bluuebunny/crossref_metadata_2025 huggingface dataset:
A Balanced Arthroscopic Debridement of the Inner Layer of the Knee Retinaculum Increases the Tibiofemoral Joint Space Width
Authors: Yáñez-Diaz Roberto , Strömbäck Lars , Vergara Francisco , Caracciolo Gaston , Saravia Anthony , Sandoval Carlos , Zamorano Héctor , Abusleme Sebastián , De la Fuente Carlos
Published: January 2022

Introduction. Traditional techniques can enlarge the medial tibiofemoral joint space width (JSW) for meniscal repairs, but a remnant ligament laxity may be developed. Alternatively, the debridement of the inner retinaculum layer may result in a balanced JSW without causing extra-ligament damage (retinaculum layers II and collateral ligament). Purpose. The purpose of this study was to determine whether a concentric arthroscopic debridement of the inner retinaculum layer increases the tibiofemoral JSW in patients with meniscal injuries. Secondarily, we determine whether the increase in JSW is symmetrical between compartments and describe the rate of complications and patient satisfaction. Method. Twenty middle-aged (15 male and five female) patients diagnosed with acute meniscal injury aged 36 ± 12 years were enrolled. The patients were submitted to an arthroscopic debridement of the inner layer of the knee retinaculum for both the medial and lateral compartments. The tibiofemoral JSW was measured intra-articularly using a custom instrument. A two-way ANOVA for repeated measures was used to compare the JSW. A Bland–Altman analysis and test-retest analysis were performed. Results. The JSW increased following the debridement of the inner retinaculum layer, for both the medial and lateral compartments

p
<
0.001

. No complications were identified, and the patients were satisfied with the intervention. The minimal detectable change and bias of the custom instrument were 0.06 mm and 0.02 mm, respectively. Conclusion. The debridement allows a clinically important (>1 mm) symmetric tibiofemoral JSW enlargement. The technique suggests favoring the diagnosis of meniscus injuries and manipulating arthroscopic instruments without secondary complications after one year.
A Case of Autoimmune Hemolytic Anemia after the First Dose of COVID-19 mRNA-1273 Vaccine with Undetected Pernicious Anemia
Authors: Jaydev Fnu , Kumar Vinod , Khatri Jaikumar , Shahani Shobha , Beganovic Sead
Published: January 2022

By this time, multiple vaccines have been approved to limit the spread of SARS-CoV-2 worldwide. These include new-generation vaccines that contain mRNA of the target organism. Some common side effects were identified and reported during phase 3 clinical trials of vaccination, but more rare adverse events were reported in the literature. One such concern is autoimmune conditions that SARS-CoV-2 viral antigens could have possibly incited. We are presenting here a case of a young female with no known autoimmune diseases, diagnosed with autoimmune hemolytic anemia about a week after receiving her first dose of the COVID-19 mRNA vaccine. We discuss the possible culprit for precipitation of autoimmune hemolytic anemia after the SARS-CoV-2 mRNA vaccine, which encodes virus spike protein. This case highlights the importance of being vigilant for identifying rare adverse events that could appear during mass vaccination.
Comparison of Two Algorithms for Multiline Bus Dynamic Dispatching
Authors: Liu Yingxin , Luo Xinggang , Cheng Shengping , Yu Yang , Tang Jiafu , Shang Xuanzhu
Published: January 2022

Dynamic bus scheduling refers to adjusting the departure time according to the latest time‐varying information or adjusting bus speed in the process of operation. These control strategies can prevent bus bunching and alleviate traffic pressure. The paper studies the multiline bus dynamic scheduling with consideration of departure time and speed meanwhile. The hyperheuristic algorithm is proposed, and low‐level heuristics (LLH) operators are designed. The simulation experiment is performed for the passenger flow distribution of different strengths and types of different scenarios. By comparing the experimental results of genetic algorithm (GA) and hyperheuristic algorithm in solving different scenarios, the results show that in smooth, increasing, decreasing, and multiconvex passenger flow mode, the performance of the hyperheuristic algorithm is higher than that of GA. The promotion rate reaches 18∼28%, and especially the average value of the hyperheuristic algorithm designed under multiconvex passenger flow is up to 28.62%, significantly reducing passengers’ waiting time. By comparing the stability of the three passenger flow modes, the results illustrate that the stability of the hyperheuristic algorithm is lower than that of GA. For the smooth passenger flow mode, the stability of medium and lower density of GA is higher than that of the hyperheuristic algorithm. In comparison, the high‐density stability of the hyperheuristic algorithm is better than that of GA.
Research on Influencing Factors of Effective Gas Extraction Radius in Coal Mine Based on Multiple Linear Regression
Authors: Shang Yuqi , Wu Guiyi , Kong Dezhong , Wang Yang , Li Fei
Published: January 2022

In order to analyze the influence degree of different factors on gas extraction radius, on the basis of coal seam gas flow theory and elastic mechanics, considering the influence of coal seepage rate change on gas flow, the COMSOL Multiphysics numerical simulation software is secondarily developed by using the stress-seepage coupling mathematical model of coal and rock containing gas. Taking coal seam No.2 of Juji Coal Mine as an example, the effective extraction radius under different extraction negative pressure, extraction borehole diameter, extraction time, and initial permeability of coal seam are simulated, respectively. Then, the orthogonal test method is used to design different calculation schemes, and the effective extraction radius is used as the judgment index. The simulation software is used to calculate the effective extraction radius corresponding to different influencing factors. SPSS statistical software is used to analyze the parameters. The multivariate linear regression equation of the influencing factors of the effective extraction radius is obtained, and the multivariate linear regression model is established. The results show that the negative pressure of extraction has little effect on the effective extraction radius; the effective extraction radius gradually expands with the increase of extraction time and extraction aperture, but it has certain timeliness. The initial permeability of the coal seam has a great influence on the effective extraction radius. The influence degree of different influencing factors from large to small is the initial permeability of coal seam, extraction time, borehole diameter, and extraction negative pressure. Therefore, the key to improving the effectiveness of gas extraction is to increase the initial permeability of the coal seam before preextraction, ensure sufficient extraction time, appropriately increase the borehole diameter, and improve the negative pressure of extraction. Finally, the gas flow rate is used for a field test, and the measured results are basically consistent with the simulation results, which proves the correctness of the mathematical model of gas-containing coal and the feasibility of using numerical simulation methods to study the effective extraction radius of coal seams.
Natural Fiber Incorporated Polymer Matrix Composites for Electronic Circuit Board Applications
Authors: Chandrika V. S. , Anamika A. , Jeeva C. , Perumal Bhagavathi , Kumar S. Sanal , Roseline J. Femila , Raghavan Ishwarya Komalnu
Published: January 2022

There are many more applications for fibre-reinforced epoxy composites than there are for metals and alloys today. For example, sustainable, recyclable, and biodegradable reinforcements have been used in numerous studies to improve the mechanical and thermal properties of composite materials. It was discovered that the properties of epoxy-based composites could be improved by combining biosolid waste sugarcane bagasse ash fillers, madar fibre, and epoxy resin. Conventional compression molding techniques were used to prepare the sugarcane bagasse ash (SBA) particles and madar fibre-reinforced epoxy resin-based composites (PMCs), which were loaded with varying amounts of fibre and fillers. Hybrid biocomposites were evaluated for mechanical (tensile, flexural, impact, and hardness) and water absorption characteristics. Epoxy matrix composites containing 28 wt.% madar fibre and 7 wt.% sugarcane bagasse ash fillers had tensile, flexural, hardness, and impact values of 61 MPa, 147 MPa, and 54 kJ/m2, respectively.
Evaluation and Optimization of College English Teaching Effect Based on Improved Support Vector Machine Algorithm
Authors: Bao-feng Zhang
Published: January 2022

Improved SVM algorithm improves the efficiency of College English teaching effect evaluation and meets the requirements of College English teaching evaluation. Based on the relevant theories, this paper constructs the evaluation index system with teachers and students as the main body and takes the questionnaire survey results as the input samples of the LSSVM algorithm. Compared with the evaluation accuracy of an optimized BP neural network and the category weighted gray target decision-making method, the results show that the evaluation accuracy of optimized LSSVM algorithm is 96.26%. Taking SIT as an example, this paper uses the optimized LSSVM algorithm to evaluate its teaching effect and obtains that teachers’ literature and teaching contents are important factors to improve the effect of English teaching. Therefore, this paper introduces the intelligent voice system to optimize the English teaching design of SIT. The teaching design is optimized from the dimensions of teaching objectives, learning situation, teaching content, teaching media and curriculum materials, and teaching procedures.
The Effects of In Utero Fetal Hypoxia and Creatine Treatment on Mitochondrial Function in the Late Gestation Fetal Sheep Brain
Authors: Muccini Anna Maria , Tran Nhi T. , Hale Nadia , McKenzie Matthew , Snow Rod J. , Walker David W. , Ellery Stacey J.
Published: January 2022

Near-term acute hypoxia in utero can result in significant fetal brain injury, with some brain regions more vulnerable than others. As mitochondrial dysfunction is an underlying feature of the injury cascade following hypoxia, this study is aimed at characterizing mitochondrial function at a region-specific level in the near-term fetal brain after a period of acute hypoxia. We hypothesized that regional differences in mitochondrial function would be evident, and that prophylactic creatine treatment would mitigate mitochondrial dysfunction following hypoxia; thereby reducing fetal brain injury. Pregnant Border-Leicester/Merino ewes with singleton fetuses were surgically instrumented at 118 days of gestation (dGa; term is ~145 dGA). A continuous infusion of either creatine (

n
=
15

; 6 mg/kg/h) or isovolumetric saline (

n
=
16

; 1.5 ml/kg/h) was administered to the fetuses from 121 dGa. After 10 days of infusion, a subset of fetuses (8 saline-, 7 creatine-treated) were subjected to 10 minutes of umbilical cord occlusion (UCO) to induce a mild global fetal hypoxia. At 72 hours after UCO, the fetal brain was collected for high-resolution mitochondrial respirometry and molecular and histological analyses. The results show that the transient UCO-induced acute hypoxia impaired mitochondrial function in the hippocampus and the periventricular white matter and increased the incidence of cell death in the hippocampus. Creatine treatment did not rectify the changes in mitochondrial respiration associated with hypoxia, but there was a negative relationship between cell death and creatine content following treatment. Irrespective of UCO, creatine increased the proportion of cytochrome c bound to the inner mitochondrial membrane, upregulated the mRNA expression of the antiapoptotic gene Bcl2, and of PCG1-α, a driver of mitogenesis, in the hippocampus. We conclude that creatine treatment prior to brief, acute hypoxia does not fundamentally modify mitochondrial respiratory function, but may improve mitochondrial structural integrity and potentially increase mitogenesis and activity of antiapoptotic pathways.
Donor-Derived Urothelial Carcinoma in Renal Transplant Recipients
Authors: Qian Zhiyu , Chou Emily , Yang Jing , Zhang Hanwei , Ye HuiHui , Liu Sandy T. , Chin Arnold I.
Published: January 2022

Cancer is a significant cause of morbidity and mortality in recipients of renal transplantation. The vast majority develop from recipient origins, whereas donor-derived malignancies are exceedingly rare. We report 2 cases of poorly differentiated donor-derived urothelial carcinoma (UC) in renal transplantation recipients. The first patient underwent a living-related-donor renal transplantation 24 years prior and presented with back pain, hematuria, and rising creatinine and was found to have a 14 cm mass in the renal allograft with regional lymphadenopathy and liver metastases. Pathology showed UC with small-cell differentiation. The second patient presented with hematuria and rising creatinine and was initially found to have muscle invasive bladder cancer seven years after a deceased donor renal transplantation. Nine months after radical cystectomy, a large 9 cm mass was found on his allograft, for which radical nephrectomy and excision of prior ileal conduit was performed. Pathology showed UC with sarcomatoid differentiation. Short tandem repeat (STR) genotyping confirmed donor-derived origins. Both patient tumors expressed PD-L1 suggesting an additional therapeutic avenue for these rare tumors.
Giant Parathyroid Adenoma-Associated Fracture, Not All Lytic Bone Lesions are Cancer: A Case-Based Review
Authors: Alvarez-Payares Jose C. , Ribero Marcel E. , Ramírez-Urrea Sara , Fragozo-Ramos María C. , Agámez-Gómez Jose E. , Román-González Alejandro , Arias Luis F. , Arenas Roberto Benavides , López-Urbano Fernando
Published: January 2022

Introduction. Due to the early diagnosis of primary hyperparathyroidism the musculoskeletal manifestations of this disease are becoming less frequent. When this disease manifests secondary to a giant adenoma, it presents with more aggressive symptoms and can have important repercussions such as the hungry bone syndrome after parathyroidectomy. There are few reported cases of hyperparathyroidism secondary to a giant adenoma in the literature, as the presence of a brown tumor is often misinterpreted as a metastatic lesion from an unknown primary tumor. Methods. We describe a case and performed a literature review to identify all case reports. A literature search was carried out on PubMed/MEDLINE and EMBASE bibliographic databases. All available studies from May 2009 to May 2021 were included. Data were tabulated, and outcomes were cumulatively analyzed. Results. Twenty-four cases of primary hyperparathyroidism due to giant adenoma have been described; the majority were women, with a mean age of 52 years. They presented with heterogeneous symptoms such as palpable nodules (45%), bone pain (33%), brown tumor (12.5%), asymptomatic (12.5%), metabolic profile with a mean calcemia of 13.8 mg/dL, PTH 1109 ng/L, and mean tumor weight of 47.24 g. Conclusion. Primary hyperparathyroidism due to giant adenoma increases the risk of developing potentially serious postoperative complications such as hungry bone syndrome. This implies the need of implementing preventive measures comprising administration of intravenous zoledronic acid and early supplementation of oral calcium to prevent complications after resection.
[Retracted] (5E,7E)‐4,5,6 Trihydroxy‐3‐(hydroxymethyl)tetrahydro‐2H‐pyran‐2‐ylheptadeca‐5,7‐dienoate from Euclea crispa (L.) Inhibits Ovarian Cancer Cell Growth by Controlling Apoptotic and Metastatic Signaling Mechanisms
Authors: Palanisamy Chella Perumal , Cui Bo , Zhang Hongxia , Jayaraman Selvaraj , Rajagopal Ponnulakshmi , Veeraraghavan Vishnu Priya
Published: January 2022

Bioactive compound (5E,7E)‐4,5,6 trihydroxy‐3‐(hydroxymethyl)tetrahydro‐2H‐pyran‐2‐ylheptadeca‐5,7‐dienoate (compound 2) was isolated from Euclea crispa (E. crispa) by the chromatographic methods. Further, the compound was confirmed by spectroscopic techniques such as ultraviolet‐visible (UV/Vis) spectrometer, Fourier transform infrared (FTIR) spectrometer, and 1H and 13C nuclear magnetic resonance (NMR). Compound 2 exhibited a significant antioxidant activity with IC50 values. It restrained the auxesis of HO‐8910 cells in a shot‐dependent mode. CXCR4, HER2, and Akt proteins involved in cell proliferation and metastasis were found to be significantly reduced (p < 0.05). The protein that is responsible for the death of cells (Bcl‐2 and Bcl‐xL) was reduced (p < 0.05), while the protein expression of p53 and caspase‐9 was increased (p < 0.05) in compound 2‐treated HO‐8910 cells. The results of molecular docking analysis showed the binding affinity with CXCR4 and HER2. Thus, compound 2 can serve as a promising chemotherapeutic agent for the intervention of ovarian cancer. The findings of this study conclude that compound 2 from E. crispa might work as a potential antioxidative and chemotherapeutic agent. The in vivo studies and attempts will pave way for this compound to be an effective drug hereafter.
Beurling‐Type Theorem for a Class of Reproducing Kernel Hilbert Spaces
Authors: Wang Zhi-jie , Xiao Jie-sheng , Xu Xian-min
Published: January 2022

In this paper, it is proved that the Beurling‐type theorem holds for the shift operator on a class of reproducing analytic Hilbert spaces.
Bromhexine Hydrochloride Prophylaxis of COVID-19 for Medical Personnel: A Randomized Open-Label Study
Authors: Mikhaylov Evgeny N. , Lyubimtseva Tamara A. , Vakhrushev Aleksandr D. , Stepanov Dmitry , Lebedev Dmitry S. , Vasilieva Elena Yu. , Konradi Alexandra O. , Shlyakhto Evgeny V.
Published: January 2022

Background. Bromhexine hydrochloride has been suggested as a TMPRSS2 protease blocker that precludes the penetration of SARS-CoV-2 into cells. We aimed to assess the preventive potential of regular bromhexine hydrochloride intake for COVID-19 risk reduction in medical staff actively involved in the evaluation and treatment of patients with confirmed or suspected SARS-CoV-2 infection. Methods. In a single-centre randomized open-label study, medical staff managing patients with suspected and confirmed COVID-19 were enrolled and followed up for 8 weeks. The study began at the initiation of COVID-19 management in the clinic. The study was prematurely terminated after the enrollment of 50 participants without a history of SARS-CoV-2 infection: 25 were assigned to bromhexine hydrochloride treatment (8 mg 3 times per day), and 25 were controls. The composite primary endpoint was a positive nasopharyngeal swab polymerase chain reaction (PCR) test for SARS-CoV-2 or signs of clinical infection within 28 days and at week 8. Secondary endpoints included time from the first contact with a person with COVID-19 to the appearance of respiratory infection symptoms; the number of days before a first positive SARS-CoV-2 test; the number of asymptomatic participants with a positive nasopharyngeal swab test; the number of symptomatic COVID-19 cases; and adverse events. Results. The rate of the combined primary endpoint did not differ significantly between the active treatment group (2/25 [8%]) and control group (7/25 [28%]);

P
=
0.07

. A fewer number of participants developed symptomatic COVID-19 in the treatment group compared to controls (0/25 vs. 5/25;

P
=
0.02

). Conclusion. Although the study was underpowered, it showed that Bromhexine hydrochloride prophylaxis was associated with a reduced rate of symptomatic COVID-19. The prophylactic treatment was not associated with a lower combined primary endpoint rate, a positive swab PCR test, or COVID-19 (ClinicalTrials.gov number, NCT04405999).
Highly Sensitive H2 Sensors Based on Co3O4/PEI‐CNTs at Room Temperature
Authors: Gao Laixu , Li Songquan , Xu Xiaoxue , Zou Changwei , Zhang Guo
Published: January 2022

The highly dispersed Co3O4 on the surface of CNTs modified with polyethylenimine (PEI) was synthesized using the hydrothermal method. In the CNT‐Co3O4 composite materials, CNTs not only provide the substrate for the Co3O4 nanoparticles but also prevent their aggregation. Furthermore, the interaction between Co3O4 and CNTs modified with polyethylenimine (PEI) helps to improve the gas sensing performance. In particular, the CNT‐Co3O4 composite synthesized at 190°C shows the outstanding sensitive characteristics to H2 with a lower detection limit of 30 ppm at room temperature. The obtained CNT‐Co3O4 sensor displays excellent selectivity and stability to H2. The energy band model of the conductive mechanism has been built to explain the resistance change when the gas sensor is exposed to the H2. Hence, the CNT‐Co3O4 composite material presents highly promising applications in H2 gas sensing.
Antidesma thwaitesianum Müll. Arg. Fruit Juice, Its Phytochemical Contents, Antimicrobial Activity, and Application in Chiffon Cake
Authors: Tinchan Patcharaporn , Sirijariyawat Arpassorn , Prommakool Arunya , Phattayakorn Kriangkrai , Pheungsomphane Soukbandith , Tayuan Chintana
Published: January 2022

Antidesma thwaitesianum Müll. Arg. or Mao is well-known in Thailand for its use in soft drinks and wine. This study investigated the potential of its fruit juice as a food preservative based on its antimicrobial activity against food-borne pathogens and spoilage. The fruit juice had antibacterial activity against Bacillus cereus TISTR1527, Staphylococcus aureus TISTR2329, Listeria monocytogenes DMST17303, Pseudomonas aeruginosa TISTR357, Salmonella Typhimurium DMST562, and Escherichia coli TISTR074. The minimum inhibitory concentration ranged from 25 to 100 mg/ml. Of significance was that the juice had excellent antifungal activities against Aspergillus flavus TISTR3135 and Penicillium digitatum ATCC10030. Furthermore, the fruit juice increased the lag time of spore germination of P. digitatum. Analysis of the phytochemical contents of the juice showed that the total phenolic and flavonoid contents were 20.07 mg GAE/g and 3.57 mg QE/g, respectively. In antioxidant activity assay, the juice exhibited moderate DPPH and ABTS+ radical scavenging and ferric-reducing activities. The addition of 5% fruit juice extended the microbial shelf life of chiffon cake. The treated chiffon cake had a shelf-life of 7 days, compared to 3 days for the untreated control. These results support the possible use of Mao fruit juice as an antimicrobial agent and a natural food preservative.
Car-Following Dynamics, Characteristics, and Model Based on Interaction Potential Function
Authors: Qu Dayi , Zhao Zixu , Hu Chunyan , Wang Tao , Song Hui
Published: January 2022

To model the car-following behavior more accurately, we carried out the molecular similarity analysis between the vehicles on the road and the inert gas system, comparing vehicles with microscopic particles in long and narrow pipes. The complex car-following interaction behavior is simplified into a dynamic process of the follower car that is constantly seeking to maintain the required safety distance from the leading vehicle. Through mathematical derivation of the Lennard–Jones potential function suitable for thermodynamic analysis of inert gas systems, the influence of each variable on the potential energy is clarified, and the existing problems of the existing molecular car-following model are analyzed, referring to the general Lennard–Jones potential function to build the vehicle interaction potential function. Considering the impact of the road wall potential generated by the lane boundary, a car-following model based on Lennard–Jones interaction potential is presented. The simulation test results show that compared with the existing molecular car-following model and IDM model, the average absolute error and root mean square error of the vehicle acceleration results obtained by this model and the actual data are lower, which proves that the vehicle is based on the Lennard–Jones interaction potential. The vehicle-following model based on Lennard–Jones interaction potential has a better fitting effect on the real vehicle-following behavior.
Car-Following Model with Automatic Reaction Delay Estimation: An Attention-Based Ensemble Learning Methodology
Authors: Liao Lyuchao , Lin Zewei , Lin Jinmei , Hu Dongmei , Zou Fumin , Lai Shukun
Published: January 2022

Car-following behavior is a vital traffic phenomenon in the process of vehicle driving. For modeling the car-following behavior, it is crucial to capture the reaction delay for balancing with safety and comfort, but it is generally ignored in existing works. This work proposes a car-following model based on attention-based ensemble learning to automatically capture the reaction delay from driving data and better depict the traffic flow characteristics. The model integrates a data-driven model and a theory-driven model, and a weight computation method is proposed to combine the advantage of these two different models. In detail, an encoder-decoder model and attention mechanism are employed to capture the reaction delay from driving data. Extensive experiments show that the proposed model could balance safety with comfort and help avoid unsafe driving behavior.
Whole Body Vibration Exposure among the Tractor Operator during Soil Tillage Operation: An Evaluation using ISO 2631-5 Standard
Authors: Singh Amandeep , Samuel Siby , Singh Harwinder , Singh Jagmeet , Prakash Chander , Dhabi Yash Kumar
Published: January 2022

This study is aimed at investigating the effect of various tractor ride conditions on the lumbar spine during rotavator operation. The lumbar spinal response was assessed by determining static compressive dose, i.e., Sed (8). Raw acceleration data were measured on the seat pan and seat backrest to varying tractor velocity, tillage depth, and pulling force. The field experiments have been designed using Taguchi’s L9 orthogonal array and the entire data analyzed in signal-to-noise ratios terms. The mean acceleration responses were dominant along the vertical axis and exposure levels were found beyond the exposure action value, i.e., 0.5 m/s2 as per Directive 2002/44/EU. Mean Sed (8) exceeded the limits of ISO 2631-5 indicating the probability of adverse health effects. Tractor velocity and pulling force have a significant impact on Sed (8) with a 64.43% and 27.73% percentage contribution. The FFT dominant peaks have been found in the 0.8 to 3.7 Hz frequency range. Moreover, the exact frequency of the peaks is found to be dependent on the experimental circumstances. The depicted dominant frequencies found in the range of low frequencies could lead to musculoskeletal disorders since they coincide with the natural frequencies of various parts of the body, especially in the lumbar region.
A Multiple Sound Source Localization and Counting Method Based on the Kernel Density Estimator
Authors: Fang Yuzhuo , Zang Xian , Yang Juan , Zhou Hongcheng , Xu Zhiyong
Published: January 2022

An unambiguous signal processing algorithm when using a wide intermicrophone distance is proposed in this paper for simultaneously locating and counting multiple active sound sources. Based on the kernel density estimator, a multistage structure in the time-frequency domain is used to suppress the influence of spatial aliasing, then the pooled angular spectrum is combined with a peak search method having an updated cut-off threshold and a source merging module. Complete source localization and counting is realized through the combination of these two steps. Simulation results show that the proposed method has a more robust performance than the classic counterpart, especially in adverse environments with spatial aliasing, reverberation, and interference between different sound sources.
Tripartite Evolutionary Game Analysis of Trust Relationship between Enterprises in a Cloud Manufacturing Environment: A Service Composition Perspective
Authors: Wang Jing , Yang Bao , Zhai Lili
Published: January 2022

Due to the existence of limited rationality and information asymmetry, trust between enterprises in the cloud manufacturing environment is characterized by significant complexity. In this paper, to promote the formation of a better trust relationship between enterprises and to ensure the efficient service and stable operation of the manufacturing process to a greater extent, we take into account the subjective cognition of the game parties from the perspective of service combination, introduce the prospect theory, construct an evolutionary game model of “service demander‐service provider‐platform supervisor,” analyze the evolutionary stabilization strategy, and explore the influence of different factors on the interenterprise trust relationship in the cloud manufacturing environment through numerical simulation. The results show that enhancing the synergy between multiple service providers has a significant impact on improving trust between cloud manufacturing enterprises. The rewards and punishments of the cloud manufacturing platform are conducive to improving interenterprise trust. There exists a critical value dividing opportunistic behavior into explicit and implicit behaviors. When it is less than the critical value, opportunistic behavior is implicit and the service demander trusts the service provider and the transaction continues; when it is greater than the critical value, opportunistic behavior is explicit and the service demander no longer trusts until the service provider is fully trustworthy. The inhibitory effect of good transaction history on opportunistic behavior is evident. Finally, the reasons and effects of the above factors and the subjective perceptions of the game parties in cloud manufacturing are discussed, as well as their concrete manifestations in the CASICloud (China Aerospace Science&Industry Cloud) and relevant suggestions are put forward.
Study on Influencing Factors of Frailty in Elderly Patients with Type II Diabetes
Authors: Song Yingying , Lin Ziwei , Ding Miaomiao , Yuan Peipei , Li Qianqian , Zhai Hongli , Hu Feilong , Zhang Lingli , Wang Junmao
Published: January 2022

The purpose of this study was to analyze the influencing factors of frailty in elderly patients with type II diabetes. 332 elderly patients with type II diabetes admitted to our hospital from May 2018 to December 2019 were selected as the study subjects. The degree of frailty was evaluated by the Fried fragility phenotype scale, and the general information and the clinical data of patients were collected by inquiry and questionnaire survey. After that, all the data were analyzed by SPSS 20.0. Univariate analysis showed that there were significant differences in age, medication types, dietary habits, exercise tolerance, exercise capacity, body balance, coordination ability, urinary incontinence, anxiety, etc., in elderly patients with type II diabetes who suffered from different degrees of frailty (

P

 < 0.01). In addition, there were significant differences in the presence of coronary heart disease, heart failure, atrial fibrillation, pulmonary diseases, osteoarticular diseases, anemia, and other blood diseases of elderly patients with type II diabetes who suffered from different degrees of frailty (

P

 < 0.01). Multiple Logistic regression analyses indicated that weakened exercise tolerance, reduced exercise capacity, atrial fibrillation, anemia, and other blood diseases were the influencing factors of the frailty in elderly patients with type II diabetes. The degree of frailty in elderly patients with diabetes is affected by many factors, such as exercise tolerance, exercise capacity, atrial fibrillation, anemia, and other blood diseases; thus, reasonable intervention should be implemented for elderly patients with type II diabetes according to the influencing factors so as to effectively relieve frailty.
Diagnostic Value of Systemic Inflammatory Response Index for Catheter-Related Bloodstream Infection in Patients Undergoing Haemodialysis
Authors: Yang Jiajia , Wang Hongmei , Hua Qing , Wu Jian , Wang Ying
Published: January 2022

Objective. This study was aimed at investigating the diagnostic value of the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), C-reactive protein-to-albumin ratio (CAR), and systemic inflammatory response index (SIRI) for catheter-related bloodstream infection (CRBSI) in patients undergoing haemodialysis. Methods. A total of 296 patients undergoing haemodialysis with vascular access were selected and divided into the infected (58 patients) and uninfected (238 patients) groups. Their aetiological and general characteristics were retrospectively collected. The NLR, PLR, CAR, and SIRI were calculated. Results. The NLR, PLR, CAR, and SIRI values in the infected group were significantly higher than those in the uninfected group (

P
<
0.05

). After the anti-infective treatment, the NLR, PLR, CAR, and SIRI values in patients with CRBSI were significantly decreased (

P
<
0.05

). The NLR, CAR, and SIRI showed diagnostic efficacy in patients with CRBSI with cut-off values of 4.485 (

area
 
under
 
the
 
curve
 

AUC

=
0.827

,

95
%
confidence
 
interval
 

CI

=
0.768
–
0.887

), 0.975 (

AUC
=
0.836

,

95
%
CI
=
0.779
–
0.892

), and 3.390 (

AUC
=
0.947

,

95
%
CI
=
0.919
–
0.976

). The CAR and SIRI values in patients with gram-negative bacterial infection were significantly higher than those with gram-positive bacterial infection (

P
<
0.05

). The AUCs of CAR and SIRI were 0.693 (0.537–0.848) and 0.821 (0.700–0.942) in differentiating gram-negative and gram-positive bacterial infections, respectively. Conclusion. Our results showed SIRI as a novel and efficient indicator for the early diagnosis of CRBSI in patients undergoing haemodialysis.
[Retracted] Eco‐Friendly Synthesis of Multishaped Crystalline Silver Nanoparticles Using Hill Garlic Extract and Their Potential Application as an Antifungal Agent
Authors: Nallal V. Uma Maheshwari , Razia M. , Duru Ozlem Ates , Ramalingam G. , Chinnappan Sasikala , Chandrasekaran Murugesan , Gengan R. M. , Chung Woo Jin , Chang Soon Woong , Ravindran Balasubramani
Published: January 2022

Antimicrobial resistance is a global health challenge, and the large loads of biocides dumped into the environment augment the spread of antifungal resistance and environmental contamination. Therefore, eco‐friendly antifungal agents must be developed to combat antibiotic resistance and to reduce environmental contamination. In the present investigation, Allium sativum (Hill garlic‐Malai Poondu) extract was used as a green resource to achieve silver nanoparticle (AgNP) production. AgNPs were characterized by various spectral and microscopic analyses. In vitro free radical scavenging assays were instigated to determine the antioxidant capacity of the AgNPs, and the antifungal activity was assessed using Agar well‐diffusion assay again pathogenic fungal strains. The mean particle size of the AgNPs was calculated as 35.1 nm with face‐centered cubic (FCC) structure. AgNPs exhibited free radical scavenging activity against 2,2‐diphenyl‐1‐picrylhydrzyl (DPPH), 2,2‐azino‐bis (3‐etilbenzotiazolin)‐6‐sulfonic acid (ABTS), and hydrogen peroxide (H2O2) radicals. Scavenging of DPPH radicals by AgNPs was impressive, and an IC50 value of 6.3 ± 0.4 μg/ml was obtained in this assay. Among the tested Candida strains, the order of the least susceptibility on exposure to AgNPs synthesized using Hill garlic extract was as follows: C.glabrata ≤ C.tropicalis ≤ C.parapsilosis ≤ C.krusei ≤ C.albicans. The study highlights the synthesis of environment‐friendly nanoparticles using Hill garlic extract with enhanced antifungal properties.
Research on the Weight Removing Model and Control Method for the Unbalance Vector of Thin Disc Workpiece
Authors: Zhang Shihai , Zhu Yecheng , Zhang Zimiao
Published: January 2022

Aiming at the structuring characteristics of thin disc workpiece, we propose the weight removing model and control methods to reduce the mass unbalance vector. Based on the material removing and correcting principle for unbalance workpiece, the weight removing model of drilling and reaming hole way and internal and external arc milling is discussed. The iterative control method with variable weight removing rate is proposed to reduce the weight removing material of the first-time correction and improve the ultimate correcting accuracy. The online measuring and correcting feasibility for unbalance workpiece is verified by experimental way. The advantages of the proposed iterative control method are discussed by simulation analysis. The research results can be used for the online correction of the unbalance disc workpiece on the NC machine tools or automatic dynamic balancing machine.
Generative Adversarial Network-Based Short Sequence Machine Translation from Chinese to English
Authors: Ma Wenting , Yan Bing , Sun Lianyue
Published: January 2022

With the acceleration of economic globalization, the economic contact, information exchange, and financial integration between countries become more and more frequent. In this context, the communication between different languages is also closer, so accurate translation between languages is of great significance. However, existing methods give little thought to short sequence machine translation from Chinese to English. This paper designs a generative adversarial network to solve the above problem. First, a conditional sequence generating adversarial net is constructed, which includes two adversarial submodels: a generator and a discriminator. The generator is designed to generate sentences that are difficult to distinguish from human-translated sentences, and the discriminator is designed to distinguish the sentences generated by the generator from human-translated sentences. In addition, static sentence-level BLEU values will be used as reinforcement targets for the generator. During training, both dynamic discriminators and static BLEU targets are used to evaluate the generated sentences, and the evaluation results are fed back to the generator to guide the generator's learning. Finally, experimental results on English-Chinese translation dataset show that the translation effect is improved by more than 8% compared with the traditional neural machine translation model based on recurrent neural network (RNN) after the introduction of generative adversative network.
miR-138-5p Inhibits the Growth and Invasion of Glioma Cells by Regulating WEE1
Authors: Gong Jianwu , Tang Zhi , Yu Zhengtao , Deng Zhiyong , Liu Yan , Ren Nianjun , Wang Lei , He Zhengwen
Published: January 2022

Background. Accumulating evidence has demonstrated the role of differentially expressed miRNAs in glioma progression. Our previous bioinformatics analyses revealed a role of miR-138-5p in glioma. miR-138-5p was decreased in various tumors, and He et al. found that miR-138-5p had an inhibitory effect on glioma cells in 2021. However, the role of miR-138-5p in the development of glioma and the underlying mechanism is unknown. In this study, we explored whether miR-138-5p affects the biology of glioma by regulating WEE1 expression. Methods. miR-138-5p and WEE1 G2 checkpoint kinase (WEE1) RNA and protein expression levels in glioma tissues were detected with qRT-PCR and western blotting, respectively. The effects of miR-138-5p and WEE1 on glioma cell migration and invasion were investigated using Transwell assays. CCK-8 assay was used to measure the effects of miR-138-5p and WEE1 on glioma cell proliferation. The mortality of glioma cells transfected with miR-138-5p and WEE1 was measured with flow cytometry. The relationship between miR-138-5p and WEE1 was explored using a luciferase reporter analysis. Results. Functional studies indicated that overexpression of miR-138-5p suppressed cell proliferation, migration, and invasion and promoted death in glioma cell lines. WEE1 was identified as a target of miR-138-5p, and overexpression of miR-138-5p significantly suppressed the levels of WEE1. Moreover, reintroduction of WEE1 partially abrogated miR-138-5p-induced suppression of motility and invasion in glioma cells. Conclusion. The low expression of miR-138-5p in glioma suggests a tumor suppressor role for this miRNA. miR-138-5p suppresses glioma progression by regulating WEE1. These data provide new insights into the molecular mechanism of glioma.
Effect of Lycium barbarum Polysaccharide on Decreasing Serum Amyloid A3 Expression through Inhibiting NF-κB Activation in a Mouse Model of Diabetic Nephropathy
Authors: Wan Fengqi , Ma Fulin , Wu Jiaxin , Qiao Xinyu , Chen Minxue , Li Wenjian , Ma Liang
Published: January 2022

Lycium barbarum polysaccharide (LBP) as one of the main bioactive constituents of the fruit of Lycium barbarum L. (LBL.) has many pharmacological activities, but its antihyperglycemic activity is not fully understood yet. This study investigated the hypoglycemic and renal protective effects of LBP on high-fat diet/streptozotocin- (HFD/STZ-) induced diabetic nephropathy (DN) in mice. Blood glucose was assessed before and after 8-week administration of LBP, and the homeostasis model assessment-insulin resistance (HOMA-IR) index was calculated for evaluating the antidiabetic effect of LBP. Additionally, serum creatinine (sCr), blood urea nitrogen (BUN), and urine microalbumin were tested to evaluate the renal function. HE and PAS stainings were performed to evaluate the morphology and injury of the kidney. The results showed that LBP significantly reduces the glucose level and ameliorates the insulin resistance of diabetic mice. Importantly, LBP improves renal function by lowering the levels of sCr, BUN, and microalbumin in diabetic mice and relieves the injury in the renal glomeruli and tubules of the DN mice. Furthermore, LBP attenuates renal inflammation as evidenced by downregulating the mRNA levels of TNFα, IL1 β, IL6, and SAA3 in the renal cortex, as well as reducing the elevated circulating level and protein depositions of SAA3 in the kidney. In addition, our western blot results showed that NF-κB p65 nuclear translocation and the degradation of inhibitory κB-α (IκBα) occurred during the progress of inflammation, and such activated signaling was restrained by LBP. In conclusion, our findings suggest that LBP is a potential antidiabetic agent, which ameliorates the inflammation in DN through inhibiting NF-κB activation.
Financial Data Center Configuration Management System Based on Random Forest Algorithm and Few-Shot Learning
Authors: Li Xinxin , Wang Lina
Published: January 2022

To form a unified configuration and information management platform, FCCMS (financial center configuration management system) will integrate and sort information based on various configuration data and relationships as well as integrate processes and permissions. However, the most serious issue that data centers are currently facing is how to effectively manage these infrastructures. For various infrastructures, the data center currently uses a decentralized operation and maintenance management model. When an infrastructure fails due to inexperienced configuration management, this mode is not conducive to quickly locating and resolving the problem. A detection method of RFCO (random forest algorithm based on clustering optimization) is proposed, and an appropriate tree is selected from RF to integrate, so as to achieve the best effect. In this paper, the target matching algorithm based on FSL (few-shot learning) is deeply studied, and the target detection model is applied to the target matching and positioning task by using the ML method. The performance of the algorithm is tested by experiments on relevant datasets to verify the effectiveness of the algorithm in various scenarios.
The TCM Prescription Yi-Fei-Jie-Du-Tang Inhibit Invasive Migration and EMT of Lung Cancer Cells by Activating Autophagy
Authors: Wang Shanshan , Wang Zaichuan , Wu Yinqiu , Hou Chao , Dai Xiaojun , Wang Qingyin , Wu Yongjian , Qian Chao , Zhang Xiaochun
Published: January 2022

Yi-Fei-Jie-Du-Tang (YFJDT) is a traditional Chinese medicine formulation. Our previous studies have demonstrated that YFJDT can be used to treat non-small-cell lung cancer (NSCLC), but its protective effect against NSCLC and its mechanisms remain unclear. In the present study, we evaluated the protective effects and potential mechanisms of YFJDT on a tumor-bearing mouse lung cancer model and A549 cell model. Tumor-bearing mice and A549 cells were treated with YFJDT, tumors were measured during the experiment, and tumor tissues and cell supernatants were collected at the end of the experiment to assess the levels of autophagy and epithelial-mesenchymal transition (EMT)-related proteins. The results showed that YFJDT treatment reduced tumor volume and mass, increased the expression of the autophagy marker LC3, and inhibited EMT-related proteins compared with the model group. Cell survival was reduced in the YFJDT-treated groups compared with the model group, and YFJDT also reduced the migration and invasion ability of A549 cells in a dose-dependent manner. Western blotting detected that YFJDT also upregulated FAT4 in the tumor tissue and A549 cells and downregulated the expression of vimentin. Meanwhile, apoptosis in both tissues and cells was greatly increased with treatment of YFJDT. We further interfered with FAT4 expression in cells and found that the inhibitory effect of YFJDT on EMT was reversed, indicating that YFJDT affects EMT by regulating FAT4 expression. Taken together, results of this study suggested that the inhibitory effect of YFJDT on EMT in lung cancer tumors is through upregulating FAT4, promoting autophagy, and thus inhibiting EMT in cancer cells.
Incidence and Predictors of Pulmonary Tuberculosis among Children Who Received Antiretroviral Therapy (ART), Northwest Ethiopia: A Multicenter Historical Cohorts Study 2009–2019
Authors: Kebede Fassikaw , Tarekegn Habtamu , Molla Mulugeta , Jara Dube , Abate Abebe
Published: January 2022

The human immune deficiency virus (HIV) is the strongest risk factor for endogenous reactivation of pulmonary tuberculosis (PTB) through target reduction of CD4, T-lymphocytes, and cellular immune function. Almost one-third of deaths among people living with HIV are attributed to tuberculosis. Despite this evidence, in Ethiopia, information is scarce and meager regarding PTB incidence after ART initiated for seropositive children. Methods. Facility-based multicenter historical cohort was conducted among 721 seropositive children after initiating ART from January 1, 2009, to December 31, 2019. Data from the records of children were extracted using a standardized checklist. The collected data were entered using Epi-Data version 4.2 and exported to STATA (SE) R-14 version statistical soft wares for further analysis. Bivariable and multivariable Cox regression analyses were conducted to identify predictors of PTB incidence. Results. Seven hundred twenty-one (N = 721) seropositive children were included with a mean (±SD) age of 118.4 ± 38.24 months. During the follow-up periods, 63 (15.2%) participants developed new cases of TB; majority (61/63, 96.8%) of them were PTB. The overall incidence rate and the median (±IQR) time of PTB reported were determined as 5.86 per 100 child years (95% CI: 4.58, 7.5) and 17.8 (±11) months, respectively. At baseline, children being severely stunted (AHR = 2.9 : 95% CI, 1.2–7.8,

P
=
0.03

), with Hgb ≤10 mg/dl (AHR = 4.0; 95% CI, 2.1–8.1,

P
=
0.001

), and not given isoniazid and cotrimoxazole preventive therapy (AHR = 2.4; 95% CI: 1.2; 5.1,

P
=
0.001

) (AHR = 2.5; 95% CI, 1.4–4.7,

P
=
0.021

) were significantly associated with PTB incidence. Conclusion. A high incidence rate of PTB was observed in our study as compared with the previous finding in Ethiopia. Cases at baseline not taking IPT and CPT, being severely stunted, and having low hemoglobin (≤10 mg/dl) levels were found to be at higher risk of developing PTB.