bluuebunny/crossref_metadata_2025 huggingface dataset:
History of Physical Culture and Sports» as a factor of patriotic education of higher education students
Authors: Vnukova O.
Published: November 2023

In this article, the focus is on the deliberate and organized pedagogical process of instilling patriotism in future professionals of physical education and sports, with the aim of preserving and passing on national values and traditions. Specifically, this pertains to the field of physical education and sports, fostering loyalty and love for one's homeland, readiness to defend it, and the promotion of patriotic education among Ukrainian youth.

The author has developed a theoretical model for a system of patriotic education among students through the study of the history of physical education and sports. The primary goal of this model is to nurture patriotism, encompassing knowledge of the domestic history of physical education and sports within the context of global events, reverence for Ukrainian traditions in physical education and sports, pride in the achievements of Ukrainian athletes, a sense of the need to honor one's ancestors, the desire to pass on Ukrainian traditions to the younger generation, and a readiness to defend the homeland.

The possibilities of the educational component "History of Physical Education and Sports" as a means of patriotic education for students are explored. The proposed content of this component intertwines topics from both global and domestic history, providing a comprehensive understanding of events in Ukraine as an integral part of global and European processes.

The article also highlights the pedagogical conditions for the effectiveness of the system of patriotic education through the "History of Physical Education and Sports," which include the demonstration of patriotism and pedagogical skill by the instructor, the examination of the history of physical education and sports in Ukraine within the context of world history, the inheritance of the cultural heritage of the Ukrainian people, and the observance of academic integrity.
Рroblems of implementing the principles of personal-activity approach to students' physical education
Authors: Mosiychuk L.V.
Published: November 2023

The purpose of the work is to define and generalize principles of implementation of personal-activity approach to physical education in higher educational institutions in order to avoid mistakes and shortcomings in modern conditions of development of the system of higher education of Ukraine. Research methods: theoretical analysis and generalization of data of scientific and methodical literature and sources of the Internet information network on the researched problem. It is determined that a necessary condition for optimizing the physical education of students is the organization of a personal-activity approach to physical improvement. It should be based on the idea of pedagogy of cooperation, the implementation of which takes into account the principles of democratization and humanization, optimization and intensification of the training process. In accordance with these principles, it is necessary to reorient the training process from reproductive to creative with the formation of students' conscious need for physical improvement. To this end, the educational process should be primarily saturated with information from personal and social hygiene, physiology, psychology, theory and methods of physical education, forming scientifically sound views on the socio- biological essence, the role and opportunities of physical culture in human development. In this sense, physical education classes should gradually turn into lessons in knowing yourself, your body, your moral and volitional qualities, spiritual and physical capabilities.
Unveiling Cancer Burden: An Epidemiological Study in a Tertiary Cancer Center, Thailand
Authors: Vichapat Voralak , Hinon Arunrat , Boonaob Jittichai , Ukritanon Pintumas , Meeniran Banyong , Pansaksiri Somsiri
Published: November 2023

Objective: Cancer is a significant health burden. This research describes the current state of cancer epidemiology and trends in a tertiary cancer center in Thailand. Materials and Methods: Data from Saraburi Hospital electronic medical records (SBH), Thai cancer based (TCB), Pathological data, and Saraburi Provincial Public Health Office (PPHO) were merged using identification numbers and birthdates, establishing Saraburi hospital-based cancer registry. Cancers were categorized according to ICD10. Population at risk was obtained from the Thai national census department. Prevalence was calculated by dividing cancer cases by population in each district. Cause-specific incidence rates (CIRs) and mortality rates (CMRs) were estimated for cancer types and gender. Age-standardized incidence rates (ASIRs) and mortality rates (ASMRs) were calculated, weighting with 2020 Thai population data. Results: Between 2018 and 2022, 10,669 cases were identified in Saraburi province. Breast cancer was the most diagnosed cancer (17.6%), followed by colorectal (13.4%), lung cancer (7.8%), cervical cancer (5.9%), and liver cancer (5.5%). ASIR peaked at 509 (492-527) per 100,000 person-years in 2018 and decreased to 232 (220-244) per 100,000 person-years in 2022. Leading cancers for males were colorectal, lung, liver; females had breast, colorectal, cervical and lung cancer. 5-year prevalence was 1.7%. Males died mostly from lung and liver cancer (ASMR 30 and 29 per 100,000 person-years), while females died from breast cancer (ASMR 21 per 100,000 person-years). Life-time cumulative risk of death from cancer was 11%. Conclusion: This study reveals the cancer burden in Saraburi province, emphasizing the need for preventive strategies and resource allocations. The establishment of a cancer registry warrants future research.
Pengaruh Dewan Komisaris Independen, Ukuran Perusahaan Dan Profitabilitas Terhadap Pengungkapan Risiko Perusahaan Food And Beverage Di BEI
Authors: Septiana Gina , Dewi Mike Kusuma , Meirina Elsa
Published: November 2023

Pengungkapan risiko merupakan suatu jenis risiko yang dimanfaatkan perusahaan dalam menyajikan suatu informasi risiko yang datang dalam mengoperasikan aktivitas bisnis perusahaan dalam laporan keuangan satu periode. Perusahaan wajib menyajikan suatu informasi risiko serta dalam pengungkapannya secara jelas dan akurat. Penilitian ini bertujuan untuk menguji dewan komisaris independen, ukuran perusahaan dan profitabilitas terhadap pengungkapan risiko perusahaan pada sektor food and beverage di BEI. Penelitian ini menggunakan sampel pada sektor food and beverage di BEI tahun 2019-2021. Berdasarkan porpusive sampling, jumlah perusahaan food and beverage yang digunakan dalam penelitian ini adalah sebanyak 12 perusahaan. Pengujian hipotesis menggunakan regresi data panel dengan menggunakan program E Views 8.0. hasil penelitian ini menunjukkan bahwa dewan komisaris independen berpengaruh negatif signifikan terhadap pengungkapan risiko, ukuran perusahaan tidak berpengaruh terhadap pengungkapan risiko dan profitabilitas tidak berpengaruh terhadap pengungkapan risiko.
Pakistani Journalist: In the Line of Fire
Authors: Ullah Imran , Khan Rooh ul Amin , Shah Saqib
Published: November 2023

This study aims to identify the challenges posed by Pakistan's Journalists and Media workers during the war on terror. Pakistan being the strategic ally of US interests became the combined foe of terror groups. Its citizens too became the target of terrorism. Since its inception; Pakistan has been struggling to hold on to the criterion of a stable state. Its constantly deteriorating state of affairs had left deep marks on the lives of its people. The ones who had suffered and sacrificed the most for their professional obligations were the media workers. They have been held at gunpoint by both the state and non-state actors. Their steadfastness in the face of terrorism, treason charges, torture and threats had made a remarkable chapter in the history of Pakistan.
Illustration of Religious Minority Symbols in Bollywood Films: A Descriptive & Semiotic Approach
Authors: Hussain Imtiaz , Ali Shahzad , Gardezi Syed Ali Akbar
Published: November 2023

Bollywood Cinema has extended fame on the global streets and gained enormous clout through its massive audience. This current research discovers the religious symbols in thirty Hindi Films with regard to the top three minorities in India i.e. Muslims, Christians, and Sikhs. The study theoretically connected with Pierce's theory of symbol and representation theory by Stuart Hall.Qualitative descriptive semiotic analysis was applied to identify the religious symbols and reveal the underlying meaning associated with the minority characters. The symbolic analysis exposed the agenda of the Bollywood films that the symbols associated with the three minor religions like Muslim
beards, caps or veils and the concept of Jihad, Sikh turbans and Christian cross were represented in a distorted and negative way. The research is a humble opinion to provide more awareness of movie makers, directors, and producers toward minority religions before making films pertaining to religious minorities.
Legal Terminology Work For Local-Only
Minorities
Authors: Chiocchetti Elena
Published: November 2023

The paper outlines the challenges of doing legal terminology work in Italian and German to support the development of a local-only minority language (South Tyrolean German) and to foster communication with other German-speaking countries. The target groups of terminology – legal experts, language mediators and the public – have different needs and expectations that were addressed in the Information System for Legal Terminology bistro by exploiting specific terminological data categories, by seeking a compromise when drafting definitions and by implementing technical functions.
The “New Normal” Terminology
Authors: Dobrić Basaneže Katja , Bajčić Martina
Published: November 2023

This paper provides a contrastive analysis of COVID-19-related EU legislative texts with emphasis on term variants. The analysis carried out on a parallel corpus consisting of English and Croatian texts has identified multiple examples of variation of predominately multi-word terms at several levels. These include orthographic and grammatical variants, unit shifts and denominative variants creating different meanings. The findings support other contemporary studies into variation within specialized language, highlighting the importance of studying variation to gain understanding about the dynamics of domain knowledge. By focusing on variation in a parallel corpus, conclusions are drawn about the prevalence of variation in a newer EU official language, as opposed to English as the draft text of EU legislation.
Nutritional support for patients with malignant tumors
Authors: Kukosh M.Yu. , Ter-Ovanesov M.D. , Gladkov O.A. , Gaboyan A.S. , Borovkov I.M.
Published: November 2023

Nutritional support is an integral aspect of caring for patients burdened with
advanced onсological disease. Following the development of palliative medicine, it draws
a growing body of attention from medical community suggesting the expansion of practical
use indications. Nowadays rational nutritional support is defined as a combined approach
including wide implementation of supplementary nutrition along with physical activity,
drug therapy and psychological consulting.It is usually carefully designed with a help
of nutritionist, administered individually and prioritises the initial use of
physiological non-invasive forms of nutrition.Artificial nutrition also appears to have
benefit when used for patients at the end of life, but requires the critical
consideration of indications and contraindications to minimise possible impairment of
quality or even duration of life.
Ensino religioso nas escolas públicas
Authors: Schiassi Andressa Silva
Published: November 2023

Os debates acerca da laicidade de Estado no Brasil ganharam novos contornos a partir do julgamento, da Ação Direta de Inconstitucionalidade nº 4.439, que resultou na afirmação da constitucionalidade do ensino religioso confessional como disciplina facultativa nas escolas públicas de ensino fundamental. Essa decisão pode ser questionada a partir do princípio constitucional da laicidade do Estado e sob a perspectiva dos direitos fundamentais da igualdade e da liberdade de crença, tendo em vista a inviabilidade do Estado em garantir, em condições isonômicas, o ensino religioso confessional abrangente a todas as denominações religiosas. A partir dos princípios constitucionais da laicidade do Estado, igualdade, liberdade de crença e pluralismo, a pesquisa pretendeu verificar, por meio da análise de conteúdo dos votos, se a atuação do STF no julgamento da ADI nº 4.439 pode ser considerada um caso exemplar de razão pública, na perspectiva proposta por John Rawls.
Wireless handheld ultrasound for internal jugular vein assessment in pediatric patients
Authors: Greiner Barbara , Kaiser Ulrich , Maurer Katharina , Stroszczynski Christian , Jung Ernst Michael
Published: November 2023

BACKGROUND:

Rapid evolution of ultrasound technology has allowed widespread use of handheld ultrasound devices (HHUDs) for many possible applications. Along with the adult population, the use of HHUDs for Point of Care Ultrasound (POCUS) in pediatric medicine has been increasing over the last few years. However, pediatric-specific literature is still scarce on mobile vascular ultrasound.

OBJECTIVE:

To evaluate diagnostic capabilities of Vscan Air™ in comparison with high-end ultrasound for the assessment of the internal jugular vein in children and adolescents.

METHODS:

42 Internal Jugular Veins (IJVs) of 21 pediatric patients were scanned by an experienced examiner using a WLAN-supported handheld ultrasound device (Vscan Air™) and high-end cart-based ultrasound (LOGIQ E9) as reference. B-Mode and Color-coded Doppler (CCDS) were performed and compared. Image quality was assessed using a score of 0 to 5 and statistically analyzed. Results were interpreted independently by two readers in consensus.

RESULTS:

21 patients (2–17 years; mean 11,00±4,5 years; female n = 11, male n = 10) were examined. The rating score never dropped below 3 for both devices. The median score evaluation of B-Mode and CCDS for the high-end device was 5.00, of Vscan Air™ 5.00 for B-Mode and 4.00 for CCDS. A significant difference was shown between the two devices in the evaluation of CCDS.

CONCLUSIONS:

Vscan Air™ ultrasound device allows sufficient assessability of the IJV in pediatric patients, opening up new possibilities for fast and mobile POCUS of cervical veins and potential guidance of central venous catheter placement.
Green Economy Policies in the Digital Transformation of Forest Management in Indonesia
Authors: Rohmy Atikah Mardhiya , Nihayaty Arini Indah
Published: November 2023

This study examines green economy policies in relation to Indonesia’s digital transformation of forest management. It employs the normative juridical approach as well as the primary and secondary sources of legal materials. It demonstrates that the digital transformation policies of forest managements are implemented to reduce climate change and facilitate a green economy. The green economy approach underscores that sustainable development is premised upon improving human wellbeing and social equality considering environmental concerns. The instrumental theory uses a backward-looking approach and the substantive theory uses a forward-looking approach. The later adjusts to technological developments and protects interests disrupted by them. Hence, it can be used in making forestry digital transformation policies. Furthermore, the application of the legal theory of development exhibits the absolute and crucial importance of the digital transformation policies as a way of advancing forest management, community participation policies as well as transparency in environmental and forest management. They call for a holistic, all-encompassing, and interdisciplinary approaches. In view of this, this study presents novelty in the forestry-related digital transformation policies, which aim at lessening the harm to forests and ecosystems and the planet.
Open access and COUNTER usage: Hybrid OA impact on a Private Liberal Arts College
Authors: Hlasten Yuimi
Published: November 2023

The popularity of open access (OA) publications has increased in recent years. This situation leads to several pertinent questions for academic libraries: Is the rapid expansion of OA availability negatively affecting their COUNTER usage reports? And, as a consequence, is the increasing accessibility of OA publications prompting academic libraries to reconsider their subscriptions to traditional, subscription-based resources? The primary objective of this paper is to investigate the impact of hybrid OA growth on Denison University’s subscribed e-resource usage and to illuminate the potential effects of OA on academic library subscriptions.
Linking Social Cognition, Parvalbumin Interneurons, and Oxytocin in Alzheimer’s Disease: An Update
Authors: Černotová Daniela , Hrůzová Karolína , Levčík David , Svoboda Jan , Stuchlík Aleš
Published: November 2023

Finding a cure for Alzheimer’s disease (AD) has been notoriously challenging for many decades. Therefore, the current focus is mainly on prevention, timely intervention, and slowing the progression in the earliest stages. A better understanding of underlying mechanisms at the beginning of the disease could aid in early diagnosis and intervention, including alleviating symptoms or slowing down the disease progression. Changes in social cognition and progressive parvalbumin (PV) interneuron dysfunction are among the earliest observable effects of AD. Various AD rodent models mimic these early alterations, but only a narrow field of study has considered their mutual relationship. In this review, we discuss current knowledge about PV interneuron dysfunction in AD and emphasize their importance in social cognition and memory. Next, we propose oxytocin (OT) as a potent modulator of PV interneurons and as a promising treatment for managing some of the early symptoms. We further discuss the supporting evidence on its beneficial effects on AD-related pathology. Clinical trials have employed the use of OT in various neuropsychiatric diseases with promising results, but little is known about its prospective impacts on AD. On the other hand, the modulatory effects of OT in specific structures and local circuits need to be clarified in future studies. This review highlights the connection between PV interneurons and social cognition impairment in the early stages of AD and considers OT as a promising therapeutic agent for addressing these early deficits.
Changes of tRNA-Derived Fragments by Alzheimer’s Disease in Cerebrospinal Fluid and Blood Serum
Authors: Wu Wenzhe , Shen Audrey , Lee Inhan , Miranda-Morales Ernesto G. , Spratt Heidi , Pappolla Miguel A. , Fang Xiang , Bao Xiaoyong
Published: November 2023

Background:

Alzheimer’s disease (AD) is the most common type of dementia, affecting individuals over 65. AD is also a multifactorial disease, with disease mechanisms incompletely characterized, and disease-modifying therapies are marginally effective. Biomarker signatures may shed light on the diagnosis, disease mechanisms, and the development of therapeutic targets. tRNA-derived RNA fragments (tRFs), a family of recently discovered small non-coding RNAs, have been found to be significantly enhanced in human AD hippocampus tissues. However, whether tRFs change in body fluids is unknown.

Objective:

To investigate whether tRFs in body fluids are impacted by AD.

Methods:

We first used T4 polynucleotide kinase-RNA-seq, a modified next-generation sequencing technique, to identify detectable tRFs in human cerebrospinal fluid and serum samples. The detectable tRFs were then compared in these fluids from control, AD, and mild cognitive impairment patients using tRF qRT-PCR. The stability of tRFs in serum was also investigated by checking the change in tRFs in response to protein digestion or exosome lysis.

Results:

Among various tRFs, tRF5-ProAGG seemed to be impacted by AD in both cerebrospinal fluid and serum. AD-impacted serum tRF5-ProAGG showed a correlation with the AD stage. Putative targets of tRF5-ProAGG in the hippocampus were also predicted by a computational algorithm, with some targets being validated experimentally and one of them being in a negative correlation with tRF5-ProAGG even using a small size of samples.

Conclusions:

tRF5-ProAGG showed the potential as an AD biomarker and may play a role in disease progression.
Assessment and Comparison of Nonlinear Measures in Resting-State Magnetoencephalograms in Alzheimer’s Disease and Mild Cognitive Impairment
Authors: Azami Hamed , Daftarifard Elham , Humeau-Heurtier Anne , Fernandez Alberto , Abasolo Daniel , Rajji Tarek K.
Published: November 2023

Background:

Nonlinear dynamical measures, such as fractal dimension (FD), entropy, and Lempel-Ziv complexity (LZC), have been extensively investigated individually for detecting information content in magnetoencephalograms (MEGs) from patients with Alzheimer’s disease (AD).

Objective:

To compare systematically the performance of twenty conventional and recently introduced nonlinear dynamical measures in studying AD versus mild cognitive impairment (MCI) and healthy control (HC) subjects using MEG.

Methods:

We compared twenty nonlinear measures to distinguish MEG recordings from 36 AD (mean age = 74.06±6.95 years), 18 MCI (mean age = 74.89±5.57 years), and 26 HC subjects (mean age = 71.77±6.38 years) in different brain regions and also evaluated the effect of the length of MEG epochs on their performance. We also studied the correlation between these measures and cognitive performance based on the Mini-Mental State Examination (MMSE).

Results:

The results obtained by LZC, zero-crossing rate (ZCR), FD, and dispersion entropy (DispEn) measures showed significant differences among the three groups. There was no significant difference between HC and MCI. The highest Hedge’s g effect sizes for HC versus AD and MCI versus AD were respectively obtained by Higuchi’s FD (HFD) and fuzzy DispEn (FuzDispEn) in the whole brain and was most prominent in left lateral. The results obtained by HFD and FuzDispEn had a significant correlation with the MMSE scores. DispEn-based techniques, LZC, and ZCR, compared with HFD, were less sensitive to epoch length in distinguishing HC form AD.

Conclusions:

FuzDispEn was the most consistent technique to distinguish MEG dynamical patterns in AD compared with HC and MCI.
Microglial Imaging in Alzheimer’s Disease and Its Relationship to Brain Amyloid: A Human 18F-GE180 PET Study
Authors: Yang Zhengshi , Banks Sarah J. , Ritter Aaron R. , Cummings Jeffrey L. , Sreenivasan Karthik , Kinney Jefferson W. , Caldwell Jessica K. , Wong Christina G. , Miller Justin B. , Cordes Dietmar
Published: November 2023

Background: Emerging evidence suggests a potential causal role of neuroinflammation in Alzheimer’s disease (AD). Using positron emission tomography (PET) to image overexpressed 18 kDA translocator protein (TSPO) by activated microglia has gained increasing interest. The uptake of 18F-GE180 TSPO PET was observed to co-localize with inflammatory markers and have a two-stage association with amyloid PET in mice. Very few studies evaluated the diagnostic power of 18F-GE180 PET in AD population and its interpretation in human remains controversial about whether it is a marker of microglial activation or merely reflects disrupted blood-brain barrier integrity in humans. Objective: The goal of this study was to study human GE180 from the perspective of the previous animal observations. Methods: With data from twenty-four participants having 18F-GE180 and 18F-AV45 PET scans, we evaluated the group differences of 18F-GE180 uptake between participants with and without cognitive impairment. An association analysis of 18F-GE180 and 18F-AV45 was then conducted to test if the relationship in humans is consistent with the two-stage association in AD mouse model. Results: Elevated 18F-GE180 was observed in participants with cognitive impairment compared to those with normal cognition. No regions showed reduced 18F-GE180 uptake. Consistent with mouse model, a two-stage association between 18F-GE180 and 18F-AV45 was observed. Conclusions: 18F-GE180 PET imaging showed promising utility in detecting pathological alterations in a symptomatic AD population. Consistent two-stage association between 18F-GE180 and amyloid PET in human and mouse suggested that 18F-GE180 uptake in human might be considerably influenced by microglial activation.
Vacuolar Protein-Sorting Proteins Are Reduced Even Before Cognitive Decline in a Mouse Model of Alzheimer’s Disease
Authors: Shinagawa Hijiri , Ohuchi Kazuki , Goto Yuya , Hashimoto Kohei , Kijima Hideki , Maekawa Shogo , Kurita Hisaka , Inden Masatoshi
Published: November 2023

Currently, interventions from the preclinical stage are considered necessary for the treatment of Alzheimer’s disease (AD). Previous studies have reported that vacuolar protein-sorting protein (VPS), a retromer construct, is involved in the pathogenic mechanisms of AD and Parkinson’s disease. This study evaluated VPS26, VPS29, and VPS35 before and after the onset of cognitive decline in an App knock-in mouse model of AD that more closely resembles the human pathology than previous AD models. The results showed that the expression of VPS26 and VPS35 decreased before the onset of cognitive decline, suggesting the possibility of anti-amyloid-β disease-modifying treatment targeting these proteins.
CGAs-Rich Conilon Coffee Consumption Improves Cognition and Reduces Oxidative Stress in Elderly with Alzheimer’s Disease: A Pilot Study
Authors: Lopes Boschetti Júlia Carolina , Soares Karla Lírio , Carvalho Glaucimeire Rocha , Filho Abraão Carlos Verdin , Ton Alyne Mendonça Marques , Pereira Thiago de Melo Costa , Scherer Rodrigo
Published: November 2023

Background: The consumption of coffee has been associated with beneficial effects when it comes to Alzheimer’s disease (AD). However, to the best of our knowledge, there are no studies on Conilon coffee consumption in elderly people with AD. Objective: Evaluate the effects of Conilon coffee consumption in elderly with AD. Methods: The study was carried out with 9 participants who consumed a minimum of 2 cups (200 mL cup) of Conilon coffee per day for 90 days. Cognitive assessment was done before (T0) and after 90 days (T90). Blood analysis was conducted at T0 and T90, as well as the assessment of advanced oxidation protein products (AOPP) and thiobarbituric acid reactive species (TBARS). The levels of chlorogenic acids and caffeine in the coffee beverage were quantified by liquid chromatography. Results: During the treatment, the participants consumed at least 550 mg and 540 mg of CGAs and caffeine, respectively. A significant improvement in cognition between T0 and T90 was observed as per MMSE, CTP, and clock drawing tests. Furthermore, there was a significant reduction in AOPP (37%) and TBARS (60%), indicating a reduction in oxidative stress. The consumption of the coffee did not significantly alter any blood parameter, which confirms the safety of the coffee treatment during the 90 days. Conclusions: Our study demonstrated for the first time that regular consumption of coffee with high amounts of CGAs and caffeine improves cognitive functions and reduces oxidative stress, without altering blood parameters that indicate possible signs of toxicity in classical target organs.
Ferroptotic Potency of ISM1 Expression in the Drug-Induced Alzheimer’s Disease-Like Phenotype Under the Influence of Betulin
Authors: Bozkurt Ahmet Sarper , Görücü Yílmaz Şenay
Published: November 2023

Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by two main pathological mechanisms, mostly hyperphosphorylated tau and amyloid-β toxicity. Although many studies focus on these basic mechanisms, ferroptosis draws attention as an important pathway responsible for neurodegeneration in AD. There is no definitive treatment for AD but alternative phytochemicals to drugs come into prominence. Betulin is usually obtained from the birch tree. It is an abundant triterpene and has a high antioxidant capacity. Isthmin-1 (ISM1) is a secreted adipokine. Objective: In this study, we investigated the potential treatment of AD in the ferroptosis-ISM1-betulin triangle. Methods: For this, we created an AD model with okadaic acid (200 ng/kg)) in 36 Wistar albino male rats and treated with betulin (20 mg/kg/day, i.p). We evaluated ISM1 gene expression, iron accumulation, and total oxidative metabolism parameters (TAS, TOS, OSI) in hippocampal tissue. We analyzed cognitive recovery in AD with Morris Water Maze Test and general locomotor activity, explore, and anti-anxiolytic effect with Open Field Test. Results: We compared the obtained data with metabolic and genetic results. In conclusion, betulin may have a role in neuronal ferroptotic mechanisms by reducing iron accumulation by ISM1 regulation. Conclusions: Betulin may have a role in neuronal ferroptotic mechanisms by reducing iron accumulation by ISM1 regulation. Although this study suggests the corrective effect of betulin and ISM1 on cognitive gain and anxiety, it is the first study to show the total antioxidant capacity of betulin in AD.
Quantifying Variability in Motor Function in Duchenne Muscular Dystrophy: UK Centiles for the NorthStar Ambulatory Assessment, 10 m Walk Run Velocity and Rise from Floor Velocity in GC Treated Boys
Authors: Stimpson Georgia , Ridout Deborah , Wolfe Amy , Milev Evelin , O’Reilly Emer , Manzur Adnan , Sarkozy Anna , Muntoni Francesco , Cole Tim J. , Baranello Giovanni ,   on behalf of the NorthStar Network
Published: November 2023

Background

Boys with Duchenne Muscular Dystrophy (DMD) display heterogeneous motor function trajectory in clinics, which represents a significant obstacle to monitoring.

Objective:

In this paper, we present the UK centiles for the North Star Ambulatory Assessment (NSAA), the 10 m walk/run time (10MWR) and velocity (10MWRV), and the rise from floor time (RFF) and velocity (RFFV) created from a cohort of glucocorticoid treated DMD boys between the age of 5 and 16 years.

Methods:

Participants were included from the UK NorthStar registry if they had initiated steroids (primarily deflazacorts/prednisolone, intermittent/daily) and were not enrolled in an interventional trial. Assessments were included if the participant had a complete NSAA, the timed tests had been completed or the corresponding items were 0, or the participant was recorded as non-ambulant, in which case the NSAA was assumed 0.

Results:

We analysed 3987 assessments of the NSAA collected from 826 participants. Of these, 1080, 1849 and 1199 were imputed as 0 for the NSAA, RFFV and 10MWRV respectively. The 10th, 25th, 50th, 75th and 90th centiles were presented. The NSAA centiles showed a peak score of 14, 20, 26, 30 and 32 respectively, with loss of ambulation at 10.7, 12.2 and 14.3 years for the 25th, 50th and 75th centiles, respectively. The centiles showed loss of rise from floor at 8.6, 10.1 and 11.9 years and a loss of 10MWR of 0 at 8.9, 10.3 and 13.8 years for the 25th, 50th and 75th centiles, respectively. The centiles were pairwise less correlated than the raw scores, suggesting an increased ability to detect variability in the DMD cohort.

Conclusions:

The NSAA, 10MWR and RFF centiles may provide insights for clinical monitoring of DMD boys, particularly in late ambulatory participants who are uniformly declining. Future work will validate the centiles in national and international natural history cohorts.
Syntheses characterization, and photocatalytic property of an organic-inorganic compound obtained by bromine salt and the β-Mo8O26 anion
Authors: Ren Chen-Fei , Li Jia-Xuan , Li Zi-Han , Li Xin-Xin , Lu Yan-Qi , Wang Hong-Tao , Zhang Xing-Xing , Li Yuan-Yuan , Niu Yun-Yin
Published: November 2023

According to the structure/property characteristics of polyacids, the design and synthesis of new inorganic organic hybrid materials based on POMs is of great significance for the rapid and effective removal of pollutants in wastewater. In addition, many researchers have synthesized a large number of POMs-based inorganic organic hybrid compounds with organic cations as templates. Based on the above background, in this article, a new supramolecular compound named o-[C20H18N2O4][Mo8O26]0.5.H2O was obtained through hydrothermal method by reacting 1, 2-bis[4-nitrile-pyridine)-N-methylene]phenyldibromide (L1) with (NH4)6Mo7O24.4H2O. The compound was characterized by IR, PXRD, and single crystal X-ray analysis. Single crystal X-ray analysis shows that the compound consists of a [β-Mo8O26] 2–, a dicarboxylic acid chelating ligand and a water molecule. This compound exhibits good catalytic activity towards MB. The degradation rate of MB by photocatalysis of compound 1 was 75.2% . The novelty of this work lies in the synthesis of a cyano-hydrolyzed ligand and the high efficiency of MB degradation of the compound.
Sol-Gel technique, characterization and photocatalytic degradation activity of Manganese doped ZnO nanoparticles
Authors: Kistan A. , Mohan S. , Mahalakshmi S. , Jayanthi A. , Ramya A. Janaki , Karthik P. Siva
Published: November 2023

Photocatalysis using semiconductor metal oxide stands out as a highly effective and efficient method for eliminating organic pollutants from wastewater. This study aims to assess the photocatalytic capabilities of Mn doped ZnO nanocomposites in degrading methylene blue (MB) dye under ultra-violet light exposure. This study details the synthesis of ZnO photocatalysts through a straightforward one-step sol-gel method, incorporating varying levels of Mn-doping (0%, 2% & 4%). The structural and optical attributes were examined using techniques such as powder X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS) and UV-Vis diffuse reflectance spectra. X-ray diffraction analyses verified the presence of a hexagonal wurtzite crystal structure in all synthesized samples, exhibiting a high degree of crystallinity. In addition, an investigation into the impact of Mn impurities on the photocatalytic performance of ZnO catalysts was conducted in the context of methylene blue (MB) degradation. The experimental findings revealed that the Mn doped ZnO nanoparticles produced exhibited significantly superior photocatalytic performance compared to pure ZnO when used in breaking down methylene blue under UV-light exposure. This study proposes that these Mn doped ZnO could serve as a highly effective photocatalyst for treating water contaminated with certain chemically persistent synthetic organic dyes. The improved photocatalytic capabilities of ZnO nanostructures doped with Mn were ascribed to the synergistic impact of increased surface area in ZnO nanosphere and enhanced efficiency in charge separation resulting from optimized Mn doping. A potential explanation for the heightened photocatalytic performance of Mn-doped ZnO nanostructures is proposed tentatively.
Early onset neonatal thrombocytopenia is associated with severe intraventricular hemorrhage in very preterm infants: A retrospective cohort study
Authors: Bezirganoglu H. , Sari F.N. , Cetinkaya A.K. , Dizdar E.A. , Buyuktiryaki M.
Published: November 2023

BACKGROUND:

The role of platelet function in the development of intraventricular hemorrhage is still a subject of debate. In this study, we aimed to determine whether there is an association between platelet indices in the first week of life and severity of intraventricular hemorrhage in very preterm infants.

MATERIALS AND METHODS:

Preterm infants born < 30 weeks of gestation in our hospital were retrospectively evaluated. Platelet parameters, including platelet counts, mean platelet volume, platelet distribution width, and platelet mass were retrieved at two different time points: the initial value on the first day of life and the value closest to the end of the first week of life. The infants were categorized according to the findings of cranial ultrasonography as; no intraventricular hemorrhage, mild or severe intraventricular hemorrhage.

RESULTS:

Totally, 1051 infants were evaluated. The mean gestational age and birth weight for the entire cohort were 27.9±1.6 weeks and 1058±247 g, respectively. Infants in the severe intraventricular hemorrhage group had significantly lower gestational age ( p < 0.001) and birthweight ( p < 0.001) compared to other two groups. Furthermore, there were significant differences in platelet count and platelet mass between the groups at two time intervals. However, logistic regression analysis revealed that only platelet count of < 100×109/L on the first postnatal day was independently associated with the severity of intraventricular hemorrhage.

CONCLUSION:

There is an association between platelet count of < 100×109/L on the first postnatal day and severe intraventricular hemorrhage in very preterm infants.
A deep learning and radiomics based Alberta stroke program early CT score method on CTA to evaluate acute ischemic stroke
Authors: Fang Ting , Liu Naijia , Nie Shengdong , Jia Shouqiang , Ye Xiaodan
Published: November 2023

BACKGROUND:

Alberta stroke program early CT score (ASPECTS) is a semi-quantitative evaluation method used to evaluate early ischemic changes in patients with acute ischemic stroke, which can guide physicians in treatment decisions and prognostic judgments.

OBJECTIVE:

We propose a method combining deep learning and radiomics to alleviate the problem of large inter-observer variance in ASPECTS faced by physicians and assist them to improve the accuracy and comprehensiveness of the ASPECTS.

METHODS:

Our study used a brain region segmentation method based on an improved encoding-decoding network. Through the deep convolutional neural network, 10 regions defined for ASPECTS will be obtained. Then, we used Pyradiomics to extract features associated with cerebral infarction and select those significantly associated with stroke to train machine learning classifiers to determine the presence of cerebral infarction in each scored brain region.

RESULTS:

The experimental results show that the Dice coefficient for brain region segmentation reaches 0.79. Three radioactive features are selected to identify cerebral infarction in brain regions, and the 5-fold cross-validation experiment proves that these 3 features are reliable. The classifier trained based on 3 features reaches prediction performance of AUC = 0.95. Moreover, the intraclass correlation coefficient of ASPECTS between those obtained by the automated ASPECTS method and physicians is 0.86 (95% confidence interval, 0.56-0.96).

CONCLUSIONS:

This study demonstrates advantages of using a deep learning network to replace the traditional template registration for brain region segmentation, which can determine the shape and location of each brain region more precisely. In addition, a new brain region classifier based on radiomics features has potential to assist physicians in clinical stroke detection and improve the consistency of ASPECTS.
Analysis of temporary variability of the total intensity of solar radiation when assessing energy resources
Authors: Prymak O , Redko I. , Redko O. , Redko A.
Published: November 2023

The results of the analysis of temporary variability of average monthly and annual amounts of solar radiation in Ukraine for the period 2011-2020 are presented. Measurement data were compared with earlier periods and the standard period of 1961-1990. The statistical characteristics of the series of changes in solar radiation have been determined. Comparison of the characteristics of solar radiation with the normative data of SSU NBV .1.1-27-2010 was made. It has been shown that in recent years the annual amounts of direct radiation have increased by 18-23%. The total annual radiation in 2020 increased by 6% according to the period 1961-1990. The analysis of the calculated results of determining hourly values and daily sums of direct and scattered radiation obtained using empirical dependencies of engineering methods is carried out. The efficiency of using the sustainable potential of solar energy depends on the climatic characteristics of this area or region. Inconsistencies in regulations can therefore create a problem where the best places for energy production lack public interest, infrastructure and cost-effective consumption. Depending on the regional climatic conditions of Ukraine, the solar energy potential varies from 1400 MJ/m2 in the western regions to 1950 MJ/m2 in the eastern regions. An important characteristic of solar energy resources is the duration of sunshine. For the conditions of Kyiv, the average monthly value of the actual duration varies from 180 hours in March to 120 hours in November. The possible annual duration of sunshine varies accordingly from 4452 hours (2011) to 4481 hours (2020). The maximum values are observed in June (331 hours) and August (334 hours). In the southern regions of Ukraine, the actual annual duration of sunshine for Odesa conditions varies from 2387 hours (2011) to 2709 hours (2020). The criterion for the expediency of using solar energy is the annual number of clear days of more than 200. The number of clear days is not given in SSU.
Ensuring normal air quality in office premises with the existing ventilation system
Authors: Makarenko L. , Priymak О.
Published: November 2023

In the conditions of growing interest in indoor air cleaning and strengthening WHO recommendations regarding the concentration of suspended particles in the air (should not exceed 5 μg/m3), there is a need to create clear rules for placing cleaning equipment on ventilation and air conditioning systems. This applies not only to objects that are just being designed, but also to already operated objects with a functioning ventilation system. After all, it is precisely at such objects that there are limited opportunities to intervene in the work of not only engineering systems, but also the operation of the building itself during repairs. The goals of the study were to obtain data on the efficiency of air purification in a given volume with the available air exchange rate of a functioning supply-exhaust system. A separate task was to check the data declared by the manufacturer regarding the pressure drop on the built-in HERA channel filter. The most effective way to clean indoor air from pollutants is considered to be its removal from places of permanent residence of people. Using a general exchange ventilation system equipped with modern filtering equipment, you can achieve significant results in improving air quality. In this case, the ventilation system in an office building in the city center is considered, which was equipped with an additional channel filter with a MERV16 (or HEPA 11) class filter cassette. This modernization of the ventilation system in half a year of operation made it possible to reduce pollution with particles in the size range of 0.3-10 microns in the air environment of office premises by 70...76 % with an insignificant multiplicity in compliance with the norms of the minimum value of air exchange in terms of the amount of fresh air according to the sanitary norm and allowed to avoid significant capital investments for the repair of engineering networks and losses due to the impossibility of operating the building during the repair. The conclusions of the study need to be checked in office premises with an existing ventilation system when recording a gradual decrease in the concentration of pollutants in the premises during the operation of the system in order to determine the optimal multiplicity to achieve the specified air quality when using filters.
Data Interpretation in Social Research: a Guide to Standardising Research Outcomes And Outcome Evaluation
Authors: Scârneci-Domnișoru Florentina
Published: November 2023

Data interpretation, as the last stage of social research, is neglected in literature. It is described briefly, vaguely, inaccurately, being often associated with the data analysis stage or being replaced with the description of the way in which a research report must be written. The article brings arguments in favour of addressing data interpretation as a stage in itself, it shows that standardisation is needed so that the research results are easily identified, evaluated and used and it presents a universal guide, a set of rules specific to this stage, independently of the theoretical or methodological approach of the research carried out. The article also claims the introduction of results evaluation as a mandatory process for any research in which the generalisation and the practical and/or theoretical impact of the results are valued.
In the Spirit of Dr. Betty Bastien: Conceptualizing Ontological Responsibilities through the lens of Blackfoot Resilience
Authors: Lindstrom Gabrielle , Weasel Head Robert
Published: November 2023

This short reflective essay is our tribute to the legacy of Dr. Betty Bastien. We elevate Betty’s vision of Blackfoot ontological responsibilities as the foundation for the articulation of a pedagogy of Blackfoot resilience and in doing so, provide enduring reference points for Indigenous and non-Indigenous students and educators to shape university teaching and learning in ways that are consistent with Niitsitapiyssinni, Blackfoot way of life. Ultimately, this paper demonstrates how balance in teaching and learning is indeed possible.
Digital tools in testing the level of formation of professionally oriented English competence of IT students
Authors: Synekop Oksana , Koval Tamara , Matviienko Olha , Zenia Liubov
Published: November 2023

Digital tools help to determine the IT studentsʼ achievements in mastering professionally oriented English language competence (in listening, speaking, reading, writing). The involvement of digital tools in the organization of assessment activities will increase the objectivity of the obtained results and optimize the evaluating process of prospective IT specialists in foreign language classes. Therefore, the purpose of the article is the analysis of digital tools for use in testing the level of proficiency in ESP of IT students at university level. A number of methods were used in the research: analysis of scientific literature, generalization and systematization of the experience of scientists. As a result of the study, the digital tools used for creating and placing test tasks were considered. A comprehensive approach to the selection of digital tools is involved. The criteria were outlined: the possibility of a digital tool to define the IT students’ level of professionally oriented communicative competence; availability of different types of tasks; the ability to check tests both automatically and with the participation of a teacher; instant feedback; differential ability; interactivity; practicality and economy. The features of Moodle, Google Forms, Google Docs, Zoom Conference, Teams, Meet were analyzed. Digital tools help to fill tests with relevant learning material (from YouTube, TED Talks, Podcasts), create tests according to certain parameters (with the help of Chat GPT, QuestionWell / AI for Teaching). Thus, digital tools allow teachers to fill tests with relevant educational material; assess the IT students’ level of proficiency in ESP; create and fill tests with appropriate educational material; generate test tasks; simplify the assessment procedure; differentiate test tasks. In order to effectively implement digital tools, it is necessary to use a comprehensive approach to organize testing in teaching and learning process.