bluuebunny/crossref_metadata_2025 huggingface dataset:
Vehicle Energy Consumption in Python (VencoPy): Presenting and Demonstrating an Open-Source Tool to Calculate Electric Vehicle Charging Flexibility
Authors: Wulff Niklas , Miorelli Fabia , Gils Hans Christian , Jochem Patrick
Published: July 2021

As electric vehicle fleets grow, rising electric loads necessitate energy systems models to incorporate their respective demand and potential flexibility. Recently, a small number of tools for electric vehicle demand and flexibility modeling have been released under open source licenses. These usually sample discrete trips based on aggregate mobility statistics. However, the full range of variables of travel surveys cannot be accessed in this way and sub-national mobility patterns cannot be modeled. Therefore, a tool is proposed to estimate future electric vehicle fleet charging flexibility while being able to directly access detailed survey results. The framework is applied in a case study involving two recent German national travel surveys (from the years 2008 and 2017) to exemplify the implications of different mobility patterns of motorized individual vehicles on load shifting potential of electric vehicle fleets. The results show that different mobility patterns, have a significant impact on the resulting load flexibilites. Most obviously, an increased daily mileage results in higher electricty demand. A reduced number of trips per day, on the other hand, leads to correspondingly higher grid connectivity of the vehicle fleet. VencoPy is an open source, well-documented and maintained tool, capable of assessing electric vehicle fleet scenarios based on national travel surveys. To scrutinize the tool, a validation of the simulated charging by empirically observed electric vehicle fleet charging is advised.
Growing Stock Volume Retrieval from Single and Multi-Frequency Radar Backscatter
Authors: Tanase Mihai A. , Borlaf-Mena Ignacio , Santoro Maurizio , Aponte Cristina , Marin Gheorghe , Apostol Bogdan , Badea Ovidiu
Published: July 2021

While products generated at global levels provide easy access to information on forest growing stock volume (GSV), their use at regional to national levels is limited by temporal frequency, spatial resolution, or unknown local errors that may be overcome through locally calibrated products. This study assessed the need, and utility, of developing locally calibrated GSV products for the Romanian forests. To this end, we used national forest inventory (NFI) permanent sampling plots with largely concurrent SAR datasets acquired at C- and L-bands to train and validate a machine learning algorithm. Different configurations of independent variables were evaluated to assess potential synergies between C- and L-band. The results show that GSV estimation errors at C- and L-band were rather similar, relative root mean squared errors (RelRMSE) around 55% for forests averaging over 450 m3 ha−1, while synergies between the two wavelengths were limited. Locally calibrated models improved GSV estimation by 14% when compared to values obtained from global datasets. However, even the locally calibrated models showed particularly large errors over low GSV intervals. Aggregating the results over larger areas considerably reduced (down to 25%) the relative estimation errors.
Native or Invasive? The Red-Haired Pine Bark Beetle Hylurgus ligniperda (Fabricius) (Curculionidae: Scolytinae) in East Asia
Authors: Lin Wei , Park Sangwook , Jiang Zi-Ru , Ji Ying-Chao , Ernstsons Andris Simon , Li Jun-Jun , Li You , Hulcr Jiri
Published: July 2021

The red-haired pine bark beetle, Hylurgus ligniperda (Fabricius), is one of the most rapidly spreading invasive forest insects. Originally from Eurasia, it has subsequently been introduced to Oceania, North, and South America. Yet, the status of H. ligniperda in East Asia is ambiguous. Here, investigation and analysis were conducted on the beetle in China, South Korea, and Japan. New occurrences in China and South Korea were recorded by field surveys and the expansion of H. ligniperda spreading in East Asia was analyzed. The results show that H. ligniperda is likely an invasive species in East Asia, initially invading Japan, then South Korea. Now it has invaded and successfully colonized Shandong province, China. Furthermore, the species has spread rapidly and it is now widely distributed in South Korea and Japan.
Bored Coffee Beans for Production of Hyaluronic Acid by Streptococcus zooepidemicus
Authors: Flores-Méndez David Antonio , Ramos-Ibarra José Roberto , Toriz Guillermo , Arriola-Guevara Enrique , Guatemala-Morales Guadalupe , Corona-González Rosa Isela
Published: July 2021

Bored coffee beans (BCBs) are the residues left from the pest Hypothenemus hampei that attacks coffee crops, resulting in enormous economic losses. The bioconversion of monosaccharides from BCBs into hyaluronic acid (HA) is appealing both for using the residues and given the high commercial value of HA. This study dealt with the production of HA using Streptococcus zooepidemicus by employing either acid (AcH) or enzymatic (EnH) hydrolyzates from BCBs. The highest release of monosaccharides (evaluated using surface response methodology) was obtained with EnH (36.4 g/L); however, S. zooepidemicus produced more HA (1.5 g/L) using AcH compared to EnH. Hydrolyzates from acetone-extracted BCBs yielded 2.7 g/L of HA, which is similar to the amount obtained using a synthetic medium (2.8 g/L). This report demonstrates the potential of hydrolyzates from bored coffee beans to produce HA by S. zooepidemicus.
Real-Time Simulation of Parameter-Dependent Fluid Flows through Deep Learning-Based Reduced Order Models
Authors: Fresca Stefania , Manzoni Andrea
Published: July 2021

Simulating fluid flows in different virtual scenarios is of key importance in engineering applications. However, high-fidelity, full-order models relying, e.g., on the finite element method, are unaffordable whenever fluid flows must be simulated in almost real-time. Reduced order models (ROMs) relying, e.g., on proper orthogonal decomposition (POD) provide reliable approximations to parameter-dependent fluid dynamics problems in rapid times. However, they might require expensive hyper-reduction strategies for handling parameterized nonlinear terms, and enriched reduced spaces (or Petrov–Galerkin projections) if a mixed velocity–pressure formulation is considered, possibly hampering the evaluation of reliable solutions in real-time. Dealing with fluid–structure interactions entails even greater difficulties. The proposed deep learning (DL)-based ROMs overcome all these limitations by learning, in a nonintrusive way, both the nonlinear trial manifold and the reduced dynamics. To do so, they rely on deep neural networks, after performing a former dimensionality reduction through POD, enhancing their training times substantially. The resulting POD-DL-ROMs are shown to provide accurate results in almost real-time for the flow around a cylinder benchmark, the fluid–structure interaction between an elastic beam attached to a fixed, rigid block and a laminar incompressible flow, and the blood flow in a cerebral aneurysm.
Lactic Acid Bacteria Exopolysaccharides Producers: A Sustainable Tool for Functional Foods
Authors: Prete Roberta , Alam Mohammad Khairul , Perpetuini Giorgia , Perla Carlo , Pittia Paola , Corsetti Aldo
Published: July 2021

Lactic acid bacteria (LAB) used in the food industry, mainly for the production of dairy products, are able to synthetize exopolysaccharides (EPS). EPS play a central role in the assessment of rheological and sensory characteristics of dairy products since they positively influence texture and organoleptic properties. Besides these, EPS have gained relevant interest for pharmacological and nutraceutical applications due to their biocompatibility, non-toxicity and biodegradability. These bioactive compounds may act as antioxidant, cholesterol-lowering, antimicrobial and prebiotic agents. This review provides an overview of exopolysaccharide-producing LAB, with an insight on the factors affecting EPS production, their dairy industrial applications and health benefits.
Optimization and Development of Ready to Eat Chocolate Coated Roasted Flaked Rice as Instant Breakfast Food
Authors: Kumar Shiv , Baniwal Poonam , Nayik Gulzar Ahmad , Prasad Kamlesh , Khan Khalid Ali , Ghramh Hamed A. , Kumar Harish , Karabagias Ioannis Konstantinos
Published: July 2021

The present study aimed to optimize and develop ready-to-eat rice-based functional breakfast food using response surface methodology. The levels of ingredients viz. skim milk powder, guar gum, and ferrous sulfate were pre-optimized and remained constant, whereas jaggery and dark chocolate were taken as independent variables. The optimum levels of jaggery and dark chocolate for chocolate-coated roasted flaked rice (CCRFR) were 8.49 g and 25.43 g, respectively. The physical, pasting, textural, functional, morphological, optical, and sensory characteristics of CCRFR and uncoated roasted flaked rice (RFR) were also studied. CCRFR had significantly higher mineral (iron and calcium) and total polyphenolic contents. Furthermore, the dimensional, sensory, and functional properties were also improved. The changes in morphological structure were also observed between the CCRFR and uncoated product using scanning electron microscopy. The coating adds nutritional value to the roasted rice and renders it an essential functional RTE convenience gluten-free cereal breakfast item.
Energy Content and Nutrient Profiles of Frequently Consumed Meals in Singapore
Authors: Yeo Penny Liu Qing , Bi Xinyan , Yeo Michelle Ting Yun , Henry Christiani Jeyakumar
Published: July 2021

Singapore is a multi-ethnic country with a great variety of traditional ethnic cuisines. In this modern society where there is an increasing prevalence of obesity, it is important to know the nutritional content and energy density of our foods. However, there have been little data on the nutritional content of our local foods. The energy density and nutrient content of 45 commonly consumed meals by three ethnic groups in Singapore (Chinese, Malay, and Indian) were assessed in this study. Chinese, Malay, and Indian cuisines had an average energy density of 661, 652, and 723 kJ/100 g, respectively. Moreover, the macronutrient content is different between the different ethnic groups. Compared to Chinese and Malay cuisines, Indian cuisine contained lower protein but higher fat and carbohydrate content (p = 0.03). From the mineral analysis of the ethnic foods, we found out that Chinese cuisines contain significantly higher sodium (average of 238 mg/100 g) than Malay cuisines (p = 0.006) and Indian cuisines (p = 0.03). Knowing the caloric density and nutrition content of local ethnic foods may aid hawkers and government officials in developing healthier options to tackle Singapore’s obesity epidemic.
Lévy Processes Linked to the Lower-Incomplete Gamma Function
Authors: Beghin Luisa , Ricciuti Costantino
Published: July 2021

We start by defining a subordinator by means of the lower-incomplete gamma function. This can be considered as an approximation of the stable subordinator, easier to be handled in view of its finite activity. A tempered version is also considered in order to overcome the drawback of infinite moments. Then, we study Lévy processes that are time-changed by these subordinators with particular attention to the Brownian case. An approximation of the fractional derivative (as well as of the fractional power of operators) arises from the analysis of governing equations. Finally, we show that time-changing the fractional Brownian motion produces a model of anomalous diffusion, which exhibits a sub-diffusive behavior.
The Colonial Project of Gender (and Everything Else)
Authors: O’Sullivan Sandy
Published: July 2021

The gender binary, like many colonial acts, remains trapped within socio-religious ideals of colonisation that then frame ongoing relationships and restrict the existence of Indigenous peoples. In this article, the colonial project of denying difference in gender and gender diversity within Indigenous peoples is explored as a complex erasure casting aside every aspect of identity and replacing it with a simulacrum of the coloniser. In examining these erasures, this article explores how diverse Indigenous gender presentations remain incomprehensible to the colonial mind, and how reinstatements of kinship and truth in representation fundamentally supports First Nations’ agency by challenging colonial reductions. This article focuses on why these colonial practices were deemed necessary at the time of invasion, and how they continue to be forcefully applied in managing Indigenous peoples into a colonial structure of family, gender, and everything else.
A Large-Scale Genome-Wide Association Study of Epistasis Effects of Production Traits and Daughter Pregnancy Rate in U.S. Holstein Cattle
Authors: Prakapenka Dzianis , Liang Zuoxiang , Jiang Jicai , Ma Li , Da Yang
Published: July 2021

Epistasis is widely considered important, but epistasis studies lag those of SNP effects. Genome-wide association study (GWAS) using 76,109 SNPs and 294,079 first-lactation Holstein cows was conducted for testing pairwise epistasis effects of five production traits and three fertility traits: milk yield (MY), fat yield (FY), protein yield (PY), fat percentage (FPC), protein percentage (PPC), and daughter pregnancy rate (DPR). Among the top 50,000 pairwise epistasis effects of each trait, the five production traits had large chromosome regions with intra-chromosome epistasis. The percentage of inter-chromosome epistasis effects was 1.9% for FPC, 1.6% for PPC, 10.6% for MY, 29.9% for FY, 39.3% for PY, and 84.2% for DPR. Of the 50,000 epistasis effects, the number of significant effects with log10(1/p) ≥ 12 was 50,000 for FPC and PPC, and 10,508, 4763, 4637 and 1 for MY, FY, PY and DPR, respectively, and A × A effects were the most frequent epistasis effects for all traits. Majority of the inter-chromosome epistasis effects of FPC across all chromosomes involved a Chr14 region containing DGAT1, indicating a potential regulatory role of this Chr14 region affecting all chromosomes for FPC. The epistasis results provided new understanding about the genetic mechanism underlying quantitative traits in Holstein cattle.
Lessons Learned from Introducing Last Aid Courses at a University Hospital in Germany
Authors: Mueller Evelyn , Bollig Georg , Becker Gerhild , Boehlke Christopher
Published: July 2021

In recent years, so called “Last Aid courses”, concerning end-of-life care for people dying, have successfully been established in community settings in several European countries, Australia, and South-America. To date, they have not been evaluated in hospital settings, where educational needs (concerning care of the dying) are especially high, and may differ from the general population. To evaluate if Last Aid courses are feasible in hospital settings, and if informational needs of hospital staff are met by the curriculum, we introduced Last Aid courses at a university hospital. Five courses were offered; participants of courses 1 and 2 completed surveys with open-ended questions; the answers were used to develop the evaluation questionnaire employed in courses 3–5. In these three courses, 55 of the 56 participants completed an evaluation survey to explore their learning goals and obtain feedback. Courses were fully booked; participants were heterogeneous with regard to their professional background. The most prevalent learning goals were “preparation for emotional aspects in care of dying” (65.5% ratings “very important”), “preparation for medical/care aspects in care of dying” (60.0%), and “knowledge of supportive services and facilities” (54.5%). Overall, the evaluation showed that Last Aid courses were more suitable to educate non-medical hospital staff about care of the dying. Medical staff, in contrast to non-medical staff, more often requested courses with an extended curriculum in order to meet their learning goals. Last Aid courses were well accepted and helped to reduce information deficits on care of the dying in a heterogeneous population of hospital staff.
Knowledge, Perception, and Performance of Hand Hygiene and Their Correlation among Nursing Students in Republic of Korea
Authors: Oh Hyang Soon
Published: July 2021

Recently, various outbreaks of newly emerging or reemerging diseases are expected more frequently and regularly. The importance of hand hygiene (HH) competency of nursing students (NS) is further required as a crucial learning objective of nursing education in universities. Purpose: This study aimed to investigate knowledge, perception, and performance of HH among NS and analyze their correlation. Methods: A cross-sectional questionnaire (modified from a World Health Organization questionnaire) was conducted from 23 November to 22 December 2019; 233 responses were used for the final analysis. Results: The average scores (mean ± standard deviation (range)) for knowledge, perception, and performance of HH were 17.82 ± 2.15 (0–25), 77.24 ± 10.78 (15–96), and 67.42 ± 23.10 (0–100), respectively. No significant variables were discovered to the knowledge of HH. Grade, university-affiliated hospitals, and the most recent healthcare institute of clinical practice nursing course significantly affected perceptions of HH (p < 0.039, p = 044, p < 0.001). Knowledge of HH was positively correlated with performance of HH (p = 0.002). The perception and the performance of HH of NS were positively correlated with HH performance of healthcare workers (HCWs); p < 0.001, p = 0.002. Conclusion: HH education for NS is crucial for improving the performance and the knowledge of HH. Good HH performance of healthcare workers (HCWs) can contribute to increased perception and performance of HH among NS. The cooperation of nursing education in a university and clinical practice with competent HCWs in healthcare institutions may create an effective education program for good HH performance of NS, who will be nurses during unpredictable pandemics.
Influence of Flue Gas Desulfurization Gypsum on Phosphorus Loss from a Horticultural Growth Medium
Authors: Watts Dexter Brown , Runion George Brett , Torbert Henry Allen
Published: July 2021

In response to agriculture’s contribution to surface water quality, considerable effort is being made to develop best management practices to reduce nutrient loss. To evaluate the efficacy of gypsum as a horticultural media amendment for controlling phosphorus (P) leaching, flue gas desulfurization (FGD) gypsum was added to a standard horticultural growth medium at 0, 2.5, 5, 10 or 15% (v/v). FGD gypsum was either mixed with the growing medium or placed at the bottom of the containers. A fast-release or a control-release fertilizer was top-dressed to containers. The greatest P leaching occurred with the fertilizer-only treatments (no gypsum). Dissolved reactive P (DRP) losses were highest on the initial day of measurement for the fast-release fertilizer and then decreased rapidly. There was a delayed release of DRP from the controlled-release fertilizer. Increasing rates of FGD gypsum addition resulted in decreasing DRP leaching concentration loss and load. The FGD gypsum decreased leachate DRP concentration loss by a maximum of 75%, with an average decrease of 46%. Mixing the FGD gypsum with the medium (an easier/less expensive means of incorporation) was most effective with the fast-release fertilizer. These preliminary results indicate that less gypsum may be needed to reduce P loss from fast-released fertilizer as opposed to control-release fertilizer. FGD gypsum remained effective in reducing DRP loss throughout the experiment.
Optical Characteristics of Greenhouse Plastic Films Affect Yield and Some Quality Traits of Spinach (Spinacia oleracea L.) Subjected to Different Nitrogen Doses
Authors: Mola Ida Di , Ottaiano Lucia , Cozzolino Eugenio , Sabatino Leo , Sifola Maria Isabella , Mormile Pasquale , El-Nakhel Christophe , Rouphael Youssef , Mori Mauro
Published: July 2021

Light and nitrogen strongly affect the growth, yield, and quality of food crops, with greater importance in green leafy vegetables for their tendency to accumulate nitrate in leaves. The purpose of this research was to explore the effect of two greenhouse films (Film A and B) on yield, and quality of spinach grown under different nitrogen regimes (not fertilized—N0%; sub-optimal N dose—N50%; optimal N dose—N100%). Film A and Film B were used as clear and diffused light films, with 75% and 87% thermicity, and 85% and 90% total transmittivity, respectively, where only Film B had a UV-B window. Film B elicited an increase in yield (22%) and soil–plant analysis development (SPAD) index (4.6%) compared to the clear film, but did not affect chlorophyll a, b, and total chlorophyll content. In addition, the diffuse film significantly decreased ascorbic acid in the crop but had no effect on lipophilic antioxidant activity and phenols content, but decreased ascorbic acid content. Finally, nitrate content was strongly increased both by nitrogen dose (about 50-fold more than N0%) and greenhouse films (about six-fold higher under diffuse light film), but within the legal limit fixed by European Commission. Therefore, irrespective of N levels, the use of diffuse-light film in winter boosts spinach yield without depressing quality.
Staphylococcus aureus Biofilm: Morphology, Genetics, Pathogenesis and Treatment Strategies
Authors: Idrees Muhammad , Sawant Sheeba , Karodia Nazira , Rahman Ayesha
Published: July 2021

Staphylococcus aureus is a nosocomial bacterium causing different infectious diseases, ranging from skin and soft tissue infections to more serious and life-threatening infections such as septicaemia. S. aureus forms a complex structure of extracellular polymeric biofilm that provides a fully secured and functional environment for the formation of microcolonies, their sustenance and recolonization of sessile cells after its dispersal. Staphylococcus aureus biofilm protects the cells against hostile conditions, i.e., changes in temperature, limitations or deprivation of nutrients and dehydration, and, more importantly, protects the cells against antibacterial drugs. Drugs are increasingly becoming partially or fully inactive against S. aureus as they are either less penetrable or totally impenetrable due to the presence of biofilms surrounding the bacterial cells. Other factors, such as evasion of innate host immune system, genome plasticity and adaptability through gene evolution and exchange of genetic material, also contribute to the ineffectiveness of antibacterial drugs. This increasing tolerance to antibiotics has contributed to the emergence and rise of antimicrobial resistance (AMR), a serious problem that has resulted in increased morbidity and mortality of human and animal populations globally, in addition to causing huge financial losses to the global economy. The purpose of this review is to highlight different aspects of S. aureus biofilm formation and its overall architecture, individual biofilm constituents, clinical implications and role in pathogenesis and drug resistance. The review also discusses different techniques used in the qualitative and quantitative investigation of S. aureus biofilm and various strategies that can be employed to inhibit and eradicate S. aureus biofilm.
Influence of Tunneled Hemodialysis-Catheters on Inflammation and Mortality in Dialyzed Patients
Authors: Crespo-Montero Rodolfo , Gómez-López Victoria E. , Guerrero-Pavón Fátima , Carmona-Muñoz Andrés , Romero-Saldaña Manuel , Ranchal-Sanchez Antonio , Aljama-García Pedro
Published: July 2021

Older age and comorbidities in hemodialysis patients determines the use of tunneled catheters as vascular access despite their reported clinical and mortality disadvantages. This prospective matched study analyzes the impact of permanent catheters on inflammation and mortality in hemodialysis patients; We studied 108 patients, 54 with AV-fistula (AVF) and 54 with indwelling hemodialysis catheters (HDC) matched by sex, age, diabetes and time under renal-replacement therapy comparing dialysis efficacy, inflammation and micro-inflammation parameters as well as mortality. Cox-regression analysis was applied to determine predictors of mortality, HDC patients presented higher C-reactive-protein (CRP) blood levels and percentage of pro-inflammatory lymphocytes CD14+/CD16+ with worse dialysis-efficacy parameters. Thirty-six-months mortality appeared higher in the HDC group although statistical significance was not reached. Age with a Hazard Ratio (HR) = 1.06, hypoalbuminemia (HR = 0.43), hypophosphatemia (HR = 0.75) and the increase in CD14+/CD16+ monocyte count (HR = 1.02) were predictors of mortality; elder patients dialyzing through HDC show increased inflammation parameters as compared with nAVF bearing patients, although they do not present a significant increase in mortality when matched by covariates. Increasing age and percentage of pro-inflammatory monocytes as well as decreased phosphate and serum-albumin were predictors of mortality and indicate the main conclusions or interpretations.
Feasibility of Multicomponent Training for People with Moderate to Severe Dementia Living in a Long-Term Care Home: A Social Ethical Approach
Authors: Kruse Adele , Cordes Thomas , Schulz Steffen , Wollesen Bettina
Published: July 2021

Multicomponent training is recommended for people with dementia living in long-term care homes. Nevertheless, evidence is limited and people with severe dementia are often excluded from trials. Hence, the aim of this study was to investigate (1) the feasibility and (2) the requirements regarding multicomponent training for people with moderate to severe dementia. The study was conducted as an uncontrolled single arm pilot study with a mixed methods approach. Fifteen nursing home residents with a mean age of 82 years (range: 75–90 years; female: 64%) with moderate to severe dementia received 16 weeks of multicomponent training. Feasibility and requirements of the training were assessed by a standardized observation protocol. Eleven participants regularly attended the intervention. The highest active participation was observed during gait exercises (64%), the lowest during strength exercises (33%). It was supportive if exercises were task-specific or related to everyday life. This study confirms that multicomponent training for the target group is (1) feasible and well accepted, and (2) to enhance active participation, individual instructions and the implementation of exercises related to everyday life is required. The effectiveness of the adapted training should be tested in future randomized controlled trials.
Analysis of Home-Based Rehabilitation Awareness, Needs and Preferred Components of Elderly Patients with Hip Fracture Surgery in South Korea
Authors: Lee Haneul , Lee Seon-Heui
Published: July 2021

The importance and necessity of home-based rehabilitation with professional and systematic interventions should be considered since home-based rehabilitation has been institutionalized as it is more feasible, cost effective, and even safer than in-hospital rehabilitation in most countries—though not in South Korea. In addition, the need for home-based rehabilitation is increasing due to the increasing number of hip fracture patients and limited capacity of acute hospital rehabilitation. Therefore, the purpose of this study was to investigate the awareness, needs, and preferred components of home-based rehabilitation services after discharge for elderly patients with hip fracture surgery in South Korea. A survey of 98 elderly patients who recently underwent hip fracture surgery was performed using a questionnaire. More than 75% of patients agreed on the need for home-based rehabilitation, even though most had never heard of it. The reason for the need for home-based rehabilitation was that it is possible to receive continuously ongoing treatment (53.0%), and it alleviates the inconvenience of visiting hospitals (27.7%). In addition to this, about 15.7% of patients responded that they could achieve mental comfort. In other words, patients can recover in an emotionally stable environment without the psychological anxiety they might experience in hospital. Thus, in order to maximize the effectiveness of home-based rehabilitation and provide comprehensive guidance including exercise, education, motivational support, and environmental modification, to patients undergoing hip fracture surgery, the component of the rehabilitation program must be developed based upon rehabilitation experts’ knowledge and patients’ value. Additionally, corresponding policies should be established.
The Causes of Occupational Accidents and Injuries in Romanian Firms: An Application of the Johansen Cointegration and Granger Causality Test
Authors: Ivascu Larisa , Sarfraz Muddassar , Mohsin Muhammad , Naseem Sobia , Ozturk Ilknur
Published: July 2021

Organizational risks are present in any activity, so it is important to manage them properly. The jobs are dynamic and involve a series of processes and activities. The entire human resource is exposed to several risks. If these risks are approached correctly, the organizational capacity to achieve its objectives and vision will increase considerably. This paper aims to investigate the relationships between work accidents (fatal and non-fatal) and the causes that contribute to their occurrence (causes dependent on the executor, causes dependent on the means of production, workload-dependent causes, and work-dependent causes—the work environment). The augmented Dickey–Fuller (ADF) test is employed to check the data stationarity series, while the Johansen test determines the cointegration relation of variables. The data have been collected from Romanian organizations. The vector error correction model (VECM) and Granger causality test are applied for speed of adjustment, nature, and direction of variables’ relationship. This research demonstrated that both data series are free from the unit-root problem at first difference. The lag length criterions select the third lag for model fitness, and Johansen cointegration declares that variables are cointegrated for the long term. The vector error correction model shows the speed of adjustment from the short to the long run is 83.35% and 42.60% for work and fatal accidents. The study results show that fatal accidents have a series relationship with selected cases for the short run and have a long-run relationship with the means of production. Fatal accidents are directly related to means of production. Fatal accidents are not designed by executors, workload-dependent causes, or work environments in the short run. Fatal accidents are directly related to the means of production and sudden incidents happening in the long run. Fatal accidents are considered by executors, workload-dependent causes, or work environments in the short run. In the long run, fatal accidents are directly related to the means of production and sudden incidents happening.
Neighborhood-Level Influences and Adolescent Health Risk Behaviors in Rural and Urban Sub-Saharan Africa: A Systematic Review
Authors: Wiafe Stephanie , Mihan Ariana , Davison Colleen M.
Published: July 2021

The impact of neighborhoods on adolescent engagement in health-risk behaviors (HRBs), such as substance use and sexual activity, has been well documented in high-income countries; however, evidence from low and middle-income country settings is limited, particularly in sub-Saharan African (SSA) countries. Neighborhoods and communities in SSA continue to experience urbanization, epidemiologic transition, and the simultaneous presence of large populations living in rurality and urbanicity. This is a dynamic context for exploring adolescent health challenges. This review seeks to identify and summarize existing literature that investigates adolescent engagement in HRBs when compared across rural and urban neighborhoods across SSA. We performed searches using three electronic databases, targeted grey literature searches and scanned reference lists of included studies. Following dual-screening, our search yielded 23 relevant studies that met all inclusion criteria. These were categorized into six broad themes including studies on: (1) sexual risk taking, (2) injury-related, (3) violence, (4) eating and/or exercise-related, (5) substance use, and (6) personal hygiene. We found that neighborhood factors relating to accessibility and availability of health information and care impacted adolescent engagement in HRBs in rural and urban areas. Urbanization of areas of SSA plays a role in differences in engagement in HRBs between rural and urban dwelling adolescents.
Acculturation, Health Behaviors, and Social Relations among Chinese Immigrants Living in Spain
Authors: Badanta Barbara , Vega-Escaño Juan , Barrientos-Trigo Sergio , Tarriño-Concejero Lorena , García-Carpintero Muñoz María Ángeles García-Carpintero , González-Cano-Caballero María , Barbero-Radío Antonio , de-Pedro-Jimenez Domingo , Lucchetti Giancarlo , de Diego-Cordero Rocío
Published: July 2021

This study aims to identify acculturation experiences about social relations and health behaviors of first-generation Chinese immigrants in the South of Spain, including food patterns, physical exercise, and tobacco and alcohol use. A phenomenological qualitative study was conducted using semi-structured interviews, informal conversations, and field notes. All data were analyzed under the Berry’s Model of Acculturation. A total of 133 Chinese immigrants were included. Our findings show that separation was the dominant acculturation strategy, followed by integration and assimilation, while marginalization was not present in this immigrant population. Most of the immigrant population maintains a link to the customs of their home country, favoring the process of identity and collective self-esteem. These results can help health managers and the government to further understand Chinese immigrants in Europe and to establish appropriate health interventions to this group.
Physical Activity Barriers and Assets in Rural Appalachian Kentucky: A Mixed-Methods Study
Authors: Jones Natalie , Dlugonski Deirdre , Gillespie Rachel , DeWitt Emily , Lianekhammy Joann , Slone Stacey , Cardarelli Kathryn M.
Published: July 2021

Obesity is an increasing public health concern in the U.S. and a contributor to chronic illness, with trends revealing a rise in adult obesity and chronic disease rates among the most vulnerable and disadvantaged populations, including those in rural communities. A mixed-methods approach was used to examine perspectives on perceived physical activity barriers, resources, and level of community support. Researchers utilized the socioecological model to examine the multiple domains that support physical activity in rural Appalachia. The present study focuses on baseline data, including a cohort survey to assess physical activity, health status, and barriers to physical activity, and five focus groups with elected community leaders, community residents, members, and key stakeholders to assess perspectives on physical activity barriers and resources within the county. The cohort survey sample (N = 152) reported a median of 6 barriers (range 0–13) to participating in at least 30 min of physical activity daily. The qualitative analysis yielded three overarching themes related to physical activity participation: lack of motivation, physical environment, and cultural barriers. This mixed-methods study revealed the challenges and perceptions among rural residents across the socioecological model when assessing physical inactivity. Findings can be used to tailor future interventions focused on expanding social support, designing infrastructure, and creating policies that promote physical activity.
Costs Associated with the Treatment of Clostridioides Difficile Infections
Authors: Sierocka Aleksandra , Kiersnowska Zofia , Lemiech-Mirowska Ewelina , Marczak Michał
Published: July 2021

Background: Clostridioides difficile, as the main cause of infectious diarrhoea in hospitalised patients, is a considerable challenge for medical personnel (hospital environment) who have direct contact with the patient, as well as being of interest to public health specialists. Financial issues related to the occurrence of the above-mentioned micro-organism are being increasingly raised. Due to the scale of the phenomenon, we are beginning to pay attention to the significant system costs caused by the diagnosis and treatment of CDI infection and its complications. Studies indicate that the nosocomial infection of C. difficile complicates hospitalisation, by increasing the cost by more than half and extending patient’s stay by an average of 3.6 days. Material and methods: The aim of this study was to attempt to calculate the estimated costs associated with the prolonged hospitalisation of patients with nosocomial CDI infection, using the example of a hospital in Lodz. A total of 53 completed hospitalisations of patients treated in the period of January–August 2018 were analysed, during which hospital Clostridioides difficile infection was identified. For the purposes of this study, statistical data collected in the hospital’s IT system were also analysed, covering 44,868 hospitalisations in the Jan–Aug 2018 period, during which no hospital infection occurred. They was a control group, in which the analysed cases were compared. The obtained data in the study determined how long each patient with Clostridioides difficile infection stayed in the hospital (from the moment infection was diagnosed until the day of hospital discharge), and which diagnosis related groups (DRG) (according to National Health Fund guidelines) were assigned. The average length of patient stay without infection within a given DRG group in each hospital ward was also determined. The collected materials became the initial point for the final analysis of hospital costs and the length of hospital stay caused by Clostridioides difficile infection. Results: Clostridioides difficile infection extended the hospital stay by an average of almost 12 days. The average cost of prolonged hospitalisation due to CDI infection (according to the average cost per person-day) was about PLN 7148 (1664 EUR), which gave a total value of about PLN 378,860.6 (88,240.5 EUR) in the examined period. At the same time, the average expenditure from the National Health Fund for hospitalisation due to CDI infections increased by about PLN 6627 (1542.8 EUR), which in the analysed period translated into over PLN 351,232.0 (81,505.5 EUR) (according to settlements with the National Health Fund). The outcome indicates that there is a clear relation between CDI and the anticipated length of hospitalisation of patients without an infection.
How Artificial Intelligence and New Technologies Can Help the Management of the COVID-19 Pandemic
Authors: Barbieri Davide , Giuliani Enrico , Del Prete Anna , Losi Amanda , Villani Matteo , Barbieri Alberto
Published: July 2021

The COVID-19 pandemic has worked as a catalyst, pushing governments, private companies, and healthcare facilities to design, develop, and adopt innovative solutions to control it, as is often the case when people are driven by necessity. After 18 months since the first case, it is time to think about the pros and cons of such technologies, including artificial intelligence—which is probably the most complex and misunderstood by non-specialists—in order to get the most out of them, and to suggest future improvements and proper adoption. The aim of this narrative review was to select the relevant papers that directly address the adoption of artificial intelligence and new technologies in the management of pandemics and communicable diseases such as SARS-CoV-2: environmental measures; acquisition and sharing of knowledge in the general population and among clinicians; development and management of drugs and vaccines; remote psychological support of patients; remote monitoring, diagnosis, and follow-up; and maximization and rationalization of human and material resources in the hospital environment.
How Are the Links between Alcohol Consumption and Breast Cancer Portrayed in Australian Newspapers?: A Paired Thematic and Framing Media Analysis
Authors: Rudge Amy , Foley Kristen , Lunnay Belinda , Miller Emma R. , Batchelor Samantha , Ward Paul R.
Published: July 2021

A dose-dependent relationship between alcohol consumption and increased breast cancer risk is well established, even at low levels of consumption. Australian women in midlife (45–64 years) are at highest lifetime risk for developing breast cancer but demonstrate low awareness of this link. We explore women’s exposure to messages about alcohol and breast cancer in Australian print media in the period 2002–2018. Methods: Paired thematic and framing analyses were undertaken of Australian print media from three time-defined subsamples: 2002–2004, 2009–2011, and 2016–2018. Results: Five key themes arose from the thematic framing analysis: Ascribing Blame, Individual Responsibility, Cultural Entrenchment, False Equilibrium, and Recognition of Population Impact. The framing analysis showed that the alcohol–breast cancer link was predominantly framed as a behavioural concern, neglecting medical and societal frames. Discussion: We explore the representations of the alcohol and breast cancer risk relationship. We found their portrayal to be conflicting and unbalanced at times and tended to emphasise individual choice and responsibility in modifying health behaviours. We argue that key stakeholders including government, public health, and media should accept shared responsibility for increasing awareness of the alcohol–breast cancer link and invite media advocates to assist with brokering correct public health information.
Phased Implementation of COVID-19 Vaccination: Rapid Assessment of Policy Adoption, Reach and Effectiveness to Protect the Most Vulnerable in the US
Authors: Li Yun , Li Moming , Rice Megan , Su Yanfang , Yang Chaowei
Published: July 2021

The US and the rest of the world have suffered from the COVID-19 pandemic for over a year. The high transmissibility and severity of this virus have provoked governments to adopt a variety of mitigation strategies. Some of these previous measures, such as social distancing and mask mandates, were effective in reducing the case growth rate yet became economically and administratively difficult to enforce as the pandemic continued. In late December 2020, COVID-19 vaccines were first approved in the US and states began a phased implementation of COVID-19 vaccination. However, there is limited quantitative evidence regarding the effectiveness of the phased COVID-19 vaccination. This study aims to provide a rapid assessment of the adoption, reach, and effectiveness of the phased implementation of COVID-19 vaccination. We utilize an event-study analysis to evaluate the effect of vaccination on the state-level daily COVID-19 case growth rate. Through this analysis, we assert that vaccination was effective in reducing the spread of COVID-19 shortly after the first shots were given. Specifically, the case growth rate declined by 0.124, 0.347, 0.345, 0.464, 0.490, and 0.756 percentage points corresponding to the 1–5, 6–10, 11–15, 16–20, 21–25, and 26 or more day periods after the initial shots. The findings could be insightful for policymakers as they work to optimize vaccine distribution in later phases, and also for the public as the COVID-19 related health risk is a contentious issue.
Btk Inhibitors: A Medicinal Chemistry and Drug Delivery Perspective
Authors: Brullo Chiara , Villa Carla , Tasso Bruno , Russo Eleonora , Spallarossa Andrea
Published: July 2021

In the past few years, Bruton’s tyrosine Kinase (Btk) has emerged as new target in medicinal chemistry. Since approval of ibrutinib in 2013 for treatment of different hematological cancers (as leukemias and lymphomas), two other irreversible Btk inhibitors have been launched on the market. In the attempt to overcome irreversible Btk inhibitor limitations, reversible compounds have been developed and are currently under evaluation. In recent years, many Btk inhibitors have been patented and reported in the literature. In this review, we summarized the (ir)reversible Btk inhibitors recently developed and studied clinical trials and preclinical investigations for malignancies, chronic inflammation conditions and SARS-CoV-2 infection, covering advances in the field of medicinal chemistry. Furthermore, the nanoformulations studied to increase ibrutinib bioavailability are reported.
CD73 Overexpression in Podocytes: A Novel Marker of Podocyte Injury in Human Kidney Disease
Authors: Popovic Zoran V. , Bestvater Felix , Krunic Damir , Krämer Bernhard K. , Bergner Raoul , Löffler Christian , Hocher Berthold , Marx Alexander , Porubsky Stefan
Published: July 2021

The CD73 pathway is an important anti-inflammatory mechanism in various disease settings. Observations in mouse models suggested that CD73 might have a protective role in kidney damage; however, no direct evidence of its role in human kidney disease has been described to date. Here, we hypothesized that podocyte injury in human kidney diseases alters CD73 expression that may facilitate the diagnosis of podocytopathies. We assessed the expression of CD73 and one of its functionally important targets, the C-C chemokine receptor type 2 (CCR2), in podocytes from kidney biopsies of 39 patients with podocytopathy (including focal segmental glomerulosclerosis (FSGS), minimal change disease (MCD), membranous glomerulonephritis (MGN) and amyloidosis) and a control group. Podocyte CD73 expression in each of the disease groups was significantly increased in comparison to controls (p < 0.001–p < 0.0001). Moreover, there was a marked negative correlation between CD73 and CCR2 expression, as confirmed by immunohistochemistry and immunofluorescence (Pearson r = −0.5068, p = 0.0031; Pearson r = −0.4705, p = 0.0313, respectively), thus suggesting a protective role of CD73 in kidney injury. Finally, we identify CD73 as a novel potential diagnostic marker of human podocytopathies, particularly of MCD that has been notorious for the lack of pathological features recognizable by light microscopy and immunohistochemistry.
Placental Transcriptome Adaptations to Maternal Nutrient Restriction in Sheep
Authors: Steinhauser Chelsie B. , Lambo Colleen A. , Askelson Katharine , Burns Gregory W. , Behura Susanta K. , Spencer Thomas E. , Bazer Fuller W. , Satterfield Michael Carey
Published: July 2021

Placental development is modified in response to maternal nutrient restriction (NR), resulting in a spectrum of fetal growth rates. Pregnant sheep carrying singleton fetuses and fed either 100% (n = 8) or 50% (NR; n = 28) of their National Research Council (NRC) recommended intake from days 35–135 of pregnancy were used to elucidate placentome transcriptome alterations at both day 70 and day 135. NR fetuses were further designated into upper (NR NonSGA; n = 7) and lower quartiles (NR SGA; n = 7) based on day 135 fetal weight. At day 70 of pregnancy, there were 22 genes dysregulated between NR SGA and 100% NRC placentomes, 27 genes between NR NonSGA and 100% NRC placentomes, and 22 genes between NR SGA and NR NonSGA placentomes. These genes mediated molecular functions such as MHC class II protein binding, signaling receptor binding, and cytokine activity. Gene set enrichment analysis (GSEA) revealed significant overrepresentation of genes for natural-killer-cell-mediated cytotoxicity in NR SGA compared to 100% NRC placentomes, and alterations in nutrient utilization pathways between NR SGA and NR NonSGA placentomes at day 70. Results identify novel factors associated with impaired function in SGA placentomes and potential for placentomes from NR NonSGA pregnancies to adapt to nutritional hardship.