bluuebunny/crossref_metadata_2025 huggingface dataset:
How a Gauze Sponge Roll Enhances Surgical Exposure in Thumb Carpometacarpal Arthroplasty: A Technical Note
Authors: Holzbauer Matthias , Mihalic Julian Alexander , Gotterbarm Tobias , Froschauer Stefan Mathias
Published: October 2024

Thumb carpometacarpal arthroplasty has become a widely used standard technique in the surgical treatment of thumb carpometacarpal osteoarthritis. One of the most critical steps during this procedure is proper surgical exposure of the trapezium and the base of the first metacarpal to allow for prosthesis implantation. This article introduces a surgical technique in which a roll constructed from gauze sponges tightly wrapped with medical tape facilitates several steps in thumb carpometacarpal arthroplasty. While performing a dorsoradial approach to the thumb carpometacarpal joint, this cost-effective tool is perfectly tailored to the joint’s unique anatomy. It aids in precise hand positioning and ensures optimal exposure of the trapezium and base of the first metacarpal, which is crucial for accurate cup and stem preparation as well as for unimpeded prosthesis implantation.
Safety and Efficacy of Sodium-Glucose Transport Protein 2 Inhibitors and Glucagon-like Peptide-1 Receptor Agonists in Diabetic Kidney Transplant Recipients: Synthesis of Evidence
Authors: Bellos Ioannis , Lagiou Pagona , Benetou Vassiliki , Marinaki Smaragdi
Published: October 2024

Background: This systematic review and meta-analysis aimed to evaluate the efficacy and safety of novel antidiabetics, namely, sodium-glucose transport protein 2 inhibitors (SGLT2-i) and glucagon-like peptide-1 receptor agonists (GLP1-RA), in diabetic kidney transplant recipients. Methods: Medline, Scopus, Web of Science, CENTRAL, and Clinicaltrials.gov were systematically searched from inception until 25 August 2024. Pooled estimates were obtained by applying random-effects models. Results: Overall, 18 studies (17 observational studies and one randomized controlled trial) were included. GLP1-RA were administered to 270 and SGLT2-i to 1003 patients. After GLP1-RA therapy, patients presented significantly lower glycated hemoglobin [mean difference (MD): −0.61%; 95% confidence interval (CI): −0.99; −0.23] and body weight (MD: −3.32 kg; 95% CI: −5.04; −1.59) but a similar estimated glomerular filtration rate (eGFR) and systolic blood pressure. After SGLT2-i therapy, patients had significantly lower glycated hemoglobin (MD: −0.40%, 95% CI: −0.57; −0.23) and body weight (MD: −2.21 kg, 95% CI: −2.74; −1.67), while no difference was noted in eGFR or systolic blood pressure. Preliminary data have shown an association between SGLT2-i use and a reduced risk of cardiovascular events, graft loss, and mortality. Evidence regarding the association between GLP1-RA and SGLT2-i and proteinuria was mixed. No significant effects on calcineurin inhibitor levels were observed. The risk of urinary tract infections was similar among patients treated with SGLT2-i or placebo (odds ratio: 0.84, 95% CI: 0.43; 1.64). Conclusions: Observational data suggest that GLP1-RA and SGLT2-i administration in diabetic kidney transplant recipients may be associated with better glycemic control and reduced body weight, presenting an acceptable safety profile.
Role of Overload and Psychoemotional Variables on Health-Related Quality of Life in Informal Caregivers of People with Alzheimer’s Disease
Authors: Ferrero-Sereno Patricia , Palomo-López Patricia , Mendoza-Muñoz María , Carlos-Vivas Jorge , Urbano-Mairena Javier , Muñoz-Bermejo Laura
Published: October 2024

Background: Carers of people with Alzheimer’s disease often have a high degree of commitment and dedication which may also compromise physical and emotional, leisure, and occupational self-care. This study aimed to explore health-related quality of life (HRQoL) and psychoemotional variables in caregivers with and without caregiver overload and its relationship. Methods: A single-measure cross-sectional correlational study was carried out involving 59 informal caregivers of people with Alzheimer’s disease with a mean age of 59.30 (±10.58). The participants completed the adult HRQoL questionnaires (EQ-5D-3L), Zarit Burden Inventory test, General Happiness Questionnaire, Satisfaction with Life Scale, Rosenberg self-esteem scale, Occupational Balance Questionnaire (OBQ-E), International Fitness Scale (IFIS), Family Apgar scale, and Duke-UNC-11 Functional Social Support Questionnaire. Results: A significantly higher level of HRQoL (p = 0.029) in subjective happiness (p = 0.018), perceived social support (p = 0.046), avoidance (p = 0.034), occupational balance (p = 0.002), life satisfaction (p = 0.037), and self-perceived physical fitness (p = 0.021) was found in caregivers without perceived overload. Also, HRQoL was directly associated with self-perceived physical fitness (β = 0.534; p < 0.001) and occupational balance (β = 0.375; p < 0.001) and self-esteem (β = 0.249; p < 0.016). Conclusions: Caregivers who do not perceive overload have better levels of HRQoL and psychoemotional variables, establishing a relationship between HRQoL with self-perceived physical fitness, occupational balance, and self-esteem.
Preimplantation Genetic Testing for Aneuploidy (PGT-A) in In-Vitro Fertilisation (IVF) Treatment: Study Protocol for Pilot Phase of a Randomised Controlled Trial
Authors: Beebeejaun Yusuf , Nicolaides Kypros H. , Mania Anastasia , Sarris Ippokratis , Sunkara Sesh K.
Published: October 2024

Introduction: Poor outcomes following IVF treatments are speculated to be due to the transfer of aneuploid embryos that cannot be identified based on morphological evaluation alone. This leads to patients requiring numerous embryo transfers and, consequently, a prolonged time interval before live birth. Embryo selection following preimplantation genetic testing for aneuploidy (PGT-A) with next-generation sequencing (NGS) has been suggested as an intervention to shorten time to pregnancy in women undergoing in vitro fertilisation (IVF). Past studies assessing the clinical efficacy of PGT-A in improving clinical outcomes have been conflicting and the associated clinical pregnancy rates and live birth rates following the transfer of a mosaic embryos have yet to be determined. None of the existing studies solely included women of advanced reproductive age (ARA). The pilot study and proposed RCT will determine if, compared to morphological evaluation alone, the use of PGT-A through NGS is a more clinically effective, safer, and more cost-effective way to provide IVF treatment in women of advanced reproductive age. Method and Analysis: The proposed pilot study will aim to randomise 100 patients within a single-centre study to evaluate recruitment, randomisation, and adherence to study protocol and allocated trail arms by participating patients. The results of the pilot study will enable us to determine the sample size for a larger study to establish the effectiveness of PGT-A in ARA women. Ethics and Dissemination: The study (Integrated Research Application System Number 236067) received approval from the Health Research Authority and Health and Care Research Wales (HCRW) and the East Midlands—Leicester South Research Ethics Committee (20/EM/0290). The results will be made available to patients, the funders, the Reproductive Medicine societies, and other researchers. Trial registration: ClinicalTrials.gov Identifier: NCT05009745, n.
Assessing Preoperative (EORTC) QLQ-C30 Score in Elderly Patients with Colorectal Cancer: Results from a Prospective Cohort Study
Authors: Samara Athina A. , Diamantis Alexandros , Magouliotis Dimitrios , Tolia Maria , Tsavalas Vasileios , Tzovaras George , Tepetes Konstantinos
Published: October 2024

Background: In the present study, we aimed to investigate the association between (EORTC) QLQ-C30 scores and both preoperative somatometric parameters and postoperative outcomes in elderly patients undergoing elective surgery for resectable colorectal cancer. Methods: The 118 elderly consecutive patients who underwent colorectal surgery for cancer in a single university’s surgical department between 01/2018 and 12/2018 were prospectively enrolled in the present study. All patients with an age > 65 years, diagnosed with resectable colorectal cancer, without metastatic disease, that underwent elective surgery were included prospectively in the present study. Results: Regarding patients’ characteristics, a negative correlation between preoperative QLQ (pQLQ) score and age (p = 0.001) and a positive correlation between body mass index (BMI) and pQLQ score (p = 0.048) were observed. Furthermore, there was a statistically significant difference (p = 0.004) in the mean pQLQ score between patients with rectal or colon cancer. Moreover, assessing pQLQ score was a useful tool in terms of postoperative recovery. Negative correlations between the pQLQ score and time (days) of beginning oral feeding (p < 0.001) and length of hospital stay (p = 0.004) were found. The pQLQ score was statistically significantly lower (p = 0.005) in patients who had any postoperative complication; however, there was no difference in patients with major complications. Conclusions: Advanced age, colon cancer and decreased BMI were negatively associated with preoperative QLQ. The assessment of pQLQ in elderly patients with colorectal cancer can be a useful predictive tool for postoperative complications, length of hospital stay and postoperative rehabilitation.
Extended-Release Lithium Treatment for Adolescents with Bipolar Disorder with or Without Comorbid Autism Spectrum Disorder: Protocol of a Longitudinal Prospective Naturalistic Study for the Assessment of Efficacy and Tolerability
Authors: Sesso Gianluca , Bargnesi Francesca , Mutti Giulia , Berloffa Stefano , Viglione Valentina , Fantozzi Pamela , Tolomei Greta , Guccione Fulvio , Muratori Pietro , Milone Annarita , Masi Gabriele
Published: October 2024

Background: Lithium is the gold-standard treatment for Bipolar Disorder (BD) in both adults and adolescents, effectively managing mood episodes and reducing suicide risk. While its efficacy in neurotypical youth is well established, its use in adolescents with Autism Spectrum Disorder (ASD) and comorbid BD remains under-researched. Here, we present the protocol for a study aiming to evaluate the efficacy and tolerability of Extended-Release Lithium Salts in treating adolescents with BD and comorbid ASD compared to neurotypical BD patients. Methods: This longitudinal prospective naturalistic comparative study will enroll lithium-naïve adolescents aged 12–18 with BD, with or without comorbid ASD, from the Department of Child and Adolescent Psychiatry and Psychopharmacology. Participants will be followed for six months while receiving Extended-Release Lithium Salts treatment. Primary outcomes will include mood instability, suicidality, emotional dysregulation, and aggression, assessed through a range of clinical rating scales and diagnostic tools at baseline, three months, and six months. Secondary outcomes will focus on the safety and tolerability of Extended-Release Lithium Salts, with measures including side effect ratings, physical exams, and laboratory tests. Results: We hypothesize that Extended-Release Lithium Salts will demonstrate non-inferiority in treating BD symptoms in adolescents with comorbid ASD compared to those without ASD. Conclusions: This study is poised to fill a significant gap in the literature by providing critical data on the use of lithium for adolescents with BD and ASD. Findings will inform clinical practice and future research, potentially guiding more personalized treatment approaches for this complex and vulnerable population.
The Technologies of Electrochemical Lithium Extraction Process from Lithium-Containing Solutions
Authors: Dong Qingyuan , Gang Haiyin , Xu Jinxiao , Li Zuxiang , Wang Zhongxiang
Published: October 2024

With the rapid development of new energy vehicles and the digital electronics industry, the demand for lithium has surged, necessitating advanced lithium extraction technologies. Electrochemical methods, noted for their high selectivity and efficiency in extracting target ions from liquid sources in an environmentally friendly manner, have become increasingly vital. These methods are versatile, applicable in scenarios such as lithium extraction from saline lakes, mother liquor separation, and lithium enrichment. They include electrochemical deintercalation, electrochemical ion pumps, and electrodialysis, each offering unique benefits and challenges depending on the application context. This review provides a detailed exploration of the research progress in lithium extraction using electrochemical methods and discusses future prospects for these technologies, emphasizing their potential to meet the growing demand for lithium.
Analytical Prediction of Multi-Phase Texture in Laser Powder Bed Fusion
Authors: Huang Wei , Standish Mike , Wang Wenjia , Ning Jinqiang , Cai Linger , Gao Ruoqi , Garmestani Hamid , Liang Steven Y.
Published: October 2024

For advancing manufacturing, arising AM, with an inverse philosophical approach compared to conventional procedures, has benefits that include intricate fabrication, reduced material waste, flexible design, and more. Regardless of its potential, AM must overcome several challenges due to multi-physical processes with miscellaneous physical stimuli in diverse materials systems and situations, such as anisotropic microstructure and mechanical properties, a restricted choice of materials, defects, and high cost. Unlike conventional experimental work that requires extensive trial and error resources and FEM, which generally consumes substantial computational power, the analytical approach based on physics is an exceptional choice. Understanding the relationship between the microstructure and material properties of the fabricated parts is a crucial focus in AM research. Texture is a vital factor in almost every modern industry. This study first proposed a physics-based model to foreshadow the multi-phase crystallographic orientation distribution in Ti-6Al-4V LPBF while considering the part boundary conditions due to the importance of part geometry in real industry. The thermal distribution obtained from this function operates as the information for the single-phase crystallographic texture model. In this model, we forerun and validate the orientations of single-phase materials utilizing three Euler Angles with the principles of CET and thermodynamics, as well as the intensity of the texture by approximating them with published results. Then, we transform the single-phase texture into a dual-phase texture in Bunge calculation, illustrating visualized by pole figures of both BCC and HCP phases. The tendency and appearances of both BCC and HCP phases in pole figures predicted agree well with the experimental results. This texture evolution model provides a new paradigm for future researchers to model the texture or microstructure evolution semi-analytically and save many computational resources in a real-world perspective. Others have not yet done this work about simulating the multi-phase texture in an analytical approach, so this work bridges the gap in this field. Furthermore, this paper establishes the foundation for future research on materials properties affected by microstructure or texture in academic and industrial environments. The precision and dependability of the results obtained through this method make it a valuable tool for ongoing research and advancement.
Multi-Objective Optimization Design of a Mooring System Based on the Surrogate Model
Authors: Ye Xiangji , Zheng Peizi , Qiao Dongsheng , Zhao Xin , Zhou Yichen , Wang Li
Published: October 2024

As the development of floating offshore wind turbines (FOWTs) progresses from offshore to deeper sea, the demands on mooring systems to ensure the safety of the structure have become increasingly stringent, leading to a concomitant rise in costs. A parameter optimization method for the mooring system of FOWTs is proposed, with the mooring line length and anchor radial spacing as the optimization variables, and the minimization of surge, yaw, and nacelle acceleration as the objectives. A series of mooring system configuration samples are generated by the fully analytical factorial design method, and the open source program OpenFAST is employed to simulate the global responses in the time domain. To enhance the efficiency of the optimization process, a multi-objective evolutionary algorithm, Non-dominated Sorting Genetic Algorithm II (NSGA-II), is utilized to find the Pareto-optimal solutions, alongside a Kriging model, which serves as a surrogate model for the FOWTs. This approach was applied to an IEC 15MW FOWT to demonstrate the optimization procedure. The results indicate that the integration of the genetic algorithm and the surrogate model achieved rapid convergence and high accuracy. Through this optimization process, the longitudinal motion response of FOWTs is reduced by a maximum of 6.46%, the yaw motion by 2.87%, and the nacelle acceleration by 11.55%.
Global Responses Analysis of Submerged Floating Tunnel Considering Hydroelasticity Effects
Authors: Ye Xiangji , Zhou Xiangbo , Wang Ming , Qiao Dongsheng , Zhao Xin , Wang Li
Published: October 2024

To investigate the applicability and differences in wave loads and the dynamic response calculation principles for SFT on an entire-length scale, two numerical models of entire-length SFT with identical dimensions and parameters were established. These models are employed by a 3D diffraction method based on rigid-body assumptions, the potential flow theory and the Dummy-Connection-Mass (DCM) method based on the lumped mass method and Morison equation while considering hydroelasticity effects. The applicability of the potential flow theory and Morison equation for wave load calculation of SFT is presented along with the differences in their dynamic response calculation, which aim to explore the impact on SFT dynamic responses considering hydroelasticity by comparing the numerical calculation results. Furthermore, a comparison between free-end boundary and fixed-end boundary models, established using the DCM method, is conducted to examine the reasonableness of the commonly adopted free-end boundary condition.
Mitigating Genotype–Environment Interaction Effects in a Genetic Improvement Program for Liptopenaeus vannamei
Authors: Huong Tran Thi Mai , Hung Nguyen Huu , Ty Vu Dinh , Tru Dinh Cong , Nguyen Nguyen Hong
Published: October 2024

The genotype-by-environment interaction (G × E) might have crucial impacts on the performance and fitness of agricultural species, such as Pacific whiteleg shrimp (Litopenaeus vannamei). This study explores how enhancements in management practices can counteract G × E effects on growth traits. We analyzed a selectively bred population of whiteleg shrimp spanning the latest two generations, encompassing 259 full-sib and half-sib families with 40,862 individual shrimp, measured for body weight and total length. Our analysis revealed moderate genetic correlations (0.60–0.65) between trait expressions in pond and tank environments, a significant improvement compared to earlier generations. Employing the average information-restricted maximum likelihood (REML) approach in mixed model analysis showed significant differences in heritability (h2) estimates between the two environments; however, the extent of these differences varied by trait (h2 = 0.68 in pond vs. 0.37 in tank for weight, and 0.41 vs. 0.67 for length). Our results indicate that G × E effects on growth traits in this population of L. vannamei were moderate but biologically significant. Consistent with our previous estimates in this population, genetic correlations between body weight and total length remained high (close to one) in pond and tank environments. The present findings collectively demonstrate that management improvements targeting stocking density, aeration, water quality, feeds, and feeding regimes mitigated the G × E effects on two economically significant traits in this population of whiteleg shrimp.
Research on the Hydrodynamic Characteristics of a Rectangular Otter Board in Different Work Postures Based on a Dynamic Model
Authors: Chu Wenhua , Zhai Minghao , Cui Senqi , Cao Yu , Zhang Xinyang , Zhou Qiaoli
Published: October 2024

This paper investigates the hydrodynamic characteristics of a rectangular otter board in different working postures by using a dynamic model. Dynamic models are mainly based on dynamic mesh techniques. The results of the dynamic model are, compared to the model test, carried out in a flume tank. Furthermore, different rotation speeds of dynamic model were analyzed. The research results are as follows: compared to flume tank results, the maximum error of the dynamic model is 23.77%. Moreover, the influence of rotation speed on the hydrodynamic board is not obvious, and 2 deg./s was chosen as the rotation speed. When the board is tilted slightly (including four working postures), its lift-to-drag ratio first increases slightly and then gradually decreases. Compared with the other three working postures, the pressure center coefficient of the board does not change significantly when it is tilted inward. When studying different working angles (including AOA and tilt angle) of the otter board, the numerical dynamic model significantly reduces repetitive setup work, making simulations more efficient. Its ability to provide continuous curves and a large volume of results offers researchers a more detailed and comprehensive understanding of the board’s hydrodynamics. Additionally, the dynamic model supports innovative fishery equipment development by allowing more accurate and continuous numerical simulations.
Graph Matching for Underwater Simultaneous Localization and Mapping Using Multibeam Sonar Imaging
Authors: Zhuang Lingfei , Chen Xiaofeng , Lu Wenjie , Yan Yiting
Published: October 2024

This paper addresses the challenges of underwater Simultaneous Localization and Mapping (SLAM) using multibeam sonar imaging. The widely used Iterative Closest Point (ICP) often falls into local optima due to non-convexity and the lack of features for correct registration. To overcome this, we propose a novel registration algorithm based on Gaussian clustering and Graph Matching with maximal cliques. The proposed approach enhances feature-matching accuracy and robustness in complex underwater environments. Inertial measurements and velocity estimates are also fused for global state estimation. Comprehensive tests in simulated and real-world underwater environments have demonstrated that the proposed registration method effectively addresses the issue of the ICP algorithm easily falling into local optima while also exhibiting excellent inter-frame registration performance and robustness.
Bollard Pull and Self-Propulsion Performance of a Waterjet Propelled Tracked Amphibian
Authors: Kim Taehyung , Yoon Donghyeon , Seo Jeongil , Wang Jihyeun
Published: October 2024

This paper describes the unique full-scale bollard pull and self-propulsion tests of a large amphibious tracked military vehicle with two waterjet propulsors. To provide a reference for the self-propulsion and cavitation performance, a series of sea trials and bollard pull tests were performed in a military sea bay and in a large test basin, respectively. Good overall agreement between the sea trial and the computation was observed in the speed–power relationship. The cavitation-induced breakdown phenomenon was further explored via numerical simulations. The results indicated that the uncertainties in the numerical results were dominated by the scales of vapor bubbles. The analysis showed that the selection of the vapor bubble scale factors of 1.0 for growth and 0.05 for collapse were in good agreement with the experimental results. Rapid performance breakdown occurred when sufficient suction side-attached cavities were extended into the blade mid-chord and tip-board regions.
An Overview of Probabilistic Safety Assessment for Nuclear Safety: What Has Been Done, and Where Do We Go from Here?
Authors: Lye Adolphus , Chang Jathniel , Xiao Sicong , Chung Keng Yeow
Published: October 2024

The paper provides an introduction to the concept of Probabilistic Safety Assessment, an evaluation of its recent developments, and perspectives on the future research directions in this area. To do so, a conceptual understanding to safety assessment is first provided, followed by an introduction to what Probabilistic Safety Assessment is about. From this, the historical background and development of Probabilistic Safety Assessment in the context of nuclear safety are discussed, including a brief description and evaluation of some methods implemented to perform such analysis. After this, the paper reviews some of the recent research developments in Probabilistic Safety Assessment in the aspects of multi-unit safety assessment, dynamic Probabilistic Safety Assessment, reliability analysis, cyber-security, and policy-making. Each aspect is elaborated in detail, with perspectives provided on its potential limitations. Finally, the paper discusses research topics in six areas and challenges within the Probabilistic Safety Assessment discipline, for which further investigation might be conducted in the future. Hence, the objectives of the review paper are (1) to serve as a tutorial for readers who are new to the concept of Probabilistic Safety Assessment; (2) to provide a historical perspective on the development of the Probabilistic Safety Assessment field over the past seven decades; (3) to review the state-of-the-art developments in the use of Probabilistic Safety Assessment in the context of nuclear safety; (4) to provide an evaluative perspective on the methods implemented for Probabilistic Safety Assessment within the current literature; and (5) to provide perspectives on the future research directions that can potentially be explored, thereby also targeting the wider research community within the nuclear safety discipline towards pushing the frontiers of Probabilistic Safety Assessment research.
Tuning into Fairness? Comparative Content Analysis of Discrimination Reporting in Flemish Public and Commercial Television News
Authors: De Nolf Ans , Steeman Lise-Lore , De Cock Rozane , d’Haenens Leen
Published: October 2024

Disadvantaged groups often face negative portrayals in the media, particularly in news outlets. These portrayals lead to misrepresentation, misunderstanding, and perpetuation of harmful stereotypes. Adding insult to injury, issues important to these groups, such as discrimination, are often reported with bias. Furthermore, media outlets present discrimination discourse differently, evolving from general to specific issues over time. Television news, a primary information source for 76% of Flemish households significantly shapes public perceptions. Therefore, examining television news portrayal of discrimination is crucial, as it can either reinforce or challenge existing prejudices. This longitudinal study analyzes Flemish television news coverage of discrimination (N = 252) from 2017 to 2021, comparing the public broadcaster VRT with its commercial counterpart VTM. Racial discrimination was the most frequently reported issue, influenced by global movements like Black Lives Matter (BLM). There was an increase in coverage of sexuality-related discrimination in 2021, reflecting heightened media focus on LGBTQ+ issues and activism. The portrayal of discrimination varied, with direct discrimination most frequently reported. While VRT and VTM differed significantly in coverage duration and focus, overall coverage of discrimination topics showed no major disparities. This study emphasizes the need to address intersectionality and systemic issues in media coverage to reflect societal diversity accurately.
Network Pharmacology Approaches Used to Identify Therapeutic Molecules for Chronic Venous Disease Based on Potential miRNA Biomarkers
Authors: Barrera-Vázquez Oscar Salvador , Escobar-Ramírez Juan Luis , Magos-Guerrero Gil Alfonso
Published: October 2024

Chronic venous disease (CVD) is a prevalent condition in adults, significantly affecting the global elderly population, with a higher incidence in women than in men. The modulation of gene expression through microRNA (miRNA) partly regulated the development of cardiovascular disease (CVD). Previous research identified a functional analysis of seven genes (CDS2, HDAC5, PPP6R2, PRRC2B, TBC1D22A, WNK1, and PABPC3) as targets of miRNAs related to CVD. In this context, miRNAs emerge as essential candidates for CVD diagnosis, representing novel molecular and biological knowledge. This work aims to identify, by network analysis, the miRNAs involved in CVD as potential biomarkers, either by interacting with small molecules such as toxins and pollutants or by searching for new drugs. Our study shows an updated landscape of the signaling pathways involving miRNAs in CVD pathology. This latest research includes data found through experimental tests and uses predictions to propose both miRNAs and genes as potential biomarkers to develop diagnostic and therapeutic methods for the early detection of CVD in the clinical setting. In addition, our pharmacological network analysis has, for the first time, shown how to use these potential biomarkers to find small molecules that may regulate them. Between the small molecules in this research, toxins, pollutants, and drugs showed outstanding interactions with these miRNAs. One of them, hesperidin, a widely prescribed drug for treating CVD and modulating the gene expression associated with CVD, was used as a reference for searching for new molecules that may interact with miRNAs involved in CVD. Among the drugs that exhibit the same miRNA expression profile as hesperidin, potential candidates include desoximetasone, curcumin, flurandrenolide, trifluridine, fludrocortisone, diflorasone, gemcitabine, floxuridine, and reversine. Further investigation of these drugs is essential to improve the treatment of cardiovascular disease. Additionally, supporting the clinical use of miRNAs as biomarkers for diagnosing and predicting CVD is crucial.
The Cryptocurrencies in Emerging Markets: Enhancing Financial Inclusion and Economic Empowerment
Authors: El Hajj Mohammad , Farran Imad
Published: October 2024

The present study discusses how adopting cryptos affects financial inclusion in developing economies. Primary constructs like financial inclusion (FI), perceived economic empowerment (PEE), trust in financial institutions (TFI), user satisfaction (US), and cryptocurrency adoption (CA) were tested through Structural Equation Modeling (SEM). The results indicated that CA significantly and positively influenced FI, US, TFI, and PEE. These relationships extend to the interaction effects: US, TFI, and PEE, all positively related to FI. This is a reflection of cryptocurrencies as an opportunity to redress most of the afflictions characteristic of traditional finance systems and to promote financial inclusion and economic empowerment in developing countries. Future research should also investigate whether digital literacy and regulatory environments support cryptocurrency access.
Digital Financial Literacy and Its Impact on Financial Decision-Making of Women: Evidence from India
Authors: Mishra Deepak , Agarwal Naveen , Sharahiley Sanawi , Kandpal Vinay
Published: October 2024

Despite the increasing accessibility of digital financial instruments globally, a number of women encounter obstacles in properly using these platforms due to insufficient digital financial literacy, which profoundly affects their financial decision-making and economic empowerment. This study aims to promote digital financial literacy and Fintech adoption for women in India by examining the effects of digital financial literacy on financial decision-making while considering the mediating effect of government support and digital financial literacy. Furthermore, in this study, we analyzed the relationship between independent variables such as financial attitude (FAtt), subjective norms (SNs), perceived behavior control (PBC), digital financial literacy (DFL), and financial accessibility (FA) on the dependent variable, i.e., financial decision-making (FDM). We also explored how financial decision-making impacts women’ intention towards investment (INT). By analyzing 385 Indian women respondents using Structural Equation Modeling (SEM), this study revealed that financial attitude (FAtt) leads to higher financial decision-making (FDM), exerting moderate effects. Similarly, subjective norms (SNs), perceived behavioral control (PBC), digital financial literacy (DFL), and financial accessibility (FA) significantly lead to financial decision-making. Overall, the five predictors of financial decision-making explained around 71% of the variance. Financial decision-making exerted a significant and robust effect on women’s intention towards investment. Financial resilience significantly moderated the effects of financial decision-making on women’s intention towards investment. These findings emphasize the necessity of implementing a distinct government strategy and programs to enhance the adoption of Fintech among women living in urban and rural regions across India. This study is aligned with UN Sustainable Development Goals, especially Sustainable Development Goal (SDG) 1: No Poverty, SDG 5: Gender Equality, and SDG 8: Decent Work and Economic Growth.
Knowledge Atlas of Cultivated Land Quality Evaluation Based on Web of Science Since the 21st Century (2000–2023)
Authors: Xue Pingluo , Shen Chongyang , Tang Huaizhi , Liu Yunjia , Huang Yuanfang
Published: October 2024

Cultivated land is the most important natural resource for human survival and development. The quality of cultivated land is closely related to grain output, and whether it can guarantee stable food supply is directly related to national food security. Cultivated land quality evaluation is an effective tool for understanding and mastering cultivated land quality. However, few studies have applied bibliometrics to quantitatively and systematically analyze this field. We used VOSviewer 1.6.19 and CiteSpace 6.3.1 software to visually analyze and construct 2478 documents related to cultivated land quality evaluation retrieved from the Web of Science core collection database from 2000 to 2023. Results show that cultivated land quality evaluation is still a popular research field. The collaboration ability among authors is weak and the distribution of institutions and countries publishing in this field is very uneven. In addition, the relevant research has been published in a variety of journals such as agriculture, environment, ecology, and computer technology. The research content is becoming more and more interdisciplinary. Keywords such as “Soil quality”, “Swat”, “Remote sensing”, “Heavy metals” and “Ecosystem services” have become hot topics in this field. In the future, it is necessary to further deepen the connotation of cultivated land quality, develop a long time series dynamic model of cultivated land quality evaluation and monitoring, and enhance the transformation of research results into practical applications.
Perioperative and Long-Term Outcomes After Combined Liver and Kidney Transplantation: A Single-Center Experience
Authors: Cerović Kosta , Hadžialjević Benjamin , Hawlina Simon , Trotovšek Blaž
Published: October 2024

Combined liver–kidney transplantation (CLKT) has evolved as a therapeutic option for patients with concurrent end-stage liver and renal diseases. This study evaluates the perioperative and long-term outcomes of CLKT at a single center in Slovenia, highlighting the challenges and successes of simultaneous organ transplantation. We retrospectively analyzed all patients undergoing simultaneous CLKT at the University Medical Centre Ljubljana from April 2014 to June 2023. Data on demographics, cause of liver and kidney disease, operative details, postoperative complications, patient and graft survival, and follow-up were collected and analyzed. Five patients aged 27 to 60 years underwent CLKT within the study period. All transplants involved deceased donors with whole-liver grafts. Indications for CLKT were polycystic liver disease (n = 3), Caroli’s disease (n = 1), and alcoholic cirrhosis (n = 1). The mean follow-up duration was 45.2 months, with a 100% survival rate. The incidence of surgical and postoperative complications was low. This pioneering series of simultaneous CLKTs in Slovenia demonstrates the feasibility and effectiveness of the procedure in smaller transplant centers. Despite challenges, including T cell-mediated kidney rejection and surgical complications, the study emphasizes the importance of comprehensive postoperative care and management in optimizing outcomes for CLKT recipients.
Selection and Effect of Plant Growth-Promoting Bacteria on Pine Seedlings (Pinus montezumae and Pinus patula)
Authors: Moreno-Valencia Francisco David , Plascencia-Espinosa Miguel Ángel , Morales-García Yolanda Elizabeth , Muñoz-Rojas Jesús
Published: October 2024

Forest cover is deteriorating rapidly due to anthropogenic causes, making its restoration urgent. Plant growth-promoting bacteria (PGPB) could offer a viable solution to ensure successful reforestation efforts. This study aimed to select bacterial strains with mechanisms that promote plant growth and enhance seedling development. The bacterial strains used in this study were isolated from the rhizosphere and endophyte regions of Pinus montezumae Lamb. and Pinus patula Schl. et Cham., two Mexican conifer species commonly used for reforestation purposes. Sixteen bacterial strains were selected for their ability to produce auxins, chitinase, and siderophores, perform nitrogen fixation, and solubilize inorganic phosphates; they also harbored genes encoding antimicrobial production and ACC deaminase. The adhesion to seeds, germination rate, and seedling response of P. montezumae and P. patula were performed following inoculation with 10 bacterial strains exhibiting high plant growth-promoting potential. Some strains demonstrated the capacity to enhance seedling growth. The selected strains were taxonomically characterized and belonged to the genus Serratia, Buttiauxella, and Bacillus. These strains exhibited at least two mechanisms of action, including the production of indole-3-acetic acid, biological nitrogen fixation, and phosphate solubilization, and could serve as potential alternatives for the reforestation of affected areas.
The Outcomes of Adult Acquired Buried Penis Surgical Reconstruction
Authors: Falcone Marco , Plamadeala Natalia , Cirigliano Lorenzo , Preto Mirko , Peretti Federica , Ferro Ilaria , Scavone Martina , Zupo Emanuele , Gontero Paolo
Published: October 2024

Adult Acquired Buried Penis (AABP) is a morbid condition that often requires surgical intervention. This retrospective study of 46 patients who underwent AABP surgery from November 2017 to July 2023 evaluates surgical outcomes, functional outcomes, and patient-reported outcomes. The median follow-up (FU) was 46 months. Patients were categorized by surgical complexity using the Pariser classification, with 76.1% undergoing high-complexity procedures (Pariser ≥ III). Common comorbidities included obesity (58.7%), prior circumcision (52.2%), and hypertension (52.2%). The low-complexity group had a shorter hospital stay (p = 0.02). No other significant differences were noted between groups in terms of Body Mass Index, operative time, or FU. Sexual dysfunction (45.7%) and urinary issues (38.1%) were the main reasons for surgical consultation. Skin grafting was required in 63.0% of patients; partial graft loss was more common in full thicknes skin graft group (p = 0.04). Postoperative complications occurred in 32.6% of patients, 13.3% of which were classified severe (Clavien ≥ III). The median increase in stretched penile length was 2 cm. The recurrence rate was 21.7%. The 12-month recurrence-free survival rate was 89.1%. All groups saw significant improvements in urinary and sexual function post-surgery (p < 0.05), and high patient satisfaction was reported (90.3%). Despite the complication rate, AABP surgery significantly improves quality of life, with ongoing advancements in technique anticipated to enhance outcomes further.
Dam Impact on Fish Assemblages Associated with Macrophytes in Natural and Regulated Floodplains of Pandeiros River Basin
Authors: Prado Ivo Gavião , Souza Marcela Alves de , Coelho Flávia Freitas , Pompeu Paulo Santos
Published: October 2024

The impacts of hydropower plants and their reservoirs on floodplains can potentially create new environmental filters and reduce the exchange of organisms and access to habitats. In this study, we aimed to compare the fish assemblage associated with aquatic macrophytes between floodplain lakes under natural conditions and a regulated floodplain lake in the Environmental Protection Area of Rio Pandeiros, Brazil. We tested the hypothesis that in the regulated floodplain lake, there would be a lower richness and a greater of abundance of macrophytes and fish than is natural. We also verified the influence of the seasons, macrophyte bank richness, and biomass on the fish assemblage abundance. The fish assemblages differed between the regulated and natural floodplains due to the higher richness and abundance of fish in the natural floodplains. The presence of non-native and generalist species in the regulated floodplain influenced the dissimilarity between the floodplains. Migratory species have been found only in natural floodplains. Fish abundance was negatively related to macrophyte richness on the regulated lake. There was a lower fish abundance and macrophyte richness in the regulated lake. There was no evidence that macrophyte biomass affected the abundance and richness of fishes. Our results confirm that the Pandeiros small hydroelectric dam affects the fishes’ assemblage and the macrophyte community, since the regulated floodplain lake has a lower richness and abundance of fish. The regulated floodplain lake is connected to a reservoir created by a small hydroelectric dam, which will be removed in the coming years. The removal of this dam might change these dynamics, and this must be evaluated when the change is implemented.
Metabolic Syndrome, Hepatic Steatosis and Testosterone: A Matter of Sex
Authors: Gangitano Elena , Scannapieco Francesca , Lubrano Carla , Gnessi Lucio
Published: October 2024

Hepatic steatosis is considered the hepatic manifestation of metabolic disorders. Its global prevalence is a growing public health concern, estimated to affect over 30% of the population. Steatosis is strictly linked to metabolic dysfunction, leading to the revised terminology of MASLD (metabolic dysfunction-associated steatotic liver disease). The disease often progresses in conjunction with metabolic syndrome components, significantly increasing cardiovascular and overall mortality risks. The interplay between sex hormones and metabolic dysfunction is crucial, with male hypogonadism and female hyperandrogenism exacerbating the risk and severity of hepatic steatosis. In men, testosterone deficiency is associated with increased visceral adiposity and insulin resistance, creating a vicious cycle of metabolic deterioration. Conversely, in women, hyperandrogenism, particularly in conditions like polycystic ovary syndrome, may lead to severe metabolic disturbances, including hepatic steatosis. Estrogen deficiency also contributes to central adiposity and metabolic syndrome. The aim of this paper is to discuss this complex sex-dimorphic relationship.
Effect of Thermal Load Caused by Tread Braking on Crack Propagation in Railway Wheels on Long Downhill Ramps
Authors: Zhang Jinyu , Chen Xun , Tao Gongquan , Wen Zefeng
Published: October 2024

To investigate the propagation behavior of thermal cracks on the wheel tread under the conditions of long downhill ramps, a three-dimensional finite element model of a 1/16 wheel, including an initial thermal crack, was developed using the finite element software ANSYS 17.0. The loading scenarios considered include mechanical wheel–rail loads, both with and without the superposition of thermal wheel–brake shoe friction loads. The virtual crack closure method (VCCM) is employed to analyze the variations in stress intensity factors (SIFs) for Modes I, II, and III (KI, KII, and KIII) at the 0°, mid, and 90° positions along the crack tip. The simulation results show that temperature is a critical factor for the propagation of thermal cracks. Among the SIFs, KII (Mode II) is larger than KI (Mode I) and KIII (Mode III). Specifically, the thermal load on the wheel tread during braking contributes up to 23.83% to KII when the wheel tread reaches the martensitic phase transition temperature due to brake failure. These results are consistent with the observed radial propagation of thermal cracks in wheel treads under operational conditions.
Ac-[K-Aib-C(3,9-Acm; 6,12-SSNC(Acm)QENSDK)]4-NH2
Authors: Moulasioti Vasiliki , Fotou Evgenia , Moussis Vassilios , Tsikaris Vassilios
Published: October 2024

Advances in synthetic peptide methodologies have enabled the development of macromolecules mimicking protein properties and have found applications in various fields, particularly in immunology. Furthermore, Sequential Oligopeptide Carriers (SOCn and CPSOC) have been designed as multi-functional core molecules, to which multiple bio-cargos can be anchored, allowing the construction of high molecular weight molecules (>3000 Da) capable of inducing a strong immune response. This study presents the design and synthesis of the Ac-[K-Aib-C(3,9-Acm; 6,12-SSNC(Acm)QENSDK)]4-NH2 peptide conjugate of branched architecture. The peptide epitope S128SNCQENSDK137 belongs to the V. berus basic phospholipase A2, a member of the European viper species’ most lethal protein families. The peptide epitope was synthesized according to the SPPS Fmoc/tBu strategy and characterized by HR-ESI-MS and NMR experiments, while the conjugate was purified by RP-HPLC and characterized by HR-ESI-MS.
Facile One-Pot Synthesis of Fe3O4 Nanoparticles Composited with Reduced Graphene Oxide as Fast-Chargeable Anode Material for Lithium-Ion Batteries
Authors: Seong Honggyu , Jung Taejung , Kim Sanghyeon , Choi Jaewon
Published: October 2024

To address the rapidly growing demand for high performance of lithium-ion batteries (LIBs), the development of high-capacity anode materials should focus on the practical perspective of a facile synthetic process. In this work, iron oxide nanoparticles (Fe3O4 NPs) in situ grown on the surface of reduced graphene oxide (rGO), denoted as Fe3O4 NPs@rGO, were prepared through a facile one-pot synthesis under the wet-colloidal conditions. The synthesized Fe3O4 NPs showed that uniform Fe3O4 NPs, with a size of around 9 nm, were distributed on the rGO surfaces. When applied as an anode material for LIBs, the Fe3O4 NPs@rGO anode revealed a high reversible capacity of 1191 mAh g−1 at 1.0 A g−1 after 200 cycles. It also exhibited excellent rate performance, achieving 608 mAh g−1 at a current density of 5.0 A g−1 over 500 cycles, with improved electronic and ionic conductivities due to the rGO template. This suggested that practically available anode materials can be developed through our one-pot synthesis by in situ growing the Fe3O4 NPs.