bluuebunny/crossref_metadata_2025 huggingface dataset:
Framework for Analyzing Human Cognition in Operationally-Relevant Human Swarm Interaction
Authors: Distefano Joseph P. , Cho Hanvit , Krisshnakumar Prajit , Chowdhury Souma , Esfahani Ehsan
Published: November 2023

For a wide variety of envisioned humanitarian and commercial applications that involve a human user commanding a swarm of robotic systems, developing human-swarm interaction (HSI) principles and interfaces calls for systematic virtual environments to study such HSI implementations. Specifically, such studies are fundamental to achieving HSI that is operationally efficient and can facilitate trust calibration through the collection-use-modeling of cognitive information. However, there is a lack of such virtual environments, especially in the context of studying HSI in different operationally relevant contexts. Building on our previous work in swarm simulation and computer game-based HSI, this paper develops a comprehensive virtual environment to study HSI under varying swarm size, swarm compliance, and swarm-to-human feedback. This paper demonstrates how this simulation environment informs the development of an indoor physical (experimentation) environment to evaluate the human cognitive model. New approaches are presented to simulate physical assets based on physical experiment-based calibration and the effects that this presents on the human users. Key features of the simulation environment include medium fidelity simulation of large teams of small aerial and ground vehicles (based on the Pybullet engine), a graphical user interface to receive human command and provide feedback (from swarm assets) to human in the case of non-compliance with commands, and a lab-streaming layer to synchronize physiological data collection (e.g., related to brain activity and eye gaze) with swarm state and human commands.
Efficient Robust Design Space Visualization and Exploration for Many-Objective Problems – A Vehicular Crashworthiness Example
Authors: Balaji Niharika , Baby Mathew , Sharma Gehendra , Rama Sushil Rashmi , Ramu Palaniappan , Nellippallil Anand Balu
Published: November 2023

The design of vehicular components is often complicated by the presence of many conflicting goals, such as improved energy absorption for safety, mass reduction for increased fuel economy, and so on. The uncertainties associated with the manufacturing processes involved in realizing the components impact vehicular performance. Hence, the design of vehicular components needs to account for many conflicting goals and associated uncertainties to ensure performance. We look at managing the uncertainties involved by exploring the design space and seeking a ranged set of ‘satisficing robust solutions’ that are relatively insensitive to uncertainties while still meeting the requirements of the designers.

In this paper, we present a robust design exploration framework that combines the robust concept exploration framework with a machine learning-based visualization technique called interpretable Self-Organizing Map (iSOM) to support the design exploration and visualization for problems with many (more than three) conflicting goals. In the framework presented, we examine uncertainty associated with the design variables that define the many conflicting goals. A robust goal formulation using the Design Capability Index (DCI) construct is employed in the framework to account for the design variable uncertainties. The use of iSOM for visualization of design spaces allows designers to overcome the limitation of conventional ternary plot-based visualization, where designers are limited to visualizing a maximum of 3 goals at a time. The framework presented supports designers in efficiently visualizing and exploring high-dimensional robust design spaces and identifying satisficing robust solutions, which was not possible previously.
Capturing Parkinson’s Disease Tremor and Vigor With a Single Disease Parameter
Authors: Haman Michael J. , Kelley Christopher R.
Published: November 2023

Parkinson’s disease (PD) is a progressive neurological disorder that significantly affects movement. It is caused by a loss of dopamine-producing cells in the basal ganglia, a group of brain structures that play a key role in motor control. Two of the most pronounced motor symptoms in PD are tremor and reduced movement vigor, known as bradykinesia. This research hypothesizes that a single physiological mechanism can produce both tremor and movement inhibition in PD through its influence on system-level controller parameters. This paper explores this hypothesis with a model that uses a single disease parameter to change the movement planning stage and closed-loop dynamics in a way that produces both motor symptoms. Model simulations evaluate the motion of the arm and the wrist during reaching and rest tasks as the disease parameter increases. The results confirm that a single parameter can produce parkinsonian-like tremor and vigor and also indicate that limb dynamics may play a key role in tremor expression.
Surrogate Modeling of Car Drag Coefficient With Depth and Normal Renderings
Authors: Song Binyang , Yuan Chenyang , Permenter Frank , Arechiga Nikos , Ahmed Faez
Published: November 2023

Generative AI models have made significant progress in automating the creation of 3D shapes, which has the potential to transform car design. In engineering design and optimization, evaluating engineering metrics is crucial. To make generative models performance-aware and enable them to create high-performing designs, surrogate modeling of these metrics is necessary. However, the currently used representations of three-dimensional (3D) shapes either require extensive computational resources to learn or suffer from significant information loss, which impairs their effectiveness in surrogate modeling. To address this issue, we propose a new two-dimensional (2D) representation of 3D shapes. We develop a surrogate drag model based on this representation to verify its effectiveness in predicting 3D car drag. We construct a diverse dataset of 9,070 high-quality 3D car meshes labeled by drag coefficients computed from computational fluid dynamics (CFD) simulations to train our model. Our experiments demonstrate that our model can accurately and efficiently evaluate drag coefficients with an R2 value above 0.84 for various car categories. Moreover, the proposed representation method can be generalized to many other product categories beyond cars. Our model is implemented using deep neural networks, making it compatible with recent AI image generation tools (such as Stable Diffusion) and a significant step towards the automatic generation of drag-optimized car designs. We have made the dataset and code publicly available at https://decode.mit.edu/projects/dragprediction/.
Supplemental Material: Insights into Caribbean tectonics from a detrital zircon U-Pb provenance study of siliciclastic strata in western and central Cuba
Authors: Ascanio-Pellon Patricia , et al.
Published: November 2023

Supplemental File S1: Sample location and structural measurements with full U-Pb raw data of unknowns and standards. Supplemental File S2: Analytical conditions table. Supplemental File S3: Standards Concordia plots. Supplemental File S4: Cuban sample Concordia plots. Supplemental File S5: Zircon grain mounts. Supplemental File S6: Outcrop photographs.
Novel treatments for novel side effects: a case report and review of baricitinib use in the treatment of chronic inflammatory demyelinating polyneuropathy caused by immune checkpoint inhibitor use
Authors: Haider Sana , Chua Wei , Balakrishnar Bavanthi , Della-Fiorentina Stephen , Roberts Tara Laurine , Keat Karuna
Published: November 2023

Immune checkpoint inhibitors (ICIs) have transformed the landscape of solid cancer management. These drugs carry a risk of novel side effects, which have become known as immune-related adverse events (irAEs).

Traditionally, irAEs have been managed empirically with corticosteroids. A subset of these may be steroid refractory and as more evidence emerges about their distinct pathogeneses, a more tailored approach is required. Here, we report the use of a Janus kinase (JAK) inhibitor, baricitinib, in a patient with chronic inflammatory demyelinating polyneuropathy secondary to ICI use. We also review the current literature with regards to the use of these inhibitors in the management of irAEs.

Modulation of the JAK pathway warrants further investigation in the targeted management of irAEs.
A Formal Approach to Model the Expansion of Natural Events: The Case of Infectious Diseases
Authors: Teresa Signes-Pont Maria , Boters-Pitarch Joan , Szymanski Julian , Mora-Mora Higinio
Published: November 2023

A formal approach to modeling the expansion of natural events is presented in this paper. Since the mathematical, statistical or computational methods used are not relevant for development, a modular framework is carried out that guides from the external observation down to the innermost level of the variables that have to appear in the future mathematical-computational formalization. As an example we analyze the expansion of Covid-19. We perform a qualitative estimation of the impact of the causes on the delays of the spread and an analysis of the parameters.
Assessing the impact of hydrodynamics on capillary seal capacity: application of the Manzocchi & Childs model in trap analysis workflows
Authors: Grant Neil T.
Published: November 2023

The evaluation of seal in conventional stratigraphic and structural traps requires the characterization of the capillary top seal to assess the capacity to hold a hydrocarbon column. Typically, this seal analysis addresses the static seal and does not consider the role that hydrodynamics (the flow of water into or out of the reservoir) may play in influencing the seal capacity. Although possessing extremely low permeability, shale seals are not perfect seals and water can seep through them under an imposed hydraulic gradient. Likewise, water can move vertically through trapped hydrocarbon columns even though relative permeabilities are very low. The impact of this flow on the capillary seal capacity can, in theory, be quite profound and should be considered in seal analysis workflows. This paper revisits the Manzocchi & Childs model for hydrodynamic effects on capillary seals and employs it directly in real-world trap analysis. The implementation of this model is described, and a workflow developed to incorporate the impact of hydrodynamics into column height prediction. The technique is applied to several known over-pressured fields from the Norwegian continental shelf to evaluate its applicability. Preliminary results from Monte Carlo modelling are promising and with some agreement between the observed column heights and the predicted hydrodynamic seal-controlled columns, dependant on the parameterization used. Further testing is ongoing, but the methodology should be considered in exploration prospect evaluation. The impact of hydrodynamics on seal capacities should not be discounted.

Thematic collection:
This article is part of the Fault and top seals 2022 collection available at:
https://www.lyellcollection.org/topic/collections/fault-and-top-seals-2022
A Surprising Journey Through a Changing Landscape
Authors: DeNisi Angelo S.
Published: November 2023

My research journey was completely unexpected. I never envisioned becoming a professor, or still working after more than 40 years. I discuss this journey in terms of how events unfolded without much planning, in hopes of encouraging others to accomplish more than they believe they can. Since I have had a long career, I also discuss some ways in which the field of management has changed and how these present challenges to our field in the future. It is my contention that the field benefits most from good scholars doing good work on topics that interest them, and not by scholars learning how to game the system or worrying too much about which journals “count.” I also discuss some differences I experience being associated with both the Society for Industrial and Organizational Psychology (SIOP) and the Academy of Management. I conclude on an optimistic note pointing out various efforts to address some of the challenges I outlined.
Workaholism: Taking Stock and Looking Forward
Authors: Taris Toon W. , de Jonge Jan
Published: November 2023

Drawing on 50 years of research, this article defines workaholism as involving high motivation (e.g., being driven to work due to internal pressures) as well as high effort expenditure (e.g., having persistent thoughts about work when not working and working beyond what can reasonably be expected). Workaholism can be distinguished from concepts such as work engagement, work passion, and Type-A behavior, and valid workaholism measures are available. Regarding its antecedents, demographic and personality factors are weakly related to workaholism. Work-related factors (such as the presence of an overwork culture and high job demands) are more important. Workaholism may have adverse outcomes for a worker's mental and physical health, well-being, and family life. Workaholics do not perform better (but may well perform worse) than others. Although many interventions have been put forward to address workaholism, the effects of these are usually unclear. We conclude with a short agenda for future research.
Gender‐ and Age‐Related Differences of Ocular Biometric Parameters in Patients Undergoing Cataract Surgery in Bosnia and Herzegovina
Authors: Zvorničanin Edita , Vatavuk Zoran , Popović Maja , Zvorničanin Jasmin
Published: November 2023

Purpose. The aim of the study is to determine the distribution and mutual relationship of ocular biometric parameters, as well as to evaluate gender‐ and age‐related differences in patients undergoing cataract surgery in Bosnia and Herzegovina. Materials and Methods. It was a retrospective cross‐sectional study of consecutive patients who underwent cataract surgery between January 2017 and December 2021 in a tertiary care clinic. All biometric measurements were performed using the optical biometer OA‐2000 (Tomey, Nagoya, Japan). Results. The study evaluated 1278 eyes from 1278 consecutive cataract patients. The average age of all included patients was 69.4 ± 9.98 (range 40–96). A total of 672 eyes (52.58%) were from females. The mean axial length (AL), anterior chamber depth (ACD), lens thickness (LT), and mean keratometry were 23.46 ± 1.18 mm, 3.17 ± 0.40 mm, 4.54 ± 0.48 mm, and 43.42 ± 1.55D, respectively. Corneal astigmatism of ≥1D, >2D and >3D was found in 33.4%, 7.8% and 2.5% patients, respectively. Females were found to have shorter AL (p < 0.0001), shallower ACD (p < 0.0001) and steeper corneas (p < 0.0001). In both genders, AL, ACD and with the rule astigmatism showed a decreasing trend (p = 0.0001), while keratometry, the average cylinder, and against the rule astigmatism showed an increasing trend (p = 0.0001) with increasing age. Furthermore, in both genders, there was an increasing trend in ACD (p = 0.0001), and a decreasing trend in keratometry (p = 0.0001) and LT (p = 0.0001) with increasing AL. Conclusions. This study provides useful reference data on ocular biometry for cataract surgeons in Bosnia and Herzegovina. Female patients tend to have steeper corneas, shorter AL and shallower AC than males, and these differences are independent of age or AL.
Carob (Ceratonia siliqua L.) Seed Constituents: A Comprehensive Review of Composition, Chemical Profile, and Diverse Applications
Authors: Laaraj Salah , Salmaoui Souad , Addi Mohamed , El-rhouttais Chaimae , Tikent Aziz , Elbouzidi Amine , Taibi Mohamed , Hano Christophe , Noutfia Younes , Elfazazi Kaoutar
Published: November 2023

Carob (Ceratonia siliqua L.) is a tree species native to the Mediterranean region and belongs to the Fabaceae family. The tree is well-known for its sweet and nutritious fruits, which have been used for long time as a nutritious food. In addition to the edible fruits, the carob tree also produces seeds that are highly prized for their ability to produce carob gum (locust bean gum). The carob seed consists of three main components: the shell, the endosperm, and the embryo. The shell is the outermost layer of the seed, followed by the endosperm, which is the largest part of the seed and contains high levels of carbohydrates and proteins. The embryo is the smallest part of the seed and is rich on bioactive compounds. Carob seed constituents have attracted considerable attention due to their exceptional nutritional and therapeutic properties in various industries, including food, medicine, pharmaceuticals, cosmetics, and textiles. The high content of bioactive compounds in carob seeds, such as polyphenols, tannins, and flavonoids, is believed to be responsible for their antioxidant and anti-inflammatory properties. The use of carob seed constituents in the food industry is mainly due to their ability to act as thickeners and stabilizers in various foods. They are used as a substitute for other thickening agents such as guar gum and carrageenan, due to their superior properties. In the pharmaceutical industry, carob seeds have been found to have antidiabetic, antihyperlipidemic, and anticancer properties, among others. The cosmetics industry is also interested in the ingredients of carob seed, as they can improve hydration and elasticity of the skin. They are also used as a natural alternative to synthetic thickeners in cosmetic formulations. The textile industry has also recognized the potential of carob seed constituents, as they can be used as a natural dye and as a sizing agent to improve the strength and durability of textiles. In summary, carob seed constituents offer a wide range of applications in various industries, owing to their high content of bioactive compounds, excellent nutritional and therapeutic profile, and ability to act as thickeners, stabilizers, and antioxidants. This review has highlighted the latest findings on the chemical composition, applications, and health benefits of carob seed constituents.
Malignant Transformation of Unknown Duration of an Ovarian Mature Cystic Teratoma Presenting as a Trocar Recurrence in a Young Patient: A Case Report and Literature Review
Authors: Okuda Tomohiro , Uda Yoko , Sakai Shiho , Harada Taishi
Published: November 2023

Although laparoscopic cystectomy is a safe and effective management strategy for ovarian mature cystic teratoma (MCT) in pediatric and adolescent patients, it has been challenged because of its association with a higher risk of intraoperative spillage leading to chemical peritonitis, adhesion formation, and iatrogenic implantation of malignant cells. Here, we report a rare case of a 23-year-old female patient with MCT tissue during laparoscopic ovarian cystectomy that remained in the peritoneum, possibly becoming malignant thereafter. Intraoperatively, the cyst’s contents leaked into the abdominal cavity. The abdominal cavity was thoroughly cleaned before the operation was completed. Pathological examination revealed an MCT without malignant findings. The patient’s postoperative course was uneventful. Although the excised tissue was benign, the patient presented with a mass at the trocar wound (upper suprapubic area) 2 years after initial surgery. Biopsy results indicated squamous cell carcinoma. Moreover, peritoneal and bladder invasions were diagnosed. She subsequently experienced symptoms of cancerous peritonitis. Achieving a complete cure through surgery alone was deemed difficult; however, successful neoadjuvant chemotherapy and tumor reduction surgery kept her alive up until the publication of this case report, 3 years since diagnosis with squamous cell carcinoma. This case indicates that malignant transformation of MCTs can occur at any age.
The Dance Between Tumor Molecular Biology and Antitumor Immune Response
Authors: Margolin Kim A.
Published: November 2023

When the cyclin kinase 4/6 inhibitor abemaciclib was sequenced with PD-1 blockade in mostly immunologically “cold” murine models, enhanced immune-mediated antitumor effects—including increased lifespan, recruitment of CD8 cells to tumor, reduction of regulatory T-cell and immunosuppressive cytokines in tumor, increased tumor antigen presentation, and broadening of the T-cell receptor repertoire—were achieved in both cutaneous and brain metastases.

See related article by Nayyar et al., p. 420
Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis
Authors: Pichavaram Prahalathan , Jablonowski Carolyn M. , Fang Jie , Fleming Andrew M. , Gil Hyea Jin , Boghossian Andrew S. , Rees Matthew G. , Ronan Melissa M. , Roth Jennifer A. , Morton Christopher L. , Zambetti Gerard P. , Davidoff Andrew M. , Yang Jun , Murphy Andrew J.
Published: November 2023

The histone lysine demethylases KDM4A-C are involved in physiologic processes including stem cell identity and self-renewal during development, DNA damage repair, and cell-cycle progression. KDM4A-C are overexpressed and associated with malignant cell behavior in multiple human cancers and are therefore potential therapeutic targets. Given the role of KDM4A-C in development and cancer, we aimed to test the potent, selective KDM4A-C inhibitor QC6352 on oncogenic cells of renal embryonic lineage. The anaplastic Wilms tumor cell line WiT49 and the tumor-forming human embryonic kidney cell line HEK293 demonstrated low nanomolar QC6352 sensitivity. The cytostatic response to QC6352 in WiT49 and HEK293 cells was marked by induction of DNA damage, a DNA repair–associated protein checkpoint response, S-phase cell-cycle arrest, profound reduction of ribosomal protein gene and rRNA transcription, and blockade of newly synthesized proteins. QC6352 caused reduction of KDM4A-C levels by a proteasome-associated mechanism. The cellular phenotype caused by QC6352 treatment of reduced migration, proliferation, tumor spheroid growth, DNA damage, and S-phase cell-cycle arrest was most closely mirrored by knockdown of KDM4A as determined by siRNA knockdown of KDM4A-C. QC6352 sensitivity correlated with high basal levels of ribosomal gene transcription in more than 900 human cancer cell lines. Targeting KDM4A may be of future therapeutic interest in oncogenic cells of embryonic renal lineage or cells with high basal expression of ribosomal protein genes.
Bedside Ultrasound in the Management of Cardiorenal Syndromes: An Updated Review
Authors: Argaiz Eduardo R. , Romero-Gonzalez Gregorio , Rola Philippe , Spiegel Rory , Haycock Korbin H. , Koratala Abhilash
Published: November 2023

Background: Cardiorenal syndromes constitute a spectrum of disorders involving heart and kidney dysfunction modulated by a complex interplay of neurohormonal, inflammatory, and hemodynamic derangements. The management of such patients often poses a diagnostic and therapeutic challenge to physicians owing to gaps in understanding of pathophysiology, paucity of objective bedside diagnostic tools, and individual biases. Summary: In this narrative review, we discuss the role of clinician who performed bedside ultrasound in the management of patients with cardiorenal syndromes. Novel sonographic applications such as venous excess ultrasound score (VExUS) are reviewed in addition to the lung and focused cardiac ultrasound. Further, underrecognized causes of heart failure such as high-flow arteriovenous fistula are discussed. Key Message: Bedside ultrasound allows a comprehensive hemodynamic characterization of cardiorenal syndromes.
FoxP3-Positive Cells and Their Contacts with Mast Cells Are Highly Increased in Basal Cell Carcinoma
Authors: Kaukinen Antti P. , Harvima Rauno J. , Harvima Ilkka T.
Published: November 2023

Introduction: The cells of the immune system are thought to contribute to the development of skin cancers, such as basal cell carcinoma (BCC). One possible mechanism may be the interaction between mast cells and regulatory T cells (Tregs), resulting in immunosuppression. Methods: Fresh-frozen biopsies from the lesional and nonlesional skin of 16 patients with BCC were processed for the enzymehistochemical staining of mast cell tryptase, immunohistochemical staining of FoxP3 (a marker of Tregs) as well as for the double-staining method to label tryptase+ cells and FoxP3+ cells on the same cryosection. The cell numbers and apparent morphological contacts (AMCs) between these cell types were counted. Results: There was a high increase in the number of tryptase+ cells, FoxP3+ cells, and AMCs between them in the lesional compared to corresponding nonlesional skin (p < 0.0001) in all cases. Conclusion: A morphological basis is theoretically present in BCC, suggesting an immune evasive microenvironment.
Association between Fibrinogen-to-Albumin Ratio and Adverse Stroke Outcomes among Patients with Acute Ischemic Stroke
Authors: Wang Xiaoyu , Pan Yuesong , Zhang Runhua , Wang Mengxing , Qin Haiqiang , Meng Xia , Li Zixiao , Li Hao , Wang Yilong , Zhao Xingquan , Wang Yongjun , Liu Gaifen
Published: November 2023

Introduction: Fibrinogen-to-albumin ratio (FAR) is implicated in prothrombotic states and is associated with an increased risk of acute ischemic stroke (AIS). However, studies investigating whether the prothrombotic effect of FAR is associated with long-term adverse outcomes in patients with AIS are lacking. Therefore, we aimed to investigate the association based on the Third China National Stroke Registry (CNSR-III). Methods: Patients with AIS with complete laboratory data for fibrinogen and albumin in the CNSR-III were included in this study. The primary outcomes were poor functional outcomes (modified Rankin scale score 3–6) at 12 months, including disability (modified Rankin scale score 3–5), all-cause death, recurrent stroke, and combined vascular events within 1 year. Univariate and multivariate logistic or Cox regression analyses were used to investigate the association between FAR quartiles and adverse outcomes. Results: A total of 8,984 patients with AIS were enrolled in this study. After 1-year follow-up, 238 patients were lost to follow-up. A total of 1,230 (14.06%) patients had poor functional outcomes; 932 (10.37%) and 981 (10.92%) experienced stroke recurrence and combined vascular events, respectively. The adjusted odds ratios/hazard ratios and 95% confidence intervals of the highest quartile of the FAR (>11.44) were 1.64 (1.35–2.00) for poor functional outcomes, 1.68 (1.34–2.10) for disability, 1.40 (1.02–1.94) for all-cause death, 1.11 (0.92–1.34) for stroke recurrence, and 1.11 (0.92–1.33) for combined vascular event, respectively. Conclusion: High FAR (>11.44) increased the risk of short- and long-term poor functional outcomes, including disability and all-cause death among patients with AIS. The FAR may play an important role in the early stratification of patients with AIS.
Oxidative Stress Accompanies HIF1-Dependent Impairment of Glucose Metabolism in the Hippocampus of Adult Rats That Survived Prenatal Severe Hypoxia
Authors: Vetrovoy Oleg , Stratilov Viktor , Potapova Sofiya , Tyulkova Ekaterina
Published: November 2023

Introduction: Many socially significant diseases are associated with prenatal developmental disorders. Previously, we showed the pathological role of hypoxia-inducible factor-1 (HIF1) in post-hypoxic reoxygenation. This study aimed to investigate the effect of prenatal severe hypoxia (PSH) on HIF1α protein expression as well as on HIF1-dependent activity of the pentose phosphate pathway (PPP) and anaerobic glycolysis in the hippocampus (HPC) of offspring that reached adulthood. Methods: PSH was induced during the critical period of fetal hippocampal formation on gestation days 14–16 in a hypobaric chamber (180 Torr, 5% oxygen, 3 h). Subsequent studies were conducted on both the HPC of adult control and PSH rats under normal conditions, as well as in response to severe hypoxia (SH) or psycho-emotional stress (“learned helplessness” [LH] model). We evaluated HIF1α protein levels using both immunohistochemistry and Western blotting techniques. The amount of glucose-6-phosphate dehydrogenase (G6PD) was also determined by Western blotting. Colorimetric enzymatic assays were employed to analyze enzymatic activity of lactate dehydrogenase (LDH), the concentration of lactate, NADPH, reduced glutathione (GSHred), and malonic dialdehyde (MDA). Results: We showed that PSH caused a stable increase in the content of HIF1α protein in the HPC, which was accompanied by an increase in the efficiency of anaerobic glycolysis. This was confirmed by increased LDH activity and lactate concentration. At the same time, the amounts of G6PD, NADPH, and GSHred decreased in the HPC of PSH rats, whereas the concentration of MDA, an oxidative stress marker, exceeded the control values. In a series of experiments using the LH or SH stress, it was shown that in the HPC of control rats, there was an increase in the amount of HIF1α in response to stress, which was also accompanied by more efficient anaerobic glycolysis and decrease of PPP-dependent NADPH production, similar to the intact PSH rats. In PSH rats, emotional stress resulted in higher HIF1α levels without affecting glycolysis or PPP. Conclusion: Therefore, the increased content and activity of the transcription factor HIF1α in the HPC of adult rats exposed to prenatal hypoxia leads to an imbalance between glycolysis and PPP, which is accompanied by oxidative stress.
CT Hyperdense Lesions after Endovascular Therapy in Acute Ischemic Stroke: Imaging Findings and Clinical Significance
Authors: Yu Wei , Xia Chao , Tao Bo , Xiao Yuan , Gao Ziyang , Zhu Fei , Zhao Qiannan , Lui Su
Published: November 2023

Background: The hyperdense lesion on non-contrast CT (NCCT) is a common postoperative phenomenon in acute ischemic stroke patients who are treated with endovascular therapy (EVT). Both contrast extravasation and hemorrhagic transformation presented hyperdense lesions on NCCT, which are sometimes difficult to distinguish them. Summary of Review: Radiographic findings are important for identifying contrast extravasation and hemorrhagic transformation. We recommended a standardized follow-up protocol involving imaging and clinical evaluation as it will allow neurologists and neuroradiologists to reveal the relationships between these hyperdensities and various clinical outcomes. Key Messages: Dual-energy CT and susceptibility-weighted imaging are capable of distinguishing contrast extravasation and hemorrhagic transformation at an early stage after EVT. However, in institutions without access to such technology, a follow-up protocol based on NCCT is crucial.
NAVIGATING DISRUPTIVE CONSUMER BEHAVIOR AND TECHNOLOGIES: OPPORTUNITIES, NICHES, TRANSFORMATION, AND COLLABORATION
Authors: Nuralam Inggang Perwangsa , Miyazaki Kosuke , Ramadhani Zaki Alif
Published: November 2023

In the contemporary and ever-evolving business environment, the convergence of disruptive consumer behavior and cutting-edge technologies has ushered in a period of remarkable transformation and opportunity. It is imperative for entrepreneurs to comprehend the motivations and actions of these empowered consumers as they navigate through this transformative phase. Disruptive technologies represent innovations that disrupt established markets. Collaborative consumption, emphasizing shared access, efficiency, waste reduction, and community building, has emerged as a compelling trend. This literature review explores the impact of disruptive consumer behavior and technological shifts prompted by observed changes in consumer behavior and technological disruptions. The primary objective of this study is to provide insights and strategies for individuals and businesses to effectively respond to disruptive consumer behavior and technologies. In summary, today's entrepreneurial landscape is characterized by perpetual change and adaptation, with innovation and disruptive forces at its core. Entrepreneurs who embrace innovation, adapt to disruptive consumer behavior, leverage disruptive technologies, and engage with collaborative consumption are not only well-equipped to navigate disruptions but also positioned to pioneer new growth opportunities, drive industry evolution, and shape the future of business.
FINTECH ATTAINING SUSTAINABLE ENTREPRENEURSHIP
Authors: Imamah Nur , Nafisa Layyin
Published: November 2023

Markets are increasingly relying on technology to facilitate transactions. Increasing the number of customers interacting using technology will create long-term success for the business. In addition to changing how people interact with finance in the modern day and allowing businesses to compete, financial technology innovation delivers financial services to previously neglected populations and market sectors. Financial technology (Fintech) has achieved wide acceptance as a means of conducting financial transactions and is crucial to the growth of the financial system and the economy. Fintech, which refers to digital innovation to improve, develop, and automate financial services to promote and support businesses, business owners, and investors in managing their economic activities, is essentially the junction of finance and technology. To transform the financial sector and how businesses run, fintech is essential. Anyone with an internet connection can use fintech services, which experts anticipate will disrupt the dynamics of the whole industry and result in significant changes to the competitive structure and functionality of financial services. Examples include digital credit and lending (such as online lending, peer-to-peer lending, and crowdfunding), digital payment systems (including mobile banking and mobile payments), digital currencies (such as cryptocurrency and blockchain), digital insurance, Fintech global solutions, and digital data analytics. The emergence of fintech has opened up new opportunities for entrepreneurship and has the potential to drive both short-term and long-term business growth.
CORPORATE SOCIAL RESPONSIBILITY ACTIONS BY FAST FASHION INDUSTRY: PRO-ENVIRONMENTAL OR STRATEGIC TAX BEHAVIOR?
Authors: Asmoro Priandhita Sukowidyanti
Published: November 2023

The fast fashion industry, known for its rapid production and affordability, has gained prominence in recent years but also faces growing scrutiny due to its adverse social impacts and significant contribution to waste, pollution, and emissions, exacerbating the triple planetary crisis. The discussion reveals the multifaceted factors influencing CSR engagement, from stakeholder activism to consumer awareness and shareholder pressure. While CSR promises to address societal and environmental issues, challenges related to cost-efficiency and regulatory frameworks hinder its widespread adoption. Lastly, this article explores the complex relationship between CSR actions and strategic tax behavior within the fast fashion industry, focusing on developing countries. It examines four key theoretical perspectives: Shareholder Theory, Stakeholder Theories, Legitimacy-Based Theories, and Political Cost Theory. The research reveals the multifaceted motivations and challenges fast fashion companies face in engaging with CSR and the impact of taxation strategies on their CSR initiatives. Furthermore, it highlights the significance of stakeholder activism, consumer awareness, regulatory environments, and competitive landscapes in shaping CSR practices within this industry. The study underscores the need for a nuanced understanding of CSR and taxation in the fast fashion industry's context, emphasizing the pivotal role of ethical considerations, societal norms, and political dynamics
Fostering Sustainable Entrepreneurship In Emerging Market: An Interdisciplinary Perspective
Authors: Nuralam Inggang Perwangsa , Nazil Muhammad , Ojuni Ochan Dorgi , Miyazaki Kosuke , Ramadhani Zaki Alif , Imamah Nur , Nafisa Layyin , Alfandia Nurlita Sukma , Asmoro Priandhita Sukowidyan , Arsyanda Sifa , Ramadhan Hanifa Maulani , Haidir Vieri Ahmad , Prastya Bayu Andriansyah , Wiyata Wiyata , Indiran Logaiswari , Liu Haibing , Jingjun Lie , Ching Liew Foong , Priambada Swasta , Aini Edlyn Khurotul , Yuliaji Eliana Sandy
Published: November 2023

The digital era has caused a profound change in the paradigm of corporate interaction with consumers. These changes cover how companies communicate, understand, and respond to customer needs. Storytelling can facilitate more positive and meaningful interactions between companies and customers in the digital world. In summary, narrative storytelling significantly influences sustainable entrepreneurship in emerging markets. The creative and authentic use of narratives told and shared allows for the formation of strong bonds between companies and customers. This can motivate customers to take certain actions, such as making a purchase, sharing a story with others, or participating in further interactions with the brand. Remember that as emotional creatures, humans generally respond more positively to messages that evoke emotion. This is why storytelling, which is focused on the emotional aspect, is very effective. Customers want involvement in stories that have an emotional impact, not just being the target of generally monotonous advertising messages. These changes also push companies to seek new communication methods with their audiences. It is where storytelling platforms and channels play a crucial role. Social media is the most common platform that can be used due to its various models (Facebook, Instagram, Twitter, and Linkedin). Interestingly, some companies are starting to communicate with customers through storytelling, which is shown in the form of short videos or blog reviews. Recent podcasts and live streaming are among the increasingly popular platforms used as storytelling media. It indicates that the company's creativity is being tested, especially in building strong bonds between brands and customers.
THE POTENTIAL FUTURE OF ARTIFICIAL INTELLIGENCE IN FOSTERING SUSTAINABLE ENTREPRENEURSHIP WITHIN THE CREATIVE ECONOMY
Authors: Wiyata Wiyata , Indiran Logaiswari , Liu Haibing
Published: November 2023

In the digital age, the creative economy has emerged as a critical driver of economic growth, innovation, and job creation. The creative economy, encompassing industries such as design, art, media, and entertainment, plays a crucial role in economic growth, cultural expression, and social development. With the emergence of artificial intelligence (AI) technologies, there is a growing opportunity to leverage their potential to drive sustainable innovation and entrepreneurship within the creative sector. This chapter begins by providing an overview of the creative economy and its significance in sustainable entrepreneurship. Drawing upon the capabilities of AI, we discuss potential future applications that can foster sustainable entrepreneurship within the creative economy. It explores how AI can assist in optimizing supply chains, enhancing product design and development, enabling personalized customer experiences, and supporting sustainable marketing and distribution strategies. Furthermore, we also discuss the potential of AI in providing personalized recommendations, generating innovative ideas, and predicting consumer preferences. It highlights the transformative role of AI in driving creativity, innovation, and inclusive creative economic growth, paving the way for sustainable and resilient entrepreneurship in the future. By exploring the potential future trajectory of AI in fostering sustainable entrepreneurship within the creative economy, this chapter provides insights and recommendations for entrepreneurs, policymakers, and stakeholders in the creative industry.
DISRUPTIVE INNOVATION IN EMERGING MARKET: SUCCESS EVIDENCE AND ROAD MAP FOR SUSTAINABLE INNOVATION
Authors: Indiran Logaiswari , Wiyata Wiyata , Jingjun Lie , Ching Liew Foong , Liu Haibing
Published: November 2023

Disruptive innovation is seen as a driver of industry transformation and has the potential to reshape entire markets, create new opportunities, and bring about significant societal and economic impact. It encourages continuous improvement, competition, and innovation as organizations strive to adapt and stay ahead in a dynamic and evolving business landscape. Besides, disruptive innovations also foster a culture of continuous improvement and progress by encouraging entrepreneurship and innovation, attracting investment, and fostering a culture of continuous improvement and progress. Therefore, this chapter explores the main antecedent variables that drive disruptive innovation toward sustainable innovation across industries. This study is based on the literature that has been published and presents how disruptive innovation creates a new technological cycle as well as a new business innovation cycle. Disruptive innovation seeks to fundamentally alter technology in order to displace the market rather than supporting the core technology that is already well-established and supported by powerful, well-established companies. Furthermore, this study examined instances of successful disruptive innovation in five companies: CRRC Corporation Limited (CRRC) in China, Xiaomi in China, Ola in India, Reliance Jio Infocomm Limited in India, and Grab in Malaysia. Finally, with a focus on promoting sustainable innovation, this chapter provides valuable insights and contributions to both research and practical applications in the domains of disruptive innovation and emerging markets.
DIGITAL LEARNING CULTURE IN DYNAMIC CAPABILITIES AND FINANCIAL ASPECT AS MEANS FOR CREATIVE INDUSTRY SMES TOWARDS DIGITAL BUSINESS
Authors: Priambada Swasta
Published: November 2023

It is almost certain that the number of Small and Medium-sized Enterprises (SMEs) type is greater than other types of businesses in a country. SMEs have a critical role in the citizen economy in the country because they have the potential to provide a decent income and profession for the majority of citizens, like a handful of people working in the formal sector and large, well-established companies. Digital Business Transformation (DBT) offers many opportunities for businesses to increase their profit. Big companies tend to have adequate resources to undergo DBT. Nevertheless, the potential for DBT is the right of large companies and SMEs. However, it is a challenge for SMEs to undergo DBT while lacking resources. DBT requires the readiness of digital technology infrastructure, business model changes, financial aspects, and the decisions of owners and/ and managers of SMEs to transform. Therefore, there is a need to first understand digital literacies through digital learning cultures and search for further opportunities to have quality development, such as government donating facilities and customer social responsibilities (CSR) from big companies. Creative industry (CI) businesses that are based on thinking, skill, creativity, and talent have enormous beneficial potential if it is supported by digital technologies as an approach to undergoing DBT. In the early steps, they could minimize their operational cost by using free social media as digital marketing. Continuously, by implementing Dynamic capabilities (DCs) to address the challenges of the uncertain business environment through utilizing current and potential resources.
MAKING GREEN ENTREPRENEURSHIP: DEVELOPING SUSTAINABLE ENTREPRENEURSHIP
Authors: Aini Edlyn Khurotul , Yuliaji Eliana Sandy
Published: November 2023

Climate change demands an urgent shift towards sustainable consumption and production. Previously, sustainability was considered secondary for companies. However, it is now acknowledged that for a truly green economy, sustainability principles must be integral from the outset across all industries. This transformation requires innovative entrepreneurs ready to tackle today's social and environmental challenges. Entrepreneurship, traditionally hailed for spurring innovation and economic dynamics, is now also seen as a vehicle for sustainability. With the growing environmental awareness, green entrepreneurship or "ecopreneurship" has taken center stage. These entrepreneurs, blending profitability with societal impact, have the potential to redefine entire industries. They don't merely reduce their environmental footprint but launch initiatives empowering communities, generating jobs, and prioritizing planetary health. The Green Entrepreneurial Orientation (GEO) strategy emphasizes profit and conservation. While green entrepreneurship is under research, deeper insights are needed into balancing environmental objectives with financial success. This chapter delves into the concept of green entrepreneurship with a more comprehensive and holistic perspective, addressing not only the immediate benefits but also the long-term implications and ripple effects on the broader ecosystem.
Diferenças entre o gênero boys love no mangá e nos doramas através da obra Cherry Magic!
Authors: Testoni Paulo
Published: November 2023

O boys’ love é um gênero que nasceu no mangá, passou pelo anime e hoje e vem ganhando as telas através dos doramas. Um dos principais expoentes do gênero nesse formato no Japão é a obra Cherry magic!. O objetivo deste trabalho é fazer uma análise comparativa desta obra entre suas versões em quadrinhos e série televisiva, por conta de recentes conversas sobre o fato de as versões live action do gênero BL terem uma aproximação maior com a realidade gay em detrimento às suas versões em mangá e anime. O que pôde ser observado até então é que a estética dos protagonistas, na versão mangá, se enquadra muito mais no estereótipo de seme (másculo e viril) e uke (delicado e afeminado) do que a versão para televisão. Espera-se com essa pesquisa obter conhecimento acerca das mudanças que o gênero sofre ao ganhar adaptações live action.
Contra o prescritivismo, a fluidez da língua
Authors: Gil Beatriz Daruj
Published: November 2023

O prescritivismo nos discursos sobre a língua não é prática recente. A separação entre bons e maus usos linguísticos sempre expôs atitudes discriminatórias em relação às diversas formas do dizer, contrariando princípios da ciência linguística, por meio dos quais se sabe que a língua varia e muda. E que a variação é propriedade imanente de qualquer língua, por meio da qual se revelam as alterações sociais e históricas de determinada comunidade. Tendo como parâmetros fundamentos da sociolinguística, análise do discurso e da lexicologia, o que se propõe a analisar neste texto é o prescritivismo exposto em algumas escolhas lexicais feitas na matéria jornalística “Rede TV!: Lula usa linguagem ultrapassada ao citar ‘índio’ e ‘opção sexual’”, publicada no portal UOL, em 3/2/2023.