bluuebunny/crossref_metadata_2025 huggingface dataset:
Zasady prawa w świetle materiałów legislacyjnych
Authors: Bielska-Brodziak Agnieszka , Tkacz Sławomir
Published: October 2018

The paper discusses the possibilities for using legislative materials in the process of establishing a catalogue of legal principles and determining their content. The starting point for the analysis was the conviction that the catalogue of legal principles and their content are established through discourse. One element of this discourse is the legislator’s voice in the form of „traces” left in various places. The interpreter may refer to both the legislator’s expressions in texts of normative acts and to expressions presented in legislative materials. Until recently, given their insufficient availability, legislative materials were seldom used in the discourse on legal principles. Through an analysis of legislative materials developed for the 2016 amendment of the Code of Criminal Proceedings, the authors show that these materials can be a source of valuable information on the legislative intent. The paper concludes with the following observation: the currently available access opportunities offered by information technologies mean that expanding the context that shapes the catalogue and content of the various principles through the use of legislative materials appears necessary.
Trybunalskie i sądowe stosowanie zasady „ignorantia iuris nocet” na gruncie praktyki orzeczniczej w Polsce
Authors: Woś Tomasz
Published: October 2018

The article discusses the issue of the Constitutional Court’s and other courts’ application of the principle of ignorantia iuris nocet in the practice of issuing rulings. Based on the analysis of the case law, it presents the Constitutional Court’s standpoint concerning the role of the principle of ignorantia iuris nocet in the Polish system of law and its application in the Constitutional Court’s case law. At the same time, it discusses other courts’ application of this principle, i.e. its influence on the decision-making processes of the application of law by the Supreme Court, courts of appeal and administrative courts. The analysis of the case law show that the principle of ignorantia iuris nocet plays a special role in the Polish system of law. In their decisions, both the Constitutional Court and other courts concerned emphasise that the Polish system of law, like other contemporary systems of law, is based on this principle, and its violence would lead to unpredictable results in the practice of issuing rulings. There are no major differences between the application of the principle of ignorantia iuris nocet by the Constitutional Court and other courts concerned. In cases involving the ignorance of the law, both the Constitutional Court and other courts commonly recognise and apply, within the scope of their competence, the principle of ignorantia iuris nocet. Administrative law takes a particular stance on the application of this principle. In the Supreme Administrative Court’s judicature, a jurisdictional approach has been adopted that recognises that the operation of this principle is reduced in administrative procedure. In turn, the study of the case law of provincial administrative courts shows that these courts still have not adopted a uniform jurisdictional pattern in this respect.
Microfluidic paper-based analytical devices (µPADs) for fast and ultrasensitive sensing of biomarkers and monitoring of diseases
Authors: Abdollahi-Aghdam Abdollah , Majidi Mir Reza , Omidi Yadollah
Published: October 2018

Through the development of analytical techniques, microscaled devices have displayed attractive advantages, including ultrasensitive detection and analysis, cost-effectiveness, portability, process integrity, multi-process functionality, and in-situ analysis. In the last decade, a new generation of analytical devices has emerged based on the cellulose materials – so-called microfluidic paper-based analytical devices (µPADs) – a field that will change the face of the diagnosis of different diseases and sensing of a wide range of biological/chemical/biochemical phenomena. The main aim of the current editorial is to highlight the importance of the µPADs in the research and development of diagnostic devices and pharmaceuticals.
Mechanism Analysis and Experimental Study of Emulsified Wax Curing Agent as an Isolation Layer for Concrete Pavement
Authors: Yuan Jianbo , Yao Jialiang , Wang Huicong , Lin Yi
Published: October 2018

The functional mechanism of emulsified wax curing agent (EWCA) as an isolation layer of cement concrete pavement (CCP) was analyzed. Reducing the friction between layers and improving the hydrophobic function of concrete surface can weaken the combination of surface course and base course, as well as the formation of weak transition layer, which is generated during the construction of concrete undersurface course. After the cement concrete surface was sprayed with EWCA, its contact range was measured to be 97.3°∼101.1° in the contact angle test. With the nuclear magnetic resonance equipment, the study on the microstructure of the pavement slab of EWCA’s isolation layer was carried out. The isolation layer of EWCA can reduce the porosity of transition layer and enhance its compatibility. The effect of EWCA on the interlayer performance of concrete pavement was explored by the interlayer bonding and friction coefficient tests with different amounts of EWCA and different texture depths of base course. The Coulomb model of interlayer bonding and frictional resistance was established, which preliminarily indicated the functional mechanism of CCP’s emulsified isolation layer.
Unilateral, 3D Arm Movement Kinematics Are Encoded in Ipsilateral Human Cortex
Authors: Bundy David T. , Szrama Nicholas , Pahwa Mrinal , Leuthardt Eric C.
Published: October 2018

There is increasing evidence that the hemisphere ipsilateral to a moving limb plays a role in planning and executing movements. However, the exact relationship between cortical activity and ipsilateral limb movements is uncertain. We sought to determine whether 3D arm movement kinematics (speed, velocity, and position) could be decoded from cortical signals recorded from the hemisphere ipsilateral to the moving limb. By having invasively monitored patients perform unilateral reaches with each arm, we also compared the encoding of contralateral and ipsilateral limb kinematics from a single cortical hemisphere. In four motor-intact human patients (three male, one female) implanted with electrocorticography electrodes for localization of their epileptic foci, we decoded 3D movement kinematics of both arms with accuracies above chance. Surprisingly, the spatial and spectral encoding of contralateral and ipsilateral limb kinematics was similar, enabling cross-prediction of kinematics between arms. These results clarify our understanding that the ipsilateral hemisphere robustly contributes to motor execution and supports that the information of complex movements is more bihemispherically represented in humans than has been previously understood.

SIGNIFICANCE STATEMENTAlthough limb movements are traditionally understood to be driven by the cortical hemisphere contralateral to a moving limb, movement-related neural activity has also been found in the ipsilateral hemisphere. This study provides the first demonstration that 3D arm movement kinematics can be decoded from human electrocorticographic signals ipsilateral to the moving limb. Surprisingly, the spatial and spectral encoding of contralateral and ipsilateral limb kinematics was similar. The finding that specific kinematics are encoded in the ipsilateral hemisphere demonstrates that the ipsilateral hemisphere contributes to the execution of unilateral limb movements, improving our understanding of motor control. Additionally, the bihemisheric representation of voluntary movements has implications for the development of neuroprosthetic systems for reaching and for neurorehabilitation strategies following cortical injuries.
Tropomodulin Isoform-Specific Regulation of Dendrite Development and Synapse Formation
Authors: Omotade Omotola F. , Rui Yanfang , Lei Wenliang , Yu Kuai , Hartzell H. Criss , Fowler Velia M. , Zheng James Q.
Published: October 2018

Neurons of the CNS elaborate highly branched dendritic arbors that host numerous dendritic spines, which serve as the postsynaptic platform for most excitatory synapses. The actin cytoskeleton plays an important role in dendrite development and spine formation, but the underlying mechanisms remain incompletely understood. Tropomodulins (Tmods) are a family of actin-binding proteins that cap the slow-growing (pointed) end of actin filaments, thereby regulating the stability, length, and architecture of complex actin networks in diverse cell types. Three members of the Tmod family, Tmod1, Tmod2, and Tmod3 are expressed in the vertebrate CNS, but their function in neuronal development is largely unknown. In this study, we present evidence that Tmod1 and Tmod2 exhibit distinct roles in regulating spine development and dendritic arborization, respectively. Using rat hippocampal tissues from both sexes, we find that Tmod1 and Tmod2 are expressed with distinct developmental profiles: Tmod2 is expressed early during hippocampal development, whereas Tmod1 expression coincides with synaptogenesis. We then show that knockdown of Tmod2, but not Tmod1, severely impairs dendritic branching. Both Tmod1 and Tmod2 are localized to a distinct subspine region where they regulate local F-actin stability. However, the knockdown of Tmod1, but not Tmod2, disrupts spine morphogenesis and impairs synapse formation. Collectively, these findings demonstrate that regulation of the actin cytoskeleton by different members of the Tmod family plays an important role in distinct aspects of dendrite and spine development.

SIGNIFICANCE STATEMENTThe Tropomodulin family of molecules is best known for controlling the length and stability of actin myofilaments in skeletal muscles. While several Tropomodulin members are expressed in the brain, fundamental knowledge about their role in neuronal function is limited. In this study, we show the unique expression profile and subcellular distribution of Tmod1 and Tmod2 in hippocampal neurons. While both Tmod1 and Tmod2 regulate F-actin stability, we find that they exhibit isoform-specific roles in dendrite development and synapse formation: Tmod2 regulates dendritic arborization, whereas Tmod1 is required for spine development and synapse formation. These findings provide novel insight into the actin regulatory mechanisms underlying neuronal development, thereby shedding light on potential pathways disrupted in a number of neurological disorders.
The Determinants of Infant Mortality in Neonatal Period
Authors: Sari Indah Purnama
Published: October 2018

Neonatal mortality is mortality happening to newborn baby who are alive during the birth but died after first month of life (28 days after being delivered). This study used data from 2013 reports. The aim of this study was to identify determinants of neonatal mortality risk. Case control design was used. Population of cases were newborn baabybies who dying within 28 days after the birth, while the population of controls were newborn baby who do not die within 28 days, selected from the same population of cases. Cases and controls proportion were 1:3 with 39 babies served as cases and 117 babies as controls. Cases were identified form The Health Office and PHC reports, meanwhile controls were selected from neighbor of cases. Univariate, bivariate and multivariate analysis were conducted in this study. The results shows that newborn weight (p=0,03), immediately breastfeeding (p=0,00) and postnatal care (p=0,00) are the risk factors for neonatal mortality.
Effect of Aquarobic and Weight Training on Cortisol Levels in Obese Women
Authors: Mukarromah Siti Baitul , Susanto Hardhono , Rahayu Tandiyo
Published: October 2018

Exercise is physical stress which potentially causes disruption of homeostasis, especially in sports that is excessively done. Weight Training (LB) and Aquarobic Exercise (LA) can be modulators of handling stress. This research aims at investigating the effect of the difference between LB and LA to physical stress in obese women. The study was conducted in 2014. The method used in this study was randomized experimental pretest-posttest control group design in 36 obese women, aged 45-50 years who were divided into 3 groups, group LB 50% RM, 3 sets, 12 repetition, treatment two times a day for 8 weeks (n = 12), LA 75% HRmax, treatment 2 days for 8 weeks (n = 12) and control group (n = 12). Body Mass Index (BMI) and cortisol levels were measured before and after the treatment. Hypothesis testing was conducted using test (One-Way ANOVA and Kruskal-Wallis) and the mean difference test (Tukey HSD and Mann Whitneys). The results of BMI is increased in the WT group and is decreased in LA group as compared to control group (p <0.05). The decrease of cortisol level is higher than in LA and LB group and controls (p <0.05). LB and LA affect the physical stress that is characterized by the increase in cortisol levels in obese women. Conclusion: LB is more dominant than LA in increasing physical stress.
The Effectiveness of Passion Fruit Juice Consumption as Pain Reliever for Bruise Trauma in Pencak Silat Athletes
Authors: Irawan Roy Januardi
Published: October 2018

Pencak Silat is a martial art that has a risk of causing micro-trauma due to physical impact. This trauma will stimulate the secretion of prostaglandin, a compound in the body which is a mediator of pain and inflammatory response that promote pain in bruised trauma. Passion fruit contains high level of anti-inflammatory and antioxidant substances. The objective of this study was to understand the effectiveness of passion fruit juice consumption in reducing bruised trauma pain in Pencak Silat athletes of PSHT Belotan Magetan. The research design is a quantitative descriptive with quasi-experimental. The pretest and posttest group of 20 people PSHT Belotan Magetan Pencak Silat athletes with an average age of 13.4 0.94 years were divided into treatment group (K1) and control group (K0) with 10 subjects respectively. Each treatment group (K1) subject was given the juice twice a day for 10 consecutive days. We used paired sample T-test to assess the mean variance of the group. The result showed that there was a decrease of pain intensity in both the treatment group and the control group. The pain intensity difference assessed by a Bourbonnais Rating Scale in the treatment group showed a significant difference with the t value of 7,216 and a probability value of 0,000, while the control group showed t value of 3,000 and probability value of 0,015. There was a decrease in the athletes muscle soreness who were given passion fruit juice twice a day for 10 days. The athletes pain intensity was in middle category.
Utilization of Health Operational Assistance (BOK) in Nutrition Services in Public Health Center
Authors: Pay Dece Mery Natalia , Sinaga Mindo , Pelokilla Marthen R
Published: October 2018

Since BOK was launched in 2010, BOK utilization rate continued to increase while the NTT provincial nutrition service coverage did not increase, until 2013. This research aimed to analyze the relationship between the availability of operational funds, the availability of human resources, officers knowledge, infrastructure support, heads support and the appropriateness of fund utilization using BOK in nutritional services. This was a quantitative research which supported by a qualitative, cross-sectional design in 2015. The total sample of 250 health workers in 26 health centers of North Central Timor regency was included in this study. Data analysis was done using descriptive, bivariate and multivariate analyses. The results of the bivariate analysis using chi square test showed an association of (p <0.05) the availability of human resources (p = 0.017), officers knowledge (p = 0.000), infrastructure support (p = 0.004), heads support (p = 0.000) and the appropriateness of BOK fund utilization (p = 0.000) with the use of BOK in nutritional services. Meanwhile, the availability of operational funds is not associated with the use of BOK in nutritional services. Multivariate analysis showed that health centers with adequate human resources availability are seven times more likely to take advantage and make a good use of the nutritional services using BOK compared to health centers with the lack of human resources, after the infrastructure and head variable controlled. The government is required to provide adequate human resources, including financial administrative personnel and operational funding for health centers to optimize nutritional services. The government also needs to monitor the use of funds regularly and tiered to improve service coverage at the health center.
Effectiveness of Environmentally Friendly Mosquito Trap Contained Sugar Yeast Solution
Authors: Rosanti Tutik Ida , Mardihusodo S Juwono , Artama Wayan T
Published: October 2018

Environmentally friendly mosquitoes trap using common daily materials used by community may give hopes in reducing mosquitoes density. This study aims to determine the effectiveness of environmentally friendly mosquitoes trap made from bottle contained sugar yeast solution for reducing the number of trapped mosquitoes. This study consist of two phases and quasi experimental design was used. Mann Whitney test was used to determine the differences the number of trapped mosquitoes indoor and outdoor. The result showed p value 0,000 which was lower than ? value (0,05), so there was significant difference between the number of indoor and outdoor trapped mosquitoes. The average Rank score of outdoor mosquitoes trap (42,75) was more than indoor mosquitoes trap (18,25). We concluded that the mosquitoes trapped which contained of sugar-yeast solution was effective for trapping the mosquitoes especially outdoor .
Analogue Rice as The Vehicle of Public Nutrition Diversity
Authors: Noviasari Santi , Widara Suba Santika , Budijanto Slamet
Published: October 2018

Analogue rice is artificial rice product made from non-rice raw material by extrusion technique, which can be the vehicle of public nutrition diversity. The objectives of this research were to formulate and characterize analogue rice made from of sorghum, mocaf and other additional material. The method of analogue rice production is by twin screw extruder hot extrusion done in 2013. The research steps were the formulation of analogue rice, sensory evaluation to choose the best formula, and physico-chemical characterization of the best formula. The best two samples that were chosen are analogue rice made from 30% sorghum flour, 15% cornstarch, and 15% arenga starch (analogue rice B) and analogue rice made from 30% mocaf and 30% cornstarch (analogue rice F). Analogue rice B has 21.72% of amylose (medium) with 4% of dietary fiber while analogue rice F has low amylose which is 14.49%, make it more sticky, with 4.21% of dietary fiber.
Acceptance Behavior of Electronic Prescription System
Authors: Sidiq Rapitos
Published: October 2018

Electronic prescription is one of information systems to support medical services based on computer technology to support clinical decision (Clinical Decision Support, CDS). Studies proved that the use of this system can decrease medication error. One of the hospitals that have applied this system is Meuraxa Hospital. This study aimed to determine the acceptance behavior of electronic prescription information systems. The respondents of this study were 30 doctors at specialist clinic. Data was collected by distributing questionnaires on August 1st-23rd, 2016. Data was processed using SmartPLS 3.0. Results showed that there was a positive effect of effort expectancy factor on behavioral intention and facilitating factors on the use behavior towards receipt of electronic prescription. It is expected that the management of Meuraxa hospital develop an existing electronic prescription system by accommodating the needs of the system users.
The Impact of Environmental Changes Caused by Earthquake Toward Emotional Problems of Preschool Children
Authors: Triana Vivi
Published: October 2018

Natural disasters can result in death and disability that lead to loss, grief and emotional disturbance reactions. The disorder is more common in children underwent development period. Neurological changes in children who experience Post Traumatic Syndrome Disorder (PTSD) 1.5 times greater than in adults. This study aims to determine the impact of environmental changes caused by the earthquake in Padang Pariaman district towards emotional problems of children aged 3-5 years. We used retrospective cohort study design in a population of children aged 3-5 years in September 2009. The sample was 219 people who were taken using stratified random sampling method. Data was collected by interviewing the parents through a questionnaire and analyzed using univariate and bivariate analysis. We observed a significant relationship between environment damage (p= 0.017), occupation (p= 0.02) and economic status (p= 0.03) with emotional problems in children. Education did not have a significant relationship with emotional problems in children.
Midwife’s Knowledge and Attitude in Kangaroo Mother Care To Premature Neonatal in the Public Health Centre in Batang
Authors: Samsuri Muhammad Taadi , Kholifah Kholifah , Sukini Tuti , Astuti Tulus Puji
Published: October 2018

One of indicators in the successful health affair in a country is the number of infant mortality rate. Causes of mortality among others are respiratory disorders 37%, prematurity 34%, sepsis12%, hypothermia7%, post mature 3% and congenital defect 1% and blood defect or icterus 6%. Infant mortality due to hypothermia can be prevented by practical method as an alternative to incubator namely Kangaroo Care Method. The implementation of Kangaroo Care Method must be monitored and evaluated by health care provider especially the midwife. This research was conducted in 2015.The purpose of this research was to find out the correlation between midwives’ knowledge and their attitude in implementing Kangaroo Method to premature infant.This research was observasional with design cross sectional approach. The number of population was 65 midwives and as a sample 49 midwives. The data were collected by means of questionnaire. Data analyses used bivariate Spearman rho test. The result of the research showed that 32 midwives (65.3%) had good knowledge and most of 27 midwives (55.1%) had positive attitude. It was obtained from Spearman rho test ρ value 0.001 and correlative coefficient (r) 0.696. The conclusion, there was any close correlation between knowledge and attitude of midwives in kangaroo care method.
Dust Exposures, IgE Levels, History of Allergy, and Symptoms of Allergy in Poultry Workers
Authors: Wijayanti Yuni , Sutomo Adi Heru , Astuti Indwiani , Asmara Widya
Published: October 2018

Poultry dust exposure may increase workers’ health risks, particularly in the form of respiratory allergic reactions. This study aimed to identify mold content of the dust and to analyze the association between dust exposure, IgE level, history of allergy, and symptoms of allergy. This study used cross sectional design with total samples of 33 workers. The data were analyzed using chi-square test and multivariate logistic regression. This study found 93.33% growth of Aspergillus sp., 69.7% work duration > 3 years, 84.8% high IgE levels, 18.2% history of allergy, and 69.7% symptoms of allergy. Dust exposure and history of allergy did not show significant correlation with symptoms of allergy while IgE levels had significant correlation with p-value of 0.036. Workers with high IgE-level were 15.986 times more likely to have symptoms of allergy (p-value 0.028). Aspergillus sp. as dust allergen potentially increased IgE levels and might become the base for facilitation of early and independent preventive and promotive efforts of workers’ health.
Correlation between Acute Stroke and Concentration of Creatine Kinase Myocardial Band, Troponin T, Hemoglobin, and Electroyltes
Authors: Fahrina Destika , Sinurat Puji Pinta , Rambe Aldy Sjarifuddin
Published: October 2018

Currently, there were only a few studies regarding the correlation between concentration of creatine kinase-myocardial band (CKMB), troponin T, hemoglobin, and electrolytes and acute stroke. This study aimed to understand the difference of mean concentration of CKMB, troponin T, hemoglobin, and electrolytes and their relationship with acute stroke. This was a cross sectional study using samples of 30 subjects who were selected with consecutive non random sampling. The subjects were acquired from acute stroke patients who were proven clinically and using computed tomography (CT) scan at Haji Adam Malik General Hospital. Demographic data were analyzed using descriptive statistic. The result showed that there were no difference in demographical characteristics between the subjects. In conclusion, there were no differences in mean of CKMB, troponin T, hemoglobin, and electrolytes in acute stroke. No correlation was found between acute stroke and concentration of CKMB, troponin T, hemoglobin, and electrolytes.
Improvement of Nutritional Quality of Tuber Flour as Local Food Resource
Authors: Soesilowati Etty , Martuti Nana Kariada Tri , Paramita Octavianti
Published: October 2018

Tuber plants are sources of carbohydrates which could be used as strategic national food reserves. Beside high carbohydrates, tubers also contain a number of bioactive compounds which have physiological effects as antioxidants. This research aimed to develop tuber flour products and increase additional value through the use of appropriate technology and diversification of processed products. Research samples were 16 tuber species. The method was crystallisation by utilization of blower system to accelerate the process of water content reduction. The data were analyzed using proximat analysis. Water content was 5.61-15%, ash content was 0.4-5.31%, carbohydrate content was 82-88%, protein content was 0.67-6.32%, and fat content was 1-7%. The result showed that chemical content of Suweg flour with pragelatinization method at 70ºC for 60 minutes had the highest water, ash, and fiber content which were 5.79%, 2.49%, and 43.73%, respectively. Meanwhile, the highest carbohydrate content obtained by heating for 10 minutes was 25.80%. Tubers flour is worthy to be used as raw materials for food industry.
Position and Chance of Indonesia Family Planing to Achieve RPJMN 2015-2019 and FP2020 Targets
Authors: Pinandari Anggriyani Wahyu , Wilopo Siswanto Agus
Published: October 2018

Indonesia’s commitment at London Summit 2012 was to reduce TFR by increasing contraceptive users by 2020. This paper aimed to estimate the number, trend and possibility to achieve RPJMN and FP2020 targets in Indonesia. This was a descriptive study using secondary data from Indonesia national survey. Data are presented in line, bar, and pie graphs, also table to explain trend and possibility of Indonesia FP to achieve 2020 targets. Using 2012 data as the baseline, RPJMN and FP2020 targets will be achieved if CPR grows 0.5 point/year. However, recent growth was insufficient, only 0.3 additional points. The current CPR is behind the target and 1 point/year growth rate is needed to approximate the target trajectory. Based on three surveys in 2015 (PMA, SUSENAS and SUPAS), Indonesia’s CPR was predicted to be 61.1% on 2020. This is five points lower than the 2020 target, 66.3%. This discrepancy shows that Indonesia would not achieve FP target on RPJMN 2015-2019. Based on recent survey in 2015, CPR trajectory is predicted to be 5 points below the target. 1.5 points annual growth is needed to achieve the 2020 goals.
Circulating vitamin D level and mortality in prostate cancer patients: a dose–response meta-analysis
Authors: Song Zhen-yu , Yao Qiuming , Zhuo Zhiyuan , Ma Zhe , Chen Gang
Published: October 2018

Previous studies investigating the association of circulating 25-hydroxyvitamin D level with prognosis of prostate cancer yielded controversial results. We conducted a dose–response meta-analysis to elucidate the relationship. PubMed and EMBASE were searched for eligible studies up to July 15, 2018. We performed a dose–response meta-analysis using random-effect model to calculate the summary hazard ratio (HR) and 95% CI of mortality in patients with prostate cancer. Seven eligible cohort studies with 7808 participants were included. The results indicated that higher vitamin D level could reduce the risk of death among prostate cancer patients. The summary HR of prostate cancer-specific mortality correlated with an increment of every 20 nmol/L in circulating vitamin D level was 0.91, with 95% CI 0.87–0.97, P = 0.002. The HR for all-cause mortality with the increase of 20 nmol/L vitamin D was 0.91 (95% CI: 0.84–0.98, P = 0.01). Sensitivity analysis suggested the pooled HRs were stable and not obviously changed by any single study. No evidence of publications bias was observed. This meta-analysis suggested that higher 25-hydroxyvitamin D level was associated with a reduction of mortality in prostate cancer patients and vitamin D is an important protective factor in the progression and prognosis of prostate cancer.
A new p.(Ile66Serfs*93) IGF2 variant is associated with pre- and postnatal growth retardation
Authors: Rockstroh Denise , Pfäffle Heike , Le Duc Diana , Rößler Franziska , Schlensog-Schuster Franziska , Heiker John T , Kratzsch Jürgen , Kiess Wieland , Lemke Johannes R , Abou Jamra Rami , Pfäffle Roland
Published: October 2018

Objective

The IGF/IGF1R axis is involved in the regulation of human growth. Both IGF1 and IGF2 can bind to the IGF1R in order to promote growth via the downstream PI3K/AKT pathway. Pathogenic mutations in IGF1 and IGF1R determine intrauterine growth restriction and affect postnatal body growth. However, to date, there are only few reports of pathogenic IGF2 mutations causing severe prenatal, as well as postnatal growth retardation.

Results

Here we describe a de novo c.195delC IGF2 variant (NM_000612, p.(Ile66Serfs*93)) in a 4-year-old patient with severe pre- and post-natal growth retardation in combination with dystrophy, facial dimorphism, finger deformities, as well as a patent ductus. Cloning and sequencing of a long-range PCR product harboring the deletion and a SNP informative site chr11:2153634 (rs680, NC_000011.9:g.2153634T>C) demonstrated that the variant resided on the paternal allele. This finding is consistent with the known maternal imprinting of IGF2. 3D protein structure prediction and overexpression studies demonstrated that the p.(Ile66Serfs*93) IGF2 gene variation resulted in an altered protein structure that impaired ligand/receptor binding and thus prevents IGF1R activation.

Conclusion

The severity of the phenotype in combination with the dominant mode of transmission provides further evidence for the involvement of IGF2 in growth disorders.
French Endocrine Society Guidance on endocrine side effects of immunotherapy
Authors: Castinetti F , Albarel F , Archambeaud F , Bertherat J , Bouillet B , Buffier P , Briet C , Cariou B , Caron Ph , Chabre O , Chanson Ph , Cortet C , Do Cao C , Drui D , Haissaguerre M , Hescot S , Illouz F , Kuhn E , Lahlou N , Merlen E , Raverot V , Smati S , Verges B , Borson-Chazot F
Published: October 2018

The management of cancer patients has changed due to the considerably more frequent use of immune checkpoint inhibitors (ICPIs). However, the use of ICPI has a risk of side effects, particularly endocrine toxicity. Since the indications for ICPI are constantly expanding due to their efficacy, it is important that endocrinologists and oncologists know how to look for this type of toxicity and how to treat it when it arises. In view of this, the French Endocrine Society initiated the formulation of a consensus document on ICPI-related endocrine toxicity. In this paper, we will introduce data on the general pathophysiology of endocrine toxicity, and we will then outline expert opinion focusing primarily on methods for screening, management and monitoring for endocrine side effects in patients treated by ICPI. We will then look in turn at endocrinopathies that are induced by ICPI including dysthyroidism, hypophysitis, primary adrenal insufficiency and fulminant diabetes. In each chapter, expert opinion will be given on the diagnosis, management and monitoring for each complication. These expert opinions will also discuss the methodology for categorizing these side effects in oncology using ‘common terminology criteria for adverse events’ (CTCAE) and the difficulties in applying this to endocrine side effects in the case of these anti-cancer therapies. This is shown in particular by certain recommendations that are used for other side effects (high-dose corticosteroids, contraindicated in ICPI for example) and that cannot be considered as appropriate in the management of endocrine toxicity, as it usually does not require ICPI withdrawal or high-dose glucocorticoid intake.
Arte esquemático pintado en el noroeste peninsular: una visión integrada transfronteriza
Authors: Bacelar Alves Lara , Comendador Rey Beatriz
Published: October 2018

El noroeste de la Península Ibérica es una región particularmente interesante para el estudio del arte rupestre europeo porque aquí se encuentra el área de transición entre dos importantes tradiciones: el Arte Atlántico, que está típicamente grabado sobre afloramientos al aire libre y el Arte Esquemático pintado, principalmente en abrigos rocosos y cavidades poco profundas. El primero se extiende a lo largo de la fachada atlántica de Galicia occidental y noroeste de Portugal, mientras que este último se extiende desde el sur y centro de Iberia hasta el noreste de Portugal y las provincias españolas de León y Asturias, a lo largo de la cuenca de los ríos Duero, Sil, Navia y Nalón. Hasta el año 2017, resultaba sorprendente la ausencia de pinturas rupestres en el área oriental de Galicia, a pesar de constituir una extensión de esas regiones naturales.El objetivo de este trabajo es proporcionar el primer enfoque integrado de los sitios con pinturas de Arte Esquemático en el noroeste, estableciendo los antecedentes, en cuanto al análisis espacial, sobre el concepto de regiones biogeográficas con el fin de superar los sesgos de estudios anteriores, tradicionalmente confinados a límites administrativos. Ello ofrece una visión general de las diferentes tradiciones del arte prehistórico y sus contextos, evalúa los hallazgos recientes en su contexto más amplio, y investiga los paisajes de las pinturas rupestres, con el fin de establecer estrategias potenciales para futuros estudios de campo en la Galicia oriental.
Genotype-by-Environment-by-Environment Interactions in the Saccharomyces cerevisiae Transcriptomic Response to Alcohols and Anaerobiosis
Authors: Sardi Maria , Krause Molly , Heilberger Justin , Gasch Audrey P
Published: October 2018

Next generation biofuels including longer-chain alcohols such as butanol are attractive as renewable, high-energy fuels. A barrier to microbial production of butanols is the increased toxicity compared to ethanol; however, the cellular targets and microbial defense mechanisms remain poorly understood, especially under anaerobic conditions used frequently in industry. Here we took a comparative approach to understand the response of Saccharomyces cerevisiae to 1-butanol, isobutanol, or ethanol, across three genetic backgrounds of varying tolerance in aerobic and anaerobic conditions. We find that strains have different growth properties and alcohol tolerances with and without oxygen availability, as well as unique and common responses to each of the three alcohols. Our results provide evidence for strain-by-alcohol-by-oxygen interactions that moderate how cells respond to alcohol stress.
PRP4KA, a Putative Spliceosomal Protein Kinase, Is Important for Alternative Splicing and Development in Arabidopsis thaliana
Authors: Kanno Tatsuo , Venhuizen Peter , Wen Tuan-Nan , Lin Wen-Dar , Chiou Phebe , Kalyna Maria , Matzke Antonius J M , Matzke Marjori
Published: October 2018

Prp4 kinase (Prp4k) is the first spliceosome-associated kinase shown to regulate splicing in fungi and metazoans, but nothing is yet known about its functions in plants. Here, Kanno and Venhuizen et al. report...

Splicing of precursor messenger RNAs (pre-mRNAs) is an essential step in the expression of most eukaryotic genes. Both constitutive splicing and alternative splicing, which produces multiple messenger RNA (mRNA) isoforms from a single primary transcript, are modulated by reversible protein phosphorylation. Although the plant splicing machinery is known to be a target for phosphorylation, the protein kinases involved remain to be fully defined. We report here the identification of pre-mRNA processing 4 (PRP4) KINASE A (PRP4KA) in a forward genetic screen based on an alternatively spliced GFP reporter gene in Arabidopsis thaliana (Arabidopsis). Prp4 kinase is the first spliceosome-associated kinase shown to regulate splicing in fungi and mammals but it has not yet been studied in plants. In the same screen we identified mutants defective in SAC3A, a putative mRNA export factor that is highly coexpressed with PRP4KA in Arabidopsis. Whereas the sac3a mutants appear normal, the prp4ka mutants display a pleiotropic phenotype featuring atypical rosettes, late flowering, tall final stature, reduced branching, and lowered seed set. Analysis of RNA-sequencing data from prp4ka and sac3a mutants identified widespread and partially overlapping perturbations in alternative splicing in the two mutants. Quantitative phosphoproteomic profiling of a prp4ka mutant detected phosphorylation changes in several serine/arginine-rich proteins, which regulate constitutive and alternative splicing, and other splicing-related factors. Tests of PRP4KB, the paralog of PRP4KA, indicated that the two genes are not functionally redundant. The results demonstrate the importance of PRP4KA for alternative splicing and plant phenotype, and suggest that PRP4KA may influence alternative splicing patterns by phosphorylating a subset of splicing regulators.
Blogųjų naujienų diskursas Lietuvos sovietmečio spaudoje
Authors: Gedzevičienė Dalia
Published: October 2018

[abstract in English; full article and abstract in Lithuanian]

The rhetoric and the stylistics – the choice of text style, genre, and rhetorical devices – of Soviet bad news discourse is analysed in this paper. This discourse is represented by 193 reports regarding disasters, crimes, and violation of socialistic moral which were published in the daily paper Komjaunimo tiesa (eng. The Truth of the Komsomol) in 1970–1973. It was found that the bad news in the selection of official texts of this period distinguishes by a much lower register of Newspeak – unlike as in the articles of first pages, there is almost no pathos here, the militaristic metaphors are used in the text of the article only, but they cannot be seen in the headings. One of the main rhetorical devices is an irony, which is created by using phraseology, jargon, famous quotes, dialogues, etc., – everything, which looks like a daily colloquial language. The choice of text form which is more related to fiction than to journalism (essay, satire) may be treated as one of the pretexts which justify in the eyes of the readers an idea of an author to write in a different language than it was ordinary in the context of ideologized press language of that period. By using the corresponding rhetoric, they believed to accomplish the propagandistic aim of these texts more efficiently – to suggest an image of more safe, democratic, successful, and self-critical country than it really was.
The Translation of D. H. Lawrence’s Metaphors: the French Censored Passages in “The Rainbow” as a Case in Point
Authors: Louzir Aïcha
Published: October 2018

[full article and abstract in English]

The aim of this study is to explore D. H. Lawrence’s style through the prism of his use of metaphor. As a particularly enlightening method, I shall compare some of the censored passages in “The Rainbow” (1915) against their French translations (1939, 2002). Focusing my attention on their stylistic particularities, I will examine the manner in which they were translated into French. The central argument of my paper is that Lawrence’s metaphors related to the body are a relevant tool highlighting the author’s vision of human relationships, within the context of prevalent views in the beginning of the 20th century. The British authorities banned “The Rainbow” since its first publication and accused Lawrence of pornography. Therefore, it is important to glance back in order to understand the reason behind the censorship and see that the translations of Lawrence’s oeuvre were decisive in spreading his ideas beyond the frontiers of his country of origin. My analysis mainly draws on a descriptive approach but it is at the crossroads of several paradigms, namely the interpretative approach in Translation Studies and the cognitive approach to the study of metaphors.
Kiekybinė parodomųjų įvardžių vartosena verstiniame ir neverstiniame tekste
Authors: Bartkutė Darija
Published: October 2018

[full article and abstract in Lithuanian; abstract in English]

The article aims to estimate the distribution of demonstrative pronouns in the translated and nontranslated Lithuanian text as compared to the English original. The quantitative method and contrastive analysis based on the triangulation of data sources are used to reveal whether demonstrative pronouns show different distribution patterns in the English original and Lithuanian translation compared to the translated and non-translated Lithuanian text. The research material was collected from Harry Potter and the Goblet of Fire by J. K. Rowling and a fantasy novel Hour of the Wolf by A. Tapinas. The preferences identified did not indicate significant differences in the tendencies for the use of demonstrative pronouns in the translated and non-translated text of Lithuanian fiction but revealed significant cross-linguistic contrasts in the quantitative use of demonstratives. It was therefore presumed that there was no communicative difference between the translated and non-translated Lithuanian fictional text due to the genre and language conventions for the use of deictics and that the Lithuanian text demonstrated a preference for a more pronounced pragmatic explicitness than the English language text.
Identifying Risk and Management of Acute Haemodynamic Decompensation During Catheter Ablation of Ventricular Tachycardia
Authors: Muser Daniele , Castro Simon A , Liang Jackson J , Santangeli Pasquale ,   Cardiac Electrophysiology, Cardiovascular Division, Hospital of the University of Pennsylvania, USA,   Cardiac Electrophysiology, Cardiovascular Division, Hospital of the University of Pennsylvania, USA,   Cardiac Electrophysiology, Cardiovascular Division, Hospital of the University of Pennsylvania, USA,   Cardiac Electrophysiology, Cardiovascular Division, Hospital of the University of Pennsylvania, USA
Published: October 2018

Radiofrequency catheter ablation (CA) has an established role in the management of patients with structural heart disease presenting with recurrent ventricular tachycardia (VT). Due to the complex underlying substrate, high burden of comorbidities and concomitant heart failure (HF) status, these patients may be at higher risk of periprocedural complications. The prolonged low-output state related to VT induction and mapping, as well as the fluid overload due to irrigated CA and the use of general anaesthesia, may decompensate the HF status, leading to multiple-organ failure and increase in early post-procedural mortality. Proper identification of patients at high risk of periprocedural acute haemodynamic decompensation (AHD) has important implications in terms of procedural planning (i.e. prophylactic use of mechanical assistance devices) and pre-procedural management in order to optimise the HF status. In the present manuscript we focus on the clinical predictors of AHD and the strategies to improve pre-procedural risk stratification, as well as the evidence supporting the use of haemodynamic support during CA procedures.
On a length problem for close-to-convex functions
Authors: Nunokawa Mamoru , Sokół Janusz
Published: October 2018

Let L(f, r) denote the length of the closed curve which is the image of |z| = r < 1 under the mapping w = f(z). We establish some sufficient conditions for L(f, r) to be bounded and for f(z) to in the classes of strongly close-to-convex function of order α and to be strongly Bazilevič function of type β of order α. Moreover, we prove an inequality connected with the Fejér-Riesz's inequality.
KARAKTERISTIK POPULASI DAN TINGKAT PEMANFAATAN KEPITING BAKAU (Scylla serrata Forskal 1775) DI PERAIRAN ASAHAN DAN SEKITARNYA, SUMATERA UTARA
Authors: Putri Pane Andina Ramadhani , Suman Ali
Published: October 2018

Peningkatan jumlah ekspor kepiting (Scylla serrata Forskal, 1775) di wilayah perairan Asahan memacu peningkatan penangkapan yang dapat berpengaruh terhadap populasi dan kelestarian. Penelitian ini bertujuan untuk mengetahui karakteristik populasi dan tingkat pemanfaatan kepiting bakau di perairan Asahan dan sekitarnya. Pengambilan sampel dilakukan setiap bulan dari Januari sampai dengan Nopember 2016 di tempat pendaratan kepiting oleh enumerator. Data dianalisa dengan metode Electronic LEngth Frequency Analisys-I (ELEFAN-I) dari FAO-ICLARM Stock Assessment Tools II (FiSAT II). Hasil penelitian menunjukkan pola pertumbuhan kepiting bakau bersifat allometrik negatif pada kisaran lebar karapas antara 85 - 175 mm dan bobot tubuh 127 – 1.152,5 gram. Rata-rata ukuran lebar karapas tertangkap dengan jaring dan bubu adalah 118,6 mm dan ukuran matang gonad pertama kali adalah 120,6 mm. Laju pertumbuhan (K) 1,38 per tahun dan lebar karapas maksimum (CW) sebesar 201 mm. Laju kematian total (Z) sebesar 3,59 per tahun, laju kematian karena penangkapan (F) dan laju kematian alami (M) masing-masing 2,27 per tahun dan 1,32 per tahun. Laju pemanfaatan (E) kepiting bakau di perairan Asahan adalah 0,63 per tahun atau sudah melebihi nilai optimum penangkapan. Agar sumber daya kepiting terjamin kelestariannya, maka harus dilakukan pengurangan upaya penangkapan sekitar 26 %.Increase in the volume of giant mud crab exports (Scylla serrata Forskal, 1775) in the Asahan waters stimulate the increasing catches that affect population and sustainability. This study aims to determine the population characteristics and the exploitation level of giant mud crab in Asahan and adjacent waters. Monthly sampling was done from January to November 2016 at crab landing sites by enumerator. The data were analyzed using Electronic Length Frequency Analysys-I (ELEFAN-I) method available in FAO-ICLARM Stock Assessment Tools II (FiSAT II) program. The results showed that the growth pattern of giant mud crab was negative allometric with carapace width between 85 - 175 mm and individual body weight 127 - 1,152.5 grams. The average carapace’s width caught by net and trap was 118.6 mm and the size of gonad first maturity was 120.6 mm. Growth rate (K) 1.38 per year and maximum carapace width (CW) of 201 mm. Total mortality rate (Z) of 3.59 per year, mortality rate due to fishing (F) and natural mortality rate (M) was 2.27 per year and 1.32 per year respectively. The rate of exploitation (E) of mangrove crab in Asahan waters was 0.63 or has exceeded the optimum value. For the sustainability of crab resource a reduction of 26% in fishing effort is suggested.