bluuebunny/crossref_metadata_2025 huggingface dataset:
Pasantías como experiencias de articulación entre universidad y escuelas secundarias
Authors: Etcheverry Clara , Araujo Ivana , Ávalos Guillermo , Monti Areco Florencia , Coronel Juan Manuel
Published: December 2023

La organización de nuestro sistema educativo en los diferentes niveles involucra la implementación de mecanismos de articulación a fin de lograr que la transición del nivel medio a la universidad no traiga aparejados inconvenientes o dificultades como consecuencia de cambios marcados, y por lo tanto, altos índices de desgranamiento. Desde el grupo de Investigación de Biología de los Invertebrados y Protistas se ha trabajado desde el año 2013 con docentes de distintas instituciones a fin de realizar actividades que vinculen a los alumnos de nivel secundario con la universidad. En este sentido, se realizaron pasantías con alumnos de los últimos años de cuatro colegios de Corrientes Capital, cuyas actividades consistieron en el diseño de trabajos de investigación, desarrollo de habilidades para la obtención de material biológico, uso de métodos y técnicas de investigación en el ámbito biológico. Como resultado de estas pasantías se reafirmó la importancia de este tipo de actividades en el fortalecimiento, no solo de la enseñanza de la Biología, sino también en el desempeño actitudinal de los alumnos, logrando establecer lazos de confianza que otorgan una mayor seguridad a la hora de iniciar la vida universitaria. Por lo tanto, el objetivo de este trabajo fue plasmar las experiencias realizadas en este contexto, y que sean el puntapié para realizar nuevas propuestas donde se pueda acrecentar esta relación de articulación entre ambos niveles.
Diseño y construcción de una precámara destinada al control de temperatura del aire para el secado solar de vegetales de alimentación fisiológica saludable
Authors: Spotorno Rubén , Pochettino Juan , Ambrosig Ricardo , Pinatti Gianfranco , Vargas Orlando , Veppo Juan , Figueredo Gustavo
Published: December 2023

En el presente trabajo se expone el diseño y construcción de un equipo experimental destinado al secado solar de vegetales de alimentación fisiológica saludable. Se presenta el diseño y construcción de una precámara, donde se realiza el control de la temperatura del aire, antes de su ingreso a la cámara de secado propiamente dicha. El control automático de la temperatura del aire se realiza utilizando una placa arduino y hardware de bajo costo. El diseño de los diferentes componentes de la precámara se realizó utilizando el software SolidWorks, y luego se utilizó la tecnología de fabricación aditiva (impresión 3D), para su construcción y posterior ensamblado. Los primeros ensayos realizados del control de la temperatura del aire fueron alentadores, permitiendo encontrar un sistema muy sencillo y de bajo costo.
Herbal food supplements usage awareness of university students: Example of Echinacea and St. John's Wort
Authors: İDUĞ Tuğba
Published: December 2023

In recent years, usage of food supplements (Fs) has increased in order to maintain healthy living, have well-being, and be protected from the diseases. There are many medicinal plants used as herbal food supplements (HFs). Within the scope of this study, Echinacea and St. John’s Wort were selected among the plants that are frequently encountered. This descriptive, cross-sectional study was conducted through completing a self-administered online questionnaire by health students. The questionnaire was filled out by 211 students studying at the faculties of Medicine, Dentistry, Pharmacy and Health Sciences at Istanbul Medipol University. The greatest participation was achieved with Pharmacy students (47.4%), whereas the lowest participation was reached with Dentistry students (5.7%). The most commonly used products as Fs were vitamin D (21.3%) and multivitamins (16.1%), while the use of HFs was 8.5%. St. John’s Wort is commonly preferred for wound and burn treatment and Echinacea is used to boost immunity. In parallel with this use, St. John’s Wort is preferred as olive oil maceration and Echinacea as herbal infusion. While the use of HFs was 58.3%, that of the Fs were 44.5%. Echinacea use was found to be 14.4% and St. John’s Wort was 31.3%. The relationship between the presence of chronic disease and the use of Fs or HFs was not statistically significant. This study is significant to detect the opinions and knowledge levels of health students about Fs, especially HFs, St. John’s Wort and Echinacea, which are available in the market.
The isolation and characterization of bacteria isolated from Capnodis tenebrionis L. and their biological control potential against some insect pests
Authors: GÜNEY AYDIN Ebru , SEZEN Kazım
Published: December 2023

Capnodis tenebrionis L. (Coleoptera: Buprestidae) is one of the most destructive pests of stone fruit orchards in several countries, including Türkiye. In the present study, 21 bacterial isolates were isolated from the larvae and adults of C. tenebrionis. The morphological, physiological, biochemical and molecular characteristics of the bacterial isolates were determined. The bacterial flora isolated from C. tenebrionis was as follows: Bacillus cereus, B. mycoides, B. pumilus, Paenibacillus xylanilyticus, B. flexus, B. simplex, Raoultella terrigena, Enterobacter cloacae, Klebsiella oxytoca, B. safensis, B. amyloliquefaciens and B. aryabhattai. The biological control potential of these bacterial isolates against the larvae of several economic pest species, the elm leaf beetle (Pyrrhalta luteola (M.)), the honeycomb moth (Galleria mellonella L.), and the mealworm (Tenebrio molitor Ludwig), was investigated. The isolates of B. cereus showed the highest efficacy against these insect pests.
MODERN APPROACHES TO THE TREATMENT OF BRONCHIAL ASTHMA ACCORDING TO GINA 2023
Authors:   SO “National institute of phthisiology and pulmonology named after F. G. Yanovsky NAMS of Ukraine”, Feshchenko Yu. I. , Polianska M. O.
Published: December 2023

In 1993 there was initiated the Global Initiative for Asthma Management and Prevention. Each year GINA is revised and each subsequent revision contains updated recommendations based on new data. It’s underlined in red throughout GINA 2023 the significance of ICScontaining therapy. The best treatment approach for adults and adolescents remains Track 1 with ICS/formoterol as needed. Track 2 now also includes an ICS/SABA combination as needed as an Anti-inflammatory Reliever (AIR), but Track 1 remains the “preferred” regimen. Although inhaled SABA are highly effective for rapid relief of asthma symptoms, patients whose asthma is treated with SABA alone (compared with ICS) have an increased risk of death and asthma-related emergency medical care needs. For safety reasons, GINA does not recommend SABA alone for the treatment of asthma in adults, adolescents, or children 6–11 years of age. Is it possible to treat asthma without SABA? In an asthma center in Argentina, since 2014, a treatment strategy with ICS-containing symptom relievers has been implemented: using only budesonide/formoterol in a single inhaler across all spectrums of asthma severity and completely excluding the use of SABA. As a result, the level of hospitalization decreased by 92%. The 2023 revision of GINA proposed new terminology for anti-asthma drugs: Maintenance therapy, controller drugs, reliever drugs, anti-inflammatory reliever, Maintenance and Reliever Therapy - MART. Clarifications have been made for the treatment of asthma exacerbations. Added details on drugs and doses of ICS/formoterol on demand and ICS/SABA as needed, MART regimen in individual asthma action plan, how and when to modify these drugs as the disease worsens. The inhaler prescription algorithm is written in more details, considering its impact on the environment. Conclusions: The GINA 2023 updates highlight the most significant role of ICS-containing therapy in achieving asthma control and preventing exacerbations. However, patient adherence to therapy remains quite low, so an approach that allows for the management of both symptoms and exacerbations simultaneously is simpler and remains the preferred way of asthma therapy. Global approaches to asthma management - limiting, where possible, the use of SABA and favoring delivery devices and treatment regimens with less environmental impact. Managing the patient according to his personal action plan and creating local protocols can limit the use of SABA, improve the patient’s asthma outcomes and environmental impact. Key words: asthma, GINA, inhalers, asthma control, exacerbation
SELMAN ABRAHAM WAKSMAN, BORN IN UKRAINE — AN OUTSTANDING SCIENTIST, A NOBEL LAUREATE, THE DISCOVERER OF STREPTOMYCIN AND THE MODERN ERA OF ANTI-TUBERCULOSIS CHEMOTHERAPY
Authors:   SO “National institute of phthisiology and pulmonology named after F. G. Yanovsky NAMS of Ukraine”, Opimakh S. G.
Published: December 2023

Throughout its existence, humanity has experienced both evolution and progress in health matters and borne the burden of complex diseases and shortened life duration. Tuberculosis is an example of a pathology that until recently was a sentence for the patient. Every successful step in the search for tuberculosis treatment (which means saving a life) is priceless. The aim was to study of the biography of Selman Waksman and the history of the streptomycin discovery according to the literature data. Selman Waksman was born in 1888 in a Ukrainian village near Vinnitsa, and immigrated to the United States in 1910. He received a bachelor’s degree in 1915, and in 1916 — a magister degree in the agricultural course of Rutgers College. In 1918, Selman received Ph.D. in Biochemistry in the University of California. Since 1918, he worked in the Department of Soil Microbiology at Rutgers University and studied actinomycetes. In 1923, Waksman discovered that certain actinomycetes produced substances toxic to bacteria, and in 1939 he began an extensive research program to determine the nature of the substances by which various soil microbes destroyed each other. Actinomycin, an effective but toxic antibiotic, was isolated in 1940. In 1942, the antibiotic streptothricin was discovered and studied, a highly active against the M. tuberculosis, but too toxic. In 1943, together with graduate student Albert Schatz, two strains of Actinomyces were isolated, which produced a substance with antibiotic activity — streptomycin. Streptomycin had shown antibiotic activity against several bacteria, including M. tuberculosis. The drug was not toxic to animals. The great practical prospects of streptomycin for the treatment of tuberculosis and other infections led to the award of the Nobel Prize in Physiology or Medicine in 1952. Dr. Waksman introduced and popularized the term “antibiotic” in microbiology. He published more than 447 articles and wrote, independently or with co-authors, 28 books. When the Nobel Prize was awarded to the developer of streptomycin, a drug that saved thousands of human lives, the outstanding scientist was recognized as one of the greatest benefactors of mankind. Key words: Selman Abraham Waksman, streptomycin, tuberculosis, history of medicine.
Citizen satisfaction in the service delivery of city corporations in Bangladesh
Authors: Mahmud Rifat
Published: December 2023

Citizen satisfaction in service delivery is an essential indicator in the governance mechanism involving the level of confidence that citizens have towards the local government institutions. The present study aims to find out the level of citizens’ satisfaction with urban local government institutions, i.e., city corporations in Bangladesh. The study seeks to identify the factors that can explain the variations in citizens’ satisfaction level in urban local government institutions. The study adopted a quantitative approach based on the survey data, which involved the opinions of 2,160 respondents from all 12 city corporations in the country. The study found that, first, citizens’ level of satisfaction in city corporations is low. Second, the public responsiveness variable involving the speed and accuracy of city corporations in service delivery has the strongest overall effect on variations in citizens’ satisfaction. Third, the service quality variables, along with the prior experience determinants involving timeliness and promptness in giving services, act as a determining variable affecting satisfaction in city corporations. The contribution of this study lies in its pointing out some new directions to better explain the level of citizen satisfaction towards city corporations in Bangladesh.
Proiect seminar psihologie cognitivă
Authors: Ariana Pop Timeea , Claudia Chiș Măriuca , Hasas Beatrice Angela , Sabina Lukacs
Published: December 2023

Rolul mecanismelor de control cognitiv în atenția selectivă față de stimulii emoționali constituie un domeniu de cercetare care poate avea aplicații în perspectivă psihologică prin prisma înțelegerii modului în care mecanismele de control cognitiv ne influențează atenția la stimulii emoționali, dar și din punct de vedere cognitiv oferind un punct de pornire spre înțelegerea modul în care procesele noastre cognitive, cum ar fi atenția și controlul executiv, interacționează cu experiențele noastre emoționale.
The Misperception of Organizational Racial Progress Toward Diversity, Equity, and Inclusion
Authors: Torrez Brittany , Hollie LaStarr , Richeson Jennifer , Kraus Michael W.
Published: December 2023

Despite a checkered racial history, people in the US generally believe the nation has made steady, incremental progress toward achieving racial equality. In this paper, we investigate whether this US racial progress narrative will extend to how the workforce views the effectiveness of organizational efforts surrounding diversity, equity, and inclusion (DEI). Across three studies (N = 1,776), we test whether Black and White US workers overestimate organizational racial progress in executive representation. We also examine whether these misperceptions, surrounding organizational progress, drive misunderstandings regarding the relative ineffectiveness of common organizational diversity policies. Overall, we find evidence that US workers largely overestimate organizational racial progress, believe that organizational progress will naturally improve over time, and that these misperceptions of organizational racial progress may drive beliefs in the effectiveness of DEI policies.
PENGARUH METODE PROYEK TERHADAP PERILAKU KERJASAMA ANAK DI TAMAN KANAK-KANAK
Authors:   niversitas Negeri Padang, Pendidikan Guru-Pendidikan Anak Usia Dini, Afrisna Amelia
Published: December 2023

Perilaku kerjasama anak belum berkembang secara optimal karena kurang menariknya pemilihan metode yang digunakan guru. Sebagian besar guru kurang memperhatikan pentinya pemilihan meotde yang menarik dan menyenangkan sehingga terciptanya perilaku kerja sama anak. Maka demikian penelitian ini guna menjawab permasalahan yang ada berdasarkan identifikasi masalah yaitu seberapa besar pengaruh metode proyek terhadap perilaku kerja sama anak di Taman Kanak-kanak. Penggunaan metode Quasi Eksperimen pretest-postest sebagai metode penelitian ini berdasarkan populasi penelitian mencakup seluruh peserta didik TK Aisyiyah 11 dengan jumlah sampel sebanyak 17 anak yang meliputi atas dua kelompok (eksperimen dan kontrol). Analisis data penelitian mengacu pada uji prasyarat normalitas, homogenitas dan uji hipotesis. Hasil penelitian yang telah dilakukan menunjukkan bahwa perolehan signifikansi (2-tailed) sebesar 0,001<0,05. Dengan rata-rata N-gain metode proyek membuat taman mini sebesar 19,88 dan penggunaan media balok sebesar 18,29, perilaku kerjasama anak perlakuan dengan metode proyek lebih tinggi dibandingkan dengan kerjasama perilaku anak yang menggunakan media balok. Sehingga dapat disimpulkan bahwa metode proyek berpengaruh sangat besar terhadap perilaku kerja sama anak di Taman Kanak-kanak Aisyiyah 11 Kalumbuk Kota Padang.
Implementation of Gifted Curriculum Applying Response to Intervention Model
Authors:   The Education Research Institute, Choi Byung Yeon
Published: December 2023

The Response to Intervention Model (RTI), which appeared to correct the weaknesses of students with learning problems, is expanding its scope of application. In this study, I explored whether RTI can be applied to the implication of the gifted and talented curriculum. According to this study, the basic principles of RTI, such as universal screening, team-oriented approach, progress monitoring, early identification and intervention, and multi-tiered intervention system, can be applied to the operation of a curriculum for the development of giftedness and talent. In addition, the main models of the gifted and talented curriculum (SEM, ICM, LoS, ALM) and RTI can be integrated and used. The gifted and talented curriculum can be designed and implemented according to the intervention stages of RTI. At this time, the stage consists of three stages, and activities for enhancing students' strengths are differentiated for each stage. In order to effectively utilize RTI in gifted education, not only teacher expertise is required, but also empirical research to verify the effectiveness of the operation must be conducted.
Definir el valor de Ca 125 para predecir citorreducción óptima en pacientes con cáncer epitelial de ovario
Authors: Medina Bueno Gonzalo Arturo , Quiñonez Barra Rocío Karina , Ticona Ramos Deyne Maribel
Published: December 2023

Objetivo. Definir el valor de Ca 125 para predecir citorreducción óptima enpacientes con cáncer epitelial de ovario. Métodos. Estudio observacional, analítico yretrospectivo de 52 pacientes consecutivas intervenidas de cáncer de ovario epitelialen estadio clínico III y IV y que no recibieron quimioterapia preoperatoria, entreenero de 2014 y diciembre del 2018 en el Servicio de Ginecología del Hospital CarlosAlberto Seguín Escobedo, Arequipa, Perú. Se determinó sensibilidad, especificidad,valor predictivo positivo y negativo, y el área bajo la curva ROC del punto de cortede Ca 125 más adecuado para citorreducción óptima. Resultados. Las pacientestuvieron en promedio 58 años de edad, el subtipo histológico seroso fue el másfrecuente con 73,1%, el estadio clínico IIIC correspondió a 65,4% de casos y se logrócitorreducción óptima en 61,5% de las pacientes. La curva ROC alcanzó 78% con Ca125 de 716,7 U/mL como el mejor punto de corte de predicción de citorreducciónóptima, con sensibilidad de 75%, especificidad 75%, valor predictivo positivo 82,8% yvalor predictivo negativo 65,2%. Conclusión. El marcador tumoral Ca 125 resultó útilen la predicción de citorreducción óptima en pacientes intervenidas de cáncer deovario epitelial, siendo el mejor punto de corte 716,7 U/mL.
Occurrence of adult acquired flat foot among diabetic patients in Rawalpindi and Islamabad: a cross-sectional descriptive study
Authors: YOUNİS Ateeqa , ASHFAQ Madiha , WAHEED Faiza , FAROOQ Onaisa , ASHRAF Aliya , GHAYOUR Laiba , IQBAL Haniya , SABA Annam
Published: December 2023

Human foot is a biological masterpiece, which is strong enough to support the body weight and flexible enough to adjust to various surfaces. Foot postural deviation can alter the alignment of the entire body. The collapse of the medial longitudinal arch of the foot causes one of the most prevalent deformities i.e. flat foot. Diabetic patients are more prone to have flat foot due to degeneration of posterior tibial tendon over the course of their disease. The aim of this study was to determine the occurrence of adult acquired flat foot and assess the disability of flat foot among diabetic population in Rawalpindi and Islamabad, Pakistan. In this cross-sectional descriptive study, 384 diabetic patients aged 35-60 year were enrolled after obtaining informed consent. Non-probability convenience sampling technique was employed. The data was gathered by performing navicular drop test to determine the presence of flat foot, assessment of posterior tibial tendon dysfunction through single heel rise test and by using foot function index questionnaire to assess pain, disability and activity limitation. Based on results of the study, posterior tibial tendon dysfunction was observed to cause the appearance of low navicular height leading to flat foot in 58.33% of the population. Moreover, there is a moderate tendency of occurrence of flat foot among diabetic population in the absence of other risk factors such as hypertension, obesity, steroids use and previous foot trauma etc. With regard to the functionality measured by foot function index, it was implied that the functional status of the patient was reduced because of the pain, disability and activity restriction in the presence of flat foot.
Effects of Temperature on Process Efficiency and Oil Color in Hazelnut Oil Extraction with Screw Machine
Authors: GÜLER Birkut , KARAOSMANOĞLU Hasan
Published: December 2023

This study was carried out in order to determine the color values of the oils obtained by the oil extraction machine at different temperatures, and the press and energy efficiency of the device. For this purpose, the oils were extracted from Giresun Quality (GQ) and Levant Quality (LQ) hazelnuts by pressing at 5 different temperatures (i.e. cold pressed, 50 °C, 100 °C, 150 °C and 200 °C). The color values of the obtained oils were measured with the HunterLab Color Flex EZ colorimeter device. According to the results, while the oil amount increased with an increase in temperature up to 100 °C in GQ, the extracting time decreased. For LQ, on the other hand, while the extracting time increased with the increase in temperature, the amount of oil obtained decreased. In terms of energy efficiency, the most suitable pressing temperature was determined as 100 oC for GQ and room temperature (20 0C) for LQ. Also, a significant decrease was observed in L* (brightness), b* (yellowness) and color intensity (C*) values with increasing temperature, and a serious color difference (ΔE) emerged in relation to this decrease. In addition, no significant change was observed in a* (redness) and H° (color tone) values (p>0.05). When the change of the efficiency of Giresun quality and Levant quality hazelnuts with temperature in the oil extraction process by the helix method was examined, different results were obtained. While the efficiency increased with higher temperature in Giresun quality hazelnuts, the efficiency increasement with temperature in Levant quality was not observed.
A Fuzzy Numerical Simulation-based Heuristic Method for Fully Fuzzy Systems of Linear Equations
Authors: GÜNAY AKDEMİR Hande
Published: December 2023

In this paper, a new method is proposed to find the approximate solutions to fully fuzzy systems of linear equations (FFSLEs). The technique integrates a bisection method with Fuzzy Numerical Simulation (FNS). The procedure starts with generating single values of fuzzy parameters and solving the resulting crisp problems repeatedly to determine the lower and upper bounds of the solutions. After computing the mean lower and upper bound values, the obtained supremum and infimum values are considered to be the lower and upper bounds of the solutions, respectively. It is attempted to improve solutions by considering an error function related to the sum of the absolute differences between the corresponding lower and upper bounds of the left and right sides of the equalities. When very large intervals are obtained for the solutions, the bisection algorithm is applied to reduce the error value. The method intends to solve square systems of large dimensions for arbitrary fuzzy numbers (FNs) by removing non-negativity confinements of the variables and/or coefficients to be more realistic. After the computational method is presented thoroughly, some benchmark examples are finally provided.
Application of QMSA Method for Al 0.3 Ga 0.7 N/GaN HEMT Structure
Authors: BİLGİLİ Ahmet , AKPINAR Ömer , KAYA Naki , ÖZTÜRK Mustafa
Published: December 2023

In this study, Al 0.3 Ga 0.7 N/GaN high electron mobility transistor (HEMT) structure is grown on a sapphire (Al2O3) substrate by using metal-organic vapor phase epitaxy (MOVPE), and its electron transport and magnetic transport properties are investigated. Resistivity is measured in the 20-350 K temperature range. Hall mobility and Hall carrier concentration are measured in the 0-1.5 T magnetic field range and the same temperature range. Magnetic transport properties are analyzed using quantitative mobility spectrum analysis (QMSA). 2DEG and 3DEG transport mechanisms are separated by using QMSA results.
Hava Kalitesi Parametreleri (PM10 ve SO2) Kullanılarak Hava Kirliliği Riskli Bölgelerin Zamana Bağlı Konumsal Analizi: Kocaeli İli Örneği
Authors: MEMİŞOĞLU BAYKAL Tuğba
Published: December 2023

Bu çalışmada, Kocaeli İl’inin hava kalitesi parametrelerinin CBS tabanlı konumsal-zamansal sıcak nokta kümeleme analizleri gerçekleştirilerek hava kirliliği açısından riskli bölgeler tespit edilmiştir. Bu bağlamda, Çevre, Şehircilik ve İklim Değişikliği Bakanlığı’nın Ulusal Hava Kalite İzleme Ağın’dan Kocaeli iline ait 2021-2022 yılları arasında kaydedilen Partikül madde (PM10) ve Kükürt dioksit (SO2) hava kalitesi parametreleri aylık ortalama değerler şeklinde temin edilerek düzenlenmiştir, konumla ilişkilendirilmiştir. Çalışmada, öncelikle kullanılan verilerin mekânsal otokorelasyon analizleri yürütülerek kümeleme eğilimi gösterip göstermediği tespit edilmiştir ve analizler için gerekli mesafe değerleri belirlenmiştir. Ardından, klasik nokta kümeleme analizlerinden sıcak nokta analizi (Getis Ord Gi*) ve analizlerde zamanı da esas alan gelişen sıcak nokta analizi (Emerging Hot Spot Analizi) yürütülmüştür. Sonuçlar, gelişen sıcak nokta analizlerinin, klasik sıcak nokta kümeleme analizlerine göre daha kolay ve hızlı bir analiz sağladığını, ayrıca herhangi bir zaman aralığına dayalı analizleri tek bir seferde değerlendirebilmenin kolay yönünü ve farklı konumlarda daha çok hava kirliliği sıcak noktalarının tespit edildiğini ortaya koymuştur.
Morphometric Diversity for Rootstock Characteristics of Turkish Hazel (Corylus colurna L.) Populations in The Western Black Sea Region of Türkiye
Authors: İSLAM Ali , AYAN Sezgin , TURAN Ali , YILMAZ Muharrem , KARAGOL Selim , ÇOLAK Salih
Published: December 2023

The Turkish hazel (Corylus colurna L.) is native to Türkiye, where it is found only in small, scattered, and isolated populations within its natural distribution area. These remaining populations are of critical importance for conservation, for continued use as a natural reservoir, and natural selection. The trees are up to 400 years old and already well-adapted to harsh environmental conditions. In recent years, this species has drawn the attention of agriculture and forest practitioners and scientists in several countries who use this important and valuable tree species in studies of the effects of climate change. The origin and genotype of the reproductive material of this species play a key role in its adaptation to environmental conditions, and possible cultivation. The purpose of this study is to reveal the variation of genotypes selected from 13 different populations in Kastamonu and Bolu provinces in terms of rootstock characteristics. These regions are the locations where the Turkish tree hazel is most abundant. For this aim, the growth habit, vigor, number of suckers, and internode of one-year-old shoots were scored on the parent trees. A Kruskal Wallis-H test was applied to the non-parametric data to determine if there were differences among the populations for each variable and the total number of points. Then the Mann-Whitney-U test was used for differences among the groups. In addition, the phylogenetic relationship among the populations and genotypes was revealed by Cluster analysis. Among the rootstocks scored, KTU3 and KTU64 provided the highest score according to non-suckering and strong growth. It has been observed that individuals in Turkish hazelnut populations generally do not form suckers (%89.4) and show strong growth. C. colurna trees were observed to be individual and scattered in the population. Most of the trees are elderly and need to be protected in situ. Turkish hazel population will play a key role in production and sustainable such as to develop rootstock and variety in agriculture production, sustainable forest development, and for ecological adaptation in climate change scenarios.
Anatomical Features of Vegetative Organs of Primula auriculata Lam. (Primulaceae)
Authors: ERGEN AKÇİN Öznur , ÖZTÜRK Şükran , ŞENEL Gülcan
Published: December 2023

The aim of this study was to investigate the anatomical characteristics of Primula auriculata, known as 'felçotu'. Anatomical studies were carried out on vegetative organs fixed in 70% alcohol. Sections were stained with a mixture of Safranin/fast green (1/9). The plant has a primary root structure. The root has prominent endodermis and pericycle layers. The stem is rhizome shaped. The vascular bundles are ring-shaped in the center of the rhizome. The leaf is dorsiventral and amphistomatic. There are idioblast cells in all investigated structures of the species. The stomatal index is 14.2 on the upper surface of the leaf and 18.4 on the lower surface.
Investigating the Relationship Between Creep Rate, Thermal Conductivity and Enthalpy of Mixing in Some Magnesium Alloys
Authors: TÜRE Yiğit
Published: December 2023

Magnesium (Mg) and its alloys are known for their high specific strength, but they have limitations that need to be addressed to expand their range of industrial use. One major limitation is their high temperature performance, which requires improvement for them to be used in industries such as aviation where creep resistance is important. In this study, we investigated the creep behavior of several Mg alloys, including the commercially used AZ series (AZ31, AZ61, and AZ91), as well as the AM50, AX52, and AE42 alloys. We studied the relationship between the creep rate of these alloys and two material properties: thermal conductivity and enthalpy of mixing. By analyzing these properties, we can compare and evaluate newly developed or existing alloys in terms of their creep behavior. When the obtained results are interpreted in general, a linear relationship is found between the creep rate, thermal conductivity and enthalpy of mixing as a general trend.
ISO 31000 Risk Yönetimi Çerçevesi ve ALARP İlkesi Kullanılarak Yeni Bir Gıda İşleme Tesisinin Risklerinin Değerlendirilmesi
Authors: KARA Betül , CANBAZ Minel , DOĞHAN Ezgi Sude , AYYILDIZ Ertuğrul
Published: December 2023

Risk analizi ve yönetimi, işletmelerin karşılaşabilecekleri olası tehlikeleri belirleyerek bu risklere etkin bir şekilde yanıt verme sürecidir. Risk analizi ve yönetimi, organizasyonların daha iyi kararlar vermesini, operasyonel verimliliği artırmasını ve kriz durumlarına hazırlıklı olmasını sağlar. Ayrıca, risklerin önceden belirlenmesi ve uygun önlemlerin alınması, finansal kayıpların azaltılmasına ve itibarın korunmasına yardımcı olur. Aynı zamanda, kriz durumlarına hazırlıklı olmayı ve itibarın korunmasını sağlar. Bu süreç, riskleri tanımlama, analiz etme, önceliklendirme ve uygun önlemleri alma adımlarını içerir. Risk analizi, organizasyonun faaliyetleri ve hedefleri dikkate alınarak potansiyel tehlikelerin belirlenmesini sağlar. Ardından, riskler önceliklendirilerek en yüksek önceliğe sahip olanlara öncelik verilir ve riskleri azaltmak veya ortadan kaldırmak için uygun önlemler alınır. Bu çalışmada yeni bir gıda işleme tesisi için risk analizi uygulaması gerçekleştirilmiştir. Bu kapsamda tesisin karşılaşması muhtemel riskler belirlemiştir. Belirlenen riskler iş sağlığı ve güvenliği açısından olabileceği gibi yeni bir tesis üzerine çalışılması sebebiyle sektörden kaynaklanan riskler de olabilir. Çalışma kapsamında literatürde bulunan çeşitli risk değerlendirme yöntemlerine başvurulmuştur ve elde edilen sonuçlar ile hedeflendiği gibi risklerin yönetilmesi sağlanmıştır.
Kimyasal Çöktürme Yöntemiyle Persülfat Aktivasyonu için Aktif Karbon Destekli Demir ve Kobalt Bazlı Katalizör Sentezi ve Eritromisin Degradasyonu için Uygulaması
Authors: ERDEM Hatice , ERDEM Mehmet
Published: December 2023

Kalıcı organik kirleticilerin sucul ortamlardan ileri oksidasyon yöntemleriyle giderimi için etkili, ekonomik ve çevre dostu heterojen katalizörlerin geliştirilmesi son zamanlarda oldukça önem kazanmıştır. Bu çalışmada, aktif karbon (AC) destekli demir (CP-Fe) ve kobalt (CP-Co) bazlı katalizörler kimyasal çöktürme yöntemiyle hazırlanmıştır. Hazırlanan katalizörler FTIR, FESEM, EDX-haritalama, XRD, pHpzc, Boehm titrasyonu ve BET yüzey alanı teknikleri kullanılarak karakterize edilmiştir. AC destekli CP-Fe ve CP-Co katalizörlerin spesifik yüzey alanlarının sırasıyla 396.42 ve 441.76 m2/g olduğu ve her iki katalizörün de mezo gözenekli bir yapıya sahip olduğu belirlenmiştir. Demir ve kobaltın AC yüzeyine homojen bir şekilde yayılmış olduğu, demirin manyetit (Fe3O4) ve kobaltın ise amorf yapıda olduğu tespit edilmiştir. Katalizörlerin katalitik aktiviteleri, persülfat aktivasyonu ile eritromisin (ERY) degradasyonunda test edilmiştir. CP-Fe katalizör varlığında ERY 60 dk’da %96 oranında degrede olurken, CP-Co katalizör varlığında 30 dk içinde tamamen degrede olmuştur. Her iki katalizörün de adsorpsiyon ve degradasyonun birlikte sinerjik etkisiyle ERY’yi parçalamada ve gidermede yüksek katalitik aktivite gösterdiği belirlenmiştir.
Ag/pentasen/Cu MIM Yapısının Optoelektronik Özelliklerinin İncelenmesi
Authors: ÜNAL Fatih
Published: December 2023

Ag/pentasen/Cu MIM yapısı (metal-insulator-metal) termal buharlaştırma yöntemi kullanılarak başarılı bir şekilde üretilmiştir. Üretilen yapının temel I-V karakterizasyonu karanlık ve 20, 40, 60, 80, 100 mW.cm-2 ışık şiddetinde incelenmiştir. MIM yapısının diyot parametreleri; idealite faktörü (n), engel yüksekliği (ϕb), ters doyma akımı (I0), seri direnç (Rs) ve Shunt direnç (Rsh) değerleri hem karanlık hem de farklı ışık şiddetlerinde belirlenmiştir. Karanlık ortamda sırasıyla n, ϕb, I0, Rs ve Rsh değerleri 7.95, 0.31 eV, 1.95x10-6 A, 3.13x104 Ω ile 3.85 x104 Ω olduğu belirlenmiştir. Ayrıca üretilen MIM yapısının fotodedektör parametreleri; fotoakım (Iph), duyarlılık (R) ve özgül dedektiflik (D*) değerleri de farklı ışık şiddetlerinde incelenmiştir ve maksimum değerlerin sırasıyla 7.85x10-5 A, 6.09x10-3 A.W-1 ve 1.86x107 Jones olduğu belirlenmiştir.
Solution of Some Integral Equations by Point-Collocation Method
Authors: DURAK Birkan , ÖZER Hasan Ömür , KAPKIN Şule , YILDIZ Hüseyin
Published: December 2023

In several engineering or physics problems, particularly those involving electromagnetic theory, thermal and radiation effects, acoustics, elasticity, and some fluid mechanics, it is not always easy or possible to find the analytical solution of integral equations that describe them. For this reason, numerical techniques are used. In this study, Point-collocation method was applied to linear and nonlinear, Volterra and Fredholm type integral equations and the performance and accuracy of the method was compared with several other methods that seem to be popular choices. As the base functions, a suitably chosen family of polynomials were employed. The convergence of the method was verified by increasing the number of polynomial base functions. The results demonstrate that the collocation method performs well even with a relatively low number of base functions and is a good candidate for solving a wide variety of integral equations. Nonlinear problems take longer to calculate approximate solution coefficients than linear problems. Furthermore, it is necessary to use the real and smallest coefficients found in order to obtain a suitable approximate solution to these problems.
Sujeito em cenas: pesquisa (auto)biográfica e a Pedagogia Congadeira
Authors: Lima Rafael Honorato de , Seithi Kato Danilo
Published: December 2023

Resumo

As narrativas por aqui transcritas tratam-se de um recorte metodológico que se origina de uma pesquisa (auto)biográfica dialogada em cenas, intitulada Pedagogia Congadeira: Germinações de uma Proposta para Educação das Relações Étnicos Raciais. Tecemos esse artigo a partir dos questionamentos: A (auto)biografia pode auxiliar no desbravamento e formação do sujeito? Como a metodologia (auto)biográfico em cenas contribui para estabelecimento de uma Pedagogia Congadeira? Objetivando analisar e compreender as possiblidades/potencialidades do método (auto)biográfico na formação do sujeito, propondo a reflexão sobre os fundamentos da pesquisa (auto)biográfica com transição em cenas e as suas possíveis contribuições para estabelecimento da Pedagogia Congadeira, sendo elementos que se complementam para uma melhor compreensão de dimensão da realidade pesquisada, ciclo espiralado que cingem do individual ao coletivo,  desbravando espaços e tempos educacionais do sujeito (auto)biográfico, tendo como atores principais a Congada e o Congadeiro, efetivando dispositivos da Lei 10.639/2003 fortalecendo elos entre as vivencias e os saberes, tessituras reconstrutivas da significação de suas experiências.
INFLUENCE OF THE HYPOXIA-INDUCIBLE FACTOR GENE ON THE COURSE OF ANTHRACYCLINE-INDUCED CHRONIC HEART FAILURE
Authors:   Novosibirsk State Medical University, Novosibirsk, Russia, Shilov S.N. , Berezikova E.N. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Bobyleva E.T. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Pinkhasov B.B. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Popova A.A. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Slesareva A.M. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Zakharova E.S. ,   Novosibirsk State Medical University, Novosibirsk, Russia
Published: December 2023

Relevance. Chronic heart failure (CHF) is a serious complication in the treatment of tumor diseases due to the cardiotoxic effect of anticancer drugs, especially anthracyclines. Despite an ever-increasing understanding of the molecular basis of anthracycline-induced cardiotoxicity, the precise mechanisms of action remain unknown, limiting the ability to effectively prevent this complication of polychemotherapy (PCT). Aim. To evaluate the effect of polymorphism (rs11549465) of the hypoxia-inducible factor subunit 1 alpha (HIF1α) gene on the course of anthracycline-induced CHF. Materials and methods. The study included 114 women with CHF that developed 12 months after the end of breast cancer chemotherapy using anthracycline drugs. All patients received therapy with carvedilol and enalapril. The control group (n = 70) consisted of women who received doxorubicin as part of chemotherapy, but they did not develop CHF 12 months after completion of PCT. The HIF1α gene polymorphism (rs11549465) was assessed using polymerase chain reaction. The course of CHF was monitored at baseline, after 12 and 24 months. Results. No significant differences were found in the frequencies of the studied polymorphism of the HIF1α gene in the groups of patients with CHF and the control group. Consequently, HIF1α gene polymorphisms are not associated with an increased risk of developing cardiac dysfunction after tumor therapy with anthracycline antibiotics. However, it was found that in women with progression of CHF after chemotherapy with anthracyclines, the frequency of occurrence of the CT genotype was statistically significantly higher than that in the group of women without progression of this pathology after 24 months of prospective observation (68.5 and 23.3%, respectively, p = 0.009). Consequently, the presence of the CT genotype of the HIF1α gene (rs11549465) (OR = 2.93; p = 0.009) is associated with an unfavorable course of CHF after anthracycline chemotherapy. Conclusion. The results obtained may indicate a genetically determined predisposition to the progression of anthracycline-induced CHF. The presence of the CT genotype of the HIF1α gene (rs11549465) is associated with an unfavorable course of CHF after anthracycline chemotherapy, which can be realized through changes in the activity of HIF1α and, accordingly, the sensitivity of cardiomyocytes to hypoxia.
SIGNS OF PROFESSIONAL STRESS IN THE SECOND YEAR CLINICAL RESIDENTS OF OTHRINOLARINGOLYNGOLOGY TRAINING
Authors:   Novosibirsk State Medical University, Novosibirsk, Russia, Poteryaeva E.L. , Ushakova K.Yu. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Fedorova L.T. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Chaukina V.A. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Kiselev A.B. ,   Novosibirsk State Medical University, Novosibirsk, Russia
Published: December 2023

Aim: using a survey with standardized questionnaires for professional emotional burnout to identify emotional signs of professional stress among the second year clinical residents of otorhinolaryngology training. Materials and methods. Standard questionnaires “Professional burnout for medical workers” and 4DDAS (depression, depersonalization, anxiety, somatization) were used. 20 clinical residents studying in the otorhinolaryngology department of the City Clinical Hospital No. 1 simultaneously took part in the survey. Results. Emotional exhaustion in women was determined at an average level of 21.89 ± 0.34 points, in men at a low level of 14.96 ± 0.43 points (hereinafter p < 0.05). The level of depersonalization in women is also significantly higher than in men and is determined at a very high level – 14.26 ± 0.44 points, while in men it is at an average level – 9.88 ± 0.34 points. Women perceive professional success at an average level of 31.07 ± 0.24 points, and men at a high level of 27.64 ± 0.24 points. Conclusions. It has been shown that training in the professional activities of an otorhinolaryngologist in an inpatient setting of a multidisciplinary hospital affects clinical residents as chronic professional stress of moderate intensity, which is accompanied by a moderately increased level of somatization. Women are more in need of prevention of professional stress than men, due to more significant emotional exhaustion and depersonalization. In order to develop emotional resistance to professional stress factors, clinical residents are recommended to take conscious, regular care of their health and take active part in the life of the professional community of otorhinolaryngologists.
APPLICATION OF THE INTRAOPERATIVE METHOD FOR ASSESSING INTESTINAL ANASTOMOTIC DEHISCENCE ON ANIMAL MODEL
Authors:   Novosibirsk State Medical University, Novosibirsk, Russia, Glazkov А.А. , Kuznetsov А.V. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Aleksandrova V.V. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Tyugaeva S.S. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Rozhkov N.S. ,   Novosibirsk State Medical University, Novosibirsk, Russia
Published: December 2023

Studies of on intestinal anastomoses have been carried out for many years, both clinical and experimental. However, it is quite difficult to correlate experimental studies with clinical ones since the criteria assessed are often different, and the conclusions made in experimental studies are not always relevant in clinical practice. In addition, a low-traumatic method for intraoperative assessment of the dehiscence of the intestinal anastomosis that has precise numerical criteria has not yet been developed. In this connection, the search for such a method is a highly topical direction. The aim of this research is to develop and study a method of intraoperative assessment of the intestinal anastomosis integrity on an animal model. The study was performed on the cecum of a brush rabbit (Sylvilagus bachmani) in vivo. 52 anastomoses were performed. The integrity assessment was made using the hydrotest method accor¬ding to the author's technique (patent for invention No. 2785493). The essence of the technique is to insert directly through the suture line a Foley catheter connected to a system generating a hydrostatic pressure of 50 mm Hg. If significant leakage was detected, the defect was sutured using interrupted method. On the seventh day after the primary surgery, a diagnostic relaparotomy was performed to assess postoperative complications. The study determined that the method of intraoperative integrity assessment makes it possible to detect anastomotic defects and prevent anastomotic leakage.
Pharmacokinetics of the bradykinin antagonist derivative 1,4-benzodiazepin-2-one in the experiment
Authors:   Siberian State Medical University, Aliforenko A.E. ,   Innovative Pharmacological Research LLC (Ifar, LLC), Tomsk, Russia, Bykov V.V. ,   Siberian State Medical University; Innovative Pharmacological Research LLC (Ifar, LLC), Tomsk, Russia, Bykova А.V. ,   Innovative Pharmacological Research LLC (Ifar, LLC), Tomsk, Russia, Motov V.S. ,   Innovative Pharmacological Research LLC (Ifar, LLC), Tomsk, Russia, Kozhukhovskiy K.Е. ,   Innovative Pharmacological Research LLC (Ifar, LLC), Tomsk, Russia, Pavlovskiy V.I. ,   Innovative Pharmacological Research LLC (Ifar, LLC), Tomsk, Russia, Khazanov V.A. ,   Innovative Pharmacological Research LLC (Ifar, LLC), Tomsk, Russia, Vengerovskii A.I. ,   Siberian State Medical University, Tomsk, Russia
Published: December 2023

Introduction. The 1,4-benzodiazepin-2-one derivative (codenamed – PAV-0056), in a wide range of low doses 0.1–10 mg/kg has a pronounced analgesic effect as bradykinin receptor type 1 antagonist. Preclinical study of the pharmacokinetics of a new potential analgesic with different routes of administration in appropriate doses seems to be relevant. Aim. To evaluate the pharmacokinetic parameters, bioavailability and transmembrane transport of the 1,4-benzodiazepin-2-one derivative PAV-0056. Materials and methods. PAV-0056 at doses of 0.1, 1 and 10 mg/kg was administered in a 1% aqueous solution of polyvinylpyrrolidone into the stomach and vein of male Sprague Dawley rats (age 1.5–3 months) weighing 250–300 g. We determined the plasma concentration of PAV-0056 in the blood of rats at discrete time intervals using mass spectrometry. The pharmacokinetic parameters and absolute bioavailability of PAV-0056 were studied. The permeability of PAV-0056 through a cell monolayer was studied on a 21-day cell culture originated from of colorectal carcinoma (CaCO-2). Results. The absolute bioavailability of the 1,4-benzodiazepin-2-one derivative PAV-0056 after administration into the stomach of rats at a dose of 0.1 mg/kg is 10.1 ± 6.1%, at a dose of 1 mg/kg – 2.2 ± 0.1%, at a dose of 10 mg/kg – 6.4 ± 0.8%. Systemic exposure AUC and maximum plasma concentration Cmax change linearly with increasing dose of PAV-0056 from 0.1 to 10 mg/kg (coefficients of determination R2 are 0.9767 and 0.9976, respectively). PAV-0056 is absorbed from the small intestine within 1 h and eliminated from plasma within 5 h (the lower limit of quantification of PAV-0056 in plasma is 0.1 ng/ml). After intravenous administration, PAV-0056 is eliminated within 0.5 h. The analgesic has a total clearance (ClT) of 83.16 l/kg/h and is not a P-glycoprotein substrate. Conclusion. The lipophilic derivative of 1,4-benzodiazepin-2-one, PAV-0056 after administration into the stomach is absorbed from the small intestine by passive diffusion with a bioavailability of no more than 10.1 ± 6.1%. Linear pharmacokinetics and no interaction with P-glycoprotein allow PAV-0056 to be positioned as a non-opioid analgesic with a good safety profile.