bluuebunny/crossref_metadata_2025 huggingface dataset:
Fast Photo Stimulus Responsive Ultralong Room-temperature Phosphorescence Behaviour of Benzoic Acid Derivatives @ Boric acid
Authors: Cheng Yi , Fan Wenwen , Wang Longjie , Liu Yanxiong , Wang Qiufeng , Yang Shaoxiong , Qin Yu , Shi Yonggang , Liu Shixi , Zheng Liyan , Cao Qiue
Published: May 2021

Ultralong room-temperature phosphorescence (URTP) materials with photo stimulus responsive (named URTP-PSR) behavior are amazing but still rarely reported due to their great requirements on the crystal structure, complicated synthesis process, long photo-activation and deactivation time. Herein, a series of URTP-PSR materials were prepared by a facile doping process, which involved one-pot heating treatment of benzoic acid derivatives and boric acid to form an amorphous phase. The URTP-PSR materials displayed gradually enhanced ultra-long phosphorescence upon prolonged deep UV light illumination under ambient conditions to restricts the vibration and rotation of molecular. Impressively, both of the photo-activation and deactivation process can be finished within several seconds, which was much fast than previously reported URTP-PSR materials. The optical properties can be repeated many times without obvious loosing performance, suggesting excellent fatigue resistance behaviors of the URTP-PSR materials. Simultaneously, the URTP-PSR materials also displayed excellent atmosphere stability, which still maintained good optical properties even under oxygen atmosphere. Furthermore, owing to the high processability and light-stimulus emission, the URTP-PSR materials have been utilized as security ink for anti-counterfeiting pattern application. It's worth mentioning that all the raw materials are commercialized and low-cost, which could be purchased directly and benefit for the practical application. These findings break through many limitations of existing dynamic RTP materials, such as complicated preparation process, fine crystal structure, long photo-activation and deactivation time, and furthermore expand the scope of dynamic smart-response materials for great potential in many fields.
Impact of COVID-19 Pandemic on Migraine in Migraine Buddy Users
Authors: Kato Yuji , Poh Weijie , Horvath Zsolt , Cadiou François , Shimazu Tomokazu , Maruki Yuichi
Published: May 2021

Background: The nature of COVID-19 pandemic measures has altered the clinical management of migraine, and has also created barriers to evaluate the impact of such measures of migraine patients. Using the Migraine Buddy smartphone application, we assessed the impact of the COVID-19 pandemic on migraine in users residing in the United States.Methods: Migraine Buddy is a smartphone application by individuals to record their migraine headache episodes, characteristics, and coping mechanisms. For this study, anonymized self-reported data from 163,176 adult Migraine Buddy users in the United States between January 2020 and May 2020, were analyzed for migraines associated with stress. A stress-related migraine is defined as one in which stress or anxiety was reported as a trigger or symptom. A questionnaire on the impact of COVID-19 on migraine and its management was also completed by 1,322 users in the app between April 2020 and May 2020. Results: 88% of the Migraine Buddy database extract and 83% of the respondents are female, with a mean age of 36.2 years. The proportion of stress-related migraine attacks peaked at 50% on March 17, although the number of migraine attacks decreased. This followed the declaration of the COVID-19 national emergency on March 13 and a spike in the number of COVID-19 cases in the United States. Questionnaire respondents felt that the following added more stress: social isolation (22.6%), information overdose (21.2%), access to essentials (food, medication, etc.) (18.7%), and financial concerns (17.8%). To help manage migraine during COVID-19, respondents suggested stress and diet coaching programs and resources (medical articles, etc.) (34.0%), having the option for home delivery of medication (30.6%) and tele-consulting (25.5%).Conclusion: Here, we report the change in the proportion of self-reported stress-related migraine in relation to evolution of the COVID-19 pandemic, as well as its impact of migraine management. Our data will help increase the understanding of patients' needs and help with planning and execution of mitigating strategies.
Experimental Study on High Performance Concrete of Ultra-Deep Mines on the Coast of Eastern China
Authors: Quan Daolu , Ji Hongguang , Su Xiaobo , Liu Juanhong , Chen Dongsheng , Fu Zhen
Published: May 2021

To solve the problem of ultra-deep mines on the coast of eastern China under the complex external environment of "high in-situ stress, high osmotic pressure, and strong corrosion", the high-performance concrete shaft wall structure with “high strength and low impact liability” was proposed. The field test study of the high-performance concrete shaft lining was carried out in-1120m ingate and-1114m to-1124m shaft in Sha-ling Gold Mine, and its stress and deformation were monitored and analyzed. Finally, according to the Von-Mises strength criterion and the thick-walled cylinder theory, the calculation formula of bearing capacity of HPC shaft wall was deduced. The results showed that: (1) On the 5th day after in-situ casting, the stress of high-performance concrete tends to be stable. Compared with ordinary concrete, high-performance concrete showed good early strength (2) The high-performance concrete shaft lining strain changes smoothly, and concrete strain can be divided into three stages: rapid growth stage, slow growth stage, and stable stage. (3) Under the external environment of "high in-situ stress, high osmotic pressure, and strong corrosion", the − 1120m ingate and − 1114m~-1124m shaft lining of Sha-ling Gold Mine supported by high-performance concrete had uniform stress and good mechanical properties, which can provide a reference for similar engineering support design.
Temporal Assessment of the Medicinal Plant Trade in Public Markets of the State of Paraíba, Northeastern Brazil
Authors: Ferreira Ezequiel da Costa , de Lucena Reinaldo Farias Paiva , Bussmann Rainer W. , Paniagua-Zambrana Narel Y. , Cruz Denise Dias da
Published: May 2021

Background: Open and public markets are the main providers of medicinal plants in urban environments. The present study evaluated the medicinal plants sold in public markets in different municipalities in the mesoregions of the state of Paraíba, northeast of Brazil, and the possible variations in the supply of these plants in the markets over the course of a year. Methods: Thirty-five traders of medicinal plants were interviewed in four mesoregions of different climatic and phytophysiognomic characteristics (ranging from Caatinga to Atlantic Forest). The versatility of the species sold was elucidated using the Relative Importance Index (IR), and the set of species sold by each informant in each mesoregion was compared with each other by similarity analysis Anosim-One, and by the analysis of main coordinates. Results: Punica granatum , Zingiber officinale , and Myracrodruon urundeuva were the species with the highest RI. The analysis of similarity showed distinct differences between the Sertão and all other mesoregions. The analysis highlighted that a mesoregion had an intermediate similarity pattern in relation to the others, for which we suggest the term "biocultural ecotone" or “cultotone”. The absence of 88 species in at least one of the trading locations at some stage of the fieldwork was recorded. Conclusions: The commercialized species do not seem to have a presence / absence relationship in relation to the period of the year or the mesoregion, and there seem to have been changes in the inventory of plants commercialized in markets in recent years. We identified an intermediate zone of knowledge and use of species commercialized between the studied localities.
Does Discount Matter in Indonesia e-Wallet Race? A Qualitative Study on Generation Z e-Wallet Preferences During Pandemics
Authors: Prasasti Arum , Aulisaina Fatwah Inna , Rahman Hakim Muhamad Arif
Published: May 2021

The research aimed to examine the intention of Generation Z when using e-wallet for payments and the influence of discounts towards using e-wallet in the time of pandemics. The research used the qualitative method with total data of 22 students, collected using in-depth interviews through WhatsApp free call. The result shows that discount gives an impact on Generation Z in choosing the e-wallet, but a long-term loyalty is not guaranteed. The finding demonstrates that there are other influential factors for Generation Z to choose e-Wallet, namely ease of use, interrelated apps with the e-wallet, the security system, and cashless society. The limitations of the research lie in the relatively small numbers of respondents. Due to pandemics with physical distancing requirements, the research only carries out on data collected from 22 students from Economics Faculty in the State University of Malang, Indonesia. However, the research provides an insightful analysis for digital payments industry as a reference. It is expected that fellow researchers and academicians use the research as a fundamental to further investigate digital payments, especially amongst Generation Z in Indonesia or other parts of the world.
Therapeutic Potential, Synthesis, Patent Evaluation and SAR Studies of Thieno[3,2-d]pyrimidine Derivatives: Recent Updates
Authors: Islam Farhana , Quadery Tasdique M.
Published: May 2021

Thieno[3,2-d]pyrimidine ring framework comprises a significant class of heterocyclics that
serve as a promising platform showing different pharmacological activities. The interest in
thieno[3,2-d]pyrimidine cores for pharmaceutical products makes this scaffold an exceptionally helpful
building block for organic chemistry. This review presents current research on thieno[3,2-
d]pyrimidines and elucidates their biological importance in anti-cancer, anti-infectious, anticonvulsant,
anti-diabetic, CNS, and osteoporosis drug discoveries. Patents on the thieno[3,2-
d]pyrimidines are also elaborated as a piece of useful information. Here, we additionally focus on the
synthesis of this vital ring and the discovery of new thieno[3,2-d]pyrimidines.
Targeting Brain Cancer Cells by Nanorobot, a Promising Nanovehicle: New Challenges and Future Perspectives
Authors: Kishore Chandra , Bhadra Priyanka
Published: May 2021

Advances in the field of nanotechnology and nanomedicine have resulted in the development
of novel diagnosis and potential treatment for different types of diseases, including brain cancer.
Nanomaterials are smaller in size, having a higher area to volume ratio, and can be conjugated
with other molecules. Nanomaterials are excellent transport vehicles that can easily cross the extracellular
matrix, cell membrane, and by crossing the blood-brain barrier, they can deliver the drugs
to the remote and inaccessible internal parts of the brain. A nanorobot is a device that ranges in
size from 0.1-10 micrometer and resembles in size to a red blood cell. Nanorobot is a smart robot
that can patrol the bloodstream, recognize the specific target, and can release a tiny but deadly cargo
of drugs or nanoparticles to kill the cancer cells. With the multidisciplinary approach of biotechnology,
molecular biology, electronics, bioinformatics-based computer simulation, and molecular
medicine, a self-sufficient nanodevice can be developed for brain tumor diagnosis and treatment.
This review article discusses the current applications and future promises of nanorobots in brain
cancer therapy.
Patient-Provider Text Messaging and Video Calling Among Case-Managed Patients Living With HIV: Formative Acceptability and Feasibility Study (Preprint)
Authors: Fonner Virginia A , Kennedy Samuel , Desai Rohan , Eichberg Christie , Martin Lisa , Meissner Eric G
Published: May 2021

BACKGROUND

Patient-provider communication is critical for engaging and retaining people living with HIV in care, especially among medically case-managed patients in need of service coordination and adherence support. Expanding patient-provider communication channels to include mobile health modalities, such as text messaging and video calling, has the potential to facilitate communication and ultimately improve clinical outcomes. However, the implementation of these communication modalities in clinical settings has not been well characterized.

OBJECTIVE

The purpose of this study is to understand patient and provider perspectives on the acceptability of and preferences for using text messaging and video calling as a means of communication; perceived factors relevant to adoption, appropriateness, and feasibility; and organizational perspectives on implementation within an HIV clinic in South Carolina.

METHODS

We conducted 26 semistructured in-depth interviews among patients receiving case management services (n=12) and clinic providers (n=14) using interview guides and content analysis informed by the Proctor taxonomy of implementation outcomes and the Consolidated Framework for Implementation Research. Participants were purposefully sampled to obtain maximum variation in terms of age and gender for patients and clinic roles for providers. The data were analyzed using quantitative and qualitative content analyses.

RESULTS

Most patients (11/12, 92%) and providers (12/14, 86%) agreed that they should have the capacity to text message and/or video call each other. Although consensus was not reached, most preferred using a secure messaging app rather than standard text messaging because of the enhanced security features. Perceived benefits to adoption included the added convenience of text messaging, and potential barriers included the cost and access of smartphone-based technology for patients. From an organizational perspective, some providers were concerned that offering text messaging could lead to unreasonable expectations of instant access and increased workload.

CONCLUSIONS

Patients and providers perceived text messaging and video calling as acceptable, appropriate, and feasible and felt that these expanded modes of communication could help meet patients’ needs while being safe and not excessively burdensome. Although patients and providers mostly agreed on implementation barriers and facilitators, several differences emerged. Taking both perspectives into account when using implementation frameworks is critical for expanding mobile health–based communication, especially as implementation requires active participation from providers and patients.

CLINICALTRIAL
Improving the Usability and Safety of Digital Health Systems: The Role of Predictive Human-Computer Interaction Modeling (Preprint)
Authors: Paton Chris , Kushniruk Andre W , Borycki Elizabeth M , English Mike , Warren Jim
Published: May 2021

UNSTRUCTURED

In this paper, we describe techniques for predictive modeling of human-computer interaction (HCI) and discuss how they could be used in the development and evaluation of user interfaces for digital health systems such as electronic health record systems. Predictive HCI modeling has the potential to improve the generalizability of usability evaluations of digital health interventions beyond specific contexts, especially when integrated with models of distributed cognition and higher-level sociotechnical frameworks. Evidence generated from building and testing HCI models of the user interface (UI) components for different types of digital health interventions could be valuable for informing evidence-based UI design guidelines to support the development of safer and more effective UIs for digital health interventions.
A Roadmap for Automating Lineage Tracing to Aid Automatically Explaining Machine Learning Predictions for Clinical Decision Support (Preprint)
Authors: Luo Gang
Published: May 2021

UNSTRUCTURED

Using machine learning predictive models for clinical decision support has great potential in improving patient outcomes and reducing health care costs. However, most machine learning models are black boxes that do not explain their predictions, thereby forming a barrier to clinical adoption. To overcome this barrier, an automated method was recently developed to provide rule-style explanations of any machine learning model’s predictions on tabular data and to suggest customized interventions. Each explanation delineates the association between a feature value pattern and an outcome value. Although the association and intervention information is useful, the user of the automated explaining function often requires more detailed information to better understand the patient’s situation and to aid in decision making. More specifically, consider a feature value in the explanation that is computed by an aggregation function on the raw data, such as the number of emergency department visits related to asthma that the patient had in the prior 12 months. The user often wants to rapidly drill through to see certain parts of the related raw data that produce the feature value. This task is frequently difficult and time-consuming because the few pieces of related raw data are submerged by many pieces of raw data of the patient that are unrelated to the feature value. To address this issue, this paper outlines an automated lineage tracing approach, which adds automated drill-through capability to the automated explaining function, and provides a roadmap for future research.
An Overview of the Treatment Options Used for the Management of COVID-19 in Pakistan: Retrospective Observational Study (Preprint)
Authors: Akhtar Hashaam , Akhtar Samar , Rahman Fazal-Ul , Afridi Maham , Khalid Sundas , Ali Sabahat , Akhtar Nasim , Khader Yousef S , Ahmad Hamaad , Khan Muhammad Mujeeb
Published: May 2021

BACKGROUND

Since the first reports of COVID-19 infection, the foremost requirement has been to identify a treatment regimen that not only fights the causative agent but also controls the associated complications of the infection. Due to the time-consuming process of drug discovery, physicians have used readily available drugs and therapies for treatment of infections to minimize the death toll.

OBJECTIVE

The aim of this study is to provide a snapshot analysis of the major drugs used in a cohort of 1562 Pakistani patients during the period from May to July 2020, when the first wave of COVID-19 peaked in Pakistan.

METHODS

A retrospective observational study was performed to provide an overview of the major drugs used in a cohort of 1562 patients with COVID-19 admitted to the four major tertiary-care hospitals in the Rawalpindi-Islamabad region of Pakistan during the peak of the first wave of COVID-19 in the country (May-July 2020).

RESULTS

Antibiotics were the most common choice out of all the therapies employed, and they were used as first line of treatment for COVID-19. Azithromycin was the most prescribed drug for treatment. No monthly trend was observed in the choice of antibiotics, and these drugs appeared to be a random but favored choice throughout the months of the study. It was also noted that even antibiotics used for multidrug resistant infections were prescribed irrespective of the severity or progression of the infection. The results of the analysis are alarming, as this approach may lead to antibiotic resistance and complications in immunocompromised patients with COVID-19. A total of 1562 patients (1064 male, 68.1%, and 498 female, 31.9%) with a mean age of 47.35 years (SD 17.03) were included in the study. The highest frequency of patient hospitalizations occurred in June (846/1562, 54.2%).

CONCLUSIONS

Guidelines for a targeted treatment regime are needed to control related complications and to limit the misuse of antibiotics in the management of COVID-19.
Respiratory and Cardiovascular Health Effects of e-Cigarette Substitution: Protocol for Two Living Systematic Reviews (Preprint)
Authors: O'Leary Renee , Qureshi Maria Ahmed , La Rosa Giusy Rita Maria , Vernooij Robin W M , Odimegwu Damian Chukwu , Bertino Gaetano , Polosa Riccardo
Published: May 2021

BACKGROUND

Despite the clear risks of tobacco use, millions of people continue to smoke. Electronic nicotine delivery systems (ENDS), commonly called e-cigarettes, have been proposed as a substitute for those who are unwilling or unable to quit. Current systematic and narrative reviews on the health effects of ENDS use, particularly respiratory and cardiovascular effects, have come to differing conclusions.

OBJECTIVE

We conducted two systematic reviews to critically assess and synthesize available human studies on the respiratory and cardiovascular health effects of ENDS substitution for people who smoke. The primary goal is to provide clinicians with evidence on the health effects of ENDS substitution to inform their treatment recommendations and plans. The twin goal of the reviews is to promote health literacy in ENDS users with facts on the health effects of ENDS.

METHODS

These two reviews will be living systematic reviews. The systematic reviews will be initiated through a baseline review. Studies will be evaluated using the JBI quality assessment tools and a checklist of biases drawn from the Centre for Evidence Based Medicine Catalogue of Bias. A narrative synthesis is planned because of the heterogeneity of data. A search for recently published studies will be conducted every 3 months, and an updated review will be published every 6 months for the duration of the project or possibly longer.

RESULTS

The baseline and updated reviews will be published in a peer-reviewed journal. The findings of the reviews will be reported in a white paper for clinicians and a fact sheet for people who use ENDS.

CONCLUSIONS

The substitution of ENDS for cigarettes is one way to potentially reduce the risks of smoking. Clinicians and their patients need to understand the potential benefits and possible risks of substituting ENDS for cigarettes. Our living systematic reviews seek to highlight the best and most up-to-date evidence in this highly contentious and fast-moving field of research.

CLINICALTRIAL

PROSPERO CRD42021239094; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=239094

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/29084
Assessing Trauma Management in Urban and Rural Populations in Norway: A National Register-Based Research Protocol (Preprint)
Authors: Nilsbakken Inger Marie Waal , Sollid Stephen , Wisborg Torben , Jeppesen Elisabeth
Published: May 2021

BACKGROUND

Time is considered an essential determinant in the initial care of trauma patients. In Norway, response time (ie, time from dispatch center call to ambulance arrival at scene) is a controversial national quality indicator. However, no national requirements for response times have been established. There is an ongoing debate regarding the optimal configuration of the Norwegian trauma system. The recent centralization of trauma services and closure of emergency hospitals have increased prehospital transport distances, predominantly for rural trauma patients. However, the impact of trauma system configuration on early trauma management in urban and rural areas is inadequately described.

OBJECTIVE

The project will assess injured patients’ initial pathways through the trauma system and explore differences between central and rural areas in a Norwegian trauma cohort. This field is unexplored at the national level, and existing evidence for an optimal organization of trauma care is still inconclusive regarding the impact of prehospital time.

METHODS

Three quantitative registry-based retrospective cohort studies are planned. The studies are based on data from the Norwegian Trauma Registry (NTR; studies 1, 2, and 3) and the local Emergency Medical Communications Center (study 2). All injured patients admitted to a Norwegian hospital and registered in the NTR in the period between January 1, 2015, and December 31, 2020, will be included in the analysis. Trauma registry data will be analyzed using descriptive and relevant statistical methods to compare prehospital time in rural and central areas, including regression analyses and adjusting for confounders.

RESULTS

The project received funding in fall 2020 and was approved by the Oslo University Hospital data protection officer, case number 18/02592. Registry data including approximately 40,000 trauma patients will be extracted during the first quarter of 2022, and analysis will begin immediately thereafter. Results are expected to be ready for publication from the third quarter of 2022.

CONCLUSIONS

Findings from the study will contribute to new knowledge regarding existing quality indicators and with an increasing centralization of hospitals and residents, the study will contribute to further development of the Norwegian trauma system. A high generalizability to other trauma systems is expected, given the similarities between demographical changes and trauma systems in many high-income countries.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/30656
Preventive Digital Mental Health for Children in Primary Schools: Acceptability and Feasibility Study (Preprint)
Authors: Davies Sian M , Jardine Jenni , Gutridge Kerry , Bernard Zara , Park Stephen , Dawson Tom , Abel Kathryn M , Whelan Pauline
Published: May 2021

BACKGROUND

The incidence of mental health problems in children and adolescents in the United Kingdom has significantly increased in recent years, and more people are in contact with mental health services in Greater Manchester than in other parts of the country. Children and young people spend most of their time at school and with teachers. Therefore, schools and other educational settings may be ideal environments in which to identify those experiencing or those at the risk of developing psychological symptoms and provide timely support for children most at risk of mental health or related problems.

OBJECTIVE

This study aims to test the feasibility of embedding a low-cost, scalable, and innovative digital mental health intervention in schools in the Greater Manchester area.

METHODS

Two components of a 6-week digital intervention were implemented in a primary school in Greater Manchester: Lexplore, a reading assessment using eye-tracking technology to assess reading ability and detect early atypicality, and Lincus, a digital support and well-being monitoring platform.

RESULTS

Of the 115 children approached, 34 (29.6%) consented and took part; of these 34 children, all 34 (100%) completed the baseline Lexplore assessment, and 30 (88%) completed the follow-up. In addition, most children were classified by Lincus as regular (≥1 per week) survey users. Overall, the teaching staff and children found both components of the digital intervention engaging, usable, feasible, and acceptable. Despite the widespread enthusiasm and recognition of the potential added value from staff, we met significant implementation barriers.

CONCLUSIONS

This study explored the acceptability and feasibility of a digital mental health intervention for schoolchildren. Further work is needed to evaluate the effectiveness of the digital intervention and to understand whether the assessment of reading atypicality using Lexplore can identify those who require additional help and whether they can also be supported by Lincus. This study provides high-quality pilot data and highlights the potential benefits of implementing digital assessment and mental health support tools in a primary school setting.

CLINICALTRIAL
Implementation of principle for responsible investment in distribution of bank credits on infrastructure projects
Authors: Andika Nadia , Abubakar Lastuti , Handayani Tri
Published: May 2021

This research aims to discuss a large amount of credit lending is in line with the potential risk to the environment which is also caused by Toll Road construction activities. Therefore, Banks, Development, and the environment cannot be separated from one to another mainly because the Bank is responsible for taking preventive steps, other than implementing the substance of 5C principles, Bank is also obliged to implement several principles mentioned in POJK 51/2017, one of which is Principle for Responsible Investment. However, there are still no standards for the implementation of these principles or any strict penalties for Banks that are not applying the principle. This creates legal uncertainty, as it causes a potential risk that the Bank indirectly has not any obligation to implement it, yet only as a form of recommendation, whereas on the other hand, infrastructure development still damages the environment as it happened at the construction of Trans Sumatra Toll Road. In contrast to what Indonesia has done, Australia uses a variety of strategies to implement the Principle for Responsible Investment. In line with this issue, this research is using the normative legal research method where it is expected to provide different perspectives that will be useful for maximizing the realization of the Principles for Responsible Investment as part of Sustainable Finance in credit lending practices for Infrastructure development projects. Thus, it aims to make more detailed legal reforms, primarily regarding the standardization and sanctions of Principles for Responsible Investment including its derivative regulations hence that a sustainable environment will be realized.
Tanggungjawab Perusahaan Angkutan Terhadap Kerugian yang Ditimbulkan Akibat Kelalaian Pengemudi Selama Kegiatan Penyelenggaraan Pengangkutan
Authors: Sancaya I Wayan Werasmana , Putra I Made Aditya Mantara
Published: May 2021

Secara fakta dapat diamati bahwa pengemudi angkutan tidak jarang melakukan tindakan yang diakibatkan kesengajaaan ataupun kelalaian yang berakibat pada kerugian bagi orang lain, yang dalam hal ini baik kerugian materiil ataupun kerugian immateriil. Hal tersebut dapat digambarkan seperti misalnya tindakan pengemudi yang sedang mengendarai kendaraannya secara tidak wajar dalam arti pada saat menjalankan tugas pengemudi sedang dalam keadaan tidak fit, lelah atapun dalam pengaruh alkohol atau obat terlarang yang tentu sangat berpengaruh terhadap kemampuannya untuk mengemudi kendaraan, sehingga terjadi kecelakaan dan menimbulkan kerugian bagi orang lain. Berdasarkan uraian tersebut maka peneliti merasa perlu untuk meneliti tingkat dan bentuk tanggungjawab perusahaan transportasi angkutan barang. Jenis penelitian yang dipergunakan dalam penelitian ini adalah jenis penelitian hukum empiris. Hasil daripada penelitian yaitu mengenai pengaturan pertanggungjawaban perusahaan angkutan dalam hal terjadi kerugian yang diakibatkan pengemudi selama kegiatan penyelenggaraan pengangkutan pada Kantor Pos Cabang Kamboja Denpasar dan PT. Maharani Prema Sakti Denpasar mengacu pada Undang-Undang No 22 Tahun 2009 Tentang Lalu Lintas Angkutan Jalan, yang dituangkan juga dalam perjanjian kontrak kerja antara perusahaan pengangkutan dengan pengemudi. Bentuk pertanggungjawaban perusahaan yakni Kantor Pos Cabang Kamboja Denpasar terhadap pengemudi, perusahaan sebelum memperkerjakan pengemudi sudah mengikutsertakan pengemudi tersebut dengan Asuransi. Namun apabila biaya asuransi masih kurang mencukupi untuk mem-back up pembiayaan pengemudi yang mengalami kecelakaan tersebut maka kekurangan biaya akan ditanggung oleh perusahaan. Sedangkan bentuk pertanggungjawaban pada perusahaan PT. Maharani Prema Sakti Denpasar yakni bertanggungjawab sesuai dengan isi daripada perjanjian kontrak kerja yang menyatakan tanggungjawabnya dalam nominal yang sudah ditentukan.
CHANGE ORDER DAN RISIKO CHANGE ORDER PADA PROYEK JALAN DI JAWA BARAT
Authors: Mega Waty  , Hendrik Sulistio
Published: May 2021

Change Order merupakan perubahan yang terjadi pada proyek konstruksi dan tidak bisa dihindari. Analisis change order pada 10 Proyek pembangunan jalan Jawa Barat meneliti bagaimana penyebab change order bervariasi antara proyek peningkatan versus proyek pemeliharaan, dan jenis konstruksi (mis. pekerjaan aspal, drainase, struktur, dan pelebaran bahu jalan dan perkerasan berbutir, pengembalian kondisi dan pekerjaan minor dan pekerjaan harian). Penelitian ini juga meneliti risiko yang ditimbulkan oleh change order dengan mengukur frekuensi dan rata-rata persentase perubahan biaya proyek untuk berbagai jenis change order. Metodologi penelitian dangan mencari data riil proyek pembangunan jalan dari tahun 2014-2018. Hasilnya adalah penyebab utama change order secara konsisten adalah penghilangan kontrak, peningkatan yang disebabkan oleh pemilik, dan membengkaknya item kontrak dan kelalaian kontrak. Risiko  change order pada tertinggi pada pekerjaan: Campuran Aspal Panas, Lapis Pondasi Atas Kelas S, Laston Lapis Aus, Pasangan batu, Lapis Pondasi Atas Kelas B, Perkerasan Beton Semen, Beton mutu rendah f'c 15 MPa, Pasangan Batu dengan Mortar, Timbunan Pilihan, Marka Jalan Termoplastik.
Value cocreation behavior of users in an online social question-andanswer community
Authors: Yang Xuecheng , Sui Yue
Published: May 2021

Online social question-and-answer (Q&A) communities provide a platform for people to acquire high-quality knowledge and have become an important mode through which users can cocreate value. We applied self-determination theory and the stimulus–organism–response framework
to develop a model of how platform characteristics influence users' self-determination in virtual communities, thereby influencing their value cocreation behavior. Data obtained from a survey of 385 users in an online social Q&A community show that personalized recommendations, social
interaction, and information richness each had a positive impact on user selfcompetence, self-autonomy, and self-relatedness, which subsequently affected their knowledge-sharing and knowledge-integration behaviors. Moreover, self-determination had a mediating effect in the relationship between
platform characteristics and users' knowledge-sharing and knowledge-integration behaviors. Our findings provide evidence for how to promote value cocreation in a social Q&A community.
Seasonal variation in elemental composition of certain red algae from Southeast coast of India
Authors:   Department of Botany, Periyar Govt. Arts College, Cuddalore-607001 (Annamalai University), Tamil Nadu, India, Murugaiyan K.
Published: May 2021

Three species of red algae belonging to the class Rhodophyceae viz. Amphiroa fragilissima, Centroceras clavulatum and Gracilaria canaliculata were collected from seven localities in the southeast coast of India. The collected red algae were analysed for elemental composition (Al, B, Cd, Co, Cr, Cu, Fe, Mg, Mn, Ni, Fb, Zn) using inductively coupled plasma atomic emission spectroscopy (ICP - AES) from May 2018 to April 2019 at three months interval. The seasonal variation in the elemental composition of the three red algae species showed that most of the minerals were found to accumulate during the summer season followed by pre-monsoon season. This could perhaps be due to the ambient concentration of these minerals were high during these seasons; thereby facilitating their uptake by seaweeds. The accumulation factor of certain irons by the algae were also discussed in this paper.
Outpatient Percutaneous Liver Biopsy is a Low-risk Procedure and has Steatosis as a New Indication Trend
Authors: Cunha Marlone , Torres Luiza , Franson Mariana , Secundo Tirzah , Moreira Marina , Yamanaka Ademar , Monici Leonardo , Costa Larissa Eloy da , Mazo Daniel , Sevá-Pereira Tiago
Published: May 2021

BACKGROUND. Histological evaluation has a crucial role in diagnosing
hepatic diseases and percutaneous liver biopsy (PLB) is widely chosen
for this purpose. We aim to describe its indications, the rate and
severity of adverse events (AEs) in an outpatient and ultrasound
(US)-guided setting over 5 years. METHODS. This observational,
single-center, and retrospective study included patients submitted to
PLB between 2015 and 2019. We collected age, gender, coagulation tests,
comorbidities, and number of needle passes. The association between the
variables and outcomes (pain, mild and serious AEs, hospital admission,
surgical treatment, and death) was evaluated using the generalized
estimating equations method. RESULTS. We analyzed 532 biopsies in 524
patients (55.3% male) aged 49y (13–74y). Almost 39% had
cardiovascular comorbidities and 18% had overweight/obesity. Hepatitis
C virus (HCV) chronic infection was the major indication for PLB (47%),
followed by autoimmune hepatitis/cholestasis (12.6%), and metabolic
dysfunction-associated fatty liver disease (MAFLD) (12.1%). The number
of HCV-related biopsies had a remarkable reduction, while MAFLD-related
procedures have progressively raised over time. Around 54% of the
patients reported pain, which was significantly associated with the
female gender (p=0.0143). Serious AEs occurred in 11 patients (2.1%);
hospital admission was necessary in 10 cases (1.9%), but no patient
required surgical approach and there were no deaths. No significant
association was found between the occurrence of AEs and the studied
variables (clinical, laboratory, and number of needle passes).
CONCLUSION. Real-time US-guided PLB is safe to perform in an outpatient
setting and its indications have notably undergone a transition from HCV
to MAFLD over the years. New strategies to prevent biopsy-related pain
are still needed, especially for females.
Distributional effects of foreign versus domestic investment: Evidence from post-communist EU member states
Authors: Josifidis Kosta , Supic Novica , Bodor Sladjana
Published: May 2021

The paper provides insight into the relationship between foreign and domestic
investment, and its effect on income distribution in the post-communist EU
member states. The analysis is conducted using the general method of moment
(GMM) estimator on panel data of the 10 Central and Eastern European (CEE)
new member states from 1993-2017. The results reveal that a greater level of
foreign direct investments (FDI) contributed to eliminating the negative
effects of domestic investment on income distribution, particularly mass
layoffs and the transfer of wealth into the hands of a small economic and
political elite. It leads to the conclusion that FDI has played a
significant role in reducing income inequality and rebuilding the middle
class in the post-communist EU member states.
Erratum to: Shocks, financial constraints and households’ consumption amid the great recession
Authors: Editorial E
Published: May 2021

After publication of the original article, it came to the authors? attention that during the editing process a mathematical operator is missing in the text on pages 5 and 12.

 Link to the corrected article 10.2298/PAN2101001A
Hemodialysis-Related Glycemic Disarray Proven by Continuous Glucose Monitoring; Glycemic Markers and Hypoglycemia
Authors: Hayashi Akinori , Shimizu Naoya , Suzuki Agena , Matoba Kenta , Momozono Akari , Masaki Tsuguto , Ogawa Akifumi , Moriguchi Ibuki , Takano Koji , Kobayashi Naoyuki , Shichiri Masayoshi
Published: May 2021

OBJECTIVE

There is a high risk of asymptomatic hypoglycemia associated with hemodialysis (HD) using glucose-free dialysate; therefore, the inclusion of glucose in the dialysate is believed to prevent intradialytic hypoglycemia. However, the exact glycemic fluctuation profiles and frequency of asymptomatic hypoglycemia using dialysates containing >100 mg/dL glucose have not been determined.

RESEARCH DESIGN AND METHODS

We evaluated the glycemic profiles of 98 patients, 68 of whom were men, with type 2 diabetes undergoing HD (HbA1c 6.4 ± 1.2%; glycated albumin 20.8 ± 6.8%) with a dialysate containing 100, 125, or 150 mg/dL glucose using continuous glucose monitoring.

RESULTS

Sensor glucose level (SGL) showed a sustained decrease during HD, irrespective of the dialysate glucose concentration, and reached a nadir that was lower than the dialysate glucose concentration in 49 participants (50%). Twenty-one participants (21%) presented with HD-related hypoglycemia, defined by an SGL <70 mg/dL during HD and/or between the end of HD and their next meal. All these hypoglycemic episodes were asymptomatic. Measures of glycemic variability calculated using the SGL data (SD, coefficient of variation, and range of SGL) were higher and time below range (<70 mg/dL) was lower in participants who experienced HD-related hypoglycemia than in those who did not, whereas time in range between 70 and 180 mg/dL, time above range (>180 mg/dL), HbA1c, and glycated albumin of the two groups were similar.

CONCLUSIONS

Despite the use of dialysate containing 100–150 mg/dL glucose, patients with diabetes undergoing HD experienced HD-related hypoglycemia unawareness frequently. SGL may fall well below the dialysate glucose concentration toward the end of HD.
Exposing the intersections of health, society, and economics during a pandemic – perspectives from Cambodia
Authors: Water Tineke
Published: May 2021

N/A
To exit or not to exit: Evaluating a case management pathway in a Global South context to decrease service dependency
Authors: Henley Lee
Published: May 2021

An evaluation was undertaken of a case management pathway for a child protection organization in Cambodia to decrease service dependency. Save the Children’s ‘Steps to Protect’ was used as an evaluation framework to identify how the organization met the criteria for the core components of case management. These included identification and initial screening, case planning, implementation, and case review, and the findings show that a well-defined, staged process for case management actively reduces service dependency. The recommendations are that a staged case management pathway should be developed in child protection services as an approach for reducing service dependency.
On I-statistically limit points and I-statistically cluster points of sequences of fuzzy numbers
Authors: Tripathy Binod Chandra , Debnath Shyamal , Rakshit Debjani
Published: May 2021

The main aim of this paper is to introduce I-st limit points and I-st cluster points of a sequence of fuzzy numbers and also study some of its basic properties. Conditions for a I-st limit point of a I-st cluster point are investigated.
PEMBERDAYAAN MASYARAKAT MELALUI PELATIHAN PENDAMPINGAN PENYUSUNAN BUKU PROFIL DESA SINGOYUDAN, MIRIT, KEBUMEN BERBASIS SISTEM INFORMASI DAN KOMUNIKASI ONLINE (SISKON)
Authors: Sakir Sakir , Astuti Laras , Ishak Aswad
Published: May 2021

Kegiatan pengabdian masyarakat dilaksanakan dengan dua kegiatan utama yaitu Pembuatan Buku Profil Desa dan Penguatan Sistem Informasi Desa (SID) di Desa Singoyudan, Kecamatan Mirit, Kabupaten Kebumen. Potensi yang dimiliki oleh desa harus dapat menjadi jati diri pengembangan kemajuan desa. Metode yang digunakan adalah dengan melakukan pendampingan dan melibatkan mahasiswa Universitas Muhammadiyah Yogyakarta untuk secara langsung terjun ke lapangan dan mengembangkan/menyusun profil dusun dan pembuatan website serta pelatihan untuk mewujudkan SDM yang handal. Output yang dihasilkan dari pengabdian masyarakat ini antara lain: Pertama, Desa Singoyudan telah memiliki buku profil desa dengan edisi terbaru dan dengan penambahan informasi-informasi yang diperlukan. Kedua, Desa Singoyudan memiliki website dan media sosial aktif yang berisi informasi-informasi desa dan dusun. Pengembangan yang perlu dilakukan setelah program ini antara lain pembaharuan profil dusun yang up-to-date serta pemanfaatan media sosial dalam pemberian pelayanan selain website yang telah dibuat.
PENINGKATAN KREATIVITAS MASYARAKAT MELALUI PENGOLAHAN JAGUNG DI DESA KUMPULREJO KECAMATAN PARENGAN KABUPATEN TUBAN
Authors: Setyaningrum Dyah , Septiani Ita Yunira
Published: May 2021

Program pengabdian masyarakat ini dilatarbelakangi dengan melimpahnya hasil pertanian musim kemarau yang ada di Desa Kumpulrejo, Kecamatan Parengan, Kabupaten Tuban. Dengan komoditas utamanya adalah jagung. Permasalahan dan kendala utama yang dihadapi para petani jagung di daerah Desa Kumpulrejo adalah belum adanya diversifikasi produk olahan jagung yang berdaya jual tinggi. Kondisi ini dikarenakan masih rendahnya pengetahuan dan minimnya informasi tentang nilai gizi jagung, tampilan produk pangan dari jagung yang kurang menarik, dan adanya anggapan bahwa jagung hanya dikonsumsi oleh masyarakat berekonomi lemah. Solusi yang dapat dilakukan adalah dengan membuat olahan jagung menjadi produk makanan yang kreatif dan inovatif, misalnya puding jagung susu keju (jasuke). Pengabdian dilakukan dengan dengan cara sosialisasi dan demo pembuatan produk secara langsung. Target utamanya adalah ibu – ibu dan remaja putri. Kegiatan ini berjalan dengan lancar dan sukses. Hal ini dibuktikan dengan antusias warga dalam mengikuti kegiatan serta adanya warga yang melanjutkan peluang bisnis baru ini. Hasil yang diperoleh dari program pengabdian masyarakat ini adalah terciptanya pemahaman masyarakat akan pentingnya berwirausaha, meningkatkan keterampilan masyarakat dalam mengolah berbagai produk makanan dengan memperhatikan GMP (Good Manufacturing Practices), menciptakan peluang usaha bagi masyarakat, serta meningkatkan pendapatan masyarakat
Una mirada sobre el presente y el futuro de la actividad profesional desarrollada por el auditor externo de estados contables
Authors: Slosse Carlos Alberto
Published: May 2021

El presente ensayo pretende ser una discusión argumentativa sobre distintos aspectos de la cruda, actual realidad con la que se encuentra el contador público cuando se dedica, en nuestro país, a realizar auditorías externas de estados contables.

También se realiza una mirada hacia el futuro, al abordar cuestiones que podrían mejorarse y que, de concretarse, contribuirán a prestigiar nuestra profesión. Debe tenerse en cuenta que el carácter “público” de nuestro título profesional se refiere a la fe, pública, que terceros depositan en un juego de estados contables, preparados por la  administración de una empresa y que están acompañados de un informe o dictamen de  un contador público.
Predictive control of a cascade of biochemical reactors
Authors: Mojto Martin , Horváthová Michaela , Kiš Karol , Furka Matúš , Bakošová Monika
Published: May 2021

Rapid growth of the human population has led to various problems, such as massive overload of wastewater treatment plants. Therefore, optimal control of these plants is a relevant subject. This contribution analyses control of a cascade of ten biochemical reactors using simulation results with the aim to design optimal and predictive control strategies and to compare the achieved control performance. The plant represents a complicated process with many variables involved in the model structure, reduced to the single-input and single-output system. The first implemented approach is linear offset-free model predictive control which provides the optimal input trajectory minimising a quadratic cost function. The second control strategy is robust model predictive control with similar features as model predictive control but including the uncertainty of the process. The final approach is generalised predictive control, mostly used in the industry because of its simple structure and sufficiently good control performance. All considered predictive controllers provide satisfactory control performance and remove the steady-state control error despite the constrained control inputs.
The Letter Exchange on the Romanian Front during the First World War
Authors: Bichicean Gheorghe , Mardale Florin Emil
Published: May 2021

Letters, unusual postcards, censored, illustrate the mood on the front, conveyed by two participants to the world’s first conflagration. The first letter, dated October 26, 1916, belongs to Lieutenant D. Stoica, commander of the Second Section Telegraph. A simple letter, which expresses much optimism, sent to his wife Ionela, two months after Romania’s entry into the national reunification war, accompanied by his portrait. The second letter, dated 1918, is more intense in terms of experiences, sent to a lady named Marie Ionescu, by a Romanian wounded during the battles. The letter, from the stamp that only marks the year 1918, could be dated approximately after November this year. The militant was in convalescence in a camp hospital, waiting to be resent on the front.