bluuebunny/crossref_metadata_2025 huggingface dataset:
Hsa-LINC02418/mmu-4930573I07Rik regulated by METTL3 dictates anti-PD-L1 immunotherapeutic efficacy via enhancement of Trim21-mediated PD-L1 ubiquitination
Authors: Sun Zhijia , Mai Haixing , Xue Chunyuan , Fan Zhongyi , Li Jiangbo , Chen Hairui , Huo Nan , Kang Xiaofeng , Tang Chuanhao , Fang Liaoxin , Zhao Hui , Han Yuchen , Sun Chao , Peng Huanyan , Du Yimeng , Yang Jing , Du Nan , Xu Xiaojie
Published: December 2023

Background

Limited response to programmed death ligand-1 (PD-L1)/programmed death 1 (PD-1) immunotherapy is a major hindrance of checkpoint immunotherapy in non-small cell lung cancer (NSCLC). The abundance of PD-L1 on the tumor cell surface is crucial for the responsiveness of PD-1/PD-L1 immunotherapy. However, the negative control of PD-L1 expression and the physiological significance of the PD-L1 inhibition in NSCLC immunotherapy remain obscure.

Methods

Bioinformatics analysis was performed to profile and investigate the long non-coding RNAs that negatively correlated with PD-L1 expression and positively correlated with CD8+T cell infiltration in NSCLC. Immunofluorescence,in vitroPD-1 binding assay, T cell-induced apoptosis assays andin vivosyngeneic mouse models were used to investigate the functional roles of LINC02418 and mmu-4930573I07Rik in regulating anti-PD-L1 therapeutic efficacy in NSCLC. The molecular mechanism of LINC02418-enhanced PD-L1 downregulation was explored by immunoprecipitation, RNA immunoprecipitation (RIP), and ubiquitination assays. RIP, luciferase reporter, and messenger RNA degradation assays were used to investigate the m6A modification of LINC02418 or mmu-4930573I07Rik expression. Bioinformatics analysis and immunohistochemistry (IHC) verification were performed to determine the significance of LINC02418, PD-L1 expression and CD8+T cell infiltration.

Results

LINC02418 is a negative regulator of PD-L1 expression that positively correlated with CD8+T cell infiltration, predicting favorable clinical outcomes for patients with NSCLC. LINC02418 downregulates PD-L1 expression by enhancing PD-L1 ubiquitination mediated by E3 ligase Trim21. Both hsa-LINC02418 and mmu-4930573I07Rik (its homologous RNA in mice) regulate PD-L1 therapeutic efficacy in NSCLC via Trim21, inducing T cell-induced apoptosisin vitroandin vivo. Furthermore, METTL3 inhibition via N6-methyladenosine (m6A) modification mediated by YTHDF2 reader upregulates hsa-LINC02418 and mmu-4930573I07Rik. In patients with NSCLC, LINC02418 expression is inversely correlated with PD-L1 expression and positively correlated with CD8+T infiltration.

Conclusion

LINC02418 functions as a negative regulator of PD-L1 expression in NSCLC cells by promoting the degradation of PD-L1 through the ubiquitin-proteasome pathway. The expression of LINC02418 is regulated by METTL3/YTHDF2-mediated m6A modification. This study illuminates the underlying mechanisms of PD-L1 negative regulation and presents a promising target for improving the effectiveness of anti-PD-L1 therapy in NSCLC.
Hybrid cascade failures in supply chain networks: Robustness, node protection and recovery strategies
Authors: Li Dandan , Zhou Kai , Han Dun
Published: December 2023

This study investigates the influence of mixed cascade failures on the resilience of manufacturing enterprise supply chain networks, which are susceptible to disruptions from upstream and downstream enterprises due to external uncertainties. We propose a single-layer directed network model to examine mixed cascade failures and analyze the effectiveness of protection and recovery strategies for improving network resilience through extensive simulation experiments. The numerical analysis yields the following key findings: (i) Under targeted attacks, the Erdős–Rényi (ER) network exhibits marginally enhanced robustness, whereas the Barabási–Albert (BA) network proves to be more resilient against random attacks. (ii) Effectively mitigating failure risk and reducing the likelihood of failure can be accomplished by increasing the upper load capacity limit and decreasing the lower load capacity limit for manufacturing firms. Furthermore, a comprehensive approach to protection and recovery measures strengthens the stability of supply chain networks in the face of external risks. (iii) Constraints, such as epidemic control measures and infrastructure damage, may impede the recovery process of manufacturing firms’ supply chains when addressing external uncertainties.
On pretzel links which are concordant to the trivial link
Authors: Nakanishi Yasutaka , Shibuya Tetsuo , Tsukamoto Tatsuya
Published: December 2023

In this paper, we study conditions for [Formula: see text]-component pretzel links to be concordant to the trivial link.
IMPROVEMENT OF FORMABILITY AND SURFACE FINISH OF CUPRO–NICKEL (70/30) ALLOY DURING SINGLE POINT INCREMENTAL FORMING PROCESS USING CHROME STEEL LASER ABLATED BALL
Authors: ARUN PRASAD M. , SATHIYA NARAYANAN C. , VARATHARAJULU M. , PANDIVELAN C.
Published: December 2023

Cupro–nickel alloy of 70/30 grade was experimented for its formability by SPIF tests, namely straight groove test and wall angle test using a ball attached tool, to emphasize the concern on formability and surface roughness. Two different types of ball were used, one ball was used in polished form and another one was surface-textured using Nd-Yag laser. The cupro–nickel alloy has excellent corrosion resistance and popularly used in marine environments. In this research, an attempt has been made to study the formability when using Chrome steel laser ablated ball. The results concluded that Chrome steel laser ablated ball with oil as lubrication has avoided the occurrence galling and at the same time improved the formability. When experimenting with chrome steel polished ball, the tool and sheet contact is high and the lubricating oil will be less and it is causing the sheet to get heated. The dimples on the ball’s surface made by the laser retain more lubricating oil and thereby decreasing the friction which eventually leads to the delayed fracture. It is found that the formability was increased by 16% in straight groove test, 4.8% for wall angle test and surface roughness values were decreased by 1.4%.
An Energy Transfer-Based Bifurcation Detection Method for Nonlinear Rotating Systems: Enables Accurate Capture of Period-Doubling Bifurcation and Instability
Authors: Zhao Runchao , Xu Yeyin , Li Zhitong , Chen Zengtao , Xu Zili , Chen Zhaobo , Jiao Yinghou
Published: December 2023

Rotor systems are widely used in industrial power generation and propulsion. Once the nonlinear contact stiffness and oil film force are taken into account, the dynamics and stability of rotor systems become quite complex, often accompanied by super-harmonic and chaotic motions. Furthermore, conventional methods face limitations in real-time detection of the bifurcations and complex nonlinear motions. This research investigates the bifurcations and stability induced by nonlinear factors in a rotor-bearing system from an energy perspective. Dynamic equations of a rotor-bearing system considering cubic term stiffness are established, the steady responses are obtained by the fourth-order Runge–Kutta method. The relationship between the bifurcations and energy transfers is analyzed numerically, the proposed stability criterion is validated by comparing the Lyapunov exponents. The bistable phenomenon of period-3[Formula: see text] ([Formula: see text]) motion is discussed in terms of numerical results and experiments which corresponds to the asymmetric jumps of the generalized energy. It is found that bifurcations and unstable motions of the nonlinear system can be captured accurately by detecting the energy transfers, the proposed generalized energy curve exhibits more detailed information than the conventional speed-up curve. These findings provide a new perspective on studying bifurcations and stability of rotating systems, which can be further applied in the condition monitoring, stability prediction as well as the design of nonlinear energy sink, representing significant progress in converting theory into engineering applications for rotor systems.
A 2D-CNN-Based Two-Stage Structural Damage Localization and Quantification Technique Using Time Domain Vibration Data
Authors: Das Tanmay , Guchhait Shyamal
Published: December 2023

The conventional approaches for detecting structural degradation are time-consuming, labor-intensive, and costly. The physical monitoring of the structure also poses risks to the health and safety of supervisors. Therefore, damage estimation of any structure using artificial intelligence (AI), more specifically deep learning (DL), is becoming more significant in civil infrastructure. In the presented research article, an efficient two-stage damage detection method is proposed for structural damage detection (SDD) from time domain vibration signals. The proposed method utilizes two-dimensional convolutional neural network (2D-CNN) architecture as a DL algorithm for damage detection. Here, a computer-aided damage detection method for steel beam and frame-type structures is developed using 2D-CNN algorithm in the Google Colab platform. The effectiveness of the proposed method is first verified, and it provides more than 90% accuracy for identifying the damage location and severity of a cantilever beam for single- and multi-damage scenarios from numerically simulated noisy displacement data. The algorithm is also experimentally validated through the raw acceleration data of damaged steel frame joints collected from the Qatar University Grandstand simulator (QUGS). The proposed 2D-CNN algorithm performs better than other DL algorithms by achieving 100% accuracy within 10 epochs for damage detection of steel frames using QUGS data. It demonstrates significant potential for detecting damage location and quantifying damages for single- and multi-damage scenarios using noise-free and noisy datasets. The primary contribution of this study resides in the implementation of two-stage damage detection algorithm utilizing 2D-CNN with time domain vibration response for multiclass damage identification and quantification.
Technology Takes the Wheel: Unveiling the Drivers of Car Dashcam Adoption
Authors: Ashrafi Dewan Mehrab
Published: December 2023

This study aimed to investigate and provide insight into the drivers and motivations behind users’ intentions for using car dashcams. The study utilized a purposive sampling technique with a sample size of 225 and obtained responses through a structured questionnaire. Partial least squares structural equation modeling (PLS-SEM) was performed to verify the proposed hypotheses. The findings demonstrated that the perceived quality of the system, the quality of the information, and the quality of the interaction positively influenced the perceived ease of use and usefulness of using car dashcams. Attitude and behavioral intention were affected by perceived ease of use and usefulness, while perceived usefulness had no influence on intention to use car dashcams. While hedonic motivation and price value impacted behavioral intention, social intention did not affect it. Attitude was found to fully mediate the path between perceived usefulness and behavioral intention. The outcomes of the study incorporate a considerable amount of knowledge into the adoption behavior of telematics literature by integrating prevalent technology adoption models into a unified model: The information system success model (ISS), technology acceptance model (TAM), and unified theory of acceptance and use of technology 2 (UTAUT2). The findings provide valuable insights for marketers, the dash cam industry, and policymakers to enhance their understanding of the critical factors affecting the adoption of car dashcams, which can assist in customizing their marketing campaigns and policies to encourage the usage of dashcams, leading to improved road safety and safe driving behavior.
The Realities of Evaluating Educational Technology in School Settings
Authors: Venn-Wycherley Megan , Kharrufa Ahmed , Lechelt Susan , Nicholson Rebecca , Howland Kate , Almjally Abrar , Trory Anthony , Sarangapani Vidya
Published: December 2023

HCI researchers are increasingly interested in the evaluation of educational technologies in context, yet acknowledge that challenges remain regarding the logistical, material and methodological constraints of this approach to research [
18
,
53
].

Through the analysis of the authors’ contributed thematic research vignettes, the following article exposes the practical realities of evaluating educational technologies in school settings. This includes insights into the planning stages of evaluation, the relationship between the researcher and the school environment, and the impact of the school context on the data collection process.

We conclude by providing an orientation for the design of HCI educational technology research undertaken in school contexts, providing guidance such as considering the role of modular research design, clarifying goals and expectations with school partners, and reporting researcher positionality.
Home-Based Dialysis: A Primer for the Internist
Authors: Rope Robert , Ryan Eric , Weinhandl Eric D. , Abra Graham E.
Published: December 2023

Home-based dialysis modalities offer both clinical and practical advantages to patients. The use of the home-based modalities, peritoneal dialysis and home hemodialysis, has been increasing over the past decade after a long period of decline. Given the increasing frequency of use of these types of dialysis, it is important for clinicians to be familiar with how these types of dialysis are performed and key clinical aspects of care related to their use in patients with end-stage kidney disease.
Cardiovascular dysfunction induced by combined exposure to nicotine inhalation and high-fat diet
Authors: Whitehead Anna K. , Li Zhen , LaPenna Kyle B. , Abbes Nour , Sharp Thomas E. , Lefer David J. , Lazartigues Eric , Yue Xinping
Published: December 2023

Nicotine product usage and high-fat diet consumption are two modifiable risk factors for cardiovascular diseases. Here, we demonstrate that in mice, combined exposure to inhaled nicotine and high-fat diet results in unique cardiovascular consequences compared with either treatment alone, including left ventricular diastolic dysfunction, dysregulation of blood pressure, autonomic dysfunction, and greater impairment of endothelium-dependent vasorelaxation. These findings indicate that individuals who consume both nicotine products and high-fat diet have distinctive cardiovascular risks.
Arterial stiffness mediates the association between age and processing speed at low levels of microvascular function in humans across the adult lifespan
Authors: Ransom Kyndall V. , Traylor Miranda K. , Batman Genevieve B. , Mulekar Madhuri S. , Hill Benjamin D. , Nelson Amy R. , Keller Joshua L.
Published: December 2023

Arterial stiffness partially mediates the association between age and processing speed in the presence of low microvascular function, as demarcated by maximum tissue oxygenation following ischemia. Central and peripheral pulse pressure remained associated with processing speed even after controlling for age. Our findings were derived from a sample that was determined to be cognitively healthy, which highlights the potential for these outcomes to be considered during trials aimed at the prevention of cognitive decline.
Precipitation of Polypropylene and Polyethylene Terephthalate Powders Using Green Solvents via Temperature and Antisolvent-Induced Phase Separation
Authors: Hanschmann Benedikt
Published: December 2023

Polymer dissolution and precipitation are two common processes for the production of polymer powders, especially for cases where usual means of comminution are not applicable. I investigated six dissolution–precipitation processes based on high-boiling sustainable green organic solvents and antisolvents for the polypropylene and polyethylene terephthalate with respect to apparent particle morphology for a closed loop production scheme. Of the investigated processes two are considered antisolvent-induced precipitations whereas the other four can be considered temperature induced. The applied solvents included p-cymene, dibutoxymethane, ethylbenzoate, γ-valerolactone, ethanol, and hexanol. All processes yielded powders consisting of agglomerated primary particles at a powder dry substance of less than 25% by weight. The produced powders consist in all cases of agglomerates of smaller primary particles.
A Critical Review of Social Exclusion and Inclusion among Immigrant and Refugee Women
Authors: Crawford J. , Kapisavanhu N. , Moore J. , Crawford C. , Lundy T.
Published: December 2023

International and global migration has risen over the last 50 years, and this trend is not expected to change. Immigrants and refugees make sociocultural and economic contributions to settlement states; however, this does not always mean that they feel included or welcomed. Social exclusion as a determinant of health reflects the social inequalities of some groups in a population over others. Immigrants and refugees are excluded from participating in social, economic, civic, and political domains within Western settlement countries; women experience greater social exclusion because of intersecting social identities and the interplay between sociostructural systems that create inequalities within host societies. To explore this phenomenon more fully, we conducted a critical review of how social exclusion and inclusion are experienced by women settling in Western contexts and the factors that impact daily life and health. Intersectionality was the lens with which we situated, examined, and analyzed the findings of the critical review to inform the development of a conceptual model. A five-stage process was used to comprehensively review the literature using six databases. Sixty papers were included in the review. The conceptual model highlighted two overarching themes that were further distinguished by micro-, meso-, and macro-level factors of exclusion and inclusion. The first theme considers the causes and outcomes of social exclusion represented as social determinants in the context of settlement and includes social environment, social supports, language ability, discrimination and racism, settlement and identity, income and employment, education and professional credentials, institutions, and government services. The second theme of social inclusionary processes consisted of social capital, social and civic participation, empowerment, and policies and settlement programs. The conceptual model advances knowledge of potential improvements required in formal settlement programs and the importance of informal programs that collectively may enhance inclusion for immigrant/refugee women and their families in Western contexts.
Gamma Irradiation of Plukenetia volubilis L. Seeds Promotes Several Changes during Its Germination and Vegetative Growth
Authors: Corazon-Guivin Mike Anderson , Rengifo-Del Aguila Sofia , Hernández-Amasifuen Angel David , Arévalo-Rojas Víctor Manuel , Acosta-Córdova Ronny Anthony , Cerna-Mendoza Agustín , de Araújo Mastrangelo Thiago , Valverde-Iparraguirre Jorge Damian , Guerrero-Abad Juan Carlos
Published: December 2023

Plukenetia volubilis (“sacha inchi”) is a perennial plant that produces edible seeds with a remarkable lipid composition that is highly concentrated in polyunsaturated essential fatty acids. Inca nut seeds have potential use for lowering malnutrition, enhancing sustainable food production systems, reforestation, and the pharmaceutical industry. The establishment of genetic variability, through spontaneous mutations or induced mutations, can bring desirable and undesirable agronomic traits. Our research focused on studying the impact of gamma radiation on P. volubilis seeds during their germination and vegetative growth. For this purpose, we exposed seeds to different doses of gamma irradiation (0, 500, 550, 600, 650, 700, 750, 800, and 900 Gy) and planted them under in vitro and greenhouse conditions following a completely random design. Our findings showed that gamma radiation treatments did not affect the germination of P. volubilis seeds but affected its root tip growth. An analysis on morphological and physiological parameters revealed a reduction in seedling size and weight when the irradiation doses were increased. Also, the pattern of plant organ development changed as its gamma irradiation was increased. Finally, our analysis found that median lethal dose (LD50) for P. volubilis L. seeds is 618.78 Gy. Our findings can be used as an important reference for plant breeding in this species.
Supplementary Table from DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib Resistance in Clear Cell Renal Cell Carcinoma
Authors: Chang Kun , Chen Yingji , Zhang Xuanzhi , Zhang Wei , Xu Ning , Zeng Bohan , Wang Yue , Feng Tao , Dai Bo , Xu Fujiang , Ye Dingwei , Wang Chenji
Published: December 2023

Supplementary Table 1-6
Supplementary Table S1 from Fatty Acid Oxidation Mediated by Malonyl-CoA Decarboxylase Represses Renal Cell Carcinoma Progression
Authors: Zhou Lijie , Luo Yongbo , Liu Yuenan , Zeng Youmiao , Tong Junwei , Li Mengting , Hou Yaxin , Du Kaixuan , Qi Yabin , Pan Wenbang , Liu Yuanhao , Wang Rongli , Tian Fengyan , Gu Chaohui , Chen Ke
Published: December 2023

The list of translation factor activity-related genes
Table S6 from Neurotransmitter Receptor HTR2B Regulates Lipid Metabolism to Inhibit Ferroptosis in Gastric Cancer
Authors: Tu Ru-Hong , Wu Sheng-Ze , Huang Ze-Ning , Zhong Qing , Ye Yin-Hua , Zheng Chao-Hui , Xie Jian-Wei , Wang Jia-Bin , Lin Jian-Xian , Chen Qi-Yue , Huang Chang-Ming , Lin Mi , Lu Jun , Cao Long-Long , Li Ping
Published: December 2023

Clinicopathological characteristics of 188 patients with gastric cancer in Fujian Medical University Union Hospital (FJMUUH)
Table S5 from Neurotransmitter Receptor HTR2B Regulates Lipid Metabolism to Inhibit Ferroptosis in Gastric Cancer
Authors: Tu Ru-Hong , Wu Sheng-Ze , Huang Ze-Ning , Zhong Qing , Ye Yin-Hua , Zheng Chao-Hui , Xie Jian-Wei , Wang Jia-Bin , Lin Jian-Xian , Chen Qi-Yue , Huang Chang-Ming , Lin Mi , Lu Jun , Cao Long-Long , Li Ping
Published: December 2023

Clinical characteristics of each sample used in scRNA-seq study
Supplementary Data 4 from Neurotransmitter Receptor HTR2B Regulates Lipid Metabolism to Inhibit Ferroptosis in Gastric Cancer
Authors: Tu Ru-Hong , Wu Sheng-Ze , Huang Ze-Ning , Zhong Qing , Ye Yin-Hua , Zheng Chao-Hui , Xie Jian-Wei , Wang Jia-Bin , Lin Jian-Xian , Chen Qi-Yue , Huang Chang-Ming , Lin Mi , Lu Jun , Cao Long-Long , Li Ping
Published: December 2023

GSEA in sc-RNA seq between tumor cells with and without HTR2B expression
Figure S4 from CK1δ and CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple Myeloma
Authors: Burger Karen L. , Fernandez Mario R. , Meads Mark B. , Sudalagunta Praneeth , Oliveira Paula S. , Renatino Canevarolo Rafael , Alugubelli Raghunandan Reddy , Tungsevik Alexandre , De Avila Gabe , Silva Maria , Graeter Allison I. , Dai Hongyue A. , Vincelette Nicole D. , Prabhu Antony , Magaletti Dario , Yang Chunying , Li Weimin , Kulkarni Amit , Hampton Oliver , Koomen John M. , Roush William R. , Monastyrskyi Andrii , Berglund Anders E. , Silva Ariosto S. , Cleveland John L. , Shain Kenneth H.
Published: December 2023

Supplementary Figure S4
Figure S3 from CK1δ and CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple Myeloma
Authors: Burger Karen L. , Fernandez Mario R. , Meads Mark B. , Sudalagunta Praneeth , Oliveira Paula S. , Renatino Canevarolo Rafael , Alugubelli Raghunandan Reddy , Tungsevik Alexandre , De Avila Gabe , Silva Maria , Graeter Allison I. , Dai Hongyue A. , Vincelette Nicole D. , Prabhu Antony , Magaletti Dario , Yang Chunying , Li Weimin , Kulkarni Amit , Hampton Oliver , Koomen John M. , Roush William R. , Monastyrskyi Andrii , Berglund Anders E. , Silva Ariosto S. , Cleveland John L. , Shain Kenneth H.
Published: December 2023

Supplementary Figure S3
Figure S8 from Neurotransmitter Receptor HTR2B Regulates Lipid Metabolism to Inhibit Ferroptosis in Gastric Cancer
Authors: Tu Ru-Hong , Wu Sheng-Ze , Huang Ze-Ning , Zhong Qing , Ye Yin-Hua , Zheng Chao-Hui , Xie Jian-Wei , Wang Jia-Bin , Lin Jian-Xian , Chen Qi-Yue , Huang Chang-Ming , Lin Mi , Lu Jun , Cao Long-Long , Li Ping
Published: December 2023

Supplementary Figure 8. ABCD1 modulates lipid metabolism to attenuate lipid peroxidation. (A-C) AGS and HGC-27 cells from both si-control and si-ABCD1 groups were treated with vehicle or 5-HT (10 μM) for 48 h. Representative confocal images show fluorescence staining in AGS (A) and HGC-27 cells (C) using C11-BODIPY dye. (B) The rate of intracellular lipid ROS in AGS cells was measured by C11-BODIPY fluorescence (n = 3). **p < 0.01; ns, not significant. (D) Expression levels of HIF1α, ABCD1, ACSl4, and GPX4 were evaluated by immunoblot analysis in AGS and HGC-27 cells after 24h treatment with vehicle or 5-HT (10 μM) under normoxic (20% O2) or hypoxic (1% O2) conditions. (E) Representative IHC images showing HIF1α expression in subcutaneous xenograft tumor tissues from SB204741-treated vs. control groups and sh-HTR2B vs. sh-vector groups. (F) After treatment with PP2 (50 nM), AGS and HGC-27 cells were cultured with 5-HT (10 μM) for another 24 h. Levels of Fyn, HIF1α, ABCD1, and phosphorylated and total forms of Akt and mTOR were assessed by immunoblot. (G and H) Representative IHC images of p85 (G) and Fyn (H) from SB204741-treated vs. control or sh-HTR2B vs. sh-vector groups in subcutaneous xenograft tumor tissues.
Figure S5 from Neurotransmitter Receptor HTR2B Regulates Lipid Metabolism to Inhibit Ferroptosis in Gastric Cancer
Authors: Tu Ru-Hong , Wu Sheng-Ze , Huang Ze-Ning , Zhong Qing , Ye Yin-Hua , Zheng Chao-Hui , Xie Jian-Wei , Wang Jia-Bin , Lin Jian-Xian , Chen Qi-Yue , Huang Chang-Ming , Lin Mi , Lu Jun , Cao Long-Long , Li Ping
Published: December 2023

Supplementary Figure 5. The effect of HTR2B on lipid peroxidation in the presence of FBS or hydrogen peroxide. (A-C) AGS and HGC-27 cells were treated with 100 μM SB204741, or 10% (v/v) FBS for 48 h. (A) Rates of intracellular lipid ROS in AGS and HGC-27 cells were determined using C11-BODIPY fluorescence (n = 3). ns, not significant. (B and C) Representative confocal images showing fluorescence staining of lipid ROS in AGS (B) and HGC-27 (C) cells using C11-BODIPY dye. (D-F) After initial treatment with H2O2 (500 μM) for 1 h, AGS cells were incubated with vehicle or 5-HT (10 μM) for another 24 h. (D) Representative confocal images of AGS cells stained with DCFH-DA dye. (E) Representative confocal micrographs showing fluorescence staining in AGS cells using C11-BODIPY dye. (F) Intracellular lipid ROS levels in AGS cells were quantified by C11-BODIPY fluorescence (n = 3). ****p < 0.0001.
Table S1 from The Tumor Immune Microenvironment Architecture Correlates with Risk of Recurrence in Head and Neck Squamous Cell Carcinoma
Authors: Weed Donald T. , Zilio Serena , McGee Christie , Marnissi Boutheina , Sargi Zoukaa , Franzmann Elizabeth , Thomas Giovana , Leibowitz Jason , Nicolli Elizabeth , Arnold David , Bicciato Silvio , Serafini Paolo
Published: December 2023

Numeric data describing a) sample composition, analysis parameters, and phenotyping; b)
phenotype composition of the merged dataset and of each single sample; c) cell type composition (number of
cells) of cellular neighborhoods identified at W=10 and K=14; d) Number of cells assigned to each of the 11
cellular neighborhoods identified at W=10 and K=14; e): relative cell-cell contact frequencies (RF) for all
phenotypes in TLS1 and TLS2 CNs across all patients; f) relative cell-cell contact frequencies (RF) for all
phenotypes in hot and cold tumor CNs across all patients
Supplementary Table S10 from The BRD4–NUT Fusion Alone Drives Malignant Transformation of NUT Carcinoma
Authors: Durall R. Taylor , Huang Julianna , Wojenski Luke , Huang Yeying , Gokhale Prafulla C. , Leeper Brittaney A. , Nash Joshua O. , Ballester Pedro L. , Davidson Scott , Shlien Adam , Sotirakis Emmanuel , Bertaux Fabien , Dubus Vincent , Luo Jia , Wu Catherine J. , Keskin Derin B. , Eagen Kyle P. , Shapiro Geoffrey I. , French Christopher A.
Published: December 2023

Supplementary Table S10. OTTER scores for hNC tumors, including all clusters with score > 0.05.
Supplementary Table S1 from The BRD4–NUT Fusion Alone Drives Malignant Transformation of NUT Carcinoma
Authors: Durall R. Taylor , Huang Julianna , Wojenski Luke , Huang Yeying , Gokhale Prafulla C. , Leeper Brittaney A. , Nash Joshua O. , Ballester Pedro L. , Davidson Scott , Shlien Adam , Sotirakis Emmanuel , Bertaux Fabien , Dubus Vincent , Luo Jia , Wu Catherine J. , Keskin Derin B. , Eagen Kyle P. , Shapiro Geoffrey I. , French Christopher A.
Published: December 2023

Supplementary Table S1. Genotyping primers.
Supplementary Data from Combinatorial Treatment with PARP and MAPK Inhibitors Overcomes Phenotype Switch-Driven Drug Resistance in Advanced Melanoma
Authors: Ferretti Lorenza P. , Böhi Flurina , Leslie Pedrioli Deena M. , Cheng Phil F. , Ferrari Elena , Baumgaertner Petra , Alvarado-Diaz Abdiel , Sella Federica , Cereghetti Alessandra , Turko Patrick , Wright Roni H. , De Bock Katrien , Speiser Daniel E. , Ferrari Roberto , Levesque Mitchell P. , Hottiger Michael O.
Published: December 2023

Contains supplementary tables, figures and materials and methods.
Supplementary Fig. S7 from EZH2 Cooperates with BRD4-NUT to Drive NUT Carcinoma Growth by Silencing Key Tumor Suppressor Genes
Authors: Huang Yeying , Durall R. Taylor , Luong Nhi M. , Hertzler Hans J. , Huang Julianna , Gokhale Prafulla C. , Leeper Brittaney A. , Persky Nicole S. , Root David E. , Anekal Praju V. , Montero Llopis Paula D.L.M. , David Clement N. , Kutok Jeffery L. , Raimondi Alejandra , Saluja Karan , Luo Jia , Zahnow Cynthia A. , Adane Biniam , Stegmaier Kimberly , Hawkins Catherine E. , Ponne Christopher , Le Quan , Shapiro Geoffrey I. , Lemieux Madeleine E. , Eagen Kyle P. , French Christopher A.
Published: December 2023

Supplementary Fig. S7
Supplementary Fig. S3 from EZH2 Cooperates with BRD4-NUT to Drive NUT Carcinoma Growth by Silencing Key Tumor Suppressor Genes
Authors: Huang Yeying , Durall R. Taylor , Luong Nhi M. , Hertzler Hans J. , Huang Julianna , Gokhale Prafulla C. , Leeper Brittaney A. , Persky Nicole S. , Root David E. , Anekal Praju V. , Montero Llopis Paula D.L.M. , David Clement N. , Kutok Jeffery L. , Raimondi Alejandra , Saluja Karan , Luo Jia , Zahnow Cynthia A. , Adane Biniam , Stegmaier Kimberly , Hawkins Catherine E. , Ponne Christopher , Le Quan , Shapiro Geoffrey I. , Lemieux Madeleine E. , Eagen Kyle P. , French Christopher A.
Published: December 2023

Supplementary Fig. S3
Data from DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib Resistance in Clear Cell Renal Cell Carcinoma
Authors: Chang Kun , Chen Yingji , Zhang Xuanzhi , Zhang Wei , Xu Ning , Zeng Bohan , Wang Yue , Feng Tao , Dai Bo , Xu Fujiang , Ye Dingwei , Wang Chenji
Published: December 2023

Abstract
The KEAP1-NRF2 axis is the principal regulator of cellular responses to oxidative and electrophilic stressors. NRF2 hyperactivation is frequently observed in many types of cancer and promotes cancer initiation, progression, metastasis, and resistance to various therapies. Here, we determined that dipeptidyl peptidase 9 (DPP9) is a regulator of the KEAP1-NRF2 pathway in clear cell renal cell carcinoma (ccRCC). DPP9 was markedly overexpressed at the mRNA and protein levels in ccRCC, and high DPP9 expression levels correlated with advanced tumor stage and poor prognosis in patients with ccRCC. Protein affinity purification to identify functional partners of DPP9 revealed that it bound to KEAP1 via a conserved ESGE motif. DPP9 disrupted KEAP1-NRF2 binding by competing with NRF2 for binding to KEAP1 in an enzyme-independent manner. Upregulation of DPP9 led to stabilization of NRF2, driving NRF2-dependent transcription and thereby decreasing cellular reactive oxygen species levels. Moreover, DPP9 overexpression suppressed ferroptosis and induced resistance to sorafenib in ccRCC cells, which was largely dependent on the NRF2 transcriptional target SLC7A11. Collectively, these findings indicate that the accumulation of DPP9 results in hyperactivation of the NRF2 pathway to promote tumorigenesis and intrinsic drug resistance in ccRCC.
Significance:
DPP9 overcomes oxidative stress and suppresses ferroptosis in ccRCC by binding to KEAP1 and promoting NRF2 stability, which drives tumor development and sorafenib resistance.
Neurotransmitter Receptor HTR2B Regulates Lipid Metabolism to Inhibit Ferroptosis in Gastric Cancer
Authors: Tu Ru-Hong , Wu Sheng-Ze , Huang Ze-Ning , Zhong Qing , Ye Yin-Hua , Zheng Chao-Hui , Xie Jian-Wei , Wang Jia-Bin , Lin Jian-Xian , Chen Qi-Yue , Huang Chang-Ming , Lin Mi , Lu Jun , Cao Long-Long , Li Ping
Published: December 2023

Nerves can support tumor development by secreting neurotransmitters that promote cancer cell proliferation and invasion. 5-Hydroxytryptamine (5-HT) is a critical neurotransmitter in the gastrointestinal nervous system, and 5-HT signaling has been shown to play a role in tumorigenesis. Here, we found that expression of the 5-HT receptor HTR2B was significantly elevated in human gastric adenocarcinoma tissues compared with nontumor tissues, and high HTR2B expression corresponded to shorter patient survival. Both 5-HT and a specific HTR2B agonist enhanced gastric adenocarcinoma cell viability under metabolic stress, reduced cellular and lipid reactive oxygen species, and suppressed ferroptosis; conversely, HTR2B loss or inhibition with a selective HTR2B antagonist yielded the inverse tumor suppressive effects. In a patient-derived xenograft tumor model, HTR2B-positive tumors displayed accelerated growth, which was inhibited by HTR2B antagonists. Single-cell analysis of human gastric adenocarcinoma tissues revealed enrichment of PI3K/Akt/mTOR and fatty acid metabolism–related gene clusters in cells expressing HTR2B compared with HTR2B-negative cells. Mechanistically, HTR2B cooperated with Fyn to directly regulate p85 activity and trigger the PI3K/Akt/mTOR signaling pathway, which led to increased expression of HIF1α and ABCD1 along with decreased levels of lipid peroxidation and ferroptosis. Together, these findings demonstrate that HTR2B activity modulates PI3K/Akt/mTOR signaling to stimulate gastric cancer cell survival and indicate that HTR2B expression could be a potential prognostic biomarker in patients with gastric cancer.

Significance:

Nerve cancer cross-talk mediated by HTR2B inhibits lipid peroxidation and ferroptosis in gastric cancer cells and promotes viability under metabolic stress, resulting in increased tumor growth and decreased patient survival.
Osteoclast Cancer Cell Metabolic Cross-talk Confers PARP Inhibitor Resistance in Bone Metastatic Breast Cancer
Authors: Fan Huijuan , Xu Zhanao , Yao Ke , Zheng Bingxin , Zhang Yuan , Wang Xuxiang , Zhang Tengjiang , Li Xuan , Hu Haitian , Yue Bin , Hu Zeping , Zheng Hanqiu
Published: December 2023

The majority of patients with late-stage breast cancer develop distal bone metastases. The bone microenvironment can affect response to therapy, and uncovering the underlying mechanisms could help identify improved strategies for treating bone metastatic breast cancer. Here, we observed that osteoclasts reduced the sensitivity of breast cancer cells to DNA damaging agents, including cisplatin and the PARP inhibitor (PARPi) olaparib. Metabolic profiling identified elevated glutamine production by osteoclasts. Glutamine supplementation enhanced the survival of breast cancer cells treated with DNA damaging agents, while blocking glutamine uptake increased sensitivity and suppressed bone metastasis. GPX4, the critical enzyme responsible for glutathione oxidation, was upregulated in cancer cells following PARPi treatment through stress-induced ATF4-dependent transcriptional programming. Increased glutamine uptake and GPX4 upregulation concertedly enhanced glutathione metabolism in cancer cells to help neutralize oxidative stress and generate PARPi resistance. Analysis of paired patient samples of primary breast tumors and bone metastases revealed significant induction of GPX4 in bone metastases. Combination therapy utilizing PARPi and zoledronate, which blocks osteoclast activity and thereby reduces the microenvironmental glutamine supply, generated a synergistic effect in reducing bone metastasis. These results identify a role for glutamine production by bone-resident cells in supporting metastatic cancer cells to overcome oxidative stress and develop resistance to DNA-damaging therapies.

Significance:

Metabolic interaction between osteoclasts and tumor cells contributes to resistance to DNA-damaging agents, which can be blocked by combination treatment with PARP and osteoclast inhibitors to reduce bone metastatic burden.
Supplementary Table S6 from Tamoxifen Response at Single-Cell Resolution in Estrogen Receptor–Positive Primary Human Breast Tumors
Authors: Kim Hyunsoo , Whitman Austin A. , Wisniewska Kamila , Kakati Rasha T. , Garcia-Recio Susana , Calhoun Benjamin C. , Franco Hector L. , Perou Charles M. , Spanheimer Philip M.
Published: December 2023

Comparison of tamoxifen and control treated non-malignant cell subpopulations within the selected 4 pairs of ER+/HER2- tumors
Supplementary Table S2 from Tamoxifen Response at Single-Cell Resolution in Estrogen Receptor–Positive Primary Human Breast Tumors
Authors: Kim Hyunsoo , Whitman Austin A. , Wisniewska Kamila , Kakati Rasha T. , Garcia-Recio Susana , Calhoun Benjamin C. , Franco Hector L. , Perou Charles M. , Spanheimer Philip M.
Published: December 2023

Comparison of Normal_01 with/without 12hr suspension
Supplementary Table S1 from Tamoxifen Response at Single-Cell Resolution in Estrogen Receptor–Positive Primary Human Breast Tumors
Authors: Kim Hyunsoo , Whitman Austin A. , Wisniewska Kamila , Kakati Rasha T. , Garcia-Recio Susana , Calhoun Benjamin C. , Franco Hector L. , Perou Charles M. , Spanheimer Philip M.
Published: December 2023

Representativeness of Study Participants
Supplementary Figure S3 from Tamoxifen Response at Single-Cell Resolution in Estrogen Receptor–Positive Primary Human Breast Tumors
Authors: Kim Hyunsoo , Whitman Austin A. , Wisniewska Kamila , Kakati Rasha T. , Garcia-Recio Susana , Calhoun Benjamin C. , Franco Hector L. , Perou Charles M. , Spanheimer Philip M.
Published: December 2023

Tumor-specific cell annotations and tamoxifen-regulated genes
Supplementary Figure S1 from Tamoxifen Response at Single-Cell Resolution in Estrogen Receptor–Positive Primary Human Breast Tumors
Authors: Kim Hyunsoo , Whitman Austin A. , Wisniewska Kamila , Kakati Rasha T. , Garcia-Recio Susana , Calhoun Benjamin C. , Franco Hector L. , Perou Charles M. , Spanheimer Philip M.
Published: December 2023

Effect of time in suspension on cell population abundance and gene expression.
Supplementary Table S4 from Differential Benefit of Metronomic Chemotherapy Among Triple-Negative Breast Cancer Subtypes Treated in the IBCSG Trial 22–00
Authors: Joaquin Garcia Andrea , Rediti Mattia , Venet David , Majjaj Samira , Kammler Roswitha , Munzone Elisabetta , Gianni Lorenzo , Thürlimann Beat , Laáng István , Colleoni Marco , Loi Sherene , Viale Giuseppe , Regan Meredith M. , Buisseret Laurence , Rothé Françoise , Sotiriou Christos
Published: December 2023

Clinic-pathologic characteristics of the different treatment arms.
Supplementary Figure S14 from Differential Benefit of Metronomic Chemotherapy Among Triple-Negative Breast Cancer Subtypes Treated in the IBCSG Trial 22–00
Authors: Joaquin Garcia Andrea , Rediti Mattia , Venet David , Majjaj Samira , Kammler Roswitha , Munzone Elisabetta , Gianni Lorenzo , Thürlimann Beat , Laáng István , Colleoni Marco , Loi Sherene , Viale Giuseppe , Regan Meredith M. , Buisseret Laurence , Rothé Françoise , Sotiriou Christos
Published: December 2023

Cox proportional-hazard analysis for low-dose CM treatment effect on different OS, DRFI and BCFI according to the different immune cell gene expression signatures.
Supplementary Figure S12 from Differential Benefit of Metronomic Chemotherapy Among Triple-Negative Breast Cancer Subtypes Treated in the IBCSG Trial 22–00
Authors: Joaquin Garcia Andrea , Rediti Mattia , Venet David , Majjaj Samira , Kammler Roswitha , Munzone Elisabetta , Gianni Lorenzo , Thürlimann Beat , Laáng István , Colleoni Marco , Loi Sherene , Viale Giuseppe , Regan Meredith M. , Buisseret Laurence , Rothé Françoise , Sotiriou Christos
Published: December 2023

Kaplan-Meier estimates for OS, DFS, DRFI and BCFI measures according to CM maintenance in LPBC tumors.
Supplementary Table 1 from Impact of Frontline Ivosidenib on Volumetric Growth Patterns in Isocitrate Dehydrogenase–mutant Astrocytic and Oligodendroglial Tumors
Authors: Kamson David Olayinka , Puri Sushant , Sang Yingying , Shi Meihui Jessica , Blair Lindsay , Blakeley Jaishri O. , Laterra John
Published: December 2023

Supplementary Table 1 - Detailed volumetric data for each patient.
Supplementary Table S5 from Olaparib and Ceralasertib (AZD6738) in Patients with Triple-Negative Advanced Breast Cancer: Results from Cohort E of the plasmaMATCH Trial (CRUK/15/010)
Authors: Ring Alistair , Kilburn Lucy S. , Pearson Alex , Moretti Laura , Afshari-Mehr Angelica , Wardley Andrew M. , Gurel Bora , Macpherson Iain R. , Riisnaes Ruth , Baird Richard D. , Martin Sue , Roylance Rebecca , Johnson Hannah , Ferreira Ana , Winter Matthew C. , Dunne Kathryn , Copson Ellen , Hickish Tamas , Burcombe Russell , Randle Kat , Serra Violeta , Llop-Guevara Alba , Bliss Judith M. , Turner Nicolas C.
Published: December 2023

Table S5. Worst grade CTCAE reported during treatment
Supplementary Figure S2 from Upregulation of Indoleamine 2,3-Dioxygenase 1 in Tumor Cells and Tertiary Lymphoid Structures is a Hallmark of Inflamed Non–Small Cell Lung Cancer
Authors: Bessede Alban , Peyraud Florent , Le Moulec Sylvestre , Cousin Sophie , Cabart Mathilde , Chomy François , Rey Christophe , Lara Oren , Odin Ophélie , Nafia Imane , Guegan Jean-Philippe , Italiano Antoine
Published: December 2023

Representative image field of CD8 / CD163 / IDO1 / PanCK / PD1 / PDL1 / DAPI multiplexed immunofluorescence panel on a lung adenocarcinoma section.
Supplementary Table ST2 from PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors
Authors: Stokes Michael E. , Calvo Veronica , Fujisawa Sho , Dudgeon Crissy , Huang Sharon , Ballal Nupur , Shen Leyi , Gasparek Jennifer , Betzenhauser Matthew , Taylor Simon J. , Staschke Kirk A. , Rigby Alan C. , Mulvihill Mark J. , Bose Nandita , Lightcap Eric S. , Surguladze David
Published: December 2023

Pharmacokinetic (PK) table of HC-5404 in mouse plasma.
Supplementary Table S1 from Olaparib and Ceralasertib (AZD6738) in Patients with Triple-Negative Advanced Breast Cancer: Results from Cohort E of the plasmaMATCH Trial (CRUK/15/010)
Authors: Ring Alistair , Kilburn Lucy S. , Pearson Alex , Moretti Laura , Afshari-Mehr Angelica , Wardley Andrew M. , Gurel Bora , Macpherson Iain R. , Riisnaes Ruth , Baird Richard D. , Martin Sue , Roylance Rebecca , Johnson Hannah , Ferreira Ana , Winter Matthew C. , Dunne Kathryn , Copson Ellen , Hickish Tamas , Burcombe Russell , Randle Kat , Serra Violeta , Llop-Guevara Alba , Bliss Judith M. , Turner Nicolas C.
Published: December 2023

Table S1. Additional baseline characteristics
Supplementary Figure S1 from Olaparib and Ceralasertib (AZD6738) in Patients with Triple-Negative Advanced Breast Cancer: Results from Cohort E of the plasmaMATCH Trial (CRUK/15/010)
Authors: Ring Alistair , Kilburn Lucy S. , Pearson Alex , Moretti Laura , Afshari-Mehr Angelica , Wardley Andrew M. , Gurel Bora , Macpherson Iain R. , Riisnaes Ruth , Baird Richard D. , Martin Sue , Roylance Rebecca , Johnson Hannah , Ferreira Ana , Winter Matthew C. , Dunne Kathryn , Copson Ellen , Hickish Tamas , Burcombe Russell , Randle Kat , Serra Violeta , Llop-Guevara Alba , Bliss Judith M. , Turner Nicolas C.
Published: December 2023

Figure S1. CONSORT diagram
Supplementary Table S4 from Comparative Genomic Analysis and Clinical Outcomes of BRAF-mutated Advanced Biliary Tract Cancers
Authors: Tang Tin-Yun , Nichetti Federico , Kaplan Ben , Lonardi Sara , Pietrantonio Filippo , Salvatore Lisa , Vivaldi Caterina , Rimassa Lorenza , de Braud Filippo , Rizzato Mario Domenico , Pavlick Dean , Chu Randy , Danner De Armas Anaemy , Sharaf Radwa , Sokol Ethan , Rodon Ahnert Jordi , Ross Jeffrey S. , Javle Milind , Niger Monica
Published: December 2023

Supplemental Table S4: OS Cox Regression with Univariate, Full Multivariate, and Explanatory Multivariate Analysis
Supplementary Table S3 from Comparative Genomic Analysis and Clinical Outcomes of BRAF-mutated Advanced Biliary Tract Cancers
Authors: Tang Tin-Yun , Nichetti Federico , Kaplan Ben , Lonardi Sara , Pietrantonio Filippo , Salvatore Lisa , Vivaldi Caterina , Rimassa Lorenza , de Braud Filippo , Rizzato Mario Domenico , Pavlick Dean , Chu Randy , Danner De Armas Anaemy , Sharaf Radwa , Sokol Ethan , Rodon Ahnert Jordi , Ross Jeffrey S. , Javle Milind , Niger Monica
Published: December 2023

Supplemental Table S3: PFS Cox Regression with Univariate, Full Multivariate, and Explanatory Multivariate Analysis
Supplementary Figure 8 from Suppression of Tumor Cell Lactate-generating Signaling Pathways Eradicates Murine PTEN/p53-deficient Aggressive-variant Prostate Cancer via Macrophage Phagocytosis
Authors: Chaudagar Kiranj , Hieromnimon Hanna M. , Kelley Anne , Labadie Brian , Shafran Jordan , Rameshbabu Srikrishnan , Drovetsky Catherine , Bynoe Kaela , Solanki Ani , Markiewicz Erica , Fan Xiaobing , Loda Massimo , Patnaik Akash
Published: December 2023

PI3Ki + MEKi + PORCNi combination therapy elicits a 100% response rate in PTEN/p53-deficient GEMMs via TAM activation
Supplementary Figure 4 from Suppression of Tumor Cell Lactate-generating Signaling Pathways Eradicates Murine PTEN/p53-deficient Aggressive-variant Prostate Cancer via Macrophage Phagocytosis
Authors: Chaudagar Kiranj , Hieromnimon Hanna M. , Kelley Anne , Labadie Brian , Shafran Jordan , Rameshbabu Srikrishnan , Drovetsky Catherine , Bynoe Kaela , Solanki Ani , Markiewicz Erica , Fan Xiaobing , Loda Massimo , Patnaik Akash
Published: December 2023

PI3Ki/MEKi combination therapy suppresses histone lactylation in 80% of Pb-Cre;PTENfl/flTrp53fl/fl mice
Supplementary Figure 2 from Suppression of Tumor Cell Lactate-generating Signaling Pathways Eradicates Murine PTEN/p53-deficient Aggressive-variant Prostate Cancer via Macrophage Phagocytosis
Authors: Chaudagar Kiranj , Hieromnimon Hanna M. , Kelley Anne , Labadie Brian , Shafran Jordan , Rameshbabu Srikrishnan , Drovetsky Catherine , Bynoe Kaela , Solanki Ani , Markiewicz Erica , Fan Xiaobing , Loda Massimo , Patnaik Akash
Published: December 2023

MEKi has modest anti-proliferative and pro-apoptotic effects on AC1 cells, but not SC1 cells
Supp Table 4 from ATM Mutations Associate with Distinct Co-Mutational Patterns and Therapeutic Vulnerabilities in NSCLC
Authors: Vokes Natalie I. , Galan Cobo Ana , Fernandez-Chas Margarita , Molkentine David , Treviño Santiago , Druker Vitaly , Qian Yu , Patel Sonia , Schmidt Stephanie , Hong Lingzhi , Lewis Jeff , Rinsurongkawong Waree , Rinsurongkawong Vadeerat , Lee J. Jack , Negrao Marcelo V. , Gibbons Don L. , Vaporciyan Ara , Le Xiuning , Wu Jia , Zhang Jianjun , Rigney Una , Iyer Sonia , Dean Emma , Heymach John V.
Published: December 2023

Supp Table 4. ATM co-mutation enrichment analysis in KRAS wild-type tumors, in meta-analysis and within individual cohorts.
Supplementary Figure 10 from Suppression of Tumor Cell Lactate-generating Signaling Pathways Eradicates Murine PTEN/p53-deficient Aggressive-variant Prostate Cancer via Macrophage Phagocytosis
Authors: Chaudagar Kiranj , Hieromnimon Hanna M. , Kelley Anne , Labadie Brian , Shafran Jordan , Rameshbabu Srikrishnan , Drovetsky Catherine , Bynoe Kaela , Solanki Ani , Markiewicz Erica , Fan Xiaobing , Loda Massimo , Patnaik Akash
Published: December 2023

PORCNi in combination with PI3Ki + MEKi inhibits lactate production from PTEN/p53-deficient GEMM tumor-derived PC cells