH) and differential error in second cancer ascertainment by modeling populations with or without variation across race and ethnicity in the distribution of these characteristics. We estimated effects of disparities on mammography performance and supplemental imaging recommendations stratified by race and ethnicity.
Results:
In simulated cohorts based on 65,446 BCSC surveillance mammograms, when only cancer characteristics varied by race and ethnicity, mammograms for Black women had lower sensitivity compared with the overall population (64.1% vs. 71.1%). Differences between Black women and the overall population were larger when both cancer characteristics and SDOH varied by race and ethnicity (53.8% vs. 71.1%). Basing supplemental imaging recommendations on high predicted second cancer risk resulted in less frequent recommendations for Hispanic (6.7%) and Asian/Pacific Islander women (6.4%) compared with the overall population (10.0%).
Conclusions:
Variation in cancer characteristics and SDOH led to disparities in surveillance mammography performance and recommendations for supplemental imaging.
Impact:
Risk-guided surveillance imaging may exacerbate disparities. Decision-makers should consider implications for equity in cancer outcomes resulting from implementing risk-guided screening programs.

See related In the Spotlight, p. 1479
Data from Prediagnostic Hormone Levels and Risk of Testicular Germ Cell Tumors: A Nested Case–Control Study in the Janus Serum Bank
Authors: Wu Zeni , Trabert Britton , Guillemette Chantal , Caron Patrick , Bradwin Gary , Graubard Barry I. , Weiderpass Elisabete , Ursin Giske , Langseth Hilde , McGlynn Katherine A.
Published: November 2023

AbstractBackground:
It has been hypothesized that poorly functioning Leydig and/or Sertoli cells of the testes, indicated by higher levels of serum gonadotropins and lower levels of androgens, are related to the development of testicular germ cell tumors (TGCT). To investigate this hypothesis, we conducted a nested case–control study within the Janus Serum Bank cohort.
Methods:
Men who developed TGCT (n = 182) were matched to men who did not (n = 364). Sex steroid hormones were measured using LC/MS. Sex hormone binding globulin, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were quantified by direct immunoassay. Multivariable logistic regression was used to calculate ORs and 95% confidence intervals (CI) for associations between hormone levels and TGCT risk.
Results:
Higher FSH levels [tertile (T) 3 vs. T2: OR = 2.89, 95% CI = 1.83–4.57] were associated with TGCT risk, but higher LH levels were not (OR = 1.26, 95% CI = 0.81–1.96). The only sex steroid hormone associated with risk was androstane-3α, 17β-diol-3G (3α-diol-3G; OR = 2.37, 95% CI = 1.46–3.83). Analysis by histology found that increased FSH levels were related to seminoma (OR = 3.55, 95% CI = 2.12–5.95) but not nonseminoma (OR = 1.19, 95% CI = 0.38–3.13). Increased levels of 3α-diol-3G were related to seminoma (OR = 2.29, 95% CI = 1.35–3.89) and nonsignificantly related to nonseminoma (OR = 2.71, 95% CI = 0.82–8.92).
Conclusions:
Higher FSH levels are consistent with the hypothesis that poorly functioning Sertoli cells are related to the development of TGCT. In contrast, higher levels of 3α-diol-3G do not support the hypothesis that insufficient androgenicity is related to risk of TGCT.
Impact:
Clarifying the role of sex hormones in the development of TGCT may stimulate new research hypotheses.
Advancing Social and Environmental Research in Cancer Registries Using Geomasking for Address-Level Data
Authors: Iyer Hari S. , Shi Xun , Satagopan Jaya M. , Cheng Iona , Roscoe Charlotte , McLaughlin Robert H. , Stroup Antoinette M. , Setoguchi Soko , Bandera Elisa V. , Hernandez Brenda Y. , Doherty Jennifer A. , Hsieh Mei-Chin , Knowlton Richard , Qin Bo , Laden Francine , Rebbeck Timothy R. , Gomez Scarlett L.
Published: November 2023

Understanding the social and environmental causes of cancer in the United States, particularly in marginalized communities, is a major research priority. Population-based cancer registries are essential for advancing this research, given their nearly complete capture of incident cases within their catchment areas. Most registries limit the release of address-level geocodes linked to cancer outcomes to comply with state health departmental regulations. These policies ensure patient privacy, uphold data confidentiality, and enhance trust in research. However, these restrictions also limit the conduct of high-quality epidemiologic studies on social and environmental factors that may contribute to cancer burden. Geomasking refers to computational algorithms that distort locational data to attain a balance between effectively “masking” the original address location while faithfully maintaining the spatial structure in the data. We propose that the systematic deployment of scalable geomasking algorithms could accelerate research on social and environmental contributions across the cancer continuum by reducing measurement error bias while also protecting privacy. We encourage multidisciplinary teams of registry officials, geospatial analysts, cancer researchers, and others engaged in this form of research to evaluate and apply geomasking procedures based on feasibility of implementation, accuracy, and privacy protection to accelerate population-based research on social and environmental causes of cancer.
Supplemental Figure S6 from Inhibition of NAD+-Dependent Metabolic Processes Induces Cellular Necrosis and Tumor Regression in Rhabdomyosarcoma Models
Authors: McKay-Corkum Grace B. , Collins Victor J. , Yeung Choh , Ito Takeshi , Issaq Sameer H. , Holland David , Vulikh Ksenia , Zhang Yiping , Lee Unsun , Lei Haiyan , Mendoza Arnulfo , Shern Jack F. , Yohe Marielle E. , Yamamoto Kazutoshi , Wilson Kelli , Ji Jiuping , Karim Baktiar O. , Thomas Craig J. , Krishna Murali C. , Neckers Leonard M. , Heske Christine M.
Published: November 2023

Supplemental Figure S6: Gene set enrichment analysis (GSEA) comparing RMS cell lines that undergo a non-necrotic response to OT-82 versus a necrotic response to OT-82
Supplementary Data S8 from Genomic Profiling of Metastatic Castration-Resistant Prostate Cancer Samples Resistant to Androgen Receptor Pathway Inhibitors
Authors: Menssouri Naoual , Poiraudeau Loïc , Helissey Carole , Bigot Ludovic , Sabio Jonathan , Ibrahim Tony , Pobel Cédric , Nicotra Claudio , Ngo-Camus Maud , Lacroix Ludovic , Rouleau Etienne , Tselikas Lambros , Chauchereau Anne , Blanc-Durand Félix , Bernard-Tessier Alice , Patrikidou Anna , Naoun Natacha , Flippot Ronan , Colomba Emeline , Fuerea Alina , Albiges Laurence , Lavaud Pernelle , van de Wiel Paul , den Biezen Eveline , Wesseling-Rozendaal Yvonne , Ponce Santiago , Michiels Stefan , Massard Christophe , Gautheret Daniel , Barlesi Fabrice , André Fabrice , Besse Benjamin , Scoazec Jean-Yves , Friboulet Luc , Fizazi Karim , Loriot Yohann
Published: November 2023

Supplementary Data 8 describes GSEA analysis with overexpressed and underexpressed gene sets in primary resistant samples.
Supplementary Data S4 from Genomic Profiling of Metastatic Castration-Resistant Prostate Cancer Samples Resistant to Androgen Receptor Pathway Inhibitors
Authors: Menssouri Naoual , Poiraudeau Loïc , Helissey Carole , Bigot Ludovic , Sabio Jonathan , Ibrahim Tony , Pobel Cédric , Nicotra Claudio , Ngo-Camus Maud , Lacroix Ludovic , Rouleau Etienne , Tselikas Lambros , Chauchereau Anne , Blanc-Durand Félix , Bernard-Tessier Alice , Patrikidou Anna , Naoun Natacha , Flippot Ronan , Colomba Emeline , Fuerea Alina , Albiges Laurence , Lavaud Pernelle , van de Wiel Paul , den Biezen Eveline , Wesseling-Rozendaal Yvonne , Ponce Santiago , Michiels Stefan , Massard Christophe , Gautheret Daniel , Barlesi Fabrice , André Fabrice , Besse Benjamin , Scoazec Jean-Yves , Friboulet Luc , Fizazi Karim , Loriot Yohann
Published: November 2023

Supplementary Data 4 describes the results of mutational signatures of the whole cohort.
Supplementary Data S14 from Genomic Profiling of Metastatic Castration-Resistant Prostate Cancer Samples Resistant to Androgen Receptor Pathway Inhibitors
Authors: Menssouri Naoual , Poiraudeau Loïc , Helissey Carole , Bigot Ludovic , Sabio Jonathan , Ibrahim Tony , Pobel Cédric , Nicotra Claudio , Ngo-Camus Maud , Lacroix Ludovic , Rouleau Etienne , Tselikas Lambros , Chauchereau Anne , Blanc-Durand Félix , Bernard-Tessier Alice , Patrikidou Anna , Naoun Natacha , Flippot Ronan , Colomba Emeline , Fuerea Alina , Albiges Laurence , Lavaud Pernelle , van de Wiel Paul , den Biezen Eveline , Wesseling-Rozendaal Yvonne , Ponce Santiago , Michiels Stefan , Massard Christophe , Gautheret Daniel , Barlesi Fabrice , André Fabrice , Besse Benjamin , Scoazec Jean-Yves , Friboulet Luc , Fizazi Karim , Loriot Yohann
Published: November 2023

Supplementary data 14 describes the GSEA analysis of resistant samples vs baseline samples from patients with acquired resistance and without neuroendocrine feature
Supplementary Tables S1-S3 from MGMT Promoter Methylation Predicts Overall Survival after Chemotherapy for 1p/19q-Codeleted Gliomas
Authors: Kinslow Connor J. , Rae Ali I. , Taparra Kekoa , Kumar Prashanth , Siegelin Markus D. , Grinband Jack , Gill Brian J.A. , McKhann Guy M. , Sisti Michael B. , Bruce Jeffrey N. , Canoll Peter D. , Iwamoto Fabio M. , Horowitz David P. , Kachnic Lisa A. , Neugut Alfred I. , Yu James B. , Cheng Simon K. , Wang Tony J.C.
Published: November 2023

Tables S1-S3
Supplementary Table S4 from Exercise Training Reduces the Inflammatory Response and Promotes Intestinal Mucosa-Associated Immunity in Lynch Syndrome
Authors: Deng Nan , Reyes-Uribe Laura , Fahrmann Johannes F. , Thoman Whittney S. , Munsell Mark F. , Dennison Jennifer B. , Murage Eunice , Wu Ranran , Hawk Ernest T. , Thirumurthi Selvi , Lynch Patrick M. , Dieli-Conwright Christina M. , Lazar Alexander J. , Jindal Sonali , Chu Khoi , Chelvanambi Manoj , Basen-Engquist Karen , Li Yisheng , Wargo Jennifer A. , McAllister Florencia , Allison James P. , Sharma Padmanee , Sinha Krishna M. , Hanash Samir , Gilchrist Susan C. , Vilar Eduardo
Published: November 2023

Table S4. Untargeted metabolomic analyses in the serum metabolome.
Supplementary Figure S1 from Dissecting the Mechanisms Underlying the Cytokine Release Syndrome (CRS) Mediated by T-Cell Bispecific Antibodies
Authors: Leclercq-Cohen Gabrielle , Steinhoff Nathalie , Albertí Servera Llucia , Nassiri Sina , Danilin Sabrina , Piccione Emily , Yángüez Emilio , Hüsser Tamara , Herter Sylvia , Schmeing Stephan , Gerber Petra , Schwalie Petra , Sam Johannes , Briner Stefanie , Jenni Sylvia , Bianchi Roberta , Biehl Marlene , Cremasco Floriana , Apostolopoulou Katerina , Haegel Hélène , Klein Christian , Umaña Pablo , Bacac Marina
Published: November 2023

Supplementary Figure S1. Levels of cytokines were measured by Luminex in serum from whole blood assay with CD20-TCB. 1 donor.
Supplementary Figure S7 from Clinical and Molecular Features of Long-term Response to Immune Checkpoint Inhibitors in Patients with Advanced Non–Small Cell Lung Cancer
Authors: Thummalapalli Rohit , Ricciuti Biagio , Bandlamudi Chaitanya , Muldoon Daniel , Rizvi Hira , Elkrief Arielle , Luo Jia , Alessi Joao V. , Pecci Federica , Lamberti Giuseppe , Di Federico Alessandro , Hong Lingzhi , Zhang Jianjun , Heymach John V. , Gibbons Don L. , Plodkowski Andrew J. , Ravichandran Vignesh , Donoghue Mark T.A. , Vanderbilt Chad , Ladanyi Marc , Rudin Charles M. , Kris Mark G. , Riely Gregory J. , Chaft Jamie E. , Hellmann Matthew D. , Vokes Natalie I. , Awad Mark M. , Schoenfeld Adam J.
Published: November 2023

Univariable and multivariable analyses of association of clinical characteristics with patients achieving complete response (CR) compared to patients not achieving complete response (non-CR).