bluuebunny/crossref_metadata_2025 huggingface dataset:
Fractional Hartley Transform and its Inverse
Authors: Gaikwad Vasant
Published: March 2023

The Hartley transform generalizes to the fractional Hartley transform (FRHT) which gives various uses in different fields of image encryption. Unfortunately, the available literature of fractional Hartley transform is unable to provide its inversion theorem. So accordingly original function cannot retrieve directly, which restrict its applications. The intension of this paper is to propose inversion theorem of fractional Hartley transform to overcome this drawback. Moreover, some properties of fractional Hartley transform are discussed in this paper.
Sum of Squares of ‘n’ Consecutive Carol Numbers
Authors: SHANMUGANANDHAM P. , DEEPA C.
Published: March 2023

The discussion in this paper gives several theorems and lemmas on the Sums of Squares of  consecutive Carol Numbers. These theorems are proved by using the definition of carol numbers and mathematical induction method. Here the matrix form and the recursive form of sum of squares of  consecutive Carol numbers is also given. The properties of the Carol numbers are also derived.
Minimum Neighborhood Domination of Split Graph of Graphs
Authors: W ANJALINE. , MARY A.STANIS ARUL
Published: March 2023

Let  be a non-trivial simple graph. A dominating set in a graph is a set of vertices such that every vertex not in the set is adjacent to at least one vertex in the set. A subset  is a minimum neighborhood dominating set if  is a dominating set and if for every  holds. The minimum cardinality of the minimum neighborhood dominating set of a graph  is called as minimum neighborhood dominating number and it is denoted by  . A minimum neighborhood dominating set is a dominating set where the intersection of the neighborhoods of all vertices in the set is as small as possible, (i.e., ). The minimum neighborhood dominating number, denoted by , is the minimum cardinality of a minimum neighborhood dominating set. In other words, it is the smallest number of vertices needed to form a minimum neighborhood-dominating set. The concept of minimum neighborhood dominating set is related to the study of the structure and properties of graphs and is used in various fields such as computer science, operations research, and network design. A minimum neighborhood dominating set is also useful in the study of graph theory and has applications in areas such as network design and control theory. This concept is a variation of the traditional dominating set problem and adds an extra constraint on the intersection of the neighborhoods of the vertices in the set. It is also an NP-hard problem. The main aim of this paper is to study the minimum neighborhood domination number of the split graph of some of the graphs.
An Investigation of Corona Domination Number for Some Special Graphs and Jahangir Graph
Authors: Praveenkumar L. , Mahadevan G. , Sivagnanam C.
Published: March 2023

In this work,  the study of corona domination in graphs is carried over which was initially proposed by G. Mahadevan et al. Let be a simple graph. A dominating set S of a graph is said to be a corona-dominating set if every vertex in is either a pendant vertex or a support vertex. The minimum cardinality among all corona-dominating sets is called the corona-domination number and is denoted by (i.e) . In this work, the exact value of the corona domination number for some specific types of graphs are given. Also, some results on the corona domination number for some classes of graphs are obtained and the method used in this paper is a well-known number theory concept with some modification this method can also be applied to obtain the results on other domination parameters.
Some New Results on Lucky Labeling
Authors: Ashwini J. , Selvam S.Pethanachi , Gnanajothi R.B.
Published: March 2023

Czerwi’nski et al. introduced Lucky labeling in 2009 and Akbari et al and A.Nellai Murugan et al studied it further. Czerwi’nski defined Lucky Number of graph as follows: A labeling of vertices of a graph G is called a Lucky labeling if  for every pair of adjacent vertices u and v in G where . A graph G may admit any number of lucky labelings. The least integer k for which a graph G has a lucky labeling from the set 1, 2, k is the lucky number of G denoted by η(G). This paper aims to determine the lucky number of Complete graph Kn, Complete bipartite graph Km,n and Complete tripartite graph Kl,m,n. It has also been studied how the lucky number changes while adding a graph G with Kn and deleting an edge e from Kn.
Psychological Profiles Associated with Positive and Negative Risk-Taking in Adults
Authors: Fryt Joanna , Duell Natasha , Szczygieł Monika
Published: March 2023

Although risk is often considered in the context of maladaptive behaviors, risks can also be positive, allowing individuals to pursue meaningful goals in a socially accepted way. In this study, we were interested in examining psychological profiles associated with positive and negative risk-taking in adults (N = 275, ages 19–71 years) using latent profile analysis. Specifically, we examined whether distinct profiles of psychological characteristics such as future time perspective, tolerance to ambiguity, and sensitivity to reward and punishment are differentially associated with positive and negative risk-taking. Findings yielded two profiles: individuals in the first profile, characterized by lower sensitivity to punishment and higher tolerance to ambiguity, future time perspective, and sensitivity to reward, endorsed greater positive and negative risk-taking. Conversely, individuals in the second profile, characterized by heightened sensitivity to punishment and lower tolerance to ambiguity, future time perspective, and sensitivity to reward, endorsed lower positive and negative risk-taking. The study contributes to previous findings by identifying additional psychological characteristics that may be associated with both positive and negative risk-taking in adults.
Hybrid Genetic Algorithm with Directed Acyclic Graph for Enhancing Data Transmission and Reducing Energy Hole Problem
Authors: sheela Sahaya , R Prabakaran , A Arun C
Published: March 2023

Software Defined Networking (SDN) is a smart architecture which enables a network to be controlled in a centralized manner. It plays a vital role in several real-time applications and has three planes- the data plane, control plane and application plane. The architecture of SDN is simple and is inbuilt with a centralized controller at the control plane. SDN operates efficiently on Mobile Adhoc NETworks (MANET) in various environments and applications. Due to the mobility of nodes, several research issues are faced by SDN-MANET. Some of the challenges include a large overhead and less packet delivery ratio. To overcome these challenges, a Hybrid Improved Whale optimization with Particle Swarm Optimization algorithm (HIW-PSO) is proposed with Directed Acyclic Graphs (DAG) topology. This algorithm enhances the data transmission by reducing the energy hole issue. The Directed Acyclic Graphs (DAG) topology is constructed by calculating the polynomial-time for lining of all participant nodes through its edges. The proposed algorithm is evaluated for packet delivery ratio, throughput, delay, network lifetime and energy consumption. Furthermore, the performance of HIW-PSO is evaluated against other standard contemporary optimization algorithms EHO and M-LWO. As a result, the proposed method achieves an energy consumption of 35.8%, PDR of 53.2 %, a throughput of 84.8%, network lifetime of 75.4% and delay of 23.8%.
A Meta-analysis on the Impact of Intervention on Mathematics Anxiety among (Young) Adults
Authors: Ponetti Giordano , Wallymahmed Akhtar H.
Published: March 2023

Background and Aims: The construct of mathematics anxiety has received increasing attention in the past decades because of its correlation with mathematics performances, achievements, and subsequent choice of STEM majors and careers. Intervention research and reviews on the topic have been directed predominantly to school-age students, while little is known about interventions for (young) adults, and quantitative reviews are missing.
Methods: The present study aims to conduct a meta-analytic review of interventions on mathematics anxiety levels in (young) adults. Searches were conducted using the following databases: ERIC, MEDLINE, PsycINFO, SAGE, Scopus, and Web of Science. Twelve studies published in English language from the year 2000 were included in this meta-analysis. The selected studies included mathematics anxiety interventions targeted at the population aged 18 and older. Interventions ranged from one-time sessions to six months programs and were integrated into a mathematics course. The studies compared intervention effectiveness with a control condition and tested the efficacy of relaxation techniques, clinical psychological interventions, focused mathematics skills training, and improved teaching practices. The quality of the included articles was assessed, and the quantitative statistics were computed (using RevMan and the metafor package of R) under the Random Effect Model assumption.
Results: The meta-analysis showed 1) a small-to-medium, significant overall intervention effect (d = −0.31, 95% CI [-0.44, -0.19], p < 0.001), 2) a null variability of true effect sizes (τ2 = 0), and 3) consistency (negligible heterogeneity) across studies (I2 = 4%, p=0.41). Potential sources of bias that may have lowered the precision of the study are discussed.
Conclusions: This work supports the introduction of mathematics anxiety intervention in classroom practice for (young) adults. The findings are discussed in the context of other evidence and point to future research directions.
Propagule resistance of an invasive Poaceae as a trait of its invasiveness
Authors: bora leticia siman , Padial André Andrian
Published: March 2023

Biological invasions and consequent mass development of aquatic macrophytes are a major threat to aquatic environments. As a consequence, species invasiveness is becoming of great interest. Urochloa arrecta is a mass-development invasive Poaceae that has caused many impacts in freshwaters in Brazil. Studies have described its remarkable tolerance to stressful conditions, but propagules resistance to desiccation while in dispersion is unknown. Here we analyzed through a microcosm experiment U. arrecta’ small propagules regeneration after desiccation and without any sediment - thus simulating a transportation scenario. As expected, the longer the time of stress, the lower the propagule regeneration performance. Even so, the macrophyte propagules can survive up to six days off of water and any sediment. Even when the propagules seemed unviable, there was some degree of regeneration. As a consequence of results, we state that removal and transportation of U. arrecta should be controlled considering the propagule viability.
Development of introgression lines and mapping of qGW2, a novel QTL that confers grain width, in rice (Oryza sativa L.)
Authors: Zhao Xiangqiang , Xu Zuopeng , Chen YiBo , Du Yuanyue , Li Meng , Huang Benxi , Ge Yongshen , Gu Minghong , Tang Shuzhu , Liu Qiaoquan , Zhang Honggen
Published: March 2023

Rice grain size is a key determinant of both grain yield and quality. Identification of favorable alleles for use in rice breeding may help to meet the demand for increased yield. In this study, we developed a set of 210 introgression lines (ILs) by using indicavariety Huanghuazhan as the donor parent and erect-panicle japonica rice variety Wuyujing3R as the recurrent parent. A total of 133 ILs were selected for high-throughput sequencing. Using specific-locus amplified fragment (SLAF) sequencing technology, 10,103 high-quality SLAF labels evenly distributed on 12 chromosomes were obtained and selected for subsequent analysis. Using a high-density map, quantitative trait locus (QTL) mapping of grain size-related traits was performed, and a total of 38 QTLs were obtained in two environments. Furthermore, qGW2, a novel QTL that controls grain width on chromosome 2, was validated and delimited to a region of 309 kb via substitution mapping. These findings provide new genetic material and a basis for future fine mapping and cloning of favorable QTLs.
Compound drivers behind new record high temperatures and surface melt at the Antarctic Peninsula in February 2022
Authors: Gorodetskaya Irina , Durán-Alarcón Claudio , Gonzalez-Herrero Sergi , Clem Kyle , imazio paola rodriguez , Santos Christophe Leroy-Dos , Campos Diego , zou xun , Dutrievoz Niels , Rowe Penny , Wille Jonathan , Favier Vincent , Blanchet Juliette , Chyhareva Anastasiia , Cordero Raul , Park Sang-Jong , Colwell Steve , Lazzara Matthew , Carrasco Jorge , Gulisano Adriana , Krakovska Svitlana , Ralph F. Martin , Pohl Benjamin
Published: March 2023

The Antarctic Peninsula (AP) experienced a new extreme warm event and record high surface melt in February 2022, rivaling the recent temperature records from 2015 and 2020, and contributing to an alarming series of extreme warm events there. The northern/northwestern AP was directly impacted by an intense atmospheric river (AR) bringing anomalous heat and rainfall, while AR-enhanced foehn effect further warmed its northeastern side. The event was triggered by multiple large-scale atmospheric circulation patterns linking the AR formation to tropical convection anomalies and stationary Rossby waves, with anomalous Amundsen Sea low and record-breaking blocking high. The cascade of impacts culminated in widespread and intensive surface melt across the AP. The event was statistically attributed to global warming. Increasing frequency of such events can undermine the stability of the AP ice shelves, with multiple local to global impacts, including acceleration of the AP ice mass loss and changes in sensitive ecosystems.
Acupressure for sleep disorders, fatigue, depression and pruritus in hemodialysis patients: A systematic review and meta-analysis
Authors: Liu Cong , Yang Jiju , Li Hongdian , He Pengfei , Deng Yuanyuan , Dong Ao , Ma Yu , Zhang Sai , Chen Shu , Zhang Mianzhi
Published: March 2023

Background To evaluate the efficacy and safety of acupressure in treating sleep disorders, fatigue, depression and pruritus in hemodialysis patients and to provide evidence for clinical treatment.
Methods The China National Knowledge Infrastructure, Wanfang Database, China Science and Technology Journal Database, Chinese Biomedical Literature Database, PubMed, Web of Science, EMBASE and Cochrane Library databases were searched to screen randomized controlled trials of acupressure for sleep disorders, fatigue, depression and pruritus in hemodialysis patients. The search time frame was all from the establishment of the database to November 2022. RevMan 5.3 software was used for Meta-analysis.
Results A total of 14 papers involving 1150 patients were included. Meta-analysis results showed that acupressure was superior to the control group in improving sleep disorders [MD=-4.06, 95% CI (-4.59, -3.54), Z=15.17 (p<0.00001)], fatigue [MD=-1.39, 95% CI (-1.57, -1.21), Z=14.87 (p<0.00001) 1.57, -1.21), Z=14.87 (p<0.00001)], depression [MD=-7.24, 95% CI (-9.88, -4.59), Z=5.35 (p<0.00001)] and pruritus [MD=-2.94, 95% CI (-5.04, -0.85), Z=2.75 (p=0.006)]. No severe adverse event was reported during the acupressure intervention.
Conclusions Current evidence suggests that acupressure is effective and safe in treating sleep disorders, fatigue, depression, and pruritus in hemodialysis patients. However, the number of included clinical studies is small and the strength of evidence is insufficient, more high-quality, large-sample, multicenter randomized clinical trials are still needed for further validation.
Dental pulp stem cells-derived cannabidiol-pretreated micro-spheroids showed robust osteogenic potential via upregulation of WNT6
Authors: Liu Fangqi , Wu Qingqing , Liu Qianwen , Chen Bo , Liu Xintong , Pathak Janak Lal , Watanabe Nobumoto , Li Jiang
Published: March 2023

Dental pulp stem cells (DPSC)-derived 3D-aggregates/spheroids have shown robust soft/hard tissue regeneration potential. However, difficulties to control the cell number, size, and shape of DPSC-aggregates/spheroids cause cell necrosis and difficulties in homogenous seeding of aggregates/spheroids in the 3D-printed microporous bone grafts. Moreover, inducing the osteogenic potential of these aggregates/spheroids is still a challenge. This study developed cannabidiol (CBD)-pretreated, self-assembled, and injectable DPSC-derived osteogenic micro-spheroids (70 μm) that robustly promoted in situ bone regeneration. We developed micro-spheroids by seeding 250 cells/microwell in agarose gel microwells of 200 µm diameter developed using prefabricated mold and cultured with CBD for 14 days to induce osteogenic potential. In vitro study results showed that CBD did not affect the viability of DPSC but promoted osteogenic differentiation during 2D culture. In micro-spheroids, 3D cytoskeleton visualization showed better integrity and robustly higher expression of osteogenic markers and promoted in situ bone regeneration compared with DPSC. CBD-pretreated micro-spheroids showed robustly higher bone-regenerative capacity via upregulation of WNT6. Taken together, our approach of developing organoid-like injectable osteogenic micro-spheroids can be used as the effective carrier of the effect of in vitro drug treatment during in situ bone tissue engineering which eliminates the direct in vivo drug application-related adverse effects.
Deep origins of eukaryotic multicellularity revealed by the Acrasis kona genome and developmental transcriptomes
Authors: Sheikh Sanea , Fu Chengjie , Brown Matthew , Baldauf Sandra
Published: March 2023

Acrasids are large, fast-moving, omnivorous amoebae. However, under certain conditions, they can also cooperate to form multicellular fruiting bodies in a process known as aggregative multicellularity (AGM). This makes acrasids the only known example of multicellularity among the earliest branches of eukaryotes (formerly superkingdom Excavata) and thus the outgroup to all other known multicellular eukaryotes. We have sequenced the genome of Acrasis kona, along with transcriptomes from cells in pre-, mid- and post-development. We find the A. kona genome to be rich in novelty, genes acquired by horizontal transfer and, especially, multigene families. The latter include nearly half of the amoeba’s protein coding capacity, and many of these families show differential expression among life cycle stages. Development in A. kona appears to be molecularly simple, requiring substantial upregulation of only 449 genes compared to 2762 in the only other AGM model, Dictyostelium discoideum. However, unlike the dictyostelid, developing A. kona also does not appear to be starving, being instead very metabolically active and inducing neither autophagy nor increasing ubiquitin-tagged proteolysis. Thus, contrary to current expectations, starvation does not appear to be essential for AGM development. Moreover, despite the ~ 2 billion years of evolution separating the two amoebae, their development appears to employ remarkably similar pathways for signaling, motility and construction of an extracellular matrix surrounding the developing cell mass. In addition, much of this similarity is shared with the clonal multicellularity of animals. This makes the acrasid something of a “bare bones” developmental model and suggests that much of the basic tool kit for multicellular development arose very early in eukaryotic evolution.
Investigation of structural and microbial properties of samarium-doped nickel-strontium ferrite nanoparticles prepared via the sol-gel route
Authors: Bhore Rajkanya M. , Tigote Radhakrishnan M. , Kazi Subiya K. , Chavan Sanjay R. , Khobragade Rahul M. , Tiwari Girdharilal B.
Published: March 2023

Nickel and Samarium-doped strontium ferrite nanoparticles were synthesised using the sol-gel auto-combustion method. The micro-structural characteristics of the ferrite were investigated using X-ray diffraction (XRD) and field emission scanning electron microscopy (FE-SEM). The particle size was determined to be between 30 and 60 nm. The vibrating sample magnetometer (VSM) revealed a strong magnetization with paramagnetic behaviour, and the existence of all elements was verified by energy dispersive X-ray spectroscopy (EDS). According to the BET adsorption isotherm, total surface area ranges from 13.77 m2g-1 to 28.49 m2g-1. At P/Po (0.99), the total pore volume ranges from 0.02 cm3g-1 to 0.04 cm3g-1. The average pore width ranged from 3.5 nm to 6.5 nm, and the isotherm demonstrates type III with an H3 hysteresis loop. The material shows 84% thermal stability and these synthesized nanoparticles are showing activity against both Gram Positive and Gram-Negative bacterial pathogens.
Identifying the impact of Chlamydia trachomatis screening and treatment on mother-to child transmission and respiratory neonatal outcomes in Mexico
Authors: Arteaga-Troncoso Gabriel , López-Hurtado Marcela , Yescas-Buendía Gabino , Haro-Cruz María J. , Villagrana-Zesati J Roberto , Guerra-Infante Fernando M.
Published: March 2023

Unfavorable pregnancy outcomes caused by Chlamydia trachomatis (C. trachomatis), such as premature rupture of membranes, preterm birth, and low birth weight, are well known. Mother-to-child transmission can occur at the time of birth and may result in conjunctivitis and pneumonia in the newborn. We therefore evaluated to question whether just one maternal screening for Chlamydia is enough to prevent adverse pregnancy and negative neonatal outcomes. Among the 4,087 first-time gynecological-obstetric consultations granted at the National Institute of Perinatology in 2018, we selected the study population according to a case-cohort design. Antenatal Chlamydia screening and treatment interventions were performed on 628 pregnant women using COBAS® TaqMan CT. Chlamydia DNA was also detected in samples from 157 infants of these mothers. We find that C. trachomatis positivity was detected in 10.5%. The vertical transmission rates were 1.5% for thecohort of mothers with a Chlamydia-positive test and 29.7% for those with a negative test. By evaluating symptomatic neonatal infection, the hazard rate of perinatal pneumonia was 3.6 times higher in Chlamydia-positive babies than in Chlamydia-negative babies. Despite the low rate of mother-to-child transmission in women positive for Chlamydia trachomatisdetected with a nucleic acid amplification test and who received timely treatment, possible maternal reinfectionthat is not detected during pregnancy significantly increases the risk of neonatal infection with consequent perinatal pneumonia.
Mechanistic insight into sex differences in lung cancer induced by cRaf
Authors: Zhong Shen , Borlak Jürgen
Published: March 2023

Women are at greater risk of developing lung cancer (LC); yet the underlying causes are unknown. To gain insight into sex difference in LC, we investigated tumor growth in a cRaf transgenic disease model. Overexpression of the cRaf kinase induced an extraordinary 8-fold increase in tumor growth among females, and nearly 70% of the 112 differentially expressed genes (DEGs) were female specific. We identified oncogenes, oncomirs, tumor suppressors, cell cycle regulators and MAPK/EGFR signaling molecules, which prompted sex-based differences in LC, and we report a regulatory gene-network, which protected males from accelerated tumor growth. Strikingly, 41% of DEGs are targets of hormone receptors, and the majority (85%) are estrogen receptor (ER) dependent. We confirmed the role of ER in a large cohort of LC patients and validated 40% of DEGs induced by cRaf in clinical tumor samples. Together, we report a molecular circuitry that prompted gender disparities in tumor growth, and propose the development of molecular targeted therapies by jointly blocking ER, CDK1 and arginase 2 activity in LC.
Impacts of resection level and baseline deformity features on upper lumbar pedicle subtraction osteotomy closure ratio in ankylosing spondylitis-related thoracolumbar kyphosis
Authors: Chen Xu , Qian Bang-ping , Qiu Yong , Yu Yang , Wang Bin
Published: March 2023

Background: Pedicle subtraction osteotomy (PSO) is an unique technique widely applied in the correction of thoracolumbar kyphosis arise from ankylosing spondylitis (AS). During the osteotomy closure procedure, both the upper part of the osteotomized vertebra and the lower part of that contributed to the spinal realignment jointly. However, the relative proportion of truncal and pelvic sagittal correction which occurs with the closure of PSO has not been detailed described in AS. This study aims to investigate whether the upper lumbar osteotomy level and baseline deformity characteristics impact the distribution of global correction.
Methods: 73 AS patients who underwent single-level lumbar PSO were reviewed. Radiographic parameters included sagittal vertical axis (SVA), spino-sacral angle (SSA), global kyphosis (GK), spinal tilt (ST) and T1 pelvic angle (TPA), thoracic kyphosis (TK), lumbar lordosis (LL), pedicle subtraction angle (PSA), osteotomized vertebra angle (OVA), pelvic incidence (PI), pelvic tilt (PT), and sacral slope (SS). The truncal and pelvic closures were calculated by the change of superior or inferior endplate angle of the osteotomized vertebra. Besides, in accordance with Diebo’s project, all patients were divided into three groups based on the ratio of osteotomy closure (ROC). The impact of preoperative radiographic parameters and upper lumbar PSO level on the truncal versus pelvic closures were also investigated.
Results: No significant difference between ROC and osteotomy level was observed (P=0.155>0.05). Furthermore, there were significant differences in SVA (P<0.001), PI (P<0.001), PT (P<0.001) and ST (P<0.001) among three groups. Preoperative SVA (r=0.581, P<0.001) was positively correlated with ROC while the PI (r=-0.510, P<0.001), PT (r=-0.547, P<0.001) and ST (r=-0.517, P<0.001) were negatively correlated with ROC. Significant improvement of all the spinopelvic parameters except TK and PI were noted postoperatively. The correction of SVA (r=0.692, P<0.001) and ST (r=0.629, P<0.001) was positively correlated with ROC, whereas the variation of PT (r=-0.570, P<0.001) and SS (r=-0.461, P<0.001) was negatively correlated with ROC.
Conclusion: The osteotomy level is not the driver in the ratio of osteotomy closure but the baseline deformity features. Specifically, AS patients with preoperative larger PT realized a proportionally greater pelvic closure (improvement of pelvic retroversion) and less correction of SVA. Additionally, it’s important to get more pelvic closure as much as possible when closing the osteotomy gap for AS patients with higher PI.
Fully Data-driven non-ergodic ground-motion prediction models for low to moderate seismicity areas: using RESIF-RAP, ESM, RESORCE and NGA-West 2 data.
Authors: TANI Fayçal CHAIBEDDRA , Derras Boumediene
Published: March 2023

The aim of this work is to develop a fully non-ergodic ground motion prediction model (FNE-GMPM) that provides functional forms (ffs) for each of the world's 13 regions. The ffs are derived from machine learning of a given dataset drawn from four databases: namely RESIF-RAP, ESM, RESORCE and NGA-West2. The machine learning is performed by the neural network approach whose explanatory parameters are the moment magnitude (MW), Joyner-Boore distance RJB, average shear wave velocity in the first 30 m VS30, nature of VS30: (measured or estimated) and the focal Depth. The model thus established estimates the ground motion intensity measures (GMIMs). These GMIMs are represented by the peak ground acceleration and the peak ground velocity PGA and PGV respectively, as well as 5 as well as the 13-period acceleration pseudo-spectra from 0.04 to 4.00 s (PSA) for a damping of 5%. The 13 regions subject of this study are distinguished by their epistemic uncertainties. The aleatory variability is considered as heteroscedastic depending on the MW and the RJB. The consideration of the non-ergodicity of the heteroscedasticity and using the machine learning approach leads to a significant reduction of the aleatory variability. This work makes it possible to have strong motions for regions with low and moderate seismicity, such as metropolitan France.
A Comparative Study in Elective Repair of Large Incisional Hernia using On-lay Mesh Versus Sub-lay Mesh A Meta-Analysis
Authors: Hassan Basma Hussein Abdelaziz , Kamel Kirollos Adel Louiz , Awad Philobater Bahgat Adly , shayeb Bassem Helmy El , Fawzi Fawzi Salah , Maaty Sameh Abdallah
Published: March 2023

Background: Ventral abdominal wall incisional hernia is defined as a defect in the musculo-fascial layers of the abdominal wall in the region of postoperative scar. There is a slight increase in the incidence of incisional hernia in the female gender. The higher percentage of incisional hernia in females might be due to laxity of abdominal wall muscles after multiple pregnancies and also increased incidence of obesity in females.
Objective: To assess incisional hernia repair using two different techniques: on-lay mesh and sub-lay mesh, as regards operative time, postoperative recurrence, wound infection, seroma, hematoma and flap necrosis.
Patients and Methods: The Pubmed, web of science and Scopus were searched on 15 March, 2022. The keywords incisional hernia, sub-lay mesh on-lay mesh, retromuscular mesh, polypropylene.
Results and Conclusion: According to our results, there is a statistical difference between onlay and sublay regarding intra-operative time as sublay mesh is more time consuming. Regarding post-operative complications there is no statistical difference in recurrence, seroma, hematoma, flap necrosis and infection but there is a statistical difference regarding in hospital stay as patients with sublay repair stays less than onlay.
Is soluble urokinase plasminogen activator receptor levels still a prognostic biomarker of COVID-19 in the Omicron era?
Authors: Holub Michal , Arientová Simona , Matúšková Kateřina , Bartoš Oldřich
Published: March 2023

The authors have requested that this preprint be removed from Research Square.
Switching of Interfaces and Self-optimization of weights using Backpropagation ANN in WHN Enviornment
Authors: Rani Monika
Published: March 2023

In today’s scenario, mobile communication is facing a healthy competition due to different networks, interfaces, channels, and many more available in wireless heterogeneous environment. The problem arises when customers/users get the availability of many interfaces at the same time. At that time users need an intelligent or smart mechanism to connect them to the best services according to their requirements/preferences. Interface management manages available interfaces and connects the user with the best. In this paper, Interface management with Artificial Neural Network (ANN) allows the smart use of different radio accesses/interfaces. The selection is made with different parameters of different networks. This paper proposed a backpropagation neural network that is used for the switching in between different networks-3G, WLAN, 4G and 5G. The different parameters of a network are used as the selection parameters with assigning proper weights. Weights are initialized with fuzzy AHP and optimized with Back Propagation Neural Network (BPNN). The target value and the actual value is compared and their difference used as the adjusting value for the weights to get the optimum value. The backpropagation is used to train the network. The comparison among the projected algorithm and the existing algorithm shows the valuablity of the new method and the best connectivity of the network.
Therapeutic Target Identification in Pancreatic Ductal Adenocarcinoma: A Comprehensive In-Silico Study employing WGCNA and Trader
Authors: Yavari Parvin , Masoudi-Sobhanzadeh Yosef , Roointan Amir
Published: March 2023

Pancreatic ductal adenocarcinoma (PDAC) is recognized as a highly aggressive fatal disease accounting for more than 90% of all pancreatic malignancies. Considering the limited effective treatment options and its low survival rate, studying PDAC's underlying mechanisms is of utmost importance. The present study focused on investigating PDAC expression data using WGCNA and Trader algorithms to shed light on the underlying mechanisms and identify the most reliable therapeutic candidates in PDAC. After analyzing a recently generated PDAC dataset (GSE132956), the obtained differentially expressed genes (DEGs) were subjected to different exploration steps. WGCNA was applied to cluster the co-expressed DEGs and found the disease's most correlated module and genes. The trader algorithm was utilized to analyze the constructed network of DEGs in STRING and identified the top 30 DEGs whose removal causes a maximum number of separate sub-networks. Hub genes were selected considering the lists of top identified nodes by the two algorithms. "Signaling by Rho GTPases," "Signaling by receptor tyrosine kinases," and "immune system" were top enriched gene ontology terms for the DEGs in the PDAC most correlated module and nine hub genes, including FYN, MAPK3, CDK2, SNRPG, GNAQ, PAK1, LPCAT4, MAP1LC3B, and FBN1 were identified by considering the top spotted DEGs by two algorithms. The findings provided evidence about the involvement of some pathways in the pathogenesis of PDAC and suggested several hub genes as therapeutic candidates via a comprehensive approach analyzing both the co-expression and PPI networks of DEGs in this cancer.
Evaluation the Impact of Chlorination on Development of Chlorine and Antibiotic Resistant Bacterial Isolates in Public Swimming Pools
Authors: Najmuldeen Hastyar Hama Rashid , Razaq Chawan Hazhar
Published: March 2023

Water is essential for daily life activities; it also serves as a medium for transporting numerous waterborne diseases. This study investigated the bacteriological safety of water in swimming pools in Sulaymaniyah city, Iraq. For this purpose, during summer time (August to September, 2021), sixty-seven water samples were collected from eight indoor public swimming pools. The physicochemical parameters were determined and a bacteriological assessment was done using Most Probable Number test. Then, the diversity of microbial communities was determined using Vitek 2 compact and 16S rRNA. In addition, chlorine resistance test and biofilm formation were quantified using microdilution technique and crystal violet staining method, respectively. Moreover, Kirby- Bauer disk diffusion technique was used to test antimicrobial susceptibility.
Variable results of physicochemical analysis were recorded for each of the temperature, pH, and free chlorine ranged between (25.81±1.16 to 28.69±1.03 °C), (7.02±0.24 to 7.46±0.31), (0.12±0.05 to 1.38±1.24 mg L-1), respectively. MPN negative results showed that 80% of water samples was contaminated by non-lactose fermenter bacteria, including Enterobacter cloacae 57.61%, Pseudomonas spp. 16.96% and other major opportunistic pathogens 25.43%. The rate of contamination was strongly correlated with the sources of water used for swimming pool and free chlorine concentrations in the pools. Results of chlorine resistance test revealed variation among all isolated bacteria (1.25 to 5 mg L-1). Moreover, the correlation between different chlorine concentrations with the growth and biofilm formation was exhibited linear negative correlation. Most importantly, strong positive linear correlation was found between bacterial growth and the degree of biofilm formation (r=0.90 to 0.98), also variation in antibiogram profiles were recorded against 15 antibiotics used in this study. It can be concluded that most of the studied swimming pools are heavily contaminated by chlorine and antibiotic resistance waterborne pathogens. Therefore, continuous monitoring and use of maximum permissible chlorine disinfectant is highly recommended.
Quantum Dot Energy Levels in Hybrid Monolayer-AA Stacked Bilayer Graphene
Authors: Belouad Abdelhadi , Kamal Abdellatif , Choubabia El Bouâzzaoui , Houçaa Rachid , Bouziania Mohammed El
Published: March 2023

We investigate the energy spectrum of two types of hybrid system geometries: a circular quantumdot of single layer graphene encircled by an infinite sheet of AA-stacked bilayer graphene (i) and (ii) the circular quantum dot of AA-stacked bilayer graphene encircled by an infinite sheet of single-layergraphene. We establish analytical findings for the related energy levels and wave functions using thecontinuum model and the zigzag boundary conditions at the monolayer graphene - bilayer monolayerinterface. We analyze the effects of perpendicular magnetic fields, quantum dot radius, and electricalfields on the two types of hybrid systems. We examine the possible applications of such a hybridsystem and contrast our findings with earlier published research.
PACS numbers: 81.05.ue, 81.07.Ta, 73.22.Pr
Identification of two putative novel deltapartitiviruses and an enamovirus in coriander transcriptomes
Authors: Sidharthan V Kavi , Diksha Damini , Singh Ravindra , Choudhary Sharda , Naika Mahantesha B. N. , Baranwal V.K.
Published: March 2023

Coriander is a herbaceous spice and condiment crop also known for its medicinal properties. The present study identified two putative novel deltapartitiviruses and an enamovirus tentatively named as Coriandrum sativum deltapartitivirus 1, 2 (CsDPV1, 2) and Coriandrum sativum enamovirus (CsEV) in the publicly available transcriptome-assembled contigs derived from coriander grown in India. CsDPV1 and 2 contained tripartite and bipartite genomes, respectively with each genome segment encoding for a single ORF. CsEV contained five ORFs encoding for proteins P0, P1, P1–2, P3 and P3–5. Phylogenetic analysis revealed three distinct subgroups of deltapartitiviruses wherein CsDPV1 and 2 grouped in subgroup 3 and 1, respectively while CsEV formed a distinct sub-clade within enamoviruses. Further, presence of CsDPV2 in fruit samples of one of the cultivars from where the virus was identified was validated through RT-PCR assay and Sanger sequencing. The study highlights the need for further studies on understanding the importance and biological properties of identified novel viruses.
Comparison between Theory and Experiment for the Dry Density and Shear Stress Variations with the different Depths (groundwater level variations)
Authors: Doan Thy Truc
Published: March 2023

Comparison between Theory (Numerical simulation by the PLAXIS 3D – Finite element method) and Experiment measurement by the Viet Nam Standard “TCVN 4195:2012; TCVN 4199:1995” for the Dry Density and Shear Stress Variations with the different Depths (groundwater level variations) were shown clearly with the particular process. Results show the Dry unit weight (density) increases gradually with the increase of different depths. The maximum deviation of the dry unit weight (dry density) and Shear Stress according to the constant loading (P) at the different depths, which included in the dry density (γk) value of 16.26 kN/m2 and shear stress (τmax) 72.7 kN/m2 at 4.3m; whereas shear stress (τmax) 41.6 kN/m2; 27.1 kN/m2; 91.8 kN/m2; 98.2 kN/m2; 82.9 kN/m2 at 7.0m; 18.0m; 27.0m; 30.3m, and 39.6m; respectively. Results show the small deviation together, but some values presented changing remarkably. So research results enough reliable reference in the geotechnical engineering and researchers in the future.
Mutational analysis of ribosomal DNA and maturation-scheme analysis of ribosomal RNA in A. thaliana
Authors:   , Shanmugam Thiruvenkadam
Published: March 2023

Ribosome biogenesis is a fundamental cellular process beginning with long precursor rRNA transcription from multi-copies of repetitive 45S ribosomal DNAs. At the subunit level, the primary pre-rRNA transcript encapsuled in 90S protein-RNA complex undergoes decisive splitting in two chief ways for further maturation into large (LSU) and small (SSU) ribosomal subunit. The usage of specific rDNA copies from defined chromosomes and their selective role during growth and development have been a topic of interest owing to its contribution to specialized ribosome theory which proposes non-monolithic functions for ribosomes and thereby their mRNA translation potential. Dual-guide CRISPR/Cas9 mediated disruption of rDNA regions resulted in stable disruption of up to 2.5% and 5% of all rDNA copies in hetero- and homozygous (ploop KD) conditions, respectively. At the RNA level, the mutation excised a critical structural element, P-loop on the LSU 25S rRNA. Mutation caused a dosage dependent defect with homozygosity leading to severe developmental defects through vegetative and reproductive growth phases which is manifested in their proteome by means of disregulation through both increase and decrease of several gene ontological categories of proteins in mutants. Interestingly, the mutation on chromosome 4 triggered dosage compensation through rRNA expression from chromosome 2 further compounded by ectopic rRNA biogenesis defects. The mutated copies however are not incorporated in the translating ribosomes and as a direct or indirect consequence led to elevated basal autophagic levels in the mutants. The primary 35S transcript is known to undergo two modes of initial cleavages at the pre-rRNA level that aid in their subsequent maturation. Root cell culture (RCC) studies shows that these cells contain a novel ITS2-first cleaved precursor even under control growth conditions, P-C2 adding a third maturation means for the 35S pre-rRNA. This maturation path is further known to be triggered under elevated growth temperature forming a novel adaptive response in Arabidopsis and two other crop plants, tomato, and rice. Taken together, the pulse-chase labeling analysis of control and stressed tissues uncovers the fine-tuned pre-rRNA schematics with crossovers between multiple maturation paths.
Ripening and Storage Characteristics of the ‘Alcobaca’ Ripening Mutant in Tomato
Authors: Mutschler Martha A.
Published: March 2023

Storability, ripening, and fruit characteristics were studied in fruit of tomato (Lycopersicon esculentum Mill.) from plants heterozygous or homozygous for alc. Ripe fruit from heterozygotes showed a 78% increase in storability compared to ‘Rutgers’. Full ripe fruit of the homozygous recessive showed over 300% increase in storability, with a mean storage life of 40 days. Increased storability is not associated with initial fruit Firmness, but is accompanied by a decrease in the rate of fruit softening during storage of the fully ripe fruit. This trait does not affect pH, soluble solids, or the time required for development from flowering to mature-green fruit. The rate of further ripening is decreased. The degree of ripeness obtained by the mutant fruit is dependent on its ripeness when the fruit is picked. Mutant fruit will not fully ripen off the vine unless picked when the fruit is already at the late streak to light color stage. Ethylene production is reduced in detached, mature-green ‘Alcobaca’ fruit to 25% of that observed in ‘Rutgers’. A climacteric pattern of ethylene and CO2 production was not observed in single, detached fruit of ‘Alcobaca’ or other alc lines. The highest ethylene production detected externally was observed in the first (day one) reading of alc fruit, regardless of maturity of fruit when picked. Afterwards, ethylene production decreased to 2.5 to 3 μl·kg−1hr−1. The stage of ripeness at harvest affects the level of ethylene production of detached fruit. The maximum day-one ethylene readings were obtained from fruit harvested at the turning (40% color) stage. The rise in ethylene production during ripening also was detected in internal gas samples.
A Comparison of Controlled-release and Certain Soluble N Fertilizers on Yield and Maturity in Spring-grown Head Lettuce
Authors: Pew W. D. , Gardner B. R. , Bessey P. M.
Published: March 2023

Comparisons were made between urea, NH4NO3, (NH4)2SO4 and several controlled-release N (CRN) fertilizers on spring-grown lettuce (Lactuca sativa L.). In 1980 and 1981, single applications of CRN fertilizers produced high yields of excellent quality lettuce. In 1980, the largest yield with the most 2-dozen and fewest 2½-dozen size heads (24 and 30 heads/carton, respectively) came from lettuce receiving methylene urea (MU) F2950 at 168 kg N/ha preplant plus 84 kg N/ha as urea at folding stage. However, the yields from lettuce fertilized with this combination were not significantly different from those of lettuce fertilized with a single application of sulfur-coated urea (SCU) F9999 at either 252 kg N/ha preplant or 168 kg N/ha at thinning stage. Lettuce fertilized with urea applied at 168 kg N/ha preplant produced relatively low yields. Lettuce fertilized with urea at 168 kg N/ha in 3 applications of 56 kg N/ha each produced significantly higher yields than when the crop received urea at 168 kg N/ha preplant, but the extra applications were costly and time consuming. In 1981, lettuce fertilized with CRN sources at 224 kg N/ha preplant was earlier maturing than when fertilized with any common soluble N material at the same rate. The data show that CRN fertilizers could be helpful in reducing fertilizer application costs and keeping crop production profitable.
Effects of Rootstock and Scion Chilling during Rest on Resumption of Growth in Apple and Peach
Authors: Young Eric , Werner Dennis J.
Published: March 2023

One-year-old nursery trees of ‘Starkspur Supreme Delicious’ apple (Malus domestica Borkh.) on MM 106, M 7a, and M 9 rootstocks and ‘Redhaven’ peach [Prunus persica (L.) Batsch] on Lovell and Nemaguard seedling rootstocks were subjected to all combinations of nonchilled, partly chilled, and fully chilled rootstocks and scions, followed by forcing in a greenhouse. Budbreak and new shoot growth were increased significantly in apple by increased scion and rootstock chilling with a significant interaction between treatment effects. New root growth was increased significantly by increased rootstock chilling, and decreased by scion chilling. Budbreak and new shoot growth in peach were increased significantly by increased scion chilling and decreased by rootstock chilling, also with a significant treatment interaction. Scions on M 9 apple rootstock had significantly less budbreak and new shoot growth, and M 7a had significantly more root growth over all the chilling treatments. There was no rootstock effect in the peach trees. Possible explanations are discussed for the rootstock chilling effect in apple and the differences in apple and peach responses to chilling treatments.
Utilização de metodologia da problematização no desenvolvimento de uma ação educativa em saúde com uso de óleos essenciais e massagem
Authors: PIRES JUNIOR Ideon Alves , GOMES Ana Júlia Ferreira , SEGATO Davi Ferreira , FERNANDES Mônica Manzi , CAMPOS Maria Antonia , VITAL Isabella Azevedo , TIBURCIO Arynne Gabrielle , FERNANDES Carla Martins , RAMOS Gabriela Siqueira Araujo , VICTOR Sirlene Aparecida Borges , BARBOSA Deriely Lazara , LUCIANO Raphaelly Cristiny Bessa , SILVA Patrícia Costa dos Santos da
Published: March 2023

O emprego de metodologias ativas no ensino superior na área de saúde possibilita que os estudantes alcancem maior protagonismo no desenvolvimento de ações em saúde. Nesse contexto, este estudo objetivou relatar a experiência do uso da metodologia da Problematização com apoio do Arco de Maguerez no curso de graduação em Enfermagem. A experiência se deu com 12 alunos de uma instituição de ensino superior pública. No retorno às aulas presenciais, foram realizadas as cinco etapas do Arco de Maguerez: 1. Observação da realidade; 2. Pontos-chave; 3. Teorização; 4. Hipóteses de solução; 5. Aplicação à realidade.  A vivência resultou no desenvolvimento de uma ação educativa intitulada “Desatando nós”. Tal ação educativa focou na integralidade da assistência e agregou a todos envolvidos conhecimentos de métodos alternativos para a promoção e para a prevenção de agravos da saúde mental e física por meio do uso dos óleos essenciais e da massagem relaxante.