bluuebunny/crossref_metadata_2025 huggingface dataset:
THE DEVELOPMENT OF ETHNOPHYSICS BASED ENRICHMENT BOOK ON THE PROCESS OF MAKING BRICKS IN MUARO JAMBI REGENCY
Authors: Fadilah Irma , Basuki Fibrika Rahmat , Kurniawan Wawan , Jufrida Jufrida
Published: May 2023

This study aims to develop an ethnophysics-based enrichment book on the brick-making process in Muaro Jambi Regency in order to improve students' cognitive abilities. The research method used is Research and Development and refers to the ADDIE development model (Analysis, Design, Development, Implementation, and Evaluation). The research subjects were material experts, media experts, and students of class XII Science at SMAN 7 Kota Jambi. The research instruments used were interview guidelines, student characteristic questionnaires, observation sheets, expert validation sheets, and perception trial questionnaires. The data obtained were in the form of qualitative data which was analyzed continuously and intensively and quantitative data which were analyzed using descriptive statistics. This enrichment book is written in communicative language equipped with interesting pictures, data, and factual information on bricks in Muaro Jambi Regency. The results of the feasibility test by the material expert validators and the media experts in the first stage were 76% in the good category and in the second stage, it was 97% with the very good category. The results of the student's perception test showed that the ethnophysics-based high school physics enrichment book in the brick-making process in Muaro Jambi Regency was feasible to use with a percentage of 83% which was included in the very good category.
DEVELOPMENT OF SCIENCE LEARNING VIDEO-BASED LOCAL POTENTIAL RIVER TUBING TO IMPROVE CRITICAL THINKING SKILLS STUDENTS OF TEMPUREJO 2 STATE JUNIOR HIGH SCHOOL
Authors: Syam Mahla Noer Rozqiyah , Jannah Ana Wardatul , Hasanah Mifathul , Hidayah Tanti Lutfiatul , Wahyuni Sri
Published: May 2023

River Tubing's local potential-based learning video is an alternative for developing learning tools by implementing local potential into science learning. This research is a development research that uses the Plomp development model which is adjusted to 4 stages. This study aims to describe the validity of River Tubing's local potential-based science learning videos, find out the practicality of River Tubing's local potential-based science learning videos in terms of the implementation of learning using science learning videos, and determine the effectiveness of River Tubing's science learning videos. Tubing's local potential-based science learning video in terms of ability. students' critical thinking and to find out student responses. River Tubing's local potential-based science learning video on substance pressure material in junior high school is valid with a final validity result of 60%-80% in the fairly valid category. Field trials were conducted in class VIII B of SMP Negeri 2 Tempurejo with 32 students. The results of practicality show that the level of implementation reaches a fairly practical category, namely 70% p <80% and the results of the effectiveness of using student critical thinking skills tests and student response questionnaires, student responses to science learning videos based on local potential River Tubing can be said to be good if the student response category is minimal pretty good category.
Escolas primárias rurais no distrito de Paiquerê / Londrina – PR
Authors: Burioli Simone , Pereira Rosemeire Ferreira Lopes
Published: May 2023

O presente trabalho tem como objetivo refletir sobre a história das instituições escolares rurais no distrito de Paiquerê – Londrina – PR, por meio de uma pesquisa documental com fontes primárias - documentos, fotos e bibliografias, sob a perspectiva da Nova História Cultural. Para alcançar tal objetivo questiona-se: Como ocorreu a expansão da escolarização? Qual foi a trajetória de funcionamento de escolas rurais do distrito em questão até o processo de nucleação? Tomamos como recorte temporal inicial o ano de 1940, momento da construção das primeiras escolas rurais no distrito, até 1986, como recorte temporal final, considerando o fechamento da última escola, este período abarca o processo de expansão até o momento da nucleação dessas instituições. Apresentamos a institucionalização das escolas rurais em Londrina e mais detidamente no distrito de Paiquerê, considerada a região mais produtiva e por isso mais atraente aos migrantes, vislumbrando que a abertura de escolas estava ligada ao processo de colonização e aumento de crianças na região. Temos como resultado um quadro de dezenove escolas com suas denominações antigas e atuais, os anos de funcionamento e sua localização. O processo de nucleação e fechamento das escolas rurais se deu pelo mesmo motivo, o êxodo rural, desvalorizando e reforçando a ideia da impossibilidade da educação no meio rural.
“Escola sem partido” e alternativas para uma escola democrática no Brasil
Authors: Santos Júnior Francisco Joatan Freitas , Pinheiro Francisco Felipe de Aguiar , Sousa Joilson Silva de
Published: May 2023

O artigo analisa as propostas educacionais do movimento “Escola sem Partido” e indica alternativas para uma escola democrática no Brasil. O objetivo é apontar as inconsistências teórico-pedagógicas das propostas do movimento “Escola sem Partido”, confrontando-as com as ideias de uma educação popular e democrática, no contexto histórico-político nacional. Parte-se da hipótese de que as propostas do ESP têm fundamentos de natureza autoritária, antidemocrática e anticientífica, beirando o totalitarismo. Adota-se como procedimento metodológico a revisão bibliográfica e a análise documental com uma postura teórico-metodológica alinhada à epistemologia da história, sob a referência do método dialético regressivo de Bloch (2001) e à luz de pressupostos teóricos interdisciplinares dos campos da educação, filosofia e história. Conclui-se que a proposta da Escola sem Partido”, além de inconstitucional, constitui-se numa antipedagogia, ancorada numa filosofia da ordem reacionária e negacionista. Como alternativas democráticas, apontam-se duas propostas pedagógicas contra-hegemônicas: a crítico-social dos conteúdos de Libâneo (2014) e a histórico-crítica de Saviani (2008).
Banco mundial e a educação pública brasileira
Authors: Zanotto Marijane , Hippler Kethlyn Elisa
Published: May 2023

Em sua trajetória, o Banco Mundial passou de uma instituição de suporte financeiro para um gerenciador de políticas educacionais, para garantir a hegemonia econômica própria do sistema capitalista. Diante desse foco, esta pesquisa tem como objetivo compreender os interesses do Banco Mundial em determinar as diretrizes da educação dos países periféricos e quais são os impactos dessa intervenção na política educacional para o ensino fundamental no Brasil. Como metodologia de pesquisa, utilizou-se estudo bibliográfico, fundamentado em autores progressistas, além de análise documental, com foco no estudo do documento “Um Ajuste Justo: análise da eficiência e equidade do gasto público no Brasil”, elaborado pelo Banco Mundial, em 2017. Considerando tal pressuposto, depreende-se que tais movimentos políticos interferem indireta e diretamente nas esferas escolares e na prática pedagógica do professor, atuante em sala de aula, assim como tais prerrogativas ideológicas construíram e embasaram as políticas educacionais brasileiras.
A questão da diversidade no trabalho educativo à luz da pedagogia histórico-crítica
Authors: Viana Marta Loula Dourado
Published: May 2023

Este texto pretende analisar as categorias contradição e totalidade na relação entre universal-singular-particular, na perspectiva do materialismo histórico e da pedagogia histórico-crítica, de modo a identificarmos as contribuições desta relação no trabalho educativo para o desenvolvimento da diversidade humana, de acordo com as particularidades de uma sociedade regida pelo capital. O texto se divide em dois momentos. No primeiro momento discute o duplo sentido do trabalho em Marx. O trabalho enquanto atividade fundamental no processo de transformação do mundo exterior e de si mesmo. Mas que, na sociedade dividida em classes, o indivíduo é apartado do acúmulo social e histórico da humanidade, portanto, impedido de manifestar sua diversidade na plenitude. No segundo momento, busca no trabalho educativo a relação universal-singular-particular de acordo com as categorias contradição e totalidade, ou seja, a forma pela qual o gênero humano contém o indivíduo singular, ao mesmo tempo em que este realiza a universalidade. Esta relação resulta na manifestação da particularidade, que se constitui como mediação e se torna responsável pelo desenvolvimento do indivíduo e de sua diversidade. Por fim, conclui-se sobre as ciladas dos discursos sobre diversidade, bem como a necessidade de pensar a emancipação para além das conquistas dos direitos civis e políticos pelos diferentes grupos sociais e culturais, que apesar de necessárias não correspondem a emancipação humana de modo que o indivíduo manifeste sua diversidade na plenitude.
In Vitro Release Ability of Nanoparticles Poly-Lactic-Co-Glycolic-Acid (PLGA) Gel Containing Pegagan Leaves Ethanolic Extract (Centella asiatica L.)
Authors: Mardiyanto  , Apriani Elsa Fitria , Jati Pandu Kalingga
Published: May 2023

Background: Pegagan (Centella asiatica L.) leaves are proven to contain high concentrations of flavonoid compounds as antioxidants. Flavonoids are unstable compounds due to environmental influences such as light, humidity, pH, and oxygen. The stability of pegagan extract was proven to be improved by making the extract into nanoparticle preparations. Objective: This study aims to formulate nanoparticles of pegagan into gel preparations and determine their release ability with the Franz diffusion test using a cellophane membrane compared to pegagan gel not formulated into nanoparticles. Methods: Nanoparticles were made using poly-lactic-co-glycolic acid polymers and then formulated into gels with various concentrations of Carbopol 934, namely 1, 1.5 and 2%. The gel nanoparticles were then subjected to the characterization of the preparation, stability test and release test of the preparation. Results: A concentration of 1% Carbopol 934 provides the best evaluation of gel preparations where the gel produced was homogeneous, pH was around 6.2, viscosity was 3417.12 cPs, spreadability was 5.1 cm, and adhesion was 209.33 seconds. The stability test showed no significant organoleptic and pH changes (p>0.05). The release kinetics model occurs at zero order. F1 has a higher reaction kinetics constant (k) than the other formulations, so drug release occurs faster. Conclusion: The best formula of pegagan (F1) nanoparticle gel was proven to have good physical stability and release ability.
Characterization of Spanlastic System Loaded Green Tea Extract as Antioxidant for Skin
Authors: Santuso Evelyne , Soeratri Widji , Purwanti Tutiek
Published: May 2023

Background: Green tea possesses abundant polyphenols that exert antioxidant activity. However, green tea’s hydrophilicity and instability limit its penetration into the skin layers. Recently, a non-ionic surfactant-based elastic nanovesicular system called spanlastic can enhance the delivery of hydrophilic and unstable substances. Spanlastic composed of vesicle builder and edge activator, which influence the characteristics of the vesicle.  Objective: The study aimed to evaluate the influence of the ratio of the components on the characterization of green tea extract-loaded spanlastic using three different weight ratio of vesicle builder and edge activator that is 7:3, 8:2, and 9:1. Methods: Spanlastic is prepared by ethanol injection methods using Span 60 as vesicle builder (VB) and Tween® 60 as edge activator (EA). The characterization includes visually observed organoleptic, particle size (PS) and polydispersity index (PDI) using dynamic light scattering, entrapment efficiency (EE) and drug loading (DL) using total phenolic content assay. The most optimum ratio will be tested its zeta potential value using Zetasizer and viscosity using Brookfield Cone and Plate. Results: Selected spanlastic formula composed of Span 60 and Tween® 60 at a weight ratio of 8:2 has given characteristics as follows: entrapment efficiency 60.85±1.70%; drug loading 11.07±0.65%; the particle size is 419.70±7.42 nm; and  PDI value 0.26±0.05. The prepared spanlastic has a greenish liquid form, with a zeta potential value of 28.53±2.78 mV and viscosity of 14.65±0.32 cP. Conclusion: The optimum weight ratio of vesicle builder and edge activator for green tea extract spanlastic is Span 60:Tween® 60 8:2.
Effect of Different Lipid Ratios on Physicochemical Stability and Drug Release of Nanostructured Lipid Carriers Loaded Coenzyme Q10
Authors: Abdulloh Suyuti  , Esti Hendradi  , Tutiek Purwanti
Published: May 2023

Background: For treatment or skin care via topical route, Coenzyme Q10 needs to permeate the epidermis which it is practically insoluble in water and a high molecular weight that make it difficult to penetrate the skin. Nanostructured Lipid Carriers (NLC) is chosen because of its ability to dissolve and solve the problem of low skin permeation. The type and ratio of solid and liquid lipids used in NLC affect the physicochemical characteristics, thus affecting the release profile and system stability. Objective: This study aimed to determine the effect of various ratios of Compritol 888 ATO as solid lipid and Miglyol 812 as liquid lipid on the physicochemical stability and Coenzyme Q10 release profile of NLC system. Methods: NLC was prepared using High Shear Homogenization method with three different lipid ratios. The ratio of Compritol 888 ATO : Miglyol 812 was 70:30, 80:20, and 90:10, respectively. NLC was evaluated for drug release and stability parameters including organoleptic, particle size, polydispersity index (PI), pH, viscosity, assay, and entrapment efficiency. Results: The stability test result for 90 days showed increments in the particle size and viscosity, whereas for assay and entrapment efficiency were decreased. The release test results showed no significant difference in the release parameters of the three tested formulas. Conclusion: During stability evaluation, NLC-CoQ10 systems did not significantly change pH and PI values, but statistically significantly changed particle size, viscosity, assay, and entrapment efficiency. The different in lipid ratios used in the formulas did not show significantly different results for release parameters.
Growth Inhibitory Effects of Red and Yellow Passion Fruits against MRSA and ESBL-producing Bacteria
Authors: Dwiana Aprelita Nurelli , Poernomo Achmad Toto , Nurrosyidah Iif Hanifa , Isnaeni  , Rahmawaty Dian , Kusumawati Idha
Published: May 2023

Background: Red passion fruit (Passiflora edulis Sims) and yellow passion fruit (Passiflora edulis f. flavicarpa) are native Indonesian fruits with numerous health benefits. This study used de Man, Rogosa, and Sharpe (MRS) medium for fermentation. Probiotics are beneficial microorganisms obtained from fermented food or drink (Hamid et al., 2020). Probiotics and lactic acid bacteria, which are known to have various benefits, particularly as antibacterial, are among the active components identified in passion fruit pulp. Objective: This study examinedthe antibacterial activity of red and yellow passion fruits. Methods: Freshly collected passion fruit pulps were fermented in MRS medium in a shaker incubator for 48 hours at 24°C. The filtrates from the fermented broth were tested against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) and extended-spectrum beta-lactamase (ESBL)-producing bacteria. The analyses applied the streak plate method and the total plate count method. Results: The Minimum Inhibitory Concentrations (MICs) of red passion fruit ferment filtrate against MRSA 10 and MRSA 11 were 50% and 60%, respectively, and of yellow passion fruit ferment filtrate against MRSA 10 and MRSA 11 were both 30%. Meanwhile, the MICs of red passion fruit ferment filtrates were 35% against ESBL 41 and ESBL 43 and 25% against ESBL 45 and ESBL 47, whereas the MICs of yellow passion fruit (Passiflora edulis f. favicarpa) ferment filtrates were 25% against ESBL 41 and ESBL 43, and 12.5% against ESBL 45 and ESBL 47. Red passion fruit (Passiflora edulis Sims) and yellow passion fruit (Passiflora edulis f. flavicarpa) ferment filtrates became growth inhibitors against the clinical isolates of MRSA and ESBL-producing bacteria with an optimal fermentation time of 24 hours and an optimal concentration of 75%. Conclusion: The results of this study found that the fermented filtrates of red and yellow passion fruits in MRS media could be developed as an antibacterial against MRSA and ESBL-producing bacteria.
Egg production and egg quality characteristics of Yoruba, Sussex, and Goliath chickens and their crossbred progenies under humid tropical climate
Authors: Ademola Abimbola Alice , Fayeye Timothy Rotimi , Akintunde Adeyinka Oye , Chimezie Victoria O.
Published: May 2023

Yoruba Ecotype Chicken (YEC) is characterized by hardiness, and better adaptation to prevailing tropical environment. However, its poor egg production has hindered its utilization for commercial production. Crossbreeding is a major tool used in improving desired traits in animals. The objective of the study was to evaluate egg production and quality characteristics in YEC and its crosses with Goliath (GG) and Sussex (SS). The study investigated egg production and egg quality characteristics using 120 sixteen-week-old YEC and its crosses. The findings of the study showed that egg parameters were significantly higher (p<0.05) and maturity occurred earlier (154 days) in YECxSS than in YECxYEC (146 days) and other YEC crosses. The study concluded that cross breeding improved egg production of YEC. Crossbred YEC x SS is therefore recommended for egg production in Nigeria.
PROPUESTA DE DOSIER TEMÁTICO: SALUD Y EDUCACIÓN EN LOS SIGLOS XIX A XXI
Authors: Carrillo Farga Ana María , Martínez Moctezuma Lucia
Published: May 2023

Propuesta de Dosier Temático: Salud y Educación en los siglos XIX a XXI.
Observations of transoceanic movements by Nankeen Kestrels Falco cenchroides and a catalogue of terrestrial birds interacting with offshore vessels in Bass Strait, Australia
Authors:   Institute for Marine and Antarctic Studies, University of Tasmania, Battery Point 7004 TAS, Australia, Viola Benjamin
Published: May 2023

How terrestrial avifauna interact with offshore infrastructure is relatively understudied. The migratory pathway and movements over Bass Strait (an expanse of ocean between Victoria and Tasmania, Australia) for many terrestrial species remains poorly known. Whilst working in Bass Strait, I observed multiple terrestrial species flying over deep offshore waters, up to distances of 35 nautical miles from the nearest coastline. Some of these species utilised offshore vessels as temporary refugia. Of particular note are several observations of Nankeen Kestrels Falco cenchroides. These observations are discussed, alongside an empirical list of species observed during my engagement with the offshore industry.
Permissive Hypotension Strategy in Open-surgery of Abdominal Aortic Aneurysm
Authors: Budiman Alvian Chandra , Ganitafuri Handayu , Putro Bambang Novianto
Published: May 2023

Background: Open-surgery in patients with aortic aneurysms has always been a challenge for every anesthesiologist. The risk of massive bleeding, hemodynamic instability, and peripheral perfusion insufficiency are some of the reasons for the need of appropriate perioperative management. The purpose of this case report is to describe the permissive hypotension strategy in open-surgery of abdominal aortic aneurysm. Case Ilustration: A 65-year-old man with radiologic findings of an aneurysm in the abdominal aorta at 3rd-4th lumbar vertebrae level was planned for open-surgery aneurysmectomy and aortic graft. Pre-operative assessment concluded the physical status of ASA III. Patient was planned to receive general anesthesia. Invasive hemodynamic monitoring was performed by placing an arterial line and a central venous catheter. Just before the aortic clamp procedure, permissive hypotension strategy was started by lowering systolic blood pressure using titrated doses of nitroglycerin with target MAP of >60 mmHg. Bleeding management was carried out with intravascular fluid resuscitation until the CVP target of 7-8 mmHg was achieved. When the aortic clamp was released, titrated dose of norepinephrine was administered with target MAP of 65-75 mmHg. Post-operatively, the patient was admitted to the ICU. The patient was discharged on the seventh post-operative day. Conclusion: This case demonstrated the successful perioperative management of an open surgery aneurysmectomy by maintaining the hemodynamic stability of the patient using permissive hypotension strategy. The successful stabilization of patient’s hemodynamic state during surgery resulted in a good and fast post-operative outcome and recovery.
Estrategias de sostenibilidad para la mayor competitividad en la industria cementera de México
Authors: Angulo Patricia , Ochoa Carlos
Published: May 2023

El objetivo de esta investigación es identificar y discutir las estrategias sostenibles más ecoeficientes para aprovechar o reducir emisiones de NOX, SOX y polvos de SiO2 en la fabricación de cemento, con el objetivo de mejorar la competitividad en la industria cementera de México. El diseño de investigación fue cualitativo, observacional y deductivo. Los resultados mostraron que los biorreactores de residuos de SOx tienen mayor ecoeficiencia; seguido de los domos para capturar y aprovechar el SiO2 y los filtros de mangas. Estas estrategias son efectivas para contaminantes específicos derivados de la producción de cemento. Este estudio indaga en un tema escasamente abordado en México, la sostenibilidad del cemento. Al aplicar estas estrategias, el sector cementero mexicano impulsaría su competitividad empresarial.
Buku Ajar Rumput Laut dan Produk Olahannya
Authors:   Universitas Muhammadiyah Sidoarjo, Saidi Ida Agustini , Azara Rima
Published: May 2023

Rumput laut adalah salah satu sumberdaya hayati yang terdapat di wilayah pesisir dan laut. Dalam bahasa Inggris, rumput laut diartikan sebagai seaweed. Sumberdaya ini biasanya dapat ditemui di perairan yang berasosiasi dengan keberadaan ekosistem terumbu karang. Rumput laut alam biasanya dapat hidup di atas substrat pasir dan karang mati. Beberapa daerah pantai di bagian selatan Jawa dan pantai barat Sumatera, rumput laut banyak ditemui hidup di atas karang-karang terjal yang melindungi pantai dari deburan ombak.
TEKNOLOGI SEBAGAI MEDIA PEMBELAJARAN PENDIDIKAN AGAMA ISLAM DI ERA REVOLUSI INDUSTRI 4.0
Authors: Khojir Khojir , Khoirunnikmah Ifah , Syntha Nela
Published: May 2023

Di era revolusi industri 4.0, perkembangan zaman pesat ditandai dengan kemajuan teknologi. Hal tersebut juga sampai kepada dunia pendidikan bahkan dalam pendidikan agama Islam. Dalam pengadaptasiannya tentu dibutuhkan metode yang tepat serta dukungan dari media pembelajaran yang memadai agar pelaksanaannya dapat berjalan dengan baik dan efektif. Sehingga tujuan pembelajaran dapat dicapai. Tujuan penelitian ini adalah untuk menganalisis  peran media dalam pembelajaran PAI, media yang dapat digunakan dengan memanfaatkan teknologi yang berkembang di saat ini. Metode penelitian ini adalah metode kualitatif berjenis library research (studi literatur). Penelitian kepustakaan ini dengan teknik analisis data dekriptif analisis dengan pengumpulan data dari jurnal dan buku yang relevan. Hasil penelitian menggambarkan bahwa media memiliki pengaruh dalam pelaksanaan pembalajaran, serta penggunaan teknologi yang tepat akan membuat suatu media menjadi lebih efesien untuk mendukung proses pembelajaran yang cakupannya menjadi lebih luas.
A Study on Islamic Psycho-Spiritual Therapy on Recovered Adolescent Addicts
Authors: Ismail Nik Ahmad Hisham , Haris Ridwan Haris , Kassim Siti Kholijah , Awang Mat Muhamad Zahiri
Published: May 2023

Therapeutic intervention on drug addiction with a spirituality approach is interesting to pursue since many studies have produced various results. The focus of this study is on psycho-spiritual problems on individuals who had experienced drug addiction. The problems are loss of awareness and mind, physical and mental weakness, anti-social behaviors and problems in the school. Thus, a more in-depth study of the role of spirituality on this problem in increasing mentality, conscious mind and behaviors as a normal personality. To accomplish this, the researchers explored four individuals who had recovered from an addiction and had undergone Islamic therapeutic intervention at Inabah Centre in Tasikmalaya and Madani Health Care in Jakarta, Indonesia. The findings revealed that they gained enlightenment and consciousness, were reflective and regretful, had self-confidence and were persistent in doing good deeds after going through the recovery process. All aspects of the findings were generated into four themes, namely reflection feeling (RF), insight awareness (IA), expression attitude (EA), and brightness image (BI). Some aspects of psycho-spiritual from Islamic perspective were also explained in the discussion to make it a valuable force in preventing, treating and handling the addiction in society.
A Student-Centered Teaching and Learning Approach Among Excellent Teachers of Islamic Education
Authors: Jasmi Kamarul Azmi , Sahran Rasidah Bt , Nazim Muhamad Amirul Amin Mohamad
Published: May 2023

The role of Islamic Education teachers in imparting knowledge needs to be refined in line with the transformation of the country's education. The implementation of a student-centered teaching and learning approach can have a positive impact on students in improving the quality of knowledge achievement. Therefore, teachers need to equip itself with various pedagogical knowledge, especially student-centered teaching and learning. The purpose of this writing is to explore the student-centered teaching and learning approach among excellent teachers of Islamic education in secondary schools. This writing is done through a qualitative research methodology using interview data as the main data and supported by observation data and document analysis. Excellent teachers of Islamic education selected from eight schools are study participants along with 40 study informants. Along with interview data, there are eight observation data and eight document analysis data. All 56 verbatim were compiled and analyzed using NVivo 20 software to build themes and sub-themes of research findings. The results of the study show that there are 22 student-centered teaching and learning methods and techniques that form a pattern. This finding can produce a Student-Centered teaching and learning approach Model among Excellent teachers of Islamic education in secondary schools.
Electrical Properties of Preparing Biodegradable Polymer Blends of PVA/Starch Doping with Rhodamine –B
Authors: Sweah Zainab J. , Malik Fatima hameed , Abdul Karem Alyaa
Published: May 2023

This research focuses on the characteristics of polyvinyl alcohol and starch polymer blends doping with Rhodamine-B. The polymer blends were prepared using the solution cast method, which comprises 1:1(wt. /wt.).  The polymer blends of PVA and starch with had different ratios of glycerin 0, 25, 30, 35, and 40 % wt. The ratio of 30% wt of glycerin was found to be the most suitable mechanical properties by strength and elasticity. The polymer blend of 1:1 wt ratios of starch/PVA and 30% wt of glycerin were doped with different ratios of Rhoda mine-B dye 0, 1, 2, 3, 4, 5, and 6% wt and the electrical properties of doping biodegradable blends were studied. The ratio of Rhodamine-B 5% wt to the polymer blends showed high conductivity up to 1×10-3. In general, the electrical conductivity was increased with high temperature, which is similar to the behavior of semi-conductive polymers.
This work focuses on the characteristics of polymer blend based on starch and polyvinyl alcohol doping with Rhodamine-B. the polymer blends were prepared using the solution cast method, which comprising 1:1(wt./wt.). ratio starch and   polyvinyl alcohol and different ratio of glycerin (0, 25, 30, 35,and 40) %. The ratio of 30% of glycerin was found to be the most suitable mechanical properties. The polymer blend of 1:1 starch/PVA and 30%of glycerin were doped with different ratio of Rhoda mine-B dye (0, 1, 2, 3, 4, 5, and 6%) and the electrical properties of doping biodegradable blends were studied. The ratio of Rhodamine-B 5% to the polymer blends was high conductivity up to 1×10-3. In general, the electrical conductivity was increased with high temperature this is similar to the behavior of semi-conductive polymers.
This work focuses on the characteristics of polymer blend based on starch and polyvinyl alcohol doping with Rhodamine-B. the polymer blends were prepared using the solution cast method, which comprising 1:1(wt./wt.). ratio starch and   polyvinyl alcohol and different ratio of glycerin (0, 25, 30, 35,and 40) %. The ratio of 30% of glycerin was found to be the most suitable mechanical properties. The polymer blend of 1:1 starch/PVA and 30%of glycerin were doped with different ratio of Rhoda mine-B dye (0, 1, 2, 3, 4, 5, and 6%) and the electrical properties of doping biodegradable blends were studied. The ratio of Rhodamine-B 5% to the polymer blends was high conductivity up to 1×10-3. In general, the electrical conductivity was increased with high temperature this is similar to the behavior of semi-conductive polymers.
Some Types of Mappings in Bitopological Spaces
Authors: Ashaea G. S. , Yaqoub Yousif
Published: May 2023

This work, introduces some concepts in bitopological spaces, which are nm-j-ω-converges to a subset, nm-j-ω-directed toward a set, nm-j-ω-closed mappings, nm-j-ω-rigid set, and nm-j-ω-continuous mappings. The mainline idea in this paper is nm-j-ω-perfect mappings in bitopological spaces such that n = 1,2  and m =1,2 n ≠ m. Characterizations concerning these concepts and several theorems are studied, where j = q , δ, a , pre, b, b.
Gain neuromodulation mediates perceptual switches: evidence from pupillometry, fMRI, and RNN Modelling
Authors: Wainstein Gabriel , Whyte Christopher , Martens Kaylena Ehgoetz , Müller Eli , Munn Brandon , Medel Vicente , Anderson Britt , Stöttinger Elisabeth , Danckert James , Shine James
Published: May 2023

Perception is thought to rely upon evolving activity within a recurrent, distributed thalamocortical network whose interconnections are modulated by bursts of ascending neuromodulatory neurotransmitters, such as noradrenaline. To test this hypothesis, we leveraged a combination of pupillometry, fMRI and recurrent neural network modelling of an ambiguous figures task. Qualitative shifts in the perceptual interpretation of an ambiguous image were associated with peaks in pupil diameter, an indirect readout of phasic noradrenergic bursts. Based on previous modelling work, we hypothesized that increases in neuromodulatory tone led to neural gain alteration so as to causally mediate perceptual switches. To test this hypothesis, we trained a recurrent neural network to perform an analogous perceptual categorisation task, and then manipulated the gain of the RNN to mimic the effect of neuromodulators, such as noradrenaline. As predicted, we observed an earlier perceptual shift as a function of heightened gain. Leveraging a low-dimensional readout of the RNN dynamics, and a measure of the energy landscape traversed by the dynamics, we developed two novel predictions: perceptual switches should co-occur with peaks in low-dimensional brain state velocity and with flattened energy landscape dynamics. We used whole-brain fMRI data to confirm these predictions. These results confirm the core role of the neuromodulatory system in the large-scale network reconfigurations that mediate perceptual switches.
Mobile Application and Advanced Analytics in Wound Care: Variable Predictors of Wound Evolution in a Public Intermediate Hospital
Authors: Reifs David , Casanova-Lozano Lorena , Reig-Bolaño Ramon , Grau-Carrion Sergi
Published: May 2023

Background: Chronic wounds are one of the most frequent complications of pathologies such as diabetes mellitus, peripheral neuropathy, atherosclerosis, and infections. Early diagnosis and effective treatment are required to avoid later complications leading to infections or amputations. The early assessment of this type of wound is crucial when detecting patterns that require unique and rapid care.
Methods: In the present study, 2,750 wound samples consisting of images and anamnesis taken by Hospital Santa Creu de Vic with the Clinicgram® application over three years were captured. The area’s evolution as an indicator of healing was observed between the different characteristics obtained from the application. Two ratios are calculated corresponding to the healing rate and healing time, which refer to the percentage of wounds that reduce their area 50% after four weeks. It has also been considered that necrotic tissue does not increase, and the wound does not become infected. These ratios were compared between etiologies and treatments and the different criteria of the Resvech scale. A Kruskal-Wallis test and ANOVA were performed to assess whether there are statistically significant differences between the groups of samples corresponding to the calculated ratios between the different Resvech parameters. P-values of less than 0.05 in all of them indicate that the groups come from statistically different distributions.
Results: A strong correlation between size, edges and exudate with healing results was observed in patients with venous ulcers (24.44%) and traumatic ulcers (29.73%). Mean of 4 weeks of healing time for wounds between 64cm2 and 100cm2, five weeks for damaged edges and three weeks for wounds with the presence of epithelial tissue.
Conclusion: The importance of systematic data collection using applications like Clinicgram® incorporated into clinical practice is justified to record the variables with which these conclusions can be obtained. Wound assessment variables in elderly patients are correlated and impact on the healing process.
Convolutional neural network classifier incorporating misclassification information
Authors: Hu Junying , Fei Rongrong , Du Fang , Chang Peiju , Zhang Jiangshe
Published: May 2023

In this paper we introduce misclassification information for the improved training of convolutional neural network classifiers (CNNCs) for image recognition. We construct a additional autoencoder neural network, called tutor, that forces the CNNCs to learn the difference between the misclassified picture and the picture corresponding to the misclassified category. Making full use of the classification results to guide the CNNCs for purposeful learning is expected to improve the learning efficiency and classification performance. We integrate the proposed tutor into several state-of-the-art CNNCs architectures and demonstrate improvement in their recognition performance on CIFAR-10/100 and MNIST datasets. Our results suggest that making the most of misclassification information to guide the training of the model can lead to significant performance improvement.
Acoustic Signals Based Crowd Analysis and Classification Model
Authors: Swathi H.Y , Shivakumar G
Published: May 2023

The emergences in computing technologies have broadened the horizon for vision-based surveillance, monitoring and control. However, complex and inferior feature learning over visual artefacts or video streams, especially under extreme conditions confine majority of the at-hand vision-based crowd analysis and classification systems. Retrieving event-sensitive or crowd-type sensitive spatio-temporal features for the different crowd types under extreme conditions is highly complex task. Despite numerous efforts in vision-based approaches, the lack of acoustic cues often create ambiguity in crowd classification. In this research, a novel audio-based feature learning model is developed for crowd analysis and classification. In this work, the audio samples (from the input video) were processed for static (fixed size) sampling, pre-emphasis, block framing and Hann windowing, followed by acoustic feature extraction like GTCC, GTCC-Delta, GTCC-Delta-Delta, MFCC, Spectral Entropy, Spectral Flux, Spectral Slope and Harmonics to noise Ratio (HNR). Finally, the extractedacousticfeatures were processed for classification using the random forest ensemble classifier. The audio-basedclassification model yield classification accuracy of 92.67%, precision of 93.80%, sensitivity82.91%, specificity of 90.48% and F-Measure of 0.9239.
Climate change and human health: Estimating district-level health vulnerabilities in the Indian context
Authors: Chaudhry Divya , Mukhopadhyay Indranil
Published: May 2023

Evidence on the health impact of climate change has been extensively documented in recent scholarly literature. In order to mitigate the adverse health effects induced by climate change, the need for conducting vulnerability assessments has been emphasized. A higher vulnerability to climate change is often linked with substantial risks to human lives and built environment. Despite the potential of vulnerability assessments in alleviating risks posed by climate change, only a limited amount of scholarly work in this domain has been conducted in the Indian context. The present research addresses this lacuna and contributes to the limited scholarship on climate change and health vulnerability assessments in India. Drawing on the vulnerability assessment framework introduced by the fourth assessment report (AR4) of the Intergovernmental Panel on Climate Change (IPCC), this paper estimates district-level health vulnerabilities caused by climate change using multi-dimensional indices. The indices are multi-dimensional since they integrate 50 district-level indicators from 8 data sources for all 640 Census 2011 districts. The statistical technique of Principal Component Analysis (PCA) has been used for integrating the indicators. The findings of this paper indicate that nearly 56 percent of India’s population in 344 districts is highly vulnerable to the health impact of climate change. The results also suggest that Uttar Pradesh, Rajasthan, Madhya Pradesh, Jharkhand, Haryana, Himachal Pradesh, Punjab, Uttarakhand, Jammu and Kashmir, and Arunachal Pradesh have the highest number of districts in the top-10 percent vulnerable category. The paper argues that measures to address social determinants of health and strengthen adaptive capacity are needed to reduce health vulnerabilities to climate change.
An oral triple pill-based cocktail effectively controls acute myeloid leukemia with high translation
Authors: Li Mengyuan , Zheng Shuwen , Gong Qinyuan , Zhuang Haifeng , Wu Zhaoxing , Wang Ping , Zhang Xuzhao , Xu Rongzhen
Published: May 2023

Acute myeloid leukemia (AML) is a deadly hematological malignancy characterized by oncogenic translational addiction that results in over-proliferation and apoptosis evasion of leukemia cells. Various chemo- and targeted-therapies aimed at reversing this hallmark, but most show only modest efficacy. Here we report a single oral pill containing low-dose triple small molecule-based cocktail, a highly active anti-cancer therapy (HAACT) with unique mechanisms, that can effectively control AML. The cocktail comprises of oncogenic translation inhibitor Homoharringtonine (HHT), drug efflux pump P-gpi Encequidar (ENC) and anti-apoptotic protein Bcl-2i Venetoclax (VEN). Mechanically, the cocktail potently kills both leukemia stem cells (LSC) and bulk leukemic cells via co-targeting oncogenic translation, apoptosis machinery and drug efflux pump, resulting in deep and durable remissions of AML in diverse model systems. We also identified EphB4/Bcl-xL as the cocktail response biomarkers. Collectively, we for the first time develop an oral triple pill-based cocktail with high efficacy, safety, simplicity for the AML patients, and provide proof of concept that a single pill containing triple combination cocktail is a promising avenue for AML therapy.
Adsorption properties of hollow carbon spheres to gaseous cyclohexane using DFT simulation and experiments
Authors: Zhao Xiaoben , Chen Guanyu , He Song , Sheng Hongliang , Sun Junwei , Wu Xiya , Tian Fuliang , Zhang Xiaoqian
Published: May 2023

The cyclohexane is the common toxic volatiles emitted from the 8 various industry in worldwide leading to environmental degradation and human 9 illnesses. Hence, there is a requirement for an efficient and stable adsorbent for 10 adsorbing these toxic molecules to safeguard human health and the air atmosphere. 11 Hollow carbon spheres (HCS) are a new type of carbon nanomaterial with large specific 12 surface area, low density, and good chemical and thermal stability. In this study, DFT 13 simulations and static-dynamic adsorption studies of cyclohexane were carried out 14 using HCS as the adsorbent material. Among them, static adsorption focuses on 15 adsorption/desorption isotherm, adsorption isotherm model fitting and isosteric heat of 16 adsorption. Dynamic adsorption was mainly studied the effect of initial concentrations, 17 gas flow rate and ambient temperature on adsorption performance. The results showed 18 that HCS exhibited very good performance in cyclohexane adsorption.
A novel spectral clustering algorithm based on neighbor relation and Gaussian kernel function with only one parameter
Authors: Zhou Hao , Wang Zekun , Chen Hongjia , Wang Xiang
Published: May 2023

Spectral clustering has become a prevalent option for data clustering as it performs well on non-convex spatial datasets with sophisticated structures. The spectral clustering effects depend on the construction of the similarity graph matrix. In this paper, in order to further enhance the clustering performance, we propose a novel similarity measure function based on neighbor relations. The proposed method is called SC-NR. It uses the Gaussian kernel function to measure the similarity between two objects. Since Euclidean distance cannot fully reflect the relation between data, this method adds a weight related to the order of nearest neighbors to the distance between two points. The similarity is better expressed by weighted-Euclidean distance. In experiments, we compared the proposed method with the previous works via the external indexes, that is, clustering accuracy (ACC), normalized mutual information (NMI), and F-measure. The comparison of indexes with state-of-the-art methods demonstrates the superiority of our algorithm. The experiment includes 6 synthetic datasets and 12 real-world datasets. For instance, in the PenDigits dataset F-measure metric is 16.50% higher than the current algorithms.
Clinical validation of a next-generation sequencing assay for 17 cancer related mutations in non-small cell Lung cancer
Authors: Xu Bing , Shan Guangyu , Gao Sihang , Wang Yanrong , Wang Weiwei , Pan Xiaoxi , Zhang Dongxing , Lin Lijiao , Gao Jing , Che Nanying , Ji Xiaoyong , Pan Junhua
Published: May 2023

Background Circulating tumor DNA (ctDNA) enables rapid and repeat testing of actionable mutations with fewer side effects compared to tissue biopsy. And the use of next-generation sequencing (NGS) based on ctDNA as a diagnostic tool in clinical settings is growing. We developed a hybridization capture massively parallel NGS assay using ctDNA, USCI-CT, across 20 cancer relevant genes of non-small cell lung cancer (NSCLC). Clinical validations of this assay across 17 mutations were presented.Methods Clinical NSCLC samples and simulated negative and positive cell-free DNA (cfDNA) samples were applied to validate the technical performance of this assay. First, 40 simulated negative control cfDNA samples were used to evaluate the systemic error levels to delimit the limit of detection of variant allele frequency (VAF). And, 92 clinical NSCLC samples were genotyped by USCI-CT and ddPCR to decide the proper limit of VAF, depth of coverage, and the average depth of target regions for confidently detecting mutations for USCI-CT. Second, one simulated negative cfDNA sample and two simulated positive cfDNA samples in seven replicates were used to assess the precision of the assay. Finally, 518 clinical NSCLC samples were recruited to evaluate the analytical sensitivity and specificity of USCI-CT.Results The assay-specific systemic error rate was below 0.20% by sequencing sixty-seven simulated negative control cfDNA samples. The proper cutoff of detection of VAF, coverage of depth of mutation loci, and average depth of target regions were decided at 0.20%, 1000×, and 1400×. The analytical sensitivity and specificity achieved a satisfactory level with 98.32% and 99.85% for single nucleotide variant (SNV) detection and 97.30% and 96.86% for EGFR exon 19 deletions, respectively.Conclusions The results indicated that the USCI-CT assay can reliably detect NSCLC related mutations at 0.20% variant frequency level and provided insights into the incorporation of hybridization captured NGS-based ctDNA assay into oncology clinical settings.
Determinants of Income Inequality in Kobo Town
Authors: Zegeye Tewodros
Published: May 2023

Income inequality is when individuals living in a given country earn disproportionate income levels. This accounts for the presence of high poverty, especially for households with lower incomes. Identifying the factors determining the existence of inequality is essential to reduce income inequality. With this objective, this study analyzes the determinants of income inequality in kobo town. To explore the determinants of income inequality, primary data obtained from the sample households for the city is applied. The inequality situation in this town is analyzed using income distributions, proving that income inequality in the city is high, and the Gini index of income is 0.38. then, marginal effects from the ordered logit model proved that households with houses have a higher probability of being in a high-income group than those who have lived in a rented house to be in a high-income stream. The effects of continuous variable reported as high education level is associated with a high probability of being a higher income earner.