bluuebunny/crossref_metadata_2025 huggingface dataset:
ПОПЕРЕДЖЕННЯ ПСИХОТРАВМ ПРИ РІЗНИХ РЕАКЦІЯХ НА ВПЛИВ ПСИХОГЕННИХ ЧИННИКІВ
Authors: ГІРЧЕНКО Олена
Published: April 2023

У статті розглянуто поняття психотравми, наведено теоретичний аналіз проблеми дослідження психотравм при різних реакціях на вплив психогенних факторів (чинників),досліджено психогенні фактори та їх вплив на психіку військовослужбовців.

Мета статті полягає у дослідженні закономірностей впливу психотравм при різних реакціях на психогенні фактори.

Важливість психологічного вивчення феномену «психотравма», її психологічний зміст та структура, значення у змінах стану психічного та фізичного здоров'я людини, постійно відзначається вченими з різних галузей психологічної науки (загальна психологія, медична психологія, психофізіологія, інженерна психологія, практична психологія, спортивна психологія та ін.), вченими граничних та дружніх галузей знань (медицина, валеологія, педагогіка, фізкультура та диспут та ін.). У вітчизняній психології вивчення проблеми «психотравми» досить рідкісні та мають розсіяний та фрагментарний характер. Здебільшого, це пов'язано з відомими соціальними причинами – умовами, які відображають сприйняття людиною навколишньої реальності як загрозливої та нестійкої.

Детально розглянувши сучасний стан вивчення феномену «психотравма», його психологічний зміст, можна дійти висновку, що сьогоднішній стан суспільства характеризується посиленням дії факторів, які сприяють психічній травматизації особистості. і зниження якості життя людини. До таких чинників належать: відносно нестабільна політична ситуація в країні та світі, соціально-економічна невизначеність і тривога, екстремальні життєві події (пандемія, війна, міграція).

На нашу думку, психологічна травма або психотравма – це пошкодження від впливу на психіку людини негативних факторів, які можуть сприяти розвитку психічних захворювань. Часто наявність психологічної травми може призвести до того, що людині знадобиться лікування посттравматичного стресового розладу. Психотравма може бути пов'язана з фізичною травмою, що загрожує життю людини або порушує почуття безпеки, що супроводжується сильним емоційним потрясінням.
Circ_0067997 boosted the growth while repressed the apoptosis of SGC-7901/DDP cells via repressing miR-615-5p/AKT1 pathway
Authors: Jiao Yuwen , Fu Yue , Gong Yu , Wang Guangyao , Chen Shuai , Cai Gengdi , Wu Siyuan , Tang Liming
Published: April 2023

BACKGROUND: Gastric cancer (GC) remains a huge challenge to the heathy of human beings, largely due to lacking of effective therapeutic measures. Though an oncogenic role for circular RNAs (circRNAs) circ_0067997 in the progression of GC has been described recently, the molecular modulatory mechanism of it still remains to be further explored. The aim of present study is to examine the molecular network of circ_0067997 in GC. METHODS: qRT-PCR was carried out to determine the mRNA levels of circ_0067997, miR-615-5p and AKT1 in cisplatin (DDP)-insensitive or sensitive GC tumor tissues and cells, while the correlations among the contents of these molecules were determined by statistical analysis. The expression of circ_0067997 was manipulated by short-hairpin RNA and lentiviral-mediated approaches, while that of miR-615-5p was achieved by the application of its inhibitor or mimic. The in vivo action of circ_0067997 on tumor formation was determined by measuring tumor weight/volume/size and analyzing tumor apoptosis through TUNEL staining in mouse xenograft model and, while the in vitro effects of this circRNA and its target miR-615-5p on the cell survival and death were separately evaluated by CCK-8 assay and flow cytometry. Additionally, luciferase reporter assays were executed to determine the sequentially regulatory relationships of circ_0067997, miR-615-5p, and AKT1. RESULTS: Our data demonstrated that the level of circ_0067997 level was increased in DDP-insensitive GC tissues and cell line, while miR-615-5p presented the opposite results. Moreover, the relationships between circ_0067997 and miR-615-5p levels, circ_0067997 and AKT1 contents presented negative and positive correlations in clinic samples, respectively. Importantly, circ_0067997 was found to repress miR-615-5p expression, consequently leading to increased growth while reduced apoptosis of GC cells in the presence of DDP. Furthermore, the validated sequential regulation was circ_0067997 modulating miR-615-5p adjusting AKT1. CONCLUSIONS: This study demonstrated that circ_0067997 functioned as a sponge of miR-615-5p to target AKT1 expression, thereby enhancing the growth and restricting the apoptosis of DDP-insensitive GC cells. These new findings offered a valuable target for the detection and management of GC.
A novel cuproptosis-related lncRNA signature predicts the prognosis and immunotherapy for hepatocellular carcinoma
Authors: Liu Yanqing , Jiang Jianshuai
Published: April 2023

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most serious malignant tumors with a poor prognosis worldwide. Cuproptosis is a novel copper-dependent cell death form, involving mitochondrial respiration and lipoylated components of the tricarboxylic acid (TCA) cycle. Long non-coding RNAs (lncRNAs) have been demonstrated to affect the tumorigenesis, growth, and metastasis of HCC. OBJECTIVE: We explored the potential roles of cuproptosis-related lncRNAs in predicting the prognosis for HCC. METHODS: The RNA-seq transcriptome data, mutation data, and clinical information data of HCC patients were downloaded from The Cancer Genome Atlas (TCGA) database. The least absolute shrinkage and selection operator (LASSO) algorithm and Cox regression analyses were performed to identify a prognostic cuproptosis-related lncRNA signature. The receiver operating characteristic (ROC) analysis was used to evaluate the predictive value of the lncRNA signature for HCC. The enrichment pathways, immune functions, immune cell infiltration, tumor mutation burden, and drug sensitivity were also analyzed. RESULTS: We constructed a prognostic model consisting of 8 cuproptosis-related lncRNAs for HCC. The patients were divided into high-risk group and low-risk group according to the riskscore calculated using the model. Kaplan-Meier analysis revealed that the high-risk lncRNA signature was correlated with poor overall survival [hazard ratio (HR) =1.009, 95% confidence interval (CI) = 1.002–1.015; p= 0.010)] of HCC. A prognostic nomogram incorporated the lncRNA signature and clinicopathological features were constructed and showed favorable performance for predicting prognosis of HCC patients. In addition, the most immune-related functions were significantly different between the high-risk and low-risk groups. Tumor mutation burden (TMB) and immune checkpoints were also expressed differently between the two risk groups. Finally, HCC patients with low-risk score were more sensitive to several chemotherapy drugs. CONCLUSIONS: The novel cuproptosis-related lncRNA signature could be used to predict prognosis and evaluate the effect of chemotherapy for HCC.
NEURONORMA Cognitive Battery Associations with Cerebrospinal Fluid Amyloid-β and Tau Levels in the Continuum of Alzheimer’s Disease
Authors: García-Escobar Greta , Puig-Pijoan Albert , Puente-Periz Víctor , Fernández-Lebrero Aida , María Manero Rosa , Navalpotro-Gómez Irene , Suárez-Calvet Marc , Grau-Rivera Oriol , Contador-Muñana José , Cascales-Lahoz Diego , Duran-Jordà Xavier , Boltes Núncia , Pont-Sunyer Maria Claustre , Ortiz-Gil Jordi , Carrillo-Molina Sara , López-Villegas María Dolores , Abellán-Vidal María Teresa , Martínez-Casamitjana María Isabel , Hernández-Sánchez Juan José , Padrós-Fluvià Anna , Peña-Casanova Jordi , Sánchez-Benavides Gonzalo
Published: April 2023

Background: Neuropsychological assessments are essential to define the cognitive profile and contribute to the diagnosis of Alzheimer’s disease (AD). The progress in knowledge about the pathophysiological process of the disease has allowed conceptualizing AD through biomarkers as a biological continuum that encompasses different clinical stages. Objective: To explore the association between cerebrospinal fluid (CSF) biomarkers of AD and cognition using the NEURONORMA battery, in a sample of cognitively unimpaired (CU), mild cognitive impaired (MCI), and mild dementia of the Alzheimer type (DAT) subjects, and to characterize the cognitive profiles in MCI subjects classified by A/T/N system. Methods: 42 CU, 35 MCI, and 35 mild DAT were assessed using the NEURONORMA battery. Core AD biomarkers [amyloid-β42 (Aβ42) peptide, total tau (t-tau), and phosphorylated tau 181 (p-tau181)] proteins were measured in CSF. Correlation coefficients, multivariate regression, and effect sizes were calculated. We explored the age- and education-adjusted cognitive profiles by A/T/N variants within the MCI group. Results: Cognitive outcomes were directly associated with CSF Aβ42 and inversely with CSF tau measures. We found differences in both biomarkers and cognitive outcomes comparing all pairs except for CSF measures between cognitively impaired groups. The highest effect size was in memory tasks and biomarkers ratios. Lower performances were in memory and executive domains in MCI subjects with AD pathology (A+T+N±) compared to those with normal levels of AD biomarkers (A– T– N). Conclusion: This study provides further evidence of the validity of Spanish NEURONORMA cognitive battery to characterize cognitive impairment in the AD pathological continuum.
An improved context-aware analysis for sentimental Grass Hopper Optimization algorithm and its post affects on Twitter
Authors: Mudgil Pooja , Gupta Pooja , Mathur Iti , Joshi Nisheeth
Published: April 2023

Social media platforms, namely Instagram, Facebook, Twitter, YouTube, etc. have gained a lot of attention as users used to share their views, and post videos, audio, and pictures for social networking. In near future, understanding the meaning and analyzing this enormously rising volume and size of online data will become a necessity in order to extract valuable information from them. In a similar context, the paper proposes an analysis model in two phases namely the training and the sentiment classification using the reward-based grasshopper optimization algorithm. The training architecture and context analysis of the tweet are presented for the sentiment analysis along with the ground truth processing of emotions. The proposed algorithm is divided into two phases namely the exploitation and the exploration part and creates a reward mechanism that utilizes both phases. The proposed algorithm also uses cosine similarity, dice coefficient, and euclidean distance as the input set and further processes using the grasshopper algorithm. Finally, it presents a combination of swarm intelligence and machine learning for attribute selection in which the reward mechanism is further validated using machine learning techniques. The comparative performance in terms of precision, recall, and F-measure has been measured for the proposed model in comparison to existing swarm-based sentiment analysis works. Overall, simulation analysis showed that the proposed work based on grasshopper optimization outperformed the existing approaches for Sentiment 140 by 5.93% to 10.05% SemEval 2013 by 6.15% to 12.61% and COVID-19 tweets by 2.72% to 9.13%. Thus, demonstrating the efficiency of the context-aware sentiment analysis using the grasshopper optimization approach.
An adaptive incremental TSK fuzzy system based on stochastic configuration and its approximation capability analysis
Authors: Zhou Wei , Wang Degang , Li Hongxing , Bao Menghong
Published: April 2023

The aim of this study is to improve randomized methods for designing a Takagi-Sugeno-Kang (TSK) fuzzy system. A novel adaptive incremental TSK fuzzy system based on stochastic configuration, named stochastic configuration fuzzy system (SCFS), is proposed in this paper. The proposed SCFS determines the appropriate number of fuzzy rules in TSK fuzzy system by incremental learning approach. From the initial system, new fuzzy rules are added incrementally to improve the system performance until the specified performance is achieved. In the process of generation of fuzzy rules, the stochastic configuration supervision mechanism is applied to ensure that the addition of fuzzy rules can continuously improve the performance. The premise parameters of new adding fuzzy rules are randomly assigned adaptively under the supervisory mechanism, and the consequent parameters are evaluated by Moore-Penrose generalized inverse. It has been proved theoretically that the supervisory mechanism can help to ensure the universal approximation of SCFS. The proposed SCFS can reach any predetermined tolerance level when there are enough fuzzy rules, and the training process is finite. A series of synthetic data and benchmark datasets are used to verify SCFS’s performance. According to the experimental results, SCFS achieves satisfactory prediction accuracy compared to other models.
A novel MADM algorithm for teaching quality evaluation of college volleyball training based on 2-tuple linguistic neutrosophic numbers information operators
Authors: Wu Haowen , Rao Fengshuo
Published: April 2023

Teaching quality is the foundation and lifeline of colleges and universities. To establish a distinctive university, we must adhere to the scientific concept of development, deepen teaching reform and improve teaching quality. The classroom teaching quality (CTQ) evaluation of college physical education (PE) is an essential part of the teaching process. Building a scientific, comprehensive, reasonable and effective evaluation system is crucial to improve the quality of college PE classroom teaching. This process is not easy and needs long-term efforts and persistence. The CTQ evaluation of college volleyball training is viewed as the multi-attribute decision-making (MADM). In this paper, we connect the geometric Heronian mean (GHM) operator and power geometric (PG) operator with 2-tuple linguistic neutrosophic sets (2TLNSs) to build the generalized 2-tuple linguistic neutrosophic numbers weighted power GHM (G2TLNWPGHM) operator. Then, the G2TLNWPGHM operator is used to tackle MADM with 2TLNSs. Finally, an example for CTQ evaluation of college volleyball training is used to show the proposed methods.
ITARA and ELECTRE III three-way decision model in the spherical fuzzy environment and its application in customer selection
Authors: Wu Meiqin , Song Jiawen , Fan Jianping
Published: April 2023

As COVID-19 swept through, production in various industries was affected. Epidemic control leads to logistical disruptions from time to time and suppliers have to make production and shipping decisions after analyzing the customer’s situation. Therefore, the majority of manufacturers need to establish effective methods for the selection of distribution customers. The method presented in this paper can classify customers into three regions and rank their status to help suppliers effectively make decisions. The three-way decision (3WD) is a well-known fast sorting method in multi-attribute decision-making (MADM). In this paper, we proposed the 3WD model based on Indifference Threshold based Attribute Ratio Analysis (ITARA), ELimination Et Choix Traduisant la REalite III (ELLECTRE III) in the spherical fuzzy environment. Then, we used the SF-ITARA-ELECTRE III-3WD method to select the suitable customers for dispensing. In addition, comparison with the conventional SF-PROMETHEE-3WD, SF-EVAMIX-3WD, SF-TOPSIS-3WD and SF-VIKOR-3WD are created to verify the effectiveness of the proposed method. An effective risk-averse solution to the MADM problem for spherical fuzzy environment is provided.
Association of use of different type of manual therapy approach with upper extremity pain in manual therapists of Lahore”
Authors: Hafiz Muneeb ur Rehman  , Zulfiqar Hunza , Anwer Hajira , Naina Nayab
Published: April 2023

This study was conducted to assess the upper limb pain in manual physiotherapists by using different manual therapy techniques.There was no such type of study in Pakistan and also there was less literature found  on this study internationally.It was a cross sectional study . Data was collected from the manual physiotherapists of Lahore from different clinical settings. The data collection was done by using Non probability convenient sampling technique. The Sample size was 126, calculated from (“Raosoft” software). The questionnaire used to assess pain was the Standard Nordic musculoskeletal questionnaire. For the statistical analysis, SPSS 20 software was used to find the association of use of a different type of manual therapy approach with upper extremity pain in the manual therapist. The mean age of physiotherapists was 34.6 (SD = 5.996). Out of 126, male physiotherapist 66 and 60 were female. Mostly Physiotherapists who were included in this study had working experience of more than 5 years and practicing more than 3 hours a day had upper limb pain. Physiotherapists using manual therapy techniques Kalterborn technique had more pain in the neck, shoulder, elbow,wrist and hand than physiotherapists using Mulligan and Maitland. There was no association of any technique used by physiotherapists with shoulder, elbow, wrist/hand and neck pain (p>0.05). This study concluded that physiotherapists using Kalternborn technique reported more upper limb pain than therapists using the maitland and mulligan techniques. There was no association of any technique used by  hysiotherapists with shoulder, elbow, wrist/hand and neck pain.
Avaliação de suplemento energético em níveis crescentes no concentrado para ovinos – consumo e bioquímica sanguínea
Authors:   Universidade Federal de Uberlândia, Freitas Ana Beatriz Inácio de , Vilaça Lucas Eduardo Gonçalves ,   Universidade Federal de Uberlândia, Siqueira Marco Túlio Santos ,   Universidade Federal de Lavras, Oliveira Karla Alves ,   Universidade Estadual Paulista “Júlio de Mesquita Filho”, Sousa Luciano Fernandes ,   Universidade Federal do Tocantins, Macedo Júnior Gilberto de Lima ,   Universidade Federal de Uberlândia
Published: April 2023

The objective was to estimate the different levels of inclusion of an energetic supplement in the concentrate in relation to consumption and blood biochemistry. The experiment was carried out with lambs with about eight months of age and an average weight of 40Kg. They were distributed in 5x5 Latin square digestibility study cages with five different treatments: 0%, 5%, 10%, 15%, 20% inclusion in the concentrate. The ewes obtained the different levels of energetic supplement in the concentrate with a ten-day adaptation diet and another five days of collection for each animal receiving each treatment on a diet with a roughage concentrate ratio of 50:50. The animals received an average of 3.5% of the live weight of feed. Feces, leftovers of the offered, leftovers of water were collected and the volume and density of urine were measured during the five days of collections for each animal in each phase. Blood was collected three times during the collection days, alternating days, with the first blood collection, on the first day of data collection for each phase, to determine the concentrations of urea, uric acid, creatinine, albumin, total proteins, cholesterol, glucose and triglycerides. The different levels of inclusion of the product in the concentrate did not influence statistically in relation to consumption, there was a statistical difference in relation to the consumption of dry matter in relation to the live weight (DMF) and in relation to the consumption of dry matter in relation to the metabolic weight (DMF), with variation of polynomial regression. It is observed that as the product is included in the concentrate, the faeces tend to soften and, consequently, the amount of water in the faeces increases. Of the blood parameters, no statistical variation was found.
Effect of marble powder content on compressive strength and water absorption of high-strength concrete
Authors:   Faculty of Civil Engineering, Ho Chi Minh City University of Technology (HCMUT), 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City, Vietnam, Bùi Phương Trinh ,   Vietnam National University Ho Chi Minh City, Linh Trung Ward, Thu Duc City, Ho Chi Minh City, Vietnam, Đào Xuân Hoàng ,   Faculty of Civil Engineering, Ho Chi Minh City University of Technology (HCMUT), 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City, Vietnam ; Vietnam National University Ho Chi Minh City, Linh Trung Ward, Thu Duc City, Ho Chi Minh City, Vietnam, Phạm Phú Nam Trân ,   Faculty of Civil Engineering, Ho Chi Minh City University of Technology (HCMUT), 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City, Vietnam ; Vietnam National University Ho Chi Minh City, Linh Trung Ward, Thu Duc City, Ho Chi Minh City, Vietnam, Phùng Thị Phương Hà ,   Faculty of Civil Engineering, Ho Chi Minh City University of Technology (HCMUT), 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City, Vietnam ; Vietnam National University Ho Chi Minh City, Linh Trung Ward, Thu Duc City, Ho Chi Minh City, Vietnam, Lưu Xuân Lộc ,   Faculty of Civil Engineering, Ho Chi Minh City University of Technology (HCMUT), 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City, Vietnam ; Vietnam National University Ho Chi Minh City, Linh Trung Ward, Thu Duc City, Ho Chi Minh City, Vietnam
Published: April 2023

This paper presents the effect of marble powder content on compressive strength and water absorption of high-strength concrete to expand the utilization of such waste in the construction industry and to reduce the Portland cement production which negatively affects the environment. Mixture proportion of reference concrete without marble powder was designed as per TCVN 10306:2014 with a designed compressive strength at least of 60 MPa and slump of 16 ± 2 cm. To evaluate the effect of marble powder content on compressive strength and water absorption of hardened concrete, the Portland cement was replaced by the marble powder at levels of 0, 5, 10, 15, and 20% by mass. Experimental results showed that the marble powder significantly affected the engineering properties of fresh and hardened concretes, in detail: the replacement of Portland cement by the marble powder from 0 to 20% increased the slump of fresh concrete from 16.0 to 20.5 cm, and the void volume of hardened concrete at the age of 28 days from 2.66 to 4.79%, resulting in the reduction of compressive strength by 2.48–18.60% and the increase in water absorption by 1.59–3.79% when comprared with the reference concrete with 0% marble powder. However, the value of compressive strength at the age of 28 days of hardened concrete using 5–20% marble powder reached 60.94–73.01 MPa, ensuring the requirement in terms of compressive strength of high-strength concrete. In conclusion, the utilization of marble powder as the Portland cement replacement in a range from 5–20% was feasible in making high-strength concrete with compressive strength of above 60 MPa.
Influence of the louver angle on the performance of the air-conditioning outdoor units in high-rise apartment buildings
Authors:   Department of Heat and Refrigeration, Faculty of Mechanical Engineering, Ho Chi Minh City University of Technology (HCMUT), 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City, Vietnam, Nguyen Van Hap ,   Vietnam National University Ho Chi Minh City, Linh Trung Ward, Thu Duc District, Ho Chi Minh City, Vietnam, Nguyễn Minh Phú ,   Faculty of Heat and Refrigeration Engineering, Industrial University of Ho Chi Minh City, Ho Chi Minh City, Viet Nam
Published: April 2023

The split-type air conditioners are widely used in high-rise apartment buildings in the major urban areas, especially Ho Chi Minh City - Vietnam, because of its convenience. In the apartments with limited space, the installation of outdoor units not in accordance with technical guidelines will affect the performance of the air conditioning system and the aesthetics of the apartment building. The aim of this study is to propose the technical room in apartments for properly installing outdoor units of air conditioning systems. The CFD method is utilized through Ansys Fluent software to determine the inlet air temperature of condensers and COP corresponding to the louver angle of 0o, 10o, 20o, 30o và 40o. The results obtained from the simulations show that increasing the louver angle results in rising the inlet air temperature of condensers and reducing COP. The average temperature of the air which entering the condensers does not change significantly when the louver angle increases from 0o to 30o. When the louver angle is more than 30o, the inlet air temperature of outdoor units exceeds the continuous operating temperature of 48oC. To maintain the high performance of the air conditioner during operation, the louver angle is adjusted as small as possible and limited to a value of about 30o.
Study of correlation between ink trapping and color difference in overprint
Authors:   Printing Material Lab, Faculty of Graphic Arts and Media, Ho Chi Minh City University of Technology and Education, Nguyen Thanh Phuong
Published: April 2023

The ink trapping value is one of the important parameters affecting the appearance of secondary colors in overprint. Usually, the ink trapping parameter is traditionally calculated based on the solid density values of the primary colors and the overprint color. These density values are measured by the complementary color filter of the color final ink layer, and these ink trapping values can be calculated using the Preucil, Ritz, or Brunner formulas. Furthermore, the density measurement is more suitable for testing the color printing and not for overlapping assessment because these density values are measured by the complementary color filter of the second color ink. The ink has a specific transmittance, and light is not only absorbed but also scattered inside the ink layer, so the total density of the overlapping colors will be less accurate. As a result, the color measurement method is used to describe the effect of ink trapping of the second ink layer on the first layer of ink. The main idea is to use the color difference value to evaluate the ink trapping ability. In this paper, the author has quantitatively analyzed the correlation between the percentage value of ink trapping and the color difference parameter ΔEab*. The studied results show that the ΔEab* value has a linear correlation with the ink trapping value calculated according to the traditional methods based on density values. This result is also aimed at the fluctuant tolerance of ink trapping ratio during four-color printing to achieve the standard color value quickly.
Investigating lactation curve characteristics of dairy cows
Authors: Kramarenko O. S.
Published: April 2023

The main goal of this study was to analysis of the main characteristics (latent variables) of lactation curve in dairy cows using multivariate Principal Component Analysis. This work used primary database from the milk production of Holstein cows (n = 238 heads) in the PJSC “Pedigree farm ‘Stepnoy’ Kamianka-Dniprovska Raion of Zaporizhzhia Oblast over a 4-yr period (2014-2017). Recording is done with an interval of 30 days for 10 test-days (TD1-TD10), i.e., TD1 is milk production recorded on milking day 30th, TD2 is day 60th, TD3 is day 90th, etc., and 305-day milk yield records (Y305) were used also. High significant correlations were found between daily milk yields for certain test-days. The Principal Component Analysis performed on the variance-correlation matrix of TD1-TD10 records are able to explain about 90.33 % of the total variance. The first principal component (PC1) explained 66.32 % of the total variance and was highly-positively correlated with TD2-TD10 records. Thus, PC1 were defined as “total milk production”. The second principal component (PC2) explained 19.06 % of the total variance and was highly-positively correlated with TD1-TD2 records and highly-negatively correlated with TD9-TD10 records.  Thus, PC2 were defined as “lactation curve persistency”. Finally, the third principal component (PC3) explained 4.95 % of the total variance and was highly-positively correlated with TD1 and TD10 records and highly-negatively correlated with TD4-TD5 records. Thus, PC3 were defined as “lactation curve type”. The use of a multivariate method (namely, the PCA) for the analysis of lactation curve characteristics based on monthly test-day records gave very close results of the analysis of milk productivity in different groups of domestic animals (cattle, goats and sheep). In all cases, the first principal component (PC1) described the absolute level of milk productivity during lactation, and the second principal component (PC2) described the persistency of the lactation curve. Significant influence on the PC1-PC3 factor scores was revealed to the greatest extent for such non-genetic factors as age of cow (in lactations), year and month of calving. Of the genetic factors, the greatest influence on the shape of the lactation curve was not so much the differences between the bull lines (Bell, Valiant, Elevation, Starbuck and Chief), but differences between individual bulls within some lines.
Toxicological characteristics of raw milk with different contents of 17β-estradiol
Authors: Kochetova Н. , Salata V. , Кukhtyn M. , Zghozinska O. , Melnyk V.
Published: April 2023

Despite the benefits and biological value of dairy products, they can also be a source of dangerous substances of natural and artificial origin. Such substances include the estrogen hormone 17β-estradiol, an excessive amount of which causes oncological diseases and reproductive system dysfunction. A study was conducted to determine the toxicological evaluation of raw milk with different 17β-estradiol content on the culture of the ciliate Tetrachymena pyriformis. The content of 17β-estradiol was determined by enzyme immunoassay using the RIDASCREEN®17β-őstradiol test system (Art-Biopharm/R-Biopharm, Darmstadt, Germany). During the determination of acute toxicity, under the condition of the content of 17ß-estradiol in the raw milk in the amount from 20.0 to 2500 pg/ml, no changes in motor activity, body shape and inhibition of reproduction of ciliates were observed. At the content of 17ß-estradiol in milk in the range of 5000.0−5500.0 pg/ml, a slowdown in the motor activity of ciliates was observed without changing the nature of the movement. Thus, the amount of 17ß-estradiol in milk greater than 5000.0 pg/ml causes a minor effect on the vital activity and motor activity of Tetrachymena pyriformis ciliates. During 96 hours of the existence of ciliates in milk, chronic toxic effects on cells were not observed for the content of 17ß-estradiol from 20.0 to 2500.0 pg/ml. Addition of 17ß-estradiol to raw milk in the amount of 5000.0 to 5500.0 pg/ml caused a chronic toxic effect on ciliates, as a result of which the total score in all determined indicators increased to 2 points. Thus, raw milk with an amount of 17ß-estradiol from 5000.0 to 5500.0 pg/ml may exhibit some chronic toxic effect on the cells of the ciliated infusoria. It was established that the relative biological value of raw milk with a content of 17ß-estradiol up to 2500.0 pg/ml was from 98.6 to 97.7 %, and in samples of raw milk with the maximum amount of the hormone (5000.0−5500.0 pg/ml) decreased by an average of 10 % to 89.22 %. Therefore, if the amount of 17ß-estradiol in milk is more than 5000.0 mg/ml, a chronic toxic effect on Tetrachymena pyriformis cells is possible.
Biochemical and mineral status of the body of infertile boars with hypovitaminosis A
Authors: Naumenko S. V. , Miroshnikova O. S. , Vikulina G. V.
Published: April 2023

A leading role in the occurrence of infertility in male domestic animals is played by nutritional deficiency factors, in particular vitamin A deficiency, which contributes to the development of morphological and functional changes in the reproductive system. The aim of the work was to determine the effect of vitamin A (carotene) deficiency on the biochemical and mineral status of infertile boars, in particular, to establish changes in the main biochemical markers and assess the state of the antioxidant defence system and indicators of mineral homeostasis (Calcium, Phosphorus, Zinc, Copper, Manganese and Cobalt). In the experimental group of animals, a probably low level of vitamin A was noted (by 54.2 % lower than the control group, P ˂ 0.001) due to a significant increase in the content of thiobarbiturate acid-reactive compounds (by 2.32 times, P ˂ 0.001) and a decrease in the activity of catalase and superoxide dismutase (by 47.3 % and 28.8 %, respectively, P ˂ 0.001). A decrease in haemoglobin concentration by 14.3 % (Р ˂ 0.001), total protein by 11.6 % (Р ˂ 0.01), the number of erythrocytes by 9.3 % (Р ˂ 0.01) and acid capacity by 9.1 % (Р ˂ 0.05). These results demonstrate a general decrease in metabolic processes in the body of infertile boars with vitamin A deficiency. The reduced number of erythrocytes in the blood of boars of the experimental group was mainly due to antiradical and antihypoxic abilities. It should be noted that catalase activity and the content of reduced glutathione in erythrocytes were probably lower than the control indicators by 53.1 % and 16.3 % (Р ˂ 0.001), respectively. In addition, taking into account the reduced indicators of haemoglobin content and the number of erythrocytes, a negative dynamics of oxygen metabolism was established. This is also confirmed by a probable increase in the content of 2,3-diphosphoglycerate in erythrocytes (by 67.5 %, Р ˂ 0.001). Also, in boars of the experimental group, the content of Calcium was lower by 25.0 % (Р ˂ 0.001) than the control indicators, and the content of Phosphorus decreased by 12.6 % (Р ˂ 0.05). Similar changes were observed in the levels of Zinc and Copper (indicators were lower than the control by 52.0 % and 28.0 %, respectively, Р ˂ 0.001). Note that the Manganese content in the blood of experimental boars was reduced by 20.9 % (Р ˂ 0.05), while the Cobalt level was lower by 16.1 % (Р ˂ 0.05). The obtained results showed a significant effect of A-vitamin deficiency on the general antioxidant activity and mineral homeostasis in barren boars.
ПІДГОТОВКА МАЙБУТНІХ УЧИТЕЛІВ ДО ВИКОРИСТАННЯ МЕТОДІВ КОМПЕТЕНТНІСНОГО НАВЧАННЯ РИТОРИКИ НА УРОКАХ УКРАЇНСЬКОЇ МОВИ
Authors: ГОРОШКІНА Олена , ГОЛУБ Ніна
Published: April 2023

У статті порушено проблему підготовки майбутніх учителів до використання методів компетентнісного навчання риторики на уроках української мови. З огляду на те, що одним із пріоритетних завдань учителя-предметника є формування в учнів низки наскрізних умінь та ключових компетентностей, з-поміж яких особливе місце посідає вільне володіння державною мовою, акцентовано на методах, що забезпечують формування компетентного мовця. Оскільки риторику здавна визнано як таку, що сприяє розв’язанню питань, пов’язаних з оволодінням секретами ефективної комунікації, законами ораторського мистецтва, постала потреба включення означеної дисципліни до навчальних планів закладів вищої педагогічної освіти. Однак освітня практика переконує, що студентам мало засвоїти питання теорії риторики, майстерне оволодіння мовою потребує комунікативного досвіду, напруженої системної роботи, наполегливості, формування критичного й логічного мислення, лінгвокреативності, опанування ефективним методичним інструментарієм, адже майбутні вчителі мають мотивувати здобувачів освіти до мовленнєвого вдосконалення, набуття суб’єктного досвіду. З огляду на зазначене важливо ознайомити їх із методами, що є складниками компетентнісно орієнтованої методики навчання риторики на уроках української мови. У статті акцентовано, що ознайомлення майбутніх учителів із методами, спроможними реалізувати завдання компетентнісного навчання риторики, має відбуватися на міждисциплінарних засадах. Це уможливлює різноаспектний розгляд проблеми сучасних методів компетентнісно орієнтованого навчання риторики в закладах загальної середньої освіти, що має відбуватися як у курсі методики, так і в процесі опанування риторики. Зазначено, що результатом міждисциплінарної підготовки може бути риторичне портфоліо студентів. Визначено дидактичний, розвивальний і виховний потенціал методів компетентнісного навчання риторики, представлено шляхи ознайомлення з ними вчителів-словесників, ідеї щодо використання їх в освітньому процесі. Розкрито роль та перспективи використання методів компетентнісного навчання риторики; визначено й схарактеризовано критерії добору їх та умови застосування. З’ясовано, що застосування методів компетентнісного навчання риторики сприяє підвищенню мотивації учнів і учениць до навчання української мови, послуговування нею в будь-яких життєвих ситуаціях, здатності до толерантного та ефективного спілкування.
SOCIAL ORIENTATION OF THE MARKET ECONOMY OF UKRAINE AS A FACTOR OF INCREASING NATIONAL COMPETITIVENESS
Authors: Moskvina A.
Published: April 2023

The article shows that the effectiveness of the system depends on the effective interaction of social and economic components of development, and in the conditions of consolidated interaction of social and economic factors, the development processacquires long-term stability and dynamism. It is proved that ensuring a commensurate complementarity of the social and economic components of national development as an important mechanism for improving the competitiveness of the country should become thetarget of the state development strategy, and the need for the formation of a socially-oriented market economy in Ukraine for the implementation of the planned goals is revealed. The development of a socially oriented market economy in Ukraine will build the necessary system of values, improve the culture of doing business, social and economic efficiency, create a strong system of social protection of the population, form the optimal directions of sustainable development of the country. Achieving the set parameters requires harmonization, ensuring the complementary unity of the social and economic components of the national policy, which implies the formation of additional transmission channels of close interaction between the social and economic subsystemsof society, aimed at the overall results of improving the national competitiveness of the country.In a socially-oriented economy, in addition to achieving macroeconomic goals, the state also has social goals, and its economic activity is aimed at eliminating the imperfection of the market, giving it a social orientation. The participation of the state in a socially oriented market economy is carried out through state regulation, which is aimed at achieving such goals as creating normal conditions for the functioning of the market mechanism, ensuring sustainable growth rates, regulating structural changes in the economy on the basis of priority production of socially important products, ensuring social justice in the distribution of income, social stabilityand social progress, creating a favorable human environment and solving environmental problems.Keywords:market, social economy, social orientation, potential, regulation, factors, competitiveness, policy.
ANALYSIS OF WAYS TO INCREASE THE EFFICIENCY OF COMPRESSED AIR FOAM FOR EXTINGUISHING SOLID MATERIALS
Authors: Shakhov S. , Vinogradov S. , Grishenko D.
Published: April 2023

Conduct an analysis of scientific periodicals regarding the use and improvement of the fire extinguishing efficiency of compression foam. The work was carried out on the basis of the analysis of scientific periodicals, experimental studies of scientists from the European Union, the USA, China and other countries, the results of which were presented in scientific publications, conferences and reports. Conclusions. An analysis of scientific publications devoted to the use of compression foam in firefighting and increasing its fire-fighting efficiency was carried out. It was found that the majority of research is aimed at studying the fire-extinguishing effectiveness of compression foam when extinguishing flammable liquids. In turn, there are studies devoted to increasing the fire-fighting efficiency of compression foam by varying the multiplicity and concentration of the aqueous solution of the foaming agent, changing the ratio of air/foaming agent solution, and the use of various types of foaming agents when extinguishing fires of solid combustible materials. To date, there are no studies aimed at increasing the efficiency of compression foam by adding modified additives to its composition. The result of the research is the identification of ways to increase the efficiency of compression foam today, due to which the direction of further research aimed at increasing the fire-extinguishing efficiency of the foam in other ways is revealed. The practical value lies in solving the actual problem of fire safety, namely increasing the efficiency of extinguishing fires of solid combustible substances, due to the use of compression foam. Thanks to the results of the analysis of further development, effective use of compression foam is acquired, the fire-extinguishing capacity of which can be increased by using modified additives in its composition. This provides an opportunity to expand the mechanisms of influence of the fire-extinguishing effect of compression foam on the burning process of solid combustible materials.
Keywords: modified additives, compressed air foam, fire extinguishing, civil safety, fire safety.
CHARACTERISTICS OF FACILITIES OF CRITICAL STATE INFRASTRUCTURE (FEATURES OF NUCLEAR AND OTHER STRATEGIC FACILITIES)
Authors: Azarenko O. , Honcharenko Yu. , Divizinyuk M. , Shevchenko R. , Shevchenko O.
Published: April 2023

The work defines the objects of the state's critical infrastructure, their relationship with strategic and other dangerous objects and productions. It should be noted that today Ukraine, as a state that defends its independence in the war, faces many different tasks, one of which is the protection of critical infrastructure objects from military-terrorist influence, the solution of which not only saves the lives of civilians, but also ensures the defense of sovereignty, territorial integrity and independent existence of the state. The solution of this task is carried out both in wartime and in peacetime. The problem is to determine the objects of the state's critical infrastructure, in their correlation with strategic and other dangerous objects and productions, which in practice allows determining the priority of their protection in terms of the involvement of technical and material means.
Based on the above, the purpose of this article is to determine the relationship between the terms critical infrastructure object, potentially dangerous object, dangerous production object and strategic object, from the standpoint of ensuring their security and countering terrorist threats.
The concept of state infrastructure and the process of formation of the term critical infrastructure of the state are considered. The characteristics of the objects of strategic purpose are given. The meaning of the concepts of potentially dangerous, dangerous industrial and critically important objects is analyzed.
It is proved that based on the assessment of the constituent parts of the state's critical infrastructure, the concepts of a potentially dangerous object, an object of hazardous production, a critically important object and a strategic object can be considered identical in relation to nuclear objects.
Prolonging the reasoning in this way, it is possible to confirm the validity of this identity in relation to other objects of critical infrastructure, for example, hydro and thermal power, petrochemicals and others.
Keywords: critical infrastructure object, nuclear object, terror, dangerous object, protection, concept.
REQUIREMENTS FOR HAZARD ANALYSIS MODELS AND CALCULATIONS DEGREE OF RISK
Authors: Bogatov O. , Zaichenko V. , Bilym P. , Rogozin A.
Published: April 2023

Based on statistical data, the main reasons for the low level of labor protection organization in Ukraine are formulated. In recent years, there has been a sharp increase in cases of industrial injuries. UAH 334 million was spent on monthly insurance payments to families who lost breadwinners. for temporary incapacity for work due to an accident or occupational disease - UAH 138.1 million. The data presented in the article indicate that the main causes of fatal accidents are organizational, psychophysical, technogenic, and technical. The main reasons for the low level of labor protection organization in Ukraine are given by the authors, who say that in today's conditions, the labor protection management system should be based not only on measures from the state, but also on the interest of the subjects of labor relations in maintaining the proper physical condition of the employee.
A real health risk assessment is impossible without a sufficient information base on the quantitative and qualitative characteristics of risk factors and data on the health status of those contingents of the population that are exposed to these factors. The effect of potentiating with the combined influence of professional and non-professional factors has been established. Therefore, there was a need to develop new methods of analysis and modeling of the conditional probability of the occurrence of an industrial injury, acceptable for practical engineering calculations. The proposed indicators of the level of ensuring the safety of people at the objects are the probability of preventing exposure to dangerous factors of the production environment and work process, which can be determined by the full risk of an accident.
Thus, on the basis of the application of the probabilistic method for modeling the conditional probability of injury to an employee during technological operations, an assessment of the probability of an accident and the development of various variants of dangerous situations was carried out. This will make it possible to get an assessment of the circumstances and conditions that contribute to the occurrence and development of traumatic situations at work.
Keywords: labor protection, occupational injuries, industrial environment, accident, risk, danger, harmfulness, probability.