bluuebunny/crossref_metadata_2025 huggingface dataset:
Deep Learning Approaches for Wildland Fires Using Satellite Remote Sensing Data: Detection, Mapping, and Prediction
Authors: Ghali Rafik , Akhloufi Moulay A.
Published: May 2023

Wildland fires are one of the most dangerous natural risks, causing significant economic damage and loss of lives worldwide. Every year, millions of hectares are lost, and experts warn that the frequency and severity of wildfires will increase in the coming years due to climate change. To mitigate these hazards, numerous deep learning models were developed to detect and map wildland fires, estimate their severity, and predict their spread. In this paper, we provide a comprehensive review of recent deep learning techniques for detecting, mapping, and predicting wildland fires using satellite remote sensing data. We begin by introducing remote sensing satellite systems and their use in wildfire monitoring. Next, we review the deep learning methods employed for these tasks, including fire detection and mapping, severity estimation, and spread prediction. We further present the popular datasets used in these studies. Finally, we address the challenges faced by these models to accurately predict wildfire behaviors, and suggest future directions for developing reliable and robust wildland fire models.
Resource Partitioning of Sympatric Lutjanids in the Northern Gulf of Mexico Using Stable Isotope Analysis
Authors: Garner Steven , Zapp Sluis Michelle , Wells R. , Boswell Kevin , Cowan James
Published: May 2023

Lutjanid snappers are ubiquitous at reef sites in the northern Gulf of Mexico (Gulf), but the degree of niche overlap and basal resource utilization is unknown for most species. Muscle tissue for stable isotope analysis was opportunistically sampled from red snapper (Lujanus campechanus), gray snapper (Lutjanus griseus), lane snapper (Lutjanus synagris), and vermilion snapper (Rhomboplites aurorubens) recreational catches across the northern Gulf. A Bayesian mixing model used to compare resource utilization indicated that Lutjanids occupy niches with varying degrees of overlap among regions but maintain a consistent hierarchy in isotopic composition. Scale shifts among regions were likely due to differences in riverine outflow, nitrogen fixation, and anoxic zones that alter prey abundance or isotopic δ15N ratios. All four Lutjanid species had high percent contributions from particulate organic matter and benthic microalgae with little contribution by macroalgae to any species in any region. Ontogenetic shifts in stable isotope values were observed in most species indicating that size plays an important role in avoiding niche overlap due to intense competition for high-value prey items among congeners at isolated reef sites. Diet specialization is modest but likely plays an important role in avoiding complete niche overlap.
The Role of Txnip in Mediating Low-Magnesium-Driven Endothelial Dysfunction
Authors: Locatelli Laura , Fedele Giorgia , Maier Jeanette A.
Published: May 2023

Magnesium deficiency is associated with a greater risk of developing cardiovascular diseases since this cation is fundamental in regulating vascular function. This clinical evidence is sustained by in vitro studies showing that culturing endothelial cells in low concentrations of magnesium promotes the acquisition of a pro-oxidant and pro-inflammatory phenotype. Here, we show that the increase in reactive oxygen species in endothelial cells in low-magnesium-containing medium is due to the upregulation of the pro-oxidant protein thioredoxin interacting protein (TXNIP), with a consequent accumulation of lipid droplets and increase in endothelial permeability through the downregulation and relocalization of junctional proteins. Silencing TXNIP restores the endothelial barrier and lipid content. Because (i) mitochondria serve multiple roles in shaping cell function, health and survival and (ii) mitochondria are the main intracellular stores of magnesium, it is of note that no significant alterations were detected in their morphology and dynamics in our experimental model. We conclude that TXNIP upregulation contributes to low-magnesium-induced endothelial dysfunction in vitro.
Rosuvastatin Synergistically Enhances the Antinociceptive Efficacy of Duloxetine in Paclitaxel-Induced Neuropathic Pain in Mice
Authors: Lobos Nicolás , Lux Sebastián , Zepeda Ramiro Javier , Pelissier Teresa , Marcos José Luis , Bustos-Quevedo Gonzalo , Hernández Alejandro , Constandil Luis
Published: May 2023

Paclitaxel, a widely used cancer chemotherapeutic agent, has high incidence of neurotoxicity associated with the production of neuropathic pain, for which only duloxetine has shown significant but moderate analgesic effect. Since statins, classically used to reduce hypercholesterolemia, have shown antinociceptive effect in preclinical studies on neuropathic pain, we studied whether the antinociceptive efficacy of duloxetine could be synergistically potentiated by rosuvastatin in a model of paclitaxel-induced neuropathy in mice. The astrocytic and microglial responses in the spinal cord of paclitaxel-treated mice were also assessed by measuring GFAP and CD11b proteins, respectively. Paclitaxel treatment did not impair motor coordination and balance in rotarod testing. Rosuvastatin, duloxetine, and the rosuvastatin/duloxetine combination (combined at equieffective doses) dose-dependently decreased mechanical allodynia (ED30, von Frey testing) and thermal hyperalgesia (ED50, hot plate testing) in paclitaxel-treated mice. Isobolographic analysis showed a superadditive interaction for rosuvastatin and duloxetine, as both the ED30 and ED50 for the rosuvastatin/duloxetine combination contained only a quarter of each drug compared to the individual drugs. The rosuvastatin/duloxetine combination reversed paclitaxel-induced GFAP overexpression, indicating that such effects might depend in part on astrocyte inactivation. Results suggest that statins could be useful in synergistically enhancing the efficacy of duloxetine in some chemotherapy-induced neuropathic conditions.
Phospholipids, the Masters in the Shadows during Healing after Acute Myocardial Infarction
Authors: Pistritu Dan-Valentin , Vasiliniuc Anisia-Cristiana , Vasiliu Anda , Visinescu Elena-Florentina , Visoiu Ioana-Elena , Vizdei Smaranda , Martínez Anghel Paula , Tanca Antoanela , Bucur Octavian , Liehn Elisa Anamaria
Published: May 2023

Phospholipids are major components of cell membranes with complex structures, high heterogeneity and critical biological functions and have been used since ancient times to treat cardiovascular disease. Their importance and role were shadowed by the difficulty or incomplete available research methodology to study their biological presence and functionality. This review focuses on the current knowledge about the roles of phospholipids in the pathophysiology and therapy of cardiovascular diseases, which have been increasingly recognized. Used in singular formulation or in inclusive combinations with current drugs, phospholipids proved their positive and valuable effects not only in the protection of myocardial tissue, inflammation and fibrosis but also in angiogenesis, coagulation or cardiac regeneration more frequently in animal models as well as in human pathology. Thus, while mainly neglected by the scientific community, phospholipids present negligible side effects and could represent an ideal target for future therapeutic strategies in healing myocardial infarction. Acknowledging and understanding their mechanisms of action could offer a new perspective into novel therapeutic strategies for patients suffering an acute myocardial infarction, reducing the burden and improving the general social and economic outcome.
Far-Red Light Mediated Carbohydrate Concentration Changes in Leaves of Sweet Basil, a Stachyose Translocating Plant
Authors: Driesen Elisa , Saeys Wouter , De Proft Maurice , Lauwers Arthur , Van den Ende Wim
Published: May 2023

Photosynthetic active radiation (PAR) refers to photons between 400 and 700 nm. These photons drive photosynthesis, providing carbohydrates for plant metabolism and development. Far-red radiation (FR, 701–750 nm) is excluded in this definition because no FR is absorbed by the plant photosynthetic pigments. However, including FR in the light spectrum provides substantial benefits for biomass production and resource-use efficiency. We investigated the effects of continuous FR addition and end-of-day additional FR to a broad white light spectrum (BW) on carbohydrate concentrations in the top and bottom leaves of sweet basil (Ocimum basilicum L.), a species that produces the raffinose family oligosaccharides raffinose and stachyose and preferentially uses the latter as transport sugar. Glucose, fructose, sucrose, raffinose, and starch concentrations increased significantly in top and bottom leaves with the addition of FR light. The increased carbohydrate pools under FR light treatments are associated with more efficient stachyose production and potentially improved phloem loading through increased sucrose homeostasis in intermediary cells. The combination of a high biomass yield, increased resource-use efficiency, and increased carbohydrate concentration in leaves in response to the addition of FR light offers opportunities for commercial plant production in controlled growth environments.
Aβ40 Aggregation under Changeable Conditions
Authors: Seira Curto Jofre , Fernandez Maria Rosario , Cladera Josep , Benseny-Cases Núria , Sanchez de Groot Natalia
Published: May 2023

Homeostasis is crucial for cell function, and disturbances in homeostasis can lead to health disorders. Under normal conditions, intracellular pH is maintained between 7.35 and 7.45. Altered endosomal and lysosomal pH together with a general drop in brain pH are associated with the aggregation of amyloid-β-peptide (Aβ) and the development of Alzheimer’s disease. Under acidic conditions, close to the Aβ isoelectric point, the absence of charges favors the formation of intermolecular contacts and promotes aggregation. Here, we analyzed how pH levels affect the aggregation of Aβ40 considering the variations in brain pH and the coexistence of different aggregated conformations. Our results suggest that different macromolecular conformations can interact with each other and influence the aggregation process. In addition, we showed that neutral pH and physiological salt concentrations favor a slow aggregation, resulting in ordered, stable fibrils, with low cytotoxic effects. Overall, we highlight the complexity of the aggregation processes occurring in different physiological and pathological environments.
Diversity in Cell Morphology, Composition, and Function among Adipose Depots in River Buffaloes
Authors: Yang Xintong , Zhu Ruirui , Song Ziyi , Shi Deshun , Huang Jieping
Published: May 2023

Fat deposition is a significant economic trait in livestock animals. Adipose tissues (ATs) developed in subcutaneous and visceral depots are considered waste whereas those within muscle are highly valued. In river buffaloes, lipogenesis is highly active in subcutaneous (especially in the sternum subcutaneous) and visceral depots but not in muscle tissue. Revealing the features and functions of ATs in different depots is significant for the regulation of their development. Here, we characterize the cell size, composition, and function of six AT depots in river buffaloes. Our data support that the subcutaneous AT depots have a larger cell size than visceral AT depots, and the subcutaneous AT depots, especially the sternum subcutaneous AT, are mainly associated with the extracellular matrix whereas the visceral AT depots are mainly associated with immunity. We found that sternum subcutaneous AT is significantly different from ATs in other depots, due to the high unsaturated fatty acid content and the significant association with metabolic protection. The perirenal AT is more active in FA oxidation for energy supply. In addition, the expression of HOX paralogs supports the variable origins of ATs in different depots, indicating that the development of ATs in different depots is mediated by their progenitor cells. The present study enhances our understanding of the cellular and molecular features, metabolism, and origin of AT depots in buffaloes, which is significant for the regulation of fat deposition and provides new insights into the features of AT depots in multiple discrete locations.
Longitudinal Analyses of Mutational Subclonal Architecture and Tumor Subtypes in Recurrent Bladder Cancer
Authors: Ryu Daeun , Kim Tae-Min , Lee Yun-Hee , Ha U-Syn
Published: May 2023

Longitudinal tumor sequencing of recurrent bladder cancer (BC) can facilitate the investigation of BC progression-associated genomic and transcriptomic alterations. In this study, we analyzed 18 tumor specimens including distant and locoregional metastases obtained during tumor progression for five BC patients using whole-exome and transcriptome sequencing. Along with the substantial level of intratumoral mutational heterogeneity across the cases, we observed that clonal mutations were enriched with known BC driver genes and apolipoprotein B mRNA editing enzyme, catalytic polypeptide (APOBEC)-associated mutation signatures compared with subclonal mutations, suggesting the genetic makeup for BC tumorigenesis associated with APOBEC deaminase activity was accomplished early in the cancer evolution. Mutation-based phylogenetic analyses also revealed temporal dynamics of mutational clonal architectures in which the number of mutational clones varied along the BC progression and notably was often punctuated by clonal sweeps associated with chemotherapy. The bulk-level transcriptome sequencing revealed frequent subtype switching in which transcriptionally defined BC subtypes may vary during tumor progression. Longitudinal whole-exome and transcriptome sequencing of recurrent BC may advance our understanding into the BC heterogeneity in terms of somatic mutations, cell clones and transcriptome-based tumor subtypes during disease progression.
A Self-Pumping Composite Dressing Improved Hypertrophic Scar Healing with Dual Therapy and Active-Fluid Transport
Authors: Lui Kam Che , Noor Nuruzzaman , Kan Chi Wai , Wang Xungai
Published: May 2023

Silicone gel sheeting (SGS) and pressure garment therapy (PGT) are the International Clinical Recommendations on Scar Management’s (ICRSM) two principal non-invasive scar-healing procedures. This study created a new PGT-SGS composite (PGF-Biopor®AB-based) via pre-strained screen printing. The Biopor®AB hydrophobicity and nylon-hydrophilicity enabled self-pumping for PGT-SGS dual therapy and pressure-driven “warp insertions” mobility facilitates active-fluid transportation. Integrating both therapies in a single PGT-SGS composite achieved efficacy optimization, and the 3D channel structure allowed trauma-free active-fluid transport. The 3D channel topology enables smooth diffusional transport in active-fluid transport environments—and active “nylon absorbency” improved water uptake and enhanced permeability capabilities with sustainability achieved dynamic hydration. The sole use of PGF-Biopor®AB composite in empirical trials verified dual therapy with trauma-free active-fluid transport with one-month efficacy, providing a new route for dual treatment and active scar management.
Alternating Additive Manufacturing and Forming—An Innovative Manufacturing Approach
Authors: Papke Thomas , Hafenecker Jan , Römisch David , März Raphaela , Hentschel Oliver , Bartels Dominic , Schmidt Michael , Merklein Marion
Published: May 2023

In this work, an innovative manufacturing approach that includes a fully linked and integrated manufacturing system consisting of a laser-based directed energy deposition (DED-LB/M) module and a forming press is presented. The alternating additive manufacturing (AM) process is based on a combination of a DED-LB/M process using a laser power of 600 W and a feed rate of 400 mm/min and a subsequent forming process, in which the structure is upset with a hydraulic press using a constant forming force of 500 kN in order to smooth the surface and influence the accuracy of the components. For the generation of a fundamental process understanding, a cuboid, basic shape was chosen as geometry for the investigations. The aim is to improve part properties by applying the process steps to generate part properties, which are superior to solely additive manufactured material. It is shown that the geometry of additive manufactured structures can be adapted, and the top surface can be smoothed due to the forming operation. The mean roughness value Rz decreases up to 50% after the forming operation. The hardness can be increased by work hardening. Of special interest is that the higher hardness can be kept up even though a further DED-LB/M process step and forming operation are applied to the additively manufactured and formed structure again. Finally, an analysis of the new manufacturing approach regarding its potential is given.
Magnetization of Wiegand Wires with Varying Diameters and Analysis of Their Magnetic Structure via Hysteresis Loops
Authors: Jiang Liang , Yang Chao , Song Zenglu , Takemura Yasushi
Published: May 2023

Wiegand wires are unique ferromagnetic materials that display rapid magnetization reversal and a large Barkhausen jump under an applied field. This stable reversal can be used to induce a periodic pulse voltage in a pickup coil wrapped around the Wiegand wire. To unlock the full potential of Wiegand wires for magnetic sensors and devices, the magnetic structure and magnetization state of the Wiegand wire must be fully elucidated. In this study, hysteresis loops were used to reveal the magnetic structure of Wiegand wires. Wiegand wires of different diameters magnetized under different applied magnetic field strengths were analyzed in detail. Our results show that Wiegand wires 0.06 mm in diameter are composed solely of a hard magnetic core. Wiegand wires above 0.10 mm in diameter have a hard magnetic core, a middle layer, and a soft layer that decreases in thickness but increases in coercivity as the wire diameter decreases. Then, theoretical models were built to predict the magnetic structure of Wiegand wires under an applied field for the first time. The magnetization process of Wiegand wires with different diameters under different applied magnetic fields was also analyzed.
Effects of Ti on the Microstructural Evolution and Mechanical Property of the SiBCN-Ti Composite Ceramics
Authors: Peng Hao , Li Daxin , Yang Zhihua , Duan Wenjiu , Jia Dechang , Zhou Yu
Published: May 2023

In this study, amorphous + nanocrystalline Ti-BN mixed powders were obtained through first-step mechanical alloying; subsequently, almost completely amorphous SiBCN-Ti mixed powders were achieved in the second-step milling. The SiBCN-Ti bulk ceramics were consolidated through hot pressing sintering at 1900 °C/60 MPa/30 min, and the microstructural evolution and mechanical properties of the as-sintered composite ceramics were investigated using SEM, XRD, and TEM techniques. The as-sintered SiBCN-Ti bulk ceramics consisted of substantial nanosized BN(C), SiC, and Ti(C, N) with a small amount of Si2N2O and TiB2. The crystallized BN(C) enwrapped both SiC and Ti(C, N), thus effectively inhibiting the rapid growth of SiC and Ti(C, N). The sizes of SiC were ~70 nm, while the sizes of Ti(C, N) were below 30 nm, and the sizes of Si2N2O were over 100 nm. The SiBCN-20 wt.% Ti bulk ceramics obtained the highest flexural strength of 394.0 ± 19.0 MPa; however, the SiBCN-30 wt.% Ti bulk ceramics exhibited the optimized fracture toughness of 3.95 ± 0.21 GPa·cm1/2, Vickers hardness of 4.7 ± 0.27 GPa, Young’s modulus of 184.2 ± 8.2 GPa, and a bulk density of 2.85 g/cm3. The addition of metal Ti into a SiBCN ceramic matrix seems to be an effective strategy for microstructure optimization and the tuning of mechanical properties, thus providing design ideas for further research regarding this family of ceramic materials.
A Review of Numerical Simulation of Laser–Arc Hybrid Welding
Authors: Wang Zhaoyang , Gong Mengcheng , Zhou Longzao , Gao Ming
Published: May 2023

Laser–arc hybrid welding (LAHW) is known to achieve more stable processes, better mechanical properties, and greater adaptability through the synergy of a laser and an arc. Numerical simulations play a crucial role in deepening our understanding of this interaction mechanism. In this paper, we review the current work on numerical simulations of LAHW, including heat source selection laws, temperature field, flow field, and stress field results. We also discuss the influence of laser–arc interaction on weld defects and mechanical properties and provide suggestions for the development of numerical simulations of LAHW.
Effect of the Second Phases on Composite Spinning-Extrusion Forming and Mechanical Properties of Al–Cu–Li Alloy
Authors: Zeng Huaqiang , Shi Dongfeng , Zheng Ying , Zhang Jin
Published: May 2023

The aim of this work is to investigate the effect of different second phases on the composite spinning-extrusion forming and mechanical properties of Al–Cu–Li alloy. With that purpose, four kinds of second phases blanks were controlled using preheating treatment, composite spinning-extrusion forming and mechanical properties test. Then, the correlation between the second phases and mechanical properties was further analyzed using electron backscattered diffraction and transmission electron microscopy. The results indicated that different second phases of Al–Cu–Li alloy can be regulated via reasonable preheating treatment. In addition, different second phases in the blank have various influences on composite spinning-extrusion forming, microstructure and mechanical properties of cylindrical parts. Dissolving the coarse second phases particles and precipitating the Al3Zr dispersoid in the blank can effectively improve the composite spinning-extrusion forming, inhibit the abnormal growth of recrystallized grains, and significantly enhance the mechanical properties of cylindrical parts with ribs. After regulation, the average grain size of the cylindrical parts is refined from about 90 μm to about 45 μm, and the average diameter of T1 phase is refined from 107 nm to 77 nm. In addition, the ultimate tensile strength, yield strength and elongation of cylindrical parts are increased from 555 MPa to 588 MPa, 530 MPa to 564 MPa, and 9.1% to 11%, respectively.
Investigating the Effect of Reflectance Tuning on Photocatalytic Dye Degradation with Biotemplated ZnO Photonic Nanoarchitectures Based on Morpho Butterfly Wings
Authors: Piszter Gábor , Nagy Gergely , Kertész Krisztián , Baji Zsófia , Kovács Krisztina , Bálint Zsolt , Horváth Zsolt Endre , Pap József Sándor , Biró László Péter
Published: May 2023

Photonic nanoarchitectures of butterfly wings can serve as biotemplates to prepare semiconductor thin films of ZnO by atomic layer deposition. The resulting biotemplated ZnO nanoarchitecture preserves the structural and optical properties of the natural system, while it will also have the features of the functional material. The ZnO-coated wings can be used directly in heterogeneous photocatalysis to decompose pollutants dissolved in water upon visible light illumination. We used the photonic nanoarchitectures of different Morpho butterflies with different structural colors as biotemplates and examined the dependence of decomposition rates of methyl orange and rhodamine B dyes on the structural color of the biotemplates and the thickness of the ZnO coating. Using methyl orange, we measured a ten-fold increase in photodegradation rate when the 20 nm ZnO-coated wings were compared to similarly coated glass substrates. Using rhodamine B, a saturating relationship was found between the degradation rate and the thickness of the deposited ZnO on butterfly wings. We concluded that the enhancement of the catalytic efficiency can be attributed to the slow light effect due to a spectral overlap between the ZnO-coated Morpho butterfly wings reflectance with the absorption band of dyes, thus the photocatalytic performance could be changed by the tuning of the structural color of the butterfly biotemplates. The photodegradation mechanism of the dyes was investigated by liquid chromatography–mass spectroscopy.
Fracture Response of X80 Pipe Girth Welds under Combined Internal Pressure and Bending Moment
Authors: Zhu Li , Li Naixian , Jia Bin , Zhang Yu
Published: May 2023

In order to determine the effect of defect size on the pipeline fracture performance of girth welds in oil and gas pipelines, ABAQUS was used to simulate the fracture responses of X80 pipelines with girth weld defects under internal pressure and bending moment conditions based on damage mechanics. In particular, the length and depth of defects were parametrically studied; the defect depth range was 20–80% of the wall thickness, and the circumferential length range of the defects was 5–20% of the pipeline circumference. The results show that, under the combined action of internal pressure and bending moment, the defect depth was more associated with adverse effects than the circumferential length of the defect. The failure load did not linearly decrease as the size of the defect increased, but when the depth of the defect reached a certain value, the failure load suddenly decreased.
Microstructural Changes and Mechanical Properties of Precipitation-Strengthened Medium-Entropy Fe71.25(CoCrMnNi)23.75Cu3Al2 Maraging Alloy
Authors: Lee Unhae , Bae Jae Wung
Published: May 2023

Metal alloys with enhanced mechanical properties are in considerable demand in various industries. Thus, this study focused on the development of nanosized precipitates in Fe71.25(CoCrMnNi)23.75Cu3Al2 maraging medium-entropy alloy (MEA). The Fe-based alloying design in the MEA samples initially formed a body-centered cubic (BCC) lath martensite structure. After a subsequent annealing process at 450 °C for varying durations (1, 3, 5, and 7 h), nanosized precipitates (B2 intermetallic) enriched with Cu and with a diameter of approximately 5 nm formed, significantly increasing the hardness of the alloy. The highest Vickers microhardness of 597 HV, along with compressive yield strength and ultimate compressive strength of 2079 MPa and 2843 MPa, respectively, was achieved for the Aged_7h sample. Therefore, the BCC lath martensite structure with B2 intermetallics leads to remarkable mechanical properties.
Experimental Study of Fiber Pull-Outs in a Polymer Mortar Matrix
Authors: Wang Lihua , Li Tongshuai , Shu Qinghua , Sun Shifu , Li Chunfeng , Dai Chunquan
Published: May 2023

In order to study the influence of vinyl acetate–ethylene copolymerization emulsions on the bonding performance of fiber and mortar, mortar materials with different polymer contents were prepared. The optimal mix ratio of the matrix was obtained using a pull-out test with a 0° inclination angle. On this basis, polypropylene fibers and alkali-resistant glass fibers were set at different burial depths (6 mm, 12 mm, and 18 mm) and different burial angles (0°, 30°, 45°, and 60°). The load–displacement curves of two types of fibers pulled out from the polymer mortar were obtained. The test results show that polymer contents of 3% and 5% increase the peak pull-out loads of glass fibers and polypropylene fibers by 16.28% and 30.72% and 7.41% and 27.11%, respectively. When the polymer content is 7%, the peak pull-out load decreases by 1.31% and 24.26%, especially for polypropylene fiber, which significantly weakens the bonding performance between the matrix and the fiber. The pull-out load of glass fibers and polypropylene fibers increases with the increase in the buried depth, and both show tensile failure at 18 mm. As the embedding angle increases, the pull-out load of polypropylene fibers decreases continuously, while the glass fiber shows a higher pull-out load at 30°.
PLA Films Containing Montmorillonite Nanoclay–Citronella Essential Oil Hybrids for Potential Active Film Formulation
Authors: Ferreira Rafaela R. , Farina Marilia C. , Maia Anderson , Torin Rondes F. S.
Published: May 2023

This work evaluated the synergistic effect of citronella essential oil (Ct) and montmorillonite (MMT) (called hybrid compound) incorporated in Poly(lactic acid) (PLA) films at different concentrations (3, 10, 15, and 20 wt%). PLA films were characterized using X-ray diffraction, SEM, TGA, and DSC considering their mechanical properties and essential oil migration. XRD analysis showed the effective interaction between MMT and oil. Thermal analysis, SEM, and mechanical tests were essential to understand the saturation point of the PLA composites. Samples with 15% and 20% of Ct showed a crystallinity reduction of 0.5% compared to samples with 3% and 10% of Ct. PLA/MMT–Ct showed a reduction in tensile strength of the order of 16 and 24, correlated to 15% and 20% of the Ct content, respectively, compared to PLA/MMT–Ct3%. Migration tests showed fast oil delivery correlated with high oil concentration, as evidenced using the PLA/MMT–Ct20% sample results, which showed an estimated release of 50% in the first 150 h due to system saturation, and the remaining being released in the last 350 h. Therefore, the migration tests provide an effective Ct concentration range promising for application with active packaging due to the intrinsic antimicrobial properties of Ct.
Analgesic Efficacy of Intraoperative Superior Hypogastric Plexus (SHP) Block during Abdominal Hysterectomy: A Systematic Review and Meta-Analysis of Controlled Trials
Authors: Salem Hany , Bukhari Ibtihal Abdulaziz , Al Baalharith Maha , AlTahtam Nasser , Alabdrabalamir Safa , Jamjoom Mohammed Ziad , Baradwan Saeed , Badghish Ehab , Abuzaid Mohammed , AbuAlsaud Fatimah Shakir , Alomar Osama , Alyousef Abdullah , Abu-Zaid Ahmed , Al-Badawi Ismail Abdulrahman
Published: May 2023

Background and Objectives: Abdominal hysterectomy is a major surgery that is often associated with pronounced postsurgical pain. The objective of this research is to conduct a systematic review and meta-analysis of all randomized controlled trials (RCTs) and nonrandomized comparative trials (NCTs) that have surveyed the analgesic benefits and morbidity of intraoperative superior hypogastric plexus (SHP) block (intervention) compared with no SHP block (control) during abdominal hysterectomy. Materials and Methods: The Cochrane Central Register of Controlled Trials (CENTRAL), Google Scholar, Web of Science, PubMed, Scopus, and Embase were searched from inception until 8 May 2022. The Cochrane Collaboration tool and Newcastle–Ottawa Scale were used to evaluate the risk of bias of RCTs and NCTs, respectively. In a random effects mode, the data were pooled as risk ratio (RR) or mean difference (MD) with 95% confidence interval (CI). Results: Five studies (four RCTs and one NCT) comprising 210 patients (SHP block = 107 and control = 103) were analyzed. The overall postsurgical pain score (n = 5 studies, MD = −1.08, 95% CI [−1.41, −0.75], p < 0.001), postsurgical opioid consumption (n = 4 studies, MD = −18.90 morphine milligram equivalent, 95% CI, [−22.19, −15.61], p < 0.001), and mean time to mobilization (n = 2 studies, MD = −1.33 h, 95% CI [−1.98, −0.68], p < 0.001) were significantly decreased in the SHP block group contrasted with the control arm. Nevertheless, there was no significant variance between both arms regarding operation time, intraoperative blood loss, postsurgical NSAID consumption, and hospital stay. There were no major side effects or sympathetic block-related aftermaths in both groups. Conclusions: During abdominal hysterectomy and receiving perioperative multimodal analgesia, the administration of intraoperative SHP block is largely safe and exhibits better analgesic effects compared to cases without administration of SHP block.
Current Concepts in the Management of Primary Lymphedema
Authors: Senger Jenna-Lynn B. , Kadle Rohini L. , Skoracki Roman J.
Published: May 2023

Primary lymphedema is a heterogeneous group of conditions encompassing all lymphatic anomalies that result in lymphatic swelling. Primary lymphedema can be difficult to diagnose, and diagnosis is often delayed. As opposed to secondary lymphedema, primary lymphedema has an unpredictable disease course, often progressing more slowly. Primary lymphedema can be associated with various genetic syndromes or can be idiopathic. Diagnosis is often clinical, although imaging can be a helpful adjunct. The literature on treating primary lymphedema is limited, and treatment algorithms are largely based on practice patterns for secondary lymphedema. The mainstay of treatment focuses on complete decongestive therapy, including manual lymphatic drainage and compression therapy. For those who fail conservative treatment, surgical treatment can be an option. Microsurgical techniques have shown promise in primary lymphedema, with both lymphovenous bypass and vascularized lymph node transfers demonstrating improved clinical outcomes in a few studies.
Hydrophobic Flocculation of Fine Cassiterite Using Alkyl Hydroxamic Acids with Different Carbon Chain Lengths as Collectors
Authors: Jin Saizhen , Shi Qing , Ou Leming
Published: May 2023

This work investigated the hydrophobic flocculation of cassiterite using four alkyl hydroxamic acids with varying carbon chain lengths, i.e., hexyl hydroxamate (C6), octyl hydroxamate (C8), decyl hydroxamate (C10) and dodecyl hydroxamate (C12), as collectors. Microflotation tests were performed to investigate the flotation behaviour of cassiterite in the presence of the four alkyl hydroxamic acids. Focused beam reflectance measurement (FBRM) and a particle video microscope (PVM) were used to analyse and monitor the real-time evolution of the particle size distribution of cassiterite and the images of flocs during flocculation. The extended DLVO theory interaction energies between the cassiterite particles were calculated on the basis of the measured contact angle and the zeta potential of cassiterite to determine the aggregation and dispersion behaviour of the cassiterite particles. The microflotation test results suggested that the floatability of cassiterite improved with the increase in the carbon chain length of hydroxamates. FBRM, PVM images and extended DLVO theory calculation results indicated that when C6 was used as the collector, the cassiterite particles could not form hydrophobic flocs because the total potential energy between them was repulsive. When C8, C10 and C12 were used as collectors, the energy barrier amongst particles decreased with increasing hydroxamate concentration. The lowest concentrations of C8, C10 and C12 that could cause the hydrophobic aggregation of cassiterite were approximately 1 × 10−3, 1 × 10−4 and 2 × 10−5 mol/L, respectively. The aggregation growth rate and apparent floc size increased with an increasing collector concentration. Hydroxamic acid with a longer carbon chain could induce the cassiterite particles to form larger flocs at a lower concentration in a shorter time.
Review of Characteristics and Analytical Methods for Determination of Thiabendazole
Authors: Budetić Mateja , Kopf Doris , Dandić Andrea , Samardžić Mirela
Published: May 2023

Thiabendazole (TBZ) is a fungicide and anthelmintic drug commonly found in food products. Due to its toxicity and potential carcinogenicity, its determination in various samples is important for public health. Different analytical methods can be used to determine the presence and concentration of TBZ in samples. Liquid chromatography (LC) and its subtypes, high-performance liquid chromatography (HPLC) and ultra-high-performance liquid chromatography (UHPLC), are the most commonly used methods for TBZ determination representing 19%, 18%, and 18% of the described methods, respectively. Surface-enhanced Raman spectroscopy (SERS) and fluorimetry are two more methods widely used for TBZ determination, representing 13% and 12% of the described methods, respectively. In this review, a number of methods for TBZ determination are described, but due to their limitations, there is a high potential for the further improvement and development of each method in order to obtain a simple, precise, and accurate method that can be used for routine analysis.
β-Carboline-α-aminophosphonate Derivative: A Promising Antitumor Agent for Breast Cancer Treatment
Authors: Zani Caroline Pinto , Zani Aline Pinto , Thomazini Cristiane Melissa , Retamiro Karina Miyuki , de Oliveira Aline Rufino , Gonçalves Débora Laís , Sarragiotto Maria Helena , Garcia Francielle Pelegrin , de Oliveira Silva Sueli , Nakamura Celso Vataru , Ueda-Nakamura Tania
Published: May 2023

Breast cancer is the most common type of cancer and the leading cause of cancer mortality among women worldwide. Considering the limitations of the current treatments available, we analyzed the in vitro cytotoxic potential of ((4-Fluoro-phenyl)-{2-[(1-phenyl-9H-β-carboline-3-carbonyl)-amino]-ethylamino}-methyl)-phosphonic acid dibutyl ester (BCP-1) in breast cancer cells (MCF-7 and MDA-MB-231) and in a non-tumor breast cell line (MCF-10A). BCP-1 has an α-aminophosphonate unit linked to the β-carboline nucleus, and the literature indicates that compounds of these classes have high biological potential. In the present study, the mechanism of action of BCP-1 was investigated through methods of spectrofluorimetry, flow cytometry, and protein expression analysis. It was found that BCP-1 inhibited the proliferation of both cancer cell lines. Furthermore, it induced oxidative stress and cell cycle arrest in G2/M. Upregulation of apoptosis-related proteins such as Bax, cytochrome C, and caspases, as well as a decrease in the anti-apoptotic protein Bcl-2, indicated potential induction of apoptosis in the MDA-MB-231 cells. While in MCF-7 cells, BCP-1 activated the autophagic death pathway, which was demonstrated by an increase in autophagic vacuoles and acidic organelles, in addition to increased expression of LC3I/LC3II and reduced SQSTM1/p62 expression. Further, BCP-1 demonstrated antimetastatic potential by reducing MMP-9 expression and cell migration in both breast cancer cell lines. In conclusion, BCP-1 is a promising candidate for breast cancer chemotherapy.
Effects of Coexisting Anions on the Formation of Hematite Nanoparticles in a Hydrothermal Process with Urea Hydrolysis and the Congo Red Dye Adsorption Properties
Authors: Onizuka Takahiro , Fukuda Mikihisa , Iwasaki Tomohiro
Published: May 2023

Crystalline hematite nanoparticles as adsorbents for anionic Congo red dye were prepared by a hydrothermal process using urea hydrolysis. To examine the effects of coexisting anions in a solution on the formation of hematite nanoparticles, different iron(III) salts, including iron chloride hexahydrate, iron nitrate nonahydrate, iron sulfate n-hydrate, ammonium iron sulfate dodecahydrate, and basic ferric acetate, were employed as iron-ion sources. After the hydrothermal treatment of the solution, consisting of an iron salt and urea at 423 K for 20 h, a single phase of hematite was formed from the iron-nitrate solution. The results suggested that the hydrothermal formation of hematite depended on the stability of iron complexes formed in the starting solution. The average crystallite size and median diameter of hematite nanoparticles also depended on the coexisting anions, suggesting that the appropriate selection of the coexisting anions in the starting solution can allow for control of the crystallite size and particle diameter of hematite nanoparticles. The Congo red adsorption kinetics and isotherms of the hematite nanoparticles were described by the Elovich model and Langmuir model, respectively. The adsorption thermodynamics parameters were estimated, which suggested an exothermic and spontaneous process. The results demonstrated good adsorption properties for Congo red adsorption.
Hemetsberger–Knittel and Ketcham Synthesis of Heteropentalenes with Two (1:1), Three (1:2)/(2:1) and Four (2:2) Heteroatoms
Authors: Tokárová Zita , Gašparová Renáta , Kabaňová Natália , Gašparová Marcela , Balogh Róbert
Published: May 2023

The synthetic methods leading to furo[3,2-b]pyrroles and thiazolo [5,4-d]thiazoles are reviewed herein. Furo-, thieno- and seleno [3,2-b]pyrroles are related to heteropentalenes, containing two heteroatoms in the entire structure, one each per core. The synthetic approach follows the Hemetsberger–Knittel protocol covering three reaction steps—the nucleophilic substitution of halogen-containing aliphatic carboxylic acid esters, Knoevenagel condensation and, finally, thermolysis promoting the intramolecular cyclocondensation to O,N-heteropentalene. The Hemetsberger–Knittel reaction sequence is also known for the preparation of O,N-heteropentalenes with three heteroatoms (2:1) and their sulphur and selen heteroatoms containing structural analogues and bispyrroles. The synthetic approach towards thiazolo [5,4-d] thiazoles represents a more straightforward route, according to the Ketcham cyclocondensation. Proceeding with the Ketcham process is more challenging since it occurs stepwise and the formation of by-products is obvious. Thiazolo [5,4-d]thiazole is a representative of the aromatic heteropentalene with four heteroatoms in the structure—twinned N and S, two for each of the five-membered rings. The synthetic approaches towards those particular heteropentalnes have been chosen as a consequence of our ongoing research dealing with the design, synthesis and applications of substituted furo [3,2-b]pyrroles and thiazolo [5,4-d]thiazole-based derivatives. While the furopyrroles are known for their pharmacological activity, thiazolothiazoles have become of interest to materials science. We are aware that from a “bank” of existing compounds/procedures not all are presented in this review, and we apologise to respective groups whose research have not been objectively included.
Roamin’ Holiday: Protestants on Foot in the Eternal City
Authors: Michelson Emily
Published: May 2023

This article analyses accounts of sixteenth- and seventeenth-century Anglophone travellers to Rome who encountered and described Catholic rituals of walking. These visitors observed Catholic rituals such as pilgrimages and processions so closely that they came to understand the act of walking and ways of walking as expressions of religious identity. They also used the language of walking to interpret such moments of encounter in their narratives. Taken together, this evidence demonstrates the centrality of walking to their understanding of a religiously diverse Europe.
Editorial: Rethinking Catholicism in Early Modern Italy
Authors: Christopoulos John , Pirillo Diego
Published: May 2023

In 1925, having spent six months on the island of Capri, Walter Benjamin and Asja Lãcis published a short essay on the city of Naples in the Frankfurter Zeitung [...]
Oxygen Sensor-Based Respirometry and the Landscape of Microbial Testing Methods as Applicable to Food and Beverage Matrices
Authors: Papkovsky Dmitri B. , Kerry Joseph P.
Published: May 2023

The current status of microbiological testing methods for the determination of viable bacteria in complex sample matrices, such as food samples, is the focus of this review. Established methods for the enumeration of microorganisms, particularly, the ‘gold standard’ agar plating method for the determination of total aerobic viable counts (TVC), bioluminescent detection of total ATP, selective molecular methods (immunoassays, DNA/RNA amplification, sequencing) and instrumental methods (flow cytometry, Raman spectroscopy, mass spectrometry, calorimetry), are analyzed and compared with emerging oxygen sensor-based respirometry techniques. The basic principles of optical O2 sensing and respirometry and the primary materials, detection modes and assay formats employed are described. The existing platforms for bacterial cell respirometry are then described, and examples of particular assays are provided, including the use of rapid TVC tests of food samples and swabs, the toxicological screening and profiling of cells and antimicrobial sterility testing. Overall, O2 sensor-based respirometry and TVC assays have high application potential in the food industry and related areas. They detect viable bacteria via their growth and respiration; the assay is fast (time to result is 2–8 h and dependent on TVC load), operates with complex samples (crude homogenates of food samples) in a simple mix-and-measure format, has low set-up and instrumentation costs and is inexpensive and portable.
An Opposition-Based Learning Black Hole Algorithm for Localization of Mobile Sensor Network
Authors: Zheng Wei-Min , Xu Shi-Lei , Pan Jeng-Shyang , Chai Qing-Wei , Hu Pei
Published: May 2023

The mobile node location method can find unknown nodes in real time and capture the movement trajectory of unknown nodes in time, which has attracted more and more attention from researchers. Due to their advantages of simplicity and efficiency, intelligent optimization algorithms are receiving increasing attention. Compared with other algorithms, the black hole algorithm has fewer parameters and a simple structure, which is more suitable for node location in wireless sensor networks. To address the problems of weak merit-seeking ability and slow convergence of the black hole algorithm, this paper proposed an opposition-based learning black hole (OBH) algorithm and utilized it to improve the accuracy of the mobile wireless sensor network (MWSN) localization. To verify the performance of the proposed algorithm, this paper tests it on the CEC2013 test function set. The results indicate that among the several algorithms tested, the OBH algorithm performed the best. In this paper, several optimization algorithms are applied to the Monte Carlo localization algorithm, and the experimental results show that the OBH algorithm can achieve the best optimization effect in advance.
Robust Fastener Detection Based on Force and Vision Algorithms in Robotic (Un)Screwing Applications
Authors: Espinosa Peralta Paul , Ferre Manuel , Sánchez-Urán Miguel Ángel
Published: May 2023

This article addresses how to tackle one of the most demanding tasks in manufacturing and industrial maintenance sectors: using robots with a novel and robust solution to detect the fastener and its rotation in (un)screwing tasks over parallel surfaces with respect to the tool. To this end, the vision system is based on an industrial camera with a dynamic exposure time, a tunable liquid crystal lens (TLCL), and active near-infrared reflectance (NIR) illumination. Its camera parameters, combined with a fixed value of working distance (WD) and variable or constant field of view (FOV), make it possible to work with a variety of fastener sizes under several lighting conditions. This development also uses a collaborative robot with an embedded force sensor to verify the success of the fastener localization in a real test. Robust algorithms based on segmentation neural networks (SNN) and vision were developed to find the center and rotation of the hexagon fastener in a flawless condition and worn, scratched, and rusty conditions. SNNs were tested using a graphics processing unit (GPU), central processing unit (CPU), and edge devices, such as Jetson Javier Nx (JJNX), Intel Neural Compute Stick 2 (INCS2), and M.2 Accelerator with Dual Edge TPU (DETPU), with optimization parameters, such as the unsigned integer (UINT) and float (FP), to understand their performance. A virtual program logic controller (PLC) was mounted on a personal computer (PC) as the main control to process the images and save the data. Moreover, a mathematical analysis based on the international standard organization (ISO) and patents of the manual socket wrench was performed to determine the maximum error allowed. In addition, the work was substantiated using exhaustive evaluation tests, validating the tolerance errors, robotic forces for successfully completed tasks, and algorithms implemented. As a result of this work, the translation tolerances increase with higher sizes of fasteners from 0.75 for M6 to 2.50 for M24; however, the rotation decreases with the size from 5.5° for M6 to 3.5° for M24. The proposed methodology is a robust solution to tackle outliers contours and fake vertices produced by distorted masks present in non-constant illumination; it can reach an average accuracy to detect the vertices of 99.86% and the center of 100%, also, the time consumed by the SNN and the proposed algorithms is 73.91 ms on an Intel Core I9 CPU. This work is an interesting contribution to industrial robotics and improves current applications.