bluuebunny/crossref_metadata_2025 huggingface dataset:
Production of a new variant of soluble trimer Env of HIV-1 CRF63_02A6 SOSIP.664
Authors: Rudometova Nadezhda B. , Rudometov Andrey P. , Fando Anastasia A. , Vahitov Danil I. , Ilyichev Alexander A. , Agafonov Alexander P. , Karpenko Larisa I.
Published: November 2024

Introduction. Obtaining stabilized recombinant HIV-1 Env trimers that have a close to the native conformation is one of the directions in the field of development of vaccines against HIV-1.
The aim of the study was to obtain and characterize the stabilized trimer Env of HIV-1 SOSIP.664 based on the circulating genetic variant of the recombinant form CRF63_02A6.
Materials and methods. Bioinformatics resources were used to design the trimer Env gene based on the HIV-1 recombinant genetic variant CRF63_02A6. The designed gene was synthesized and cloned as part of an integration plasmid vector. A stable producer of trimer Env was obtained by transfection of the CHO-K1 cell line using the developed plasmid vector. Purification of the protein complex was performed using affinity chromatography and gel filtration. Antigenic properties of trimer Env were studied using immunochemical analysis using broadly neutralizing HIV-1 monoclonal antibodies (bnAbs).
Results. A new variant of the stabilized trimer Env of the surface glycoprotein of the recombinant form CRF63_02A6 HIV-1 SOSIP.664 was designed, including additional stabilizing modifications. Based on the CHO-K1 cell line, a stable producer was obtained and a purification protocol for the designed trimer Env was developed. It was found that the trimer Env CRF63_02A6 SOSIP.664 is effectively recognized by bnAbs 2G12, VRC01 and PGT126.
Conclusion. The obtained results indicate the prospects for further study of the structural features of the trimer Env CRF63_02A6 SOSIP.664, as well as its immunogenicity and the possibility of using it as a vaccine antigen.
Serum Calcium, Phosphate and Parathormone Levels in Thalassemic Children with High Ferritin Level
Authors: Glory Dr. Pandora , Hossain Dr. Md. Al Mamun , Sarmin Dr. Zannat-ul- , Hena Dr. Mst. Hasna , Kabir Dr. Farzana , Sultana Dr. Afroza
Published: November 2024

Background: In thalassemic children with high ferritin level due to iron accumulation in parathyroid gland may developed hypoparathyroidism leading to impaired homeostasis of calcium & phosphate. Parathyroid dysfunctions may not be evident clinically in early state. So the parathyroid status should be evaluated at regular interval. Objective: To find out the association of serum calcium, phosphate and parathormone levels in thalassemic children with high serum ferritin level. Materials and methods: The study was a cross-sectional study carried out in Department of Paeditarics, Dhaka Medical College Hospital, Dhaka, Bangladesh during January, 2019 to December, 2019. Total 70 thalassemia patients both male &female were included in this study between the age ranged from 5 to 12 years with serum ferritin level >1000 ng/ml irrespective of chelation therapy. All study subjects were fully evaluated clinically, thoroughly investigated and properly treated as per protocol. Results: Total 70 patients were included in our study. Male were 39 (55.7%) and female were 31(44.3%). S. Calcium level was decrease in 22(31.4%) patient, S PO4 level increased in 44 (62.9%) patients & parathyroid level was low in 16 (22.9%) patients. Conclusion: Based on result it could be concluded that thalassemic children age ranged from 5 years to 12 years, presenting with high ferritin level are likely to have low calcium, high phosphate & low parathormone level.
Quadrotor Trajectories Optimisation using Metaheuristic Algorithm in Python
Authors: Mahamat Oumar Abderamane , Hassan Dr Mahamat Issa
Published: November 2024

Quadrotors, known for their agility and ability to perform intricate manoeuvres, have become increasingly popular in the last decade. Precisely tracking complex flight paths has been a major research focus. While trajectory optimization offers a continuous search space and allows for utilizing problem-specific knowledge, its reliance on local optimization methods necessitates a global planner for generating feasible trajectories from arbitrary starting points to goals. Designing such trajectories for quadrotors, with their five degrees of freedom and intricate dynamic constraints (e.g., limitations on state variables), presents a significant challenge. Existing global planners struggle to solve these trajectory generation problems for complex dynamical systems in a practical timeframe. This paper explores the use of metaheuristic optimization for planning quadrotor flight trajectories, specifically focusing on the FSA and FSASCA algorithms. These methods have demonstrated promising results in specific scenarios, but their performance depends heavily on the application and its constraints. The paper emphasizes a trade-off between solution quality and execution speed: seeking faster execution may require sacrificing solution quality, while prioritizing optimality may lead to longer execution times.
The research clinical and instrumental methods of examination of athletes related to the process of intervertebral disk degeneration and stenosis
Authors: Tyshchenko Valeria , Ksenzov Tymur , Odynets Tetiana , Bogoslav Tetiana , Ksenzov Artur , Hlukhov Ivan , Drobot Kateryna
Published: November 2024

Aim

To determine the level structure of the graph model of the system of clinical and instrumental indicators of athletes with herniated intervertebral discs complicated by spinal stenosis, and to determine the regression model for these indicators.

Material and methods

This observational study involved 64 athletes (14 – rugby players, 16 – handball players, 15 – basketball players, 19 – football players) with intervertebral disc herniation, complicated by stenosis of spinal canal. Research methods: visual method to evaluate the likelihood of a data set's normal distribution; correlation and regression analysis; method for determining the ordinal function of a graph through the application of an adjacency matrix, specifically utilizing Demucron's algorithm. This process is accompanied using a topological sorting of the graph.

Results

The results showed the lack of correlation between age and VAS, muscle strength and VAS, as well as VAS and the channel space; little feedback between age and the channel space; weak positive relationship between size of herniated intervertebral disc had a with the length of the illness. The data showed, strong feedback was observed for hernia size and the channel space, hernia size and muscle strength, the channel space, and length of the illness.

Conclusions

The evaluation on the complexity and depth of the interconnections between clinical and instrumental metrics in athletes was conducted. The hierarchical organization within the graphical representation was ascertained. A predictive regression model delineating the correlations between clinical and instrumental variables in patients suffering from herniated intervertebral discs, with the complication of spinal canal stenosis was established.
Features of the proteo-peptidome composition and the influence of the scorpion venom toxins on the srtucture of the heart of mammals (Review)
Authors: Samborska Inga , Maievskyi Oleksandr , Yanchyshyn Andrii , Dzevelska Iryna
Published: November 2024

This crucial research aimed to determine the profound influence of scorpion venom toxins on the intricate structure of the heart of mammals, a topic of utmost importance in toxicology and cardiovascular health.
Materials and methods. A meticulous and comprehensive literature analysis was conducted using PubMed, Google Scholar, Web of Science, and Scopus databases. We meticulously selected the newest publications up to 5 years old or the most thorough publications that vividly described our topic's essence, ensuring our findings' credibility and reliability.
Conclusions. Scorpion venom is a complex of biologically active substances that have a wide range of effects on the vital systems of the victim's body. Violations of the normal functioning of the cardiovascular system occur both as a result of disorders of the conduction system of the heart and as a result of pronounced morphological changes in the tissues of the organ. In particular, the development of inflammatory processes of the myocardium, the formation of blood clots in the heart vessels, degeneration of myofibrils, fragmentation of fibres, haemorrhages, etc., are characteristic under these conditions. In addition, these changes are accompanied by the production of pro-inflammatory cytokines, apoptosis factors, and the development of OS.
Investigating the non-equilibrium in territorial space utilization benefits of urban agglomerations under new urbanization: A case study of the Pearl River Delta of China
Authors: Bai Yifan , Xun Jiayue , Xu Gaofeng
Published: November 2024

The National Development and Reform Commission’s 14th 5-year Plan for New Urbanization aims to enhance the integrated development of urban agglomerations and promote coordinated growth among large, medium, and small cities to improve the comprehensive development capacity of urban agglomerations. This study examines the systemic coupling and coordination of land use benefits and the concept of balanced territorial space utilization. A comprehensive evaluation index system is constructed, employing the coupling coordination degree model and the land development imbalance index model to assess both the comprehensive benefits of land use and the balance of land development in the nine cities of the Pearl River Delta urban agglomeration in 2019. The findings are as follows: (i) Shenzhen has the largest territorial space development scale, with minor differences indicating balanced development; (ii) the territorial space development scale and urban economic benefits in the Pearl River Delta urban agglomeration are generally in a coordinated development stage. While Guangzhou and Shenzhen exhibit lagging input, the other cities demonstrate lagging output; and (iii) there is an extreme imbalance in territorial space development. Based on these findings, the study recommends the following: (i) maintain coordinated development between territorial space development scale and urban economic benefits by adjusting inputs and outputs across different cities to control land development intensity and enhance the economic output of land; and (ii) for cities facing overdevelopment, prioritize improving urban land supply capacity, control the expansion of construction land, and explore the redevelopment of existing land; for cities facing underdevelopment, provide preferential access to construction land quotas to support efficient land development.
Stirring the Ashes
Authors: Blouin Philippe
Published: November 2024

This article draws on participant observation in a legal battle at the Quebec Superior Court in 2022, where the Kanien’kehá:ka Kahnistensera (Mohawk Mothers) sought an injunction to halt excavation work around a hospital where Indigenous victims of medical experiments were allegedly buried. In response to a motion from the government of Quebec, the Mohawk Mothers refused to use a lawyer who would obey colonial law, arguing that it was their traditional duty as caretakers of the territory to speak for themselves and for their community without legal representation. This article examines their fight for self-determination through their specific understanding of the relationship between individual autonomy and social responsibility, notably by way of the Kanien’kehá:ka’s use of a single word to denote assemblies, fires, and families: Kahwá:tsire’. To reach a consensus, when it seems that everyone has come to an agreement, the Kanien’kehá:ka council must “stir the ashes” and ask everyone who has not spoken yet to voice their opinion and bring their unique perspective in the balance. As a result of this method, the author suggests that the Kanien’kehá:ka simultaneously take on the roles of legislators, executors, and judges all at once.
Career as a Professional Accountant after becoming an alumnus of SMKN 25 Jakarta
Authors: Halim Sofyan , Roza Fachrul
Published: November 2024

Pengabdian kepada masyarakat merupakan salah satu kewajiban dosen untuk dilaksanakan sebagai bagian dari Tri Dharma Perguruan Tinggi, Program tersebut setiap tahun telah rutin dilaksanakan, pada tahun ini pelaksanaan kegiatan  dilakukan bersama dengan tim lain di SMKN 25, Jakarta.  Adapun thema besar dari program ini adalah  “Praktik Akuntan & Persiapan Dunia Kerja” dan thema Tim kami adalah Berkarir sebagai Akuntan Profesional setelah menjadi alumni SMKN 25 Jakarta.
Pelaksanaan kegiatan telah dilakukan  pada hari Kamis, tanggal 30 Mei 2024, beserta team lain. Acara dibuka secara bersama oleh Kepala Sekolah dan LPPM UMB, Para peserta sangat berantusias saat pelaksanaan acara karena mendapatkan motivasi dan diberikan pengarahan untuk berkarir sebagai Akuntan Profesional dengan bisa berkesempatan bisa berkarir di berbagai  Lembaga Pemerintah, BUMN/BUMD, Perusahaan Swasta, Kantor Akuntan Publik bahkan di Kantor Jasa Akuntan.
Berkat antusiasme para peserta didik kelas 11 merupakan genersi muda milenial yang hadir pada acara tersebut telah termotivasi dan bertambah wawasan  mereka tentang peran Akuntan di masa depan yang akan mereka arungi menata kehidupan, sehingga para anak didik tersebut bisa dan mampu menjadi Akuntan yang handal dan professional yang  bertugas pada berbagai bidang di lembaga dan institusi serta perusahaan yang berintegritas, amanah dan bertanggungjawab, serta bekerja secara professional.
Bacteremia due to strict anaerobes
Authors: Piña Delgado Carmen , Bolaños Rivero Margarita , Carmona Tello María Nieves , Ramírez Estupiñán Catalina Jesús , Hernández Cabrera Pilar Michele , de Miguel Martínez Isabel
Published: November 2024

Introduction. Anaerobic bacteremia represents 0.5-12% of all bacteremias and its mortality is high, ranging from 25-44%. The aim was to know our data to compare them with existing data and demonstrate the importance of actively searching for these microorganisms in blood culture samples. Material and methods. A retrospective descriptive study in which the medical records of patients with significant episodes of anaerobic bacteremia were reviewed over a period of 8 years (2014-2022). Results. A total of 59,898 blood cultures were processed, of which 10,451 were positive (17%). An anaerobic microorganism was identified in 209 patients. Anaerobic bacteremia accounted for 2.11% of the total number of positive blood cultures. The mean age was 63.55 years (17-96), 66% of whom were men. The origin was community in 63.64%, of nosocomial origin in 15.31% and associated with health care in 17.70%. The focus of infection was the abdominal (39.23%), followed by the respiratory (13.88%) and skin and soft tissues (13.39%). The most frequent comorbidities were: arterial hypertension (49.76%), dyslipidemia (29.67%), neoplasia (26.32%) and diabetes (26.32%). The main species isolated were the group Bacteroides spp. (44.50%) (n=93) highlighting Bacteroides group fragilis (n=65), followed by Clostridium spp. (20%) (n=42) highlighting Clostridium perfringens (n=30). The clinical evolution was good in 67.46%. The mean length of stay was 27.8 days and was associated with 20% mortality. Conclusions. Bacteremias due to anaerobes represented 2.11% of the total number of true bacteremias, so we consider the active search for these microorganisms to be appropriate.
A pedagógusképzés magyarországi oktatáspolitikai tendenciái
Authors: Soósné Faragó Magdolna
Published: November 2024

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A szakmódszertanok és szakmódszertanosok védelmében
Authors: Katona András
Published: November 2024

Vitacikknek szánja írását a szerző, aki - amellett, hogy három évtizedes tapasztalattal rendelkező metodikus — a Tanárképzők Szövetsége Szakmódszertani Szakosztályát is vezeti. A szakmódszertanosok, szaktárgyi tantárgypedagógusok helyzetét regisztráló diagnózisát követően másfél tucatnyi pontba sűrítve terápiát is ajánl, példaanyagát -történelemdidaktikát művelő szakemberről lévén szó - elsősorban a társadalomtudományok köréből merítve. Az álmok és a megvalósíthatóság határán egyensúlyozva kicsendül szavaiból a tudományterülete és művelői iránt érzett féltő aggodalom, valamint a tanár szakos hallgatók iránti tanári felelősség. Szívesen várja kollégái, olvasói reagálását, a kissé elfogultnak tűnő címnek megfelelően, de még inkább az eredményesebb tanárképzés érdekében.
A hazai főiskolai szintű tanár-, tanító- és óvóképzés pedagógiai programjai
Authors: Hunyady Györgyné
Published: November 2024

Az elemzés azon a tájékozódáson alapul, amelyet az MTA Pedagógiai Bizottsága szervezett 2003 tavaszán a pedagógusképzés pedagógiai programjairól, a képzés tartalmáról, a felhasznált szakirodalomról, az összevont szigorlatról és a záróvizsgákról. A bizottság kérésére nyolc egyetemi, öt főiskolai tanárképzési, illetve tizennyolc tanító- és óvóképzési program érkezett. Az értelemszerűen nagyon különböző jellegű programokban rejlő adattömeg feldolgozásának bonyolult munkáját Serfőző Mónika és Sárosdi Anna (ELTE Pszichológiai Doktori Iskola) végezte el. A bizottság az év folyamán - részben az érintettek részvételével - három ülésén foglalkozott a programokkal. Az egyetemi tanárképzésben tanított pedagógiáról Zrinszky László tanulmánya a Pedagógusképzés 2003. 3-4. számában megjelent, az alábbiakban a főiskolai programokról készült elemzést mutatjuk be.
Eszmecsere
Authors: Kotschy Beáta
Published: November 2024

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Irodalomtanítás és pedagógusképzés
Authors: Gordon Győri János
Published: November 2024

Az irodalomtanítás karakterváltása című kutatási program itt bemutatott részkutatásában kilenc európai és Európán kívüli oktatási rendszer jelenlegi irodalomtanításának elméleti és gyakorlati kérdéseit vizsgáltuk meg. Négy modellt sikerült elkülönítenünk, melyek közül jelen tanulmányunkban az orosz, a francia és az amerikai irodalomtanítási modellt mutatjuk be. Feltárjuk a mögöttük rejlő tudáskoncepciók és pedagógiai célok mélyreható különbözőségeit is, majd rávilágítunk, hogy ezek miképpen kényszerítenek ki egymástól lényegesen különböző pedagógusképzési formákat, amelyek némelyike elkerülhetetlenné teszi az egyetem és a tanárképzés klasszikus modelljeinek újragondolását Magyarországon is.
A szakmódszertanok és szakmódszertanosok védelmében 2.
Authors: Katona András
Published: November 2024

Egy közelmúltban, a szakmódszertanos egyetemi és főiskolai oktatók körében végzett kérdőíves felmérés első eredményeit adja közre a történelemmetodikus szerző. A széles körben történt tájékozódás országosan is reprezentatívnak mondható. A felmérés célja az volt, hogy minél egzaktabb képet nyerhessen a szakmódszertani képzésről és a szakmódszertanosok helyzetéről. Annak érdekében kívánt tájékozódni, hogy egyrészt a szakmódszertanosok önmaguk elé tükröt tarthassanak, másrészt afelmérést kezdeményező és végző Tanárképzők Szövetsége Szakmódszertani Szakosztálya különböző fórumokon és főhatóságoknál képviselhesse e hátrányos helyzetben lévő oktatói réteg érdekeit, javaslatokat fogalmazhasson meg körülményeik javítására, segítse erőfeszítéseiket tantárgyuk presztízsének a növelésére. A felmérést munkatársaival együtt összeállító, végző és összegző szerző ezúttal is szívesen várja olvasói, kollégái véleményét a témával kapcsolatban, ami lényegében felöleli a szakmódszertani képzés szinte minden gondját, baját.
Tanárképzés a Miskolci Egyetemen
Authors: Trencsényi László
Published: November 2024

A szerző a Miskolci Egyetem fiatal Bölcsészkarán kialakult tanárképzés évtizedes útját mutatja be. A folyamat lényegeként a nagyratörő, dinamikus pedagógusképzési reformtörekvéseknek a valóság kényszerítő körülményeihez való hozzászürkülését, olykor válságérzetét jeleníti meg. Van-e esélye hatékonyságnak és alternativitásnak, az iskola humanizálását valóban segítő pedagógusképzésnek általában és konkrétan egy gazdasági válságövezetben létező, likviditási gondokkal küzdőfelsőoktatási intézményben. A szerző a résztvevő megfigyelés eszközét választja a „miskolci modell’’ bemutatására - emléket állítva a lezáruló első évtizednek.
Topical Problems of Qualification of Certain Types of Crimes
Authors:   Russian State University of Justice, Moscow, Russia, Sklyarov Sergey V.
Published: November 2024

The scientific review provides answers to the questions of judges received by the Russian State University of Justice concerning the qualification of certain crimes: group crimes with a person who is not subject to criminal liability by virtue of age or insanity; the combination of crimes provided for by paragraph “b” Part 4 of Article 132 and “b” Part 3 of Article 242 of the Criminal Code of the Russian Federation; embezzlement by means of a loan with the use of the victim’s cell phone; determination of the size of alcohol-containing products; attempted sale of narcotic drugs; a combination of crimes under Аrticles 264.1 and 264.3 of the Criminal Code of the Russian Federation; cumulative offenses under Аrticles 322.1 and 322.2 (322.3) of the Criminal Code of the Russian Federation.
Can the left hand benefit from being right? The influence of body side on perceived grasping ability
Authors: Taylor Rachael L. , McLatchie Neil , Linkenauger Sally A.
Published: November 2024

Right-handed individuals (RHIs) demonstrate perceptual biases towards their right hand, estimating it to be larger and longer than their left. In addition, RHIs estimate that they can grasp larger objects with their right hand than their left. This study investigated whether visual information specifying handedness enhances biases in RHIs’ perceptions of their action capabilities. Twenty-two participants were placed in an immersive virtual environment in which self-animated, virtual hands were either presented congruently to their physical hand or mirrored. Following a calibration task, participants estimated their maximum grasp size by adjusting the size of a virtual block until it reached the largest size they thought they could grasp. The results showed that, consistent with research outside of virtual reality, RHIs gave larger estimates of maximum grasp when using their right physical hand than their left. However, this difference remained regardless of how the hand was virtually presented. This finding suggests that proprioceptive feedback may be more important than visual feedback when estimating maximum grasp. In addition, visual feedback on handedness does not appear to enhance biases in perceptions of maximum grasp with the right hand. Considerations for further research into the embodiment of mirrored virtual limbs are discussed.
Associations of IGF-1 and IGFBP-3 with aging and the development of age-associated diseases
Authors: Ilyushchenko A. K. , Matchekhina L. V. , Melnitskaia A. A. , Strazhesko I. D.
Published: November 2024

Aging is a complex biological process impacting various systems of the body, with changes occurring at molecular, cellular, and physiological levels. This review focuses on the role of insulin-like growth factors (IGFs) and insulinlike growth factor-binding proteins (IGFBPs) in aging process. IGF-1 is crucial for the regulation of cell growth, metabolism, and apoptosis, while IGFBP-3 modulates the bioavailability of IGFs by binding to them and influencing their receptor interactions. This article outlines the mechanisms of action of IGF-1 and IGFBP-3 and discusses clinical research findings on their significance in aging, longevity, and the development of age-associated diseases. A literature search was conducted using Scopus and PubMed databases, focusing on fundamental and clinical studies. The search utilized keywords such as «insulin-like growth factors», «insulin-like growth factor-binding proteins», «aging» and «ageassociated diseases».
The gut microbiome as a central player in aging: mechanisms and health outcomes
Authors: Melnitskaia A. A. , Matchekhina L. V. , Ilyushchenko A. K. , Strazhesko I. D.
Published: November 2024

The article explores the mechanisms by which the gut microbiome influences human aging and associated diseases. The authors examine age-related changes in the composition of the microbiota and their effects on inflammation, immune response, and intestinal barrier permeability. Special attention is given to the pathogenic interactions between the gut microbiota and the development of cardiovascular, metabolic, and neurodegenerative diseases. The role of microbiome imbalance, known as dysbiosis, is highlighted as one of the key mechanisms accelerating the aging process. The review provides a comprehensive analysis of recent studies that demonstrate the impact of microbial metabolites on various body systems through the «gut-brain,» «gut-cardiovascular,» and «gut-endocrine» axes.
Ion-induced surface reactions and deposition from Pt(CO)2Cl2 and Pt(CO)2Br2
Authors: Abdel-Rahman Mohammed K , Eckhert Patrick M , Chaudhary Atul , Johnson Johnathon M , Yu Jo-Chi , McElwee-White Lisa , Fairbrother D Howard
Published: November 2024

Ion beam-induced deposition (IBID) using Pt(CO)2Cl2 and Pt(CO)2Br2 as precursors has been studied with ultrahigh-vacuum (UHV) surface science techniques to provide insights into the elementary reaction steps involved in deposition, complemented by analysis of deposits formed under steady-state conditions. X-ray photoelectron spectroscopy (XPS) and mass spectrometry data from monolayer thick films of Pt(CO)2Cl2 and Pt(CO)2Br2 exposed to 3 keV Ar+, He+, and H2+ ions indicate that deposition is initiated by the desorption of both CO ligands, a process ascribed to momentum transfer from the incident ion to adsorbed precursor molecules. This precursor decomposition step is accompanied by a decrease in the oxidation state of the Pt(II) atoms and, in IBID, represents the elementary reaction step that converts the molecular precursor into an involatile PtX2 species. Upon further ion irradiation these PtCl2 or PtBr2 species experience ion-induced sputtering. The difference between halogen and Pt sputter rates leads to a critical ion dose at which only Pt remains in the film. A comparison of the different ion/precursor combinations studied revealed that this sequence of elementary reaction steps is invariant, although the rates of CO desorption and subsequent physical sputtering were greatest for the heaviest (Ar+) ions. The ability of IBID to produce pure Pt films was confirmed by AES and XPS analysis of thin film deposits created by Ar+/Pt(CO)2Cl2, demonstrating the ability of data acquired from fundamental UHV surface science studies to provide insights that can be used to better understand the interactions between ions and precursors during IBID from inorganic precursors.
Advances in radical peroxidation with hydroperoxides
Authors: Bityukov Oleg V , Serdyuchenko Pavel Yu , Kirillov Andrey S , Nikishin Gennady I , Vil’ Vera A , Terent’ev Alexander O
Published: November 2024

Organic peroxides have become sought-after functionalities, particularly following the multi-tone consumption in polymer production and success in medicinal chemistry. The selective introduction of a peroxide fragment at different positions on the target molecule is a priority in the modern reaction design. The pioneering Kharasch–Sosnovsky peroxidation became the basic universal platform for the development of peroxidation methods, with its great potential for rapid generation of complexity due to the ability to couple the resulting free radicals with a wide range of partners. This review discusses the recent advances in the radical Kharasch-type functionalization of organic molecules with OOR fragment including free-component radical couplings. The discussion has been structured by the type of the substrate of radical peroxidation: C(sp3)–H substrates; aromatic systems; compounds with unsaturated C–C or C–Het bonds.
LITERATURE REVIEW TERAPI MUSIK UNTUK MENURUNKAN STRES PADA REMAJA
Authors: Ulfatun Najiha  , Maryana
Published: November 2024

Stres adalah masalah yang diakibatkan oleh ketidakseimbangan antara kemampuan dan tuntutan sehingga menyebabkan terjadinya gangguan fisik maupun psikologis. Stres dapat terjadi dikarenakan oleh frustrasi, konflik, tekanan, dan krisis. Salah satu terapi yang digunakan untuk mengatasi stres adalah dengan terapi musik. Terapi musik dapat membuat individu mengungkapkan perasaan mereka dan membuat perubahan positif pada suasana hati. Tujuan dari literatur ini adalah untuk mengetahui apakah terapi musik dapat menurunkan stres dari beberapa jurnal penelitian yang ditujukan untuk remaja. Metode yang digunakan yaitu metode literatur review. Literature review merupakan penelusuran dan penelitian  kepustakaan  dengan  membaca  berbagai  buku,  jurnal,  dan  terbitan  lain,  yang  berkaitan dengan topik penelitian, dan tujuannya sebagai contect review dengan mengumpulkan 7 artikel atau jurnal,  artikel  ini  dijadikan  sampel. Hasil dari  7  artikel  menggambarkan  bahwa  terapi musik dapat menurunkan  stres pada remaja. Kesimpulan  yang diperoleh berdasarkan hasil yang didapatkan  menunjukkan bahwa terapi musik dapat menurunkan  stres pada remaja, setelah dilakukan terapi musik  mereka merasa lebih mudah untuk mengatasi stres, ketegangan, rasa sakit, dan berbagai gangguan atau gejolak emosi negatif yang dialaminya.
Genetic Landscape and Clinical Manifestations of Multiple Endocrine Neoplasia Type 1 in a Korean Cohort: A Multicenter Retrospective Analysis
Authors: Kim Boram , Lee Seung Hun , Ahn Chang Ho , Jang Han Na , Cho Sung Im , Lee Jee-Soo , Lee Yu-Mi , Kim Su-Jin , Sung Tae-Yon , Lee Kyu Eun , Lee Woochang , Koh Jung-Min , Seong Moon-Woo , Kim Jung Hee
Published: November 2024

Background: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by tumors in multiple endocrine organs, caused by variants in the MEN1 gene. This study analyzed the clinical and genetic features of MEN1 in a Korean cohort, identifying prevalent manifestations and genetic variants, including novel variants.Methods: This multicenter retrospective study reviewed the medical records of 117 MEN1 patients treated at three tertiary centers in Korea between January 2012 and September 2022. Patient demographics, tumor manifestations, outcomes, and MEN1 genetic testing results were collected. Variants were classified using American College of Medical Genetics and Genomics (ACMG) and French Oncogenetics Network of Neuroendocrine Tumors propositions (TENGEN) guidelines.Results: A total of 117 patients were enrolled, including 55 familial cases, with a mean age at diagnosis of 37.4±15.3 years. Primary hyperparathyroidism was identified as the most common presentation (84.6%). The prevalence of gastroenteropancreatic neuroendocrine tumor and pituitary neuroendocrine tumor (PitNET) was 77.8% (n=91) and 56.4% (n=66), respectively. Genetic testing revealed 61 distinct MEN1 variants in 101 patients, with 18 being novel. Four variants were reclassified according to the TENGEN guidelines. Patients with truncating variants (n=72) exhibited a higher prevalence of PitNETs compared to those with non-truncating variants (n=25) (59.7% vs. 36.0%, P=0.040).Conclusion: The association between truncating variants and an increased prevalence of PitNETs in MEN1 underscores the importance of genetic characterization in guiding the clinical management of this disease. Our study sheds light on the clinical and genetic characteristics of MEN1 among the Korean population.
Rotating Spacetime: Theory or Reality? A Concise Journey of General Relativity
Authors: Tasneem Sabiha
Published: November 2024

The paper reviews the theoretical formulae of different astrophysical conditions to describe spacetime and connects theory with observational evidence. The spacetime is governed by gravity, which is well-explained by the theory of General Relativity. The paper starts from the simplest version of spacetime, that is, flat spacetime which has no gravitational influence. This spacetime is described by the Minkowski metric. Then the paper goes to the properties of spacetime in the presence of gravity, which creates curved spacetime. The Schwarzschild metric defines this spacetime. Although these phenomena are well-established by experimental proof, the most intricate characteristic of spacetime has not been discovered until very recently. That is the spacetime around a rotating massive body. The paper will present the mathematical expressions for describing such spacetime, the Kerr metric, and finally will end with the observational evidence of the effect of a spinning heavy body around it. Some particular exotic effects such as “frame-dragging" and “ergosphere" will be presented in brief.
Peran Roh Kudus dalam Transformasi Hidup Orang Percaya untuk Menanggalkan Kebiasaan Lama Otomatis
Authors: Tulus Jekson , Duha Sang Putra Immanuel
Published: November 2024

Berada di lingkungan rohani tidak menjamin seseorang mengalami transformasi kehidupan. Tidak ada jaminan kalau orang percaya bebas sepenuhnya dari dosa dan perbuatan daging. Bagaimana melatih tubuh fisik untuk menonaktifkan kebiasaan-kebiasaan dosa yang sudah menjadi otomatis, menjadi rumusan masalah dalam tulisan ini. Peneliti menemukan kebaruan metode untuk dapat dipraktikkan oleh orang percaya dalam usahanya untuk bertobat sungguh-sungguh. Dengan mengintegrasikan iman Kristen dan psikologi pendekatan Neuropsikologi, penelitian ini akan menolong orang percaya untuk dapat melihat secara lebih objektif bagaimana tubuh membentuk kebiasaan-kebiasaan menjadi respons permanen (otomatis). Peneliti menyimpulkan, dalam proses membangun kebiasaan benar otomatis, baik Roh Kudus maupun pribadi yang bersangkutan harus memainkan perannya masing-masing.
Promoting economic recovery: the silver lining of digital transformation and corporate innovation
Authors: Du Zhuo-Ya , Wang Qian
Published: November 2024

With the unstable international environment, the global economy has experienced a slowcession. Previous research on digital innovation in firms has often neglected the impact of macroeconomic cycles. This paper examines the moderating effect of the economic slowcession in the digital transformation and corporate innovation nexus, by using the China’s A-share listed companies’data during 2001 and 2021. The empirical results find that the positive impact of digitization on innovation is countercyclical. During recession, the positive impact of digital transformation on innovation is even greater compared to economic prosperity. Grouped regression results indicate that State-owned listed companies, Non-high tech companies, Large-scale companies, and Eastern companies are more affected by the positive moderating effect of the recession. This indicates that getting out of recession requires more aggressive support of these companies, which promotes innovation and economic recovery. This study provides a useful reference for countries in recession and provides an important complement to traditional economic cycle theory and innovation cycle theory.
Unveiling the impact of improvement methodologies on employee engagement: Insights from central European companies
Authors: Urban Wieslaw
Published: November 2024

Improvement methodologies (IMs) consist of many components; however, employee engagement (EE) is particularly important in bottom-up initiated process improvement. This study aims to investigate EE with reference to IMs used by companies. EE measurement constructs focused on process improvement has been developed and verified as reliable. This study examines a sample of 380 medium- and large-sized companies. The ANOVA procedure proves that: (1) IMs support EE in companies, and (2) the absence of IMs leads to lower EE. However, support for EE is specific and does not primarily concern issues directly related to process improvement. This study also discovers the multi-use of IMs by companies. IMs such as Lean, strongly focused on EE by their assumptions, only moderately support EE in companies. The study found no exceptionally effective IM which allows for the easy gain of EE in the investigated companies’ current state of implementation. The results imply that companies are approximately halfway towards the effective use of IMs. They should rethink the use of IMs, transform their leadership style, and better motivate employees to engage in bottom-up process improvement, which is indispensable.
Leaning Sideways: VHS 1256−1257 b is a Super-Jupiter with a Uranus-like Obliquity
Authors: Poon Michael , Bryan Marta L. , Rein Hanno , Morley Caroline V. , Mace Gregory , Zhou Yifan , Bowler Brendan P.
Published: November 2024

We constrain the angular momentum architecture of VHS J125601.92-125723.9, a 140 ± 20 Myr old hierarchical triple system composed of a low-mass binary and a widely separated planetary-mass companion, VHS 1256 b. VHS 1256 b has been a prime target for multiple characterization efforts, revealing the highest measured substellar photometric variability to date and the presence of silicate clouds and disequilibrium chemistry. Here we add a key piece to the characterization of this super-Jupiter on a Tatooine-like orbit: we measure its spin-axis tilt relative to its orbit, i.e., the obliquity of VHS 1256 b. We accomplish this by combining three measurements. We find a projected rotation rate

v
sin

i

p

=
8.7
±
0.1

km

s

−
1

for VHS 1256 b using near-infrared high-resolution spectra from Gemini/IGRINS. Combining this with a published photometric rotation period indicates that the companion is viewed edge on, with a line-of-sight spin axis inclination of i
p = 90° ± 18°. We refit available astrometry measurements to confirm an orbital inclination of

i
o

=

23

−
13

+
10

degrees. Taken together, VHS 1256 b has a large planetary obliquity of ψ = 90° ± 25°. In total, we have three measured angular momentum vectors for the system: the binary orbit normal, companion orbit normal, and companion spin axis. All three are misaligned with respect to each other. Although VHS 1256 b is tilted like Uranus, their origins are distinct. We rule out planet-like scenarios including collisions and spin–orbit resonances, and suggest that top-down formation via core/filament fragmentation is promising.
A Near-infrared Survey of Candidate Haumea Family Members
Authors: Proudfoot Benjamin C. N. , Fernández-Valenzuela Estela , Stansberry John A. , Kiss Csaba , Ragozzine Darin , Fraser Wesley C. , Pike Rosemary E. , Pinilla-Alonso Noemi
Published: November 2024

The Haumea family is the only known dynamical family in the trans-Neptunian region. To date, 10 family members have been unambiguously identified using near-infrared (NIR) spectral or photometric data in combination with their strong dynamical proximity and the rest of the family. In this work, we build off previous empirically constructed models of the family to identify 39 candidate family members and follow up on eight of them using the Hubble Space Telescope (HST) to measure their visible and NIR colors. Six of the candidates have strong water-ice absorption features—consistent with family membership. Based on these initial findings, our sample of 39 candidate family members should contain about 20 more water-rich objects. Combining the HST visible and NIR photometry with past results, we find no evidence for significant color heterogeneity within the family. Of the six new family members, two have Δv ∼ 300 m s−1, well outside of the traditionally defined velocity dispersion limit of ∼150 m s−1. As evidence suggests they are not affected by any of Neptune’s resonances, we propose that these family members are the result of dynamical sculpting by Neptune during its outward migration. Further searches for far-flung family members will be able to further explore this hypothesis.
No Evidence for a Metallicity-dependent Enhancement of Distant Giant Companions to Close-in Small Planets in the California Legacy Survey
Authors: Van Zandt Judah , Petigura Erik A.
Published: November 2024

Understanding the relationship between close-in small (CS) planets and distant giants (DGs) is central to understanding the formation of planetary systems like our own. Most studies of this connection have found evidence for a positive correlation, though significant statistical and systematic uncertainties remain due to differences in sample size, target selection bias, and even the definitions of CS and DG planets. Recently, M. L. Bryan & E. J. Lee conducted a study of 184 stars hosting super-Earths (

M
sin
i
=
1
−
20

M
⊕

or R = 1 − 4 R
⊕) to determine the effect of stellar metallicity on the prevalence of DG companions (

M
sin
i
=
0.5
−
20

M
J

, a = 1−10 au). They found that such giants are twice as common in the presence of inner planets, but only in metal-rich systems: P(DG∣CS, [Fe/H] > 0) =

28.0

−
4.6

+
4.9

%

versus P(DG∣[Fe/H] > 0) =

14.3

−
1.8

+
2.0

%

. Further, they found that this correlation disappears for metal-poor stars: P(DG∣CS, [Fe/H] ≤ 0) =

4.5

−
1.9

+
2.6

%

versus P(DG∣[Fe/H] ≤ 0) =

5.0

−
1.3

+
1.6

%

. We conducted an analogous study to test whether this effect was present in the California Legacy Survey sample. Using the same planet definitions, we did not find evidence for an enhancement in metal-rich systems: P(DG∣CS, [Fe/H] > 0) =

14

−
8

+
11

%

versus P(DG∣[Fe/H] > 0) =

17.9

−
2.4

+
2.5

%

. We also found a 2σ tension between our conditional rate and a 2x enhancement. We brought our results into closer agreement with M. L. Bryan & E. J. Lee by repeating our analysis with different planet definitions. For example, considering only CS planets with

1
≤
M
sin
i
≤
10

M

⊕

and DG planets with

0.5
≤
M
sin
i
≤
20

M

J

gives P(DG∣CS, [Fe/H] > 0) =

48

−
17

+
17

%

and P(DG∣[Fe/H] > 0) =

21.8

−
2.7

+
2.9

%

, consistent with a 2x enhancement. However, we find that this 2x enhancement is also present when we apply the same planet definitions to the overall sample, challenging the idea that metallicity is responsible. Our sample, though only ∼1/6 the size of M. L. Bryan & E. J. Lee, was assembled and analyzed self-consistently. The discrepancy between our findings and theirs may arise from a variety of sources, underscoring the need for large exoplanet surveys to overcome both small number statistics and sample inhomogeneities.
The SAGA Survey. V. Modeling Satellite Systems around Milky Way–Mass Galaxies with Updated UniverseMachine
Authors: Wang Yunchong , Nadler Ethan O. , Mao Yao-Yuan , Wechsler Risa H. , Abel Tom , Behroozi Peter , Geha Marla , Asali Yasmeen , de los Reyes Mithi A. C. , Kado-Fong Erin , Kallivayalil Nitya , Tollerud Erik J. , Weiner Benjamin , Wu John F.
Published: November 2024

Environment plays a critical role in shaping the assembly of low-mass galaxies. Here, we use the UniverseMachine (UM) galaxy–halo connection framework and Data Release 3 of the Satellites Around Galactic Analogs (SAGA) Survey to place dwarf galaxy star formation and quenching into a cosmological context. UM is a data-driven forward model that flexibly parameterizes galaxy star formation rates (SFRs) using only halo mass and assembly history. We add a new quenching model to UM, tailored for galaxies with m
⋆ ≲ 109
M
⊙, and constrain the model down to m
⋆ ≳ 107
M
⊙ using new SAGA observations of 101 satellite systems around Milky Way (MW)–mass hosts and a sample of isolated field galaxies in a similar mass range from the Sloan Digital Sky Survey. The new best-fit model, “UM-SAGA,” reproduces the satellite stellar mass functions, average SFRs, and quenched fractions in SAGA satellites while keeping isolated dwarfs mostly star-forming. The enhanced quenching in satellites relative to isolated field galaxies leads the model to maximally rely on halo assembly to explain the observed environmental quenching. Extrapolating the model down to m
⋆ ∼ 106.5
M
⊙ yields a quenched fraction of ≳30% for isolated field galaxies and ≳80% for satellites of MW-mass hosts at this stellar mass. Spectroscopic surveys can soon test this specific prediction to reveal the relative importance of internal feedback, cessation of mass and gas accretion, satellite-specific gas processes, and reionization for the evolution of faint low-mass galaxies.
A Hierarchical Bayesian Approach to Point-source Analysis in High-energy Neutrino Telescopes
Authors: Capel Francesca , Kuhlmann Julian , Haack Christian , Ha Minh Martin , Niederhausen Hans , Schumacher Lisa
Published: November 2024

We propose a novel approach to the detection of point-like sources of high-energy neutrinos. Motivated by evidence for emerging sources in existing data, we focus on the characterization and interpretation of these sources rather than the rejection of the background-only hypothesis. The hierarchical Bayesian model is implemented in the Stan platform, enabling computation of the posterior distribution with a Hamiltonian Monte Carlo algorithm. We simulate a population of weak neutrino sources detected by the IceCube experiment and use the resulting data set to demonstrate and validate our framework. We show that even for the challenging case of sources at the threshold of detection and using limited prior information, it is possible to correctly infer the source properties. Additionally, we demonstrate how modeling flexible connections between similar sources can be used to recover the contribution of sources that would not be detectable individually. While a direct comparison of our method to existing approaches is challenged by the fundamental differences in frequentist and Bayesian frameworks, we draw parallels where possible. In particular, we highlight how including more complexity into the source modeling can increase the sensitivity to sources and their populations.
The Next Step in Galaxy Cluster Strong Lensing: Modeling the Surface Brightness of Multiply Imaged Sources*
Authors: Acebron Ana , Grillo Claudio , Suyu Sherry H. , Angora Giuseppe , Bergamini Pietro , Caminha Gabriel B. , Ertl Sebastian , Mercurio Amata , Nonino Mario , Rosati Piero , Wang Han , Bolamperti Andrea , Meneghetti Massimo , Schuldt Stefan , Vanzella Eros
Published: November 2024

Overcoming both modeling and computational challenges, we present, for the first time, the extended surface-brightness distribution model of a strongly lensed source in a complex galaxy-cluster-scale system. We exploit the high-resolution Hubble Space Telescope (HST) imaging and extensive Multi Unit Spectroscopic Explorer spectroscopy to build an extended strong-lensing model, in a full multiplane formalism, of SDSS J1029+2623, a lens cluster at z = 0.588 with three multiple images of a background quasar (z = 2.1992). Going beyond typical cluster strong-lensing modeling techniques, we include as observables both the positions of 26 pointlike multiple images from seven background sources, spanning a wide redshift range between 1.02 and 5.06, and the extended surface-brightness distribution of the strongly lensed quasar host galaxy, over ∼78,000 HST pixels. In addition, we model the light distribution of seven objects, angularly close to the strongly lensed quasar host, over ∼9300 HST pixels. Our extended lens model reproduces well both the observed intensity and morphology of the quasar host galaxy in the HST F160W band (with a 0.″03 pixel scale). The reconstructed source shows a single, compact, and smooth surface-brightness distribution, for which we estimate an intrinsic magnitude of 23.3 ± 0.1 in the F160W band and a half-light radius of (2.39 ± 0.03) kpc. The increased number of observables enables the accurate determination of the total mass of line-of-sight halos lying angularly close to the extended arc. This work paves the way for a new generation of galaxy cluster strong-lens models, where additional, complementary lensing observables are directly incorporated as model constraints.