bluuebunny/crossref_metadata_2025 huggingface dataset:
PROBLEMATIC ISSUES OF LIMB AMPUTATION IN WOUNDED WITH COMBAT TRAUMA
Authors: Trutyak Ihor , Malickii Vasyl , Samotowka Michael , Trunkvalter Vasyl , Trutyak Roman , Ivaschenko Vitalij
Published: December 2023

Among the wounded with limb injuries admitted to the Military Medical Center of the Western region during the year of Russia’s full-scale war in Ukraine, 29% had a mine-blast injury, 47% had shrapnel wounds, 8% had gunshot bullet wounds, 1.5% – thermal injuries, and14.5% – traumatic injuries. Upper limbs were injured in 22%, lower – in 32%, 15% had two limbs injured, and 31% had combined combat trauma. In all hospitalized with multi-fragment fractures, limbs were fixed with external fixation devices. 2% of patients had vascular damage. All wounded had unhealed wounds with a soft tissue defect. The average age of patients was 30 years. There were no comorbid diseases in the wounded, and concomitant diseases that did not affect the course of injury were found in 10%. Amputations of limbs were performed in 6.5%. Traumatic separation of a limb segment or its destruction with crushed bone and non-viable soft tissues, nerve damage with significant defect, soft tissue and bone defect, as well as thermal ischemia of the limb for more than 6 hours with necrosis of its soft tissues, were indications for primary limb amputation in 3% of wounded and injured, which were in the nature of primary debridement. Progressive wound infection with the development of the septic condition of the wounded despite intensive treatment, total ischemic necrosis, and recrudescent arrosive bleeding from great vessels required a secondary limb amputation in 1.5%. In 1.5% of the wounded, staged operations were performed as re-amputations. Re-amputation had to be performed in 0.6% of patients with an inappropriate limb stump level, which complicated prosthetics. To reduce the number of amputations for secondary indications, a timely diagnosis is needed of compartment syndrome and rational treatment of soft tissue wounds and gunshot fractures with surgical and medical prevention of the infectious process.
THE STUDY OF ASSOCIATIONS BETWEEN IL1Β C3953T GENE POLYMORPHISM AND CLINICAL-NEUROLOGICAL, NEUROIMAGING, HEMODYNAMIC CHARACTERISTICS AND COGNITIVE DYSFUNCTION IN PATIENTS WITH POST-INFECTIOUS ENCEPHALOPATHY
Authors: Duve Khrystyna , Olszewski Robert , Shkrobot Svitlana , Shalabay Natalia
Published: December 2023

The aim: To investigate potential associations between the C3953T polymorphic variant of the interleukin-one beta (IL1β) gene and clinical-neurological, neuroimaging, hemodynamic characteristics, as well as cognitive dysfunction in patients with post-infectious encephalopathy (PIE).

Materials and methods: A total of 128 patients with post-infectious encephalopathy (PIE) who were receiving inpatient treatment in the neurological departments of the Communal Non-commercial Enterprise “Ternopil Regional Clinical Psychoneurological Hospital” of Ternopil Regional Council,” Ternopil, Ukraine, were examined and included in the retrospective analysis in 2021–2022. The molecular-genetic testing was performed for 26 patients in the molecular genetics laboratory of the State Institution “Reference Centre for Molecular Diagnostics of the Ministry of Health of Ukraine,” Kyiv. The control group consisted of 12 people, who were representative in age and gender. Statistical processing of the results was performed using the STATISTICA 10.0 software.

Results: Analysis of the dependence of neuroimaging changes on the frequency of genotypes of the C3953T polymorphic variant of the IL1β gene in patients with PIE showed a significant relationship between their frequency distribution and the presence/absence of gliosis phenomena (p=0.009). Thus, gliosis was detected in all carriers of the T/T genotype C3953T polymorphic variant of the IL1β gene. Analyzing the dependence of changes obtained during the transcranial Doppler ultrasound scanning of cerebral vessels on the polymorphic variant C3953T of the IL1β gene in patients with PIE, all carriers of the T/T genotype were diagnosed with angiospasm (p=0.038) and vertebrobasilar insufficiency (p=0.010).

Conclusions: Results suggest the reasonability of further researching the interaction between IL1β and glial cells and changes in the cognitive functioning of cytokine genotypes with larger sample sizes that may help explain the pathophysiological mechanisms leading to cognitive impairment in patients with PIE.
THE INFLUENCE OF VESSEL CURVATURE AND THROMBUS COMPOSITION ON THE EFFECTIVENESS AND OUTCOMES OF THROMBECTOMY IN THE CASE OF ACUTE ISCHEMIC STROKE
Authors: Lylyk Pedro , Netliukh Andrii , Kobyletskyi Oleh , Holub Oleksander , Sukhanov Andrian
Published: December 2023

Introduction. It is believed that vascular anatomy has a direct influence on the complexity and course of mechanical thrombectomy, and its outcome determines the degree of reperfusion and clinical effect.

Aim. To analyze the influence of the curvature of the intracranial arteries and the composition of the thrombus on the results of thrombectomy.

Materials and methods. 64 patients who underwent mechanical thrombectomy for acute proximal occlusion of the ICA or MCA were prospectively examined. (44man/20women among them, the age of the patients ranged from 47-89years (67.2±1.2). The study was performed by measuring the ICA-M1 angle on angiograms in direct projection. Angles were compared between patients with successful (mTICI group 2b/3) and unsuccessful (mTICI group 0-2a) reperfusion. The functional result was evaluated according to the mRS scale as positive (0-3) and negative (4-5). Removed thrombi were examined by light microscopy with hematoxylin-eosin and orange-red-blue staining.

Results. Among patients of the mTICI 2b/3 group, a larger angle of the ICA-M1 was measured (126.4±2.8°) compared to patients in the mTICI 0-2a group - 107.1±4.9° (p=0.05). Among patients with 1-2 passages, statistically significantly larger ICA-M1 angles were recorded (129.8±3.3°) than among patients with a number of passages >2 (109.2±5,7°, p<0.02). The duration of mechanical thrombectomy was <60min among patients with larger angles of the ICA-M1 (127.6±4.4° vs. 119.6±4.5°) than in patients with long interventions (>60 min) (p<0.05). Successful reperfusion (group mTICI 2b/3) was achieved in 47 (73.4%) patients. A clinically positive result(mRS 0-3) was observed among 37(57.8%) patients.

During microscopic examination of thrombi among patient groups mTICI 0/2a, fibrin threads with signs of aging with purple and blue color were present on the periphery (24-48hours). With a favorable outcome of the operation, the coagulated fibrin fibers were stained red (<16hours).

Conclusions. With a smaller curvature of the ICA and its branches, and in the presence of "fresh" thrombi, the efficiency of operations increases, and the number of passages and the duration of mechanical thrombectomy decrease. The neurological status of patients at admission correlates with the functional outcome at the time of discharge.
GUT MICROBIOME IN ACUTE CORONARY SYNDROME
Authors: Yusko Lesya , Chendey Taras , Lohoida Vasyl , Meleshko Tamara , Rishko Mykola , Konic-Ristic Aleksandra , Boyko Nadiya
Published: December 2023

Introduction: The intestinal microbiome is a diagnostic indicator and therapeutic target for non-communicable diseases. The aim of this work is to test the relationship between arterial stiffness, elasticity, gut microbiota and inflammation markers in the patients with acute coronary syndrome.

Methods: Elastic properties of arteries were evaluated by non-invasive arteriography (Tensiomed, Hungary), and intestinal microbiota was studied with the determination of key representatives by routine culturing methodology using biochemical identification kits (LACHEMA, Czech Republic). The level of SIgA and cytokines were detected by enzyme-linked immunosorbent assay (ELISA). The data obtained for the clinical experimental group of patients were compared with the results obtained for the control group.

Results: Obtained data demonstrated a strong correlation between intestinal colonization by Enterococcus faecalis and PPbr (r=0.98), AIbr (r=-0.99) and AIao (r=-0.99). Significant correlations were found for Escherichia coli (lac+) and PPbr indicators (r=-0.97), and for Klebsiella oxytoca and SBP (r=-0.95), the systolic area index of the volumetric curve (r=+0.99), and the index of the diastolic area of the volumetric curve (r=-0.99). Indexed areas of the volumetric curve were correlated with colonization of Streptococcus spp. (r=-0.9 and 0.9 for systolic and diastolic area, respectively). Blood pressure correlated with the consentration of Candida spp. (r=0.95).

Conclusion: Detected bacteria (E. faecalis, K. oxytoca), pro-inflammatory cytokines, and intestine level of SIgA correlated with increased arterial stiffness and elasticity observed in patients with acute coronary syndromes (ACS) might be used as a rationale for the prevention and individual treatment of ACS in the earlier stages of the disease.
CLINICAL RESULTS OF INFERTILITY TREATMENT IN PATIENTS WITH A COMORBIDITY OF UTERINE LEIOMYOMA AND CHRONIC ENDOMETRITIS WITH OPTIMIZATION OF CRYOPTOCOLS FOR EMBRYO TRANSFER PREPARATION
Authors: Khmil Mariya , Petryshyn Natalya , Pravak Yuliia , Halnykina Svitlana , Khmil Mariya , Khmil Doswald Anna , Romanchuk Lesia , Szlachcic Mirosław
Published: December 2023

Infertility is a major medical and social issue. In vitro fertilization is an advanced ART technique that helps to successfully cure infertility. Quality preparation for an IVF protocol and the subsequent pregnancy is important and should include treatment of concomitant pathology, evaluation of the condition of the uterine cavity and its optimal preparation in order to prevent reproductive failures and early obstetric losses. This study assessed the effectiveness of optimized cryoprotocols for preparation for embryo transfer in patients with infertility and the comorbid course of uterine leiomyoma and chronic endometritis. We performed clinical examination and comparative analysis of anamnestic data of 100 women with infertility and comorbid uterine leiomyoma and chronic endometritis. The patients were divided into two groups depending on the proposed treatment scheme and the outcomes were compared to a control group. In all groups, stimulation of superovulation was carried out following a short protocol with a GnRH antagonist. We determined that patients with infertility comorbid with uterine leiomyoma and chronic endometritis, when compared to the control group patients, had a history of early menarche, early onset of sexual life, a greater number of sexual partners, a greater incidence of urogenital infections, and of performed intrauterine surgical procedures. The patients in the modified treatment group received a lower mean total dose of gonadotropins, had a shorter duration of stimulation, and fewer days of anti-GnRH administration compared to the traditional treatment group. The patients in the modified treatment group also had a higher frequency of clinical pregnancy and delivery compared to those received conventional treatment. An appropriate anti-inflammatory and antibiotic therapy and comprehensive preparation of the uterine cavity for embryo transfer are key factors in the success of IVF protocols.
HYPOPLASTIC LEFT HEART SYNDROME AND COMPLETE CONGENITAL HEART BLOCK IN A NEWBORN, A RARE ASSOCIATION
Authors: Malska Andriana , Kuryliak Olha , Telishevska Martha
Published: December 2023

We present a clinical case of the association of CCHB and HLHS in a newborn. The etiological relation between these two pathologies is unclear. According to the literature data, 70–90% of isolated CCHB are caused by maternal anti-Ro and anti-La antibodies, which cross the placenta and lead to fibrosis of the AV node or occur due to genetic defects, such as mutations in the SCN5A gene. Other theories suggest that compromised coronary blood flow in late fetal life could be a cause of CCHB, as the AV-node artery is the first and longest inferior septal branch of the right (90%) or left (10%) coronary artery, arising from U- or V-shaped segment of the corresponding artery at the level of the crux cordis. In our case, the level of maternal auto-antibody titers was unknown. It is possible that the heart block could be linked to the structural heart defect – HLHS, which could be the cause of hypoperfusion of AV node in fetal life. Only two similar cases of such combination are described in the literature.
CREATIVITY AND ORIGINALITY ARE KEY ELEMENTS IN MEDICAL RESEARCH: RECENT ILLUSTRATION BY THE 2023 NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE TO KATALIN KARIKO AND DREW WEISSMAN
Authors: Szabo Sandor , Zayachkivska Oksana
Published: December 2023

For at least a century, an often-debated topic is what is of primary importance to make breakthrough in biomedical research: originality/creativity or sophisticated methods/equipment. We present here a short historical overview arguing about the importance of creativity, originality, and persistence. Namely, the best living example of this is the 2023 Nobel Prize in Physiology or Medicine awarded to Drs. Katalin Kariko and Drew Weissman for the invention and development of mRNA-based vaccine against COVID-19. Katalin Kariko had a life-long obsession to use mRNA for cancer therapy, but when the structure of SARS-CoV-2 was announced, she shifted her interest to develop an mRNA-based vaccine against the new virus. But since the mRNA molecule is notoriously unstable and easily degraded if injected intracellularly, she teamed up with Dr. Weissman who was working on techniques to deliver mRNA molecules intracellularly. This creative teamwork with original ideas of vaccine development illustrates what other creative scientists, like Alexander Flemming, Hans Selye, Leon Popielski and James Black discovered in their fields. The sad part of the story is that only two of these scientists got the Nobel Prize.
BOHDAN YEVHEN NADRAGА – A DOCTOR BY DESTINY’S CALLING
Authors: Nadragа Marta , Holyk Roman , Lonchyna Vassyl A. , Nadraga Melania-Iryna
Published: December 2023

The year 2022 marks the 100th anniversary of Bohdan Yevhen Nadragа’s birth (1922–2018): A medical doctor, an active member of the SHEVCHENKO SCIENTIFIC SOCIETY (SSS) and the UKRAINIAN MEDICAL ASSOCIATION (UMA), and one of the promoters of the restoration of the traditions of Galician medicine.
The purpose of the article is to show the figure of Bohdan Yevhen Nadragа in the context of the history of medicine, scientific and professional interests, and reader preferences based on his own memories and the collective memory of him as a doctor.
Bohdan-Yevhen Nadragа was born on March 24, 1922, in Lviv, in the family of lawyer Oleksandr Nadragа and one of the first Galician Ukrainian doctors, Theodosia Tuna-Nadragа. The father passed on a keen sense of moral and legal justice to his son, while the mother – an interest in medicine. His love of medicine and biology was facilitated by his matriculation at the Lviv Academic Gymnasium in the conditions of interwar Poland. After graduating from the gymnasium, B. Nadragа entered Lviv State Medical Institute, where he studied specialized medical courses organized by the German occupation authorities from 1941 to 1944 and graduated in 1945. Here, he entered postgraduate studies at the Department of Normal Physiology, but in October 1947, he was deported to Anzhero-Sudzhensk, Kemerovo Region (Siberia) with his family. There, he worked with his mother, first as a state farm worker and then as a district pediatrician. Only in 1959 was he able to return to Galicia, where he worked as a doctor and was the chief doctor (1966–1983) at Sambir City Children’s Hospital. In 1993, he returned to his native Lviv, where he began working in the methodological office of Lviv Regional Children’s Clinical Hospital (1993-2012). During 1993–1995, he served as the director of the Hospital named after Metropolitan Andrey Sheptytskyi (“Narodna Lichnytsia”), became a member of the board of the restored UMA, joined the work of the medical commission of the Shevchenko Scientific Society, and was the author and editor of many publications of these societies. As the head of the Council of Medical Ethics at UMA, he became one of the authoritative participants in ethical discussions in the medical environment in 1990–2000; he was interested in the history of Lviv medicine and promoted the image of Lviv and Galicia. Respected by everyone as a model doctor and patriot, he passed away on September 28, 2018, at the age of almost 97. The activities of Bohdan Yevhen Nadragа are part of the history of Lviv and Galicia and Galician medicine, in particular pediatrics, to which he devoted his entire professional life.
Evaluation of Antioxidant Activity, Total Phenolic Content, and Total Flavonoid Content of the Aerial Part of Canna edulis Ker Gawl.
Authors: Thi Van Anh Nguyen , Thanh Tung Bui , Hong Luyen Le
Published: December 2023

Canna edulis Ker Gawl. (CE) is an important agricultural plant in Vietnam. The whole plant is traditionally used to treat many different diseases. However, scientific evidence on the pharmacological effects and chemical composition of this plant is limited and focuses mainly on the roots. This study aimed to evaluate the antioxidant activity and quantify the total phenolic and flavonoid content of extracts from the aerial part of CE. The in vitro antioxidant effect was evaluated by DPPH and ABTS free radical scavenging methods. Total phenolic content was evaluated with the Folin-Ciocalteu reagent, and total flavonoid content was evaluated by the aluminum chloride colorimetric method. The results showed that the ethyl acetate fraction had the most antioxidant activity with the IC50 values for DPPH and ABTS of 103.73 ± 9.80 and 76.52 ± 3.57 µg/mL, respectively. In addition, the ethyl acetate fraction contained the highest total phenolic and total flavonoid content with values of 70.93 ± 7.18 mg GAE/g extract and 64.93 ± 5.75 mg QE/g extract, respectively. Therefore, the aerial part of CE, especially the ethyl acetate fraction, is a potential plant source for the investigation of antioxidant compounds.

Keywords: Canna edulis, antioxidant, flavonoids, phenolic, DPPH, ABTS.
Overview of the Research System Cost-effectiveness of Emicizumab in Preventing Bleeding for People with Hemophilia A
Authors: Van Thuy Ha , Thi Thu Thu Tran , Ngoc Nghia Nguyen , Thi Xuan Bui
Published: December 2023

Systematic review research helps provide more scientific evidence for doctors in drug use as well as policymakers for safe, rational, and effective drug use. Emicizumab was first approved by the FDA in 2017 for patients with congenital hemophilia A and was later approved for prophylaxis. However, the high cost of Emicizumab treatment makes it difficult for patients to access the drug as well as pay for this by the insurance fund. A systematic review of studies on Emicizumab in the world that meets the conditions inclusion and exclusion criteria shows that 7 out of 8 studies (accounting for 87.5%) showed results that helped reduce total costs and increase treatment effectiveness compared to the placebo or alternatives. One study (accounting for 12.5%) resulted in increased total costs and reduced effectiveness compared to the intervention substance. Of these seven studies, one study achieved cost-effectiveness, three studies did not achieve cost-effectiveness (because ICER was lower than the willingness-to-pay threshold), and three studies could not be concluded as to whether they achieved cost-effectiveness.

Keywords: Systematic review, cost, effectiveness, Emicizumab, Hemophilia A.
Modulatory Effects of Ginsenoside Saponins in Panax notoginseng on Steroid Hormones
Authors: Van Khanh Nguyen , Thanh Hai Nguyen , Homma Seijiro , Thi Thu Giang Vu
Published: December 2023

Natural compounds with structural similarities to endogenous hormones, such as alkaloids, coumestans, flavonoids, lignans, saponins, and stilbenes, have been recognized increasingly for their potential in preventing and treating endocrine disorders related to steroid hormones. Panax notoginseng (Burk.) F. H. Chen, a member of the Araliaceae family and commonly known as Sanqi or Tianqi, is a valuable herbal medicine used to treat various diseases. The majority of saponins (ginsenosides) found in Panax notoginseng belongs to the dammarane triterpenoid group, exhibiting beneficial biological effects, including the treatment of cardiovascular diseases, pain, inflammation, and injuries, as well as internal and external bleeding caused by injury. The aglycone portion of ginsenosides possesses a steroid-like hydrophobic four-ring structure, similar to steroid hormones. Recent studies have indicated that the Panax notoginseng ginsenoside saponins (PNS) have steroid hormone-like activities, bringing the potential for endocrine disorders treatment. Thus, this review aims to provide the chemical structure and steroid hormone-regulating effects of ginsenoside saponins in Panax notoginseng.

Keywords: Panax notoginseng, saponin, steroid hormone, ginsenoside, hormone-like effect.
In vivo Evaluation of Berberine-loaded Liposomes in the Exogenous Hyperlipidemia Animal Model
Authors: Thi Thuan Duong , Thi Quynh Trang Nguyen , Thuy Duong Nguyen , Thanh Hai Nguyen , Thi Minh Hue Pham
Published: December 2023

Berberine (BBR) is an alkaloid presenting exogenous cholesterol lowering and anti-hyperlipidemia therapeutic effects in the literature. In this study, the exogenous lipid-lowering effects of oral BBR-loaded liposomes were investigated in rats compared with free BBR within four weeks. The BBR-loaded liposomes at the daily oral dose of 25 mg BBR/kg of body weight in rats reduced total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) by 22.34% (p>0.05), 43.93% (p<0.05), respectively. These values (TC and LDL-C) when rats were given BBR-loaded liposomes at the daily oral dose of 50 mg BBR/kg were 30.72% (p<0.05) and 42.77% (p<0.05) compared with those values of the untreated control group, respectively. Both doses of BBR-loaded liposomes have no signals in decreasing triglycerides.

Keywords: Berberine, berberine-loaded liposomes, anti-hyperlipidemia, animal model.
Qualitative Evaluation for Asphalt Binder Modified with SBS Polymer
Authors: Al-Nawasir Rania I. , Al-Humeidawi Basim H.
Published: December 2023

Solutions for safer, more durable infrastructure are required in light of increasing traffic and severe weather in Iraq. The most significant road conservation and maintenance challenges are the pavement's low resistance to dynamic loads and short service life. As a result, vast sums of money are spent annually to enhance the road service capacities in Iraq. Thermoplastic electrometric polymers for bitumen modification create long-lasting, cost-effective roadways. This study aims to determine how the mechanical properties of neat asphalt binder change when styrene butadiene styrene (SBS) is added as a modifier. The current research investigates adding three percentages of SBS (3, 5, and 7% of the weight of bitumen). Both neat and polymer-modified bitumen (PMB) were subjected to a series of physical laboratory and Superpave tests, including a dynamic shear rheometer tester (DSR) and a storage stability test. In addition, a chemical analysis test was conducted to identify any change in the neat binder chemical composition due to the addition of SBS polymer. The results indicated that 5% of SBS polymer was the optimum addition percentage to the local asphalt in Iraq. Additionally, it reduced the susceptibility of bitumen to temperature changes and enhanced its characteristics in all laboratory tests. The obtained PMB significantly improved rutting and fatigue factors compared to the neat asphalt binder. Based on the DSR tester and the storage stability test, the ratio of 5% SBS met the requirements of class PG76-10, used in the central and southern governorates of Iraq. Using SBS polymer on the surface course in Iraq reduces road damage due to the scorching summer sun, reduces the likelihood of rutting and fatigue cracking, and works well in hot regions, resulting in roads that last longer, provide comfortable riding, and require less maintenance.
The search for new methodological approaches in legal research in the context of modern challenges
Authors: Bleshchik Aleksandr Vladimirovich
Published: December 2023

The subject of this article is theoretical concepts and explanatory models used in legal science to identify the essence of law and legal phenomena, as well as issues of the evolution of methodological knowledge in jurisprudence in modern conditions. Due to the lack of adequate tools in classical jurisprudence for describing and researching the nature of new phenomena of legal reality, as well as in connection with overcoming politically and socially determined methodological limitations, legal science is faced with the need to search and disseminate new methodological approaches. New methodological approaches in the social sciences in general and in jurisprudence in particular do not pretend to establish the absolute truth, their advantage lies in the integration of traditional approaches. When considering the problems of the methodology of modern legal research, the author points out the need to apply new postclassical approaches, including the communicative theory of law. The novelty of the research consists in substantiating the impossibility of the transition of legal science to a qualitatively new level of knowledge of law and legal phenomena, provided that it uses the classical (and to a certain extent outdated) methodological optics. Since legal science develops in the context of the development of scientific knowledge in general and goes through the same stages in its development, at the present stage its development may be associated with the application of integrative concepts of legal understanding. One of the most interesting integrative concepts of legal understanding is the communicative approach, which allows us to give a more complete picture of the law, of all legal institutions, as it introduces legal dogmatics into the context of social communication. The communicative approach offers legal science new tools for understanding law and legal phenomena in their social dimension, which is the basis for using it as a methodological basis for current research in the field of lawmaking and law enforcement.
Students Are Happier In Madrasah: The Results of Bayesian Analysis on Indonesian National Survey Data
Authors: Patria Bhina
Published: December 2023

Islamic education is an important part of the Indonesian education system. This is not only because Indonesia is the biggest Muslim country in the world, but also because Islamic education has a social, cultural, and political role in Indonesian society. Nevertheless, madrasahs in Indonesia face several challenges entrenched from financial constraints. This leads to adverse consequences such as restrictions in the provision of infrastructure, inadequate quality of teachers, and low academic achievement in the national exam. Furthermore, students in madrasahs have more burdens than those in regular schools; for instance, students in madrasahs have more subjects to study, longer school hours, and must adhere to stricter rules and conduct. The challenges faced by madrasah raise concerns regarding its effects on students’ subjective well-being. Therefore, the present study aims to investigate whether there is a difference in students’ happiness between those who attend madrasahs and the regular schools. The data collected were based on the results of face-to-face interviews with 1,299 secondary education students in Indonesia. The results of the Bayesian ANCOVA analysis showed that the best-fitting model for predicting students’ happiness contained type of school and wealth level as predictors. The results also showed that the happiness level of madrasah students was significantly higher than their counterparts in regular high school. The finding is noteworthy because students’ happiness in madrasah is higher than in the regular school, despite the lower level of wealth. The results further discussed the literature on religiosity and happiness in the context of adolescent education.
The Evolution of Islamic Counseling: A Bibliometric Analysis of Trends in Publications from 1981-2023
Authors: Ifdil Ifdil , Zatrahadi Fahli , Hasibuan M Fauzi , Abdullah Nor Zaiham Midawati , Bah Yahya Muhammed , Bakar Abu Yazid Abu , Nurkholidah Enik
Published: December 2023

The objective of Islamic counseling is to focus on incorporating religious values into therapy, offering valuable guidance for individuals who are grappling with psychological and social problems. Therefore, this study aimed to examine the trends in Islamic counseling publications from 1981 to 2023. A qualitative bibliometric method was used to collect data from Scopus database on August 25, 2023. Approximately 244 relevant papers were identified as the sample used for the analysis. Data analysis was conducted using software such as Openrefine-3.6.0, VOSviewer 1.6.18, and Biblioshiny R The results showed that the highest topic trend was recorded in 2020, with 26 citations. Beekun and Badawi held the highest position with a combined score of 281 in terms of publication. Additionally, Rothman, A. and Tahlil, T. were the authors who made significant contributions to the field, each with 4 documents. This study examined 6 clusters, discussing the keywords associated with Islamic counseling. The keywords consisted of the Development of Mental Well-being in Adults through Counseling, Ethics, Morality, and Human Rights in Education and Public Awareness. Furthermore, they included Controlled Human Studies with Gender Type Factors, Treatment of Depression with an Islamic Psychotherapy Approach, Health Services for the Elderly Muslim Community, and Islamism's Influence in Alleviating Poverty through Religious Aspects.
The Correlation between Event and Life Satisfaction and Curiosity and Discovery Levels of Individuals Participating in Activities in Recreational Areas
Authors: AKYÜZ Fırat , GÜNGÖRMÜŞ Hamdi Alper , KAYSERİLİ Alperen
Published: December 2023

The aim of this research is to determine the levels of curiosity and exploration, event and life satisfaction levels of individuals participating in activities in these areas and compare these levels according to various demographic variables. The universe of the study is the individuals in Erzurum city. The sample group consisted of 1140 volunteers, 585 males and 555 females, who attended activities in recreation areas. In this research, recreation areas of Erzurum city were determined and ARCGIS 10.5 program based on GPS systems and geographic information systems were used to map these areas. The "The Curiosity and Exploration Inventory" (CEI-II), " Event Satisfaction Scale" (ESS) and "Life Satisfaction Scale" (LSS) were used as data collection tools in the study. Descriptive statistics, independent samples t-test, ANOVA and Simple Correlation tests were used in the analysis of the obtained data. Cronbach's Alpha analysis was carried out to determine the reliability of measurement tools. According to the findings obtained, “age", "marital status" and "educational status", a statistically significant difference was found in all scale scores of the variables whereas according to the variable "place of participation in activities", there is statistically significant difference in "ESS" and "LSS". According to the correlation between the scales, it was found that there is only a positive and low level statistically significant correlation between the total average scores of the “LSS” and the total average scores of the “ESS”. It was concluded that the levels of curiosity and exploration, event satisfaction, and life satisfaction of the participants differ according to their various demographic characteristics and that the higher the satisfaction obtained from the activities, the higher the life satisfaction.
Estimating the trajectories of rising smoke mixtures from high-altitude pipes using satellite information
Authors: Амикишиева Р.А. , Рапута В.Ф. , Леженин А.А.
Published: December 2023

Обсуждаются методы численного построения траекторий подъема дымовых шлейфов от высотных труб тепловых станций. При проведении исследования в качестве базовых применяются соотношения, вытекающие из соображений размерности и подобия, применительно к струям, поступающим в сносящий поток. Пространственное расположение точек на осях дымовых струй определяется с помощью спутниковых снимков, которые позволяют фиксировать направление сноса шлейфов и положение их теней на земной поверхности. Учитываются угловая высота и азимут солнца. Характеристики скорости ветра и температуры в нижней тропосфере устанавливаются на основе данных аэрологического зондирования. Апробация предложенного подхода по оцениванию траекторий подъема дымовых шлейфов выполнена на выбросах газоаэрозольных смесей от высотных труб НовоИркутской ТЭЦ и Гусиноозерской ГРЭС. Для численного анализа использовались зимние спутниковые снимки территорий, на которых расположены эти объекты энергетики. С помощью соотношения, описывающего аналитическую связь между текущей высотой подъема дымовой струи и ее горизонтальным смещением в рамках “закона 2/3”, получены вполне удовлетворительные аппроксимации рассматриваемых траекторий. Выполнены оценки высот подъема и потоков плавучести дымовых шлейфов. Полученные результаты могут быть использованы для внешнего контроля режимов эксплуатации тепловых станций.

Methods for numerically constructing trajectories of rising smoke plumes from high-rise pipes of thermal power plants are discussed. When carrying out the study, the relations arising from dimension and similarity considerations are used as fundamentals for description of the jets entering the drift flow. The spatial location of points at the axes of smoke plumes is determined using satellite images, which allows recording the direction of drift of plumes and the position of their shadows on the Earth’s surface. This takes into account the angular altitude and azimuth of the sun. Characteristics of wind speed and temperature in the lower troposphere are established on the basis of upper-air sounding data. The proposed approach for assessing the ascent trajectories of smoke plumes was tested on emissions of gas-aerosol mixtures from the high-rise chimneys of the Novo-Irkutsk Thermal Power Plant and Gusinoozerskaya State District Power Plant. To carry out the numerical analysis, we use winter satellite images of the territories where these energy facilities are located. Using the relationship that describes the analytical relationship between the current height of the rise of the smoke jet and its horizontal displacement within the framework of the so-called “2/3 law”, quite satisfactory approximations of the considered trajectories were obtained. Estimates for the heights and buoyancy flows of the ascenting smoke plumes have been carried out. The obtained results can be used for external monitoring of operating modes of thermal power plants.
Numerical method for clustering climate data
Authors: Волков Ю.В. , Кавешников А.В.
Published: December 2023

Описан разработанный метод кластеризации данных, пригодный для анализа и систематизации климатической информации, представленной массивами средних численных значений климатических характеристик. Описан алгоритм применения теории аналитического сигнала для подготовки исходных данных. В качестве критериев кластеризации использованы амплитуды и фазы исходных сигналов. С применением предложенного метода кластеризации получены климатические классы для Байкальской природной территории для разных временных интервалов. В качестве исходной информации использовались массивы данных о приземной температуре и атмосферном давлении.

Summary. The purpose of this research is to identify climate classes for the Baikal natural territory during various time intervals. Methods. The study uses climatic characteristics such as surface temperature and atmospheric pressure. A mathematical model of the climate signal was constructed in the form of a quasi-periodic oscillation caused by the global annual cycle of the Earth’s rotation, modulated in amplitude and phase. The carrier oscillation has a period equal to one calendar year. An essential task is to establish patterns of changes in the Earth’s climate system based on the parameters of the amplitudes and phases of climate characteristics. For this purpose, a dynamic clustering algorithm was employed. Experiment. An array of climate data was generated, which included the following meteorological characteristics: temperature and pressure, measured at weather stations located in the Baikal Natural Territory (BNT). The purpose of the experiment is to construct a characteristic for classes of BPTs and assess their variability with regard of the amount of spatial structure over time using the developed algorithm. Results. The presented results have shown that the composition and structure of climate clusters is changed during various time intervals. On average, for all data and periods, it was possible to determine two conditional places of stable formation of clusters. Conclusions. The advantage of the proposed method is that it allows, based on the determination of typical patterns, identifying unique clusters without any a priori information about the number or other parameters of clusters. The resulting climate classifications can be used to assess changes in regional climate at various time and spatial scales.
Model of microgrid agent behavior
Authors: Бычков И.В. , Феоктистов А.Г. , Чекан М.А.
Published: December 2023

Статья посвящена проблеме интеллектуализации обработки и анализа данных в исследовании процессов функционирования микросетей как экологически чистых и ресурсосберегающих систем энергетики. Процесс моделирования взаимодействия микросетей реализуется мультиагентной системой. Рассмотрены структура мультиагентной системы, средства ее построения, назначение и процессы функционирования агентов. Разработана модель поведения агента, базирующаяся на использовании конечного управляющего автомата. Мультиагентная система ориентирована на поддержку исследования живучести автономных энергетических систем инфраструктурных объектов Байкальской природной территории.

A microgrid is a network having a diverse spectrum of energy generators and storage devices. Generally, it has a relatively small local loads. Energy management in such networks has a number of advantages, such as reducing power losses and simplifying the management process. To this end, the need to study various aspects of organizing and operating microgrids from the point of view for managing their functioning is significantly increases. In this regards, the paper addresses an intellectualization of data processing and analyzing within the study of micro-grids as environmentally friendly and resource-saving energy systems. We consider microgrid interactions under external disturbances. The process of modelling the interaction of microgrids is realized by a multi-agent system. The multi-agent system structure, tools of its construction, and purpose and functioning of agents are considered. Moreover, we developed and presented a model of agent behavior that is based on the use of a finite control machine. The multi-agent system is implemented using the JADE framework. To reduce labor costs for creating agents, we have developed a special add-on to JADE for determining the agent behavior. The considered multi-agent system is focused on supporting the study of the resilience of autonomous energy systems for infrastructure objects located on the Baikal natural territory.
Absolute Zeta fountions for Zeta functions of quantum cellular automata
Authors: Akahori Jiro , Konno Norio , Sato Iwao
Published: December 2023

Our previous work delt with the zeta function for the interacting particle system (IPS) including quantum cellular automaton (QCA) as a typical model in the study of ``IPS/Zeta Correspondence". On the other hand, the absolute zeta function is a zeta function over $\mathbb{F}_1$ defined by a function satisfying an absolute automorphy. This paper proves that a new zeta function given by QCA is an absolute automorphic form of weight depending on the size of the configuration space. As an example, we calculate an absolute zeta function for a tensor-type QCA, and show that it is expressed as the multiple gamma function. In addition, we obtain its functional equation by the multiple sine function.
Progress on the Kretschmann-Schlingemann-Werner Conjecture
Authors: vom Ende Frederik
Published: December 2023

Given any pair of quantum channels $\Phi_1,\Phi_2$ such that at least one of them has Kraus rank one, as well as any respective Stinespring isometries $V_1,V_2$, we prove that there exists a unitary $U$ on the environment such that $\|V_1-(\mathbbm1\otimes U)V_2\|_\infty\leq\sqrt{2\|\Phi_1-\Phi_2\|_\diamond}$. Moreover, we provide a simple example which shows that the factor $\sqrt2$ on the right-hand side is optimal, and we conjecture that this inequality holds for every pair of channels.
Screening and Simulation Study of Efficacious Antiviral Cannabinoid Compounds as Potential Agents Against SARS-CoV-2
Authors: Devi Mahima , YADAV VIVEK
Published: December 2023

The proliferation of severe acute respiratory syndrome corona-virus 2 (SARS-CoV-2) and the persistent corona-virus disease 2019 (COVID-19) pandemic emphasize the necessity for novel treatments. Among the diverse pharmacological agents under scrutiny, cannabinoids have garnered attention for their potential antiviral properties. This study utilizes molecular docking and simulation techniques to explore the interaction between cannabinoid drugs and essential SARS-CoV-2 viral proteins to identify potential therapeutic effects. The results suggest favourable binding energies between certain cannabinoid drugs and viral proteins, especially at the active sites of the spike protein. Our computational findings reveal that the ligands Cannabiscitrin and Cannabisin D exhibit the highest binding affinity (approximately -9.11 and –8.84 kcal/mol, respectively) toward the SARS-CoV-2 receptor, while Alacepril displays the lowest affinity (–6.32 kcal/mol) for the SARS-CoV-2 receptor. The findings suggest a potential inhibitory effect of cannabinoid drugs on both viral entry and replication. Furthermore, simulations demonstrate cannabinoid binding to the CB2 receptor, suggesting potential immunomodulatory roles in SARS-CoV-2 infection. This research underscores the promise of cannabinoids as SARS-CoV-2 therapeutic agents, necessitating further validation and clinical exploration.
INFLUENCE OF PAST SARS-CoV-2 INFECTION ON MENSTRUAL ON WOMEN OF EARLY REPRODUCTIVE AGE
Authors: B.T Begalieva , M.S. Shelygin , I.V. Batinova , V.Y. Rud , A.E. Tanchuk
Published: December 2023

The pandemic has had a significant impact on the lives of people around the world. Both those who have directly had a coronavirus infection, and those who have been exposed to stress in conditions of social isolation, deteriorating financial well-being and other changes associated with long-term quarantine. Human existence is subject to biological rhythms, adapting the body to changing environmental conditions. One of the most important regulatory roles is played by circadian (daily) rhythms, namely the cycle of sleep and wakefulness. Pineal hormone - melatonin, is involved in the regulation of pigment metabolism, but its main effect is inhibition of the secretion of gonadotropins. In women, the highest level of melatonin is observed during menstruation, the lowest - during ovulation. This hormone plays an important role in the female reproductive system. In turn, SARS-CoV-2 can cause mental disorders by affecting the central nervous system. The most common symptoms and conditions: headaches and dizziness, taste and smell disorders (hyposmia and anosmia), weakness, anxiety, obsessive-compulsive disorders, insomnia, impaired attention and concentration. With prolonged illness, serious disorders of the central nervous system are observed. This study aims to correlate changes in sleep quality and changes in menstrual function in patients who have had SARS-CoV-2 infection.
STUDY OF THE AMINO ACID COMPOSITION OF THE BI-COLOR LESPEDESIA GROWING IN THE KRASNODAR REGION
Authors: M.R. Hochava , T.E. Onbysh
Published: December 2023

As is known, biologically active compounds in plants are in complexes easily absorbed by the human body and in biologically available concentrations, therefore they have a higher phar-macological activity compared to synthetic analogues. Plants synthesize all the amino acids necessary to build protein molecules. The ability of plant amino acids to participate in the as-similation of other biologically active substances by the body, as well as a wide range of their biochemical, and as a result, pharmacological action, attracts more and more attention of re-searchers and the study of the composition and content of amino acids in medicinal plant raw materials as potential sources of drugs. That is why the study of the qualitative and quantita-tive content of amino acids in medicinal plant raw materials and in preparations derived from it is of great practical importance and of a certain scientific interest.
The experience of using shoots of Lespedeza bicolor in official and folk medicine tes-tifies to its wide therapeutic possibilities, which served as the basis for research to clarify its chemical composition in relation to amino acids. This paper presents data on the qualitative and quantitative amino acid composition of the aerial organs of Lespedeza bicolor (Lespedeza bicolor L, plant family Fabaceae) growing in the Krasnodar Territory. A comparative study of the main essential and non-essential amino acids in flowers, leaves and shoots of Lespede-za bicolor was carried out by capillary electrophoresis. It has been established that the flowers and leaves of Lespedeza bicolor contain 11 amino acids each, the dominant amino acid of both flowers and leaves is proline; Lespedeza bicolor shoots contain 12 amino acids, 6 of which are essential (threonine, valine, methionine, leucine, phenylalanine, lysine). Leucine is present only in the leaves, and cysteine only in the flowers of the studied plant
EXPERIENCE IN IMPLEMENTING A SYSTEM OF MONITORING AND CENTRALIZED MANAGEMENT OF ANTITUMOR DRUGS PROCUREMENT BY MEDICAL ORGANIZATIONS IN THE SVERDLOVSK REGION
Authors: D.A. Demidov , A.A. Karimova
Published: December 2023

The limited financial capabilities of regional healthcare require administrators to constantly search for new ways to optimize the costs of procurement of drugs, especially for resource-intensive nosologies, among which oncological diseases play a key role. The purpose of the work was to highlight the experience of implementing a system of centralized monitoring and procurement of antitumor drugs to provide regional hospitals, as well as to demonstrate the organizational effects of this management decision. The research materials included information on the procurement of antitumor drugs in 38 medical organizations for 106 drugs, presented in 156 reports on the newly approved form of monitoring their availability, including purchased drugs under 42 joint state contracts in 2023 and independently concluded contracts of medical organizations with suppliers outside the centralized system. The materials of the study were also local regulatory and administrative documents issued during the initiation and operation of the system of centralized purchase of chemotherapeutic drugs by the region in 2022-2023. Research methods: structural, system analysis, content analysis of regulatory documents and reporting documentation of medical organizations. As a result of the study, an algorithm was compiled for the implementation of a centralized procurement management by medical organizations within the Sverdlovsk region, indicating the necessary administrative steps towards the creation of this system, as well as the recommended form of reporting documentation for controlling the volume of procurement of drugs. The work showed the positive aspects of the regional experience and problematic aspects that require further solutions. This experience is recommended for implementation in other regions using the developed form of monitoring the availability of antitumor drugs in hospitals.