bluuebunny/crossref_metadata_2025 huggingface dataset:
Virtual-reality-based social cognition and interaction training for patients with schizophrenia: A preliminary efficacy study
Authors: Shen Zhi-Hua , Liu Meng-Hui , Wu Yue , Lin Qian-Qian , Wang Yong-Guang
Published: November 2022

Background

Social cognition and interaction training (SCIT) is a psychosocial intervention program for patients with psychosis, designed to improve their social functioning by improving social cognition. Although the feasibility and efficacy of SCIT have been verified, patients with schizophrenia tend to suffer from motivational deficits and low treatment adherence. It has been suggested that using virtual reality (VR) technology might be effective in addressing these issues. In this study, we aimed to develop a VR-based SCIT and compare its efficacy with that of traditional SCIT.

Materials and methods

We developed a novel VR-based social cognition and interaction training (VR-SCIT) that combines traditional SCIT (TR-SCIT) intervention with VR technology. Participants were randomly assigned in a 1:1:1 ratio to the VR-SCIT (n = 28), TR-SCIT (n = 30), or waiting-list groups (n = 29). All treatments were combined with treatment-as-usual. Assessments of social cognition (i.e., Chinese version of Face-Affective Identification Task, Chinese version of Social Cognition Screening Questionnaire) and social functioning (i.e., Chinese version of Personal and Social Performance Scale) were administered from baseline to post-intervention.

Results

Patients receiving VR-SCIT and TR-SCIT showed a significantly greater improvement on the assessments of emotion perception (Cohen’s d was 1.66, 0.55, and 0.10 for VR-SCIT, TR-SCIT, and Waiting-list, respectively), hostile attributional bias (Cohen’s d was 0.48, 0.44, and 0.05 for VR-SCIT, TR-SCIT, and Waiting-list, respectively), metacognition (Cohen’s d was 1.66, 0.76, and 0.06 for VR-SCIT, TR-SCIT, and waiting-list, respectively), and social functioning (Cohen’s d was 1.09, 0.90, and 0.20 for VR-SCIT, TR-SCIT, and waiting-list, respectively) from baseline to post-intervention, compared to those in waiting-list group. Additionally, VR-SCIT showed an advantage over TR-SCIT in improving emotion perception and metacognition with higher treatment compliance.

Conclusion

These preliminary findings indicate that VR-SCIT is a feasible and promising method for improving social cognition and social functioning in patients with schizophrenia.
Diagnosis of children with attention-deficit/hyperactivity disorder (ADHD) comorbid autistic traits (ATs) by applying quantitative magnetic resonance imaging techniques
Authors: Tang Shilong , Liu Xianfan , Nie Lisha , Chen Zhuo , Ran Qiying , He Ling
Published: November 2022

Objective

To explore the feasibility of applying quantitative magnetic resonance imaging techniques for the diagnosis of children with attention-deficit/hyperactivity disorder (ADHD) comorbid autistic traits (ATs).

Methods

A prospective study was performed by selecting 56 children aged 4–5 years with ADHD-ATs as the study group and 53 sex- and age-matched children with ADHD without ATs as the control group. All children underwent magnetic resonance scans with enhanced T2*- weighted magnetic resonance angiography (ESWAN), 3D-PCASL, and 3D-T1 sequences. Iron content and cerebral blood flow parameters were obtained via subsequent software processing, and the parameter values in particular brain regions in both groups were compared and analyzed to determine the characteristics of these parameters in children with ADHD-ATs.

Results

Iron content and cerebral blood flow in the frontal lobe, temporal lobe, hippocampus, and caudate nucleus of children with ADHD-ATs were lower than those of children with ADHD without ATs (p < 0.05). Iron content and CBF values in the frontal lobe, temporal lobe and caudate nucleus could distinguish children with ADHD-ATs from those without ATs (AUC > 0.5, p < 0.05).

Conclusions

Quantitative magnetic resonance techniques could distinguish children with ADHD-ATs.

Trial registration

This study protocol was registered at the Chinese clinical trial registry (ChiCTR2100046616).
Factor structure and psychometric properties of the affective lability scale-short form in Chinese adolescents
Authors: Xu Shuyin , Chen Yafei , Li Yunjing , Yang Siqi , Lu Yimei , Li Liang , Huang Mei , Ma Mohan , Ou Wenwen , Lv Guanyi , Zhao Xiaotian , Qin Yaqi , Ju Yumeng , Zhang Yan , Li Lingjiang
Published: November 2022

Objective

Previous studies on the reliability and validity of the Affective Lability Scale short-form (ALS-SF) have only been evaluated in adults, which may not be able to generalize to the adolescent population. We aimed to examine the factor structure, the reliability and validity of ALS-SF among Chinese adolescents and construct an adolescent form of ALS (ALS-AF).

Methods

A total of 1,439 middle school students were investigated with a broad survey including ALS-SF, Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder 7-item (GAD-7), Connor-Davidson Resilience Scale 10-item (CD-RISC-10) and non-suicidal self-injury (NSSI) behavior self-report. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were conducted to investigate the structural validity of ALS-SF and construct ALS-AF. Cronbach's α was used to assess the internal consistency and reliability of the scale. Factor loading, Average Variance Extracted (AVE) and Composite Reliability (CR) were applied to measure the convergent validity and divergent validity. Besides, Correlation and regression analyses were used to explore the relationship between affective lability and depression, anxiety, NSSI and resilience.

Results

Factor analysis failed to support the original three-factor model of 18-item ALS-SF and confirmed the three-factor model of 15-item ALS-AF. The ALS-AF showed good internal consistency as well as strong convergent and discriminative validity. Besides, ALS-AF was positively correlated with PHQ-9, GAD-7 and self-harm, and was negatively associated with resilience.

Conclusion

Our study shows that the ALS-AF has good reliability and validity for testing affective lability in Chinese adolescents.
Microglia: Synaptic modulator in autism spectrum disorder
Authors: Hu Cong , Li Heli , Li Jinhui , Luo Xiaoping , Hao Yan
Published: November 2022

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by variable impairment of social communication and repetitive behaviors, highly restricted interests, and/or sensory behaviors beginning early in life. Many individuals with ASD have dysfunction of microglia, which may be closely related to neuroinflammation, making microglia play an important role in the pathogenesis of ASD. Mounting evidence indicates that microglia, the resident immune cells of the brain, are required for proper brain function, especially in the maintenance of neuronal circuitry and control of behavior. Dysfunction of microglia will ultimately affect the neural function in a variety of ways, including the formation of synapses and alteration of excitatory–inhibitory balance. In this review, we provide an overview of how microglia actively interact with neurons in physiological conditions and modulate the fate and functions of synapses. We put a spotlight on the multi-dimensional neurodevelopmental roles of microglia, especially in the essential influence of synapses, and discuss how microglia are currently thought to influence ASD progression.
Antibiotic resistant bacteria: A bibliometric review of literature
Authors: Sun Guojun , Zhang Qian , Dong Zuojun , Dong Dashun , Fang Hui , Wang Chaojun , Dong Yichen , Wu Jiezhou , Tan Xuanzhe , Zhu Peiyao , Wan Yuehua
Published: November 2022

Antibiotic-resistant bacteria (ARB) are a serious threat to the health of people and the ecological environment. With this problem becoming more and more serious, more countries made research on the ARB, and the research number has been sharply increased particularly over the past decade. Therefore, it is quite necessary to globally retrace relevant researches on the ARB published from 2010 to 2020. This will help researchers to understand the current research situation, research trends and research hotspots in this field. This paper uses bibliometrics to examine publications in the field of ARB from 2010 to 2020 that were retrieved from the Web of Science (WOS). Our study performed a statistical analysis of the countries, institutions, journals, authors, research areas, author keywords, Essential Science Indicators (ESI) highly cited papers, and ESI hotspots papers to provide an overview of the ARB field as well as research trends, research hotspots, and future research directions in the field. The results showed that the number of related studies is increasing year by year; the USA is most published in the field of ARB; China is the most active in this field in the recent years; the Chinese Acad Sci published the most articles; Sci. Total Environ. published the greatest number of articles; CM Manaia has the most contributions; Environmental Sciences and Ecology is the most popular research area; and “antibiotic resistance,” “antibiotics,” and “antibiotic resistance genes” were the most frequently occurring author keywords. A citation analysis showed that aquatic environment-related antibiotic resistance is a key research area in this field, while antimicrobial nanomaterial-related research is a recent popular topic.
State policies that promote, and that inhibit, improved public health: An exploratory analysis of paid sick leave
Authors: Wolf Douglas A.
Published: November 2022

The United States has no national requirement that employers provide paid sick leave (PSL) to their employees, despite the many established public health benefits of PSL access. Many states, and some localities, have passed laws requiring PSL within their jurisdictions. Past studies have shown that these PSL mandates are effective in promoting increased PSL access. However, past studies have not considered two other commonly-used state policy initiatives—PSL preemption and right-to-work laws—that could hypothetically influence employers' decisions to provide PSL. During the past few decades, all possible combinations of these policy interventions can be found in one or more U.S. states. This study estimates the combined associations of these 3 policies with PSL access. The estimates support recent research on the positive effects of PSL mandates, but also suggest that PSL preemption and right-to-work laws may have offsetting effects. Failure to take account of these additional policies may lead to an over-estimate of the effectiveness of PSL mandates.
Substantial increase in perceived benefits over harms of COVID-19 outbreak but persistent socioeconomic disparities: Comparison of two cross-sectional surveys in Hong Kong from 2020 to 2021
Authors: Leung Hiu Tin , Gong Wei Jie , Sit Shirley Man Man , Lai Agnes Yuen Kwan , Ho Sai Yin , Wang Man Ping , Lam Tai Hing
Published: November 2022

Background

We have reported both perceived benefits and harms of the COVID-19 outbreak and their socioeconomic disparities amid the pandemic in Hong Kong. We further investigated whether such perceptions and disparities had changed after 10 months.

Methods

Under the Hong Kong Jockey Club SMART Family-Link Project, we conducted two cross-sectional surveys online on perceived personal and family benefits and harms of the COVID-19 outbreak in Hong Kong adults in May 2020 (after Wave 2 was under control; N = 4,891) and in February and March 2021 (after Wave 4 was under control; N = 6,013). We collected sociodemographic information, including sex, age, education, household income, and housing. Using multivariate models of analysis of covariance (MANCOVA), we compared perceived benefits and harms and socioeconomic disparities between the two surveys.

Results

Adjusting for sex and age, the prevalence of 17 out of 18 perceived personal and family benefits of COVID-19 outbreak increased (Ps < 0.001). Six of 11 perceived personal and family harms decreased (Ps < 0.001) and 4 increased (Ps < 0.001). The total number of perceived personal and family benefits increased substantially (Ps < 0.001), whereas that of perceived personal harms decreased (P = 0.01) and family harms remained stable (P > 0.05). Socioeconomic disparities, however, persisted—more perceived benefits in those with higher socioeconomic status (Ps < 0.001) and more perceived harms in those with lower (Ps ≤ 0.005).

Conclusion

We have first reported that perceived personal and family benefits of the COVID-19 outbreak increased substantially over 10 months amid the pandemic, while perceived personal and family harms were lower and stable, respectively. Socioeconomic disparities of the perceived benefits and harms persisted, which need to be monitored and addressed urgently.
Ensuring continuity of care during the COVID-19 pandemic in Guinea: Process evaluation of a health indigent fund
Authors: Barry Lansana , Kouyaté Mariama , Sow Abdoulaye , De Put Willem Van , De Maesschalck John , Camara Bienvenu Salim , Adrianaivo Norohaingo , Delamou Alexandre
Published: November 2022

Background

The emergence of the COVID-19 has disrupted the health and socioeconomic sectors, particularly in resource-poor settings such as Guinea. Like many sub-Saharan countries, Guinea is facing shortcomings related to its fragile health system and is further affected by the passage of the Ebola virus disease. The pandemic has worsened the socio-economic situation of the poorest people, leading to their exclusion from health care. To promote access to care for the most vulnerable populations, a system was set up to provide care for these people who are victims of health marginalization to promote their access to care. This study aimed to analyze access to health services by vulnerable populations during the COVID-19 pandemic in Guinea through the establishment of a health indigent fund (HIF).

Methods

This was a qualitative study to assess the project implementation process. A total of 73 in-depth individual interviews were conducted with beneficiaries, health workers, community health workers and members of the HIF management committee, and a few informal observations and conversions were also conducted in the project intervention areas. The data collected were transcribed and coded using the deductive and inductive approaches with the Nvivo software before applying the thematic analysis.

Results

A total of 1,987 indigents were identified, of which 1,005 were cared for and 64 referred to all 38 intervention health facilities within the framework of the HIF. All participants appreciated the project's social action to promote access to equitable and quality health care for this population excluded from health care services. In addition, the project has generated waves of compassion and solidarity toward these “destitute” people whose main barrier to accessing health care remains extreme poverty. A state of poverty that leads some to sell their assets (food or animal reserves) or to go into debt to ensure access to care for their children, considered the most at risk.

Conclusion

The HIF can be seen as an honest attempt to provide better access to health care for the most vulnerable groups. Some challenges need to be addressed including the current system of acquiring funds before the attempt can be considered scalable.
Knowledge, attitude and practice of diabetes among secondary school-going children in Bangladesh
Authors: Akter Farhana , Rashid S. M. Mahbubur , Alam Nazmul , Lipi Nasrin , Qayum Md. Omar , Nurunnahar Mehejabin , Mannan Adnan
Published: November 2022

Diabetes Mellitus (DM) is a global public health concern. DM has been increasing alarmingly among the young people and childhood-onset has now become an emerging issue worldwide. Unlike other chronic diseases, DM requires constant and active attention of the patients, sometimes of their family members for successful management of this disease. Knowledge, attitude, and practices make significant differences at the population level, which largely depend on socioeconomic status, area of residence, level of education, and other socio-demographic attributes. A descriptive cross-sectional study was carried out among secondary school students in grades 6 through 10 attending schools in 18 districts of Bangladesh. A total of 2009 students were enrolled for the study from the selected schools and madrasas from Bengali, English, and Arabic medium. The majority of responders (79.34%) reported that they had heard of diabetes, however, only 45% knew that diabetes can cause blood glucose levels to rise. Among different therapeutic options, only 15% of students had heard the name of metformin, while 56.2% were familiar with insulin. English medium students were significantly more likely to have good knowledge than the Bangla medium students (19.31%, OR: 1. 44; 95% CI: 1.07, 1.95). Respondents of semi-urban (19.66%, OR: 1.7; 95% CI: 1.21, 2.36) and urban (18.47%, OR: 1.48; 95% CI: 1.17, 1.86) areas were more likely to have good knowledge than rural areas. Of the respondents, 20.61% did not know of any diabetic treatment options. Only a small percentage of students (11%) attended any diabetes education classes and 10.7% of students followed any recommended diabetes prevention methods. Knowledge, attitude, and practice related to diabetes were found to have been influenced by socioeconomic factors, societal practices, and behavioral patterns. This is the first nationwide research study in Bangladesh among secondary school students to study knowledge, attitudes, and practices related to diabetes. With a focus on Bangladesh's youthful population, this study sought to provide an informational framework that can be supportive for effective intervention to increase knowledge of diabetes and its implications.
Providing HIV testing in men who have sex with men through a gay social networking app in China: A qualitative interview study with multisectoral service providers
Authors: Zhao Tianming , Cao Zhaobing , Jiang Zhen , Bulloch Gabriella , Qiu Yanchao , Liu Lihua , Wang Lijing , Li Yingxia , Jia Ce , Guo Li , Wu Zunyou
Published: November 2022

Objective

We explored the feasibility of app-based HIV testing services (AHTS) among men who have sex with men (MSM) according to the perspectives of testing service providers.

Methods

Twenty-one current or previous AHTS providers participated in a semi-structured interview which explored the facilitators and barriers to AHTS. Ten participants originating from the Center for Disease Control and Prevention (CDC) and 11 from the non-governmental organization (NGO) in Shijiazhuang, China took part in this study. Interviews was transcribed verbatim, and the socioecological model (SEM) was applied to thematic analysis.

Results

Twenty-one participants from AHTS services commented on the integration of online appointment schedules into HIV testing services. AHTS was deemed a convenient and efficient method for MSM and service providers to choose their preferred location and times. Moreover, it allowed for important HIV-related information to be accessed online and targeted toward at-risk individuals. Participants thought MSM may feel unsure about personal information security being stored within a privatized app and was considered a barrier to AHTS's usability. As such, they believed establishing a government-led national online platform for AHTS would allow for greater trust from MSM, rather than a social media app.

Conclusion

By linking booking services to an online platform, AHTS was deemed a convenient and efficient method for HIV testing services, especially for young MSM who are familiar with smartphone applications. To improve the use of these services, AHTS apps should focus on ensuring the confidentiality of personal information and internet security to build trust between MSM and service providers.
Using serious mobile games to improve health literacy in rural Sub-Saharan Africa: A literature review
Authors: Ouedraogo Ismaila , Some Borlli Michel Jonas , Oyibo Kiemute , Benedikter Roland , Diallo Gayo
Published: November 2022

The African gaming industry is beginning to flourish as a result of a rise in the availability of inexpensive phones and the number of mobile phone subscribers. It has enabled the development and implementation of mobile serious games to promote healthy behavior change in rural communities. This paper examines the use of mobile serious games in healthcare education, with a particular focus on those designed to increase health literacy in rural Africa. Identifying and addressing the design challenges and issues faced by people living in rural African communities through the use of persuasive mobile games can promote behavior change among these underserved communities. We used PubMed, Scopus, Google Scholar and manual search to identify relevant studies published from 2011 to July 2021. The literature review highlights how the identified challenges affect the implementation of persuasive strategies, suggests design solutions for overcoming them, and discusses how persuasive games can be tailored to suit the target rural African populations. Some of the identified challenges are technical in nature (e.g., access to electricity and internet connectivity), while others are not (e.g., language diversity and low literacy). As the number of serious games for healthcare education and awareness continues to increase, it is essential for the successful implementation of inclusive mobile health technologies in rural Africa to identify and address the specific challenges faced by underserved populations such as rural African communities.
Compliance with a personalised home exercise programme in chronic low back pain patients after a multidisciplinary programme: A pilot randomised controlled trial
Authors: Lenoir dit Caron R. , Rouzée M. , Coquart J. , Gilliaux M.
Published: November 2022

Background

Chronic low back pain (CLBP) is a very common problem throughout the world. One treatment possibility is the multidisciplinary programme (MP) in a rehabilitation centre, which provides intensive rehabilitation through physical exercise to quickly improve the patient conditions. Patients nevertheless do not always continue the exercises when they return home. This study thus evaluated compliance with a personalised home-based programme for CLBP patients post-MP.

Methods

A randomised controlled single-blind trial was conducted. Thirty patients were randomised into two groups and participated in an MP for 4 weeks. They were then given an exercise booklet for home rehabilitation. In addition, each patient in the experimental group constructed a personalised exercise programme with a physiotherapist. The control group was only encouraged to continue the exercises at home. To assess therapeutic compliance, both groups were asked to document each completed exercise in a logbook. In addition, pain intensity, flexibility, muscle endurance, activity limitations, participation restrictions, and beliefs about physical activity were assessed at the beginning and end of the MP and again after 12 weeks at home.

Results

Compliance was good for all activities in both groups, but there were no significant differences between groups. All participants improved on the criteria by the end of MP, and both groups maintained the improvements in most of the criteria at 3-month follow-up.

Conclusion

This study showed the effectiveness of an MP for CLBP in the short and medium term. However, future research should focus on longer-term compliance.
Digital body, identity and privacy in social virtual reality: A systematic review
Authors: Lin Jinghuai , Latoschik Marc Erich
Published: November 2022

Social Virtual Reality (social VR or SVR) provides digital spaces for diverse human activities, social interactions, and embodied face-to-face encounters. While our digital bodies in SVR can in general be of almost any conceivable appearance, individualized or even personalized avatars bearing users’ likeness recently became an interesting research topic. Such digital bodies show a great potential to enhance the authenticity of social VR citizens and increase the trustworthiness of interpersonal interaction. However, using such digital bodies might expose users to privacy and identity issues such as identity theft: For instance, how do we know whether the avatars we encounter in the virtual world are who they claim to be? Safeguarding users’ identities and privacy, and preventing harm from identity infringement, are crucial to the future of social VR. This article provides a systematic review on the protection of users’ identity and privacy in social VR, with a specific focus on digital bodies. Based on 814 sources, we identified and analyzed 49 papers that either: 1) discuss or raise concerns about the addressed issues, 2) provide technologies and potential solutions for protecting digital bodies, or 3) examine the relationship between the digital bodies and users of social VR citizens. We notice a severe lack of research and attention on the addressed topic and identify several research gaps that need to be filled. While some legal and ethical concerns about the potential identity issues of the digital bodies have been raised, and despite some progress in specific areas such as user authentication has been made, little research has proposed practical solutions. Finally, we suggest potential future research directions for digital body protection and include relevant research that might provide insights. We hope this work could provide a good overview of the existing discussion, potential solutions, and future directions for researchers with similar concerns. We also wish to draw attention to identity and privacy issues in social VR and call for interdisciplinary collaboration.
Ontological and epistemological commitments in interdisciplinary water research: Uncertainty as an entry point for reflexion
Authors: Krueger Tobias , Alba Rossella
Published: November 2022

Against the background of a renewed interest in interdisciplinary water research, we begin this paper by diagnosing a need for deeper engagement at the epistemological and ontological level. We then analyse the ontological and epistemological commitments of three modeling examples: an academic human-flood model, a nutrient transfer decision support model and a policy facing water security model. These examples demonstrate how research practices are not neutral but intervene in the world by distributing agency unequally, providing naturalized and de-politicized explanations of the past and pre-configuring certain futures while foreclosing others. Lastly, we position hydrology's uncertainty tradition and its problematisation of choices in the research process as an entry point for reflexion on the contingencies of and ethical responsibility for research practices. This uncertainty tradition provides more common ground for collaboration between hydrologists and critical water researchers than previously acknowledged, while such collaboration would still thrive on confrontation. We conclude with a call for greater humility in water research, especially when using models, and practical suggestions for how researchers could uncover ontological and epistemological commitments and live up to the ethical responsibility they entail.
Lessons learned from water-scarce cities: Proposed policies toward an integrated urban water management in Egypt
Authors: ElZein Zeina , Abdou Amal , Säumel Ina
Published: November 2022

Water scarcity is one of the main challenges facing countries in arid or semi-arid zones. As an example, Egypt needs to deal with both insufficient quantity and quality of water for residents. Here, we propose actions and policies to promote an integrated water management approach to respond to water challenges in Egypt. Based on a literature review, we have selected a set of criteria concerning the environmental, economic, social, governmental, and physical dimensions of urban water management. We studied approaches from Peru, Namibia, and South Australia as these countries have similar climatic conditions and water issues and have made substantial advances toward sustainable water management. Key criteria are state or municipal ownership of water and related infrastructure, agreement on master plans for sustainable water management, improvement of water sanitation and overall infrastructure, and reduction of water demand. Participatory, and educational campaigns put water issues at the center of public debates. We evaluated which elements of water management approaches can be adapted and used in Egypt, which faces limited freshwater resources, and which faces a highly increasing population. Proposed actions included directing water fees to ecosystem projects, treatment of wastewater to be potable, participatory approaches that engage the community in water management, educational campaigns that lead to change of public perception and knowledge dissemination. We interviewed key stakeholders in the water sector in Egypt to validate our proposed approaches. The stakeholders supported knowledge dissemination, suggested using water fees in implementing environmental projects and criticized converting wastewater into drinking water. Finally, we drafted specific recommendations at the organizational and urban levels of water management. We recommended establishing a General Organization for Water Management to oversee water-related organizations and ministries. We also recommended prioritizing the economic conditions to support alleviation of water subsidy, increasing public awareness, and creating a public database for water knowledge. In addition, we recommended decentralized water management and water sensitive urban design. The value of these approaches is their applicability, with minor adaptations, to countries with similar or close climatic and socio-economic conditions to Egypt, such as the MENA region.
STELLA—Potential European contributions to a NASA-led interstellar probe
Authors: Wimmer-Schweingruber Robert F. , André Nicolas , Barabash Stanislav , Brandt Pontus C. , Horbury Timothy S. , Iess Luciano , Lavraud Benoit , McNutt Ralph L. , Provornikova Elena A. , Quémerais Eric , Wicks Robert , Wieser Martin , Wurz Peter
Published: November 2022

The discovery of a myriad of exoplanets in the past decades has revolutionized the understanding of our place in the Universe. How different are exoplants and do some of them harbor life, just like Earth? To do so, their parent stars must drive a stellar wind and carve what we call astrospheres into the surrounding interstellar medium. Astrospheres are ubiquitous in our immediate neighborhood and show similar structure to our heliosphere. Voyager 1 and 2, Ulysses, Cassini, and IBEX have shown that the interaction between interstellar medium and solar wind is much more complex and involved than previously believed. This stellar-interstellar interaction is key to understand astrospheres and the shielding they provide to the planetary systems they harbor. This article summarizes a whitepaper that was submitted to NASA’s 2023/2024 decadal survey which is being conducted by the US National Academies. It is based in parts on a proposal submitted to the European Space Agency (ESA) in response to its 2021 call for medium-class mission proposals. The whitepaper and this article propose to study the interaction described above in situ at the heliospheric boundaries and to explore the very local interstellar medium beyond. Furthermore, they highlight possible European contributions to a NASA-led Interstellar Probe (ISP).
Prospects and challenges of numerical modeling of the Sun at millimeter wavelengths
Authors: Wedemeyer Sven , Fleishman Gregory , de la Cruz Rodríguez Jaime , Gunár Stanislav , da Silva Santos João M. , Antolin Patrick , Guevara Gómez Juan Camilo , Szydlarski Mikolaj , Eklund Henrik
Published: November 2022

The Atacama Large Millimeter/submillimeter Array (ALMA) offers new diagnostic possibilities that complement other commonly used diagnostics for the study of the Sun. In particular, ALMA’s ability to serve as an essentially linear thermometer of the chromospheric gas at unprecedented spatial resolution at millimeter wavelengths and future polarization measurements has great diagnostic potential. Solar ALMA observations are therefore expected to contribute significantly to answering long-standing questions about the structure, dynamics, and energy balance of the outer layers of the solar atmosphere. In this regard, current and future ALMA data are also important for constraining and further developing numerical models of the solar atmosphere, which in turn are often vital for the interpretation of observations. The latter is particularly important given the Sun’s highly intermittent and dynamic nature that involves a plethora of processes occurring over extended ranges in spatial and temporal scales. Realistic forward modeling of the Sun therefore requires time-dependent three-dimensional radiation magnetohydrodynamics that account for non-equilibrium effects and, typically as a separate step, detailed radiative transfer calculations, resulting in synthetic observables that can be compared to observations. Such artificial observations sometimes also account for instrumental and seeing effects, which, in addition to aiding the interpretation of observations, provide instructive tools for designing and optimizing ALMA’s solar observing modes. In the other direction, ALMA data in combination with other simultaneous observations enable the reconstruction of the solar atmospheric structure via data inversion techniques. This article highlights central aspects of the impact of ALMA for numerical modeling of the Sun and their potential and challenges, together with selected examples.
Relationship between geomagnetic storms and occurrence of ionospheric irregularities in the west sector of Africa during the peak of the 24th solar cycle
Authors: Ondede George Ochieng , Rabiu A. B. , Okoh Daniel , Baki Paul , Olwendo Joseph , Shiokawa Kazuo , Otsuka Yuichi
Published: November 2022

The study of ionospheric irregularities is important since many technological systems might be influenced by the ionosphere. In this work, we use data from the Global Navigation Satellite Systems (GNSS) receiver installed in Abuja, Nigeria, GPS Scintillation Network Decision Aid (SCINDA) TEC data from the Air Force Research Laboratory (AFRL) data archive, and the geomagnetic data from the World Data Center (WDC) in Kyoto, Japan, to investigate the relationship between geomagnetic storm and ionospheric irregularity occurrences using the rate of change of total electron content (TEC) index (ROTI), with a validation using the S4 indices, during the peak of the 24th solar cycle. The occurrences of irregularities were investigated on day-to-day and seasonal bases. The nighttime ionospheric irregularities, which are attributed to ionospheric plasma irregularities in the equatorial ionospheric F-region, were found to be prevalent. To investigate the relationship between the strength of ionospheric irregularities (ROTI) and the geomagnetic storm (Dst), the periodogram power spectral density (PSD) and regression analysis were used. The results showed that there was no correlation, cc = 0.073, between the Dst and ROTI, implying that the strengths of ionospheric irregularities occurring during geomagnetic storms are not strictly decided by the magnitudes of the storms; this was also confirmed using the S4 index. The impact of geomagnetic storms caused enhanced development or inhibition of ionospheric irregularities. We observed that the bulk of the storms occurring during the period of this study is not associated with ionospheric irregularities. Finally, the investigation showed that the correlation between the ROTI and Dst observed during the coronal mass ejection (CME)-driven geomagnetic storms was higher than that during the corotating interaction region (CIR)-driven geomagnetic storms, during the peak of the 24th solar cycle. The results of this work confirm the findings by other researchers.
Improvements in spatiotemporal outcomes, but not in recruitment of automatic postural responses, are correlated with improved step quality following perturbation-based balance training in chronic stroke
Authors: Staring Wouter H. A. , van Duijnhoven Hanneke J. R. , Roelofs Jolanda M. B. , Zandvliet Sarah , den Boer Jasper , Lem Frits C. , Geurts Alexander C. H. , Weerdesteyn Vivian
Published: November 2022

Introduction

People with stroke often exhibit balance impairments, even in the chronic phase. Perturbation-based balance training (PBT) is a therapy that has yielded promising results in healthy elderly and several patient populations. Here, we present a threefold approach showing changes in people with chronic stroke after PBT on the level of recruitment of automatic postural responses (APR), step parameters and step quality. In addition, we provide insight into possible correlations across these outcomes and their changes after PBT.

Methods

We performed a complementary analysis of a recent PBT study. Participants received a 5-week PBT on the Radboud Fall simulator. During pre- and post-intervention assessments participants were exposed to platform translations in forward and backward directions. We performed electromyography of lower leg muscles to identify changes in APR recruitment. In addition, 3D kinematic data of stepping behavior was collected. We determined pre-post changes in muscle onset, magnitude and modulation of recruitment, step characteristics, and step quality. Subsequently, we determined whether improvements in step or muscle characteristics were correlated with improved step quality.

Results

We observed a faster gastrocnemius muscle onset in the stance and stepping leg during backward stepping. During forward stepping we found a trend toward a faster tibialis anterior muscle onset in the stepping leg. We observed no changes in modulation or magnitude of muscle recruitment. Leg angles improved by 2.3° in forward stepping and 2.5° in backward stepping. The improvement in leg angle during forward stepping was accompanied by a −4.1°change in trunk angle, indicating a more upright position. Step length, duration and velocity improved in both directions. Changes in spatiotemporal characteristics were strongly correlated with improvements in leg angle, but no significant correlations were observed of muscle onset or recruitment with leg or trunk angle.

Conclusion

PBT leads to a multi-factorial improvement in onset of APR, spatiotemporal characteristics of stepping, and reactive step quality in people with chronic stroke. However, current changes in APR onset were not correlated with improvement in step quality. Therefore, we suggest that, in addition to spatiotemporal outcomes, other characteristics of muscle recruitment or behavioral substitution may induce step quality improvement after PBT.
Transcriptome-based selection and validation of optimal reference genes in perirenal adipose developing of goat (Capra hircus)
Authors: Zhao Le , Yang Haili , Li Xingchun , Zhou Yumei , Liu Taolu , Zhao Yongju
Published: November 2022

Brown adipose tissue (BAT) is mainly present in young mammals and is important for maintaining body temperature in neonatal mammals because of its ability to produce non-shivering thermogenesis. There is usually a large amount of BAT around the kidneys of newborn kids, but the BAT gradually “whiting” after birth. Screening and validating appropriate reference genes is a prerequisite for further studying the mechanism of goat brown adipose tissue “whiting” during the early stages. In this study, the expression stability of 17 candidate reference genes: 12 COPS8, SAP18, IGF2R, PARL, SNRNP200, ACTG1, CLTA, GANAB, GABARAP, PCBP2, CTSB, and CD151) selected based on previous transcriptome data as new candidate reference genes, 3 (PFDN5, CTNNB1, and EIF3M) recommended in previous studies, and 2 traditional reference genes (ACTB and GAPDH) was evaluated. Real-time quantitative PCR (RT-qPCR) technology was used to detect the expression level of candidate reference genes during goat BAT “whiting”. Four algorithms: Normfinder, geNorm, ΔCt method, and BestKeeper, and two comprehensive algorithms: ComprFinder and RefFinder, were used to analyze the stability of each candidate reference genes. GABARAP, CLTA, GAPDH, and ACTB were identified as the most stable reference genes, while CTNNB1, CTSB, and EIF3M were the least stable. Moreover, two randomly selected target genes IDH2 and RBP4, were effectively normalized using the selected most stable reference genes. These findings collectively suggest that GABARAP, CLTA, GAPDH, and ACTB are relatively stable reference genes that can potentially be used for the development of perirenal fat in goats.
A Worldwide Survey of Activities and Practices in Clinical Islet of Langerhans Transplantation
Authors: Berney Thierry , Andres Axel , Bellin Melena D. , de Koning Eelco J. P. , Johnson Paul R. V. , Kay Thomas W. H. , Lundgren Torbjörn , Rickels Michael R. , Scholz Hanne , Stock Peter G. , White Steve ,   the International Islet Transplant Centers
Published: November 2022

A global online survey was administered to 69 islet transplantation programs, covering 84 centers and 5 networks. The survey addressed questions on program organization and activity in the 2000–2020 period, including impact on activity of national health care coverage policies. We obtained full data from 55 institutions or networks worldwide and basic activity data from 6 centers. Additional data were obtained from alternative sources. A total of 94 institutions and 5 networks was identified as having performed islet allotransplantation. 4,365 islet allotransplants (2,608 in Europe, 1,475 in North America, 135 in Asia, 119 in Oceania, 28 in South America) were reported in 2,170 patients in the survey period. From 15 centers active at the start of the study period, the number of simultaneously active islet centers peaked at 54, to progressively decrease to 26 having performed islet allotransplants in 2020. Notably, only 16 centers/networks have done >100 islet allotransplants in the survey period. Types of transplants performed differed notably between North America and the rest of the world, in particular with respect to the near-absence of simultaneous islet-kidney transplantation. Absence of heath care coverage has significantly hampered transplant activity in the past years and the COVID-19 pandemic in 2020.
A Research on the Evaluation of China’s Food Security under the Perspective of Sustainable Development—Based on an Entropy Weight TOPSIS Model
Authors: Zhang Xiaoyun , Wang Yu , Bao Jie , Wei Tengda , Xu Shiwei
Published: November 2022

Food safety is an important basis for promoting economic development, ensuring social stability and maintaining national security. Research on the evaluation of food security is the basis by which to accurately grasp the food security situation and to establish national food security policies in a scientific manner. Based on China’s agricultural economic data from 2001 to 2020, this research uses an entropy weight TOPSIS model to start from the new connotations and goals of food security in the new development stage, takes quantity security, structural security, ecological security of resources, economic security and policy security as the breakthrough points, builds a food security evaluation system containing 25 indicators, and aims to conduct evaluation and research on the evolution and current situation of China’s food security. The results show that China’s food security level drops first and then rises, that China attaches increasing importance to the ecological security and policy security of food resources, and that China’s food security level is restricted by such factors as resources, modes of production, circulation, storage, transportation, trade and structure. This article puts forward some policies and suggestions in terms of resources, technology and foreign trade to safeguard China’s food security.
Analysis of the Effect of Bivariate Fertilizer Discharger Control Sequence on Fertilizer Discharge Performance
Authors: Bu Haoran , Yu Siyao , Dong Wancheng , Zhang Lixin , Xia Yuanqing
Published: November 2022

Fertilization stability is an important index for evaluating the operational performance of variable fertilizer dischargers. To study the influence law of the combination of fertilizer discharge wheel rotational speed n and opening L on the fertilizer discharge performance, this paper firstly constructs a fertilizer amount prediction model based on a radial basis function neural network (RBFNN) through a calibration test, and after verification, its determination coefficient reaches 0.99965 with a mean relative error (MRE) of 3.88%. Then the discrete element simulation software (EDEM) was used to simulate the fertilizer discharge process under different control sequences for each of the three target fertilizer application amounts. The simulation results show that at the target fertilizer discharge rate of 944.92 g/min, when the control sequence is 18.3 r/min and 25 mm, the uniformity coefficient of variation (CV) of fertilizer discharge is the smallest. In the other control sequences, σ was higher than 20%, the stability of fertilizer discharge was poor, and the phenomenon of broken strips appeared; under the target fertilizer discharge rate of 2101.47 g/min, σ was the smallest at (24.2 r/min, 45 mm) 4.34%; under the target fertilizer discharge rate of 3842.87 g/min, σ was less than 4% in all cases, and at the control sequence (44.7 r/min, 45 mm), σ reached a minimum of 2.01%. Finally, using the simulation results and the prediction model of fertilizer amount based on RBFNN, the optimization model of fertilizer discharge control sequence based on the differential evolutionary (DE) algorithm was established, and a bench test was conducted to verify the optimization results, which showed that the accuracy and uniformity of fertilizer discharge met the operational requirements.
Impacts of the Inoculation of Piriformospora indica on Photosynthesis, Osmoregulatory Substances, and Antioxidant Enzymes of Alfalfa Seedlings under Cadmium Stress
Authors: Liu Bingqian , An Chunchun , Jiao Shuying , Jia Fengyuan , Liu Ruilin , Wu Qicong , Dong Zhi
Published: November 2022

With the random discharging of industrial and agricultural wastewater, a large amount of cadmium (Cd) has accumulated in the soil, which seriously affects the growth of crops and people’s food safety. In this study, alfalfa was used as the material for studying the effects of the inoculation of Piriformospora indica (P. indica) on photosynthesis, osmoregulatory substances, and antioxidant enzymes of alfalfa seedlings at different Cd concentrations (0, 5, 10, 30, 50, and 100 mg/L) through hydroponic experiments. The results showed that with the increase in Cd concentration, the chlorophyll content, net photosynthetic rate (Pn), transpiration rate (Tr), and stomatal conductance (Gs) of alfalfa all decreased gradually, while the intercellular CO2 concentration (Ci) decreased at first and then increased. However, compared with non-inoculated control plants, the inoculation of P. indica improved the photosynthesis (41.97%) of alfalfa under Cd stress, increased the chlorophyll content (43.70%), and significantly increased the contents of proline (29.86%), soluble proteins (38.54%), and antioxidant enzyme activities. It was concluded that P. indica alleviates the negative effects of Cd on alfalfa plants to some extent. This is because P. indica can resist Cd stress and improve plant growth in cadmium-contaminated agricultural soil by alleviating membrane peroxidation damage, regulating osmotic regulatory substances, and enhancing enzyme activity to improve the antioxidant defense system. Thus, P. indica can be considered a biological fertilizer for improving plant growth and physiology in soils contaminated with cadmium.