bluuebunny/crossref_metadata_2025 huggingface dataset:
Visualização de dados para extração de conhecimento: um estudo de caso
Authors: Matsuba Daniel Sadao , Mattedi Adriana Prest
Published: May 2021

Introdução: O rápido crescimento no volume de dados coletados nos últimos anos está tornando o processo de análise e extração de conhecimento cada vez mais complexo. Organizações têm tido dificuldades em agregar essas grandes quantidades de dados em análises úteis para dar suporte a suas decisões. Objetivo: Avaliar a implantação de ferramentas de data mining visual em uma startup de seguros (insurtech) para smartphones. Método:  Foram desenvolvidos painéis dinâmicos usando o software Tableau. Os dados de alimentação do sistema foram divididos dois grupos (“Medidas” e “Dimensões”) para cada tema de análise escolhido. Também foi feita uma pesquisa de usabilidade junto aos usuários dos painéis. Resultados: A agregação de diversas subtelas e informações em um mesmo painel foi importante para os usuários visualizarem novos padrões. Conclusão: A introdução das novas ferramentas de descoberta de conhecimento fez com que os usuários passassem a apresentar um conhecimento mais profundo sobre o tema e fazerem melhores análises sobre os padrões.
Olga Tokarczuk: Listening
Authors: Paloff Benjamin
Published: May 2021

This article argues that the loose plotting and wide-ranging digressions that characterize Olga Tokarczuk’s fiction, and that many readers have noted as a challenge to their own expectations, are integral features of the discourse model that most of her work employs, namely, a telling in which the narrator is not entirely certain why he or she is speaking in the first place. By adapting the discourse model of the psychotherapeutic encounter, Tokarczuk places the reader in the position of the empathic, yet disinterested listener who strives to absorb another’s speech without imposing preconceived agendas, intentions, or narrative designs. Relieved of the narrative burden of having to convince or inform the text’s audience, the speakers in Tokarczuk’s fiction are thus free to make their own leaps and associations. By the same token, the reader is left to make an ever-evolving sense out of the accumulation of often disjointed details. This dynamic shifts the traditional occasion of storytelling to emphasize not the narrative information conveyed by the telling, but rather the conversational intimacy that arises within the dialogic space between speaker and listener. With reference to Tokarczuk’s fiction and her own reflections on fiction-making, the article concludes that this intimacy is at the core of Tokarczuk’s authorial project, which simulates in the textual space what we experience whenever we strive to listen empathetically to others in the real world.
From “Poland’s Genius” to the World as “a living, single entity”: World, Literature, and Writer’s Duty in Lectures of Polish Laureates of the Nobel Prize in Literature (1905–2019)
Authors: Zechenter Katarzyna
Published: May 2021

Reading the Nobel Prize Lectures delivered by Polish Nobel laureates in literature from 1905 to 2019 as one mutually influencing narrative (the so-called “collective narrative”) clearly suggests the changing direction of how Polish writers perceive the world, Poland, and the social obligations of literature towards humanity. The early focus on Poland’s loss of independence and the injustice of fate (Henryk Sienkiewicz) gave way to seeing the entire world as a unity (Wisława Szymborska, Czesław Miłosz, Olga Tokarczuk). The mutually exclusive participation in life and being a detached observer. although seen as an insolvable contradiction (Miłosz) is acknowledged. but now with the urgent need for an engagement with the world’s fate (Szymborska, Tokarczuk). Literature is seen as a vehicle for painful memory and the acknowledgment of the injustices of the twentieth century (Miłosz), a tool of analysis of the human and non-human condition in general (Szymborska), and as a way of telling stories that represents the only remaining path to universal human understanding and bond (Tokarczuk). For Tokarczuk, “the tender narrator” represents the powerful connection necessary for searching for meaning and interhuman communication in the face of an approaching danger of the destruction of the world by humans.
Two-Year Postoperative Validation of Patient-Reported Outcomes Measurement Information System Physical Function After Lumbar Decompression
Authors: Cha Elliot D. K. , Lynch Conor P. , Parrish James M. , Jenkins Nathaniel W. , Geoghegan Cara E. , Jadczak Caroline N. , Mohan Shruthi , Singh Kern
Published: May 2021

Introduction:

Physical function evaluated by Patient-Reported Outcomes Measurement Information System (PROMIS PF) instrument has been validated through the short-term postsurgical period in spine surgery patients. Evidence for long-term efficacy of PROMIS PF is lacking in lumbar decompression (LD) patients. The objective of this study was to evaluate correlations between PROMIS PF and legacy patient-reported outcome measures for patients undergoing LD.

Methods:

Consecutive primary or revision, single-level or multilevel LD surgeries were retrospectively reviewed from May 2015 to September 2017. Patients lacking preoperative or 2-year PROMIS PF scores were excluded. Demographics, baseline pathology, and perioperative characteristics were collected, and descriptive statistics performed. Visual Analogue Scale (VAS) back and leg, Oswestry Disability Index (ODI), 12-Item Short Form (SF-12) Physical Composite Score (PCS), and PROMIS PF were collected at preoperative and postoperative timepoints and evaluated for improvement from baseline values. Correlations between PROMIS PF and VAS back, VAS leg, SF-12 PCS, and ODI were calculated and categorized according to the strength of relationship.

Results:

Ninety-two patients were included in this study with 58.7% of LDs performed at the single level. All patient-reported outcome measures demonstrated significant improvement from baseline values at all assessment timepoints (all P < 0.001). Apart from preoperative VAS back and VAS leg, PROMIS PF demonstrated a significant and strong correlation with VAS back, VAS leg, ODI, and SF-12 PCS at all timepoints (all P < 0.001).

Conclusion:

PROMIS PF demonstrated a strong correlation with pain, disability, and PF outcome measures throughout the postoperative period out to 2 years after LD. Our study provides longitudinal evidence that the PROMIS PF instrument is a valid measure for PF for patients undergoing LD.
Incidence and Management of Articular Impaction in Geriatric Olecranon Fractures
Authors: Wadhwa Harsh , Goodnough L. Henry , Finlay Andrea K. , DeBaun Malcolm R. , Campbell Sean T. , Hecht Garin , Lucas Justin F. , Bishop Julius A. , Gardner Michael J.
Published: May 2021

Introduction:

Olecranon fractures are common in the elderly. Articular impaction is encountered occasionally, but the incidence and outcomes after treatment of this injury pattern have not been well characterized.

Methods:

We evaluated a cohort of geriatric olecranon fractures to determine the incidence of articular impaction and describe a technique for open reduction and internal fixation.

Results:

Of the 63 patients in our series, 31 had associated intraarticular impaction (49.2%). Patients with articular impaction did not have significantly different rates of postoperative complications (11/31, 35.5% versus 10/31, 32.3%; P = 1.00) or revision surgery (10/31, 32.3% versus 8/31, 25.8%; P = 0.780) compared with those without articular impaction.

Conclusion:

Articular impaction is a common feature of geriatric olecranon fractures. Surgeons must maintain a high index of suspicion and have a surgical plan in place for managing this component of the injury.
Management of Recalcitrant Cubital Tunnel Syndrome
Authors: Lauder Alexander , Chen Christopher , Bolson Rajshri M. , Leversedge Fraser J.
Published: May 2021

Cubital tunnel syndrome is a common upper extremity compressive neuropathy. Recalcitrant cubital tunnel syndrome poses diagnostic and treatment challenges. Potential etiologies of persistent or recurrent symptoms after surgical treatment include an inaccurate preoperative diagnosis, incomplete nerve decompression, iatrogenic injury, postsurgical perineural adhesions, irreversible nerve pathology, or conditions associated with secondary nerve compression. Confirmation of recalcitrant ulnar nerve pathology relies on a thorough history to consider symptoms and chronology, careful examination to quantify nerve function and to assess for focal nerve provocation, and objective testing to highlight a possible nerve lesion such as ultrasonography and electrodiagnostic testing. Conservative treatment may provide symptomatic relief; however, surgical management such as revision neuroplasty, neurolysis, nerve reconstruction, and/or anterior transposition may be indicated. Optimizing the biology of the local nerve environment is critical. No surgical treatment procedure has shown superiority over another; however, individualized treatment is emphasized to improve symptoms and maximize nerve recovery potential.
Impact of Advanced Age on Postoperative Outcomes Following Transforaminal Lumbar Interbody Fusion
Authors: Mohan Shruthi , Cha Elliot D. K. , Lynch Conor P. , Geoghegan Cara E. , Jadczak Caroline N. , Singh Kern
Published: May 2021

Introduction:

Age 65 years or older is considered a risk factor for worse outcomes after transforaminal lumbar interbody fusion (TLIF). However, few studies have differentiated this cohort from younger patients. This study compares postoperative outcomes among patients 65 years or older of age with a younger cohort after minimally invasive (MIS) TLIF.

Methods:

A database was reviewed for adults undergoing primary, elective, single-level MIS TLIF procedures for degenerative pathology from 2008 to 2019. Outcomes included visual analogue scale (VAS) for back and leg, Oswestry Disability Index (ODI), Short Form 12-Item physical component score (SF-12 PCS), and Patient-Reported Outcome Measurement Information System physical function. Outcomes were collected preoperatively and at 6 weeks, 12 weeks, 6 months, and 1 year postoperatively. Patients were categorized as ≥75 years, 65 to 74 years, or <65 years of age. Propensity score matching was performed, and outcome improvement and minimum clinically important difference (MCID) achievement were evaluated by group. MCID achievement was calculated using previously established values.

Results:

Our cohort included 51 patients aged younger than 65 years, 47 patients aged 65 to 74 years, and 16 patients aged 75 years or older. No significant perioperative differences or complications existed between groups. The 65- to 74-year group improved in VAS back, leg, and ODI from 6 weeks to 1 year (all P < 0.001) and SF-12 PCS at 12 weeks to 1 year (all P < 0.005). VAS back, ODI, and SF-12 PCS differed between groups preoperatively (P < 0.050), and VAS back and ODI varied at 6 weeks (P < 0.01). VAS leg differed between groups at 12 weeks and SF-12 PCS at 1 year (both P < 0.050). MCID achievement was similar between groups except for VAS leg at 6 weeks (P = 0.038) and 12 weeks (P = 0.023).

Conclusion:

Patients 65 years or older of age markedly improved from baseline, similarly to younger patients. Postoperative outcome scores and MCID achievement demonstrated differences between groups at intermittent timepoints. With appropriate selection criteria, patient age may not act as a notable risk factor for successful MIS TLIF procedures.
Gender and Socioeconomic Factors Affect Adolescent Patient and Guardian Preferences in Sports Medicine Physician Characteristics and Medical Decision Making
Authors: Beck Jennifer J. , West Nicole , Jackson Nicholas , Willimon S. Clifton , Busch Michael T. , Christino Melissa A.
Published: May 2021

Introduction:

Diversity has increased within youth sports. It is unknown whether these demographic or socioeconomic factors affect adolescent patients' and their guardians' preferences of sports medicine physicians and involvement in medial decision making. Demographic and socioeconomic factors may affect adolescent patient and guardian preferences for sports medicine physicians.

Methods:

Patients, age 10 to 18 years, and their guardians presenting to two sports medicine offices were asked to complete matched, anonymous surveys assessing their preferences for medical decision making, sports medicine physician gender, and personality characteristics. Analysis of demographic and socioeconomic effects on preferences was completed.

Results:

Matched survey responses were collected from 353 patients and 325 corresponding guardians. Patient average age was 14.6 years (SD 2.1), with 43% female. Guardian average age was 43.4 years (SD 8.3), with 79% female. For both patients and guardians, the highest valued physician characteristic was being a good listener. Overall, 21% of patients and 17% of guardians reported a physician gender preference that matched the gender of the patient. Among all female patients, 32% preferred a female physician. Among all male patients, 12% preferred a male physician (P < 0.001). Ninety-two percent of patients reported wanting to be involved, and 93% of guardians thought that their child should be involved in the decision-making process. Hispanic, non-White, non-English speaking, government or no insurance, or less than college level of education patients and guardians reported a significantly greater importance of the physician independently determining the treatment plan (P < 0.001).

Conclusions:

Demographic and socioeconomic factors do affect adolescent patient and guardian preferences for sports medicine physicians. Young patients have a desire to be included in the medical decision-making process. Female adolescent patients may have a same-gender preference for their sports medicine physician.

Study Design:

This is a prospective, cohort study.
Sports College Students and Entrepreneurship: An Investigation into Entrepreneurship Tendencies
Authors: ATILGAN Davut , TÜKEL Yalçın
Published: May 2021

The purpose of this research is to examine the relationship between the entrepreneurship tendencies and self-efficacy of sports college students and whether there is a difference in terms of some demographic variables. The research is a quantitative study based on a relational survey model. The sample of the study consists of 495 participants who continue their education as active students in sports colleges affiliated to the Directorates of National Education in Konya and Kahramanmaraş in Turkey. The data of the research were analysed using a statistical software program. The arithmetic mean and standard deviation values were determined for the data analysis, and the t-test and One-Way Analysis of Variance (ANOVA) tests were used to determine the differentiation of the scores obtained for the variables. In addition, a correlation analysis was used to determine the relationship between variables, and a regression analysis was used to test whether the independent variables predict the dependent variable or not. As a result of the research, it was observed that the entrepreneurship and self-efficacy mean scores of the participants were at a moderate level and that the scores of the participants regarding entrepreneurship and self-efficacy levels differed significantly in terms of the variables of the province, the gender, and the grade level. It was also concluded that as the entrepreneurship perception of the students of sports college increases, their self-efficacy increases and the sub-dimensions “self-confidence, innovativeness, control focus, risk-taking and desire to accomplish” are significant predictors of students’ general self-efficacy while the dimension of “making difference and determination” is not a significant predictor of their general self-efficacy.
Perception Driven From Farmers’ Socio-economic Characteristics Towards Tackling Climate Change
Authors: Tshikororo Mpho , Thaba Katlego , Nefale Tshimangadzo Ashely , Tshikororo Mashudu
Published: May 2021

Climate change is part of us and we are unlikely to avoid its impact. Impacts of climate change are severely felt within the agricultural sector, the division that strives to ensure food and nutrition security and contribute towards sustainable development in many of the developing countries. The only way farmers can survive in the face of climate change is through adaptation, a phenomenon that needs collaborative efforts. One of the critical driving factors of climate change adaptation is farmers’ perception towards tackling it, the focus of this paper. The main objective of this paper was to assess farmers’ perception towards tackling climate change. The population of the study was emerging farmers drawn from five districts of the Limpopo province, South Africa. The study used a two-stage cluster sampling technique to select a sample size of 206 emerging farmers. The dependent variable of the study was farmers’ perception about tackling climate change while the explanatory variables consisted of their socio-economic characteristics such as age, gender, farming experience and level of education. Discriminant Analysis was used to draw comparison between groups of farmers who perceived that climate change can be tackled and those who believed it cannot be. The results showed that socio-economic characteristics such as formal education, agricultural education, age group, farming experience and off-farm occupation significantly contributed towards farmers’ perception regarding tackling of climate change. Therefore, the study recommended that stakeholders should facilitate linkage of farmers with varied sources of support.
The COVID 19 Pandemic: College Adolescents’ Perception on School Reopening in Nigeria
Authors: Chinawa Awoere T. , Chinawa Josephat M , Ossai Edmund N , Aronu Ann E , Onukwuli Vivian O
Published: May 2021

BACKGROUND: Several colleges were closed in the wake of the COVID-19 pandemic. However, it is not clear if school closure has curbed the incidence of the infection.

OBJECTIVES: This study aimed to determine the perception of adolescent college students on school reopening and associated factors.

METHODOLOGY: This was a school-based cross-sectional study. A two-stage sampling technique was used to select five hundred adolescent college students from six secondary schools in the Enugu metropolis, Nigeria. Data were analysed with IBM Statistical Package for Social Sciences (SPSS) statistical software version 25.

RESULTS: The mean age of the students was 15.1±1.7 years and the majority, 56.4% were females. A higher proportion of the respondents, 78.0% were willing to return to school. For those not willing to return to school, the major reason was the preference for homestay until the pandemic is over, 57.3%. The majority of the students, 67.6% had their learning improved during the pandemic. More than half of the students, 65.0% had online classes during the pandemic. Predictors of willingness to return to school amidst the COVID-19 pandemic included being a male student, (AOR=0.304, 95%CI: 0.189-0.489), and being from a family of high socio-economic class, (AOR=0.363, 95%CI: 0.154- 0.855).

CONCLUSION: Closure of schools should be revisited, with enforcement of all preventive measures. Alternative methods for education such as e-learning seem to create a divide between the rich and the poor. It is therefore pertinent to develop a bridging plan to fill the gap created by this divide.
Lymphovenous Anastomoses Between Thoracic Duct and Azygos Vein in a Human Cadaver: A Case Report
Authors: Koutsouflianiotis Konstantinos N. , Paraskevas George , Piagkou Maria , Noussios George , Natsis Konstantinos
Published: May 2021

Objective. The study adds valuable information regarding lymphovenous communications between the thoracic duct and the azygos vein, which are very rarely discovered during anatomical dissections and very few cases have been mentioned worldwide. A detailed description of our findings and a brief review of the relevant literature are also provided.

Case report. In the current study, two sizeable obliquely directed lymphovenous anastomoses between the thoracic duct and the azygos vein at the midportion of the mediastinum are described in the same cadaver.

Conclusion. The existence of such anastomoses in humans, as well in animals, is a scientific issue under debate. Cases of rapid cancer spread could be potentially explained by the likely presence of the abovementioned communications.
The Influence of Gender on the Cortical Width of the Lower Border of the Mandible and the Mandibular Cortical Index
Authors: Kamber-Ćesir Alma , Dardagan Đonlagić Amela , Ajanović Muhamed , Strujić Porović Sanela , Gavranović Alma , Kazazić Lejla , Berhamović Lejla , Berhamović Emir
Published: May 2021

Objective. To evaluate the influence of gender on the mental index (MI) and  the mandibular cortical index (MCI).

Methods. In this study, there were 120 subjects (43 male and 77 female subjects), who had undergone a dental panoramic radiograph examination for the needs of diagnosis and future treatment planning. MI and MCI were determined by orthopantomograph.

Results. There was a statistically significant difference in MI dependent on gender. Male patients demonstrated significantly higher values for MI than female patients (right: t=4.127; P=0.0001, left: t=3.110; P=0.002). No statistically significant difference was observed for MCI dependent on gender (right: χ²=2.36 P=0.308, left: χ²=3.85 P=0.146).

Conclusion. MI is affected by gender, but MCI is not.
The Veil of Obscuration: Additional Radiographic Sign of Posterior Shoulder Dislocation
Authors: Hirai Gimber Lana , Taljanovic Mihra S. , Rockov Zachary A. , Krupinski Elizabeth A. , Chadaz Tyson S. , Rogers Lee F.
Published: May 2021

Objective. To describe a new radiographic sign, “veil of obscuration”, associated with posterior glenohumeral joint (shoulder) dislocations and determine its incidence and validity compared to other known classic radiographic signs.

Methods. Four-year retrospective study identified 30 acute posterior shoulder dislocation patients. Radiographs reviewed in consensus by 2 musculoskeletal radiologists for the “veil of obscuration”, seen on AP shoulder radiographs and representing a comminuted fracture of the lesser tuberosity projecting over the humeral head or glenohumeral joint. Incidence of this radiographic sign of posterior glenohumeral joint dislocation in addition to other previously described classic radiographic signs, and association with other fractures, surgery, and mechanism of injury were evaluated. Continuous data was analysed with student t-test and categorical data with Chi-Square test.

Results. There were 20 right and 10 left posterior shoulder dislocations. Majority of injuries resulted from vehicle crash (44%). In most cases, reverse Hill-Sachs lesion (83%) and fixed internal rotation of the humeral head (76%) were present, followed by trough line (43%) and “veil of obscuration” (40%). Trough line was seen in significantly more major trauma and vehicle crashes (78% and 46%; P=0.015), while “veil of obscuration” was seen in more seizures (86%; P=0.037) and in all surgical patients.  No significant difference in presence of other classic radiographic signs in regards to surgery.

Conclusion. The newly described radiographic sign of posterior shoulder dislocations named the “veil of obscuration” has comparable incidence as other classic radiographic signs and may be useful in the recognition and diagnosis of these injuries.
Evaluation of Physical Parameters of Novel Licorice Varnish Versus Fluoride and Combination Varnish: An In-Vitro Study
Authors: Sankeshwari Roopali , Ankola Anil , Bhat Kishore , Bolmal Udaya , Rao Malleswara
Published: May 2021

Objectives. The aim of this study was to evaluate the physical properties of locally prepared Licorice varnish (LV), commercially available  Fluoride varnish (FV) and a Combination of both Varnishes (CV).

Material and Methods. LV was prepared using authenticated licorice roots. Commercially available FV (Bifluorid 12) was used as a positive control and CV was prepared in six different concentrations of both varnishes. Conventional antibacterial activity assessment, employing disc diffusion and broth dilution methods, was inconclusive. Therefore a novel assessment method was used, whereby the varnish was directly added to a mixture of Brain Heart Infusion broth with  Streptococcus mutans and incubated. Physical parameters such as pH, rate of evaporation, viscosity, film forming ability, and cost incurred for preparation were assessed and compared.

Results. FV, LV and CV (except the combination of LV 80% + FV 20%) showed antibacterial activity against Streptococcus mutans. All three varnishes formed films on the tooth surface as confirmed by Scanning Electron Microscopy. Mean pH was in the range of 4-4.5, viscosity 48-52 centipoise (cP), rate of evaporation was 150-160 seconds. They were comparable to each other in the physical parameters tested, except for the shelf life of LV.

Conclusion. All three varnishes showed antibacterial activity against Streptococcus mutans which was established using an innovative method of antibacterial activity assessment. LV was most economical of all but had a shorter shelf life. The results of this study need to be evaluated through an in vivo study.
Relapsing Tumefactive Demyelination: A Case Report
Authors: Omerhodžić Ibrahim , Džurlić Almir , Lisica Dino , Mahmutbegović Nevena , Nikšić Maida , Bilalović Nurija , Suljić Enra
Published: May 2021

Objective. We present a case of relapsing tumefactive demyelination in a young female patient, that posed a real diagnostic challenge, with a heterogeneous clinical picture, atypical for multiple sclerosis (MS) presentation, and neuroradiological manifestations with a high suspicion of neoplastic diseases.

Case Report. An 18-year old female patient presented to our Neurosurgical Out-patients’ Clinic with symptoms atypical for multiple sclerosis, unremarkable neurological deficit, one tumefactive lesion on MRI, followed by relapse and another two lesions within a period of six months. We decided to perform biopsy of the tumefactive lesion with compressive effect. Serological and clinical data were negative for MS, and the patient did not respond well to corticosteroid therapy. Fresh frozen tumor tissue aroused a strong suspicion of gemistocytic astrocytoma, so total resection was done, but the definitive pathohistological examination confirmed tumefactive demyelination.

Conclusion. For clinicians, it is important to consider demyelinating disease in the differential diagnosis of a tumorlike lesion of the central nervous system, in order to avoid invasive and potentially harmful diagnostic procedures, especially in younger patients.
A Rare Branching Pattern of a Middle Mesenteric Artery Supplying the Head of the Pancreas and the Transverse Colon
Authors: Venieratos Dionysios , Tsoucalas Gregory , Panagouli Eleni
Published: May 2021

Objective. The appearance of a middle mesenteric artery is a rare branching variation, with an incidence lower than 0.1%. Our case reports such an anatomical artery pattern which was discovered in a male Caucasian cadaver during routine educational dissection.  This alternation is seldom encountered and may trouble diagnostic and surgical interventions.

Case Report. The case of a Middle Mesenteric Artery is described, as a vessel originating from the Abdominal Aorta 3.3 cm below the origin of the Superior Mesenteric and 3.8 cm above the origin of the Inferior Mesenteric Artery. The middle mesenteric artery, directed upwards, gives two branches for supplying blood to the head of the pancreas. We first mention the thinner branch, corresponding to the posterior one of the inferior pancreaticoduodenal artery, and second the thicker branch corresponding to the anterior branch of the Inferior Pancreaticoduodenal Artery. The main artery continues its course between the two sheets of the mesocolon to supply the transverse colon, thus substituting the normal colic artery.

Conclusion. The occurrence of a Middle Mesenteric Artery constitutes a very rare anatomic variation. We present, to our knowledge, the first case described where the Middle Mesenteric Artery provides blood to the pancreas.
Multiple Abnormalities in the Skull of a Prostitute. An Autopsy Report (1900)
Authors: Licata Marta , Larentis Omar , Tesi Chiara , Iorio Silvia
Published: May 2021

Objective. The study presents and comments on the publication of an autopsy report.

Case Report. In 1900 De Blasio published an article entitled “Multiple abnormalities in a prostitute’s skull” in the “Journal of Psychiatry, Criminal Anthropology and related sciences”. In this work De Blasio related anomalies at the cranial level to the presence of mental pathologies. The skull belonged to a 24-year-old prostitute who died of syphilitic hepatitis. In his article, De Blasio described the life of the woman, after which he gave a macroscopic description of the skull. De Blasio believed that the subject’s amoral behavior was caused by the anomalous shape of the subject’s skull.

Conclusion. From the study, it is evident that the school of criminal anthropology influenced De Blasio’s autopsy medical practice, and it is interesting to note the interpretation of anthropologists of the time who tried to describe the link between physical and behavioral anomalies.
Multiple Myeloma Genomics – A Concise Review
Authors: Castaneda Omar , Baz Rachid
Published: May 2021

The aim of this review is to summarize the current knowledge of genomic information in multiple myeloma. Multiple myeloma is a genetically complex plasma cell neoplasm that evolves from pre-malignant stages following genomic evolution leading to the proliferation of malignant plasma cells and the production of monoclonal immunoglobulin. The outcomes of patients with myeloma have dramatically improved over the past decade with the introduction of novel agents. Nevertheless, the disease is considered incurable and displays considerable heterogeneity in clinical presentation, course and survival. This heterogeneity can often be traced to cytogenetic abnormalities in the malignant clone. Accordingly, a large body of literature has examined the impact of genomics on myeloma and risk stratification based on cytogenetics has been adopted. In this review, we will focus on the cytogenetics of multiple myeloma and the prognostic significance as well as possible predictive implications. We will briefly review the existing methodologies relevant to myeloma but explore in greater depth the more novel molecular tools as applied to this disease.

Conclusion. The field of genomics in multiple myeloma is rapidly evolving however more translational research is needed to accurately use genomic data as a tool of precision medicine.
Precision Medicine in Oncology Pharmacy Practice
Authors: Saadeh Claire , Bright David , Rustem Danielle
Published: May 2021

The objective of this review is to provide an overview of the components, process and resources available to apply precision medicine strategies to drug therapy in cancer medicine, with an emphasis on oncology pharmacy practice. Precision medicine initiatives in oncology take into account individual variability in genes, environment and lifestyle factors. Genomic assays of patient tumors is now the standard of care in oncology and recommendations for targeted drug therapies are often formulated by interprofessional teams. Pharmacogenomics (PGx) is a component of precision medicine based on polymorphisms that impact medication selection and/or dosing. Several oncolytic agents used in the treatment of cancer and supportive care have pharmacogenomic-based dosing recommendations to minimize potential toxicities. Several resources are reviewed here to guide treatment options in oncology as they relate to somatic mutations and PGx. Examples include: OncoKB is a precision oncology knowledge base that offers evidence-based information for somatic mutations. The Clinical Pharmacogenetics Implementation Consortium provides PGx-based guidelines for several oncolytic therapies used to treat cancer and for supportive care. Pharmacists can be integral members of the interprofessional team in many practicesettings in precision medicine. Involvement can include membership in molecular tumor boards, PGx dosing services and provide patient education.

Conclusion. Precision medicine is a rapidly evolving field in oncology that requires an interprofessional approach of drug therapy experts.
The Isolation of Human Glioblastoma Cells: An Optimised Protocol
Authors: Velnar Tomaz , Maver Uros , Bosnjak Roman , Gradisnik Lidija
Published: May 2021

Objective. The aim of this study was to establish an optimised protocol for glioblastoma (GBM) cell isolation from brain resection samples, with a high yield and low risk for contamination.

Methods. Human GBM cells can be obtained following cranial tumour operations. In sterile conditions, the fragments of viable tissue removed during surgery were collected. The tissue was cut and mechanically coarsely decomposed. The sediment was harvested after centrifugation, the cells were seeded in suspension, and supplemented with a special medium (Advanced DMEM) containing high level nutrients and antibiotics.

Results. In an appropriate environment, the isolated cells retained viability and proliferated quickly. Attachments were observed after ten hours, and proliferation after two days. The time to full confluence was about one week. The cells were stable. Under standard culture conditions, cell proliferation and cluster formation were observed. Cell viability was 95%.

Conclusion. The protocol described for isolation is easy, quick and affordable, leading to stable GBM cells. The isolation technique provides sufficient quantities of isolated cells that may be used as an important new tool for in vitro research. The availability of this system will permit the study of cell properties, biochemical aspects, and provides the potential of therapeutic candidates for pathological disorders in a well-controlled environment.
Longterm Antiepileptic Therapy and Bone Health: Implications for Patients with Brain Tumors
Authors: Mehičević Admir , Mahmutbegović Nevena , Omerhodžić Ibrahim , Mehmedika Suljić Enra
Published: May 2021

Objective. The objective of our study was to investigate the effects of carbamazepine (CBZ) and lamotrigine (LTG) treatment on bone metabolism in epileptic patients.

Patients and Methods. A cross-sectional study was performed on normal controls (N=30) and 100 patients with symptomatic epilepsy caused by a primary brain tumor, divided into two groups according to the treatment: LTG monotherapy group (N=50) and CBZ monotherapy group (N=50). For each participant serum levels of 25-OHD and osteocalcin (OCLN) were measured, and bone mineral density (BMD) was evaluated by the dual-energy X-ray absorptiometry method.

Results. There was no statistically significant difference in the average values of vitamin D in serum between the CBZ and LTG groups (Vitamin D CBZ 17.03±}12.86 vs. Vitamin D LTG 17.97±}9.15; F=0.171, P=0.680). There was no statistically significant difference in the average values of OCLN between the CBZ and LTG groups (OCLN CBZ 26.06±}10.87 vs. OCLN LTG 27.87±}28.45; F=0.171, P=0.674). The BMD value was lower in both groups using antiepileptic agents compared to the controls, but when comparing the CBZ group to the LTG group, a statistically significant difference was only observed for the Z score (T-score CBZ: 0.08±} 1.38 vs. T-score LTG: 0.37±} 1.02; F=1.495, P=0.224; Z score CBZ: -0.05±}1.17 vs. Z. Score CBZ: 0.38±}0.96; F=4.069, P=0.046) (Table 3).
Conclusion. The choice of antiepileptic agents for treating seizures in patients with brain tumors should be carefully evaluated in relation to their impact on bone health. These patients could benefit from supplementation and regular measurement of biochemical markers of bone turnover and BMD.
O Estado da Técnica em Leitura de Imagens para Cidadãos com Deficiência Visual: um Mapeamento Sistemático em Documentos de Patente
Authors: Marques João Marcelo dos Santos , Nunes Maria Augusta Silveira Netto , Machado Rita Pinheiro , Ferreira Simone Bacellar Leal
Published: May 2021

Com o advento da revolução industrial, diversas inovações tecnológicas surgiram, visando solucionar alguns problemas do dia a dia de uma sociedade. Este artigo tem como objetivo realizar um mapeamento sistemático do estado da técnica em documentos de patentes, para identificar as tecnologias desenvolvidas para a leitura de descrições de imagens destinadas aos cidadãos com deficiência visual. Durante o mapeamento foram localizados 491 estudos primários que passaram por filtros (critérios de inclusão, exclusão e questões de qualidade), nos quais pôde-se extrair 46 documentos de patentes relevantes. Desses 46 documentos, observou-se que ainda há pouca participação da comunidade acadêmica no patenteamento de suas invenções e que 6% desses documentos podem estar localizados em bibliotecas de periódicos.
Apoiando Alinhamento Estratégico em Organizações Usando Contratos Eletrônicos Estendidos com BLA
Authors: Florio Lilian , Salles Guilherme B. M. , Fantinato Marcelo
Published: May 2021

Por meio de contratos eletrônicos é possível subcontratar de organizações parceiras serviços eletrônicos, a serem compostos em processos de negócio, e definir SLA (Service Level Agreement), o que não garante o alinhamento estratégico entre as áreas de TI e as áreas de negócio de cada organização envolvida. Este artigo apresenta uma extensão de uma abordagem de estabelecimento de contratos eletrônicos incluindo o tratamento de BLA (Business Level Agreement), usado para alinhar metas e objetivos de uma organização, sendo possível garantir que atividades de responsabilidade de TI não causem impactos negativos para o negócio.
O estado da arte em Recuperaçãoo de modelos tridimensionais por conteúdo através de uma Revisão Sistemática
Authors: Bergamasco Leila C. Carneiro , Nunes Fátima L. S.
Published: May 2021

O avanço da tecnologia possibilita a construção de Sistemas de Informação mais complexos. Uma das abordagens que tem sido desenvolvida nesse sentido e o uso de ambientes tridimensionais. Devido ao grande vo-lume de dados nas bases de imagens é necessária a implementção de métodos eficientes para efetuar a busca desses modelos. Uma das tecnicas existentes é a recuperação baseada por conteúdo, que possui diversos algoritmos para extração de características e usa funções de similaridade para comparar objetos diferentes. Este artigo apresenta resultados de uma Revisao Sistemática realizada sobre este tema, a fim de analisar as técnicas, extratores, funções de similaridade e banco de dados usados.
Metodo Adaptativo de Programação da Produção Apoiado por um Sistema de Medição de Desempenho e Melhoria Contínua
Authors: Belan Helder Carlo , Palma Jandira Guenka
Published: May 2021

Este trabalho propõe um método de programaçãoo da produçãoo que se adapte ao cenário produtivo de cada indústria. Denominado de MAP-Prod o método deve incorporar características das abordagens reativa e proativa, onde o ciclo de adaptação ser a caracterizado por ações de melhoria encontradas através da coleta de informações e análise de indicadores em um sistema de medição de desempenho. Estas ações serão acompanhadas por um sistema de melhoria contínua para diagnosticar a eficacia das mesmas. Uma simulação entao é realizada com dados reais de uma indústria para averiguar os resultados que podem ser obtidos com o método.
VisPublica: uma proposta para aprimorar a transparência de dados públicos
Authors: Ribeiro Fernanda C. , Ferreira Thiago P. , De Paula Melise M. V. , Chaves Miriam , Rodrigues Sergio A. , De Souza Jano M. , Franzosi Ednylton M. , Oliveira Luiz F. S.
Published: May 2021

Atualmente, no contexto governamental, a transparência das informações representa um dos grandes desafios. Este cenário pode ser analisado a partir de diferentes perspectivas. No aspecto tecnológico, o grande volume de dados e a complexidade das relações entre esses dados exigem abordagens específicas não somente para a disponibilização dos dados, mas para a fácil interpretação das informações pelos cidadãos. Neste artigo, será descrita uma aplicação desenvolvida no contexto do projeto VisPublica cujo objetivo é analisar técnicas de Visualização de Informações que facilitem a interpretação de dados públicos.
Relations between IT Architecture and Information Quality in DW and BI Environments
Authors: Schmidt Samuel Otero , Prado Edmir P. Vasques , Takaoka Hiroo
Published: May 2021

The organizations are investing more in information technology to collect, store and process vast amounts of information. Generally this information has no standard and repeated data, which hinders the decision making process. The cause of the difficulties is related to Information Quality (IQ) that has technical characteristics related to the architecture used in Data Warehouse (DW) and Business Intelligence (BI) environments. Based on the existing literature and insights from the author a research model was created to identify the relations between components of DW/BI architecture and IQ dimensions. We used the case study as research method. This research makes contributions to better understand IT architecture for DW/BI.
Sistema Móvel de Apoio a Decisão Médica Aplicado ao Diagnóstico de Asma – InteliMED
Authors: De Morais Dyego C. Sales , De Morais Bruno C. Sales , De Menezes Júnior Júlio Venâncio , De Gusmão Cristine M. Gomes
Published: May 2021

A estrutura de saúde pública possui essencialmente serviços descentralizados, o que viabiliza a utilização de dispositivos móveis. Ainda assim percebe-se que há uma lacuna quanto ao uso desses meios em saúde básica. Além de se fazerem necessárias ferramentas de apoio à tomada de decisão baseada em evidências coletadas. Neste contexto, este artigo apresenta a experiência da construção de um sistema móvel de suporte à decisão para apoio ao diagnóstico médico utilizando inteligência computacional. A discussão aborda aplicação simultânea de diferentes metodologias ágeis, aplicabilidade de dispositivos móveis em saúde e utilização de inteligência artificial em sistemas de apoio a decisão médica.
An Investigation on the Use of Navigation Devices in Smart Transportation Systems
Authors: Bazzan Ana L. C. , Azzi Guilherme G.
Published: May 2021

In large urban areas, until recently, people used to choose a route having in mind the general, high-level mental map of the urban traffic network. With the dissemination of the use of navigation devices such as GPS, all roads may now be part of a path. Therefore two questions arise, that are related to the performance of the traffic network as a whole, and to the effects of the use of these navigation devices on travelers that usually only do short trips in their own neighborhoods. Our preliminary results show that the average overall travel times indeed decrease with the use of GPS. However, travelers who used to avoid arterial roads are strongly penalized.
Lessons learned from one decade of developing agent-based tools for traffic modeling, simulation, and control: how to make cities smarter
Authors: Bazzan Ana L. C.
Published: May 2021

While there is no definitive agenda for making cities smarter in terms of mobility, intuition says that information is key. However, contrarily to a more technical view, information should not only be consumed by the users, but also produced by them. This is already happening (smart-phones, social networks) but is far from being exploited by technical systems related to transportation. In this paper I discuss some of the issues related to more human-centered transportation system. It is argued that users of this system are somehow influencing it with their increasing coupled behaviors. Thus, there is a real opportunity for changing the paradigm in order to take advantage of the collective intelligence.
Determinantes da posse de telefonia móvel no Brasil: o acesso à internet importa?
Authors: Nishijima Marislei , Fagundes Jorge , Lima Marcos A. M.
Published: May 2021

Desde 2008 o acesso à internet passou a ser obrigatório na telefonia móvel brasileira. Este artigo investiga quais são os determinantes da posse de telefonia móvel no Brasil a partir dos microdados da PNAD referente aos anos de 2008 e 2009. Os resultados, obtidos a partir de modelos logit, mostram que o acesso à internet aumenta a probabilidade de posse de telefonia móvel em 19%.
Classificação Contínua de Documentos com Vocabulários Temáticos Dinâmicos para a Desambiguação de Termos
Authors: Santos Adriano A. , Schiel Ulrich
Published: May 2021

Obter resultados precisos que reflitam o desejo dos usuários é um dos maiores desafios dos Sistemas de Recuperação de Informações. Uma prévia classificação temática dos documentos permite uma desambiguação prévia dos termos e garante maior precisão na recuperação de documentos. No entanto, as técnicas tradicionais de classificação de documentos utilizam bases de conhecimento estáticas e universais, que não representam a dinâmica da evolução do conhecimento linguístico e, muito menos, a dependência espaço-temporal do sentido das palavras. Com base nisso, a proposta deste trabalho é apresentar uma técnica que considera esta dinâmica por meio de um Thesaurus sensível ao contexto.
Uma Arquitetura para o Registro de Dados de Proveniência em Operações de Caracterização Geológica
Authors: Lima Gefersom , Viterbo José , Boscarioli Clodis , Marassi Edmundo
Published: May 2021

Na prospecção de reservatórios de poços de petróleo, a caracterização geológica é uma fase importante para a construção de modelos que representam os elementos do sistema petrolífero. O registro das informações de proveniência relativas aos passos intermediários deste processo e o conjunto de dados utilizados nas operações realizadas, permite que a qualidade da caracterização resultante seja completamente avaliada e que o processo seja reproduzido sob outras circunstâncias. Este trabalho propõe uma arquitetura que suporta a coleta e recuperação de dados de proveniência em aplicações de caracterização geológica, e apresenta uma ferramenta protótipo implementada como extensão do Sigeo3, um arcabouço de desenvolvimento de software geocientífico utilizada pela Petrobras.
A Case Study on Legacy Information Systems Migration: A Fault Tolerant Approach
Authors: Herrera Rafael de Paula , Felinto Alan Salvany
Published: May 2021

Legacy Information Systems play key-roles on organizations development and growth. However, they can be considered as risky factor to operations chain whether they do not meet the demanding or become acting as single point of failures. In this work, we propose a migration model which is able to handle systems that depend on Relational Databases and its changes were driven through the use of a distributed middleware. We also pose how this approach was successfully applied while migrating a Legacy Information System to a Cloud Computing based infra-structure, adding fault-tolerance to its architecture as a competitive advantage, enabling the related services to be clustered and then horizontal scaled on demand. All major concerns on how the whole solution and its aggregated tools were conceived are discussed in high-level details, so them can be solely reproduced and integrated to another systems in order to achieve the same goals or improve its level of quality assurance.
Eficiência Técnica de Aeroportos: uma abordagem focada na infraestrutura aeroportuária - Lado Ar
Authors: Crespo Antonio Márcio Ferreira
Published: May 2021

As sedes de grandes eventos esportivos se tornam centros turísticos de notória atratividade, implicando grande incremento de demanda por deslocamentos aéreos. Neste contexto, o presente trabalho objetivou analisar de que forma a configuração da infraestrutura aeroportuária condicionou o desempenho de dezessete aeroportos que apoiarão as sedes da Copa 2014. Os dados foram processados segundo a abordagem de análise multivariável denominada Análise de Envoltória de Dados. Os resultados obtidos indicam que alguns aeroportos podem ter ganhos de capacidade apenas com a otimização de procedimentos operacionais; outros, contudo, carecem de intervenções na infraestrutura para obter tal incremento.