bluuebunny/crossref_metadata_2025 huggingface dataset:
Comprehensive Review of Nocturnal Enuresis in Children
Authors:   Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Sarabi Mehrdad , Nikpasand Niloufar ,   Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Mahmoudabadi Elnaz ,   Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Torshizian Ashkan ,   Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Ghodsi Alireza ,   Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Azarfar Anoush ,   Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Published: November 2022

Background: Enuresis is a common problem that affects up to 15% of 5‐year‐old children and may have significant psychological, emotional, and social consequences for both the child and their family. Enuresis is the inability of toilet‐trained children to hold urine during the night. It can be classified as primary and secondary. Secondary enuresis occurs in children who have had a dry duration of more than six months; otherwise, it is called primary enuresis. Objectives: This narrative review aims to summarize the available data on the epidemiology, etiology, pathophysiology, evaluation, and treatment of children with enuresis. Methods: This study was conducted through a literature search with the keywords based on Medical Subject Headings (MESH) and were combined with other keywords, including enuresis, pediatric, incontinence, and treatment using PubMed, Embase, Web of Sciences, Scopus, and Cochrane databases. Results: The initial evaluation of enuresis needs a detailed medical history and a careful physical examination with no need for radiology and invasive procedures. The treatment’s mainstay is non‐pharmacological treatments, such as behavioral intervention followed by pharmacotherapy. The appropriate treatment chosen depends on the children's age, midnight voiding patterns, and family and child preferences. Conclusions: Enuresis is a common disorder that affects both the child and the family in many ways. Enuresis's etiology is complex, and it is still not well understood. The child and family must be included in the treatment process, and potential pathophysiological causes must be taken into account.
The Sudden Death of Fulk I, the King of Jerusalem, or How Power Was Transferred in the Crusader States
Authors:   Institute of World History of the Russian Academy of Sciences, Luchitskaya Svetlana
Published: November 2022

The article examines a tragic episode in the history of the Latin Kingdom of Jerusalem, that is, the sudden death of king Fulk I of Jerusalem. The author tries to answer the question what consequences this event had for the society and state of the crusaders. To this end, she embeds this fact into a more general context of the political history of the Latin Orient. The death of Fulk turns out to have weakened his kingdom and provoked serious political crisis. It triggered a new stage of struggle for power, which eventually escalated into a real civil war, culminating in the accession of Fulk’s son Baudouin III to the throne. The study shows that the crusaders’ state was regarded by its ruling elite not as an institution providing a political framework for society but as a hereditary possession of the rulers which changed hands like any other kind of property. The death of a member of the royal family could disable this system.
The (Un)Expected Death of the Emperor’s Son: the Suicide Stigma in the Medieval Worldview
Authors:   Institute of World History of the Russian Academy of Sciences, Gerstein Anna
Published: November 2022

The author analyses fragments of medieval chronicles describing the circumstances of the death of Henry (VII) of Hohenstaufen (1211-1242) in order to find out how close medieval chroniclers came in their texts to the idea that Henry’s death was actually a suicide. Practically all of 13th and 14th century authors put forward not one but several accounts of how Henry had passed away, the version that involved suicide being one among many others. That was their way of lessening that glaring fact of suicide in the eyes of their audiences. At the same time, contrary to what we would assume given the Christian mentality of medieval society where suicide was considered a gravest sin, there was no blaming of Henry in 13th and 14th century chronicles. Quite the contrary, even those chroniclers who were monks showed compassion for Henry’s fate in their texts and described his funeral as if the deceased had died a natural death. That means that medieval historiographers wanted Henry to be remembered as a good Christian.
“Look, This Is a City!” Regarding the Urban Space with John Amos Comenius, Carl Friedrich Lauckhard and Konstantin Ushinsky
Authors:   Russian Academy of Education, Bezrogov Vitaly ,   Higher School of Economics, Levinson Kirill ,   Tolstoy Tula State Pedagogical University, Romashina Ekaterina ,   Tolstoy Tula State Pedagogical University, Teterin Ivan
Published: November 2022

The article compares Сarl Friedrich Lauckhardt's Illustrated Book for Observation and Instruction (Leipzig 1857–1860) with John Amos Comenius’s Orbis sensualium pictus (Nuremberg 1658) and Konstantin Ushinsky’s Children's World and Reader (St. Petersburg 1861). The main line of comparison regards the ways one phenomenon – the city – was presented in the three books. The authors inquire into the ways Lauckhard, Comenius and Ushinsky viewed and demonstrated to children the city and the urban in general as opposed to the village and the countryside. The comparison comprises practices presented as constituting the urban life; points of view the textbook authors chose to see and to show the city "from within" and "from without", and whether the concepts of the urban changed over time and space like the contents of educational literature did.
“I Regard It as My Duty…” towards Studying the Ethos of Early Twentieth Century Russian Scholars
Authors:   Higher School of Economics, Levinson Kirill
Published: November 2022

The article suggests one possible account of the motives that prompted more than 130 Russian university professors to quit in 1911 as part of the so-called "Casso affair." For this purpose, the author draws on ego-documents, mostly private letters, to analyze the ethos of various social roles which the professor of crystallography Yuri Wulf and his subordinate mineralogist Iosif Sioma took on while corresponding with their colleague, the natural scientist Vladimir Vernadsky, at the turn of the 19th and 20th centuries. The analysis shows that Wulf and Vernadsky, as well as a number of their colleagues, did not separate the ethos of the social role of a scientist from that of a citizen with liberal political convictions, and that a ‘decent person’. This allows us to suggest that their resignation from Moscow University was a move in the political struggle, a demonstration of corporate spirit, and offended decent persons’ response to dishonest behavior on the part of the Minister of Education Léon Casso. However, not all university employees demonstrated such inseparability of social roles: Sioma’s letters to Vernadsky show that he distinguished more clearly the ethos of a representative of the oppressed Polish people, the ethos of a researcher and the ethos of a university employee. This suggests that a range of intermediate variants between the two poles could be identified by a study drawing on a broader range of sources.
Games as Mirrored by the Medieval and Renaissance Visual Culture
Authors:   Institute of World History of the Russian Academy of Sciences, Luchitskaya Svetlana
Published: November 2022

Book review: Games and Visual Culture / Ed. V. Kopp and E. Lapina. Turnhout, 2020
Good Experience in Comparing of the Medieval Cities
Authors:   European University at St. Petersburg, Krom Mikhail
Published: November 2022

Book review: Lukin P.V. Novgorod and Venice: Comparative Historical Essays of Formation of the Republican Order. SPb.: European University at St. Petersburg Press, 2022. 302 p.
“Homines Novi”: Some Notes On This Odysseus Section
Authors:   institute of World History of the Russian Academy of Sciences, Kosheleva Olga
Published: November 2022

The article serves as an introduction to the publication of papers presented at the conference on Homines novi: new social groups in society (November 2021, Moscow, IGH). The conference focused on ‘new people’ emerging in societies of the past, which is closely connected with the problem of ‘the Other’ at large. The contributors analyze the phenomenon of new literati (students, scholars, magisters etc.) emerging as new social strata in some European countries. Other new social groups discussed in the papers include a self-appointed ruler’s retinue, Knights of the Order of the Garter, and the French community in 18th century Russia.
A Machine Vision Solution for Industrial Application of Abrage Inspection and Diameter Measurement On Yarn Bobbins
Authors: GÜLTEKİN Elif , ÇELİK Halil İbrahim , DÜLGER Lale Canan , SÜNBÜL Halil İbrahim
Published: November 2022

The abrage fault inspection and bobbin diameter measurement are very important processes in yarn manufacturing industry. These processes are performed manually, and so they are difficult, low efficient, time-consuming processes. The abrage faults are seen as colour or shade difference on the dyed fabric. This happens when the bobbins including abrage are converted to the fabric form, mistakes in colour differences are seen after dyeing process. An automatic machine vision system was developed for detecting abrage fault, and bobbin diameter from yarn bobbin cross-section view. Image processing software was developed and applied on different sizes of bobbin samples including different types of abrage fault. The success of vision system was statistically evaluated by detecting the bobbin abrage faults with 95.83% accuracy. In addition, the bobbin diameters obtained from the developed image processing algorithm were statistically analysed and the correlation coefficient (R2=0.99) was calculated.
PENGARUH PEMANFAATAN TEKNOLOGI DAN KEMAMPUAN TEKNIK PERSONAL TERHADAP EFEKTIVITAS SISTEM INFORMASI AKUNTANSI
Authors: Ramdah Nafa Nadiyah , Baining Mellya Embun , Khairiyani Khairiyani
Published: November 2022

Tujuan Penelitian: Untuk mengetahui pengaruh pemanfaatan teknologi dan kemampuan teknik personal terhadap efektivitas sistem informasi akuntansi (studi empiris pada PT Djuanda sawit lestari musi rawas).
Desain/Metodologi/Pendekatan Penelitian: Metode yang digunakan adalah kuantitatif dengan analisis linier berganda, dengan uji T dan uji F yang berupa hasil jawaban responden, dan dinyatakan bentuk angka-angka  diukur menggunakan statitsik SPSS 22, jumlah populasi 34 orang karyawan.
Hasil Penelitian: Hasil Penelitian Menunjukkan pengujian secara parsial dan simultan menunjukkan bahwa pemanfaatan teknologi dan kemampuan teknik personal berpengaruh positif dan signifikasi terhadap efektivitas sistem informasi akuntansi.
Implikasi Hasil Penelitian : Hasil penelitian ini memberi gambaran bahwa pemanfaatan teknologi bisa dikuasai dan  digunakan oleh karyawan dengan sebaik-baiknya,agar penggunaan sistem informasi akuntansi berjalan dengan baik.
PENGARUH KONFLIK PERAN GANDA, STRESSOR PEKERJAAN DAN LINGKUNGAN KERJA TERHADAP KEPUASAN KERJA POLISI SATUAN RESERSE DAN KRIMINAL POLRES MERANGIN
Authors: Octodi Krisna Putra , Almasdi Almasdi
Published: November 2022

Purpose: This study aims to examine the effect of (1) dual role conflict, Job stressors on police and The work environment on the job satisfaction of the police of the Merangin Police and Criminal Investigation Unit.

Design/methodology/approach: The population in this study were all 32 police officers from the Merangin Police and Criminal Investigation Unit. And the technique of determining the number of samples taken as respondents with this sampling technique using the total sampling technique (whole sample). The reason for taking total sampling is because according to the total population is less than 100, the entire population is used as a research sample .

Findings: The results of this study indicate that (1) dual role conflict has a negative effect on police job satisfaction at the Bukittinggi Police. (2) Job stressors have a negative effect on job satisfaction of the police of the Merangin Police and Criminal Investigation Unit. (3) The work environment has a positive influence on the job satisfaction of the Merangin Police Criminal and Investigation Unit. (4) Multiple role conflicts, stressors and the work environment together have a significant effect on police job satisfaction at the Merangin Police and Criminal Investigation Units.

Research implications: The results of this study are expected that by having high job satisfaction, the police can provide maximum service to the community, especially in the Merangin Police Criminal and Investigation Unit.
ANALISIS KETIMPANGAN PEMBANGUNAN DI INDONESIA TAHUN 2010-2020
Authors: Zasriati Masrida
Published: November 2022

This study aims to determine how big the level of inequality in Indonesia is and to find out how Klassen's typology in Indonesia is. The data used is secondary data obtained from the official website of the Central Statistics Agency (BPS), then analyzed using the Theil Index and Typology Klassen formulas, with the following research results: 1. Development inequality by province in Indonesia is low or evenly distributed with the Theil index value ranging from 0.01-0.05 or with an average of 0.03 approaching 0. 2. Typology of Klassen Indonesia, which is included in the fast-growing and fast-growing regions (Quadrant I), namely DKI Jakarta Province, and the Archipelago Riau, for the provinces of Riau, East Kalimantan, North Kalimantan, West Papua, and Papua, are included in the developed but depressed regions (Quadrant II), while the provinces of North Sumatra, West Sumatra, Jambi, Bengkulu, West Java, East Java, Banten, Bali , Central Kalimantan, North Sulawesi, Central Sulawesi, South Sulawesi, Southeast Sulawesi, Gorontalo, West Sulawesi, Maluku, and North Maluku, are included in the fast developing areas (Quadrant III), and the Provinces of Aceh, South Sumatra, Lampung, Kep. Bangka, Central Java, DI Yogyakarta, East Nusa Tenggara, West Nusa Tenggara, West Kalimantan, and South Kalimantan, are included in the relatively underdeveloped areas (Quadrant IV).
Iterative species distribution modeling results in the discovery of novel populations of a rare cold desert perennial
Authors: Borokini Israel , Nussear Kenneth , Petitpierre Blaise , Dilts Thomas , Weisberg Peter
Published: November 2022

Niche modeling for rare and range-restricted species can generate inaccurate predictions leading to an overestimation of a species geographic distribution. We used an iterative ensemble modeling approach and model-stratified field surveys to improve niche model formulation and better understand the ecological drivers of Ivesia webberi distribution. I. webberi is a U.S. federally threatened herbaceous species, narrowly distributed in the Western Great Basin Desert. Niche models for I. webberi were fitted using 10 replicates each of six modeling algorithms, while geographical projections of habitat suitability were generated using weighted ensembles of models with optimal performance. The resulting model projections were used to guide field surveys for five years, generating additional spatial data, which were added to the existing dataset for subsequent modeling. Model performance across iterations was investigated, while niche differences in the spatial dataset were explored. Model-guided field surveys resulted in the discovery of several new locations of I. webberi and an expansion of the species’ known range by 63 km. Model performance was higher in the earlier but overfitted niche models; overfitting was corrected in the final models, while predicted habitat suitability was reduced by 50%. Findings show that I. webberi niche is associated with biotic, topographic and bioclimatic variables. Further, a partial overlap was observed between environmental conditions of the initial and new locations (Schoener’s D=0.47), which can be decomposed into 93% of niche stability. This indicates that the majority of the newly discovered locations are within the environmental niche of the initial data.
Sennacherib's Sieges and Deportations Reliefs: How to Increase Emotions
Authors: Battini Laura
Published: November 2022

In this article, I examine the bas-reliefs of Sennacherib dealing with war, deportation, and siege. With a focus on the location of these reliefs, as well as on the subject matter, I attempt to reconstruct the emotional responses which these reliefs would have evoked. Most notably through an examination of their locations in regard to light sources and the gestures of subjects depicted on the reliefs, I argue that the reliefs to not just serve as a show of strength. Rather, they also serve as a form of magical protection for the Assyrian Empire, with Sennacherib depicting his complete control.
“Can I use the toilet?”: Watching Steven Moffat’s Doctor Who (2010-2017) as Posthuman Television
Authors: Hay Jonathan
Published: November 2022

Interpreting the modern television series Doctor Who as an extended metaphor of everyday posthuman life, this article explicates the postphenomenological qualities of the six series released during Steven Moffat’s tenure as showrunner. By explicating precisely how the show’s televisual format amplifies and intersects with its overtly technology-centred narrative content, I develop a posthumanistic conception of Doctor Who’s intra-active rhetorical strategies. This era of the show illustrates the vital role played by the cultural imaginaries of our contemporary lifeworlds upon the realisation of the posthuman future, by vicariously implicating viewers in its mundane discourse. Additionally, its narrative penchant for frequent timeline resets is symptomatic of the intra-active engagements formed between viewers and the technological apparatus of the series itself. By closely analysing a representative sample of episodes, I demonstrate that by watching Doctor Who, viewers are interpellated to recognise their agential capacity to inform our species’ posthuman potential.
EFEKTIVITAS PENGGUNAAN LKPD MATEMATIKA BERBASIS REALISTIC MATHEMATICS EDUCATION TERHADAP HASIL BELAJAR PADA MATERI ARITMATIKA SOSIAL
Authors: Safitri Aulia , Yensy Nurul Astuty , Siagian Teddy Alfra
Published: November 2022

Tujuan dari penelitian ini adalah menghasilkan LKPD berbasis Realistic Mathematic Education pada materi aritmatika sosial di SMP Negeri 11 Kota Bengkulu yang memenuhi kriteria valid, praktis, dan efektif. Penelitian ini adalah penelitian pengembangan dan menerapkan 4 tahapan dari model 4D, yaitu pendefinisian, perancangan, pengembangan dan penyebaran. Instrumen penelitian terdiri dari lembar validitas, lembar kepraktisan, dan tes hasil belajar. Hasil penelitian menunjukkan bahwa pengembangan LKPD berbasis RME memenuhi kriteria efektif dilihat dari ketuntasan belajar peserta didik secara klasikal memperoleh 82% peserta didik yang tuntas serta hasil perhitungan  N gain tes hasil belajar dengan rata-rata N gain  0,78 berada pada kategori “tinggi” .
Rancang Bangun Desain Mesin Pencacah Pakan Sapi Berbasis Software Autodesk Inventor
Authors: Zainur Rahman Rifki , Nuryanto Fani , Cornelia Tjiptady Bella , Dwi Putra Agus
Published: November 2022

Pakan sapi perah pada umumnya seperti jagung, padi, dan rumput gajah. Proses pemotongan yang menggunakan cara tradisional atau dilakukan dengan cara manual memerlukan waktu dan tenaga yang lama. Pada dasarnya desain mesin pemotong harus memudahkan petani untuk meningkatkan produktivitas dalam hal peternakan. Penelitian ini dilakukan dengan metode Research and development. Sumber data yang digunakan dalam perancangan desain mesin pencacah menggunakan sumber data primer atau sumber data yang diperoleh dengan wawancara terhadap peternak sapi. Hasil analisis penelitian ditemukan bahwa rangka mesin mengalami dicplacement sebesar 0,008844-0,00312 dan safety factor sebesar 15 sf. Sedangkan nilai stress sebesar -0,03 Mpa sampai 0,003 Mpa dan strain sebesar 9,88x10-7 sampai 1,35x10-6. Berdasarkan analisis data yang dilakukan dapat disimpulkan bahwa desain yang dirancang memiliki efektifitas yang baik untuk digunakan.
Preliminary Study on Natural Killer Cell Activity for Interferon-Gamma Production after Gamma Knife Radiosurgery for Brain Tumors
Authors: Park Kawngwoo , Jeong Sang Soon , Kim Jung Hoon , Chung Hyun-Tai , Lee Eun Jung , Moon Hyo Eun , Park Kwang Hyon , Kim Jin Wook , Park Hye Ran , Lee Jae Meen , Lee Hye Ja , Kim Hye Rim , Cho Yong Hwan , Paek Sun Ha
Published: November 2022

Objective : High-dose radiation is well known to induce and modulate the immune system. This study was performed to evaluate the correlation between clinical outcomes and changes in natural killer cell activity (NKA) after Gamma Knife Radiosurgery (GKS) in patients with brain cancer.Methods : We performed an open-label, prospective, cross-sectional study of 38 patients who were treated with GKS for brain tumors, including metastatic and benign brain tumors. All of the patients underwent GKS, and blood samples were collected before and after GKS. NKA was measured using an enzyme-linked immunosorbent assay kit, to measure interferon-gamma (IFNγ) secreted by ex vivo-stimulated NK cells from whole blood. We explored the correlations between NK cell-produced IFNγ (NKA-IFNγ) levels and clinical parameters of patients who were treated with GKS for brain tumors.Results : NKA-IFNγ levels were decreased in metastatic brain tumor patients compared to those with benign brain tumors (p<0.0001). All the patients who used steroid treatment to reduce brain swelling after GKS had an NKA-IFNγ level of zero except one patient. High NKA-IFNγ levels were not associated with a rapid decrease in brain metastasis and did not increase after GKS.Conclusion : The activity of NK cells in metastatic brain tumors decreased more than that in benign brain tumors after GKS.
SARS-COV-2: the COVID-19 Virus Overcomes the Immune Response in the ‘at-risk’ group and thereby Infects the Patient yet it is the Autonomic Response which is Most Significant and Determines the Extent and Severity of Infection
Authors: Ewing Graham Wilfred
Published: November 2022

In this article the author illustrates that, at this time (ref COVID-19 Delta and Omicron variants), it is the level of the patient’s autonomic response i.e. the state of their autonomic nervous system, which dictates whether the patient’s health will require hospitalisation and could conceivably cause their demise. The author discusses the difference between the autonomic and immune response(s) and illustrates that what is considered to be the immune response may actually be provided by the autonomic nervous system and why a screening technology which can determine the extent of autonomic dysfunction and/or pathological onset can be so important to determine the patient’s redisposition to infection. Consider also that SARS-COV-2 is a pH sensitive virus. This is significant because it conceivably offers a plausible explanation re why vaccinated populations can be infected with SARS-COV-2, the value of optimising the innate immune response through exercise and hence the need for doctors to emphasise to their patients the need to take steps to be physically active in order to boost their immune response irrespective of whether they have been vaccinated or not, the need for the prevailing statistics to reflect the susceptibility to severe COVID infection of those in the ‘at-risk’ group vs the normally healthy rather than considering the overall population, and the need to recognise the effect of the seasons upon the transmissibility and severity of infection.
Eyelid Notch Procedure for Severe Myogenic Ptosis: A Case Report
Authors: Schwember Jorge , Madrid Luisa , Valdivia Hugo , Hammer Gabriel
Published: November 2022

A case of paralytic eyelid ptosis without frontalis muscle action is reported, due to two prior unsuccessful remedial procedures, an innovative technique is performed.
Anxiety Disorder Caused by Learning Difficulties in Mathematics
Authors: Isabel García-Planas M , Victoria García-Camba M
Published: November 2022

One of the brain disorders causing great damage to those who suffer from it is dyscalculia. Dyscalculia often causes math anxiety. This circumstance is characterized by feelings of tension and fear that interfere with performance in tasks related to Mathematics. Mathematics anxiety is not always caused by a learning difficulty but in cases where this difficulty exists, if it is not diagnosed and treated properly, it is not possible to eliminate the anxiety. By using the BAEP technique, it is possible to determine the existence of a certain type of learning disorder, which allows attention to be focused on remedying the specific cause that produces the anxiety. Due to the existence of multiple factors that cause anxiety, the neuronal system that is activated is a network of interconnected networks whose controllability we need to study. In this work, we also study the controllability of multiagent neural networks by simulating possible brain networks.
Protein substitutions as new-generation pharmanutrition approach to managing phenylketonuria
Authors: Keskin Fatma Nur , Şahin Teslime Özge , Capasso Raffaele , Ağagündüz Duygu
Published: November 2022

Phenylketonuria (PKU), an autosomal recessive inherited metabolic disorder, is caused by a mutation in the phenylalanine hydroxylase (PAH) gene on the 12th chromosome. Defective PAH activity ultimately leads to increased phenylalanine (Phe) blood concentrations (hyperphenylalaninemia) that harm the brain. The primary purpose of PKU treatment is to maintain the blood Phe level to prevent certain undesired effects. Hence, lifelong medical nutrition therapy is recommended for these patients. The usefulness of natural protein sources may be limited, as they are based on individual Phe tolerance, and a patient’s daily protein requirements are supported by Phe-free amino acid mixtures. A few PKU treatment centers recently started using supplemental casein glycomacropeptide, pegvaliase, or large neutral amino acids, and some patients are treated by responding to tetrahydrobiopterin, which works as a pharmaceutical chaperone (prescribed as sapropterin dihydrochloride). This review discusses the efficacy and safety considerations of basic medical nutrition approaches and newgeneration protein substitutes that are used to treat PKU.
Nutritional Status Classification of Toddlers Using K-Nearest Neighbor Algorithm
Authors: Pratiwi Nur Amanda , Atika Prima Dina , Herlawati Herlawati
Published: November 2022

Nutrition is important for the balance of the human body. Knowing the nutritional status is very important to realize the good and the quality human resources. Posyandu Parkit is one of the many Integrated Healthcare Center (posyandu) in Indonesia that provides health services for the community, one of which is monitoring and nutritional development of toddlers. However, the Posyandu Parkit in determining the nutritional status of toddlers is done manually; this method uses measurement parameters based on body weight (BB/U) which are less specific in showing the nutritional status of the toddler by matching manually with a reference standard table available in a healthy card (KMS). The purpose of this research is to produce a website that can determine the nutritional status of toddlers quickly and accurately. The system is designed using the K-Nearest Neighbor method which is a classification method. The K-Nearest Neighbor process is carried out by calculating the distance between the test data and the training data using the Euclidean distance formula, before sorting from the closest distance to the k-th order, then nutritional status is determined. The results of this study are a website that can determine the nutritional status of toddlers by applying the K-Nearest Neighbor algorithm with BB/U, TB/U, and BB/TB accuracies were 93.75%, 87.5%, and 93.75 %, respectively.
Export Management Information System: Evidence from Willbes Global Purwadadi Inc.
Authors: Nuranjani Egin , Purwanti Santi , Hairiyanov Mohamad , Jaja Jaja
Published: November 2022

The case study in this research is the export goods data report at Willbess Global Inc. The purpose of this research is to design an information system for managing data on export goods based on a website at Willbess Global Inc.. This can help the process of inputting export goods data. Willbess Global Inc. always strives to improve its business process services, especially in the field of exporting goods with more systematic data processing. The research method used is the Rational Unified Process (RUP) which is a software engineering method developed by collecting various best practices in the software development industry. RUP uses an object oriented concept, with activities that focus on model development using the Unified Model Language (UML). This research has produced information system functions contained in each process of functional requirements such as managing, deleting, and changing information data on export goods data, data on types of transportation equipment used and data for export goods travel documents.
Editor’s Pick: The Role of Toll-Like Receptors and Antimicrobial Peptides in the Pathogenesis of Acne Vulgaris
Authors: Özlü Emin , Serap Karadağ Ayşe
Published: November 2022

Acne vulgaris (AV) is a chronic inflammatory disease of the pilosebaceous unit. AV has a multifactorial pathogenesis with specific roles played by the sebaceous glands, abnormal follicular hyperkeratinisation, inflammation, Propionibacterium acnes, hormonal factors, immune mediators, and genetic and environmental factors. Significant improvements have been made to elucidate acne pathogenesis, through developments in molecular biology, immunology, and genetic techniques. Toll-like receptors and antimicrobial peptides play significant roles in the host defense system against different pathogenic micro-organisms on the skin and these molecules induce several immunological responses. It is well known that toll-like receptors and antimicrobial peptides play important roles in AV pathogenesis and further understanding of these will contribute to improvements in treatment.
Skin Manifestations Associated with Brucellosis
Authors: Korkmaz Pınar , Doyuk Kartal Elif
Published: November 2022

Brucellosis is a zoonotic infectious disease of worldwide distribution and is still endemic in some developing countries. Brucellosis is a systemic disease in which any organ or system of the body can be involved. The most commonly affected systems are the locomotor, gastrointestinal, genitourinary, haematological, cardiovascular, respiratory, and central nervous systems. Cutaneous manifestations are rare in brucellosis and the lesions are not specific to the disease. Skin involvement is reported to range between 0.4% and 17.0% of the patients with brucellosis. The cutaneous manifestations in brucellosis are seen because of the direct inoculation of bacteria into the skin, hypersensitivity phenomena, deposition of immune complexes in the skin, and invasion of the skin via a haematogenous route of spread of the micro-organism. Papulonodular and maculopapular eruptions, and erythema nodosum-like lesions are the most frequently encountered cutaneous lesions in brucellosis. Brucellosis should be kept in mind by clinicians in the diagnosis of patients with complaints of fever and eruptions, especially in endemic regions.
Special Poster Feature: Certolizumab Pegol: A Future Treatment Option for Patients Suffering from Psoriasis
Authors: Khetrapal Afsaneh
Published: November 2022

Psoriasis is a chronic inflammatory disease that is associated with a reduction in quality of life (QoL) and professional work productivity.1-3 Clinical data presented at the 26th European Academy of Dermatology and Venereology (EADV) congress regarding certolizumab pegol (CZP), an Fc-free pegylated anti-tumour necrosis factor (TNF) antibody, demonstrated a clinically meaningful and sustained psoriasis treatment effect associated with maintained improvements in QoL and work productivity.4-7
Efficacy, Sustainability, and Patient-Reported Outcomes of Guselkumab to Treat Plaque Psoriasis in the Post-Approval Setting
Authors: Barker Michael
Published: November 2022

Plaque psoriasis is an autoimmune condition characterised by the development of red, dry, scaly skin lesions that cause irritation and pain for patients. It is a disabling and disfiguring condition and, alongside the physical effects, is associated with psychological comorbidities, including anxiety and depression.1 Combined effects of the condition are known to affect productivity at work, with increased rates of absenteeism.

Novel targeted therapies have the potential to transform treatment in this field. Adalimumab is a monoclonal antibody that inhibits TNF and has been approved in Europe since 2007 for the treatment of patients with moderate-to-severe chronic plaque psoriasis who are eligible for systemic therapy or phototherapy. Guselkumab is a novel IL-23-blocking monoclonal antibody that has been approved for use in the same indication as adalimumab in Europe since 2017. Personalised treatment is becoming more common and the delivery of therapeutics is a changing landscape, with a shift towards patients administering their own medication through novel devices.

This article reviews four posters displayed at the European Academy of Dermatology and Venereology (EADV) Congress 2018 that present results demonstrating the efficacy of guselkumab compared to adalimumab for the treatment of psoriasis, as measured by a range of outcomes, a favourable drug delivery system, and a higher drug survival rate overall.
Recovery of Palladium Metal with High Purity by Selective Reduction from Inorganic Acid Leaching Solutions of Cemented Zinc
Authors: Song Si Jeong , Nguyen Viet Nhan Hoa , Lee Man Seung
Published: November 2022

A small amount of Pd(II) present in spent electroplating solutions is concentrated by cementation. In this work, a process was developed to recover pure palladium metal by selective reduction from the hydrochloric and the sulfuric acid leaching solutions of cemented zinc. For this purpose, hydrazine and ascorbic acid were employed as reducing agents and the effect of several variables such as the acidity of the leaching solutions, molar ratio of reducing agents to Pd(II), reaction time and temperature was investigated. Since neither of the reducing agents can reduce Pd(II) from strong acidic solutions, it was necessary to decrease the acidity of the leaching solutions by dilution with distilled water. Our results indicated that it was possible to recover Pd metal with high purity by selective reduction after diluting the hydrochloric and sulfuric acid leaching solutions of cemented zinc with distilled water. When the molar ratios of the reducing agents to Pd(II) were the same, the reduction percentage of Pd(II) from the sulfuric acid solution was higher than that from the hydrochloric acid solution, due to the much higher complex formation constant of PdCl42- than Pd(SO4)22-. The reduction of Pd(II) by hydrazine occurred within 15 mins at room temperature, while a higher temperature (60 oC) and longer reaction time (1h) were necessary to reduce Pd(II) with ascorbic acid. The reduction of Pd(II) from sulfuric acid solution was more efficient than from hydrochloric acid solution. It was possible to recover Pd metal with high purity from the leaching solution of cemented zinc using the reduction method.
Lithiation/De-lithiation through Conversion and Alloying Reactions in MAPbBr3 Single Crystal Flake Li-ion Battery Anodes
Authors: Kang In-Seok , Park Byoung-Nam
Published: November 2022

In this study, single-crystalline methylammonium lead tribromide (MAPbBr3, CH3NH3PbBr3) flakes with a higher theoretical specific capacity than methylammonium lead iodide (MAPbI3, CH3NH3PbI3), the prototype of organic/inorganic hybrid perovskite, were synthesized by the inverse temperature crystallization method. The combination of the additive-free electrophoretic deposition (EPD) system and the single crystal fabrication method provided a fundamental understanding of the electrochemical properties associated with the lithium-ion storage mechanism in which the formation of the lithiated-phase (Lix:CH3NH3PbBr3) and the conversion reaction causes significant irreversible capacity, reducing battery cycle stability. The conversion reaction in MAPbBr3 was observed to be the main factor for high irreversible capacity, while the capacity due to the alloying reaction was more significant. The occurrence of the capacity due to the conversion reaction in the slurry system demonstrates that the additives worked as a buffer to relieve the stress associated with the formation of the lithiated phase, which was not observed in the MAPbBr3 EPD film. As part of an investigation of the active material/electrolyte in terms of cycling stability, the problem of structural instability was addressed by replacing the lithium salt and organic solvent that are components of the electrolyte. Our findings shed light on the intrinsic electrochemical properties of MAPbBr3 during lithiation/delithiation in the charging/discharging process, eliminating the complex effect caused by the MAPbBr3/additive mixture. Structural stability at the MAPbBr3/electrolyte interface was probed by varying the solvent and lithium salt.
Effects of V Alloying on Thermoelectric Properties of NbFeSb Half-Heusler Materials Codoped with Ti, Zr, and Sn
Authors: Joo Sung-Jae , Jang JeongIn , Son Ji-Hee , Kim Bong-Seo , Min Bok-Ki
Published: November 2022

NbFeSb-based alloys are promising p-type half-Heusler materials with excellent thermoelectric performance, thermal stability, and naturally abundant constituent elements. Alloying and doping are powerful techniques for enhancing the thermoelectric properties of half-Heusler materials. This study experimentally investigated the effects of V alloying in NbFeSb codoped with Ti, Zr, and Sn. As the V content increases, the electrical conductivity of Nb0.8−xVxTi0.15Zr0.05FeSb0.98Sn0.02 (x = 0, 0.05, 0.1, 0.2, and 0.3) decreases monotonically because of a simultaneous reduction in carrier concentration and mobility, reducing the power factor up to −39% from 4.13 (x = 0) to 2.52 mW m−1K−2 (x = 0.3) at 298 K. Moreover, the lattice thermal conductivity decreases with increasing x by as much as −40% at the maximum V content of x = 0.3, demonstrating that V addition considerably enhances phonon scattering even in the presence of substitutional dopants Ti, Zr, and Sn. The differences in the mass and size of V and Nb atoms cause a substantial decrease in lattice thermal conductivity. According to our study, the addition of a small V content to Hf-free NbFeSbbased alloys can improve their thermoelectric properties, and a maximum dimensionless figure of merit zT of 0.89 was obtained in Nb0.75V0.05Ti0.15Zr0.05Sn0.98Sb0.02 at 973 K.
Threat of landslides hazard at the core zone of Cultural Conservation Strategic Area of Gunung Padang megalithic site, in Cianjur District
Authors: Dewi Indarti Komala , Fauzi Ruslan , Syahbandar M. Yogie
Published: November 2022

The megalithic site of Gunung Padang is an area prone to landslides. Based on the Regulation of Cianjur District No. 17 of 2012, this site area is designated as a Cultural Conservation Strategic Area. This study aims to analyze the potential for landslide hazards in the Gunung Padang Megalithic Site area. The research method is quantitative. Primary data was collected through observation and interview experts; secondary data was collected through literature studies and agency surveys. The analytical method used is quantitative through analysis of Geographic Information Systems (GIS), with overlay and weighting techniques. The results showed three landslide susceptibility classifications: very high, medium, and very low. A very high level of landslide hazard is found in the area around the site, which is currently exposed, amounting to 9.03% of the core zone of the Cultural Conservation Strategic Area.Situs megalitikum Gunung Padang merupakan kawasan rawan longsor. Berdasarkan Peraturan Bupati Cianjur No. 17 Tahun 2012, kawasan situs ini ditetapkan sebagai Kawasan Strategis Cagar Budaya. Penelitian ini bertujuan untuk menganalisis potensi bahaya longsor di kawasan Situs Megalitikum Gunung Padang. Metode penelitian adalah kuantitatif. Data primer dikumpulkan melalui observasi dan wawancara ahli, data sekunder dikumpulkan melalui studi literatur dan survei keagenan. Metode analisis yang digunakan adalah kuantitatif melalui analisis Sistem Informasi Geografis (SIG), dengan teknik overlay dan pembobotan. Hasil penelitian menunjukkan tiga klasifikasi kerawanan longsor yaitu sangat tinggi, sedang dan sangat sangat rendah. Tingkat kerawanan longsor yang sangat tinggi terdapat di wilayah sekitar tapak yang saat ini terpapar, yaitu sebesar 9,03% dari zona inti kawasan strategis cagar budaya.
PENDAMPINGAN MASYARAKAT DALAM PENYUSUNAN PROGRAM PEMBERDAYAAN MASYARAKAT BERBASIS PARTISPATIF DI SEKITAR WILAYAH PERTAMBANGAN DESA MATABURA KECAMATAN AMONGGEDO KABUPATEN KONAWE
Authors: Saleh Fitra , Karim Jufri , Anshari Erwin , Wahab Wahab , Zamili Marwan
Published: November 2022

Matabura Village is one of the villages located in Amonggedo District, Konawe Regency, which is located around the nickel mining area. One of the obligations of mining companies is to develop a Community Empowerment Program (CEP) based on the needs of the community around the mine. The purpose of this activity is to provide participatory-based community assistance whose final product is an inventory of community needs which will later be given to mining companies around Matabura Village to be included in the CEP document. The method used is through Focus Group Discussion (FGD) activities and interviews with a sample of 50 respondents. The results of this activity showed that there was a change in the area of the village boundary from 551 Ha to 399.40 Ha and the number of hamlets from 2 to 3 hamlets and the results of interviews and Focus Group Discussions (FGD) recommended programs to be proposed, namely: Scholarship Program, Repair of Places of Worship, Normalization rivers, Utilization of Human Resources, Sports Facilities, Changing Land Profits, Liming or dolomite on plantation land.
DIAGONALIZATION OF THE BICOMPLEX MATRIX
Authors: KUMAR JOGENDRA
Published: November 2022

In this paper, we have studied and investigated the properties of bicomplex matrices. On invertible and non-invertible bicomplex matrices, we have obtained certain results. The bicomplex matrix’s eigenvalues, eigenvectors and spectrum are also introduced. For bicomplex matrices, the Cayley-Hamilton theorem has been investigated. Furthermore, we discussed the Diagonalizable Bicomplex matrix along with certain results.
EKSISTENSI PEREMPUAN DALAM NOVEL CATATAN JUANG KARYA FIERSA BESARI: KAJIAN FEMINIS-EKSISTENSIALIS
Authors: Iswandi  , Muhammad Adek
Published: November 2022

Even though they are in the modern era, women in various parts of the world are still constrained by various shackles and it is difficult to show their existence. Literary works then become a platform for women to liberate themselves and emphasize their existence even though only symbolically. This study aims to describe the strategies, causes, and impacts of the existence of women in the novel Catatan Juang by Fiersa Besari based on the feminist existentialist study of Simone de Beauvoir. This research is a qualitative research with a library-based study. The analysis was carried out using the content analysis method. The results of this study can be conveyed as follows; (1) there are four strategies for the existence of women in the form of strategies, intellectual women, working women, social transformation women, and independent women, (2) the causes of the emergence of women's existence strategies, among others; social concerns, economic status, and thinking towards change.
The efficacy of vancomycin-loaded biphasic calcium phosphate bone substitute in the promotion of new bone growth and the prevention of postoperative infection
Authors: Wang Shi-Yong , Yao Ru-Bin , Yang Kai-Shun , Liang Huang-Chien , Su Chen-Ying , Fang Hsu-Wei , Lim Sher-Wei
Published: November 2022

Background: Due to the increasing need for suitable alternatives to bone grafts, artificial bones made of biphasic calcium phosphate (BCP) are currently being extensively researched. These porous bone substitutes have also demonstrated considerable incorporation with the host bone, and new bone is able to grow within the porous structure. They therefore offer a potential therapeutic approach for bone defects.

Methods: Vancomycin-loaded Bicera™, a BCP bone substitute, was investigated in order to prevent implant-associated osteomyelitis and postoperative infection after orthopedic surgery. The loading capacity of Bicera™ was measured to understand its potential antibiotic adsorption volume. An antibiotic susceptibility test was also carried out to analyze the effect of Bicera™ loaded with different concentrations of vancomycin on the growth inhibition of methicillin-resistant Staphylococcus aureus (MRSA). Vancomycin-loaded Bicera™ was implanted into rabbits with bone defects, and general gross, radiographic, and histological evaluation was undertaken at 4, 12, and 24 weeks after implantation.

Results: The maximum loading capacity of vancomycin-loaded Bicera™ was 0.9 ml of liquid regardless of the vancomycin concentration. Antibiotic susceptibility tests showed that vancomycin-loaded Bicera™ inhibited the growth of MRSA for 6 weeks. In addition, animal studies revealed that new bone grew into the vancomycin-loaded Bicera™. The percentage of new bone formation from 4 to 24 weeks after implantation increased from 17% to 36%.

Conclusion: Vancomycin-loaded Bicera™ could effectively inhibit the growth of MRSA in vitro. It was found to incorporate into the host bone well, and new bone was able to grow within the bone substitute. The results of this study indicate that vancomycin-loaded Bicera™ is a potential bone substitute that can prevent implant-associated osteomyelitis and postoperative infection.