bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrated Network Monitoring using Zabbix with Push Notification via Telegram
Authors: Mohd Fuzi Mohd Faris , Mohammad Ashraf Nur Fatin , Jamaluddin Muhammad Nabil Fikri
Published: April 2022

The world is becoming increasingly dependent on online services. To offer a service, a network must be in good health and free of any attacks. An attack happens when the confidentiality, integrity, or availability of a service is compromised. Network monitoring is a solution capable of maintaining these network devices from their usage up to detecting attacks. A denial of service (DoS) attack on a network can affect the network performance and can cause serious damage. Zabbix is an open-source network monitoring tool that is versatile and can be used to monitor hosts on a network. The purpose of this project is to detect possible ping and SYN flooding attempts on a server and send alerts to the administrator via Telegram. This project uses Zabbix to monitor a server for potential ping and SYN flooding attacks. Tcpdump is used to log the pings received by the server. When the server continuously receives 10 or more pings per second, an alert will be automatically generated and sent to the administrator via Telegram. Similarly, a SYN flood attack is detected by using netstat’s SYN_RECV flags. When the server continuously receives more than 10 SYN packets without an ACK packet, Zabbix will generate alerts that are sent via Telegram and update the dashboard to show a problem. Zabbix was able to accurately detect all ping flooding attempts on the server. However, SYN flooding attacks were not as accurately detected. The use of Zabbix can be implemented in small businesses or networks for an automated monitoring system. Future work can include more DDoS attacks and adding countermeasure actions when detecting attacks by blocking the IP or port associated with the attack. SYN flooding detection needs to be improved because only two out of three attacks were able to be caught.
Digital infrastructure and economic growth—Evidence for China
Authors: ZHOU An
Published: April 2022

China’s economic structure has made subtle changes with the development of digital economy. Along with the marginal diminishing effect of Chinese monetary policies and the increase of the overall leverage ratio, the Chinese economic growth mode of relying on real estate, trade and infrastructure construction in the past will not be sustainable in the next decade. This paper makes a theoretical analysis on the reduction of the search cost in digital economy. Also, this paper used empirical methods to study the relationship between China’s economic growth and digital infrastructure construction. In conclusion, the digital economy has reduced the search cost for people, and big data will become a product factor participating in labor distribution. In addition, this paper proposes for the first time that digital economy can effectively restrain inflation. The Chinese government needs to attach importance to the issue that current internet enterprise oligarchs will probably monopolize the usage of big data in the development of digital economy in the future and become the obstacle to effective economic growth. In addition, close attention should be paid to the vulnerabilities of financial and taxation systems for digital economic entities to avoid continuous disguised tax subsidies to internet oligarchs, thus preventing industrial monopoly.
Expression of DNA-damage response and repair genes after exposure to DNA-damaging agents in isogenic head and neck cells with altered radiosensitivity
Authors: Todorovic Vesna , Groselj Blaz , Cemazar Maja , Prevc Ajda , Zakelj Martina Niksic , Strojan Primoz , Sersa Gregor
Published: April 2022

Background

Increased radioresistance due to previous irradiation or radiosensitivity due to human papilloma virus (HPV) infection can be observed in head and neck squamous cell carcinoma (HNSCC). The DNA-damage response of cells after exposure to DNA-damaging agents plays a crucial role in determining the fate of exposed cells. Tightly regulated and interconnected signaling networks are activated to detect, signal the presence of and repair the DNA damage. Novel therapies targeting the DNA-damage response are emerging; however, an improved understanding of the complex signaling networks involved in tumor radioresistance and radiosensitivity is needed.

Materials and methods

In this study, we exposed isogenic human HNSCC cell lines with altered radiosensitivity to DNA-damaging agents: radiation, cisplatin and bleomycin. We investigated transcriptional alterations in the DNA-damage response by using a pathway-focused panel and reverse-transcription quantitative PCR.

Results

In general, the isogenic cell lines with altered radiosensitivity significantly differed from one another in the expression of genes involved in the DNA-damage response. The radiosensitive (HPV-positive) cells showed overall decreases in the expression levels of the studied genes. In parental cells, upregulation of DNA-damage signaling and repair genes was observed following exposure to DNA-damaging agents, especially radiation. In contrast, radioresistant cells exhibited a distinct pattern of gene downregulation after exposure to cisplatin, whereas the levels in parental cells were unchanged. Exposure of radioresistant cells to bleomycin did not significantly affect the expression of DNA-damage signaling and repair genes.

Conclusions

Our analysis identified several possible targets: NBN, XRCC3, ATR, GADD45A and XPA. These putative targets should be studied and potentially exploited for sensibilization to ionizing radiation and/or cisplatin in HNSCC. The use of predesigned panels of DNA-damage signaling and repair genes proved to offer a convenient and quick approach to identify possible therapeutic targets.
Hypertensive Crisis in Patients with Acute Intermittent Porphyria
Authors: Andrejic Olivera , Vucic Rada , Cupic Violeta Iric , Davidovic Goran
Published: April 2022

Introduction: Acute intermittent porphyria (AIP) is the most common and the most severe form of acute hepatic porphyria.

Case report: Patient, 39 years old, was admitted to the Emergency Department because of abdominal pain. Abdominal pain started 5 days before the admission. The diagnostic research in his hospital showed presence of a stone in the right kidney, and the patient was transported to the other Clinical Centre, where a common urine test showed: high values of delta - aminolevulinic acid and porphobilinogen. The patient was transported to our Clinical Centre. At the admission, abdominal pain decreased, but the patient had a hypertensive crisis with a headache, tearing eyes, swelling, anxiety.Common laboratory tests were in reference range, except creatinine, CRP, arterial blood gas analysis, urine test. The hypertensive crisis was treated by beta blockers and diuretics in maximal doses, but without a positive effect, so we decided to try with Glyceryl trinitrate intravenously. Control blood pressure was 170/100mmHg….130/80mmHg.

Discussion: Porphyria can be a diagnostic problem, because one of the manifestations can be abdominal pain.

Conclusions: Comorbidities can be critical in the therapy of life threating conditions.
Assessment of the Systemic Oxidative Stress in Preeclampsia
Authors: Bînă Anca M. , Anechitei Andreea I. , Lelcu Theia , Lința Adina V. , Chiriac Daniela V. , Mocanu Adelina G. , Bernad Elena , Popa Zoran L. , Craina Marius L. , Muntean Danina M. , Borza Claudia , Crețu Octavian M.
Published: April 2022

Preeclampsia (PE) is a major complication of pregnancy with both mother and fetal adverse outcomes. Pregnancy is a state of increased oxidative stress that has been reported to be exacerbated when complicated with preeclampsia. However, conflicting data are available in literature regarding the systemic oxidative stress in PE pregnancies. The present pilot study was purported to assess systemic oxidative stress in preeclamptic vs healthy pregnancies. To this aim plasma derived compounds of reactive oxygen metabolites (d-ROMs) and the biological antioxidant potential (BAP) were determined in mild and severe preeclamptic pregnancies using the Diacron equipment. Both healthy and preeclamptic pregnancies showed high levels of systemic oxidative stress. Paradoxically, significantly higher values of d-ROMs were found in healthy pregnancies as compared to the PE ones. At variance, in preeclamptic pregnancies, a major increase in the plasma antioxidant capacity occurred. In this pilot study, we report an increase in the systemic antioxidant capacity in preeclamptic pregnancies.
Closing the Gap
Authors: Toregas Costis , Heller Rachelle , Walsh Taly , Balut Calese
Published: April 2022

This paper describes the activities and results of a George Washington University DoD Cyber Scholarship Program (CySP) capacity building project Grant No. H98230-19-1-0320 during the 2020-2021 academic year. In particular, the report provides information about the conference held on “Closing the Gap: Re-entry of Women Veterans into Cybersecurity Careers.”

Closing the Gap was a working virtual conference combining presentations and break-out discussions which focused on the research in cyber workforce development and gender issues. By bringing together a variety of stakeholders in this topic, this working conference was able to address how to overcome challenges to increase the recruitment, representation, and retention of women veterans in the cybersecurity workforce and to provide practical suggestions for improvement.
Władca Lewawu w lekturze ekokrytycznej
Authors:   Uniwersytet Pedagogiczny w Krakowie, Chrobak Małgorzata
Published: April 2022

Lord of the Lewaw [Władca Lewawu] in ecocritical reading Last year marked the 30th anniversary of the ‘actual debut’ of Dorota Terakowska in fantasy prose. According to Jolanta Ługowska, who wrote an excellent work devoted to the output of this great Cracow writer, Lord of the Lewaw [Władca Lewawu] is ‘a story about power and its mechanisms’. To put it more precisely, the story of Bartek-Ketrab was written during the period of Martial Law, but the publication was blocked for political reasons. Since its premiere in 1989, the work has been one of the required reading books, it attracts the attention of critics and is popular among readers. Its long-lasting presence in the circle of literary selection, encourages readers to reach for it again and reinterpret it using the latest tools of literary exploration, which is represented, for instance, by ecological humanities or ecocriticism. Such an approach is stimulated by certain ‘ecotraces’, which may be distinguished in Terakowska’s work. These include: the threat of an ecological disaster hanging over Cracow due to air pollution and the contamination of the Vistula River, a layer of dust and dirt, which destroys the historical buildings in the city, as well as an illusory ‘ecological paradise’, as Wokark is at first perceived by the hero. Also, providing the protagonist of Lord of the Lewaw with the awareness of negative environmental changes, as well as the process of emerging from the ennvironmental crisis, which is included in the novel, seem close to ecocritical literature.
Kobiecość i męskość w twórczości Doroty Terakowskiej
Authors:   Akademia Pomorska w Słupsku, Lasoń-Kochańska Grażyna
Published: April 2022

Femininity and masculinity in the work of Dorota Terakowska In Dorota Terakowska’s work, the characters are often named Adam and Ewa, which is a sign of the universalization of male and female experiences. In the books Where the angels fall down [Tam, gdzie spadają anioły], In Cat`s Land [W krainie Kota] and It [Ono], no sex seems to be privileged. In the novel Pupa [Poczwarka], the narrator identifies with women and their system of values. In works based on mythical models of initiation, like Lord of the Lewaw [Władca Lewawu] and Witches’ daughter [Córka Czarownic], gender stereotypes are visible. While the characters of these books – a boy and a girl – enter adult life, they repeat the cultural expectations related to masculinity and femininity. Terakowska’s next book, Mirror of Mr. Gryms [Lustro Pana Grymsa], goes back to old matriarchal sources related to female initiation.
Terakowska zaangażowana
Authors:   Uniwersytet Śląski w Katowicach, Wójcik-Dudek Małgorzata
Published: April 2022

Terakowska involved This article is an attempt to describe the place of journalistic texts in the context of the phenomenology of the journalistic activity of Dorota Terakowska. The author of the article refers to columns and reports from the volumes Dress rehearsal [Próba generalna], A person is a good address [Dobry adres to człowiek] or the autobiographical works The chewing gum [Guma do żucia] and presents the writer’s achievements as a manifestation of care for the shape of the place of residence, and thus the relationship with another human being. Microanalysis of Terakowska’s private spaces and the memories of her daughters about the writer’s apartments and ways of arranging them, as well as the characteristics of the writer’s attitude towards the institution of the house, allow for the reconstruction of the idea of living presented by the author of Lord of the Lewaw [Władca Lewawu], thus making the reader familiar with her commitment to building a community.
La gestión de los residuos municipales al amparo del nuevo modelo de economía circular. A propósito del Proyecto de Ley de Residuos y Suelos Contaminados
Authors: Martínez Navarro Juan Alejandro
Published: April 2022

Las intervenciones y acciones medioambientales, consecuencia principalmente de la creciente repercusión de fenómenos como el cambio climático, están ocasionando un pausado pero constante e imparable procesotransformador de carácter social, económico y jurídico, entre otros. Su incidencia repercute en innumerables ámbitos y, en concreto, en la gestión de residuos los efectos jurídicos son de acuciante actualidad. Así pues,en el presente trabajo se analizará la reciente legislación (Ley 7/2021, de 20 de mayo, de Cambio Climático y Transición Energética y Proyecto de Ley de Residuos y Suelos Contaminados para una Economía Circular) y los efectos que, al amparo de la economía circular, se prevén sobre la gestión de residuos municipales.
Derecho a la ciudad, obras públicas locales y participación ciudadana
Authors: Entrena Ruiz Daniel Bruno
Published: April 2022

Tras exponer la vinculación entre interés público, participación democrática y el Derecho a la ciudad, el trabajo analiza si el régimen jurídico establecido para el diseño y ejecución de las obras públicas en el ámbito local garantiza la participación de los ciudadanos. A tal fin, se disecciona en primer lugar, conforme a su régimen legal, los distintos tipos de obras existentes. Posteriormente se exponen los impedimentos que, en relación con la participación pública, contiene el régimen de las llamadas obras públicas ordinariaslocales; finalmente, se desciende hasta un concreto ejemplo de reglamentación local para  evidenciar que –en ausencia de un régimen general– dicha participación tiende a garantizarse cuando se aproxima al régimen de obras urbanísticas. El trabajo concluye exponiendo el caso de la Ley catalana de obra pública, que garantiza la participación pública a todos los ciudadanos en el procedimiento de licitación pública no solo de las obras autonómicas sino también locales.
La controvertida interpretación y aplicación del artículo 26.2 de la Ley de Bases de Régimen Local
Authors: Franco Jiménez Teresa , Zafra Víctor Manuel
Published: April 2022

La ciudadanía se siente poco afectada por los conflictos de competencia, pero sí por la descoordinación entre diferentes administraciones públicas. A propósito de hechos reales se analiza la controvertida interpretación y aplicación del artículo 26.2 LBRL que prescribe la coordinación por la Diputación de una serie de servicios para los municipios con población inferior a 20.00 habitantes, uno de ellos, el acceso al núcleo de población donde unos vecinos sufren accidentes de tráfico y reclaman la correspondiente indemnización. ¿Cuál es la instancia pasivamente legitimada? ¿El municipio que debe prestar su conformidad al plan propuesto por la Diputación o la Diputación que debe proponerlo?
Cambio climático y derechos fundamentales diacrónicos: la Sentencia alemana del Cambio climático y su doctrina
Authors: Ruiz Prieto Mario
Published: April 2022

La finalidad del artículo es comentar la sentencia sobre el cambio climático del Tribunal Constitucional Alemán y la doctrina novedosa sobre las obligaciones de protección que plantea en relación con las obligaciones de protección de los derechos fundamentales. Al hilo de la defensa de los derechos de las generaciones futuras, el Tribunal realiza una interpretación intertemporal o diacrónica de los derechos fundamentales que lleva a la declaración de inconstitucionalidad parcial de la Ley de Cambio Climático alemana. Esta proyección a futuro de los derechos fundamentales, especialmente relevante para un problema como el cambio climático, será analizada como un subtipo del esquema clásico de las relaciones jurídicas multipolares, aplicable a la hora de juzgar las obligaciones iusfundamentales de protección u obligaciones positivas del Estado. Por último, se señala la importancia de dichas obligaciones para la doctrina española a la hora de afrontar problemas como la pandemia COVID o la legislación española sobre el cambio climático.
Yoğun Bakım Kliniklerinde Yatan Hastalarda Hemoglobin ve Albümin Değerlerinin Basınç Yarası Gelişimine Etkisi
Authors: EFTELİ Elçin
Published: April 2022

Bası yaraları tüm dünyada bakımın yetersizliğinin bir göstergesi olarak kabul edilmektedir. Ayrıca hastanede yatış süresini uzatmakta ve mortalite ve morbitide oranlarını da arttırmaktadır. Çalışmamızda hemoglobin ve albümün değerlerini basınç yarası gelişimi üzerine olan etkisi incelenmiştir. Tanımlayıcı tipte olan araştırmanın örneklemini Kasım 2021 – Mart 2022 tarihleri arasında yoğun bakım kliniklerinde yatan 18 yaş üzeri 68 yetişkin birey oluşturdu. Çalışma kapsamına alınan hastaların yaş ortalamalarının 67.08±14.35, %42.6’sının kadın, %17.6’sının entübe, %57.4’ünün normal bilinç düzeyine sahip olduğu belirlendi. Hastalarda basınç yarası gelişme oranı %26.5’dir. Çalışmamızda yoğun bakım kliniklerinde yatan, bası yarası gelişen hastalarda hemoglobin ve albümin değerlerinin bası yarası gelişmeyen hastalara göre daha düşük olduğu ve farkın istatistiksel olarak anlamlı olduğu belirlenmiştir.
Pemodelan Jumlah Kematian Bayi di Kota Bandung dengan Menggunakan Regresi Zero-Inflated Poisson
Authors: Dwi Putri Amalia , DEVIANTO DODI , YANUAR FERRA
Published: April 2022

Kematian bayi merupakan salah satu indikator dalam menentukan tingkatkesehatan masyarakat. Salah satu upaya untuk mengurangi jumlah kematian bayi adalah dengan mengkaji faktor - faktor penyebabnya. Banyaknya kasus kematian bayi yang berupa data diskrit dan faktor - faktor yang mempengaruhinya dapat dimodelkan menggunakan regresi Poisson. Namun, dalam analisis regresi Poisson sering ditemukan kondisi overdispersi yakni nilai varians dari variabel respon lebih besar dari nilai mean. Overdispersi dapat terjadi karena terlalu banyaknya nilai nol (excess zeros) pada variabel respon.Model regresi Zero-In ated Poisson merupakan salah satu metode yang dapat mengatasi masalah overdispersi. Pada penelitian ini, data kasus jumlah kematian bayi memiliki terlalu banyak nilai nol, sehingga regresi Zero-Inflated Poisson lebih tepat digunakan untuk memodelkan jumlah kematian bayi dan faktor - faktor yang mempengaruhinya di Kota Bandung Tahun 2019. Hasil analisis menunjukkan bahwa faktor - faktor yang berpengaruh secara signifikan terhadap kasus jumlah kematian bayi adalah persentase berat badan bayi lahir rendah (BBLR), persentase kunjungan neonatal selama 3x dan persentase bayi yang diberikan ASI eksklusif.
El tema del alba en la poesía de Mariluz Escribano
Authors: Gahete Jurado Manuel
Published: April 2022

La poesía de Mariluz Escribano Pueo parte de la tradición más noble tanto en el fondo como en la forma. Avezada al dolor por el aciago avatar de su infancia, la soledad y el silencio han sido inseparables y fieles compañeros de andadura. Con una señera motivación humana, reflejada en toda su producción periodística y literaria, Escribano nos acerca a la experiencia amorosa desde el desarraigo. Forjada en la lectura, la educación será resorte eficaz y fundamento imprescindible de su posicionamiento ante el mundo. Partiendo de una metodología deductiva, que se sustenta en la herencia románica, se conforma un vínculo activo entre el statu quo de la realidad y la distorsión sustancial del acto creador, aportando la confrontación efectiva de un modelo que asume la tradición como ejercicio de reconocimiento y nos conduce a recobrar para el canon la palabra silenciada de una mujer luchadora y valiente enfrentada al rigor de su destino.
La lectura de los textos poéticos en la clase de lengua: imaginación, competencia metafórica, digitalización, poesía juvenil y voces olvidadas
Authors: Cabrera Romero Lucía , Foncubierta José Manuel
Published: April 2022

Este artículo presenta la necesidad de incorporar en las aulas la poesía como herramienta para el desarrollo de la competencia comunicativa del alumnado, sea de español lengua materna o lengua extranjera. Como fundamentación teórica, se plantea el desarrollo de conceptos como el de competencia metafórica antes que otros marcos de acción, que ya estaban presentes en las aulas y que justificaban la inclusión de la poesía en la clase de lengua; este es el caso de la competencia literaria. La provisión de una nueva visión sobre la didáctica de la lengua a través de la poesía ofrece también la oportunidad de proponer la inclusión de nuevas voces (poesía joven) o no tan nuevas (poetas olvidadas), porque la poesía también contiene voces alejadas del canon literario tradicional. Además de una fundamentación teórica y de la provisión de nuevos recursos, el artículo aborda, finalmente, la importancia de Internet y de los contenidos digitales para aproximar al alumnado hacia propuestas poéticas enriquecidas desde un plano multimodal o multisensorial.
Evaluación del impacto del perfil del alumnado y su formación preuniversitaria en la asignatura de Química del primer curso de grado en tres facultades de ciencias de la UCM
Authors:   Universidad Complutense de Madrid, Cuervo Rodríguez María Rocío , García Fresnadillo David ,   Universidad Complutense de Madrid, Moreno Jiménez Florencio ,   Universidad Complutense de Madrid, Ramírez Castellanos Julio ,   Universidad Complutense de Madrid
Published: April 2022

En este trabajo se analizan y comparan las características del perfil de los estudiantes de nuevo acceso en las titulaciones de Química, Biología y Óptica-Optometría, en tres facultades de Ciencias de la Universidad Complutense de Madrid (UCM). Se examina el rendimiento aca-démico del alumnado en la materia básica de Química, así como su relación con la situación de partida o perfil del alumnado que ingresa en la Universidad. Asimismo, se han detectado las carencias que presentan los estudiantes de primer curso de Grado en dicha materia, a partir de la autoevaluación del grado de conocimiento del temario preuniversitario de la asignatura de Química. Los resultados señalan que el alumnado mayoritariamente ha cursado la asignatura de Química, destacando que habría elegido otro Grado si hubiese obtenido la nota de acceso necesaria. Además, los estudiantes manifiestan menor conocimiento en temas que, en general, se imparten específicamente en el segundo curso de Bachillerato.
Competencia digital en educación superior
Authors:   Universidad de Granada, Ibáñez Cubillas Pilar
Published: April 2022

La competencia digital es básica en todas las materias y en todos los niveles de educación superior. Este trabajo presenta un análisis del perfil de los estudiantes de educación superior en materia de competencia digital. La muestra se compone de 89 estudiantes con edades comprendidas entre los 19 y los 21 años. Se emplea una metodología cualitativa basada en el estudio de caso, y la recogida de datos se realiza a través de la plataforma de autodiagnóstico de competencias digitales de la Junta de Andalucía, basada en el denominado DigComp. Los resultados revelan que los estudiantes universitarios tienen un «nivel previo» en competencia digital, tanto hombres como mujeres; sin embargo, el nivel inicial se manifiesta con valores más elevados en hombres que en mujeres. Como conclusión se reflexiona sobre el bajo nivel de competencia digital en nativos digitales.
An Overview of the Status of Spiritual Care in Nursing Education in Iran and the World
Authors: Ahmadi Mehrnaz , Sedighie Ladan , Shirozhan Shima , Salimi Atefe , Rassouli Maryam
Published: April 2022

Spirituality is an essential component of health. However, evidence suggests that patients’ spiritual dimension has received less attention, possibly due to the unpreparedness of nurses to provide spiritual care. This study aimed to investigate the context of spiritual care in nursing education and to review the necessary preparations to provide spiritual care, as well as to examine the effective models and methods of spiritual care education in nursing. A comprehensive and in-depth review of the texts was conducted using national and international databases including SID, Magiran, Barakat, PubMed, ProQuest, Scopus, Embase, Web of Science and Google Scholar, spanning the years 2016–2021 and using the keywords “Spiritual care”; “Spiritual Curriculum”; “Spirituality”; “Religion”; “Nursing curriculum”; “Nursing students”; “Nursing educator”; “Nursing education”; “Education”; “Nursing”; and “Curriculum.” Out of 743 obtained articles, 39 were enrolled. The results showed that the basis of spiritual care in nursing education is inappropriate and the necessary preparations for providing proper spiritual care are not well provided. Although various models and variants have been presented to educate spiritual care, they are not organised throughout the students’ curriculum. Using a curriculum includes spirituality, spiritual awareness, and spiritual care, as well as organising it throughout the student curriculum, which can be the first step in providing decent spiritual care. Therefore, it is worthwhile to take effective steps in promoting spiritual care by solving the existing challenges and reducing the gap between theoretical and clinical education.
Theoretical analysis of expansion process of wet water vapor in working chamber of piston long-stroke linear drive of compressor unit
Authors:   Omsk State Technical University, Kapelyukhovskaya A. A. , Chernov G. I. ,   Omsk State Technical University, Gromov A. Yu. ,   Omsk State Technical University, Kalashnikov A. M. ,   Omsk State Technical University, Karagusov V. I. ,   Omsk State Technical University, Paramonov A. M. ,   Omsk State Technical University
Published: April 2022

In this paper, the process of expansion of wet water vapor in a piston long-stroke low-speed drive of a low-flow compressor unit is considered. The study is carried out on the basis of the developed mathematical model, which includes both the basic thermodynamic equations and the equations describing the process of heat exchange of the working substance with the walls of the working chamber during the expansion process. The results of the calculations carried out reflect the dependences of pressure, temperature and degree of dryness on changes in the volume of the working cavity at various values of the initial degree of dryness in the process of expansion and the duration of the process. An analysis of the results obtained shows that an increase in the cycle time and a decrease in the initial degree of dryness lead to an intensification of the process of condensation of wet steam in the process of expansion and the possibility of obtaining complete condensation of the working fluid.
Study of carbon-free radiation life support system in spring and autumn periods
Authors:   Omsk State Technical University, Karagusov V. I.
Published: April 2022

Solar energy refers to renewable carbon-free energy. Experimental studies conducted in the springautumn periods of 2018–2021. In the conditions of the sharply continental climate of Western Siberia allowed us to draw a number of conclusions about the applicability of the radiation life support system for cottages, rural houses and other detached buildings. During the research, a large number of experimental temperature measurements are carried out with their recording in the memory of the logger 88598. The temperatures are recorded on the measuring cell of the experimental stand. The obtained experimental data are processed. In spring and autumn, it is more rational to replace radiation conditioning with ventilation, since at night the temperature difference between the radiation panel and the surrounding air is small.
Cellular tornadoes and how they shape our organs
Authors: Ravichandran Yamini
Published: April 2022

During development our organs take different distinct shapes. Researchers from the labs of Prof. Roux and Prof. Kruse at UNIGE show how under certain circumstances muscle cells collectively spiral and rotate to protrude and self-organize in 3D forming cellular tornadoes.
The Ocean 100: the big fishes of the blue economy
Authors: Virdin John
Published: April 2022

Growing economic use of the oceans may help determine the achievement of global conservation goals. In looking to see where this capacity rests, we find that the 10 largest companies in 8 core ocean-based industries generate, on average, 45% of each industry’s total revenues. This level of concentration presents both risks and opportunities to sustainability.
Diving into the icy origins of Martian valleys
Authors: Grau Galofre Anna
Published: April 2022

Mars is nowadays a frozen desert devoid of liquid water, but it was not always like this: giant valleys and canyons on its surface show that at some point in the remote past, water existed on the Martian surface. Trying to understand the origin of these valleys, we found answers in an unexpected place:  the plumbing system of ice sheets.
Structure and Magnetism of Iron- and Chromium-Intercalated Niobium and Tantalum Disulfides
Authors: Xie Lilia S. , Husremovic Samra , Gonzalez Oscar , Craig Isaac M. , Bediako D. Kwabena
Published: April 2022

Transition metal dichalcogenides (TMDs) intercalated with spin-bearing transition metal centers are a diverse class of magnetic materials where the spin density and ordering behavior can be varied by the choice of host lattice, intercalant identity, level of intercalation, and intercalant disorder. Each of these degrees of freedom alters the interplay between several key magnetic interactions to produce disparate collective electronic and magnetic phases. The array of magnetic and electronic behavior typified by these systems renders them distinctive platforms for realizing tunable magnetism in solid-state materials and promising candidates for spin-based electronic devices. This Perspective provides an overview of the rich magnetism displayed by transition metal-intercalated TMDs by considering Fe- and Cr-intercalated NbS2 and TaS2. These four exemplars of this large family of materials exhibit a wide range of magnetic properties, including sharp switching of magnetic states, current-driven magnetic switching, and chiral spin textures. An understanding of the fundamental origins of the resultant magnetic/electronic phases in these materials is discussed in the context of composition, bonding, electronic structure, and magnetic anisotropy in each case study.
Influence of Education Using Virtual Audiovisual Media on Pregnant Women's Knowledge About Covid 19 Prevention
Authors: Fakhriyah Fakhriyah , Bakhriansyah Mohammad , Noor Meitria Syahadatina , Putri Andini Octaviana
Published: April 2022

The emergence of coronavirus infections has resulted in an epidemic that is rapidly developing into one of the most significant public health threats in recent times. Maternal health services cannot be separated from being affected both in terms of access and quality. Pregnant women must be aware of the risk of contracting COVID-19 because have higher risk of the morbidity and mortality rates. The purpose of this study is to analyze the influence of online counseling on pregnant women's knowledge about COVID-19 prevention. This study used a quasi-experimental design with one group pretest-posttest design. The research location is in the Banjar Regency and Banjarbaru. The population is all pregnant women who visited the Poskesdes in Banjar Regency and the PMB in Banjarbaru as many as 66 people. Counseling is done online with audiovisual media. Samples was 46 people who were taken by purposive sampling. The independent variable is counseling about COVID-19 prevention and the dependent is knowledge. The method of data analysis is the Wilcoxon test. The intervention was carried out using google meet. Pre and post-tests were carried out to measure knowledge. The results of this study were that there was a significant difference in the knowledge of pregnant women before and after receiving counseling (df=46, p=0.0001). The conclusion of this study is counseling using audiovisuals can increase pregnant women’s knowledge about the prevention of COVID-19. Education about COVID-19 prevention can virtually be implemented in comprehensive maternal and child health services as an effort to prevent and control COVID-19.
Efeitos da suplementação com nutracêuticos sobre a calcificação de discos intervertebrais em cães da raça Dachshund
Authors: Tudury Eduardo Alberto , Baraúna Júnior Durval , Silva Ieverton Cleiton Correia , Trajano Sabrina Cândido , Bonelli Marília Albuquerque , Fernandes Thaiza Helena Tavares , Santos Cássia Regina Oliveira , Bezerra Juliana Karla , Rocha Nadyne Lorrayne Farias Cardoso , Costa Fabiano Séllos
Published: April 2022

O objetivo do presente estudo foi comparar o número de discos intervertebrais da coluna toracolombar mineralizados em cães jovens da raça Dachshund, que receberam ou não suplementação com sulfatos de condroitina, glicosaminoglicanos e manganês. Vinte filhotes de quatro meses de idade foram divididos em dois grupos de dez, sendo a seguir submetidos a dois protocolos de tratamento durante 240 dias. Grupo nutracêutico (GN) recebeu um tablete, ao dia, por via oral, contendo nutracêuticos e excipientes. Grupo controle (GC) recebeu um tablete, ao dia, por via oral, contendo os mesmos excipientes do GN. Imagens tomográficas foram obtidas nos momentos zero e após oito meses de tratamento. O percentual de animais classificados com mineralização foi mais elevado no GC quando comparados com GN (64,3% x 44,3%), diferença esta que para a margem de erro fixada (5%) se mostra significativa entre os grupos em relação à presença de mineralização (p < 0,05 risco relativo igual a 1,45 com intervalo que exclui o valor 1,00). No GN as maiores frequências de mineralização ocorreram no disco intervertebral T09-10 (70,0%), T11-12 e T13-L1 (50,0%) e, no GC, T09-10 (90,0%) e T10-11 (80,0%). Pode-se concluir que a administração da associação de manganês, sulfatos de condroitina e glicosamina, durante o primeiro ano de vida, em cães da raça Dachshund Miniatura, diminuiu o número de mineralizações discais na coluna toracolombar.
Community-aquired pneumonia associated with coronavirus disease (COVID-19): determination of pathological process progression predictors by clinical and hemocoagulation parameters
Authors: Pertseva T.O. , Bielosludtseva K.O. , Konopkina L.I. , Krykhtina M.A. , Myronenko O.V. , Botvinikova L.A. , Moiseienko O.F.
Published: April 2022

The search for clinical and laboratory markers of COVID-19-associated CAP progression is an urgent problem of today. The aim of our study was to determine the risk factors for the burden of the pathological process by establishing the diagnostic and prognostic significance of clinical and hemocoagulation parameters in the hospital stage of management of patients with CAP on the background of coronavirus disease (COVID-19). The study included 53 individuals of the main group. All patients were examined twice: on the first day of hospitalization (visit 1) and in the dynamics (7-10 days after hospitalization (visit 2)). In 30 (83.3%) patients of subgroup 1, despite adequate treatment, there was an increase in breathing rate and a decrease in saturation to severe (less than 92%) or critical (less than 85%) levels (in 28 and 2 cases respectively). In subgroup 2, the progression of respiratory failure to a critical level was observed in 5 of 12 (41.7%) patients. Conclusions: at the stage of hospitalization of patients with COVID-19-associated CAP the most sensitive clinical predictor of aggravation of the patient's condition is tachypnea of 20 or more; laboratory – the level of D-dimer 200 ng/ml, which increases the risk of progression of the pathological process by 16 times.
Psychological impact of COVID-19 pandemic on health care workers of tertiary care hospitals
Authors: Khan M.J. , Jamil B. , M.Z. Haroon
Published: April 2022

Healthcare workers (HCWs) are at increased risk of mental health issues when faced with the challenges associated with pandemics. This study was conducted to assess the psychological impact of pandemic on HCWs working in tertiary care hospitals of Khyber-Pakhtunkhwa province of Pakistan. This cross-sectional study was conducted between April & June 2020. By convenience sampling an electronic form of Goldberg General Health Questionnaire was distributed among HCWs of the private sector and public tertiary care hospitals. Data were analyzed using SPSS version 22. Inferential analysis was done. The significant level was considered at p=<0.05. Total of 186 HCWs among which 105 (56.5%) males and 81 (43.5%) females par­ticipated in the survey, a mean age of 37.6±9.28 years. The highest prevalence was found for social dysfunction 184 (97.8%) followed by somatization, 169 (92.8%). Significance of difference was found between age group and anxiety (p=0.018), specialty of HCWs with somatization and social dysfunction (p=0.041 and 0.037 respectively). Pandemic poses a significant risk for the mental health of HCWs. During pandemics at its peak, proper mental health support program, personal and family protection assurance is highly recommended for provision of quality care by HCWs.
Definition of the dependence of QTc interval prolongation on glycemic control in patients with type 2 diabetes mellitus
Authors: Pertseva N.O. , Moshenets K.I.
Published: April 2022

The aim of the study: to assess the impact of glycemic variability on the duration of QTc interval in patients with diabetes mellitus type 2. 68 patients with type 2 diabetes mellitus (DM) and glycosylated hemoglobin (HbA1c) level ≤10% were examined. Of them – 37 (54.4%) men and 31 (45.6%) women. The average age – 46.0 (43.0; 54.0) years, the duration of DM type 2 – 7.0 (5.0; 9.0) years. Patients were divided into 2 groups according to HbA1c level: group 1 (n=31) with HbA1c <7% and group 2 (n=37) with HbA1c ≥7%. The control group consisted of 10 practically healthy people, compared by gender and age. The duration of the QTc interval was calculated automatically by Bazett's formula during 24-hour Holter electrocardiogram (ECG) recordings. Additionally, the percentage of cases of exceeding the QTc threshold over 450 ms (QTc>450) was also calculated. Simultaneously with 24-hour Holter monitoring, the continuous glucose monitoring was performed, using iPro2 system (Medtronic MiniMed, USA). The maximum value of glycemia (Gmax), the minimum value of glycemia (Gmin), as well as indicators of glycemia variability (GV) were analyzed: standard deviation of mean glycemia (SD) and glycemia range (GR). The duration of daily QTc and the value of QTc >450 in patients with type 2 DM were significantly greater compared with the control group (p<0.05) and did not depend on the HbA1c level. In type 2 DM patients without recorded hypoglycemic episodes, the characteristics of QTc did not differ from the results of the control group (p>0.05). At the time of the hypoglycemic episode, the QTc duration in patients with type 2 DM significantly increased compared with the average daily value of QTc in the same patients – 487 (466; 519.5) ms against 436.5 (431; 452) ms (p<0.001). A strong correlation between QTc duration and the presence of hypoglycemia was determined (rs=0.78; p=0.023). QTc duration also correlated with GR (rs=0.23; p=0.016) and SD (rs=0.21; p=0.021). Therefore, it was found that in patients with type 2 diabetes, the prolongation of QTc duration is associated with high glycemic fluctuations and hypoglycemia (p<0.05) regardless of the HbA1c level.
Peculiarities of the differential diagnosis of different types of cerebral sinus and vein thrombosis in patients with ENT organs involvement
Authors: Lamza N.V. , Kovtunenko O.V. , Morgachova G.K. , Tereschenko L.A. , Lyschenko D.V. , Zaitsev A.V. , Fannan A.
Published: April 2022

The paper is devoted to the problems of diagnosis of septic and aseptic forms of central venous thrombosis. The aim of the study was to study the clinical manifestation and lesions of the ear, nose and throat, in patients with aseptic central venous thrombosis in order to increase the efficiency of differential diagnosis of various forms of thrombosis and to determine the tactics of further treatment of patients with this disease. Variants of manifestation of lesions of Lesions of the ear, nose and throat were studied in 14 patients with aseptic central venous thrombosis who were hospitalized for the period from 2016 to 2019, the results of their ophthalmological and neurological examination, as well as laboratory studies are given. It was found that among patients with cerebral venous thrombosis in most cases (82.4%) various changes in otolaryngological status were detected, of which 21.4% of cases – with septic lesions of the ENT organs, 78.6% of cases – with aseptic changes. During the examination, the character of these pathological changes in otolaryngology status in non-purulent lesions of the ENT organs (swelling of the soft tissues of the face, sinus mucosa or their necrosis, dysfunction of the pharyngeal muscular system, neurosensory deafness) were formulated, which could be explained by secondary ischemic tissue changes and impaired venous outflow of the soft tissues of the face. Also, the absence of a primary purulent focus of in­fection and septic changes in peripheral blood and cerebrospinal fluid in patients with a clinically confirmed diagnosis of CVT, confirmed the aseptic (primary) form of the disease. Patients with aseptic CVT are assigned direct anti­coagulant therapy and symptomatic therapy depending on the presence of cerebral and focal neurological symptoms, which is radically different from the therapeutic tactics used by patients with septic CVT. Thus, when conducting a differential diagnosis of different forms of CVT, for the choice of therapeutic strategy, in addition to the standard algorithm of examination of the patient should take into account the nature of changes in otolaryngological status.
Polymorphism of CYP3A4*1G gene as a predictor of the hepatotoxicity of antituberculosis therapy
Authors: Poludenko H.O. , Antonenko P.B. , Antonenko K.O. , Makarenko O.V.
Published: April 2022

The risk of anti-tuberculosis (ATB) drug-induced liver injury could be determined by genotype polymorphism of the xenobiotic-metabolizing enzymes. The aim of presented research was the investigation of an impact of CYP3A4*1G polymorphism on liver function in patients with TB during anti-tuberculosis therapy. There were analyzed case histories of 105 patients with newly diagnosed pulmonary TB at Odessa Regional TB Hospital in 2012-2014. We have considered their medical records at the beginning and at the end of inpatient treatment including activity of biochemical indices such as total bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutathione transferase (GGT). The genotype CYP3A4*1G, 20230G>A was detected by PCR. At the beginning of the treatment the level of studied biochemical indices was almost the same regardless of CYP3A4*1G genotype. After the conducted in-patient treatment the biochemical indices in fast metabolizers insignificantly increased, while the level of bilirubin dropped by 10.4% (p<0.05). In slow metabolizers after in-patient treatment the serum total bilirubin level increased by 8.0% (p<0.05), the activity of ALT raised by 67.2% (p<0.05), AST – by 37.4% (p>0.05), also the number of the patients with ALT and AST level beyond normal almost doubled. After completion of in-patient treatment in moderate and slow metabolizers serum GGT activity increased by 2.5 times (p<0.05) and 1.3 times (p>0.05) correspondently, among fast metabolizers – on the contrary, the num­ber of the individuals with increased GGT level dropped (p<0.05). Thus in slow metabolizers according to CYP3A4*1G genotype after completion of in-patient stage of anti-TB treatment the level of cytolysis and toxicity in­dexes was much higher than in fast metabolizers.  That is why detection of CYP3A4*1G genotype of TB patients at the beginning of TB treatment could help to recognize a group of the individuals with increased risk of liver injury during therapy.
Cytokine profile of bronchoalveolar secretion in prolonged course of community acquired pneumonia
Authors: Razumnyi R.V.
Published: April 2022

Despite existing studies on pathogenetic role of cytokine (CK) system in lung damage in pneumonia, there are still controversial issues of cytokine-mediated processes that lead to the prolongation of the inflammatory process in lung tissue in this pathology. The article presents the study of the cytokine profile of bronchoalveolar secretion (BAS) in the prolonged course of community-acquired pneumonia (CAP). To achieve the purpose of the research, in patients with prolonged CAP on the first and last 1-2 days of hospital stay the concentration of pro-inflammatory (IL-1β, IL-2, TNFα, IL-6, IL-8) and anti-inflammatory CK (IL-4 and IL-10) in BAS was determined. When studying the cytokine profile of BAS in the acute period of CAP, it was found that patients with a prolonged course of the disease subsequently had an increase in the concentration of pro-inflammatory CK (IL-1β, IL-6, IL-8, TNF-α and IL -2), reduction of anti-inflammatory (IL-4, IL-10) and more significant disproportion of the ratio of their opposition pools (IL-1β/IL-10 and TNF-α/IL-10) in BAS. In the conditions of the generally accepted therapy in patients with prolonged and not prolonged CAP course, various rate of improvement of indicators of CK in BAS is defined. In patients with prolonged CAP, the rate of progress of pro-inflammatory and anti-inflammatory CK was slower. At the time of discharge from the hospital, most patients had an imbalance of pro-inflammatory and anti-inflammatory CK with a predominance of pro-inflammatory activity in the bronchoalveolar space.