bluuebunny/crossref_metadata_2025 huggingface dataset:
Pembuatan Sabun Cair Cuci Piring untuk Pengembangan Wirausaha Karang Taruna di Pondok Ungu Permai Sektor V, Babelan, Bekasi Utara
Authors: Turseno Andi , Rosihan Rifda Ilahy , Nugroho Oki Widhi , Aji Sonny Nugroho , Sumanto
Published: January 2022

Kebutuhan akan sabun cuci piring cair meningkat dikarenakan beberapa masyarakat mulai beralih yang semula menggunakan sabun berbentuk krim sebagai sabun untuk mencuci piring kini beralih ke sabun cuci piring cair. Selain itu, penggunaan dari sabun cuci piring cair lebih mudah dan efektif dalam membersihkan noda pada peralatan dapur. Bahan dasar dari sabun cuci piring cair adalah senyawa kimia Surfactan yang memiliki fungsi sebagai pengangkat noda pada peralatan dapur. Tujuan dari pengabdian kepada masyarakat ini adalah untuk memberikan ilmu kepada karang taruna dalam hal pembuatan sabun cair untuk mengembangkan wirausaha Karang taruna di Ponduk Ungu Permai Sektor V, Babelan Bekasi Utara. Metode yang digunakan dalam kegiatan pengabdian kepada masyarakat ini adalah diskusi, pemaparan, sharing ilmu, dan praktik pembuatan sabun cuci piring. Hasil dari pengabdian kepada masyarakat ini berupa produk jadi sabun cuci piring cair sesuai dengan metode yang diberikan.
Solidarity Economy Reintegration Entities in Warmia and Mazury
Authors: Łojko Majka
Published: January 2022

The aim of the paper is to present solidarity economy reintegration entities and to analyse the actions they undertake for labour market reintegration and social inclusion of people at risk of social exclusion and for social and vocational rehabilitation of the disabled in the Warmia and Mazury region. The paper provides a review of the literature on the subject, based on an analysis of data from public statistics published by Statistics Poland, current studies of the Regional Centre of Social Policy in Olsztyn and scientific studies dedicated to the field of the social and solidarity economy.
The analysis has revealed that all solidarity economy entities operating in the region are focused on taking comprehensive measures aimed at counteracting social exclusion and promoting social and vocational reintegration of people who, for various reasons, are not able to perform their social and professional roles independently and effectively.
Features of modeling and construction of the information system of remote monitoring of the technical condition of vehicles
Authors:   Kherson State Maritime Academy, Khudiakov Igor , Gritsuk Igor ,   Kherson State Maritime Academy, Chernenko Valentina ,   Kherson State Maritime Academy, Gritsuk Yriy ,   Donbass National Academy of Civil Engineering and Architecture, Pohorletskyi Dmytro ,   Kherson State Maritime Academy, Makarova Tamara ,   Vinnitsa National Technical University, Manzhelei Viktor ,   Kherson State Maritime Academy
Published: January 2022

The article presents the features of construction and modeling of the system of operational remote monitoring of the technical condition of the truck in operation, and ensuring the interaction of monitoring data of the technical condition of the vehicle, trailer, mode of operation and rest of the driver and physical condition of the driver. The peculiarity of the vehicle monitoring information system equipped with the means of registration, mode of work and rest of the driver and physical condition of the driver is that it considers the features of remote inspection of the mode of work and rest of the driver and physical condition of the driver in the modern information and communication complex. means. The on-board intelligent diagnostic complex allows to measure in the conditions of operation a large number of parameters of the vehicle with the internal combustion engine and to carry out their registration on the remote computer with use of possibilities of the claimed method. As a result of forming a model of information system for monitoring the technical condition of the vehicle, it is possible to simultaneously monitor the parameters of the vehicle, provide remote inspection of driver's work and rest, physical condition of the driver, environmental performance of the vehicle, speeding. The process of formation and analysis of information structures of information-analytical system of operative control of technical condition of vehicle in operating conditions (Systems of Operative Control of a Technical Condition of the Vehicle in Operating Conditions) is considered. The effectiveness of the remote monitoring information system is enhanced by the possibility of prompt adjustment of the level of negative impact of motor vehicles on the environment and road infrastructure.
EFFICIENCY OF FIRST GENERATION RETINOIDS IN THE TREATMENT OF III AND IV GRADE OF ACNE FOR IMPROVING EMOTIONAL STATUS
Authors: Bezeha O. , Vasylyeva K. , Yemchenko Ya. , Oliynichenko Ya.O.
Published: January 2022

Acne (acne vulgaris) is a chronic, widespread, multifactorial disease manifested by open and closed comedones, inflammatory skin lesions in the form of papules, pustules and nodes. Emotional reactions are the most characteristic manifestations of human mental activity, which are accompanied by autonomic and endocrine changes associated with the release of various hormones: primarily stress hormones and androgens. Antibiotics have been effective and widely used for the past four decades. However, worldwide, there is an increase in antibiotic resistance due to their frequent and prolonged use. Retinoids are currently one of the most effective groups of drugs used to treat acne. The aim of our study is to investigate the efficacy of the first generation retinoids (isotretinoin) in the treatment of third and fourth degree acne in order to improve emotional status of patients. Patients received Isotretinoin in a starting dose of 0.5 mg / kg of body weight during meals, dose adjustment was carried out after 1 month at the rate of 0.5-0.75 1.0 mg / kg of body weight, the duration of treatment was assessed by gaining the commutative dose of 120 mg / kg of body weight, and the treatment duration lasted 16-24 weeks. After 3 months, the majority of patients 26 (89.66%) noted the disappearance of the rash completely, and 3 (10.34%) found only single papular-pustular elements. At the end of the therapy course with isotretinoin, complete clinical remission was achieved in all patients and the emotional load completely disappeared, self-esteem increased, disbelief in a positive result faded in 25 (96.15%) of 26 patients in the "Depressive" category.
EFFECT OF ANDROGENS ON IMMUNE CELLS
Authors: Martynenko R.V. , Stetsuk Ye.V. , Shepitko V.I. , Boruta N.V. , Yakushko O.S.
Published: January 2022

I recent years, much attention of researchers has been paid to the role of testosterone in the regulation of immune cells and its influence on the course of autoimmune diseases and inflammatory diseases. Better understanding of testosterone-regulated cellular and molecular pathways and the role of androgens in stimulating tissue-specific differences in inflammation susceptibility can lead to the development of innovative treatment strategies for a variety of diseases depending on gender. The aim of this study is to analyze the latest research on the effect of androgens on immunocompetent cells. Sex differences in the functions of the immune system are genetically determined and mediated by the action of male and female sex hormones. Myeloid immune cells express sex hormone receptors and are sensitive to sex hormones. Androgens, including dihydrotestosterone and testosterone, inhibit the activity of immune cells. Effects of testosterone restricts the activity of NK cells, the surface expression of TLR4 on macrophages, the synthesis of proinflammatory products, including TNF-α and nitric oxide synthase, and the formation of leukotriene in neutrophils. Androgens also affect inducing stimuli that regulate the activity of monocyte-macrophages. Testosterone controls complement activation. Androgens have a suppressive effect on the expression of proinflammatory cytokines, reduce the production of prostaglandin E2 in monocytes. The presence of androgen receptors is important factor in regulating neutrophil differentiation. Androgen receptors regulate, first of all, the transition between the proliferation of precursors (myeloblasts, promyelocytes and myelocytes) and the maturation of neutrophils (metamyelocytes, band and segmented neutrophils). The number and activity of cells associated with innate immunity differ between the sexes. Males have a higher natural killer (NK) percentage than females. Phagocytic activity of neutrophils and macrophages in women is higher than in men. Antigen-presenting cells in women are more efficiently presented by peptides than in men. Sex differences are also observed in innate lymphoid cells, which are lymphocytes that regulate a number of tissue immune responses by producing effector cytokines.
GIANT MUCOCELE OF THE APPENDICULAR PROCESS
Authors: Kalyuzhka A.S. , Sheiko V.D. , Shatalin B.O. , Cherkun O.Y.
Published: January 2022

This article presents the analysis of a rare clinical case of treatment of a patient with mucinar cystadenoma of the appendix. It has been demonstrated that the clinical course of this disease, as a rule, does not have a clear specific clinical picture, but most often it is clinically similar to chronic appendicitis, ovarian cysts, tumours of the abdominal cavity, and intestinal colic. Despite the progress in the radiological diagnosis of diseases of the abdominal organs, the diagnosis of mucocele of the appendix is extremely rare. The paper presents a case of treatment of a female patient who was admitted to M.V. Sklifosovsky Poltava Regional Clinical Hospital for emergency with suspected acute appendicitis. Following pre-operative examination, the patient was diagnosed as having “Acute appendicitis. Appendicular abscess”, and according to urgent indications the patient was operated on. The extent of surgical operation included appendectomy, drainage of the abdominal cavity. The macroscopic preparation was sent for a histopathological examination, where the diagnosis of "Mucinar cystadenoma of the vermiform appendix" was established. The patient was discharged from the surgical department in satisfactory condition on the 7th day. Considering that in every fifth patient, mucocele of the appendix is combined with synchronous or metachromic cancer of the colon, and in 4-24% of cases with cancer of the ovaries, gallbladder, thyroid and breast, the patient is further subject to strict examination and observation. Therefore, the problem of detecting mucocele of the appendix is relevant and requires additional investigation for diagnosis and differential diagnosis with other cystic formations of the abdominal organs.
CLINICAL AND LABORATORY PREDICTORS OF PAIN SYNDROME PERSISTENCE IN ELDERLY AND SENILE PATIENTS DURING LATE POSTOPERATIVE PERIOD
Authors: Telegan V.O.
Published: January 2022

Changes in neurohumoral regulation and emotional perception of nociceptive impulses in elderly and senile patients result in some clinical peculiarities of pain syndrome manifestation. Recent studies have shown that more than 10% of geriatric patients experience pain not only as an irritant but also as a psychosomatic condition. Persistence of pain in the postoperative period in the elderly and senile patients can turn into its catastrophic and chronic character in the future thus impacting the quality of life of patients and increasing the health care economic expenses to provide the proper chronic pain management. Therefore, the aim of this study is to determine the main predictors of pain persistence in the elderly and senile patients in the late postoperative period. The study included 201 male and female patients who underwent surgery regardless of surgical profile. All patients were divided into 3 groups according to age: group 1 (n = 82) included the elderly individuals, group 2 (n = 21) included senile individuals, and the control group (n = 98) included the adult patients.

To evaluate the presence and severity of pain syndrome, pain assessment was performed by applying 100-score visual-analog scale in 1 and 7 days. A detailed study of the perception of postoperative pain was performed by the McGill questionnaire, which was used only on day 7, because on day 1 patients could be weakened after surgery, and the results distorted by the action of drugs. All examined patients were measured for fasting cortisol in the morning on the 1st and 7th day. The blood collection procedure was performed according to the general requirements for medical and biological tests. Blood was drawn from a vein by a nurse in the direct presence of a doctor. The serum cortisol content was determined using a set of reagents for quantitative enzyme-linked immunosorbent assay. The study has demonstrated that age, score on the visual-analog scale and the evaluation scale of the McGill questionnaire for day 7, as well as blood cortisol concentration in day 1 after surgery are of definite prognostic value for the risk of persistence of postoperative pain syndrome. The chance of persistence of postoperative pain increases in 1.1 times for each year in older patients, 1.3 times for each score according to the visual-analog scale for 7 days, and in 11.4 times for each score on the evaluation scale of the McGill questionnaire, and in 2.4 times for each nmol/l of cortisol concentration in 1 day after surgery. Thus, the determined risk factors for persistence of postoperative pain include the patient's age, assessment of pain by applying a visual-analog scale, and the evaluation scale by the McGill questionnaire for 7 days and the concentration of blood cortisol in 1 day after surgery.
Anomia COVID-19. Próba identyfikacji zjawiska
Authors: Zdun Magdalena
Published: January 2022

Zjawisko anomii należy wiązać z okresami przejścia, zwłaszcza ze zmianami o charakterze gwałtownym. Szczególnym rodzajem tego typu zmian są następstwa klęsk czy kataklizmów, w tym epidemii. Szerząca się choroba wystawia na próbę nie tylko system zabezpieczeń materialnych, lecz także skutkuje aksjonormatywną przebudową społeczeństwa. Ostatecznie też prowokuje pytanie o możliwość wypracowania właściwej dla tej sytuacji „nadrzędności aksjologicznej”. Scenerią urzeczywistnienia się współczesnej anomii jest pandemia COVID-19. Pełna diagnoza tego fenomenu wymaga dłuższego dystansu czasowego. Analizy ex ante powinny koncentrować się na skonstruowaniu odpowiedniego narzędzia diagnozy. Taki też jest cel niniejszego artkułu.
ECONOMIC AND FISCAL CONSEQUENCES OF THE COVID-19 PANDEMIC: THE CASE STUDY OF NORTH MACEDONIA
Authors:   South East European University, North Macedonia, Osmani Rufi
Published: January 2022

This paper aims to analyse the impact of Covid-19 on economic and fiscal consequences in North Macedonia. In addition, the paper assesses the effects of economic and fiscal packages implemented by the Government of the country. The study uses secondary data in order to find out the real consequences caused by Covid-19 pandemic in the economy of North Macedonia. The findings reveal thatCovid-19 pandemic produced negative economic and fiscal consequences during 2020 in all sectors. Moreover at the end of 2020 the real sector of the economy recorded a 4.5% decline in GDP, the fiscal deficit achived a level of -8.1% of the GDP. The findings of the paper show that government assistance through various packages, partly affected the reduction of negative economic consequences of Covid-19.
IMPLEMENTATION OF A QUALITY STRATEGY BASED ON CUSTOMER SATISFACTION ANALYSIS. CASE STUDY: HOTEL MARKET
Authors:   Transilvania University of Brașov, Madar Anca
Published: January 2022

The quality of services in hotel management is crucial for the development of brand value and the growth of the customer base. Every hotel should strive not only to improve the quality of services, but also to exceed customer expectations. Such a mentality is very beneficial especially for the field of hospitality management, where competition is constantly increasing.In light of this, a research was carried out, in order to evaluate the quality of services provided within the Alpin hotel unit so that the company can acknowledge customer dissatisfaction and implement the appropriate quality strategy towards positive outcomes
REVALUATION OF THE TANGIBLE ASSETS – OPTION ACCESSIBLE TO COMPANY MANAGERS
Authors:   Transilvania University of Brașov, Anton Carmen Elena
Published: January 2022

Accounting policies are access ways which companies can use to fulfil the development strategies envisaged. According to the accounting regulations currently applicable in Romania, the accounting policies are specific to each company and subject to approval by the management, and they are constantly applied from one financial year to another. The revaluation of the tangible assets is part of the options available to managers. Nevertheless, their implementation is based on a prior analysis of the impact on performance. The aim of this paper is to identify the influences that this accounting policy has on the company’s performance
THE COMMON SYSTEM ON THE VALUE ADDED TAX OF THE EUROPEAN UNION APPLIED TO THE INTRA-COMMUNITY OF PURCHASES OF MOTOR VEHICLES
Authors:   Transilvania University of Brașov, Busuioceanu Steliana
Published: January 2022

The common system of value added tax (VAT) of the European Union (EU) is implemented through Directive 2006/112/EC amending the text of Directive 6, namely of Council Directive 77/388/EC of May 17th 1977 to clarify the existing EU VAT legislation. This tax applies to all transactions made in the EU by a natural person or a legal entity called a taxable person, who provides goods and services in the course of their business. Moreover, imports of goods and services by any taxable person are also subject to VAT. The intra-community purchase of means of transport represents the entry into Romania of motor vehicles coming from member states of the European Union, goods that are transported from another member state to Romania. The fiscal treatment is very different depending on the specifics of each particular circumstance at the intra-community purchase and it is regulated by Title VI of the Tax Code which transposes the provisions of Directive 2006/112/EC. We aim at analyzing and capturing the accounting and fiscal diversity generated by these particular circumstances in the intra-community purchase of motor vehicles.
Quantitative development and structure of zoobenthos in channels on the left margin of the Selenga River delta
Authors: Matafonov P.V. ,   Institute of Natural Resources, Ecology and Cryology, Siberian Branch of the Russian Academy of Sciences, Nedorezova Str., 16a, Chita, 672014, Russia, Matafonov D.V. ,   Russian Federal Research Institute of Fisheries and Oceanography, Baikal Branch, Khakhalova, 4b, Ulan-Ude, 670034, Russia
Published: January 2022

Abstract. There are only a few studies on zoobenthos in the delta of the Selenga River located at the junction of Lake Baikal and its largest tributary. The present work provides the results of research on zoobenthos in the southern (left) Selenga delta channels in 2002. Baikal amphipods and bivalves are widespread up to the upper delta. The direction and velocity of the water flow in the delta induced change of a river zoobenthos complex for a limnophilous one. Baikal amphipods are responsible for high quantitative indicators of zoobenthos in the southern channels of the delta. Low parameters of quantitative development of zoobenthos were registered during summertime. Organic matter from the catchment area of the Selenga River provides trophic resources for zoobenthos. Amphipods, bivalves and oligochaetes are involved in the transformations of suspended, sedimented and buried fractions of allochthonous matter. The authors obtained evidence on maintenance of the principal properties of the delta ecosystem as an ecotone at the time of research.
Down-regulation of MEG3, PANDA and CASC2 as p53-related lncRNAs in breast cancer
Authors: Ghafouri-Fard Soudeh , Sohrabi Behnoush , Hussen Bashdar Mahmud , Mehravaran Elham , Jamali Elena , Arsang-Jang Shahram , Fathi Mohadeseh , Taheri Mohammad , Samsami Majid
Published: January 2022

TP53 encodes a major tumor suppressor protein which blocks carcinogenesis process in a variety of tissues including breast tissue. Expression and function of this gene is regulated by a number of long non-coding RNAs (lncRNAs) among them are PANDA, MEG3 and CASC2. We measured expression of TP53 and these transcripts in a cohort of Iranian breast cancer patients. Expression levels of TP53, MEG3, CASC2 and PANDA were significantly lower in tumoral samples compared with non-tumoral samples (Posterior mean differences =  −4.26, −1.66, −5.98 and −3.13, respectively; P values < 0.0001). Expression of CASC2 was higher in Her2 1+ cases compared with Her2 negative cases (Beta = 1.85, P value = 0.037). Expression levels of MEG3 and TP53 were lower in grade 2 samples compared with grade 1 (Beta = −1.86, P value = 0.006 and Beta = −2.24, P value = 0.003, respectively). There was no other significant association between expression of genes and clinical variables. CASC2 had the best performance among these genes with area under curve value of 0.78 and sensitivity and specificity values of 56.33% and 88.73%, respectively (P value < 0.0001). The current investigation supports the role of TP53-related lncRNAs in the pathogenesis of breast cancer.
Predictors of Life Expectancy in Autopsy-Confirmed Alzheimer’s Disease1
Authors: Schaffert Jeff , LoBue Christian , Hynan Linda S. , Hart John , Rossetti Heidi , Carlew Anne R. , Lacritz Laura , White Charles L. , Cullum C. Munro
Published: January 2022

Background: Life expectancy (LE) following Alzheimer’s disease (AD) is highly variable. The literature to date is limited by smaller sample sizes and clinical diagnoses. Objective: No study to date has evaluated predictors of AD LE in a retrospective large autopsy-confirmed sample, which was the primary objective of this study. Methods: Participants (≥50 years old) clinically and neuropathologically diagnosed with AD were evaluated using National Alzheimer’s Coordinating Center (N = 1,401) data. Analyses focused on 21 demographic, medical, neuropsychiatric, neurological, functional, and global cognitive predictors of LE at AD dementia diagnosis. These 21 predictors were evaluated in univariate analyses. Variables found to be significant were then entered into a forward multiple regression. LE was defined as months between AD diagnosis and death. Results: Fourteen predictors were significant in univariate analyses and entered into the regression. Seven predictors explained 27% of LE variance in 764 total participants. Mini-Mental State Examination (MMSE) score was the strongest predictor of LE, followed by sex, age, race/ethnicity, neuropsychiatric symptoms, abnormal neurological exam results, and functional impairment ratings. Post-hoc analyses revealed correlations of LE were strongest with MMSE ≤12. Conclusion: Global cognitive functioning was the strongest predictor of LE following diagnosis, and AD patients with severe impairment had the shortest LE. AD patients who are older, male, white, and have more motor symptoms, functional impairment, and neuropsychiatric symptoms were also more likely have shorter LE. While this model cannot provide individual prognoses, additional studies may focus on these variables to enhance predictions of LE in patients with AD.
MSR1 and NEP Are Correlated with Alzheimer’s Disease Amyloid Pathology and Apolipoprotein Alterations
Authors: Miron Justin ,   for the PREVENT-AD research group, Picard Cynthia , Labonté Anne , Auld Daniel , Poirier Judes
Published: January 2022

Background: In mouse models of amyloidosis, macrophage receptor 1 (MSR1) and neprilysin (NEP) have been shown to interact to reduce amyloid burden in the brain. Objective: The purpose of this study is to analyze these two gene products in combination with apolipoproteins and Aβ1-42 in the cerebrospinal fluid (CSF) and plasma of individuals at different stages of Alzheimer’s disease (AD), as well as in autopsied brain samples from ROSMAP (Religious Orders Study and Memory and Aging Project). Methods: CSF/plasma levels of MSR1 and NEP were measured using the sensitive primer extension assay technology. CSF Aβ1-42 was assessed with ELISA, while CSF ApoE and ApoJ were measured with the Luminex’s multiplex technology. Brain MSR1, APOE, and CLU (APOJ) mRNA levels were measured with RNA-Seq and contrasted to amyloid plaques pathology using CERAD staging. Results: While plasma and CSF MSR1 levels are significantly correlated, this correlation was not observed for NEP. In addition to be highly correlated to one another, CSF levels of both MSR1 and NEP are strongly correlated with AD status and CSF Aβ1-42, ApoE, and ApoJ levels. In the cortical tissues of subjects from ROSMAP, MSR1 mRNA levels are correlated with CLU mRNA levels and the CERAD scores but not with APOE mRNA levels. Conclusion: The discrepancies observed between CSF/plasma levels of MSR1 and NEP with CSF Aβ1-42 and ApoE concentrations can be explained by many factors, such as the disease stage or the involvement of the blood-brain barrier breakdown that leads to the infiltration of peripheral monocytes or macrophages.
Predicting preeclampsia course based on endothelium-dependent dilation
Authors:   I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Shavaeva R.Kh. , Murashko A.V. ,   I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Zuev V.M. ,   I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Timofeev S.A. ,   I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Dzhibladze T.A. ,   I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: January 2022

Aim: to determine prognostic criteria of severe preeclampsia based on the assessment of endothelium-dependent (ED) flow-mediated dilation (FMD) of the brachial artery (BA). Patients and Methods: 97 pregnant women (>28 weeks of pregnancy) with moderate preeclampsia were enrolled. These women were retrospectively divided into two groups. Group 1 included 42 pregnant women (mean age 30.0±0.5 years) in whom the severity of preeclampsia increased after treatment. Group 2 included 55 pregnant women (mean age 31.0±0.7 years) whose severity of preeclampsia did not increase after treatment. Group 3 (control group) included 20 women with a healthy pregnancy. ED FMD of BA was assessed by vascular ultrasound using a reactive hyperemia test. In addition, BA diameter and peak systolic velocity (PSV) 15 sec and 1 min after cuff deflation were measured. These measurements were performed at enrollment and after one week (or in feeling worse). Results: healthy pregnancy was characterized by a gradual increase in BA diameter in response to cuff inflation (by 15.7% and 23.9% after 15 sec and 1 min, respectively, at baseline and by 17.8% and 21.3% after 15 sec and 1 min, respectively, after one week). In pregnant women with preeclampsia, baseline changes in BA diameter were less significant. Meanwhile, after one week, a reduction in BA diameter was reported in group 1, and close-to-normal BA diameter was reported in group 2. In group 3, BA PSV increased by 5.2% and 16% in 15 sec and 1 min, respectively, after cuff inflation. In pregnant women with preeclampsia, BA PSV, in contrast, was reduced (more significant after 1 min). Conclusion: increased BA diameter and PSV by less than 10% 15 sec and 1 min after cuff inflation indicate endothelial dysfunction. A negative pattern of changes in these parameters suggests an unfavorable course of preeclampsia and its transition to severe disease. KEYWORDS: preeclampsia, endothelial dysfunction, vasodilation, brachial artery, peak systolic velocity, prognosis. FOR CITATION: Shavaeva R.Kh., Murashko A.V., Zuev V.M. et al. Predicting preeclampsia course based on endothelium-dependent dilation. Russian Journal of Woman and Child Health. 2021;4(4):317–321 (in Russ.). DOI: 10.32364/2618-8430-2021-4-4-317-321.
Genital endometriosis: pathogenesis, diagnosis, and association with malignancies
Authors:   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Il’ina I.Yu. , Burdin D.V. ,   N.I. Pirogov City Clinical Hospital No. 1, Moscow, Russian Federation, Narimanova M.R. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Ibragimova D.M. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: January 2022

Endometriosis is a hormone-dependent genetic disease that develops in impaired immune homeostasis. However, its pathogenesis remains an enigma. It is known that eutopic endometrium in women with endometriosis is different from that in healthy women. Morphologic examination of eutopic endometrium sample allows diagnosing endometriosis at an early stage. To date, the association between endometriosis and the risk of malignancies is in strong focus. Endometriosis is a benign disorder but shares similarities with malignancies, e.g., apoptosis resistance and stimulation of angiogenesis. Recent findings suggest that endometriosis is a precursor of clear cell and endometrioid ovarian cancer. Further studies are needed to identify novel markers of endometriosis for its timely diagnosis. Timely and adequate therapy reduces the prevalence of ovarian tumors. Further development of molecular studies on endometriosis and ovarian cancer predictors will uncover pathogenic mechanisms and find potential preventive and treatment modalities. KEYWORDS: endometriosis, ovarian cancer, eutopic endometrium, ectopic endometrium, apoptosis, angiogenesis. FOR CITATION: Il’ina I.Yu., Burdin D.V., Narimanova M.R., Ibragimova D.M. Genital endometriosis: pathogenesis, diagnosis, and association with malignancies. Russian Journal of Woman and Child Health. 2021;4(4):339–345 (in Russ.). DOI: 10.32364/2618-8430- 2021-4-4-339-345.
Solid wastes management, Biogas and compost generated from organic waste at Al-Akaider landfill in Jordan
Authors: al Ajlouni Mohammad Fawzi , KHATTAB Mohammed
Published: January 2022

Jordan has been facing a wide variety of sudden changes in humanitarian issues (population growth, industrialization rapid, urbanization process, influx of refugees to Jordan etc.). These unexpected changes forced people to make quick reactions to adapt and settle, which resulted in further generation of solid waste which normally was dumped in landfills and caused contamination of soil, water and air. Solid Waste Management (SWM) has been an integral part of every human society. Improper SWM accelerates natural resources degradation and has a great impact on climate change and the quality of life of citizens. Hence, in this paper, we highlight the environmental and health problems of the Al-Akaider landfill in Jordan. We propose a multi-pronged integrated approach to improve solid waste management at the Al Ekaider landfill. In keeping with this approach, a general action plan has been proposed that could be tailored to recycle Organic Waste (OW) to produce biogas and compost.

              © 2018 JASET, International Scholars and Researchers Association
БИОКОНВЕРСИЯ ТРИТЕРПЕНОИДОВ ОЛЕАНАНОВОГО ТИПА АКТИНОБАКТЕРИЯМИ
Authors: Лучникова Наталья Алексеевна , Иванова (Кудымова) Ксения Михайловна , Тарасова Екатерина Владимировна , Гришко Виктория Викторовна , Ившина Ирина Борисовна
Published: January 2022

С использованием биоресурсов Региональной профилированной коллекции алканотрофных микроорганизмов (официальный акроним ИЭГМ; номер во Всемирной федерации коллекций культур 285, www.iegmcol.ru) показана способность актинобактерий рода Rhodococcusк окислительной конверсии 1,0 г/л растительных пентациклических тритерпеноидов ‒ олеаноловой (ОК) и глицирретовой (ГК) кислот. Отобран штамм R. rhodochrous ИЭГМ 1360 с высокой каталитической активностью, катализирующий в течение 7 сут образование 3-оксоолеан-12-ен-28-овой (0,9%) и 3,11-диоксо-олеан-12-ен-29-овой (26,1%) кислот из ОК и ГК соответственно. Экспериментально обосновано, что в процессе биотрансформации ОК и ГК участвуют ферментные комплексы, прочно связанные с клеточной мембраной актинобактерий. По данным фазово-контрастной микроскопии, родококки формируют обособленные клеточные агрегаты на поверхности субстратов. При этом значительного изменения размеров их клеток не выявлено. Полученные данные расширяют представление о каталитической активности актинобактерий рода Rhodococcus и их возможном использовании в качестве биокатализаторов процессов биоконверсии гидрофобных полициклических субстратов, в том числе перспективных в синтезе биологически активных соединений ОК и ГК.
ОЦЕНКА НАУЧНОГО ТВОРЧЕСТВА Г. Ф. КАРПОВА (1839–1890) В ИСТОРИОГРАФИИ
Authors: Ившин Владислав Сергеевич
Published: January 2022

В статье анализируется историографическая оценка научно-исследовательского наследия Г. Ф. Карпова по истории «Малой России». Делается вывод об ангажированности историографов и дихотомии настоящих оценок его наследия в историографии, а также отмечаются перспективы дальнейший актуализации его исторического наследия.
НЕФТЕГАЗОПРОЯВЛЕНИЯ В КУРГАНСКОЙ ОБЛАСТИ
Authors: Леонтьев Дмитрий Сергеевич , Арсеньев Алексей Аркадьевич
Published: January 2022

В настоящей статье проведен анализ перспектив нефтегазоносности Курганской области. На основании обобщения опубликованных данных приведены факты естественных нефтегазопроявлений в Шаринском, Кетовском и Звериноголовском районах Курганской области. Проявление углеводородов при бурении Курганской параметрической скважины № 1. В результате бурения и испытания скважины, промыслово-геофизических исследований, проведения анализов кернового материала, проб воды и газа получены данные, подтверждающие наличие коллекторов в зоне контакта мезозойских и палеозойских отложений и надежных покрышек над ними. Отмеченное нефтепроявление в этой зоне, позволяет сделать вывод о возможных промышленных скоплениях углеводородов при наличии благоприятных структурных условий.
СОВЕРШЕНСТВОВАНИЕ СИСТЕМЫ УПРАВЛЕНИЯ ИНТЕЛЛЕКТУАЛЬНЫМ КАПИТАЛОМ ПРЕДПРИЯТИЯ НА ОСНОВЕ РЕНТНОГО ПОДХОДА
Authors: Дмитриев Николай Дмитриевич
Published: January 2022

Настоящая статья посвящена рассмотрению системы управления интеллектуальным капиталом предприятия с помощью использования методики оценки рентного дохода. В результате адаптации рентного подхода к оценке результативности хозяйственной деятельности возможно определить значимость интеллектуального компонента в итоговом сверхнормативном доходе предприятия. Для этого предлагается использовать авторскую методику для оценки уровня интеллектуальной ренты, на основе которой возможно определить уровень интеллектуализации предприятия и разработать мероприятия по управлению его интеллектуальным развитием. Таким образом, предложенный подход позволяет рационализировать процессы интеллектуализации, направив их на максимизацию эффективности деятельности предприятия за счет определения результативности его рентных доходов.
Is Home-Host Cultural Distance a Risk? Evidence from Outward Foreign Direct Investment by Chinese Enterprises
Authors: Su Hang , Fu Yao
Published: January 2022

Cultural distance is always regarded as a “risk” in the decision making of enterprises involved in the outward foreign direct investment (OFDI), however, investment is a powerful driver of productivity growth and increased innovation capacity of enterprises in both countries. Is cultural distance a “risk” ? Using Hofstede's indicators and the Kogut and Singh index (1988), this paper calculates the cultural distance based on six cultural dimensions and further examines the effect of cultural distance on the outward foreign direct investment by Chinese enterprises and its mediating effects on the role of other factors influencing the decisions of multinationals. The results indicate that there is a nonlinear effect of cultural distance and the mediating effect of cultural distance is negative.
Risk Factors for Coronary Artery Disease in Patients Undergoing Coronary Angiogram at a Tertiary Level Hospital in Nepal
Authors: Mishra Jeetendra , Karn Achutanand Lal , Singh Alok Kumar , Hussain Asraf , Ram Ramji , Kaushik Pratibha
Published: January 2022

Background: Ischemic heart disease is the leading cause of CVD health loss globally, as well as in each world region, followed by stroke.  In Nepal, CVD was found to be the second most common non-communicable disease among indoor patients of the non-specialist hospital. Age, gender, smoking, obesity, dyslipidemia, physical inactivity, hypertension, and diabetes mellitus (DM) are established risk factors for CVD.  In Nepal, hypertension is found to be the most prevalent risk factor for CVD.

Aims and Objectives: This study aimed to assess risk factors for coronary artery disease in patients undergoing coronary angiograms in Nepal. This study also investigated the socio-demographic characteristics of the participants and the nature of the involvement of coronary arteries.

Materials and Methods: We examined in this cross-sectional study a total of 74 patients who underwent coronary angiography (CAG) at National Medical College between May 2020 and June 2021. Patients were grouped according to the number of major epicardial coronary arteries involved in SVD, DVD, and TVD. Patients were checked for risk factors like smoking, diabetes mellitus, hypertension, dyslipidemia, family history of coronary artery disease, and obesity. Microsoft Office Excel and SPSS version 21.0 were used for data analysis. The study was approved by the ethical committee.

Results: Among 74 participants 53 were male. The mean age was 59.65±10.74 years. Premature coronary artery disease was present in six patients. SVD was the commonest CAD type. Hypertension was the commonest risk factor followed by Diabetes mellitus. Hypertension, Diabetes mellitus, Family history of premature CAD, and obesity were found to be statistically significant.

Keywords: CAD, Risk factors for CAD, Premature CAD, Hypertension, Diabetes, obesity, family history of CAD, dyslipidemia, Smoking, SVD, DVD, TVD, Nepal
Formulation and Characterization of Ziprasidone Floating Pellets
Authors: Kumar J Praveen , Harika S
Published: January 2022

The objective of this study is to design and evaluate Ziprasidone Floating pellets, which prolongs the release rate of the drug while extending the residence time of the drug within the body environment and without causing undeliterious effects to the subject. Ziprasidone and controlled matrix polymer granules were prepared by different granulation techniques in the ratio of 1:1, 1:1.5 and 1:2.Ziprasidone multi unit formulations comprising cellulose polymers were prepared by wet granulation technique, where as the Ziprasidone multi unit formulations comprising lipoidal / fatty polymers were prepared by melt granulation technique. Ziprasidone multi unit formulations with drug and polymer proportion as 1:1, F1 and F2 formulations consisting Cellulose polymers HPMC K4M and HPMC K100 respectively were prepared by wet granulation technique.

Keywords: Ziprasidone, wet granulation, Floating pellets, melt granulation and polymer.
China’s Psychological Implementation to Overcome COVID-19 Pandemic
Authors:   Department of Psychology, Northwest Normal University, China., Ahmed Md Zahir
Published: January 2022

N/A
Ethanolic Extract of Syzygium cumini Causes Toxic Effects on Ethanol-induced Liver and Kidney Damage in Albino Wistar Rats: A Biochemical and Histological Study
Authors:   Department of Human Anatomy, School of Basic Medical Sciences, University of Maiduguri, Maiduguri, Nigeria., Manu Abba Aji , Musa Bello Muhammad ,   Department of Human Anatomy, School of Basic Medical Sciences, University of Maiduguri, Maiduguri, Nigeria., Oche Attah Martha Orendu ,   Department of Human Anatomy, School of Basic Medical Sciences, University of Maiduguri, Maiduguri, Nigeria., Bedan Helga Ishaya ,   Department of Human Anatomy, School of Basic Medical Sciences, University of Maiduguri, Maiduguri, Nigeria.
Published: January 2022

Background: The therapeutic value of Syzygium cumini (S. cumini) has been documented in traditional medicine for the treatment of many diseases and ailments. Various preparations of this plant have been made and used especially for liver inflammatory conditions in livestock. Further, many liver diseases in humans are inflammatory conditions, which are caused by alcohol intake. This study sought to examine the effect of S. cumini on ethanol-induced hepatotoxicity in Wistar albino rats. Methods: Twenty-five rats were divided into five groups of five rats each. The first group was control and the other four were administered ethanol at varying doses to induce liver and kidney damages. Two doses of the S. cumini extract were administered at a concentration of 200 mg/kg or 400 mg/kg. Silymarin was administered to the last group at 10 mg/kg. The liver and kidney tissue samples were collected and preserved for histological analyses and the rat sera were analyzed for the associated biochemical biomarkers. Results: Histopathological analyses revealed pyknotic nuclei and distortion in the arrangement of the hepatocytes in extract-treated groups. The kidney tissue samples showed signs of interstitial bleeding and aggregation of lymphocytes in the peri-glomerular areas. The analyses of the biochemical parameters revealed that there were significant increases in the aspartate aminotransferase (AST), alanine transaminase (ALT), Urea and creatinine in the sera of the groups treated with the extract compared to those of the controls (P<0.05). Conclusion: The S. cumini extract caused elevation of serum hepatic and renal biomarkers at 400 mg/kg and did not have a hepatoprotective effect.
В.А. Ляшчынская, Два фрагменты фразе- алагічнай карціны свету беларусаў: манаграфія РІВШ, Мінск 2020, 230 с.
Authors: Шведава Зоя
Published: January 2022

Review
Evaluación de las características fisicoquímicas de yogurt con probiótico bifidobacterium spp. formulado con jalea de uvilla y harina de quinua
Authors: Estrella Erazo Fernanda Milena , Anchundia Lucas Miguel Ángel , Yambay Vallejo Wilman Jenny
Published: January 2022

La practicidad, conveniencia y cercanía en algunas ocasiones no están relacionadas con la adquisición de productos alimenticios nutritivos, debido a que los patrones alimentarios de ciertas industrias en la actualidad contienen altos porcentajes de grasas saturadas, sodio, azúcares y calorías. Por este motivo, los consumidores en la actualidad exigen al mercado productos sanos y de gran valor nutricional que aporten proteínas, grasas, vitaminas y minerales a la dieta diaria. En la presente investigación se evaluaron las características fisicoquímicas del yogurt con probiótico Bifidobacterium spp. formulado con jalea de uvilla (Physalis peruviana) y harina de quinua (Chenopodium quinoa), como una alternativa alimentaria. Para ello, se valoró dos niveles de jalea de uvilla 25 % y 30 %, y tres niveles de harina de quinua 0,6 %; 0,8 % y 1 %, frente a un tratamiento control 0 %, aplicando un diseño completamente al azar con arreglo factorial AxB. Se realizó seis formulaciones, las mismas que fueron evaluadas sensorialmente, eligiendo al tratamiento T5 (0,8 % de harina de quinua y 30 % de jalea de uvilla) como el más aceptado. En cuanto a las características fisicoquímicas se obtuvo un pH de 4,28 y acidez de 0,765 %; contenido de sólidos totales 23,47%; proteína 3,23 %; grasa 2,88 %; ceniza 0,79 %; fibra 1,82 %; carbohidratos 67,81 %; vitamina C 0,049 %; potasio 1245,03 mg/kg y calcio 738,23 mg/kg, por tanto, se concluye que es un producto nutritivo y saludable, apto para el consumo humano.
A giant leiomyoma of the breast
Authors: Shopov Spasimir Todorov
Published: January 2022

Breast leiomyoma is a rare benign tumor arising from the nipple and/or areola or from smooth muscle metaplasia of myoepithelial or myofibroblast cells. Despite its benign morphology, breast leiomyoma can create diagnostic confusion. Here, we report a rare case of a single leiomyoma of the breast in a 52-year-old woman. The patient reported a lump in her right breast for 1 year, and in the past 6 months, it has grown in size. Physical examination showed a dense mass in the right breast, without axillary lymphadenomegaly. Excisional biopsy revealed a well-defined cell tumor by intertwining the spindle cell folds with fibrillar and eosinophilic cytoplasm. Histopathological and immunohistochemical studies help to discriminate between leiomyoma and other benign and malignant breast lesions. Her results are discussed in our report.
The dual mediating effect of mindfulness and hope between gratitude and happiness of high school students in Korea: the moderated mediation effect of the growth mindset
Authors:   Hanseo University, Shin Eun Mi , Lee Chang Seek ,   Department of Health, Counseling and Welfare
Published: January 2022

Introduction. In Korea, high school students are very low in happiness because they possess many worries about better university entrance and career development. The purpose of this study was to focus on increasing happiness by examining whether the growth mindset moderates the dual mediating effects of mindfulness and hope between gratitude and happiness. Study participants and methods. The participants of this research were male (50.6%) and female (49.4%) among 435 high school students, and 86.2% of the participants lived in small and medium-sized cities, Dong and Eup. As for parental occupations, sales, service, and production jobs accounted for the most, at 32.2%. The household income level was medium for 51.0% of the participants, and 64.1% had dual-income parents. The SPSS Win. 25 and the PROCESS macro 3.5. were used for data analysis. Descriptive statistical analysis, reliability analysis, mean comparison analysis, and moderated mediation effect analysis were conducted. Results. First, there was significant positive correlation between all of the variables. Gratitude and happiness had the highest correlation coefficient (r=.494, p<.01), followed by mindfulness and happiness (r=.452, p<.01), and then gratitude and happiness (r=.451, p<.01). Second, the growth mindset moderates the relationship between gratitude and mindfulness. Third, the growth mindset played a moderated mediating role in the path of gratitude → mindfulness → happiness in both the M and M+SD conditions. Fourth, the growth mindset played a moderated mediating role in the path of gratitude → hope → happiness. Fifth, the growth mindset played a moderated mediating role in the path of gratitude → mindfulness → hope → happiness in M and M+SD conditions. Practical significance. These results will contribute to developing a model to increase happiness by using growth mindset in high school students.