bluuebunny/crossref_metadata_2025 huggingface dataset:
THE CONNECTION OF LOCAL RETINAL DETACHMENT IN THE MACULAR AREA WITH THE FOSSA OF THE OPTIC DISC. DIFFERENTIAL DIAGNOSIS (CLINICAL CASE)
Authors: Telyatov B. A. , Barishev K. V.
Published: November 2024

Relevance. The optic nerve pit is a congenital disease manifested by a depression in the disc of the optic nerve, which affects about 0.9% of the population. Complications occur in 25–75% of patients and may include retinal detachment. The causes of detachment remain unclear, but two theories of the occurrence of this complication have been put forward. Fluorescence angiography and optical coherence tomography are used for diagnosis. The treatment of retinal detachment in ONDP is not standardized and includes laser treatment, vitrectomy and other methods for fluid drainage. It is important to differentiate ONDP from other causes of central retinal detachment.

Objective. Based on a clinical case, to demonstrate an approach to the diagnosis and treatment of local retinal detachment in the macular area associated with the fossa of the optic disc.

Materials and methods. This article presents a clinical case of retinal detachment in the macular area associated with the fossa of the optic disc. Results and discussions. When comparing two clinical cases, the similarity of the ophthalmoscopic picture and the differences in the OCT and FAG images were revealed.

Conclusions. The accumulation of fluid under the neuroepithelium is not a pathognomic sign, therefore it is important to carry out differential diagnosis in central serous retinal detachment associated with the fossa of the optic disc.
THE IMPORTANCE OF REMOVING THE INNER BOUNDARY MEMBRANE IN THE TREATMENT OF DIABETIC MACULAR EDEMA: A SERIES OF CLINICAL CASES
Authors: Telyatov B. A. , Balkar S. Sh.
Published: November 2024

Vitreoretinal surgery (VRH) is recognized as the preferred method of treating diabetic macular edema (DMO), concomitant with additional pathology of the vitreomacular interface (VMI). Empirical data obtained as a result of numerous studies give contradictory results, therefore, the need for peeling of the internal limiting membrane (VPM) remains unresolved.

Purpose. To find out the results of surgical intervention in patients with DMO as a result of epimacular fibrosis (EMF) by comparing cases with and without HPV peeling.

Materials and methods. This manuscript presents a comparative assessment of three clinical cases. The patients had similar clinical manifestations and historical medical data. In all cases, patients underwent HRH for DMO combined with EMF. In two cases, the VPM was peeled, and in the third case, the VPM was preserved.

Results. An analysis of the observational data and an assessment of anatomical and functional parameters revealed complications in the first and second patients at the late postoperative stage, while in the third patient the condition stabilized. Conclusion. The presented clinical cases show that anatomical and functional results are not always correlated. The increased risk of complications associated with a violation of the architecture and functionality of the retina during peeling requires a critical assessment of the clinical justification of this method.
Instruction set and language for chemical nomenclature
Authors: López-Rubio Ezequiel
Published: November 2024

Processing of chemical information by computational intelligence methods faces the challenge of the structural complexity of molecular graphs. These graphs are not amenable to being represented in a suitable way for such methods. The most popular representation is the SMILES notation standard. However, it comes with some limitations such as the abundance of non-valid strings and the fact that similar strings often represent very different molecules. In this work, a completely different approach to chemical nomenclature is presented. A reduced instruction set is defined, and the language of all strings that are sequences of such instructions is considered. All strings of this language are valid, i.e., each string represents a molecule. Moreover, slight changes in a string usually correspond to small modifications in the represented molecule. Therefore, this approach is appropriate for its use if state-of-the-art computational intelligence systems for chemical information processing, including deep learning models.
Polariton Spectra under the Collective Coupling Regime. II. 2D Non-linear Spectra
Authors: Mondal M. Elious , Vamivakas A. Nickolas , Cundiff Steven , Krauss Todd , Huo Pengfei
Published: November 2024

In our previous work [Ref.~\citenum{MondalJCP2024paper1}], we developed several efficient strategies to simulate exciton-polariton dynamics described by the Holestein-Tavis-Cummings (HTC) Hamiltonian under the collective coupling regime. Here, we incorporated these strategies into the previously developed $\mathcal{L}$-PLDM approach for simulating 2D Electronic Spectroscopy (2DES) spectra of exciton-polariton under the collective coupling regime. In particular, we apply the efficient quantum dynamics propagation scheme developed in Paper I to both the forward and the backward propagations in the PLDM, and develop an efficient important sampling scheme and GPU vectorization scheme that allow us to reduce the computational costs from $\mathcal{O}(\mathcal{K}^2)\mathcal{O}(T^3)$ to $\mathcal{O}(\mathcal{K}) \mathcal{O}(T^0)$ for the 2DES spectra simulation, where $\mathcal{K}$ is the number of states and $T$ is the number of time steps of propagation. We further simulated the 2DES spectra for an HTC Hamiltonian under the collective coupling regime and analyzed the signal from both rephasing and non-rephasing contributions of the ground state bleaching (GSB), excited state emission (ESA), and stimulated emission (SE) pathways.
Robust Protein-Ligand Interaction Modeling Integrating Physical Laws and Geometric Knowledge for Absolute Binding Free Energy Calculation
Authors: Su Qun , Wang Jike , Gou Qiaolin , Hu Renling , Zhang Hui , Jiang Linlong , Wang Tianyue , Liu Yifei , Shen Chao , Kang Yu , Hsieh Chang-Yu , Hou Tingjun
Published: November 2024

Accurate estimation of protein-ligand (PL) binding free energies is a crucial task in medicinal chemistry and a critical measure of PL interaction modeling effectiveness. However, traditional computational methods are often computationally expensive and prone to errors. Recently, deep learning (DL)-based approaches for predicting PL interactions have gained enormous attention, but their accuracy and generalizability are hindered by data scarcity. In this study, we propose LumiNet, a versatile PL interaction modeling framework that bridges the gap between physics-based models and black-box algorithms. LumiNet utilizes subgraph transformer to extract multiscale information from molecular graphs and employs geometric neural networks to integrate PL information, mapping atomic pair structures into key physical parameters of non-bonded interactions in classical force fields, thereby enhancing accurate absolute binding free energy (ABFE) calculations. LumiNet is designed to be highly interpretable, offering detailed insights into atomic interactions within protein-ligand complexes, pinpointing relatively important atom pairs or groups. Our semi-supervised learning strategy enables LumiNet to adapt to new targets with fewer data points than other data-driven methods, making it more relevant for real-world drug discovery. Benchmarks show that LumiNet outperforms the current state-of-the-art model by 18.5% on the PDE10A dataset, and rivals the FEP+ method in some tests with a speed improvement of several orders of magnitude. We applied LumiNet in the scaffold hopping process, which accurately guided the discovery of the optimal ligands. furthermore, we provide a web service for the research community to test LumiNet. The visualization of predicted inter-molecular energy contributions is expected to provide practical values in drug discovery projects.
Site-selective Aryne Formation from Aryl Sulfonium Salts En-abled by Intramolecular Functional Group Translocation.
Authors: Deng Lu , Xiao Bo , Zhou Meng , cao hairong , Sun Tian-Yu , dong zhe
Published: November 2024

Recent advantages in the field of aryl sulfonium salts made these salts readily avaible in one chemical step from common functional groups. A new class of aryl sulfonium salts was developed to improve the site-selectivity of the aryne formation via deprotonation/elimination sequence. Mechanism study revealed an intramolecular aryne translaoction pathway enabled by the reversible proton transfer. Current method could enable late stage (hetero)aryne formation on the pharmaceuticals and greatly reduce the synthetic effort to access structurally highly diversed (hetero)aryne. Mild condition and broad scope pro-vide orthogonal reactivity compared with Kobayashi aryne precursors.
Substituted Cyclopropanols via Sequential Cyclopropanation and Oxidative Hydrolysis of Vinylboronates
Authors: Shuvakin Serhii , Serhieiev Oleksii , Dashko Maksym , Pendiukh Viacheslav , Ivonin Sergey , Shyshkina Svetlana , Rozhenko Alexander , Pashenko Olexandr , Ryabukhin Serhiy , Volochnyuk Dmytro
Published: November 2024

We present a scalable, diastereoselective protocol for synthesizing cyclopropanols, including rare 2-substituted ones, via oxidative hydrolysis of cyclopropyl boron pinacolates. Our previous protocol for Pd-catalyzed cyclopropanation of vinyl boron pinacolates was adapted for flow conditions, allowing safe, scalable utilization of diazomethane and ensuring high yields of target products. The use of ethyldiazoacetate for cyclopropanation allows the formation of boronic acids in the first step; however, decreases the stability of cyclopropanols in the second, yielding esteraldehydes.
Revealing the Role of Local Octahedral Distortions in Hybrid Halide Perovskites Through Physical-Informed Data-Driven Machine Learning
Authors: Chen Xian , Chen Zhe-Ning , Wu Tianmin , Chen Jun
Published: November 2024

Data-driven materials design often encounters challenges from small and imbalanced datasets. The complex structural and physicochemical properties of hybrid halide perovskites, coupled with these limitations, create obstacles for performing feature engineering and extracting key fingerprints. Herein, we employed a physical-informed data-driven modeling approach to identify lattice geometric fingerprints, such as the distortion index (DI) and effective coordination number (ECoN), and to establish a robust structure-properties relationship mapping the electronic bandgap, resulting in improved model performance. Lattice compression simulations across multiple phases of MAPbI3 further confirmed a strong correlation between DI and ECoN with electronic bandgap, validating the robustness of the selected octahedra geometrical fingerprints. By adjusting the s-p antibonding coupling, the pressure-driven reduction in local octahedral distortion, induced by the anisotropic hydrogen bonding between the inorganic framework and organic cation, narrows the electronic bandgap and facilitates the p-p transitions, thereby boosting the transition dipole moment and band-edge absorption. Combining data mining with physical analysis, we have successfully clarified the significant impact of lattice geometry on the electronic properties and identified key octahedral geometric fingerprints for effectively describing the electronic bandgap, while also revealed the microphysical mechanisms of local octahedral distortion on the optoelectronic properties of hybrid halide perovskites.
Tuning Hydrogen Bond Networks at Gold Electrodes: A Study of Potential-Dependent DMSO-Water Interfaces
Authors: Al-Mualem Ziareena , Cardenas Alfredo , Hazarika Sulagna , Ren Hang , Baiz Carlos
Published: November 2024

Understanding the behavior of hydrogen bond (H-bond) networks at electrode interfaces is the first step towards optimizing electrochemical processes. This study investigates the potential-dependent interfacial environment of dimethyl sulfoxide (DMSO)‒water mixtures at gold electrodes using a combination of surface-enhanced infrared absorption spectroscopy (SEIRAS) and constant potential molecular dynamics (MD) simulations. SEIRAS provides in situ spectroscopic data on H¬¬ bonding populations and cosolvent enrichment at the interface, while MD simulations offer an atomistic view of H bond configurations and molecular orientations under applied potentials. Our results demonstrate that applied electrostatic potential influences the interfacial H¬¬ bonding environment. Negative potentials produce enrichment of DMSO and a reorientation of interfacial water molecules, which leads to a slight increase in H-bonded populations, particularly at lower DMSO concentrations. Conversely, positive potentials show a reduced impact on the H bond structure. The effects are different at higher DMSO concentrations where DMSO‒DMSO interactions dominate. Despite DMSO being electrically neutral, both experimental and simulation data reveal a measurable modulation of interfacial enrichment and H¬¬ bond populations as a function of potential.
Looking at High-Pressure Electrides Through the Lens of Quantum Crystallography: The Case of Simple Cubic Calcium
Authors: Racioppi Stefano , Zurek Eva
Published: November 2024

High-pressure electrides (HPEs) represent a unique class of materials characterized by the localization of electrons in non-bonding interstitial regions, distinct from typical atom-atom interactions. This study delves into the properties of calcium in its simple cubic (sc) phase (Ca-sc) under extreme pressure, a candidate for exhibiting HPE behavior. Through quantum crystallography (QCr), we meticulously analyze the electron density and bonding nature of Ca-sc at pressures up to 40 GPa. Our theoretical framework reveals a pressure-induced electronic transition from s- to d-character, resulting in the formation of multi-center bonds (MCBs) within Ca8 clusters. The topological analysis corroborates the existence of non-nuclear maxima (NNM) and electron localization features indicative of HPEs. These findings underscore the efficacy of QCr techniques in elucidating material behavior under extreme conditions, thereby establishing a pathway for experimental validation of HPEs like Ca-sc.
Plánovanie a postupy navigačných letov VFR
Authors:   University of Žilina, Legiň Jakub , Chodelka Frederik
Published: November 2024

Flying according to the visual flight rules is one of the fundamental requirements for every pilot license applicant. VFR cross-country flights combine the main principles of aviation practice, which a pilot needs to master during initial flight training. These principles encompass elements of piloting, navigation, and communication. The aim of this article is to present the basic legislative requirements related to VFR cross-country flights, including Rules of the Air defined by European regulations and the Aeronautical Information Services of the Slovak Republic. The article also describes the procedures for planning VFR cross-country flights, as well as innovative tools designed for flight planning and monitoring.
Návrh hybridnej pohonnej jednotky pre experimentálny letún Straton D7
Authors:   University of Žilina, Longauer Oliver , Čerňan Jozef
Published: November 2024

The aim of this article is designing hybrid power unit for the needs of experimental aircraft Straton D7. Article describes different options of hybridization of power units on basis of their architecture and the function of electric component in relation to the whole power unit. Compares different designs of automotive and aircraft solutions of hybridization of power units. After that, article offers solution for hybrid engine of Straton D7 on basis of gained theoretical knowledge, comparison of shown conceptions and basic calculations, with the needs and predispostion of the original aircraft in its best interest.
Analýza palubného vybavenia moderných lietadiel
Authors:   University of Žilina, Mikolaj Martin , Novák Andrej
Published: November 2024

This bachelor's thesis provides a detailed overview of the development, history and current status of aircraft on-board equipment. The first part deals with the evolution of cockpits from their origins to modern technological trends and future challenges. The next part analyzes the standards, recommendations and certification processes, with an emphasis on the ergonomics of the cockpit design and the requirements of the international organization for civil aviation. The following section addresses pilot adaptation to new cockpit systems, taking into account factors such as human factors, training and automation risks. In the end, current trends, perspectives of future development and their possible impact on pilots and flight safety are evaluated.
Výber vhodného výcviku pre budúcich dopravných pilotov
Authors:   University of Žilina, Vasiľ Martin , Jůn František
Published: November 2024

The bachelor's thesis addresses a critical area of flight training programs that are essential in shaping the capabilities of new pilots in an era of increasing demands on pilots due to technological advances and global connectivity. The study addresses the components of flight training, from theoretical knowledge to practical flight experience, with an emphasis on the design of SPA/IR curricula adapted to the specific requirements and needs of aerotaxi operators. Through a systematic analysis and comparison of existing SPA/IR training curricula and programmes, the thesis highlights the strengths, limitations and potential developments in pilot training to meet industry requirements. The findings aim to improve the safety, efficiency and adaptability of pilots, and a transition to more specialised licensing is proposed to mitigate the risks associated with inexperienced pilots.
Analýza monitorovania motorových prístrojov a činnosti pilota počas letov ifr
Authors:   University of Žilina, Farský Jakub , Chodelka Frederik
Published: November 2024

For safe flight, it is necessary for the pilot to be able to correctly divide his attention during flight between primary and secondary controls. An important part of this is a proper familiarisation with the aircraft and pre-flight preparation. Within this article, the equipment of the aircraft used for training at LVVC during IFR flights is presented in terms of the display of the engine instruments. The analysis of the activities reveals possible in-flight hazards that may affect the pilot's situational awareness during the execution of the flight. Observations on the simulator are used to determine the current state of situational awareness among the pilots in training and to address the problem encountered. The contribution of this thesis is the proposal of the application of scanflow to the monitoring of engine instruments and such measures that could help to increase situational awareness and thereby ensure a higher level of safety during the performance of flight activities.
Effects of different starches on the physicochemical and sensory characteristics
of extruded fish snacks
Authors: Abu Talib A. , Russly A.R. , Bakar J. , Mahmud Ab. Rashid N.K. , Ashari R. , Shukri R. , Wan Ibadullah W.Z. , Mustapha N.A. , M.R. Ismail-Fitry , Z.A. Nur Hanani
Published: November 2024

The market for snack foods is currently heading for healthier choices. Extrusion-based
snacks made of starch are widespread but less nutrient-dense. Therefore, an effort to
produce expanded snacks with higher protein was attempted. However, the physical
properties of high protein extrudates are less desirable. Hence, different kind of starches
were used in attempt to improve the physical properties of extrudates with high protein
from scad fish. The objective of this study was to determine the effect of types and
percentages of three starches, namely tapioca, sago and corn (50, 67, 75% db); on the
physicochemical properties of extrudates from round scad fish powder (Decaptus
madruasi). The formulations were extruded using a single screw extruder with a 3 mm
circular die. The feeder and screw speed were maintained at 150 and 50 rpm, respectively.
The barrel temperatures for each zone were 80°C (zone 1), 120°C (zone 2), 140°C (zone
3) and 160°C (zone 4). The results of the study revealed that all starch types at 75%
increased the expansion ratio of extrudates to 47-56% compared with the inclusion of
starches at 50%. All starch types at 75% also decreased the bulk density to 21-24% and
hardness to 23-50% as compared to extrudates with the lowest amount of starch. The
improvements in the physical properties were more prominent in the addition of tapioca
starch. The highest amount of protein was found in extrudates with tapioca starch (20.8 to
30.4%). The sensory analysis and colour indicated similar results for all extrudates. The
best formulation for the production of fish snacks was extrudates with 75% tapioca starch
and 25% fish powder. The finding of this study is relevant and applicable in the
production of high protein extrudates for children or health-conscious consumers, with the
usage of tapioca starch to assist better expansion that improves the physical properties
Quality enhancement of potato chips through acrylamide mitigation and comparison with local potato chips in Bangladesh
Authors: Nahid M. , Akther S. , Hassan M.K. , Uddin M.N. , Zaber M.A. , Bhuiyan M.N.I.
Published: November 2024

Potato chips are popular and frequently consumed ready-to-eat food in the world.
Acrylamide is a possible carcinogenic and neurotoxic compound formed in potato chips
during heat processing, a public health concern. This study aimed to develop potato chips
to mitigate acrylamide formation, followed by Food and Drug Administration (FDA)
guidelines with some modifications. A total of 15 local chip samples were collected by a
stratified random sampling method and were assessed for nutritional values, sensory
attributes, microbial quality, and acrylamide levels. Acrylamide was extracted from potato
chips using a novel activated charcoal method, then determined by the High- Performance
Liquid Chromatography (HPLC) method and showed that only 40% of local potato chips
were above the benchmark level established by the EU 2017/2158 (750 ppb) (parts per
billion) and ranged from 461 ppb to 2129 ppb while in the developed chips it was not
detected. The microbial results showed that the developed chips are safe according to
Bangladesh Standards and Testing Institution (BSTI) standard, while the local chips
contain total viable count (TVC) (>104
) and yeast-mold count in a significant amount
(>103
). Sensory evaluation results showed that the developed potato chip samples had
high ratings for all the evaluated attributes. From the nutritional point of view, fat content
is lower while protein and fiber content is higher in developed potato chips. Moisture
content is significantly higher in local potato chips than in developed potato chips, which
is the major concern for microbial quality. As a result of the study's findings, acrylamide
formation in potato chips was successfully mitigated by adhering to FDA modification
guidelines without compromising quality, despite the fact that many locally produced
potato chips are unfit for human consumption.
Effect of kefir grain concentration on rheological, microbiological, and
physicochemical characteristics of bovine colostrum kefir
Authors: Rizqiati H. , Febrisiantosa A. , Wahyuningsih R. , Insyira V.R.
Published: November 2024

Bovine colostrum has high nutrition content such as protein, fat, peptide, micro-nutrients,
antimicrobial components and bioactive compounds that benefit the body. Kefir is one
way of diversifying food products as fermented beverage products to increase the
utilization and functional properties of bovine colostrum, which has a unique taste.
Production of colostrum kefir requires the right concentration of kefir grains to obtain
high-quality characteristics. Evaluating the effect of kefir grain concentration on the
rheological, microbiological, and physicochemical characteristics of bovine colostrum
kefir was the purpose of this research. This study used one factorial design with the
variation of kefir grain concentrations 10% (T1), 20% (T2), and 30% (T3) (w/v) with
seven replications. Rheological analysis was conducted, followed by total lactic acid
bacteria, yeast, microbes, protein, fat, ash, water content, carbohydrate, pH, total dissolved
solids and alcohol content. Based on the result, different kefir grain concentrations
significantly decreased total LAB, yeast, microbes, protein, ash, pH, and total dissolved
solids but increased carbohydrate and water content with the addition of kefir grain
concentration. Rheology behavior, fats, and alcohol content had no significant difference.
Treatment of 10% of kefir grain concentration is the most suitable as it contains the
highest total LAB and yeast.
EFFECTIVELY CONNECTING BATTERIES TO ENERGY SYSTEMS FOR THE DIY ENTHUSIAST
Authors: Hertzog P. E.
Published: November 2024

The proliferation of non-expensive commercially available renewable energy systems along with the regular interruption of electrical energy from local power producers has resulted in more DIY (do-it-yourself) enthusiasts. Many of these enthusiasts are from the lower to middle-income classes and thus seek to empower themselves to purchase and install a basic off-grid renewable energy system. It's crucial to emphasize the significance of acquiring a wiring certificate for the electrical setup. National standards, quality management, and human lives are all at risk, so this step cannot be overlooked. However, several components need to be connected in the most efficient and effective way, thereby promoting safety and efficiency. The purpose of this study is to evaluate different electrical connections between two of the main components, the battery (storage device) and the solar charger (or an inverter) to enable an informed decision regarding the optimal type of connection. An experimental setup is used to gather empirical data for seven different electrical connections. The worst type of connection is a solid 1,5 mm cable with battery clamps (or clips) that results in a higher voltage drop of 0,42 V when compared to the ideal type of connection that is a solid 2,5 mm cable with unsoldered crimped lugs. It is recommended that every DIY enthusiast working with electrical connections purchase a non-expensive crimping tool to effectively connect lugs to the correct wire diameter required for their application.
ADVANCEMENTS IN 3D PRINTING FOR METAL BIO-IMPLANTS: A COMPREHENSIVE BIBLIOMETRIC AND SCIENTOMETRIC ANALYSIS
Authors: Banothu Devika , Kumar Pankaj , Reddy Rajasri
Published: November 2024

The growth trend and increasing global population are leading to new healthcare challenges that require prompt and effective solutions to meet the clinical demands. Currently, three-dimensional (3D) printing is emerging as a rapidly advancing technology to produce metal implants and other biomedical applications. This method creates intricate designs with biomimetic characteristics in a shorter timeframe, enabling healthcare providers to meet the needs of their patients better. This study thoroughly analyzes the demand and manufacturing methods for biomedical implants, particularly metal bio-implants. It also delves into biomaterials used in additive manufacturing, accompanied by a comprehensive bibliometric study covering scientific production by country, highly cited nations, productive authors, collaboration networks, and source rankings. The paper further investigates top author contributions, affiliations, and trends, featuring various analytical tools, such as co-citation networks, keyword co-occurrence analysis, and reference publication year spectroscopy, culminating in presenting key findings through insightful field plots. The current study uses network analysis and scientometric methodologies to analyze data taken from the Scopus journal database, which includes articles from the period between 2014 and 2023, to accomplish this goal. Through this analysis, the article aims to offer valuable insights into the relevance and real-world implications of previous research on the additive manufacturing of metal bio-implants.
ROLE OF VACCINATION ON THE CO-INFECTION MODEL WITH COVID-19 ASSOCIATED WITH DIABETES
Authors: Abdul Hye Md. , Ali Biswas Md.Haider , Forhad Uddin Mohammed
Published: November 2024

COVID-19 infection is particularly dangerous for individuals with comorbidities such as kidney disease and diabetes due to weakened immunity. While the pandemic has impacted people of all ages and socioeconomic backgrounds, those with underlying medical conditions are more susceptible to severe outcomes. However, the role of vaccination in the co-infection dynamics of COVID-19 among diabetic patients is not well-represented in the literature. This study examines the unique challenges presented by the co-infection of COVID-19 in individuals with diabetes, focusing on disease transmission dynamics. We employ a mathematical modeling approach using a seven-compartment model that incorporates vaccination and comorbidities like diabetes to analyze the dynamics of COVID-19 outbreaks. Analytical investigations were conducted to demonstrate the solutions' existence, boundedness, positivity, and sensitivity. After calculating the basic reproduction number, we performed a stability analysis of the model's equilibrium points. Our findings indicate that when the reproduction number is less than unity, the disease-free equilibrium is both locally and globally stable. Furthermore, as the vaccination rate increases, the incidence of COVID-19 and its co-infections with diabetes decreases. These results suggest that effective disease treatment strategies should consider the potential impact of vaccination on the co-infection of COVID-19 in diabetic patients.
Self-Creation of Other-Than-Human Identities: A Netnographic Analysis of Identity Labels in the Alterhuman Community on Tumblr
Authors:   Adam Mickiewicz University in Poznań, Ziemna Joanna
Published: November 2024

The paper discusses the alterhuman community composed of individuals who, despite having human bodies, identify as other-than-human. Such identities range from earthly animals to mythological or otherworldly beings such as elves, dragons, aliens or angels, or even immaterial ideas. While alterhumanity is not inherently an online phenomenon, the community is based mainly online, which allows them to discover labels that describe their identities and discuss their lived experience with non-humanity. The paper is based on a project completed in 2021. This research explores the phenomenon of alterhuman identity, including but not limited to otherkin, therian or plurals, focusing on non-human identities. The study looked at the ways in which members of this community produce and use labels which aid in categorizing one’s experience. Through observational netnography with elements of content analysis of existing data gathered from identity labels included in self-introductions on 200 Tumblr blogs, the paper examines the relationship between identifying as alterhuman and being part of (other) social minorities.
Chest pain during a daily run unfolds an unfortunate diagnosis: A case report and review of the literature on spontaneous coronary artery dissection
Authors: Wagle Laxman , Pokharel Kishor , Sapkota Surendra , Shihab Nahla , Regmi Dhiraj Raj , Shrestha Suraj , Doran Jesse
Published: November 2024

Spontaneous coronary artery dissection (SCAD) is an uncommon but important cause of acute coronary syndrome. This condition is not linked to typical atherosclerotic risk factors, such as tobacco use, high blood pressure, diabetes, and hyperlipidemia. The majority of patients with SCAD experience chest pain and have some form of acute coronary syndrome with acute ST-elevation myocardial infarction (STEMI) being the most common. Early diagnosis is of utmost importance, as it can be fatal if management is delayed. Medical management is preferred over percutaneous intervention for hemodynamically stable cases. A case is presented of a 51-year-old female patient with no significant comorbidities who presented with exertional chest pain and STEMI, which unfolded a diagnosis of SCAD.
Re‐evaluation of saccharin and its sodium, potassium and calcium salts (E 954) as food additives
Authors:   EFSA Panel on Food Additives and Flavourings (FAF), Castle Laurence , Andreassen Monica , Aquilina Gabriele , Bastos Maria Lourdes , Boon Polly , Fallico Biagio , FitzGerald Reginald , Frutos Fernandez Maria Jose , Grasl‐Kraupp Bettina , Gundert‐Remy Ursula , Gürtler Rainer , Houdeau Eric , Kurek Marcin , Louro Henriqueta , Morales Patricia , Passamonti Sabina , Batke Monika , Bruzell Ellen , Chipman James , Cheyns Karlien , Crebelli Riccardo , Fortes Cristina , Fürst Peter , Halldorsson Thorhallur , LeBlanc Jean‐Charles , Mirat Manuela , Lindtner Oliver , Mortensen Alicja , Ntzani Evangelia , Shah Romina , Wallace Heather , Wright Matthew , Barmaz Stefania , Civitella Consuelo , Georgelova Petra , Lodi Federica , Mazzoli Elena , Rasinger Josef , Maria Rincon Ana , Tard Alexandra , Zakidou Panagiota , Younes Maged
Published: November 2024

Abstract
This opinion deals with the re‐evaluation of saccharin and its sodium, potassium and calcium salts (E 954) as food additives. Saccharin is the chemically manufactured compound 1,2‐benzisothiazol‐3(2H)‐one‐1,1‐dioxide. Along with its sodium (Na), potassium (K) and calcium (Ca) salts, they are authorised as sweeteners (E 954). E 954 can be produced by two manufacturing methods i.e. Remsen‐Fahlberg and Maumee. No analytical data on potential impurities were provided for products manufactured with the Maumee process; therefore, the Panel could only evaluate saccharins (E 954) manufactured with the Remsen‐Fahlberg process. The Panel concluded that the newly available studies do not raise a concern for genotoxicity of E 954 and the saccharins impurities associated with the Remsen‐Fahlberg manufacturing process. For the potential impurities associated with the Maumee process, a concern for genotoxicity was identified. The data set evaluated consisted of animals and human studies. The Panel considered appropriate to set a numerical acceptable daily intake (ADI) and considered the decrease in body weight in animal studies as the relevant endpoint for the derivation of a reference point. An ADI of 9 mg/kg body weight (bw) per day, expressed as free imide, was derived for saccharins (E 954). This ADI replaces the ADI of 5 mg /kg bw per day (expressed as sodium saccharin, corresponding to 3.8 mg /kg bw per day saccharin as free imide) established by the Scientific Committee on Food. The Panel considered the refined brand‐loyal exposure assessment scenario the most appropriate exposure scenario for the risk assessment. The Panel noted that the P95 exposure estimates for chronic exposure to saccharins (E 954) were below the ADI. The Panel recommended the European Commission to consider the revision of the EU specifications of saccharin and its sodium, potassium and calcium salts (E 954).
THE RIGHT TO WEAR HIJAB: CONSTITUTIONAL ANALYSIS OF FREEDOM OF RELIGION AND EQUALITY
Authors: Sinha Anju
Published: November 2024

The right to wear the hijab has been at the center of law and social debates, especially in light of constitutional rights to religious freedom and equal rights.  While people argue about the idea of secularism and how it should be interpreted in different law settings, the principle of equality, which says that no one should be treated differently because of their religion, is at the heart of this argument. The study stresses how hard it is to balance religious freedom with secular policies that try to make public spaces more uniform, especially in multicultural and diverse countries.  The Karnataka High Court ruled that wearing the hijab is not an essential religious practice for Muslim women and upheld the State's authority to prescribe dress codes in government educational institutions, considering it a reasonable restriction under Articles 19(1)(a) and 21 of the Constitution which is a setback that takes away women's right to "freedom of choice, individual autonomy or freedom of conscience, and freedom of religion."  This is despite the fact that India's Constitutional courts have made many decisions in favor of women's rights. In the controversial decision, it was said that wearing the Hijab is not a required religious practice in Islam. There are still a lot of problems that need to be fixed when looking at the issue of "freedom of conscience" under Article 25 of the Constitution.
पं० जगन्नाथ के लोक साहित्य में सामाजिक मूल्य
Authors: Navita  , Sharmila
Published: November 2024

सामाजिक मूल्य वे सिद्धांत हैं जो किसी भी समाज में लोगों के व्यवहार और क्रियाओं को नियंत्रित करते हैं। ये मूल्य सामाजिक व्यवहार, संवेदनशीलता और पारस्परिक सम्मान पर आधारित होते हैं और एक सुव्यवस्थित समाज का निर्माण करते हैं। प्रमुख सामाजिक मूल्यों में दूसरों के प्रति सम्मान रखना, परस्पर विचारों को आदर देना, सहयोग, सच्चाई, ईमानदारी, सबके प्रति न्याय, समानता का व्यवहार, दूसरों के प्रति दया, अपने कर्त्तव्यों को निभाने का भाव और समाज में सद्भावना बनाए रखना शामिल हैं। ये मूल्य समाज में एकता, सुख और शांति का संचार करते हैं और लोगों को एक-दूसरे के प्रति जिम्मेदार और संवेदनशील बनाते हैं। प्रस्तुत शोध पत्र में पं० जगन्नाथ के लोक साहित्य में निहित सामाजिक मूल्यों का वर्णन किया गया है। पंडित जगन्नाथ हरियाणा के एक प्रसिद्ध लोक कवि और गायक थे। पं० जगन्नाथ के लोक साहित्य में सामाजिक मूल्यों का विशेष स्थान है जो समाज में नैतिकता, कर्त्तव्यपालन, सांस्कृतिक धरोहर के संरक्षण और समानता के सिद्धांतों को बल देते हैं। उनके लोक साहित्य का उद्देश्य समाज में नैतिकता और एकता की भावना का प्रचार करना है। पं० जगन्नाथ के साहित्य में समाज के विभिन्न पहलुओं को छूने वाले मूल्य अत्यंत गहनता से प्रस्तुत किए गए हैं। उनके लेखन में सामूहिकता, सहयोग और भाईचारे की भावना को बढ़ावा दिया गया है जो किसी भी समाज की मजबूती का आधार होती है। उनका साहित्य समाज में विभिन्न धर्मों, जातियों और समुदायों के बीच सामंजस्य और सह-अस्तित्व की शिक्षा देता है। उनका मानना है कि समाज तभी विकसित हो सकता है जब उसमें सभी लोग मिलजुल कर एकता और प्रेमपूर्वक रहें। पं० जगन्नाथ के लोक साहित्य में नैतिकता और कर्त्तव्यपालन की भावना का स्थान सर्वोपरि है। उनकी रचनाओं में आदर्श व्यवहार, सत्यता, ईमानदारी और कर्त्तव्यपालन जैसे सामाजिक मूल्यों की चर्चा की गई है जो व्यक्ति को सही और गलत का बोध कराते हैं और समाज में एक अच्छे नागरिक के गुण विकसित करते हैं।
An Actualization Way of Mathematical Internal Connection in Mathematics Curriculum: Focused on Horizontal Connection of Mathematical Concepts
Authors:   The Korea Society Of Educational Studies In Mathematics, Lee Ye-Jin , Chang Hyewon
Published: November 2024

This study analyzes the New York State curriculum to identify reflection patterns of horizontal connections of mathematical concepts. We divided horizontal connection into connection within domain(WD) and connection between domains(BD) and analyzed the number and patterns of reflections by grade and type. Based on the results, we derived implications for realizing connections in our curriculum in terms of constitutive method and relational content aspects.
Development of nurses’ competencies in caring for patients at high risk of dysphagia
Authors: Kasimovskaya N.A. , Sorokina A.G. , Peters T.V. , Bandurina E.N.
Published: November 2024

Dysphagia is the most common cause of aspiration pneumonia in elderly and senile patients with neurodegenerative diseases, after surgical interventions and prolonged artificial lung ventilation. The article presents a study of the capabilities of nurses of surgical and neurological departments in caring for patients at risk of dysphagia. The developed Nutrition Assessment Map of a patient at risk of dysphagia with the results of approbation in the surgical and neurological department during patient care is presented. The confidence intervals of the occurrence of dysphagia symptoms in patients and the results of the coincidence of the diagnosis of dysphagia symptoms by nurses according to the Nutrition Assessment Card and the confirmation of dysphagia by doctors are presented. The use of it by nurses in the process of care can help to detect dysphagia in a timely manner and reduce the risk of secondary complications in patients with a high risk of swallowing disorders.
Degenerative disc disease in nurse practice
Authors: Skvortsov V.V. , Gorbach A.N. , Akramov I.N.
Published: November 2024

Osteochondrosis of the spine plays a leading role among diseases of the peripheral nervous system, being a serious social problem in many countries. The significant prevalence of this disease among people of working age, high rates of disability, large economic losses determine the relevance of this problem, its epidemiological and socio-economic significance. Osteochondrosis of the spine can be considered as a polyethological, but monopathogenetic disease, the clinical signs of which depend on various endogenous and exogenous factors. This article provides basic information about the treatment of neurological syndromes of osteochondrosis of the spine. The issues of pathogenesis of vertebrogenic diseases of the nervous system are considered. The biomechanical features of the spine under normal conditions and in the event of pathology are briefly described. The main methods of the therapeutic approach in the case of this pathology, the use of chondroprotectors as a necessary supplement to the therapy of NSAIDs are considered.
Experience of implementing professional cleaning technologies in a modern medical organization
Authors: Fedko N.A. , Malkina L.V. , Shilo D.A.
Published: November 2024

The traditional model of organizing cleaning and disinfection of premises, the use of technically outdated cleaning equipment, currently used in many medical organizations, do not meet modern requirements for epidemiological safety and economic efficiency. The introduction technologies of professional cleaning help to reduce the labor intensity of cleaning, reduces the risk of errors associated with the dilution of disinfectants, and prevents premature wear of treated surfaces and floor coverings. The optimization of the functional duties of the personnel of the internal insourcing service, which carries out professional cleaning based on a systematic approach to training employees, selecting high-quality technologies and effective methods of cleaning, compliance requirements for ensuring the sanitary and hygienic regime, improving the quality control of clean contributes to improving the quality of disinfecting measures in the framework of non-specific prevention of infections associated with the provision of medical care. The introduction of insourcing helps to increase the efficiency of using the economic resources of a modern medical organization.
Specifics of nursing staff training in the workplace in the hospital
Authors: Zakharova G.I. , Ostrovskaya I.V. , Sokolova E.A. , Sukhotina N.V. , Bogacheva M.V.
Published: November 2024

During the study of the peculiarities of on-the-job training of nursing staff in hospital settings, the opinion of 417 employees of State Clinical Hospital №52 DZM about the work of the training room was studied. Respondents highly appreciate the need for on-the-job training. At the same time, there are reasons that prevent nursing staff from on-the-job training.
Woolly-flowered astragalus (Astragalus dasyanthus Pell.) is the most promising source of non-toxic organic selenium
Authors: Poluboyarinov P.A. , Moiseeva I.Y. , Fedorov A.V. , Strukov V.I. , Sergeeva-Kondrachenko M.Y. , Vinogradova O.P. , Denisova A.G. , Vikhrev D.V. , Panina E.S. , Petrova E.V. , Burmistrova S.S.
Published: November 2024

The biological role of selenium in the human body and the possible consequences of an overdose of the microelement are considered. An assessment is given of the most common forms of the mineral in the composition of pharmaceutical preparations in terms of the effectiveness of eliminating selenium deficiency and safety. Particular attention is paid to the organic form of selenium — selenocysteine. The advantages of using selenium hyperaccumulating plants in the treatment of selenium deficiency conditions are discussed. The information about Astragalus dasyanthus Pell. as a plant-concentrator of selenium is presented. A method of biofortification with L-selenocystin is described, which makes it possible to increase the concentration of selenium in the aerial part of astragalus up to 70 mсg per 100 mg of its dry weight. The characteristics of Russian selenium-containing preparations based on astragalus woolly-flowered, grown using the method of biofortification with L-selenocystin, are given.
Overcoming professional burnout in medical staff in dentistry
Authors: Brudyan G.S. , Rusina N.A.
Published: November 2024

Professional burnout is a significant problem in the health professions, especially in dentistry. This article focuses on practical recommendations for preventing and overcoming burnout. It includes data and examples of professional burnout, analyzes the main causes and consequences, and offers individual and organizational strategies for overcoming this phenomenon.
Application of Appropriate Technology for Automatic Hatching Machines in the Kelompok Ternak Bebek Mukti in Rajamandala Village
Authors: Sumaryana Yusuf , Kusmayadi Andri , Sundari Ristina Siti , Heryadi D Yadi , Nurcahya Intan
Published: November 2024

Automatic incubator is an incubator device designed to hatch eggs artificially with automatically controlled temperature, humidity, and egg turning settings, in the hope of increasing the success rate of hatching, saving time and energy, and enabling hatching on a larger scale. The purpose of this community service is to apply appropriate technology for automatic egg hatching to improve the knowledge, skills, accessibility, and income of farmers in Rajamandala Village. This program is a Kosabangsa scheme through a collaboration between Universitas Perjuangan Tasikmalaya and Universitas Siliwangi. This activity starts in September 2024 to December 2024 in Rajamandala Village, Rajapolah District, Tasikmalaya Regency. Kosabangsa activities consist of various activities, namely socialization / counseling regarding automatic incubators, training on their application which can be controlled using Android, and assistance in the application of automatic incubator technology to partners until their marketing activities. The target partner for this activity is Kelompok Ternak Bebek Mukti with a total of 20 group members as participants in the activity. The results of this community service activity show that the application of automatic incubator technology in Kelompok Ternak Bebek Mukti is able to increase the percentage of hatching power and reduce the hatching time compared to the application of manual incubator technology that is commonly used. The output of this activity is able to increase the knowledge, skills, accessibility, and income of Kelompok Ternak Bebek Mukti partners in the egg hatching process
ENVELHECIMENTO E QUALIDADE DE VIDA EM GRUPO DE IDOSOS EM PONTA DA FRUTA
Authors: Sousa Adriane Ramos , Stöckl Maristela , Bravo Paula Morellato , SantAna Igor Gonçalves , Barbosa Daniel Boldi , Gonçalves Ericka Teran , Braga Bruna Sathler Faria , Martins Nathalia Roveta Ferreira , Morte Emanuella Boa , Almeida Lainerlani Simoura de
Published: November 2024

De acordo com a Organização Pan-Americana de Saúde (2003), o envelhecimento é definido como “um processo sequencial, individual, acumulativo, irreversível, universal, não patológico, de deterioração d
Incluir brincando
Authors: Miranda Octávia Cristina Scherrer Nogueira de , Araújo Márcia Moreira de
Published: November 2024

A publicação foi criada com o objetivo de apoiar professores no desenvolvimento de práticas pedagógicas inovadoras, que possam despertar nos alunos o gosto pela matemática. Baseado nas orientações de confecção de materiais educativos de Kaplún (2003), surge como um recurso onde os docentes encontrarão estratégias e atividades que não só facilitam a compreensão dos conceitos matemáticos, mas também tornam o aprendizado mais significativo, atrativo e inclusivo, atendendo às necessidades de todos os estudantes, inclusive aqueles com Transtorno do Déficit de Atenção com Hiperatividade (TDAH).