bluuebunny/crossref_metadata_2025 huggingface dataset:
STRATEGI SATUAN POLISI PAMONG PRAJA DALAM PENYELENGGARAAN KETENTRAMAN, KETERTIBAN UMUM DAN PERLINDUNGAN MASYARAKAT
Authors: Sopandi Andi , Mulyana R. Achmad
Published: December 2024

Strategi Satuan Polisi Pamong Praja Kota Bekasi dalam melaksanakan perdamaian, ketertiban umum, dan perlindungan masyarakat di Kota Bekasi memerlukan kajian yang komprehensif. Tujuan tulisan ini adalah untuk menganalisis strategi yang dilakukan oleh Satuan Polisi Pamong Praja Kota Bekasi dalam penyelenggaraan ketentraman, ketertiban umum, dan perlindungan masyarakat. Penelitian menggunakan pendekatan kualitatif dengan teknik pengumpulan data melalui wawancara dan diskusi terfokus. Teknik analisis data menggunakan teknik triangulasi. Hasil yang diperoleh menunjukan bahwa terdapat: (a) inventarisasi kondisi ketertiban umum dan ketenangan di Kota Bekasi; (b) Upaya untuk memantau dan mengevaluasi titik-titik kerentanan yang dapat mengganggu ketertiban umum dan ketenangan; dan (c) menjalankan strategi serta mencegah dan menindak setiap kasus yang mengganggu ketertiban dan ketenangan masyarakat.
PERAN DINAS KOPERASI, USAHA KECIL DAN MENENGAH DALAM PENGEMBANGAN PELAKU USAHA MIKRO KECIL MENENGAH
Authors: Farismah Agustin Isnaeni , Fadil Muhammad
Published: December 2024

Indonesia ialah suatu negara dalam kategori berkembang yang ditandai dengan kegiatan utama dalam pemerintahan yakni pembangunan nasional. Posisi sektor ekonomi sangat diperhitungkan dalam pembangunan nasional di Indonesia. Perekonomian yang masih bergejolak, membuat masyarakat merasa hidupnya semakin sulit. Perkembangan zaman masa kini mempengaruhi tuntutan masyarakat yang semakin meningkat akan cara hidupnya, dan cara berpikir masyarakat menjadi semakin modern, terkonsep, semakin canggih dan kompleks. Koperasi Usaha Kecil Menengah Kota Bekasi dengan pengembangan UMKM berdasarkan Renstra Strategis Tahun 2018-2023. Pemerintah Kota Bekasi memiliki wewenang lebih luas dalam merancang dan melaksanakan setiap kebijakan di tingkat daerah kecuali urusan yang ditetapkan menjadi kewenangan pusat dan provinsi. Upaya dalam mendorong pembangunan di Kota Bekasi untuk mencapai Visi Misi Kota Bekasi merupakan suatu hal yang kompleks serta tidak dapat dilaksanakan dengan menggunakan pendekatan manajemen yang parsial dan sektoral. Hasil penelitian pada Dinas Koperasi Usaha Kecil Menengah Kota dengan metode teknik pengumpulan data, observasi, wawancara, dan dokumentasi dapat disimpulkan masih belum berjalan secara optimal.
THE MARGINALIZATION OF WOMAN LEADER IN MALANG CITY
Authors: Haboddin Muhtar
Published: December 2024

The article aims to explain the marginalization of women in leadership in Malang City. It turns out that the marginalization of women has been going on for a long time. Since 1942 until now women have never succeeded in becoming political leaders. This means that the political structure in Malang City is very male. The domination of men over women is a sign that political reform through direct elections does not have a positive impact on women's position in politics. The position of women is still weak and powerless against men in the mayoral election. Therefore, it is necessary to do two things simultaneously, namely encouraging political participation and developing social awareness for women so that they continue to struggle and compete for political leadership. The struggle to seize political leadership is an important agenda in building substantive democracy in Malang City.
Diving Tour Package Design With Business Model Canvas Approach At Nukila Dive Center Ternate, North Maluku
Authors: Ramadhan Moehamad Alfari , Suryana Asep Agus Handaka , Prihadi Donny Juliandri , Kristiandhi Fanny , Pamungkas Wahyuniar
Published: December 2024

The development of marine tourism in Ternate has shown significant growth in recent years. The island offers marine ecotourism in the form of stunning underwater beauty, with beautiful coral reefs and rich marine biodiversity. Nukila Dive Center has an important role in the sustainability of tourism to support the tourism industry in Ternate. The business model approach is one of the important factors for the success of a company. The purpose of this study is to identify the Nukila Dive Center business model and identify the steps to create a conservation-based diving tour package. The business modeling method and the design of a conservation-based diving tour package are analyzed with nine elements of the business model canvas. Increasing value propositions, customer segments, and customer relationships will affect a company's income. Based on the results of the study, the elements of the business model at Nukila Dive Center were identified, namely the existing customer segments, namely domestic and foreign tourists. The value proposition offered is in the form of attractive underwater nature tourism. The current customer relationship is a direct relationship not only individually, but also with groups/diving communities and sea transportation associations. Revenue Streams received from diving trips, certification and equipment rental. Key resources in trip diving are the underwater beauty in the form of coral reefs and their ecosystems, as well as human resources. The existing key activities are trip diving and certification, Key partnerships currently carried out are travel agents, diving equipment providers, government agencies, diving communities. Cost Structures include ship fuel, equipment and facility maintenance, staff salaries. The prototype design that was made aims to be able to add value proposition to help add value at Nukila Dive Center to add new customer segments with the output of conservation-based diving tour packages in the form of e-flyers
Regenerative Marine Tourism Strategy in The Ecosystem of Momparang Archipelago, East Belitung
Authors: Dani Fauzi  , Syafutra Randi , Agustina Erlingga
Published: December 2024

This research formulates a regenerative marine tourism strategy for the Momparang Archipelago, East Belitung, using the seven regenerative tourism principles. Key results show that conservation initiatives, such as coral reef restoration and environmental education, have engaged local fishermen and tourism operators in sustainability efforts. However, challenges in waste management and governance remain, requiring stronger frameworks to ensure long-term success. The study employs a qualitative approach with Logical Framework Analysis (LFA) to systematically identify goals, objectives, activities, and expected outcomes. Leveraging the region's unique cultural and ecological assets, such as shipwreck sites and Bugis Buton heritage, has been shown to enhance the destination’s appeal. Community involvement in conservation and waste management is critical to achieving a sustainable tourism model. Key recommendations include the formation of a multi-stakeholder regenerative tourism advisory board and continuous public education on sustainable practices. Future research should explore the broader application of regenerative tourism principles in other coastal areas, focusing on collaboration between government, local communities, and the private sector. Additionally, innovative waste management strategies that involve active tourist participation should be further investigated to enhance both environmental sustainability and visitor experience. This research offers a foundation for transforming the Momparang Archipelago into a model for sustainable regenerative tourism.
Implementation of Hadith as a Foundation for Deradicalization in Contemporary Islamic Education Curriculum
Authors: Yusuf M. Fajri , Siregar Bona Bargot Riezky Nagabe , Harahap Alwi Padly
Published: December 2024

Radicalism and religious extremism have become global issues that pose significant challenges to the world of education, especially in the context of Islam. Islamic education is one of the most effective tools to counter radicalism. However, an overly rigid and dogmatic approach to education can sometimes exacerbate the problem. This study aims to build a hadith-based curriculum as a foundation for deradicalization. This study uses a qualitative method with descriptive-analytic data analysis techniques. The study’s results indicate several hadiths that, if integrated into the Islamic education curriculum, can strengthen the values of peace, and tolerance, and prevent radicalism. Implementing these hadiths in educational materials can provide a more balanced understanding of religion and foster critical attitudes and tolerance among students. Effective implementation requires the selection of relevant hadiths, contextual interpretation, development of teaching materials, and good teacher training. This study is expected to provide specific benefits for educational institutions in designing a curriculum that functions as an instrument for deradicalization based on religious teachings. Thus, this study contributes to creating a generation that is moral, tolerant, and able to face global challenges without losing its moderate religious identity.
The Turun Mani Tradition in Gayo: an Analysis of Hadith on Aqiqah in Central Aceh
Authors: Melala Al-Farabi , Halim Abdul
Published: December 2024

This study explores the integration of local traditions within Islam through an examination of the Turun Mani tradition among the Gayo community in Central Aceh. This tradition represents a unique implementation of the Aqiqah ritual, incorporating local cultural elements and reflecting harmony between Islamic teachings and local customs. The research aims to examine the practice of the Turun Mani tradition, understand the Gayo community's perception of hadiths related to Aqiqah, and analyze the quality of the referenced hadiths. Employing a qualitative method with a living hadith approach, this study involves in-depth interviews with selected informants, including religious leaders, cultural figures, and practitioners of the tradition, as well as literature reviews of hadiths and primary texts. The findings reveal that the Turun Mani tradition adapts local cultural elements—such as the Begenap ritual, bathing the newborn with coconut water and kaffir lime, and protective prayers—while preserving the essence of Aqiqah. The Gayo community’s understanding of the hadiths underlying this tradition is largely inherited and lacks critical examination of the hadiths' authenticity. The Turun Mani tradition not only reinforces local wisdom but also supports the primary objectives of Maqāṣid al-Syarī‘ah, such as protecting faith, life, lineage, and intellect. Despite challenges posed by modernization, the tradition endures as a manifestation of harmony between religion and culture. This research contributes to the study of living hadith and the relationship between Islam and local traditions in Indonesia.
MENULIS DI KALANGAN GURU BAHASA INDONESIA: Sebuah Fakta Kepenulisan Guru SMP di Surabaya
Authors: Yuanita Arie , Yuwana Setya , Yohanes Budinuryanta , Ahmadi Anas , Asteria Prima Vidya
Published: December 2024

PKM yang berjudul ”Pelatihan Penulisan Artikel Ilmiah dan Artikel Populer Untuk Guru SMP di Surabaya Barat” ini bertujuan untuk meningkatkan pemahaman/pengetahuan para guru SMP di Surabaya Barat tentang artikel ilmiah dan populer serta meningkatkan kemampuan menulis artikel ilmiah dan populer yang sesuai aturan yang benar. Target PKM ini adalah guru-guru SMP di wilayah Surabaya Barat. Metode yang digunakan adalah pemberian materi dilakukan dengan menggunakan metode ceramah dari para pemateri. Metode selanjutnya yaitu melalui tanya jawab. Kemudian, untuk prosedur pelaksanaan pelatihan ini dapat dibagi menjadi beberapa tahap yaitu tahap persiapan, tahap pelaksanaan, tahap penutup, serta tahap evaluasi. Dari hasil evaluasi didapatkan hasil bahwa artikel peserta tidak memilki kesamaan atau bukan plagiat dari artikel lain seyelah dilakukan cek plagiarisme namun dalam hal kebahasaan masih terdapat beberapa kesalahan dalam ejaan dan penulisan kata
Recycling Sampah Plastik Menjadi Produk Bernilai Jual
Authors: Hulaikah Mifta
Published: December 2024

The use of food wrap made of plastic is very popular because plastic is lightweight, easy to carry and of course the price is affordable. This results in a lot of plastic waste. One way to reduce it is with the 3R program (reuse, reduce, recycle). In addition, the problem experienced by the community is that plastic waste is not utilized as a selling value product so that it is expected to increase side income for housewives. This service aims to provide training on recycling plastic waste into products that are worth selling.
Pelatihan Alat Evaluasi Berbasis HOTS Bagi Guru MGMP Daring dan Pemasaran Kabupaten Magetan
Authors: Sudarwanto Tri , Harti  , Saino  , Sulistyowati Raya
Published: December 2024

An abstranct is a brief summary of a research article, thesis, review, conference proceeding or any-depth analysis of a particular subject or disipline, and is often used to help the reader quickly ascertain the paper purposes. When used, an abstract always appears at the beginning of a manuscript or typescript, acting as the point-of-entry for any given academic paper or patent application. Absatrcting and indexing services for various academic discipline are aimed at compiling a body of literature for that particular subject. Abstract length varies by discipline and publisher requirements. Abstracts are typically sectioned logically as an overview of what appears in the paper.
Overview Laporan Keuangan UPK Mitra Mandiri di Kec. Pragaan, Sumenep, Madura
Authors: Aprilia Firda Alfaini , Agustina Rachma
Published: December 2024

Financial statements are a form of delivery, notification or liability that contains about a company’s financial information to describe the performance of the company. SAK ETAP or financial accounting standards for entities without public accountability are accounting standards used by entities that do not have significant accountability and and publish financial statements for the same purposes. The purpose of this study is to find out the results of financial statement analysis in accordance with SAK ETAP at UPK Mitra Mandiri in Pragaan Sumenep Madura District. The methods used in this study are mixed because they focus on collecting, analyzing, and mixing quantitative and qualitative data in one study or series of studies.
Pengembangan Usaha Ekonomi Produktif Melalui BUMDes Dalam Mendukung Pemulihan Ekonomi Pedesaan di Kecamatan Konda Kabupaten Konawe Selatan Provinsi Sulawesi Tenggara
Authors: Nur Syamsir , Mas’ud Arifuddin , Suriadi Laode , Tamburaka Sulvariany , Ariani Wa Ode Rachmasari
Published: December 2024

During the pandemic, the village’s economic condition was also depressed due to a decrease in consumer purchasing power (demand side) and disruption to the price and distribution of agricultural production inputs (supply side). Therefore, the recovery of the village economy is directed at maintaining food security, revitalizing Village-Owned Enterprises (BUMDes), digitizing the economy and cash-intensive work programs which are elaborated by considering the potential and various limitations that each village has. BUMDes which have a core business in managing village economic potential, but their ability to play an economic role in the village is still weak, so it needs to be strengthened to bridge the development of local resources, restore the community’s economy, and become a driving force for the village economy. This service activity is carried out to assist the village government and BUMDes managers in mapping village productive economic businesses, developing BUMDES management as well as introducing village development stakeholders in preparing various development planning documents. With this service, the community of village business actors, BUMDes managers and village officials have the same knowledge and understanding regarding business revitalization through BUMDes development. In addition, the need for BUMDes governance training and assistance both from managerial aspects, business unit (operational) aspects and administrative aspects is fulfilled from this community service activity.
Implementasi Personal Branding Dalam Meningkatkan Kredibilitas Jiwa Entrepreneurship Di Era Digital
Authors: Arafah Santi , Miko Jeroh , Syafitri Ema
Published: December 2024

Personal branding is a process of forming public perceptions of aspects owned by individuals, including personality, abilities, values, and stimuli that produce positive perceptions in society, so that they can be used as marketing tools. An entrepreneur really needs good personal branding to build public charm towards themselves so that someone can manage their own life without having to depend on other people. This personal branding is seen from the online representation shown, both spread on websites and social media. The existence of this personal branding can help one’s self-confidence and self-control in achieving achievements as well as self-image that is built through competence and quality possessed.
Implementasi Sistem Persediaan Pada Optik Jasa Pusat
Authors: Maslakha Siti , Agustina Rachma
Published: December 2024

Laporan stok barang adalah laporan yang dibuat untuk mengetahui jumlah stok atau persediaan produk. Kegiatan stok barang di gudang merupakan kegiatan yang menghitung jumlah barang yang tersedia di gudang secara fisik. Untuk melihat dan mendapatkan jumlah persediaan barang yang sesuai pihak perusahaan dapat mengamati dari transaksi penjualan dan dilanjutkan dengan melakukan pengolahan terhadap data penjualan tersebut dengan proses pengolahan terhadap data penjualan ini, perusahaan bisa mendapatkan informasi yang digunakan untuk keperluan pengelolaan persediaan buah seperti mengukur biaya barang yang dipakai berdasarkan harga/biaya barang pada awalnya. Metode masuk pertama keluar pertama atau First In First Out. Dibuat dengan asumsi bahwa barang yang pertama dibeli, barang itu pula yang terlebih dahulu dikeluarkan jika terjadi penjualan. Tetapi dalam akuntansi persediaan, yang diperhitungakan sebagai unsur masukdan keluar tersebut buka fisik tetapi nilai perolehan persediaannya. Untuk menilai barang yang paling terdahulu pembeliannya, dari sekian banyak yang masih ada digudang. Nilai persediaan barang yang masih ada digudang diambil dari harga beli barang yang terakhir dibeli. Metode FIFO dapat dianggap sebagai sebuah pendekatan logis dan realistis terhadap arus biaya terhadap penggunaan metode identifikasi khusus adalah tidak memungkinkan atau tidak praktis. Sistem pencatatan persediaan yang diterapkan di Optik Jasa Pusat yaitu menggunakan Sistem Fisik atau Periodik. Sistem atau metode ini merupakan metode pencatatan persediaan, dimana; Mutasi persediaan tidak menggunakan buku besar inventory melainkan memakai perkiraan pembelian, Tidak memakai kartu persediaan, dan Kalkulasi biaya persediaan dengan cara menetapkan persediaan akhir terlebih dahulu melalui perhitungan secara fisik atau periodik selanjutnya dihitung harga pokok penjualan. Optik Jasa Pusat menggunakan metode penilaian persediaan yaitu metode masuk pertama keluar pertama (FIFO). Metode Masuk Pertama Keluar Pertama (First in First Out) adalah metode yang mengasumsikan bahwa unit yang terjual adalah unit yang terlebih dahulu masuk. FIFO memberikan kesempatan kecil dalam memanipulasi keuntungan karena pembebanan biaya ditentukan oleh urutan terjadinya biaya. Dengan menggunakan kedua metode ini perusahaan mampu menjaga keseimbangan pemasukkan modal dalam perusahaan dan melangsungkan kehidupan perusahaan.
Pelatihan Desain Label Kemasan Dan Pemasaran Online Di Desa Cemandi Sidoarjo
Authors: Widyastuti  , Asandimitra Nadia , Artanti Yessy , Untarini Nindria , Frianto Agus , Tiarawati Monika
Published: December 2024

Desa Cemandi merupakan salah satu desa yang berada di Kabupaten Sidoarjo dan memiliki sejumlah potensi dan salah satunya adalah budidaya Aloe Vera. Tanaman ini dipilih untuk dibudidayakan karena perawatan yang cukup mudah dan cocok dengan iklim serta kondisi tanah di Desa Cemandi. Aloe Vera dapat diolah menjadi bermacam-macam produk, salah satunya adalah diolah menjadi minuman. Minuman Aloe Vera Squash memiliki potensi dan keunggulan yang besar karena memiliki rasa yang segar sehingga diharapkan dapat diterima oleh konsumen. Meskipun produk ini tergolong menarik, namun masih belum dikenal oleh masyarakat sekitar, apalagi masyarakat umum di luar wilayah Desa Cemandi. Program PKM ini ditujukan untuk memberikan solusi terhadap permasalahan yang dihadapi oleh mitra dan berfokus pada pelatihan desain label serta pemasaran online. Pada pelatihan desain label akan diberikan pengetahuan mengenai bagaimana membuat label yang informatif sehingga dapat memberikan informasi sesuai dengan kebutuhan konsumen. Sedangkan untuk pelatihan pemasaran online, peserta akan mendapatkan materi mengenai bagaimana membuat foto yang dapat menarik perhatian konsumen. Melalui pelatihan ini diharapkan pelaku usaha dapat meningkatkan kesadaran masyarakat sekitar akan produk minuman andalannya yaitu minuman Aloe Vera Squash. Dengan meningkatnya kesadaran masyarakat pada akhirnya dapat meningkatkan penjualan minuman Aloe Vera Squash.Aloe Vera
Pembentukan Karakter dan Kreativitas Peserta didik melalui Pelatihan Membuat Buket Bunga di SDN Jombang 2
Authors: Susilo Claudya Zahrani , Asmarani Ratih , Priabudi Danang , Nuruddin Muhammad , Dwinata Anggara
Published: December 2024

Pendidikan memiliki fungsi untuk mengembangkan kemampuan dan membentuk watak serta peradaban bangsa yang bermartabat dalam rangka mencerdaskan kehidupan bangsa. Berdasarkan fungsi inilah pendidikan nasional di Indonesia bertujuan untuk membentuk manusia agar memiliki kecakapan, kreativitas serta kemandirian. Tujuan tersebut dapat tercapai salah satunya melalui pelatihan pembuatan buket bunga. Pelatihan kewirausahaan pembuatan buket bunga ini dilaksanakan untuk menggugah minat peserta didik untuk agar lebih terampil dan memiliki ilmu tentang berwirausaha. Pelatihan pembuatan buket bunga ini diadakan oleh tim dosen PGSD Unhasy berkolaborasi dengan tim AMSP Unhasy yang bertempat di SDN Jombang 2. Kegiatan ini dikemas dalam kegiatan PKM (Pengabdian Kepada Masyarakat), dan yang menjadi sasaran atau peserta adalah peserta didik di SDN Jombang2. Proses kegiatan ini dimulai dengan pemberian materi tentang pemanfaatan bahan limbah kertas, cara berwirausaha serta cara mengubah barang ekonomis menjadi barang yang memiliki nilai jual tinggi. Melalui kegiatan pelatihan ini, diharapkan dapat membentuk karakter dan kreativitas peserta didik
Implementasi Perilaku Manajemen Keuangan Syariah Dalam Mengatasi Masalah Keuangan Di Era Digitalisasi
Authors: Arafah Santi , Miko Jeroh , Ria
Published: December 2024

Perilaku manajemen keuangan syariah adalah kemampuan seseorang dalam mengatur (perencanaan, penganggaran, pemeriksaan, pengelolaan, pengendalian, pencarian, dan penyimpanan) yang sesuai dengan kaidah syariah. Perilaku manajemen keuangan syariah ini sangat diperlukan oleh para remaja Masjid Jami’ Ulayat dalam kehidupan sehari-hari guna dapat memberikan dampak yang positif terutama dalam menghindarkan diri dari sifat boros, hutang dan masalah kesulitan keuangan lainnya. Perilaku manajemen keuangan syariah bertujuan untuk dapat mengendalikan dan mengelola sumber daya keuangan yang ada padanya sesuai dengan kaidah syariah. Namun, hal sebaliknya terjadi jika perilaku manajemen keuangan syariah tidak diterapkan dengan baik, maka akan terjadi kegagalan dalam pengelolaan keuangan.
Implementasi Sistem E-Learning Pada Lembaga Kursus dan Pelatihan di Istikom Jombang
Authors: Sucipto Hadi , Ali Mahrus , Mujianto Ahmad Heru , Kristianto Hery
Published: December 2024

Tujuan Pengabdian Masyarakat ini adalah membuat e-learning yang dirancang untuk kebutuhan e-learning di Lembaga Kursus dan Pelatihan Keterampilan ISTIKOM Jombang dan menyusun aplikasi e-learning yang akan digunakan oleh pengguna yaitu instruktur, staff dan peserta didik berdasarkan skenario pembelajaran online. Metode yang di pakai adalah survey, pembuatan program aplikasi, pelatihan instruktur, staf dan admin lembaga, pengembangan dan testing sistem dan implementasi sistem. Hasil dari pengabdian kepada masyarakat ini adalah aplikasi E-Learning Lembaga Kursus dan Pelatihan berbasis web
Sosialisasi Pengenalan Lembaga Keuangan Syariah Bagi Generasi Millenial Dalam Berinvestasi Syariah
Authors: Arafah Santi
Published: December 2024

Pengabdian masyarakat yang dilakukan di MAS Taman Pendidikan Islam Medan bertujuan untuk mendidik dan membimbing siswa/i untuk berpikir secara ekonomi, berperilaku bisnis dan meningkatkan kualitas hidup mereka dengan cara berinvestasi secara syariah baik melalui lembaga bank syariah maupun lembaga non bank syariah. Lembaga keuangan syariah adalah sebuah badan usaha yang kegiatannya di bidang keuangan syariah dan asetnya berupa keuangan maupun non keuangan berdasarkan prinsip syariah Islam. Setiap kegiatan operasional di dalamnya tidak boleh mengandung unsur riba ataupun unsur yang dilarang dalam agama Islam. Metode pelaksanaan kegiatan yang dilakukan dalam pengabdian ini berupa metode pengajaran yang dilakukan di dalam kelas XII siswa/i MAS Taman Pendidikan Islam berupa pengajaran/ceramah, tanya jawab dan Focus Discussion Group (FDG). Pengenalan lembaga keuangan syariah bagi generasi millennial dalam berinvestasi syariah terutama pada siswa/i MAS Taman Pendidikan Islam berhasil dipahami oleh siswa/i XII MAS Taman Pendidikan Islam. Dimana, lembaga keuangan syariah memiliki peranan penting dalam pembangunan ekonomi suatu negara, dikarenakan dengan bertambahnya modal yang dihimpun dalam suatu periode oleh suatu perekonomian akan dapat menaikkan pendapatan nasional dan kesempatan kerja bagi perekonomian tersebut.
Pelatihan Pengembangan Media Pembelajaran ChatGPT Berbasis Artificial Intelegence pada SMK Bina Jaya Palembang
Authors: Sayuti Akhmad , Ardiansyah Muhammad Ridho , Davizan Serry , Harist Abdul , Irwansyah
Published: December 2024

Pengabdian ini bertujuan untuk memperkenalkan dan melatih penggunaan ChatGPT sebagai media pembelajaran berbasis kecerdasan buatan (AI) di SMK Bina Jaya Palembang. Pelatihan ini dirancang untuk meningkatkan kualitas pembelajaran dengan memanfaatkan teknologi AI guna mendukung siswa dan guru dalam proses belajar mengajar yang lebih interaktif dan efektif. Metode yang digunakan meliputi ceramah, diskusi, simulasi, dan praktik langsung, yang diikuti oleh evaluasi untuk mengukur peningkatan pemahaman peserta. Hasil kegiatan menunjukkan antusiasme tinggi dari guru dan siswa dalam memanfaatkan ChatGPT, dengan peningkatan signifikan pada keterampilan literasi digital dan kemampuan merancang media pembelajaran. Namun, keterbatasan seperti waktu praktik yang kurang dan tingkat literasi digital yang bervariasi menjadi tantangan yang perlu diatasi. Implikasi dari kegiatan ini adalah perlunya pelatihan lanjutan untuk mendukung penerapan teknologi AI secara berkelanjutan dalam dunia pendidikan, terutama di lingkungan sekolah menengah kejuruan.
Pengenalan Olahraga Tradisional Gobak Sodor Untuk Meningkatkan Kekompakan Pada Siswa dan Siswi di MI Ma’arif Gogik Ungaran
Authors: Maulana Muhammad Ardan , Setiawan Fredy Eko , Aristiyanto  , Herdinata Guntur R.P
Published: December 2024

Kegiatan pengabdian ini bertujuan untuk memperkenalkan permainan tradisional Gobak Sodor kepada siswa-siswi MI Ma’arif Gogik Ungaran sebagai upaya meningkatkan kekompakan. Metode yang digunakan mencakup sosialisasi, pelatihan, dan praktik langsung. Dalam sosialisasi, siswa diperkenalkan dengan sejarah, manfaat, dan aturan permainan Gobak Sodor. Pada pelatihan, siswa dipandu untuk memahami dan menguasai strategi permainan. Tahap praktik melibatkan pembagian siswa menjadi tim untuk mempraktikkan keterampilan yang telah diajarkan. Hasil pengabdian menunjukkan bahwa permainan ini efektif dalam meningkatkan kekompakan, kerjasama, dan kemampuan fisik siswa. Selain itu, siswa menjadi lebih antusias untuk melestarikan olahraga tradisional.
Optimalisasi Manajemen Sumber Daya Manusia Untuk Mendukung Koperasi dan UMKM Berbasis Potensi Lokal Kabupaten Seluma Bengkulu
Authors: Dewi Ratih Komala
Published: December 2024

Pengabdian masyarakat ini bertujuan mengoptimalkan manajemen sumber daya manusia (SDM) untuk mendukung koperasi dan UMKM berbasis potensi lokal di Kabupaten Seluma, Bengkulu. Dengan pendekatan partisipatif, kegiatan ini meliputi pelatihan manajemen SDM, peningkatan keterampilan operasional bisnis, serta pendampingan dan dukungan langsung kepada pelaku usaha. Evaluasi menunjukkan peningkatan pemahaman dan keterampilan peserta dalam pengelolaan usaha, dengan 80% peserta merasa lebih percaya diri setelah pelatihan. Hasil program ini menciptakan koperasi dan UMKM yang lebih profesional dan berdaya saing, mendukung pertumbuhan ekonomi lokal. Implikasi dari pengabdian ini adalah pentingnya penguatan kapasitas SDM dan inovasi berbasis potensi lokal untuk keberlanjutan usaha di daerah pedesaan.
Diverse perspectives on proteomic posttranslational modifications to address EGFR-TKI resistance in non-small cell lung cancer
Authors: Ma Yuhong , Zhang Feng , Li Jin , Li Juan , Li Yanhua
Published: December 2024

Non-small cell lung cancer (NSCLC) is the main histological subtype of lung cancer. For locally advanced and advanced NSCLC, epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI)-targeted therapy has been the first choice for NSCLC patients with EGFR mutations. TKIs, as targeted drugs, inhibit kinase activity and autophosphorylation by competitively binding to the ATP binding site of the EGFR tyrosine kinase domain, which blocks the signal transduction mediated by EGFR and thus inhibits the proliferation of tumor cells. However, drug resistance to TKIs is inevitable. EGFR is also a highly glycosylated receptor tyrosine kinase, and a wide range of crosstalk occurs between phosphorylation and glycosylation. Therefore, can the phosphorylation state be altered by glycosylation to improve drug resistance? In this review, we summarize phosphorylation, glycosylation and the crosstalk between these processes as well as the current research status and methods. We also summarize the autophosphorylation and glycosylation sites of the EGFR protein and their crosstalk. By exploring the relationship between EGFR glycosylation and autophosphorylation in targeted TKI therapy, we find that research on EGFR glycosylation is crucial for targeted NSCLC treatment and will become a research direction for identifying potential targets related to regulating TKI drug sensitivity.
ISG15–LFA1 interactions in latent HIV clearance: mechanistic implications in designing antiviral therapies
Authors: Koka Prasad S. , Ramdass Bharathi
Published: December 2024

Interferon types-I/II (IFN-αβ/γ) secretions are well-established antiviral host defenses. The human immunodeficiency virus (HIV) particles are known to prevail following targeted cellular interferon secretion. CD4+ T-lymphocytes are the primary receptor targets for HIV entry, but the virus has been observed to hide (be latent) successfully in these cells through an alternate entry route via interactions with LFA1. HIV facilitates its post-entry latency-driven mode of hiding through these interactions to displace or inhibit ISG15 by forming the HIV1-LFA1 complex in lieu of ISG15-LFA1, which would at least transiently halt and bypass type-I IFN secretion. This could explain why the elimination of HIV from cellular hideouts is difficult. Hence, HIV clearance needs to be addressed to reverse its latency in LFA1+ T-lymphocytes and CD34+/CD133+ early progenitor stem cells. In the context of hematopoietic or endothelial stem-progenitor cells (HSPC/ESPC), we discuss the potential role of LFA1 in HIV permissiveness and latency in LFA1-CD34+/CD133+ versus LFA1+CD34+/CD133+ HSPCs/ESPCs. In HIV latency, the viral particles may remain engaged on the naïve-resting cells’ LFA1, which are then unable to accommodate the ISG15 molecules owing to conformational changes induced upon occupation by the virus at the ISG15-LFA1 binding or interaction sites through halting of the subsequent downstream type-II IFN secretion. Viral binding to LFA1, including its transfer through activated-naïve cell–cell contacts may be a key step that needs to be addressed to prevent “transient or partial” virus-induced shutdown of type-I IFN secretion. This process allows an alternate viral entry and hideout site via LFA1. The subsequent administration of recombinant ISG15 may ensure sufficient type I/II IFN release to promote, enhance, or sustain the innate immune responses. Thus, combination antiviral therapies could potentially include exogenous ISG15 to maintain or sustain biologically and clinically relevant ISG15-LFA1 interactions. In addition to alternating with co-challenges of PKC-pro-LRA-drug modulators, this is administered post (antiretroviral therapy) and continued with periodic ART until permanent elimination of viral resurgence and latency is achieved in patients with HIV/AIDS. This triple-combination drug regimen is expected to pave the path for systemic virus clearance in vivo.
Effects of advanced glycation end products on stem cell
Authors: Zheng Zetai , Zhou Hui , Zhang Wenwen , Wang Tingyu , Swamiappan Sathiskumar , Peng Xinsheng , Zhou Yanfang
Published: December 2024

In recent years, stem cell therapy has become a pivotal component of regenerative medicine. Stem cells, characterized by their self-renewal capacity and multidirectional differentiation potential, can be isolated from a variety of biological tissues, including adipose tissue, bone marrow, the umbilical cord, and the placenta. The classic applications of stem cells include human pluripotent stem cells (hPSCs) and mesenchymal stem cells (MSCs). However, numerous factors can influence the normal physiological function of stem cells. For instance, in diabetes mellitus, advanced glycation end products (AGEs) accumulate in the extracellular matrix (ECM), impairing the physiological function of stem cells. These substances are closely associated with aging and the progression of numerous degenerative diseases. AGEs can create an environment that is detrimental to the normal physiological functions of stem cells. By binding to the primary cellular receptor for advanced glycation end products (RAGE), AGEs disrupt the physiological activities of stem cells. The binding of RAGE to various ligands triggers the activation of downstream signaling pathways, contributing to the pathophysiological development of diabetes, aging, neurodegenerative diseases, and cancer. Therefore, there is an urgent need for comprehensive research on the impact of AGEs on stem cells, which could provide new insights into the therapeutic application of stem cells in regenerative medicine.
Recent advances in gut microbiota and thyroid disease: pathogenesis and therapeutics in autoimmune, neoplastic, and nodular conditions
Authors: Fang Lihua , Ning Jie
Published: December 2024

This review synthesizes key findings from the past five years of experimental literature, elucidating the gut microbiome’s significant influence on the pathogenesis of thyroid diseases. A pronounced shift in the gut microbiota composition has been consistently observed, with a significant reduction in bacteria such as Bifidobacterium, Bacillaceae, Megamonas, and Clostridium, and a notable increase in bacteria, including Bacteroides, Proteobacteria, Actinobacteria, Desulfobacterota, and Klebsiella. These alterations are implicated in the development and progression of thyroid diseases by impacting metabolic pathways including bile acid and cytokine production, including a decrease in short-chain fatty acids (SCFAs) that are crucial for immune regulation and thyroid hormone homeostasis. The review also highlights the therapeutic implications of probiotics in managing thyroid conditions. Evidence suggests that probiotic adjunct therapy can modulate the gut microbiota, leading to improvements in thyroid function and patient outcomes. The use of specific probiotic strains, such as Lactiplantibacillus plantarum 299v and Bifidobacterium longum, has demonstrated potential in enhancing the effects of traditional treatments and possibly restoring a balanced gut microbiota. Notably, fecal microbiota transplantation (FMT) has emerged as a promising intervention in Graves’ Disease (GD), demonstrating the potential to recalibrate the gut microbiota, thereby influencing neurotransmitters and trace elements via the gut-brain and gut-thyroid axes. The integration of microbiome-based therapies with traditional treatments is anticipated to usher in a new era of personalized thyroid disease management, offering a more nuanced approach to patient care. By integrating this body of work, the review offers an innovative perspective on the gut microbiome’s broad impact on thyroid diseases and the therapeutic applications of probiotics.
In-depth exploration and application of fracturing construction curves in fractured tight sandstone reservoirs of the Tarim Basin
Authors: Cai Mingjin , Zhang Haofei , Qiang Jianli , Wang Zhimin , Yin Guoqing , Xie Chaoqun , Chen Keyou , Xi Haojiang
Published: December 2024

Fractured tight sandstone reservoirs are representative reservoirs in the Tarim Basin, characterized by the development of natural fractures and diverse interaction modes between artificial and natural fractures. The complex shape of the construction pressure curves during fracturing makes it difficult for existing fracture extension diagnosis methods to provide effective guidance. To thoroughly explore the information contained in the construction curves and accurately characterize hydraulic fracturing parameters, this study proposes a dynamic bottomhole net pressure calculation method based on real-time fracturing construction data, allowing for more precise correction of the bottomhole net pressure. Subsequently, a fracture extension mode recognition mechanism for fractured tight sandstone reservoirs is established, identifying five modes of fracture extension: activation of natural fractures, restricted extension, complex fracture extension, communication with natural fractures, and vertical penetration of fractures. The concept of a post-fracturing complex fracture network index is introduced, leading to a comprehensive method for diagnosing and recognizing construction pressure curves suitable for fractured tight sandstone reservoirs. Field case studies indicate that: (1) the ability of artificial fractures to activate natural fractures and form complex fractures is closely related to net pressure; (2) when the net pressure curve exhibits periodic trends, natural fractures within the reservoir may branch and redirect, forming more complex multi-stage fractures; (3) a higher complex fracture network index post-fracturing corresponds to a higher unimpeded flow capacity, indicating better production enhancement effects. The conclusion suggests that this fracture recognition method can enhance the fracturing potential of fractured tight sandstone reservoirs and is significant for guiding real-time dynamic adjustments in field fracturing operations.
Exploratory miRNA profiling from serum and bone tissue of mice with T1D-induced bone loss
Authors: Daamouch Souad , Diendorfer Andreas , Hackl Matthias , Christoffel Gabriele , Hofbauer Lorenz C. , Rauner Martina
Published: December 2024

Type 1 diabetes (T1D) represents a significant health burden worldwide, with associated complications including bone fragility. Current clinical methods and biomarkers for assessing bone health and predicting fracture risk in T1D are limited and lack accuracy. MicroRNAs (miRNAs) have emerged as potential biomarkers for predicting T1D-induced bone loss, although comprehensive profiling studies are lacking. Previous investigations have indicated a link between dysregulated miRNA expression levels and impaired bone health in T1D. Therefore, in this study, we explored differential miRNA expression levels in serum and bone tissue of mice with T1D-induced bone loss using Next Generation Sequencing (NGS). T1D was induced using streptozotocin in male wild-type mice. Serum and bone tissues were analyzed at 14 weeks of age, following the prior characterization of bone loss in this mouse model. MiRNA profiling was conducted using two-independent NGS analyses and validated through quantitative RT-PCR. NGS profiling identified differential expression of miRNAs in serum and bone tissue of T1D mice compared to controls. The first NGS analysis revealed 24 differentially expressed miRNAs in serum and 13 in bone tissue. Especially, miR-136-3p was consistently downregulated in both serum and bone tissue. However, the second NGS analysis presented a distinct set of dysregulated miRNAs, with miR-206-3p overlapping in both tissues but exhibiting differential expression patterns. Surprisingly, miR-144-5p, miR-19a-3p, and miR-21a-5p displayed contrasting regulatory patterns between NGS and qPCR analyses. Finally, gene network analysis identified associations between dysregulated miRNAs and pathways involved in bone physiology, including TGF-beta, PI3-Akt signaling, and osteoclast differentiation in humans. In conclusion, our study offers initial insights into dysregulated miRNAs associated with T1D-induced bone loss, but also highlights the lack of consistency in the results obtained from miRNA sequencing in different cohorts. Thus, further investigation is needed to better understand the complexities of miRNA analyses before they can be established as reproducible biomarkers for predicting bone health in T1D.
Perfluorinated compounds linked to central precocious puberty in girls during COVID-19: an untargeted metabolomics study
Authors: Li Haidan , Xie Manfang , Luo Hailing , Cai Yuhua , Liu Li , Li Hongai , Hai Yuanping , Ren Yi , Xue Jing , He Xiaojie , Huang Xiaoyan , Xiang Wei
Published: December 2024

Background and objective

The incidence of central precocious puberty (CPP) in girls increased significantly during the COVID-19 pandemic. This study aimed to explore the impact of perfluorinated endocrine disruptors on CPP through metabolomics analysis in girls from Hainan Province, China.

Methods

Serum samples from 100 girls with CPP and 100 healthy controls were collected. Untargeted metabolomics profiling was performed using ultra-high performance liquid chromatography coupled with quadrupole-Exactive Orbitrap mass spectrometry (UHPLC-Q-Exactive-Orbitrap-MS). Differentially expressed metabolites (DEMs) were screened, and pathway enrichment analysis was conducted.

Results

Principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) revealed distinct metabolic profiles between the CPP and control groups. A total of 511 metabolites were identified, including 296 up-regulated DEMs and 255 down-regulated DEMs. Three perfluorinated compounds—PFSM-perfluoroalkyl_sulfonamide_Me, PFSM-FSAA, and PFCA-unsaturated—were significantly upregulated in the CPP group. KEGG pathway enrichment analysis suggested the involvement of multiple pathways in the CPP process regulated by these compounds.

Conclusions

Perfluorinated compounds may promote CPP in girls by interfering with various pathways and affecting the hypothalamic-pituitary-gonadal axis function. This study highlighted the need for further research and public health measures to address environmental endocrine disruptors.
Evaluating local livelihoods, sustainable forest management, and the potential for ecotourism development in Kaimur Wildlife Sanctuary, India
Authors: Bhushan Shashi , Dincă Iulian , Shikha Shalini
Published: December 2024

Effective forest management in India must address the economic needs of local communities, often displaced by restrictive policies. These marginalized local communities, despite their traditional knowledge, lack alternative income sources, necessitating integration into management or exploration of options like ecotourism. Recognized for balancing conservation and livelihood support, ecotourism offers a viable solution to enhance economic opportunities while conserving resources. This paper explores ecotourism’s potential to boost local economies and examines how current management practices and alternative livelihoods can address resource scarcity in Kaimur Wildlife Sanctuary, India. The study employed a combination of qualitative research methods, including semi-structured interviews, surveys, on-site observations, focus group discussions, and literature reviews, along with a cross-sectional survey approach that integrated both qualitative and quantitative data collection to provide comprehensive insights. The study reveals that impoverished communities near forests, reliant on indigenous knowledge and resources, have been severely affected by forest degradation and current management practices. The findings highlight community-based ecotourism as a promising solution for sustainable income generation in the region, helping to mitigate resource degradation and support sustainable development. However, the region’s ecotourism potential is hindered by inadequate infrastructure, training & opportunities, and public awareness. Developing ecotourism as an alternative income source, alongside an inclusive forest management strategy that integrates social diversity, livelihood generation, and conservation, is essential for promoting nature conservation, reducing poverty, and enhancing the well-being of local communities. Strengthening non-agricultural livelihoods and preserving indigenous knowledge through ecotourism is crucial for effective resource management, while the study underscores the importance of community involvement in forest governance, offering valuable insights for policymakers and conservationists in developing sustainable management strategies.
Novel rhesus macaque immunoglobulin germline genes identified by three sequencing approaches
Authors: Guo Yicheng , Waltari Eric , Lu Hong , Sheng Zizhang , Wu Xueling
Published: December 2024

Introduction

Rhesus macaques have long been a focus of research for understanding immune responses to human pathogens due to their close phylogenetic relationship with humans. As rhesus macaque antibody germlines show high degrees of polymorphism, the spectrum of database-covered genes expressed in individual macaques remains to be determined.

Methods

Here, four rhesus macaques infected with SHIVSF162P3N became a study of interest because they developed broadly neutralizing antibodies against HIV-1. To identify the immunoglobulin heavy chain V-gene (IGHV) germlines in these macaques, we applied three sequencing approaches – genomic DNA (gDNA) TOPO sequencing, gDNA MiSeq, and messenger RNA (mRNA) MiSeq inference with IgDiscover, and illustrated the detection power of each method.

Results

Of the 197 new rhesus IGHV germline sequences identified, 116 (59%) were validated by at least two methods, and 143 (73%) were found in at least two macaques or two sample sources. About 20% of germlines in each macaque are missing from the current database, including a subset frequently expressed. Overall, gDNA MiSeq determined the greatest number of germline sequences, followed by gDNA TOPO sequencing and mRNA MiSeq inference by IgDiscover, with IgDiscover providing direct evidence of allele expression and usage.

Discussion

Our interdisciplinary study sheds light on germline sequencing, enhances the rhesus IGHV germline database, and highlights the importance of germline sequencing in rhesus immune repertoire studies.