bluuebunny/crossref_metadata_2025 huggingface dataset:
Literature Review: Potency of Honey Use in Burn Management
Authors: Negara Puspa , Tiara Adelia Hanny
Published: July 2024

Salah satu jenis cedera yang paling fatal adalah luka bakar yang mengakibatkan tingginya angka kematian dan kecacatan. Banyak prosedur pembedahan, rawat inap yang lama di rumah sakit, rehabilitasi intensif, dan perawatan medis yang mahal semuanya berhubungan dengan luka bakar. Tujuan penelitian ini adalah untuk mengetahui pengaruh madu terhadap proses penyembuhan luka bakar. Metodologi yang digunakan dalam penelitian ini adalah tinjauan pustaka. Populasi sasaran penelitian ini terdiri dari jurnal-jurnal yang mengkhususkan diri pada bidang kesehatan. Perawatan luka bakar dengan madu dapat memberikan hasil yang positif. Madu memiliki pH rendah dan memiliki sifat antibakteri. Di antara bakteri, Staphylococcus aureus adalah yang paling responsif terhadap madu. Kesimpulan penelitian adalah madu dapat digunakan sebagai terapi luka bakar.
The Role of Cost Reduction and Cost Control on Organizational Performance by Cost Optimization at PT Pou Chen Indonesia Banten
Authors: Tobing Ishak Saut Parulian L. , Yusuf Furtasan Ali , Hardianto Ade Manggala
Published: July 2024

Kinerja organisasi merupakan hasil kerja organisasi yang direfleksikan dalam bentuk penetapan strategi optimalisasi biaya melalui dua strategi antara lain perusahaan perlu memetakan kembali batas atas biaya (cost control), dan penurunan biaya (cost reducting) pada kinerja organisasi. Metode penelitian adalah metode survei yang menggambarkan persepsi karyawan perusahaan PT Pou Chen Indonesia mengenai variabel penelitian. Teknik sampling yang digunakan adalah random sampling. Teknik pengumpulan data dengan menggunakan goggle form melalui Whats App group. Data responden akan dianalisis dengan alat statistic Structural Equation Model dengan pendekatan Partial Least Squre (PLS). Hasil penelitian menunjukkan: (1) ada pengaruh yang signifikan antara pengaruh cost control terhadap optimizing cost; (2) tidak ada pengaruh cost control terhadap organization performance; (3) bahwa tidak ada pengaruh cost reduction terhadap optimizing cost; (4) ada pengaruh cost reduction terhadap organization performance; serta (5) tidak ada pengaruh optimizing cost terhadap organization performance. Simpulan penelitian ini adalah adaptasi biaya produksi dapat mempengaruhi kinerja organisasi melalui optimalisasi biaya sebagai mediasi antar hubungan antar variabel.
Implementation of Psychological Perspectives in Supporting Differentiated Instructional among Performing Arts Education Students
Authors: Anandhita Nur Arif
Published: July 2024

Perspektif psikologi dapat menjadi salah satu pendekatan yang efektif dalam mendukung implementasi differentiated instructional pada peserta didik. Dengan adanya penerapan perspektif psikologi, pembelajaran pada sebuah kelas dapat dilakukan diferensiasi sesuai dengan kebutuhan setiap peserta didik. Maka dari itu, penelitian ini bertujuan untuk mendeskripsikan implementasi perspektif psikologi dalam pembelajaran berdiferensiasi serta menguji tingkat efektivitasnya. Penelitian ini menggunakan metode penelitian gabungan antara kualitatif deskriptif serta metode penelitian komparatif. Rancangan pembelajaran tersebut didasarkan pada tiga perspektif psikologi yaitu perspektif kognitif, perspektif intelegensi ganda, serta perspektif preferensi/gaya belajar dalam mendukung penerapan pembelajaran berdiferensiasi. Implementasi rancangan pembelajaran tersebut dikuatkan dengan efektivitas pembelajaran yang ditunjukkan dengan perbedaan yang signifikan dilihat dari nilai Sig sebesar 0.000 yang lebih kecil dari 0.05. Hal tersebut juga didukung dengan perhitungan mean pada penerapan strategi pembelajaran yang baru sebesar 88.78 lebih besar dari strategi pembelajaran yang lama dengan nilai sebesar 81.09. Dari data tersebut dapat disimpulkan bahwa terdapat pengaruh yang signifikan dengan adanya implementasi perspektif psikologi dalam pembelajaran berdiferensiasi terhadap peningkatan hasil belajar.
The Role of Work Environment, Work Safety, Job Satisfaction, and Employee Loyalty on Employee Work Performance by A Sense of Happiness and Reward Management HRD Division PT Pou Chen Indonesia
Authors: Putra Imam Maulana , Yusuf Furtasan Ali , Hardianto Ade Manggala
Published: July 2024

Tujuan penelitian adalah untuk mengembangkan model prestasi kerja dengan melibatkan variable rasa bahagia dan penghargaan sebagai variabel mediasi. Peneliti menggunakan metode survey pada divisi HRD PT Pou Chen Indonesia, dan menetapkan sampling random sebanyak 195 sebagai responden penelitian. Teknik pengumpulan data melalui google form yang disebar pada grup karyawan, dan untuk memudahkan peneliti memperoleh data. Hasil penelitian menunjukkan: (1) tidak ada  pengaruh yang signifikan antara lingkungan kerja terhadap rasa bahagia; (2) tidak ada pengaruh lingkungan kerja terhadap penghargaan; (3) tidak ada  pengaruh keselamatan kerja terhadap rasa bahagia; (4) tidak ada pengaruh keselamatan kerja terhadap penghargaan; (5) tidak ada pengaruh kepuasan kerja terhadap rasa bahagia; (6) ada pengaruh kepuasan kerja terhadap penghargaan; (7) tidak ada pengaruh kepuasan kerja terhadap prestasi kerja; (8) tidak ada pengaruh loyalitas terhadap rasa bahagia; (9) ada pengaruh loyalitas terhadap penghargaan; (10) tidak  ada pengaruh loyalitas terhadap prestasi kerja karyawan; serta (11) tidak  ada pengaruh penghargaan terhadap prestasi kerja. Simpulan penelitian ini yaitu untuk meningkatkan prestasi kerja, perusahaan perlu memerhatikan faktor intrinsik (kepuasan kerja) dan ekstrinsik (loyalitas) pada penghargaan, dan mengembangkan model prestasi melaui mediasi rasa bahagia dan penghargaan.
Pemaknaan Kontradiksi “Di Galeng Ngalih Galang” Karya IBM Dharma Palguna
Authors: Pradnya Paramitha Ni Made Ayu Susanthi
Published: July 2024

Esai  “Di Galeng Ngalih Galang” karya IBM. Dharma Palguna merupakan salah satu bentuk tulisan yang digunakan sebagai media komunikasi massa. Gaya tulisannya yang memilih diksi-diksi kontradiktif menjadi daya tarik tersendiri. Tulisan ini bertujuan untuk memberikan pemaknaan kesadaran diri “ke dalam”. Penelitian ini merupakan penelitian kualitatif. Pengolahan data maupun penyajian hasil dilakukan dengan menggunakan metode deskriptif. Sumber data dari penelitian ini didapat dengan menggunakan metode kepustakaan dengan teknik pembacaan teliti dan berulang. Pendekatan yang digunakan yakni semiotik dan dianalisis dengan teknik interpretative. Kontradiksi yang sarat akan makna ini memberikan sebuah gambaran bahwa setiap pertentangan merupakan dua hal yang berbeda namun saling bertaut dan selalu berdampingan seperti sehelai kertas. Tulisan ini juga memberikan pemakmaan bagi setiap individu akan sebuah kesadaran tentang ruang dan waktu, ketenangan jiwa, posisi individu dalam menghadapi masalah, usaha untuk memilih jalan yang tepat, tentang rasa empati, dan menyelesaikan masalah tidak sekadar dari sudut pandang pribadi melainkan juga melihat dari sisi orang lain, yang semua ini bermuara pada kesadaran manusia akan tujuan sejati yang sebenarnya dicari yaitu Tuhan yang dapat ditemukan pada diri setiap makhluk hidup yang ada di dunia ini.
Tantangan Guru Biologi Sekolah Menengah Atas pada Topik Kardiovaskular: Studi di Sidoarjo
Authors: Adrianto Hebert , Firmanto Ian Ardhiya , Bravimasta Bracovanca Diwayestara
Published: July 2024

Kemampuan siswa menganalisis keterkaitan struktur organ, fungsi organ, kelainan atau gangguan yang muncul pada sistem organ menjadi bekal mahasiswa kedokteran tahun pertama di kuliah dan kelas Problem Based Learning (PBL) namun juga menjadi tantangan untuk guru.Penelitian ini bertujuan untuk menganalisis tantangan yang dihadapi oleh guru biologi di Sidoarjo dalam pelaksanaan pembelajaran biologi topik kardiovaskular. Penelitian ini merupakan penelitian observasional cross sectional. Responden adalah guru biologi SMA/MA di Sidoarjo. Metode pengumpulan data menggunakan kuesioner tertutup dan terbuka. Prosedur analisis data adalah pengumpulan data, kuantifikasi data, penyajian data, dan penarikan kesimpulan. Hasil didapatkan persentase guru menilai topik kardiovaskular mudah (4%), sedang (68%), dan sulit (28%). Dominan guru berlatar belakang jurusan S-1 Biologi (70%). Sebagian besar guru pernah kesulitan ketika menyampaikan materi kardiovaskular (90%) dan menjawab pertanyaan siswa (88%) dengan dominan bentuk pertanyaan tentang penyakit (24%). Guru paling banyak menggunakan ceramah sebagai metode pembelajaran (44%). Sebagian besar guru memilih tes golongan darah sebagai praktikum kardiovaskular (30%). Data ini menjadi referensi dasar untuk penelitian pendidikan kedokteran kaitannya dengan kualitas prior knowledge dari input mahasiswa baru jurusan kedokteran, selain itu sebagai dasar program pengabdian masyarakat kepada guru.
STUDY OF NON-FUEL APPLICATION OF BROWN COAL DERIVATIVES IN THE PRODUCTION OF MEMBRANES BASED ON HYBRID BIODEGRADABLE MATERIALS
Authors: Lebedev V. V. , Miroshnichenko D. V. , Bogoyavlenska O. V. , Litvinenko E. I. , Solovey L. V.
Published: July 2024

The article shows research into the non-fuel use of brown coal derivatives in the production of membranes based on hybrid biodegradable materials. The work used polylactide brand Terramac TP-4000, humic substances obtained from brown coals. Membranes for water purification from heavy metals were obtained from hybrid biopolymer materials based on pol- ylactide and humic substances in the form of polymer porous films with a pore size of 20 microns and a working surface area of the membrane of 28.26∙10-4 m2 with a circle diameter of 6 cm. Used in our The work of humic substances belonged to the group of well-hummified, more aromatic with a high content of acidic functional groups, which leads to their high com- plexing ability to form stable metal-humic complexes. The developed hybrid biodegradable materials based on polylactide and humic substances were used as highly effective sorption membrane materials to reduce the content of heavy metals in aqueous solutions. Obtaining membranes of hybrid biodegradable materials based on polylactide and humic substances have maximum selectivity for the extraction of metal ions in relation to Cu2+ – 95 % and Pb2+ – 94 %; and for metals such as Cd2+, Hg2+, Zn2+ and Co2+, it ranges from 82 to 89 %. Comparing the percentage of metal ions adsorbed, it can be seen that the easiest adsorbed metal was lead, copper and zinc adsorbed similarly, with cadmium showing the lowest percentage, but its adsorption was slightly worse than in the case of copper and zinc. The highest value was obtained for single adsorption of Cu2+ ions; in the case of adsorption from a mixture, this metal also had the highest distribution coefficient, and strong adsorption was also found for Pb2+. On the other hand, the adsorption of Zn2+ was, according to the “partition coefficient,” relatively weak. Strong and residual phases were highest for copper and lead, these two metals were largely bound into strong complexes by humic substances and only a very small amount could be washed out under normal conditions. It was found that the leaching of metal ions from mem- brane hybrid biodegradable materials based on polylactide and humic substances into water was very low, in most cases it was about 10 % and did not exceed 20 %. Most of the metal ions (≥60 %) were very tightly bound and were partially leached out under strongly acidic conditions. The obtained results of adsorption resistance vary significantly and correlate well with the age and degree of humification of humic substances.
Structural Health Monitoring of the Roman bridge S. Angelo on the Savuto river (Scigliano, Italy), by integration of a new sensor and geomatic techniques
Authors: Artese Serena , Perrelli Michele
Published: July 2024

The Roman Bridge of S. Angelo, located along the road that connected Capua to Reggio Calabria (Via ab Regio ad Capuam), constitutes an important remain of Roman engineering works and is the best-preserved bridge along the road itself. Located in the middle valley of the Savuto river, this bridge is currently subject to structural monitoring by using various integrated techniques. The monitoring is carried out as part of a series of initiatives aimed at gaining in-depth knowledge and safeguarding a series of historic buildings in the same area. A new type of sensor, characterized by features not offered at the same time by those currently on the market, has been developed to aid structural and environmental monitoring. Previous surveys had been carried out with geomatic techniques; one of the products of these surveys is a 3D model of the bridge, used as input to carry out a Finite Element Modeling (FEM) analysis. The results of this FEM analysis will be compared with those obtained by the measurements carried out with the new sensor. The monitoring campaign, which has just begun, and the expected results are described and commented on. The main results obtained to date are the model of the bridge, a structural analysis and the settlements that have occurred over time as well as the creation of the new sensor.
Deep learning methodologies based on metaheuristics for predictive engine maintenance
Authors: D Pradeep Kumar , J Sowmya B , Kanavalli Anita , S Supreeth , G Shruthi , S Rohith
Published: July 2024

Recently, there has been an increase in concerns about the accessibility, security, and reliability of aviation engines. To prevent engine failures which can be quite serious, it is important to take effective measures. The objective is to create a deep learning simulation that can accurately predict an aircraft engine's viability and remaining usefulness using meta-heuristic techniques to improve its performance. These techniques discover the optimal hyper parameters and architecture for the deep learning model. This will help minimize downtime and maintenance costs for the aircraft fleet by handling complex data such as sensor readings and past maintenance records while also adapting to changing conditions over time. Since training deep learning models can be computationally intensive, meta-heuristic methods increase their robustness. The aim is to enhance performance by increasing the accuracy rate and reducing mean squared losses of multiple deep learning methods used for predicting aircraft engine maintenance by hybridizing them with metaheuristic algorithms.
Possible application of non-invasive tools to characterise European sea bass (Dicentrarchus labrax) and gilthead sea bream (Sparus aurata) from two different farming systems
Authors: Secci Giulia , Pulcini Domitilla , Pulido Rodriguez Lina , Lira de Medeiros Adja , Bruni Leonardo , Parisi Giuliana
Published: July 2024

Rearing conditions can affect fish morphology, physiology, and welfare in several manners, for instance given the different hydrodynamic conditions or stocking densities. This preliminary study aimed to evaluate non-invasive tools to understand if and how the farming system can influence external shape, skin pigmentation, and freshness evolution during refrigerated storage of European sea bass and gilthead sea bream. A total of 100 individuals (50 sea bass and 50 sea bream) were obtained from a fish farm (located in Piombino, Italy) equipped with floating cages and inland tanks. Fishes were photographed in lateral aspect to analyse shape, while skin colour was analysed with a colorimeter. Freshness and Rigor Index were observed during 7 days of refrigerated storage. Results showed that shape and colour analyses can be useful tools to discriminate fish farmed under different conditions, i.e., marine sea cages and inland tanks. Moreover, farming conditions significantly affected rigor resolution and fish freshness, especially in European sea bass.
Reviving Aquileia's late antique walls: A comprehensive Extended Matrix workflow case study
Authors: Delbarba Nicola
Published: July 2024

This contribution aims to provide an overview of a virtual reconstruction case study, focusing on the late antique walls of Aquileia M2, applying the Extended Matrix methodology and its associated workflow. Specifically, we will consider virtual reconstructions in archaeological practice and address their scientific challenges. The report will address the issue of their scientific mapping, briefly touching on existing methods before delving into the details of the Extended Matrix, the chosen methodology for the project. The theoretical foundations and open-source computer tools enabling its comprehensive application will be described. Finally, the focus will be on an illustrative case study of the complete workflow: reconstructing a portion of Aquileia's defensive wall, M2. Following essential historical-archaeological contextualization, the research results leading to the reconstruction hypothesis will be presented, along with some steps to achieve the final model, its visualization through a web app, and potential future development scenarios.
The use of virtualization for the recreation of historical events: The case of the 1562 Auto de Fe of Maní (Yucatan)
Authors: Rodríguez Alcalá Antonio , Chuchiak IV John F. , Raimúndez Ares Zoraida , Rega Maria Felicia , Díaz de León Luis , Erickson Hans B.
Published: July 2024

Virtual modelling is a growing discipline which has become an important tool in the context of heritage preservation. From this point of view, its usefulness is not limited only to the reconstruction of artifacts and built structures, but it also can be an essential tool for the reconstruction of historical events. Utilizing virtual modeling it is possible to create an interactive educational experience aimed at a large audience. Praeteritas Urbes, in collaboration with the National Institute for Anthropology and History’s (INAH) Museo Regional de Palacio Cantón in Mérida, Yucatán led a multidisciplinary group of researchers in the reconstruction of an important historical event for the history of the colonial period in the Maya area: the Auto de Fe of Maní held on July 12, 1562. This article discusses the methodology and the workflow used to complete the project, starting from the architectural reconstruction of the former convent of St. Michael the Archangel in the Maya town of Mani, as well as the virtual recreation of the historical characters, the built space, and the recreation of the scenario of this historical event. An important part of this project involved the digitalization of the museum’s collection of archaeological pieces used for the special exhibition on the Auto de Fe of Maní entitled, Ídolos: Resistencias y Persistencias.
Protecting archaeological collections in Capua Archaeological Museum (Italy): The importance of microclimatic monitoring and non-invasive diagnostic investigations
Authors: Spagnuolo Antonio , Vetromile Carmela , Masiello Antonio , Alberghina Maria Francesca , Schiavone Salvatore , Mantile Noemi , Di Cicco Maria Rosa , Solino Giovanni , Lubritto Carmine
Published: July 2024

This study examines the importance of microclimatic monitoring and non-invasive diagnostic techniques in cultural heritage sites for the identification of critical environmental conditions and the development of appropriate conservation measures. In particular, the research focuses on the microclimate analysis in the 'Sala delle Madri' of the Archaeological Museum of Capua, Italy, which houses a collection of important Roman and Greek sculptures. The study reveals that the microclimatic conditions in the ‘Sala delle Madri’ are not constant throughout the monitored year and the environmental parameter are influenced by seasonal variations and natural phenomena. A preliminary diagnostic investigation has been performed on the sculptures located in this room to document the state of conservation of the sculptures and to plan a specific analytical protocol aimed to characterization of both original and restoration materials, verifying the influence of the microclimatic conditions, due to high temperatures and NO2 levels. Moreover, X-ray fluorescence analysis (XRF) was performed on two archaeological coins to characterize the alloy composition and to document corrosion products and to understand degradation phenomena. This research highlights the necessity for the implementation of conservation measures to mitigate the negative impact of environmental conditions and prevent further damage to the archaeological findings displayed at Capua Museum. This study therefore contributes to the wider awareness of the importance of preserving cultural heritage and the role of monitoring systems in achieving this goal.
Estimation of catapult size and bolt dimensions by comparison of design formulae for early torsion-based catapults
Authors: Paasch Kasper Mayntz , Paasch Alexander Petersen
Published: July 2024

A novel method for the analysis of ancient catapults by comparing two known ancient design formulae for early torsion-based catapults is presented. The hypothesis is that both formulae, one for a bolt shooting catapult and one for a stone thrower, give the optimum design regarding performance and that both express the same optimal design. It is hypothesized that a developed mathematical equation of 3rd order can be used to determine the length and diameter of catapult bolts from bolt point data, for optimally designed catapults, as no such catapult bolt parts so far are known to have been discovered. The method leads to an estimation of the catapult size/dimensions via scaling factors known from ancient sources. Published data from catapult points, known from excavations/literature, were used as the base of the analysis and the development of the mathematical model.
Ancient architectural design interpretation: a framework based on Alexandrian manuals
Authors: Bertacchi Silvia , Juan Vidal Francisco , Fantini Filippo
Published: July 2024

The study of ancient architecture is a wide field that allows the contribution of various disciplines. One of the key issues is the archaeological aspect, which mainly consists of reconstructing the history of the events affecting a particular building and its changes over time. The discipline focusing on design analysis, which starts from the measurement of a building, has a twofold purpose: the definition of the patron’s requirements and objectives, and the solution provided by the ancient professional through the application of specific operational protocols, typical of his time. In this paper we intend to analyse a series of sequential steps based on both graphs and calculations from the technical manuals of the Alexandrian area (1st century AD). Although neglected for a long time and lacking recent critical editions, they can be effectively integrated into the operational flow of various scholars studying ancient architecture from the perspective of measurement. Through some case studies from the Roman imperial period, documented with state-of-the-art devices, authors intend to illustrate the results of this approach integrating new measurement technologies, reverse modelling methods and verification of the results in the light of the texts of Heron of Alexandria focusing on construction.
Setting up a natural resin collection to identify an archaeological black pitch sample
Authors: Valls Mompo Marc , Gallello Gianni , Sáez Giménez Irene , Pastor Garcia Agustín , Esteve Turrillas Francesc Albert , García Puchol Oreto , Mata Parreño Consuelo
Published: July 2024

Natural resins are among the multiple organic materials that have been employed since the prehistory as an adhesive or varnish in the manufacturing processes and operative chains of several tool. For this study, a black pitch sample found inside an amphora was compared with several types of natural resins previously analysed by gas chromatography-mass spectrometry (GC-MS). Different preservation states resins were collected or acquired to be analysed by GC-MS. The results obtained show the reliability and strength of the developed method, while also giving a hint about the raw material employed to coat the amphora.
Documentation and management of complex 3D morphologies through digital technology
Authors: Centarti Lorena , Ferreyra Carla , Guida Caterina Gabriella , Limongiello Marco , Messina Barbara
Published: July 2024

Digital technologies offer an effective solution for documenting and managing complex three-dimensional morphologies, particularly in the context of Underground Built Heritage (UBH). Our research explores novel digitization strategies by employing various technological tools for 3D scanning. We focus on a selected case study: the Grotta di San Michele Arcangelo. Range-based techniques using LiDAR-UAV (Light Detection and Ranging set in Unmanned Aerial Vehicles) were used for the cave’s exterior, integrated with SLAM (Simultaneous Localization and Mapping) technology was employed for the cave’s interior and close-range photogrammetry techniques captured intricate wall decorations. The results yielded precise geometric information crucial for subsequent three-dimensional modelling of architectural and natural spaces. Furthermore, these techniques were integrated to enhance information management, facilitate conservation efforts, and update existing documentation. The resulting comprehensive database is an essential tool for understanding, monitoring, and effectively managing these intricate underground environments.
Technology Focus: Wellbore Tubulars (July 2024)
Authors: Salawu Babatunde A.
Published: July 2024

The oil and gas industry has witnessed significant advancements in downhole technology, driving improved efficiency, sustainability, and well integrity. The technical papers here offer valuable insights into these developments, exploring nonmetallic downhole tubulars, collaborative ecosystems, material selection, environmental sustainability, and mechanical evaluation, showing a promising alternative to traditional steel counterparts.

Paper SPE 214647 explores operational experiences with glass-reinforced-epoxy-lined tubing, highlighting significant benefits such as corrosion protection, cost savings, and improved well integrity. The journey from pilot to large-scale implementation reveals valuable insights into the technology’s evolution and challenges faced by operators.

Complementing this, paper IPTC 23491 emphasizes the pivotal role of ecosystem partners in realizing nonmetallic tubulars. It underscores the need for multidisciplinary collaboration across academia, research institutes, manufacturers, and service providers to navigate challenges and drive innovation effectively.

Paper IPTC 23549, included in the recommended reading list, delves into materials and construction aspects critical for successful deployment. It discusses the selection of nonmetallic materials, pipe-construction considerations, and the importance of standardization to meet stringent downhole requirements, signaling a path toward product development and commercialization.

Concurrently, paper SPE 214488 addresses mechanical evaluations and interventions in nonmetallic tubulars, showcasing advancements in testing methodologies and tool deployment. Insights gleaned from these evaluations inform future research and development efforts to enhance product reliability and performance.

Finally, the carbon life-cycle assessment of nonmetallic tubulars in recommended-reading paper IPTC 24122 underscores environmental sustainability as a driving force behind innovation. By evaluating carbon footprints and life-cycle effects, the industry seeks to adopt ecofriendly solutions without compromising operational efficiency.

The synthesis of these papers underscores the transformative potential of nonmetallic downhole tubulars in reshaping oilfield operations. Through collaborative partnerships, material advancements, rigorous testing, and environmental considerations, the industry strives toward safer, more-sustainable, and more-cost-effective solutions.

Recommended additional reading at OnePetro: www.onepetro.org.

IPTC 23549 Making Nonmetallic Downhole Tubulars a Reality—Materials and Construction by Serena L.M. Goh, Baker Hughes, et al.

IPTC 24122 Carbon Life-Cycle Assessment of Nonmetallic Downhole Tubulars by P. Sarmah, Baker Hughes, et al.
WITHDRAWN: Lab-on-paper platform for disposable molecular testing with USB-powered isothermal amplification and fluidic control
Authors: Kim Hyun Pyo , Park Ji-Ho , Seok Youngung , Kim Min-Gon
Published: July 2024

The full text of this preprint has been withdrawn by the authors as it was submitted and made public without the full consent of all the authors. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Compared effects of repetitive transcranial magnetic stimulation over motor cortex and cerebellum on motor learning during serial reaction time task
Authors: Khanmohammadi Saeid , Ehsani Fatemeh , Bagheri Rasool , Jaberzadeh Shapour
Published: July 2024

Repeated transcranial magnetic stimulation (rTMS) is commonly used to enhance motor learning in older adults. Prior researches have demonstrated different effects of rTMS over the primary motor cortex (M1) and cerebellum on motor learning in older adults. This study aimed to compare the M1 and cerebellar rTMS effects on motor learning in older adults. Seventy healthy older participants were randomly divided into M1, cerebellar, and sham rTMS groups. All participants completed the Serial Reaction Time Task (SRTT) and received 10 minutes of rTMS. In the sham group, the rTMS was turned off after 1 second, while the coils remained. Reaction time (RT) and error rate (ER) were recorded before, immediately, and 48 hours after the rTMS intervention during pre and post-tests of SRTT. RT and ER decreased during SRTT in all groups (P < 0.001). Intervention groups showed greater online learning compared to the sham group (P < 0.05). Additionally, intervention groups exhibited offline learning and consolidation effects with more significant changes in cerebellar-rTMS group (P < 0.03), while the sham rTMS group could not maintain it (P > 0.05). Findings indicated the effects of both M1 and cerebellar rTMS with a more consolidation efficacy of cerebellar rTMS on motor learning in older adults.
The p.Gly2019Ser is the commonest pathogenic mutation in the LRRK2 gene among Egyptians with familial and sporadic Parkinson's disease
Authors: Salama Mohamed , William Martina , Hamed Sharifa , Shalash Ali , Khedr Eman , Yousef Mohamed , El-Jaafary Shaimaa , Fawi Gharib , Helmy Asmaa , Hamid Eman , Essam Mohamed , Lee Hamin , Jama Alina , Korayem Mohamed , Mahmoud Doaa , Elfarrash Sara , Elsaid Yasmin , Gabr Asmaa , Shebl Nourhan , Abdelwahhab Nesreen , Belal Tamer , Elsayed Nehal , El-Gamal Mohamed , Elgamal Shimaa , Ragab Salma , Mekky Jaidaa , Mohamed Lobna , Shamma Samir , Ragab Gaafar , Hussein Mohamed , Hegazy Mohamed , Houlden Henry , Rizig Mie
Published: July 2024

The impact of LRRK2 variants on the risk of Parkinson's disease (PD) in Egyptians remains unknown. We examined 1,210 Egyptians (611 PD patients and 599 controls) for 12 LRRK2 mutations. The p.Gly2019Ser was the only variant detected across Egypt, with a prevalence of 4.1% in sporadic cases, 6.5% in familial cases, and 0.68% in controls. Among p.Gly2019Ser carriers, all were heterozygous bar one homozygous patient, and all shared the common haplotype 1. Demographics and UPDRS scores did not differ between carriers and non-carriers, with most patients being males and developed PD in their fifties. Early-onset PD prevalence was 33% in carriers and 25% in non-carriers. Familial cases were 16% in carriers and 11% in non-carriers. This study affirms that like other North Africans and Mediterranean populations, Egyptians with PD have a notably high prevalence of the p.Gly2019Ser. LRRK2 inhibitors could be promising therapeutic options for further exploration in this population.
The Genetic Causal Association between Socio-economic Status, multiple psycho-emotional Disorders, obesity and Risk for Rotator Cuff Syndrome: A Two-sample Mendelian Randomization
Authors: jiang Yankun , Shen Yanzhu , Sun Guoyuan , Wang Weiguo , Zhang Qidong
Published: July 2024

Objective: Previous studies have linked socio-economic status (SES), multiple psycho-emotional disorders, and obesity to an elevated risk of rotator cuff syndrome(RCS); however, the causal relationship remains unclear. Here, Mendelian randomization (MR) to investigate the causal relationship.
Methods: We examined the correlation between SES, multiple psycho-emotional disorders, obesity, and RCS. Instrumental variables for RCS were selected from the FinnGen biobank by the MRC Integrative Epidemiology Unit at the University of Bristol (IEU) Genome-wide association studies(GWAS) database project. socio-economic status, multiple psycho-emotional disorders, and obesity genetic data came from a UK-biobank GWAS computational model study. Inverse variance weighted (IVW) MR was the primary method used. Sensitivity analysis, MR-pleiotropy residual sum, and outlier (MR-PRESSO) were used for further comparisons.
Results: Based on the IVW method, we found that genetically determined age completed full-time education[IVW odds ratio(OR) =0.466,95% confidence interval (CI)=0.276,0.786, P=0.004] was identified protective effects on RCS risk, and unfavourable effects of higher genetically predicted Job involves heavy manual or physical work(IVW OR=2.042, 95%CI=1.007,4.142 ,P=0.048 ),Tense / 'highly strung'(IVW OR=6.635, 95%CI=1.148,38.356,P=0.035 ),Body mass index (BMI)(IVW OR=1.276 , 95%CI=1.099 ,38.356,P=1.481),Waist circumference(IVW OR=1.450, 95%CI=1.247 ,1.687 ,P＜0.001 ). The rest of the results were negative.
Conclusions: This two-sample MR study provides evidence of a causal association between low level of education, heavy manual work, highly tense psychological characteristics, obesity, and increased RCS in a European population. Therefore, early screening and education in the above-mentioned population are of great significance for RCS risk management.
Investigating the effect of melatonin on serum changes of Adropin in patients with diabetic retinopathy, A randomized clinical trial
Authors: Javadzadeh Alireza , ghodraty peyman , saeedi-maleki zahra , Ghorbanihaghjo Amir , Brumandpur friborz , mousavi faride
Published: July 2024

Background: This study aimed to determine the effect of oral melatonin on adropin serum levels in patients with diabetic retinopathy(DR)
Methods and Design: This randomized, single-blind clinical trial involved 22 patients with DR who received additional treatment of 3 mg/day melatonin for three months (group A) and 22 age-matched patients with DR who got only the routine treatments (group B) A complete ophthalmic examination, including best corrected visual acuity (BCVA) (based on LogMAR) and slit lamp examination, was done. DR grading was based on Early Treatment Diabetic Retinopathy Study (ETDRS) guidelines. serum levels of adropin, MDA, and hs-CRP were measured and repeated after 3 months. Descriptive statistics were used to describe demographic characteristics and inferential statistics (Mann Whitney U test, Spearman's rank correlation test) were used to describe the characteristics of the population, and the statistical significance level was set at P < 0.05.
Results: Significant differences between the melatonin and control groups (both before and after the treatment) were seen with MDA (P = 0.005) and Adropin (P = 0.001), but there were no significant differences between the biochemical parameter levels. Also, there were no Significant correlations between the changes in Adropin level with biochemical parameter levels in three months.
Conclusions: In conclusion, our study suggests that using melatonin alongside routine DR treatments may increase serum adropin levels and decrease the oxidative stress and inflammatory process of diabetes for this reason we may consider a therapeutic role for melatonin in treating diabetic retinopathy.
Smoking in patients with schizophrenia: Prevalence rate and connections with cognitive functions, psychiatric symptoms, and clinical and demographic characteristics
Authors: Wu Caili , Dagg Paul , Molgat Carmen , Grishin Nataliya
Published: July 2024

Purpose
Many studies have shown that cigarette smoking prevalence rate is high in patients with schizophrenia. Despite the strong association between smoking and schizophrenia, findings on the relationships between smoking, psychiatric symptoms and cognitive functions remain mixed. Furthermore, the smoking rate among acute inpatients who need tertiary mental health care is still unknown. We investigated the smoking rate in this patient population. We also examined connections between smoking and cognitive functions, psychiatric symptoms, and clinical and demographic characteristics.
Methods
A retrospective chart review of patients admitted to a tertiary acute psychiatric facility over a 7-year period was conducted. Information such as patient smoking status, diagnosis, and psychiatric assessment scores, was retrieved. Independent samples t-tests and Chi-squared tests were used to compare variables between smoker and non-smoker groups.
Results
The smoking prevalence rate was 72%, approximately four times the smoking rate in the general population in Canada. Compared to the non-smoking group, the smoking group were significantly younger, more likely to be male, had less years of education, shorter illness duration, higher rate of concurrent substance use disorder, and less days of hospital stay. However, the two groups did not show differences in severity of illness, types/numbers of medication used, positive and negative symptoms, and cognitive impairment.
Conclusion
Smoking status appeared to be associated with several demographic and clinical features. Smoking did not significantly relate to patients’ illness severity, medication use, psychiatric symptoms, or cognitive functions.
RASSF1A Promoter Methylation Patterns in the Pathogenesis of Preeclampsia
Authors: Liu Qing , Li Xueyan , Zheng Yuanyuan , Ding Xin
Published: July 2024

In this study, we explored the epigenetic basis of preeclampsia, focusing on hypermethylation of the RASSF1A gene promoter - a topic of growing interest in the field of placental pathology and maternal health. While numerous studies have attempted to unravel the mystery of the etiology of preeclampsia, its pathogenesis remains elusive, challenging the development of precise diagnostic tools and therapeutic approaches. Our study, conducted ethically, documents a comprehensive examination of RASSF1A expression, utilizing advanced methods such as real-time PCR, immunohistochemistry, and immunofluorescence staining to quantify methylation and its functional consequences. The study revealed a profound association between RASSF1A promoter hypermethylation and clinical markers of preeclampsia, including hypertension, proteinuria, and reduced neonatal birth weight. Cell models that replicate the hypoxic conditions encountered in preeclampsia reinforced the link between hypoxia and epigenetic changes in RASSF1A, providing insights into the potential reversibility of gene silencing. This study advances the understanding of the role of RASSF1A in preeclampsia and its potential as a biomarker and epigenetic therapeutic target. Our findings encompass the clinical significance of RASSF1A hypermethylation and suggest a promising trajectory for the use of epigenetic modulation in the management of preeclampsia.
Impact of pre-pregnancy and pregnancy sleep on the risk of postpartum depression in the Japan Environment and Children’s Study
Authors: Suetsugu Yoshiko , Michikawa Takehiro , Morokuma Seiichi , Hamada Norio , Kikuchi Kimiyo , Ikeda Subaru , Shimada Yukiyo , Kato Kiyoko , Ochiai Masayuki , Tsuji Mayumi , Shimono Masayuki , Yoshino Kiyoshi , Suga Reiko , Kawamoto Toshihiro , Ohga Shouichi
Published: July 2024

This study aimed to determine the longitudinal effects of pre-pregnancy and pregnancy sleep on maternal depression at one month postpartum, stratified by parity. We used data from the Japan Environment and Children’s Study, a cohort study that registered 103,060 pregnancies between 2011 and 2014. A total of 76,977 women were included in this study and were asked about their sleep pre-pregnancy and during pregnancy, and whether they had postpartum depression. We found that those who slept 8–9 hours in pre-pregnancy had slightly lower odds of postpartum depression compared with those who slept 7–8 hours (odds ratio OR = 0.92, 95% confidence interval CI:0.87–0.99), and those who had bedtimes other than 9 p.m. to 3 a.m. had increased OR compared with those who had bedtimes between 9 p.m. and midnight (OR = 1.14, 95% CI:1.00–1.31). During pregnancy, those who slept less than 6 hours and whose bedtime was other than 9 p.m. to 3 a.m. had increased ORs of postpartum depression (OR = 1.21, 95% CI:1.09–1.31; OR = 1.25, 95% CI:1.08–1.45, respectively). Poor sleep quality during pre-pregnancy and pregnancy increased the odds of postpartum depression. To prevent postpartum depression, it is important for women to have good sleep from pre-pregnancy.
Influence of depression severity on interhemispheric functional integration: An analysis from the REST-meta-MDD Database
Authors: Ding Jie , Peng Junfeng , Zhang Qian
Published: July 2024

Major depression disorder (MDD) is a pervasive mental health disorder that significantly impairs functionality, underscoring the need for precise stratification of its severity to tailor effective treatment. This study investigates the utility of voxel-mirrored homotopic connectivity (VMHC) in resting-state fMRI data as a neuroimaging biomarker to distinguish between different severities of patients with MDD. The results revealed significant reductions in VMHC within the fusiform gyrus in cased of mild to moderate depression, and more extensive reductions across the insula, postcentral gyrus, and angular gyrus in severe depression. Interestingly, increased VMHC in the middle cingulate cortex was observed in the severe MDD patients compared to those with mild to moderate cases, and this increase showed a significant positive correlation with the symptom scores. Additionally, receiver operating characteristic (ROC) curve analysis indicated that VMHC values in these regions effectively differentiate patients from healthy controls and across severities of MDD. These findings suggest that VMHC could serve as a valuable tool for clinical diagnosis and the stratification of depression severity, providing insights into the underlying neurobiological mechanisms of the disorder.
Morphometric examination of the larynx in Turkish population
Authors: Bilgen Sevgi , Dogan Muzeyyen , Eren Bulent , Inanir Nursel Turkmen , Fedakar Recep , Erdogan Dilek
Published: July 2024

Purpose
The aim of this study was to measure laryngeal dimensions in a sample of Turkish cadavers including males and females of various ages and heights.
Materials and Methods
Morphological measurement was performed on 102 laryngeal specimens. Hyoid bone and laryngeal cartilages were removed from human cadavers. All dimensions of the cartilages were measured using a thread and vernier calipers. Age, sex, and height were recorded. All the parameters for male and female were compared. Statistical comparisons were made using Student's t-test and Pearson's correlation.
Results
The following measurements were significantly greater in male than in female: length of the greater horn of hyoid bone (p < 0.05) and hyoid body heights (p < 0.001), length and width of epiglottis (p < 0.001), transvers and anteroposterior diameters and anterior and posterior thicknesses of the cricoid (p < 0.01). The dimensions of male and female thyroid cartilages differed significantly (p < 0.001). Age was not significantly correlated with any parameter tested. Height showed weakly significant positive correlations with hyoid body height, epiglottis height, lateral and anteroposterior diameters of the cricoid, posterior thickness of the cricoid, thyroid superior horn length, lamina breadth and anterior height.
Conclusion
Mean measurements were significantly greater in males than in females. However, there was no significant correlations between age and any parameter examined. Weakly significant positive correlations were observed between height and hyoid bone and laryngeal cartilage measurements. This study is the first cadaver study to investigate epiglottis, cricoid and thyroid cartilage, and hyoid bone measurements in the Turkish adult population with such a large sample size.
FT3/FT4 ratio in a certain range was identified as an independent protective factor for glycemic variability in patients with type 2 diabetes
Authors: Li Ying , Pan Tianrong , Wang Lingyu , Wang Yue , Gong Yu , Wang Guojuan , Zhang Qianqian
Published: July 2024

Context: Thyroid hormone (TH) plays a crucial role in regulating glucose metabolism. However, the potential impact of the FT3/FT4 ratio, which reflects peripheral sensitivity to thyroid hormones, on glycemic variability in patients with type 2 diabetes (T2DM), has not been previously reported.
Objective: To investigate the correlation between the FT3/FT4 ratio and glycemic variability in individuals with T2DM.
Methods: In this retrospective analysis, a total of 468 inpatients with T2DM underwent continuous glucose monitoring (CGM) systems for a period of 6-14 days. Baseline clinical characteristics, laboratory tests, and CGM parameters were documented to investigate the correlation between FT3/FT4 ratio and CGM parameters.
Results: The levels of HBA, MG, SD, CV, LAGE, MODD and TAR2Scale were all higher in FT3/FT4Q1 compared with FT3/FT4Q2, FT3/FT4Q3 and FT3/FT4Q4 (all P<0.01). Additionally, TIR was lower in FT3/FT4Q1 compared with the other quartiles (P<0.01). Smooth curve fitting and saturation effect analysis revealed that there are curve-like relationships between the FT3/FT4 ratio and SD, MAGE, MODD and TAR2Scale. The inflection points of the fitted curves were found to be at FT3/FT4=0.279, 0.237, 0.253 and 0.282 respectively (all P<0.05). Prior to the inflection point, the FT3/FT4 ratio was negatively related to SD, MAGE, MODD and TAR2Scale (all P<0.05). Furthermore, The FT3/FT4 ratio exhibits a negative linear correlation with HBA and MG, while demonstrating a positive linear relationship with TIR (all P<0.05). Binary logistic regression demonstrated that the FT3/FT4 ratio was independently related to HBA (P=0.001), MG (P=0.01), TAR2Scale (P=0.003), LAGE (P=0.014) and MAGE (P< 001).
Conclusion:The FT3/FT4 ratio plays a crucial role in glycemic control, acting as a protective factor for minimizing glycemic fluctuation in patients with T2DM when it increases within a specific range (FT3/FT4 ≤ 0.282). This suggests that heightened sensitivity to thyroid hormones within a certain range contributes to improved glycemic control and reduced glucose fluctuation.
CHOP is insufficient for newly-diagnosed subcutaneous panniculitis-like T-cell lymphoma patients: A retrospective study of 32 patients in China
Authors: Chen Chao , Yin Jingjing , Wang Wei , Zhao Danqing , Wei Chong , Jia Congwei , Zhang Wei , Zhou Daobin , Zhang Yan
Published: July 2024

Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare subtype of cutaneous lymphoma, and the standard of care for SPTCL has not been well-defined. This retrospective study analyzed the efficacy of the CHOP-regimen in newly-diagnosed SPTCL patients in China. The study reviewed 32 SPTCL patients treated at Peking Union Medical College Hospital over the last two decades. The median age of these patients was 27 years. Among them, 56.3% were female. 50% patients had a PIT score ≥ 2, and 28.1% patients had concurrent hemophagocytic lymphohistiocytosis. Histopathology typically showed a lobular panniculitis with individual adipocytes surrounded by atypical lymphocytes, usually with a CD3+, CD4−, CD8+, CD56− phenotype. 28 patients (87.5%) received CHOP-like regimen as the first-line treatment. The ORR and CR rate of induction therapy were only 42.9% and 35.7%, respectively. The median PFS and OS were 3.2 months and 147.5 months. Factors, concurrent HLH and PIT ≥ 2, were indicators of shorter PFS in univariate analysis. As the largest retrospective SPTCL cohort in Asia, the result showed that CHOP-like regimen was inadequate as a first-line treatment for SPTCL, emphasizing the need for alternative therapeutic strategies.