bluuebunny/crossref_metadata_2025 huggingface dataset:
Das Erbe der Habsburgermonarchie in den Nachfolgestaaten
Authors: Harmat Ulrike
Published: January 2025

This volume on the legacy of the Habsburg Monarchy in the successor states is published as a special volume in the series “The Habsburg Monarchy 1848–1918”. 30 authors focus on the 1920s, examining continuities from the period of the Dual Monarchy in the successor states as well as ruptures. Developed outside the concept of the twelve volumes presented in the series, the focus of the special volume is on opening up perspectives based on thematic diversity. This is done on the basis of six main areas: 1. end and new beginning: from empire to republic, 2. provision for war invalids and social policy, 3. legal continuity, citizenship and political participation, 4. administration and the military between the empire and the nation state, 5. economic consequences of the fall of the Habsburg Monarchy and 6. old elites and new ideologies – societal and social change. By exploring these different thematic areas, the volume aims to further contribute to a better understanding of those states that emerged from the collapse of the Habsburg Monarchy and the legacy it left behind, while at the same time providing a basis for further research.
Process challenges of the STRASS technique to increase the electron mobility in advanced FD-SOI nMOSFETs
Authors: Milesi F. , Rodriguez Ph. , Zouknakl L. D. Mohgouk , Brunet L. , Tran N.-P. , Le V. H. , Nolot E. , Hartmann J. M. , Loup V. , Hauchecorne P. , Jourdan M. , Perrin B. , Marion T. , Saidi L. , Marchand J. , Coig M. , Lachal L. , Mazen F.
Published: January 2025

To improve the Ion/Ioff performance of transistors, it is crucial to significantly increase the charge carrier mobility in the channels of field-effect transistors. Tensile stress/strain is known to improve the electron mobility in the channels of nMOSFETs. This paper focuses on the STRASS (Strained Silicon by Top Recrystallization of Amorphized SiGe on SOI) process for introducing tensile stress into the silicon channel of the next-generation n-type Fully Depleted Silicon-On-Insulator (FD-SOI) devices. This technique is challenging, especially for very thin silicon film channels (e.g., less than 10 nm), where the controlled creation of a buried amorphous layer by ion implantation is difficult. By carefully optimizing the individual process steps of the STRASS technique, we have achieved the transfer of up to 1.6 GPa of tensile stress into the silicon of blanket SOI wafers.

Graphical abstract
Editorial
Authors: Mabbett Terry
Published: January 2025

The three articles in this issue essentially cover the entire spectrum of crop protection which is the management of weeds, insect pests and plant disease. This trio of articles is complemented with the usual good spread of news including increased scrutiny of gene-drive systems and
making high yielding rice affordable and sustainable in the Biotechnology News section. Also included in this issue is a short review of the 19th Annual Biocontrol Industry Meeting (ABIM) 2024.
Inclusion of learners with mild hearing impairments: Teachers’ views on their language, social and academic development
Authors: Molapisi Gaone , Phasha Nareadi
Published: January 2025

Inclusion of learners with mild hearing impairments in mainstream classes contributes to their language, social and academic development. These learners require adequate support from the teachers to succeed in the classroom. However, such an endeavour requires that teachers are appropriately prepared and supported. With this study we investigated teachers’ strategies for inclusion that enhance the language, social and academic development of learners with hearing impairments in mainstream classes. This was a qualitative case study. Data were collected from 2 purposefully selected female teachers at a mainstream school that admits learners with mild hearing impairments. The school is in Soweto, South Africa. Data were collected primarily through individual interviews and analysed thematically for content. Teachers held positive views about the inclusion of learners with mild hearing impairments in mainstream schools. They highlighted the use of 2 inclusive strategies, namely, repeated reading, and peer-assisted reading as strategies for facilitating inclusion. Such strategies enhance learners’ language and social development, and ultimately contribute to academic success. Furthermore, they mentioned that a shortage of facilities, a lack of support through teacher-parent collaboration and a lack of training in inclusion were hindrances to inclusion of learners with mild hearing impairments. The conclusion is that inclusive teaching strategies should be learner-centred and allow full participation for all learners. Thus, regarding the teaching of semantics, it is recommended that more emphasis is placed on listening, speaking and constant reading.
A blueprint for implementing internal financial processes in public schools
Authors: Garcer Albert , Mestry Raj , Motala Shireen
Published: January 2025

In this article we explore the experiences of principals and school governing body (SGB) members about the implementation of internal financial processes to manage school finances. To avoid the mismanagement of school funds, SGBs are compelled to design and implement internal financial processes. However, many SGB members lack the necessary expertise and inevitably depend on principals to make financial decisions or to find practical solutions to several financial problems. Using a qualitative research approach within an interpretivist paradigm and case study design, we explored the application of internal financial processes of 18 financial managers in 6 Gauteng schools. Invariably, 2 core aspects, transparency and accountability, were raised as essential components of internal control processes. The theoretical framework underpinning this study was primarily Gidden’s structuration theory which emphasises the hierarchical levels in schools. The accountability theory, aligned with Gidden’s theory, explains the necessity for individuals to justify their actions and foster a sense of accountability for decision-making. The findings reveal that, despite SGBs developing internal financial processes, they experienced challenges to effectively implement these processes. They were compelled to review strategies to bolster internal financial processes, integrating modern technology and fostering better stakeholder engagement.
Development of various aspects of primary health care in the context of national health systems of the Commonwealth of Independent States. Part 2: management of primary health care subsystems, structural elements, processes
Authors: Drapkina O. M. , Shepel R. N. , Korotkova A. V. , Naumova Yu. S. , Hagverdiyev G. O. , Shcherbinsky A. A. , Sachek M. M. , Kulkaeva G. U. , Brimkulov N. N. , Muhsinzoda G. M. , Uralieva I. R. , Ogneva E. Yu.
Published: January 2025

Based on an analytical review of information sources on the status and development of various aspects of primary health care (PHC) in the world and in selected countries, as well as international evidence-based recommendations in a series of reviews, to assess international experience and guidelines for the development of PHC in selected members of the Commonwealth of Independent States (CIS), in particular, with respect to the management aspect. To prepare the review, a database of publications, regulatory legal documents and Internet resources was used based on selected keywords and concepts related to the management of PHC and its characteristics. Priority was given to last decade materials concerning the CIS member states. The characteristics of national PHC management were identified, systematized and arranged in following sections: principles of PHC subsystems, structural elements, processes. 

The second part presents the analysis of the development of PHC management and its characteristics, including the implementation of recommendations with proven effectiveness in the CIS member states. The analysis of sources on the experience of the CIS member states in the medical examination and follow-up of patients with chronic diseases gave grounds to propose a more precise name for continuous health care in managing health throughout life — the principle of permanence.
Edifício-monumento à Independência do Brasil (1823-1923): do planejamento ao uso, operação e manutenção
Authors: Silva Marcus Vinicius Rosário da , Ornstein Sheila Walbe
Published: January 2025

O edifício-monumento é resultado de sessenta anos de esforços para edificar um marco comemorativo à Proclamação de Independência do Brasil, cujos desdobramentos mais efetivos significaram a instalação do Museu Paulista. O objetivo deste artigo é evidenciar as iniciativas dos intervenientes e anuentes para planejar, programar, projetar, construir, adequar, utilizar, operar e manter o edifício-monumento entre 1823 e 1923. Para tanto, foi realizada uma pesquisa documental a partir de série histórica da Revista do Museu Paulista e dos Anais do Museu Paulista. Como resultado, obteve-se evidências sobre importantes tomadas de decisão, como (1) a opção de uma obra arquitetônica em vez de escultórica na fase de planejamento; (2) a aplicação da razão áurea na fase de projeto; (3) custos e prazos na fase de construção; e (4) as atividades de conservação, adequação e melhorias no edifício-monumento e no seu entorno nas fases de uso, operação e manutenção. Este artigo faz parte dos estudos relativos à pesquisa de doutorado de um dos autores, que visa compreender melhor o facility management, relacionado às atividades de operação e manutenção, com potencial de ser implementado no Novo Museu do Ipiranga.
INTERFACES FORMATIVAS NO PROGRAMA RESIDÊNCIA PEDAGÓGICA COM OLHAR PARA A FORMAÇÃO DE PROFESSORES DA ÁREA DE CIÊNCIAS DA NATUREZA E SUAS TECNOLOGIAS
Authors: Siqueira Radetzke Franciele , Dallagnol Frison Marli
Published: January 2025

No presente artigo socializa-se algumas compreensões sobre as interfaces formativas que constituem o Programa Residência Pedagógica (PRP). A pesquisa é de natureza qualitativa e a produção de resultados desenvolveu-se a partir de questionário e entrevista desenvolvidos pelos participantes do PRP (Residentes, Preceptoras e Orientadoras). Os dados foram organizados a partir da Análise Textual Discursiva (ATD) e discutidos com base no referencial teórico da Teoria da Atividade e da Investigação-Formação-Ação. A construção dos resultados implicou a construção de uma espiral autorreflexiva do processo vivenciado na pesquisa. Na análise foram identificadas e problematizadas categorias iniciais relacionadas às propostas de ação docente (Prática, Profissão, Partilha, Pessoa e Público) e duas categorias intermediárias relacionadas à temática da investigação: i) Experiência; e ii) Reflexão. Tais colocações encaminham a compreensão da conceituação da espiral autorreflexiva vivenciada no processo: InvestigAção. Como categoria final, a InvestigAção é o elo que dá sustentação às relações entre as propostas da profissão docente (Ps) e da Experiência e Reflexão postas em discussão.
A TRANSFORMAÇÃO HISTÓRICA DA DIDÁTICA NO BRASIL: REFLEXÕES SOBRE O ENDIPE (1972 a 2024) E SUA RELEVÂNCIA NA FORMAÇÃO DOCENTE
Authors: Dos Santos Célio Moacir , Arantes Sad Lígia
Published: January 2025

Esta pesquisa analisa a transformação histórica da Didática, destacando eventos relevantes no Brasil, como o Encontro Nacional de Didática e Práticas de Ensino (ENDIPE), e sua importância na formação docente, com foco nos processos de ensino e aprendizagem. Fundamentada em autores como Maria Candau, Selma Garrido Pimenta e José Carlos Libâneo, a investigação aborda sua trajetória desde a institucionalização até suas reformulações recentes. Assim, a questão de investigação consiste em analisar como a trajetória da disciplina Didática no Brasil reflete seus processos de disciplinarização, institucionalização e transformação, considerando momentos significativos e meios de divulgação no campo educacional. Metodologicamente, combina análise histórica e conceitual, explorando as relações entre Didática geral, específicas e o contexto educacional brasileiro. Os resultados apontam reformulações que refletem modelos educacionais diversos, alternando entre abordagens conservadoras, tecnicistas e críticas. No Brasil, debates sobre identidade e propósitos marcam sua inserção nos cursos de formação, com desafios como visões prescritivas e desconexão com realidades socioculturais. Avanços incluem abordagens críticas, valorização da diversidade e inclusão de professores da Educação Básica. Contudo, ainda é necessário integrar melhor a Didática geral e específicas, superando simplificações para fortalecer práticas educativas transformadoras.
ANÁLISE COMPARATIVA DOS DISTÚRBIOS DE VOZE DORES CORPORAIS EM TELEOPERADORES DE EMERGÊNCIAS
Authors: Santos Cláudio da Cruz , Araújo Aliceana Ramos Romão de Menezes , Ferreira Léslie Piccolotto , Dantas Bárbara Tayná Santos Eugênio Da Silva , Andrade Wagner Teobaldo Lopes de , Lima-Silva Maria Fabiana Bonfim de
Published: January 2025

Os teleoperadores de emergência desempenham um papel crucial na sociedade, mas enfrentam desafios relacionados à saúde vocal e corporal devido às condições de trabalho. Este estudo, de caráter observacional, descritivo, analítico, transversal e quantitativo, investigou a presença de distúrbios vocais e dores corporais em 90 teleoperadores militares e não militares, utilizando questionários específicos. Os resultados revelaram maior prevalência de problemas vocais, como garganta seca e rouquidão, e dores corporais, especialmente em pescoço e ombros, entre os militares. Ambos os grupos relataram insatisfação com a qualidade vocal e baixa procura por assistência médica ou fonoaudiológica, destacando a necessidade de atenção especializada. As diferenças significativas entre os grupos foram atribuídas a fatores como carga horária, tempo de serviço e condições laborais. Conclui-se que uma abordagem interdisciplinar é essencial para prevenir e tratar distúrbios vocais e dores corporais, promovendo a saúde e a qualidade de vida desses profissionais.
Effects of different treatment of phosphogypsum on properties of cement mortar
Authors: Du Liwei , Liu Jiesheng , Zhang Zhiyu , Zhang Senlong , Duan Shixue , Zhao Chengcheng , Gong Xiaoqiang , Liu Yi
Published: January 2025

In this paper, the effects of the phosphogypsum (PG) content at 0%–50% and the calcination at 750°C, 800°C, and 850°C on the properties of cement mortar were studied. It is observed that the optimal mechanical properties of cement mortar are achieved when the PG content is 30% and calcined at a temperature of 800°C. Building upon these findings, further investigations were conducted to explore the effect of 0%–5% quicklime aging treatment combined with calcination on the properties of cement mortar. The results show that the samples prepared with PG aging with 2% lime and calcined at 800°C exhibit the best mechanical properties. In addition, it is revealed that the mechanical strength shows similar trends compared to the activation index for PG cement mortar. Physical properties tests and microstructure observation indicate that combining calcination with quicklime modification represents an effective approach to the use of PG in the field of building materials.
Diagnosis and prognosis of internal swelling reactions in Cahora Bassa dam - A case study
Authors: Custódio João , Silva António Santos , Costa Dória , Miquithaio Ângelo
Published: January 2025

In the last decades, a significant number of large concrete infrastructures with deterioration problems related to alkali-silica reaction and delayed ettringite formation have been identified worldwide. Currently, due to phenomenological and assessment complexities, it is still difficult to provide recommendations for preventing ASR damage in new structures, involving certain aggregates, as well as to perform a complete assessment of the actual condition of an affected structure and an accurate prediction of its future deterioration. This paper aims to contribute to the ongoing discussion of this topic and, therefore, presents some of the work performed on the diagnosis and prognosis of internal swelling reactions in the concrete from the Cahora Bassa dam, in Mozambique. The Cahora Bassa dam, built between 1972 and 1975, is a part of a hydroelectric scheme located on the Zambezi River. This paper includes a very brief overview of the information available on the concrete and its constituents, at the time the dam was built, and succinctly presents the analysis of some of the results obtained in the laboratory test campaign (e.g., microstructural analyses, chemical analyses, and expansion tests) performed on cores extracted from the structure, in 2017, and on the aggregate used in the dam’s concrete.
'And the Celts live beyond the Pillars of Hercules ...': Ancient Greek Awareness of the Celts and their Geographical Location
Authors: Alonso Juan Luis García
Published: January 2025

This paper analyses the first mentions of the Celts and their geographical location in ancient sources, paying special attention to Herodotus, whom it attempts to contextualise by also considering later authors, both Greek (Polybius, Diodorus Siculus and Strabo) and Roman (Pliny and
Tacitus). This analysis is set in the context of recent debates on the linguistic nature of 'Tartessian', a little-known language of SW Hispania (considered Celtic by some scholars), as well as of the discussion of different theories on the geographical location of both Proto-Celtic and historic
Celtic peoples and languages ('Celtic from the West', 'Celtic from the East', 'Celtic from the Centre'). Herodotus places the Celts in Mediterranean Gaul, the Pyrenees marking their boundary with the Iberians. However, he also mentions that they can be reached by crossing the Strait of Gibraltar
and sailing through Atlantic waters beyond the lands of the Kynesians in southwestern Iberia. The misconception of a North / South orientation of the Pyrenees in several authors is also addressed, as well as the extent to which we may or may not interpret Herodotus as having accurate geographical,
ethnographic or linguistic information.
Psychological aspects of human behavior
Authors:   Universidad Cooperativa de Colombia, Padilla Vergara Tatiana , Urzola Mestra Enrique Carlos , Hernández Hoyos David José
Published: January 2025

This class note presents the topics and units of study developed in the course “Psychological Aspects of Human Behavior.” The document briefly describes the theorists and authors that students should consider to better understand the concepts being studied, providing tools to professionals in the social sciences to comprehend the fundamental principles of human behavior (psychobiological, emotional, behavioral, and cognitive), and the practical application of some of these concepts in everyday social contexts, from a critical and competency-based educational methodology.
Análisis de los aspectos relevantes para el proceso de reclutamiento de personal
Authors:   Universidad Cooperativa de Colombia, Robayo-Botiva Olga Liliana
Published: January 2025

En la presente nota de clase se analizan los aspectos relevantes para el proceso de selección del personal y contratación. Es necesario indicar que el proceso de reclutamiento es una etapa fundamental cuando se gestionan los recursos humanos de una organización. Consiste en atraer, captar nuevos candidatos que cumplan con los requisitos necesarios para ocupar determinados puestos de trabajo. Se debe tener en cuenta que uno de los objetivos principales en el proceso de reclutamiento es identificar y vincular a los mejores profesionales disponibles en el mercado laboral y que se involucren institucionalmente con los valores y objetivos de la empresa. Al respecto, es necesario tener en cuenta que el reclutamiento estratégico implica adoptar un enfoque proactivo y planificado para atraer a los candidatos adecuados; es decir, se trata de diseñar e implementar estrategias de reclutamiento que se alineen con los objetivos estratégicos de la organización. Lo anterior implica comprender las necesidades actuales y futuras de la empresa, así como identificar las habilidades y las competencias requeridas para cada puesto. Antes de iniciar el reclutamiento es esencial realizar un análisis de los puestos de trabajo, lo cual implica identificar las responsabilidades, las tareas, las habilidades y los conocimientos necesarios para cada posición. El análisis de puesto de trabajo permite definir los perfiles que se requieren y establecer los criterios de selección. Por último, en la presente guía se hace un análisis de la planificación del recurso humano, la cual es una etapa que también es una parte crucial del proceso de reclutamiento. Consiste en anticipar las necesidades futuras del personal y desarrollar estrategias para cubrir esas demandas; esta planificación incluye identificar posibles fuentes de reclutamiento, como anuncios en medios de comunicación, búsqueda en bases de datos, redes profesionales o agencias de empleo. Por último, se hace una revisión y análisis al proceso de reclutamiento, teniendo en cuenta que es una serie de pasos que tienen como propósitos atraer y seleccionar a los candidatos más adecuados para cubrir las vacantes de una organización. La integración estratégica busca alinear el reclutamiento con los objetivos estratégicos de la empresa. El análisis de puesto de trabajo permite definir los perfiles requeridos, mientras que la planificación del recurso humano anticipa las necesidades futuras y establece las estrategias de reclutamiento adecuadas.
Atención a la diversidad y discursos sobre lecturas en Educación Superior / Attention to diversity and discourses on readings in Higher Education
Authors: Martínez Ezquerro Aurora
Published: January 2025

The educational context demands the training of teachers who respect the individual differences. Based on the need for this training, this study analyzes the knowledge that teachers in training (Master in Teaching, Spanish Language and Literature) have about attention to diversity through readings. Two previous objectives are proposed: the first investigates the memories of Secondary Education school experiences on de subject -quiz without prior knowledge-; the second -after a short training period- offers current readings and didactic proposals. To compile the information for this case study, the mixed, quantitative and interpretive methodology is applied. Their questionnaires offer the analysis over time of a population of 71 university students (10 autonomous communities) during three academic years. The data analyzed express results of the scarce reading experiences and the training deficiencies of the students; Now they compensate for these deficiencies with education in values. This situation poses the need to develop specific training to address diversity with reading itineraries.
Itinerarios híbridos para lectores modernos. Un enfoque transmediático para textos de fantasía épica / Hybrid itineraries for modern readers. A transmedia approach to epic fantasy texts
Authors: Jerez Martínez Isabel , Encabo Fernández Eduardo
Published: January 2025

The content of the following contribution focuses on epic fantasy literature and the formation of the reader in times of evanescent content. The main goal is to analyse the horizon of expectations of the reader in accordance with an era of transmedia manifestations, but which at the same time requires a social need for the hero. A hybrid reading itinerary is proposed that takes into account the different cultural demonstrations (in different media, mainly physical and audiovisual) that a text possesses and the projections that all this can have in terms of the possible creation of content. In conclusion, the need to connect reading with sensory atmospheres that transcend people is observed; likewise, the need to analyse what the user expects from the narratives that are presented to him/her; and the need to carry out a journey through the present day and tradition of epic fantasy or high fantasy, which allows us to verify archetypes or novelties in the architecture of such texts and whether digital evolution really affects their argumentative design.
Measurement of biogenic silica from plankton v2
Authors: Hu Ying-Yu , Samarasinghe Nuwanthi , V. Finkel Zoe
Published: January 2025

Here, we present a method for measuring biogenic silica from plankton. Biogenic silica is digested using a wet-alkaline method, in which 2 M sodium carbonate is used to hydrate and depolymerize amorphous silica, resulting in the production of monosilicic acid. The molybdate measurement technique is based on the method described by Shemesh et al. (1988) and follows the JGOFS protocols outlined by UNESCO (1994). To ensure the accuracy of the measurement, Celite S diatomaceous earth is used as a check standard for the recovery of biogenic silica. Our method yields a recovery rate of 85% to 90%.
Ligation sequencing V14 —single-cell transcriptomics with 5' cDNA prepared using 10XGenomics on PromethION(SQK-LSK114) v1
Authors: Liu Yun , Fang Jincheng , Sankowski Roman
Published: January 2025

This protocol describes how to carry out sequencing of cDNA from single cells using the LigationSequencing Kit V14 (SQK-LSK114). You will need to have reverse-transcribed single-cell mRNA into cDNA using the 10X Genomics Next GEM Single Cell 5' Kit (V2) before performing PCR amplification of your cDNA with custom-ordered oligos. Finally, a standard Ligation Sequencing Kit V14 library preparation is completed to prepare the cDNA ends for sequencing on a PromethION device.
Comparative analysis of different catalytic baskets for dual-bed catalytic reactor based on CFD simulations
Authors: Capała Paweł , Ruszak Monika , Czyż Zbigniew , Rudawska Anna
Published: January 2025

Catalytic baskets used to support catalyst beds can have different designs. For industrial practice, reactors with axial and radial gas flow direction through the catalyst bed are commonly used. Based on CFD simulations, the influence of the tail gas distribution in a dual-bed catalytic reactor on the linear gas flow velocity and pressure drop across the catalyst bed was analysed. CFD simulations were performed for the reactor's use in a pilot nitric acid plant for axial-radial and radial catalytic basket designs. The calculation results indicated a significant influence of the basket design on the linear gas flow velocity profile and pressure drop distribution in a dual-bed catalytic reactor. The most advantageous solution was the coaxial arrangement of the catalyst beds without separating them with a space, which can affect the reliability of the reactor. The lowest linear flow velocity and gas flow resistance values in a dual-bed catalytic reactor were obtained for the mixed axial and radial gas flow through the catalysts beds, separated only with a porous baffle.
Pencirian Interaksi antara Labetalol Hidroklorida dengan Albumin Serum Manusia dan Glikoprotein Asid-α1
Authors: Bakar Khairul Azreena , Ng Yan Hong , Nazri Muhammad Firdaus , Muhamad Hanisah Fatini , Subramaniam Tharishini , Uithayakumar Roshalini , Abdul Razar Aida Nabila , Feroz Shevin Rizal
Published: January 2025

Labetalol hidroklorida (LAH) adalah sejenis dadah antihipertensi perencat α-β yang digunakan dalam rawatan hipertensi jangka panjang. Keberkesanan dadah ini bergantung kepada pengikatannya dengan protein plasma yang mempengaruhi sifat farmakokinetiknya. Walau bagaimanapun, terdapat jurang penyelidikan dari segi profil pengikatan LAH dengan albumin serum manusia (HSA) dan glikoprotein asid-α1 (AAG), dua protein plasma manusia yang utama. Oleh itu, penyelidikan ini telah dijalankan untuk mencirikan interaksi antara LAH dengan HSA dan AAG menggunakan kaedah multispektroskopi, mikroskopi dan analisis struktur. Perubahan pada spektrum penyerapan UV protein menunjukkan berlakunya pembentukan kompleks protein–LAH. Analisis data spektroskopi pendarfluor menunjukkan bahawa interaksi protein–LAH mempunyai keafinan yang sederhana dan adalah berbalik. Namun, LAH didapati mempunyai afiniti pengikatan yang lebih tinggi dengan AAG berbanding HSA. Seterusnya, hasil analisis mikroskop daya atom menunjukkan perbezaan morfologi dan dimensi protein setelah mengikat dengan LAH. Berdasarkan analisis struktur LAH dan simulasi dok molekul, pembentukan kompleks LAH–protein melibatkan beberapa jenis ikatan intermolekul seperti ikatan hidrogen, daya hidrofobik dan pelbagai interaksi sistem-π. Hasil kajian sesaran dadah kompetitif merumuskan bahawa tapak II dan I HSA adalah tapak pengikatan primer dan sekunder bagi LAH, berpadanan dengan hasil analisis dok molekul. Maklumat daripada kajian ini boleh dimanfaatkan dalam penghasilan dadah terbitan LAH yang lebih cekap dan selamat.
Professor Vladimir Onisimovich Kler — the founder of the histology department of the Ural State Medical University
Authors: Mikhalkina Marina V.
Published: January 2025

The article is dedicated to the outstanding physician-histologist, geographer-regional historian, biologist, geologist and paleontologist, a very versatile scientist, Professor Vladimir Onisimovich Kler. He was a famous resident of Yekaterinburg (Sverdlovsk from 1924 to 1991), but at the same time left a mark on the history of Kazan, working from 1915 to 1921 as an assistant in the departments of zoology and histology at Kazan University. It was in Kazan that the first of V.O. Kler’s famous works on determining the age of fish by bones were published, and he became seriously interested in medical histology and decided to make it the main work of his life. In 1931, Prof. V.O. Kler organized the Department of Histology, Cytology, and Embryology at the Sverdlovsk Medical Institute (now the Ural Medical University), which had opened a year earlier, and headed it for 20 years. A number of brilliant works in the field of medical histology made Prof. V.O. Kler one of the leading Russian morphologists. The desire to honor the memory of Prof. V.O. Kler as an outstanding scientist, teacher, organizer of science, and at the same time a most interesting person, and to recall his contribution to the development of Russian medicine prompted the author to write this article.
Obstructive sleep apnea in patients with bradyarrhythmias
Authors: Yunyaeva Maria V. , Bulavina Irina A. , Baymukanov Azamat M. , Weissman Yulia D. , Evmenenko Artyom A. , Ilyich Ilya L. , Termosesov Sergey A.
Published: January 2025

BACKGROUND: Obstructive sleep apnea (OSA) is associated with various cardiovascular diseases, including arterial hypertension, chronic heart failure, and cardiac rhythm and conduction disorders. In some patients, preexisting bradycardia may not be directly related to OSA. Therefore, it is advisable to rule out OSA in patients referred for pacemaker implantation.
CLINICAL CASES DESCRIPTION: OSA is a common condition frequently associated with bradyarrhythmias. In some cases, treatment for such patients involves the implantation of a permanent endocardial pacemaker. Undiagnosed OSA may lead to an increased number of unnecessary pacemaker implantations, emphasizing the importance of timely diagnosis and treatment of this condition. This article presents clinical observations of seven patients with nocturnal bradyarrhythmias, which resolved following continuous positive airway pressure (CPAP) therapy.
The use of CPAP therapy contributed to the improvement of cardiovascular parameters, including the reduction in the number and duration of heart rhythm pauses. Clinically significant bradyarrhythmias were resolved in patients, allowing them to avoid surgical intervention. In the described cases, patients demonstrated a high apnea–hypopnea index (35.0–79.5 episodes per hour), a significant decrease in blood oxygen saturation (minimum up to 50%), and significant heart rhythm disturbances during the night. The initiation of CPAP therapy led to a reduction in the apnea–hypopnea index (1.9–23.1 episodes per hour), normalization of minimum oxygen saturation (80–93%), and the elimination of prolonged rhythm pauses.
CONCLUSION: The findings highlight the necessity of mandatory screening for OSA in patients with nocturnal bradyarrhythmias before planning pacemaker implantation. CPAP therapy effectively eliminates rhythm disturbances associated with sleep apnea and prevents unnecessary surgical procedures. This confirms the importance of a comprehensive approach to the diagnosis and treatment of this category of patients and the need for further large-scale studies to optimize their management tactics.
nación cubana en el discurso histórico de la república
Authors: Martínez Alemán Yaíma
Published: January 2025

La formación de la nación cubana constituye la columna vertebral del discurso histórico cubano, con un marcado carácter ideológico. El presente artículo sintetiza las posturas teóricas fundamentales en torno a dicha cuestión en el contexto republicano; fundamentalmente desde las corrientes historiográficas nacionalista y marxista que, más allá de las diferencias ideológicas, tienen un fundamento común: la defensa de la tradición patriótico-nacionalista de inspiración martiana. Este tema historiográfico medular se analiza desde temáticas específicas; entre estas, la valoración de la burguesía cubana, las corrientes de pensamiento del siglo XIX cubano, el proceso de liberación nacional y la reflexión en torno a la experiencia republicana. Este importante tema historiográfico, que no se agota en el período republicano, constituye un fundamento de la historiografía de la Revolución cubana.
Burden of diabetic peripheral neuropathy in a rural demography of India is revealed by biothesiometry: a reliable screening tool
Authors: J. Srisakthi , Annadurai Dinesh , P. Ganesh Kumar
Published: January 2025

Background: Diabetes mellitus (DM) is the most prevalent non-communicable disease in the world estimated to be 4.4% in 2030 globally. Among its complications, diabetic peripheral neuropathy (DPN) is the common disorder manifested as ‘glove and stocking sensation’ in the lower extremities. Aim to study the prevalence and to grade DPN in patients attending OPD.
Methods: Patients coming to the general surgery and plastic surgery outpatient department were selected. A total of 331 patients will be asked history by a simple questionnaire and symptoms are graded by modified neuropathy symptom score (MNSS) and clinical examination are done and graded by diabetic neuropathy examination (DNE) and vibration perception threshold (VPT) is measured by biothesiometry.
Results: Among the DPN patients, 57.40% are asymptomatic and 12.08% are having severe symptoms by MNDS score and about 27.49% having increased risk for pronation for foot ulcer by DNE score and about 43.2% having risk for foot ulcer by biothesiometry average from the most common site for loss of sensation involving over 1st, 3rd, 5th metatarsal head to the least involved site as midfoot.
Conclusions: This study reveals the impact of DPN in a rural area, so by implementing this type of screening method reduces the development of foot ulcers by about 60% in asymptomatic patients and leg amputations by 85% in patients with severe stage of DPN with proper foot care.
Exploring the relationship between coagulation profiles and histopathological diagnosis of breast lumps: a case control study from Vindhya region, India
Authors: Rajpoot Parul S. , Agrawal Priyanka , Sutrakar Suresh K. , Tripathi Lokesh , Shambhavi
Published: January 2025

Background: Breast cancer is the most common cancer among women in India. The country is on the verge of a potential breast cancer epidemic in the coming decade, driven by lifestyle changes such as delayed marriage and childbirth, influenced by Western trends. Hypercoagulable state is one of the adverse complication seen in cases of breast cancer, according to recent study. Therefore, the purpose of this study was to evaluate the coagulation anomalies in breast cancer patients.
Methods: The study was a prospective, case control study carried out with patients presenting with complaints of lump in the breast which were confirmed to be malignant by histopathological examination.
Results: Values of PT and aPTT were found to be comparable in patients with breast cancer when compared with controls. D-Dimers were found to be significantly elevated in patients with breast cancer when compared with controls. D-Dimers were also elevated in cases with high histological grade of cancer and lymphovascular invasion.
Conclusions: Elevated levels of plasma D-dimer may offer some insight for the diagnosis breast lump.
Acute appendicitis and secondary peritonitis in a patient with end-stage renal failure and a dormant peritoneal dialysis catheter
Authors: Olang Catherine , Kiarie Patrick , Bhatia Shubham , Fultz Oliver , Louis Martine A.
Published: January 2025

Peritoneal dialysis (PD) is a common renal replacement therapy for patients with end-stage renal disease (ESRD). Despite its benefits, PD-related peritonitis remains a severe complication, often associated with significant morbidity and mortality. Although most cases of PD-related peritonitis are due to touch contamination, intra-abdominal infections, such as appendicitis, are less common but can result in severe outcomes. We present a case of severe peritonitis secondary to perforated appendicitis in a patient with a dormant PD catheter. A 41-year-old male with ESRD, previously on PD, presented with a 36-hour history of fever, chills, nausea, and abdominal pain. Despite transitioning to hemodialysis, the patient had retained his PD catheter, which had not been used for months. On admission, the patient was septic with evidence of peritonitis. Blood cultures were positive for Escherichia coli, while PD catheter cultures were negative. An abdominal CT scan revealed a gangrenous perforated appendix. The patient underwent an emergency laparoscopic appendectomy and PD catheter removal, resulting in significant clinical improvement. Perforated appendicitis in ESRD patients with a PD catheter can result in severe peritonitis with life-threatening complications, including sepsis and cardiac events. This case underscores the importance of maintaining a high index of suspicion for intra-abdominal causes of peritonitis in PD patients, even when the PD catheter is dormant. Timely diagnosis, empiric antibiotic therapy, and prompt surgical management are essential to reduce mortality in these patients.
Sleeve gastrectomy in a patient with situs inversus totalis: a case report
Authors: Almonla Yaser M. , Abduljawad Salim M. , Khazna Miyad S. , Maghmoumeh Rateb R.
Published: January 2025

The following is a case report of a 20-year-old female patient with morbid obesity and situs inversus totalis (SIT) who successfully underwent laparoscopic sleeve gastrectomy. Situs inversus (SIT) is a rare condition in which the organs are situated on the opposite side of their normal positions; it has some peculiarities during the surgery. Attention to detail in preparations before the surgery as well as modifications in the operating room allowed for the completion of the surgery in this case despite the numerous challenges. This report will show how the surgical plan was implemented in this clinical case, focusing on the intra-operative techniques and the post-operative course underscoring the flexibility of surgical treatment in such an anatomically complex case.
When benign turns aggressive: renal angiomyolipoma with renal vein invasion
Authors: Zorilla Ricardo Cervantes , Anceno Alec , Noyola Gerardo Fernández , Varela Gómez Fernando Fernández , Ascencio Martínez Marco A. , Silva Mendoza César A. , Venegas Yáñez César E. , Magdaleno-Rodríguez Daniel Roberto , Alvarado Bahena Pedro A. , Vázquez Gonzalez Juan C. , Lerma Landeros Jésus E. , Morales Montor Jorge G. , Martínez Arroyo Carlos , Cantellano Orozco Mauricio , Pacheco Gahbler Carlos
Published: January 2025

Angiomyolipoma (AML) is the most common benign kidney tumor, made up of fat, smooth muscle, and abnormal blood vessels. It represents 0.3-3% of kidney tumors and is more common in women. AMLs are typically diagnosed via computed tomography (CT) or magnetic resonance imaging (MRI), with most being asymptomatic and requiring no treatment. However, larger or symptomatic AMLs can cause hematuria, flank pain, or bleeding, necessitating treatments like selective arterial embolization, partial nephrectomy, or active surveillance. Recent studies question the traditional 4 cm intervention threshold, suggesting that larger AMLs may be safely monitored based on individual risk factors. This case report discusses a 47-year-old woman with a 4.1×2.1 cm AML with renal vein invasion, treated successfully with laparoscopic nephrectomy. The findings highlight the need for personalized treatment strategies considering tumor characteristics and patient factors, and emphasize the importance of ongoing renal function monitoring.
A case report of zoledronic acid-induced bilateral conjunctivitis
Authors: K. Aishwaraya , K. Suresh , R. Saravanan , M. Kannan
Published: January 2025

Zoledronic acid is used to treat patients with osteoporosis, Paget’s disease, multiple myeloma, and several bone tumors. This is to report a case of a patient with cervical spondylosis with periorbital swelling, watering, diminution of vision, and redness in both eyes after zoledronate infusion. The patient had lid edema and conjunctival congestion in both eyes. Symptoms resolved after 10 days of fluorometholone eye drops. Bilateral conjunctivitis is a rare complication of zoledronic acid. Zoledronic acid causes T-cell activation leading to the release of cytokines and inflammatory mediators. Orbital inflammation, scleritis, and acute anterior uveitis have also been reported as side effects of zoledronic acid.
Chronic retroperitoneal hematoma with femoral neuropathy in a case of factor-II deficiency: an interesting case report
Authors: Kumar I. Saravana , Purushothaman Selvaganesan M.
Published: January 2025

Chronic expanding hematoma is a rare condition that develops following surgery, trauma, or injury. It can occur in the retroperitoneal region after minor trauma, potentially leading to femoral neuropathy. In this case report, we present a 22-year-old male who experienced a trivial trauma during childhood, resulting in a right retroperitoneal swelling. Clinical examination revealed a swelling measuring 18×16 cm over the right lumbar and right iliac regions, which was mobile and non-tender. Central nervous system examination showed muscle atrophy in the right thigh, an absent right knee reflex, and a complete loss of sensation in the left thigh in the L2, L3, and L4 dermatomes, corresponding to femoral and obturator nerve territories. Given the patient's history of recurrent epistaxis during childhood, coagulopathy was suspected. Investigations revealed an altered coagulation profile, and the patient was diagnosed with factor II deficiency. Contrast-enhanced computed tomography (CECT) of the abdomen and pelvis and magnetic resonance imaging (MRI) with pelvic contrast suggested differential diagnoses of chronic hematoma and soft tissue sarcoma. The diagnosis was confirmed through ultrasound (US)-guided fine-needle aspiration cytology (FNAC) of the lesion. The patient underwent retroperitoneal hematoma evacuation under general anesthesia. Intraoperative findings revealed a cavity measuring 15×10 cm in the extraperitoneal plane, bordered laterally by the iliac wing, medially by a thickened peritoneal sheath, extending inferiorly to the true pelvic brim, and superiorly to the lower border of the right kidney. Postoperative recurrent bleeding was managed with fresh frozen plasma (FFP) transfusions based on a calculated formula and daily on-demand therapy. Radiological imaging confirmed complete resolution of the hematoma post-operatively. We conclude that early surgical evacuation of chronic hematomas is critical to prevent complications such as femoral neuropathy. In this patient, delayed intervention resulted in persistent femoral nerve weakness and loss of power in the affected nerve territory.
Pattern of abnormal uterine bleeding in a tertiary care hospital
Authors: Sharma Shuchi , Das Jayita , Chopal Sharab
Published: January 2025

Background: Abnormal uterine bleeding (AUB) is a significant clinical entity. Aim of the study was to observe the pattern of AUB   in tertiary care hospital.
Methods: All patients attending gynae OPD and ward presenting with AUB were included in the study.
Results: A total 640 women had AUB in one year of study period. Highest incidence of AUB is observed in the age group 40-49 years. The most common clinical presentation of AUB was metrorrhagia followed by polymenorrhoea, menorrhagia, menometrorrhagia, oligomenorrhoea and hypomenorrhoea. On ultrasonography the commonest finding was leiomyoma uterus (28.15%) followed by increased endometrial thickness (18.46%). The most common histological pattern was proliferative endometrium (34.10%). According to PALM-COEIN classification the maximum incidence found was of AUB-L followed by AUB-O.
Conclusions: The prevalent causes of AUB vary with age. So, all the patients presenting with AUB to gynaecology departments were included in the study irrespective of age. The information presented in this study adds to our understanding of patterns of the AUB.
The effectiveness of nurse-led visual rehabilitation on visual outcome among post-operative patients of sellar/suprasellar tumours-protocol of a randomized controlled trial
Authors: Bharti  , Dhandapani Manju , Salunke Parveen , Bansal Reema , Sukheja Jaspreet , Dhandapani Sivashanmugam
Published: January 2025

Background: Tumour or mass of the suprasellar region are common pathologies and are also important due to their adjacency to the vital anterior visual apparatus. They may cause serious ocular signs and symptoms in addition to neurological complications resulting from increased intracranial pressure, cranial nerve impairment, or brain compression. Increased ICP may lead to headache, double vision and loss of peripheral vision, can lead to sinus pain or ear pain, drooping eyelid and seizures. After surgery, patients may continue to experience neuropsychological symptoms, physical symptoms and develop complications.
Methods: Randomized controlled trial. A computer random table with allocation concealment will be used to recruit and assign patients with visual complaints resulting from sellar/suprasellar tumors operated on at PGIMER to the experimental and control groups. Enrolment will be done on 5th to 7th day of surgery and intervention will be provided on the same day until discharge and booklet with nurse-led visual rehabilitation will be provided for continuous practice at home. The post-op follow-up will be done at 1 month and 3rd month of surgery.
Conclusions: This aim of the study is to determine the effectiveness of “nurse-led visual rehabilitation” on visual outcome among post-op patient with sellar/suprasellar tumours at 1 month and 3 months. The comprehensive nurse-led visual rehabilitation will be designed with the inputs from all nursing and clinical specialist in neurosurgery and ophthalmology, has the ability to work well with the dynamic care of postoperative patients experiencing visual problems from suprasellar and sellar tumors.
CTRI registration number: CTRI/2023/08/056030 ON 2/8/23