bluuebunny/crossref_metadata_2025 huggingface dataset:
Pyroptosis-Related LncRNA Signatures Correlate With Lung Adenocarcinoma Prognosis
Authors: Huang Hua , Shi Zijian , Li Yongwen , Zhu Guangsheng , Chen Chen , Zhang Zihe , Shi Ruifeng , Su Lianchun , Cao Peijun , Pan Zhenhua , Zhang Hongbing , Liu Minghui , Liu Hongyu , Chen Jun
Published: March 2022

Background

Pyroptosis is a new type of programmed cell death, accompanied by an intense inflammatory response. Previous studies have shown that pyroptosis can modify long-chain non-coding RNA (lncRNA), thereby affecting the occurrence and progression of tumors. However, the underlying role of pyroptosis-related lncRNA in lung adenocarcinoma (LUAD) remains to be elucidated. Therefore, the purpose of our study was to evaluate the prognostic value of pyrolysis-related lncRNA in patients with LUAD.

Methods

A total of 454 LUAD samples were downloaded from The Cancer Genome Atlas (TCGA) database. Pearson’s correlation coefficient was used to identify the pyroptosis-related lncRNAs. Unsupervised consensus clustering was used to identify the various LUAD molecular subtypes. A least absolute shrinkage and selection operator (LASSO) analysis was conducted to construct a prognostic signature.

Results

An 11-lncRNA prognostic signature out of 19 identified pyroptosis-related prognostic lncRNAs was constructed. The patients with LUAD were divided into low-risk and high-risk groups. Patients in the high-risk group had higher score values and mortality. The immune score, stromal score, and estimate score were lower in the high-risk group. The risk score was an independent predictor for OS in multivariate Cox regression analyses (HR > 1, p < 0.01). BTLA, PD-1, PD-L1, CTLA, and CD47 were lower expressed in the high-risk group.

Conclusions

Our study identified an 11-pyroptosis-related lncRNA signature. These findings could further clarify the role of pyroptosis in LUAD and guide the prognosis and individualized treatment of patients.
Heat Shock Proteins and HSF1 in Cancer
Authors: Cyran Anna M. , Zhitkovich Anatoly
Published: March 2022

Fitness of cells is dependent on protein homeostasis which is maintained by cooperative activities of protein chaperones and proteolytic machinery. Upon encountering protein-damaging conditions, cells activate the heat-shock response (HSR) which involves HSF1-mediated transcriptional upregulation of a group of chaperones – the heat shock proteins (HSPs). Cancer cells experience high levels of proteotoxic stress due to the production of mutated proteins, aneuploidy-induced excess of components of multiprotein complexes, increased translation rates, and dysregulated metabolism. To cope with this chronic state of proteotoxic stress, cancers almost invariably upregulate major components of HSR, including HSF1 and individual HSPs. Some oncogenic programs show dependence or coupling with a particular HSR factor (such as frequent coamplification of HSF1 and MYC genes). Elevated levels of HSPs and HSF1 are typically associated with drug resistance and poor clinical outcomes in various malignancies. The non-oncogene dependence (“addiction”) on protein quality controls represents a pancancer target in treating human malignancies, offering a potential to enhance efficacy of standard and targeted chemotherapy and immune checkpoint inhibitors. In cancers with specific dependencies, HSR components can serve as alternative targets to poorly druggable oncogenic drivers.
Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators—What is the Evidence so far?
Authors: Schebb Nils Helge , Kühn Hartmut , Kahnt Astrid S. , Rund Katharina M. , O’Donnell Valerie B. , Flamand Nicolas , Peters-Golden Marc , Jakobsson Per-Johan , Weylandt Karsten H. , Rohwer Nadine , Murphy Robert C. , Geisslinger Gerd , FitzGerald Garret A. , Hanson Julien , Dahlgren Claes , Alnouri Mohamad Wessam , Offermanns Stefan , Steinhilber Dieter
Published: March 2022

Formation of specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and different types of arachidonic acid 12- and 15-lipoxygenating paralogues (15-LO1, ALOX15; 15-LO2, ALOX15B; 12-LO, ALOX12). Typically, SPMs are thought to be formed via consecutive steps of oxidation of polyenoic fatty acids such as arachidonic acid, eicosapentaenoic acid or docosahexaenoic acid. One hallmark of SPM formation is that reported levels of these lipid mediators are much lower than typical pro-inflammatory mediators including the monohydroxylated fatty acid derivatives (e.g., 5-HETE), leukotrienes or certain cyclooxygenase-derived prostaglandins. Thus, reliable detection and quantification of these metabolites is challenging. This paper is aimed at critically evaluating i) the proposed biosynthetic pathways of SPM formation, ii) the current knowledge on SPM receptors and their signaling cascades and iii) the analytical methods used to quantify these pro-resolving mediators in the context of their instability and their low concentrations. Based on current literature it can be concluded that i) there is at most, a low biosynthetic capacity for SPMs in human leukocytes. ii) The identity and the signaling of the proposed G-protein-coupled SPM receptors have not been supported by studies in knock-out mice and remain to be validated. iii) In humans, SPM levels were neither related to dietary supplementation with their ω-3 polyunsaturated fatty acid precursors nor were they formed during the resolution phase of an evoked inflammatory response. iv) The reported low SPM levels cannot be reliably quantified by means of the most commonly reported methodology. Overall, these questions regarding formation, signaling and occurrence of SPMs challenge their role as endogenous mediators of the resolution of inflammation.
Effects of 6-Week Traditional and Functional Resistance Training on Arterial Stiffness and Muscular Strength in Healthy Young Men
Authors: Zuo Chongwen , Li Qing , Zhang Li , Bo Shumin
Published: March 2022

Background

The present study investigated the effects of traditional resistance training (TRT) and functional resistance training (FRT) on arterial stiffness and muscular strength in healthy young men.

Methods

This randomized controlled trial included 29 untrained healthy young men aged 18–29 years who were randomly divided into two groups, namely, TRT group (n = 15) and FRT group (n = 14). All participants underwent numerous tests, such as those for body composition, cardio-ankle vascular index, blood pressure, heart rate, and maximal strength before and after the 6-week training program. The exercise training comprised whole-body strength training exercises 3 days a week for 6 weeks. The total training volume and number of sets (4–5 sets) were kept constantly similar in each group. The TRT group completed 4–5 sets of 8–12 repetitions [70% of 1 repetition maximum (1RM)], whereas the FRT group completed 4–5 sets of 15–22 repetitions (40% 1RM).

Results

The TRT and FRT groups exhibited equally significantly increased maximal strength (within group: both p < 0.01). Furthermore, the independent t-test showed that the differences between the two groups in terms of changes in maximal strength were no significant (between group: both p > 0.05). Additionally, significant main effects of time (pre vs. post) were observed for the left and right cardio-ankle vascular indices (p < 0.05); however, no significant difference were observed between the groups. For body compositions outcome measures, no significant differences between groups were observed.

Conclusion

Six weeks of FRT and TRT exhibit no difference in terms of effects on arterial stiffness and muscular strength.
Transcriptomic and Metabolomic Analyses Reveal Key Metabolites, Pathways and Candidate Genes in Sophora davidii (Franch.) Skeels Seedlings Under Drought Stress
Authors: Zhao Xin , Huang Li-Juan , Sun Xiao-Fu , Zhao Li-Li , Wang Pu-Chang
Published: March 2022

Soil aridification and desertification are particularly prominent in China’s karst areas, severely limiting crop yields and vegetation restoration. Therefore, it is very important to identify naturally drought-tolerant plant species.Sophora davidii(Franch.) Skeels is resistant to drought and soil infertility, is deeply rooted and is an excellent plant material for soil and water conservation. We studied the transcriptomic and metabolomic changes inS. davidiiin response to drought stress (CK, control; LD, mild drought stress; MD, moderate drought stress; and SD, severe drought stress).Sophora davidiigrew normally under LD and MD stress but was inhibited under SD stress; the malondialdehyde (MDA), hydrogen peroxide (H2O2), soluble sugar, proline, chlorophyll a, chlorophyll b and carotenoid contents and ascorbate peroxidase (APX) activity significantly increased, while the superoxide dismutase (SOD), peroxidase (POD) and catalase (CAT) activities and soluble protein content significantly decreased. In the LD/CK, MD/CK and SD/CK comparison groups, there were 318, 734 and 1779 DEGs, respectively, and 100, 168 and 281 differentially accumulated metabolites, respectively. Combined analysis of the transcriptomic and metabolomic data revealed the metabolic regulation ofS. davidiiin response to drought stress. First, key candidate genes such asPRR7,PRR5,GI,ELF3,PsbQ,PsaK,INV,AMY,E2.4.1.13,E3.2.1.2,NCED,PP2C,PYL,ABF,WRKY33,P5CS,PRODH,AOC3,HPD,GPX,GST,CATandSOD1may govern the drought resistance ofS. davidii. Second, three metabolites (oxidised glutathione, abscisic acid and phenylalanine) were found to be related to drought tolerance. Third, several key candidate genes and metabolites involved in 10 metabolic pathways were identified, indicating that these metabolic pathways play an important role in the response to drought inS. davidiiand possibly other plant species.
ZEITLUPE Promotes ABA-Induced Stomatal Closure in Arabidopsis and Populus
Authors: Jurca Manuela , Sjölander Johan , Ibáñez Cristian , Matrosova Anastasia , Johansson Mikael , Kozarewa Iwanka , Takata Naoki , Bakó Laszlo , Webb Alex A. R. , Israelsson-Nordström Maria , Eriksson Maria E.
Published: March 2022

Plants balance water availability with gas exchange and photosynthesis by controlling stomatal aperture. This control is regulated in part by the circadian clock, but it remains unclear how signalling pathways of daily rhythms are integrated into stress responses. The serine/threonine protein kinase OPEN STOMATA 1 (OST1) contributes to the regulation of stomatal closureviaactivation of S-type anion channels. OST1 also mediates gene regulation in response to ABA/drought stress. We show that ZEITLUPE (ZTL), a blue light photoreceptor and clock component, also regulates ABA-induced stomatal closure inArabidopsis thaliana, establishing a link between clock and ABA-signalling pathways. ZTL sustains expression ofOST1and ABA-signalling genes. Stomatal closure in response to ABA is reduced inztlmutants, which maintain wider stomatal apertures and show higher rates of gas exchange and water loss than wild-type plants. Detached rosette leaf assays revealed a stronger water loss phenotype inztl-3,ost1-3double mutants, indicating that ZTL and OST1 contributed synergistically to the control of stomatal aperture. Experimental studies ofPopulussp., revealed that ZTL regulated the circadian clock and stomata, indicating ZTL function was similar in these trees and Arabidopsis. PSEUDO-RESPONSE REGULATOR 5 (PRR5), a known target of ZTL, affects ABA-induced responses, including stomatal regulation. Like ZTL, PRR5 interacted physically with OST1 and contributed to the integration of ABA responses with circadian clock signalling. This suggests a novel mechanism whereby the PRR proteins—which are expressed from dawn to dusk—interact with OST1 to mediate ABA-dependent plant responses to reduce water loss in time of stress.
Hunt–Vitell’s General Theory of Marketing Ethics Predicts “Attitude-Behaviour” Gap in Pro-environmental Domain
Authors: Zaikauskaitė Laura , Butler Gemma , Helmi Nurul F. S. , Robinson Charlotte L. , Treglown Luke , Tsivrikos Dimitrios , Devlin Joseph T.
Published: March 2022

The inconsistency between pro-environmental attitudes and behaviours, known as the “attitude-behaviour” gap, is exceptionally pronounced in scenarios associated with “green” choice. The current literature offers numerous explanations for the reasons behind the “attitude-behaviour” gap, however, the generalisability of these explanations is complex. In addition, the answer to the question of whether the gap occurs between attitudes and intentions, or intentions and behaviours is also unknown. In this study, we propose the moral dimension as a generalisable driver of the “attitude-behaviour” gap and investigate its effectiveness in predicting attitudes, pro-environmental intentions and subsequent behaviours. We do so by using Hunt–Vitell’s moral philosophy-based framework of ethical decision-making, which conceptualises morality as the central decision-making parameter. The results from 557 US MTurk participants revealed that the manipulation of moral dimensions, specifically deontology and teleology, impacted ethical evaluation of presented dilemmas, however, failed to translate into subsequent intentions and behaviours. This finding suggests (i) that the moral dimension has an effect in shaping attitudes toward environmental issues, and (ii) that gap occurs between attitudes and intentions rather than intentions and behaviours. Further investigation of what strengthens and/or overrides the effects of the moral dimension would help understand the reasons why moral attitudes do not always translate into subsequent intentions and behaviours in the pro-environmental domain.
Set Size of Information in Long-Term Memory Similarly Modulates Retrieval Dynamics in Young and Older Adults
Authors: Peters Jan O. , Steiger Tineke K. , Sobczak Alexandra , Bunzeck Nico
Published: March 2022

Our ability to rapidly distinguish new from already stored (old) information is important for behavior and decision making, but the underlying processes remain unclear. Here, we tested the hypothesis that contextual cues lead to a preselection of information and, therefore, faster recognition. Specifically, on the basis of previous modeling work, we hypothesized that recognition time depends on the amount of relevant content stored in long-term memory, i.e., set size, and we explored possible age-related changes of this relationship in older humans. In our paradigm, subjects learned by heart four different word lists (24, 48, 72, and 96 words) written in different colors (green, red, orange, and blue). On the day of testing, a color cue (e.g., green) indicated with a probability of 50% that a subsequent word might be from the corresponding list or from a list of new words. The old/new status of the word had to be distinguished via button press. As a main finding, we can show in a sample of n = 49 subjects, including 26 younger and 23 older humans, that response times increased linearly and logarithmically as a function of set size in both age groups. Conversely, corrected hit rates decreased as a function of set size with no statistically significant differences between both age groups. As such, our findings provide empirical evidence that contextual information can lead to a preselection of relevant information stored in long-term memory to promote efficient recognition, possibly by cyclical top-down and bottom-up processing.
Meta-Accuracy on the Internet: Initial Tests of Underlying Dimensions, Contributing Factors, and Biases
Authors: Tsankova Elena , Tair Ergyul
Published: March 2022

Meta-accuracy (correspondence between how we think others perceive us and how they really perceive us) of first impressions on the Internet has the potential to shape subsequent interactions. Aiming to enhance understanding of the underlying perceptual dimensions, the contribution of social competence, and the existence of positive/negative bias in first impressions’ meta-accuracy online, we conducted a study in a simulated asynchronous social-media-type setting. Target participants uploaded a selfie, wrote a short description of themselves, provided estimates of how warm and competent they believed others would find them based on their selfies and texts (metaperception), and completed two social competence questionnaires (general and Internet-specific). Perceiver participants assessed the warmth and competence of the selfies and texts as well (others’ perception). Meta-accuracy was measured as the absolute difference between metaperception and others’ perception. Through correlational analyses, we confirmed that meta-accuracy of first impressions on the Internet aligned with the universal dimensions of social cognition (warmth and competence), found sporadic evidence for the positive association between meta-accuracy and social competence, and showed that meta-accuracy for specific Internet expressive means varied with varying proficiency in these means. Through t-tests, we demonstrated positive meta-accuracy bias for selfies along the warmth dimension and negative bias for text along the competence dimension. Overall, our results suggest the primacy of warmth and uniqueness of the male targets-female perceivers combination for meta-accuracy on the Internet. Our findings expand knowledge about first impressions’ meta-accuracy on the Internet.
Role of Social Capital and Financial Wellbeing in Reaching Successful Entrepreneurial Financial Performance: A Moderated-Mediated Model of Financial Intelligence
Authors: Yao Lei , Meng Da
Published: March 2022

Financial wellbeing is an emerging variable in business psychology that is expected to measure overall financial status and future financial trajectories. Financial intelligence and wellbeing have been key determining factors for the financial performance of entrepreneurs. The present study aimed to examine the crucial financial determinants (financial wellbeing and financial intelligence) and social capital factors for the entrepreneurial intentions and their financial performances among the 326 entrepreneurs in China. The study's findings showed that the key financial indicators and social capital are significantly related to entrepreneurial intentions, which considerably predict the entrepreneurial financial performance. The mediating relationships also reported that entrepreneurial intentions and financial intelligence significantly mediate the relationship among social capital, financial wellbeing, and entrepreneurial financial performance. The present study has highlighted the implications for potential entrepreneurs for improving their financial performance through sustainable social capital, financial wellbeing, and financial intelligence. This study will also help the strategists in screening the individuals registering as entrepreneurs based on their financial intelligence quotient. The present study enriches the literature by offering an integrated model on financial wellbeing and entrepreneurial financial performance.
How Does Corporate Social Responsibility Affect Sustainability of Social Enterprises in Korea?
Authors: Qing Chenglin , Jin Shanyue
Published: March 2022

Social enterprises (SEs) are a new concept, integrating corporate profitability and social purposes. SEs seek to realize sustainable social values, rather than short-term profits. It is therefore important to study the factors that affect the sustainable management of SEs. Corporate social responsibility (CSR) is known to improve corporate image and performance; it can also promote the sustainable development of companies. Innovation has been described as the driving force behind corporate growth and ultimate performance. This study aims to investigate whether CSR can affect sustainability through the economic and social performance of SEs. In addition, it attempts to verify the moderating role of innovativeness in the relationship between CSR and social enterprise (SE) performance. Using survey data from 226 employees of 204 SEs in Korea, we have empirically tested this conceptual framework. The results suggest that, while CSR can improve sustainability through economic and social performance, innovativeness has no moderating effect on the relationship between CSR and SE performance. This study enriches our understanding of the important role played by CSR in driving SE sustainability. It provides new insights into the mechanisms through which SEs can achieve sustainable development. It also contributes to the literature by emphasizing the need for innovation through technical support for SEs.
Does Gender Moderate the Relationship Between Chronic Pain and Substance Use Disorder? Insights From a National Canadian Population Survey
Authors: Su Yingying , Meng Xiangfei , D'Arcy Carl
Published: March 2022

Background

Though it has been shown that men have a higher lifetime prevalence of substance use disorder and a lower prevalence of chronic pain than women, there is little research to date focusing on gender differences in the relationship between chronic pain and substance use disorder. This study examined whether gender moderates the relationship of chronic pain and substance use disorder. We also sought to examine the gender differences in the associations between specific pain types—arthritis, migraine, and back pain, and substance use disorder.

Methods

The data were drawn from the 2012 Canadian Community Health Survey-Mental Health (CCHS-MH 2012) with individuals aged 20 years and older living in the 10 Canadian provinces (N = 23,089). A two-level logistic mixed effects model was used to account for provincial differences.

Results

Our findings indicated gender moderated the association between arthritis as well as migraine, and substance use disorder. However, no moderation effect of gender on the relationship between back pain and substance use disorder was found. Specifically, the strength of the association between arthritis and substance use disorder was stronger among men (ORinteraction = 0.62, 95% CI: 0.53 to 0.73), whereas the strength of the association between migraine and substance use disorder was stronger among women (ORinteraction = 1.45, 95% CI: 1.18 to 1.79). In addition, geographical location was found to explain a small proportion (2.3%-2.4%) of the overall variance in SUD.

Conclusions

The results suggest that gender moderated the relations between arthritis as well as migraine, and substance use disorder, respectively. Treatment programs for pain and substance misuse might benefit from an approach tailored to gender differences.
Factors Associated With Experiences of Fear, Anxiety, Depression, and Changes in Sleep Pattern During the COVID-19 Pandemic Among Adults in Nigeria: A Cross-Sectional Study
Authors: Folayan Morenike Oluwatoyin , Ibigbami Olanrewaju , Brown Brandon , El Tantawi Maha , Aly Nourhan M. , Ezechi Oliver C. , Abeldaño Giuliana Florencia , Ara Eshrat , Ayanore Martin Amogre , Ellakany Passent , Gaffar Balgis , Al-Khanati Nuraldeen Maher , Idigbe Ifeoma , Jafer Mohammed , Khan Abeedha Tu-Allah , Khalid Zumama , Lawal Folake Barakat , Lusher Joanne , Nzimande Ntombifuthi P. , Popoola Bamidele Olubukola , Quadri Mir Faeq Ali , Roque Mark , Al-Tammemi Ala'a B. , Yousaf Muhammad Abrar , Virtanen Jorma I. , Zuñiga Roberto Ariel Abeldaño , Ndembi Nicaise , Nkengasong John N. , Nguyen Annie Lu
Published: March 2022

Background

Multiple facets of the pandemic can be a source of fear, depression, anxiety and can cause changes in sleep patterns. The aim of this study was to identify health profiles and the COVID-19 pandemic related factors associated with fear, depression, anxiety and changes in sleep pattern in adults in Nigeria.

Methods

The data for this analysis was extracted from a cross-sectional online survey that collected information about mental health and well-ness from a convenience sample of adults 18 years and above resident in Nigeria from July to December 2020. Study participants were asked to complete an anonymous, closed-ended online questionnaire that solicited information on sociodemographic profile, health profiles (high, moderate and low COVID-19 infection risk profile) including HIV status, COVID-19 status, and self-reported experiences of fear, anxiety, depression and changes in sleep patterns.

Results

In total, 4,439 participants with mean age of 38.3 (±11.6) years responded to the survey. Factors associated with higher odds of having COVID-19 related fear were health risk (p < 0.05); living with HIV (AOR: 3.88; 95% CI: 3.22–4.69); having COVID-19 symptoms but not tested (AOR: 1.61; 95% CI: 1.30–1.99); having a friend who tested positive to COVID-19 (AOR: 1.28; 95% CI: 1.07–1.53) and knowing someone who died from COVID-19 (AOR: 1.43; 95% CI: 1.24–1.65). The odds of feeling anxious was significantly higher for those with moderate or low health risk profile (p < 0.05); living with HIV (AOR: 1.64; 95% CI: 1.32–2.04); had a friend who tested positive for COVID-19 (AOR: 1.35; 95% CI: 1.08–1.68) or knew someone who died from COVID-19 (AOR: 1.53; 95% CI: 1.28–1.84). The odds of feeling depressed was significantly higher for those with health risk profile (p < 0.05); living with HIV (AOR: 2.49; 95% CI: 1.89–3.28); and respondents who had COVID-19 symptoms but had not taken a test (AOR: 1.41; 95% CI: 1.02–1.94). Factors associated with higher odds of having sleep pattern changes were having moderate and low health risk profiles (p < 0.05).

Conclusion

The study findings suggest that the pandemic may cause fear, anxiety, depression and changes in sleep patterns differently for people with different health profile, HIV status and COVID-19 status.
Accelerating the Development of Measles and Rubella Microarray Patches to Eliminate Measles and Rubella: Recent Progress, Remaining Challenges
Authors: Hasso-Agopsowicz Mateusz , Crowcroft Natasha , Biellik Robin , Gregory Christopher J. , Menozzi-Arnaud Marion , Amorij Jean-Pierre , Gilbert Philippe-Alexandre , Earle Kristen , Frivold Collrane , Jarrahian Courtney , Mvundura Mercy , Mistilis Jessica J. , Durrheim David N. , Giersing Birgitte
Published: March 2022

Measles and rubella microarray patches (MR-MAPs) are critical in achieving measles and rubella eradication, a goal highly unlikely to meet with current vaccines presentations. With low commercial incentive to MAP developers, limited and uncertain funding, the need for investment in a novel manufacturing facility, and remaining questions about the source of antigen, product demand, and regulatory pathway, MR-MAPs are unlikely to be prequalified by WHO and ready for use before 2033. This article describes the current progress of MR-MAPs, highlights challenges and opportunities pertinent to MR-MAPs manufacturing, regulatory approval, creating demand, and timelines to licensure. It also describes activities that are being undertaken by multiple partners to incentivise investment in and accelerate the development of MR-MAPs.
Craftivism Between Nationalism and Activism in Ukraine and Belarus
Authors: Myzelev Alla
Published: March 2022

This article outlines the history and significance of Craftivism in Eastern Europe. Using two case studies of artists it investigates the use of the craft language in Eastern Europe and its usability for activism. Do-It-Yourself culture, of which Craftivism is part, rejects the commercialism, gender norms and the conventional lifestyle in the Global North. Use of crafts as a language of political and social struggle allows to convey the message in a less confrontational but nevertheless very pertinent way. The craftivism is a successful language for the feminist political struggle in the Eastern Europe.
Organic Molecules in Interstellar Space: Latest Advances
Authors: Guélin Michel , Cernicharo Jose
Published: March 2022

Although first considered as too diluted for the formation of moleculesin-situand too harsh an environment for their survival, the interstellar medium has turned out to host a rich palette of molecular species: to date, 256 species, not counting isotopologues, have been identified. The last decade, and more particularly the last 2 years, have seen an explosion of new detections, including those of a number of complex organic species, which may be dubbed as prebiotic. Organic molecules have been discovered not just in interstellar clouds from the Solar neighbourhood, but also throughout the Milky-Way, as well as in nearby galaxies, or some of the most distant quasars. These discoveries were made possible by the completion of large sub-millimetre and radio facilities. Equipped with new generation receivers, those instruments have provided the orders of magnitude leap in sensitivity required to detect the vanishingly weak rotational lines that allowed the molecule identifications. Last 2 years, 30 prebiotic molecules have been detected in TMC-1, a dust-enshrouded gaseous cloud located at 400 light-years from the Sun in the Taurus constellation. Ten new molecular species, have been identified in the arm of a spiral galaxy seven billion light-yr distant, and 12 molecular species observed in a quasar at 11 billion light-yr. We present the latest spectral observations of this outlying quasar and discuss the implications of those detections in these 3 archetypal sources. The basic ingredients involved in the Miller-Urey experiment and related experiments (H2, H2O, CH4, NH3, CO, H2S, … ) appeared early after the formation of the first galaxies and are widespread throughout the Universe. The chemical composition of the gas in distant galaxies seems not much different from that in the nearby interstellar clouds. It presumably comprises, like for TMC-1, aromatic rings and complex organic molecules putative precursors of the RNA nucleobases, except the lines of such complex species are too weak to be detected that far.
The Epidemiological Analysis of Pseudorabies Virus and Pathogenicity of the Variant Strain in Shandong Province
Authors: Ren Qinghai , Ren Hongwei , Gu Jinyuan , Wang Jin , Jiang Luyao , Gao Song
Published: March 2022

Pseudorabies (PR) is a disease that is seriously endangering the pig industry in China. To understand the current prevalence of pseudorabies virus (PRV) in Shandong Province, China, 19,292 serum samples were collected from 16 locations in Shandong from 2018 to 2020. The gE antibody was detected by enzyme-linked immunosorbent assay. Ninety-seven suspected cases of PRV infection were collected from sick pigs vaccinated with Bartha-K61 to isolate PRV. The results showed that the average positive rate of the PRV gE antibody decreased from 38.20% in 2018 to 18.12% in 2020, but there was a high positive rate in sows. The isolation rate of PRV was 13.40% (13/97), and four strains were purified through plaque assay (named PRV-SD1, PRV-SD2, PRV-SD3, and PRV-SD4). The homology and genetic evolution of four PRV strains based on gE, gC, gI, and TK genes were analyzed and showed that these four strains shared more than 99.0% nucleotide homology with the variant PRV XJ5 strain, and they clustered in the same sub-branch with the domestic variant PRV strains, including JS-2012 and XJ5. Furthermore, the pathogenicity of the isolated variant strain was assessed by intranasal infection of 16-week-old pigs with 1 mL PRV-SD1 strain. The results of the animal experiment demonstrated that the PRV-SD1–infected pigs exhibited obvious clinical symptoms as early as 2 days post inoculation (dpi), and all infected pigs died within 1 week. The severe hyperemia of meninges and swelling of lungs and tonsils were observed. Histopathology analysis showed the obvious lymphocytes necrosis of tonsils, interstitial pneumonia, and viral encephalitis. Many positive staining cells were observed in tonsils and brains through immunohistochemistry staining assay. Viral shedding in oropharyngeal and rectal swabs were detected at 2 dpi, reached a peak at 3 dpi, and then gradually decreased. The detection of viral loads in the tissues showed that tonsils had the highest virus titer, further proving it may be the target organ of variant PRV infection. In conclusion, variant PRV strains were still highly prevalent in Shandong Province, and they had a strong pathogenicity in pigs.
Gestalt Applications to Group Work
Authors: Jude Austin  , Julius A. Austin
Published: March 2022

Gestalt group work is a dynamic and powerful approach aimed at increasing awareness and self-regulation. Group facilitators promote dialogue, curiosity, and genuine relationships between group members. The Gestalt approach asks facilitators to appreciate each group members’ perception of reality and to trust that all group members are continually in the process of becoming, remaking, and rediscovering themselves. This chapter opperationalizes the Gestalt approach so that group leaders can apply Gestalt theory to their work.
Valoraciones Éticas en Psicoterapia: Estudio con Profesionales de Salud Mental en España.
Authors: Pastor Morales Joaquín , Del Río Sánchez Carmen
Published: March 2022

Antecedentes: Estudios internacionales relacionan variables profesionales con la valoración ético-deontológica de algunas situaciones profesionales. El objetivo de este estudio es: 1) analizar las valoraciones éticas realizadas por profesionales de la salud mental del sistema sanitario público español en torno a algunas situaciones que pudieran darse en la práctica psicoterapéutica; 2) determinar situaciones controvertibles y/o de bajo consenso; y 3) estudiar la relación entre la categoría profesional y la orientación psicoterapéutica con la valoración ético-deontológica. Método: 308 participantes (209 mujeres y 99 hombres) todos ellos ejercitantes en servicios públicos de salud mental, cumplimentaron catorce ítems de la “Escala de ajuste ético y deontológico” (Pastor, 2017), así como un cuestionario de perfil sociodemográfico y profesional elaborado ad hoc. Se realizaron análisis descriptivos de los ítems y contrastes no paramétricos. Resultados: La categoría profesional y la orientación psicoterapéutica influyeron en las valoraciones éticas que se realizaron respecto a las situaciones planteadas en la escala. Se encontraron dos ítems de bajo consenso interprofesional relacionados con el derecho a la autonomía del paciente y con la terapia familiar y de pareja. Conclusiones: Se discute en torno a los aspectos éticos implicados en: 1) el debate “técnica” versus “relación”; 2) los sesgos profesionales; y 3) el mantenimiento de la relación terapéutica.
A Soft Electro-Hydraulic Pneumatic Actuator with Self-Sensing Capability toward Multi-Modal Haptic Feedback
Authors: Wang Haoyu , Cheng Xiang , Huang Pei , Yu Meng , Ma Jiaqi , Peng Shigang , Cheng Yue , Yu Yuan , Yang Weimin , Wang Pengfei , Jiao Zhiwei
Published: March 2022

Haptic feedback is appealing for achieving the realistic perception of environmental changes for human bodies in human–computer interaction fields. However, existing haptic actuators have some hurdles such as single mode, poor compatibility, or incomplete tactile information. In this study, we proposed a novel way to generate haptic feedback by designing a soft electro-hydraulic pneumatic actuator (SEHPA) with dual drive modes. The SEHPA was structured with silicone films, a silicone air chamber, flexible electrodes, and an insulating liquid dielectric for good human–machine compatibility. The SEHPA had the advantages of high output force (1.5 N at 10 kPa) and displacement (4.5 mm at 5 kPa), as well as various haptic notifications (0~400 Hz vibration). The electro-hydraulic drive method realized smooth output force changes at the millinewton level (0~40 mN) and output displacement changes at the micron level (0~800 μm), which further enriched the details of the tactile experience. In addition, the self-sensing capability of the SEHPA can be dedicated to monitoring and ensuring precise output. The SEHPAs can be potentially mounted on the fingertips to provide accurate tactile sensation once the manipulator touches an object through teleoperation. More invisible information can also be obtained by customizing various haptic notifications. The excellent response behavior and accurate tactile haptic feedback demonstrate the candidate for teleoperation fields.
The Balanced Scorecard as a Strategic Management Tool in the Textile Sector
Authors: Quesado Patrícia , Marques Salomé , Silva Rui , Ribeiro Alexandrino
Published: March 2022

This paper aims to develop a proposal for implementing the Balanced Scorecard (BSC) in a large Portuguese company that operates in the textile sector, intending to promote its subsequent implementation. Through a qualitative research approach, a case study was carried out, using interviews, which allowed clarification of the strategic guidelines of the company under study. It was found that the organization under analysis has defined the main pillars for building the BSC: the mission, values and vision. It was also found that this is an organization with an open culture, concerned with developing efforts to create and implement tools that allow clear and fluid communication of strategic objectives in all sectors that incorporate it. It was also possible to assess that the BSC is a tool known to all employees. Everyone recognized that it would be a useful tool for improving organizational performance to meet strategic objectives. However, some factors were also found that can hinder its implementation, such as the availability of time, the organizational culture and everyone’s commitment to the execution of this strategic management tool.
An Evolutionary Approach on the Framework of Circular Economy Applied to Agriculture
Authors: Batlles-delaFuente Ana , Abad-Segura Emilio , González-Zamar Mariana-Daniela , Cortés-García Francisco Joaquín
Published: March 2022

In this current and global context led by scarcity of resources, environmental degradation, global climate change, and a progressive demand for food, the circular economy (CE) represents a key economic model or framework for sustainable, restorative, and regenerative agriculture. Hence, CE applied to agriculture seeks to close the life cycle of products, services, waste, water, and energy to obtain a better use of resources and a reduction of the ecological impact. An initial review of the literature corroborates the hypothesis that the CE framework has not yet been comprehensively adapted to the field of agriculture. This research seeks to overcome this gap in relation to the performance of the circularity of agricultural production systems in support of decision-making processes. A bibliometric analysis of 1060 documents was carried to synthesize the knowledge base on this topic. The results show recent studies that identify weaknesses derived from food production, such as waste generation, biomass, water pollution, and greenhouse gas emissions. It has been identified how their analysis has developed to date and what terms allow us to visualize new approaches; consequently, it is a useful tool for researchers and sponsors who provide financial resources for the development of new lines of research.
Bioacoustic Detection of Wolves: Identifying Subspecies and Individuals by Howls
Authors: Larsen Hanne Lyngholm , Pertoldi Cino , Madsen Niels , Randi Ettore , Stronen Astrid Vik , Root-Gutteridge Holly , Pagh Sussie
Published: March 2022

Wolves (Canis lupus) are generally monitored by visual observations, camera traps, and DNA traces. In this study, we evaluated acoustic monitoring of wolf howls as a method for monitoring wolves, which may permit detection of wolves across longer distances than that permitted by camera traps. We analyzed acoustic data of wolves’ howls collected from both wild and captive ones. The analysis focused on individual and subspecies recognition. Furthermore, we aimed to determine the usefulness of acoustic monitoring in the field given the limited data for Eurasian wolves. We analyzed 170 howls from 16 individual wolves from 3 subspecies: Arctic (Canis lupus arctos), Eurasian (C. l. lupus), and Northwestern wolves (C. l. occidentalis). Variables from the fundamental frequency (f0) (lowest frequency band of a sound signal) were extracted and used in discriminant analysis, classification matrix, and pairwise post-hoc Hotelling test. The results indicated that Arctic and Eurasian wolves had subspecies identifiable calls, while Northwestern wolves did not, though this sample size was small. Identification on an individual level was successful for all subspecies. Individuals were correctly classified with 80%–100% accuracy, using discriminant function analysis. Our findings suggest acoustic monitoring could be a valuable and cost-effective tool that complements camera traps, by improving long-distance detection of wolves.
Arm Posture Changes and Influences on Hand Controller Interaction Evaluation in Virtual Reality
Authors: Lou Xiaolong , Zhao Qinping , Shi Yan , Hansen Preben
Published: March 2022

In virtual reality (VR) applications, hand-controller interaction is largely limited by the biomechanical structure of the arm and its kinematical features. Earlier research revealed that different arm postures generate distinct arm fatigue levels in mid-air operational tasks; however, how they impact interaction performance, e.g., accuracy of target grasp and manipulation, has been less investigated. To fill this gap in knowledge, we conducted an empirical experiment in which thirty participants were recruited to complete a series of target acquisition tasks in a specifically designed VR application. Results show that (1) a bent arm posture resulted in a higher interaction accuracy than a stretched arm posture; (2) a downward arm posture interacted more accurately than an upraised arm posture; since two arms are bilaterally symmetric, (3) either selected arm interacted more accurately on the corresponding side than on the opposite side; and (4) the user-preferred or dominant arm interacted more persistently than the non-dominant one, though two arms generated little difference in interaction accuracy. Implications and suggestions are discussed for designing more efficient and user-satisfying interactive spaces in VR.
Factors Affecting Cybersecurity Awareness among University Students
Authors: Alqahtani Mohammed A.
Published: March 2022

One of the essential stages in increasing cyber security is implementing an effective security awareness program. This work studies the present level of security knowledge among Imam Abdulrahman Bin Faisal University college students. A module was created to assist the students in becoming more informed. The main contribution of this work is an assessment of cybersecurity awareness among the university students based on three essential aspects: password security, browser security, and social media. Numerous questions were designed and sent to them to evaluate their awareness. The current survey received as many as 450 responses with their answers. Various statistical analyses were applied to the responses, including the validity and reliability test, feasibility test of a variable, correlation test, multicollinearity test, multiple regression, and heteroskedasticity test, carried out using SPSS. Furthermore, a multiple linear regression model and coefficient of determination, a hypothesis test, ANOVA test, and a partial test using ANOVA were also carried out. The hypothesis investigated here concerns password security, browser security, and social media. The results of partial hypothesis testing using a t-test showed that the password security variable significantly affects cybersecurity awareness (p-value = 0.0001). The regression coefficient of the password security variable in the multiple linear regression model was found to have a beta value of 0.147. In addition, the browser security variable significantly affects awareness, with a p-value = 0.0001. The regression coefficient of the password security variable had a beta value of 0.188. The social media activities variable significantly affects cybersecurity awareness (p-value = 0.0001). The regression coefficient of the social media activities variable had a beta value of 0.241. Based on the research conducted, it is concluded that knowledge of password security, browser security, and social media activities significantly influences cybersecurity awareness in students. Overall, students have realized the importance of cybersecurity awareness.
Autonomous Detection of Spodoptera frugiperda by Feeding Symptoms Directly from UAV RGB Imagery
Authors: Feng Jiedong , Sun Yaqin , Zhang Kefei , Zhao Yindi , Ren Yi , Chen Yu , Zhuang Huifu , Chen Shuo
Published: March 2022

The use of digital technologies to detect, position, and quantify pests quickly and accurately is very important in precision agriculture. Imagery acquisition using air-borne drones in combination with the deep learning technique is a new and viable solution to replace human labor such as visual interpretation, which consumes a lot of time and effort. In this study, we developed a method for automatic detecting an important maize pest—Spodoptera frugiperda—by its gnawing holes on maize leaves based on convolution neural network. We validated the split-attention mechanism in the classical network structure ResNet50, which improves the accuracy and robustness, and verified the feasibility of two kinds of gnawing holes as the identification features of Spodoptera frugiperda invasion and the degree. In order to verify the robustness of this detection method against plant morphological changes, images at the jointing stage and heading stage were used for training and testing, respectively. The performance of the models trained with the jointing stage images has been achieved the validation accuracy of ResNeSt50, ResNet50, EfficientNet, and RegNet at 98.77%, 97.59%, 97.89%, and 98.07%, with a heading stage test accuracy of 89.39%, 81.88%, 86.21%, and 84.21%.
Nano-Scale Mechanical Properties of the Articular Cartilage Zones in a Mouse Model of Post-Traumatic Osteoarthritis
Authors: Fleischhauer Lutz , Muschter Dominique , Farkas Zsuzsanna , Grässel Susanne , Aszodi Attila , Clausen-Schaumann Hauke , Alberton Paolo
Published: March 2022

Destabilization of the medial meniscus (DMM) surgery in mice is used to elucidate the mechanism of post-traumatic osteoarthritis (PT-OA). The study of cartilage biomechanics in PT-OA is important for understanding the pathophysiology of the condition. We used indentation-type atomic force microscopy (IT-AFM) to assess the nanostiffness of the interterritorial matrix of articular cartilage (AC) zones in the medial and the lateral tibia plateau (MTP and LTP) on native tissue sections 2 and 8 weeks after DMM or Sham surgery. At 2 weeks, pronounced stiffening of the DMM AC was observed compared to Sham, with the most marked changes occurring in the superficial zone and affecting the proteoglycan moiety rather than the collagen network. The LTP cartilage was obviously stiffer than the MTP in DMM, but not in Sham. At 8 weeks, only modest differences in nanostiffness were observed between DMM and Sham. The difference in stiffness between MTP and LTP was reduced, and the proteoglycan and collagen phases changed in a more similar manner. Interestingly, the deep zone was softer in the DMM compared to the Sham. Sham AC showed an increase in stiffness between 2 and 8 weeks, a trend that was counteracted in the DMM group. Collectively, our study demonstrates that nano-scale IT-AFM is a sensitive tool to monitor biomechanical changes during the course of PT-OA.