bluuebunny/crossref_metadata_2025 huggingface dataset:
Social Network Analysis of Twitter Users on BTS Topic Using Degree Centrality, Betweenness Centrality, and Closeness Centrality
Authors: Adniati Siti , Irwansyah Irwansyah , Awanis Zata Yumni
Published: May 2024

AbstractNowadays, a trademark is starting to be built through content on social media by involving influencers whose roles are increasingly needed in digital marketing. Hence, finding them on social media networks is an important thing. In brand recognition, BTS has a great influence where a brand they collaborate with gets an enthusiastic response from fans who participate in disseminating information and recommending it to others via Twitter. Therefore, this study aims to identify the potential influencer on the delivery of information on the topic of BTS on Twitter using social network analysis. Social network analysis applies the concept of graph theory where the potential influencer which is denoted by the central vertex is measured by measures of centrality, namely degree centrality, betweenness centrality, and closeness centrality. The result of the network consists of 649 vertices and 730 directed edges that form a disconnected and directed network with 67 weakly connected components. This study indicates that the influencers in the network can be fan accounts or fanbase accounts.Keywords: BTS; centrality; central vertex; influencer; social network analysis; Twitter. AbstrakDewasa ini, suatu merek dagang mulai dibangun  melalui konten di media sosial dengan melibatkan pemengaruh yang perannya semakin dibutuhkan pada pemasaran digital sehingga menemukan mereka di jaringan media sosial adalah suatu hal yang penting. Dalam pengenalan merek, BTS memberikan pengaruh yang besar dimana suatu merek yang berkolaborasi dengan mereka mendapat respon antusias dari penggemar yang ikut menyebarluaskan informasi dan merekomendasikannya kepada orang lain melalui Twitter. Oleh karena itu, penelitian ini bertujuan untuk mengidentifikasi pemengaruh potensial dalam penyampaian informasi pada topik BTS di Twitter menggunakan analisis jaringan sosial. Analisis jaringan sosial menerapkan konsep teori graf dimana simpul sentral diukur dengan ukuran sentralitas, yaitu sentralitas derajat, sentralitas keantaraan, dan sentralitas kedekatan. Diperoleh jaringan dengan 649 simpul dan 730 sisi berarah yang membentuk jaringan berarah tak terhubung yang terdiri atas 67 komponen terhubung lemah. Adapun hasil dari penelitian ini menunjukkan bahwa simpul sentral atau pemengaruh dalam jaringan dapat berupa akun personal dari pengemar (fan account) atau akun basis penggemar (fanbase).Kata Kunci: analisis jaringan  sosial, BTS,  pemengaruh , sentralitas, simpul sentral, Twitter. 2020MSC: 05C90, 91D30.
Efikasi Asap Cair Dari Kayu Mundu (Garcinia dulcis) Terhadap Penghambatan Pertumbuhan Jamur Aspergillus niger dan Aspergillus fumigatus
Authors: Wardoyo Elvi Rusmiyanto Pancaning , Kurniatuhadi Rikhsan
Published: May 2024

AbstrakAspergillus merupakan genus jamur patogen yang menyerang pasca panen hasil tanaman hortikultura, seperti jagung dan kacang-kacangan. Pemanfaatan asap cair untuk mengendalikan pertumbuhan jamur patogen saat pasca panen merupakan salah satu alternatif yang alami dan aman untuk diterapkan. Tujuan penelitian ini adalah untuk menentukan kemampuan daya hambat dan kategori aktivitas antifungi asap cair berbahan dasar kayu mundu (Garcinia dulcis) terhadap jamur Aspergillus niger dan Aspergillus fumigatus serta kandungan senyawa kimianya. Kayu mundu yang digunakan berasal dari Kabupaten Kubu Raya. Media Potato Dextrose Agar (PDA) digunakan untuk uji aktivitas antifungi asap cair. Enam konsentrasi asap cair yaitu 0; 0,5; 1,0; 1,5, 2,0 dan 2,5% digunakan untuk uji dengan dithane M45 sebagai pembanding. Hasil penelitian menunjukkan bahwa asap cair berbahan dasar kayu mundu mampu menekan pertumbuhan jamur A. niger dan A. fumigatus secara signifikan (P <0,05). Konsentrasi asap cair berbahan dasar kayu mundu sebesar 2,5% memberikan hasil terbaik dengan nilai rata-rata penghambatan terhadap jamur A. niger dan A. fumigatus masing-masing sebesar 100 dan 91,81% dan tergolong kategori aktivitas sangat kuat. Uji kandungan senyawa kimia asap cair berbahan dasar kayu mundu mengandung 5 senyawa utama, yaitu 2-propanone, 1,2 ethanediol, acetid acid, phenol 2-methoxy-4-(2-propenyl)-(CAS) eugenol, dan 3-furaldehyde. Asap cair berbahan dasar kayu mundu berpotensi untuk dikembangkan sebagai pengendali serangan jamur patogen A. niger dan A. fumigatus pada pasca panen tanaman hortikultura.AbstractAspergillus is pathogenic fungi that infect post-harvest yields of horticultural crops, i.e., Zea mays and legum. Using liquid smoke is one of the natural and safe alternatives to control fungus and the growth of pathogenic fungi that attack post-harvest yields of cultivated plants. This study aimed to evaluate the antifungal properties of liquid smoke from mundu (Garcinia dulcis) wood against the fungus Aspergillus niger and Aspergillus fumigatus. Mundu wood is from Kubu Raya Regency. The Agar media used was Potato Dextrin Agar (PDA), and concentrations of liquid smoke were 0; 0.5; 1.0; 1.5; 2.0; and 2.5%. The results indicated that the liquid smoke from Mundu wood significantly inhibited the A. niger and A. fumigatus growth (P <0.05). The highest result of liquid smoke from Mundu wood against A. niger and A. fumigatus is a concentration of 2.5% with an average inhibition value of 100 and 91.81%, respectively, with a firm activity level. The contents of liquid smoke contained five dominant compounds, i.e., 2-propanone, 1,2 ethanediol, acetic acid, phenol 2-methoxy-4-(2-propenyl)-(CAS) eugenol, and 3-furaldehyde. Liquid smoke produced from mundu wood has the potential to be developed for the control of pathogenic fungi A. niger and A. fumigatus in post-harvest horticultural crops.
Isolation And Characterization of Bacteria from Shallots (Allium cepa L.) as In-vitro Biocontrol Agent of Fusarium oxysporum f.sp cepae
Authors: Radiastuti Nani , Amalia Wuliani , Suryadi Yadi , Susilowati Dwi N , Kosasih Jajang
Published: May 2024

AbstractShallot is one of the leading vegetable commodities with many benefits such as for seasonings and herbal medicinal ingredients. The demand for shallots continues to increase; however, shallot production is still relatively low. One of the limiting factors causing low shallot production is due to wilt disease caused by Fusarium oxysporum f.sp cepae (Foc). Bacteria have many roles in suppressing the growth of Foc, and this study aims to obtain potential bacterial isolates from the shallot plant to inhibit the growth of Foc Based on fungal diameter zone inhibition, degree of inhibition, and chitinase test, it was obtained 9 isolates which could suppress the growth of Foc. The results indicated that the AB3, TB2, and UB1 bacterial isolates could inhibit the growth of Foc with a percentage of inhibition of 46.80; 40.24; and 35.11%, respectively. The analysis showed that AB3, TB2, and UB1 isolates were categorized as moderate in suppressing the growth of Foc. The 16S rRNA sequencing results showed that AB3 and TB2 isolate had similarities with Bacillus subtilis by 99,75%, and 100%, respectively, while UB1 isolate had similarities with Pseudomonas nitroreducens by 89,35%. Based on the result showed that Bacillus sp. AB3 and TB2 isolates, and P. nitroreducens UB1 isolate have more potential as biological control agents to control the Fusarium wilt at in vitro assay. The field efficacy studies on these potential antagonists need to be done in the future.AbstrakSalah satu faktor pembatas yang menyebabkan rendahnya produksi bawang merah adalah penyakit layu yang disebabkan oleh Fusarium oxysporum f.sp cepae (Foc). Bakteri antagonis memiliki banyak peran dalam menekan pertumbuhan Foc, dan penelitian ini bertujuan untuk mendapatkan isolat bakteri antagonis potensial asal tanaman bawang merah untuk menghambat pertumbuhan Foc. Berdasarkan nilai zona hambat diameter jamur, derajat hambat dan uji kitinase, diperoleh 9 isolat yang dapat menekan pertumbuhan Foc. Hasil penelitian menunjukkan bahwa isolat bakteri AB3, TB2, dan UB1 mampu menghambat pertumbuhan Foc dengan persentase penghambatan masing-masing sebesar 46,80; 40,24; dan 35,11% dengan kategori penghambatan pertumbuhan Foc moderat. Hasil sekuensing 16S rRNA, menunjukkan bahwa isolat AB3 dan TB2 memiliki kemiripan dengan Bacillus subtilis masing-masing sebesar 99,75%, dan 100%, sedangkan isolat UB1 memiliki kemiripan dengan Pseudomonas nitroreducens sebesar 89,35%. Berdasarkan hasil penelitian menunjukkan bahwa Bacillus sp. isolat AB3, TB2, dan P.nitroreducens isolat UB1 berpotensi digunakan sebagai agen pengendali hayati untuk mengendalikan penyakit layu Fusarium pada uji in vitro. Studi kemanjuran lapangan terhadap isolat antagonis potensial ini perlu dilakukan di masa depan.
A felszín alatti hidrogéntárolás kőzetalkotó ásványokra gyakorolt hatása a Pannon-medencében
Authors: Gelencsér Orsolya , Tóth Péter , Németh Tibor , Szabó-Krausz Zsuzsanna , Falus György
Published: May 2024

Összefoglalás.

Az energiaigény és a megújuló energiaforrásokból származó kínálat között fennálló
szezonális eltérés áthidalható a hidrogéngáz bevezetésével az energiaellátásba.
A nagy léptékű energiatárolás hidrogén formájában a felszín alatti térben
lehetséges. Azonban a kőzet pórusterében az injektált hidrogén hatására
végbemenő reakciók nemcsak a kitermelendő hidrogén mennyiségét és minőségét
csökkentik, de a kőzet hosszabb távú állékonyságát is ronthatják. A
Kárpát-Pannon régióban jelentős mennyiségben találhatók porózus kőzetek, amelyek
hidrogéntárolásra is alkalmasak lehetnek. Ugyanakkor, ezek a kőzetek változatos
ásványos összetételük miatt reakcióba léphetnek a hidrogénnel. Vizsgálatunk
célja, hogy megismerjük a kőzetalkotó ásványok viselkedését pórusvíz és hidrogén
jelenlétében, amely elengedhetetlen a rezervoár tárolási potenciáljának
felméréséhez.

Summary.

One of the key substances in the modern-day energy transition is hydrogen, which
can be utilized as an energy storage chemical substance. To store hydrogen on
the scales required for global hydrogen economy, porous geological formations
should be considered. However, geochemical challenges associated with hydrogen
storage in sedimentary formations are still not well understood. Mineral
dissolution and precipitation, as a result of hydrogen injection into the rocks
not only can decrease the quality and the quantity of the stored hydrogen but
may have an impact on the rock integrity as well. The Carpathian Pannonian
region is rich in porous rocks, which could serve as hydrogen storage sites.
However, many of them show various mineralogical compositions, which could
behave differently under high hydrogen partial pressure. The main objective of
our study is to predict geochemical reactions among rock-forming minerals, pore
water and hydrogen. For this purpose, we apply analytical techniques and
geochemical modeling.

The subject of this research is the Late Miocene Szolnok Sandstone Formation
located in the Pannonian Basin, Carpathian-Pannonian Region. In the future this
Formation can play a significant role in hydrogen storage, due to its favorable
reservoir geological and petrophysical characteristics.

X-ray diffraction analyses were carried out, polished and thin sections were
prepared for petrographic and geochemical analyses. The collected data were used
in the PHREEQC modeling environment. In the first stage, equilibrium batch
models were made to assess the potential long-term impacts of hydrogen on the
reservoir rock and the effect of the geological environment. The modeling
results of the project showed that hydrogen almost does not react with silicates
(e.g., quartz). Possible hydrogen loss can occur due to redox reactions. Pyrite
(FeS2) can react with hydrogen producing hydrogen sulfide
(H2S) and since petrography has revealed that the studied
sandstones have pyrite as accessory mineral.
A simple, rapid, and green method for determination of three cholic acids in bio-transformed Jindanfen by HPLC-MS
Authors: Qian Zhengming , Huang Qi , Wang Feng , Lei Qinggui , He Zhuobin , Wu Qilong , Wu Menghua , Gao Jin
Published: May 2024

A simple, rapid, and green high-performance liquid chromatography-mass spectrometry (HPLC-MS) method was developed for determination of tauroursodeoxycholic acid (TUDCA), taurocholic acid (TCA), and taurochenodeoxycholic acid (TCDCA) in bio-transformed Jindanfen (BTJDF), which is obtained from chicken bile through a bioconversion process. The sample was prepared using water. The HPLC separation was operated on a poroshell 120 EC-C18 column with a 2.0 min gradient elution procedure. Detection was performed on a single quadrupole mass spectrometer in negative mode with selected ion monitoring mode (SIM). This developed HPLC-MS method presented good linearity (r > 0.997) and sensitivity (limit of quantification, 30.0–80.0 pg) for three analytes. The relative standard deviations (RSDs) for precision, repeatability, and stability were all below 3.00%. The matrix effects and average recoveries of three analytes were 91.2–97.9% (RSDs < 1.50%) and 95.4–103% (RSDs < 3.00%), respectively. The average contents of TUDCA, TCA, and TCDCA in ten batches of samples were 33.8, 13.2, and 20.5%, respectively. Finally, the greenness of the developed method was validated by Analytical Eco-Scale and Complex-GAPI. The developed method was proved to be an eco-friendly, effective, and reliable approach for assaying the three cholic acids in BTJDF, which is help to improve the quality evaluation level of the BTJDF industry.
A case study on renewal strategies for industrial communities in urban fringe area
Authors: Tan Jie , Hutter Akos
Published: May 2024

In China, the decline of industrial communities suffering from both the aging of physical space and the breakdown of social relations. How to make marginalized and closed industrial communities actively integrate into the development of urban renewal has gradually become an issue of concern.

The paper takes the “Jingzhou New Town Industrial Park Urban Design Project” as an opportunity to explore a transformation path suitable for China's national conditions through the study of the history, culture, current problems, and renewal strategies of this heritage-type industrial community.

The study finally proposes three renewal strategies for industrial communities, which provide samples with certain reference value for the renewal of old industrial communities.
Integrated care: Health Promotion Hospital Model to Improve Family Support for Patients with Chronic Disease
Authors: Rina Kurniawati  , Mahendro Prasetyo Kusumo
Published: May 2024

Background:  One of the strategies to hold down such economic burden is to improve health promotion services. Family involvement can be used to increase the success in health promotion program. Family involvement in chronic disease management is associated with successful chronic disease treatment.The aim of this study is designing health promotion hospital model to improve family support for patients with chronic disease.
Method: This qualitative study was conducted through four focused group discussion (FGD) and six in-depth interview. The data were collected from June-October 2021. The analysis used in this study is Miles and Huberman qualitative data analysis. The analysis was carried out starting from data collection, data reduction, data presentation, and drawing conclusions.
Result: From the transcript of four FGDs and six interviews, a family-based health promotion model was obtained. The family-based health promotion model to increase family support for chronic disease patients in hospitals is formed from eight (8) elements, namely: 1) Health literacy, 2) The preferred method is peer-led discussion, group discussion, 3) Social media using WhatsApp Groups, 4) Forming groups involving families, 5) Involving community leaders, 6) Relaxing and entertaining activities, 7) Effective communication, and 8) Nurse engagement.
Conclusion: The health promotion hospital model to increase family support for patients with chronic diseases consists of: Supporting the patient's family to increase the patient's knowledge about the disease and how to treat it. Peer-led discussion, group discussion, and face-to-face meeting along with giving of leaflet with materials as desired by the patients and their family are the education methods preferred by the patients and their family.
Content validity and inter-rater reliability of procedural skill checklists used in the online OSCE scoring management system
Authors: Indarwati Ferika , Primanda Yanuar , Haris Fahni , Yulianti Sutrisno Resti
Published: May 2024

Introduction: The use of online Objective Structured Clinical Examination (OSCE) scoring system in medical and nursing education is emerging. To ensure valid student’ score, the OSCE check lists need to be assessed for its validity and reliability. This study aims to test the validity and reliability of several procedural check lists commonly used in nursing profession such as peripheral intravenous insertion, electrocardiogram placement, nasogastric tube insertion, urinary catheter insertion and oxygenation procedure.
Methods: The expert consensus was used to generate items, content validity index and inter-rater reliability was used to evaluate the validity and reliability of the check lists. Five experts assessed the content validity of the checklists and five raters used the check list to evaluate performance of 11 students. Data were collected from April to May 2022. The panel experts rated the content relevance of each instrument using a four-point rating scale. Item level and scale level content validity index were calculated. Inter-rater reliability was calculated using Fleiss Kappa.
Results: The item validity index for the five check lists reviewed showed relatively high content validity among experts. I-CVI for each tool was very good, ranging from 0.8 to 1. The average content agreement (S-CVI/Ave) and the universal agreement (S-CVI/UA) for each check list were also very good. The inter-rater reliability results indicated that the agreement among raters was ranged from moderate to very good/excellent. The lowest Kappa value was for the nasogastric insertion check list (0.40, 95%CI 0.40 – 0.41) and the highest Kappa value was for the oxygenation check list (1, 95% CI 0.99 – 1).
Conclusion: The face validity was reported as easy to understand and presented logically. Nonetheless, re-formatting of some items and addition of details in the checklists are needed to avoid ambiguity, which could lead to confusion for the examiner and examinee.
Spiritual care on quality of life patients exposed to COVID-19 in the city area of Semarang
Authors: Hartiti Tri , Yanto Arief
Published: May 2024

Introduction: Caring is a basic professional character that nurses must have in providing nursing care, including patients exposed to COVID-19, where nurses play an important position in maintaining their quality of life. This study aimed to find out the spiritual caring of nurses in this case is altruistic caring and humanistic caring on the quality of life of patients exposed to COVID-19 in the physical, psychological, social, and environmental dimensions.
Methods: This research was correlational using a cross-sectional approach to 118 respondents, namely patients exposed to COVID-19, both those being treated in isolation at the hospital, as well as independent isolation using the purposive sampling method. The instrument used in this study is the quality of life questionnaire which consists of 4 dimensions and a spiritual care questionnaire given by nurses.
Results: The research showed the characteristics of the sample were mostly women 83 (70.33%), the age of the respondents was at least 23 years and a maximum of 65 years, the most with undergraduate education as many as 53.38%; employment status 80.51% private employees, marital status 83.89% married; treatment status 82.20% hospitalized; length of hospitalization between 2 to 40 days with an average of 12.26 days; Most of the respondents are Muslim 95.76%. The value of altruistic caring is good (63.56%), humanistic caring is good (68.64%). The quality of life of respondents who were exposed to COVID-19 was mostly good, 66.94%.
Conclusion: There was a relationship between spiritual caring, both altruistic caring and humanistic caring, on the quality of life of patient respondents exposed to COVID-19, where the better the perception of spiritual caring the better the quality of life. This research can be used as evaluation material for nursing care providers to cultivate caring character to improve the quality of life of patients.
Relationship between knowledge and medication adherence among patients with tuberculosis: a cross-sectional survey
Authors: Muhammad Thesa Ghozali  , Cica Tri Murani
Published: May 2024

Background: The World Health Organization (WHO) stated that treatment adherence is one determinant of the successful management of pulmonary tuberculosis therapy. Non-adherence can result in recurrence or treatment failure. Knowledge of tuberculosis is crucial for a patient's adherence to treatment, and the level is proportional to the information obtained. This study aimed to determine the relationship between the knowledge level of pulmonary tuberculosis and adherence to anti-tuberculosis drugs (ATD).
Methods: This study is a non-experimental quantitative study with analytic correlation and a cross-sectional approach. Sampling was done at the Umbulharjo 1 Public Health Center, Yogyakarta, Indonesia, in November-December 2021, using purposive sampling with 43 respondents. The knowledge level and adherence were measured using a questionnaire and the Morisky Medication Adherence Scale (MMAS-8). Meanwhile, the relationship between the variables was analyzed using the Pearson Product Moment correlation test with a significance level of 95%.
Results: The results showed that respondents with high, moderate, and low knowledge levels were 88.37%, 11.63%, and 0%, respectively. Respondents with high, moderate, and low adherence to ATD were 95.34%, 4.7%, and 0%, respectively. Furthermore, analysis of the relationship to taking ATD obtained a p-value of 0.001 (<0.05) and a correlation value (r) of 0.609.
Conclusion: Most patients had high knowledge and adherence to medication, and the correlation showed a strong relationship between the variables and taking ATD.
Relationship between teeth brushing habits and tooth pain experienced in children with Autism Spectrum Disorder (ASD)
Authors: Octavia Alfini , Farani Wustha , Azzahra Syaina , Safira Meita Hapsari
Published: May 2024

Introduction: Autism Spectrum Disorder (ASD) is a lifelong developmental disorder that causes difficulty in communicating and socializing. The limitations of communication result in the inability to conduct teeth brush training and lead to poor oral health which might cause tooth decay and pain. This study aims to evaluate the relationship between teeth brushing habits and tooth pain experienced in children with ASD.
Methods: This study used an analytic observational study with a cross-sectional design. The subjects of the study were selected randomly using a cluster sampling method to children with ASD at Specialize School for Disability /Sekolah Luar Biasa (SLB); SLB Bina Anggita, SLB Citra Mulia Mandiri, SLB Dharma Rena Ring Putra II, SLB Negeri 1 Bantul, SLB Samara Bunda, and SLB Tegar Harapan. The data about teeth brushing habits and tooth pain experience were measured by a questionnaire filled out by parents and caregivers and then analyzed using SPSS ver. 23.
Results: This study involved 40 children with ASD, with 30 (75%) were boys and 10 (25%) were girls. The age range were between 6-12 years (23 children; 57.5%), and 13-18 years (17 children; 42.5%). Most children report medium pain in tooth pain (16 children; 40%). The Spearman's test showed a significant inverse correlation between the teeth cleaning habits and the tooth pain experienced (r = -0.464; p=0,003).
Conclusion: There was a significant relationship between the teeth brushing habits and the tooth pain experienced in children with ASD in Specialized schools in Yogyakarta.
Factors that determine inpatient satisfaction on nursing care: a cross-sectional study
Authors: Sulaiman  , Anggriani  , Maryaningsih  , Ronald Erwansyah  , Lagut Sutandra Siregar  , Muchti Yuda Pratama  , Selly Oktaria  , Rahmadi Ali  , Yenni Gustiani Tarigan
Published: May 2024

Background: A hospital must maintain and increase patient visits by presenting and providing quality services. This study examines factors determining inpatient satisfaction concerning nursing care at Siti Hajar General Hospital, Medan, Indonesia.
Methods: A cross-sectional descriptive study was conducted on 67 patients hospitalized at Siti Hajar General Hospital using the accidental sampling method from January to October 2018. Data were collected using a standardized questionnaire, while univariate and bivariate tests were used for data analysis. Furthermore, the SPSS version 20.0 for Windows was used for the Spearman Correlation test with a p-value <0.05 considered significant.
Results: The study showed that there were a significant correlation between nursing care in the form of attention (p=0.002), acceptance (p=0.016), communication (p=0.010), cooperation (p=0.004), and responsibilities (p=0.011) with inpatient satisfaction at Siti Hajar General Hospital.
Conclusion: Nurses must actively respond to every patient complaint and show a caring attitude. They also have to communicate with patients and families about their disease and explain all activities related to nursing care actions for adequate understanding and compliance.
Potentially acute misoprostol toxicity during third-trimester pregnancy: a case report
Authors: Riyan Hari Kurniawan  , Ni Putu Cahya
Published: May 2024

Background: The International Federation of Gynecology and Obstetrics (FIGO) recommends the dosage of misoprostol for pregnancy termination in >28 weeks is 25 mcg to 100 mcg per-vaginal or sublingual or buccal, every 6 hours, and the maximum dose is 6 mg. Acute misoprostol toxicity is rarely reported, including in the case of pregnant women. This study aims to discuss the effect of potentially acute misoprostol toxicity in pregnant women and the fetus.  
Case Presentation: A 17 years-old woman, G1, 32 weeks, presented with singleton intrauterine fetal death. The patient previously consumed 14 tabs of oral misoprostol and 4 tabs of misoprostol intravaginally. Her vital signs were within a normal level, his 4x/10'/40", and her fetal heart rhythm was negative. From vaginal touché found complete dilation. The patient led to bear down and born baby boy, demise fetal, 1965-gram, 43 cm, no maceration and placenta born completely. After delivery, the mother was in good condition. Misoprostol is a synthetic analog of prostaglandin E1, which can be used for uterotonics and cervical ripening. In pregnant women, misoprostol toxicity can induce hypertonic uterine contractions, leading to fetal distress and death, rhabdomyolysis, hyperthermia, respiratory alkalosis, hypoxemia, and metabolic acidosis. One article reported maternal death due to upper gastrointestinal bleeding and multiorgan failure. We analyze that intrauterine fetal death may happen because of excessive misoprostol that induces hypertonic uterine contraction, causing fetal distress and leading to fetal demise.
Conclusion: Excessive consumption of misoprostol or potentially acute misoprostol during the third-semester pregnancy can lead to harmful effects for both mother and fetus.
Vitamin D and cathelicidin assessment in children with pneumonia
Authors: Arief Fatimah , Setyoningrum Retno Asih , Irawan Roedi , Husada Dominicus , Utamayasa I Ketut Alit , Kahar Hartono
Published: May 2024

Introduction: Pneumonia is a lung infection that becoming one of the most causes of death in children in developing countries. A deficiency of vitamin D has been suggested in several research had a potential role in reducing cathelicidin production. It is a peptide that could act as an anti-microbial agent. Thus this research aimed to analyze the effect of vitamin D supplementation on serum cathelicidin levels.
Method: This study was a quasi-experimental, pretest-posttest control group double-blinded design conducted in the pediatric inpatient ward of General Hospital Dr. Soetomo Surabaya. The inclusion criteria of the sample were children that have been diagnosed with pneumonia clinically, and the ages must range from 1 month up to 5 years old. An oral single dose of 100,000 IU of vitamin D (cholecalciferol) has been administered to the participant, on the day of enrolment after the collection of the blood samples. Cathelicidin and calcidiol (25-hydroxyvitamin D) levels were obtained. Supplementation with oral vitamin D3 (cholecalciferol) at 100,000 IU single dose and placebo was given. At 8 days, all subjects had repeat serum cathelicidin and vitamin D levels. All of the data were annyalsis in SPSS ver 25. We analyze the data descriptively and analytically. For the analytic analysis, we analyze the data by man-witney and paired t-test.
Results: Forty-six subjects were consisting in this study consisting of 23 cases and 23 controls, 30/46 were males and 16/46 were females. The median age in the study was 24 months. The mean levels of cathelicidin in the post-supplementation treatment group were 11.80 + 11.40 with p value= 1.00. Meanwhile, the mean level of cathelicidin in the placebo group after giving the placebo was 8.81 + 6.46 with p val ue= 0.29.
Conclusion: Enhancement of vitamin D in children with pneumonia after giving the supplementation has been established. Meanwhile, only calcidiol serum level was to be significant in difference when comparing the pre and post-examination of the vitamin D supplementation group.
Effects of Lactobacillus plantarum IS-10506 on gastric protective mucosal factors: an ibuprofen-induced gastric mucosal injury
Authors: Darma Andy , Riawan Wibi , Sumitro Khadijah Rizky , Athiyyah Alpha Fardah , Ranuh Reza , Qorib Mohammad Fathul , Surono Ingrid , Sudarmo Subijanto Marto
Published: May 2024

Background: Gastric mucosal protective factor plays an important roles in gastric homeostasis between mucosal injury and mucosal repair. Previous study implicated probiotics in the repair of the intestinal mucosa, while probiotic role in gastric mucosa remains poorly understood.  This study aims to determine the role of probiotic L. plantarum IS-10506 in gastric protective mucosal factors by examining the expression of cyclooxygenase-1 (COX-1), COX-2, prostaglandin E2 (PGE2), and gastric mucus production (Mucin 5AC/ MUC5AC) by surface mucous cells as gastric mucosal protective factors.
Methods: Twenty-seven male Wistar rats (Rattus norwegicus) were divided into 3 groups, ie. control, curative and preventive group. Ibuprofen 300mg/kgBW were given to all groups to induce gastric injury, while Lactobacillus plantarum IS-10506 1x109 CFU/day were given into the curative (5 days) and preventive (12 days) groups. Antrum tissue with primary monoclonal antibodies againts COX-1, COX-2, PGE2, and MUC5AC were examined in the day -1, -3, and -5 after necropsy.
Results: Number of cells expressed COX-1, COX-2, PGE2 and MUC5AC in curative and preventive groups were significantly higher than control group. L. plantarum IS-10506 showed its efficacy in gastric mucosal repair on third day in the curative group and on first day in the preventive group. L. plantarum IS-10506 probiotic plays a role in gastric protective mucosal factors by promoting cell expression of COX-1, PGE2, and MUC5AC. In addition, it has been determined that L. plantarum IS-10506 inhibits COX-2 expression, that may lead to minimalize the inflammatory conditions and a deterioration of the gastric mucosal environment.
Conclusion: Lactobacillus plantarum IS-10506 can prevent ibuprofen-induced antral mucosal damage through gastric protective mucosal factors.
The effect of low-intensity intradialytic aerobic exercise on heart rate variability in maintenance hemodialysis patients
Authors: Dewi Dilia Ratna , Tinduh Damayanti , Andriati  , Thaha Mochammad , Mohammad Fathul Qorib  , Melaniani Soenarnatalina
Published: May 2024

Background: End-stage renal disease (ESRD) patients undergoing maintenance HD typically adopt a sedentary lifestyle which increases cardiometabolic risk and takes many years to be clinically detectable. Heart rate variability (HRV) is a non-invasive method to assess cardiac autonomic modulation. Interventions to increase HRV, such as exercise therapy, have been examined, given the theoretical plausibility that improvements in HRV may lead to improved outcomes. This study aimed at assessing the effects of aerobic exercise during hemodialysis sessions on the HRV of patients with ESRD.
Methods: This research is a quasi-experimental study with pre and post-test randomized control group design. From the total of 20 ESRD patients undergoing maintenance HD randomly assigned to either exercise or control group, 2 subjects dropped out, leaving 18 ESRD patients. The patients in the exercise group were submitted to a low intradialytic aerobic exercise, performed during the first two hours of HD, twice weekly, for 12 weeks. At baseline and after 12 weeks, all participants underwent short-(for 5 min) term measurements of HRV. The data were analyzed in the SPSS package program.
Results: There is a significant difference in post-pre changes (Δ) SDNN between the exercise and control group, but there were no significant differences in ΔRMSSD (p = 0.157) and ΔLF/HF ratio (p = 0.859), with the large effect size for ΔSDNN (Cohen’s D 1.01), medium effect size for ΔRMSSD (Cohen’s D 0.70), and very small effect size for ΔLF/HF ratio (Cohen’s D 0.09).
Conclusion: Twelve weeks of supervised low-intensity intradialytic aerobic exercise has modified heart rate variability in maintenance hemodialysis patients.
Healthy food for pregnant mother
Authors: Gde Ngurah Indraguna Pinatih
Published: May 2024

It is natural for women to be pregnant but full of risks.  Food and diet greatly influence the gestation, it can worthful supporting the pregnancy or in the opposite it can also be harmful to and destroy the mother and/or the foetus growing inside her.  Healthy diet at the time of pregnancy is very important. The amount shall meet the requirement, the composition shall be balanced and it has to be safe from anything harmful for the mother or the foetus. Some suggestions such as cooking all food consumed, consuming more fresh food rather than processed and/or canned, avoiding alcohol and cigarette smoke and also limiting salt, simple sugar and seafood are very important to be followed.
Application of group positive psychotherapy to improve psychological well-being for people with HIV in Papua
Authors: Nasrah  , Korinus Suweni  , Jems KR Maay  , Siti RM Arifin  , Abdilahi Yousuf
Published: May 2024

Introduction: Problems that arise in a person with HIV/AIDS status are related to disease conditions and psychosocial conditions that can affect psychological well-being. One form of intervention that can improve psychological well-being is Group Positive Psychotherapy. The present study aimed to investigate the effect of implementing positive group psychotherapy in improving the psychological well-being of people living with HIV/AIDS (PLWHA) in the working area of the Timika Jaya Health Center, Mimika Regency.
Method: This is a quasi-experimental research with the One Groups Pretest-Posttest Design technique approach. Respondents were pretested before the group positive psychotherapy treatment with counseling and education methods. Upon completing the treatment, a posttest was administered. The population of this study was the entire community of PLWHA in the working area of the Timika Jaya Public Health Center with 27 people for a total sampling technique. Data analysis used Chi-Square Test and Paired Samples T-Test. Based on the results of the analysis using paired sample t-test, p-value = 0.000 <α means that there is a significant difference in psychological well-being in PLWHA before and after 1 month of positive group psychotherapy intervention.
Result: Furthermore, from 1 month of group positive psychotherapy intervention to the next 2 months, p = 0.000, and before the second group positive psychotherapy intervention, p = 0.000. Overall, there was a significant difference in the improvement of psychological well-being before and after the group positive psychotherapy intervention.
Conclusion: Group positive psychotherapy effectively improves psychological well-being for people with HIV/AIDS.
Evaluation of the utilization Neutrophil-Lymphocyte Ratio (NLR) and Immature-to-Total Neutrophil (I/T) Ratio in diagnosing Late-Onset Neonatal Sepsis (LONS) in 31-36 weeks preterm neonates in Indonesia
Authors: Setyawati Ernie , Satari Hindra Irawan , Setiawaty Vivi , Amalia Pustika
Published: May 2024

Background: Late-onset neonatal sepsis (LONS) is a leading cause of death and morbidity among preterm neonates. Early diagnosis is crucial for appropriate and prompt management. A rapid, simple, and readily accessible diagnostic tool is important to diagnose LONS early. This study aims to assess the diagnostic value of the neutrophil-lymphocyte ratio (NLR) and NLR combined with the immature-to-total (I/T) ratio for diagnosing LONS.
Methods: This retrospective cross-sectional study collected data from Cipto Mangunkusumo Hospital Neonatology Division medical records from January 2018 to December 2019. Preterm neonates with 31-36 weeks of gestational age, 7-28 days of postnatal age, and clinical sepsis were eligible for this study. Enrolled neonates were classified into two groups, proven sepsis, and unproven sepsis. The NLR and I/T were taken from the medical records.
Results: From 126 subjects, 70 were proven sepsis, and 56 were unproven. Receiver operating curve analysis for NLR was calculated, and the area under the curve of NLR corresponded to 0.953. The NLR cut-off point with the highest specificity and positive predictive value (PPV) was 1.785 (78.57% sensitivity, 92.86% specificity, 93.22% PPV, and 77.61% negative predictive value). Using a cut-off point of > 0.2, the I/T ratio has 55.70% sensitivity,  83.70% specificity, 81.25% PPV, and 60.26% NPV. The NLR and I/T ratio increased the sensitivity and PPV of the I/T ratio to 90% and 84.44%, respectively.
Conclusion: The NLR with cut-off point 1.785 has good diagnostic value for LONS in 31-36 weeks preterm neonates. A combination of NLR and the I/T ratio can increase the diagnostic value of the I/T ratio.
Cervical cancer screening and prevention among female gynecologic oncologists in Indonesia
Authors: Tjokroprawiro Brahmana Askandar , Indra Yuliati  , Laila Nuranna  , Tofan Widya Utami  , Tricia Dewi Anggraeni  , Khoirunnisa Novitasari  , Renata Alya Ulhaq
Published: May 2024

Background: Cervical cancer has become a significant health problem in developing countries. We researched cervical cancer screening and prevention among all female gynecologic oncologists (FGO) registered with the Indonesian Society of Gynecologic Oncologists (INASGO).
Methods: Participant data and cervical cancer screening and prevention data were collected using an online questionnaire. A total sampling technique was conducted, and 18 of 20 FGOs responded to the survey. All data were analyzed descriptively.
Results: Fourteen FGOs (77.8%) had their first cervical screening at the age of 31-40 years old, primarily using Pap smears (77.8%) and Pap-human papillomavirus (HPV) co-testing (22.2%). Half of the included FGOs (50%) had irregular cervical cancer screening due to lack of time (66.7%), followed by forgetting (33.3%). Most FGOs preferred liquid-based cytology (77.8%) over conventional Pap smears (22.2%). Half of the FGOs preferred the HPV genotyping and half the HPV non-genotyping test. Most of the FGOs had screenings performed by female gynecologists (77.8%), male gynecologists (11.1%), and female general practitioners (5.6%). Most FGOs underwent screenings at health facilities outside their workplace (88.9%) and were funded by themselves (94.4%). Most FGOs were vaccinated with the HPV vaccine (77.8%), and most were with the quadrivalent (85.7%) over the bivalent vaccine (14.3%). All respondents were completely (three doses) vaccinated.
Conclusion: Most of the FGOs in Indonesia have been vaccinated against HPV and screened for cervical cancer, although half are still not regularly screened. The liquid-based cytology Pap smear and the quadrivalent HPV vaccine are the preferred cervical screening and prevention methods among FGOs in Indonesia
The clinicopathological characteristics of borderline ovarian tumors at Dr. Soetomo Hospital, Surabaya: a single center study
Authors: Setyo Teguh Waluyo  , Tjokroprawiro Brahmana Askandar
Published: May 2024

Background: Borderline ovarian tumors (BOT) are a subset of epithelial neoplasms histologically defined as atypical epithelial proliferation without stromal invasion. BOTs account for 10-20% of ovarian cancer cases. This study aims to know the clinical and pathological characteristics and determine the differences in these characteristics based on age classification.
Methods: A 5-year retrospective study was conducted in a single center. Information was obtained from the pathological reports of 53 patients with BOTs between 2016-2021. Statistical analysis was performed using the Student’s t-test with SPSS version 20.0 (SPSS Inc). Continuous data were analyzed using t-tests, and categorical data were tested with Chi-square or Fisher's exact test to assess differences in clinical and pathological features between the <40 years and the >40 years age groups
Results: Most of the tumor diameters were >10 cm (92.45%) and <10 cm (7.55%). For histopathological description, respectively are MBOT (69.81%), SBOT (24.53%), EBOT (3.77%), and SMBOT (1.89%). There were 29 (45.28%) cases with elevated CA125 levels, and normal levels were 24 (45.283%). Unilateral tumors were 36 (67.92%), and bilateral tumors were 17 cases (32.08%). Serous borderline Ovarian tumor histology was higher in the >40 years group than in the < 40 years group (p<0.05). There was no relationship between cancer antigen (CA) 125 levels and bilaterality, tumor size, or stage (p > 0.05). The mean CA 125 level was higher in the >40 years group (257.92± 64.35) than in the <40 years group (74.42±63.02) (p < 0.05).
Conclusion: The median age of BOT was 40 years old and the majority had a large unilateral tumor with mucinous, the most common histologic type. There was a correlation between age, SBOT histologic type, and elevated CA-125.
Overview of prolactin levels in patients with schizophrenia during antipsychotic therapy at HB. Saanin Mental Hospital Padang, Indonesia
Authors: Hasni Dita , Surya Bayu Eka , Anissa Mutiara , Anggraini Debie
Published: May 2024

Background: Schizophrenia, which affects about 0.85% of people worldwide, is the most common illness among psychotic disorders. Antipsychotic drugs have been a mainstay of schizophrenia treatment. Antipsychotics are now the most typical factor causing increased prolactin levels (hyperprolactinemia). This research aimed to determine the overview of prolactin levels in patients with schizophrenia that receive antipsychotic therapy at HB. Saanin Mental Hospital Padang.
Methods: This descriptive research included 50 patients with schizophrenia at HB. Saanin Mental Hospital Padang in July-December 2020. It was conducted using the ELISA test method to analyze prolactin levels. Data were analyzed using SPSS version 20.0 for Windows.
Results: From a total sample of 50 patients, the research subject characteristics were as follows, the mean age of the research subjects was 39.48±12.53 years old, most were male (68.0%), and the most used antipsychotics given were second-generation antipsychotics (Atypical) (64%). The prolactin level among the research subjects was 30.20 ng/mL (CI 95% 25.18-36.31). It indicates that the average prolactin level in the research subjects is higher than the normal prolactin level, which is 5-25 ng/mL. The research results showed that females have a significant higher average prolactin level than males (p<0.05). However, the use of typical, atypical, and combination antipsychotics do not show significant differences between groups (p>0.05).
Conclusion: Patients with schizophrenia at HB. Saanin Mental Hospital Padang, who became the research respondents and consumed antipsychotics, has higher prolactin levels than average.
Levels of anxiety and depression of students and responses to online learning methods during the COVID-19 pandemic
Authors: Manuaba Ida Bagus Amertha Putra , Darmayani I Gusti Ayu Sri , Sindhughosa Dwijo Anargha , Yani Made Violin Weda , Remitha Ni Putu Sri Indrani , Sasmana I Gede Aswin Parisya , Sudira Putu Gede , Supadmanaba I Gede Putu
Published: May 2024

Introduction: The COVID-19 pandemic has affected various aspects of human life, including education. Educational institutions, including medical faculty, are trying to use the online learning approach to continue teaching and learning. Although it has many advantages due to its flexibility, there are also some disadvantages. Previous studies have shown that online learning is significantly related to student psychological disorders such as stress, anxiety to depression, thereby reducing social skills and competence in medical students. This study aims to determine the level of anxiety and depression in students of the Faculty of Medicine, Universitas Udayana Medical Education Study Program, during the COVID-19 pandemic and responses to the online learning system.
Methods: This study used a cross-sectional design. The questionnaire was compiled using the Indonesian version of the Health and Anxiety Depression Scale (HADS) and distributed online. Data were analyzed using the SPSS ver.23 program by performing the chi-square test, with a p <0.05, considered statistically significant.
Results: Based on demographic characteristics, it was found that female students got more anxiety symptoms than male students (74.8% vs. 25.2%, p=0.009), and preclinical students experienced more depression than clinical students (95.2% vs. 4.8%, p=0.037). Students who experience symptoms of anxiety and depression, as well as normal, are dominated by poor learning responses (66.3% vs. 33.7%). Study programs, family income, place of residence, and semester level do not influence anxiety and depression in students.
Conclusion: The COVID-19 pandemic situation has led to poor learning responses in medical students, both those experiencing symptoms of anxiety/depression and students without symptoms (normal).
Tumour infiltrating lymphocyts (TILs) as an excellent predictive factor for neoadjuvant chemotherapy response on locally advanced rectal cancer patient
Authors: Florencia Adys  , Iwan Kristian  , Sahudi  , Rahniayu Alphania
Published: May 2024

Background: In Indonesia, 16,000 new cases of rectal cancer were found in 2020, with a mortality rate up to 50%. Most of the cases were locally advanced rectal cancer which requires neoadjuvant therapy. A predictive marker that can indicate how neoadjuvant therapy is responding is thus required, and TILs is a biomarker that has been extensively studied as a reliable predictive and prognostic marker in colorectal cancer. This study aims to determine if the response to neoadjuvant chemotherapy in locally advanced rectal cancer (LARC) patients correlated with the density of TILs.
Methods: This study was a retrospective cohort study with samples taken from rectal cancer patients who visited Dr. Soetomo General Hospital between 2017 and 2021. TILs density measurements were taken from stromal tumors on pre-NAC biopsy examination with H&E staining. Evaluation of chemotherapy response based on abdominal CT scan. The density of TILs using 45% cut-off.
Results: A total 38 samples were studied, 21 were male and 17 were female. Twenty-nine samples (86.2%) with weak TILs density showed negative chemotherapy response or progressive tumors. There is a significant correlation between the density of TILs and the chemotherapy response of the sample studied (p=0.002).
Conclusion: TILs are an excellent predictive marker for neoadjuvant chemotherapy response in LARC patients and can be examined using H&E staining method which is cheap and fast but still has predictive value.