bluuebunny/crossref_metadata_2025 huggingface dataset:
Poststroke activity engagement in community dwellers: Association with illness perceptions and perceived environment
Authors: Shi Yun , Howe Tsu-Hsin , Halpin Peter F , Wu Bei
Published: July 2022

Objectives

To investigate whether individuals’ poststroke activity engagement is associated with their perceptions of stroke, as well as their perceptions of physical and social environment.

Design

Cross-sectional study.

Setting

Participants were recruited from eight rehabilitation settings in Beijing, China.

Participants

A total of 202 dyads of community dwellers with stroke and their primary caregivers.

Main Measures

Activity engagement measured by the Assessment of Life Habits; stroke individuals’ and caregivers’ illness perceptions measured by the Stroke-Specific Illness Perceptions Questionnaire – Revised; and stroke individuals’ perceived social and physical environment measured by the Social Support Survey and abbreviated Neighborhood Environment Walkability Scale.

Results

A total of 202 dyads of individuals with stroke and their caregivers participated in the study with mean ages of 61.3 (8.3) and 52.6 (11.6), respectively. On average, stroke individuals scored 7.61 (1.42) on the daily activities subscale, indicating that they completed personal level activities without assistance but with some difficulty. They scored 6.21 (2.21) on the social roles subscale, suggesting that individuals completed societal level activities with assistive devices and with some difficulty. Illness perceptions correlated significantly with personal level activity engagement (change in R-squared = 0.029; p = 0.049), and perceived accessibility and heterogeneity correlated significantly with societal level activity engagement (change in R-squared = 0.025; p = 0.011).

Conclusions

Poststroke activity engagement is associated not only with stroke individuals’ performance skills but also with their perceptions of stroke, and how they perceive their physical environment. The findings may assist clinicians’ decision making when developing comprehensive, targeted interventions for improving activity engagement and maximizing recovery after stroke.
Class and race in Latin America’s left populist politics
Authors: Teichman Judith
Published: July 2022

This article challenges the notion that populist rhetoric in Latin America primarily and consistently arose in response to recent social dislocations and involves, from the onset, a Manichean struggle of the good people against an evil enemy. Instead, this work seeks the origins of polarisation, so often associated with populism, deep in history: in colonial conquest, in highly unequal economic, social and political relations in the post-independence period, and in nation-building myths that denied the existence of exclusions involving race/culture. Through an analysis of speeches given by former president of Argentina Juan Perón and former president of Venezuela Hugo Chávez, the author demonstrates a strong early conciliatory strain in populist rhetoric that calls for the respect and inclusion of racially and culturally distinct lower-class populist followers and acceptance of their importance to the nation. Initially, this rhetoric does not exclude the opposition in the populist leader’s concept of the nation. The Manichean aspect of populist rhetoric emerges later, when populist leaders come to believe that their pleas for material and cultural/racial inclusion have been and will always be rejected by anti-populists. In this interpretation, populism is a symptom of long-standing exclusion and latent pre-existing polarisation, not its cause.
Knowledge exchange and growth in a hybrid community – a social-capital-based approach: Evidence from Latvia
Authors: Sechi Guido , Šķilters Jurģis , Selecka Marta , Kalnača Līva , Leškēviča Krista
Published: July 2022

This article investigates patterns of knowledge exchange in hybrid communities where virtual and face-to-face links of communication are complementary. The study framework is based on social capital theory. The role of social capital dimensions and motivational factors in fostering the exchange of different forms of knowledge is investigated at an individual level. The proposed theoretical model is tested through structural equation modelling, and the analysis is carried out on a sample of over 250 individuals belonging to the community of users of the National Library of Latvia. The results confirm most of the theoretical hypotheses, but with some unexpected results– such as the relevant role of motivational factors in fostering the exchange of complex forms of knowledge– highlighting the specific nature of hybrid communities.
Improving Numeracy Skills in First Graders with Low Performance in Early Numeracy: A Randomized Controlled Trial
Authors: Lopez-Pedersen Anita , Mononen Riikka , Aunio Pirjo , Scherer Ronny , Melby-Lervåg Monica
Published: July 2022

Children with low performance in early numeracy are at risk of facing learning difficulties in mathematics, but few trials have examined how this can be ameliorated. A total of 120 first-grade children ( Mage = 6.4 years) were randomly assigned to an intervention or a control condition. The 14-week intervention targeted early numeracy skills and was delivered in small groups three times a week. Immediately after the initial 8-week intervention phase, moderate and positive effects were found on early numeracy ( d = 0.19), word problem solving ( d = 0.41), and approximate number sense ( d = 0.35). However, only the effects on word problems were significant, and all effects disappeared after the children undertook a second 6-week intervention phase. Overall, results indicate that (a) early numeracy skills are malleable in low-performing children, but (b) frequent and long-term interventions are needed for the positive effects to last.
Psychogenic Tics: Diagnostic Value of the Placebo Test
Authors: Tan Eng-King
Published: July 2022

Motor tics are characterized by abrupt onset of brief, unsustained focal movements that are usually preceded by a premonitory sensation and are suppressible. Psychogenic tics (pseudotics) are rarely described. It may not be easy to distinguish organic from functional tics because they can coexist. Using a case illustration, the value of a “staged” placebo test in aiding the diagnosis of psychogenic tics is described. In addition, a concise summary of the clinical phenomenology of tics and the diagnosis and management of psychogenic movement disorders is provided. (J Child Neurol 2004;19:976-977).
Invisible Room Attendants: Outsourcing as a Dispositive of (In)visibility and the Resistance of Las Kellys in Spain
Authors: Valenzuela-Bustos Alan , Gálvez-Mozo Ana , Alcalde-Gonzalez Verna
Published: July 2022

Outsourced room attendants have been described as invisible to both guests and management. However, room attendants in Spain have managed to create a movement called Las Kellys, which has raised their visibility and earned them respect in society. The article questions how outsourcing leads to the invisibility of room attendants in Spain and how Las Kellys renders them visible. Based on a study conducted with room attendants who were working at hotels in different parts of Spain in 2020, the results show how outsourcing works as a dispositive that creates invisibility through a socio-spatial and socio-legal segregation, while workers are seen as a number to be managed. Against the dispositive of invisibility, Las Kellys has raised their visibility as social actors to contest these ways of being (in)visible.
Contributions to reducing online gender harassment: Social re-norming and appealing to empathy as tried-and-failed techniques
Authors: Whiley Lilith A. , Walasek Lukasz , Juanchich Marie
Published: July 2022

Inspired by similar methods shown to be effective in reducing online racist harassment, we designed two tweets aimed at reducing online gender harassment. Our interventions were based on the principles of social re-norming and appealing to harassers’ empathy. In a sample of 666 Twitter users engaging in sexist or misogynist tweeting, we found that our intervention tweets did not reduce the number of sexist slurs or sexist users, either 7 days or 31 days after being sent. Our attempts also affected neither the valence nor the arousal of subsequent tweets posted by our sample of Twitter users. We discuss the conceptual, methodological, and ethical challenges associated with activist research aimed at reducing online gender harassment and discuss some of the implications of our attempts to do so.
Ursolic acid inhibits proliferation, migration and invasion of human papillary thyroid carcinoma cells via CXCL12/CXCR4/CXCR7 axis through cancer-associated fibroblasts
Authors: Cao Xianjiao , He Qingqing
Published: July 2022

As a pentacyclic triterpenoid compound, Ursolic acid (UA) broads range of biological effects. CXCL12 is a ligand for CXCR4 and CXCR7 proteins on thyroid cancer cells. Here we examined the effects of UA on the proliferation, migration and invasion of papillary thyroid carcinoma (PTCs) in a dose-manner. In addition, UA can reduce the expression levels of CXCR4 and CXCR7 in PTCs. In addition to this direct anticancer pathway, studies have shown that UA can play an anticancer role by affecting the secretion of CXCL12 in cancer-associated fibroblasts (CAFs). After treated with UA, normal fibroblasts and CAFs culture medium (CM) showed differential CXCL12 expression levels. We prepared fibroblast conditioned medium according to the intervention of UA, then cultured TPC-1 and B-CPAP cells with differential CM, and detected significant differences in the proliferation, migration and invasion of cancer cells. Our findings uncovered an indirect anticancer mechanism of UA. This cancer chemopreventive properties is expected to make UA a clinically useful chemopreventive agent.
Is Screen Addiction a Problem Among Rural School-Going Adolescents? A Cross-Sectional Study in South Karnataka
Authors: Johnson Avita Rose , Sridhar Pooja R. , Joseph Merlyn
Published: July 2022

Background:

Media, including mobile phones, computers, and social media, is a dominant force in the lives of adolescents, and has now penetrated the rural areas. Screen addiction (SA) is a pathological compulsive use of screen-based devices.

Objectives:

To estimate SA and its associated factors among school-going adolescents residing in a rural area in South Karnataka.

Methods:

A cross-sectional study was conducted among adolescents (10-19 years) in 4 schools of Solur Hobli, Ramanagara district, using a structured questionnaire including physical activity, family, and academic stressors. SA was assessed using Tao’s Diagnostic Criteria for Internet Addiction. Depression was screened using Physical Health Questionnaire-9. Chi-square test and logistic regression were done for factors associated with SA.

Results:

Of the 335 adolescents, 20% felt preoccupied with screens, 8% felt restless, moody, and irritable when not using them, 26% used screen devices as a way of escaping problems or relieving irritable mood, 12% had depression, and 3.9% had SA. SA was significantly higher among depressed subjects (adjusted odds ratio [AOR] = 5.18 [1.48-18.13], P = .010), males (AOR = 12.54 [1.46-109.9], P = .021), adolescents who felt that their parents fought frequently (AOR = 4.21 (1.17-15.09), P = 0.027), and adolescents who did not participate in sports (AOR = 3.82 (confidence interval: 1.04-14.06], P = 0.044).

Conclusion:

While proportion of rural students with SA is still low, we need to prevent this from developing into a public health issue by recognizing SA and depression among students and develop targeted interventions to manage the same, including increasing awareness among teachers and students about SA and its link with depression.
Indonesia Sustainable Tourism Resilience in the COVID-19 Pandemic Era: Case Study of Five Indonesian Super- priority Destinations
Authors: Wibowo Joshi Maharani , Hariadi Sugeng
Published: July 2022

This study was conducted to know Indonesia sustainable tourism resilience in the COVID-19 era. The research was done through a qualitative approach then analyzed based on the sentiment analysis and tourism resilience theory. The data used on this study are review data related to five super-priority tourism destinations in Indonesia, which are Borobudur Temple, Lake Toba, Labuan Bajo, Mandalika and Likupang since January 2020 to March 2021 from TripAdvisor. The result of this study shows that Indonesia sustainable tourism resilience during the pandemic COVID-19 era does not have strong enough resilience in facing the unstable recessions conditions and following new tourism trends that have emerged in the pandemic era or after the pandemic ends. This study provides two recommendations to overcome those problems: (a) Indonesia needs to develop local tourism activities based on the e-tourism concept and (b) the tourism activity must integrate with digitalization and local wisdom to create local common branding in the destination.
In Pursuit of Impact: From Research Questions to Problem Formulation in Entrepreneurship Research
Authors: Chen Suwen , Sharma Garima , Muñoz Pablo
Published: July 2022

In this paper, we address recent calls to increase the societal relevance of entrepreneurship research. We explore how entrepreneurship researchers and practitioners work together in the formulation of a research problem for impact. Leveraging process-tracing, we analyzed six entrepreneurship research projects, from early conceptualization to publication, all part of the Journal of Business Venturing Insights’ Entrepreneurship Rapid Response Research Initiative. We made two discoveries, as it pertains to the formulation of problems in entrepreneurship research. First, we found four critical change dimensions, along which a problem evolves throughout the research process: worthiness, divisibility, centrality, and specificity. Second, we found two equifinal problem formulation pathways in impact-oriented entrepreneurship research: inward-looking iterative and outward-looking joint problem formulation. These are marked by drivers of the research project, timing of involvement of the practitioner, and interactions between researchers and practitioners, which influence the sequence of the four change dimensions in problem formulation. Our study contributes by theorizing problem formulation as a process, not a point in time, and hence intertwined with solutions, making the process consequential. We also offer concrete implications for entrepreneurship scholars wanting to engage in research that impacts practice.
A Multilevel Review of Curvilinear Effects on the Creative Work of Teams
Authors: Razinskas Stefan
Published: July 2022

Their positive potential often diminishes or even turns negative when antecedents of creativity are taken too far. Despite empirical evidence supporting such curvilinear effects on important outcomes of creative work at the individual and team levels, their theorizing remains rather incomplete, with more attention being paid to explaining the curves’ upward rather than downward slopes. By developing a multilevel antecedent-benefit-cost (ABC) framework that synthesizes 120 quantitative-empirical studies on curvilinear effects, this review guides creativity and innovation literature toward conceptual clarity and methodological precision across levels. This is important because the cost-related mechanisms of certain antecedents are still not well understood.
The Esthetic Perception of Morphological Severity in Scaphocephalic Patients is Correlated With Specific Head Geometrical Features
Authors: Borghi Alessandro , Heutinck P. , Rodriguez-Florez N. , Koudstaal M. , Ruggiero F. , Ajami S. , Schievano S. , Jeelani N.U.O. , Dunaway D.
Published: July 2022

Objective

To investigate the relationship between perception of craniofacial deformity, geometric head features, and 3D head shape analyzed by statistical shape modeling (SSM).

Patients

A total of 18 unoperated patients with scaphocephaly (age  =  5.2  ±  1.1m)—6 were followed-up after spring-assisted cranioplasty (SAC) (age  =  9.6  ±  1.5m)—and 6 controls (age  =  6.7  ±  2.5m).

Main Outcome Measures

3D head shapes were retrieved from 3D scans or computed tomography (CTs). Various geometrical features were measured: anterior and posterior prominence, take-off angle, average anterior and posterior lateral and horizontal curvatures, cranial index (CI) (cranial width over length), and turricephaly index (TI) (cranial height over length). SSM and principal component analysis (PCA) described shape variability. All models were 3D printed; the perception of deformity was blindly scored by 9 surgeons and 1 radiologist in terms of frontal bossing (FB), occipital bulleting (OB), biparietal narrowing (BN), low posterior vertex (LPV), and overall head shape (OHS).

Results

A moderate correlation was found between FB and anterior prominence (r  =  0.56, P < .01) and take-off angle (r  =  − 0.57, P < .01). OB correlated with average posterior lateral curvature (r  =  0.43, P < 0.01) similarly to BPN (r  =  0.55, P < .01) and LPV (r  =  0.43, P < .01). OHS showed strong correlation with CI (r  =   − 0.68, P < .01) and TI (r  =  0.63, P< .01). SSM Mode 1 correlated with OHS (r  =  0.66, p < .01) while Mode 3 correlated with FB (r  =   − 0.58, P < .01).

Conclusions

Esthetic cranial appearance in craniofacial patients is correlated to specific geometric parameters and could be estimated using automated methods such as SSM.
Anti-histone H3.3K36M Antibody is a Highly Sensitive and Specific Immunohistochemistry Marker for the Diagnosis of Chondroblastoma. A Validation Based on Study 136 Cases Comprising Chondroblastoma and its Mimics from Single a Centre in India
Authors: Hui Monalisa , Uppin Shantveer G. , Narayanan Ramakrishna , Kancherla Nageshwar Rao , Kamble Anvesh , B Rajeev Reddy , Patnala Chandrashekar
Published: July 2022

Introduction. Chondroblastoma has a wide range of differential diagnosis encompassing various benign and malignant entities. The closest differential diagnosis is giant cell tumor of the bone due to overlapping radiological and histomorphological features. Extensive aneurysmal bone cyst like changes and lack of adequately sampled chondroid matrix often masquerades the primary bone lesion and amplifies the diagnostic difficulty in small biopsies with limited tissue. Immunohistochemistry is helpful in such instances to resolve the diagnostic dilemma. Objectives. To analyze the immunohistochemical expression of anti-histone H3F3K36M antibody inchondroblastoma and validate its utility in differentiating chondroblastoma from its histological mimics. Material and methods. Immunohistochemistry was performed using anti-histone antibody H3.3K36M in 44 histologically diagnosed chondroblastoma and 92 other histological mimickers. All chondroblastoma and giant cell tumor of the bone included in the study were also tested for anti-histone H3.3 G34W antibody. Of the 33 giant cell tumors of bone with classic morphology and imaging findings, 24 H3.3 G34W positive and 9 negative tumors were included intentionally to rule out the possibility of chondroblastoma. The sensitivity, specificity, positive and negative predictive value of marker with regard to chondroblastoma was calculated. Results. Immunohistochemistry revealed unequivocal nuclear positivity for H3.3K36M in the mononuclear cells in all the 44 chondroblastoma tested, denoting a sensitivity of 100% cases. Allthesetumors tested simultaneously for anti-histone H3.3G34W were negative. None of the histological mimickers were positive H3.3K36M indicating a specificity of 100%. The positive and negative predictive value was 100%. Conclusion. H3.3K36M mutant antibody is highly sensitive and specific IHC marker and can be used as a valuable adjunct to distinguish chondroblastoma from its histological mimics especially on small biopsies.
Early Entrance to Kindergarten? It Depends . . .
Authors: Hertzog Nancy B.
Published: July 2022

Entering kindergarten is one form of accelerating one’s path through schooling. The unique needs of young learners require policies for early entrance to kindergarten to be flexible, and options for parents to be accessible and equitable across school districts and communities. In this article, the author discusses state policies for early entrance to kindergarten, issues to consider when making decisions about enrolling one’s child into kindergarten early, and emphasizes the need to examine not only the child for indicators of readiness but also more importantly the environment in which the child is entering. Ideally, when considering early entrance into kindergarten, the child’s holistic needs would match the placement.
Rituximab biosimilar HLX01 versus reference rituximab in the treatment of diffuse large B-cell lymphoma: Real-world clinical experience
Authors: Deng Weishang , Yang Sensen , Yang Changyuan , Chen Haitao , Huang Guoning , Wu Hanbiao , Chen Jisheng
Published: July 2022

Introduction

HLX01 is the first rituximab biosimilar produced in China and the first monoclonal antibody biosimilar marketed in China. The purpose of this study was to comprehensively evaluate whether HLX01 is clinically consistent with the original drug based on real-world data to provide evidence for the clinical substitution of biosimilars in China.

Methods

A single-center retrospective study was conducted to select patients with diffuse large B-cell lymphoma who met the inclusion criteria and were treated with HLX01 or reference rituximab. Baseline characteristics, efficacy and safety results were recorded, and the corresponding statistical analysis was performed for various indicators.

Results

Thirty-three patients diagnosed with diffuse large B-cell lymphoma were included and divided into two groups that received HLX01 or reference rituximab. The results showed no significant difference in the overall response rate (86.7% vs. 88.9%; p = 1.000) or complete response rate (46.7% vs. 55.6%; p = 0.889) between the two groups. Kaplan–Meier survival curves also showed no significant difference in time-to-event variables between the two groups (log-rank = 0.244). Safety was also comparable in both groups.

Conclusions

HLX01 is a suitable replacement for reference rituximab in the treatment of diffuse large B-cell lymphoma and is relatively inexpensive, thereby reducing the economic burden of patients. Nevertheless, the conclusion of this study still needs to be further validated by large-sample real-world data and explored for HLX01 in other indications, such as follicular lymphoma.

Clinical trial registration

Not applicable.
Examining Sexual Crime Severity in China: A General-Specific Model on Sex Offending Against Adults
Authors: Zhou You , Xu Boyang , Sun Ivan Y. , Zhang Yan , Chang Lennon Y. C.
Published: July 2022

Sexual violence severity has long been viewed as a critical factor of sex offending. However, the criminological viewpoints on sexual violence severity have not received much attention, especially in the Chinese context. By integrating general-criminogenic (inhibitory mechanisms) and specific sex offending (learning mechanisms and contextual factors) perspectives, the current study links the propositions of social control (bonds) theory, self-control theory, differential association theory, and the integrated theory of sex offending, proposing a general-specific model for sexual violence severity. Survey data was collected from 250 Chinese offenders who committed sexual offenses against adults. The mediation analysis found that deviant peer association fully mediates the effects of social control and low self-control on sexual violence severity. The moderation analysis showed that substance abuse exaggerates the impact of deviant peer association on sexual violence severity, while sex purchasing mitigates this relationship. This general-specific model may expand our current understanding of sexual violence severity from both criminological and psychological perspectives.
When Does Information Transparency Reduce Downside of Personalization? Role of Need for Cognition and Perceived Control
Authors: Lambillotte Laetitia , Bart Yakov , Poncin Ingrid
Published: July 2022

Companies increasingly use personalization to offer a better experience to their customers. Online personalization enables them to learn from customers’ data and adapt their website content accordingly. Although customers may value personalization, it may also trigger privacy concerns. In this context, both regulators and firms need a better understanding of the process underlying the effect of personalization on privacy concerns, as well as the role of information transparency in this process. Drawing on signaling theory, the authors propose how perceived control may mediate the negative impact of personalization on privacy concerns and hypothesize that the interaction effect of personalization and information transparency depends on customer need for cognition. Findings from two experimental studies show that perceived control is lower on personalized websites than on nonpersonalized websites, which leads to privacy concerns. However, the presence of a transparency message can mitigate the negative effect of website personalization for customers who are in low need for cognition.
Challenges to the delivery of clinical diabetes services in Ghana created by the COVID-19 pandemic
Authors: Tagoe Eunice Twumwaa , Nonvignon Justice , van Der Meer Robert , Megiddo Itamar , Godman Brian
Published: July 2022

Objective

The barriers to delivering clinical non-communicable disease services in low- and middle-income countries have risen with the onset of COVID-19. Using Ghana as a case study, this article examines the changes COVID-19 has brought to diabetes service delivery and considers policy responses to deal with future such outbreaks.

Methods

We conducted 18 interviews between November 2020 and February 2021 with health professionals and administrators from primary, secondary and tertiary facilities within the Ghana Health Service. The analysis was performed using deductive and inductive methods.

Results

There were six general themes in interviewees’ responses: (1) COVID-19 had exacerbated the problems of high medicine and service costs and medicine shortages, (2) the pandemic had exacerbated problems of poor patient record keeping, (3) COVID-19 had reduced the availability of suitably trained health providers, (4) staff had become demoralized by management’s unwillingness to make innovative changes to cope with the pandemic, (5) COVID-19 led to a reorganization of diabetes services, and (6) the country’s national health insurance scheme lacked flexibility in dealing with the pandemic.

Conclusions

Access to resources is limited in LMICs. However, our study highlights practical policy responses that can improve health providers’ response to COVID-19 and future pandemics.
How COVID-19 is (and is not) changing the way we talk about sex and dating: A critical analysis of sex advice during the pandemic
Authors: Hindes Sophie , Urry Kristi
Published: July 2022

In this article, we applied a ‘sex critical’ lens to discursively analyse online sex advice available to Australian readers in the first 3 months of ‘lockdown’ during the COVID-19 pandemic (March–June 2020). We explored how sex and intimacy were being talked about within the pandemic context, examining if and how this was different to pre-pandemic sex advice. We found both the perpetuation of dominant discourses that limit understandings of sex and sexual practices, and challenges to these which open exciting possibilities for new sexual intimacies.
Literacy learning in infant-toddler programs: Practice architectures as a lens for examining educator pedagogy
Authors: Rouse Elizabeth , Nicholas Maria
Published: July 2022

The ‘schoolification’ of early childhood education and care programs, seen as readying children for formalised schooling, has had an impact on the education of younger and younger age groups. While the focus of past research has mainly focused on 4-5-year-old children, this study shifts the focus to 2-3-year-old children and the literacy focus of educators working with these very young children. Nine educators from Victoria, Australia were interviewed, asked to share their views on literacy learning and development for two-three-year-old children and the planning, assessment and practices they engage in to support children’s literacy development. Responses were analysed using a practice architectures lens. Findings showed that play-based pedagogies were often overlooked when seeking to support children’s literacy development, with a preference for more formalised foci on print-based learning activities, including a focus on alphabetic letter recognition. Implications for children’s literacy learning and practice are also discussed.
Bioanalytical method for estimation of procyclidine in human plasma using liquid chromatography-tandem mass spectrometry: Application to pharmacokinetic study
Authors: Bezawada Viritha , Mogili Padma , Dodda Sireesha , Gajula Ramakrishna
Published: July 2022

A rapid, selective and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for quantification of procyclidine hydrochloride in human plasma using Procyclidine D11 hydrochloride as internal standard. Liquid-liquid extraction technique with methyl tertiary butyl ether was used for the extraction of plasma samples. Chromatographic separation of the analyte and the internal standard from the endogenous components was done on Zodiac C18 column (50 × 4.6 mm, 5 µm) using a mixture of methanol and 0.1% formic acid in water (70:30, v/v) as mobile phase at a flow rate of 1 mL/min with the run time of 2 min. The detection of the eluents was done using multiple reaction monitoring (MRM) in positive ion mode. Linearity of the method was established in the concentration range of 0.5 to 120 ng/mL. Full validation of the method was done as per USFDA guidelines and the results were well within the acceptance limits. The successful application of the method was done on healthy human subjects under fasting conditions, proving it to be used for bioequivalence and bioavailability (BA/BE) studies of procyclidine.
Fast-Track Management of Concurrent Percutaneous Coronary Intervention in Patients Scheduled for Endovascular Abdominal Aortic Aneurysm Repair
Authors: Weng Chengxin , Wang Jiarong , Zhao Jichun , Ma Yukui , Huang Bin , Yang Yi , Yuan Ding , Wang Tiehao , Chen Xiyang
Published: July 2022

Purpose:

To investigate the safety and efficacy of fast-track management of concurrent percutaneous coronary intervention (PCI) in patients with abdominal aortic aneurysm scheduled for endovascular aortic aneurysm repair (EVAR).

Materials and Methods:

Eligible patients with abdominal aortic aneurysm who received EVAR from January 2011 to December 2019 were included in this retrospective cohort study. Propensity score (PS)–matched analysis was used to balance the baseline between the fast-track and standard control (EVAR without significant coronary artery disease) groups. Effects of fast-track management on short-term and midterm outcomes were evaluated via Cox proportional hazard regression and logistic regression analyses with corresponding hazard ratio (HR) or odds ratio (OR) and associated 95% confidence intervals (95% CIs), respectively.

Results:

The study included 669 patients (73 fast-track and 596 standard control). Compared with the standard control group, no significant difference was found regarding major adverse cardiac events (HR 0.78, 95% CI [0.36, 1.68], p=0.519), overall mortality (HR 0.63, 95% CI [0.25, 1.55], p=0.315), and 30-day major hemorrhage events (OR 1.01, 95% CI [0.99, 1.03], p=0.514). The results were consistent in the PS-matched cohorts regarding major adverse cardiac events (HR 0.57, 95% CI [0.25, 1.29], p=0.176), overall mortality (HR 0.43, 95% CI [0.17, 1.11], p=0.820), and 30-day major hemorrhage events (OR 1.00, 95% CI [0.05, 10.61], p=0.999). Similar results were found in the subgroup analyses concerning fast-track management of 2-week intervals and patients with high age-adjusted Charlson comorbidity index.

Conclusions:

Under appropriate perioperative care, shortening the time interval between PCI and EVAR to 1 month, or even 2 weeks, seemed to be safe and effective. Short-term and midterm cardiovascular and survival outcomes were comparable with patients who underwent standard EVAR without significant coronary artery disease.
What’s Compassionate Discipline Got to Do With It?
Authors: Brion Corinne
Published: July 2022

This teaching case study aims at encouraging meaningful conversations about discipline. The case illustrates the increasing need for school leaders to adopt discipline approaches that foster support, equity, inclusion, and advocacy for cultural differences rather than punishment and the exclusion of marginalized students. This scenario takes place in an urban middle school that is representative of many other American schools. In particular, I examine the challenges educational leaders commonly face with discipline, leading to unsatisfactory student learning outcomes and well-being. The hope is to expose school leaders to a holistic discipline approach that is grounded in support, care, love, and respect for cultural diversity. To promote reflection, I pose questions designed to prepare prospective and current educational leaders facing similar discipline situations.
Initial clinical experience with N-hexyl cyanoacrylate for neuroendovascular embolization
Authors: Goertz Lukas , Borggrefe Jan , Abdullayev Nuran , Celik Erkan , Pennig Lenhard , Timmer Marco , Lüers Jan-Christoffer , Schlamann Marc , Kabbasch Christoph
Published: July 2022

Objective

To report our initial clinical experience with N-hexyl cyanoacrylate (NHCA), a novel liquid agent for neurovascular embolization.

Methods

Four paragangliomas were treated with percutaneous embolization using NHCA as the sole embolic material. In one dural arteriovenous fistula (dAVF), NHCA was used in combination with other embolic materials. Procedural specifics, complications and angiographic results were retrospectively evaluated.

Results

Total or subtotal devascularization was obtained in 3 of the 4 paragangliomas. In the largest tumor, only partial devascularization could be achieved. The dAVF was completely occluded. Catheter entrapment did not occur. After dAVF treatment, the patient had an asymptomatic lacunar infarction, while there was no procedural morbidity related to paraganglioma treatment.

Conclusions

In this series, neurovascular embolization with NHCA was feasible and effective. It may be particularly beneficial for small and tortuous vessels that require low-profile catheterization and a slow and controlled polymerization. Further studies are necessary to prove the benefits of NHCA over established embolic agents.
Cognition in zero gravity: Effects of non-terrestrial gravity on human behaviour
Authors: Arshad Iqra , Ferré Elisa Raffaella
Published: July 2022

As humanity prepares for deep space exploration, understanding the impact of spaceflight on bodily physiology is critical. While the effects of non-terrestrial gravity on the body are well established, little is known about its impact on human behaviour and cognition. Astronauts often describe dramatic alterations in sensorimotor functioning, including orientation, postural control, and balance. Changes in cognitive functioning as well as in socio-affective processing have also been observed. Strikingly, no comprehensive theoretical model exists to outline the impact of non-terrestrial gravity on behaviour. Here, we have reviewed the key literature across the last 10 years and explored the impact of non-terrestrial gravity across three key functional domains: sensorimotor functioning, cognition, and socio-affective processing. We have proposed and preliminary validated a neurocognitive model to account for the effects of non-terrestrial gravity in these domains. Understanding the impact of non-terrestrial gravity on human behaviour has never been timelier and it will help mitigate against risks in both commercial and non-commercial spaceflight.
Analysis of the physiological response in junior tennis players during short-term recovery: Understanding the magnitude of recovery until and after the 25 seconds rule
Authors: Morais Jorge E , Bragada José A , Silva Rui , Nevill Alan M , Nakamura Fabio Y , Marinho Daniel A
Published: July 2022

Literature lacks evidence about the physiological recovery of tennis players between points. This study aimed to: (i) verify the heart rate (HR) and oxygen uptake (V̇O2) recovery variance in young tennis players from the end of a tennis drill until the 25-s mark and onwards (65-s limit), performed at several intensities, and (ii) test the curve fitting that better characterizes the players’ HR and V̇O2 recovery, from the end of the drill until the 65-s mark. The sample was composed of 13 male tennis players (age: 16.80 ± 1.61 years) recruited from a National Tennis Association. Players were instructed to perform a drill test (“two-line drill wide mode”) based on an intensity increment protocol. Three levels of intensity were used based on the reserve HR and V̇O2. A significance level effect was observed on the HRreserve and V̇O2reserve ( P < .001). At all three levels of intensity, the first 25 s were enough to significantly ( P < .001) recover the HRreserve and V̇O2reserve. The same significance trend ( P < .001) was maintained until the 65 s but with a lower magnitude over time. Overall, the HR and V̇O2 curve fitting indicated a cubic relationship at the three levels of intensity (except the V̇O2 at the first level). Considering the specific test performed, players significantly elicited their physiological profile for every additional 10 s (after the 25-s rule) in the three levels of intensity performed. Despite this being a drill test and not a competitive point, coaches, players, and tennis organizations should be aware of these findings.
Saikogenin F From Bupleurum smithii Ameliorates Learning and Memory Impairment via Antiinflammation Effect in an Alzheimer’s Disease Mouse Model
Authors: Chen Ze-Hui , Li Juan , Zhao Xun-Xia , Yang Xin-He , Li Jia , Zou Bin , Zang Wei-Biao , Ma Rui-Xia , Wang Ye-Feng , Yao Yao
Published: July 2022

Alzheimer's disease (AD) is the most common neurodegenerative disease associated with aging. Bupleurum smithii Wolff. is a Chinese folk medicine used to reduce fever and inflammation. Regarding the key role of neuroinflammation in AD pathogenesis, it was speculated that B. smithii may be the source of compounds that treat AD through anti-inflammatory effects. This study aimed to investigate the effects of saikogenin F, a natural active ingredient from B. smithii, on cognition impairment and neuroinflammation in AD mice induced by amyloid β (Aβ). The AD mice model was established by intracerebroventricular (i.c.v.) injection of Aβ, and different doses of saikogenin F (10, 20, and 40 mg/kg) were intragastrically administrated once daily. Results of behavioral experiments, including the novel object recognition (NOR) test, Y-maze test, and Morris water maze (MWZ) test, showed that saikogenin F could ameliorate Aβ-induced cognition impairment in AD mice. Enzyme linked immunosorbent assay (ELISA) results showed that tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), and reactive oxygen species (ROS) levels in hippocampal tissue increased after Aβ injection, while saikogenin F could significantly reduce the concentrations of these inflammatory factors. Western blotting results revealed that the Aβ-induced reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits protein expression in mice hippocampus was remarkably downregulated by saikogenin F. Results of Iba-1 immunohistochemical staining showed that saikogenin F could effectively inhibit Aβ-induced activation of microglia in vivo. These results suggested that saikogenin F could relieve Aβ-induced cognitive impairment via inhibiting neuroinflammation and microglial activation. These effects may be achieved by inhibiting the expression of the NADPH oxidase subunits gp91phox and p47phox.
High Levels of Akkermansia muciniphilia Growth Associated With Spring Water Ingestion Prevents Obesity and Hyperglycemia in a High-fat Diet-Induced Mouse Model
Authors: Kim Eui Jin , Sohn Tae Seo , Choi Hyun Ho , Oh Hui Yeong , Park Sang Ho , Cho Young-Chang , Jung Jin-Oh , Sohn Jeong Sun , Lee Hae Kyung , Choi Sung Sook , Chae Hiun Suk
Published: July 2022

Background: Type 2 diabetes may be alleviated by mineral water (MW) ingestion. We investigated whether spring water (SW) (a kind of mixed MW) ingestion influences metabolic parameters via alteration of the gut microbiota in high-fat diet (HFD)-fed mice. Method: We divided 32 C57/BL mice into 4 equal groups: normal diet with tap water (Control), high-fat diet with tap water (HFD), normal diet with SW (SW), and high-fat diet with SW (HFD + SW). During this experiment, we checked the body weight (BW) with fasting blood sugar (FBS) every week and all mice were sacrificed in the 17th week to observe serological markers, internal organs, and composition of gut microbiota. Results: The BW of HFD-fed mice was significantly higher than that of mice fed an HFD + SW diet in the early period of the experiment. Fasting blood glucose (FBG) in the HFD group showed a fluctuating pattern compared to the HFD + SW group, and the area under the curve (AUC) value of the oral glucose tolerance test (OGTT) was significantly greater in the HFD group than in the HFD + SW group. Serologic markers were not significantly different between the HFD and HFD + SW groups. Histologically, the most severe fatty changes in the liver were observed in the HFD group. Lastly, the gut levels of Akkermansia muciniphilia were 100-fold higher in the HFD + SW group than in the HFD mice. Conclusion: These findings indicate that SW ingestion, and the associated high levels of A muciniphilia growth in the gut, may improve the early stage of obesity and ameliorate HFD-induced hyperglycemia.
Moral Expansiveness Around the World: The Role of Societal Factors Across 36 Countries
Authors: Kirkland Kelly , Crimston Charlie R. , Jetten Jolanda , Rudnev Maksim , Acevedo-Triana Cesar , Amiot Catherine E. , Ausmees Liisi , Baguma Peter , Barry Oumar , Becker Maja , Bilewicz Michal , Boonyasiriwat Watcharaporn , Castelain Thomas , Costantini Giulio , Dimdins Girts , Espinosa Agustín , Finchilescu Gillian , Fischer Ronald , Friese Malte , Gastardo-Conaco Maria Cecilia , Gómez Ángel , González Roberto , Goto Nobuhiko , Halama Peter , Jiga-Boy Gabriela M. , Kuppens Peter , Loughnan Steve , Markovik Marijana , Mastor Khairul A. , McLatchie Neil , Novak Lindsay M. , Onyekachi Blessing N. , Peker Müjde , Rizwan Muhammad , Schaller Mark , Suh Eunkook M. , Talaifar Sanaz , Tong Eddie M. W. , Torres Ana , Turner Rhiannon N. , Van Lange Paul A. M. , Vauclair Christin-Melanie , Vinogradov Alexander , Wang Zhechen , Yeung Victoria Wai Lan , Bastian Brock
Published: July 2022

What are the things that we think matter morally, and how do societal factors influence this? To date, research has explored several individual-level and historical factors that influence the size of our ‘moral circles.' There has, however, been less attention focused on which societal factors play a role. We present the first multi-national exploration of moral expansiveness—that is, the size of people’s moral circles across countries. We found low generalized trust, greater perceptions of a breakdown in the social fabric of society, and greater perceived economic inequality were associated with smaller moral circles. Generalized trust also helped explain the effects of perceived inequality on lower levels of moral inclusiveness. Other inequality indicators (i.e., Gini coefficients) were, however, unrelated to moral expansiveness. These findings suggest that societal factors, especially those associated with generalized trust, may influence the size of our moral circles.
Two-year retrospective cohort results on use of a dynamic unilateral brace for treatment of clubfoot: Can compliance and prevention of recurrence both be achieved?
Authors: Farrar Emily J , Lo Michelle , Groothoff Luke , Cunningham Jerald , Theuri Joseph
Published: July 2022

Objectives

The Ponseti method has led to vast improvements in outcomes for infants born with clubfoot deformity, but challenges with compliance during the bracing phase of the protocol remain. Unilateral braces promise higher compliance but often have led to unacceptably high recurrence.

Methods

We have developed a novel unilateral brace for clubfoot deformity that strategically applies patient-specific, anatomically-targeted forces to the lower limb to maintain correction. We retrospectively reviewed the cases of 26 patients with minimum follow-up of 24 months. The data were analyzed for recurrence rates, caregiver-reported compliance, and differences in Pirani score, dorsiflexion, abduction, hindfoot eversion, and resting rotation between initial and final follow-up.

Results

Most patients ( N = 23, 88%) were compliant with the bracing protocol. Two patients showed recurrence of deformity (8%). There were statistically significant improvements in Pirani score, dorsiflexion, abduction, hindfoot eversion, and resting external rotation. A subset of patients with sub-optimal correction at baseline showed improvement in all parameters across the course of bracing.

Conclusions

This novel unilateral brace for maintenance of clubfoot correction after Ponseti treatment demonstrates rates of recurrence rates and caregiver-reported compliance at 2 years of follow up that are comparable to outcomes with traditional bilateral foot abduction orthoses.
Review of Empirical Research on Leadership and Firm Performance
Authors: Ngoc Khuong Mai , Thanh Tung Do , Hoang Quoc Thai
Published: July 2022

This review aims to present a systematic review of empirical research on leadership and firm performance (FP) in order to synthesize the fragmented knowledge and propose a unifying framework for future research. To achieve this purpose, this research adopts systematic literature review methodology. A total of 60 empirical papers published during the period 2002 to 2021 was retrieved through exhaustive manual searches of online databases. A matrix table was developed to extract and organize information from the retrieved articles. The findings revealed four main key themes. First, the topic of leadership and FP has been mostly quantitatively examined in many countries and industries. Second, different leadership approaches have been found to ameliorate FP and transformational leadership remains the most commonly used approach. Third, innovation, learning, and culture were the most common mediators of the leadership-FP relationship. Fourth, support for innovation, competitive intensity, firm size, leaders’ trust, and justice orientation have been found to moderate the effect of leadership on FP.
Antiretroviral Treatment Sharing among Female sex Workers Living with HIV in eThekwini (Durban), South Africa: Drivers and Implications for Treatment Success
Authors: Rock Amelia , Comins Carly , Mulumba Ntambue , Young Katherine , Mcingana Mfezi , Guddera Vijayanand , Hausler Harry , Phetlhu Rene , Baral Stefan , Schwartz Sheree
Published: July 2022

In South Africa, 62% of female sex workers (FSW) are estimated to be living with HIV. Qualitative research indicates that FSW share antiretroviral therapy (ART) with peers to surmount treatment barriers. We quantitatively described ART sharing, its correlates, and its relationship with viral suppression (VS) among FSW living with HIV in eThekwini, South Africa. Among FSW on ART (n = 890), 30% ever shared (gave and/or received) ART. Sharing ART was more likely among those with higher levels of alcohol use, illicit drug use, depression severity, and physical/sexual violence in the adjusted model. There was a positive, dose-response relationship between number of pills given to peers in the last 30 days and VS likelihood (aPR: 1.05, 95% CI: 1.02, 1.08; p < 0.01). Giving pills may strengthen peer relationships, which may facilitate ART adherence. ART distribution through peer networks holds promise as a context-appropriate intervention for improving ART adherence among FSW in this setting.