Effect of a Co-Located Bridging Recovery Initiative on Hospital Length of Stay Among Patients With Opioid Use Disorder
Authors: Marcovitz David , Dear Mary Lynn , Donald Rebecca , Edwards David A. , Kast Kristopher A. , Le Thao D. V. , Shah Mauli V. , Ferrell Jason , Gatto Cheryl , Hennessy Cassandra , Buie Reagan , Rice Todd W. , Sullivan William , White Katie D. , Van Winkle Grace , Wolf Rachel , Lindsell Christopher J. ,   Vanderbilt Learning Healthcare System Platform Investigators, Bernard Gordon R. , Dittus Robert S. , Dwyer Shon , Embi Peter J. , Fitzgerald Chad , Freundlich Robert E. , Harrell Frank E. , Harris Paul A. , Hartert Tina , Hayman Jim , Ivory Catherine H. , Kleinpell Ruth , Kripalani Sunil , Liska Lee Ann , Luther Patrick , Morrison Jay , Nantais Thomas , Pulley Jill M. , Rehm Kris , Rothman Russell L. , Runyan Patti , Self Wesley H. , Semler Matthew W. , Steaban Robin , Stone Cosby A. , Walker Philip D. , Wilkins Consuelo H. , Wright Adam , Zuckerman Autumn D. 
Published: February 2024

Importance

Co-located bridge clinics aim to facilitate a timely transition to outpatient care for inpatients with opioid use disorder (OUD); however, their effect on hospital length of stay (LOS) and postdischarge outcomes remains unclear.

Objective

To evaluate the effect of a co-located bridge clinic on hospital LOS among inpatients with OUD.

Design, Setting, and Participants

This parallel-group randomized clinical trial recruited 335 adult inpatients with OUD seen by an addiction consultation service and without an existing outpatient clinician to provide medication for OUD (MOUD) between November 25, 2019, and September 28, 2021, at a tertiary care hospital affiliated with a large academic medical center and its bridge clinic.

Intervention

The bridge clinic included enhanced case management before and after hospital discharge, MOUD prescription, and referral to a co-located bridge clinic. Usual care included MOUD prescription and referrals to community health care professionals who provided MOUD.

Main Outcomes and Measures

The primary outcome was the index admission LOS. Secondary outcomes, assessed at 16 weeks, were linkage to health care professionals who provided MOUD, MOUD refills, same-center emergency department (ED) and hospital use, recurrent opioid use, quality of life (measured by the Schwartz Outcome Scale–10), overdose, mortality, and cost. Analysis was performed on an intent-to-treat basis.

Results

Of 335 participants recruited (167 randomized to the bridge clinic and 168 to usual care), the median age was 38.0 years (IQR, 31.9-45.7 years), and 194 (57.9%) were male. The median LOS did not differ between arms (adjusted odds ratio [AOR], 0.94 [95% CI, 0.65-1.37]; P = .74). At the 16-week follow-up, participants referred to the bridge clinic had fewer hospital-free days (AOR, 0.54 [95% CI, 0.32-0.92]), more readmissions (AOR, 2.17 [95% CI, 1.25-3.76]), and higher care costs (AOR, 2.25 [95% CI, 1.51-3.35]), with no differences in ED visits (AOR, 1.15 [95% CI, 0.68-1.94]) or deaths (AOR, 0.48 [95% CI, 0.08-2.72]) compared with those receiving usual care. Follow-up calls were completed for 88 participants (26.3%). Participants referred to the bridge clinic were more likely to receive linkage to health care professionals who provided MOUD (AOR, 2.37 [95% CI, 1.32-4.26]) and have more MOUD refills (AOR, 6.17 [95% CI, 3.69-10.30]) and less likely to experience an overdose (AOR, 0.11 [95% CI, 0.03-0.41]).

Conclusions and Relevance

This randomized clinical trial found that among inpatients with OUD, bridge clinic referrals did not improve hospital LOS. Referrals may improve outpatient metrics but with higher resource use and expenditure. Bending the cost curve may require broader community and regional partnerships.

Trial Registration

ClinicalTrials.gov Identifier: NCT04084392