bluuebunny/crossref_metadata_2025 huggingface dataset:
Emotional state and illness perception of patients with cardiac rhythm disorders during preparation for fast-track surgical treatment
Authors:   St. Petersburg State University, Shchelkova Olga , Yakovleva Maria ,   St. Petersburg State University, Provotorova Julia ,   St. Petersburg State University, Sheremet Anton ,   St. Petersburg State University, Zubarev Evgeny ,   St. Petersburg State University, Kamenskikh Maksim ,   St. Petersburg State University, Efremov Sergey ,   St. Petersburg State University, Shmatov Dmitry ,   St. Petersburg Research Institute of Phthisiopulmonology
Published: February 2025

The relevance of the study is determined by the need to study the emotional state and illness perception of patients with cardiac arrhythmias in order to determine the main guidelines of psychological preparation for high-tech cardiac surgery and of psychological support in the early postoperative period. The study sample consisted of 77 patients with cardiac rhythm disorders (mean age 57.09 ± 13.6 years; 44.2 % male) referred for fast-track radiofrequency ablation during their brief hospital stay. Patients’ emotional state, illness perception and their relationship were studied by means of a structured interview, a questionnaire for the physician and three psychometric methods (Depression, Anxiety and Stress Scale DASS-21, Perceived Stress Scale PSS-10, Brief Illness Perception Questionnaire BIPQ). The results of the study showed a predominance of anxiety symptoms in the structure of patients’ emotional state compared to depression symptoms, as well as higher values of the scales of anxiety (p = 0.000), stress (p = 0.000), general index (p = 0.001) of the DASS-21 and the stress index (p = 0.000) of the PSS-10 compared to normative data. The cognitive, emotional, motivational and behavioural components of illness perception were studied. It was revealed that the majority of patients have a fairly clear idea of their disease and the upcoming surgery, while awareness of the course of the postoperative period is insufficient in the vast majority of patients (83.1 %), which gives a reference point for preparing patients for surgery. In the structure of illness perception, the highest relevance is given to the scores of the BIPQ scales “Concern” and “Understanding”. Correlation analysis revealed relationships between the indicators of negative emotional states (depression, anxiety, stress) and the indicators of the BIPQ scales included in the factor “Perception of threat of illness”. In the preoperative period, a high level of adherence to drug therapy and a significantly lower level of adherence to a recommended lifestyle was found. Prospects for an observational study of the psychological status of patients after surgery are outlined.
Managing sanitation in unplanned urban areas: insights into manual emptying of onsite systems in Tandale, Dar es Salaam
Authors: Stephen Anna , Kimwaga Richard , M. M. Mulungu Deogratius , Izdori Fides
Published: February 2025

Achieving Sustainable Development Goal 6.2 in unplanned urban settlements seems to be a challenge due to climate variability and population growth, which strain existing sanitation services. The study found out that all residents of Tandale rely on on-site sanitation facilities, with 70.8% using pit latrines, 27.1% using septic tanks, and the remainder utilizing eco-friendly options like Aqua privies (0.3%) and Eco-san (1.8%). Emptying is necessary as space is limited for digging new pits. About 52.4% of households use vacuum trucks, while manual emptying remains a significant practice at 24.9%, with 5.7% of residents discharging waste directly into drains and 17.0% never emptying their latrines. The high water table, narrow streets, and limited resources further complicate sanitation efforts, while climate variability, particularly flooding, exacerbates pit overflows and increases health risks. Additionally, the 9.19 km distance to the disposal site and uneven terrain hinder the feasibility of simplified sewers or gravity-based systems. Recognizing the impracticality of eliminating manual emptying, this study recommends that manual emptiers should be empowered to provide safer and more efficient services. Integrating Decentralized Wastewater Treatment Technology (DEWATT) with improved Manual Emptying Technology (MAPET) will offer a locally affordable and sustainable solution.
IMPLEMENTAÇÃO DA EDUCAÇÃO INTEGRAL A PARTIR DO MODELO DE EDUCAÇÃO EM TEMPO INTEGRAL NO CENTRO MUNICIPAL DE EDUCAÇÃO INFANTIL DE SANTANA DO MATOS R/N
Authors: Lopes Jeane Cristina Rodrigues , Santos Geovar Miguel dos
Published: February 2025

A Educação Integral em Tempo Integral tem sido um dos principais temas discutido na atualidade, haja visto o incentivo do Governo Federal, devido a meta 6 do Plano Nacional da Educação (PNE). Este trabalho tem como enfoque Educação Integral em Tempo Integral na etapa da Educação Infantil em uma instituição pública de Santana do Matos R/N. Tem por objetivo analisar o processo de implementação da Educação Integral em Tempo Integral no Centro Municipal de Educação Infantil (CMEI). Este trabalho tem uma abordagem qualitativa, e a metodologia se deu por uma pesquisa bibliográfica, e fez o uso da técnica de entrevista estruturada, como instrumento de coleta de dados. Para fundamentar as ideias aqui debatidas, usamos os escritos de Gadotti (2009), Costa (2021) e Severino (2013). Assim, concluímos que a complexidade na implementação da Educação Integral em Tempo Integral vai além de mera mudança estrutural, exigindo preparo técnico-político e a formação contínua. Por mais que sua expansão enfrente desafios estruturais, o comprometimento com as metas educacionais aponta para um caminho promissor para o desenvolvimento integral dos alunos, o que demanda esforços coordenados, investimentos e adaptações ao longo do tempo.
SOCIAL PHENOMENON OF DISCRIMINATION IN THE FIELD OF LABOR IN THE CONTEXT OF DIGITALIZATION OF PUBLIC LIFE
Authors:   Penza State University, I. Naydenova Lyudmila , S. Tarkhanova Elena ,   Penza State University
Published: February 2025

Background. Under the modern social and economic conditions, the problem of discrimination initially caused by the transition to market relations takes on new forms and leads to new consequences in the context of informatization and digitalization of Russian society. This problem requires examination to develop relevant recommendations for overcoming discrimination and its consequences. The aim is to study the manifestations of discrimination in the field of labor relations in modern conditions. Particular attention is paid to the analysis of digital discrimination; new possible types of social stratification based on digital inequality in the sociological aspect are identified. Materials and methods. To achieve this aim, a systematic approach is used to review and analyze various aspects of the problem under study in the Russian and foreign literature; the results of sociological surveys in the relevant field analyzed. The methods of comparison and generalization of statistical indicators are also used to identify the most significant features and various aspects of the problem under study in the conditions of informatization and digitalization of society. Results. Statistical data and various studies of discrimination in the field of labor are reviewed. The types of discrimination in the field under study are systematized. The trends in the manifestation of social professional and gender differences associated with informatization and digitalization of society are characterized. A separate part is devoted to studies of the impact of digital technologies on the labor field, which leads to the emergence of a new type – digital discrimination. The signs of digital inequality in access to information and work with it are highlighted. The vector for further studies in this field is determined. Conclusions. The social phenomenon of discrimination by gender, age, and education is presented as a manifestation of social inequality in labor relations. It is noted that in the context of informatization of society and digitalization of economic sectors and many aspects of public life, an already recognized digital inequality has appeared, which creates the basis for a new one – social, economic and legal inequality with manifestations of discrimination. It leads to the emergence of signs of social informational stratification, complementing social stratification, which determines new directions for further studies.
ON THE CONCEPT OF LEGAL RELATIONS RELEASING FROM LEGAL LIABILITY
Authors:   Tolyatti State University, S. Kuzmin Dmitry
Published: February 2025

Background. The relevance of examining the legal relations of legal liability is predetermined by both theoretical and legal factors. Firstly, the analysis shows that scientific papers mainly focus on protective legal relations and such a variety as legal relations of legal liability. As a result, there is an imbalance in the phenomena studied in science, which cannot have a positive effect on le-gal practice, the effectiveness of which largely depends on the results of legal science. Secondly, legal practice, including legislative activity, does not often distinguish such phenomena as release from liability and exemption of legal liability, which cannot positively affect the state of law and order. The aim of this study is to identify specific features of legal relations that release from legal liability. Materials and methods. In the study, such methods as dialectical and formal legal methods, methods of analysis and synthesis, deduction and induction, as well as algorithms peculiar to research of paired legal categories are used. Results. The definitions of the concepts of “legal relations”, “legal relations of legal liability” and “legal relations releasing from legal liability” are compared, the essential features of legal relations releasing from legal liability necessary to formulate the definition of this concept are revealed. The study suggests that legal relations of legal liability can be implemented without the participation of the state on a voluntary basis and that the concepts of “release from legal liability” and “release from punishment” should be differentiated. Conclusions. The dualistic nature of several legal relations that release from legal liability is determined. The author formulates the definition of the concept under study.
ADMINISTRATIVE MEASURES IN THE FIELD OF COUNTERING TERRORISM IN RUSSIA AND ABROAD
Authors:   Penza State University, G. Romanovsky Vladislav
Published: February 2025

Background. Terrorism is a global threat that requires extraordinary countermeasures. Taking into account the fact that the main task of the state in this field is to prevent terrorist attacks, various administrative measures aimed at preventing criminal acts are increasingly in demand. The main aim is to study foreign practices of introducing administrative measures in the field of countering terrorism and preventing manifestations of terrorism. Materials and methods. The empirical basis of the study is made up of various foreign acts, among which the Internal Security Act of Singapore dated July 27, 1960 No. 18, Law of the French Republic dated October 30, 2017 No. 2017–1510 “Strengthening national security and combating terrorism” and Terrorism Prevention and Investigation Measures Act 2011 of the United Kingdom Act should be highlighted. The main research method is comparative legal, which allows transferring the foreign practices into Russian law-making practice. Results. The main conclusion is to determine the effectiveness of legislative acts that establish administrative measures against persons in respect of whom there are sufficient grounds for suspicion of involvement in terrorist activity. The main objective of such measures is terrorism prevention, identification of persons suspected of involvement in terrorist activity and their social rehabilitation. Conclusions. The article substantiates the need to establish registers of preventive records of persons suspected of involvement in terrorist activity and to introduce administrative control measures that provide for certain restrictions on the fundamental human and civil rights and freedoms.
CONTENT AND DISTRIBUTION OF HEAVY METALS (ZINC, COPPER, LEAD AND CADMIUM) IN PEAT SOILS OF DRAINED MARSHES OF THE KIROV REGION
Authors:   Vyatka State Agrotechnological University, Novosyolova E.S.
Published: February 2025

Data on the content and distribution of some heavy metals (zinc, copper, lead and cadmium) in the soil layer of drained and anthropogenically transformed marshes of the central part of the Kirov region are presented. Studies were carried out in 2011–2016 on two drained marshes: “Zenginskoye” and “Karinskoye”. Studies have shown that the content of total and mobile forms of heavy metals in the peat of the surveyed marshes is insignificant and in general does not exceed the known standards of maximum permissible concentrations and the average background content in zonal sod-podzolic soils of the Kirov region. The involvement of drained marshes in economic activity leads to an increase in the content of heavy metals in the soil profiles of drained marsh soils. In areas occupied by crops and plantings of P. sylvestris and P. abies, the content of heavy metals is higher compared to the control area: zinc – by 5–18 times, copper – by 6–24 times, lead – by 2–4 times, and cadmium – by 3–5 times. Residual peat layers contain insignificant reserves of heavy metals. The residual peat of the Zenginskoye marsh contains significantly more heavy metals than the peat of the Karinsky massif. The content of heavy metals in the residual peat layers of these objects does not pose a danger to the environment with the possible subsequent involvement of drained bog biogeocenoses in agricultural and forestry use.
Characterization of Plant Pathogenic Bacteria Causing Crown Rot Disease in Papaya (Carica papaya L.)
Authors: Rania Khansa Diva , Aini Luqman Qurata
Published: February 2025

Papaya (Carica papaya L.) is an annual plant belonging to the Caricaceae family. Papaya populations in Indonesia can be found in almost all regions. The extensive papaya cultivation areas in Indonesia often involve planting on wild land, which exposes papaya plants to various diseases. Crown rot disease is an example of a disease in papaya. Papaya plantations in Jajag, Gambiran, Banyuwangi Regency, are known to be affected by stem rot. To determine the appropriate disease control measures, it is necessary to identify the cause of the wet rot disease in papaya plant stems. The research was conducted through several stages, including sampling, media preparation, isolation of pathogenic bacteria, hypersensitivity tests, pathogenicity tests, potato soft rot tests, colony and cell morphological observation, Gram staining, oxidative/fermentative, yellow colony on YDC media, lecithinase, catalase, sensitivity to erythromycin, carbohydrate fermentation, and temperature treatment at 37°C and 40°C. The results showed that the plant pathogenic bacteria causing crown rot at the base of the stem in papaya plants were isolates B1 and B2, belonging to the group of Pantoea sp.; isolates B3, B6, and B7, belonging to the group of Erwinia sp.; and isolates B4 and B5, belonging to the group of Dickeya sp..
The Role of Trichoderma sp. as a Biocontrol Agent in Suppression of Root Rot Disease and Soybean Plant Biostimulants
Authors: Maknunin Lu'lu'il , Abadi Abdul Latief , Choliq Fery Abdul
Published: February 2025

Domestic demand for soybeans continues to increase annually, but average production has declined. To meet national needs, the government must import soybeans. The low soybean production in Indonesia is attributed to pest disturbances, particularly root rot disease (Sclerotium rolfsii), which causes plant death. This study aims to contribute to the development of biological control technology to enhance soybean crop health and sustainability. The study employed a Completely Randomized Design (CRD) with five treatments and five replications. The results obtained were analyzed using ANOVA at a 5% significance level, and if significant differences were found, further tests were conducted using the 5% Tukey test. The application of Trichoderma species individually was effective in reducing the incidence and intensity of root rot disease caused by S. rolfsii and increasing the total phenolic compound levels in plants as an indicator of enhanced plant resistance. Meanwhile, the combination of Trichoderma species positively influenced the number of leaves in soybean plants.
Las Naciones Unidas y la normativa internacional frente al uso de la fuerza en guerras híbridas e irrestrictas
Authors: Rico Arenas José Luis , Cardona-Orozco Andrés Felipe
Published: February 2025

La caída del Muro de Berlín puso fin a la Guerra Fría y a la bipolarización de las relaciones internacionales, dejando atrás un enfrentamiento global controlado y abrió una puerta a numerosos conflictos locales descontrolados. Estos cambios generaron nuevas formas de amenazas como las híbridas, la guerra irrestricta y la revolución molecular disipada, las cuales se enmarcan en conflictos asimétricos, cuyo objetivo es el Estado. Frente al uso de diversos medios y diferentes tipos de armas, en diferentes escenarios, es claro que los Estados no cuentan con las suficientes herramientas jurídicas, policiales y militares en sus legislaciones, lo que representa una especial coyuntura en el desarrollo de políticas de seguridad y defensa.
The effects of a modified Mediterranean diet on gut microbiota and clinical outcomes in patients with metastatic colorectal cancer undergoing first-line chemotherapy with either anti-EGFR or anti-VEGF agent: protocol for a randomized pilot study (Preprint)
Authors: Artale Salvatore , Filiali Francesca , Beretta Elena , Arosio Francesca , Cazzaniga Federica , Tersalvi Carlo , Sofia Michele , Tagliabue Paola , Pozzi Paola , Colombo Andrea , Carbone Claudia , Pietrogiovanna Lisa , Verga Magda , Nova Paola , Calori Rossella , Renso Rossella , Rota Selene , Aglione Stefania , Manfrida Italo , Facendola Giovanna , Trojani Alessandra , Dazzani Maria Chiara , Basciani Sabrina , Valsecchi Maria Grazia , Capitoli Giulia , Cocola Cinzia , Consolandi Clarissa
Published: February 2025

BACKGROUND

the gut microbiota is attracting increasing interest as an initiator of colorectal cancer. It has been observed that microbial imbalance in the gut and in cancer tissue is facilitated by a Western type diet, rich in meat, sugars, and refined grains, while a Mediterranean diet, rich in low saturated fat and fibers, promotes gut eubiosis, and results in reduced risk of developing colorectal cancer.

OBJECTIVE

to analyze and compare the gut microbiota of patients with metastatic colorectal cancer undergoing first-line chemotherapy +/- a biological agent (anti-EGFR or anti-VEGF), and receiving either a free standard Western diet, or a modified Mediterranean diet.

METHODS

this is a pilot non-drug, interventional prospective, randomized, controlled, single-center, open-label trial. Patients (n=40) will be randomized 1:1 to either a modified Mediterranean diet or a free Western type diet. Blood and fecal samples will be collected at baseline and control visits, for metagenomic and metabolomic analysis. The primary endpoint is the Firmicutes/Bacteroidetes ratio after completion of the third cycle of first-line chemotherapy (time T1). Secondary endpoints are: a) the percentage of patients experiencing gastrointestinal side effects at T1; b) the percentage of patients experiencing grade 3/4 gastrointestinal side effects at T1; c) changes in the Firmicutes/Bacteroidetes ratio, overall microbiome composition, and metabolome at T1, and after the sixth chemotherapy cycle (T2) versus baseline.

RESULTS

this pilot trial has received ethics approval on July 24th 2024. By January 2025, 7 participants have been recruited. The study will conclude with the visit at T2 for the last enrolled patient. Results are expected to be published in October 2028.

CONCLUSIONS

this study has the potential to provide critical insights into the role of diet in modifying the gut microbiota, diminishing chemotherapy-related side effects, and possibly enhancing the therapeutic efficacy in metastatic colorectal cancer. Additionally, data may pave the way for future research in immunotherapy, potentially influencing both clinical practice and public health strategies.

CLINICALTRIAL

Clinicaltrial.gov NCT06794931 (https://clinicaltrials.gov/search?term=NCT06794931)
Politik Uang Dalam Dinamika Sosial Di Sumatera Barat Dan Implikasinya Terhadap Ketahanan Wilayah
Authors: Putra Eka Vidya , Fernandes Reno , Patra Haldi
Published: February 2025

This study aimed to explored the relationship between money politics and regional political in the context of changing social dynamics in West Sumatra, an area traditionally and religiously known for the philosophy of “Adat Basandi Syarak, Syarak Basandi Kitabullah”.                  This study used a survey method with a qualitative and quantitative analysis approach. Data were collected through a survey of 430 respondents in West Sumatra obtained through multiple random sampling and in-depth interviews with various stakeholders, including politicians, academics, and the general public.                 The results showed that although the majority of West Sumatran people still uphold customary and religious values, rapid social and economic changes had influenced their perceptions of money politics. These findings indicated an increasing acceptance of money politics as a strategy to achieved political power, which had implications for political resilience in West Sumatra. This study highlighted the importance of strengthening political education and democratic values that were in line with local traditions to maintained the integrity of the democratic process in West Sumatra.
A four-year serological survey of Leptospira spp. in stray dogs from northwest Mexico
Authors: Monge-Navarro Francisco Javier , Gaxiola-Camacho Soila Maribel , López-Valencia Gilberto , Trasviña-Muñoz Enrique , Castro-Del Campo Nohemí , Herrera-Ramírez José Carloman
Published: February 2025

The presence of stray dogs in a community represents a significant risk factor in the spread and maintenance of Leptospira by acting as pathogen reservoirs and potentially transmitting the bacteria to household dogs and the peri-domestic environment, increasing the risk of zoonotic transmission of the disease. Here, we utilized an indirect ELISA employing recombinant LipL32 protein to detect IgG antibodies to Leptospira in serum samples from stray dogs in Mexicali, Northwest Mexico. Serum samples (n = 331) from stray dogs were collected from 2017 to 2020 and tested with the ELISA-LipL32. The results showed an overall seroprevalence of 46.52 % (154/331) over the four years, 46.36 % (51/110) in 2017, 57.95 % (51/88) in 2018, 28.85 % (15/52) in 2019, and 45.68 % (37/81) in 2020. The high prevalence of serum antibodies to Leptospira among the stray dog population indicates that Mexicali provides optimal ecological conditions for maintaining and disseminating leptospire throughout the city, increasing the risk of infection to other domestic or companion animals and the human population. Further epidemiological research is necessary to identify the serovars in the region and propose strategies to control the stray dog population and the propagation of Leptospira in the Northwest region of Mexico.
¿Cápsulas con virus? Una nueva forma de combatir a Pseudomonas aeruginosa en la fibrosis quística pulmonar
Authors: García-González Gerardo , Martínez-Flores Patricia , García Joselyn , Encinas Basurto David Armando , Juárez Josué , Rodea-Montealegre Gerardo Erbey , Quihui-Cota Luis , López-Mata Marco Antonio
Published: February 2025

La Fibrosis Quística Pulmonar (FQP) es una enfermedad que se caracteriza por la producción excesiva de moco, el cual suele obstruir y dificultar el proceso respiratorio. Lo anterior crea un nicho propicio para el desarrollo de infecciones bacterianas, que junto con la respuesta inflamatoria provoca una pérdida progresiva de la función pulmonar. Aunque la antibioticoterapia es el tratamiento recomendado para la FQP, la acción bactericida de estos compuestos se ve limitada debido a la matriz moco-biopelícula generada por el hospedero y el patógeno, respectivamente. Si a lo anterior se le suma la resistencia de las bacterias a los antibióticos, nos encontramos con una suma de factores que no abonan en la recuperación de los pacientes con FQP. Por lo anterior, el presente artículo aborda la situación de la FQP y algunas perspectivas sobre los posibles tratamientos basados en el uso de biomateriales, con propiedades mucolíticas (alginato) y mucoadhesivas (quitosano), como matriz de soporte, transporte y liberación de bacteriófagos viables-específicos contra Pseudomonas aeruginosa.
"It's mostly a one-way street, to be honest": the subjective relevance of public engagement in the science communication of professional university communicators
Authors: Biermann Kaija , Banse Lennart , Taddicken Monika
Published: February 2025

This study explores the subjective relevance and challenges of public engagement (PES) in science communication among professional university communicators based on 29 qualitative interviews in one German federal state. Despite recognizing its value, interviewees reveal significant uncertainties in understanding, objectives, and implementation of PES. They cite barriers such as reliance on scientists and control concerns. Surprisingly, social media is rarely considered for PES, with online engagement seen as difficult. This research highlights the complexities and challenges of PES in practice, emphasizing opportunities for optimized digital science communication strategies and clearer role structures between professionals and researchers to enhance PES.
Tabaco y jurisdicción. El gobierno del estanco del tabaco en el Nuevo Reino de Granada (1744-1812)
Authors: Torres Güiza Johan Sebastián
Published: February 2025

En la última década la historiografía ha destacado el gobierno jurisdiccional como un elemento crucial para entender el funcionamiento de los erarios regios indianos. Este enfoque ha superado las tradicionales interpretaciones administrativas y ha revelado a las instituciones fiscales como tribunales especializados responsables de la recaudación, la administración y la distribución de las rentas, así como de la supervisión contable y la lucha contra el fraude y el contrabando.

Tabaco y jurisdicción. El gobierno del estanco del tabaco en el Nuevo Reino de Granada (1744-1812) se inserta en el marco de una renovada visión de las reformas borbónicas implementadas en el siglo XVIII. La obra revela la jurisdicción especial de hacienda que gobernó este estanco, sin olvidar los otros (aguardiente, naipes y pólvora), los diversos jueces y tribunales involucrados, así como el papel jurisdiccional de la contabilidad en su gestión. A través de cuatro capítulos ordenados cronológicamente, el libro aborda tres dimensiones clave: la geografía económica, que muestra cómo las zonas productoras de tabaco estaban conectadas con los centros de consumo mediante rutas fluviales y caminos de arriería; la administración del estanco, que pasa de una estructura fragmentada a una red compleja de factorías, administraciones, tercenas, estanquillos y reales fábricas; y una perspectiva temporal amplia, que analiza las continuidades y transformaciones del estanco antes y después de la visita general del regente Francisco Gutiérrez de Piñeres por parte de la Corona hispánica.

Así pues, esta obra ofrece un cuestionamiento profundo sobre el denominado reformismo borbónico en el monopolio del tabaco en el Nuevo Reino de Granada entre 1744 y 1812, sustentado en documentación cualitativa y cuantitativa de archivos históricos colombianos y españoles.
Raíces profundas. Un viaje por las fuentes geohistóricas hasta la Ilustración
Authors: Camarero Bullón Concepción , Gómez Navarro María Soledad , Fernández-Arroyo López-Manzanares Alfonso , Bernabé Crespo Miguel Borja
Published: February 2025

Las fuentes geohistóricas, entre las que se encuentran las de tipo catastral y paracatastral, poseen generalmente una heterogeneidad y variedad tipológica mayor que en sus versiones actuales. Así pues, la investigación con fuentes geohistóricas, abordada desde múltiples disciplinas (Geografía, Historia, Arte, Antropología, Ciencias ambientales, Urbanismo, Arquitectura, Demografía...) supone un gran impulso para el análisis, el conocimiento y el estudio del territorio, de los paisajes y de la sociedad desde una perspectiva espaciotemporal.
Esta publicación con el título Raíces profundas. Un viaje por las fuentes geohistóricas hasta la Ilustración nace del I Congreso Internacional de Fuentes Geohistóricas: territorio y sociedad en el tiempo se centrará en temáticas de relevancia: la aplicación de este tipo de fuentes en estudios de tipologías variadas; las aportaciones metodológicas o la generación de estándares de trabajo aplicables a fuentes de tipo catastral y paracatastral de distintos ámbitos y épocas; la didáctica en torno a fuentes geohistóricas; la promoción de estas fuentes a través del uso de nuevas tecnologías en el ámbito de las Humanidades y las Ciencias Sociales; el estudio y análisis de documentación catastral, paracatastral, estadística y cartográfica cuyo objetivo sea conocer las características de las propias fuentes y sus contenidos, etcétera.
En definitiva, este encuentro científico u su posterior publicación en colaboración con las editoriales de la Universidad de Cantabria y la Universidad Autónoma de Madrid tiene el objetivo de servir de plataforma para los investigadores y técnicos que estén desarrollando aproximaciones sobre cuál es la finalidad de cada fuente, qué circunstancias ideológicas, políticas, sociales y económicas las motivaron, para qué pueden utilizarse hoy sus contenidos, qué datos se recogen y con qué criterios se agregan y elaboran, qué documentos se confeccionan directa e indirectamente y, finalmente, con qué medios humanos, con qué técnicas se levantaron y con qué recursos técnicos, humanos y de contexto se desarrollaron.
Synergistic antitumor activity of azacitidine and ubenimex on acute myeloid leukemia cells
Authors: Chen Can , Huang Yongfen , Zhang Linlin , Zhou Meilin , Xu Ya , Lu Jinbo , Cheng Yuexin , Miao Yuqing
Published: February 2025

Acute myeloid leukemia (AML) is a malignancy with high mortality rate
and a poor prognosis. Despite advances in targeted agents, effective
treatment of AML remains a major clinical challenge. Azacitidine (5AZA)
induces apoptosis and has been shown to be therapeutically effective in
AML. Ubenimex (Ube), an Aminopeptidase N (APN)/CD13 inhibitor, has
demonstrated antitumor activity in solid tumors and hematologic
malignancies. This study investigated the antitumor effects of 5AZA
combined with Ube in AML using CCK-8, cell apoptosis assay, cell cycle
assay, and western blot, as well as in vivo. The results showed that the
combination of 5AZA and Ube had a synergistic impact in suppressing the
proliferation and inducing apoptosis of AML cell lines compared to the
control group. In addition, the expression level of Bax was increased,
whereas the expression levels of Bcl-2, p-PI3K and p-AKT were decreased.
These effects were found to be reversible by the PI3K specific agonist
740Y-P.
Driving Mechanisms of Imbalance in Key Ecosystem Services in Dust Storm-prone Areas: A Case Study of the Hotan Oasis
Authors: Yu Shiqi , Zhang Zhaohui
Published: February 2025

The balance between supply and demand of ecosystem services (ESs) is the
cornerstone for maintaining regional socio-ecological system stability
and preventing land degradation. However, current research on the
driving mechanisms of ESs mostly focuses on the supply side, and the
driving mechanisms of supply-demand balance have not been sufficiently
emphasised. Taking the Hotan Oasis as the research region, we measured
the ecosystem services supply-demand ratios (ESDR) of four key services,
including sand fixation (SF), water yield (WY), soil retention (SR), and
food production (FP) in the Hotan Oasis from 2005 to 2020. We utilised
the optimal parameter-based geographic detector (OPGD) model to explore
the driving mechanisms for the four ESDRs. The results show that: (1)
the supply and demand of ESs showed significant spatial and temporal
variations; SF and SR were generally in deficit, with SF deficit areas
mainly distributed in the northern desert zone and SR deficit
concentrated in the southern mountainous areas. WY and FP had
quantitative surpluses, but spatial mismatches were prominent; (2)
Natural and human activities jointly drove the supply and demand of ESs.
Animal husbandry had a higher driving effect on SF, and its interaction
with natural factors was significant; Natural factors had the strongest
driving effect on ESDRs in WY and SR; the planting industry had the
strongest driving effect on FP, and its interaction with population
factors was prominent. (3) Aiming at the spatial heterogeneity of the
supply and demand of ESs and the driving mechanism, this study proposed
a zonal management framework of “source sand control - pathway blocking
- system synergy”.
Prediction of type 2 diabetes using support vector machine with enhanced levy flight based Fruitfly optimization algorithm and feature selection approaches
Authors: Kumar Ashok , Arputharaj Vijay , Sathya V. , Kumar Dalvin , Sundararajan Shanmugam , Sivanantham V. , Kumar Pal
Published: February 2025

Researchers have been leveraging various data analytics methods for Diabetes
mellitus (DM) diagnosis, prognosis and management. The data analytics
paradigm has become advanced and automated with the emergence of machine
learning (ML) and deep learning (DL) algorithms. With new techniques, the
prediction accuracy of ML models for various real-world problems has
increased significantly. In our previous work, we introduced and
investigated the Improved K-Means with Adaptive Divergence Weight Binary Bat
Algorithm to create an innovative diagnosis system. Across several problem
scenarios, the performance of this algorithm is much better in terms of
speed. However, this algorithm's accuracy of data categorization comes below
expectations. To achieve high classification accuracy, the objective of this
study work is to concentrate on methods and strategies. This aim is
fulfilled through a Support Vector Machine (SVM) with an Enhanced Levy
Flight-based Fruitfly Optimization model. This novel model improves diabetes
prediction accuracy and can be applied to regressions, classifications, and
other tasks. The nearest training data points? distances should be greater
as this can lower classifiers? generalization errors. Missing values in
datasets are retrieved using the Adaptive Neuro Fuzzy Inference System
(ANFIS). A new algorithm called the Enhanced Inertia Weight Binary Bat
Algorithm (EIWBBA) is introduced to optimize feature spaces and eliminate
unimportant aspects. Further on, a novel feature selection technique is
introduced by using the Enhanced Generalized Lambda Distribution Independent
Component Analysis (EGLD-ICA). The classification uses a Support Vector
Machine with an Enhanced Levy flight-based Fruitfly Optimization Algorithm
(SVM-ELFFOA). The SVM-ELFFOA classification techniques are implemented using
MATLsoftware. It is evident that the discussed IKM-EIWBBA+SVM-ELFFOA
classifier produces much better values of the accuracy of 93.50%, while the
available IKM-EIWBBA+SVM yields 91.87%, IKM-ADWFA+LR renders 90.50%, and
IKM+LR renders just 85.00%. From the simulation experiment, the proposed
classification techniques implemented in MATLsoftware and according to
comparative data, this suggested model has a higher prediction accuracy of
93.50% compared to existing classification methods.
Caracterización limnológica de la red de embalses del Consorcio de Aguas Bilbao Bizkaia
Authors: Llorente Alfredo , Fraile Henar
Published: February 2025

Este trabajo llevó a cabo la caracterización limnológica de los ocho principales embalses de abastecimiento gestionados por el Consorcio de Aguas Bilbao Bizkaia. Considerando el periodo 2017-2023, se analizaron variables ambientales categorizadas en composición iónica, variables hidromorfológicas, nutrientes principales y estado trófico. También se evaluaron las comunidades fitoplanctónicas, con especial atención al grupo de las cianobacterias. Por una parte, se detectaron diferencias entre los embalses en términos de composición iónica, características morfométricas y gestión hídrica. Por otra parte, la concentración de nutrientes esenciales y los indicadores del desarrollo algal no mostraron diferencias relevantes entre los embalses y se reportaron condiciones oligotróficas en todos los casos. Aunque las comunidades fitoplanctónicas compartieron similitudes, el biovolumen de especies agrupado en categorías taxonómicas y funcionales destacó las particularidades de la sucesión ecológica. Adicionalmente, los taxones sin agrupar revelaron diferencias entre las comunidades de los embalses pertenecientes a la cuenca norte (Unidad Hidrológica del Ibaizabal-Nervión) y aquellas pertenecientes a los embalses de la vertiente mediterránea (Sistema Zadorra). Estas diferencias se enfatizaron al considerar exclusivamente el grupo de las cianobacterias que presentó especies con una distribución específica en cada grupo geográfico. Este trabajo constituye la descripción ecológica más detallada de la que se tiene conocimiento para estos embalses y contribuye a la optimización de la red local de seguimiento ambiental y a la armonización de criterios para el seguimiento futuro.
The Impact of The Group Discussion Dethod on Attitudes of Responsibility and The Indonesian Language Learning Process for Class IX
Authors: Utami Tiara Puji , Markhamah M
Published: February 2025

This research aims to define the impact or results of applying the group discussion method on the responsible attitudes of class XI students. This research also aims to define the influence of the group discussion method on students' learning understanding outcomes. The method used in this research is a qualitative descriptive method, using interviews and direct observation as the data collection process. The data obtained is then analyzed according to considerations and visible results. The learning process is an important thing in education, in the learning process students learn many new things that they do not yet have. In a learning process, students not only gain cognitive knowledge, but also affective abilities are taken into account. The group discussion method has a good impact on the student learning process in class, because by using the discussion method students are able to improve their ability to express their thoughts and socialize. The group discussion method also has an influence on students' responsible attitudes towards their group friends and themselves.
Values of Progressive Education in the Novel entitled "Anak-Anak Cahaya" by Ramaditya Adikara
Authors: Devikasari Fani , Markhamah M
Published: February 2025

Purpose: The purpose of this study is twofold: firstly, to analyze the educational values present in the novel "Anak-Anak Cahaya" (Children of Light) and secondly, to specifically examine the progressive educational values embedded within the narrative.
Methodology: The research method used is a qualitative descriptive approach. The data collection technique of this research is note-taking technique. The data source for this research is the novel Anak-Anak Cahaya by Ramaditya Adikara. The research data is the intrinsic elements and educational values contained in the novel. The technique of testing the validity of the research data is carried out by testing the credibility. The data analysis technique of this research is descriptive qualitative.
Results: The results of this study are the general educational values contained in the novel Anak-Anak Cahaya, namely religigious, honest, hard work, independent, friendly, social care, curiosity, love peace, and like to read. The novel Anak Anak Cahaya has educational values that are obtained based on the experiences of the characters. The values of progressive education in the novel Anak-Anak Cahaya are mutual helphave faith in Allah, mutual cooperation, and never give up.
Applications/Originality/Value: Educational values contained in the novel Anak-Anak Cahaya, namely religious, honest, hard work, independent, friendly, social care, curiosity, love peace, and like to read. The novel Anak Anak Cahaya has educational values that are obtained based on the experiences of the characters. The values of progressive education in the novel Anak-Anak Cahaya are mutual help, have faith in Allah, mutual cooperation, and never give up.
Radio Mentari FM Solo's Strategy in Maintaining Listener Interest in The Digitalization Era and Learning Implications in High School
Authors: Rozin Yusuf , Markhamah M , Wahyudi Agus Budi
Published: February 2025

Purpose: This research is motivated by how communication media that only rely on sound or audio, namely radio, can maintain listener interest in the era of globalization. The objectives of this research are (1) to be able to describe the digitalization of broadcasting that has been carried out by Radio Mentari FM Solo. (2) to describe the strategy of Radio Mentari FM Solo in maintaining listeners' interest in the digitalization era. (3) to explain the impact of the strategies that have been implemented by Radio Mentari FM. The research method used in this research is descriptive qualitative.
Methodology: The research method used in this research is descriptive qualitative. The data collection technique was carried out using the interview method. Data processing and analysis techniques are carried out by means of qualitative analysis. Results: Based on the research that has been conducted, it is found that Mentari FM Radio has carried out digitalization and broadcast strategies as well as the impact caused by Mentari FM Radio in maintaining listener interest in the digitalization era. Not only maintaining listener interest, Mentari FM also provides services for listeners to provide aspirations and opinions through services, namely telephone and SMS or WhatsApp. Mentari FM also provides services in the form of streaming radio that can be listened to anytime and anywhere that can be accessed via smartphone.
Applications/Originality/Value: In this case this research can be focused on high school level Indonesian language learning for students to train and improve language productive skills, namely speaking skills. The learning outcomes that can be developed by teachers in this case are that students are able to create expressions in accordance with the norms of politeness in communication. This speaking skill will be able to help students to be more confident and courageous to convey their expressions and ideas.
Deviation of Language Politeness Principles in Counter-Comments by Netizens on The Youtube Channel "Tribun Jateng"
Authors: Rohman Ahmad Sani Saefur , Markhamah M
Published: February 2025

Purpose: The purpose of this research is to investigate the use and deviations of linguistic politeness in counter-comments by netizens on videos uploaded by the YouTube channel Tribun Jateng related to the title "Viral Oklin Fia TikToker Uploads Content Licking Ice Cream, Netizens Suspect Blasphemy."
Methodology: The research employed a descriptive research method with a qualitative approach. The data source in this study consists of speech descriptions found in counter-comments on the YouTube video of Tribun Jateng titled "Viral Oklin Fia TikToker Uploads Content Licking Ice Cream, Netizens Suspect Blasphemy."
Results: Data collection in this research was carried out through note-taking techniques. The results of the research indicate netizen opposition to Oklin Fia, who uploaded inappropriate content that does not align with Islamic norms in terms of dressing and the content on his social media account. Thus, communication can also be understood as a process in which the speaker and the interlocutor mutually understand the conveyed messages.
Applications/Originality/Value: From various expert opinions on communication, it can be concluded that communication plays a crucial role in the continuity of human life. Communication is not only conducted through face-to-face interactions but also through indirect means, such as social media.
Character Profile of Pancasila Students in The Film "Sang Prawira" by Onet Adhitia Rizlan and Its Implications in Literature Learning
Authors: Anisa Fitri , Arifin Zainal
Published: February 2025

This research aims to describe the intrinsic elements of the film "Sang Prawira", delineate the character of the Pancasila Student Profile in the film, and explore its implications for literature education. This research utilizes a qualitative descriptive method as it aims to describe phenomena in the form of words or language. The subjects of this study are the characters in the film "Sang Prawira", while the objects are the Pancasila Student Profile character and intrinsic elements. The data source for this research is the film "Sang Prawira," and the data consist of dialogues or quotations from conversations in the film. The data collection technique employs documentation methods with note-taking. The data analysis technique in this study consists of four stages: data collection, data reduction, data presentation, and drawing conclusions. The research findings indicate that there are 15 instances of Pancasila Student Profile data present in the film "Sang Prawira". These 15 data points consist of 5 instances of independent characters, 4 instances of collaborative characters, and 6 instances of global diversity characters. It can be concluded that the global diversity characters are the most dominant in the film. It is expected that these characters can be implemented in literature education in schools. The results of the analysis of independent, collaborative, and global diversity characters can be applied in Indonesian literature education, specifically in teaching poetry writing for Grade IX students in junior high school. It is expected that this implementation will foster a creative and innovative learning environment.
Code Switching and Code Mixing in TikTok Comment Columns and Its Implications for Indonesian Language Learning at High Schools
Authors: Putri Melani Regita , Sulistiyono Yunus
Published: February 2025

The purpose of this research is to analyze the forms of code switching and code mixing in TikTok social media account comments, analyze the forms of slang in TikTok social media account comments, analyze the implications of code switching and code mixing for Indonesian language learning. This type of research is descriptive qualitative research. The data studied in this research consists of TikTok social media user comments that contain code switching, code mixing, and slang. The object of this research is TikTok social media comments. Meanwhile, the subjects of this research are code switching, code mixing, and slang. The data collection techniques used in this research are content analysis and documentation. The steps taken to collect data are as follows; 1). Read carefully the comments of tiktok social media users, 2) identify and record comment quotes, 3) classify the data that has been identified in groups of code switching, mixing, code and slang. In addition to taking notes, researchers also conduct documentation by screenshotting the data that has been found. The data analysis technique in this research uses descriptive qualitative. The results of data analysis are presented in the form of narrative descriptions and explanations regarding code switching, code mixing, and slang under study. In this study researchers used 20 data that had been analyzed, of these 20 data divided into 10 data were the use of code switching and code mixing and 10 data were the use of slang language in the TikTok social media comment column.