bluuebunny/crossref_metadata_2025 huggingface dataset:
Establishment of a human induced pluripotent stem cell neuronal model for identification of modulators of A53T α-synuclein levels and aggregation
Authors: Vajhøj Charlotte , Schmid Benjamin , Alik Ania , Melki Ronald , Fog Karina , Holst Bjørn , Stummann Tina Charlotte
Published: December 2021

Inhibiting formation or promoting degradation of α-synuclein aggregates are among the therapeutical approaches under investigation as disease-modifying treatment strategies for Parkinson’s disease. To support these developments, several in vitro models based on seeded α-synuclein aggregation have been established in immortalized cell lines and murine primary neurons. Here, we report on a humanized model with a reproducibility and throughput that enables its use in supporting target identification and validation in pharmacological research. A human induced pluripotent stem cell (iPSC) line was genetically modified to express HA-tagged α-synuclein with the point mutation in position 53 from Alanine to Threonine (A53T) under an inducible system and differentiated into cortical neurons expressing neuronal markers and exhibiting spontaneous activity. Intracellular α-synuclein aggregation was triggered by exposure to exogenous added fibrillated recombinant wild-type human α-synuclein fibrils91 and demonstrated by several endpoints; the formation of Triton-insoluble SDS-soluble α-synuclein, biochemically in a fluorescence resonance energy transfer based aggregation assay and by immunocytochemistry of phosphorylated α-synuclein positive puncta. We demonstrate the feasibility of upscaling the iPSC neuron production for drug discovery and that the model has a suitable dynamic range allowing for both detection of increased and decreased α-synuclein aggregation. Moreover, gene modulation is feasible using siRNAs, making the model suitable for genetic screening for modulators of α-synuclein aggregation. Data on effects of USP8, USP13 and USP9X knockdown on α-synuclein expression and aggregation contradicts published data from immortalized cell lines and murine systems. This highlight the importance of including humanized neuronal models in the confirmation of biological mechanisms in specific variations of Parkinson’s disease.
DHEA and polycystic ovarian syndrome: Meta-analysis of case-control studies
Authors: Benjamin Jiby Jolly , K. MaheshKumar , Koshy Teena , K. N. Maruthy , R. Padmavathi
Published: December 2021

Background

Polycystic ovarian syndrome is a heterogenous endocrine disorder characterized by irregular menstrual cycles, hirsuitism and polycystic ovaries. It is further complicated by metabolic syndrome, infertility and psychological stress. Although the etiopathogenesis is unclear, many studies have pointed out the role of stress in this syndrome. DHEA, being a stress marker is being used by scientists to compare the stress levels between polycystic ovarian cases and healthy controls. However, the results obtained from previous studies are equivocal.

Objective

To perform meta-analysis and find the association between stress and the syndrome.

Data sources

Relevant data till January 2021 were retrieved from PubMed, Scopus, Embase and Web of Science using MeSH terms.

Study selection

Case-control studies having PCOS subjects as cases and healthy women as controls were selected provided; their basal DHEA levels were mentioned in the published articles.

Data extraction

Two authors independently extracted the articles and qualified the final studies.

Data synthesi

Pooled meta-analysis was done using random effect model and showed level of DHEA statistically significant in PCOS compared to healthy controls (SMD = 1.15, 95% CI = 0.59–1.71).Heterogeneity was statistically significant as well (I2 = 95%).

Conclusion

Thismeta-analysis on DHEA and PCOS has helped in generating evidence regarding the involvement of stress in the pathogenesis of PCOS.
La Renta básica universal: propuestas para un derecho “por venir”
Authors: Soler Tormo Francisco
Published: December 2021

La Renta Básica Universal es una prestación monetaria que se concede a todos los ciudadanos de un territorio, sin ningún requisito específico. Se trata, con ello, de garantizar que todas las personas dispongan de unos ingresos suficientes para cubrir las necesidades esenciales de la vida. En este sentido, en esta propuesta confluyen elementos que definen los sistemas económicos y sociales, como la justicia, la equidad, la dignidad de todos los ciudadanos o la eficiencia productiva.La creciente digitalización y robotización del sistema productivo, la automatización de los puestos de trabajo y la pérdida acelerada de empleo generan dos efectos inmediatos: un aumento extraordinario de la productividad y la persistencia de un elevado desempleo estructural. Como consecuencia, se acentúa la distribución desigual de la renta y la riqueza y se multiplica el riesgo de exclusión social y de pobreza extrema.
New Data in the Research of Settlements of the Saka Time in Central Kazakhstan
Authors:   “Begazy-Tasmola” Research Center of History and Archaeology, A. Beisenov
Published: December 2021

The article is devoted to an overview of the results of new studies of the Saka era settlements discovered in the eastern regions of Central Kazakhstan. The source base of modern research was made up of over 70 settlements found over the past 20 years. The author attributes these settlements to the tasmola culture of Central Kazakhstan and dates them within the framework of the 8th — 5th centuries BC. Archaeozoological, traceological, and carpological analyzes are being carried out based on the materials from the excavations of the Kulzhan-1 and Abylai settlements and other sites carried out in recent years. According to the author, the settlements of Central Kazakhstan of the Saka era were the winter habitats of the tribes of the Tasmola culture. Materials from over 50 Kazakh wintering sites make it possible to draw ethnographic data. A comparative study of these sites has shown that the topography of the Kazakh wintering grounds and Saka settlements coincide. Keywords: Central Kazakhstan, tasmola culture, Saka era, settlements, Kazakh wintering grounds, multidisciplinary research
Iskolázottsági és keresetegyenlőtlenségek : Educational attainment inequalities and earnings inequalities
Authors: Polónyi István
Published: December 2021

Az iskolázottság növekedése az előrejelzések szerint nem lassul. Ugyanakkor az iskolázottság növekedésével az iskolázottsági egyenlőtlenségek alakulása sajátos képet mutat. Az iskolázottság növekedésével az iskolázottsági egyenlőtlenségek a Kuznets-görbének nagyjából megfelelő lefutást mutatnak a magasabb iskolázottság időszakában, de az országcsoportok nagy részében ez kiegészül egy ellentétes görbületű résszel az alacsonyabb iskolázottság időszakában, s így egy hullámszerű alakulás jellemzi az iskolázottsági egyenlőtlenségeket az iskolázottsággal együtt vizsgálva. Az írás azt is megvizsgálja, hogy az iskolázottsági egyenlőtlenségek milyen kapcsolatot mutatnak a keresetegyenlőtlenségekkel.Educational attainment is growing and is not projected to slow down in the future. However, as educational attainment rises, the evolution of educational inequalities shows a particular pattern. As schooling increases, the inequalities in schooling follow a roughly Kuznets curve slope for the period with a higher number of years of schooling completed. But in most groups of countries, this is complemented by an opposite curvature in the period of lower education, and thus a wave-like trend characterizes educational inequalities when examined in conjunction with education. In addition to analysing educational inequalities, the paper also examines the relationship between educational inequalities and earnings inequalities.
Az innovációs ökoszisztéma-kutatások növekvő fontossága : A téma tudománymetriai elemzése
Authors: Horváth Klaudia Gabriella
Published: December 2021

Az innovációs együttműködések mozgatórugóinak megértése és az ismeretek gyakorlati hasznosítása elengedhetetlen a versenyképességgel és általános gazdasági fejlődés lehetőségeivel foglalkozó kutatók és gyakorlati döntéshozók számára. Ezzel összefüggésben jelen tanulmány rövid áttekintést ad az innovációs ökoszisztéma-fogalom koncepcionális kereteiről, illetve az innovációs együttműködések szerepéről az innovációs folyamatokban. Az elméleti megalapozás mellett a tanulmány fő célkitűzése, hogy leíró statisztikai módszerekkel, a Scopus adatbázisának segítségével azonosítsa azokat a trendeket, szerzőket és periodikákat, amelyek ismerete a témát Magyarországon vizsgáló kutatók és döntéshozók számára elengedhetetlen a világgazdaságban megfigyelhető tendenciák megértéséhez és a nemzetközi diskurzusba való bekapcsolódáshoz. Understanding the driving force of innovation cooperations is an essential element for both researchers and decision-makers in connection with competitiveness and economic development. In this context, this study provides a brief overview of the conceptual framework of innovation ecosystem and the role of innovation cooperations in innovation processes. In addition to the theoretical foundation, the main objective of the study is to identify the major trends, authors and journals of innovation ecosystem research based on Scopus database. The science metrics thus provide a solid summary of the topic for readers and „best practices” for a consistent publication strategy for researchers.
Erkölcsfilozófia és közgazdaságtan
Authors: Szabó Dorottya
Published: December 2021

A 21. században a társadalmi-gazdasági rendszereink olyan problémákkal néznek szembe, melyek megoldásához egy új, egységes elméleti keretrendszer szükséges nemcsak az egyes tudományágak viszonylatában, hanem interdiszciplináris szinten. Ezen közös keretrendszer kialakítása nem pusztán az ismereteink cseréjét jelenti, hanem a diszciplínák együttműködését és kölcsönhatásaik által való fejlődésüket igényli. A következőkben arra teszek kísérletet, hogy nagyon röviden rámutassak a közgazdaságtan és az erkölcsfilozófia kapcsolatára, illetve ezen tudományágak jelenleg érzékelhető, közös fordulópontjára elsősorban Micheal Sandel és Mariana Mazzucato munkásságának bemutatásának segítségével.
A globalizáció jövője a koronavírus-válság árnyékában : Harold James: „Globalization’s Coming Golden Age –Why Crisis Ends in Connection”. Foreign Affairs, 100(3), 20212
Authors: Málits Péter
Published: December 2021

Harold James a Foreign Affairs folyóiratban publikált dolgozatában amellett érvel, hogy bár a koronavírus-válság a laikus szemlélő számára a globalizációt ért végzetes csapásnak tűnhet, valójában egy fellendülési szakasz várható. Ehhez történelmi párhuzamokat von az 1840-es, illetve 1970-es évek válságaival. Mindezek alapján igazoltnak látja azt a tézist, miszerint a mély krízisek végeredményben a globalizáció erősödéséhez vezetnek. In his publication in Foreign Affairs, Harold James uses historical parallels from the 1840s and 1970s to demonstrate that even though the effects of the coronavirus crisis on globalization seems to be deeply destructive, it will roar back very soon. He argues that globalization follows a cyclical pattern in which increasing integration is followed by backlashes and crises, and history shows that crises often produce more globalization.
Is interleukin 6 measurement in exhaled breath of COVID-19 and post-COVID-19 lung fibrosis patients easy, sensitive and useful indicator of intensity of airway inflammation and fibrosis?
Authors: Ahmed Amr Kamel Khalil , El Kazzaz Mahmoud
Published: December 2021

COVID-19 has emerged as a global pandemic. It mainly manifests as pneumonia, which may deteriorate into severe respiratory failure. The major hallmark of the disease is the systemic inflammatory immune response characterized by cytokine storm (CS). CS is marked by elevated levels of inflammatory cytokines, mainly interleukin-6 (IL-6), IL-8, IL-10, tumor necrosis factor-α (TNF-α) and interferon-γ (IFNγ). Of these, IL-6 is found to be significantly associated with higher mortality. IL-6 is also a robust marker for predicting disease prognosis and deterioration of the clinical profile. (1) IL-6 was detectable in the breath condensate of all healthy nonsmokers but was significantly higher in COPD patients. Exhaled breath condensate is totally noninvasive and highly acceptable to patients. The collection procedure has no effect on airway function or inflammation, and there is growing evidence that abnormalities in condensate composition may reflect biochemical changes in airway lining fluid. This method has been successfully used in previous studies to investigate several inflammatory markers in COPD and asthmatic patients. (2) Il-6 is produced in the lung by interstitial fibroblasts, alveolar macrophages, and large-vessel and bronchial epithelial cells.These studies and our novel method after clinical trials may open the field for future therapies for COVID-19 and post-COVID-19 lung fibrosis by inhaler transport medicines as a new challenge for overcoming sequelae of this pandemic. This suggested a new procedure for the measurement of exhaled IL-6. We studied which IL-6 is risky is IL-6 produced from airway or endocrine IL-6 or immune IL-6. We can classify IL-6 as cytokine storm under pathological conditions to three mains of sources as immune IL-6 produced from respiratory system like interstitial fibroblasts and bronchial epithelial cells and fibroblast, second endocrine IL-6 produced from zona glomerulosa of adrenal glands stimulated by ACTH and immune IL-6 from macrophages and other immune cells. From previous studies we need a procedure acceptable to patients and easy, noninvasive, sensitive so we plan for clinical trial registered at clinicaltrials.gov about measurement of interleukin-6 at exhaled condensate of covid-19 patients and post-19 covid patients with lung fibrosis as a novel study which may be a useful tool, easy, sensitive for early intervention with anti-il6 medications and determine the degree of severity by inflammatory markers for intensity of airway inflammation.
Serverless Architecture For Bulk Email Management
Authors: Bazaru Priyatham Sai Chand
Published: December 2021

Email sending is an important tool to broadcast messages to many people to convey information. bulkemails in magnitude of thousands of emails is needed for large organization or company reaching outto its customers.Creating and maintaining a server to accomplish this is not only time-taking but notcost-effective. Products such as Gmail and Outlook are useful in basic emailing services but fail to beuseful in larger volumes of emails to target people or spread information to consented individuals.Thispaper tries to achieve bulk email management throught the use of serverless architecture to sendemails through a service from the Amazon Web Services(AWS) ecosystem.
Uso de medicamentos potencialmente inapropriados para idosos em uma instituição de longa permanência
Authors: Rosa Luana Pereira , Dal Bó Silvia
Published: December 2021

Vivemos uma mudança no perfil demográfico, o decrescimento da média de filhos por mulher, em contraponto com o aumento da expectativa de vida. Em um futuro próximo, uma grande parcela da população será composta por idosos. Este fato acarreta um problema de saúde pública, necessitando de um olhar cauteloso em relação a proteção e promoção da saúde do idoso. Sabe-se que com o passar dos anos a população tende a apresentar patologias características da idade, resultando em pacientes polimedicados e/ou fazendo uso de medicamentos inapropriados. O objetivo dessa pesquisa foi avaliar as prescrições de 35 pacientes idosos residentes em uma instituição de longa permanência no Extremo Sul Catarinense, identificando o uso de medicamentos inapropriados conforme Critério de Beers e Start/Stop, além de pontuar possíveis interações medicamentosas. Com base nos dados obtidos, pode-se afirmar que 60% dos indivíduos são do sexo feminino, a maioria com idade entre 66 e 85 anos; 6% são portadores de polipatologias e 66% em uso de 5 a 10 medicamentos. Dos medicamentos utilizados 30% são inapropriados para idosos e 216 interações medicamentosas foram encontradas, destas, 91% tratam-se de interações moderadas e 9% de interações graves. A pesquisa possibilitou chamar a atenção dos profissionais de saúde demonstrando números elevados em relação a interações e uso de medicamentos impróprios, além de relatar o impacto dessa realidade e seus agravos na qualidade de vida do idoso.
Estado nutricional y factores de riesgo cardiovascular en estudiantes ingresantes de la Universidad Nacional del Litoral en el período 2006-2019
Authors: Gambuzza A. G. , Gottig A. N. , Negro E. , Gesualdo S. S.
Published: December 2021

La detección de los factores de riesgo cardiovascular (FRCV) en adultos jóvenes adquiere especial relevancia, porque permite identificar su vulnerabilidad y contribuye a focalizar estrategias de prevención. El objetivo del presente trabajo fue evaluar el estado nutricional y FRCV en estudiantes ingresantes de la Universidad Nacional del Litoral (UNL), en el período 2006-2019. Para ello, se planteó un estudio descriptivo–retrospectivo con una muestra total de 1481 historias clínicas seleccionadas al azar, distribuidas por año y desglosadas por sexo. La condición más prevalente fue “peso normal”, seguido por el “sobrepeso” y la “obesidad”. La prevalencia de “exceso de peso” entre 2006-2019 mostró una tendencia ascendente, mientras que el “peso normal” disminuyó en el mismo período de tiempo. Luego del “exceso de peso”, el FRCV más prevalente fue la “hipercolesterolemia” seguido por la “presión arterial alterada” y por último la “glucemia alterada”. Una comparación entre los años 2006 y 2019 evidenció un aumento de estudiantes con la presencia de “uno o más FRCV”. Estas diferencias no fueron significativas. Por todo lo anterior, resulta indispensable diseñar e implementar estrategias para promover cambios de estilo de vida en jóvenes y prevenir enfermedades cardiovasculares en la edad adulta
Estudio de carga de fuego y protección contra incendios en una empresa de nutrición y sanidad animal
Authors: Rodríguez M. A.
Published: December 2021

Se define carga de fuego como el peso en madera por unidad de superficie (Kg. /m2), capaz de desarrollar una cantidad de calor por combustión equivalente a la de los materiales contenidos en el sector de incendio sometido a estudio. En esta investigación se realizó el cálculo de carga de fuego en facyt SRL, una empresa dedicada a la elaboración de productos de nutrición y sanidad animal, donde encontraremos materiales específicos de su actividad, tales como materias primas de núcleos vitamínicos y fármacos, de ésta manera se pretende sentar antecedentes para futuras investigaciones en empresas del mismo rubro o similares. Una vez obtenida la carga de fuego, se le asignó a los combustibles registrados el riesgo correspondiente y se identificó el potencial extintor para los matafuegos, así como la resistencia al fuego esperada para los elementos constitutivos del edificio. Se determinó que clase de extintores deberían estar presentes, la distribución que los mismos deberían tener y tanto la cantidad como el ancho de salida de los medios de escape necesarios. Una vez terminados los cálculos se obtuvieron las conclusiones correspondientes.
Incidencia del juego como recurso didáctico en los procesos de enseñanza y aprendizaje de las Ciencias Naturales
Authors: Altamirano Facino A. B.
Published: December 2021

En la presente investigación se ha indagado sobre la aplicación de actividades lúdicas en el aula que fomenten el aprendizaje significativo de los alumnos. Esta investigación es de corte cuali-cuantitativo y etnográfico. Se encuentra orientada hacia un enfoque socio-antropológico y, en efecto, pretende adentrarse en un territorio determinado que, dado el caso, se trata del aula de clases. Asimismo, se trata de una investigación de tipo descriptiva-explicativa. Consistió en la realización de encuestas a los estudiantes y una entrevista que se planteó a la docente. Dichos instrumentos de recolección de datos denotaron que la aplicación de juegos didácticos en el aula funciona como un elemento fehaciente para promover el aprendizaje significativo de los alumnos en la clase de Ciencias Naturales.
Historia, temporalidad y ficción. Los 70’s a través de la literatura, una aproximación a “Vivir Afuera” de Fogwill y “Los Planetas" de Chejfec
Authors: Seminara Luciana
Published: December 2021

El objeto de este texto está constituido por una serie de representaciones literarias producidas en el arco temporal de los años noventa en la Argentina. Siendo de particular interés los modos ficcionales de narrar la vida cotidiana, la memoria y, el espacio urbano en dictadura (1976-1983). Desde esa posición se busca explorar la construcción de historicidad y cifrar ciertas configuraciones de la memoria social emergentes en ese determinado contexto. Cómo y de qué manera puede pensarse la relación entre representaciones literarias, historicidad y memoria(s) en el contexto post dictatorial y más específicamente en la década del noventa en la Argentina.
Reseña de Pérez Cáceres, Carlos. Dictadura y Memoria. Tomo III, Asunción
Authors: Montero Mariano Damián
Published: December 2021

A través de treinta entrevistas a diferentes actores que integraron variados colectivos políticos que se enfrentaron a la dictadura de Stroessner, desde 1954 en sus inicios hasta su final en 1989; el investigador paraguayo Carlos Pérez Cáceres, nos ofrece en este tercer tomo de la serie Dictadura y Memoria, una muestra de lo complejo y diverso que fueron las manifestaciones de oposición al stronismo, desde los intentos armados hasta las luchas dentro del sistema.
Sobre los mitos del Rey Arturo y de la magia
Authors: Ramos Vera Mario
Published: December 2021

Los ensayistas y literatos C. S. Lewis y Charles Williams recogieron la Materia de Bretaña, con su valor mítico, y lo plasmaron dualmente a través de las leyendas artúricas y la categorización de la magia a través de la división convencional entre magia blanca y magia negra. En este último supuesto, respetaron la división propia de los mitos de las artes mágicas entre teúrgia y goetia —magia natural y magia demoníaca— en continuidad con los planteamientos de la renacentista Academia Platónica de Florencia. Esta recepción del mito aparece nítidamente en las obras de C. S. Lewis, Esa horrible fortaleza, y de Charles Williams, Guerra en el cielo. Se trata de marcos de ficción, donde realizan un ejercicio mitopoético que vincula los mitos artúricos y mágicos para responder desde un fundamento metafísico y trascendente a preguntas perennes de la condición humana.
Zofío. Haciendo frente a la COVID-19 en red en un barrio
Authors: Ortuño Torres José , Jiménez Jiménez José Antonio
Published: December 2021

Previamente a la pandemia de COVID-19, la situación social de la comunidad de Madrid no estaba en correlación directa a su situación económica. entre otros hechos, hay que destacar que la desigualdad era la más alta de España (FOESSA, 2019), a esto, había que sumar la precaria situación de los servicios sociales en la comunidad de Madrid (AEDGSS, 2019). la pandemia no ha hecho sino agravar la situación social de numerosos vecinos y vecinas de Madrid, y sobrecargar la red pública de servicios sociales. Pero puso también de manifiesto, la capacidad de solidaridad y respuesta a los problemas sociales causados por la COVID-19 de las asociaciones de vecinos de diferentes barrios de la ciudad, siguiendo su larga trayectoria en defensa de la democracia, la vivienda o los equipamientos. Un ejemplo de la colaboración entre administraciones públicas, tercer sector y movimiento vecinal lo encontramos en el barrio de Zofío, del distrito de Usera (Madrid), en el reparto de alimentos durante el confinamiento. Esta experiencia nos lleva a preguntarnos si, en la solución de los problemas sociales que afronta la sociedad madrileña, se han explorado suficientemente las vías que ofrece el trabajo comunitario entre administraciones públicas, tercer sector y movimiento vecinal.
Weaning in der neurologischen Frührehabilitation (NFR)
Authors: Rollnik J. D.
Published: December 2021

Weaning in neurological early rehabilitation represents an important participation goal that can be achieved in up to 90% of cases after an average of two to three weeks of weaning through a combination of intensive care and rehabilitative interventions. The weaning process should be based on a standardized weaning protocol, with which a gradual expansion of spontaneous breathing phases can be achieved. The German Society for Neurorehabilitation (DGNR) has taken the special features of prolonged weaning in NFR into account in a separate guideline.
Implementasi Quick Response (QR) Code Pada Dokumen Instruksi Kerja Alat Laboratorium Kimia
Authors: Wangsa W , Prastyo P
Published: December 2021

Work instructions laboratory equipment is one of the documents that must be available in the laboratory. This document provides information on the operation steps of the device correctly. A laboratory manager usually prints the document on A4 size paper and installs it on a part of the tool to facilitate access to the document. The treatment makes the work instruction document break down quickly and is not suitable to be applied to small sized tools. Therefore, it is necessary to manage the work instruction document for easy access, efficiency in the use of documents, and to improve the security of document storage. In this case, the QR Code can be used as a solution to the problem. QR Code is able to store documents and URL links in a small barcode image so that it can be use more efficient. Making a QR Code is preceded by storing documents at https://drive.google.com. The URL link at https://drive.google.com is entered into the QR-Code Studio 1.0 application and converted into a barcode. Barcodes are then printed and installed on each laboratory instrument. Scanning QR Code using a smartphone application in the form of a QR-Code Scanner. The results of the barcode scanned are the form of scripts for laboratory work instructions
Perbandingan Modifikasi Bentuk Lambung Terhadap Tahanan Kapal Menggunakan Metode "Delftship"
Authors: Cahyo Indro Dwi
Published: December 2021

This study aims to analyze the resistance on vessels that have a single hull shape of the hard-chine type is modified to a multi-chine types using the "DELFTShip" method. This research includes research on the development of the "DELFTShip" method using a speedboat sample of the Vocational School - Undip, where the ship plans to be modified on the hull that was originally hard-chine to multi-chine, with a qualitative approach using the "DELFShip version 4.03.68" method which can later be known differences in the value of ship resistance (RT).Results showed that the resistance value (RT) at a speed of 3 knots there is a difference -0.0332 kN, at a speed of 4 knots there is a difference of 0.0925 kN, and at a speed of 5 knots there is a difference 0.3205. By referring to the number of Froude Number. , stomach with multi-chine type has the value of prisoner (RT) is better than the stomach with hard-chine type.
Pembuatan Teskit Boraks dalam Upaya Efisiensi Penggunaan Bahan dan Alat Laboratorium
Authors: Sulistyawati S , Wiyati Widyaningsih
Published: December 2021

Borax is a carcinogenic compound which is dangerous to the body. The flame method is one of the qualitative laboratory testing that usually used to determine the Borax compound in food. The method not only needs H2SO4, methanol, furnace equipment which is prices, but also needs long time because of the graying process. The research aims to make a simple borax test kit (simple method) by extracting anthocyanin substances on the skin of purple sweet potatoes and testing the borax compound in food samples. Materials and tools used are purple sweet potato skin, 96% ethanol, filter paper, knives, cutting boards, measuring cups, beaker glass, food scales and petri dishes. The results of the borax test kit that have been made are then tested using the borax standard as the gold standard and it showed that there was color changing of the test kit, i.e from pink to blue. The borax test kit was also tested on four food samples that possibly contained borax, i.e gendar crackers, white tofu, meatballs and noodles. Gendar crackers was the only food sample that contain borax. Therefore, it was concluded that the borax test kit made from filter paper containing anthocyanin can be used as an alternative tool in qualitatively testing of borax in food
Pemanfaatan Sampah Bahan Habis Pakai Non-Medis Laboratorium Ketrampilan Klinik (SKILLS LAB) Sebagai Modifikasi Alat Peraga Sederhana Skill Mandiri
Authors: Patmawati P , Hidayati Fadilah
Published: December 2021

The Skills Lab is a facility where students can practice the skills they need, which is not a real context between doctor and patient. Practicum in the Clinical Skills Laboratory and OSCE uses non-infectious non-medical consumables. The stages of making modification props are carried out in several stages including: collecting and sorting non-infectious non-medical consumables. Disinfection of non-medical consumables that are non-infectious with antiseptics. The produced props include gloves used as prepuce in circumcision beads. Modified infusion plastic bottles resemble human nails we use for nail extraction skills. The IV line can be modified as a vein in the bead, this is used for the sexy vein skill in the beaded IV. Abocart needle (neddle) is used for NGT or usually called sonde for experimental animals. Rubber infusion hose is used as an LED tube rubber ball in Clinical Pathology practicum.
Perancangan Klem Untuk Cetakan Vertical Pouring Di Laboratorium Pengecoran Logam Politeknik Manufaktur Bandung
Authors: Solihin Mohamad Agus , Suhada Dodo , Sukiman S
Published: December 2021

In the foundry laboratory at Bandung Polytechnic for Manufacturing, there is a student practicum program where the student learns several molding methods that are often used. One of these methods is a vertical pouring method. This is a one of mold method in the foundry process where the object is positioned vertically (vertically) with the inlet position either at the bottom of the object or at the top of the object. In this experiment using the vertical pouring method with direct pouring from a top. This method is usually used for objects that are plate shaped or cylindrical. The advantage of this method can control shrinkage and minimizes the mold area. In the process, where the object will be made in limited quantities, the mold is tied and buried in sand. The problems are processing time is longer than Cup and Drug molds, and wears a lot of sand. For this reason, a tool for clamping vertical molds is designed. This tool is expected to reduce use of sand, and reduce processing time. This tool is made of steel. vertical pouring method becomes more effective and efficient by using clamps
Charakterystyka wczesnej reklamy pandemicznej
Authors: Kowalewska Kinga
Published: December 2021

The aim of this paper is to examine early pandemic commercials and show the main changes in their focus from the point of view of communication. In terms of the contents, COVID-19 lockdown, heroism of health care workers, social distancing, online learning, remote work, and the strong shift towards online communication are underlined with an enormous stress put on such values as family, helping each other and being together in these difficult times. Characteristic nonverbal components of commercials referring to the pandemic situation include, for example, sentimental piano music, dimmed colours, a specific style of filming, or showing ordinary people as actors. Finally, it is noticed that some ad makers decide to use the sense of humour in their spots. In conclusion, the coronavirus pandemic and its effects can be easily observed on every level of an advertising message.
Questioning North Korea’s digraphic inflection point: Kim Il Sung’s 1964 and 1966 conversations with linguists reconsidered
Authors: Strnad William
Published: December 2021

Kim Il Sung’s 1964 and 1966 conversations with linguists are appropriately deemed important as the establishment of the North’s “cultured language” as a standard, as well as guidance related to language purification and script. In the analysis of inflection point related to language planning and policy in the North, is the often guidance on re-enshrinement of teaching “Chinese characters” (hanja) in North Korean education. Clearly this was official pronouncement of functional, synchronic digraphia, which has been preserved and operationalized down to the present. Scholarship on these conversations, amounting to policy guidance, attribute the shift in policy related to script as an inflection point. The author of this article concurs with its importance, but with respect to digraphia in the North, the conversations related to hanja instruction served as a confirmation for what was a broad trend in North Korean language planning during the years 1953-1964, a language planning and policy  fait accompli, diminishing the portrayal of the conversations as a digraphic inflection point in North Korea.
Positional modeling of the 2T6R robot mechanism
Authors: Comanescu Adriana , Rotaru Alexandra , Ungureanu Liviu Marian , Petrescu Florian Ion Tiberiu
Published: December 2021

The positional modeling of the 2T6R robot mechanism is done for inverse kinematics, i.e. when the imposed positions of the end effector T, imposed, belonging to the final element 3, are known and the necessary positions and speeds of the two input motors, the two leading elements, are determined, 1 and 6. It is proposed to solve a simple algorithm in the program MathCad 2000, which uses for initiation the logical function If Log. The kinematic output parameters, i.e. the parameters of the foot and practically of the final effector, i.e. those of the point marked with T, will be determined for initiating the working algorithm using the logical functions, "If log (ical)", with the observation that here plays the role of parameters input; is positioned as already specified in reverse kinematics when the output is considered as input and input as output. The logical functions used, as well as the entire calculation program used, were written in Math Cad 2000.
Underutilization of workers: an analysis according to the lean management philosophy in basic education
Authors: Besser Freitag Alberto Eduardo , Barreto de Oliveira Alexandre
Published: December 2021

One of the eight wastes that Lean production, inspired by the Toyota Production System, proposes to study is the underutilization of workers, that is, the inadequate use of their intelligence. The sense is to provide listening and participation in improvement projects, of professionals who have experience in daily life and, in many cases, consistent academic qualifications.  The objective of this work is to study the importance of the participation of teachers and employees of a basic education school in the construction of new routines and work methods, in the context of the Lean management philosophy, justified by the scarcity of scientific literature on the subject. Brazil has about 184,000 basic education schools with one million four hundred thousand teachers working from kindergarten to the ninth grade of elementary school, and of these, 83.2% have a college degree, a percentage that grows every year. About the schools, 21.7% are private, 61.3% municipal, 16.6% state, and 0.4% are federal schools. As a research methodology, a systematic review of the literature was adopted, based on the PRISMA protocol, allowing the identification of 53 records, 14 of which were included in the literature review, due to their adherence to the researched subject. The main contribution of this paper is the identification of a research gap involving the underutilization of workers and adoption of the Lean management philosophy in the education sector, as well as a conceptual proposal of the positive impact on the educational organization results by not underutilizing workers, without wasting their intelligence.
Composition of binary quadratic forms over number fields
Authors: Zemková Kristýna
Published: December 2021

In this article, the standard correspondence between the ideal class group of a quadratic number field and the equivalence classes of binary quadratic forms of given discriminant is generalized to any base number field of narrow class number one. The article contains an explicit description of the correspondence. In the case of totally negative discriminants, equivalent conditions are given for a binary quadratic form to be totally positive definite.
Multiplicity of solutions for a class of fourth-order elliptic equations of p(x)-Kirchhoff type
Authors: Chung Nguyen Thanh , Naghizadeh Zohreh
Published: December 2021

This paper deals with a class of fourth order elliptic equations of Kirchhoff type with variable exponent

Δ

p
(
x
)

2

u
−
M

(

∫
Ω

1

p
(
x
)

|

∇
u

|

p
(
x
)

d
x

)

Δ

p
(
x
)

u
+

|

u

|

p
(
x
)
−
2

u
=
λ
f
(
x
,
u
)
+
μ
g
(
x
,
u
)

 in 
Ω
,

u
=
Δ
u
=
0

 on 
∂
Ω
,

$$\begin{array}{}
\left\{\begin{array}{}
\Delta^2_{p(x)}u-M\bigg(\displaystyle\int\limits_\Omega\frac{1}{p(x)}|\nabla u|^{p(x)}\,\text{d} x \bigg)\Delta_{p(x)} u + |u|^{p(x)-2}u = \lambda f(x,u)+\mu g(x,u) \quad \text{ in }\Omega,\\
u=\Delta u = 0 \quad \text{ on } \partial\Omega,
\end{array}\right.
\end{array}$$

where

p

−

:=

inf

x
∈

Ω
¯

p
(
x
)
>
max

1
,

N
2

,
λ
>
0

$\begin{array}{}
\displaystyle
p^{-}:=\inf_{x \in \overline{\Omega}} p(x) \gt \max\left\{1, \frac{N}{2}\right\}, \lambda \gt 0
\end{array}$

and μ ≥ 0 are real numbers, Ω ⊂ ℝ
N
(N ≥ 1) is a smooth bounded domain,

Δ

p
(
x
)

2

u
=
Δ
(

|

Δ
u

|

p
(
x
)
−
2

Δ
u
)

$\begin{array}{}
\displaystyle
\Delta_{p(x)}^2u=\Delta (|\Delta u|^{p(x)-2} \Delta u)
\end{array}$

is the operator of fourth order called the p(x)-biharmonic operator, Δ
p(x)
u = div(|∇u|
p(x)–2∇u) is the p(x)-Laplacian, p : Ω → ℝ is a log-Hölder continuous function, M : [0, +∞) → ℝ is a continuous function and f, g : Ω × ℝ → ℝ are two L
1-Carathéodory functions satisfying some certain conditions. Using two kinds of three critical point theorems, we establish the existence of at least three weak solutions for the problem in an appropriate space of functions.
Epigenetic function in neurodevelopment and cognitive impairment
Authors: Jakovcevski Mira , Zimmer-Bensch Geraldine
Published: December 2021

Brain development comprises a fine-tuned ensemble of molecular processes that need to be orchestrated in a very coordinated way throughout time and space. A wide array of epigenetic mechanisms, ranging from DNA methylation and histone modifications to noncoding RNAs, have been identified for their major role in guiding developmental processes such as progenitor proliferation, neuronal migration, and differentiation through precise regulation of gene expression programs. The importance of epigenetic processes during development is reflected by the high prevalence of neurodevelopmental diseases which are caused by a lack or mutation of genes encoding for transcription factors and other epigenetic regulators. Most of these factors process central functions for proper brain development, and respective mutations lead to severe cognitive defects. A better understanding of epigenetic programs during development might open new routes toward better treatment options for related diseases.
A Theory of ‘Too Big To Jail’
Authors: Bos Iwan
Published: December 2021

Motivated by some recent examples, this paper employs a model of public law enforcement to explain why it may not be in society’s interest to send criminals to prison. We establish two main findings. First, independent of the lawbreaker’s societal position, imprisonment is suboptimal when the harm from the illegal activity is sufficiently small. Second, for a given level of harm, imprisonment is suboptimal when the lawbreaker is sufficiently important. This latter result thus provides a rationale for why some parties are taken to be ‘too big to jail’.
Self-compassion in Acceptance and Commitment Therapy for chronic pain: a pilot study
Authors: Carvalho Sérgio A. , Gillanders David , Forte Teresa , Trindade Inês A. , Pinto-Gouveia José , Lapa Teresa , Valentim Ana , Santos Elsa , Paciência Juliana , Guiomar Raquel , Castilho Paula
Published: December 2021

Objectives

Evidence shows that Acceptance and Commitment Therapy (ACT) is an empirically supported psychological approach for chronic pain (CP) management. Although self-compassion is not explicitly a target of ACT, it seems to be one mechanism of change in ACT for CP. However, research is lacking on the benefits of including explicit self-compassionate exercises in ACT for CP. The current study pilot tested a Compassionate ACT 8-session group program (COMP.ACT; n=9), as well as an ACT-only 8-session group program (ACT; n=7), in a sample of women with CP.

Methods

The current study follows a quasi-experimental design, and conducts Reliable and Significant Change analyses comparing pre- to post-intervention scores of self-report measures.

Results

No differences were found between conditions at baseline, nor between completers and drop-outs. Although preliminary, results showed COMP.ACT led to greater clinical improvements in depression and anxiety, while ACT led to greater improvements in stress and uncompassionate self-responding. Reliable and Significant Change analysis showed that some participants improved significantly (in psychopathological symptoms, valued living and uncompassionate self-responding) in both conditions, while the majority did not change significantly.

Conclusions

More research is needed to conclude whether explicit self-compassion exercises are useful in ACT for CP. Limitations and implications are further discussed.
Performance evaluation of internal quality control rules, EWMA, CUSUM, and the novel machine learning model
Authors: Çubukçu Hikmet Can
Published: December 2021

Objectives

The present study set out to build a machine learning model to incorporate conventional quality control (QC) rules, exponentially weighted moving average (EWMA), and cumulative sum (CUSUM) with random forest (RF) algorithm to achieve better performance and to evaluate the performances the models using computer simulation to aid laboratory professionals in QC procedure planning.

Methods

Conventional QC rules, EWMA, CUSUM, and RF models were implemented on the simulation data using an in-house algorithm. The models’ performances were evaluated on 170,000 simulated QC results using outcome metrics, including the probability of error detection (Ped), probability of false rejection (Pfr), average run length (ARL), and power graph.

Results

The highest Pfr (0.0404) belonged to the 1–2s rule. The 1–3s rule could not detect errors with a 0.9 Ped up to 4 SD of systematic error. The random forest model had the highest Ped for systematic errors lower than 1 SD. However, ARLs of the model require the combined utility of the RF model with conventional QC rules having lower ARLs or more than one QC measurement is required.

Conclusions

The RF model presented in this study showed acceptable Ped for most degrees of systematic error. The outcome metrics established in this study will help laboratory professionals planning internal QC.
Turbulent boundary layer heat transfer of CuO–water nanofluids on a continuously moving plate subject to convective boundary
Authors: Zhang Jiaojiao , Liu Shengna , Zheng Liancun
Published: December 2021

The turbulent boundary layer (TBL) heat transfer of CuO–water nanofluids on a continuously moving plate subject to convective boundary are investigated. Five different shapes of nanoparticles are taken into account. Prandtl mixing length theory is adopted to divide the TBL into two parts, laminar sub-layer and turbulent region. The numerical solutions are obtained by bvp4c and accuracy is verified with previous results. It is found that the transfer of momentum and heat in the TBL is more obvious in laminar sub-layer than in turbulent region. The rise of velocity ratio parameter increases the velocity and temperature while decreases the local friction coefficient. The heat transfer increases significantly with the increase of velocity ratio parameter, Biot number, and nanoparticles volume fraction. For nanoparticles of different shapes, the heat transfer characteristics are Nu
x
(sphere) < Nu
x
(hexahedron) < Nu
x
(tetrahedron) < Nu
x
(column) < Nu
x
(lamina).
A MIGRAÇÃO CONTEMPORÂNEA EM MATO GROSSO DO SUL
Authors: Nakazato Michele , Dorsa Arlinda Cantero , Britts Thiago Henrique Conde
Published: December 2021

As reflexões produzidas sobre os problemas sociais contemporâneos, com relação aos estudos migratórios nos últimos anos é uma realidade que vem inspirando muitos pesquisadores ao aprofundamento dessa discussão. Neste prisma, este artigo apresenta um estudo sobre a migração contemporânea em Mato Grosso do Sul, partindo-se da questão norteadora sobre qual é a realidade da migração no estado do MS. Objetiva, portanto, a partir de um estudo exploratório, bibliográfico e documental, aprofundar a realidade vivida no MS sobre esta temática. Com relação aos estudos bibliográficos, apresenta uma tipologia conceitual sobre migração, refugiados, suas implicações no território e territorialidade e possibilidades do receber e acolher. Infere-se dessa pesquisa que há uma necessidade de se promover a possibilidade de redução do preconceito e discriminação em relação aos imigrantes, desenvolvendo um equilíbrio humanitário no novo território que o acolhe para a formação de uma nova territorialidade e que contribua para o desenvolvimento local.
ESTUDOS DOS PADRÕES DE CONSUMO DE ÁLCOOL EM MULTI-TERRITÓRIOS POR ADOLESCENTES
Authors: Da Silva Maria Romilda , Favieri Giusepe , De Castilho Maria Augusta
Published: December 2021

Este estudo tem como ponto de partida a problemática sobre o consumo de álcool entre adolescentes. Para explicitar esta problematização tem-se o tema: Estudos dos padrões de consumo de álcool em multiterritórios por adolescentes. Trata-se de uma análise bibliográfica com técnica qualitativa e quantitativa das pesquisas científicas executadas por CEBRID disponíveis na web. A amostragem é um recorte do público pesquisado disposto nas pesquisas estudadas, sendo os adolescentes. O método utilizado foi dedutivo porque permite iniciar os estudos a partir de uma ideia geral para chegar à uma compreensão específica. Para tanto, foram traçados objetivos norteadores, sendo o geral: analisar os padrões de consumo de álcool em multiterritórios de adolescentes no contexto da multi-territorialidade brasileira e específicos: destacar os padrões de consumo de álcool por adolescentes e discriminar as dimensões dos padrões de consumo de álcool por adolescentes entre território brasileiro. Os critérios para filtragem e análise dos dados foram: leituras minuciosas das sessões que continha o público adolescente; abstraindo os dados sobre os padrões de consumo de álcool por adolescentes, como: frequências, sinais, sintomas, tolerância, problemas, situações de risco, opiniões nos multi-territórios.