bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring Design Optimization of Self-Compacting Mortars with Response Surface Methodology
Authors: Rocha Stéphanie , Ascensão Guilherme , Maia Lino
Published: September 2023

The ever-evolving construction sector demands technological developments to provide consumers with products that meet stringent technical, environmental, and economic requirements. Self-compacting cementitious mixtures have garnered significance in the construction market due to their enhanced compaction, workability, fluidity, and mechanical properties. This study aimed to harness the potential of statistical response surface methodology (RSM) to optimize the fresh properties and strength development of self-compacting mortars. A self-compacting mortar repository was used to build meaningful and robust models describing D-Flow and T-Funnel results, as well as the compressive strength development after 24 h (CS24h) and 28 days (CS28d) of curing. The quantitative input factors considered were A (water/cement), B (superplasticizer/powder), C (water/powder), and D (sand/mortar), and the output variables were Y1 (D-Flow), Y2 (T-Funnel), Y3 (CS24h), and Y4 (CS28d). The results found adjusted response models, with significant R2 values of 87.4% for the D-Flow, 93.3% for the T-Funnel, and 79.1% for the CS24h. However, for the CS28d model, a low R2 of 39.9% was found. Variable A had the greatest influence on the response models. The best correlations found were between inputs A and C and outputs Y1 and Y2, as well as input factors A and D for responses Y3 and Y4. The resulting model was enhanced, thereby resulting in a global desirability of approximately 60%, which showcases the potential for the further refinement and optimization of RSM models applied to self-compacting mortars.
Application of Biomineralization Technology in the Stabilization of Electric Arc Furnace Reducing Slag
Authors: Chen How-Ji , Lin You-Ren , Tang Chao-Wei , Hung Yi-Chun
Published: September 2023

The unstable substances in steel slag are the main substances that affect its stability, which limits the large-scale resource utilization of steel slag. Most of the current methods for stabilizing electric arc furnace (EAF) slag are time-consuming and cannot be completely stabilized. In view of this, this study aimed to explore the feasibility of microbial-induced calcium carbonate precipitation (MICP) technology for stabilizing EAF reducing slag, and this was to be achieved by using the reaction between carbonate ions and free calcium oxide (f-CaO) in reducing slag to form a more stable calcium carbonate to achieve the purpose of stabilization. The test results showed that, when the EAF reducing slag aggregates (ERSAs) were immersed in a Sporosarcina pasteurii bacteria solution or water, the f-CaO contained in it would react such that stabilization was achieved. The titration test results showed that the f-CaO content of the ERSAs immersed in the bacterial solution and water decreased. The expansion test results of the ERSAs that were subjected to hydration showed that the seven-day expansion of ERSAs after biomineralization could meet the Taiwan regulation requirement of an expansion rate less than 0.5%. The thermogravimetric analysis showed that both the experimental group and the control group might contain calcium carbonate compounds. The results of the X-ray diffraction analysis showed that the CaCO3 content in the ERSAs that were immersed in the bacterial solution was significantly higher than those that were immersed in water. Moreover, the compressive strength test results of concrete prepared with ERSAs showed that the compressive strength of the control group concrete began to decline after 28 days. In contrast, the experimental group concrete had a good stabilization effect, and there was no decline in compressive strength until 180 days. At 240 days, the surface cracks of the experimental group were particularly small, while the surface of the control group showed obvious cracks. These results confirmed that a mineralization reaction with S. pasteurii bacteria could be used as a stabilization technology for ERSAs.
Pressure Model Study on Synchronous Grouting in Shield Tunnels Considering the Temporal Variation in Grout Viscosity
Authors: Ma Jun , Sun Ao , Jiang Annan , Guo Naisheng , Liu Xiang , Song Jinliang , Liu Tiexin
Published: September 2023

The grout pressure in the shield tunnel tail void during synchronous grouting is the key to controlling ground settlement and restraining the segment. However, the circumferential, longitudinal, and radial distribution of grout pressure considering the temporal variation in grout viscosity has not been well explored yet. In this study, a theoretical model of grout pressure distribution and dissipation considering the temporal variation in Bingham grout viscosity was established. The simulation results of the pressure model were verified by field-measured data. The results showed that the radial and longitudinal distributions of grout pressure considering the temporal variation in grout viscosity were closer to the field-measured data. The impacts of the main parameters on the pressure distribution and dissipation were analyzed. Compared with the effect of the shield tail void thickness, tunnel radius and yield shear stress have greater effects on grout pressure during the circumferential filling phase. During the longitudinal and radial diffusion phases, the increase in soil porosity and permeability coefficient was conducive to grout diffusion. The increase in the grout viscosity reduces the pressure loss during the grout flow process. The results of this research can provide a theoretical basis for the grout design process in shield tunnels.
Field Experiments on 3D Groundwater Flow Patterns in the Deep Excavation of Gravel-Confined Aquifers in Ancient Riverbed Areas
Authors: Xu Na , Shi Yujin , Wang Jianxiu , Wu Yuanbin , Lu Jianshen , Zhou Ruijun , Huang Xinlei , Ye Zhenhua
Published: September 2023

In ancient riverbed areas, the hydro-geological conditions are extremely complex because of the cutting of ancient river channels during the sedimentary process. How to lower groundwater level in water-riched gravel-confined aquifer during deep excavation is vital for underground engineering. Groundwater flow patterns had to be understood during foundation pit dewatering. This paper presents a field case study conducted at the deep foundation pit of the Qianjiang Century City station on Hangzhou Metro Line 6, which is notable for its 52 m deep unclosed waterproof curtain. A total of 34 pumping wells were installed within the pit. During the tests, one well was subjected to a pumping well, while the others served as observation wells. The research included two sets of multi-depth pumping tests, which differed in terms of their filter lengths, aimed at investigating the flow pattern around pump wells and the roots of diaphragm walls. The study found that the use of longer filters, higher pump rates, and filters placed nearer to aquifer roofs enhances dewatering efficiency and minimizes impact on the surrounding geological environment. This paper introduces a novel concept known as the diaphragm wall–pumping well effect, which regulates the water head outside the pit and the subsidence, thereby optimizing the drawdown of the deep foundation pit with an unclosed waterproof curtain. The findings were applied in the foundation pit dewatering of Qianjiang Century City station, and the drawdown in and outside the pit was effectively controlled.
Thermal Stability of Oxidation-Resistant Ta-Zr-Si-B-N and Ta-Zr-Si-B-C Coatings under In Situ TEM Heating and Vacuum Annealing
Authors: Sytchenko Alina D. , Loginov Pavel A. , Levashov Evgeny A. , Kiryukhantsev-Korneev Philipp V.
Published: September 2023

Amorphous Ta-Zr-Si-B-C and Ta-Zr-Si-B-N coatings were deposited by magnetron sputtering using a ceramic target in Ar + C2H4 and Ar + N2 reaction media. Thermal stability under in situ TEM heating, vacuum annealing and nanoindentation, as well as the effect of heating on structural-phase transformations in coatings and their mechanical characteristics, have been studied. The results showed that the heating of amorphous Ta-Zr-Si-B-C and Ta-Zr-Si-B-N coatings in a TEM column leads to precipitation h-TaSi2 and c-TaC crystalline phases at a temperature of 600 °C and h-Ta5Si3 and c-TaN at a temperature of 1000 °C, respectively. Similar structural-phase transformations were revealed as a result of vacuum annealing. An increase in temperature from 20 to 1000 °C led to a decrease in the hardness of the carbon-containing coating from 21 to 16 GPa as a result of stress relaxation. For the Ta-Zr-Si-B-N coating at a temperature of 1000 °C, an increase in hardness was observed from 18 to 27 GPa, which is associated with the crystallization of the coating, with the formation of a nanocomposite structure with h-Ta5Si3 and c-TaN crystallites of 6–10 nm in size and an a-Si(Zr,B)N amorphous region.
MDAU-Net: A Liver and Liver Tumor Segmentation Method Combining an Attention Mechanism and Multi-Scale Features
Authors: Ma Jinlin , Xia Mingge , Ma Ziping , Jiu Zhiqing
Published: September 2023

In recent years, U-Net and its extended variants have made remarkable progress in the realm of liver and liver tumor segmentation. However, the limitations of single-path convolutional operations have hindered the full exploitation of valuable features and restricted their mobility within networks. Moreover, the semantic gap between shallow and deep features proves that a simplistic shortcut is not enough. To address these issues and realize automatic liver and tumor area segmentation in CT images, we introduced the multi-scale feature fusion with dense connections and an attention mechanism segmentation method (MDAU-Net). This network leverages the multi-head attention (MHA) mechanism and multi-scale feature fusion. First, we introduced a double-flow linear pooling enhancement unit to optimize the fusion of deep and shallow features while mitigating the semantic gap between them. Subsequently, we proposed a cascaded adaptive feature extraction unit, combining attention mechanisms with a series of dense connections to capture valuable information and encourage feature reuse. Additionally, we designed a cross-level information interaction mechanism utilizing bidirectional residual connections to address the issue of forgetting a priori knowledge during training. Finally, we assessed MDAU-Net’s performance on the LiTS and SLiver07 datasets. The experimental results demonstrated that MDAU-Net is well-suited for liver and tumor segmentation tasks, outperforming existing widely used methods in terms of robustness and accuracy.
2D-Unitary ESPRIT Based Multi-Target Joint Range and Velocity Estimation Algorithm for FMCW Radar
Authors: Wen Dan , Yi Huiyue , Zhang Wuxiong , Xu Hui
Published: September 2023

Millimeter-wave FMCW radar has been widely used in joint range-velocity estimation of multiple targets. However, most existing algorithms are unable to estimate the range-velocity information with high accuracy simultaneously and fail to discriminate the targets with either closely spaced ranges or closely spaced velocities in the 2D range-Doppler spectrum. In order to deal with these problems, this paper proposes a 2D-Unitary ESPRIT-based joint range and velocity estimation algorithm of multiple targets for FMCW radar. Firstly, The 1D-IF signal is constructed into a 2D virtual array signal, the virtual array signals are preprocessed by a 2D-spatial smoothing technique to generate a new matrix signal. Then, according to the 2D-Unitary ESPRIT algorithm, the 2D real-valued information of the target parameters is obtained from this matrix signal, and then a new complex-value matrix is constructed. Finally, the eigenvalue decomposition of this new complex-value matrix is performed, and the range-velocity estimates of multiple targets are, respectively, calculated from the real and imaginary parts of the eigenvalues, and paired automatically. The simulation results illustrate that the proposed algorithm not only provides highly accurate range-velocity estimates but also has high-resolution performance and achieves automatic pairing of the range-velocity estimates in multi-target scenarios, thus effectively improving the multi-target joint range and velocity estimation performance of FMCW radar.
Composition Characteristics of VOCs in the Atmosphere of the Beibei Urban District of Chongqing: Insights from Long-Term Monitoring
Authors: Luo Shixu , Hao Qingju , Xu Zhongjun , Zhang Guosheng , Liang Zhenghao , Gou Yongxiang , Wang Xunli , Chen Fanghui , He Yangjian , Jiang Changsheng
Published: September 2023

Reducing anthropogenic volatile organic compounds (VOCs) is the most effective way to mitigate O3 pollution, which has increased over the past decades in China. From 2012 to 2017, special stainless-steel cylinders were used to collect ambient air samples from the urban area of Beibei district, Chongqing. Three-step pre-concentration gas chromatography–mass spectrometry was used to detect the collected air samples. The composition, concentration, photochemical reactivity, and sources of VOCs in Beibei were analyzed. During the observation period, the annual average VOC concentration was 31.3 ppbv, which was at an intermediate range compared to other cities in China. Alkanes (36.8%) and aromatics (35.6%) were the most abundant VOC groups, followed by halo-hydrocarbons (14.4%) and alkenes (12.6%). The overall trend of seasonal distribution of VOC concentration was high in summer and autumn, and low in winter and spring, with a statistically significant difference between summer and winter concentrations. The ozone formation potential (OFP) showed that alkenes were the most active species, followed by aromatics and alkanes, and summer was the season with the highest OFP (131.6 ppbv). Three major emission sources were identified through principal component analysis (PCA), i.e., vehicle exhaust emissions (66.2%), fuel oil evaporation (24.8%), and industrial sources (9.0%). To ameliorate the air quality within the study area, concerted efforts should be directed towards curtailing traffic emissions and mitigating the release of alkenes, particularly emphasizing more stringent interventions during the summer season.
Ratio-Type Estimator for Estimating the Neutrosophic Population Mean in Simple Random Sampling under Intuitionistic Fuzzy Cost Function
Authors: Ullah Atta , Shabbir Javid , Alomair Abdullah , Alomair Mohammed
Published: September 2023

Survey sampling has a wide range of applications in biomedical, meteorological, stock exchange, marketing, and agricultural research based on data collected through sample surveys or experimentation. The collected set of information may have a fuzzy nature, be indeterminate, and be summarized by a fuzzy number rather than a crisp value. The neutrosophic statistics, a generalization of fuzzy statistics and classical statistics, deals with the data that have some degree of indeterminacy, imprecision, and fuzziness. In this article, we introduce a fuzzy decision-making approach for deciding a sample size under a fuzzy measurement cost modeled by an intuitionistic fuzzy cost function. Our research introduces neutrosophic ratio-type estimators for estimating the population mean of the neutrosophic study variable YN∈[YL,YU] utilizing all the indeterminate values of the neutrosophic auxiliary variable XN∈[XL,XU] rather than only the extreme values XL and XU. Three simulation studies are carried out to explain the proposed methods of parameter estimation, sample size determination, and efficiency comparison. The results reveal that the proposed neutrosophic class of estimators produces more accurate and precise estimates of the neutrosophic population mean than the existing neutrosophic estimators in simple random sampling, which is the ultimate goal of inferential statistics.
What Determines the Class of Immunity an Antigen Induces? A Foundational Question Whose Rational Consideration Has Been Undermined by the Information Overload
Authors: Bretscher Peter
Published: September 2023

Activated CD4 T helper cells are required to activate B cells to produce antibody and CD8 T cells to generate cytotoxic T lymphocytes. In the absence of such help, antigens inactivate B cells and CD8 T cells. Thus, the activation or inactivation of CD4 T cells determines whether immune responses are generated, or potentially ablated. Most consider that the activation of CD4 T cells requires an antigen-dependent signal, signal 1, as well as a critical costimulatory signal, initiated when a pattern recognition receptor (PRR) engages with a danger- or pathogen-associated molecular pattern (DAMP or PAMP). Most also envisage that the nature of the DAMP/PAMP signal determines the Th subset predominantly generated and so the class of immunity predominantly induced. I argue that this framework is implausible as it is incompatible with diverse observations of the variables of immunization affecting the class of immunity induced. An alternative framework, the threshold hypothesis, posits that different levels of antigen mediated CD4 T cell interactions lead to the generation of different Th subsets and so different classes of immunity, that it is compatible with these observations. This alternative supports a rational approach to preventing and treating diverse clinical conditions associated with infectious disease and, more speculatively, with cancer.
The Role of NAD+ in Metabolic Regulation of Adipose Tissue: Implications for Obesity-Induced Insulin Resistance
Authors: Ruskovska Tatjana , Bernlohr David A.
Published: September 2023

Obesity-induced insulin resistance is among the key factors in the development of type 2 diabetes, atherogenic dyslipidemia and cardiovascular disease. Adipose tissue plays a key role in the regulation of whole-body metabolism and insulin sensitivity. In obesity, adipose tissue becomes inflamed and dysfunctional, exhibiting a modified biochemical signature and adipokine secretion pattern that promotes insulin resistance in peripheral tissues. An important hallmark of dysfunctional obese adipose tissue is impaired NAD+/sirtuin signaling. In this chapter, we summarize the evidence for impairment of the NAD+/sirtuin pathway in obesity, not only in white adipose tissue but also in brown adipose tissue and during the process of beiging, together with correlative evidence from human studies. We also describe the role of PARPs and CD38 as important NAD+ consumers and discuss findings from experimental studies that investigated potential NAD+ boosting strategies and their efficacy in restoring impaired NAD+ metabolism in dysfunctional obese adipose tissue. In sum, these studies suggest a critical role of NAD+ metabolism in adipose biology and provide a basis for the potential development of strategies to restore metabolic health in obesity.
Anti-Cancer Potential of Transiently Transfected HER2-Specific Human Mixed CAR-T and NK Cell Populations in Experimental Models: Initial Studies on Fucosylated Chondroitin Sulfate Usage for Safer Treatment
Authors: Chikileva Irina O. , Bruter Alexandra V. , Persiyantseva Nadezhda A. , Zamkova Maria A. , Vlasenko Raimonda Ya. , Dolzhikova Yuliya I. , Shubina Irina Zh. , Donenko Fedor V. , Lebedinskaya Olga V. , Sokolova Darina V. , Pokrovsky Vadim S. , Fedorova Polina O. , Ustyuzhanina Nadezhda E. , Anisimova Natalia Yu. , Nifantiev Nikolay E. , Kiselevskiy Mikhail V.
Published: September 2023

Human epidermal growth factor receptor 2 (HER2) is overexpressed in numerous cancer cell types. Therapeutic antibodies and chimeric antigen receptors (CARs) against HER2 were developed to treat human tumors. The major limitation of anti-HER2 CAR-T lymphocyte therapy is attributable to the low HER2 expression in a wide range of normal tissues. Thus, side effects are caused by CAR lymphocyte “on-target off-tumor” reactions. We aimed to develop safer HER2-targeting CAR-based therapy. CAR constructs against HER2 tumor-associated antigen (TAA) for transient expression were delivered into target T and natural killer (NK) cells by an effective and safe non-viral transfection method via nucleofection, excluding the risk of mutations associated with viral transduction. Different in vitro end-point and real-time assays of the CAR lymphocyte antitumor cytotoxicity and in vivo human HER2-positive tumor xenograft mice model proved potent cytotoxic activity of the generated CAR-T-NK cells. Our data suggest transient expression of anti-HER2 CARs in plasmid vectors by human lymphocytes as a safer treatment for HER2-positive human cancers. We also conducted preliminary investigations to elucidate if fucosylated chondroitin sulfate may be used as a possible agent to decrease excessive cytokine production without negative impact on the CAR lymphocyte antitumor effect.
Amyloid-Beta Peptides Trigger Premature Functional and Gene Expression Alterations in Human-Induced Neurons
Authors: Melo de Farias Ana Raquel , Pelletier Alexandre , Iohan Lukas Cruz Carvalho , Saha Orthis , Bonnefond Amélie , Amouyel Philippe , Delahaye Fabien , Lambert Jean-Charles , Costa Marcos R.
Published: September 2023

Alzheimer’s disease (AD) is the most prevalent cause of dementia in the elderly, characterized by the presence of amyloid-beta (Aβ) plaques, neurofibrillary tangles, neuroinflammation, synapse loss and neurodegeneration in the brain. The amyloid cascade hypothesis postulates that deposition of Aβ peptides is the causative agent of AD pathology, but we still lack comprehensive understanding of the molecular mechanisms connecting Aβ peptides to neuronal dysfunctions in AD. In this work, we investigate the early effects of Aβ peptide accumulation on the functional properties and gene expression profiles of human-induced neurons (hiNs). We show that hiNs acutely exposed to low concentrations of both cell-secreted Aβ peptides or synthetic Aβ1–42 exhibit alterations in the frequency of calcium transients suggestive of increased neuronal excitability. Using single-cell RNA sequencing, we also show that cell-secreted Aβ up-regulates the expression of several synapse-related genes and down-regulates the expression of genes associated with metabolic stress mainly in glutamatergic neurons and, to a lesser degree, in GABAergic neurons and astrocytes. These neuronal alterations correlate with activation of the SEMA5, EPHA and NECTIN signaling pathways, which are important regulators of synaptic plasticity. Altogether, our findings indicate that slight elevations in Aβ concentrations are sufficient to elicit transcriptional changes in human neurons, which can contribute to early alterations in neural network activity.
Career Education Skills and Career Adaptability among College Students in China: The Mediating Role of Career Decision-Making Self-Efficacy
Authors: Liu Xinqiao , Zhang Xinyuan , Dang Yiming , Gao Wenjuan
Published: September 2023

In the past, the shift in career patterns and the unprecedented disruptions caused by events such as COVID-19 have posed notable challenges for job seekers. This holds particularly true for college students who are preparing to enter the workforce. In this context, enhancing career adaptability plays a vital role in shaping their career development. The primary objective of this research was to investigate the relationship between career education skills and career adaptability among 273 undergraduate students in China. Additionally, the study aimed to explore the mediating effect of career decision-making self-efficacy in shaping this relationship. The findings of the correlation analysis indicate a significant positive correlation between career education skills and career adaptability. Moreover, the results of the mediation model revealed that career education skills significantly contribute to improving career adaptability along with the mediating effect of college students’ self-efficacy in making career decisions. This study suggests that universities should prioritize the development and expansion of career education initiatives. They should not only help establish clear career goals for college students but also cultivate a positive and flexible career outlook to assist them in better adapting to various changes that may arise throughout their career journeys.
Effect of an Artificial Sound-Based Index on the Perception of Historical Block Environments
Authors: Ye Jing , Chen Lingyan , Zheng Yushan
Published: September 2023

The acoustic environment can influence people’s perceptions and experiences and shape the soundscape. The soundscape has a unique role in shaping the cultural identity of a regional culture. Artificial sounds are an essential source of sounds in historical blocks; research has shown the influence of the ratio of perceived artificial sounds to the perceived extent of natural sounds on environmental perception in historical blocks. In order to explore this impact, this study uses the red soundscape index (RSIn), which represents the ratio of perceived artificial sounds to natural sounds, and constructs a structural equation model to elucidate the relationship between RSIn, soundscape perception, and sense of place. The results show that: (1) The evaluation of the sense of place is inversely related to the perception of artificial sounds and positively related to the perception of natural sounds. (2) Different artificial sounds have different effects on soundscape perception and the sense of place; the traditional culture soundscape index (TRSIn) has a significant impact on soundscape pleasantness (β = −0.13, p < 0.001) and soundscape quality (β = −0.09, p < 0.01). (3) The human soundscape index (ARSIn) has a significant impact on the sense of place (β = −0.14, p < 0.001). (4) The music soundscape index (MRSIn) has a significant negative impact on soundscape quality (β = −0.13, p < 0.05) and the sense of place (β = −0.12, p < 0.05). Therefore, the different dominant artificial sound sources should be considered and emphasized when designing and optimizing the soundscape of historic districts. The results of this study can serve as design guidelines and supporting data, providing a reference for the optimization and enhancement of the soundscape of historical blocks.
Early Age Performance of OPC-GGBFS-Concretes Containing Belite-CSA Cement Cured at Sub-Zero Temperatures
Authors: Kothari Ankit , Buasiri Thanyarat , Cwirzen Andrzej
Published: September 2023

This study determined how replacing sodium nitrate-based antifreeze admixture (AF) with belite-calcium sulfoaluminate (belite-CSA) cement affects the early age properties of ecological concretes based on ordinary Portland cement (OPC) and ground granulated blast-furnace slag (GGBFS). Concrete specimens were cured at −15 °C and treated in various ways before testing, i.e., no treatment, stored at 20 °C for 12 and 24 h. Generally, the addition of belite-CSA cement shortened the setting time due to the rapid formation of ettringite. The incorporation of 25 wt% of antifreeze admixture (AF) to the OPC-GGBFS concrete cured at −15 °C partially inhibited ice formation and enabled the continuation of hydration processes. This trend was observed for all samples, independent of the applied AF after freezing curing. On the contrary, the addition of 20 wt% of CSA failed to inhibit the ice formation and increased the risk of frost damage for concretes despite the treatment after freezing. These concrete specimens had lower hydration, lower strength, and a more porous binder matrix. The microstructure of the binder matrix was significantly affected by the amount of CSA and extreme negative curing, followed by no notable recovery post-curing at room temperature. Therefore, pre-curing at room temperature for at least 6 h has the potential to avoid frost damage. Concrete containing 25 wt% AF combined with 12 h and 24 h of curing at 20 °C after removal from freezing and prior to testing could enhance the compressive strengths of all concretes. The renewed hydration was indicated as the main influencing factor.
Pressure Optimization in Pneumatic Interfaces Using a Single-Bay Seven-Story Infilled Reinforced Concrete Frame: Experimental and Numerical Investigation
Authors: George Prem Kumar , Varatharajan Thirumurugan , Srinivasan Satyanarayanan Kachabeswara , Hakeem Ibrahim Y. , Özkılıç Yasin Onuralp
Published: September 2023

Reinforced concrete infilled frames have been studied over the years along with the infilled openings. To resist the lateral loads that are applied on the frames, stress is transferred from the reinforced concrete (RC) to infill, which leads to brittle collapse. The conventional interface medium, which was considered by researchers and recent studies, was prepared by changing the interface materials between the RC frame and infill panels to different elastic materials. This study focuses on optimizing the interface pressure using a butyl rubber tube, which reduces the stress distribution to the infill panel from the RC frame. A 50% window opening was adopted in this study, which is the optimized size from previous research. The optimization patterns followed linear and nonlinear patterns, such as the same pressures in all stories and varying pressures in all stories. The third story had a 8 PSI pattern and the other stories had a 2 PSI pattern; all stories with 8 PSI patterns achieved the least displacement when compared to other variations. A monotonic static analysis was performed for both the experimental and analytical study. The boundary conditions were pinned, and coupling interfaces were made for the master and slave surfaces. The pressure conditions were applied in various linear and nonlinear patterns to optimize the pressure. A comparative study was performed on the displacement, stiffness, and drift ratio for the critical position of the interface pressure in both the analytical and experimental studies. The difference was approximately 0.53% in the analytical study and 0.37% in the experimental work. The optimization was performed using both an experimental model and an analytical model, which had an error percentage of 0.61%.
Numerical Simulation Analysis of the Full-Section Immersed Tube with the Post-Pouring Belt under Hydration Reaction
Authors: Li Ping-Jie , Chen Ming-Jie , Sun Wen-Huo
Published: September 2023

To study the force and deformation characteristics of a full-section immersed tube with post-pouring belt under the action of hydration reaction, the numerical model of full-section immersed tube with post-pouring belt was established by using MIDAS FEA (V2013) finite element analysis software, and the stress, cracking and deformation of the segment of the post-pouring belt were analyzed. The results show that under the action of hydration reaction, the concrete reaches the highest temperature at about 36 h, which appears at the roof of the tube gallery in the immersed tube, and the bottom steel plate expands rapidly initially, and subsequently shrinks gradually. The outer surface of the post-pouring segment concrete is stretched, and the internal region is under pressure, and as the internal temperature of the concrete cools down, the bottom plate starts to contract. The steel bar connection between the post-pouring belt and the surrounding immersed tube segment will increase the risk of cracking in the bottom plate of the full-section immersed tube. When only the steel bars in the bottom plate are connected, the maximum tensile stress of the immersed tube bottom plate will increase by 16.0% compared to the no connection case. If the steel bars of the immersed tube’s web and roof are also connected, the maximum tensile stress will increase by over 20%. By connecting the steel bars, the peripheral tube section plays a certain role in limiting the transverse deformation of the post-pouring belt and constraining the reinforcement of the bottom plate and web (and roof) can reduce the transverse deformation of the immersed tube to a great extent, reducing the proportion by over 10%.
A Seismic Risk Assessment of Concrete-Filled Double-Skin Steel Tube (CFDST) Frames with a Beam-Only-Connection for Reinforced Concrete Shear Walls (BRWs)
Authors: Sun Hongyu , Hu Yi , Zhao Junhai , Wang Da , Liu Yi
Published: September 2023

The beam-only connected reinforced concrete shear wall (BRW) is used as a reinforcing component to enhance the seismic performance of concrete-filled, double-skin steel tube (CFDST) frames. The effects of the BRW on seismic risks of CFDST frames are investigated. Three performance levels of limit states are defined and described according to the typical failure of test specimens and the existing definition of current guidance. A simplified numerical model is calibrated for CFDST frame-BRW structures, and test results validate it. Nonlinear dynamic analyses on a nine-story CFDST-BRW building are performed to investigate the effects of BRW on reducing the seismic risk of CFDST buildings. The results show that the BRW reduces the probability of collapse of the CFDST frame to 2.76% in 50 years, which can effectively reduce the probability of different degrees of damage in the service cycle of the structure. The results provide information for risk-informed decision-making on the design of CFDST frame-BRW structures.
Venetoclax with Hypomethylating Agents in Newly Diagnosed Acute Myeloid Leukemia: A Systematic Review and Meta-Analysis of Survival Data from Real-World Studies
Authors: Ucciero Andrealuna , Pagnoni Federico , Scotti Lorenza , Pisterna Alessia , Barone-Adesi Francesco , Gaidano Gianluca , Patriarca Andrea , Lunghi Monia
Published: September 2023

In recent years, the association of venetoclax (VEN) with hypomethylating agents (HMAs) significantly improved the outcome of patients with newly diagnosed acute myeloid leukemia (AML) who were unfit for intensive chemotherapy and became the standard of care after the publication of the pivotal RCT VIALE-A. However, it is still not clear to what extent the results observed in the VIALE-A apply to a real-world setting. For this reason, we carried out a systematic review and meta-analysis of real-world studies on newly diagnosed patients with AML, ineligible for intensive induction chemotherapy, receiving first-line VEN+HMA. We then compared their results in term of survival with those from the VIALE-A. Kaplan-Meier curves were extracted from all included studies and individual survival data was reconstructed. We then estimated a pooled survival curve and compared it with the results of the VIALE-A using the log-rank test. We also conducted a secondary analysis including only studies considering VEN plus azacytidine (AZA) as treatment, as this was the schedule originally used in the VIALE-A. Nineteen real-world studies met the inclusion criteria and were included in the systematic review. Most of them reported a worse survival than the VIALE-A. The pooled survival curve was similar to that reported in the VIALE-A during the first three months of treatment but diverged thereafter (p-value = 0.0001). The pooled median survival among the real-world studies was 9.37 months (95%CI 8.81–10.5), substantially lower than that reported in the VIALE-A (14.7 months; 95%CI 11.9–18.7). Results slightly increased when the analysis was restricted to the studies using VEN+AZA as treatment (median survival: 11.5 months; 95%CI 10.2–14.8). Survival of newly diagnosed AML patients treated with VEN+HMAs in a real-world setting seems to be lower than previously reported in the VIALE-A, while the effect of VEN+AZA is more in line with expected results. Future studies are needed to evaluate whether this apparent discrepancy is due to the different characteristics of enrolled patients or to a non-optimal adherence to therapy, and whether alternative regimens can provide better results in terms of safety and effectiveness.
Novel Insights in the Genomics of Anaplastic Thyroid Carcinoma: A Role for Cyclin-Dependent Kinase Inhibition?
Authors: Stenman Adam , Juhlin Carl Christofer
Published: September 2023

Anaplastic thyroid carcinoma (ATC) stands as a rare but extraordinarily lethal tumor, marked by its limited treatment options [...]
Modern Stereotactic Radiotherapy for Brain Metastases from Lung Cancer: Current Trends and Future Perspectives Based on Integrated Translational Approaches
Authors: Levis Mario , Gastino Alessio , De Giorgi Greta , Mantovani Cristina , Bironzo Paolo , Mangherini Luca , Ricci Alessia Andrea , Ricardi Umberto , Cassoni Paola , Bertero Luca
Published: September 2023

Brain metastases (BMs) represent the most frequent metastatic event in the course of lung cancer patients, occurring in approximately 50% of patients with non-small-cell lung cancer (NSCLC) and in up to 70% in patients with small-cell lung cancer (SCLC). Thus far, many advances have been made in the diagnostic and therapeutic procedures, allowing improvements in the prognosis of these patients. The modern approach relies on the integration of several factors, such as accurate histological and molecular profiling, comprehensive assessment of clinical parameters and precise definition of the extent of intracranial and extracranial disease involvement. The combination of these factors is pivotal to guide the multidisciplinary discussion and to offer the most appropriate treatment to these patients based on a personalized approach. Focal radiotherapy (RT), in all its modalities (radiosurgery (SRS), fractionated stereotactic radiotherapy (SRT), adjuvant stereotactic radiotherapy (aSRT)), is the cornerstone of BM management, either alone or in combination with surgery and systemic therapies. We review the modern therapeutic strategies available to treat lung cancer patients with brain involvement. This includes an accurate review of the different technical solutions which can be exploited to provide a “state-of-art” focal RT and also a detailed description of the systemic agents available as effective alternatives to SRS/SRT when a targetable molecular driver is present. In addition to the validated treatment options, we also discuss the future perspective for focal RT, based on emerging clinical reports (e.g., SRS for patients with many BMs from NSCLC or SRS for BMs from SCLC), together with a presentation of innovative and promising findings in translational research and the combination of novel targeted agents with SRS/SRT.
Cardiac Progenitor Cell Exosomal miR-935 Protects against Oxidative Stress
Authors: Aguilar Susana , García-Olloqui Paula , Amigo-Morán Lidia , Torán José Luis , López Juan Antonio , Albericio Guillermo , Abizanda Gloria , Herrero Diego , Vales África , Rodríguez-Diaz Saray , Higuera Marina , García-Martín Rubén , Vázquez Jesús , Mora Carmen , González-Aseguinolaza Gloria , Prosper Felipe , Pelacho Beatriz , Bernad Antonio
Published: September 2023

Oxidative stress-induced myocardial apoptosis and necrosis are critically involved in ischemic infarction, and several sources of extracellular vesicles appear to be enriched in therapeutic activities. The central objective was to identify and validate the differential exosome miRNA repertoire in human cardiac progenitor cells (CPC). CPC exosomes were first analyzed by LC-MS/MS and compared by RNAseq with exomes of human mesenchymal stromal cells and human fibroblasts to define their differential exosome miRNA repertoire (exo-miRSEL). Proteomics demonstrated a highly significant representation of cardiovascular development functions and angiogenesis in CPC exosomes, and RNAseq analysis yielded about 350 different miRNAs; among the exo-miRSEL population, miR-935 was confirmed as the miRNA most significantly up-regulated; interestingly, miR-935 was also found to be preferentially expressed in mouse primary cardiac Bmi1+high CPC, a population highly enriched in progenitors. Furthermore, it was found that transfection of an miR-935 antagomiR combined with oxidative stress treatment provoked a significant increment both in apoptotic and necrotic populations, whereas transfection of a miR-935 mimic did not modify the response. Conclusion. miR-935 is a highly differentially expressed miRNA in exo-miRSEL, and its expression reduction promotes oxidative stress-associated apoptosis. MiR-935, together with other exosomal miRNA members, could counteract oxidative stress-related apoptosis, at least in CPC surroundings.
Design of DNA-Based Artificial Transmembrane Channels for Biosensing and Biomedical Applications
Authors: Xu Wanyu , Chen Hui , Li Yang , Liu Shuangna , Wang Kemin , Liu Jianbo
Published: September 2023

Biomolecular channels on the cell membrane are essential for transporting substances across the membrane to maintain cell physiological activity. Artificial transmembrane channels used to mimic biological membrane channels can regulate intra/extracellular ionic and molecular homeostasis, and they elucidate cellular structures and functionalities. Due to their program design, facile preparation, and high biocompatibility, DNA nanostructures have been widely used as scaffolds for the design of artificial transmembrane channels and exploited for ionic and molecular transport and biomedical applications. DNA-based artificial channels can be designed from two structural modules: DNA nanotubes/nanopores as transport modules for mass transportation and hydrophobic segments as anchor modules for membrane immobilization. In this review, various lipophilic modification strategies for the design of DNA channels and membrane insertion are outlined. Several types of DNA transmembrane channels are systematically summarized, including DNA wireframe channels, DNA helix bundle channels, DNA tile channels, DNA origami channels, and so on. We then discuss efforts to exploit them in biosensor and biomedical applications. For example, ligand-gated and environmental stimuli-responsive artificial transmembrane channels have been designed for transmembrane signal transduction. DNA-based artificial channels have been developed for cell mimicry and the regulation of cell behaviors. Finally, we provide some perspectives on the challenges and future developments of artificial transmembrane channel research in biomimetic science and biomedical applications.
Dietary Patterns of Children from the Amazon Region of Ecuador: A Descriptive, Qualitative Investigation
Authors: Murphy Kristin N. , Boyce Lisa K. , Ortiz Eduardo , Santos Marcela , Balseca Gloria
Published: September 2023

Many young children in Ecuador suffer from high rates of malnutrition and stunting that affect their long-term growth and development. Little is known about the dietary patterns of children from the Amazon region who experience some of the highest rates of stunting (height-for-age) within Ecuador. Semi-structured interviews were conducted with 50 mothers of young children living in the Ecuadorian Amazon. In addition to descriptions of overall dietary patterns, three themes emerged from the interviews relating to strengths mothers have in feeding their children healthy diets: knowledge, autonomous and independent children, and supportive and responsive parenting. Five themes were found relating to barriers mothers have in feeding their children healthy diets. The first four themes concerned barriers (lack of knowledge of healthy foods, lack of access to healthy foods, not enough money, and child’s health) related to multidimensional poverty. All these influenced the last theme found, namely, how difficult of an eater the child was. The implications of intervention efforts to reduce undernutrition and promote children’s development by building on specific family and community strengths and identified barriers are also discussed in this paper.
Capecitabine/Mitomycin versus 5-Fluorouracil/Mitomycin in Combination with Simultaneous Integrated Boost Intensity-Modulated Radiation Therapy for Anal Cancer
Authors: Mineur Laurent , Vazquez Léa , Belkacemi Mohamed , Toullec Clémence , Bentaleb Newfel , Boustany Rania , Plat Frederi
Published: September 2023

Since EXTRA, a non-randomized phase II trial with 31 patients, explored the use of capecitabine, mitomycin and radiation therapy (RT) in the treatment of localized squamous cell carcinoma of the anal canal (SCCAC), this treatment has been considered as an acceptable alternative to infusional 5-FU. However, the differences in efficacy between capecitabine and 5-FU in chemoradiation therapy (CRT) with simultaneous integrated boost (SIB) radiation therapy (SIB-IMRT) for local SCCAC are not well documented. Patients included in this prospective monocentric cohort study were treated with SIB-RapidArc (a unique RT method treatment for all patients: identical technique, volume and constraints for at-risk organs), mitomycin C and 5-FU each day of RT for 7 weeks (group 1) or capecitabine each day of RT (group 2). Patients treated between July 2009 and August 2017 (group 1) and between November 2012 and April 2018 (group 2) for local SCCAC T2-4 classified as N, M0 or T, N1-3, M0 were included. Primary endpoints were progression-free survival (PFS) and acute toxicities. Results: One hundred forty-seven patients were included, 91 in group 1 and 56 in group 2. The two groups were statistically comparable in terms of sex, Eastern Cooperative Oncology Group Performance Status (ECOG PS) and TNM. With a median duration of follow-up of 53.5 months, the PFS rate at 3 years was 80% for group 1 and 75% for group 2 (p = 0.32). The 3-year colostomy-free survival rate was 92% for group 1 and 85% for group 2 (p = 0.11). The rate of patients with at least one grade 3 or higher acute toxicity was 35.5% in group 1 and 21.4% in group 2 (p = 0.10), with a trend of fewer acute toxicities with capecitabine. Conclusion: Capecitabine/mitomycin in combination with SIB RapidArc radiation therapy for anal cancer seems as effective as 5-FU-based chemotherapy and is well tolerated with minimal toxicity.
Sarcoidosis with Severe Bone Involvement: A Case Report and Literature Review
Authors: Feng Haoshen , Ma Jiangwei , Zhao Yabin , Zheng Rui , Wang Wei
Published: September 2023

Sarcoidosis is a systemic granulomatous disease of the lungs that commonly involves intrathoracic lymph nodes. Here, we report the case of a 68-year-old woman who complained of shortness of breath and had suffered from the enlargement of intrathoracic lymph nodes for 12 years, swelling of the right middle finger for 7 years, and nasal obstruction for 2 years. The damage to the phalange was aggravated continuously and a malignant lesion could not be excluded, thus leading to amputation of the right middle finger. Pathological data indicated chronic inflammatory granulomatous disease and anti-acid staining was negative. Examination of the paranasal sinuses indicated destruction of the sinonasal bone and the swollen mucosa. Combined with the elevated ratio of CD4+/CD8+ T cells in bronchoalveolar lavage fluid and other results, the patient was finally diagnosed with sarcoidosis and received corticosteroid therapy. The shortness of breath and abnormality of the nose were significantly improved after treatment. Our case demonstrated the process of differential diagnosis for systemic granulomatous diseases, indicating the necessity of corticosteroid therapy for systematic sarcoidosis.