bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of academic-professional hardiness on the subjective well-being of students in socionomic professions
Authors: Shmeleva E. A. , Kislyakov P. A. , Meyerson I.-L. S. , Phan T. K.
Published: November 2023

Introduction. Professions such as doctors, teachers, psychologists, and social workers entail a certain risk to the psychological well-being of both professionals and students due to their educational and professional activities.Aim. The present study aims to explore the factors, which contribute to the development of resilience skills in students of socionomic professions, and which could ensure their psychological well-being in relation to their future professional activities.Methodology and research methods. The theoretical foundations of resilience theory by S. Maddi, D. A. Leontiev, E. I. Rasskazova and others served as subject-scientific guidelines, as well as the approaches of positive psychology to studying subjective well-being of individuals (K. Rogers, M. Seligman). Psychodiagnostic methods such as “Academical-Professional Hardiness”, “Subjective Well-Being Scale”, and “Coping with Stress Questionnaire” (COPE) were employed. The collected data were processed using descriptive statistics, correlation analysis, regression analysis, and confirmatory factor analysis. Research participants. The sample consisted of students majoring in pedagogy, psychology, medicine, and social sciences. The total number of participants was 282, ranging in age from 18 to 20 years old.Results and scientific novelty. The results allow refining knowledge about the characteristics of psychological factors, which contribute to the subjective well-being of students in helping professions. It has been found that the main predictors of subjective well-being among students in socionomic fields of study are academic and professional hardiness, as well as constructive coping styles in dealing with difficulties. Additionally, differentiation in the choice of dominant constructive coping strategies has been observed among students from different academic fields.Practical significance. The obtained results allow refining the understanding of educational and professional resilience as a predictor of students’ psychological well-being in helping professions through productive coping styles, as well as outlining approaches to developing and implementing programmes for enhancing academic and professional hardiness among students in socionomic fields of education (such as pedagogy and education, psychology, social work, medicine). The theoretical and empirical findings of this research can be useful in designing lessons on psychological disciplines.
ROBOT ASSISTED STABILIZATION FOR FLEXIBLE WORKPIECES SUBJECTED TO HIGHLY INTERRUPTED CUTTING
Authors:   Budapest University of Technology and Economics, Department of Applied Mechanics, Toth R. R. , Stepan G. ,   Budapest University of Technology and Economics, Department of Applied Mechanics
Published: November 2023

In many facets of industry, slender workpieces are formed by means of milling processes. These workpieces are especially prone to experience harmful chatter vibrations, which limits quality and productivity. In this paper, a novel solution is proposed where a robotic arm is used to support the workpiece, improving its modal properties and reducing the occurrence of chatter. The paper presents some numerical, analytical and limited experimental results for improving the material removal rate using the robot assisted milling method for low radial immersion processes, such as finishing operations.
Encouraging demand on healthy food in the United States and the diversification of the U.S. Food Market
Authors: Korotkikh Alla
Published: November 2023

Fast food, convenience foods, and ready-to-eat foods are growing in popularity, and eating out has long overtaken the healthier home-based meals in terms of cost and popularity. The obesity epidemic, recognized at the official level, forced the government to take measures to form the right choice of food among the population, and especially children. Expensive government food programs implemented by the USDA, advertising, involvement of the media for explanatory work give their results, but, according to American scientists, they are not effective enough, as the level of obesity in the country continues to grow. In recent years, promising prospects have been given by research in the field of innovative food technologies aimed at the production of protein foods based on alternative sources of raw materials. Many of the new products have already found their place in the national and global food market.
Presidential race - 2024: a portrait in a family interior
Authors: Shvedova Nadezhda
Published: November 2023

On April 25, 2023, Democratic incumbent President Joe Biden identified the central issue of the 2024 presidential election: the video shown launched the presidential campaign. The “striking” moment in it is the similarity with the previous one, four years ago. Central to them are scenes of violence and far-right extremism, both focusing on an issue that will determine the future of the United States. With all the doubts and critical attitude towards the figure of J. Biden as a possible head of the administration of the second term, experts rightly argue that the four years of his first administration “were not the New Deal or the Great Society,” although the most ardent supporters tend to say just that.
At the same time, his achievements are also widely recognized: the infrastructure program that his predecessors could not implement, assistance in the fight against the pandemic, large-scale investments in curbing climate change, and an economy that is growing despite the manifestations of the crisis. It seems that there is much reason in the arguments of those American experts who believe that Americans in 2020 were looking for a remedy for extremism and division. Things haven't gotten much better since then, even without D. Trump in the White House. Differences have allowed the dominant party to “rule the country with little regard for the interests of those loyal to the minority party, and often also little accountability. The result was "two Americas with competing agendas and values". The current race is still about the "character of the country", which is reflected in the diverse palette of colors and shades of the proposed recipes for maintaining the viability and effectiveness of American democracy, among which the institution of the family and politics in relation to it, occupying a system-forming place in the structure of the political system, find themselves in center of events and debates in the new electoral cycle.
Journalist’s Competence as an occupation and society Problem
Authors:   Saratov State University, Sirotinina O.B.
Published: November 2023

The article investigates the journalist’s general, linguistic and ethical competence.
Chronic Recurrent Multifocal Osteomyelitis: A Challenging Diagnosis in The Pediatric Age Group and The Role of Imaging: Sharing A Rare Clinical Experience from Ethiopia, East Africa
Authors: Neknik Getachew Assefa , Tadesse Daniel Admassie , Solomon Daniel Zewdneh
Published: November 2023

Chronic recurrent multifocal osteomyelitis, which was originally described as chronic non-bacterial osteomyelitis is an autoinflammatory bone disorder of idiopathic origin affecting the metaphyseal portion of long bones at multiple sites. This disease entity, which was previously considered to be rare; is now showing a higher incidence according to recent studies. The disease affects children in the age range of 8-11 years and affects females more than males. It is characterized by clinical symptoms persisting more than six months with remissions and episodic exacerbations. Here we present a case of a 12- and half year-old girl who had multiple painful swellings with tenderness in her extremities and clavicle over a 4-year period which exacerbated over the last 18 months prior to diagnosis.
Sistema penal e pandemia: aprofundamento de desigualdades, pactos narcísicos e necropolíticas
Authors: Khaled Junior Salah , Castro John Julia
Published: November 2023

O presente artigo apresenta um debate sobre o sistema penal brasileiro nos tempos pandêmicos. Especificamente, contextualiza desigualdades, racismo e cárcere; discute a Recomendação 62 do Conselho Nacional de Justiça (CNJ), no que tange a sua recepção sociojurídica e suas possibilidades como veículo de desencarceramento. Por fim, as questões fáticas e jurídicas apresentadas são articuladas ao referencial teórico da necropolítica e do pacto narcísico da branquitude. Utilizou-se uma metodologia que considera conjuntamente dados empíricos e reflexões teóricas com base na revisão bibliográfica da literatura pertinente, para buscar compreender a realidade específica do cárcere na pandemia. Os resultados levam à conclusão de que os Poderes da República são corresponsáveis pela manutenção do “estado de coisas inconstitucional” dos presídios brasileiros, bem como por seu incremento durante a pandemia.
A resposta jurisdicional dos Tribunais Regionais Federais brasileiros aos discursos de ódio na internet: proteção ou violação aos direitos fundamentais dos grupos vulneráveis?
Authors: Leal da Silva Rosane , Domingues Pablo
Published: November 2023

A presente pesquisa objetivou analisar as respostas dos Tribunais Regionais Federais (TRFs) do Brasil para os casos envolvendo discurso de ódio, questionando-se tanto a abordagem referente à conceituação e natureza jurídica dessas práticas, quanto se as decisões evidenciavam preocupação com sua propagação na internet. Para enfrentar tal problema de pesquisa utilizou-se abordagem qualitativa e quantitativa, investigando-se as decisões publicadas nos sites dos referidos Tribunais por meio das palavras-chave “discurso de ódio” e “internet”, busca realizada sem considerar marcadores temporais e aspectos processuais. O método de procedimento adotado foi o monográfico, com estudo dos casos evidenciados nas decisões judiciais. Como técnica de pesquisa empregou-se a análise documental do material empírico encontrado, contrastado com as definições literárias sobre discurso de ódio e papel da internet como canal difusor. Identificou-se a concentração de grande número de ocorrências no TRF-4, destacando-se a violência contra indígenas, tema selecionado para análise qualitativa. Concluiu-se que a natureza jurídica dessa forma de violência ainda continua carente de um enfrentamento mais consistente por parte de muitos julgadores, o que prejudica a proteção dos direitos fundamentais dos integrantes do grupo atingido. A vulnerabilidade se agrava com a  difusão da violência por meio da internet, variável desconsiderada nos casos investigados.
Apresentação
Authors: Boff Salete Oro
Published: November 2023

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The Effect of Taekwondo Gym Instructors Teaching Styles on Parents' Behavior
Authors:   The World Society of Taekwondo Culture, Shi Yue , Jeong Seunghoon
Published: November 2023

The purpose of this study is to identify the importance of the Taekwondo instructors teaching styles and the specific relationship between the various variables constituting the parents' behavior, and to provide basic data to activate the Taekwondo gym and increase the educational effect. For the purpose of this study, a total of 500 copies of the questionnaire were collected, and 495 copies of the data were used for the actual result analysis. SPSS 26.0 was used as a data processing method. As a result of the analysis, first, the teaching directing type, positive compensation type, social support behavior type, and democratic behavior type had significant influence on parental satisfaction of parental behaviors. Second, teaching directing type had significant influence on loyalty of parental behaviors. Third, teaching directing type, positive compensation type, social support behavior type, and democratic behavior type had significant influence on adherence intention of parental behaviors. Fourth, teaching directing type, social support behavior type, and positive compensation type had significant influence on recommendation intention of parental behaviors.
Formulation and Activity Testing of a Preparation of Cherry Fruit (Muntingia calabura L.) Syrup as Acute Antidiarrhea in Mice
Authors: Musfirah Widya Suci , Rahim Abdul , Fachreza Homely , Ani Karmelita , Syahira Syifa
Published: November 2023

The problem of diarrhea is an important problem to overcome, especially in the Samarinda area, East Kalimantan Province. The number of diarrhea cases is increasing every year. In 2021, there were 34,436 cases nationally and 4,706 cases in Samarinda. Viruses and bacteria can cause diarrhea. The cherry plant has antibacterial and antidiarrheal properties because of its Alkaloid, flavonoid and tannin content. This research focuses on investigating the potential of syrup from the secondary metabolite juice of cherry fruit syrup in curing acute diarrhea in male Wistar rats. The research method used was to compare 5 groups with varying concentrations of cherry syrup. Measurements include assessing when the diarrhea started, how often the diarrhea occurs, its texture, severity, and how long the diarrhea lasts. Research shows that cherry syrup has a positive effect in reducing diarrhea symptoms such as bowel movement frequency, consistency, weight and duration. Based on the results of research conducted, it shows that cherry fruit syrup (Muntigia calabura L.) can treat acute diarrhea.
Yann Martel’s The High Mountains of Portugal: Symbolic Landscapes within the Profound Journey of Grieving and Recovery
Authors:   The Korean Society For Teaching English Literature, Yun Claudia Sangmi
Published: November 2023

The present study delves into Yann Martel’s The High Mountains of Portugal, a narrative that intricately weaves the journey of three individuals, each from different eras and age groups, as they grapple with loss and subsequently seek to overcome the resulting grief. While on the surface, their shared experience of family loss may seem unique, it echoes the universal sentiment of grief - a sentiment all too familiar to every individual. This analysis unpacks the three protagonists’ sequential emotional healing, illustrating the universality of the recovery process. Martel’s masterful narrative doesn’t just lay out their individual stories; it intricately divides a single overarching narrative among them, culminating in a meta-narrative that reveals the larger picture towards the end. Rich in symbolic elements, the novel extends a multifaceted canvas, inviting readers to delve into myriad themes and subjects. The layered narrative, combined with Martel’s impeccable story-telling skills, sets this work apart. By showcasing the intertwined stories of loss, recovery, and introspection, The High Mountains of Portugal emerges as a paramount literary piece, holding immense academic value.
Poetry and Contemplative Science
Authors:   The Korean Society For Teaching English Literature, Son Hyesook , Han Shin-Il
Published: November 2023

This study aims to demonstrate how contemplative science and poetic language can be combined to improve learners’ awareness and achieve harmony and balance between their mind and body. A contemplative science that seeks to encompass the wholeness of human beings must incorporate a language that allows learners to raise ontological, epistemological, and semantic questions to develop their awareness of self, others, and the world in which they live and to expand individual experiences into universal values. An innovative education model is proposed in this study, which combines the representative meditation program, MBSR with poetry reading and expressive writing. After explaining why poetry can be the best language for meditation, this essay presents a few selected poetry texts, the following questions for writing exercises, and the analysis of participants’ descriptive responses in their self-checklist.
Chlorinated paraffin metabolism and its importance for understanding CP toxicity
Authors: Darnerud Per Ola
Published: November 2023

Chlorinated paraffins (CPs) are industrial chemicals with broad use as plasticizers and components in paints, cutting and drilling oil additives. The research interest in CPs has recently increased, not least due to the progress in analytical techniques and the globally reported large production volumes of CPs. The adverse effects on CPs in biota and in man are being reported in an increasing number of articles and the mechanism of toxicity is being discussed. Whether the metabolism of CPs could increase their toxicity is, however, still an unsolved question. In this Perspective paper, CP metabolism is discussed and arguments pointing to the important role of metabolic enhancement in CP toxicity are highlighted.
Pre-operative Malnutrition in Patients with Ovarian Cancer: What are the Clinical Implications? Results of a Prospective Study
Authors: Nasser Sara , Bilir Esra , Derin Xezal , Richter Rolf , Grabowski Jacek P , Ali Paulina , Kulbe Hagen , Chekerov Radoslav , Braicu Elena , Sehouli Jalid
Published: November 2023

Background: Malnutrition was associated with worse survival outcomes, impaired quality of life, and deteriorated performance status across various cancer types. We aimed to identify risk factors for malnutrition in patients with epithelial ovarian(EOC) and impact on survival.
Methods: In our prospective study, we included the patients with primary and recurrent EOC, tubal or peritoneal cancer conducted. We assessed serum laboratory parameters, body mass index, nutritional risk index, nutritional risk screening score(NRS-2002), and bio-electrical impedance analysis.
Results: We recruited a total of 152. Patients >65 years-old, with ascites of >500 ml, or with platinum-resistant EOC showed statistically significant increased risk of malnutrition when evaluated by NRS-2002(p-values = 0.014, 0.001, and 0.007, respectively). An NRS-2002<3 was an independent predictive factor for complete tumor resectability (p=0.009). The patients with NRS-2002≥3 had a median overall survival(OS) of seven months (95% CI=0-24 months), as compared to the patients with NRS-2002<3 where median OS was 46 months(p=0,001). Phase angle(PhAα)≤ 4.5 was the strongest predictor of OS.
Conclusion: Malnutrition is an independent predictor of incomplete cytoreduction in study population. It is an independent prognostic factor for poor OS. Preoperative nutritional assessment is an effective tool in identification of high-risk groups within EOC characterized by poor clinical outcome.
Factors Associated with Candidiasis in Pemphigus Vulgaris Patients: Results from a Retrospective Study in Two Second‐Care Hospitals in Mexico
Authors: Tirado-Sánchez Andrés , Bonifaz Alexandro , Frías De León María Guadalupe
Published: November 2023

Background: Infections are a major cause of morbidity and mortality in patients with pemphigus vulgaris (PV). One of the most common infections in these patients is candidiasis. This is probably due to the use of systemic immunosuppressant, including oral and intravenous corticosteroids, mainly in megadoses (pulse therapy), although it is unknown if there are other associated factors in addition to immunosuppressive treatment. We determine the factors associated with candidiasis in PV patients in two Second-Care hospitals in Mexico. Methods: We reviewed 100 cases with PV. Cases were randomly selected from the databases of two second-care hospitals between January 2010 and December 2019 (10 years). The primary endpoint was the incidence of candidiasis in patients with PV. Results: One hundred patients with PV were enrolled in this retrospective study. Candidiasis was observed in 79 patients (79%). A maximum corticosteroid dose of 55 mg/day during the last year (p = 0.001) and higher neutrophil/lymphocyte ratio were associated with candidiasis in patients with PV (p = 0.001). Conclusion: Risk factors favoring candidiasis in patients with PV are not only related to the use of corticosteroids, but also to demographic factors, the activity of the disease, and the systemic inflammation associated with autoimmunity.
Utilizing Molecular Simulation to Examine Nanosuspension Stability
Authors: Latham Andrew P. , Levy Elizabeth S. , Sellers Benjamin D. , Leung Dennis H.
Published: November 2023

Drug nanosuspensions offer a promising approach to improve bioavailability for poorly soluble drug candidates. Such formulations often necessitate the inclusion of an excipient to stabilize the drug nanoparticles. However, a rationale to choose the correct excipient for a given drug candidate remains unclear. To gain molecular insight into formulation design, this work first utilizes molecular dynamics simulation to computationally investigate drug-excipient interactions for a number of combinations that have been previously studied experimentally. We find that hydrophobic interactions drive excipient adsorption to drug nanoparticles, and that the fraction of polar surface area serves as a predictor for experimental measurements of nanosuspension stability. To test these ideas prospectively, we applied our model to an uncharacterized drug compound, GDC-0810. Our simulations predicted that salt forms of GDC-0810 would lead to more stable nanosuspensions than the neutral form; therefore, we tested the stability of salt GDC-0810 nanosuspensions and found that the salt form readily formed nanosuspensions even without excipient. To avoid computationally expensive simulations in the future, we extended our model by showing that simple, two-dimensional properties of the single drug molecule can be used to rationalize nanosuspension design without simulation. In all, our work demonstrates how computational tools can provide molecular insight into drug-excipient interactions, and aid in rational formulation design.
Awareness of Forensic Odontology among dental students and faculty in Cyprus
Authors: Lambrou-Christodoulou Persefoni , Giannakopoulos Kostis , Kaklamanos Eleftherios G
Published: November 2023

This study sought to evaluate the awareness, comprehension, and practices concerning Forensic Odontology among dental students and faculty at a Dental School in Cyprus. An online, cross-sectional, descriptive survey was disseminated to the entirety of dental students and faculty of the School of Dentistry, European University Cyprus, in November 2022. Of those surveyed, 47 faculty members and 304 students responded, yielding response rates of 66.2% and 80%, respectively. The survey revealed that 87% of faculty and 65% of students were familiar with Forensic Odontology. A noteworthy 94% of faculty and 85% of students recognized teeth as DNA repositories. A high percentage, 98% of faculty and 89% of students, acknowledged the role of Forensic Odontology in the identification of criminals and deceased individuals. Awareness of age estimation through dental eruption patterns was evident in 85% of faculty and 81.6% of students. A substantial proportion (80% of faculty) maintained dental records, while 78% of students recognized the importance of dental record-keeping in ensuring quality care. Interestingly, 57% of students and 64% of faculty were aware of the possibility of dentists testifying as expert witnesses. The majority, 95.7% of faculty and 85% of students, concurred that physical harm, scars, and behavioral alterations predominantly indicate child abuse. The survey underscored a robust awareness of Forensic Odontology among respondents. Despite faculty's comprehensive understanding, there's a pronounced need to bolster their inclination towards attending relevant seminars. Emphasis on improved record-keeping practices for potential forensic applications is paramount.
Using Beta Function and Factorization to Find New π-Series
Authors: Guo-Jie Li
Published: November 2023

Using the method of the beta function, Sun has recently evaluated some series of the type $\sum_{k=0}^{\infty}(ak+b)x^k/\binom{mk}{nk}$.

By factorization of the polynomial $t^{m-n}(1-t)^n-x$, we will give a general method to find new $\pi$-series.
Syncytial Nets vs. Chemical Signaling: Emerging Properties of Alternative Integrative Systems
Authors: Moroz Leonid
Published: November 2023

Here, we critically evaluate the communication and integrative mechanisms in ctenophores or comb jellies, the descendants of the earliest animal lineage. Ctenophores convergently evolved their neuro-muscular systems compared to other animals. Besides the canonical neural organization with distinct synapses, recent 3D electron microscopy reconstruction revealed unique syncytial-type connectivity in some neuronal populations, providing additional support for the independent origins of neurons in ctenophores. Furthermore, it was proposed that non-synaptic transmission is the distinct characteristic of ctenophores, in contrast to other metazoans and Cajal’s neuronal doctrine, highlighting Golgi’s reticular theory. However, the astonishing diversity and higher information capacity of classical synapses and volume transmission indicate that chemical signaling is the hallmark of neural and other integrative systems regardless of their origins.
Using Machine Learning Methodology to Model Nutrient Discharges from Ports: a Case Study of a Fertilizer Terminal
Authors: Lappalainen Suvi-Tuuli , Kotta Jonne , Tombak Mari-Liis , Tapaninen Ulla
Published: November 2023

Abstract: Marine eutrophication is a pervasive and growing threat to global sustainability. Thereby nutrient discharges to the marine environment should be reduced to a minimum. When fertilizers are loaded to vessels in ports, a significant amount of nutrients are released into the sea, but so far these actions have received little attention.

Here, we employed the Boosted Regression Trees modeling (BRT) to define relationships between fertilizer loading, loading area, rain intensity and nutrient discharge to the marine environment and then used the established relationships to predict daily nutrient discharge due to fertilizer loading. The studied subject was a port in the Gulf of Finland, where significant amount of both nitrogen and phosphorus are loaded to vessels.

BRT models accounted for a significant proportion of the variability of nutrient discharge. As expected, the nutrient discharge increased with the amounts of fertilizers loaded and the intensity of rain. On the other hand, with increasing loading area the amounts of total nitrogen discharge increased, but phosphorus discharge decreased. The latter result may be due to different char-acteristics of the loading areas of different terminals.

The model predicted that at the studied port the total nitrogen and phosphorus discharge into the marine environment due to fertilizer loading was 272,906 and 196 kg per year, respectively. Im-portantly, the developed model can be used to predict nutrient loads for different future scenarios to propose the best mitigation methods for nutrient discharges to the sea.
Evaluating Ecosystem Service Value Changes of Mangrove Forests in Guangxi, China During 2016–2020
Authors: Wang Kedong , Zhang Xiaohai , Zhao Chuanpeng , Zhang Rong , Wang Zongming , Jia Mingming
Published: November 2023

Mangrove forests play a vital role in maintaining the ecological balance of coastal regions. Ac-curately assessing changes in their ecosystem service value (ESV) requires more than precise mangrove distribution data, an appropriate set of evaluation methods is also needed. In this study, we obtain the spatial distribution and structural changes of mangrove forests based on Sentinel-2 imagery and build a mangrove forest ESV evaluation system by combining spatial pattern and the millennium ecosystem services. The results showed that: (1) the area of mangroves in Guangxi increased from 6245.15 ha in 2016 to 6750.01 ha to 2020, with a net increase of 504.81 ha which mainly concentrated in Lianzhou Bay, Tieshan Harbour and Dandou Bay; (2) the ESV of mangrove forests was 379.85 million U.S. dollars (USD) in 2016 and 413.13 million USD in 2020; (3) the value of fishery, soil conservation, wave absorption, and pollution purification comprise the largest proportion of the ESV of mangrove forests. From 2016 to 2020, mangroves in Guangxi had demonstrated a positive development trend and was undergoing a process of recovery. Results and conclusions of this study provide valuable insights and information to facilitate a more profound comprehension of the relationship between the mangrove forest and its ecological significance.
Differential Gene Expression of Malaria Parasite in Response to Red Blood Cell-Specific Glycolytic Intermediate 2,3-Diphosphoglycerate (2,3-DPG)
Authors: Balau Ana , Sobral Daniel , Abrantes Patrícia , Santos Inês , Mixão Verónica , Gomes João Paulo , Antunes Sandra , Arez Ana Paula
Published: November 2023

Innovative strategies to control malaria are urgently needed. Exploring the interplay between the Plasmodium sp. parasites and host red blood cells (RBC) offers opportunities for novel antimalarial interventions. Pyruvate kinase deficiency (PKD), characterized by heightened 2,3-diphosphoglycerate (2,3-DPG) concentration, has been associated with protection against malaria. Elevated 2,3-DPG levels, a specific mammalian metabolite, may hinder glycolysis, prompting us to hypothesize its potential contribution to PKD-mediated protection. We investigated the impact of the extracellular supplementation of 2,3-DPG on the Plasmodium falciparum intraerythrocytic developmental cycle in vitro. Results showed an inhibition of parasite growth, resulting from significantly less progeny from 2,3-DPG-treated parasites. We analyzed differential gene expression and the transcriptomic profile of P. falciparum trophozoites, from in vitro cultures submitted or not submitted to the action of 2,3-DPG, using Nanopore Sequencing Technology. The presence of 2,3-DPG in the culture medium was associated to a significant differential expression of 71 genes, mostly associated to GO terms nucleic acid binding, transcription, or monoatomic anion channel. Further, several genes related to the cell cycle control were downregulated in treated parasites. These findings suggest that the presence of this RBC-specific glycolytic metabolite impact the expression of genes transcribed during the parasite trophozoite stage and the number of merozoites released from individual schizonts, which supports the potential role of 2,3-DPG in the mechanism of protection against malaria by PKD.
Influence of Acoustic Streams on the Efficiency of Ultrasonic Particle Agglomeration
Authors: Khmelev Vladimir Nikolaevich , Shalunov Andrey Victorovich , Nesterov Viktor Aleksandrovich , Terentiev Sergey Aleksandrovich
Published: November 2023

The article is devoted to the study of ultrasonic agglomeration of PM2.5 in uniform and non-uniform ultrasonic fields. The possibility of increasing the efficiency of ultrasonic agglomeration by initiating acoustic streams in a resonant non-uniform ultrasonic field is shown. A non-uniform ultrasonic field with zones of high and low sound pressure levels formed using a bending-oscillating disk transmitter made it possible to initiate acoustic vortex-type streaming that promote the movement of particles into the nodal areas of a standing wave and between them. The efficiency of ultrasonic treatment was determined indirectly by the degree of inertial trapping of agglomerates. It has been established that the impact of an non-uniform ultrasonic field in comparison with the impact of a uniform ultrasonic field makes it possible to increase the efficiency of inertial capture of agglomerates PM2.5 from 89% to 95%, PM1.5 from 85% to 92%, PM0.5 from 76% to 85%.

The results obtained made it possible to propose a design for an agglomeration chamber, which allows for a multiple increase in the productivity of ultrasonic processing of a gas-dispersed flow.
Literature Review: Implications of Early Marriage on Human Development
Authors: Mujahidah Annisatul , Rusli Budiman , Sugandi Yogi Suprayogi
Published: November 2023

Early marriage is a phenomenon that has an impact on various aspects of life which then affects human development. This study aims to conduct a literature review on the implications of early marriage on human development. The method used in this study is the SLR (Systematic Literature Review) method. Data collection was carried out by documenting all literature that met the research inclusion requirements. The literature obtained as many as 25 articles from the Google Scholer database with the help of Harzing's Publish or Perish application. From this literature study, it was found that the phenomenon of early marriage has implications for the human development index based on health indicators and life expectancy, education, and welfare. Another finding is that women are the most disadvantaged from the impact of early marriage. Things that can be done to deal with the phenomenon and impact of early marriage include formal and non-formal education, strengthening access to health and education services, creating empowerment programs, and strengthening regulations and legal protection.
Hypersurfaces in a Euclidean Space with a Killing Vector Field
Authors: Guediri Mohammed , Deshmukh Sharief
Published: November 2023

An odd-dimensional sphere admits a killing vector field, induced by the transform of the unit normal by the complex structure of the ambiant Euclidean space. In this paper, we study orientable hypersurfaces in a Euclidean space those admit a unit Killing vector field and find two characterizations of odd-dimensional spheres. In first result, we show that a complete and simply connected hypersurface of Euclidean space Rn+1, n>1 admits a unit Killing vector field ξ that leaves the shape operator S invariant and has sectional curvatures of plane sections containing ξ positive satisfies S(ξ)=αξ, α mean curvature if and only if n=2m−1, α is constant and the hypersurfaces is isometric to the sphere S2m−1(α2). Similarly, we find another characterization of unit sphere S2(α2) using the smooth function σ=g(S(ξ),ξ) on the hypersurface.
Predicting Operating Income via a Generalized Operating Leverage Model
Authors: Lambert Sherwood Lane , Krieger Kevin , Mauck Nathan
Published: November 2023

We propose a generalized, practitioner-oriented operating leverage model for predicting operating income using Standard and Poor’s Compustat items: SALE (net sales), COGS (cost of sales), DP (total depreciation and amortization), XSGA (selling, general, and administrative expenses), and OIADP (operating income after depreciation and amortization). Prior research finds that OIADP = SALE - COGS - DP - XSGA; hence, our model includes all aggregate revenues and expenses comprising OIADP. Also, prior research finds COGS is “much less” sticky than DP and XSGA; hence, we use COGS as a proxy for total variable costs and DP and XSGA as proxies for sticky fixed costs. We introduce a new adjustment to the textbook operating leverage model so that SALE-to-COGS remains constant for the reference and forecast periods. Also, inspired by prior research, we introduce adjustments to DP and XSGA for cost stickiness. We find our generalized operating leverage model improves estimates of changes in next-quarter and next-year OIADP compared to textbook operating leverage predictions, which are special cases of our model.
A Comprehensive Study of Renal Angiography in Dogs with Chronic Kidney Disease
Authors: Arumugam Kishorekumar , M Chandrasekar , G R Baranidharan , S Giridharan , H Pushkin Raj , S Kavitha
Published: November 2023

Renal angiogram is a promising tool for diagnosing renal vasculature and structural alterations in renal diseases. In renal diseases, the vascular changes were observed earlier than the structural and other changes. However, the literature on angiograms in kidney diseases was limited. Six client-owned dogs with chronic kidney diseases with International Renal Interest Society (IRIS) stage II and III were selected for this study. Under general anesthesia, the femoral arterial catheterization was performed. With a Cobra (C2) catheter, Iohexol saline (50:50) was administered to evaluate the vascular changes of Renal failure, using selective and non-selective angiograms. The procedures were completed successfully with minimal complications. Serum biochemistry and urine protein creatinine ratio were estimated sequentially and quality of life was monitored. Due to contrast agent complications, a dog died within 14 days and necropsy was conducted. Though the renal angiogram has complications, it is a reliable tool for the diagnosis of vasculature changes associated with kidney diseases, in veterinary medicine.
Effect of Combined Addition of CeLa and GdY on Microstructure and Mechanical Properties of As-Cast Al-Cu-Mn Alloys
Authors: Zhang Haiyang , Wu Mingdong , Li Zeyu , Huang Yang , Xiao Daihong , Huang Lanping , Liu Wensheng
Published: November 2023

In this study, the effects of combined addition of CeLa and GdY on microstructure and mechanical properties of as-cast Al-4Cu-1Mn alloys were investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopies (TEM) and tensile testing. The results show that the minor addition of CeLa and GdY leads to the refinement of grain size. The addition of CeLa results in the formation of supersaturated vacancies in the Al matrix, whereas the addition of GdY leads to a decrease in the precipitation temperature of the Al2Cu phase. The combined CeLa and GdY addition can significantly increase ultimate tensile strength (UTS) while losing only a small amount of elongation (EL). Compared with the unmodified alloy, the grain size and SDAS of the alloy (0.2 wt% CeLa + 0.1 wt% GdY) were diminished by 67.2% and 58.7%, respectively, while maximum hardness and UTS rose by 31.2% and 36.9%, correspondingly.
Insights into the Biological Roles of Artichoke Extracts: Implications in Intestinal, Cardiovascular, and Neurodegenerative Diseases
Authors: Porro Chiara , Benameur Tarek , Cianciulli Antonia , Vacca Mirco , Chiarini Margherita , De Angelis Maria , Panaro Maria Antonietta
Published: November 2023

Several chronic diseases derive from metabolic, genetic, or inflammatory causes and often these causes are interconnected. Pharmacological treatments, although effective, often lead to unpleasant side effects. In this context, preventive approaches are of growing interest. The literature data of recent years support that the dietary intake of bioactive compounds can positively influence the biological functions of an organism.
Among the bioactive compounds in the diet, polyphenols are widely recognized for their beneficial effects on health, as useful compounds for preventing/combating a series of pathologies related to lifestyle, metabolism, and aging. The artichoke (Cynara scolymus L.), a member of the Asteraceae family, is widely used in the food and herbal medicine fields for its beneficial properties. Artichokes are rich in polyphenols (including cynarin), flavonoids and their derivatives, and, for this reason, they have aroused interest in their pharmacological properties. The best-known activity of polyphenols is antioxidant activity. Through it, they help to neutralize free radicals, preventing cellular damage and the subsequent risk of conditions such as cancer, diabetes, and heart disease. Related to the antioxidant action we find the anti-inflammatory activity. This is an important benefit since chronic inflammation is a cause or contributory cause of many chronic diseases.
Although many scientific results are of great interest and potential, there are still gaps to be filled.
In this review, we report and discuss new insights providing documented evidence regarding the benefits of the artichoke compounds and their possible use to support the pharmacological treatment of pathologies associated with inflammation.
Values of Tolerance Through Religious Learning at Al-Hikmah Lasem Islamic Boarding School: Concepts, Strategies, and Challenges
Authors: Fatah Ahmad , Syukur Fatah , Ihsan Ihsan , Saadah Hilyatus
Published: November 2023

This study aims to describe and analyze the internalization of tolerance values through religious learning at the Al-Hikmah Lasem Islamic Boarding School. The type of research used is field research, namely research that requires researchers to travel to the field to observe phenomena in a scientific context. The subjects in this study were Kiai, Ustaz, head of the boarding school, administrators, and students of Al-Hikmah Lasem. The criteria for students involved by researchers to determine research subjects were those who had lived in Islamic boarding schools for a range of two to four years. The results of this study revealed that the internalization of tolerance values at the Al-Hikmah Lasem Islamic boarding school was achieved through habituation strategies and exemplary strategies. The internalization process was carried out through religious learning both textually through book studies and contextually through examples and procedures for socializing and tolerance with the community. Supporting factors for achieving the internalization of the tolerance value included the motivation frequently given by caregivers, Ustaz, and administrators to the students of the Al-Hikmah Lasem Islamic Boarding School; the condition or environment of the Al-Hikmah Lasem Islamic Boarding School; the existence of supporting facilities at the Al-Hikmah Lasem Islamic Boarding School. Meanwhile, the inhibiting factors comprised the different backgrounds of students and the lack of interaction between students and the Chinatown community.
Development of standards for the provision of children’s population with ultrasound examinations.
Authors:   Children’s Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan, Yunusova E. R. , Khuzikhanov F. V. ,   Kazan State Medical University, Shulaev A. V. ,   Kazan State Medical University, Marapov D. I. ,   Kazan State Medical Academy – Branch Campus of the Russian Medical Academy of Continuous Professional Education
Published: November 2023

Ultrasound examination is the most popular among other diagnostic methods. In pediatrics, ultrasound diagnostics has additional advantages due to its painlessness and lack of radiation exposure. However, there are a number of problems in regulating the activities of ultrasound diagnostics offices and departments, namely the standards for providing the children’s population with ultrasound examinations both for children’s city clinics and for children’s hospitals. These indicators are necessary for planning ultrasound activities in pediatrics and monitoring the availability of ultrasound in pediatric medical organizations. To calculate the indicator of the provision of ultrasound services to the child population, annual reports of ultrasound examination rooms and departments in 13 pediatric medical organizations in Kazan and Naberezhnye Chelny, including 10 clinics and 3 hospitals, were analyzed. The annual number of ultrasound scans was compared to the size of the attached child population (for clinics) and the number of hospitalized patients (for hospitals). It turned out that the number of ultrasound scans varies significantly in different clinics. The average number of ultrasound scans per year in the clinic was calculated – the coverage of the child population in ultrasound, which amounted to 918 ultrasound scans per 1000 children’s population in the clinic, and in the hospital there are 114–390 ultrasound scans per 100 hospitalized patients. Using the presented algorithm for calculating the need for ultrasound in a children’s hospital and in a children’s clinic, it becomes possible to plan the activities of ultrasound diagnostic rooms and departments in pediatrics, and the ability to control the availability of ultrasound examinations for children.
Legal regulation of test purchases in the provision of paid medical services: relevance of the issue for medical organizations.
Authors:   Expert on the issues of regulatory and legal regulation of health care activities, Piven D. V. , Kitsul I. S. ,   Irkutsk State Medical Academy of Postgraduate Education – the branch of the Russian Medical Academy of Continuing Professional Education of the Ministry of Health of the Russian Federation, Ivanov I. V. ,   FSBI «National Quality Institute» of Roszdravnadzor.
Published: November 2023

The article presents a detailed analysis of the Federal Law of July 31, 2020 № 248-FZ “On State Control (Supervision) and Municipal Control in the Russian Federation” in the context of such a control (supervisory) event as a test purchase in the provision of paid medical services. Heads of medical organizations need to know and take into account in their activities that grounds for conducting a control purchase of paid medical services may arise, including when supervisory authorities carry out control measures without interaction with controlled persons, and as a result of a preventive visit. Legislative consolidation of test purchases as a method of control (supervision) over the provision of paid medical services requires medical organizations to ensure their constant readiness in terms of knowledge by employees of the medical organization of the established procedure and mechanisms for its implementation. The implementation by Roszdravnadzor bodies of a test purchase within the framework of federal state control (supervision) of the quality and safety of medical activities once again confirms that the issues of providing paid medical services should be constantly in the spotlight when medical organizations conduct internal control of the quality and safety of medical activities. The authors substantiate that organizing and conducting control purchases of paid medical services is a very promising control (supervisory) measure for its active use by supervisory authorities.
Actual issues of the organization of professional retraining of physical rehabilitation specialists (kinesiospecialists) in the context of a new model of medical rehabilitation.
Authors:   Higher School of Rehabilitation and human health of the Institute of Clinical Medicine of the Nizhny Novgorod State University named after N. I. Lobachevsky» (UNN), Builova Т. V. , Zverev Y. P. ,   Higher School of Rehabilitation and human health of the Institute of Clinical Medicine of the Nizhny Novgorod State University named after N. I. Lobachevsky» (UNN), Balchugov V. А. ,   Higher School of Rehabilitation and human health of the Institute of Clinical Medicine of the Nizhny Novgorod State University named after N. I. Lobachevsky» (UNN)
Published: November 2023

The system of medical rehabilitation in Russia undergoes significant transformation which is reflected in the Federal Program «Optimal for health restoration medical rehabilitation in the Russian Federation». In such situation the issues of personnel training in the field of medical rehabilitation are becoming extremely relevant. The difficulties that arise along this path are associated with the interdisciplinarity of medical rehabilitation and the necessity to train specialists with medical education (doctors and nurses) as well as with higher non-medical education: physical therapists, ergotherapists, medical psychologists and medical speech therapists (according to the Order No. 788n of 31.07.2020). These allied health specialties are new for Russia but they are responsible for the main practical activity in the implementation of an individual medical rehabilitation plan. The difficulties in training non-medical personnel in rehabilitation largely arise from the requirement for them to have both medical and pedagogical competencies and to have the ability to work independently as well as in a rehabilitation team. This article summarizes the three-year experience of training specialists in medical rehabilitation with higher non-medical education at the National Research Nizhny Novgorod State University named after N. I. Lobachevsky. The article presents the main issues of the professional retraining program «Physical rehabilitation (physical therapy)» with a duration of 1020 hours, defines professional competencies, difficult issues of training, formation of practical skills and assessment of professional competencies in this category of students.