bluuebunny/crossref_metadata_2025 huggingface dataset:
Украинские источники по истории сношения запорожского казачества с Крымским ханством времен Новой Сечи (1734–1775 гг.) в фондах Центрального государственного архива Украины г. Киева
Authors: Syniak Ivan
Published: September 2024

The publication includes a review of funds and a classification of sources from the history of relations between the Zaporozhian Cossacks of the New Sich era (1734–1775) and the Crimean Khanate, which are stored in the Central State Historical Archive of Ukraine in the city of Kyiv. For each type of document, a description is given, which includes production features and the informative potential of the source. The sources of diplomatic, political, socio-economic communications of the Zaporizhzhya Cossacks with the Crimean Tatars in the specified period have been studied.
Obcokrajowcy w rosyjskiej flocie bałtyckiej w 1722 r. w świetle dokumentów brytyjskich
Authors: Sawicki Mariusz
Published: September 2024

Even before the Great Northern War, Tsar Peter I began building the Russian Baltic Fleet, which played a very important military role in the second phase of that conflict in the aforementioned body of water. Before the conflict, Russia did not have a sufficient number of ships and educated officers, master shipbuilders, or skilled shipyard workers. As a result, foreigners were hired, who were in the vast majority of the Russian fleet at the time. They also received very high honoraria, as mentioned in the reports of British diplomats from Russia, which will be the source basis for this discussion. They did not overlook the training of their cardinals both at home and in other European countries. Ships, on the other hand, which formed the basis of the Baltic fleet, were most often purchased from England and the Netherlands. Based on the surviving documents of British diplomats, it is possible to reconstruct the state of the fleet and the composition of the foreigners serving in it, the number of fees they received, and the number of ships purchased abroad for the Russian Navy.
Influence of Top Management Characteristics on the Innovative Development of the World’s Top Companies in the Pharmaceutical Industry
Authors:   Moscow University of Finance and Law, Tolstov N. A. , Knyazev A. A. ,   SYNERGY University
Published: September 2024

Changes in the pharmaceutical industry lead to the need for detailed consideration of the issues of stimulating innovation, where top management largely determines the company's strategy of innovative development. Thus, it is important to study which characteristics of top management's human capital influence the innovation activity of pharmaceutical companies in creating new products. This article tests a hypothesis that the success of a pharmaceutical company's drug portfolio depends on ideas arising from basic research and large-scale commercialization that recoup high development costs, which in turn are influenced by the personal characteristics of top managers. The study is an econometric analysis of the impact of human capital elements, represented by top management characteristics, on the innovation activity of major pharmaceutical companies, where two models on patents and R&D were tested using panel regression. The models were tested using data from the world’s top 100 pharmaceutical companies from 2010 to 2022. The results made it possible to compile an average portrait of the top manager of the largest pharmaceutical companies. The analysis has shown that professional experience, age, as well as a job-specific degree can have a significant impact on innovation activity. The study contributes to the literature as it makes it possible to predict the innovation strategy of pharmaceutical companies through an average portrait of the top manager. The proposed model will reduce the number of failures of innovative directions, optimize the time period of commercialization of new drug development projects and can be used in other research studies.
Valores de energia metabolizável e coeficientes de metabolizabilidade do extrato etéreo de diferentes tipos de óleo de milho para frangos de corte
Authors: Silva Eduardo Dias da , Valentim Jean Kaique , Oliveira Carlos Henrique de , Dias Kelly Morais Maia , Almeida Bruno Figueiredo de , Vieira Marcílio José , Calderano Arele Arlindo , Albino Luiz Fernando Teixeira
Published: September 2024

Resumo Este estudo teve como objetivo determinar e comparar os valores de energia metabolizável e os coeficientes de metabolizabilidade de três tipos de óleo de milho (bruto, semi-refinado e ácido) em frangos de corte. Foram usados 240 frangos da linhagem Cobb500™, distribuídos aleatoriamente em gaiolas metabólicas com quatro tratamentos, 10 repetições e 6 aves por unidade experimental. As aves foram alimentadas com rações específicas para cada tratamento, e a coleta total de excretas foi realizada dos dias 23 a 27. Os valores de energia bruta (EB), energia metabolizável aparente (EMA) e energia metabolizável aparente corrigida pelo balanço de nitrogênio (EMAn) foram calculados para cada tipo de óleo. Os coeficientes de metabolizabilidade do extrato etéreo (CMEE) também foram determinados. A análise estatística dos resultados foi realizada por meio do teste de Tukey ao nível de 5% de probabilidade. Houve diferença significativa para os valores de EMA e CMEE (P<0,05). O óleo de milho bruto apresentou maiores valores EMA quando comparado ao óleo de milho ácido. O mesmo comportamento foi verificado para o CMEE (P<0,05). Os valores encontrados para os óleos foram: óleo de milho bruto - EB: 9330 kcal/kg, EMA: 8916,84 kcal/kg, EMAn: 8905,60 kcal/kg, CMEE: 97,14%; óleo de milho semi refinado - EB: 9480 kcal/kg, EMA: 8547,99 kcal/kg, EMAn: 8303,46 kcal/kg, CMEE: 96,64%; óleo de milho ácido - EB: 9114 kcal/kg, EMA: 7197,73 kcal/kg, EMAn: 7515,68 kcal/kg, CMEE: 96,17%.
Metanálise sobre características de carcaça e carne de novilhos confinados de diferentes origens genéticas no Brasil
Authors: Pacheco Rangel Fernandes , Teixeira Jullia Sehorek , Pinheiro Bruna Seger da Silva , Souza Murilo Colucci , Dreher Brunna Ferraz , Kerkhoff Gabriel Luis Werner , Donatti Laura Mezzomo , França Brenda Baptista , Teixeira Odilene de Souza , Vaz Ricardo Zambarda
Published: September 2024

Resumo O objetivo do presente estudo foi avaliar as características da carcaça e da carne de novilhos confinados no Brasil de acordo com o grupo genético por meio de uma revisão sistemática e meta-análise. Foi realizada busca eletrônica de artigos nas bases de dados Scielo e Google Acadêmico e os dados foram agrupados de acordo com a predominância genética. Os resultados foram testados quanto à heterogeneidade e submetidos ao teste de normalidade e teste F e as médias comparadas pelo teste de Tukey. Novilhos predominantemente britânicos foram terminados em idade mais jovem, necessitaram de tempos de confinamento mais longos e apresentaram menores pesos de carcaça quente e menores áreas de olho de lombo no abate. Os percentuais de carcaça muscular foram maiores nos novilhos Continentais e Sintéticos em relação aos Britânicos e Zebu, enquanto os percentuais de gordura foram maiores nos Britânicos e Zebu em comparação aos continentais e sintéticos. O marmoreio da carne foi maior nos novilhos britânicos, continentais e mestiços em relação aos novilhos sintéticos e zebuínos. A origem do novilho britânico permite menor idade de abate, embora leve à redução do peso da carcaça quente, enquanto a predominância genética do zebu pode produzir carcaças com alto percentual de gordura.
Orchidaceae in Iguaçu National Park, Paraná, Brazil
Authors: Zubek Hauanna , Curtivo Lizandra Boff , Pessoa Edlley Max , Caxambu Marcelo Galeazzi , Dettke Greta Aline , Temponi Lívia Godinho , Silva Shirley Martins
Published: September 2024

Abstract This study presents a synopsis of the Orchidaceae species in Iguaçu National Park (ParNa Iguaçu), one of the largest Atlantic Forest remnants in the state of Paraná. Orchidaceae is represented in the area by 65 species, distributed in 41 genera, the most representative being Gomesa (7 spp.) and Acianthera (6 spp.). Representatives of three subfamilies are present: Vanilloideae (2 spp.), Orchidoideae (12 spp.) and Epidendroideae (51 spp.) which, as expected, presents the greatest richness (78% of the total). Among the species found, five are considered endemic to Brazil, 23 are endemic to the Atlantic Forest (36%) and one is endemic to Paraná. Thirty-one new records were found for the area. The areas of Mixed Ombrophilous Forest (MOF) had 29 exclusive species, the Semideciduous Seasonal Forest (SSF) had 20, while 16 species occur in both phytophysiognomies. A new occurrence was recorded for MOF. Regarding habit, exclusively epiphytic was the most representative (39 spp.), followed by exclusively terricolous (15 spp.), two vines and one mycoheterotrophic species. Among the families already inventoried in ParNa Iguaçu, Orchidaceae is among the richest and the findings of the present study reinforce the importance of floristic studies for cataloging the local flora.
Perdigão Malheiro e os dilemas do binômio razão e escravidão na história do estado luso-brasileiro
Authors: Ferreira Ricardo Alexandre
Published: September 2024

Resumo Autor oitocentista da obra de cunho jurídico, até então, de maior fôlego sobre a escravidão praticada no Brasil, Agostinho Marques Perdigão Malheiro sempre foi alvo de alguma controvérsia entre os historiadores. Suas teses acabaram enquadradas em esquemas interpretativos que geraram análises, por vezes, depreciativas e outras dotadas de inferências descoladas do universo mais imediato das efetivas fontes de que se serviu o autor. Sua trajetória como político e jurista foi esquadrinhada em busca de retrocessos e ambiguidades e até mesmo algumas das afirmações históricas que fez, a respeito de aspectos legais do cativeiro, foram colocadas sob suspeita. O presente texto, entretanto, desloca a análise dos supostos acertos, erros e compromissos pessoais, intelectuais e políticos do jurista para investigar a hipótese de que seu contributo mais relevante para a construção do Brasil estava assentado na convicção de que a escravidão era um problema fundamental do país, a ser solucionado dentro de parâmetros racionais.
O referencial teórico-metodológico de Jô Benetton nas intervenções de terapia ocupacional com crianças: uma revisão de escopo
Authors: Cestari Leila Maria Quiles , Lopes Kezia Pereira , Bertolozzi Renata Cristina Domingues , Marcolino Taís Quevedo
Published: September 2024

Resumo Introdução O referencial teórico-metodológico brasileiro construído por Jô Benetton, atualmente chamado de Método Terapia Ocupacional Dinâmica, sustenta a prática de terapia ocupacional com diversas populações, inclusive crianças. Há vasta produção de artigos que demandam sistematização para compreender seu escopo. Objetivo Resumir e descrever as produções que utilizam este referencial com crianças e identificar lacunas na literatura. Metodologia Revisão de escopo, com seleção de estudos em bibliotecas e bases digitais (BVS; Portal de Periódicos CAPES, SciELO), sites (Google Acadêmico) e ferramentas de buscas de revistas nacionais da área; busca manual na Revista CETO, e estratégias complementares. Foram incluídos artigos revisados por pares, literatura cinzenta, sem data limite, em português ou inglês. Dados descritivos foram analisados por estatística simples e dados qualitativos receberam análise temática. Resultados Identificaram-se 2.152 estudos, selecionados 106 após leitura de título/resumo, sendo 56 duplicados. Dos 50 estudos lidos na íntegra, 26 foram para análise final. A maioria caracterizou-se por relatos de experiência publicados na Revista CETO, na década de 2000, em português. Os cinco temas identificados explicitam adesão dos estudos ao Paradigma da Terapia Ocupacional, analisando as necessidades das crianças situacionalmente, com intervenções livres e dinâmicas centradas na relação triádica, incluindo pessoas relevantes do cotidiano das crianças, e com uso ainda tímido da análise de atividades pelas crianças. Conclusão Este estudo contribui para dar visibilidade a um corpo de conhecimento teórico-prático construído na realidade brasileira congruente com as principais evidências que visam ampliar o engajamento e a participação de crianças com diferentes problemáticas nas atividades do cotidiano.
The Jo Benetton’s theoretical-methodological framework in occupational therapy with children: a scoping review
Authors: Cestari Leila Maria Quiles , Lopes Kezia Pereira , Bertolozzi Renata Cristina Domingues , Marcolino Taís Quevedo
Published: September 2024

Abstract Introduction The Brazilian theoretical-methodological framework constructed by Jô Benetton, now called the Dynamic Occupational Therapy Method, supports the practice of occupational therapy with different populations, including children. There is a vast production of articles that require systematization to understand their scope. Objective Summarize and describe productions that use this framework with children and identify gaps in the literature. Methodology Scope review, with selection of studies in libraries and digital databases (VHL; CAPES Periodical Portal, SciELO), websites (Google Scholar) and search tools for national journals in the area; manual search in CETO Magazine, and complementary strategies. Peer-reviewed articles, gray literature, without deadline, in Portuguese or English were included. Descriptive data were analyzed using simple statistics and qualitative data received thematic analysis. Results 2,152 studies were identified, 106 selected after reading the title/abstract, 56 of which were duplicates. Of the 50 studies read in full, 26 were for final analysis. The majority were characterized by experience reports published in Revista CETO, in the 2000s, in Portuguese. The five identified themes explain the studies' adherence to the Occupational Therapy Paradigm, analyzing the needs of children situationally, with free and dynamic interventions centered on the triadic relationship, including relevant people from the children's daily lives, and with the still timid use of activity analysis by the children. Conclusion This study contributes to giving visibility to a body of theoretical-practical knowledge built in the Brazilian reality, congruent with the main evidence that aims to increase the engagement and participation of children with different problems in everyday activities.
Mapeamento de ações governamentais sobre a inserção e a permanência da população LGBT no trabalho
Authors: Lima Alexia Costa , Sousa Reinan dos Santos , Duque Andrezza Marques , Braga Iara Falleiros , Souza Marina Batista Chaves Azevedo de
Published: September 2024

Resumo Introdução É importante discutir sobre a relação entre a população LGBT, o trabalho e as responsabilidades governamentais acerca das inserções e permanências nesta atividade, uma vez que na sociedade capitalista o trabalho é o elo fundamental entre as pessoas, seus projetos de vida e sua participação social. Objetivo Mapear ações e/ou práticas em endereços eletrônicos controlados pelo Estado brasileiro que tinham como objetivo principal a inserção/permanência de pessoas LGBT no trabalho. Métodos Trata-se de um estudo exploratório, qualitativo e documental. Resultados Retornaram 90 ações, a maioria concentrada no ano de 2022 e na região Nordeste do Brasil. As ações estavam relacionadas ao trabalho informal e não foi possível afirmar que estas garantem a inserção/permanência no trabalho. Considera-se que os governos devem realizar parcerias com empresas públicas, privadas e com o terceiro setor, responsabilizando-os, normatizando e garantindo a inserção/permanência. Conclusão É preciso uma reparação histórica, diminuição da exclusão, do preconceito e das violências contra a comunidade LGBT. Desta forma, aponta-se que ainda estão colocados muitos e complexos desafios para a participação social desta população, considerando a inclusão por meio do trabalho.
Mapping of government actions on the insertion and permanence of the LGBT population at work
Authors: Lima Alexia Costa , Sousa Reinan dos Santos , Duque Andrezza Marques , Braga Iara Falleiros , Souza Marina Batista Chaves Azevedo de
Published: September 2024

Abstract Introduction It is important to discuss the relationship between the LGBT population, work and government responsibilities regarding insertions and permanence in this activity, since in capitalist society work is the fundamental link between people, their life projects and their participation Social. Objective To map actions and/or practices on electronic addresses controlled by the Brazilian State that had as their main objective the insertion/permanence of LGBT people at work. Methods This is an exploratory, qualitative and documentary study. Results 90 actions returned, the majority concentrated in the year 2022 and in the Northeast region of Brazil. The actions were related to informal work, and it was not possible to state that they guarantee insertion/permanence in work. It is considered that governments must form partnerships with public and private companies and the third sector, holding them accountable, standardizing and guaranteeing insertion/permanence. Conclusion Historical reparation is needed, reducing exclusion, prejudice and violence against the LGBT community. In this way, it is pointed out that there are still many complex challenges for the social participation of this population, considering inclusion through work.
Quality of life, stress, coping and burden of caregivers of older people with Alzheimer's
Authors: Lin Chia Chen , Marques Izabela Vitória Pereira , Silva Grazieli Covre da , Silva Eduardo Quadros da , Colombari Agnes Vitório , Nascimento Junior José Roberto Andrade do , Oliveira Daniel Vicentini de
Published: September 2024

Abstract Introduction Caring for older people with Alzheimer's disease can generate a state of prolonged stress, especially when the overload is intense, which impacts the caregiver's quality of life. Objective To compare the quality of life, perception of stress, and coping strategies depending on the level of overload of caregivers of older people with Alzheimer's. Methods Quantitative and cross-sectional study carried out with 126 caregivers of older people with Alzheimer's. The World Health Organization Quality of Life Bref (WHOQOL-Bref), Perceived Stress Scale, Zarit Overload Inventory, and the Problem Coping Scale were used. Data analysis was performed using the Kolmogorov-Smirnov test, boot-strapping procedures, and one-way ANOVA, followed by Tukey's posthoc. A significance of p < 0.05 was adopted. Results Caregivers with intense burden had worse quality of life (p < 0.001). Caregivers without overload had less stress (p < 0.001) and used a problem-focused coping strategy (p < 0.001). Conclusion The level of overload is an intervening factor in the quality of life, stress symptoms, and coping strategies of caregivers of older people with Alzheimer's Disease.
A educação no retorno às aulas pós-pandemia: a visão de professores em exercício de direção sindical
Authors: Souza Katia Reis de , Santos Gideon Borges dos , Rodrigues Andréa Maria dos Santos
Published: September 2024

O objetivo deste artigo consiste em problematizar mudanças ocorridas nos processos de trabalho docente com foco no retorno presencial às aulas, pós-pandemia e suas implicações para a saúde do professor. Trata-se de uma pesquisa social de caráter qualitativo e de natureza pedagógica, com ênfase em estratégias participativas de produção de conhecimento. Utilizou-se a metodologia da Comunidade Ampliada de Pesquisa adaptada para o ambiente virtual. Para coleta das informações, realizaram-se duas oficinas virtuais, cujas discussões foram analisadas conforme a técnica da análise de conteúdo temática, obtendo-se as seguintes categorias: “mudanças no trabalho em escolas”; “tempo tecnológico de trabalho e horas extraclasse não remuneradas”; “defasagens e cansaço pós-pandêmico”; “saúde nos rescaldos da pandemia”; e “o papel pedagógico da vigilância sindical pela saúde”. Por fim, observou-se a importância do papel pedagógico da vigilância sindical pela saúde em contexto de adversidades social e política.
Participação social: teoria e prática na formação graduada em Terapia Ocupacional
Authors: Silva Ana Cristina Cardoso da , Oliver Fátima Correa
Published: September 2024

A participação social está nos debates sobre as transformações e a diversidade teórico-metodológica na Terapia Ocupacional. Com esse contexto, buscou-se identificar se a participação social, em seu âmbito teórico-prático, é abordada no processo de formação graduada em Terapia Ocupacional e como tem sido trabalhada com os alunos. De maneira colaborativa, terapeutas ocupacionais docentes de instituições de ensino superior públicas e privadas responderam a um questionário. A maioria incluiu o conceito nas discussões teóricas e na construção de práticas e pesquisas dentro e fora da sala de aula. Há relação entre os diferentes campos de atuação; ensino; pesquisa e extensão; modos e metodologias de trabalho; população atendida; seus contextos de vida, demandas e necessidades; e os pontos de vista sobre a participação social. Isso exemplifica a flexibilização dos currículos e a possibilidade de traçar diferentes caminhos para formação graduada.
REMOTE SENSING IN THE WAVE COMPLEX WITH CRITICALLY SMALL SIZES: REMOTE SENSING OF AN INSOLUBLE SURFACTANT'S FILMS
Authors: Uzlenkov Alexandr V. , Lyubitsky A. A.
Published: September 2024

The results of modeling and remote sensing of surfactant surface contamination in a critically small-sized
wave basin are described. The method of creating and maintaining an oil film is described. The peculiarities
of the dynamics of surface concentration over time and the relationship between the primary and working concentrations of surfactants with each other and with the parameters of the basin were evaluated. A simulation of the film-formation process was performed, which made it possible to assess
the properties of the film in the stabilization mode and the duration of maintaining this mode. The properties of wave damping by generated films were estimated by quasi-contact optical methods and remote sensing with a multi-frequency scatterometer. The obtained hydrodynamic and radar results are compared with the corresponding theoretical models and experimental data known in the literature, including those obtained in situ. Detailed energy and frequency parameters of spectra during multi-frequency sounding are given. Anomalous situations during the probing of films in a small-sized pool are considered. The possibility and limits of correct interpretation of the obtained results for in situ conditions are discussed. A range of tasks related to hydrodynamics and remote sensing of water surface pollution, in the solution of which it is possible to use a small-sized wave complex, is outlined.
Animales silvestres en los circos y caza deportiva: avanzando en la protección jurídica de los animales
Authors: Monsalve Mantilla Milton Duban , Monsalve Mantilla Yesenia Andrea ,   Ministerio de Educación Nacional
Published: September 2024

Propósito: con el presente escrito, se pretende describir la prohibición legal de tenencia y uso de animales silvestres (nativos o exóticos) en los circos; entender la prohibición de la caza de animales con fines deportivos o recreativos en Colombia; y, por último, señalar unas breves conclusiones que dan cuenta de dos ejemplos claros en los que se premia el interés superior en la protección jurídica de los animales en el ordenamiento jurídico colombiano. Metodología: a través de un análisis documental descriptivo, se indaga por la tenencia y utilización de animales silvestres en los circos, y por la caza deportiva y su incidencia en la protección de animales silvestres en Colombia, con la revisión de la normativa nacional y la jurisprudencia, y acudiendo al análisis de fuentes para hacer un contraste entre las decisiones de carácter legislativo y las judiciales. Conclusiones: la restricción de la tenencia y el uso de animales salvajes, tanto exóticos como autóctonos, en los espectáculos circenses, junto con la prohibición de la caza recreativa, son ejemplos destacados en los que se avanza en la protección jurídica de los animales, gracias a la labor del legislador y gracias a la decisión jurisdiccional por parte de la Corte Constitucional de Colombia.
Avaliação multicritério da ciclabilidade da rede viária em Montes Claros/MG
Authors: Lopes Rafael Aparecido Pereira , Santos Neto Narciso Ferreira dos
Published: September 2024

This study investigated the cycling infrastructure and cyclists' perceptions of sustainable urban mobility in Montes Claros, Minas Gerais, Brazil, based on bicycle use. The methodology involved an analysis of the road environment for cyclists and the application of questionnaires to experts and cyclists, using a multi-criteria approach. The results revealed limitations in the infrastructure, such as the lack of segregated bike lanes. Additionally, cyclists expressed concerns about safety, such as disrespect from drivers and insufficient lighting on roads. These findings highlight the need for investments in cycling infrastructure and public policies focused on safety and sustainable mobility. This study contributes to the knowledge of cyclability in Montes Claros by developing a procedure for cyclability analysis that can be used in other locations. Furthermore, it provides valuable information for urban planning and the promotion of bicycle use as a sustainable mode of transportation, with the potential to improve urban mobility and quality of life for the population.
POLA RELASI PENCAMBUK-PENANGKIS DALAM TARIAN CACI DAN SUMBANGANNYA PADA ELEGANSI DIALOG DI INDONESIA
Authors:   Sekolah Tinggi Filsafat Teologi Widya Sasana, Sailtus Fransiskus , Pandor Pius ,   Sekolah Tinggi Filsafat Driyarkara Jakarta
Published: September 2024

This paper aims to explore the intersubjective relationship between the whipper (paki) and the parrier (ta’ang) in caci, a traditional dance from Manggarai, East Nusa Tenggara Province. For that purpose, this study applied the phenomenological method. In this method, caci is described based on what actually transpires during the performance when the researchers made direct observations. As a native Manggarai, the researcher has watched the dance for many years. Data from the phenomenological study were analyzed using Armada Riyanto’s philosophical concept of intersubjective relationality. This study found that the relationship between the whipper and the parrier in caci is not a subject-object but intersubjective one. The intersubjectivity of the whipper-parrier relationship is demonstrated by several facts. First, there is subjective identity of the whipper and parrier in the form of their names. Second, there is affirmation of identity and its confirmation during the dance. Third, the act of whipping and parrying does not involve a large group of people, but only the whipper and parrier as individual actors. Fourth, the whipper and parrier are aware of the other party’s presence and role. Fifth, the whipper is aware of the presence and role of the parrier and vice versa. Sixth, the whipper and parrier are encountering each other with mutual respect. The intersubjective element of the whipper-parrier relationship is highly relevant to the promotion of elegant intercultural dialogues in Indonesia.
Combined treatment of wounded with traumatic aneurysm of posterior communicating artery complicated by intraventricular hemorrhage
Authors: Gizatullin Sh. Kh. , Vinogradov E. V. , Davydov D. V. , Kolobaeva E. G. , Isengaliev I. N. , Onnitsev I. E. , Antokhov V. P.
Published: September 2024

Cerebral blood vessel trauma (CBVT) is a serious condition of craniocerebral injury. According to literature data, different varieties of CBVT in penetrating gunshot craniocerebral injuries are found in 30–45 % of cases. Traumatic pseudoaneurysms are the most common finding in late evaluation and can lead to life-threatening episodes of intracranial hemorrhage.In addition, CBVT includestraumatic occlusion, dissection of vessels, rupture of cerebral arteries, formation of arteriovenous fistulas (carotid-cavernous anastomoses), venous stasis, etc. Injured persons with traumatic dissection and injury of vertebrobasilar pool have the highest risks of lethal outcome. There are no largerandomised trials and national recommendations for the treatment of CBVT, individual observations and small series of clinical cases have been published. In this connection, there is a need for a detailed analysis of all clinical cases, the development of tactics for early diagnosis and an algorithm for the treatment of wounded with CBVT.The article presents a review of the literature data that characterizes the current understanding of CBVT, and a clinical case of traumatic occlusion of the middle cerebral artery and pseudoaneurysm of the posterior communicating artery in a wounded man with a gunshot penetrating cranioorbital wound, who was treated at the neurosurgical center of the N.N. Burdenko Main Military Clinical Hospital.In the early period after the injury, the patient underwent endovasal occlusion of a traumatic aneurysm of the posterior connective artery by microspirals followed by local thrombolysis of intraventricular hematomas through a ventricular catheter. The catamnesis was 150 days, the score on the modified Rankin scale was 3, the Glasgow outcome scale extended was 5.
Surgical treatment of spinal neurenteric cysts
Authors: Evzikov G. Yu. , Abdrafiev R. I. , Argylova V. N.
Published: September 2024

Background. Spinal neurenteric cysts are very rare benign space-occupying lesions in the vertebral canal emerging due to anomalies of neural tube development during prenatal development of the fetus. Clinically, neurenteric cysts can manifest both in childhood and adulthood.Aim. To evaluate the results of surgical treatment of adult patients with spinal neurenteric cysts who were operated on at the Neurosurgery Division of the Clinic of Nervous System Diseases of the I.M. Sechenov First Moscow State Medical University.Materials and methods. The study group included 3 patients (2 women and 1 man) with mean age of 33 years. The main diagnosis method was magnetic resonance imaging. In all cases, radical cyst resection was performed with subsequent histological examination of cyst walls.Results. In all observations, cyst walls had local areas of increased density and thickness: a distinctive solid component accumulating the contrast agent in magnetic resonance images. This type of structure is considered extremely rare per descriptions presented in literature, but in our case series it was detected in all patients. Cyst resection led to pain syndrome regression and almost full regression of clinical manifestations of spinal cord compression which justifies active surgical tactics in this pathology.Conclusion. Neurenteric cyst of the vertebral canal can cause spinal cord compression. The main diagnostic method of this pathology is magnetic resonance imaging, however magnetic resonance semiotics of these cyst has not been standardized. The presence of constant pain syndrome without marked clinical signs of compression myelopathy is sufficient reason for cyst resection surgery. Cyst resection allowsto achieve regression of pain syndrome and neurological abnormalities caused by spinal cord compression.
Traumatic lateral spondyloptosis and lateraloptosis with partial improvement through posterior surgical approach: a review based on a case report
Authors: Vasquez-Paredes G. , Zavaleta-Corvera C. , Riveros-Hernandez O. , Caballero-Alvarado J. , Muente-Alva L. S.
Published: September 2024

Introduction. Spondyloptosis or grade V of spondylolisthesis, spinal injury that involve 100 % mobilization of the vertebral body, is rare to find. Lateraloptosis, displacement of vertebral bodies, is even more rare a catastrophic.The aim of this study to introduce readers to this rare form of traumatic lumbar spine injury as well as to review current available therapeutic approaches.Case report. A 22-year-old male was admitted to the emergency room due to a fall from a moving truck. Physical examination revealed neurological deficit in the lower extremities, with muscle strength 0/5, and an ASIA B classification. Computed tomography study showed a complete lateroloptosis at the L3 –L4 level. The patient is admitted to the operating room for surgical treatment through a posterior approach. Successful arthrodesis and spinal alignment are achieved. Immediate postoperative period, showed no complications and the patient’s neurological function in the lower extremities was classified as ASIA C. In the posterior follow-up, the patient maintains the motor neurological function and recover the autonomic control of bladder function. With mild disability according to the Barthel Index of 90 points.Discussion. of the traumatic spinal injuries, spondyloptosis is the most infrequent and occurs secondary to high-energy mechanisms. It presents an incidence of complete neurological deficit in 80 % of patients. The objectives in surgical treatment are decompression of neurovascular structures, reduction of fracture dislocation to improve alignment in the sagittal and coronal plane, and instrumentation that allows stability. The posterior surgical approach offers advantages over the anterior approach. In the posterior approach, the facet joints can be manipulated more safely, decompress the nerve roots and the dural sac more easily, as well as less operating time and greater care of vascular structures such as the iliac vessels.Conclusion. Complex traumatic spinal injuries are associated with irreversible neurological damage. Achieving spinal stability and alignment allows optimizing physical therapy and rehabilitation for greater recovery. Severe spinal injuries, especially lateroptosis, are difficult to treat by surgical approach, however, the main objective is vertebral stabilization to allow physical therapy and early rehabilitation.
Electric stimulation using stereoelectroencephalography electrodes
Authors: Russkin V. O. , Kuznetsova A. A. , Solovyev V. B. , Levov A. V. , Berdinov F. B. , Livshits M. I. , Sandrikov V. A.
Published: September 2024

Electrical stimulation (ES) using stereoelectroencephalography is an essential component in the workup of surgical epilepsy. ES helps to solve two major problems in epilepsy surgery – total resection of the epileptogenic lesion while minimising the postoperative neurological deficit. ES allows to induce habitual epileptic seizures to define the neurophysiological characteristics and boundaries of the epileptogenic zone and to map eloquent areas to reduce the area of resection with prediction of post-operative neurological deficit. The results of studies using ES make a huge contribution not only to practical medicine, but also to fundamental science, allowing us to study the functions of individual parts of the brain and to understand the elements of the pathogenesis of various diseases of the nervous system.
Third ventricle teratoma with malignant transformation
Authors: Akchurina Yu. R. , Gorozhanin V. A. , Shatokhin T. A. , Lukyanchikov V. A.
Published: September 2024

Intracranial germ cell tumors(GCTs) are rare and heterogeneous group of primary brain tumors, mainly affecting pediatric population and young adults. The current understanding of the etiology of intracranial GCTs and their optimal management strategies remain controversial. Treatment plans differ depending on the subtype GCT and may vary among physicians and institutions. Central nervous system non-germinomatous germ cell tumor (NGGCT) usually requires surgical resection with histological verification, chemotherapy, and radiation. The extent of surgical resection is an important prognostic factor alongside the etiology and genetics of NGGCT. This article presents a rare clinical case of a rapidly growing teratoma located in the posterior part of third ventricle of a 17-year-old male presenting with symptoms of intracranial hypertension. Surgical total resection was preceded by endoscopic third ventriculostomy. Immunohistochemistry revealed the presence of embryonal carcinoma and immature teratoma cells turning the tumor into mixed type NGGCT with unfavorable prognosis. Despite the complete resection of the tumor and the timely initiation of adjuvant therapy, a rapid progression of the disease with subsequent unfavorable outcome was observed 3.6 months after the surgical treatment.
Difficulties of reperfusion therapy of cerebral infarction in a patient with erythrocytosis
Authors: Prozorov S. A.
Published: September 2024

A brain infarction can occur as a result of rare diseases of the blood system. The clinical observation of reperfusion therapy in a patient with the Chuvash type of hereditary familial erythrocytosis is given. Although the patient took acetylsalicylic acid (500 mg per day), thrombosis of the M1 segment of the middle cerebral artery occurred. Despite the introduction of alteplase, a recombinant tissue plasminogen activator, thromboaspiration and thromboextraction to the patient, success was short-lived and retrombosis occurred. It is necessary to further study the problem of treating patients with cerebral infarction associated with hematological disease.
Role of endothelial dysfunction in reducing ovarian reserve in women with chronic salpingophoritis
Authors: Burova Natalia A. , Klimentova Tamara S. , Iarygin Oleg A. , Burdenko Larisa G.
Published: September 2024

Chronic salpingophoritis is a critical inflammatory disease of the pelvic organs and is a risk factor of diminished ovarian reserve. Notably, chronic salpingophoritis is accompanied by decreased blood supply in the uterus. Circulation in the peripheral bloodstream of pathological inflammatory factors and immune complexes in the blood contributes to the development of oxidant stress, which damages the endothelium vessels and leads to impairment of its functions. Against the background of long-term pathological reactions in the inflammation center forms a vicious circle, wherein endothelial dysfunction plays a crucial role in the development of sclerotic processes in the ovarian tissues and endocrine function of the organ. These persistent morphofunctional disorders contribute to the delay of follicle maturation, which leads to decreased ovarian reserve. The result of the study reveals that, in women, during the peak of reproductive function, having chronic salpingophoritis and reduced ovarian reserve, blood flow in the ovarian arteries deteriorates. Pronounced changes in the dopplerometric blood flow parameters in the ovarian arteries are caused by damage to the vascular wall such as distortion of its tone and disorders in the production of vasoconstrictors and vasodilators (NO and ET-1). This is exacerbated by blood vessel endothelial thrombogenicity and results in long-term endothelial dysfunction, which contributes to impaired hormonal function of the ovaries. Notably, a persistent disorder of vasodimotor and thrombogenic endothelial function leads to a decrease in recruitment of follicles in the ovaries and reduction in ovarian reserve in the selected patient population.
New therapeutic approaches for improving the outcomes of assisted reproductive technologies
Authors: Levakov Sergey A. , Gromova Tatyana A. , Rudyakova Elizaveta A.
Published: September 2024

Infertility is a global health problem that affects up to 17.5% of the world’s population. The use of assisted reproductive technologies makes it possible to solve this problem; however, it is not adequately efficient in all observed cases. Implantation failure remains a serious and multifaceted problem faced by clinicians in reproductive technology, despite the significant advances that have been made in this area. This review highlights promising studies on medical and invasive intervention methods and their possible combinations, which potentially improve the clinical treatment of implantation failures. Nevertheless, further study is required to assess the effectiveness and safety of each therapeutic approach, which can introduce new prospects in the treatment of infertility and increase the chances of successful implantation and pregnancy.
Risk factors for postpartum depression
Authors: Korolyova Daria V. , Yakunina Sofia A. , Shemyakin Vladislav V. , Svidinskaya Evgeniya A. , Sosnova Elena A.
Published: September 2024

Postpartum depression has become an increasingly urgent problem of modern medicine and psychology. This condition is a mental disorder that causes emotional, behavioral, and physical changes associated with the postpartum period. Despite the presence of a wide range of signs, the diagnosis of postpartum depression remains challenging for specialists. A woman experiencing this type of depression may find it difficult to realize her condition on her own and seek help. However, even if properly diagnosed, the fact of having postpartum depression can be a negative experience for a woman. Young mothers often feel fear or shame in front of family members and the society and hide their diagnosis. This creates additional barriers to getting the necessary help and support.
This review aimed to identify and analyze risk factors of depressive disorders in women in the postpartum period and investigate some manifestations of postpartum depression.
The scientific databases CyberLeninkа, eLibrary, and PubMed were used. The articles were searched for the following keywords: “postpartum period,” “depressive disorder,” “postpartum depression,” “postpartum depression and risk factors,” and “development of depressive disorders in the postpartum period.” The study included articles published over the past 5 years. After sampling by annotations and keywords, 53 articles were analyzed: 6 Russian and 47 English speakers. The risk factors described in modern domestic and foreign literature were analyzed and were classified as unmodified and modifiable, which was further characterized as modifiable by the mother and/or her family and modifiable only by healthcare.
Clinical and morphological specifics, pathogenetic ways of skin manifestations in SARS-CoV-2 infection
Authors: Severgina Lyubov O. , Olisova Olga Yu. , Martynenko Дарья М. , Demura Tatiana A.
Published: September 2024

To date, the most studied clinical and morphological changes characteristic of SARS-CoV-2 virus are its pulmonary manifestations and cardiovascular involvement. However, the evaluation of COVID-associated skin changes and the analysis of their mechanisms are also important for us, because the skin manifestations of the infection can change the patient's appearance for the worse, i.e. affect the aesthetic sphere and significantly reduce the quality of life. The study of not only skin manifestations of COVID-19, but also their morphological substrate and pathogenetic basis allows us to apply the most effective methods of treatment and provide adequate management of patients even in the post-coital status.
According to the information collected to date, the most frequently reported skin manifestations of SARS-CoV-2 are pseudo-frostbite, maculopapular and vesicular lesions, urticaria, lividoid and necrotic lesions, hemorrhagic purpura (vasculitis), and conditions from the group of other unclassified skin lesions. Despite the variety of clinical variants of SARS-CoV-2-associated skin changes, morphological stigmas are often stencil-like: these are areas of lymphohistiocytic infiltration of perivascular localization, the presence of fibrinoid necrosis foci in the vessel walls, the formation of occlusive thrombi, erythrocyte extravasation. Mechanisms of damage to epidermis and dermis within COVID-19 infection may be due to the influence of complement components, activation of cytotoxic lymphocytes and NK-cells, excessive synthesis of proinflammatory cytokines, in particular, interleukin 6, as well as interferons, hyperergic reactions. In addition to routine morphological, immunohistochemical examination of skin biopsy specimens from patients with different forms of skin manifestations of SARS-CoV-2 infection is an important tool in the diagnostic confirmation of COVID-associated dermatologic pathology, especially in patients with a suspected history of this disease or with problematic laboratory results.
The priority of bacteria Staphylococcus spp. in the etiology of purulent septic infections through the prism of new diagnostic capabilities: A literature review
Authors: Borisov Alexander M. , Golubkova Alla A. , Ruzhentsova Tatiana A.
Published: September 2024

Representatives of the genus Staphylococcus spp. occupy a leading place in the etiology of infections caused by opportunistic bacteria. Staphylococcus spp., being symbionts of humans and/or animals, are constantly located on the surface of the skin and mucous membranes, which are their natural habitats.
The importance of bacteria of the genus Staphylococcus spp. It is determined by their significant distribution in the population, as well as among patients and medical personnel, due to their transient and resident carrier, as well as their high adaptive potential, due to their ability to form biofilms and produce enzymes that provide them with protection from antimicrobial drugs.
Modern molecular genetic methods for identifying Staphylococcus spp. and assessing their epidemic potential allow us to rethink their importance in the etiology of nosocomial purulent septic infections in a new way. It is no coincidence that they entered the group of ESCAPE pathogens with a high level of priority.
The ability of staphylococci to form biofilms ensures their survival in various hospital/environmental facilities, which in the conditions of a medical organization become additional, or so-called “inanimate” sources of infection.
In recent years, despite the increasing role of coagulase-negative staphylococci in the etiology of purulent septic infections, Staphylococcus aureus remains the most significant causative agent of purulent septic infections.
Changes in the liver of Djungarian hamsters under conditions of a three-month supply of water-soluble silicon of various concentrations
Authors: Grigoreva Evgeniia A. , Gordova Valentina S. , Sergeeva Valentina E. , Mikheikin Roman D. , Dedikina Valeriia S. , Braun Darya A.
Published: September 2024

BACKGROUND: Silicon enters the human body through drinking water, air and food. Silicon nanoparticles used in the cosmetic, pharmaceutical and food industries are known to have biological activity. Taking into account the widespread prevalence of silicon compounds, the issue of the safety of its use is becoming more urgent.
AIM: To study the effect of water-soluble silicon on the morphological structure of the liver of Djungarian hamsters for three months.
MATERIALS AND METHODS: The experiment was carried out on Djungarian hamsters kept in normal vivarium conditions under natural light. The animals were divided into three groups: control, which received bottled drinking water; the first experimental group, which received the same water, but with the addition of sodium metasilicate nine-hydrate at a concentration of 10 mg/l in terms of silicon; the second experimental group, which also received the same water, but with the concentration of sodium metasilicate nine-hydrate doubled (up to 20 mg/l). After three months, the animals were removed from the experiment. Sections were processed by general histological (hematoxylin and eosin, Van Gieson method, toluidine blue), histochemical (monoamine oxidase-positive cells) methods.
RESULTS: In the liver of hamsters from the experimental groups, changes in the micromorphological structure were revealed, such as an increase in the nuclear area, nuclear-cytoplasmic ratio of hepatocytes, and the diameter of sinusoidal capillaries. Moreover, more pronounced changes were observed in the liver of hamsters of the second experimental group, such as polymorphic cell infiltration of the portal tracts, an increase in the number of eosinophils, deformation of hepatocyte nuclei and the appearance of apoptotic bodies. A decrease in the area of mast cells and an increase in their number, as well as the number of monoamine oxidase-positive cells in the liver of hamsters of both experimental groups were recorded.
CONCLUSIONS: An increase in the concentration of silicon supplied with drinking water in both cases is reflected in the micromorphological structure of the liver of hamsters. Moreover these changes are more pronounced in the liver of hamsters of the second experimental group.