bluuebunny/crossref_metadata_2025 huggingface dataset:
A Novel Fractional-Order Memristive Chaotic Circuit with Coexisting Double-Layout Four-Scroll Attractors and Its Application in Visually Meaningful Image Encryption
Authors: Wu Yuebo , Wang Duansong , Zhang Tan , Zhang Jinzhong , Zhou Jian
Published: July 2023

This paper proposes a fractional-order chaotic system using a tri-stable locally active memristor. The characteristics of the memristor, dynamic mechanism of oscillation, and behaviors of the proposed system were analyzed, and then a visually meaningful image encryption scheme was designed based on the chaotic system, DNA encoding, and integer wavelet transform (IWT). Firstly, the mathematical model of the memristor was designed, which was nonvolatile, locally active, and tri-stable. Secondly, the stability, dynamic mechanism of oscillation, bifurcation behaviors, and complexity of the fractional-order memristive chaotic system were investigated and the conditions of stability were obtained. Thirdly, the largest Lyapunov exponent, bifurcation diagram, and complexity of the novel system were calculated and the coexisting bifurcation, coexisting attractors, spectral entropy, and so on are shown. Finally, a visually meaningful image encryption scheme based on the proposed system was designed, and its security was assessed by statistical analysis and different attacks. Numerical simulation demonstrated the effectiveness of the theoretical analysis and high security of the proposed image encryption scheme.
There Is No Relation between Epitympanic Recess Volume and Chronic Otitis Media
Authors: Gokharman Fatma Dilek , Kocak Omer , Irgul Baris , Kosar Pinar , Aydin Sonay
Published: July 2023

Background: Chronic otitis media is recurrent infection of the middle ear and mastoid air cells in the setting of perforation of the tympanic membrane. Risk factors for chronic otitis media include predisposing characteristics such as gender, allergies, Eustachian tube dysfunction, history of acute otitis media, and upper respiratory tract infection. The purpose of this study was to evaluate the potential relationship between chronic otitis media and epitympanic recess volume. Materials and Methods: A total of 197 patients with chronic otitis media had their epitympanic recess volume compared to the epitympanic volume of 99 healthy controls. The epitympanic recess volume was measured via the 3D volumetric measurement tool of the local PACS. Epitympanic recess volume measurement was performed using axial sections in a plane starting from the level of the malleus head–anvil body in the craniocaudal direction to the tegmen tympanum. Results: It was shown that patients with bilateral involvement had an epitympanic recess volume of 75.00 mm3, compared to 72.30 mm3 in those with unilateral chronic otitis media. The healthy control group’s median value for the epitympanic recess was 74.73 mm3. Conclusions: Epitympanic volume values did not differ substantially between patients with chronic otitis media and healthy persons, and epitympanic volume was not recognized as a predisposing factor (p = 0.686).
Comprehensive Analysis of lncRNA–mRNA Expression Profiles in Depression-like Responses of Mice Related to Polystyrene Nanoparticle Exposure
Authors: Liu Qingping , Hu Wentao , Zhang Yaling , Ning Jie , Pang Yaxian , Hu Huaifang , Chen Meiyu , Wu Mengqi , Wang Mengruo , Yang Peihao , Bao Lei , Niu Yujie , Zhang Rong
Published: July 2023

Plastics in the environment can break down into nanoplastics (NPs), which pose a potential threat to public health. Studies have shown that the nervous system constitutes a significant target for nanoplastics. However, the potential mechanism behind nanoplastics’ neurotoxicity remains unknown. This study aimed to investigate the role of lncRNA in the depressive-like responses induced by exposure to 25 nm polystyrene nanoplastics (PS NPs). Forty mice were divided into four groups administered doses of 0, 10, 25, and 50 mg/kg via gavage for 6 months. After conducting behavioral tests, RNA sequencing was used to detect changes in mRNAs, miRNAs, and lncRNAs in the prefrontal cortex of the mice in the 0 and 50 mg/kg PS NPs groups. The results revealed that mice exposed to chronic PS NPs developed depressive-like responses in a dose-dependent manner. It was demonstrated that 987 mRNAs, 29 miRNAs, and 116 lncRNAs were significantly different between the two groups. Then, a competing endogenous RNA (ceRNA) network containing 6 lncRNAs, 18 miRNAs, and 750 mRNAs was constructed. Enrichment results suggested that PS NPs may contribute to the onset of depression-like responses through the activation of axon guidance, neurotrophin-signaling pathways, and dopaminergic synapses. This study provided evidence of the molecular relationship between PS NPs and depression-like responses.
Ciguatera Fish Poisoning in the Caribbean Sea and Atlantic Ocean: Reconciling the Multiplicity of Ciguatoxins and Analytical Chemistry Approach for Public Health Safety
Authors: Pottier Ivannah , Lewis Richard J. , Vernoux Jean-Paul
Published: July 2023

Ciguatera is a major circumtropical poisoning caused by the consumption of marine fish and invertebrates contaminated with ciguatoxins (CTXs): neurotoxins produced by endemic and benthic dinoflagellates which are biotransformed in the fish food-web. We provide a history of ciguatera research conducted over the past 70 years on ciguatoxins from the Pacific Ocean (P-CTXs) and Caribbean Sea (C-CTXs) and describe their main chemical, biochemical, and toxicological properties. Currently, there is no official method for the extraction and quantification of ciguatoxins, regardless their origin, mainly due to limited CTX-certified reference materials. In this review, the extraction and purification procedures of C-CTXs are investigated, considering specific objectives such as isolating reference materials, analysing fish toxin profiles, or ensuring food safety control. Certain in vitro assays may provide sufficient sensitivity to detect C-CTXs at sub-ppb levels in fish, but they do not allow for individual identification of CTXs. Recent advances in analysis using liquid chromatography coupled with low- or high-resolution mass spectrometry provide new opportunities to identify known C-CTXs, to gain structural insights into new analogues, and to quantify C-CTXs. Together, these methods reveal that ciguatera arises from a multiplicity of CTXs, although one major form (C-CTX-1) seems to dominate. However, questions arise regarding the abundance and instability of certain C-CTXs, which are further complicated by the wide array of CTX-producing dinoflagellates and fish vectors. Further research is needed to assess the toxic potential of the new C-CTX and their role in ciguatera fish poisoning. With the identification of C-CTXs in the coastal USA and Eastern Atlantic Ocean, the investigation of ciguatera fish poisoning is now a truly global effort.
Overlapping Infection by Strongyloides spp. and Cytomegalovirus in the Immunocompromised Host: A Comprehensive Review of the Literature
Authors: Lupia Tommaso , Crisà Elena , Gaviraghi Alberto , Rizzello Barbara , Di Vincenzo Alessia , Carnevale-Schianca Fabrizio , Caravelli Daniela , Fizzotti Marco , Tolomeo Francesco , Vitolo Umberto , De Benedetto Ilaria , Shbaklo Nour , Cerutti Alessandro , Fenu Piero , Gregorc Vanesa , Corcione Silvia , Ghisetti Valeria , De Rosa Francesco Giuseppe
Published: July 2023

Strongyloides and cytomegalovirus co-infections are rarely reported, even though they are distinguished by high morbidity and mortality, especially in immunocompromised hosts. We narratively reviewed the literature on reported cases of Strongyloides and CMV co-infections in immunosuppressed patients. Most cases occurred in males with a median age of 47 (IQR, 37–59). Strongyloides/CMV co-infections occurred among immunocompromised hosts, especially in solid organ transplants and hematological or rheumatological diseases. Most of the patients underwent a course of steroid treatment before the diagnosis of co-infections. Other common immunomodulatory agents were tacrolimus and mycophenolate. The first clinical manifestations of co-infections were mainly gastrointestinal, followed by respiratory symptoms. CMV was, in most patients, co-infected with an isolated reactivation, although Strongyloides manifested especially as hyperinfection syndrome. Ganciclovir and ivermectin are the mainstays of CMV and Strongyloides treatment. However, the treatment mortality reported in this narrative review is around 52.4%. Interestingly secondary bacterial infections are common in CMV/Strongyloides-infected patients.
What Do You Need to Know before Studying Chagas Disease? A Beginner’s Guide
Authors: De Fuentes-Vicente José A. , Santos-Hernández Nancy G. , Ruiz-Castillejos Christian , Espinoza-Medinilla Eduardo E. , Flores-Villegas A. Laura , de Alba-Alvarado Mariana , Cabrera-Bravo Margarita , Moreno-Rodríguez Adriana , Vidal-López Dolores G.
Published: July 2023

Chagas disease is one of the most important tropical infections in the world and mainly affects poor people. The causative agent is the hemoflagellate protozoan Trypanosoma cruzi, which circulates among insect vectors and mammals throughout the Americas. A large body of research on Chagas disease has shown the complexity of this zoonosis, and controlling it remains a challenge for public health systems. Although knowledge of Chagas disease has advanced greatly, there are still many gaps, and it is necessary to continue generating basic and applied research to create more effective control strategies. The aim of this review is to provide up-to-date information on the components of Chagas disease and highlight current trends in research. We hope that this review will be a starting point for beginners and facilitate the search for more specific information.
Socio-Economic Feasibility for Implementation of Environmental Legislation along the Riparian Buffer Zones in Urban Rivers of Northern Tanzania
Authors: Mwasenga Janeth Mwile , Mjemah Ibrahimu Chikira
Published: July 2023

The development of socio-economic activities within the 60 m buffer zone has imposed change on the characteristics of rivers in northern Tanzania, subjecting rivers to collateral and irreversible damage due to their prolonged exposure to anthropic activities. Time series satellite images were classified to analyze land use/cover (LULC) changes and anthropic development along the buffer zone from 2000 to 2020. Structured questionnaires were used to identify the encroachment factors and level of compliance with alleged environmental legislation. Furthermore, focus group discussions were used to acquire information on the concurrent barriers to environmental legislation implementation. The land use/cover change along the buffer zone showed that agriculture and artificial areas had a credible increase of about 43% and 30% from 2000 to 2020, respectively. Furthermore, forest and semi-natural areas decreased by 71% from 2000 to 2020, whereas wetlands decreased by about 2% within the same timeframe. On the other hand, artificial and agricultural areas increased by 24.5% and 19.5%, respectively. Forest and semi-natural areas decreased by about 44%, whereas wetlands and water showed a flimsy increase from 2000 to 2020. This trend shows that high land use/cover changes occurred along the riparian buffer zone. The results suggest that urbanization is the main driving force for riparian buffer zone encroachment, threatening ecological well-being and water resource sustainability in urban rivers. The findings of this study are useful for advancing regional and national policies and practices for sustainable water resource management.
The Impact of Spring Festival Travel on Epidemic Spreading in China
Authors: Sun Hao-Chen , Pei Sen , Wang Lin , Sun Yuan-Yuan , Xu Xiao-Ke
Published: July 2023

The large population movement during the Spring Festival travel in China can considerably accelerate the spread of epidemics, especially after the relaxation of strict control measures against COVID-19. This study aims to assess the impact of population migration in Spring Festival holiday on epidemic spread under different scenarios. Using inter-city population movement data, we construct the population flow network during the non-holiday time as well as the Spring Festival holiday. We build a large-scale metapopulation model to simulate the epidemic spread among 371 Chinese cities. We analyze the impact of Spring Festival travel on the peak timing and peak magnitude nationally and in each city. Assuming an R0 (basic reproduction number) of 15 and the initial conditions as the reported COVID-19 infections on 17 December 2022, model simulations indicate that the Spring Festival travel can substantially increase the national peak magnitude of infection. The infection peaks arrive at most cities 1–4 days earlier as compared to those of the non-holiday time. While peak infections in certain large cities, such as Beijing and Shanghai, are decreased due to the massive migration of people to smaller cities during the pre-Spring Festival period, peak infections increase significantly in small- or medium-sized cities. For a less transmissible disease (R0 = 5), infection peaks in large cities are delayed until after the Spring Festival. Small- or medium-sized cities may experience a larger infection due to the large-scale population migration from metropolitan areas. The increased disease burden may impose considerable strain on the healthcare systems in these resource-limited areas. For a less transmissible disease, particular attention needs to be paid to outbreaks in large cities when people resume work after holidays.
‘Dual Purpose’ Surface Flow Constructed Treatment Wetlands Support Native Biodiversity in Intensified Agricultural Landscapes
Authors: Goeller Brandon C. , Sukias James P. S. , Woodward Simon J. R. , Clarkson Beverley R.
Published: July 2023

In agricultural landscapes, free-water surface flow wetlands (FWS) are constructed mainly to improve water quality; however, their contribution to biodiversity conservation is increasingly recognised. To inform biodiversity management in FWS treating agricultural runoff, we surveyed the vegetation and fauna assemblages in five established FWS in a lowland, pastoral landscape in the central North Island, New Zealand. The FWS had been established for between 3 and 19 years, planted with a restricted range of native plant species, and fenced to exclude livestock access. Larger wetlands hosted significantly more plant and mammal species. However, other than wetland size, we found few other significant relationships between wetland habitat, landscape characteristics, and measures of biodiversity (total species, proportion of native species, number of wetland specialists, or threatened species). We recorded one-hundred and thirteen plant, twenty bird, five mammal, eighty-five terrestrial invertebrates, forty-seven aquatic invertebrates, six fish, and two amphibian species inhabiting the FWS. Native species comprised 96% of the total aquatic invertebrate fauna identified. For other taxa, native flora and fauna accounted for half or less than half of all species identified: 53% terrestrial invertebrates, 50% fish, 45% birds, 32% plants, and 0% amphibian and mammal species. Few wetland specialists (aquatic or wetland-adapted) or threatened native species were detected, probably reflecting the limited range of wetland plant species in initial plantings and the difficulties native taxa face when colonising new habitat where potential reservoirs of colonist species are also depauperate or too distant. FWS support native biodiversity, but further enhancements may require active management of exotic and pest species to minimise competition or predation on native species.
Influence of Rainfall Pattern on Wetness Index for Infinite Slope Stability Analysis
Authors: Na Wooyoung , Jun Changhyun , Kim Sang Yeob
Published: July 2023

Landslides are one of the riskiest disasters combining excessive rainfall and unstable slope that a wetness index can quantify. The wetness index generated by water infiltration considering the rainfall pattern such as cumulated rainfall, rainfall duration and rainfall intensity should be estimated for the slope stability analysis. Even though the infiltration capacity of soils has been largely focused to evaluate the slope stability, the temporal patterns of rainfall have commonly been ignored or assumed as a steady state for the prediction of the slope failure in the previous studies. Thus, this study focuses more on evaluating the influence of various rainfall patterns on the slope stability, and compares it with an actual landslide incident that occurred in 2011, in Korea. The factor of safety (FS) considering the time-dependent wetness index variation is used to determine the slope stability. For the various rainfall designs, the uniform rainfall distribution, Yen and Chow, Mononobe, alternating block and second quartile Huff models are adopted. Thereafter, the FS variations from five models are compared with an actual landslide incident in Seoul, Korea. Among the rainfall designs, the models that consider the abrupt rainfall intensity capture the landslide time with an FS < 1. Therefore, the appropriate adoption of a rainfall distribution model should be highlighted for landslide prediction.
Increasing Awareness of the Human Papillomavirus (HPV) Vaccine for Women 18–45 Years of Age
Authors: Cernasev Alina , Yoby Alexandria Grace , Hagemann Tracy
Published: July 2023

The human papillomavirus (HPV) vaccine prevents cancer and is highly effective; however, the uptake has been low in the United States of America (USA) and among the most vulnerable populations. A recent Center for Disease Control (CDC) report highlighted that approximately 13,000 new cases of cervical cancer are diagnosed each year in the USA. Although cervical cancer is considered treatable, especially when detected early, in the USA, approximately 4000 women die every year of cervical cancer. However, little is known about access and awareness among women in the USA. The objective of this article is to focus on the role played by clinical pharmacists in bringing awareness about the HPV vaccine. It offers recommendations to enhance the administration of the HPV vaccine. This rapid literature review revealed two significant themes: Disparities in healthcare access to the HPV vaccine among women and clinical roles in empowering women to access the HPV vaccine. This rapid review emphasizes the need for future research in enhancing awareness about HPV as a viable strategy for women. As an integral part of the healthcare team, pharmacists can significantly improve awareness and administer the HPV vaccine, yielding enhanced outcomes and cancer prevention.
Referral challenges for early-onset colorectal cancer: a qualitative study in UK primary care
Authors: O'Neill Orla M , Coleman Helen G , Reid Helen
Published: July 2023

Background

The incidence of early-onset colorectal cancer (EOCRC) in adults aged <50 years has increased in several Western nations. National surveys have highlighted significant barriers to accessing timely care for patients with EOCRC, which may be contributing to a late stage of presentation in this population group.

Aim

To explore awareness of the increasing incidence of EOCRC, and to understand the potential barriers or facilitators faced by GPs when referring younger adults to secondary care with features indicative of EOCRC.

Design & setting

Qualitative methodology, via virtual semi-structured interviews with 17 GPs in Northern Ireland.

Method

Reflective thematic analysis was conducted with reference to Braun and Clarke’s framework.

Results

Three main themes were identified among participating GPs: awareness, diagnostic, and referral challenges. Awareness challenges focused on perceptions of EOCRC being solely associated with hereditary cancer syndromes, and colorectal cancer being a condition of older adults. Key diagnostic challenges centred around the commonality of lower gastrointestinal complaints and overlap in EOCRC symptoms with benign conditions. Restrictions in age-based referral guidance and a GP ‘guilt complex’ surrounding over-referral to secondary care summarised the referral challenges. Young females were perceived as being particularly disadvantaged with regard to delays in diagnosis.

Conclusion

This novel research outlines potential reasons for the diagnostic delays seen in patients with EOCRC from a GP perspective, and highlights many of the complicating factors that contribute to the diagnostic process.
PENGARUH SUDUT PAHAT PADA PENGGURDIAN KOMPOSIT SERAT DAUN NANAS / TERMOPLASTIK PADA PEMBENTUKAN DELAMINASI
Authors: Zulkarnain Zulkarnain , Mulyadi Ismet Hari , Jupri Jupri , B Siswandi
Published: July 2023

This study aims to determine the effect of the Gurdi tool angle on delamination in composite laminates in the formation of delaminations. The spacing of the selected reinforcing fibers was 2.4 and 6 mm in a composite laminate of ethylene vinyl acetate (EVA) polymer matrix with reinforcing fibers from pineapple leaves. The method used in composite fabrication is hand lay-up, namely by direct casting on three layers of fiber that has been woven and tied to the sides of the mold. For cutting speed, Vf 72 mm / min, using a chisel with a diameter of 8 mm with a tool angle of 70o and 118o. Delamination was determined using the Feda method. The delamination sections were observed using a digital microscope and then processed using AutoCAD to measure Dmax and Ad. The delamination ratio in the top hole for the tool diameter of 8mm with a 70° angle at the variation of the distance of 2 mm, 4 mm and 6 mm were 1.268, 1.224 and 1.192 for the bottom hole were 1.078, 1.042 and 1.029, respectively. Meanwhile, the ratio of delamination in the upper hole for a tool diameter of 8mm with an angle of 118° at a distance variation of 2mm, 4mm and 6mm were 1.194, 1.194, 1.158 for the bottom hole, respectively, 1.046, 1.042 and 1.038.
Bir Parabolik Oluk Kollektörün Termodinamik Analizi: Yemen Örneği
Authors: ALKUBATİ Eissa , TEMİR Atılgan , ÜÇGÜL İbrahim , BAYRAKÇI Hilmi Cenk
Published: July 2023

Günümüzün en büyük problemlerinin başında enerji kaynaklarındaki hızlı tükenme gelmektedir. Gelişmiş ve gelişmekte olan birçok ülke, diğer ülkelere göre daha fazla enerjiye ihtiyaç duymaktadır. Her geçen gün artan enerji ihtiyaçlarını karşılamak ve enerji maliyetlerini azaltmak maksadıyla yenilenebilir enerji kaynaklarının araştırılması ve verimlerinin artırılması üzerine çalışmalara hız verilmiştir. Yenilenebilir enerji kaynaklarının başında güneş enerjisi gelmektedir. Güneş enerjisinden kullanılabilir enerji üretimi için birçok farklı yöntem mevcuttur. Bu yöntemlerden biri de yoğunlaştırıcılı güneş enerjisi sistemlerdir. Bu sistemlerde ısınarak geçen su ve buhar son üniteden istenilen sıcaklık ve basınç değerlerine ulaşıldığında üretilen buhar doğrudan buhar türbinine gönderilerek karbon emisyonu yaratmadan elektrik enerjisi üretilir. Çalışmada, yoğunlaştırılmış güneş enerjisi sistemlerinden biri olan parabolik oluk kollektörlü enerji üretim sisteminin Yemen’in üç bölgesi için termodinamik analizi yapılmıştır. İnceleme bölgesi olarak iç savaş nedeniyle enerji sıkıntısı çekmekte olan Yemen seçilmiştir. Yemende devam etmekte olan iç savaş, elektrik üretim ve dağıtım altyapılarına zarar vermiştir. Bu da bölgesel ve sık olmak üzere enerji kesintilerine neden olmaktadır. Yemen hükümetinin kontrolü dışındaki bölgelerde yaşayan nüfus bu kesintilerden dolayı ortaya çıkan temiz su temini, temel sağlık hizmetlerine ulaşım ve sanayi üretiminin azalmasına bağlı olarak artan işsizlik gibi sorunlar ile yüzleşmektedir. Savaş nedeni ile çıkarılan petrol ve doğalgaz miktarlarındaki azalma, enerji dağıtım tesislerinin ve altyapısının zarar görmesi enerji arz talep dengesinin sağlanamamasına neden olmaktadır. Bu analiz ile bölgenin ihtiyacı olan elektrik enerjisinin alternatif enerji kaynakları ile karşılanması adına bir ön inceleme yapılmıştır. Alternatif enerji kaynaklarından güneş enerjisinden elektrik üretiminde yoğunlaştırıcılı güneş enerji sistemlerinin ulusal çapta ve bölgesel tesisleşme ile kurulması bu sıkıntıların önüne geçecektir. Bu sayede enerji güvenliği artırılacak, sürdürülebilirlik sağlanarak enerji sıkıntısı çözülecektir. Ayrıca alternatif enerji projeleri, yeni projeler için ön ayak oluşturarak istihdam ortamı yaratacaktır.
Arsenic in Drinking Water Resources in Six Cities Located in the Western Coastal Strip of Libya
Authors: Hassan Tawfik M. , ALamari Nuri Ibrahim , ALmabsout Yousef Alsenusi
Published: July 2023

Water used for drinking and food preparation is the most dangerous source of long-term human exposure to arsenic. The study aimed to identify arsenic level in samples of domestic groundwater, public water supply, bottled water, and water from purification shops in five locations along the coastal strip of Libya. The efficiency of removing arsenic in water by reverse osmosis (RO) unit in two water bottling plants was also investigated. Arsenic was analyzed using inductively coupled plasma optical emission spectrometry (ICP-OES). Results show that arsenic in domestic groundwater, public water supply systems, bottled water, and water from purifying shops range respectively:  6.06-70.48, 2.66-22.76, 1.20-11.20, 2.022-9.55 ug/L. The results revealed that 83% of groundwater samples and 5% of bottled water samples exceeded 10ug/l the maximum permissible level in drinking water by Libyan standards. Meanwhile, water samples from purifying shops are below 10ug/l. Public water supply samples from two sites contained arsenic > 10ug/l. The RO unit is able to reduce arsenic in water by 75%, which means that arsenic in unpurified water should not exceed 35 ug/l. The study highly recommends that households who rely on domestic groundwater should install household RO units to be saved from the health risk of chronic arsenic exposure.
Datos sobre la amoniemia
Authors:   , Formenti Roberto
Published: July 2023

Tabla de contenido: 1 - Introducción: El amoníaco en la sangre circulante: Su origen y destino 2 - La amoniemia en estado normal y patológico 3 - Estudio crítico-teórico de los métodos para su determinación 4 - Datos experimentales obtenidos en el hombre y animales de laboratorio (cobayo) 5 - Acción de los anticoagulantes en la amoniogénesis espontánea "ln vitro" 6 - Conclusiones 7 - Bibliografía
$\Pi$-strategy for a differential game of pursuit with integral constraints of a generalized type
Authors: Samatov B.T. , Horilov M.A. , Juraev B.I.
Published: July 2023

The paper investigates a differential game of simple pursuit, when the controls of two opposing players are subject to integral constraints of a generalized type. The generalization of the proposed restriction lies in the fact that it includes previously known restrictions such as integral, geometric, linear, exponential and their mixtures. In general, it includes 25 types of pursuit problems with such different types of constraints. To solve the pursuit problem under such generalized constraints, we propose a parallel pursuit strategy ($\Pi$-strategy for short) and find sufficient conditions for the solvability of this problem. At the end of the article, tables are provided that list each particular type of game, the conditions for its solvability, the resolving function (which determines the corresponding $\Pi$-strategy), and the time of capture.
Estimation of the solution of asymptotically observable linear completely regular differential-algebraic systems with delay
Authors: Khartovskii V.E.
Published: July 2023

In the article, a problem of solution estimation for linear autonomous completely regular differential-algebraic systems with many commensurate delays is investigated. The class of completely regular differential-algebraic systems with delay under study includes the classes of linear systems of delayed and neutral types; in addition, the analysis of continuous-discrete systems is reduced to completely regular systems.
For linear autonomous completely regular differential-algebraic systems with many commensurate delays, the property of asymptotic observability is determined, which are characterized by the fact that all solutions generating the same output signal are indistinguishable in the future. Conditions for asymptotic observability expressed in terms of the parameters of the original system are formulated and proved. For asymptotically observable systems, a solution estimation procedure is proposed, the implementation of which consists of the following steps. First, using the observed output, a linear autonomous non-homogeneous asymptotically observable retarded type system with a non-homogeneous part depending on the output is put in correspondence with the original system. The solution of the new system uniquely determines the solution of the original system. Then a transformation is constructed that reduces the matrices of the retarded type system to a certain form. After that, with the help of a finite chain of observers, the solution is evaluated. The results of the presented study are applicable to systems that do not have the property of final observability, which makes it possible to significantly reduce the requirements for observing organs when modeling the corresponding objects of the real world.
Connectivity of Urban Spaces Typology and Urban Mobility Topology
Authors: KORKMAZYÜREK Burak , KAHRAMAN Sümeyye , POLAT Erkan
Published: July 2023

In the study, the connectivity of the ontological and epistemological knowledge of the space in intervening in urban transportation and mobility problems is questioned through the sample area. The purpose of the questioning; is to understand whether potential urban mobility analysis and original application principles can be obtained by trying to reflect the epistemological knowledge of the space to the ontological knowledge. Urban mobility studies; it is seen as sustainable and up-to-date approaches that are handled with original preparation, plan, implementation and monitoring processes, that bring together land use regulations, development plans and transportation plans in the solution of urban transportation problems, and combine spatial and other relational dimensions that develop accordingly. As a result of the inquiry, it was determined that the connectivity between epistemological and ontological knowledge of the space effectively solved urban transportation and mobility problems. It has been seen that it is effective in directing planning and design, especially in urban mobility planning, at the lower scale, during plan implementations, or before plan making. The first stage of the study consists of understanding the ontological and epistemological layers of urban space. In the second stage, the connectivities of these layers in intervening in urban transportation and mobility problems are examined. In the study, while producing urban mobility resolutions, improvements were made to the ontological and epistemological layers of the space (topographic, typological, topological, and hodological), and these were tested on the sample area. Thus, it will be understood whether the method to be followed will be valid in other cities.
PELATIHAN PEMBUATAN VIDEO PEMBELAJARAN BAGI MAHASISWA PTI GUNA MEMBENTUK CALON GURU YANG PROFESIONAL
Authors: Baiq Rina Amalia Safitri  , Pahriah  , Wirawan Putrayadi
Published: July 2023

Untuk meningkatkan kemampuan dalam membuat video pembelajaran bagi mahasiswa atau calon guru, guna untuk mendukung keahliannya dalam mengajar, sehingga diharapkan nantinya menjadi guru yang profesional  merupakan tujuan dari pelatihan ini. Pelatihan dilaksanakan di fakultastas sains, teknik dan terapan (FSTT) bagi mahasiswa PTI. Materi yang disampaikan dalam pelatihan yakni bandicam dan canva, capcut. Setelah diberikan materi dengan diajarkan secara step by step kemudian para mahasiswa membuat video sendiri, bias menggunakan aplikasi bandicam dan pengeditan menggunakan canva, capcut. Tahap selanjutnya yakni presentasi video yang sudah dibuat, dan selanjutnya tahap evaluasi dengan memberikan penilaian terhadap hasil karya mahasiswa tersebut. Kesimpulan dari pelatiahan ini, untuk meningkatkan kemampuan dalam membuat video pembelajaran yang dilakukan step by step bertujuan untuk menghindari ketidakpahaman mahasiswa pada setiap langkah pembuatan video, dengan begitu  mahasiswa akan lebih mudah mengerti dan mengaplikasikannya, sehingga mahasiswa berhasil menghasilkan hasil karya video pembelajaran yang menarik dan mudah dimengerti.
PELATIHAN PUBLIC SPEAKING PADA SISWA - SISWI SMKN 1 KAYANGAN KABUPATEN LOMBOK UTARA
Authors: Putra Sandi Justitia , I Made Putra Suryantara  , L. Ahmad Rahmat  , Irma El-Mira Husbuyanti  , Zulhadi  , Ismi Arifiana Rahmandari  , Denda Devi Sarah Mandini
Published: July 2023

Public speaking skills training for students at SMKN 1 Kahyangan, North Lombok Regency. Community Service (PkM) is an effort by a service team to contribute science and technology to society and especially in this case with students. Based on this, the team submitted a proposal for PkM activities in state schools located in North Lombok Regency. The aim of this PkM is to provide basic skill training related to public speaking. This training is expected to provide provisions for students about the benefits of practicing public speaking and is also beneficial for the development of knowledge possessed by students and solving problems related to errors in speaking. The output target of this activity is that the trainees are equipped with public speaking and video recordings of students speaking in front of the camera.
Edukasi dan Penilaian Kesehatan Perumahan di Wilayah Pesisir Kecamatan Ampenan Kota Mataram
Authors: Iwan Desimal  , Ismail Marzuki  , Arif Sofyandi
Published: July 2023

A healthy settlement is a place to live permanently, functioning as a place to live, rest, recreation and as a place of refuge from environmental influences that meet physiological and psychological requirements, free from illness and accident. Ampenan District is located in the western region of Lombok Island and is one of the famous coastal areas for tourist destinations. One of them is Ampenan Beach. It is a common concern that in this area there are rows of houses whose health needs to be considered so that they do not become a source of risk of disease transmission such as tuberculosis, pneumonia and other environment-based diseases related to the home environment. Education is needed to increase the knowledge of residents to avoid environmental-based diseases, especially the residential environment. The method used in community service is to provide understanding and knowledge of liveable healthy homes in the residents of Karang Bunyuk, Ampenan District, Mataram City. Education and assessment of healthy homes is carried out door-to-door (from house to house). Educational media in the form of brochures containing knowledge about calm and healthy homes. Healthy home assessments were carried out on 25 residents' house. Based on the results of a survey we conducted on 25 houses in the Karang Buyuk environment, Ampenan District, it was found that there were 2 houses that met the healthy home standards and 23 houses that did not meet the healthy home standards
Analisis Faktor Penyebab Kesulitan Berbicara pada Mata Pelajaran Bahasa Indonesia
Authors: Azzahra Siti Fatimah , Fahrurrozi Fahrurrozi , Utami Nidya Chandra Muji
Published: July 2023

Ketidakmampuan belajar adalah masalah yang mengakibatkan siswa tidak dapat mengikuti proses pembelajaran dengan baik dan mencapai tujuan pembelajaran yang diharapkan. Tujuan penelitian ini adalah untuk mendeskripsikan bagaimana kemampuan berbicara saat bercerita dalam pembelajaran bahasa Indonesia siswa kelas V SDN Sumberjaya 06. Keterampilan berbicara merupakan bagian penting dari keterampilan berbahasa bagi siswa yang dapat berbicara. lebih mudah untuk mengungkapkan pendapat dan mengungkapkan pikiran. Salah satu cara untuk meningkatkan keterampilan berbicara di kelas adalah dengan bercerita yang berkaitan dengan topik. Penelitian ini merupakan penelitian kualitatif deskriptif dengan menggunakan data dari SDN Sumberjaya 06 SD. Subyek penelitian adalah guru kelas V dan 15 siswa. Pengumpulan data dilakukan melalui tes, wawancara dan dokumentasi. Analisis data dilakukan melalui reduksi data, penyajian data, dan inferensi. Hasil penelitian menunjukkan bahwa keterampilan berbicara siswa dalam bercerita cukup baik. Mengenai keberanian, 7 dari 15 siswa berani bercerita dengan suara lantang dan tatapan mata percaya diri. Dalam hal akurasi, 8 dari 15 siswa memiliki pelafalan dan tata bahasa yang benar. Dalam hal pemahaman, 8 dari 15 siswa menceritakan isi cerita dengan sangat jelas sehingga pendengar dapat dengan mudah memahaminya. Pada bagian fasih, hanya 5 siswa dari 15 siswa yang lancar menyampaikan isi cerita. Mengenai kosa kata, dari 15 siswa, hanya 2 siswa yang bercerita dengan kosa kata yang berbeda sedangkan 13 siswa lainnya masih menggunakan kosa kata yang terbatas. Dari 15 penampilan siswa, hanya 7 siswa yang menggunakan ekspresi. Gestur dan ekspresi wajah menggambarkan gestur dengan melambaikan tangan.
Fare senza parlare equivale a fare a meno di parlare?
Authors: Altissimi Elisa
Published: July 2023

Una nostra lettrice si interroga sull’uso di fare senza + verbo al posto della locuzione fare a meno di + verbo, nello specifico all’interno della frase da lui stesso segnalata “Posso fare senza parlartene?” con valore di “Posso fare a meno di parlartene?”.
CRediT Statement for Recognizing Author Contributions
Authors: Kosycheva Marina A.
Published: July 2023

Authorship is considered to be one of the acute issues of publication ethics. The creation of a system for recognizing the author's contribution promotes the principle of transparency of scientific research. CRediT statement allows objectively recognize the role of each of the authors involved in writing the article and exclude violations of publication ethics in relation to authorship.
Comparative evaluation of enzyme and biocidal activity of Candida auris and Candida albicans
Authors: Ignatova Nadezhda I. , Zaslavskaya Maya I. , Alexandrova Natalya A. , Lapshina Anna A. , Makhrova Tatyana V. , Lukova Olga A.
Published: July 2023

Introduction. Secreted metabolites with enzymatic or toxic properties are important for effecting of Candida spp pathogenicity. The most clinically significant species is C. albicans. However, invasive infections associated with C. auris have a great significance.
The aim of the investigation is comparison the some of enzymatic properties and biocidal activity of C. auris with those of C. albicans.
Materials and methods. C. albicans and C. auris strains were used in the study. Growth of micromycetes was detected on nutrient agar, Sabouraud agar or blood agar (with hemolysis presence). The Candida spp. proteinase activity was determined on Difco agar with 2% casein and by cleavage of IgG molecules. Candida lipase activity was assessed on the agar with Tween-20. The viability of buccal epithelial cells after exposure (1 4 h) with candida metabolites was estimated by trypan blue assay. Statistical analysis was performed using RStudio software.
Results. The best growth of C. albicans was observed on Sabouraud agar, and C. auris on blood agar. Only C. auris had hemolytic and lipase activity. Protease activity of some C. auris strains was noted. They were able to cleave casein and damage IgG molecules. The metabolites of some Candida strains decreased the viability of epithelial cells while the reduction was more pronounced in the experiments with C. auris (р 0.05).
Conclusion. The most suitable medium for C. auris culturing was blood agar. Proteolytic, antiglobulin, hemolytic and lipase activities were observed only for C. auris. C. auris demonstrated more invasive capacity compared to C. albicans. The observed micromycete biocidal activity against buccal epithelial cells was strain-dependent.
Application of immunomagnetic separation for accelerated detection of F. tularensis cells in soil samples using an immunochromatographic test
Authors: Vetchinin Sergey S. , Sheviakov Anton G. , Jakovleva Vera A. , Mironova Raisa I. , Biketov Sergey F.
Published: July 2023

Introduction. Epizootological monitoring of the area contamination with the causative agent of tularemia implies the collection and analysis of a variety of field specimens. The analysis of such objects is time- and labour-consuming. In this context, simple and fast diagnostic techniques are needed to analyze specimens under resource-limited conditions.
Aim. To study the possibility of using immunomagnetic separation for accelerated detection of Francisella tularensis cells in soil samples using immunochromatography.
Materials and methods. Immunomagnetic particles (IMPs) were produced by using monoclonal antibodies to lipopolysaccharide (LPS) of the tularemia causative agent. Soil specimens weighing 1 g with preliminary introduced inactivated F. tularensis 15/10 cells were used in the study. The samples were suspended in an extraction buffer (EB) and filtered. Tularemia cells were separated by IMP suspension. The particles were washed, resuspended in EB and heated at 100C for 5 minutes. The supernatant was analyzed with test strips based on F. tularensis IC-test kit.
Results. A combination of the immunomagnetic separation method and the IC test to detect F. tularensis cells identified up to 1 106 cells of the tularemia pathogen in analyzed soil samples, while 1 107 cells were detected in soil washouts in the absence of immunomagnetic separation.
Conclusion. The developed technique combining immunomagnetic separation and IC tests opens up prospects for express diagnostics of soil sample contamination in tularemia foci. The analysis takes about 3 hours, and its sensitivity is 1 106 cells/g of soil. The technique is simple, not requiring sophisticated expensive equipment. It can be easily adapted for testing other specimen types (water, grain, etc.). In addition, separated bacterial cells can be used for F. tularensis detection by other methods.
Gut microbiota and carcinogenesis: actual aspects
Authors: Poveshchenko Aleksandr F. , Cherkas Valeria N. , Kabakov Aleksey V. , Kazakov Oleg V.
Published: July 2023

The microbiota, together with the host, form a symbiotic relationship in which the microbiota plays a key role in maintaining the homeostasis of the human body, performing a number of significant functions such as energy metabolism, maturation and maintenance of the immune system, vitamin synthesis, regulation of bile acid reabsorption in the intestine, and much more. Scientific research in recent years has made a significant contribution to understanding the complex relationship between the microbiota and a range of human pathologies, including malignant neoplasms.
The review considers the mechanisms of the possible influence of bacteria on the development and progression of cancer with an emphasis on the procarcinogenic properties of the microbiota. The most important factor in the mechanism of influence of the microbiota on carcinogenesis are toxins produced by microorganisms that induce direct damage to host cell DNA, causing DNA mutations, disruption of its exact replication, and also provoke an imbalance in the proliferation and apoptosis of host cells, their rapid aging and oncogenesis. The probable mechanisms of participation of microorganisms in the development of cancer through the activation of TLRs and NLRs receptors, which have a tumor-activating effect, are considered. A brief review is given on the mechanisms of carcinogenesis associated with the metabolic activity of the microbiota due to the processes of regulation of the production of secondary bile acids, activation of pro-carcinogenic compounds: phenols, ethanol, sulfides, ammonia, nitrosamines. The influence of the microbiota on the metabolism of sex hormones and the development of hormone-dependent cancers mediated by the mechanisms of enterohepatic circulation and estrogen deconjugation is described.
The study of the carcinogenic mechanisms of action of the microbiota in the host organism opens up prospects for the development of new successful personalized approaches to the diagnosis, treatment, and prevention of cancer. Changing the composition of the microbiota should become a way to fight cancer, along with surgical treatment, chemotherapy, radiation therapy, targeted therapy and immunotherapy.
Production of Bst polymerase for diagnosis of different infections using loop-mediated isothermal amplification
Authors: Pika Maria I. , Mikheeva Olga O. , Solovyova Elena D. , Valdokhina Anna V. , Bulanenko Victoria P. , Cherkashin Evgeny A. , Petrov Vadim V. , Krasovitov Kirill V. , Cherkashina Anna S. , Akimkin Vasily G.
Published: July 2023

Introduction. The large fragment of DNA polymerase I from Geobacillus stearothermophilus GIM1.543 (Bst DNA polymerase) possesses 5'-3' DNA polymerase activity, 5'-3' displacement activity and high processivity. These properties make it possible to use Bst DNA polymerase in loop-mediated isothermal amplification (LAMP), which provides highly specific amplification of the target sequence and is used for rapid detection of agents causing human infectious diseases.
The purpose of the study was to produce a recombinant Bst polymerase enzyme in the bacterial expression system and to assess its properties for LAMP-based diagnostics of infectious diseases.
Materials and methods. Expression constructs carrying the Bst polymerase gene were obtained using genetic engineering techniques. Different Escherichia coli strains were used for protein expression. Metal-chelate and gel filtration chromatography techniques were used for protein purification. Catalytic characteristics of the enzyme were assessed in loop-mediated isothermal amplification reactions using AmpliSens SARS-CoV-2-IT, AmpliSens IAV-IT and AmpliSens IBV-IT diagnostic systems designed for high-quality detection of SARS-CoV-2, influenza A virus (IAV) and influenza B virus (IBV) RNA, respectively.
Results. The offered protocol for production, extraction and purification of recombinant Bst polymerase makes it possible to produce the enzyme in the bacterial expression system using E. coli cells in a soluble form and reaching the yield up to 20% of the total cell mass. In LAMP reactions, the obtained enzyme demonstrates activity comparable with that of the commercial enzyme Bst 2.0 (NEB).
Conclusion. Considering the fast purification and production of the enzyme, the obtained recombinant Bst polymerase can be used in LAMP-based diagnostic kits.