bluuebunny/crossref_metadata_2025 huggingface dataset:
Tankyrase 2 as a therapeutic target in non-small cell lung cancer: Implications for apoptosis and migration
Authors: Yu Jing , Xu Bo-Tao , Li Qiu , Shang Zhong-Tu
Published: January 2025

This letter addresses Wang and Zhang's investigation into the role of tankyrase 2 (TNKS2) as a pivotal driver of malignancy in non-small cell lung cancer (NSCLC) through mechanisms including apoptosis inhibition, enhanced cellular migration, and β-catenin pathway activation. Their study in NSCLC cell lines demonstrates that TNKS2 overexpression stabilizes β-catenin, subsequently triggering oncogenic gene expression and facilitating cellular migration-key attributes of metastatic potential. These insights position TNKS2 as a compelling target for therapy and a potential prognostic marker in NSCLC. Nevertheless, translating these in vitro findings to clinical practice requires validation in in vivo models. Additionally, further research should investigate TNKS2 expression in patient samples and assess its implications in therapy resistance and combination treatment strategies.
Efficacy of disitamab vedotin-containing therapy in metastatic colorectal cancer: A case report
Authors: Yan Hu-Cheng , Liu Yan , Feng You , Li Jun-Ming , Sheng Lei-Ming , Chen Xin , Xie Yu-Ping , Li Na
Published: January 2025

BACKGROUND

Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. In cases of metastatic CRC (mCRC) that are resistant to conventional chemotherapy-based treatments, the efficacy of available therapeutic options is typically low. CRC exhibiting overexpression or amplification of the human epidermal growth factor receptor 2 (HER2) gene has shown responsiveness to HER2-targeted therapies.

CASE SUMMARY

We present the case of a 69-year-old woman diagnosed with mCRC with an NRAS p.G12V mutation and microsatellite stability, identified through tumor sequencing, along with HER2 overexpression detected by immunohistochemistry. She exhibited an excellent response to disitamab vedotin-containing therapy. To our knowledge, this is the first reported case of mCRC with HER2 overexpression and an NRAS p.G12V mutation achieving a remarkable clinical response to anti-HER2 therapy.

CONCLUSION

Disitamab vedotin demonstrates promising anti-tumor effects in HER2-overexpressing mCRC, offering patients an additional treatment option.
Mass Shootings in the 21st Century: An Examination through the Lens of the Interpersonal Psychological Theory of Suicide
Authors: Hendley Tyler , Deas Nicholas , Finnell Sophie , Kowalski Robin
Published: January 2025

Suicide-related thoughts and behaviors (SRTBs) have become identified as common antecedent experiences of mass shooters prior to and during their shootings. To better support and inform efforts of such upstream prevention and intervention efforts of mass violence, this study aimed to provide an exploratory descriptive perspective of the interpersonal experiences of mass shooters who survived and those who died on the scene (i.e., died by self-inflicted suicide, or died by police intervention) using the interpersonal psychological theory of suicide (IPTS) as a theoretical framework. Through an open-source data collection method, researchers gathered data related to the interpersonal constructs of thwarted belongingness, perceived burdensomeness, and a capability for suicide, for N = 112 mass shooters that perpetrated their crime in the 21st century. Interpersonal constructs were observed as similar across both on-scene outcomes. The interpersonal constructs of thwarted belongingness and a capability for suicide were evidenced in a majority shooters across outcomes. These results offer initial exploratory evidence that most mass shootings may, at their core, be influenced to some extent by SRTBs as described by the IPTS. By addressing mass shootings through such a point-of-view, prevention and intervention efforts may benefit from alignment with those proven efficacious for SRTBs.
The effects of childhood trauma on bullying - mental health
Authors: Jin young Hwang
Published: January 2025

Bullying is the systematic abuse of power and is defined as aggressive behavior or intentional harm-doing by peers that is carried out repeatedly and involves an imbalance of power. Being bullied is still often wrongly considered a ‘normal rite of passage’. This review considers the importance of bullying as a major risk factor for poor physical and mental health and reduced adaptation to adult roles, including forming lasting relationships, integrating into work, and being economically independent. Bullying by peers has been mostly ignored by health professionals but should be considered as a significant risk factor and safeguarding issue. In addition, the present relationship between childhood trauma and the risk of bullying, in any of the capacity to either become a target, a bully or both, is explained. The review also considered the differences between direct, relational, and cyberbullying, as well as the effects on both the target, self, and the perpetrator. Particular emphasis is placed on the cumulative response and the possible consequences of bullying in the future, including the emotional state in the form of anxiety, depression, cutting oneself, and thoughts about suicide, but only among those children who face bullying every day. Through emphasizing the intricate processes and the broad impacts of bullying, this paper supports a much-engaged approach towards such issues as: early identification of bullying; the use of school-based prevention methods, and helping the students who have been bullied.
Model Optimasi Model Optimasi Rute Transportasi Berbasis Pemrograman Linear
Authors: Nazry Hevlie Winda Nazry S , Ferdy Riza  , Firahmi Rizky  , Zuli Agustina Gultom  , Muhammad Haris  , Mika Debora Br Barus
Published: January 2025

Transportasi merupakan salah satu elemen penting dalam mendukung aktivitas logistik dan distribusi. Efisiensi dalam perencanaan rute transportasi dapat mengurangi biaya operasional, waktu tempuh, serta dampak lingkungan. Penelitian ini bertujuan untuk mengembangkan model optimasi rute transportasi berbasis pemrograman linear yang mampu memberikan solusi optimal dalam penentuan rute. Model ini mempertimbangkan berbagai parameter, seperti jarak, waktu, kapasitas kendaraan, dan batasan operasional. Pendekatan pemrograman linear untuk menemukan solusi optimal terkait penentuan rute pengiriman yang efisien, dengan memperhatikan berbagai kendala seperti kapasitas kendaraan, permintaan pelanggan, dan waktu pengiriman. Model ini terdiri dari fungsi objektif yang meminimalkan total biaya transportasi, sementara kendala yang diterapkan meliputi batasan kapasitas kendaraan, pemenuhan permintaan pelanggan, dan batasan waktu perjalanan. Hasil penelitian menunjukkan bahwa penerapan model ini berhasil menghasilkan solusi yang optimal, dengan mengurangi biaya total pengiriman secara signifikan, sekaligus memenuhi semua persyaratan dan batasan yang ada. Model ini memberikan kontribusi dalam peningkatan efisiensi pengelolaan rute transportasi dan dapat diadaptasi untuk berbagai jenis sistem distribusi yang lebih kompleks
Pengelompokkan Film Trending di Youtube Menggunakan TF-IDF dan K-Means Clastering
Authors: Remawati Dwi , Wijayanto Hendro , Wahyu Utami Yustina Retno , Raharja Bayu Dwi
Published: January 2025

YouTube telah menjadi platform utama untuk konsumsi konten video, dengan tren video yang terus berkembang sesuai perubahan minat audiens. Penelitian ini bertujuan untuk mengelompokkan film trending di YouTube berdasarkan judul dan popularitasnya menggunakan pendekatan TF-IDF dan K-Means Clustering. TF-IDF digunakan untuk mengekstraksi fitur dari judul video, mengidentifikasi kata-kata kunci penting yang mencirikan tema setiap film. Algoritma K-Means kemudian digunakan untuk mengelompokkan video ke dalam beberapa cluster berdasarkan kemiripan fitur TF-IDF dan jumlah views. Hasil penelitian menunjukkan bahwa video dapat dikelompokkan ke dalam tiga cluster dengan karakteristik unik. Cluster pertama berisi video dengan tema komedi, aktor populer, dan jumlah views tinggi. Cluster kedua mencakup video dari berbagai genre dengan jumlah views yang bervariasi. Cluster ketiga terdiri dari video yang lebih spesifik dengan popularitas tinggi. Evaluasi menggunakan Silhouette Score menunjukkan bahwa kualitas clustering masih dapat ditingkatkan. Penelitian ini memberikan wawasan bagi kreator konten dan pemasar digital untuk menyusun strategi konten yang lebih menarik dan relevan, serta memberikan kontribusi akademis dalam analisis data berbasis teks.
Homenaje a Javier Riveros Basoalto: Archivo vivo de la memoria escénica
Authors: Poblete Rodríguez Nicolás
Published: January 2025

Este artículo examina el homenaje a Javier Riveros Basoalto, desarrollado en el marco del Segundo Encuentro de Archivo, Documentación y Patrimonio Teatral, como un caso paradigmático de archivo viviente. A través de la memoria oral, gestual y emocional, se pone en valor la transmisión vivencial como una práctica legítima y dinámica para la preservación y resignificación en las artes escénicas. La experiencia se analiza bajo el marco teórico de Barba y Savarese (2005), Schechner (2006), Taylor (2003), Fischer-Lichte (2008) y Pavis (1996), quienes destacan el cuerpo y la performance como depósitos activos y transformadores de conocimiento cultural y artístico. Esta perspectiva enfatiza el archivo teatral como un espacio dinámico donde lo efímero y lo encarnado dialogan con el pasado, el presente y el futuro, ampliando las posibilidades del teatro para construir memoria y proyectar nuevas formas de creación. Este enfoque propone repensar las prácticas de archivo en el teatro chileno, posicionando la memoria corporal y la interacción humana como ejes esenciales para la conservación, resignificación y resistencia cultural.
РАЗЛИЧИЯ В ИНДЕКСАХ АГРЕССИВОВ В МЕДИАПРОСТРАНСТВЕ ВОСТОКА И ЗАПАДА: ПАРАВЕРБАЛЬНЫЙ АСПЕКТ ЭМОТИВНОГО ВОСПРИЯТИЯ
Authors: Чжан Л. , Карабулатова И.С.
Published: January 2025

Анализируются различия в восприятии агрессии в этнолингвокультурных традициях России и Китая, которые могут вызвать диссонанс искаженного восприятия медиадискурса у реципиента не только из-за разницы трактовок феномена конфликта, но и из-за фонематических особенностей разноструктурных языков. Фонематические особенности позволяют выявить паравербальные индексы агрессива в медиапространстве, обнаруживая тенденцию к росту в условиях лингвоментальной информационной войны гибридного типа. Приоритет коммуникативной активности в цифровом формате предопределил лидирующие позиции поликодового представления информации, вследствие чего дискриминационное поведение стало проявляться в поликодовом формате, с аудио- и видеопрезентациями. Заявляемая авторами агрессология рассматривает реализацию агрессии соответственно на вербальном, аудиальном (паравербальном) и невербальном гипертекстовом поликодовом уровнях. Рассмотрение паравербальных фоносемантических характеристик агрессии связано с распознаванием агрессии в речи, что является важным моментом для определения границ агрессии.
The Significance of Diversity Management and Employee Engagement in Organizations
Authors: Hawata Sabreen Mohamed
Published: January 2025

The use of diversity management strategies inside an organization may foster a corporate culture that promotes
increased employee engagement and provides individuals with the necessary tools and support to effectively advocate for
their own interests. This enhances the entire employee experience. The implementation of effective diversity management
strategies has the potential to positively impact several organizational outcomes, including productivity, employee
retention, job satisfaction, recruiting, and hiring. This study investigates the significance of diversity management and
employee engagement inside firms, with a specific focus on underrepresented groups in STEMM sectors. This paper
examines the effects of globalization on workforce diversity and explores the approaches used by successful organizations
to foster diversity and inclusion. This research further explores the theoretical frameworks pertaining to diversity
management and employee engagement, elucidating the advantages and obstacles that businesses encounter when adopting
these strategies. The study findings indicate that enterprises must prioritize the appreciation of diversity and inclusion to
establish a secure and all-encompassing atmosphere, as well as to optimize the potential advantages that may be derived
from such practices.
Enterprise Risk Management in South African Municipalities within Legislative and Corporate Governance Frameworks
Authors: Mbunye Paulina
Published: January 2025

Risk may be described as the probability or possibility for negative consequences, such as damage, injury, loss,
or any unfavorable occurrence arising from vulnerabilities, whether they originate within or outside. These dangers may
be alleviated by preemptive steps implemented beforehand. Enterprise Risk Management (ERM) employs a comprehensive
technique to effectively identify and assess risks. The primary objective of this approach is to support decision-making
processes and improve the probability of successfully attaining strategic and analytical objectives. ERM has been widely
endorsed by several assessors, regulators, and experts as a very beneficial strategy for enterprises. This article provides an
analysis of the corporate and legislative governance structures that regulate Enterprise Risk Management in municipalities
in South Africa. This study provides a scholarly investigation into the historical progression of ERM in the public sector,
presenting a thorough examination of its adoption and execution within the governmental context of South Africa. In
addition, this statement outlines the regulatory obligations and fundamental principles of effective corporate governance
that regulate the arrangement, responsibilities, and obligations related to ERM. The report highlights the need of continuous
feedback and improvement in risk management approaches.
Upgrading Infrastructure and Communication Technologies for Organizational Success - A Comprehensive Review
Authors: Liu Adia , Eva Fabio
Published: January 2025

The use of Information and communication technology (ICT) plays a pivotal role in facilitating the operation
of the modern economy. One potential outcome of investing in and improving our country's ICT is an augmentation in
productivity. However, the impact of this phenomenon may be influenced by the level of ICT advancement and productivity
already established inside the nation, alongside the amount of investment or expenditure dedicated to ICT. Moreover, after
a designated timeframe, the utilization of ICT may potentially influence the advancement of productivity. Hence, it is
important to differentiate the temporal scope and magnitude of impact of ICT in countries characterized by high and low
levels of productivity, in order to effectively devise ICT development strategies. This article explores the significance of
investing in contemporary data storage, infrastructure, and communication technologies for firms seeking to expand their
worldwide presence. The importance of organizations allocating funds towards technological advancements, transitioning
to cloud-based infrastructure, and implementing unified communication systems is emphasized. The article further
emphasizes the significance of contemporary business technologies, like point of sale (POS, enterprise resource planning
(ERP), and customer relationship management (CRM). This paper also addresses the challenges and opportunities involved
in the formulation of an information technology globalization strategy.
The Role of Technology Incubators in Fostering Interorganizational Networks A Case Study of MaRS
Authors: Jing Gan
Published: January 2025

Business Incubators (BI) emerged in the early 1980s as a result of previous experiences with different services
aimed at developing businesses. Their main objective is to support the process of creating new ventures. They offer cost-
effective workspace along with shared amenities, counseling, training, data, and connections to external networks for
entrepreneurial collaborations. In this research, we employed a case study design to theorize on the network’s nature and
strategies of incubated firms at MaRS Innovation Centre in Canada. This research was carried out over two years (2021–
2023) in the form of 29 interviews with the representatives of the MaRS tenants, including senior executives (20) and
managers (7). The interviews that explored business development, R&D strategies and networking at MaRS were audio-
taped, transcribed, and analyzed using conventional qualitative data analysis procedures. Tenants were grouped according
to business type and incubator functions, while networks were further coded based on functions and partners. The analysis
revealed three types of networks such as advisory, spin-off, and strategic, with different degrees of engagement of support
organizations, large enterprises, and SMEs. Enablers incorporated the community setting, MaRS business services, close
access to advisers, clients, and partners, and MaRS identification, while barriers consisted of distinct business orientations,
restricted resources, numerous tenants at MaRS, and approaches to recruitment. MaRS had a strong collaborative culture
and offered a wide range of services that greatly supported network development and usage among the tenants
Impact of EPSS Supported Instruction on Ethical Decision Making and Theoretical Computer Ethics
Authors: Haldorai Anandakumar
Published: January 2025

The concept of Electronic Performance Support Systems (EPSS) has been created to refer to systems that
provide general support. This study focuses on the impacts of the BILEP system, an EPSS, on students’ learning in a
computer ethics class. Realizing that there is lack of research done on evaluating EPSS in terms of educational value in
relation to ethical decision-making skills and theoretical knowledge, this study sought to establish the effectiveness of
EPSS in improving the skills. This research employed a quasi-experimental design, which included 40 participants grouped
into the experimental group and the control group. The experimental group was taught using the newly developed BILEP
system and the control group was taught in a traditional method. Knowledge was evaluated before and after the intervention
regarding Ethical Decision Making (EDM) and Theoretical Computer Ethics (TCE). The t-tests and Mult-variate Analysis
of Variance (MANOVA) showed the significant improvement of both groups, while the experimental group demonstrated
the greater improvement in ethical decision-making skills, but not in the TCE. We concluded that practices that are
supported by EPSSs enhance ethical resolution skills, which is in line with the performance-based nature of EPSSs, and,
at the same time, traditional approaches are as effective in enhancing theoretical knowledge. Therefore, our findings
highlight the implementation of EPSS tools in ethics education to promote practical application skills.
Renovación. Boletín de ideas, libros y revistas de la América Latina. 1923-1930
Authors: Pita González Alexandra
Published: January 2025

El presente libro estudia el Boletín Renovación, órgano de La Unión Latino Americana, organización que, desde Buenos Aires, Argentina —y durante los años de 1923 a 1930—, intentó generar una red intelectual cuyo objetivo fuera integrar culturalmente a estos países. Profundiza en el análisis de la sección dedicada a la crítica de libros, revistas y folletos que se publicaron sobre América Latina en esos años porque, a través de ella, se puede señalar la circulación de un universo humano, bienes culturales (materiales) y capitales simbólicos.
Community Policing: “Atalakpa” (Edo State Security Network) and the Management of Crime and Internal Security in Edo State, Nigeria
Authors: Idowu Olusegun Oladele , Usifoh Destiny Ebatamaehi Usifoh
Published: January 2025

This study assessed the praxis of community policing in managing internal security in Edo State, Nigeria. It also evaluated the nature of community policing (Atalakpa-Edo State Security Network) in Edo State and its effectiveness. In addition, the study identified the relationship between community policing (Atalakpa-Edo State Security Network) and the public security force in Edo state.  The study further Identified the challenges confronting Atalakpa-Edo State Security Network in Edo State. The study employed survey research design, using both quantitative and qualitative research methods. Also, both primary and secondary data were explored. The data collected were analysed using descriptive statistics involving frequency counts, percentages, mean scores and charts. The findings showed that the government falls short of effectively providing security for the citizens; hence, the community opted for Atalakpa community policing, which is focused on fostering greater trust and cooperation between the police and the residents geared towards maximising police resources through community participation in public safety initiatives. The study concluded that the emergence of community policing (Atalakpa-Edo State Security Network) was borne out of the need to reduce crimes and social vices, security of lives and properties, and to complement other security agencies in fighting crime and criminality in rural areas. The study recommends restructuring and overhauling of the Atalakpa- Edo State Security Network to meet its establishment's goals and purpose. Also, there should be better collaboration and partnership between community policing and other security agencies in the area of handing-over/transporting of suspects, conducting investigation, sharing of information, fire alert, armed patrol, joint duty posting, training and re-training; workshops and seminars, with a view to fighting crime and criminality, and entrenching peace in rural areas.
Práticas sustentáveis em instituições de ensino superior: um estudo de caso na Universidade do Porto em Portugal
Authors: Battistelle Rosane Aparecida Gomes , Varum Humberto , Madeira Ana Carla Fernandes Damião , Scoton Edvaldo José
Published: January 2025

Práticas de sustentabilidade implementadas em instituições de ensino superior (IES) têm ganho destaque global com as universidades mais focadas na implementação de iniciativas sustentáveis e no desenvolvimento de políticas que visem a preservação do ambiente, ligadas aos Objetivos de Desenvolvimento Sustentável - ODS e a AGENDA 21. As várias atividades universitárias, tanto de ensino, pesquisa e extensão que ocorrem no interior de um campus universitário têm impactos positivos ao ambiente, como a minimização do consumo de água, energia e materiais. Ao se desenvolver projetos relativos à sustentabilidade, as IES assumem o compromisso de não somente formar os cidadãos nas soluções de questões técnicas e científicas, mas também capacita os alunos em decisões assertivas em pró do meio ambiente e de uma sociedade mais justa. Desta forma, este trabalho buscou examinar as iniciativas sustentáveis adotadas em universidades internacionais por meio de uma revisão sistemática da literatura acadêmica pertinente, e depois confrontá-las com as boas práticas da Universidade do Porto – UP em Portugal. Os resultados mostram que a UP implementa diversas iniciativas sustentáveis, como a coleta seletiva de resíduos, projetos de educação ambiental e parcerias com empresas para a gestão de resíduos. Essas práticas não apenas reduzem o impacto ambiental, mas também educam a comunidade acadêmica sobre a importância da sustentabilidade. Conclui-se que as práticas sustentáveis em IES são essenciais para a promoção dos ODS e a criação de uma sociedade mais consciente.
Influência do trabalho do enfermeiro, na visão do transplantado renal: á luz do Pensamento Ecossistêmico
Authors: Siqueira Hedi Crecencia Heckler de , Pedroso Vanessa Soares Mendes , Farias Letícia Cortez , Bick Miguel Armando , Paula Saul Ferraz de , Tolfo Fernando , Dutra Gelson Garcia , Dias Jennifer Specht
Published: January 2025

Objetivo: Este estudo buscou investigar como o trabalho do enfermeiro influencia o comportamento do ser humano transplantado renal à luz do Pensamento Ecossistêmico. Método: Trata-se de um estudo descritivo e exploratório, com abordagem qualitativa, realizada por meio de entrevistas semiestruturadas com 20 pacientes que realizaram transplante renal há mais de 10 anos. As entrevistas permitiram compreender as percepções e experiências dos participantes em relação ao acompanhamento de enfermagem. Resultado: Os resultados indicam que os pacientes atribuem significativa importância ao papel do enfermeiro no êxito do transplante renal, destacando tanto o suporte técnico quanto o emocional. Discussão: A análise foi conduzida sob a perspectiva do referencial ecossistêmico, que enfatiza a interação entre o indivíduo e os diversos sistemas que o cercam. A prática da enfermagem, nesse contexto, mostrou-se fundamental para promover mudanças comportamentais e reforçar a responsabilidade dos pacientes em seu próprio processo de cuidado. Considerações finais: Conclui-se que a atuação do enfermeiro, embasada no Pensamento Ecossistêmico, desempenha papel crucial no empoderamento dos pacientes e no sucesso dos transplantes renais, demonstrando a importância de um cuidado humanizado e integral.
The development of protein biscuits for pets containing pro-teinrich baru residue (Dipterix alata Vog)
Authors: Maria Zamira Abel de Jesus , Almeida Maria Carolina de , Colivet Júlio Cesar Briceno , Silva Flávio Alves da , Sá Fernando Pereira de , Caliari Márcio , Oliveira Tatianne Ferreira de
Published: January 2025

The objective of this work was to evaluate the chemical composition of by-product flours for the development of dog biscuits. 5 formulations were prepared with 0%, 5%, 10%, 15% and 20% replacement of baru by-product flours. Defatted pie flour contains high levels of protein (25.93 g 100 g-1) and lipids (24.89 g 100 g-1), but low in total fiber (6.15 g 100 g-1). Baru bark flour had low lipid (1.0 g 100 g-1) and protein (5.34 g 100 g-1) contents, but high total fiber content (59.67 g 100 g-1). The levels of total phenolic compounds vary from (14525 and 12532 mg EAG g 100 g-1) with emphasis on baru peel flour. The predominant nutrients in the cookies were carbohydrates (56.49 to 51.20 g 100 g-1 for cookies made with baru bark flour (BCB) 52.78 and 49.62 for cookies made with degreased pie flour baru (BTDB), followed by lipids (21.67-23.53 g 100 g-1 for BTDB and 19.05-22.33 g 100 g-1 for BCB) and protein (12.10-15.05 for BTDB g 100 g-1 and 11.23 and 12.19 for BCB g 100 g-1), the study highlights the importance of using by-products in the development of dog food products.
Aplicação do princípio da insignificância pelo delegado de polícia
Authors: Rego Elson Jose do , Sampaio Daniel Carvalho , Sampaio Vanessa Nunes de Barros Mendes , Nascimento Justina Alzira Soares do , Moura Enedina Gizeli Albano , Santos Jane Karla de Oliveira , Sousa Antonio Carlos Montelo , Sousa Kenneth Anderson Campos
Published: January 2025

O princípio da insignificância é um tema amplamente debatido no sistema jurídico por diversas razões. Embora não esteja explicitamente previsto na legislação brasileira, sua aplicação implica que atos criminosos que causam danos insignificantes aos bens protegidos pela lei sejam considerados atípicos. O reconhecimento desse princípio na fase policial ajuda a prevenir abusos resultantes de detenções indevidas ou processos judiciais sem justificativas adequadas. Por essa razão, surge a questão: cabe ao delegado de polícia a legitimidade para pautar suas ações com base no princípio da insignificância? Para responder a essa indagação, o objetivo geral deste estudo é analisar se o Delegado de Polícia tem autoridade para aplicar o princípio da bagatela em casos específicos, considerando seu poder discricionário. Utilizando uma metodologia integrativa bibliográfica e exploratória, o estudo foi dividido em três seções, abordando o conceito de crime, o princípio da insignificância e, por fim, uma análise mais detalhada da aplicação desse princípio pelo delegado de polícia. Os resultados revelaram duas vertentes: uma que defende a aplicação do princípio pelo delegado e outra que sustenta que esse profissional não possui competência para tal. Entretanto, a doutrina majoritária argumenta que o princípio pode ser aplicado pelo delegado, já que ele é um profissional familiarizado com a lei, e sua ação é considerada uma medida de racionalidade e eficiência na administração da justiça penal.
DÜZENLEYİCİ ÜST KURULLARIN BAĞIMSIZLIĞI
Authors: Atalar Serdar
Published: January 2025

Devletin geleneksel kurumsal gücüyle bazı kapasite sorunları yaşanması, bürokratik yapıda yavaşlık, kamusal sektörde şeffaflık ve hesap verebilirlik eksiklikleri, popülizmin varlığı ve geleneksel düzenleyici yapının yetersizliği gibi nedenlerle, hükûmetler mevcut düzenleyici yapıları yeniden yapılandırarak bankacılık, sigorta, enerji, iletişim ve tarım gibi geniş toplumsal kesimleri etkileyen bazı özel alanlarda yeni kuruluşlar kurmaktadır. Bu kuruluşlar bağımsız düzenleyici kurullar (BDK) olarak adlandırılmıştır. BDK’ların bağımsızlığı, ülkeden ülkeye, sosyal ve ekonomik faktörlere bağlı olarak farklı yorumlanmış ve uygulanmıştır. Düzenleyici bağımsızlık, hükûmet, denetlenen firmalar, tüketiciler ve kişisel menfaat sahipleri ile mesafeli bir ilişkiyi gerektirir. Uygulamada bağımsızlık sağlamak için, yapısal ve finansal bağımsızlık ile işlevsellik gibi bazı temel unsurların her düzenleyici kuruluşta bulunması gerekmektedir. Ancak bağımsızlık, mutlak bir kavram olarak değil göreceli bir kavram olarak görülmelidir; çünkü mutlak bağımsızlık ne mümkündür ne de arzu edilir ve düzenleyici otoriteler üzerinde bazı kısıtlamalar getirilmelidir. Bu bağlamda hesap verebilirlik, şeffaflık ve öngörülebilirlik uygun mekanizmalar olarak sayılabilir. Bu makalenin amacı, düzenleyici bağımsızlığın temel unsurlarını ve düzenleyici otoritenin faaliyetlerine getirilen sınırlamaları incelemektir.
Ma quanto sono nuovi i novel food?
Authors: Dameno Roberta
Published: January 2025

In Italia parlare di novel food e insetti edibili suscita ancora molta preoccupazione sia da una parte del mondo politico sia da una parte del mondo della produzione agroalimentare e più in generale da una parte dell’opinione pubblica. Due elementi contribuiscono sopra tutti a creare disinformazione e confusione. Il primo elemento deriva dal fatto che l’ordinamento giuridico dell’UE inserisce gli insetti edibili nella categoria estremamente eterogenea dei cosiddetti novel food insieme, per esempio, alla carne coltivata e ai semi di chia. Il secondo elemento deriva dal fatto che il dibattito politico, non solo in Italia, anziché soffermarsi sulla necessità di intervenire affinché sia garantito un cibo non solo di qualità, ma anche sostenibile, tratta il tema degli insetti edibili e più in generale dei novel food come una bandiera per ribadire la superiorità della cultura nazionale ed europea.
“Acciò che più fiorini che si potesse fussero ne la città di Siena per poter meglio satisfare la decta guerra”. Indagine sull’origine della monetazione aurea senese durante la dominazione viscontea (1390-1404): il fiorino di Siena detto sanese
Authors: Montagano Alessio
Published: January 2025

Il saggio, partendo dall’analisi delle fonti scritte, spiega perché la zecca di Siena ha introdotto per la prima volta nella sua storia, proprio durante il periodo della dominazione viscontea (1390-1404), un nominale aureo, smentendo quanto invece sostenuto nel passato in cui si era attribuito l’inizio della sua battitura al 1376. A sostegno di questo assunto, già avanzato per la prima volta dallo scrivente nella classificazione adottata nel volume del M.I.R. Toscana Zecche Minori[1], vengono riportate considerazioni di carattere numismatico grazie alle quali verrà proposta una definitiva successione tipologica della prima seriazione aurea senese.
Acheloo nelle monete di Neapolis: un mito moderno?
Authors: Carroccio Benedetto
Published: January 2025

Nell'ultimo secolo si è diffusa l'idea che, almeno a Neapolis, il toro dalla testa umana - frequentemente raffigurato sulle sue monete - rappresentasse Acheloios, il dio fluviale dell'Acarnania, noto per la sua battaglia con Eracle. Questa interpretazione si è basata su fonti più tarde che suggerivano che Acheloios fosse il padre della sirena Partenope, la dea eponima della città precedente a Neapolis, che secondo molti era raffigurata sul dritto di quelle monete. Tuttavia, è stato recentemente obiettato che la rappresentazione di Partenope come sirena è emersa dopo la coniazione di queste monete e che la figura femminile sulle monete, indipendentemente dal suo nome, mostra le caratteristiche iconografiche di una ninfa, la dea sovrana delle città-stato, senza il corpo alato tipico delle sirene. Inoltre, non ci sono prove di un culto dedicato ad Acheloios nella Neapolis greca. L'identificazione del toro con testa umana sulla monetazione di Neapolis sembra derivare da una modifica temporanea del tipo, avvenuta al tempo di Ermocrate in diverse zecche siciliane. Questa variante presentava una testa giovanile con piccole corna, che compariva anche su due oboli di Neapolis, accompagnata da un'iscrizione che identificava la figura come Sepethos, il fiume della città. Questa è abbinata all'immagine di una dea alata che tiene in mano un'idria, probabilmente una ninfa - forse la dea Sebethis, conosciuta attraverso le fonti letterarie.
Italian coins in medieval England after the Norman Conquest
Authors: Allen Martin
Published: January 2025

This is a survey of the use of Italian coins in medieval England from the Norman Conquest in 1066 to c. 1520. There is only one recorded find of an Italian coin in an English hoard of 1066-c. 1400, but single finds provide evidence of the limited use of a wide range of Italian coins in this period. Documentary evidence for the use of Italian gold coins in thirteenth- and fourteenth-century England is reviewed. There were two periods of extensive circulation of Venetian soldini in the early fifteenth and early sixteenth centuries.
The medieval carlino silver currency in Calabria and Basilicata in the light of three hoards in the ‘Museo Nazionale della Magna Grecia’
Authors: Baker Julian , Castrizio Daniele
Published: January 2025

In this paper the authors present three hoards, a total of 147 coins, which are preserved in the Museo Nazionale in Reggio Calabria. They were all found fortuitously in the first half of the twentieth century, and have been known for some time thanks to the writings, amongst others, of Giuseppe Procopio, Lucia Travaini, and Daniele Castrizio. In this contribution, the coins themselves are analysed in unprecedented detail according to the most recent typological bibliography. In this way, the formation processes and the final depositions and abandonments of the hoards can be formulated with greater accuracy. A picture of high-level political decision making, and of perpetual conflict affecting these areas of the Regno, during a century from the last years of the thirteenth century, emerges. The three hoards are important in terms of coin issuance, especially that in the name of Robert of Anjou at the Naples mint, the usage and circulation of these issues, and contribution they can make to the convoluted (military) history of this most southerly area of the Italian mainland.
Exchanging values: Coins, Magic, Relics and Reliquiaries
Authors: Hall Mark A.
Published: January 2025

This contribution explores the use of coins both as relics and as elements of reliquaries. The focus is medieval Europe, but comparisons are drawn with Buddhist, Islamic and Jewish practices spanning late antique to post-medieval times. It delights in acknowledging and developing the foundational contributions in this area by professor Lucia Travaini.
Monete e peste: strumenti di cura e veicolo di contagio
Authors: Perassi Claudia
Published: January 2025

Accanto alla sempre più consistente scoperta, nel corso di scavi archeologici, di sepolture basso medievali approntate per accogliere le vittime di eventi epidemici, nelle quali si rinvengono accumuli più o meno consistenti di monete, fonti scritte e archeologiche ampliano la relazione monete/peste, attribuendo alle prime un ruolo positivo e negativo nei confronti del morbo, in quanto manufatti dotati di capacità terapeutiche, ma anche in grado di trasmettere il contagio. La prima parte del contributo analizza alcune “ricette numismatiche” contro la peste, tramandate nelle opere di Gentile da Foligno, Giovanni di Rupescissa e Iacobo Soldi (XIV e XV secolo), che suggeriscono il ricorso a monete d’oro (ducati e fiorini) come ingredienti per la preparazione dell’aurum potabile. La seconda parte è, invece, focalizzata sulle cosiddette Boundary/Plague Stones inglesi, che, nel corso della Peste di Londra (1665-1666), svolsero la funzione di limite territoriale in città e villaggi afflitti dall’epidemia e di ricettacolo per le monete, che dovevano essere però sanificate, prima dell’utilizzo, con l’immersione in acqua o aceto.
Fiorini dell’elmo, della spada e del “dente”: liste monetarie in un manoscritto toscano della fine del Trecento
Authors: Pigozzo Federico
Published: January 2025

Tre liste monetarie inedite della fine del XIV secolo offrono un nuovo contributo sulla circolazione delle imitazioni dei fiorini d’oro in Francia durante il regno di Carlo V (1364-1380) e sulla monetazione aurea e argentea in Italia nella prima metà del secolo. Alcune emissioni auree francesi sono qui elencate per la prima volta nel contesto italiano. Le liste, pubblicate in appendice, mostrano altresì come gli elenchi di leghe di monete avessero una circolazione indipendente dai manuali di mercatura, nei quali molto spesso andavano a confluire.
EFFECTIVENESS OF SILODOSIN IN PATIENTS WITH MEDIAN LOBE PROJECTION OF ENLARGED PROSTATE IN TERMS OF MAXIMUM URINARY FLOW RATE (Qmax)
Authors: MAJEED Z , MEHMOOD Z , KHAN M , KHAN MA , MANAN F , KHAN R
Published: January 2025

Median lobe projection of the prostate is a distinct anatomical variation that exacerbates lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). Effective management of LUTS in these patients is critical, particularly in resource-limited settings like Pakistan. Silodosin, a highly selective α-1A adrenergic receptor antagonist, has shown promise in alleviating LUTS and improving urinary flow rates, but its efficacy in patients with median lobe projection remains underexplored. Objective: To evaluate the efficacy and safety of silodosin in improving maximum urinary flow rate (Qmax) and alleviating LUTS in patients with median lobe projection of the prostate. Methods: This prospective observational study was conducted at the Institute of Kidney Diseases, Peshawar. A total of 191 male patients aged 40–60 years with baseline Qmax ≤10 mL/sec and International Prostate Symptom Score (IPSS) ≥15 were enrolled. Patients received silodosin 8 mg once daily for four weeks. Outcomes assessed included improvements in Qmax, IPSS, and treatment-related adverse events. Data were analyzed using paired t-tests for continuous variables and Chi-square tests for categorical variables, with a p-value ≤0.05 considered statistically significant. Results: The mean baseline Qmax increased from 7.8 ± 1.2 mL/sec to 16.3 ± 2.4 mL/sec after treatment (p<0.001), with 79.6% of patients achieving a Qmax ≥15 mL/sec. The mean IPSS improved significantly from 19.6 ± 4.3 to 12.2 ± 3.1 (p<0.001), with a 50% reduction in symptoms observed in 77.5% of patients. Adverse events were minimal, with dizziness (5.2%) and nasal congestion (3.7%) being the most commonly reported. Silodosin was effective across different age groups and prostate sizes, with consistent results in patients with smaller (30–40 grams) and larger (>40 grams) prostates. Conclusion: Silodosin significantly improves urinary flow rates and alleviates LUTS in patients with median lobe projection of an enlarged prostate, with minimal adverse events. These findings support its use as an effective and safe first-line therapy in managing BPH-related LUTS in resource-limited settings like Pakistan.
CONTENT ANALYSIS OF GENDER DIFFERENCES IN SCIENTIFIC (ACADEMIC) DISCOURSE: FROM PHONETICS TO PRAGMATICS (BASED ON VIDEO LECTURES BY I. LEVONTINA AND M. KRONGAUZ)
Authors: Sargsyan R.
Published: January 2025

Gender differences in language and speech are the subject of interest in many linguistic studies. They can manifest at various levels of language: phonetic, lexical, word-formation, morphological, syntactic, pragmatic-communicative. The aim of this study is to identify differences in the speech of two lecturers (I. Levontina and M. Krongauz) at various levels of language and to understand how these differences may influence the perception and understanding of the information presented. This paper analyzes gender differences in scientific (academic) discourse based on two video lectures delivered by a man and a woman. A comprehensive approach was used in the study, covering various levels of language structure. The content analysis was conducted in three directions: speech structure analysis, linguistic analysis across language levels, analysis of pragmatics and the communicative situation. The study concludes that Russian scientific discourse, despite certain gender differences, is more or less neutral compared to everyday, advertising and other discourses. The practical significance of this study lies in the fact that its results can be used to improve communication in the scientific field, as well as for developing training and educational programs aimed at overcoming gender stereotypes in language.
MATERIALIZATION OF THE PERCEPTION OF BRAVERY AND LIBERTY BY MOVSES KHORENATSI
Authors: Khorikyan H. , Manasyan L.
Published: January 2025

In fact, the “The History of Armenia” by the “Father of Armenian History” Movses Khorenatsi can be considered a programmatic document of authentic existence, according to which in 428, after the fall of the Arshakuni kingdom, the need to restore the statehood was passed down from generation to generation. The Father of history created another important work (“Ashkharhatsoyts”-“Armenian Geography”) next to the mental and spiritual homeland, fragmented under the rule of foreigners: presenting the materialized historical territory of the Fatherland.

Indeed, the study of the immortal work “The History of Armenia” by Movses Khorenatsi is inexhaustible in various scientific aspects. Thus, we are trying to focus on one important fact — we are talking about the word քաջ— “brave” repeatedly used by the Father of history, the semantic application of which with the same content gives rise to conclusions in various information.

The patriotic historian, in addition to historical information, tried to consolidate the historical memory of his people with his work, sowing national pride in heroic ancestors. It was necessary to prepare the majority of the Armenian people under the rule of Sassanid Iran to restore independence, not to reconcile themselves to foreign rule. Accordingly, Khorenatsi inspired his people’s desire for liberty by highlighting historical figures of powerful personalities in his work.

Moreover, it is no coincidence that the Greek historian Xenophon, whose information was combined with Khorenatsi’s data, also spoke about the freedom-loving spirit of the Armenian people.
AN ATTEMPT TO ANALYZE THE EFFORTS MADE IN FOSTERING STUDENTS’ CREATIVE THINKING THROUGH THE STUDY OF FAIRY TALES
Authors: Aghababyan V.
Published: January 2025

The paper presents the process of developing students’ creative thinking can be improved through the teaching of fairy tales.

The topic was chosen taking into account the role of the fairy tale in the educational process of the growing generation, on the one hand, the limitation of professional literature on the other hand.

The methodological basis for the research is a number of educational materials related to the topic. The work can be useful for elementary school teachers, teachers of the Armenian language, students of relevant specialties of pedagogical universities. The object of the research is the process of learning the native language of elementary and middle school students. The subject of the research is the identification of the features of the development of students’ creative thinking through the study of the fairy tales covered in the textbooks of the public school. The research was carried out using a questionnaire with both open and closed questionswhich was developed by us through a combination of electronic and existing methods. A total of 30 teachers participated in the research.
ON THE PHYSICAL APPROACH TO SOLVING SOME PROBLEMS OF BYPASSING AREAS
Authors: Sargsyan S. , Nikoghosyan G. , Manukyan V.
Published: January 2025

This paper is devoted to the presentation of one physical approach to solving some problems of traversing regions encountered in combinatorics.

The paper presents a new approach based on the direct application of formulas for determining the coordinates of the center of gravity of a group of bodies.

The paper preliminarily presents the concept of the center of gravity of a set of material points, formulas for determining its coordinates, as well as two main properties/theorems possessed by the center of gravity of an arbitrary set of a finite number of bodies/material points, namely, the theorem of uniqueness of the center of gravity of a system composed of material points, and the theorem of the possibility of grouping material points. After that, the main traditional mathematical approaches used to solve some problems of traversing regions encountered in combinatorics are discussed in detail and summarized in the form of methodological guidelines. Next, a new approach to solving such problems is proposed, based on physical tools, in particular, by directly applying the formulas for determining the coordinates of the center of mass of material points. Some methodological guidelines are given for solving problems of traversing regions using the proposed physical approach. Two problems are examined, in the solution of which both well-known traditional mathematical approaches used in solving similar problems and a proposed new approach utilizing physical tools were presented.
Artificial Intelligence for Face Recognition in Security Systems: A Review of Algorithms and Challenges
Authors:   School of ICT, Faculty of Engineering, Design and Information  Communications Technology (EDICT), Bahrain Polytechnic, PO Box 33349, Isa Town, Bahrain, El-Sayed El ,   Department of Mathematics and Statistics, Faculty of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11432, Saudi Arabia., Ghorbal Anis Ben
Published: January 2025

FRT is acknowledged as one of the successful advancements of biometric applications in security, surveillance, health care and innovative solutions. More so, the past decade has seen improvements in deep learning, pre-trained Neural Network Convolutional Neural Networks (CNNs), and combining methods such as ensembles, which have highly improved the FRT's Accuracy and efficiency. Nonetheless, several issues remain – facial expression, illumination, demographic biases or adversarial and backdoor threats. Such limitations require new approaches and tools to enhance FRT's reliability and ethical use. The current review also presents ethical concerns and the social consequences of using FRT.