bluuebunny/crossref_metadata_2025 huggingface dataset:
Atlas of the anatomical localization of atypical chemokine receptors in healthy mice
Authors: Melgrati Serena , Radice Egle , Ameti Rafet , Hub Elin , Thelen Sylvia , Pelczar Pawel , Jarrossay David , Rot Antal , Thelen Marcus
Published: May 2023

Atypical chemokine receptors (ACKRs) scavenge chemokines and can contribute to gradient formation by binding, internalizing, and delivering chemokines for lysosomal degradation. ACKRs do not couple to G-proteins and fail to induce typical signaling induced by chemokine receptors. ACKR3, which binds and scavenges CXCL12 and CXCL11, is known to be expressed in vascular endothelium, where it has immediate access to circulating chemokines. ACKR4, which binds and scavenges CCL19, CCL20, CCL21, CCL22, and CCL25, has also been detected in lymphatic and blood vessels of secondary lymphoid organs, where it clears chemokines to facilitate cell migration. Recently, GPR182, a novel ACKR-like scavenger receptor, has been identified and partially deorphanized. Multiple studies point towards the potential coexpression of these 3 ACKRs, which all interact with homeostatic chemokines, in defined cellular microenvironments of several organs. However, an extensive map of ACKR3, ACKR4, and GPR182 expression in mice has been missing. In order to reliably detect ACKR expression and coexpression, in the absence of specific anti-ACKR antibodies, we generated fluorescent reporter mice, ACKR3GFP/+, ACKR4GFP/+, GPR182mCherry/+, and engineered fluorescently labeled ACKR-selective chimeric chemokines for in vivo uptake. Our study on young healthy mice revealed unique and common expression patterns of ACKRs in primary and secondary lymphoid organs, small intestine, colon, liver, and kidney. Furthermore, using chimeric chemokines, we were able to detect distinct zonal expression and activity of ACKR4 and GPR182 in the liver, which suggests their cooperative relationship. This study provides a broad comparative view and a solid stepping stone for future functional explorations of ACKRs based on the microanatomical localization and distinct and cooperative roles of these powerful chemokine scavengers.
Maladaptation as a concept and a metric in national adaptation policy- Should we, would we, could we?
Authors: Juhola Sirkku , Käyhkö Janina
Published: May 2023

Implementation of national adaptation policy is advancing. There also appears to be a shift, albeit slow, from monitoring of implementation to evaluation of outcomes of the policy. However, there is an absence of an agreed definition or metrics to indicate when national level implementation fails or goes wrong. The concept of maladaptation remains elusively defined in the adaptation policy sphere but is often evoked in national adaptation plans. Empirical research on maladaptation related to national adaptation policies is lacking, despite claims of it increasingly taking place. This review discusses whether maladaptation should be operationalised as a concept in national adaptation policy, how it would be done and what could it take to make it happen. The paper argues that unless failure of adaptation policy is considered, understanding the adaptation gap, for example, becomes even more challenging.
Evaluation of the effect of a midwife-led online program using cognitive behavioral therapy for pregnant women at risk for anxiety disorder in Japan: A pilot randomized controlled trial
Authors: Okatsu Aiko , Kanie Ayako , Kataoka Yaeko
Published: May 2023

Aim

This study aimed to conduct a pilot randomized controlled trial (RCT) to examine the appropriateness and feasibility of a midwife-led cognitive behavioral therapy (CBT)-based, three-session program delivered remotely to pregnant women at risk for anxiety disorders.

Methods

The study design was a pilot RCT. Outcome was the difference between the two groups in the change in generalized anxiety disorder-7 (GAD-7), Kessler6 (K6) and Edinberg Postnatal Depression Scale (EPDS) etc. Recruitment was conducted from August 2020 to July 2021 in clinics and web-based survey monitors in Japan, with follow-up through November 2021.

Results

This program involving 63 pregnant women were administered. Although the intervention was remote, a total of three sessions was completed during pregnancy. The change in GAD-7 scores from pre- to 1 month postpartum, was mean -1.77 in the intervention group and mean -0.97 in the control group, with a p-value of .521, indicating no significant difference between the two groups, although GAD-7 scores were lower in the intervention group. The change in K6 score from pre- to 1 month postpartum, was mean -3.55 in the intervention group and mean -1.62 in the control group, with a p-value of .168, indicating no significant difference between the two groups, although the intervention group showed a greater decrease. In particular, in primiparas, the change in GAD-7 scores in the intervention group was large, and some expressed a desire for a postpartum session, suggesting that a follow-up session after delivery may be effective. In multiparas, the control group showed an increase in both GAD-7 and K6 scores from late pregnancy to 1 month postpartum, while the intervention group showed a decrease in scores.

Conclusion

The program was implemented using CBT conducted by midwife, anxiety decreased in primiparas. In future RCTs, it was suggested that additional postpartum sessions may be effective.

Trial registration

UMIN Clinical trial registry ID: UMIN000040304.
Adaptive sport as affirmation: “We focus on our strengths, not our disabilities”
Authors: Schwartz Norah Anita , von Glascoe Christine Alysse
Published: May 2023

This paper offers a counter-narrative to the stereotype of people with physical and cognitive impairments being less inclined to participate in athletic activities. It contributes to the affirmative model proposed by Swain and French, which posits a non-tragic view of disability that encompasses positive social identities. We employed the tools of ethnography and phenomenology to explore the adaptive athlete experience among individuals practicing various sports and exhibiting divergent levels of proficiency. Findings confirm the appropriateness of the affirmative model and provide examples of movement from the state of liminality to that of communitas as defined by Victor Turner.
Development and characterization of chimera of yellow fever virus vaccine strain and Tick-Borne encephalitis virus
Authors: Kuznetsova Nadezhda , Siniavin Andrei , Butenko Alexander , Larichev Victor , Kozlova Alina , Usachev Evgeny , Nikiforova Maria , Usacheva Olga , Shchetinin Alexey , Pochtovyi Andrei , Shidlovskaya Elena , Odintsova Alina , Belyaeva Elizaveta , Voskoboinikov Aleksander , Bessonova Arina , Vasilchenko Lyudmila , Karganova Galina , Zlobin Vladimir , Logunov Denis , Gushchin Vladimir , Gintsburg Alexander
Published: May 2023

Tick-borne encephalitis virus (TBEV) is one of the most threatening pathogens which affects the human central nervous system (CNS). TBEV circulates widely in Northern Eurasia. According to ECDC, the number of TBE cases increase annually. There is no specific treatment for the TBEV infection, thus vaccination is the main preventive measure. Despite the existence of several inactivated vaccines currently being licensed, the development of new TBEV vaccines remains a leading priority in countries endemic to this pathogen. Here we report new recombinant virus made by infectious subgenomic amplicon (ISA) approach using TBEV and yellow fever virus vaccine strain (YF17DD-UN) as a genetic backbone. The recombinant virus is capable of effective replication in mammalian cells and induce TBEV-neutralizing antibodies in mice. Unlike the original vector based on the yellow fever vaccine strain, chimeric virus became neuroinvasive in doses of 107−106 PFU and can be used as a model of flavivirus neuroinvasiveness, neurotropism and neurovirulence. These properties of hybrid structures are the main factors limiting their practical use as vaccines platforms.
Effective encoder-decoder neural network for segmentation of orbital tissue in computed tomography images of Graves’ orbitopathy patients
Authors: Lee Seung Hyeun , Lee Sanghyuck , Lee Jaesung , Lee Jeong Kyu , Moon Nam Ju
Published: May 2023

Purpose

To propose a neural network (NN) that can effectively segment orbital tissue in computed tomography (CT) images of Graves’ orbitopathy (GO) patients.

Methods

We analyzed orbital CT scans from 701 GO patients diagnosed between 2010 and 2019 and devised an effective NN specializing in semantic orbital tissue segmentation in GO patients’ CT images. After four conventional (Attention U-Net, DeepLab V3+, SegNet, and HarDNet-MSEG) and the proposed NN train the various manual orbital tissue segmentations, we calculated the Dice coefficient and Intersection over Union for comparison.

Results

CT images of the eyeball, four rectus muscles, the optic nerve, and the lacrimal gland tissues from all 701 patients were analyzed in this study. In the axial image with the largest eyeball area, the proposed NN achieved the best performance, with Dice coefficients of 98.2% for the eyeball, 94.1% for the optic nerve, 93.0% for the medial rectus muscle, and 91.1% for the lateral rectus muscle. The proposed NN also gave the best performance for the coronal image. Our qualitative analysis demonstrated that the proposed NN outputs provided more sophisticated orbital tissue segmentations for GO patients than the conventional NNs.

Conclusion

We concluded that our proposed NN exhibited an improved CT image segmentation for GO patients over conventional NNs designed for semantic segmentation tasks.
The influence of acculturation on the risk of preterm birth and low birthweight in migrant women residing in Western Australia
Authors: Mozooni Maryam , Pereira Gavin , Preen David Brian , Pennell Craig Edward
Published: May 2023

Background

The risk of preterm birth (PTB) and low birthweight (LBW) may change over time the longer that immigrants reside in their adopted countries. We aimed to study the influence of acculturation on the risk of these outcomes in Australia.

Methods

A retrospective cohort study using linked health data for all non-Indigenous births from 2005–2013 in Western Australia was undertaken. Acculturation was assessed through age on arrival, length of residence, interpreter use and having an Australian-born partner. Adjusted odds ratios (aOR) for term-LBW and PTB (all, spontaneous, medically-indicated) were calculated using multivariable logistic regression in migrants from six ethnicities (white, Asian, Indian, African, Māori, and ‘other’) for different levels of acculturation, compared to the Australian-born population as the reference.

Results

The least acculturated migrant women, those from non-white non-Māori ethnic backgrounds who immigrated at age ≥18 years, had an overseas-born partner, lived in Australia for < 5 years and used a paid interpreter, had 58% (aOR 1.58, 95% CI 1.15–2.18) higher the risk of term-LBW and 40% (aOR 0.60, 95% CI 0.45–0.80) lower risk of spontaneous PTB compared to the Australian-born women. The most acculturated migrant women, those from non-white non-Māori ethnic backgrounds who immigrated at age <18 years, had an Australian-born partner, lived in Australia for > 10 years and did not use an interpreter, had similar risk of term-LBW but 43% (aOR 1.43, 95% CI 1.14–1.78) higher risk of spontaneous PTB than the Australian-born women.

Conclusion

Acculturation is an important factor to consider when providing antenatal care to prevent PTB and LBW in migrants. Acculturation may reduce the risk of term-LBW but, conversely, may increase the risk of spontaneous PTB in migrant women residing in Western Australia. However, the effect may vary by ethnicity and warrants further investigation to fully understand the processes involved.
Effect of Tai Chi on stress, anxiety, and self-perception of happiness: a longitudinal intervention study
Authors: Cezário Laís Renata Almeida , Ambrosano Gláucia Maria Bovi , Ambrosano Guilherme Bovi , Taíra Anderson , Possobon Rosana de Fátima , Meneghim Marcelo de Castro , Cortellazzi Karine Laura
Published: May 2023

This intervention follow-up study evaluated anxiety and stress levels and self-perceived happiness of individuals linked to the health field who did not practice Tai Chi and compared these variables before and after practicing this art. One hundred twenty-three participants were subdivided into two groups: G1) Older health professionals (n=41) and G2) Younger pre-university students interested in the health field (n=82). Participants received a 60-minute Tai Chi class. The Perceived Stress Scale (PSS-14) was applied before the practice, and the State-Trait Anxiety Inventory (STAI) and Andrews Face Scale were used before and after the class. Generalized linear models and the Bowker symmetry test were applied for data analysis. 46.3% and 30.5% of participants in G1 and G2 had mild stress levels, and 43.9% and 46.3% had moderate stress levels, respectively. After practicing Tai Chi, both groups presented significantly lower mean anxiety scores. In G1, 31.7% of participants went from moderate to mild anxiety levels after practice, 19.5% from severe to moderate, and 7.3% from severe to mild. In G2, 28.2% of participants went from moderate to mild anxiety levels after practice, 18.3% from severe to moderate, and 6.1% from severe to mild. Furthermore, 100.0% of individuals in G1 and 96.3% in G2 were happy after the class. Tai Chi was effective in reducing anxiety levels and improving self-perceived happiness.
The Influence of CAR, FDR, Inflation, GDP, Mudharabah Financing, and Musyarakah Financing on NPF of Islamic Commercial Banks in Indonesia
Authors: Iswanto Bambang
Published: May 2023

Islamic finance in Indonesia has shown significant development. The development of sharia finance will increase the growth of sharia banks that operate and will have a positive impact on Islamic banks. However, with the development of Islamic banks, risky financing cannot be avoided, because the strategic function of banks is to distribute funds to the public for the sustainability of the country's economy and the welfare of the community. This study aims to determine the effect of CAR, FDR, Inflation, GDP, Mudharabah Financing, and Musyarakah Financing on the financing risk of Islamic Commercial Banks in Indonesia for the Period of 2015-2021. In contrast to previous research studies, this study added a zakat instrument to the GDP variable. This research is quantitative research using multiple linear regression. The population is 14 Islamic commercial banks. The sampling technique used is a purposive sampling technique so a sample of 8 Islamic commercial banks was obtained. The results of this study show that CAR, FDR, and Inflation have a significant negative effect on NPF, GDP, and Mudharabah Financing has a significant positive effect to NPF, Musyarakah Financing has an insignificant negative effect on NPF.
Dispelling the Ambivalence of Salt Farmer Welfare Policy: Study of Grassroots Ethnography in Local Wisdom Innovation in Mangunlegi Village
Authors: Aulia Hana , Asyraf Muhammad Affan , Febriani Untari , Iffah Rona , Kastiureni Seren
Published: May 2023

Economic problems and the complexity of salt production have riddled government policies to alleviate salt farmers’poverty. This raises the question of how to optimise policies that can impact the welfare of salt farmers. Basedon this problematization, this paper attempts to explore the ambivalence of government intervention in the PUGAR(People’s Salt Business Empowerment) policy to alleviate poverty for salt farmers in Mangunlegi Village, BatanganDistrict, Pati. Using an ethnographic approach, the search for policy studies that link the community and the government has illustrated the complexity of the economic growth of salt farmers in Mangunlegi. This complexity is shown by the declining income growth of salt farmers amid the presence of a survival strategy in articulating the meaning of local wisdom and the social environment when people adapt to government policies. The results of this study rest on the possibility of achieving the welfare of Mangunlegi salt farmers through their adaptability to government policies, which lead to grassroots social innovation. For this reason, this study pays attention to the implications of the research results, which reveal that the welfare of salt farmers can be realised if the policies issued by the government do not cause ambivalence. However, if salt farmers are given the freedom to formulate grassroots-based policies, social innovation can be realised. This is one of the solutions to poverty alleviation for salt farmers in Mangunlegi.
Host-Community Readiness Towards Tourism Reactivity: Young People's Perspectives in Greater Bandung
Authors: Rosadi Asep , Susanto Eko , Fitriani Tiara , Dewi Aprilia Nurmala , Cantika Wa Ode Ananda Yayang , Puluhulawa Rosemery Pauline Rumayar
Published: May 2023

Tourism during the pandemic became an actual study topic, the majority of which were studied in terms of changes in tourist behaviour. Plethora studies changes in tourist behaviour selfishly view tourism for the benefit of tourists alone. In contrast, this study examines the readiness factors of community hosts in receiving visits and plays a role in the tourism value chain during the pandemic. Using 310 young respondents living in Indonesia's urban tourism destinations (Greater Bandung), the study confirmed the perceptual factors forming host community readiness. Using SEM-PLS, the study has found that perceptions of internal conditions by the community have a significant impact on the perception of tourism reactivation and the readiness of community hosts. The research model has been able to moderately predict the readiness of community hosts in tourism during the pandemic. Several recommendations were submitted in this study for tourism stakeholders to prepare community hosts in their efforts to achieve successful tourism reactivation.
Understanding the Practices of Strategic CSR in Controversial Industry: Case of Tobacco Company in Indonesia
Authors: Yasmine Shafira Mourina , Swara Vandy Yoga
Published: May 2023

How do tobacco companies take responsibility for social issues under the business existence on health problems and economic issues. The research focuses on a small amount of research in corporate social responsibility (CSR) duty under Tobacco Company. Through the Sampoerna Retail Community (SRC), PT HM Sampoerna Tbk shows a different takes problem-solving of CSR on controversial issues. Through qualitative research, the data, primary data (interviews and observations) and secondary data (documentation studies), coded and analyzed using keywords derived from theory. This study found that CSR in cigarette companies is a form of controversial industrial business strategy that departs from considering business processes' internal and external conditions. The results show SRC is a way for companies to be socially responsible by articulating external conditions (outside-in) dominated by public restrictions on tobacco products and as an internal strategy (inside-out) that departs from the logic of business sustainability. SRC is a form of company compliance with several state regulations, restricting cigarette products and preventing children's access to cigarettes as an outside-in strategy. In the inside-out context, SRC is the company's strategy to ensure all consumers can reach products, collaborating with Fast Moving Consumer Goods (FMCG) companies as an alternative to the uncertainty of controversial industry conditions, and reducing CSR costs.
Minimizing Violence: A Good Practice Local Elite-Based in the Madura Island, Indonesia
Authors: Daulay Pardamean , Raditya Ardhie , Afni Khafsoh Nur
Published: May 2023

The success of democracy in a nation is measured by the existence of a peaceful, civilised social life. In Indonesia, however, ornaments of violence are still present while resolving issues, as in Madura. This study tries to outline the underlying factors that lead to the formation of violence and pinpoint the function that local elites play in curbing the use of violence. The Galtung theory of violence is utilised in the investigational analysis. In order to analyse the data for this study, we used qualitative research, a case study procedure, and an integration strategy. The findings demonstrated that violence has permeated the Madurese culture. Internally passed down and socially sanctioned, it has been used to cope with a variety of life concerns, such as issues involving wives or women, misunderstandings, inheritance, land, religion or belief, theft, and debts and receivables. Because they have historically served as a point of reference in times of conflict, local elites such as Bhuppa/Bhâbu, Ghuru, Rato (parents, Kiai or the leader in the Islamic religion/teacher, and government) are crucial to the realisation of a culture of non-violence. The local elite’s necessary development of their function does not restrict but rather dampens and empowers, notably among the Bâjing.
Participation of Millennials in the Development of the Al-Qur'an Village: A Sustainable Promotion Perspective
Authors: Dianto Icol
Published: May 2023

This study aims to shed light on the government's approach to promoting community involvement in the creation of religious villages. The focus of the study is on community involvement, local government involvement, and policy solutions to ensure the success of Kampung Al-Quran, a religious village development programme in Lumban Dolok Village, Siabu District, Mandailing Natal District. Through the use of qualitative research, observations were concentrated on three distinct locations that served as the hubs of religious activity, interviews with six selected participants who held important positions and knowledge, and documentation data were collected. Including this study, the community actively participated in the construction of the Raya al-Muttaqin mosque, which serves as the central focus of the Kampung Al-Qur'an programme. The village government is still rigorous in how it exercises its authority at the local level, despite the fact that the government lacks an operational strategy for the sustainability of the Kampung Al-Quran programme. It is implied that the Kampung Al-Qur'an programme being carried out in an incalculable way. In order to strengthen the Kampung Al-Qur'an programme in an integrated and long-lasting way, a collaborative strategy is suggested in this article.
Ztracené bohémství v Bohémii.
Authors: Slavková Markéta
Published: May 2023

This study presents the innovative results of repeated ethnographic research and brings insight into the contemporary phenomena of lifestyle migration and backpacking. The studied issue is examined on the example of several groups of foreigners in Český Krumlov, Czechia in the period between approximately 1995 and 2015. These groups were located around several hostels. The main focus is placed on the life trajectories and lifestyle preferences of the studied groups, which are illustrated on the stories of particular actors. In conclusion, the transnational backpackers and lifestyle migrants in Krumlov, i.e., on the alleged “new left bank”, were searching for happier and more content lives. Lifestyle migration was perceived as a certain escape from modernity, consumerism, and materialism. In the first decade of the 21st century, the lifestyle of many of the transnational backpackers could be compared to Bauman’s “vagabond”, nevertheless, presently, the town is “flooded” with tourists. These shifts in the tourism industry according to the majority of the transnational backpackers and lifestyle migrants had a negative impact on the town’s “magic”, which has begun to disappear due to its gentrification and disneylandization.
Says who? Language regard towards speaker groups using English loanwords in Dutch
Authors: Schuring Melissa , Rosseel Laura , Zenner Eline
Published: May 2023

This paper contributes to the ongoing Cognitive Linguistic turn in research on lexical borrowing: rather than searching for objective and universal linguistic criteria to demarcate different contact phenomena, we prioritize language users’ subjective perception of contact-induced change. In particular, combining insights from folk linguistics and social role theory, this paper presents the results from a survey targeting 177 Belgian Dutch respondents’ expectations on the use of English loanwords. The survey uncovers variation in these expectations, depending on the age of the projected speaker (RQ1), on the social role of the projected speaker (RQ2), and whether (unexpected) use of English by projected social role actors leads to negative evaluations (RQ3). Results reveal shared expectations regarding the use of English loans by age, with a perceived peak in late adolescence. Regarding the use of English by social role actors, we find high anticipated use of English loans for modern roles (e.g. rapper, gamer), whilst the expectation on English use for public (e.g. primary school teacher) and traditional roles (e.g. farmer) is significantly lower. Finally, our results indicate that role violation only seems to trigger negative evaluations when the role actor is a public figure with social responsibility. The discussion reflects on the implications of the results, contrasting the top-down or bottom-up emergence of shared beliefs on speaker groups and contact-induced variation.
Mechanism of hypoxia-induced exosome circ_0051799 regulating the progression of lung adenocarcinoma
Authors: Zhu Shunping , Liao Bihong
Published: May 2023

This study attempted to investigate the effect of circ_0051799 on the immune microenvironment of lung adenocarcinoma (LUAD) and the relationship between circ_0051799 and exosomes. The number and morphology of exosomes were verified by nanoparticle tracking, transmission electron microscopy and western blotting. CCK8, EdU, Transwell and flow cytometry were used to verify the regulatory role of exosomes and circ_0051799 on tumor progression. Dual luciferase reporting and RNA immunoprecipitation were used to verify the targeted regulatory relationship between circ_0051799, miR-214-3p and IGF2BP3. WB was used to verify the role of the JAK/STAT pathway in circ_0051799 regulation. Ectopic tumor grafts and in situ models were used to validate in vivo their role in regulating LUAD progression. Hypoxic environment could alter but does not alter its shape. Exosomes can participate in the regulation of macrophage polarization by circ_0051799. In vitro and in vivo assays had shown that circ_0051799 could affect the proliferation and metastasis of LUAD through targeting miR-214-3p mediated IGF2BP3 regulated JAK/STAT pathway. This study found that hypoxia can affect LUAD process by promoting the regulation of macrophage polarization by exosome circ_0051799.
Changes in the long-term stability of GPS, GLONASS and Galileo clocks based on the IGS repro3 campaign
Authors: Maciuk Kamil , Kozioł Krystian , Krzykowska-Piotrowska Karolina , Sisman Yasemin
Published: May 2023

Time is the basis of satellite navigation systems. In precision studies, it is additionally important to ensure accuracy at the highest possible level, up to sub-millimetres. For this purpose, corrections of the clocks of satellites and GNSS reference stations are made available. This type of data is made available in real time in a navigation dispatch with an interval of 10 min–2 h depending on the GNSS system, or in a precision orbit file (interval of 15 min) or in the form of clock correction files (30 s or 300 s). This paper analyses the long-term stability of the clocks of satellites of four GNSS systems. For this purpose, IGS reprocessing data from 1994 to 2020 were used and ADEV (Allan deviation) and three related variances were adopted. The study showed the different nature of the satellite correction for each GNSS system and the increase of the stability over time.
Awareness and interest in osteopathic manipulative treatment in allopathic medical students
Authors: Darby Anne , Parascando Jessica A. , Lipinski Matthew , Lipinski Chang , Mendez-Miller Megan , Berg Arthur , Rabago David , Oser Tamara K.
Published: May 2023

Context

Osteopathic manipulative treatment (OMT) is utilized by clinicians to diagnose and treat a variety of musculoskeletal conditions including acute and chronic pain, and other medical conditions. Previous studies have examined attitudes of allopathic (MD) residents toward OMT and have implemented residency-based curricula; however, literature is lacking on the attitudes of MD students toward OMT.

Objectives

The objective of this study was to determine MD students’ familiarity with OMT and to evaluate their interest in an elective osteopathic curriculum.

Methods

A 15-item online survey was electronically sent to 600 MD students at a large allopathic academic medical center. The survey assessed familiarity with OMT, interest in OMT and in participating in an OMT elective, educational format preference, and interest in pursuing primary care. Educational demographics were also collected. Descriptive statistics and Fisher’s exact test were utilized for categorical variables, and nonparametric tests were utilized for the ordinal and continuous variables.

Results

A total of 313 MD students submitted responses (response rate=52.1 %), of which 296 (49.3 %) responses were complete and utilized for analysis. A total of 92 (31.1 %) students were aware of OMT as a modality in treating musculoskeletal disorders. Among the respondents who indicated “very interested” in learning a new pain treatment modality, the majority: (1) observed OMT in a prior clinical or educational setting (85 [59.9 %], p=0.02); (2) had a friend or family member treated by a DO physician (42 [71.2 %], p=0.01); (3) were pursuing a primary care specialty (43 [60.6 %], p=0.02); or (4) interviewed at an osteopathic medical school (47 [62.7 %], p=0.01). Among those interested in developing some OMT competency, the majority: (1) were pursuing a primary care specialty (36 [51.4 %], p=0.01); (2) applied to osteopathic schools (47 [54.0], p=0.002); or (3) interviewed at an osteopathic medical school (42 [56.8 %], p=0.001). A total of 230 (82.1 %) students were somewhat or very interested in a 2-week elective course in OMT; among all respondents, hands-on labs were the preferred method for delivery of OMT education (272 [94.1 %]).

Conclusions

The study found a strong interest in an OMT elective by MD students. These results will inform OMT curriculum development aimed at interested MD students and residents in order to provide them with OMT-specific theoretical and practical knowledge.
Crystal structure of methyl ((4-aminobenzyl)sulfonyl)-L-prolinate, C13H18N2O4S
Authors: Wang Zhen , Zhao Feng-Lan , Hou Gui-Ge , Meng Qing-Guo
Published: May 2023

C13H18N2O4S, orthorhombic, P212121 (no. 19), a = 6.8619(2) Å, b = 12.0735(4) Å, c = 16.6591(5) Å, V = 1380.16(7) Å3, Z = 4, R

gt
(F) = 0.0236, wR

ref
(F
2) = 0.0604, T = 150 K.
Bufotalin inhibits porcine kidney cortex aminopeptidase N and is cytotoxic to APN+ tumor cells
Authors: Almeida García Fabiola , Rivera Méndez Laura , Frómeta Fuentes Talía , Acén Ravelo Thalía , Alonso Bosch Roberto , Perera Wilmer H. , Arrebola Sánchez Yarini , Bergado Gretchen , Sánchez Ramírez Belinda , Charli Jean-Louis , Pascual Alonso Isel
Published: May 2023

Bufadienolides are steroids that inhibit the Na+/K+ ATPase pump. Recent studies show that members of the bufadienolide family also inhibit the activity of aminopeptidase N (APN). APN is upregulated in different pathologies, including cancer and is a current target for drug development. Bufadienolides are cytotoxic in tumor cells, but there is no enough evidences that inhibition of APN activity contributes to their effect. In the present contribution we investigated the effect of another member of the bufadienolide family, bufotalin, on porcine APN (pAPN) activity. Bufotalin inhibited pAPN activity with K

i
values in the submicromolar range and an uncompetitive inhibition mechanism; it also inhibited porcine aminopeptidase A (pAPA) activity, but with a classical reversible competitive inhibition mechanism. In addition, we determined the effect of bufotalin on the viability/metabolism of APN+ A549, H292, MeWo and CT26 cancer cells. Bufotalin was cytotoxic in a dose dependent manner; the highest cytotoxicity was detected in A549 cells, the cells with the highest APN activity. Thus, tumor cell line sensitivity to the cytotoxic effect of bufotalin correlates with cell surface APN activity.
Sustainable Posthumanism. Ethical Nudging and Normative Robomorphing
Authors: Costantini Cristina
Published: May 2023

The essay moves from a conceptual dramatization of the ‘otherification’ of the human being towards the tentative solution of all the habitual juxtapositions created by modern rationality between human/non-human, organic/inorganic, life/death, natural/artificial, animate/inanimate. A new possible vision, substantiated by literature and supported by a philosophical critical thought, transfigures the same idea of matter, opening the way to a new form of materialism which acknowledges the vitality, the liveliness of the stuff and accepts infinite bio-possibilities. The horizon of a possible ‘humanistic inhumanism’ is explored through the paradigmatic and performative representation offered by Ali Abbasi’s wonderful film ‘Border’, where montage becomes a philosophical tool to question not only the concrete potentiality of a completely reversed post-human semiotic order, but also the current normalization of ethical behaviour. All these arguments foster an articulated reflection on the transformations needed to provoke a ‘regenerative apocalypse’ of Politics and Governance for the promotion of a counter-ethic of interconnectedness.
Minding the Shift: Some Thoughts on the Human and the Not Too Human Mind
Authors: Gaakeer Jeanne
Published: May 2023

Software systems that claim to think for themselves may prove to be Frankenstein’s nightmare come true. When Amazon used algorithms to read digital letters of job applicants, it turned out that mentioning women sports in the category of one’s favourite leisure activities was detrimental to getting the job, i.e., the algorithm favoured male applicants. What if AI becomes able to and will in fact take over cars, elevators and other electronic devices with devastating results for their human owners or operators? In this article, I aim to address the differences between, and the possible clashes of the human and the AI minds (and their souls and hearts) by means of some examples, including a.o., drones, ADS (automatic driving systems) and our recent Artificial Friend, Kazuo Ishiguro’s fictional robot Klara, and I do so by focussing on the narratives involved, on the view that new technologies need a legal hermeneut. This article is inspired, firstly, by the novelist Samuel Butler and the today not so fictional question that he raised, i.e., whether “because mechanical life is a very different thing from ours, therefore it is not life at all?” (Samuel Butler, Erewhon [1872]. Harmondsworth UK: Penguin, 1954, 175), because Butler adds that if it is considered life it could have a will of its own as well and that may lead to dire consequences also from a point of view of law; secondly, because the topic of AI also invites us to consider the interdisciplinary question why new technologies need the humanities. As the philosopher Edmund Husserl claimed, a determination of the world by the positive sciences as took place in the second half of the nineteenth century occasioned “an indifferent turning-away from the questions which are decisive for a genuine humanity. Merely fact-minded sciences make merely fact-minded people” (Edmund Husserl, The Crisis of European Sciences and Transcendental Phenomenology, An Introduction to Phenomenological Philosophy [1954], trans. David Carr. Evanston, Ill.: Northwestern University Press, 1970, 6).
Of Sexbots, Cyborgs and Artificial Intelligence: Articulations of the Posthuman Subject in Jeanette Winterson’s Frankissstein: A Love Story
Authors: Onega Susana
Published: May 2023

Jeanette Winterson’s latest novel, Frankissstein: A Love Story (2019), was written as a contribution to the world-wide celebrations of the second centenary of the publication of Mary Shelley’s Frankenstein. Evincing the characteristic excessiveness and parodic stance of the postmodern romance, it alternates two interlocked story lines. The first, narrated by Mary Shelley, is situated during her own life span and populated by Mary herself, Percy Bysshe Shelley, Lord Byron, John William Polidori and Claire Clairmont. The second, situated in 2018, is narrated by Dr Ry Shelley, a transgender medical doctor who sells body parts to Prof. Victor Stein, a cutting-edge researcher in Artificial Intelligence. The essay argues that for all its parodic doubleness, temporal circularity, thematic enmeshment and palimpsestic structure, the novel draws a clear-cut distinction between the Idealist conception of subjectivity endorsed by the male Romantic poets that leads to Prof. Stein’s transmodern conception of a future universe colonised by bodiless enhanced humans, and Mary Shelley’s affectively charged conception of embodied subjectivity that foreruns Ry Shelley’s posthuman conception of fluid subjectivity.
Homo and heterometallic ruthenium and platinum complexes with multiple targets for therapeutic applications: a review
Authors: De Senjuti , Nag Samik
Published: May 2023

We are now well-positioned to comprehend carcinogenesis at a molecular level in greater detail due to significant technological advancements. Additionally, we are now able to rationally design and develop drug molecules with the ability to either selectively enhance or disrupt important biological processes, maximizing their therapeutic potential. This has heralded a new era in drug design. The heterometallic ruthenium–platinum complexes can be used as anticancer, photodynamic therapy, diabetes treatment, and molecular sensors for thiol-containing peptides due to their multifunctional interactions with nuclear DNA, mitochondrial DNA, RNA, and proteins. Compared to cisplatin and its Ru-based monometallic precursors, a significant number of reported ruthenium–platinum complexes exhibit enhanced cytotoxicity and tumor selectivity. Due to the covalent binding of the cis-PtIICl2 moiety to DNA, photoactive Ru(II)–Pt(II) complexes were designed to prelocalize a photodynamic therapy agent at the site of action. The development of ruthenium–platinum-based heterometallic complexes has recently advanced, opening up new avenues for the development of drugs that are more efficient. Metal complexes’ potential as important cancer therapeutic agents will be the primary focus of this review. The development of ruthenium and platinum-based mono and mixed-metal complexes with therapeutic and biomedical applications are discussed in detail in this article.
DESLOCAMENTOS, OBSERVÂNCIAS E CARTOGRAFIAS NA ARTE CONTEMPORÂNEA (DESLOCC) PARA UMA CIDADE MÚLTIPLA E VÍVIDA
Authors: Gonçalves Eduarda (Duda) Azevedo
Published: May 2023

O artigo versa sobre as proposições artísticas do grupo de pesquisa DeslOCC (CNPq/UFPel), revelando as táticas para prospectar a cidade de Pelotas e arredores. As produções propositivas apresentadas no texto partem dos Cartões de vista mirantes e os movimentos conjuntos que desencadeiam o ensaio visual Marambaiar, a ação Arte/Rolê no Buzão, a excursão em Monte Bonito e as cartografias Cartas Moventes. Os processos são descritos e são considerados os teóricos Francesco Careri, Michel de Certeau e a produção artística de Gabriel Orozco e Hélio Fervenza, evidenciando as maneiras pelas quais a cidade, a vizinhança, vai sendo reinventada e ampliada, ao instaurar um modo de fazer arte no extremo sul do Brasil.Palavras-chave: Caminhar junto; Arte contemporânea; Arte propositiva; Deslocamentos.Displacements, Observances and Cartographies in Contemporary Art (DeslOCC) for a Vivid and Manyfold CityAbstract: The article discusses artistic propositions of the research group DeslOCC (CNPq/UFPel), revealing artistic tactics used to prospect the city of Pelotas and surroundings. The art productions presented begin with the Cartões de vista mirantes and the movements in group that trigger the visual essay Marambaiar, the action Arte/Rolê no Buzão, an excursion in Monte Bonito and the cartographies Cartas Moventes. Art processes are described, while considering theorists Francesco Careri, Michel de Certeau, as well as art productions by Gabriel Orozco and Hélio Fervenza, highlighting the ways in which the city, the neighborhood, has been reinvented and expanded, by establishing ways of making art in the extreme south of Brazil. Keywords: Walk together; Contemporary art; Propositive art; Displacements.
Performances colaborativas ou como produzir teorias no movimento
Authors: Blanca Rosa Maria
Published: May 2023

O artigo pesquisa o convívio e a amizade como formas da subjetividade da produção da arte contemporânea, e seus atravessamentos com a ar te do queer e feminista, discutindo categorias como espaço seguro, trabalho colaborativo, performances colaborativas, identidade coletiva, écharpe queer e teoria em deslocamento. Desenvolve uma genealogia das práticas colaborativas e feministas. Estudam-se projetos coletivos como AIR -Ar tists in Residence-, Womanhouse do Programa Feminista de Ar te do Instituto de Ar te da Califórnia, Guerrilla Girls, COLAB, Fashion Moda e ACT-UP (AIDS Coalition to Unleash Power), para finalmente tencionar a performance colaborativa do Coño Insumiso, realizada no âmbito do congresso 13ª Marcha Mundial das Mulheres e do 11º Seminário Internacional Fazendo Gênero, em Florianópolis, Brasil, em 2017, em solidariedade internacional à performance andaluza do Sagrado Coño Insumiso realizada no contexto espanhol, em 2014.Palavras-chave: Arte feminista e queer; Amizade; Convívio; Solidariedade internacional; Subjetividades Colaborative Performances or How to Produce Theories in MovementAbstract: The article researches conviviality and friendship as forms of subjectivity in the production of contemporary art, and its crossings with queer and feminist art, discussing categories such as safe space, collaborative work, collaborative performances, collective identity, écharpe queer and theory in displacement. It develops a genealogy of collaborative and feminist practices. Collective projects such as AIR -Artists in Residence-, Womanhouse from the Feminist Art Program of the California Institute of Art, Guerrilla Girls, COLAB, Fashion Moda and ACT-UP (AIDS Coalition to Unleash Power) are studied to finally intend the performance collaborative ef fort by Coño Insumiso, held within the scope of the 13th World March of Women congress and the 11th International Seminar Doing Gender, in Florianópolis, Brazil, in 2017, in international solidarity with the Andalusian performance of Sagrado Coño Insumiso held in the Spanish context, in 2014. Keywords: Feminist and queer art; Friendship; Conviviality; International solidarity; Subjectivities
"CO": prefixo latino que traz consigo o sentido de "com"
Authors: Biancalana Gisela Reis
Published: May 2023

O trabalho aponta os desafios da criação COnjunta e apresenta duas performances artísticas, Aqui ou AliXo e Rubra Fluidez, desenvolvidas por integrantes do Laboratório de Pesquisa em Performance Arte e Cultura (LAPARC/ UFSM). Ao discutir as práticas de colaboração e entrecruzamentos de saberes, ou seja, “saberes-fazeres advindos das experiências conjuntas”, desenvolve o pensamento sobre o termo colaboração em artes e o modo de fazer arte junto, debruçando-se nas considerações do norueguês Florian Schneider, da boliviana Maria Galindo, entre outros, assim como a evidência de outros termos que versam sobre a produção artísticas com autoria compartilhada.Palavras-chave: Criação COnjunta; Performance; Colaboração; autoria. “CO”: Latin Prefix that carries a sense of “WITH” Abstract: The work points to the challenges of joint creation and presents two artistic performances, Aqui ou AliXo and Rubra Fluidez, developed by members of the Research Laboratory in Performance Art and Culture (LAPARC of the Federal University of Santa Maria/UFSM, Brazil). When discussing the practices of collaboration and knowledge intersections, which is “[the] know-how arising from joint experiences”, the paper ref lects on the term ‘collaboration in the arts’ and ways of making art together, considering Norwegian author Florian Schneider and Bolivian Maria Galindo, among others, as well as other terms that deal with artistic production with shared authorship.Keywords: CO; Joint creation; Performance; Collaboration; authorship.
Intervenções urbanas: o processo criativo no contexto artístico contemporâneo
Authors: Hildebrand Hermes Renato , Silva Gil Adeline Gabriela , De Araújo Daniel Paz
Published: May 2023

Pretende-se investigar as condições criativas que se realizam por meio das artes interativas e contemporâneas, no contexto da complexidade, interação, colaboração e com base nas tecnologias emergentes. Ao acompanhar o processo criativo de vários projetos de intervenções urbanas, busca-se levantar dados, para mapear e cartografar territórios que se vinculam às práticas artísticas, de entretenimento e de gestão pública, enfatizando as emergências de padrões estéticos, poéticos e diferentes formas de significação por meio das narrativas digitais. Serão analisadas três intervenções artísticas: Air City: arte#ocupaSM-2012-2013, realizada em Santa Maria – RS, ZL Vórtice, na Zona Leste da cidade de São Paulo – SP e ParaTy - Trilha dos Sete Degraus, na cidade de Paraty – RJ, todas no Brasil. As obras artísticas foram analisadas com base no “Método Cartográfico”, criado por Gilles Deleuze e Félix Guattari (1995) que abordam as dimensões da subjetividade, criatividade e elaboração do conhecimento. Acredita-se que a “desprogramação de processos” por meio da incorporação do imprevisível, apresenta componentes estéticos e poéticos que podem ser destacados ao observarmos os aspectos que compõem estas intervenções.Palavras-chave: Complexidade; cartografia; arte contemporânea; processos de criação; método cartográfico. Urban Interventions: Creative process in the context of contemporary artAbstract: The aim is to investigate the creative conditions which occur through interactive and contemporary arts, in the context of complexity, interaction, collaboration and based on emerging technologies. As we follow the creative process of various urban interventions projects, we seek to collect data to map and [cartographically] map territories that are linked to artistic, entertainment and public management practices, emphasizing the emergence of aesthetic, poetic and differing forms of meaning in digital narratives. Three artistic interventions presented in Brazil will be analyzed: Air City: arte#ocupa-SM/2012-2013, in the city of Santa Maria – RS, ZL Vórtice in the East Zone of the city of São Paulo, SP and ParaTy-Trilha dos Sete Degraus, in the city of Paraty, RJ. The art works were elaborated based on the "Cartographic Method", created by Gilles Deleuze and Félix Guattari (1995) that approach the dimensions of subjectivity, creativity and knowledge elaboration. It is believed that the "deprogramming of processes" through the incorporation of the unpredictable presents aesthetic and poetic components which may be highlighted by observing the aspects that make up these interventions. Keywords: Complexity; Cartography; Contemporary art; Creative processes; Cartographic method.