bluuebunny/crossref_metadata_2025 huggingface dataset:
THE PROFESSIONALLY-COMMUNICATIVE COMPETENCY OF А FOREIGN MEDICAL STUDENT
Authors:   Вищий державний навчальний заклад України  “Буковинський державний медичний університет”, TSURKAN M.
Published: January 2020

Aim of investigation – to describe and outline the content of such concepts as “competence”, “competency”, “communicative competency”, “professional competency”, “professionally-communicative competency” of a foreign student-medic under conditions of inter-ethnic cultural communication. Methodology of investigation – is based on complex combination of theoretical methods of applied linguistics, psycho-linguistics, linguo-didactics with the aim of definition of conceptual principles of the investigation. Scientific novelty of the investigation consists in the attempt of holistic comprehension of linguistic category «professionally-communicative competency» of a foreign student-medic. Conclusions. It has been determined, that competence – is integrated quality (attribute) or complex characteristic of a personality, that combines desire, readiness and ability to implement activity (to achieve set goal, solve problems, adjust tasks, analyze situation, make decisions, control personal and unfamiliar actions, qualified and creatively realize the potential, etc.) in a certain professional sphere; on the basis of previously gained competencies; competency – is a complex of knowledge, imaginations, skills, habits and attitudes that are formed in the process of education and are applied in a certain sphere of activity; professional competency – complex of knowledge from professionally-oriented disciplines (anatomy, physiology, histology, pharmacology, etc.) and ability to practically apply them in professional activity. It has been investigated, that professionally-communicative competency of a foreign student-medic – is a complicated psychologically-pedagogical category, that on our opinion integrates professional knowledge (collecting anamnesis, recognition of the disease and setting a diagnosis, prescribing treatment, etc.), independent and creative composition of thinking (ability to analyze the process, efficiency and final result of a treatment; ability to evaluate not only achievement in personal work, but to see the reasons of failures), communicative skills (possessing of generally used and professional vocabulary, correct and relevant selection of language tools, logical and consistent building of expression, appropriate diction, ability to listen, arrangement of medical documents: references, protocol of a surgery, medical case or an abstract, etc.), moral values (tolerance, tactfulness, patience, sensitiveness, empathy, politeness, cordiality, benevolence, etc.). Key words: competence, competency, communicative, professional, professionally-communicative competency, foreign student-medic.
PROBLEMS OF TRAINING OF A COMPETENT TEACHER OF PHYSICS IN THE FRAMEWORK OF IMPLEMENTATION OF THE NEW SCHOOL PROJECT
Authors:   Національний педагогічний університет  імені М.П. Драгоманова, SHUTE M. , BLAGODARENKO L. ,   Національний педагогічний університет  імені М.П. Драгоманова
Published: January 2020

The article is devoted to the research of the problems that led to the crisis in science education in general and the training of physics teachers in particular. It is emphasized that for our country the tendency to increase the humanitarian component in the education system has become harmful. Based on the analysis of the results of the introductory campaigns of the last years, it is ascertained that today there is a pronounced shift towards the specialties of humanitarian and social orientation. The opinion was expressed and substantiated that the Ministry of Education and Science of Ukraine should review the approaches to state procurement planning, which should be tailored to the needs of industries and the balance of labor resources, and not the demand of entrants. It is emphasized that the restoration and replenishment of the scientific and technical potential of Ukraine should start with giving priority to the training of physics teachers and correcting the situation with a specialty “Secondary education (physics)”, since otherwise in the near future competent teachers will not remain in secondary education institutions. Concerns have been expressed about the fact that under such conditions it will not be possible to provide specialized education, which will lead to further decline of physical and physical and technical education, and ultimately to the intellectual degeneration of our people. Priority measures for improvement of the state of preparation of the teacher of physics in Ukraine and increase of its prestige are offered, among which are highlighted such as revival of work of physical-mathematical pedagogical classes at institutions of pedagogical higher education, improvement and expansion for pupils of such classes and schools of higher education. to institutions of pedagogical higher education, renewal of the target set of students in the specialty “Secondary education (physics)”. It is noted that to prepare highly competent Ukrainian physics teachers who will be able to implement the New Ukrainian School project, it takes time and a set of activities that can be implemented only through the joint efforts of the entire teaching community. Key words: physical and physical-technical education, training of physics teacher.
THE USE OF MULTIMEDIA IN THE SYSTEM OF METHODS AND TECHNIQUES OF TEACHER'S WORK IN THE SPEECH DEVELOPMENT OF PRIMARY SCHOOL PUPILS
Authors:   Житомирський державний університет імені Івана Франка, CHUPRINA O.
Published: January 2020

The article explores the peculiarities of the use of multimedia in the system of methods and techniques of work on the speech development of primary school pupils. The content of the concepts of "method", "reception" is outlined, the attention is paid to the system of work on the speech development, aimed at enriching the vocabulary of pupils, the development of the grammatical structure of their speech; mastering the norms of the Ukrainian literary language; developing the ability to perceive, reproduce and construct oral and written utterances. The expediency of using multimedia means, which are intended to optimize the process of speech development of primary school pupils and which are relevant in the conditions of formation and development of the New Ukrainian school. Key words: method, admission, multimedia, speech development, elementary school.
Features of Epidemic Process of Influenza and its Etiology in the Countries of the Northern and Southern Hemispheres in the Period of Circulation of Pandemic Virus A(H1N1)pdm09 (According to WHO)
Authors: Karpova L. S. , Pelikh M. Yu. , Popovtseva N. M. , Stolyarova T. P , Volik K. M.
Published: January 2020

Relevance. Influenza is characterized by global distribution and the difference in its seasonality in countries with temperate and tropical climates. The importance of studying antigenic variation of influenza viruses due to the fact that changes in the antigenic structure is an evolutionary mechanism of adaptation of the virus to ensure its survival and cause annual epidemics.

Aims. The Aim of this study was to identify the peculiarities of the geographical spread of influenza (seasonal), etiology and the rate of antigenic variability of influenza viruses A and B.

Materials and methods. Based on data from WHO Reference research centers, information was collected on circulating influenza virus strains from 1975 A(H3N2), 1977 A(H1N1)pdm09 and type B of the Yamagata and Victoria lines from 1987 to 2019, as well as data on the number of all identified influenza viruses and individual strains circulating in the Northern and Southern hemispheres from 2008 to 2018.

Results and discussion. Analysis of the global spread of influenza, its etiology and antigenic variability of viruses, according to WHO, showed that the influenza A(H1N1)pdm09 virus was the main causative agent of epidemics and regional outbreaks in seasons of high influenza activity in all countries except the United States and Canada, where influenza A(H3N2) and B viruses dominated in countries with severe seasonality, the change of season led to a change in the etiology of influenza, and in tropical countries, the A(H1N1)pdm09 virus more often remained dominant in all seasons of the year.

Conclusions. The pronounced seasonality of influenza in Northern countries and its absence in tropical countries, where regional outbreaks prevailed in all seasons of the year, were confirmed. Low antigenic variability of influenza A(H1N1)pdm09 strains was confirmed, and the highest – A(H3N2). Among influenza B strains in the Victoria line had less antigenic variability, because the duration of its circulation before the appearance of a new drift variant was longer than that of the Yamagata line. The tendency to increase the total duration of circulation of influenza viruses B/Victoria, A(H1N1)pdm09 and B/Yamagata due to increased circulation before the emergence of new drift variants is shown.
Clinical and angioarchitectural characteristics of spinal vascular malformations of the cervical spine
Authors: Brinjikji Waleed , Colombo Elisa , Lanzino Giuseppe
Published: January 2020

OBJECTIVE

Vascular malformations of the cervical spine are exceedingly rare. To date there have been no large case series describing the clinical presentation and angioarchitectural characteristics of cervical spine vascular malformations. The authors report their institutional case series on cervical spine vascular malformations diagnosed and treated at their institution.

METHODS

The authors retrospectively reviewed all patients with spinal vascular malformations from their institution from January 2001 to December 2018. Patients with vascular malformations of the cervical spine were included. Lesions were characterized by their angioarchitectural characteristics by an interventional neuroradiologist and endovascular neurosurgeon. Data were collected on clinical presentation, imaging findings, treatment outcomes, and long-term follow-up. Descriptive statistics are reported.

RESULTS

Of a total of 213 patients with spinal vascular malformations, 27 (12.7%) had vascular malformations in the cervical spine. The mean patient age was 46.1 ± 21.9 years and 16 (59.3%) were male. The most common presentations were lower-extremity weakness (13 patients, 48.1%), tetraparesis (8 patients, 29.6%), and lower-extremity sensory dysfunction (7 patients, 25.9%). Nine patients (33.3%) presented with hemorrhage. Fifteen patients (55.6%) had modified Rankin Scale scores of 0–2 at the time of diagnosis. Regarding angioarchitectural characteristics, 8 patients (29.6%) had intramedullary arteriovenous malformations (AVMs), 5 (18.5%) had epidural arteriovenous fistulas (AVFs), 4 (14.8%) had paraspinal fistulas, 4 (14.8%) had mixed epidural/intradural fistulas, 3 (11.1%) had perimedullary AVMs, 2 (7.4%) had dural fistulas, and 1 patient (3.7%) had a perimedullary AVF.

CONCLUSIONS

This retrospective study of 27 patients with cervical spine vascular malformations is the largest series to date on these lesions. The authors found substantial angioarchitectural heterogeneity with the most common types being intramedullary AVMs followed by epidural AVFs, paraspinal fistulas, and mixed intradural/extradural fistulas. Angioarchitecture dictated the clinical presentation as intradural shunts were more likely to present with hemorrhage and acute onset myelopathy, while dural and extradural shunts presented as either incidental lesions or gradually progressive congestive myelopathy.
ANALISIS PENGARUH MOTIVASI TERHADAP KEPUASAN KERJA TENAGA PENYULUH KESEHATAN PADA DINAS KESEHATAN KOTA PAREPARE
Authors: Andi Nasir  , Sabrina
Published: January 2020

Penilaian terhadap kepuasan pekerjaan memberikan arti bagi individu, yang memberikan kewenangan untuk membuat keputusandan memecahkan persoalan pekerjaan yang bervariasi dan saling mendukung guna menimbulkan penghargaan atau pengakuan serta memberi umpan balik bagi kinerja. Penelitian ini bertujuan untuk mengetahui pengaruh motivasi kerja intrinsik dan ekstrinsik tenaga penyuluh kesehatan pada Dinas Kesehatan Kota Parepare. Jenis penelitian ini adalah survey analitik dengan rancangan Cross Sectional Study dengan sampelnya 73 orang tenaga penyuluh kesehatan. Data tersebut di olah dengan uji statistik regresi logistic. Hasil penelitian menunjukkan bahwa ada pengaruh prestasi, pengakuan, pengembangan, tunjangan fungsional dan kelengkapan fasilitas operasional terhadap tingkat kepuasan tenaga penyuluh kesehatan Dinas Kesehatan Kota Parepare. Adapun variabel bebas yang paling berpengaruh terhadap kepuasan kerja tenaga penyuluh kesehatan adalah kelengkapan fasilitas operasional. Fakta ilmiah adanya semangat kerja bagi tenaga penyuluh kesehatan bilamana termotivasi oleh faktor pendukung dan penunjang dalam melaksanakan tugas sesuai profesi keahliannya sebagai tenaga fungsional
PENGETAHUAN SIKAP DAN TINDAKAN PETUGAS PUSKESMAS TERHADAP SISTEM PENGELOLAAN SAMPAH MEDIS DI PUSKESMAS LUMPUE KOTA PAREPARE
Authors: Muh. Adrianto  , H. Ramlah  , H. Abdul Madjid
Published: January 2020

Dewasa ini limbah merupakan masalah yang cukup serius, terutama dikota-kota besar, sehingga banyak upaya yang dilakukan oleh pemerintah daerah, swasta maupun secara swadaya oleh masyarakat untuk menanggulanginya, dengan cara mengurangi, mendaur ulang maupun memusnahkannya. Sampah medis adalah bahan buangan yang dihasilkan dari kegiatan pelayanan medis baik diagnose maupun terapi kepada pasien. Tujuan penelitian ini untuk mengetahui gamabaran pengetahuan sikap dan tindakan petugas puskesmas terhadap sistem pengelolaan sampah medis di Puskesmas Lumpue Kota Parepare. Metode yang digunakan dalam penelitian ini adalah bersifat menggambarkan atau deskriptif. Analisa data menggunakan analisa univariat. Berdasarkan hasil penelitian diperoleh gambaran pengetahuan petugas Puskesmas Lumpue Kota Parepare dengan kategori tinggi yaitu 51,0%, tingkat sedang 38,8% dan rendah 10,2%. Sedangkan gambaran sikap dan tindakan petugas Puskesmas Lumpue Kota Parepare dengan kategori baik yaitu 91,8% dan kategori kurang baik 8,2%. Berdasarkan penelitian ini tingkat pengalaman kerja seseorang sudah dapat memberikan sumbangan pengetahuan tentang pengelolan sampah medis. Sedangkan sikap dan tindakan petugas puskesmas tentang sistem pengelolaan sampah medis sudah baik. Hal ini disebabkan karena sudah tersedianya fasilitas-fasilitas yang menunjang terlaksananya sistem pengelolaan sampah medis di Puskesmas Lumpue Kota Parepare
HUBUNGAN ANTARA KARAKTERISTIK PENDERITA DENGAN DERAJAT ASMA BRONKIAL DI RUMAH SAKIT UMUM DAERAH ANDI MAKKASAU KOTA PAREPARE
Authors: Andi Khaidir  , Usman  , Henni Kumaladewi Hengky
Published: January 2020

Asma merupakan gangguan inflamasi kronis di jalan napas. Dasar penyakit ini adalah hiperaktivitas bronkus dan obstruksi jalan napas. Gejala asma adalah gangguan pernapasan (sesak), batuk produktif terutama pada malam hari atau menjelang pagi, dan dada terasa tertekan. Tujuan penelitian ini  untuk menunjukkan apakah umur, jenis kelamin, pendidikan terakhir, tingkat pendapatan, faktor genetik dan lingkungan mempengaruhi derajat asma bronkial di Rumah Sakit Umum Daerah Andi Makkasau Kota Parepare. Metode yang digunakan dalam penelitian ini adalah metode analitik dengan pendekatan Cross Sectional Survey. Peneliti mengidentifikasi melalui observasional dengan menggunakan kuesioner pada sampel, dimana sampel dalam penelitian ini sebanyak 60 orang. Data dianalisis secara univariat dan bivariat  menggunakan uji statistik Chi Square  melalui SPSS Versi 24. Hasil penelitian menunjukkan bahwa umur (0,000), pendidikan terakhir (0,011), tingkat pendapatan (0,017), faktor genetik (0,037) dan lingkungan (0,017) berpengaruh terhadap derajat asma bronchial sedangkan jenis kelamin (0,875) tidak berpengaruh terhadap Derajat Asma Bronkial di Rumah Sakit Umum Daerah Andi Makkasau Kota Parepare. Berdasarkan hasil penelitian yang diperoleh, diharapkan bagi penderita asma sebaiknya rajin melakukan pengontrolan kesehatan sehingga derajat asma tidak semakin parah.
PENGARUH INTENSITAS KEBISINGAN TERHADAP FREKUENSI DENYUT NADI PADA PEKERJA PENGGILINGAN GABAH DI DESA SANGLEPONGAN KECAMATAN CURIO KABUPATEN ENREKANG
Authors: Masdi  , Rahmi Amir  , Amir Pantintingan
Published: January 2020

Kebisingan merupakan salah satu masalah kesehatan lingkungan dan kesehatan kerja.Bising adalah suara yang tidak dikehendaki yang dapat menganggu dan atau dapat membahayakan kesehatan. Berdasarkan kepmenaker,kebisingan adalah suara yang tidak dikehendaki yang bersumber dari alat-alat, proses produksi yang pada tingkat tertentu dapat menimbulkan gangguan kesehatan dan pendengaran Tujuan dari penelitian ini adalah untuk mengetahui pengaruh intensitas kebisingan dengan frekuensiDenyut Nadi pada Pekerja penggilingan Gabah Di Desa Sanglepongan Kecamatan Curio Kabupaten Enrekang, dan Untuk mengetahui dampak kesehatan bagi pekerja penggilingan gabah di Desa Sanglepongan Kecamatan Curio Kabupaten Enrekang. Metode dalam penelitian ini adalah survei analitik dengan pendekatan cross sectional. Berdasarkan hasil penelitian dan uji statistic yang telah dilakukan dihasilkan t hitung yakni 6,000 dengan tingkat signifikansi yakni 0,000 yang artinya ada perbedaan antara frekuensi denyut nadi sebelum dan setelah terpapar kebisingan.
STUDI TENTANG MOTIVASI KERJA TENAGA NON PNS DI PUSKESMAS PERAWATAN CEMPAE KOTA PAREPARE
Authors: Hardianti Merdekawati  , Usman  , Makhrajani Majid
Published: January 2020

Motivasi pada dasarnya adalah kondisi mental yang mendorong dilakukannya suatu tindakan (action atau activities)  dan memberikan kekuatan yang mengarah kepada pencapaian kebutuhan, memberi kepuasan ataupun mengurangi ketidakseimbangan. Tujuan penelitian adalah Untuk mengetahui dan menganalisis kebijakan pimpinan, hubungan antar manusia dan  kondisi kerja terhadap motivasi kerja di Puskesmas Perawatan Cempae Kota Parepare. Penelitian menggunakan metode penelitian deskriptif dengan pendekatan survey yaitu suatu metode penelitian yang dilakukan dengan tujuan utama untuk mengetahui gambaran atau deskriptif tentang suatu keadaan secara objektif. Populasi dalam penelitian ini adalah seluruh tenaga Non PNS di Puskesmas Cempae sebanyak 53 orang. Teknik pengambilan sampel dilakukan dengan teknik total sampling yaitu semua anggota populasi dijadikan sampel yaitu sebanyak 53 tenaga Non PNS. Analisis data menggunakan analisis univariat dan deskriptif. Hasil penelitian menunjukkan ada hubungan kebijakan pemimpin yaitu cukup baik sebanyak (41,5%), sangat baik sebanyak (39,6%) dan baik sebanyak (18,9%). Hubungan denga rekan kerja yaitu baik sebanyak (58,5%), cukup baik sebanyak (24,5%) dan sangat baik sebanyak (17,0%). Kondisi kerja yakni cukup baik sebanyak (52,8%), baik sebanyak (45,3%) dan sangat baik sebanyak (1,9%) terhadap motivasi kerja tenaga Non PNS di Puskesmas Cemape Kota Parepare. Kesimpulan penelitian adalah motivasi tenaga Non PNS di Puskesmas Cempae Kota Parepare  tahun 2018 adalah sangat baik sebanyak 29 responden  (54,7%), cukup baik sebanyak 23 responden (43,4%) sedangkan kurang baik sebanyak 1 perawat (1,9%).
Whole blood viscosity is an independent early predictor for metabolic syndrome and its components in men: A prospective cohort study in Northern Chinese population
Authors: Zhang Guang , Zhang Tao , Sun Xiubin , Tang Fang , Lin Haiyan , Liu Yanxun , Zhang Chengqi , Xue Fuzhong
Published: January 2020

The association between whole blood viscosity (WBV) and metabolic syndrome (MetS) is still scarcely investigated in the population-based prospective cohort. We aim to explore the longitudinal effect of WBV on MetS, and to verify whether WBV measures can be used as early predictors for MetS. The longitudinal cohort consisted of 3,508 adults (2,350 males and 1,158 females) who visited the health check-up system twice. WBV were measured at four shear rate (200, 50, 10 and 1 s-1), and their values were classified into quartiles. Multivariate Cox models were used to estimate the adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) in men and women, respectively. A total of 444 (12.66%) incident MetS were observed at follow-up period. The incidences of MetS significantly increased with increasing quartiles of WBVs at all of the shear rate in men. After adjusting for baseline age, smoking, obesity, hypertension, hyperglycemia, and hyperlipidemia status, all of the WBV measures were significantly associated with incident MetS in men, and the HRs showed clear increasing trend across the quartiles of baseline WBVs. There were no significant association between WBVs and incident MetS in women. These findings suggest that MetS has a hemodynamic basis, and WBVs could be used as independent early predictor for MetS in men.
Cerebrospinal Fluid Levels of Interleukin-8 in Delirium, Dementia, and Cognitively Healthy Patients
Authors: Sajjad Muhammad Umar , Blennow Kaj , Knapskog Anne Brita , Idland Ane-Victoria , Chaudhry Farrukh Abbas , Wyller Torgeir Bruun , Zetterberg Henrik , Watne Leiv Otto
Published: January 2020

Background:

Delirium is a common and serious complication in geriatric patients. The pathophysiology of delirium is not known.

Objective:

The objective of the current study was to test the hypothesis that cerebrospinal fluid (CSF) levels of inflammatory markers at the time of spinal anesthesia for hip surgery are associated with delirium.

Methods:

In total 133 hip fracture patients and 125 cognitively healthy controls undergoing elective surgery, together with 73 Alzheimer’s disease (AD) dementia patients, were recruited at Oslo University Hospital and Diakonhjemmet Hospital, Oslo, Norway. Delirium was evaluated daily in hip fracture patients by the Confusion Assessment Method (CAM). Depression was evaluated by Cornell Scale for Depression in Dementia (CSDD). Tumor necrosis factor alpha (TNF- α), interleukin-1beta (IL-1β), and interleukin-8 (IL-8) levels were measured in CSF using a Mesoscale Discovery (MSD) immunoassay.

Results:

Hip fracture patients had significantly higher IL-8 levels ( p < 0.001) compared to cognitively healthy controls or patients with stable AD dementia. Furthermore, preoperative IL-8 levels were significantly higher ( p = 0.013) in hip fracture patients who developed delirium (incident delirium) after surgery as compared to patients with no delirium. However, subgroup analyses showed that IL-8 levels were only significantly higher in delirium patients without dementia ( p = 0.006). In contrast, depression subgroup analysis showed that IL-8 concentration was significantly higher ( p = 0.002) in delirium patients with depression. Both TNF- α and IL-1β were undetected in most patients.

Conclusions:

Our study suggests that IL-8 levels are associated with delirium onset and that underlying depression or dementia influences IL-8 levels.
Single-Nucleotide Polymorphisms Associated with the Senescence-Accelerated Phenotype of OXYS Rats: A Focus on Alzheimer’s Disease-Like and Age-Related-Macular-Degeneration-Like Pathologies
Authors: Devyatkin Vasiliy A. , Redina Olga E. , Kolosova Nataliya G. , Muraleva Natalia A.
Published: January 2020

Alzheimer’s disease (AD) and age-related macular degeneration (AMD) are two complex incurable neurodegenerative disorders the common pathogenesis of which is actively discussed. There are overlapping risk factors and molecular mechanisms of the two diseases; at the same time, there are arguments in favor of the notion that susceptibility to each of these diseases is associated with a distinct genetic background. Here we identified single-nucleotide polymorphisms (SNPs) that are specific for senescence-accelerated OXYS rats, which simulate key characteristics of both sporadic AD and AMD. Transcriptomes of the hippocampus, prefrontal cortex, and retina (data of RNA-Seq) were analyzed. We detected SNPs in genes Rims2, AABR07072639.2, Lemd2, and AABR07045405.1, which thus can express significantly truncated proteins lacking functionally important domains. Additionally, 33 mutations in genes—which are related to various metabolic and signaling pathways—cause nonsynonymous amino acid substitutions presumably leading to disturbances in protein structure or functions. Some of the genes carrying these SNPs are associated with aging, neurodegenerative, and mental diseases. Thus, we revealed the SNPs can lead to abnormalities in protein structure or functions and affect the development of the senescence-accelerated phenotype of OXYS rats. Our data are consistent with the latest results of genome-wide association studies that highlight the importance of multiple pathways for the pathogenesis of AD and AMD. Identified SNPs can serve as promising research objects for further studies on the molecular mechanisms underlying this particular rat model as well as for the prediction of potential biomarkers of AD and AMD.
Baseline and early 3D-CUBE volume reconstruction of locally advanced rectal cancer to predict tumor response after neoadjuvant chemotherapy
Authors: Wang Xin-Hua , Liu Zheng-Jun , Xu Jian-Bo , Li Fang-Qian , Li Wen-Li , Cao Wu-Teng , Zhou Zhi-Yang
Published: January 2020

PURPOSE:

To explore whether volumetric measurements of 3D-CUBE sequences based on baseline and early treatment time can predict neoadjuvent chemotherapy (NCT) efficacy of locally advanced rectal cancer (LARC).

MATERIAL AND METHOD:

73 patients with LARC were enrolled from February 2014 to January 2018. All patients underwent MRIs during the baseline period before NCT (BL-NCT) and the first month of NCT (FM-NCT), and tumor volume (TV) was measured using 3D-CUBE, and tumor volume reduction (TVR) and tumor volume reduction rate (TVRR) were calculated. In addition, tumor invasion depth, tumor maximal length, range of tumor involvement in the circumference of intestinal lumen and distance from inferior part of tumor to the anal verge were measured using baseline high-spatial-resolution T2-weighted MRIs. All patients were categorized into sensitive and insensitive groups based on post-surgical pathology after completion of the full courses of NCT. The receiver operating characteristic (ROC) curve was used to analyze the value of different MRI parameters in predicting efficacy of NCT.

RESULTS:

Statistically significant differences in TV of BL-NCT, TVR and TVRR from BL-NCT to FM-NCT were detected between sensitive and insensitive groups ( P < 0.05, respectively). The areas under the curves (AUC) of ROC of TVR and TVRR in predicting efficacy of NCT (0.890 [95% CI, 0.795∼0.951], 0.839 [95% CI, 0.735∼0.915]) were significantly better than that of TV (0.660 [95% CI, 0.540∼0.767]) ( P < 0.05, respectively).

CONCLUSION:

Reconstruction of 3D-CUBE volume in the first month of NCT is necessary, and both TVR and TVRR can be used as early predictors of NCT efficacy.
Udder properties and productive longevity of cows of different breeds with intensive milking technology
Authors: Stepanova Yu.
Published: January 2020

Abstract. The aim of the research is a comparative assessment of the morphological and functional properties of the udder, productive longevity of cows of Black-Mottled and Simmental breeds. Methods. The work was carried out on the basis of an agricultural enterprise of the Tyumen region, where a loose method of keeping cows and voluntary milking by a robot is used. In the first group – cows of Black-Mottled breed, in the second – Simmental. Results. Cows of the first group of the Black-Mottled breed had a uniformly developed udder with an index of 45.1 % and were superior to animals of the second group of the Simmental breed: in girth by 7.2 cm (5.4 %) (p < 0.001) and width by 1.0 cm (5.0%) (p < 0.001). The indicator characterizing the capacity of the udder in animals of the black-mottled breed is greater than in simmentals by 295.2 cm2 (10.0 %) (p < 0.05). The difference in the rate of milk yield of cows was 0.05 kg / min (2.3 %) in favor of simmentals. The period of production use of Black-Mottled cows is longer than this indicator in simmentals by 0.4 lactation (p < 0.001). Animals of the Black-Mottled breed gave 2471.0 kg (p < 0.001) more milk over the entire period of use compared to animals of the Simmental breed. In addition, in Black-Mottled cows, the amount of milk fat and milk protein during the life period exceeds simmentals by 86.3 and 72.3 kg (p < 0.001). Novelty. When using the developed method of selecting highly productive cows, it makes it possible to get more milk from cows per day by 1.4 kg (6.7 %), for 305 days – by 268.1 kg (5.4%), for the period of life – by 1684.4 kg (9.7%). This method allows you to extend the period of economic use of the dairy herd by 0.4 lactation (14.8 %).
The Role of Tumor-Derived Vesicles in the Regulation of Antitumor Immunity
Authors: Ukrainskaya V. M. , Rubtsov Y. P. , Knorre V. D. , Maschan M. A. , Gabibov A. G. , Stepanov A. V.
Published: January 2020

In this article, we present a comprehensive, updated, and elucidative review of the current knowledge on the function played by tumor-derived vesicles (TDVs) in the crosstalk between tumor and immune cells. Characterization of the structure, biogenesis, and the major functions of TDVs is reported. The review focuses on particular ways of suppression or activation of CD4+/CD8+ Т cells by tumor-derived vesicles. Tumor-derived vesicles play an important role in the suppression of antitumor immunity. During the last 15 years, vesicle research has elucidated and improved our knowledge about the role of the vesicles in intercellular communication. Nevertheless, there are still blinds spots concerning vesicle heterogeneity and isolation methods, their uptake by target cells, and the role of mRNA in T-cell transformation or suppression. Along with the substantial progress in understanding of the role of tumor-derived vesicles in intercellular communication, novel antitumor therapy strategies based on vesicle inhibition in a tumor microenvironment are likely to appear very soon.
Genetic Variability of the AcrAB-TolC Multidrug Efflux Pump Underlies SkQ1 Resistance in Gram-Negative Bacteria
Authors: Nazarov P. A. , Kotova E. A. , Skulachev V. P. , Antonenko Y. N.
Published: January 2020

SkQ1, a novel antibiotic targeting bacterial bioenergetics, is highly effective against both gram-positive and gram-negative bacteria. However, some gram-negative bacteria, such as Escherichia coli and Klebsiella pneumoniae, are highly resistant to it. In different gram-negative bacteria, this resistance is associated with the identity of their AcrB transporter protein sequence with the sequence of the AcrB protein from E. coli. SkQ1 is expelled from E. coli cells by the AcrAB-TolC multidrug efflux pump. In this study, we demonstrate that SkQ1 resistance in E. coli, in contrast to chloramphenicol resistance, does not depend on the presence of the multidrug efflux pump accessory protein AcrZ.
职业培训课程体系优化建设研究与实践--采油工程专业为例
Authors: 车 太杰
Published: January 2020

在职业培训中不断优化课程结构,从分析采油工程专业定向生的特点入手,构建模块式课程体系,突出技能,强化应用,培训效果显著提高,对其他岗位操作人员培训质量的提高具有参考作用。
Potencial fisiológico de sementes de cultivares de aveia branca produzidas em diferentes locais de cultivo
Authors: Gomes Diogo , Sapucay Moryb Lima da Costa , Passador Ailton Luiz , Bazzo José Henrique Bizzarri , Costa Denis Santiago da , Zucareli Claudemir
Published: January 2020

As condições edafoclimáticas do ambiente de cultivo influenciam diretamente o crescimento e o desenvolvimento da planta e, consequentemente, a produtividade e a qualidade das sementes. Neste sentido, objetivou-se avaliar o potencial fisiológico de sementes de aveia branca granífera produzidas em ambientes com diferentes características edafoclimáticas. O delineamento experimental foi o inteiramente casualizado em esquema fatorial 3 x 8, com quatro repetições. Os tratamentos constaram de três ambientes de cultivo no estado do Paraná (Londrina, Mauá da Serra e Ponta Grossa) e oito cultivares (IPR Afrodite, IPR Artemis, URS Taura, URS Tarimba, URS Charrua, URS Corona, URS Guará e URS Altiva). Foram avaliados: germinação, primeira contagem da germinação, comprimento e massa seca de plântula, índice de velocidade de emergência, emergência de plântulas em areia, envelhecimento acelerado e condutividade elétrica. Londrina, Ponta Grossa e Mauá da Serra apresentam potencial para a produção de sementes de aveia branca granífera, resultando em sementes com germinação acima dos padrões de comercialização da espécie. O cultivo em Londrina resulta na produção de sementes de elevado vigor para todas as cultivares analisadas. Já em Ponta Grossa, as sementes de melhor qualidade foram produzidas pelas cultivares URS Taura, URS Corona e URS Guará, e em Mauá da Serra pela cultivar URS Altiva.
Complex formation of modified chitosan and carboxymethyl cellulose and its effect on paper properties
Authors: FATEHI PEDRAM , QIAN LIYING , KITITERAKUN RATTANA , RIRKSOMBOON THIRASAK , XIAO HUINING
Published: January 2020

The application of an oppositely charged dual polymer system is a promising approach to enhance paper strength. In this work, modified chitosan (MCN), a cationic polymer, and carboxymethyl cellulose (CMC), an anionic polymer, were used sequentially to improve paper strength. The adsorption of MCN on cellulose fibers was analyzed via polyelectrolyte titration. The formation of MCN/CMC complex in water and the deposition of this complex on silicon wafers were investigated by means of atomic force microscope and quasi-elastic light scattering techniques. The results showed that paper strength was enhanced slightly with a layer-by-layer assembly of the polymers. However, if the washing stage, which was required for layer-by-layer assembly, was eliminated, the MCN/CMC complex was deposited on fibers more efficiently, and the paper strength was improved more significantly. The significant improvement was attributed to the extra development of fiber bonding, confirmed further by scanning electron microscope observation of the bonding area of fibers treated with or without washing. However, the brightness of papers was somewhat decreased by the deposition of the complex on fibers. Higher paper strength also was achieved using rapid drying rather than air drying.
EVALUASI STRATEGI BERSAING DIFFERENSIASI PT TERMINAL TELUK LAMONG PADA PELAYANAN BONGKAR MUAT PETIKEMAS: STUDI BANDING ANTAR TERMINAL PETIKEMAS DI LINGKUNGAN PELABUHAN TANJUNG PERAK
Authors: Budiman Arief , Tjahjadi Bambang
Published: January 2020

Peranan usaha dibidang peti kemas (bongkar muat) memberikan dampak positif bagi indutri lain terkait dengan kegiatan yang bisa mengatur, menata dan mengembangkan kegiatan logistik dan pendistribusian barang. Fungsi pelabuhan yaitu sebagai solusi terbaik untuk mengurangi kepadatan dan mempercepat proses distribusi barang.

            Tujuan dari penelitian ini adalah mengevaluasi penerapan strategi bersaing differensiasi PT Terminal Teluk Lamong di Lingkungan Pelabuhan Tanjung Perak yang diterapkan selama ini dan memberikan rekomendasi atas penerapan strategi bersaingdifferensiasiPT Terminal Teluk Lamong dalam rangka meningkatkan pelayanan jasa peti kemas di Lingkungan Pelabuhan Tanjung Perak. Penelitian ini menggunakan pendekatan kualitatif dengan pendekatan studi kasus. Sampel dari penelitian ini yaitu key informan dengan menggunakan purposive sampling serta melakukan wawancara.

            Hasil penelitian ini yaitu penerapan strategi PT Terminal Teluk Lamong dapat menunjang peningkatan kinerja bongkar muat petikemasdengan pemanfaatan high technology system, konsep Go Green Portserta didukung sumber daya manusia yang disiapkan untuk menunjang setiap perubahan yang dilakukan perusahaan. Rekomendasi yang diberikan yaitu konsisten mempertahankan konsep strategi Go GreenPort, terus berinovasi dengan fokus memberikan pelayanan prima kepada pelanggan.
Pengaruh Program K3 Terhadap Produktivitas Kerja pada Operator Alat Berat di PT BJTI Kota Surabaya
Authors: Ayu Friska , Karya Denis Fidita , Rhomadhoni Muslikha Nourma
Published: January 2020

More than 2 million people/years died due to work accidents and occupational disease (ILO, 2010), while at Indonesia showed every 7 second work accident was occurs. BJTI Port is a port service provider company that carries out activities as a port terminal operator. Heavy equip- ment operator is one of the high-risk jobs, therefore this company must arrange work program that support the occupational health and safety management implementation at workplace through Safety Culture Implementation. Analyze Influence Occupational Health and Safety Program to Productiv- ity of Work to Heavy Equipment Worker at PT Berlian Jasa Terminal Indonesia Surabaya is the aim of this research. Total samples of 52 workers, taken by the total sampling method. Data related to respondent characteristics like productivity of worker and OHS Program obtained from direct observation to the field and interviews with all workers. The research results showed that as many as heavy equipment operators (55,7%) had high productivity. The statistical test using ordinal regression test indicate that there is an influence between the OHS Program with Productivity of Work to Heavy Equipment Operator at BJTI Port (0,000<0,05). Implementation of OHS Program at BJTI Port was good and need to be maintained, if possible, it can be improved by increasing the competency of OHS Supervisors and OHS management accordance with OHS regulations. In addi- tion its necessary to conduct surveillance of OHS devices, especially in areas that are rarely tra- versed by OHS supervisor.
Optimal Design of Reinforced Concrete Cantilever Retaining Walls Utilizing Eleven Meta-Heuristic Algorithms: A Comparative Study
Authors: Kaveh Ali , Biabani Hamedani Kiarash , Bakhshpoori Taha
Published: January 2020

In this paper, optimum design of reinforced concrete cantilever retaining walls is performed under static and dynamic loading conditions utilizing eleven population-based meta-heuristic algorithms. These algorithms consist of Artificial Bee Colony algorithm, Big Bang-Big Crunch algorithm, Teaching-Learning-Based Optimization algorithm, Imperialist Competitive Algorithm, Cuckoo Search algorithm, Charged System Search algorithm, Ray Optimization algorithm, Tug of War Optimization algorithm, Water Evaporation Optimization algorithm, Vibrating Particles System algorithm, and Cyclical Parthenogenesis Algorithm. Two well-known methods consisting of the Rankine and Coulomb methods are used to determine lateral earth pressures acting on cantilever retaining wall under static loading condition. In addition, Mononobe-Okabe method is employed for dynamic loading condition. The design is based on ACI 318-05 and the goal of optimization is to minimize the cost function of the cantilever retaining wall. The performance of the utilized algorithms is investigated through an optimization example of cantilever retaining wall. In addition, convergence histories of the algorithms are provided for better understanding of their performance.
Peran Program Rojhek Cingur Radio Nada Fm Dalam Melestarikan Budaya Lokal Di Sumenep Madura
Authors: Zein Khoiruz , Indra Dewi Sulih
Published: January 2020

The Rojhek Cingur program was one of the Nada FM radio broadcast programs produced and broadcasted for the first time in 2016. The program discussed the values ​​and local culture of Madura delivered by the people, which was then combined with the news of cultural issues developing across the people. This research used descriptive qualitative type. The main informant of the study were the broadcaster of the Rojhek Cingur program and the Nada FM radio station manager. The data collection technique of this research was carried out by interview, documentation and observation. While the data analysis technique consisted of data collection, data reduction and data presentation. The data validation used data triangulation. The result showed that the Rojhek Cingur program was one of the Nada FM radio programs discussed cultural values. The role of Rojhek Cingur Nada FM radio program were (1) Rojhek Cingur was a rehabilitation of Madura culture, (2) Rojhek Cingur was an education and cultural socialization, and (3) Rojhek Cingur was an unifying media. The pattern of communication between broadcaster and Rojhek Cingur program listeners were (1) Two-way communication patterns (two way traffic communicatios), and (2) Multi-directional communication patterns.

 

Keywords: Mass Communication, Rujak Cingur program, Local Culture.
Strategi Komunikasi Pemasaran Dalam Meningkatkan Hasil Penjualan Di Kampung Keramik Dinoyo Kota Malang
Authors: Maryanto Tarno , Rakhim Syahida Amanah
Published: January 2020

A good and effective marketing communication strategy is very important to improve the production and sales targets in Kampung Keramik, Kelurahan Dinoyo, Malang. This research examined how marketing communication strategies increase sales and improve good relations with customers and prospective customers. The purpose of this study was to find out and learn marketing communication strategies to maintain good relationships with customers and prospective customers. This study used a descriptive qualitative, with the data collection technique through in-depth interviews, field observations involving informants and documentation as the main data sources. The results of this study indicated that the marketing communication strategy adopted by Kampung Keramik Dinoyo in increasing sales and maintaining relationships with customers and prospective customers was by conducting market selection strategies, product knowledge strategies, distribution strategies and promotion strategies. In conducting promotional activities to increase the sales in Kampung Keramik Dinoyo by putting advertisments in YouTube channel, Instagram, Facebook, online media and websites. Kampung Keramik Dinoyo also conducted a Direct Marketing and Online Marketing Programs that aimed to expand information networks to attract prospective customers and established good relations with their customers.

 

Keywords: Marketing Communication, Sales, Customers, Dinoyo Ceramics.
Korelasi antara Penguasaan Kosakata dengan Kemampuan Menulis Karangan Narasi pada Pelajaran Bahasa Indonesia Siswa Kelas XI SMA Negeri 4 Bengkulu
Authors: Kusmaita Kusmaita
Published: January 2020

Not all of the ability to write narrative essays from Bengkulu 4 High School students still obtained good criteria. This is thought to be caused by the low mastery of the vocabulary. For this reason, testing of the correlation between vocabulary mastery and narrative essay writing skills is needed. The purpose of this study is to: 1) describe the level of mastery of Indonesian vocabulary, 2) describe the level of narrative essay writing ability, and 3) determine whether there is a significant relationship between mastery of vocabulary mastery with narrative essay writing ability. The research method uses the correlation method. Data collection techniques using technical tests. The test instrument trial then the validity and reliability are calculated. Correlation analysis using the Product Moment formula. The results showed that there was a positive correlation between vocabulary mastery and narrative essay writing ability with a value of 0.724. This is also proved by mastering students 'vocabulary sufficiently and vice versa the results of students' narrative essay writing ability are also categorized sufficiently. This proves that the better the students' vocabulary mastery, the better the ability to write narrative essays.
ElectrodeLess FerriteFree ClosedLoop InductivelyCoupled Fluorescent Lamp
Authors: Popov Oleg A. , Starshinov Pavel V. , Vasina Victoriya N.
Published: January 2020

Electrode-less ferrite-free inductivelycoupled low pressure discharge was excited in the mixture of mercury vapour (~10–2 Torr) and argon (0.1 Torr) at a frequency of 2.0 MHz and lamp RF powers of (150–202) W with the help of a 6turn induction coil. The discharge lamp of rectangular shape (50 cm in length and 7 cm in height) employed a closed-loop glass tube of 30 mm in diam. Tube walls inner surface was coated with three-color phosphor (Тcc = 3100 K, Ra = 80). The induction coil made from silver-coated copper wire (ρw = 2.2x10–3 Ohm/cm) was disposed on the atmospheric side of tube walls, along closed-loop lamp tube perimeter. As plasma power, Ppl, grew from 127W to 180 W, coil power losses practically were unchanged, Pcoil = (25–22) W. Lamp luminous flux, Фv, grew with plasma power from 10430 lm (Ppl =127 W) to 13500 lm (Ppl =180 W), while plasma efficacy, ηpl = Фv/Ppl, decreased from 82 to 75 lm/W, and lamp efficacy ηV = Фv/(Ppl + Pcoil) decreased from 70 to 67 lm/W.
The Implication of AMPA Receptor in Synaptic Plasticity Impairment and Intellectual Disability in Fragile X Syndrome
Authors: CHENG G.-R. , LI X.-Y. , XIANG Y.-D. , LIU D. , MCCLINTOCK S. M. , ZENG Y.
Published: January 2020

Fragile X syndrome (FXS) is the most frequently inherited form of intellectual disability and prevalent single-gene cause of autism. A priority of FXS research is to determine the molecular mechanisms underlying the cognitive and social functioning impairments in humans and the FXS mouse model. Glutamate ionotropic alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors (AMPARs) mediate a majority of fast excitatory neurotransmission in the central nervous system and are critically important for nearly all aspects of brain function, including neuronal development, synaptic plasticity, and learning and memory. Both preclinical and clinical studies have indicated that expression, trafficking, and functions of AMPARs are altered and result in altered synapse development and plasticity, cognitive impairment, and poor mental health in FXS. In this review, we discuss the contribution of AMPARs to disorders of FXS by highlighting recent research advances with a specific focus on change in AMPARs expression, trafficking, and dependent synaptic plasticity. Since changes in synaptic strength underlie the basis of learning, development, and disease, we suggest that the current knowledge base of AMPARs has reached a unique point to permit a comprehensive re-evaluation of their roles in FXS.
PENGEMBANGAN KEMAMPUAN KOMUNIKASI MATEMATIK SISWA SMP PENGEMBANGAN KEMAMPUAN KOMUNIKASI MATEMATIK DENGAN MEAs (Developing Mathematical Communication Skills For Junior High School Students)
Authors: Wahyuningrum Endang
Published: January 2020

Communication ability on mathematics should be mastered by students to involve in mathematical learning process. This ability would help students in learning mathematics. Srategy of Model Eliciting Activities (MEAs) can be used to develop mathematical communication ability. This study examines mathematical communication ability of students after going through the learning process with a MEAs strategy. This Quasi-static research with comparison group design involved 69 eight-grade students. The students were from secondary school in Depok. The data were analized by using average differential test and ANOVA two pathways. Generally, the data shows that mathematical communication ability of students engaged in learning with MEAs strategy were better than the students engaged in conventional.

 

Kemampuan komunikasi matematik merupakan kemampuan yang harus dimiliki siswa untuk dapat terlibat secara maksimal dalam proses pembelajaran matematika. Kemampuan ini bermanfaat bagi siswa untuk membangun pemahaman dan pengetahuan konsep matematik. Srategi pembelajaran Model Eliciting Activities (MEAs) dapat digunakan guru untuk mengembangkan kemampuan komuniksai matematik siswa. Tulisan ini melaporkan hasil penelitian tentang kemampuan komunikasi siswa setelah terlibat dalam proses pembelajaran matematika dengan strategi MEAs. Penelitian dengan rancangan Quasi-static ini melibatkan 69 siswa SMP kelas 8 yang terbagi dalam dua kelompok. Kelompok eksperimen terdiri dari 34 siswa dan kelompok kontrol terdiri dari 35 siswa. Data hasil penelitian dianalisis menggunakan uji beda rata-rata dan uji ANOVA dua jalur. Secara umum, penelitian menunjukkan bahwa kemampuan komunikasi matematik siswa yang mendapatkan pembelajaran dengan strategi MEAs lebih baik dari kemampuan komunikasi matematik siswa yang mendapatkan pembelajaran konvensional.