bluuebunny/crossref_metadata_2025 huggingface dataset:
Centenarians Alleviate Inflammaging by Changing the Ratio and Secretory Phenotypes of T Helper 17 and Regulatory T Cells
Authors: Zhou Lixing , Ge Meiling , Zhang Yan , Wu Xiaochu , Leng Mi , Gan Chunmei , Mou Yi , Zhou Jiao , Valencia C Alexander , Hao Qiukui , Zhu Bin , Dong Biao , Dong Birong
Published: June 2022

The immune system of centenarians remains active and young to prevent cancer and infections. Aging is associated with inflammaging, a persistent low-grade inflammatory state in which CD4+ T cells play a role. However, there are few studies that have been done on the CD4+ T cell subsets in centenarians. Herein, the changes in CD4+ T cell subsets were investigated in centenarians. It was found that with aging, the old adults had higher levels of proinflammatory cytokines and lower levels of anti-inflammatory cytokines in plasma. The levels of CRP, IL-12, TNF-α, IFN-γ, IL-6 and IL-10 were further increased in centenarians compared to old adults. While the levels of IL-17A, IL-1β, IL-23 and TGF-β in centenarians were closer to those in young adults. The total CD4+, CD8+, Th17 and Treg cells from peripheral blood mononuclear cells (PBMCs) were similar among the three groups. It was observed that the ratio of Th17/Treg cells was elevated in old adults compared to young adults. The ratio was not further elevated in centenarians but rather decreased. In addition, the ex vivo PBMCs differentiation assay showed that increased Th17 cells in centenarians tended to secrete fewer proinflammatory cytokines, while decreased Treg cells in centenarians were prone to secrete more anti-inflammatory cytokines. These observations suggested centenarians alleviated inflammaging by decreasing the ratio of Th17/Treg cells and changing them into anti-inflammatory secretory phenotypes, which provided a novel mechanism for anti-aging research.
BMP-7 Upregulates Id2 Through the MAPK Signaling Pathway to Improve Diabetic Tubulointerstitial Fibrosis and the Intervention of Oxymatrine
Authors: Xiao Yawen , Liang Dan , Li Zhiyang , Feng Zhaowei , Yuan Zhiping , Zhang Fan , Wang Yuanyuan , Zhou Yuxia , Shi Mingjun , Liu Lingling , Xiao Ying , Guo Bing
Published: June 2022

Diabetic kidney disease is one of the most serious microvascular complications of diabetes. It progresses irreversibly to end-stage renal disease if left untreated. Bone morphogenetic protein (BMP)-7 is a negative regulator of organ fibrosis and may also play an essential role in tubulointerstitial fibrosis. This study aimed to investigate the precise role and potential molecular mechanisms of BMP-7 in the progression of diabetic nephropathy. In this study, BMP-7 was overexpressed in vivo after the replication of the diabetic rat model using streptozotocin. The results showed that BMP-7 inhibited the phosphorylation of related mitogen-activated protein kinase (MAPK) pathways while upregulating the inhibitor of differentiation (Id2) expression and effectively ameliorated pathological renal injury. Further in vitro validation showed that the inhibition of the phosphorylation of MAPKs at a high glucose concentration in renal tubular epithelial cells was followed by the upregulation of Id2 protein expression, suggesting that BMP-7 could improve diabetic nephropathy by upregulating Id2 protein levels through the BMP-7–MAPK signaling pathway. Previous laboratory studies found that oxymatrine improved renal fibrotic lesions. However, the exact mechanism is unclear. The present study showed that oxymatrine treatment in a diabetic rat model upregulated BMP-7 protein expression and inhibited MAPK pathway protein phosphorylation levels. These results suggested that oxymatrine improved the epithelial-to-mesenchymal transition process in the early stage of diabetic kidney disease by regulating the BMP-7–MAPK pathway and ameliorated renal tubulointerstitial fibrosis.
Neuroprotective Mechanisms of Ginsenoside Rb1 in Central Nervous System Diseases
Authors: Gong Liang , Yin Jiayi , Zhang Yu , Huang Ren , Lou Yuxuan , Jiang Haojie , Sun Liyan , Jia Jinjing , Zeng Xiansi
Published: June 2022

Panax ginseng and Panax notoginseng, two well-known herbs with enormous medical value in Asian countries, have a long usage history in China for the therapy of some diseases, such as stroke. Ginsenoside Rb1 is one of most important active ingredients in Panax ginseng and Panax notoginseng. In the last two decades, more attention has focused on ginsenoside Rb1 as an antioxidative, anti-apoptotic and anti-inflammatory agent that can protect the nervous system. In the review, we summarize the neuroprotective roles of ginsenoside Rb1 and its potential mechanisms in central nervous system diseases (CNSDs), including neurodegenerative diseases, cerebral ischemia injury, depression and spinal cord injury. In conclusion, ginsenoside Rb1 has a potential neuroprotection due to its inhibition of oxidative stress, apoptosis, neuroinflammation and autophagy in CNSDs and may be a promising candidate agent for clinical therapy of CNSDs in the future.
Lactylation may be a Novel Posttranslational Modification in Inflammation in Neonatal Hypoxic-Ischemic Encephalopathy
Authors: Zhou Yue , Yang Li , Liu Xiaoying , Wang Hao
Published: June 2022

Perinatal hypoxia-ischemia remains the most common cause of acute neonatal brain injury and is associated with a high death rate and long-term neurological abnormalities such as memory and cognitive deficits and dyskinesia. Hypoxia-ischemia triggers an inflammatory cascade in the brain that is amplified by the activation of immune cells and the influx of peripheral immune cells into the brain parenchyma in response to cellular injury. Thus, acute cerebral hypoxic-ischemic inflammation is a major contributor to the pathogenesis of newborn hypoxic-ischemic brain injury. Lactate is a glycolysis end product that can regulate inflammation through histone lactylation, a unique posttranslational modification that was identified in recent studies. The purpose of this review is to outline the recent improvements in our understanding of microglia-mediated hypoxic-ischemic inflammation and to further discuss how histone lactylation regulates inflammation by affecting macrophage activation. These findings may suggest that epigenetic reprogramming-associated lactate input is linked to disease outcomes such as acute neonatal brain injury pathogenesis and the therapeutic effects of drugs and other strategies in relieving neonatal hypoxic-ischemic brain injury. Therefore, improving our knowledge of the reciprocal relationships between histone lactylation and inflammation could lead to the development of new immunomodulatory therapies for brain damage in newborns.
Tracking Early Systolic Motion for Assessing Acute Response to Cardiac Resynchronization Therapy in Real Time
Authors: Villegas-Martinez Manuel , Krogh Magnus Reinsfelt , Andersen Øyvind S. , Sletten Ole Jakob , Wajdan Ali , Odland Hans Henrik , Elle Ole Jakob , Remme Espen W.
Published: June 2022

An abnormal systolic motion is frequently observed in patients with left bundle branch block (LBBB), and it has been proposed as a predictor of response to cardiac resynchronization therapy (CRT). Our goal was to investigate if this motion can be monitored with miniaturized sensors feasible for clinical use to identify response to CRT in real time. Motion sensors were attached to the septum and the left ventricular (LV) lateral wall of eighteen anesthetized dogs. Recordings were performed during baseline, after induction of LBBB, and during biventricular pacing. The abnormal contraction pattern in LBBB was quantified by the septal flash index (SFI) equal to the early systolic shortening of the LV septal-to-lateral wall diameter divided by the maximum shortening achieved during ejection. In baseline, with normal electrical activation, there was limited early-systolic shortening and SFI was low (9 ± 8%). After induction of LBBB, this shortening and the SFI significantly increased (88 ± 34%, p < 0.001). Subsequently, CRT reduced it approximately back to baseline values (13 ± 13%, p < 0.001 vs. LBBB). The study showed the feasibility of using miniaturized sensors for continuous monitoring of the abnormal systolic motion of the LV in LBBB and how such sensors can be used to assess response to pacing in real time to guide CRT implantation.
Demographic and Methodological Heterogeneity in Electrocardiogram Signals From Guinea Pigs
Authors: Haq Kazi T. , Cooper Blake L. , Berk Fiona , Roberts Anysja , Swift Luther M. , Posnack Nikki Gillum
Published: June 2022

Electrocardiograms (ECG) are universally used to measure the electrical activity of the heart; however, variations in recording techniques and/or subject demographics can affect ECG interpretation. In this study, we investigated variables that are likely to influence ECG metric measurements in cardiovascular research, including recording technique, use of anesthesia, and animal model characteristics. Awake limb lead ECG recordings were collectedin vivofrom adult guinea pigs using a platform ECG system, while recordings in anesthetized animals were performed using both a platform and needle ECG system. We report significant heterogeneities in ECG metric values that are attributed to methodological differences (e.g., ECG lead configuration, ECG recording platform, presence or absence of anesthesia) that persist even within the same cohort of animals. Further, we report that variability in animal demographics is preserved invivoECG recordings—with animal age serving as a significant contributor, while sex-specific influences were less pronounced. Methodological approaches and subject demographics should be fully considered when interpreting ECG values in animal models, comparing datasets between studies, or developing artificial intelligence algorithms that utilize an ECG database.
Development of Intron Polymorphism Markers and Their Association With Fatty Acid Component Variation in Oil Palm
Authors: Li Jing , Yang Yaodong , Sun Xiwei , Liu Rui , Xia Wei , Shi Peng , Zhou Lixia , Wang Yong , Wu Yi , Lei Xintao , Xiao Yong
Published: June 2022

Oil palm (Elaeis guineensis Jacq.) is a tropical woody oil crop of the palm family and is known as “the oil king of the world,” but its palm oil contains about 50% palmitic acid, which is considered unhealthy for humans. Intron polymorphisms (IP) are highly efficient and easily examined molecular markers located adjacent to exon regions of functional genes, thus may be associated with targeted trait variation. In order to speed up the breeding of oil palm fatty acid composition, the current study identified a total of 310 introns located within 52 candidate genes involved in fatty acid biosynthesis in the oil palm genome. Based on the intron sequences, 205 primer pairs were designed, 64 of which showed polymorphism among 70 oil palm individuals. Phenotypic variation of fatty acid content in the 70 oil palm individuals was also investigated. Association analysis revealed that 13 IP markers were significantly associated with fatty acid content variation, and these IP markers were located on chromosomes 2, 5, 6, 8, 9, and 10 of oil palm. The development of such IP markers may be useful for the genetic improvement of fatty acid composition in oil palm.
Expansion of the Strigolactone Profluorescent Probes Repertory: The Right Probe for the Right Application
Authors: de Saint Germain Alexandre , Clavé Guillaume , Schouveiler Paul , Pillot Jean-Paul , Singh Abhay-Veer , Chevalier Arnaud , Daignan Fornier Suzanne , Guillory Ambre , Bonhomme Sandrine , Rameau Catherine , Boyer François-Didier
Published: June 2022

Strigolactones (SLs) are intriguing phytohormones that not only regulate plant development and architecture but also interact with other organisms in the rhizosphere as root parasitic plants (Striga, Orobanche, and Phelipanche) and arbuscular mycorrhizal fungi. Starting with a pioneering work in 2003 for the isolation and identification of the SL receptor in parasitic weeds, fluorescence labeling of analogs has proven a major strategy to gain knowledge in SL perception and signaling. Here, we present novel chemical tools for understanding the SL perception based on the enzymatic properties of SL receptors. We designed different profluorescent SL Guillaume Clavé (GC) probes and performed structure-activity relationship studies on pea, Arabidopsis thaliana, and Physcomitrium (formerly Physcomitrella) patens. The binding of the GC probes to PsD14/RMS3, AtD14, and OsD14 proteins was tested. We demonstrated that coumarin-based profluorescent probes were highly bioactive and well-adapted to dissect the enzymatic properties of SL receptors in pea and a resorufin profluorescent probe in moss, contrary to the commercially available fluorescein profluorescent probe, Yoshimulactone Green (YLG). These probes offer novel opportunities for the studies of SL in various plants.
Global Context-Aware-Based Deformable Residual Network Module for Precise Pest Recognition and Detection
Authors: Jiao Lin , Li Gaoqiang , Chen Peng , Wang Rujing , Du Jianming , Liu Haiyun , Dong Shifeng
Published: June 2022

An accurate and robust pest detection and recognition scheme is an important step to enable the high quality and yield of agricultural products according to integrated pest management (IPM). Due to pose-variant, serious overlap, dense distribution, and interclass similarity of agricultural pests, the precise detection of multi-classes pest faces great challenges. In this study, an end-to-end pest detection algorithm has been proposed on the basis of deep convolutional neural networks. The detection method adopts a deformable residual network to extract pest features and a global context-aware module for obtaining region-of-interests of agricultural pests. The detection results of the proposed method are compared with the detection results of other state-of-the-art methods, for example, RetinaNet, YOLO, SSD, FPN, and Cascade RCNN modules. The experimental results show that our method can achieve an average accuracy of 77.8% on 21 categories of agricultural pests. The proposed detection algorithm can achieve 20.9 frames per second, which can satisfy real-time pest detection.
Extreme Low-Temperature Stress Affects Nutritional Quality of Amino Acids in Rice
Authors: Kang Min , Liu Gurong , Zeng Yaowen , Zhou Jia , Shi Jiangyi , Tang Liang , Liu Leilei , Cao Weixing , Zhu Yan , Liu Bing
Published: June 2022

Global climate change has increased the frequency of extreme climate events, and their effects on the nutritional quality, especially on amino acids in rice, have not been quantified. The data from a 3-year low temperature stress (LTS) experiment including two rice varieties (Huaidao 5 and Nanjing 46), seven minimum/maximum temperature levels (one optimal 21/27°C and six LTS levels from 17/23 to 6/12°C), and three LTS durations (3, 6, and 9 days) after flowering, revealed significant interactive effects of LTS at different stages, durations, and temperature levels on the content and accumulation of amino acids. LTS increased rice total amino acid content, while decreasing its accumulation, with higher sensitivities to LTS at the flowering stage than at the grain filling stage. In most treatments, the lysine (the first limiting amino acid) and phenylalanine content were increased under LTS at early and peak flowering stages but decreased at the grain filling stage in both varieties, and only leucine content was increased at all three stages after flowering, while the content of other essential amino acids differed among the two varieties. With an increase of 1°C·d per day in the accumulated cold degree days, the relative content of the essential amino acids was increased by 0.01–0.41%, depending on the rice variety and growth stage. Our results suggest that LTS can improve nutritional quality of amino acids of rice grains in terms of amino acids content, especially at flowering stage. These results provide critical insights for assessing the potential impact of extreme climates on the nutrient quality of rice under future climate change.
Effects of Fruit Shading on Gene and Protein Expression During Starch and Oil Accumulation in Developing Styrax tonkinensis Kernels
Authors: Wu Qikui , Chen Hong , Zhang Zihan , Chen Chen , Yu Fangyuan , Guy Robert D.
Published: June 2022

Styrax tonkinensis has great potential as a biofuel feedstock source having industrial oilseeds with excellent fatty acids (FAs) composition and good fuel properties. Photosynthesis in the developing pericarp could affect the carbon distribution in kernel. During kernel development, more carbon sources are allocated to starch rather than lipid, when the pericarp photosynthesis is reduced by fruit shading treatment. After shading the fruits at 50 days after flowering (DAF), samples of shaded fruit (FSK) and controls (CK) were collected at 80 DAF and analyzed using the proteomic method. We identified 3,181 proteins, of which 277 were differentially expressed proteins, all downregulated in the FSK group. There were 56 proteins found involved in carbohydrate metabolism and lipid biosynthesis leading to oil accumulation with their iTRAQ ratios of FSK/CK ranging from 0.7123 to 1.1075. According to the qRT-PCR analyses, the key genes related to FA and triacylglycerol (TAG) biosynthesis were significantly downregulated between 60 and 90 DAF especially at 80 DAF, while the key genes involved in starch biosynthesis and FA desaturase had no significant difference between the two groups at 80 DAF. Fruit shading is a negative treatment for lipid accumulation but not starch accumulation by restraining enzymic protein expression involved in FA and TAG biosynthesis during S. tonkinensis kernel development.
Tandem Mass Tag-Based Quantitative Proteomics Reveals Implication of a Late Embryogenesis Abundant Protein (BnLEA57) in Seed Oil Accumulation in Brassica napus L.
Authors: Zhou Zhongjing , Lin Baogang , Tan Jinjuan , Hao Pengfei , Hua Shuijin , Deng Zhiping
Published: June 2022

Enhancing oil content is one of the major goals in Brassica napus breeding; however, genetic regulation of seed oil content in plants is complex and not fully elucidated. In this study, we report proteins that were differentially accumulated in immature seeds of 35 days after anthesis between two recombinant inbred lines with contrasting seed oil content, high oil content line (HOCL) and low oil content line (LOCL) using a multiplex isobaric tandem mass tags (TMT)-based quantitative proteomic approach. Over 4,600 proteins were quantified in seeds of the two lines, and 342 proteins showed differential accumulation between seeds of HOCL and LOCL. Gene Ontology enrichment analysis revealed that the differentially accumulated proteins were enriched in proteins involved in lipid biosynthesis and metabolism, photosynthesis, and nutrient reservoir activity. Western blot confirmed the increased abundance of a late embryogenesis abundant protein (BnLEA57) in HOCL seeds compared with LOCL seeds, and overexpression of either BnLEA57 gene or its homology BnLEA55 in transgenic Arabidopsis thaliana enhanced oil content in Arabidopsis seeds. Our work provides new insights into the molecular regulatory mechanism of seed oil content in B. napus.
Stepped Geomorphology Shaped the Phylogeographic Structure of a Widespread Tree Species (Toxicodendron vernicifluum, Anacardiaceae) in East Asia
Authors: Wang Lu , Li Yao , Noshiro Shuichi , Suzuki Mitsuo , Arai Takahisa , Kobayashi Kazutaka , Xie Lei , Zhang Mingyue , He Na , Fang Yanming , Zhang Feilong
Published: June 2022

Species’ phylogeographic patterns reflect the interplay between landscape features, climatic forces, and evolutionary processes. Here, we used two chloroplast DNA (cpDNA) markers (trnL and trnL-F) to explore the role of stepped geomorphology in shaping the phylogeographic structure of Toxicodendron vernicifluum, an economically important tree species widely distributed in East Asia. The range-wide pattern of sequence variation was analyzed based on a dataset including 357 individuals from China, together with published sequences of 92 individuals mainly from Japan and South Korea. We identified five chloroplast haplotypes based on seven substitutions across the 717-bp alignment. A clear east-west phylogeographic break was recovered according to the stepped landforms of mainland China. The wild trees of the western clade were found to be geographically restricted to the “middle step”, which is characterized by high mountains and plateaus, while those of the eastern clade were confined to the “low step”, which is mainly made up of hills and plains. The two major clades were estimated to have diverged during the Early Pleistocene, suggesting that the cool glacial climate may have caused the ancestral population to retreat to at least two glacial refugia, leading to allopatric divergence in response to long-term geographic isolation. Migration vector analyses based on the outputs of ecological niche models (ENMs) supported a gradual range expansion since the Last Interglacial. Mountain ranges in western China and the East China Sea land bridge were inferred to be dispersal corridors in the western and eastern distributions of T. vernicifluum, respectively. Overall, our study provides solid evidence for the role of stepped geomorphology in shaping the phylogeographic patterns of T. vernicifluum. The resulting east-west genetic discontinuities could persist for a long time, and could occur at a much larger scale than previously reported, extending from subtropical (e.g., the Xuefeng Mountain) to warm-temperate China (e.g., the Taihang Mountain).
The Ups and Downs of Plant NLR Expression During Pathogen Infection
Authors: Fick Alicia , Swart Velushka , van den Berg Noëlani
Published: June 2022

Plant Nucleotide binding-Leucine rich repeat (NLR) proteins play a significant role in pathogen detection and the activation of effector-triggered immunity. NLR regulation has mainly been studied at a protein level, with large knowledge gaps remaining regarding the transcriptional control of NLR genes. The mis-regulation of NLR gene expression may lead to the inability of plants to recognize pathogen infection, lower levels of immune response activation, and ultimately plant susceptibility. This highlights the importance of understanding all aspects of NLR regulation. Three main mechanisms have been shown to control NLR expression: epigenetic modifications, cis elements which bind transcription factors, and post-transcriptional modifications. In this review, we aim to provide an overview of these mechanisms known to control NLR expression, and those which contribute toward successful immune responses. Furthermore, we discuss how pathogens can interfere with NLR expression to increase pathogen virulence. Understanding how these molecular mechanisms control NLR expression would contribute significantly toward building a complete picture of how plant immune responses are activated during pathogen infection—knowledge which can be applied during crop breeding programs aimed to increase resistance toward numerous plant pathogens.
Walking the Tightrope of Job Demands and Resources: Leveraging Work Engagement to Counter Turnover Intentions of Information Technology Professionals
Authors: Van Heerden Jana , Du Plessis Marieta , Becker Jurgen R.
Published: June 2022

Organisations within the banking industry are increasingly confronted with attraction and retention challenges within their Information Technology (IT) divisions, driven by an increase in demand for skilled resources within the market. Therefore, the primary objective of the study was to explore the impact of job resources and job demands on work engagement and employee turnover intentions within the IT division of a South African bank. The Job Demands-Resources (JD-R) model was applied as theoretical framework to identify the unique job resources and job demands driving work engagement and turnover intentions of employees within this highly specialised section of the South African banking industry. Quantitative data was collected from 239 IT professionalsviaa self-administered, web-based survey measuring work engagement, job demands and resources, and turnover intentions. After confirmation of the factor structures of each of the variables, the direct and indirect relationships between the variables were analysed. The results indicate statistically significant relationships between job resources, work engagement and turnover intentions. Job demands moderated the relationship between job resources and work engagement, whilst work engagement mediated the relationship between job resources and turnover intention. By applying the JD-R model as a theoretical framework for the study, the unique job resources and job demands as drivers of work engagement and turnover intentions of IT employees could be highlighted to direct the development of focused work engagement and retention strategies.
The Power of a Profound Experience With Nature: Living With Meaning
Authors: Mathers Becky , Brymer Eric
Published: June 2022

Nature based experiences have been linked to significant positive outcomes for people and the planet. Significant life experience research investigates the associations between formative experiences in nature and resulting environmental concern and action, including both singular events and repeated experiences. However, little is known about the long-term impacts of singular profound experiences with nature. This research sought to better understand how a singular, meaningful experience defines an individual’s self-awareness of his or her relationship with nature, changes social relationships, and directs environmental decisions and behaviors. Twenty-one adults who had a profound experience with nature participated in a semi-structured interview exploring how they make sense of their experience, the meaning they attribute to it, and the role it served in their lives. Three themes resulted from the thematic analysis process: (1) Living in relation with nature, (2) Living authentically, and (3) Living a meaningful life. The findings demonstrate that a single profound experience with nature can have long-lasting and significant effects on an individual. Understanding these long-term influences of a profound experience with nature have implications for intervention designers such as health practitioners and environmental educators, as well as policy-makers.
School Psychological Environment and Learning Burnout in Medical Students: Mediating Roles of School Identity and Collective Self-Esteem
Authors: Yu Wanwan , Yang Shuo , Chen Ming , Zhu Ying , Meng Qiujian , Yao Wenjun , Bu Junjie
Published: June 2022

Learning burnout is an important indicator that reflects an individual’s learning state. Understanding the influencing factors and mechanism of learning burnout of medical students has practical significance for improving their mental health. This study aimed to explore the mediating roles of school identity and collective self-esteem between school psychological environment and learning burnout in medical students. A total of 2,031 medical students (942 men and 1,089 women, age range: 17–23 years) were surveyed using the School Psychological Environment Questionnaire (SPEQ), School Identity Questionnaire (SIQ), Collective Self-esteem Scale (CSES), and Learning Burnout Scale (LBS). The results showed the following: (1) school psychological environment had a negative effect on learning burnout among medical students (β = −0.19, p < 0.001), and (2) school identity and collective self-esteem played significant mediating roles between school psychological environment and learning burnout [95% CI = (−0.43, −0.31)]. Specifically, there were three paths that school psychological environment and learning burnout: first, through the independent mediating role of school identity; second, through the independent mediating role of collective self-esteem; and third, through the chain mediating roles of school identity and collective self-esteem. The findings reveal that school psychological environment not only directly influences the learning burnout of medical students but also indirectly influences it through school identity and collective self-esteem. Thus, this study has some important implications for prevention and intervention of learning burnout among medical students.
Research Methods in a Multinational Business Environment and Implications for Capital Formation: Application of Cross-Sectional Autoregressive Distributed Lag Methods
Authors: Halwan Musaad M. , Bin Zhang Y. , Ameer Waqar , Mumtaz Nosheen , Mumtaz Ayesha , Amin Azka
Published: June 2022

We explore whether foreign direct investment outflows augment or obstruct public or private capital in developing countries by decomposing domestic capital into private and public capital. While developed countries are the primary source of foreign direct investment outflows (FDIOs), developing economies have become the primary source of FDIO over the past 30 years. We apply cross-sectional autoregressive distributed lag (CS-ARDL) methods to overcome the issue of endogeneity and cross-sectional dependency in our dataset. This study analyzes the interaction effects of foreign direct investment and institutional quality (IQ) in promoting aggregate domestic capital formation in developing countries. Our empirical results show that FDI outflows augment private capital formation and additionally, IQ also upsurges private capital formation. Conversely, as per results, FDI outflows obstruct public capital formation, and IQ crowds out public capital formation significantly while private capital crowds out FDI inflows. As per result estimations, we notice that FDIO crowds in private capital formation, thus we conclude that the private sector controls the majority of the sectors for developing countries and the role of the public sector is quite minimal. We conclude that private and public capital possess different attributes; thus clubbing them together might result in aggregation bias. Our result estimations provide several useful policy implications.
Formality or Reality: Student Teachers’ Experiences of Ethical Dilemmas and Emotions During the Practicum
Authors: Wang Xin , Liu Denghui , Liu Jingyan
Published: June 2022

The main purpose of the study was to explore Chinese student teachers’ experience during their practicum and what they reported as ethical dilemmas and how these experiences affected them in terms of professional development as well as emotional well-being. Through the analysis of qualitative data collected from forty-three participants’ interviews, this study identified six most commonly reported ethical dilemmas, including: formal curriculum versus informal and hidden curriculum; family agenda versus educational standards; loyalty to colleagues versus school norms; confidentiality versus school rules; conformism dilemmas and red-envelope dilemmas and found that dilemmas about formal curriculum versus informal and hidden curriculum were the dominant workplace ethical dilemma for student teachers. The results also showed that the majority of the student teachers reported experiencing negative emotions or painful memories, which may hinder their development of professional competencies and overall wellbeing. Thus, the study argues that student teachers’ frequent encounters with ethical dilemmas highlight the challenges faced by teacher educators in transferring knowledge between university and school environments, and student teachers should be equipped with essential emotional regulation strategies that could benefit them in their future work.
A Closer Look at the Birth Order Effect on Early Cognitive and School Readiness Development in Diverse Contexts
Authors: Luo Rufan , Song Lulu , Chiu I-Ming
Published: June 2022

Using the Early Childhood Longitudinal Study–Birth Cohort data, we examined the effect of birth order (firstborn vs. later-born) on children's cognitive skills at 24 months and school readiness (i.e., math and literacy) skills at age 4 years. Previous research in the U.S. using predominantly English-speaking, low-risk samples suggests that firstborns tend to show better early cognitive and school readiness skills than later-born children. However, results of the current study showed that although there was a firstborn advantage in low-risk or English-speaking families, in high-risk or language minority families, later-born children showed equivalent or even better skills than firstborn children. Our moderated mediation models revealed that children's engagement in home learning activities mediated the relation between birth order and developmental outcomes, and families' cumulative risks and language minority status moderated the mediation pathways. These findings underscore the complex associations between birth order and early development in diverse ecological contexts.
More Power, More Warmth: The Enhancing Effect of Power on the Perceived Warmth About High-Power Individuals Under Chinese Culture
Authors: Li Minyan , Yang Feng , Han Yang
Published: June 2022

Previous literature concerning power stereotypes demonstrates that compared to low-power (LP) individuals, high-power (HP) individuals tend to be perceived as having positive competence but negative warmth. Based on previous research, the current research further classified HP into senior and junior HP and mainly compared the perceived warmth between senior and junior HP individuals in Chinese culture. By classifying power into HP and LP, the pilot study employed the trait-rating task to replicate the results of previous research. In Study 1, we classified HP into senior and junior HP and revealed that participants indicated more positive warmth evaluations for senior HP individuals than for junior HP individuals. We named this “more power, more warmth” effect the MPMW effect. Further investigation demonstrated that the MPMW effect was more likely to emerge for participants with high Confucianism identification (Study 2a), for Chinese participants rather than Western participants (Study 2b), or when the knowledge of Confucianism was accessible in a given situation (Study 3). The present research firstly demonstrated that the contents of power stereotypes may partially display culture-specific characteristics in Chinese culture. The continuous classification approach to power provided a novel insight for future power research.
Internationalization Issues in Chinese Firms: One Belt, One Road-Based Perspective
Authors: Wu Xia
Published: June 2022

The underlying aim of this study was to investigate the impact of human resource management (HRM) practices, organizational identity, and brand leadership on employee brand-based equity through the mediatory role of brand knowledge dissemination. A questionnaire was adopted to obtain data from 421 employees working in the construction sector of China. The SmartPLS software was used to analyze the data with the help of a structural equation modeling (SEM) technique. The results revealed that HRM practices and organizational identity had a positive and significant relationship with employee brand-based equity, while brand leadership had no direct impact on employee brand-based equity. The results also revealed that brand knowledge dissemination mediated the relationship between independent variables (HRM practices, organizational identity, and brand leadership) and dependent variable (employee brand-based equity). Theoretically, this paper made a valuable contribution by examining the impact of HRM practices, organizational identity, and brand leadership on employee brand-based equity. In terms of practical implications, this study would obviously help the organizations to improve their employee brand-based equity through HRM practices and organizational identity.
Involuntary Career Changes: A Lonesome Social Experience
Authors: Masdonati Jonas , Frésard Caroline É. , Parmentier Michaël
Published: June 2022

Like any other career process, career changes are influenced by relationships. Moreover, involuntary career changes are a challenging, yet understudied, career transition. Based on a relational perspective of work and careers, we investigated the way people’s social environment affects the process and experience of involuntary career changes. Specifically, we aimed to identify the sources of relational influences and to understand how these influences affect career changes. Semi-structured interviews were carried out with 14 adults who were forced to change career because of unemployment or health issues. Through thematic analysis, we identified three sources of relational influences (personal, work, and institutional environment) and three forms of influence that others had on career changes (positive, negative, and ambivalent). These influences manifested at four distinct moments of the process: When participants were leaving their former job, when they were shifting between their former occupation and a new livelihood, when they were exploring new career options, or when they were trying to implement their new career plan. Overall, results suggest that involuntary career changes are deeply shaped by heterogeneous and differentiated relational influences. The effect of the personal environment varied depending on the moment of the career change process. In particular, family and friends tended to be perceived as barriers when it came to shifting from the old to a new occupation and implementing a new career plan. The work environment mostly had a negative effect on the career change experience, suggesting the labor market might be somewhat refractory toward adult career changers. Institutions played a critical role throughout the change process, with support structures often being perceived as inappropriate, but with guidance professionals generally recognizing participants’ difficulties. Moreover, diverse forms of ambivalence characterized the identified relational influences, which were sometimes both appreciated and avoided or had ambiguous and fluctuating effects. Finally, although being a fundamentally social experience, involuntary career changes were also characterized by moments of loneliness that reflected the inadequacy of available support and a sense of shame associated with the status of career changer. Study limitations, research perspectives, and practical implications at the labor market, institutional, and individual levels are addressed.
Andean Women’s Persistence Amidst Racialized Gendered Impoverishment, Capitalist Incursions, and Post-conflict Hauntings
Authors: Távara Gabriela , Lykes M. Brinton
Published: June 2022

Throughout the last four decades, Andean women from the highland communities of Peru have been significantly affected by ongoing neoliberal capitalist development and patriarchal structures. These intersecting violence(s) took on more horrific dimensions during the Peruvian armed conflict (1980–2000) and have contributed to multiple psychosocial sequelae that linger in the daily lives on these communities as “ghostly matters.” Seeking to face these experiences in a context of ongoing material impoverishment, Andean women from highland communities have initiated multiple associations or economic collective projects. The authors accompanied a group of women who formed a knitting association and facilitated a feminist participatory action research (FPAR), creating opportunities through which these women could engage in action-reflection processes toward enhancing their association. Twelve women from this FPAR process agreed to be interviewed by the first author who sought to explore their understandings about the processes of forming their association in this post-conflict context and the challenges they were facing. Interview transcripts were analyzed using Charmaz’s constructivist grounded theory coding strategy. The findings reveal multiple challenges for women’s collaborative work created by ongoing racialized gendered violence and its intra- and interpersonal effects. Moreover, the findings confirmed that capitalist development dynamics, and, more particularly, resources introduced by agents from outside the community, bring both gains and losses for Andean women. The latter reported having learned skills that allowed them to better insert themselves in a market economy, but that these new activities were displacing more community-based Indigenous practices and traditions. Finally, this study reveals that the wounds created by the armed conflict generated multiple forms of silence that prevent Andean peasants from openly expressing their desires. Despite this, the women in this FPAR process and participants in these interviews are engaging in action-based responses through which they are overcoming some of these challenges and sustaining their association. The article concludes with a discussion of the implications for mental health professionals and activist-scholars working with Indigenous communities affected by armed conflict by underscoring the limitations of interventions based exclusively on the spoken word and arguing for action-based approaches that draw on bottom-up knowledge and practices.
Describing Patterns of Known Domestic Abuse Among Different Ethnic Groups
Authors: Bland Matthew , Weir Ruth , Adisa Olumide , Allen Katherine , Ferreira Joana , Maitra Dev Rup
Published: June 2022

Domestic abuse perpetration remains a major threat to public health, safety and wellbeing, causing serious harms and contributing significantly to overall crime globally. In the United Kingdom, research links the crime type to high economic and social costs. In the last 10 years, our collective knowledge of domestic abuse has grown in conjunction with its prioritisation in government policy. Several innovative studies have built a picture of the most serious cases and overall patterns of abuse but to date, examination of these trends by ethnic groups has been limited despite increasing attention to disproportionality in racially minoritised communities in criminal justice system outcomes. In this article we aimed to address this issue through the analysis of 150,000 domestic abuse records kept by police forces in England. Using descriptive statistics, we examined the relative distributions of different ethnicities by suspected offending rate, investigative outcome and crime harm. We found two patterns of note: firstly, that suspects from several categories of minoritized communities are consistently over-represented compared to the White British population among most harmful cases, and secondly, that in Asian communities, offences are less frequently “solved.” We discuss the implications for future research and practice.
Maternal Immune Dysregulation and Autism–Understanding the Role of Cytokines, Chemokines and Autoantibodies
Authors: McLellan Janna , Kim Danielle H. J. , Bruce Matthew , Ramirez-Celis Alexandra , Van de Water Judy
Published: June 2022

Autism spectrum disorder (ASD) is acknowledged as a highly heterogeneous, behaviorally defined neurodevelopmental disorder with multiple etiologies. In addition to its high heritability, we have come to recognize a role for maternal immune system dysregulation as a prominent risk factor for the development of ASD in the child. Examples of these risk factors include altered cytokine/chemokine activity and the presence of autoantibodies in mothers that are reactive to proteins in the developing brain. In addition to large clinical studies, the development of pre-clinical models enables the ability to evaluate the cellular and molecular underpinnings of immune-related pathology. For example, the novel animal models of maternal autoantibody-related (MAR) ASD described herein will serve as a preclinical platform for the future testing of targeted therapeutics for one ‘type’ of ASD. Identification of the cellular targets will advance precision medicine efforts toward tailored therapeutics and prevention. This minireview highlights emerging evidence for the role of maternal immune dysregulation as a potential biomarker, as well as a pathologically relevant mechanism for the development of ASD in offspring. Further, we will discuss the current limitations of these models as well as potential avenues for future research.
Correlation Between the Functional Connectivity of Basal Forebrain Subregions and Vigilance Dysfunction in Temporal Lobe Epilepsy With and Without Focal to Bilateral Tonic-Clonic Seizure
Authors: Fan Binglin , Pang Linlin , Li Siyi , Zhou Xia , Lv Zongxia , Chen Zexiang , Zheng Jinou
Published: June 2022

Purpose

Previous research has shown that subcortical brain regions are related to vigilance in temporal lobe epilepsy (TLE). However, it is unknown whether alterations in the function and structure of basal forebrain (BF) subregions are associated with vigilance impairment in distinct kinds of TLE. We aimed to investigate changes in the structure and function BF subregions in TLE patients with and without focal to bilateral tonic-clonic seizures (FBTCS) and associated clinical features.

Methods

A total of 50 TLE patients (25 without and 25 with FBTCS) and 25 healthy controls (HCs) were enrolled in this study. The structural and functional alterations of BF subregions in TLE were investigated using voxel-based morphometry (VBM) and resting-state functional connectivity (rsFC) analysis. Correlation analyses were utilized to investigate correlations between substantially altered imaging characteristics and clinical data from patients.

Results

FBTCS patients had a lower rsFC between Ch1-3 and the bilateral striatum as well as the left cerebellum posterior lobe than non-FBTCS patients. In comparison to non-FBTCS patients, the rsFC between Ch4 and the bilateral amygdala was also lower in FBTCS patients. Compared to HCs, the TLE patients had reduced rsFC between the BF subregions and the cerebellum, striatum, default mode network, frontal lobe, and occipital lobes. In the FBTCS group, the rsFC between the left Ch1-3 and striatum was positive correlated with the vigilance measures. In the non-FBTCS group, the rsFC between the left Ch4 and striatum was significantly negative correlated with the alertness measure.

Conclusion

These results extend current understanding of the pathophysiology of impaired vigilance in TLE and imply that the BF subregions may serve as critical nodes for developing and categorizing TLE biomarkers.
Threat to Professional Autonomy and Physicians' Intention to Use Acupuncture: A Study From Malaysia
Authors: Daher Aqil M. , Ong Siew Siew , Krisnan Devanandhini
Published: June 2022

Despite its popularity, registered medical practitioners (RMPs) are reluctant to use acupuncture in their practice. The aim of this study is to determine the impact of Threat to Professional Autonomy (TPA) on RMPs' intention to use acupuncture in Malaysia. A cross sectional study was conducted using an online survey form. The survey was distributed to 250 registered medical practitioners who are affiliated with the Malaysian Medical Association. The questionnaire followed a modified technology acceptance theoretical framework including the three main constructs of ease of use, usefulness and intention to use with addition of TPA as a predictor of physician intention. Structural equation modeling (SEM) was utilized to test the relationship between the 4 constructs. Measurement model, discriminant validity and path analysis statistics were presented. Two hundred and seventeen returned the completed questionnaire yielding a response rate of 86.8%. In the measurement model, all items within each construct were highly correlated. The minimum average variance extracted (AVE) was 0.741. All constructs achieved a minimum of 0.896 reliability estimates. Discriminant validity was ascertained with the findings that the square root of AVE is larger than the correlation between each two constructs. TPA has a significant negative impact on ease of use (p < 0.001) and perceived usefulness (p = 0.002). There was no significant direct effect of TPA on intention (p = 0.0561). Fit indices showed adequate fit. In conclusion, TPA affects the intention to use acupuncture indirectly through its negative effect on perceived ease of use and perceived usefulness of acupuncture.