bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Butir Soal Tema 3 “Peduli Terhadap Makhluk Hidup” Kelas IV SDN 2 Kertaraharja Tahun Pelajaran 2021/2022
Authors: Fatin Refa Tiwi Alia , Sekarsari Nurdini  , Siti Farkhanah  , Bella Belinda
Published: November 2023

This study aims to determine the feasibility of the question items compiled by researchers for multiple choice tests on theme 3 "Caring for Living Things" grade IV elementary school. The feasibility of the question item in question is in terms of the validity of the question, the reliability of the question, the difficulty index of the question, the differentiability, and distractor effectiveness. This research is a descriptive research that is analyzed by quantitative methods. The subjects are grade IV students of SDN 2 Kertaraharja for the 2021/2022 academic year, totaling 40 students. Data collection technique with multiple choice test amounting to 20 items. The data obtained are analyzed with the help of the SPSS 25.0 program. The results showed that (1) The quality of the material aspects and construction aspects in the grain showed that the overall question item was very good. However, the language aspect still does not meet the criteria for writing indicators (2) The quality of the uji validity shows 90% of the items of the question are valid. (3) The reliability tested has an value r11 more than 0.70 i.e. 0.763 meaning the question of having high reliability; (4) The difficulty rate of 95% of the questions includes medium question criteria, 5% of difficult questions; (5) Thedifferentiator of the questions shows 95% of the questions are good and 5% are not good; (6) Ethe fecundity of the extractor indicates that 100% of the option is declared to have functioned effectively; and (7) Overall the quality of the question items is good but the question items number 16 and 19 are not good items.
Upaya Meningkatkan Hasil Belajar PPKn Materi Keberagaman Sosial, Budaya, dan Ekonomi Masyarakat dengan Menggunakan Metode Mind Mapping pada Siswa Kelas VI B SD Negeri 8 Kota Bengkulu Semester I Tahun Pelajaran 2021/2022
Authors: Zunaida
Published: November 2023

Mind Mapping is a creative, and literally, mind mapping way of note-takig. Mind Mapping requires children to be creative and effective in the process of mind mapping through colors and images as outlined in a mind map. Mind Mapping is one of the learning strategies that seeks a student to explore creative ideas in participating in learning activitees, This study aims to determine the application of the mind mapping method to improve the learning outcomes of Civics on Social, Cultural, and Economic Diversity material for grage VI B SD Negeri 8 Bengkulu City in the academic year 2021/2022. Based on the results of the study, it was shown that the application of the Mind Mapping Method could improve Civics learning outcomes. This is indicated by the increase in student learning out comes at the Pre-cycle I, and Cycle II stages. At the pre-cycle stage of 27 students, data obtained that there were 21 students who scored below the predetermined KKM of 75, and the average grade of the new class reached 65,18. Meanwhile, there are only 6 students who get scores above the KKM. Furthermore, in Cycle I, students who scored above the KKM were 11 people and the grades were below the KKM were 16 people, the average grade was 72,59. In Cycle II of 27 students, data was obtained that there were 6 students who scored below the KKM (22,222), while students who scored above the KKM were 21 students (77,777 %) The average grage was 80.
Analisis Kerja Sama Antara Guru Orang Tua dan Siswa dalam Mengatasi Gejala Kesulitan Belajar Tematik Bermuatan PPKN Saat BDR (Belajar Dari Rumah) di Kelas IV SDN 8 Bengkulu Tengah
Authors: Yunita Fitri , Djuwita Puspa , Muktadir Abdul
Published: November 2023

This study aims to describe the analysis of cooperation between teachers, parents and students in thematic learning difficulties charged with PPKN during BDR (learning from home) in grade IV SDN 8 Bengkulu Tengah. This type of research is qualitative with a descriptive study method. The subjects of the study were teachers, parents and students. Research instruments using observation guidelines, interviews and documentation. Data were analyzed through data collection, data reduction, data display, conclusion drawing/verification. The implementation of the learning is not optimal but has been passionate about the expected BDR learning.
PENERAPAN MODEL PEMBELAJARAN PJBL UNTUK MENINGKATKAN HASIL BELAJAR MAHASISWA PADA PERKULIAHAN PENGEMBANGAN PEMBELAJARAN TEMATIK
Authors: Agusdianita Neza , Kurniawati Ike , Supriatna Irfan , Tarmizi Pebrian
Published: November 2023

Penelitian ini bertujuan untuk mendeskripsikan penerapan model pembelajaran project based learning pada perkuliahan pengembangan pembelajaran tematik di Prodi PGSD FKIP Unib. Mata kuliah ini adalah mata kuliah dengan beban sks teori dan praktik. Mata kuliah ini bertujuan untuk menghasilkan mahasiswa yang mampu merencanakan pembelajaran tematik, melaksanakan simulasi mengajar dan mengevaluasi pembelajaran. Luaran dari mata kuliah ini adalah perangkat pembelajaran dan video pelaksanaan simulasi pembelajaran. Penelitian ini menggunakan metode penelitian tindakan (Action Research). Prosedur penelitian tindakan kelas yaitu : (1) perencanaan, (2) pelaksanaan, (3) pengamatan, dan (4) refleksi. Instrumen penelitian berupa lembar obervasi dan lembar penilaian perangkat pembelajaran dan video pembelajaran. Data dianalisis secara deskriptif kualitatif. Instrumen penelitian adalah Peneliti dilengkapi dengan RPS mata kuliah dan Lembar tes kemampuan pemahaman. Teknik analsisis data secara deskriptif kualitatif. Luaran penelitian ini adalah publikasi pada jurnal nasional terakreditasi sinta 4 Jurnal PGSD Universitas Bengkulu
PENGARUH PENGGUNAAN DAUN PANDAN DAN DAUN PISANG PADA PEMBUATAN TAPE KETAN
Authors:   Universitas Islam Negeri Raden Fatah Sumatera Selatan, Indonesia, Safitri Renita Dwi , Purnama Sri Widari ,   Universitas Islam Negeri Raden Fatah Sumatera Selatan, Indonesia, Ramadhani Nabila ,   Universitas Islam Negeri Raden Fatah Sumatera Selatan, Indonesia, Saffana Nur ,   Universitas Islam Negeri Raden Fatah Sumatera Selatan, Indonesia, Habisukan Ummi Hiras ,   Universitas Islam Negeri Raden Fatah Sumatera Selatan, Indonesia
Published: November 2023

Sejak jaman dahulu, Tape merupakan salah satu makanan tradisional yang cukup terkenal di Indonesia. Biasanya makanan ini terbuat dari bahan beras ketan maupun ubi. Ketan dan ubi ini dipilih sebagai bahan dasar dalam pembuatan tape karena ketan dan ubi merupakan bahan yang mengandung karbohidrat tinggi. Beras ketan yang difermentasi juga dapat membuat usus menjadi sehat serta mencegah penyakit gastrointestinal seperti kolitis ulserativa yang menular, tukak duodenum, sindrom iritasi usus, penyakit Crohn, penyakit celiac, infeksi candida, dan lain-lain. Bahan yang digunakan dalam penelitian ini adalah ketan, daun pandan, ragi, air, dan daun pisang. Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan daun pandan dan daun pisang dalam pembuatan tape ketan. Penelitian ini menggunakan metode studi uji eksperimen dari fermentasi tape ketan daun pandan yang di bungkus dengan daun pisang. Dilakukan di salah satu rumah pribadi dari peneliti pada tanggal 2 Juni 2023. Hasil penelitian menunjukkan bahwa pembuatan tape ketan menggunakan daun pandan dan daun pisang menghasilkan tape yang memiliki aroma, cita rasa, warna serta masa simpan yang lebih lama.
“THE DAY OF WRATH” BY YURII KOSACH: MODERNIZATION OF THE HISTORICAL NOVEL
Authors: Василенко Вадим
Published: November 2023

The novel “The Day of Wrath” by Yurii Kosach is a modernist literary experiment, which reflected genre and stylistic searches of the late 1940s and the features of the individual creative and ideological evolution of the writer. The novel by Kosach attempts to question Polish and Russian imperial views on the events and the era of the Ukrainian Cossack Revolution, as well as to discard established social and religious concepts in favor of a national-cultural one.

The novelty of Kosach’s literary technique in the novel lies, in particular, in the method of kaleidoscopic arrangement of material chosen by the author, the specific alternation of images and situations, the incorporation of cinematographic elements, and the utilization of the ‘stream of consciousness’ technique. There are elements of baroque, romantic, and expressionist poetics in the structure of Kosach’s novel, and it’s the syncretism of these stylistic trends that underlies the uniqueness of Kosach’s author’s style. His works are marked with ornamentality, complicated associativity, the motif of duality, and the special function of the metaphor. These features bring Kosach’s writings closer to baroque poetics. Kosach’s “Day of Wrath” is also connected with the tradition of the romantic historical novel through the use of typical romantic images, schemes, and situations, which the author attempts to modernize. The expressionistic stylistic tendencies are evident in “The Day of Wrath” at the linguistic level, characterized by fragmentary writing, elliptical sentences, and a deliberate violation of syntax. These tendencies also manifest themselves in the means and techniques used for image and form creation. The paper highlights the characteristics of Kosach’s ideological and literary interpretation of Bohdan Khmelnytskyi’s image. The hetman is portrayed as a historical figure, a "baroque man," and a statesman-demiurge. Yurii Kosach created a sample of the historical novel, resonating with his time and his own historical and literary views. In order to fulfil this task, he updated its content and form, making some changes in genre and narrative canons.
Robustness of Energy Landscape Controllers to Dephasing
Authors: O'Neil Sean , Schirmer Sophie , Langbein Frank
Published: November 2023

As shown in previous work, in some cases closed quantum systems exhibit a non-conventional absence of trade-off between performance and robustness in the sense that controllers with the highest fidelity can also provide the best robustness to parameter uncertainty. As the dephasing induced by the interaction of the system with the environment guides the evolution to a more classically mixed state, it is worth investigating what effect the introduction of dephasing has on the relationship between performance and robustness. In this paper we analyze the robustness of the fidelity error, as measured by the logarithmic sensitivity function, to dephasing processes. We show that introduction of dephasing as a perturbation to the nominal unitary dynamics requires a modification of the log-sensitivity formulation used to measure robustness about an uncertain parameter with non-zero nominal value used in previous work. We consider controllers optimized for a number of target objectives ranging from fidelity under coherent evolution to fidelity under dephasing dynamics to determine the extent to which optimizing for a specific regime has desirable effects in terms of robustness. Our analysis is based on two independent computations of the log-sensitivity: a statistical Monte Carlo approach and an analytic calculation. We show that despite the different log-sensitivity calculations employed in this study, both demonstrate that the log-sensitivity of the fidelity error to dephasing results in a conventional trade-off between performance and robustness.
Understanding the Background of Personality Disorders and the Influence of Early Experiences with Parents to their View of God
Authors: Pranata Lanny
Published: November 2023

Early relationship is very significant in developing a healthy personality. What a child experience during first three years of life can have a lifelong impact. Early relationships not only act as a template of the brain, but also mold and shape the child’s ability for future relationships with others. Early relationship also becomes the determinant of normal or pathological splitting. Splitting is universal and not all splitting cause a pathology. Maternal-availability is essential during first three years of life. Normal splitting can happen when good-enough mother on some occasion is unavailable or unable to attend to the infant and meet his needs. The child can tolerate the good-enough mother’s unavailability at certain times because he or she is in ‘holding environment’ that makes the child feel secure, protected, and not excessively frustrated. Pathological splitting can happen when the infant receives excessively unsatisfying, frustrating and abusive experience. Severe splitting makes one to see everything in terms of black and white. He or she is not able to accept bad and good at the same time or cannot accept paradoxical qualities in others. A normal person can accept this paradoxical quality, but a personality disorder person cannot accept this paradoxical quality.  Finally, early relationships influence one’s relationship to God, how he or she sees God and experience God. Three studies have found that early relationship with parents, whether secure or insecure relationships can influence how one sees God and relates to God (Gravitt, 2011; Pehr Granqvist, 2007; Rosalinda Cassibba, 2013). One who has a secure attachment with his or her parent, tend to trust God and has a secure relationship with God as well. As a therapist, it is essential that we provide a secure base for our patients or clients. Psychodynamic therapy is the kind of therapy that proved to help patients with Personality Disorders. Successful treatment should not only relieve symptoms but also make intrapsychic change by providing patients with a relationship that enables them to resolve the splitting of their ego.
E670G PCSK9 polymorphism in HeFH & CAD with diabetes: is the bridge to personalized therapy within reach?
Authors: Alieva Rano , Shek Aleksandr , Abdullaev Alisher , Fozilov Khurshid , Khoshimov Shovkat , Abdullaeva Guzal , Zakirova Dariya , Kurbanova Rano , Kan Lilia , Kim Andrey
Published: November 2023

Objective

To assess the distribution of PCSK9 E670G genetic polymorphism and PCSK9 levels in patients with Coronary Artery Disease (CAD) and Heterozygous Familial Hypercholesterolemia (HeFH), based on the presence of type 2 Diabetes Mellitus (T2DM).

Methods

The study included 201 patients with chronic CAD, including those with HeFH (n=57, group I) and without it (n=144, group II). DLCN was used to diagnose HeFH. The PCSK9 E670G (rs505151) polymorphism was genetically typed using the PCR-RFLP procedure. In both the patient and control groups, the genotype frequency matched the Hardy-Weinberg equilibrium distribution (P>0.05).

Results

There were twice more G alleles in group I (13, 11.4%) than in group II (17, 6.0%), and thrice more (1, 3.0%) than in the healthy control group; nevertheless, these differences weren’t statistically significant. Simultaneously, PCSK9 levels were higher in HeFH patients (P<0.05) compared to non-HeFH patients not taking statins (n=63). T2DM was equally represented in groups I and II (31.6% vs. 33.3%). But carriers of AG+GG genotypes in group I had a higher chance of having a history of T2DM (RR 4.18; 95%CI 2.19-8.0; P<0.001), myocardial infarction (RR 1.79; 95%CI 1.18-2.73; P<0.05), and revascularization (RR 12.6; 95%CI 4.06-38.8; P<0.01), than AA carriers. T2DM was also more common among G allele carriers (RR 1.85; 95% CI 1.11-3.06; P<0.05) in patients with non-HeFH.

Conclusion

T2DM in patients with CAD, both with HeFH and non-HeFH, in the Uzbek population was significantly more often associated with the presence of the “gain-of-function” G allele of the PCSK9 E670G genetic polymorphism.
Towards net-zero: CO2 capture and biogas purification through electric potential swing desorption to achieve SDGs 7 and 13
Authors: Farooq Muhammad , Rehman Ateekh Ur , Anwer Izza , Imran Muhammad , Pettinau Alberto , Andresen John M.
Published: November 2023

Currently, the potential of biomethane derived from biogas is substantial, positioning it to fulfill a considerable share of the United Kingdom’s total energy needs. The primary challenge associated with raw biogas lies in purifying it to produce biomethane, a process that necessitates the removal of carbon dioxide and hydrogen sulfide. Among the various methods, adsorption of activated carbon (AC) stands out as a particularly effective and cost-efficient approach for converting biogas into biomethane, provided that the regeneration of AC proves economically viable. In this research, a segment of activated carbon was utilized to assess the adsorption properties when exposed to a gas mixture of CO2, H2S, and N2 within a regenerative activated carbon setup. This investigation encompassed the analysis of adsorption and desorption behaviors, process capacities, and the impact of regeneration. To enhance the adsorption of CO2, electro-conductive polymers (ECPs) were incorporated into the AC samples, leading to an extension in breakthrough time. Subsequent to adsorption, the electric potential swing desorption (EPSD) was employed for in situ regeneration of activated carbon samples, involving potentials of up to 30 V. The findings exhibited that the newly introduced EPSD technique considerably diminished desorption durations for both H2S and CO2. Moreover, it successfully rejuvenated the accessible adsorption sites, resulting in reduced desorption times compared to the initial breakthrough time during adsorption. Consequently, the EPSD system proves to be a promising candidate for in situ regeneration of activated carbon to eliminate CO2 and H2S from biogas. Notably, this approach offers inherent advantages over conventional methods including thermal swing adsorption (TSA) and pressure swing adsorption (PSA) in terms of regeneration. The demonstrated method underscores the potential for more efficient and economically viable cycles of adsorption and desorption, thereby enhancing the overall biogas-to-biomethane conversion process to achieve SDGs 7 and 13 for clean and green energy applications.
Molecular genetics of neuropsychiatric illness: some musings
Authors: Janardhanan Meghana , Sen Somdatta , Shankarappa Bhagylakshmi , Purushottam Meera
Published: November 2023

Research into the genetic underpinnings of neuropsychiatric illness has occurred at many levels. As more information accumulates, it appears that many approaches may each offer their unique perspective. The search for low penetrance and common variants, that may mediate risk, has necessitated the formation of many international consortia, to pool resources, and achieve the large sample sizes needed to discover these variants. There has been the parallel development of statistical methods to analyse large datasets and present summary statistics which allows data comparison across studies. Even so, the results of studies on well-characterised clinical datasets of modest sizes can be enlightening and provide important clues to understanding these complex disorders. We describe the use of common variants, at multiallelic loci like TOMM40 and APOE to study dementia, weighted genetic risk scores for alcohol-induced liver cirrhosis and whole exome sequencing to identify rare variants in genes like PLA2G6 in familial psychoses and schizophrenia in our Indian population.
Relationship between driver gene mutations and clinical pathological characteristics in older lung adenocarcinoma
Authors: Liu Xia , Jiang Guopeng , Sun Xuefei , Su Guangfeng , Zhang Xuan , Shen Dan , Yan Na
Published: November 2023

Objectives

Lung adenocarcinoma (LUAD) is the most common newly diagnosed malignant tumor in older people. As older patients age, organ function decreases, leading to increased adverse reactions to treatment. The epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase tyrosine (ALK) tyrosine kinase inhibitors (TKIs) therapy are more effective and well-tolerated than chemotherapy, while the rate of genetic testing and subsequent targeted treatment among older patients remains relatively low, the clinical benefit limitation for those patients. This study aims to investigate the mutation characteristics of LUAD diver gene and its relationship with clinicopathological features in older LUAD.

Materials and methods

A total of 275 patients were diagnosed as LUAD and were over sixty years old. We utilized next-generation sequencing technology to detect and analyze gene mutations in postoperative tissue specimens, including EGFR, KRAS, ALK, ROS1, RET, MET, BRAF, HER2, PIK3CA and NRAS.

Results

A total of 90.18% (248/275) of older LUAD patients experienced genetic mutations. The EGFR (192, 69.82%) had the highest mutation rate among ten genes, followed by KRAS (21, 7.64%), MET (21, 7.64%), ERBB2 (15, 5.45%), RET (9, 3.27%), ALK (8, 2.91%), ROS1 (8, 2.91%), PIK3CA (6, 2.18%), BRAF (5, 1.82%) and NRAS (1, 0.36%). We also found thirty patients (15.63%) with EGFR mutations also having other gene mutations. The L858R mutation and exon19 deletion were the predominant EGFR mutations, accounting for 84.90% of EGFR-mutated patients. In addition, fifty-one kinds of EGFR mutations were detected, distributed in the protein tyrosine kinase catalytic domain (43, 84.31%), cysteine enriched domain (4, 7.84%), receptor binding domain (3, 5.88%), and EGFR transmembrane domain (1,1.96%). Ten cases of gene fusion mutation were detected. Two rare partner genes, PKHD1 (P60:R34) and STK39 (R33:S11), were detected by ROS1 gene fusion. RET gene fusion revealed a rare companion gene KCND2 (R11:K2). The EGFR mutations were more prevalent in female, non-smoking patients (p < 0.05), and the KRAS mutations were more common in male and smoking patients (p < 0.01). In addition, the BRAF mutations were more likely to occur in the right lung (p < 0.05).

Conclusion

Older LUAD populations exhibit diverse genetic mutations, which may also exist simultaneously. Simultaneous detection of multiple genes by NGS can accelerate and enhance targeted treatment benefits for older LUAD patients, ultimately improving their quality of life.
Development and clinimetric assessment of a performance-based functional vision tool in visually impaired children
Authors: Ghasemi Fard Fatemeh , Mirzaei Hooshang , Hosseini Seyed Ali , Riazi Abbas , Ebadi Abbas , Hooshmandzadeh Narges
Published: November 2023

Objective

Appropriate functional vision is vital for the development of visually impaired (VI) children. However, the literature currently lacks a performance-based tool for assessing functional vision, unlike the existing self-reported tools. The objective of this study is to develop and conduct a clinimetric study on a Performance-Based Functional Vision Tool (PB-FVT) specifically designed for VI children aged 3–7 and 7–10 years old.

Methods

This methodological study was conducted to assess the clinimetric properties of the PB-FVT. The assessment included face validity (evaluated through cognitive interviews and an Impact Score >1.5), content validity (with criteria including content validity ratio >0.63, item content validity index >0.78, scale content validity index or average >0.8, and Kappa value >0.7), criterion validity (assessed through a concurrent test using visual acuity scores), construct validity (utilizing the known group method), relative reliability (measured by the intra-class correlation coefficient), absolute reliability (determined by the standard error of measurement and minimal detectable changes), interpretability, responsiveness, sensitivity, and specificity (analyzed via ROC curve analysis).

Results

The PB-FVT was developed with 32 items, divided into five components: activities of daily living, instrumental activities of daily living, education, play, and social interaction. The results indicate that the scale demonstrates suitability in terms of validity, reliability, and other measurement characteristics.

Conclusions

The valid and reliable PB-FVT may accurately assess the level of functional vision during early childhood, helping to prevent negative impacts on a child's overall development. By utilizing the PB-FVT, any functional vision impairments can be identified appropriately, enabling the planning and implementation of effective rehabilitation interventions.
Phonological discrimination and contrast detection in pupillometry
Authors: Chiossi Julia S. C. , Patou François , Ng Elaine Hoi Ning , Faulkner Kathleen F. , Lyxell Björn
Published: November 2023

Introduction

The perception of phonemes is guided by both low-level acoustic cues and high-level linguistic context. However, differentiating between these two types of processing can be challenging. In this study, we explore the utility of pupillometry as a tool to investigate both low- and high-level processing of phonological stimuli, with a particular focus on its ability to capture novelty detection and cognitive processing during speech perception.

Methods

Pupillometric traces were recorded from a sample of 22 Danish-speaking adults, with self-reported normal hearing, while performing two phonological-contrast perception tasks: a nonword discrimination task, which included minimal-pair combinations specific to the Danish language, and a nonword detection task involving the detection of phonologically modified words within sentences. The study explored the perception of contrasts in both unprocessed speech and degraded speech input, processed with a vocoder.

Results

No difference in peak pupil dilation was observed when the contrast occurred between two isolated nonwords in the nonword discrimination task. For unprocessed speech, higher peak pupil dilations were measured when phonologically modified words were detected within a sentence compared to sentences without the nonwords. For vocoded speech, higher peak pupil dilation was observed for sentence stimuli, but not for the isolated nonwords, although performance decreased similarly for both tasks.

Conclusion

Our findings demonstrate the complexity of pupil dynamics in the presence of acoustic and phonological manipulation. Pupil responses seemed to reflect higher-level cognitive and lexical processing related to phonological perception rather than low-level perception of acoustic cues. However, the incorporation of multiple talkers in the stimuli, coupled with the relatively low task complexity, may have affected the pupil dilation.
Addressing Actuator Saturation during Fault Compensation in Model-Based Underwater Vehicle Control
Authors: Macatangay Xan , Hoseinnezhad Reza , Fowler Anthony , Kayastha Sharmila , Bab-Hadiashar Alireza
Published: November 2023

Robust control systems are a necessity for autonomous underwater vehicle (AUV) systems due to the challenges they face during operation. Many AUV control-design methods have been developed for different actuator configurations, with robustness against model parameter uncertainties, environmental disturbances, and system faults. Actuator faults can reduce the physical capabilities of a system, which can be compensated for through control re-allocation. However, the increased control allocation to the remaining actuators may cause actuator saturation and reduce controller performance. In this work, we present a depth-pitch model-based nonlinear control law that directly considers actuator saturation, and a fault-tolerant control allocation method for a hybrid AUV actuator configuration. Two types of actuator faults are considered for an underwater vehicle with a hybrid actuator configuration. The proposed controller is implemented in a simulated system, and its trajectory tracking performance is compared with a baseline system without fault or saturation tolerance. To determine the utility of the proposed saturation and fault tolerance control methods, the tracking performance in these simulations is quantified in terms of the settling time, post-fault peak values, and root mean square of the depth and pitch errors.
Gallium-Doped Hydroxyapatite: Shape Transformation and Osteogenesis Activity
Authors: Shuai Wei , Zhou Jianguo , Xia Chen , Huang Sirui , Yang Jie , Liu Lin , Yang Hui
Published: November 2023

In this study, we employed a chemical precipitation method to successfully synthesize nanoparticles of gallium-doped hydroxyapatite (Ga-HAp). The microstructure of Ga-HAp was precisely tailored by modulating the concentration of gallium ions. Our findings unequivocally demonstrate that gallium ions exert a pronounced inhibitory influence on the growth of HAp crystals, and this inhibitory potency exhibits a direct correlation with the concentration of gallium. Furthermore, gallium ions facilitate the metamorphosis of HAp nanoparticles, transitioning them from nanoneedles to nanosheets. It is worth noting, however, that gallium ions exhibit a limited capacity to substitute for calcium ions within the crystal lattice of HAp, with the maximum substitution rate capped at 4.85%. Additionally, gallium plays a pivotal role in constraining the release of ions from HAp, and this behavior remains consistent across samples with varying Ga doping concentrations. Our in vitro experiments confirm that Ga-doped HAp amplifies both the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells.
Integration of Deep Learning and Sequential Metabolism to Rapidly Screen Dipeptidyl Peptidase (DPP)-IV Inhibitors from Gardenia jasminoides Ellis
Authors: Liu Huining , Yu Shuang , Li Xueyan , Wang Xinyu , Qi Dongying , Pan Fulu , Chai Xiaoyu , Wang Qianqian , Pan Yanli , Zhang Lei , Liu Yang
Published: November 2023

Traditional Chinese medicine (TCM) possesses unique advantages in the management of blood glucose and lipids. However, there is still a significant gap in the exploration of its pharmacologically active components. Integrated strategies encompassing deep-learning prediction models and active validation based on absorbable ingredients can greatly improve the identification rate and screening efficiency in TCM. In this study, the affinity prediction of 11,549 compounds from the traditional Chinese medicine system’s pharmacology database (TCMSP) with dipeptidyl peptidase-IV (DPP-IV) based on a deep-learning model was firstly conducted. With the results, Gardenia jasminoides Ellis (GJE), a food medicine with homologous properties, was selected as a model drug. The absorbed components of GJE were subsequently identified through in vivo intestinal perfusion and oral administration. As a result, a total of 38 prototypical absorbed components of GJE were identified. These components were analyzed to determine their absorption patterns after intestinal, hepatic, and systemic metabolism. Virtual docking and DPP-IV enzyme activity experiments were further conducted to validate the inhibitory effects and potential binding sites of the common constituents of deep learning and sequential metabolism. The results showed a significant DPP-IV inhibitory activity (IC50 53 ± 0.63 μg/mL) of the iridoid glycosides’ potent fractions, which is a novel finding. Genipin 1-gentiobioside was screened as a promising new DPP-IV inhibitor in GJE. These findings highlight the potential of this innovative approach for the rapid screening of active ingredients in TCM and provide insights into the molecular mechanisms underlying the anti-diabetic activity of GJE.
Influence of Post-Harvest Processing on Functional Properties of Coffee (Coffea arabica L.)
Authors: Halagarda Michał , Obrok Paweł
Published: November 2023

Coffee is one of the most popular beverages worldwide, valued for its sensory properties as well as for its psychoactive effects that are associated with caffeine content. Nevertheless, coffee also contains antioxidant substances. Therefore, it can be considered a functional beverage. The aim of this study is to evaluate the influence of four selected post-harvest coffee fruit treatments (natural, full washed, washed–extended fermentation, and anaerobic) on the antioxidant and psychoactive properties of Arabica coffee. Additionally, the impact of coffee processing on the selected quality parameters was checked. For this purpose, results for caffeine content, total phenolic content (TPC), DPPH assay, pH, titratable acidity, and water content were determined. The results show that natural and anaerobic processing allow the highest caffeine concentration to be retained. The selection of the processing method does not have a significant influence on the TPC or antiradical activity of coffee. The identified differences concerning water content and pH along with lack of significant discrepancies in titratable acidity may have an influence on the sensory profile of coffee.
Stacked Chip-Based Terahertz Metamaterials and Their Application
Authors: Wang Han , Wang Zhigang , Yan Bo , Li Xinyu , Zhang Chenrui , Jiang Huiqi , Deng Minghui , Yin Lesiqi , Gong Cheng
Published: November 2023

A terahertz (THz) metamaterial design mechanism based on a stacked chip is proposed. Unlike the traditional sandwich-type metamaterial design mechanism based on the “resonant layer–dielectric layer–ground layer” structure, it adopts a stacked design of upper and lower metamaterial chips to achieve a new structure based on the “dielectric layer–resonant layer–air layer–ground layer” structure. This could break through the thickness limitations and construct an ultra-thin metamaterial upper chip. To verify the effectiveness of this method, we applied it to the field of THz perfect absorbers. We designed, simulated, and prepared a terahertz stacked chip-based perfect absorber with an upper-chip thickness less than 1/800 of the wavelength. Then, a reflective spectroscopy system based on a vector network analyzer is built to test the absorption performance. The measured results show that it has an absorptivity of 98.4% at 0.222 THz, which is in good agreement with simulations.
Statistical Analysis and Evaluation of Claims Using Control Charts in Certification Bodies
Authors:   Russian State Agrarian University — Moscow Timiryazev Agricultural, Moscow, Russia, Ariskin M.R.
Published: November 2023

The article discusses the basic principles of using control charts in relation to the process of analyzing claims from consumers, namely the types of control charts, their main characteristics, and issues of their practical application. The scientific novelty of the conducted research lies in identifying the main aspects of the use of the control chart methodology in the assessment and analysis of claims received from consumers by the certification body. The purpose of the study is to assess the causes of variability affecting the number of claims received from consumers by the certification body. To achieve this goal, the following tasks were solved: types of control charts were selected, taking into account the specifics of the collected statistical information on types of claims and types of services; the basic principles of using control charts to the claims analysis process have been adapted; control charts were constructed and an analysis of the causes of variability was carried out using the example of a certification body. Based on the conducted research, claims were identified whose occurrence is influenced by special reasons; for the remaining reasons, it was established that their variability is due to ordinary reasons. To determine the most significant factors influencing the special causes of claims, it is recommended to apply the Ishikawa diagram, and then develop measures aimed at reducing the influence of these factors. The data and recommendations obtained by the author as a result of the study can be used by various enterprises and organizations to analyze claims within the framework of the quality management system. The proposed approach will make it possible to make informed management decisions and increase customer satisfaction.
Features and trends in the development of the lean production system
Authors:   Federal State Budgetary Educational Institution of Higher Education Russian State Agrarian University — Moscow Agricultural Academy named after K.A. Timiryazeva, Russia, Moscow, Semukhina E.S.
Published: November 2023

The article discusses the features and trends in the development of the lean production system. The introduction of lean manufacturing elements allows companies to produce high-quality products in the shortest possible time and at minimal cost. This is the main criterion that consumers take into account when choosing goods and services. The benefits of lean manufacturing are obvious: improving product quality, reducing production time, reducing costs and increasing the company's competitiveness. In addition, lean manufacturing helps reduce the negative impact on the environment, which is becoming an increasingly important aspect for consumers these days. Implementing the lean manufacturing concept requires a conscious and strategic approach on the part of company management. It is necessary to analyze current processes, identify potential losses and develop plans to eliminate them. It is also important to train employees in new ways of working and create a suitable culture where continuous improvement and elimination of waste become common practice. The introduction and maintenance of lean manufacturing elements allows us to produce products that are in demand among stakeholders, which helps the company achieve a leading position in the market. Overall, lean manufacturing is an integral part of modern business. Companies that successfully implement its principles gain significant advantages over their competitors. Therefore, in order to achieve a leading position in the market, you need to seriously consider introducing lean manufacturing in your company and follow modern development trends.
Turismo e sustentabilidade: os equipamentos de hospedagem em Trindade, Paraty (RJ)
Authors: Manes Lucas Martins , Lopes Júnior Wilson Martins
Published: November 2023

A procura por destinos turísticos mais próximos à natureza e ambientes naturais indica uma nova dinâmica à prática do turismo. No entanto, essa tendência recente da “busca pelo verde” pode se refletir em impactos socioambientais negativos. Além disso, os equipamentos de hospedagem também são responsáveis por causar esses impactos, uma vez que eles próprios são potencialmente poluidores. Nesse sentido, a Vila de Trindade, área de estudo da presente pesquisa, localizada no município de Paraty (RJ), é um caso relevante para esta discussão, pois é um local com rica biodiversidade natural, e assiste impactos negativos ao meio ambiente por consequência da atividade turística. Dessa forma, o objetivo desta pesquisa foi analisar as pousadas sobre a ótica do seu posicionamento e ações diante das questões socioambientais em Trindade. Importa-nos identificar a posição dos gestores frente à questão socioambiental, assim como as ações sustentáveis que esses equipamentos de hospedagem praticam. Os métodos quantitativo e qualitativo foram empregados para auxiliar na investigação da problemática, com a finalidade de extrair algumas conclusões com base na pesquisa bibliográfica e nas análises dos resultados obtidos através da presença em campo. Foi possível concluir que os equipamentos de hospedagem causam diversos impactos socioambientais negativos para a natureza e para a comunidade local da Vila de Trindade. Percebeu-se também a urgência de desenvolver um planejamento turístico eficaz para esse lugar, com a finalidade de mitigar os danos causados pela atividade turística.
Atividade do gene LRRK2 na Doença de Parkinson: uma revisão de literatura
Authors: Silva de Oliveira Rita de Cássia , De Nazaré Tavares Cardoso Souza Isabela , Dos Santos Souza Murilo , Rodrigues Nunes de Souza Pablo
Published: November 2023

Introdução. A doença de Parkinson (DP) é um distúrbio neurodegenerativo com alta prevalência entre idosos, sua principal causa corresponde à degeneração dos neurônios dopaminérgicos da substância negra pelo acúmulo de alfa-sinucleína intracelular, comprometendo a via nigroestriatal. A DP se relaciona à intensificação da atividade das quinases, promovida pelo gene Leucine-Rich Repeat Kinase 2 (LRRK2), o que acarreta a agregação e a dispersão da toxicidade da alfa-sinucleína. Método. Revisão narrativa de literatura, na qual foram ponderados artigos nas bases de dados PubMed, Literatura Latino-Americana em Ciências da Saúde (LILACS) e Scientific Eletronic Library Online (SCIELO), utilizando-se descritores e operadores booleanos ordenados da seguinte forma: "(alpha-synuclein protein) AND (LRRK2 gene) AND (parkinson's disease)". Resultados. O gene LRRK2 está envolvido em diversas vias celulares que, uma vez mutadas, podem maximizar as chances de desenvolvimento da DP esporádica e familiar. Conforme estudos in vitro e in vivo, as distintas mutações do gene LRRK2 estão relacionadas com a intensificação no acúmulo de alfa-sinucleína, o aumento de sua toxicidade intraneuronal e o desequilíbrio da homeostase proteica. Conclusão. Mutações nos domínios das quinases e da GTPase da proteína podem ocasionar o aparecimento da DP. Apesar de ser um consenso o papel do gene LRRK2 no desenvolvimento do distúrbio neurodegenerativo, os processos pelos quais isso ocorre ainda não estão completamente esclarecidos.
Des stages pour les ouvriers immigrés du bâtiment trois organismes collaborent à une definition de la formation
Authors: Auger Anne-marie
Published: November 2023

À la suite de la publication de la circulaire du 21 mai 1975, le GFC-BTP (Groupement Formation Continue-Bâtiment Travaux Publics ) a financé, par l'intermédiaire de ses antennes régionales, AREF, un certain nombre de stages, en continu, pris sur le temps de travail, pour les travailleurs immigrés.

Nous présentons deux formules de stages AREF, expérimentés en 1975-76 : l'une de formation très ouverte, mise sur pied, à Toulouse, par trois organismes, travaillant en collaboration étroite sur le terrain ; l'autre, liée à l'Education Nationale, et tournée surtout vers un approfondissement des activités professionnelles.
Expériences d'utilisation de la bande dessinée dans des cours de travailleurs migrants
Authors: Demart Maurice , Gonfalone Rémy , Plumet Sylvie , Rivière Henri
Published: November 2023

Cet article ne prétend pas se situer au plan d'une étude exhaustive sur l'utilisation pédagogique de la bande dessinée. Il veut simplement rapporter deux expériences – ou plutôt deux types d' expérience – réalisées récemment par des formateurs ; il présente également un essai de réflexion sur ces expériences à la manière de formateurs dans des moments de concertation pédagogique.

Pourquoi avions-nous choisi de travailler sur la bande dessinée ? Lorsque nous élucidons nos motivations, la première réponse qui nous frappe est celle-ci : « parce que ça existe ». C'est un monde qui imprègne la vie et la culture en France. C'est un mode de culture utilisé par les travailleurs immigrés : à nous de réfléchir avec eux et d'y découvrir ensemble les messages techniques et les messages culturels.

Nous avons donc utilisé la bande dessinée en essayant d'avoir dès le point de départ trois options pédagogiques :

1) Le monde de la bande dessinée est un monde ATTRAYANT.

Dans la recherche d'une pédagogie non « scolaire », il s'agissait de rendre intéressante une formation. Mais pour cela nous savons à priori que n'importe quelle bande et n'importe quel message n'avaient pas même valeur. Il s'agissait de choisir les centres d'intérêt et les modes d'exploitation.

2) Le monde de la bande dessinée est un des lieux privilégiés où se joue le problème de l'I NTERCULTUREL. Et pour nous, c'était un double problème :

-Pédagogique : dénotation et connotation d'une bande sont d'abord l'un et l'autre phénomène de cultures.

-Déontologie : Nous nous défendions de vouloir récupérer. Il s'agissait d'insérer dans une société française non de vouloir intégrer.

3) L'apprentissage de la bande dessinée nous semblait lié à la conquête de l'AUTONOMIE : l'immigré est agressé par un monde d'images qui est un des éléments « agresseur » de la civilisation dans laquelle il baigne : pour parvenir à son autonomie il doit se libérer peu à peu en apprenant à critiquer et maîtriser ces agressions.

Mais laissons là ces postulats de départ. Les expériences que nous présentons ne sont pas les seules qui sont réalisées dans notre organisme : nous n'avons voulu en présenter ici que deux.
Les réfugiés du Sud-Est asiatique dans l'école française
Authors: Lauran Annie
Published: November 2023

Depuis le printemps 1975, un nombre important d'enfants, venant de l’Asie du Sud-Est (Vietnam, Cambodge, Laos) sont entrés dans les écoles françaises.

D'après le Secours Catholique, il serait arrivé, entre le début de l'opération-refuge, et le milieu de l’année 1976, entre 12 et 14 000 personnes. Le Comité d’Entraide Franco-Vietnamien, Franco-Cambodgien et Franco-Laotien, estime que la moitié environ des réfugiés seraient des mineurs. Si l'on considère le nombre des réfugiés depuis le 1er juillet 1975, la proportion entre les nationalités serait la suivante :

3 553 Khmers

2 479 Vietnamiens

2 545 Laotiens

144 Thaïs

50 Chinois

(Chiffres communiqués par le Comité National de l’Entraide Franco-Vietnamien, Franco-Cambodgien et Franco-Laotien).
Analyser le français oral des immigrés
Authors: Véronique Daniel
Published: November 2023

Fréquemment, les animateurs de stages de formateurs centrent les apports de caractère linguistique sur l'analyse préalable de la langue, orale ou écrite, produite par les travailleurs immigrés, en situation réelle de communication.

Migrants-Formation a interviewé à propos de cette approche, Daniel Véronique, assistant en linguistique à l'université d’Aix-Marseille, et co-animateur de stages organisés par le CRFMA.
Réflexion sur les problèmes rencontrés en France par les réfugiés du Sud-Est Asiatique
Authors: Khamsay Soukhavong Pierre
Published: November 2023

Face à l’afflux soudain des réfugiés du Sud-Est asiatique en France, une partie de la presse, par manque de recul devant l’événement, a privilégié le goût du sensationnel et négligé l’analyse en profondeur. Il apparaît utile de rappeler que les réfugiés sont porteurs d’un mode de vie mais aussi d’un patrimoine culturel digne de respect et de compréhension.
La PSTI et les réfugiés asiatiques
Authors: Carpentier-Thomelet Catherine ,   Promotion sociale des travailleurs immigrés (PSTI)
Published: November 2023

La P.S.T.I. (Association-loi 1901 sans but lucratif, conventionnée avec le ministère du Travail et de la Participation) fondée en 1968, s’occupe depuis 1973 d’offrir aux migrants les structures nécessaires à leur promotion sociale : préformation et formation des jeunes, formation des adultes, logement, information.

Les activités menées par la P.S.T.I. sont ouvertes aux réfugiés d’Asie du Sud-Est. Certaines leur sont spécialement consacrées. Migrants-Formation est allé s’entretenir avec M. Peraldi, directeur de la P.S.T.I., Mme Peraldi, responsable de la préformation caissière-vendeuse, M. Gonin, conseiller-A.F.P.A. et conseiller pédagogique à la P.S.T.I., M. Touret, moniteur en formation générale aux stages de préformation.
Identification des besoins langagiers de travailleurs migrants en France
Authors: Porcher Louis
Published: November 2023

À l'initiative du Ministère de l'Education le CREDIF a été chargé, en 1977, d'une expérience d'identification des besoins langagiers des travailleurs migrants, s'inscrivant dans le cadre du projet n° 4 «Langues Vivantes» du Conseil de la Coopération Culturelle du Conseil de l'Europe.

Les objectifs de cette expérience furent les suivants :

- mise au point d'une méthodologie d'identification des besoins langagiers de travailleurs migrants, et des outils nécessaires à son application

- mise au point d'outils pédagogiques pour l'enseignement du français, langue étrangère, à des travailleurs migrants (outils pédagogiques élaborés à partir de «Un Niveau-Seuil»)

- étude d'une situation de formation où serait effectuée cette analyse des besoins langagiers, et expérimentés les outils pédagogiques.

Cette étude vient de faire l'objet d'une publicatio, dont nous présentons à nos lecteurs les remarques terminales.
California Burg : des jeunes fondent une société anonyme Interview réalisée par R.M. Lacaze
Authors: Lacaze Rose-Marie
Published: November 2023

Cet article et le suivant ne concernent pas les stages jeunes mais relatent des activités qui, à leur manière, constituent des actions de formation, l’une sur le tas (California Burg), l'autre dans une association de jeunes s'occupant de fugueuses.