bluuebunny/crossref_metadata_2025 huggingface dataset:
Potential role of the mTOR-C1-PGC1α-PPARα axis under type-II diabetes and hypertension in the human heart
Authors: Hang Tianyu , Lumpuy-Castillo Jairo , Goikoetxea-Usandizaga Naroa , Azkargorta Mikel , Aldámiz Gonzalo , Martínez-Milla Juan , Forteza Alberto , Cortina JMaría , Egido Jesús , Elortza Félix , Martínez-Chantar Malu , Tuñón José , Lorenzo Óscar
Published: February 2023

Background: Type-2 diabetes (T2DM) and arterial hypertension (HTN) are major risk factors for heart failure. Importantly, these pathologies could induce synergetic alterations in the heart, and the discovery of key molecular signaling may suggest new targets for therapy.
Methods and Results:: Intraoperative cardiac biopsies were obtained from patients with or without HTN and/or T2DM. Control (n=5), HTN (n=7) and HTN+T2DM (n=7) samples were analyzed by proteomics and bioinformatics. Cultured cardiomyocytes were used for further in vitro studies.
In cardiac biopsies from patients with cardiopathy but preserved systolic function we found significant alterations of 677 proteins. After filtered out non-cardiac factors, 529 and 41 were changed in HTN-T2DM and in HTN subjects, respectively, against control. Interestingly, 81% of proteins in HTN-T2DM were distinct from HTN, while 95% from HTN were common with HTN-T2DM. In addition, 78 factors were differentially expressed in HTN-T2DM against HTN, predominantly downregulated proteins of mitochondrial respiration and lipid oxidation. Bioinformatic analyses suggested implication of mTOR signaling and reduction of AMPK and PPARα activation, and regulation of PGC1α, fatty acid oxidation, and oxidative phosphorylation. In cultured cardiomyocytes, an excess of palmitate activated mTOR-C1 complex and subsequent attenuation of PGC1α-PPARα transcription of b-oxidation and mitochondrial electron chain factors, affecting the mitochondrial/glycolytic ATP synthesis.
Conclusions: The coexistence of HTN and T2DM induced higher alterations in cardiac proteins than HTN. HTN-T2DM subjects exhibited a dramatic downregulation of mitochondrial respiration and lipid metabolism. The mTOR-C1-PGC1α-PPARα axis might account as a target for future therapies.
PP2 alleviates the progression of osteoarthritis by inhibiting Wnt/β-catenin and activating TGF- β/Smad signaling
Authors: Zhang Hao , Li Kai , Chen Wei , Li Xiaoqiang , Wang Jinshu , Wang Taikun , Zhao Qi , Huang Hao , Li Yiting , Tang Yujin , Pan Shengcai , Liu Jia , Wang Liqiang
Published: February 2023

Objective
Explore the effect and mechanism of Src inhibitor PP2 on knee osteoarthritis.
Methods
The protein expressions of Src, p-Src (y418) and p-FAK in normal and OA human chondrocytes were detected by immunofluorescence (IF). Chondrocytes from the femur and tibial plateau of 3-day-old mice were extracted and inoculated into 6-well plates. The chondrocytes were co-cultured with IL-1β and different doses of PP2, and then the degeneration of chondrocytes was observed. The OA model was induced by destabilizing medial meniscectomy in the right knee of mice; two weeks after the operation, different doses of PP2 were injected intraperitoneally. The medicine was given 3 times a week for 6 weeks, and then we took the knee cartilage of each group, and the degree of degeneration was observed.
Results
The levels of Src, p-Src (y418) and p-FAK in knee cartilage tissue of patients with OA were abnormally increased. After chondrocytes were co-treated with IL-1β and different doses of PP2, the results showed that PP2 could reduce the abnormal increase of β-catenin, p-β-catenin and other proteins created by IL-1β and reverse the decrease of p-Smad3, Aggrecan and collagen Ⅱ proteins. Meanwhile, intraperitoneal injection of PP2 in vivo significantly reduced the degeneration of articular cartilage.
Conclusion
Our data show that PP2 can inhibit Wnt/β-catenin and activate TGF-β/Smad signaling, thus protecting the cartilage of OA mice.
The Impact of Meteorological Parameters on the Number of Applications to the Emergency Department with Urticaria: A Retrospective Study
Authors: Delice Orhan , Güçlü Sibel Utlu , Arslan Şenol , Doru Halil İbrahim , Daş Murat
Published: February 2023

Objective
The study aimed to investigate the relationship between the patients who applied to the emergency department with acute urticarial and meteorological factors and determine the associated weather conditions.
Methods
The relationship between acute urticaria patients who applied to the emergency department of a training and research hospital in a city with high altitude and continental climate characteristics in the eastern part of Turkey between January 2019 and December 2019, with meteorological data was evaluated retrospectively. The necessary data for the weather were obtained from the data of the Erzurum Meteorology Directorate, and the patient data were obtained from the hospital information management system and patient files. The meteorological data of the patients at the date of admission and the characteristics of the patients at that date were compared.
Results
The study identified 691 patients who applied to the emergency department diagnosed with urticaria in 2019. According to the seasons, it was observed that the patients applied most frequently in the summer months [(n = 239 (34.6%)]. In the univariable regression model, which was created by taking the values of weather events as a reference on the days when the urticaria presentation was not observed (Group I), it was determined that every 1-hour increase in the sunshine hour increased the probability of urticaria by 7.4% (p = 0.018). When the meteorological parameters on the days without urticaria (Group I) and the days with urticaria presentation (Group II) were compared, the sunshine hours were 7.9 (4.0-10.6) hours in Group II and 6.65 (3.3–8.85) hours in Group I (p = 0.001). Regarding relative humidity, higher humidity rates were observed in Group I compared to Group II (p = 0.009). In terms of mean temperature, daily maximum, and minimum temperature, higher temperature rates were detected in Group II (p < 0.001).
Conclusion
A relationship was determined between urticaria attacks and relative humidity and daily maximum and minimum temperature in patients who applied to the emergency department with acute urticaria.
‹Uns geht es ja noch gut. Wir haben ja ein grosses Haus mit einem Garten›
Authors: Neto Carvalho Isabel , Troxler Carina , Kolbe Phil , Schiefner-Rohs Mandy
Published: February 2023

Der Beitrag untersucht ethnographisch und aus einer praxistheoretischen «doing difference»-Perspektive, wie soziale Differenz während der pandemiebedingten Aussetzung der schulischen Präsenzpflicht im Jahr 2020 durch Familien in diskursiven Praktiken hergestellt wird. Wir legen ein besonderes Augenmerk auf die Frage, wie soziale Ungleichheiten durch Akteur:innen der «Zuhause-Schule» konstruiert werden. Zur empirischen Erweiterung deskriptiver und quantitativer Forschungsperspektiven haben wir während der Schulschliessungen die familiäre Umsetzung von schulischen Lernofferten im Rahmen von teilnehmenden Beobachtungen in den Blick genommen, um (Neu-)Konstruktionen des häuslichen Alltags nachzuzeichnen. Die Interpretation des Datenmaterials erfolgte unter der Fragestellung, wie sich Unterricht aufgrund der Aussetzung des Präsenzunterrichts im häuslichen Alltag zeigt. Die Praktiken wurden in Anlehnung an sequenzanalytische Verfahren rekonstruiert. Im Anschluss an bisher vorliegende quantitativ-deskriptive Ergebnisse der Ungleichheitsforschung zu den pandemiebedingten Schulschliessungen arbeiten wir mit einem qualitativen Fokus heraus, dass die von uns begleiteten Familien drei Differenzlinien als besonders relevant adressieren: das Vorhandensein eines sehr spezifischen Sets an technischer Ausstattung, die Möglichkeiten der Eltern, Lernprozesse zu unterstützen, und die privaten sozialräumlichen Gegebenheiten.
Computer Analysis of New Language Norms Usage in Ukrainian Online Mass-Media
Authors: Steblyna Nataliia , Boryshchuk Vladyslav
Published: February 2023

Introduction. In 2019, a new version of spelling was approved in Ukraine. However, Ukrainian mass media experiences some problems with the new norms. Meanwhile, the correct usage of language in mass media is extremely important, because journalistic texts have a large audience and can be used by readers as a certain model. Thus, it’s important to discover specifics of new norms usage in online mass media to understand the level of the norms compliance.
Relevance and purpose. The purpose of the article is to propose an algorithm for computer analysis of texts, which allows to investigate compliance with new spelling norms by leading Ukrainian online media, as well as to determine whether the situation in the media changes over time. This study is relevant, because a comprehensive study of the new language norms usage in online massmedia is lacking, scientists focused their attention on individual norms and the number of texts in sample wasn’t large.
Methodology. Computer analysis: with Python programs more than 8 thousand news items were collected from the leading online media. Vocabularies with old and new language norms were designed. Comparative analysis: usage of foreign components, variable spelling changes, spelling of the international sites and Internet resources, spelling of certain words were compared in the mass media in 2019 and 2021.
Results. It was determined that the authors of the publications did not adapt to the variable spelling changes. Regarding mandatory changes, problems were observed with the spelling of the names of international websites and Internet resources, as well as some words. The situation with the use of feminine forms was the most stable. Spelling of words with the first foreign component, as well as with part «half/piv-» was observed in two versions: old and new spelling.
Conclusions. The situation with the new spelling in Ukrainian online media is improving over time, although the acceptance of the new norms is still very slow. Moreover, this situation is observed precisely in the segment of quality Ukrainian media, which adhere to professional standards and are an example for many journalists to follow. With this in mind, we recommend that the editors of the online mass-media take measures to improve the situation.
Demonic images in modern ukrainian advertising
Authors: Kravchenko Olena , Manych Nataliia , Fiedotova Nataliia
Published: February 2023

Introduction. Modern advertising reflects the cultural and historical processes taking place in Ukrainian society, in particular the establishment of the national identity of Ukrainians, which peaked in 2014 – the beginning of Russia’s armed aggression against Ukraine. Dissociation from foreign cultural traditions led to the appearance of Ukrainian demonic images in advertising – a mavka, a woodcutter, a chugaister, etc. The emotional upheaval of Ukrainians with the start of active hostilities in 2022 led to the transformation of the characters of lower mythology, who acquired the positive characteristics of Ukrainian land’s defenders. Relevance of the study. The evolution of demonic images in modern Ukrainian advertising from purely traditional to hyperbolically attractive representatives of the Ukrainian nation, the study of personified spirits of nature as a mechanism for popularizing traditional Ukrainian values appears to us to be relevant and in need of academic attention. The purpose of the article is to investigate the use of demonic images in modern Ukrainian advertising, to outline the evolution of advertising characters representing lower mythology in accordance with society’s requests for ethnic self-identification.
Methodology. The article uses general scientific methods of generalization, comparison, systematization, the structural-semiotic approach at the semantic and pragmatic levels, and the hermeneutic approach. The analysis was conducted using visual methods, in particular, iconological interpretation, linguosemiotic analysis, descriptive method. The study of mythological images in relation to their modern embodiment was carried out with the help of the cultural method, namely, the method of problematization of empirical material, comparison of basic images of demons with modern visual interpretations.
Results. Ukrainian advertisers adopted the globalization trend of changing the semantic content of the demonic image from negative to positive, attributive demonologizing of advertising characters, whose mystical essence does not cause disgust, since their negative influence is directed at the advertised product. With the beginning of the Russian aggression in Ukraine, representatives of Ukrainian lower mythology appear in advertising, which illustrates the radical changes in society as the formation of national identification, group psychological integrity, the formation of a national model of Ukrainian society.
Conclusions. Mythological characters in modern Ukrainian advertising have acquired positive features as a response to the fight against new evil forces in the form of Russian invaders. Demonic images, traditional for the Ukrainian worldview, appear as representatives of their land, who have magical power and are able to protect their own territory, Ukrainian cultural traditions from destruction. This indicates a change in narratives in Ukrainian advertising: it gradually becomes a translator of national values, a powerful mechanism of patriotic education.
Research Status and Trends of Taxodium distichum
Authors: Guo Jinbo , Xue Jianhui , Hua Jianfeng , Yin Yunlong , Creech David L. , Han Jiangang
Published: February 2023

In the context of intensified global climate change, Taxodium distichum has been attracting attention as an essential wetland plant. Through the literature visualization analysis software CiteSpace, the Spatial Distribution, Journal Distribution, Research Power, research status, and trends of T. distichum. The main conclusions are as follows. 1) The United States and China are the major countries for T. distichum research. The major institutions are Louisiana State University and the US Geological Survey. 2) The popular research areas mainly include growth, response, wetland, forest, climate change, adventitious root, and soil. 3) The research trends are soil and Florida (1992–98), survival (1999–2005), T. distichum (2006–12), salinity (2018–22), and sea-level rise (2020–22). These findings offer the current research status of T. distichum and could provide reference information for scholars in related fields to determine research directions and refine issues.
The impact of technostress on organizational functioning
Authors: Bencsik Andrea , Juhász Tímea
Published: February 2023

Research in recent years has shown that IT-enabled companies have higher productivity than their competitors. The new and latest technological solutions enrich the range of tools available to workers, ensuring that information is always available, communication is easier, and customers are better served. At the same time, these opportunities also create psycho-social pressures that strain workers’ working and private lives and can lead to further problems of techno-addiction. The study aims to investigate the relationships between the characteristics of technostress and their combined impact on trust within the organization between human-human and human-technology relationships. The quantitative study involved 531 respondents. Responses were analyzed using IBM SPSS 28 and IBM AMOS 27. The results show that there is undoubtedly a close relationship and a mutually generating effect between technostress characteristics, which substantially impact trust within the organization. However, trust is still stronger in personal relationships than in human-technology relationships. According to the respondents, the level of preparedness, technological knowledge, and expectations influence trust in the use of technology, which also affects performance and work-life balance.
AcknowledgmentThis study is supported by the Research Centre at Faculty of Business and Economics (No. PE-GTK-GSKK A095000000-4) of University of Pannonia (Veszprém, Hungary).
Maska i labirynt. O procesie indywiduacji zbiorowej w Amarcord Federica Felliniego
Authors: Tomczyk-Jarzyna Izabela
Published: February 2023

The article focuses on selected aspects of Amacord’s film and tries to answer the question why the characters of Fellini’s film were unable to meet their shadow and complete the process of individuation (as defined by C.G. Jung), and whether the diagnosis made by the director with regard to his characters indicates an opportunity, so that the viewer could avoid such blindness. Searching for answers to these questions, I use the anthropological category of labyrinth and mask. I agree with the way of perceiving and defining the concept of fascism proposed by Nicola Chiaromonte.
„Wybór twarzy” − spotkanie Federica Felliniego i Diane Arbus w świetle semantycznych wizji ludzkich fizjonomii
Authors: Ziemlewska Katarzyna
Published: February 2023

This research focuses on two famous artists born in the 20s of the 20th century who have been rarely brought together in comparison. It’s quite astonishing, as – putting aside the discrepancy of their respective biographies – the landscapes made of human faces in their oeuvre have much in common both aesthetically and semantically. As Fellini said in one of his interviews, “I look for my movies in all of the faces that are surrounding me”. The eponymous “selection of faces” was the most important part of the movie castings for the director from Rimini. He was eager to behold all of his upcoming films “in the appearing faces”. Proceeding from face semiology, the etymology of an Ancient Greek πρόσωπον meaning concurrently a “person” and a “mask”, and the problem of mimesis, this paper attempts to analyze the affinity of human physiognomies seen in the movies of Frederico Fellini and in the photographic portraits taken by Diane Arbus. The key to understanding their relatedness seems to be an explicit objection against “democracy of faces”, a withdrawal from staging the human visage to make it more expressive and unconstrained, and the conviction that “a face is not in the camera,” but it resides in the creator’s mind initially.
Wielki mały człowiek w bikornie. O ikonografii potęgi i upadku Napoleona na kartach pocztowych z pierwszych dekad XX wieku
Authors: Pawłowska-Jądrzyk Brygida
Published: February 2023

The huge popularity of mass-produced images of Napoleon Bonaparte (lithographs, statuettes, busts, plates etc.) lasted throughout the 19th century until 1914 in many countries. It can be assumed that the vitality of these trends in the popular circulation of culture at the beginning of the 20th century until the outbreak of World War I is evidenced by illustrations reproduced on postcards, which are then gaining more and more recognition as a new form of interpersonal communication and as a collector’s item. The author of the article analyzes the postcard representations of Napoleon, paying special attention to the symbolic aspects of the headgear in which the great Corsican was presented. Napoleon fascinated as a great leader, but also as a “fallen colossus”. The article shows, inter alia, that ever since the romanticism human imagination succumbed to the mocking vision of Bonaparte’s lonely end on a distant island. Such representations, very widespread thanks to postcards at the beginning of the 20th century, inevitably transform the defeat, suffering and death of a fallen hero into a “sentimental idyll”, making Napoleon one of the most powerful rulers of the collective imagination and, in a sense, the king of kitsch.
O muzyce w czasach pandemii COVID-19: socjologiczna interpretacja zmiany praktyk muzycznych na poziomie wykonawczym i odbiorczym
Authors: Jabłońska Barbara
Published: February 2023

The article aims to present the issues of musical practices in the times of the COVID-19 pandemic. The SARS-CoV-2 virus has completely disrupted the lives of people around the world, also hitting the world of music with force. The main axis of consideration is the belief in the social and communicative nature of music and the essence of musical practices in the collective dimension of human existence. The pandemic reality turned out to be a specific testing ground for these practices – which contributed significantly to the modification of human activities. The theoretical underpinning of the considerations is Stanisław Ossowski’s reflections on the communicative value of a musical work and elements of Alfred Schütz’s theory regarding the interactive dimension of musical practices. The article discusses such important aspects of people’s musical practices in pandemic times as their digitization and networking, social norms and rituals, artist-artist and artist-audience relations in the virtual world, domestication of musical practices, or epidemic rules. The whole discussion is guided by the assumption of the extraordinary social power of music, referring to the reflection on music and society as perceived by Karol Szymanowski and Arthur Schopenhauer. The conclusion of the article leads to the belief that the world of music will not be the same as before the pandemic, and hybrid solutions for combining virtual music practices with traditional ones (face-to-face) will certainly contribute to dynamic changes in the musical culture of societies around the world.
The Second Coming in the Wicked House: Pablo Larraín’s "El Club" (2015)
Authors: Ziółkowski Grzegorz
Published: February 2023

The article explores the 2015 Chilean drama film El Club, director Pablo Larraín’s investigation of the efforts undertaken by the Roman Catholic Church to conceal the abuses and crimes perpetrated by its officials. It also interrogates the sociopolitical context of the production, defined by the culture of impunity cultivated by Chile’s conservative establishment. The text presents an in-depth examination of the film’s plot, conceived as the primary conduit for meaning, and emphasizes the picture’s artistic dimension. It also offers an interpretation of the film that sees it as a manifestation of Pope Francis’ appeal to see Christ in the faces of the victims of the clergy’s sexual transgressions. Ultimately, the film harmonizes with the choir of voices which demand reexamination of the modern Catholic praxis, including the misuse of sacraments such as confession and absolution and, more generally, the virtue of mercy.
문화적 기억과 성사
Authors:   The Society of Theology and Thought, Markl SJ Dominik , 조 원형
Published: February 2023

This article relates the theory of cultural memory, with special reference to the work of Jan and Aleida Assmann, to the sacramental rituals. In particular, it emphasizes the entanglement of sacred texts with rites that make the transmission of cultural memory especially effective. By analysing the institutions of the Passover in Exodus 12 and the Eucharist in the New Testament, especially in 1 Corinthians 11 and Luke 22, the article demonstrates several common linguistic features as prerequisites for actualizing performance. The narrative settings of the institutions in Exodus and in the Passion of Jesus show that both the Passover and the Eucharist convey the memory of cultural trauma and its resilient transformation. Both rituals have accompanied Judaism and Christianity as migratory companions through history.
Ferric Carboxymaltose-mediated Methemoglobinemia
Authors: Özbilen Muhammet , Savrun Şeyda Tuba , Aygün Ali , Kaya Yasemin
Published: February 2023

Background:

Methemoglobinemia is a life-threatening disorder, with levels above 1
percent considered abnormal and typically resulting from drug or toxic substance exposure.

Case Presentation:

In this study, we describe a case of a 43-year-old woman with a long-standing
complaint of fatigue. Iron deficiency anemia was diagnosed based on the blood test findings of
hemoglobin of 101 g/L, mean red blood cell volume of 75 fL, ferritin of 2.81 ug/L, transferrin saturation
of 4.3 percent, and C-reactive protein of 0.6 mg/L. As a preferred treatment option, 1000 mg
ferric carboxymaltose on two distinct days was preferred. After administering the first dose of the
medication, we noticed incidentally that methemoglobin levels increased to 2.3%. When venous
blood gas was repeated before and after administration of the second dose of the drug, methemoglobin
levels were found to be 0.8% and 1.8%, respectively. There was no change in vital signs in
both two dosages, and she only suffered a temporary sore throat. Her anemia improved with intravenous
iron therapy, and she is currently being followed in our clinic.

Discussion:

No case or research reporting an increase in methemoglobin levels following oral
and/or intravenous treatment to patients with iron deficiency anemia has been found in the literature.
Therefore, this is the first contribution to the existing literature.
Cognitive moral: Merangsang perkembangan perilaku moral siswa sekolah dasar melalui pendekatan kognitif
Authors: Prihandoko Yogi
Published: February 2023

Perkembangan teknologi informasi yang cepat menjadi kekhawatiran orang tua pada saat anak-anak tidak bisa melepaskan ketergantungan dari kemudahan yang ditawarkan teknologi. Pendidikan moral di sekolah memiliki peran yang vital, saat kesibukan orang tua serta kecepatan penyebaran informasi dapat dengan mudah meracuni moral anak. Cognitive moral menjadi salah satu solusi tepat untuk membelajarkan moralitas. Pendekatan cognitive moral merupakan pembelajaran moral yang menekankan pada aspek penalaran dan pengambilan keputusan-keputusan untuk pemecahan masalah yang berkaitan dengan moral. Pengambilan keputusan tersebut tidak hanya didasarkan pada pilihan dan pemikiran spontanitas, namun menuntut pertimbangan yang merupakan proses kognisi kompleks. Tujuan dari pendekatan ini adalah merangsang perkembangan penalaran moral siswa menuju jenjang di atasnya sampai menuju kematangan moral. Kohlberg konsisten merumuskan teori tingginya penalaran moral seseorang berdampak pula pada kematangan moral, termasuk pada komponen tindakan (acting) dan perhatian (caring) moralnya. Operasionaliasi pendekatan ini dalam pembelajaran adalah menggunakan pengembangan cerita dilematis moral yang sesuai dengan taraf perkembangan siswa serta konteks kehidupan sehari-hari.
Information and Measurement System for Monitoring Beams in Building Structures
Authors: Loktionov A. P.
Published: February 2023

Purpose of research. The development of a method and algorithm for reducing measurements of beam identification parameters in an information and measurement system for monitoring building structures with measurement of deflections and recovery of actual values of beam initial parameters and external load when solving the inverse Cauchy problem.

Methods. The solution of the problem is carried out through formulating the transverse bending of the beam according to the Euler – Bernoulli theory using the method of regularization and reduction of measurements by solving the inverse Cauchy problem by means of linear Lagrangian approximation in the procedure of numerical differentiation of the beam deflection function. A methodology is formulated for identifying insignificant beam identification parameters by comparing the deflection of the beam caused by the parameter under study with the sensitivity threshold of measuring instruments. In this case, the modification of the state space of identification parameters with a decrease in its dimension is simulated.

Results. The working capability of the formulated experimental calculation method is confirmed by numerical experiment with a load on the beam in the form of a bending moment, concentrated and (or) constant distributed load. It has been established that when identifying insignificant initial parameters and loads acting on the beam, the reduction of measurements increases the accuracy of restoring the beam identification parameters.

Conclusion. The developed methodology can be used to improve the accuracy of inspection methods of construction facilities at the stage of experimental and theoretical research.
Non-Newtonian Fluid Flow Modeling in the Inertial Viscometer with a Computer Vision System
Authors: Kornaeva E. P. , Stebakov I. N. , Kornaev A. V. , Dremin V. V.
Published: February 2023

Purpose of research. Development of theoretical premises for the new inertial viscometer, as well as the development of an approximate model of the viscosity fluid flow using convolutional neural networks and laser speckle contrast imaging data.Methods. The study consists of two parts. The first is devoted to a theoretical study of viscosity fluid flow in the toroidal channel of еру new inertial viscometer. The mathematical model of the flow includes the dimensionless equations of Navier-Stokes and convective heat conduction, the analysis of which made it possible to estimate the conditions for the uniformity of pressure and temperature fields. The numerical solution of the simplified Navier-Stokes equation was obtained by the control volume method. The computational experiment made it possible to identify additional operating conditions for the viscometer. The second part of the research is aimed at solving the problem of predicting the values of the shear strain rate on the tour surface and the flow rate. The approximate flow model is based on an ensemble of convolutional neural networks trained on data from laser speckle-contrast visualization of a fluid flow in a transparent tube.Results. The recommendations on the operating parameters of the inertial viscometer for the studied types of liquids in a given viscosity range are obtained. An approximate model has been developed in the form of an ensemble of deep neural networks, which makes it possible to determine the volumetric flow rate and the shear strain rate on the flow surface based on fluid flow images.Conclusion. The approximate Navier-Stokes equation obtained as a result of theoretical analysis for the flow of a viscous fluid in a toroidal channel can be used to numerical determination the kinematic viscosity. So, the necessary flow characteristics, such as volumetric flow rate and shear strain rate on the flow surface, can be found using the developed and pretrained convolutional neural network based on laser speck contrast imaging data. The test fluid can be any non-Newtonian fluid capable of reflecting coherent radiation. In particular, it can be physiological fluids, including blood.
Increased Performance of Transformers Language Models in Information Question and Response Systems
Authors: Galeev D. T. , Panishchev V. S. , Titov D. V.
Published: February 2023

Purpose of research. The purpose of this work is to increase the performance of question and response information systems in Russian. Scientific novelty of the work is to increase the performance for RuBERT model, which was trained to find the answer to the question in the text. As far as a more efficient language model allows more requests to be processed in the same time, the results of this work can be used in various information question and response systems for which response speed is important.

Methods. The present work uses methods of processing natural language, machine learning, reducing the size of artificial neural networks. The language model was configured and trained using Torch and Onnxruntime machine learning libraries. The original model and training dataset were taken from the Huggingface Library.

Results. As a result of the study, the performance of RuBERT language model was increased using methods to reduce the size of neural networks, such as distillation of knowledge and quantization, as well as by exporting the model to ONNX format and running it in ONNX runtime.

Conclusion. As a result, the model, to which knowledge distillation, quantization and ONNX optimization were simultaneously applied, received a performance increase of ~ 4.6 times (from 66.57 to 404.46 requests per minute), while the size of the model decreased ~ 13 times (from 676.29 MB to 51.66 MB). The downside of obtained performance was EM deterioration (from 61.3 to 56.87) and F-measure (from 81.66 to 76.97).
Multicriteria Optimization of Design Solutions for Microclimate Systems for Rooms with Artificial Ice
Authors: Chuykin S. V. , Kutsygina O. A.
Published: February 2023

Рurpose of research. The most energy-intensive facilities for holding sports and cultural events are indoor ice rinks and ice arenas. Simplified technical solutions when designing the systems for providing the microclimate of these structures lead to significant operating costs and can lead to serious negative consequences in a relatively short period. In this regard, the problem of developing methods for choosing the optimal design solution for these systems is becoming ever more urgent. The purpose of the article is to develop a mathematical model for multi-criteria optimization of design solutions for systems providing the microclimate of rooms with artificial ice.

Methods. Determining the optimal design solution for microclimate systems in terms of several parameters, each of which can be decisive, is an applied task of system analysis, the basic principles and patterns of which were taken into account when solving the problem of multicriteria optimization.

Results. A list of particular optimality criteria reflecting the qualitative and quantitative characteristics of design solutions has been determined. The method of vector criterion convolution has been used to search for the optimal solution for the selected particular criteria. An optimization model based on the principles of system analysis has been developed.

Conclusion. The developed mathematical model of multicriteria optimization makes it possible to provide priority to more important particular criteria by increasing their weights. In this case, it should be remembered that particular criteria must be commensurate, and, therefore, reduced to a dimensionless form. Since the absolute values of the criteria are essential in the optimization task under consideration, for the chosen vector of parameters, it is necessary to choose exactly the additive method of folding the generalized criterion.
Study of Vibration Strength of D16 Aluminum Alloy Joints Welded Applying Resistance Spot Welding
Authors: Balashov S. A. , Zezyulya V. V. , Bulychev V. V. , Ageeva E. V.
Published: February 2023

Purpose of research is to develop and test a technique and perform an experimental study of the vibration strength of D16 aluminum alloy joints welded applying resistance spot welding.

Methods. Test coupons were made from 1 mm thick D16 aluminum alloy sheet blanks applying resistance spot welding. A feature of the proposed test is the implementation of a symmetrical loading cycle. During the tests, the number of cycles to failure depending on the range of vibrations was recorded. Annealing and thermomechanical straightening were carried out to exclude helical bending after cutout. After deburring and root facing, the surface of the coupons was prepared for welding using chemical etching. The coupons were welded using a TECNA 8214N spot welding machine. The welding current was 30 kA, the welding duration was 0.1 s, the electrodes force was 180 daN. The static shear strength of the welded joint was studied using a UTS 110M-5 1-U tensile testing machine. The breaking force was 3.66 kN. The peculiarity of the proposed test is the implementation of a symmetrical loading cycle. During the tests, the number of cycles to failure depending on the range of vibrations was recorded.

Results. As a result of the statistical analysis of the study results, a linear mathematical relationship between the logarithms of the number of cycles to failure and the amplitude of vibrations was obtained. Depending on the range of vibrations, characteristic zones of destruction were revealed. To provide the possibility of comparing the results of vibration obtained under different conditions of fixing the samples, it is proposed to use the range of vibration displacement per unit length of the work[iece as the ordinate.

Conclusion. A technique or studying the vibrational strength of joints welded by resistance spot welding under conditions of a symmetrical loading cycle is proposed and tested. For the studied coupons, the equality of the welded joint to the base metal is achieved at the value of the logarithm of the ratio of the range of vibration displacement per unit length of the coupons equal to 0.01.
El reto de extraer ADN y no morir en el intento
Authors:   ‎‎Corporación colombiana de investigación agropecuaria, Mosquera (Colombia)
Published: February 2023

En este capítulo el YouTuber Del Agro aceptó el reto de tomar una muestra de sangre a un bovino y extraerle el ADN. Lo logra o no lo logra? No se lo pierda.
Prácticas culturales del cultivo del plátano
Authors: Rodríguez Yzquierdo Gustavo , Miranda Salas Tatiana Camila , Posada Velásquez Luisa Fernanda
Published: February 2023

Este vídeo hace parte de una estrategia de transferencia de tecnología para fomentar la diversificación de la economía regional en el marco del convenio AGROSAVIA-Ecopetrol da a conocer información clave sobre el manejo agronómico del material vegetal en el cultivo de plátano.
El riego con agua tratada de producción de la industria del petróleo y la biodiversidad
Authors: Almansa Manrique Edgar Fernando , Velásquez Penagos José Guillermo , Luna Mora Victor Fabio
Published: February 2023

En el piedemonte del Meta se viene desarrollando un proyecto de investigación liderado por AGROSAVIA y Ecopetrol donde se estudian los efectos de usar las aguas de producción de la industria de hidrocarburos en campo Castilla como riego en sistemas agropecuarios.
Modelo de evaporación híbrido para la producción de panela
Authors:   ‎‎Corporación colombiana de investigación agropecuaria, Mosquera (Colombia)
Published: February 2023

La producción de panela en Colombia, a evolucionado conforme se introducen nuevas tecnologías en el proceso, sin embargo las familias paneleras tradicionales, continúan con oportunidades de mejora en la transferencia de calor, consumos y calidad del producto.
Riego de especies forestales con agua de producción tratada
Authors: Almansa Manrique Edgar Fernando , Velásquez Penagos José Guillermo , Luna Mora Victor Fabio
Published: February 2023

En el piedemonte del Meta se viene desarrollando un proyecto de investigación liderado por AGROSAVIA Y Ecopetrol que estudia el manejo del agua en plantaciones forestales, consiste en utilizar el agua de producción tratada que cumple con la reglamentación legal ambiental para riego y potencializarla como un recurso en sistemas agropecuarios con miras a disminuir su disposición directa en cuerpos de agua y a explorar una opción de uso sostenible.
Indigenous Food Systems Changes and Resiliency: Protocol for a Scoping Review
Authors: Monteith Hiliary , Hiscock Elizabeth Claire , Sadeghi Yasamin , Smith Emily V , Mashford-Pringle Angela
Published: February 2023

Background

Indigenous food systems (IFS) consider the complex relationships and connections between land, animals, plants, water, and people. These food systems may differ between regions, Indigenous cultures, and history; however, given the similar colonial histories and policies influencing Indigenous groups in Canada, the United States, Australia, and Aotearoa (New Zealand), the IFS changes and responses in these regions may follow similar trends. Climate change and pollution continue to impact the environment in catastrophic ways, and this, in turn, impacts IFS. However, to date, there has been no review of the literature on IFS, how they are changing, and how communities are responding to these changes.

Objective

In this scoping review, we will summarize primary research in Canada, the United States, Australia, and Aotearoa related to IFS addressing the following questions: (1) What changes are IFS experiencing in the context of climate change and pollution? (2) What actions have been taken in response to IFS changes? (3) What are the characteristics of IFS research in peer-reviewed academic literature?

Methods

We will use the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for scoping reviews and the Joanna Briggs Institute reviewer’s manual to inform the review process. MEDLINE, SCOPUS, International Bibliography of the Social Sciences, Sociological Abstracts, and the Bibliography of Native North Americans are the databases included in this review search. All screening and extraction have been supported by Covidence software (Veritas Health Innovation) with 2 independent reviewers conducting the abstract and full-text screening. We will map concepts and themes related to the research questions to contribute to the understanding of IFS within the academic literature and provide a narrative review of the outcomes.

Results

The electronic database searches for this review were conducted in May 2021. Screening and full-text review were initially completed in the winter of 2022. We are currently in the process of compiling results and aim to share findings in 2023.

Conclusions

This review will provide valuable insight into current IFS needs by summarizing the peer-reviewed literature on how IFS are changing because of climate change and pollution and how communities are responding to these changes. The results of this review will be shared with Indigenous communities, through academic publications, community conversations, and conference presentations.

Trial Registration

OSF Registries osf.io/xrj87; https://osf.io/xrj87

International Registered Report Identifier (IRRID)

RR1-10.2196/41627
Teaching Principles of Medical Innovation and Entrepreneurship Through Hackathons: Case Study and Qualitative Analysis
Authors: Preiksaitis Carl , Dayton John R , Kabeer Rana , Bunney Gabrielle , Boukhman Milana
Published: February 2023

Background

Innovation and entrepreneurship training are increasingly recognized as being important in medical education. However, the lack of faculty comfort with the instruction of these concepts as well as limited scholarly recognition for this work has limited the implementation of curricula focused on these skills. Furthermore, this lack of familiarity limits the inclusion of practicing physicians in health care innovation, where their experience is valuable. Hackathons are intense innovation competitions that use gamification principles to increase comfort with creative thinking, problem-solving, and interpersonal collaboration, but they require further exploration in medical innovation.

Objective

To address this, we aimed to design, implement, and evaluate a health care hackathon with 2 main goals: to improve emergency physician familiarity with the principles of health care innovation and entrepreneurship and to develop innovative solutions to 3 discrete problems facing emergency medicine physicians and patients.

Methods

We used previously described practices for conducting hackathons to develop and implement our hackathon (HackED!). We partnered with the American College of Emergency Physicians, the Stanford School of Biodesign, and the Institute of Design at Stanford (d.school) to lend institutional support and expertise in health care innovation to our event. We determined a location, time frame, and logistics for the competition and settled on 3 use cases for teams to work on. We planned to explore the learning experience of participants within a pragmatic paradigm and complete an abductive thematic analysis using data from a variety of sources.

Results

HackED! took place from October 1-3, 2022. In all, 3 teams developed novel solutions to each of the use cases. Our investigation into the educational experience of participants suggested that the event was valuable and uncovered themes suggesting that the learning experience could be understood within a framework from entrepreneurship education not previously described in relation to hackathons.

Conclusions

Health care hackathons appear to be a viable method of increasing physician experience with innovation and entrepreneurship principles and addressing complex problems in health care. Hackathons should be considered as part of educational programs that focus on these concepts.
Using natural language processing and structured medical data to identify patients hospitalized due to COVID-19 (Preprint)
Authors: Chang Feier , Krishnan Jay , Hurst Jillian H , Yarrington Michael E , Anderson Deverick J , O'Brien Emily C , Goldstein Benjamin Alan
Published: February 2023

BACKGROUND

Throughout the COVID-19 pandemic, many hospitals conducted routine testing of hospitalized patients for SARS-CoV-2 infection upon admission. Some of these patients are admitted for reasons unrelated to COVID-19, and incidentally test positive for the virus. Because COVID-19-related hospitalizations have become a critical public health indicator, it is important to identify patients who are hospitalized because of COVID-19 as opposed to those who were admitted for other indications.

OBJECTIVE

We compared the performance of different computable phenotype definitions for COVID-19 hospitalizations that use different types of data from the electronic health records (EHR), including structured EHR data elements, provider notes, or a combination of both data types.

METHODS

We conducted a retrospective data analysis utilizing chart review-based validation at a large academic medical center. We reviewed and analyzed the charts of 586 hospitalized individuals who tested positive for SARS-CoV-2 during January 2022. We used LASSO regression and Random Forests to fit classification algorithms that incorporated structured EHR data elements, provider notes, or a combination of structured data and provider notes. We used natural language processing to incorporate data from provider notes. The performance of each model was evaluated based on Area Under the Receiver Operator Characteristic (AUROC) and an associated decision rule based on sensitivity and positive predictive value. We also identified top words and clinical indicators of COVID-19-specific hospitalization and assessed the impact of different phenotyping strategies on estimated hospital outcome metrics.

RESULTS

Based on a chart review, 38% of 586 patients were determined to be hospitalized for reasons other than COVID-19 despite having tested positive for SARS-CoV-2. A classification algorithm that used provider notes had significantly better discrimination than one that used structured EHR data elements (AUROC: 0.894 vs 0.841, p < 0.001), and performed similarly to a model that combined provider notes with structured data elements (AUROC: 0.894 vs 0.893). Assessments of hospital outcome metrics significantly differed based on whether the population included all hospitalized patients who tested positive for SARS-CoV-2 versus those who were determined to have been hospitalized due to COVID-19.

CONCLUSIONS

These findings highlight the importance of cause-specific phenotyping for COVID-19 hospitalizations. More generally, this work demonstrates the utility of natural language processing approaches to derive information related to patient hospitalizations in cases where there may be multiple conditions that could serve as the primary indication for hospitalization.