bluuebunny/crossref_metadata_2025 huggingface dataset:
trans-Fatty acids facilitate DNA damage-induced apoptosis through the mitochondrial JNK-Sab-ROS positive feedback loop
Authors: Hirata Yusuke , Inoue Aya , Suzuki Saki , Takahashi Miki , Matsui Ryosuke , Kono Nozomu , Noguchi Takuya , Matsuzawa Atsushi
Published: February 2020

trans-Fatty acids (TFAs) are unsaturated fatty acids that contain one or more carbon-carbon double bonds in trans configuration. Epidemiological evidence has linked TFA consumption with various disorders, including cardiovascular diseases. However, the underlying pathological mechanisms are largely unknown. Here, we show a novel toxic mechanism of TFAs triggered by DNA damage. We found that elaidic acid (EA) and linoelaidic acid, major TFAs produced during industrial food manufacturing (so-called as industrial TFAs), but not their corresponding cis isomers, facilitated apoptosis induced by doxorubicin. Consistently, EA enhanced UV-induced embryonic lethality in C. elegans worms. The pro-apoptotic action of EA was blocked by knocking down Sab, a c-Jun N-terminal kinase (JNK)-interacting protein localizing at mitochondrial outer membrane, which mediates mutual amplification of mitochondrial reactive oxygen species (ROS) generation and JNK activation. EA enhanced doxorubicin-induced mitochondrial ROS generation and JNK activation, both of which were suppressed by Sab knockdown and pharmacological inhibition of either mitochondrial ROS generation, JNK, or Src-homology 2 domain-containing protein tyrosine phosphatase 1 (SHP1) as a Sab-associated protein. These results demonstrate that in response to DNA damage, TFAs drive the mitochondrial JNK-Sab-ROS positive feedback loop and ultimately apoptosis, which may provide insight into the common pathogenetic mechanisms of diverse TFA-related disorders.
Muscle Injury Induces Postoperative Cognitive Dysfunction
Authors: Guéniot Lorna , Lepere Victoria , De Medeiros Gabriela Ferreira , Danckaert Anne , Flamant Patricia , Le Dudal Marine , Langeron Olivier , Goossens Pierre L. , Chrétien Fabrice , Jouvion Grégory
Published: February 2020

Postoperative cognitive dysfunction (POCD) is a major complication affecting patients of any age undergoing surgery. This syndrome impacts everyday life up to months after hospital discharge, and its pathophysiology still remains unclear. Translational research focusing on POCD is based on a wide variety of rodent models, such as the murine tibial fracture, whose severity can limit mouse locomotion and proper behavioral assessment. Besides, influence of skeletal muscle injury, a lesion encountered in a wide range of surgeries, has not been explored in POCD occurrence. We propose a physical model of muscle injury in CX3CR1GFP/+ mice (displaying green fluorescent microglial cells) to study POCD, with morphological, behavioral and molecular approaches. We highlighted: alteration of short- and long-term memory after muscle regeneration, wide microglial reactivity in the brain, including hippocampus area, 24 hours after muscle injury, and an alteration of central brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF) balance, 28 days after muscle injury. Our results suggest for the first time that muscle injury can have early as well as late impacts on the brain. Our CX3CR1GFP/+ model can also facilitate microglial investigation, more specifically their pivotal role in neuroinflammation and synaptic plasticity, in the pathophysiology of POCD.
Incidence of diabetes mellitus in Spain as results of the nation-wide cohort di@bet.es study
Authors: Rojo-Martínez G. , Valdés S. , Soriguer F. , Vendrell J. , Urrutia I. , Pérez V. , Ortega E. , Ocón P. , Montanya E. , Menéndez E. , Lago-Sampedro A. , González- Frutos T. , Gomis R. , Goday A. , García-Serrano S. , García-Escobar E. , Galán-García J. L. , Castell C. , Badía-Guillén R. , Aguilera-Venegas G. , Girbés J. , Gaztambide S. , Franch-Nadal J. , Delgado E. , Chaves F. J. , Castaño L. , Calle-Pascual A.
Published: February 2020

Our aim was to determine the incidence of type 2 diabetes mellitus in a nation-wide population based cohort from Spain (di@bet.es study). The target was the Spanish population. In total 5072 people older than 18 years,were randomly selected from all over Spain). Socio-demographic and clinical data, survey on habits (physical activity and food consumption) and weight, height, waist, hip and blood pressure were recorder. A fasting blood draw and an oral glucose tolerance test were performed. Determinations of serum glucose were made. In the follow-up the same variables were collected and HbA1c was determined. A total of 2408 subjects participated in the follow-up. In total, 154 people developed diabetes (6.4% cumulative incidence in 7.5 years of follow-up). The incidence of diabetes adjusted for the structure of age and sex of the Spanish population was 11.6 cases/1000 person-years (IC95% = 11.1–12.1). The incidence of known diabetes was 3.7 cases/1000 person-years (IC95% = 2.8–4.6). The main risk factors for developing diabetes were the presence of prediabetes in cross-sectional study, age, male sex, obesity, central obesity, increase in weight, and family history of diabetes. This work provides data about population-based incidence rates of diabetes and associated risk factors in a nation-wide cohort of Spanish population.
5-Nitrouracil stabilizes the plasma concentration values of 5-FU in colorectal cancer patients receiving capecitabine
Authors: Yoshida Yoichiro , Hashimoto Yasuhiro , Miyazaki Makoto , Aisu Naoya , Yamada Teppei , Kajitani Ryuji , Munechika Taro , Matsumoto Yoshiko , Nagano Hideki , Shimaoka Hideki , Komono Akira , Sakamoto Ryohei , Yoshimatsu Gumpei , Yoshimura Fumihiro , Kiyomi Fumiaki , Hasegawa Suguru
Published: February 2020

Capecitabine is selectively converted from 5′-DFUR to 5-fluorouracil (5-FU) in tumours by thymidine phosphorylase (TP). We investigated the addition of 5-nitrouracil (5-NU), a TP inhibitor, into blood samples for precise measurements of plasma 5-FU concentrations. The plasma concentration of 5-FU was measured after capecitabine administration. Two samples were obtained at 1 or 2 h after capecitabine administration and 5-NU was added to one of each pair. Samples were stored at room temperature or 4 °C and 5-FU concentrations were measured immediately or 1.5 or 3 h later. The mean plasma 5-FU concentration was significantly higher at room temperature than at 4 °C (p < 0.001). The 5-FU concentration was significantly increased in the absence of 5-NU than in the presence of 5-NU (p < 0.001). The 5-FU change in concentration was greater in the absence of 5-NU, and reached 190% of the maximum compared with baseline. A significant interaction was found between temperature and 5-NU conditions (p < 0.001). Differences between the presence or absence of 5-NU were greater at room temperature than under refrigerated conditions. 5-FU plasma concentrations after capecitabine administration varied with time, temperature, and the presence or absence of 5-NU. This indicates that plasma concentrations of 5-FU change dependent on storage conditions after blood collection.
The integrated effect of salinity, organic amendments, phosphorus fertilizers, and deficit irrigation on soil properties, phosphorus fractionation and wheat productivity
Authors: Ding Zheli , Kheir Ahmed M. S. , Ali Marwa G. M. , Ali Osama A. M. , Abdelaal Aly I. N. , Lin Xin’e , Zhou Zhaoxi , Wang Bizun , Liu Beibei , He Zhenli
Published: February 2020

Soil degradation due to global warming, water scarcity and diminishing natural resources negatively impacts food security. Soil fertility deterioration, particularly phosphorus (P) deficiency, remains a challenge in the arid and semi-arid regions. In this study, field experiments were conducted in different geographical locations to investigate the effects of organic amendments coupled with P fertilization and irrigation on soil physical-chemical properties, and the growth, yield and quality of wheat. Application of P fertilizers combined with organic amendments mitigated soil salinity, increased organic matter content, available water, hydraulic conductivity and available macronutrients, but decreased soil bulk density. Application of organic amendments slightly increased total Cd, Ni and Pb in soil, but Cd and Ni concentration was below allowable limits whilst Pb reached a hazardous level. Soil P fractions were significantly increased with the combined application of mineral P and organic amendments irrespective of salinity and irrigation. Crop growth yield and quality of wheat improved significantly in response to the integrated application of mineral P and organic amendments. In conclusion, the combination of mineral P sources with organic amendments could be successfully used as a cost-effective management practice to enhance soil fertility and crop production in the arid and semi-arid regions stressed with water scarcity and natural resource constraints.
Homologous recombination deficiency status-based classification of high-grade serous ovarian carcinoma
Authors: Takaya Hisamitsu , Nakai Hidekatsu , Takamatsu Shiro , Mandai Masaki , Matsumura Noriomi
Published: February 2020

Homologous recombination repair (HRR) pathway deficiency (HRD) is involved in the tumorigenesis and progression of high-grade serous ovarian carcinoma (HGSOC) as well as in the sensitivity to platinum chemotherapy drugs. In this study, we obtained data from The Cancer Genome Atlas (TCGA) on HGSOC and identified scores for the loss of heterozygosity, telomeric allelic imbalance, and large-scale state transitions, and calculated the HRD score. We then investigated the relationships among the score, genetic/epigenetic alterations in HRR-related genes, and the clinical data. We found that BRCA1/2 mutations were enriched in the group with HRD scores ≥63. Compared with the groups with scores ≤62, this group had a good prognosis; we thus considered HRD scores ≥63 to be the best cutoff point for identifying HRD cases in HGSOC. Classification of HGSOC cases by the HRD status revealed a better prognosis for HRD cases caused by genetic alterations (genetic HRD) than those caused by epigenetic changes and those caused by undetermined reasons (p = 0.0002). Among cases without macroscopic residual tumors after primary debulking surgery, 11 of 12 genetic HRD cases survived after the median observation period of 6.6 years, showing remarkably high survival rates (p = 0.0059). In conclusion, HGSOC can be classified into subtypes with different prognoses according to HRD status. This classification could be useful for personalized HGSOC treatment.
Genomic insights into the lifestyles, functional capacities and oleagenicity of members of the fungal family Trichosporonaceae
Authors: Aliyu Habibu , Gorte Olga , de Maayer Pieter , Neumann Anke , Ochsenreither Katrin
Published: February 2020

Trichosporonaceae incorporates six genera of physiologically and ecologically diverse fungi including both human pathogenic taxa as well as yeasts of biotechnological interest, especially those oleagenic taxa that accumulate large amounts of single cell oils (SCOs). Here, we have undertaken comparative genomic analysis of thirty-three members of the family with a view to gain insight into the molecular determinants underlying their lifestyles and niche specializations. Phylogenomic analysis revealed potential misidentification of three strains which could impact subsequent analyses. Evaluation of the predicted proteins coding sequences showed that the free-living members of the family harbour greater numbers of carbohydrate active enzymes (CAZYmes), metallo- and serine peptidases compared to their host-associated counterparts. Phylogenies of selected lipid biosynthetic enzymes encoded in the genomes of the studied strains revealed disparate evolutionary histories for some proteins inconsistent with the core genome phylogeny. However, the documented oleagenic members distinctly cluster based on the constitution of the upstream regulatory regions of genes encoding acetyl-CoA carboxylase (ACC), ATP-citrate synthase (ACS) and isocitrate dehydrogenase [NADP] (ICDH), which are among the major proteins in the lipid biosynthetic pathway of these yeasts, suggesting a possible pattern in the regulation of these genes.
PDCD4 controls the G1/S-phase transition in a telomerase-immortalized epithelial cell line and affects the expression level and translation of multiple mRNAs
Authors: Haas Astrid , Nilges Benedikt S. , Leidel Sebastian A. , Klempnauer Karl-Heinz
Published: February 2020

PDCD4, the protein encoded by the tumor suppressor gene PDCD4 (programmed cell death 4) has been implicated in the control of cellular transcription and translation by modulating the activity of specific transcription factors and suppressing the translation of mRNAs with structured 5′-UTRs. Most studies of human PDCD4 have employed tumor cell lines, possibly resulting in a biased picture of its role in normal cells. Here, we have studied the function of PDCD4 in a telomerase-immortalized human epithelial cell line. We show for the first time that PDCD4 is required for the G1/S-transition, demonstrating its crucial role in the cell cycle. Inhibition of p53-dependent activation of p21WAF1/CIP1 overrides the requirement for PDCD4 for the G1/S-transition, suggesting that PDCD4 counteracts basal p53 activity to prevent activation of the G1/S checkpoint by p53. Transcriptome and ribosome profiling data show that silencing of PDCD4 changes the expression levels and translation of many mRNAs, providing an unbiased view of the cellular processes that are affected by PDCD4 in an epithelial cell line. Our data identify PDCD4 as a key regulator of cell cycle- and DNA-related functions that are inhibited when it is silenced, suggesting that decreased expression of PDCD4 might contribute to tumor development by compromising genomic integrity.
One-pot synthesis of sweetening syrup from lactose
Authors: Cheng Shouyun , Metzger Lloyd E. , Martínez-Monteagudo Sergio I.
Published: February 2020

Lactose has become the main byproduct of many dairy products and ingredients. Current applications of lactose are insufficient to use the recovered lactose from manufacturing operations. Here we exemplified a new process for converting aqueous lactose into a sweeting syrup via one-pot synthesis. The synthesis consisted of two-steps: (1) enzymatic hydrolysis of lactose and (2) catalytic isomerization over MgO/SiO2. The hydrolysis of lactose over β-galactosidase converted 95.77 ± 0.67% of lactose into glucose and galactose. The catalytic isomerization was performed over MgO/SiO2 with different MgO loadings (10–40 wt.%). A battery of tests was conducted to characterize the different catalysts, including surface properties, basicity, and microstructure. The one-pot synthesis, enzymatic hydrolysis and catalytic isomerization over 20%-MgO/SiO2, converted 99.3% of lactose into a sweetening syrup made of glucose (30.48%), galactose (33.51%), fructose (16.92%), D-tagatose (10.54%), and lactulose (3.62%). The outcomes of this research present an opportunity for expanding the utilization of lactose.
Effects of glucose metabolism pathways on nuclear and cytoplasmic maturation of pig oocytes
Authors: Wen Jing , Wang Guo-Liang , Yuan Hong-Jie , Zhang Jie , Xie Hong-Li , Gong Shuai , Han Xiao , Tan Jing-He
Published: February 2020

The developmental competence of IVM porcine oocytes is still low compared with that in their in vivo counterparts. Although many studies reported effects of glucose metabolism (GM) on oocyte nuclear maturation, few reported on cytoplasmic maturation. Previous studies could not differentiate whether GM of cumulus cells (CCs) or that of cumulus-denuded oocytes (DOs) supported oocyte maturation. Furthermore, species differences in oocyte GM are largely unknown. Our aim was to address these issues by using enzyme activity inhibitors, RNAi gene silencing and special media that could support nuclear but not cytoplasmic maturation when GM was inhibited. The results showed that GM in CCs promoted pig oocyte maturation by releasing metabolites from both pentose phosphate pathway and glycolysis. Both pyruvate and lactate were transferred into pig DOs by monocarboxylate transporter and pyruvate was further delivered into mitochondria by mitochondrial pyruvate carrier in both pig DOs and CCs. In both pig DOs and CCs, pyruvate and lactate were utilized through mitochondrial electron transport and LDH-catalyzed oxidation to pyruvate, respectively. Pig and mouse DOs differed in their CC dependency for glucose, pyruvate and lactate utilization. While mouse DOs could not, pig DOs could use the lactate-derived pyruvate.
Actionable Mutation Profiles of Non-Small Cell Lung Cancer patients from Vietnamese population
Authors: Dang Anh-Thu Huynh , Tran Vu-Uyen , Tran Thanh-Truong , Thi Pham Hong-Anh , Le Dinh-Thong , Nguyen Lam , Nguyen Ngoc-Vu , Thi Nguyen Thai-Hoa , Nguyen Chu Van , Le Ha Thu , Thi Nguyen Mai-Lan , Le Vu Thuong , Nguyen Phuc Huu , Vo Binh Thanh , Thi Dao Hong-Thuy , Nguyen Luan Thanh , Van Nguyen Thien-Chi , Bui Quynh-Tram Nguyen , Nguyen Long Hung , Nguyen Nguyen Huu , Thi Nguyen Quynh-Tho , Le Truong Xuan , Do Thanh-Thuy Thi , Dinh Kiet Truong , Do Han Ngoc , Phan Minh-Duy , Nguyen Hoai-Nghia , Tran Le Son , Giang Hoa
Published: February 2020

Comprehensive profiling of actionable mutations in non-small cell lung cancer (NSCLC) is vital to guide targeted therapy, thereby improving the survival rate of patients. Despite the high incidence and mortality rate of NSCLC in Vietnam, the actionable mutation profiles of Vietnamese patients have not been thoroughly examined. Here, we employed massively parallel sequencing to identify alterations in major driver genes (EGFR, KRAS, NRAS, BRAF, ALK and ROS1) in 350 Vietnamese NSCLC patients. We showed that the Vietnamese NSCLC patients exhibited mutations most frequently in EGFR (35.4%) and KRAS (22.6%), followed by ALK (6.6%), ROS1 (3.1%), BRAF (2.3%) and NRAS (0.6%). Interestingly, the cohort of Vietnamese patients with advanced adenocarcinoma had higher prevalence of EGFR mutations than the Caucasian MSK-IMPACT cohort. Compared to the East Asian cohort, it had lower EGFR but higher KRAS mutation prevalence. We found that KRAS mutations were more commonly detected in male patients while EGFR mutations was more frequently found in female. Moreover, younger patients (<61 years) had higher genetic rearrangements in ALK or ROS1. In conclusions, our study revealed mutation profiles of 6 driver genes in the largest cohort of NSCLC patients in Vietnam to date, highlighting significant differences in mutation prevalence to other cohorts.
Molecular characterization of Extended-spectrum β lactamase- producing E. coli recovered from community-acquired urinary tract infections in Upper Egypt
Authors: Hassuna Noha A. , Khairalla Ahmed S. , Farahat Eman M. , Hammad Adel M. , Abdel-Fattah Medhat
Published: February 2020

Treatment of community urinary tract infections (UTIs) caused by extended-spectrum β lactamase (ESBL)- producing Escherichia coli (E. coli) is more expensive than treating ESBL-negative opposites. Evaluation of the prevalence of ESBL-production among urinary E. coli isolates is crucial due to its great impact on the choice of proper antimicrobials. Accordingly, the aim of this work was to detect and characterize ESBL-producing E. coli isolated from outpatients with signs of UTIs in Upper Egypt. Urinary E. coli isolates were identified by 16S rRNA and their ESBL-production was confirmed by Modified Double Disc Synergy Test (MDDST) and ESBL- CHROMagar media. Isolates were then subjected to Polymerase Chain Reaction (PCR) for new Clermont phylogrouping, ESBL genes detection and CTX-M typing. The study enrolled 583 patients with clinically diagnosed UTIs. Uropathogens were found in 400 urine samples (68.6%) out of which 134 E. coli isolates were identified. Among the examined uropathogenic E. coli (UPEC), 80 (59.7%) were recognized as ESBL-producers. Greater than half of the ESBL-producers were multi-drug resistant (MDR) (62%). All of them were susceptible to meropenem. Most of the E. coli isolates were distributed in 4 phylogenetic groups: B2 = 42 (52.5%), F = 17 (21.25%) and Clade I or II = 10 (12.5%). The predominant gene types were TEM 60 (75%) and CTX-M gene 45 (56.25%). The CTX-M-1 group was the most prevalent (62.2%), including the CTX-M-15 enzyme, followed by the CTX-M-2 group, CTX-M-8 group and CTX-M-9 group. In conclusion, the results present alarming evidence of a serious spread of ESBL genes in Egypt, especially the epidemiological CTX-M 15, with the potential for the dissemination of MDR UPEC strains in the community.
Efficacy of red yeast rice extract on myocardial infarction patients with borderline hypercholesterolemia: A meta-analysis of randomized controlled trials
Authors: Sungthong Bunleu , Yoothaekool Chenchira , Promphamorn Sornsalak , Phimarn Wiraphol
Published: February 2020

Red yeast rice (RYR) extract is widely used for improving cardiovascular outcomes and lipid profiles. However, RYR efficacy on cardiovascular outcomes in myocardial infarction (MI) patients remains unclear. This meta-analysis assessed efficacy of RYR extract in MI patients with borderline hypercholesterolemia. PubMed, CENTRAL, CINAHL, Scopus, Web of Science, and Clinicaltrials.gov were systematically searched from inception through May 2019 for relevant publications. Seven studies with 10,699 MI patients diagnosed with borderline hypercholesterolemia were included. Follow-up periods ranged from 4 weeks – 4.5 years and the studies were overall of high quality with low risk of bias. RYR extract (1,200 mg/day) reduced nonfatal MI (risk ratio (RR) = 0.42, 95% CI 0.34 to 0.52), revascularization (RR = 0.58, 95% CI 0.48 to 0.71), and sudden death (RR = 0.71, 95% CI 0.53 to 0.94). RYR extract also lowered LDL (weighted mean difference (WMD) = −20.70 mg/dL, 95% CI −24.51 to −16.90), TC (WMD = −26.61 mg/dL, 95% CI −31.65 to −21.58), TG (WMD = − 24.69 mg/dL, 95% CI −34.36 to −15.03), and increased HDL levels (WMD = 2.71 mg/dL, 95% CI 1.24 to 4.17). This meta-analysis indicated that RYR extract in MI patients with borderline hypercholesterolemia is associated with improved cardiovascular outcomes and lipid profiles.
Publisher Correction: Prediction of malignant glioma grades using contrast-enhanced T1-weighted and T2-weighted magnetic resonance images based on a radiomic analysis
Authors: Nakamoto Takahiro , Takahashi Wataru , Haga Akihiro , Takahashi Satoshi , Kiryu Shigeru , Nawa Kanabu , Ohta Takeshi , Ozaki Sho , Nozawa Yuki , Tanaka Shota , Mukasa Akitake , Nakagawa Keiichi
Published: February 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
A smartphone-based biomedical sensory system
Authors: Zhao Wenhao , Tian Shulin , Huang Lei , Liu Ke , Dong Lijuan , Guo Jinhong
Published: February 2020

Disease diagnostics, food safety monitoring and environmental quality monitoring are the key means to safeguard human health.
Fluorescence turn-off-on for highly selective detection of serum l-cysteine based on AuNCs-AuNPs ensembles
Authors: Li Xiangfei , Qiao Juan , Li Zhiwei , Qi Li
Published: February 2020

The discriminative monitoring of l-cysteine in biological fluids is a great challenge. A fluorescent “turn-off-on” probe based on AuNCs-AuNPs ensembles for l-cysteine detection with high selectivity has been developed.
Biomembrane induced in situ self-assembly of peptide with enhanced antimicrobial activity
Authors: Shen Zhiwei , Guo Zhen , Zhou Limin , Wang Yujiao , Zhang Jinjin , Hu Jun , Zhang Yi
Published: February 2020

FF8 self-assembled into nanofibers on the negatively charged lipid membrane and induced rupture of the membrane.
A bioconjugated MoS2 based nanoplatform with increased binding efficiency to cancer cells
Authors: Kálosi Anna , Labudová Martina , Annušová Adriana , Benkovičová Monika , Bodík Michal , Kollár Jozef , Kotlár Mário , Kasak Peter , Jergel Matej , Pastoreková Silvia , Siffalovic Peter , Majkova Eva
Published: February 2020

Preparation and study of a MoS2 nanosheet based nanoplatform for a cancer detection and treatment system equipped with an antibody–antigen based recognition element.
A cephalosporin–chemiluminescent conjugate increases beta-lactamase detection sensitivity by four orders of magnitude
Authors: Maity Santanu , Wang Xiaojian , Das Subhamoy , He Maomao , Riley Lee W. , Murthy Niren
Published: February 2020

A beta-lactamase chemiluminescent probe, termed CCP, which can for the first time detect beta-lactamase activity via chemiluminescence and 4-orders of magnitude higher than commercial fluorescent probe.
Order–disorder skewness in alpha-synuclein: a key mechanism to recognize membrane curvature
Authors: Caparotta Marcelo , Bustos Diego M. , Masone Diego
Published: February 2020

Currently, membrane curvature is understood as an active mechanism to control cells spatial organization and activity.
Photoreductive dissolution of cerium oxide nanoparticles and their size-dependent absorption properties
Authors: Pettinger Natasha W. , Empey Jennifer M. , Fröbel Sascha , Kohler Bern
Published: February 2020

Changing the size of cerium oxide nanoparticles with UV light provides insights into the absorption properties of this redox-active photocatalyst.
On the in-plane electronic thermal conductivity of biased nanosheet β12-borophene
Authors: Nguyen Hong T. T. , Hoi Bui D. , Vu Tuan V. , Nham Phan V. , Binh Nguyen T. T.
Published: February 2020

In this work, with the aid of a five-band tight-binding Hamiltonian, the Green's function approach and the Kubo–Greenwood formalism, the electronic thermal conductivity of the semiconducting phase of β12-borophene is studied.
Microhydration of verbenone: how the chain of water molecules adapts its structure to the host molecule
Authors: Chrayteh Mhamad , Savoia Annunziata , Huet Thérèse R. , Dréan Pascal
Published: February 2020

The microsolvation of verbenone (C10H14O)·(H2O)n (n = 1, 2, 3) was investigated in a supersonic expansion using a cavity-based Fourier transform microwave spectrometer, in the 2.8–14 GHz frequency range and by computational chemistry.
New insights on the energy transfer mechanisms of Eu-doped CdS quantum dots
Authors: Tan P. M. , Ca N. X. , Hien N. T. , Van H. T. , Do P. V. , Thanh L. D. , Yen V. H. , Tuyen V. P. , Peng Y. , Tho P. T.
Published: February 2020

Eu-doped CdS quantum dots with the Eu dopant concentration in the range of 0.5–10% and zinc blende structure were successfully synthesized by a wet chemical method in the noncoordinating solvent.
Identification of a receiver triplet state in the ultrafast intersystem crossing of carbonylpyrenes
Authors: R. S. Lekshmi , Kurup Gayathri B. , Vennapusa Sivaranjana Reddy
Published: February 2020

The intersystem crossing receiver triplet state lifetime dictates the efficiency of the triplet quantum yield in carbonylpyrenes.
SO2 deactivation mechanism of NO oxidation and regeneration of the LaCoO3 perovskite
Authors: Martinovic Ferenc , Tran Quang Nguyen , Deorsola Fabio Alessandro , Bensaid Samir , Palkovits Regina , Paulus Werner , Bonelli Barbara , Di Renzo Francesco , Pirone Raffaele
Published: February 2020

The deactivation mechanism and methods to cope with the poisoning by SO2 of a LaCoO3 perovskite-based NO oxidation catalyst were investigated.
Metal coordination to bipyridyl carbynes
Authors: Frogley Benjamin J. , Hill Anthony F.
Published: February 2020

A new synthetic approach to hetero-aryl substituted carbyne complexes has allowed the synthesis of bipyridyl functionalised carbynes and bis(carbynes) with three potential sites for metal coordination to either the two pyridyl donors or the WC bond.
Disappearance kinetics of 56 toxic semi-volatile organic compounds under common storage conditions
Authors: Otim Ochan , Rocha Jesus
Published: February 2020

Loss of purified SVOCs in CH2Cl2 occurs at rates much faster than expected.
A dual biomimetic process for the selective aerobic oxidative coupling of primary amines using pyrogallol as a precatalyst. Isolation of the [5 + 2] cycloaddition redox intermediates
Authors: Largeron Martine , Deschamps Patrick , Hammad Karim , Fleury Maurice-Bernard
Published: February 2020

Low-cost pyrogallol precatalyst undergoes an oxidative self-processing step for delivering the active organocatalystin situthrough a dual biomimetic process.
Catalytic transformation of CO2 into C1 chemicals using hydrosilanes as a reducing agent
Authors: Zhang Yu , Zhang Tong , Das Shoubhik
Published: February 2020

This work summarizes the recent reports about the catalytic hydrosilylation of CO2 using different catalysts such as metal catalysts, organocatalysts, and heterogeneous catalysts.
Development of a high-throughput arrayed neural circuitry platform using human induced neurons for drug screening applications
Authors: Fantuzzo Joseph A. , Robles Denise A. , Mirabella Vincent R. , Hart Ronald P. , Pang Zhiping P. , Zahn Jeffrey D.
Published: February 2020

Development and functionality of a 96 well plate-based platform for high-throughput drug screening of compartmentalized neurocircuit models.
Heteroatom engineering of polymeric carbon nitride heterojunctions for boosting photocatalytic reduction of hexavalent uranium
Authors: Yu Fengtao , Yu Zhiwu , Xu Zhenzhen , Xiong Jianbo , Fan Qiangwen , Feng Xuefeng , Tao Yuan , Hua Jianli , Luo Feng
Published: February 2020

Two push–pull conjugated polymers termed PFB and PCB with different donors unit are innovatively applied to fabricate PFB/g-C3N4 and PCB/g-C3N4 heterojunctions for efficient photocatalytic reduction of uranium.
‘Windmill’-shaped LnIII4 (LnIII = Gd and Dy) clusters: magnetocaloric effect and single-molecule-magnet behavior
Authors: Wang Wen-Min , Wang Mei-Jiao , Hao Sha-Sha , Shen Qin-Yu , Wang Mei-Ling , Liu Qiao-Ling , Guan Xiao-Fen , Zhang Xiu-Tang , Wu Zhi-Lei
Published: February 2020

Two ‘windmill’-shaped Ln4 clusters (1 and 2) have been synthesized. The magnetic study reveals that 1 displays a larger cryogenic magnetocaloric effect, while 2 exhibits SMM behavior.
Formulation and evaluation of β-cyclodextrin-mediated inclusion complexes of isoniazid scaffolds: molecular docking and in vitro assessment of antitubercular properties
Authors: Tom Lincy , Nirmal Christy Rosaline , Dusthackeer Azger , Magizhaveni B. , Kurup M. R. P.
Published: February 2020

Inclusion complexes of isoniazid derivatives with β-CD were synthesized and their potent antitubercular properties were studied.
Contributions of natural products to ion channel pharmacology
Authors: Bajaj Saumya , Ong Seow Theng , Chandy K. George
Published: February 2020

Natural products harnessed from the diverse universe of compounds within the bioenvironment are being used to modulate ion channels, a vast super-family of membrane proteins that play critical physiological roles in excitable and non-excitable cells.
Quantitative analysis of time-resolved RHEED during growth of vertical nanowires
Authors: Jakob Julian , Schroth Philipp , Feigl Ludwig , Hauck Daniel , Pietsch Ullrich , Baumbach Tilo
Published: February 2020

In situ RHEED enables a height-resolved determination of the crystal structure of vertical nanowires via self-shadowing and ensemble shadowing.
Unlocking the catalytic activity of an eight-atom gold cluster with a Pd atom
Authors: Xu Jiayu , Xu Shun , Chen Mingyang , Zhu Yan
Published: February 2020

The Pd atom in the Au8Pd serves as a key to unlock the catalytic process of benzyl alcohol oxidation.
Epitaxial synthesis of ultrathin β-In2Se3/MoS2 heterostructures with high visible/near-infrared photoresponse
Authors: Zou Zixing , Li Dong , Liang Junwu , Zhang Xuehong , Liu Huawei , Zhu Chenguang , Yang Xin , Li Lihui , Zheng Biyuan , Sun Xingxia , Zeng Zhouxiaosong , Yi Jiali , Zhuang Xiujuan , Wang Xiao , Pan Anlian
Published: February 2020

Novel β-In2Se3/MoS2 vertically stacked heterostructures were synthesized, and can be further utilized as excellent photodetectors in the visible and near-infrared range.
TiO2 superstructures with oriented nanospaces: a strategy for efficient and selective photocatalysis
Authors: Murakami Yuta , Kamegawa Takashi , Kobori Yasuhiro , Tachikawa Takashi
Published: February 2020

Highly ordered superstructures of semiconductor nanocrystals with controlled size and orientation of nanospaces have been synthesized without the use of a template or a capping reagent.
Catalytic activities of cocaine hydrolases against the most toxic cocaine metabolite norcocaethylene
Authors: Zheng Xirong , Chen Xiabin , Zhang Ting , Zhan Max , Zhan Chang-Guo , Zheng Fang
Published: February 2020

Combined computational, in vitro and in vivo studies have consistently revealed that two cocaine hydrolases engineered from human butyrylcholinesterase can efficiently catalyze the hydrolysis of the most toxic cocaine metabolite norcocaethylene.
A self-healing supramolecular hydrogel with temperature-responsive fluorescence based on an AIE luminogen
Authors: Li Botian , Zhang Yichi , Yan Bo , Xiao Da , Zhou Xue , Dong Junwei , Zhou Qiong
Published: February 2020

A supramolecular hydrogel was synthesized by using tetra(4-(pyridin-4-yl)phenyl)ethylene (TPPE) as AIE luminogen. The gel not only featured self-healing performance, but also exhibited the temperature-responsive fluorescence with thermochromism.
Heating-up synthesis of cesium bismuth bromide perovskite nanocrystals with tailored composition, morphology, and optical properties
Authors: Lee Donguk , Kim MinHye , Woo Ho-Young , Chae Jiyeon , Lee Dawon , Jeon Sanghyun , Oh Soong Ju , Paik Taejong
Published: February 2020

Lead-free cesium bismuth bromide perovskite nanocrystals are synthesized via the heating-up method with tailored morphology and optical properties.
Enhanced breakdown strength and suppressed dielectric loss of polymer nanocomposites with BaTiO3fillers modified by fluoropolymer
Authors: Zhang Jianxin , Ma Jiachen , Zhang Luqing , Zong Chuanyong , Xu Anhou , Zhang Yabin , Geng Bing , Zhang Shuxiang
Published: February 2020

Preparation of high-performance dielectric composite films using PDFMA@BT hybrid nanoparticles as fillers.
Transient cavity dynamics and divergence from the Stokes–Einstein equation in organic aerosol
Authors: Song Young-Chul , Ingram Stephen , Arbon Robert E. , Topping David O. , Glowacki David R. , Reid Jonathan P.
Published: February 2020

The failure of the Stokes–Einstein relation is assessed in aerosol measurements and molecular dynamics simulations.
A comparative assessment framework for sustainable production of fuels and chemicals explicitly accounting for intermittency
Authors: Ganzer Caroline , Mac Dowell Niall
Published: February 2020

Integrated design and scheduling for methanol and ammonia production from air, water and solar energy, analysing the impacts of intermittency.
A high throughput, linear molecular beam epitaxy system for reduced cost manufacturing of GaAs photovoltaic cells: will GaAs ever be inexpensive enough?
Authors: Lee Byungjun , Fan Dejiu , Forrest Stephen R.
Published: February 2020

A high volume linear molecular beam growth system is proposed. Costs of GaAs cells grown by this or other technologies remains ∼10× higher than silicon solar cells.
Suppression of hypersynchronous network activity in cultured cortical neurons using an ultrasoft silicone scaffold
Authors: Sumi Takuma , Yamamoto Hideaki , Hirano-Iwata Ayumi
Published: February 2020

An ultrasoft silicone elastomer as an alternative substrate for neuronal culture is investigated.
Lubricated steady sliding of a rigid sphere on a soft elastic substrate: hydrodynamic friction in the Hertz limit
Authors: Wu Haibin , Moyle Nichole , Jagota Anand , Hui Chung-Yuen
Published: February 2020

Lubricated sliding on soft elastic substrates occurs in a variety of natural and technological settings.
A general method to construct single-atom catalysts supported on N-doped graphene for energy applications
Authors: Liu Linghui , Liu Song , Li Lu , Qi Haifeng , Yang Hongbin , Huang Yanqiang , Wei Zidong , Li Li , Xu Jinming , Liu Bin
Published: February 2020

Single atom catalysts (SACs) with atomically dispersed catalytic sites have shown great promise for energy related chemical reactions.
Porous nanofiber composite membrane with 3D interpenetrating networks towards ultrafast and isotropic proton conduction
Authors: Zhang Yafang , Zhang Xiang , Li Ping , Wu Wenjia , Lin Jianlong , Wang Jingtao , Qu Lingbo , Zhang Haoqin
Published: February 2020

Nanofiber composite membranes with 3D interpenetrating nanopore networks and enriched acid–base pairs exhibit ultrafast and isotropic proton conduction.
How to functionalise metal–organic frameworks to enable guest nanocluster embedment
Authors: King James , Zhang Linda , Doszczeczko Szymon , Sambalova Olga , Luo Hui , Rohman Fadli , Phillips Omotoyosi , Borgschulte Andreas , Hirscher Michael , Addicoat Matthew , Szilágyi Petra Ágota
Published: February 2020

We report on the development and verification of an enhanced computational model capable of robust predictions and yielding a single descriptor to the successful embedding of nanoclusters into the pores of functionalised metal–organic frameworks.
Yolk–shell or yolk-in-shell nanocatalysts? A proof-of-concept study
Authors: Hu Jun , Li Ruyi , Han Jie , Sun Jia , Wang Yang , Yu Lei , Guo Rong
Published: February 2020

A new class of yolk-in-shell nanocatalysts has been developed, which shows incredibly improved catalytic activity and recyclability compared to yolk–shell nanocatalysts.
In situformation of aluminum–silicon–lithium active materials in aluminum matrices for lithium-ion batteries
Authors: Tahmasebi Mohammad Hossein , Kramer Dominik , Geßwein Holger , Zheng Tianye , Leung Kwan-Chee , Lo Benedict Tsz Woon , Mönig Reiner , Boles Steven T.
Published: February 2020

The Al–Si–Li ternary phase formedin situin an aluminium matrix and was reversibly cycled as a monolithic anode material.
A perovskite solar cell textile that works at −40 to 160 °C
Authors: Xu Limin , Fu Xuemei , Liu Fei , Shi Xiang , Zhou Xufeng , Liao Meng , Chen Chuanrui , Xu Fan , Wang Bingjie , Zhang Bo , Peng Huisheng
Published: February 2020

A wearable solar cell textile that works at −40 to 160 °C has been achieved by designing a compact perovskite layer on aligned TiO2 nanotubes to act as a stress buffer layer on fiber electrode surfaces.
Methoxy substituents activated carbazole-based boron dimesityl TADF emitters
Authors: Ganesan Paramaguru , Chen Deng-Gao , Chen Wen-Cheng , Gnanasekaran Premkumar , Lin Jia-An , Huang Chun-Ying , Chen Meng-Chi , Lee Chun-Sing , Chou Pi-Tai , Chi Yun
Published: February 2020

Five N-borylated TADF emitters bearing both boron dimesityl acceptor and methoxy substituted carbazole are presented with electroluminescence ranging from 444 to 468 nm, and with the best maximum external quantum efficiency of 13.3%.
An anthraquinone-imidazole-based colorimetric and fluorescent sensor for the sequential detection of Ag+ and biothiols in living cells
Authors: Zhao Chen , Kong Xiangyu , Shuang Shaomin , Wang Yu , Dong Chuan
Published: February 2020

An anthraquinone-imidazole-based highly selective colorimetric and fluorescent sensor for the sequential detection of Ag+ and biothiols in living cells is reported.
Nanoporous BiVO4 nanoflake array photoanode for efficient photoelectrochemical water splitting
Authors: Wang Jingjing , Liu Canjun , Liu Yang , Chen Shu
Published: February 2020

A high-quality nanoporous BiVO4 nanoflake array photoanode was prepared by using an in situ transformation approach, which exhibited an excellent photoelectrochemical activity.
Facile synthesis of CuS/MXene nanocomposites for efficient photocatalytic hydrogen generation
Authors: Xie Yi , Rahman Md Mushfiqure , Kareem Shefiu , Dong Hao , Qiao Fen , Xiong Wei , Liu Xiaoqing , Li Neng , Zhao Xiujian
Published: February 2020

Deposition of covellite CuS nanocrystals on the multilayered MXene and few-layered MXene by a facile reaction of S2− with Cu2+ precursors to obtain 0D/2D nanocomposites.
Insight into the charge/discharge behaviour of intercalation cathode materials: relation between delivered capacity and applied rate and analysis of multi-particle intercalation mechanisms
Authors: Kalantarian Mohammad Mahdi , Yousefi Mashhour Hatef , Shahroudi Hamideh , Osanloo Nasim , Mustarelli Piercarlo
Published: February 2020

The relationship between capacity-rate, the performance/rate-capability criterion, predicting the (in)active particle fraction, and calculating the optimal cathode mass are some of the achievements herein.
Thermal spin crossover in Fe(ii) and Fe(iii). Accurate spin state energetics at the solid state
Authors: Vela Sergi , Fumanal Maria , Cirera Jordi , Ribas-Arino Jordi
Published: February 2020

Parametrization of PBE+U under the D3 and D3-BJ dispersion corrections to study FeII and FeIII-based Spin Crossover complexes.
Direct observation of chemical origins in crystalline (NixCo1−x)2B oxygen evolution electrocatalysts
Authors: Ma Xinzhi , Zhao Kaixin , Sun Yu , Wang Yue , Yan Feng , Zhang Xitian , Chen Yujin
Published: February 2020

A crystalline bimetal (Ni0.75Co0.25)2B catalyst synthesized by a simple ball-milling method exhibits excellent OER activity, and the special roles of Co and Ni were accurately certified by CV cycling on hydrophobic and hydrophilic electrodes.
Reductant composition influences the coordination of atomically dispersed Rh on anatase TiO2
Authors: Asokan Chithra , Thang Ho Viet , Pacchioni Gianfranco , Christopher Phillip
Published: February 2020

Distinct local environments for atomically dispersed Rh species on anatase TiO2result from reduction treatments under CO and H2.
Improved hydrogen storage properties of MgH2 by nickel@nitrogen-doped carbon spheres
Authors: Wang Yu , Ding Zhenmin , Li Xinjun , Ren Shuqin , Zhou Shuhua , Zhang Hongming , Li Yuan , Han Shumin
Published: February 2020

We report the preparation of an MgH2–Ni@NCS composite and the cycling hydrogen absorption and desorption of the MgH2–Ni@NCS composite with 10 cycles.
The index of ideality of correlation: models of the flash points of ternary mixtures
Authors: Toropova Alla P. , Toropov Andrey A. , Leszczynska Danuta , Leszczynski Jerzy
Published: February 2020

Reliable information related to the flash point of ternary mixtures assists in the rational classification of different ternary mixtures of liquids.
Dramatic luminescence signal from a Co(ii)-based metal–organic compound due to the construction of charge-transfer bands with Al3+ and Fe3+ ions in water: steady-state and time-resolved spectroscopic studies
Authors: Daga Pooja , Majee Prakash , Singha Debal Kanti , Manna Priyanka , Hui Sayani , Ghosh Ananta Kumar , Mahata Partha , Mondal Sudip Kumar
Published: February 2020

A Co(ii)-based metal–organic compound exhibits luminescence turn-on by Al3+ and quenching by Fe3+ due to the formation of charge-transfer complexes/adducts.
The sulfated modification and antioxidative activity of polysaccharides from Potentilla anserine L
Authors: Zhao Baotang , Tao Faqin , Wang Junlong , Zhang Ji
Published: February 2020

The sulfated modification of polysaccharides from Potentilla anserine L (PAPMAE) was studied.
Iron-mediated interaction of alpha synuclein with lipid raft model membranes
Authors: Perissinotto Fabio , Stani Chiaramaria , De Cecco Elena , Vaccari Lisa , Rondelli Valeria , Posocco Paola , Parisse Pietro , Scaini Denis , Legname Giuseppe , Casalis Loredana
Published: February 2020

We demonstrated that pathological conditions as accumulation of iron cations promote fast formation of α-synuclein aggregationin vitro, which preferentially interact with lipid-raft domains in model cell membrane systems.
Local strain-driven migration of oxygen vacancies to apical sites in YBa2Cu3O7−x
Authors: Mundet Bernat , Hartman Steven T. , Guzman Roger , Idrobo Juan C. , Obradors Xavier , Puig Teresa , Mishra Rohan , Gázquez Jaume
Published: February 2020

The relationship between the formation of oxygen vacancies in the apical sites of the YBa2Cu3O7−x structure and the commonly observed Y2Ba4Cu8O16 intergrowth defect has been demonstrated by examination of thin-film and single crystal samples.
Access to C4-arylated benzoxazoles from 2-amidophenol through C–H activation
Authors: Sahoo Kanchanbala , Pradhan Priyanka , Panda Niranjan
Published: February 2020

A Pd-catalyzed aerobic approach to access C4-aryl benzoxazoles by tandem C–H ortho-arylation and acid-mediated annulation of 2-amidophenol has been presented.
Quantification of cooperativity in the self-assembly of H-bonded rosettes
Authors: Motloch Petr , Hunter Christopher A.
Published: February 2020

The effective molarity associated with the macrocyclisation step in the self-assembly of triaminopyrimidines with barbiturates and with cyanates was measured as 2 M.
18F-Labeled dihydromethidine: positron emission tomography radiotracer for imaging of reactive oxygen species in intact brain
Authors: Egami Hiromichi , Nakagawa Satoshi , Katsura Yuki , Kanazawa Masakatsu , Nishiyama Shingo , Sakai Toshihiro , Arano Yasushi , Tsukada Hideo , Inoue Osamu , Todoroki Kenichiro , Hamashima Yoshitaka
Published: February 2020

Dihydromethidine (DHM) labeled with 18F at the para position of the benzene ring has been developed as a positron emission tomography (PET) radiotracer for non-invasive imaging of reactive oxygen species (ROS).
Ruthenium-catalysed cyclisation reactions of 1,11-dien-6-ynes leading to biindenes
Authors: Matsuda Takanori , Yonekubo Naoto
Published: February 2020

1,1′-Biindenes were prepared from 1,2-bis(2-allylphenyl)ethynes via cycloisomerisation and tandem RCM reactions, both of which are catalysed by ruthenium.
Regulation of clusterization-triggered phosphorescence from a non-conjugated amorphous polymer: a platform for colorful afterglow
Authors: Wang Shuaiqi , Wu Duobin , Yang Shuming , Lin Zhenghuan , Ling Qidan
Published: February 2020

Ultralong and colorful clusterization-triggered phosphorescence (CTP) has been realized by changing polymerization conditions of polyacrylamides (PAMs). These materials have huge potential in the application of sensing, anti-counterfeiting and LEDs.
Aggregation-induced emission of a 2D protein supramolecular nanofilm with emergent functions
Authors: Liu Ruirui , Jing Jiangbo , Zhang Song , Wang Ke , Xu Bin , Tian Wenjing , Yang Peng
Published: February 2020

A 2D protein supramolecular nanofilm exhibiting aggregation-induced emission is synthesized at the air/water interface or on a solid surface in several minutes, which could be used in anti-counterfeiting for edible items or living creatures.
MOF derived high-density atomic platinum heterogeneous catalyst for C–H bond activation
Authors: Zhuang Zewen , Wang Yu , Chen Zheng , Wang Dingsheng , Chen Chen , Peng Qing , Li Yadong
Published: February 2020

A MOF-derived hollow nanobox with high-density under-coordinated atomic Pt sites exhibits excellent performance in direct C–H bond borylation.
Few-layer WS2nanosheets with oxygen-incorporated defect-sulphur entrapped by a hierarchical N, S co-doped graphene network towards advanced long-term lithium storage performances
Authors: Wang Yan , Zhao Xiaojun , Liu Zhi-Hong
Published: February 2020

One-step preparation of few-layer oxygen incorporation in defect-sulphur WS2nanosheets embedded into the NSG framework exhibits excellent Li-ion storage properties.
Monte Carlo simulations using PELE to identify a protein–protein inhibitor binding site and pose
Authors: Díaz Lucía , Soler Daniel , Tresadern Gary , Buyck Christophe , Perez-Benito Laura , Saen-Oon Suwipa , Guallar Victor , Soliva Robert
Published: February 2020

PELE prospectively unveils the binding site and mode of a protein–protein disruptor.
Correction: Chemistry critical friendships: investigating chemistry-specific discourse within a domain-general discussion of best practices for inquiry assessments
Authors: Schafer Adam G. L. , Yezierski Ellen J.
Published: February 2020

Correction for ‘Chemistry critical friendships: investigating chemistry-specific discourse within a domain-general discussion of best practices for inquiry assessments’ by Adam G. L. Schafer et al., Chem. Educ. Res. Pract., 2020, 21, 452–468.
The effect of macromolecular structure on the rheology and surface properties of amphiphilic random polystyrene-r-poly(meth)acrylate copolymers prepared by RDRP
Authors: Migliore Nicola , Picchioni Francesco , Raffa Patrizio
Published: February 2020

A systematic study of solution properties and micellization in water of amphiphilic random copolymers is presented for the first time.