bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of serum HE4 levels in various histologic subtypes of epithelial ovarian cancer and other malignant tumors
Authors: Blackman Alexandra , Mitchell Jessica , Rowswell-Turner Rachael , Singh Rakesh , Kim Kyu Kwang , Eklund Elizabeth , Skates Steven , Bast Robert C. , Messerlian Geralyn , Miller M. Craig , Moore Richard G.
Published: December 2021

BACKGROUND:

The measurement of serum HE4 levels has emerged as a sensitive and specific biomarker for epithelial ovarian cancers (EOCs). However, serum levels in women diagnosed with various histologic subtypes of EOC and in women with metastatic non-ovarian primary malignancies have not been widely reported.

OBJECTIVE:

The goal of this study was to identify how serum HE4 levels vary in women diagnosed with different histologic subtypes of EOC and non-ovarian malignancies.

METHODS:

Data from six prospective pelvic mass clinical trials was combined and an evaluation of serum HE4 levels in women diagnosed with a malignancy was performed. For all patients, serum was obtained prior to surgery and final pathology, including primary tumor site, histologic subtype, grade and stage, were recorded. The mean, median, standard deviation, maximum, and minimum HE4 levels were determined for each group.

RESULTS:

A total of 984 patients were included in this study, with the average patient age being 60 years old. There were 230 premenopausal and 754 postmenopausal patients. Serum HE4 levels were elevated (≥70.0 pMol) in 85%of EOCs, 40%of LMP tumors, 21%of non-EOCs (germ cell tumors), 25%of cervical cancers, and 47%of non-gynecologic metastatic cancers. Analysis of histologic subtypes revealed 90%( n = 391) of serous, 85%( n = 73) of endometrioid, 45%( n = 42) of mucinous, 86%( n = 51) of mixed tumors, and 69%( n = 36) of clear cell tumors had elevated serum HE4 levels.

CONCLUSIONS:

Serum HE4 levels are most often elevated in women with high grade serous and endometrioid EOCs, and though serum elevations are seen more often with advanced stage disease, HE4 is also often elevated in early stage disease and lower grade tumors.
A coronary artery CTA segmentation approach based on deep learning
Authors: Huang Caiyun , Yin Changhua
Published: December 2021

Presence of plaque and coronary artery stenosis are the main causes of coronary heart disease. Detection of plaque and coronary artery segmentation have become the first choice in detecting coronary artery disease. The purpose of this study is to investigate a new method for plaque detection and automatic segmentation and diagnosis of coronary arteries and to test its feasibility of applying to clinical medical image diagnosis. A multi-model fusion coronary CT angiography (CTA) vessel segmentation method is proposed based on deep learning. The method includes three network layer models namely, an original 3-dimensional full convolutional network (3D FCN) and two networks that embed the attention gating (AG) model in the original 3D FCN. Then, the prediction results of the three networks are merged by using the majority voting algorithm and thus the final prediction result of the networks is obtained. In the post-processing stage, the level set function is used to further iteratively optimize the results of network fusion prediction. The JI (Jaccard index) and DSC (Dice similarity coefficient) scores are calculated to evaluate accuracy of blood vessel segmentations. Applying to a CTA dataset of 20 patients, accuracy of coronary blood vessel segmentation using FCN, FCN-AG1, FCN-AG2 network and the fusion method are tested. The average values of JI and DSC of using the first three networks are (0.7962, 0.8843), (0.8154, 0.8966) and (0.8119, 0.8936), respectively. When using new fusion method, average JI and DSC of segmentation results increase to (0.8214, 0.9005), which are better than the best result of using FCN, FCN-AG1 and FCN-AG2 model independently.
Dysphonia: state-of-the-art and treatment tools
Authors:   Central Research Institute of Epidemiology of the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russian Federation, Nikolaeva S.V. , Turovskiy A.B. ,   V.V. Veresaev City Clinical Hospital No. 81, Moscow, Russian Federation, Khlypovka Yu.N. ,   Central Research Institute of Epidemiology of the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russian Federation,   Central Clinical Hospital and Polyclinic of the Department for Presidential Affairs, Moscow, Russian Federation
Published: December 2021

Dysphonia is a voice disorder manifesting with hoarseness, nasality, weak voice, and vocal fatigue. Being a common complaint, dysphonia is a common cause of medical referral and disability due to absence from work. Voice disorders affect individuals of any age. Meanwhile, voice disorders are more commonly reported in patients over 65 years (29.1%) and children. Moreover, 23.4% of children may have dysphonia at a certain point — this disorder is more common in boys than in girls. There are numerous causes of dysphonia, e.g., head snd neck tumors, neurological, gastrointestinal, or lung diseases, psychological disorders, injuries, iatrogenic injuries, infections, etc. Meanwhile, acute laryngitis, a symptom of acute respiratory infections, is one of the leading causes of dysphonia. The most common causative agents of acute laryngitis are parainfluenza and influenza viruses, adenoviruses, on occasion, respiratory syncytial virus, and viral-bacterial associations. Dysphonia treatment should be complex and include systemic and topical corticosteroids, antihistamines, mucoactive medications, systemic and topical antibiotics, and combined medications (e.g., Homeovox). Clinical trials have demonstrated their efficacy in adults and children. KEYWORDS: acute laryngitis, dysphonia, hoarseness, treatment. FOR CITATION: Nikolaeva S.V., Turovskiy A.B., Khlypovka Yu.N. Dysphonia: state-of-the-art and treatment tools. Russian Medical Inquiry. 2021;5(11):749–754 (in Russ.). DOI: 10.32364/2587-6821-2021-5-11-749-754.
The rational treatment approach to infectious inflammatory diseases of the upper respiratory airways in children
Authors:   Federal Research Center for Nutrition & Biotechnology, Moscow, Russian Federation, Mukhortykh V.A.
Published: December 2021

Infectious inflammatory diseases of the upper respiratory airways are the most common among respiratory disorders. Issues in the management of infectious inflammation in upper airway mucosa are the diversity of infective agents, generation of biofilms, suppression of normal microflora, the lack of accurate and rapid laboratory tests for the analysis of the microbiota of upper airway mucosa, the risk of superinfection and complications after treatment with chemical antiseptics and antibacterial drugs. All these factors underscore the need for a more careful and rational approach to selecting therapy for the upper respiratory airways’ infectious inflammatory diseases, particularly preparations that preserve human microflora (a factor of mucosal immunity) and are characterized by a broad spectrum of activity on various pathogens. In addition, the human organism produces a variety of antimicrobial factors that relieve the burden of colonizing microbes. One of these antimicrobial factors, lysozyme, is a natural antiseptic found in high concentrations in fluids on mucosal surfaces. The results of clinical and laboratory studies have proven the effectiveness of lysozyme-containing drugs, which increases the prospects for their wider application in pediatric practice. KEYWORDS: lysozyme, pyridoxine, bacteria, viruses, respiratory infections, biofilms, tonsillopharyngitis, microbiome. FOR CITATION: Mukhortykh V.A. The rational treatment approach to infectious inflammatory diseases of the upper respiratory airways in children. Russian Medical Inquiry. 2021;5(11):755–761 (in Russ.). DOI: 10.32364/2587-6821-2021-5-11-755-761.
Respiratory viral infections in children: modalities for pathogenic treatment
Authors:   Central Research Institute of Epidemiology of the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russian Federation, Nikolaeva S.V. , Khlypovka Yu.N. ,   Central Research Institute of Epidemiology of the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russian Federation, Zavolozhin V.A. ,   Central Research Institute of Epidemiology of the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russian Federation, Shushakova E.K. ,   Central Research Institute of Epidemiology of the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russian Federation, Gorelov A.V. ,   Central Research Institute of Epidemiology of the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russian Federation,   A.I. Yevdokimov Moscow State University of Medicine and Dentistry,Moscow, Russian Federation
Published: December 2021

Respiratory viruses are the leading cause of pediatric morbidity and mortality worldwide. Rapid identification of a pathogen, epidemiological surveillance, description of symptoms, and the development of preventive and therapeutic measures are keystones to limit the spread of respiratory infections. Novel viruses with specific properties are regularly discovered. This paper addresses essential data on the most common viruses provoking acute respiratory infections, including whose in children and the pattern of their course. Conventionally, the most vital concern is flu. Influenza viruses provoke seasonal outbreaks, epidemics, and pandemics. Many studies demonstrate the role of rhinovirus C in the development of bronchiolitis and, subsequently, asthma. Severe acute respiratory syndrome-related coronavirus (SARS-CoV), Middle East respiratory syndrome-related coronavirus (MERS-CoV), and SARS-CoV-2 provoking COVID-19 were recently described. Knowledge of known and newly emerging viruses is crucial for timely adequate medical care. The authors discuss major therapeutic strategies for acute respiratory infections that provide a more favorable course of infectious inflammation irrespective of viral etiology. KEYWORDS: acute respiratory infections, influenza virus, rhinovirus, coronavirus, pneumonia, interferon. FOR CITATION: Nikolaeva S.V., Khlypovka Yu.N., Zavolozhin V.A. et al. Respiratory viral infections in children: modalities for pathogenic treatment. Russian Medical Inquiry. 2021;5(11):762–767 (in Russ.). DOI: 10.32364/2587-6821-2021-5-11-762-767.
Case series of secondary thrombotic microangiopathy in children with multisystem inflammatory syndrome associated with COVID-19
Authors:   Khimki Regional Hospital, Khimki, Russian Federation, Novikov D.V. , Sabinina T.S. ,   Khimki Regional Hospital, Khimki, Russian Federation, Shalbarova T.V. ,   Central Research Institute of Epidemiology of the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russian Federation, Chugunova O.L. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Melekhina E.V. ,   Central Research Institute of Epidemiology of the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russian Federation
Published: December 2021

Thrombotic microangiopathy (TMA) is one of the main links in the pathogenesis of multisystem inflammatory syndrome in children (MIS-C) associated with a new coronavirus infection caused by SARS-Cov-2 (COVID-19). In the setting of an increasing number of patients with hemolytic uremic syndrome (HUS) during the COVID-19 pandemic, 5 out of 7 cases of HUS (according to the Khimki Regional Hospital) in children revealed the association between acute kidney injury (AKI) and history of COVID-19. Also, there were recorded laboratory markers of systemic inflammation, the relevant criteria for the diagnosis of MIS-C associated with SARS-CoV-2. The article presents a clinical analysis of the case series concerning HUS, during which a comparison with the world literature data was conducted. It was proposed to consider this pathology in children as secondary thrombotic microangiopathy (TMA) in the setting of new coronavirus infection, similar to secondary TMA, developed due to exposure to HIV. During the COVID-19 pandemic, it is extremely important to establish the association between the TMA and the experienced COVID-19 in children for the therapy correction and further follow-up of patients after discharge from the hospital. KEYWORDS: new coronavirus infection, SARS-CoV-2, COVID-19, multisystem inflammatory syndrome, secondary thrombotic microangiopathy, hemolytic-uremic syndrome, acute kidney injury. FOR CITATION: Novikov D.V., Sabinina T.S., Shalbarova T.V. et al. Case series of secondary thrombotic microangiopathy in children with multisystem inflammatory syndrome associated with COVID-19. Russian Medical Inquiry. 2021;5(11):773–777 (in Russ.). DOI: 10.32364/2587-6821-2021-5-11-773-777.
Evaluation of rapid, cassette immunochromatographic tests in the serological diagnosis of COVID-19
Authors: Rastawicki Waldemar , Płaza Klaudia , Pietrusiński Adam
Published: December 2021

Introduction: Lateral flow assays (LFIA) are the technology behind low-cost, simple, rapid and portable detection devices popular in biomedicine. Lately, they are very common used in serodiagnosis of SARS-CoV-2 infections. The aim of the presented study was to assess the usefulness of selected LFIA in serological diagnosis of COVID-19.
Methods: The usefulness of seven lateral flow assays in the serodiagnosis of COVID-19 was evaluated (VAZYME, DIAGNOSIS, PCL, INGEZIM, BIOSENSOR, ACCU-TELL, NOVAtest). The study used 107 serum samples obtained from 74 individuals with current SARS-CoV-2 infection confirmed by RT-PCR. The ELISA-IgG (Euroimmun) was used as the reference assay for sensitivity and specificity testing.
Results: The highest percentage of positive results was obtained when searching for IgG antibodies with the NOVAtest (40.6%) and DIAGNOSIS (39.2%) sets and the lowest detection for the PCL set - 25.5%. In the case of searching for IgM antibodies in all sets, significantly lower percentages of positive results compared to the IgG class were recorded. In general, all lateral flow assays showed low sensitivity in relation to the Euroimmun ELISA-IgG. The DIAGNOSIS kit (64.5%) was characterized by the highest sensitivity, and the PCL kit was the lowest (38.7%). On the other hand, the specificity of all kits was very high, almost 100% in almost all cases.
Conclusions: Lateral flow assays due to their low sensitivity are not suitable for quick diagnosis of the current SARS-CoV-2 infections and cannot be an alternative to genetic or even antigen tests. They may be used only to retrospectively test the presence of IgG antibodies. However, a negative results of LFIA in suspected disease or after vaccination should be confirmed by more sensitive serological tests.
Human gut microbiota – its diversity and impact on our health
Authors: Wardak Sebastian
Published: December 2021

The human digestive tract is the living environment for billions of cells of various microorganisms that are part of the human microflora. The use of modern molecular biology techniques, such as NGS (Next Generation Sequencing), made it possible to study the microorganisms inhabiting the intestines and to understand their impact on human health. The gut microbiota plays a significant role in the synthesis and metabolism of many nutrients and metabolites, including short-chain fatty acids (SCFA), amino acids, lipids, bile acids and vitamins. Many factors such as diet, age, climate, and socioeconomic conditions influence the diversity of the microbiota. Rapid changes in the composition of the microbiota (disturbance of homeostasis) can lead to dysbiosis - a condition associated not only with intestinal disorders, but also with numerous extraintestinal diseases. The present work is a review of current reports on: research techniques used to analyze microbiota, the impact of various factors on its diversity and the impact of microbiota on our health.
Audiovisual practices of new media and their communicative nature
Authors: Tormakhova Anastasiia
Published: December 2021

The purpose of the article is to analyze the specifics of audiovisual practices of new media and reveal their communicative nature. The methodology of the work is to involve an analytical approach to highlight the features of new media and their components. A comparative approach was used to highlight the features of audiovisual practices and media art. Scientific Novelty. The specifics of audiovisual practices of new media, which are characterized by interactivity, are revealed. Their role in communication through audiovisual content is emphasized. Simplifying the mechanisms for creating an audiovisual product in software applications makes it easy to distribute messages. In contrast to media art, which has a clear aesthetic function, in audiovisual practices prevail communicatively. Conclusions. New media occupy a significant place in the modern cultural space. A wide range of phenomena that can be attributed to new media is characterized by certain common features. These include their communicative nature and existence on the Internet. Audiovisual practices of new media are extremely diverse. They include both media art and practices that contain an aesthetic component but cannot be fully attributed to the arts. The art practices of new media are evolving through a combination of birth digital and became digital objects. Communication and interactivity are the basic characteristics of new media audiovisual practices.
The role of art tourism in the process of forming tourist attractiveness of the territory
Authors: Plyuta Olena
Published: December 2021

The purpose of the article is to determine the role of modern art tourism, its components, and varieties in the process of the formation of tourist attractiveness of a certain territory. The methodology of the research is based on the use of general scientific methods (systemic, structural and functional, genetic, typologization, etc.) with the involvement of research guidelines of socio-cultural analysis of phenomena and processes. The scientific novelty of the results obtained is to find out the role of art tourism in the process of forming a tourist attractiveness of the territory, which consists in the formation of a positive image of the latter due to the use of new methods and mechanisms for promotion. Conclusions. The article presents an article characteristic of art tourism, which provides intellectual rest, that is, a combination of pleasant with useful, namely purposeful visits to various art measures and events: forums of contemporary art, large artistic and photo exhibitions, theatrical prime minister, film festivals, etc. Art tourism creates positive characteristics of a particular territory, forms a certain image of a consumer about cultural and historical heritage, contemporary art, everyday style of life, etc. The features of modern street art, which is one of the directions attracting tourists from all over the world. Street art is able to tell an entire history of culture and life without a single word. More and more communities include Street Art and Graffiti in the concept of designing modern quarters and areas of their cities. Important attention is paid to this direction of creative tourism activity as an art hotel, which distinguished from the overall mass with its originality, artistic design, and creative approach to service.
Ideological and artistic factors of the revival of national culture in the crisis periods of 1917-1930 and the end of the 1950s - the beginning of the 1970s.
Authors: Shevchenko Mуroslava
Published: December 2021

The purpose of the article is to study the ideological and artistic factors of the revival of national culture in the crisis periods of 1917-1930 and late 1950's - the early 1970s, analysis of common intentions and creative achievements in creating new dogmas of Ukrainian culture, the impact of political processes on culture and art. The methodology is based on the analytical method, which consists of the study of historical, art, and cultural sources. Cultural-historical - to consider the general state of Ukrainian fine arts of these periods, art history - provides an analysis of the phenomenon in an artistic context. The historical-comparative method, by comparison, makes it possible to identify commonalities and differences between historical processes and phenomena. The scientific novelty is to identify ideological and artistic factors in the revival of national culture in the crisis periods of 1917-1930's and late 1950's - early 1970's. Conclusion. The basic principles of ideological and artistic factors of the creation of national culture in the periods of 1917-1930 and the end of the 1950s - the beginning of the 1970s are revealed. The basic principles and methods of the revival of Ukrainian culture in the specified periods are analyzed.
Purchasers of artworks on the art market and their motivations
Authors: Akimov Dmytro
Published: December 2021

The purpose of the article. Research and analysis of marketing technology algorithms and study of motivations of purchasers of products of fine arts. The methodology is to apply comparative, empirical, and theoretical methods. This methodological approach allows us to analyze the motivations of purchasers of works of fine art and further research of marketing processes in the promotion of works of fine art in the art market. The scientific novelty consists in the expansion of ideas about the motivations of purchasers of works of fine art. The article explores the marketing processes in the art market. Algorithms of marketing technologies in the analysis of motivations of purchasers of works of fine arts are analyzed. That is, the article proves that in art marketing it is relevant and necessary to regularly study the algorithms of the behavior of purchasers of works of art, as well as in general - situations in which the collector decides on the purchase of works of art. Research in the field of art market marketing gives grounds to state that artistic creativity is a field of large and small business, which should deeply study and analyze the motivations of purchasers, involving specialists in psychology, sociology, economics. It should be noted that in the marketing of fine arts the technologies of studying and analyzing the motivations of the purchasers of works of art are purposefully and productively used. Conclusions. The article analyzes the models of acquisition of works of fine art. It is also proved that the behavior of the purchaser of works of art is determined by three mandatory components: Individual - Product - Situation, on which the model of consumption and consumer behavior is based. Thus, we have studied the individuals involved in the acquisition of works of art that are products on the market, presented in kind in museums or private collections. The success of art marketing depends not only on the personality of the artist who created the product presented on the market, not only on the solvency of the final purchaser of this product but also on the personality, creative and business qualities of dealers, distributors, and other intermediaries in the art market. At a certain stage, they also become purchasers of this product on the way from the artist to the final buyer - a museum or a private collector, etc. We also explored market algorithms for acquiring works of art in a collection.
The Great Pechersk Church’ Mural Paintings of the Late 19th Century as the Interpretation of Its Old Russian Image
Authors: Bardik Maryna
Published: December 2021

The purpose of the article is to discover the mural paintings of the Great Pechersk Church as the version of theology and academic sacred mural painting of the late 19th century. The research methodology is based on complex using historical and cultural analysis, art study analysis, and biographical method. Scientific novelty. It is determined that the process of creating the Old Russian image in the Great Pechersk Church (the Dormition Cathedral) began in 1880.  The photo of the drawing of the ancient part of the Church made by the order of A. Prakhov in 1893, has been introduced into scientific circulation. The author studied the painting decoration as a synthesis of the academic theological thought and academic sacred mural painting, discovered its implementation in choosing topics, plots, and placement of compositions. The author gave a characteristic of the source corps on the paintings from the collection of the National Preserve “Kyiv-Pechersk Lavra”. The author researched the transformation of painting preliminary design and Byzantine Canon of the 11–12th centuries on behalf of the Holy Mother of God theme and observed the connection of the composition “Ascension of Panagia” on the tradition of monastic life in the Kyiv-Pechersk Lavra. The topical and plotlines have been improved namely Christianize Old Russian is determined by one more leading topic. Conclusions. The process of creating a new mural painting in the Great Pechersk Church began still yet 1880. The detection of the ancient part of the Church contributed to the change in its painting decoration. This change was the result of the academic theological program implemented by means of academic sacred mural painting. The tradition of previous painting decoration preserved in the preliminary design end reflected one of the traditions of monastic life in the Kyiv-Pechersk Lavra. The witness in Pechersk Paterikon of the compositions in the Great Church has been implemented in mural paintings. However, the academic theological opinion of the late 19th century was subordinated to the canon of 11–12th centuries not complete. The theme of the introduction of Christianity was presented in mural painting as one of the leading topics.
The Effect of High-Intensity Interval Training on GLP-1, Appetite, and Weight in Obese Rats
Authors: Sepehri Mohammad Hosein , Nemati Javad ,   Department of Sport Sciences, School of Education and Psychology, Shiraz University, Shiraz, Iran., Koushkie Jahromi Maryam ,   Department of Sport Sciences, School of Education and Psychology, Shiraz University, Shiraz, Iran., Eskandari Mohammad Hadi ,   Department of Food Science and Technology, School of Agriculture, Shiraz University, Shiraz, Iran, Daryanoosh Farhad ,   Department of Sport Sciences, School of Education and Psychology, Shiraz University, Shiraz, Iran.
Published: December 2021

Background and Objectives: Appetite is an essential factor in obesity. The present study aimed to evaluate the effect of High-Intensity Interval Training (HIIT) on GLP-1, appetite, and weight of obese mice while maintaining a high caloric diet. Subjects and Methods A total of 24 C57BL/6 mice with a Mean±SD weight of 20.7±1 g were selected. After implementing a high caloric dieting and making them fat (Mean±SD weight: 30.95±3.23 g), they were divided into two groups of training and control. A high caloric diet was maintained for both groups (training and control) until the end of the experiment, while the training group performed HIIT for 8 weeks. Every session of HIIT included 30 minutes of exercise with a progressive intensity of 50% to 60% in low-intensity intervals and 80% to 90% in high-intensity intervals. The independent t test and analysis of variance with repeated measures were used for data analysis. Results Findings of the study indicated that GLP-1 increased significantly in the HIIT training group compared to the control group (P<0.05). In the HIIT group, body weight was significantly higher (P<0.001), and food intake was significantly lower (P<0.001) than those in the control group. Conclusion When consuming high-calorie food, HIIT training can probably cause weight loss through reducing appetite mediated by increasing GLP-1
The Effect of Logotherapy on Death Anxity, Pain Catastrophizing, Pain Acceptance, and Pain Intensity in Patients With Prostate Cancer
Authors:   Department of Health Psychology, Khorramshahr-Persian Gulf International Branch, Islamic Ahvaz University, Khorramshahr, Iran, Haghdoost Mohammad Reza , Saraj Khoami Naser ,   Department of psychology ,Dezful Branch, Islamic Azad university, Dezful, Iran, Makvandi Behnam ,   Department of psychology ,,Ahvaz Branch,Islamic Azad University,Ahvaz , Iran
Published: December 2021

Background and Objectives: This study investigated the effectiveness of logotherapy on death anxiety, pain catastrophizing, pain acceptance, and severity of pain in prostate cancer patients. Subjects and Methods : The research design was an experimental pretest-posttest with a control group. At first, 40 hospitalized men in a treatment center were selected by using the purposive sampling method. The experimental group was treated for eight 45-minute sessions by training logotherapy. All subjects completed the questionnaire at the beginning of the study, immediately after the intervention, and one month after the treatment (one-month follow-up). For data analysis, 1-way analysis of variance was used. Results The results indicated that logotherapy in the experimental group was more effective than the control group in reducing death anxiety, pain catastrophizing, pain acceptance, and severity of pain in prostate cancer patients. The follow-up results also showed that the effect of logotherapy was sustained on death anxiety, pain catastrophizing, pain acceptance, and severity of pain in prostate cancer patients. Conclusion The results showed that Logotherapy has an effect on death anxiety, pain catastrophe, pain acceptance and pain intensity in patients with prostate cancer
Performance evaluation of various deployment scenarios of the 3-replicated Cassandra NoSQL cluster on AWS
Authors: Gorbenko Anatoliy , Karpenko Andrii , Tarasyuk Olga
Published: December 2021

A concept of distributed replicated NoSQL data storages Cassandra-like, HBase, MongoDB has been proposed to effectively manage Big Data set whose volume, velocity and variability are difficult to deal with by using the traditional Relational Database Management Systems. Tradeoffs between consistency, availability, partition tolerance and latency is intrinsic to such systems. Although relations between these properties have been previously identified by the well-known CAP and PACELC theorems in qualitative terms, it is still necessary to quantify how different consistency settings, deployment patterns and other properties affect system performance.This experience report analysis performance of the Cassandra NoSQL database cluster and studies the tradeoff between data consistency guaranties and performance in distributed data storages. The primary focus is on investigating the quantitative interplay between Cassandra response time, throughput and its consistency settings considering different single- and multi-region deployment scenarios. The study uses the YCSB benchmarking framework and reports the results of the read and write performance tests of the three-replicated Cassandra cluster deployed in the Amazon AWS. In this paper, we also put forward a notation which can be used to formally describe distributed deployment of Cassandra cluster and its nodes relative to each other and to a client application. We present quantitative results showing how different consistency settings and deployment patterns affect Cassandra performance under different workloads. In particular, our experiments show that strong consistency costs up to 22 % of performance in case of the centralized Cassandra cluster deployment and can cause a 600 % increase in the read/write requests if Cassandra replicas and its clients are globally distributed across different AWS Regions.
Data pre-processing to increase the quality of optical text recognition systems
Authors: Dergachov Konstantin , Krasnov Leonid , Bilozerskyi Vladislav , Zymovin Anatoly
Published: December 2021

The subject of study in the article is the formulation of a modern concept of improving the quality of work of optical recognition systems by using a set of various algorithms for preprocessing document images at the user's discretion. The research synthesizes algorithms that compensate for external negative influences (unfavorable geometric factor, poor lighting conditions when photographing, the effect of noise, etc.). The methods used imply a certain sequence of data preprocessing stages: geometric transformation of the original images, their processing with a set of various filters, image equalization without increasing the noise level to increase the contrast of images, the binarization of images with adaptive conversion thresholds to eliminate the influence of uneven photo illumination. The following results were obtained. A package of algorithms for preliminary processing of photographs of documentation has been created, in which, to increase the functionality of data identification, a face detection algorithm is also built in, intended for their further recognition (face recognition). A number of service procedures are provided to ensure the convenience of data processing and their information protection. In particular, interactive procedures for text segmentation with the possibility of anonymizing its individual fragments are proposed. It helps provide the confidentiality of the processed documents. The structure of the listed algorithms is described and the stability of their operation under various conditions is investigated. Based on the results of the research, a text recognition software was developed using the Tesseract version 4.0 optical character recognition (OCR) program. The program "HQ Scanner" is written in Python using the OpenCV library. An original technique for evaluating the effectiveness of the algorithms using the criterion of the maximum probability of correct text recognition has been implemented in software. A large number of examples of system operation and software testing results are provided. Conclusions. The results of the research conducted are a basis for developing software for creating cost-effective and easy-to-use OCR systems for commercial use.
EL PÉNDULO Y EL PÁJARO: LA CENTRALIDAD DE LA METÁFORA EN EL TEATRO DE REMÓN
Authors: Rodríguez Alonso Mariángeles , Rodríguez Alonso María
Published: December 2021

El presente trabajo argumenta la centralidad de la metáfora en la dramaturgia de Remón en un doble sentido, escénico y poético. Metáfora en el sentido escénico, en tanto la puesta en escena que propone su dramaturgia se recrea en la distancia entre lo representante –actor, escenografía, etc.— y lo representado —ficción teatral—, subrayando la materialidad del primer plano mediante estrategias diegéticas y metateatrales; y metáfora poética en tanto el texto participa del salto del significar poético en el que un término figurado es empleado para decir con más precisión, con mayor intensidad el elemento real. Para ilustrar los procedimientos que vertebran su teatro, el artículo se detiene en el análisis de Cuarenta años de paz, (2015); Barbados (2017); y El autor y la incertidumbre (2020).
LA MECÁNICA EXPRESIONISTA Y LO TRAVESTI EN EL AMARILLO SOL DE TUS CABELLOS LARGOS
Authors: Eltit Fuentes Mayra
Published: December 2021

Este artículo es el resultado de una investigación en base a la obra teatral El amarillo sol de tus cabellos largos de la compañía La Niña Horrible. El análisis consiste en la filiación del expresionismo con la estética y la poética de la obra, fundamentando la existencia de una mecánica expresionista en el gesto corporal y vocal caracterizado por lo grotesco. A partir de la comprensión de esta mecánica, aparece lo pictórico como un procedimiento para componer, dirigir y crear, fuertemente ligado a la estética visual y relacionado también en algunos aspectos con el expresionismo. Finalmente, se ahondará en cómo lo travesti aúna los elementos de esta obra, presentándose como fondo y forma, respondiendo a la pregunta de investigación inicial por el cómo una mecánica expresionista permite expresar sin decaer en el formalismo.
PREFERENSI GENERASI MILENIAL DALAM MEMILIH PEMBAYARAN DIGITAL (STUDI KASUS PADA MAHASISWA DI JABODETABEK)
Authors: Sari Mia Andika , Aminah Indianik , Redyanita Hastuti
Published: December 2021

Kemajuan teknologi yang cukup pesat membawa dampak terhadap dunia keuangan khususnya transaksi pembayaran. Perkembangan ini ditandai dengan jumlah transaksi electronic money atau uang elektronik di Indonesia menunjukan data yang terus meningkat berdasarkan hasil statistik yang dikeluarkan oleh Bank Indonesia. Banyaknya perusahaan pembayaran digital ini memberi banyak pilihan kepada masyarakat dalam menentukkan alat pembayaran digital mana yang akan mereka gunakan. Penelitian ini bertujuan untuk menganalisa faktor-faktor Influencer Sosial Media, Brand Image Perusahaan, Promotional Benefit, Financial Technology Knowledge, Persepsi Kemudahan Penggunaan, dan Persepsi Risiko terhadap minat menggunakan pembayaran digital pada mahasiswa di Jabodetabek, Indonesia. Metode penelitian dalam riset ini adalah kuantitatif dengan teknik analisa data menggunakan deskriptif analitis. Hasil penelitian ini menunjukkan Influencer Sosial Media, Brand image perusahaan, Perceived risk berpengaruh negatif dan tidak signifikan. Sedangkan, Promotional benefit, Fintech knowledge, Perceived usefulness, berpengaruh positif dan signifikan. Diharapkan hasil penelitian ini akan memberikan kontribusi bagi perusahaan penerbit sebagai bahan kajian untuk mengembangkan bisnisnya, karena kelompok milenial ini memiliki potensi pasar yang besar karena cenderung mengikuti tren dan tanggap akan tekhnologi dibandingkan kelompok umur yang lain. Penelitian ini pula diharapkan mampu memberikan saran perbaikan untuk pemerintah terkait aturan dalam bisnis pembayaran digital di masa yang akan datang.
Kata Kunci : Minat Penggunaan, Preferensi Milenial, Pembayaran Digital.
ANALISIS KUALITAS PLATFORM E-MARKETPLACE TERHADAP LOYALITAS PELANGGAN (Studi Kasus: Pengguna Zilingo)
Authors: Ferdinand Erfina , Aransyah Muhammad Fikry , Bharata Wira
Published: December 2021

Penelitian ini bertujuan untuk menganalisis kualitas suatu platform e-marketplace Zilingo terhadap loyalitas pelanggannya, apakah sudah sesuai dengan kaidah penyajian platform e-marketplace yang baik dan benar serta melakukan evaluasi untuk mengukur dan meningkatkan serta memperbaiki kualitas layanannya yang masih kurang guna meningkatkan loyalitas pelanggan. Metode yang digunakan adalah metode Structural Equation Modelling melalui pendekatan Partial Least Square atau SEM-PLS. Data primer didapat dari penyebaran kuesioner secara online melalui Google Form dengan dukungan oleh data sekunder yaitu diantaranya buku, e-journal, dan website. Hasil dari penelitian ini menyatakan bahwa variabel e-service quality berpengaruh positif dan signifikan terhadap e-loyalty dengan dimensi yang paling berpengaruh yaitu dimensi reliabilitas. Dimensi ini berkaitan dengan fungsionalitas fitur-fitur yang ditawarkan oleh platform e-marketplace Zilingo. Fitur-fitur yang berfungsi sebagaimana mestinya menjadi indikator yang penting untuk meningkatkan e-loyalty pengguna Zilingo. Lalu didapati dalam penelitian ini bahwa variabel e-satisfaction berpengaruh negatif dan tidak signifikan terhadap e-loyalty. Dapat disimpulkan bahwa semakin baik suatu e-satisfaction maka tidak akan meningkatkan suatu e-loyalty. 
Kata Kunci: SEM-PLS, Platform E-Marketplace, E-Service Quality, E-Satisfaction, E-Trust, E-Loyalty.
Implantação do Building Information Modeling aos projetos de engenharia do sistema federal Brasileiro
Authors: Coan Débora Regina Thomaz do Nascimento , Souza Normelio Junior de , Queiroz Altamira de Souza
Published: December 2021

O presente artigo descreve a estratégia do Sistema Federal Brasileiro, para a propagação e implantação da tecnologia Building Information Modeling (BIM), para os projetos de engenharia das obras públicas diretas e indiretas até o ano de 2028. Neste contexto, o presente artigo, tem como questão norteadora: Como será realizada a implantação do Building Information Modeling para elaboração dos projetos de engenharia do Sistema Federal Brasileiro? O objetivo geral da pesquisa é fazer um levantamento sobre a implantação da tecnologia BIM para execução de projetos de engenharia do Sistema Público Federal Brasileiro e seus impactos. Através de pesquisas bibliográficas sobre o tema tratado, estuda-se o surgimento da tecnologia BIM, o processo de implantação no Brasil e as etapas da estratégia BIMBR para a solidificação da tecnologia. Mediante pesquisa bibliográfica, realiza-se a comparação de um projeto de moradia popular, através da modelagem tridimensional, usando-se a tecnologia BIM e o programa Cad, desse modo, comprova-se a economia de 11% no orçamento total da obra, a diminuição de 5 horas de trabalho no processo de modelagem e a redução de 4 horas no preenchimento da planilha de prestação de contas para o financiamento do projeto de moradia, disponibilizada pela Caixa Econômica Federal.
ВИКОРИСТАННЯ СУЧАСНИХ ТЕХНОЛОГІЙ ДЛЯ УПРАВЛІННЯ ПРОЄКТАМИ ТА ЇХ РЕСУРСАМИ У КРИЗОВИЙ ПЕРІОД
Authors: Гринкевич Світлана , Баховський Любомир
Published: December 2021

Робота присвячена розгляду процесів управління проєктами. Особлива увага приділяється антикризовим механізмам адаптації бізнес-процесів та методикам управління ризиками. Визначено теоретичні аспекти з метою виявлення причин ризиків, що виникають при управлінні проєктами, та класифіковано їхні стани, відповідно до етапу життєвого циклу проєкту. Предметом дослідження роботи є аналіз фундаментальних методик управління проєктами. Проаналізовано класифікаційні ознаки явища управління проєктами. Також у статті визначені сутність та зміст фаз управління проєктом та їх трактування. Аналіз базувався на сучасному світовому досвіді теми дослідження, без конкретизації.
Development of a fisheye-based information search processing aid (FISPA) for managing information overload in the web environment
Authors: Turetken Ozgur , Sharda Ramesh
Published: December 2021

Information technologies have proliferated at an unprecedented rate to provide access to information across geographical boundaries. However, this proliferation has led to an information overload. Information overload has adverse impacts on information use and decision quality. This research focuses on the overload problem resulting from a web search, and proposes a potential remedy. We develop the requirements of a system that makes use of clustering and visualization for browsing the results of a typical web search. Based on this model, we develop a prototype that visualizes search results by first organizing them into a hierarchy according to their individual contents. This system presents a visual overview of the groups in this hierarchy, and lets the users focus (zoom) on specific groups of interest. One general problem with zooming within hierarchical structures is the separation between the details and the context. To address this problem, we implement a fisheye zooming capability in our system. This paper describes a typology of the various components necessary for addressing the problem and then the proposed solution based upon a fisheye view-based visualization. Next, the specific visualization algorithm and the system implementation are described. We conclude with research questions for further development of such interfaces for presentation of the results from web searches.
Impoliteness Manoeuvres and Its Motives in Indonesia Lawyers Club Talk Show
Authors: Putri Dita Sukmawati , Djatmika  , Nugroho Miftah
Published: December 2021

The use of impolite language is often found in various areas of conversation, both formal and informal conversations. Being polite is different from speaking rudely. Impoliteness is often expressed with harsh words. Impoliteness can be expressed even with a sentence of praise. The Indonesia Lawyers Club talk show is a television program that presents formal discussions on political and government issues in Indonesia. This study focuses on the reasons for using impoliteness that occurs in the dialogue on the Indonesia Lawyers Club talk show. This research is a qualitative descriptive study using a pragmatic approach. The data in this study are in the form of dialogues that contain impoliteness. The source of this research data is taken from the talk show Indonesia Lawyers Club. The data analyzed in this study are in the form of natural oral data. The data analysis method used is the referential equivalent method. The presentation of data analysis used is informal presentation techniques. The results of this study indicate the discovery of 4 impoliteness strategies and 3 reasons for using impoliteness. The 4 strategies are bald on record, positive impoliteness, negative impoliteness, and mock politeness. The reasons for using impoliteness in the Indonesia Lawyers Club talk show include the feeling that their opinion is the most correct, wanting to embarrass the speech partner and the speaker's personal interests.
Under The Sun’s Flag, on The Edge of Tangerang City: History of the Establishment of the College and Branch Leaders Muhammadiyah Pasar Kemis, Tangerang Regency
Authors: Rizal Aslama Nanda
Published: December 2021

Muhammadiyah has been known as an organization engaged in education and social affairs. In its work, since it was founded by KH Ahmad Dahlan in 1912, Muhammadiyah has been active in both fields while spreading its wings throughout the archipelago. One of these 'wings' was developed in Pasar Kemis, a sub-district located in Tangerang Regency, Banten Province. In this sub-district, Muhammadiyah is actively expanding its work in the field of education and social activities. This paper aims to examine the role of Muhammadiyah in the Pasar Kemis District and the dynamics of its history and movement in this sub-district. Moreover, it seeks to describe the influence of the emergence of the Muhammadiyah organization in Pasar Kemis Sub-district, Tangerang Regency, Banten Province. Archives, documents, notes, photos, and various decrees from internal organizations, individuals to the Tangerang Regency Government were dissected and reviewed. The result obtained is Muhammadiyah organization has advantages that seem very difficult to imitate by other organizations, including NU. More precisely, it is about tangible evidence to the public. This is manifested in various Muhammadiyah charities such as schools, hospitals, zakat institutions (LAZIS-MU), universities to universities, and others. The business charity was established and run not for business for its members but for the community. The typical Muhammadiyah business charity is different from corporations or private foundations, which are usually owned by individuals or a handful of groups (oligarchy).
New wave behaviors of the (3+1)-dimensional Date-Jimbo-Kashiwara-Miwa equation
Authors: ŞENER Sıdıka Şule
Published: December 2021

In this study, the (3+1)-dimensional Date-Jimbo-Kashiwara-Miwa equation that indicated the propagation of nonlinear dispersive waves in inhomogeneous media is given for consideration. The generalized exponential rational function method is used to seek some new exact solutions for the considered equation. The three-dimensional surfaces and two-dimensional graphs of the obtained solutions are plotted by choosing the appropriate values of the involving free parameters.