bluuebunny/crossref_metadata_2025 huggingface dataset:
Capacity- and energy-aware activation of sensor nodes for area phenomenon reproduction using wireless network transport
Authors: Huang Xiaolong , Rubin Izhak
Published: July 2013

We consider a sensor network involving sensors placed in specific locations. An area phenomenon is detected and tracked by activated sensors. The area phenomenon is modeled to consist of
K
spatially distributed point phenomena. The activated sensors collect data samples characterizing the parameters of the involved point phenomena. They compress observed data readings and transport them to a processing center. The center processes the received data to derive estimates of the point phenomena's parameters. Our sensing stochastic process models account for distance-dependent observation noise perturbations as well as noise correlations. At the processing center, sample mean calculations are used to derive the estimates of the underlying area phenomenon's parameters. We develop computationally efficient algorithms to determine the specific set of sensors for activation under capacity and energy resource constraints so that a sufficiently low reproduction distortion level is attained. We derive lower bounds on the realizable levels of the distortion measure. Using illustrative cases, we demonstrate one of our algorithms to yield distortion levels that are very close to the lower bound, while other lower-complexity schemes often yield distortion levels relatively close to the lower bound.
Evaluating an element of the Clarke generalized Jacobian of a composite piecewise differentiable function
Authors: Khan Kamil A. , Barton Paul I.
Published: July 2013

Bundle methods for nonsmooth optimization and semismooth Newton methods for nonsmooth equation solving both require computation of elements of the (Clarke) generalized Jacobian, which provides slope information for locally Lipschitz continuous functions. Since the generalized Jacobian does not obey sharp calculus rules, this computation can be difficult. In this article, methods are developed for evaluating generalized Jacobian elements for a nonsmooth function that is expressed as a finite composition of known elemental piecewise differentiable functions. In principle, these elemental functions can include any piecewise differentiable function whose analytical directional derivatives are known. The methods are fully automatable, and are shown to be computationally tractable relative to the cost of a function evaluation. An implementation developed in C++ is discussed, and the methods are applied to several example problems for illustration.
Reducing the influence of tiny normwise relative errors on performance profiles
Authors: Dingle Nicholas J. , Higham Nicholas J.
Published: July 2013

It is a widespread but little-noticed phenomenon that the normwise relative error ‖
x - y
‖/‖
x
‖ of vectors
x
and
y
of floating point numbers of the same precision, where
y
is an approximation to
x
, can be many orders of magnitude smaller than the unit roundoff. We analyze this phenomenon and show that in the ∞-norm it happens precisely when
x
has components of widely varying magnitude and every component of
x
of largest magnitude agrees with the corresponding component of
y
. Performance profiles are a popular way to compare competing algorithms according to particular measures of performance. We show that performance profiles based on normwise relative errors can give a misleading impression due to the influence of zero or tiny normwise relative errors. We propose a transformation that reduces the influence of these extreme errors in a controlled manner, while preserving the monotonicity of the underlying data and leaving the performance profile unchanged at its left end-point. Numerical examples with both artificial and genuine data illustrate the benefits of the transformation.
On Ziv's rounding test
Authors: de Dinechin Florent , Lauter Christoph , Muller Jean-Michel , Torres Serge
Published: July 2013

A very simple test, introduced by Ziv, allows one to determine if an approximation to the value
f(x)
of an elementary function at a given point
x
suffices to return the floating-point number nearest
f(x)
. The same test may be used when implementing floating-point operations with input and output operands of different formats, using arithmetic operators tailored for manipulating operands of the same format. That test depends on a “magic constant”
e
. We show how to choose that constant
e
to make the test reliable and efficient. Various cases are considered, depending on the availability of an fma instruction, and on the range of
f(x)
.
Algorithm 930
Authors: Davis Timothy A.
Published: July 2013

The MATLAB™ backslash (x=A\b) is an elegant and powerful interface to a suite of high-performance factorization methods for the direct solution of the linear system
Ax
=
b
and the least-squares problem min

x

‖
b - Ax
‖. It is a meta-algorithm that selects the best factorization method for a particular matrix, whether sparse or dense. However, the simplicity and elegance of its single-character interface prohibits the reuse of its factorization for subsequent systems. Requiring MATLAB users to find the best factorization method on their own can lead to suboptimal choices; even MATLAB experts can make the wrong choice. Furthermore, naive MATLAB users have a tendency to translate mathematical expressions from linear algebra directly into MATLAB, so that
x
=
A
-1
b
becomes the inferior yet all-to-prevalent x=inv(A)*b. To address these issues, an object-oriented FACTORIZE method is presented. Via simple-to-use operator overloading, solving two linear systems can be written as F=factorize(A); x=F\b; y=F\c, where A is factorized only once. The selection of the best factorization method (LU, Cholesky,

LDL
T

, QR, or a complete orthogonal decomposition for rank-deficient matrices) is hidden from the user. The mathematical expression
x
=
A
-1
b
directly translates into the MATLAB expression x=inverse(A)*b, which does not compute the inverse at all, but does the right thing by factorizing A and solving the corresponding triangular systems.
Patient, heal thyself
Authors: Wright Alex
Published: July 2013

New handheld medical diagnostic tools promise more efficient, lower-cost healthcare---but at what price?
A Haptic Tool for Group Work on Geometrical Concepts Engaging Blind and Sighted Pupils
Authors: Moll Jonas , Pysander Eva-Lotta Sallnäs
Published: July 2013

In the study presented here, two haptic and visual applications for learning geometrical concepts in group work in primary school have been designed and evaluated. The aim was to support collaborative learning among sighted and visually impaired pupils. The first application is a static flattened 3D environment that supports learning to distinguish between angles by means of a 3D haptic device providing touch feedback. The second application is a dynamic 3D environment that supports learning of spatial geometry. The scene is a room with a box containing geometrical objects, which pupils can pick up and move around. The applications were evaluated in four schools with groups of two sighted and one visually impaired pupil. The results showed the support for the visually impaired pupil and for the collaboration to be satisfying. A shared understanding of the workspace could be achieved, as long as the virtual environment did not contain movable objects. Verbal communication was crucial for the work process but haptic guiding to some extent substituted communication about direction. When it comes to joint action between visually impaired and sighted pupils a number of interesting problems were identified when the dynamic and static virtual environments were compared. These problems require further investigation. The study extends prior work in the areas of assistive technology and multimodal communication by evaluating functions for joint haptic manipulation in the unique setting of group work in primary school.
The ethics of online anonymity or Zuckerberg vs. "Moot"
Authors: Bodle Robert
Published: July 2013

This paper argues that anonymity in networked digital communications is indispensable as an enabler of other inalienable rights including informational privacy and freedom of expression. Yet, an alignment of industry norms, practices, ethics, and techno-social design asserts a persistent identity ecosystem, making online anonymity more difficult to achieve. This paper reappraises the democratic uses, affordances, and human rights dimensions of online anonymity in order to advance an ethical justification for its protection.
Collective intelligence and ethical individualism
Authors: Volkman Richard
Published: July 2013

Many commentators conceive the self in either atomistic or holistic terms, even as our understanding of the self as a node of processing within the wider network for revealing the "wisdom of crowds" has long transcended this dichotomy. Understanding the self as a "center of narrative gravity" leaves room for a robust individualism in the context of rich sociality. Such a conception is already present in the classic individualism of the 19
th
Century and supports optimism that digital culture at once encourages individual flourishing and cultural progress alike.
Data stream processing with concurrency control
Authors: Oyamada Masafumi , Kawashima Hideyuki , Kitagawa Hiroyuki
Published: July 2013

A recent trend in data stream processing shows the use of advanced continuous queries (CQs) that reference non-streaming resources such as relational data in databases and machine learning models. Since non-streaming resources could be shared among multiple systems, resources may be updated by the systems during the CQ-execution. As a consequence, CQs may reference resources inconsistently, and lead to a wide range of problems from inappropriate results to fatal system failures. In this paper, we address this inconsistency problem by introducing the concept of transaction processing onto data stream processing.

In the first part of this paper, we introduce
CQ-derived transaction
, a concept that derives read-only transactions from CQs, and illustrate that the inconsistency problem is solved by ensuring serializability of derived transactions and resource updating transactions. To ensure serializability, we propose three CQ-processing strategies based on concurrency control techniques: two-phase lock strategy, snapshot strategy, and optimistic strategy. Experimental study shows our CQ-processing strategies guarantee proper results, and their performances are comparable to the performance of conventional strategy that could produce improper results.

In the second part of this paper, we try to improve the performance of our proposed strategies from the viewpoint of operator scheduling. We notice a characteristic of our proposed strategies: operators could be re-evaluated to prevent non-serializable schedules causing performance degradation. We find the fact that the number of operator re-evaluation depends on operator scheduling, and propose a scheduling constraint that reduces the re-evaluation. Experimental study shows our constraint's effectiveness: if we add the proposed constraint to operator scheduling, throughput increases up to 5.2 times compared to the naïve scheduling without the constraint.
RTRS
Authors: Qiao Ying , Han QiNan , Wang Hongan , Li Xiang , Zhong Kang , Zhang Keming , Liu Jian , Guo Anxiang
Published: July 2013

Event streaming processing (ESP) has been well investigated in recent years. Many approaches have been proposed on this aspect. However, none of them considers the timing constraints held by high-level reactive applications. In this paper, we propose a real-time reasoning system based on active rules (i.e., event-condition-action rules), called RTRS, to make automatic decisions about how to react to continuously arriving events (i.e., event streams) so that the deadlines of inference delay for rules can be met as much as possible. A series of simulations are conducted to evaluate the performance of RTRS. Simulation results show that the heuristic searching policy used by the inference algorithm -- RTEIA, which is the core of RTRS, effectively improves the number of times that rules are fired within the deadlines of their inference delay (NAFS).
Autologous minced muscle grafts: a tissue engineering therapy for the volumetric loss of skeletal muscle
Authors: Corona B. T. , Garg K. , Ward C. L. , McDaniel J. S. , Walters T. J. , Rathbone C. R.
Published: July 2013

Volumetric muscle loss (VML) results in a large void deficient in the requisite materials for regeneration for which there is no definitive clinical standard of care. Autologous minced muscle grafts (MG), which contain the essential components for muscle regeneration, may embody an ideal tissue engineering therapy for VML. The purpose of this study was to determine if orthotopic transplantation of MG acutely after VML in the tibialis anterior muscle of male Lewis rats promotes functional tissue regeneration. Herein we report that over the first 16 wk postinjury, MG transplantation 1) promotes remarkable regeneration of innervated muscle fibers within the defect area (i.e., de novo muscle fiber regeneration); 2) reduced evidence of chronic injury in the remaining muscle mass compared with nonrepaired muscles following VML (i.e., transplantation attenuated chronically upregulated transforming growth factor-β1 gene expression and the presence of centrally located nuclei in 30% of fibers observed in nonrepaired muscles); and 3) significantly improves net torque production (i.e., ∼55% of the functional deficit in nonrepaired muscles was restored). Additionally, voluntary wheel running was shown to reduce the heightened accumulation of extracellular matrix deposition observed within the regenerated tissue of MG-repaired sedentary rats 8 wk postinjury (collagen 1% area: sedentary vs. runner, ∼41 vs. 30%), which may have been the result of an augmented inflammatory response [i.e., M1 (CCR7) and M2 (CD163) macrophage expression was significantly greater in runner than sedentary MG-repaired muscles 2 wk postinjury]. These findings support further exploration of autologous minced MGs for the treatment of VML.
CXCR4-overexpressing bone marrow-derived mesenchymal stem cells improve repair of acute kidney injury
Authors: Liu Nanmei , Patzak Andreas , Zhang Jinyuan
Published: July 2013

Transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) can repair acute kidney injury (AKI), but with limited effect. We test the hypothesis that CXCR4 overexpression improves the repair ability of BMSCs and that this is related to increased homing of BMSCs and increased release of cytokines. Hypoxia/reoxygenation-pretreated renal tubular epithelial cells (HR-RTECs) were used. BMSCs, null-BMSCs, and CXCR4-BMSCs were cocultured with HR-RTECs. The number of migrating BMSCs was counted. Proliferating cell nuclear antigen (PCNA) expression, cell death, and expressions of cleaved caspase-3 and Bcl-2 in cocultured HR-RTECs were measured. Cytokeratin 18 (CK18) expression and cytokine secretions of the BMSCs cultured with HR-RTEC supernatant were detected. BMSC homing, renal function, proliferation, and cell death of tubular cells were assayed in the AKI mouse model. CXCR4-BMSCs showed a remarkable expression of CXCR4. Stromal cell-derived factor-1 in the HR-RTEC supernatant was increased. Migration of BMSCs was CXCR4-dependent. Proportions of CK18+ cells in BMSCs, null-BMSCs, and CXCR4-BMSCs showed no difference. However, CXCR4 overexpression in BMSCs stimulated secretion of bone morphogenetic protein-7, hepatocyte growth factor, and interleukin 10. The neutralizing anti-CXCR4 antibody AMD3100 abolished this. In cocultured HR-RTECs the proportions of PCNA+ cells and Bcl-2 expression were enhanced; however, the proportion of annexin V+ cells and expression of cleaved caspase-3 were reduced. The in vivo study showed increased homing of CXCR4-BMSCs in kidneys, which was associated with improved renal function, reduced acute tubular necrosis scoring, accelerated mitogenic response of tubular cells, and reduced tubular cell death. The enhanced homing and paracrine actions of BMSCs with CXCR4 overexpression suggest beneficial effects of such cells in BMSC-based therapy for AKI.
Oncothermia Basic Research at In Vivo Level: The First Results in Japan
Authors: Andocs G. , Okamoto Y. , Kawamoto K. , Osaki T. , Tsuka T. , Imagawa T. , Minami S. , Balogh L. , Meggyeshazi N. , Szasz O.
Published: July 2013

This paper summarizes the first results of oncothermia basic research conducted in Tottori University, Japan, and had two parts. In the first part C26 murine colorectal cancer model was investigated and oncothermia treatment induced histomorphological and some molecular changes which were examined. In the second study 9L rat glioma model was used to investigate the oncothermia treatment effects on tumor tissue oxygenization. Results of these investigations are very important in oncothermia research because this was the first time when independent research laboratory has repeated oncothermia experiments and proved the significant antitumoral and beneficial effects of oncothermia treatment.
Maternal Perception of Decreased Fetal Movement in One Twin: A Clue Leading to the Early Detection of Absent Variability due to Acute Twin-to-Twin Transfusion Syndrome
Authors: Suzuki Hirotada , Kuwata Tomoyuki , Ohkuchi Akihide , Yada Yukari , Matsubara Shigeki , Suzuki Mitsuaki
Published: July 2013

Decreased fetal movement (DFM) perceived by pregnant women sometimes indicates imminent fetal jeopardy. It is unknown whether this also holds true for twin pregnancy. A 27-year-old primiparous woman with monochorionic diamniotic (MD) pregnancy had a slight difference of amniotic fluid volume at 312/7weeks of gestation. DFM only in one twin at 314/7weeks of gestation prompted her to receive urgent consultation. Since cardiotocogram indicated absent variability of one twin, we performed Cesarean section. Male infants weighing 2060 g and 1578 g were delivered; hemoglobin was 20.7 versus 10.8 g/dL, respectively; cardiothoracic ratio was 70% versus 44%, respectively, indicating acute twin-to-twin transfusion syndrome (TTTS). The recipient infant had heart failure, which was still observed at 1 month postpartum. In conclusion, maternal perception of DFM indicated imminent fetal death or jeopardy caused by acute TTTS, suggesting that education regarding DFM for women with twin pregnancy may be clinically important.
Mechanical Properties of Lightweight Concrete Partition with a Core of Textile Waste
Authors: Aghaee Kamran , Foroughi Mohammad
Published: July 2013

This investigation is focused on bending experiment of some prismatic perlite lightweight concrete. In these samples, textile waste fibers are confined with textile mesh glass fiber and embedded in the central part of cubic lightweight concrete specimens. Bending experiments revealed that lightweight concrete panels with a core of textile waste fiber have less density than water and high energy absorption and ductility. Furthermore, these composite panels by having appropriate thermal insulation characteristics could be used for partitioning in the buildings.
Existence of Multiple Solutions for a p‐Kirchhoff Problem with Nonlinear Boundary Conditions
Authors: Xiu Zonghu , Chen Caisheng
Published: July 2013

The paper considers the existence of multiple solutions of the singular nonlocal elliptic problem   − M(∫Ω  | x|−ap | ∇u|p)div (|x|−ap | ∇u|p−2∇u) = λh(x) | u|r−2u, x ∈ Ω,  M(∫Ω  | x|−ap | ∇u|p) | x|−ap | ∇u|p−2 (∂u/∂ν) = g(x) | u|q−2u, on  ∂Ω, where 1 < (N + 1)/2 < p < N, a < (N − p)/p. By the variational method on the Nehari manifold, we prove that the problem has at least two positive solutions when some conditions are satisfied.
A Weighted Multiobjective Optimization Method for Mixed-Model Assembly Line Problem
Authors: Şeker Şükran , Özgürler Mesut , Tanyaş Mehmet
Published: July 2013

Mixed-model assembly line (MMAL) is a type of assembly line where several distinct models of a product are assembled. MMAL is applied in many industrial environments today because of its greater variety in demand. This paper considers the objective of minimizing the work overload (i.e., the line balancing problem) and station-to-station product flows. Generally, transportation time between stations are ignored in the literature. In this paper, Multiobjective Mixed-Integer Programming (MOMIP) model is presented to optimize these two criteria simultaneously. Also, this MOMIP model incorporates a practical constraint that allows to add parallel stations to assembly line to decrease higher station time. In the last section, MOMIP is applied to optimize the cycle time and transportation time simultaneously in mixed-model assembly line of a real consumer electronics firm in Turkey, and computational results are presented.
Emergent Intervention Criterias for Controlling Sever Bleeding after Percutaneous Nephrolithotomy
Authors: Oguz Ural , Resorlu Berkan , Bayindir Mirze , Sahin Tolga , Bozkurt Omer Faruk , Unsal Ali
Published: July 2013

Objectives. To determine when emergent intervention for bleeding after percutaneous nephrolithotomy (PCNL) is required. Methods. We reviewed analysis data of 850 patients who had undergone PCNL in our center. Blood transfusion was needed for 60 (7%) patients during and/or after surgery. We routinely performed followup of the urine output per hour, blood pressure, and hemoglobin levels after PCNL. Five (0.6%) of them had severe bleeding that emergent intervention was needed. Results. The mean age of the 5 patients who had emergent surgery due to severe bleeding was 42.2 (19–56) years. Mean duration of surgery was 44.75 (25–65) minutes. Mean stone size was 27 (15–38) mm. Mean decrease of hemoglobin was 4.8 (3.4–5.8) ng/dL, and unit of transfused blood was 4.4 (3–6). Mean blood pH was 7.21. There were metabolic acidosis and anuria/oliguria in all these patients. One of 5 patients suffered from cardiopulmonary arrest because of massive bleeding four hours after the PCNL, and despite cardiac resuscitation, he died. Hemorrhaging was controlled by open surgery in the other 4 patients. Two patients experienced cardiac arrest during the open surgery but they responded to cardiac resuscitation. There were no metabolic asidosis and anuria/oliguria, and bleeding was managed only with blood transfusion for the other 55 patients. Conclusion. Severe bleeding after PCNL is rare and can be mortal. If metabolic asidosis and anuria/oliguria accompanied the drop of hemoglobin, emergent surgical intervention should be performed because vascular collapse may follow, and it may be too difficult to stabilise the patient.
Development and Validation of High Performance Liquid Chromatography Method for Simultaneous Estimation of Ambroxol and Doxofylline in Their Combined Tablet Dosage Form
Authors: Singhal Neha , Gaur Kalpesh , Singh Anoop , Sekhawat Karni Singh
Published: July 2013

The present study described a new, simple, accurate, and precise high performance liquid chromatography method for the simultaneous determination of Ambroxol and Doxofylline in combined tablet dosage form. The chromatographic method was standardized using a BDS hypersil C18, 250 mm × 4.6 mm, 5 μ(particle size), Thermo scientific from Germany with isocratic conditions, and mobile phase containing potassium dihydrogen orthophosphate buffer-pH 4.5 (0.05 M KH2PO4): acetonitrile (60 : 40) at flow rate of 1 ml/min using UV detection at 254 nm. The retention times of Ambroxol and Doxofylline were 3.510 min and 7.247 min, respectively. The method was linear over the concentration range for Ambroxol 3.75–11.25 μg/mL and for Doxofylline 50-150 μg/mL. The recovery of Ambroxol and Doxofylline was found to be in the range of 99.42–101.18% and 99.37–100.28%, respectively. The validation of method was carried out using ICH guidelines. The described HPLC method was successfully employed for the analysis of pharmaceutical formulations containing combined dosage form.
A Survey on Content Adaptation Systems towards Energy Consumption Awareness
Authors: Ismail Mohd Norasri , Ibrahim Rosziati , Md Fudzee Mohd Farhan
Published: July 2013

The availability of heterogeneous devices has rapidly changed the way people access the World Wide Web that includes rich content applications such as video streaming, 3D games, video conferencing, and mobile TV. However, most of these devices' (i.e., mobile phone, PDA, smartphone, and tablet) capabilities differ in terms of built-in software and library (what they can display), display size (how the content appears), and battery supply (how long the content can be displayed). In order for the digital contents to fit the target device, content adaptation is required. There have been many projects focused on energy-aware-based content adaptation that have been designed with different goals and approaches. This paper reviews some of the representative content adaptation solutions that have been proposed during the last few years, in relation to energy consumption focusing on wireless multimedia streaming in mobile devices. Also, this paper categorizes the research work according to different classifications of multimedia content adaptation requirements. In addition, we discuss some energy-related challenges content adaptation systems.
Cutaneous Mucormycosis in a Diabetic Patient following Traditional Dressing
Authors: Ahmadinejad Zahra , Khazraiyan Hamideh , Ghanbari Fahime , Ahmadi Bahram , Gerami Shoar Mohsen
Published: July 2013

Cutaneous mucormycosis is a rare manifestation of an aggressive fungal infection. Early diagnosis and treatment are vitally important in improving outcome. We report an unusual case presenting with progressive necrotizing fasciitis due to mucormycosis following trauma and dressing by man-made herbal agents.
Dynamics of a Nonstandard Finite-Difference Scheme for a Limit Cycle Oscillator with Delayed Feedback
Authors: Wang Yuanyuan , Ding Xiaohua
Published: July 2013

We consider a complex autonomously driven single limit cycle oscillator with delayed feedback. The original model is translated to a two-dimensional system. Through a nonstandard finite-difference (NSFD) scheme we study the dynamics of this resulting system. The stability of the equilibrium of the model is investigated by analyzing the characteristic equation. In the two-dimensional discrete model, we find that there are stability switches on the time delay and Hopf bifurcation when the delay passes a sequence of critical values. Finally, computer simulations are performed to illustrate the theoretical results. And the results show that NSFD scheme is better than the Euler method.
Random Attractors for Stochastic Retarded Reaction-Diffusion Equations on Unbounded Domains
Authors: Ding Xiaoquan , Jiang Jifa
Published: July 2013

This paper is devoted to a stochastic retarded reaction-diffusion equation on alld-dimensional space with additive white noise. We first show that the stochastic retarded reaction-diffusion equation generates a random dynamical system by transforming this stochastic equation into a random one through a tempered stationary random homeomorphism. Then, we establish the existence of a random attractor for the random equation. And the existence of a random attractor for the stochastic equation follows from the conjugation relation between two random dynamical systems. The pullback asymptotic compactness is proved by uniform estimates on solutions for large space and time variables. These estimates are obtained by a cut-off technique.
A Purine Scaffold HSP90 Inhibitor BIIB021 Has Selective Activity against KSHV-Associated Primary Effusion Lymphoma and Blocks vFLIP K13-Induced NF-κB
Authors: Gopalakrishnan Ramakrishnan , Matta Hittu , Chaudhary Preet M.
Published: July 2013

Purpose: Kaposi sarcoma–associated herpes virus (KSHV)–associated primary effusion lymphomas (PEL) have extremely poor prognosis when treated with conventional chemotherapy. KSHV-encoded viral FLICE-inhibitory protein (vFLIP) K13 binds to the IkappaB kinase (IKK) complex to constitutively activate the NF-κB pathway, which has been shown to be essential for the survival and proliferation of PEL cells. The molecular chaperone HSP90 is a component of the IKK complex and is required for its activity.

Experimental Design: We have analyzed the effect of HSP90 inhibitors on the survival and proliferation of PEL cells and on the activity of the NF-κB pathway.

Results: We show that BIIB021, a purine scaffold–based orally administrable HSP90 inhibitor, shows preferential cytotoxicity toward PEL cells as compared with non-PEL cells. The cytotoxic effect of BIIB021 against PEL was associated with induction of cell-cycle arrest and apoptosis. BIIB021 blocked the expression of a number of cellular proteins involved in the regulation of cell cycle and apoptosis. BIIB021 also blocked constitutive NF-κB activity present in PEL cells, in part, by blocking the interaction of vFLIP K13 with the IKK complex subunits. In a xenograft model of PEL, BIIB021 significantly reduced tumor growth.

Conclusion: BIIB021 blocks constitutive NF-κB activity in PEL and shows preferential antitumor activity against PEL in vitro and in vivo. BIIB021 may be a promising agent for treatment of PEL. Clin Cancer Res; 19(18); 5016–26. ©2013 AACR.
Improved Glucose Tolerance after High-Load Strength Training in Patients Undergoing Dialysis
Authors: Molsted Stig , Harrison Adrian P. , Eidemak Inge , Dela Flemming , Andersen Jesper L.
Published: July 2013

Background/Aims: The aim of this controlled study was to investigate the effect of high-load strength training on glucose tolerance in patients undergoing dialysis. Methods: 23 patients treated by dialysis underwent a 16-week control period followed by 16 weeks of strength training three times a week. Muscle fiber size, composition and capillary density were analyzed in biopsies obtained in the vastus lateralis muscle. Glucose tolerance and the insulin response were measured by a 2-hour oral glucose tolerance test. Results: All outcome measures remained unchanged during the control period. After strength training the relative area of type 2X fibers was decreased. Muscle fiber size and capillary density remained unchanged. After the strength training, insulin concentrations were significantly lower in patients with impaired glucose tolerance or type 2 diabetes (n = 14) (fasting insulin from 68 ± 12 (46-96) to 54 ± 10 (37-77) pmol/l, p < 0.05, 2-hour insulin from 533 ± 104 (356-776) to 344 ± 68 (226-510) pmol/l, p < 0.05, total insulin area under the curve from 1,868 ± 334 (1,268-2,536) to 1,465 ± 222 (1,094-1,913), p < 0.05). Insulin concentrations were unchanged in patients with normal glucose tolerance (n = 9). Conclusion: The conducted strength training was associated with a significant improvement in glucose tolerance in patients with impaired glucose tolerance or type 2 diabetes undergoing dialysis. The effect was apparently not associated with muscle hypertrophy, whereas the muscle fiber type composition was changed.
Impact of aspirin dose on adenosine diphosphate-mediated platelet activities
Authors: Tello-Montoliu Antonio , Thano Estela , Rollini Fabiana , Patel Ronakkumar , Wilson Ryan E. , Muñiz-Lozano Ana , Franchi Francesco , Darlington Andrew , Desai Bhaloo , Guzman Luis A. , Bass Theodore A. , Angiolillo Dominick J.
Published: July 2013

Different aspirin dosing regimens have been suggested to impact outcomes when used in combination with adenosine diphosphate (ADP) P2Y12 receptor antagonists. Prior investigations have shown that not only aspirin, but also potent ADP P2Y12 receptor blockade can inhibit thromboxane A2-mediated platelet activation. The impact of aspirin dosing on ADP mediated platelet activities is unknown and represents the aim of this in vitro pilot pharmacodynamic (PD) investigation. Twenty-six patients with stable coronary artery disease on aspirin 81 mg/day and P2Y12 naïve were enrolled. PD assessments were performed at baseline, while patients were on 81 mg/day aspirin and after switching to 325 mg/day for 7 ± 2 days with and without escalating concentrations (vehicle, 1, 3, and 10 μM) of prasugrel’s active metabolite (P-AM). PD assays included flow cytometric assessment of VASP to define the platelet reactivity index (PRI) and the Multiplate Analyzer (MEA) using multiple agonists [ADP, ADP + prostaglandin (PGE1), arachidonic acid (AA), and collagen]. Escalating P-AM concentrations showed incremental platelet P2Y12 inhibition measured by VASP-PRI (p<0.001). However, there were no differences according to aspirin dosing regimen at any P-AM concentration (vehicle: p=0.899; 1 ïM: p=0.888; 3 ïM: p=0.524; 10 ïM: p=0.548). Similar findings were observed in purinergic markers assessed by MEA (ADP and ADP+PGE1). P-AM addition significantly reduced AA and collagen induced platelet aggregation (p<0.001 for all measures), irrespective of aspirin dose. In conclusion, aspirin dosing does not appear to affect PD measures of ADP-mediated platelet reactivity irrespective of the degree of P2Y12 receptor blockade. P2Y12 receptor blockade modulates platelet reactivity mediated by alternative activators.
Cultura afro-brasileira e diversidade
Authors: Arakaki Letícia Augusta
Published: July 2013

Este depoimento refere-se a minha experiência como aluna-professora a partir da participação de "espaço de criação" desenvolvido pela professora Nilce da Silva, cujo tema abordado foi a questão da cultura afro-brasileira e a diversidade. Relato aqui um pouco do trabalho que foi desenvolvido com as crianças relacionando a questão da diversidade etno-racial, cultural e social, visando a valorização da história, das contribuições africanas para a cultura brasileira e da identidade dos afrodescendentes.
Lusofonia: um pouco de história e poesia em sala de aula
Authors: Laudino Reinaldo Amaro
Published: July 2013

Este texto discute a diversidade cultural, sua prática no currículo escolar por meio de atividade desenvolvida com alunos em sala de aula, na cidade de São Paulo.
Conto angolano para crianças brasileiras
Authors: Cohn Anita , Cravo Júlia Chiaramonti
Published: July 2013

O depoimento abaixo é baseado em experiência em sala de aula sobre a temática da alfabetização no "mundo lusófono" e, a partir disso, trabalhamos a idéia da existência de outros países, os quais possuem diferenças e também semelhanças com o nosso.
Estudo sobre atitudes, valores e crenças a respeito do papel das famílias de alunos na fase inicial da escolarização no contexto da realização das "lições de casa": diálogo com a experiência quebequense
Authors: Silva Nilce da , Picchioni Marta Serra Young , Cascapera Marta Serra Young
Published: July 2013

O presente artigo apresenta o diálogo estabelecido entre o Centre de recherche et d'intervention sur la réussite scolaire da Universitè du Quebéc a Trois-Rivière (UQTr) por meio dos trabalhos da Profª. Drª. Rollande Deslandes e o grupo de pesquisa Estudos sobre populações migrantes no Brasil e no Mundo: o papel da instituição escolar numa perspectiva comparatista a partir de pesquisa qualitativa e quantitativa realizada sobre o tema "lição de casa" nos primeiros anos da escolarização em Trois-Rivières e na cidade de São Paulo.
Além da alfabetização: perspectivas históricas da experiência moçambicana de alfabetização de jovens e adultos
Authors: Quintella Siumara Silveira Melo
Published: July 2013

O presente artigo tem como objetivo levantar algumas reflexões sobre estudos de Alfabetização de jovens e adultos que compõem o manual elaborado por uma equipe de docentes¹ do Departamento de Educação da Universidade Eduardo Mondlane de Moçambique. A elaboração desse manual com a perspectiva de identificar o contexto histórico e educativo em que ocorre o processo de Alfabetização de Adultos em Moçambique apresenta um conjunto de estudos investigativos sobre a alfabetização de adultos no país, desde a época das primeiras campanhas até os dias atuais. Dessa forma, o foco das discussões deste texto é pautado apenas em duas, dentre as cinco categorias² propostas no manual, referentes à alfabetização de jovens e adultos no contexto educativo moçambicano. Essas discussões reflexivas estão ancoradas a partir de dados apresentados nesses estudos de alfabetização, demarcando histórias de lutas e conflitos e, ao mesmo tempo, apontando novos horizontes voltados para o acesso das classes populares à educação.
Modernidade X tradição, a questão dos rituais no processo de cura em Moçambique: ensaio
Authors: Costa Claudia Silvana da , Casseb Maria José Bueno
Published: July 2013

Este artigo se vincula a investigar o processo de modernização versus tradição, através do emprego de rituais na busca do processo de cura em Moçambique (África). Além disso, busca mapear a situação de alternativas de cura para doenças em Moçambique e mostrar a importância dos curandeiros neste processo.
A psicanálise na alfabetização
Authors: Borges Sonia
Published: July 2013

No campo dos estudos sobre a escrita, o reconhecimento da inscrição do processo de sua aquisição no campo da linguística e da psicanálise abre perspectivas para que as relações oralidade/escrita sejam consideradas segundo um novo prisma. Ao pesquisador fica aberta a possibilidade de descrever as transformações gráfico-textuais na escrita da criança, até então desconsiderada pelas teorias da alfabetização, enquanto efeito de um funcionamento linguístico-discursivo que as inclue. Neste funcionamento, linguagem oral e linguagem escrita emergem numa relação de mútua constituição.
A leitura de jornal e a exclusão de idosos
Authors: Arena Adriana Pastorello Buim
Published: July 2013

Este artigo tem como objetivo verificar se idosos, moradores em um asilo, da cidade de Marília, sentem necessidade da leitura em seu cotidiano. Participaram da pesquisa por amostragem, sete idosos, com idades variando de 74 a 99 anos. Os participantes foram divididos em dois grupos: grupo leitor e o grupo não-leitor. Responderam à entrevista semi-estruturada que resultou na possibilidade de discutir o conteúdo da educação de idosos que se encontram em asilos, suas necessidades e sua reintegração social.
A fala egocêntrica da criança de seis anos na construção coletiva da escrita
Authors: Cavaton Maria Fernanda Farah , Barbato Silviane
Published: July 2013

'Neste artigo apresentamos e analisamos os dados sobre os usos e as funções da fala egocêntrica de quatro crianças de seis anos nas suas produções gráficas livres: o desenho e as escritas iniciais. Nosso estudo foi desenvolvido na perspectiva da psicologia sociocultural na qual o desenvolvimento é construído dialogicamente durante atividades de ensinar e aprender em processos de letramento multimodal. Além disso, as interações e as resoluções de problemas em sala de aula envolveram práticas sociais baseadas nos modos de comunicação - oral, visual e gráfico. Analisamos quatro sessões gravadas em áudio e vídeo de sessenta minutos num primeiro ano do ensino fundamental. Das quatro sessões proporcionadas pela professora da classe, três foram de reconto de história infantil e uma de escrita livre. Utilizamos o episódio como unidade de análise. Aplicamos três categorias da literatura para analisar as falas egocêntricas e criamos uma quarta categoria para a situação específica encontrada em nossa pesquisa. Os resultados indicaram o uso da fala egocêntrica com a função organizadora do desenho e de soletração da escrita livre e o uso das falas egocêntricas com as seguintes funções geradoras de construção de conhecimento na intersubjetividade: a) comentário de outro social; b) comentário do próprio falante dirigido a outros sociais; c) falas egocêntricas em outros sociais; d) comentário de avaliação; e) falas egocêntricas de soletração "coletivizada"; f) comentário de concordância ou discordância
Perspectivas da economia solidária e da educação ambiental como práxis pedagógica no programa pescando letras
Authors: Araújo Sílvia Cordeiro de
Published: July 2013

Este trabalho discute as perspectivas de inserção transversal dos princípios e práticas da educação ambiental e da economia solidária nas ações de alfabetização de jovens e adultos pescadores artesanais a partir das proposições do programa Pescando Letras. Inicialmente aborda questões gerais da pesca artesanal no Brasil com base em revisão de bibliografia sobre o tema. Em seguida, relaciona os princípios e práticas da educação ambiental e da economia solidária ao contexto da pesca artesanal, concluindo que a educação, sob esse ponto de vista, pode contribuir significativamente para o desenvolvimento local sustentável das comunidades pesqueiras
Resenha de Liberdade para aprender
Authors: Rogers Carl Ransom
Published: July 2013

A obra "Liberdade para Aprender", de Carl R. Rogers, partiu de questionamentos a respeito do sistema educacional. Ele escreveu aos profissionais da educação numa tentativa de motivar o desejo de mudança e a realização de algo concreto. Para tanto, coloca à disposição tudo o que pôde ver de útil em sua própria experiência. Oferece exemplos que mostram como professores, trabalhando em níveis diferentes de ensino, descobriram maneiras de proporcionar liberdade para aprender, e apresenta consequências interessantes destes esforços. Aponta, ainda, atitudes a serem desenvolvidas por quem se interessa em ser "facilitador de aprendizagem", e recomenda métodos para desenvolver estas atitudes. Por fim, sugere um plano prático com vistas a mudanças revolucionárias no sistema de ensino.
Leitura: extensão de mundo
Authors: Lima Benevenuta Fátima de , Amorin Walquiria Therezinha dos Santos
Published: July 2013

A importância da leitura utilizada tanto na escola quando fora desse ambiente é destacada neste artigo, ao considerar-se que ela continua sendo um dos meios mais utilizados pelo homem para inserir-se no próprio mundo. Da leitura instintiva do universo até a leitura do mundo digitalizado, longo caminho foi percorrido. E para chegar aos dias de hoje, nos quais é grande a presença de artifícios implementados à comunicação, o homem exercitou o pensar e o agir, em uma conquista diária, com esforços incessantes na busca de novos conhecimentos. Como parte deste mundo que possibilita novas dimensões de vida, a escola deve buscar meios propícios para a inserção de seus professores e alunos no mundo digital, através da leitura de textos diversos, de maneira que o conhecimento desta nova ordem possibilite maior interação e, consequentemente, encontre estímulos reais para fazer a leitura atravessar fronteiras escolares e continuar vida a fora.
Cilostazol Ameliorates Warfarin-Induced Hemorrhagic Transformation After Cerebral Ischemia in Mice
Authors: Kitashoji Akira , Egashira Yusuke , Mishiro Keisuke , Suzuki Yukiya , Ito Hideki , Tsuruma Kazuhiro , Shimazawa Masamitsu , Hara Hideaki
Published: July 2013

Background and Purpose—

Although long-term treatment with the oral anticoagulant warfarin is widely used to prevent cardioembolic ischemic stroke, it has been reported that warfarin can exacerbate hemorrhagic transformation (HT) after cerebral ischemia. We investigated whether cilostazol, a phosphodiesterase-III inhibitor, suppressed the warfarin-induced HT after cerebral ischemia in mice.

Methods—

Male ddY mice were treated with oral warfarin before 3-hour middle cerebral artery occlusion followed by 21-hour reperfusion to induce HT. The duration of warfarin pretreatment was determined by measurement of prothrombin time-international normalized ratio value. Cilostazol or vehicle was administered by intraperitoneal injection immediately after reperfusion. The infarct volume, brain swelling, and brain hemoglobin content were evaluated at 24 hours after middle cerebral artery occlusion. We also evaluated the survival rate of each treated group for 7 days after surgery. To investigate the mechanism underlying cilostazol’s effects, the proteins involved in vascular endothelial integrity were investigated using Western blotting.

Results—

HT volume was exacerbated by warfarin treatment, and cilostazol (3 mg/kg, IP) suppressed this exacerbation (sham, mean±SD, 29.2±13.4 mg/dL; vehicle, 33.3±11.9 mg/dL; warfarin, 379.4±428.9 mg/dL; warfarin+cilostazol 1 mg/kg, 167.5±114.2 mg/dL; warfarin+cilostazol 3 mg/kg, 116.9±152.3 mg/dL). Furthermore, cilostazol improved survival rate and upregulated the expression of tight junction proteins and vascular endothelial cadherin.

Conclusions—

Cilostazol reduced the warfarin-related risk of HT after ischemia by protecting the vascular endothelial cells. This result suggested that cilostazol administration in patients with acute ischemic stroke might reduce HT.
New Ampharetidae (Polychaeta) from the deep Southern Ocean and shallow Patagonian waters
Authors: SCHÜLLER MYRIAM , JIRKOV IGOR A.
Published: July 2013

The terebellomorph Ampharetidae are among the most speciose polychaete families in Southern Ocean waters, especially in the deep sea. Because specimens are very fragile and species are often only present in low abundances, identification of species is challenging. In the present study the Ampharetidae of the expeditions ANDEEP I–III to the deep Weddell Sea and adjacent basins and samples from Patagonia were identified. In 574 individuals over 40 different species were found, of which only 13 could be assigned to described species without doubt. At least ten new species were found in the material of which eight are described herein, one of them belonging to a new genus. These are Abderos minotaurus gen.nov. n.sp., Amage micropaleata n.sp., Anobothrus paleaodiscus n.sp., Anobothrus wilhelmi n.sp., Noanelia orensanzi n.sp., and Zatsepinia antarctica n.sp. from ANDEEP-samples, and Amage septemdecima n.sp. and Anobothrus rubropaleatus n.sp. from the Knipovich expedition to Patagonian waters. In addition, diagnoses of all respective genera are given, as well as a key to all Anobothrus species recognized world-wide.
Editorial: Diversity of Southern Ocean deep-sea benthos between cosmopolitism and cryptic speciation: new species from the ANDEEP expeditions
Authors: SCHÜLLER MYRIAM , BRANDT ANGELIKA , EBBE BRIGITTE
Published: July 2013

The richness of life in parts of the earth that to us appear inhospitable and remote never fails to fascinate scientists and non-scientists alike. The largest ecosystem of the planet, the abyssal plains of the world ocean, makes up about 90 percent of the seafloor and thus nearly 78 percent of the Earth’s surface, yet only a minor fraction of this huge environment has been investigated. Authors have questioned repeatedly “how many species would live on earth and in the ocean” (Mora et al. 2011; May 2011), and recent estimations predict ~ 8.7 million (+/- 1.3 million SE) eukaryotic species globally, with 2.2 million of these being marine (Mora et al. 2011). To date, 91 % of all marine species still await description. Other authors concluded that marine biodiversity is grossly underestimated (Bouchet 2006) because so far, only one-third of all species descriptions concerns marine biota (Reaka-Kudla 1997; Groombridge & Jenkins 2000, Grassle 2001, Boltovskoy et al. 2005). We know that marine live thrives even in hadal trenches (Jamieson et al. 2009), that biogeographic ranges in the deep sea are dynamic (McClain & Mincks Hardy 2010) and that the origin of the modern deep-sea fauna is ancient (Thuy et al. 2012). For example, the origin of Isopoda dates back to Permo-Triassic times (232– 314 mya; Lins et al. 2012).