bluuebunny/crossref_metadata_2025 huggingface dataset:
What distinguishes patients with mass social media-induced illness presenting with Tourette-like behavior from those with Tourette syndrome? Results of a prospective cohort study
Authors: Fremer Carolin , Szejko Natalia , Pisarenko Anna , Haas Martina , Laudenbach Luise , Wegener Claudia , Müller-Vahl Kirsten R.
Published: May 2023

Since 2019, a global increase in patients presenting with functional Tourette-like behaviors (FTB) has been observed. This has been related to the exposure of tic-related content in social media, although other factors seem to further fuel this phenomenon. Recently, we, therefore, proposed the term mass social media-induced illness (MSMI) as, in our opinion, this phenomenon constitutes a new type of mass sociogenic illness (MSI) that is in contrast to all recent outbreaks spread solely via social media. In accordance with this hypothesis, we were able to identify the host of the German YouTube channel "Gewitter im Kopf" (“Thunderstorm in the brain”) as the initial virtual index case. The purpose of this paper is to present clinical characteristics of a sample of 32 patients diagnosed with MSMI-FTB compared to a large sample of patients with Tourette syndrome (TS) and other chronic tic disorders (CTD) (n = 1032) from the same center in Germany indicating clinical factors helpful to distinguish between tics in TS/CTD and MSMI-FTB. Our main findings were: in patients with MSMI-FTB compared to those with TS/CTD we found (i) a significantly higher age at onset, (ii) a significantly higher rate of females, (iii) a significantly higher rate of obscene and socially inappropriate symptoms, (iv) a significantly lower rate of comorbid ADHD, and (v) a significantly lower rate of OCD/OCB. In contrast, rates of comorbid anxiety and depression as well as reported frequencies of premonitory urges/sensations and suppressibility of symptoms did not differ between groups.
Truncated nonsmooth Newton multigrid for phase-field brittle-fracture problems, with analysis
Authors: Gräser Carsten , Kienle Daniel , Sander Oliver
Published: May 2023

We propose the truncated nonsmooth Newton multigrid method (TNNMG) as a solver for the spatial problems of the small-strain brittle-fracture phase-field equations. TNNMG is a nonsmooth multigrid method that can solve biconvex, block-separably nonsmooth minimization problems with linear time complexity. It exploits the variational structure inherent in the problem, and handles the pointwise irreversibility constraint on the damage variable directly, without regularization or the introduction of a local history field. In the paper we introduce the method and show how it can be applied to several established models of phase-field brittle fracture. We then prove convergence of the solver to a solution of the nonsmooth Euler–Lagrange equations of the spatial problem for any load and initial iterate. On the way, we show several crucial convexity and regularity properties of the models considered here. Numerical comparisons to an operator-splitting algorithm show a considerable speed increase, without loss of robustness.
Fatigue in fluctuating Parkinson’s disease patients: possible impact of safinamide
Authors: Pauletti Caterina , Locuratolo Nicoletta , Mannarelli Daniela , Maffucci Andrea , Petritis Alessia , Menini Elisa , Fattapposta Francesco
Published: May 2023

Fatigue is a common non-motor symptom in Parkinson’s disease (PD). Among other pathophysiological mechanisms, neuroinflammation, a pathological PD hallmark associated with changes in glutamatergic transmission in basal ganglia, has been proposed as a crucial factor closely related to fatigue. To test the hypothesis that safinamide could represent an effective treatment of fatigue in PD patients, given its dual mechanism of action (it selectively and reversibly inhibits MAOB and modulates glutamate release), we administered the validated versions of fatigue severity scale (FSS) and Parkinson fatigue scale-16 (PFS-16) to 39 fluctuating PD patients with fatigue before and after a 24-week treatment period with safinamide as add-on therapy. An assessment of secondary variables such as depression, quality of life (QoL), and motor and non-motor symptoms (NMS) was conducted. After 24 weeks of treatment with safinamide, both FSS (p < 0.001) and PF-S16 (p = 0.02) scores were significantly lower than at baseline. Moreover, 46.2% and 41% of patients scored below the cut-off for the presence of fatigue according to FSS and PFS-16, respectively (responders). At follow-up, a significant difference emerged between responders and non-responders in mood, QoL, and NMS. Fatigue improved in fluctuating PD, and more than 40% of patients were “fatigue-free” after a 6 month treatment with safinamide. Patients without fatigue at follow-up displayed significantly better scores in QoL domains, such as mobility or activities of daily living, although disease severity remained stable, supporting the hypothesis that fatigue could considerably affect QoL. Drugs that interact with multiple neurotransmission systems, such as safinamide, could be useful in reducing this symptom.
Isolation and genetic characterization of a mammalian orthoreovirus from Vespertilio sinensis in Japan
Authors: Ichikawa Ayano , Katayama Misa , Lai Hayden , Wataru Sekine , Takenaka-Uema Akiko , Horimoto Taisuke , Murakami Shin
Published: May 2023

Throughout East Asia, Europe, and North America, mammalian orthoreovirus (MRV), for which bats have been proposed to be natural reservoirs, has been detected in a variety of domestic and wild mammals, as well as in humans. Here, we isolated a novel MRV strain (designated as Kj22-33) from a fecal sample from Vespertilio sinensis bats in Japan. Strain Kj22-33 has a 10-segmented genome with a total length of 23,580 base pairs. Phylogenetic analysis indicated that Kj22-33 is a serotype 2 strain, the segmented genome of which has undergone reassortment with that of other MRV strains.
Effect of nintedanib in patients with progressive pulmonary fibrosis associated with rheumatoid arthritis: data from the INBUILD trial
Authors: Matteson Eric L. , Aringer Martin , Burmester Gerd R. , Mueller Heiko , Moros Lizette , Kolb Martin
Published: May 2023

Objectives

Some patients with rheumatoid arthritis develop interstitial lung disease (RA-ILD) that develops into progressive pulmonary fibrosis. We assessed the efficacy and safety of nintedanib versus placebo in patients with progressive RA-ILD in the INBUILD trial.

Methods

The INBUILD trial enrolled patients with fibrosing ILD (reticular abnormality with traction bronchiectasis, with or without honeycombing) on high-resolution computed tomography of >10% extent. Patients had shown progression of pulmonary fibrosis within the prior 24 months, despite management in clinical practice. Subjects were randomised to receive nintedanib or placebo.

Results

In the subgroup of 89 patients with RA-ILD, the rate of decline in FVC over 52 weeks was −82.6 mL/year in the nintedanib group versus −199.3 mL/year in the placebo group (difference 116.7 mL/year [95% CI 7.4, 226.1]; nominal p = 0.037). The most frequent adverse event was diarrhoea, which was reported in 61.9% and 27.7% of patients in the nintedanib and placebo groups, respectively, over the whole trial (median exposure: 17.4 months). Adverse events led to permanent discontinuation of trial drug in 23.8% and 17.0% of subjects in the nintedanib and placebo groups, respectively.

Conclusions

In the INBUILD trial, nintedanib slowed the decline in FVC in patients with progressive fibrosing RA-ILD, with adverse events that were largely manageable. The efficacy and safety of nintedanib in these patients were consistent with the overall trial population. A graphical abstract is available at: https://www.globalmedcomms.com/respiratory/INBUILD_RA-ILD.

Key Points• In patients with rheumatoid arthritis and progressive pulmonary fibrosis, nintedanib reduced the rate of decline in forced vital capacity (mL/year) over 52 weeks by 59% compared with placebo.• The adverse event profile of nintedanib was consistent with that previously observed in patients with pulmonary fibrosis, characterised mainly by diarrhoea.• The effect of nintedanib on slowing decline in forced vital capacity, and its safety profile, appeared to be consistent between patients who were taking DMARDs and/or glucocorticoids at baseline and the overall population of patients with rheumatoid arthritis and progressive pulmonary fibrosis.
Relaxation measurements of an MRI system phantom at low magnetic field strengths
Authors: Martin Michele N. , Jordanova Kalina V. , Kos Anthony B. , Russek Stephen E. , Keenan Kathryn E. , Stupic Karl F.
Published: May 2023

Objective

Temperature controlled T1 and T2 relaxation times are measured on NiCl2 and MnCl2 solutions from the ISMRM/NIST system phantom at low magnetic field strengths of 6.5 mT, 64 mT and 550 mT.

Materials and methods

The T1 and T2 were measured of five samples with increasing concentrations of NiCl2 and five samples with increasing concentrations of MnCl2. All samples were scanned at 6.5 mT, 64 mT and 550 mT, at sample temperatures ranging from 10 °C to 37 °C.

Results

The NiCl2 solutions showed little change in T1 and T2 with magnetic field strength, and both relaxation times decreased with increasing temperature. The MnCl2 solutions showed an increase in T1 and a decrease in T2 with increasing magnetic field strength, and both T1 and T2 increased with increasing temperature.

Discussion

The low field relaxation rates of the NiCl2 and MnCl2 arrays in the ISMRM/NIST system phantom are investigated and compared to results from clinical field strengths of 1.5 T and 3.0 T. The measurements can be used as a benchmark for MRI system functionality and stability, especially when MRI systems are taken out of the radiology suite or laboratory and into less traditional environments.
An integrated target field framework for point-of-care halbach array low-field MRI system design
Authors: de Vos Bart , Remis Rob F. , Webb Andrew G.
Published: May 2023

Objective

Low-cost low-field point-of-care MRI systems are used in many different applications. System design has correspondingly different requirements in terms of imaging field-of-view, spatial resolution and magnetic field strength. In this work an iterative framework has been created to design a cylindrical Halbach-based magnet along with integrated gradient and RF coils that most efficiently fulfil a set of user-specified imaging requirements.

Methods

For efficient integration, target field methods are used for each of the main hardware components. These have not been used previously in magnet design, and a new mathematical model was derived accordingly. These methods result in a framework which can design an entire low-field MRI system within minutes using standard computing hardware.

Results

Two distinct point-of-care systems are designed using the described framework, one for neuroimaging and the other for extremity imaging. Input parameters are taken from literature and the resulting systems are discussed in detail.

Discussion

The framework allows the designer to optimize the different hardware components with respect to the desired imaging parameters taking into account the interdependencies between these components and thus give insight into the influence of the design choices.
Considerations on using MCS and EMS-98 macroseismic scales for the intensity assessment of contemporary Italian earthquakes
Authors: Del Mese S. , Graziani L. , Meroni F. , Pessina V. , Tertulliani A.
Published: May 2023

The concept of macroseismic intensity arose with the purpose of measuring the strength of an earthquake by the effects it causes on buildings, people, and domestic furnishings. From this perspective, buildings can be considered seismic sensors that record the shaking. Early scales were conceived at a time when buildings were mainly in masonry and therefore they could be used as markers of the intensity in case of earthquakes. Indeed, since they were fairly homogeneous, their level of damage could be considered as an indicator of the shaking level. In recent decades, the evolution of construction techniques have made the MCS scale unsuitable for damage assessment of buildings of various resistance. To overcome this problem the EMS-98 scale was designed. Because the MCS scale is still used in Italy, even in the presence of many reinforced concrete buildings, the purpose of this work is to show that the EMS-98 is the most suitable tool for assessing intensity as it is more consistent with the built environment. Theoretical and real intensity assessments, by both MCS and EMS-98, have been determined and compared, showing that nowadays intensity is a function of the vulnerability. MCS and EMS-98 would be comparable only when the building stock is composed of very vulnerable edifices (generally class A). Finally, thanks to the similarity of the two scales for old and vulnerable buildings, EMS-98 appears fully adequate to investigate historical earthquakes and represents a powerful tool to ensure continuity among earthquakes of different epochs.
Quantification of subtype purity in Luminal A breast cancer predicts clinical characteristics and survival
Authors: Kumar Neeraj , Gann Peter H. , McGregor Stephanie M. , Sethi Amit
Published: May 2023

Purpose

PAM50 profiling assigns each breast cancer to a single intrinsic subtype based on a bulk tissue sample. However, individual cancers may show evidence of admixture with an alternate subtype that could affect prognosis and treatment response. We developed a method to model subtype admixture using whole transcriptome data and associated it with tumor, molecular, and survival characteristics for Luminal A (LumA) samples.

Methods

We combined TCGA and METABRIC cohorts and obtained transcriptome, molecular, and clinical data, which yielded 11,379 gene transcripts in common and 1,178 cases assigned to LumA. We used semi-supervised non-negative matrix factorization (ssNMF) to compute the subtype admixture proportions of the four major subtypes—pLumA, pLumB, pHER2, and pBasal—for each case and measured associations with tumor characteristics, molecular features, and survival.

Results

Luminal A cases in the lowest versus highest quartile for pLumA transcriptomic proportion had a 27% higher prevalence of stage > 1, nearly a threefold higher prevalence of TP53 mutation, and a hazard ratio of 2.08 for overall mortality. We found positive associations between pHER2 and HER2 positivity by IHC or FISH; between pLumB and PR negativity; and between pBasal and younger age, node positivity, TP53 mutation, and EGFR expression. Predominant basal admixture, in contrast to predominant LumB or HER2 admixture, was not associated with shorter survival.

Conclusion

Bulk sampling for genomic analyses provides an opportunity to expose intratumor heterogeneity, as reflected by subtype admixture. Our results elucidate the striking extent of diversity among LumA cancers and suggest that determining the extent and type of admixture holds promise for refining individualized therapy. LumA cancers with a high degree of basal admixture appear to have distinct biological characteristics that warrant further study.
Emerging Digital Practices Supporting Student-Centered Learning Environments in Higher Education: A Review of Literature and Lessons Learned from the Covid-19 Pandemic
Authors: Otto Sofie , Bertel Lykke Brogaard , Lyngdorf Niels Erik Ruan , Markman Anna Overgaard , Andersen Thomas , Ryberg Thomas
Published: May 2023

The aim of this paper is two-fold: firstly, to provide an overview of emerging digital practices that support collaborative learning, competency development, and digital literacy for student-centered learning environments in higher education during the rapid digital transition caused by pandemic-related lockdowns across the world, and secondly, to analyze and discuss how systematic reviews of generalized themes and trends can be combined with contextualized experiences and the lessons learned from the Covid-19 crisis to inform the digital transformation of higher education, with a particular focus on bridging the gap between campus-based teaching and online learning and on the identification of the digital competencies that teachers and students must acquire during the continuing shift into a ‘new normal’ for post-pandemic educational practices. This study was motivated by questions and findings emerging from an early reactive case study conducted by three of this paper’s co-authors (Lyngdorf et al., 2021a). By reviewing the full texts of 18 articles, this study provides a systematic literature review which maps the general landscape of the online, hybrid, and blended digital practices applied in existing student-centered learning environments in higher education since the onset of the pandemic. Furthermore, this mapping is used to revisit data and findings from the earlier reactive study of emerging digital practices in a specific problem- and project-based learning (PBL) environment. This study’s findings highlight critical factors and barriers related to emerging practices which support students’ interactions with teachers, content, and each other, as well as the emerging competencies that these practices will require. The paper concludes with a discussion of the main findings and their implications for further research and practice.
Potentially harmful elements pollute soil and vegetation around the Atrevida mine (Tarragona, NE Spain)
Authors: Roca-Perez L. , Boluda R. , Rodríguez-Martín J. A. , Ramos-Miras J. , Tume P. , Roca N. , Bech J.
Published: May 2023

Mining activity is one of the main sources to pollute soil, water and plants. An analysis of soil and plant samples around the Atrevida mining area in Catalonia (NE Spain) was preformed to determine potentially harmful elements (PHEs). Soil and plant samples were taken at eight locations around the mining area. The topsoil (0–15 cm) samples were analysed for physico-chemical properties by standard methods, by ICP-MS for Cd, Co, Cr, Cu, Fe, Ni, Pb and Zn, and were microwave-digested. Plant, root and shoot samples were digested separately, and heavy metals were analysed by AAS. Translocation factor (TF), biological concentration factor (BCF) and biological accumulation factor (BAF) were determined to assess the tolerance strategies developed by native species and to evaluate their potential for phytoremediation purposes. Soil pH was generally acid (5.48–6.72), with high soil organic matter (SOM) content and a sandy loamy or loamy texture. According to the agricultural soil values in southern Europe, our PHEs concentrations exceeded the toxicity thresholds. The highest root content of the most studied PHEs appeared in Thymus vulgaris L. and Festuca ovina L., while Biscutella laevigata L. accumulated more PHEs in shoots. The TF values were > 1 in B. laevigata L., but BAF obtained < 1, except Pb. B. laevigata L., and can be considered potentially useful for phytoremediation for having the capacity to restrict the accumulation of large PHEs amounts in roots and Pb translocation to shoots.
What is the problem and how can we solve it? School authorities’ perceptions of the shortage of teachers in Sweden
Authors: Boström Lena
Published: May 2023

The lack of fully trained teachers is a national challenge in Sweden despite numerous attempts by authorities to approach the issue from a long-term perspective. The proportion of fully trained teachers needs to increase by just over 50% by 2035, and the imbalance will continue for many years to come. Many actors such as the media and politicians have participated in the debate, but not those who are significantly forced to handle, control, and lead in resolving the current situation and who have an overview of the problems at a structural level, namely, the school authorities (school authority in the school system according to the Education Act (Skollagen 2010: 800) can be a municipality, county council, state, or individual who is responsible for the activities in the school. In this text, the most responsible head of a municipality in the educational department has responded to the survey). This study covers 55 school authorities’ views on national tendencies and possibilities of solving this problem using an enactment policy theory. The empirical data are based on a web survey and analyzed through thematic content analysis. The result shows deep concerns about the accelerated problem, the challenges of finding fully trained teachers, and negative attitudes toward the profession. Possible solutions are higher salaries, flexible solutions to becoming teachers, higher status, and better working environments. The school authorities’ perceptions of possible solutions are to some extent consistent with ongoing political initiatives. Neither do they emphasize an overall picture of the working conditions for teachers, nor the far-reaching consequences of all political reforms. In summary, their actions are interpreted as quite re-active, nonlinear, and ad hoc solutions and less proactive perceptions and actions. This can possibly be explained by the fact that the state sets limits on economic initiatives.
Which side are you on? Spider web positioning affects prey capture more than body colour
Authors: Salgado-Roa Fabian C. , Stuart-Fox Devi , Castañeda Edwin , Tique Obando Maira S. , Medina Iliana
Published: May 2023

Colour has been hypothesized to play a crucial role in prey capture for sit-and-wait predators that rely on visual cues to deceive their prey. Prey capture success has been directly linked to colouration in spiders; however, evidence so far focuses mostly on dorsal colouration, excluding ventral patterns that are visible to prey and may be relevant for prey attraction. Here, we explored whether the dorsal and ventral colouration of a colour polymorphic spider is associated with light environment and prey capture success. We quantified the number of prey captured across three dorsal (black, white, and yellow) and two ventral (black and a mosaic yellow/orange pattern) morphs of Gasteracantha cancriformis, considering light intensity on dorsal and ventral sides. We found that spiders capture more prey in low light environments, and that individuals often expose their dorsal colouration towards low light levels. We did not find significant differences in prey capture rate between morphs dorsally or ventrally. These results indicate that how and where spiders position their web can be more important for prey capture than colouration. Alternative hypotheses such as aposematism, camouflage and thermoregulation deserve more attention in future studies that aim to understand the role of colouration in spiders and the factors causing spider colour polymorphisms.
Parent-Child Interactions May Help to Explain Relations Between Parent Characteristics and Clinically Observed Child Autistic Behaviours
Authors: Loncarevic Antonina , Maybery Murray T. , Barbaro Josephine , Dissanayake Cheryl , Green Jonathan , Hudry Kristelle , Iacono Teresa , Slonims Vicky , Varcin Kandice J. , Wan Ming Wai , Wray John , Whitehouse Andrew J. O.
Published: May 2023

The importance of supporting parent-child interactions has been noted in the context of prodromal autism, but little consideration has been given to the possible contributing role of parental characteristics, such as psychological distress. This cross-sectional study tested models in which parent-child interaction variables mediated relations between parent characteristics and child autistic behaviour in a sample of families whose infant demonstrated early signs of autism (N = 103). The findings suggest that associations between parent characteristics (psychological distress; aloofness) and child autistic behaviours may be mediated by the child’s inattentiveness or negative affect during interactions. These findings have important implications in developing and implementing interventions in infancy which target the synchrony of parent-child interaction with the goal to support children’s social communication development.
Examining the Psychosocial and Behavioral Factors Associated with Adolescent Engagement in Multiple Types of Cyberdeviance: Results from an Australian Study
Authors: Brewer Russell , Whitten Tyson , Logos Katie , Sayer Morgan , Langos Colette , Holt Thomas J. , Cale Jesse , Goldsmith Andrew
Published: May 2023

Research has shown that psychosocial and behavioral factors are associated with engagement in a range of deviant behaviors across offline settings. To date, however, very little research has explored the impact of these factors in online contexts. This article addresses this gap by examining the psychosocial and behavioral factors associated with common types of adolescent cyberdeviance. This is accomplished through an empirical study of 327 adolescents enrolled in a high school located in a large Australian city. The study assesses various aspects of psychosocial and behavioral functioning using the Strengths and Difficulties Questionnaire (total difficulties, internalizing problems, externalizing problems, prosocial behavior), as well as numerous types of cyberdeviance relevant to young people, including cyberfraud, cyberhate, cyberviolence, sexting, digital piracy, hacking, and cyberbullying. A series of multivariate logistic regression analyses were conducted to demonstrate the association between psychosocial and behavioral difficulties and various types of cyberdeviance, independent of gender, school grade, socioeconomic status, and engagement in offline delinquency. Results indicate that total difficulties, internalizing problems, and externalizing problems were significantly associated with greater likelihood of engagement in most types of cyberdeviance examined in this study, whereas prosocial behavior was associated with a lower likelihood of engagement in digital piracy only. A discussion of the findings highlights the importance of understanding these factors in a digital context, as well as demonstrating the need to account for them when designing targeted interventions.
Papaverine loaded injectable and thermosensitive hydrogel system for improving survival of rat dorsal skin flaps
Authors: Ibne Mahbub Md Sowaib , Kim Yeong jin , Choi Hwanjun , Lee Byong-Taek
Published: May 2023

Vasospasm during reconstructive microsurgery is a common, uncertain, and devastating phenomena concerning flap survival. Topical vasodilators as antispasmodic agents are widely used to reduce vasospasm and enhance microvascular anastomosis in reconstructive microsurgery. In this study, thermo-responsive hydrogel (CNH) was fabricated by grafting chitosan (CS) and hyaluronic acid (HA) to poly(N-isopropylacrylamide) (PNIPAM). Papaverine, an anti-spasmodic agent, was then loaded to evaluate its effect on rat skin flap survival. Post-operative flap survival area and water content of rat dorsal skin flap were measured at 7 days after intradermal application of control hydrogel (CNHP0.0) and papaverine loaded hydrogel (CNHP0.4). Tissue malondialdehyde (MDA) content and superoxide dismutase (SOD) activity was measured using enzyme linked immunosorbent assay (ELISA) to determine oxidative stress in flaps. Hematoxylin and eosin (H&E) staining and immunohistochemistry (IHC) were performed to evaluate flap angiogenesis and inflammatory markers. Results showed that CNHP0.4 hydrogel could reduce tissue edema (35.63 ± 4.01%), improve flap survival area (76.30 ± 5.39%), increase SOD activity and decrease MDA content. Consequently, it also increased mean vessel density, upregulated expression of CD34 and VEGF, decreased macrophage infiltration, and reduced CD68 and CCR7 expression based on IHC staining. Overall, these results indicate that CNHP0.4 hydrogel can enhance angiogenesis with anti-oxidative and anti-inflammatory effects and promote skin flap survival by preventing vascular spasm.

Graphical Abstract
Breast Cancer Screening Recommendations for Transgender and Gender Diverse Patients: A Knowledge and Familiarity Assessment of Primary Care Practitioners
Authors: Carroll Evelyn F. , Woodard Genevieve A. , St Amand Colt M. , Davidge-Pitts Caroline
Published: May 2023

Breast cancer screening recommendations for transgender and gender diverse (TGD) patients have only been recently developed and many primary care practitioners (PCPs) are unaware of these specific recommendations. The aim of this study is to assess the level of familiarity and knowledge PCPs have with breast cancer screening recommendations for TGD patients. An anonymous survey was distributed to primary care physicians, primary care advanced practice practitioners, and internal medicine and family medicine residents at three academic medical systems in the United States (Mayo Clinic, University of Michigan, University of Texas – Medical Branch). Survey questions assessed the familiarity and knowledge base of TGD breast cancer screening recommendations, training and experience with TGD patients, and basic demographics of the practitioners. Of the 95 survey respondents, only 35% of respondents were aware that breast cancer screening recommendations for TGD patients existed. PCPs who had increased transgender specific health care training and direct clinical exposure to TGD patients demonstrated significantly higher levels of screening recommendation awareness. Two-thirds of respondents received TGD specific medical education during training or medical career and those who had increased transgender specific medical education or direct clinical exposure to TGD patients demonstrated significantly higher levels of screening recommendation awareness. Awareness of breast cancer screening recommendations for TGD patients is low among PCPs and varied based on the practitioner’s prior TGD education and experience. Up-to-date breast cancer screening recommendations for TGD patients should be readily available across multiple platforms, target key audiences, and integrated into transgender health educational curriculums to maximize awareness of these important recommendations.
Migrants from Low-Income Countries have Higher Heat-Health Risk Profiles Compared to Native Workers in Agriculture
Authors: Ioannou Leonidas G. , Testa Davide J. , Tsoutsoubi Lydia , Mantzios Konstantinos , Gkikas Giorgos , Agaliotis Gerasimos , Nybo Lars , Babar Zahra , Flouris Andreas D.
Published: May 2023

The present observational study was conducted to uncover potential differences in the risk of experiencing high occupational heat strain during agriculture work between migrants and their native coworkers, as well as to elucidate the factors that may contribute to such differences. The study took place over the period from 2016 through 2019 and involved monitoring 124 experienced and acclimatized individuals from high-income (HICs), upper-middle-income (UMICs), as well as lower-middle- and low-income (LMICs) countries. Baseline self-reported data for age, body stature, and body mass were collected at the start of the study. Second-by-second video recordings throughout the work shifts were captured using a video camera and were used to estimate workers’ clothing insulation, covered body surface area, and body posture, as well as to calculate their walking speed, the amount of time they spent on different activities (and their intensity) and unplanned breaks throughout their work shifts. All information derived from the video data was used to calculate the physiological heat strain experienced by the workers. The core temperature of migrant workers from LMICs (37.81 ± 0.38 °C) and UMICs (37.71 ± 0.35 °C) was estimated to be significantly higher compared to the core temperature of native workers from HICs (37.60 ± 0.29 °C) (p < 0.001). Moreover, migrant workers from LMICs faced a 52% and 80% higher risk for experiencing core body temperature above the safety threshold of 38 °C compared to migrant workers from UMICs and native workers from HICs, respectively. Our findings show that migrant workers originating from LMICs experience higher levels of occupational heat strain, as compared to migrant workers from UMICs and native workers from HICs, because they take fewer unplanned breaks during work, they work at a higher intensity, they wear more clothing, and they have a smaller body size.
Should expressivists go global?
Authors: Simpson Matthew
Published: May 2023

Moral expressivists think that moral thoughts and sentences don’t represent or describe the world, at least not in any interesting sense. Global expressivists think that no thoughts or sentences represent the world; local expressivists think that some do and others don’t. Huw Price has influentially argued that local expressivism collapses into global expressivism, due both to the effects of minimalist theories of representation and similar concepts, and to an unappreciated consequence of the success of specific expressivist theories like moral expressivism. In this paper I argue that Price’s arguments don’t succeed. While they can be fixed, doing so makes them miss their intended target. Local expressivists should therefore not be worried by Price’s arguments.
Degree completion among students with an immigrant background in short-cycle welfare-oriented professional education
Authors: Hundebo Pål Oskar
Published: May 2023

This article examines degree completion among students with an immigrant background who enrolled in professional bachelor’s degree programmes in early childhood or teacher education, nursing, or social work. By using the high-quality Norwegian register data covering national cohorts of students enrolled in higher education between 1990 and 2014, the analysis indicates that immigrants and native-born descendants of immigrants were less likely to complete these study programmes, compared with native majority students. Explanations for this could be linked to ethnic minorities being inadequately integrated—socially and academically—in these study programmes and therefore less able and/or motivated to stay enrolled until graduation. In all four professional study programmes, students with an immigrant background had comparatively higher probabilities of transferring to other study programmes or dropping out of higher education altogether. On the positive side, minority-majority gaps in degree completion were considerably smaller for those who achieved academically well in these professional study programmes, measured as high first-year GPAs. However, it is quite alarming that immigrants and immigrant descendants who achieved poor academic results were substantially less likely to complete a degree than native majority students with correspondingly poor results.
Real-world clinical outcomes among US Veterans with oral factor xa inhibitor–related major bleeding treated with andexanet alfa or 4-factor prothrombin complex concentrate
Authors: Sutton S. Scott , Magagnoli Joseph , Cummings Tammy H. , Dettling Theresa , Lovelace Belinda , Christoph Mary J. , Hardin James W.
Published: May 2023

Oral factor Xa (FXa) inhibitors significantly reduce incidence of stroke and thromboembolic events in patients with atrial fibrillation or venous thromboembolism. Due to various factors and the lack of a randomized controlled trial comparing andexanet alfa to usual care, non-specific replacement agents including 4 F-PCC are still used off-label for FXa inhibitor bleed management. Clinical and mortality data were extracted from the inpatient medical data and Veteran Affairs (VA) vital status files over the time of March 2014 through December 2020. Propensity score-weighted models were used for this retrospective cohort study using data from the Veterans Affairs Informatics and Computing Infrastructure (VINCI). The study included 255 patients (85-andexanet alfa and 170-4 F-PCC) exposed to an oral factor Xa inhibitor and hospitalized with an acute major, gastrointestinal (GI), intracranial (ICH) or other bleed. In-hospital mortality was significantly lower in the andexanet alfa cohort compared to the 4 F-PCC cohort (10.6% vs. 25.3%, p = 0.01). Propensity score–weighted Cox models reveal a 69% lower hazard of in-hospital mortality for those treated with andexanet alfa (HR 0.31, 95% CI 0.14–0.71) compared to those treated with 4 F-PCC. Additionally, those treated with andexanet alfa had a lower 30-day mortality rate and lower 30-day hazard of mortality in the weighted Cox model (20.0% vs. 32.4%, p = 0.039; HR 0.54, 95% CI 0.30–0.98) compared to those treated with 4 F-PCC. Among 255 US veterans with major bleeding in the presence of an oral factor Xa inhibitor, treatment with andexanet alfa was associated with lower in-hospital and 30-day mortality than treatment with 4 F-PCC.
Influence of substituting soybean meal with moringa seed cake on feed intake, growth performance, digestibility, blood parameters and economics of fattening crossbred calves
Authors: Hassan Ola G.A. , Allak Masouda A. , El-Garhy Gamal M. , Mousa Gamal A.
Published: May 2023

The aim of this study was to investigate the effects of substitution moringa seed cake (MSC) for soybean meal (SBM) in calves’ rations on blood parameters and growth performance. Thirty-two crossbred calves (232 ± 6.75 kg) were divided into 4 groups (8 animals each). All animals were fed a ration of 30% Egyptian clover + 10% corn silage and 60% concentrate mix (CM). The first group (MSC0%) was fed the CM without any MSC (control), while the second (MSC25%), the third (MSC50%), and the fourth (MSC100%) groups were fed on 25%, 50% and 100% MSC by replacing SBM in CM respectively. Results revealed that MSC50% increased (P ≤0.05) most of nutritive values and digestibility compared with the tested groups. Also, MSC50% reduced (P ≤0.05) feed conversion of dry matter (DM), total digestible nutrient (TDN) and digestible energy (DE) compared to the tested groups. Also, MSC50% increased the total weight gain and net revenue by 13.50% and 22.75%, respectively, compared to control. While MSC100% lowered the total weight gain and net revenue by -7.67% and -4.20%, respectively, compared to control. Total protein and glucose were increased (P ≤0.05) by rations with 25% and 50% MSC compared with MSC (0% and100%). Moreover, adding MSC to animals’ rations at different levels improved most of blood metabolites compared to control. Conclusion, moringa seed cake can be used as an alternative protein source to soybean meal in fattening calves rations at level up to 50% to improve growth performance and net profit without adverse effects.
Valorisation of spent tire rubber as carbon adsorbents for Pb(II) and W(VI) in the framework of a Circular Economy
Authors: Bernardo Maria , Lapa Nuno , Pinto Filomena , Nogueira Miguel , Matos Inês , Ventura Márcia , Ferraria Ana Maria , do Rego Ana Maria Botelho , Fonseca Isabel Maria
Published: May 2023

Spent tire rubber-derived chars and their corresponding H3PO4 and CO2-activated chars were used as adsorbents in the recovery of Pb(II) ion and (W(VI)) oxyanion from synthetic solutions. The developed chars (both raw and activated) were thoroughly characterized to have insight about their textural and surface chemistry properties. H3PO4-activated chars presented lower surface areas than the raw chars and an acidic surface chemistry which affected the performance of these samples as they showed the lowest removals of the metallic ions. On the other hand, CO2-activated chars presented increased surface areas and increased mineral content compared to the raw chars, having presented higher uptake capacities for both Pb(II) (103–116 mg/g) and W(VI) (27–31 mg/g) ions. Cation exchange with Ca, Mg and Zn ions was appointed as a mechanism for Pb removal, as well as surface precipitation in the form of hydrocerussite (Pb3(CO3)2(OH)2). W(VI) adsorption might have been ruled by strong electrostatic attractions between the negatively charged tungstate species and the highly positively charged carbons’ surface.

The results shown in this work allow concluding that the valorisation of spent tire rubber through pyrolysis and the subsequent activation of the obtained chars is an alternative and a feasible option to generate adsorbent materials with a high uptake capacity of critical metallic elements.
Alpha-ketoglutarate supplementation and BiologicaL agE in middle-aged adults (ABLE)—intervention study protocol
Authors: Sandalova Elena , Goh Jorming , Lim Zi Xiang , Lim Zhi Meng , Barardo Diogo , Dorajoo Rajkumar , Kennedy Brian K. , Maier Andrea B.
Published: May 2023

Targeting molecular processes of aging will enable people to live healthier and longer lives by preventing age-related diseases. Geroprotectors are compounds with the potential to increase healthspan and lifespan. Even though many of them have been tested in animal models, the translation to humans is limited. Alpha-Ketoglutarate (AKG) has been studied widely in model animals, but there are few studies testing its geroprotective properties in humans. ABLE is a double blinded placebo-controlled randomized trial (RCT) of 1 g sustained release Ca-AKG versus placebo for 6 months of intervention and 3 months follow up including 120 40–60-year-old healthy individuals with a higher DNA methylation age compared to their chronological age. The primary outcome is the decrease in DNA methylation age from baseline to the end of the intervention. A total of 120 participants will be randomized to receive either sustained release Ca-AKG or placebo. Secondary outcomes include changes in the inflammatory and metabolic parameters in blood, handgrip strength and leg extension strength, arterial stiffness, skin autofluorescence, and aerobic capacity from baseline to 3 months, 6 months, and 9 months. This study will recruit middle-aged participants with an older DNA methylation age compared to their chronological age, and test whether supplementation with Ca-AKG can reduce DNA methylation age. This study is unique in its inclusion of biologically older participants.
Finding new purpose for vacancies in rural areas: a taxonomy of coworking space business models
Authors: Thornton Nina , Engert Martin , Hein Andreas , Krcmar Helmut
Published: May 2023

As a result of the rural exodus over the last decades, unused vacancies in rural areas are at risk of falling into disrepair. Given the current trends of flexible workplaces and people returning to rural areas, their repurposing as coworking spaces (CWSs) by entrepreneurs poses a potential for sustainable future-oriented workplace solutions. However, there is little to no guidance on the structural configuration and business models of CWSs in rural areas available for these entrepreneurs. We apply a structured empirical research approach to create a comprehensive and specialized taxonomy, including a literature review and eleven interviews with operators of rural CWSs in Germany. The resulting taxonomy of business models of CWSs in rural areas based on an extension of the business model canvas contributes to the knowledge base on rural CWSs. We evaluate its usability through a case study and an entrepreneurial operator of a rural CWS, underlining its entrepreneurial and practice-oriented purpose. The study addresses several urgent topics, such as the future of work and new work (places), which enable and accelerate the development of CWSs outside agglomerations consequential to the COVID-19 pandemic. It also promotes social and sustainable entrepreneurship and the revitalizing, enhancing, and increasing of digital accessibility of rural regions.
Maternal Immune Activation Induces Cortical Catecholaminergic Hypofunction and Cognitive Impairments in Offspring
Authors: Perez-Palomar Blanca , Erdozain Amaia M. , Erkizia-Santamaría Ines , Ortega Jorge E. , Meana J. Javier
Published: May 2023

Background

Impairment of specific cognitive domains in schizophrenia has been associated with prefrontal cortex (PFC) catecholaminergic deficits. Among other factors, prenatal exposure to infections represents an environmental risk factor for schizophrenia development in adulthood. However, it remains largely unknown whether the prenatal infection-induced changes in the brain may be associated with concrete switches in a particular neurochemical circuit, and therefore, if they could alter behavioral functions.

Methods

In vitro and in vivo neurochemical evaluation of the PFC catecholaminergic systems was performed in offspring from mice undergoing maternal immune activation (MIA). The cognitive status was also evaluated. Prenatal viral infection was mimicked by polyriboinosinic-polyribocytidylic acid (poly(I:C)) administration to pregnant dams (7.5 mg/kg i.p., gestational day 9.5) and consequences were evaluated in adult offspring.

Results

MIA-treated offspring showed disrupted recognition memory in the novel object recognition task (t = 2.30, p = 0.031). This poly(I:C)-based group displayed decreased extracellular dopamine (DA) concentrations compared to controls (t = 3.17, p = 0.0068). Potassium-evoked release of DA and noradrenaline (NA) were impaired in the poly(I:C) group (DA: Ft[10,90] = 43.33, p < 0.0001; Ftr[1,90] = 1.224, p = 0.2972; Fi[10,90] = 5.916, p < 0.0001; n = 11); (NA: Ft[10,90] = 36.27, p < 0.0001; Ftr[1,90] = 1.841, p = 0.208; Fi[10,90] = 8.686, p < 0.0001; n = 11). In the same way, amphetamine‐evoked release of DA and NA were also impaired in the poly(I:C) group (DA: Ft[8,328] = 22.01, p < 0.0001; Ftr[1,328] = 4.507, p = 0.040; Fi[8,328] = 2.319, p = 0.020; n = 43); (NA: Ft[8,328] = 52.07; p < 0.0001; Ftr[1,328] = 4.322; p = 0.044; Fi[8,398] = 5.727; p < 0.0001; n = 43). This catecholamine imbalance was accompanied by increased dopamine D1 and D2 receptor expression (t = 2.64, p = 0.011 and t = 3.55, p = 0.0009; respectively), whereas tyrosine hydroxylase, DA and NA tissue content, DA and NA transporter (DAT/NET) expression and function were unaltered.

Conclusions

MIA induces in offspring a presynaptic catecholaminergic hypofunction in PFC with cognitive impairment. This poly(I:C)-based model reproduces catecholamine phenotypes reported in schizophrenia and represents an opportunity for the study of cognitive impairment associated to this disorder.
Understanding and improving the language of business: How accounting and corporate reporting research can better serve business and society
Authors: Fülbier Rolf Uwe , Sellhorn Thorsten
Published: May 2023

Financial accounting, the core of corporate reporting, is often characterized as the ‘language of business’. Over the last roughly 100 years, and using an evolving set of theories, methods, and data, scholarly work in this area has been contributing to our understanding of this language and how to improve it. This paper seeks, first, to characterize the field with a focus on its evolution in the German-speaking area, where, like elsewhere, normative research traditions interested in improving practice have been making way for positivist approaches that seek a detached understanding of ‘what is.’ Second, we discuss the changing users and institutional parameters that are reshaping corporate reporting, followed by our personal view of ‘wicked’ societal problems and challenges that corporate reporting might be able to help alleviate. Finally, we discuss directions in which research might evolve in order to address these issues, in order to make corporate reporting more useful for serving not only economic actors, but also society and the environment more broadly.