bluuebunny/crossref_metadata_2025 huggingface dataset:
Implications of Lifestyle Factors and Polygenic Risk Score for Absolute Risk Prediction of Colorectal Neoplasm and Risk-Adapted Screening
Authors: Chen Hongda , Liu Li , Lu Ming , Zhang Yuhan , Lu Bin , Zhu Ying , Tian Jianbo , Li Xinying , Nie Shaofa , Miao Xiaoping , Dai Min
Published: July 2021

Background: Estimation of absolute risk of developing colorectal neoplasm is essential for personalized colorectal cancer (CRC) screening. We developed models to determine relative and absolute risks of colorectal neoplasm based on lifestyle and genetic variants and to validate their application in risk-adapted screening.

Methods: We prospectively collected data from 203 advanced neoplasms, 464 non-advanced adenomas, and 1,213 healthy controls from a CRC screening trial in China in 2018–2019. The risk prediction model based on four lifestyle factors and a polygenic risk score (PRS) consisted of 19 CRC-associated single-nucleotide polymorphisms. We assessed the relative and 10-year absolute risks of developing colorectal neoplasm and the yield of a risk-adapted screening approach incorporating risk models, fecal immunochemical test, and colonoscopy.

Results: Compared to the participants with favorable lifestyle and lower PRS, those with unfavorable lifestyle and higher PRS had 2.87- and 3.79-fold higher risk of colorectal neoplasm in males and females, respectively. For a 50-year-old man or a 50-year-old woman with the highest risk profile, the estimated 10-year absolute risk of developing colorectal neoplasm was 6.59% (95% CI: 6.53–6.65%) and 4.19% (95% CI: 4.11–4.28%), respectively, compared to 2.80% (95% CI: 2.78–2.81%) for men and 2.24% (95% CI: 2.21–2.27%) for women with the lowest risk profile. The positive predictive value for advanced neoplasm was 31.7%, and the number of colonoscopies needed to detect one advanced neoplasm was 3.2.

Conclusion: The risk models, absolute risk estimates, and risk-adapted screening presented in our study would contribute to developing effective personalized CRC prevention and screening strategies.
Early Blindness Limits the Head-Trunk Coordination Development for Horizontal Reorientation
Authors: Esposito Davide , Bollini Alice , Gori Monica
Published: July 2021

During locomotion, goal-directed orientation movements in the horizontal plane require a high degree of head-trunk coordination. This coordination is acquired during childhood. Since early visual loss is linked to motor control deficits, we hypothesize that it may also affect the development of head-trunk coordination for horizontal rotations. However, no direct evidence exists about such a deficit. To assess this hypothesis, we tested early blind and sighted individuals on dynamic sound alignment through a head-pointing task with sounds delivered in acoustic virtual reality. Participants could perform the head-pointing with no constraints, or they were asked to immobilize their trunk voluntarily. Kinematics of head and trunk were assessed individually and with respect to each other, together with spatial task performance. Results indicated a head-trunk coordination deficit in the early blind group; yet, they could dampen their trunk movements so as not to let their coordination deficit affect spatial performance. This result highlights the role of vision in the development of head-trunk coordination for goal-directed horizontal rotations. It also calls for clarification on the impact of the blindness-related head-trunk coordination deficit on the performance of more complex tasks akin to daily life activities such as steering during locomotion or reaching to targets placed sideways.
Decreased Functional Connectivity of Vermis-Ventral Prefrontal Cortex in Bipolar Disorder
Authors: Li Huanhuan , Liu Hu , Tang Yanqing , Yan Rongkai , Jiang Xiaowei , Fan Guoguang , Sun Wenge
Published: July 2021

Objectives: To investigate changes in functional connectivity between the vermis and cerebral regions in the resting state among subjects with bipolar disorder (BD).

Methods: Thirty participants with BD and 28 healthy controls (HC) underwent the resting state functional magnetic resonance imaging (fMRI). Resting-state functional connectivity (rsFC) of the anterior and posterior vermis was examined. For each participant, rsFC maps of the anterior and posterior vermis were computed and compared across the two groups.

Results: rsFC between the whole vermis and ventral prefrontal cortex (VPFC) was significantly lower in the BD groups compared to the HC group, and rsFC between the anterior vermis and the middle cingulate cortex was likewise significantly decreased in the BD group.

Limitations: 83.3% of the BD participants were taking medication at the time of the study. Our findings may in part be attributed to treatment differences because we did not examine the effects of medication on rsFC. Further, the mixed BD subtypes in our current study may have confounding effects influencing the results.

Conclusions: These rsFC differences of vermis-VPFC between groups may contribute to the BD mood regulation.
Hardware Implementation of Differential Oscillatory Neural Networks Using VO 2-Based Oscillators and Memristor-Bridge Circuits
Authors: Shamsi Jafar , Avedillo María José , Linares-Barranco Bernabé , Serrano-Gotarredona Teresa
Published: July 2021

Oscillatory Neural Networks (ONNs) are currently arousing interest in the research community for their potential to implement very fast, ultra-low-power computing tasks by exploiting specific emerging technologies. From the architectural point of view, ONNs are based on the synchronization of oscillatory neurons in cognitive processing, as occurs in the human brain. As emerging technologies, VO2 and memristive devices show promising potential for the efficient implementation of ONNs. Abundant literature is now becoming available pertaining to the study and building of ONNs based on VO2 devices and resistive coupling, such as memristors. One drawback of direct resistive coupling is that physical resistances cannot be negative, but from the architectural and computational perspective this would be a powerful advantage when interconnecting weights in ONNs. Here we solve the problem by proposing a hardware implementation technique based on differential oscillatory neurons for ONNs (DONNs) with VO2-based oscillators and memristor-bridge circuits. Each differential oscillatory neuron is made of a pair of VO2 oscillators operating in anti-phase. This way, the neurons provide a pair of differential output signals in opposite phase. The memristor-bridge circuit is used as an adjustable coupling function that is compatible with differential structures and capable of providing both positive and negative weights. By combining differential oscillatory neurons and memristor-bridge circuits, we propose the hardware implementation of a fully connected differential ONN (DONN) and use it as an associative memory. The standard Hebbian rule is used for training, and the weights are then mapped to the memristor-bridge circuit through a proposed mapping rule. The paper also introduces some functional and hardware specifications to evaluate the design. Evaluation is performed by circuit-level electrical simulations and shows that the retrieval accuracy of the proposed design is comparable to that of classic Hopfield Neural Networks.
Investigating Post-translational Modifications in Neuropsychiatric Disease: The Next Frontier in Human Post-mortem Brain Research
Authors: Grubisha Melanie J. , Sweet Robert A. , MacDonald Matthew L.
Published: July 2021

Gene expression and translation have been extensively studied in human post-mortem brain tissue from subjects with psychiatric disease. Post-translational modifications (PTMs) have received less attention despite their implication by unbiased genetic studies and importance in regulating neuronal and circuit function. Here we review the rationale for studying PTMs in psychiatric disease, recent findings in human post-mortem tissue, the required controls for these types of studies, and highlight the emerging mass spectrometry approaches transforming this research direction.
Metastatic Urachal Carcinoma Treated With Several Different Combined Regimens: A Case Report
Authors: Zheng Han , Song Wei , Feng Xiemin , Zhao Hong
Published: July 2021

Urachal carcinoma is a rare bladder malignance. This study presents a case of an elderly patient with urachal carcinoma who was found to have pulmonary metastases 1 year after 5 recurrent resections. The patient was treated with up to 7 different chemotherapy regimens, including a VEGF monoclonal antibody and anti-PD-1 antibody. This is the first report of PD-1 antibody being used in patients with urachus, although the disease progressed after only four cycles of the application. The patient’s disease was controlled by the FOLFIRI combined with the VEGF monoclonal antibody regimen. The most prominent issues at present are the difficulty of obtaining drugs for rare cancers and the lack of late-stage clinical trials to guide therapeutic decisions.
Management of Clinically Involved Lateral Lymph Node Metastasis in Locally Advanced Rectal Cancer: A Radiation Dose Escalation Study
Authors: Pang Xiaolin , Huang Liang , Ma Yan , Liu Zhanzhen , Xie Peiyi , Liu Hailing , Wan Xiangbo , Liu Shuai , Zheng Jian
Published: July 2021

Background

Patients with lateral lymph nodes (LLNs) metastasis are not effectively treated with neoadjuvant chemoradiotherapy. This study aimed to compare the efficacy of three neoadjuvant therapeutic regimens, namely, chemotherapy, chemoradiotherapy, and chemoradiotherapy with a dose boost of LLNs, and to identify the optimal approach for treating LLNs metastasis of locally advanced rectal cancer.

Methods

A total of 202 patients with baseline LLNs metastasis (short axis ≥5 mm) and treated with neoadjuvant treatment, followed by radical surgery from 2011 to 2019, were enrolled. The short axis of the LLNs on baseline and restaging MRI were recorded. Survival outcomes were compared.

Results

In the booster subgroup, shrinkage of LLNs was significantly greater than in the neoadjuvant chemotherapy and chemoradiotherapy subgroups (P <0.001), without increasing radiation related side effects (P = 0.121). For patients with baseline LLNs of short axis ≥5 mm in the booster subgroup, the response rate (short axis <5 mm on restaging MRI) was 72.9%, significantly higher than patients in the neoadjuvant chemotherapy subgroup (48.9%, P = 0.007) and higher than for patients in the neoadjuvant chemoradiotherapy group (65.0%), but there was no statistical difference (P = 0.411). The 3-year local recurrence and lateral local recurrence rates were both 2.3% in the dose booster group, which were lower than those of the other two subgroups (local recurrence: P <0.001; lateral local recurrence: P <0.001). The short axis of lateral lymph nodes (≥5 and <5 mm) on restaging MRI was an independent risk factor for prognosis (P <0.05).

Conclusion

Radiation dose boost is an effective way of increasing the response rate and decreasing recurrence rates. The restaging LLNs with short axis ≥5 mm is a predictor of poor prognosis.
Adherence to Computer-Assisted Surgical Planning in 136 Maxillofacial Reconstructions
Authors: Ma Hongyang , Shujaat Sohaib , Van Dessel Jeroen , Sun Yi , Bila Michel , Vranckx Jan , Politis Constantinus , Jacobs Reinhilde
Published: July 2021

Objective

To investigate the adherence to initially planned maxillofacial reconstructions using computer-assisted surgery (CAS) and to identify the influential factors affecting its compliance for maxillofacial reconstruction.

Patients and Methods

A retrospective analysis of 136 computer-assisted maxillofacial reconstructive surgeries was conducted from January 2014 to June 2020. The categorical parameters involved age, gender, disease etiology, disease site, defect size, bone flap segments, and flap type. Apart from descriptive data reporting, categorical data were related by applying the Fisher-exact test, and a p-value below 5% was considered statistically significant (P < 0.05).

Results

The main reasons for partial or non-adherence included unfitness, patient health condition, and other subjective reasons. Out of the total patient population, 118 patients who underwent mandibular reconstruction showed higher CAS compliance (83.9%) compared to the 18 midface reconstruction (72.2%) without any statistically significant difference (p = 0.361). Based on the size of the defect, a significantly higher CAS compliance (p = 0.031) was observed with a minor defect (80.6%) compared to the large-sized ones (74.1%). The bone flaps with two or more segments were significantly (p = 0.003) prone to observe a partial (15.4%) or complete (12.8%) discard of the planned CAS compared to the bone flaps with less than two segments. The malignant tumors showed the lowest CAS compliance when compared to other disorders without any significant difference (p = 0.1).

Conclusion

The maxillofacial reconstructive surgical procedures offered optimal compliance to the initially planned CAS. However, large-sized defects and multiple bone flap segments demonstrated a higher risk of partial or complete abandonment of the CAS.
Ikaros-Associated Diseases: From Mice to Humans and Back Again
Authors: Boast Brigette , Nunes-Santos Cristiane de Jesus , Kuehn Hye Sun , Rosenzweig Sergio D.
Published: July 2021

The normal expression of Ikaros (IKZF1) is important for the proper functioning of both the human and murine immune systems. Whilst our understanding of IKZF1 in the immune system has been greatly enhanced by the study of mice carrying mutations inIkzf1, analyses of human patients carrying germlineIKZF1mutations have been instrumental in understanding its biological role within the human immune system and its effect on human disease. A myriad of different mutations inIKZF1have been identified, spanning across the entire gene causing differential clinical outcomes in patients including immunodeficiency, immune dysregulation, and cancer. The majority of mutations in humans leading to IKAROS-associated diseases are single amino acid heterozygous substitutions that affect the overall function of the protein. The majority of mutations studied in mice however, affect the expression of the protein rather than its function. Murine studies would suggest that the complete absence of IKZF1 expression leads to severe and sometimes catastrophic outcomes, yet these extreme phenotypes are not commonly observed in patients carryingIKZF1heterozygous mutations. It is unknown whether this discrepancy is simply due to differences in zygosity, the role and regulation of IKZF1 in the murine and human immune systems, or simply due to a lack of similar controls across both groups. This review will focus its analysis on the current literature surrounding what is known about germline IKZF1 defects in both the human and the murine immune systems, and whether existing mice models are indeed accurate tools to study the effects of IKZF1-associated diseases.
Mutational Characteristics of Causative Genes in Chinese Hereditary Spherocytosis Patients: a Report on Fourteen Cases and a Review of the Literature
Authors: Wang Dong , Song Li , Shen Li , Zhang Kaihui , Lv Yuqiang , Gao Min , Ma Jian , Wan Ya , Gai Zhongtao , Liu Yi
Published: July 2021

Background: Hereditary spherocytosis (HS), characterized by the presence of spherocytic red cells in peripheral blood, hemolysis, splenomegaly, jaundice, and gallstones, is a common form of inherited hemolytic anemia (HA). To date, five causative genes associated with HS have been identified, including ANK1, SPTB, SPTA1, SLC4A1, and EPB42.

Methods: Clinically suspected patients with HS or undiagnosed HA from 14 Chinese families were enrolled in this study. We presented the patients’ clinical features and identified the causative gene variants in these patients using whole exome sequencing (WES), with 10 novel and four reported mutations in the ANK1 and SPTB genes (seven mutations in ANK1 and seven in SPTB), individually. Then, we reviewed all available literature on Chinese HS patients from 2000 to 2020 in PubMed and Chinese Journals with genetic results and clinical information, to delineate gene mutation spectrum and potential correlation with phenotypes.

Results: A total of 158 variants (including 144 in previous reports and 14 in this study) indicated that ANK1 (46%) and SPTB (42%) were the most frequently mutated genes in Chinese HS patients, followed by SLC4A1 (11%) and SPTA1 (1%), while no mutations in EPB42 was reported. Most of the mutations in ANK1 and SPTB were nonsense (26/73 in ANK1 and 32/66 in SPTB) and frameshift (20/73 in ANK1 and 15/66 in SPTB), while missense mutations (14/18) accounted for the majority in SLC4A1. The higher mutation frequency of ANK1 was found in its exon 8, 9, 26, and 28. The majority of mutations in SPTB were located in its exon 13, 15, and 18–30, whereas mutations in SLC4A1 were scattered throughout the entire region of the gene.

Conclusion: Our study expanded the mutation spectrum of ANK1 and SPTB. Furthermore, we clarified the mutational characteristics of causative genes by reviewing all available literature on Chinese patients with HS.
Calcium Biofortification of Crops–Challenges and Projected Benefits
Authors: Knez Marija , Stangoulis James C. R.
Published: July 2021

Despite Calcium (Ca) being an essential nutrient for humans, deficiency of Ca is becoming an ensuing public health problem worldwide. Breeding staple crops with higher Ca concentrations is a sustainable long-term strategy for alleviating Ca deficiency, and particular criteria for a successful breeding initiative need to be in place. This paper discusses current challenges and projected benefits of Ca-biofortified crops. The most important features of Ca nutrition in plants are presented along with explicit recommendations for additional exploration of this important issue. In order for Ca-biofortified crops to be successfully developed, tested, and effectively implemented in most vulnerable populations, further research is required.
Which Head and Neck Cancer Patients Are Most at Risk of High Levels of Fear of Cancer Recurrence
Authors: Rogers Simon N. , Monssen Camilla , Humphris Gerald M. , Lowe Derek , Kanatas Anastasios
Published: July 2021

Background: Fear of cancer recurrence (FCR) is recognized as a common concern for patients with head and neck cancer (HNC). The aim of this study is to describe in greater detail the demographic and clinical characteristics of HCN patients who indicate a high level of FCR in their review consultation.

Methods: A pragmatic cluster-controlled trial was conducted between January 2017 and December 2018 at two UK HNC centers (Leeds and Liverpool) to test the efficacy of a prompt tool called the Patient Concerns Inventory (PCI). Patients completed the PCI and the UW-QOLv4 which included a single 5 category rating of FCR. Secondary statistical analyses focused on variables associated with high FCR.

Results: Two hundred and eighty-eight trial patients were recruited in this trial. At a median of 194 days after diagnosis and 103 days after the end of treatment 8% stated (n = 24) “I get a lot of fears of recurrence and these can really preoccupy my thoughts” and 3% (n = 8) “I am fearful all the time that my cancer might return, and I struggle with this.” Thus, 11% (n = 32) responded in the worst two categories, 95% Confidence interval 7.7–15.3% for high FCR. Stepwise logistic regression resulted in female gender (p < 0.001), age (p = 0.007), and receiving financial benefits (p = 0.01) as independent predictors.

Conclusions: Around one in ten HNC patients attending routine outpatient follow-up consultations report high FCR, however for female patients under the age of 55 the rate was one in three. This group requires specialist attention and could be the focus of a multicenter intervention trial.
Attachment Style and Jealousy in the Digital Age: Do Attitudes About Online Communication Matter?
Authors: Sullivan Kieran T.
Published: July 2021

Romantic jealousy, a complex response to a real or perceived threat to a romantic relationship, can have serious negative consequences for individuals, partners and perceived rivals. The likelihood of a jealous response is heightened among individuals who experience attachment anxiety, and online communication and social media provide unique fodder for romantic jealousy. The purpose of the current study is to test whether the association between attachment anxiety and online jealousy (jealous response to ambiguous hypothetical online scenarios) is moderated by negative attitudes about online communication. Individuals in dating relationships were asked about attachment anxiety and attitudes about online communication (i.e., apprehension and concern about misunderstandings) as well as emotional, cognitive, and behavioral online jealousy. Hierarchical linear regression revealed an attachment anxiety-attitude interaction, such that the link between attachment anxiety and jealousy was stronger for participants with relatively low levels of negative attitudes about online communication compared to participants with relatively high levels of negative attitudes. The current study expands knowledge about attachment anxiety and jealousy in the context of online communication and social media, and highlights the importance of considering attitudes about online communication when studying relationship processes in the digital arena.
Rapid Eye Movement Sleep Deprivation Combined With Fluoxetine Protects Against Depression-Induced Damage and Apoptosis in Rat Hippocampi via A1 Adenosine Receptor
Authors: Ju Xuan , Wang Shengdong , Yan Pan , Zhu Chunyan , Hu Xiwen , Dong Jiezheng , Tan Zhonglin
Published: July 2021

Background: Rapid eye movement sleep deprivation (REMSD) and fluoxetine affect depression, yet the detailed molecular mechanisms were not clear.

Methods: Rat depression chronic unpredictable stress was constructed, and the body weight of rats was measured. The efficacy of REMSD and fluoxetine on the pleasure experience, exploration, and cognition of rats with depression was determined by the Sucrose preference test, the open field test, and Morris water task, respectively. The effects of REMSD and fluoxetine on depression-induced damage and apoptosis in rat hippocampi were detected using hematoxylin–eosin staining and terminal transferase-mediated biotin 2′-deoxyuridine, 5′-triphosphate nick end labeling. A1 adenosine receptor content was measured by immunohistochemistry. Relative expressions of the A1 adenosine receptor, proteins related to apoptosis (B Bcl-2-associated X protein; B-cell lymphoma 2), phosphoinositide 3-kinase, P38 mitogen-activated protein kinase, cFos, and adenosine deaminase RNA specific two were quantified by quantitative real-time polymerase chain reaction and Western blot as needed.

Results: Depression decreased rat weight. REMSD combined with fluoxetine increased body weight, prompted rat behavior, alleviated depression-induced damage, attenuated apoptosis, and promoted A1 adenosine receptor level in rat hippocampi. Furthermore, the combined therapy upregulated expressions of A1 adenosine receptor, B-cell lymphoma 2, and phosphoinositide 3-kinase but downregulated those of B-cell lymphoma 2-associated X protein, P38 mitogen-activated protein kinase, cFos, and adenosine deaminase RNA specific 2 in the hippocampi of rats with depression.

Conclusion:REMSD combined with fluoxetine protected rats against depression-induced damage and apoptosis in the hippocampus via the A1 adenosine receptor, providing a possible treatment strategy for depression.
Differences Between the Psychiatric Symptoms of Healthcare Workers Quarantined at Home and in the Hospital After Contact With a Patient With Middle East Respiratory Syndrome
Authors: Seong Su Jeong , Kim Hyung Joon , Yim Kyung Mi , Park Ji Won , Son Kyung Hoon , Jeon Yeong Ju , Hwang Jae Yeon
Published: July 2021

Objective: Although quarantine is an effective measure for the prevention of the spread of infectious diseases, it may have negative effects on the mental health of the isolated individual. During the 2015 outbreak of the Middle East Respiratory Syndrome (MERS) in Korea, healthcare workers came in contact with patients with MERS were quarantined either at home or in a hospital ward. In this study, we aimed to compare the psychiatric symptoms of these employees according to the method of quarantine.

Methods: All 146 quarantined staff completed self-report questionnaires. Depressive symptoms were measured using the Patient Health Questionnaire-9, anxiety symptoms were assessed using Spielberger's State-Trait Anxiety Inventory, and acute stress disorder (ASD) symptoms were evaluated using the Stanford Acute Stress Reaction Questionnaire.

Results: The in-hospital quarantine group had a higher rate of symptoms of depression (p < 0.001) and ASD (p = 0.014) than the group quarantined at home. Logistic regression analysis showed that respondents quarantined in the hospital (OR = 6.342; 95% CI 1.853–21.708) and those quarantined for longer periods (OR = 1.153, 95% CI = 1.036–1.285) had a higher risk of depressive symptoms.

Conclusions: In-hospital quarantine and quarantine for longer periods increase the risk of depressive symptoms. When quarantine measures are taken, certain measures are needed to minimize the risk of psychiatric problems. Appropriate interventions should be implemented if psychiatric problems occur.
Does the Internet Use Improve the Mental Health of Chinese Older Adults?
Authors: Xie Lin , Yang Hua-lei , Lin Xue-yu , Ti Shi-ming , Wu Yuan-yang , Zhang Shuo , Zhang Si-qing , Zhou Wan-li
Published: July 2021

Purpose: The Internet has become an important part of daily life. However, older adults in China remain digital refugees amid the rapid development of digital information technology. This study attempts to scientifically answer how Internet use affects the subjective welfare of older adults.

Method: Using data from the 2014 and 2016 China Longitudinal Aging Social Survey (CLASS), a combination of ordinary least squares, ordered logit regression models, and propensity score matching (PSM) models were used to analyze the effects of Internet use on the mental health of Chinese older adults.

Results: Our findings suggest that Internet use affects the mental health of older adults and increases the incidence of their depressive symptoms. These findings are robust to changing the key indicators, research method, and sample. Further heterogeneity analysis reveals that the negative effects on mental health are more evident for specific groups of older adults, such as those who are women, younger and middle-aged, high-income, non-rural Hukou, less educated, and living with others.

Conclusions: Cultivating the ability of older adults to use the Internet and maintain a rational attitude while doing so can prevent its negative impact on their life satisfaction. Moreover, it can improve their attitudes toward using the technology and reduce their anxiety.
Lung Cancer Segmentation With Transfer Learning: Usefulness of a Pretrained Model Constructed From an Artificial Dataset Generated Using a Generative Adversarial Network
Authors: Nishio Mizuho , Fujimoto Koji , Matsuo Hidetoshi , Muramatsu Chisako , Sakamoto Ryo , Fujita Hiroshi
Published: July 2021

Purpose: The purpose of this study was to develop and evaluate lung cancer segmentation with a pretrained model and transfer learning. The pretrained model was constructed from an artificial dataset generated using a generative adversarial network (GAN).

Materials and Methods: Three public datasets containing images of lung nodules/lung cancers were used: LUNA16 dataset, Decathlon lung dataset, and NSCLC radiogenomics. The LUNA16 dataset was used to generate an artificial dataset for lung cancer segmentation with the help of the GAN and 3D graph cut. Pretrained models were then constructed from the artificial dataset. Subsequently, the main segmentation model was constructed from the pretrained models and the Decathlon lung dataset. Finally, the NSCLC radiogenomics dataset was used to evaluate the main segmentation model. The Dice similarity coefficient (DSC) was used as a metric to evaluate the segmentation performance.

Results: The mean DSC for the NSCLC radiogenomics dataset improved overall when using the pretrained models. At maximum, the mean DSC was 0.09 higher with the pretrained model than that without it.

Conclusion: The proposed method comprising an artificial dataset and a pretrained model can improve lung cancer segmentation as confirmed in terms of the DSC metric. Moreover, the construction of the artificial dataset for the segmentation using the GAN and 3D graph cut was found to be feasible.
Short-Range Wireless Transmission in the 300 GHz Band Using Low-Profile Wavelength-Scaled Dielectric Cuboid Antennas
Authors: Yamada Kazuki , Samura Yuto , Minin Oleg V. , Kanno Atsushi , Sekine Norihiko , Nakajima Junichi , Minin Igor V. , Hisatake Shintaro
Published: July 2021

A short-range terahertz (THz) wireless transmission in the 300 GHz band is demonstrated using low-profile wavelength-scaled dielectric transmitting and receiving cuboid antennas (DCAs). These dielectric cuboid antennas are made of polytetrafluoroethylene with dimensions of approximately 1.2 mm × 1.2 mm × 1.3 mm. The near-field pattern of a DCA at 300 GHz was measured using an electro-optic sensing technique, and its far-field pattern characterization was based on the near-field to far-field transformation. The measured antenna gain was 15.06 ± 0.06 dBi. By employing DCAs as transmitting and receiving antennas, a 17.5 Gbps data transmission rate at distances of approximately 200 and 50 mm with bit error rates of 3.31 × 10–3 and 7.51 × 10–7 respectively, is demonstrated. The proposed mesoscopic scale DCA is a promising antenna type in intra-device communications and Kiosk download applications for future mobile devices operating in the 300 GHz band.
Cloud-Enabled High-Altitude Platform Systems: Challenges and Opportunities
Authors: Mershad Khaleel , Dahrouj Hayssam , Sarieddeen Hadi , Shihada Basem , Al-Naffouri Tareq , Alouini Mohamed-Slim
Published: July 2021

Augmenting ground-level communications with flying networks, such as the high-altitude platform system (HAPS), is among the major innovative initiatives of the next generation of wireless systems (6G). Given HAPS quasi-static positioning at the stratosphere, HAPS-to-ground and HAPS-to-air connectivity frameworks are expected to be prolific in terms of data acquisition and computing, especially given the mild weather and quasi-constant wind speed characteristics of the stratospheric layer. This paper explores the opportunities stemming from the realization of cloud-enabled HAPS in the context of telecommunications applications and services. The paper first advocates for the potential physical advantages of deploying HAPS as flying data-centers, also known as super-macro base stations. The paper then describes various cloud services that can be offered from the HAPS and the merits that can be achieved by this integration, such as enhancing the quality, speed, and range of the offered services. The proposed services span a wide range of fields, including satellites, Internet of Things (IoT), ad hoc networks (such as sensor; vehicular; and aerial networks), gaming, and social networks. For each service, the paper illustrates the methods that would be used by cloud providers to offload the service data to the HAPS and enable the cloud customers to consume the service. The paper further sheds light on the challenges that need to be addressed for realizing practical cloud-enabled HAPS, mainly, those related to high energy, processing power, quality of service (QoS), and security considerations. Finally, the paper discusses some open issues on the topic, namely, HAPS mobility and message routing, HAPS security via blockchain and machine learning, artificial intelligence-based resource allocation in cloud-enabled HAPS, and integration with vertical heterogeneous networks.
The Path to an Evidence-Based Treatment Protocol for Extraoral Photobiomodulation Therapy for the Prevention of Oral Mucositis
Authors: Adnan Ather , Yaroslavsky Anna N. , Carroll James D. , Selting Wayne , Juliano Amy F. , London Wendy B. , Sonis Stephen T. , Duncan Christine N. , Treister Nathaniel S.
Published: July 2021

Oral mucositis is a painful complication of hematopoietic stem cell transplantation for which photobiomodulation therapy (PBMT) is a safe and effective intervention. Extraoral delivery of PBMT has clinical advantages over intraoral delivery but requires additional dosimetric considerations due to the external tissue layers through which the light must propagate before reaching the oral mucosa. Additionally, to date there has been no dose modeling study, a task essential to developing a justified treatment protocol. We review here some of the complexities surrounding extraoral photobiomodulation therapy and offer that may help guide researchers toward an evidence-based treatment protocol for the prevention of oral mucositis.
Impact Culture: Transforming How Universities Tackle Twenty First Century Challenges
Authors: Reed Mark S. , Fazey Ioan
Published: July 2021

New ways of doing research are needed to tackle the deep interconnected nature of twenty first century challenges, like climate change, obesity, and entrenched social and economic inequalities. While the impact agenda has been shaping research culture, this has largely been driven by economic imperatives, leading to a range of negative unintended consequences. Alternative approaches are needed to engage researchers in the pursuit of global challenges, but little is known about the role of impact in research cultures, how more or less healthy “impact cultures” might be characterized, or the factors that shape these cultures. We therefore develop a definition, conceptual framework, and typology to explain how different types of impact culture develop and how these cultures may be transformed to empower researchers to co-produce research and action that can tackle societal challenges with relevant stakeholders and publics. A new way of thinking about impact culture is needed to support more societally relevant research. We propose that healthy impact cultures are: (i) based on rigorous, ethical, and action-oriented research; (ii) underpinned by the individual and shared purpose, identities, and values of researchers who create meaning together as they generate impact from their work; (iii) facilitate multiple impact sub-cultures to develop among complementary communities of researchers and stakeholders, which are porous and dynamic, enabling these communities to work together where their needs and interests intersect, as they build trust and connection and attend to the role of social norms and power; and (iv) enabled with sufficient capacity, including skills, resources, leadership, strategic, and learning capacity. Based on this framework we identify four types of culture: corporate impact culture; research “and impact” culture; individualistic impact culture; and co-productive impact culture. We conclude by arguing for a bottom-up transformation of research culture, moving away from the top-down strategies and plans of corporate impact cultures, toward change driven by researchers and stakeholders themselves in more co-productive and participatory impact cultures that can address twenty first century challenges.
Upcycling of Wastewater Sludge Incineration Ash as a 3D Printing Technology Resource
Authors: Ki Dongwon , Kang Shin Young , Park Kwang-Min
Published: July 2021

Recycling of usable resources from waste must be prioritized to adhere to the circular economy policy implemented worldwide. This study aims to use wastewater sludge incineration ash (WSIA), which is a by-product of wastewater sludge treatment processes, in the 3D printing industry as a sustainable material. First, we explored the stability of incinerated ash generated from a wastewater treatment facility in Seoul by evaluating its physical (water content, organic matter content, and particle size) and chemical (oxide compound composition) characteristics. Composition ratios of the predominant oxides of silicon (SiO2), aluminum (Al2O3), phosphorous (P2O5), iron (Fe2O3), and calcium (CaO) were stable for 6 months. This finding indicates the potential for the incinerated ash to be commercially viable as a powder-bed 3D printed geopolymer. We then examined the optimal ratio of admixtures between the incinerated ash and ultrarapid hardening cement and the following post-treatment process method as a curing stage. The composite material made with 25% WSIA exhibited stability during the curing stage using alkaline solutions, and its compressive strength and water absorption were in accordance with the values recommended by the Korean Standard for decorative concrete blocks (KS F 4038). Additionally, a geopolymer prototype with 25% incinerated ash was produced. To support efficient upcycling of WSIA, long-term environmental and functional monitoring of the final product, effects of incinerated ash particle sizes, and post-treatment process times were further investigated to reduce costs.
Promoting Exercise and Healthy Diet Among Primary Care Patients: Feasibility, Preliminary Outcomes, and Lessons Learned From a Pilot Trial With High Intensity Interval Exercise
Authors: Smith-Ryan Abbie E. , Weaver Mark A. , Viera Anthony J. , Weinberger Morris , Blue Malia N.M. , Hirsch Katie R.
Published: July 2021

Physical activity and healthy diet are recognized as effective approaches for disease prevention. Controlled laboratory clinical trials support these approaches, yet minimal data exists supporting implementation of exercise as medicine within a healthcare setting.

Objectives: To understand perception and barriers to exercise and nutrition from patients and physicians from a family medicine clinic (FMC) to inform the implementation of a laboratory-based exercise and nutrition lifestyle intervention (Phase I), and to determine the feasibility, adherence, and preliminary outcomes of implementing this lifestyle intervention into a FMC (Phase II).

Methods: In phase I 10 patients and 5 physicians were interviewed regarding perceptions of exercise and nutrition practices. In phase II patients at risk for cardiovascular disease were enrolled into a lifestyle intervention (n = 16), within a FMC, manipulating diet and exercise. Cardiorespiratory fitness (CRF), body composition, and metabolic blood markers were completed at baseline, after the 12-week intervention, and at 24 weeks. Feasibility was defined by patients who completed the intervention and number of sessions vs. total available.

Results: Prescribing high-intensity interval training and a meal replacement for 12 weeks in patients with at least one risk factor for cardiovascular disease, was shown to have moderate feasibility with 62.5% (n = 10) for patients completing the 12 week intervention, and poor feasibility for assessing effects 12 weeks after cessation of the intervention, with 50% (n = 5) participants returning. Tracking exercise electronically via FitBit had moderate fidelity (n = 9), with hardcopy logs yielding poor compliance (n = 6). This pilot study demonstrated preliminary effectiveness of this home-based approach for improving cardiorespiratory fitness with an average 4.31 ± 5.67 ml·kg·min−1 increase in peak oxygen consumption. Blood triglycerides and insulin were improved in 70% and 60% of the patients, respectively.

Conclusions: Despite moderate feasibility, a home-based exercise and nutrition has the potential to be used as an effective approach for managing and mitigating cardiovascular disease risk factors. There were key lessons learned which will help to develop and adapt a larger scale lifestyle intervention into a clinical setting.

Clinical Trial Registration:https://clinicaltrials.gov/ct2/show/study/NCT02482922, identifier NCT02482922.
Oral Vaccination Reduces the Effects of Lawsonia intracellularis Challenge on the Swine Small and Large Intestine Microbiome
Authors: Leite Fernando L. , Winfield Brittanie , Miller Elizabeth A. , Weber Bonnie P. , Johnson Timothy J. , Sylvia Fred , Vasquez Erika , Vannucci Fabio , Beckler Dana , Isaacson Richard E.
Published: July 2021

Porcine proliferative enteropathy remains one of the most prevalent diseases in swine herds worldwide. This disease is caused by Lawsonia intracellularis, an intracellular bacterial pathogen that primarily colonizes the ileum. In this study, we evaluated changes to the microbiome of the ileal mucosa, ileal digesta, cecal digesta, and feces subsequent to challenge with L. intracellularis and to an oral live vaccine against L. intracellularis. Given that gut homogenates have been used since 1931 to study this disease, we also characterized the microbial composition of a gut homogenate from swine infected with L. intracellularis that was used as challenge material. The L. intracellularis challenge led to a dysbiosis of the microbiome of both the small and large intestine marked by an increase of pathobionts including Collinsella, Campylobacter, Chlamydia, and Fusobacterium. This microbiome response could play a role in favoring L. intracellularis colonization and disease as well as potentially predisposing to other diseases. Vaccination altered both small and large intestine microbiome community structure and led to a significant 3.03 log10 reduction in the amount of L. intracellularis shed by the challenged pigs. Vaccination also led to a significant decrease in the abundance of Collinsella, Fusobacterium, and Campylobacter among other microbial changes compared with non-vaccinated and challenged animals. These results indicate that L. intracellularis infection is associated with broad changes to microbiome composition in both the large and small intestine, many of which can be mitigated by vaccination.
Prognostic Signature of Osteosarcoma Based on 14 Autophagy-Related Genes
Authors: Qi Wei , Yan Qian , Lv Ming , Song Delei , Wang Xianbin , Tian Kangsong
Published: July 2021

Background:Osteosarcoma is a common malignancy of bone with inferior survival outcome. Autophagy can exert multifactorial influence on tumorigenesis and tumor progression. However, the specific function of genes related to autophagy in the prognosis of osteosarcoma patients remains unclear. Herein, we aimed to explore the association of genes related to autophagy with the survival outcome of osteosarcoma patients.

Methods:The autophagy-associated genes that were related to the prognosis of osteosarcoma were optimized by LASSO Cox regression analysis. The survival of osteosarcoma patients was forecasted by multivariate Cox regression analysis. The immune infiltration status of 22 immune cell types in osteosarcoma patients with high and low risk scores was compared by using the CIBERSORT tool.

Results:The risk score model constructed according to 14 autophagy-related genes (ATG4A, BAK1, BNIP3, CALCOCO2, CCL2, DAPK1, EGFR, FAS, GRID2, ITGA3, MYC, RAB33B, USP10, and WIPI1) could effectively predict the prognosis of patients with osteosarcoma. A nomogram model was established based on risk score and metastasis.

Conclusion:Autophagy-related genes were identified as pivotal prognostic signatures, which could guide the clinical decision making in the treatment of osteosarcoma.
SU2-NEMO: An Open-Source Framework for High-Mach Nonequilibrium Multi-Species Flows
Authors: Maier Walter T. , Needels Jacob T. , Garbacz Catarina , Morgado Fábio , Alonso Juan J. , Fossati Marco
Published: July 2021

SU2-NEMO, a recent extension of the open-source SU2 multiphysics suite’s set of physical models and code architecture, is presented with the aim of introducing its enhanced capabilities in addressing high-enthalpy and high-Mach number flows. This paper discusses the thermal nonequilibrium and finite-rate chemistry models adopted, including a link to the Mutation++ physio-chemical library. Further, the paper discusses how the software architecture has been designed to ensure modularity, incorporating the ability to introduce additional models in an efficient manner. A review of the numerical formulation and the discretization schemes utilized for the convective fluxes is also presented. Several test cases in two- and three-dimensions are examined for validation purposes and to illustrate the performance of the solver in addressing complex nonequilibrium flows.
Growth of Basil (Ocimum basilicum) in Aeroponics, DRF, and Raft Systems with Effluents of African Catfish (Clarias gariepinus) in Decoupled Aquaponics (s.s.)
Authors: Pasch Johannes , Appelbaum Samuel , Palm Harry Wilhelm , Knaus Ulrich
Published: July 2021

Basil (Ocimum basilicum) was cultivated in three hydroponic subsystems (i) a modified commercial aeroponics, (ii) a dynamic root floating (DRF) system, and (iii) a floating raft system in a decoupled aquaponic system in Northern Germany, Mecklenburg–Western Pomerania. For plant nutrition, aquaculture process water from intensive rearing of African catfish (Clarias gariepinus) was used without fertilizer. After 39 days, 16 plant growth parameters were compared, with aeroponics performing significantly better in 11 parameters compared with the DRF, and better compared with the raft in 13 parameters. The economically important leaf wet and dry weight was over 40% higher in aeroponics (28.53 ± 8.74 g; 4.26 ± 1.23 g), but similar in the DRF (20.19 ± 6.57 g; 2.83 ± 0.90 g) and raft (20.35 ± 7.14 g; 2.84 ± 1.04 g). The roots in the DRF grew shorter and thicker; however, this resulted in a higher root dry weight in aeroponics (1.08 ± 0.38 g) compared with the DRF (0.82 ± 0.36 g) and raft (0.67 ± 0.27 g). With optimal fertilizer and system improvement, aquaponic aeroponics (s.s.) could become a productive and sustainable large-scale food production system in the future. Due to its simple construction, the raft is ideal for domestic or semi-commercial use and can be used in areas where water is neither scarce nor expensive. The DRF system is particularly suitable for basil cultivation under hot tropical conditions.
Antibiotic Prescriptions for Respiratory Tract Viral Infections in the Colombian Population
Authors: Machado-Duque Manuel E. , García Diego Arturo , Emura-Velez Melissa Hiromi , Gaviria-Mendoza Andrés , Giraldo-Giraldo Claudia , Machado-Alba Jorge E.
Published: July 2021

Antimicrobials are frequently inappropriately prescribed for the management of upper respiratory tract infections (URTIs); therefore, the frequency of antibiotic prescriptions for patients with viral URTIs was assessed in this study. A cross-sectional study, including ambulatory patients diagnosed with viral URTI, was conducted, and records of antimicrobial prescriptions were obtained. Sociodemographic, clinical (diagnostic), and pharmacological (antimicrobial) variables were assessed. Through multivariate analysis, variables associated with the use of antibiotics for viral infections were identified. A total of 341,182 patients with viral URTIs were identified. The patients, who were from 26 different departments of Colombia, had a mean age of 29.7 ± 23.5 years and a female predominance of 58.7% (n = 200,195). The most frequent viral infections were as follows: acute rhinopharyngitis (common cold) (n = 206,211; 60.4%); unspecified acute tonsillitis (n = 27,432; 8.0%); and acute pharyngitis (n = 26,411; 7.7%). A total of 24.8% of the patients (n = 84,453) received a prescription for antibiotics, predominantly penicillins (n = 61,871; 18.1%) and cephalosporins (n = 10,926; 3.2%). Patients treated in Atlántico, Valle, and Risaralda departments, along with those older than 5 years, were more likely to receive antibiotics for the treatment of viral infections. Antibiotics are frequently prescribed for the management of URTIs, which is considered an inappropriate practice due to a lack of clinical benefits, increased generation of antimicrobial resistance, and a risk of adverse reactions due to the use of medications that patients do not require. Drug utilization studies are a great tool for monitoring how antibiotics are being used and planning interventions to improve their use.