bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of organic and inorganic fertilizers on growth, yield and nutrient use efficiency of clonal tea (Camellia sinensis)
Authors: MOKAYA BITANGE N. , CHEMINING’WA GEORGE N. , AMBUKO JANE L. , NYANKANGA RICHARD O.
Published: January 2023

Abstract. Mokaya BN, Chemining’wa GN, Ambuko JL, Nyankanga RO. 2018. Effect of organic and inorganic fertilizers on growth yield and nutrient use efficiency of clonal tea (Camellia sinensis). Cell Biol Dev 2: 15-26. This research observed how to boost tea yields in small-scale tea producers using inorganic NPK fertilizers yearly while the cost of fertilizers has been rising, resulting in a decrease in net returns. The influence of different rates of organic and inorganic fertilizers on the soil chemical characteristics, growth, yield, and nutrient usage efficiency of clonal tea was investigated in an experiment. In the 2014/2015 production year, experiments were put up in Kianjokoma, Embu County. Organic Rutuba® and inorganic NPK fertilizers were employed (26.5.5). No-fertilizer control, 625 kg NPK/ha, 937.5 kg NPK/ha, 1875 kg NPK/ha, 625 kg Rutuba/ha + 625 kg NPK/ha, 625 kg Rutuba/ha, 937.5 kg Rutuba/ha, and 1875 kg Rutuba/ha were the treatments. These treatments were repeated three times in a randomized full-block design. Green leaf yield, black made tea yield, leaf length, and leaf breadth were among the crop statistics obtained. The soil data collected at the trial included the pH, exchangeable acidity, organic carbon, micronutrients, and macronutrients. Plant utilization efficiency for nitrogen, phosphate, and potassium were also measured. The cost and net revenue of each fertilizer treatment were calculated as well. The data were subjected to analysis of variance, and the least significant difference test was used to separate the groups at p 0.05. Adding organic Rutuba to the soil raised the pH and the amounts of Mn, Cu, Fe, Zn, Ca, and Mg. Compared to the no-fertilizer control and farmers' practice, the application of 625 kg Rutuba/ha + 625 kg NPK/ha resulted in enhanced leaf length, breadth, fresh green leaf yield, and made tea yield. According to the findings, the application of Rutuba fertilizer considerably improved agronomic efficiency, apparent nutrient recovery, and partial factor productivity of N, P, and K compared to inorganic NPK fertilizer. The study also found that applying NPK 26.5.5 at rates more than 625 kg/ha did not affect growth, yield, nutrient usage efficiency, or net returns. However, because organic Rutuba has a low macronutrient level, the study indicated that it should not be used alone in tea manufacturing. More research is needed to discover the best NPK and Rutuba fertilizer mix, as well as the influence of organic Rutuba fertilizer on tea quality.
Cluster analysis of Dioscorea alata accessions of Purwodadi Botanic Gardens (Indonesia) collection based on morphological characteristic and SSR markers
Authors: MAS’UDAH SHOFIYATUL , FAUZIAH FAUZIAH , HAPSARI LIA
Published: January 2023

Abstract. Mas’udah S, Fauziah, Hapsari L. 2019. Cluster analysis of Dioscorea alata accessions of Purwodadi Botanic Gardens (Indonesia) collection based on morphological characteristics and SSR markers. Cell Biol Dev 3: 6-12. The morphological characteristics of D. alata accessions show a high diversity, especially the tubers with varying form, size, weight, color, and flesh. Classification and naming of D. alata accessions generally use different local names in each region, causing problems. This study aimed to classify 20 accession numbers of D. alata collection of Purwodadi Botanic Garden collected from East Java based on tuber morphological characteristics and simple sequence repeat (SSR) molecular markers. Based on the morphological characteristic, the accessions showed high variation. However, from the seventeen characters observed, two characters were similar, and 15 others were diverse. The main morphological characteristics that contribute to the cluster are tuber skin color, tuber shape, and the color of the inner skin of the tuber. Clustering results based on DNA amplification showed different groups compared to the morphological characters cluster, although some accessions with close morphological characters were in the same molecular Group. The accession origin could not be used as the group marker. Marker E11 and A7 have the highest polymorphisms in this experiment. As conservation strategies, accessions with high-level similarity could be represented by one accession for maintenance efficiency. Conserving species until varieties level with different characters could enrich germplasm for breeding development.
High-resolution wavefront sensing and aberration analysis of multi-spectral extreme ultraviolet beams
Authors: Du Mengqi , Liu Xiaomeng , Pelekanidis Antonios , Zhang Fengling , Loetgering Lars , Konold Patrick , Porter Christina L. , Smorenburg Peter , Eikema Kjeld S. E. , Witte Stefan
Published: January 2023

Coherent multi-spectral extreme ultraviolet beams have great potential
for providing high spatial and temporal resolution for microscopy and
spectroscopy applications. But due to the limitations of
short-wavelength optics and the broad bandwidth, it remains a
challenge to perform quantitative, high-resolution beam
characterization. Here we present a wavefront sensing solution based
on multiplexed ptychography, with which we show spectrally resolved,
high-resolution beam reconstructions. Furthermore, using these
high-fidelity quantitative wavefront measurements, we investigate
aberration transfer mechanisms in the high-harmonic-generation
process, where we present and explain harmonic-order-dependent
astigmatism inheritance from the fundamental wavefront. This
ptychographic wavefront sensing concept thus enables detailed studies
of the high-harmonic-generation process, such as spatiotemporal
effects in attosecond pulse formation.
Usual source of care and access to care in the US: 2005 vs. 2015
Authors: Lee De-Chih , Shi Leiyu , Wang Jing , Sun Gang
Published: January 2023

Introduction

The study examined the association of usual source of care (USC) and healthcare access using a series of access indicators including both positive and negative measures for the US population in 2005 and 2015 while controlling for individual sociodemographic and socioeconomic characteristics. Results of the study would help advance the knowledge of the relationship between USC and access to care and assist decisionmakers in targeted interventions to enhance USC as a strategy to enhance access.

Methods

The household component of the US Medical Expenditure Panel Survey (MEPS-HC) in 2005 and 2015 were used for the study. To estimate the relative risk of having USC on access to care, odds ratios (ORs) and their 95% confidence intervals (CIs) were used with unconditional logistic regression and adjusted for socioeconomic and demographic characteristics.

Results

Those with USC were significantly more likely to have better access to care compared to those without USC. The USC-access connection remains significant and strong even after controlling for socioeconomic and demographic characteristics. Regarding subpopulations likely to lack USC, two notable findings are that racial/ethnic minorities (Black, Asian, and Hispanic) are more likely than White to lack USC and that those uninsured are more likely to lack USC.

Conclusion

The study contributes to the literature on USC and access to care and has significant policy and practical implications. For example, having a USC is critical to accessing the health system and is particularly important as a tool to addressing racial disparities in access.
Coping strategy among the women with metastatic breast cancer attending a palliative care unit of a tertiary care hospital of Bangladesh
Authors: Islam Nashid , Bhuiyan A. K. M. Motiur Rahman , Alam Afroja , Chowdhury Mostofa Kamal , Biswas Jheelam , Banik Palash Chandra , Molla Md. Maruf Ahmed , Kowshik Mostofa Monwar , Sarker Mridul , Ahmed Nezamuddin
Published: January 2023

Background

Breast cancer is one of the leading cancers among the Bangladeshi women. Coping helps these patients to adjust with this life-changing disease. Each individual has unique and different coping mechanism. But we know a little regarding their coping strategies. This study aims to explore the different coping strategies adopted by the women with metastatic (stage IV) breast cancer attending the palliative care unit and their relationship with the common mental health issues like anxiety and depression.

Methods

This cross-sectional study was conducted among 95 patients with metastatic (stage IV) breast cancer attending the Department of Palliative Medicine, Bangabandhu Sheikh Mujib Medical University, Bangladesh from April 2021 to September 2021. Data was collected by face-to-face interview using a structured questionnaire adapted from Hospital Depression and Anxiety Scale (HADS), Brief COPE inventory and Eastern Cooperative Oncology Group (ECOG) performance scale. Pearson correlation test was used to find the relationships between various domains of coping strategies and psychological variables. Correlation matrix was done to observe the internal correlation among different coping strategies. Kruskal-Wallis H test was done to find the relationship between different coping strategies and ECOG performance status.

Result

The mean age of the respondents was 48.9 ± 9.9 years. Most of them were married (94.7%), Muslim (92.6%) and homemakers (82.1%). Commonly used coping strategies by the patients were: acceptance (median 10; IQR 10), religion (median 9; IQR 8–10) and instrumental support (median 9; IQR 6–10). Significantly strong positive correlation was found between emotional and instrumental support (R = 0.7; p = 0.01), planning, acceptance and active coping (R = 0.7; p = 0.01); behavioral disengagement, self distraction and denial (R = 0.5; p = 0.01). Significantly fair negative correlation was observed between active coping and depression (R = -0.4, p <0.001). Patients with better performance status on ECOG scale (Grade 0–2) leaned more on the positive coping strategies like instrumental support, emotional support, positive reframing and venting.

Conclusion

Different coping strategies, especially positive coping helps the patients to adapt with their disease over time. All women suffering from breast cancer should be routinely screened and assessed for psychological distress and ensure early intervention and management to promote a better quality of life.
Multilocus genotyping of Giardia duodenalis in pre-weaned calves with diarrhea in the Republic of Korea
Authors: Park Yu-Jin , Cho Hyung-Chul , Jang Dong-Hun , Park Jinho , Choi Kyoung-Seong
Published: January 2023

Giardia duodenalis is a protozoan parasite that infects humans, companion animals, livestock, and wildlife. Infections in cattle caused by this parasite are often asymptomatic, but such infections can cause diarrhea, reduced weight gain, and ill-thrift in young calves. Although G. duodenalis causes diarrhea in calves, only a few studies have been conducted on calves in the Republic of Korea (ROK). Here, we aimed to determine the prevalence and distribution of G. duodenalis assemblages in pre-weaned calves with diarrhea in the ROK, identify the association between the occurrence of G. duodenalis and the age of calf, and perform molecular characterization of G. duodenalis. We collected 455 fecal samples from pre-weaned native Korean calves (≤60 days old) with diarrhea in four different regions. G. duodenalis was detected using nested PCR targeting the beta-giardin (bg) gene, and positive samples were further genotyped for the glutamate dehydrogenase (gdh) and triosephosphate isomerase (tpi) genes. The overall prevalence of G. duodenalis in calves with diarrhea was 4.4% (20/455) based on the analysis of bg. The highest prevalence was observed in calves aged 11−30 days (7.5%; 95% confidence interval: 3.7%–11.3%), whereas the lowest prevalence was observed in neonatal calves. From the 20 samples that were positive for bg, 16, 5, and 6 sequences were obtained following genotyping of bg, gdh, and tpi, respectively. Sequencing analysis of the bg gene revealed the presence of assemblage E (n = 15) and sub-assemblage AⅠ (n = 1) in the samples. Moreover, we detected mixed infections with assemblages E and A in two calves for the first time. Among the sequences obtained herein, two new subtypes of assemblage E were detected in gdh and tpi sequences each. The results suggest that G. duodenalis is an infectious agent causing diarrhea in calves, and pre-weaned calves are at a higher risk of infection than neonatal calves. Multilocus genotyping should be performed to confirm the presence of potentially zoonotic genotypes. These results highlight the importance of cattle as a source of zoonotic transmission of G. duodenalis to humans.
Investigating the evolution of undergraduate medical students’ perception and performance in relation to an innovative curriculum-based research module: A convergent mixed methods study launching the 8A-Model
Authors: Otaki Farah , AlHashmi Deena , Khamis Amar Hassan , Azar Aida Joseph
Published: January 2023

Background

Embedding into undergraduate medical programs experiential research curricula, based on holistic theories of education which emphasize participation in the social world, remains uncommon. The purpose of this study was to investigate the journey of undergraduate medical students in relation to an innovative compulsory curriculum-based research module, which has a prominent experiential learning component.

Methods

A convergent mixed methods study design was adapted to develop a systemic understanding of the experience of the undergraduate medical students throughout the respective research module. As such, the students’ perception of the experience was qualitatively explored using thematic analysis (n = 15). In parallel, the students’ performance data were quantitatively analyzed using multi-repeated ANOVA (n = 158). The findings from both types of analyses (i.e., qualitative and quantitative study components) were then mapped onto each using joint display analysis.

Findings

The exploration generated four themes that correspond to sequential steps that the students go through to effectively integrate the scientific research method. These themes include: 1- Attend-Acquire, 2- Accumulate-Assimilate, 3- Apply-Appreciate, and 4-Articulate-Affect. Quantitatively, two distinct clusters of mean Grade Point Average were revealed (p<0.01). Joint display analysis enabled integrating the qualitative and quantitative findings, generating the 8A-Model.

Conclusion

The evidence-driven 8A-Model, generated by this study, highlights that medical students’ understanding of the true value of research seems to increase as they progress in the module. They begin expressing appreciation of the significance of the experience when they start implementing what they are learning as part of their own research studies. It is recommended for such a research module, with a firm experiential learning component, to be integral to undergraduate medical programs. This is expected to improve the future physicians’ research competences, and in turn add value in terms of quality of care and patient outcomes.
Efectos metalingüisticos y metacontextuales
Authors: Mena Ricardo
Published: January 2023

Algunas aseveraciones que no son acerca del significado de las palabras usadas pueden transmitir información acerca de ese significado. En (Mena, 2022) ofrecí una teoría para explicar este fenómeno de manera puramente semántica. Lo novedoso de la teoría consiste en incluir las interpretaciones del lenguaje en las circunstancias de evaluación: los parámetros respecto a los cuales evaluamos los contenidos de las expresiones ling¨üísticas. En este ensayo argumento que las aseveraciones de oraciones que contienen indéxicos pueden transmitir información acerca del contexto de uso, aunque esas oraciones no sean acerca de contextos. Dado esto, ofrezco una extensión de mi teoría de los efectos metalingüísticos para modelar a los indéxicos de manera similar. También discuto las muchas maneras en que la teoría aquí presentada se distingue de otras semánticas bidimensionales.
The machine-like repair of aging. Disentangling the key assumptions of the SENS agenda
Authors: García-Barranquero Pablo , Bertolaso Marta
Published: January 2023

The possibility of curing aging is currently generating hopes and concerns among entrepreneurs, experts, and the general public. This article aims to clarify some of the key assumptions of the Strategies for Engineered Negligible Senescence agenda, one of the most prominent paradigms for rejuvenation. To do this, we present the three fundamental claims of this research program: (1) aging can be repaired; (2) rejuvenation is possible through the reversal of all molecular damage; (3) and the human organism is a sophisticated machine. Secondly, we argue that this agenda fits with a machine conception of the organism (described by Daniel Nicholson); we show that, if aging is understood from this philosophical approach, there is an internal confusion in the research program between what is repair and what is rejuvenation. Finally, we state that this theoretical viewpoint connects with scientific criticism and reinforces the idea that there are limits to the aspirations to live indefinitely young.
Conceptual recombination and stimulus-independence in non-human animals
Authors: Danón Laura
Published: January 2023

Camp (2009) distinguishes two varieties of conceptual recombination. One of them is full-blown or (as I prefer to call it) spontaneous recombination. The other is causal-counterfactual recombination. She suggests that while human animals recombine their concepts in a full-blown way, many non-human animals are capable of conceptual recombinability but only of the causal-counterfactual kind. In this paper, I argue that there is conceptual space to draw further sub-distinctions on how different animals may recombine their concepts. More specifically, I propose to differentiate between a) narrow causal-counterfactual recombination; b) broad causal-counterfactual recombination; c) lean spontaneous recombination; d) robust spontaneous recombination. Afterwards, I focus on how these distinctions relate to several previous philosophical ideas on the representational capacities of non-human animals. I also provide several empirical examples suggesting that some animals display one or another of these four ways of recombining concepts, at least in some contexts.
Das culturas da alimentação ao culto dos alimentos, Volume II
Authors: Dias Paula Barata , Asfora Wanessa , Soares Carmen , Grieco Allen
Published: January 2023

A presente obra reúne estudos de especialistas de diferentes áreas do conhecimento que se dedicaram a refletir sobre fenómenos alimentares a partir de dois eixos de análise distintos porém intercomunicantes: as culturas alimentares e o culto dos alimentos. Esses eixos organizam a obra do ponto de vista formal e conceptual, pois revelam o paradoxo expresso pelas culturas alimentares enquanto forças vivas, mas invisíveis participadoras da construção da cultura (volume I), e, ao mesmo tempo, pelo destaque de alguns alimentos enquanto objetos de formas diversas de culto, que emergem da invisibilidade para se destacarem enquanto signos dos discursos e das práticas culturais humanas – religiosa, ética, artística, gastronómica e medicinal (volume II). A riqueza de temáticas que atravessam tempos e espaços variados e de abordagens multi- e transdisciplinares fazem da obra mais um contributo importante para a área dos Estudos da Alimentação e das Humanidades, em geral.
Terminology and Provision for Students with Learning Difficulties: An Examination of Australian State Government Education Department Websites
Authors:   University of Southern Queensland, Todd Nicole , Gaunt Lorraine ,   Charles Sturt University, Porta Tom ,   University of Southern Queensland
Published: January 2023

Students with learning difficulties form the largest group of students with additional needs in Australian mainstream classrooms. However the terminology surrounding these students differs broadly across the country. A consistent and shared understanding of the term learning difficulties is vital, as this impacts the identification and equitable provision of support for students experiencing difficulties with learning. The website of each Australian state/territory government education department was examined to determine to how students with learning difficulties are formally identified and supported. It was found that considerable differences, and even conflicting information, exist both within and across education systems. Implications and the significance of this situation are discussed.
RADIAL EXTRUSION OF A PIPE BILLET WITH INTERNAL LEDGE. EXPERIMENTAL VERIFICATION OF THEORETICAL FORMULAS DURING EXTRUSION WITH HARDENING OF ALUMINUM ALLOY AB
Authors: Vorontsov A. L. , Reshikov E. O.
Published: January 2023

A continuation of the experimental verification of theoretical results, begun in previous articles, is outlined. Various studies of extrusion of a hardening material – aluminum alloy AB – have been carried out. The method of accounting for hardening in technological calculations is shown in detail. The high accuracy of the obtained calculation formulas is confirmed.
MODERN METHODS OF FINISHING AND HARDENING PROCESSING OF CYCLOIDAL HELICAL SURFACES
Authors: Nesterkina N. P. , Kuznetsov E. A. , Zhuravleva Yu. A. , Mikaeva S. A.
Published: January 2023

The paper analyzes the results of comparative studies of the lighting characteristics of LED filament lamps of the A60 type form factor from various manufacturers: luminous flux, power consumption, luminous efficiency, pulsation coefficient during the lamp burning time up to 6000 hours.Gorenje The test results show that the stability of the luminous flux after 6000 h of gorenje all LED filament lamps ranged from 91.3 to 96.4 %, which corresponds to the luminous flux stability code 9 according to GOST IEC 62612–2019, except for the Feron LB-57 7W 2700K lamp – 89.3 % (luminous flux stability code 8).
Stimulation of extrinsic sympathetic nerves differentially affects neurogenic motor activity in guinea pig distal colon
Authors: Smolilo David J. , Hibberd Timothy J. , Costa Marcello , Dinning Phil G. , Keightley Lauren J. , De Fontgalland Dayan , Wattchow David A. , Spencer Nick J.
Published: January 2023

The speed of pellet propulsion through the isolated guinea pig distal colon in vitro significantly exceeds in vivo measurements, suggesting a role for inhibitory mechanisms from sources outside the gut. The aim of this study was to investigate the effects of sympathetic nerve stimulation on three different neurogenic motor behaviors of the distal colon: transient neural events (TNEs), colonic motor complexes (CMCs), and pellet propulsion. To do this, segments of guinea pig distal colon with intact connections to the inferior mesenteric ganglion (IMG) were set up in organ baths allowing for simultaneous extracellular suction electrode recordings from smooth muscle, video recordings for diameter mapping, and intraluminal manometry. Electrical stimulation (1–20 Hz) of colonic nerves surrounding the inferior mesenteric artery caused a statistically significant, frequency‐dependent inhibition of TNEs, as well as single pellet propulsion, from frequencies of 5 Hz and greater. Significant inhibition of CMCs required stimulation frequencies of 10 Hz and greater. Phentolamine (3.6 μM) abolished effects of colonic nerve stimulation, consistent with a sympathetic noradrenergic mechanism. Sympathetic inhibition was constrained to regions with intact extrinsic nerve pathways, allowing normal motor behaviors to continue without modulation in adjacent extrinsically denervated regions of the same colonic segments. The results demonstrate differential sensitivities to sympathetic input among distinct neurogenic motor behaviors of the colon. Together with findings indicating CMCs activate colo‐colonic sympathetic reflexes through the IMG, these results raise the possibility that CMCs may paradoxically facilitate suppression of pellet movement in vivo, through peripheral sympathetic reflex circuits.
Family expectations towards Spanish language maintenance and heritage language programs in Germany
Authors: Álvarez Mella Héctor , Blattner Charlotte , Gómez-Pavón Durán Ana
Published: January 2023

Family and educational institutions are the main centers of socialization in heritage language. Beyond the communicative and learning dynamics that take place in both environments, linguistic socialization also depends to a large extent on the relationship of families with educational spaces. The aim of this paper is to discuss families’ expectations regarding the intergenerational transmission of Spanish and to explore their attitudes towards heritage language and educational programs in Germany. For this purpose, the results of an exploratory study based on surveys will be presented to compare the main arguments justifying Spanish-speaking families’ decision to include heritage language courses or bilingual education spaces in their family language management in the German context. The analysis of the perception of families and their attitudes shows that the positive valuation of the family and instrumental dimension of heritage language influence families to include bilingual programs or heritage language classes in their family language management.
Ink Talks: Processing Compassion Fatigue through Culturally Relevant Arts-Making
Authors: Wang Ying Ingrid
Published: January 2023

This paper explores the power of the arts and the spiritual support of one’s own culture in helping an immigrant arts therapist process professional compassion fatigue. Through autoethnographic narrative and arts-based inquiry, I intend to dive into the emotional distress arising from this immigrant therapist’s experience of compassion fatigue in a creative way. In this cultural and arts-based research journey, I immerse in my personal/professional experience through the arts-making process as an immigrant arts therapist to explore expression, transformation, and enlightenment as ways of processing compassion fatigue. Through this insightful personal journey, I argue that the importance of self-disclosure and self-exploration through culturally relevant creativity might enhance the wellbeing of the immigrant therapist. In addition, this study attempts to discuss the topic of therapists’ compassion fatigue through a decolonizing lens and with Eastern philosophical perspectives.
Stereoisomer‐specific reprogramming of a bacterial flagellin sialyltransferase
Authors: Kint Nicolas , Dubois Thomas , Viollier Patrick H
Published: January 2023

Glycosylation of surface structures diversifies cells chemically and physically. Nucleotide‐activated sialic acids commonly serve as glycosyl donors, particularly pseudaminic acid (Pse) and its stereoisomer legionaminic acid (Leg), which decorate eubacterial and archaeal surface layers or protein appendages. FlmG, a recently identified protein sialyltransferase, O‐glycosylates flagellins, the subunits of the flagellar filament. We show that flagellin glycosylation and motility in Caulobacter crescentus and Brevundimonas subvibrioides is conferred by functionally insulated Pse and Leg biosynthesis pathways, respectively, and by specialized FlmG orthologs. We established a genetic glyco‐profiling platform for the classification of Pse or Leg biosynthesis pathways, discovered a signature determinant of eubacterial and archaeal Leg biosynthesis, and validated it by reconstitution experiments in a heterologous host. Finally, by rewiring FlmG glycosylation using chimeras, we defined two modular determinants that govern flagellin glycosyltransferase specificity: a glycosyltransferase domain that either donates Leg or Pse and a specialized flagellin‐binding domain that identifies the acceptor.
Interferon regulates neural stem cell function at all ages by orchestrating mTOR and cell cycle
Authors: Carvajal Ibañez Damian , Skabkin Maxim , Hooli Jooa , Cerrizuela Santiago , Göpferich Manuel , Jolly Adrien , Volk Katrin , Zumwinkel Marc , Bertolini Matilde , Figlia Gianluca , Höfer Thomas , Kramer Guenter , Anders Simon , Teleman Aurelio A , Marciniak‐Czochra Anna , Martin‐Villalba Ana
Published: January 2023

Stem cells show intrinsic interferon signalling, which protects them from viral infections at all ages. In the ageing brain, interferon signalling also reduces the ability of stem cells to activate. Whether these functions are linked and at what time interferons start taking on a role in stem cell functioning is unknown. Additionally, the molecular link between interferons and activation in neural stem cells and how this relates to progenitor production is not well understood. Here we combine single‐cell transcriptomics, RiboSeq and mathematical models of interferon to show that this pathway is important for proper stem cell function at all ages in mice. Interferon orchestrates cell cycle and mTOR activity to post‐transcriptionally repress Sox2 and induces quiescence. The interferon response then decreases in the subsequent maturation states. Mathematical simulations indicate that this regulation is beneficial for the young and harmful for the old brain. Our study establishes molecular mechanisms of interferon in stem cells and interferons as genuine regulators of stem cell homeostasis and a potential therapeutic target to repair the ageing brain.
Análise das ameaças antropogênicas com base em laudos periciais criminais em espaços territoriais especialmente protegidos pela legislação ambiental no noroeste do estado de São Paulo
Authors: Costa Alexandre Augusto
Published: January 2023

A partir de 2003, houve um avanço das áreas de exploração de cana-de-açúcar no estado de São Paulo em razão da demanda gerada pela entrada dos veículos bicombustíveis (flex fuel) no mercado consumidor brasileiro. Com base nisso, realizou-se o levantamento dos laudos periciais criminais produzidos entre os anos 2003 e 2009 na região noroeste do estado de São Paulo, objetivando analisar os impactos antrópicos em espaços territoriais especialmente protegidos pela legislação ambiental. A quantidade total de áreas degradadas foi variável ao longo dos anos e não houve correlação significativa entre o número de degradações e o tamanho das áreas degradadas. No total, foram registradas 325 áreas afetadas ao longo do período, das quais 86,9% inseridas em Áreas de Preservação Permanente, 12,2% em fragmentos florestais e 0,9% em Reservas Legais. A superfície total degradada atingiu 815,3 ha, sendo 72,4% em Áreas de Preservação Permanente, 21,9% em fragmentos florestais e 5,8% em Reservas Legais. Foram identificadas seis categorias de ameaças antrópicas: pecuária, agricultura, fogo, represamento, expansão urbana e depósito de inservíveis. A agricultura representou o uso mais extenso da terra, principalmente a canicultura. As áreas de influência com raio de 2 km ao redor dos locais degradados por pecuária, por agricultura e por depósito de material inservível apresentaram diferenças significativas na densidade de vegetação de entorno, bem como nas malhas hidrográfica e rodoviária. O predomínio de Áreas de Preservação Permanente em estágio pioneiro de regeneração sugere que os processos de sucessão ecológica são continuamente interrompidos.
Considerações teórico-experimentais sobre o resfriamento pós morte
Authors: Marinho George Santos , De Farias Robson Fernandes
Published: January 2023

Realizou-se um estudo comparativo entre dados de temperatura relativos ao resfriamento de corpos. Foram considerados dados obtidos a partir de dois modelos matemáticos e dados experimentais, obtidos a partir do resfriamento de uma amostra de carne bovina. Sensores pirométricos foram inseridos na amostra para registro da temperatura durante o resfriamento em ambiente com controle térmico. As comparações foram realizadas por meio de gráficos de intervalos de tempo de resfriamento. Diferenças significativas foram constatadas entre os dois modelos teóricos utilizados no estudo quando esses modelos eram comparados aos resultados experimentais. Apresentam-se considerações sobre as possíveis causas das diferenças observadas. Perspectivas sobre o desenvolvimento da Tanatologia são descritas.
Aspectos periciais, individuais e sociais de ocorrências policiais de mulheres vítimas de agressão física doméstica atendidas no posto avançado de Polícia Técnica de Vera Cruz - BA
Authors: Souza Oliveira Luana Thainá , Araújo Vitor Ramos , De Mello Andrade Adriana Conceição
Published: January 2023

A agressão física contra a mulher ainda é comum na sociedade contemporânea. É preciso, portanto, ter um panorama geral dessas vítimas para que seja possível realizar intervenções significativas contra tal ameaça à saúde pública. Este estudo objetiva avaliar, através de laudos periciais, os aspectos periciais, individuais e sociais de ocorrências policiais de mulheres vítimas de agressão física doméstica no Posto Avançado de Polícia Técnica de Vera Cruz - Ba, no período de julho de 2017 a janeiro de 2020. Trata-se de um estudo descritivo, com população de 93 laudos periciais de mulheres atendidas no período de julho de 2017 a janeiro de 2020. As variáveis foram divididas em perfis individuais e sociais, e aspectos referentes à ocorrência policial das vítimas. O perfil mais prevalente foi de mulheres entre 18 e 35 anos, pardas, evangélicas, solteiras, com ensino fundamental incompleto, trabalhando em atividades domiciliares. O tipo da lesão mais comum foi contusa, em mais de um local do corpo. Este estudo aponta a importância de se conhecer o perfil da mulher agredida, para orientação de políticas públicas preventivas nesta população.
Defining the design barriers to adaptive clothing
Authors: Hall Martha L , Kosinski Kelsey
Published: January 2023

The purpose of this research is to identify and organize the design barriers of adaptive clothing in order to increase its market availability. Adaptive clothing is garments designed specifically for people living with disabilities, endeavouring to increase quality of life and independence. Despite the benefits, adaptive clothing is not widely available for purchase because very little house-hold-name brands sell it, typically only available online from small companies. The aim of this research is to facilitate the identification of the design barriers by designing and testing apparel, which addresses the clothing related needs of an individual living with Down syndrome. By identifying the design barriers, this research produces a novel approach to product design. The new practice, titled Design for Inclusivity, is an interdisciplinary research method, not only focusing on user-centered design to satisfy clothing related needs of people living with disabilities, but also creating inclusion by marketing to both people living with and without disabilities.
A comprehensive study on the effect of different seam parameters on woven fabrics
Authors: Uzun Muhammet , Gümüştaş Başak , Huşçe Hilal , Kabir Md Humayun , Kanberoğlu Emine
Published: January 2023

Nowadays, in the ready-made clothing industry, woven fabrics of different construction and pattern are used to a greater extent. Low sewing performance is a common phenomenon that is observed in these fabrics. This study aims to define the dominant parameters such as fiber, yarn, fabric structure, sewing thread, and sewing needle, which affect sewing performance and cause sewing defects, and to examine their effects on sewing quality. The most frequently used needle and sewing thread, fabric weighing under 200g/m2 which may cause a problem in sewing are selected for this study. Effective sewing parameters and combinations that can work most efficiently with different fabric properties are suggested accordingly. The study aims to determine and minimize the damage caused by sewing needles on thin fabrics.
Similarities and differences in consumers' choices of swimwear between Brazil and Israel
Authors: Pedro Yael , Sandes Fábio Shimabukuro
Published: January 2023

Purpose: This study aims to verify whether cultural aspects influence consumers’ product appraisal by analyzing how consumers from two countries choose products from designers with diverse cultural backgrounds. Design/Methodology: A questionnaire was applied, with 321 female respondents (217 from Brazil, 104 from Israel) who chose swimsuits from two different styles (“Classic” and “Trendy”) in four different options: bikini, one-piece, solid colors, and print options. Findings: Both countries preferred design from the same cultural background, but while Brazilian respondents opted mostly for designs by Brazilian designers, Israeli respondents chose more openly. Israeli respondents presented a much higher restriction on bikini models than one-pieces, while Brazilians presented the opposite type of rejection. Research implications: The results suggest that cultural aspects influence consumers’ choices in product appraisal, as respondents tend to choose designs made under the same cultural influence. Originality/value: This paper is the first to compare consumers’ choices in a cross-cultural context, applying the same questionnaire in two countries on different continents.
Research regarding new sustainable methods of garment pattern drafting
Authors: Marin Irina Elena
Published: January 2023

Based on the present need for change in the garment industry, multiple solutions for waste reducing have been established. It has become common to associate fashion with pollution, and this association has its roots in the statistic data that constantly raise red flags regarding the negative impact that our everyday textiles have over the planet. The following paper has been developed under the strict rules that the zero waste pattern drafting has, keeping in mind the design and product finishing matters. Further possible issues have been taken into account whilst defining and shaping the pattern pieces, aiming to obtain a product that is framed by proper aesthetics, fit, zero waste drafting technique and quality finishing. The way in which the waste management can be kept under control from the pattern drafting step is the key to gaining a sustainable clothing item. Apart from the fabric scraps, the time and energy needed for sampling can also be optimized, by using the virtual prototyping opportunity. These two crucial elements, combined, led to garments that can last in time. The nexus of the garment manufacturing techniques that have increased in popularity lately has been elaborated in the following paper, following the process accordingly, shaping into a number of digital clothing items. The method used can be successfully implemented by clothing manufacturers that wish to adopt a healthy and non pollutive process.
An approach to design solutions for garments using a CAD system
Authors: Moniruzzaman Md. , Rita Afroza Akter , Oishe Saudia Haque
Published: January 2023

The making of patterns is the beginning of the cycle of designing garments. Pattern making is an accomplished technique requiring technical ability, flexibility for interpretation of design, and a realistic understanding of the construction of garments. It is a feature of bridge function between design and development. This is an effective and conservative approach that can be manipulated by a technique known as flat pattern designing to construct the pattern for various types. The most frequent issues of pattern making are following only Dart Manipulation or Added fullness or Contouring method rather than all at a time. If this practice of all methods can compare with the CAD system the output would be more accurate to resolve the issues of miss fit, imbalance, and so on. Another result of the research shows that the designs are substantially constructed without understanding that the design is based on certain concepts and structures. The principles of pattern making consist of three most prominent methods namely Dart Manipulation, Added fullness, and Contouring. This is essential to know for making flat patterns and alterations according to individual designs. When we perceive the basic principles of pattern making and modification we produce any kind of design without affecting the original pattern size and shape thus we can meet the desired fit and balance. This study will demonstrate a way of applying three pattern-making methods to garments manually as well as CAD. These patterns can be manipulated and changed into shapes through the slash-spread technique. The slash-spread technique is easy to understand as it clearly illustrates the changes taking place. The outcome of this study will impact the new upcoming fashion industry and also the garment industry.
Investigation of garments fit for 20-30 aged Bangladeshi men’s
Authors: Nizam Eanamul Haque , Ujevic Darko , Khan Ayub Nabi
Published: January 2023

In this research the author tries to find out the traditional pattern making error comparing with 3D scanning measurement data to test fit and balance of make to order garments. At first the author select only men’s classic shirt to evaluate the traditional error for make to order item. After analyzing BG-WG and Bust/Chest typical body sizes are selected to develop block to test factor affecting on fit and balance on real body with garment scanning. Using pattern block of typical body shape the author tries to find out the fit for regular shirt in order to find balanced and fit garment for real bodies. After investigating the pattern block and shape evaluate the adaption fit and balance for each customer. All the resulted data can be implementing by any fashion designer and pattern maker to overcome the traditional error to ensure the fit criteria for the customer.
Sustainable packaging - a roadmap for Indian fashion and apparel industry
Authors: Varma Indrila Goswami , Chanana Bhawana
Published: January 2023

Environmental sustainability has become a key managerial issue for most industries and in particular fashion industry looking into its scandalous reputation for being one of the largest contributors to global pollution. A critical aspect when looking at sustainability in supply chains of fashion is, Packaging. A big part of the waste crisis is the result of packaging, which the fashion industry is using ever more in this age of cheap fashion and online retail across the world. This paper attempts to trace the initiatives taken by Indian apparel manufacturers and retailers in creating sustainable packaging and trace the Life cycle Management of the packaging wastes. The objective of the paper is to create a sustainability road map for the fashion industry in India in terms of packaging by assessing the various global initiatives being taken in closing the loop on recovering material value. The methodology adopted is mainly review of literature and unstructured personal interviews with retail professionals from the field of beauty, FMCG and fashion.
BASTA: Campanha de fotografia e design pelo combate à misoginia
Authors: Garcia Lima Paula , Brum Michele
Published: January 2023

Misoginia são ações praticadas em nossa sociedade muito antes de ser uma palavra, de ter um conceito.Refere-se a condutas de inferiorização e de ódio contra as mulheres, advindas de uma sociedade patriarcal, que impõe padrões e valores restritivos a elas. Tendo isso em vista o presente texto - que é parte de um trabalho de conclusão de curso -  tem por finalidade descrever a criação da campanha BASTA, composta de cartazes que alertam para as referidas situações. Assim sendo, o presente texto está dividido por uma abordagem teórica e um relato da prática de criação dos cartazes. Na primeira parte, os principais conceitos abordados foram misoginia e lugar de fala; no segundo momento, quando da exposição, da confecção dos cartazes, a maior atenção foi dada para as fotografias, elementos de maior destaque  para expressão do significado pretendido. Por fim, defende-se a pertinência deste trabalho por trazer a temática para o interior do ambiente universitário - importante espaço de reflexão da sociedade - dentro de um curso de Design, cujos produtos visuais impactam na construção de hábitos e comportamentos.
Analysis of biofilm formation in nosocomial Stenotrophomonas maltophilia isolates collected in Bulgaria: An 11-year study (2011–2022)
Authors: Strateva Tanya , Trifonova Angelina , Sirakov Ivo , Borisova Dayana , Stancheva Mikaela , Keuleyan Emma , Setchanova Lena , Peykov Slavil
Published: January 2023

The present study aimed to explore the genotypic and phenotypic characteristics of biofilm formation in Bulgarian nosocomial Stenotrophomonas maltophilia isolates (n = 221) during the period 2011–2022, by screening for the presence of biofilm-associated genes (BAG) (spgM, rmlA and rpfF), their mutational variability, and assessment of the adherent growth on a polystyrene surface. The methodology included: PCR amplification, whole-genome sequencing (WGS) and crystal violet microtiter plate assay for biofilm quantification. The overall incidence of BAG was: spgM 98.6%, rmlA 86%, and rpfF 66.5%. The most prevalent genotype was spgM+/rmlA+/rpfF+ (56.1%), followed by spgM+/rmlA+/rpfF- (28.5%), and spgM+/rmlA-/rpfF+ (9.5%), with their significant predominance in lower respiratory tract isolates compared to those with other origin (P < 0.001). All strains examined were characterized as strong biofilm producers (OD550 from 0.224 ± 0.049 to 2.065 ± 0.023) with a single exception that showed a weak biofilm-forming ability (0.177 ± 0.024). No significant differences were observed in the biofilm formation according to the isolation source, as well as among COVID-19 and non-COVID-19 isolates (1.256 ± 0.028 vs. 1.348 ± 0.128, respectively). Also, no correlation was found between the biofilm amounts and the corresponding genotypes. WGS showed that the rmlA accumulated a larger number of variants (0.0086 per base) compared to the other BAG, suggesting no critical role of its product to the biofilm formation. Additionally, two of the isolates were found to harbour class 1 integrons (7-kb and 2.6-kb sized, respectively) containing sul1 in their 3′ conservative ends, which confers sulfonamide resistance. To the best of our knowledge, this is the first study on S. maltophilia biofilm formation in Bulgaria, which also identifies novel sequence types (ST819, ST820 and ST826). It demonstrates the complex nature of this adaptive mechanism in the multifactorial pathogenesis of biofilm-associated infections.
PENERAPAN INSYA’ MUWAJJAH DALAM PEMBELAJARAN BAHASA ARAB
Authors: Nisa’ Khoirun , Khotimah Isnol , Ulum Moh.
Published: January 2023

Penerapan insya’ muwajjah dalam pembelajaran bahasa Arab adalah salah satu metode yang diterapkan di Pondok Pesantren Al-mashduqiah Kraksaan Probolinggo. Maksud dari penerapan ini adalah sebagai cara guru dalam mengajar bahasa Arab khususnya kemampuan mengarang siswa secara terbimbing, siswa dibimbing melalu buku ajar yaitu kitab “Durusul lughah Al-Arabiyah” beserta media lainnya. Guru bertindak langsung dalam penerapan ini, tujuannya agar siswa aktif dalam menulis dan menghafal kosa kata Arab. Oleh karena itu maka penelitian ini bertujuan untuk mendeskripsikan penerapan insya’ muwajjah dalam pembelajaran bahasa Arab siswa JMA Pondok Pesantren Al-mashduqiah.Riset yang digunakan merupakan riset lapangan yang bertabiat deskriptif kualitatif. Guru bahasa Arab dan siswa JMA Pondok Pesantren Al-mashduqiah Kraksaan Probolinggo selaku subjek dalam riset ini, sedangkan insya’ muwajjah dalam pembelajaran bahasa Arab adalah objek penelitiannya. Observasi, wawancara, dan dokumentasi merupakan metode untuk mengumpulkan data.Hasil dari penelitian ini adalah 1)Menghafal kosa kata Arab khususnya pada benda sekitar  2)Siswa sesering mungkin  membuat jumlah mufidah sebelum masuk ke maharah kitabah 3)Menulis sesuatu yang berkaitan dengan kegiatan sehari-hari agar menjadi kebiasaan yang baik walaupun sedikit. 4)Siswa membiasakan menulis kalimat sederhana seminggu sekali adalah target seorang Guru.