bluuebunny/crossref_metadata_2025 huggingface dataset:
Co-use of MDMA with psilocybin/LSD may buffer against challenging experiences and enhance positive experiences
Authors: Zeifman Richard J. , Kettner Hannes , Pagni Broc A. , Mallard Austin , Roberts Daniel E. , Erritzoe David , Ross Stephen , Carhart-Harris Robin L.
Published: August 2023

Psilocybin and lysergic acid diethylamide (LSD) experiences can range from very positive to highly challenging (e.g., fear, grief, and paranoia). These challenging experiences contribute to hesitancy toward psychedelic-assisted psychotherapy among health care providers and patients. Co-use of 3,4-Methylenedioxy methamphetamine (MDMA) with psilocybin/LSD anecdotally reduces challenging experiences and enhances positive experiences associated with psilocybin/LSD. However, limited research has investigated the acute effects of co-use of MDMA and psilocybin/LSD. In a prospective convenience sample (N = 698) of individuals with plans to use psilocybin/LSD, we examined whether co-use of MDMA with psilocybin/LSD (n = 27) is associated with differences in challenging or positive experiences. Challenging experiences were measured using the Challenging Experiences Questionnaire and positive experiences were measured using the Mystical Experience Questionnaire and single-item measures of self-compassion, compassion, love, and gratitude. Potentially confounding variables were identified and included as covariates. Relative to psilocybin/LSD alone, co-use of psilocybin/LSD with a self-reported low (but not medium–high) dose of MDMA was associated with significantly less intense total challenging experiences, grief, and fear, as well as increased self-compassion, love and gratitude. Co-use of psilocybin/LSD and MDMA was not associated with differences in mystical-type experiences or compassion. Findings suggest co-use of MDMA with psilocybin/LSD may buffer against some aspects of challenging experiences and enhance certain positive experiences. Limitations include use of a convenience sample, small sample size, and non-experimental design. Additional studies (including controlled dose–response studies) that examine the effects and safety of co-administering MDMA with psilocybin/LSD (in healthy controls and clinical samples) are warranted and may assist the development of personalized treatments.
The role of TRPV2 as a regulator on the osteoclast differentiation during orthodontic tooth movement in rats
Authors: Shigemi Shohei , Sato Tadasu , Sakamoto Mayuri , Yajima Takehiro , Honda Takahiro , Tsumaki Hiroka , Deguchi Toru , Ichikawa Hiroyuki , Fukunaga Tomohiro , Mizoguchi Itaru
Published: August 2023

When orthodontic forces are applied to teeth, bone remodeling, which consists of bone resorption and bone formation, occurs around the teeth. Transient receptor potential vanilloid 2 (TRPV2) is a cation channel expressed in various cell types that responds to various stimuli, including mechanical stress, and involved in calcium oscillations during the early stages of osteoclast differentiation. However, in vivo expression of TRPV2 in osteoclasts has not yet been reported, and temporo-spatial expression of TRPV2 during osteoclast differentiation is unclear. In this study, we examined the TRPV2 expression during experimental tooth movement and assessed the effect of TRPV2 on osteoclast differentiation. TRPV2 was detected on day 1 after experimental tooth movement on the compression side, and the number of TRPV2-expressing cells significantly increased on day 7. These TRPV2-expressing cells had a single, or multiple nuclei and were positive for TRAP activity. Consistent with these in vivo findings, in vitro experiments using RAW264.7 osteoclast progenitor cells showed that TRPV2 mRNA was increased at the early stage of osteoclast differentiation and maintained until the late stage. Furthermore, a TRPV2 channel selective antagonist significantly inhibited osteoclast differentiation. These findings suggest that TRPV2 may have a regulatory role in osteoclast differentiation during orthodontic tooth movement.
Digital transformation of mental health services
Authors: Bond Raymond R. , Mulvenna Maurice D. , Potts Courtney , O’Neill Siobhan , Ennis Edel , Torous John
Published: August 2023

This paper makes a case for digital mental health and provides insights into how digital technologies can enhance (but not replace) existing mental health services. We describe digital mental health by presenting a suite of digital technologies (from digital interventions to the application of artificial intelligence). We discuss the benefits of digital mental health, for example, a digital intervention can be an accessible stepping-stone to receiving support. The paper does, however, present less-discussed benefits with new concepts such as ‘poly-digital’, where many different apps/features (e.g. a sleep app, mood logging app and a mindfulness app, etc.) can each address different factors of wellbeing, perhaps resulting in an aggregation of marginal gains. Another benefit is that digital mental health offers the ability to collect high-resolution real-world client data and provide client monitoring outside of therapy sessions. These data can be collected using digital phenotyping and ecological momentary assessment techniques (i.e. repeated mood or scale measures via an app). This allows digital mental health tools and real-world data to inform therapists and enrich face-to-face sessions. This can be referred to as blended care/adjunctive therapy where service users can engage in ‘channel switching’ between digital and non-digital (face-to-face) interventions providing a more integrated service. This digital integration can be referred to as a kind of ‘digital glue’ that helps join up the in-person sessions with the real world. The paper presents the challenges, for example, the majority of mental health apps are maybe of inadequate quality and there is a lack of user retention. There are also ethical challenges, for example, with the perceived ‘over-promotion’ of screen-time and the perceived reduction in care when replacing humans with ‘computers’, and the trap of ‘technological solutionism’ whereby technology can be naively presumed to solve all problems. Finally, we argue for the need to take an evidence-based, systems thinking and co-production approach in the form of stakeholder-centred design when developing digital mental health services based on technologies. The main contribution of this paper is the integration of ideas from many different disciplines as well as the framework for blended care using ‘channel switching’ to showcase how digital data and technology can enrich physical services. Another contribution is the emergence of ‘poly-digital’ and a discussion on the challenges of digital mental health, specifically ‘digital ethics’.
Fast Raman imaging through the combination of context-aware matrix completion and low spectral resolution
Authors: Jiang Ziling , Wang Xianli , Chu Kaiqin , Smith Zachary J.
Published: August 2023

We speed up Raman imaging by: using a bright field image to skip sample background regions; using matrix completion to sub-sample without sacrificing resolution; using “low resolution Raman” to improve SNR without sacrificing chemical specificity.
Solvent-free room-temperature synthesis of brightly luminescent [BMPyr]2[SnCl4]
Authors: Wolf Silke , Feldmann Claus
Published: August 2023

[BMPyr]2[SnCl4] can be prepared just by shaking the starting materials at room temperature and followed with the naked eye via its increasing deep-red emission. With optimised conditions intense emission with 88 ± 3% quantum yield occurs.
Electrochemical reductive cascade cyclization of o-alkynylated derivatives for saturated amides/amines
Authors: Reddy Mandapati Bhargava , Prabhu Sakthivel , Anandhan Ramasamy
Published: August 2023

Reductive cascade cyclization of o-alkynylated benzamides is achieved by electrochemical proton-coupled electron transfer (PCET). The in situ hydrogenation of olefins preceded via cathodic reduction without the use of any external reductants.
The dual role of eppin in immunity and biomineralization during nacreous layer formation in mollusks
Authors: Jin Can , Jiang Rui , Zhang Yihang , Cheng Kang , Luo Wen , Xie Guilin
Published: August 2023

The presence of protease inhibitors in a carbonated shell is intriguing and opens questions about their potential role in shell biomineralization.
Interface engineering strategy for multisource spintronic devicesviaTMPS4modulation of black-phosphorus
Authors: Wang Tongtong , Liu Fangqi , Liu Sheng , Liu Bin , Zhu Sicong
Published: August 2023

Diagram of the variation of the three energy band types, conductance, and binding energy of BP/TMPS4van der Waals heterojunctions.
Mechanistic insight into the effect of active site motif structures on direct oxidation of methane to methanol over Cu-ZSM-5
Authors: Dai Chengna , Zhang Yuchan , Liu Ning , Yu Gangqiang , Wang Ning , Xu Ruinian , Chen Biaohua
Published: August 2023

Direct oxidation of methane to methanol (DMTM), a highly challenging reaction in C1 chemistry, has attracted lots of attention.
A TiSe monolayer as a superior anode for applications of Li/Na/K-ion batteries
Authors: Wang Mengke , Wang Shan , Liang Yunye , Xie Yiqun , Ye Xiang , Sun Shoutian
Published: August 2023

TiSe monolayer possesses good thermal dynamic stability and conductivity. It shows high specific capacities of 423 mA h g−1 for Li/Na/K. Small ion diffusion barriers indicate a high-rate capability, making it a good candidate as anode material.
Non-volatile control of topological phase transition in an asymmetric ferroelectric In2Te2S monolayer
Authors: Song Guang , Wu Yangyang , Cao Lei , Li Guannan , Zhang Bingwen , Liang Feng , Gao Benling
Published: August 2023

In2Te2S monolayer is an asymmetric ferroelectric material, which can realize nonvolatile ferroelectric control of topological phase transition.
Electromechanical behaviour of violet phosphorene nanoflakes
Authors: Zhang Bo , Wang Zhenyu , Chen Chengxiang , Gu Mengyue , Zhou Jun , Zhang Jinying
Published: August 2023

The electromechanical behavior of vP nanoflakes is a mechanical–electrical–thermal coupling failure behavior.
PIO and IBO analysis to unravel the hidden details of the CO2 sequestration mechanism of aromatically tempered N/B-based IFLPs
Authors: Faizan Mohmmad , Kumar Adarsh , Raghasudha Mucherla , Pawar Ravinder
Published: August 2023

The PIO and IBO analysis shows the asynchronicity in the CO2 activation mechanism by aromatically enhanced N/B based Frustrated Lewis Pairs (FLPs).
Monolayer Ge2Te2P4 as a promising photocatalyst for solar driven water-splitting: a DFT study
Authors: Pham Trung D. , Hien Tong D.
Published: August 2023

Promising photocatalytic monolayer Ge2Te2P4 with a high absorption rate and charge carrier mobility.
Emergent superconductivity in TaO3 at high pressures
Authors: Li Wenjing , Li Xing , Zhang Xiaohua , Yu Hong , Han Fanjunjie , Bergara Aitor , Lin Jianyan , Wu Jinhui , Yang Guochun
Published: August 2023

A novel Pm3̄n TaO3 exhibits a superconducting behavior under high pressure, of which Tc increases gradually with the decreasing pressure.
The molecular mechanism of non-covalent inhibitor WU-04 targeting SARS-CoV-2 3CLpro and computational evaluation of its effectiveness against mainstream coronaviruses
Authors: Wu Jianhua , Zhang Hong-Xing , Zhang Jilong
Published: August 2023

A novel non-covalent inhibitor, WU-04, inhibits several mainstream coronaviruses and is a pan-inhibitor of 3CLpro.
Carbonic anhydrase mimics with rationally designed active sites for fine-tuned catalytic activity and selectivity in ester hydrolysis
Authors: Bahrami Foroogh , Zhao Yan
Published: August 2023

A synthetic mimic of carbonic anhydrase shows a lower pKa value for the zinc-bound water than the natural enzyme. As a result, it is able to hydrolyze nonactivated esters at pH 7.
Designing N-doped graphene-like supported highly dispersed bimetallic NiCoP NPs as an efficient electrocatalyst for water oxidation
Authors: Wang Jiabo , Fu Yalin , Zhang Peng , Zhang Jie , Ma Xusen , Zhang Jibo , Chen Li
Published: August 2023

Co/Ni bimetallic phosphides were synthesized using ion exchange resin, which endows them with the advantages of porosity and a large specific surface area.
A constant-current generator via water droplets driving Schottky diodes without a rectifying circuit
Authors: Li Yahui , Zhang Qi , Cao Yuhong , Kang Zhipeng , Ren Han , Hu Zhiyuan , Gao Mang , Ma Xiaole , Yao Jinyuan , Wang Yan , Zhang Congchun , Ding Guifu , Liu Junshan , Bao Jiming , Wang Hui , Yang Zhuoqing
Published: August 2023

This work highlights the regulation of an MSM Schottky barrier by the triboelectric potential, as well as many potential applications arising from this mechanism, including energy harvesters, droplet logic circuits, and fluid signal monitoring.
Enhanced depolymerization of beech wood lignin and its removal with peroxidases through continuous separation of lignin fragments
Authors: Teo Kenneth Sze Kai , Kondo Keiko , Saito Kaori , Iseki Yu , Watanabe Takashi , Nagata Takashi , Katahira Masato
Published: August 2023

A study highlighting the benefits associated with the continuous separation of MnP- (or LiP-) depolymerized lignin fragments from the reaction medium using a membrane bioreactor.
Blue applicability grade index (BAGI) and software: a new tool for the evaluation of method practicality
Authors: Manousi Natalia , Wojnowski Wojciech , Płotka-Wasylka Justyna , Samanidou Victoria
Published: August 2023

In this work, blue applicability grade index (BAGI) is proposed as a new metric tool for evaluating the practicality of an analytical method.
Photoinduced, additive- and photosensitizer-free multi-component synthesis of naphthoselenazol-2-amines with air in water
Authors: Ji Hong-Tao , Wang Ke-Li , Ouyang Wen-Tao , Luo Qing-Xia , Li Hong-Xia , He Wei-Min
Published: August 2023

An atom- and step-economical, efficient and eco-friendly method for constructing naphthoselenazol-2-amines through a visible-light photocatalytic multi-component reaction under aqueous phase conditions is reported.
Carbon materials for hybrid evaporation-induced electricity generation systems
Authors: Ge Can , Xu Duo , Qian Yan , Du Heng , Gao Chong , Shen Zhuoer , Sun Zhe , Fang Jian
Published: August 2023

The most recent developments in carbon materials for hybrid evaporation-induced electricity generation systems are discussed in detail and analyzed in depth.
Bimetallic NiCe/Lay catalysts facilitated co-pyrolysis of oleic acid and methanol for efficiently preparing anaerobic hydrocarbon fuels
Authors: Zhang Kai , Liu Xiangyi , Bi Jiajun , BaQais Amal , Xu Ben Bin , Amin Mohammed A. , Hou Ying , Liu Xianglong , Li Handong , Algadi Hassan , Xu Juan , Guo Zhanhu
Published: August 2023

Bimetallic NiCe/Lay catalysts were prepared and achieved a conversion rate of oleic acid of 100% and a hydrocarbon selectivity of 92.77%.
An aqueous electrolyte with up to 2.9 V operating voltage
Authors: Liu Danian , Peng Wenhai
Published: August 2023

The hydrophobic tail of Tween 20 array on the surface of the electrode concentrates an oil layer, extending the operating voltage.
Reduction of copper oxides by carbon monoxide at an applied potential
Authors: Dokhlikova Nadezhda V. , Gatin Andrey K. , Sarvadii Sergey Yu. , Ozerin Sergey A. , Kharitonov Vasiliy A. , Shub Boris R. , Grishin Maxim V. , Doronin Sergey V.
Published: August 2023

The negative potential promotes the reduction reaction of copper oxides by carbon monoxide in the gas phase.
A novel nanocomposite material C3F7-azo+/Ti4O92− was prepared as a sensor for the detection of ascorbic acid and uric acid
Authors: Zhou Yicheng , Dong Li , Cao Tongtong , Zhang Jiazheng , Qiao Rongrong , Liu Lin , Liu Chao , Zhang Xiaobo , Tong Zhiwei
Published: August 2023

A novel layered nanocomposite, C3F7-azo+/Ti4O9, was prepared using the stripping/restacking method with K2Ti4O9 as the raw material and C3F7-azo+Br− as the modifier.
1,1′-Carbonyldiimidazole-mediated transformation of allomaltol containing hydrazides into substituted 3-acetyltetronic acids
Authors: Komogortsev Andrey N. , Lichitskii Boris V. , Melekhina Valeriya G.
Published: August 2023

The first example of the recyclization of allomaltols containing a hydrazide fragment into 3-acyltetronic acids under the action of CDI.
Improving the durability of cobaltite cathode of solid oxide fuel cells – a review
Authors: Mehdi Ali Muqaddas , Hussain Amjad , Song Rak Hyun , Lim Tak-Hyoung , Kazmi Wajahat Waheed , Ishfaq Hafiz Ahmad , Khan Muhammad Zubair , Qamar SanaUllah , Syed Muhammad Wasi , Mehran Muhammad Taqi
Published: August 2023

Degradation of cobaltite cathode of solid oxide fuel cell and their durability improvement strategies.
Annealing-induced phase transformation in In10Se70Te20 thin films and its structural, optical and morphological changes for optoelectronic applications
Authors: Giri Sasmita , Priyadarshini P. , Alagarasan D. , Ganesan R. , Naik R.
Published: August 2023

Annealing induced structural, morphological and optical properties change in In10Se70Te20 thin films at different annealing temperatures.
A controllable surface etching strategy for MOF-derived porous ZnCo2O4@ZnO/Co3O4 oxides and their sensing properties
Authors: Li Wang , Guo Yulin , Liu Yan , Yang Wen , Hu Jifan , Ma Jiangwei
Published: August 2023

A surface etching strategy was proposed for the controllable synthesis of MOF-derived ZnCo2O4@ZnO/Co3O4 oxides, and the ZnCo2O4@ZnO/Co3O4-6 h sensor device exhibits the highest response and excellent selectivity to 100 ppm methanal at 200 °C.
Tube geometry controls protein cluster conformation and stability on the endoplasmic reticulum surface
Authors: Kischuck Liam T. , Brown Aidan I.
Published: August 2023

Stochastic simulations show that endoplasmic reticulum tube geometry impacts protein cluster dynamics and stabilityviacluster wrapping conformation effects.
A one-step facile process for extraction of cellulose from rice husk and its use for mechanical reinforcement of dental glass ionomer cement
Authors: El-Din Al-Mofty Saif , Elghazawy Nehal H. , Azzazy Hassan M. E.
Published: August 2023

The extraction of cellulose was optimized using only hypochlorite and characterized and then utilized as a filler in glass ionomer cement where its strength and elasticity were studied.
Composition and temperature influence on hydrogenation performance of TiZrHfMoxNb2–x high entropy alloys
Authors: Zhang J. W. , Zhou P. P. , Cao Z. M. , Li P. C. , Hu J. T. , Xiao H. Y. , Zhou X. S. , Shen H. H. , Zu X. T.
Published: August 2023

This study thoroughly investigates the influences of temperature and composition on the hydrogenation kinetic performance and discusses the hydrogen-induced phase transformation process at RT or high temperature of BCC TiZrHfMoxNb2–x (x = 0, 1, 2).
Single phase of perovskite YTaON2 synthesized for photocatalytic water reduction and oxidation under visible-light irradiation
Authors: Zou Hai , Bao Yunfeng , Du Shiwen , Xin Xueshang , Qi Yu , Shao Guosheng , Zhang Fuxiang
Published: August 2023

Single-phase perovskite-structured YTaON2 with a band gap of 2.1 eV was obtained for the first time by an enhanced nitriding kinetics method and its dual functionalities of water reduction and oxidation were proved.
Photoactivated plasmonic nanohybrid fibers with prolonged trapping of excited charge carriers for SERS analysis of biomolecules
Authors: Sharma Arti , Ahuja Tripti , Yadav Jatin , Majumdar Shubhangi , Siddhanta Soumik
Published: August 2023

Pre-activation of SERS plasmonic substrate with UV light leads to the creation of long-lived charged states resulting in better attachment of proteins and an increase in the SERS chemical enhancement.
Optimizing the hybrid PVDG and DSTATCOM integration in electrical distribution systems based on a modified homonuclear molecules optimization algorithm
Authors: Belbachir Nasreddine , Kamel Salah , Hashim Fatma A. , Yu Juan , Zeinoddini‐Meymand Hamed , Sabbeh Sahar F.
Published: August 2023

The increasing use of non‐linear loads in electrical distribution systems (EDS) led to a greater need for reactive power compensation, losses minimization, improved voltage and stability. This paper proposes the optimal integration of hybrid photovoltaic distributed generation (PVDG) and distribution static synchronous compensator (DSTATCOM) into IEEE 33 and 69‐bus EDS. A modified version of homonuclear molecules optimization (mHMO) is developed to determine the optimal allocation of the devices, while minimizing a multi‐objective function (MOF) based on total active power losses (TAPL), total voltage deviation (TVD), and investment cost of integrated devices (ICPVDG and ICDSTATCOM). The primary objective of the mHMO is to enhance the equilibrium between exploration and exploitation in the original HMO by implementing a fresh exploration stage. The effectiveness of mHMO was assessed using CEC17 benchmark functions. The findings demonstrate that mHMO achieved excellent results, including high‐quality solution and a favourable convergence rate. Additionally, results demonstrate that mHMO outperforms its basic version in reducing TAPL by 94.27% and 97.87% for the two EDS, while improving voltage profiles and reducing the cost of integrated devices. This study shows the potential of hybrid PVDG‐DSTATCOM in improving the performance of EDS and highlights the effectiveness of mHMO in optimizing their integration.
Pre-merger alert to detect prompt emission in very-high-energy gamma-rays from binary neutron star mergers: Einstein Telescope and Cherenkov Telescope Array synergy
Authors: Banerjee Biswajit , Oganesyan Gor , Branchesi Marica , Dupletsa Ulyana , Aharonian Felix , Brighenti Francesco , Goncharov Boris , Harms Jan , Mapelli Michela , Ronchini Samuele , Santoliquido Filippo
Published: August 2023

The current generation of very-high-energy gamma-ray (VHE; E > 30 GeV) detectors (MAGIC and H.E.S.S.) have recently demonstrated the ability to detect the afterglow emission of gamma-ray bursts (GRBs). However, the GRB prompt emission, typically observed in the 10 keV–10 MeV band, is still undetected at higher energies. Here, we investigate the perspectives of multi-messenger observations to detect the earliest VHE emission from short GRBs. Considering binary neutron star mergers as progenitors of short GRBs, we evaluate the joint detection efficiency of the Cherenkov Telescope Array (CTA) observing in synergy with the third generation of gravitational-wave detectors, such as the Einstein Telescope (ET) and Cosmic Explorer (CE). In particular, we evaluate the expected capabilities to detect and localize gravitational-wave events in the inspiral phase and to provide an early warning alert able to drive the VHE search. We compute the amount of possible joint detections by considering several observational strategies, and demonstrate that the sensitivity of CTA make the detection of the VHE emission possible even if it is several orders fainter than that observed at 10 keV–10 MeV. We discuss the results in terms of possible scenarios of the production of VHE photons from binary neutron star mergers.
Reeling in the Whirlpool galaxy: Distance to M 51 clarified through Cepheids and the type IIP supernova 2005cs
Authors: Csörnyei G. , Anderson R. I. , Vogl C. , Taubenberger S. , Blondin S. , Leibundgut B. , Hillebrandt W.
Published: August 2023

Context. The distance to the Whirlpool galaxy, M 51, is still debated, even though the galaxy has been studied in great detail. Current estimates range from 6.02 to 9.09 Mpc, and different methods yield discrepant results. No Cepheid distance has been published for M 51 to date.

Aims. We aim to estimate a more reliable distance to M 51 through two independent methods: Cepheid variables and their period-luminosity relation, and an augmented version of the expanding photosphere method (EPM) on the type IIP supernova SN 2005cs, which exploded in this galaxy.

Methods. For the Cepheid variables, we analysed a recently published Hubble Space Telescope catalogue of stars in M 51. By applying filtering based on the light curve and colour-magnitude diagram, we selected a high-quality sample of M 51 Cepheids to estimate the distance through the period-luminosity relation. For SN 2005cs, an emulator-based spectral fitting technique was applied, which allows for the fast and reliable estimation of the physical parameters of the supernova atmosphere. We augmented the established framework of EPM with these spectral models to obtain a precise distance to M 51.

Results. The two resulting distance estimates are DCep = 7.59 ± 0.30 Mpc and D2005cs = 7.34 ± 0.39 Mpc using the Cepheid period-luminosity relation and the spectral modelling of SN 2005cs, respectively. This is the first published Cepheid distance for this galaxy. The obtained values are precise to 4–5% and are fully consistent within 1σ uncertainties. Because these two estimates are completely independent, they can be combined for an even more precise estimate, which yields DM 51 = 7.50 ± 0.24 Mpc (3.2% uncertainty).

Conclusions. Our distance estimates agree with most of the results obtained previously for M 51, but they are more precise than the earlier counterparts. However, they are significantly lower than the TRGB estimates, which are often adopted for the distance to this galaxy. The results highlight the importance of direct cross-checks between independent distance estimates so that systematic uncertainties can be quantified. Because of the large discrepancy, this finding can also affect distance-sensitive studies and their discussion for objects within M 51, as well as the estimation of the Hubble constant through the type IIP standardizable candle method, for which SN 2005cs is a calibrator object.
Control of braking energy recovery of lifting machines
Authors: Barbashov Nikolay , Samoylova Marina , Polyantseva Anastasia
Published: August 2023

The increase in the energy consumption of machines when operating in unsteady modes is caused by many reasons, the main of which are deviation from the calculated operating modes and braking of the machine with irretrievable energy losses. When driving cars from electric motors, the recovery of braking energy can be carried out by switching them to the electric generator mode and returning the braking energy to the general power supply network. However, the absence of parallel consumers in the general power supply network requires the presence of an electric energy accumulator to recover braking energy. Effective recovery of braking energy can be carried out in a flywheel energy storage device with a high service life and high specific indicators of stored energy per unit weight of the storage device using differential gear mechanisms having two degrees of freedom.
Vertical motion robot in the mining industry
Authors: Sadkovskaya Nataliya , Kartsan Igor , Zhukov Aleksandr , Tarasov Vladimir , Kanygin Andrey , Kovalenko Mikhail , Maintsev Semyon
Published: August 2023

The main directions in the design and programming of vertical motion robots for the mining industry have certain operational risks that underlie the reasons for the lack of consideration of all possible scenarios. The main problem of vertical motion robots is the identification of specific situations. The problem of identification of specific situations occurring during the operation of a vertical motion robot is considered. Some critical situations are proposed for consideration, the forces acting on the robot nodes are illustrated. A model of the robot in MATLAB Simulink environment is created and programmed in order to study the current indicators in the electric motors of the robot. The submodel of the electric motor, based on the data of the technical data sheet of the existing product, which behaves reliably under the conditions of the simulation, is described. The simulation of one of the critical scenarios is considered, and the motor current indicators are analyzed.
Agent modeling of the distributed dynamic systems on the earth’s surface with using the colored and nested Petri nets
Authors: Dorrer Georgy
Published: August 2023

The application of formalisms of multi-agent systems, color and nested Petri nets to digital modeling and control of dynamic processes on the Earth’s surface is considered. A GIS-based multi-agent system has been implemented in the form of a two-level color nested Petri net. The system is currently accepted for use as a training simulator.
Application of digital twin technologies in mining industrial branch
Authors: Yusupbekov Nodirbek , Adilov Farukh , Ivanyan Arsen , Abdurasulov Fakhritdin
Published: August 2023

Digital Twin technology became one of most popular and modern information technologies and at the same time operation technologies in the roadmap of increasing effectiveness and performance of industrial enterprise. This is already solid trend in many different scaled industrial facilities which belong to different industrial branches. This paper has objective to present how digital twin technology can help in optimization and effectiveness increase for mining industry. We will try to review the whole process and show advantages of digital twin technology implementation in dedicated sector or stage of mining and mineral beneficiation processes such as mine planning, mine operations, rom processing, ore processing, concentrate stockpiles managing, concentrate transportation and concentrate processing facilities such as refineries or smelting plants.
Effect of dispersed particles of aluminum oxide on the degree of defects of the crystalline structure of the chromium coating
Authors: Mardonov Bakhtiyor , Oripov Zayniddin , Muminov Rashid , Ravshanov Jamshed , Jo’rayev Nodirbek
Published: August 2023

The paper investigated dependence of the defect of the chromic coating crystal structure containing aluminium oxide microsarches on the current density. The results are presented in graphical form. Likewise, a test of the bonding strength of the coating with the base metal has been carried out. The experiment was carried out by bending a flat sample with a test coating, and the conclusions of the tests are provided.
Force parameters of roller machines
Authors: Khurramov Shavkat , Kurbanova Feruza
Published: August 2023

To facilitate the force analysis of the roller machine under consideration, the previously obtained model of the pattern of distribution of normal contact forces is approximated by an empirical dependence. The moduli of the main vector of elementary normal and tangential forces of each roll, the main moments of elementary forces relative to the axis of each roll are determined. It is revealed that the qualitative distribution pattern of normal contact forces gives the magnitude of forces and moments, expressed through the maximum of the normal force.
Patientenlagerung im OP: Grundlagen und Best Practice
Authors: Ninow Beate , Staudacher Diana , Meier Bernadette
Published: August 2023

Chirurgische Patient*innen können sich aufgrund der Narkose nicht selbst bemerkbar machen, wenn Schmerzen oder Komplikationen durch die Lagerung entstehen. Deshalb müssen OP-Fachpersonen stellvertretend für den sedierten Menschen handeln, um lagerungsbedingte Verletzungen zu vermeiden. Welche Strategien sollten OP-Fachpersonen kennen? Und welchen Beitrag kann ein perioperatives Qualitätsmonitoring leisten?
Notfälle in der Medikamentösen Tumortherapie
Authors: Handke Analena , Hilser Thomas , Bögemann Martin , Schlack Katrin , Grünwald Viktor
Published: August 2023

Hintergrund Immunmodulatorische Therapien gewinnen immer größere Bedeutung in der Uro-Onkologie. Aus diesem Grund werden wir vermutlich immer häufiger mit Nebenwirkungen konfrontiert werden. Hinzu kommt eine immer größere Zahl an Kombinationen mit anderen Wirkmechanismen. Als Folge dieser Therapie können immun-vermittelte Nebenwirkungen auftreten. Diese unterscheiden sich von den Nebenwirkungen einer Chemotherapie und anderen zielgerichteten Therapien und erfordern daher andere Behandlungsstrategien.

Ziel der Arbeit Anhand der aktuellen Literatur werden die Daten zur Graduierung und stadienabhängigen Management dargelegt sowie mit Beispielen aus der Praxis anschaulich dargestellt.

Material und Methoden Literaturrecherche zur Detektion und Therapiemanagement von im Rahmen der immunonkologischen Therapie vermittelten Nebenwirkungen.

Ergebnisse Die behandlungsbezogenen Ereignisse können prinzipiell alle Organsystem betreffen, häufig sehen finden sich Toxizitäten im Bereich der Haut, wie Ausschlag oder Pruritus, Hypo- oder Hyperthyreosen, Arthritiden, Muskelschmerzen und gastrointestinale Symptome. In der Häufigkeit sind die meisten Nebenwirkungen Grad 1 bis 2 zuzuordnen, jedoch auch Grad 3 bis 4 Toxizitäten sind grundsätzlich gut zu therapieren, sofern sie frühzeitig erkannt werden. Seltene Komplikationen wie neurologische Toxizitäten, Pneumonitis oder auch Karditis können bei zu später Diagnose einen fulminanten Verlauf entwickeln.

Diskussion Selbst Notfälle sind gut zu managen, wenn wir die wichtigsten Nebenwirkungen und therapeutischen Optionen kennen. Dabei kommt den immunvermittelten Nebenwirkungen ein besonderer Stellenwert zu, weil sie grundsätzlich jedes Organsystem betreffen können. So lange wir jedoch bei Patienten, die Symptome zeigen, an die Möglichkeit einer Toxizität durch Checkpointinhibitoren denken, sind die meisten Nebenwirkungen gut zu therapieren und daher kontrollierbar.
Development of Weight and Height Age z-Score after Total Cavopulmonary Connection
Authors: Bilic Carlo , Staehler Helena , Niedermaier Carolin , Schaeffer Thibault , Cuman Magdalena , Heinisch Paul Philipp , Burri Melchior , Piber Nicole , Hager Alfred , Ewert Peter , Hörer Jürgen , Ono Masamichi
Published: August 2023

Objective We aimed to analyze somatic growth of patients after total cavopulmonary connection (TCPC) as well as to identify factors influencing postoperative catch-up growth.

Methods A total of 309 patients undergoing TCPC at 4 years old or less between 1994 and 2021 were included. Weight for age z-score (WAZ) and height for age-z-score (HAZ) at TCPC and at postoperative time between 1 and 3 years were calculated. Factors influencing somatic growth were analyzed.

Results Most frequent diagnosis and initial palliation were hypoplastic left heart syndrome (HLHS) (34%) and the Norwood procedure (51%), respectively. Median age and weight at TCPC were 2.0 (IQR: 1.7–2.5) years and 11.3 (10.5–12.7) kg, respectively. Median 519 days after TCPC, a significant increase in WAZ (−0.4 to −0.2, p < 0.001) was observed, but not in HAZ (−0.6 to −0.6, p = 0.38). Older age at TCPC (p < 0.001, odds ratio [OR]: 2.6) and HLHS (p = 0.007, OR: 2.2) were risks for low WAZ after TCPC. Older age at TCPC (p = 0.009, OR: 1.9) and previous Norwood procedure (p = 0.021, OR: 2.0) were risks for low HAZ after TCPC. Previous bidirectional cavopulmonary shunt (BCPS) was a protective factor for both WAZ (p = 0.012, OR: 0.06) and HAZ (p = 0.028, OR: 0.30) at TCPC.

Conclusion In patients undergoing TCPC at the age of 4 years or less, a significant catch-up growth was observed in WAZ after TCPC, but not in HAZ. Previous BCPS resulted to be a protective factor for a better somatic development at TCPC. HLHSs undergoing Norwood were considered as risks for somatic development after TCPC.
Resistance Training Intensity Prescription Methods Based on Lifting
Velocity Monitoring
Authors: Ramos Amador García
Published: August 2023

Resistance training intensity is commonly quantified as the load lifted relative
to an individual's maximal dynamic strength. This approach, known as
percent-based training, necessitates evaluating the one-repetition maximum (1RM)
for the core exercises incorporated in a resistance training program. However, a
major limitation of rigid percent-based training lies in the demanding nature of
directly testing the 1RM from technical, physical, and psychological
perspectives. A potential solution that has gained popularity in the last two
decades to facilitate the implementation of percent-based training involves the
estimation of the 1RM by recording the lifting velocity against submaximal
loads. This review examines the three main methods for prescribing relative
loads (%1RM) based on lifting velocity monitoring: (i) velocity zones,
(ii) generalized load-velocity relationships, and (iii) individualized
load-velocity relationships. The article concludes by discussing a number of
factors that should be considered for simplifying the testing procedures while
maintaining the accuracy of individualized L-V relationships to predict the 1RM
and establish the resultant individualized %1RM-velocity relationship:
(i) exercise selection, (ii) type of velocity variable, (iii) regression model,
(iv) number of loads, (v) location of experimental points on the load-velocity
relationship, (vi) minimal velocity threshold, (vii) provision of velocity
feedback, and (viii) velocity monitoring device.
Timing of Elective Cesarean Section and Neonatal Outcomes in Term Singleton Deliveries: A Single-Center Experience
Authors: Takahashi Daijiro , Fujino Yoshihisa , Sato Tomoki , Kuramoto Akitaka , Kawakami Shoichi , Ito Masaharu , Goto Kei
Published: August 2023

Objective This study aimed to evaluate the timing of elective cesarean sections at 37 to 41 weeks from a tertiary hospital in Japan. The primary outcome was the rate of adverse neonatal outcomes, especially focusing on neonates delivered at 38 weeks of gestation.

Study Design The study population was drawn from singleton pregnancies delivered following planned cesarean birth at the Fukuda Hospital from 2012 to 2019. Information on deliveries was obtained from the hospital database, which contains clinical, administrative, laboratory, and operating room databases.

Results After excluding women with chronic conditions, maternal complications, indications for multiple births, or a neonate with an anomaly, 2,208 neonates remained in the analysis. Among adverse neonatal outcomes, the rate was significantly higher in neonates delivered at 37 weeks of gestation (unadjusted odds ratio [OR] = 13.22 [95% confidence interval [CI]: 6.28, 27.86], p < 0.001) or 38 weeks of gestation (unadjusted OR = 1.82 [95% CI: 1.04, 3.19], p = 0.036) compared with neonates delivered at 39 to 41 weeks. The adjusted risk of any adverse outcome was significantly higher at 380–1/7 weeks (adjusted OR = 2.40 [95% CI: 1.35, 4.30], p = 0.003) and 382–3/7 weeks (adjusted OR = 1.89 [95% CI: 1.04, 3.44], p = 0.038) compared with neonates delivered at 39 to 41 weeks, respectively.

Conclusion Our findings suggest that elective cesarean sections might be best scheduled at 39 weeks or later. When considering a cesarean at 38 weeks, it appears that 384/7 weeks of gestation or later could be a preferable timing in the context of reducing neonatal risks. However, as the composite outcome includes mostly minor conditions, the clinical significance of this finding needs to be carefully interpreted.

Key Points
Decreasing Antibiotic Use in a Community Neonatal Intensive Care Unit: A Quality Improvement Initiative
Authors: Singh Harjinder P. , Wilkinson Susan , Kamran Shahid
Published: August 2023

Objective In view of the excessive use of antibiotics in our neonatal intensive care unit (NICU), we launched a 5-year multidisciplinary quality improvement (QI) initiative in our NICU in 2018. We had set our aim of decreasing the antibiotic use rate (AUR) from 22 to 17%.

Study Design The QI initiative was conducted in our 53-bed level 3B NICU. We used the core elements of antibiotic stewardship and focused on improving gaps in knowledge by using updated standards of care and a multidisciplinary approach. Outcome measures included overall AUR in NICU. Statistical control chart (P chart) was used to plot the AUR data quarterly.

Results The AUR demonstrated a decline at the onset, and at the end of the initiative the AUR demonstrated a sustained decline to 13.18%, a 40% decrease from the baseline AUR of 22%. The changes that were implemented included development of evidence-based guidelines for babies less than and greater than 35 weeks, daily antibiotic stewardship rounds, sepsis risk calculator, antibiotic stop orders (48-hour stop, 36-hour soft stop, and 36-hour hard stop), and periodic reviews.

Conclusion Our multidisciplinary approach using all the core elements of an antibiotic stewardship program significantly decreased AUR in our NICU.

Key Points
Gastrointestinal Dysfunction in Neurological and Neurodegenerative Disorders
Authors: Raber Jacob , Sharpton Thomas J.
Published: August 2023

Increasing research links the gut microbiome to neurodegenerative disorders. The gut microbiome communicates with the central nervous system via the gut–brain axis and affects behavioral and cognitive phenotypes. Dysbiosis (a dysfunctional microbiome) drives increased intestinal permeability and inflammation that can negatively affect the brain via the gut–brain axis. Healthier metabolic and lipid profiles and cognitive phenotypes are observed in individuals with more distinct microbiomes. In this review, we discuss the role of the gut microbiome and gut–brain axis in neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease and related animal models, in cancer and cancer treatments, and in metabolic syndrome. We also discuss strategies to improve the gut microbiome and ultimately brain function. Because healthier cognitive phenotypes are observed in individuals with more distinct microbiomes, increased efforts are warranted to develop therapeutic strategies for those at increased risk of developing neurological disorders and patients diagnosed with those disorders.
Decreased Cognitive Function in Danish Children with Epilepsy
Authors: Bogut Laura , Andersen Kaja , Grejsen Judy , Gimenez-Rico Maria Jose Miranda , Debes Nanette Monique Mol
Published: August 2023

Objective Children with epilepsy have a significantly increased risk of cognitive impairment. EpiTrack Junior is a screening tool developed for fast assessment of cognitive function in children with epilepsy. The tool is validated for German children. This cohort study aims to investigate the differences in cognitive function between healthy Danish children and Danish children diagnosed with epilepsy

Methods The cognitive function of 204 healthy controls and 90 children and adolescents diagnosed with epilepsy was examined using EpiTrack Junior. The participants of the control group were aged 6 to 16 years. The patients were aged 6 to 20 years. Statistical analyses were performed with the use of SPSS Statistics.

Results The control group showed significantly higher scores than the patient group in three of six subtests and total test scores (p-values ranging from 0.033 to <0.001). When grouped according to the EpiTrack Junior guidelines, more patients showed scores “below average” or “poor” compared to the control group. The age-corrected total score was not associated with antiepileptic drug treatment (p-value of 0.732) nor with a history of focal seizures (p-value of 0.215). A history of generalized tonic–clonic seizures (GTCS) was associated with a higher EpiTrack Junior score (p-value of 0.035).

Conclusion The patient group showed statistically significant lower test scores compared to the control group confirming the relationship between impaired cognitive function and childhood epilepsy. Furthermore, a correlation between a higher EpiTrack Junior score and the presence of GTCS was found. Focal seizures and antiepileptic drug treatment were not associated with the EpiTrack Junior score.
Forged facial video detection framework based on multi-region temporal relationship feature
Authors: Fang Xing , Hao YanNi , Luo Yin , Xu Nan , Cao Jia
Published: August 2023

Face generation and manipulation techniques based on deep learning have enabled the creation of sophisticated forged facial videos, which are indistinguishable by human eyes. However, the illegal use of deep fake technology will have a serious impact on social stability, personal reputation, and even national security. Therefore, the detection technology of fake facial videos is of great significance to protect national security and maintain social order. Although the existing video-based fake face video detection technology has achieved good detection performance on the public fake face video database, there are still the following problems: (1) the existing technology uses a 2D attention mechanism to obtain local region features from face images and lacks a 3D attention mechanism to obtain local area features from face videos; (2) after obtaining local area features, the existing technology is directly used to classify or only model the inter-regional relationship of images without modeling the temporal relationship between regions of the video. This paper proposes a fake facial video detection framework based on multi-region temporal relationship features, including designing a three-dimensional attention mechanism to extract local features of multiple regions of the face from the video. In order to model the time series relationship between different face areas, a time series graph convolution neural network is also introduced to extract the time series relationship features between multiple areas. In order to model the time sequence relationship between different face regions, the convolution neural network of a time sequence diagram is also introduced to extract the characteristics of the time sequence relationship between multiple regions. Through the change characteristics of the time sequence relationship between face regions, the timing inconsistency of the face video is detected so as to determine whether the face has been deeply forged. Through experiments on multiple datasets, the experimental results of the model accuracy test show that the method proposed in the present invention achieves the highest detection accuracy, and the accuracy in the FaceForensics++ (low definition) dataset is 18.19% higher than that of the benchmark method. The experimental results of the generalization ability test show that the method proposed in the present invention achieves the highest generalization performance, and the detection accuracy in the Celeb-DF dataset is 11.92% higher than that of the benchmark method.
Toward a classification of conformal hypersurface invariants
Authors: Blitz Samuel
Published: August 2023

Hypersurfaces embedded in conformal manifolds appear frequently as boundary data in boundary-value problems in cosmology and string theory. Viewed as the non-null conformal infinity of a spacetime, we consider hypersurfaces embedded in a Riemannian (or Lorentzian) conformal manifold. We construct a finite and minimal family of hypersurface tensors—the curvatures intrinsic to the hypersurface and the so-called “conformal fundamental forms”—that can be used to construct natural conformal invariants of the hypersurface embedding up to a fixed order in hypersurface-orthogonal derivatives of the bulk metric. We thus show that these conformal fundamental forms capture the extrinsic embedding data of a conformal infinity in a spacetime.
Finesse of ring resonators
Authors: Yang Quankui
Published: August 2023

We deduce in this paper the exact solutions for the calculation of full width at half maximum (FWHM) and finesse F of ring resonators in which light is coupled from a bus to a ring. These solutions are shown to be simple in math. Furthermore, we deduce the electric field relationships for the case if light is generated within the ring and out-coupled to the bus and obtain the expression for the calculations of FWHM and finesse for this configuration. Our method is shown to produce more accurate results than those with the widely used approximation method, in particular, if the ring resonator works in low quality-factor regime.