bluuebunny/crossref_metadata_2025 huggingface dataset:
Extracorporeal membrane oxygenation bridge to pediatric lung transplantation: Modern era analysis
Authors: Koh Wonshill , Zang Huaiyu , Ollberding Nicholas J. , Ziady Assem , Hayes Don
Published: July 2023

Background

Survival outcomes of children on extracorporeal membrane oxygenation (ECMO) at time of lung transplant (LTx) remain unclear.

Methods

Pediatric first‐time LTx recipients transplanted between January 2000 and December 2020 were identified in the United Network for Organ Sharing Registry to compare post‐transplant survival according to ECMO support at time of transplant. For a comprehensive analysis of the data, univariate analysis, multivariable Cox regression, and propensity score matching were performed.

Results

During the study period, 954 children under 18 years of age underwent LTx with 40 patients on ECMO. We did not identify a post‐LTx survival difference between patients receiving ECMO when compared to those that did not. A multivariable Cox regression model (Hazard ratio = 0.83; 95% confidence interval: 0.47, 1.45; p = .51) did not demonstrate an increased risk for death post‐LTx. Lastly, a propensity score matching analysis, retaining 33 ECMO and 33 non‐ECMO patients, further confirmed no post‐LTx survival difference comparing ECMO to no ECMO cohorts (Hazard ratio = 0.98; 95% confidence interval: 0.48, 2.00; p = .96).

Conclusions

In this contemporary cohort of children, the use of ECMO at the time of LTx did not negatively impact post‐transplant survival.
Evaluating the ending‐9 pricing strategy along the online shopping funnel
Authors: Chen Jialie
Published: July 2023

Ending‐9 prices are extremely popular among retailers, leveraging consumers’ perception biases. However, despite the popularity of this pricing strategy, understanding of its impact on online retailers is still limited. This is particularly true given the complexity of online retail where consumers need to traverse a shopping funnel, consisting of decisions with shopping cart and purchases. This study aims to answer the following three questions: First, do consumers hold a perception bias toward prices with online retailers? Second, whether and how effective is this bias in shifting consumer decisions? Third, what is an alternative pricing strategy for online retailers, to better leverage consumers’ perception bias? The results of a structural model reveal the impact of a perception bias on consumer decisions, toward both the shopping cart and purchases, at the online retailer. However, while ending‐9 prices exert a sizable impact on shopping cart additions (by nearly 20%), the impact on final purchases is marginal (by less than 4%). A possible reason could be that even if each individual product adopts its ending‐9 price, the cost of the shopping cart (which can involve multiple items) might still not preserve such a pricing structure. Consequently, a firm's ending‐9 pricing strategy for each individual product cannot effectively induce consumers’ perception bias toward the cost of the shopping cart, leading to very limited carryover in lifts from shopping cart additions to purchases. Motivated by these observations, we consider an alternative strategy in which the online retailer adjusts the cost of the shopping cart to end in 9, in addition to its current ending‐9 pricing strategy for individual products. By doing so, the retailer can induce perception bias for both the shopping cart and purchases. Our simulation results suggest that such a strategy not only promotes purchases (by 16%) but also helps reduce shopping cart abandonment (by 3%), the latter of which has become a critical concern for many online retailers.
White Skin, White Mask: Constructing Whiteness in Thomas Kyd's The Tragedy of Solyman and Perseda
Authors: Moosa Hassana
Published: July 2023

Criticism in early modern English drama has become increasingly attentive to how the ideologies of racial Whiteness are formed on the English stage. However, this scholarship has not yet considered how White supremacy is dramatically constructed against the male, Muslim, Ottoman, a figure who, I argue, would have been performed as phenotypically white on the English stage. By examining the racialisation of the Ottoman Soliman in Thomas Kyd's late sixteenth‐century play The Tragedy of Solyman and Perseda, this article illustrates how anxieties around the Muslim character's white sameness are negotiated by fashioning the Whiteness, or fairness, of the Greek, Christian Perseda as ‘natural’, while correspondingly framing Soliman's whiteness as ‘artificial’. Kyd renders Soliman's whiteness in this way by drawing on early modern English cosmetic language, customs, and debates. By turning to the male Muslim Ottoman figure, this study extends understandings of how racial Whiteness was shaped in early modern English culture, by illustrating how White supremacy is developed out of a Muslim‐Christian dichotomy and therefore in conjunction with Christian supremacy.
Soliton–mean field interaction in Korteweg–de Vries dispersive hydrodynamics
Authors: Ablowitz Mark J. , Cole Justin T. , El Gennady A. , Hoefer Mark A. , Luo Xu‐Dan
Published: July 2023

The mathematical description of localized solitons in the presence of large‐scale waves is a fundamental problem in nonlinear science, with applications in fluid dynamics, nonlinear optics, and condensed matter physics. Here, the evolution of a soliton as it interacts with a rarefaction wave or a dispersive shock wave, examples of slowly varying and rapidly oscillating dispersive mean fields, for the Korteweg–de Vries equation is studied. Step boundary conditions give rise to either a rarefaction wave (step up) or a dispersive shock wave (step down). When a soliton interacts with one of these mean fields, it can either transmit through (tunnel) or become embedded (trapped) inside, depending on its initial amplitude and position. A topical review of three separate analytical approaches is undertaken to describe these interactions. First, a basic soliton perturbation theory is introduced that is found to capture the solution dynamics for soliton–rarefaction wave interaction in the small dispersion limit. Next, multiphase Whitham modulation theory and its finite‐gap description are used to describe soliton–rarefaction wave and soliton–dispersive shock wave interactions. Lastly, a spectral description and an exact solution of the initial value problem is obtained through the inverse scattering transform. For transmitted solitons, far‐field asymptotics reveal the soliton phase shift through either type of wave mentioned above. In the trapped case, there is no proper eigenvalue in the spectral description, implying that the evolution does not involve a proper soliton solution. These approaches are consistent, agree with direct numerical simulation, and accurately describe different aspects of solitary wave–mean field interaction.
Variation in thermal stability of Ge1−xSnx films for infrared device applications
Authors: Lemire Amanda N. , Grossklaus Kevin A. , Vandervelde Thomas E.
Published: July 2023

We report on changes in Ge1−xSnx films (0.065 ≤ x ≤ 0.144) after short high-temperature anneals. Films were grown by molecular beam epitaxy on (001) Ge wafers, rapidly annealed, and characterized by x-ray diffraction, Raman spectroscopy, and optical microscopy. Sn segregated to the surface after a maximum temperature is inversely related to the Sn content. Lower content films showed little to no improvement in crystal quality below segregation temperatures, while higher content and partially relaxed films demonstrated improved uniformity for moderate annealing.
Scaling relations for sound scattering by a lattice of hard inclusions in a soft medium
Authors: Sharma Gyani Shankar , Skvortsov Alex , MacGillivray Ian , Kessissoglou Nicole
Published: July 2023

Soft elastic materials embedded with resonant inclusions are widely used as acoustic coatings for maritime applications. A versatile analytical framework for resonance scattering of sound waves in a soft material by a lattice of hard inclusions of complex shape is presented. Analogies from hydrodynamics and electrostatics are employed to derive universal scaling relations for a small number of well-known lumped parameters that map resonant scattering of a complex-shaped hard inclusion to that of a sphere. Multiple scattering of waves between inclusions in proximity is also considered. The problem is then treated using an effective medium theory, viz, a layer of hard inclusions is modeled as a homogenized layer with some effective properties. The acoustic performance of hard inclusions for a range of shapes with spheres of the same volume are compared. Results obtained using this approach are in good agreement with finite element simulations.
Maximum directivity of flanged open-ended waveguides
Authors: Dong Hao , Doc Jean-Baptiste , Félix Simon
Published: July 2023

Directional beams have extensive applications in communication and sound reproduction. This paper investigates the theoretical maximum directivity of infinitely flanged open-ended waveguides and the radiation pattern synthesis. We derive a rigorous solution for the maximum directivity factor of a flanged aperture with arbitrary shape by projecting its surface velocity on the waveguide modes, enabling the creation of a directional beam in any desired direction. We present case studies for a three-dimensional circular waveguide and a bidimensional waveguide. The theoretical beam that is obtained in a subspace spanned by all the propagating modes can then be synthesized by a group of incident modes or a point-source array within the waveguide. The optimality of the beam is demonstrated by comparing it with Gaussian shaded modes radiated from the waveguide. If the evanescent modes are taken into account, the maximum directivity factor increases with considerable loss to the radiation efficiency. Nevertheless, the optimum aperture velocity dominated by its evanescent components is capable of precise beam steering in extreme directions and could be useful for designing material-filled horns. Our work provides benchmark directivity factors and patterns for the practical design of horn antennas. In addition, we present a generalized form of Bouwkamp's impedance theorem.
Horizontal Gene Transfer and CRISPR Targeting Drive Phage-Bacterial Host Interactions and Coevolution in “Pink Berry” Marine Microbial Aggregates
Authors: Kosmopoulos James C. , Campbell Danielle E. , Whitaker Rachel J. , Wilbanks Elizabeth G.
Published: July 2023

Phages, which are viruses that infect bacteria, are important components of all microbial systems, in which they drive the turnover of organic matter by lysing host cells, facilitate horizontal gene transfer (HGT), and coevolve with their bacterial hosts. Bacteria resist phage infection, which is often costly or lethal, through a diversity of mechanisms.
In Silico
Evaluation of Variant Calling Methods for Bacterial Whole-Genome Sequencing Assays
Authors: Seah Yee Mey , Stewart Mary K. , Hoogestraat Daniel , Ryder Molly , Cookson Brad T. , Salipante Stephen J. , Hoffman Noah G.
Published: July 2023

Identification and analysis of clinically relevant strains of bacteria increasingly relies on whole-genome sequencing. The downstream bioinformatics steps necessary for calling variants from short-read sequences are well-established but seldom validated against haploid genomes.
Gut Colonization by ESBL-Producing Escherichia coli in Dogs Is Associated with a Distinct Microbiome and Resistome Composition
Authors: Stege Paul B. , Hordijk Joost , Sandholt Arnar K. S. , Zomer Aldert L. , Viveen Marco C. , Rogers Malbert R. C. , Salomons Moniek , Wagenaar Jaap A. , Mughini-Gras Lapo , Willems Rob J. L. , Paganelli Fernanda L.
Published: July 2023

The gut microbiome of humans and animals is an important source of multidrug resistant pathogens, including beta-lactamase-producing
Escherichia coli
(ESBL-EC). In this study, we assessed if the carriage of ESBL-EC in dogs was associated with changes in gut composition of bacteria and antimicrobial resistant genes (ARGs).
From Farm to Fork: Persistence of Clinically Relevant Multidrug-Resistant and Copper-Tolerant Klebsiella pneumoniae Long after Colistin Withdrawal in Poultry Production
Authors: Mourão Joana , Ribeiro-Almeida Marisa , Novais Carla , Magalhães Mafalda , Rebelo Andreia , Ribeiro Sofia , Peixe Luísa , Novais Ângela , Antunes Patrícia
Published: July 2023

The spread of bacteria resistant to last-resort antibiotics such as colistin throughout the food chain is a serious concern for public health. The poultry sector has responded by restricting colistin use and exploring alternative trace metals/copper feed supplements.
Fluid-fluxed melting in the Himalayan orogenic belt: Implications for the initiation of E-W extension in southern Tibet
Authors: Gao Li-E , Zeng Lingsen , Zhao Linghao , Yan Lilong , Hou Kejun , Wang Qian
Published: July 2023

The geochemistry of granite is largely controlled by physical and chemical parameters that are closely linked to tectonic processes in evolving orogenic belts. Therefore, temporal changes in the geochemical compositions of granites could be used to infer critical shifts in tectonic processes. The Himalayan leucogranites are crustal anatexis products, providing a case to formulate petrogenetic models for granites and test tectonic models. From west to east, in the High Himalaya and the Tethyan Himalaya, two groups of leucogranites are derived from fluid-absent melting (Group A) and fluid-fluxed melting of muscovite (Group B), respectively. In the Cona and Mount Everest areas, Group B granites crystallized at 26−10 Ma, and Group A granites formed at 19−13 Ma. Group B granites have higher CaO, Sr, Ba, Zr, Hf, Th, Sr/Y, Zr/Hf, and Th/U, and lower Rb, Nb, Ta, U, Rb/Sr, and 87Sr/86Sr than those in Group A granites. These geochemical differences highlight the role of deep-origin fluids and the dissolution control of the accessory phases on the geochemical compositions in silicic magma systems. Field and microstructural observations show that E-W extension occurred synchronously with the granite intrusion derived from fluid-fluxed melting. Elevated heat flow accompanying the E-W extension could dehydrate hydrous minerals and release fluids from deep-seated crust (e.g., Lesser Himalayan Sequence). Such fluids could flux and melt the metasedimentary rocks within the High Himalaya and produce Group B granites. Together with literature data, from the Lhasa terrane to the Himalayan belt, E-W extensions in Tibet may have initiated as early as 26 Ma.
What are the prognostic factors for the development of incontinence-associated dermatitis (IAD): a protocol for a systematic review and meta-analysis
Authors: Deprez Julie , Kottner Jan , Eilegård Wallin Alexandra , Ohde Nils , Bååth Carina , Hommel Ami , Hultin Lisa , Josefson Anna , Beeckman Dimitri
Published: July 2023

Introduction

Incontinence-associated dermatitis (IAD) is irritant contact dermatitis and skin damage associated with prolonged skin contact with urine and/or faeces. Identifying prognostic factors for the development of IAD may improve management, facilitate prevention and inform future research.

Methods and analysis

This protocol follows the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols. Prospective and retrospective observational studies or clinical trials in which prognostic factors associated with the development of IAD are described are eligible. There are no restrictions on study setting, time, language, participant characteristics or geographical regions. Reviews, editorials, commentaries, methodological articles, letters to the editor, cross-sectional and case–control studies, and case reports are excluded. MEDLINE, CINAHL, EMBASE and The Cochrane Library will be searched from inception until May 2023. Two independent reviewers will independently evaluate studies. The Quality in Prognostic Studies tool will be used to assess the risk of bias, and the Checklist for Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modelling Studies-Prognostic Factors checklist will be used for data extraction of the included studies. Separate analyses will be conducted for each identified prognostic factor, with adjusted and unadjusted estimated measures analysed separately. Evidence will be summarised with a meta-analysis when possible, and narratively otherwise. The Q and I2statistics will be calculated in order to quantify heterogeneity. The quality of the evidence obtained will be evaluated according to the Grades of Recommendation Assessment, Development and Evaluation guidance.

Ethics and dissemination

No ethical approval is needed since all data is already publicly accessible. The results of this work will be published in a peer-reviewed scientific journal.
Can baseline features predict a reduction in pain and disability following neck-specific exercise in people with chronic non-specific neck pain?: A systematic review and meta-analysis protocol
Authors: Chen Ziyan , Falla Deborah , Elgueta Cancino Edith , A Deane Janet
Published: July 2023

Introduction

Neck-specific exercises (NSEs) are commonly used for the treatment of chronic non-specific neck pain (CNSNP). However, it remains unclear whether baseline features can predict the response to neck-specific exercise (NSE) in people with CNSNP. This systematic review aims to assess whether baseline features such as age, gender, muscle activity, fatigability, endurance and fear of movement can predict pain and disability reduction following a NSE intervention.

Methods and analysis

This systematic review and meta-analysis will be reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Protocols guidelines checklist. The Web of Science, PubMed, Scopus, MEDLINE, Embase and CINAHL databases; key journals; and grey literature will be searched up until June 2023, including medical subject heading terms and keywords combinations. Included studies will investigate an association between the baseline features and pain and disability outcomes following NSE in people with CNSNP. Two independent reviewers will oversee the searching, screening, data extraction and assessment of risk of bias. The risk of bias will be assessed using the Risk Of Bias In Non-randomised Studies of Interventions (ROBINS-I) and Risk-Of-Bias tool for randomised trials 2 (ROB 2). The quality of evidence will be assessed using the Grading of Recommendations Assessment, Development and Evaluation approach (GRADE). Using standardised forms, details regarding study characteristics, baseline features (predictive factors), intervention, primary outcome and effect size (OR and 95% CI of each predictive factor and p value) will be extracted from included studies. Meta-analyses will be considered, if the studies are sufficiently homogeneous and if three or more studies investigate the same or comparable factors that predict the same response (pain intensity or disability). In the event that less than three studies investigated the same factors, a narrative synthesis will be conducted.

Ethics and dissemination

Ethical approval will not be required as this review will be based on published studies. The results of this study will be submitted to a peer-reviewed journal and presented at conferences.

PROSPERO registration number

CRD42023408332.
Barriers to implementation of dynamic reference points in fisheries management
Authors: Eddy Tyler D. , Duplisea Daniel , Robertson Matthew D. , Ruiz-Díaz Raquel , Solberg C. Abraham , Zhang Fan
Published: July 2023

Fish populations are dynamic; their productivity depends on the environment, predator and prey interactions, and fisheries harvest rates. Failure to account for these factors in fisheries science and management can lead to a misestimation of stock dynamics and productivity, resulting in overexploitation or forgone fisheries yield. Using an online survey, we asked fisheries scientists, industry stakeholders, Indigenous partners, and non-governmental organizations whether changing ecosystem productivity was a problem in their experience, how often dynamic approaches to fisheries reference points have been adopted, what methods had been used, and what fisheries they had been applied to. Changing fisheries or ecosystem productivity was reported as an issue by 96% of respondents; however, 74% of respondents said they had never seen dynamic reference points implemented, 16% said in very few instances, while 10% said frequently. The most common barriers to implementation of dynamic approaches in fisheries management were institutional inertia and uncertainty about whether a change in productivity was lasting. We discuss trade-offs between fisheries management performance and stability.
Leveraging augmentation techniques for tasks with unbalancedness within the financial domain: a two-level ensemble approach
Authors: Ranjbaran Golshid , Reforgiato Recupero Diego , Lombardo Gianfranco , Consoli Sergio
Published: July 2023

Modern financial markets produce massive datasets that need to be analysed using new modelling techniques like those from (deep) Machine Learning and Artificial Intelligence. The common goal of these techniques is to forecast the behaviour of the market, which can be translated into various classification tasks, such as, for instance, predicting the likelihood of companies’ bankruptcy or in fraud detection systems. However, it is often the case that real-world financial data are unbalanced, meaning that the classes’ distribution is not equally represented in such datasets. This gives the main issue since any Machine Learning model is trained according to the majority class mainly, leading to inaccurate predictions. In this paper, we explore different data augmentation techniques to deal with very unbalanced financial data. We consider a number of publicly available datasets, then apply state-of-the-art augmentation strategies to them, and finally evaluate the results for several Machine Learning models trained on the sampled data. The performance of the various approaches is evaluated according to their accuracy, micro, and macro F1 score, and finally by analyzing the precision and recall over the minority class. We show that a consistent and accurate improvement is achieved when data augmentation is employed. The obtained classification results look promising and indicate the efficiency of augmentation strategies on financial tasks. On the basis of these results, we present an approach focused on classification tasks within the financial domain that takes a dataset as input, identifies what kind of augmentation technique to use, and then applies an ensemble of all the augmentation techniques of the identified type to the input dataset along with an ensemble of different methods to tackle the underlying classification.
RNA polymerase is a unique Maxwell’s demon that converts its transcribing genetic information to free energy for its movement
Authors: Tsuruyama Tatsuaki
Published: July 2023

RNA polymerase (RNAP) catalyzes RNA synthesis from template DNA via translocation on the DNA. The experimental value of the free energy change required for RNAP translocation exhibits an unexplainable discrepancy. To address this, we propose a transcription system model based on information thermodynamics. The state function of RNAP was defined from its position on the template DNA (m), its migration direction (d), and the deoxyribonucleotide (dNTP) that it transcribes (N). Based on the state function, the free energy change in the RNAP translocation was defined as the sum of ΔGd in the movement fluctuation or the mutual entropy term kBTlogP(N) from the appearance probability P(N) of N to be transcribed by RNAP. In conclusion, a discrepancy in free energy change values is due to either ΔGd or kBTlogP(N) involvement. The discrepancy highlights that RNAP is a unique information-work converter or Maxwell’s demon that can feed back the obtained dNTP-type information into its self-movement along the DNA.
Forced convective power-law fluid flow through porous annular sector duct
Authors: Ahmed Farhan , Iqbal Mazhar
Published: July 2023

In this paper, we discuss the forced convective heat transfer of power-law fluid flow through porous annular sector duct by applying the Brinkman-extended Darcy flow model. A strongly implicit procedure (SIP) is utilized to solve the algebraic momentum and energy equations which was discretized by using the finite volume method (FVM). The effects of permeability factor and power-law index corresponding to the Brinkman-extended Darcy flow model and power-law fluid, respectively, on flow and heat transfer rate are carried out numerically and graphically against different values of parameters corresponding to geometrical configuration. In the pseudo-plastic fluids, a maximum decrease of more than [Formula: see text] has been observed in [Formula: see text], whereas maximum decrease in dilatant fluid is around [Formula: see text], when we increase the values of k. A decrease of 16.02% in Nu has been carried out in pseudo-plastic fluid, whereas unforeseen decrease in Nu has been observed in both Newtonian and dilatant fluids comparably pseudo-plastic fluid for particular values of k.
Localized Corrosion of 7xx.x Al Alloy Castings Grain-Refined with Al-5Ti-1B Master Alloy
Authors: Kramp J. , Shankar S. , Kish J. R.
Published: July 2023

The objective of this work was to determine the localized corrosion susceptibility of two artificially-aged 7xx.x Al alloy near net-shaped solidified castings (with a low and high Zn/Mg ratio) that were grain-refined with an Al-5Ti-1B master alloy to reduce hot tearing susceptibility. This was achieved using electrochemical polarization and bulk immersion measurements, coupled with electron microscopy techniques to reveal controlling microstructure aspects associated with corrosion. Both alloys, regardless of temper, exhibited the same corrosion mode: one that involved pit-like corrosion (selective grain attack) that occurred in sequence with the grain boundary region dissolving first, followed by the interdendritic region and then by the dendrite core of the equiaxed dendritic grain structure. The over-aged temper yielded the lowest corrosion susceptibility in terms of the depth of attack observed in cross-section. Of the various coarse eutectic phase particles present, Al2CuMg phase particles were particularly problematic for corrosion.
Optimizing Electrochemical Performance in Sodium-Ion Batteries using O3-type Na0.90Cu0.22Fe0.30Mn0.48O2 and Hard Carbon
Authors: Zhang Wenjuan , Zhang Yanli , Zhou Jiakun , Li Xiaoning , Zhou Wenzhang , Zhang Ding , Mao Jing , Dai Kehua
Published: July 2023

Sodium-ion batteries (SIBs) are being viewed as a prime alternative to lithium-ion batteries (LIBs) due to their resource availability, cost-effectiveness, safety, and superior power performance. Layered transition metal oxide cathode materials, in particular, have garnered interest for their high theoretical capacity and extended cycle life. This study focuses on the O3-type Na0.90Cu0.22Fe0.30Mn0.48O2(NCFMO), synthesized using the polyvinylpyrrolidone combustion method, showcasing notable specific capacity and capacity retention of over 80% after 200 cycles at 1C. Hard carbon has been identified as a potential candidate for commercialization among various anode materials, due to its high reversible capacity and stable structure. We assembled and evaluated a coin SIB full cell comprised of an NCFMO cathode and hard carbon anode (HC), which demonstrated optimal electrochemical performance at a positive-to-negative capacity ratio of 0.9. The study also explored the influence of the electrolyte on electrochemical performance, with NaClO4 (0.1 M NaClO4 in PC = 100 Vol% with 2.0%FEC) found to deliver the best results. Further, we assessed the heat generation characteristics of the NCFMO/HC full cell, revealing higher total heat generation during charging compared to discharging. This comprehensive study contributes significantly to the ongoing efforts towards commercialization of SIBs.
Screen-Printed Silver/Silver Chloride Electrodes Inhibit Alcohol Oxidase Activity
Authors: Lansdorp Bob M. , Lamberg Peter , Hamid Rashad
Published: July 2023

Silver/silver chloride (Ag/AgCl) is ubiquitous in the field of electrochemical biosensing due to its suitability as a reference electrode material. However, we recently discovered that screen-printed Ag/AgCl ink has a detrimental effect on Alcohol Oxidase enzyme stability. We performed an optical absorbance assay to isolate the interaction of enzyme and electrode to discover a surprisingly strong inhibition effect. The halftime of enzymatic activity was reduced from nearly 1 week in buffer to 10 h in the presence of the Ag/AgCl electrode. We expect this discovery to have broad implications on enzymatic biosensors that use Ag/AgCl as reference electrode material.
Table S1 from β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer
Authors: Suzuki Toshiyasu , Kilbey Anna , Casa-Rodríguez Nuria , Lawlor Amy , Georgakopoulou Anastasia , Hayman Hannah , Yin Swe Kyi Lai , Nordin Anna , Cantù Claudio , Vantourout Pierre , Ridgway Rachel A. , Byrne Ryan M. , Chen Lei , Verzi Michael P. , Gay David M. , Gil Vázquez Ester , Belnoue-Davis Hayley L. , Gilroy Kathryn , Køstner Anne Helene , Kersten Christian , Thuwajit Chanitra , Andersen Ditte K. , Wiesheu Robert , Jandke Anett , Blyth Karen , Roseweir Antonia K. , Leedham Simon J. , Dunne Philip D. , Edwards Joanne , Hayday Adrian , Sansom Owen J. , Coffelt Seth B.
Published: July 2023

Clinicopathological characteristics of colon cancer patient cohorts.
Synthesizing a Smarter CAR T Cell: Advanced Engineering of T-cell Immunotherapies
Authors: Zhu Iowis , Piraner Dan I. , Roybal Kole T.
Published: July 2023

The immune system includes an array of specialized cells that keep us healthy by responding to pathogenic cues. Investigations into the mechanisms behind immune cell behavior have led to the development of powerful immunotherapies, including chimeric-antigen receptor (CAR) T cells. Although CAR T cells have demonstrated efficacy in treating blood cancers, issues regarding their safety and potency have hindered the use of immunotherapies in a wider spectrum of diseases. Efforts to integrate developments in synthetic biology into immunotherapy have led to several advancements with the potential to expand the range of treatable diseases, fine-tune the desired immune response, and improve therapeutic cell potency. Here, we examine current synthetic biology advances that aim to improve on existing technologies and discuss the promise of the next generation of engineered immune cell therapies.
Supplementary Figure S6 from Immunologic assessment of tumors from a race-matched military cohort identifies mast cell depletion as a marker of prostate cancer progression
Authors: Schafer Cara C. , Jiang Jiji , Elsamanoudi Sally , Nousome Darryl , Young Denise Y , Song Yingjie , Sesterhenn Isabell A , Chesnut Gregory T , Tan Shyh-Han
Published: July 2023

Supplementary Figure S6 shows non-significant relative cell type scores by Gleason Sum.
Supplementary Figure S12 from Immunologic assessment of tumors from a race-matched military cohort identifies mast cell depletion as a marker of prostate cancer progression
Authors: Schafer Cara C. , Jiang Jiji , Elsamanoudi Sally , Nousome Darryl , Young Denise Y , Song Yingjie , Sesterhenn Isabell A , Chesnut Gregory T , Tan Shyh-Han
Published: July 2023

Supplementary Figure S12 shows Mast vs TILs scores plotted by race for Gleason Sum, GG, and Dx Age.
TABLE 3 from Phase Ib/II Study of a Liposomal Formulation of Eribulin (E7389-LF) plus Nivolumab in Patients with Advanced Solid Tumors: Results from Phase Ib
Authors: Ida Hanae , Shimizu Toshio , Nishino Makoto , Nakamura Yoshiaki , Yazaki Shu , Katsuya Yuki , Sato Jun , Koyama Takafumi , Iwasa Satoru , Sudo Kazuki , Kondo Shunsuke , Yonemori Kan , Shitara Kohei , Shiono Satoshi , Matsuoka Daiko , Yasuda Keisuke , Otake Yohei , Suzuki Takuya , Takase Takao , Takashima Shuya , Yamaguchi Kohei , Semba Taro , Yamamoto Noboru
Published: July 2023

Summary of tumor responses (per Investigator Review by RECIST v1.1)
Supplementary Methods 1 from Phase Ib/II Study of a Liposomal Formulation of Eribulin (E7389-LF) plus Nivolumab in Patients with Advanced Solid Tumors: Results from Phase Ib
Authors: Ida Hanae , Shimizu Toshio , Nishino Makoto , Nakamura Yoshiaki , Yazaki Shu , Katsuya Yuki , Sato Jun , Koyama Takafumi , Iwasa Satoru , Sudo Kazuki , Kondo Shunsuke , Yonemori Kan , Shitara Kohei , Shiono Satoshi , Matsuoka Daiko , Yasuda Keisuke , Otake Yohei , Suzuki Takuya , Takase Takao , Takashima Shuya , Yamaguchi Kohei , Semba Taro , Yamamoto Noboru
Published: July 2023

Supplementary Methods
Supplementary Figure 4 from Phase Ib/II Study of a Liposomal Formulation of Eribulin (E7389-LF) plus Nivolumab in Patients with Advanced Solid Tumors: Results from Phase Ib
Authors: Ida Hanae , Shimizu Toshio , Nishino Makoto , Nakamura Yoshiaki , Yazaki Shu , Katsuya Yuki , Sato Jun , Koyama Takafumi , Iwasa Satoru , Sudo Kazuki , Kondo Shunsuke , Yonemori Kan , Shitara Kohei , Shiono Satoshi , Matsuoka Daiko , Yasuda Keisuke , Otake Yohei , Suzuki Takuya , Takase Takao , Takashima Shuya , Yamaguchi Kohei , Semba Taro , Yamamoto Noboru
Published: July 2023

S4. Gene Expression Profiling in Biopsy Tissues
FIGURE 1 from Phase Ib/II Study of a Liposomal Formulation of Eribulin (E7389-LF) plus Nivolumab in Patients with Advanced Solid Tumors: Results from Phase Ib
Authors: Ida Hanae , Shimizu Toshio , Nishino Makoto , Nakamura Yoshiaki , Yazaki Shu , Katsuya Yuki , Sato Jun , Koyama Takafumi , Iwasa Satoru , Sudo Kazuki , Kondo Shunsuke , Yonemori Kan , Shitara Kohei , Shiono Satoshi , Matsuoka Daiko , Yasuda Keisuke , Otake Yohei , Suzuki Takuya , Takase Takao , Takashima Shuya , Yamaguchi Kohei , Semba Taro , Yamamoto Noboru
Published: July 2023

Maximum percentage change from baseline in sums of tumor diameters and best overall response per RECIST v1.1. E7389-LF, eribulin liposomal formulation; PD, progressive disease; PR, partial response; Q#W, every # weeks; RECIST v1.1, Response Evaluation Criteria In Solid Tumors, version 1.1; SD, stable disease.
Total life insurance: Logics of anticipatory control and actuarial governance in insurance technology
Authors: Sadowski Jathan
Published: July 2023

Calling attention to the growing intersection between the insurance and technology sectors—or ‘insurtech’—this article is intended as a bat signal for the interdisciplinary fields that have spent recent decades studying the explosion of digitization, datafication, smartification, automation, and so on. Many of the dynamics that attract people to researching technology are exemplified, often in exaggerated ways, by emerging applications in insurance, an industry that has broad material effects. Based on in-depth mixed-methods research into insurance technology, I have identified a set of interlocking logics that underly this regime of actuarial governance in society: ubiquitous intermediation, continuous interaction, total integration, hyper-personalization, actuarial discrimination, and dynamic reaction. Together these logics describe how enduring ambitions and existing capabilities are motivating the future of how insurers engage with customers, data, time, and value. This article surveys each logic, laying out a techno-political framework for how to orient critical analysis of developments in insurtech and where to direct future research on this growing industry. Ultimately, my goal is to advance our understanding how insurance—a powerful institution that is fundamental to the operations of modern society—continues to change, and what dynamics and imperatives, whose desires and interests are steering that change. The stuff of insurance is far too important to be left to the insurance industry.
Investigation on novel natural gas fueled homogeneous charge compression ignition engine based combined power and cooling system
Authors: Al-Mughanam Tawfiq , Khaliq Abdul
Published: July 2023

A significant part of energy of fuel supplied is lost in internal combustion engines in the form of atmospheric discharge of engine exhaust gases which are considered as a big source of engine inefficiency and formation of pollutant emissions. To address this issue, a bottoming cycle combining the transcritical CO2 (T-CO2) refrigeration cycle and the supercritical CO2 (sCO2) power cycle is employed, aiming to produce cooling for food preservation by utilizing the exhaust heat of homogeneous charge compression ignition (HCCI) engine powering the refrigerated truck. The operative variables and their effect on thermal and exergetic efficiency of HCCI engine and the combined system are investigated. At the base case operative conditions, the thermal and exergy efficiencies of natural gas fueled HCCI engine are improved significantly from 48.69% to 61.28% and from 41.14% to 42.79%, respectively, after employing the sCO2 powered T-CO2 refrigeration cycle. Promotion of equivalence ratio from 0.3 to 0.9 enhances the thermal and exergy efficiencies of HCCI engine from 47.44% to 49.54% and from 40.14% to 42.12%, respectively. Increasing of engine speed from 1400 r.p.m to 2200 r.p.m provides marginal improvement in HCCI engine efficiencies but the efficiencies of combined cycle are significantly improved from 57.67% to 65.18% and from 40.64% to 45.06%, respectively. Finally, exergy analysis applied to determine the sources of non-idealities within the system revealed that out 361 kW (100%) fuel exergy supplied to the system, HCCI engine destroys 93.31 kW (25.85%), catalytic convertor destroys15.49 kW (4.29%), and the in-cylinder heat transfer losses and system exhaust losses are found as 35.72 kW (9.91%) and 16.61 kW (4.61%), respectively.
Inhibition of Tumor Glycolysis by Umbelliferone and its Binding to Glycolytic Proteins
Authors: Peng Kangbo , Wang Yingxiao , Lei Xia , Wang Yang , Yang Yanfang , Wu Song-Tao
Published: July 2023

Background and Objectives

Both primary and secondary cancers require the involvement of glycolytic pathways. Cancer cell proliferation leads to the upregulation of glycolysis, which results in increased glucose consumption. For demonstrating that umbelliferone can effectively bind to several proteins involved in the glycolytic pathway, thereby inhibiting glycolysis and reducing cancer cell proliferation.

Materials and Methods

This study uses transcriptomics, network pharmacology, and molecular docking to predict the potential targets and possible pathways of umbelliferone against cancer and microscale thermophoresis (MST) to detect the affinity between umbelliferone and potential targets.

Results

Transcriptomic analysis revealed that differentially expressed genes were primarily associated with glycolytic and other metabolic pathways and proteins. According to network pharmacology and molecular docking results, glycolysis-related proteins such as glucose-6-phosphate isomerase (GPI), glycerol-3-phosphate dehydrogenase, mitochondrial (GPD2), phosphoglycerate kinase 2 (PGK2), and heat shock protein HSP-90 alpha (Hsp90AA1) are potential targets of umbelliferone against tumors. MST confirmed that umbelliferous lactone binds strongly to GPI, GPD2, and PGK2 but not to Hsp90AA1.

Conclusion

By binding to the glycolysis-related proteins such as GPI, GPD2, and PGK2, umbelliferone acts as an anti-tumor agent by inhibiting glycolysis, cutting off the energy supply to tumor tissue, and reducing tumor growth. It was suggested that umbelliferone might be a brand-new tumor glycolysis inhibitor and that these glycolysis-related proteins might be potential new targets for cancer therapy. This finding helped to establish a solid foundation for the anti-cancer action of umbelliferone.
Control design-oriented modeling and µ-synthesis-based robust multivariate control of a turbocharged natural gas genset engine
Authors: Qiu Weijin , Rayasam Sree Harsha , Shaver Gregory M , Rimstidt Ted G , Van Alstine Daniel G
Published: July 2023

This paper describes a comprehensive framework for the development and validation of a model-based robust multivariate controller, which is used to regulate the gas exchange processes of an advanced turbocharged natural gas genset engine. The natural gas genset engine involved in this study features a multi-input and multi-output structure and is highly nonlinear, making it a challenge for which to design a controller. A control design-oriented model describing the dynamics of the studied engine is first developed and validated, using modeling techniques commonly employed for modeling of turbocharged engines. A novel robust model-based multivariate controller is then synthesized to incorporate the significant coupling between the engine actuators (throttle valve, bypass valve, and fuel valve) and the desired control objectives (engine speed, throttle differential pressure, and air-to-fuel ratio). To verify the effectiveness of the synthesized controller, it is compared to a benchmark production controller using an experimentally-validated simulation model. Simulation results indicate the merits of the synthesized robust multivariate controller in terms of better tracking performance (robust multivariate controller reduces steady-state error of engine speed, throttle differential pressure, and AFR at most by 100%, 58.9%, and 100% respectively, compared to benchmark production controller), faster transient response (robust multivariate controller reduces settling time of engine speed, throttle differential pressure, and AFR at most by 74.5%, 47.8%, and 71.2% respectively, compared to the benchmark production controller), and finer coordination among multiple interacted actuators when faced with multifacted control objectives.
Attractiveness Differentially Affects Direct Versus Indirect Face Evaluations in Two Cultures
Authors: Cassidy Brittany S. , Saribay S. Adil , Yüksel Hüseyin , Kleisner Karel
Published: July 2023

Although decades of research have identified facial features relating to people's evaluations of faces, specific features have largely been examined in isolation from each other. Recent work shows that considering the relative importance of these features in face evaluations is important to test theoretical assumptions of impression formation. Here, we examined how two facial features of evolutionary interest, facial attractiveness and facial-width-to-height ratio (FWHR), relate to evaluations of faces across two cultures. Because face evaluations are typically directly measured via self-reports, we also examined whether these features exert differential effects on both direct and indirect face evaluations. Evaluations of standardized photos naturally varying in facial attractiveness and FWHR were collected using the Affect Misattribution Procedure in the United States and Turkey. When their relative contributions were considered in the same model, facial attractiveness, but not FWHR, related to face evaluations across cultures. This positive attractiveness effect was stronger for direct versus indirect evaluations across cultures. These findings highlight the importance of considering the relative contributions of facial features to evaluations across cultures and suggest a culturally invariant role of attractiveness when intentionally evaluating faces.
Study on predictability of ocean wave fields based on marine radar measurement data
Authors: Lee Jae-Hoon , Nam Yoon-Seo , Liu Yuming , Yang Heesuk
Published: July 2023

In this study, the predictability of ocean wave fields is considered based on marine radar measurement data. Phase-resolved components obtained by applying 3D FFT-based reconstruction to a sequence of radar images are utilized for wave field prediction, and two different prediction approaches are introduced: (i) snapshot data-based prediction through the adjustment of the frequency and phase of each component, and (ii) spatiotemporal data-based prediction through the data assimilation for reconstructed wave fields. Furthermore, the time evolution of a predictable zone is derived for different shapes of measurement domains including rectangular and ring-shaped domains. To validate the proposed wave propagation modeling method, numerical simulations are conducted on synthetic radar images created by reflecting geometrical shadowing effects, and the prediction accuracy is examined in relation to the derived predictable zone. Lastly, the forecasting performance, which is represented by the predictable time range at a radar location, is discussed with respect to the prediction techniques, specifications of the reconstruction domain, and moving measurements.
Posttraumatic Stress Disorder Symptoms and Sleep Disturbances Among Asian Indians: A Systematic Review
Authors: Contractor Ateka A. , Almeida Isamar M. , Fentem Andrea , Griffith Elizabeth L. , Kaur Gurleen , Slavish Danica C.
Published: July 2023

Substantial comorbidity exists between posttraumatic stress disorder and sleep disturbances/disorders. Such comorbidities are understudied in minority groups, including Asian Indians residing in countries outside India. Thus, we synthesized the existing literature specific to this group of Asian Indians to determine (a) prevalence estimates of posttraumatic stress disorder (PTSD) and sleep disturbances/disorders; and (b) PTSD-sleep comorbidity estimates. For this systematic review, we searched four databases (PubMed, PsycInfo, PTSDpubs, Web of Science) using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Of 3,796 screened articles, 9 articles (10 studies) met inclusion criteria. Study sample sizes ranged from 11 to 2,112 Asian Indians; studies were conducted in Singapore or Malaysia. No reviewed study examined PTSD. All studies examined sleep disturbances/disorders among Asian Indians; prevalence estimates were: 8.3% to 70.4% for short sleep duration, 2.0% to 22.9% for long sleep duration, 25.9% to 56.3% for poor sleep quality, 3.4% to 67.5% for insomnia diagnosis or probable insomnia, 7.7% for excessive daytime sleepiness, 3.8% to 54.6% for obstructive sleep apnea (OSA) diagnosis or high OSA risk, and 5.1% to 11.1% for sleep-disordered breathing. Specific to Asian Indians residing in countries outside India, this review advances PTSD-sleep literature by (a) suggesting substantial prevalence of sleep disturbances/disorders; (b) highlighting the need for culturally relevant sleep interventions; and (c) highlighting research gaps (e.g., no PTSD-focused research).
A roadmap for research in post-stroke fatigue: Consensus-based core recommendations from the third Stroke Recovery and Rehabilitation Roundtable
Authors: English Coralie , Simpson Dawn B , Billinger Sandra A , Churilov Leonid , Coupland Kirsten G , Drummond Avril , Kuppuswamy Annapoorna , Kutlubaev Mansur A , Lerdal Anners , Mahmood Amreen , Moseley G Lorimer , Pittman Quentin J , Riley Ellyn A , Sutherland Brad A , Wong Connie HY , Corbett Dale , Mead Gillian
Published: July 2023

Rationale:

Fatigue affects almost half of all people living with stroke. Stroke survivors rank understanding fatigue and how to reduce it as one of the highest research priorities.

Methods:

We convened an interdisciplinary, international group of clinical and pre-clinical researchers and lived experience experts. We identified four priority areas: (1) best measurement tools for research, (2) clinical identification of fatigue and potentially modifiable causes, (3) promising interventions and recommendations for future trials, and (4) possible biological mechanisms of fatigue. Cross-cutting themes were aphasia and the voice of people with lived experience. Working parties were formed and structured consensus building processes were followed.

Results:

We present 20 recommendations covering outcome measures for research, development, and testing of new interventions and priority areas for future research on the biology of post-stroke fatigue. We developed and recommend the use of the Stroke Fatigue Clinical Assessment Tool.

Conclusions:

By synthesizing current knowledge in post-stroke fatigue across clinical and pre-clinical fields, our work provides a roadmap for future research into post-stroke fatigue.