bluuebunny/crossref_metadata_2025 huggingface dataset:
Experimental study of the antiulcer effect of cryopreserved placenta extract on a model of acetylsalicylic acid-induced ulcerogenesis
Authors: Hladkykh Fedir Vol.
Published: July 2022

Introduction. The gastrotoxicity of nonsteroidal anti-inflammatory drugs is a leading side effect that significantly limits their clinical use, among other types of their toxicity (nephrotoxicity, hepatotoxicity, cardiotoxicity, etc.). Cryopreserved placenta extract has drawn our attention as a potential modifier of the ulcerogenic action of nonsteroidal anti-inflammatory drugs.

Aim. To characterize the cytoprotective properties of cryopreserved placenta extract by the condition of the mucous membrane of the proximal (esophagus and stomach) and distal (small and large intestine) parts of the gastrointestinal (GI) tract on the model of ASA-induced ulcerogenesis.

Material and methods. The study was performed using 28 male rats weighing 200-220 g. Subchronic ASA-induced ulcerogenesis of the digestive tract was reproduced by intragastrically administration to rats of ASA in a dose of 150 mg/kg. The effect of the studied drugs on the condition of the mucous membrane of the digestive tract was assessed macroscopically by the following criteria: edema, redness and hemorrhage on the surface of the mucous membrane. The ulcer index for each group of animals was calculated.

Results and discussion. Five doses of ASA 150 mg/kg cause damage to the esophagus, stomach, small and large intestines in all of the rats. The use of the proton pump inhibitor esomeprazole has pronounced gastrocytoprotective properties, but does not affect the ulcerogenic effect in the small intestine, and in the colon, it enhances it. This is indicated by ulcerative lesions of the colon in 57.1% of all rats administered ASA and esomeprazole, as well as in the folding of the gastric mucosa. In contrast, mild hyperemia of the gastric mucosa was seen in 28.6% of all rats and moderate hemorrhage in 57.1% of all rats due to the combined use of ASA and cryoextract placenta.

Conclusions. The use of cryopreserved placenta extract is statistically significantly (p <0.05) inferior to the antiulcer activity of esomeprazole in the stomach. Thus, the ulcer index on the background of the use of ASA and cryopreserved placenta extract was 0.97, and on the background of the use of ASA and esomeprazole – 0.39. In the distal parts of the GI tract cryoextract placenta showed cytoprotective properties against the background of induced ASA ulcerogenesis, in contrast to esomeprazole.
Experimental and Numerical Stress State Assesment in Refill Friction Stir Spot Welding Joints
Authors: Gadalińska Elżbieta , Kubit Andrzej , Trzepieciński Tomasz , Moneta Grzegorz
Published: July 2022

Refill Friction Stir Spot Welding (RFSSW) is a technology used for joining solid materials that was developed in Germany in 2002 by GKSS-GmbH as a variant of the conventional friction stir spot welding (FSSW) [1]. In the RFSSW technology, the welding tool consists of a fixed outer part and rotating inner parts, which are called a pin and a sleeve. The tool for RFSSW is designed to plasticize the material of the parts to be joined by means of a rotary movement. The design of the tool allows independent vertical movement of both elements of the welding tool. This allows obtaining spot welds without creating holes that could weaken the structure. The main advantage of RFSSW is the potential for replacing the technologies that add weight to the structure or create discontinuities, such as joining with screws or rivets. Thus, RFSSW has great potential in the automotive, shipbuilding and aviation industries. Furthermore, the technology can be used to join different materials that could not be connected using other joining methods. The main objective of this work is to understand the physical and mechanical aspects of the RFSSW method – including the residual stress state inside the weld and around the joint. The results of the investigations can help to determine optimal parameters that could increase the strength and fatigue performance of the joint and to prove the significant advantage of RFSSW connections over other types of joints. The work assumes the correlation of two mutually complementary investigation methods: numerical analyses and experimental studies carried out with diffraction methods. The comparison between numerical and experimental results makes potentially possible the determination of degree of fatigue degradation of the material by observing the macroscopic stress state and the broadening of the diffraction peak width (FWHM), which is an indicator of the existence of micro-stress related to the dislocation density and grain size.
Application of Laboratory Diffraction Methods in Characterization of Elements Made By Additive SLM Methods – State of the Art
Authors: Gadalińska Elżbieta , Pawliszak Łukasz , Moneta Grzegorz
Published: July 2022

The greatest challenge of widely developed incremental manufacturing methods today is to obtain, as a result of the manufacturing process, such components that will have acceptable strength properties from the point of view of a given application. These properties are indirectly determined by three key characteristics: the level of surface residual stress, the roughness of the component and its porosity. Currently, the efforts of many research groups are focused on the problem of optimizing the parameters of incremental manufacturing so as to achieve the appropriate level of compressive residual stress, the lowest possible porosity and the lowest possible roughness of parts obtained by 3D methods. It is now recognized that determining the level of these three parameters is potentially possible using experimental X-ray diffraction methods. The use of this type of radiation, admittedly, is only used to characterize the surface layer of elements, but its undoubted advantage is its easy availability and relatively low cost compared to experiments carried out using synchrotron or neutron radiation.
Certification of Testing Laboratories – The Basis of Reliability Among Research Vendors in Aviation
Authors: Wichniarz Marzena
Published: July 2022

Material characterization and assessment is a crucial stage in most of aviation and aeronautical research and a basis for further design and testing of more complex aircraft elements and structures. Material test’s reliability can only be guaranteed by conducting them at independent and reliable laboratories, operating based on a management system assessed by a third-party such as the accreditation according to the ISO / IEC 17025 or NADCAP or having the qualification of the second-party based on specific customer requirements. This paper introduces basic requirements for material testing laboratories according to accreditation systems and describes its responsibilities as qualified and reliable testing suppliers.
Research on Hovercraft – Fatigue Cracks in the Engine Frame
Authors: Szafran Krzysztof Stanisław , Michalczyk Marcin
Published: July 2022

Rescue patrol hovercrafts must meet the basic condition – high reliability of use in extreme conditions. The introduction to the work shows damage to the propulsion system and the fan tunnel structure resulting from a fatigue fracture of the attachment wound to the propulsion unit hull. In this paper, the author describes some ways of improving the engine frame structure. In the first phase of the exploitation crack testing of the hovercraft frame, the probable causes of damage were determined. The necessary output data for analysis of the load course were obtained from the operating documentation. The approximate number of variable load cycles acting on the frame truss rod was determined. Using the comparative testing methods, the service life of the frame was estimated. Probable resonance frequencies of the vibrating bars in the truss were determined. Vibration tests of the power transmission assemblies were carried out, which allowed to determine the amplitudes and frequencies of free vibrations. Finally, a modification of the frame shifting the resonant frequency range was proposed. In conclusions, changes to the design and a schedule of inspections were proposed. The newly designed engine frame should have an extended service life.
New Epipalaeolithic Sites Found in the Last 20 Years of the Manasseh Hill Country Survey in Eastern Samaria and the Lower-Middle Jordan Valley
Authors: Rosenberg Danny , Bar Shay
Published: July 2022

The Epipalaeolithic period of the southern Levant is well documented and has been studied for over 90 years. The period encompasses three major cultural complexes, namely the Early Epipalaeolithic Kebaran, the Middle Epipalaeolithic Geometric Kebaran, and the Late Epipalaeolithic Natufian. While the presence and characteristics of the Epipalaeolithic period have been widely discussed, some geographic regions have not yet received a comprehensive overview, and thus are frequently left outside the archaeological discourse. The current article surveys the available information regarding the Epipalaeolithic period in the Eastern Samaria Mountains and the Lower- Middle Jordan Valley, integrating old and new data into the discussion.
Excavations at Khirbet 'Aujah el-Foqa: Results from the 2020–2021 Seasons David Ben-
Authors: Ben-Shlomo David , Freikman Michael , Hawkins Ralph K.
Published: July 2022

This article will describe and discuss the results of the 2020–2021 seasons of the excavations at Khirbet ‘Aujah el-Foqa, a site in the southern Jordan Valley, north of Jericho. During these seasons, a section of the northern side of the site was excavated, including one complete structure. This structure, as well as the units around it, also contained a hasty abandonment or destruction layer from the Iron Age IIB similar to the one excavated in the southern part of the site. The article will illustrate reconstructed pottery from Area A, along with other finds. A large complex containing rooms and open areas appears to have been located in this area, although its function is still unclear. Finally, the reconstruction of the architecture will be discussed, along with the possible significance and function of the site.
Basic unconditional income: model, SWOT-analysis, foreign experience, specifics of application in the Russian Federation
Authors: Berezyuk S. A. , Gubin M. A. , Tokun L. V.
Published: July 2022

The relevance of the article stems from the fact that in today’s world, in order to maintain a quality of life, the state must pay increased attention to the economic and social well-being of citizens, and ensure all basic material needs of the individual without conditions or restrictions. One of the instruments of economic and social support for the population is the unconditional basic income. The aim of the study is to develop the concept for applying the unconditional basic income as one of the attractive methods for addressing poverty and eliminating economic and social inequalities in the Russian Federation. The key components of the poverty’s problem and the state’s approach to tackling it were analysed. Approaches to defining the term “unconditional basic income” and the phenomenology behind the term were explored. The key factors of social life, contributing to the practical implementation of unconditional basic income, were determined. A review of the world practices of its implementation is reflected and possibilities of its application in the Russian Federation are considered.
Transformation of tax instruments to stimulate investment processes
Authors: Gulkova E. L. , Karp M. V. , Tipalina M. V.
Published: July 2022

The article examines the practice of applying various tax instruments to stimulate largescale investment processes. The purpose of the study is to analyse tax instruments to stimulate these investment processes from the point of view of their impact on the final outcome. The authors decided tasks: to consider the taxes benefits and preferences as tools for stimulating large-scale investment processes; to identify opportunities for creating the most favorable tax climate for these investment projects; to assess the possibility of expanding such a tax administration tool as tax monitoring, subject to the inclusion of organisations implementing large investment projects as taxpayers. The authors’ recommendations and conclusions can be used in the development of conceptual provisions of tax policy both at the regional and state level in the field of tax regulation of investment processes.
Economic relations between Russia and Syria: investments, commodity turnover and prospects
Authors: Eid A. H.
Published: July 2022

This article explores the economic relations between the Russian Federation and the Syrian Arab Republic, considers Russian investments in Syria, and analyses the trade turnover. Based on the results of the study and the current geopolitical situation, the prospects for the development of economic relations between the two countries are shown. Using methods of analysis, comparison and a historical approach, the author has concluded that economic relations between Russia and Syria, although quantitatively insignificant, have great prospects for development. One of the prerequisites for the development of trade between Russia and Syria is the pressure of sanctions on these countries. Commodity turnover between these countries is characterised by a much larger flow in one direction – to Syria, which is not surprising, as Syria has been under sanctions since 2011 and is still on its way to economic recovery.
Development of an insurance industry image assessment index
Authors: Larina O. I. , Moryzhenkova N. V.
Published: July 2022

The article discusses the results of the study of consumer attitudes towards the insurance sector in the Russian Federation. A low level of financial literacy, cases of fraud by insurers lead to the formation of a negative image of the insurance industry, even if the respondents have a positive experience of using insurance products. In world practice the relationship between reputation management of companies and their financial condition has been proven, however, a quantitative assessment of the insurance sector image has been not carried out earlier. The article offers a methodology for assessing the insurance sector image? using the author’s index, and provides an example of its calculation based on the Russian insurance market. The developed indicator will allows to objectively assess the dynamics of consumer attitudes to insurance, and to conduct a cross-country comparison of the indicator.
Development of crowding-in as an alternative form of small and mediumsized businesses financing: foreign experience and Russian practice
Authors: Glukhov K. V. , Kulikov M. V.
Published: July 2022

The article presents a comprehensive analysis of legal and economic measures aimed at state support for small and medium-sized businesses in order for them to obtain an alternative source of financing using crowdinvesting platforms, and a consimilar foreign experience research. Based on statistical data, conclusions on the crowdinvesting platforms sector’s development and its interaction with small and medium-sized businesses are presented. Within the frameworks of the article, the emphasis is placed on a detailed study of foreign experience in the providing an alternative funding source. The advantages and disadvantages of this method in the Russian context have been shown. The study involved an analysis and synthesis of domestic and foreign anti-crisis measures.
Methodology of the remote audit efficiency
Authors: Lebedinskaya L. N. , Rozhkova N. K. , Rozhkova D. Yu.
Published: July 2022

Remote audit is performed using information and communication technologies to collect, store, retrieve, process, analyse and transmit information. Before the COVID-19 pandemic, remote audits were carried out on a relatively small scale (for example, checking enterprises with hazardous production) or in case of unforeseen circumstances. During the COVID-19 pandemic, businesses, regulators and households have been forced to switch to work remotely, based on existing and developing new technologies. This article analyses remote audits and their effectiveness. To do this, autors have been conducted 18 interviews with representatives of the audit profession (leading auditors, auditors) and audit clients. The result has been the identification of the main differences between the process of traditional and remote audit, difficulties and features. Based on existing methods for analysing the audits’ effectiveness, and using a balanced scorecard, we have developed a methodology for assessing the effectiveness of remote audits (including indicators that affect the effectiveness of only remote audits).
Psychological characteristics of women who choose conscious childlessness
Authors: Kozyreva V. V.
Published: July 2022

The article provides a review of the study of the problem of childlessness in foreign and domestic literature is presented. The results of the author’s research, revealing the psychological characteristics of women, choosing conscious childlessness, are presented. The characteristics of women who consciously choose childlessness for themselves and women with children have been described and analysed by a questionnaire to identify the dominant instinct, the questionnaire “Reproductive Motives”, the California Psychological Questionnaire. Among the psychological traits of childfree women, dominant traits aimed at social and interpersonal relationships, abilities for status, independence and flexibility, achievement through submission and through independence prevail, etc. They are aimed at domination, control of themselves and their lives, receiving material and social benefits from life, moreover, they do not want to bind themselves with responsibility for other people in general, and for children in particular.
HR Tech and staff training interaction
Authors: Kaufman N. Yu. , Zelentsova S. Yu.
Published: July 2022

The article explores the principles of building a competitive specialist in adigitally transformed economy, and presents the prerequisites that justify the development of staff training through the automation of HR technologies. The interpretation of the concepts «digital economy», «EdTech», «staff training», «gamification» is given. The main barriers preventing the implementation of HR Tech solutions in organisations are showed. The use of statistical analysis and comparison methods made it possible to present the areas of HR Tech, where digitalisation most actively improves and automates processes. It has been revealed that the main drivers of efficiency in the HR sphere can be modern tools and platforms that contribute to the introduction of automation in the personnel training system. The events of recent years have led to the understanding that it will no longer be possible to work effectively without the use of new technologies, therefore, the advantages of automating learning processes are highlighted. The role and area of responsibility of the training and development manager in the process of staff training has been established. Scenarios for solving the problem of a shortage of a digital specialist have been determined.
Managing the motivation provision of universities in the context of the educational process digitalisation
Authors: Kuzminova T. V. , Belova O. L.
Published: July 2022

The paper proposes a method for increasing the motivation of university teachers to work with digital technologies on the example of teaching foreign languages. The fear of complete displacement of the teacher by digital technologies leads to many ethical and psychological problems, resulting in a reluctance to use training programmes in the educational process. To increase the motivation of teachers to work in the digital environment, it is proposed to involve them in the use of digital educational technologies to adapt the work plans of disciplines to the preparation level of students entering universities. The specialists team composition required for the implementation of this method in practice has been formed. Additional factors for increasing the teachers motivation to work in a digital environment when working in a team have been shown. The proposed approach can be used in the implementation in digital educational systems of educational institutions.
Organisation management tasks formalisation
Authors: Raychenko A. V.
Published: July 2022

The publication presents the materials and results of the research and construction of the methodology and the methodology for formalising the tasks, procedures, functions of managing a socio-economic organisation as its main goal. Its formulation and achievement are ensured by the definition and resolution of the range of tasks for formalising the management of the formation, functioning and development of an organisation, the methods and results of solving which are considered in relation to digitalisation procedures. Their selection, description, adaptation to the requirements, conditions and possibilities of formalisation are identified, analysed and positioned in the process of substantiating the methodology, developing and testing the methodology for constructing a spectrum of the most constructive functional positions for digitalisation. The examples of their selection, definition and positioning given in the publication methodically substantiate and adaptively demonstrate the relevance of the research being conducted, the constructiveness and relevance of the results obtained.
Inequality degree within the country in the context of realising the Sustainable Development Goals
Authors: Davletshina L. A. , Telyuk M. S. , Sadovnikova N. A.
Published: July 2022

The article assesses the inequality degree within Russia in the context of realising the Sustainable Development Goals. The review of foreign and domestic scholarly writings, focusing on current issues of implementation and achievement of the Sustainable Development Goals, is presented. The authors reviewed the indicators development degree of sustainable development in Russia as of December 2021. It is determined that Goal 3 “Ensure healthy lifestyles and promote well-being for all at all ages” is the most fully disclosed. Based on the National Indicators of Goals 3, an original system of statistical indicators for assessing inequality between regions has been compiled and substantiated. According to the indicators presented in the above-mentioned system, the clustering procedure of the Russian regions was carried out, and the assessment and interpretation of the selected clusters were given. The content distribution into typological groups was practically not influenced by territorial affiliation. A significant role was played by direct indicators, included in the indicator system, and indirect factors, affecting both the development of the region and the socio-economic well-being of the inhabitants of these regions. The authors believe that there remains relevant to study the transformations that the two divergent flows will take place in the coming years: 1) existing national projects and state programmes to solve the tasks and achieve the planned values formulated in the National Set of Sustainable Development Goals Indicators in the part of Goal 3; 2) the current epidemiological situation, which in the period 2020–2021 has already made tangible changes in the size and composition of the population.
Using network partnerships in management consulting
Authors: Soblirov A. A.
Published: July 2022

The article discusses the use of network partnership in the process of interaction between the consultant and the client in the framework of the search, the client’s receipt of investments and further project support. Traditionally, the process of interaction between the client and the consultant is presented in such a way that only these two parties are the main participants in the consultation process. The article discusses the experience of building a multidisciplinary complex consulting process, in which many participants are involved. This experience is based on the practice of the Business Angels of Russia network community. This article analyses the practice of mainly small consulting organisations that are very different from large ones and provide significantly more customised services. The consulting related to investing funds in the client’s business is in the author’s focus. At the same time, only clients belonging to small and medium-sized enterprises naturally stand out in the work. As a rule, they do not seek advice from wellknown and renowned brands in the field of consulting services. As a rule, they do not have enough money for their services, and large consulting firms themselves choose mainly large clients to work with.
Distance education through the eyes of teachers and students: key issues
Authors: Robustova E. V. , Shcherbakova I. K.
Published: July 2022

The article analyses the experience of Russian education digitalisation in the context of restricting the social contacts due to the COVID-19 pandemic. The results of a survey of teachers and students of the State University of Management on the quality of education during the pandemic and the difficulties that the participants of the educational process overcame in connection with the emergency transition to the online format are presented. The problems of psychological, pedagogical, didactic, socio-psychological and technical nature that the participants of the educational process encountered when organising online learning activities have been identified by the methods of expert analysis. As a result of the analysis of respondents’ opinions and their comparison with the opinions of education researchers, a generalisation was made: despite the fact that e-education has firmly entered our lives, in the near future, at the bachelor’s level, the online learning format will not be able to replace the traditional format, since it does not provide a high quality of knowledge transfer and assimilation. At the same time, it is emphasized that the indisputable advantages of learning using electronic educational environments should not be overlooked, which aims to develop the principles and technologies of a “hybrid” bachelor’s education system, providing for a combination of online and offline formats in accordance with the requests and specific conditions of educational activities, depending on the orientation and profile of training.
A Photochemical Method to Evidence Directional Molecular Motions
Authors: Regen-Pregizer Benjamin Lukas , Mayer Peter , Hampel Frank , Dube Henry
Published: July 2022

Light driven synthetic molecular motors represent crucial building blocks for advanced molecular machines and their applications. A standing challenge is the development of very fast molecular motors able to perform rotations with kHz, MHz or even faster frequencies. Central to this challenge is the direct experimental evidence of directionality because analytical methods able to follow very fast motions rarely deliver precise geometrical insights. Here, a general photochemical method for elucidation of directional motions is presented. In a macrocyclization approach the molecular motor rotations are restricted and forced to proceed in two separate ~180° rotation-photoequilibria. Therefore, all four possible photoinduced rotation steps (clockwise and counterclockwise directions) can be quantified. Comparison of the corresponding quantum yields to the unrestricted motor delivers direct evidence for unidirectionality. This method can be used for any ultrafast molecular motor even in cases where no high energy intermediates are present during the rotation cycle.
Post-Combustion CO2 capture by vacuum swing adsorption using a hydrophobic metal-organic framework (MOF), CALF-20: Multi-objective optimization and experimental validation
Authors: Nguyen Tai , Shimizu George , Rajendran Arvind
Published: July 2022

In this paper, the ability of CALF-20, a hydrophobic metal-organic framework (MOF), to capture CO2 from dry flue gas (15/85 mol% of CO2/N2) using two different adsorption configurations, basic four-step vacuum swing adsorption (VSA), and four-step with light-product pressurization (LPP) was evaluated. Pareto curves, for the simultaneous maximization of CO2 purity and recovery, were generated. Five points from each Pareto curve representing five different process conditions were chosen to experimentally validate the model prediction. The experiments resulted in a CO2 purity and recovery of 95%, and 70%, respectively for the basic four-step cycle, while the four-step LPP resulted in 95% purity and 90% recovery, meeting US Department of Energy targets. The temperature history, the pressure transient, and the flow rate of different steps were in good agreement with the model predictions. The results of this study confirmed that CALF-20 is capable of separating CO2 from dry flue gas, demonstrating the potential of the MOF for practical separations.
An Object-Oriented Framework to Enable Workflow Evolution across Materials Acceleration Platforms
Authors: Leong Chang Jie , Low Kai Yuan Andre , Recatala-Gomez Jose , Velasco Pablo Quijano , Vissol-Gaudin Eleonore , Tan Jin Da , Ramalingam Balamurugan , Made Riko I , Pethe Shreyas Dinesh , Sebastian Saumya , Lim Yee-Fun , Khoo Zi Hui Jonathan , Bai Yang , Cheng Jayce Jian Wei , Hippalgaonkar Kedar
Published: July 2022

Progress in data-driven self-driving laboratories for solving materials grand challenges has accelerated with the advent of machine learning, robotics and automation but usually designed with specific materials and processes in mind. To develop the next generation of Materials Acceleration Platforms (MAPs), we propose a unified framework to enable collaboration between MAPs, leveraging on object-oriented programming principles using which research groups around the world would be able to effectively evolve experimental workflows. We demonstrate the framework via three experimental case studies from disparate fields to illustrate the evolution of, and seamless integration between workflows, promoting efficient resource utilisation and collaboration. Moving forward, we project our framework on three other research areas that would benefit from such an evolving workflow. Through the wide adoption of our framework, we envision a collaborative, connected, global community of MAPs working together to solve scientific grand challenges.
Uzun QT sendromu ile takip edilen çocuk hastalar- Yakın yaman takip ve sonuçları- tek merkezli bir çalışma
Authors: DUMAN Derya , KARPUZ Derya
Published: July 2022

Amaç: Uzun QT Sendromu (UQTS) çocuklarda hayatı tehdit eden aritmilere ve ani kardiyak ölüme neden olabilen, genetik olarak geçen veya edinilmiş kardiyak bir kanalopati bozukluğudur. Klinik özellikler değişken olabilir. Bu çalışmada kliniğimizde takip ettiğimiz doğumsal (konjenital) ve edinilmiş UQTS olan hastaların verilerini inceleyerek literatürle karşılaştırmayı amaçladık. Yöntem: 2018 Ocak – 2021 Ağustos tarihleri arasında kliniğimizde UQTS tanısı alarak takip edilen hastaların verilerini bilgisayar ve dosya sistemi üzerinden geriye dönük olarak taradık. Bulgular: UQTS tanısı alan 26 hasta tespit edildi. Bunların 21’i (10 erkek) doğumsal, beşi (dört erkek) edinilmiş UQTS idi. Doğumsal UQTS’de ortalama yaş 9.83±4.24 yıl iken edinilmişte 12.6±4.87 yıldı. Doğumsal tipte en sık asemptomatik vakalar vardı (10/21). Bunu dört vakada nöbet/epilepsi, iki vakada ise stresle bayılma takip etmekteydi. İki hasta ise kardiyak arrest ile acile gelmişti. Ortalama Schwartz skoru 4.69±2.19 (1-8) idi. 11 hastada patojenik mutasyon tespit edildi. Semptomatik olan ve QTC 470 msn olan her hastaya beta blokör tedavi başlandı. İzlemde bir hastaya implante kardiyoverter-defibrilatör (ICD) takıldı. Edinilmiş UQTS’de en sık semptom bradikardi idi (5/5). Torsades de Pointes (TdP) olup tedavi gerektiren bir hasta oldu. En sık neden ilaçlar ve hipokalemi idi. Tüm hastalar ortalama 18.45±14.52 ay (3-36 ay) takip edildiler ve bu süreçte ölen hasta olmadı. Major kardiyak olaylar ve semptomlar göz önüne alındığında T dalga alternansı, QTC>500 msn olması, kız cinsiyet ve Jervell Lange-Nielsen Sendromu ile hipokalemi önemli risk faktörleri olarak sayıldılar. Sonuç: UQTS’nin ayırıcı tanıda akılda tutulması ve hastalığın erken tanısıyla ani kardiyak ölüm önlenebilir. Hastaların semptom, risk durumları ve doğumsal veya edinsel UQTS olmasına göre tedavi planı değişecektir.
Akut miyokard infarktüslü hastalarda perkütan koroner girişim sonrası no-reflow fenomeni gelişimi üzerine klopidogrel ile tikagrelorun etkisinin karşılaştırılması
Authors: YEŞİL Emrah , UYAR Hakan , ÖRSÇELİK Özcan , ÖZKAN Buğra , ÇELİK Ahmet , ÖZCAN İsmail Türkay , AKKUŞ Mehmet Necdet
Published: July 2022

Amaç: No-reflow fenomeni (NRF) miyokard reperfüzyonunu etkileyen en önemli faktörlerdendir. Bu çalışmada perkütan koroner girişim (PKG) uygulanan akut miyokard infarktüs(AMİ) lü hastalarda önyüklemede kullanılan tikagrelorun ve klopidogrele karşı NRF gelişimi üzerine olan etkisini araştırdık. Yöntem: Tek merkezli ve retrospektif çalışmamıza AMİ tanısıyla, PKG uygulanmış 200 hasta alındı. PKG öncesi verilen antiplatelet rejimine göre hastalar klopidogrel veya tikagrelor yüklenen hastalar olarak ayrıldı. NRF tanımlamada TIMI akım sınıflaması veya işlem sonrası ST segment rezolüsyonundan yararlanıldı. No-reflow gelişenler ve normal akım sağlananlar arasında belirtilen parametrelerdeki farkın anlamlılığı ve tikagrelorla klopidogrelin NRF üzerine olan etkisi değerlendirildi. Bulgular: No-reflow gelişenler ve normal akım sağlananlar arasında bazal karakteristik özellikler açısından fark yoktu. Tikagrelor yüklenen hasta grubunda ST elevasyonlu miyokard infaktüslü hasta sayısı daha yüksekti (p=0.013). No-reflow gelişen grupta yaş, aspartat aminotransferaz (AST), C-reaktif protein (CRP), pik CK-MB seviyeleri, diyabetes mellitus (DM) oranı, stent uzunluğu, stent sayısı, ve düşük ejeksiyon fraksiyonlu hasta sayısı anlamlı olarak yüksek bulundu. Tikagrelor yüklenen hastalarda NRF gelişme oranı anlamlı olarak düşüktü( %19 p=0.001). Bu düşüklük yaş, DM, AST ve CRP seviyeleri, yerleştirilmiş stent sayısı ve miyokard infarktüsü tipini de kapsayan diğer bağımsız değişkenlerden bağımsızdı (Odds değeri = 0.228, %95 güven aralığı = 0.102-0.512, p<0.001). Sonuç: Tikagrelorun no- reflow gelişimini önlemede klopidogrele üstün olduğu görüldü.
Geç başlangıçlı romatoid artritli hastalarda yalnızlık hissi: Hastalık aktivitesi ve psikososyal faktörler ile ilişkisi
Authors: ÖNDER Mustafa Erkut , YILDIRIM Adem
Published: July 2022

Amaç: Yalnızlık hissi, kronik hastalıklar ve ağrılı durumlar ile şiddeti artan, oldukça yaygın görülen bir durumdur. Bu çalışmanın amacı, geç başlangıçlı romatoid artritli (RA) hastalarda yalnızlık hissinin araştırılması ve yalnızlık hissi ile hastalık aktivitesi ve psikososyal durum arasındaki ilişkinin incelenmesidir. Yöntem: Çalışmaya hastalık başlangıç yaşı 60 ve üzeri olan 44 RA'lı hasta ve 44 kontrol dahil edildi. Tüm katılımcıların sosyodemografik özellikleri, Beck Depresyon Ölçeği (BDÖ) ve Beck Anksiyete Ölçeği (BAÖ), Çok Boyutlu Algılanan Sosyal Destek Ölçeği ve UCLA Yalnızlık Ölçeği kısa formu (ULS-8) skorları kaydedildi. Ek olarak RA’lı hastaların eritrosit sedimantasyon hızı ve C-reaktif protein değerleri, Görsel Analog Skala-ağrı, Hastalık Aktivite Skoru ve Sağlık Değerlendirme Anketi (HAQ) skorları kaydedildi. Bulgular: RA’lı hastalarda kontrollerle karşılaştırıldığında depresyon skorları ile ULS-8 skorları daha yüksek ve algılanan sosyal destek skorları daha düşüktü ancak anksiyete açısından iki grup arasında fark yoktu. RA'lı hastalarda hem yalnızlık hem de algılanan sosyal destek BDÖ, BAÖ ve HAQ skorları ile korelasyon göstermekteydi. Aktif hastalığı olan grupta remisyona giren hastalara göre anksiyete ve depresyon puanlarının daha yüksek, algılanan sosyal desteğin daha düşük ve yalnızlık hissinin daha fazla olduğu belirlendi. Sonuç: Geç başlangıçlı RA hastalarında yalnızlık hissi; depresyon, algılanan sosyal destek, fonksiyonel durum ve hastalık aktivitesi ile ilişkilidir. Yaşlı bireylerde morbiditeyi artıran bir faktör olan yalnızlık, geç başlangıçlı RA’lı hastalarda daha şiddetli olmaktadır.
Energy audit of thermal power plant: a literature survey
Authors: Sudheer Chandra , Tanu Rizvi
Published: July 2022

Energy consumption has increased dramatically and steps towards the energy efficiency goal and emphasizes that an energy audit is an ongoing operation. It addresses the feasible activities, such as how to conserve and efficiently use our limited resources, and identifies how it reduces the capacity and how to translate these efforts into reality. A plant or facility may undergo an energy audit to determine energy consumption and energy conservation practices, as well as where and how energy is used. Improved procedures, better tools, and more efficient equipment can help to save energy.
Model of preparing podcasts as a contemporary strategy for encouraging reading literacy and reading culture
Authors:   Maribor Library, Popović Sabina Fras , Vilar Polona ,   University of Ljubljana
Published: July 2022

"The paper presents and analyzes the preparation and application of a modern strategy promoting reading literacy and reading culture, its scope, responsiveness and usefulness the professional environment and the wider social environment. Action research with the method of observation (system diaries) and analytical research (survey method) were used, which were conducted as part of a case study - this is the first such example of the use of modern strategies the Slovenian library space. Data were obtained by observing the design, preparation, implementation and evaluation of the selected modern strategy, ie podcasts. The phases of the action research are: 1. planning and creating podcasts, 2. implementing podcasts in practice, 3. determining the perception of podcasts in professional circles, 4. monitoring and determining the use of podcasts. In the third phase, analytical research was used to determine the perceptions of podcasts among professionals. The result is a five-step model of preparing podcasts in the public library for the purpose of encouraging thinking about reading literacy and reading culture. The results obtained in the third and fourth phases speak in favor of the use of such a strategy for this purpose. Research limitations are tied to one case study, which includes a large enough sample. Could be the starting point for a more extensive comparative study. The model highlights the importance of linking theory and practice and the use of modern strategies in the field of promoting reading literacy and reading culture."
Cold War Blues: Coastal Restoration of Shikhov Beach In a Post Oil World
Authors:   , Rowland Mathew
Published: July 2022

The oil industry is responsible for massive amounts of pollution across the world. A significant amount of this is due to the impact of large infrastructure created by drilling operations, which are hostile work environments and often damage the ecosystem they inhabit. Because Oil is one of the primary energy sources around the world its continued exploitation is guaranteed to happen for decades to come. As technological advancements facilitate new ways to obtain oil for the ever increasing demand, old facilities and their megastructures are abandoned with no plan for re-use.

This thesis is an exploration into architecture’s current role as a facilitator of offshore oil infrastructure. It explores the scale of investment for the multi-national corporations and how this investment is disposed of after there is no more oil in the well. More often than not there is little consideration as to what happens after the drilling and this causes a multitude of problems that push the area closer to the brink of ecological disaster.

The design project proposes deploying new machinery onto an architectural construction to develop a symbiotic relationship between the two. The way new machinery interacts with the architecture it inhabits is considered by discussing the life cycle of current technology and what future developments might hold for the sustainability of coastal regions.
Road to Restoration
Authors:   , Lock Thomas
Published: July 2022

Anxiety and depressive disorders are the second leading cause of health loss for New Zealanders. In particular, students are primarily a high-risk group. They are at the age when most when mental health disorders first present themselves. They are often living away from home for the first time, burdened with the pressures of academic expectations from themselves and by others. A recent survey from Australia identified that almost 70 percent of students aged between 17 and 25 rate their mental health as “poor”(National Tertiary Student Well-being Survey 2016). Almost 80 percent reported feeling anxious, 60 percent had feelings of hopelessness or worthlessness and just over 35 percent experienced thoughts of self-harm or suicide.

Research finds that architecture can play an essential role in providing an environment conducive to positive well-being. However, the facilities devoted to student health are typically neglected and located in unused spaces.

This research examines the role of architecture in providing therapeutic environments for self-directed restorative practices through the arrangement of both the sensory and the non-sensory.

This thesis uses an extensive literature and case study review to analyse and explore a design-led research project on anxiety and architecture. This is achieved by exploring the relationship between architecture and scale, prospect/ refuge, navigation, transparency, and landscape.

Using the former Gordon Wilson flats location, this research is strategically positioned between the university through a pedestrian bridge and student accommodation, mediating between student housing and the university. This thesis employs a central spine supporting a variety of multi-sensory options and student spaces, providing opportunities for social encounters or opportunities for quiet reflection.

The research finds that architecture commonly adopts a medical care approach to mental health design with a focus on cost rather than rather than taking a holistic approach with a focus on well-being. This research contributes to an emerging but still under-examined area of vital architectural importance.
A Research on the Path of Ideological and Political Education in Agricultural Colleges and Universities to Promote Rural Revitalization
Authors: Huang Yali , Liu Fei
Published: July 2022

Agricultural colleges and universities shoulder the arduous task of cultivating talents for rural revitalization, in which ideological and political education is the key link in talent training. Ideological and political education helps cultivate reliable talents for rural revitalization, stimulate the endogenous power of rural revitalization, and realize direct and indirect promotion of rural revitalization. However, there are still many issues in ideological and political education in terms of educational concept, educational content, and educational model. Hence, it is necessary to strengthen the role of ideological and political education in promoting rural revitalization by clarifying the goals and concepts of ideological and political education in agricultural colleges and universities, strengthening the cultivation of students’ awareness of rural revitalization services, and innovating ideological and political education models.
Treatment of Chronic Heart Failure Complicated with Anxiety and Depression Using Traditional Chinese and Western Medicine
Authors: Dong Mili , Fan Hong
Published: July 2022

Chronic heart failure (CHF) is the terminal stage of various heart diseases, and is the main cause of death from cardiovascular disease. In recent years, the prevalence of CHF combined with anxiety and depressive state has shown an upward trend, and this paper was aimed to provide a reference for the diagnosis and treatment of CHF combined with anxiety and depression using Traditional Chinese medicine (TCM) and Western medicine.
Epigenetic Alterations in Depression and Treatment Perspectives
Authors: Bai Luyan
Published: July 2022

The global incidence of depression is progressively on the rise and tends to occur more in younger generations, however the pathogenesis of the disease is unclear. Meanwhile, epigenetics is a modification which produces heritable alterations in the DNA sequence, which ultimately manifest in phenotypic differences. It has been suggested that the onset and development of depression can be tentatively explained by the combination of epigenetic and environmental factors. This paper reviews epigenetic changes in depression in the context of environmental factors, including DNA methylation modifications, histone modifications, and non-coding RNA regulation.  An epigenetic-based therapeutic outlook was also proposed in this paper, which initially elucidates the epigenetic mechanisms underlying the pathogenesis of depressions and provides a theoretical basis for the treatment of depression.
Correlation Analysis Between BDNF and Postoperative Cognitive Dysfunction in Aged Rats
Authors: Zhang Yuming , Wang Hui , Chen Fang , Wang Jun , Bai Ning
Published: July 2022

Objective: To investigate the relationship between BDNF and postoperative cognitive dysfunction among aged rats. Methods: 36 SPF healthy aged male SD rats were randomly assigned to a control group and a model group, respectively, with 18 rats in each group. Abdominal exploration was performed on the rats in the model group after anesthesia, while the rats in the control group were not operated on after anesthesia. The escape latency and swimming distance of the two groups were analyzed on a day prior to surgery as well as on the first day, third day, and seventh day following surgery; the expression levels of BDNF protein in the hippocampus of rats in the two groups were compared on the first day, third day, and seventh day following surgery; the correlation between BDNF and escape latency and swimming distance was analyzed. Results: The escape latency and swimming distance of the rats in the control group on a day prior to surgery, the first day, third day, and seventh day following surgery did not differ significantly (p > 0.05), but those in the model group had significant behavioral difference (p < 0.05). On a day prior to surgery, the rats in both groups showed no significant behavioral difference in escape latency and swimming distance (p > 0.05), but on the first day, third day, and seventh day following surgery, the escape latency and swimming distance of the rats in the model group were significantly longer than those in the control group (p < 0.05). In the control group, there was no significant difference in the protein expression of BDNF in the hippocampus of rats on the first day, third day, and seventh day following surgery, but there was significant difference in the model group. On the first day, third day, and seventh day following surgery, the BDNF protein expression level in the rats’ hippocampus of the control group was significantly higher than that of the model group (p < 0.05). The data from Pearson correlation analysis confirmed that BDNF protein expression is negatively correlated with escape latency (r = -0.567, p < 0.001) and swimming distance (r = -0.623, p < 0.001). Conclusion: In aged rats, the BDNF protein expression level decreases, and the degree of cognitive dysfunction increases after surgery.
Intelligent Construction Technology of Hyperbolic Curtain Wall
Authors: Lu Tong , Wang Shuai , Wu Ke-yang , Wang Li , Liu Chen , Yang Wei
Published: July 2022

Taking the hyperbolic glass curtain wall project of the Wuhan Jinyinhu Commercial Plaza as an example, the characteristics of different curved glass forming technologies were analyzed in this paper. Combined with the actual engineering situation, the curved steel process is selected to produce the hyperbolic glass curtain wall, and the application of BIM technology in the quality control of hyperbolic glass curtain wall in the production process was analyzed, and the effects of heating condition, bending time, cooling condition, and bending tempering error in the manufacturing accuracy of the curved glass curtain wall were studied, in hope that this project can provide practical reference for similar curtain wall design construction in the future.