bluuebunny/crossref_metadata_2025 huggingface dataset:
A produtividade da noção de cenografia para a abordagem dos gêneros do discurso em sala de aula
Authors: Khalil Lucas Martins Gama
Published: August 2022

Este artigo empreende uma reflexão acerca da abordagem dos gêneros do discurso em sala de aula, especificamente pelo viés de uma análise de discurso de base enunciativa. Objetiva-se discutir a questão a partir da noção de cenografia, proposta por Dominique Maingueneau (2008; 2011; 2015a; 2015b; 2020) como uma das três cenas de enunciação engendradas no funcionamento de um texto. A plasticidade das restrições de um gênero, em maior ou menor grau, é uma questão pouco focalizada, por exemplo, nos documentos nacionais regulamentadores do ensino, como a Base Nacional Comum Curricular. Nesse sentido, a discussão acerca da cenografia é um dos caminhos possíveis para suprir essa lacuna, na medida em que as variadas relações entre a cenografia e o quadro cênico (cena englobante e cena genérica) podem contribuir para a ruptura com certas leituras sobre o gênero discursivo que acabam o enquadrando como mero formato textual. Além de expor a teorização de cenografia, relacionando-a com alguns aspectos do ensino de língua, o artigo apresenta a análise de uma canção, a fim de ilustrar a variabilidade cenográfica que é característica de determinados gêneros.
Do gesto de formulação do gênero "anúncio publicitário" no livro didático de português do ensino médio
Authors: Silva José de Alcântara Ribeiro , De Deus Leite João
Published: August 2022

Neste trabalho, a partir da Análise de Discurso francesa, de orientação pecheutiana, tomamos o Livro Didático de Língua Portuguesa (LDLP) como objeto de análise e de problematização. Mais precisamente, o nosso interesse recaiu sobre o modo como os gêneros textuais anúncios publicitários foram formulados, no âmbito do LDLP, deixando entrever um “potencial de significação didática”. No entanto, há um trabalho discursivo em relação à materialidade de documentos oficiais sobre o ensino de Língua Portuguesa (LP). Esse conjunto de materialidade, que acaba por constituir as condições de produção dos LDLP, encerra uma “divisão social do trabalho da leitura,” conforme Pêcheux (2014). São basilares ainda, nesse processo, o jogo entre lugar discursivo de autor(es) e as tomadas de posição, como preconiza Grigoleto (2005). Para tanto, recorremos aos conceitos de constituição, de formulação e de circulação em Orlandi (2001), para verificar o gesto de formulação que a ele está subjacente e constitutivo. As análises mostram que o gesto de formulação do gênero textual questão está fundamentado em uma perspectiva de trabalho com a linguagem, com a língua e com a gramática, ainda, muito para se localizar e identificar informações. Não se radicaliza a perspectiva da dispersão de sentidos.
Por um ensino de literatura discursivo e decolonial
Authors: Madeira França Thyago
Published: August 2022

Ao pensarmos novas formas de politização do discurso literário com horizonte em uma escolarização crítica e social da literatura, nos aproximamos dos estudos dialógicos do Círculo de Bakhtin e da agenda da Linguística Aplicada crítica organizada por Moita Lopes (2013; 2006), os quais nos permitem lançarmos um olhar de ação e intervenção que seja capaz de identificar modos de decolonizar as estruturas hegemônicas de produção do conhecimento que aparelham o cânone escolarizado e as formas de produzir sentidos e subjetividades sobre o texto literário na escola. Dessa forma, a partir dessas inscrições teóricas e do reconhecimento do poder humanizador da literatura, objetivamos discutir as potencialidades de um ensino de literatura discursivo que seja viável ao contexto da escola pública. Para tanto, propomos que o ensino-aprendizagem se dê por meio de práticas de letramento literário, as quais defendem a formação efetiva do leitor na escola, bem como se apresentam como uma ferramenta produtiva. Mais do que revelar um método para a escolarização da literatura, nosso estudo busca incitar reflexões sobre contextos escolares em que os professores de literatura, agentes de letramento, possam provocar transformações nas malhas do poder colonial e fazer emergir uma produção mais democrática e (trans)formativa de conhecimentos sobre o discurso literário.
Results of a study of the quality of life in patients with highly active multiple sclerosis in Russia
Authors: Boiko A. N. , Bakhtiyarova K. Z. , Sherman M. A. , Goncharova Z. A. , Smagina I. V. , Khaibullin T. I. , Babicheva N. N. , Spirina N. N. , Yampolskaya-Gosteva I. A. , Sokolova I. A. , Greshnova I. V. , Nikitenkova V. E. , Lukashevich I. G. , Inzhinova A. V. , Malkova N. A. , Korobko D. S. , Boyko O. V. , Lozovskaya I. S.
Published: August 2022

Multiple sclerosis (MS) is a chronic autoimmune inflammatory demyelinating and neurodegenerative disease of the central nervous system. Now 2.8 million people in the world suffer from MS, since 2000 every 5 years there has been an increase in the number of MS patients by 10%. At the same time, the number of cases with highly active MS (HAMS) is increasing, i.e. cases of MS with two or more exacerbations without taking specific pathogenetic therapy or one exacerbation during taking MS disease-modifying therapies (DMTsMS), which is accompanied by the corresponding MRI data of the brain and spinal cord (presence of new or active lesions). Previously, there were no studies of quality of life (QoL) in this subgroup of patients in the world.Objective: to compare the QoL indicators of patients with HAMS with those of healthy people and patients with a typical course of relapsingremitting MS (RRMS).Patients and methods. The study included data on 518 patients from 14 regions of the Russian Federation for 2020–2021 years, in whom HAMS was confirmed during a second examination. We used the results of the analysis of clinical data from neurologists and data from questionnaires filled out by patients with HAMS. Two questionnaires were used in the work – the general (non-specific) Questionnaire for assessing the QoL, SF-36 (The MOS 36-item Short-Form Health Survey) and a special questionnaire for MS patients – MusiQoL (Multiple sclerosis Quality of Life).Results and discussion. Almost all indicators of QoL in HAMS were below the control. When compared with the typical course of RRMS, a more pronounced decrease in daily activity indicators, a significant impact of clinical symptoms on QoL, a negative attitude of patients towards the healthcare system, and a low overall health index were noted. Pearson correlation analysis revealed a stronger effect on QoL parameters of the frequency of exacerbations in HAMS than in RRMS.Conclusion. The data obtained in the study indicate the need for more active management of patients with HAMS using second-line DMTsMS.
Employee Performance of Life Insurance Companies:The Mediating Effect of Organizational Citizenship Behavior
Authors: Suhardi Suhardi , Soelistya Djoko , Setyaningrum Retno Purwani , Aisyah Nur , Nainggolan Nora Pitri
Published: August 2022

ThisÂ  studyÂ  aims to determine the impactÂ  ofÂ  employeeÂ  leadershipÂ  andÂ  teamÂ  member exchange through organizational citizenship behaviour on the employee performance ofÂ  foreignÂ  lifeÂ  insurances.Â  ThisÂ  researchÂ  usesÂ  theÂ  purposiveÂ  samplingÂ  methodÂ  for selection.Â  One hundredÂ  sixtyÂ  respondentsÂ  areÂ  participatingÂ  in theÂ  research used to test the model studied. The data is collected using a questionnaire and then analyzed using the SEM AMOS program. This study showed that servant leadership positively affectsÂ  organizationalÂ  citizenshipÂ  behavior,Â  teamÂ  memberÂ  exchange,Â  andÂ  employee performance. While team member exchange has a positive and significant impact on organizationalÂ  citizenshipÂ  behavior,Â  teamÂ  memberÂ  exchangeÂ  hasÂ  aÂ  negativeÂ  and significant effect on employee performance. Subsequently, organizational citizenship behavior positively and significantly impacts employee performance. The mediating effectÂ  indicatedÂ  thatÂ  teamÂ  memberÂ  exchangeÂ  andÂ  servantÂ  leadershipÂ  influence organizationalÂ  citizenshipÂ  behaviorÂ  andÂ  affectÂ  employeeÂ  performance.Â  TheÂ  study's resultsÂ  implyÂ  thatÂ  whenÂ  employeesÂ  performÂ  beyondÂ  theirÂ  jobsÂ  (organizational citizenship behavior roles) and engage in team member exchange, they have quality socialÂ  communicationÂ  withÂ  theÂ  workgroupÂ  members.Â  Additionally,Â  employeesÂ  who work under servant leadership can develop strong personal bonds. Employees with lowÂ  levelsÂ  ofÂ  autonomyÂ  inÂ  theirÂ  workÂ  canÂ  improveÂ  performanceÂ  ifÂ  mediatedÂ  by organizational citizenship behavior.
Compact thermo-mechanical models for the fast simulation of machine tools with nonlinear component behavior
Authors: Vettermann Julia , Steinert Alexander , Brecher Christian , Benner Peter , Saak Jens
Published: August 2022

In this contribution, advanced modeling of thermo-mechanical effects in machine tools with nonlinear machine components is investigated using the example of a feed axis. Strategies of model order reduction for this coupled thermo-mechanical model with nonlinear subsystem are presented. Numerical investigations of the performance of the resulting reduced-order model compared to the original one conclude this article.
Remarks on some variants of minimal point theorem and Ekeland variational principle with applications
Authors: Meghea Irina , Stamin Cristina Stefania
Published: August 2022

This paper presents some variants of minimal point theorem together with corresponding variants of Ekeland variational principle. In the second part of this article, there is a discussion on Ekeland variational principle and minimal point theorem relative to it in uniform spaces. The aim of these series of important results is to highlight relations between them, some improvements and specific applications.
Eigenvalue inclusion sets for linear response eigenvalue problems
Authors: He Jun , Liu Yanmin , Lv Wei
Published: August 2022

In this article, some inclusion sets for eigenvalues of a matrix in the linear response eigenvalue problem (LREP) are established. It is proved that the inclusion sets are tighter than the Geršgorin-type sets. A numerical experiment shows the effectiveness of our new results.
Liquid-phase hydrogenation of carbon tetrachloride catalyzed by three-dimensional graphene-supported palladium catalyst
Authors: Xie Zhuoyi , Guo Jianwei
Published: August 2022

In this article, a three-dimensional graphene (3DGN)-supported palladium metal catalyst was prepared by the impregnation method with noble metal palladium as the active component, aiming to synthesize a catalyst with high activity and high selectivity. Its catalytic performance in liquid-phase hydrochlorination of carbon tetrachloride (TTCM) was investigated. The influences of different Pd loadings, reduction temperatures, and reaction temperatures on the catalytic hydrogenation reaction were studied. The purpose is to explore the best operating conditions for the preparation of chloroform. The results show that the 3DGN-supported palladium catalyst exhibits excellent catalytic performance and high selectivity to chloroform in the hydrogenation of TTCM. When the Pd loading was 1.0 wt%, the reduction temperature was 773 K, and the hydrochlorination reaction temperature was 398 K, the conversion of TTCM was as high as 98.12%, and the selectivity of chloroform was 85.23%. The main by-product is dichloromethane. The selectivity of chloroform is affected by the increasing temperature but remains above 80%.
Automatic monitoring system of power equipment based on Internet of Things technology
Authors: Jiang Xianglong
Published: August 2022

With the rapid development of the social economy, the power industry is also developing rapidly, the electricity load is increasing, and the power grid structure is becoming increasingly complex, people put forward higher requirements for improving the reliability of power supply, the emergence of Internet of Things technology can meet people’s urgent needs in a timely manner. How to use the advanced Internet of Things technology to realize the automation of power equipment is an inevitable trend in the development of power systems, and it is also the technical driving force for the development of power equipment. Due to the problems of information islanding, simplification, and security in traditional power equipment monitoring systems, this paper studies the automation of power equipment monitoring systems based on the Internet of Things. The experimental results show that the introduction of the Internet of Things technology into the automatic monitoring system of power equipment increases the utilization rate of power equipment by 4.33%. In addition, the safety of power grid operation and the monitoring of power equipment are improved. Once the power equipment is abnormal, it will be detected in time to ensure the continuity of the power supply.
Toward laser-induced tuning of plasmonic response in high aspect ratio gold nanostructures
Authors: Pelaez-Fernandez Mario , Majérus Bruno , Funes-Hernando Daniel , Dufour Romain , Duvail Jean-Luc , Henrard Luc , Arenal Raul
Published: August 2022

High aspect-ratio gold nanostructures sustain Fabry–Perot-like surface plasmon responses from infrared to visible light energies. We show that some resonances can be tuned by means of laser irradiation, where low energy modes stay unperturbed. After laser irradiation, gold nanowires’ tips are transformed into nanoparticles of various sizes joint to gold nanowires, producing high aspect-ratio half-dumbbells and dumbbells structures. The plasmonic behaviour of both the nanowires and the newly created nanostructures has been characterised by in-depth monochromated electron energy loss spectroscopy (EELS) developed in a transmission electron microscope (TEM) and state-of-the-art discrete dipole approximation (DDA) calculations. All these analyses serve as experimental proof of the selective tuning (or robustness) of the plasmonic modes of the nanostructures in a specific spectral range, which is of critical interest regarding applications for sensing devices, nano-sources or nanophotonic waveguide, as well as optical remote control.
Senescent macrophages alter fibroblast fibrogenesis in response to SARS-CoV-2 infection
Authors: Pence Brandt , Zhang Yufeng , Antwi Ivy , Cory Theodore James
Published: August 2022

SARS-CoV-2 has, since its emergence in 2019, become a global pandemic. Disease outcomes are worsened in older patients who are infected. The causes for this is multifactorial, but one potential cause for this disparity is increased rates of cellular senescence in older individuals, particularly in immune cells. Cellular senescence, the accumulation of factors resulting in cell growth arrest and apoptosis resistance, increases as individuals age. In immune cells, senescence is associated with increased inflammation, and alterations in immune response. We utilized a co-culture system consisting of senescent or non-senescent macrophages directly cultured with fibroblasts, and infected with SARS-CoV-2. We assessed the expression of collagen and fibronectin, important molecules in the extracellular matrix, as well as a number of fibrogenic factors. We observed that infection with SARS-CoV-2 induced collagen production in co-cultures with senescent, but not non-senescent macrophages. Fibronectin expression was decreased in both co-culture conditions. While significant results were not observed, concentrations of other fibrogenic molecules were consistent with the collagen results. These data demonstrate that senescence in macrophages alters the production of fibrotic molecules from fibroblasts in a SARS-CoV-2 infection model. As collagen and fibronectin expression are generally directly correlated, this suggests that senescence dysregulates fibrogenesis in response to infection with SARS-CoV-2. There is a need to further investigate the mechanisms for these changes.
Reactivity of Unconventional Fly Ashes, SCMs, and Fillers: Effects of Sulfates, Carbonates, and Temperature
Authors: Wang Ying , Ramanathan Sivakumar , Burris Lisa , Hooton R. Douglas , Shearer Christopher R. , Suraneni Prannoy
Published: August 2022

Reactivity information for a range of unconventional fly ashes is unavailable in literature. The objective of this study is to quantify the reactivity of numerous unconventional fly ashes using the R3 test (ASTM C1897-20, Standard Test Methods for Measuring the Reactivity of Supplementary Cementitious Materials by Isothermal Calorimetry and Bound Water Measurements) and the modified R3 test and to determine how sulfates, carbonates, and temperature affect the measured reactivity. A small set of other supplementary cementitious materials and fillers was used to benchmark the fly ash results. Heat release, calcium hydroxide consumption, and bound water were measured for the different materials. For siliceous materials with relatively low calcium oxide (CaO) + aluminum oxide (Al2O3) contents, temperature had a dominant effect on the heat release. On the other hand, for materials with higher CaO + Al2O3 contents, the effects of sulfates and carbonates dominated the effect of temperature. The slow but sustained reactivity of Class F fly ashes highlighted the importance of kinetic corrections or extrapolations to the reactivity measured in the R3 test. However, when testing at 50°C, the heat release curves of all tested materials plateaued at the end of 10 days, indicating that kinetic corrections were not required. Correlations between reactivity and early- and later-age paste properties are discussed.
David Copperfield’s Moods
Authors: Simundich Joel
Published: August 2022

This article advocates reading for moods, moments in literary texts that draw attention to textual forms conditioning the experiential parameters of narrative. Drawing from Hans Ulrich Gumbrecht’s reception aesthetics, I demonstrate how the normative critical history of Charles Dickens’s 1850 novel David Copperfield is a product of the novel’s delimitation of its horizons of expectation and structuration of contingency. I then link these delimited horizons to the accepted austerity politics of academic labor today.
Lucretius Taken Lightly
Authors: Mathes Carmen Faye
Published: August 2022

Exploring literary forms through radical materialist lenses can animate notions of subjectivity beyond agential autonomy; however, the radical materialist joke is a form that disappoints this transgressive promise in the long eighteenth century by recurring to previously established logics of individuation and, specifically, patrilineal inheritance, in order to ensure humor that resonates. Jokes through and about Lucretius, which are also arch commentaries on women’s inadequate educations, from Aphra Behn, Anne Ingram, and Mary Robinson, reveal a rift between the joke as a potentially democratizing, radical material form and the joke as a boundary-setting exercise.
Atomic Individuals
Authors: Henderson Andrea
Published: August 2022

Victorian chemistry and Victorian political theory are both constructed around a foundational analytic unit: for the former, it is the atom, and for the latter, the individual. Because the latter construct was actually the more robust of the two, Victorian chemists used the resources of art and literature to lend individuality to atoms, while literary writers used chemistry to suggest that the category of the individual might be no more than a fiction of liberal theory.
Preparation of Magnesium Oxide Nanoparticles from a Sea Water Bittern as an Antibacterial Agent Against Escherichia coli
Authors: Ningrum Ananda Nurmalia Kusuma , Jumaeri Jumaeri
Published: August 2022

Bittern is a by-product of the manufacture of salt which has a high MgCl2 content. Bittern can produce Mg(OH)2 which is one of the important precursors of MgO. MgO compounds can be used as an antibacterial against E. coli that contaminates food. This research aims to synthesize MgO nanoparticles as well as antibacterial testing against E.coli. Synthesis was performed using the wet precipitation method with bittern reaction and technical NaOH with volume ratio 1: 1 which was then calcined at 5000C, 6000C, and 7000C. Characteristic tests using XRD, FT-IR, and SEM and antibacterial activity testing using disc diffusion method with concentrations of 10 mg/mL, 20 mg/mL, and 30 mg/mL. Inhibition is measured based on the size of the diameter of the bacterial growth inhibition area. Based on the results of the XRD test showed the result of pure MgO with a crystalline size of 6.3 nm; 7.2 nm; and 15.8 nm at each calcination temperature, the FT-IR test produced an absorption at a wave <450 cm-1 indicating the presence of MgO clusters and the SEM test produced a nano-structure that was almost round, dense as a cavity in the grains. The results of testing the antibacterial activity of MgO nanoparticles showed inhibitory activity with a diameter range between 5 mm - 8 mm which was interpreted in the medium category. The best inhibition value is 5000C calcination at a concentration of 30 mg/ml of 7.87 mm.
Characterization and Anti-Bacterial Activity Testing of the Nano Hydroxyapatite-Clove (Eugenia Caryophyllus) Against Streptococcus Mutans Bacteria
Authors: Akbar Achmad Fitriadi , Cahyaningrum Sari Edi
Published: August 2022

Hydroxyapatite is one of the materials as a source of calcium and phosphate in the tooth remineralization process. Several studies have shown that hydroxyapatite produces strong antibacterial activity against caries-causing bacteria. Dental caries are one of the tooth scrapings suffered by many people. Dental caries are caused by Streptococcus mutans. In addition to hydroxyapatite, essential oil derived from cloves also has a good antimicrobial function. The eugenol content in cloves can kill bacteria that are resistant to antibiotics. This study aims to determine the results of the physicochemical characterization and antibacterial test of Streptococcus mutans in the clove-hydroxyapatite nanoformulation. This study used a nano-hydroxyapatite-clove test material with various compositions of 0.5 mL, 1 mL, 2 mL, 3 mL, and 4 mL of clove oil, 1% hydroxyapatite, Tween, and propylene glycol. The results of FT-IR characterization showed OH, C-H, C-O, C=O, PO43-, and CO32- functional groups. In PSA testing, the smallest size is indicated by the variation in the composition of 1ml clove oil, which is 16.07nm. The measurement of the antibacterial activity test showed that the hydroxyapatite-clove nanoformulation was able to inhibit the growth of Streptococcus mutans bacteria, with normally distributed data (p=0,05) and produce a significant probability,000 (p<0,05).
Synthesis and Characterization of Hydroxyapatite-Nanosilver as Anti Bacteria that Cause Dental Caries
Authors: Lestari Nanda Revita Dwi , Cahyaningrum Sari Edi
Published: August 2022

The formation of dental caries is the result of the activity of Streptococcus mutans bacteria. Various attempts have been done to prevent dental caries. One of them is using oral preparations containing antibacterial compounds Hydroxyapatite-NanoSilver which is an active ingredient that can provide antimicrobial effects to prevent dental caries. This study aims to synthesize and characterize nanosilver hydroxyapatite as an antibacterial that causes dental caries. Physicochemical characterization and antibacterial test towards Streptococcus mutans bacteria with the active ingredient hydroxyapatite-nanosilver. In this study, hydroxyapatite-nanosilver materials with variations in nanosilver concentration of 4 ppm were used; 7 ppm; 10 ppm; 13 ppm; and 15 ppm. The results of FT-IR characterization showed the functional groups O-H, C=O, CO32-, and PO43-. The results of the PSA test showed that the hydroxyapatite-nanosilver formulation with a concentration of 10 ppm had the smallest nanoparticle size of 80.89 nm. Measurement of antibacterial activity test showed that the hydroxyapatite-nanosilver formulation was able to inhibit the growth of Streptococcus mutans bacteria. The highest diameter of resistance to the growth of mutant Streptococcus bacteria in hydroxyapatite-nanosilver formulations is 22.5 mm at a nanosilver concentration of 4 ppm.
Tofu Liquid Waste Treatment Process Using Anaerobic Baffled Reactor with Cow Stool and Lactobacillus casei Addition
Authors: Febriningrum Panca Nugrahini , Astawa I Nyoman Endra
Published: August 2022

Tofu liquid waste causes ecosystem damage due to its high organic matter content. Anaerobic baffled reactor (ABR) is a waste treatment in the absence of oxygen where there is a sedimentation process using activated sludge. This process converts organic material into methane gas, ammonia and hydrogen sulfide. This study aims to determine the effect of addition of cow feces and Lactobacillus casei bacteria on decreasing levels of COD, TSS, VSS, pH and gas pressure. The research process was carried out in two stages of processing tofu liquid waste, namely the batch and continuous stages. Batch and continuous processes use an ABR reactor which has four chambers. Parameters measured include, COD, TSS, VSS, pH and Gas Pressure. The results obtained by the best batch process were obtained without the addition of bacteria, the ratio of cow feces and activated sludge was 1:4, the COD removal was 81.63%, the TSS removal was 1,300 mg/L, the VSS removal was 1,200 mg/L and the pH value final 8.0 for 6 days. The best processing time in the continuous process is 6 hours, the COD removal is 78.12%, the TSS removal is 600 mg/L, the VSS removal is 500 mg/L and the final pH value is 6.5. It can be concluded that the more cow feces added, the faster and greater the removal of COD, TSS, VSS and pH values ​​tended to increase in the treatment of adding bacteria.
Isolation and Identification of Secondary Metabolic Compounds from Mangrove (Rhizophora mucronata) and their Bioactivity Against Escherichia coli and Staphylococcus aureus Bacteria
Authors: Ligina Anisa Sandhya , Sudarmin Sudarmin
Published: August 2022

Bacteria are often found as the cause of disease in the human body because they are pathogenic. One of the bacteria that cause infectious diseases is Escherichia coli and Staphylococcus aureus. Mangrove plants that are rich in secondary metabolites are used to obtain antibacterial substances that can play a role in inhibiting bacterial growth. The purpose of this study was to determine the presence of secondary metabolites of alkaloids in mangrove plants (Rhizophora mucronata) and to determine the antibacterial activity of alkaloid compounds in inhibiting the growth of Staphylococcus aureus and Escherichia coli bacteria. The research method was carried out by remaceration and isolation of alkaloid compounds, analysis of thin-layer chromatography (TLC) and column chromatography, and characterization tests using FT-IR and UV-Vis. The results of the analysis showed the presence of isoquinoline-derived alkaloids supported by FT-IR absorption at 3317 cm-1 indicating the N-H functional group which is a characteristic of alkaloids and the UV-Vis wavelength of 230 nm. These compounds can inhibit the growth of Staphylococcus aureus bacteria by 2 nm and Escherichia coli by 0 nm. The inhibition obtained against Escherichia coli bacteria was caused by the cell membrane layer of gram-negative bacteria consisting of 3 layers so that it was resistant to antibacterial and difficult to penetrate. Staphylococcus aureus only has a single layer, so it is more easily penetrated by antibacterials by causing lysis and inhibiting DNA intercalation.
Biosynthesis of ZnO Nanoparticles from Aqueous Extract of Moringa Oleifera L.: Its Application as Antibacterial and Photocatalyst
Authors: Rhamdiyah Fastabiqul Khairati , Maharani Dina Kartika
Published: August 2022

ZnO nanoparticles were successfully synthesized by the biosynthesis method using water extract of Moringa leaf (Moringa oleifera L.) as a reducing agent and stabilizer as well as a capping agent. This study aimed to characterize ZnO nanoparticles and their application as antibacterial and photocatalyst. Characterization was carried out using Fourier Transform Infrared (FT-IR) Spectroscopy and X-Ray Diffraction (XRD). The biosynthesis ZnO nanoparticles have a hexagonal wurtzite phase with an average crystal size of 16.97 nm and a crystallinity level of 78.49%. Antibacterial activity of ZnO nanoparticles with concentrations of 3%, 6%, 9% resulted in an average inhibition zone of bacterial growth in S. aureus was 19.6  0.16; 21.8  0.33; 24.3  0.14  and in E.coli it is 9.87  0.2; 11.3  0.04; 11.57  0.06. The greater the concentration of ZnO nanoparticles, the larger the diameter of the inhibition zone. The result of photodegradation of methylene blue is greatest with variations in the mass of ZnO nanoparticles and the concentration of methylene blue is 95% with a nanoparticle mass of 120 mg, methylene blue concentration of 10 ppm, and an irradiation time of 150 minutes.
A Review: Nanoparticles NiFe2O4 Synthesis and Its Application as Hyperthermia Agents in Biomedicine
Authors: Nurjanah Novi , Adzkia Qurratu Aini Alya , Rustana Riki , Carolline Selvi Citra , Agustine Shabrina Maulida , Nandiyanto Asep Bayu Dani
Published: August 2022

Nickel ferrite (NiFe2O4) is one of the spinel ferrite nanoparticles that is useful for scientific and technological, like biomedicine. This paper discusses the synthesis of NiFe2O4 nanoparticles by various methods. This paper aims to find out the most efficient method for the synthesis of NiFe2O4 nanoparticles which are used as hyperthermia agents in biomedicine. The method used is a literature study of an article with publications from 1956-2018 by discussing several methods of NiFe2O4 syntheses, such as sol-gel, hydrothermal, co-precipitation, and combustion. From these methods, it was found that co-precipitation is the most efficient method among the other methods because it produces a relatively small NiFe2O4 nanoparticle size, which is 28 nm, causing these small particles to tend to be superparamagnetic and is good to be used as hyperthermia agent in biomedicine. This study is expected to be used as a reference to determine the method for synthesizing NiFe2O4 nanoparticles.
Synthesis of Chitosan/Activated Carbon Composite Beads as an Adsorbent of Pb(II) and Cu(II) ions in Aqueous Solution: A Review
Authors: Wijayanti Indah Larasati Dwi , Mahatmanti F. Widhi
Published: August 2022

Water is the most important substance for the life of living things. The development of various industries causes water pollution by metal ions. Adsorption is a way to remove metal ions in water. The adsorbents commonly used for adsorption are chitosan and activated carbon. Chitosan has weaknesses such as being easily soluble in acid, low selectivity, and less strong mechanical strength. One way to improve the properties of chitosan is to modify it with activated carbon. In this study, a literature review was conducted on the manufacture of chitosan/activated carbon composite beads for Pb(II) and Cu(II) ions adsorbents. Reference sources articles obtained from the Google Scholar database were selected using exclusion and inclusion criteria. The results obtained from the literature review show that chitosan/activated carbon can be made by dissolving chitosan in a CH3COOH solution, adding with activated carbon to form a mixture and the mixture is formed into beads by dripping it into a NaOH solution. The adsorption process of chitosan/activated carbon is influenced by pH, contact time, and solution concentration. The reaction mechanism that occurs is thought to be through electrostatic bonds, the formation of complex compounds, and the pores of the adsorbent. Chitosan/activated carbon adsorbent is an adsorbent that can be regenerated and reused for adsorption 5 times.
OXIDATIVE STRESS AND REPRODUCTIVE FUNCTION: The impact of oxidative stress on reproduction: a focus on gametogenesis and fertilization
Authors: Aitken R John , Bromfield Elizabeth G , Gibb Zamira
Published: August 2022

In brief

Many aspects of the reproductive process are impacted by oxidative stress. This article summarizes the chemical nature of reactive oxygen species and their role in both the physiological regulation of reproductive processes and the pathophysiology of infertility.

This article lays out the fundamental principles of oxidative stress. It describes the nature of reactive oxygen species (ROS), the way in which these potentially toxic metabolites interact with cells and how they impact both cellular function and genetic integrity. The mechanisms by which ROS generation is enhanced to the point that the cells’ antioxidant defence mechanisms are overwhelmed are also reviewed taking examples from both the male and female reproductive system, with a focus on gametogenesis and fertilization. The important role of external factors in exacerbating oxidative stress and impairing reproductive competence is also examined in terms of their ability to disrupt the physiological redox regulation of reproductive processes. Developing diagnostic and therapeutic strategies to cope with oxidative stress within the reproductive system will depend on the development of a deeper understanding of the nature, source, magnitude, and location of such stress in order to fashion personalized treatments that meet a given patient’s clinical needs.
Comparison studies on sucrose metabolism and phenolic content during fruit growth and maturation in pear cultivars
Authors: Kaur A. , Sharma S. , Navprem S.
Published: August 2022

‘Patharnakh’ (Pyrus pyrifolia Burm.) (PN), a hard pear and ‘Punjab Beauty’ (Pyrus communis L. × Pyrus pyrifolia Burm.) (PB), a soft pear are dominant low-chill pear cultivars of subtropics of India. Present investigation reports the changes in sugar metabolism and related enzymatic activities in fruits of ‘PN’ and ‘PB’ cultivars harvested at different developmental stages from 45 to 150 days after fruit set. Total soluble sugars, fructose, and sucrose contents were higher in ‘PB’ as compared to ‘PN’ during fruit growth and maturation stages. Total phenols and flavanols increased initially and then showed a decreasing trend towards maturity. Sucrose synthase (SS) and sucrose phosphate synthase (SPS) activities strongly correlated to sucrose content in ‘PN’ but SPS was weakly related in ‘PB’ fruits. Acid and neutral invertases showed a negative correlation with sucrose content in ‘PN’, and a reverse trend in ‘PB’ cultivar was observed. It is concluded that SS and SPS are crucial for sucrose accumulation in ‘PN’, but invertase enzymes are also important for sucrose accumulation in ‘PB’ fruits.
Larvicidal activity of the crude methanolic extract from leaves of Clibadium surinamense against Aedes aegypti
Authors: Cruz Andrely de Jesus Soares da , Silva Wanessa Rendeiro da Silva e , Cruz Juliana dos Santos , Dantas Sampaio-Júnior Francisco , Monteiro Maria Vivina Barros , Hamoy Moises , Scofield Alessandra , Góes-Cavalcante Gustavo
Published: August 2022

ABSTRACT: The continuous use of synthetic insecticides for controlling the arboviral vector Aedes aegypti has led to the natural selection of mosquito populations resistant to different chemical groups. Thus, plant-derived compounds have emerged as a viable alternative for vectorcontrol. This study determined whether the crude methanolic extract (CME) from leaves of Clibadium surinamense has larvicidal activity against Ae. aegypti. Third- and fourth-instar Ae. Aegyptilarvae were kept in recipients containing 99 mL of water and 1mL of ethanol-diluted CMEat concentrations of 250, 500, 750, and 1000 ppm. The control group contained 99 mL of water and 1 mL of ethanol. Three trials were performed in triplicate for each group.After 24 hours of treatment, the LC50 and LC90 values were determined to be 283 and 430 ppm, respectively, according to one-way analysis of variance. In conclusion, we have demonstrated for the first time that the CME from leaves of C. surinamense show larvicidal activity against Ae. aegypti under laboratory conditions.
The midday sun reveals what the waters hide: Podocnemis unifilis Troschel, 1848 (Testudines, Podocnemididae), another exotic species in the Pantanal of Mato Grosso state
Authors: Silva Odair Diogo da , Silva Joselaine Souto Hall , Silva-Alves Vancleber Divino , Costa Thatiane Martins da , Fermiano Eder Correa , Muniz Claumir César , Ignácio Áurea Regina Alves , Carniello Maria Antonia , Vênere Paulo César , Santos Filho Manoel dos , Silva Dionei José da
Published: August 2022

Abstract The process of exotic species introduction is recognized as one of the greatest threats to the ecology and economy of the planet, due to changes in interactions in native biological communities. In this sense, reporting bioinvasions is the first step to understanding its introduction process and creating strategies to mitigate possible socio-environmental damages. Here we report the first records of Podocnemis unifilis introduced in the Northern Pantanal, Mato Grosso, Brazil. We obtained the species’ first records occasionally during 2014 and 2015. In the following years from 2016 to 2019, we carried out systematic observations through nautical incursions on the Paraguay River, between the Sepotuba River mouth and the Taiamã Ecological Station (TES). We also included third part records, when it was possible to prove the species identification and registration sites. Podocnemis unifilis adults, hatchling and nests were recorded at different points along the Paraguay River. Our results indicate that P. unifilis was introduced close to the urban nucleus of Cáceres about 30 years ago. Currently, it has an established population, recording nests and hatchling for years in a row. A particular one is its occurrence at the TES, an important natural fish nursery and refuge for the wetland fauna. Thus, continuous monitoring is suggested from P.unifilis, since the Pantanal’s environment with several different aquatic environments, offers favorable conditions for the species population increase in the Northern Pantanal.
HIBISCUS INCREASES FUNCTIONAL CAPACITY AND THE ANTI-OBESITY EFFECT IN TRAINED OBESE RATS
Authors: Oliveira Debora Bento Ortêncio de , Cunha Gisela Arsa , Giandoni Morenna Alana , Carvalho Paulo Cesar de Jesus , Bonfim Gisele Facholi , Leopoldo Ana Paula Lima , Leopoldo André Soares , Sugizaki Mário Mateus
Published: August 2022

ABSTRACT Introduction Hibiscus sabdariffa (Hs) has been widely used for weight loss and in the fight against obesity-associated comorbidities. Objective To evaluate the effects of Hs and physical training on the functional capacity of normal-weight and obese rats. Methods Wistar rats were distributed into eight experimental groups: control (C, n = 8) , Hibiscus Sabdariffa (Hs, n = 8), high-intensity interval training (IT, n = 8), high-intensity interval training + Hibiscus Sabdariffa (ITHs, n = 8), obese (O, n = 8), obese + continuous aerobic training (OAT, n = 8), obese + Hibiscus Sabdariffa (OHs, n = 8), , and obese + continuous aerobic training + Hibiscus Sabdariffa (OATHs, n = 8). Hibiscus Sabdariffa extract was administered for 60 days in a dose of 150 mg/kg of body weight. The maximum progressive effort test (MPET) was performed on a treadmill at the beginning and end of the study. The variables analyzed were maximum speed Vmáx time, and distance covered. Lactate was measured immediately after the MPET. Functional capacity was evaluated by the distance/adiposity index. The ANOVA with Bonferroni post hoc and Pearson’s correlation tests were used at a 5% significance level. Results After both types of training, moderate-intensity continuous and high-intensity interval performed on the treadmill, final body weight, weight gain, and the adiposity index decreased, and Vmax, time, and distance covered in the MPET increased, in addition to an improvement in functional capacity. Hs supplementation reduced the adiposity index in normal-weight and obese rats. Hs associated with aerobic training reduced final body weight and increased functional capacity. Conclusion Hs supplementation promoted a reduction in the adiposity index in normal-weight and obese rats and an increase in the functional capacity of trained obese rats. Level of Evidence III; Therapeutic Studies - Outcome Investigation. Case study – control.
Modelagem de quedas de pacientes adultos e as repercussões à Enfermagem como segunda vítima
Authors: Quadros Deise Vacario de , Magalhães Ana Maria Müller de , Wachs Priscila , Severo Isis Marques , Tavares Juliana Petri , Dal Pai Daiane
Published: August 2022

Resumo Objetivo: analisar as quedas de pacientes adultos hospitalizados e suas repercussões no trabalhador de Enfermagem como segunda vítima. Método: estudo exploratório, descritivo e qualitativo realizado em duas etapas - identificação das quedas com dano moderado ao grave e a modelagem das quedas com uso do software Functional Resonance Analysis Method e análise das repercussões no trabalhador como segunda vítima por meio de entrevistas semiestruturadas submetidas à Análise de Conteúdo, com 21 trabalhadores de Enfermagem. Resultados: identificadas 447 quedas de pacientes adultos, sendo 12 com dano moderado ao grave, ocorridas na ausência do acompanhante, no uso de medicamentos indutores do sono, hipotensores ou que alteram a força muscular. A modelagem identificou 22 funções relacionadas ao Procedimento Operacional Padrão, ao protocolo de prevenção de quedas e às ações pós-evento. Dessas, oito apresentaram variabilidade em sua execução. Na segunda etapa, emergiram as categorias “A complexidade dos cuidados para prevenir as quedas” e “Sentimentos da segunda vítima”. Conclusão: as quedas são fenômenos complexos e a prevenção exige envolvimento do paciente, família e equipe multiprofissional. Os profissionais envolvidos são segundas vítimas e experimentam sentimentos de culpa, medo, angústia e impotência. Este estudo pode contribuir com a multiprofissionalidade e na abordagem precoce às segundas vítimas.
Medical treatment in pregnant women with subclinical hypothyroidism: systematic review and meta-analysis
Authors: Abuhadba-Cayao Katia Andrea , Talavera Jesús E. , Vera-Ponce Víctor Juan , Cruz-Vargas Jhony A. De La
Published: August 2022

Abstract Objectives: to determine the effectiveness of medical therapy in reducing complications associated with subclinical hypothyroidism during pregnancy. Methods: in 2021, a systematic review of available cohort studies was carried out in three databases, with no publication date limit. Study selection and data extraction were performed in duplicate. Random-effects meta-analysis was performed, and odds ratios were calculated, with the corresponding 95% confidence intervals. Cohort risk of bias was assessed using the Newcastle-Ottawa Scale (NOS). The certainty of the evidence was assessed using the GRADE methodology. Results: five studies were included for qualitative and quantitative synthesis. A statistically significant relationship was found between medical treatment in pregnant women with subclinical hypothyroidism with respect to spontaneous abortion (p=0.03; OR=0.77; CI95%=0.61-0.97), and no statistically significant relationship was found for delivery preterm (p=0.46; OR=1.11; CI95%=0.85-1.44), nor for abrupt placentae (p=0.56; OR=1.60; CI95%=0.33-7.66). Three studies were at moderate risk of bias, and two were at low risk of bias. In all the results the certainty was very low. Conclusions: medical treatment of subclinical hypothyroidism during pregnancy can have a beneficial effect in reducing cases of spontaneous abortion.
Analysis of antepartum cardiotocography based on S/k proportions and probability in 20 minutes
Authors: Velásquez Javier Oswaldo Rodríguez , Páez Jaime Alberto Páez , Herrera Sandra Catalina Correa , Osorio Magda Liliana Villamizar , Bohórquez Signed Esperanza Prieto , Méndez Jairo Augusto Cortés , Herrera Fredys Alberto Simanca
Published: August 2022

Abstract Objectives: although mortality and perinatal asphyxia in newborns have been considerably reduced, there are still deficiencies in screening and diagnosis methods for intrapartum fetal well being that aim to detect its early alterations. Therefore, the purpose of this research was to apply a methodology based on probability and entropy and confirm its capacity to detect normal and abnormal fetal cardiac dynamics from 20-minute cardiotocographic tracings. Methods: 80 cardiotocographic tracings of pregnant women in the last trimester were collected, of which the minimum and maximum fetal heart rate were evaluated every 10 seconds, as well as its repetitions along with their probability and the diagnostic S/k ratio. Finally, the statistical analysis was carried out to establish the diagnostic capacity of the method concerning the clinical evaluation and interpretation of the cardiotocographic tracing, taken as the Gold Standard. Results: it was confirmed that S/k ratio values differentiated normal from abnormal fetal cardiac dynamics with sensitivity and specificity values of 100% and a Kappa coefficient of 1. Conclusion: the applicability of a diagnostic mathematical method of cardiotocography was confirmed, which suggests its implementation in the clinical context to detect alterations in fetal well-being in 20 minutes.
A poesia de terror em Paul Éluard, Julia Hartwig e Anne Sexton
Authors: Kempinska Olga Donata Guerizoli
Published: August 2022

Resumo: Ao indagar a complexa relação estética que se tece entre a poética do gótico e a poética do surrealismo, assegurada pelas experiências da crise do mito, do informe, e em consequência, do terror e do horror, neste artigo, proponho a leitura de alguns poemas que encenam essa difícil articulação. Paul Éluard, Julia Hartwig e Anne Sexton buscam, com efeito, os procedimentos aptos à encenação do doloroso desamparo subjetivo, que diz respeito, também, à questão dos limites do gênero. O regime da negatividade característico da poética gótica leva à recusa da busca por novos mitos e por novas imagens da criatividade feminina, típica do romantismo. Ao valorizar a representação do espaço, o gótico preparou o caminho da crítica, poética e feminista, dos discursos da psicanálise e da fenomenologia.
Violência de gênero e pandemia
Authors: Campos Carmen Hein de , Castilho Ela Wiecko Volkmer de , Machado Isadora Vier
Published: August 2022

Resumo: No artigo, apresenta-se experiências de três projetos de extensão realizados em universidades brasileiras, e debate em torno da “reinvenção” da atuação universitária durante a pandemia da COVID-19 em atividades de extensão relacionadas à violência contra mulheres. O direito de acesso à justiça pelas mulheres foi consideravelmente atingido pela dificuldade de acesso às tecnologias de informação e comunicação. Embora com as limitações das condições de trabalho remoto e adaptação às dinâmicas de atendimento virtual, os projetos se firmaram como importantes interlocutores, proporcionando às mulheres, respeitadas a autonomia e capacidade decisória, ambiente de acolhimento e escuta pautado na lógica feminista de intervenção e assessoramento.
UM ESTUDO EXPLORATÓRIO SOBRE TIPOS DE METÁFORAS E TAREFAS
Authors: SIMAN Josie Helen , SAMPAIO Thiago Oliveira da Motta , GOMES-JR Luiz Celso
Published: August 2022

RESUMO Como as pessoas interpretam as metáforas? O objetivo deste artigo é reconhecer a complexidade das metáforas além do escopo de qualquer teoria específica das metáforas. Em vez de ignorar evidências contraditórias, propomos destacar e analisar regularidades e irregularidades em nossos dados, usando insights da ciência de sistemas complexos para orientar nossas discussões. Neste estudo exploratório, os participantes foram convidados a substituir um veículo de metáfora por uma palavra com uma palavra de significado semelhante e a explicar a motivação analógica da metáfora. Havia três tipos de metáforas: primárias, complexas e atributivas. Este é o primeiro estudo a comparar esses três tipos de metáforas em duas tarefas diferentes. Os resultados mostram como as metáforas se agrupam de acordo com seu tipo, mas não uniformemente. Nesta análise quantitativa e qualitativa, também mostramos que múltiplas fontes de experiências estão disponíveis durante a interpretação da metáfora. Em conclusão, destacamos que nenhuma teoria atual pode acomodar e prever todos os tipos de comportamento metafórico que diferentes pessoas apresentam em diferentes contextos, mas entendemos alguns dos principais vieses e fatores que estão envolvidos na interpretação da metáfora.