bluuebunny/crossref_metadata_2025 huggingface dataset:
Oral health experiences of people living with Parkinson's disease: a scoping review
Authors: E. Tebbutt Jessie , Marshman Zoe , R. Baker Sarah
Published: February 2024

Background and aim Parkinson's disease is the fastest growing and second most common progressive neurodegenerative condition in the UK; poised to represent a major societal and health care challenge. The scoping review aims to provide an overview of the literature on the oral health (OH) experiences of people living with Parkinson's, identifying current research gaps and future priorities.

Method Search strategies included three electronic databases, two grey literature databases, relevant organisations, specialist journals and hand searching of the reference lists. A data extraction tool was developed and piloted.

Results A total of 121 items were included in the review. Four themes were identified: OH impact, education and training, service delivery and wider impacts of OH for people with Parkinson's (PwP). The majority of studies included were cross-sectional in design, describing the OH status of PwP.

Conclusion The majority of research to date has focused on OH impact. Areas for future research include use of qualitative studies exploring the experiences, attitudes and priorities of PwP and their care partners. Inclusion of medical, dental and allied health care professionals, together with people with lived experience, is required to develop, implement and evaluate interventions to support OH.
The nuclear factor ID3 endows macrophages with a potent anti-tumour activity
Authors: Deng Zihou , Loyher Pierre-Louis , Lazarov Tomi , Li Li , Shen Zeyang , Bhinder Bhavneet , Yang Hairu , Zhong Yi , Alberdi Araitz , Massague Joan , Sun Joseph C. , Benezra Robert , Glass Christopher K. , Elemento Olivier , Iacobuzio-Donahue Christine A. , Geissmann Frederic
Published: February 2024

Macrophage activation is controlled by a balance between activating and inhibitory receptors1–7, which protect normal tissues from excessive damage during infection8,9 but promote tumour growth and metastasis in cancer7,10. Here we report that the Kupffer cell lineage-determining factor ID3 controls this balance and selectively endows Kupffer cells with the ability to phagocytose live tumour cells and orchestrate the recruitment, proliferation and activation of natural killer and CD8 T lymphoid effector cells in the liver to restrict the growth of a variety of tumours. ID3 shifts the macrophage inhibitory/activating receptor balance to promote the phagocytic and lymphoid response, at least in part by buffering the binding of the transcription factors ELK1 and E2A at the SIRPA locus. Furthermore, loss- and gain-of-function experiments demonstrate that ID3 is sufficient to confer this potent anti-tumour activity to mouse bone-marrow-derived macrophages and human induced pluripotent stem-cell-derived macrophages. Expression of ID3 is therefore necessary and sufficient to endow macrophages with the ability to form an efficient anti-tumour niche, which could be harnessed for cell therapy in cancer.
Comparative overall survival of CDK4/6 inhibitors in combination with endocrine therapy in advanced breast cancer
Authors: Kappel Coralea , Elliott Mitchell J. , Kumar Vikaash , Nadler Michelle B. , Desnoyers Alexandra , Amir Eitan
Published: February 2024

Individual trials of abemaciclib, palbociclib, and ribociclib show a similar impact on progression-free survival yet differing statistical significance for overall survival (OS). A robust comparative evaluation of OS, safety, and tolerability of the three drugs is warranted. A systematic literature search identified phase 3 randomized clinical trials reporting OS of CDK4/6 inhibitors (CDK4/6i) in combination with endocrine therapy in ER-positive/HER2-negative advanced breast cancer. Trial-level data on OS and common and serious adverse events (AE) were extracted for each drug. In the absence of direct comparisons, a network meta-analysis was performed to evaluate pairwise comparative efficacy, safety, and tolerability of each of the CDK4/6i. Seven studies comprising of 4415 patients met the inclusion criteria. Median follow-up was 73.3 months (range: 48.7–97.2 months). There were no statistically significant differences in OS between any of the CDK4/6i. Compared to palbociclib, ribociclib and abemaciclib both showed significantly higher GI toxicity (grade 1–2 vomiting OR 1.87 [95% CI 1.37–2.56] and OR 2.27 [95% CI 1.59–3.23] respectively). Compared to palbociclib, abemaciclib was associated with more grade 3–4 diarrhea OR 118.06 [95% CI 7.28–1915.32]. In contrast, palbociclib was associated with significantly more neutropenia than ribociclib and abemaciclib but significantly lower risk of grade 3–4 infections. Abemaciclib had significantly less grade 3–4 transaminitis and grade 3–4 neutropenia than ribociclib. Treatment discontinuation and death due to AE were significantly higher with abemaciclib than palbociclib and ribociclib. There is no statistically significant difference in OS between CDK4/6i despite differing statistical significance levels of individual trials. Real-world data analyses may help to identify if there is a meaningful inter-drug difference in efficacy. Significant differences between CDK4/6i are observed for safety and tolerability outcomes.
Investigating bacteriophages as a novel multiple-hurdle measure against Campylobacter: field trials in commercial broiler plants
Authors: Bogun Katrin , Peh Elisa , Meyer-Kühling Borris , Hartmann Jürgen , Hirnet Juliane , Plötz Madeleine , Kittler Sophie
Published: February 2024

Campylobacter mitigation along the food production chain is considered effective for minimizing the public health burden of human campylobacteriosis. This study is the first combining different measures in a multiple-hurdle approach, using drinking water additives and feed additives in single and combined application schemes in commercial broiler plants. Broiler chickens in the study groups were naturally contaminated with Campylobacter. Application of an organic acid blend via drinking water, consisting of sodium propionate, potassium sorbate, and sodium diacetate, resulted in significant reductions of up to 4.9 log10 CFU/mL in fecal samples and in cecal samples at slaughter. The application of a phage mixture, consisting of Fletchervirus phage NCTC 12673 and Firehammervirus phage vB_CcM-LmqsCPL1/1, resulted in reductions of up to 1.1 log10 CFU/mL in fecal samples 1 day after dosing. The sole administration of curcumin via feed resulted in small and inconsistent reductions. In the group receiving a combination of all tested measures, reductions of up to 1.1 log10 CFU/mL were observed. Based on the results of our field trials, it was shown that both the sole application and the combined application of mitigation measures in primary production can reduce the Campylobacter load in broiler chickens, while no synergism could be observed.
Discovery of novel DNA methylation biomarker panels for the diagnosis and differentiation between common adenocarcinomas and their liver metastases
Authors: Draškovič Tina , Hauptman Nina
Published: February 2024

Differentiation between adenocarcinomas is sometimes challenging. The promising avenue for discovering new biomarkers lies in bioinformatics using DNA methylation analysis. Utilizing a 2853-sample identification dataset and a 782-sample independent verification dataset, we have identified diagnostic DNA methylation biomarkers that are hypermethylated in cancer and differentiate between breast invasive carcinoma, cholangiocarcinoma, colorectal cancer, hepatocellular carcinoma, lung adenocarcinoma, pancreatic adenocarcinoma and stomach adenocarcinoma. The best panels for cancer type exhibit sensitivity of 77.8–95.9%, a specificity of 92.7–97.5% for tumors, a specificity of 91.5–97.7% for tumors and normal tissues and a diagnostic accuracy of 85.3–96.4%. We have shown that the results can be extended from the primary cancers to their liver metastases, as the best panels diagnose and differentiate between pancreatic adenocarcinoma liver metastases and breast invasive carcinoma liver metastases with a sensitivity and specificity of 83.3–100% and a diagnostic accuracy of 86.8–91.9%. Moreover, the panels could detect hypermethylation of selected regions in the cell-free DNA of patients with liver metastases. At the same time, these were unmethylated in the cell-free DNA of healthy donors, confirming their applicability for liquid biopsies.
ZFP36 disruption is insufficient to enhance the function of mesothelin-targeting human CAR-T cells
Authors: Mai David , Boyce Tifara , Mehta Aakash , Reff Jordan , Scholler John , Sheppard Neil C. , June Carl H.
Published: February 2024

Loss of inflammatory effector function, such as cytokine production and proliferation, is a fundamental driver of failure in T cell therapies against solid tumors. Here, we used CRISPR/Cas9 to genetically disrupt ZFP36, an RNA binding protein that regulates the stability of mRNAs involved in T cell inflammatory function, such as the cytokines IL2 and IFNγ, in human T cells engineered with a clinical-stage mesothelin-targeting CAR to determine whether its disruption could enhance antitumor responses. ZFP36 disruption slightly increased antigen-independent activation and cytokine responses but did not enhance overall performance in vitro or in vivo in a xenograft tumor model with NSG mice. While ZFP36 disruption does not reduce the function of CAR-T cells, these results suggest that singular disruption of ZFP36 is not sufficient to improve their function and may benefit from a multiplexed approach.
History of the streptothricin antibiotics and evidence for the neglect of the streptothricin resistome
Authors: Franck Ezabelle , Crofts Terence S.
Published: February 2024

The streptothricin antibiotics were among the first antibiotics to be discovered from the environment and remain some of the most recovered antimicrobials in natural product screens. Increasing rates of antibiotic resistance and recognition that streptothricin antibiotics may play a role in countering so-called super-bugs has led to the re-evaluation of their clinical potential. Here we will review the current state of knowledge of streptothricins and their resistance in bacteria, with a focus on the potential for new resistance mechanisms and determinants to emerge in the context of potential widespread clinical adoption of this antibiotic class.
Humidity-responsive self-assembly of short peptides with super-flexibility
Authors: Zhu Zhongjie , Yang Jinrong , Zhao Hongwei , Wu Yu , Bai Tanglong , Zhang Hongti , Song Yongshun , Ji Te , Hu Jun , Gao Yi
Published: February 2024

Self-assembly of short peptides stands as a pivotal avenue in the development of functional materials.
Density functional theory methods applied to homogeneous and heterogeneous catalysis: a short review and a practical user guide
Authors: Butera Valeria
Published: February 2024

A rational and practical guide for the application of DFT methods in the wide field of catalysis.
Endothelial Neuropilin-1: a multifaced signal transducer with an emerging role in inflammation and atherosclerosis beyond angiogenesis
Authors: Chikh Anissa , Raimondi Claudio
Published: February 2024

Neuropilin-1 (NRP1) is a transmembrane glycoprotein expressed by several cell types including, neurons, endothelial cells (ECs), smooth muscle cells, cardiomyocytes and immune cells comprising macrophages, dendritic cells and T cell subsets. Since NRP1 discovery in 1987 as an adhesion molecule in the frog nervous system, more than 2300 publications on PubMed investigated the function of NRP1 in physiological and pathological contexts. NRP1 has been characterised as a coreceptor for class 3 semaphorins and several members of the vascular endothelial growth factor (VEGF) family. Because the VEGF family is the main regulator of blood and lymphatic vessel growth in addition to promoting neurogenesis, neuronal patterning, neuroprotection and glial growth, the role of NRP1 in these biological processes has been extensively investigated. It is now established that NRP1 promotes the physiological growth of new vessels from pre-existing ones in the process of angiogenesis. Furthermore, several studies have shown that NRP1 mediates signalling pathways regulating pathological vascular growth in ocular neovascular diseases and tumour development. Less defined are the roles of NRP1 in maintaining the function of the quiescent established vasculature in an adult organism. This review will focus on the opposite roles of NRP1 in regulating transforming growth factor β signalling pathways in different cell types, and on the emerging role of endothelial NRP1 as an atheroprotective, anti-inflammatory factor involved in the response of ECs to shear stress.
Feasibility of an Adaptive Version of the Everyday Conversational Sentences in Noise Test
Authors: Miles Kelly , Best Virginia , Buchholz Jörg M.
Published: February 2024

Purpose:

To investigate potential reasons for the mismatch between laboratory/clinic-based sentence-in-noise performance and real-world listening abilities, we recently developed a corpus of natural, spontaneously spoken speech with three vocal effort levels (Everyday Conversational Sentences in Noise [ECO-SiN]). Here, we examined the feasibility of using the ECO-SiN corpus for adaptive speech-in-noise testing, which might be a desirable format in certain situations (e.g., during a clinical visit).

Method:

Ten young, normal-hearing adults, along with 20 older adults with hearing loss participated in the study. Speech reception thresholds (SRTs) were obtained using ECO-SiN sentences, which were systematically compared to the SRTs obtained using traditional Bamford-Kowal-Bench–like sentences.

Results:

Results demonstrated the properties of the test compared favorably with those of a standard test based on scripted and clearly spoken sentences. Moreover, whereas normal-hearing listeners received a benefit from an increase in vocal effort, the participants with hearing loss showed a disbenefit that increased with increasing hearing loss.

Conclusion:

The adaptive version of the ECO-SiN test is feasible for research and clinical testing.

Supplemental Material:

https://doi.org/10.23641/asha.25146338
A Trade-off between Overstock and Stockouts of a Perishable Raw Material with Uncertain Demands in a Cosmetics Industry
Authors: Kurniawan Dwi , Fadhilah Althofian Aditya , Suci Yuniar Sri
Published: February 2024

An inventory system is a crucial aspect of any business that deals with physical goods or products. It refers to the processes, software, and strategies put in place to track and manage the company’s inventory efficiently. In a fluctuating demand situation, the importance of an inventory system becomes even more pronounced. Managing inventory effectively becomes challenging when demand is unpredictable, and having a robust inventory system can make a significant difference. A cosmetics manufacturer produces four types of body scrubs from the same type of rice groats under fluctuating product demand conditions and limited raw material shelf life, resulting in high inventory costs due to unoptimized raw material purchasing. A probabilistic inventory system was proposed based on the newsvendor model, where demands were assumed to be normal distributed. Our computation showed that the optimal rice procurement was 2,235.69 kg/month resulting a service level of 90 percent. The proposed inventory policy was able to increase the expected monthly profit from Rp 11.3 million to Rp 14.2 million, equivalent to a 25 percent increase. Results and insights for future research were discussed.
The Recommendations to Improve Quality of Kitchen Set Products Using New Failure Mode and Effect Analysis and Fault Tree Analysis Methods at a Furniture Company in Bandung
Authors: Irianti Lauditta , Fauzan Muhammad Fikri
Published: February 2024

The company had a problem regarding product quality, especially on kitchen set products. Based on data for the last six months, reveals a consistent surpassing of acceptable limits for product defects every month. This causes negative consequences, encompassing both time and cost setbacks, along with a decline in consumer confidence in the company. Therefore, there was a compelling necessity to enhance the overall quality of the products. Two methodologies, New FMEA and FTA, were used to pursue the objective. A New FMEA was used to indicate which type of defect will be prioritized (using Action Priority (AP)) and a FTA was used to identify the root cause. The process of creating a kitchen set involved 11 steps, with defect occurrences noted in 8 of these steps. Based on AP high criteria, there were 6 failure modes (from 20) that will be singled out for root cause analysis through FTA. Based on the FTA, 14 root causes require attention. The proposed recommendations involved training, material inspection, material protection, periodic maintenance, operational procedures, replacement of measuring tools, and redesign of the workstation environment. Simulations were carried out to compare before and after (if the recommendations are applied) of AP by changing the occurrence and detection values. The simulation showed a decrease in the AP classification from high to moderate, suggesting a positive impact on product quality.
The Effect of Price, Risk, and Service Quality, on Customer Satisfaction with Brand Image as Moderating Variable at Coffee Shop X
Authors: Iklima Nadila Oktavia Nur , Yuniati Mukti Yoanita , Permata Liansari Gita
Published: February 2024

High competition between coffee shops makes customer satisfaction an important factor. Previous research states that several variables influence customer satisfaction, namely price, risk, and service quality on customer satisfaction. This research aims to empirically test price, risk, and service quality on customer satisfaction, as well as the moderating role of brand image on the relationship between price and service quality on customer satisfaction using SEM-PLS 4.0. Data collection was carried out through questionnaires to 159 respondents. The test results show that there is a significant influence between price, risk, and service quality on consumer satisfaction, and there is no influence of brand image as a moderating variable in the relationship between price and service quality on consumer satisfaction.
Improving Walking Performance in Prosthetic Leg Users: The Role of Virtual Reality and Audio Feedback
Authors: Dwita Astari Pujiartati , Ashila Nurul Huda , Yassierli  , Khoirul Muslim
Published: February 2024

Virtual reality (VR) has emerged as a promising technology for enhancing the rehabilitation process and improving the life quality for lower limb prosthetic user. The integration of audio within VR environments can significantly impact the performance of lower limb prosthetic user, improve their gait patterns, enhance balance control, and avoid user from falling. This research paper investigates the effectiveness of VR and audio stimuli in improving gait in amputees wearing prosthetic legs. A VR-based training system is developed, utilizing a head-mounted display (HMD) and audio cues synchronized with footsteps or slowed down. Thirteen transfemoral prosthetic leg users participate in the study, assessing the impact on gait parameters. Participants were asked to walk in 3 conditions: without audio (WA), with audio (A), and slow tempo audio (SA). Results demonstrate significant enhancements in step length, stride length, and step time, achieving balance between the prosthetic and normal limbs. The integration of audio stimuli proves advantageous in enhancing walking performance and addressing asymmetries. The findings suggest that VR with slow-tempo audio cues holds promise for improving rehabilitation outcomes for prosthetic leg users. Future research should focus on optimizing training methods and exploring full potential of audio-integrated VR for gait rehabilitation in amputees.
Sentiment Analysis on Twitter Using Deep Belief Network Optimized with Particle Swarm Optimization
Authors: Dewi Irma Amelia , Rizqullah Muhammad Aldi
Published: February 2024

Deep Belief Network is a type of artificial neural network that is widely used in machine learning and deep learning tasks that allows it to learn hierarchical representations of the input data. However, Deep Belief Network has a drawback of being sensitive to hyperparameters. DBN has several hyperparameters that need to be chosen appropriately for the network to function effectively. Poor hyperparameter choices can lead to unstable training or poor performance. Therefore, the Particle Swarm Optimization algorithm is used to search for the best hyperparameters, which can lead to stable training and improved performance. The purpose of this study is to analyze public sentiment on Twitter using the Deep Belief Network method and to optimize it using Particle Swarm Optimization. The evaluation results obtained in this study are 71.4% accuracy, 71.7% precision, 71.4% recall, and 71.2% F1-score in the Deep Belief Network model which is optimized by the Particle Swarm Optimization algorithm, whereas when compared with the Deep Belief Network model alone gets evaluation results of 68.3% Accuracy, 69.0% Precision, 68.3% Recall and 68.0% F1-score. These results indicate that the use of the Particle Swarm Optimization algorithm is quite influential in analyzing sentiment in text.
Student’s Acceptance and Actual Use of E-Learning System in a Post-COVID Era Through Technology Acceptance Model
Authors: Umaroh Sofia , Musrini Mira , Maulana Fachri Achmad
Published: February 2024

The COVID-19 pandemic has pushed the transition of learning activities in universities into distance learning. This leads to extensive use of e-learning, which became one of key things to sustain the ongoing teaching and learning activities during the pandemic. With the return of classroom learning, the actual use, and students’ intentions on using e-learning system is unknown, and it could aﬀect e-learning system’s eﬀectiveness. Based on the problem, a quantitative research and analysis is conducted on students’ acceptance, use intentions, and actual use of e-learning system using Technology Acceptance Model (TAM) with three adopted external constructs of Learnability, Self-eﬃcacy, and Social Norm. The questionnaire result processing is conducted by utilizing Structural Equation Modelling (SEM). The findings are students’ perception of e-learning system’s usefulness, ease of use, and students’ attitude towards the e-learning system aﬀects their behavior intentions, and actual use of e-learning system. This finding also resulted on two proposed suggestions on adding minimum content requirements and standard operational procedure in course content management with the aim to increase its learnability and students’ attachments and adding a user tour feature with the aim to increase both learnability and ease of use of e-learning.
Comparison of K-Medoids and K-Means Algorithms in Segmenting Customers based on RFM Criteria
Authors: Fitrianti Fahrudin Nur , Rindiyani Rini
Published: February 2024

The company’s approach to customers is important to maintain the company’s profits. Understanding the differences of each customer is very important so that we can understand customer needs based on customer data. Customer Relationship Management (CRM) is considered as a solution to bridge the company and customers. Customer segmentation needs to be done to make it easier for companies to meet customer needs. Data mining and RFM modelling are used for customer segmentation in online retail companies using K-Means and K-Medoids methods. This research compares the performance of both algorithms using Davies Bouldin Index (DBI) and execution time. The results show K-Means is better in cluster validation and execution time. The average DBI value of K-Means is 0.2962 with an execution time of 0.0960 with k=3, while K-Medoids produces a DBI of 0.8942 and an execution time of 2.4295 with k=5. K-Means RFM customer tiers 1-3: Potential Customer/Golden Customer, Lost Customer/ Dormant Customer, and Superstar/Core Customer, 1-5: Champion and Lost. K-Medoids RFM 1-5: Lost, Loyal Customer, Champion, At Risk, and Hibernating, 1-3: Lost Customer/Dormant Customer, Potential Customer/Golden Customer, Superstar/Core Customer, Potential Customer/Golden Customer, and At Risk Customers/Occasional customer.
Classification of Roasted Coffee Beans with Principal Component Analysis and Random Forest
Authors: Miftahuddin Yusup , Rais Refda
Published: February 2024

Roasted Robusta coffee beans originating from Toraja and Ciwidey, Indonesia have the same shape, color and characteristics of the coffee beans. There is often an error in recognizing coffee bean varieties just by looking with the naked eye. In terms of image classification, Random Forest has stable performance and performance. This research aims to classify coffee beans based on images of roasted coffee beans using the Random Forest and PCA algorithms. The steps taken were collecting Robusta and Toraja datasets which were taken manually and given 2000 labels. Data collection was carried out using a light intensity of 300 lux and a distance of 15 cm. The data was preprocessed, variables were reduced using PCA and Random Forest in forming the model. Testing uses 1600 training data and 400 test data to measure RF performance by changing the parameters of the number of data sets and the n value in Random Forest with the highest accuracy value of 98.05% with a value of n = 20 and 360 data tested.
Elevating Sustainability and Profitability: Non-Precious Metal Nano Catalysts for Maximizing Yield and Calorific Value in Asphalt Pyrolysis
Authors: Yolandha Parapat Riny , Zamaludin  , Firmansyah Rizkiawan Putra Muhamad , Aschuri Imam , Agustian Didin , Schomäcker Reinhard
Published: February 2024

Pyrolysis has proven to be a promising method for converting complex organic materials such as asphalt into high-value products. In an effort to increase the economic efficiency of this process, we investigated the use of non-precious metal nano catalysts for asphalt pyrolysis. Non-precious metal nano catalysts were chosen because of their potential to increase reaction rates and optimize product yields. This research involves the preparation of non-precious metal nano catalysts and their implementation in the asphalt pyrolysis process. The temperature and pyrolysis time variables are varied to determine optimal conditions. The results showed that the use of non-precious metal nano catalysts resulted in a significant increase in the yield of pyrolysis products, with the highest yield reaching 50.78%. In addition, the calorific value of the resulting product also increased to 10684 calories per gram. The main advantage of this research is the emphasis on economic aspects. The use of non-precious metal nano catalysts effectively increases the efficiency of the pyrolysis process, leading to higher product yields and greater calorific values. Thus, the use of non-precious metal nano catalysts makes a positive contribution in reducing production costs on an industrial scale. These findings provide new insights in the development of pyrolysis technology that is sustainable and economical and encourages a wiser use of natural resources through the use of bitumen and other complex organic materials.
Effect of Substrate Concentration (Glucose) on Ethanol Fermentation Continue with Immobilized Fixed Bed Fermenter for 2/3 Mesh Pumice Anchoring Size
Authors: Nabila Baharudin Fatwa , Naufal Ramadhan Faris , Samsuri Muhamad , Kurniawan Ronny
Published: February 2024

The need for ethanol which is increasing at all times demands development related to ethanol production, especially those produced through the fermentation process both development in terms of raw materials and processes. Ethanol fermentation process continues to have problems one of them is wash out or the carrying of microorganisms into the product stream which causes the number of microorganisms to continue to decrease in the fermenter. One way to solve the problem of wash out is to tether the microorganism first to the anchoring medium (immobilized cell) and choose the suitable type of fermenter. The purpose of this study was to determine the effect of glucose concentration and the best conditions on the ethanol fermentation process continue with immobilized cell fixed bed fermenter to the value of ethanol concentration and yield ethanol produced as well as the percent of microorganisms still carried into the product streams. Based on the results of the study, the best conditions were obtained with a residence time of 2 days with the ethanol concentration of 1.20%v/v, the yield of fermented ethanol was 37.75%w/w, and % number of cells released was 0.45% at a glucose feed concentration of 150g/L. Fermentation is carried out under conditions of immobilized cell using microorganisms from the type of yeast Saccharomyces cerevisiae. In this study the variables that were considered fixed were the expansion ½ height of 1.47m column height, temperature of 25-30°C, and a pH of 5.5.
Research Collaboration of ITENAS Bandung – Indonesia and MATE Godollo – Hungary on the Photovoltaic Thematic Field: Achievements and Future Plan
Authors: Rusirawan Dani , Hartawan Liman , Lidyawati Lita , Bozikova Monika , Hlavacova Zuzana , Libra Martin , Seres Istvan , Vig Piroska , Farkas Istvan
Published: February 2024

Since the agreement was signed officially in 2013, Institut Teknologi Nasional Bandung (ITENAS Bandung) – Indonesia and Hungarian University of Agriculture and Life Sciences (MATE Godollo) – Hungary have implemented a lot of scholarly activities, and one of them is research collaboration in the field of solar energy, especially in the thematic field of photovoltaic (PV). A set of experimental facilities has been developed and constructed to support related research. Basic facilities to understand the principle of electricity generated by PV, i.e., having the solar power plant (SPP) laboratory scale have been fulfilled by both universities. MATE Godollo has a 10 kWp SPP installation and uses polycrystalline and amorphous silicon PV modules, meanwhile, ITENAS Bandung has 1 kWp SPP and uses monocrystalline silicon PV modules. In this paper, a set of activities related to PV research collaboration between ITENAS Bandung and MATE Godollo will be elaborated, including the output and the outcome of the activities, and plan activities involving other university partners, Slovak University of Agriculture in Nitra – Slovakia and Czech University of Life Science Prague, Czech Republic.
Overview of the IX International Conference on Advanced Agritechnologies, Environmental Engineering and Sustainable Development – AGRITECH-IX – 2023
Authors: Mamatkarimov Odiljon , Ergashev Oybek , Giyasidinov Abduaziz , Sharipov Mirzo , Abrorov Akbar , Khakimova Nasiba , Kovalev Igor
Published: February 2024

The overview describes the main directions and results of the IX International Conference “AGRITECH-IX-2024” held in Namangan, Uzbekistan. It gives the details about the participants and the proceedings. The anchor partners of Krasnoyarsk Science and Technology City Hall were Krasnoyarsk State Agrarian University, Ufa State Petroleum Technological University, Ufa, Republic of Bashkortostan, the Volga Region Research Institute of Manufacture and Processing of Meat-and-Milk Production, Volgograd, Russia, Bukhara Engineering Technological Institute, Bukhara and Namangan Engineering Technological University, Namangan, Uzbekistan, Zhetysu University named after I. Zhansugurov, Taldykorgan, Kazakhstan. The Innovation Scientific Consulting Center (Uzbekistan) and Siberian Scientific Centre DNIT (Russia) sponsored the Conference.
Analysis of the palm oil quality for the production of DIY non-food products
Authors: Goncharenko Oksana , Zolotova Svetlana , Goryunova Olga
Published: February 2024

One of the current trends in the modern market is the use of palm oil as a raw material for the production of DIY non-food products, in particular cosmetic products. The work examined the organoleptic and physicochemical parameters of non-food palm oil intended to produce cosmetics and sold through marketplaces on the Internet. The purpose of the study is to verify the compliance of these goods with mandatory quality and safety requirements. As a result of the study, the problem of non-compliance of samples with standard requirements both in terms of labeling and values of organoleptic, physical and chemical quality indicators was identified. Such factors potentially pose a risk to consumer health.
The effect of alcohol on the preservation of the nutritional value of the haylage when it is packed in agrostretch film
Authors: Chernyshev Alexey D. , Kostenko Mikhail Y. , Antonenko Nadezhda A. , Baidov Anton V. , Zotikova Valeria M.
Published: February 2024

The article discusses the issue of the formation of alcohol vapor in haylage packaged in agrostretch film. The haylage includes ryegrass and alfalfa, which makes it possible to provide the entire livestock complex with a high-quality feed mixture. It was established that at the time of harvesting and packaging of haylage, the percentage of alcohol settled at 2.6%. The observation period for changes in the percentage of alcohol inside a soft container made of agrostretch film was 11 days. As a result of research, it was found that the percentage of alcohol decreases sharply and already on the tenth day becomes zero. At the same time, the percentage of carbon dioxide in the packaged haylage increases, which prevents the development of pathogenic microflora and the formation of fungi.
Analysis of the current state of small business and private entrepreneurship development
Authors: Rashidov Rahmatullo A.
Published: February 2024

The small business sector is gaining importance as a basis for structural change of the regional economy in creating healthy competition conditions, ensuring employment of the population, and solving the problems of filling the market with goods. In the system of the internal market economy, entrepreneurship is increasingly forming the basis of production, it is becoming crucial in establishing the processes of reducing poverty and ensuring economic growth. The development of small business enterprises is of great importance for the development of the entire country and its regions, as it is a source of economic growth. The unique experience gathered by local enterprises and the positive results of small business development in countries that have passed the stage of economic system reform indicate that small business has achieved great success in the process of forming the market system. In this regard, it remains relevant to study the main conditions, trends and characteristics of small business development in the region.
Quantitative PCR to determine the titer of infectious activity of the canine hepatitis virus
Authors: Doronin Maxim I. , Mikhalishin Dmitry V. , Shishkova Angela A. , Galkina Tatiana S. , Shishkov Alexander V. , Malygin Maxim P.
Published: February 2024

This article presents data on the development and validation of a method for the indirect determination of the titer of infectivity of canine infectious hepatitis virus of genotype CAV-1 in raw materials for culture vaccines by real-time polymerase chain reaction using the Cq quantification cycle, including the following steps: eluting DNA of canine infectious hepatitis virus genotype CAV-1; performing amplification of a specific fragment orf 16 of canine infectious hepatitis virus genotype CAV-1 DNA using the original specific forward and reverse primers, as well as a molecular probe labeled with fluorescent dye FAM and luminescence quencher RTQ-1: CAV-1-T-F-primer with 5′-CGTAATGGGGAAACCTAGGGG-3′ design, CAV-1-T-R-primer with 5′-TCTGTGTTGTTTCTGTCTTGG-3′ design, and CAV-1-T-Pb-probe with 5′-FAM- CCAATCATCATCTCAACTCAACTAAATGCCGTG-RTQ1-3′ design; calculation of Cq quantification cycle from real-time PCR data; determination of the titer of infectivity of canine infectious hepatitis virus of genotype CAV-1 using a logarithmic function expressed as the equation lg TCAV-1 = -0.2979 × Ct + 9.2595 with an approximation reliability of 0.9941 and amplification efficiency of 99.38%. The analysis time is reduced to 3 h, and the analytical sensitivity is at least 1.0 lg TCD50/cm3.
The influence of the production method on the physicochemical properties of organic fertilizer obtained by vermiremediation
Authors: Еsaulko Alexander , Ozheredova Alena , Zvereva Olga , Kotova Arina , Khalikova Valeria
Published: February 2024

The research was carried out in 2022-2023 to study the effect of vermiremediation of vermicompost on the physicochemical properties. The scientific novelty of the research was that the production of environmentally friendly fertilizer was tested in various ways. Depending on the production method and dose of the biological product, the optimal chemical and physical composition of the organic fertilizer has been established. The experimental design involved the study of the following options: the dose of a biological product used for the reproduction and life of soil-forming flora (factor A), the method of producing vermicompost (factor B) - year-round and seasonal. The experiment was launched at the training and experimental station of the Stavropol State Agrarian University. When using the biological product “Baikal-1” at a dose of 70 ml/1t, the maximum yield of vermicompost was obtained - 0.53 t per 1 ton of compost, which significantly exceeded the option in which a dose of 50 ml/1 t was used by 0.03 t. Year-round production turned out to be the best in formation of optimal density and yield of vermicompost. The optimal fertilizer was obtained during year-round production using the drug Baikal EM-1 at a dose of 70 ml/1 ton.
Modeling of two-dimensional unsteady water of movement in open channels
Authors: Seytov Aybek , Abdurakhmanov Olim , Kakhkhorov Abdusalim , Karimov Davlatyor , Abduraimov Dostonbek
Published: February 2024

The article analyzed numerical methods for modeling the unsteady movement of water at water facilities, taking into account the multidimensional distribution of their parameters in space. And also, numerical methods of modeling the unsteady water movement in water management facilities have been developed, taking into account the multidimensional distribution of their parameters in space based on the finite element method, and optional features of using the finite element method for modeling unsteady water movement in water management facilities, taking into account the two-dimension of the water flow in space, have been determined.
Investigation and optimization the study of Hexavalent Chromium elimination efficiency by activated carbon prepared from modified rice husk with sorbic acid
Authors: Huong Ta Thi , Trang Tran Y. Doan , Quynh Pham Huong
Published: February 2024

The current work illustrates how successfully rice husk-activated carbon eliminates hexavalent chromium from aqueous solutions. The design of experiment (DOE) - response surface methodology (RSM) was utilized to build an appropriate experimental model. The experimental variables pH, contact length, and adsorbent dose were found, as well as their interactions and effects on Cr(VI) removal. The greatest result for Cr(VI) removal was obtained at pH = 2, agitation time of about 30.5 hours, and adsorbent dose = 4 g/l, with a starting hexavalent chromium content of 100 ppm. Hexavalent chromium removal is performed optimally under the parameters specified for these driving forces. ANOVA also demonstrated a strong coefficient of determination R2 > 99 %. Furthermore, Temkin isotherm and pseudosecond kinetic models with high R2 values were selected as useful for the inquiry. It illustrates that the removal of hexavalent chromium in studies is considered to follow a regular distribution of binding energies up to a given maximum binding energy. Furthermore, the rate of adsorption site occupancy is inversely proportional to the square of the number of unoccupied sites on the adsorbent.
Engineering and environmental surveys of a multifunctional complex of buildings and structures subject to reconstruction
Authors: Buzyakova Inna , Tomashova Anastasia , Sharova Irina , Kryzhanovskaya Galina , Bezuglova Marina
Published: February 2024

Moscow is the largest metropolis in Russia, therefore environmental problems on its territory are becoming increasingly acute (the increase in the number of vehicles, industrial enterprises and the construction of new facilities has a negative impact on the environmental situation in the city), which requires high-quality engineering and environmental surveys. Engineering and environmental surveys make it possible to assess the impact of the reconstruction of the complex on the environment, identify possible risks and take measures to prevent them. They allow considering factors such as the conservation of natural resources, limiting emissions of harmful substances and other environmental aspects. Conducting engineering and environmental surveys is important for reducing negative impacts on the environment and preserving natural resources. This is especially true in the context of growing environmental problems in the city and increasing control over their solutions by the authorities. The purpose of conducting engineering and environmental surveys of a multifunctional complex of buildings and structures subject to reconstruction is to identify recommendations and proposals aimed at reducing and preventing possible negative consequences on the environment.
Assessment of agro-recreational tourism attractiveness of the region and prospects for development of agrotourism entrepreneurship
Authors: Musakhanov Qazikhan , Bustоnоv Mansurjon M.
Published: February 2024

The tourism and recreation sector is so diverse that its development cannot be overestimated. In world practice, accounting data proposed by the World Tourism Organization are used to maintain tourism statistics, the main of which is the number of tourists visiting a certain area. The tourism industry, which covers up to 30 branches of the economy, cannot be evaluated only by the number of tourists visiting a certain area or by some other indicators.Tourism resources, including natural and anthropogenic resources, form the basis of tourism industry activity. This region attracts tourists due to the presence of objects of the conservation fund of the regions of Namangan region, mineral springs, historical and cultural monuments, favorable climatic conditions, rich flora and fauna. It is possible to get a high socio-economic effect from its development only after measures are taken to beautify the area, develop the material and technical base of agrarian tourism, etc.
A complex method for preventing collisions between mining equipment and personnel in mine conditions
Authors: Krasnov Timur V. , Romanov Viacheslav V.
Published: February 2024

The article provides an analysis of low-frequency and high-frequency methods for determining the distance between mobile equipment and personnel for the purpose of preventing collisions in difficult mine conditions. The authors assessed the influence of the geology of mine workings, the earth’s surface and transport on the electromagnetic field of the VLF, LF and C range. From the analysis, a combined design solution was derived for determining the distance in surface and underground mining conditions. The proposed methods for registering the proximity of objects compensate for each other’s vulnerabilities and make it possible to implement an integrated approach to preventing collisions of mining equipment with personnel.
The effect of vermicompost on the growth and productivity of pepper in Yakutia
Authors: Stepanova Daria I. , Grigorev Mikhail F. , Grigoreva Aleksandra I. , Stepanova Svetlana I. , Tatarinova Zinaida G.
Published: February 2024

The purpose of this paper is to presents the main results on the study of the effect of different doses of vermicompost on the growth and yield of pepper in the conditions of Yakutia. Experiments on testing fertilizers were carried out on peppers of the “Nezhnost” variety. In variant, there were 10 plants. Experimental scheme: 1 variant - was only with soil; variant 2 in addition to this vermicompost - 100 g; variant 3 vermicompost - 300 g; variant 4 vermicompost - 500 g; variant 5 - the biological product “Baikal EM 1” - 100 ml per well with 100 g semi-rotted manure. The optimal rate of application of vermicompost was determined at which plant growth increased by 20.89%, the total leaf area - by 36.55%. All this together affected the yield of pepper. The second best result was obtained when using the biological product “Baikal EM 1”. At the same time, plant growth indicators improved by 12.18%, the total area of the leaf increased by 24.72%. The data obtained complement the scientific base in the field of northern crop production in terms of the use of vermicomposts from local raw materials.
Geography of organic production for sustainable development of rural areas
Authors: Aleschenko Vitaly , Aleschenko Olga , Maksimovich Kirill , Gritsenko Galina , Shastin Anatoliy
Published: February 2024

Climate change, new government policies, and changes in the geography of exports at the present stage require an integrated approach to assessing the prospects for the development of organic production in Siberia, which can act as a growth engine for rural areas. The calculation results show that the possibilities of organic production in Siberia are differentiated according to the natural and climatic principle. Tundra and forest-tundra are characterized by developed reindeer herding. The most productive zones are the southern taiga zone, forest-steppe and steppe. Western Siberia uses arable land as its main production asset: specialization is carried out in grain production and meat and dairy cattle breeding. Eastern Siberia has magnificent pastures and hayfields with developed sheep and dairy cattle breeding. Rural areas with suburban areas can specialize in the production of milk, poultry, pork, vegetables and potatoes; beekeeping has prospects.
Global food security: developing effective approaches to sustainable development
Authors: Khryseva Anna A. , Ezangina Irina A. , Boriskina Tatyana B. , Akimova Olga E. , Evstratov Alexander V.
Published: February 2024

The agri-food complex is one of the most important sectors of the world economy, without which the very existence of mankind would be impossible. The relevance of studying the issue of global food security lies in the fact of the aggravation of the problem, which is expressed in the rapid growth of population in comparison with the growth of food production. Issues of food security remain relevant throughout the development of the economy, both at the national and global levels. This problematic issue is deeply studied by foreign and domestic researchers, who pay special attention to key aspects of national food security, such as the availability of food and the sustainability of its provision, as well as its safety and quality for human health and the environment. The insufficient knowledge of these issues, their practical significance, the controversial nature of the problems and their undoubted relevance determined the choice of research topic in this article. This review provides an analysis of the key issues and approaches that ensure the effective and sustainable functioning of the food system in the modern global economy.
Usage of irrigation elements by means of water-efficient technology in irrigating intensive apple gardens through soil and dynamics of seeping moisture
Authors: Juraev Fazliddin U. , Salman Maher , Karimov Golib H. , Ergashov Zuxriddin Ju. , Urinov Eldor F.
Published: February 2024

The article presents the results of theoretical and experimental research on the cultivation of intensive orchards with the method of watering through the soil. These methods and elements are for the first time applied to intensive gardens. During the research, we studied both the movement and height of the wetting contour over time H, the radius of the width L, and the curve area of the irrigation norm W m3/ha were relatively chosen.