bluuebunny/crossref_metadata_2025 huggingface dataset:
Juozas Darnijonaitis und die litauische Schule
Authors: Verikaitė Vitolda
Published: December 2023

Wir machen mit Leben und Ttigkeit des Lehrers bekannt, der die Grundlagen des Bildungs­wesens der litauischen Grundschule entwickelt hat.
Olympiads in informatics: problems from the mathematical approach
Authors: Dagienė Valentina
Published: December 2023

The paper deals with the problems delivered at the National Olympiads in Informatics from the mathemat­ical approach. Over 300 of problems have been analyzed, they were classified, and statistical analysis of each group was submitted. It was found that in Lithuanian Olympiads in Informatics the problems bound with graphs dominates. These problems usually are solved implementing different kind of methods.
Activities of the Mathematical Society in 2002–2004
Authors: Kubilius Jonas
Published: December 2023

The article gives a survey of activities of the Mathematical Society during last three years. Some prob­lems of the mathematical life in Lithuania are rised.
The distributions of sums of the prime indicators with respect to distinct frequencies
Authors: Šiaulys Jonas
Published: December 2023

A characterization of a set of strongly additive functions fx which has the same limit law with respect to ordinary and logarithmic frequencies is obtained. Strongly additive functions which take zero or unit for each prime p are considered.
Factoring with Pell conics
Authors: Šleževičienė Rasa
Published: December 2023

In the paper the Pell conics method for factoring integers, based on observations of Lemmer­meyer [2, 3], is presented explicitly. Moreover, a similar algorithm for factoring polynomials over finite fields is given.
Представление решений сильно вырождающегося матричного дифференциального уравнения в частных производных интегралом Лапласа
Authors: Jurgaitis Donatas
Published: December 2023

There is not abstract.
О расположении корней некоторых специальных полиномов
Authors: Kirjackis Eduardas , Kirjackis Dimitrijus
Published: December 2023

There is not abstract.
Business rules modeling using OCL
Authors: Sosunovas Sergejus , Vasilecas Olegas
Published: December 2023

Business rules are important components of every business system. Therefore creating information systems aimed to support business it is important to specify business rules unambiguously. Formal specification languages have different power specifying business rules of different types. This work argues that formal language OCL powerful enough to specify business rules of main types.
The efficiency of enabling to study mathematics module for first year students
Authors: Dabrišienė Vilija , Šileikienė Regina Dalytė
Published: December 2023

The practice and research shows, that usual student, who is taking studies in KTU can't study higher mathematics successfully, because he hasn't necessary knowledge and skills. It is necessary to create study­ing environments, where the student can prepare for studies, if he wishes. One of these ways is the enabling to study mathematics module, which was introduced in KTU. The efficiency of this module was the object of our research. The results of research are presented in this article.
About the provability of the Kotzig's hypothesis
Authors: Maliaukienė Livija
Published: December 2023

In the paper Kotzig's hypothesis are investigated and turning its into theorem from the point of views of history are presented.
Analysis of quasi-lattice distributions of statistics from finite population
Authors: Turkuvienė Jurgita , Bikelis Algimantas
Published: December 2023

Edgeworth expansions are used for approximation of quantiles, estimation of parameters, construction of confidence intervals and testing hypothesis. Paper shows how to construct  ` `  long'' Edgewort asymptotic expansions.
Multiphase fluid flow solver and its application to multidimentional problems
Authors: Jakušev Aleksandr , Starikovičius Vadimas
Published: December 2023

Modelling of fluid flow in porous media plays an important part in many applications. The authors have created extensible software package (the solver) for this task, using object-oriented approach. After a short introduction to the problems aimed by this solver, the solver is described, followed by the results of benchmarking and numerical solution of Buckley–Leverett 2-D problem.
The properties of nonuniformity analysis of high dimensional data
Authors: Šaltenis Vydūnas
Published: December 2023

A novel approach to outlier detection and clustering on the ground of the distribution of distances between multidimensional points is presented. The basic idea is to eval uate the outlier factor for each data point.A comparison with some popular outlier detection and clustering methods shows the superiority of our approach.
Simulation of nuclear reactor control and protection system
Authors: Bubelis Evaldas , Listopadskis Narimantas , Pabarčius Raimondas
Published: December 2023

Ignalina NPP RBMK-1500 reactor control and protection system (RCPS) logic, which was implemented in code QUABOX/CUBBOX-HYCA, is described in the paper. Analysis of numerical simulation results shows, that logic of RBMK-1500 RPSS is adequate to logic as described in technical literature. Simulation results obtained by code QUABOX/CUBBOX-HYCA were compared with simulation results obtained us­ing STEPAN code. The conclusion was made that RCPS operation sequences and response are analogical. The complement the code QUABOX/CUBBOX-HYCA with full realistic RCPS logic allows to simulate the transient processes and accidents, which have place in the reactor core of Ignalina nuclear power plant.
The planning model of dairy farm
Authors: Skarulskienė Irma
Published: December 2023

The optimal plan creation for each year of three years period and manufacture prognostication mathemati­cal model, which evaluates the relations between plant growing and stockbreeding, is presented. Described model allows counting of the plant growing and stockbreeding manufacturing volumes, the farm direct expenses, and marketable production. The direct programming method is used for finding of maximized benefit.
Fundamental J. Hajek lema for samples from finite population of vectors
Authors: Bikelis Algimantas , Turkuvienė Jurgita
Published: December 2023

Paper deals with J. Hajek's lema for samples from finite population of vectors.
Synthesis and characterisation of lanthanide phosphates for biomedical applications / Darius Budrevičius
Authors:   , Budrevičius Darius
Published: December 2023

Lantanoidų fosfatų sintezė ir apibūdinimas biomedicinos tikslais
Development of the Reliability Assurance Program in a Brazilian nuclear power plant subsidized by a Reliability, Availability and Maintainability Model
Authors: Gomes Jerônimo , Neto Miguel Mattar , Maturana Marcos Coelho , Oliveira Patricia
Published: December 2023

The main objective of this work is to present a methodology for the development of a Reliability Assurance Program (RAP) specific to a PWR experimental nuclear installation, through the analysis of the installation and the development of a preliminary RAP subsidized by a Reliability, Availability and Maintainability (RAM) model. The study of an evaluation was carried out in the long-term decay heat removal of the studied experimental plant, whose data were used for application of the RAP. The necessary steps for applying the developed RAP are followed, using the data from the assessment of the studied plant, resulting in a list of components of significant risk for the Program, and in the following steps of sending the list to the experts panel, ranking of SSCs by the panel and development of the final list of significant risk SSCs for using the list in the optimization of the plant. The RAP subsidized by a RAM model will be able to work with the logical relationships between each component of the plant for their effects on energy generation and with the quantitative prediction of the magnitude of each contributor to the occurrence of high-level events, and the developed methodology can be applicable throughout the experimental plant. In this way, it will be possible to implement the RAP in the plant, which will provide a structured way to meet the regulatory requirements for its licensing. Also, it will be possible to complement the plant safety analysis report, which must contain the RAP.
Evaluation of Ki67, Bax, Bcl-2 and KIT in canine cutaneous mast cell tumours and their relationship with histopathology and prognosis
Authors: Aytemiz Danyer Işıl , Gürel Aydın
Published: December 2023

Canine cutaneous mast cell tumours (CCMCTs) are common in dogs and exhibit many unpredictable behaviors. This study aimed to encourage pathology laboratories in developing countries to routinely assess prognosis by applying commonly used histopathological grading systems and immunohistochemistry (IHC) markers. We performed histological grading according to both the Patnaik and Kiupel systems, determined the mitotic count (MC) and carried out IHC for the detection of Ki67, Bax, Bcl-2 and KIT in 54 CCMCT cases. MC was associated with both grading systems in terms of survival following diagnosis and prognostic factors differed among cases categorized by the cut-off value of 5. KIT patterns were associated with grading systems and MC. The cohort with pattern II had a lower survival rate than those with patterns I and III. Ki67 was associated with survival when evaluated over the cut-off value of 0.018. Bax expression was associated with both grading systems. Median survival time was longer in patients with lower Bax expression level. Immunohistochemical detection of KIT, Ki67 and Bax improves histopathology in predicting the prognosis. If IHC is unavailable, reports regarding MC and values from both grading systems are the most effective, convenient and cost-effective way to provide the most reliable prognostic data and guidance for the clinicians.
Ewaluacja systemu wynagradzania jako element zrównoważonego zarządzania kapitałem ludzkim – na przykładzie call center
Authors: Beck-Krala Ewa , Stańczyk Izabela , Kornik Roman
Published: December 2023

Celem artykułu jest analiza efektywności systemu wynagrodzeń w wybranym call center z wykorzystaniem wielowymiarowego modelu spójnego z wartościami zrównoważonego zarządzania kapitałem ludzkim. Analizowany przypadek dotyczy firmy, która działa na rzecz dużego ogólnopolskiego operatora telekomunikacyjnego. W artykule poruszono zagadnienia dotyczące systemu wynagradzania w organizacji oraz dotychczasowych modeli badania tej efektywności. Analizę przeprowadzono, opierając się na wielowymiarowym modelu badania efektywności wynagrodzeń. Do realizacji celu badania wykorzystano metodę analizy dokumentów zastanych, bazując na dostępnych dokumentach związanych z wynagrodzeniem pracowników, danych finansowych, a także badania ankietowe i wywiady z pracownikami call center. Na podstawie przeprowadzonych badań można stwierdzić, że system wynagrodzeń jest efektywny. Analizując poszczególne wymiary badania, można zauważyć, że system wspiera strategię biznesową firmy, a wykorzystane wskaźniki ilościowe wskazują na efektywność kosztową systemu. Z kolei porównania rynkowe pozwalają stwierdzić konkurencyjność całkowitego pakietu wynagrodzeń. Wyniki badań sondażowych pokazały ogólne zadowolenie pracowników z systemu oraz obszary, które wymagają dalszego doskonalenia.
Zastosowanie technologii SMAC/BRAID w procesie zakupowym przedsiębiorstwa
Authors: Kulikowska Agata
Published: December 2023

W artykule przedstawiono możliwości zastosowania technologii SMAC/BRAID w procesie zakupowym. Celem opracowania jest ocena zastosowania technologii SMAC/BRAID w procesie zakupowym przedsiębiorstwa. Badania przeprowadzono, opierając się na krytycznym przeglądzie literatury oraz wynikach badania pilotażowego. Artykuł ma charakter praktyczny. Przeprowadzone analizy dowiodły, że integracja technologii SMAC/BRAID stwarza nowe środowisko pracy umożliwiające poprawę jakości komunikowania się, transparentność procesu, a w szczególności usprawnienie procesu podejmowania decyzji. Korzyści, jakie płyną z digitalizacji procesu zakupowego, to: oszczędność czasu, obniżenie kosztów, uwolnienie pracowników od wykonywania rutynowych czynności, poprawa efektywności procesów poprzez minimalizację liczby błędów popełnianych przez pracowników, szybsza reakcja na sytuacje awaryjne, szybszy dostęp do informacji, uszczelnienie w zakresie wydatków, standaryzacja procesów i eliminowanie rozproszonej odpowiedzialności, a także rozwój kompetencji cyfrowych pracowników.
Bariery współpracy pomiędzy regulatorem a przedsiębiorstwami w zakresie regulacji z perspektywy ekonomii behawioralnej
Authors: Szkudlarek Piotr
Published: December 2023

Celem artykułu była ocena znaczenia barier we współpracy pomiędzy regulatorem a przedsiębiorstwami w zakresie regulacji z perspektywy ekonomii behawioralnej. Do osiągnięcia celu badawczego wykorzystano wyniki badań ankietowych przeprowadzonych w urzędach regulacyjnych w Polsce: w Urzędzie Komunikacji Elektronicznej (UKE, n = 107) oraz w Urzędzie Regulacji Energetyki (URE, n = 157). Wyniki badania wykazały relatywnie większe znaczenie barier dotyczących skłonności do ryzyka, oceny rynku i wyboru narzędzia regulacji, a także braku partnerskich stosunków współpracy i zaufania. Jednocześnie badani wskazali na relatywnie mniejsze znaczenie braku potrzeby współpracy, zniechęcania do współpracy i nieuczciwości działań. W kilku przypadkach stwierdzono istotne statystycznie różnice w ocenie tych barier pomiędzy urzędnikami UKE i URE. W analizie barier z perspektywy ekonomii behawioralnej wskazano na znaczenie teorii perspektywy, heurystyki zakotwiczenia, efektu ramowania, efektu nadmiernej pewności, efektu status quo oraz na zjawiska szumu.
ESTUDO HIDRODINÂMICO DE REATOR UASB DE PEQUENA ESCALA POR DINÂMICA DE FLUIDO COMPUTACIONAL (CFD): SIMULAÇÃO E VALIDAÇÃO
Authors: Carvalho Rocha Vinícius , Nataline Simões Andreza , Eloísa Diniz dos Santos Carla , Cleto Pires Eduardo
Published: December 2023

Um reator UASB em pequena escala foi modelado para avaliar seu comportamento hidrodinâmico e comparar simulações de CFD com resultados experimentais obtidos em escala de laboratório. Foram realizadas simulações usando o Ansys® CFXTM com duas taxas de fluxo diferentes: A) 26,68 e B) 4,0 l d-1. O volume do reator era de 1,5 litros, com um volume útil de 1,38 litros. Além das simulações de CFD, foram realizados testes hidrodinâmicos com injeção de traçador, tanto experimentalmente quanto nas simulações. Foram obtidas curvas de distribuição do tempo de residência (RTD) e o modelo de número de tanques em série (NTIS) foi usado para determinação do comportamento hidrodinâmico. Os valores de NTIS calculados usando simulações de CFD foram 5,55 e 4,76, para as taxas de fluxo A e B, respectivamente. Para a análise experimental, os valores de NTIS foram 6,67 e 5,54, para as taxas de fluxo A e B, respectivamente. O teste U de Mann-Whitney foi realizado para confirmar a similaridade entre as simulações de CFD e os testes experimentais. Os resultados do teste U de Mann-Whitney não mostraram diferenças estatisticamente significativas entre as simulações de CFD e os dados experimentais. Pode-se concluir que as simulações de CFD são válidas e podem ser usadas para analisar o comportamento hidrodinâmico dos reatores UASB.
SURVEY AND TEMPORAL AND EVOLUTIONARY ANALYSIS OF LINEAR WATER EROSION ON A SAMPLE HILLSLOPE OF THE LEOPOLDO RIVER
Authors: Francisco Matheus Ribas , De Oliveira Ana Laura Pascucci , Furegatti Simone Andrea
Published: December 2023

The article presents a temporal and evolutionary analysis of linear water erosion, as from a survey of a sample hillslope of the Leopoldo river, located in the municipality of Agudos (SP). The survey was elaborated from satellite images made available by Google Earth, which allowed to identify the main characteristics of erosive features. The analyzed characteristics are: slope position, length, width, line of inclination, shape, evolutionary stage, incision system, possible origin, curvature longitudinal and transversal. So, the article made it possible to study the erosions’ behavior and the relationship with local morphology.
Retrospective analysis of an intercultural paradigmatic shift in the philosophical and educational thought in Ukraine in the second half of the 19th and the beginning of the 20th century
Authors:   National Academy of Educational Sciences of Ukraine, Saukh Petro
Published: December 2023

The article reveals the peculiarities of intercultural paradigmatic shifts in the philosophical and pedagogical thought of Ukraine in the second half of the 19th and early 20th centuries. It has been proven that Ukrainian philosophical and educational thought (despite the fact that it objectively bordered with the Russian one and actively fits into the pan-European philosophical and pedagogical algorithm) had a number of specific national concrete-cultural features and colours. Its image was closely related to the formation of the “soul of the Ukrainian people”, which was formed by a combination of mental, cultural and moral characteristics. The matrix of paradigmatic shifts in philosophical and pedagogical thought of this period was focused on the semantic, ontological dimensions of human spirituality, pedagogical factors of personality development, the formation of the national discourse of educational science as a certain theoretical integrity. It has been confirmed that the philosophical and pedagogical thought, which unfolded within the framework of socio-political development of scientific and educational institutions and which performed a human-creating function in culture, was characterized by a tendency to create an intercultural “philosophy of teaching and education”, which became the background for pedagogical constructions of our (that?) time. On this basis, the most important constants in the development of education of this period are determined, which have heuristic significance and are in many respects compliant with modern educational transformations, which require comprehensive understanding, primarily from the standpoint of pedagogical anthropology.
Pre-service teacher self-efficacy in Poland and Slovakia
Authors:   Casimir Pulaski University of Radom, Faculty of Philology and Pedagogy, Zamkowska Anna , Depešová Jana ,   Constantine the Philosopher University in Nitra, Faculty of Education, Sałata Elżbieta ,   Casimir Pulaski University of Radom, Faculty of Philology and Pedagogy
Published: December 2023

The level of preparation of teachers before they enter the profession is an important factor affecting the level of culture of future generations and, consequently, the society as a whole. This preparation requires not only the proper implementation of the curriculum, but also the acquisition of self-efficacy skills. So far, the self-efficacy of pre-service teachers has been studied with respect to different variables. However, there is a lack of satisfactory comparative research among students from Poland and Slovakia, the countries of slightly different approach to preparation of pre-service teachers. To fill this gap, a comparative study of 355 Polish and 198 Slovakian university students was conducted using Tschannen-Moran and Woolfolk Hoy Teachers’ Sense of Efficacy Scale. The purpose of the research was to determine which variables, including the country (Poland, Slovakia), course, form, year of study and participation in the field experience correlate significantly with the sense of efficacy of pre-service teachers. The obtained results indicate a satisfactory consistency between the Polish and the Slovakian version of the Teachers’ Sense of Efficacy Scale. The research revealed a significantly higher self-evaluation among Polish university students and students of early childhood education. Part-time students with field experience evaluated themselves higher than full time students. The results emphasize that it is important to place high demands on future teachers and create appropriate conditions to improve their teaching and self-evaluative abilities.
Towards axiological maturity – the implementation and fulfilment of values by academic youth from Poland, the Czech Republic, Slovakia and Ukraine
Authors:   University of Silesia in Katowice, Faculty of Arts and Educational Science, Ogrodzka-Mazur Ewa
Published: December 2023

The outlining of the values appreciated by academic youth and their perception of the possibilities of implementing and fulfilling them was based on the international comparative research conducted in 2019–2021 in the PolishCzech-Slovak-Ukrainian borderland. In the pedagogical analysis undertaken in the study of this subject matter, some theoretical and methodological conceptualizations were applied, which referred to: (1) Ronald F. Inglehart’s concept of changes of values, (2) the objectivistic approach to values and axiological maturity according to Adam Węgrzecki and (3) comparative analysis in international studies. Comparing the declarations of student groups in the investigated environments reveals significant differences in all value assessments, except for the implementation of moral values and a respectable life. The analysis and interpretation of the collected empirical material also indicate that the image of university students’ axiological preferences is characterized – in the context of Inglehart’s theory – mainly by secular-rational authority and post-materialism aimed at achieving a particular quality of life.
Interculturalism in Polish schools according to teachers from borderlands
Authors:   University of Silesia in Katowice, Faculty of Social Sciences, Młynek Patrycja , Andruszkiewicz Fabian ,   Opole University, Faculty of Social Sciences, Kulik-Grzybek Danuta ,   Czestochowa University of Technology, Foreign Language Center
Published: December 2023

Global cultural exchange is a well-known, boundless phenomenon. Therefore, it is fundamental for countries to promote mutual understanding and tolerance of cultural diversity, to prevent stigmatization and social hermetization from migrant backgrounds, and to foster social inclusion, thus fulfilling the assumptions of sustainable development. Polish society is considered to be relatively homogenous in terms of culture, however, the increasing influx of immigrants, especially from Eastern Europe, poses a new challenge for its national schooling system and multicultural education. That is why the aim of the article was to verify the state of preparation of Polish schools for multicultural education, mutual attitudes of the participants of the educational process, and the relationships between them, as well as to indicate dependency between parents, students, and teachers. The article presents the results of quantitative research carried out in a group of early childhood education teachers from border regions. The results of the conducted research showed the state of intercultural education in Polish schools before the start of the war between Russia and Ukraine. The study is barely the attempt of monitoring the condition of intercultural education, especially in the current “new multicultural reality” in Polish schools.
Expanding educational spaces of cooperation and social relations through Technology-enhanced International Virtual Exchanges
Authors:   University of Rzeszów, College of Humanities, Sokol Mariana , Zhang Jie ,   SUNY Brockport University, School of Education, Health & Human Services, United States
Published: December 2023

Technology-enhanced international virtual exchanges (IVE), or Collaborative Online International Learning (COIL), provide educators and students with the access and tools to connect with the world through collaboration with colleagues and peers in a global context (SUNY COIL Center, “Welcome”, n.d.a). In the IVE courses, students in different countries work together to broaden not only their academic knowledge, but also digital literacy, critical thinking, problemsolving, teamwork, and communication skills (Werner, 2015). In this study, technology-enhanced IVE are introduced and the benefits of IVE for educators and students are explored. Some concrete examples are also shared of how two professors from Ukraine and the United States reflected on the course of collaboration with our French partner professor to co-plan and co-teach a technology-enhanced IVE course in order to offer sustainable international education and provide students with the opportunities to gain diverse cross-cultural, cross-linguistic, and cross-disciplinary experiences, to demonstrate communication skills using technology, and to improve their intercultural competence.
Implementation of the Positive Early Childhood Education Curriculum for students with migration experience – the assumptions and directions of action
Authors:   University of the National Education Commission in Krakow, Faculty of Education and Psychology, Czaja-Chudyba Iwona
Published: December 2023

Migration puts children in a difficult situation – it takes away their stability and constancy of everyday events and plucks them from a safe environment. The purpose of the article is to present the main assumptions and innovative ideas related to the author’s Positive Early Childhood Education Curriculum, as well as indicating the forms of work with students with migration trauma experience. The applied method was the educational project description. The extraordinary nature of the Curriculum is exhibited in the relocation of metatheoretical assumptions – from pedagogy of “lack” to pedagogy of “growth”. Therefore, it is recommended that the child’s well-being should be nurtured (M. Seligman, A. Antonovsky) alongside the development of intercultural proximity and “soft competences”, which are of importance for students with trauma experiences. The Curriculum allows as well for acquiring teacher’s self-awareness. It has been indicated how to implement the Curriculum assumptions – positivity, optimality, balance, and prospectivity for students with various cultural and biographical backgrounds. Special attention is devoted to strengthening the resilience in students with migration experiences and to the directions of actions to enable them the emotional, socio-cultural, instrumental, material and procedural, systemic, environmental and preventive support.
Chinese culture of interdependence and relations in education – guanxi in school practice
Authors:   Adam Mickiewicz University in Poznań, Faculty of Educational Studies, Mańkowska Anna
Published: December 2023

The aim of the article is to discuss the Chinese educational culture in the context of the pursuing guanxi tradition. The article answers the question what guanxi is and how it is applied in the Chinese educational system. The subject of research is the educational system and guanxi culture and its practical implications. In the article, the existing studies are used of Chinese and other foreign authors. The qualitative research method involves analyses of secondary sources which outlined the methods and principles of operation of the old Chinese tradition of regulating social relationships in education in the network of three-sided personal relations: school-home, parent-teacher, and students-teachers.
PASSIVE THERMAL MANAGEMENT OF PHOTOVOLTAIC MODULES USING LATENT HEAT STORAGE SYSTEM WITH METALLIC MESH LAYERS AND MULTI-METAL SPINEL OXIDE NANOPARTICLES
Authors: Gürbüz Emine Yağız , Moussaoui Haytem , Kusun Barış , Tuncer Azim Doğuş
Published: December 2023

Passive thermal management of photovoltaic (PV) panels is an effective and low-cost method for reducing the surface temperature and improving the power output of these systems. In the current study, it is aimed to upgrade the efficiency of a PV system using a latent heat storage system with metallic mesh layers and multi-metal spinel oxide nanoparticles. The experimental part of this work contains two stages. In the first stage, three PV systems including an unmodified PV, an LHSS (only paraffin)-integrated PV system, and an LHSS-integrated PV system modified with metallic mesh layers have been considered. As a result of the initial test, the PV system with mesh layers added LHSS gave the best performance results. In the second experiment, the mesh layer-integrated LHSS of the PV system was modified with MgOAl2O3 nanoparticles for enhanced thermal conductivity and was compared with the PV system with mesh layer-integrated LHSS containing only paraffin. According to the experimental results of this work, applying different types of LHSS configurations significantly reduced the surface temperature of the PV panel. Average module efficiencies for all cases were attained within the range of 7.80--.16%. The overall outcomes of the present work showed that using an LHSS with MgOAl2O3 nanoparticles-doped paraffin and metallic mesh layers upgraded the normalized power output efficiency and performance ratio of the unmodified system as 17.43% and 15.72%, respectively.
REHBERLİK VE ARAŞTIRMA MERKEZLERİNİN İŞ YÜKÜ: DURUM ÇALIŞMASI
Authors: KARAKAYA İlker , ÖZEN Fatmanur
Published: December 2023

Bu araştırmanın amacı, Rehberlik ve Araştırma Merkezlerinin (RAM) görev, işleyiş, kurum içi çalışma sistemlerini mevzuat ve planlar çerçevesinde tanımlayarak Samsun-Bafra RAM örneğinde iş yüklerini tespit etmek ve RAM’ların iş yüklerini azaltma ve verimliliklerini artırmak için önerilerde bulunmaktır. Araştırma durum araştırmasıdır. Araştırmada ilgili metinler (mevzuat, kalkınma ve eğitim vizyonu belgesi) doğrultusunda RAM’ların iş ve sorumluluk alanı tespit edilmiş, bu sorumlulukları içeren başlıklarla Bafra RAM 2022 yılına ait iş yükü sayısal olarak tespit edilmiştir. Bafra RAM’da görev yapan uzmanlar ile yüz yüze görüşmelerde iş yükünün yansıları ve iş yükünün azaltılabilmesi için görüşler tespit edilmiştir. Araştırma verilerinin tümevarımcı süreçte birlikte analiz edildiği bu araştırmanın sonuçları RAM’ların özel eğitim, rehberlik, araştırma ve eğitim olmak üzere dört faaliyet alanının bulunduğunu göstermektedir. Tüm verilerin bu dört faaliyet alanına ait eksenlerde değerlendirildiği sonuçlar RAM’larda faaliyet alanlarından en çok özel eğitim hizmetleri ile ilgili eğitsel tanılama ve değerlendirme uygulamalarına çaba harcandığını, özel eğitim hizmeti faaliyetlerine ayrılan zaman nedeniyle de diğer faaliyetlere gerekli zamanın ayrılamadığını göstermektedir. Araştırmaya katılanlar RAM’lara ait iş yükünün azaltılması için bürokratik ve yönetsel öneriler başlıkları altında analiz edilen bir grup öneride bulunmuşlardır. Araştırma sonuçları, ilgili araştırma sonuçları ile birlikte değerlendirilerek RAM’ların iş yükünü azaltacak, verimliliklerini artıracak önerilerde bulunulmuştur.
Sanatın Haz ve Arzu Ötesi Potansiyeli: Jouissance
Authors: SELMANPAKOGLU Ceren
Published: December 2023

Haz ve arzu kavramlarının temel tanımları içinde yer alan ‘istek’ kavramı, insanın varlık-eksikliği içinde kendini oldurma ve tamamlama çabasından kaynaklanmaktadır. Yaratma edimi ile yönelimlenen istek elde edildiğinde haz, yani tatmin gerçekleşir. Sanatçı, gerçekliği yansıtma tekrarından mastürbatif bir tatminle haz almaktadır. İzleyici de böylesi bir yapıtla karşılaştığında bildiği aynı simgesel yapıyı alımladığında haz almaktadır. Arzuda ise istek tamamlanamaz, yani istek devam eder. Çünkü arzu tatmin edilebilir değildir; öznenin eksiğini gidererek onun imgesel bütünlüğünün gerçekleştirilmesini sağlayacağı varsayılan imgesel objet-petit-a ile yani kayıp arzu nesnesi ile karakterize edilir. Sanatçı üretirken, izleyici de alımlarken yapıtta aktarılan ve alımlananlar ile hem tatminin sağlandığı bir haz ilişkisi hem de o hep aranan kayıp arzu nesnesi elde edilemediğinden ve edilemeyeceğinden arzu ilişkisi yürütülmektedir. Bu ikilik ortaya bir paradoks çıkarmaktadır. Bu nedenle, bir sanat yapıtında aslında bu iki kavramın da ötesinde gerçekleşen bu şey’i tarif eden üçüncü bir terimin gerekliliği ortaya çıkmıştır. Bunun için de bu araştırmada sanat, psikanaliz ve felsefe teorileri ilişkilendirilerek bir değerlendirme yapılmıştır.

Bu Şey, imgesel olarak kurgulanan yapıtın simgeselleştirilirken aktarılamayan, gösterilemeyen fark ya da eksiğin sanatçı ve izleyiciye kendi kendilerini feshetmeleri için sataşmasıdır: Buna göre, onlarda potansiyel olarak bulunan ve hem tamamlanamayan bir elde etmeyi hem de tamamlanamayışı feshetmekten duyulan coşkuyu tarif edebilen bu üçüncü terim Lacan’ın jouissance açıklamasında bulunmuştur. Yapıtın jouissance üzerinden işlemesi halinde, önce sanatçının, akabinde de izleyicinin kişiliklerinin tüm düzeylerinde gerçekliği ayrıştırma arzusunun devreye girdiği anlamına gelmektedir. Böylelikle yapıt üzerinden kendi kurmacalıklarının farkına varıp onu feshederek kendi yıkımları ile yüzleştiklerinde duydukları coşku jouissance olacaktır: Sürekli şimdi ve burada ve hiçbir yerde olmanın “etkili bozgunluğunu” bir sanat yapıtında duyumsamanın coşkusu olarak jouissance.
Visium Direct Mount Fresh Frozen -- University of Minnesota TMCs v1
Authors: J Niedernhofer Laura
Published: December 2023

The Visium Spatial Gene Expression Solution measures the total mRNA in tissue sections and requires a Visium Spatial slide with intact tissue sections as input. This protocol outlines methanol fixation, Hematoxylin & Eosin (H&E) staining, and imaging of tissue for use with 10x Genomics Visium Spatial protocols. Fixed and stained tissue sections are inputs for the downstream Visium Spatial Tissue Optimization and Visium Spatial Gene Expression workflows. Tissue sections are processed with Visium Spatial Gene Expression assay performed by the University of Minnesota Imaging Center and sequenced by the University of Minnesota Genomics Center.
SOP: cell culture methods for non-model organisms v1
Authors: Riesgo Ana
Published: December 2023

Acquisition of somatic cells from vertebrates for cell cultures is well stablished in the literature. However, some vertebrate taxa like amphibians prove to be challenging mostly because there is a higher chance of contamination in this group or because the cells do not survive for long periods preventing to be cryopreserved. For invertebrates, the challenge is even greater and so far, the protocols tested have not proven satisfactory and are still being developed. Therefore, the SOPs for invertebrates presented below are still in the testing phase.
ASAP protocol: Crystallization of Enterovirus A71 3C protease (PDB code 8CNY) v1
Authors: not provided ryan.lithgo , Marples Peter , not provided daren.fearon , Koekemoer Lizbé
Published: December 2023

The crystallization protocol and buffer conditions used to obtain Enterovirus A71 3C protease crystals. The crystal structure was depostited to RCSB PDB with code 8CNY.
Doctrinal Debate on the Age of Contracting of Marital in Ibero-America
Authors: Aboi Diego , Salido López Mercedes
Published: December 2023

In this article, I intend to identify, within the frame of the semiotic theories of C.S. Peirce and U. Eco, some indications that may help to shed light on a remarkable phenomenon of constitutional interpretation, namely the influence exerted, in the determination process of the constitutional provisions which attribute fundamental rights, by the set of beliefs, expectations, purposes, etc., sedimented within a socially oriented linguistic practice. Through this operation of analogical transposition, I aim to highlight how the identification of the theoretical-doctrinal backgrounds related to the complex of ethical-political conceptions incorporated by the constitutions is strongly influenced by various elements of an intra- and extra-textual nature. Furthermore, by placing the interpretative processes in a broader hermeneutic-semiotic framework that considers legal cases as sign functions, the text seeks to demonstrate in a relatively easy-to-understand manner that the theoretical complications present in the legal field are ultimately not dissimilar to those found in any other interpretative activity that involves the use of a natural-historical language.
Renate Wagner-Rieger und Barockforschung in Kroatien
Authors: Botica Dubravka
Published: December 2023

Die Forschungen von Renate Wagner-Rieger haben die Entwicklung der Kunstgeschichte im zentraleuropäischen Raum wesentlich angeregt, so auch in Kroatien, und dies gilt vor allem für die Architekturforschung. Die Texte von Wagner-Rieger aus den 1960er und 1970er Jahren hätten hochwahrscheinlich den Impuls für die Entwicklung der Barockforschung, besonders in Nordkroatien, gegeben. Als die wichtigsten Thesen von Wagner-Rieger, die in den kroatischen Forschungen zu beobachten sind, ist die Typologie der Jesuitenkirchen, die Đurđica Cvitanović (1924-2009) an Beispielen der Jesuitenarchitektur in Kroatien entwickelt hat und der Stilpluralismus als das wichtigste Stilmerkmal der Kunst der mariatheresianischen Epoche, bearbeitet in Texten von Anđela Horvat (1911-1985).
„Eine Verflechtung von Strömungen“
Authors: Mader-Kratky Anna
Published: December 2023

Der Vortrag „Die österreichische Architektur in ihrer Entwicklung zur Moderne” gab 1959den Ausschlag, dass sich Renate Wagner-Rieger mit der Architektur des 19. Jahrhunderts zu beschäftigen begann, war ihr aber auch Anlass, verstärkt zu deren Voraussetzungen in der Zeit um 1800 zu publizieren. Sie charakterisierte die Phase von 1770 bis 1830 als „Verflechtung einer ganzen Reihe von Strömungen” in der Wiener und österreichischen Architektur und arbeitete erstmals den Stilpluralismus dieser Epoche heraus.
Multidisciplinary approach to the treatment of a patient with juxtarenal, abdominal aortic aneurysm and renal cell cancer
Authors: Chupin A. V. , Masalimov N. R. , Baitman T. P. , Gritskevich A. A. , Kulbak V. A. , Miroshkina I. V. , Kondratyev E. V. , Stepanova Ya. A. , Timina I. E.
Published: December 2023

Currently, strategies for the management of tumor diseases of the urinary tract in combination with cardiovascular pathologies are controversial. In domestic literature, only isolated reports are found concerning the treatment of combined oncological and cardiovascular pathologies, and the global experience is limited to individual clinical observations and small retrospective series, primarily describing the experience of individual centers. The current challenge for specialists is to establish the ideal treatment sequence with regard to the optimal timing of each surgical procedure and the initial priority of treatment, or the possibility of performing them simultaneously. The article presents a case of successful simultaneous surgical intervention for juxtarenal abdominal aortic aneurysm (AAA) and renal cell carcinoma (RCC) of the left kidney. The patient underwent resection of an abdominal aortic aneurysm with the replacement of the left renal artery, resection of the left kidney under pharmaco-cold ischemia, with thrombectomy from the renal vein. The postoperative period proceeded satisfactorily. After 6 months, on the control computed tomography of the abdominal organs with contrast enhancement (CT) of the abdominal cavity with CU, the prosthesis of the abdominal aorta and the left renal artery are functioning. According to color duplex scanning (CDS) of the renal vessels, the blood flow in the left kidney is preserved to the periphery with normal speed indicators. No data on the recurrence of the oncological process were received.
CORONET online risk assessment tool and Charlson comorbidity index in predicting fatalities in cancer patients with COVID-19
Authors: Rusanov A. S. , Sekacheva M. I. , Tyazhelnikov A. A.
Published: December 2023

Purpose of the study. Сomparing and evaluating the prognostic potential of the CORONET online risk assessment tool and the Charlson Comorbidity Index in predicting mortality in cancer patients with COVID-19.

Materials and methods. The results are drawn from the data of 168 case histories of cancer patients who were undergoing inpatient treatment for COVID-19 at the University Clinical Hospitals of Sechenov University between March 2020 and February 2022. The study was conducted as part of the program of the world-class research center “Digital Biodesign and Personalized Healthcare” of Sechenov University, with participation in the ESMO-CoCARE Registry project. Patients with a history of solid or hematologic malignancies were included in the study; their treatment period before the study was 5 years or less. The age ranged from 37 to 100 years, the median age was 69 years. The CORONET online risk assessment tool and the Charlson comorbidity index were used to objectify the severity of multimorbidity status and prognosis of fatal outcomes in cancer patients with COVID-19.

Results. It was demonstrated that statistically significant effects on the prognosis of mortality in patients with cancer were: age, percentage of saturation on admission, treatment in intensive care units (ICU), National Early Warning Score 2 (NEWS2) distress syndrome severity scale score, computed tomography (CT) assessment of disease course severity, decreased blood albumin and platelet counts, and increased blood neutrophil counts in both categorical and immediate indicator value formats. In addition, it was determined that as the number of comorbidities increased, the probability of mortality increased significantly, odds ratio (OR) = 2.162 (CI 95 % 1.016–4.600; p = 0.045). The CORONET calculator score yields one of the highest OR values among all established statistically significant predictors,

20.410 (CI 95 % 4.894–85.113; p < 0.001). For oncopathology in COVID-19 patients, the Charlson index score shows statistical significance as a predictor of mortality, OR =1.396 (CI 9 5 % 1.105–1.765; p = 0.005).

Conclusion. The obtained advantages in using the CORONET online decision support tool over the Charlson comorbidity index in predicting mortality in cancer patients with COVID-19 are recognized as convincing.
Indicators of free radical oxidation in neutrophils of patients with primary and recurrent soft tissue sarcomas
Authors: Goroshinskaya I. A. , Kaplieva I. V. , Frantsiyants E. M. , Vashchenko L. N. , Lapteva T. O. , Ausheva T. V. , Nemashkalova L. A. , Kachesova P. S. , Kozel Yu. Yu.
Published: December 2023

Purpose of the study. To carry out a comparative analysis of lipid peroxidation intensity and antioxidant system indices in blood neutrophils of patients with primary and relapsed soft tissue sarcomas (STS) depending on sex and age.

Patients and methods. Of the 81 patients included in the study, 48 had primary STS, 5 patients with continued growth, and 28 patients with recurrent STS. The patients were divided by sex and age; the level of lipid peroxidation products, superoxide dismutase (SOD) activity, total peroxidase activity (TPA), glutathione peroxidase (GPx) activity and reduced glutathione (RG) content in blood neutrophils were investigated by conventional spectrophotometric methods. The comparison groups (donors) consisted of 12 men and 17 women divided into the same age subgroups: ≤ 45 years and > 45 years.

Results. In donors, there was a multiple decrease in the SOD/TPA ratio with age, especially in women, and in men this was accompanied by an age-related decrease in GPx activity. In primary sarcomas in older women and in men with continued growth and recurrence, there was an increase in diene conjugates (DC). In men over 45 years of age, there was an increase in SOD, TPA, and GPx. Women of the older age group were characterized by activation of SOD and GPx, expressed in the relapsed process to a significantly greater extent than in men, and an increase in RG was observed in women. The increase in both components of the glutathione system and SOD activity was especially significant in the development of relapses in women for periods exceeding three years, which was accompanied by a decrease in DC content. Conclusions. Neutrophils are characterized by an increase in DC content in patients of both sexes in the older age group with primary and recurrent STS, with its highest content in men with continued growth and relapses. GPx activity, increased in both men and women in the older age group in all variants of STS development, may play an important role in the antioxidant protection of blood cells in STS. Thus, the most pronounced activation of GPx, accompanied by a maximum increase in reduced glutathione and activation of SOD, contributes to a decrease in the level of DC and the absence of MDA increase in women with slow development of recurrences.
Molecular and cellular aspects of the impact of secondary metabolites from common barberry and hybrid goat’s rue on the HeLa cell line
Authors: Zlatnik E. Yu. , Enin Ya. S. , Burov O. N. , Bondarenko E. S. , Sagakyants A. B. , Kutilin D. S. , Dzigunova Yu. V. , Ishonina O. G. , Shalashnaya E. V. , Ushakova N. D,
Published: December 2023

Purpose of the study. To isolate and verify pure fractions of secondary plant metabolites contained in B. vulgaris (L.) and P. hibridus (L.), as well as to conduct a model experiment and molecular genetic study to evaluate their cytotoxic effect in vitro on the HeLa cell line.

Materials and methods. The isolation and verification of all compounds used in the experiment were carried out using column chromatography and nuclear magnetic resonance methods at the Department of Natural Compounds, Faculty of Chemistry, Southern Federal University. Subsequently, an experiment was conducted using cultural and molecular methods on the HeLa cell line in three repetitions for each test compound; after incubation with them, the numbers of dead cells were counted on the automated NanoEnTek JuliFl counter, and the numbers of cells in apoptosis were measured by flow cytometry on the BD analyzer FACS Canto II. The level of copy number variation and expression of genes responsible for apoptosis were assessed by real-time PCR (RT-PCR). In total, three substances were studied, with two concentrations (4 and 12 μg/ml) and two exposures (24 and 72 hours) for each of them.

Results. In the first stage of the study, we isolated and verified the berberine alkaloid extracted from the roots of B. vulgaris (L.), as well as 2,4-dihydroxy-2,5-dimethylfuran-3(2H)-one and 2,2,8-trimethyldecahydroazulene-5,6-dicarbaldehyde from P. hibridus (L.). The subsequent stage of the study demonstrated the maximal cellular death under the action of berberine at a 72-hour exposure. However, the RT-PCR assessment of the copy number variation and expression of the CASP8, CASP9, CASP3, BAX, BCL2, TP53 and MDM2 genes revealed the presence of apoptosis initiation in tumor cells at the molecular level under the action of all the studied compounds: both berberine and furan and azulene derivatives derived from P. hibridus (L.).

Conclusion. All compounds used in the experiment exhibited a cytotoxic effect on the HeLa cell line. Berberine alkaloid showed the most pronounced cytotoxic effect on the HeLa line as recorded by all methods used in the study. Terpenoids 4-dihydroxy-2,5-dimethylfuran-3(2H)-one and 2,2,8-trimethyldecahydroazulene-5,6-dicarbaldehyde, when exposed to the HeLa line, caused an increase in the copy number variation and expression of the CASP9, CASP3 loci, which are among the main activators of apoptosis. They also influenced the expression of TP53 and MDM2 loci.