bluuebunny/crossref_metadata_2025 huggingface dataset:
Reestruturação metropolitana e dinâmicas imobiliárias: transformações recentes na Região Administrativa Venda Nova de Belo Horizonte-MG
Authors: Diniz Luciano dos Santos , Véras Maura Pardini Bicudo
Published: April 2019

Resumo Este artigo tem como objetivo avaliar o recente processo de reestruturação econômico-espacial implementado pelo Poder Público no Vetor Norte da Região Metropolitana de Belo Horizonte (RMBH) e sua influência na dinâmica imobiliária da Região Administrativa Venda Nova (RAVN). A reestruturação estratégica objetiva a diversificação da base industrial da RMBH, a partir da atração de novos investimentos e do fomento de polos de alta tecnologia. Ambiciona-se, com isso, maior inserção e competitividade dos municípios nos cenários nacional e global. A pesquisa demonstrou que as intervenções procedidas pelo Poder Público incluem grandes obras públicas de infraestrutura e de suporte a serviços, influindo determinantemente na transformação espacial da RAVN, em Belo Horizonte, mediante uma intensa valorização imobiliária e a elitização do espaço.
COMPARISON BETWEEN ABSOLUTE AND RELATIVE POSITIONAL ACCURACY ASSESSMENT - A CASE STUDY APPLIED TO DIGITAL ELEVATION MODELS
Authors: França Leandro Luiz Silva de , Penha Alex de Lima Teodoro da , Carvalho João Alberto Batista de
Published: April 2019

Abstract This paper presents a comparative study between the absolute and relative methods for altimetric positional accuracy of Digital Elevation Models (DEM). For the theoretical basis of this research, the definitions of accuracy (exactness) and precision, as well the concepts related to absolute and relative positional accuracy were explored. In the case study, the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) and the Shuttle Radar Topography Mission (SRTM) DEM were used. In the analysis of the absolute accuracy, 6,568 ground control points from GNSS orbital survey were used, collected through relative-static method. In the relative accuracy, it was used as reference DEM with spatial resolution of 5 meters generated by stereophotogrammetrical process for the Mapping Project of Bahia (Brazil). It was concluded that, once the accuracy of the reference DEM is better than the other two evaluated DEM, the results of the classification for the PEC-PCD for the relative evaluation are equal to or better than the absolute evaluation results, with the advantage to being able to verify the pixel population of the evaluated models, which makes it possible to identify outliers, distortions and displacements, including delimiting regions, which is much less likely with a limited set of control points.
Progressive collapse of regular- and irregular-plan concrete structures in an earthquake
Authors: Ghadamian Ardeshir , Alirezaei Mehdi
Published: April 2019

Progressive collapse, in which local failure of an element causes significant deformations leading to the collapse of a structure, is a catastrophic structural phenomenon that can occur due to natural disasters or human negligence. Common practices in progressive collapse analysis generally prevent this phenomenon due to unusual gravity loads or explosions; however, progressive collapse behaviour due to earthquakes is less evaluated. An experimental methodology was used to study the progressive collapse of concrete structures with an intermediate moment frame both in regular and irregular plan using the alternative load path method and guidelines issued by the US General Services Administration and the US Department of Defense considering three cases of column removal using OpenSees. The investigation studied the function of the structure regarding the rotation of plastic hinges and its robustness. The pushover method was used to cover non-linear static analysis and the time history method was used to perform non-linear dynamic analysis for three-, six- and ten-storey structures in three dimensions. The results showed that structures with irregular plan and low heights are more vulnerable to progressive collapse.
O impacto do financiamento do PRONAF sobre indicadores agrícolas nas lavouras do Estado do Paraná: uma análise de dados em painel
Authors: De Oliveira Renato Alves , Bueno Luciano Ribeiro
Published: April 2019

O objetivo deste estudo foi analisar a influência do PRONAF - Programa Nacional de Fortalecimento da Agricultura Familiar sobre os indicadores agrícolas: produção, área plantada e produtividade das lavouras de subsistências beneficiadas pelo Programa no Estado do Paraná, no período de 2007 a 2012. A pesquisa utilizou um modelo de regressão de dados em painel. As lavouras de subsistência selecionadas que receberam benefícios do Programa no Estado foram: batata, arroz, cana-de-açúcar, feijão, mandioca, soja, café, trigo e milho. As análises da relação entre o montante de financiamento do PRONAF e os indicadores agrícolas apontaram que para a maioria das lavouras o PRONAF teve um efeito negativo, embora muito pequeno, sobre a produção, área plantada e produtividade. Contudo a influência do PRONAF no desempenho da produção e da produtividade do milho e da mandioca foi positivamente significativa.
Hemşirelerde Danışmanlık Becerileri Ölçeği’ni (HDBÖ) Geliştirilmesi: Geçerlik ve Güvenirlik Çalışması
Authors: AYDIN AVCI İlknur , KUMCAĞIZ Hatice
Published: April 2019

Bu çalışmada hemşirelerin danışmanlık becerilerini ölçebilecek geçerlik

ve güvenirlikte bir ölçme aracı geliştirmek amaçlanmıştır. Ölçek için

oluşturulan madde havuzuna son şekli verildikten sonra açımlayıcı faktör

analizi için 204 hemşireye uygulama yapılmıştır. Ölçeğin tek faktörden ve 10

maddeden oluştuğu görülmüştür. Sonrasında 200 hemşire ile Doğrulayıcı Faktör

Analizi (DFA) yapılmıştır. DFA ile tek faktörlü yapının uyum indeksi

değerlerinin kabul edilebilir sınırlar içerisinde olduğu görülmüştür (χ2=94.785,

sd=33, χ2/sd= 2.872, RMSEA=0.097, GFI=0.92, AGFI=0.86, CFI=0.92 ve IFI=0.92).

Ölçeğin geçerliği AFA ve DFA yapılmak suretiyle incelenmiştir. Ölçeğin

güvenilirliği ise Cronbach alfa katsayısı ve Split-half ile incelenmiştir.

Cronbach alfa .88,  Split-half ise .86

olarak hesaplanmıştır. Elde edilen sonuçlara göre HDBÖ’nin hemşirelerin

danışmanlık becerilerini belirlemek amacıyla kullanılabileceğini göstermiştir.
Comparação estética entre sistemas cerâmicos sobre substrato escurecido
Authors: Maroli Angélica , Federizzi Leonardo , Spazzin Aloisio Oro , Borges Radaelli Manuel Tomás
Published: April 2019

Objetivo: O objetivo deste trabalho foi avaliar visualmente a possível influência de um substrato escurecido no resultado estético de coroas com infraestruturas de dissilicato de lítio ou zircônia. Metodologia: O delineamento foi observacional, transversal e descritivo. Para o experimento, foi selecionado um paciente com necessidade de coroas totais no 11 e 21, onde um dos dois elementos deveria ser escurecido. Uma coroa de dissilicato de lítio foi confeccionada sobre o substrato sem alteração de cor. Para o elemento escurecido foram confeccionadas uma coroa de dissilicato de lítio e uma de zircônia, criando-se duas situações clínicas. Sem conhecimento de qual material foi usado, os avaliadores responderam a um questionário que comparava o resultado estético das coroas de dissilicato de lítio ou zircônia com a coroa de dissilicato de lítio sobre o substrato normal, assim como as duas situações clínicas entre si. No total, 20 cirurgiões-dentistas participaram como avaliadores. Os avaliadores julgaram as restaurações como excelentes, aceitáveis ou inaceitáveis e, após, foi realizada uma análise descritiva das avaliações. Resultados: Os resultados demonstraram que houve diferença estética entre as restaurações de dissilicato de lítio e de zircônia, sendo que o dissilicato de lítio não conseguiu bloquear a cor do substrato, mesmo sendo utilizada uma pastilha opaca (MO). Conclusão: Concluiu-se que em casos de substrato escurecido está indicada a utilização de uma infraestrutura com opacidade suficiente, como a zircônia, podendo ocorrer diferenças visualmente perceptíveis e inaceitáveis caso seja utilizado um material translúcido como o dissilicato de lítio.
First Experience with Extracorporeal Membrane Oxygenation in Iran, under Difficult Conditions
Authors: Hossein Ahmadi Zargham , Salehi Farshid , Niusha Shanay , Raoufy Mohammad Reza , Farzanegan Behrooz , Afshar Ali , Mafhoomi Yadollah , Faghih Abdollahi Zahra , Radmand Golnar , Ansari Aval Zahra , Jahangirifard Alireza
Published: April 2019

Background: Extracorporeal membrane oxygenation (ECMO) provides hemodynamic and oxygenation support in critical conditions. The commencement of this modality in Iran coincided with severe economic constraints across Iran.
Methods: This retrospective study was performed in Masih Daneshvari Medical Center from 2010 to 2015, during which period, sanction-related limitations in the import of equipment prompted us to integrate a Medtronic or Stöckert head pump console into a Maquet ECMO Oxygenator so as to sustain the ECMO program. Comparisons were performed between successful and unsuccessful ECMO procedures and survivors. Factors associated with unsuccessful ECMO were evaluated with a multivariate logistic regression.
Results: Thirty-three (68.8%) patients were male and 15 (31.2%) were female. The mean age of the patients was 35±16.6 years. Thirty-seven (77.1%) patients were weaned off ECMO successfully; the rate was higher than that in previous studies. Totally, 35.4% of the study population survived to hospital discharge. The most common cause of death in all the ECMO patients who were successfully weaned was sepsis. The most common cause of death in the patients who underwent unsuccessful ECMO was multisystem organ failure. The mean ECMO support time was 53.37±46.26 hours. The patients who were alive at discharge were significantly younger (25.5±14.5 vs. 40.2±15.5 y; P=0.002) and had a significantly lower ECMO duration (24 [25–75% interquartile: 18.5–36] vs. 48 [25–75% interquartile: 24–72] h; P=0.044) than the non-survivors.
Conclusion: An assembly of ECMO components from different companies could be done safely, at least for a short period of time.
Catheter-Directed Thrombolysis in Acute Iliofemoral Deep Vein Thrombosis with or without Stenting: A Case Series
Authors: Haji Zeinali Ali Mohammad , Jenab Yaser , Ariannejad Hamid , Kassaian Seyed Ebrahim , Alidoosti Mohammad , Aghajani Hassan , Zafarghandi Mohammad Reza
Published: April 2019

Iliofemoral deep vein thrombosis (IFDVT) is a potentially devastating condition comprising a quarter of all cases of lower extremity DVT. It can lead to serious consequences such as pulmonary embolism, limb malperfusion, and post-thrombotic syndrome (PTS), which is a chronic sequela of IFDVT. We herewith present 18 IFDVT cases managed with catheter-directed thrombolysis at our hospital. Nine of these patients underwent stenting of the involved iliac veins. The remaining 9, who did not receive stenting, had a residual stenosis of more than 50% in the common femoral or iliac veins following the procedure. Based on a final residual stenosis of less than 50% in the iliac veins, we had 9 successful (patients with stenting) and 9 unsuccessful procedures (patients without stenting). In subsequent follow-ups at a median follow-up of 39.5 months, using the Villalta score, while only 2 out of the 9 patients who underwent stenting suffered PTS, 4 patients among the other 9 patients comprising the non-stenting group developed PTS. Our results support the notion that stenting might have a role in decreasing the PTS risk in patients undergoing catheter-directed thrombolysis.
Comparison of atracurium and vecuronium as muscle relaxants for ocular and orthopaedic interventions in dogs
Authors: Kumar Rohit , Kumar Adarsh , Kumar Amit , Tyagi S. P.
Published: April 2019

Twenty adult dogs of either sex, divided into 2 equal groups were used for evaluation of atracurium (0.5 mg/kg IV) and vecuronium (0.1 mg/kg IV) in atropine-butorphanol-diazepam premedicated and propofol (till effect IV) induced dogs which
were further maintained on isoflurane with controlled IPPV mode of the ventilator for positive pressure ventilation. A total of 13 ophthalmic and 7 orthopaedic interventions were done in both the groups. Pulmonary parameters were measured at baseline
(pre-operative), just after induction and at 5, 15, 30 and 45 minutes after the administration of NMBA and the recovery parameters were recorded after weaning from the anaesthetic gas. The eyeballs deviated to the ventro-medial position after the
induction with diazepam and propofol and resumed the central position within 30 seconds of atracurium or vecuronium administration thus, proving highly beneficial for the eye globe and corneal interventions. On a comparative basis, atracurium and
vecuronium provided muscle relaxation for 40.1 ± 4.71 and 37.7 ± 1.01 minutes respectively. Uniform and pronounced muscle relaxation along with excellent sedation was found in both the groups. All pulmonary parameters remained within normal range.
Following discontinuation of the isoflurane, the time taken to bear weight was 38.88 ± 1.45 and 39.63 ± 4.08 minutes in the atracurium and vecuronium groups respectively.
Caracterização de um sistema convectivo de mesoescala por meio de sistema de informações geográficas
Authors: Passos Robson , Preisser Guilherme , Reboita Michelle , Mattos Enrique
Published: April 2019

O uso de Sistema de Informação Geográfica (SIG) é muito difundido na geografia e nos campos das engenharias ambiental e hídrica, mas é pouco conhecido na área de ciências atmosféricas. Nessa última, o SIG pode ser uma importante ferramenta para análises em climatologia, meteorologia sinótica, meteorologia de mesoescala, agrometeorologia, sensoriamento remoto da atmosfera e hidrometeorologia. Nesse contexto, o presente estudo tem dois objetivos: i) classificar o tipo de um sistema convectivo mesoescala, ocorrido em outubro de 2017 entre o Paraguai, Brasil e Argentina, com o auxílio de um SIG, no caso, o Global Mapper 15.0 e ii) apresentar um roteiro para que   possam ser reproduzidas as análises usando o referido software em ciências atmosféricas. O Sistema Convectivo de Mesoescala (MSC) estudado foi responsável por totais elevados de precipitação (50 mm/dia) na fronteira entre Brasil, Argentina e Paraguai. Embora o sistema visualmente se assemelhe a um complexo convectivo de mesoescala, nos critérios analisados ele foi classificado apenas como um sistema com dimensão horizontal mais alongada. O sistema convectivo durante seu desenvolvimento máximo apresentou área de 719.044 km² e excentricidade de 0,5. O procedimento metodológico estabelecido pode ser utilizado para caracterizar intensos sistemas como os SCM e pode ser útil no auxilio de tomadas de decisão pela defesa civil e comunidade local.
POR UMA DESCRIÇÃO DA JUSTIÇA EM LUHMANN
Authors: Lima Fernando Rister de Sousa , Bôas Filho Orlando Villas
Published: April 2019

O propósito deste artigo é descrever a justiça enquanto fórmula de contingência, tal como proposta pelo sociólogo alemão Niklas Luhmann. Para tanto, em um primeiro momento, será necessário apontar a especificidade que o autor atribui à abordagem do direito para, em seguida, sublinhar aspectos essenciais de sua visão acerca da justiça. A pesquisa bibliográfica é o recurso metodológico utilizado para reunir o referencial teórico essencial ao deslinde da problemática, guiada pela ideia de que o direito opera com base no código binário lícito/ilícito e a justiça do sistema jurídico é a fórmula de contingência, cuja finalidade é fornecer consistência e adequação social às decisões jurídicas. Como conclusão, pode-se, primeiramente, afirmar que decisão justa é aquela tomada obrigatoriamente sob o manto da fórmula de contingência, ou seja, com consistência e adequação.
Enhanced Protection of Biological Membranes during Lipid Peroxidation. Study of the Interactions between Flavonoid Loaded Mesoporous Silica Nanoparticles and Model Cell Membranes
Authors: Sadžak Anja , Mandić Lucija , Strasser Vida , Baranović Goran , Domazet Jurašin Darija , Dutour Sikirić Maja , Šegota Suzana
Published: April 2019

Flavonoids, polyphenols with anti-oxidative activity have high potential as novel therapeutics for neurodegenerative disease, but their applicability is rendered by their poor water solubility and chemical instability under physiological conditions. In this study, this is overcome by delivering flavonoids to model cell membranes (unsaturated DOPC) using prepared and characterized biodegradable mesoporous silica nanoparticles, MSNs. Quercetin, myricetin and myricitrin have been investigated in order to determine the relationship between flavonoid structure and protective activity towards oxidative stress i.e. lipid peroxidation induced by addition of hydrogen peroxide and/or Cu2+ ions. Among investigated flavonoids, quercetin showed the most enhanced and prolonged protective anti-oxidative activity. The nanomechanical (Young modulus) measurement of the MSNs treated DOPC membranes during lipid peroxidation confirmed attenuated membrane damage. By applying combination of experimental techniques (AFM, force spectroscopy, ELS, DLS), this work generated detailed knowledge about the effects of flavonoid loaded MSNs on the elasticity of model membranes, especially under oxidative stress conditions. Results from this study will pave the way towards the development of innovative and improved markers for oxidative stress-associated neurological disorders. In addition, the obtained could be extended to designing effective delivery systems of other high potential bioactive molecules with an aim to improve human health in general.
Fully Non-Contact Hybrid NDT Inspection for 3D Defect Reconstruction Using an Improved SAFT Algorithm
Authors: Selim Hossam , Trull José , Delgado Prieto Miguel , Picó Rubén , Romeral Luis , Cojocaru Crina
Published: April 2019

Non-destructive testing of metallic objects that may contain embedded defects of different sizes is an important application in many industrial branches for quality control. Most of these techniques allow defect detection and its approximate localization, but very few give enough information for its 3D reconstruction. Here we present a hybrid laser – transducer system that combines remote laser-generated ultrasound excitation and non-contact ultrasonic transducer detection. This fully non-contact method gives access to separating scan areas on different object’s faces and defect details from different angles/perspectives can be analysed. This hybrid system can analyse the whole object’s volume data and allow a 3D reconstruction image of the embedded defects. As a novelty for the signal processing improvement, we use a 2D apodization window filtering technique, applied along with the synthetic aperture focusing algorithm in order to remove the undesired effects of side lobes and wide-angle reflections of propagating ultrasound waves, thus, enhancing the resulting 3D image of the defect. We provide both qualitative and quantitative volumetric results with high accuracy and resolution compared with conventional techniques.
Natural Products from Cyanobacteria: Focus on Beneficial Activities
Authors: Demay Justine , Bernard Cécile , Reinhardt Anita , Marie Benjamin
Published: April 2019

Cyanobacteria are photosynthetic microorganisms that colonize diverse environments worldwide, ranging from ocean to freshwaters, soils, and extreme environments. Their adaptation capacities and the diversity of natural products (molecules, metabolites, or compounds) that they synthesize support the cyanobacterial success for the colonization of their respective ecological niches. Although cyanobacteria are well-known for their toxin production and their relative deleterious consequences, they also produce a large variety of molecules that exhibit beneficial properties with high potential for various fields of application (e.g., synthetic analog of the dolastatin 10 used against Hodgkin lymphoma). The present review specially focuses on the beneficial activities of cyanobacterial molecules described so far. Based on an analysis of 670 papers, it appears that more than 90 genera of cyanobacteria have been found to produce compounds with potential beneficial activities, most of them belonging to the orders Oscillatoriales, Nostocales Chroococcales, and Synechococcales. The rest of the cyanobacterial orders (i.e., Pleurocapsales, Chroococcidiopsales, and Gloeobacterales) remain poorly explored in terms of their molecular diversity and relative bioactivity. The diverse cyanobacterial molecules presenting beneficial bioactivities belong to 10 different chemical classes (alkaloids, depsipeptides, lipopeptides, macrolides/lactones, peptides, terpenes, polysaccharides, lipids, polyketides, and others) that exhibit 14 major kinds of bioactivity. However, no direct relation between the chemical class and the bioactivity of these molecules has been demonstrated. We further selected and specifically described 50 molecule families according to their specific bioactivities and their potential uses in pharmacology, cosmetology, agriculture, or other specific fields of interest. This up-to-date review takes advantage of the recent progresses in genome sequencing and biosynthetic pathway elucidation, and presents new perspectives for the rational discovery of new cyanobacterial metabolites with beneficial bioactivity.
Cucurbita argyrosperma Seed Extracts Attenuate Angiogenesis in a Corneal Chemical Burn Model
Authors: Estrella-Mendoza María Fernanda , Jiménez-Gómez Francisco , López-Ornelas Adolfo , Pérez-Gutiérrez Rosa Martha , Flores-Estrada Javier
Published: April 2019

Cornea severe inflammation produces opacity or even perforation, scarring, and angiogenesis, resulting in blindness. The cornea can be used to study the effect of new anti-angiogenic chemopreventive agents. We researched the anti-angiogenic effect of two extracts, Methanol (Met) and Hexane (Hex), from the seed of Cucurbita argyrosperma, in the inflamed corneas. The corneas of Wistar rats were alkali-injured and treated intragastrically for seven successive days. Clinical manifestation as opacity score, corneal neovascularization (CNV) area, re-epithelialization percentage, and histological evaluation were performed. Inflammatory (COX-2, NF-κB, and IL-1β), and angiogenic (VEGF-A, VEGFR1, VEGFR2) markers were assessed by immunohistochemistry. Cox-2, Il-1β, and Vegf-a mRNA levels were also determined. After treatments, we observed slim corneal thickness with lower opacity scores and low cell infiltration compared to untreated rats. Treatment also accelerated wound healing and decreased CNV area. The staining of inflammatory and angiogenic factors was significantly decreased. These effects are related to a down-expression of Cox-2, Il-1β, and Vegf. These results suggest that intake of C. argyrosperma seed can be used to attenuate the angiogenesis secondary to inflammation in corneal chemical damage.
Biological Treatments of Oilfield Produced Water: A Comprehensive Review
Authors: Lusinier Nicolas , Seyssiecq Isabelle , Sambusiti Cecilia , Jacob Matthieu , Lesage Nicolas , Roche Nicolas
Published: April 2019

Crude–oil extraction leads to the production of water, called produced water (PW). PW–flow rate increases along with the time of operation, up to more than 20 times the flow rate of crude oil. PW is often considered toxic because of its complex composition. At the moment, only dispersed hydrocarbons are targeted by water regulation. However, as regulations are becoming more stringent, they are also targeting dissolved compounds and/or the whole effluent toxicity. Consequently, PW treatments have to be more efficient, also allowing for high reliability of installations and high compactness (offshore processes). Biological treatments are often considered to offer the best compromise between removal performances and operating costs. However, their lack of compactness is unsuitable for offshore implementation. Hybrid processes, defined here as the combination of two or more processes, show promising performance and should be further studied to overcome the drawbacks noted in the case of other technologies.
Co-Culture Systems for the Production of Secondary Metabolites: Current and Future Prospects
Authors: Tan Zin Quat , Leow Hui Yin , Lee David Charles Weerasingam , Karisnan Kanakeswary , Song Adelene Ai Lian , Mai Chun Wai , Yap Wai Sum , Lim Swee Hua Erin , Lai Kok Song
Published: April 2019

Microorganisms are the great sources of Natural Products (NPs); these are imperative to their survival apart from conferring competitiveness amongst each other within their environmental niches. Primary and secondary metabolites are the two major classes of NPs that help in cell development, where antimicrobial activity is closely linked with secondary metabolites. To capitalize on the effects of secondary metabolites, co-culture methods have been often used to develop an artificial microbial community that promotes the action of these metabolites. Different analytical techniques will subsequently be employed based on the metabolite specificity and sensitivity to further enhance the metabolite induction. Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography (GC)-MS are commonly used for metabolite separation while Nuclear Magnetic Resonance (NMR) and Mass Spectrometry (MS) have been used as tools to elucidate the structure of compounds. This review intends to discuss current systems in use for co-culture in addition to its advantages, with discourse into the investigation of specific techniques in use for the detailed study of secondary metabolites. Further advancements and focus on co-culture technologies are required to fully realize the massive potential in synthetic biological systems.
The Extent and Coverage of Current Knowledge of Connected Health: Systematic Mapping Study (Preprint)
Authors: Karampela Maria , Isomursu Minna , Porat Talya , Maramis Christos , Mountford Nicola , Giunti Guido , Chouvarda Ioanna , Lehocki Fedor
Published: April 2019

BACKGROUND

This study examines the development of the connected health (CH) research landscape with a view to providing an overview of the existing CH research. The research field of CH has experienced rapid growth coinciding with increasing pressure on health care systems to become more proactive and patient centered.

OBJECTIVE

This study aimed to assess the extent and coverage of the current body of knowledge in CH. In doing so, we sought to identify specific topics that have drawn the attention of CH researchers and to identify research gaps, in particular those offering opportunities for further interdisciplinary research.

METHODS

A systematic mapping study that combined scientific contributions from research in the disciplines of medicine, business, computer science, and engineering was used. Overall, seven classification criteria were used to analyze the papers, including publication source, publication year, research type, empirical type, contribution type, research topic, and the medical condition studied.

RESULTS

The search resulted in 208 papers that were analyzed by a multidisciplinary group of researchers. The results indicated a slow start for CH research but showed a more recent steady upswing since 2013. The majority of papers proposed health care solutions (77/208, 37.0%) or evaluated CH approaches (49/208, 23.5%). Case studies (59/208, 28.3%) and experiments (55/208, 26.4%) were the most popular forms of scientific validation used. Diabetes, cancer, multiple sclerosis, and heart conditions were among the most prevalent medical conditions studied.

CONCLUSIONS

We conclude that CH research has become an established field of research that has grown over the last five years. The results of this study indicate a focus on technology-driven research with a strong contribution from medicine, whereas the business aspects of CH have received less research attention.
FORMULATION DESIGN AND OPTIMIZATION OF ORAL FLOATING MATRIX TABLETS OF CIPROFLOXACIN HCL BY USING HPMC AND XANTHAN GUM WITH EXPERIMENTAL DESIGN
Authors: Pasa Gourishyam , Choudhury Prasanta Kumar , Panigrahi Ghanshyam
Published: April 2019

The oral floating matrix tablets of Ciprofloxacin Hydrochloride were formulated by Experimental design by using HPMC K100M and Xanthan gum as the retardant polymers each with three different levels with an approach to increase gastric residence and thereby improve drug bioavailability. From FTIR results confirm the absence of chemical interaction between the drug with the excipients used in tablet formulations. Also, there was no shift in the endotherm of in the drug- excipients mixtures indicating compatibility of drug with all the excipients. All the tablets were prepared by effervescent approach in which Sodium bicarbonate was added as a gas generating agent. Floating Matrix tablets were prepared by direct compression method and prepared tablets were evaluated for weight variation, percentage friability, hardness and drug content studies. All the formulations showed compliance with pharmacopeia standards. Floating lag times of all the formulations were within 1 minute and Total floating time of all the formulations were more than 12 hours. In vitro release studies revealed that the release rate decreased with increase polymer proportion of retarding polymers. The formulation CHX8 sustained release of drug for 12 hrs with 20% release of drug after 1hr and more than 97% at the end of 12 hrs. From the Kinetic model it was found that the optimized formulation CHX8 showed linearity in case of Zero order (R2: 0.952) and Higuchi model (R2: 0.948). By fitting data to Korsmeyer-Peppas model and ‘n’ value lying above 0.5 indicating non Fickian release.
Spectrophotometric determination of ranitidine hydrochloride (RNH) in pharmaceutical formulation using 9-fluorenylmethyl chloroformate (FMOC-Cl)
Authors: Elbashir Abdalla Ahmed , Merghani Shahd Moutasim
Published: April 2019

A new, simple and sensitive spectrophotometric method is developed for the determination of ranitidine hydrochloride (RNH). The proposed method is based upon reaction of RNH with 9-fluorenylmethyl chloroformate (FMOC-Cl) in borate buffer of pH 8.0 producing an absorption maximum at 255 nm. All parameters required for the reaction conditions are investigated. Linearity is verified with a range of 2-16 μg/mL and is described by the regression equation y = 61129 x + 0.0354 with a correlation coefficient of 0.9998 (n = 7). The limit of detection (LOD) and the limit of quantification (LOQ) were calculated as per ICH guidelines and were found to be 0.2219 and 0.6724 μg/mL, respectively. The method was successfully applied for the determination of RNH in pharmaceutical formulation. Therefore, the method can be used for routine analysis of RNH in quality control laboratories.
Powder catchment in laser metal deposition
Authors: Siva Prasad Himani , Brueckner Frank , Kaplan Alexander F. H.
Published: April 2019

Laser metal deposition (LMD) of Inconel 718 using a coaxial nozzle is investigated by high-speed imaging. The interaction of individual powder grains with the laser induced melt pool surface and, finally, their catchment in the LMD track is observed. Powder catchment trends are explained by interpreting physical phenomena, such as the melt flow and surface tension. Distinct zones for powder catchment are categorized depending on the position of initial interaction between powder grains and the melt pool. Particles are introduced outside the melt pool ricochet and do not attach to the clad. Particles arriving outside the laser spot, onto the solidifying skin of the melt pool, are caught, and may incorporate. Some particles may remain on the clad surface as surface roughness on the built part. Particles interacting with the laser-irradiated region of the melt pool tend to move toward its center and readily incorporate into the melt. Quantitative analyses of high-speed videos are carried out to measure incorporation time of powder grains in the melt pool, their velocity, and distance traveled.
Tutoría en la educación superior: análisis de la percepción de profesionales y estudiantes en una universidad pública / Tutoring in Higher Education: Analysis of the Perception of Professionals and Students in a Public University
Authors: Yon Guzmán Silvia Estela , Hernández Marín Gloria del Jesús
Published: April 2019

Este estudio descriptivo analiza los significados de experiencias relacionadas al proceso de atención tutorial de una universidad pública de Costa Rica. Esto a partir de una muestra no probabilística integrada por participantes voluntarios: especialistas, profesores, y estudiantes. Se utilizó el estudio de caso y la técnica de entrevista semiestructurada: el instrumento se diseñó con un guion preestablecido de 10 preguntas abiertas diferenciadas. Se procesó la información organizada en unidades de análisis, derivadas de cada pregunta guía, a partir de las cuales se generaron los significados, categorías, temas y relaciones; para el análisis descriptivo se utilizaron las frecuencias y porcentajes de las respuestas ofrecidas por los participantes.
 
Como parte de los resultados, entre las funciones del profesor consejero se destaca la orientación académica y personal, con alto predominio de la académica, que se intensifica en el proceso de matrícula. Dentro de las principales necesidades se externan las académicas, en menor medida las económicas y familiares. Por otro lado, si bien se resalta el papel del profesor consejero por el apoyo que ofrece, los estudiantes demandan mayor atención en el área personal, comunicación e interacción y permanencia del tutor.
Los resultados aquí obtenidos permiten conocer más de cerca la labor tutorial a través de las percepciones que tienen los estudiantes y el profesorado. Los datos alcanzados pueden servir de referencia para desarrollar una propuesta de mejora en el contexto estudiado, así como para contrastar con otras experiencias.
Survival Survey of Lactobacillus acidophilus In Additional Probiotic Bread
Authors: Duc Thang Truong , Hanh Quyen Le Thi , Thuy Hang Hoang Thi , Thien Luan Nguyen , KimThuy Dang Thi , Lieu Dong My
Published: April 2019

Bread is a popular food in the world because of its variety and convenience. Currently, studies on the adding probiotics to bread are limited due to the adverse effects of processing, such as baking temperature, aerobic environment to the probiotic bacteria. The objective of this study was to produce probiotic cream bread, in which Lactobacillus acidophilus was microencapsulated with Alginate 2% (A); Alginate 2% + maltodextrin 1% (AM); Alginate 2% + xanthan gum 0.1% (AX); and Alginate 2% + maltodextrin 1% + xanthan gum 0.1% (AMX). Microcapsules were added to the kernel, conducting encapsulation yield investigations, survival in baking, preservation of bread, and in simulated gastric fluid and simulated intestinal fluid conditions after 8 days of storage. The results showed that the addition of xanthan gum enhanced the encapsulation yield, it reached 92.9% and 92.37% in AMX and AX samples, respectively. The viability of L. acidophilus during baking was decreased by 3.64 and 3.75 Log (CFU/bread) in AMX and AM samples, compared to A and AX which were decreased by 4.75 and 4.44 Log (CFU/ bread). In SGF (Simulated Gastric Fluid) and SIF (Simulated Intestinal Fluid) conditions, the AMX microcapsules provide the best probiotic protection among the four tested carriers. The combination of xanthan gum and maltodextrin in alginate matrix, eventually leading to having dual efficiency: First, xanthan gum would act as buffers that reduce acid activity; Second, maltodextrin acting as a protective agent of L. acidophilus against high temperature as well as potential prebiotic that improve the viability of probiotic.
The results of a three-year research program on assessment of primary diagnostic issue of congenital heart defects in children under 1 year and the availability of cardiac surgical care in the Kyrgyz Republic
Authors: Kudaiberdiev Taalaibek , Akhmedova Irina , Imanov Bakytbek , Abibillaev Damirbek , Kadyraliev Zhunus , Shoonaeva Nurgul , Satarova Chinara , Imanalieva Gulzada , Tilemanbetova Kayirnisa , Zhakypova Zarema , Tursunbekova Gulnaz
Published: April 2019

In this article, the results of 3-year research program on primary diagnostics of congenital heart defects in children < 1 year of age are presented.
Perbedaan Representasi Sosial Tentang Siswa Junior antara Siswa Kelas XII SMAN A Dan SMAN B
Authors: Lubis Asri Christine , Prawiro Ferdinand
Published: April 2019

Seniority is a social phenomenon that is naturally found in the school environment.  At SMAN A, seniority has been abused by senior students. Meanwhile, at SMAN B, seniority has been applied positively. This difference indicates that there were unique meanings given to the junior students by the seniors in the two schools. This study aims to understand these differences by using social representations theory with the structural approach. The study was conducted in two stages. Free association method was used in the first stage to discover the attributes of social representation of junior students. Researchers asked 206 participants at SMAN A and 198 participants at SMAN B to write down the things that came to mind when they read the word "junior students". The second stage aims to identify the attributes of the central core and peripherals. A total of 92 participants from SMAN A and 92 participants from SMAN B were asked to fill out a questionnaire. The data were analyzed with the centrality test and chi-square test. The results show 18 attributes of social representation of junior students. At SMAN A, attributes of central core are [1] charming appearance and [2] the orientation of students and attribute of peripherals are [1] negative behaviors, [2] the targets of mistreatment, [3] unique appearance, [4] peeve, [5] new students, and [6] paltry. At SMAN B, attributes of central core are [1] charming appearance, [2] the orientation of students, [3] good relationships, and [4] positive behaviors and attributes of peripherals are [1] cool, [2] need to be nurtured, [3] new students, and [4] different generations. This results show differences in social representation of junior students in twelfth-graders at SMAN A and SMAN B. This study suggests that SMAN A make innovation in school regarding to student activities by looking up to SMAN B.
IMPROVING TAX ADMINISTRATION THROUGH TECHNOLOGY INNOVATION IN NIGERIA (A STUDY OF FEDERAL INLAND REVENUE SERVICE)
Authors: ADEYEYE Gbadegesin Babatunde
Published: April 2019

This study investigates the impact of technology innovation on tax administration in Nigeria. Primary Data were collected through the use of structured questionnaire administered on 219 staffers of Federal Inland Revenue Service (FIRS) to elicit their responses. Descriptive statistics, Analysis of Variance (ANOVA) and Regression Model were used for the data analysis. The R value depicts that the use of information technology accounted for (76.3%) improvement in tax administration in Nigeria. The results strongly support the TPB in predicting the intention of users to adopt electronic tax-filing systems. The results also demonstrate the significant effect that computer self-efficacy has on behavioural intention through perceived ease of use, perceived usefulness, and perceived risk of use. Based on the findings of this study, implications for electronic tax filing are discussed. Finally, conclusion and recommendations were made based on the findings of the study.
Evolution Mechanism of Off-site Construction Ecosystem Based on the LotkaäóñVolterra Model: A Case Study
Authors: Xie Fangyun , Mao Chao , Liu Guiwen
Published: April 2019

Off-site construction (OSC) is an alternative method to conventional construction for solving problems of high energy consumption, high pollution, and poor efficiency. OSC is a reform trend for the global construction industry. The emergence of OSC can influence the production relations in traditional construction industry chain, thereby changing the roles of stakeholders in such new construction sector. Given that most developing countries at present are still in the initial stage of adopting OSC, their construction industry is far from forming healthy and symbiotic ecosystem and highly efficient industry chain. Therefore, the scientific and rapid development of OSC becomes restricted. This study analyzes the mechanism of OSC ecosystem, reduces the vague understanding of OSC by stakeholders, and provides a reference for the strategy planning of stakeholders. From the perspective of bionics, this study aims to (1) establish an OSC ecosystem based on the theory of ecology and delimit the role of stakeholders in the OSC ecosystem, and (2) establish a LotkaäóñVolterra model for the OSC evolution. The OSC development in Beijing is used as an example. Data are collected and models are verified to discuss the state, trend, and turning point of the OSC evolution. The findings of this study can help stakeholders in comprehensively understanding the inherent historical development of OSC and provide a reference for the government decision making.
IoT-based Inventory Control System Framework for Panelized Construction
Authors: Wang Meng , Ma Yongsheng , Altaf Mohammed Sadiq , Al-Huseein Mohamed
Published: April 2019

Modular construction and panelized construction have been promoted and recognized globally as advanced construction techniques. Not only have these construction methods been utilized in the oil and gas industry, but they have also successfully been introduced into the residential construction industry. In North America, the panelized construction technique has become popular particularly for wood-frame wall panels. However, although utilizing this advanced construction method can greatly improve the working environment and productivity, the conventional mentality in construction, which overlooks the value of an automated management system to support offsite prefabrication and onsite installation, hinders its potential. An Internet of Things (IoT)-based management system can capture all dynamic data in real time and effectively synthesize it along the supply chain associated with various types of resources. Eventually, with the assistance of a feature-based modeling method, IoT-based information collection can be merged into an Enterprise Resource Planning (ERP) system. Although highly dynamic market demands result in continual changes in the production plan, schedule, and inventory levels, adopting an IoT-based system accounts for the dynamic changes characteristic of this advanced construction method in order to maximize production. Therefore, in this paper, a conceptual framework for an IoT-based inventory control system is proposed in order to enhance the production and satisfy Just-in-Time inventory principle. IoT-based real-time technology is introduced and the development of supportive software is described. Part of the proposed IoT-based inventory control system is implemented as a case study in a panelized construction manufacturing facility, ACQBUILT, Inc., based in Edmonton, Alberta, Canada.
Early identification of school attendance problems: How helpful are Dutch laws, policies, and protocols?
Authors: Brouwer-Borghuis Marije L. , Heyne David A. , Vogelaar Bart , Sauter Floor M.
Published: April 2019

The identification of emerging school attendance problems (SAPs) is highly important. Early identification permits early intervention, which reduces the likelihood of SAPs becoming established and contributing to additional problems. In the short term, SAPs can contribute to academic and social-emotional problems for the young person and stress for the family, and they place extra demands upon school resources. In the longer-term, SAPs can lead to school drop-out which contributes to problems for the community at large. Local, national, and international efforts aimed at the identification of emerging SAPs are thus a priority. This paper commences with a review of national laws and policies in the Netherlands that have a bearing on the identification of SAPs. Two Dutch protocols relevant to the identification of SAPs are also considered. Thereafter, we discuss the strengths and weaknesses of Dutch laws, policies, and protocols, paying particular attention to the question of whether they satisfactorily stimulate early identification of SAPs. The paper concludes with recommendations about ways to improve early identification in the Netherlands. These recommendations can stimulate thinking among educational professionals and policy-makers in other countries.
Politik Hukum Kriminalisasi dan Dekriminalisasi di Bidang Hak Cipta
Authors: Handoko Duwi
Published: April 2019

Substansi Undang-Undang Hak Cipta di Indonesia, meliputi aspek hukum privat dan hukum publik. Dalam tulisan ini, hanya dikaji unsur hukum publik, khususnya terkait kriminalisasi dan dekriminalisasi. Penelitian ini dilandasi oleh keingintahuan dalam mengungkap dasar pemikiran kriminalisasi dan dekriminalisasi untuk mencapai tujuan, yaitu setiap orang harus mengetahui batasan-batasan terhadap suatu perbuatan yang dapat dipidana. Pendekatan yang digunakan dalam penelitian ini adalah secara kualitatif dengan alat pengumpul data berupa studi kepustakaan. Kriminalisasi dan dekriminalisasi di bidang hak cipta adalah bagian dari Politik Hukum Pidana Indonesia. Dasar pemikiran proses kriminalisasi dapat ditinjau dari dua aspek, yaitu kriminalisasi murni dan bukan kriminalisasi murni. Dasar pemikiran proses dekriminalisasi adalah pidana tidak dijatuhkan atas perbuatan pelanggaran hak cipta yang tidak memiliki kepentingan secara komersial. Pemerintah hendaknya secara terus menerus memberikan edukasi kepada pencipta atau pemegang hak cipta dalam menyikapi delik aduan di bidang hak cipta. Pencipta hendaknya terus berkarya dan memahami bahwa tidak semua pelanggaran hak cipta dapat dinyatakan sebagai kejahatan dan terhadap pelakunya disebut penjahat. Hal itu karena ada legalisasi terhadap pelanggaran itu sendiri.
Establishment of a Transgenic Zebrafish Expressing GFP in the Skeletal Muscle as an Ornamental Fish
Authors: Rezaei Mohammad , Basiri Mohsen , Hasani Seyedeh-Nafiseh , Asgari Behrouz , Kashiri Hadis , Shabani Ali , Baharvand Hossein
Published: April 2019

Background: Transgenic animals have a critical role in the advancement of our knowledge in different fields of life sciences. Along with recent advances in genome engineering technologies, a wide spectrum of techniques have been applied to produce transgenic animals. Tol2 transposase method is one of the most popular approaches that were used to generate transgenic animals. The current study was set out to produce an ornamental fish, which express enhanced green fluorescent protein (EGFP) under control of mylpfa promoter by using Tol2 transposase method. Materials and Methods: Polymerase chain reaction (PCR) cloning method was performed to insert zebrafish myosin promoter (mylpfa) into Tol2-EGFP plasmid at the upstream of EGFP. In vitro transcription method was used to prepare the transposase mRNA. The Tol2-EGFP plasmid and transposase mRNA were then co-injected into the one-cell stage of zebrafish zygotes. After two days, the fluorescent microscopic analysis was used to select transgenic zebrafishes. Result: Our data showed that the optimum concentration for recombinant Tol2 vector and transposase mRNA were 50 ng/ul and 100 ng/ul, respectively. The results also revealed that the quality of embryos and quantity of injected construct had the important effects on Tol2 transposase method efficiency. Conclusion: Data showed that Tol2 transposase is an appropriate method to generate zebrafish transgene. Our finding also showed that mylpfa promoter is a strong promoter that can be used as a selected promoter in the ornamental fish industry. [GMJ. 2019;8:e1068]