bluuebunny/crossref_metadata_2025 huggingface dataset:
Minat Nasabah dalam Menggunakan Mobile Banking Jenius BTPN Manado
Authors: Patangari Anatasha Nursaphira , Mahmud Abdul Syafiq , Makka Misbahul Munir
Published: July 2022

Penelitian ini bertujuan untuk mengetahui faktor-faktor apa saja yang mempengaruhi minat nasabah dalam menggunakan mobile banking Jenius, mobile banking jenius adalah salah satu fasilitas dari Bank BTPN dimana yang biasanya bank ini menyediakan layanan hanya untuk para pension namun sekarang bank btpn sudah mengeluarkan fasilitas yang bisa dipakai oleh non pension, apliaksi mobile banking memungkinkan nasabah sebuah bank dapat melakukan hampir semua jenis transaksi melalui sarana internet. Penelitian di lakukan di kota Manado dengan menggunakan metode penelitian kualitatif, metode pengumpulan data dilakukan dengan tiga cara yaitu observasi. Wawancara, dan dokumentasi, pengumpulan data dilakukan untuk memperoleh data di lapangan, kemudian di analisis secara deskriptif kualitatif. Hasil temuan penelitian menunjukkan bahwa ketertarikan nasabah terhadap mobile banking karena kemudahan, kenyamanan, dan keamanan yang diberikan oleh aplikasi mobile banking jenius, dengan kemudahan yang diberikan nasabah bisa melakukan transaksi dimana saja dan kapan saja tanpa harus ke bank
Penanaman karakter sikap bersahabat melalui storytelling
Authors: Yunistianingsih Yunistianingsih , Husain Itsnain Alfajri
Published: July 2022

friendly attitude is needed by elementary school children to be able to liven up a fun atmosphere in learning. Even so, there was often an atmosphere that does not show the character of a friendly attitude. Storytelling is considered to be able to increase friendly attitudes. This study aims to determine whether the character of a friendly attitude can be improved through storytelling. This was a qualitative descriptive study. The primary data in this study came from two teachers and three students. Data were collected through interviews, observations, and documentation studies. Data were analyzed through data reduction, data display, verification, and conclusions. The results showed that the character of a friendly attitude can be improved through storytelling. Storytelling is able to break down potential conflicts. One of the obstacles in implementing this technique is that it requires the selection of an interesting theme. As a solution to the obstacles faced, preparation was needed in carrying out storytelling.
Layanan informasi untuk meningkatkan penyesuaian diri siswa
Authors: Risnawati Risnawati , Salahuddin Salahuddin
Published: July 2022

self-adjustment is an ability that students need to have in the transition period. Sometimes there are still students who have not been able to adjust themselves optimally. One of the efforts that can be provided is through information services. The purpose of this study was to determine whether information services were able to improve students' self-adjustment. This research is an experimental type of quantitative research with a one group pretest-posttest control group design. The population in this study was class VIIC MTsNegeri 2 Palu totaling 34 students. All students were used as research samples. To measure the level of adjustment of students used adjustment scale. Data were analyzed through descriptive and inferential statistics. The results showed that information services were able to improve students' self-adjustment
Teachers’ Strategies for Supporting Transgender and/or Gender-Expansive Elementary School Students
Authors: Mangin Melinda M.
Published: July 2022

This qualitative study examines elementary teachers’ strategies for supporting trans and/or gender-expansive elementary students. The findings come from observations and interviews with a purposive sample of 31 teachers from five elementary schools with principals whom parents characterized as supporting their transgender and/or gender-expansive children. Findings indicate that elementary teachers used three broad strategies to support transgender and/or gender-expansive students. Teachers decreased gendered practices, increased discussions about gender, and affirmed children’s gender identity and expression. The consistency of teachers’ efforts to support trans and/or gender-expansive students was challenged by entrenched habits and their beliefs about the relevance of supportive practices. The study results contribute to the nascent knowledge base on educational practices that may improve the conditions for transgender and/or gender-expansive elementary school students.
Differences in Trans Employees’ and Students’ School Experiences
Authors: Suárez Mario I. , McQuillan Mollie T. , Keenan Harper B. , Iskander Lee
Published: July 2022

Little is known about the professional experiences of trans school workers. This brief describes the demographic characteristics of a non-random sample of 296 trans PK–12 school workers (i.e., teachers, administrators, staff) in the United States and Canada and reports their workplace experiences and the structural and social supports for trans employees compared to trans students. The analysis suggests that although most respondents are satisfied with their role, they experience high levels of discrimination and harassment, and there is a lack of administrative guidance for trans staff compared to trans students. The brief concludes with a discussion of the implications for school leadership and policy.
Impact of Violence against Women on Sexual and Reproductive Health: Research Protocol and Results from a Pilot Study
Authors: Mendoza-Huertas Loreto , Mendoza Nicolas
Published: July 2022

Objectives: Violence against women (VAW) is associated with a deterioration of endocrine function with consequences similar to those of premature ovarian failure in women. The main objective of this study is to evaluate the hormonal repercussions of VAW and, secondly, to analyse the cardio-metabolic, bone, cognitive, psychological, and psychosexual consequences of hypoestrogenism secondary to VAW. Materials and Methods: A cross-sectional study will be conducted on women of any age who have suffered VAW at some point in their lifespan, whether psychological, sexual, or physical. Clinical, hormonal, cardio-metabolic, bone, psychological, and psychosexual parameters will be analysed. Results: The pilot study from the first 23 women show that all of them are suffering from severe sexual dysfunction. In addition, all women reported menstrual irregularity and hypoestrogenism (including two cases of premature ovarian failure) since the VAW episode. Conclusions: VAW is a pandemic that affects all women equally, regardless of their age, status, social background, or education. Despite the claims made by certain groups, VAW does not depend on women, but rather it affects women and is clearly harmful to their sexual, reproductive, and general health.
Real World Application of Chemotherapy Response Score in High Grade Serous Cancer of the Ovary
Authors: Ferrari Federico , Cisotto Francesca , Gambino Angela , Ferrari Filippo Alberto , Ardighieri Laura , Forte Sara , Sartori Enrico , Odicino Franco
Published: July 2022

Background: High grade serous cancers (HGSC) of gynecological origin can be treated with neoadjuvant chemotherapy (NACT) and subsequent interval debulking surgery (IDS) when upfront surgery is not feasible. Chemotherapy response score (CRS) was proposed to evaluate on pathological specimens at IDS the response to NACT. Objective: We aim to assess survival outcomes stratified by CRS in HGSC patients and to explore interaction with residual disease (RD) after surgery. Methods: We identified all consecutive patients with HGSC at advanced stage (FIGO III–IV) that underwent NACT and IDS. We collected baseline data as well as survival data such as disease-free survival (DFS) and overall survival (OS). CRS was assessed on adnexal and omental specimens based on a three-tier classification. We conducted multivariate cox regression analyses of CRS classifications (CRS 1 vs 2 vs 3, CRS 1+2 vs 3 and CRS 1 vs 2+3) using RD as covariate. Results: We enrolled 47 patients with a median follow-up of 25 months (IQR: 11–78). RD after IDS failed to correlate with DFS (p = 0.73) and OS (p = 0.93). Adnexal CRS 2 (HR 0.4; 95% CI 0.2–1.0; p = 0.05) and CRS 3 (HR 0.30; 95% CI 0.11–0.65; p = 0.04) correlated with longer DFS. Moreover, CRS 2 (HR 0.12; 95% CI 0.04–0.33; p < 0.01) and CRS 3 (HR 0.06; 95% CI 0.02–0.20; p < 0.01) on adnexal specimens were significantly associated with improved OS. Neither the omental three-tier nor the two-tier classifications correlated with DFS and OS. Conclusions: CRS classification is apparently a simple and reproducible method. In our study the adnexal three-tier system correlate with DFS and OS independently from RD at IDS. Further studies are needed to clarify the clinical role of CRS classification.
Does a Diet Rich in the Bacterium Rhodopirellula rubra Improve Daphnia magna Performance?
Authors: Marinho Maria , Jesus Gustavo , Spencer Luís , Catita José , Lage Olga M. , Antunes Sara C.
Published: July 2022

Background: In the wild various organisms contribute to daphnids diet. This study, intendeds to evaluate the potential of the concentration of Rhodopirellula rubra as a single or supplementary food source for Daphnia magna. Methods: Feeding assays were performed according to standard guidelines for chronic assays (21 days), and life-history parameters and several biomarkers (protein content, oxidative stress, energetic reserves and pigments) were measured. Five food regimens were conducted with 20 individual replicates (A - R. subcapitata; 0.2 - suspension of R. rubra at 0.2 arbitrary units (AU); 0.4 - suspension of R. rubra at 0.4 AU; 0.2+A - suspension of R. rubra at 0.2+alga; 0.2+A-suspension of R. rubra at 0.4 AU + alga). Additionally, the effects of three diets (A, 0.2, and 0.2+A) on the longevity of D. magna were assessed. Results: The five diets showed a different C, N, and carotenoids composition, with an increase in the mixed diets. The results confirmed that the mixed diets improved D. magna life-history parameters. A decrease in glycogen, and the increase of haemoglobin, protein, and gluthione-S-transferase (GST) were observed. Furthermore, D. magna fed with bacterial single diets, presented worsen life history parameters and a decrease in the protein content. An induction of oxidative stress response (increased catalase and GST), and a significant decrease in lipid peroxidation and an accumulation of glycogen and carotenoids were observed. Overall, an increase in the amount of R. rubra provided to D. magna, from 0.2 AU to 0.4 AU, negatively impacted daphnid performance. No significant effects on Daphnia longevity (a 110-day assay) were observed among the three diets tested. However, a significant survival percentage and fertility (cumulative offspring is more than twice) was observed when D. magna was fed with the mixed diet. Conclusions: Results demonstrated that different diets provided a nutritional diversified food to the daphnids that induced differences in D. magna performance. The mixed diets proved to be beneficial (with increase in offspring) on D. magna performance, independently of the bacterial concentration tested. When in single diet, bacterial concentration is not nutritionally sufficient to raise D. magna even when in increased concentration.
Targeting the Macrophage-Ferroptosis Crosstalk: A Novel Insight into Tumor Immunotherapy
Authors: Zhou Zirui , Xu Bo , Hu Ning , Guo Zijian , Bao Wanlin , Shao Bin , Yang Wenbin
Published: July 2022

Ferroptosis is an emerging form of non-apoptotic, regulated cell death that is mechanistically dependent on aberrant iron accumulation and excessive lipid peroxidation. Further evidence indicates that ferroptosis plays a crucial role in the efficacy of tumor immunotherapy. Ferroptosis is often constrained by tumor-associated macrophages (TAMs), and this poses a challenge to clinicians aiming to exploit the potency of immunotherapy to treat various forms of cancer. Current advances revealed a dual character to TAMs in regulating tumor ferroptosis. Specifically, some signaling molecules released from cells undergoing ferroptosis can exert effects on TAM polarization. In this review, we summarize the currently characterized mechanisms of macrophage-ferroptosis crosstalk, discuss how macrophage-ferroptosis crosstalk affects the outcome of tumor immunotherapy, and provide an overview of current advances that seek to leverage this crosstalk to improve cancer immunotherapy efficacy. Despite the fact that further efforts are still required to achieve a more comprehensive understanding of the mechanisms that control this signaling, targeting macrophage-ferroptosis crosstalk has clear potential for reversing immunotherapeutic resistance and may shed light on new therapeutic strategies to overcome some advanced and metastatic malignancies.
Identification of DNA Methylation Signature and Rules for SARS-CoV-2 Associated with Age
Authors: Chen Lei , Liao Huiping , Huang Guohua , Ding Shijian , Guo Wei , Huang Tao , Cai Yudong
Published: July 2022

Background: COVID-19 displays an increased mortality rate and higher risk of severe symptoms with increasing age, which is thought to be a result of the compromised immunity of elderly patients. However, the underlying mechanisms of aging-associated immunodeficiency against Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains unclear. Epigenetic modifications show considerable changes with age, causing altered gene regulations and cell functions during the aging process. The DNA methylation patterns among patients with coronavirus 2019 disease (COVID-19) who had different ages were compared to explore the effect of aging-associated methylation modifications in SARS-CoV-2 infection. Methods: Patients with COVID-19 were divided into three groups according to age. Boruta was used on the DNA methylation profiles of the patients to remove irrelevant features and retain essential signature sites to identify substantial aging-associated DNA methylation changes in COVID-19. Next, these features were ranked using the minimum redundancy maximum relevance (mRMR) method, and the feature list generated by mRMR was processed into the incremental feature selection method with decision tree (DT), random forest, k-nearest neighbor, and support vector machine to obtain the key methylation sites, optimal classifier, and decision rules. Results: Several key methylation sites that showed distinct patterns among the patients with COVID-19 who had different ages were identified, and these methylation modifications may play crucial roles in regulating immune cell functions. An optimal classifier was built based on selected methylation signatures, which can be useful to predict the aging-associated disease risk of COVID-19. Conclusions: Existing works and our predictions suggest that the methylation modifications of genes, such as NHLH2, ZEB2, NWD1, ELOVL2, FGGY, and FHL2, are closely associated with age in patients with COVID-19, and the 39 decision rules extracted with the optimal DT classifier provides quantitative context to the methylation modifications in elderly patients with COVID-19. Our findings contribute to the understanding of the epigenetic regulations of aging-associated COVID-19 symptoms and provide the potential methylation targets for intervention strategies in elderly patients.
Potential Impact of N6-Methyladenosine RNA Methylation on Vision Function and the Pathological Processes of Ocular Diseases: New Discoveries and Future Perspectives
Authors: Li Xiaohua , Ma Binyun , Liao Mengyu , Li Lingke , Zhang Xiaodan , Du Mei , Yu Jinguo , He Shikun , Yan Hua
Published: July 2022

N6-methyladenosine (m6A) methylation/modification plays a critical role in various biological processes through post-transcriptional ribonucleic acid (RNA) modification, which involves RNA processing, nuclear export, translation and decay. Functionally, m6A modification may be involved in ocular cell growth and differentiation, stem cell identity, development, haemostasis and innate versus adaptive immunity. Aberrations in m6A methylation may mediate numerous pathological conditions in the eye, including microorganism infection, inflammation, autoimmune disease, senescence, degeneration, epithelial–mesenchymal transition, fibrosis, angiogenesis, tumorigenesis and complex eye diseases. In this review, we have discussed the relevance of m6A modification to precision medicine, stem cell directional differentiation, biomarkers of eye diseases and m6A methylation activators and inhibitors. In addition, we summarised the challenges and future research directions in the field related to visual function and eye diseases.
Combined Analysis of Disseminated Tumor Cells (DTCs) and Circulating Tumor DNA (ctDNA) in a Patient Suffering from Triple Negative Breast Cancer Revealed Elevated Risk
Authors: Nel Ivonne , Herzog Henrike , Aktas Bahriye
Published: July 2022

Background: Disseminated tumor cells (DTCs) in bone marrow aspirates of patients with primary breast cancer may serve as independent prognostic markers associated with impaired survival. Due to limited therapy options and high risk of recurrence particularly, women diagnosed with the aggressive triple negative breast cancer (TNBC) require personalized treatment choices. Genetic profiling of circulating cell-free tumor DNA (ctDNA) might help to find individual treatment options and to monitor disease course. Methods: Here we report the case of a 66-year-old patient with TNBC. She received neoadjuvant chemotherapy (NACT) that had to be interrupted due to intolerance. Surgical resection of the residual tumor resulted in pathologic complete response (pCR), though. Results: Bone marrow aspiration during surgery revealed an unusual high number of DTCs and thus elevated risk for recurrence. Analysis of pre-surgical blood and urine samples revealed the presence of plasma-derived and urinary ctDNA after NACT and indicated poor prognosis. Subsequent targeted sequencing showed that pathogenic variants occurred in urinary and plasma-derived ctDNA emphasizing the potential of liquid biopsy usage for early detection of relapse. Despite the detection of residual molecular disease after NACT, the presented patient reached pCR and could benefit from standard treatment until present. Conclusions: In this case, liquid biopsy based biomarkers did not necessarily correlate to clinical outcome. Further, ctDNA analysis did not reveal approved therapeutic options to target the identified pathogenic variants. Adjuvant bisphosphonate treatment was applied based on the positive DTC status and may improve the patients’ prognosis. Further investigations are required to identify TNBC patients at risk for recurrence.
Tumor-Suppressor Gene Transmembrane Protein 98 Promotes Proliferation and Inhibits Apoptosis in Ovarian Cancer
Authors: Wu San-Gang , Xu Jing-Ying , Lei Jian , Hu Min , Zhou Juan
Published: July 2022

Background: Ovarian cancer (OC) is the most deadly tumor in gynecology and there is no effective biomarker for diagnosis and treatment. The role of Transmembrane Protein 98 (TMEM98) in ovarian cancer is still unclear. Methods: The expression and prognostic effect of TMEM98 in OC were analyzed using the public database. Cell Counting Kit-8 proliferation experiment, scratch experiment, Transwell invasion experiment, flow cytometry, TUNEL staining, and in vivo and vitro experiment were used. Results: TMEM98 was significantly downregulated in OC tissues and cell lines compared to the normal ovarian tissue and cells lines. In addition, patients with lower TMEM98 levels exhibited inferior survival. Low expression of the TMEM98 promoted proliferation, migration, invasion, vasculogenic mimicry, and inhibited apoptosis in OC cells. The expression of Caspase-3 was significantly downregulated and the expression of Bcl-2 was significantly increased in the silencing-TMEM98 group. Moreover, low expression of TMEM98 promotes OC development in vivo. Bioinformatics analysis showed that TMEM98 expression was negatively correlated with poly ADP-ribose polymerase expression. Conclusions: This study demonstrates that TMEM98 is low expressed in OC and impacts the prognosis of OC patients. TMEM98 inhibits proliferation and promotes apoptosis and finally exerts a certain tumor-suppressor effect on OC.
Gender Differences in Pain Subtypes among Patients with Parkinson's Disease
Authors: Gao Liang , Yang Yong , Cai Laisheng , Xiong Yuanping
Published: July 2022

Background: To determine the influence of gender on the different pain subtypes experienced by patients with Parkinson’s disease (PD). Methods: Two hundred patients with PD were recruited for this research. Demographic features for all patients were recorded, as well as clinical data on age, disease duration, levodopa equivalent daily dose (LEDD), and scores for Unified Parkinson’s Disease Rating Scale-III (UPDRS III), Hoehn-Yahr Scale (H&Y), King’s Parkinson’s disease Pain Scale (KPPS), Pittsburgh Sleep Quality Index (PSQI), Mini-mental State Examination (MMSE), activities of daily living scale (ADL), Hamilton Depression Rating Scale (HAMD), and Hamilton Anxiety Rating Scale (HAMA) scales. Results: Male and female patients showed no significant differences in terms of age, disease duration, LEDD, H&Y stage, and UPDRS III, HAMD, HAMA, PSQI and ADL scores. Women showed significantly lower MMSE than men, but their KPPS scores were higher (both p < 0.05). Female also showed significantly higher scores for chronic, fluctuation-related pain and oro-facial pain and more discoloration;edema/swelling than males (p < 0.05). Conclusions: Female gender was associated with pain in PD patients, with stronger associations for certain subtypes of PD-related pain.
Endogenous Cannabinoid Receptors Modulate Plasticity at Immature Synapses
Authors: Cheng Jie , Chen Xueling , Xia Hui , Kong Fanli , Wang Li , Zhong Liang , Wu Jiang
Published: July 2022

Background: To explore the mechanism of endocannabinoid cannabinoid receptor 1 (CB1) receptor pathway that regulates synaptic plasticity in the dorsal horn of the spinal cord of rats with neuropathic pain at different ages. Methods: Neonatal, juvenile, and adult male sprague dawley (SD) rats were divided into the spinal nerve preservation injury (SNI), SNI + Anandamide (AEA), SNI + D-AP5, SNI + CNQX, SNI + D-AP5 + AEA, SNI + CNQX + AEA, sham SNI, sham SNI + AEA, sham SNI + D-AP5, sham SNI + CNQX, sham SNI + D-AP5 + AEA, and sham SNI + CNQX + AEA groups, respectively. Paw withdrawal threshold (PWT) and long-term potentiation (LTP) of the spinal dorsal horn PS (field potential) were assessed to judge the spinal cord’s functional state. Immunohistochemical staining and Western blot were conducted to detect CB1 protein levels in the spinal dorsal horn. Results: The LTP response in the spinal cord was alleviated in the SNI + AEA group. After treatment with the N-methyl-D-aspartate (NMDA) receptor blocker D-AP5, the LTP of neonatal A nerve was relieved further. After treatment with the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor blocker CNQX, LTP change in the A nerve was not obvious. The LTP of the A and C nerves were relieved after D-AP5 or CNQX treatment in young and adult animals; however, the blocking effect of CNQX was obvious. The altered levels of PWT and CB1 support these results. Conclusions: The CB1 receptor activation produces analgesia in neonatal rats through NMDA receptor formation for PS inhibitory activity. In juvenile and adult rats, this phenomenon was effectuated through NMDA and AMPA receptors. This difference could be attributed to the varied number of NMDA and/or AMPA receptors activated during development and changes in the NMDA/AMPA receptor ratio.
Effect of Intermittent Exercise on Performance in 3D Multiple Objects Tracking in Children, Young and Older Adults—A Pilot Study
Authors: Klotzbier Thomas Jürgen , Park Soo Yong , Blümer Vera , Schott Nadja
Published: July 2022

Background: Although an extensive body of literature is trying to verify the acute effects of exercise, findings are highly contradictory due to many different study protocols. The number of studies using an intermittent exercise (IE) protocol is limited, especially with regard to comparison across the life span. We examined whether the effects of a HIIE protocol on performance in a perceptual-cognitive task (NeuroTracker® (NT)) differed between children, young adults, and older adults to address this gap. Methods: A total of 36 participants participated in the present study: 12 children (CH, 6 females, 9.83 ± 1.19 years), 12 young adults (YA, 6 females, 23.5 ± 3.55 years), and 12 older adults (OA, 4 females, 66.92 ± 4.08 years). The IE treadmill protocol used in the present study consisted of eleven 30-second intervals at 90% VO2max, interspersed with 2-minute active recovery periods at 50% VO2max. Before and during this exercise protocol, three series of the NeuroTracker® task were performed after 5, 15, and 25 minutes. Results: We observed a significant main effect time and a significant main effect group regarding absolute NT scores and progression during IE. YA had significantly higher absolute NT scores than CH and OA. The normalized perceptual-cognitive task progression was observed in OA and YA but not in CH. YA, in particular, showed progression in the NT performance during IE. Conclusions: The present study confirmed previous findings on age-related differences in NT performance. Based on these findings, the effects of different exercise protocols (e.g., continuous vs. intermittent) seem to be a worthwhile subject for future investigations. Normalized speed thresholds should best capture improvement differences between groups to compare results across studies better, as pre-test values are taken as the baseline.
Application of Carotid Duplex Ultrasonography in the Surveillance of Carotid Artery Stenosis after Neck Irradiation
Authors: Kuo Deng-Yu , Wu Yen-Wen , Hsieh Chen-Hsi , Liao Li-Jen , Shueng Pei-Wei
Published: July 2022

Head and neck cancer (HNC) shares some risk factors with cardiovascular disease. Neck radiotherapy (RT) causes carotid artery injury and stenosis. In HNC patients treated with RT, the prevalence rate of severe (>70%) carotid artery stenosis is >10%, and the cumulative incidence continuously increases over time. There is at least a two-fold risk of cerebrovascular events in these patients compared with the normal population. Carotid artery stenosis is mainly assessed and diagnosed via duplex ultrasonography. Angioplasty and stenting may be recommended to patients who developed severe post-irradiation carotid artery stenosis. This review assessed Taiwanese data that provided some recommendations for HNC patients treated with RT. With consideration of the high prevalence rate of carotid artery stenosis after neck irradiation, duplex ultrasonography should be included in the follow-up workup.
Predictive Value of QRS Fraction for Cardiovascular Death in Patients with Heart Failure: A Prospective Cohort Study in Acute Decompensated Heart Failure (Heb-ADHF)
Authors: Cui Xiaoran , Liu Demin , Geng Xue , Wang Qian , Li Ruibin , Zhou Wenli , Cui Wei
Published: July 2022

Background: The QRS fraction is the ratio of the total amplitude of R waves to the total amplitude of QRS complexes (∑R/QRS) on a 12-lead electrocardiogram. Our group has previously proposed calculation of the QRS fraction as a simple method for estimation of left ventricular ejection fraction. In this study, we explored the ability of the QRS fraction to predict cardiovascular death in patients with heart failure. Methods: The study had a prospective, observational design and collected epidemiological and follow-up data for 1715 patients with heart failure who were inpatients in the Department of Cardiology at the Second Hospital of Hebei Medical University between January 2017 and December 2018. The patients were stratified according to quartile of QRS fraction, namely, lower (<43.8%, Q1 group) middle (43.8%–61.0%, Q2 group), and higher (>61.0%, Q3 group). Results: One thousand and fifty-one (61.28%) of the 1715 patients were male and the median follow-up duration was 261 days (interquartile range 39, 502). There were 341 (19.88%) deaths, including 282 (16.44%) with a cardiovascular cause. The Q1, Q2, and Q3 groups comprised 431 (25.13%), 850 (49.56%), and 434 (25.31%) patients, respectively. There were significant differences in cardiovascular mortality among the three QRS fraction subgroups (p < 0.05). Kaplan-Meier survival curves of different QRS fraction levels showed significant diffference among patients with heart failure, especially among those with preserved ejection fraction (p = 0.025 and 0.031, log-rank test). Cox regression analysis showed that the QRS fraction was independently associated with the risk of cardiovascular death. The risk of cardiovascular death was lower in the Q2 and Q3 groups than in the Q1 group, with respective hazard ratios of 0.668 (95% confidence interval 0.457–0.974) and 0.538 (95% confidence interval 0.341–0.849). Conclusions: The QRS fraction may serve as a prognostic indicator of the long-term risk of cardiovascular death in patients with heart failure, especially those with preserved ejection fraction. Clinical Trial Registry: ChiCTR-POC-17014020.
Oral Anticoagulants in Patients with Atrial Fibrillation and Active Cancer
Authors: Yu Li-Ying , Liu Yen-Wen , Chou Tzu-Yu , Liu Yi-Chia , Su Pei-Fang , Liu Ping-Yen
Published: July 2022

Background: Atrial fibrillation (AF) is associated with an increased risk of heart failure, death and thromboembolism. AF is prevalent in patients with cancer. Although current guidelines suggest the application of oral anticoagulants (OACs) for thromboembolic event prevention in high-risk AF patients, owing to the high thromboembolic and bleeding risks of active-cancer patients, there is no consensus on the use of OACs in such a population. Therefore, we conducted this retrospective cohort study to investigate the applicability of the CHA2DS2-VASc score and to evaluate the efficacy and safety outcomes of OAC therapy in active-cancer patients with AF. Methods: This retrospective cohort study enrolled patients diagnosed with cancer at National Cheng Kung University Hospital between November 2012 and August 2019. The primary outcomes included all-cause mortality, thromboembolic events (stroke/transient ischemic attack and systemic emboli), acute myocardial infarction (AMI), hospitalization for HF and major bleeding events. Results: We enrolled 2429 patients with active cancer. Among these patients, 1060 patients (43.6%) had AF. After 1:2 propensity score matching, 690 cancer patients with AF were enrolled for the final analysis, grouped as follows: 225 patients taking OACs and 465 patients without OAC treatment. The OAC-treated group had lower all-cause mortality than the patients without OAC treatment (all-cause mortality rate in OAC treatment vs. non-OAC treatment: 24.4% vs. 37.4%, hazard ratio 0.58 [95% confidence interval (CI) 0.43–0.78], p < 0.001). However, there was no difference in thromboembolic events, myocardial infarction or heart failure hospitalization between the OAC-treated and non-OAC-treated groups. Importantly, the risk of major bleeding composition (i.e., major gastrointestinal bleeding and intracranial hemorrhage) was similar between these two groups. Moreover, the CHA2DS2-VASc score could not predict thromboembolic events in the enrolled active-cancer patients with AF (OR 1.23, 95% CI 0.98–1.56). Conclusions: OAC treatment may significantly reduce the risk of death, without safety concerns, in active-cancer patients with AF. OAC treatment may not prevent thromboembolic events in patients with active cancer and AF. However, we found that OAC treatment is associated with improved prognosis without increasing the risks of major bleeding, despite several limitations in this study. Further studies are required to determine the optimal use of anticoagulation therapy in this high-risk population.
A Meta-Analysis Comparing Different Oral Anticoagulation for the Treatment of Ventricular Thrombus
Authors: Yang Qing , He Liyun , Quan Xin , Liang Yan
Published: July 2022

Background: Patients with ventricular thrombus (VT) require anticoagulation therapy and it remains unknown that whether non-vitamin K antagonist oral anticoagulants (NOACs) or vitamin K antagonists (VKAs) are more effective. Objective: We aimed to compare the effectiveness and safety of NOACs with VKAs on the rate of thrombus resolution and clinical outcomes. Methods: MEDLINE, PUBMED, EMBASE, Cochrane Library, Web of Science, China National Knowledge Infrastructure Database and Wanfang Database, were searched up to November 22, 2021. The primary outcome was the rate of thrombus resolution, and the secondary outcomes were bleeding, stroke or systemic embolism (SSE), stroke and all-cause death. Odds ratio (OR) and 95% confidential intervals (CI) were used for the pooled results. Results: Eighteen studies with 1755 participants (NOACs, n = 607; VKAs, n = 1148) were included. There were no significant differences in thrombus resolution (OR 0.92, 95% CI 0.68–1.23, p = 0.558), bleeding (OR 0.85, 95% CI 0.54–1.35, p = 0.496), SSE (OR 0.77, 95% CI 0.41–1.43, p = 0.401), stroke (OR 0.65, 95% CI 0.29–1.49, p = 0.312) or all-cause death (OR 1.02, 95% CI 0.63–1.67, p = 0.925) between NOACs and VKAs. Subgroup analyses showed a statistics difference in thrombus resolution between NOACs and VKAs among studies which enrolled patients with or without dabigatran (Yes: OR 0.80, 95% CI 0.59–1.08; No: OR 1.48, 95% CI 1.00–2.19; p = 0.01), while no significances were observed according to baseline characteristics. Conclusions: Our findings showed that NOACs were comparable to VKAs in thrombus resolution as well as clinical outcomes. In studies that enrolled patients without dabigatran, the thrombus resolution seemed to be greater in NOACs group than VKAs group. And in different proportion of baseline left ventricular ejection fraction, history of ischemic cardiomyopathy and combination with antiplatelet, the thrombus resolution among the two groups remained similar.
The Association between Leisure-Time Physical Activity Intensity and Duration with the Risk of Mortality in Patients with Chronic Kidney Disease with or without Cardiovascular Diseases
Authors: Li Ning , Hong Ruoyang , Zhou Weiguo , Zhong Jingchen , Kan Mingyun , Zheng Yawei , Zhou Enchao , Sun Wei , Zhang Lu
Published: July 2022

Introduction: For chronic kidney disease (CKD) patients with or without cardiovascular diseases, the associations between leisure-time physical activity intensity (LTPA) and daily exercise time with mortality risk remain unclear. Method: This study enrolled 3279 CKD patients from National Health and Nutrition Examination Survey (NHANES) 2007–2014 survey. Patients were grouped into different groups according to LTPA intensity (none, moderate, vigorous) and duration (0 min, 0–30 min, 30–60 min, >60 min). We selected the confounders based on their connections with the outcomes of interest or a change in effect estimate of more than 10%. Multivariable-adjusted Cox proportional hazards models were used to examine the associations between LTPA and mortality. The three-knot cubic spline (10, 50, and 90%) was employed to investigate the relationship between the dose of LTPA duration and all-cause death. Patients were divided into different groups according to cardiovascular diseases (CVD). Results: A total of 564 all-cause death were recorded in this study. Multivariable Cox regression showed that moderate LTPA was associated with a reduced risk of mortality by 38% (hazard ratio (HR): 0.62, 95% confidence interval (CI): 0.44–0.88) in CKD patients, while vigorous LTPA did not have evident survival benefits (HR: 0.91, 95% CI: 0.46–2.64). Subgroups analysis demonstrated that those who engaged in moderate LTPA have a significantly lower risk of mortality (HR: 0.67, 95% CI: 0.47–0.95) in patients without CVD, while patients complicated with CVD did not benefit from the practice (HR: 0.61, 95% CI: 0.37–1.02). Physical exercise for more than 30 minutes was associated with a lower risk of mortality in general CKD patients (30–60 min: HR: 0.23, 95% CI: 0.09–0.58, >60 min: HR: 0.23, 95% CI: 0.08–0.63) and those without CVD (30–60 min/d: HR: 0.32, 95% CI: 0.12–0.83, >60 min/d: HR: 0.20, 95% CI: 0.06–0.71); however, this positive outcome was not seen in patients complicated with CVD (30–60 min/d: HR: 0.67, 95% CI: 0.11–4.04, >60 min/d: HR: 1.14, 95% CI: 0.14–9.11). Conclusions: Moderate LTPA for more than 30 minutes is associated with a reduced risk of mortality in general CKD patients and those without CVD. However, LTPA did not reduce the risk of mortality in CKD patients complicated with CVD.
Obstructive Shock, from Diagnosis to Treatment
Authors: Zotzmann Viviane , Rottmann Felix A. , Müller-Pelzer Katharina , Bode Christoph , Wengenmayer Tobias , Staudacher Dawid L.
Published: July 2022

Shock is a life threatening pathological condition characterized by inadequate tissue oxygen supply. Four different subgroups of shock have been proposed according to the mechanism causing the shock. Of these, obstructive shock is characterized by reduction in cardiac output due to noncardiac diseases. The most recognized causes include pulmonary embolism, tension pneumothorax, pericardial tamponade and aortic dissection. Since obstructive shock typically cannot be stabilized unless cause for shock is resolved, diagnosis of the underlying disease is eminent. In this review, we therefore focus on diagnosis of obstructive shock and suggest a structured approach in three steps including clinical examination, ultrasound examination using the rapid ultrasound in shock (RUSH) protocol and radiological imaging if needed.
Análisis espacial del ciberfraude al comercio electrónico: consideraciones en agenda política Tamaulipeca
Authors: Domínguez Arteaga Rosa Amelia , Vera Vázquez Rodrigo
Published: July 2022

En un acercamiento hacia la comprensión y atención de la ciberdelincuencia en México, el objetivo es realizar un recuento de las técnicas utilizadas por los ciberdelincuentes, y determinar la distribución espacial del ciberfraude contra el comercio electrónico en Tamaulipas. Metodológicamente se realizó un análisis de las llamadas a la Policía Federal por ciberdelitos de 2018 a 2019 aplicando el coeficiente de localización. Los resultados mostraron que existe concentración de llamadas en Nayarit, Jalisco y Chihuahua. Tamaulipas se colocó como un lugar propenso para este ciberdedelito en el contexto nacional. Las técnicas utilizadas por los ciberdelincuentes fueron principalmente el uso de las redes sociales para robar contraseñas. Se concluye que se requiere de políticas públicas nacionales y locales que atiendan el aumento de los ciberdelitos y la concentración de estos, como fue el caso de Tamaulipas.
Estrés laboral docente, e-learning y tiempos de COVID-19
Authors: Álvarez Silva Luis Antonio , Herrera López Pablo Samuel , Lániz Vargas Christopher Alcides , González Zhagñay Javier Oswaldo
Published: July 2022

La presente investigación tiene como objetivo analizar el nivel de estrés laboral al que estuvieron expuestos los docentes de varios centros educativos, y quienes tuvieron que acoplarse a la modalidad e-learning a consecuencia de la pandemia provocada por el COVID- 19en el año 2020. El diseño de estudio es no experimental de tipología transversal y alcance descriptivo. Para su consecución se utilizó la prueba Karasek, la misma que mide la variable de estrés laboral y que en este ejercicio presentó un adecuado nivel de consistencia interna (α = 0.85). La muestra estuvo conformada por 272 docentes de diferentes unidades académicas, en quienes se efectuó el levantamiento de información en meses pico de crisis sanitaria. Como conclusión se obtuvo que la adaptación a la nueva modalidad, las altas horas de conectividad, la falta de planificación estratégica, y las noticias negativas en general denotaron un alto índice de estrés laboral.
Tasawuf Dari Tradisi Budaya
Authors: Kurniawan M Agus
Published: July 2022

A change of paradigm (shifting paradigm) of dichotomous-atomistic toward integrative paradigm bid-interkonektif, interconnectivity and sensitivity between different disciplines need to obtain a priority basis and need to be built and developed. In other words the need to foster the scientific ethos that emphasizes interdisiplinary, sensitivity and interconnectivity between various public and religious disciplines. As above of the various approaches of science the science of psychology, philosophy, sociology, anthropology, and phenomenology used to approach religion separately, then it is the time approaches interdisiplinary, interconnectivity, and sensitivity interdisciplinary Such a view underlined the importance of the framework which was built in the fundamentals of the doctrine and the fundamental value that is contained in the Quran and al-Sunnah as the principal source
Social Sharing of Emotion During the Collective Crisis of COVID-19
Authors: Ma Gloria Wai Shan , Schöne Jonas , Parkinson Brian
Published: July 2022

We collected data from two sources — social media and online questionnaires — to investigate the emotional consequences of social sharing during the COVID-19 pandemic. Study 1 tracked and analysed sentiment of tweets posted over the course of a month in the crisis period and found that users who tweeted more frequently about COVID-19 expressed decreasing negative sentiment and increasing positive sentiment over time. Granger-causality tests confirmed that this association was better interpreted in the forward direction (sharing levels predicting sentiment) than in the reverse direction (sentiment predicting sharing levels). Study 2 focused on immediate emotional consequences of sharing COVID-related events and found that participants reported improved overall affect about an event to after sharing it, especially when that event was a personal experience rather than a news story. Reported positive feelings about both kinds of event were also significantly higher after sharing. Taken together, both studies suggested that social sharing is linked with emotional relief and may therefore help people to deal with their negative experiences during a persistent collective crisis.
Balance is remaining in your body. 마찰이 부족한 환경에서 균형 잡은 채로 잠들면 균형이 남는다.
Authors: Choi HyungBeom
Published: July 2022

Theory from Theory Discoverer through Intuition. 직관을 통해 발견한 이론.
THE DANGERS OF FREE ASSOCIATION IN YOUTH
Authors: Saputra Pramudya
Published: July 2022

Promiscuity in teenagers is very widespread in today's era. Free association is a deviant act that crosses the boundaries of the norms that exist in our lives. Adolescents are individuals whose emotions are very vulnerable, lack of knowledge and invitations from friends who hang out freely make their potential decrease. the younger generation in advancing the times. The method I use is the interview method and approach to teenagers by giving broad directions about the dangers of promiscuity. Avoid actions that deviate from the norm with strong faith.
Algorithmic Technique for Computation of Binomial Expansions and Geometric Series of Multiples of Powers of Two
Authors: Annamalai Chinnaraji
Published: July 2022

This paper presents algorithmic technique for computing the summation of binomial expansions and geometric series of multiples of powers of two. This computing technique is a methodological advance which is useful for researchers who are working in science, economics, engineering, computation, and management.
Facial Expression Recognition in Videos Using Dynamic Local Binary Patterns
Authors: Bafandehkar Akram , Karimi-Rouzbahani Hamid
Published: July 2022

We propose a novel fully automatic approach for facial expression recognition in videos. For that purpose, we focus on face regions, such as eyes and mouth, which are mostly affected by variation in facial expressions. Initially, the face region is detected using Viola and Jones’ face detection method and the key parts of the face are located based on the key points extracted through pictorial structure analysis. Next, the image sequence is transferred to the motion vector domain using Lucas-Kanade algorithm. Later, the key parts of faces are separated using pictorial structures and a novel heuristic weighted Local Binary Pattern on Three Orthogonal Planes (LBP-TOP) is applied on each part to extract the most informative features. Finally, a combination of Support Vector Machine classifiers is used to classify facial expressions. The effectiveness of proposed method is evaluated on the Cohn-Kanade facial expression dataset. Our proposed method, , provided features that reached an average recognition accuracy of 98.48% in 10-fold cross-validation which improved the basic LBP-TOP method by 1.13%. Advantages of our approach is its robustness to rotation and gray-scale changes leading to high accuracy as well as being fully automatic.
A Bayesian Reanalysis of a Trial of Psilocybin versus Escitalopram for Depression
Authors: Nayak Sandeep Manel , Bari Bilal A , Yaden David Bryce , Spriggs Meg J , Rosas Fernando , Peill Joseph M , Giribaldi Bruna , Erritzoe David , Nutt David , Carhart-Harris Robin
Published: July 2022

Objectives: To perform a Bayesian reanalysis of a recent trial of psilocybin (COMP360) versus escitalopram for Major Depressive Disorder (MDD) in order to provide a more informative interpretation of the indeterminate outcome of a previous frequentist analysis.Design: Reanalysis of a two-arm double-blind placebo controlled trial.Participants: Fifty-nine patients with MDD.Interventions: Two doses of psilocybin 25mg and daily oral placebo versus daily escitalopram and 2 doses of psilocybin 1mg, with psychological support for both groups.Outcome measures: Quick Inventory of Depressive Symptomatology–Self-Report (QIDS SR-16), and three other depression scales as secondary outcomes: HAMD-17, MADRS, and BDI-1A.Results: Using Bayes factors and ‘skeptical priors’ which bias estimates towards zero, for the hypothesis that psilocybin is superior by any margin, we found indeterminate evidence for QIDS SR-16, strong evidence for BDI-1A and MADRS, and extremely strong evidence for HAMD-17. For the stronger hypothesis that psilocybin is superior by a ‘clinically meaningful amount’ (using literature defined values of the minimally clinically important difference), we found moderate evidence against it for QIDS SR-16, indeterminate evidence for BDI-1A and MADRS, and moderate evidence supporting it for HAMD-17. Furthermore, across the board we found extremely strong evidence for psilocybin’s non-inferiority versus escitalopram. These findings were robust to prior sensitivity analysis.Conclusions: This Bayesian reanalysis supports the following inferences: 1) that psilocybin did indeed outperform escitalopram in this trial, but not to an extent that was clinically meaningful—-and 2) that psilocybin is almost certainly non-inferior to escitalopram. The present results provide a more precise and nuanced interpretation to previously reported results from this trial, and support the need for further research into the relative efficacy of psilocybin therapy for depression with respect to current leading treatments.