bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table S1 from Germline USP36 Mutation Confers Resistance to EGFR-TKIs by Upregulating MLLT3 Expression in Patients with Non–Small Cell Lung Cancer
Authors: Guan Shaoxing , Chen Xi , Wei Yuru , Wang Fei , Xie Wen , Chen Youhao , Liang Heng , Zhu Xia , Yang Yunpeng , Fang Wenfeng , Huang Yan , Zhao Hongyun , Zhang Xiaoxu , Liu Shu , Zhuang Wei , Huang Min , Wang Xueding , Zhang Li
Published: April 2024

Table S1. Patients’ characteristics.
Supplementary Table S4 from Clinical and Genomic Predictors of Adverse Events in Newly Diagnosed Glioblastoma
Authors: Lim-Fat Mary Jane , Iorgulescu J. Bryan , Rahman Rifaquat , Bhave Varun , Muzikansky Alona , Woodward Eleanor , Whorral Sydney , Allen Marie , Touat Mehdi , Li Xiaomei , Xy Gongwen , Patel Jay , Gerstner Elizabeth R. , Kalpathy-Cramer Jayashree , Youssef Gilbert , Chukwueke Ugonma , McFaline-Figueroa J. Ricardo , Nayak Lakshmi , Lee Eudocia Q. , Reardon David A. , Beroukhim Rameen , Huang Raymond Y. , Bi Wenya Linda , Ligon Keith L. , Wen Patrick Y.
Published: April 2024

Supplemental Table 4: Multivariable analysis of molecular alterations associated with seizure at presentation showing significant genes at a false discovery rate (FDR) <0.2. Multivariable models included preoperative tumor volume, tumor location, and age at diagnosis. Abbreviations: GoF, gain of function; LoF, loss of function.
Supplementary Table S5 from Dual-Hit Strategy for Therapeutic Targeting of Pancreatic Cancer in Patient-Derived Xenograft Tumors
Authors: Roy Chaudhuri Tista , Lin Qingxiang , Stachowiak Ewa K. , Rosario Spencer R. , Spernyak Joseph A. , Ma Wen Wee , Stachowiak Michal K. , Greene Michelle K. , Quinn Gerard P. , McDade Simon S. , Clynes Martin , Scott Christopher J. , Straubinger Robert M.
Published: April 2024

Supplementary Table S5. Gene set enrichment analysis of genes differentially expressed in sHHi treated PDX #18269 based on GO annotations
Supplementary Table S1 from Dual-Hit Strategy for Therapeutic Targeting of Pancreatic Cancer in Patient-Derived Xenograft Tumors
Authors: Roy Chaudhuri Tista , Lin Qingxiang , Stachowiak Ewa K. , Rosario Spencer R. , Spernyak Joseph A. , Ma Wen Wee , Stachowiak Michal K. , Greene Michelle K. , Quinn Gerard P. , McDade Simon S. , Clynes Martin , Scott Christopher J. , Straubinger Robert M.
Published: April 2024

Supplementary Table S1. Antibodies and concentrations
Supplementary Methods 1 from Dual-Hit Strategy for Therapeutic Targeting of Pancreatic Cancer in Patient-Derived Xenograft Tumors
Authors: Roy Chaudhuri Tista , Lin Qingxiang , Stachowiak Ewa K. , Rosario Spencer R. , Spernyak Joseph A. , Ma Wen Wee , Stachowiak Michal K. , Greene Michelle K. , Quinn Gerard P. , McDade Simon S. , Clynes Martin , Scott Christopher J. , Straubinger Robert M.
Published: April 2024

Supplementary Methods
Supplementary Figure S8 from Dual-Hit Strategy for Therapeutic Targeting of Pancreatic Cancer in Patient-Derived Xenograft Tumors
Authors: Roy Chaudhuri Tista , Lin Qingxiang , Stachowiak Ewa K. , Rosario Spencer R. , Spernyak Joseph A. , Ma Wen Wee , Stachowiak Michal K. , Greene Michelle K. , Quinn Gerard P. , McDade Simon S. , Clynes Martin , Scott Christopher J. , Straubinger Robert M.
Published: April 2024

Supplementary Figure S8. Correlation of FGFR1 expression with EMT marker expression in PDAC patient tumors
Supplementary Table S1 from FDA Approval Summary: Ivosidenib in Combination with Azacitidine for Treatment of Patients with Newly Diagnosed Acute Myeloid Leukemia with an IDH1 Mutation
Authors: Woods Ashley , Norsworthy Kelly J. , Wang Xin , Vallejo Jonathon , Chiu Yuen Chow Edwin , Li Ruo-Jing , Sun Jielin , Charlab Rosane , Jiang Xiling , Pazdur Richard , Theoret Marc R. , de Claro R. Angelo
Published: April 2024

Preferred Terms included in grouped terms
Supplementary Figure S2 from Dual-Hit Strategy for Therapeutic Targeting of Pancreatic Cancer in Patient-Derived Xenograft Tumors
Authors: Roy Chaudhuri Tista , Lin Qingxiang , Stachowiak Ewa K. , Rosario Spencer R. , Spernyak Joseph A. , Ma Wen Wee , Stachowiak Michal K. , Greene Michelle K. , Quinn Gerard P. , McDade Simon S. , Clynes Martin , Scott Christopher J. , Straubinger Robert M.
Published: April 2024

Supplementary Figure S2. SHHi-treatment decreases tumor collagen and enhances SSL-DiI permeability and deposition
Supplementary Figure S1 from Dual-Hit Strategy for Therapeutic Targeting of Pancreatic Cancer in Patient-Derived Xenograft Tumors
Authors: Roy Chaudhuri Tista , Lin Qingxiang , Stachowiak Ewa K. , Rosario Spencer R. , Spernyak Joseph A. , Ma Wen Wee , Stachowiak Michal K. , Greene Michelle K. , Quinn Gerard P. , McDade Simon S. , Clynes Martin , Scott Christopher J. , Straubinger Robert M.
Published: April 2024

Supplementary Figure S1. Histological and growth characteristics of PDAC PDXs
Supplementary Table 3 from Phase II Study of Eribulin plus Pembrolizumab in Metastatic Soft-tissue Sarcomas: Clinical Outcomes and Biological Correlates
Authors: Haddox Candace L. , Nathenson Michael J. , Mazzola Emanuele , Lin Jia-Ren , Baginska Joanna , Nau Allison , Weirather Jason L. , Choy Edwin , Marino-Enriquez Adrian , Morgan Jeffrey A. , Cote Gregory M. , Merriam Priscilla , Wagner Andrew J. , Sorger Peter K. , Santagata Sandro , George Suzanne
Published: April 2024

Supplementary Table 3. Soft tissue cancer statistics with respect to incidence, age, race/ethnicity, and geographical distribution in the United States.
Supplementary Table 2 from Phase II Study of Eribulin plus Pembrolizumab in Metastatic Soft-tissue Sarcomas: Clinical Outcomes and Biological Correlates
Authors: Haddox Candace L. , Nathenson Michael J. , Mazzola Emanuele , Lin Jia-Ren , Baginska Joanna , Nau Allison , Weirather Jason L. , Choy Edwin , Marino-Enriquez Adrian , Morgan Jeffrey A. , Cote Gregory M. , Merriam Priscilla , Wagner Andrew J. , Sorger Peter K. , Santagata Sandro , George Suzanne
Published: April 2024

Supplementary Table 2. Antibodies and dilutions used in Cyclic Immunofluorescence (CyCIF) with vendor, catalogue number, and dilution used for each marker.
Supplementary Table 1 from Phase II Study of Eribulin plus Pembrolizumab in Metastatic Soft-tissue Sarcomas: Clinical Outcomes and Biological Correlates
Authors: Haddox Candace L. , Nathenson Michael J. , Mazzola Emanuele , Lin Jia-Ren , Baginska Joanna , Nau Allison , Weirather Jason L. , Choy Edwin , Marino-Enriquez Adrian , Morgan Jeffrey A. , Cote Gregory M. , Merriam Priscilla , Wagner Andrew J. , Sorger Peter K. , Santagata Sandro , George Suzanne
Published: April 2024

Supplementary Table 1. Antibodies and dilutions used in cytometry by time of flight (CyTOF) on peripheral blood mononuclear cells (PBMCs). Standard Biotools is the vendor for all antibodies listed.
Data from Combined Vorinostat and Chloroquine Inhibit Sodium–Iodide Symporter Endocytosis and Enhance Radionuclide Uptake In Vivo
Authors: Read Martin L. , Brookes Katie , Zha Ling , Manivannan Selvambigai , Kim Jana , Kocbiyik Merve , Fletcher Alice , Gorvin Caroline M. , Firth George , Fruhwirth Gilbert O. , Nicola Juan P. , Jhiang Sissy , Ringel Matthew D. , Campbell Moray J. , Sunassee Kavitha , Blower Philip J. , Boelaert Kristien , Nieto Hannah R. , Smith Vicki E. , McCabe Christopher J.
Published: April 2024

AbstractPurpose:
Patients with aggressive thyroid cancer are frequently failed by the central therapy of ablative radioiodide (RAI) uptake, due to reduced plasma membrane (PM) localization of the sodium/iodide symporter (NIS). We aimed to understand how NIS is endocytosed away from the PM of human thyroid cancer cells, and whether this was druggable in vivo.
Experimental Design:
Informed by analysis of endocytic gene expression in patients with aggressive thyroid cancer, we used mutagenesis, NanoBiT interaction assays, cell surface biotinylation assays, RAI uptake, and NanoBRET to understand the mechanisms of NIS endocytosis in transformed cell lines and patient-derived human primary thyroid cells. Systemic drug responses were monitored via 99mTc pertechnetate gamma counting and gene expression in BALB/c mice.
Results:
We identified an acidic dipeptide within the NIS C-terminus that mediates binding to the σ2 subunit of the Adaptor Protein 2 (AP2) heterotetramer. We discovered that the FDA-approved drug chloroquine (CQ) modulates NIS accumulation at the PM in a functional manner that is AP2 dependent. In vivo, CQ treatment of BALB/c mice significantly enhanced thyroidal uptake of 99mTc pertechnetate in combination with the histone deacetylase (HDAC) inhibitor vorinostat/SAHA, accompanied by increased thyroidal NIS mRNA. Bioinformatic analyses validated the clinical relevance of AP2 genes with disease-free survival in RAI-treated DTC, enabling construction of an AP2 gene–related risk score classifier for predicting recurrence.
Conclusions:
NIS internalization is specifically druggable in vivo. Our data, therefore, provide new translatable potential for improving RAI therapy using FDA-approved drugs in patients with aggressive thyroid cancer.

See related commentary by Lechner and Brent, p. 1220
Data from Development of a [89Zr]Zr-labeled Human Antibody using a Novel Phage-displayed Human scFv Library
Authors: Singh Abhay K. , Lewis Calvin D. , Boas Cristian A.W.V. , Diebolder Philipp , Jethva Prashant N. , Rhee Aaron , Song Jong Hee , Goo Young Ah , Li Shunqian , Nickels Michael L. , Liu Yongjian , Rogers Buck E. , Kapoor Vaishali , Hallahan Dennis E.
Published: April 2024

AbstractPurpose:
Tax-interacting protein 1 (TIP1) is a cancer-specific radiation-inducible cell surface antigen that plays a role in cancer progression and resistance to therapy. This study aimed to develop a novel anti-TIP1 human antibody for noninvasive PET imaging in patients with cancer.
Experimental Design:
A phage-displayed single-chain variable fragment (scFv) library was created from healthy donors’ blood. High-affinity anti-TIP1 scFvs were selected from the library and engineered to human IgG1. Purified Abs were characterized by size exclusion chromatography high-performance liquid chromatography (SEC-HPLC), native mass spectrometry (native MS), ELISA, BIAcore, and flow cytometry. The labeling of positron emitter [89Zr]Zr to the lead Ab, L111, was optimized using deferoxamine (DFO) chelator. The stability of [89Zr]Zr-DFO-L111 was assessed in human serum. Small animal PET studies were performed in lung cancer tumor models (A549 and H460).
Results:
We obtained 95% pure L111 by SEC-HPLC. Native MS confirmed the intact mass and glycosylation pattern of L111. Conjugation of three molar equivalents of DFO led to the optimal DFO-to-L111 ratio of 1.05. Radiochemical purity of 99.9% and specific activity of 0.37 MBq/μg was obtained for [89Zr]Zr-DFO-L111. [89Zr]Zr-DFO-L111 was stable in human serum over 7 days. The immunoreactive fraction in cell surface binding studies was 96%. In PET, preinjection with 4 mg/kg cold L111 before [89Zr]Zr-DFO-L111 (7.4 MBq; 20 μg) significantly (P < 0.01) enhanced the tumor-to-muscle standard uptake values (SUVmax) ratios on day 5 compared with day 2 postinjection.
Conclusions:
L111 Ab targets lung cancer cells in vitro and in vivo. [89Zr]Zr-DFO-L111 is a human antibody that will be evaluated in the first in-human study of safety and PET imaging.
Data from Sensitive MRD Detection from Lymphatic Fluid after Surgery in HPV-Associated Oropharyngeal Cancer
Authors: Earland Noah , Semenkovich Nicholas P. , Ramirez Ricardo J. , Gerndt Sophie P. , Harris Peter K. , Gu Zhuosheng , Hearn Andrew I. , Inkman Matthew , Szymanski Jeffrey J. , Whitfield Damion , Wahle Benjamin M. , Xu Zhongping , Chen Kevin , Alahi Irfan , Ni Gabris , Chen Andrew , Winckler Wendy , Zhang Jin , Chaudhuri Aadel A. , Zevallos Jose P.
Published: April 2024

AbstractPurpose:
Our goal was to demonstrate that lymphatic drainage fluid (lymph) has improved sensitivity in quantifying postoperative minimal residual disease (MRD) in locally advanced human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) compared with plasma, and leverage this novel biofluid for patient risk stratification.
Experimental Design:
We prospectively collected lymph samples from neck drains of 106 patients with HPV (+) OPSCC, along with 67 matched plasma samples, 24 hours after surgery. PCR and next-generation sequencing were used to quantify cancer-associated cell-free HPV (cf-HPV) and tumor-informed variants in lymph and plasma. Next, lymph cf-HPV and variants were compared with TNM stage, extranodal extension (ENE), and composite definitions of high-risk pathology. We then created a machine learning model, informed by lymph MRD and clinicopathologic features, to compare with progression-free survival (PFS).
Results:
Postoperative lymph was enriched with cf-HPV compared with plasma (P < 0.0001) and correlated with pN2 stage (P = 0.003), ENE (P < 0.0001), and trial-defined pathologic risk criteria (mean AUC = 0.78). In addition, the lymph mutation number and variant allele frequency were higher in pN2 ENE (+) necks than in pN1 ENE (+) (P = 0.03, P = 0.02) or pN0-N1 ENE (−) (P = 0.04, P = 0.03, respectively). The lymph MRD-informed risk model demonstrated inferior PFS in high-risk patients (AUC = 0.96, P < 0.0001).
Conclusions:
Variant and cf-HPV quantification, performed in 24-hour postoperative lymph samples, reflects single- and multifeature high-risk pathologic criteria. Incorporating lymphatic MRD and clinicopathologic feature analysis can stratify PFS early after surgery in patients with HPV (+) head and neck cancer.

See related commentary by Shannon and Iyer, p. 1223
Data from Clinical and Genomic Predictors of Adverse Events in Newly Diagnosed Glioblastoma
Authors: Lim-Fat Mary Jane , Iorgulescu J. Bryan , Rahman Rifaquat , Bhave Varun , Muzikansky Alona , Woodward Eleanor , Whorral Sydney , Allen Marie , Touat Mehdi , Li Xiaomei , Xy Gongwen , Patel Jay , Gerstner Elizabeth R. , Kalpathy-Cramer Jayashree , Youssef Gilbert , Chukwueke Ugonma , McFaline-Figueroa J. Ricardo , Nayak Lakshmi , Lee Eudocia Q. , Reardon David A. , Beroukhim Rameen , Huang Raymond Y. , Bi Wenya Linda , Ligon Keith L. , Wen Patrick Y.
Published: April 2024

AbstractPurpose:
Adverse clinical events cause significant morbidity in patients with GBM (GBM). We examined whether genomic alterations were associated with AE (AE) in patients with GBM.
Experimental Design:
We identified adults with histologically confirmed IDH-wild-type GBM with targeted next-generation sequencing (OncoPanel) at Dana Farber Cancer Institute from 2013 to 2019. Seizure at presentation, lymphopenia, thromboembolic events, pseudoprogression, and early progression (within 6 months of diagnosis) were identified as AE. The biologic function of genetic variants was categorized as loss-of-function (LoF), no change in function, or gain-of-function (GoF) using a somatic tumor mutation knowledge base (OncoKB) and consensus protein function predictions. Associations between functional genomic alterations and AE were examined using univariate logistic regressions and multivariable regressions adjusted for additional clinical predictors.
Results:
Our study included 470 patients diagnosed with GBM who met the study criteria. We focused on 105 genes that had sequencing data available for ≥ 90% of the patients and were altered in ≥10% of the cohort. Following false-discovery rate (FDR) correction and multivariable adjustment, the TP53, RB1, IGF1R, and DIS3 LoF alterations were associated with lower odds of seizures, while EGFR, SMARCA4, GNA11, BRD4, and TCF3 GoF and SETD2 LoF alterations were associated with higher odds of seizures. For all other AE of interest, no significant associations were found with genomic alterations following FDR correction.
Conclusions:
Genomic biomarkers based on functional variant analysis of a routine clinical panel may help identify AE in GBM, particularly seizures. Identifying these risk factors could improve the management of patients through better supportive care and consideration of prophylactic therapies.
Impacto del docente innovador sobre el aprendizaje utilizando las TICs en secundaria
Authors: Alvarez Laverde Jhon Jairo , Monroy Iñiguez Felipe Jesús , Ramírez García Susana
Published: April 2024

Este artículo presenta hallazgos derivados de la investigación magisterial denominada “Impacto del docente innovador sobre el aprendizaje utilizando las TICs en secundaria”. El estudio está enmarcado dentro de la metodología cualitativa bajo el paradigma fenomenológico. Los instrumentos que se emplearon fueron la entrevista, la observación y la revisión de documentos. Los resultados indican que los docentes utilizan las herramientas TIC disponibles intentando con ello innovar y mejorar los procesos formativos. Además se constató que los docentes no utilizan las teorías de aprendizaje para mejorar los procesos de enseñanza-aprendizaje. Se pudo evidenciar algunas características del docente innovador en su quehacer educativo. La relevancia de este estudio para la educación es que se marcó el inicio de una investigación que puede ser ampliada para indagar el impacto que tienen los docentes sobre la calidad de la educación impartida en las instituciones del sector.
Las Políticas Educativas Rurales en Colombia 1990- 2018
Authors: Bohórquez Forero Juan Pablo
Published: April 2024

El presente artículo de reflexión tiene un doble objetivo, en primer lugar, se busca hacer un recorrido por las principales políticas educativas del sector rural en el periodo comprendido entre 1990 a 2018 y, en segunda medida, se pretende analizar cuáles han sido las principales tendencias de dichas políticas. Metodológicamente se utilizó el análisis documental para la revisión de las políticas públicas; los datos fueron transcritos y categorizados lo que facilitó el análisis de contenido. El artículo caracteriza dos tendencias fundamentales: políticas de cobertura y políticas economicistas. Las primeras buscan flexibilizar el servicio educativo para llegar a las comunidades más vulnerables y apartadas del país; mientras que la segunda tendencia busca activar el sector rural para ser más competitivo económicamente. Se concluye que las políticas educativas rurales tienen una idea parcializada del campo colombiano y no han representado cambios significativos
Estratégias projetuais para a produção de moradias flexíveis e adaptáveis
Authors: Freitas Rodrigo , Morado Nascimento Denise
Published: April 2024

Este artículo presenta resultados de la investigación del máster “autor”. Las obras expresan una producción diferente al estándar, analizadas considerando estrategias de diseño para producción de viviendas que permiten transformaciones espaciales y adaptaciones de uso en el tiempo, así como los conceptos que las guían. Los casos estudiados se destacan por la reestructuración de la participación de agentes que intervienen en el proceso de producción de la edificación, resultando espacios menos inducidos por determinaciones económicas y más coherentes con el desarrollo de espacios urbanos democráticos y sostenibles. En el horizonte, se pretende orientar la reflexión sobre las prácticas y estrategias proyectuales de los arquitectos contemporáneos.
A infraestrutura verde como expressão da desigualdade socioespacial: o caso dos loteamentos de acesso controlado e das favelas em Bauru/SP
Authors: Veríssimo Ryller Chrystian de Andrade , Alves Silvana Aparecida , Retto Junior Adalberto da Silva , Daibem Ana Maria Lombardi
Published: April 2024

The research investigates at once the green and gray infrastructure, aiming to compare and analyze the inequalities between the controlled access allotments: Pq. Residencial Paineiras and Jardim Shangri-Lá; and the favelas: Ferradura Mirim and Jardim Nicéia, in Bauru/SP. The aim is to study the green infrastructure as an expression of sociospatial inequalities present in these neighborhoods and that encompass an intricate framework of problems that span temporal and territorial scales, perpetuated in urban planning. Thus, through the analyses and the construction of cartographies of these neighborhoods, sought to evaluate the current panorama of the city and the challenges for future scenarios, aiming at a transversality between the urban planner, society and public policies, in the mitigation of social, environmental and urbanistic inequalities.
Prêmio Rogelio Salmona: uma visão da arquitetura da América Latina?
Authors: Cavalcanti Guilherme , Bonates Mariana
Published: April 2024

In 2014 the Latin American Rogelio Salmona Award was launched in response to an international valuation system that used to marginalize Latin America architecture in competitions. Therefore, the award was an attempt to consider the Latin American territory by its own criteria with a selection of 60 buildings. Those buildings, however, also reproduced a relationship of domination between the center and the periphery. Considering the three editions promoted by the award, this paper discusses the center-periphery relationships into the region. Some buildings were analyzed by categories such as place, scale, use, and materials. As a result, one could perceive the sliding boundaries between the center and periphery, and also the significant role played by some buildings in the periphery.
Efeitos da cobertura de solo e poluição do ar no risco de nascimentos prematuros
Authors: Moreira Tiana C. L. , Polizel Jefferson L. , Réquia Weeberb J. , Saldiva Paulo Hilario Nascimento , Silva Filho Demostenes F. da , Saldiva Silvia Regina Dias Medici , Mauad Thais
Published: April 2024

OBJECTIVE: To evaluate the association between gestational age and green areas, urban built areas, and the concentration of particulate matter 2.5 (PM2.5) in the city of São Paulo, analyzing the irregular distribution of these areas and pollution levels above the recommended level. METHODS: The study population consisted of a cohort of live births from 2012, and data from the Live Birth Information System (Sinasc) of the city of São Paulo were used. Using satellite images and supervised classification, the distribution and quantity of green areas and built areas in the city of São Paulo was obtained, as well as the concentrations of PM2.5. Logistic regressions were used to obtain possible associations. RESULTS: The results of the study show that a lower percentage of green areas is significantly associated with a higher chance of preterm births. A higher building density was positively associated with the odds ratio for preterm birth. We did not find any significant associations between air pollution (PM2.5) and preterm births. CONCLUSIONS: The results of this study show that greener areas are less associated with preterm births when compared with less green areas.
New Euplocania species (Psocodea: Ptiloneuridae) from Colombia, Ecuador and Nicaragua, amendments and addition to species groups
Authors: GONZÁLEZ-OBANDO RANULFO , GARCÍA-ALDRETE ALFONSO , CARREJO-GIRONZA NANCY , VINASCO-MONDRAGÓN ANDRÉS FELIPE
Published: April 2024

Three new species of Euplocania (Ptiloneuridae) are described, illustrated, and assigned to two species groups. These new species are E. coyolarensis n. sp., E. erwini n. sp. and E. siona n. sp. The species group danubiana is re-diagnosed, by establishing that the male hypandrium is of one sclerite, rather than three, as it had been previously diagnosed. Among the amendments proposed, the species group zelayensis now includes only E. zelayensis García Aldrete and exclude E. reyesi García Aldrete, González Obando & Carrejo and E. guentherbuchi González Obando, García Aldrete & Carrejo, as had been previously established. Species group guentherbuchi is diagnosed and includes E. guentherbuchi and E. nasa González-Obando, García Aldrete & Carrejo. Euplocania coyolarensis n. sp., is described from Nicaragua, and includes as part of the species group danubiana. Species group D is also re-diagnosed and named group erwini, including the other two species described here.
Description of two new species of mole crickets from the genus Gryllotalpa (Orthoptera: Gryllotalpidae) in Cameroon, with a key to the Afrotropical parva group species
Authors: SIMEU-NOUTCHOM ALAIN , KEKEUNOU SEVILOR , WANDJI ALAIN CHRISTEL , NZIKE MARCELLE MBADJOUN , NKWALA ALFIERY LAUREL DJOMNANG
Published: April 2024

A survey was conducted in two successive years, from March 2016 to March 2018, in three regions of Cameroon, during which two new species were collected in two regions and described. These two species, Gryllotalpa cameroonensis sp. nov. and Gryllotalpa tamessei sp. nov. were caught using the pitfall method in forests, agroforests, herbaceous fallows, and crop fields. From an ecological point of view, both new species were accidental in all vegetation types except crop fields, in which Gryllotalpa cameroonensis sp. nov. was accessory. Their habitat characteristics might require sandy soil for G. cameroonensis sp. nov. and silty soil for G. tamessei sp. nov., as well as low soil moisture and acid soil for both new species. The descriptions were followed by a revised key to the Afrotropical parva group species. This paper helps update the data on mole cricket biodiversity in Africa.
The Utilization of Laparoscopic Ventral Hernia Repair (LVHR) in Incarcerated and Strangulated Cases: A National Trend in Outcomes
Authors: Holland Alexis M. , Lorenz William R. , Mead Brittany S. , Scarola Gregory T. , Augenstein Vedra A. , Kercher Kent W. , Heniford B. Todd
Published: April 2024

Introduction

Early after its adoption, minimally invasive surgery had limited usefulness in emergent cases. However, with improvements in equipment, techniques, and skills, laparoscopy in complex and emergency operations expanded substantially. This study aimed to examine the trend of laparoscopy in incarcerated or strangulated ventral hernia repair (VHR) over time.

Methods

The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database was queried for laparoscopic repair of incarcerated and strangulated hernias (LIS-VHR) and compared over 2 time periods, 2014-2016 and 2017-2019.

Results

The utilization of laparoscopy in all incarcerated or strangulated VHR increased over time (2014-2016: 39.9% (n = 14 075) vs 2017-2019: 46.3% (n = 18 369), P < .001). Though likely not clinically significant, demographics and comorbidities statistically differed between groups (female: 51.7% vs 50.0%, P = .003; age 54.5 ± 13.7 vs 55.4 ± 13.8 years, P < .001; BMI 34.9 ± 8.0 vs 34.6 ± 7.8 kg/m2, P < .001). Patients from 2017 to 2019 were less comorbid (18.9% vs 16.8% smokers, P < .001; 18.2% vs 17.3% diabetic, P = .036; 4.6% vs 4.1% COPD, P = .021) but had higher ASA classification (III: 43.3% vs 45.7%; IV: 2.5% vs 2.7%, P < .001). Hernia types (primary, incisional, recurrent) were similar in each group. Operative time (89.7 ± 59.3 vs 97.4 ± 63.4 min, P < .001) became longer but length-of-stay (1.4 ± 3.3 vs 1.1 ± 2.6 days, P < .001) decreased. There was no statistical difference in surgical complications, medical complications, reoperation, or readmission rates between periods.

Conclusion

Laparoscopic VHR has become a routine method for treating incarcerated and strangulated hernias, and its utilization continues to increase over time. Clinical outcomes have remained the same while hospital stays have decreased.
From Blunt Cardiac Injury to Heart Transplant Following Motorcycle Collision
Authors: Van Horn Alexandra L. , Burgess Jessica R.
Published: April 2024

Traumatic coronary artery occlusion and dissection is an exceedingly rare complication of blunt cardiac injury (BCI), though it has been previously noted in a number of case reports. However, it can also lead to heart transplant, which to our knowledge has not been previously described in the literature. We present a case of a healthy 24-year-old man without significant past medical history who was in a motorcycle accident, resulting in sternal fracture and BCI. He was ultimately found to have thrombotic occlusion and dissection of his left anterior descending artery (LAD), requiring mechanical thrombectomy and drug-eluting stent, as well as subsequent hospitalizations and operations due to various complications. It was suspected that he went into ventricular fibrillation and had a second motorcycle collision, resulting in cardiogenic shock. Ultimately, his progression of ischemic cardiomyopathy and mitral regurgitation led to the need for heart transplant. Blunt cardiac injury with myocardial contusion has such a broad range of pathologies. It is essential that patients with these injury patterns raise a high level of suspicion for BCI and are followed closely with appropriate diagnostic testing and rapid intervention for best possible outcomes.
Restarting Antithrombotic Therapies After Endoscopic Sinus Surgery: A Systematic Review
Authors: Boyi Trinithas , Richmond Rhys L. , Kayastha Darpan , Manes R. Peter , Rimmer Ryan
Published: April 2024

Objectives:

Antithrombotic therapies, comprised of both anticoagulant and antiplatelet agents, are routinely paused prior to endoscopic sinus surgery (ESS) to reduce the risk of perioperative hemorrhage. At present, no clear guidelines exist to guide otolaryngologists on when to resume these agents after ESS. Our goal was to systematically review the existing literature related to this topic.

Methods:

Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we systematically queried the PubMed, Embase, Ovid, Web of Science, Cochrane, and CINAHL databases to identify publications reporting on antithrombotic and antiplatelet therapy in the context of ESS. The primary outcomes we sought were recommendations on the timing of antithrombotic therapy resumption after ESS.

Results:

Of the 104 unique articles identified, all were screened for relevance by 2 independent reviewers based on title and abstract, 20 underwent full-text review, and 6 met inclusion criteria for analysis. Of these, 3 were literature reviews, 2 were case-control studies, and 1 was a cohort study. All publications discussed when to pause antithrombotic therapy prior to surgery while only 3 articles discussed resumption of these agents. Recommendations were mixed.

Conclusion:

A paucity of literature exists on the resumption of antithrombotic therapies after ESS. As a major determining factor in patient morbidity, guideline-based resumption of these therapies is needed.
Ag(I) Ion-Concentration-Dependent Dynamic Mechanism of Thiolactic-Acid-Capped Gold Nanoclusters Revealed by Fluorescence Spectra and Two-Dimensional Correlation Spectroscopy
Authors: Zhang Liping , Li Hong-Wei , Wu Yuqing
Published: April 2024

Based on fluorescence spectroscopy, being combined with several spectral analysis techniques including principal component analysis (PCA), two-dimensional correlation spectroscopy (2D-COS), and moving window 2D-COS, the study disclosed the structural variations of gold nanoclusters capped by thiolactic acid (AuNCs@TLA) induced by Ag(I) ions. Transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS) were applied to monitor the morphology evolution of the surface and composition of the nanoclusters induced by Ag(I) ions. Several spectral components, centered at (790, 607) nm, (670, 590) nm, and (740, 670) nm were revealed by 2D-COS analysis, suggesting new luminescent species or groups were generated with the introduction of Ag(I) ions. A two-stage mechanism was revealed for the photoluminescence variations of AuNCs@TLA induced by Ag(I) ion. The first stage was characterized by the emission quench of 790 nm followed by the emerging emission of 607 nm, which was attributed to the anti-galvanic reaction; and the second stage featured by the noticeable growth of the emission's intensity around 670 nm as result of the AuNCs’ size effect. The present study will attract more focuses on near-infrared (NIR)-emitted metal nanoclusters and promote their synthesis and utilities.
Structural inequalities, knife crime: A qualitative study
Authors: Gwata Dorcas , Ventriglio Antonio , Hughes Peter , Deahl Martin
Published: April 2024

The importance and impact of youth violence is increasingly being recognised and is a cause of international concern. In the UK, youth violence, specifically knife crime, is on the increase and has resulted in the deaths of many young people. In order to explore the impact of knife crimes on mental health and wellbeing of individuals, a number of focus groups were conducted with 24 professionals from multiple agencies. Qualitative analysis showed various emerging themes, which included ineffective mental health systems, structural violence and inequalities, policing, safety and community engagement, vulnerability and resilience in minority communities. Equity in mental health services, further development and roll-out of public mental health approaches and training accompanied by sufficient resources is needed.
Diatoms in maggots; a potential tool for drowning diagnosis – A preliminary study
Authors: Badu I. K. , Asante D. , Agyemang E. D. , Kwaku Duah K. , Adokoh C. K. , Girela-Lopez E.
Published: April 2024

Advanced putrefaction causes extensive loss of soft tissue, rendering it difficult to use the diatom test as a reliable diagnostic tool for drowning investigations. A positive diatom test in carrion insect larvae may provide significant assistance in overcoming the challenge of decomposition. The studies determined the utility of diatom test in carrion larvae on severely decomposed bodies. A modified acid digestion method involving nitric acid, K2Cr2O7 and HCl, was used to digest the blowfly larvae feeding on piglet carrion previously drowned in freshwater and sea water, respectively. Extracted diatom frustules were analysed and characterised using light microscopy coupled to a digital camera. Diatoms recovered from maggots on sea-drowned piglets were similar to diatoms from sea water (drowning medium). Centric diatoms recovered in maggots were higher (200 ± 60 diatoms/ mL) than pennate diatoms (80 ± 20 diatoms/mL). Isolated diatoms common to both maggots and water samples included Coscinodiscus sp. and Navicular spp. Albeit, there were no diatoms recovered from maggots on freshwater-drowned piglets. The findings of this study suggest that the diatom test is still a reliable diagnostic tool to determine if drowning was involved in the death of a fully decomposed body. This is the first study that isolated diatoms from maggots feeding on drowned bodies. It serves as the basis for further research into the utility of maggots for drowning investigations.
Suspected serial killers and unsuspected statistical blunders
Authors: O’Quigley John
Published: April 2024

A whole branch of theoretical statistics devotes itself to the analysis of clusters, the aim being to distinguish an apparent cluster arising randomly from one that is more likely to have been produced as a result of some systematic influence. There are many examples in medicine and some that involve both medicine and the legal field; criminal law in particular. Observed clusters or a series of cases in a given setting can set off alarm bells, the recent conviction of Lucy Letby in England being an example. It was an observed cluster, a series of deaths among neonates, that prompted the investigation of Letby. There have been other similar cases in the past and there will be similar cases in the future. Our purpose is not to reconsider any particular trial but, rather, to work with similar, indeed more extreme numbers of cases as a way to underline the statistical mistakes that can be made when attempting to make sense of the data. These notions are illustrated via a made-up case of 10 incidents where the anticipated count was only 2. The most common statistical analysis would associate a probability of less than 0.00005 with this outcome: A very rare event. However, a more careful analysis that avoids common pitfalls results in a probability close to 0.5, indicating that, given the circumstances, we were as likely to see 10 or more as we were to see less than 10.
Perceptions of Teaching Importance Among Associate and Full Professors at Regional, Public Universities
Authors: Fuegen Kathleen , Hatchett Gregory T.
Published: April 2024

Background: Research on perceptions of the promotion process among psychology faculty at teaching-intensive institutions is missing. Objective: We examine whether perceptions vary by academic rank and faculty gender. Method: We surveyed 386 associate and full psychology professors at regional, public universities in the United States to measure perceptions of (1) the importance of effective teaching, scholarly productivity, and service activities and (2) the clarity of the criteria and standards, for promotion from associate to full professor. Results: Teaching was regarded as the most important criterion for promotion to full professor. However, full professors regarded teaching as more important than did associate professors. Perceived teaching importance was positively correlated with perceived clarity of criteria and standards for promotion. Women regarded promotion criteria as less clear than men. Mentoring was positively correlated with the intention to apply for promotion. Conclusion: Faculty who perceive that their institution strongly values teaching perceive greater clarity regarding the relative importance of teaching, research, and service for promotion, as well as how excellence in these areas is judged. Teaching Implications: Teaching is the most important criterion for promotion to full professor among faculty at regional public universities.
Perceived Negative Effects of Tic Management Strategies in Adults With Tic Disorders
Authors: Barber Kathryn E. , Pitts Brandon X. , Stiede Jordan T. , Espil Flint M. , Woods Douglas W. , Specht Matthew W. , Bennett Shannon M. , Walkup John T. , Ricketts Emily J. , McGuire Joseph F. , Peterson Alan L. , Compton Scott N. , Wilhelm Sabine , Scahill Lawrence , Piacentini John C.
Published: April 2024

Behavior therapy is a well-established and empirically supported treatment for tic disorders (TDs). However, concerns have been expressed about the negative effects of behavioral interventions, such as tic worsening, tic substitution, and excessive effort. This study explored perceived negative effects of tic management strategies in adults with TDs and predictors of these experiences. Participants ( N = 72) completed semi-structured interviews 11 years after receiving behavior therapy or supportive therapy in a randomized clinical trial. We examined responses to interview questions about managing tics and predictors of reported negative effects. Most participants did not experience tic worsening (84%) or tic substitution (75%) from tic management strategies. The majority felt they could manage tics while participating in their environment (87%) and did not report life interference from tic management (77%). About half (45%) felt less present when managing tics. Treatment non-responders in the original trial were more likely to report negative effects of tic management strategies. No differences in reported negative consequences were found between those who received behavior therapy versus supportive therapy, suggesting that behavior therapy specifically does not lead to such adverse effects. These findings could reduce misconceptions about behavior therapy for TDs and enhance its acceptability and utilization.
The Association Between Lifestyle Factors and COVID-19 Among Older Adults in Southern California: The Loma Linda Longevity Study
Authors: Alabadi-Bierman Alaa , Spencer-Hwang Rhonda , Beeson W. Lawrence , Paalani Michael , Dos Santos Hildemar
Published: April 2024

Amid a global aging trend, particularly notable in the U.S., there is a growing focus on achieving enhanced longevity and well-being. We evaluated the association between lifestyle factors (sleep, diet, and healthy lifestyle index) and COVID-19 infection in an older adult population in San Bernardino and Riverside counties in Southern California, the United States. A sample of 380 older adults ≥75 years old were surveyed cross-sectionally and self-reported lifestyle behaviors and COVID-19 infection. The results revealed that half the participants reported COVID-19 infection. Participants who slept less than 7 hours or more than 8 hours/night had higher odds of COVID-19 infection than those who slept 7–8 hours/night (OR = 1.62, 95% CI: 1.03, 2.55). Healthy lifestyle behaviors were significantly associated with reduced COVID-19 infection (OR = 0.61, 95% CI: 0.40, 0.92). In conclusion, adequate sleep and healthy lifestyle behaviors may be protective against COVID-19 infection among older adults and should be investigated further.
Relationships Between Executive Functions and Computational Thinking
Authors: Liu Tongxi
Published: April 2024

Addressing cognitive disparities has become a paramount concern in computational thinking (CT) education. The intricate and nuanced relationships between CT and cognitive variations emphasize the needs to accommodate diverse cognitive profiles when fostering CT skills, recognizing that these cognitive functions can manifest as either strengths or limitations in different students. Consequently, understanding the connections between students’ cognitive functions and CT skills assumes pivotal importance in the design of personalized instructional strategies for CT. Despite a general consideration of learning variability in CT education, empirical insights exploring the correlation between cognitive skills and CT competencies remain notably scarce. This study endeavors to bridge this research gap by investigating the links between executive functions and CT skills, as well as the associations between their sub-dimensions. The results reveal a statistically significant correlation coefficient of 0.452 between these two domains, underscoring the notable connection between executive functions and CT abilities. Furthermore, the sub-dimensional analysis offers a comprehensive understanding of how specific executive functions uniquely contribute to certain CT skills. In light of these findings, this research offers a promising pathway for the development of tailored CT education programs that can cater to the unique needs of each individual, ultimately facilitating inclusive CT programs and making significant contributions to broaden STEM education and future workforce.
Application of artificial neural networks as a tool for the prediction of electrical conductivity in polymer composites
Authors: Cavalcanti Shirley N , da Silva Moacy P , Rodrigues Túlio ACS , Agrawal Pankaj , Brito Gustavo F , Vilar Eudésio O , Mélo Tomás JA
Published: April 2024

In this work, conductive polymeric composites (CPCs) of renewable source high-density polyethylene (HDPE) (BioPe) with various carbon black (CB) concentrations were developed. To corroborate the electrical conductivity prediction techniques, an artificial neural network (ANN) was modeled and trained to predict electrical conductivity using processing parameters, filler information, and polymeric matrix. Thus, the obtained neural network and the proposed methodology could serve as experimental support for the development of new materials based on parametric variation and consequent prediction of electrical conductivity. Therefore, the use of artificial neural networks from processing data and filler concentration proved to be an efficient technique for predicting the electrical conductivity of CPCs using conductive carbon black as conductive filler.
ANN-NSGA-assisted investigation of tribo-performance of lead-free nickel boron coating
Authors: Agrawal Rohit , Mukhopadhyay Arkadeb
Published: April 2024

In recent times electroless Ni-B coatings free of lead are being investigated with an aim to replace the lead stabilized bath. Traditional formulations of Ni-B coatings often rely on the use of heavy metal/lead-based stabilizers. However, the environmental and health concerns associated with these stabilizers have prompted the exploration of stabilizer-free formulations. The tribological behavior and wear mechanisms of heat-treated heavy metal-free Ni-B coatings were investigated systematically by varying load (10–50 N), speed (0.5–1.5 m/s) and distance (400–1000 m) in accordance with Taguchi's L27 orthogonal array. An artificial neural network (ANN) combined with genetic algorithm is proposed to investigate and optimize wear rate and coefficient of friction (COF) of heat-treated Ni-B coatings. Globular morphology was obtained for the coatings with crystalline peaks of Ni, Ni3B and Ni2B for coatings heat treated at 350°C for 1 h. The mean absolute percentage error of ANN model for wear rate and COF was 5.2846% and 2.0572%, respectively. The multiobjective optimization showed 30.325 N load, 0.50007 m/s speed and 759.2959 m distance corresponding to simultaneous minimum wear rate and COF of 0.005297 × 10−6 g N−1 m−1 and 0.25238 respectively. The worn surface of optimized conditions coatings exhibited oxidized flattened nodules and debris that act as load bearing area leading to lower wear rate and COF.
Technique and result test of transformer voire feature extraction under high noise environment
Authors: Zhang Yongyun , Lv Zepeng , Wang Zhiping
Published: April 2024

In the whole power system, the importance of the transformer is self-evident, if its fault is bound to cause adverse effects on the whole power system. However, the previous fault diagnosis method is not only time-consuming and laborious, but also has great danger, once it is not handled properly, it may also pose a threat to the life safety of operators. At this time, the transformer fault diagnosis mode based on voice print follows and becomes a big tool for fault diagnosis. However, the surrounding environment of the transformer is changeable and noisy, which will cause interference to the voice print signal and affect the fault diagnosis result. In this regard, this paper will start from this key point and solve this unfavorable factor by using different denoising technologies and feature extraction technologies. The final empirical results show that the improved wavelet threshold technology has the best denoising ability, and the feature parameters obtained under the transformer sound frequency cepstrum coefficient (TFCC) feature extraction technology can better improve the fault diagnosis accuracy. It can solve the problem of low fault diagnosis rate of transformer in different environments, and can be used in practical engineering.
Teaching information literacy in online psychology courses: Effects on student performance and self-reported confidence
Authors: Campbell Paul C. , Mischkowski Dominik
Published: April 2024

Using the Framework for Information Literacy published by the Association of College & Research Libraries, we developed an online intervention to increase information literacy. Specifically, we hypothesized that undergraduate students in an information literacy intervention group would increase in information literacy performance and confidence compared to a control group which did not receive asynchronous online information literacy instruction. We used a non-equivalent groups pretest-posttest design and measured students’ ( N = 101) information literacy performance and self-reported confidence before and after asynchronous information literacy instruction. We compared the intervention with a non-intervention control condition using two existing undergraduate psychology courses offered online across two semesters. Partially confirming our hypotheses, we found that providing asynchronous information literacy instruction not only increased students’ information literacy performance but also helped students to evaluate their own information literacy skills more accurately. In contrast, our intervention did not selectively increase confidence in information literacy as both information literacy intervention and control groups similarly increased in information literacy confidence over time. Nevertheless, these findings show that we managed to develop an online, theory-based intervention to increase information literacy. This intervention has the potential to build the foundations for students to engage in scientific conversations by elevating their understanding of how scientific information is produced and how science affects their daily lives.