bluuebunny/crossref_metadata_2025 huggingface dataset:
THE BACKGROUND AND DEVELOPMENT OF QUALITY OF LIFE AND FAMILY QUALITY OF LIFE: APPLYING RESEARCH, POLICY, AND PRACTICE TO INDIVIDUAL AND FAMILY LIVING
Authors: Brown Roy I. , Schippers Alice
Published: December 2018

This article introduces the concepts of quality of life and family quality of life and shows how they have developed in the field of intellectual and developmental disabilities in terms of concepts and principles. The article underscores the relevance of many of the principles and practices to a wide range of disabilities and challenges in the broad field of human development. Finally, the article provides an introduction to the other articles in this special issue, and considers their relationship to the broader areas of research, practice, and policy.
THE GOLDEN TRIANGLE OF HAPPINESS: ESSENTIAL RESOURCES FOR A HAPPY FAMILY
Authors: Cummins Robert A.
Published: December 2018

It is normal for people to feel positive about the quality of their lives, despite the presence of challenges. Of special interest here are the challenges of caring for a child or a disabled family member. How do the adults living within such families maintain a positive self-view? Answering this question requires an understanding of subjective well-being as it applies to each individual family member and of the management system that strives to keep each person feeling positive. This paper describes various psychological components of this homeostatic management system, together with a consideration of the most useful resources to support homeostasis. Key resources have been identified by using the Personal Wellbeing Index, a seven-item scale measuring subjective well-being (mood happiness). Over many studies, researchers have found considerable agreement that three kinds of resources — “the Golden Triangle” — are consistently more relevant to subjective well-being than the others. These are feelings of satisfaction with income, relationships, and life purpose. The implications for interventions that offer support to families in need are discussed.
FAMILY QUALITY OF LIFE AND NURTURING THE SIBLING RELATIONSHIP
Authors: Kyrkou Nicole
Published: December 2018

Research that gauges family quality of life in families that include a child with a disability has often focused on the relationship between parents and the child, but in doing so they underestimate the importance of the sibling relationship: siblings are in each other’s lives generally for a much longer period of time than parents are. The sibling relationship is not intrinsically positive or negative, but it is a dynamic and critical bond; from it children can learn to understand and advocate for themselves and each other in the context of the disability. The sibling relationship is a lifelong one. Nurturing it in the early stages of development will not only support family quality of life, but will set the foundation for healthy adult sibling relationships that can create positive outcomes for all members of the family. The important aspects of nurturing the sibling relationship are considered from the viewpoint of both sibling and parent. The assumptions that inform sibling relationships are discussed, and suggestions for nurturing them are provided.
Protocole EMDR pour le traitement d’incidents critiques récents : un essai contrôlé randomisé dans un contexte de catastrophe technologique
Authors: Siegel Irene R.
Published: December 2018

Cette recherche visait à évaluer l’efficacité du protocole de désensibilisation et de retraitement par les mouvements oculaires pour les incidents critiques récents (EMDR-PRECI) pour réduire les symptômes de stress post-traumatique liés à l’explosion d’une usine d’explosifs, au nord de Mexico, qui avait coûté la vie à sept salariés. On a administré l’EMDR-PRECI pendant deux journées consécutives à 25 rescapés présentant des symptômes de stress post-traumatique liés à l’incident critique. La moyenne des résultats des participants, au SPRINT (entretien bref d’évaluation de l’ESPT — Short PTSD Rating Interview), était de 22, bien supérieure à la valeur seuil clinique de 14. Ils furent assignés de façon aléatoire à deux conditions de traitement (l’une en traitement immédiat et l’autre en liste d’attente/traitement différé) et la thérapie fut mise en place dans les quinze jours qui suivirent l’explosion. Les résultats montrèrent un effet principal significatif pour le facteur de condition, F(1, 80) = 67.04, p < .000. Les résultats SPRINT étaient significativement différents au cours du temps, démontrant l’efficacité de la thérapie EMDR sur la durée, F(3, 80) = 150.69, p < .001. On trouva également un effet d’interaction important entre condition et temps, F(2, 80) = 55.45, p < .001. La mesure de temps 2 mit en évidence des différences significatives entre les deux conditions de traitement (post-traitement immédiat vs. post-traitement différé), t(11) = -10.08, p < .000. Les effets du traitement s’étaient maintenus lors du suivi, 90 jours plus tard. Les résultats montrèrent également une amélioration subjective importante chez les participants. Cet essai contrôlé randomisé fournit une preuve de l’efficacité de l’EMDR-PRECI à réduire les symptômes de stress post-traumatique consécutifs à une catastrophe technologique.
Fiche technique de l’impact de l’amendement du substrat en poudre de coquille d’œuf de poule sur la reproduction de Archachatina marginata (Swainson, 1821)
Authors: Baptiste Aman Jean , Didier Memel Jean , Daniel Kouassi Kouadio , Atcho Otchoumou
Published: December 2018

This study consists in looking for an improvement of Archachatina margina reproductions performances by amendment of the breeding substrates. As a result, five types of substrate were prepared by soil amendment at different rates (0%, 10%, 20%, 30% et 40%) with chicken egg shell powder. On these substrates, snails were raised from spat stage until they were laid. Reproductive parameters such as: age of first laying, the number of annual laying per animal, the number of eggs per laying on the different substrates were recorded. Overall, snail laying performances improved with increasing rate of substrate amendment. However, beyond a rate of 20%, the weight of eggs laid began to decline. The chicken egg shell powder is suitable for the amendment of the breeding substrate of snails Archachatina marginata in view of an improvement in their reproductive performance. The rate of amendment recommended to this effect is 20%.
Evaluation du comportement trophique de Aedes aegypti dans la ville de cotonou au sud du Bénin
Authors: Anges Yadouleton , Gado Dramane , K.M. Ahadji-Dabla , Ramziyath Agbanrin , Carine Tchibozo , Achaz Agolinou , Roland Tossou , Lamine Baba-Moussa
Published: December 2018

In order to evaluate the trophic behavior of Aedes aegypti in the city of Cotonou, southern Benin, a cross-sectional study was conducted in urban and periurban neighborhoods from April 2016 to August 2017 to collect Ae. Aegypti populations. To achieve this goal, day and night collections, twice a month for one year were done where Ae. Aegypti populations were caught by Human Landing Catch and BG-Sentinel traps. 3,892 Aedes caught by different methods showed that Ae. Aegypti and Ae. circumluteolus are more abundant in urban than peri-urban areas (p<0.05). The aggressive density of Ae. aegypti populations was significantly higher in urban areas (157.43 bites per man per hour) than in peri-urban areas (32.43 bites per man per hour) (p<0.05). Also, out of 250 females blood-fed Ae. Aegypti tested by ELISA (Enzyme Linked Immunosorbent Assay) technique for blood meal identification, 86.80% took their blood meal on humans compared to 4.4% which took their blood meal on sheeps. These findings showed that the city of Cotonou in southern Benin, offered good condition for the development of Ae. aegypti population. The anthropology and endophagy behavior of this mosquito observed through the results of this study is a very favorable clue to vector control strategies based on the use of long-lasting impregnated mosquito nets and insecticide residual sprays adopted in Benin.
OS REFUGIADOS VENEZUELANOS E SUA RECEPÇÃO NA NOVA LEI DE MIGRAÇÃO
Authors: Jacomini Alessandro , Fernandes Gabriela Simoni , Maciel Letícia Maerki
Published: December 2018

O presente trabalho estuda a entrada de refugiados no Brasil, dando enfoque aos refugiados venezuelanos, às leis que os ampararam e à nova Lei de Migração que entrou em vigor em novembro de 2017, revogando o Estatuto do Estrangeiro, pois se tratava de uma legislação formulada na Ditadura Militar e, por tanto, carregava os ideais dessa época deixando a desejar alguns princípios dos Direitos Humanos, como a dignidade da pessoa humana. Para isso, utilizou-se o entendimento de renomados autores como Florisbal Del’Olmo, Rosita Milesi, Ribeiro Leão, entre outros, e o método escolhido foi a análise documental e análise bibliográfica, onde uma série de informações de artigos e livros referentes ao assunto foi encontrada, além, claro, da própria legislação. Também recorremos ao auxílio de informações eletrônicas, como o site da ACNUR que tem um trabalho efetivo com os refugiados. Através deste artigo pode-se compreender o que a Nova Lei de Migração trouxe de ganhos e prejuízos aos refugiados. Para isso, observar-se-á também a evolução desse conceito de refugiado através do tempo e, especificamente, no Brasil.
Long-term survival in a patient with metastatic HER2+ breast cancer undergoing lapatinib-based therapy for 6 years
Authors: Turano Salvatore , Conforti Serafino
Published: December 2018

We report the case of a patient with HER2-positive breast cancer under adjuvant therapy (chemotherapy and trastuzumab) who developed a recurrence with bone (cervical spine) and lung involvement. After treatment with lapatinib and capecitabine, the patient remained stable with considerable improvement of her physical condition. After 6 years she is still in maintenance therapy with lapatinib. This case is among a number of long term surviving and long term responding patients, within an atypical subset of patients with HER2-positive metastatic breast cancer, in the presence of encephalic lesions (Oncology).
HER2-positive breast cancer with brain metastasis: long-lasting response after lapatinib treatment
Authors: D'Alonzo Alessia , Bighin Claudia
Published: December 2018

We report the case of a 50-year-old patient diagnosed with breast cancer with lymph node, lymph node, pulmonary and hepatic secondaryisms. After receiving a first line chemotherapy containing taxanes, pertuzumab and trastuzumab, the patient developed asymptomatic brain metastases. She is therefore treated with panencephalic radiotherapy and second line treatment with trastuzumab emtansine. Further to systemic and cerebral disease progression, the patient is treated with capecitabine and lapatinib. This treatment lasted approximately 6 months with sustained efficacy on secondary lesions and an excellent tolerance profile (Oncology)
A careful evaluation of the therapeutic choice is necessary in every phase of diabetes progression
Authors: Malighetti Maria Elena
Published: December 2018

National and international diabetes guidelines recommend achieving a target value of glycated hemoglobin value that is dependent upon various factors including patient age, disease duration, co-morbidities, life expectancy and socio-economic conditions. The drug of choice is usually metformin, which can be associated with different classes of oral and injective drugs including insulin, in order to optimize the glycemic balance with the lowest possible risk of hypoglycemic episodes. The clinical case we report shows how a correct therapeutic choice, specifically with linagliptin, can reach a good glycemic control even in elderly subjects, suffering from diabetes mellitus for many years, starting from a severe metabolic imbalance after a multi-year therapy with sulphonylureas (Diabetology).
Atrial fibrillation in patient with high thrombotic risk: which therapy?
Authors: Dell'Era Gabriele
Published: December 2018

We report the case of an elderly patient suffering for about 20 years of hypertensive cardiac hypertrophy, carotid and peripheral vasculopathy. The patient, initially treated with oral anticoagulant therapy (dicumarol) due to relapsing atrial fibrillation, is an example of long-term use of dabigatran, dictated by safety concern in a patient at high risk of bleeding: as demonstrated by the RE-LY trial, dabigatran 110 mg / day has a preventive effect on cerebral events similar warfarin but with a lower incidence of bleeding. In this case, at high risk both thrombotic and hemorrhagic, the choice of dabigatran was successful in the long term (Cardiology).
Pulmonary embolism in a patient in dual antiplatelet therapy after placement of a drug-eluting stent
Authors: Vedovati Maria Cristina
Published: December 2018

Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism (PE), is the third most frequent cardiovascular disease and is characterized by high mortality and disability rate. According to the 2014 European Society of Cardiology guidelines for the treatment of PE, anticoagulant therapy is recommended in patients with acute PE for a period of at least 3 months in order to prevent both early mortality and recurrence of VTE. To date, there are no studies conducted on the triple antithrombotic therapy in patients with VTE subjected to percutaneous coronary interventions. We report the case of an elderly patient in dual antiplatelet therapy following coronary revascularization and stenting. The patient, following an episode of PE with cardiac arrest after 12 days of hospitalization, was successfully treated with anticoagulant therapy with dabigatran in association with the dual antiplatelet therapy already in place (Cardiology).
COMPARATIVE STUDY OF SOCIO-ECONOMIC VEGETABLE FARMING BETWEEN EAST JAVA AND BALI
Authors: Mariyono Joko , Daroini Putu B , Dewi Hanik A , Latifah Evy
Published: December 2018

This paper analyses the household and farm characteristics of vegetable farming in four regions of East Java and Bali provinces. Household and farm characteristics are important in research and development project, particularly when the project intervenes with improved technological packaged. Household and farm characteristic are analyzed using descriptive approach by comparing and contrasting each characteristic across regions. Data were compiled from a field survey of 360 farmers during 2013-2014. The results show that every region has distinct characteristics. Vegetable farming was characterized by small-scale and fragmented farm. The land was closely situated around the home. Level of education was low. Being a farmer was the main occupation. Suitable policies related to these conditions should pay attention to the small-scale farming issues.
Die Bedeutung der reellen Zahlen
Authors: Kuch  , Kuch Sven
Published: December 2018

Bislang als unrelevant eingeschätzt, - die qualitative Bedeutung der wichtigsten acht reellen Zahlen. Deren Verständnis erweist sich als wichtiger Schlüssel, weil reelle Zahlen(qualitäten) anders zu interpretieren sind als imaginäre Zahlen.
Gesetzmässigkeiten in den Ausdehnungsgebietzen Q-4 und Q-3
Authors: Kuch  , Kuch Sven
Published: December 2018

Hier werden die geltenden, bzw. nicht mehr geltenden mathematischen Gesetzmässigkeiten und deren Wirkung auf die Entstehung der Formen beschrieben.
Adaptation Strategies of Sitiarjo Villagers in Water Supply and Sanitation to Face The Health Impacts of Floods
Authors: Suliono Suliono
Published: December 2018

One of the impacts of climate change is the increasing frequency of flood disaster in Sitiarjo Village, Malang Regency. In recent years, the impact of floods in the form of emerging and rising infectious diseases has been suppressed.. Adaptation strategies implemented in disaster management are thought to be influential factors in the success of disaster risk reduction.This study aims to examine in depth the pattern of adaptation applied in the cycle of disaster management in Sitiarjo Village. This study aims to examine in depth the adaptation strategy adopted in the cycle of disaster management in Sitiarjo Village. The research method is qualitative with case study approach. The subjects of research are the elements directly involved in disaster management consisting of Puskesmas Health Workforce, Village Government Officer, Disaster Volunteer, and Community.The results show that the community adaptation strategy has been running well in the context of disaster preparedness which includes: modification of house design, supply of drinking water and clean water, closet closure and air pit in latrines. While in the context of emergency response, each sector has taken the necessary tasks such as medical action and quality recovery of dug wells.The duties of disaster volunteers such as SIBAT and SBH are very important in empowering the community to create a resilient community.There is still a gap in access to information and tools for the recovery of dug wells in some areas.The conclusion that can be drawn is that most people have adopted a good adaptation strategy in the field of water supply and sanitation to face the health impact of flood disaster. To improve the quality of disaster management still needed additional materials and supporting equipment for Puskesmas and community, and capacity building for disaster volunteers.
High Level of Phenol Urine and Health Complaints in The Benzene-Exposed Workers in Small Industry of Slippers Wedoro Sidoarjo
Authors: Setiowati Dinda
Published: December 2018

Benzene with its volatile nature results in people who live close to benzene are prone to be exposed. The main metabolic result of benzene is urine phenol. The aim of this study is to analyze high level of phenol in the urine and health complaints towards the benzene-exposed workers in a small industy of slippers Wedoro Sidoarjo. The method of this study is observational analytic research with cross sectional design and the study id analyzed using Mann–Whitney U Test in order to carry out the differences of phenol level in the urine. The subject of the study consists of 20 respondents drawn from the population in accordance with predetermined criteria. Interviews are held in order to obtain the information of the studied variables. The free variables of the study are regarding the level of benzene in the air, age of the workers, working hours, days of working, length of working, nutrition status, and health complaints. The bound variable of the study is the phenol level in the urine. The result of the study shows that the level of benzene in the air inside the production room exceeds the threshold value of 2.97 ppm, there are differences in the level of urinary phenol between the group with and without benzene exposure (p=0,000), a number of health complaints stated by the benzene-exposed workers are nervous system complains (90%) and hematological complaints (80%). In conclusion, there is high level of phenol in urine as well as health complaints of the benzene-exposed workers in the small industry of Wedoro Sidoarjo slippers. Therefore, the workers should use personal protective equipment in the form of mask and the industry should make a policy in terms of work rotation for a month.
Kajian Kebijakan Pengampunan Pajak dengan Pendekatan Eksperimental
Authors: Kurniawan Benny Robby , Juanda Bambang , Bakhtiar Toni
Published: December 2018

This research was conducted because the uncertainty in the tax amnesty policy. The purpose of this research is to analyze the effect of taxpayer’s expectation of future tax amnesty, tariff period system, tax penalty and audit towards tax compliance in tax amnesty policy, using experimental economics. The result shows that, a tax amnesty followed by strict audit and tax penalties will rise tax compliance. Tax amnesty policy is best applied once in a lifetime, because the expectation of the taxpayers towards future tax amnesty will result in lowering the compliance. Taxpayers prefer the lowest rate on tariff period. ======================== Penelitian ini dilakukan karena ketidakpastian keberhasilan dari kebijakan pengampunan pajak. Tujuan penelitian ini adalah untuk menganalisis pengaruh dari faktor ekspektasi masyarakat akan adanya pengampunan pajak di kemudian hari, sistem tarif pengampunan, denda, dan pemeriksaan pajak terhadap kepatuhan pada kebijakan pengampunan pajak dengan menggunakan metode ekonomi ekperimental. Hasil penelitian menunjukkan bahwa pengampunan pajak diikuti dengan penerapan denda dan pemeriksaan yang ketat akan meningkatkan kepatuhan pajak. Kebijakan pengampunan pajak sebaiknya diterapkan satu kali saja karena jika masyarakat berekspektasi akan adanya kebijakan serupa di kemudian hari, wajib pajak akan menunggu kebijakan tersebut dan tetap tidak patuh. Wajib pajak umumnya menyukai tarif pengampunan terendah.
Routine Diagnostic Tests for Periprosthetic Joint Infection Demonstrate a High False-Negative Rate and Are Influenced by the Infecting Organism
Authors: Kheir Michael M. , Tan Timothy L. , Shohat Noam , Foltz Carol , Parvizi Javad
Published: December 2018

Background:

Current guidelines recommend serum erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) as the first-line testing for evaluation of suspected periprosthetic joint infection, in addition to synovial white blood-cell (WBC) count and polymorphonuclear percentage. However, the sensitivity and other diagnostic measures of these tests using a standardized definition of periprosthetic joint infection and the influence of organisms on these inflammatory markers remain inadequately investigated.

Methods:

A retrospective review of an institutional database of 549 periprosthetic joint infection cases and 653 aseptic total joint arthroplasty revisions was performed. Periprosthetic joint infection was defined using major criteria from the International Consensus Meeting (ICM) on Periprosthetic Joint Infection. The mean inflammatory marker levels were compared among organisms with Student t tests and the proportions of elevated laboratory levels were compared among organisms with chi-square analyses. Receiver operating characteristic curve analyses were performed to calculate new cutoffs, sensitivities, and specificities for each organism and overall for serum CRP and ESR and synovial WBC and polymorphonuclear percentage.

Results:

The sensitivity of these markers for diagnosing chronic periprosthetic joint infection was 0.85 for ESR, 0.88 for CRP, 0.83 for WBC count, and 0.78 for polymorphonuclear percentage. For ESR, antibiotic-resistant organisms had higher mean values (84.3 mm/hr) than culture-negative cases (57.4 mm/hr), coagulase-negative Staphylococcus (68.3 mm/hr), and Streptococcus species (66.1 mm/hr); Staphylococcus aureus (81.0 mm/hr) was higher than culture-negative cases (57.4 mm/hr). For CRP, culture-negative cases had lower mean values (41.0 mg/L) than gram-negative organisms (87.4 mg/L), antibiotic-resistant organisms (86.0 mg/L), S. aureus (112.2 mg/L), and Streptococcus species (114.6 mg/L); S. aureus (112.2 mg/L) was higher than coagulase-negative Staphylococcus (66.0 mg/L). For WBC count, culture-negative cases had lower mean values (27,984.5 cells/mL) than S. aureus (116,250.0 cells/mL) and Streptococcus species (77,933.7 cells/mL). For polymorphonuclear percentage, there were no significant differences in mean values among all organisms.

Conclusions:

It appears that serological markers, namely ESR and CRP, have a higher false-negative rate than previously reported. Synovial markers similarly exhibit high false-negative rates. Furthermore, the sensitivity of these tests appears to be related to organism type. Surgeons should be aware of the high rate of false-negatives associated with low-virulence organisms and culture-negative cases.

Level of Evidence:

Diagnostic Level I. See Instructions for Authors for a complete description of levels of evidence.
Posteromedial Elbow Dislocations without Relevant Osseous Lesions
Authors: Cho Chul-Hyun , Kim Beom-Soo , Rhyou In Hyeok , Park Sam-Guk , Choi Sung , Yoon Jong Pil , Choi Chang-Hyuk , Dan Jinmyoung
Published: December 2018

Background:

Although simple posterolateral or posterior elbow dislocations are relatively common and usually stable after closed reduction, simple posteromedial dislocations are extremely rare and poorly characterized. We investigated the clinical characteristics, soft-tissue injury patterns, treatments, and outcomes of a series of posteromedial elbow dislocations without relevant osseous lesions.

Methods:

We retrospectively reviewed 20 cases of simple posteromedial elbow dislocations without relevant osseous lesions that were treated at 7 fellowship training hospitals during a 10-year period. Soft-tissue injury patterns in 15 cases were investigated with use of magnetic resonance imaging. Clinical outcomes were evaluated after an average of 56.1 months (range, 24 to 93 months) with use of the Mayo Elbow Performance Score (MEPS) and the Quick-DASH (an abbreviated version of the Disabilities of the Arm, Shoulder and Hand [DASH]) score. Complications were also evaluated.

Results:

On magnetic resonance imaging, significant tears of the lateral collateral ligament complex and common extensor group were observed in all cases. Seventeen cases (85%) required surgical treatment for acute instability. Fourteen cases underwent only lateral complex repair and 3 underwent repair of both the medial and lateral complexes. At the time of the latest follow-up, the mean MEPS and Quick-DASH scores were 85.8 ± 15.0 and 10.5 ± 16.3, respectively. Seventeen patients (85%) had a satisfactory clinical outcome. Complications following treatment included 4 patients with heterotopic ossification; 2 of these patients also experienced posttraumatic elbow stiffness, which was treated with arthrolysis at 8 and 18 months after the initial operation.

Conclusions:

Posteromedial elbow dislocations without relevant osseous lesions are associated with a more severe soft-tissue injury, especially to the lateral complex, resulting in a high rate of surgical treatment. With careful post-reduction evaluation, either operative or nonoperative treatment provided satisfactory clinical outcomes.

Level of Evidence:

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Time-Driven Activity-Based Costing to Identify Patients Incurring High Inpatient Cost for Total Shoulder Arthroplasty
Authors: Menendez Mariano E. , Lawler Sarah M. , Shaker Jonathan , Bassoff Nicole W. , Warner Jon J.P. , Jawa Andrew
Published: December 2018

Background:

As payment models shift toward a focus on value, an accurate understanding of surgical costs and preoperative correlates of high-cost patients is important for effective implementation of cost-saving strategies. This study used time-driven activity-based costing (TDABC) to explore inpatient cost of total shoulder arthroplasty (TSA) and to identify preoperative characteristics of high-cost patients.

Methods:

Using TDABC, we calculated the cost of inpatient care for 415 patients undergoing elective primary TSA between 2016 and 2017. Patients in the top decile of cost were defined as high-cost patients. Multivariable logistic regression modeling was employed to determine preoperative characteristics (e.g., demographics, comorbidities, American Society of Anesthesiologists [ASA] score, and American Shoulder and Elbow Surgeons [ASES] score) associated with high-cost patients.

Results:

Implant purchase price was the main driver (57%) of total inpatient costs, followed by personnel cost from patient check-in through the time in the operating room (20%). There was a 1.3-fold variation in total cost between patients in the 90th percentile for cost and those in the 10th percentile; the widest cost variation was in personnel cost from the post-anesthesia care unit through discharge (2.5-fold) and in medication cost (2.4-fold). High-cost patients were more likely to be women and chronic opioid users and to have diabetes, depression, an ASA score of ≥3, a higher body mass index (BMI), and a lower preoperative ASES score than non-high-cost patients. After multivariable adjustment, the 3 predictors of high-cost patients were female sex, an ASA score of ≥3, and a lower ASES score. Total inpatient cost correlated strongly with the length of the hospital stay but did not correlate with operative time.

Conclusions:

Our study provides actionable data to contain costs in the perioperative TSA setting. From the hospital’s perspective, efforts to reduce implant purchase prices may translate into rapid substantial cost savings. At the patient level, multidisciplinary initiatives aimed at reducing length of stay and controlling medication expenses for patients at risk for high cost (e.g., infirm women with poor preoperative shoulder function) may prove effective in narrowing the existing patient-to-patient variation in costs.

Level of Evidence:

Economic and Decision Analysis Level IV. See Instructions for Authors for a complete description of levels of evidence.
Functional Outcomes Following Treatment for Clubfoot
Authors: Jeans Kelly A. , Karol Lori A. , Erdman Ashley L. , Stevens Wilshaw R.
Published: December 2018

Background:

The purpose of this study was to assess function, at the age of 10 years, of children initially treated nonoperatively for clubfoot with either the Ponseti or French physiotherapy program and to compare outcomes in feet that had undergone only nonoperative treatment with those that required subsequent surgery.

Methods:

Gait analysis, isokinetic ankle strength, parent-reported outcomes, and daily step activity data were collected when patients who had been treated for idiopathic clubfoot reached the age of 10 years. Patients who had undergone only nonoperative treatment were compared with those who subsequently underwent extra-articular surgery or intra-articular surgery (posterior release or posteromedial release). The clubfoot groups were compared with age-matched controls.

Results:

Of 263 treated clubfeet in 175 patients, 148 had only been treated nonoperatively, 29 underwent extra-articular surgery, and 86 underwent intra-articular surgery (posterior release in 42 and posteromedial release in 44). Significant abnormalities were found in ankle kinetics and isokinetic ankle strength in the feet treated with intra-articular surgery compared with the nonoperatively treated feet (p < 0.017). Compared with controls (n = 40 feet), all groups showed reduced ankle plantar flexion during gait, resulting in a deficit of 9% to 14% for dynamic range of motion, 13% to 20% for ankle moment, and 13% to 23% for power (p < 0.013). Within the intra-articular group, feet that underwent posteromedial release had decreased plantar flexion strength (15%; p = 0.008), dorsiflexion strength (6%; p = 0.048), and parent-reported global function scores (p = 0.032) compared with the posterior release group. The patients with clubfoot took 10% fewer steps (p = 0.015) and had 11% less total ambulatory time (p = 0.001) than the controls.

Conclusions:

Examination of patients when they had reached the age of 10 years showed better ankle power and isokinetic strength for clubfeet treated without surgery compared with those that underwent intra-articular surgery for residual deformity or recurrence. Compared with controls, both nonoperatively and surgically treated clubfeet had significant limitations in ankle plantar flexion resulting in decreased range of motion, moment, and power. Gastrocnemius-soleus complex strength was decreased after both nonoperative and surgical treatment of clubfeet. Although activity was diminished in the clubfoot population, no differences in function were perceived by the patients’ parents.

Level of Evidence:

Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Outcomes of the Ponseti Method for Untreated Clubfeet in Nepalese Patients Seen Between the Ages of One and Five Years and Followed for at Least 10 Years
Authors: Banskota Bibek , Yadav Prakash , Rajbhandari Tarun , Shrestha O.P. , Talwar Divya , Banskota Ashok , Spiegel David A.
Published: December 2018

Background:

To our knowledge, there are no reports of the Ponseti method initiated after walking age and with >10 years of follow-up. Our goal was to report the clinical findings and patient-reported outcomes for children with a previously untreated idiopathic clubfoot who were seen when they were between 1 and 5 years old, were treated with the Ponseti method, and had a minimum follow-up of 10 years.

Methods:

A retrospective review of medical records was supplemented by a follow-up evaluation of physical findings (alignment and range of motion) and patient-reported outcomes using the Oxford Ankle Foot Questionnaire for Children (OxAFQ-C). The initial treatment was graded as successful if a plantigrade foot was achieved without the need for an extensive soft-tissue release and/or osseous procedure.

Results:

We located 145 (91%) of 159 patients (220 clubfeet). The average age at treatment was 3 years (range, 1 to 5 years), and the average duration of follow-up was 11 years (range, 10 to 12 years). The initial scores according to the systems of Pirani et al. and Diméglio et al. averaged 5 and 17, respectively, and an average of 8 casts were required. Surgical treatment, most commonly a percutaneous Achilles tendon release (197 feet; 90%), was required in 96% of the feet. A plantigrade foot was achieved in 95% of the feet. Complete relapse was rare (3%), although residual deformities were common. Patient-reported outcomes were favorable.

Conclusions:

A plantigrade foot was achieved in 95% of the feet initially and was maintained in most of the patients, although residual deformities were common. Patient-reported outcomes were satisfactory, and longer-term follow-up with age-appropriate outcome measures will be required to evaluate function in adulthood.

Level of Evidence:

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Chronic Lumbar Spondylolysis in an Adolescent Hockey Player
Authors: Sivanich Ashley , Shultz John , Raja Avais
Published: December 2018

Lumbar spondylolysis is an underreported condition in adolescents who play the sport of ice hockey. Managing spondylolysis in a growing adolescent proves to be challenging in regard to sport restrictions and return to play. Advanced imaging, including magnetic resonance imaging (MRI) or single-photon emission computed tomography (SPECT), should be acquired in order to reach a faster definitive diagnosis. Some cases may lead to a chronic form of spondylolysis that requires patience from the provider, the patient, and the patient’s family.
Método de apuração de custos: estudo de caso em uma fundação de apoio de Minas Gerais
Authors: Cintra Leandro Pinheiro , Vidigal Pedro Guatimosim , Braga Renato da Costa
Published: December 2018

Este artigo apresenta um método de apuração dos custos para uma Fundação de Apoio, a partir do estudo de seu caso. Foi realizado mapeamento de suas áreas, cujas técnicas de coleta de dados utilizadas foram: consulta a arquivos e documentos internos, entrevistas semiestruturadas e observações não participantes. Como resultados, foram identificados os procedimentos, os recursos e as atividades desenvolvidas. A análise, por triangulação, permitiu que fossem definidas as métricas de rateio para cada centro de custo, o que permitiu as comparações com os construtos teóricos disponíveis e a descrição sobre como o método de custeio por absorção se adéqua às necessidades de precificação e tomada de decisões. Foi possível identificar que a fundação apresenta como produto final as atividades realizadas pelas gerências de Pessoal, Compras, Importação e Prestação de Contas. Propõem-se futuros estudos sobre o potencial de aplicação dométodo de custeio adotado a outras fundações de apoio.
The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: statistical analysis plan for a randomised controlled trial
Authors: Salman Rustam Al-Shahi , Murray Gordon D. , Dennis Martin S. , Newby David E. , Sandercock Peter A.G. , Sprigg Nikola , Sudlow Cathie L.M. , Werring David J. , White Philip M. , Whiteley William N.
Published: December 2018

Background: For adults surviving stroke due to spontaneous (non-traumatic) intracerebral haemorrhage (ICH) who had taken an antithrombotic (i.e. anticoagulant or antiplatelet) drug for the prevention of vaso-occlusive disease before the ICH, it is unclear whether starting antiplatelet drugs modifies the risks of recurrent ICH, haemorrhagic events, vaso-occlusive events, or a composite of all serious vascular events compared to avoiding antiplatelet drugs.
Methods/design: The REstart or STop Antithrombotics Randomised Trial (RESTART) is an investigator-led, parallel group, open, assessor-blind, randomised trial comparing starting versus avoiding antiplatelet drugs for adults surviving antithrombotic-associated ICH. Recruitment began on 22 May 2013 and ended on 31 May 2018. Follow-up ends on 30 November 2018. This update to the protocol describes the statistical analysis plan (version 1.6, finalised on 18 September 2018). Data lock is expected to occur on 11 January 2019, after which the un-blinded trial statistician will conduct the final analyses according to this statistical analysis plan.
Discussion: Final results of RESTART will be analysed and disseminated in 2019.
Trial registration: ISRCTN registry 71907627. Prospectively registered on 25 April 2013.
Funding/sponsor: The trial is funded by a British Heart Foundation special project grant (SP/12/2/29422) and a travel fellowship (FS/13/72/30531). The trial sponsor is the Academic and Clinical Central Office for Research and Development (ACCORD), which is a partnership between the University of Edinburgh and NHS Lothian Health Board.
The Effect of Phacoemulsification plus Goniosynechialysis in Acute and Chronic Angle Closure Patients with Extensive Goniosynechiae
Authors: Tian Tian , Li Mei , Pan Yingzi , Cai Yu , Fang Yuan
Published: December 2018

Background Patients with primary angle closure/glaucoma (PAC/PACG) with extensive peripheral anterior synechiae (PAS), and coexisting cataract, increasingly have been treated with phacoemulsification combined with goniosynechialysis (Phaco-GSL). Since the mechanisms of acute and chronic PAC/PACG may differ, the treatment effect of this procedure also may differ. The purpose of this study was to establish whether there was a difference in the therapeutic effect of Phaco-GSL on these patients, which might provide clinical evidence for giving more accurate treatment for them.
Methods This study was a retrospective cohort study. Twenty-seven patients, 13 with acute PAC/PACG and 14 with chronic PAC/PACG, were treated surgically by Phaco-GSL. The intraocular pressure (IOP), surgical success rate, the need of medication, the extent of PAS, the time and the rate of recurrence of PAS (re-PAS) and other indicators were observed post-operatively for at least three months.
Results After surgery, IOP decreased (preoperative vs postoperative: 29.77±11.55 mmHg vs 14.92±1.66 mmHg in the acute group and 26.00±11.2 mmHg vs 14.93±2.7 mmHg in the chronic group), the extent of PAS reduced (preoperative vs. postoperative: 314.23±49.07° vs 116.54±73.78° in the acute group and 285.00±53.28° vs 156.43±56.35° in the chronic group), the topical and systemic anti-glaucoma drug requirements decreased, in both groups and in the acute group, respectively. Compared with the acute group, the success rate (acute vs chronic: 100% vs 64.3%) was lower in the chronic group, while the incidence of re-PAS (acute vs chronic: 30% vs 83.3%) were higher in the chronic group. All differences mentioned above were statistically significant (p < 0.05). In addition, there were five patients in total who showed re-PAS of more than 90° (4 in chronic group and 1 in acute group) and all these re-PASs formed within 1 week postoperatively.
Conclusion Although Phaco-GSL is effective in both groups, there may be differences in the effect between the two groups. Chronic patients are more susceptible to re-PAS. Thus, these patients should be observed closely and treated appropriately in the early post-surgical time period.
Sclerotherapy for dilated veins of atypical localization
Authors: Bogachev V. Yu. , Grusha Ya. O. , Lobanov V. N.
Published: December 2018

The article describes the method of aesthetic correction of dilated non-varicose superficial veins localized on the face, décolleté and upper extremities. It is concluded that the various sclerotherapy options are highly efficient and safe in these clinical situations.
Detection of the efficiency of microwave–oxidation process for meat industry wastewater by dielectric measurement
Authors: Jákói Zoltán , Hodúr Cecilia , László Zsuzsanna , Beszédes Sándor
Published: December 2018

Our experimental work focused on the applicability of a quite novel process for wastewater treatment, i.e. a microwave (MW) irradiation-enhanced Fenton-like method. The aim of our research was to detect and evaluate the efficiency of this oxidation process, during the treatment of meat industry wastewater containing a high concentration of organic material. The efficiency was defined by the measurement of the change in COD (chemical oxygen demand, with an initial COD value of 1,568 mg L−1), and with the determination of dielectric parameters during the process. It can be summarized that MW irradiation could assist in a Fenton-like oxidation process to achieve higher organic matter removal. Furthermore, our experimental results and statistical analysis show that there can be found a correlation between the effects of applied MW energy and the dosage of H2O2/FeSO4. If the intensity of MW irradiation and the amount of FeSO4 were set higher, the decrease of COD and the increase of tanδ (the dielectric loss tangent) were definitely more significant. With the application of 60 kJ MWE and a 0.14 mgFe2+/mgCOD dosage, the COD removal efficiency was more than 40%, and the increment of tanδ was nearly threefold. Considering the effects of MW-specific process parameters, it can be concluded that the power intensity of MW–oxidation treatment has a significant effect on COD decrease, if the irradiated MW energy was set at lower (30–45 kJ) levels.
Paul Singer: Memórias de uma experiência aprendente
Authors: Schiochet Valmor
Published: December 2018

Paul Singer é um dos maiores economistas que tivemos mas em verdade foi um grande educador a semelhança de Paulo Freire. Para ele tudo se traduzia em oportunidade de aprendizagem. Chegou a definir a economia solidária como um ato pedagógico em si . Assim podemos dizer também que a convivência com o professor é uma experiência aprendente.
Understanding Membrane Protein Drug Targets in Computational Perspective
Authors: Gong Jianting , Chen Yongbing , Pu Feng , Sun Pingping , He Fei , Zhang Li , Li Yanwen , Ma Zhiqiang , Wang Han
Published: December 2018

Membrane proteins play crucial physiological roles in vivo and are the major category of drug targets for pharmaceuticals. The research on membrane protein is a significant part in the drug discovery. The biological process is a cycled network, and the membrane protein is a vital hub in the network since most drugs achieve the therapeutic effect via interacting with the membrane protein. In this review, typical membrane protein targets are described, including GPCRs, transporters and ion channels. Also, we conclude network servers and databases that are referring to the drug, drug-target information and their relevant data. Furthermore, we chiefly introduce the development and practice of modern medicines, particularly demonstrating a series of state-of-the-art computational models for the prediction of drug-target interaction containing network-based approach and machine-learningbased approach as well as showing current achievements. Finally, we discuss the prospective orientation of drug repurposing and drug discovery as well as propose some improved framework in bioactivity data, created or improved predicted approaches, alternative understanding approaches of drugs bioactivity and their biological processes.
New Chalcone Derivative: Synthesis, Characterization, Computational Studies and Antioxidant Activity
Authors: Ustabaş Reşat , Süleymanoğlu Nevin , Özdemir Namık , Kahriman Nuran , Bektaş Ersan , Ünver Yasemin
Published: December 2018

A new chalcone derivative, called as 1-(4-(benzylideneamino)phenyl)-3-(furan-2-yl)prop-2-
en-1-one (I), was synthezised and characterized by spectral methods (infrared (IR) and proton and carbon-
13 nuclear magnetic resonance (1H- and 13C-NMR) spectroscopy). A computational study was
performed by the density functional theory (DFT) method. Spectral data of compound I optimized by
using 6-311G(d,p) and 6-311++G(d,p) basis sets were obtained by 6-311++G(d,p) basis set. The E-Z
isomerism for newly synthesized chalcone derivative was investigated by considering four isomeric
form, E/E, E/Z, Z/E and Z/Z. The results show that, as assumed and thus named, the chalcone
derivative is in the E/E form. In addition, quantum chemical parameters were calculated by using DFT
method with 6-311++G(d,p) basis set. Antioxidant activity of compound I was determined by the ferric
reducing ability of plasma (FRAP) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay methods. Compound
I has low antioxidant activity.
Preparation of Biscarbonylmethylenetriphenylphosphorane Derivatives: A Mini-Review
Authors: Villamizar-Mogotocoro Andrés-Felipe , Urbina-González Juan-Manuel , Rincón-Valdivieso Ingrid
Published: December 2018

Biscarbonylmethylenetriphenylphosphoranes are versatile compounds derived from stabilized α-carbonylmethylenetriphenylphosphoranes, mainly prepared by transylidation or by analogue methodologies; other procedures include electrochemical oxidation, palladium-catalized insertions and displacements reactions with tellurol esters, as well as the use of Bestmann’s ylide with different reagents and reaction conditions. These biscarbonylmethylenetriphenylphosphoranes are usually converted into acetylenes by thermal treatments. Biscarbonylmethylenetriphenylphosphoranes and their oxidation products -vicinal tricarbonyl compounds- are of high importance due to their use as synthons of more complex molecules and their promising biological activity.
A Comparison of Antioxidant Effects of Some Selected Fruits with Butylated Hydroxytoluene on Egg Yolk
Authors: Mohajer Afsaneh , Sadighara Parisa , Mohajer Mehri , Farkhondeh Tahereh , Samarghandian Saeed
Published: December 2018

Background:

Antioxidants are commonly used in food products to prolong their shelf life.
Regarding the potential risks of synthetic antioxidants, people’s tendency toward natural antioxidants
is growing. The present study was designed to evaluate the antioxidant activities of some fruits versus
synthetic antioxidants such as Butylated Hydroxytoluene (BHT).

Methods:

In this study, the antioxidant activities of the alcoholic extract of some fruits including
grape, date, olive, fig and pomegranate versus BHT were evaluated by using the egg yolk. The oxidative
stability of samples was measured by thiobarbituric acid reactive substances (TBARS) assay.

Results:

Present findings showed that the levels of lipid oxidation in egg yolk exposed to olive and
pomegranate extracts were similar to the levels of lipid oxidation of egg yolk exposed to BHT.

Conclusion:

The study suggested that pomegranate extract may be used as a natural antioxidant instead
of chemical compounds.