bluuebunny/crossref_metadata_2025 huggingface dataset:
The coupled Boussinesq equation and its Darboux transformation on the time–space scale
Authors: Huang Xiaoqian , Zhang Yong , Dong Huanhe
Published: December 2022

Gel’fand-Dikii (GD) formalism is an approach for generating integrable systems in terms of fractional powers of the δ differential operator. In this paper, it extends the GD formalism associated with the third-order δ differential operator L to the time scale. Then, the coupled Boussinesq equation on the time–space scale is given by taking special values, and it can be reduced on different time–space scales. Moreover, the exact solutions of the coupled Boussinesq equation on the time–space scale and the classical Boussinesq equation are constructed via employing the extensions of the Darboux theorem and Crum theorem on the time scale.
Preclinical modeling of low energy X-rays radiological burn: Dosimetry study by monte carlo simulations and EPR spectroscopy
Authors: Guillou Manon , L’Homme Bruno , Trompier François , Gruel Gaëtan , Prezado Yolanda , Dos Santos Morgane
Published: December 2022

Interventional radiology has grown considerably over the last decades and become an essential tool for treatment or diagnosis. This technique is mostly beneficial and mastered but accidental overexposure can occur and lead to the appearance of deterministic effects. The lack of knowledge about the radiobiological consequences for the low-energy X-rays used for these practices makes the prognosis very uncertain for the different tissues. In order to improve the radiation protection of patients and better predict the risk of complications, we implemented a new preclinical mouse model to mimic radiological burn in interventional radiology and performed a complete characterization of the dose deposition. A new setup and collimator were designed to irradiate the hind legs of 15 mice at 30 Gy in air kerma at 80 kV. After irradiation, mice tibias were collected to evaluate bone dose by Electron Paramagnetic Resonance (EPR) spectroscopy measurements. Monte Carlo simulations with Geant4 were performed in simplified and voxelized phantoms to characterize the dose deposition in different tissues and evaluate the characteristics of secondary electrons (energy, path, momentum). 30 mice tibias were collected for EPR analysis. An average absorbed dose of 194.0 ± 27.0 Gy was measured in bone initially irradiated at 30 Gy in air kerma. A bone to air conversion factor of 6.5 ± 0.9 was determined. Inter sample and inter mice variability has been estimated to 13.9%. Monte Carlo simulations shown the heterogeneity of the dose deposition for these low X-rays energies and the dose enhancement in dense tissue. The specificities of the secondary electrons were studied and showed the influence of the tissue density on energies and paths. A good agreement between the experimental and calculated bone to air conversion factor was obtained. A new preclinical model allowing to perform radiological burn in interventional radiology-like conditions was implemented. For the development of new preclinical radiobiological model where the exact knowledge of the dose deposited in the different tissues is essential, the complementarity of Monte Carlo simulations and experimental measurements for the dosimetric characterization has proven to be a considerable asset.
Climate overrides fencing and soil mineral nutrients to affect plant diversity and biomass of alpine grasslands across North Tibet
Authors: Guo Chenrui , Wesche Karsten , Mărgărint Mihai Ciprian , Nowak Arkadiusz , Dembicz Iwona , Wu Jianshuang
Published: December 2022

Introduction

Overgrazing and warming are thought to be responsible for the loss of species diversity, declined ecosystem productivity and soil nutrient availability of degraded grasslands on the Tibetan Plateau. Mineral elements in soils critically regulate plant individual’s growth, performance, reproduction, and survival. However, it is still unclear whether plant species diversity and biomass production can be improved indirectly via the recovery of mineral element availability at topsoils of degraded grasslands, via grazing exclusion by fencing for years.

Methods

To answer this question, we measured plant species richness, Shannow-Wiener index, aboveground biomass, and mineral element contents of Ca, Cu, Fe, Mg, Mn, Zn, K and P at the top-layer (0 - 10 cm) soils at 15 pairs of fenced vs grazed matched sites from alpine meadows (n = 5), alpine steppes (n = 6), and desert-steppes (n = 4) across North Tibet.

Results

Our results showed that fencing only reduced the Shannon-Wiener index of alpine meadows, and did not alter aboveground biomass, species richness, and soil mineral contents within each grassland type, compared to adjacent open sites grazed by domestic livestock. Aboveground biomass first decreased and then increased along with the gradient of increasing Ca content but did not show any clear relationship with other mineral elements across the three different alpine grassland types. More than 45% of the variance in plant diversity indices and aboveground biomass across North Tibet can be explained by the sum precipitation during plant growing months. Structural equation modelling also confirmed that climatic variables could regulate biomass production directly and indirectly via soil mineral element (Ca) and plant diversity indices.

Discussion

Overall, the community structure and biomass production of alpine grasslands across North Tibet was weakly affected by fencing, compared to the robst climatic control. Therefore, medium-term livestock exclusion by fencing might have limited contribution to the recovery of ecosystem structure and functions of degraded alpine grasslands.
Transcriptional profiling of defense responses to Botrytis cinerea infection in leaves of Fragaria vesca plants soil-drenched with β-aminobutyric acid
Authors: Badmi Raghuram , Tengs Torstein , Brurberg May Bente , Elameen Abdelhameed , Zhang Yupeng , Haugland Lisa Karine , Fossdal Carl Gunnar , Hytönen Timo , Krokene Paal , Thorstensen Tage
Published: December 2022

Grey mold caused by the necrotrophic fungal pathogen Botrytis cinerea can affect leaves, flowers, and berries of strawberry, causing severe pre- and postharvest damage. The defense elicitor β-aminobutyric acid (BABA) is reported to induce resistance against B. cinerea and many other pathogens in several crop plants. Surprisingly, BABA soil drench of woodland strawberry (Fragaria vesca) plants two days before B. cinerea inoculation caused increased infection in leaf tissues, suggesting that BABA induce systemic susceptibility in F. vesca. To understand the molecular mechanisms involved in B. cinerea susceptibility in leaves of F. vesca plants soil drenched with BABA, we used RNA sequencing to characterize the transcriptional reprogramming 24 h post-inoculation. The number of differentially expressed genes (DEGs) in infected vs. uninfected leaf tissue in BABA-treated plants was 5205 (2237 upregulated and 2968 downregulated). Upregulated genes were involved in pathogen recognition, defense response signaling, and biosynthesis of secondary metabolites (terpenoid and phenylpropanoid pathways), while downregulated genes were involved in photosynthesis and response to auxin. In control plants not treated with BABA, we found a total of 5300 DEGs (2461 upregulated and 2839 downregulated) after infection. Most of these corresponded to those in infected leaves of BABA-treated plants but a small subset of DEGs, including genes involved in ‘response to biologic stimulus‘, ‘photosynthesis‘ and ‘chlorophyll biosynthesis and metabolism’, differed significantly between treatments and could play a role in the induced susceptibility of BABA-treated plants.
Unleashing the power within short-read RNA-seq for plant research: Beyond differential expression analysis and toward regulomics
Authors: Tu Min , Zeng Jian , Zhang Juntao , Fan Guozhi , Song Guangsen
Published: December 2022

RNA-seq has become a state-of-the-art technique for transcriptomic studies. Advances in both RNA-seq techniques and the corresponding analysis tools and pipelines have unprecedently shaped our understanding in almost every aspects of plant sciences. Notably, the integration of huge amount of RNA-seq with other omic data sets in the model plants and major crop species have facilitated plant regulomics, while the RNA-seq analysis has still been primarily used for differential expression analysis in many less-studied plant species. To unleash the analytical power of RNA-seq in plant species, especially less-studied species and biomass crops, we summarize recent achievements of RNA-seq analysis in the major plant species and representative tools in the four types of application: (1) transcriptome assembly, (2) construction of expression atlas, (3) network analysis, and (4) structural alteration. We emphasize the importance of expression atlas, coexpression networks and predictions of gene regulatory relationships in moving plant transcriptomes toward regulomics, an omic view of genome-wide transcription regulation. We highlight what can be achieved in plant research with RNA-seq by introducing a list of representative RNA-seq analysis tools and resources that are developed for certain minor species or suitable for the analysis without species limitation. In summary, we provide an updated digest on RNA-seq tools, resources and the diverse applications for plant research, and our perspective on the power and challenges of short-read RNA-seq analysis from a regulomic point view. A full utilization of these fruitful RNA-seq resources will promote plant omic research to a higher level, especially in those less studied species.
Sugarcane bagasse ash as fertilizer for soybeans: Effects of added residues on ash composition, mineralogy, phosphorus extractability and plant availability
Authors: Dombinov Vitalij , Herzel Hannes , Meiller Martin , Müller Felix , Willbold Sabine , Zang Joachim W. , da Fonseca-Zang Warde A. , Adam Christian , Klose Holger , Poorter Hendrik , Jablonowski Nicolai D. , Schrey Silvia D.
Published: December 2022

Sugarcane bagasse is commonly combusted to generate energy. Unfortunately, recycling strategies rarely consider the resulting ash as a potential fertilizer. To evaluate this recycling strategy for a sustainable circular economy, we characterized bagasse ash as a fertilizer and measured the effects of co-gasification and co-combustion of bagasse with either chicken manure or sewage sludge: on the phosphorus (P) mass fraction, P-extractability, and mineral P phases. Furthermore, we investigated the ashes as fertilizer for soybeans under greenhouse conditions. All methods in combination are reliable indicators helping to assess and predict P availability from ashes to soybeans. The fertilizer efficiency of pure bagasse ash increased with the ash amount supplied to the substrate. Nevertheless, it was not as effective as fertilization with triple-superphosphate and K2SO4, which we attributed to lower P availability. Co-gasification and co-combustion increased the P mass fraction in all bagasse-based ashes, but its extractability and availability to soybeans increased only when co-processed with chicken manure, because it enabled the formation of readily available Ca-alkali phosphates. Therefore, we recommend co-combusting biomass with alkali-rich residues to increase the availability of P from the ash to plants.
Impacts of drought and elevated temperature on the seeds of malting barley
Authors: Nagel Manuela , Arc Erwann , Rajjou Loïc , Cueff Gwendal , Bailly Marlene , Clément Gilles , Sanchez-Vicente Inmaculada , Bailly Christophe , Seal Charlotte E. , Roach Thomas , Rolletschek Hardy , Lorenzo Oscar , Börner Andreas , Kranner Ilse
Published: December 2022

High seed quality is key to agricultural production, which is increasingly affected by climate change. We studied the effects of drought and elevated temperature during seed production on key seed quality traits of two genotypes of malting barley (Hordeum sativum L.). Plants of a “Hana-type” landrace (B1) were taller, flowered earlier and produced heavier, larger and more vigorous seeds that resisted ageing longer compared to a semi-dwarf breeding line (B2). Accordingly, a NAC domain-containing transcription factor (TF) associated with rapid response to environmental stimuli, and the TF ABI5, a key regulator of seed dormancy and vigour, were more abundant in B1 seeds. Drought significantly reduced seed yield in both genotypes, and elevated temperature reduced seed size. Genotype B2 showed partial thermodormancy that was alleviated by drought and elevated temperature. Metabolite profiling revealed clear differences between the embryos of B1 and B2. Drought, but not elevated temperature, affected the metabolism of amino acids, organic acids, osmolytes and nitrogen assimilation, in the seeds of both genotypes. Our study may support future breeding efforts to produce new lodging and drought resistant malting barleys without trade-offs that can occur in semi-dwarf varieties such as lower stress resistance and higher dormancy.
Living grass mulching improves soil enzyme activities through enhanced available nutrients in citrus orchards in subtropical China
Authors: Wang Na , Li Le , Gou Mengmeng , Jian Zunji , Hu Jianwen , Chen Huiling , Xiao Wenfa , Liu Changfu
Published: December 2022

Living grass mulching (LGM) is an important orchard floor management that has been applied worldwide. Although LGM can effectively enhance soil nutrient availability and fertility, its effects on microbial-mediated soil nutrient cycling and main drivers are unclear. Meanwhile, the variation of enzyme activities and soil nutrient availability with LGM duration have been rarely studied. This study aims to explore the effects of mulching age and soil layer on enzyme activities and soil nutrients in citrus orchards. In this study, three LGM (Vicia villosa) treatments were applied, i.e., mulching for eight years, mulching for four years, and no mulching (clean tillage). Their effects on the enzyme activities and soil nutrients were analyzed in different soil layers of citrus orchards in subtropical China, i.e., 0-10, 10-20, and 20-40 cm. Compared to clean tillage, mulching for four years had fewer effects on enzyme activities and soil nutrients. In contrast, mulching for eight years significantly increased available nitrogen (N), phosphorus (P) nutrients, β-glucosidase, and cellobiohydrolase activities in the soil layer of 0-20 cm. In the soil layer of 0-40 cm, microbial biomass carbon (C), N, P, N-acetylglucosaminidase, leucine aminopeptidase, and acid phosphatase activities also increased (P < 0.05). Mulching for eight years significantly promoted C, N, and P-cycling enzyme activities and total enzyme activities by 2.45-6.07, 9.29-54.42, 4.42-7.11, and 5.32-14.91 times, respectively. Redundancy analysis shows that mulching treatments for eight and four years had soil layer-dependent positive effects on soil enzyme activities. Microbial C and P showed the most significant positive correlation with enzyme activities, followed by moisture content, organic C, and available N (P < 0.05). Available nutrients contributed almost 70% to affect enzyme activities significantly and were the main drivers of the enzyme activity variation. In summary, LGM could improve soil enzyme activities by increasing available nutrients. The promotion effect was more significant under mulching for eight years. Therefore, extending mulching age and improving nutrient availability are effective development strategies for sustainable soil management in orchard systems. Our study can provide valuable guidelines for the design and implementation of more sustainable management practices in citrus orchards.
The impact of stress, recovery and coping on burnout symptoms of young elite table-tennis players: A prospective multilevel study
Authors: Martinent Guillaume , Cece Valérian , Guillet-Descas Emma
Published: December 2022

Objective

The aim of the present study was to explore the role of stress, recovery, and coping on table-tennis athlete burnout symptoms in considering both the roles of individual and contextual (training center) factors.

Methods

One hundred and fifty-nine youth elite table-tennis players (Mage = 14.07, SD = 2.13) involved in 15 intensive training centers completed self-report questionnaires and socio-demographic data.

Results

When time 1 (T1) levels 1 (individual) and 2 (training group, contextual factor) stress, recovery, and coping were simultaneously entered as predictors of each of the three burnout symptoms (physical and emotional exhaustion, sport devaluation, reduced accomplishment) at T2 (controlling for levels 1 and 2 burnout at T1), the results of multilevel analyses revealed that: (a) T1 level 1 recovery significantly negatively predicted T2 reduced accomplishment (β = −0.23, p = 0.03); (b) T1 level 2 disengagement-oriented coping significantly negatively predicted T2 reduced accomplishment (β = −0.71, p = 0.03); and (c) T1 level 2 task-oriented coping marginally significantly positively predicted T2 physical and emotional exhaustion (β = 0.99, p = 0.06).

Conclusion

Results of the present study provided evidence for the usefulness to disentangle the variances attributable to the individual (level 1) and contextual (level 2; training group) levels of the predictors (recovery, stress and coping) of athlete burnout. Moreover, rather than examining the antecedent role of stress on athlete burnout, it could be particularly fruitful to explore theoretical constructs able to annihilate the maladaptive effects of chronic stress such as coping and recovery.
Understanding older adults’ attitudes toward mobile and wearable technologies to support health and cognition
Authors: Fowe Ibukun E. , Boot Walter R.
Published: December 2022

The use of technology to facilitate remote patient monitoring and virtual care is desirable due to the challenges of providing healthcare during the COVID-19 pandemic and the need for more efficient and effective methods to care for the expanding older adult population. Further, the collection and sharing of patient generated health data (PGHD) through these technologies holds promise with respect to improving outcomes and reducing the cost of care by facilitating the early detection and treatment of cognitive and health problems. Despite the potential benefits of these technologies, their promise might be hampered by low rates of acceptance and adoption among older adults. In an online survey, we assessed community-dwelling older adults’ (N = 92) attitudes towards the use of wearable and mobile technologies for (1) predicting cognitive decline, (2) assisting with adherence to healthy activities, and (3) collecting self-report data to understand current and predict future health states. Participants generally agreed hypothetical technology solutions would be useful (M = 4.20, SD = 0.70 on a 1–5 agreement scale; 5 = “strongly agree”), that they were interested in learning more about these technologies (M = 4.04, SD = 0.74), and that they would be willing to adopt these technologies (M = 3.83, SD = 0.93), though attitudes varied. Although participants were generally positive toward these technologies, they were relatively neutral in terms of their agreement that privacy of generated data was a concern (M = 2.92, SD = 1.02). Privacy concerns were associated with lower interest and willingness to adopt. More positive general technology attitudes and higher mobile device proficiency were associated with greater acceptance and willingness to adopt these technologies. Finally, poorer self-rated health was related to negative attitudes toward these technologies. These findings highlight barriers and potential targets for intervention to increase uptake of these and similar technologies among older adults who may be reluctant to adopt remote monitoring technologies.
A study of college students’ perceptions of utilizing automatic speech recognition technology to assist English oral proficiency
Authors: Liu Jiaxin , Liu Xianghu , Yang Chuan
Published: December 2022

For English as a Foreign Language (EFL) students, automatic speech recognition (ASR) technology is the most potential assistant tool to help them improve their spoken English ability. The primary purpose of this study is to investigate learners’ perceptions towards ASR technology after it is applied to traditional classrooms. This study selected 249 English majors from a university in Northeastern China as samples and divided them into a control group consisting of 124 students and an experimental group including 125 students. The participants of two groups used ASR technology in the process of oral practice, and the experimental group also added teacher’s guidance compared with the control group. The teacher gives more detailed instruction in speaking based on the scores provided by ASR technology. Participants needed to complete relevant questionnaires and learning reflective journals during the experiment. The results of the study showed that both participants and instructors held positive and satisfactory attitudes towards the potential of ASR in oral training and believed that the technology could meet many of their needs such as the scoring system to help them more intuitively understand the real speaking level. The findings of this paper will give some implications to oral English teaching in the future.
Coworking spaces vs. home: Does employees' experience of the negative aspects of working from home predict their intention to telework in a coworking space?
Authors: Lescarret Colin , Lemercier Céline , Le Floch Valérie
Published: December 2022

In this study, we investigated the determinants of employees' intention to telework in a coworking space, with the assumption that employees' experience with the negative aspects of teleworking from home would impact their intention to telework in a coworking space in the future. A sample of 268 French teleworkers answered an online questionnaire measuring their experience of several negative aspects of teleworking from home (e.g., perceived social isolation), and their opinion toward teleworking in a coworking space (perceived usefulness, perceived feasibility, attitude and behavioral intention). Results indicate that perceived social isolation and perceived lack of working comfort when working from home directly impacted how useful participants perceived teleworking in a coworking space to be, and indirectly their intention to telework in a coworking space in the future. Budget, management agreement and job compatibility were, however, identified as factors mitigating participants' intention to telework in a coworking space, even if perceived as potentially beneficial.
Bibliometric and visual analysis of cardiovascular diseases and COVID-19 research
Authors: Wei Namin , Xu Yan , Wang Huan , Jia Qiulei , Shou Xintian , Zhang Xuesong , Zhang Nan , Li Ya'nan , Zhai Huaqiang , Hu Yuanhui
Published: December 2022

Background

The global community has been affected by the coronavirus disease 2019 (COVID-19), which emerged in December 2019. Since then, many studies have been conducted on cardiovascular diseases (CVDs) and COVID-19. The aim of this study was to perform a bibliometric and visual analysis of the published relationship between CVDs and COVID-19.

Methods

1,890 publications were retrieved from the Web of Science Core Collection database on January 5, 2022. Microsoft Office Excel and CiteSpace were then used to carry out scientometric analysis on the relevant literature according to seven aspects: document type, countries/regions, institutions, authors, journals, references, and keywords.

Results

The research on CVDs and COVID-19 is currently in a period of rapid development, with China, USA, England, and Italy leading the field. There is active cooperation between most countries and institutions. Harvard Medical School stands out among the many institutions not only for the largest number of publications, but also for their high quality. Banerjee A, Solomon SD and Narula J are three representative authors in this field. Frontiers in Cardiovascular Medicine was the journal with the highest number of published studies, and The Lancet was the most cited journal. Two documents with a high degree of significance in this field were identified. Popular research topics in this field are specific diseases, such as acute coronary syndrome and heart failure; pathogenesis related to ACE2, insulin resistance and pericyte; the specific therapeutic drug chloroquine; and clinical characteristics, physical activity, and mental health. ACE2 and NF-κB will be the focus of future research.

Conclusions

This study provides useful information for the research of CVDs and COVID-19, including potential collaborators, popular research topics, and a reference for more extensive and in-depth research in the future.
At-home disposal practices of used insulin needles among patients with diabetes in China: A single-center, cross-sectional study
Authors: Tu Haixia , Lu Xueqin , Wang Jialu , Sheng Zhiqiong , Liu Danman , Li Jufang , Sun Caixia , Yin Zhiqin
Published: December 2022

Background

Most insulin injections for people with diabetes are administered at home, thus generating many used needles. Unsafe disposal of these at-home needles can lead to needle stick injuries, blood-borne disease transmission, and environmental contamination. Previous studies have shown varying results on the prevalence of and factors associated with safe sharps disposal practices of people with diabetes.

Objective

To assess the prevalence of and the factors associated with the safe disposal of used insulin needles among patients with diabetes.

Methods

We collected data from 271 insulin-using patients at a tertiary care hospital in China. A self-designed instrument was used to assess sociodemographic data, disease- and treatment-related characteristics, sharps disposal practices, education on diabetes self-management and sharps disposal, and awareness of the potential risks associated with unsafe sharps disposal. Multivariate logistic regression analysis was used to explore factors associated with safe sharps disposal practices.

Results

Only 10.3% (28/271) of participants disposed of used at-home insulin needles in a safe manner, and 14.8% (45/271) of participants had received previous instruction on sharps disposal. Previous sharps disposal instruction (AOR = 4.143, 95% CI = 1.642–10.450) and awareness of the risk of blood-borne pathogen transmission (AOR = 3.064, 95% CI = 1.332–7.046) were associated with safe disposal of used insulin needles.

Conclusion

In our study, the prevalence of safe sharps disposal practices was low, and a minority of respondents had received previous instruction on sharps disposal. Participants who had previously received instruction and were aware of the risk of blood-borne pathogen transmission were more likely to handle sharps safely. Our study findings suggest that health care professionals should pay attention to sharps disposal practices of patients with diabetes and conduct diabetes education programs that include information on safe sharps disposal methods and potential hazards of unsafe sharps disposal.
Engaging Community Health Centers to understand their perceptions and interest in longitudinal cohort research on diabetes mellitus in Native Hawaiian communities: Initial insights from the Waimānalo community
Authors: Mau Marjorie K. Leimomi Mala , Baumhofer Merritt Nicole Kau'i , Werner Kamuela , Oneha Mary Frances
Published: December 2022

Introduction

Despite decades of research on diabetes mellitus (DM) and other health disparities affecting Native Hawaiian and Pacific Islander (NHPI) populations, little is known about the disease mechanisms that underlie these health disparities. Ideally, a longitudinal cohort study is one of the best research design tools to examine underlying mechanisms of disease in health disparity conditions such as DM. The study purpose is to understand the perspectives and insights of people (n = 29) living in NHPI communities about conducting longitudinal cohort studies aimed at understanding mechanisms of health disparities in NHPI populations.

Methods

All interviews were audio-recorded, transcribed and de-identified into written transcripts for thematic content analysis.

Results

Four major themes emerged: 1) Diabetes and other health disparities is a community priority because these diseases touch nearly everyone; 2) Cohort-type research and its outcomes should extend beyond data collection to include data sharing using a cultural context approach; 3) Cohort-type research can directly benefit everyone, especially youth, through education on new, locally-derived knowledge; 4) A longterm benefit of cohort-type research should be to support “generational change” in the community.

Discussion

In summary, potential “cohort-type research” (a.k.a. longitudinal cohort study designs) was perceived as a worthy endeavor because health disparities, such as DM, affects nearly everyone in the community. Cohort-type research is important to NHPI communities as it holds promise for impacting “generational change” on health and wellbeing through the sharing of new community-derived knowledge.
Association between Helicobacter pylori infection and non-alcoholic fatty liver disease for Asian and non-Asian population: A systematic review and meta-analysis
Authors: Ma Zhiyuan , Chu Xiajing , Yan Xiang , Wang Wenjin
Published: December 2022

Background

Several studies have revealed a positive correlation between a Helicobacter pylori (HP) infection and the risk of non-alcoholic fatty liver disease (NAFLD). This meta-analysis was conducted to explore further the relationship between HP infection and NAFLD in the Asian and non-Asian populations.

Methods

Relevant studies published from inception to July 22, 2021, in the following databases: PubMed, EMBASE, the Cochrane library, and Web of Science were comprehensively searched. The odds ratio (OR) and hazard ratio (HR) with a 95% confidence interval (95%CI) were pooled by the random-effects model or fixed-effects model. Additionally, subgroup and sensitivity analyses were performed. The funnel plot and the Egger test were used to estimate publication bias.

Results

This meta-analysis included 25 studies involving 107,306 participants. Positive associations between HP infection and NAFLD were found both for the Asian (OR = 1.30, 95% CI: 1.13–1.49, P < 0.01; I2 = 94.30%, P < 0.01) and non-Asian populations (OR = 1.42, 95% CI: 1.04–1.94, P = 0.03; I2 = 44.90%, P = 0.09). Moreover, similar results were observed in the Asian female group (OR = 1.31, 95% CI: 1.17–1.46, P < 0.01; I2 = 46.30%, P = 0.07) but not for the Asian male group. Subgroup analyses for the Asian population showed that there were differences in the association among NAFLD diagnosis methods (P < 0.01) and the study design (P < 0.01). However, subgroup and sensitivity analyses results showed that the association for the non-Asian population was not stable enough.

Conclusions

The data obtained in this systematic review and meta-analysis suggested that an HP infection was associated with an increased risk of NAFLD for Asian and non-Asian populations. However, the association was not found for Asian males. Further studies are required to establish the causal association, especially for the non-Asian population.

Systematic review registration

Identifier: CRD42021266871.
Perceived barriers to accessing physical therapy services in Florida among individuals with low back pain
Authors: Hanney W.J. , Munyon M.D. , Mangum L.C. , Rovito M.J. , Kolber M.J. , Wilson A.T.
Published: December 2022

Background

Low back pain (LBP) affects up to 84% of adults and physical therapy (PT) has been reported to be an effective approach to conservative care. For those individuals with LBP referred to PT, the decision to initiate and follow through with care is influenced by numerous factors. Currently, a paucity of evidence exists to identify barriers for patients with LBP to access PT care. Thus, the purpose of this study was to investigate perceived barriers influencing the decision to pursue PT care in the state of Florida.

Methods

A purposive survey was administered via Qualtrics ESOMAR. Screener questions ensured candidates had LBP, resided in Florida, and were referred to PT. Participants that met the screener questions were offered an opportunity to participate in the full survey. Once a participant completed the full survey, variables assessing LBP, access to PT services, and potential barriers were analyzed. A partial least squares structural equation model (PLS-SEM) via WarpPLS 7.0 was used to explore which of the perceived barriers had the greatest influence on whether an individual with LBP was able to pursue PT care.

Results

The conceptual framework that demonstrated the best fit of direct effects of potential barriers to accessing care included six independent exogenous latent variables: (a) unaware of a PT clinic near their home or work, (b) had children but no childcare for them, (c) had long PT sessions (e.g., 60 min), (d) had more than one PT session per week, (e) had fewer days active per week, and (f) exercised fewer times per day. Together the six variables explained 19% of the variance related to following through with care (R2 = 0.19).

Conclusions

The ability of an individual with LBP to access PT care in the state of Florida is multifactorial. There appears to be three broad factors that are the primary barriers, which include (a) the logistic ability (location and access to childcare) to attend PT treatment, (b) how much time is dedicated to the PT treatment, and (c) activity frequency of the individual seeking care. These findings support previous conceptual frameworks for predicting PT treatment. Practitioners and policy makers should consider these barriers when developing plans for conservative management of LBP in Florida.
The longer-term effects of IVF on offspring from childhood to adolescence
Authors: Hart R. J. , Wijs L. A.
Published: December 2022

It is well established that there are increased pregnancy-related complications for a woman who conceives through assisted reproductive treatment (ART). Furthermore, it is known that the risk to the child born is greater, believed to be related to prematurity and growth restriction. Studies have also reported epigenetic changes in the DNA of offspring conceived through ART. In addition, it is believed that they have a greater risk of congenital malformations, although some of these risks may relate to underlying infertility, rather than the ART treatment per se. As a result, it may be expected that there is a greater risk to the longer-term health of the child who is born from ART; however, evidence about the long-term health of children conceived through ART is reassuring. Even though, it is recognised that many of the studies in this field come with limitations. Low numbers of participants is one of the major limitations, which makes subgroup analyses for diverse types of ART, or diverse types of infertility, not feasible. Furthermore, studies are often limited by short follow-up periods because of the difficulty and costs involved in longitudinal study designs. In addition, the rapid changes over time in ART limit the generalisability and significance of long-term findings. Well-designed studies investigating the long-term health outcomes of ART-conceived offspring and the potential influences of various aspects of the ART procedure, as well as studies of the potential underlying epigenetic mechanisms, are imperative. Furthermore, conclusions from childhood hospitalisation data from the United Kingdom, the long-term follow-up and quality of life study from researchers in Melbourne, and the data published from the Western Australian Growing Up Healthy Study will go a long way to help reassure current and prospective parents who may require ART to conceive.
Transformation through learning: Education about, for, and as sustainability
Authors: Gajparia Jaya , Strachan Glenn , Leverton Kris
Published: December 2022

The United Nations foregrounds education as a means to achieving the Sustainable Development Goals (https://sdgs.un.org/goals). In this conceptual paper, we argue education must offer learning that is transformative to better prepare learners to respond to the current global challenges. We argue that the dominant educational approaches fall short of realizing learners' potential for transformation toward sustainability. Focusing on the region of Southeast Asia we draw on educator experiences working with and at the Green School (Indonesia) and United World College (Singapore) to map some of their educational successes and identify some of the key processes and conditions that have contributed to those successes. The potential that exists in the context of independent international schools maybe a relevant factor in their success. We see the lessons that can be learned from these examples as useful in other school contexts. We draw on three sequential pedagogical development phases of learning in engaging with sustainability: namely, Learning about Sustainability, Learning for Sustainability (LfS), and Learning as Sustainability. We argue that the third transformative learning phase, Learning as Sustainability (which also incorporates processes of learning about and for sustainability) offers the best fertile ground for engaging learners as active social change agents within and outside of the learning environment. We see these learning phases as all interconnected, dynamic, and fluid rather than a formulaic progression. This paper contributes to advancing schools toward a perspective on education that reflects an ecological approach toward sustainability and support educators to better integrate education as sustainability in their learning activities. It is worth mentioning that changes in the school that reflect an ecological approach does not guarantee that the experience of the learner will result in transformative Learning as Sustainability. Instead, it is our contention that attaining a clear understanding of these learning processes empowers educators to facilitate an environment by identifying and incorporating the necessary conditions required to inspire deep ecological transformation, thus increasing the potential to arrive at Learning as Sustainability.
Highland barley grain and soil surveys reveal the widespread deficiency of dietary selenium intake of Tibetan adults living along Yalung Zangpo River
Authors: Zhou Chenni , Xiao Ran , Li Mo , Wang Qi , Cong Wenfeng , Zhang Fusuo
Published: December 2022

Objective

In order to assess selenium (Se) flux through the soil-plant-human chain in Tibet plateau and explore the reason why local Tibetan adult residents from large scale agricultural production areas in Tibet lacked daily Se intake.

Methods

A total of 210 intact highland barley plants and their corresponding cultivated topsoil samples were collected in fields of 14 agricultural counties along Yalung Zangpo River and quantitative dietary data were collected from a cross-sectional survey using a cultural-specific food frequency questionnaire that contained all local Tibetan foods in 2020.

Results

The mean value of The estimated daily Se dietary intake by each participant was 17.1 ± 1.9 μg/day/adult, the Se concentration in topsoil and highland barley grain were 0.128 ± 0.015 mg/kg and 0.017 ± 0.003 mg/kg, respectively. Although highland barley was the first contributor of dietary Se in local adult residents (34.2%), the dietary Se intake provided by highland barley only about 10% of the EAR value (50 μg/day/adult) currently. A significantly positive relationship was determined between soil total Se content (STSe), available Se content (SASe) and highland barley grain Se content (GSe). The amount of Se in food system depends on a number of soil properties (TOC, pH, clay content, Fe/Mn/Al oxides), climate variables (MAP, MAT) and terrain factor (altitude).

Conclusion

To sum up, it can be inferred that the insufficient dietary Se intake of Tibetan adult population living along Yalung Zangbo River is mainly caused by the low Se content in highland barley grain, which was result from the low Se content in cultivated soil. In order to enable adult participants in the present study to achieve recommended dietary Se-intake levels, agronomic fortification with selenised fertilizers applied to highland barley could be a great solution. It is necessary to combine the influencing factors, and comprehensively consider the spatial variation of local soil properties, climatic and topographic conditions, and planting systems.
Breeding implications of nodulation performance and root structure under natural inoculation for soil fertility enhancement and sustainable cowpea production
Authors: Mekonnen Tesfaye Walle , Mekbib Firew , Amsalu Berhanu , Gedil Melaku , Labuschagne Maryke
Published: December 2022

Nitrogen deficiency is the most limiting abiotic stress factor affecting the grain yield of cowpea (Vigna unguiculata L.) in sub-Saharan Africa (SSA) countries. Breeding for high-yielding potential in association with high nitrogen fixation performance is the principal objective of cowpea breeding programs to improve both the productivity and production of this orphan crop in the region. Therefore, the present study was undertaken to determine the diversity of genotypes for nodulation capacity in two environments and to understand the root architecture and morphology of genotypes as well as grain yield and yield-related traits in 324 cowpea genotypes. The experiment was conducted in two different environments during the 2017 cropping season. The experiments were laid out in 18 × 18 simple lattice design. Grain yield exhibited highly significant and positive genotypic correlations with stem diameter, basal root length of 1st whorls, basal root branching density, taproot length and adventitious root length, demonstrating that selection of cowpea genotypes based on these traits could be effective to capitalize on grain yield under low nitrogen conditions. Days to flowering, days to maturity, stem diameter, 1st whorl angle, basal root length of 1st whorls, basal root branching density, taproot length, adventitious root diameter and adventitious root length had significant and positive genotypic correlations with days to maturity. The first ten principal components (PC) explained 65.13% of the total variation. Stem diameter, taproot width, and taproot length traits were important contributors to the variability in the first PC. The highest inter-cluster distance (D2) was recorded between clusters III and IV. However, clusters II and V recorded the minimum inter-cluster distance (78.96 units). The range of intra-cluster distance was 24.22–5,112.92 units, indicating that the high genetic distance displayed within and between clusters has to be exploited via crossing and selecting the most divergent parents for future cowpea improvement. Five clusters of cowpea genotypes were evident, and within the clusters, the genotypes had good nodulation potential with high grain yield traits, which could significantly contribute to SSA food and nutritional security. Moreover, it can contribute to resilience and improve crop production and sustainability under marginal environmental conditions.
Giant bleeding post-traumatic thoracic sarcoma management: A case report
Authors: Shabunin Alexey V , Lebedinsky Ivan N , Dolidze David D , Bagatelia Zurab A , Covantsev Serghei , Bocharnikov Dmitry S , Gogitidze Nodar N
Published: December 2022

The heterogeneity of thoracic wall tumors often represents challenging clinical entities for surgeons due to diagnostic and treatment complexities. The primary tumors, metastases, or direct invasion from intrathoracic structures comprise almost half of all cases on average that are proved to be malignant. Surgery treatment usually leaves large chest defects that require further extensive reconstruction and multimodal management including radiotherapy and chemotherapy. We report a rare case of a giant (30 cm) post-traumatic bleeding thoracic sarcoma treatment in a 70-year-old female. The use of our modified Verneuil technique to close the extensive postoperative skin defect optimized surgical wound management and provided good functional and aesthetic results. Four-year follow-up outcomes after surgical and adjuvant radiation therapy reported a high level of tumor control and showed no evidence of postoperative disease recurrence.
Coxiella burnetii and Co-Infections with Other Major Pathogens Causing Abortion in Small Ruminant Flocks in the Iberian Peninsula
Authors: Ramo María de los Angeles , Benito Alfredo A. , Quílez Joaquín , Monteagudo Luis V. , Baselga Cristina , Tejedor María Teresa
Published: December 2022

Coxiella burnetii is an intracellular bacterium causing human Q fever and reproductive disorders in domestic ruminants. We analyzed the occurrence of C. burnetii and co-infections with six other major pathogens causing abortion in sheep (1242 cases) and goat (371 cases) flocks from Spain and Portugal. After real-time PCR detection, co-infections were established by principal component and cluster analysis that grouped cases based on the joint presence/absence of several microorganisms. C. burnetii and Chlamydia abortus were the most common abortifacient agents with approximately 75% of cases from both hosts testing positive, followed by Toxoplasma gondii, Campylobacter sp., Salmonella enterica, border disease virus and Neospora caninum. C. burnetii was significantly more common than C. abortus in goat abortions (p < 0.001). Co-infections with at least two pathogens were found in more than 66% cases of ovine abortions and 36% cases of caprine abortions testing positive for C. burnetii, mostly including mixed infections with only C. abortus. These findings indicate that both pathogens are the most significant ones to be readily prevented by vaccination in this geographical area. Biosecurity and biocontainment measures are also steadfastly recommended to prevent both the economic losses and public health risks associated with most of these abortifacient agents.
Surfactin Containing Bacillus licheniformis-Fermented Products Alleviate Dextran Sulfate Sodium-Induced Colitis by Inhibiting Colonic Inflammation and the NLRP3 Inflammasome in Mice
Authors: Tsai Wei-Che , Wong Wei-Ting , Hsu Hsien-Ta , Cheng Yeong-Hsiang , Yu Yu-Hsiang , Chen Wei-Jung , Ho Chen-Lung , Hsu Hui-Chen , Hua Kuo-Feng
Published: December 2022

Inflammatory bowel disease (IBD) is a non-infectious disease characterized by chronic inflammation of the gastrointestinal tract. Currently, management of IBD is still a clinical challenge. The purpose of this study was to investigate the therapeutic potential of surfactin containing Bacillus licheniformis-fermented products (SBLF) and commercial surfactin (CS) on the treatment of dextran sulfate sodium (DSS)-induced colitis in a mouse model. We found that mice that received drinking water containing 3% DSS developed significant colitis symptoms, including increased disease activity index, body weight loss, shortening of the colon length, splenomegaly, colonic inflammation and colonic NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome activation. Notably, orally received SBLF, CS or clinical anti-inflammatory drug 5-aminosalicylic acid improved DSS-induced colitis symptoms in mice. These findings show that SBLF can improve IBD in mice by reducing colonic inflammation and inhibiting the NLRP3 inflammasome activation, suggesting that SBLF has the potential to be used as a nutraceutical in humans or a feed additive in economic and companion animals for preventing IBD.