bluuebunny/crossref_metadata_2025 huggingface dataset:
Rehabilitation of patients with сhronic disorders of consciousness
Authors: Kanarskii M. M. , Nekrasova J. Yu. , Borisov I. V. , Borodin M. M. , Roshka S. F. , Bondar V. A. , Matafonova S. N.
Published: January 2021

Chronic disorders of consciousness is a complex medical and social problem. Rehabilitation of these patients is one of the most important tasks from both practical and scientific points of view. The lack of a standardized approach and techniques with a large evidence base in the restoration of consciousness, the need for multidisciplinary teams in the rehabilitation process, difficulties in creating a rehabilitation environment, as well as many other problems are acutely faced by patients relatives, doctors, healthcare organizers, scientists. In this article, we will consider approaches to the rehabilitation of patients with chronically impaired consciousness.
Topical issues of medical and social assistance to elderly and senile citizens in the conditions of inpatient social service organizations
Authors: Memetov S. S. , Pusin S. N. , Budnik N. V. , Kobzev Yu. V. , Petrova V. N. , Kim V. V.
Published: January 2021

The article analyzes the current regulatory and legal framework for the organization of social services for the elderly and disabled in social service institutions on the territory of the Russian Federation. The article reflects the shortcomings of legal documents regarding the organization of work of such institutions to improve the quality and accessibility of social care for patients receiving social services in social service organizations. The assessment of staffing standards is given.
Early childhood rehabilitation as a component of demographic policy in the Russian Federation
Authors: Borisov I. V. , Bondar V. A. , Kanarskii М. М. , Nekrasova J. Yu.
Published: January 2021

In the President's Address to the Federal Assembly of the Russian Federation in 2020 V.V. Putin clearly outlined the improvement in the social sphere, including material support for the family at the birth of the first and next children. Undoubtedly, such measures will help increase the population in our country. On the healthcare side, there is a potential need to address the increased burden on obstetric and child health providers. An important role in the provision of medical care is played by the rehabilitation service for newborns with various perinatal diseases.
Surgical treatment of patients with sagittal imbalance of degenerative etiology: a comparison of two methods
Authors: Baykov Evgenii S. , Peleganchuk Alexey V. , Sanginov Abdugafur J. , Leonova Olga N. , Krutko Aleksandr V.
Published: January 2021

Purpose. Compare the clinical and radiological results of treatment of patients with spinal deformities operated on using the PSO method and corrective fusion in the lumbar spine.
Materials and methods. Retrospective monocenter cohort study. The data of 42 patients were analyzed. PSO (group I) was performed in 12 patients; 30 patients had a combination of surgical methods (group II) with mandatory ventral corrective spinal fusion at levels L4-L5, L5-S1. Clinical and radiological parameters were evaluated during hospitalization and at least 1 year later.
Results. Postoperative hospitalization in group I 32.5 7.4 days, 27.1 7.4 in group II (p = 0.558758). The duration of the operation in group I was 402.5 55.6 minutes, in group II 526.0 116.2 minutes (p = 0.001124); blood loss 1862.5 454.3 ml versus 1096.0 543.3 ml (p = 0.000171). In both groups, significantly improved clinical and radiological parameters after surgery and after 1 year (p 0.05). In group II, as compared with group I after surgery and more than 1 year: lower back pain according to VAS (p = 0.015424 and p = 0.015424); below ODI after 1 year was (p = 0.000001). In group I, compared with group II after surgery and after 1 year, SVA is less (p = 0.029879 and p = 0.000014), lumbar lordosis is higher (p = 0.045002 and p = 0.024120), LDI is restored more optimally (p = 0.000001 and p = 0.000002), the GAP is lower (p = 0.005845 and p = 0.002639). The ideal Russoly type is restored more often in patients of group II (p = 0,00032). Complications in group I were noted in 12 (100%) patients, in group II in 13 (43.3%) patients (p = 0.001).
Conclusions. In multistep surgical treatment compared with PSO, the anterior corrective interbody fusion L4-L5, L5-S1 reliably better and more harmoniously restores the sagittal balance parameters, has significantly lower volume of intraoperative blood loss, fewer perioperative complications and significantly improves the quality of life of patients.
Treatment of suprascapular neuropathy
Authors: Orletskii Anatoly K. , Timchenko Dmitriy O. , Gordeev Nikolay A. , Krylov Sergey V.
Published: January 2021

Aim. Evaluation of the results of surgical treatment of patients with neuropathy of the suprascapular nerve.

Materials and methods. In the department of sports and ballet injury of CITO them N.N. Priorov in 20132014 11 arthroscopic decompression of the supramandular nerve were performed. All patients underwent radiography and MRI of the shoulder joint and electroneuromyography of the brachial plexus.

Results. After decompression, all patients underwent repeated electroneuromyography 2 months after the operation, then according to indications. In all cases, an increase in M-response was noted. A complete recovery of clinically and an increase in the M-response of more than half the norm (contralateral) and more to the normal value was observed after 58 months.

Conclusion. The use of modern minimally invasive methods of surgical etiotropic treatment of the neuropathy of the suprascapular nerve helps to achieve, as a rule, good and excellent results, even in old cases.
Anterior stabilization of spine column in the staged surgical treatment of patients with fractures of thoracic and lumbar vertebrae with low bone mineral density
Authors: Afaunov Asker A. , Basankin Igor V. , Takhmazyan Karapet K. , Giulzatyan Abram A. , Mukhanov Mikhail L. , Chaikin Nikita S.
Published: January 2021

Aim. To determine the clinical effectiveness of anterior stabilization in the surgical treatment of patients with traumatic injuries of the thoracic and lumbar spine with reduced bone mineral density.
Materials and methods. The study included 238 patients with thoracic and lumbar vertebral fractures with reduced bone mineral density (BMD). The age of patients is from 48 to 85 years. There are following types of fractures according to F. Magerl (1992): A1.2, A1.3, B1.2, B2.3. BMD of the vertebrae was decreased (T-score from 1.5 to 3.5).
Results. All patients underwent short segment transpedicular fixation (TPF) with four-screw systems. In group 1 were included 68 patients who underwent TPF without cemented augmentation of screws. Group 2 included 170 patients who underwent TPF reinforced with a cement. Both groups were divided into 2 subgroups. Subgroup 1.1 included patients, which were operated on in two stages. The first stage is TPF. The second stage is the anterior stabilization. Subgroup 1.2 included patients who underwent only TPF. Patients in group 2 were divided into two subgroups in a similar way. The results and complications according to clinical and spondylometric criteria were studied. Correlation analysis was performed between surgical technique, surgical tactics and the treatment results in the four selected subgroups. The observation period is at least 2 years.
Conclusion. 1. When using TPF with cement augmentation for the treatment of patients with fractures of the thoracic and lumbar spine with reduced BMD, the anterior stabilization of injured spinal motion segment as a second stage of surgical treatment does not provide clinical advantages compared to the use of only TPF with cement augmentation. 2. In case of cementless TPF in patients with reduced BMD, anterior stabilization of the injured spinal motion segment is necessary. Only when anterior stabilization is performed, the stability of fixation is ensured. It is sufficient to preserve the anatomical relationships restored during the operation and functional adaptation of patients in the long-term period after surgery.
IN VITRO BIOLOGICAL ACTIVITY EVALUATION OF ETHANOLIC EXTRACT OF MELICA UNIFLORA LEAVES
Authors: ÇİL Elif , TÜRKİŞ Sevda , ÇOL AYVAZ Melek , BÖRÇEK KASURKA Ceren
Published: January 2021

Melica uniflora is part of the omnivore and
herbivore animal diets and there is not enough study about this plant. The aim
of the study is to provide the antimicrobial and antioxidant potential of
ethanol extract of M. uniflora leaves. 
Total phenolic and
flavonoid contents and antioxidant potential based on different methods and
antimicrobial activity of M. uniflora leaves ethanol extract were examined.
Disk diffusion method against to
eight bacteria strains, the Folin-Ciocalteu
method, DPPH free radical scavenging activity and ferric reducing
antioxidant power assays were used. Mean diameters of inhibition zones were found in the range of
14.93 mm to 26.32 mm.
The total phenolic content of ethanol extract of M. uniflora leaves was
determined as 0.466 mg GAE/g. Total antioxidant activity value of the extract was
calculated 4.54 mg AAE/g. IC50
value was calculated 18.798 mg/mL for DPPH free radical scavenging activity.
The FRAP value indicated that the reducing
power of 1 gram of sample was equivalent to 3.33 µmol of trolox. The flavonoid
content of the extract was calculated as
4.44 mgQE/g. According to the obtained results, the analyzed M.
uniflora leaves ethanol extracts demonstrated antioxidant and antimicrobial
activity level can be considered effective.
Structural measures against floods on the Spanish Mediterranean coast. Evidence for the persistence of the “escalator effect”
Authors: Pérez-Morales Afredo , Romero-Díaz María Asunción , Gil-Guirado Salvador
Published: January 2021

The risk of flooding on the Spanish Mediterranean coast is a constant threat whose importance has progressively increased in recent decades despite the enormous efforts made to mitigate it. Of the two strategies practiced to reduce the effects of this danger, structural measures have prevailed to a great degree over non-structural ones during this period of increased risk. Here, these works carried out from the beginning of the 20th century to the present are cataloged, with a double objective: (i) to show the evolution of the number of infrastructures, their typology, and their distribution on the Mediterranean coastline; and (ii) to evaluate whether the basins with and without a dam have followed differing trends in the occupation of floodplains to show the persistence of the “escalator effect”. The results obtained indicate that there is no statistically significant difference between the occupation of the floodplainsby basins with and without a dam for the Return Periods (RP) 50, 100, and 500 years. However, for RP10, there is a higher occupation by basins with a dam.
Factors Determining the Perceived Security Dimensions in B2C Electronic Commerce Website Usage: An Indonesian Study
Authors: Marianus Santos , Ali Syaiful
Published: January 2021

Research aims: This study aims to analyze the perceived security dimensions and build a research model using perceived ease of use and perceived usefulness as variables mediating the link between perceived security and the intention to use Indonesia's B2C e-commerce websites. Design/Methodology/Approach: Using a purposive sampling approach, this study conducted an online survey of respondents who had done online transactions, such as business-to-customer (B2C) transactions. Research Findings: The study's results showed that perceived security significantly correlated with buyers' intention to use B2C websites. Theoretical contribution/Originality: This study contributes to developing and validating key dimensions of perceived security and their constructs. Mediation effect test results from TAM, which were perceived ease and perceived use, indicated that only the perceived usefulness variable significantly mediated the relationship between perceived security and intention to use B2C e-commerce websites. Perceived use's mediation was not supported. Practitioner/Policy implication: This research empirically supports the perceived security construct as a second-order construct involving confidentiality, availability, non-repudiation, and privacy. Research limitation/Implication: This study used data from Indonesian individuals, which may differ from other countries' characteristics. It may limit the research' finding generalization. Research aims: This study aims to analyze the perceived security dimensions and build a research model using perceived ease of use and perceived usefulness as variables mediating the link between perceived security and the intention to use Indonesia's B2C e-commerce websites.Design/Methodology/Approach: Using a purposive sampling approach, this study conducted an online survey of respondents who had done online transactions, such as business-to-customer (B2C) transactions.Research Findings: The study's results showed that perceived security significantly correlated with buyers' intention to use B2C websites.Theoretical contribution/Originality: This study contributes to developing and validating key dimensions of perceived security and their constructs. Mediation effect test results from TAM, which were perceived ease and perceived use, indicated that only the perceived usefulness variable significantly mediated the relationship between perceived security and intention to use B2C e-commerce websites. Perceived use's mediation was not supported.Practitioner/Policy implication: This research empirically supports the perceived security construct as a second-order construct involving confidentiality, availability, non-repudiation, and privacy.Research limitation/Implication: This study used data from Indonesian individuals, which may differ from other countries' characteristics. It may limit the research' finding generalization.
New Remuneration System for Village Government Apparatus (APD): Can it Halt Fraud Incident(s)?
Authors: Yuliastina Mellani , Hudaya Muhammad , Nor Wahyudin , Ainun Basyirah
Published: January 2021

Research aims: Central and local governments are trying to curbing fraud involving the village government apparatus (APD) by increasing the remuneration of APD, so that they are not tempted to misuse the village fund that they manage.Design/Methodology/Approach: The purpose of this study is to see whether remuneration is the cause of fraud, the extent to which the application of new PPE remuneration has an impact on reducing the potential for fraud and who is the main actor in fraud. This research uses a qualitative approach, and case study strategy research. The research was carried out in in three villages within a district, Regency of Barito Kuala, South Kalimantan. Data were collected through several relevant informants interviewed using the open-ended questions technique.Research findings:  The results of this study indicate that APD is required to be professional to carry out their duties in managing village development, but on the other hand, the compensation for workload received is not commensurate with the risks faced. However, the increase in remuneration for the APD is only happened to the village head and village secretary, while the head of affairs and head of section’s renumeration remain below regional standard pay (UMR). The main cause of fraud is in the aspect of hegemony power and governance.Theoretical contribution/ Originality: The new remuneration system is supposed to curb the potential fraud, however, it leaves new loopholes for committing fraud. The paper suggests the new renumeration system needs to be revamped, in which all APD should receive minimum pay at UMR level, Improved governance, encouraging community participation and eliminating stereotypes about power as an effort to achieve prosperity.Research limitation/Implication: This research was conducted using a qualitative approach where the results of this study cannot be generalized to a wider scope.
Analysis of Young Generations toward Stock Investment Intention: A Preliminary Study in an Emerging Market
Authors: Nugraha Bagus Aditya , Rahadi Raden Aswin
Published: January 2021

Research aims: This study attempts to analyze the young generations' perceptive variables in Indonesia, namely millennial (generation Y) and generation Z toward stock investment intention preliminarily.Design/Methodology/Approach: This study posits perceptive variables from the Theory of Planned Behavior (TPB) with various demographic characteristics as tablemoderating variables. This study utilized a structured online questionnaire survey to collect 64 samples and being analyzed by PLS-SEM. The group differences that being examined were investigated with multi-group analysis.Research findings: The findings from this study revealed that not all perceptive variables from TPB were significant on young Indonesian generations toward stock investment intention; only attitudes toward behavior had a significant effect. These findings were contrary to prior literature. Besides, Indonesia's young generations’ education level also played a moderating role in influencing stock investment intention. Theoretical contribution/Originality: This preliminary study provides potential facts regarding the applicability of the Theory of Planned Behavior in the emerging market (Indonesia) in stock investment intention.Practitioner/Policy implication: The practical contribution would be insights for policymaker and Securities Firms regarding young generations’ perspective on stock investment and what possible actions in terms of policies, programs, and campaigns that need to be done to increase the growth of investors’ number in Indonesia. For public firms, the insights could be useful in constructing sustainability strategies in terms of funding source from the firm’s stock.Research limitation/Implication: The sample used for this preliminary study was restricted to young generations divided into generation Y and Z from Indonesia only. This study focused on the fundamental implementation of TPB only; hence, the individual behavioral intention analysis was limited to TPB proxies. Since an online survey using a questionnaire was used to collect the data, the findings were limited and depending on the respondents’ answers regarding the issue.
Does the Order of Information Affect Investors' Investment Decisions? Experimental Investigation
Authors: Aprayuda Riyadi , Misra Fauzan , Kartika Rayna
Published: January 2021

Research aims: This study examines the order of information’s effect according to the Belief Adjustment Model. In particular, this study investigates the effect of the direction of the order and the pattern of presenting information in making investment decisions.Design/Methodology/Approach: The research applied an experimental method with web-based instruments using a 2x2 factorial design between subjects, involving 65 investors.Research findings: The investors’ investment valuation who received negative to positive information sequence direction was higher than the investors who received positive to negative information direction. Furthermore, there was an order effect in the form of recency on investors who received a partial presentation pattern. Meanwhile, investors who received a simultaneous pattern did not show an order effect in their assessment. These findings underline that the simultaneous pattern could reduce the order effect, so that investors need to generalize the information as a whole to avoid this bias.Theoretical contribution/Originality: This study extends the investigation of investment decisions using a long sequence of information perspectives and more varied types of information (e.g., financial information, corporate governance, and industry sectoral information that has an impact on company conditions) in making investment decisions on the belief adjustment model.Practitioner/Policy implication: Companies must maintain the direction of the order and the presentation patterns when issuing company information to maintain the quality of investors' decisions and avoid the risk of volatility in company shares.Research limitation/Implication: Participants who joined this research were active investors but had not yet had a comprehensive experience.
Diagnosis and Treatment of Pancreatogenic Bleedings
Authors:   Avicenna Tajik State Medical University, Kurbonov К.М. , Ruziboyzoda K.R. ,   Avicenna Tajik State Medical University, Ali-Zade S.G. ,   Avicenna Tajik State Medical University
Published: January 2021

Цель. Оценить результаты оказания помощи пациентам с панкреатогенными кровотечениями. Материал и методы. Проанализированы результаты лечения 84 пациентов с панкреатогенными кровотечениями (ПК). В 73 (86,9%) случаях кровотечения были после прямых вмешательств на поджелудочной железе (n=12) и гнойно-септических осложнений острого панкреатита (ОП) (n=61). В 11 (13,1%) наблюдениях кровотечения возникли при хроническом панкреатите (ХП), осложненном ложными кистами (ЛК) поджелудочной железы. В 42 (50%) наблюдениях имело место кровотечение типа А, в 26 (31%) – типа В и в 16 (19%) – типа С. Оценивались результаты оказания помощи в зависимости от типа и тяжести кровотечения. Результаты. Консервативная терапия в 31 наблюдении из 42 при кровотечениях типа А позволила добиться стойкого гемостаза. В 12 случаях при ПК, обусловленных пенетрирующими в поджелудочную железу язвами желудка и двенадцатиперстной кишки, для достижения гемостаза эффективно использовали методику комбинированного эндоскопического гемостаза с проведением антисекреторной терапии. При наличии внутрибрюшных послеоперационных профузных кровотечений типа В и С вследствие панкреонекроза в 38 наблюдениях выполняли релапаротомию, прошивание кровоточащего сосуда с тампонированием (n=7) поджелудочной железы, санацией и дренированием брюшной полости. Отмечено 18 летальных исходов. Резекция хвоста поджелудочной железы со спленэктомией выполнена в 4 наблюдениях, в 9 случаях для достижения гемостаза при кровотечениях из ЛК ПЖ производили прошивание кровоточащего сосуда с наружным дренированием и тампонированием ЛК ПЖ (n=6), а также продольный панкреатоеюноанастомоз (n=3). Летальные исходы были отмечены в 2 наблюдениях. В 2 случаях выполняли рентгеноэндоваскулярную эмболизацию желудочно-двенадцатиперстной артерии. Осложнений и летальных исходов не отмечено. Заключение. Кровотечения, сопровождающиеся выраженными гемодинамическими нарушениями, требуют выполнения открытых оперативных вмешательств. Рентгеноэндоваскулярные методы эффективны при кровотечениях, развивающихся при остром и хроническом панкреатите и в послеоперационном периоде. Научная новизна статьи Предложено выделять три типа панкреатогенных кровотечений. Использование предложенного варианта классификации наряду с учетом тяжести кровотечения позволяет выбрать наиболее патогенетически обоснованный способ гемостаза. Продемонстрировано, что тяжелые панкреатогенные кровотечения, сопровождающиеся выраженными гемодинамическими нарушениями, требуют выполнения неотложных открытых оперативных вмешательств. Рентгеноэндоваскулярные методы являются эффективными малоинвазивными методами гемостаза артериального кровотока при кровотечениях, развивающихся на фоне острого и хронического панкреатита, а также при кровотечениях в послеоперационном периоде.
Surgical Treatment of Isolated and Multiple Duodenal Injuries
Authors:   Kharkiv National Medical University MH of Ukraine, Boyko V.V. ,   Zaytsev Institute of General and Emergency Surgery NAMS of Ukraine, Kryvoruchko I.A. ,   Kharkiv National Medical University MH of Ukraine, Riabtsev R.S. ,   Zaytsev Institute of General and Emergency Surgery NAMS of Ukraine, Dotsenko Ye.G. ,   Zaytsev Institute of General and Emergency Surgery NAMS of Ukraine, Smachylo Р.М. ,   Kharkiv National Medical University MH of Ukraine,   Zaytsev Institute of General and Emergency Surgery NAMS of Ukraine, Honcharova N.N. ,   Kharkiv National Medical University MH of Ukraine
Published: January 2021

Цель. Оценить результаты хирургического лечения пациентов, прооперированных по поводу изолированных или множественных повреждений двенадцатиперстной кишки. Материал и методы. Проведено ретроспективное двуцентровое исследование 60 пострадавших с изолированными и множественными травмами двенадцатиперстной кишки ≥ II степени согласно критериям Американской ассоциации хирургии травм (AAST), оперированных в 2006-2018 гг. Результаты. 16 (26,7%) получили закрытые травмы, 44 (73,3%) – травмы проникающего характера, из которых 35 (79,5%) – колото-резаные ранения, 5 (11 4%) – огнестрельные, 4 (9,1%) – минно-взрывные. Мужчин было 42 (70%), женщин – 18 (30%), средний возраст составил 36 [18-73] лет. Показатели RTS, ISS и APACHE II scores при поступлении составили 6 [4-8], 14 [4-25] и 14 [8-32] соответственно; 22 пострадавших (36,7%) поступили с шоком. Повреждения двенадцатиперстной кишки II степени были у 31 (51,7%), III – у 24 (40%), IV – у 3 (5%) и V – у 2 (3,3%) пострадавших. Множественные внутрибрюшные травмы были у 52 (86,7%) (1,81 ассоциированная травма на одного пациента). Первичный шов был наиболее применяемой хирургической процедурой у большинства пострадавших (76,4%), выключение двенадцатиперстной кишки из пассажа – у 13,3%, дуоденоеюностомия – у 6,7% и панкреатодуоденальная резеция – у 3,3%. Послеоперационная летальность составила 18,3%. Заключение. Травмы двенадцатиперстной кишки при ранней диагностике и своевременном хирургическом вмешательстве могут эффективно лечиться с помощью простых хирургических методов (первичный шов). Сложные травмы двенадцатиперстной кишки и те, которые связаны с повреждением соседних органов и структур, требуют более продуманной стратегии, которая включает в себя тщательный учет физиологической устойчивости пациента, тяжести травмы, степени выраженности изменений в брюшной полости и забрюшинном пространстве, а также опыта хирурга. Научная новизна статьи Дополнены научные знания о том, что травмы двенадцатиперстной кишки при ранней диагностике и своевременном хирургическом вмешательстве могут эффективно лечиться с помощью простых хирургических методов. Сложные травмы двенадцатиперстной кишки и те, которые связаны с повреждением органов и структур брюшной полости и забрюшинного пространства, требуют более продуманной стратегии, которая включает в себя тщательный учет физиологической устойчивости пациента, тяжести травмы, степени выраженности интраоперационных повреждений, а также опыта хирурга.
Efecto del aceite esencial de Chrysactinia mexicana A. Gray sobre aislados clínicos de Candida glabrata
Authors: Gallegos-García Verónica , Medina-de la Cruz Omar , Leal-Morales Carlos Alberto , Meza-Menchaca Thuluz , Guillen Larissa , Juárez-Flores Bertha Irene
Published: January 2021

El objetivo del trabajo fue evaluar el efecto del aceite esencial Chrysactinia mexicana A. Gray en aislados clínicos de C. glabrata. Se obtuvo aceite esencial por arrastre de vapor de las flores, hojas y ramas secundarias de C. mexicana. Se realizó cromatografía de gases y espectrometría de masas para conocer la composición del aceite. Se hicieron ensayos de microdilución en fase logarítmica y fase estacionaria con Saccharomyces cerevisiae y aislados clínicos de C. glabrata para determinar la Concentración Mínima Inhibitoria (CMI) en presencia del aceite esencial. Los principales compuestos del aceite esencial fueron la piperitona (29.57 %), eucaliptol (26.86 %), a-terpineol (14.65 %), delta-3-careno (12.37 %) y linalool (3.56 %). Se determinaron las CMI del aceite esencial, para las cinco cepas utilizadas en las dos fases de crecimiento, siendo menor la CMI para S. cerevisiae que para los diferentes aislados clínicos de C. glabrata. El aceite esencial de C. mexicana tiene efecto fungicida en S. cerevisiae y los aislados clínicos de C. glabrata.
Overall survival and disease control rates for operable invasive breast cancer in the era of conservative surgery; retrospective, institutional, and five-year follow-up data
Authors:   Department of General Surgery and Surgical Oncology, Clinical Hospital Center Rijeka, Rijeka, Croatia, Car-Peterko Ana , Avirović Manuela , Skočilić Iva , Valković-Zujić Petra , Belac-Lovasić Ingrid , Lovasić Franjo
Published: January 2021

Background: Following breast cancer treatment recommendations, the conservative approach is accepted and highly respected in the Clinical Hospital Center (CHC) Rijeka. However, we have found that institutional follow-up data are lacking. This retrospective analysis aims to update institutional data on survival and disease control rates. Methods: From 2011 till 2014, 915 breast cancer patients underwent surgery at CHC Rijeka, and 615 were included in this analysis. The Institutional Ethics Committee approved the analysis. Results: All patients were female, and the average age was 59 years. In the 5-year postoperative period, local, regional, and distant recurrence-free survival rates and overall survival and disease-free survival were calculated. All rates negatively correlate with a higher T and N status and a higher stage of the disease. The analysis has also demonstrated that in the pT1-3 pN0-1 subgroup, sentinel lymph node biopsy (SLNB) was not inferior to axillary lymph node dissection (ALND) in terms of locoregional control of disease and overall survival. Conclusion: Besides updating institutional data, the analysis confirmed that overall survival and locoregional control of the disease in the upfront-surgery patients are similar between pN0 and pN1 subpopulations and between pN2 and pN3, but statistically significantly different between pN0-1 and pN2-3. Currently ongoing, prospective observational multicenter clinical trial aims to translate the significance of these results into the neoadjuvant era.
Obesity and cancer
Authors:   Division of Oncology and Radiotherapy. University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia, Cmrečak Franjo , Andrašek Iva , Gregov Višnja , Beketić-Orešković Lidija
Published: January 2021

For the past several decades, we have witnessed the emergence of the obesity pandemic worldwide and, simultaneously, the increase of incidence of malignant diseases. The effects of obesity and overweight on cancer incidence, morbidity, and mortality started to be meticulously researched only recently. According to the epidemiological data analysis, the connection between obesity and increased risk of numerous cancers has been established. Estimations are that a change in lifestyle and diet can prevent 30-50% of malignant diseases. After smoking, obesity is the second largest preventable cause of cancer. Obesity affects the quality of life and increases the risk of cancer recurrence and cancer-related mortality. By reducing body mass and avoiding gaining weight during adulthood, the risk of getting cancer is lowered. Numerous studies have shown the beneficial effects of physical activity during and after cancer treatment. Obesity influences cancer development; however, the mechanisms responsible for it are still unclear. It is considered that chronic inflammation, caused by the overabundance of nutrients, increases the levels of inflammatory cytokines and immune cells. It has been discovered that adipocytes have an important endocrine role; they synthesize numerous hormones and adipocytokines, such as leptin and adiponectin. High levels of leptons and low levels of adiponectin can activate intracellular signaling pathways involving malignant cells’ development. An important part of cancer development can be attributed to insulin metabolism, insulin-like growth factors, and sex hormones.
Rare case of invasive lobular breast cancer metastasis to the endometrium
Authors:   Department of Gynecologic Oncology, University Hospital for Tumors,Sestre milosrdnice University Hospital Center, Zagreb, Croatia, Danolić Damir , Marcelić Luka , Alvir Ilija , Mamić Ivica , Šušnjar Lucija , Rendić-Miočević Zrinka , Puljiz Mario
Published: January 2021

Metastases to the female genital tract from extra-genital primary cancers are uncommon and usually occur during widespread metastatic disease. Breast cancers are the most frequent primaries, predominantly the lobular type. Here, we report a case of a 55-year-old woman with breast cancer endometrial metastasis who presented with postmenopausal vaginal bleeding. We highlight the importance of endometrial sampling to confirm the diagnosis and distinguish primary from metastatic cancer of the endometrium since the treatment and prognosis of these conditions are entirely different.
Calcifying fibrous tumor of the rectum - a case report
Authors:   Josip Juraj Strossmayer Unversity of Osijek, Faculty of Medicine, Osijek, Croatia, Pavlović Tomislav ,   Department of Radiology, St.Catherine Specialty Hospital, Zabok, Croatia, Troskot-Perić Rosana , Trtica Sanja
Published: January 2021

A calcifying fibrous tumor (CFT) is a benign tumor of unknown etiology. A calcifying fibrous tumor is rare in the intestinal tract. A calcifying fibrous tumor is characterized by hyalinized collagenous fibrous tissue, psammomatous or dystrophic calcification, and focal lymphoplasmacytic infiltrates on histology. Magnetic resonance imaging is the standard method for evaluating the lesions of the rectum, and CFTs should be considered in differentiating the rectal wall tumors. Herein, we report a case of a 68-year-old man with a rectal wall CFT.
Make Your Cake and Eat It: Refueling of Immune Fitness in AML Post Allo-HCT Using Baking Soda
Authors: Tonks Alex
Published: January 2021

Although there has been a recent renaissance in the availability of new therapeutic options for patients with acute myeloid leukemia (AML), survival rates remain low coupled with a high incidence of relapse. Enhancing T cell and immune function has become an effective therapeutic approach in hematological malignancies. However, AML cells can modulate the bone marrow microenvironment by changing extracellular nutrient and biochemical availability which can metabolically regulate immune function. Here we review the findings by Uhl et al. showing that T cell metabolism and function can be boosted by treatment with sodium bicarbonate to counteract the metabolic changes induced by lactic acid produced by leukemia cells.
Adolescent Menstrual Health Literacy in Low, Middle and High-Income Countries: A Narrative Review
Authors: Holmes Kathryn , Curry Christina , Sherry Sherry , Ferfolja Tania , Parry Kelly , Smith Caroline , Hyman Mikayla , Armour Mike
Published: January 2021

Background: Poor menstrual health literacy impacts adolescents’ quality of life and health outcomes across the world. The aim of this systematic review was to identify concerns about menstrual health literacy in low/middle (LMIC) and high-income (HIC) countries. Methods: Relevant social science and medical databases were searched for peer-reviewed papers from January 2008 to January 2020 identifying 61 relevant studies. Results: A thematic analysis of the data revealed that LMICs report detrimental impacts on adolescents in relation to menstrual hygiene and cultural issues, while in HICs, issues related to pain management and long term health outcomes were reported more frequently. Conclusions: In order to improve overall menstrual health literacy in LMICs and HICs, appropriate policies need to be developed, drawing on input from multiple stakeholders to ensure evidence-based and cost-effective practical interventions.
A Population Game Model for the Expansion of Airbnb in the City of Venice
Authors: Arbara Sophia , D'Autilia Roberto
Published: January 2021

The emergence of Airbnb along with an increase in urban tourism has intensified the pressure on urban areas while adding a new dimension in the dynamics of the housing distribution especially in historic cities. These dynamics affect both local economies and alter significantly the characteristics of urban space arising the necessity to create not only policies that foster sustainable tourism development but also to advance urban models that explore the relation between Airbnb and the traditional rental and accommodation sector. Through the case of Venice, the present study sheds light on the potential evolution of Airbnb housing in comparison to the traditional rental and homeowner market. In particular, it seeks to understand whether a potential equilibrium between these uses exists and if so, at which point in regards to this equilibrium the historic center of Venice is now. To tackle this question, methods deriving from the field of game theory and specifically evolutionary game theory are used. With the agents (players) being the housing units, the designed theoretical model explores the population dynamics of the housing units in Venice given the three options of homeownership or long-term rental (residential), short term rental over Airbnb (airbnb) or no use (vacant). The findings of our theoretical population game model are validated and discussed against a dataset describing the use patterns in the city of Venice during the past 20 years. A verification of the outcome through further case studies could eventually provide insights on future behavior of tourism pressure in historic urban areas.
Biological role and clinical significance of neuropeptides in pediatrics: peptide YY and ghrelin
Authors:   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Khavkin A.I. , Ayrumov V.A. ,   I.P.Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russian Federation, Shvedkina N.O. ,   I.P.Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russian Federation, Novikova V.P. ,   I.P.Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russian Federation
Published: January 2021

The increasing prevalence of alimentary obesity necessitates the search for its causes. In addition to eating disorders, other factors were found to affect lipid metabolism, including genetic predisposition, adipose tissue hormones, neurohormones, and digestive tract hormones regulating hunger and satiety, such as peptide YY (PYY) and ghrelin. This literature review focuses on these biologically active substances and their physiological and pathophysiological role. Key words: obesity, peptide, ghrelin
A Study on Teachers' Perceptions towards Cultural Arts Subject Using Wayang Kulit Purwa to Students of Junior High School in Solo Raya
Authors: Subiyantoro Slamet , Fadhilah Siti S
Published: January 2021

This study revealed the perception of cultural arts teachers on the local Javanese wayang kulit purwa media to instilling students’ character values through learning art and culture at junior high school levels throughout the great Solo (Solo Raya) area. There is a previous assumption that wayang kulit purwa has only been performed at general public beyond formal school institutions such as junior high schools. Meanwhile, in instilling the values of character education, the teachers indicated through the subjects taught, the results showed that they were still found to be limited to formal media. This study reflects its own specific points, this is because the teaching aids used are the Purwa puppet media. This study was carried out by applying a survey to 69 cultural arts teachers who were selected purposively in all areas of Solo Raya covering 7 (seven) regencies / municipalities. The technique applied in collecting data is through questionnaires and interview techniques. To analyze the data, an interactive model is used which includes the initial steps of data collection, data reduction, data presentation and drawing conclusions. The results showed that most cultural arts teachers had positive and negative perceptions of wayang kulit purwa if it was used as a medium of learning and planting character education for students at junior high school level. However, most of the cultural arts teachers who have had a graduate education have positive perceptions. Because wayang kulit purwa reflects moral, socio-cultural values, character education as well as patriotism
KOMPARASI PEMIKIRAN BERWICK SAYERS DAN MARY MORTIMER TENTANG SISTEM KLASIFIKASI PERPUSTAKAAN
Authors: Fadilla Nurul
Published: January 2021

Tulisan ini membahas bagaimana sistem klasifikasi perpustakaan yang baik dan bersumber dari hasil pemikiran Berwick Sayers dan Mary Mortimer, kemudian dilakukan komparasi serta dilihat kerelevansian atas hasil pemikiran tersebut. Tulisan ini menggunakan pendekatan kualitatif. Analisis dilakukan secara deksriptif komparatif. Berwick Sayers dan Mary Mortimer telah dikenal banyak memunculkan pemikiran-pemikiran dan menghasilkan karya-karya salah satunya tentang sistem klasifikasi perpustakaan. Dari hasil komparasi pemikiran yang telah dilakukan tentang sistem klasifikasi perpustakaan, terdapat empat hal perbedaan yang mendasar diantara kedua tokoh tersebut. Perbedaan tersebut terletak pada 1) Bentuk klasifikasi yang baik itu adalah yang mudah digunakan, pernyataan tersebut secara tegas diberikan oleh Mary Mortimer, karena baik versi pustakawan belum tentu baik versi pemustaka, sehingga akan berbeda hasilnya, namun yang mudah digunakan bagi pemustaka, sudah pasti baik bentuk klasifikasinya, sedangkan Berwick Sayers tidak memberikan pernyataan yang menegaskan namun hanya menjelaskan perihal klasifikasi yang baik, 2) Notasi yang sederhana vs notasi yang spesifik, 3) Memiliki tabel geografis, 4) Alfabetis vs sistematis. Dan didapat pula empat persamaan yaitu 1) Meliputi seluruh bidang ilmu pengetahuan, 2) Mampu  mengakomodasi subjek dan notasi ilmu pengetahuan yang baru, 3) Melakukan pengembangan pada ilmu pengetahuan baru, dan 4) Mempunyai suatu badan pengawas.
HUBUNGAN ANTARA SENSE OF HUMOR DAN BURNOUT PADA GURU SD DI JAKARTA TIMUR
Authors: Yudhaningrum Lupi
Published: January 2021

This study aims to determine the relationship between sense of humor with burnout on elementary school teachers in Jakarta. This research uses quantitative methods. The measuring instrument used to measure burnout is the Maslach Burnout Inventory Educators Survey (MBI-ES). Sense of humor is measured by the Multidimensional Sense of Humor Scale (MSHS) by Thorson and Powell. The statistical method used to analyze the data of this study is the Spearman rank correlation. The results showed a significance value (p) of 0.010 (p <0.05). These results indicate that the hypothesis in this study is accepted that there is a significant relationship between sense of humor with burnout on elementary school teachers in East Jakarta. A negative sign on r count indicates the two variables have a non-directional relationship.
RELIABILITAS DAN VALIDITAS KONSTRUK WORK LIFE BALANCE DI INDONESIA
Authors: Gunawan Gianti
Published: January 2021

Research on the reliability and validity of the work life balance construct is important considering that in Indonesia there is currently no instrument specifically used to measure or assess work life balance and because of the development of an understanding of the work life balance construct which always develops as a multidimensional construct. The subjects in this study were 460 employees of State-Owned Company in Bandung. The work life balance scale used in this study is an adaptation of the work life balance questionnaire developed by Gwenith G. Fisher, Carrie A. Bulger and Carlla S. Smith (in Journal of Occupational Health Psychology 2009, Vol. 14, No. 4, 441–456). In this study, the method of analysis is the confirmatory factor. The results showed that the items for the work life balance scale had SLF values ​​ranging from 0.75 to 0.912 so that all items could be said to be valid. CR value is 0.976 and VE is 0.707, which means a reliable work life balance scale. Work life balance scale is devided into two aspects, namely demands and resources. The demands aspect consists of 2 (two) sub aspects, namely work interference with personal life (PLIW) and personal life interference with work (PLIW) and. The second aspect, namely resources has 2 (two) sub aspects, namely work enhancement of personal life (WEPL) and personal life enhancement ofwork (PLEW).
BEHAVIORAL ACTIVATION (BA) UNTUK MENURUNKAN GANGGUAN DEPRESI PADA MAHASISWA UNIVERSITAS NEGERI JAKARTA
Authors: Zakiah Ernita
Published: January 2021

This study aims to examine the effect of Behavioral Activation (BA) to reduce student's depression disorders of Universitas Negeri Jakarta. Methods of data collection using observations, semi-structured interviews, and BDI measurement tools.  The measuring instrument used is the Beck Depression Inventory (BDI) made by Beck in (1976) translated by Zarina (2007).  Interference disorders need to be given an intervention, because subjects with depressive disorders tend to avoid social environment, easily feel tired, avoid or do nothing activities, almost all the time experiencing feelings of depression, easily distracted concentration, etc.
Psikoedukasi Pola Asuh Pada Ibu-ibu di Wilayah Puskesmas Keputih, Surabaya
Authors: Yolanda Candra Arintina
Published: January 2021

Intervensi psikologi ini bertujuan untuk meningkatkan pengetahuan mengenai pola asuh pada ibu-ibu Posyandu Kenanga di area Puskesmas Keputih, Surabaya, dengan memberikan Psikoedukasi Pola Asuh. Subjek intervensi ini adalah 11 orang ibu yang dipilih menggunakan teknik purposive sampling. Pengetahuan mengenai pola asuh diukur menggunakan pretest-posttest kuesioner yang dibuat oleh peneliti. Hasil dari intervensi ini adalah adanya efek positif dari Psikoedukasi Pola Asuh untuk meningkatkan pemahaman pola asuh pada ibu-ibu (Asymp. Sig (2-tailed) 0.001 < 0.05).
Morphometric and meristic analyses of Randall’s threadfin bream Nemipterus randalli Russell, 1986 along the Indian coast
Authors: Srihari Murugesan , Pradhan Suraj Kumar , Pavan-Kumar Annam , Bhushan Shashi , Nayak Binaya Bushan , Sreekanth G. B. , Abidi Zeba Jaffer
Published: January 2021

Nemipterus randalli Russell, 1986 is one of the commercially important demersal fish in Indian waters. The present study was designed to understand the morphometric and meristic variations between the stocks of N. randalli along the Indian coast. A total of 450 samples were collected from 5 maritime states during September 2018 to November 2018. A total of 19 morphometric and 9 meristic traits were extracted and subjected to statistical analyses. Factor analysis showed that morphometric characteristics like eye diameter, head length, pre-pectoral length, post-orbital length, anal fin length and caudal peduncle depth were significant in separating the stocks. Discriminant function analysis showed a high re-classification success rate of 80.43%. Kruskal-Wallis test of meristic traits revealed lack of difference between the stocks. Results indicated the presence of different phenotypic stocks along the Indian coast and therefore the need for separate management strategies for sustaining the catch of N. randalli in the future.