bluuebunny/crossref_metadata_2025 huggingface dataset:
PiPred – a deep-learning method for prediction of π-helices in protein sequences
Authors: Ludwiczak Jan , Winski Aleksander , da Silva Neto Antonio Marinho , Szczepaniak Krzysztof , Alva Vikram , Dunin-Horkawicz Stanislaw
Published: May 2019

Canonical π-helices are short, relatively unstable secondary structure elements found in proteins. They comprise seven or more residues and are present in 15% of all known protein structures, often in functionally important regions such as ligand- and ion-binding sites. Given their similarity to α-helices, the prediction of π-helices is a challenging task and none of the currently available secondary structure prediction methods tackle it. Here, we present PiPred, a neural network-based tool for predicting π-helices in protein sequences. By performing a rigorous benchmark we show that PiPred can detect π-helices with a per-residue precision of 48% and sensitivity of 46%. Interestingly, some of the α-helices mispredicted by PiPred as π-helices exhibit a geometry characteristic of π-helices. Also, despite being trained only with canonical π-helices, PiPred can identify 6-residue-long α/π-bulges. These observations suggest an even higher effective precision of the method and demonstrate that π-helices, α/π-bulges, and other helical deformations may impose similar constraints on sequences. PiPred is freely accessible at: https://toolkit.tuebingen.mpg.de/#/tools/quick2d. A standalone version is available for download at: https://github.com/labstructbioinf/PiPred, where we also provide the CB6133, CB513, CASP10, and CASP11 datasets, commonly used for training and validation of secondary structure prediction methods, with correctly annotated π-helices.
Systemic inflammation is associated with malaria and preterm birth in women living with HIV on antiretrovirals and co-trimoxazole
Authors: McDonald Chloe R. , Weckman Andrea M. , Conroy Andrea L. , Olwoch Peter , Natureeba Paul , Kamya Moses R. , Havlir Diane V. , Dorsey Grant , Kain Kevin C.
Published: May 2019

Women living with HIV (WLHIV) have an increased risk of malaria in pregnancy (MiP). It is unclear if MiP in WLHIV causes a systemic inflammatory response and increases the risk of adverse birth outcomes, especially for women receiving antiretroviral therapy (ART) and daily trimethoprim-sulfamethoxazole (TMP/SXT). We analyzed repeated plasma samples in a cohort of malaria-exposed Ugandan WLHIV receiving ART and daily TMP/SXT to examine changes in inflammatory markers across pregnancy and their association with birth outcomes. Concentrations of CHI3L1, CRP, IL-18BP, IL-6, sICAM-1, and sTNFR2 were quantified by ELISA in 1115 plasma samples collected over pregnancy from 326 women. MiP was associated with increased sTNFR2, sICAM-1 and IL-18BP concentrations across pregnancy. Women who delivered preterm had elevated concentrations of sTNFR2 and altered levels of IL-6 during pregnancy. Women with sTNFR2 concentrations in the highest quartile within 6 weeks of delivery had an increased relative risk of preterm birth. Our results indicate that despite daily TMP/SXT, MiP in WLHIV induced a systemic inflammatory response that was associated with an increased risk of preterm birth. These findings highlight the need for additional strategies to protect WLHIV from malaria infection in pregnancy to promote healthy outcomes for mother and child.
Synthesis and in vivo characterization of 18F-labeled difluoroboron-curcumin derivative for β-amyloid plaque imaging
Authors: Kim Hyunjung , Im Young Hoon , Ahn Jinhee , Yang Jehoon , Choi Joon Young , Lee Kyung-Han , Kim Byung-Tae , Choe Yearn Seong
Published: May 2019

Positron emission tomography imaging of β-amyloid (Aβ) plaques has proven useful in the diagnosis of Alzheimer’s disease. A previous study from our group showed that 4′-O-[18F]fluoropropylcurcumin has poor brain permeability, which is thought to be due to its rapid metabolism. In this study, we synthesized difluoroboron complexes of fluorine-substituted curcumin derivatives (1–4) and selected one of them based on the in vitro binding assays. The selected ligand 2 was found to distinctively stain Aβ plaques in APP/PS1 transgenic mouse brain sections. Radioligand [18F]2 was synthesized via a two-step reaction consisting of [18F]fluorination and subsequent aldol condensation. Biodistribution and metabolism studies indicated that radioligand [18F]2 was converted to polar radioactive products and trapped in the normal mouse brain. In contrast, optical images of mice acquired after injection of 2 showed moderate fluorescence signal intensity in the mouse brain at 2 min with a decrease in the signal within 30 min. In the ex vivo optical images, the fluorescence signals in major tissues disappeared within 30 min. Taken together, these results suggest that [18F]2 may be converted to polar 18F-labeled blue-shifted fluorescent products. Further structural modifications are thus needed to render the radioligand metabolically stable.
Author Correction: Pollinator-mediated selection on flowering phenology and floral display in a distylous herb Primula alpicola
Authors: Chen Lingling , Zhang Bo , Li Qingjun
Published: May 2019

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Author Correction: The Plasmodium falciparum male gametocyte protein P230p, a paralog of P230, is vital for ookinete formation and mosquito transmission
Authors: Marin-Mogollon Catherin , van de Vegte-Bolmer Marga , van Gemert Geert-Jan , van Pul Fiona J. A. , Ramesar Jai , Othman Ahmad Syibli , Kroeze Hans , Miao Jun , Cui Liwang , Williamson Kim C. , Sauerwein Robert W. , Janse Chris J. , Khan Shahid M.
Published: May 2019

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Precision oncology of lung cancer: genetic and genomic differences in Chinese population
Authors: Shen Hongbing , Zhu Meng , Wang Cheng
Published: May 2019

Knowledge of the lung cancer genome has experienced rapid growth over the past decade. Genome-wide association studies and sequencing studies have identified dozens of genetic variants and somatic mutations implicated in the development of lung cancer in both Chinese and Caucasian populations. With the accumulating evidence, heterogeneities in lung cancer susceptibility were observed in different ethnicities. In this review, the progress on germline-based genetic variants and somatic-based genomic mutations associated with lung cancer and the differences between Chinese and Caucasian populations were systematically summarized. In the analysis of the genetic predisposition to lung cancer, 6 susceptibility loci were shared by Chinese and Caucasian populations (3q28, 5p15, 6p21, 9p21.3, 12q13.13 and 15q25), 14 loci were specific to the Chinese population (1p36.32, 5q31.1, 5q32, 6p21.1, 6q22.2, 6p21.32, 7p15.3, 10p14, 10q25.2, 12q23.1, 13q22, 17q24.3, 20q13.2, and 22q12), and 12 loci were specific to the Caucasian population (1p31.1, 2q32.1, 6q27, 8p21.1, 8p12, 10q24.3, 11q23.3, 12p13.33, 13q13.1, 15q21.1, 20q13.33 and 22q12.1). In the analysis of genomic and somatic alterations, different mutation rates were observed for EGFR (Chinese: 39–59% vs. TCGA: 14%), KRAS (Chinese: 7–11% vs. TCGA: 31%), TP53 (Chinese: 44% vs. TCGA: 53%), CDKN2A (Chinese: 22% vs. TCGA: 15%), NFE2L2 (Chinese: 28% vs. TCGA: 17%), STK11 (Chinese: 4–7% vs. TCGA: 16%), KEAP1 (Chinese: 3–5% vs. TCGA: 18%), and NF1 (Chinese: <2% vs. TCGA: 12%). In addition, frequently amplified regions encompassing genes involved in cytoskeletal organization or focal adhesion were identified only in Chinese patients. These results provide a comprehensive description of the genetic and genomic differences in lung cancer susceptibility between Chinese and Caucasian populations and may contribute to the development of precision medicine for lung cancer treatment and prevention.
Detecting false-positive disease references in veterinary clinical notes without manual annotations
Authors: Kennedy Noel , Brodbelt Dave C. , Church David B. , O’Neill Dan G.
Published: May 2019

Clinicians often include references to diseases in clinical notes, which have not been diagnosed in their patients. For some diseases terms, the majority of disease references written in the patient notes may not refer to true disease diagnosis. These references occur because clinicians often use their clinical notes to speculate about disease existence (differential diagnosis) or to state that the disease has been ruled out. To train classifiers for disambiguating disease references, previous researchers built training sets by manually annotating sentences. We show how to create very large training sets without the need for manual annotation. We obtain state-of- the-art classification performance with a bidirectional long short-term memory model trained to distinguish disease references between patients with or without the disease diagnosis in veterinary clinical notes.
Structural and biochemical analyses of the nuclear pore complex component ELYS identify residues responsible for nucleosome binding
Authors: Kobayashi Wataru , Takizawa Yoshimasa , Aihara Maya , Negishi Lumi , Ishii Hajime , Kurumizaka Hitoshi
Published: May 2019

The nuclear pore complex embedded within the nuclear envelope is the essential architecture for trafficking macromolecules, such as proteins and RNAs, between the cytoplasm and nucleus. The nuclear pore complex assembly occurs on chromatin in the post-mitotic phase of the cell cycle. ELYS (MEL-28/AHCTF1) binds to the nucleosome, which is the basic chromatin unit, and promotes assembly of the complex around the chromosomes in cells. Here we show that the Arg-Arg-Lys (RRK) stretch of the C-terminal ELYS region plays an essential role in the nucleosome binding. The cryo-EM structure and the crosslinking mass spectrometry reveal that the ELYS C-terminal region directly binds to the acidic patch of the nucleosome. These results provide mechanistic insight into the ELYS-nucleosome interaction, which promotes the post-mitotic nuclear pore complex formation around chromosomes in cells.
The function of PROTOPORPHYRINOGEN IX OXIDASE in chlorophyll biosynthesis requires oxidised plastoquinone in Chlamydomonas reinhardtii
Authors: Brzezowski Pawel , Ksas Brigitte , Havaux Michel , Grimm Bernhard , Chazaux Marie , Peltier Gilles , Johnson Xenie , Alric Jean
Published: May 2019

In the last common enzymatic step of tetrapyrrole biosynthesis, prior to the branching point leading to the biosynthesis of heme and chlorophyll, protoporphyrinogen IX (Protogen) is oxidised to protoporphyrin IX (Proto) by protoporphyrinogen IX oxidase (PPX). The absence of thylakoid-localised plastid terminal oxidase 2 (PTOX2) and cytochrome b6f complex in the ptox2 petB mutant, results in almost complete reduction of the plastoquinone pool (PQ pool) in light. Here we show that the lack of oxidised PQ impairs PPX function, leading to accumulation and subsequently uncontrolled oxidation of Protogen to non-metabolised Proto. Addition of 3(3,4-Dichlorophenyl)-1,1-dimethylurea (DCMU) prevents the over-reduction of the PQ pool in ptox2 petB and decreases Proto accumulation. This observation strongly indicates the need of oxidised PQ as the electron acceptor for the PPX reaction in Chlamydomonas reinhardtii. The PPX-PQ pool interaction is proposed to function as a feedback loop between photosynthetic electron transport and chlorophyll biosynthesis.
P38 inhibition reverses TGFβ1 and TNFα-induced contraction in a model of proliferative vitreoretinopathy
Authors: Schiff Lauren , Boles Nathan C. , Fernandes Marie , Nachmani Bar , Gentile Ronald , Blenkinsop Timothy A.
Published: May 2019

Proliferative vitreoretinopathy (PVR) is a metaplasia in the vitreous of the eye manifested by the transformation of retinal pigment epithelial (RPE) cells and the development of contracting epiretinal membranes (ERM), which lead to retinal detachment and vision loss. While TGFβ1 and TNFα have been associated with PVR, here we show that these cytokines act synergistically to induce an aggressive contraction phenotype on adult human (ah)RPE. Connected RPE detach upon contraction and form motile membranes that recruit more cells. TGFβ1 and TNFα (TNT)-induced contracting membranes uniquely express muscle and extracellular rearrangement genes. Whole transcriptome RNA sequencing of patient-dissected PVR membranes showed activation of the p38-MAPK signaling pathway. Inhibition of p38 during TNT treatment blocks ahRPE transformation and membrane contraction. Furthermore, TNT-induced membrane contractility can be reversed by p38 inhibition after induction. Therefore, targeting the p38-MAPK pathway may have therapeutic benefits for patients with PVR even after the onset of contracting ERMs.
Egg Protein in Sports Nutrition
Authors: Martinez I. G. , McKenna C. F. , Burd N. A.
Published: May 2019

Dietary protein, in particular, is related to various processes, such as muscle remodeling, augmenting glycogen re-synthesis under certain conditions, energy production and maintenance of non-muscle structural tissues, all of which impact physical performance. More importantly, provision of adequate and high-quality protein after a bout of exercise supports the whole-body and the muscle adaptive response to exercise. As such, protein recommendations for athletes have been shown to be higher than what is recommended for the general public and are estimated to be ∼1.2 to 2.0 g−1 kg body weight−1 day−1. In terms of meeting these protein recommendations, isolated protein supplements are commonly ingested by athletes. The popularity of isolated protein sources among athletes can be primarily attributed to convenience as opposed to being superior in terms of stimulating an exercise-adaptive response when compared to protein-dense food ingestion. However, there are limited studies available on the effect of post-exercise ingestion of protein-rich whole food as compared to protein supplements. In the sports nutrition realm, the potential of protein-rich and nutrient-dense whole foods such as eggs has yet to be fully examined. However, given the robust nutritional profile, low cost and culinary versatility of eggs, athletes would benefit from including these in their usual diet and/or as a targeted post-exercise nutritional strategy.
Modulation of Inflammation by Egg Components
Authors: Andersen C. J. , Van Dyke A. R.
Published: May 2019

It has been well established that eggs, primarily derived from chickens, can be categorized as a functional food that contains a wide range of bioactive components. When provided as a whole food or in isolated forms, egg-derived bioactive compounds, such as glycerophospholipids, sphingolipids, cholesterol, proteins, peptides, and carotenoids, have been shown to impact lipid metabolism as well as antioxidant, inflammatory, and immunomodulatory pathways. Accordingly, egg intake has been shown to impact biomarkers and clinical outcomes of acute and chronic inflammatory diseases, including cardiovascular disease, type 2 diabetes mellitus, metabolic syndrome, and tuberculosis. In this chapter, we highlight recent findings that elucidate how egg intake affects markers and pathways of inflammation in human populations. Further, we review molecular mechanisms by which egg-derived compounds regulate inflammatory responses.
Antiviral Properties of Egg Components
Authors: Zhang Hua , Mine Yoshinori
Published: May 2019

Eggs contain high-quality proteins and lipids as well as valuable minerals, carbohydrates and vitamins. Avian eggs contain the basic elements for life, and for new life, and therefore many egg compounds have biological activity. After the recent unlocking of eggs' secrets, eggs are considered one of the most attractive sources of bioactive and functional foods for health promotion beyond traditional nutritional foods. This chapter particularly focuses on the antiviral properties of specific egg components. The antiviral properties of egg protein and its derived peptides or oligosaccharides in egg white and yolk are highlighted. Numerous egg-derived bioactive components, such as ovomucin, ovotransferrin, lysozyme, cystatin, IgY and sialic acid derivatives, are summarized for their effective antiviral activity, particularly against gastroenteric and influenza viruses. Following recent advances in omics technology along with the development of novel quantitative structure–biological activity models, the hen egg remains one of the most explored sources of bioactive proteins or peptides, with a particular focus on the mechanisms underlying their health-promoting effects.
Bioactive Egg Proteins
Authors: Nolasco Emerson , Guha Snigdha , Majumder Kaustav
Published: May 2019

The nutritional excellence of chicken egg is derived from its task as a life-giving medium, supplying the necessary nutrients to the hen's embryo while protecting it from external threats. Additionally, egg proteins possess unique biological activities above and beyond their known functional and nutritional roles. In the last few decades, extensive research has been done to evaluate the various biological activities of egg proteins and protein-derived peptides. Egg proteins and protein-derived peptides have been attributed to diverse biological activities, the most well-known being their antimicrobial properties. However, egg proteins and peptides have been shown to have other biological activities, such as antihypertensive, antioxidant, anticancer, immunomodulatory, and protease inhibitory activity. Egg-derived bioactive proteins have had a relevant scientific impact and exhibit promising applicability as an ingredient for the development of functional foods and nutraceuticals. However, it is critical to understand the effects of these proteins in signaling pathways to delineate their molecular mechanisms of action. Further studies are required to fill the current knowledge gaps. Therefore, the purpose of the chapter is to illustrate the present knowledge of the bioactivity of different egg proteins and their physiological effects.
Bioactivities and Mechanisms of Egg Protein-derived Peptides
Authors: Liao Wang , Wu Jianping
Published: May 2019

Food protein-derived bioactive peptides have gained substantial interest during recent decades owing to their potential in modulating various physiological functions. As a high-quality, affordable and universally accepted protein source, egg is an ideal candidate for identification of numerous bioactive peptides. Extensive research has been carried out on identification and activity characterization of antihypertensive peptides, antidiabetic peptides, anticancer peptides, immunomodulatory peptides and antioxidant peptides. Mechanistic study of egg protein-derived bioactive peptides revealed the complexity of actions of these peptides as they may play multiple roles in regulating physiological functions, which warrants further investigation. The objectives of this book chapter are to summarize recent research progress on egg peptides and to identify the research gaps to translate the laboratory research into real-world applications of egg peptides as functional foods and nutraceuticals. Future research is expected to establish biologically relevant methods to replace chemical-based activity assay, to establish the efficacy and safety of egg peptides in human trials, to characterize peptide and cell cross-talks, to explore the multi-bioactivity of egg peptides, and to study the interactions between egg peptides and gut microbiota.
A spermine-conjugated lipophilic Pt(iv) prodrug designed to eliminate cancer stem cells in ovarian cancer
Authors: Stilgenbauer Morgan , Jayawardhana Amarasooriya M. D. S. , Datta Payel , Yue Zhizhou , Gray Michael , Nielsen Frederick , Bowers David J. , Xiao Haihua , Zheng Yao-Rong
Published: May 2019

A spermine-conjugated lipophilic Pt(iv) prodrug is designed to induce mitochondrial damage and eliminate ovarian cancer stem cells.
pH-sensitive loaded retinal/indocyanine green micelles as an “all-in-one” theranostic agent for multi-modal imaging in vivo guided cellular senescence-photothermal synergistic therapy
Authors: Zhu Lipeng , Li Ping , Gao Duyang , Liu Jie , Liu Yubin , Sun Chen , Xu Mengze , Chen Xin , Sheng Zonghai , Wang Ruibing , Yuan Zhen , Cai Lintao , Ma Yifan , Zhao Qi
Published: May 2019

pH-sensitive loaded retinal/indocyanine green (ICG) micelles were developed for cellular senescence-photothermal synergistic therapy.
Disorder in molecular crystals justified with the help of statistical mechanics: a case of two enantiomer solid solutions
Authors: Rekis Toms
Published: May 2019

An elegant statistical mechanics approach has been exploited in combination with accurate quantum chemical calculations to justify the disorder in two previously reported racemic solids.
The molecular mechanism of structural changes in the antimicrobial peptide CM15 upon complex formation with drug molecule suramin: a computational analysis
Authors: Kohut Gergely , Sieradzan Adam , Zsila Ferenc , Juhász Tünde , Bősze Szilvia , Liwo Adam , Samsonov Sergey A. , Beke-Somfai Tamás
Published: May 2019

Stabilization of helical conformations of CM15 upon interactions with suramin.
Computational prediction of pentadentate iron and cobalt complexes as a mimic of mono-iron hydrogenase for the hydrogenation of carbon dioxide to methanol
Authors: Wang Wan , Qiu Bing , Yang Xinzheng
Published: May 2019

A bio-inspired computational design of a pentadentate cobalt complex as a mimic of the active center of [Fe]-hydrogenase for the hydrogenation of carbon dioxide to methanol.
Short-time deep eutectic solvent pretreatment for enhanced enzymatic saccharification and lignin valorization
Authors: Guo Zongwei , Zhang Qilin , You Tingting , Zhang Xun , Xu Feng , Wu Yuying
Published: May 2019

In the present study, two kinds of deep eutectic solvents (DESs) were facilely prepared and adopted to drastically disturb the recalcitrance of corncobs for further boosting sugar yields and obtaining valorized lignin by-products while reducing treatment times.
Synthesis of functionalized 3-isochromanones via metal-free intramolecular alkoxylation-initiated cascade cyclization
Authors: Zhang Ying-Qi , Zhu Xin-Qi , Xu Yin , Bu Hao-Zhen , Wang Jia-Le , Zhai Tong-Yi , Zhou Jin-Mei , Ye Long-Wu
Published: May 2019

A metal-free intramolecular alkoxylation-initiated cascade cyclization of allyl ether-tethered ynamides has been developed, leading to functionalized 3-isochromanones in high yields.
Enzymatic synthesis of new hepoxilins and trioxilins from polyunsaturated fatty acids
Authors: Lee In-Gyu , An Jung-Ung , Ko Yoon-Joo , Park Jin-Byung , Oh Deok-Kun
Published: May 2019

Hepoxilins (HXs) and trioxilins (TrXs) are lipid mediators that regulate diverse physiological processes at trace amounts in humans.
A comprehensive profile of the tilapia (Oreochromis niloticus) circular RNA and circRNA–miRNA network in the pathogenesis of meningoencephalitis of teleosts
Authors: Fan Bolin , Chen Funuan , Li Yuan , Wang Zhongliang , Wang Zhiwen , Lu Yishan , Wu Zaohe , Jian Jichang , Wang Bei
Published: May 2019

The pathogenesis of tilapia meningoencephalitis is still unclear, where the involvement of circRNA is considered for its active role as a “miRNA sponge”.
Correction: Cold plasma gas loaded microbubbles as a novel ultrasound contrast agent
Authors: Dong Feihong , Zhang Jiabin , Wang Kaile , Liu Zhengxin , Guo Jinsong , Zhang Jue
Published: May 2019

Correction for ‘Cold plasma gas loaded microbubbles as a novel ultrasound contrast agent’ by Feihong Dong et al., Nanoscale, 2019, 11, 1123–1130.
Post-genomic approach based discovery of alkylresorcinols from a cricket-associated fungus, Penicillium soppi
Authors: Kaneko Akiho , Morishita Yohei , Tsukada Kento , Taniguchi Tohru , Asai Teigo
Published: May 2019

A highly reducing polyketide synthase (HR-PKS) collaborates with a type III PKS to produce alkylresorcinols via unusual biosynthetic machinery.
A hexameric resorcinarene capsule as a hydrogen bonding catalyst in the conjugate addition of pyrroles and indoles to nitroalkenes
Authors: Gambaro Stefania , De Rosa Margherita , Soriente Annunziata , Talotta Carmen , Floresta Giuseppe , Rescifina Antonio , Gaeta Carmine , Neri Placido
Published: May 2019

A hexameric resorcinarene capsule (C) acts as a hydrogen bonding catalyst for the addition of nitroalkenes to pyrroles and indoles.
Active targeting drug-gold nanorod hybrid nanoparticles for amplifying photoacoustic signal and enhancing anticancer efficacy
Authors: Ge Xiaoguang , Chen Bin , Liu Tianji , Wei Lan , Tong Lingling , Ma Qingjie , Gao Shi , Song Jibin
Published: May 2019

We developed a multifunctional metal–organic hybrid nanoparticle with enhanced photoacoustic imaging performance and specific chemo-photothermal cancer therapy.
Effect of interfacial defects on the electronic properties of graphene/g-GaN heterostructures
Authors: Deng Zhongxun , Wang Xianhui , Cui Jie
Published: May 2019

To gain deep insights into their interactions, the effects of interfacial defects on the structural and electronic properties of graphene/g-GaN heterostructures were investigated by using first-principles calculations.
Incorporating polyoxometalates and organic ligands to pursue 3d–4f heterometallic clusters: a series of {Cr4Ln4} clusters stabilized by phthalic acid and [SiW12O40]4−
Authors: Gu Ya-Nan , Zhao Dan , Yu Hao , Ge Rui , Li Zhong , Tian Chong-Bian , Li Xin-Xiong , Sun Yan-Qiong , Zheng Shou-Tian
Published: May 2019

By introduction of trilacunary Keggin-type polyoxometalate to the hydrothermal reaction system of Cr3+, Ln3+ and phthalic acid, a series of novel {Cr4Ln4} heterometallic clusters have been obtained.
Laser wavelength modulated pulsed laser ablation for selective and efficient production of graphene quantum dots
Authors: Kang Sukhyun , Ryu Jeong Ho , Lee Byoungsoo , Jung Kyung Hwan , Shim Kwang Bo , Han Hyuksu , Kim Kang Min
Published: May 2019

Graphene quantum dots (GQDs) and graphene oxide quantum dots (GOQDs) can be selectively produced by wavelength-modulated pulsed laser ablation in liquid (PLAL) method, which can used in different applications such as optoelectronic and biomedical applications, respectively.
Directly imaging the structure–property correlation of perovskites in crystalline microwires
Authors: Zhang Xiao-Wei , Yang Zhen-Qian , Li Jing-Zhen , Deng Yu-Hao , Hou Yu-Min , Mao Yi-Fei , Lu Jing , Ma Ren-Min
Published: May 2019

MAPbI3 perovskite microwires show axially alternating perovskite and intermediate domain phases with distinctly different structural and photophysical properties.
A rare (3,12)-connected zirconium metal–organic framework with efficient iodine adsorption capacity and pH sensing
Authors: Guo Bingbing , Li Fugang , Wang Chiming , Zhang Liangliang , Sun Daofeng
Published: May 2019

We synthesized a rare (3,12)-connected zirconium metal–organic framework with a sky topology showing efficient iodine adsorption and pH sensing capacity.
Mapping the frontiers of quinone stability in aqueous media: implications for organic aqueous redox flow batteries
Authors: Tabor Daniel P. , Gómez-Bombarelli Rafael , Tong Liuchuan , Gordon Roy G. , Aziz Michael J. , Aspuru-Guzik Alán
Published: May 2019

The stability limits of quinones, molecules that show promise as redox-active electrolytes in aqueous flow batteries, are explored for a range of backbone and substituent combinations with high-throughput virtual screening.
Understanding the boosted sodium storage behavior of a nanoporous bismuth-nickel anode using operando X-ray diffraction and density functional theory calculations
Authors: Gao Hui , Song Lin , Niu Jiazheng , Zhang Chi , Kou Tianyi , Sun Yue , Qin Jingyu , Peng Zhangquan , Zhang Zhonghua
Published: May 2019

A novel channel-enhanced strategy upon atomic substitution via a dealloying process for the improved Na storage of alloying-type anodes for SIBs.
A dual-aptamer-based biosensor for specific detection of breast cancer biomarker HER2 via flower-like nanozymes and DNA nanostructures
Authors: Ou Dan , Sun Duanping , Lin Xiangan , Liang Zhixian , Zhong Yongsheng , Chen Zuanguang
Published: May 2019

A dual-aptamer electrochemical biosensor based on flower-like nanozymes and DNA nanostructures was fabricated for detection of breast cancer biomarker HER2.
Correction: Nutrient element-based bioceramic coatings on titanium alloy stimulating osteogenesis by inducing beneficial osteoimmmunomodulation
Authors: Chen Zetao , Yi Deliang , Zheng Xuebin , Chang Jiang , Wu Chengtie , Xiao Yin
Published: May 2019

Correction for ‘Nutrient element-based bioceramic coatings on titanium alloy stimulating osteogenesis by inducing beneficial osteoimmmunomodulation’ by Zetao Chen et al., J. Mater. Chem. B, 2014, 2, 6030–6043.
Superior energy storage performance and fatigue resistance in ferroelectric BCZT thin films grown in an oxygen-rich atmosphere
Authors: Reddy Seelam Rangaswamy , Prasad Velidandla Venkata Bhanu , Bysakh Sandip , Shanker Vishnu , Hebalkar Neha , Roy Subir Kumar
Published: May 2019

Processing in an oxygen rich atmosphere induced superior energy properties in lead free ferroelectric BCZT thin films.
Management of thermally activated delayed fluorescence using a secondary electron accepting unit in thermally activated delayed fluorescent emitters
Authors: Lee Ha Lim , Lee Kyung Hyung , Lee Jun Yeob , Hong Wan Pyo
Published: May 2019

A molecular design approach adopting secondary electron accepting units in addition to a main electron acceptor was investigated as a strategy to manage the thermally activated delayed fluorescent (TADF) performance of the emitters.
Janus NLO dendrimers with different peripheral functional groups: convenient synthesis and enhanced NLO performance with the aid of the Ar–ArFself-assembly
Authors: Liu Guangchao , Liao Qiuyan , Deng Haiyu , Zhao Wenjing , Chen Pengyu , Tang Runli , Li Qianqian , Li Zhen
Published: May 2019

Janus NLO dendrimers with different peripheral functional groups were constructed by combining the “Janus” topology and the Ar–ArFself-assembly effect.
fault detection for switched systems with all subsystems unstable
Authors: Su Qingyu , Fan Zhongxin , Li Jian
Published: May 2019

This study focuses on the fault detection for a switched system with all subsystems unstable. Firstly, to eliminate the instability brought by unstable modes, the average dwell time method is introduced to generate the time‐driven switching signal. Under the effect of the signal, the exponential stability is guaranteed. Afterwards, the authors utilise the Luenberger observer as the fault detector. Considering the unobservable conditions (A, C), this study gives the new solution to the observer design. Taking the disturbance robustness and fault sensitivity into account, they borrow the mixed performance index from the existing researches. Sufficient conditions are supplied to ensure the system is exponentially stable with mixed performance using linear matrix inequalities. Finally, examples are provided to prove the validity and effectiveness of the proposed switching method and designed fault detector.
Roles of IEC in supporting effective Smart City standards
Authors: Mulquin Michael J.
Published: May 2019

The International Electrotechnical Commission is using its systems approach, honed in the development of international smart grid standards, to identify the requirements of cities and smart city solution providers for tried and tested solutions to common challenges and is working with the wider international standards development community to develop the coherent and interoperable packages of standards needed. This study discusses such developments and provides insights into the current state‐of‐the‐art.
FPGA implementation of an arbitrary resample rate, FOH, pulse width modulator
Authors: Broadmeadow Mark A. H. , Burstinghaus Edward J. , Walker Geoffrey R. , Ledwich Gerard F.
Published: May 2019

This study presents a field‐programmable gate array implementation of an advanced pulse‐width modulator which combines a first‐order hold (FOH) with phase accumulator carrier pulse‐width modulation (PACPWM) for significantly reduced phase delay, and bandwidth extension in multi‐level applications. The FOH block supports arbitrary resampling rates and operates in a single clock cycle for simple integration into multi‐rate or asynchronous systems. The proposed modulator is validated experimentally, with performance matching that predicted for both FOH and a zero‐order hold (ZOH). For PWM with 8 kHz carrier frequency and 50.4 kHz resampling frequency, a 15 degree phase delay advantage is demonstrated for FOH compared with ZOH across the 5–10 kHz modulation band.
Evaluation of DC‐link voltage ripple in five‐phase PWM voltage source inverters
Authors: Vujacic M. , Hammami M. , Dordevic O. , Grandi G.
Published: May 2019

This paper presents the analysis of the DC‐link voltage switching ripple in five‐phase PWM voltage source inverters with balanced load. The analysis is particularly important for the design and selection of a DC‐link capacitor making it possible to meet desired electrical performance of the inverter system. Simple and practical equation for designing the DC‐link capacitor is proposed relating the value of capacitance to the maximum value (peak‐to‐peak) of the DC‐link voltage ripple. The amplitude of the DC‐link voltage switching ripple is analytically derived as a function of modulation index, and the amplitude of the output current and phase angle. In order to show peak‐to‐peak voltage ripple distribution, different diagrams are introduced. Reference is made to continuous symmetric centred PWM modulation (i.e., space vector modulation SVM). In order to verify proposed developments, simulations have been carried out by Matlab/Simulink considering full range of modulation index and output phase angle.
Experimental and numerical analysis of incremental magnetic pulse welding of dissimilar sheet metals
Authors: Psyk Verena , Linnemann Maik , Scheffler Christian
Published: May 2019

Magnetic pulse welding is a solid-state welding process using pulsed magnetic fields resulting from a sudden discharge of a capacitor battery through a tool coil in order to cause a high-speed collision of two metallic components, thus producing an impact-welded joint. The joint is formed at room temperature. Consequently, temperature-induced problems are avoided and this technology enables the use of material combinations, which are usually considered to be non-weldable. The extension of the typically linear weld seam can reach several hundred millimetres in length, but only a few millimetres in width. Incremental or sequential magnetic pulse welding is a promising alternative to obtain larger connected areas. Here, the inductor is moved relative to the joining partners after the weld sequence and then another welding process is initiated. Thus, the welded area is extended by arranging multiple adjacent weld seams. This article demonstrates the feasibility of incremental magnetic pulse welding. Furthermore, the influence of important process parameters on the component quality is investigated and evaluated. The suitability of different mechanical testing methods for determining the strength of the individual weld seams is discussed. The results of numerical simulation are consulted in order to obtain deep understanding of the observed effects.
The Fresnel triprism and the circular polarization of light
Authors: Arteaga Oriol , Garcia-Caurel Enric , Ossikovski Razvigor
Published: May 2019

In 1822 Augustin Fresnel discovered the circular polarization of light with an experiment in which a plane polarized beam was resolved into its left- and right- circularly polarized components after refraction at slightly different angles at the interface between two different species of quartz that formed a composite prism, called the Fresnel triprism. Fresnel’s landmark experiment, once popular, remains today a very little known method for producing circularly polarized light.
Traumatisme maternel et désir de la fille dans le contexte de la culture chinoise
Authors: Li Na
Published: May 2019

Dans le contexte de la culture chinoise, cet article analyse, en s’appuyant sur la théorie lacanienne des trois registres, des cas cliniques afin d’identifier l’origine du traumatisme générationnel du côté de la mère et reconnaître son inévitabilité. Sous l’influence du traumatisme générationnel, la naissance d’une fille cause à sa mère un effet de castration secondaire. Dans une analyse de la culture chinoise, cet article montre que le traumatisme intergénérationnel de la mère et le désir de la fille révèlent l’espoir d’un retour au monde du corps et de l’esprit de la mère, mais aussi d’un retour au désir de la mère. Ils sont probablement la cause de l’abondance et de la diversité des symptômes somatiques chez les patients chinois. Ainsi, la castration secondaire condamne à l’indigence : une femme ne pourra jamais atteindre son destin de désir maternel.
Influence de la préparation physique sur les relations interpersonnelles : Une étude exploratoire
Authors: Relave Antoine , Campo Mickaël , Nicolas Michel
Published: May 2019

La préparation physique (PP) peut s’envisager sous différentes formes : dissociée, associée ou intégrée. Chacune d’entre elles présentant des avantages et des inconvénients d’un point de vue physiologique, le but de cette étude a été d’explorer le lien entre forme de PP et relations interpersonnelles à travers le vécu émotionnel des participants. Dix joueurs de rugby âgés entre 16 et 18 ans (M = 16,90, SD = 0,74), ont participé à cette étude qualitative exploratoire. À partir d’entretiens d’auto-confrontation faisant suite à une séance de PP mobilisant les trois formes, des tendances ont pu être dégagées en termes de ressenti émotionnel et de relations interpersonnelles. Ces tendances sembleraient montrer que la PP, à travers ses trois formes, provoquerait des ressentis émotionnels distincts, pouvant favoriser le partage émotionnel et ainsi améliorer les relations interpersonnelles chez des joueurs en formation.
Indikation zur Therapie der Trikuspidalklappe bei rechts- und/oder linksventrikulären Erkrankungen
Authors: Ruf Tobias , Schmidt Kai , Kreidel Felix , Münzel Thomas , von Bardeleben Ralph
Published: May 2019

Während die Trikuspidalklappenstenose eine Rarität darstellt, ist die Trikuspidalklappeninsuffizienz (TI) eine häufige Herzklappenerkrankung und trägt signifikant zur Morbidität und Mortalität der Bevölkerung bei. Die sekundäre TI ist die häufigste Form und steht in einem komplexen Zusammenspiel zwischen Links- und Rechtsherzfunktion, den pulmonalen Druckverhältnissen, dem Volumenstatus und der Größe des rechten Vorhofs. Der Goldstandard zur Diagnose der TI ist die Echokardiografie. Der Rechtsherzkatheteruntersuchung kommt wegen der verlässlichen Bestimmung der prä- und postkapillären pulmonalen Druckverhältnisse und ihrer ätiologischen Klärung eine wichtige Bedeutung zu. Die aktuellen Leitlinien liefern Empfehlungen für die chirurgische Therapie der Trikuspidalklappe auf dem Boden von Expertenmeinungen. Insbesondere die Operation der sekundären TI wird nur dann empfohlen, wenn gleichzeitig eine linkskardiale Operationsindikation besteht. Die Ergebnisse der chirurgischen Therapie der isolierten TI in Bezug auf intrahospitale Mortalität und Dauerhaftigkeit des Operationsergebnisses sind problematisch. Interventionelle Ansätze auf Transkatheterbasis – aktuell noch in der frühen klinischen Erprobung und mit der ersten CE-Zulassung 2018 des Edwards Cardiobandes zeigen erste vielversprechende Ergebnisse und eröffnen die Perspektive, Morbidität und Mortalität dieses komplex erkrankten Patientenkollektivs positiv zu beeinflussen.
Kortison-Injektionen an der Wirbelsäule (periartikulär, nervennah, epidural)
Authors: Jablawi Fidaa , Schöller Karsten
Published: May 2019

Wirbelsäulennahe Kortison-Injektionen gehören zu den heutzutage am weitesten verbreiteten medizinischen Prozeduren überhaupt. Durch die epidurale, intra- und periartikuläre Applikation der Steroide sollen inflammatorisch getriggerte, therapieresistente Schmerzen von nozizeptivem und neuropathischem Charakter beeinflusst werden.

Auch wenn das Risiko der Infiltrationen insgesamt gering ist, wurden Fälle mit schweren neurologischen Komplikationen wie z. B. nach zervikalen, epiduralen transforaminalen Injektionen beschrieben. Insgesamt scheint das Risikoprofil nicht kristalliner Steroide wie dem Dexamethason bei allenfalls geringgradig niedrigerer Effektivität im Vergleich mit den häufig gebrauchten kristallinen Steroiden günstiger zu sein.

Die wissenschaftliche Evidenz zur Effektivität der verschiedenen wirbelsäulennahen Steroidinfiltrationen steht in einem starken Kontrast zu deren häufigen Anwendungen. Sämtliche Techniken der Steroid-Applikation haben einen limitierten Nutzen bei lokalen Schmerzen, die beste Evidenz für eine kurzfristige Schmerzlinderung besteht für die epidurale Steroidinfiltration bei radikulären Schmerzen.
Robot-Assisted McKeown Procedure via a Cervical Mediastinoscopy Avoiding an Abdominal and Thoracic Incision
Authors: Egberts Jan-Hendrik , Schlemminger Mark , Hauser Charlotte , Becker Thomas
Published: May 2019

Total esophagectomy for esophageal cancer is associated with high morbidity. The avoidance of a thoracic access could especially reduce the occurrence of pulmonary complications. Therefore, the combination of a high transhiatal dissection of the esophagus and a neck access with mediastinal dissection of the esophagus appears to be a possibility to reduce the pulmonary risks. However, the access to the posterior mediastinum is very limited with the conventional minimal invasive instruments. These limitations can be overcome by the use of a surgical robot.

In this article, we present a novel operation technique for a complete robot-assisted (da Vinci Xi) McKeown procedure avoiding a thoracic approach and abdominal incision by using a rendezvous technique with an abdominal and cervical docking of the robot system.
Clinical Trials in PBC Going Forward
Authors: Corpechot Christophe
Published: May 2019

New treatments for primary biliary cholangitis (PBC) are progressively emerging, including first and second generations of farnesoid X receptor and peroxisome proliferator-activated receptors agonists. Even though ursodeoxycholic acid monotherapy remains the standard of care treatment for PBC, these additional therapeutic options, already or soon to be available, lead us to revise our priorities and strategies with respect to future clinical trials. The present article is a personal view of where we currently stand in this field and where and how we should be going to achieve new progress.
Combined vEEG and Cerebral Oximetry Results to Determine the Severity of Hypoxic–Ischemic Encephalopathy
Authors: Pacella Marisa , Ghosh Suman , Middlebrook Erik , Bennett Jeffrey , Bliznyuk Nikolay , Huene Melissa , Copenhaver Nicole , Sura Livia , Weiss Michael D.
Published: May 2019

The objectives of the study were to evaluate the prognostic utility of bedside monitoring tools for hypoxic–ischemic encephalopathy (HIE) outcome and develop a prognostic predictive model. This retrospective study reviewed neonatal HIE treated with hypothermia between 2013 and 2016. Continuous video electroencephalography (vEEG) recordings scored for background electrocerebral activity, seizure, and sleep–wake cycles, and rSO2 data were stratified by magnetic resonance imaging (MRI) severity. The vEEG and rSO2 were combined in a predictive model. The analysis included 38 patients. The rSO2 was significantly higher in the severe group. vEEG showed early and persistent maximal suppression in the severe group. The predictive correlation of the rSO2 improves when combined with the vEEG.
Genetic Techniques Used in the Diagnosis of Inherited Platelet Disorders
Authors: Mumford Andrew D. , Westbury Sarah K.
Published: May 2019

Recent advances in genetic analysis are bringing huge benefits to patients with rare genetic disorders, including those with inherited disorders of platelet number and function. Modern clinical hematological practice now has a range of genetic techniques available to enable the precision diagnosis of inherited platelet disorders (IPDs). There are some features of this disparate group of inherited disorders that present specific challenges to establishing an accurate genetic diagnosis. This review aims to introduce the techniques that are relevant for the genetic diagnosis of IPDs and will discuss the key considerations necessary for their application to the clinic.
Endocarditis: An Ever Increasing Problem in Cardiac Surgery
Authors: Ostovar Roya , Schroeter Filip , Kuehnel Ralf-Uwe , Erb Michael , Filip Tomas , Claus Thomas , Albes Johannes M.
Published: May 2019

Background Endocarditis remains one of the most threatening diagnoses in cardiac surgery and is still increasing. Particularly, device-related as well as prosthetic endocarditis appears to be on the rise. Early mortality and periprocedural complications are high jeopardizing the success of surgical efforts. We looked at the development of the numbers and the distribution of endocarditis in an all-comer analysis.

Methods From 2003 to 2017, 752 patients with endocarditis were transferred to our cardiosurgical institution (mean age 65 ± 13 years; mean logistic EuroSCORE 28.01%; males 74.33%). A total of 89.49% of them were surgically treated; 30.01% redo cases thereof; and 9.17% had been operated previously for acute endocarditis.

Results While the total number of cardiosurgical procedures remained relatively stable throughout the years, 20 patients were admitted in 2003 and 79 in 2017 yielding more than fourfold increase (p < 0.001). Early mortality of all patients was 25.1%. Septic emboli occurred in 23.7% and 43.8% cerebral emboli thereof. A significant increase of aortic, mitral, and tricuspid valves involvement was observed (p < 0.001). An increase of device-related endocarditis was also noted (p < 0.001).

Conclusion Endocarditis remains a serious problem with high early mortality and morbidity. The vast increase of electrophysiological device implantations has resulted in an increase of tricuspid valve involvement. Liberalization of endocarditis prophylaxis, that is, more restrictive use of antibiotics in 2007 may have at least partially contributed to an increase of the individual risk to suffer from acute endocarditis. A renaissance of a stricter endocarditis–prophylaxis may thus be considered.
Diffusing an Innovation: Clinician Perceptions of Continuous Predictive Analytics Monitoring in Intensive Care
Authors: Kitzmiller Rebecca , Vaughan Ashley , Skeeles-Worley Angela , Keim-Malpass Jessica , Yap Tracey , Lindberg Curt , Kennerly Susan , Mitchell Claire , Tai Robert , Sullivan Brynne , Anderson Ruth , Moorman Joseph
Published: May 2019

Background The purpose of this article is to describe neonatal intensive care unit clinician perceptions of a continuous predictive analytics technology and how those perceptions influenced clinician adoption. Adopting and integrating new technology into care is notoriously slow and difficult; realizing expected gains remain a challenge.

Methods Semistructured interviews from a cross-section of neonatal physicians (n = 14) and nurses (n = 8) from a single U.S. medical center were collected 18 months following the conclusion of the predictive monitoring technology randomized control trial. Following qualitative descriptive analysis, innovation attributes from Diffusion of Innovation Theory-guided thematic development.

Results Results suggest that the combination of physical location as well as lack of integration into work flow or methods of using data in care decisionmaking may have delayed clinicians from routinely paying attention to the data. Once data were routinely collected, documented, and reported during patient rounds and patient handoffs, clinicians came to view data as another vital sign. Through clinicians' observation of senior physicians and nurses, and ongoing dialogue about data trends and patient status, clinicians learned how to integrate these data in care decision making (e.g., differential diagnosis) and came to value the technology as beneficial to care delivery.

Discussion The use of newly created predictive technologies that provide early warning of illness may require implementation strategies that acknowledge the risk–benefit of treatment clinicians must balance and take advantage of existing clinician training methods.