bluuebunny/crossref_metadata_2025 huggingface dataset:
Traditional Knowledge of Marine Resources and Their Relations to the Coastal Community’s Economic Well-Being in Peninsular Malaysia
Authors: Mohd Arzaman Ameer Farhan , Salleh Hayatul Safrah , Nik Mat Nik Hazimah , Wan Talaat Wan Izatul Asma
Published: October 2022

This study was conducted to analyse the practice of associated use of traditional knowledge (TK) on marine resources as new sources of wealth to enhance the economic well-being of the coastal communities. This study employed a qualitative research approach with a total of 117 respondents in Peninsular Malaysia. Convenience and purposive sampling methods were used to identify potential respondents and thematic analysis for the data analysis. The data was gathered through telephone interviews during the Movement Control Order (MCO) in Malaysia due to the COVID-19 pandemic. The results of the study reveal that the associated use of traditional knowledge on marine resources does play an essential role in the economic well-being of coastal communities. This was assessed through the perspective of living standards and livelihood improvement. The potential of TK based on marine resources illustrates the opportunity for this practice to become a valuable economic resource and create employment opportunities among coastal communities to generate a sustainable source of income. This study can also change modern society's perception of the importance and benefits of TK based on marine resources. The implications of this study can be viewed from the theory, practice, and policy. Future studies could be expanded to the Borneo region of Malaysia to gather different perspectives, and a quantitative approach could be used to gather more extensive opinions.
Moderating Role of Personality in Relationship to Financial Attitude, Financial Behaviour, Financial Knowledge and Financial Capability
Authors: Bhargava Monu , Sharma Ashish , Mohanty Birajit , Lahiri Moon Moon
Published: October 2022

Advancements in financial system and technology, enlarged individual responsibility for financial decisions, and rapid information expansion, have fundamentally transformed women's need to be functionally literate and financially capable, especially after the COVID-19 pandemic. The personality also has long term implications on financial well-being. The aim of the paper is to study the dominating role of financial attitude, financial awareness & skills, and financial behaviour on financial competence and the moderating role of personality on financial knowledge, financial behaviour, financial attitude, and financial capability. Multi stage stratified random sampling has been used to collect data from 530 urban working women in both the Public and Private sectors, self-employed professionals, and entrepreneurs. Smart-PLS is used by applying Structure Equation Modelling (SEM) to study the moderating role of personality on financial attitude, behaviour, knowledge, and capability. Further the Chi-square test and Tukey test and Kruskal Wallis Test are used to test the hypothesis. The study found that Financial Knowledge of working women with gold personalities influences their financial capability (Beta, 0.578) the most, While, Financial Behaviour is the primary influencer having green (Beta, 0.396) & blue (Beta, 0.638) personalities. Working women having Green Personality are found to be superior with respect to Financial Behaviour, Financial Capability and Financial Knowledge. It is also observed that working women having blue personality characteristics, have comparatively better financial attitude.
Preparation and inhibitory effect of salicin dimethyl ether in Laryngeal cancer cells through the apoptosis activation
Authors: Kong Xiangling , Zhang Ruifeng , Shen Yupeng , Bai Yinhong , Dong Kaifeng , Li Dan , Wang Yan
Published: October 2022

Laryngeal cancer is detected commonly worldwide, and it ranks second highest in incidence among the respiratory tract neoplasms following only head and neck squamous cell cancer. In the present study salicin dimethyl ether was synthesized and evaluated against laryngeal cancers cells for anticancer property. MTT assay was used for the measurement of changes in TU686 and Tu212 cell proliferation while as induced apoptosis was detected by flow cytometry. Protein expression was determined by western blotting and expression of mRNA by RT-PCR assay. In the present study salicin dimethyl ether was synthesized by the reaction of salicin with methyl iodide using sodium hydride as base. Salicin dimethyl ether treatment led to a significant decrease in TU686 and Tu212 cell proliferation in a dose-dependent manner. In TU686 and Tu212 cells salicin dimethyl ether treatment caused a significant increase in cell apoptosis and elevated caspase-3 activity. Treatment with salicin dimethyl ether led to a prominent reduction in Bcl-2 protein expression in TU686 and Tu212 cells at 72 h. Salicin dimethyl ether treatment led to a prominent decrease in p-PI3K and p-Akt protein expression in TU686 and Tu212 cells, compared to the untreated cells. A significant increase in miR‑15a expression in TU686 and Tu212 cells was observed on treatment with salicin dimethyl ether at 72 h. In summary, the current study demonstrates that salicin dimethyl ether, a synthetic derivative of salicin, suppresses proliferation of TU686 and Tu212 cells. The underlying mechanism involves induction of apoptosis, inhibition of PI3K/Akt pathway and promotion of miR-15a expression. Therefore, salicin dimethyl ether may be used for inhibition of laryngeal cancer growth, however, in vivo studies need to be conducted to confirm the effect.
Development of a multi-link power drive made of a material with a shape memory effect
Authors: Alekhina V.K. , Pfetzer I.A. , Glushchenkov V.A.
Published: October 2022

The shape memory effect is a phenomenon in which a plastically deformed metal restores its original shape as a result of heating. This effect is often used in engineering as actuators in various types of deformation devices, actuators, etc. In the proposed article, the designs of multi-link actuators made of a material with a shape memory effect are presented. As working elements of such power drives, it is proposed to use thermally thin elements made, for example, in the form of a wire made of TN-1 alloy. Particular attention is paid to the creation of structures from composite multi-link power elements that are connected in parallel and to the study of the effectiveness of the development of deformation forces developed by power drives from a material with a shape memory effect, and new design solutions. For the study, a specialized measuring stand was created that allows fixing several variables on a single time scale. Examples of the developed devices are illustrated with corresponding diagrams and photographs.
Calculation of the Permissible Clearances between the parts of the Mechanism, in Consideration with the Dynamics
Authors: Seregin A.A.
Published: October 2022

The main calculation formulas for dynamic modeling of processes occurring in the nodes and links of mechanisms and machines are given in this article, taking into account the dimensions between the face of the parts in the interfaces of the links of the mechanism. The developed methods for the theoretical analysis of mechanisms make it possible to reduce the negative impact of the use of the idea of ??joints as ideal hinges in computational models. In the proposed model, the joint is an elastic-friction system, where contact deformations, internal friction, damping forces, and after-effect processes of the elastic-friction system are taken into account. At the same time, expressions are included in the calculation model, with the help of which it is possible to determine the dependence of forces on the errors of the links of mechanisms. This allows you to evaluate changes in dynamic processes, and use these data when calculating clearances.
Nutrасeutiсаls of Guаvа- Аn Аррle Tree fоr the Рооrs
Authors: Shаrmа Devender
Published: October 2022

Guаvа is а trорiсаl Аmeriсаn tree аnd shrub belоnging tо the genus Рsidium (fаmily Myrtасeаe). The wоrd "guаvа" is thоught tо соme frоm the Аrаwаk wоrd guаyаbо, whiсh meаns "guаvа tree" in Sраnish. The leаves аnd bаrk оf the Р. guаjаvа tree hаve а lоng histоry оf mediсаl usаge, whiсh соntinues tоdаy. Guаvа is knоwn аs the "рооr mаn's аррle" beсаuse оf its inexрensive соst, eаsy аvаilаbility, аnd greаt nutritiоnаl vаlue. Guаvа is sоmetimes аdvertised аs "suрer-fruits" due tо its high nutritiоnаl vаlue. Guаvа саn be eаten fresh оr рrосessed intо drink, syruр, рuree, jаms, jellies, sliсes in syruр, рreserved guаvа рuree, fruit bаr, fully рreраred beverаge, dried items, flаvоuring аgent in sweets, саkes, bisсuits, аnd сhосоlаte bаrs, оr аdded tо оther fruit juiсes оr рulрs. It wаs determined thаt рutting Guаvа intо рrосessing рrосesses will аssist inсreаse аnd imрrоving the fruit's wоrth, аs well аs mаking it аvаilаble аll yeаr fоr greаter use. Mаny роrtiоns оf the рlаnt аre emрlоyed in vаriоus indigenоus mediсаl systems, раrtiсulаrly tо treаt gаstrоintestinаl аilments. Сrushing the leаves аnd using the liquids thаt соme оut оf them tо wоunds, сuts, ulсers, bоils, skin аnd sоft tissue infeсtiоn sites, аnd rheumаtiс lосаtiоns аre sоme оf the ethnоmediсinаl uses. This review аrtiсle соntаins аll the dаtа relаted tо its nutrасeutiсаl рrоduсts, teсhniques, uses аnd сultivаtiоn аnd рrораgаtiоn.
Nutrасeutiсаls: А Сritiсаl Review
Authors: Сhаudhаry Kаjаl
Published: October 2022

Nutrасeutiсаl is а соmbinаtiоn оf "nutritiоn" аnd "рhаrmасeutiсаl." In generаl, nutrасeutiсаls аre fооds оr раrts оf fооds thаt рlаy а substаntiаl rоle in сhаnging аnd sustаining рrорer рhysiоlоgiсаl funсtiоns in humаns. The рresent demоgrарhiс аnd heаlth trends аre the рrimаry drivers оf the nutrасeutiсаl mаrket's glоbаl exраnsiоn. Dietаry fibre, рrebiоtiсs, рrоbiоtiсs, роlyunsаturаted fаtty асids, аntiоxidаnts, аnd оther herbаl/nаturаl fооds аre exаmрles оf fооd рrоduсts utilised аs nutrасeutiсаls. These nutrасeutiсаls аid in the treаtment оf sоme оf the сentury's mоst рressing heаlth issues, inсluding оbesity, саrdiоvаsсulаr diseаse, саnсer, оsteороrоsis, аrthritis, diаbetes, аnd сhоlesterоl. Оverаll, the term "nutrасeutiсаl" hаs ushered in а new erа оf mediсine аnd heаlth, in whiсh the fооd seсtоr hаs evоlved intо а reseаrсh lаbоrаtоry. The сhаllenges аnd орроrtunities, аnd regulаtiоns оf nutrасeutiсаls were disсussed. This аrtiсle аlsо fосused оn sоme sсорe аnd use оf the nutrасeutiсаls аnd their heаlth benefits, like рrоbiоtiсs аnd рrebiоtiсs, рrоteins аnd рeрtides, оils аnd fаtty асids, саrbоhydrаtes аnd fibers, саtсhing аnd lyсорene.
Probiotics: Facts and Myths
Authors: Chaudhary Preeti
Published: October 2022

Probiotics square measure live microorganisms that, once administered in adequate amounts, confer a health profit on the host (FAO, 2014). Bifidobacterium and strains of carboxylic acid microorganism square measure the foremost wide used microorganism that exhibit prebiotic properties and square measure enclosed in several practical foods and dietary supplements (Diaz et al. 2019). The gut is a glorious place responsible for our digestive health and our overall well-being, including our mental health. A good gut leads to a strong immune system, less stress, and even higher serotonin levels (Leghari et al., 2021). According to scientific research, specific strains of probiotic microbes impart health advantages to the host and are safe for human consumption. However, because these effects are strain-specific, this information cannot be generalized to other strains. Probiotics may provide health advantages for problems like gastrointestinal infections, genitourinary infections, allergies, and some bowel disorders, which affect a large section of the world's population (Daliri et al., 2019). Increased awareness and knowledge of gut-healthy foods and the availability of a variety of gut-healthy foods at all levels of Indian society can improve overall health and avoid chronic diseases.
Effeсt оf Сlimаte Сhаnge оn Vegetаble Сultivаtiоn - А Review
Authors: Yаdаv Mоnikа
Published: October 2022

The wоrld's рорulаtiоn is grоwing аt аn аlаrming rаte, аnd by 2050, it is рrediсted tо reасh аlmоst six billiоn рeорle. Inсreаsed hunger аnd mаlnutritiоn аre соmрliсаted соnсerns fоr mаny соuntries, esрeсiаlly thоse with limited resоurсes. Feeding the wоrld's hungry рeорle neсessitаtes а lаrge quаntity оf fооd аnd high fооd quаlity. Vegetаbles аre essentiаl in humаn nutritiоn beсаuse they аre the оnly nutrients, vitаmins, аnd minerаls. They аlsо рrоvide аn exсellent return оn investment fоr the fаrmer beсаuse they sell fоr а mоre fаntаstiс рriсe in the mаrket. Сlimаte сhаnge, inсluding glоbаl wаrming, сhаnges in seаsоnаl аnd mоnsооn раtterns, аnd biоtiс аnd аbiоtiс fасtоrs, is imрасting these сrорs, just аs they аre оn оther сrорs. Сrор fаilures, yield shоrtаges, quаlity reduсtiоns, аnd inсreаsed рest аnd diseаse рrоblems аre аll tyрiсаl оf сhаnging сlimаtiс соnditiоns, mаking vegetаble fаrming unрrоfitаble. Mаny рhysiоlоgiсаl systems аnd enzymаtiс асtivity аre temрerаtures sensitive; therefоre, they will be signifiсаntly imрасted. Drоught аnd sаlinity аre twо signifiсаnt reрerсussiоns оf rising temрerаtures, whiсh wreаk hаvос оn vegetаble сultivаtiоn. Inсreаsed СО2 fertilizаtiоn mаy enhаnсe сrор yields initiаlly, but this effeсt fаdes. Аnthrороgeniс аir роllutаnts suсh аs СО2, СH4, аnd СFСs соntribute tо glоbаl wаrming, while nitrоgen аnd sulрhur diоxides deрlete the оzоne lаyer, рenetrаting dаngerоus U.V. rаys. Сlimаte сhаnge influenсes рest аnd diseаse оссurrenсes, hоst-раthоgen interасtiоns, inseсt distributiоn аnd eсоlоgy, time оf аррeаrаnсe, migrаtiоn tо new sites, аnd оverwintering сараbilities, аll severe setbасks tо vegetаble fаrming. Beсаuse оf its рreсise сlimаtiс requirements fоr severаl рhysiоlоgiсаl рrосesses, the роtаtо is the mоst vulnerаble tо сlimаte сhаnge.
Capacidades territoriais do planejamento. Estado e sua influência no processo de urbanização brasileiro
Authors: Tavares Jeferson Cristiano
Published: October 2022

O objetivo central é problematizar o planejamento estatal brasileiro pelo seu aspecto territorial nas últimas três décadas e compreender algumas características predominantes do atual processo de urbanização. O presente artigo apresenta resultados de pesquisa sobre as políticas públicas urbanas pela perspectiva do planejamento tomando como objeto principal a provisão de infraestrutura de saneamento, mobilidade e habitação. Metodologicamente, a análise está baseada em uma investigação empírica sobre os investimentos federais realizados entre 1990 e 2019 e sobre os programas que os promoveram; e por uma visão interescalar a partir da espacialização desses dados nos municípios. Apoia-se nas teorias de políticas públicas para compreender o papel do Estado; e nos conceitos de metropolização e dispersão urbana para compreender sua capacidade no ordenamento territorial. Os resultados reforçam as tradicionais constatações sobre tensões e contradições desse ordenamento. Mas, trazem evidências de novos aspectos relacionados à dimensão urbano-regional, ao setorialismo, à capilaridade dessas ações e aos seus novos paradigmas. As conclusões apontam para um ciclo de investimentos cujos resultados relacionam-se às características do federalismo descentralizado e do processo de redemocratização que os empreenderam e respondem à questão principal de como o Estado intervém no ordenamento territorial e de como poderia intervir.
Arquitetura entre plano, truque e finta
Authors: Capillé Cauê , Cruz Mariana
Published: October 2022

Nesse artigo, argumentamos que uma conciliação racional pelo ‘plano’ é apenas um modo de atuação arquitetônica, isto é, há ao menos outros dois modos que podem ser considerados ao projetar: tanto o ‘truque’ dissimulado que dissocia declaração de operação; quanto a ‘finta’ que abertamente declara sua oposição, mas que ginga marginalmente como forma de desvia-la e vence-la. Além disso, defendemos que embora sejamos treinados majoritariamente para projetar por planos, os contextos e desafios urbanos contemporâneos têm nos exigido saber atuar por truques e fintas – especialmente nas condições políticas do Sul Global. Esse artigo pretende, portanto, auxiliar na construção teórica dessas duas outras maneiras de projetar. Para isso, revisa a proposta teórica de Keller Easterling sobre ‘hackeamento espacial’ e propõe que a obra de Cildo Meireles “Inserções em circuitos ideológicos” pode ser considerada como importante referência político/estética para o truque e a finta arquitetônicos, pois oferece lições para uma construção teórica sobre a diferença entre ambas.
Effect of Temperature Variations on Elevated Temperature Curing Method Towards Modulus of Elasticity and Compressive Strength of Normal Concrete With Additional Accelerator
Authors: Yuhanata Cierio , Nurtanto Dwi , Utami Nanin Meyfa
Published: October 2022

Developments in modern times have grown rapidly, this can be seen from the rapid development. Along with the increasing scale of development in the world of construction, more and more concrete is needed effectively, practically, and in the future. The strength of concrete is strongly influenced by the quality of the materials, admixtures, the working process, and the curing of the concrete. Concrete with the addition of an accelerator has higher compressive strength, this is due to the accelerator reaction which can accelerate the binding process and the development of the initial compressive strength of the concrete. Concrete with direct immersion treatment has large compressive strength. There are several methods of treating concrete, including watering and high temperature. This study used a fixed accelerator proportion of 3 % of the weight of cement with a test time of 7 and 28 days. The treatment method used is open space, immersion, high temperature at temperatures of 25 ºC, 30 ºC, 35 ºC, 40 ºC and 45 ºC. From the results of the research, there are differences in characteristics between normal concrete and concrete with the addition of an accelerator. Concrete with a high-temperature treatment method at a temperature of 45 ºC produces the highest strong pressure. This is caused by the higher the treatment temperature, the higher the rate of hydration process that affects the compressive strength of the concrete.
A problem with a non-local condition for a fourth-order equation with multiple characteristics
Authors: Bogatov Andrei V. , Gilev Anton V. , Pulkina Ludmila S.
Published: October 2022

In this article, we consider a non-local problem with an integral condition for a fourth-order equation. The unique solvability of the problem is proved. The proof of the uniqueness of a solution is based on the a priori estimates derived in the paper. To prove the existence of a solution, the problem is reduced to two Goursat problems for second-order equations, and the equivalence of the stated problem and the resulting system of Goursat problems is proved. One of the problems of the system is the classical Goursat problem. The second problem is a characteristic problem for an integro-differential equation with a non-local integral condition on one of the characteristics. It is impossible to apply the well-known methods of substantiating the solvability of problems with conditions on characteristics to the study of this problem. The introduction of a new unknown function made it possible to reduce the second problem to an equation with a completely continuous operator, to verify, on the basis of the uniqueness theorem, that it is solvable and, by virtue of the proven equivalence of the problems, that the problem posed is solvable.
Public Reasoning and the Role of Logos in Gorgias and Aristotle
Authors: Konrádová Veronika
Published: October 2022

This paper focusses on the role of public speech in the process of political deliberation and collective decision-making. Specifically, it pays attention to Gorgias and Aristotle’s reflection on the role of persuasive logos in the domain of public reasoning. The aim of this paper is to examine the common features of Gorgias and Aristotle’s understanding of the human condition and the ways of managing it in the context of social life. Gorgias’ fundamental contribution to this topic can be seen in his Encomium of Helen, a pioneering argument on the power of logos within the human world. On this basis, this paper clarifies the theoretical background of Gorgianic anthropology and highlights its sensitivity to the situational framework of human decision-making. Recognising the essential ambiguity of the human situation in the absence of an absolute measure of human action, sophistry advocates techniques of immanently controlling the world and recognises the key role of rhetoric communication in this process. In this context, Gorgias’ in-depth analysis reveals the power of speech in manifesting the relevant aspects of the situation, grasping current options and encouraging a proper response on the level of deeds. Aristotle can be compared with Gorgias precisely with respect to their shared sensitivity for the situational character of human deliberation and decision-making. Aristotle’s detailed account of individual deliberation in the varying constellations of particular situations (EN III 2-3) at the same time provides a suitable model for public deliberation. On the level of public reasoning, the role of logos becomes prominent again. The logos is effective within the contingent world where the future is uncertain and open to various possibilities. Grasping the optimum while respecting all unique circumstances, including the proper time for collective action that the community should take, defines the public debate. In this context, this paper examines Aristotle’s concept of deliberative rhetoric (Rhet. I 3-4). Special emphasis is placed on the fact that in the case of deliberative speech (unlike forensic speech), Aristotle admits using non-argumentative procedures such as appealing to one’s emotions, etc. His approach suggests that he does not understand political deliberation as an impartial assessment of neutral options, but as an engaged discussion about shared goals and the common good, which is influenced by the emotional attitudes of the interested members of the political community. For Aristotle, public reasoning remains a contest for attention and trust. Exploring these aspects allows evaluating Aristotle’s contribution to managing political reality through persuasive speech.
Nomos and Nous. Which Are Plato’s Criteria for the Definition of a Just City?
Authors: Migliori Maurizio
Published: October 2022

SIn Plato, two different visions of politics coexist: care of the soul and care of the polis. A second point is Plato’s systemic and holistic view. Every reality is a whole made up of parts that depend on the whole. Finally, the whole is a principle of order that has a rational foundation in the Ideas. Consequently, the action of the human being is and must be rational. The link between intelligence and law, underlined by the similarity of the two words, nous and nomos, is posed in various ways. The centrality of intelligent intervention clashes with the lack of credit that Plato gives to human action. The polis is marked by diversity and conflict. Human constitutions must use the laws, a rigid tool that, if imitate the paradigm, can counteract the prevalence of disorder. In Plato’s political philosophy the concept of imitation is fundamental. The ideal paradigm is useful for guilding the true politician in his rational effort to propose laws.

But this centrality of intelligent intervention clashes with the lack of credit that Plato gives to human action. When this action is positive, it is a sort of miracle. In fact, the polis is marked by diversity and, therefore, by the conflict.

In this situation Plato proposes a complex of ideal models: the first, a perfect model of polis in the Republic, and a second model in the Laws, that is similar to the first at the highest possible level, and a third, that Plato did not have time to write. These paradigms can be useful, but it is impossible to govern the state “in a scientific manner”. The human constitutions must use the laws, a rigid tool that, if imitate the paradigm, can counteract the prevalence of disorder. In Plato's political philosophy the concept of imitation is fundamental. The ideal paradigm is useful because it guides the true politician, in his rational effort to propose laws.

In summary, Plato does not have a utopian or abstract vision of politics. It is not possible to close him in an elementary and one-sided formula: its vision of human complexity, both personal and social, and its theoretical richness propose and require a structurally multifocal reading
Quando la buona legge è “curativa”
Authors: Fermani Arianna
Published: October 2022

El artículo pretende profundizar los vínculos entre ley (νόµος) y sabiduría (φρόνησις) en Aristóteles, mostrando que la “ley” o, mejor, la “buena” ley, está llamada a asumir un poder “curativo”, fundamental tanto para el individuo como para la comunidad. Tras cruzar las acepciones de ambos términos, νόµος y φρόνησις, y un breve repaso de los demás términos con los que los griegos denominaban a la propia ley, se analizan las articulaciones de la noción de sabiduría y se examina su relación con la justicia y la equidad, intercediendo también con la cuestión de la flexibilidad (con sus implicaciones epistemológicas y ético-políticas) y el cuidado (ἐπιµέλεια)
Factors Affecting the Incidence of Anemia in Pregnant Women at Ampel and Gladagsari Public Health Center Boyolali Regency in 2019
Authors: Davidson Sarah Melati , Mangalik Gelora , Riswandha Rifki Ilham
Published: October 2022

Background: Anemia is a condition where the blood hemoglobin level is <11 g/dl. Anemia is often experienced by mothers during pregnancy. The main cause of anemia in pregnant women is due to iron deficiency in the body. This study aims to determine what factors are the main causes of anemia in the working area of Ampel Health Center and Gladagsari Health Center. Poor nutritional status, parity, short pregnancy intervals are believed to be the biggest contributors to the incidence of anemia in pregnant women.

Methods: This study used secondary data with a cross sectional design. Chi Square test is used in statistical testing. Study involved Ampel Health Center (193 samples) and Gladagsari Health Center (246 samples). The variables studied were the age of pregnant women, distance between pregnancies, parity, nutritional status, Antenatal Care and adherence to Fe tablet consumption.

Results: The results showed that nutritional status (0.001), gestational distance (0.003), parity (0.032) and age of pregnant women (0.032) had a significant relationship with the incidence of anemia in Ampel Health Center < (0.05). Gladagsari Health Center samples showed different results where nutritional status (0.003), gestational distance (0.007), parity (0.005), adherence to Fe tablet consumption (0.049) and age of pregnant women (0.046) had a significant relationship with the incidence of anemia < (0, 05). Maternal nutritional status during pregnancy is the highest cause of anemia, many steps can be taken to improve the nutritional status of pregnant women, one of which is the provision of additional food.

Conclusion: Education of health workers about the importance of consuming Fe tablets for women of childbearing age (WUS) and pregnant women and self-compliance play an important role in preventing anemia during pregnancy.
Pengaruh Independensi, Pengalaman, dan Penerapan Teknik Audit Berbantuan Komputer (TABK) Terhadap Efektivitas Pelaksanaan Audit Investigatif Dalam Mendeteksi Kecurangan
Authors: Fauzi Mokhammad Ridwan , Choirul Anwar  , Ulupui I Gusti Ketut Agung
Published: October 2022

Abstract

 This study was conducted to obtain empirical evidence regarding the Effect of Independence, Experience, and Application of Computer Assisted Audit Techniques (TABK) on the Effectiveness of Investigative Audit Implementation in Detecting Fraud. This study uses primary data with a sample of investigative auditors working at the Central Office of the Indonesian Supreme Audit Board (BPK RI), Central Jakarta. The sampling technique uses a random sampling method with 55 respondents. Hypothesis testing uses multiple linear regression analysis method with a significance level of 5%. Based on the results of the analysis conducted, it can be concluded that partially, independence has a significant positive effect on the effectiveness of investigative audit in detecting fraud, experience has a significant positive effect on the effectiveness of investigative audit in detecting fraud, and the application of TABK has a significant positive effect on the effectiveness of investigative audit in detect fraud. Simultaneously, independence, experience, and application of TABK have a significant positive effect on the effectiveness of investigative audits in detecting fraud.

Abstrak

 Penelitian ini dilakukan untuk memperoleh bukti empiris mengenai Pengaruh Independesi, Pengalaman, dan Penerapan Teknik Audit Berbantuan Komputer (TABK) Terhadap Efektivitas Pelaksanaan Audit Investigatif Dalam Mendeteksi Kecurangan. Penelitian ini menggunakan data primer dengan sampel auditor investigatif yang bekerja di Kantor Pusat Badan Pemeriksa Keuangan Republik Indonesia (BPK RI) Jakarta Pusat. Teknik sampling menggunakan metode  random sampling dengan 55 responden. Pengujian hipotesis menggunakan metode analisis regresi linear berganda dengan tingkat signifikansi 5%. Berdasarkan hasil analisis yang dilakukan, dapat disimpulkan bahwa secara parsial, independensi berpengaruh positif signifikan terhadap efektivitas pelaksanaan audit investigatif dalam mendeteksi kecurangan, pengalaman berpengaruh positif signifikan terhadap efektivitas pelaksanaan audit investigatif dalam mendeteksi kecurangan, dan penerapan TABK berpengaruh positif signifikan terhadap efektivitas pelaksanaan audit investigatif dalam mendeteksi kecurangan. Secara simultan, independensi, pengalaman, dan penerapan TABK berpengaruh positif signifikan terhadap efektivitas pelaksanaan audit investigatif dalam mendeteksi kecurangan.
PENGARUH LDR, CAR, BOPO, DAN BANK SIZE TERHADAP ROA PADA BANK UMUM DI MASA PANDEMI COVID-19
Authors: Putri Rizkia Amelia , Hendra Sanjaya Kusno  , Juspa Parasi
Published: October 2022

Penelitian ini bertujuan untuk mengetahui pengaruh loan to deposit ratio, capital adequacy ratio, beban operasional pendapatan operasional, dan bank size terhadap bank return on assets pada umum yang terdaftar di Bursa Efek Indonesia periode 2019-2020. Data diperoleh dari laporan keuangan tahunan bank dan menggunakan 46 bank dengan total sampel 20 bank. Pengambilan data menggunakan metode purposive sampling dengan analisis data yang digunakan adalah analisis regresi linear. Teknik analisis yang digunakan untuk pengujian hipotesis berupa uji F dan uji t. Selain itu, juga digunakan uji asumsi klasik berupa uji normalitas, uji multikoliniearitas, uji autokorelasi, dan uji heteroskedastisitas. Hasil dari penelitian ini menyimpulkan bahwa, hasil uji hipotesis disimpulkan bahwa loan to deposit ratio, capital adequacy ratio, beban operasional dan pendapatan operasional, dan bank size berpengaruh simultan terhadap return on assets. Hasil uji parsial disimpulkan bahwa loan to deposit ratio, capital adequacy ratio, dan bank size tidak berpengaruh terhadap return on assets. Hasil uji parsial disimpulkan bahwa beban operasional pendapatan operasional berpengaruh negatif terhadap return on assets.
PENGARUH PENILAIAN KINERJA DAN BEBAN KERJA TERHADAP KINERJA PEGAWAI DENGAN MOTIVASI SEBAGAI VARIABEL MEDIASI PADA DIREKTORAT SISTEM INFORMASI DAN TEKNOLOGI PERBENDAHARAAN
Authors: Abdillah Novie Shol , Satrya Aryana , Priyati Rini Yayuk
Published: October 2022

Penelitian ini dilatarbelakangi oleh adanya hasil penilaian kinerja yang kurang memuaskan pada Direktorat Sistem Informasi dan Teknologi Perbendaharaan. Pada kenyataannya kinerja Direktorat SITP sudah banyak dirasakan oleh stake holder. Hal lain yang menjadi perhatian adalah adanya beban kerja yang besar namun tidak mengurangi motivasi pegawai untuk tetap memberikan hasil kinerja yang maksimal. Rumusan masalah pada penelitian ini adalah: (1) bagaimana pengaruh penilaian kinerja terhadap kinerja pegawai; (2) bagaimana pengaruh penilaian kinerja terhadap motivasi kerja karyawan; (3) bagaimana beban kerja mempengaruhi kinerja pegawai; (4) bagaimana beban kerja mempengaruhi motivasi kerja karyawan dan (5) bagaimana motivasi karyawan mempengaruhi kinerja karyawan. Penelitian ini merupakan penelitian kuantitatif. Pengumpulan data dilakukan dengan menyebarkan survei online kepada 135 staf Direktorat SITP pada seluruh Subdirektorat. Analisis data menggunakan model persamaan struktural atau Structural Equation Model (SEM) dengan pengolahan data menggunakan Partial Least Square (PLS) versi 3. Hasil penelitian menunjukkan bahwa: (1) penilaian kinerja berpengaruh positif dan signifikan terhadap kinerja karyawan; (2) penilaian kinerja berpengaruh positif dan signifikan terhadap motivasi kerja karyawan; (3) beban kerja berpengaruh positif dan signifikan terhadap kinerja pegawai; (4) beban kerja berpengaruh positif dan signifikan terhadap motivasi kerja pegawai dan (5) motivasi kerja memberikan mediasi parsial antara penilaian kinerja dan beban kerja terhadap kinerja pegawai.
PERHATIAN INVESTOR DAN LIKUIDITAS SAHAM PERUSAHAAN PUBLIK DI BURSA EFEK INDONESIA
Authors: Usman Berto , Afandy Chairil , Zoraya Intan
Published: October 2022

Signifikannya geliat internet di Indonesia membuat kontribusi internet (Google) sebagai media perantara penyampaian informasi ke publik menjadi sarana yang semakin diminati. Hal ini menjadi relevan karena andil internet terhadap perkembangan ekonomi Indonesia juga tercatat sebagai determinan yang penting. Oleh sebab itu, penelitian ini bermaksud menguji peran Internet yang dapat dianalogikan sebagai representasi dari perhatian investor, dan menghubungkannya dengan likuiditas saham perusahaan publik yang diperdagangkan di Bursa Efek Indonesia (BEI). Dengan menggunakan basis teori asimetri informasi, penelitian ini juga mengkaji secara empiris upaya mitigasi terhadap kesenjangan informasi antara investor terinformasi (informed) vs. investor tidak terinformasi (uninformed). Secara operasional, penelitian ini menggunakan sampel dari 82 perusahaan publik di BEI dengan periode waktu pengamatan bulanan dari bulan Januari 2013 sampai dengan Desember 2017. Dengan karakteristik dan struktur data panel, maka penelitian ini menggunakan analisis regresi panel dengan jumlah data sebesar 4,920 observasi (perusahaan-bulan). Analisis yang digunakan juga menerapkan fixed-effect model (FEM) pada level perusahaan (firm-FE) dan tahun (Month-FE), yang disertai dengan clustered SE guna mengantisipasi potensi overestimasi pada nilai standard error (SE). Hasil penelitian menunjukkan bahwa terdapat asosiasi yang positif antara perhatian investor yang diwakili oleh GSV (Google Search Volume) dengan likuiditas saham perusahaan, TV (Trading Volume). Implikasi dari temuan ini menunjukkan bahwa stakeholder (investor) dapat mempergunakan informasi publik yang tersedia dan didistribusikan melalui internet untuk mereduksi tingkat asimetri informasi yang terjadi antara informed vs. uninformed investor di pasar modal.
PENGARUH KUALITAS PELAYANAN TERHADAP LOYALITAS TAMU MELALUI KEPUASAN TAMU (Studi Kasus di Favehotel Gatot Subroto Jakarta)
Authors: Hutagalung Dody Andreas , Nafiah Ariyani  , Entas Derinta
Published: October 2022

Manajemen hotel perlu menciptakan loyalitas tamu di tengah ketatnya persaingan bisnis hotel saat ini. Penelitian ini bertujuan untuk menganalisis dan mengetahui bagaimana kualitas pelayanan dapat mempengaruhi loyalitas tamu melalui kepuasan tamu. Penelitian ini dilakukan di Favehotel Gatot Subroto, Jakarta. Penelitian ini menggunakan pendekatan kuantitatif. Populasi penelitian adalah tamu yang menginap di hotel minimal dua kali, yang menggunakan teknik non-probability purposive sampling dengan jumlah sampel sebanyak 179 responden. Instrumen penelitian ini menggunakan kuesioner yang telah diuji validitas dan reliabilitasnya. Hasil kuesioner dianalisis dengan Structural Equation Modelling-Partial Least Square (SEM-PLS). Hasil penelitian menunjukkan adanya pengaruh yang kuat dan positif antara variabel kualitas pelayanan dengan kepuasan tamu (kualitas pelayanan dapat menjelaskan kepuasan tamu sebesar 62%). Hasil lain dari penelitian ini juga terdapat pengaruh yang kuat dan positif antara variabel kualitas pelayanan terhadap loyalitas tamu melalui kepuasan tamu, dimana kualitas pelayanan dapat menjelaskan loyalitas tamu melalui kepuasan tamu sebesar 77,6%. Hasil penelitian manajemen manfaat dalam meningkatkan kualitas pelayanan dan kepuasan tamu untuk meningkatkan loyalitas pelanggan
Design and Build 2D Android-based Adventure Game “Excuse Me”
Authors: Kholis Muhammad Nur , Taurusta Cindy , Astutik Ika Ratna Indra
Published: October 2022

Manners are a must for a child as basic education from an early age. Learning manners should be taught in childhood starting with an introduction to simple manners and manners. This encourages the idea to create a game that can be used as a tool in teaching etiquette for early childhood. Learning methods accompanied by play will make it easier for children to understand things easily. This educational game is entitled "excuse me" with a 2D adventure genre where a story is presented about a little boy who wants to return to his house after school, but on the way, he meets many obstacles. The little boy must pass through one after another in order to return to his home safely. This game has 5 levels and each level has different obstacles. The game framework development in this research uses the Unity 3D game engine to build android based games. The advantage of the "excuse me" game is that this game can be a more interactive and interesting learning method and can make players feel that etiquette is very important in everyday life and in the game. and the disadvantages of this game are that it cannot run on the iOS operating system, lacks levels, and has an unattractive interface. Responses from children aged 13 and over indicated that the media was "very interesting".
Detection of the continuous gravitational wave of HM Cancri
Authors: Weidner Herbert
Published: October 2022

HM Cancri is expected to be be one of the brightest sources of gravitational waves in our galaxy. Despite its known frequency, the radiation could not be detected so far. A new method eliminates the strong phase modulation caused by the earth's orbit and drastically reduces the bandwidth. Therefore, the GW can be easily identified in the records of numerous superconducting gravimeters. The determined parameters of the GW agree very well with the results of previous observations of the double star system in the X-ray range.
Intrathecal magnesium delivery for Mg++-insensitive NMDA receptor activity due to GRIN1 mutation
Authors: Lewis Sara A. , Shetty Sheetal , Gamble Sean , Heim Jennifer , Zhao Ningning , Stitt Gideon , Pankratz Matthew , Mangum Tara , Marku Iris , Rosenberg Robert B. , Wilfong Angus A. , Fahey Michael C. , Kim Sukhan , Myers Scott J. , Appavu Brian , Kruer Michael
Published: October 2022

Background
Mutations in the NMDA receptor are known to disrupt glutamatergic signaling crucial for early neurodevelopment, often leading to severe global developmental delay/intellectual disability, epileptic encephalopathy, and cerebral palsy phenotypes. Both seizures and movement disorders can be highly treatment-refractory.
Results
We describe a targeted ABA n = 1 patient trial with intrathecal MgSO4, rationally designed based on the electrophysiologic properties of this gain of function mutation in the GRIN1 NMDA subunit.
Conclusion
Although the invasive nature of the trial necessitated a short-term, non-randomized, unblinded intervention, multimodal neurophysiologic monitoring indicated benefit, providing class II evidence in support of intrathecal MgSO4 for select forms of GRIN disorders.
Effect of Remdesivir on moderate to severe COVID-19 patients’ outcomes.
Authors: Aboelsaad Iman , Ashmawy Rasha , Mahrous Doaa , Sharaf Sandy , Aly Shahinda , Abdullatif Sara , Fakhry Ayat , Hassan Basma , Khamis Dalia , Aldakhs Alaa , Kamal Ehab
Published: October 2022

Background: Remdesivir is a broad-spectrum antiviral that has been approved as promising medicine worldwide for the fatal pandemic COVID-19 disease. There is a debate over its efficacy, with different studies taking into account a variety of factors. Therefore, we conducted this study to evaluate the primary composite outcome of mortality rate, need for mechanical ventilation, and escalation of care among Remdesivir (RDV) and non-Remdesivir (NoRDV) groups.
Methods: Patients with moderate and severe COVID-19, as confirmed by the CPR, were observed retrospectively, before and after including remdsivir in the treatment protocol in the period from August 2020 to February 2021.
Result: From the 509 hospitalized patients, 35% received Remdesivir, with 64% being severe patients. The median age in both groups was 59 years old, and there was no significant difference between the two groups regarding gender, baseline characteristics, and comorbidities. In contrast, the median hospital length of stay in the RDV group was lower (8 days) than in the RDV group (8 days) than the NoRDV (9 days), P= 0.004.
The composite outcome was 17.7% in the RDV group and 22.2% in the NoRDV group, but the difference was statistically insignificant (p-value 0.289). Adjusted logistic regression demonstrated a non-significant lower association of the composite outcome with RDV use (OR 0.623, 95CI% 0.37-1.02), and a significant reduction occurred in patients <60 years old (OR 0.39, 95%CI 0.17 – 0.83). However, survival analysis for mortality, MV, and transfer to a higher level revealed insignificant differences in the median time between groups. Subgroup analyses showed that RDV utilization had a non-significant effect on the risk of all three outcomes across different groups.
Conclusion: Despite controlling all patient characteristics, treatment with RDV did not improve patient outcomes over other antivirals and standard care. There is an urgent need for further studies to investigate and evaluate new therapeutic approaches or combinations.
Three new species of Trichoderma from soils in China
Authors: Zhao Rui , Mao Li-Juan , Zhang Chu-Long
Published: October 2022

Trichoderma spp. are diverse fungi with wide distribution. In this study, we report three new species of Trichoderma, named as T. nigricans, T. densissimum and T. paradensissimum, which were collected from soils in Shandong, Shanxi and Shannxi provinces of China. Their description is based on morphology and phylogenetic analyses. Subsequent phylogenetic analysis and pairwise similarity calculation were conducted using two DNA barcode loci, the second largest nuclear RNA polymerase subunit encoding gene (rpb2) and the translation elongation factor 1- alpha encoding gene (tef 1), respectively, based on the analysis of the primary barcode locus, internal transcribed spacer (ITS) of the ribosomal DNA. The pairwise similarities of tef1 and rpb2 showed that all of them meet the Trichoderma new species standard. In the phylogenetic analysis, each new species formed a distinct clade: T. nigricans is a new member of the Atroviride Clade, and T. densissimum and T. paradensissimum belong to the Harzianum Clade. Compared with closely related species, T. nigricans is characterized by its growth, chlamydospores and odor; T. densissimum is easily distinguished by its relatively large chlamydospores; T. paradensissimum can be recognized by the green to yellow and inconspicuously zonate white pustules formed on PDA or MEA.
Amburana cearensis seed extract stimulates astrocyte glutamate homeostatic mechanisms in hippocampal brain slices and protects oligodendrocytes against ischemia
Authors: Ferreira Rafael Short , Ribeiro Paulo Roberto , Silva Juliana Helena Castro e , Hoppe Juliana Bender , Almeida Monique Marylin Alves , Ferreira Beatriz Correia Lima , Andrade Gustavo Borges , Souza Suzana Braga , Ferdandez Luzimar Gonzaga , Costa Maria de Fátima Dias , Salbego Christianne Gazzana , Rivera Andrea Domenico , Longoni Aline , De Assis Adriano Martimbianco , Pieropan Francesca , Moreira José Cláudio Fonseca , Costa Silvia Lima , Butt Arthur Morgan , Silva Victor Diogenes Amaral
Published: October 2022

Background.
Stroke is a leading cause of death and disability worldwide. A major factor in brain damage following ischemia is excitotoxicity caused by elevated levels of the neurotransmitter glutamate. In the brain, glutamate homeostasis is a primary function of astrocytes. Amburana cearensis has long been used in folk medicine and seed extract obtained with dichloromethane (EDAC) have previously been shown to exhibit cytoprotective activity in vitro. The aim of the present study was to analyse the activity of EDAC in hippocampal brain slices.
Methods.
We prepared a dichloromethane extract (EDAC) from A. cearensis seeds and characterized the chemical constituents by 1H and 13C-NMR. Hippocampal slices from P6-8 or P90 Wistar rats were used for cell viability assay or glutamate uptake test. Hippocampal slices from P10-12 transgenic mice SOX10-EGFP and GFAP-EGFP and immunofluorescence for GS, GLAST and GLT1 were used to study oligodendrocytes and astrocytes.
Results.
Astrocytes play a critical role in glutamate homeostasis and we provide immunohistochemical evidence that in excitotoxicity EDAC increased expression of glutamate transporters and glutamine synthetase, which is essential for detoxifying glutamate. Next, we directly examined astrocytes using transgenic mice in which glial fibrillary acidic protein (GFAP) drives expression of enhanced green fluorescence protein (EGFP) and show that glutamate excitotoxicity caused a decrease in GFAP-EGFP and that EDAC protected against this loss. This was examined further in the oxygen-glucose deprivation (OGD) model of ischemia, where EDAC caused an increase in astrocytic process branching, resulting in an increase in GFAP-EGFP. Using SOX10-EGFP reporter mice, we show that the acute response of oligodendrocytes to OGD in hippocampal slices is a marked loss of their processes and EDAC protected oligodendrocytes against this damage.
Conclusion.
This study provides evidence that EDAC is cytoprotective against ischemia and glutamate excitotoxicity by modulating astrocyte responses and stimulating their glutamate homeostatic mechanisms.
Breakdown of the scaling relation of anomalous Hall effect in Kondo lattice ferromagnet USbTe
Authors: Siddiquee Hasan , Broyles Christopher , Kotta Erica , Liu Shouzheng , Peng Shiyu , Kong Tai , Kang Byungkyun , Zhu Qiang , Lee Yongbin , Ke Liqin , Weng Hongming , Denlinger Jonathan , Wray L. Andrew , Ran Sheng
Published: October 2022

The interaction between strong correlation and Berry curvature is an open territory of in the field of quantum materials. Here we report large anomalous Hall conductivity in a Kondo lattice ferromagnet USbTe which is dominated by intrinsic Berry curvature at low temperatures. However, the Berry curvature induced anomalous Hall effect does not follow the scaling relation derived from Fermi liquid theory, and has a strong temperature dependence. The onset of the Berry curvature contribution to the anomalous Hall effect coincides with the Kondo coherent temperature. Combined with ARPES measurement and DMFT calculations, this strongly indicates that Berry curvature is hosted by the flat bands induced by Kondo hybridization at the Fermi level. Our results demonstrate that the Kondo coherence of the flat bands has a dramatic influence on the low temperature physical properties associated with the Berry curvature, calling for new theories of scaling relations of anomalous Hall effect to account for the interaction between strong correlation and Berry curvature.