bluuebunny/crossref_metadata_2025 huggingface dataset:
“The Rocket”: Newspaper Coverage of the Death of a Québec Cultural Icon, A Canadian Hockey Player
Authors: Ramos Howard , Gosine Kevin
Published: December 2016

Through a systematic analysis of the English and French newspaper coverage of the May 2000 death of ice hockey great Maurice “the Rocket” Richard, this paper explores the cultural divide that continues to exist between Québec and the rest of Canada. We find that the French Québec media used the death to reassert the prevailing représentation of Richard as a Symbol of francophone identity and nationalism. For their part, the English Canadian media were willing to surrender this particular hockey legend to French Québec. The findings point to an enduring cultural gulf between Canada’s two solitudes that even the supposedly unifying Symbol of hockey cannot transcend. The analysis also provides insight into how the media construct shared meaning for a defensively situated collectivity, as well as how such counter-hegemonic media discourses are received and negotiated by a dominant community.
Long time semiclassical Egorov theorem for ℏ-pseudodifferential systems
Authors: Assal Marouane
Published: December 2016

In the Heisenberg picture, we study the semiclassical time evolution of a bounded quantum observable [Formula: see text] associated to a [Formula: see text] matrix-valued symbol Q generated by a semiclassical matrix-valued Hamiltonian [Formula: see text]. Under a non-crossing assumption on the eigenvalues of the principal symbol [Formula: see text] that ensures the existence of almost invariant subspaces of [Formula: see text], and for a class of observables that are semiclassically block-diagonal with respect to the projections onto these almost invariants subspaces, we establish a long time matrix-valued version for the semiclassical Egorov theorem valid in a large time interval of Ehrenfest type [Formula: see text].
Seeking an expanded, multidimensional conceptual approach to health literacy and health disparities research
Authors: Logan Robert A.
Published: December 2016

This chapter compares the conceptual foundations of health literacy and health disparities. It details some of the conceptual differences between health literacy and health disparities and explains some similarities that suggest the need for increased research collaboration. The chapter is among the first to address the structural and social determinants of health together and explain that future research needs to assess their interaction.

Overall, the chapter creates a conceptual foundation as well as challenges future scholars/practitioners to take more multidimensional approaches to assess health’s determinants. The chapter also attempts to demonstrate there is nothing more practical than good theory, or clear conceptual foundations.

The chapter is divided into four sections that address the following topics: three conceptual frameworks about the determinants of health; opportunities in health disparities and health literacy research; seeking an expanded, multidimensional conceptual approach to health literacy and health disparities research; as well as a conclusion. The chapter suggests there are vacuums in current research knowledge that need future attention – especially regarding the integration of health literacy and health disparities research.
Sustaining the growth of library scholarly publishing in a New University Press
Authors: Stone Graham
Published: December 2016

In 2012, the University of Huddersfield Press presented a paper at the 16th International Conference on Electronic Publishing on its new open access journals platform. At the time, the Press was one of the only New University Presses (NUP) in the UK and one of the first to publish open access journals, open access monographs and sound recordings. This article discusses a number of emerging business models for NUPs before developing Hahn’s programme and publication level business plan, which is then related to the sustainability of the Press at Huddersfield. The article will demonstrate how the Press is able to show value to the University in order to secure funding. The paper will conclude with a discussion around the need for collaboration between library-led NUPs. Although this paper concentrates on the experiences of the University of Huddersfield Press, it will be relevant to other emerging or planned NUPs.
Article processing charges: A new route to open access?
Authors: Beasley Gerald
Published: December 2016

Article Processing Charges (APCs) have recently been studied as a means towards a sustainable Open Access (OA) environment for scholarly communications. However, APCs at any level represent a substantial economic barrier to the authors, institutions, funding agencies and governments that many of its advocates most wish to serve through OA initiatives. This paper claims that no business model based on APCs as a tool to facilitate the large-scale transition to OA can navigate the ethical dilemmas identified by political philosophers as appropriate for the kind of global environment in which scholarly publishing operates.
Research data centre services for complex software environments in the humanities
Authors: Bingert Sven , Buddenbohm Stefan
Published: December 2016

Research data is – regardless its disciplinary provenance – very heterogeneous in terms of data formats, applied research methods and content. In contrast to publications, a much broader spectrum of data representations has to be considered by research data infrastructures. Within the Humanities Data Centre project (HDC) an initial service portfolio for research data from the humanities has been developed in its design phase (2014–2016). Not only does this service portfolio has to facilitate the re-use of research data by third parties, a service anybody would expect as conventional for a research data centre, but it also has to provide novel benefits for the providers of research data to promote their contribution of data, documentation and support.

As an example for these intended benefits for research data providers we will introduce two service components: the application preservation and the referencing of complex software environments. Jointly applied they enable researchers to archive and reference to complex representations of research data such as digital editions, virtual research environments, or data visualisations.
The bi-objective workflow satisfiability problem and workflow resiliency
Authors: Crampton Jason , Gutin Gregory , Karapetyan Daniel , Watrigant Rémi
Published: December 2016

A computerized workflow management system may enforce a security policy, specified in terms of authorized actions and constraints, thereby restricting which users can perform particular steps in a workflow. The existence of a security policy may mean that a workflow is unsatisfiable, in the sense that it is impossible to find a valid plan (an assignment of steps to authorized users such that all constraints are satisfied). Work in the literature focuses on the workflow satisfiability problem, a  decision problem that outputs a valid plan if the instance is satisfiable (and a negative result otherwise).

In this paper, we introduce the Bi-Objective Workflow Satisfiability Problem (BO-WSP), which enables us to solve optimization problems related to workflows and security policies. In particular, we are able to compute a “least bad” plan when some components of the security policy may be violated. In general, BO-WSP is intractable from both the classical and parameterized complexity point of view (where the parameter is the number of steps). We prove that computing a Pareto front for BO-WSP is fixed-parameter tractable (FPT) if we restrict our attention to user-independent constraints. This result has important practical consequences, since most constraints of practical interest in the literature are user-independent.

Our proof is constructive and defines an algorithm, the implementation of which we describe and evaluate. We also present a second algorithm to compute a Pareto front which solves multiples instances of a related problem using mixed integer programming (MIP). We compare the performance of both our algorithms on synthetic instances, and show that the FPT algorithm outperforms the MIP-based one by several orders of magnitude on most instances.

Finally, we study the important question of workflow resiliency and prove new results establishing that known decision problems are fixed-parameter tractable when restricted to user-independent constraints. We then propose a new way of modeling the availability of users and demonstrate that many questions related to resiliency in the context of this new model may be reduced to instances of BO-WSP.
Analyse réaliste du jugement juridique
Authors: Brunet Pierre
Published: December 2016

L’analyse du jugement juridique par ce que l’on appelle le réalisme juridique entend souligner la dimension subjective qu’implique l’acte de juger et la part importante de pouvoir discrétionnaire dont bénéficient les juges. Néanmoins, loin de verser dans une analyse psychologisante et naïve, le réalisme d’hier et celui d’aujourd’hui sollicitent les outils et exploitent les résultats que les autres sciences sociales leur offrent pour mettre en évidence la complexité du jugement juridique qui ne saurait être réduit à une opération purement logique et déductive ni avoir l’ampleur d’une argumentation philosophique.
Transmissions familiales culturelles et sexuées. Les effets sur les processus d’intégration sociale des descendants de migrants maghrébins
Authors: Tatu-Colasseau Anne
Published: December 2016

En contexte d’héritage migratoire, le rôle des transmissions familiales mémorielles et culturelles sur les processus d’intégration sociale des descendants peut être questionné. Dans cet article, nous étudions cet objet dans le cas particulier des migrations maghrébines. Dans une perspective de sociologie compréhensive, une modélisation idéale-typique tente d’appréhender les différents modes de transmissions familiales intergénérationnelles et leurs effets sur l’intégration sociale différenciée des filles et des garçons. L’analyse se centre, dans un premier temps, sur la transmission des origines en lien avec le projet migratoire puis, dans un deuxième temps, sur celle de la mémoire biographique transmise en lien avec le statut sexué du transmetteur. Il en ressort à la fois le rôle décisif des transmissions culturelles et biographiques, le statut pivot des mères dans ces transmissions et le bénéfice plus marqué de ces dernières sur les parcours d’intégration des filles.
Justice familiale et migration : de la diversité culturelle à la double appartenance
Authors: Wyvekens Anne
Published: December 2016

À partir d’une enquête menée dans deux tribunaux de grande instance, l’article se propose de montrer comment la justice familiale, lorsqu’elle est confrontée à des justiciables immigrés ou d’origine immigrée, met en scène, plus qu’une différence entre « eux » et « nous », une double appartenance, produit complexe de la migration. Annulations de mariage et changements de prénom font voir des justiciables qui sont à la fois d’ici et d’ailleurs. Quant aux magistrats, ils abordent ces situations en naviguant entre un traitement pragmatique – relativement indifférent aux différences – des situations individuelles, et des représentations parfois suspicieuses de l’immigration en tant que phénomène collectif.
Introduction : génétique et théâtre
Authors: Simonet-Tenant Françoise
Published: December 2016

Après avoir rappelé les étapes qui ont permis au domaine de la « critique génétique » de se formuler, Françoise Simonet-Tenant récapitule ici les caractéristiques spécifiques de la genèse théâtrale. Le texte et la représentation s’organisent en effet souvent ensemble. Dès lors, le nombre d’intervenants dans l’élaboration de la pièce augmente et ne se cantonne plus seulement à « l’auteur », et la chronologie préparatoire de la pièce se révèle plus difficile à tracer. Celle-ci semble être en fait toujours dans un état transitoire, à renouveler sans cesse au gré des représentations successives.
D’une langue à l’autre
Authors: Kattan Naïm
Published: December 2016

Conférence-témoignage de l’écrivain canadien d’origine irakienne, Naïm Kattan sur son expérience théâtrale de spectateur et de dramaturge.
Sex, Lies et les Franco-Manitobains de Marc Prescott : de l’esclandre étudiant (1993) au classique avant-gardiste (2013)
Authors: Ladouceur Louise
Published: December 2016

Louise Ladouceur analyse ici le cas d’une pièce de théâtre de Marc Prescott, un dramaturge bilingue de l’Ouest canadien, maîtrisant à la fois le français et l’anglais. La pièce étudiée met en scène une parole mêlant ces deux langues, ainsi qu’on peut l’entendre dans le Manitoba contemporain (1993-2013). C’est toute la relation entre les deux langues et les deux communautés dans cette région de l’Ouest du Canada qui est donc mise en question ici. L’étude des différentes révisions du texte entre les représentations de 1993, à Saint-Boniface au Manitoba, et de 2013, au Québec, permet de comprendre tous les enjeux politiques, sociaux et culturels que recouvre cette question d’un « bilinguisme » affiché mais plus ou moins bien assumé. Les différentes révisions du texte en fonction des publics concernés (le Manitoba, le Québec) montrent aussi comment dans différentes régions francophones du Canada se joue le rapport aux deux langues officielles du pays.
« Ces belles voix à la dérive » : Jules Supervielle et le désir de théâtre
Authors: Davaille Florence
Published: December 2016

Florence Davaille étudie ici certains aspects de la genèse d’une pièce de théâtre de Jules Supervielle, Bolivar, jouée en 1936 à la Comédie-Française et reprise sous la forme d’un opéra en 1950. L’objectif est de montrer ce qui est au cœur des ré-écritures successives : incarner des voix dans des personnages, geste de création fondateur dans l’ontologie développée par Supervielle dès l’écriture de sa poésie. Au-delà du passage d’un genre à un autre, le choix d’écrire du théâtre chez Supervielle se révèle être l’étape ultime d’une « poétique de l’incarnation », ce qui rend cet aspect de son œuvre important, même s’il s’agit d’un théâtre très peu connu aujourd’hui.
Epigenetic and Transcriptional Regulation of IRAK-M Expression in Macrophages
Authors: Lyroni Konstantina , Patsalos Andreas , Daskalaki Maria G. , Doxaki Christina , Soennichsen Birte , Helms Mike , Liapis Ioannis , Zacharioudaki Vassiliki , Kampranis Sotirios C. , Tsatsanis Christos
Published: December 2016

During macrophage activation, expression of IL-1R–associated kinase (IRAK)-M is induced to suppress TLR-mediated responses and is a hallmark of endotoxin tolerance. Endotoxin tolerance requires tight regulation of genes occurring at the transcriptional and epigenetic levels. To identify novel regulators of IRAK-M, we used RAW 264.7 macrophages and performed a targeted RNA interference screen of genes encoding chromatin-modifying enzymes, signaling molecules, and transcription factors involved in macrophage activation. Among these, the transcription factor CCAAT/enhancer binding protein (C/EBP)β, known to be involved in macrophage inactivation, was necessary for the induction of IRAK-M expression. Chromatin immunoprecipitation showed that C/EBPβ was recruited to the IRAK-M promoter following LPS stimulation and was indispensable for IRAK-M transcriptional activation. Among histone 3–modifying enzymes, our screen showed that knockdown of the histone 3 lysine 27 (H3K27) methyltransferase and part of the polycomb recessive complex 2, enhancer of Zeste 2, resulted in IRAK-M overexpression. In contrast, knockdown of the H3K27 demethylase ubiquitously transcribed tetratricopeptide repeat X chromosome suppressed the induction of IRAK-M in response to LPS stimulation. Accordingly, we demonstrated that H3K27 on the IRAK-M promoter is trimethylated in unstimulated cells and that this silencing epigenetic mark is removed upon LPS stimulation. Our data propose a mechanism for IRAK-M transcriptional regulation according to which, in the naive state, polycomb recessive complex 2 repressed the IRAK-M promoter, allowing low levels of expression; following LPS stimulation, the IRAK-M promoter is derepressed, and transcription is induced to allow its expression.
The MHC Class II Immunopeptidome of Lymph Nodes in Health and in Chemically Induced Colitis
Authors: Fugmann Tim , Sofron Adriana , Ritz Danilo , Bootz Franziska , Neri Dario
Published: December 2016

We recently described a mass spectrometry–based methodology that enables the confident identification of hundreds of peptides bound to murine MHC class II (MHCII) molecules. In this article, we describe its application to the characterization of MHCII-bound peptides isolated from lymph nodes (LNs) of C57BL/6 mice. More than 1000 peptides could be identified in individual analyses, allowing a direct comparison of the MHCII peptidome in different types of normal LNs or in animals with colitis. The peptide length distribution and consensus sequences in axillary, brachial, inguinal, and mesenteric LNs were virtually identical, and a substantial portion of identified peptides corresponded to proteins found in all LNs. However, skin-specific proteins Sbsn and Dmkn and intestine-specific proteins Dmbt1, Krt19, and Maoa, among others, were exclusively identified in skin-draining and mesenteric LNs, respectively. Differences in peptide-presentation patterns were also observed when comparing healthy mice and mice with dextran sodium sulfate–induced colitis. Peptides derived from a subset of proteins (including IgE, Bank1, chondroitin sulfate synthase 2, Cmip, and Fth1) were exclusively identified in mice with colitis, revealing changes in the peptidome associated with the inflammatory process, as well as activation and clonal expansion of B cells.
TTLL12 Inhibits the Activation of Cellular Antiviral Signaling through Interaction with VISA/MAVS
Authors: Ju Lin-Gao , Zhu Yuan , Lei Pin-Ji , Yan Dong , Zhu Kun , Wang Xiang , Li Qing-Lan , Li Xue-Jing , Chen Jian-Wen , Li Lian-Yun , Wu Min
Published: December 2016

Upon virus infection, host cells use retinoic-acid–inducible geneI I (RIG-I)–like receptors to recognize viral RNA and activate type I IFN expression. To investigate the role of protein methylation in the antiviral signaling pathway, we screened all the SET domain–containing proteins and identified TTLL12 as a negative regulator of RIG-I signaling. TTLL12 contains SET and TTL domains, which are predicted to have lysine methyltransferase and tubulin tyrosine ligase activities, respectively. Exogenous expression of TTLL12 represses IFN-β expression induced by Sendai virus. TTLL12 deficiency by RNA interference and CRISPR-gRNA techniques increases the induced IFN-β expression and inhibits virus replication in the cell. The global gene expression profiling indicated that TTLL12 specifically inhibits the expression of the downstream genes of innate immunity pathways. Cell fractionation and fluorescent staining indicated that TTLL12 is localized in the cytosol. The mutagenesis study suggested that TTLL12’s ability to repress the RIG-I pathway is probably not dependent on protein modifications. Instead, TTLL12 directly interacts with virus-induced signaling adaptor (VISA), TBK1, and IKKε, and inhibits the interactions of VISA with other signaling molecules. Taken together, our findings demonstrate TTLL12 as a negative regulator of RNA-virus–induced type I IFN expression by inhibiting the interaction of VISA with other proteins.
Postcolonial Psychosis and Recovery Process in Osita Ezenwanebe’s Withered Thrust and Helon Habila’s Measuring Time
Authors: Adeyemi Olusola Smith , Bisiriyu Adeyemi Kabir , Felicia Abarowei
Published: December 2016

A dialectical study of the histories of colonization according to scholars like Mohan (2012), Ashcroft (1989) and Bhoemer (1993) are the histories of the collisions between the natives and the European communities, and since colonization involves direct territorial appropriation of another geopolitical entity, combined with forthright exploitation, appropriated cultural power with political sagacity, colonized nations are bound to be subjected to the position of inferior. The outcome of this conflict leads to the emergence of postcolonial theory, whose multiple discourses and trajectories, significations and positional ties has made its conceptualization difficult. Nonetheless as a set of unstable formations, it claims as its special provenance the terrain that in an earlier day used to go by the term ‘Third World’, describing the emergence of new cultural productions as a result of colonized-colonial relations. This paper however discusses the problems the colonized nations faced after the expiration of the so-called colonialism and through the study of Osita Ezenwanebe’s Withered Thrust and Helon Habila’s Measuring Time the paper reveals the postcolonial psychosis encountered by nations that have undergone the experience of colonial rule.
On the Creative Edge: The Artistic Side of One Library
Authors: Fletcher Mary
Published: December 2016

Libraries can go beyond being places of information to become places of inspiration. Years ago, at the Avon Free Public Library in Connecticut, we began offering creative art for children. These sessions were so successful that a room in the library was redesigned exclusively for creating art. Today, we have one of the first creative art studios located in a public library in the country.
Filmtastic! Teens Learn Filmmaking Skills with Kid Film Lab
Authors: O’Connor Shannon
Published: December 2016

Knowing what a powerful artistic medium filmmaking can be for youth, the Edith B. Ford Memorial Library in Ovid, New York, created a Kid Film Lab Project thanks to a Curiosity Creates grant. With the substantial monies, we were able to afford to purchase the necessary equipment and hire quality instructors to help run a successful program.
Grief in Picturebooks: An Evaluative Rubric
Authors: Von Drasek Lisa
Published: December 2016

Every young child experiences loss. From the first time her mother leaves the room, a typically developing child has no framework to process what Piaget has labeled “object permanence.”1 Mothers or fathers who have removed themselves physically from the sight of a baby have disappeared. Thus we witness the inconsolable sobbing child at daycare drop-off whose parent is “gone!”
An Artists’ Utopia: Creating “Artopia” at the Library
Authors: Candia Lauren
Published: December 2016

What can you do with yarn and some tempera paint? A water cannon and acrylic paint? Clay and Perler beads? At the Ontario City (CA) Library, kids ages 5 through 12 are challenged to stretch their creative muscles with unconventional art materials.
From the Chair: GODORT's Future: Developing an Approach for Implementation
Authors: Woods Stephen
Published: December 2016

Purpose is an essential part of every healthy organization and a critical factor for every individual. When an individual’s purposes align with an organizations, it can be a powerful and fulfilling experience. However, it is rarely the case that the individual and the organization start out in complete agreement. It is in the process of aligning that satisfaction and meaning find their synergy.
GODORT Annual Conference Highlights
Authors: Round Table Government Documents
Published: December 2016

GODORT Steering IGeneral Membership MeetingGODORT Steering IISummary of Legislation Committee Actions at ALA Midwinter 2016, BostonGODORT Federal Documents Task Force (FDTF)GODORT International Documents Task Force (IDTF)GODORT State and Local Government Documents Task Force (SLDTF)GODORT Bylaws and Organization CommitteeGODORT Cataloging CommitteeGODORT Government Information for Children CommitteeGODORT Membership CommitteeGODORT Program CommitteeGODORT Publications CommitteeGODORT Rare and Endangered Government Publications CommitteePreservation Working GroupGODORT Preservation Working GroupGODORT Education Committee
From the Chair: Some Last Thoughts on Leadership, Tradition and Change
Authors: Woods Stephen
Published: December 2016

My daughter’s high school recently did a wonderful production of the classic musical, Fiddler on the Roof. It’s a timeless message of a father’s love and devotion for his daughters in the midst of incredible cultural and political change. I’ve seen this musical many times in my life, but I was struck afresh with the incredible tension Tevye felt as a father between “what was expected” and the future happiness of his daughters.
State and Local: Capturing the Moment: Local Government Publications
Authors: Laster Shari , Quinn Aimée C.
Published: December 2016

When it comes to identifying and accessing government information sources, publications from local government offices and departments can be one of the toughest areas out there. Local or municipal governments are typically categorized based on the category of government subdivision they fit, such as counties, cities, towns, or districts, but they are more frequently requested and accessed based on the surrounding geography. Some functions can be carried out in partnership with other government entities, as when a water or parks district works in concert with a county government; or when agencies at the regional level work directly under the mandate of a state or provincial government.
Ten Years of TRAIL
Authors: Nesdill Daureen , Sare Laura , Trussell Alice , Von Seggern Marilyn
Published: December 2016

The year 2016 marks the tenth year the members of the Technical Report Archive and Image Library (TRAIL) have been providing open access to US federal technical reports (figure 1). Because TRAIL has created a substantive open access resource over the last ten years,it seems appropriate to look back and reflect on the work of TRAIL.
Science, Agriculture, and Nutrition: The Government Documents that Influenced a Nation’s Food and Diet
Authors: Henriques Charmaine
Published: December 2016

Since its creation in 1862, the United States Department of Agriculture (USDA) has published bulletins, reports, pamphlets, posters and a variety of other informational resources. These materials have facilitated the crafting of strategies that have shaped the nutritional standards of the country but also records scientific and technological advances in farming, agriculture and food production. These publications (dating back from the 1800s to the present) help tell the stories of how U.S. federal agricultural policies have advanced the health and welfare of a growing American population.
From the Chair: Working for GODORT in “The City that Works”
Authors: Erekson Sarah
Published: December 2016

It is an exciting time to be part of the American Library Association’s Government Documents Round Table. We are marking some milestone changes this year: moving to an electronically published journal and implementing a GODORT subscription to virtual meeting software. Some of these changes have been a long time in coming—many GODORT groups met virtually via teleconferences and collaboration software hosted through members’ institutions for years. Much of the work of GODORT in the past year has been to reassess our traditions. (I particularly liked the Fiddler on the Roof-themed column from the last “From the Chair”). But one tradition I still want to embrace is to use the first column of “From the Chair” to introduce myself and my vision for the 2016–17 term.
International Docs: The Embattled UN Depository
Authors: Church Jim
Published: December 2016

Last year I wrote a DttP column about the United Nations Depository Library System (UNDL), but much has changed since, unfortunately for the worse. The situation has become so serious and the UN Department of Public Information’s (DPI) handling of the issue so confusing, I have almost lost faith in UN Publishing. While several advocacy efforts are underway, including a letter-writing campaign from UN Depositories around the world, an ALA Resolution,and collaborative efforts with other nongovernmental organizations, the DPI seems chiefly focused on its short-term financial interests rather than access to UN information. The communications released by the DPI have also been fraught with complexity and inconsistencies. If we support open access to information, we need to rebuff decisions made by the DPI and UN Publications to effectively disband the UN Depository Library System. This article is both a challenge and a plea to the UN to alter course and reinstate a robust UN depository program, to embrace open access, and to foster digital redundancy.
Basic Project Management for Weeding Government Documents Collections
Authors: McDonald Celina
Published: December 2016

For as long as academic libraries have participated in the federal depository library program, there has been an inherent conflict between their academic and depository mandates. While state and public libraries are tasked with serving the greater public, academic libraries have an imperative to meet the specific needs of their institutions. As institutional priorities have evolved and new needs emerged, many academic depositories have come to face pressures of staffing and physical space that lead to the desire to downsize their physical government documents holdings in favor of digital surrogates. Because the government documents received through the federal depository library program are not the libraries’ property, withdrawing these materials is a time consuming, labor intensive, costly, and complicated undertaking.
Preservation of Federal Government Publications in Multiple Formats Proposal
Authors: Preservation Working Group GODORT
Published: December 2016

The GODORT Preservation Working Group urges the Government Documents Round Table (GODORT) to promote a national conversation about the value of preserving historic Government publications in multiple formats in order to serve a diverse public and to publicize the need for Government publications librarians to help the public access those publications. GODORT should urge ALA to ask the US Congress to appropriate funds for preservation of Federal Depository Library Program government publications. This money should be used for direct support of depository libraries who want to preserve their paper and digital government publications.
Power and Change in the US Cataloging Community
Authors: Knowlton Steven A.
Published: December 2016

The US cataloging community is an interorganizational network with the Library of Congress (LC) as the lead organization, which reserves to itself the power to shape cataloging rules. Peripheral members of the network who are interested in modifying changes to the rules or to the network can use various strategies for organizational change that incorporate building ties to the decision-makers located at the hub of the network. The story of William E. Studwell’s campaign for a subject heading code illustrates how some traditional scholarly methods of urging change—papers and presentations—are insufficient to achieve reform in an interorganizational network, absent strategies to build alliances with the decision makers.
Autonomous Sensing Architected Materials
Authors: Utzeri Mattia , Cebeci Hülya , Kumar Shanmugam
Published: September 2024

Integrating autonomous sensing materials into future applications necessitates developing advanced multiscale multiphysics predictive models. This study introduces an experimentally informed predictive framework for autonomous sensing architected materials, combining theoretical and computational methodologies. By incorporating stress‐dependent electrical resistivity through anisotropic piezoresistive constitutive effects, alongside considering material, geometric, and contact nonlinearities, the proposed multiscale model captures the architecture‐dependent piezoresistive responses of lattice composites produced via additive manufacturing of polyetherimide (PEI)/carbon nanotube (CNT) nanoengineered feedstock. The PEI/CNT composite exhibits exceptional strength (105 MPa), stiffness (3368 MPa), and strain sensitivity (gauge factor ≈13), translating into remarkable piezoresistive characteristics for the PEI/CNT lattice composites, surpassing existing works (gauge factor ≈3 to 11). This multiscale finite element model accurately predicts both macroscopic piezoresistive responses and the influence of architectural and topological variations on electric current paths, validated via infrared thermography analysis. Additionally, an Ashby chart for the gauge factor of PEI/CNT lattice composites suggests their prediction through a scaling law similar to mechanical properties, underscoring the tunable strain and damage sensitivity of these materials. The combined experimental, theoretical, and numerical findings offer critical insights into optimizing piezoresistive composites through architected design, with profound implications for smart orthopedics, structural health monitoring, sensors, batteries, and other multifunctional applications.
Cognitive, Social, and Emotional‐Behavioral Outcomes in Children and Adolescents With Beckwith–Wiedemann Syndrome
Authors: Butti Niccolò , Urgesi Cosimo , Mussa Alessandro , Montirosso Rosario
Published: September 2024

Although Beckwith–Wiedemann syndrome spectrum (BWSp) is not usually associated with intellectual disability, recent evidences calls for further investigation of cognitive development and academic skills in children with BWSp. Moreover, research has documented social difficulties and emotional‐behavioral problems associated with BWSp. Nevertheless, a full characterization of socio‐emotional development in BWSp is still lacking. In the current study, cognitive and socio‐emotional development was assessed in 29 children with BWSp aged 5–18 years, using a test of nonverbal intelligence, a neuropsychological battery covering multiple domains, academic skills tests, and questionnaires evaluating autistic traits and emotional‐behavioral problems. As expected, most participants showed adequate performance in cognitive tests. However, the findings also highlighted greater difficulties in language than visuospatial processing, strengths in social perception, as well as slowness in reading and mental calculation. The assessment of emotional‐behavioral difficulties indicated a prevalent phenotype characterized by increased anxiety, low self‐esteem, social withdrawal and a tendency to control externalizing reactions, but no associations with autistic traits, cognitive outcomes, and the clinical score proposed by the recent Consensus statement. Increased social perception and internalization problems likely result from coping strategies with social and care‐related stress. Overall, the findings of this study inform clinical management and genetic counseling for children and adolescents with BWSp.
Identification of dilated cardiomyopathy‐linked key genes by bioinformatics methods and evaluating the impact of tannic acid and monosodium glutamate in rats
Authors: Karadas Habibe , Tosun Hilal , Ceylan Hamid
Published: September 2024

Dilated cardiomyopathy (DCM) is the most common type of myocardial dysfunction, affecting mostly young adults, but its therapeutic diagnosis and biomarkers for prognosis are lacking. This study aimed to investigate the possible effect of the common food additive monosodium glutamate (MSG) and tannic acid (TA), a phenolic compound, on the key molecular actors responsible for DCM. DCM‐related publicly available microarray datasets (GSE120895, GSE17800, and GSE19303) were downloaded from the comprehensive Gene Expression Omnibus (GEO) database, and analyzed to identify differentially expressed genes (DEGs). By integrating DEGs and gene‐disease validity curation results, overlapping genes were screened and identified as hub genes. Protein‐protein interaction (PPI) network and ontology analysis were performed to make sense of the identified biological data. Finally, mRNA expression changes of identified hub genes in the heart tissues of rats treated with MSG and TA were measured by the qPCR method. Six upregulated (IGF1, TTN, ACTB, LMNA, EDN1, and NPPB) DEGs were identified between the DCM and healthy control samples as the hub genes. qPCR results revealed that the mRNA levels of these genes involved in DCM development increased significantly in rat heart tissues exposed to MSG. In contrast, this increase was remarkably alleviated by TA treatment. Our results provide new insights into critical molecular mechanisms that should be focused on in future DCM studies. Moreover, MSG may play a critical role in DCM formation, and TA may be used as a promising therapeutic agent in DCM.
Elucidating the protective mechanism of ganoderic acid DM on breast cancer based on network pharmacology and in vitro experimental validation
Authors: Swallah Mohammed Sharif , Bondzie‐Quaye Precious , Yu Xin , Fetisoa Monia Ravelonandrasana , Shao Chang‐Sheng , Huang Qing
Published: September 2024

Ganoderma lucidum, a popular medicinal fungus, has been utilized to treat a variety of diseases. It possesses a unique therapeutic and pharmacological reputation in suppressing cancer/tumor progression, especially breast cancer, due to its embedded rich bioactive chemical constituents, mainly triterpenoids (ganoderic acids). The most prevalent malignant tumor in women with a high mortality and morbidity rate is breast cancer. Ganoderic acids A, D, DM, F, and H are evidenced in previous research to have breast cancer–preventive properties by exhibiting autophagic and apoptosis, anti‐proliferative, and anti‐angiogenesis effects. However, the anti‐breast cancer mechanism remains unclear. The putative targets of the ganoderic acids were further determined using bioinformatics techniques and molecular docking calculation. Finally, the key targets were verified in vitro. A total of 53 potential target proteins associated with 202 pathways were predicted to be related to breast cancer. The potential targets were narrowed down to six key targets (AKT1, PIK3CA, epidermal growth factor receptor [EGFR], STAT1, ESR1, and CTNNB1), using different algorithms of the CytoHubba plugin, which were further validated using molecular docking analysis. The ganoderic acid DM (GADM) and the targets (PIK3CA and EGFR) with the strongest interactions were validated via MDA‐MB‐231 and MCF7 cells. The expression level of PIK3CA in both MDA‐MB‐231 and MCF7 cells was dose‐dependently suppressed by GADM, whereas EGFR expression was unexpectedly increased, which warrants further investigation. These data indicated that the network pharmacology–based prediction of GADM targets for treating human breast cancer could be reliable.
Annexin A1 protects periodontal ligament cells against lipopolysaccharide‐induced inflammatory response and cellular senescence: An implication in periodontitis
Authors: Luo Shuwen , Zhang Lin , Li Xiaoyu , Tong Chunshi
Published: September 2024

Periodontitis is an inflammatory condition that affects the tooth‐supporting structures, triggered by the host's immune response toward the bacterial deposits around the teeth. Annexin A1 (AnxA1), a vital member of the annexin superfamily, is known for its diverse physiological functions, particularly its anti‐inflammatory and anti‐senescence properties. We hypothesized that AnxA1 has a protective effect against lipopolysaccharide (LPS)‐induced inflammatory responses and cellular damage in periodontal ligament cells (PDLCs). In this study, we demonstrate that LPS stimulation significantly reduced telomerase activity in PDLCs, a decline that was dose‐dependently reversed by AnxA1. Importantly, AnxA1 protected the cells from LPS‐induced cellular senescence and the downregulation of human telomerase reverse transcriptase (hTERT) expression. In line with this, AnxA1 suppressed the LPS‐induced expression of p21 and p16 at both the mRNA and protein levels. Furthermore, AnxA1 demonstrated potent anti‐inflammatory effects by inhibiting the secretion of interleukin 6 (IL‐6), interleukin 8 (IL‐8), and monocyte chemoattractant protein‐1 (MCP‐1). It also mitigated LPS‐induced oxidative stress by reducing the levels of phosphorylated Foxo3a (Ser253) and restored sirtuin 1 (SIRT1) expression. Notably, SIRT1 silencing abolished AnxA1's protective effects on Foxo3a phosphorylation and cellular senescence, suggesting that SIRT1 mediates AnxA1's actions. In conclusion, AnxA1 protected PDLCs against LPS‐triggered inflammation and cell senescence by activating SIRT1 signal pathway. These findings indicate that AnxA1 could serve as a promising therapeutic strategy for the treatment of periodontitis.
Risk factors investigation for different outcomes between unilateral and bilateral chronic rhinosinusitis with nasal polyps patients
Authors: Wang Jianwei , Zhang Yu , Chen Ying , Xu Xinjun , Yang Yujuan , Yin Jiali , Guo Jing , Yu Pengyi , Liu Zhen , Liu Huifang , Zuo Ting , Zhao Hongfei , Hao Yan , Zhang Bei , Song Xicheng
Published: September 2024

Background

Studies involving chronic rhinosinusitis with nasal polyps (CRSwNP) have mostly focused on bilateral cases, making unilateral CRSwNP inadequately recognized. This study examined the differences in clinical characteristics, outcomes, and risk factors for poor outcomes between unilateral and bilateral CRSwNP to facilitate a better assessment in the two groups.

Methods

Demographic information, tissue and blood cells, endoscopic scores, Lund‐Mackay scores, recurrence rates, and disease control conditions were compared between 310 unilateral and 596 bilateral CRSwNP patients. Furthermore, the stepwise regression multivariate Cox proportional hazard models were performed to generate risk factors for poor outcomes in the two groups.

Results

Bilateral cases exhibited higher rates of smoking, AR, and asthma comorbidities, along with higher numbers of tissue eosinophils and blood inflammatory cells when compared to unilateral patients. Endoscopic nasal polyp score, total computed tomography (CT) score (with scores for each sinus cavity), and adjusted CT scores were significantly higher in the bilateral group, except for a markedly higher adjusted maxillary score in the unilateral group. Furthermore, significantly higher proportions of bilateral patients experienced nasal polyp recurrence, uncontrolled status, and most disease control‐related symptoms at follow‐up. The primary risk factors for poor outcomes were asthma, tissue eosinophils, and total CT score in the bilateral group and blood basophils in the unilateral group.

Conclusions

Bilateral CRSwNP patients experience worse disease severity and outcomes than their unilateral counterparts. Primarily, asthma, tissue eosinophils, and total CT score were risk factors for poor outcomes in bilateral CRSwNP patients, with blood basophils in unilateral cases.
Tristetraprolin affects invasion‐associated genes expression and cell motility in triple‐negative breast cancer model
Authors: Hubiernatorova Anastasiia , Novak Josef , Vaskovicova Michaela , Sekac David , Kropyvko Serhii , Hodny Zdenek
Published: September 2024

Tristetraprolin (TTP) is an RNA‐binding protein that negatively regulates its target mRNAs and has been shown to inhibit tumor progression and invasion. Tumor invasion requires precise regulation of cytoskeletal components, and dysregulation of cytoskeleton‐associated genes can significantly alter cell motility and invasive capability. Several genes, including SH3PXD2A, SH3PXD2B, CTTN, WIPF1, and WASL, are crucial components of the cytoskeleton reorganization machinery and are essential for adequate cell motility. These genes are also involved in invasion processes, with SH3PXD2A, SH3PXD2B, WIPF1, and CTTN being key components of invadopodia—specialized structures that facilitate invasion. However, the regulation of these genes is not well understood. This study demonstrates that ectopic expression of TTP in MDA‐MB‐231 cells leads to decreased mRNA levels of CTTN and SH3PXD2A, as well as defects in cell motility and actin filament organization. Additionally, doxorubicin significantly increases TTP expression and reduces the mRNA levels of cytoskeleton‐associated genes, enhancing our understanding of how doxorubicin may affect the transcriptional profile of cells. However, doxorubicin affects target mRNAs differently than TTP ectopic expression, suggesting it may not be the primary mechanism of doxorubicin in breast cancer (BC) treatment. High TTP expression is considered as a positive prognostic marker in multiple cancers, including BC. Given that doxorubicin is a commonly used drug for treating triple‐negative BC, using TTP as a prognostic marker in this cohort of patients might be limited since it might be challenging to understand if high TTP expression occurred due to the favorable physiological state of the patient or as a consequence of treatment.
Expression analysis of genes including Zfhx4 in mice and zebrafish reveals a temporospatial conserved molecular basis underlying craniofacial development
Authors: Liu Shujie , Xu Lin , Kashima Makoto , Narumi Rika , Takahata Yoshifumi , Nakamura Eriko , Shibuya Hirotoshi , Tamura Masaru , Shida Yuki , Inubushi Toshihiro , Nukada Yuko , Miyazawa Masaaki , Hata Kenji , Nishimura Riko , Yamashiro Takashi , Tasaki Junichi , Kurosaka Hiroshi
Published: September 2024

Background

Embryonic craniofacial development involves several cellular and molecular events that are evolutionarily conserved among vertebrates. Vertebrate models such as mice and zebrafish have been used to investigate the molecular and cellular etiologies underlying human craniofacial disorders, including orofacial clefts. However, the molecular mechanisms underlying embryonic development in these two species are unknown. Therefore, elucidating the shared mechanisms of craniofacial development between disease models is crucial to understanding the underlying mechanisms of phenotypes in individual species.

Results

We selected mice and zebrafish as model organisms to compare various events during embryonic craniofacial development. We identified genes (Sox9, Zfhx3 and 4, Cjun, and Six1) exhibiting similar temporal expression patterns between these species through comprehensive and stage‐matched gene expression analyses. Expression analysis revealed similar gene expression in hypothetically corresponding tissues, such as the mice palate and zebrafish ethmoid plate. Furthermore, loss‐of‐function analysis of Zfhx4/zfhx4, a causative gene of human craniofacial anomalies including orofacial cleft, in both species resulted in deformed skeletal elements such as the palatine and ethmoid plate in mice and zebrafish, respectively.

Conclusions

These results demonstrate that these disease models share common molecular mechanisms, highlighting their usefulness in modeling craniofacial defects in humans.
Carbon Nitride‐Supported Zinc Oxide Nanocomposite for the Electrochemical Detection of Dopamine and the Development of Disposable Sensors
Authors: Saha Chandan , Ghosh Sarit K , Kumari Pooja , Perla Venkata K , Singh Harishchandra , Mallick Kaushik
Published: September 2024

The carbon nitride‐supported zinc oxide (CNZO) nanocomposite was synthesized through a high‐temperature synthesis method, resulting in zinc oxide nanoparticles with an average size of ~44 nm, dispersed on a carbon nitride matrix. X‐ray diffraction confirmed the formation of the hexagonal wurtzite phase of zinc oxide, with a space group of P63mc. X‐ray photoelectron spectroscopy and Fourier‐transform infrared analysis further verified the presence of both zinc oxide and carbon nitride. The CNZO nanocomposite served as a catalyst for the electrochemical detection of dopamine, achieving limit of detection and sensitivity of 2.66 μM and 6.23 μA μM−1 cm−2 respectively, using square wave voltammetry technique. Cyclic voltammetry experiments demonstrated excellent electroactivity of the CNZO nanocomposite in a neutral pH environment. An electrochemical paper‐based analytical device (EPAD) was designed and successfully employed for the electrochemical analysis of dopamine in pharmaceutical samples using CNZO nanocomposites. Additionally, CNZO was used as an active material in the development of a disposable dopamine sensor based on an extended gate field‐effect transistor (EG‐FET). This sensor exhibited a sensitivity and limit of detection 18.22 μA μM−1 cm−2 and 0.36 μM, respectively, with a correlation coefficient of 0.99.