bluuebunny/crossref_metadata_2025 huggingface dataset:
Pre-Frailty Phenotype and Arterial Stiffness in Older Adults Free of Cardiovascular Diseases
Authors: Macêdo Geovani Araújo Dantas , Freire Yuri Alberto , Browne Rodrigo Alberto Vieira , Câmara Marcyo , Cabral Ludmila Lucena Pereira , Schwade Daniel , Paulo-Pereira Ronildo , Silva Raíssa de Melo , Silva Alana Monteiro Bispo , Farias-Junior Luiz Fernando , Duhamel Todd A. , Costa Eduardo Caldas
Published: October 2022

Purpose: Arterial stiffness is a subclinical marker of cardiovascular disease (CVD). The pre-frailty phenotype is associated with a higher risk for CVD. This study investigated the association between the pre-frailty phenotype and arterial stiffness in community-dwelling older adults without diagnosed CVD. Methods: In total, 249 community-dwelling older adults aged 60–80 years were included in this cross-sectional study. The pre-frailty phenotype was defined by the standardized Fried criteria (muscle weakness; slow walking speed; low physical activity; unintentional weight loss; self-reported exhaustion). Participants with one or two standardized Fried criteria were classified as pre-frail and those with zero criteria as robust. Arterial stiffness was measured by aortic pulse wave velocity (aPWV). The data were analyzed using the generalized linear model. Results: From 249 participants (66.1 ± 5.3 years; 79.5% females), 61.8% (n = 154) were pre-frail and 38.2% (n = 95) robust. Pre-frail older adults had a higher aPWV (β = 0.19 m/s; p = 0.007) compared to their robust peers. Conclusions: The pre-frailty phenotype was associated with higher arterial stiffness in community-dwelling older adults aged 60–80 years. Pre-frail older adults may have a higher risk for CVD.
Effects of Parental Migration on Dental Caries of Six- to Eight-Year-Old Children Using Structural Equation Modeling
Authors: Liu Sichen , Chongsuvivatwong Virasakdi , Zhang Shinan , Thearmontree Angkana
Published: October 2022

This cross-sectional study aimed to document the relationship between dental caries, oral health behaviors, and the duration of parental migration in rural Yunnan, China, from September to December 2020. Seven rural primary schools with high parental migration were studied. The oral health status of 500 six- to eight-year-old students was assessed using clinical examination and caregivers’ interviews. A total of 51.8% of the children had at least one parent absent for at least 6 months (left-behind children). Among those children with parental migration <6 months, 40.0% consumed sugar twice or more daily and 82.8% of those with parental migration from 6 to 12 months brushed once a day or less. The percentage of daily sugar consumption twice or more and brushing once or less among those without parental migration were 36.0% and 68.6%. Prevalence of caries in permanent teeth (DMFT) in children without parental migration and those whose parental migration <6 months, 6 to <12 months, and ≤12 months were 30.9%, 20.0%, 28.7% and 19.8%, respectively. Out of several other causal pathways between parental migration and dental caries, our structural equation model delineated that sugar consumption is the important mediator variable. Special education programs may be needed to educate caregivers on sugar consumption for the left-behind children in rural areas.
Validation and Translation of the Relational Aspect of Care Questionnaire into the Malay Language (RAC-QM) to Evaluate the Compassionate Care Level of Healthcare Workers from the Patient’s Perspective
Authors: Mohamed Noor Noorhidayu Monyati , Ibrahim Mohd Ismail , Hairon Suhaily Mohd , Mohd Zain Maizun , Satiman Mohd Saiful Nazri
Published: October 2022

Background: Compassionate care has been increasingly highlighted in the past few decades worldwide, including in Malaysia. Despite acknowledging its importance, Malaysia still lacks a validated tool that can be used to assess the level of compassionate care from the patient’s perspective. Therefore, this study aims to validate and translate the Relational Aspect of Care Questionnaire (RAC-Q) into the Malay language. Methods: Permission to use and translate the original RAC-Q into the Malay language was obtained. The RAC-Q was then translated into the Malay language following the 10 steps proposed for the translation of a patient-reported outcome questionnaire. A pretest was conducted based on 30 inpatients to assess the appropriateness and clarity of the finalized translated questionnaire. A cross-sectional study was performed based on 138 inpatients from six adult wards of a teaching hospital so as to validate the translated questionnaire. The data were analyzed using R software version 4.1.3 (R Core Team, Vienna, Austria, 2020). The results were presented descriptively as numbers and percentages or means and standard deviations. A confirmatory factor analysis was performed using robust estimators. Results: The analysis showed that the measurement model of the RAC-Q Malay version (RAC-QM) fits well based on several fit indices: a standardized factor loading range from 0.40 to 0.73, comparative fit index (CFI) of 0.917, Tucker–Lewis fit index (TLI) of 0.904, root mean square error of approximation (RMSEA) of 0.06, and a standardized root mean square residual (SRMR) of 0.073. It has good reliability, with a Cronbach’s alpha of 0.857 and a composite ratio of 0.857. Conclusion: The RAC-QM demonstrated good psychometric properties and is valid and reliable based on the confirmatory analysis, and it can thus be used as a tool for evaluating the level of compassionate care in Malaysia.
Development and Validation of a Nursing Work Interruption Scale
Authors: Yu Eun-Jeong , Lee Eun-Nam
Published: October 2022

Work interruption disturbs nurses’ flow of thinking, diminishes work efficiency, induces burnout, and causes errors that can threaten patients’ lives. Therefore, it is important to identify the causes and measure the extent of work interruption. This study developed a self-report scale and established its validity and reliability for use in hospital settings. Through literature review and in-depth interviews with nurses, we identified two components and developed 25 preliminary items. These items were reviewed by nursing experts for content validity and pilot tested among 20 hospital nurses; subsequently, a 16-item preliminary instrument was finalized. A total of 359 questionnaires were included in the final analysis, and exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were performed. Two factors and 12 items were derived from two rounds of EFA, with a cumulative percentage of variance of 55.73%. Construct validity was established through CFA. The predictive validity and internal consistency reliability of the developed scale were also established. Thus, the 12-item Work Interruption Measurement Scale for Nurses comprising two domains (human and environmental factors) was developed. This scale can be useful in assessing work interruption experienced by nurses and for developing and assessing the effectiveness of interventions pertaining to nurses’ work interruption.
Impacts of the COVID-19 Pandemic upon Chinese Positive Traits
Authors: Zhao Liang , Zhao Yukun , Wu Yiwen , Ding Xiaojun , Yu Feng , Peng Kaiping
Published: October 2022

Will Chinese people change in terms of their character strengths when disasters strike? As far as the most recent COVID-19 pandemic is concerned, we provide an explorative answer from the impacts of positive traits included in the Values in Action Classification of Strengths upon Chinese people. We conducted a large-scale online survey from 1 January 2019 to 13 February 2020, with 12,878 respondents nationwide, covering all the administrative regions in China and all age intervals. The changes in the 24 character strengths before and during the pandemic were compared. Results revealed a significant increase in teamwork triggered by the pandemic among Chinese people. Fine-grained differences in demographic variables were also examined. Results showed that the COVID-19 pandemic significantly boosted teamwork for both males and females. Concerning age differences, only younger adults (18–25-year-old) showed a significant increase in teamwork. Besides this, it was also discovered that females always performed a higher teamwork tendency than males, and the elderly higher than the younger, regardless of the pandemic.
Depth-Camera-Based Under-Blanket Sleep Posture Classification Using Anatomical Landmark-Guided Deep Learning Model
Authors: Tam Andy Yiu-Chau , Zha Li-Wen , So Bryan Pak-Hei , Lai Derek Ka-Hei , Mao Ye-Jiao , Lim Hyo-Jung , Wong Duo Wai-Chi , Cheung James Chung-Wai
Published: October 2022

Emerging sleep health technologies will have an impact on monitoring patients with sleep disorders. This study proposes a new deep learning model architecture that improves the under-blanket sleep posture classification accuracy by leveraging the anatomical landmark feature through an attention strategy. The system used an integrated visible light and depth camera. Deep learning models (ResNet-34, EfficientNet B4, and ECA-Net50) were trained using depth images. We compared the models with and without an anatomical landmark coordinate input generated with an open-source pose estimation model using visible image data. We recruited 120 participants to perform seven major sleep postures, namely, the supine posture, prone postures with the head turned left and right, left- and right-sided log postures, and left- and right-sided fetal postures under four blanket conditions, including no blanket, thin, medium, and thick. A data augmentation technique was applied to the blanket conditions. The data were sliced at an 8:2 training-to-testing ratio. The results showed that ECA-Net50 produced the best classification results. Incorporating the anatomical landmark features increased the F1 score of ECA-Net50 from 87.4% to 92.2%. Our findings also suggested that the classification performances of deep learning models guided with features of anatomical landmarks were less affected by the interference of blanket conditions.
Evaluation of the Effectiveness of Rural Revitalization and an Improvement Path: A Typical Old Revolutionary Cultural Area as an Example
Authors: Liu Yang , Qiao Jiajun , Xiao Jie , Han Dong , Pan Tao
Published: October 2022

At present, the focus of global attention is on implementing rural revitalization strategies. However, constructing a set of scientifically based evaluation indexes for the evaluation of the effectiveness of rural revitalization implementation, exploring the implementation plan for rural revitalization, has become a common concern and a focus of discussion in political and academic circles. This study used a typical rural revitalization demonstration area in China as an example. We proposed a theoretical framework for rural revitalization research and constructed an index evaluation system for the evaluation of the effectiveness of rural revitalization implementation and influencing factors from two perspectives: material life and spiritual life. The results were as follows: Differences were found in the implementation effectiveness of rural revitalization strategies in the study area; especially, in areas with obvious rural cultural characteristics, their implementation level was relatively high. The implementation effectiveness of rural revitalization strategies was the result of multi-factor interactions. The village greening rate, innovation ability, and the age of village supporters were the main factors affecting rural revitalization, and the interaction effects of a village’s innovation ability and other factors were significant. Therefore, we argue that in the process of promoting the sustainable development of villages, it is necessary to prominent the characteristics of village construction and improve the effectiveness of the implementation of village revitalization strategies at both the material and spiritual levels.
Are Ingested or Inhaled Microplastics Involved in Nonalcoholic Fatty Liver Disease?
Authors: Auguet Teresa , Bertran Laia , Barrientos-Riosalido Andrea , Fabregat Blanca , Villar Beatriz , Aguilar Carmen , Sabench Fàtima
Published: October 2022

Nonalcoholic fatty liver disease (NAFLD) has emerged as the predominant cause of chronic liver injury; however, the mechanisms underlying its progression have not been fully elucidated. Pathophysiological studies have stated that NAFLD is significantly influenced by dietary and environmental factors that could participate in the development of NAFLD through different mechanisms. Currently, “plastic pollution” is one of the most challenging environmental problems worldwide since several plastics have potential toxic or endocrine disputing properties. Specifically, the intake of microplastics (MPs) and nanoplastics (NPs) in water or diet and/or the inhalation from suspended particles is well established, and these particles have been found in human samples. Laboratory animals exposed to MPs develop inflammation, immunological responses, endocrine disruptions, and alterations in lipid and energy metabolism, among other disorders. MPs additives also demonstrated adverse reactions. There is evidence that MPs and their additives are potential “obesogens” and could participate in NAFLD pathogenesis by modifying gut microbiota composition or even worsen liver fibrosis. Although human exposure to MPs seems clear, their relationship with NAFLD requires further study, since its prevention could be a possible personalized therapeutic strategy. Adequate mitigation strategies worldwide, reducing environmental pollution and human exposure levels of MPs, could reduce the risk of NAFLD.
Exploring the Associations between Social Media Addiction and Depression: Attentional Bias as a Mediator and Socio-Emotional Competence as a Moderator
Authors: Xiao Wen , Peng Jiaxin , Liao Suqun
Published: October 2022

Social media is used daily by a significant number of young people and can have an important influence on the well-being of its users. The aim of this study was to determine the motives for social media use among Chinese youth and whether social media addiction associates with depression. Another objective was to analyze possible mediating and moderating effects in explaining the association between social media addiction and depression. Participants were 1652 secondary school students (51.5% boys and 48.5% girls) aged 12–18 years in China. The results showed that attention bias mediated the association between social media addiction and depression when adolescents’ socio-emotional competencies were low, but not as strong when their socio-emotional competencies were high. The findings not only provided theoretical support for preventing the negative effects of mobile social media addiction, but could also directly contribute to improving adolescents’ quality of life.
Affective Attitudes in the Face of the COVID-19 Pandemic: The Dynamics of Negative Emotions and a Sense of Threat in Poles in the First Wave of the Pandemic
Authors: Szuster Anna , Huflejt-Łukasik Miroslawa , Karwowska Dorota , Pastwa Maciej , Laszczkowska Zuzanna , Imbir Kamil K.
Published: October 2022

For millions of people, the COVID-19 pandemic situation and its accompanying restrictions have been a source of threat and confrontation with negative emotions. The pandemic’s universal and long-term character, as well as the ensuing drastic limitation of control over one’s life, have made it necessary to work out adaptive strategies that would reduce negative experiences and eventually lead to the restoration of well-being. The aim of this research was to identify strategies that people use in response to a long-term threat that restore affective balance and a subjective sense of security. We registered selected manifestations of affective reactions to the pandemic situation. The researchers focused on the dynamics of changes in the areas of (1) experienced negative emotions (asked in an indirect way) and (2) a subjective feeling of threat regarding the pandemic (in three different contexts: Poland, Europe, and worldwide) during the first phase of the pandemic in Poland. It was expected that both the negative emotions and the sense of threat would decrease with time. In addition, it was anticipated that the physical distance would modify the assessment of the situation as threatening depending on the geographical proximity: in Poland, Europe, and worldwide. We used the mixed quasi-experimental design in the series of four studies conducted by Internet in March, May, June, and July 2020. The intensity of negative emotions and the sense of threat caused by the pandemic situation in Poland, Europe, and worldwide were measured. Despite the objective number of confirmed COVID-19 cases during each of the stages of the study, both the intensity of emotions attributed by participants as well as the feeling of threat were found to have decreased. In addition, surprisingly, a reversed effect of the distance was revealed: namely, a sense of threat experienced towards distant locations (Europe and the world) was found to be more acute when compared with the threat experienced in Poland. The obtained results are interpreted as a manifestation of adaptive perception of the threat that lies beyond one’s control, which takes the form of unconscious, biased distortions: unrealistic optimism. The decrease in the intensity of negative emotions explains unrealistic absolute optimism, while the perception of the situation in Poland as less threatening than in Europe and around the world is predicted by unrealistic comparative optimism.
Interaction between Health and Financial Status on Coping Behaviors during the COVID-19 Pandemic
Authors: Yanit Mehmet , Shi Kan , Wan Fang , Gao Fei
Published: October 2022

Background: The year 2022 started with protests against COVID-19 restrictions throughout North America. These events manifest the fact that some segments of the population are not compliant with the preventive measures of COVID-19, and the reasons of the disobedience against public health regulation remain unclear. The current paper examined the joint effect of financial and health status on people’s likelihood of pursuing active coping efforts (i.e., following preventive measures) and giving up coping with the COVID-19 pandemic. Method: We conducted a large-scale survey study in China (N = 3834) in May 2020. Results: Our results showed that people with low financial status were less likely to manifest active coping behavior and more likely to give up coping with the pandemic. People’s self-confidence in coping with the pandemic mediated this effect. We showed that one’s health status could interact with their financial status in a way that healthy people with low financial status would have less confidence in their coping abilities and thus become less likely to pursue active coping efforts and more likely to give up coping with the pandemic. Conclusions: Our results call for policymakers to find more effective solutions for noncompliant groups so that they can abide by the general guidelines in the COVID-19 context and other social crises that may emerge in the future. We suggest that governments should concentrate their support efforts on healthy populations of low financial segments to prevent COVID-19 and other infectious diseases in the future from spreading further.
The Perception and Attitude of Farmers toward Domestic Waste Classifications: A Case Study on Wusheng County, Sichuan Province, China
Authors: Wang Xuxi , Tan Jing
Published: October 2022

The effective treatment of rural domestic waste is the key to solving rural environmental pollution and realizing rural ecological revitalization. Giving full play to the main role of farmers’ domestic waste classification can improve the efficiency and effect of domestic waste treatment. To explore the key factors affecting the farmers’ perception, attitude, and behavior of domestic waste classification, this study with 318 farmers in Sichuan Province as the research object, the research framework of domestic waste classification behavior was constructed based on the theory of planned behavior, and then, the logistic regression model was used for the empirical test. The results show that the farmers’ education levels, subjective norms, relatives’ and neighbors’ views on waste classification, farmers’ awareness regarding the negative environmental impacts caused by waste, farmers’ private benefits, and farmers’ views on the waste management ability of local governments are significantly positively correlated with the classification behavior of farmers’ domestic waste. The distance between farmers’ houses and waste collection points is significantly negatively correlated with the classification behavior of farmers’ domestic waste. This paper provides a certain theoretical reference for realizing the reduction, resourcization, and positive development of rural domestic waste management in China.
The State of the Psychological Contract, Justice and Engagement Drive Nurses’ Performance Behaviors
Authors: Rodwell John , Johnson Dianne
Published: October 2022

This paper investigates the links between the psychological contract and organizational justice variables on to performance behaviors through the mechanisms of engagement, job satisfaction and psychological distress, beyond the perception-oriented individual factor of negative affectivity. Nursing staff (n = 273) from a medium to large Australian hospital completed a self-report survey. Structural equation modeling found differential effects of psychological contract breach and psychological contract status, the mediating roles of engagement, job satisfaction and distress on to performance behaviors, while noting the role of individual negative affectivity. Engaging nurses is critical to both their in-role and discretionary performance behaviors. Reducing negative impacts, particularly those due to breaking promises and unfair processes, while protecting the nurses’ mental health, enables performance levels to be maintained. This study demonstrates that nurses’ general perceptions of their employment relationship impacted their in-role and discretionary performance behaviors, especially through the mechanism of engagement. The complexity of managing nurses is highlighted by those variables that enacted positive impacts via engagement as versus the variables that led to distress and acted as brakes on performance, as well as the impact of the negative affectivity trait of the nurses.
Identification of Prognostic Gene Signatures by Developing a scRNA-Seq-Based Integration Approach to Predict Recurrence and Chemotherapy Benefit in Stage II–III Colorectal Cancer
Authors: Wang Zixuan , Xing Kaiyuan , Zhang Bo , Zhang Yanru , Chai Tengyue , Geng Jingkai , Qin Xuexue , Zhang Xinxin , Xu Chaohan
Published: October 2022

Prospective identification of robust biomarkers related to prognosis and adjuvant chemotherapy has become a necessary and critical step to predict the benefits of adjuvant therapy for patients with stage II–III colorectal cancer (CRC) before clinical treatment. We proposed a single-cell-based prognostic biomarker recognition approach to identify and construct CRC up- and down-regulated prognostic signatures (CUPsig and CDPsig) by integrating scRNA-seq and bulk datasets. We found that most genes in CUPsig and CDPsig were known disease genes, and they had good prognostic abilities in CRC validation datasets. Multivariate analysis confirmed that they were two independent prognostic factors of disease-free survival (DFS). Significantly, CUPsig and CDPsig could effectively predict adjuvant chemotherapy benefits in drug-treated validation datasets. Additionally, they also performed well in patients with CMS4 subtype. Subsequent analysis of drug sensitivity showed that expressions of these two signatures were significantly associated with the sensitivities of CRC cell lines to multiple drugs. In summary, we proposed a novel prognostic biomarker identification approach, which could be used to identify novel prognostic markers for stage II–III CRC patients who will undergo adjuvant chemotherapy and facilitate their further personalized treatments.
Intact Type I Interferon Receptor Signaling Prevents Hepatocellular Necrosis but Not Encephalitis in a Dose-Dependent Manner in Rift Valley Fever Virus Infected Mice
Authors: Michaely Lukas Mathias , Schuwerk Lukas , Allnoch Lisa , Schön Kathleen , Waltl Inken , Larsen Pia-Katharina , Pavlou Andreas , Prajeeth Chittappen Kandiyil , Rimmelzwaan Guus F. , Becker Stefanie C. , Kalinke Ulrich , Baumgärtner Wolfgang , Gerhauser Ingo
Published: October 2022

Rift Valley fever (RVF) is a zoonotic and emerging disease, caused by the RVF virus (RVFV). In ruminants, it leads to “abortion storms” and enhanced mortality rates in young animals, whereas in humans it can cause symptoms like severe hemorrhagic fever or encephalitis. The role of the innate and adaptive immune response in disease initiation and progression is still poorly defined. The present study used the attenuated RVFV strain clone 13 to investigate viral spread, tissue tropism, and histopathological lesions after intranasal infection in C57BL/6 wild type (WT) and type I interferon (IFN-I) receptor I knockout (IFNAR−/−) mice. In WT mice, 104 PFU RVFV (high dose) resulted in a fatal encephalitis, but no hepatitis 7–11 days post infection (dpi), whereas 103 PFU RVFV (low dose) did not cause clinical disease or significant histopathological lesions in liver and the central nervous system (CNS). In contrast, IFNAR−/− mice infected with 103 PFU RVFV developed hepatocellular necrosis resulting in death at 2–5 dpi and lacked encephalitis. These results show that IFNAR signaling prevents systemic spread of the attenuated RVFV strain clone 13, but not the dissemination to the CNS and subsequent fatal disease. Consequently, neurotropic viruses may be able to evade antiviral IFN-I signaling pathways by using the transneuronal instead of the hematogenous route.
Molecular Mechanism of Mouse Uterine Smooth Muscle Regulation on Embryo Implantation
Authors: Cao Rui , Yang Zhen-Shan , Hu Sui-Li , Liang Shi-Jin , Zhang Shu-Miao , Zhu Song-Qi , Lu Lin , Long Cheng-Hong , Yao Si-Tong , Ma Yong-Jiang , Liang Xiao-Huan
Published: October 2022

Myometrium plays critical roles in multiple processes such as embryo spacing through peristalsis during mouse implantation, indicating vital roles of smooth muscle in the successful establishment and quality of implantation. Actin, a key element of cytoskeleton structure, plays an important role in the movement and contraction of smooth muscle cells (SMCs). However, the function of peri-implantation uterine smooth muscle and the regulation mechanism of muscle tension are still unclear. This study focused on the molecular mechanism of actin assembly regulation on implantation in smooth muscle. Phalloidin is a highly selective bicyclic peptide used for staining actin filaments (also known as F-actin). Phalloidin staining showed that F-actin gradually weakened in the CD-1 mouse myometrium from day 1 to day 4 of early pregnancy. More than 3 mice were studied for each group. Jasplakinolide (Jasp) used to inhibit F-actin depolymerization promotes F-actin polymerization in SMCs during implantation window and consequently compromises embryo implantation quality. Transcriptome analysis following Jasp treatment in mouse uterine SMCs reveals significant molecular changes associated with actin assembly. Tagln is involved in the regulation of the cell cytoskeleton and promotes the polymerization of G-actin to F-actin. Our results show that Tagln expression is gradually reduced in mouse uterine myometrium from day 1 to 4 of pregnancy. Furthermore, progesterone inhibits the expression of Tagln through the progesterone receptor. Using siRNA to knock down Tagln in day 3 SMCs, we found that phalloidin staining is decreased, which confirms the critical role of Tagln in F-actin polymerization. In conclusion, our data suggested that decreases in actin assembly in uterine smooth muscle during early pregnancy is critical to optimal embryo implantation. Tagln, a key molecule involved in actin assembly, regulates embryo implantation by controlling F-actin aggregation before implantation, suggesting moderate uterine contractility is conducive to embryo implantation. This study provides new insights into how the mouse uterus increases its flexibility to accommodate implanting embryos in the early stage of pregnancy.
Assessment of Salt Stress to Arabidopsis Based on the Detection of Hydrogen Peroxide Released by Leaves Using an Electrochemical Sensor
Authors: Zhang Jiancheng , Lu Mei , Zhou Han , Du Xihua , Du Xin
Published: October 2022

Salt stress will have a serious inhibitory effect on various metabolic processes of plant cells, this will lead to the excessive accumulation of reactive oxygen species (ROS). Hydrogen peroxide (H2O2) is a type of ROS that can severely damage plant cells in large amounts. Existing methods for assessing the content of H2O2 released from leaves under salt stress will cause irreversible damage to plant leaves and are unable to detect H2O2 production in real time. In this study, on the strength of a series of physiological indicators to verify the occurrence of salt stress, an electrochemical sensor for the detection of H2O2 released from leaves under salt stress was constructed. The sensor was prepared by using multi-walled carbon nanotube-titanium carbide–palladium (MWCNT-Ti3C2Tx-Pd) nanocomposite as substrate material and showed a linear response to H2O2 detection in the range 0.05–18 mM with a detection limit of 3.83 μM. Moreover, we measured the determination of H2O2 released from Arabidopsis leaves at different times of salt stress by the sensor, which was consistent with conventional method. This study demonstrates that electrochemical sensing is a desirable technology for the dynamic determination of H2O2 released by leaves and the assessment of salt stress to plants.
Tool Wear Prediction Based on a Multi-Scale Convolutional Neural Network with Attention Fusion
Authors: Huang Qingqing , Wu Di , Huang Hao , Zhang Yan , Han Yan
Published: October 2022

Compared with traditional machine learning algorithms, the convolutional neural network (CNN) has an excellent automatic feature learning ability and can complete the nonlinear representation from original data input to output by itself. However, the CNN does not sufficiently mine the tool wear information contained in the multi-sensor data due to disregard of the differences in the contribution of different features when extracting features. In this paper, a tool wear prediction method based on a multi-scale convolutional neural network with attention fusion is proposed, which fuses the tool wear degradation information collected by different types of sensors. In the multi-scale convolution module, convolution kernels with different sizes are used to extract the degradation information of different scales in the wear information, and then the attention fusion module is constructed to fuse the multi-scale feature information. Finally, the mapping between tool wear and multi-sensor data is realized through the feature information obtained by residual connection and full connection layer. By comparing the multi-scale convolutional neural network with different attention mechanisms, the experiments demonstrated the effectiveness and superiority of the proposed method.
Edible Insects for Humans and Animals: Nutritional Composition and an Option for Mitigating Environmental Damage
Authors: Ordoñez-Araque Roberto , Quishpillo-Miranda Nadine , Ramos-Guerrero Luis
Published: October 2022

Every day, there is an increase in environmental damage on the planet regarding human action. One of the causes is food production. Edible insects are presented as an option to mitigate the environmental damage generated by the production of conventional food for humans and animals. The objective of this study was to investigate the main nutritional aspects of insects and how they can provide a nutritional and sustainable alternative to the planet. As the main results, the nine orders of insects that are most consumed on the planet are presented: Blattodea, Coleoptera, Diptera, Hemiptera, Hymenoptera, Isoptera, Lepidoptera, Odonata, and Orthoptera. Their main macro- and micronutrient aspects as well as their bioavailable and bioaccessibility proteins and essential amino acids, monounsaturated fatty acids, minerals, vitamins, and fiber (chitin) are also explored. Additionally, some of the species that are used for animal food processing and the possible risks that insects can present when used as food are discussed. With this, edible insects are established as a real option to mitigate climate change being an important nutritional source for the development of food for humans and animals.
Visualization of Peripheral Blood Vessels on the Lingual Aspect of the Mandible Using a Balanced Steady-State Free-Precession Sequence with a Time–Spatial Labeling Inversion Pulse: Usefulness for Prevention of Severe Complications of Dental Implantation
Authors: Tanaka Tatsurou , Kawashima Yusuke , Oda Masafumi , Wakasugi-Sato Nao , Matsumoto-Takeda Shinobu , Nishimura Shun , Morimoto Yasuhiro
Published: October 2022

The aim of this study was to evaluate whether a balanced steady-state free-precession (SSFP) sequence with a time–spatial labeling inversion pulse (time–SLIP) without contrast medium could elucidate branches of the lingual and facial arteries on the lingual aspect of the mandible as a potential technique for preventing severe complications in dental implantation surgery. In this study, magnetic resonance angiography (MRA) using SSFP with a time–SLIP was evaluated in 40 subjects. The outline and course of branches of the lingual and facial arteries near the mandible were assessed clinically in the same subjects against contrast-enhanced computed tomography (CT) images as the gold standard. The submental, sublingual, and deep lingual arteries could be visualized via MRA in 16, 20, and 16 of the 40 subjects, respectively. The major axes of the respective arteries were approximately 24, 24, and 16 mm. The outline and course of all visualized arteries coincided with those on CT. MRA using SSFP with a time–SLIP appears to have potential as a non-contrast technique for visualizing branches of the lingual and facial arteries on the lingual aspect of the mandible. Information regarding the outline and course of these arteries as obtained using this MRA technique could assist in preventing severe complications in dental implantation surgery.
Bruton’s Tyrosine Kinase Inhibitors: The Next Frontier of B-Cell-Targeted Therapies for Cancer, Autoimmune Disorders, and Multiple Sclerosis
Authors: Garg Neeta , Padron Elizabeth Jordan , Rammohan Kottil W. , Goodman Courtney Frances
Published: October 2022

Bruton’s tyrosine kinase (BTK) is an important protein belonging to the tyrosine kinase family that plays a key role in the intracellular signaling and proliferation, migration, and survival of normal and malignant B-lymphocytes and myeloid cells. Understanding the role of BTK in the B-cell signaling pathway has led to the development of BTK inhibitors (BTKi) as effective therapies for malignancies of myeloid origin and exploration as a promising therapeutic option for other cancers. Given its central function in B-cell receptor signaling, inhibition of BTK is an attractive approach for the treatment of a wide variety of autoimmune diseases that involve aberrant B-cell function including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and multiple sclerosis (MS). Here, we review the role of BTK in different cell signaling pathways, the development of BTKi in B-cell malignancies, and their emerging role in the treatment of MS and other autoimmune disorders.
The Value of Fine Needle Aspiration Biopsy in the Pre-Operative Assessment of the Axilla in Breast Cancer Patients
Authors: Raymond Wendy A. , Kleinig Pakan
Published: October 2022

This paper reviews the role of fine needle aspiration biopsy (FNAB) in assessing the axilla prior to definitive surgery or neoadjuvant therapy in breast cancer patients. The radiological criteria for biopsy are discussed and pathological techniques and pitfalls illustrated. The sensitivity and specificity of the technique and the clinical utility are addressed, with particular reference to the current controversies in the management of the axilla in the light of the American College of Surgeons Oncology Group Z0011 trial results. The low morbidity procedure of FNAB is recommended when the radiological and clinical features suggest a high yield from the abnormal axillary nodes, with consideration of core biopsy if an expected positive result is not obtained or the circumstances require tissue for ancillary studies. In conclusion, FNAB of the axilla is a highly sensitive procedure which can offer further valuable information to assist in clinical decision making. The technique is of particular value in the setting of a large primary tumour size and multiple enlarged nodes. A summary flow chart is provided to facilitate pre-operative management of the axilla and to encourage a universal approach.
Supersonic Motion of Atoms in an Octahedral Channel of fcc Copper
Authors: Bayazitov Ayrat M. , Bachurin Dmitry V. , Bebikhov Yuri V. , Korznikova Elena A. , Dmitriev Sergey V.
Published: October 2022

In this work, the mass transfer along an octahedral channel in an fcc copper single crystal is studied for the first time using the method of molecular dynamics. It is found that the initial position of the bombarding atom, outside or inside the crystal, does not noticeably affect the dynamics of its motion. The higher the initial velocity of the bombarding atom, the deeper its penetration into the material. It is found out how the place of entry of the bombarding atom into the channel affects its further dynamics. The greatest penetration depth and the smallest dissipation of kinetic energy occurs when the atom moves exactly in the center of the octahedral channel. The deviation of the bombarding atom from the center of the channel leads to the appearance of other velocity components perpendicular to the initial velocity vector and to an increase in its energy dissipation. Nevertheless, the motion of an atom along the channel is observed even when the entry point deviates from the center of the channel by up to 0.5 Å. The dissipated kinetic energy spent on the excitation of the atoms forming the octahedral channel is nearly proportional to the deviation from the center of the channel. At sufficiently high initial velocities of the bombarding atom, supersonic crowdions are formed, moving along the close-packed direction ⟨1¯10⟩, which is perpendicular to the direction of the channel. The results obtained are useful for understanding the mechanism of mass transfer during ion implantation and similar experimental techniques.
Plasma Functionalization of Multi-Walled Carbon Nanotubes for Ammonia Gas Sensors
Authors: Bannov Alexander G. , Manakhov Anton M. , Shtansky Dmitry V.
Published: October 2022

The role of plasma functionalization of multi-walled carbon nanotubes (MWCNTs) for room-temperature ammonia gas sensors was investigated. Plasma functionalization of MWCNTs with maleic anhydride was carried out at various durations. The active material of the gas sensor was investigated by scanning electron microscopy, transmission electron microscopy, Raman spectroscopy, and X-ray photoelectron spectroscopy. It was shown that the formation of functional groups on the surface of carbon nanotubes led to an increase in the ammonia sensor response by two to four times. The increase in functionalization duration induced the rise of O/C from 0.28 to 0.335, an increase in sensor resistance, and the distortion of the shape of the I-V curves.
Strength Evaluation of Functionalized MWCNT-Reinforced Polymer Nanocomposites Synthesized Using a 3D Mixing Approach
Authors: Patel Vijay , Joshi Unnati , Joshi Anand , Oza Ankit D. , Prakash Chander , Linul Emanoil , Campilho Raul Duarte Salgueiral Gomes , Kumar Sandeep , Saxena Kuldeep Kumar
Published: October 2022

The incorporation of carboxyl functionalized multi-walled carbon nanotube (MWCNT- COOH) into a polymethyl methacrylate (PMMA) has been investigated. The resultant tensile and flexural mechanical properties have been determined. In this paper, a novel synthesis process for a MWCNT-reinforced polymer nanocomposite is proposed. The proposed method significantly eliminates the most challenging issues of the nano-dispersed phase, including agglomeration and non-homogeneous mixing within a given matrix material, and also resolves the issues occurring in conventional mixing processes. The results of scanning electron microscopy support these claims. This 3D-mixing process is followed by an extrusion process, using a twin-screw extruder for pristine MWCNT, and a compression molding process for COOH-MWCNT, to prepare test specimens for experimentally determining the mechanical properties. The test specimens are fabricated using 0.1, 0.5, and 1.0 wt.% MWCNT, with a remaining PMMA phase. The testing is conducted according to ASTM D3039 and ASTM D7264 standards. Significant improvements of 25.41%, 35.85%, and 31.75% in tensile properties and 18.27%, 48%, and 33.33% in flexural properties for 0.1, 0.5, and 1.0 wt.% COOH-MWCNT in PMMA, respectively, compared to non-functionalized MWCNTs, were demonstrated. The highest strength was recorded for the nanocomposite with 0.5 wt.% f-MWCNT content, indicating the best doping effect at a lower concentration of f-MWCNT. The proposed CNT-PMMA nanocomposite may be found suitable for use as a scaffold material in the domain of bone tissue engineering research. This type of research possesses a high strength requirement, which may be fulfilled using MWCNT. Furthermore, this analysis also shows a significant amount of enhancement in flexural strength, which is clinically required for fabricating denture bases.
Ni/(R2O3,CaO) Nanocomposites Produced by the Exsolution of R1.5Ca0.5NiO4 Nickelates (R = Nd, Sm, Eu): Rare Earth Effect on the Catalytic Performance in the Dry Reforming and Partial Oxidation of Methane
Authors: Malyshev Sergey A. , Shlyakhtin Oleg A. , Loktev Alexey S. , Mazo Galina N. , Timofeev Grigoriy M. , Mukhin Igor E. , Svetogorov Roman D. , Roslyakov Ilya V. , Dedov Alexey G.
Published: October 2022

In order to clarify the role of R2O3 in the metal-oxide catalysts derived from complex oxide precursors, a series of R1.5Ca0.5NiO4 (R = Nd, Sm, Eu) complex oxides was obtained. A significant systematic increase in the orthorhombic distortion of the R1.5Ca0.5NiO4 structure (K2NiF4 type, Cmce) from Nd to Eu correlates with a corresponding decrease in their ionic radii. A reduction of R1.5Ca0.5NiO4 in the Ar/H2 gas mixture at 800 °C causes a formation of dense agglomerates of CaO and R2O3 coated with spherical 25–30 nm particles of Ni metal. The size of metal particles and oxide agglomerates is similar in all Ni/(R2O3,CaO) composites in the study. Their morphology is rather similar to the products of redox exsolution obtained by the partial reduction of complex oxides. All obtained composites demonstrated a significant catalytic activity in the dry reforming (DRM) and partial oxidation (POM) of methane at 700–800 °C. A systematic decrease in the DRM catalytic activity of composites from Nd to Eu could be attributed to the basicity reduction of R2O3 components of the composite catalysts. The maximum CH4 conversion in POM reaction was observed for Ni/(Sm2O3,CaO), while the maximum selectivity was demonstrated by Nd2O3-based composite. The possible reasons for the observed difference are discussed.
Approach to Estimate the Phase Formation and the Mechanical Properties of Alloys Processed by Laser Powder Bed Fusion via Casting
Authors: Kühn Uta , Sander Jan , Gabrysiak Katharina Nicole , Giebeler Lars , Kosiba Konrad , Pilz Stefan , Neufeld Kai , Boehm Anne Veronika , Hufenbach Julia Kristin
Published: October 2022

A high-performance tool steel with the nominal composition Fe85Cr4Mo8V2C1 (wt%) was processed by three different manufacturing techniques with rising cooling rates: conventional gravity casting, centrifugal casting and an additive manufacturing process, using laser powder bed fusion (LPBF). The resulting material of all processing routes reveals a microstructure, which is composed of martensite, austenite and carbides. However, comparing the size, the morphology and the weight fraction of the present phases, a significant difference of the gravity cast samples is evident, whereas the centrifugal cast material and the LPBF samples show certain commonalities leading finally to similar mechanical properties. This provides the opportunity to roughly estimate the mechanical properties of the material fabricated by LPBF. The major benefit arises from the required small material quantity and the low resources for the preparation of samples by centrifugal casting in comparison to the additive manufacturing process. Concluding, the present findings demonstrate the high attractiveness of centrifugal casting for the effective material screening and hence development of novel alloys adapted to LPBF-processing.
Benefits of Printed Graphene with Variable Resistance for Flexible and Ecological 5G Band Antennas
Authors: Cherevko Alexander G. , Krygin Alexey S. , Ivanov Artem I. , Soots Regina A. , Antonova Irina V.
Published: October 2022

The possibility of creating antennas of the 5G standard (5.2–5.9 GHz) with specified electrodynamic characteristics by printing layers of variable thickness using a graphene suspension has been substantiated experimentally and by computer simulation. A graphene suspension for screen printing on photographic paper and other flexible substrates was prepared by means of exfoliation from graphite. The relation between the graphene layer thickness and its sheet resistance was studied with the aim of determining the required thickness of the antenna conductive layer. To create a two-sided dipole, a technology has been developed for the double-sided deposition of graphene layers on photographic paper. The electrodynamic characteristics of graphene and copper antennas of identical design are compared. The antenna design corresponds to the operating frequency of 2.4 GHz. It was found that the use of graphene as a conductive layer made it possible to suppress the fundamental (first) harmonic (2.45 GHz) and to observe radiation at the second harmonic (5.75 GHz). This effect is assumed to observe in the case when the thickness of graphene is lower than that of the skin depth. The result indicates the possibility of changing the antenna electrodynamic characteristics by adjusting the graphene layer thickness.
Non-Destructive Methods and Numerical Analysis Used for Monitoring and Analysis of Fibre Concrete Deformations
Authors: Adamczak-Bugno Anna , Lipiec Sebastian , Vavruš Martin , Koteš Peter
Published: October 2022

The aim of the research was to check the possibility of using the non-destructive method of acoustic emission to assess the condition of concrete without dispersed reinforcement and with various additions of curved steel fibres, during three-point bending. An important aspect of the research proposed in the article is the use of a hybrid method of analysis, which involves complementing the results of strength tests, the results of numerical calculations and the results of strain distributions recorded with a digital image correlation system (DIC System, in this research GOM Suite optical system). The operation of the concrete material under load, depending on the amount of fibres added, is reflected in the recorded acoustic emission (AE) signals. The differences concern the number of signals of individual classes and their distribution over time. The differences exist for both low and high load values, which confirms the possibility of using the acoustic emission method to monitor the condition of the material. It was shown that the numerically determined effective stress levels decreased as the proportion of steel fibres in the concrete increased, while the maximum levels of the first principal stresses increased. During the analyses, a preliminary comparison of the deformation results obtained using the finite element method and the DIC System was also carried out.