bluuebunny/crossref_metadata_2025 huggingface dataset:
Incidences of Rocuronium Use during Anesthetic Induction in Adult Patients Undergoing Orthopedic Surgery Using Supraglottic Airway Devices: A Retrospective Analysis
Authors: Bae Yu-Kyung , Na Hyo-Seok , Hwang Jung-Won , Lim Young-Jin , Do Sang-Hwan
Published: September 2024

Background/Objectives: Neuromuscular blocking agents (NMBAs) are not usually necessary during the induction of general anesthesia in patients using supraglottic airway (SGA) devices. In this study, we assessed the incidences of rocuronium use in adult patients undergoing general anesthesia using SGA devices. Methods: From September 2022 to August 2023, the medical records of adult patients (≥19 years) who underwent orthopedic surgery using SGA devices were retrospectively investigated. The incidences of rocuronium use during anesthetic induction were analyzed according to the anesthetic induction drug. The association of rocuronium use during anesthesia was analyzed in terms of demographic (age, sex, height, and weight), surgical (surgical time), and anesthetic factors (premedication, anesthetic agent, anesthetic time). Results: In total, 321 patients were enrolled. The incidence rate of rocuronium use during anesthetic induction was 28.3%. In the subgroup analysis, patients receiving total intravenous anesthesia (TIVA) with propofol (PPF) and remifentanil showed a markedly lower incidence (14.4%) than the other anesthetic groups. Premedication or short anesthetic duration was associated with lower incidences of rocuronium use. Demographic and other anesthetic factors did not seem to affect the incidences of rocuronium use during anesthesia. Conclusions: The incidence of rocuronium use during anesthetic induction with SGA devices was significantly lower with the PPF-TIVA compared to that using remimazolam-TIVA or inhalational anesthesia. Premedication with midazolam and shorter operation times were associated with a significantly lower incidence of rocuronium use.
Changes in Plasma Concentration of Free Proteinogenic and Non-Proteinogenic Amino Acids in High-Performance Sprinters over a 6-Month Training Cycle
Authors: Kusy Krzysztof , Matysiak Jan , Zarębska Ewa Anna , Klupczyńska-Gabryszak Agnieszka , Ciekot-Sołtysiak Monika , Plewa Szymon , Kokot Zenon J. , Dereziński Paweł , Zieliński Jacek
Published: September 2024

Background/Objectives: Free amino acids substantially contribute to energy metabolism. Also, their profile may identify (over)training status and effectiveness. The long-term effects of speed-power training on plasma free amino acid (PFAA) profiles are not known. We aimed to observe variations in PFAA levels in high-performance sprinters in a six-month training cycle. Methods: Ten male athletes (24.6 ± 3.3 years) were examined during four training phases: transition (1 month), general preparation (2 months), specific preparation (1 month), and pre-competition/competition (2 months). Venous blood was collected at rest, after exhaustive exercise, and recovery. Forty-two PFAAs were analyzed by the LC-ESI-MS/MS method. Results: Significant decreases in resting concentrations were observed between the transition and competition phases for glutamine (762 ± 117 vs. 623 ± 53 μmol∙L−1; p < 0.001, η2 = 0.47) and histidine (89 ± 15 vs. 75 ± 10 μmol∙L−1; p = 0.010, η2 = 0.27), whereas β-alanine (30 ± 7 vs. 41 ± 9 μmol∙L−1; p = 0.024, η2 = 016) and sarcosine (3.6 ± 0.4 vs. 4.8 ± 0.6 μmol∙L−1; p = 0.006, η2 = 0.188) levels increased. Between the specific and competition phases, significant decreases in the resting levels of 1-methylhistidine (22.1 ± 19.4 vs. 9.6 ± 8.8 μmol∙L−1; p = 0.14, η2 = 0.19), 3-methylhistidine (7.1 ± 1.5 vs. 6.5 ± 1.6 μmol∙L−1; p = 0.009, η2 = 0.18), citrulline (40 ± 10 vs. 29 ± 4 μmol∙L−1; p = 0.05, η2 = 0.29), and ornithine (74 ± 15 vs. 56 ± 10 μmol∙L−1; p = 0.015, η2 = 185) were noticed. Also, for β-alanine and sarcosine, the pattern of response to exercise strongly changed between the training phases. Blood ammonia levels at exhaustion decreased between the transition and competition phases (32 ± 4 vs. 23 ± 5 μmol∙L−1; p < 0.001, η2 = 0.67), while lactate, the phenylalanine–tyrosine ratio, the glutamine–glutamate ratio, hematological parameters, and cardiorespiratory indices remained at similar levels. Conclusions: Speed-power training seems to affect PFAAs involved in skeletal muscle metabolic pathways responsible for neutralizing toxic ammonia (glutamine, arginine, citrulline, ornithine), attenuating the deleterious effects of H+ ions (histidine, β-alanine), and reducing exercise-induced protein breakdown (1- and 3-methylhistidine). Our findings suggest that sprint-oriented training supports metabolic pathways that are responsible for the removal of harmful metabolites produced during exercise.
Does Applying Morpholine to Saliva-Contaminated Acrylic Resin Improve the Repair Bond Strength?
Authors: Klaisiri Awiruth , Krajangta Nantawan , Assawarattanaphan Kasidit , Sriperm Jaratchom , Prawatvatchara Wisarut , Thamrongananskul Niyom , Sriamporn Tool
Published: September 2024

The current study evaluates the effect of morpholine on saliva-contaminated acrylic resin repaired with light-cured resin composites. Sixty rods of self-curing acrylic resin were fabricated and assigned into four groups of fifteen specimens and surface-treated with saliva, phosphoric acid (PH), morpholine (MR), liquid MMA monomer, and a universal adhesive agent (UA, Singlebond Universal) based on the following techniques: group 1, saliva; group 2, saliva + PH + MMA + UA; group 3, saliva + MMA + UA; and group 4, saliva + MR + MMA + UA. An Ultradent model was placed at the center of the specimen, and then the resin composite was pressed and light-cured for 20 s. A mechanical testing device was used to evaluate the samples’ shear bond strength (SBS) scores. The debonded specimen areas were inspected under a stereomicroscope to identify their failure mechanisms. The data were assessed by employing the one-way ANOVA approach, and the significance level (p < 0.05) was established with Tukey’s test. The greatest SBS scores for group 2 (30.46 ± 2.26 MPa) and group 4 (32.10 ± 2.72 MPa) did not differ statistically significantly from one another. The lowest SBS recorded for group 1 was 1.38 ± 0.87 MPa. All of the fractured samples in group 1 had an adhesive failure profile. Groups 2 and 4 had the greatest percentages of cohesive failures. This study concluded that applying phosphoric acid and morpholine to sandblasted self-curing acrylic resin contaminated with saliva before MMA and universal adhesive agents are applied is the most efficient protocol for stimulating SBS when it is repaired with light-cured resin composites.
Carbon Nanotube–Carbon Nanocoil Hybrid Film Decorated by Amorphous Silicon as Anodes for Lithium-Ion Batteries
Authors: Chen Huan , Wang Chen , Fan Zeng , Cheng Chuanhui , Hao Liang , Pan Lujun
Published: September 2024

Silicon (Si) as the anode material for lithium-ion batteries (LIBs) has attracted much attention due to its high theoretical specific capacity (4200 mAh/g). However, the specific capacity and cycle stability of the LIBs are reduced due to the pulverization caused by the expansion of Si coated on Cu (copper) foil during cycles. In order to solve this problem, researchers have used an ultra-thin Si deposition layer as the electrode, which improves cyclic stability and obtains high initial coulomb efficiency of LIBs. However, suitable substrate selection is crucial to fabricate an ultrathin Si deposition layer electrode with excellent performance, and a substrate with a three-dimensional porous structure is desirable to ensure the deposition of an ultrathin Si layer on the whole surface of the substrate. In this paper, the Si thin layer has been deposited on a binder-free hybrid film of carbon nanotubes (CNTs) and carbon nanocoils (CNCs) by magnetron sputtering. Compared with densely packed CNT film and flat Cu foil, the loose and porous film provides a large surface area and space for Si deposition, and Si can be deposited not only on the surface but also in the interior part of the film. The film provides a large number of channels for the diffusion and transmission of Li+, resulting in the rapid diffusion rate of Li+, which improves the effective lithium storage utilization of Si. Furthermore, the CNC itself is super elastic, and film provides an elastic skeleton for the Si deposition layer, which eases its volume expansion during charge and discharge processes. Electrochemical tests have showed that the Si/CNT–CNC film electrode has excellent performance as anode for LIBs. After 200 cycles, the Si/CNT–CNC film electrode still had possessed a specific capacity of 2500 mAh/g, a capacity retention of 92.8% and a coulomb efficiency of 99%. This paper provides an effective way to fabricate high performance Si-nanocarbon composite electrodes for LIBs.
A Method for Estimating the Distribution of Trachinotus ovatus in Marine Cages Based on Omnidirectional Scanning Sonar
Authors: Hu Yu , Hu Jiazhen , Sun Pengqi , Zhu Guohao , Sun Jialong , Tao Qiyou , Yuan Taiping , Li Gen , Pang Guoliang , Huang Xiaohua
Published: September 2024

In order to accurately estimate the distribution of Trachinotus ovatus in marine cages, a novel method was developed using omnidirectional scanning sonar and deep-learning techniques. This method involved differentiating water layers and clustering data layer by layer to achieve precise location estimation. The approach comprised two main components: fish identification and fish clustering. Firstly, omnidirectional scanning sonar was employed to perform spiral detection within marine cages, capturing fish image data. These images were then labeled to construct a training dataset for an enhanced CS-YOLOv8s model. After training, the CS-YOLOv8s model was used to identify and locate fish within the images. Secondly, the cages were divided into water layers with depth intervals of 40 cm. The identification coordinate data for each water layer were clustered using the DBSCAN method to generate location coordinates for the fish in each layer. Finally, the coordinate data from all water layers were consolidated to determine the overall distribution of fish within the cage. This method was shown, through multiple experimental results, to effectively estimate the distribution of Trachinotus ovatus in marine cages, closely matching the distributions detected manually.
Gradient Boosted Trees and Denoising Autoencoder to Correct Numerical Wave Forecasts
Authors: Yanchin Ivan , Guedes Soares C.
Published: September 2024

This paper is dedicated to correcting the WAM/ICON numerical wave model predictions by reducing the residue between the model’s predictions and the actual buoy observations. The two parameters used in this paper are significant wave height and wind speed. The paper proposes two machine learning models to solve this task. Both models are multioutput models and correct the significant wave height and wind speed simultaneously. The first machine learning model is based on gradient boosted trees, which is trained to predict the residue between the model’s forecasts and the actual buoy observations using the other parameters predicted by the numerical model as inputs. This paper demonstrates that this model can significantly reduce errors for all used geographical locations. This paper also uses SHapley Additive exPlanation values to investigate the influence that the numerically predicted wave parameters have when the machine learning model predicts the residue. To design the second model, it is assumed that the residue can be modelled as noise added to the actual values. Therefore, this paper proposes to use the denoising autoencoder to remove this noise from the numerical model’s prediction. The results demonstrate that denoising autoencoders can remove the noise for the wind speed parameter, but their performance is poor for the significant wave height. This paper provides some explanations as to why this may happen.
Hydrodynamic Analysis of Different Formation Configurations of Catamaran in Regular Head Waves
Authors: Zhang Zhifan , Jiang Bo , Wang Longkan , Wei Shengren , Li Tao , Zhang Guiyong , Zong Zhi
Published: September 2024

When undertaking long-distance missions at sea, vessels aim to achieve an extended operational range through drag reduction and energy efficiency, while enhanced wave resilience also provides substantial benefits. In this work, the Delft-372 catamaran is utilized to investigate the feasibility of drag reduction and roll mitigation for catamaran formation sailing in waves, analyzing the effects of three different formation configurations and varying spacings. The overset grid method was employed to simulate vessel motions, while the Volume of Fluid (VOF) method captured the free surface. First, the numerical results of the catamaran’s resistance, pitch, and heave motion amplitudes under different wave conditions were compared with experimental data to verify the accuracy of the CFD numerical method, and a grid convergence analysis was performed. Next, numerical models of the Delft-372 catamaran were constructed in parallel, tandem, and lateral formations under wave conditions. The results of the single-ship simulation were employed as a benchmark to analyze the impact of different formation configurations and varying lateral and longitudinal spacings on the resistance, pitch, and heave motions of the catamarans. The study also examined the effects of wave interference between vessels and the combined influence of external waves on individual and overall hydrodynamic performance. Results indicated that the tandem formation outperformed the parallel and lateral formations, with optimal performance observed at the longitudinal distance of 1 LPP. Generally, during navigation, the follower catamaran should ideally be positioned in the trough of the stern wave of the leader catamaran.
Plasma Inflammatory Proteome Profile in a Cohort of Patients with Recurrent Vulvovaginal Candidiasis in Kenya
Authors: Rosati Diletta , Ricaño Ponce Isis , Omosa-Manyonyi Gloria S. , Bruno Mariolina , Kamau Nelly W. , Jaeger Martin , Kumar Vinod , Netea Mihai G. , van der Ven Andre J. A. M. , ten Oever Jaap
Published: September 2024

Vulvovaginal candidiasis (VVC) affects up to 75% of women at least once during their lifetime, and up to 8% of women suffer from frequent recurrent episodes of VVC (RVVC). A lack of a protective host response underlies vaginal Candida infections, while a dysregulated hyperinflammatory response may drive RVVC. This study aimed to investigate the systemic inflammatory protein profile in women with RVVC in an African population, considering the potential influence of hormonal contraceptive use on systemic inflammation. Using multiplex Proximity Extension Assay technology, we measured 92 circulatory inflammatory proteins in plasma samples from 158 RVVC patients and 92 asymptomatic women (controls). Hormonal contraceptive use was not found to have a statistically significant correlation with a systemic inflammatory protein profile in either RVVC patients or the asymptomatic women. RVVC women had lower circulating Fibroblast Growth Factor 21 (FGF-21) concentrations compared with healthy controls (adjusted p value = 0.028). Reduced concentrations of FGF-21 may be linked to the immune pathology observed in RVVC cases through IL-1β. This study may help to identify new biomarkers for the diagnosis and future development of novel immunomodulatory treatments for RVVC.
Assessing the Effects of a Diet of BPA Analogue-Exposed Microalgae in the Clam Ruditapes philippinarum
Authors: Fabrello Jacopo , Dalla Fontana Michela , Gaiani Noemi , Ciscato Maria , Roverso Marco , Bogialli Sara , Matozzo Valerio
Published: September 2024

In our previous study, we demonstrated that the microalgae Phaeodactylum tricornutum can bioaccumulate bisphenol A analogues. Since this microalgae species is part of the diet of marine filter-feeding organisms, such as bivalves, in this study we tested the hypothesis that a diet based on exposed microalgae can exert negative effects on the clam Ruditapes philippinarum. Microalgae were exposed for 7 days to 300 ng/L of bisphenol AF (BPAF), bisphenol F (BPF), and bisphenol S (BPS), alone or as a mixture (MIX), to allow bioaccumulation. Microalgae were then supplied as food to bivalves. After 7 and 14 days of diet, the effects of exposed microalgae were evaluated on a battery of biomarkers measured in haemolymph/haemocytes, gills and digestive glands of clams. In addition, bioaccumulation of the three bisphenols was investigated in clams by UHPLC-HRMS. The results obtained demonstrated that total haemocyte count (THC) increased in clams following ingestion for 7 days of BPAF- and BPF-exposed microalgae, while BPS-exposed microalgae significantly reduced THC after 14 days of diet. MIX- and BPS-exposed microalgae increased haemocyte proliferation. The diet of exposed microalgae affected acid and alkaline phosphatase activity in clams, with an opposite response between haemolymph and haemocytes. Regarding antioxidants, an increase in catalase activity was observed in clams after ingestion of BPA analogue-exposed microalgae. The results also demonstrated marked oxidative stress in gills, the first tissue playing an important role in the feeding process. Oxidative damage was recorded in both the gills and digestive glands of clams fed BPA analogue-exposed microalgae. Alterations in epigenetic-involved enzyme activity were also found, demonstrating for the first time that BPA analogue-exposed food can alter epigenetic mechanisms in marine invertebrates. No bioaccumulation of BPA analogues was detected in clam soft tissues. Overall, this study demonstrated that a diet of BPA analogue-exposed microalgae can induce significant alterations of some important biological responses of R. philippinarum. To our knowledge, this is the first study demonstrating the effects of ingestion of BPA analogue-exposed microalgae in the clam R. philippinarum, suggesting a potential ecotoxicological risk for the marine food chain, at least at the first levels.
Surgical Technique for Complementing Robotic-Assisted Total Knee Arthroplasty in Middle-Aged Patients with Rigid Knee Bones
Authors: Baek Ji-Hoon , Lee Su Chan , Ryu Suengryol , Lee Dong Nyoung , Kim Taehyeon , Ahn Hye Sun , Nam Chang Hyun
Published: September 2024

This study reports 12 cases of inaccurate bone cutting from a single-surgeon series of 509 consecutively performed robotic-assisted total knee arthroplasty (TKA) for 1 year. In addition, a complementary technique with the combined benefits of robotic-assisted and manual techniques that address this issue is described. From June 2020 to May 2021, a consecutive series of 509 TKAs was performed on 338 patients using a posterior-stabilized total knee prosthesis with a robotic-assisted system at our hospital. The surgical records were reviewed to identify the causative bone locations and bone re-cutting events correlated with improper trial instrument positioning. The re-cutting rate was 2.4% (12/509). All re-cutting attempts occurred because of improper cutting of the femoral posterior chamfer. Re-cutting was attempted mostly on middle-aged male patients. This complementary technique can facilitate manual bone cutting while retaining the advantages of robotic surgery during robotic-assisted TKA. Additionally, the combined technique of manual bone cutting and robotic-assisted surgery can be a useful alternative for middle-aged male patients with rigid knee bones.
Bankruptcy Prediction for Restaurant Firms: A Comparative Analysis of Multiple Discriminant Analysis and Logistic Regression
Authors: Huo Yang , Chan Leo H. , Miller Doug
Published: September 2024

In this paper, we used data from publicly traded restaurant firms between 2000 and 2019 to test the effectiveness of multiple discriminant analysis (MDA) and logistic regression (logit) in predicting the probability of bankruptcy in the restaurant industry. We constructed various financial ratios extracted from the financial information and analyzed them to determine the optimal models. Our results show that liquid ratios (particularly the quick ratio), operating cash flow, and working capital emerge as the most crucial indicators of potential bankruptcy filings for restaurant firms. The results also show that the logit model performs better within the sample. However, both models exhibit similar predictive capacities with out-of-sample data.
Evaluating Cultivated Reserved Land Resources in a Highly Urbanized Region of China: A Case Study in Haishu District, Ningbo City
Authors: Wang Xiaoyi , Chai Lifu , Zeng Sidong , Su Jianbin , Ye Bin , Lü Haishen , Chen Changqing , Gong Junfu , Liu Mingwen , Wang Xiaoqing , Zhou Shiliang
Published: September 2024

Cultivated reserved land resources are pivotal for achieving food security and sustainable agricultural development. However, existing research on these resources often grapples with issues such as the lack of current data and underutilization of available data. This study focuses on Haishu District in Ningbo City of China, an economically developed area, and uses the third national land survey data to identify potential agricultural and construction lands suitable for conversion to cultivation. Through the application of the limiting factor method and the Analytic Hierarchy Process (AHP), the results indicate that the potentials of reserved cultivated land and the reclamation potential of construction land in Haishu District are estimated at 503.07 and 1527.50 ha, respectively. These lands are primarily rated as generally suitable and marginally suitable for agriculture, suggesting a moderate overall quality of reserved cultivated resources. This study emphasizes the practice of surveying reserved cultivated land, to boost effective land management and strategic development.
Overview for Exploring the Multisensory Landscape
Authors: Chamberlain Brent , Smardon Richard
Published: September 2024

Land use change has had a fundamental impact on the livelihoods of people throughout the world [...]
Civic Engagement in Urban Planning and Development
Authors: Horelli Liisa , Wallin Sirkku
Published: September 2024

The scientific literature has revealed that there is often a discrepancy between urban planning initiatives and the actual development of cities. Urban development is a complex process strongly affected by the self-organisation of citizens and entrepreneurs, who produce services and events, create new public places, and shape urban regeneration through everyday practices. However, the actors of self-organised urban development are rarely met in participatory urban planning practices. The gap raises the research problem of how to recognise and facilitate civic engagement in urban development. The authors of this article have been investigating the ontology and methodology of urban planning and development over the past two decades, culminating in the framework of expanded urban planning. The article aims to present multiple approaches to civic engagement in urban planning and development, based on an updated longitudinal study conducted in a Helsinki neighbourhood. The authors argue that urban planning should be updated with expanded urban planning (EP), which extends the focus of civic engagement from public participation to self-organisation and everyday life practices.
Unveiling the Role of Climate and Environmental Dynamics in Shaping Forest Fire Patterns in Northern Zagros, Iran
Authors: Beygi Heidarlou Hadi , Gholamzadeh Bazarbash Melina , Borz Stelian Alexandru
Published: September 2024

Wildfires present a major global environmental issue, exacerbated by climate change. The Iranian Northern Zagros Forests, characterized by a Mediterranean climate, are particularly vulnerable to fires during hot, dry summers. This study investigates the impact of climate change on forest fires in these forests from 2006 to 2023. The analysis revealed significant year-to-year fluctuations, with notable fire occurrence in years 2007, 2010, 2021, and 2023. The largest burned area occurred in 2021, covering 2655.66 ha, while 2006 had the smallest burned area of 175.27 ha. Climate variables such as temperature, humidity, precipitation, wind speed, heat waves, and solar radiation were assessed for their effects on fire behavior. Strong correlations were found between higher average temperatures and larger burned areas, as well as between heat waves and increased fire frequency. Additionally, higher wind speeds were linked to larger burned areas, suggesting that increased wind speeds may enhance fire spread. Multiple linear regression models demonstrated high predictive accuracy, explaining 84% of the variance in burned areas and 69.6% in the variance in fire frequency. These findings document the growing wildfire risk in the Northern Zagros region due to climate change, highlighting the urgent need to integrate scientific research with policies to develop effective wildfire management strategies for sustainable forest management.
Size Matters: Vocabulary Knowledge as Advantage in Partner Selection
Authors: Daller Michael , Ongun Zehra
Published: September 2024

Partner selection can be studied from different disciplines, such as psychology, sociology, and economics. However, linguistic perspectives have been neglected. That is why we need an interdisciplinary approach that includes language. The present article investigates how important the vocabulary size of a potential partner is for marital choice. Our theoretical framework is mainly that of biological markets which are still being widely used. This framework assumes that human decisions are made on a rational basis, e.g., about the characteristics that a potential partner brings into a marriage such as economic assets (wealth, education), psychological traits (intelligence, kindness, fairness), or signs that show physical and mental health. Partner selection takes place on a biological market where assets are displayed and are part of the negotiation for the best partner. We argue that vocabulary knowledge is such an asset, which is acquired through lengthy and costly education and distinguishes potential partners (or their parents) who can afford the accumulation of this form of human capital. Markets are not fully transparent and our knowledge about a potential partner might be incomplete or even distorted through false information or even cheating as one can clearly see from advertisements in online dating. However, we cannot pretend, at least not over a longer period of time, to know words that are not at our disposal. This present study is based on data from 83 couples after more than 15 years of marriage. Their vocabulary scores correlate highly and it is possible that this correlation is the result of accommodation through marriage. However, through partialling out statistically the years of marriage we conclude that the vocabulary size of each partner was an important factor already right at the beginning of their relationship. Those with higher human capital in vocabulary attract similar partners, and this holds for males and females as well as vice versa. Our participants are all Turkish–English sequential bilinguals and the question is whether it is vocabulary knowledge in the first or the second language that plays a crucial role in partner selection. Our results show that both languages are important. We argue that it is not knowledge of words at the surface level but that it is knowledge of conceptual concepts underlying both languages that serve as a display of human capital on the biological market of partner selection.
Methods for Screening and Isolating Extremely Heat-Resistant Escherichia coli from Meat Sources
Authors: Guragain Manita , Smith Gregory E. , Bosilevac Joseph M.
Published: September 2024

Meat animals harbor diverse E. coli populations in their digestive tracts and can serve as sources of pathogenic E. coli. The consumption of meat and produce contaminated with virulent E. coli from animal sources is associated with human illnesses and outbreaks. Heat treatment is an antimicrobial intervention that is commonly used during meat processing to ensure effective reductions in microbial load. Extreme heat resistance (XHR) has been reported among meat-borne E. coli and is mainly attributed to an ~15–19 kb genetic element known as the transmissible locus of stress tolerance (tLST). XHR E. coli can resist treatments used during meat processing and cooking. Therefore, the detection of heat-resistant E. coli is important for devising effective control measures to prevent meat spoilage and ensure meat safety. Here, we present methods used to (1) screen for tLST genes by multiplex PCR and (2) screen and isolate XHR E. coli from meat sources. The mode of heat exposure affects the outcome of XHR testing. Hence, the protocols were optimized to achieve maximum agreement between the tLST genotype and the XHR phenotype.
Postoperative Thrombocytopenia after Revision Arthroplasty: Features, Diagnostic and Therapeutic Considerations
Authors: Saguna Carmen , Berbec Nicoleta Mariana , Platon Marian , Marcoci Alexandra , Jercan Andreea , Colita Andrei , Gherghe Mihai Emanuel , Nedelea Dana-Georgiana , Cergan Romica , Scheau Cristian , Dragosloveanu Serban
Published: September 2024

We present the case of a 66 year-old male patient who developed severe postoperative thrombocytopenia after revision total hip arthroplasty. The patient underwent surgery in a dedicated orthopedics hospital and was initially managed in the intensive care unit. Upon the development of thrombocytopenia, he was referred to a dedicated hematology clinic for investigation and advanced management. A thorough diagnostic algorithm was employed in order to rule out the main causes of thrombocytopenia. By exclusion, we diagnosed the patient as suffering from a rare and severe form of postoperative thrombocytopenia through an immune mechanism. Although postoperative thrombocytopenia is relatively frequent but transitory and no treatment is required, this condition was refractory to corticosteroids and substitution therapy; however, it quickly responded to treatment with thrombopoietin receptor agonists. The patient recovered and was successfully discharged with normal platelet values. While rare occurrences, alternative causes of thrombocytopenia such as infection, drug-induced, or immune should be considered in patients developing postoperative thrombocytopenia.
Optimal Design of High-Precision Focusing Mechanism Based on Flexible Hinge
Authors: Huo Zhanwei , Li Guangzhen , Tan Luyang , Yang Tianwen , Tian Dapeng , Li Ji
Published: September 2024

A high-precision focusing mechanism was designed using a flexible hinge to address the demand for precise focusing in space cameras. Firstly, a finite element model of the liner guideway was created using Hertz contact theory, and the accuracy of the model was confirmed using the “flip method”. Subsequently, the flexible hinge was optimized by a mix of topological and integrated optimization. The simulation results demonstrated that the improved flexible hinge successfully eliminates interference between the liner guideway and the screw, minimizes the effects of initial assembly mistakes, and greatly reduces the tilt error of the focusing mechanism. Afterward, the focusing mechanism was subjected to a vibration test, which showed that its first-order fundamental frequency reached 163.28 Hz. This frequency is sufficiently high to minimize the risk of resonance during the launch phase. Ultimately, the tilt error of the focusing mechanism was assessed using both a rigid connector and a flexible hinge. The findings demonstrated that implementing the flexible hinge resulted in a 55.7% decrease in the range of Δθz and a 55.22% reduction in the standard deviation, effectively fulfilling the specified design requirements. This study indicates that the inclusion of a flexible hinge in the focusing mechanism leads to a substantial decrease in tilt error.
Solving Linear and Nonlinear Delayed Differential Equations Using the Lambert W Function for Economic and Biological Problems
Authors: Ruzgas Tomas , Jankauskienė Irma , Zajančkauskas Audrius , Lukauskas Mantas , Bazilevičius Matas , Kaluževičiūtė Rugilė , Arnastauskaitė Jurgita
Published: September 2024

Studies of the dynamics of linear and nonlinear differential equations with delays described by mathematical models play a crucial role in various scientific domains, including economics and biology. In this article, the Lambert function method, which is applied in the research of control systems with delays, is proposed to be newly applied to the study of price stability by describing it as a differential equation with a delay. Unlike the previous work of Jankauskienė and Miliūnas “Analysis of market price stability using the Lambert function method” in 2020 which focuses on the study of the characteristic equation in a complex space for stability, this study extends the application of this method by presenting a new solution for the study of price dynamics of linear and nonlinear differential equation with delay used in economic and biological research. When examining the dynamics of market prices, it is necessary to take into account the fact that goods or services are usually supplied with a delay. The authors propose to perform the analysis using the Lambert W function method because it is close to exact mathematical methods. In addition, the article presents examples illustrating the applied theory, including the results of the study of the dynamics of the nonlinear Kalecki’s business cycle model, which was not addressed in the previous work, when the linearized Kalecki’s business cycle model is studied as a nonhomogeneous differential equation with a delay.
The Concept of Topological Derivative for Eigenvalue Optimization Problem for Plane Structures
Authors: Carvalho Fernando Soares , Anflor Carla Tatiana Mota
Published: September 2024

This paper presents the topological derivative of the first eigenvalue for the free vibration model of plane structures. We conduct a topological asymptotic analysis to account for perturbations in the domain caused by inserting a small inclusion. The paper includes a rigorous derivation of the topological derivative for the eigenvalue problem along with a proof of its existence. Additionally, we provide numerical examples that illustrate the application of the proposed methodology for maximizing the first eigenvalue in plane structures. The results demonstrate that multiple eigenvalues were not encountered.
On One Approach to Obtaining Estimates of the Rate of Convergence to the Limiting Regime of Markov Chains
Authors: Satin Yacov , Razumchik Rostislav , Zeifman Alexander , Usov Ilya
Published: September 2024

We revisit the problem of the computation of the limiting characteristics of (in)homogeneous continuous-time Markov chains with the finite state space. In general, it can be performed only numerically. The common rule of thumb is to interrupt calculations after quite some time, hoping that the values at some distant time interval will represent the sought-after solution. Convergence or ergodicity bounds, when available, can be used to answer such questions more accurately; i.e., they can indicate how to choose the position and the length of that distant time interval. The logarithmic norm method is a general technique that may allow one to obtain such bounds. Although it can handle continuous-time Markov chains with both finite and countable state spaces, its downside is the need to guess the proper similarity transformations, which may not exist. In this paper, we introduce a new technique, which broadens the scope of the logarithmic norm method. This is achieved by firstly splitting the generator of a Markov chain and then merging the convergence bounds of each block into a single bound. The proof of concept is illustrated by simple examples of the queueing theory.
A Spatial Agent-Based Model for Studying the Effect of Human Mobility Patterns on Epidemic Outbreaks in Urban Areas
Authors: Topîrceanu Alexandru
Published: September 2024

The epidemic outbreaks of the last two decades have led governments to rely more on computational tools for establishing protection policies. Computational approaches to modeling epidemics traditionally rely on compartmental models, network models, or agent-based models (ABMs); however, each approach has its limitations, ranging from reduced realism to lack of tractability. Furthermore, the recent literature emphasizes the importance of points of interest (POIs) as sources of population mixing and potential outbreak hotspots. In response, this study proposes a novel urban spatial ABM validated using our augmented SICARQD epidemic model. To replicate daily activities more accurately, the urban area is divided into a matrix of points of interest (POIs) with agents that have unique paths that only permit infectious transmission within POIs. Our results provide a qualitative assessment of how urban characteristics and individual mobility patterns impact the infected population during an outbreak. That is, we study how population density, the total number of POIs (where the population concentrates), the average number of POIs visited by an agent, the maximum travel distance from the home location, and the quarantine ratio impact the dynamics of an outbreak. Our ABM simulation framework offers a valuable tool for investigating and controlling infectious disease outbreaks in urban environments with direct applicability to global policy makers.
Withdrawal/Withholding of Life-Sustaining Therapies: Limitation of Therapeutic Effort in the Intensive Care Unit
Authors: Becerra-Bolaños Ángel , Ramos-Ahumada Daniela F. , Herrera-Rodríguez Lorena , Valencia-Sola Lucía , Ojeda-Betancor Nazario , Rodríguez-Pérez Aurelio
Published: September 2024

Background/Objectives: The change in critically ill patients makes limitation of therapeutic effort (LTE) a widespread practice when therapeutic goals cannot be achieved. We aimed to describe the application of LTE in a post-surgical Intensive Care Unit (ICU), analyze the measures used, the characteristics of the patients, and their evolution. Methods: Retrospective observational study, including all patients to whom LTE was applied in a postsurgical ICU between January 2021 and December 2022. The LTE defined were brain death, withdrawal of measures, and withholding. Withholding limitations included orders for no cardiopulmonary resuscitation, no orotracheal intubation, no reintubation, no tracheostomy, no renal replacement therapies, and no vasoactive support. Patient and ICU admission data were related to the applied LTE. Results: Of the 2056 admitted, LTE protocols were applied to 106 patients. The prevalence of LTE in the ICU was 5.1%. Data were analyzed in 80 patients. A total of 91.2% of patients had been admitted in an emergency situation, and 56.2% had been admitted after surgery. The most widespread limitation was treatment withholding (83.8%) compared to withdrawal (13.8%). No differences were found regarding who made the decision and the type of limitation employed. However, patients with the limitation of no intubation had a longer stay (p = 0.025). Additionally, the order of not starting or increasing vasopressor support resulted in a longer hospital stay (p = 0.007) and a significantly longer stay until death (p = 0.044). Conclusions: LTE is a frequent measure in critically ill patient management and is less common in the postoperative setting. The most widespread measure was withholding, with the do-not-resuscitate order being the most common. The decision was made mainly by the medical team and the family, respecting the wishes of the patients. A joint patient-centered approach should be made in these decisions to avoid futile treatment and ensure end-of-life comfort.
Hidradenitis Suppurativa in Elderly Patients: Clinical and Therapeutical Outcomes—A Review of the Literature
Authors: Martora Fabrizio , Tommasino Nello , Brescia Claudio , Potestio Luca , Battista Teresa , Megna Matteo
Published: September 2024

The management of hidradenitis suppurativa (HS) in elderly patients presents unique challenges due to its chronic inflammatory nature, heterogeneous clinical presentation and comorbidities. While HS typically affects the anogenital and intertriginous regions, elderly patients may exhibit atypical features such as the involvement of the neck, mammary area and gluteal region. The prevalence of HS in the elderly population is lower and the average age of disease onset is higher than in patients under 65. In contrast, it is unclear whether HS in the elderly has different clinical features. The elderly frequently present multiple comorbidities, including obesity, diabetes, and heart disease, which further complicate management decisions. Therapeutic interventions must consider the frailty and increased risk of multimorbidity and adverse events in elderly patients. While systemic antibiotics remain a mainstay of HS treatment, biologic agents such as TNFα inhibitors and secukinumab offer promising options for refractory cases. However, their safety and efficacy in elderly patients, particularly those with multiple comorbidities, require careful consideration. A comprehensive approach to managing HS in elderly patients involves not only pharmacological interventions but also lifestyle modifications and surgical options where appropriate. Multidisciplinary collaboration between dermatologists, geriatricians and other specialists is essential for tailoring treatment strategies and optimizing long-term outcomes and quality of life in special population.
Research on Microstructural Evolution Behavior of Ni-Based Single-Crystal Alloy with Re Based on Non-Linear Ultrasonic Lamb Wave and Molecular Dynamics Method
Authors: Li Ben , Zhang Yilin , Zhou Hongyan , Li Xuewu
Published: September 2024

Interface dislocation networks have a great influence on the mechanical properties of the new Ni-based single-crystal alloy (NSC) containing Re, but it is difficult to find out the structural evolution behaviors at the micro-level. Thus, molecular dynamics (MD) simulation is used to analyze the atomic potential energy change and dislocation evolution mechanism, and non-linear characteristic parameters are used to analyze the microstructure evolution of NSC. First, a new model of Ni-Al-Re that is closer to the real properties of the material is established using the MD method according to the optimal volume ratio of matrix phase to precipitate phase. Then, the MD models of NSC with different contents of Re are calculated and analyzed under compressive and tensile loads. The results show that with an increase in Re atoms, the atomic potential energy at the interface dislocation networks is reduced; thus, the stability of the system is enhanced, and the hindrance of the interface dislocation networks to the dislocation movement of the matrix phase is strengthened. At the same time, the number of HCP structures and OISs formed by the destruction of the intact FCC structures also decreases. In the non-linear ultrasonic experiment, with the increase in Re atoms, the non-linear enhancement of the microstructure of the NSC leads to an increase in the corresponding non-linear characteristic parameters. Accordingly, the microstructural evolution behaviors of the phase interface of the new NSC can be effectively explored using the combination of MD simulation and non-linear ultrasonic experimentation. The results of this study lay a foundation for the subsequent research of the microscopic defects of NSCs by using ultrasonic phased-array technology.
Effect of Atomic Ordering on Phase Stability and Elastic Properties of Pd-Ag Alloys
Authors: Chen Xiaoli , Luo Guangxiong , Cao Yuxuan , Liang Chaoping
Published: September 2024

Palladium (Pd) and its alloys, renowned for their good corrosion resistance, catalytic efficiency, and hydrogen affinity, find extensive use in various industrial applications. However, the susceptibility of pure Pd to hydrogen embrittlement necessitates alloying strategies such as Pd-Ag systems. This study investigates the impact of the ordering on the phase stability and elastic properties of Pd-Ag alloys through first-principles calculations. We explore a series of ordered phase structures alongside random solid solutions using Special Quasirandom Structures (SQSs), evaluating their thermodynamic stability and elastic properties. Our findings indicate the possible existence of stable ordered L12 Pd3Ag and PdAg3 and L11 PdAg phases, which are thought to exist only in Cu-Pt alloys. An analysis of the elastic constants and anisotropy indices underscores some pronounced directional dependencies in the mechanical responses between the random solid-solution and ordered phases. This suggests that the ordered phases not only are thermodynamically and mechanically more stable than solid-solution phases, but also display a decrease in anisotropy indices. The results provide a deeper understanding of the atomic behavior of Pd-Ag alloys, and shed light on the design of multiphase Pd-Ag alloys to improve their mechanical properties.
A Review of Molecular Dynamics Simulation of Different Ti-Al-Based Alloys
Authors: Li Ningning , Hao Zhenjie , Xu Lei , Tang Mingqi , Wei Leyu , Wang Lifei
Published: September 2024

Ti-Al-based alloys, particularly two-phase TiAl and Ti3Al alloys, have garnered significant attention as potential replacements for various high-temperature structural materials due to their exceptional properties, including low density, oxidation resistance, and high strength at elevated temperatures. Despite these advantages, experimental studies on the microstructure evolution of Ti-Al-based alloys under complex conditions remain challenging to observe and characterize. This review article examines the current research on molecular dynamics (MD) simulations of Ti-Al-based alloys, focusing on two-phase Ti-Al alloys, Ti-Al amorphous alloys, Ti-Al composite materials, and the welding and multi-layer/film applications of Ti-Al alloys. This review highlights the unique capabilities of MD simulations in predicting the behavior of Ti-Al-based alloys and addresses existing scientific challenges. Furthermore, this article discusses future research directions and development prospects in this field.
Corrosion Properties and Surface Chemistry of Graphene Oxide-Coated AZ91D Magnesium Alloy in Sodium Chloride Solution
Authors: da Silva Nathalia Sartori , Alves Aila Cossovan , da Silva Pereira Jaine Aparecida , de Oliveira Leandro Antonio , de Oliveira Mara Cristina Lopes , Antunes Renato Altobelli
Published: September 2024

In the present work, the corrosion properties and the surface chemistry of a graphene oxide-coated AZ91D alloy were investigated. The coatings were deposited on the substrate specimens by immersion in solutions with GO concentrations of 0.05% and 0.1% (m/v). An intermediate silane layer was firstly obtained to improve adhesion between the GO films and the AZ91D substrate. The electrochemical behavior of the coated specimens was assessed using electrochemical impedance spectroscopy and potentiodynamic polarization curves in 3.5 wt.% NaCl solution. The surface chemistry was assessed using X-ray photoelectron spectroscopy (XPS). The GO films consisted of a mixture of carbon-based bonds (C-C, C-OH, C=O, and O-C=O). The surface morphology of the coated specimens was examined using scanning electron microscopy. The results revealed that the compactness of the GO films was dependent on the deposition conditions. The corrosion resistance was affected by the surface morphology.