bluuebunny/crossref_metadata_2025 huggingface dataset:
Aerodynamic Analysis of Rigid Wing Sail Based on CFD Simulation for the Design of High-Performance Unmanned Sailboats
Authors: Fang Shipeng , Tian Cunwei , Zhang Yuqi , Xu Changbin , Ding Tianci , Wang Huimin , Xia Tao
Published: August 2024

The utilization of unmanned sailboats as a burgeoning instrument for ocean exploration and monitoring is steadily rising. In this study, a dual sail configuration is put forth to augment the sailboats’ proficiency in its wind-catching ability and adapt to the harsh environment of the sea. This proposition is based on a thorough investigation of sail aerodynamics. The symmetric rigid wing sails NACA 0020 and NACA 0016 are selected for use as the mainsail and trailing wing sail, respectively, after considering the operational environment of unmanned sailboats. The wing sail structure is modeled using SolidWorks, and computational fluid dynamics (CFD) simulations are conducted using ANSYS Fluent 2022R1 software to evaluate the aerodynamic performance of the sails. Key aerodynamic parameters, including lift, drag, lift coefficient, drag coefficient, and thrust coefficient, are obtained under different angles of attack. Furthermore, the effects of mainsail aspect ratios, mainsail taper ratios, and the positional relationship between the mainsail and trailing sail on performance are analyzed to determine the optimal structure. The thrust provided by the sail to the boat is mainly generated by the decomposition of lift, and the lift coefficient is used to measure the efficiency of an object in generating lift in the air. The proposed sail structure demonstrates a 37.1% improvement in the peak lift coefficient compared to traditional flexible sails and exhibits strong propulsion capability, indicating its potential for widespread application in the marine field.
Deduplication-Aware Healthcare Data Distribution in IoMT
Authors: Altowaijri Saleh M.
Published: August 2024

As medical sensors undergo expeditious advancements, there is rising interest in the realm of healthcare applications within the Internet of Medical Things (IoMT) because of its broad applicability in monitoring the health of patients. IoMT proves beneficial in monitoring, disease diagnosis, and better treatment recommendations. This emerging technology aggregates real-time patient health data from sensors deployed on their bodies. This data collection mechanism consumes excessive power due to the transmission of data of similar types. It necessitates a deduplication mechanism, but this is complicated by the variable sizes of the data chunks, which may be either very small or larger in size. This reduces the likelihood of efficient chunking and, hence, deduplication. In this study, a deduplication-based data aggregation scheme was presented. It includes a Delimiter-Based Incremental Chunking Algorithm (DICA), which recognizes the breakpoint among two frames. The scheme includes static as well as variable-length windows. The proposed algorithm identifies a variable-length chunk using a terminator that optimizes the windows that are variable in size, with a threshold limit for the window size. To validate the scheme, a simulation was performed by utilizing NS-2.35 with the C language in the Ubuntu operating system. The TCL language was employed to set up networks, as well as for messaging purposes. The results demonstrate that the rise in the number of windows of variable size amounts to 62%, 66.7%, 68%, and 72.1% for DSW, RAM, CWCA, and DICA, respectively. The proposed scheme exhibits superior performance in terms of the probability of the false recognition of breakpoints, the static and dynamic sizes of chunks, the average sizes of chunks, the total attained chunks, and energy utilization.
On the Stability of the Linear Complexity of Some Generalized Cyclotomic Sequences of Order Two
Authors: Yan Chi , Tian Chengliang
Published: August 2024

Linear complexity is an important pseudo-random measure of the key stream sequence in a stream cipher system. The 1-error linear complexity is used to measure the stability of the linear complexity, which means the minimal linear complexity of the new sequence by changing one bit of the original key stream sequence. This paper contributes to calculating the exact values of the linear complexity and 1-error linear complexity of the binary key stream sequence with two prime periods defined by Ding–Helleseth generalized cyclotomy. We provide a novel method to solve such problems by employing the discrete Fourier transform and the M–S polynomial of the sequence. Our results show that, by choosing appropriate parameters p and q, the linear complexity and 1-error linear complexity can be no less than half period, which shows that the linear complexity of this sequence not only meets the requirements of cryptography but also has good stability.
RAAFNet: Reverse Attention Adaptive Fusion Network for Large-Scale Point Cloud Semantic Segmentation
Authors: Wang Kai , Zhang Huanhuan
Published: August 2024

Point cloud semantic segmentation is essential for comprehending and analyzing scenes. However, performing semantic segmentation on large-scale point clouds presents challenges, including demanding high memory requirements, a lack of structured data, and the absence of topological information. This paper presents a novel method based on the Reverse Attention Adaptive Fusion network (RAAFNet) for segmenting large-scale point clouds. RAAFNet consists of a reverse attention encoder–decoder module, an adaptive fusion module, and a local feature aggregation module. The reverse attention encoder–decoder module is applied to extract point cloud features at different scales. The adaptive fusion module enhances fine-grained representation within multi-resolution feature maps. Furthermore, a local aggregation classifier is introduced, which aggregates the features of neighboring points to the center point in order to leverage contextual information and enhance the classifier’s perceptual capability. Finally, the predicted labels are generated. Notably, our method excels at extracting point cloud features across different dimensions and produces highly accurate segmentation results. Experimental results on the Semantic3D dataset achieved an overall accuracy of 89.9% and a mIoU of 74.4%.
The Optimal Financing Decisions of Capital-Constrained Manufacturers under Different Power Structures
Authors: Xie Nan , Duan Zicong , He Haitao
Published: August 2024

This paper investigates the optimal financing decisions of capital-constrained manufacturers under different power structures. Using a Stackelberg game model, it analyzes the optimal equilibrium operational decisions of capital-constrained manufacturers at varying levels of internal capital. The study finds that, compared to a power structure dominated by eco-innovative enterprises, a power structure led by ordinary enterprises enhances the level of eco-innovation of innovative products and the overall profitability of the supply chain. When eco-innovative enterprises are well-capitalized, internal financing has lower costs but may lead to idle funds, while bank financing and mixed financing have higher costs but make full use of available capital. When eco-innovative enterprises are undercapitalized, mixed financing is the optimal choice. The research employs numerical simulations to analyze the impacts of consumer environmental awareness, innovation investment costs, and production costs on the level of eco-innovation in products, manufacturers’ profits, and the overall profitability of the supply chain, providing decision-making references for governments and enterprises.
Statistical Submanifolds Equipped with F-Statistical Connections
Authors: Peyghan Esmaeil , Nourmohammadifar Leila , Mihai Ion
Published: August 2024

This paper deals with statistical submanifolds and a family of statistical connections on them. The geometric structures such as the second fundamental form, curvatures tensor, mean curvature, statistical Ricci curvature and the relations among them on a statistical submanifold of a statistical manifold equipped with F-statistical connections are examined. The equations of Gauss and Codazzi of F-statistical connections are obtained. Such structures when the statistical submanifolds are conjugate symmetric are discussed. We present a inequality for statistical submanifolds in real space forms with respect to F-statistical connections. Also, we obtain a basic inequality involving statistical Ricci curvature and the squared F-mean curvature of a statistical submanifold of statistical manifolds.
A Cross-Sectional Study Comparing Oxidative Stress in Patients with Epilepsy Treated with Old and New Generation Antiseizure Medications
Authors: Martinc Boštjan , Grabnar Iztok , Milosheska Daniela , Lorber Bogdan , Vovk Tomaž
Published: August 2024

Background and Objectives: Oxidative stress resulting from a disturbance of the endogenous redox system is suspected in numerous diseases of the central nervous system, including epilepsy. In addition, antiseizure medications (ASMs), especially those of the old generation, may further increase oxidative stress. To evaluate the effects of ASM generation on oxidative stress, we conducted a cross-sectional study in patients with epilepsy treated with old, new, and polytherapy. Materials and Methods: The antioxidant activity of superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase, as well as the concentrations of malondialdehyde, protein carbonyl, nitrate, nitrite, and glutathione in reduced and oxidized forms, were measured in 49 patients with epilepsy and 14 healthy controls. In addition, the plasma concentrations of ASMs and metabolites of carbamazepine and valproic acid were measured in the patients. Results: Patients with epilepsy showed increased activities of superoxide dismutase and catalase (p < 0.001), concentrations of glutathione disulfide and markers of nitric oxide metabolism (p < 0.001), and decreased activities of glutathione peroxidase, glutathione reductase, glutathione, and nitrite concentrations (p ≤ 0.005) compared to healthy controls. A comparison of ASM generations revealed increased levels of superoxide dismutase and catalase (p ≤ 0.007) and decreased levels of glutathione peroxidase and glutathione reductase (p ≤ 0.01) in patients treated with old ASMs compared to those treated with new generation ASMs. In addition, an increase in protein carbonyl and nitric oxide metabolites (p ≤ 0.002) was observed in patients treated with old generation ASMs compared to those treated with new generation ASMs. Most oxidative stress parameters in patients receiving polytherapy with ASMs were intermediate between the results of patients treated with the old and new generations of ASMs. Conclusions: An increase in oxidative stress markers and modulation of antioxidant enzyme activities was observed in patients with epilepsy compared to controls. The results of our study showed significantly higher oxidative stress in patients treated with old ASMs compared to those treated with new generation ASMs.
An Exploratory Study on the Rapid Detection of Volatile Organic Compounds in Gardenia Fruit Using the Heracles NEO Ultra-Fast Gas Phase Electronic Nose
Authors: Cai Wenjing , Zhou Wei , Liu Jiayao , Wang Jing , Kuang Ding , Wang Jian , Long Qing , Huang Dan
Published: August 2024

Gardenia fruit is a popular functional food and raw material for natural pigments. It comes from a wide range of sources, and different products sharing the same name are very common. Volatile organic compounds (VOCs) are important factors that affect the flavor and quality of gardenia fruit. This study used the Heracles NEO ultra-fast gas phase electronic nose with advanced odor analysis performance and high sensitivity to analyze six batches of gardenia fruit from different sources. This study analyzed the VOCs to find a way to quickly identify gardenia fruit. The results show that this method can accurately distinguish the odor characteristics of various gardenia fruit samples. The VOCs in gardenia fruit are mainly organic acid esters, ketones, and aldehyde compounds. By combining principal component analysis (PCA) and discriminant factor analysis (DFA), this study found that the hexanal content varied the most in different gardenia fruit samples. The VOCs allowed for the fruit samples to be grouped into two main categories. One fruit sample was quite different from the fruits of other origins. The results provide theoretical support for feasibility of rapid identification and quality control of gardenia fruit and related products in the future.
A Wideband Millimeter-Wave Dual-Beam Dielectric Resonator Antenna with Substrate Integration Capability
Authors: Shi Jin , Xu Ranhao , Wu Bowen , Wang Lei , Jiang Ruirui
Published: August 2024

A wideband dual-beam dielectric resonator antenna (DRA) with substrate integration capability was proposed for millimeter-wave (mm-wave) applications. The four rows of air vias along the x-direction and two extended rectangular patches could shift the undesirable radiation mode upward and move the conical-beam radiation mode downward, respectively. Thus, the TE211 mode and the TE411 mode of the patch-loaded perforated rectangular substrate integrated dielectric resonator (SIDR) supporting the dual-beam radiation can be retained in the operating band, and their radiation can be improved by the air vias along the y-direction. The T-shaped line coupled dual-slot structure could excite the above two modes, and a dual-slot mode supporting dual-beam radiation could also work. Then, a wideband DRA with a stable dual-beam radiation angle can be achieved, and its impedance matching can be improved by two air slots on two sides. Compared with the state-of-the-art dual-beam antennas, the proposed antenna shows a wider bandwidth, a higher radiation efficiency, and the substrate integration capability of DRA, making it more suitable for mm-wave applications. For demonstration, a 1 × 4 array was designed with the 10 dB impedance matching bandwidth of 41.2% and the directions of the dual beams between ±30° and ±35°.
Fragmentation Characteristics of Bubbles in a Throttling Hole Pipe
Authors: Zhang Yufeng , Huang Zhijie , Sun Lixia
Published: August 2024

To enhance the performance of tubular microbubble generators, the Volume of Fluid (VOF) multiphase flow model in COMSOL Multiphysics was used to simulate the bubble fragmentation characteristics within a throttling hole microbubble generator. The effects of the inlet speed of the throttling hole pipe, the diameter of the throttling hole, and the length of the expansion section on bubble fragmentation performance were analyzed. The results indicated that an increase in the inlet speed of the throttling hole pipe gradually improved the bubble fragmentation performance. However, an increase in the throttling hole diameter significantly reduced the bubble fragmentation performance. Changes in the length of the expansion section had a minor impact on the bubble fragmentation performance. Experimental methods were used to verify the characteristics of bubble fragmentation, and it was found that the simulation and experimental results were consistent. This provides a theoretical basis and practical guidance for the design optimization of tubular microbubble generators.
Degradation Induced by Total Ionizing Dose and Hot Carrier Injection in SOI FinFET Devices
Authors: Yu Hao , Zhou Wei , Liu Hongxia , Wang Shulong , Chen Shupeng , Liu Chang
Published: August 2024

The working environment of electronic devices in the aerospace field is harsh. In order to ensure the reliable application of the SOI FinFET, the total ionizing dose (TID) and hot carrier injecting (HCI) reliability of an SOI FinFET were investigated in this study. First, the influence of TID on the device was simulated. The results show that TID causes the threshold voltage to decrease and the off-state current and subthreshold swing to increase. TID causes more damage to the device at high temperature and also reduces the saturation drain current of the device. HCI causes the device threshold voltage to increase and the saturation drain current to decrease. The HCI is more severe at high temperatures. Finally, the coupling effects of the two were simulated, and the results show that the two effects cancel each other out, and the degradation of various electrical characteristic parameters is different under different coupling modes.
Advanced Neural Functional Imaging in C. elegans Using Lab-on-a-Chip Technology
Authors: Kwon Youngeun , Kim Jihye , Son Ye Bin , Lee Sol Ah , Choi Shin Sik , Cho Yongmin
Published: August 2024

The ability to perceive and adapt to environmental changes is crucial for the survival of all organisms. Neural functional imaging, particularly in model organisms, such as Caenorhabditis elegans, provides valuable insights into how animals sense and process external cues through their nervous systems. Because of its fully mapped neural anatomy, transparent body, and genetic tractability, C. elegans serves as an ideal model for these studies. This review focuses on advanced methods for neural functional imaging in C. elegans, highlighting calcium imaging techniques, lab-on-a-chip technologies, and their applications in the study of various sensory modalities, including chemosensation, mechanosensation, thermosensation, photosensation, and magnetosensation. We discuss the benefits of these methods in terms of precision, reproducibility, and ability to study dynamic neural processes in real time, ultimately advancing our understanding of the fundamental principles of neural activity and connectivity.
High-Resolution Rotation-Measuring System for MEMS Ultrasonic Motors Using Tunneling Magnetoresistance Sensors
Authors: He Jiangbo , Feng Qiuyue , Chen Yu , Yang Tianyu , Li Xiaoshi , Zhou Wu
Published: August 2024

This study proposes a high-resolution rotation-measuring system for miniaturized MEMS ultrasonic motors using tunneling magnetoresistance (TMR) sensors for the first time. Initially, the architecture and principle of the rotation-measuring system are described in detail. Then, the finite element simulation is implemented to determine the miniaturized permanent magnet’s residual magnetization, dimensions, and TMR sensor position. Finally, the experiments are implemented to evaluate the performance. Using calibration based on a high-precision servo motor, it is found that the relationship between the output and rotational angle is highly linear and immune to the rotor’s out-of-plane movement. Meanwhile, the angle-detecting resolution is higher than 0.1°. After the calibration, the continuous rotation of the MEMS ultrasonic motor is tested. It is found that the angle testing result varies with a period close to 360°, which indicates that the rotation-measuring system has successfully detected the motor’s rotation.
Stratified Effects of Tillage and Crop Rotations on Soil Microbes in Carbon and Nitrogen Cycles at Different Soil Depths in Long-Term Corn, Soybean, and Wheat Cultivation
Authors: Shi Yichao , Gahagan Alison Claire , Morrison Malcolm J. , Gregorich Edward , Lapen David R. , Chen Wen
Published: August 2024

Understanding the soil bacterial communities involved in carbon (C) and nitrogen (N) cycling can inform beneficial tillage and crop rotation practices for sustainability and crop production. This study evaluated soil bacterial diversity, compositional structure, and functions associated with C-N cycling at two soil depths (0–15 cm and 15–30 cm) under long-term tillage (conventional tillage [CT] and no-till [NT]) and crop rotation (monocultures of corn, soybean, and wheat and corn–soybean–wheat rotation) systems. The soil microbial communities were characterized by metabarcoding the 16S rRNA gene V4–V5 regions using Illumina MiSeq. The results showed that long-term NT reduced the soil bacterial diversity at 15–30 cm compared to CT, while no significant differences were found at 0–15 cm. The bacterial communities differed significantly at the two soil depths under NT but not under CT. Notably, over 70% of the tillage-responding KEGG orthologs (KOs) associated with C fixation (primarily in the reductive citric acid cycle) were more abundant under NT than under CT at both depths. The tillage practices significantly affected bacteria involved in biological nitrogen (N2) fixation at the 0–15 cm soil depth, as well as bacteria involved in denitrification at both soil depths. The crop type and rotation regimes had limited effects on bacterial diversity and structure but significantly affected specific C-N-cycling genes. For instance, three KOs associated with the Calvin–Benson cycle for C fixation and four KOs related to various N-cycling processes were more abundant in the soil of wheat than in that of corn or soybean. These findings indicate that the long-term tillage practices had a greater influence than crop rotation on the soil bacterial communities, particularly in the C- and N-cycling processes. Integrated management practices that consider the combined effects of tillage, crop rotation, and crop types on soil bacterial functional groups are essential for sustainable agriculture.
Microbiota and Recurrent Pregnancy Loss (RPL); More than a Simple Connection
Authors: Garmendia Jenny Valentina , De Sanctis Claudia Valentina , Hajdúch Marián , De Sanctis Juan Bautista
Published: August 2024

Recurrent Pregnancy Loss (RPL) affects 1–2% of women, and its triggering factors are unclear. Several studies have shown that the vaginal, endometrial, and gut microbiota may play a role in RPL. A decrease in the quantity of Lactobacillus crispatus in local microbiota has been associated with an increase in local (vaginal and endometrial) inflammatory response and immune cell activation that leads to pregnancy loss. The inflammatory response may be triggered by gram-negative bacteria, lipopolysaccharides (LPS), viral infections, mycosis, or atypia (tumor growth). Bacterial structures and metabolites produced by microbiota could be involved in immune cell modulation and may be responsible for immune cell activation and molecular mimicry. Gut microbiota metabolic products may increase the amount of circulating pro-inflammatory lymphocytes, which, in turn, will migrate into vaginal or endometrial tissues. Local pro-inflammatory Th1 and Th17 subpopulations and a decrease in local Treg and tolerogenic NK cells are accountable for the increase in pregnancy loss. Local microbiota may modulate the local inflammatory response, increasing pregnancy success. Analyzing local and gut microbiota may be necessary to characterize some RPL patients. Although oral supplementation of probiotics has not been shown to modify vaginal or endometrial microbiota, the metabolites produced by it may benefit patients. Lactobacillus crispatus transplantation into the vagina may enhance the required immune tolerogenic response to achieve a normal pregnancy. The effect of hormone stimulation and progesterone to maintain early pregnancy on microbiota has not been adequately studied, and more research is needed in this area. Well-designed clinical trials are required to ascertain the benefit of microbiota modulation in RPL.
The Role of Postbiotics in Asthma Treatment
Authors: Węgrzyn Konstancja , Jasińska Agnieszka , Janeczek Kamil , Feleszko Wojciech
Published: August 2024

In recent years, there has been abundant research concerning human microbiome and its impact on the host’s health. Studies have shown that not only the commensal bacteria itself, but also postbiotics, understood as inanimate microorganisms, possibly with the presence of their components, may themselves have an effect on various elements of human physiology. In this review, we take a closer look at the specific ways in which postbiotics can alter immune response in allergic asthma, which is one of the most prevalent allergic diseases in today’s world and a serious subject of concern. Through altering patients’ immune response, not only to allergens but also to pathogens, postbiotics could have a significant role in lowering the number of asthma exacerbations. We suggest that more profound research should be undertaken in order to launch postbiotics into clinical standards of asthma treatment, given the greatly promising findings in terms of their immunomodulating potential.
Zirconium Phosphate-Pillared Zeolite MCM-36 for Green Production of γ-Valerolactone from Levulinic Acid via Catalytic Transfer Hydrogenation
Authors: Hou Pan , Su Haopeng , Jin Keyan , Li Qiang , Yan Wenfu
Published: August 2024

γ-valerolactone (GVL), derived from biomass, is a crucial platform compound for biofuel synthesis and various industrial applications. Current methods for synthesizing GVL involve expensive catalysts and high-pressure hydrogen, prompting the search for greener alternatives. This study focuses on a novel zirconium phosphate (ZrP)-pillared zeolite MCM-36 derivative catalyst for converting levulinic acid (LA) to GVL using alcohol as a hydrogen source. The incorporation of ZrP significantly contributes to mesoporosity and greatly enhances the acidity of the catalysts. Additionally, we employed 31P MAS NMR to comprehensively investigate the influence of phosphorus species on both the acidity and the catalytic conversion of LA to GVL. By adjusting the Zr-to-P ratios, we synthesized catalysts with enhanced acidity, achieving high conversion of LA and selectivity for GVL. The catalyst exhibited high recyclability, showing only minor deactivation over the course of five cycles. Furthermore, the catalyst was successfully applied to the one-pot conversion of furfural to GVL, showcasing its versatility in biomass conversion. This study highlights the potential of the MCM-ZrP1 catalyst for sustainable biomass conversion and offers insights for future research in renewable energy technologies.
Phytocompounds and Nanoformulations for Anticancer Therapy: A Review
Authors: Bozzuto Giuseppina , Calcabrini Annarica , Colone Marisa , Condello Maria , Dupuis Maria Luisa , Pellegrini Evelin , Stringaro Annarita
Published: August 2024

Cancer is a complex disease that affects millions of people and remains a major public health problem worldwide. Conventional cancer treatments, including surgery, chemotherapy, immunotherapy, and radiotherapy, have limited achievements and multiple drawbacks, among which are healthy tissue damage and multidrug-resistant phenotype onset. Increasing evidence shows that many plants’ natural products, as well as their bioactive compounds, have promising anticancer activity and exhibit minimal toxicity compared to conventional anticancer drugs. However, their widespread use in cancer therapy is severely restricted by limitations in terms of their water solubility, absorption, lack of stability, bioavailability, and selective targeting. The use of nanoformulations for plants’ natural product transportation and delivery could be helpful in overcoming these limitations, thus enhancing their therapeutic efficacy and providing the basis for improved anticancer treatment strategies. The present review is aimed at providing an update on some phytocompounds (curcumin, resveratrol, quercetin, and cannabinoids, among others) and their main nanoformulations showing antitumor activities, both in vitro and in vivo, against such different human cancer types as breast and colorectal cancer, lymphomas, malignant melanoma, glioblastoma multiforme, and osteosarcoma. The intracellular pathways underlying phytocompound anticancer activity and the main advantages of nanoformulation employment are also examined. Finally, this review critically analyzes the research gaps and limitations causing the limited success of phytocompounds’ and nanoformulations’ clinical translation.
Precisely Designed Morphology and Surface Chemical Structure of Fe-N-C Electrocatalysts for Enhanced Oxygen Reaction Reduction Activity
Authors: Chen Zirun , Xiong Yuang , Liu Yanling , Wang Zhanghongyuan , Zhang Binbin , Liang Xingtang , Chen Xia , Yin Yanzhen
Published: August 2024

Fe-N-C materials have been regarded as one of the potential candidates to replace traditional noble-metal-based electrocatalysts for the oxygen reduction reaction (ORR). It is believed that the structure of carbon support in Fe-N-C materials plays an essential role in highly efficient ORR. However, precisely designing the morphology and surface chemical structure of carbon support remains a challenge. Herein, we present a novel synthetic strategy for the preparation of porous carbon spheres (PCSs) with high specific surface area, well-defined pore structure, tunable morphology and controllable heteroatom doping. The synthesis involves Schiff-based polymerization utilizing octaaminophenyl polyhedral oligomeric silsesquioxane (POSS-NH2) and heteroatom-containing aldehydes, followed by pyrolysis and HF etching. The well-defined pore structure of PCS can provide the confinement field for ferroin and transform into Fe-N-C sites after carbonization. The tunable morphology of PCS can be easily achieved by changing the solvents. The surface chemical structure of PCS can be tailored by utilizing different heteroatom-containing aldehydes. After optimizing the structure of PCS, Fe-N-C loading on N,S-codoped porous carbon sphere (NSPCS-Fe) displays outstanding ORR activity in alkaline solution. This work paves a new path for fabrication of Fe-N-C materials with the desired morphology and well-designed surface chemical structure, demonstrating significant potential for energy-related applications.
Encoding CO2 Adsorption in Sodium Zirconate by Neutron Diffraction
Authors: Gammie Connor , Hesse Fabian , Kennedy Blair , Bos Jan-Willem G. , Sanna Aimaro
Published: August 2024

Recent research into sodium zirconate as a high-temperature CO2 sorbent has been extensive, but detailed knowledge of the material’s crystal structure during synthesis and carbon dioxide uptake remains limited. This study employs neutron diffraction (ND), thermogravimetric analysis (TGA), and X-ray diffraction (XRD) to explore these aspects. An improved synthesis method, involving the pre-drying and ball milling of raw materials, produced pure samples with average crystal sizes of 37–48 nm in the monoclinic phase. However, using a slower heating rate (1 °C/min) decreased the purity. Despite this, the 1 °C/min rate resulted in the highest CO2 uptake capacity (4.32 mmol CO2/g Na2ZrO3) and CO2 sorption rate (0.0017 mmol CO2/g) after 5 min at 700 °C. This was attributed to a larger presence of microstructure defects that facilitate Na diffusion from the core to the shell of the particles. An ND analysis showed that the conversion of Na2ZrO3 was complete under the studied conditions and that CO2 concentration significantly impacts the rate of CO2 absorption. The TGA results indicated that the reaction rate during CO2 sorption remained steady until full conversion due to the absorptive nature of the chemisorption process. During the sorbent reforming step, ND revealed the disappearance of Na2O and ZrO2 as the zirconate phase reformed. However, trace amounts of Na2CO3 and ZrO2 remained after the cycles.
Improved Anti-Oxidant and Anti-Bacterial Capacities of Skim Milk Fermented by Lactobacillus plantarum
Authors: Wang Ying , Zhao Bingtian , Ding Yun , Liu Nan , Yang Cheng , Sun Yajuan
Published: August 2024

Milk, on account of its abundant protein content, is recognized as a vital source of bioactive substances. In this study, the bioactive ingredients in milk were obtained by a combination of protease hydrolysis and fermentation with Lactobacillus plantarum. The compositions of protease hydrolysate (PM) and fermentation supernatant (FM) were determined, and their anti-oxidant and anti-bacterial activities were evaluated. Using LC-MS/MS, the molecular weights and sequences of the peptides were characterized, among which a total of 25 bioactive peptides were identified. The DPPH radical scavenging results demonstrated that FM exhibited an enhanced anti-oxidant capacity compared to PM. The bacterial survival rate results revealed that FM had a remarkable anti-bacterial ability compared to PM. Additionally, the anti-bacterial component and potential anti-bacterial mechanisms were determined. The results of cytoplasmic membrane depolarization, cell membrane permeability, and morphological observation indicated that FM could interact with bacterial membranes to achieve its anti-bacterial effect. These findings suggested that FM, as a bioactive substance of natural origin, holds potential applications in the functional food, pharmaceutical, and cosmetic industries.
New Insights Regarding the Use of Relevant Synthetic Compounds in Dentistry
Authors: Dumitrel Stefania-Irina , Matichescu Anamaria , Dinu Stefania , Buzatu Roxana , Popovici Ramona , Dinu Dorin , Bratu Dana
Published: August 2024

Worldwide, synthetic compounds are used for both in-office and at-home dental care. They are a valuable resource for both prophylactic and curative treatments for various dental problems, such as tooth decay, periodontal diseases, and many more. They are typically preferred due to their broad range of actions and ability to produce targeted, rapid, and long-lasting effects. Using a 0.12% chlorhexidine mouthwash is capable of reducing the plaque index from 47.69% to 2.37% and the bleeding index from 32.93% to 6.28% after just 2 weeks. Mouthwash with 0.1% OCT is also highly effective, as it significantly lowered the median plaque index and salivary bacterial counts in 152 patients in 5 days compared to a control group (p < 0.0001), while also reducing the gingival index (p < 0.001). When povidone-iodine was used as an irrigant during the surgical removal of mandibular third molars in 105 patients, it resulted in notably lower pain scores after 2 days compared to a control group (4.57 ± 0.60 vs. 5.71 ± 0.45). Sodium hypochlorite is excellent for root canal disinfection, as irrigating with 1% NaOCl completely eliminated the bacteria from canals in 65% patients. A 0.05% CPC mouthwash proved effective for perioperative patient care, significantly decreasing gingival bleeding (p < 0.001) and suppressing Streptococcus levels even one week post-surgery. Lastly, a 6% H2O2 paint-on varnish and 6% H2O2 tray formulations successfully bleached the teeth of 40 patients, maintaining a noticeably whiter appearance up to the 6-month follow-up, with significant color differences from the baseline (p < 0.005). Synthetic compounds have a large research base, which also provides a greater awareness of their mechanism of action and potential adverse effects. For a better understanding of how they work, several methods and assays are performed. These are protocolary techniques through which a compound’s efficacy and toxicity are established.
Cultivated Winter-Type Lunaria annua L. Seed: Deciphering the Glucosinolate Profile Integrating HPLC, LC-MS and GC-MS Analyses, and Determination of Fatty Acid Composition
Authors: De Nicola Gina Rosalinda , Montaut Sabine , Leclair Kayla , Garrioux Joëlle , Guillot Xavier , Rollin Patrick
Published: August 2024

Lunaria annua L. (Brassicaceae) is an ornamental plant newly identified in Europe as a promising industrial oilseed crop for its valuable very-long-chain monounsaturated fatty acids (MUFAs), especially erucic acid (EA) and nervonic acid (NA). L. annua seeds were obtained from annual winter-type plants selected and cultivated in Northern France. Using a systematic multiple-method approach, we set out to determine the profile and content of glucosinolates (GSLs), which are the relevant chemical tag of Brassicaceae. Intact GSLs were analyzed through a well-established LC-MS method. Identification and quantification were performed by HPLC-PDA of desulfo-GSLs (dGLs) according to the official EU ISO method. Moreover, GSL structures were confirmed by GC-MS analysis of the related isothiocyanates (ITCs). Seven GSLs were identified, directly or indirectly, as follows: 1-methylethyl GSL, (1S)-1-methylpropyl GSL, (Rs)-5-(methylsulfinyl)pentyl GSL, (Rs)-6-(methylsulfinyl)hexyl GSL, (2S)-2-hydroxy-4-pentenyl GSL, 2-phenylethyl GSL, and 1-methoxyindol-3-ylmethyl GSL. In other respects, the FA composition of the seed oil was determined. Results revealed cultivated L. annua seed to be a source of NA-rich oil, and presscake as a valuable coproduct. This presscake is indeed rich in GSLs (4.3% w/w), precursors of promising bioactive molecules for agricultural and nutraceutical applications.
Ionic Liquid-Catalyzed CO2 Conversion for Valuable Chemicals
Authors: Wang Peng , Wang Rui
Published: August 2024

CO2 is not only the main gas that causes the greenhouse effect but also a resource with abundant reserves, low price, and low toxicity. It is expected to become an important “carbon source” to replace oil and natural gas in the future. The efficient and clean resource utilization of CO2 has shown important scientific and economic value. Making full use of abundant CO2 resources is in line with the development direction of green chemistry and has attracted the attention of scientists. Environmentally friendly ionic liquids show unique advantages in the capture and conversion of CO2 due to their non-volatilization, designable structure, and good solubility, and show broad application prospects. The purpose of this paper is to discuss the research on the use of an ionic liquid as a catalyst to promote the synthesis of various value-added chemicals in CO2, hoping to make full use of CO2 resources while avoiding the defects of the traditional synthesis route, such as the use of highly toxic raw materials, complicated operation, or harsh reaction conditions. The purpose of this paper is to provide reference for the application and development of ionic liquids in CO2 capture and conversion.
Effects of Fermentation with Kombucha Symbiotic Culture of Bacteria and Yeasts on Antioxidant Activities, Bioactive Compounds and Sensory Indicators of Rhodiola rosea and Salvia miltiorrhiza Beverages
Authors: Cheng Jin , Zhou Dan-Dan , Xiong Ruo-Gu , Wu Si-Xia , Huang Si-Yu , Saimaiti Adila , Xu Xiao-Yu , Tang Guo-Yi , Li Hua-Bin , Li Sha
Published: August 2024

Kombucha is a well-known fermented beverage traditionally made from black tea infusion. Recent studies have focused on finding alternative materials to create novel kombucha beverages with various health benefits. In this study, we prepared and evaluated two novel kombucha beverages using Rhodiola rosea and Salvia miltiorrhiza as materials. The effects of fermentation with the residue of these plants on the kombucha were also investigated. The antioxidant activities, total phenolic contents, and concentrations of the bioactive compounds of the kombucha beverages were determined by the Trolox equivalent antioxidant capacity test, ferric-reducing antioxidant power test, Folin–Ciocalteu method, and high-performance liquid chromatography, respectively. The results revealed that the kombucha beverages made with Rhodiola rosea and Salvia miltiorrhiza had strong antioxidant capacities and abundant phenolic contents. Additionally, the kombucha fermented with Rhodiola rosea residue had higher FRAP, TEAC and TPC values than that fermented without residue. On the other hand, the Salvia miltiorrhiza kombucha fermented with residue had similar FRAP and TEAC values but lower TPC values compared to that fermented without residue. The correlation analysis showed that gallic acid, salidroside, and tyrosol were responsible for the antioxidant abilities and total phenolic contents of the Rhodiola rosea kombucha, and salvianolic acid A and salvianolic acid B contributed to the antioxidant abilities of the Salvia miltiorrhiza kombucha. Furthermore, the kombucha fermented with Rhodiola rosea residue had the highest sensory scores among the kombucha beverages studied. These findings suggest that Rhodiola rosea and Salvia miltiorrhiza are suitable for making novel kombucha beverages with strong antioxidant abilities and abundant phenolic contents, which can be used in preventing and managing oxidative stress-related diseases.
A New Wound-Healing Tool Based on Glycyrrhiza glabra Extract-Loaded Ufasomes on Spanish Broom Dressings
Authors: Rossello Simone , Mandrone Manuela , Cerchiara Teresa , Chiocchio Ilaria , Rossi Martina , Chinnici Fabio , Sallustio Valentina , Aponte Maria , Blaiotta Giuseppe , Luppi Barbara , Abruzzo Angela , Bigucci Federica , Cappadone Concettina
Published: August 2024

The development of innovative products for restoring skin integrity and promoting wound healing is still a challenge. The aim of this work was to evaluate an innovative Spanish broom wound dressing impregnated with Glycyrrhiza glabra extract-loaded ufasomes to improve wound healing. Ufasomes were characterized in terms of size, polydispersity index, entrapment efficiency, zeta potential, and stability. In addition, in vitro release studies and biocompatibility, biosafety, and scratch tests on WS1 fibroblasts were performed. The loaded ufasomes showed a nanometric size (<250 nm), good size distribution (lower than 0.3), and appropriate encapsulation efficiency (~67%). Moreover, the lipid vesicles showed good stability during the storage period and allowed for a slow release of glycyrrhizin, the main bioactive compound of the extract. Biological studies revealed that loaded vesicles are not cytotoxic, are hemocompatible, and lead to the complete closure of the scratch after about 33 h. To conclude, the results suggest that the developed dressings can be efficiently used to promote the healing process.
Synthesis, Structural Properties and Biological Activities of Novel Hydrazones of 2-, 3-, 4-Iodobenzoic Acid
Authors: Czyżewska Izabela , Mazur Liliana , Biernasiuk Anna , Hordyjewska Anna , Popiołek Łukasz
Published: August 2024

Nowadays, searching for novel antimicrobial agents is crucial due to the increasing number of resistant bacterial strains. Moreover, cancer therapy is a major challenge for modern medicine. Currently used cytostatics have a large number of side effects and insufficient therapeutic effects. Due to the above-mentioned facts, we undertook research to synthesize novel compounds from the acylhydrazone group aimed at obtaining potential antimicrobial and anticancer agents. As a starting material, we employed hydrazides of 2-, 3- or 4-iodobenzoic acid, which gave three series of acylhydrazones in the condensation reaction with various aldehydes. The chemical structure of all obtained compounds was confirmed by IR, 1H NMR, and 13C NMR. The structure of selected compounds was determined by single-crystal X-ray diffraction analysis. Additionally, all samples were characterized using powder X-ray diffraction. The other issue in this research was to examine the possibility of the solvent-free synthesis of compounds using mechanochemical methods. The biological screening results revealed that some of the newly synthesized compounds indicated a beneficial antimicrobial effect even against MRSA—the methicillin-resistant Staphylococcus aureus ATCC 43300 strain. In many cases, the antibacterial activity of synthesized acylhydrazones was equal to or better than that of commercially available antibacterial agents that were used as reference substances in this research. Significantly, the tested compounds do not show toxicity to normal cell lines either.
Hydrogen Production from Ammonia Decomposition: A Mini-Review of Metal Oxide-Based Catalysts
Authors: Xi Senliang , Wu Wenying , Yao Wenhao , Han Ruodan , He Sha , Wang Wenju , Zhang Teng , Yu Liang
Published: August 2024

Efficient hydrogen storage and transportation are crucial for the sustainable development of human society. Ammonia, with a hydrogen storage density of up to 17.6 wt%, is considered an ideal energy carrier for large-scale hydrogen storage and has great potential for development and application in the “hydrogen economy”. However, achieving ammonia decomposition to hydrogen under mild conditions is challenging, and therefore, the development of suitable catalysts is essential. Metal oxide-based catalysts are commonly used in the industry. This paper presents a comprehensive review of single and composite metal oxide catalysts for ammonia decomposition catalysis. The focus is on analyzing the conformational relationships and interactions between metal oxide carriers and active metal sites. The aim is to develop new and efficient metal oxide-based catalysts for large-scale green ammonia decomposition.
Slowing Down the “Magic Bullet”: Encapsulation of Imatinib in Fe-MOF for Cardiotoxicity Reduction and Improvement in Anticancer Activity
Authors: Strzempek Weronika , Menaszek Elżbieta , Papież Monika , Gil Barbara
Published: August 2024

Imatinib, a small molecule kinase inhibitor, is used as a cancer growth blocker. However, one of its most serious side effects is congestive cardiac failure. Reducing drug toxicity may be achieved through the use of drug delivery systems. Biocompatible metal-organic framework (MOF) materials, namely FeMIL-100 and FeMIL-101-NH2, were employed as potential imatinib carriers. They efficiently delivered the drug as an anticancer agent while minimizing cardiotoxicity. Notably, the release of imatinib from FeMIL-100 was rapid in acidic conditions and slower in pH-neutral environments, allowing targeted delivery to cancer cells. The carrier’s pH-dependent stability governed the drug release mechanism. Two release models—Korsmeyer–Peppas and Weibull—were fitted to the experimental data and discussed in terms of drug release from a rigid microporous matrix. Cytotoxicity tests were conducted on two cell lines: HL60 (a model cell line for acute myeloid leukemia) and H9c2 (a cell line for cardiomyocytes). Overall, the metal-organic framework (MOF) carriers mitigated imatinib’s adverse effects without compromising its effectiveness.
Theoretical Investigations on Free Energy of Binding Cilostazol with Different Cyclodextrins as Complex for Selective PDE3 Inhibition
Authors: Hoelm Marta , Chowdhury Nilkanta , Biswas Sima , Bagchi Angshuman , Małecka Magdalena
Published: August 2024

Cilostazol is a phosphodiesterase III inhibitor characterized by poor solubility. This limitation can be overcome by using a drug carrier capable of delivering the drug to the target site. Cyclodextrins are essential as drug carriers because of their outstanding complexation abilities and their capacity to improve drug bioavailability. This study comprises two stages: The first involves verifying different cyclodextrins and their complexation abilities towards cilostazol. This was accomplished using molecular docking simulations (MDS) and density functional theory (DFT). Both techniques indicate that the largest Sulfobutyl Ether-β-Cyclodextrin forms the most stable complex with cilostazol. Additionally, other important parameters of the complex are described, including binding sites, dominant interactions, and thermodynamic parameters such as complexation enthalpy, Gibbs free energy, and Gibbs free energy of solvation. The second stage involves a binding study between cilostazol and Phosphodiesterse3 (PDE3). This study was conducted using molecular docking simulations, and the most important energetic parameters are detailed. This is the first such report, and we believe that the results of our predictions will pave the way for future drug development efforts using cyclodextrin–cilostazol complexes as potential therapeutics.