bluuebunny/crossref_metadata_2025 huggingface dataset:
Adult Attachment and Extradyadic Involvement in Dating Relationships: The Mediating Role of Commitment
Authors:   Faculty of Psychology and Education Sciences, University of Coimbra, Coimbra, Portugal, Martins A. , Narciso I. ,   Faculty of Psychology, University of Lisbon, Lisbon, Portugal, Canavarro M. C. ,   Faculty of Psychology and Education Sciences, University of Coimbra, Coimbra, Portugal, Pereira M. ,   Faculty of Psychology and Education Sciences, University of Coimbra, Coimbra, Portugal
Published: November 2020

Objective: The aim of this study was to assess whether the association between attachment representations, attitudes toward infidelity, interest in alternatives and sexual and emotional extradyadic involvement (EDI), both face-to-face and online, was mediated by the level of commitment in the relationship. Design and Method: The sample of this cross-sectional study consisted of 628 participants (201 men and 427 women), with a mean age of 23.36 years (SD = 3.91), all of whom reported being in an exclusive dating relationship for an average of 34 months. Participants completed the following self-report questionnaires: Extradyadic Behaviors Inventory, Attitudes toward Infidelity Scale, Experience of Close Relationships – Short Form, and Investment Model Scale. Results: Avoidant attachment was significantly associated with more positive attitudes toward infidelity, greater interest in alternatives, and all forms of EDI. Attachment-related anxiety was only associated with emotional EDI. The association between attachment-related avoidance and more favorable attitudes toward infidelity, greater interest in alternatives and both face-to-face and online EDI was mediated by low levels of commitment. No mediating effects were found for attachment-related anxiety. Conclusions: Avoidantly attached individuals indicated greater interest in alternatives and propensity to engage in EDI, especially when the levels of commitment in the relationship were low. These results are consistent with the literature suggesting that avoidant individuals engage in extradyadic behaviors as a way to meet their desires of independency. Commitment emerges as a relevant variable clarifying the involvement in extradyadic behaviors that may compromise the relational well-being.
Sleep Related Painful Erections due to Benzodiazepines
Authors:   University Hospitals Leuven, Leuven, Belgium, Ward S. , Moris L. ,   University Hospitals Leuven, Leuven, Belgium, Albersen M. ,   University Hospitals Leuven, Leuven, Belgium
Published: November 2020

Objective: To describe a case report of sleep related painful erection (SRPE) and review of the literature. Design and Method: We describe our case report and present a comprehensive review of the literature using Pubmed and Medline. Keywords used: sleep-related erection, painful erection, drugs. A 64 year old patient consulted our outpatient clinic with symptoms of erectile dysfunction, history of Peyronie’s disease and SRPE. The symptoms of SRPE started a year ago, at the same time he started taking benzodiazepines due to insomnia. After careful examination we advised to stop this medication. Re-evaluation after 10 days showed resolution of the symptoms with total disappearance of the SRPE. Results: SRPE is a rare sleeping disorder characterized by recurrent, painful penile erections occurring when awakening from REM sleep, while erections are painless during wakefulness. The repeated SRPE-related awakenings lead to REM sleep deprivation, and insomnia with accompanying daytime exhaustion, stress and irritability. Polysomnographic monitoring shows that the SPRE are associated with awakening in REM sleep, and demonstrates a disturbance of sleep stability, an increase in arousals, and instability in the erections which last beyond REM sleep. Unfortunately the pathophysiology of SRPE remains unknown. Previous association with obstructive sleep apnea syndrome therapy (OSAS) is described. It should be noted that the rarity of the published observations probably does not reflect the actual prevalence of the disorder. Conclusions: Patients with SPRE taking benzodiazepines should be counseled to stop this medication.
Alei II Technique: Minimally Invasive Technique for the Correction of Penile Curvature without Circumcision
Authors:   Department of Surgery, Sapienza University of Rome, Rome, Italy, Letizia P. , Alei G. ,   Department of Surgery, Sapienza University of Rome, Rome, Italy, Rossi A. ,   Department of Urology, Sapienza University of Rome, Rome, Italy
Published: November 2020

Objective: We describe a new surgical technique for the treatment of penile curvature. In 2012, we developed a new surgical technique for the correction of congenital and acquired penile curvature without circumcision called “track” corporoplasty or Alei II technique Design and Method: For the penile ventral curvature repair an infrapubic transverse dorsal incision is made to correct a ventral curvature or when removing or cutting the plaque in Peyronie’s disease A single 0 non-absorbable synthetic multifilament suture is placed in order to perform a special placation on two parallel lines and therefore called “track”. Laterally to the corporoplasty described, two corporoplasties should be performed along the line that goes from the dorsal neurovascular bundle to the lateral end of the corpus cavernosus at 30° and 60° on the penile sagittal plane. The two corporoplasties should measure 50% at 30° and 25% at 60. Results: Mean age was 43 years for patients with Peyronie’s disease and 31 years for patients with congenital penile deviation. The mean follow-up period was 36 months. No major complications, no circumcision, overall satisfaction 98%. Intraoperative correction of the curvature was achieved in 100%, significant relapse occurred in 2%. Conclusions: This original technique is associated with low morbidity, low recurrence rate and excellent aesthetic results.
The Effects of Porn & Sex Addiction on Partners
Authors:   Argaman Institue, Tel Aviv, Israel, Argaman R.
Published: November 2020

Objective: Various social perceptions related to porn, legitimate it and view it as victimless sexual activity. In contrast to this line of thinking, there is a growing data about the damages of porn & sex addiction, not only to the addict, but also to its partner, children and family, intimate & sexual relationship. Design and Method: Much attention focuses on the addict, but less on the spouse, the trauma they are facing, and the healing process, they need to go through. In the years, I work with sex addicts and their partners I met a lot of pain and suffering the partners bring, sometimes for many years, usually done in private with little social support. The aim of this presentation is to explore the ways sexual compulsive behavior impact the partner and the relationship, using different models and case studies. Results: Through the presentation, I will present recommendation for therapy and support to spouses. Conclusions: When working with people who suffer from porn / sex addiction, there must be a special consideration for the spouse, as an integral part of treatment.
Sexual Communication Through 5 Senses and Sexual Sentence Stems
Authors:   Private Practice, NYC ( NY STATE ) and Hoboken ( NJ State ), USA, Rusetskaya N.
Published: November 2020

Objective: AIM: The primary goal of this paper is to examine further the relationship between sexual communication and sexual satisfaction .This research contributes to the clinical sexology literature on this topic in three ways. First, it investigates the relationship between sexual communication and sexual satisfaction using qualitative analysis from several case studies. Second, it introduces a treatment tool, Sexual Sentence Stems (SSS), which can be utilized for working with couples and individuals to improve their sexual communication skills. Finally, it applies this tool with several diverse couples in sex therapy and evaluates its effectiveness.
Sexuality of 26 - 36-Year-Old Lithuanian Healthy and Type-1 Diabetic Males (Comparison with Older than 40 Years Men Sexuality of 8 European Countries)
Authors:   Lihuanian University Of Health Sciences Institute Of Endocrinology, Kaunas, Lithuania, Matulevicius V. , Banisauskaite I. ,   Lihuanian University Of Health Sciences Institute Of Endocrinology, Kaunas, Lithuania, Matuleviciute I. ,   Lihuanian University Of Health Sciences Institute Of Endocrinology, Kaunas, Lithuania, Jureviciute J. ,   Lihuanian University Of Health Sciences Institute Of Endocrinology, Kaunas, Lithuania, Kurakovas T. ,   Lihuanian University Of Health Sciences Institute Of Endocrinology, Kaunas, Lithuania, Ostrauskas R. ,   Lihuanian University Of Health Sciences Institute Of Endocrinology, Kaunas, Lithuania, Verkauskiene R. ,   Lihuanian University Of Health Sciences Institute Of Endocrinology, Kaunas, Lithuania, Urbanavicius V. ,   Faculty Of Medicine Endocrinology Center, Vilnius University, Vilnius, Lithuania
Published: November 2020

Objective: To determine the relation of the European Male Ageing Study (EMAS) Sexual function questionnaire (SFQ) parameters in the groups of healthy (H) and type 1 diabetic (T1D) males and in groups of different ages and different centers of EMAS. Design and Method: The evaluation of EMAS SFQ of 204 persons: 82 H and 122 T1D patients was performed. The answers to the questions characterizing various domains of sexual activity were analyzed. Results: Results. Eight sexual parameters were counted. The ratio of H males (%) /40 - 49-year-old EMAS males (%) was above 1, except the frequency of erectile dysfunction which is very low in the group of H males and extremely high in the group of T1D males. The results were similar when the 50 - 59-year-old EMAS group was taken in comparison to H males. The H males group shows even more clear predominance while T1D males are similar to 50 - 59-year-old EMAS males. Comparing the results of H males and EMAS males from various centers the rarity of H erectile dysfunction and higher frequency of masturbation become apparent. Other parameters do not show difference in comparison to EMAS centers. Conclusions: Conclusions. The sexuality of H males is above the one of EMAS 40 - 49-year-old males, while the sexuality of T1D males is similar to the sexuality of EMAS 50 - 59-year-old males. The erectile dysfunction is rare and the frequency of masturbation is higher when H males are compared to the various ages EMAS males from different centers.
Could Testosterone Undecanoate in Hypogonadal Patients Improve Anemia, Inflammation, and Cardiovascular Risk Factor? An Observational, 54-Week Cummulative Registrry Study
Authors:   Chonbuk National University Hospital, Jeonju, South Korea, Park J. , Lee S. ,   Samsung Medical Center, Sungkyunkwan University, Seoul, South Korea, Yang S. ,   Konkuk Uinversity School of Medicine, Chungju, South Korea, Kim J. ,   Chonbuk National University Hospital, Jeonju, South Korea, Shin Y. ,   Chonbuk National University Hospital, Jeonju, South Korea
Published: November 2020

Objective: The aim of this study was to investigate if testosterone undecanoate in patients with hypogonadism attenuates anemia and the risk for cardiovascular disease. Design and Method: A registry study consisted of 58 participants with subnormal total testosterone level (<2.35 ng/ml) and at least mild symptoms of testosterone deficiency. All the patients were injected with 1,000 mg of testosterone undecanoate on initial visit, followed by injection at 6, 18, 30, 42 and 54 weeks. Serum hormones, Hb, Hct, anemia and inflammation relating factors, lipid profiles, whole blood viscosity and anthropometry were measured. Results: Total testosterone (from 1.87 ± 1.09 to 5.52 ± 1.92 ng/ml, p <0.001) and free testosterone (p <0.001) were restored by testosterone undecanoate therapy. Hb and Hct significantly increased after testosterone undecanoate therapy by an average of 2.46 g/dl (p <0.001) and 3.03% (p <0.001), respectively. Prevalence of anemia (from 29.6 to 10.0%) and total cholesterol (p = 0.002), hs-CRP (p <0.001), ESR (p <0.001) significantly decreased (p <0.001) and patients with anemia showed a significant increase in erythropoietin (p = 0.047) after testosterone undecanoate therapy. Higher whole blood viscosity and increased Hct were observed until 54 weeks compared with baseline, however whole blood viscosity and Hct stabilized after 18 weeks. Conclusions: 54-week testosterone undecanoate decreased the prevalence of anemia and components of metabolic syndrome. A longer duration testosterone undecanoate therapy of more than 18 weeks may be effective and safe in reducing the blood viscosity and improving anemia in the patients with hypogonadism
Demand for Sexual Counselling from Patients with Acute Coronary Syndrome
Authors:   Complejo Asistencial Universitario de Palencia - Department of Accident and Department, Palencia, Spain, Domínguez E. , Villaizán P. L. ,   Complejo Asistencial Universitario de Palencia - Department of Accident and Department, Palencia, Spain, Cabello F. ,   Instituto Andaluz de Sexología Y Psicología - Department of Sexology, Málaga, Spain, Del Río J. ,   Instituto Andaluz de Sexología Y Psicología - Department of Investigation, Málaga; Universidad de Cádiz - Department of Metodology, Cádiz, Spain, Bartolomé E. M. ,   Complejo Asistencial Universitario de Palencia - Department of Accident and Department, Palencia, Spain, Larrazábal M. ,   Instituto Kaplan de Psicología Y Sexología - Department of Sexology, Madrid, Spain, Calaveras J. ,   Complejo Asistencial Universitario de Palencia - Department of Accident and Department, Palencia, Spain, Molina N. ,   Complejo Asistencial Universitario de Palencia - Department of Accident and Department, Palencia, Spain
Published: November 2020

Objective: To assess whether patients’ sexual activity has worsened after suffering an Acute Coronary Syndrome (ACS). To know whether to consider sex important and to have an active sexual life has any influence on the demand for sexual counselling after the episode. Design and Method: The sample consisted of men aged <76 with diagnosis of ACS episode, from September 1st 2014 to August 31st 2015, within the area of The University Health Care Hospital Complex of Palencia. They were appointed by a telephone call to hold a personal interview in which they answered an inquiry ad hoc and the validated Beck´s Depression Questionnaire and Sexual Desire and Aversion to Sex (DESEA) Questionnaire. Data were analyzed using the statistical program SPSS Statistics 20.0. Results: Only 30.8% of patients in our sample received sexual counselling after an ACS and 86.5% of those considered it insufficient. After an assessment using non-parametric test for dependent samples and U-Mann-Whitney, we noticed that sexual activity after an ACS has worsened and the fact that those patients consider sex important or have an active sexual life doesn’t significantly influence their request for sexual advice. Conclusions: Very few patients have received sexual counselling after an ACS and most of them require more. In our sample of patients, we may guess that this demand could be due to the fact that a significant number of them no longer have a sexually active life. But, considering sex important or having an active sexual life doesn’t have any influence on that demand.
People Who Buy Sex - Experiences from Our Project
Authors:   Sex Og Samfunn, Oslo, Norway, Royneberg A. , Slettvoll Lien T. ,   Sex Og Samfunn, Oslo, Norway
Published: November 2020

Objective: The project aims to prevent human trafficking and the spread of STIs among people who buy sex. The project is funded by the Norwegian Ministry of Justice and Public Security and the Directorate of Health and Care Services. Design and Method: Our data is based on patient conversations. The service is open for all genders and ages, and for partners of people who buy sex. The patients are offered standard STI testing and given an opportunity to talk to experienced health personnel. Results: Since the implementation in July 2014, we have had about 400 patients. Many of the patients have concerns related to buying sex and see the service as a possibility to talk about their thoughts and behavior. The reasons for buying sex are not one-dimensional, but rather complex and vary from loneliness to seeking pleasure. Diagnosing few incidents of STIs may indicate that people who buy sex in Norway are not at higher risk of contracting STIs, as we may believe. Conclusions: Meeting people who buy sex without prejudice offers a rare opportunity to talk about difficult subjects. We work systematically to obtain knowledge about people who buy sex and hope this knowledge will give us a better foundation in providing the best services possible, how to reduce the number of people being exploited and reduce the spread of STIs.
Reproductive Health and HIV Awareness among Newly Married Egyptian Couples Without Formal Education
Authors:   Faculty of Medicine, Cairo University, Cairo, Egypt, Saleh S. , Saleh W. F. ,   Faculty of Medicine, Cairo University, Cairo, Egypt, Abdelmoty H. I. ,   Faculty of Medicine, Cairo University, Cairo, Egypt, Raslan A. N. ,   Faculty of Medicine, Cairo University, Cairo, Egypt, Fouda U. M. ,   Faculty of Medicine, Cairo University, Cairo, Egypt, Mohesen M. N. ,   Faculty of Medicine, Beni Suef University, Beni Suef, Egypt, Youssef M. A. ,   Faculty of Medicine, Beni Suef University, Beni Suef, Egypt
Published: November 2020

Objective: To assess awareness of several reproductive health and HIV issues and to determine the sources of reproductive health knowledge. Design and Method: A cross-sectional survey of 150 randomly recruited, newly married couples without formal education attending gynecology or andrology outpatient clinics in Cairo, Egypt, was conducted from January 2012 to January 2013. Participants were interviewed separately and asked to respond to a semistructured questionnaire on reproductive health and HIV awareness. Results: Most participants had not received premarital counseling or undergone premarital testing. Awareness about HIV was relatively high: 117 (78.0%) women and 128 (85.3%) men had heard of HIV and had some awareness of the modes of HIV transmission. Only 24 (16.0%) women had ever used a condom compared with 36 (24.0%) men. Only two men out of the 150 couples questioned were aware of the free HIV hotline. Television and friends were the main sources of reproductive health knowledge. Conclusions: Routine premarital counseling and testing by reproductive health, gynecology, and andrology specialists need to be enforced. Mass media is an essential source of knowledge about HIV and reproductive health. Premarital, reproductive health, and HIV education programs need to be improved.
Do Erotic Art and Sexuality Have Something to Share?
Authors:   Isa, Istituto Italiano Sessoanalisi, Salerno, Italy, Strepetova T. , Trotta D. ,   Isa, Istituto Italiano Sessoanalisi, Salerno, Italy, Florio G. ,   Isa, Istituto Italiano Sessoanalisi, Salerno, Italy, Cleffi L. ,   Isa, Istituto Italiano Sessoanalisi, Salerno, Italy, Mangone A. ,   Isa, Istituto Italiano Sessoanalisi, Salerno, Italy
Published: November 2020

Objective: The connection between art and sexuality has always been considered to be solid. Even Freud once said to turn to poets to better understand human sexuality. While in classical Freudian orthodox psychoanalysis is used to understand and explain artworks, we think that the observation of erotic art can be useful in the understanding of human sexuality. Design and Method: Several painters and their erotic production are object of our reflections. Their artistic creations (paintings, drawings, sculptures, collages etc.) are sometimes direct and explicit, other times conceptual and symbolic. Results: The encounter of the artistic work stimulates, in most cases and in the majority of the viewers, an emotional response. People reactions correlate not only to their personal sexual inner world but also to specific erotic themes. Conclusions: The observation and study of erotic art can be useful in our understanding of sexuality and develop our capacity to relate to our sexuality.
The Cultural Meaning of Sexual Pain
Authors:   University of Agder, Grimstad, Norway, Pristed R.
Published: November 2020

This presentation seeks to explore the cultural meaning of sexual pain. The cultural context in this case, being the Scandinavian/Northern European culture; how is it perceived, how is it treated, is it accepted as real, or rejected as “merely psychological”? Is sexual pain compatible with the cultural perception of a “healthy”, “successful” sexuality/body image? Studies show that most women who experience sexual pain, continue the activities that hurt (Laan, ref.). This could be due to psychological or relationship factors, but could also have something to do with the cultural view on pain, and “real” sex as intercourse. This points to intercourse still being the primary sexual activity among heterosexual couples, and also, unfortunately, to sex being something to be endured, not necessarily enjoyed, at least for women. One could wonder what the implications are of treating vulvodynia with lidocaine, enabling intercourse, and merely postponing pain, instead of focusing on non-painful sexual activities, what is the message being sent to both women and their partners?
Consulting with Stakeholders About Dissemination of Sexual Health Research Findings
Authors:   Health Promotion Research Centre, National University of Ireland, Galway, Ireland, Burke L. , Young H. ,   Public Health Improvement Research Network, Cardiff University, Cardiff, United Kingdom, D’Eath M. ,   Health Promotion Research Centre, National University of Ireland, Galway, Ireland, Nic Gabhainn S. ,   Health Promotion Research Centre, National University of Ireland, Galway, Ireland
Published: November 2020

Objective: It is an ethical imperative to disseminate research findings to as wide an audience as possible in a manner that is useable, understandable and appropriate for stakeholders. This study sought to explore and identify appropriate approaches to use with adolescent sexual health survey data among a range of stakeholder groups. Design and Method: A series of qualitative workshops were conducted with groups of young people, parents, youth workers and teachers. Using a semi-structured format, the discussions covered responses to current dissemination formats, information needs, and current and preferred sources and formats of information. Results: All stakeholder groups reported interest in age and gender patterns, but less in social class or other differences within surveys. There was a widespread preference for graphical representations of study findings, rather than text, and a particular emphasis on visual attractiveness among the young people. Opinions varied between groups on preferred formats and use of social media. Young people and youth workers encouraged the involvement of young people themselves in the generation of dissemination materials. Parents and teachers were more concerned with accessibility and particularly that materials would be suitable for photocopying for use with students in classrooms. Conclusions: This consultation provided valuable and constructive insights into suitable approaches to the distribution of research findings to a variety of audiences. Correctly adopted this information has the potential to expand the reaches of survey and other research findings thereby extending knowledge on adolescent sexual health behaviours to a broader audience and across a number of sectors.
Issues of Concern in Sexology
Authors:   University of Agder, Grimstad, Norway, Almås E.
Published: November 2020

Objective: This presentation deal with issues of concern in sexology, as they have appeared in sexological publications in the period between 2001 and 2010. Examples are concerns about evidence base; on one side there is concern that there are so few randomized and controlled studies addressing psychological approaches and sex therapy in itself. On the other hand, there is concern that sexual problems are too complex to fit into standardized manuals, and that such simplifications cannot give justice to the complexity of sexual problems as they are embedded in culture and personal relationships. Another issue of concern is the fragmentation of sexology, due to market driven forces that restrict funding to biomedical ways of treatment, leaving more complex, but also more comprehensive treatment methods without funding. It is for example of concern that the number of AASECT certified sex therapists dropped from 928 in 1987 to 392 in 2002. Design and Method: These issues will be addressed based on a systematic literature search for publications on psychological treatment of sexual problems between 2001 and 2010. Results: A total of 261 publications were found, 49 of these concerned therapy as such. Among these, 38 addressed specific treatment methods, and 11 addressed different topics of discussion. This presentation will analyze the 11 articles and the concerns that are discussed. Conclusions: One of the aims is to pinpoint and highlight important issues for the development of better treatment for sexual problems.
Effect of Oxytocin on the Contractile Response in Rat Vagina
Authors:   Chonnam National University Medical School, Gwagnju, South Korea, Park K. , Kim S. ,   Chonnam National University Medical School, Gwagnju, South Korea, Li Z. ,   Chonnam National University Medical School, Gwagnju, South Korea, Lee H. ,   Chonnam National University Medical School, Gwagnju, South Korea, Yang D. ,   College of Medicine, Hallym University, Seoul, South Korea
Published: November 2020

Objective: Oxytocin (OT) is involved in human reproduction and serves an important role in sexual arousal. Previous studies have documented that OT levels increase during sexual stimulation and arousal with a peak during orgasm in women. The purpose of this study was to investigate the effect of OT on vaginal tissue contractility in normal and castrated rats. Design and Method: Female Sprague-Dawley rats (230–240 g, n=30) were divided into three groups: control (n=10), bilateral ovariectomy (Ovx, n=10), and bilateral ovariectomy followed by subcutaneous injections of 17β-estradiol (Ovx+Est, 50 μg/kg/day, n=10). After 4 weeks, OT receptor level and distribution was assessed in rat vaginal tissue by Western blot analyses and immunohistochemistry. In organ baths, OT-induced changes in isometric tension were also assessed in isolated strips of vaginal tissue. Results: The OT receptor was well localized in subepithelial connective tissue and vaginal smooth muscle. Exogenous application of OT (10-9 - 10-5 M.) showed a dose dependent contractile effect. In the Ovx groups, the contractile effects of OT were significantly decreased compared to control and Ovx+Est groups (p<0.05). Conclusions: These data suggest that OT receptor may have a role in female sexual function. Further studies are needed to evaluate the role of oxytocin in female sexual arousal response.
Clinical and Emotional Aspects of Transgender People
Authors:   Ribeirão Preto Medical School, São Paulo University, Ribeirão Preto, Brazil, Lara L. , Romão A. ,   Ribeirão Preto Medical School, São Paulo University, Ribeirão Preto, Brazil, Santos M. ,   Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil, Giami A. ,   Inserm, Cesp Centre for Research in Epidemiology and Epic Health of Populations, U1018 Team Gender, Sexual and Reproductive, Paris, France, Sá M. ,   Ribeirão Preto Medical School, São Paulo University, Ribeirão Preto, Brazil, Ferriani R. ,   Ribeirão Preto Medical School, São Paulo University, Ribeirão Preto, Brazil, Lerri M. ,   Ribeirão Preto Medical School, São Paulo University, Ribeirão Preto, Brazil
Published: November 2020

Objective: Our aim was to assess clinical characteristics and the rates of attempting suicide in subjects with gender dysphoria (GD). Design and Method: This is a cross-sectional study of adults with GD. Symptoms of anxiety and depression were measured using the Hospital Anxiety and Depression Scale (HADS). A Psychologist performed an individual semi-structured audio-recorded interview to obtain data on sociodemographics (schooling, occupation, professional activity, family income, marital status, place of residence, living partner, type of dwelling, and religion), life habits, marital status, social experience, prevalence of suicide attempts, and history of psychological and psychiatric treatment. Results: Forty-four subjects participated: 36(82%) trans-women and 8(18%) trans-men. GD patients had a high prevalence of anxiety 43(98%), 36(100%) of trans-women and 7(87.5%) of trans-men and depression 36(82%), 29(80.5%) of trans-women and 7(87.5%) of trans-men. A total of 32(73%) subjects attempted suicide. Subjects living with partners, parents, or others had a lower prevalence of depression than those living alone (p=0.03), and subjects who were married had a lower prevalence of depression than those who were dating or single (p=0.03). Conclusions: There was a high prevalence of attempted suicide in this sample. Anxiety and depression were common in patients with GD who were undergoing sex reassignment treatment. The lower prevalence of depression in married patients and in those living with partners, parents, or others suggests that an affective relationship provides emotional support for these subjects. Thus, improving the relationship status may reduce the prevalence of depressive symptoms in GD patients. Paraphilias: D. Sendler, M. Lew-Starowicz: Online forums allow pedophiles to redeem their sins: A qualitative evaluation of pedophilic traits among internet users.
Late-Onset Hypogonadism in Latvia
Authors:   Daugavpils University, Private Practice, Daugavpils, Latvia, Pozarskis A. , Pozarska J. ,   Private Practice, Daugavpils, Latvia, Erenpreiss J. ,   Riga Stradins University, Riga, Latvia
Published: November 2020

Objective: The aim of this study was to examine how common is LOH in Latvian men and to determine the target audience that needs screening for LOH. Design and Method: 300 men over the age of 40 who came to their family doctors and to sexologists were asked to complete the questionnaires for Aging Male Symptoms Rating Scale. Men were divided in three groups based on their age: 40-49 years old, 50-59 years old, and >59 years old. The men who according to the AMS questionnaires had suspicion of LOH symptoms were asked to check their level of testosterone in the blood serum. The authors also have summarized the data on the spread of different chronic diseases among the men. Results: 134 men were asked to check level of testosterone in the blood serum. 29% of men appeared to have hypogonadism. 38% of this men appeared to have adiposity, 77% - hypertension, 18% – diabetes, 51% – dislipidemia, 66%– erectile dysfunction. Among men with normal testosterone level adiposity was found in 29%, hypertension-in 56%, diabetes-in 5%, dislipidemia-in 39%, erectile dysfunction-in 61%. Significantly in hypogonadal men in the group 50-59 years was more frequent hypertension, and in all groups – diabetes mellitus. Conclusions: 1/3 of men aged 40 and older have diagnosis of LOH in the groups under research. It is necessary to check testosterone and free testosterone level: in all men 50-59 years old with arterial hypertension; in all men over the age of 40 with diabetes.
Sexual Addiction: Different Therapeutic Approaches? A Review of the Literature
Authors:   European Fellowship of Sexual Medicine (FECSM), Elmattry Teaching Hospital and Motmaena Medical Center (KSA), Egypt, Attaky A. , Falone Percival M. ,   President of the“ Società Italiana di Psicologia, Psicoterapia e Sessuologia Scientifica”, Italy
Published: November 2020

Objective: Sexual addiction refers to specific condition in which the individual engages in repetitive and increasingly risky sexual behaviors. The behavior serve as a coping mechanism for dealing with painful affects, especially shame due to early trauma and this coping results in loss of control in spite of negative consequences and this term sexual addiction can be used to imply that sexual stimulation acts like a drug on nervous system, and sexual addiction interferes with normal living and causes severe stress on family, friends, loved ones, and one’s work environment. The term sexual addiction appears in the third revised edition of DSM, but it was excluded in the DSM IV, and very recently in DSM-5 as well. The main aim of this article is to provide a general overview of different therapeutic approaches of sexual addiction. Design and Method: We are providing a nonsystematic and worldwide review on treatment of sexual addiction. Results: Appropriate treatment of sexual addiction should include a combination of pharmacological and psychological approaches and psychiatric and somatic co-morbidities that frequently occur with sexual addiction should be integrated into the therapeutic process. Conclusions: Sexual addiction is a challenging topic because of differing societal views about sex and the nature of the addiction, and because of a lack of consensus and empirical research on sexual addiction, clear diagnostic criteria are needed to test the efficacy of psychological and pharmacological treatments in controlled studies. Because of most individuals suffering from this addiction feel shame and embarrassment which makes it difficult for them to seek treatment as with other behavioral addictions (e.g., pathological gambling, compulsive buying) it is hoped that this review will add to the growing awareness and affirm the need for more treatment in this area.
Sexology in Brazil at The Beginning of the 20th Century: The Work of Monsignor Alvaro Negromonte and the Historiography of Sexual Education
Authors:   Nusex - Unesp - São Paulo State University, Araraquara SP, Brazil, Ribeiro P. , Bedin R. ,   Nusex - Unesp - São Paulo State University, Araraquara SP, Brazil, Ribeiro B. ,   Nusex - Unesp - São Paulo State University, Araraquara SP, Brazil
Published: November 2020

Objective: This study has the objective of analyzing the work of Monsignor Alvaro Negromonte, one of the pioneers of Sex Education in Brazil. He wrote a series of books focused on christian formation of youth. Advocate for education in chastity, presented this way of life in his book Sexual Education (1937), his best known and most famous work, which influenced catholic education in Brazil in the early decades of the twentieth century. Design and Method: Using historic bibliografy research, the authors located and examined this important book published by Negromonte that contains information and descriptions about sexual conception and attitudes considered ideals for Negromonte and the catholic church. Results: We verified that the Catholic Church, with conservative ideals, which challenged the secularism in republican educational field, giving way to the discussion of sex education in youth. Consequently, Negromonte points out the need of essentially christian sexual education for young people. This work shows that the consolidation of Sexology in Brazil occurred in the first decades of 20th Century not only from the action of doctors and educators that created extensive work divulged in books and communications in scientific associations, but also by action of catholic church. Conclusions: Despite the conservative aspect of the work of Negromonte, we can not help but note his fundamental driving feature about the issue of sex education for children and adolescents. Like others pioneers, Negromonte made part of a movement that promoted intense, organized, bold and still unknown today actions in sex education in the first decades of XX Century.
Non-point source pollution and long-term effects of best management measures simulated in the Qifeng River Basin in the karst area of Southwest China
Authors: Liying Liang , Litang Qin , Guangsheng Peng , Honghu Zeng , Zheng Liu , Jianwen Yang
Published: November 2020

Non-point source (NPS) pollution has caused serious threats to water quality on a global scale. However, the investigation using a single measure with multi-scenarios for the long-term simulation in karst agricultural watershed is still lacking. In this study, the Annualized Agricultural Non-Point Source Pollution (AnnAGNPS) model was developed to verify the applicability in a karst agricultural watershed. Then, the model was used to determine the best management measures (BMPs) and the reduction rate characteristics under long-term effects (about 10 years) in the watershed. The AnnAGNPS model perform well in simulating in NPS pollution with R2 (0.95 for runoff, 0.93 for TN, and 0.93 for TP, respectively) and NSE (0.95 for runoff, 0.53 for TN, and 0.57 for TP, respectively). The output of total nitrogen (TN) and total phosphorus (TP) primarily occurred in the rainy season (up to 80%). The loss of mass of TN and TP were mainly observed in orchards and woodlands in the upstream of each sub-basin. The results from AnnAGNPS model demonstrated that different BMPs had significant impacts on the reduction of NPS pollution. Furthermore, a same BMPs measure showed it was closely related to land use in the watershed. In the Qifeng River watershed, stubble tillage (ST) showed to be useful with relatively good reduction rates (16.64% for sediment, 17.85% for TN, and 17.80% for TP, respectively). The simulation results indicated that AnnAGNPS was a valuable tool after validation for the planning and management of the watershed in karst areas.
Receptor Dynamics in Molecular Recognition by Cryo-EM and Molecular Simulation
Authors: Zhao Yizhen , Wang He , Zang Yongjian , Zhu Xun , Zhang Shengli , Zhang Lei
Published: November 2020

The appropriate selection of initial receptor structure has been the "cornerstone" or
foundation of successful structure-based virtual screening (SBVS), and plagued the structure-based
design with a significant practical problem to determine the major physiological states or important
transition states of receptors (e.g. proteins with multiple low-energy conformations and liganddependent
conformational dynamics). It is well known that current SBVS methods lack the
capacity to capture and characterize the intrinsic receptor flexibility with ideal cost-effectiveness.
In recent years, cryoelectron microscopy (cryo-EM) has been routinely applied in the
determination of biomolecular assemblies within the physiological state. In this work, we review
the roles of cryo-EM and ensemble docking methods to present the intrinsically dynamic behavior
of biomacromolecules, as well as the ever-improving estimation of ligand binding affinities and
receptor-ligand thermodynamics. Finally, we also provide a viewpoint for further research works
on modeling receptor dynamics.
A Refined Framework for Precision and Translational Proteomics in Clinical Research
Authors: Wang Min , Chen Daozhen , Xia Yankai , Zhou Tao , Jiang Shi-Wen
Published: November 2020

Most clinical related proteomic studies were aimed to screen potential biomarkers for
clinical usage. However, it is known that only a few candidates can be validated in later stages. Besides
clinical biomarkers, it is also necessary to identify key proteins to better understand the molecular
mechanism of human diseases. Here, we updated the connotations of precision and translational
proteomics and proposed a refined research framework for clinical proteomics. We abstracted
the framework as a three-tier system: to determine research objectives and approaches for achieving
a certain purpose, to choose the appropriate methods for optimal results, and to apply a standardized
experimental procedure for reliable and reproducible results. Started from the initial discovery
stage, we divided the following proteomics-driven translational studies into two directions:
biomarker screening and mechanism investigation. We also discussed possible causes that may
lead to high rates of experimental variation and low rates of follow-up validation. Moreover, we
pointed out that the main bottlenecks for the identification of effective targets are data interpretation
and statistical inference. Finally, we emphasized that the transparency of experimental design
and results can help to ensure data quality. Conclusively, the refined framework provides constructive
recommendations and comprehensive guides for designing and performing clinical related proteomic
studies with the aim of obtaining reliable and reproducible results. It can also help to further
promote the standardization and integration of proteomic studies.
Synthesis, Cytotoxicity, Antioxidant and Antimicrobial Activity of Indole Based Novel Small Molecules
Authors: Kurt-Kızıldoğan Aslıhan , Otur Çiğdem , Yılmaz Can , Arslan Sevki , Mutlu Dogukan , Kivrak Arif , Algso Muheb , Kayhan Abdussamet , Çetin Doğan , Konus Metin
Published: November 2020

Aim:

In this study experiments were carried out to explore antioxidant, antimicrobial,
cytotoxic properties of novel indole derivative 1-ethyl-2-phenyl-3-phenylethyl-3-thiophen-2-yl-1Hindole
(EPI) together with its effect on glutathione S-transferases (GST) activities in human liver
carcinoma (HepG2) cells.

Background::

Indoles probably represent one of the most important heterocyclic structures that have
been attracting the interest of many scientists in drug discovery.

Objective:

The present study was carried out to explore antioxidant, antimicrobial, cytotoxic properties
of novel indole derivative 1-ethyl-2-phenyl-3-phenylethyl-3-thiophen-2-yl-1H-indole (EPI) and its
effect on glutathione S-transferases (GST) activities in human liver carcinoma (HepG2) cells.

Materials and Methods:

Pd-catalyst Sonogashira coupling reactions, MTT Assay, Antioxidant
capacity test, Antimicrobial test, GST enzyme activity test.

Results:

1-ethyl-2-phenyl-3-(phenylethynyl)-1H-indole had antioxidant and antimicrobial properties.
It displayed significant induction in glutathione S-transferases (GST) enzyme activity in human liver
cancer cell lines (HepG2), but cytotoxic effect on all tested cancer cell lines could not be observed.

Conclusion::

All of these results showed that 1-ethyl-2-phenyl-3-(phenylethynyl)-1H-indole had
antioxidant and antimicrobial properties without cytotoxic effect, which could make it a promising
active component with further studies.
Identification of Cancerlectins By Using Cascade Linear Discriminant Analysis and Optimal g-gap Tripeptide Composition
Authors: Yang Liangwei , Gao Hui , Wu Keyu , Zhang Haotian , Li Changyu , Tang Lixia
Published: November 2020

Background:

Lectins are a diverse group of glycoproteins or glycoconjugate proteins
that can be extracted from plants, invertebrates and higher animals. Cancerlectins, a kind of lectins,
which play a key role in the process of tumor cells interacting with each other and are being employed
as therapeutic agents. A full understanding of cancerlectins is significant because it provides
a tool for the future direction of cancer therapy.

Objective:

To develop an accurate and practically useful timesaving tool to identify cancerlectins.
A novel sequence-based method is proposed along with a correlative webserver to access the proposed
tool.

Methods:

Firstly, protein features were extracted in a newly feature building way termed, g-gap
tripeptide composition. After which a proposed cascade linear discriminant analysis (Cascade
LDA) is used to alleviate the high dimensional difficulties with the Analysis Of Variance (ANOVA)
as a feature importance criterion. Finally, Support Vector Machine (SVM) is used as the classifier
to identify cancerlectins.

Results:

The proposed method achieved an accuracy of 91.34% with sensitivity of 89.89%, specificity
of 92.48% and an 0.8318 Mathew’s correlation coefficient based on only 13 fusion features
in jackknife cross validation, the result of which is superior to other published methods in this domain.

Conclusion:

In this study, a new method based only on primary structure of protein is proposed
and experimental results show that it could be a promising tool to identify cancerlectins. An openaccess
webserver is made available in this work to facilitate other related works.
Recent Patents and Advances on Nanotechnologies against Coronavirus
Authors: Abedini-Nassab Roozbeh , Mahdaviyan Naeemeh
Published: November 2020

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is one of the seven
known coronaviruses infecting humans; HKU1, 229E, NL63, OC43, Acute Respiratory Syndrome
Coronavirus (SARS-CoV), Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and
SARS-CoV-2, the last three of which can cause severe symptoms in patients. COVID-19, previously
known as 2019 novel coronavirus, caused by SARS-CoV-2, was first reported in Wuhan,
China, in late 2019, and quickly resulted in a major epidemic across the world. Although the origin
of SARS-CoV-2 is not clear yet, genome sequencing results suggest that this is the third reported
spillover of an animal coronavirus to humans, from 2002. The development of detection, therapeutic,
and prevention strategies for COVID-19 is a fundamental task towards curing infected people
and competing with the pandemic. Because of their similarities, scientists believe that treatment/
detection methods similar to what were used against the illnesses caused by SARS-CoV or
MERS-CoV may be effective for curing/detecting COVID-19. Here, we review the recent nanotechnology
techniques used for treating and testing SARS-CoV, MERS-CoV, and SARS-CoV-2,
and potential therapeutic options for curing COVID-19. This patent summarizes the recent findings
of advances on Nanotechnologies against Coronavirus.
Pengembangan nilai Islami peserta didik melalui integrasi Alquran dan Hadis dalam pembelajaran biologi
Authors: Mualimin Mualimin
Published: November 2020

National education aims to shape people of faith and piety and noble character, not only to develop the potential of cognitive intelligence. One effort that can be done to realize these goals is to develop Islamic values of students through the integration of the Qur'an and Hadith in learning biology. Through the integration of the Qur'an and Hadith in biology learning, students can gain knowledge about the concept of biology while at the same time developing Islamic values. Integration of the Qur'an and Hadith in learning biology can be done by: 1) Recording and analyzing verses of the Qur'an and Hadith that are in accordance with the subject or biological material both implicitly or explicitly, 2) Implementing the integration of verses of the Qur'an and Hadith found in the process of learning biology by selecting certain appropriate learning models; 3) Evaluating the integration process that has been done in the biology learning process. The integration of Al-Qur'an and Hadith in learning biology needs to be done to foster Islamic values in students to achieve national education goals.