bluuebunny/crossref_metadata_2025 huggingface dataset:
Nutritional evaluation of functional biscuits supplemented with Malva nuts(Sterculia Lychnophora
Authors: Nguyen Van Toan  , Nguyen Ngoc Yen Chi
Published: April 2022

Malva nut or Sterculia lychnophora is a traditional medicine and is widely found in the Southeast Asia region and China. This traditional medicine is known to have good health effects and can act as a food additive to improve the texture of several food products as well as functional ingredients. In this study, nutritional evaluation of functional biscuits supplemented malva nuts (Sterculia lychnophora) was thoroughly and successfully investigated. Consequently, the crude malva nut powders were extracted by using two different solvents (water and ethanol) and were supplemented into biscuits at the level of 2.5%, 5%, 7,5%, and 10%. The physio-chemical determination and sensory evaluation were carried out to all the developed biscuits. Overall, supplementation of crude malva nut powder into biscuits significantly affects the nutritional values and physical properties of developed biscuits. On the nutritional basis, at the same level of supplementation, biscuits supplemented with water extracted crude malva nut powder showed higher fat content while biscuits made with ethanol extracted ethanol demonstrated higher ash, protein, fiber, and total carbohydrates contents, especially at 10% of supplementation. For the sensorial differences, except the 7.5%, biscuits with 2.5%, 5%, and 10% crude malva nut powders clearly unidentical. The obtained results of this study have indicated that the developed biscuits were not only improved in terms of nutritional value and health benefits, but also had high potential of being accepted by consumers.

Keywords: malva nut, Sterculia lychnophora, solvents, functional biscuits
Family Welfare and Work Ethos: The Role of Social Capital and Family Resources in North Timor District
Authors: Be Emanuel
Published: April 2022

This study aims to evaluate the effect of Social Capital and Family Resources on Work Ethic which leads to improving the welfare of underprivileged families in North Central Timor district based on the local wisdom of the Dawan community. With the work culture that is owned and the potential for family and kinship relationships as well as the trust that is fostered in the community, it is able to improve family welfare. This study uses a qualitative descriptive method with an associative approach to determine the correlation between variables. The results of the study indicate that: social capital and family resources each have an effect on work ethic. While the work ethic also affects the welfare of the family. The results of this study also found that: social capital and family resources have an influence on family welfare if there is an increase in the work ethic of underprivileged families.
Humanism and the Urban Spaces in Meja Mwangi’s Novels
Authors: Martha Flavian Ombati,
Published: April 2022

Humanism is a conscious awareness and reciprocal actions of being humane. An individual’s efforts to be humane and to realize fully their own humanity is affected by the forces within and outside him or her. One of the roles of literature is to toy with this question of humanism, to describe its condition and how individuals strive to realize and exercise their humanity. This paper examines humanism and the urban environment as depicted in the selected novels of Kenya’s popular novelist, Meja Mwangi. To this end, Meja Mwangi’s popular fiction, Kill Me Quick (1973), Going Down River Road (1976) and The Cockroach Dance (1979) was critiqued in researching this question, given that literature reflects reality. The texts are Mwangi’s urban trilogy, among his forty-six novels. The study was qualitative in approach, employing analytical research design in the collection and analysis of data. The gathered data was analysed through content analysis. The study population comprised Kenyan popular fiction, with a special focus on novels by Meja Mwangi. The study further focused on Mwangi’s novels that are forty-six in number. Purposive sampling technique was employed with the inclusion criterion being Mwangi’s novels that address the humanistic issues being investigated. The sampled texts were Mwangi’s three urban-based novels mentioned above. The data was collected through close textual reading. Data collected was categorised along with the study’s units of analysis, namely Mwangi’s thematic concerns on humanism, characterisation, and narrative techniques. From the findings, a close reading of Kill Me Quick, Going Down River Road and The Cockroach Dance unravel instances and encounters with characters entangled in twists of fate in an urban locale. This is revealed through their actions, utterances and behaviour. It is also evident that the trilogy, particularly Kill Me Quick chronicles both rural and urban environments, whereas the other two centre on an urban locale. However, many issues have been raised in these novels about the urban space with its dislocation of individuals’ humane dispositions as their moral and cultural values gradually wane.
Análise sobre os espaços lúdicos e brinquedotecas presentes em centros municipais de educação infantil brasileiros
Authors: Bianchini Luciane Guimarães Batistella , Ferreira Ronielison Barbosa , Santos Andressa dos
Published: April 2022

A atividade lúdica na educação infantil é relevante, uma vez que se trata de uma das linguagens que a criança utiliza para construir a realidade. Nesse contexto, surgem as brinquedotecas escolares, oferecendo possibilidades variadas de brinquedos e brincadeiras que podem promover enriquecimento das ações lúdicas e se articulam à proposta político-pedagógica da escola e às práticas do professor. O objetivo consistiu em analisar as brinquedotecas presentes em Centros Municipais de Educação Infantil (CMEIs) brasileiros. Participaram da pesquisa 246 acadêmicos do curso de Pedagogia EaD de diferentes regiões do país. Os participantes dirigiram-se a um (ou mais) CMEI de sua respectiva cidade e, a partir da observação realizada naquele contexto, responderam a dois questionários disponibilizados na forma on-line. A análise dos dados foi organizada em dois eixos: a) caracterização dos CMEIs; e b) espaços lúdicos, brinquedotecas e prática pedagógica nos CMEIs. Os resultados indicaram que muitos CMEIs têm brinquedotecas ou espaços lúdicos, no entanto são utilizados, em sua maioria, para cobrir lacunas da rotina escolar, o que possibilita reflexões sobre a formação docente na Educação Infantil.
Metodologias ativas aplicadas em dois cursos técnicos pelos docentes no IFTO, Câmpus Palmas
Authors: Machado Luciane de Paula , Silva Antonelli Santos , Costa Ricardo Franco da , Faria Igor Guterres
Published: April 2022

O presente trabalho demonstra uma pesquisa desenvolvida em conjunto com professores do Instituto Federal de Educação, Ciência e Tecnologia Tocantins (IFTO), campus Palmas, nos cursos de formação técnica profissional de controle ambiental e segurança do trabalho, com o objetivo de determinar se os professores utilizam as metodologias ativas. Com métodos qualitativos, objetivos exploratórios e procedimentos de pesquisa bibliográfica, a coleta de dados foi realizada por meio de entrevistas com quatro docentes de dois cursos técnicos e entrevistas com questões abertas e fechadas. Segundo as constatações, todos os professores consideram que as metodologias ativas de aprendizagem são “bons” estimuladores da autonomia dos alunos e, embora tenham dificuldades em motivá-los e sensibilizá-los, utilizam vários métodos ativos de aprendizagem em sala de aula. As contribuições das teorias apresentadas nas aulas de formação profissional, que se podem observar durante as entrevistas realizadas com os professores, descreveram que estes não têm formação, mas possuem experiência na aplicação de metodologias ativas.
Relação família-escola no Brasil: um estado do conhecimento (1997-2011)
Authors: Nogueira Maria Alice , De Freitas Resende Tânia
Published: April 2022

Este artigo apresenta resultados de um estado do conhecimento que focalizou dissertações e teses sobre a relação família-escola cadastradas no banco da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) defendidas entre os anos 1997 e 2011. Foram identificados 266 trabalhos, dos quais se analisaram: o tipo (dissertação ou tese), o número de trabalhos no período e a distribuição por áreas de conhecimento. Os trabalhos da área de Sociologia da Educação (n = 88) mereceram um tratamento específico, identificando-se: tema, referenciais teóricos, procedimentos metodológicos, campo empírico e resultados. Traçou-se, assim, um panorama da produção sociológica brasileira sobre a relação família-escola no período, identificando-se suas principais tendências e lacunas, resultados convergentes e divergentes. Verificou-se uma produção crescente, com predomínio das abordagens qualitativas, do foco no ensino fundamental, na escola pública e nas famílias de meios populares, além de forte influência da literatura francesa. Parece necessário maior distanciamento crítico dos estudos em relação aos seus referenciais teóricos.
Percepções de uma equipe escolar sobre a educação em direitos humanos e mediação de conflitos
Authors: Silva Jennifer Catarine da , Nascente Renata Maria Moschen
Published: April 2022

O objetivo deste artigo foi analisar as percepções de professores(as) e da diretora de uma escola pública de ensinos fundamental e médio da rede estadual paulista para compreender como era concebida e vivenciada a Educação em Direitos Humanos (EDH) na escola e se seus princípios faziam parte dos processos de mediação de conflitos. A questão problematizadora foi: quais os conhecimentos daquela equipe escolar sobre a EDH e como eles se refletiam, ou não, em seu cotidiano, especialmente em processos de mediação de conflitos? A análise fundamentou-se na premissa de que os direitos humanos (DH) são a base da democracia participativa. Tratou-se de pesquisa qualitativa realizada por meio de análise documental, tendo sido investigados documentos oficiais que regulamentavam o trabalho sobre e com os DHs em escolas de educação básica. Além disso, foram realizadas entrevistas semiestruturadas com os seguintes membros da equipe escolar: diretora, professor coordenador, professora mediadora escolar e comunitária (PMEC) e professores(as). Os resultados indicaram a relevância da adesão das equipes escolares à EDH de maneira participativa e autônoma, envolvendo todos os segmentos, e, portanto, nesse processo, ensinando, aprendendo e vivenciando a justiça social e a democracia.
A luta pelo não fechamento da escola no campo: reflexões sobre a relação entre identidade territorial e mobilização política a partir da Comunidade São Tomé, Ilha do Marajó
Authors: Vieira Rodrigo Moreira , Soares Filho Gracinaldo da Silva , Costa Carla dos Santos , Corrêa Marcelo Rangel
Published: April 2022

Este trabalho tem como objeto o processo de mobilização social pelo não fechamento da Escola Municipal de Ensino Fundamental e Infantil São Tomé, localizada na comunidade de mesmo nome, em detrimento de processos de nucleação escolar ocorridos na estrutura de ensino no meio rural do Pará. De acordo com pesquisa levantada por alunos da graduação em Educação do Campo do Instituto Federal de Educação, Ciência e Tecnologia do Pará, campus Breves, como será observado, é possível afirmar que houve uma importância fundamental da identidade territorial no processo de mobilização de resistência pela manutenção da escola mencionada, o que, por seu turno, reforçou ainda mais a identidade territorial dos comunitários.
Mrs. Simpson Legacy Series: Dancing With Mrs. Simpson
Authors: Depass Cecille , Desnoes Denise , Cumper Pat , Burke Sydney
Published: April 2022

Preliminary sections of a tribute to the legacy of Mrs. Fay Simpson with memories  of her school on Hope Road in Kingston, Jamaica.
Telling/Dancing Our Stories Ourselves: Stories of the 1950s
Authors: DePass Cecille
Published: April 2022

Chapter 2 provides a kaleidoscope of memories from early ballet performances by students from Mrs. Simpson’s school.
Telling/Dancing Our Stories Ourselves: Denise's Story
Authors: DePass Cecille , Desnoes Denise
Published: April 2022

Chapter 3: Transitions 1 introduces dancer Denise Desoes and her magical trunk filled with costumes that she has danced in over many years, starting with those worn in the early Santa Clause Parades.

Chapter 4: Born to Dance has Denise telling her stories as a senior dancer at the Fay Simpson School of Dance in a series of flashbacks beginning with memories of the ballet Giselle.
Telling/Dancing Our Stories Ourselves: Stories of the 1960s
Authors: DePass Cecille
Published: April 2022

Chapter 5: Transitions 2: Introduction to Simpson ballet performances of the 1960s which demonstrated Faye Simpson's increasing       knowledge of dance and choreography.
Chapter 6: The White Witch Ballet: An overview of the creation and presentation of The White Witch of Rosse Hall ballet including historical background and its importance to Jamaican culture.
Chapter 7: The Three Mary's Ballet: Cecille's' memories of the Three Marys' Ballet which envisioned events that took place after Jesus' resurrection.
Dancing Our Stories Ourselves: Dancing with Mr. Neville Black
Authors: DePass Cecille
Published: April 2022

Chapter 10: Introduction to Jazz and Modern Dance, Take 5: Cecille recounts her experiences dancing with Neville Black, a modern dancer who was trained in the USA and returned to Jamaica to choreograph and teach modern and jazz dance to teens and adults. He choreographed several dances for Mrs. Simpson’s ballet performances, and taught with her in the 1960s.
Endings and New Beginnings
Authors: DePass Cecille , Desnoes Denise , Mowatt Michele
Published: April 2022

Chapter 11: Transitions 4: The Grand Finale involving the entire cast brings the book to a close with a fictitious dance performance entitled "Tributes".
Chapter 12: Tributes:
                 Denise's Concluding Thoughts: The Memories Linger and Last
                 Epilogue by Michellle Mowatte
Bezpośrednie formy partycypacji pracowniczej. Polska na tle starych krajów Unii Europejskiej
Authors: Rudolf Stanisław , Skorupińska Katarzyna
Published: April 2022

Rosnącą popularność bezpośrednich form partycypacji pracowniczej wiązać należy z szybkim rozwojem nauk o zarządzaniu. Narastająca konkurencja zmuszała pracodawców do poszukiwania nowych źródeł przewagi konkurencyjnej przedsiębiorstwa, wśród których dostrzeżono niewykorzystany dotychczas olbrzymi potencjał intelektualny pracowników. Wykorzystywanie tego potencjału zaowocowało wzrostem pracowniczego zaangażowania w problemy przedsiębiorstwa, przedsiębiorczości i kreatywności, identyfikowania się z interesami przedsiębiorstwa. Przyniosło to poprawę rezultatów ekonomicznych przedsiębiorstwa. Jedyną drogą, prowadzącą do tego celu jest partycypacja pracownicza, w tym przede wszystkim partycypacja bezpośrednia, nazywana również demokracją warsztatową. Oznacza ona bezpośredni udział zarówno indywidualnych pracowników jak i zespołów pracowniczych w podejmowaniu decyzji w ich miejscu pracy. Formy te spotkały się z poparciem pracowników, przynoszą bowiem zaspokajanie ich coraz wyższych potrzeb, takich jak: potrzeba zadowolenia i satysfakcji z wykonywanej pracy, potrzeba wykorzystywania posiadanych kwalifikacji, potrzeba samorealizacji itp. Sprawiło to, że w wielu krajach zyskały one dużą popularność i ich zakres nadal rośnie. Książka prezentuje różnorodność form takiej partycypacji, a także jej wpływ na rezultaty ekonomiczne przedsiębiorstwa. Zakres tych form w warunkach polskich, a także ich rezultaty zostały przedstawione na tle dziesięciu starych krajów Unii Europejskiej.
Reducción de la complejidad en procesos con Six Sigma: Un caso de estudio en la industria electrónica
Authors: Martínez-González Karla Guadalupe , Armendáriz-Mireles Eddie Nahúm , Rodríguez-García José Amparo , Calles-Arriaga Carlos Adrián , Rocha Rangel Enrique
Published: April 2022

La complejidad es inherente a cualquier proceso. Por ello, las consecuencias de malas administraciones empíricas son un aumento de los riesgos, la incertidumbre y los costos innecesarios. Sin embargo, existen diferentes herramientas destinadas a medir y reducir la complejidad de los sistemas productivos. El valor de Six Sigma se deriva de la estandarización para la solución de problemas y de la orientación sobre las herramientas aplicables a un proyecto para reducir la complejidad.  Cómo guiar a las personas a sugerir qué herramientas aplicar y en qué orden para un proyecto o problema y que al mismo tiempo reduce la complejidad.  Esta investigación propone la enseñanza e implementación de las herramientas clave de la metodología Six Sigma para profesionales no expertos de Six Sigma para reducir la complejidad de los sistemas y procesos en sus ambientes laborales. Además, este trabajo comparte los principios implementados con éxito en todo el mundo utilizando Six Sigma. Finalmente, este estudio demuestra la implementación de la metodología DMAIC a través de un caso de práctico en la industria electrónica.
Estrategia de comunicación científica en la Web 2.0 para la universidad contemporánea: divulgación y visibilidad de la comunicación científica y académica
Authors: Mayorga-Albán Amalín , Pacheco-Mendoza Silvia , Córdova-Morán Jorge , Samaniego-Villarroel Jonathan
Published: April 2022

La actual sociedad de la información y del conocimiento, nos conlleva a ejecutar diversas estrategias para la difusión científica y académica en las universidades, es así como el uso cotidiano de la web 2.0 y  la búsqueda de información han revolucionado los procesos de divulgación científica. En los últimos tiempos han emergido nuevas tendencias de modelos de comunicación multiformato a través de las Web 2.0, en los que se llegan a presentar contenidos de diversos tipos, partiendo desde netamente informativos hasta exposición de informes y resultados de investigaciones. El objetivo del presente estudio corresponde a analizar las diversas estrategias de comunicación científica que se ejecutan en la web 2.0, para lo cual se ha realizado un estudio cuantitativo y se desarrolla el análisis estadístico de los resultados obtenidos; los métodos de investigación aplicados corresponden al método empírico de la observación y a los métodos teóricos analítico sintético e inductivo deductivo.
Where Physics Meets Biology
Authors: Nicodemi Mario
Published: April 2022

The frontier between life and physical sciences currently includes the strategic research field where the wealth of data produced by new quantitative technologies in molecular biology naturally meets the advanced analysis and modelling tools of theoretical physics. For its profound scientific implications and huge potential impacts in biomedicine, such an area of investigation is attracting substantial interest. Therefore, in the following contribution, I briefly review some developments in the research field under scrutiny.
Variation of soil attributes along a sandstone-gneiss toposequence in southern Amazonas, Brazil
Authors: Brito Filho Elilson Gomes de , Campos Milton César Costa , Silva Laércio Santos , Silva Julimar Fonseca da , Silva Guilherme Abadia da , Cunha José Maurício da , Lima Alan Ferreira Leite de
Published: April 2022

Soil-landscape relationships in natural environments can provide helpful insights into soil suitability and limitations and necessary changes regarding agricultural land use and management. The objective of this work was to verify soil variations along a sandstone-gneiss lithological toposequence in the western Amazonian region of Brazil. Within this topolithosequence, the following soil profiles were sampled: CAMBISSOLO HÁPLICO (Dystric Leptic Cambisol), NEOSSOLO REGOLÍTICO (Cambic, Lithic, Leptosol), NEOSSOLO QUARTZARÊNICO (Dystric Regosol), PLINTOSSOLO PÉTRICO (Petric, Plinthosol), and ARGISSOLO AMARELO (Chromic, Abruptic, Acrisol). These profiles were located on the following slope segments: interfluve (P1), convex creep slope (P2), transportational midslope (P3), colluvial footslope (P4), and alluvial toeslope (P5). Soil analyses included physical and chemical attributes. The influence of the landscape on soil attributes was evaluated through randomness test, run charts, Pearson correlation, and Tukey test at a 5% significance level. Soil chemical properties were more sensitive to slope-related variations, with increased chemical quality in P2 for both horizons. Soil organic matter proved to be crucial for improving the chemical and physical quality of sandstone soils.
Ultrasonic System to Automatically Measure Size of Cracks using the Snooker Algorithm, a Simulator and Machine Learning
Authors: Nageswaran Channa
Published: April 2022

Cracking in a wide array of industrial components and structures pose a significant threat to their integrity. Detecting cracks using ultrasonic inspection techniques is a widespread activity for economic reasons but there are limitations to the techniques due to the morphology of cracks, such as fatigue cracks. In addition to detection there is a need to measure the size of the cracks which are often within the volume of the material. Ultrasonic techniques are well-suited to look inside the volume of the material but achieving sufficient sensitivity to the tip of the cracks in particular is practically difficult. Without an accurate knowledge of where the tip of the crack lies there can be significant uncertainty in sizing measurements. Machine Learning (ML) techniques are being developed to aid in the inspection and monitoring tasks but presenting the ultrasonic data in a suitable way for ML is very important. Following on from recent work presenting the development of the snooker algorithm to create images termed parameter-spaces, this paper presents how these images can be input into neural network based ML systems to automatically size these critical cracks.
Ultrafast Carrier Dynamics in Two Dimensional NbTe2 Films
Authors: Moss David
Published: April 2022

As one of the representatives of emerging metallic transition metal dichalcogenides, niobium ditelluride (NbTe2) has attracted intensive interest recently due to its distorted lattice structure and unique physical properties. Here, we report on the ultrafast carrier dynamics in NbTe2 measured using time-resolved pump-probe transient reflection spectroscopy. A thickness-dependent carrier relaxation time is observed, exhibiting a clear increase in the fast and slow carrier decay rates for thin NbTe2 flakes. In addition, pump power dependent measurements indicate that the carrier relaxation rates are power-independent, with the peak amplitude of the transient reflectivity increasing linearly with pump power. Isotropic relaxation dynamics in NbTe2 is also verified by performing polarization-resolved pump-probe measurements. These results provide an insight into the light-matter interactions and charge carrier dynamics in NbTe2 and will pave the way for its applications to photonic and optoelectronic devices.
The Role of Extraordinary Chambers in the Courts of Cambodia in trying Khmer Rouge Human Rights Offender in Cambodia
Authors: Haq Ahza Arzanul , Krisanti Dea Putri , Wiguna Zein Ibnu
Published: April 2022

Conflict often occurs when two or more interests are in contradiction and no one wants to concede. We know a variety of conflicts today, from the conflict preexisting since a long time ago such as intertribal conflict to more modern conflict such as a state’s tapping over another. The way of resolving conflict is also varying according to the types of conflict, big conflict such as interstate conflict or the one attracting the world’s attention, using more complex resolution and usually using the third party. Therefore, a special organization will be founded to solve a conflict. One of organizations created to solve a conflict is the Extraordinary Chambers in The Courts of Cambodia (ECCC) aiming to try the war criminals during Khmer Rouge humanity crime incidence in 1975-1979. Humanity crime occurring in Cambodia is one of largest humanity tragedies in modern era post 2nd World War. This ECCC was founded because at that time Cambodia’s National Justice Institution could not try the perpetrator of humanity crime. Cambodian government along with UN then agreed to found a justice institution specifically aiming to deal with and to resolve Khmer Rouge case.
Thailand Government Strategy and Policy in Handling The COVID-19 Pandemic
Authors: Tunggal Hamas Nurhan Rabbani , Putra Madda Asyafa , Salim Mario Ben
Published: April 2022

The Covid-19 pandemic destroyed various countries from various aspects. One of the countries affected is Thailand. For Thailand itself, they are more disadvantaged in the economic sector. Given that one of the leading economic suppliers in Thailand is from the tourism sector. The sector has also been devastated due to the absence of foreign tourists visiting Thailand due to the pandemic. With this, the local Government has taken various ways to restore the situation to normal. Four things are under the Government's spotlight, including the health insurance system, the application of social distancing, the imposition of national emergency status, and economic stimulus. With these several things, it can be said that this journal will discuss how the Thai government policy in fighting Covid-19 from the health sector, the economy, and others. In his efforts, many polemics occurred due to quite controversial policies. One example is when the Government asked rich people in Thailand to help solve the problem. It brought a lot of negative response on social media, for example, is much-scattered hashtag #BeggarGovernment.
China's COVID-19 Vaccine Diplomacy as China's Effort in Increasing Its Influence in the ASEAN Region
Authors: Sari Venisa Yunita
Published: April 2022

The coronavirus outbreak (now known as COVID-19) is rapidly spreading throughout the world, and Southeast Asia is no exception. COVID-19 has affected many aspects of human life. The threat of this global pandemic is transnational, so regional and multilateral cooperation is needed. Therefore, it is necessary to find a vaccine to defeat the pandemic. Developed countries began to race to find vaccines and put the first access to vaccines for the benefit of their countries. In this case, China is a country that offers cooperation in providing massive vaccines to developing countries, including ASEAN member countries through its vaccine diplomacy scheme. This offer of cooperation cannot be separated from China's own interests. This research uses a qualitative case study method with analytical descriptive. This study uses an approach to China's interests and geopolitics in the Southeast Asia region. This article intends to explore and elaborate on China's efforts to increase its influence in the ASEAN region as a form of its geopolitical strategy in the form of vaccine diplomacy. The results of the research in this article are that China seeks to improve its image and achieve geopolitical interests in ASEAN by taking advantage of opportunities from the distribution of Sinovac and Sinopharm vaccines.
Jornadas de Papirología, ‘versión pandémica’ (9.5, 9.6 y 9.7)
Authors: Jiménez Leia
Published: April 2022

16-17 Julio 2020; 21-22 septiembre 2020; 19 febrero 2021.
Expression of Sortilin in Pancreatic Carcinoma and Influence of Pancreatic Cancer Cells by Sortilin siRNA Knockdown
Authors: Xu Di , Yu Fang , Liu shangqing , Cai Rong
Published: April 2022

Background: Currently, there are few effective therapeutic options for pancreatic cancer patients.Sortilin is a member of vps10p receptor family，reported in many types of cancers.However, the underlying mechanism and prognostic value of sortilin in pancreatic cancer are still unclear. Objective:Understand the expression of sortilin in pancreatic cancer, and analyze its mechanism that affects the occurrence and development of pancreatic cancer. Methods:A tissue microarray of 115 pancreatic cancer metastases was analyzed by immunohistochemistry. All data were analyzed by univariate analysis and multivariate analysis.Multivariate logistic regression analysis and the area under the receiver operating characteristic (ROC) curve were used to analyze the ability of sortilin in predicting pancreatic cancer.Next, survival analysis was performed to compare the survival time between high-risk and low-risk patients to validate the prognosis prediction efficacy of sortilin.The effects of sortilin on the invasion，metastasis and proliferation of pancreatic cancer cells were investigated both in vitro. investigate the anti-cancer effect of soritlin on human pancreatic cancer Capna1 and Bxpc3 cells, and its possible molecular mechanism.Results:Differential expression analysis of 115 tissue microarrays showedsortilin expression was up‐regulated in pancreatic cancer tissues,and it mainly comes from the nucleus. Sortilin expression in nucleus(SEIN) was only negatively correlated with N stage, Binary logistic regression model showed that SEIN is a good diagnostic marker for predicting pancreatic cancer and the accuracy of prediction is as high as 79.1 %. ROC curve analysis demonstrated a statistically significant diagnostic value of SEIN,and the diagnostic accuracy was 86.3%, The Youden Index was calculated to evaluate the diagnostic power, The cut-off value for SEIN in pancreatic cancer diagnosis was 0.85, with a sensitivity of 90.9% and a specificity of 68.3%. Univariate analysis showed that M stage(P=0.022), histological grade(P=0.021), clinic stage(P=0.030)and SEIN(P=0.039) were correlated with prognosis of pancreatic cancer patients, Multivariate regression analysis showed that M stage(P=0.036)and ESIN(P=0.004) were independent factors.The proliferation, invasion and migration of pancreatic cancer cells were inhibited in vitro by sortilin siRNA knockdown.it may have something to do with soritlin/P53/NFκB regulated the the proliferation function and sortilin/MMP9 regulated the invasion-promotion of pancreatic cancer cells. Conclusions: These fndings demonstrated that the low expression of SEIN indicates better prognosis in pancreatic cancer and supplemented the effect mechanism of sortilin on pancreatic cancer cells. SEIN expression may serve as a potential diagnostic indicator of pancreatic cancer.
Implementing SMS reminders for routine immunization in Northern Nigeria: a qualitative evaluation using the RE-AIM framework
Authors: Obi-Jeff Chisom , Garcia Cristina , Adewumi Funmi , Bamiduro Tobi , David Winnie , Labrique Alain , Wonodi Chizoba
Published: April 2022

Background: SMS reminders have improved vaccine uptake in clinical and community settings in low- and middle-income countries (LMICs). However, the limited use of SMS reminders in LMICs requires evaluating the intervention’s internal and external validity to improve adoption and sustainability. Using the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework, we qualitatively assessed the impact of an SMS reminder intervention implemented in Kebbi State, Northwest Nigeria, between May 20, 2019, and May 31, 2020. This is to guide and inform future SMS reminder interventions to improve childhood immunization uptake in LMICs. Methods: In June 2020, we conducted 14 focus group discussions, 13 in-depth interviews, and 20 key informant interviews among 144 purposively selected participants from five local government areas of Kebbi State. For analysis, we used a deductive approach to develop preliminary codes based on the RE-AIM framework and the inductive approach to generate themes that emerged from the interviews. Results: The perceived importance and impact of the SMS reminder in improving demand and uptake for vaccination were the consistent contributing factors that encouraged participants’ participation. Other facilitators included the involvement of health workers in supporting SMS reminder registration and community gatekeepers using existing structures to convey messages on scheduled immunization services. Policymakers adopted the intervention because it aligns with the State’s priority to improve immunization coverage. Similarly, the SMS reminder appealed to health workers and program managers because it reduced their workload and served as a performance monitoring tool to track immunization and intervention defaulters. Despite these, low mobile phone ownership and the inability to read text messages due to the low literacy level were the main barriers during implementation. Finally, data availability on cost-effectiveness and the intervention’s impact to improve coverage was critical for scalability. Conclusions: Our study demonstrated that SMS reminders in local languages could improve vaccination demand and uptake in resource-constrained settings due to its perceived importance and impact. Addressing the cited implementation barriers and promoting the facilitators is critical to its adoption and sustainability. Costing and impact data are needed to collaborate findings on the effectiveness of the SMS reminder to improve childhood vaccination uptake.
Pentixafor as a theranostic agent in rectal and pancreatic adenocarcinoma: outcomes from a pilot study
Authors: Ahern Elizabeth , Thomas Paul , Campbell Louise , Latter Melissa , Eastgate Melissa , Wyld David , Clark David A , Stevenson Andrew R.L , O’Rourke Nicholas , Cavallucci David , Bryant Richard , Burge Matthew
Published: April 2022

Background: Accurate staging is essential in the management of pancreatic and rectal adenocarcinomas, and where prognosis after management of advanced, unresectable disease remains poor, further treatment options are urgently needed. CXCR4 is the receptor for chemokine CXCL12, with enriched expression in malignant compared with normal tissue, and putative tumorigenic signalling functions. Pentixafor, a peptide targeting CXCR4, is a theranostic agent capable of being labelled with gallium-68 (Ga-68) for positron emission tomography (PET) imaging, and lutetium-177 (Lu-177) for therapy. Using PET scanning, we sought to explore the potential utility of pentixafor as a theranostic agent by examining avidity of Ga-68-pentixafor uptake in a pilot study of patients diagnosed with rectal or pancreatic ductal adenocarcinoma (PDAC).Methods: We performed a single-arm, prospective, single-institution pilot study. Patients with newly diagnosed pancreatic or rectal adenocarcinoma received Ga-68-pentixafor-PET in addition to the usual clinical and radiologic workup for their disease. Suitability for peptide receptor radionucleotide therapy (PRRT) was judged using the Thera-P trial criteria[1]. Using binomial probability, a target of 12 patients was set for recruitment for each cancer cohort, given that if more than seven patients demonstrated insufficient uptake, there would be 95% confidence that a sensitivity threshold which would be deemed to warrant further investigation in a larger study (85%) would not be met.Results: Pentixafor-PET was administered to 8 rectal cancer patients and 9 PDAC patients and no adverse events were noted. Low-to-moderate levels of pentixafor tracer avidity was demonstrated at all sites of primary disease, most sites of nodal metastatic disease and some distant metastases in each cohort, although less uptake relative to Fluorodeoxyglucose (FDG)-PET/CT was noted suggesting that use of pentixafor is inferior to FDG in staging. No patients satisfied PRRT suitability criteria and further recruitment was terminated.Conclusion: In this small pilot study, insufficient pentixafor avidity was demonstrated in cases of rectal cancer and PDAC to warrant further exploration as a potential candidate for radionuclide therapy.Trial registration: Australian New Zealand Clinical Trials Registry. ACTRN12617000596303 (rectal). ACTRN12617000595314 (pancreatic). Registered on 27th April 2017. https://www.anzctr.org.au/TrialSearch.aspx.First patient was enrolled on 2nd May 2017
Gastric metastasis of hpeatic sarcomatoid carcinoma: a case report and literature review
Authors: Ma ShuoShuo , Zhang DengYong , Zhao GuanRu , Ding Sheng , Wu Qiong , Zhang XueLi , Lu Zheng
Published: April 2022

Background
Hepatic sarcomatoid carcinoma (HSC), an extremely rare malignant tumor in clinical practice, mostly occurs in the right lobe and rarely in the left lobe of the liver. This paper reports a case of sarcomatoid carcinoma that occurred in the left outer lobe of the liver, accompanied by gastric stromal tumors (GSTs) of the greater curvature of the stomach, and the patient developed gastric metastasis of liver sarcomatoid carcinoma in the later stage.
Case presentation:
A 63-year-old male patient was diagnosed with both HSC and GST. With fever as the main clinical manifestation, the liver malignant tumor was detected after he underwent abdominal computer tomography (CT) and ultrasound-guided percutaneous liver biopsy at the local hospital. The patient came to our hospital for further treatment. During the next electronic gastroscopy, we found multiple submucosal tumors (SMT) in the stomach. Without multiple metastases in other parts, we performed left hepatic lobe resection with gastric partial resection, and the postoperative pathology determined the presence of HSC and GST. One month after surgery, the patient felt well, and the imaging examination found no obvious space-occupying lesions in other areas. Unfortunately, four months later, the patient showed pain in the upper left abdomen and found metastases in the stomach. We performed the operation on him again, and the patient recovered well after the operation. The patient was still alive at the time of writing this paper.
Conclusion
Hepatic sarcomatoid carcinoma lacks characteristic clinical manifestations and is highly malignant. Surgery is the first choice for the treatment of patients with HSC. For sarcomatoid cancer that occurs in the left lobe of the liver, we need to be highly vigilant against the tumor's invasion of the stomach tissue, especially when the tumor breaks through the capsule of the liver. In addition, during the operation, doctors need to perform delicate operations to avoid dissemination and metastasis of the gastrointestinal tract.
Effect of Human Platelet Lysate as Cultivation Nutrient Supplement on the Expansion of Human Natal Dental Pulp Stem Cells In Vitro
Authors: Pilbauerova Nela , Schmidt Jan , Kleplova Tereza Suchankova , Soukup Tomas , Suchanek Jakub
Published: April 2022

Background
Despite scientific and ethical issues, fetal bovine serum (FBS) remains the standard nutrient supplement in the mesenchymal stem cell cultivation medium. Given that cell amplification plays an important role in human stem cell therapies, there is an increasing interest in finding suitable human alternatives to FBS for in vitro cell propagation. One such alternative is human platelet lysate (hPL).
Methods
Our study aimed at evaluating the influence of 2% hPL in growth medium for in vitro expansion of human natal dental pulp stem cells (hNDP-SCs). We determined the effect this medium had on proliferation rate, viability, phenotype profile, expression of several markers, relative telomere length change, and differentiation potential of four lineages of hNDP-SCs. As a control, hNDP-SCs were simultaneously cultivated in 2% FBS.
Results
hNDP-SCs cultivated in hPL showed a statistically significantly higher proliferation rate in initial passages. We did not observe a statistically significant effect on mesenchymal stem cells marker (CD29, CD44, CD73, CD90) or stromal-associated marker (CD13, CD166) expression. The cell viability, relative telomere length, and multipotency remained unaffected in hNDP-SCs cultivated in hPL-medium.
Conclusions
In conclusion, hPL produced under controlled and standardized conditions has demonstrated to be an efficient serum supplement for in vitro expansion of hNDP-SCs.
Clinical and microbiological characteristics of and risk factors for bloodstream infections among patients with extracorporeal membrane oxygenation: A single-center retrospective cohort study
Authors: Lee Eun Hwa , Lee Ki Hyun , Lee Se Ju , Kim Jinnam , Baek Yae Jee , Ahn Jin Young , Jeong Su Jin , Ku Nam Su , Choi Jun Yong , Yeom Joon-Sup , Song Young Goo , Kim Jung Ho
Published: April 2022

Background Extracorporeal membrane oxygenation (ECMO) provides hemodynamic and oxygenation support to critically ill patients. Due to multiple catheter cannulations, patients on ECMO are vulnerable to bloodstream infections (BSIs). We aimed to investigate the incidence, clinical characteristics, risk factors, and microorganisms associated with BSIs during ECMO. MethodsThis single-center retrospective cohort study was conducted between January 2015 and May 2021. Patients aged 18 years or older with an ECMO duration of >48 hours for cardiogenic or respiratory support were included in the study. Patients who developed bacteremia or candidemia from 12 h after ECMO cannulation to 7 days after de-cannulation were included. The clinical factors between non-BSI and BSI were compared, along with an analysis of the risk factors associated with BSI during ECMO. Results A total of 480 patients underwent ECMO for cardiogenic shock (n=267, 55.6%) or respiratory failure (n=213, 44.4%) during the study period. The incidence was 20.0 episodes per 1,000 ECMO-days. Approximately 20.2% (97/480) and 5.4% (26/480) of the patients developed bacteremia and candidemia, respectively. The median numbers of days of BSI development were 8.00 days for bacteremia and 11.0 days for candidemia. The most common pathogens were methicillin-resistant coagulase-negative staphylococci (n=24), followed by vancomycin-resistant Enterococcus (n=21). Multivariable logistic analysis demonstrated that hemodialysis (odds ratio [OR]=2.647, p<0.001), veno-arterial-venous mode (OR=1.911, p=0.030), and total ECMO duration (OR=1.030, p=0.007) were significant risk factors for bacteremia. The total ECMO duration was the only risk factor associated with candidemia (OR=1.035, p=0.010). The mortality rate was significantly higher in the bacteremia (57.7 %) and candidemia (69.2 %) groups than that in the non-BSI group (43.6%). ConclusionBSI is a common complication of patients receiving ECMO support and is associated with poor clinical outcomes. Determining the type of frequently isolated organisms and the median onset time of BSI would help in the selection of appropriate prophylactic antibiotics or antifungal agents.
A new treatment option for stage IIIB lung squamous cell carcinoma-Hypofractionated brachytherapy combined with ICIs: A Case Report
Authors: WEI CHUN , Cui Ran , Li Yixian , Jiang Ou
Published: April 2022

Here, we present a case of a patient with stage IIIB squamous lung cancer with mediastinal and cervical lymph node metastases in the left lung with peripheral squamous lung cancer, who was selected for simultaneous immunotherapy with insertional radiotherapy at the primary site in the left lung, followed by intensity-modulated radiotherapy for mediastinal and cervical lymph node metastases and maintenance immunotherapy every 3 weeks. There was no treatment-related toxicity above grade 2 during the treatment. The response was PR, and PFS was more than 12 months. That provides a new therapeutic idea for treating advanced squamous lung cancer.
Increased level of Complement C3 in patients with osteoporosis and enhanced osteogenic ability in osteoblasts with Complement component 3 knockdown
Authors: Liu Kang , Yu Yang , Tong Minghao , Tang Binbin , Shi Xiaolin
Published: April 2022

Objective(s):Complement C3 has the potential to impact bone homeostasis. The purpose of this study is to determine the difference in serum Complement C3 levels between osteoporosis patients and non-osteoporosis patients, as well as how Complement C3 silencing impacts and works on osteoblast osteogenesis.Materials and Methods: 58 people who underwent dual energy X-ray bone mineral densit(BMD) measurement in The Second Affiliated Hospital of Zhejiang Chinese Medical University from June to September 2021 were analyzed retrospectively. According to the classification of BMD t value, the subjects were divided into 31 cases in osteoporosis group and 27 cases in non- osteoporosis group. Complement C3 levels were recorded. and compared between the two groups. Then, the Complement C3 knockdown lentivirus was used to transfect Raji. The Raji-osteoblast line MG63 co-culture system was constructed after the stable strain was screened. CCK-8 and flow cytometry were used to assess the proliferation and apoptosis of MG63, alkaline phosphatase (ALP) activity was used to evaluate the osteogenic ability of MG63, and RT-PCR was used to assess the expression level of osteoprotegerin（OPG）of MG63.Results:Complement C3 levels in osteoporosis patients' serum are elevated，the proliferation level and osteogenic ability of MG63 were improved in Complement C3 knockdown Raji-osteoblast MG63 co-culture system. Furthermore, OPG expression in MG63 was enhanced.Conclusion:To sum it up, the level of Complement C3 in the serum of osteoporosis patients is elevated.Knocking down Complement C3 boost osteoblast osteogenic ability, which may be achieved by controlling OPG / RANKL / RANK system.
Association of potassium concentration and variability with mortality among patients requiring continuous renal replacement therapy in intensive care units: a hospital-based retrospective cohort study
Authors: Kor Chew-Teng , Mao I-Chieh , Lin Pei-Ru , Wu Shin-Hwar , Hsu Hsin-Hui , Hung Pei-Shan
Published: April 2022

Background: Serum potassium between 3.5 to 5.0 mmol/L is known to be a safe range for patients. The optimal serum potassium level for critically-ill patients with acute kidney injury undergoing continuous renal replacement therapy (CRRT) remains uncertain. This retrospective analysis investigated the association between ICU mortality and potassium concentrations and variability. Methods: ICU patients aged 20 or older, with a minimum of two serum potassium values during received CRRT, treated in ICU in a tertiary hospital in central Taiwan between 1 January 2010 and 30 April 2021 were eligible for inclusion. Patients were categorized into groups of mean potassium: <3.0, 3.0 to <3.5, 3.5 to <4.0, 4.0 to <4.5, 4.5 to <5.0, and ³5.0 mmol/L; potassium variability was divided by quartiles of the average real variation. We analyzed the association between potassium concentration and variability with mortality and performed Cox’s proportional hazard models.Results: We studied 1991 CRRT patients with 9891 serum potassium values within 24 hours after receiving CRRT. There was a J-shaped association between serum potassium and mortality, with the lowest mortality observed in patients with mean potassium concentrations between 3.0 and 4.0 mmol/L. The risk of in-hospital death was also significantly increased in those with the highest variability [HR and 95% CI=1.31(1.03-1.65) for in-hospital mortality; 1.39(1.06-1.82) for 28-day mortality and 1.43(1.11-1.83) for 90-day mortality, respectively].Conclusions: Patients receiving CRRT may benefit from a lower and tighter serum potassium control. During CRRT, progressively increased mortality was noted in patients with higher potassium variability. Thus, careful and timely correction of dyskalemia among these patients is particularly important.
Prediction model of ischemic stroke based on machine learning
Authors: Zhang Zhijie , Zou Zhihong , Yang Junjie , Guan Xin , Chen Xialan
Published: April 2022

Background Existing research focuses on the identification of key risk factors for stroke, improves the accuracy of stroke risk prediction, and provides more evidence for the scientific diagnosis, treatment and intervention of stroke. Methods We included 4785 cases, stratified by sex (men: n=3156; women: n=1629) and age (18-40 years; 41-54 years; 55-69 years; 70+ years), the survey data of stroke patients conducted by Cooperative Hospital from 2019 to 2020. After data preprocessing, an extreme learning machine was used to construct a stroke risk prediction model.Results The stroke risk prediction model was identified that total cholesterol and high-density lipoprotein were the 10 most important risk factors affecting the onset of stroke. The prediction accuracy rate of the risk prediction model is 97%.Conclusion The method in this paper can quickly and effectively dig out the key risk factors affecting the onset of stroke from the data, and predict the risk of the onset, which has high application value.