bluuebunny/crossref_metadata_2025 huggingface dataset:
The histamine H3R antagonist DL77 attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism
Authors: Eissa Nermin , Jayaprakash Petrilla , Azimullah Sheikh , Ojha Shreesh K. , Al-Houqani Mohammed , Jalal Fakhreya Y. , Łażewska Dorota , Kieć-Kononowicz Katarzyna , Sadek Bassem
Published: August 2018

Autistic spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairment in social communication and restricted/repetitive behavior patterns or interests. Antagonists targeting histamine H3 receptor (H3R) are considered potential therapeutic agents for the therapeutic management of different brain disorders, e.g., cognitive impairments. Therefore, the effects of subchronic treatment with the potent and selective H3R antagonist DL77 (5, 10, or 15 mg/kg, i.p.) on sociability, social novelty, anxiety, and aggressive/repetitive behavior in male Tuck-Ordinary (TO) mice with ASD-like behaviors induced by prenatal exposure to valproic acid (VPA, 500 mg/kg, i.p.) were evaluated using the three-chamber test (TCT), marble burying test (MBT), nestlet shredding test (NST), and elevated plus maze (EPM) test. The results showed that VPA-exposed mice exhibited significantly lower sociability and social novelty preference compared to VPA-exposed mice that were pretreated with DL77 (10 or 15 mg/kg, i.p.). VPA-exposed mice presented a significantly higher percentage of buried marbles in MBT and shredded nestlet significantly more in NST compared to the control groups. However, VPA-exposed animals pretreated with DL77 (10 or 15 mg/kg, i.p.) buried a reduced percentage of marbles in MBT and presented a significantly lower percentage of shredding behavior in NST. On the other hand, pretreatment with DL77 (5, 10, or 15 mg/kg, i.p.) failed to restore the disturbed anxiety levels and hyperactivity observed in VPA-exposed animals in EPM, whereas the reference drug donepezil (DOZ, 1 mg/kg, i.p.) significantly palliated the anxiety and reduced the hyperactivity measures of VPA-exposed mice. Furthermore, pretreatment with DL77 (10 or 15 mg/kg, i.p.) modulated oxidative stress status by increasing GSH and decreasing MDA, and it attenuated the proinflammatory cytokines IL-1β, IL-6 and TNF-α exacerbated by lipopolysaccharide (LPS) challenge, in VPA-exposed mouse brain tissue. Taken together, these results provide evidence that modulation of brain histaminergic neurotransmission, such as by subchronic administration of the H3R antagonist DL77, may serve as an effective pharmacological therapeutic target to rescue ASD-like behaviors in VPA-exposed animals, although further investigations are necessary to corroborate and expand these initial data.
Reproductive factors and molecular subtypes of breast cancer among premenopausal women in Latin America: the PRECAMA study
Authors: Romieu Isabelle , Biessy Carine , Carayol Marion , His Mathilde , Torres-Mejía Gabriela , Ángeles-Llerenas Angélica , Sánchez Gloria Inés , Jaramillo Roberto , Navarro Edgar , Porras Carolina , Ocampo Rebecca , Rodriguez Ana Cecilia , Garmendia Maria Luisa , Bustamante Eva , Olivier Magali , Porter Peggy , Rinaldi Sabina ,   On behalf of the PRECAMA team, Tejeda Jenny , Gaete Fancy , Soto Jose , Angel Gonzalo Alberto , Ossa Carlos Andres , Arias William H. , Bedoya Gabriel , Borrero Mauricio , Cock-Rada Alicia , Díaz-Yunez Israel , Echeverri Carolina , Herazo Fernando , Hernández Angel , Cortes Yorlany Rodas , Cortes Bernal , Gonzalez Paula , Guillen Diego
Published: August 2018

Etiological differences among breast cancer (BC) subtypes have not been clearly established, especially among young women in Latin America. This study examined the relationship between reproductive factors and BC subtypes among 288 BC cases (20–45 years) and population-based matched controls in four Latin American countries. Immunohistochemistry was determined centrally. Associations between BC and reproductive factors were determined. Older age at first full-term pregnancy (FFTP) (Odds Ratio (OR) = 1.11; 95% Confidence Interval (CI), 1.04–1.19 per year), longer time between menarche and FFTP (OR = 1.12; 95%CI: 1.04–1.20 per year), and older age at last pregnancy (OR = 1.10; 95%CI, 1.02–1.19 per year) were associated with an increased risk of estrogen receptor positive (ER+) tumors (n = 122). Ever pregnant (OR = 0.35; 95%CI, 0.13–0.96), number of childbirths (OR = 0.64; 95%CI, 0.47–0.87 per child), time since last birth (OR = 0.92; 95%CI, 0.85–0.99 per year), and history of breastfeeding (OR = 0.23; 95%CI, 0.09–0.58) were inversely associated with the risk of ER+ tumor. Older age at menarche (OR = 0.63; 95%CI, 0.45–0.89 per year) and longer duration of breastfeeding (OR = 0.97; 95%CI, 0.94–1.01 per month) were inversely associated with estrogen receptor negative (ER-) tumors (n = 48). Reproductive factors may be differentially associated with BC subtypes in young Latin American women.
Structural, electrical and magnetic properties of Nd – A – CoO3 (A = Sr, Ca) Perovskite Powders by Mechanical Alloying
Authors: Kursun Celal , Gogebakan Musa , Uludag Esra , Bozgeyik Mehmet S. , Uludag Fatih Samil
Published: August 2018

In this work, NdCoO3 (NCO), Nd0.8Sr0.2CoO3 (NSCO) and Nd0.9Ca0.1CoO3 (NCCO) perovskite cobaltites were synthesised by mechanical alloying method. Structural evolutions, magnetic and electrical properties of these perovskite were systematically examined through X-ray diffraction (XRD), scanning electron microscopy with energy-dispersive X-ray detection (SEM-EDX), transmission electron microscopy (TEM), differential scanning calorimetry (DSC), vibration sample magnetometer (VSM) and impedance analyser (IA). The XRD and SEM results revealed that the microstructure of the perovskite materials changed during mechanical alloying. The average crystallite size of the perovskite materials was calculated by Debye Scherrer equation and was confirmed by TEM, and it was determined ~19 nm. From the VSM results, the all perovskites had soft ferromagnetic properties. IA measurements showed that relatively dielectric constants of the perovskites decreased with increasing frequency. Therefore, for the first time, nanostructured NCO, NSCO and NCCO perovskites exhibiting good properties were produced in only two steps which are milling and heating.
Elucidating the transactivation domain of the pleiotropic transcription factor Myrf
Authors: Choi Jin-ok , Fan Chuandong , Kim Dongkyeong , Sharif Mohamed , An Hongjoo , Park Yungki
Published: August 2018

Myrf is a newly discovered membrane-bound transcription factor that plays an essential role in as diverse organisms as human, worm, and slime mold. Myrf is generated as a type-II membrane protein in the endoplasmic reticulum (ER). It forms homo-oligomers to undergo auto-cleavage that releases Myrf N-terminal fragment from the ER membrane as a homo-trimer. The homo-trimer of Myrf N-terminal fragments enters the nucleus and binds the Myrf motif to activate transcription. Despite its prominent role as a transcriptional activator, little is known about the transactivation domain of Myrf. Here, we report that the N-terminal-most (NTM) domain of Myrf is required for transcriptional activity and, when fused to a Gal4 fragment, enables it to activate transcription. The transactivation function of the NTM domain did not require homo-trimerization. We also discovered that the NTM domain can be sumoylated at three lysine residues (K123, K208, and K276), with K276 serving as the main acceptor. K276 sumoylation repressed the transactivation function of the NTM domain without affecting the stability or nuclear localization of Myrf N-terminal fragment. In sum, this study identifies the NTM domain as the transactivation domain of Myrf and the potential regulatory impact of its K276 sumoylation.
Nomogram based on albumin and neutrophil-to-lymphocyte ratio for predicting the prognosis of patients with oral cavity squamous cell carcinoma
Authors: Kao Huang-Kai , Löfstrand Jonas , Loh Charles Yuen-Yung , Lao William Wei-Kai , Yi Jui-Shan , Chang Yu-Liang , Chang Kai-Ping
Published: August 2018

Increasing evidence indicates that inflammation plays a crucial role in cancer development. A novel scoring system based on albumin and the neutrophil-to-lymphocyte ratio (NLR) was developed and incorporated into a nomogram to create a more accurate prognostic tool for oral cavity squamous cell carcinoma (OSCC) patients. A retrospective review was performed on 613 consecutive patients undergoing ablative surgery for OSCC between September 2005 and December 2014. NLR and albumin were determined and used to calculate an albumin/NLR score (ANS). The nomogram was based on the ANS and several clinicopathological manifestations, and its accuracy was determined by the concordance index (c-index). A high ANS was significantly associated with aggressive tumor behaviors, such as T status, overall stage, extranodal extension, perineural invasion, tumor depth, and decreased overall survival (OS). Multivariate analysis indicated that age, overall stage, extranodal extension, and ANS were independent factors for OS. The c-index for OS prognosis was 0.750 using this nomogram compared to 0.688 using TNM staging alone. The prognostic accuracy for OS in OSCC patients can be significantly improved using a nomogram that incorporates the novel ANS and other clinicopathological variables.
General Anesthesia with the Use of SUPREME Laryngeal Mask Airway for Emergency Cesarean delivery: A Retrospective Analysis of 1039 Parturients
Authors: Fang Xiaobin , Xiao Quansheng , Xie Qianling , Liao Ren , Zhu Tao , Li Shiyang , Bo Zhenyan
Published: August 2018

In comparison to elective cesarean delivery, emergency cesarean delivery under endotracheal intubation is associated with higher risk of life-threatening airway problems. In this retrospective study, we evaluate the efficacy and feasibility of using SUPREME laryngeal mask airway (SLMA) in emergency cesarean delivery under general anesthesia (GA). The study included a total of 1039 paturients undergoing emergency cesarean delivery under GA with SLMA from January 2015 to December 2015 at Quanzhou Children’s and Women’s Hospital. Outcome measures included incidence of the adverse events related to using SLMA, maternal mortality, and neonatal outcomes. Briefly, no aspiration or regurgitation was noticed; the first attempt was successful in all but 2 subjects, both because of incorrect location, one was detected by decreasing oxygenation and the other by high airway pressure, the second attempt was successful in both cases. No subject was switched to endotracheal intubation. No laryngospasm or bronchospasm was detected. No maternal death occurred. There were 1139 neonates (including 944 single birth, 92 twins, 3 triplets) in this study, 5-min Apgar score was 7–10 in 1092 (96.72%) neonates. Thirty-seven (3.28%) neonates received endotracheal intubation. In conclusion, this retrospective study showed that the SLMA was used successfully in 1039 patients undergoing emergent cesarean delivery without any major complications. Vigilant attention by attending anesthesiologists is warranted.
Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging
Authors: Liu Hong-Wen , Chen Lanlan , Xu Chengyan , Li Zhe , Zhang Haiyang , Zhang Xiao-Bing , Tan Weihong
Published: August 2018

An overview of recent advances in small-molecule enzymatic fluorescent probes for cancer imaging, including design strategies and cancer imaging applications.
A colorimetric chemosensor for heptanal with selectivity over formaldehyde and acetaldehyde through synergistic interaction of hydrophobic interactions and oxime formation
Authors: Oh Jinyoung , Kang Seungyoon , Lee Cheol Gyu , Han Min Su
Published: August 2018

Hydroxylamine-functionalized polydiacetylene was evaluated as a heptanal chemosensor with selectivity over formaldehyde and acetaldehyde.
A sensitive electrochemical aptasensor for detection of Aflatoxin B2 based on a polyacrylamide/phytic acid/polydopamine hydrogel modified screen printed carbon electrode
Authors: Geleta Girma Selale , Zhao Zhen , Wang Zhenxin
Published: August 2018

A cost effective, environmentally friendly and disposable PAM/PA/PDA hydrogel based electrochemical aptasensor has been developed for sensitive and selective detection of Aflatoxin B2.
Triply green polyaniline: UV irradiation-induced synthesis of a highly porous PANI/TiO2 composite and its application in dye removal
Authors: Cionti Carolina , Della Pina Cristina , Meroni Daniela , Falletta Ermelinda , Ardizzone Silvia
Published: August 2018

An eco-friendly synthesis of polyaniline/TiO2 composites with good crystallinity and tailored morphology is reported for dye removal from an aqueous matrix.
The Strecker reaction coupled to Viedma ripening: a simple route to highly hindered enantiomerically pure amino acids
Authors: Baglai Iaroslav , Leeman Michel , Wurst Klaus , Kaptein Bernard , Kellogg Richard M. , Noorduin Willem L.
Published: August 2018

We introduce a methodology based on a combination of the classical Strecker reaction, simple condensation and Viedma ripening, which allows absolute asymmetric synthesis of highly sterically hindered α-amino acids. As proof-of-principle, enantiomerically pure unnatural α-amino acids tert-leucine and α-(1-adamantyl)glycine have been obtained.
Atomistic dewetting mechanics of Wenzel and monostable Cassie–Baxter states
Authors: Xiao Senbo , Zhang Zhiliang , He Jianying
Published: August 2018

Pulling force was used to dewet water droplets in the Wenzel and the monostable Cassie–Baxter wetting states. The nanomechanics of water adhesion on nanopillars and flat surfaces in the dynamic process of dewetting was revealed. The details of effects from nanopillars and surface energy on water dewetting were clarified.
The oxygen reduction reaction on [NiFe] hydrogenases
Authors: Qiu Siyao , Olsen Seth , MacFarlane Douglas R. , Sun Chenghua
Published: August 2018

Oxygen tolerance capacity is critical for hydrogen oxidation/evolution catalysts.
The ultimate switching speed limit of redox-based resistive switching devices
Authors: Menzel Stephan , von Witzleben Moritz , Havel Viktor , Böttger Ulrich
Published: August 2018

In this work, the ultimate switching speed limit of redox-based resistive switching devices is discussed. Based on a theoretical analysis of the underlying physical processes, it is derived that the switching speed is limited by the phonon frequency.
A robust control system for targeting melanoma by a supermolecular DDMC/paclitaxel complex
Authors: Onishi Y. , Eshita Y. , Ji R.-C. , Kobayashi T. , Onishi M. , Mizuno M. , Yoshida J. , Kubota N.
Published: August 2018

A DEAE–dextran-MMA copolymer (DDMC)–paclitaxel (PTX) conjugate was prepared using PTX as the guest and DDMC as the host.
Stable and sensitive stimuli-responsive anisotropic hydrogels for sensing ionic strength and pressure
Authors: Hiratani Takayuki , Kose Osamu , Hamad Wadood Y. , MacLachlan Mark J.
Published: August 2018

Stimuli-responsive hydrogels that respond to pressure and ionic strength were prepared with large mono-domain, nematic organization of cellulose nanocrystals (CNCs).
Preparation of perovskite-embedded monodisperse copolymer particles and their application for high purity down-conversion LEDs
Authors: Lee Seung-Jea , Choi Jin Woo , Kumar Santosh , Lee Chang-Lyoul , Lee Jae-Suk
Published: August 2018

Fabrication of angle-independent 3D photonic crystals with organic–inorganic hybrid perovskite nanoparticle-embedded copolymer particles for the extraction of a narrow emissive spectrum without angle-dependency.
Iron depletion participates in the suppression of cell proliferation induced by lipin1 overexpression
Authors: Wang Jian , Wang Song , Sun Pengcheng , Cao Fangqi , Li Hui , Sun Jing , Peng Min , Liu Wenbin , Shi Ping
Published: August 2018

Lipin1 participates in the regulation of iron metabolism in human hepatic carcinoma cells.
In silico identification and characterization of sensory motifs in the transcriptional regulators of the ArsR-SmtB family
Authors: Roy Rima , Samanta Saikat , Patra Surajit , Mahato Nav Kumar , Saha Rudra P
Published: August 2018

The ArsR-SmtB family of proteins displays the greatest diversity among the bacterial metal-binding transcriptional regulators with regard to the variety of metal ions that they can sense. In the presence of increased levels of toxic heavy metals, these proteins dissociate from their cognate DNA upon the direct binding of metal ions to the appropriate sites, designated motifs on the proteins, either at the interface of the dimers or at the intra-subunit locations. In addition to the metal-mediated regulation, some proteins were also found to control transcription via redox reactions. In the present work, we have identified several new sequence motifs and expanded the knowledge base of metal binding sites in the ArsR-SmtB family of transcriptional repressors, and characterized them in terms of the ligands to the metal, distribution among different phyla of bacteria and archaea, amino acid propensities, protein length distributions and evolutionary interrelationships. We built structural models of the motifs to show the importance of specific residues in an individual motif. The wide abundance of these motifs in sequences of bacteria and archaea indicates the importance of these regulators in combating metal-toxicity within and outside of the hosts. We also show that by using residue composition, one can distinguish the ArsR-SmtB proteins from other metalloregulatory families. In addition, we show the importance of horizontal gene transfer in microorganisms, residing in similar habitats, on the evolution of the structural motifs in the family. Knowledge of the diverse metalloregulatory systems in microorganisms could enable us to manipulate specific genes that may result in a toxic metal-free environment.
Synthesis and properties of phosphorus and sulfur co-doped graphene
Authors: Lojka Michal , Jankovský Ondřej , Sedmidubský David , Mazánek Vlastimil , Bouša Daniel , Pumera Martin , Matějková Stanislava , Sofer Zdeněk
Published: August 2018

The derivatisation of graphene significantly extends its application potential beyond just a highly conductive material.
Gold nanorod-based fluorometric ELISA for the sensitive detection of a cancer biomarker
Authors: Alex Sruthi Ann , Chandrasekaran N. , Mukherjee Amitava
Published: August 2018

A gold nanorod-based fluorometric immunoassay (nanoELIFA) displayed ∼3.5-fold higher sensitivity (amplified signal) when compared to conventional ELIFA.
Synthesis, structures, antimicrobial activity and biosafety evaluation of pyridine-2-formaldehyde-N-susbtituted-thiosemicarbazonates of copper(ii)
Authors: Kaushal Mani , Lobana Tarlok S. , Nim Lovedeep , Kaur Jaskamal , Bala Ritu , Hundal Geeta , Arora Daljit S. , Garcia-Santos Isabel , Duff Courtney E. , Jasinski Jerry P.
Published: August 2018

Copper(ii) complexes with pyridine based thiosemicarbazones have shown high antimicrobial potential against different microbial strains, and were found to be biosafe with several complexes displaying high cell viability (90–98%).
Smart construction of palladium@polypyrrole nanocomposite coating on a magnetic support as a highly efficient and recyclable catalyst
Authors: Ni Xinjiong , Qiu Ji , Li Yunxing , Zhao Yaqian , Yang Cheng , Hong Liu
Published: August 2018

Herein is reported a facile and smart approach to fabricating polystyrene/Fe3O4/palladium@polypyrrole nanocomposite particles with high catalytic activity and stability for the degradation of methylene blue by NaBH4.
Fluorescent and photoacoustic bifunctional probe for the detection of ascorbic acid in biological fluids, living cells and in vivo
Authors: Xu Wenxiang , Chen Jingqin , Sun Shan , Tang Zhongdi , Jiang Kai , Song Liang , Wang Yuhui , Liu Chengbo , Lin Hengwei
Published: August 2018

A fluorescence and photoacoustic dual-modal probe based on a CoOOH nanoflake and red-emissive carbon dots hybrid was designed for ascorbic acid detection in biological fluids, living cells and in vivo.
Mercury ion–DNA specificity triggers a distinctive photoluminescence depression in organic semiconductor probes guided with a thymine-rich oligonucleotide sequence
Authors: Huang Jietao , Park Jin Hyuk , Back Seung Hyuk , Feng Yuhui , Cui Chunzhi , Jin Long Yi , Ahn Dong June
Published: August 2018

An organic semiconductor particle triggers a “distinctive depressed luminescence” when crystallized with thymine-rich DNA strands having motifs forming a quadruplex conformation upon specific interaction with mercury.
Fibrous strain sensor with ultra-sensitivity, wide sensing range, and large linearity for full-range detection of human motion
Authors: Wu Hanguang , Liu Qiang , Chen Hongwu , Shi Gaoquan , Li Chun
Published: August 2018

The FPC strain sensor exhibits superior comprehensive properties integrating extraordinary sensitivity, wide sensing range, low hysteresis, good linearity, and excellent stability. It can detect full-range human motions.
Metalloporphyrin-bound Janus nanocomposites with dual stimuli responsiveness for nanocatalysis in living radical polymerization
Authors: Li Xue , Li Jia Le , Huang Wen Gang , Zhang Xian-Zheng , Zhang Bin , Cai Tao
Published: August 2018

The capability to spatiotemporally regulate polymerization kinetics in response to dual external stimuli of light and magnetism offers exciting pathways to precisely manipulate polymer composition and sequence.
Rationally designing S/Ti3C2Tx as a cathode material with an interlayer for high-rate and long-cycle lithium–sulfur batteries
Authors: Jin Q. , Zhang N. , Zhu C. C. , Gao H. , Zhang X. T.
Published: August 2018

Lithium–sulfur batteries suffer from poor cycling stability and inferior rate capability, mainly caused by low conductivity and lithium polysulfide dissolution.
Exciton emissions in quasi one-dimensional layered KP15
Authors: Tian Nan , Liu Danmin , Yang Yanhan , Zhang Guoqing , Zhang Dandan , Zhang Yongzhe
Published: August 2018

Thickness dependent two neutral exciton properties in KP15 nanowires were reported and a large exciton binding energy (98 meV) was found.
Network pharmacology combined with functional metabolomics discover bile acid metabolism as a promising target for mirabilite against colorectal cancer
Authors: Sun Hui , Zhang Hong-lian , Zhang Ai-hua , Zhou Xiao-hang , Wang Xiang-qian , Han Ying , Yan Guang-li , Liu Liang , Wang Xi-jun
Published: August 2018

In this study, a combination of network pharmacology and metabolomics was used to explore the mechanism by which mirabilite regulates bile acid metabolism in the treatment of colorectal cancer.
Facile saccharide-free mimetics that recapitulate key features of glycosaminoglycan sulfation patterns
Authors: Lim Teck Chuan , Cai Shuting , Huber Roland G. , Bond Peter J. , Siew Chia Priscilla Xian , Khou Siv Ly , Gao Shujun , Lee Su Seong , Lee Song-Gil
Published: August 2018

We report a new class of saccharide-free glycosaminoglycan (GAG) mimetics where polyproline imparts facilely-made sulfation patterns with GAG-like structure, function and tunability.
Enzyme-free synthesis of cyclic single-stranded DNA constructs containing a single triazole, amide or phosphoramidate backbone linkage and their use as templates for rolling circle amplification and nanoflower formation
Authors: Chen Jinfeng , Baker Ysobel R. , Brown Asha , El-Sagheer Afaf H. , Brown Tom
Published: August 2018

Three different chemical cyclisation reactions yield biocompatible cyclic oligonucleotide templates for use in RCA and DNA nanoflower formation.
N-doping of graphene: toward long-term corrosion protection of Cu
Authors: Ren Siming , Cui Mingjun , Li Wensheng , Pu Jibin , Xue Qunji , Wang Liping
Published: August 2018

N-doped graphene could be a promising candidate for long-term corrosion protection of Cu because of its low conductivity compared to pristine graphene.
Methylammonium, formamidinium and ethylenediamine mixed triple-cation perovskite solar cells with high efficiency and remarkable stability
Authors: Chen Zhiliang , Zheng Xiaolu , Yao Fang , Ma Junjie , Tao Chen , Fang Guojia
Published: August 2018

A perovskite solar cell based on a novel triple-cation perovskite exhibits high PCE over 20% and remarkable stability.
On the mechanism behind freezing-induced chemical crosslinking in ice-templated cellulose nanofibril aerogels
Authors: Erlandsson Johan , Pettersson Torbjörn , Ingverud Tobias , Granberg Hjalmar , Larsson Per A. , Malkoch Michael , Wågberg Lars
Published: August 2018

The underlying mechanism related to freeze-induced crosslinking of aldehyde-containing cellulose nanofibrils (CNFs) has been investigated, and the critical parameters behind this process have been identified.
Highly simple and rapid synthesis of ultrathin gold nanowires with (111)-dominant facets and enhanced electrocatalytic properties
Authors: Jiang Xian , Qiu Xiaoyu , Fu Gengtao , Sun Jingze , Huang Zhenna , Sun Dongmei , Xu Lin , Zhou Jiancheng , Tang Yawen
Published: August 2018

Au nanowires with ultrathin diameters and high aspect ratios can be simply achieved within a few minutes, which exhibit extraordinary electrocatalytic performance toward the ORR in alkaline medium.
Silk fibroin and hydroxyapatite segmented coating enhances graft ligamentization and osseointegration processes of the polyethylene terephthalate artificial ligament in vitro and in vivo
Authors: Cai Jiangyu , Wan Fang , Dong Qinglin , Jiang Jia , Ai Chengchong , Sheng Dandan , Jin Wenhe , Liu Xingwang , Zhi Yunlong , Wang Siheng , Sun Yaying , Chen Jun , Shao Zhengzhong , Chen Shiyi
Published: August 2018

A silk fibroin and hydroxyapatite segmented coating ligament is fabricated to enhances graft ligamentization and osseointegration processes successfully.
Fluorescence assay for alkaline phosphatase activity based on energy transfer from terbium to europium in lanthanide coordination polymer nanoparticles
Authors: Wang Fengyi , Hu Xuan , Hu Jing , Peng Qianqian , Zheng Baozhan , Du Juan , Xiao Dan
Published: August 2018

An effective fluorescence assay alkaline phosphatase (ALP) method was developed by using bimetallic lanthanide coordination polymer nanoparticles (Tb-GMP-Eu CPNs).
Experience‐based SEEG planning: from retrospective data to automated electrode trajectories suggestions
Authors: Scorza Davide , Amoroso Gaetano , Cortés Camilo , Artetxe Arkaitz , Bertelsen Álvaro , Rizzi Michele , Castana Laura , De Momi Elena , Cardinale Francesco , Kabongo Luis
Published: August 2018

StereoElectroEncephaloGraphy (SEEG) is a minimally invasive technique that consists of the insertion of multiple intracranial electrodes to precisely identify the epileptogenic focus. The planning of electrode trajectories is a cumbersome and time‐consuming task. Current approaches to support the planning focus on electrode trajectory optimisation based on geometrical constraints but are not helpful to produce an initial electrode set to begin with the planning procedure. In this work, the authors propose a methodology that analyses retrospective planning data and builds a set of average trajectories, representing the practice of a clinical centre, which can be mapped to a new patient to initialise planning procedure. They collected and analysed the data from 75 anonymised patients, obtaining 30 exploratory patterns and 61 mean trajectories in an average brain space. A preliminary validation on a test set showed that they were able to correctly map 90% of those trajectories and, after optimisation, they have comparable or better values than manual trajectories in terms of distance from vessels and insertion angle. Finally, by detecting and analysing similar plans, they were able to identify eight planning strategies, which represent the main tailored sets of trajectories that neurosurgeons used to deal with the different patient cases.
Concepts for augmented reality visualisation to support needle guidance inside the MRI
Authors: Mewes André , Heinrich Florian , Hensen Bennet , Wacker Frank , Lawonn Kai , Hansen Christian
Published: August 2018

During MRI‐guided interventions, navigation support is often separated from the operating field on displays, which impedes the interpretation of positions and orientations of instruments inside the patient's body as well as hand–eye coordination. To overcome these issues projector‐based augmented reality can be used to support needle guidance inside the MRI bore directly in the operating field. The authors present two visualisation concepts for needle navigation aids which were compared in an accuracy and usability study with eight participants, four of whom were experienced radiologists. The results show that both concepts are equally accurate ( and ), useful and easy to use, with clear visual feedback about the state and success of the needle puncture. For easier clinical applicability, a dynamic projection on moving surfaces and organ movement tracking are needed. For now, tests with patients with respiratory arrest are feasible.
WiFi‐based passive sensing system for human presence and activity event classification
Authors: Li Wenda , Tan Bo , Piechocki Robert J.
Published: August 2018

Detection of human presence and activity event classification are of importance to a variety of context‐awareness applications such as e‐Healthcare, security, and low impact building. However, existing radio frequency identification tags, wearables, and passive infrared approaches require the user to carry dedicated electronic devices that suffer from problems of low detection accuracy and false alarms. This study proposes a novel system for non‐invasive human sensing by analysing the Doppler information contained in the human reflections of WiFi signal. Doppler information is insensitive to stationary objects, thus there is no need for any scenario‐specific calibration which makes it ideal for human sensing. We also introduce the time‐frequency domain feature vectors of WiFi Doppler information for the support vector machine classifier towards activity event recognition. The proposed methodology is evaluated on a software defined radio system together with the experiment of five different events. The results indicate that the proposed system is sufficient for indoor context awareness, with 95.3% overall accuracy for event classification and 93.3% accuracy for human presence detection, which outperforms the traditional received signal strength approach where accuracy is 69.3% for event classification and 83.3% for human presence detection.
Architecture design of the air pollution mapping system by mobile crowd sensing
Authors: Vahdat‐Nejad Hamed , Asef Mahsa
Published: August 2018

Today, mobile phones have become smarter than ever before and people are always carrying them. Mobile phones are not only references for computing and communications, but also a great option for gathering information about individuals and their surroundings. This study investigates the problem of mapping air pollution by leveraging a crowd of people that are equipped with smartphones. The proposed system uses mobile cloud computing as well, in order to collect and aggregate air pollution data. At the layer of mobile devices, air pollution is measured by local portable sensors through the exposure of users to the surrounding environment. Afterwards, these pieces of local information generated by the crowd of users are aggregated in the cloud layer. The proposed system is implemented in two components for mobile device and cloud. Furthermore, the scenario‐based approach is used to evaluate the functionality of the system.
Bivariate luminosity-HI mass distribution function of galaxies based on the NIBLES survey
Authors: Butcher Z. , Schneider S. , van Driel W. , Lehnert M. D.
Published: August 2018

We present a new optical luminosity-HImass bivariate luminosity function (BLF) based on HIline observations from the Nançay Interstellar Baryons Legacy Extragalactic Survey (NIBLES). NIBLES sources lie within the local universe (900 ≤ cz ≤ 12 000 km s−1) and were chosen from SDSS DR5 such that the optical luminosity function was sampled as uniformly as possible. The HImass function (HIMF) derived from our raw-data BLF, which is based on HIdetections only, is consistent with the HIMFs derived from other optically selected surveys in that the low-mass slope is flatter than those derived from blind HIsurveys. However, spanning the entire luminosity range of NIBLES, we identify a highly consistent distribution of the HIgas mass to luminosity ratio (gas-to-light ratio) with a predictable progression in the meanMHI/Lrratio as a function ofLr. This consistency allows us to construct plausible gas-to-light ratio distributions for very low-luminosity bins which lie outside the NIBLES sample. We also identify a ∼10% decrease in detection fraction for galaxies fainter than log(Lr) = 9.25, consistent with the expected decrease due to distance and sensitivity effects. Accounting for these trends, we reconstruct plausible gas-to-light distributions spanning luminosity bins down to log(Lr) = 5.25, thus producing a corrected BLF. This corrected BLF is in good qualitative agreement with optical luminosity-HImass distributions from the ALFALFA survey and is able to accurately reproduce blind survey HIMFs, lending credibility that this two dimensional optical luminosity-HImass distribution is an accurate representation of the volume density distribution of galaxies in the local universe. We also note that our agreement with HIMFs from other surveys is dependent on accounting for all systematic differences such as selection method, Hubble constant and HIflux scale.
Characterization of Laciana Valley District mine water as geothermal resource
Authors: Matas Alejandro , García-Carro Francisco , Loredo Jorge
Published: August 2018

Laciana Valley District is a coal mining region located in northern Spain. This region counts with several mining facilities, among them: eight underground mines (six mountain mines and two mine shafts) and three open pit mines. Nowadays, all the mining facilities have been closed down and are flooded. The water found inside them could be used as a geothermal resource due to its thermal properties and the proximity to population. The aim of the study is to analyze the water of the facilities located in Laciana Valley and determine its potential to be used as a geothermal resource for a district heating system. In order to achieve this goal an extensive field work has been performed, nine different mine water discharges have been chosen and several water characteristics have been selected for analysis. The parameters measured have been pH, conductivity, hardness, temperature, turbidity and alkalinity. The results have been evaluated in order to determine the fluctuations of the physico-chemical parameters throughout a hydrological year and the mining facilities have been compared between each other regarding their mine water quality. The analysis of all the information gathered in the study shows a noteworthy thermal potential in the water of the abandoned mines of the region.
Prediction of Horizontal Axis Wind Turbine Rotor Performance: Bond Graph Approach
Authors: Jouilel Naima , Radouani Mohammed , El Fahime Benaissa
Published: August 2018

Modeling wind energy conversion systems is a difficult task that requires the use of a unified language gathering all aspect of energies involved such as kinetic energy, mechanical energy, and electrical energy. Bond Graph methodology is an appropriate tool to analyze wind turbine dynamic behavior since the whole system is modelled in the same frame. Herein, a methodology for HAWT's rotor modeling is proposed based on Bond Graph, aerodynamic laws and Rayleigh Beam theory. It takes into consideration the profile, chord, and twist change along the blade. The model is validated using 20-Sim software and then compared to other models from literature. Simulation results show a better value of power coefficient in comparison with works using the same tools.
An overview of the wind power potential in the Romanian coastal environment - moving from onshore to offshore
Authors: Niculescu Dragos M. , Rusu Eugen V. C.
Published: August 2018

In the past few years in Romania the total installed capacity reached 3025MW. Because the Europe Union is pursuing to obtain an increase in renewable energy by 2020 to cover 20% of the energy consumption with renewable energy maybe in the near future in Romania the wind energy parks will start to be build off shore where the wind energy is more powerful. From this perspective, the present work is trying to provide a better picture to the wind energy resources at the Romanian shore. The measured data was provided by NOAA [1] from different points (weather stations) four along the Romanian shore and one off-shore. The measured data was compared with data from the Global Wind Atlas model [2]. According to the analysis, there are discrepancies between the measured results and those provided by the model, but the two sets of data show that in the northern part of the off-shore the power density and the wind speed is higher than in the south.
Analysis-based results on the delineation of prearrangement areas for marine renewable energy installations in the Western Black Sea Basin
Authors: Mateescu Razvan , Vlasceanu Elena , Rusu Liliana
Published: August 2018

The selection of optimum places for installations and suitable solutions for the use of marine renewable energy requires a complex approach as well as a longer period of time and a spatial scale hydrodynamic characterization, which time-limited and local studies are incapable to provide. To that end, the complex monitoring and modelling approach on the evolution of large-scale marine and coastal processes in response to both direct and indirect human intervention and to natural phenomena variability is an increasingly important issue in the Integrated Coastal Zone Management (ICZM) and MSP implementation, all over the world. The installation of wave/currents devices within coastal and marine areas involves the knowledge of the physical, economic and social impact of the continuous modification of the marine hydrodynamics, due to the new changes induced in the marine climate. The present work adequately takes into account the combined results of Marine Spatial Planning Directive applications within Western Black Sea Basin (WBSB). The MSP approach allows the selection of efficient areas for the installation of marine waves and currents devices converters (WECs), in relation with the potential environmental impact of adjacent MPAs, taking into account the induced strong variability of renewable devices/convertors on the coastal processes. Recommended areas for the installation of the above-mentioned devices within highly energetic areas asked for a proper response in order to develop a detailed delineation targeting a sustainable coastal protection.
Solar Energy as Expedient Alternatives for Nuclear Energy
Authors: Younas T , Rasheed H , Rehman M M , Ramzan R
Published: August 2018

The development of solar power technologies is considered to be the key solutions for fulfilling ever increasing worldwide demand for energy. This paper reflects the nature, characteristics, similarities, and differences between nuclear and solar energies. It also discusses their technologies, their impact on different aspects of life and public attitudes about them. Generally, nuclear energy is considered to be destroyed due to uncontrollable chemical reactions associated with harvesting of nuclear energy. Energy requirement of the world is increasing day by day, and using conventional methods to fulfil this requirement might cause devastating effects on atmosphere due to an emission of different harmful by-products released. In this paper, alternate methods of producing energy are discussed and a detailed analysis of its environmental effects, sustainability and cost have been discussed.
An air circulation purifying system based on PLC
Authors: Chen Yin , Han Chengliang , Chen Peng , Chen Zong , Liu L Y , Du T
Published: August 2018

Existing air purifiers are mostly indoor air circulation, and most of them cannot achieve indoor and outdoor air circulation and provide fresh air to room. At the same time, the current air purifier filter on the market after absorbing a large amount of dust and other pollutants, if not replaced in time, is likely to cause secondary pollution. In response to these problems, this paper carried out an exploratory research that can achieve indoor and outdoor air purification device. According to the clean air volume of HEPA filter, the pressure of fan and the cross-sectional area of filter are determined, meanwhile, the air resistance of indoor and outdoor circulating air purifier, the effect of air blower on air purification efficiency and filter CADR are discussed in detail. According to the filtering characteristics of single-layer filter, a kind of indoor and outdoor circulating air purifier-single-layer filter type air purifier was designed. Among the air purifier, the PLC control circuit is used to achieve single-layer filter air purifier filter automatically replace.
Estimation of the resonance amplitude in machines with inertia vibrator in the coast-down phase
Authors: Cieplok Grzegorz
Published: August 2018

The work concerns mechanical systems with transient resonance formed as a result of an unbalanced rotating mass passing through an area of the system's natural frequency. In particular, this concerns over-resonant vibrating machines driven by inertia vibrators, which during start-up and coast-down pass through the natural frequency area related to the vibrating mass – flexible suspension system. The work analyses a system consisting of a soft-mounted machine body excited into vibrations by means of the inertia vibrator in order to designate the amplitude of resonant vibration, taking into consideration strong coupling between movements of the body and vibrator. The research results are presented in the form of nomograms and approximation formulas expressed in terms of relative parameters. The results of the theoretical research were verified on the laboratory model and industrial machines.
An operational solar wind prediction system transitioning fundamental science to operations
Authors: Wang Jingjing , Ao Xianzhi , Wang Yuming , Wang Chuanbing , Cai Yanxia , Luo Bingxian , Liu Siqing , Shen Chenglong , Zhuang Bin , Xue Xianghui , Gong Jiancun
Published: August 2018

We present in this paper an operational solar wind prediction system. The system is an outcome of the collaborative efforts between scientists in research communities and forecasters at Space Environment Prediction Center (SEPC) in China. This system is mainly composed of three modules: (1) a photospheric magnetic field extrapolation module, along with the Wang-Sheeley-Arge (WSA) empirical method, to obtain the background solar wind speed and the magnetic field strength on the source surface; (2) a modified Hakamada-Akasofu-Fry (HAF) kinematic module for simulating the propagation of solar wind structures in the interplanetary space; and (3) a coronal mass ejection (CME) detection module, which derives CME parameters using the ice-cream cone model based on coronagraph images. By bridging the gap between fundamental science and operational requirements, our system is finally capable of predicting solar wind conditions near Earth, especially the arrival times of the co-rotating interaction regions (CIRs) and CMEs. Our test against historical solar wind data from 2007 to 2016 shows that the hit rate (HR) of the high-speed enhancements (HSEs) is 0.60 and the false alarm rate (FAR) is 0.30. The mean error (ME) and the mean absolute error (MAE) of the maximum speed for the same period are −73.9 km s−1 and 101.2 km s−1, respectively. Meanwhile, the ME and MAE of the arrival time of the maximum speed are 0.15 days and 1.27 days, respectively. There are 25 CMEs simulated and the MAE of the arrival time is 18.0 h.
Moderne Antidiabetika in der Kardiologie
Authors: Schneider Christian , Pfister Roman
Published: August 2018

Diabetes mellitus Typ 2 verkürzt die Lebenserwartung von Betroffenen in Abhängigkeit des Ausmaßes kardiovaskulärer Begleiterkrankungen um bis zu 22 Jahre. Ziel einer Therapie muss daher die Verbesserung der Prognose sein. Neue Medikamente könnten dafür vorteilhaft sein. Zu den neuen blutzuckersenkenden Medikamenten zählen GLP-1-Rezeptoragonisten, DPP-4-Inhibitoren und SGLT-2-Inhibitoren. GLP1-Rezeptoragonisten führen zu einer starken Blutzuckersenkung, sind jedoch häufig mit gastrointestinalen Symptomen assoziiert. DPP-4-Inhibitoren und SGLT-2-Inhibitoren führen zu einer moderaten Blutzuckersenkung und sind in der Regel gut verträglich. Unter den modernen blutzuckersenkenden Medikamenten sind Empagliflozin und Liraglutid die einzigen Medikamente, die das kardiovaskuläre Risiko und die Gesamtsterblichkeit bei Patienten mit kardiovaskulären Vorerkrankungen signifikant reduzieren. Für andere Substanzen ist dies bislang in prospektiv randomisierten Studien nicht belegt. Diese sollten daher in der Behandlung von Hochrisiko-Patienten bevorzugt werden.
Assoziation zwischen Geburtsverletzungen und der Einführung geburtshilflicher Observationsmaßnahmen: eine retrospektive Kohortenstudie
Authors: Birri Jana , Kreft Martina , Zimmermann Roland , Kimmich Nina
Published: August 2018

Einführung Ein Großteil aller Geburten geht mit irgendeiner Form von Geburtsverletzung einher. Dies kann enorme physische wie auch psychische Auswirkungen auf die betroffenen Frauen haben. Die Bemühungen von Geburtshelfern und Hebammen zielen daher darauf ab, Geburtsverletzungen weitestgehend zu reduzieren. Hierzu haben wir die Assoziation zwischen der Einführung verschiedener geburtshilflicher Observationsmaßnahmen in der Gebärabteilung und der Inzidenz und Lokalisation der verschiedenen Arten von Geburtsverletzungen untersucht.

Material und Methode In einer retrospektiven Datenanalyse evaluierten wir nullipare und multipare Frauen mit Einlingsschwangerschaften in Schädellage, die in unserem Universitätsspital zwischen Oktober 2014 und September 2015 vaginal ein Kind zur Welt brachten. Wir untersuchten 3 unterschiedliche Zeitintervalle zu je 4 Monaten (T1=4 Monate vor Einführung der Observationsmaßnahmen, T2=0–4 Monate danach und T3=5–8 Monate danach). Zielparameter waren die Inzidenz und Verteilung der verschiedenen Typen der Geburtsverletzungen während der 3 unterschiedlichen Zeiträume.

Resultate Die Inzidenz aller Arten von Geburtsverletzungen sank nicht signifikant von 95,52% bei Nulliparen und 68,53% bei Multiparen während T1 auf 89,92% und 62,27% während T3, v. a. in Form eines Rückgangs an perinealen und vulvären/labialen Verletzungen hin zu einem Anstieg an vaginalen Verletzungen. Die Rate an Episiotomien und höhergradigen Dammrissen blieb zwischen den Zeitintervallen hierbei jedoch stabil (Nullipare 33 und 3%, Multipare 10 und 0,4%)

Schlussfolgerung Die Inzidenz von Geburtsverletzungen ist gesamthaft hoch, wobei Verletzungen hauptsächlich in Form von Dammrissen ersten und zweiten Grades sowie als Vaginal- und Labienrisse auftreten. Die Einführung verschiedener geburtshilflicher Observationsmaßnahmen in der Gebärabteilung ist mit einer Veränderung in der Inzidenz von Geburtsverletzungen und mit einer Verlagerung derselben von extern nach intern vergesellschaftet, wahrscheinlich bedingt durch ein bedachteres Handeln des geburtshilflichen Personals. Die Einführung solcher Observationsmaßnahmen könnte daher eine Verbesserung geburtshilflichen Handelns bringen, wovon Frauen unter der Geburt profitieren könnten. Nichts desto trotz darf der alleinige Effekt, den eine Beobachtung und Überwachung während des Verlaufs von Observationsstudien bringt, nicht außer Acht gelassen werden.
A Domino Process for the Sustainable Synthesis of Quinazolin-4(3H)-ones with Direct Chemo- and Regioselective Bromination
Authors: Sheikhi Ehsan , Adib Mehdi , Yazzaf Rozita , Jahani Mehdi , Ghavidel Mehdi
Published: August 2018

An efficient approach is reported for the direct and sustainable construction of quinazolin-4(3H)-ones through a three-component reaction of isatoic anhydride, primary amines, and bromoacetyl bromide or chloroacetyl chloride in the presence of K2CO3 in DMSO. With bromoacetyl bromide, mono- or dibrominated quinazolinone scaffolds were obtainable in a chemo- and regioselective manner.