bluuebunny/crossref_metadata_2025 huggingface dataset:
Edad y actitudes hacia la homosexualidad: el futuro de los derechos de la comunidad LGBTI+ en Paraguay
Authors: Codas Gerónimo
Published: July 2022

En los últimos años, distintos países han modificado partes de su legislación en favor de los derechos de la comunidad LGBTI+. Estas modificaciones se vieron influidas por cambios en las actitudes de la población hacia esta comunidad, que responden a un recambio generacional donde los jóvenes muestran menos prejuicios hacia orientaciones no heterosexuales. El presente estudio pretende elucidar si en la situación actual en Paraguay se desarrolla un fenómeno similar. Participaron 801 habitantes de la capital y el interior de la República del Paraguay, de entre 13 y 77 años de edad (M = 27.33; DE = 10.03). Contestaron una encuesta acerca de su opinión sobre la legalización de la unión civil de parejas homosexuales, la cual funcionaría como indicador de actitudes hacia la homosexualidad. Se halló una relación baja significativa entre la edad y estas actitudes (rho = -.22; p = .000), además de diferencias significativas entre habitantes de la capital y del interior de Paraguay (p = .04), donde los últimos presentan actitudes más desfavorables.
UJI ANTIBAKTERI Ag/SBA-15 DARI ABU DAUN BAMBU PETUNG TERHADAP BAKTERI Escherichia coli
Authors: Nurdahniyati Nurdahniyati , Handayani Nunung , Subagyono RR Dirgarini Julia Nurlianti , Kusumawati Eko
Published: July 2022

Antibacterial tests of Ag/SBA-15 from petung bamboo leaf ash against Escherichia coli were carried out. Modification of SBA-15 with Ag was conducted using the wet impregnation method while the antibacterial test was carried out by well diffusion method and disc diffusion method with various concentrations of Ag/SBA-15. The Ag/SBA-15 has a surface area of ​​143 m2/g, pore diameter of 8.4 nm and pore volume of 0.35 cm3/g. The SAXS pattern of   Ag /SBA-15 showed 3 typical SBA-15 peaks in the 0o -2o 2θ range with the miller index [100], [110] and [200], indicating modification with Ag did not change the hexagonal structure of SBA-15. Ag / SBA-15 material has the potential as an antibacterial agent for Escherichia coli; the inhibitory zone diameters for the well diffusion method and disc diffusion method were 7.00 ± 0.57 mm and 13.16 ± 0.16 mm, respectively. Increasing the concentration of Ag/SBA-15 samples resulted in greater inhibitory zone diameters for the bacteria.
Validasi Metode Penentuang Minyak dan Lemak dalam air Laut dengan Spektrofotometri Inframerah
Authors: Samban Gaisandry Devira
Published: July 2022

Validation research method of determining oil and grease in sea water with Infrared Spectrophotometry has been conducted. To obtain valid measurement results, the research stages included measurements in the form of validation parameters such as linearity test, limit detection (LOD), quantization limit (LOQ), recovery, precision, reproducibility, detection limit of method (MDL), instrument validation and measurement uncertainty. The results showed that linearity met the good results with a correlation coefficient (R2) ≥ 0.995; LOD is 0.1 mg/L, LOQ is 0.5 mg/L, % recovery with a range of(104,59 ± 1,73)%; repetition and reproducibility was expressed as % SBR <% KV Horwitz, MDL is 0.2745 mg/L. Based on the results of this study, infrared spectrophotometry methods can be used in determining oil and fat in seawater samples with valid results.

 

Keywords: method validation, oil and greace, infrared spectrophotometry.
COVID-19 as Force Majeure in Insurance Agreement
Authors: Padmo Aditya , Joesoef Iwan Erar
Published: July 2022

Force majeure is an unexpected or unknown event which occur out of control that obstructs a party to fullfill the obligations in the agreement. This clause exempts the parties from the obligation to compensate either overall or partially for conducting default on contract. This research is normative legal research conducted by examining secondary, primary, and tertiary legal materials. As for research, conducted using conceptual approach and statute approach. The results show that COVID-19 is a relative force majeure. This condition affects the debtor’s economic ability to pay premiums to insurance companies every month. But according to article 1244 ICC the debtor must prove that the condition cannot be blamed on them. After it is proven article 1245 ICC can be applied which exempts the debtor from the obligation of compensation. In the face of COVID-19 as a force majeure insurance companies can implement an agreement restructuring policy in accordance with Financial Services Authority Regulations Number 14 of 2020. By implementing this policy insurance company can avoid the cancellation of the agreement due to force majeure.
Menelaah Koperasi Era Omnibus Law
Authors: Suryokumoro Herman , Hikmatul Ula
Published: July 2022

Gagasan modernisasi koperasi bukan hal baru, gagasan ini muncul seiring dengan tuntutan globalisasi ekonomi yang menuntut peran koperasi untuk dapat bersaing dalam pertarungan pasar bebas. Namun nampaknya, hingga saat ini pemerintah belum menemukan formula yang jitu untuk mendongkrak koperasi di Indonesia agar mampu bersaing. Modernisasi koperasi dapat dilakukan dengan mengacu para aspek-aspek dalam koperasi yaitu dalam hal kelembagaan, usaha, dan permodalan koperasi. Modernisasi usaha mutlak harus dibarengi dengan digitalisasi. Modernisasi koperasi tidak akan berhasil hanya dengan mempermudah izin pendirian dan izin usaha koperasi semata, dalam pada itu sinergitas antar element yang tekait dengan koperasi termasuk didalamnya quadruple helix (pemerintah, masyarakat, perguruan tinggi dan dunia usaha) harus turut menumbuhkan usaha usaha koperasi. Tantangan modernisasi koperasi ada pada pola hubungan koperasi dan pemerintah. Dalam era globalisasi bersaingan bebas fase hubungan koperasi dan pemerintah sudah tidak bisa lagi berada pada fase officialisasi tetapi sudah harus pada fase otonom. Kebijakan-kebijakan modernisasi era omnibus law harus didasarkan pada semangat menumbuhkan kesadaran berkoperasi dengan kualitas sember daya manusia yang mumpuni, semangat sinergitas usaha koperasi dengan entitas bisnis lainnya dan semangat otonomi koperasi dengan meminimalisasi unsur-unsur politik - kekuasaan dalam pengembangan koperasi.
Criminal Liability Of Misuse Personal Identity Number For Cellphone Cards Registration Illegally
Authors: Aziz Ubait Kurniawan , Azizah Hidayat Nur
Published: July 2022

Telecommunication network is a necessity needed today and ever after. This momentum is exploited by several cheaters who looking for big profits. The one of bad trick is misuse someone else's ID card to register cellphone SIM Card so it can be sells faster. And that’s actually against not only Law no. 24 of 2013 concerning Population Administration but also Law No. 19 of 2016 concerning Amendments to Law no. 11 of 2008 concerning Information and Electronic Transactions. The regulations about criminal liability misuse ID cards other person for registration cellphone SIM card not get serious attention from government. Therefore, the purposes of this research are : (1) using someone else's Personal Identity Number and Family Identity Number for cellphone SIM Cards registration illegally is an act of crime; (2) criminal liability of misuse other people's Personal Identity Number and Family Identity Number for registration cellphone SIM Cards based on the ITE Law and the Population Administration Law. This research using normative legal research, while methods using Statute Approach and Conceptual Approach. The results of this research found criminal liability sanctions for misuse someone else’s Personal Identity Number and Family Identity Number for registration cellphone SIM Cards illegally based on the ITE Law, the Criminal Code Law, and the Population Administration Law.
On Mechanical Response of Aluminum Alloys in Corrosive Environment
Authors:   Department of Mechanical Engineering, A J Institute of Engineering and Technology, Mangalore, Karnataka, 575006, INDIA, Kumar S Sunil , V Londe Neelakantha ,   Department of Mechanical Engineering, Mangalore Institute of Technology and Engineering, Moodabidri, Karnataka, 574225, INDIA, K Dilip Kumar ,   Department of Mechanical Engineering, Shree Devi Institute of Technology, Mangalore, Karnataka, 574142, INDIA, Kittur M. I. ,   Department of Mechanical Engineering, Faculty of Engineering,  University of Malaya, 50603 Kuala Lumpur, MALAYSIA, Badruddin Irfan Anjum ,   Department of Mechanical Engineering, College of Engineering,  King Khalid University, Abha 61421, SAUDI ARABIA, Faheem Mohammed ,   Department of Mechanical Engineering,  International Islamic University of Malaysia, 50728 Kuala Lumpur, MALAYSIA, Khan Sher Afghan ,   Department of Mechanical Engineering,  International Islamic University of Malaysia, 50728 Kuala Lumpur, MALAYSIA
Published: July 2022

Al6061T6 and Al7075T6 aluminum alloys are subjected to accelerated salt spray corrosion to evaluate the amount of degradation and the effect on mechanical behavior. The specimens were stored in a closed chamber with continuous salt spray for a period of 250 hours and 500 hours, respectively. It was observed that the oxide layer was unprotective after prolonged salt spray resulting in pitting continued with exfoliation corrosion. The tensile test results show that there was a remarkable decrease in tensile properties with exposure time. A significant reduction in tensile strength, yield strength, elongation at yield, elongation at break, and overall toughness in both the alloys was observed at 500 hours. The impact strength decreased by 14.4 % and 26.47 %, Rockwell hardness (HRB) reduced by 12.2% and 20.71% for respective alloys at 500 hours of exposure. However, there was an increasing trend in elastic stiffness which attributed to decrease in ductility. Furthermore, it was comparatively observed that Al7075T6 is more susceptible to corrosion than Al6061T6.
Preparation of Module 1 of the Registration Dossier According to the EAEU Procedure
Authors: Rychikhina E. M.
Published: July 2022

The legislation of the Eurasian Economic Union (EAEU) includes all the necessary requirements and tools to implement a unified approach to preparing Module 1 of the electronic Common Technical Document (eCTD) for the concerned member states (CMSs). However, the approaches to the matter and the recommendations provided to applicants differ across member states. This causes significant ambiguity and imposes an excessive burden on the applicants. Drafting of a guideline on preparation of eCTD Module 1 for the CMSs will allow for tackling this important grey area in the EAEU regulatory framework, as regulatory authorities are lacking consensus on country-specific submissions. Currently, pharmaceutical industry stakeholders consider the Russian experience of implementing the legislation in question the most successful, so it is proposed to convey this experience to the common market of the EAEU.
Data compatibility and portability for ensuring technical interoperability of network-centric systems
Authors:   St. Petersburg Federal research center of the Russian Academy of Sciences, 197376, Saint Petersburg, 14 linia V.O., 39, Makarenko S.I.
Published: July 2022

In the situation of transition from information and control systems to a net-centric architecture and development of net-centric system (NCS), the relevance of interoperability assurance in such systems is increasing. The study of ensuring data compatibility and portability in the implementation of technical interoperability of NCS, taking into account the data lifecycle, is carried out in the paper. Recommendations on ensuring compatibility and portability of data at the stages of formation, transmission, storage, processing and presentation of data in NCS are proposed in this paper.
Work overload and organisational climate as predictors of job burnout among primary school teachers in Lesotho
Authors:   Department of Educational Foundations, Faculty of Education, National University of Lesotho, Lesotho, Makhetha Isaiah
Published: July 2022

This investigation adopted a correlational research design. This study aimed to establish whether work overload and organisational climate are predictors of burnout among primary school teachers in Lesotho. The sample comprised 350 primary school teachers. Data were collected through the use of the Maslach Burnout Inventory-Educators Survey, Overload Scale and School Environmental Questionnaire. Multiple regression analysis reveals that work overload and organisational climate are predictors of burnout among teachers. Pertaining to work overload, the study finds that primary school teachers in Lesotho are burdened with teaching many grades. In relation to organisational climate, the findings of the study are that teachers work under unfavourable working conditions.
The effect of educational game activities applied on the academic achievement of secondary students in science education
Authors:   Department of Mathematics and Science Education, Education Faculty, Trakya University, Edirne, Turkey, Kiliç Ismail
Published: July 2022

The research aims to examine the effect of educational game activities on academic achievement in secondary school 5th-grade science lessons. The study group of the research consists of 71 5th-grade students studying at a public school in Turkiye in the 2017-2018 academic year. In the research, the pre-test and post-test comparative design group, which is one of the quantitative research methods, was used to achieve the research objectives. A random sampling technique was used to determine these two groups. In the experimental group (EG), the lessons were enriched with educational game activities (EGA). The control group (CG) taught the courses based on the current science teaching program (CSTP). An academic achievement test (AAT) has been prepared for the unit goals of the 5th-grade science course "Spreading of Light". AAT was applied to the groups before and after the experiment ındepended samples t-test and Whitney u-test were used in the analysis of the data. The data showed that the EGA used in the science course has a positive effect on academic achievement.
Religion and Politics: Symbolization of Religion in the contestation of legislative elections 2019
Authors: Sipa Amar Muhyi Dinis , Wadi Hopizal , Fahrurrazi Fahrurrazi
Published: July 2022

Politics and religion have become inseparable these days. Politicians or political parties' piety and religiosity have become a necessity. A Strong religion as a doctrine, even politics, requires religion as a tool of legitimacy to achieve existence, power and attract votes and sympathy from the masses. Finally, spirituality and religious symbols become political products and domains that become the identity of politicians and political parties and are then introduced to the public, known as political marketing. This article aims to understand further political discourse with religious symbolic packaging on PKS candidate posters used as campaign tools to influence public choice. The approach in this article uses semiotic analysis to analyze the symbols in the political campaign posters of candidates on social media. So, Semiotics tries to dismantle signs that have meaning in social life and political life. The method used in this article is a qualitative method that is descriptive-analytical, with a data collection technique analyzing campaign posters on Instagram social media on the @pkstangerang account. The result of this article is that religious politics exists because of the role of religion that can touch the emotional side of humans. In the account @pkstangerang, most of his posts are inseparable from religious spirituality and religious doctrine elements. While campaigning in legislative elections also can not be separated from religious symbols and narratives or symbols of piety, for example, candidates who wear peci, koko clothes, and hold the book of fiqh. For this reason, the term religious politics in politics or legislative elections is a religious campaign term that describes religiosity in politics as a way of political marketing.
Wilhelm Dilthey's Hermeneutical Methodology in Understanding Text
Authors: Nasution Umaruddin
Published: July 2022

The research aims to describe the methodology of hermeneutics Wilhelm Dilthey in understanding text. Dilthey was a philosopher who played an important role in developing hermeneutics as a scientific methodology. The study used library research which guides the hermeneutic books and other documents that give explanations of their thinking. This research also used a historical-philosophical approach and content analysis. The results of this study indicate that Dilthey thought of hermeneutics has three formulations in which the text’s interpretation is experience, expression, and understanding. Dilthey's hermeneutics methodology is a process of interpreting text by understanding the author's history, which manifests into a text, language, and discourse.
Keterwakilan Perempuan dalam Parlemen: Studi Analisis Peran Publik Perempuan dalam DPRD Kota Manado (Women's Representation in the Parliament: An Analytical Study of Women's Public Role in the House of Representatives of the City of Manado)
Authors: Alfiyani Nur
Published: July 2022

Rendahnya pengetahuan perempuan tentang politik serta masih kurangnya dukungan partai politik menyebabkan perempuan lemah di bidang perpolitikan. Berdasarkan hal tersebut pemerintah kemudian menerapkan peraturan UU Pemilu dan Partai Politik yang mengatur mengenai 30% keterwakilan perempuan agar perempuan dapat ikut terlibat aktif dalam menghasilkan kebijakan. Penelitian ini bertujuan untuk menganalisis pengimplementasian kuota 30% anggota legislative di DPRD Kota Manado periode 2014-2019 terhadap masyarakat perempuan. Fokus penelitian ini adalah bagaimana kuota 30% yang diwakili oleh anggota legislatif perempuan mengambil peran dan tanggung jawab dalam menghasilkan perda-perda yang berpihak kepada perempuan. Penelitian ini menggunakan metode penelitian kualitatif dengan melakukan pengumpulan data melalui teknik in-depth interview. Hasil penelitian menunjukkan bahwa sebanyak 32.5% anggota legislatif perempuan terpilih pada periode 2014-2019 namun peningkatan persentasi jumlah keterwakilan perempuan di DPRD Kota Manado tersebut dianggap masih belum mampu mewakili kepentingan masyarakat perempuan. Ketidakmampuan ini terlihat pada kurangnya peran anggota legislatif perempuan dalam menjalankan fungsi legislasi seperti: pembuatan perda inisiatif yang masih saja ditentukan berdasarkan skala prioritas. Hal ini memperlihatkan bahwa keterwakilan 30% yang telah diupayakan oleh pemerintah terlihat masih belum maksimal dari segi kualitas. Penelitian ini menyimpulkan bahwa dibutuhkan peningkatan kemampuan anggota legislative perempuan dari segi integritas, kapasitas serta kapabilitas sehingga bentuk partisipasi aktif tersebut dapat menghasilkan kebijakan di tingkat lokal yang mewakili kepentingan masyarakat perempuan.
Pemberitaan Muktamar NU Ke-34 di Lampung: Analisis Wacana di Media Online Jawa Post (The Announcement of the 34th NU Conference in Lampung: A Discourse Analysis on the Jawa Pos Online Media)
Authors: Hasan Moh. Fuad , Lestari Sri
Published: July 2022

Muktamar NU ke-34 yang di selenggarakan pada bulan Desember tahun 2021 lalu menjadi perhatian orang banyak, tidak sekedar dari kalangan NU semata, melainkan warga Negara Indonesia. Proses muktamar selama berlangsung terdapat dinamika yang terjadi di antara kubu pengusung Gus Yahya dan Kiai Said cukup panas. Satu sama lain saling melempar statement mengunggulkan pilihannya dan mengkritik lawannya. Untuk itu, penulis tertarik untuk melakukan kajian pada pemberitaan yang dimuat oleh Harian Jawa Pos mengenai Muktamar NU ke 34. Bagaimana berita tersebut disajikan menjadi sebuah teks media. Wacana yang dikembangkan oleh media Jawa Pos dalam memberitakan muktamar NU ke-34. Artikel ini bertujuan mengungkap wacana yang dikembangkan media Jawa Post dalam pemberitaan muktamar NU ke 34 di Lampung di dalam praktik berdemokrasi. Metode penelitian yang digunakan adalah metode kualitatif diskriptif analitik. Pendekatan yang digunakan adalah analisis wacana, dengan menghimpun berita yang terkait dengan Muktamar NU ke-34 kemudian melakukan seleksi sesuai dengan tema yang penulis anggap relevan dengan artikel ini. Dalam kajian ini menemukan bahwa dalam pemberitaan yang dilakukan oleh Jawa Pos terdapat relasi yang kuat. Porsi pemberitaan muktamar NU ke-34 Jawa Pos memiliki kecenderungan mendukung setiap ide, kebijakan, dan langkah yang diambil oleh pemerintah sehingga tema-tema pemberitaannya juga cenderung nasionalis. Bahwa Jawa Pos yang dalam hal ini diwakili oleh wartawan telah mengidentifikasi dirinya sebagai bagian dari NU. Dalam melakukan pemberitaan mengenai Muktamar NU, wartawan cenderung memunculkan tema-tema baik dan dengan menggunakan kata-kata berkonotasi positif. Proses mukta ar dalam pemilihan ketua umum dalam berdemokrasi menjadi panutan generasi selanjutnya.
Optimalisasi Motivasi dan Hasil Belajar Peserta Didik Mata Pelajaran Ekonomi KD 3.6/4.6 Materi Bank Sentral, Sistem Pembayaran dan Alat Pembayaran dalam Perekonomian Indonesia Melalui Model Projects Based Learning Metode Pemberian Tugas di Kelas X.IPS.3 M
Authors: Wirda Rasna
Published: July 2022

This study aims to see and analyze the increase in motivation and learning outcomes of students in economic subjects with the material Central Bank, Payment Systems and Payment Instruments in the Indonesian Economy with the Projects Based Learning Model Giving Assignment Method in Class X.IPS.3 MAN 2 Payakumbuh Even Semester 2021/2022 Academic Years. This research consists of two cycles, where each cycle consists of; planning, action, reflection, and evaluation. It was carried out from January to April 2022. The data was processed in each cycle and then analyzed using percentages. The results obtained from this study are the Project based learning model, the assignment method can increase students' motivation and learning outcomes. This is evidenced by an increase in student motivation in cycle I and cycle II, the results obtained for motivation are 80.75% while in cycle II it is 92.85%. The increase in the average value of learning outcomes for knowledge competence in Cycle I was from 80.56 to 90.00 in Cycle II and learning outcomes for skill competencies increased from 86.39 in Cycle I to 91.53 in Cycle II. Students' learning mastery for knowledge in the first cycle which was completed was 30 people (83.33%) and for skills 30 people were also completed (83.33%) while in the second cycle the results were obtained for knowledge of 34 people who were complete (94.44%) while for the skills of 35 people who have completed (97.22 %). The conclusion obtained from this research is that the use of the Project based learning model of the assignment method can increase students' motivation and learning outcomes.
Meningkatkan Kemampuan Motorik Halus Anak Usia Dini Melalui Kegiatan Meronce di Taman Kanak-kanak Nusa Indah Kota Payakumbuh
Authors: Fithria Linda
Published: July 2022

This study aims to determine how the implementation of meronce activities to improve the fine motor skills of early childhood in Nusa Indah Kindergarten, Kec. Payakumbuh Utara Payakumbuh City in the 2022-2023 school year. The type of research used is Classroom Action Research (CAR) which was conducted in two cycles. The subjects of this study were group B students of Nusa Indah Kindergarten in the academic year 2022-2023 with 4 boys and 5 girls, so there were 10 children. The method used in this research is through the assignment of activities in meronce. The data from the research results obtained were then analyzed in order to draw conclusions. The results of the research that the author did show that the increase in children's fine motor skills through meronce activities in the first cycle reached 30% and after the second cycle there was a significant increase, where the children's fine motor achievement became 90%. The implication of this research is that the application of the assignment method through meronce activities can improve the fine motor skills of children in Nusa Indah Kindergarten, Kec. North Payakumbuh Payakumbuh City.
Temperature-control systems’ review of lithium-ion cells for battery
Authors:   LLC «Liteko», Moscow, 117312, Russian Federation, Alekov S. F. , Golubchik T. V. ,   Moscow Automobile and Road Construction State Technical University (MADI), Moscow, 125319, Russian Federation
Published: July 2022

Excessive heat may be a cause of a battery failure. Thermal runaway is a common failure mode that can occur in all types of electrochemical batteries. This can be especially dangerous for lithium-ion cells due to their high energy density and flammability. So, it is necessary to strictly control the temperature of the battery to avoid thermal runaway and improve the reliability and durability of the battery. The temperature control only by taking into account the average battery temperature can damage the entire battery pack. The existing systems for monitoring the temperature of cells in a storage battery have been examined.
Benefits and Risks in Polypathology and Polypharmacotherapy Challenges in the Era of the Transition of Thalassaemia from a Fatal to a Chronic or Curable Disease
Authors: Kolnagou Annita , Kleanthous Marios , Kontoghiorghes George J.
Published: July 2022

Beta thalassaemia major (TM), a potentially fatal haemoglobinopathy, has transformed from a fatal to a chronic disease in the last 30 years following the introduction of effective, personalised iron chelation protocols, in particular the use of oral deferiprone, which is most effective in the removal of excess iron from the heart. This transition in TM has been achieved by the accessibility to combination therapy with the other chelating drugs deferoxamine and deferasirox but also therapeutic advances in the treatment of related co-morbidities. The transition and design of effective personalised chelation protocols was facilitated by the development of new non-invasive diagnostic techniques for monitoring iron removal such as MRI T2*. Despite this progress, the transition in TM is mainly observed in developed countries, but not globally. Similarly, potential cures of TM with haemopoietic stem cell transplantation and gene therapy are available to selected TM patients but potentially carry high risk of toxicity. A global strategy is required for the transition efforts to become available for all TM patients worldwide. The same strategy could also benefit many other categories of transfusional iron loaded patients including other thalassaemias, sickle cell anaemia, myelodysplasia and leukaemia patients.
IL-2 and Zoledronic Acid Therapy Restores the In Vivo Anti-Leukemic Activity of Human Lymphocytes Pre-Exposed to Simulated Microgravity
Authors: Mylabathula Preteesh L. , Diak Douglass M. , Baker Forrest L. , Niemiro Grace M. , Markofski Melissa M. , Crucian Brian E. , Katsanis Emmanuel , Simpson Richard J.
Published: July 2022

Background: We have previously shown that the anti-tumor activity of human lymphocytes is diminished in vitro after 12-hours pre-exposure to simulated microgravity (SMG). Here we used an immunocompromised mouse model to determine if this loss of function would extend in vivo, and to also test the efficacy of IL-2 and zoledronic acid (ZOL) therapy as a potential countermeasure against SMG-induced immune dysfunction. We adoptively transferred human lymphocytes that were exposed to either SMG or 1G-control into NSG-Tg (Hu-IL15) mice 1-week after they were injected with a luciferase-tagged human chronic myeloid leukemia (K562) cell line. Tumor growth was monitored 2x weekly with bioluminescence imaging (BLI) for up to 6-weeks. Results: Mice that received lymphocytes exposed to SMG showed greater tumor burden compared to those receiving lymphocytes exposed to 1G (week 6 BLI: 1.8e10 ± 8.07e9 versus 2.22e8 ± 1.39e8 photons/second; p < 0.0001). Peak BLI was also higher in the SMG group compared to 1G-control (2.34e10 ± 1.23e10 versus 3.75e8 ± 1.56e8 photons/second; p = 0.0062). Exposure to SMG did not affect the ability of human lymphocytes to engraft or evoke xeno-graft-versus-host disease in the mice. Additionally, we injected the mice with IL-2 and zoledronic acid (ZOL) to expand and activate the anti-tumor activity of NK cells and γ δ-T cells, respectively. This treatment was found to revive the loss of anti-leukemic function observed in vivo when lymphocytes were pre-exposed to SMG. Conclusions: Microgravity plays a contributory role in loss of tumor control in vivo. Immuno-stimulating agents like ZOL+IL-2 may offer an important countermeasure for immune dysregulation during prolonged spaceflight.
ALISIS DAMPAK DAN KINERJA PROGRAM PENUGASAN KHUSUS EKSPOR (NATIONAL INTEREST ACCOUNT) INDUSTRI KA PADA PEREKONOMIAN INDONESIA
Authors: Yulianto Ivan , Budiarso Rahmad , Subiyantoro Heru
Published: July 2022

Penelitian ini bertujuan untuk mengetahui dampak program Penugasan Khusus Ekspor (PKE) Industri Kereta Api terhadap perekonomian Indonesia dengan menghitung besar nilai keterkaitan sektor tersebut dengan sektor yang lain dan efek multiplier sektor ekonomi tersebut terhadap produksi output, pendapatan, dan tenaga kerja. Penelitian ini menggunakan metode analisis input-output yang meliputi analisis derajat kepekaan, indeks daya penyebaran dan analisis keterkaitan antar sektor, dan menghitung efek multipliernya. Tabel input-output Indonesia yang digunakan dalam penelitian ini adalah tabel Tahun 2016 yang diklasifikasikan menjadi 14 sektor perekonomian. Hasil dari penelitian ini menunjukkan sektor industri kereta api memberikan pengaruh positif dalam peningkatan output sektor lain yang menjadi input bagi sektor industri kereta api. Industri pengolahan, pertanian, kehutanan, perikanan, transportasi pergudangan, serta pertambangan dan penggalian merupakan sektor yang paling terpengaruh dengan adanya peningkatan output sektor industri kereta api.

 

Kata kunci: Analisis Input Output, Efek Multiplier, Industri Kereta Api, Keterkaitan Antar sektor, Penugasan Khusus Ekspor.
KAJIAN EKSTENSIFIKASI CUKAI JASA TELEKOMUNIKASI
Authors: Lorosae E. J. Ratih , Setyawan Budhi
Published: July 2022

Perkembangan teknologi komunikasi yang pesat menimbulkan peluang bagi penyedia layanan untuk menyediakan jasa di bidang telekomunikasi. Pemanfaatan jasa telekomunikasi memberikan eksternalitas positif dan eksternalitas negatif. Akses jasa telekomunikasi paling banyak menggunakan telepon seluler. Salah satu efek negatif penggunaan ponsel adalah radiasi yang dipancarkan yang menimbulkan electrical hipersensitivity serta beberapa gangguan kesehatan seperti vertigo, sampai penyakit berbahaya seperti kanker. Dampak negatif perkembangan teknologi informasi diantaranya adalah penggunaan, penghancuran, dan modifikasi data yang tidak terotorisasi, ancaman keamanan, pelanggaran hak cipta, cybercrime, pornografi, perjudian, dan penipuan. Pasal 2 Ayat 1 Undang-Undang Republik Indonesia nomor 39 tahun 2007 tentang Perubahan atas Undang-Undang nomor 11 tahun 1995 tentang Cukai menyebutkan barang kena cukai memiliki sifat atau karakteristik : peredarannya perlu diawasi atau pemakaiannya dapat menimbulkan dampak negatif bagi masyarakat atau lingkungan hidup. Pasal 4 Ayat 2 menyebutkan penambahan atau pengurangan jenis BKC diatur lebih lanjut dengan Peraturan Pemerintah. Penggunaan jasa telekomunikasi memenuhi kriteria pengenaan cukai dengan 2 karakteristik tersebut. Penelitian bertujuan untuk menilai kelayakan dan menghitung potensi penerimaan negara dari cukai jasa telekomunikasi. Metodologi penelitian dilakukan dengan studi literatur. Hasil penelitian dapat digunakan sebagai bahan pertimbangan penambahan objek cukai di masa mendatang serta gambaran desain pengenaan cukai yang dapat digunakan.
LONG-TERM TREATMENT OUTCOMES IN COMMUNITY-ACQUIRED COVID-19 VIRAL PNEUMONIA ASSESSED BY COMPUTED TOMOGRAPHY DATA
Authors: Yakovenk O. K. , Ignatieva V. I. , Gumeniuk G. L. , Tarasenko O. R. , Svyatnenko V. A. , Lynnyk M. I.
Published: July 2022

The aim was to study the evolution of changes in the structure of the lungs in patients with a complicated course of community-acquired COVID-19 viral pneumonia by software processing of CT scan data and to determine the features of changes to predict its outcome. Materials and methods. The analysis of CT scan series of 70 patients with community-acquired viral pneumonia (COVID-19) was performed. The diagnosis of COVID-19 was established in accordance with the current protocols for the treatment of coronavirus disease. CT scan was performed on the scanner Aquilion TSX-101A “Tochiba” (Japan) with the recording of the results on digital media and subsequent software processing of data. Results. Of the 70 study patients in 21 patients (30 % of all examined subjects, 15 men and 6 women) bullous-emphysematous lesions of lung parenchyma attributable to “vanishing lung syndrome” were revealed. There were no cases of massive post-inflammatory pulmonary fibrosis found. Conclusions. Considering high prevalence of “vanishing lung syndrome” caused by the autoimmune process in patients with complicated community-acquired COVID-19 viral pneumonia, it is necessary to develop the methods of its management. To reveal complications, prevent them and predict the course of severe forms of COVID-19pneumonia, it is necessary to perform repeated CT scans with densitometry of the pulmonary parenchyma. Key words: COVID-19, CT scan, vanishing lung syndrome, densitometry, post-inflammatory pulmonary fibrosis.
PREVALENCE AND EFFECTIVENESS OF TREATMENT OF MULTIDRUG-RESISTANT TUBERCULOSIS AND DIABETES MELLITUS COMORBIDITY
Authors: Todoriko L. D. , Semianiv I. O.
Published: July 2022

The aim of the study is a comprehensive retrospective assessment of the prevalence, features, course of treatment of multidrug-resistant tuberculosis (MDR-TB) and diabetes mellitus (DM) comorbidity. Materials and methods. The study is based on an analysis of statistical data obtained from a retrospective study of 762 case histories and cases of MDR-TB in the register of tuberculosis patients from different regions of Ukraine and Grodno region of the Republic of Belarus for 2016-2020 years. In all patients MDR-TB was diagnosed retrospectively. The patients were allocated in two groups: group 1 — 88 patients with MDR-TB and DM comorbidity; group 2 — 674 patients with MDR-TB only. Results. In both study groups the recurrence of TB prevailed — 49 cases (55.7%) vs newly diagnosed TB 39 cases (44.3%) in the group 1 and 363 cases (53.9%) vs 311 (46.1%), respectively, in the group 2 (p <0.05). The rate of successful treatment in group 2 was higher than in group 1 (64.7% vs. 61.4%; (p <0.05)). However, more significant probable difference was characterized the cure rate: 27.3% in group 1 vs 40.3% in group 2 (almost 2 times; p <0.05). The rate of ineffective treatment, which in patients with comorbidity was 27.3% (almost every third patient) vs 17.6% in group 2 was also important for scientists and practitioners. Conclusions. There is a clear tendency to higher rate of comorbidities/ chemoresistance and relapses of TB in patients with comorbid DM. Pulmonary TB developed significantly more often in middle-aged patients with type 2 DM (moderate to severe, subcompensated and complicated course). Key words: resistant tuberculosis, diabetes mellitus, carbohydrate metabolism, treatment.
OPTIMAL DURATION OF INDIVIDUALIZED REGIMENS OF ANTIMYCOBACTERIAL THERAPY, CONTAINING BEDAQUILINE AND REPURPOSED MEDICINES, FOR PATIENTS WITH MULTIDRUG-RESISTANT TUBERCULOSIS INCLUDING
Authors:   SO “National institute of phthisiology and pulmonology named after F. G. Yanovsky NAMS of Ukraine”, Feschenko Y. I. , Lytvynenko N. A. , Grankina N. V. , Pogrebna M. V. , Senko Y. O. , Protsyk L. M.
Published: July 2022

OPTIMAL DURATION OF INDIVIDUALIZED REGIMENS OF ANTIMYCOBACTERIAL THERAPY, CONTAINING BEDAQUILINE AND REPURPOSED MEDICINES, FOR PATIENTS WITH MULTIDRUG-RESISTANT TUBERCULOSIS INCLUDING Y. I. Feschenko, N. A. Lytvynenko, N. V.Grankina, M. V. Pogrebna, Y. O. Senko, L. M. Protsyk Abstract The world is on the verge of a new era of antibiotic therapy due to the emergence of new drugs that can significantly reduce the overall duration of treatment for patients with tuberculosis. Aim of the study: to develop an algorithm for selecting the optimal duration of individualized regimens of antimycobacterial therapy, containin bedaquiline and repurposed drugs for patients with drugresistant tuberculosis. Materials and methods. A prospective observational study was conducted in 425 patients treated during 2017–2021. Patients were prescribed individualized therapy regimen (ITR) which included bedaquiline and repurposed drugs (without delamanid) according to the same WHO step-by-step principle, but of different duration. Patients with successful outcome were divided into 3 groups: 1st group (176 patients) with ITR duration of 12 months (less than or equal to 400 days); 2nd group (170 patients) – 13-16 months; 3rd group (79 patients) – 16-20 months. Results and discussion. Among patients treated for more than 12 months, there were significantly more pre-treatment patients with common destructive lesions in the lungs (cavities preserved after 6 month of treatment) and fluoroquinolone resistance, treated with second line antimycobacterial medications. There was a clear relationship between patients in the comparison groups: in groups 1 and 2 a cessation of bacterial excretion was significantly more often registered at the 1st-2nd month of treatment (p <0.05). The average term of culture negativity in groups 1 and 2 was — (50.3 ± 2.9), (44.4 ± 2.2) days, respectively, vs group 3 — (61.1 + 5.0) days, (p <0.05). Conclusion. The decision on the optimal duration of ITR should be made at 6 months from the beginning of treatment, based on the main (early period of negative culture) and additional criteria (no destructive changes in the lungs at 6 months, no resistance to fluoroquinolones and history of past second line antimycobacterial treatment). Key words: tuberculosis, individualized treatment regimens
Smart Home With CyberSecurity Features
Authors: Rafay Abdur , Haider Farrah , Sami Hammad , Hussain Shafiq
Published: July 2022

Nowadays, security threats are becomingimportant problem in the world. Everyone inthis world want to keep an aye on his housedue to threats and risk of theft and robbery,danger of leaking raw gas, and also requiressafety from fire, at the same time they wantto save energy, and also want to keep an eyeon their house if there are elders or disabledperson in the house.
PEMBENTUKAN DAN SISTEM PEMERINTAH DAERAH DALAM MEWUJUDKAN MANAJEMEN SUMBER DAYA MANUSIA DAN APARATUR YANG BERSIH DAN PROFESIONAL
Authors: Janna Miftahul
Published: July 2022

Keberhasilan pembentukan sistem pemerintahan dapat dicapai jika landasan dasar, yaitu sumber daya manusia aparatur telah mampu dikelola dengan optimal dan berkelanjutan. Agar reformasi manajemen aparatur dapat terwujud, ada 2 pendekatan yang dapat digunakan seperti, Pendekatan eksternal, meliputi pendekatan kebijakan dan sistem, serta pendekatan internal, meliputi pendekatan pengembangan budaya dan penanaman nilai-nilai organisasi. Pendekatan-pendekatan tersebut perlu di pahami dan menjadi poin utama dalam menetapkan arah kebijakan pengelolaan aparatur yaitu lebih produktif, efisien, dan efektif.
Differential expression of ribosomal protein S24 in cancers of the breast.
Authors: Mamoor Shahan
Published: July 2022

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with early-onset breast cancer. We found significant differential expression of the gene encoding ribosomal protein S24, RPS24, when comparing primary tumors of the breast to the tissue of origin, the normal breast: in women aged 45 and younger, and women aged 70 and higher. RPS24 was also differentially expressed in the brain metastases of patients with brain metastatic breast cancer. RPS24 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of RPS24 in primary tumors of the breast was correlated with overall survival in patients with HER2+ subtype breast cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. RPS24 may be of relevance to initiation, maintenance or progression of cancers of the female breast.
Descompensación y desajuste en la financiación de las bibliotecas públicas de España y relación con su uso: análisis basado en los indicadores de esfuerzo por comunidades autónomas
Authors: Lázaro-Rodríguez Pedro
Published: July 2022

En esta ponencia se lleva a cabo un análisis de las bibliotecas públicas de España basado en los indicadores de esfuerzo en presupuesto, en préstamos y en visitas. Estos indicadores ponen en relación el porcentaje de población de cada comunidad autónoma con el porcentaje de sus préstamos y de sus visitas, permitiendo delimitar esfuerzos negativos y positivos y concluir cualitativamente sobre los sistemas o redes de lectura pública. Si el esfuerzo es positivo, quiere decir que el porcentaje de financiación, préstamos o visitas, es mayor que el porcentaje en población, resultando un buen sistema. Si el esfuerzo es negativo, el sistema estaría en una mala y mejorable situación. El análisis se lleva a cabo con datos de 2019, último año disponible. Andalucía es la comunidad autónoma con esfuerzos más bajos con los esfuerzos negativos más altos, lo que quiere decir que presenta un desajuste en su financiación y en el uso de las bibliotecas. Islas Canarias y la Comunidad Valenciana también presentan esfuerzos negativos. Por su lado, Cataluña destaca como la comunidad con esfuerzos positivos más altos, seguida del País Vasco. Estas dos comunidades pueden ser consideradas como los modelos de buenas prácticas en lo que a financiación y uso se refiere. Los resultados se discuten poniendo en relación la financiación con el uso de las bibliotecas públicas y atendiendo a la la legislación bibliotecaria a nivel de la administración general del estado y la autonómica.
APARATUR SIPIL NEGARA (ASN) MERUPAKAN SDM YANG MENJADI FAKTOR SENTRAL PENGGERAK RODA PEMERINTAHAN NEGARA KESATUAN REPUBLIK INDONESIA
Authors: Naswa
Published: July 2022

Aparatur sipil negara (ASN) mempunyai peran penting dan menentukan dalampenyelenggaraan pemerintahan negara sesuai peraturan perundang-undangan untuk mewujudkan tujuan dan sasaran-sasaran penyelenggaraan pelayanan publiknya telah ditentukan dalam rangka tujuan nasional. Untuk itu sebagaimana disebutkan dalam penjelasan umum Undang-Undang nomor 5 tahun 2014 tentang aparatur sipilnegara, diperlukan ASN yang professional, bebas dari intervensi politick, bersuhdari praktik kkorupsi, kolusi dan nevotisme, mampu menyelenggarakan pelayanan public bagi masyarakat dan mampu menjalanan peran sebagai perekat persatuan dan kesatuan bangsa berdasarkan Pancasila danUUD 1945
Rural revival? The rise in internal migration to rural areas during the COVID-19 pandemic. Who moved and where?
Authors: González-Leonardo Miguel , Rowe Francisco , Fresolone-Caparrós Alberto
Published: July 2022

During the outbreak of the COVID-19 pandemic, anecdotal evidence of a “rural revival” emerged mirroring the “urban exodus” hypothesis. Currently, we know that internal migration to rural areas increased in some countries during 2020, although not with the intensity speculated by the media. However, little is known about the attributes of rural areas attracting migrants and demographic composition of migration inflows. Drawing on administrative population register data, we analysed the main types of rural areas pulling internal migrants in Spain and their demographic characteristics, namely age, sex and place of birth. Our results show that in-migration increased in rural areas close to cities and with high prevalence of second homes. Inflows to rural areas comprised migrants across a wide age spectrum, from young adults and families to retired individuals. These flows also comprised foreign-born populations from high socio-economic background, particularly Latin Americans and individuals from high-income countries. Our findings suggest unequal impacts of the COVID-19 pandemic on the conterurbanisation process, triggering population movements among high-socioeconomic groups from cities to rural areas
PSD - Bùi Duy Linh
Authors: TKLV QLKT
Published: July 2022

Và một trong những chủ thể của nền kinh tế trong quá trình tăng trưởng và phát triển kinh tế được đề cập ở đây là khu vực kinh tế tư nhân. Phát triển kinh tế tư nhân đã trởthành động lực quan trọng trong kinh tế thị trường định hướng xã hội chủ nghĩa, phát triển kinh tế tư nhân nhanh, bền vững với tốc độ tăng trưởng cao cả về số lượng, quy mô, chất lượng và tỷ trọng trong tổng sản phẩm nội địa (GDP). Tuy nhiên, có mối quan hệ nào giữa phát triển khu vực tư nhân và bất bình đẳng tại Việt Nam hay không? Liệu phát triển kinh tế khu vực tư nhân có tác động đến việc giảm bất bình đẳng tại Việt Nam hay không hay ngược lại, nó ngày càng gia tăng dẫn đến việc gia tăng bất bình đẳng?
Differential expression of GTF2IRD2 in cancers of the breast.
Authors: Mamoor Shahan
Published: July 2022

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with early-onset breast cancer. We found significant differential expression of the gene encoding GTF2I repeat domain-containing 2, GTF2IRD2, when comparing primary tumors of the breast to the tissue of origin, the normal breast: in women aged 45 and younger, and women aged 70 and higher. GTF2IRD2 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. GTF2IRD2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.
The Stark Realities of Reproducible Statistically Orientated Sociological Research: Some Newer Rules of the Sociological Method
Authors: Connelly Roxanne , Gayle Vernon
Published: July 2022

There is increasing concern that research is not transparent and that empirical results are often impossible to reproduce. Guidelines for undertaking reproducible research have been proposed by a number of academic areas (e.g. computational economics, psychology and medical research), however currently there are no guidelines for sociological research. This methodological paper provides guidance for undertaking reproducible statistically oriented sociological research. We provide an extended demonstration of the issues associated with reproducing results and undertaking transparent analyses. We draw on suitable concepts and techniques from open research, e-research and computing. We propose a set of Newer Rules of the Sociological Method, for undertaking transparent statistically oriented sociological research that supports reproducibility.
Pemerintahan Yang Cerdas Yang Dibutuhkan Dimasa Revolusi Industri 4.0
Authors: RAMADHANI NURUL
Published: July 2022

Kemajuan ilmu pengetahuan, komunikasi, dan teknologi informasi Pembangunan ekonomi dan perdagangan. Menyebabkan pemerintah menghadapi kerumunan yang menjadi semakin liberal dan individualistis Ada kecenderungan mengingkari eksistensi martabat, budaya dan agama. Massa orang yang lebih kritis dan rasional telah dilaporkan Perhitungan laba rugi atau akuntansi yang terukur secara ekonomis. Pragmatis. Menggabungan pragmatisme dan sekularisme dalam kehidupan sosial Di sisi lain, tradisionalisme dan agama masih sejahtera di Indonesia. Promosi Ini, membawa pragmatisme dan pola berpikir sekuler Memperkuat sikap toleran warga. Orang-orang adalah Kelompok dengan manfaat ekonomi yang sama sambil terus mencari Klasifikasi masyarakat berdasarkan perbedaan dan kriteria Secara ekonomis. Oleh karena itu, pemerintah harus cerdas menghadapi perkembangan zaman Globalisasi dan Revolusi dengan keyakinan penuh 4.0, Di atas segalanya, tantangan globalisasi dan revolusi digital tidak dapat diatasi. menghindari di mana perbatasan antar negara menjadi semakin transparan.