bluuebunny/crossref_metadata_2025 huggingface dataset:
Diyarbakır’ın Destinasyon Rekabetçiliğinin Turizm Paydaşları Tarafından Değerlendirilmesi
Authors: Özaltaş Serçek Gülseren , Ataman Doğan , Ateş Cüneyt
Published: January 2025

Destinasyonların daha büyük pazar payları elde etmesinde destinasyon rekabet gücü önemli bir unsurdur. Turizm yöneticileri ve uygulayıcıları, destinasyonun rekabet avantajlarını tespit etmeli ve bu tespitlerden yola çıkarak destinasyonun rekabetçi konumunu analiz etmelidir. Ülkelerin veya destinasyonların turizm sektöründen ne ölçüde yararlanabileceği ulusal ve uluslararası pazardaki rekabetçi konumuna bağlıdır. Bu bilgiler ışığında bu araştırmanın amacı, Diyarbakır’ın destinasyon rekabet gücünün turizm paydaşları tarafından değerlendirilmesi ve katılımcıların destinasyon rekabet gücü algılamaları arasında farklılık olup olmadığının belirlenmesidir. Bu araştırmanın önemi, destinasyon politika yapıcılarına rehberlik etmektir. Araştırmanın amacı doğrultusunda, Diyarbakır destinasyonunda yer alan turizm paydaşlarına yüz yüze anket yöntemiyle uygulanan 403 adet anket formu vasıtasıyla elde dilen verilere tanımlayıcı istatistikler ve farklılık analizleri uygulanmıştır. Yapılan analizler sonucunda, Diyarbakır’ın destinasyon rekabetçiliği konusunda genel olarak güçlü unsurlara sahip olduğu ve bu unsurlar içerisinde birinci derecede önemli unsurların doğal kaynaklara, ikinci derece önemli unsurların destek kaynaklara dayandığı saptanmıştır. Araştırmanın bir diğer sonucuna göre, destinasyon rekabetçiliği yapılarından doğal kaynaklar ile yapay kaynaklar, destek kaynaklar, destinasyon yönetimi, durumsal koşullar ve talep koşulları arasında istatistiksel olarak anlamlı bir farklılık ortaya çıkmıştır.
Determining Digital Maturity in Metropolitan Municipalities: The Example of Sakarya and Kocaeli Metropolitan Municipalities
Authors: Nam Selçuk
Published: January 2025

Digital transformation in municipalities is vital for improving service delivery, increasing operational efficiency and encouraging citizen participation. This study aims to determine the factors that determine the digital maturity levels of institutions and the effects of these factors by focusing on the digital transformation process of Sakarya and Kocaeli Metropolitan Municipalities. In this research, case study design was used to investigate digital maturity in an in-depth and holistic way in the institutional context and to analyze the case of metropolitan municipalities in a real-world context. Data on municipalities' digital initiatives, policies and online platforms were obtained from semi-structured interviews, documents and observation notes. Data were analyzed and interpreted using single-case and cross-case analysis techniques using MAXQDA qualitative analysis software. While both municipalities have made significant progress in their digital transformation efforts, there are significant gaps and areas for improvement. Research findings point to vital factors influencing digital maturity, including leadership commitment, organizational culture, technical infrastructure, data management and citizen engagement. Holistic and comprehensive models that evaluate various dimensions such as technological infrastructure, digital services, data management, and cyber security provide a suitable framework for understanding digital maturity components in municipalities. Each element, from appropriate technological infrastructure and data governance practices to user-friendly e-government services and competent workforce, is critical to raising digital maturity. Municipalities can overcome the complexities of digital transformation through comprehensive digital strategies, user-centered design, and collaboration with stakeholders.
Giovanni Brindesi’nin Mesire Konulu Eserlerinde Doğulu Kadın İmgesi
Authors: Arda Onar Neşe
Published: January 2025

19. yüzyılda seyahat koşullarının iyileşmesiyle Doğu’ya seyahat eden ressam, seyyah ve yazarların eserleri, Osmanlı toplumunda kadının sosyal yaşamına ışık tutması açısından önemlidir. Bu dönemde etkili olan Oryantalist resim akımındaki eserlere baktığımızda Doğulu kadın konulu resimlerde Batı’nın arz talep meselesine göre şekillenen Doğulu kadın imgesi yaygındır. Oryantalist ressamlar içerisinde Doğu seyahati yaparak gerçek Doğulu kadın imgesini yansıtan İtalyan ressamlardan hem İstanbul’da uzun yıllar yaşamış ve toplumun sosyal ve kültürel kodlarına hâkim hem de dönem kaynakları ile resimleri arasında büyük paralellik bulunan Giovanni Brindesi’nin Doğulu kadın imgesi konulu eserleri çalışmamız açısından önemlidir. İstanbul’da yaşamış bir ressam olan Giovanni Brindesi’nin Doğulu kadını günlük yaşamın bir parçası olarak gördüğü sekiz adet mesire sahnesi içeren tablosu vardır. Mesire sahnelerinde İtalyan Oryantalist ressamların diğer Oryantalist ressamlardan farkı ortaya koyularak hem o dönemin sosyal yaşantısına pencere açılmış hem de kadının dışarıdaki alanıyla ilgili tespitlerde bulunulmuştur. Yabancı ressamlar ve yazarların gözlem yapma imkânı bulabildiği ve gördüklerini eserlerine aktarabildikleri mesire yerleri, Doğulu kadınların en çok tercih ettiği eğlence alanları olarak karşımıza çıkmaktadır. Özellikle Kâğıthane ve Göksu gibi mesire yerleri bu dönemde kamusal alanda kadının görülebildiği yerler olması açısından çok önemlidir. Brindesi dışında mesire konusunu resmeden başka ressamlar olmakla birlikte İstanbul’da yaşayan ve yabancı gözüyle ele alınmış mesire sahnelerindeki kadın imgesinin gerçekçi yansımaları irdelenecektir.
FINANCIAL SUSTAINABILITY OF TERRITORIAL COMMUNITIES: A THEORETICAL DISCOURSE
Authors: SOROKOVYI Danylo
Published: January 2025

Introduction. The war in Ukraine has necessitated a change in scientific approaches to defining the role, functions and directions of territorial communities - to consider them primarily not from the perspective of development and economic growth, but rather from the perspective of maintaining resilience under the influence of external shocks. The need to change the approach "coincided" with the expansion of the range of crisis phenomena in the economy, which led to increased scientific interest in the concept of resilience in the personal, organizational and territorial dimensions.

The purpose of the article is to study scientific approaches to disclosing the essence and substantiating the determinants of financial sustainability of territorial communities.

Results. The multidisciplinary nature of the concept of "sustainability" is substantiated. The evolution of scientific thought on the sustainability of socio-ecological systems in the economic literature is analyzed: the concept of sustainability was used to describe the system's response to a shock and the course of its recovery. At the present stage, approaches to determining the sustainability of socio-ecological and economic systems are based not only on maintaining the balance, but also on the dynamics of the system in conditions when the balance is disturbed. The interrelationships between the concepts of "sustainability", "adaptability" and "transformability" are established. The financial sustainability of a territorial community is considered as a component of sustainability, which includes not only financial resources and mechanisms for managing them, but also the community economy as a basis for consolidating resources, human and social capital for managing them.

Conclusions. The financial sustainability of a territorial community is the ability to manage financial resources stably and ensure the full provision of public services to residents in the face of financial and economic shocks, to adapt to changes, to transform under the influence of external factors through innovation, changes in behavior and approaches to management and use of the accumulated resource potential as a result of gaining new financial knowledge and experience. The determinants of the financial sustainability of territorial communities are identified: accumulated resource potential, financial inclusion, financial literacy and behavior, social capital and external relations.
Выбор мембран и мембранных элементов для промышленной подготовки воды ультрафильтрацией
Authors: Ларионов С.Ю. , Пантелеев А.А. , Рябчиков Б.Е. , Самбурский Г.А.
Published: January 2025

Технология очистки воды ультрафильтрацией практически начала применяться в России с начала 2000-х годов, когда на Юго-Западной водопроводной станции Москвы была введена в эксплуатацию крупнейшая в Европе установка подготовки питьевой воды производительностью 250 тыс. м³/сут (10 500 м³/ч) и на Новочеркасской ГРЭС – установка водоподготовки производительностью 250 м3/ч. В настоящее время работают десятки таких установок. При этом используются мембраны самых разных конструкций, изготовленных из разных материалов и в различном аппаратурном оформлении. Как правило, при грамотном подборе оборудования и условий его эксплуатации срок службы ультрафильтрационных мембран составляет от 4 до 10 лет. При этом требуется проведение обязательных предварительных пилотных испытаний, однако многие их игнорируют, считая, что процесс давно отработан и достаточно прост. В реальности выбор оптимальных мембранных элементов и режимов работы является непростой задачей, а ошибки влекут за собой большие финансовые и репутационные потери.

The technology of water purification by ultrafiltration has come into operation in Russia since the early 2000s with the commissioning of the largest drinking water treatment plant in Europe with a capacity of 250 thousand m³/day (10,500 m³/h) at the South-West Water Treatment Plant in Moscow, and a water treatment plant with a capacity of 250 m3/h at the Novocherkassk Regional Power Plant. Dozens of such plants are currently in operation. Membranes of various designs, made of different materials and with various instrumentation are used. As a rule, provided proper selection of equipment and its operating conditions, the service life of ultrafiltration membranes is from 4 to 10 years. Herewith, mandatory preliminary pilot tests are required; however, many a man ignore them, taking the view that the process has been tried-and-true and simple enough. Actually, the selection of the optimal membrane elements and operating modes is a difficult task, and errors entail large financial and reputational losses.
Методика моделирования и расчета водопроводных сетей с источниками переменного напора и подачи
Authors: Гудков А.Г.
Published: January 2025

Статья посвящена совершенствованию методики гидравлического расчета наружных водопроводных сетей с источниками, в которых давление и расход воды связаны определенной зависимостью. Предложены изменения в классическую схему расчета с единым фиктивным источником, которые обеспечивают учет нескольких разнотипных источников, подключенных к одному узлу сети. Для этого предлагается введение фиктивного промежуточного узла и участков между каждым источником и сетью, образующих новые контуры. Предложен общий алгоритм гидравлического расчета и приведена методика определения участковых потерь напора на фиктивных участках. Для иллюстрации методики дан пример последовательности расчета двухконтурной сети с двумя насосными станциями и двумя потребителями. Обнаружено, что сходимость метода Ньютона для решения системы нелинейных алгебраических уравнений, моделирующих потокораспределение по двум законам Кирхгофа, может быть улучшена при модификации уравнений контурных давлений. Представлено компьютерное онлайн-приложение для проверки работоспособности и реализации предложенной методики.

The paper dwells upon improving the hydraulic calculation method for water supply networks with sources with the pressure and water flow related by a certain dependence. Changes in the traditional calculation scheme with a common fictitious source are proposed that provide for considering several different types of sources connected to one network node. For this purpose, introducing a fictitious intermediate node and sections between each source and the network that form new contours is proposed. A general algorithm for hydraulic calculation is proposed and a method for determining sectional pressure losses in fictitious sections is given. An example of the calculation sequence for a double circuit network with two pumping stations and two consumers is given to illustrate the method. It is found that the convergence of the Newton method for solving a system of nonlinear algebraic equations simulating flow distribution according to two Kirchhoff's laws can be improved by modifying the equations of contour pressures. An online computer application for testing the operability and implementation of the proposed method is presented.
SKOR AKTIVITAS PREBIOTIK TEPUNG SINGKONG TERHADAP LACTOBACILLUS BULGARICUS, STREPTOCOCCUS THERMOPHILUS, LACTOBACILLUS ACIDOPHILLUS DIBANDING ESCHERICHIA COLI
Authors: Rahmawati Dwita Mukti , Puspaningtyas Desty Ervira , Sari Puspita Mardika , Styaningrum Silvia Dewi , Sucipto Adi
Published: January 2025

Latar belakang: Singkong atau ubi kayu (Manihot esculenta crantz) merupakan salah satu makanan sumber karbohidrat. Tingginya kandungan karbohidrat tidak tercerna seperti serat pangan dan pati resisten pada singkong berpotensi sebagai sumber prebiotik. Potensi tepung singkong sebagai sumber prebiotik sudah pernah dilakukan sebelumnya perlu dilakukan kajian lebih luas terhadap bakteri lainnya untuk semakin membuktikan peranan singkong sebagai sumber prebiotik. Tujuan: Penelitian ini bertujuan untuk menganalisis secara in vitro skor aktivitas prebiotik tepung singkong terhadap bakteri saluran cerna Lactobacillus bulgaricus, Streptococcus thermophilus dan Lactobacillus acidophillus dibandingkan Escherichia coli. Metode: Penelitian ini merupakan jenis penelitian observational laboratory study yang menganalisis potensi prebiotik pada tepung singkong  melalui analisis skor aktivitas prebiotik. Substrat yang digunakan adalah tepung singkong, inulin dan glukosa. Isolat bakteri yang digunakan adalah Lactobacillus bulgaricus, Streptococcus thermophilus, Lactobacillus acidophillus dan Escherichia coli. Media untuk inokulasi bakteri adalah MRS Broth dan M9. Media penumbuhan  mikrobiologi yang digunakan adalah MRS Agar dan Nutrient Agar  Hasil: Hasil penelitian menunjukkan bahwa skor aktivitas prebiotik dari yang  tertinggi hingga terendah pada tepung singkong terdapat pada bakteri Lactobacillus bulgaricus (0,16), Lactobacillus acidophillus (-0,17) dan Streptococcus thermophilus (-0,26). Pada inulin semua hasil akhir menunjukkan angka positif dimulai dari yang tertinggi hingga terendah yaitu pada bakteri Lactobacillus bulgaricus (0,64), Lactobacillus acidophillus (0,33) dan Streptococcus thermophilus (0,28). Kesimpulan: Tepung singkong memiliki potensi prebiotik terhadap bakteri Lactobacillus bulgaricus, namun tidak memiliki potensi prebiotik terhadap bakteri Streptococcus thermophilus dan Lactobacillus acidophillus.
PENGETAHUAN IBU HAMIL RISIKO TINGGI DENGAN PERSIAPAN PERSALINAN
Authors: Saragih Sidahuruk Helga Kristiani , Sunarsih Tri
Published: January 2025

Latar belakang: Banyak ibu hamil hanya mengetahui sedikit tentang proses yang terjadi dalam dirinya, perubahan apa saja yang terjadi, dan bagaimana proses kehamilan dan persalinan secara normal. Kurangnya pengetahuan dan ketidaksiapan tentang apa yang diharapkan selama persalinan dapat menyebabkan kecemasan dan ketakutan, periode kehamilan yang tidak nyaman, dan bahkan kelahiran yang sulit. Persiapan dalam menghadapi persalinan sangat bergantung pada pengetahuan ibu bersalin pada saat ibu melakukan ANC. Tujuan: Penelitian ini bertujuan untuk hubungan tingkat pengetahuan ibu hamil risiko tinggi dengan persiapan persalinan di Klinik Pratama Amanda. Metode: Desain penelitian yang digunakan adalah cross sectional study. Populasi yang digunakan adalah seluruh ibu hamil risiko tinggi trimester III. Teknik dalam pengambilan sampel adalah total sampling. Jumlah sampel dalam penelitian ini adalah 35 ibu hamil risiko tinggi trimester III yang dideteksi menggunakan Kartu Skor Poedji Rochyati (KSPR). Penelitian ini dilaksanakan di Klinik Pratama Amanda. Penelitian ini dianalisis menggunakan analisis korelasi spearman rank. Hasil: Karakteristik usia 20-35 tahun sebanyak 31 responden (88,6%), pendidikan SMA/MA sebanyak 21 responden (60%), tidak bekerja sebanyak 15 responden (42,9%), primigravida sebanyak 19 responden (54,3%), skrining kspr: penyakit pada ibu hamil yaitu kurang darah sebanyak 7 responden (18%), tingkat pengetahuan ibu baik sebanyak 31 responden (89%), persiapan persalinan siap sebanyak 34 responden (97%) dan critical point (P4K) siap 21 responden (60%). Nilai p-value sebesar 0,001 artinya ada hubungan yang signifikan (berarti) antara variabel tingkat pengetahuan ibu hamil risiko tinggi dengan persiapan persalinan. Kesimpulan: Ada hubungan yang signifikan tingkat pengetahuan ibu hamil risiko tinggi dengan persiapan persalinan.
PENGARUH PERMAINAN TRADISIONAL LOMPAT TALI TERHADAP PENURUNAN BERAT BADAN PADA REMAJA PUTRI OVERWEIGHT DAN OBESITAS
Authors: Roslianti Hari Perdana , Astuti Ari Tri , Mahmudah Umi
Published: January 2025

Latar belakang: Masalah gizi yang sering terjadi di kalangan remaja yaitu overweight dan obesitas. Masalah ini terjadi karena adanya ketidakseimbangan antara energi yang masuk dengan energi yang dikeluarkan dan kurangnya aktivitas fisik sehingga menimbulkan penambahan berat badan. Lompat tali merupakan aktivitas fisik yang dapat menurunkan berat badan dengan cara membakar lemak dalam intensitas latihan rendah dan jangka waktu lama. Tujuan: untuk mengetahui pengaruh permainan tradisional lompat tali terhadap penurunan berat badan pada remaja putri overweight dan obesitas. Metode: Penelitian ini merupakan penelitian quasi experiment dengan rancangan one group pretest posttest. Penelitian dilaksanakan pada Oktober 2018 – Mei 2019 di Asrama SMP Stella Duce 2 Yogyakarta. Responden penelitian berjumlah 12 remaja putri yang memenuhi kriteria. Pemilihan responden dilakukan secara purposive sampling. Pemberian intervensi permainan tradisional lompat tali dilakukan selama 8 minggu. Pengukuran berat badan diambil sebelum dan setelah intervensi menggunakan timbangan digital. Data dianalisis menggunakan Paired T-test. Hasil: Rerata berat badan pre dan post intervensi adalah 60,12 ± 9,98 kg dan 60,26 ± 10,02 kg secara berurutan. Perubahan berat badan selama intervensi sebesar 0,14 ± 1,17 kg. Tidak ada pengaruh permainan tradisional lompat tali terhadap penurunan berat badan (p= 0,685). Kesimpulan: Tidak ada pengaruh permainan tradisional lompat tali terhadap penurunan berat badan pada remaja putri overweight dan obesitas.
Hot-wire-type micromachined chemiresistive gas sensors for battery-powered city gas alarms
Authors: Dougami Naganori , Miyata Takeshi , Orita Taishi , Nakatani Tadashi , Kakunaka Rui , Taniguchi Takafumi , Mitsuhashi Hirokazu , Nakao Shoichiro
Published: January 2025

Metal oxide semiconductor (MOX) chemiresistive gas sensors used in gas alarms have contributed to the safe use of city gas and liquid petroleum gas. In this study, we successfully fabricated hot-wire-type MOX sensors using micro-electro-mechanical systems (MEMS) technology. The hot-wire type structure, in which an electrode plays dual roles in detecting and heating, was adopted for efficient production. Owing to the miniaturization together with the thermal insulation, the sensors exhibited a fast thermal response. The average power consumption of the sensor in the pulsed operation was less than 100 μW. The sensor exhibited high sensitivity of more than 100 mV to 3000 ppm methane and showed low cross-sensitivity to interference gases such as ethanol and hydrogen. These sensing properties were retained for more than five years, demonstrating excellent long-term stability of the sensors.
Forensic characteristics of road traffic crimes involving car-sharing vehicles
Authors: Karnaukhova O. G. , Leinova O. S.
Published: January 2025

The article highlights current issues in modern Russian society related to forensic characteristics of road traffic crimes involving car-sharing vehicles. The authors emphasize the importance of resolving these alerting issues. The article reviews the driver actions and their assessments in certain cases. It also provides the statistics involving these vehicles, and offers recommendations for improving the investigation process
Challenges in the legal regulation of competition in the context of the digital transformation of the economy
Authors: Volnov A. S. , Dalinin A. V.
Published: January 2025

Competition law and policy foster, maintain and encourage competition in markets by establishing and ensuring prohibitions on business practices that may harm competition. The risk of anticompetitive practices is shown to increase with the tendency of large digital companies to form diversified conglomerates by developing new products and services or acquiring promising start-ups that reduce competition in the market. These companies operate through unique business models, and their use of advanced technologies and data exacerbates existing anticompetitive practices while creating new ones. Big data is explored as a key tool for gaining competitive advantages, and the complexities of interpreting artificial intelligence algorithms are discussed, particularly in relation to tacit collusion. The study also investigates the antitrust regulation of digital platforms in the European Union (EU) and China, highlighting the emergence of dominant “structuring” platforms in the markets. The authors argue that ensuring competitive market functioning in the presence of these platforms has become increasingly difficult for regulators. A number of regulatory changes are proposed to address these challenges
Liability for violation of competition rules in entrepreneurial activity: Criminal and administrative aspects
Authors: Antonov A. Yu. , Alekseev V. V. , Syrova M. A.
Published: January 2025

According to the author’s standpoint, antitrust rules are aimed at promoting fair competition, preventing monopolies, and protecting consumers. They ensure a level playing field in entrepreneurial environment. Among other things, compliance with legislation regulating competitive relations is enforced through state coercion measures. The article argues that one of the pressing issues of modern jurisprudence is the study of the administrative and criminal aspects of liability for violation of competition rules, considering relevant circumstances. It analyzes the systemic relationship between antitrust violation proceedings, administrative infractions, and criminal offenses. The study emphases the legislator’s imperative regulation of the sequence of coercive measures applied in cases of competition rule violations. The author proposes a perspective on determining the moment an anticompetitive offense is detected, particularly for calculating reverse fines. The possibility of combining administrative and jurisdictional proceedings with criminal proceedings into a single judicial process is also explored. Given that the economy digitalization creates a new model of competition, it is proposed to introduce as an aggravating circumstance the commission of an anticompetitive action on a digital platform or using algorithms or artificial intelligence
Cytokine Expression in Cancer Survivors Suffering From Chronic Pain: A Systematic Review
Authors: Meeus Mira
Published: January 2025

BACKGROUND: Chronic cancer-related pain remains underdiagnosed and undertreated, although it affects 40% of cancer survivors. Recent insights suggest that cytokine signaling between immune, neuro, and glial cells contributes to chronic pain.

OBJECTIVES: This study systematically reviewed cytokine levels and their relation to chronic cancer-related pain and, additionally, investigated differences in cytokine levels between cancer survivors with and without chronic pain.

STUDY DESIGN: Systematic review.

METHODS: This systematic review was conducted and reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines (PRISMA). The study conducted a systematic literature search in the databases PubMed, Web of Science, and Embase for articles examining cytokine levels and pain experience at a time point of a minimum of 3 months post-cancer diagnosis. Pain experience was categorized into a total pain score, pain intensity, and pain interference. The risk of bias was assessed using the Newcastle Ottawa Scale.

RESULTS: Eight articles were included, investigating 6 cancer types and 30 cytokines. Moderate evidence was found for pro-inflammatory cytokine IL-6 to be correlated with pain intensity, of which higher levels are observed in cancer survivors experiencing chronic pain compared to pain-free survivors. Moderate evidence was found for TNF-alpha to be not correlated with any pain experience, which is similar for anti-inflammatory cytokines IL-8 and IL-10 with pain intensity. For the remaining 26 cytokines and pain outcomes, only limited evidence was found for an association or alteration.

LIMITATIONS: The number of included studies was small. Overall, studies showed a moderate risk of bias, except one indicated a high risk of bias.

CONCLUSION: More standardized post-cancer treatment studies are warranted to confirm these results and explore associations and alterations of other cytokines. Nonetheless, moderate evidence suggests that elevated levels of IL-6, in contrast with TNF-alpha levels, are correlated with pain intensity in cancer survivors experiencing chronic pain compared to pain-free survivors.

KEY WORDS: Cytokines, interleukin, chronic cancer-related pain, chronic pain, persistent pain, cancer pain, IL-6, TNF-alpha
Una mirada compleja en el desarrollo tecnológico del pueblo judío
Authors:   Universidad de San Carlos de Guatemala, Hernández Ortíz Julio César
Published: January 2025

¿Qué características tipifican a esta población que los hace fenológicamente diferentes a los otras? ¿por qué el judío ha sido discriminado? ¿qué hay de misticismo o esoterismo en ellos?, siendo uno de los pueblos más antiguos que existen en el planeta. Su historia se remonta al momento cuando Abraham fue llamado de Ur de los caldeos (parte del territorio de Irak) a una tierra que su Dios le prometió, a la cual le llamaban Canaán, allí tuvieron un hijo en plena vejez con su esposa Sara (90 años ella y 100 él), al que llamaron Isaac. A este hijo sus padres no permitieron que tuviera esposa cananea, sino que fuera a buscarla con su parentela que quedó siempre en la parte de lo que hoy es Irak, con el fin de que no hubiera entropía en su familia y que siguiera el eugenismo.
Effects of Prostaglandin Analogue on the Central Retinal Thickness in Patients with Type 2 Diabetes Mellitus
Authors: Salih Suzan Kahatan M. , Abdulla Marwan Younis , Ali Mohammed Abdulsahib
Published: January 2025

Purpose:  To determine the central macular thickness in patients with type 2 Diabetes using Latanoprost eye drops and to compare with type 2 diabetic patients using Timolol eye drops.
Study Design:  Quasi experimental study.
Place and Duration of Study:  Al-Noaman Teaching Hospital from February 2023 to April 2023.
Methods:  One hundred diabetic patients were divided into two equal groups (Timolol group and Latanoprost group). Visual acuity was tested using Snellen chart, IOP was measured with Goldmann Applanation Tonometer, central corneal thickness (CCT) measurement was done to correct IOP for CCT.  Optical coherence tomography (OCT) was used to measure central retinal thickness (CRT).
Results:  The mean age of Timolol group was 57.91±1.6 years, which was very close to the mean age of Latanoprost group (57.57±1.63 years). There were 30 females and 20 males in each group. HbA1Cwas 8.99±0.47% in Timolol and 6.28±0.08% in Latanoprost group (p <0.001). The IOP showed statistically lower levels in Timolol group in comparison to Latanoprost group, 28.81±0.93 mmHg in comparison to 29.56±1.04 mmHg, respectively. In Timolol group, visual acuity significantly improved, the IOP was reduced, and the CRT was significantly lowered. However, in Latanoprost group, the pre and post treatment values showed that only the IOP significantly improved. Visual acuity and CRT were statistically and clinically the same.
Conclusion:  Latanoprost may increase the central retinal thickness in diabetic patients without diabetic macular edema, however the rationale for stopping the medication in low-risk patients is still lacking.
A Pilot Study on Knowledge, Attitude, and Practice Regarding the Use of Dietary Supplements as Adjuvant Therapy for Glaucoma
Authors: Prema Chande  , Renu Thakur  , Priyanka Udaybhan Gupta
Published: January 2025

Purpose:  To find out knowledge, attitude, and practice among ophthalmologists regarding nutritional supplements in the management of glaucoma.
Study Design:  Cross sectional study.
Place and Duration of Study:  Lotus Eye Hospital and the College of Optometry.
Methods:  A questionnaire-based cross-sectional pilot study was conducted. All questions in the 4-section questionnaire were mandatory. A Google form was created to share the questionnaire with potential participants. The final questionnaire link was emailed, distributed, and posted on social media to ophthalmologists. Final analysis was done after the data was manually entered into an excel sheet. Chi-square test was used to find out any association of knowledge, attitude, and practice based on years of experience, gender, and place of practice. P value < 0.05 was considered statistically significant.
Results:  Out of 156 ophthalmologists, there were 99 males and 57 females. The average age was 41.88±6.15 years. Only 57.5% had good to fair knowledge, 25% had a positive attitude towards the role of nutritional supplements in glaucoma management, and practice patterns showed that only 30% prescribed supplements. The commonly prescribed supplements were Lutein, Zeaxanthin, flavonoids, and Omega3. A statistically significant 73% of respondents worked in private hospitals and 27% in public hospitals (p=0.005). With standard glaucoma therapies, 58% of respondents with 6-10 years of experience did not prescribe nutritional supplements. Limitations of the study include included a relatively small sample of 156 ophthalmologists, limiting the generalizability of the findings to a broader population. The distribution of the questionnaire via email and social media may have introduced selection bias, as only those with internet access and willingness to participate were included.Reliance on self-reported responses may lead to response bias, as participants might overstate or understate their knowledge, attitudes, and practices. The study did not assess whether the use of nutritional supplements by the ophthalmologists led to improved patient outcomes, which limits the practical implications of the findings. Addressing these limitations in future studies, such as through larger sample sizes, randomized designs, and longitudinal approaches, could provide more robust and generalizable insights into the role of nutritional supplements in glaucoma management.
Conclusion:  The study results indicate that only 1 in 3 ophthalmologists administer supplements as adjuvant therapy for glaucoma. Randomized controlled trials of nutritional supplements as glaucoma adjuvant therapy can improve ophthalmologists' knowledge, attitude, and practice.
Visual Acuity and Refractive Errors in Toddlers
Authors: Rimayanti Ulfah , Hasan Nurfitriyani A.W. , Jamaluddin Sri Rezki Wahdania , Fitrah Muhammad , Syauqad Muhammad
Published: January 2025

Purpose:  Uncorrected refractive error is the leading cause of visual impairment in children worldwide, especially in this digital era. The purpose of this study was toexamine toddlers' visual acuity (VA) and refractive errors in several playgroups and kindergartens in Makassar and Gowa, Indonesia.
Study Design:  Descriptive cross-sectional study.
Place and Duration of Study: Four Playgroups and Kindergartens in Makassar and Gowa, Indonesia from July 2023 to August 2023.
Methods:  The subjects of this study were 245 playgroup and kindergarten students. An ophthalmologist and an experienced optometrist examined visual acuity and refractive errors of the subjects using Kay Picture test linear crowded book and a Retinoscope, respectively. The data were analyzed using the One-Way ANOVA test and the Chi-square test.
Results:  Thirty-four children out of 245 (13.87%) had decreased visual acuity. One subject had myopia (2.9%), 21 had simple myopic astigmatism (61.8%), seven had compound myopic astigmatism (20.6%), three had compound hyperopic astigmatism (8.8%), and two subjects had mixed astigmatism (5.9%).Males had higher prevalence of decreased visual acuity as compared to females. There was no significant difference in visual acuity of different age and gender (p=0.437; p=0.312).
Conclusion:  The prevalence of reduced visual acuity in children aged two to six years was 13.87%. The most frequently encountered refractive error was simple myopic astigmatism, accounting for 61.8% of cases.
Newly Developed Head-Mounted Ultraviolet-Activated Riboflavin Device for Corneal Cross-Linking Therapy
Authors: Edy Wibowo  , Datu Respatika  , Indra Tri Mahayana  , Suhardjo Pawironanu  , Muhammad Bayu Sasongko
Published: January 2025

Purpose:  To compare the effectiveness of a newly developed head-mounted device (UV-GAMA) with traditional UV-CXL in terms of bacterial and fungal eradication.
Study Design:  Pre-clinical experimental study.
Place of Study:  Department of Microbiology, Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada.
Methods:  Bacterial and fungal isolates were cultured and suspensions were created to make a solution of 108/ml. Each test series had a non-illuminated control vessel without bacterial or fungal inoculation as a negative control. Every bacterial and fungal isolate was treated with 30 minutes of UV radiation. The bacterial and fungal suspension was cultured for 24 hours and 96 hours, respectively. The number of CFU was counted for each solution, as well as the corresponding control solution, and the concentration of bacteria was calculated.Two-way ANOVA and the student t-test were used for statistical analysis. The results of each bacterial/fungal count were examined separately. The level of significance was fixed at 5%.
Results:  Treatment with riboflavin + UV-GAMA and riboflavin + UV-CXL showed significantly reduced bacterial and fungal colonies compared to the positive control. Thus, riboflavin + UV-GAMA and riboflavin + CXL showed a similar outcome in terms of reducing bacterial colonies.
Conclusion:  The newly developed UV-GAMA head-mounted device shows a comparable result to the established CXL device. This finding emphasizes that the newly developed UV-GAMA can be used as an alternative to the existing CXL device.
Trends in Diabetic Retinopathy Severity among Patients at A Tertiary Care Eye Hospital: A Call to Strengthen Preventive Care
Authors: Napitupulu Nadya Beatrix Yohanna , Virgana Rova , Sirait Susanti Natalya , Widihastha Sri Hudaya
Published: January 2025

Purpose:  To analyze trends in diabetic retinopathy (DR) and its management at a tertiary healthcare center from January 2016 to December 2019.
Study Design:  Descriptive study.
Place and Duration of Study:  National Eye Center, Cicendo Eye Hospital, from August to September 2020.
Methods:  Data were obtained from the diabetic retinopathy database in the vitreo-retina unit. Information on patients’ sex, age, diagnosis, and treatment from each year was retrospectively reviewed. Inclusion criteria encompassed all first-time DR patients scheduled for pan-retinal photocoagulation (PRP) laser, anti-VEGF injection, or pars plana vitrectomy (PPV). Patients with incomplete data or repeated visits were excluded. Among 63,824 records analyzed, 22,169 met the inclusion criteria. Patients were categorized into vision-threatening diabetic retinopathy (VTDR), requiring treatment at the first visit, and non-VTDR.
Results:  Of the 22,169 patients included, 53.88% were female, and the majority were aged between 50 and 59 years. VTDR accounted for 19.12% of cases, while 80.88% were non-VTDR. Annual trends revealed changes in DR management approaches, with an increasing prevalence of VTDR and PPV emerging as the most frequently performed treatment.
Conclusion:  The predominance of non-VTDR cases highlights the urgent need for improved DR management at primary and secondary healthcare levels. Strengthening early detection and intervention protocols is essential to prevent disease progression and alleviate the burden on tertiary care facilities.
A New Frontier of Hope: Highlighting the Promising Potential of Spliceosome Inhibitor E7107 in Treating SF3B1 Mutant Uveal Melanoma
Authors: Sajjad Waseem
Published: January 2025

Dear editor
This letter highlights the promising nature of spliceosome inhibitor E7107 in SF3B1 mutant uveal melanoma and warrants future research to establish its clinical application, safety, and efficacy for these patients.
Uveal melanoma originates from the melanocyte of the uvea and has a metastasis rate of about 25-34% within a span of ten years leading to poor prognosis and a death rate of 80% at 1 year following metastasis.1 This shows the horrible nature of these melanomas and demand for an inevitable urge of definitive treatment options for these patients. However, unfortunately, the treatment options are very limited and poor. Various prognostic factors have been identified for uveal melanoma including mutations in genes encoding BRCA-1 associated protein (BAP1) being worst, splicing factor 3b subunit 1 (SF3B1) being intermediate, and eukaryotic translation initiating factor 1A X-linked (EIF1AX) being best prognostic factor.2,3A large percentage of about 15%-35% of uveal melanomas have SF3B1 mutations which make it an important prognostic feature however there is no well-established pharmacological agent targeting or utilizing this major prognostic mutation as a therapeutic fortune. A recently introduced protein Tebetafusp though showed prolonged survival in metastatic carcinoma but available only for metastatic uveal melanoma
COMMUNITY LEGAL AWARENESS IN REGISTRATION OF LAND OWNERSHIP RIGHTS (STUDY AT THE ART/BPN OFFICE PADANGSIMPUAN)
Authors: Oloan Nur , Pohan Sarmadan , Padly Fajar
Published: January 2025

In this millennial era, having a land certificate is very obligatory to avoid things that cause problems or cases regarding land. But with that, there are still people who do not have land certificates, even though this is  very important considering how easy it is to manipulate the certification system, as well as the legal awareness that the community has, especially in Padangmatinggi  Village,  Padangsidimpuani  City. So the problems that will be examined in this research are: What is the level of legal awareness of the community in registering their land? What are the obstacles and support factors faced by the community in registering their land? This research is included in the Empirical research typology. The data were collected in two ways, namely interviews and filling out questionnaires and analyzed qualitatively and using the statutory approach and applicable legal principles which became  the benchmark in determining public legal awareness. Data from the field were obtained through discussion and through electronic media that focused on the problem. The results of this study show that the community's legal awareness in registering their land is still lacking, there are still many people who do not understand the procedures and legal rules that apply to registering their land. This is prone to conflict conflict and forgery of certificate deeds. The local government must be more active in accelerating land certification, because if the program has been implemented without prior  socialization, most people will not know it.
ATUALIDADES DOS PRINCIPAIS TRATAMENTOS NA PERIIMPLANTITE: UMA REVISÃO DE LITERATURA
Authors: De Souza Fillipe Pontes , Cruz Roberto Machado , Nogueira Bella Ana Paula Granja Scarabel , Ferreira Marcio Salles , Campos Myllena Serpa , Da Silva Junior Daniel Pereira , Lopes de Oliveira João Pedro , Vitale Marcelo , Barbosa de Araújo Rodrigo Ricco Teixeira , Miquelante Adriano Antunes , De Oliveira Junior Nery José , catanho bezerra Tayná Soares , Galani Gabriel Marchiori , Reis de Freitas Yasmim Christynne Oliveira , Servin Gonzalez Juan Guillermo , Cavalcanti Cássio Francisco , Sa de Carvalho Jamila Maria , Xavier Lima Matheus de Freitas , aranha neto Idalisio Soares , Soares Morales Luis Gustavo
Published: January 2025

A mucosite peri-implantar e a periimplantite são condições inflamatórias relacionadas a implantes dentários. A mucosite, reversível, afeta a mucosa peri-implantar, enquanto a periimplantite causa perda óssea e pode levar à falha do implante. Tratamentos conservadores incluem antissépticos (clorexidina), laserterapia, antimicrobianos tópicos, probióticos e corticosteroides, além de educação em higiene bucal. A prevenção é baseada em protocolos personalizados, produtos inovadores e monitoramento regular. Nos casos avançados, tratamentos cirúrgicos como desbridamento, regeneração tecidual guiada (ROG), enxertos gengivais e uso de fibrina rica em plaquetas (PRF) são indicados. Estratégias eficazes visam restaurar a saúde peri-implantar, melhorar a função e prevenir complicações.
PERFIL DEMOGRÁFICO E CLÍNICO DE 177 PACIENTES COM APENDICITE AGUDA NA SANTA CASA DE BELO HORIZONTE
Authors: De Almeida Barbosa Cirênio , Ennes Ferreira Cibele , Martins dos Santos Tannús Lucas , Luiz Vieira Tannús Cláudio , Henriques Soares de Faria Matheus , Leonel Carneiro  Artur , José da Cunha Adéblio , Augusto Aglio Carlos
Published: January 2025

Introdução: Este trabalho destaca a importância do estudo de apendicite aguda, abordando a relevância da análise demográfica e profissional na apresentação e manejo da doença. Objetivo: Explorar o impacto demográfico e social de 177 pacientes com apendicite aguda tratados na Santa Casa de BH entre 1990 e 2012. Método: Inclui a descrição dos procedimentos éticos seguidos, incluindo a adesão ao termo de consentimento informado e o processo de aprovação pela Plataforma Brasil para 23 casos específicos.Foram utilizadas as plataformas Google Scholar , PubMed e Portal Regional da BVS. Discussão: Os resultados encontrados foram correlacionados  com as características demográficas e profissionais dos pacientes.A interação entre fatores demográficos, como profissão, etnia e gênero, e a incidência de diferentes tipos de apendicite foi complexa. A análise profissional mostrou uma alta incidência de apendicite entre atendentes de telemarketing, sugerindo uma possível ligação entre a natureza sedentária do trabalho e o risco de desenvolvimento de apendicite. Os sinais físicos, como o sinal de Blumberg e o sinal de Rovsing, foram prevalentes e fundamentais na confirmação diagnóstica, reforçando a importância de um exame físico detalhado. Conclusão: Essa observação abre caminho para uma avaliação mais aprofundada sobre como longos períodos de inatividade ou estresse ocupacional podem afetar a saúde gastrointestinal. Avaliação das repercussões dos resultados aponta  para métodos futuros de diagnóstico e tratamento da apendicite aguda.
PEMANFAATAN TEKNOLOGI INFORMASI DALAM PENGUATAN KEMAMPUAN RISET ILMIAH DI SEKOLAH
Authors: Prianto Cahyo , Maryana Diana , Andarsyah Roni
Published: January 2025

Guru memiliki peran sentral dalam proses pendidikan. Dalam kesehariannya, guru tentunya menemukan banyak permasalahan yang dihadapi dilapangan. Permasalahan yang ditemukan tersebut tentu dapat diselesaikan dengan pendekatan sebuah riset. Objek dari kegiatan PKM ini adalah guru-guru di MA Multiteknik Asih Putera yang dilaksanakan pada tanggal 12 Juni 2024 dan 13 Juli 2024. Tujuan dari kegiatan PKM ini adalah Memberikan penguatan kemampuan riset seperti pengetahuan dan keterampilan teknis yang diperlukan sesuai dengan kaidah riset dan meningkatkan keterampilan riset di era digital ini dengan memanfaatkan teknologi informasi. Metode pelaksanaan menggunakan 3 tahap yaitu FGD, Workshop 1 dan workshop 2. Hasil dari kegiatan PKM ini telah berhasil meningkatkan pengetahuan dan keterampilan teknis yang diperlukan sesuai dengan kaidah riset serta berhasil meningkatkan pengetahuan keterampilan riset dengan memanfaatkan teknologi informasi. Keberhasilan ini terlihat dari tiga hasil evaluasi yaitu hasil Evaluasi Peningkatan level keberdayaan mitra terdapat peningkatan pengetahuan sebesar 26% antara sebelum dan sesudah pelatihan. Evaluasi keterserapan materi dengan hasil rata-rata 83% responden tertarik dengan materi yang disajikan. Dan evaluasi penyelenggaraan kegiatan dimana rata-rata 83% responden menilai positif
ПОВЫШЕНИЕ ТОЧНОСТИ КРАТКОСРОЧНОГО ПРОГНОЗИРОВАНИЯ НАГРУЗКИ С ИСПОЛЬЗОВАНИЕМ АНСАМБЛЕВЫХ МОДЕЛЕЙ И ПОГОДНЫХ ДАННЫХ
Authors: ВАСЕНИН Д.Н. , ПОДВАЛЬНЫЙ С.Л. , САВВИН Н.В.
Published: January 2025

Точное краткосрочное прогнозирование электрической нагрузки играет решающую роль в эффективном управлении энергопотреблением и обеспечении стабильности энергосетей. В данной статье представлен передовой ансамблевый подход, который улучшает точность краткосрочного прогнозирования нагрузки путем интеграции случайного леса (RF) и градиентной регрессии на основе гистограмм (HGBR). Ансамблевый метод сочетает сильные стороны каждого алгоритма, позволяя захватывать сложные закономерности и взаимодействия в данных. Для придания практической значимости, модель была протестирована на реальных данных энергетической системы Университета Брешии, Италия, собранных с помощью специализированной системы мониторинга. Дополнительно в модель были включены внешние погодные компоненты, в частности, температура окружающей среды, что позволило значительно повысить точность прогнозирования. Результаты экспериментов показывают, что предложенная ансамблевая модель существенно превосходит отдельные методы по ряду показателей, достигая более высокой точности и надежности в прогнозировании электрической нагрузки. Включение температуры окружающей среды в качестве внешней переменной продемонстрировало значительное повышение производительности, что подчеркивает важность учета погодных факторов в задачах прогнозирования нагрузки.

Accurate short-term forecasting of electrical load plays a crucial role in efficient energy management and ensuring the stability of power grids. This paper presentsan advanced ensemble approach that improvesthe accuracy of short-term load forecasting by integrating random forest (RF) and histogram-based gradient regression (HGBR). The ensemble method combines the strengths of each algorithm, allowing you to capture complex patterns and interactions in the data. To give practical significance, the model was tested on real data from the energy systemof the University of Brescia, Italy, collected using a specialized monitoring system. Additionally, the model included external weather components, in particular, ambient temperature, which significantly improved the accuracy of forecasting.The experimental results show that the proposed ensemble model is significantly superior to individual methods in a numberof indicators, achieving higher accuracy and reliability in predicting electrical load. The inclusionof ambient temperature asan external variable demonstrateda significant increase in productivity, which underscoresthe importance of taking weather factors into account in load forecasting tasks.
ЛАНТАНОИДЫ: ПРИМЕНЕНИЕ В ПРОМЫШЛЕННОСТИ
И ВОЗДЕЙСТВИЕ НА ОКРУЖАЮЩУЮ СРЕДУ
Authors: Дешиев М.-Э.М. , Ахмадова Х.В. , Мутузова М.Х.
Published: January 2025

В статье показано промышленное использование редкоземельных элементов и приведен анализ влияния редкоземельных элементов на окружающую среду. Лантаноиды являются новыми загрязняющими веществами, поскольку в настоящее время не регулируются в отношении людей и экосистемы, являются микрозагрязнителями с очень низкими пределами обнаружения. Основной проблемой оценки влияния и риска для окружающей среды является установление связи между вредным воздействием загрязняющих веществ, в том числе и лантаноидов, и биологическим воздействием на всю экосистему и их экологическими последствиями.