bluuebunny/crossref_metadata_2025 huggingface dataset:
A Humanização do Cuidado na Hemodiálise
Authors: Rodrigues Aline  Scharr , Ravagnani Juliana Furlan , Barbosa Michelly Sarmento , Silva Felipe Bueno da , Brito Gabriella Vasconcelos de , Milagres Clarice Santana
Published: February 2022

As modificações nos padrões alimentares associados à redução de atividades físicas e as transformações demográficas apresentam relação direta com o aumento constante no índice de doenças crônicas, das quais a Doença Renal Crônica se destaca com importante incidência mundial. No Brasil, essa doença tem aumentado consideravelmente e estima-se que haja, por ano, 42.500 novos casos de portadores, com tendências para aumentar. Devido o aumento no número de pacientes em diálise e do contato frequente desses com profissionais de saúde, faz-se necessário a humanização desse processo, proporcionando o acolhimento do paciente e seus familiares, através de ações de promoção de saúde aliadas à construção coletiva em rede com equipes multiprofissionais. Objetivo: realizar uma revisão de literatura sobre a importância da humanização da enfermagem junto ao paciente em tratamento de hemodiálise, demonstrando a importância do acolhimento junto ao portador de doença renal. Métodos: revisão de literatura qualitativa, no qual foram analisados trabalhos em português e inglês, inseridos nas bases bibliográficas de dados internacionais PubMed e Science Direct, e nacionais BVS, Scielo e LILACS, com data de publicação dos artigos utilizados priorizados nos últimos dez últimos anos. Resultado: Pacientes hemodialíticos requerem humanização do atendimento de enfermagem para promover o bem-estar e o prolongamento da sobrevida com qualidade, além da contribuição para uma rotina agradável durante o tratamento. Conclusão: Um paciente portador de doença renal crônica em tratamento dialítico necessita de cuidado humanizado, proporcionado por profissionais através da relação interpessoal entre paciente e equipe, dando enfoque no respeito, atenção, paciência e cuidados especializados.
Violência Autoinfligida na Ótica da Equipe de um Programa de Transtornos Alimentares
Authors: Garbin Cléa Adas Saliba , Martins Ronald Jefferson , Belila Naiana de Melo , Saliba Tânia Adas , Garbin Artênio José Ísper
Published: February 2022

Introdução: A autopunição é aquela que ocorre quando uma pessoa pratica uma ação consciente de autodestruição (violência autoinfligida) e pode ser subdividida em comportamento suicida e em autoagressão. Objetivo: Verificou-se a violência autoinfligida na fala da equipe de saúde de pacientes com anorexia e bulimia nervosa do Programa de Transtornos Alimentares do Ambulatório de Saúde Mental de uma Instituição Pública de Ensino.  Materiais e métodos: Trata-se de uma pesquisa qualitativa realizada com médicos, psicólogos e cirurgião-dentista (n=9), pertencentes à equipe de saúde do programa. O grupo focal teve a participação de um moderador, observador e a equipe de saúde, empregando-se um roteiro com questões norteadoras. Os discursos foram gravados, transcritos e os conteúdos textuais processados no software IRAMUTEQ e analisados pela técnica da Nuvem de Palavras e Análise de Similitude. Resultados: Foram observadas 2.541 ocorrências de palavras, sendo 264 formas distintas. As palavras que obtiveram frequência relativa no corpus textual na primeira técnica foram: suicídio, não, muito, mutilar e burlar; e na segunda, o leque semântico central de palavras foi: muito, não, suicídio, mutilar e burlar. Conclusão: Conclui-se que a violência autoinfligida mostra-se muito presente entre mulheres com anorexia e bulimia nervosa.
Isolated Scaphoid Dislocation: A Case-Report
Authors: Serrano Sara Dadona Correia , Rezende Luis Guilherme Rosifini Alves
Published: February 2022

Isolated dislocations of the scaphoid are rare conditions in orthopedic practice and can be underdiagnosed. Early diagnosis and treatment are established by the current literature. Despite the few case reports described in the literature, treatment standards are still not well established, with different management techniques for this condition. We present the case report of a 31-year-old patient, presenting isolated dislocation of the left scaphoid. He underwent surgical management with closed reduction and percutaneous fixation with Kirschner wires. After removing the wires, the patient underwent physical therapy. His functional outcomes showed good recovery of function and range of motion of the wrist.
Perspectivas Psicossociais da “Síndrome do Ninho Vazio”: Uma Revisão Integrativa
Authors: Fonseca Artur Gimenez , Godas André Gustavo de Lima , Carvalho Giovanna Bruna de Almeida , Caldeira João Victor Camargo , Candido Mateus Teixeira , Moreira Adailson Silva
Published: February 2022

Introdução: A síndrome do ninho vazio (SNV) é acompanhada da solidão e depressão dos pais em resposta à partida de seus filhos de casa. Objetivo: Buscar, na literatura, informações existentes até o momento sobre a síndrome do ninho vazio, bem como fazer crítica reflexão sobre elas, relacionando-as ao atualizado conhecimento de fisiopatologia e psicologia para melhor compreender as manifestações desse estágio da vida familiar e, assim, constituir-se numa clara exposição a respeito do tema. Método: Através de uma Revisão Integrativa da Literatura (RIL), realizou-se uma pesquisa nas bases de dados Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) e Sistema Online de Busca e Análise de Literatura Médica (MedLine), no segundo semestre de 2021. Devido à carência de estudos, foi utilizado apenas um descritor: empty nest syndrome. Foram incluídos apenas artigos completos e publicados nos idiomas português, inglês e espanhol, dos anos de 2005 a 2021. Foram excluídos teses, dissertações, monografias, artigos em duplicata e artigos que não tratavam do objeto de estudo proposto. Resultado: Selecionou-se um total de quatorze artigos, divididos e analisados de acordo com três assuntos proposto para este estudo. Conclusão: Fica clara a relação causal entre sinais e sintomas psiquiátricos e a SNV, de maneira que o enfrentamento positivo ou negativo da fase pós-parental pode acarretar em agravos psicopatológicos, bem como ser positivo para a vida familiar. O estilo de vida e local em que a família assiste influem intensamente na maneira pela qual atravessa tal período. Fatores como gênero, condição socioeconômica e hierarquia de trabalho também são capazes de modificar a resposta da família e de seus indivíduos à SNV.
Repeat, fast, and high-resolution mapping of fine-scale trace element distribution in pyrite and marcasite by LA-Q-ICP-MS with the Aerosol Rapid Introduction System (ARIS)
Authors: Reynolds Merilie A. , Kamber Balz S. , McKenna Cora A. , Oelze Marcus , Gleeson Sarah A.
Published: February 2022

The minor and trace element composition of minerals provides critical insights into a variety of geological processes. Multi-element mapping by laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) is an important technique applied for this purpose and although the method is rapidly advancing, there remains a fundamental compromise between spatial resolution, detection limit, and experiment duration when using sequential mass analyzers. To address the limitation of limited analyte selection for high spatial resolution maps imposed by the sequential nature of typical quadrupole (Q)-ICP-MS, we tested the Aerosol Rapid Introduction System (ARIS) for repeat mapping of the same area. The ARIS is a high-speed transfer tubing system that reduces aerosol washout times, permitting resolution of individual pulses at 40–60 Hz. Here, the ARIS was tested not for pulse resolution but with novel operating conditions optimized to perform fast, high spatial resolution mapping of minor and trace element distribution in pyrite and marcasite. For this purpose, ablation was conducted with a 5 µm beam aperture, a repetition rate of 50 Hz, and a continuous stage scan speed of 40 µm s−1. For each LA-Q-ICP-MS map, data were acquired for six elements with an acquisition time of 20 ms per element. This deliberately reduced the individual pulse resolution of the ARIS but instead exploited the spatial resolution and sensitivity gains afforded by the high-laser repetition rate combined with efficient aerosol transfer. The new method successfully mapped trace elements at single to double-digit parts per million levels, and the maps reveal fine-scale zoning of trace elements with an effective x and y resolution of 5 µm, while white light interferometry showed that for each experiment, only ca. 1 µm of the sample was removed. Repeated mapping of the same area showed excellent correspondence not only between element concentrations in successive experiments but also in the shape, dimension, and location of regions of interest defined by concentration criteria. The very good repeatability of the elemental maps indicates that for studies requiring more analytes, successive mapping of additional elements is possible. By contrast with conventional very small spot (i.e., 5 µm) analysis, fast repetition rate and stage scan speed mapping avoids down-hole fractionation effects and minimizes accidental analysis of buried invisible inclusions. Compared to conventional LA-ICP-MS mapping, the method reduces the experiment time by 4–8 times.
Volume-preserving diffeomorphism as nonabelian higher-rank gauge symmetry
Authors: Du Yi-Hsien , Mehta Umang , Nguyen Dung , Son Dam Thanh
Published: February 2022

We propose nonabelian higher-rank gauge theories in 2+1D and 3+1D. The gauge group is constructed from the volume-preserving diffeomorphisms of space. We show that the intriguing physics of the lowest Landau level (LLL) limit can be interpreted as the consequences of the symmetry. We derive the renowned Girvin-MacDonald-Platzman (GMP) algebra as well as the topological Wen-Zee term within our formalism. Using the gauge symmetry in 2+1D, we derive the LLL effective action of vortex crystal in rotating Bose gas as well as Wigner crystal of electron in an applied magnetic field. We show that the nonlinear sigma models of ferromagnets in 2+1D and 3+1D exhibit the higher-rank gauge symmetries that we introduce in this paper. We interpret the fractonic behavior of the excitations on the lowest Landau level and of skyrmions in ferromagnets as the consequence of the higher-rank gauge symmetry.
Variational truncated Wigner approximation for weakly interacting Bose fields: Dynamics of coupled condensates
Authors: Mink Christopher , Pelster Axel , Benary Jens , Ott Herwig , Fleischhauer Michael
Published: February 2022

The truncated Wigner approximation is an established approach that describes the dynamics of weakly interacting Bose gases beyond the mean-field level.
Although it allows a quantum field to be expressed by a stochastic c-number field, the simulation of the time evolution is still very demanding for most applications.
Here, we develop a numerically inexpensive scheme by approximating the c-number field with a variational ansatz. The dynamics of the ansatz function is described by a tractable set of coupled ordinary stochastic differential equations for the respective variational parameters.
We investigate the non-equilibrium dynamics of a three-dimensional Bose gas in a one-dimensional optical lattice with a transverse isotropic harmonic confinement.
The accuracy and computational inexpensiveness of our method are demonstrated by comparing its predictions to experimental data.
Gas Chromatography-Mass Spectrometry Analysis and α-Glucosidase Inhibitory Activity of n-Hexane Extract of Bilajang Bulu (Merremia Vitifolia) Leaves
Authors: Tahya Candra Yulius , Karnelasatri Karnelasatri
Published: February 2022

One of the most effective treatments for diabetes mellitus is to inhibit α-glucosidase, which inhibits glucose absorption by the epithelium membrane of the small intestine. In South Sulawesi, Indonesia, Merremia vitifolia is used as a traditional medicine for the treatment of diabetes.  The aims of this study are to (1) assess the extract's ability to inhibit α - glucosidase and (2) identify volatile organic compounds in n-hexane of Merremia vitifolia extract. Extraction was conducted by maceration.  The inhibitory activity of quercetin towards α-glucosidase has the IC50 = 2.53 ± 0.16 µg/mL, and by n-Hexane extract of Merremia vitifolia leaves has the IC50 = 14.4 ± 1.52 µg/mL.  Then, n-Hexane extract of Merremia vitifolia leaves has strong α-glucosidase inhibitory activity. The compounds that have been identified based on Gas Chromatography-Mass Spectrometry (GC-MS) analysis with similarity index ≥ 89% which are caryophyllene (0.94%), (E)-β-famesene (4.72%), neophytadiene (9.78%), phytol (65.94%), 9,12,15-octadecatrienoic acid (6.71%), 1,5-cyclodecadiene (6.76%), squalene (4.48%), stigmasterol (4.08%), γ-sitosterol (10.20%), Serratol (23.12%), vitamin E (2.78%) and lup-20(29)-en-3-one (21.04%). Based on a literature study, the presence of phytol, neophytadiene, β-caryophyllene, stigmasterol, γ-sitosterol, and lup-20(29)-en-3-one have contributed to the strong α-glucosidase inhibitory activity of n-Hexane extract of Merremia vitifolia leaves.
Prediction of water source and water volume of underground reservoir in coal mine under multiple aquifers
Authors: Chi Mingbo , Cao Zhiguo , Wu Baoyang , Li Quansheng , Zhang Yong , Wu Yang , Wang Lujun , Yang Yi , Zhang Bao , Li Haixiang
Published: February 2022

The role of coal mine underground reservoirs (CMUR) in ‘guide storage and use’ greatly solves the problem of mine water waste. Replenishment and prediction of reservoir water sources provide an important support for the successful development of key technologies concerning CMUR. To study water replenishment for CMUR, the hydrogeological conditions of the Shendong mining area were investigated as an example. Based on the relationship between the development height of the ‘two belts’ of shallow coal seams and the relative occurrence of location of aquifers, the aquifers are generalized and classified according to occurrences location. Taking Bulianta coal mine as the research background, a discrete element fluid–solid coupling numerical simulation model is constructed to analyze the development characteristics of mining-induced fractures after coal seam mining, and the water replenishment channel of the CMUR is determined. On this basis, analysis is made on the change law of water pressure in the aquifer, aquifuge and coal seam roof under mining action. Taking hydraulic head pressure and water velocity as the judgment basis, prediction and evaluation are made on the water replenishment capacity of CMUR. The research results can provide references for coal mine safety production and mine water protection and utilization.
Microbial population changes and metabolic shift of candidatus accumulibacter under low temperature and limiting polyphosphate
Authors: Zheng Jianfeng , Wang Nan , Zhao Ledan , Li Yajing , Yu Jingjie , Wang Shaopo
Published: February 2022

This study explored the microbial population dynamics of Accumulibacter (Acc) at low temperature and metabolic shift to limiting polyphosphate (Poly-P) in enhanced biological phosphorus removal (EBPR) system. The Accumulibacter-enriched EBPR systems, fed with acetate (HAc) and propionate (HPr) at 10 ± 1 °C respectively, were operated for 60 days in two identical SBR reactors (SBR-1 and SBR-2). The phosphorus removal performance in two systems was stable at 10 ± 1 °C, while the microbial community structure changed. Compared with the population structure in seed sludge, Accumulibacter clades reduced in the HAc system, while Acc I increased significantly in the HPr system. Low temperature was beneficial to the formation of granular sludge in the EBPR system, and the sludge granulation in the HAc system was more homogeneous than that in the HPr system. Accumulibacter in the HPr system can get ATP through glycogen accumulating metabolism (GAM) under limiting Poly-P condition at 10 ± 1 °C, while that in the HAc system cannot. This work suggests that poly-P levels can affect the metabolic pathway of Accumulibacter in EBPR systems under low temperature.
Comparing statistical process control charts for fault detection in wastewater treatment
Authors: Marais H. L. , Zaccaria V. , Odlare M.
Published: February 2022

Fault detection is an important part of process supervision, especially in processes where there are strict requirements on the process outputs like in wastewater treatment. Statistical control charts such as Shewhart charts, cumulative sum (CUSUM) charts, and exponentially weighted moving average (EWMA) charts are common univariate fault detection methods. These methods have different strengths and weaknesses that are dependent on the characteristics of the fault. To account for this the methods in their base forms were tested with drift and bias sensor faults of different sizes to determine the overall performance of each method. Additionally, the faults were detected using two different sensors in the system to see how the presence of active process control influenced fault detectability. The EWMA method performed best for both fault types, specifically the drift faults, with a low false alarm rate and good detection time in comparison to the other methods. It was shown that decreasing the detection time can effectively reduce excess energy consumption caused by sensor faults. Additionally, it was shown that monitoring a manipulated variable has advantages over monitoring a controlled variable as set-point tracking hides faults on controlled variables; lower missed detection rates are observed using manipulated variables.
Tecnologías educativas para la inclusión
Authors: Bolaño García Matilde
Published: February 2022

Este libro producto de investigación invita a emplear las tecnologías en la educación y hace un llamado de atención a la comunidad educativa, específicamente a las entidades educativas, para que consideren y resignifiquen sus prácticas con el valor social que merecen. Para ello, es necesario colocarse en el lugar del otro, para no excluirlo, y educar desde las fortalezas del educando, no desde sus debilidades. En tal sentido, este trabajo presenta un modelo sui generis basado en un amplio marco teórico para un contexto escolar carente de inclusión social. Estos fundamentos hacen un aporte a partir de conceptos, características, posibilidades y discusiones para brindar recomendaciones de implementación de las tecnologías en la educación, en una era del conocimiento en la que se ha avanzado mucho en políticas inclusivas, pero muy poco en prácticas inclusivas. Por ende, esta obra pretende ser un puente entre la doctrina y la praxis para que en las instituciones pueda materializarse una práctica educativa integradora. Tecnologías educativas para la inclusión nos muestra que la integración de estas herramientas tecnológicas permitirá fortalecer los procesos educativos, más aún cuando se trata de estudiantes con capacidades diferenciales, y facilitará la enseñanza y el aprendizaje al hacerlos más motivadores y eficaces.
Co-creation of the energy transition agenda in the colombian caribbean
Authors: Santamaría Guerrero Rosa , Cardoso Díaz Andrea , Caselles Martínez Carolyn
Published: February 2022

Throughout its production and marketing chain, the coal industry generates a series of impacts and damages on ecosystems, communities, local territories, and the environment. Coal is the most polluting energy source and one of the leading causes of the rise in the planet’s temperature, and it is one of the greatest threats to life and the environment. In this way, since 2017, the Semillero de Investigación en Transición Energética de La Universidad del Magdalena (Energy Transition Research Seedbed of the University of Magdalena) has been jointly studying the impacts and realities of mineral coal exploitation in the Caribbean region in Colombia, in order to build, together with different actors in the region an energy transition agenda. This document brings together the results and reflections of the four Decarbonization and Transition Forums from the mining-energy model. Chapter 1 briefly introduces the global coal chain, its history, commercialization, and implications. Chapter 2 incorporates the concepts of climate justice and climate change into the coal production and consumption chain. Subsequently, Chapter 3 addresses the impacts of the extraction and transportation of coal in Colombia, and then, in Chapter 4, we provide approaches to a just transition within local territories. Finally, Chapter 5 explores the co-creation methodologies of the Transition Agenda and the development of co-creation spaces. By way of conclusion, regional autonomy, the guaranteeing of leaders’ rights, economic resources and investment, fair and sustainable alternatives, health and social reparation, participatory closure plans, and territorial perspective were, from the communities’ point of view, six crucial points which should be considered in the process of transition from coal-based economies to a productive reconversion within the departments of Cesar, La Guajira, and Magdalena.
An Innovative Approach in Nanotechnology-based Delivery System for the Effective
Management of Psoriasis
Authors: Parveen Shaheen , Ahmed Musheer , Baboota Sanjula , Ali Javed
Published: February 2022

Introduction:

Psoriasis is an incurable, non-contagious inflammatory autoimmune skin disease characterised
by abnormal skin redness and flaky patches on the body surface. It is caused by negative signals produced
by the immune system, leading to excessive growth and differentiation of keratinocytes and other inflammatory
reactions on the skin. The topical route is primarily preferred in treating skin disorders due to the
smaller size of the drug molecule, which allows them to cross the outer layer of the skin, i.e., stratum corneum,
and permeate into the deep layer, unlike transdermal and other routes. The conventional topical treatments used
in the past, such as coal tar and dithranol, lead to meager patient compliance due to decreased potency and imperfect
aesthetic. In contrast, systemic therapy such as methotrexate, cyclosporine, and acitretin produce related
side effects. At present, various novel carriers like liposomes, ethosomes, niosomes, nanostructured lipid carriers,
etc., have shown promising results in the treatment of psoriasis. Therefore, this review primarily concentrates
on the current advancements in novel carriers for various drugs to treat psoriasis topically.

Area covere:

The goal of this review is to provide a comprehensive overview of the pathophysiology, epidemiology,
types, causes, diagnosis, and topical treatment options for psoriasis, as well as the role of nanotechnology-
based delivery systems in psoriasis management.
Palladium-Catalysed Intermolecular Direct C–H Bond Arylation of Heteroarenes
with Reagents Alternative to Aryl Halides: Current State of the Art
Authors: Rossi Renzo , Ciofalo Maurizio
Published: February 2022

This unprecedented review with 322 references provides a critical up-to-date picture of the Pd-catalysed intermolecular direct C–H bond arylation of heteroarenes with arylating reagents alternative to aryl halides that include aryl sulfonates (aryl triflates, tosylates, mesylates, and imidazole-1-sulfonates), diaryliodonium salts, [(diacetoxy)iodo]arenes, arenediazonium salts, 1-aryltriazenes, arylhydrazines and N’-arylhydrazides, arenesulfonyl chlorides, sodium arenesulfinates, arenesulfinic acids, and arenesulfonohydrazides. Particular attention has been paid to summarise the preparation of the various arylating reagents and to highlight the practicality, versatility, and limitations of the various developed arylation protocols, also comparing their results with those achieved in analogous Pd-catalysed arylation reactions involving the use of aryl halides as electrophiles. Mechanistic proposals have also been briefly summarised and discussed. However,
data concerning Pd-catalysed direct C–H bond arylations involving the C–H bonds of aryl substituents of the examined heteroarene derivatives have not been taken into account.
Treating to Target Glycaemia in Type 2 Diabetes Pregnancy
Authors: Yamamoto Jennifer M. , Murphy Helen R.
Published: February 2022

There is an increasing awareness that in those who develop early-onset (18-39 years)
adult type 2 diabetes, an increase in insulin resistance, deterioration in beta-cell, and clustering of
cardiovascular risk factors are particularly pronounced. Pregnant women with type 2 diabetes have
additional risk factors for serious adverse pregnancy outcomes as well as added barriers regarding
healthcare access before, during, and after pregnancy. Compared to pregnant women with type 1
diabetes, those with type 2 diabetes are older, have higher body mass index (BMI), with more metabolic
comorbidities and concomitant medications, are more likely to belong to minority ethnic
groups, and live in the highest areas of socio-economic deprivation. Approximately, one in seven
pregnant women with type 2 diabetes (median age 34 years) are taking ACE-inhibitors, statins
(13%), and/or other potentially harmful diabetes therapies (7%). Fewer than one in four are taking
a high dose of folic acid before pregnancy, which may suggest that planning for pregnancy is not a
priority for women themselves, their healthcare professionals, or the healthcare system. Knowledge
of the epidemiology, pathophysiology, and unique management considerations of early-onset type
2 diabetes is essential to providing evidence-based care to pregnant women with type 2 diabetes.
This narrative review will discuss contemporary data regarding type 2 diabetes pregnancy outcomes
and the increasing recognition that different types of diabetes may require different treatment
strategies before, during, and after pregnancy.
Polyphenols as the Potential Disease-modifying Therapy in Cancer
Authors: Rogovskii Vladimir
Published: February 2022

Background:

Disease-modifying therapy in cancer can be defined as long-term treatment that has a beneficial
outcome on the course of cancer, affecting the underlying pathophysiology of cancer. The anticancer potential of
polyphenols is widely studied. However, there is a significant gap between experimental data obtained in vitro and in
vivo and the current role of polyphenols in cancer therapy.

Objective:

In this article, the reason for this inconsistency is discussed, which might be in the design of polyphenols
clinical trials. The approach of long-term polyphenol disease-modifying therapy in cancer is encouraged.

Conclusion:

The physiologic concentrations of polyphenols are not sufficient for reaching cytotoxic levels. Therefore,
the immune modulation and effects on cancer signal transduction pathways should be considered in the design of polyphenol
clinical trials. Such effects apparently can not cause the rapid regression of the disease. However, more likely,
they can modulate the course of the disease, leading to favorable changes in the patient's condition in case of long-term
treatment.
A 3-Year-Old Boy with an Xp21 Deletion Syndrome: A Case Report
Authors: Sadeghmousavi Shaghayegh , Shahkarami Sepideh , Rayzan Elham , Ahmed Souran , Gharalari Farzaneh Hosseini , Rohlfs Meino , Klein Christoph , Rezaei Nima
Published: February 2022

Background:

Chromosome Xp21 deletion syndrome is a rare X-linked recessive defect that occurs as a result of multiple gene deletions, including Glycerol kinase (GK) and its neighboring genes, dystrophin, which causes Duchenne muscular dystrophy (DMD), and NR0B1, which causes congenital adrenal hypoplasia (CAHhttps://www.omim.org/entry/300200). Patients usually present with glycerol kinase deficiency, congenital adrenal hypoplasia, Duchenne muscular dystrophy, hyperglycerolemia, and glyceroluria, associated with DMD and/or CAH, growth failure, myopathy, osteoporosis, mental retardation, and psychomotor retardation.

Case Presentation:

Herein, we report a 3-year- old boy from Iraq who had bloody diarrhea, food intolerance and abdominal cramp, adrenal insufficiency, recurrent fevers, tuberculosis (TB) infection, cervical abscess, oral thrush, cervical and mediastinal lymphadenopathies, developmental delay, and undescended testis. His parents are non-consanguine and had no family history of diseases. Next generation sequencing demonstrated a hemizygote deletion in chromosome X.

Conclusion:

Loss of a large part of the X-chromosome most likely can explain the clinical findings of this patient. Contiguous gene deletion syndrome in Xp21 should be considered after diagnosing adrenal insufficiency to treat metabolic complications efficiently.
Peningkatan Efisiensi Produksi Cokelat Kreatif Dengan Mesin Salut Cokelat Semi Otomatis
Authors:   Fakultas Teknologi Pertanian, Universitas Brawijaya, Maya Maharani Dewi , Asmaul Mustaniro Siti ,   Fakultas Teknologi Pertanian, Universitas Brawijaya
Published: February 2022

Shavir Chocollection adalah pelopor Usaha Kecil Menengah (UKM)Kreatif dalam bentuk salut Cokelat di Kota Batu dengan target wisatawan di Kota Wisata Batu, Jawa Timur. Kendala dalam proses produksi kreatif adalah tidak maksimalnya kapasitas produksi karena kurangnya penggunaan teknologi produksi, terutama pada pensalutan cokelat yang membutuhkan waktu 80% dari total produksi. Oleh karena itu, diperlukan alih teknologi yang akan meningkatkan produktivitas dan efisiensi dalam produksi Cokelat yaitu Mesin Salut Cokelat Semi Otomatis. Hasil dari pelaksanaan kegiatan PKM di UKM Cokelat adalah (1) Brainstorming dan FGD dengan UKM Cokelat kreatif tentang sistem produksi telah dilakukan,(2) Kegiatan penyuluhan, bimbingan teknis untuk UKM dengan konfigurasi dan implementasi SOP produksi cokelat dan inovasi dalam diversifikasi produk cokelat,(3) Fasilitasi peralatan teknologi produksi mesin untuk mitra,(4) Kegiatan konseling, pelatihan dan bimbingan teknis. (5) Monitoring dan evaluasi telah dilakukan untuk mengetahui perkembangan kegiatan.
Implementasi Mesin Penggoreng Mekanis Untuk Meningkatkan Produktivitas Dan Kualitas Kerupuk Amplang Di Ukm Yuan Kartika
Authors:   Jurusan Keteknikan Pertanian, Fakultas Teknologi Pertanian, Universitas Brawijaya, Damayanti Retno , Sandra Sandra ,   Jurusan Keteknikan Pertanian, Fakultas Teknologi Pertanian, Universitas Brawijaya, Susilo Bambang ,   Jurusan Keteknikan Pertanian, Fakultas Teknologi Pertanian, Universitas Brawijaya, Hendrawan Yusuf ,   Jurusan Keteknikan Pertanian, Fakultas Teknologi Pertanian, Universitas Brawijaya
Published: February 2022

The potential of mackerel fish reaches 5000 tons / year. Mackerel fish is not seasonal, which means it is available throughout the year. This is what makes Yuan Kartika UKM take advantage of the opportunity to process fish products into amplang crackers. Constraints experienced by SMEs so far are; 1) the amount of production that has not been optimal, because of inadequate production equipment, 2) the frying process is less efficient and requires labor skills; 3) marketing of products is still limited in the local area so that the income earned is not maximal. Based on the survey, SMEs need technology improvements for the frying process so that the process can be done semi-mechanically. Mechanical fryers have a capacity of 3-4 kg / process, twice as large as manual fryers which have a capacity of 2 kg of dough / process, so the production process is shorter and meets the SME production target of 30 kg / day. The frying process takes 15 minutes, faster than the manual frying process for 20 minutes. The level of comfort and safety in the frying process is also better, because the equipment is equipped with a protective / frame so that workers are not affected by heat due to the burner stove heating process. Production results are smooth and meet the production targets, and the quality of the amplang cracker products is the same both before and after the semi-mechanical fryer is applied.
Institutional Transformation of Ex-PNPM-MPd UPK as A Revolving Fund Institution in Candipuro District, Lumajang Regency
Authors:   University of August 17, 1945 Surabaya, Sulistyo Hadi , V. Rudy Handoko ,   University of August 17, 1945 Surabaya
Published: February 2022

The termination of PNPM Mandiri Perdesaan (PNPM-MPd) in 2015 required UPK of Candipuro District as a revolving fund institution to transform to obtain legal certainty. This study aimed to describe the transformation of revolving fund management in Candipuro UPK, Lumajang Regency. This study used a descriptive qualitative method to examine institutional transformation based on aspects of legality, institutional (organizational management), philosophy, finance, and business form
Appropriateness of the international accreditation frameworks of engineering education to the academic engineering programs in Saudi Arabia: A comparative study
Authors:   Department of Industrial Engineering, Northern Border University, Arar, Saudi Arabia, Aoudia Mouloud
Published: February 2022

This paper focuses on the globalization of engineering education which has become a major preoccupation of engineering departments everywhere. There is a lack of literature on the global recognition requirements of Saudi engineering education. Most of the papers published in the field of accreditation of Saudi engineering education focused on reporting the individual experiences of some engineering programs or on identifying the challenges facing these programs when seeking national or international accreditation. This paper examines and explores the main milestones in the path towards the global recognition of engineering education in Saudi Arabia. The only way such recognition can be achieved, however, is through membership in a handful of accreditation frameworks such as the Washington Accord (WA) and the European Accredited Engineer (EUR-ACE). The purpose of this paper is threefold: 1) to take stock of the accreditation status of engineering program in Saudi Arabia, 2) to compare the requirements, rules, and procedures of WA and EUR-ACE to determine which organization best serves the Saudi engineering programs’ desire to achieve international recognition, and finally 3) make some recommendations on actions the national accreditation agencies could take to become members of WA. Even though this paper focuses on engineering education in Saudi Arabia, it applies equally to other countries looking to meet the highest quality standards in engineering education and seeking to ensure the international mobility of their graduates.
Effectiveness of a Pharmacist-Led Web-Based Medication Adherence Tool With Patient-Centered Communication: Results of a Clustered Randomized Controlled Trial
Authors: van Lieshout Jan , Lacroix Joyca , van Halteren Aart , Teichert Martina
Published: February 2022

Background

Growing numbers of people use medication for chronic conditions; nonadherence is common, leading to poor disease control. A web-based tool to identify an increased risk for nonadherence with related potential individual barriers might facilitate tailored interventions and improve adherence.

Objective

This study aims to assess the effectiveness of a newly developed tool aimed at improving medication adherence.

Methods

We performed a cluster randomized controlled trial in patients initiating cardiovascular or oral blood glucose–lowering medication. Participants were recruited from community pharmacies. They completed an online questionnaire comprising assessments of their risk for medication nonadherence and subsequently of barriers to adherence. In pharmacies belonging to the intervention group, individual barriers displayed in a graphical profile on a tablet were discussed by pharmacists and patients with high nonadherence risk in face-to-face meetings and shared with their general practitioners and practice nurses. Tailored interventions were initiated by pharmacists. Barriers of control patients were not presented nor discussed and these patients received usual care. The primary outcome was the effectiveness of the intervention on medication adherence at 8 months’ follow-up between patients with an increased nonadherence risk from the intervention and control groups, calculated from dispensing data.

Results

Data from 492 participants in 15 community pharmacies were available for analyses (intervention 253, 7 pharmacies; control 239, 8 pharmacies). The intervention had no effect on medication adherence (B=–0.01; 95% CI –0.59 to 0.57; P=.96), nor in the post hoc per-protocol analysis (B=0.19; 95% CI –0.50 to 0.89; P=.58).

Conclusions

This study showed no effectiveness of a risk stratification and tailored intervention addressing personal barriers for medication adherence. Various potential explanations for lack of effectiveness were identified. These explanations relate, for instance, to high medication adherence in the control group, study power, and fidelity. Process evaluation should elicit possible improvements and inform the redesign of intervention and implementation.

Trial Registration

The Netherlands National Trial Register NTR5186; https://tinyurl.com/5d8w99hk
A Bayesian Network to Predict the Risk of Post Influenza Vaccination Guillain-Barré Syndrome: Development and Validation Study
Authors: Huang Yun , Luo Chongliang , Jiang Ying , Du Jingcheng , Tao Cui , Chen Yong , Hao Yuantao
Published: February 2022

Background

Identifying the key factors of Guillain-Barré syndrome (GBS) and predicting its occurrence are vital for improving the prognosis of patients with GBS. However, there are scarcely any publications on a forewarning model of GBS. A Bayesian network (BN) model, which is known to be an accurate, interpretable, and interaction-sensitive graph model in many similar domains, is worth trying in GBS risk prediction.

Objective

The aim of this study is to determine the most significant factors of GBS and further develop and validate a BN model for predicting GBS risk.

Methods

Large-scale influenza vaccine postmarketing surveillance data, including 79,165 US (obtained from the Vaccine Adverse Event Reporting System between 1990 and 2017) and 12,495 European (obtained from the EudraVigilance system between 2003 and 2016) adverse events (AEs) reports, were extracted for model development and validation. GBS, age, gender, and the top 50 prevalent AEs were included for initial BN construction using the R package bnlearn.

Results

Age, gender, and 10 AEs were identified as the most significant factors of GBS. The posttest probability of GBS suggested that male vaccinees aged 50-64 years and without erythema should be on the alert or be warned by clinicians about an increased risk of GBS, especially when they also experience symptoms of asthenia, hypesthesia, muscular weakness, or paresthesia. The established BN model achieved an area under the receiver operating characteristic curve of 0.866 (95% CI 0.865-0.867), sensitivity of 0.752 (95% CI 0.749-0.756), specificity of 0.882 (95% CI 0.879-0.885), and accuracy of 0.882 (95% CI 0.879-0.884) for predicting GBS risk during the internal validation and obtained values of 0.829, 0.673, 0.854, and 0.843 for area under the receiver operating characteristic curve, sensitivity, specificity, and accuracy, respectively, during the external validation.

Conclusions

The findings of this study illustrated that a BN model can effectively identify the most significant factors of GBS, improve understanding of the complex interactions among different postvaccination symptoms through its graphical representation, and accurately predict the risk of GBS. The established BN model could further assist clinical decision-making by providing an estimated risk of GBS for a specific vaccinee or be developed into an open-access platform for vaccinees’ self-monitoring.
Trends in Remote Health Care Consumption in Sweden: Comparison Before and During the First Wave of the COVID-19 Pandemic (Preprint)
Authors: Milos Nymberg Veronica , Ellegård Lina Maria , Kjellsson Gustav , Wolff Moa , Borgström Bolmsjö Beata , Wallman Thorne , Calling Susanna
Published: February 2022

BACKGROUND

Remote assessment of respiratory tract infections (RTIs) has been a controversial topic during the fast development of private telemedicine providers in Swedish primary health care. The possibility to unburden the traditional care has been put against a questionable quality of care as well as risks of increased utilization and costs. The COVID-19 pandemic has contributed to a changed management of patient care to decrease viral spread, with an expected shift in contact types from in-person to remote ones.

OBJECTIVE

The main aim of this study was to compare health care consumption and type of contacts (in-person or remote) for RTIs before and during the COVID-19 pandemic. The second aim was to study whether the number of follow-up contacts after an index contact for RTIs changed during the study period, and whether the number of follow-up contacts differed if the index contact was in-person or remote. A third aim was to study whether the pattern of follow-up contacts differed depending on whether the index contact was with a traditional or a private telemedicine provider.

METHODS

The study design was an observational retrospective analysis with a description of all index contacts and follow-up contacts with physicians in primary care and emergency rooms in a Swedish region (Skåne) for RTIs including patients of all ages and comparison for the same periods in 2018, 2019, and 2020.

RESULTS

Compared with 2018 and 2019, there were fewer index contacts for RTIs per 1000 inhabitants in 2020. By contrast, the number of follow-up contacts, both per 1000 inhabitants and per index contact, was higher in 2020. The composition of both index and follow-up contacts changed as the share of remote contacts, in particular for traditional care providers, increased.

CONCLUSIONS

During the COVID-19 pandemic in 2020, fewer index contacts for RTIs but more follow-up contacts were conducted, compared with 2018-2019. The share of both index and follow-up contacts that were conducted remotely increased. Further studies are needed to study the reasons behind the increase in remote contacts, and if it will last after the pandemic, and more clinical guidelines for remote assessments of RTI are warranted.
Re-engineering a Clinical Trial Management System Using Blockchain Technology: System Design, Development, and Case Studies (Preprint)
Authors: Zhuang Yan , Zhang Luxia , Gao Xiyuan , Shae Zon-Yin , Tsai Jeffrey J P , Li Pengfei , Shyu Chi-Ren
Published: February 2022

BACKGROUND

A clinical trial management system (CTMS) is a suite of specialized productivity tools that manage clinical trial processes from study planning to closeout. Using CTMSs has shown remarkable benefits in delivering efficient, auditable, and visualizable clinical trials. However, the current CTMS market is fragmented, and most CTMSs fail to meet expectations because of their inability to support key functions, such as inconsistencies in data captured across multiple sites. Blockchain technology, an emerging distributed ledger technology, is considered to potentially provide a holistic solution to current CTMS challenges by using its unique features, such as transparency, traceability, immutability, and security.

OBJECTIVE

This study aimed to re-engineer the traditional CTMS by leveraging the unique properties of blockchain technology to create a secure, auditable, efficient, and generalizable CTMS.

METHODS

A comprehensive, blockchain-based CTMS that spans all stages of clinical trials, including a sharable trial master file system; a fast recruitment and simplified enrollment system; a timely, secure, and consistent electronic data capture system; a reproducible data analytics system; and an efficient, traceable payment and reimbursement system, was designed and implemented using the Quorum blockchain. Compared with traditional blockchain technologies, such as Ethereum, Quorum blockchain offers higher transaction throughput and lowers transaction latency. Case studies on each application of the CTMS were conducted to assess the feasibility, scalability, stability, and efficiency of the proposed blockchain-based CTMS.

RESULTS

A total of 21.6 million electronic data capture transactions were generated and successfully processed through blockchain, with an average of 335.4 transactions per second. Of the 6000 patients, 1145 were matched in 1.39 seconds using 10 recruitment criteria with an automated matching mechanism implemented by the smart contract. Key features, such as immutability, traceability, and stability, were also tested and empirically proven through case studies.

CONCLUSIONS

This study proposed a comprehensive blockchain-based CTMS that covers all stages of the clinical trial process. Compared with our previous research, the proposed system showed an overall better performance. Our system design, implementation, and case studies demonstrated the potential of blockchain technology as a potential solution to CTMS challenges and its ability to perform more health care tasks.

CLINICALTRIAL
Familiarity in Rural Life: Protocol for a Scoping Review and Concept Analysis (Preprint)
Authors: Swan Marilyn A , Gietzen Luke J , Hobbs Barbara B
Published: February 2022

BACKGROUND

Familiarity is a concept often used in literature but is not well defined or understood. As a key concept in rural nursing theory, the conceptual understanding of familiarity is currently incomplete. The findings from this scoping review will inform a concept analysis using Walker and Avant’s method and to identify and define the missing key components of familiarity.

OBJECTIVE

The objective of this scoping review is to examine and analyze what is known in the existing literature about the concept of familiarity.

METHODS

The Joanna Briggs Institute scoping review framework guided the identification of literature published from 2016 to 2022 on familiarity. Following the PRISMA-ScR (Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews) reporting standard, the familiarity scoping review is registered on Open Science Framework (registration digital object identifier: 10.17605/OSF.IO/ZB8VF). A total of 8 databases, including PubMed, CINAHL (Cumulative Index to Nursing and Allied Health Literature) Plus with full text, APA PsychInfo, Communication Source, EBSCO MegaFILE, Medline, Nursing & Allied Health Database, and ScienceDirect, will be searched for 22 search terms. Covidence software will be used to manage the scoping review with each citation independently reviewed by 2 research team members for eligibility. Eligibility will be determined using a 2-level process. Each title and abstract will be screened for eligibility; for citations deemed eligible, a full-text article review will be conducted. The scoping review is expected to locate a large body of literature, and eligibility criteria will be refined during the title and abstract screening process. In addition, reference list scanning will be performed to locate relevant literature.

RESULTS

Familiarity data will be collected beginning October 2021 with anticipated completion in March 2022. Dissemination of findings will occur through scholarly presentations and in rural-focused and nursing publications in 2022 or 2023. The findings from this review will further the understanding of familiarity and how it affects rural life and nursing practice.

CONCLUSIONS

This review will support a full understanding and add clarity to the concept of familiarity as a component of rural life. These new insights will advance the understanding of how familiarity influences rural health care practice. The concept analysis will provide theoretical support for rural nursing theory and promote an understanding of the interrelationships of rural concepts.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/36930
Звернення головного редактора
Authors: Yevtushenko S.К.
Published: February 2022

No abstract
Сучасні аспекти диференціальної діагностики й лікування хронічного болю в нижній частині спини
Authors: Kopchak O.O.
Published: February 2022

У статті висвітлено актуальність проблеми хронічного болю в нижній частини спини, описано диференціальну діагностику механічного неспецифічного болю в нижній частині спини, подано особливості диференціальної діагностики синдрому ураження крижово-клубового суглоба як причини болю в нижній частині спини. На засадах доказової медицини висвітлено особливості діагностичного й лікувальних підходів до терапії пацієнтів з хронічним болем у нижній частині спини.