bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 2 from Regulatory T-cell Response to Enterotoxigenic Bacteroides fragilis Colonization Triggers IL17-Dependent Colon Carcinogenesis
Authors: Geis Abby L. , Fan Hongni , Wu Xinqun , Wu Shaoguang , Huso David L. , Wolfe Jaime L. , Sears Cynthia L. , Pardoll Drew M. , Housseau Franck
Published: April 2023

IL-17+ Foxp3+ Tregs infiltrate ETBF-infected colons. Min mice were inoculated with ETBF on day 0. At 10 weeks, colonic LPLs were harvested from colon tumors (left) and adjacent non-tumor colon tissue (right). Cells were stimulated ex vivo, followed by ICS. Dot plots show viable CD4+ LPLs. Percentage of IL-17+ within Foxp3+ gate is indicated.
Supplementary Table 4 from A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity
Authors: Grabiner Brian C. , Nardi Valentina , Birsoy Kıvanç , Possemato Richard , Shen Kuang , Sinha Sumi , Jordan Alexander , Beck Andrew H. , Sabatini David M.
Published: April 2023

XLSX file 12K, All activating MTOR mutations from this study are listed
Supplementary Table 3 from A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity
Authors: Grabiner Brian C. , Nardi Valentina , Birsoy Kıvanç , Possemato Richard , Shen Kuang , Sinha Sumi , Jordan Alexander , Beck Andrew H. , Sabatini David M.
Published: April 2023

XLSX file 10K, Homologous mutations from S. pombe tor2 in H. sapiens MTOR are listed
Supplementary Table 2 from A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity
Authors: Grabiner Brian C. , Nardi Valentina , Birsoy Kıvanç , Possemato Richard , Shen Kuang , Sinha Sumi , Jordan Alexander , Beck Andrew H. , Sabatini David M.
Published: April 2023

XLSX file 31K, All MTOR mutations from a literature search and the cBIO, COSMIC, and ICGC databases are listed
Supplementary Figure 6 from Inflammation-Induced NFATc1–STAT3 Transcription Complex Promotes Pancreatic Cancer Initiation by KrasG12D
Authors: Baumgart Sandra , Chen Nai-Ming , Siveke Jens T. , König Alexander , Zhang Jin-San , Singh Shiv K. , Wolf Elmar , Bartkuhn Marek , Esposito Irene , Heßmann Elisabeth , Reinecke Johanna , Nikorowitsch Julius , Brunner Marius , Singh Garima , Fernandez-Zapico Martin E. , Smyrk Thomas , Bamlet William R. , Eilers Martin , Neesse Albrecht , Gress Thomas M. , Billadeau Daniel D. , Tuveson David , Urrutia Raul , Ellenrieder Volker
Published: April 2023

PDF file 3772K, Supplementary Figure refers to Figure 6 and displays additional data on NFATc1 knockout mice
Supplementary Figure 3 from A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity
Authors: Grabiner Brian C. , Nardi Valentina , Birsoy Kıvanç , Possemato Richard , Shen Kuang , Sinha Sumi , Jordan Alexander , Beck Andrew H. , Sabatini David M.
Published: April 2023

PDF file 94K,Non-recurrent MTOR mutations confer different degrees of mTORC1 activation
Supplementary Figure 1 from A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity
Authors: Grabiner Brian C. , Nardi Valentina , Birsoy Kıvanç , Possemato Richard , Shen Kuang , Sinha Sumi , Jordan Alexander , Beck Andrew H. , Sabatini David M.
Published: April 2023

PDF file 85K, mTOR pathway mutations
Supplementary Figure 2 from Inflammation-Induced NFATc1–STAT3 Transcription Complex Promotes Pancreatic Cancer Initiation by KrasG12D
Authors: Baumgart Sandra , Chen Nai-Ming , Siveke Jens T. , König Alexander , Zhang Jin-San , Singh Shiv K. , Wolf Elmar , Bartkuhn Marek , Esposito Irene , Heßmann Elisabeth , Reinecke Johanna , Nikorowitsch Julius , Brunner Marius , Singh Garima , Fernandez-Zapico Martin E. , Smyrk Thomas , Bamlet William R. , Eilers Martin , Neesse Albrecht , Gress Thomas M. , Billadeau Daniel D. , Tuveson David , Urrutia Raul , Ellenrieder Volker
Published: April 2023

PDF file 2319K, Supplementary Figure 2 refers to Figure 2 and displays further information about KrasG12D;NFATc1 mice
Supplementary Table S1 from HER2 Activating Mutations Are Targets for Colorectal Cancer Treatment
Authors: Kavuri Shyam M. , Jain Naveen , Galimi Francesco , Cottino Francesca , Leto Simonetta M. , Migliardi Giorgia , Searleman Adam C. , Shen Wei , Monsey John , Trusolino Livio , Jacobs Samuel A. , Bertotti Andrea , Bose Ron
Published: April 2023

Gene sequencing and MSI Status of Patients and PDX's.
Supplementary Figures from Autophagy Opposes p53-Mediated Tumor Barrier to Facilitate Tumorigenesis in a Model of PALB2-Associated Hereditary Breast Cancer
Authors: Huo Yanying , Cai Hong , Teplova Irina , Bowman-Colin Christian , Chen Guanghua , Price Sandy , Barnard Nicola , Ganesan Shridar , Karantza Vassiliki , White Eileen , Xia Bing
Published: April 2023

Supplementary Figures - PDF file 1145K, These supplementary figures (Fig. S1-S5) show the results of additional analyses of Palb2-null tumors and drived cells
Supplementary Table S5 from RNA Helicase A Is a Downstream Mediator of KIF1Bβ Tumor-Suppressor Function in Neuroblastoma
Authors: Chen Zhi Xiong , Wallis Karin , Fell Stuart M. , Sobrado Veronica R. , Hemmer Marie C. , Ramsköld Daniel , Hellman Ulf , Sandberg Rickard , Kenchappa Rajappa S. , Martinson Tommy , Johnsen John I. , Kogner Per , Schlisio Susanne
Published: April 2023

PDF file 81K, Table S5, related to Discussion Summary of DHX9 mutations found extracted from Catalogue of Somatic Mutations in Cancer database (COSMIC)
Supplementary Table S4 from RNA Helicase A Is a Downstream Mediator of KIF1Bβ Tumor-Suppressor Function in Neuroblastoma
Authors: Chen Zhi Xiong , Wallis Karin , Fell Stuart M. , Sobrado Veronica R. , Hemmer Marie C. , Ramsköld Daniel , Hellman Ulf , Sandberg Rickard , Kenchappa Rajappa S. , Martinson Tommy , Johnsen John I. , Kogner Per , Schlisio Susanne
Published: April 2023

PDF file 107K, Table S4, related to Table 1. KIF1B mutation reports in neuroblastoma tumors K14 and K10
Supplementary Figure S3 from Induction of Telomere Dysfunction Mediated by the Telomerase Substrate Precursor 6-Thio-2′-Deoxyguanosine
Authors: Mender Ilgen , Gryaznov Sergei , Dikmen Z. Gunnur , Wright Woodring E. , Shay Jerry W.
Published: April 2023

Liver, renal spleen and colon effect.
Supplementary Figure 7 from RNA Helicase A Is a Downstream Mediator of KIF1Bβ Tumor-Suppressor Function in Neuroblastoma
Authors: Chen Zhi Xiong , Wallis Karin , Fell Stuart M. , Sobrado Veronica R. , Hemmer Marie C. , Ramsköld Daniel , Hellman Ulf , Sandberg Rickard , Kenchappa Rajappa S. , Martinson Tommy , Johnsen John I. , Kogner Per , Schlisio Susanne
Published: April 2023

PDF file 1540K, Figure S7, related to Figure 7G and Discussion. Model proposing mechanism of KIF1Bβ mediated apoptosis in a developing neuroblast competing for limiting trophic factor NGF
Supplementary Figure S2 from Induction of Telomere Dysfunction Mediated by the Telomerase Substrate Precursor 6-Thio-2′-Deoxyguanosine
Authors: Mender Ilgen , Gryaznov Sergei , Dikmen Z. Gunnur , Wright Woodring E. , Shay Jerry W.
Published: April 2023

Hematology.
Supplementary Figure 3 from RNA Helicase A Is a Downstream Mediator of KIF1Bβ Tumor-Suppressor Function in Neuroblastoma
Authors: Chen Zhi Xiong , Wallis Karin , Fell Stuart M. , Sobrado Veronica R. , Hemmer Marie C. , Ramsköld Daniel , Hellman Ulf , Sandberg Rickard , Kenchappa Rajappa S. , Martinson Tommy , Johnsen John I. , Kogner Per , Schlisio Susanne
Published: April 2023

PDF file 4071K, Figure S3, related to Figure 3. KIF1Bbeta promotes DHX9 nuclear localization
Supplementary Table 2 from Defective Stromal Remodeling and Neutrophil Extracellular Traps in Lymphoid Tissues Favor the Transition from Autoimmunity to Lymphoma
Authors: Sangaletti Sabina , Tripodo Claudio , Vitali Caterina , Portararo Paola , Guarnotta Carla , Casalini Patrizia , Cappetti Barbara , Miotti Silvia , Pinciroli Patrizia , Fuligni Fabio , Fais Franco , Piccaluga Pier Paolo , Colombo Mario P.
Published: April 2023

PDF file 62K, List of inflammatory up and down modulated genes in SPARC high human B-NHLs
Supplementary Table S3 from Reduced NF1 Expression Confers Resistance to EGFR Inhibition in Lung Cancer
Authors: de Bruin Elza C. , Cowell Catherine , Warne Patricia H. , Jiang Ming , Saunders Rebecca E. , Melnick Mary Ann , Gettinger Scott , Walther Zenta , Wurtz Anna , Heynen Guus J. , Heideman Daniëlle A.M. , Gómez-Román Javier , García-Castaño Almudena , Gong Yixuan , Ladanyi Marc , Varmus Harold , Bernards René , Smit Egbert F. , Politi Katerina , Downward Julian
Published: April 2023

PDF file 84K, Table S3. Summary of the individual murine tumors with treatment response
Supplementary Figure 2 from Biallelic Deleterious BRCA1 Mutations in a Woman with Early-Onset Ovarian Cancer
Authors: Domchek Susan M. , Tang Jiangbo , Stopfer Jill , Lilli Dana R. , Hamel Nancy , Tischkowitz Marc , Monteiro Alvaro N.A. , Messick Troy E. , Powers Jacquelyn , Yonker Alexandria , Couch Fergus J. , Goldgar David E. , Davidson H. Rosemarie , Nathanson Katherine L. , Foulkes William D. , Greenberg Roger A.
Published: April 2023

Supplementary Figure 2 PDF file 78K, This figure depicts the assay used to visualize repair proteins at DNA double-strand breaks
Supplementary Figure 1 from Biallelic Deleterious BRCA1 Mutations in a Woman with Early-Onset Ovarian Cancer
Authors: Domchek Susan M. , Tang Jiangbo , Stopfer Jill , Lilli Dana R. , Hamel Nancy , Tischkowitz Marc , Monteiro Alvaro N.A. , Messick Troy E. , Powers Jacquelyn , Yonker Alexandria , Couch Fergus J. , Goldgar David E. , Davidson H. Rosemarie , Nathanson Katherine L. , Foulkes William D. , Greenberg Roger A.
Published: April 2023

Supplementary Figure 1 PDF file 108K, This document provides the raw data for V1736A genotyping used in LOH experiments
Supplementary Table S2 from Intratumoral Heterogeneity in a Trp53-Null Mouse Model of Human Breast Cancer
Authors: Zhang Mei , Tsimelzon Anna , Chang Chi-Hsuan , Fan Cheng , Wolff Andrew , Perou Charles M. , Hilsenbeck Susan G. , Rosen Jeffrey M.
Published: April 2023

Supplementary Table S2. A detailed explanation for mice used in Table 1.
Supplementary Table 2 from Succinate Dehydrogenase Mutation Underlies Global Epigenomic Divergence in Gastrointestinal Stromal Tumor
Authors: Killian J. Keith , Kim Su Young , Miettinen Markku , Smith Carly , Merino Maria , Tsokos Maria , Quezado Martha , Smith William I. , Jahromi Mona S. , Xekouki Paraskevi , Szarek Eva , Walker Robert L. , Lasota Jerzy , Raffeld Mark , Klotzle Brandy , Wang Zengfeng , Jones Laura , Zhu Yuelin , Wang Yonghong , Waterfall Joshua J. , O'Sullivan Maureen J. , Bibikova Marina , Pacak Karel , Stratakis Constantine , Janeway Katherine A. , Schiffman Joshua D. , Fan Jian-Bing , Helman Lee , Meltzer Paul S.
Published: April 2023

Supplementary Table 2 XLSX file 490K, Illumina GoldenGate Methylation Standard Cancer Panel I Target CpG Annotations and differential methylation significance values for group comparisons listed in Table
Supplementary Figure 1 from Succinate Dehydrogenase Mutation Underlies Global Epigenomic Divergence in Gastrointestinal Stromal Tumor
Authors: Killian J. Keith , Kim Su Young , Miettinen Markku , Smith Carly , Merino Maria , Tsokos Maria , Quezado Martha , Smith William I. , Jahromi Mona S. , Xekouki Paraskevi , Szarek Eva , Walker Robert L. , Lasota Jerzy , Raffeld Mark , Klotzle Brandy , Wang Zengfeng , Jones Laura , Zhu Yuelin , Wang Yonghong , Waterfall Joshua J. , O'Sullivan Maureen J. , Bibikova Marina , Pacak Karel , Stratakis Constantine , Janeway Katherine A. , Schiffman Joshua D. , Fan Jian-Bing , Helman Lee , Meltzer Paul S.
Published: April 2023

Supplementary Figure 1 - PDF file 1233K, Supplemental Figure 1: Representative array comparative genomic hybridization (aCGH) results of genomic copy number near-normal GIST (left column, n=5) and genomic copy number abnormal GIST (right column, n=5) (Agilent 180K catalogue assay)
Supplementary Figure S1 from Intratumoral Heterogeneity in a Trp53-Null Mouse Model of Human Breast Cancer
Authors: Zhang Mei , Tsimelzon Anna , Chang Chi-Hsuan , Fan Cheng , Wolff Andrew , Perou Charles M. , Hilsenbeck Susan G. , Rosen Jeffrey M.
Published: April 2023

Supplementary Figure S1. Genetic characterization of the four individual subpopulations (PCR and CGH analysis).
Supplementary Table and Figure Legends from Parallel RNA Interference Screens Identify EGFR Activation as an Escape Mechanism in FGFR3-Mutant Cancer
Authors: Herrera-Abreu Maria Teresa , Pearson Alex , Campbell James , Shnyder Steve D. , Knowles Margaret A. , Ashworth Alan , Turner Nicholas C.
Published: April 2023

Supplementary Table and Figure Legends - PDF file 77K, Supplementary table and figure legends
Supplementary Figure S5 from Promotion of Colorectal Cancer Invasion and Metastasis through Activation of NOTCH–DAB1–ABL–RHOGEF Protein TRIO
Authors: Sonoshita Masahiro , Itatani Yoshiro , Kakizaki Fumihiko , Sakimura Kenji , Terashima Toshio , Katsuyama Yu , Sakai Yoshiharu , Taketo M. Mark
Published: April 2023

Supplementary Fig. S5 shows Trio phosphorylation caused by activation of Notch signaling.
Supplementary Figure S3 from Promotion of Colorectal Cancer Invasion and Metastasis through Activation of NOTCH–DAB1–ABL–RHOGEF Protein TRIO
Authors: Sonoshita Masahiro , Itatani Yoshiro , Kakizaki Fumihiko , Sakimura Kenji , Terashima Toshio , Katsuyama Yu , Sakai Yoshiharu , Taketo M. Mark
Published: April 2023

Supplementary Fig. S3 shows that Rho promotes transendothelial migration (TEM) of CRC cells.
Supplementary Figure 4 from Parallel RNA Interference Screens Identify EGFR Activation as an Escape Mechanism in FGFR3-Mutant Cancer
Authors: Herrera-Abreu Maria Teresa , Pearson Alex , Campbell James , Shnyder Steve D. , Knowles Margaret A. , Ashworth Alan , Turner Nicholas C.
Published: April 2023

Supplementary Figure 4 - PDF file 354K, Analysis of the effects on combined EGFR and FGFR3 inhibition, and mechanism of EGFR upregulation by FGFR inhibitors
Supplementary Figure 3 from Parallel RNA Interference Screens Identify EGFR Activation as an Escape Mechanism in FGFR3-Mutant Cancer
Authors: Herrera-Abreu Maria Teresa , Pearson Alex , Campbell James , Shnyder Steve D. , Knowles Margaret A. , Ashworth Alan , Turner Nicholas C.
Published: April 2023

Supplementary Figure 3 - PDF file 87K, Analysis of cell cycle and apoptosis of FGFR and EGFR combination inhibition
Supplementary Figure S1 from Promotion of Colorectal Cancer Invasion and Metastasis through Activation of NOTCH–DAB1–ABL–RHOGEF Protein TRIO
Authors: Sonoshita Masahiro , Itatani Yoshiro , Kakizaki Fumihiko , Sakimura Kenji , Terashima Toshio , Katsuyama Yu , Sakai Yoshiharu , Taketo M. Mark
Published: April 2023

Supplementary Fig. S1 shows Dab1 expression in mouse intestinal tumors and in human CRC cell lines.
Supplementary Figure 2 from Parallel RNA Interference Screens Identify EGFR Activation as an Escape Mechanism in FGFR3-Mutant Cancer
Authors: Herrera-Abreu Maria Teresa , Pearson Alex , Campbell James , Shnyder Steve D. , Knowles Margaret A. , Ashworth Alan , Turner Nicholas C.
Published: April 2023

Supplementary Figure 2 - PDF file 649K, Efficacy of combined targeting of EGFR and FGFR3
Supplementary Figure Legends from Promotion of Colorectal Cancer Invasion and Metastasis through Activation of NOTCH–DAB1–ABL–RHOGEF Protein TRIO
Authors: Sonoshita Masahiro , Itatani Yoshiro , Kakizaki Fumihiko , Sakimura Kenji , Terashima Toshio , Katsuyama Yu , Sakai Yoshiharu , Taketo M. Mark
Published: April 2023

Supplementary Figure Legends S1-S5
Supplementary Figures 1 - 16, Tables 1 - 3 from A Gnotobiotic Mouse Model Demonstrates That Dietary Fiber Protects against Colorectal Tumorigenesis in a Microbiota- and Butyrate-Dependent Manner
Authors: Donohoe Dallas R. , Holley Darcy , Collins Leonard B. , Montgomery Stephanie A. , Whitmore Alan C. , Hillhouse Andrew , Curry Kaitlin P. , Renner Sarah W. , Greenwalt Alicia , Ryan Elizabeth P. , Godfrey Virginia , Heise Mark T. , Threadgill Deborah S. , Han Anna , Swenberg James A. , Threadgill David W. , Bultman Scott J.
Published: April 2023

Supplementary Figure 1. Overall experimental design including the rationale behind specific details. Supplementary Figure 2. Confirmation of the ASF strains and B. fibrisolvens by PCR. Supplementary Figure 3. Formulations of the 3 diets provided to gnotobiotic mice in these experiments. Supplementary Figure 4. A combination of a high-fiber diet and a butyrate-producing bacterium (Butyrivibrio fibrisolvens) yields higher levels of butyrate in the lumen of the colon than either factor in isolation. Supplementary Figure 5. Detection of b-catenin mutations in tumor cells. Supplementary Figure 6. Analysis of b catenin nuclear localization in control and experimental tumors. Supplementary Figure 7. Characterization of squamous cell tumors. Supplementary Figure 8. Analysis of wild-type and mutant B. fibrisolvens strains. Supplementary Figure 9. Expression of Warburg effect markers. Supplementary Figure 10. Butyrate oxidation and uptake in colorectal tumors and normal colonic tissues. Supplementary Figure 11. Representative IHC images showing cleaved caspase 3 positive cells (arrows) in normal colonic tissue and tumors from mice in control and experimental conditions. Supplementary Figure 12. Flow cytometric analysis of immune cell populations from BALB/c mice colonized with the 4 ASF and B. fibrisolvens in gnotobiotic isolators. Supplementary Figure 13. Serum and colonic cytokine levels (pg/mL) from BALB/c mice colonized with the 4 ASF and B. fibrisolvens in gnotobiotic isolators based on Luminex assays. Supplementary Figure 14. Minimal inflammation based on histologic assessment of H&E-stained sections of colorectal tumor sections from 7-10 mice of each treatment group 5 months after exposure to the 5 AOM/3 DSS regimen. Supplementary Figure 15. Control experiment demonstrating that inflammation plays a minor role in colorectal tumorigenesis in the gnotobiotic model where BALB/c mice were polyassociated with 4 ASF plus B. fibrisolvens and then treated with AOM/DSS. Supplementary Figure 16. Relative Il18 mRNA levels normalized to Gapdh levels in normal colonic tissue and tumors based on RT-qPCR experiments. Supplementary Table 1. Luminal Concentrations (μM) of Other Two Major SCFAs (Propionate and Acetate). Supplementary Table 2. Clinical Information Regarding Human Adenocarcinomas. Supplementary Table 3. Statistical tests used for each figure panel.
Supplementary Figures 1 -18 from Aberrant Glycosylation Promotes Lung Cancer Metastasis through Adhesion to Galectins in the Metastatic Niche
Authors: Reticker-Flynn Nathan E. , Bhatia Sangeeta N.
Published: April 2023

Supplementary Fig. 1. Galectin-3 is present within tumors. Supplementary Fig. 2. Analysis of peripheral blood from tumor-bearing mice by flow cytometry. Supplementary Fig. 3. Galectin-3 expression on CD11b+ cells is not dependent on the presence of tumors. Supplementary Fig. 4. Galectin-3 presentation on CD11b+ leukocytes is not carbohydrate dependent. Supplementary Fig. 5. Tumor conditioned medium induces galectin-3-independent mobilization of CD11b+galectin-3+ leukocytes. Supplementary Fig. 6. Galectin-3 is not necessary for mobilization of galectin-3+CD11b+ leukocytes or metastatic seeding. Supplementary Fig. 7. IL-6 induces mobilization of galectin-3+CD11b+ leukocytes. Supplementary Fig. 8. IL-6 induces the mobilization of galectin-3+CD11b+ granulocytes. Supplementary Fig. 9. Galectin-3 expression by leukocytes or stromal cells is not necessary for IL-6-dependent mobilization of myeloid cells. Supplementary Fig. 10. The Thomsen-Friedenreich Antigen is elevated in metastatic cells and human lung cancer tissue. Supplementary Fig. 11. Gene expression microarray analysis of glycosyltransferases shows no evidence of differential regulation of transferases that generate galectin-3 ligands. Supplementary Fig. 12. Differential regulation of select glycosyltransferase activity prevents glycan elongation and preserves T-Antigen presentation. Supplementary Fig. 13. O-linked core 1 disaccharide synthesis is unaltered during metastatic progression, but branching and elongation affect T-Antigen surface presentation. Supplementary Fig. 14. Transfection of Gcnt3 and knockdown of St6galnac4. (A) qRT-PCR for Gcnt3 in 393M1 cells following transfection with Gcnt3. Supplementary Fig. 15. Transfection of Gcnt3 reduces T-Antigen expression and adhesion to galectin-3. Supplementary Fig. 16. Knockdown of St6GalNAcIV reduces the formation of metastases in vivo. Supplementary Fig. 17. Knockdown of St6galnac4 does not affect proliferation. Supplementary Fig. 18. Galectin-3 is elevated in mice bearing tumors.
Supplementary Figure 7 from Obligate Progression Precedes Lung Adenocarcinoma Dissemination
Authors: Caswell Deborah R. , Chuang Chen-Hua , Yang Dian , Chiou Shin-Heng , Cheemalavagu Shashank , Kim-Kiselak Caroline , Connolly Andrew , Winslow Monte M.
Published: April 2023

PDF file 1080K, Molecular characterization of disseminated cancer cells is required to understand the stage of metastatic progression at which Nkx2-1 and genes associated with the Nkx2-1neg state function
Supplementary Figure 6 from Discovery of a Mutant-Selective Covalent Inhibitor of EGFR that Overcomes T790M-Mediated Resistance in NSCLC
Authors: Walter Annette O. , Sjin Robert Tjin Tham , Haringsma Henry J. , Ohashi Kadoaki , Sun Jing , Lee Kwangho , Dubrovskiy Aleksandr , Labenski Matthew , Zhu Zhendong , Wang Zhigang , Sheets Michael , St Martin Thia , Karp Russell , van Kalken Dan , Chaturvedi Prasoon , Niu Deqiang , Nacht Mariana , Petter Russell C. , Westlin William , Lin Kevin , Jaw-Tsai Sarah , Raponi Mitch , Van Dyke Terry , Etter Jeff , Weaver Zoe , Pao William , Singh Juswinder , Simmons Andrew D. , Harding Thomas C. , Allen Andrew
Published: April 2023

Supplementary Figure 6 - PDF file 112K, Impact of CO-1686, erlotinib and afatinib administration on mouse body-weight
Figure S1 from A High-Throughput Fluorimetric Assay for 2-Hydroxyglutarate Identifies Zaprinast as a Glutaminase Inhibitor
Authors: Elhammali Adnan , Ippolito Joseph E. , Collins Lynne , Crowley Jan , Marasa Jayne , Piwnica-Worms David
Published: April 2023

PDF file 23K, 2HG titration curve using coupled fluorimetric assay. A 20 ?L aliquot of 2HG pulsed into media was quantified by fluorescence following acid-base neutralization. Assay signal saturates at 2HG concentrations of 1 mM. Fluorescence is plotted as Arbitrary Units (A.U.)
Supplementary Tables 1 and 2 from Mutant N-RAS Protects Colorectal Cancer Cells from Stress-Induced Apoptosis and Contributes to Cancer Development and Progression
Authors: Wang Yufang , Velho Sérgia , Vakiani Efsevia , Peng Shouyong , Bass Adam J. , Chu Gerald C. , Gierut Jessica , Bugni James M. , Der Channing J. , Philips Mark , Solit David B. , Haigis Kevin M.
Published: April 2023

Supplementary Tables 1 and 2 PDF file 91K, Table 1 contains clinical and genotypic data from the patient cohort referred to in Fig. 6. Table 2 contains shRNA target sequences
Supplementary Table 3 from Cell-Free DNA Next-Generation Sequencing in Pancreatobiliary Carcinomas
Authors: Zill Oliver A. , Greene Claire , Sebisanovic Dragan , Siew Lai Mun , Leng Jim , Vu Mary , Hendifar Andrew E. , Wang Zhen , Atreya Chloe E. , Kelley Robin K. , Van Loon Katherine , Ko Andrew H. , Tempero Margaret A. , Bivona Trever G. , Munster Pamela N. , Talasaz AmirAli , Collisson Eric A.
Published: April 2023

Tumor marker levels and cfDNA mutant allele fractions across 19 time intervals for eight patients that were serially monitored via blood draws.
Supplementary Figure S5 from Mutant N-RAS Protects Colorectal Cancer Cells from Stress-Induced Apoptosis and Contributes to Cancer Development and Progression
Authors: Wang Yufang , Velho Sérgia , Vakiani Efsevia , Peng Shouyong , Bass Adam J. , Chu Gerald C. , Gierut Jessica , Bugni James M. , Der Channing J. , Philips Mark , Solit David B. , Haigis Kevin M.
Published: April 2023

Supplementary Figure S5 PDF file 101K, Confirmation of RAF knockdown cells
Supplementary Figure S2 from Mutant N-RAS Protects Colorectal Cancer Cells from Stress-Induced Apoptosis and Contributes to Cancer Development and Progression
Authors: Wang Yufang , Velho Sérgia , Vakiani Efsevia , Peng Shouyong , Bass Adam J. , Chu Gerald C. , Gierut Jessica , Bugni James M. , Der Channing J. , Philips Mark , Solit David B. , Haigis Kevin M.
Published: April 2023

Supplementary Figure S2 PDF file 112K,Data related to the establishment and confirmation of CRC cell lines expressing different mutant forms of Ras
Supplementary Table 1 from Mcl-1 and FBW7 Control a Dominant Survival Pathway Underlying HDAC and Bcl-2 Inhibitor Synergy in Squamous Cell Carcinoma
Authors: He Lei , Torres-Lockhart Kristine , Forster Nicole , Ramakrishnan Saranya , Greninger Patricia , Garnett Mathew J. , McDermott Ultan , Rothenberg Stephen M. , Benes Cyril H. , Ellisen Leif W.
Published: April 2023

Supplementary Table 1 PDF file 19K, QRT-PCR primer and Taqman probe sequences
Supplementary Video 1 from Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance
Authors: Karsli-Uzunbas Gizem , Guo Jessie Yanxiang , Price Sandy , Teng Xin , Laddha Saurabh V , Khor Sinan , Kalaany Nada Y. , Jacks Tyler , Chan Chang S. , Rabinowitz Joshua D. , White Eileen
Published: April 2023

MOV file - 7511KB, Acute autophagy ablation causes progressive motor and behavioral deficits.
Supplementary Table 4 from Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance
Authors: Karsli-Uzunbas Gizem , Guo Jessie Yanxiang , Price Sandy , Teng Xin , Laddha Saurabh V , Khor Sinan , Kalaany Nada Y. , Jacks Tyler , Chan Chang S. , Rabinowitz Joshua D. , White Eileen
Published: April 2023

PDF file - 2587KB, Comparison of collapsed expression of all muscle genes during fasting.
Supplementary Table 3 from Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance
Authors: Karsli-Uzunbas Gizem , Guo Jessie Yanxiang , Price Sandy , Teng Xin , Laddha Saurabh V , Khor Sinan , Kalaany Nada Y. , Jacks Tyler , Chan Chang S. , Rabinowitz Joshua D. , White Eileen
Published: April 2023

PDF file - 2193KB, Comparison of collapsed expression of all liver genes during fasting.
Supplementary Table S3 from Comprehensive Genomic Profiling of Pancreatic Acinar Cell Carcinomas Identifies Recurrent RAF Fusions and Frequent Inactivation of DNA Repair Genes
Authors: Chmielecki Juliann , Hutchinson Katherine E. , Frampton Garrett M. , Chalmers Zachary R. , Johnson Adrienne , Shi Chanjuan , Elvin Julia , Ali Siraj M. , Ross Jeffrey S. , Basturk Olca , Balasubramanian Sohail , Lipson Doron , Yelensky Roman , Pao William , Miller Vincent A. , Klimstra David S. , Stephens Philip J.
Published: April 2023

Supplementary Table S3: Genomic alterations across selected targets. See Figure 3 for additional details. Zoomable PDF.
Supplementary Table S2A - S2C from Comprehensive Genomic Profiling of Pancreatic Acinar Cell Carcinomas Identifies Recurrent RAF Fusions and Frequent Inactivation of DNA Repair Genes
Authors: Chmielecki Juliann , Hutchinson Katherine E. , Frampton Garrett M. , Chalmers Zachary R. , Johnson Adrienne , Shi Chanjuan , Elvin Julia , Ali Siraj M. , Ross Jeffrey S. , Basturk Olca , Balasubramanian Sohail , Lipson Doron , Yelensky Roman , Pao William , Miller Vincent A. , Klimstra David S. , Stephens Philip J.
Published: April 2023

Supplementary Table S2A: Genes analyzed for base substitutions, short insertions/deletions, and copy number alterations (DNA). Supplementary Table S2B: Genes analyzed for rearrangements (DNA). Supplementary Table S2C: Genes analyzed for rearrangements (RNA). Zoomable PDF.
Supplementary Methods from Comprehensive Genomic Profiling of Pancreatic Acinar Cell Carcinomas Identifies Recurrent RAF Fusions and Frequent Inactivation of DNA Repair Genes
Authors: Chmielecki Juliann , Hutchinson Katherine E. , Frampton Garrett M. , Chalmers Zachary R. , Johnson Adrienne , Shi Chanjuan , Elvin Julia , Ali Siraj M. , Ross Jeffrey S. , Basturk Olca , Balasubramanian Sohail , Lipson Doron , Yelensky Roman , Pao William , Miller Vincent A. , Klimstra David S. , Stephens Philip J.
Published: April 2023

Additional detailed methods.
Supplementary Data Tables from Molecular Profiling of the Residual Disease of Triple-Negative Breast Cancers after Neoadjuvant Chemotherapy Identifies Actionable Therapeutic Targets
Authors: Balko Justin M. , Giltnane Jennifer M. , Wang Kai , Schwarz Luis J. , Young Christian D. , Cook Rebecca S. , Owens Phillip , Sanders Melinda E. , Kuba Maria G. , Sánchez Violeta , Kurupi Richard , Moore Preston D. , Pinto Joseph A. , Doimi Franco D. , Gómez Henry , Horiuchi Dai , Goga Andrei , Lehmann Brian D. , Bauer Joshua A. , Pietenpol Jennifer A. , Ross Jeffrey S. , Palmer Gary A. , Yelensky Roman , Cronin Maureen , Miller Vincent A. , Stephens Phillip J. , Arteaga Carlos L.
Published: April 2023

XLSX file 706K, This file contains 8 supplementary data tables which include patient demographics, genes and alterations assessed by NGS, Nanostring gene expression data, and bioinformatics analyses
Supplementary Data Figure Legends from Molecular Profiling of the Residual Disease of Triple-Negative Breast Cancers after Neoadjuvant Chemotherapy Identifies Actionable Therapeutic Targets
Authors: Balko Justin M. , Giltnane Jennifer M. , Wang Kai , Schwarz Luis J. , Young Christian D. , Cook Rebecca S. , Owens Phillip , Sanders Melinda E. , Kuba Maria G. , Sánchez Violeta , Kurupi Richard , Moore Preston D. , Pinto Joseph A. , Doimi Franco D. , Gómez Henry , Horiuchi Dai , Goga Andrei , Lehmann Brian D. , Bauer Joshua A. , Pietenpol Jennifer A. , Ross Jeffrey S. , Palmer Gary A. , Yelensky Roman , Cronin Maureen , Miller Vincent A. , Stephens Phillip J. , Arteaga Carlos L.
Published: April 2023

PDF file 64K, Legends for all supplementary data figures (1-7)
Supplementary Figure S1 from Comprehensive Genomic Profiling of Pancreatic Acinar Cell Carcinomas Identifies Recurrent RAF Fusions and Frequent Inactivation of DNA Repair Genes
Authors: Chmielecki Juliann , Hutchinson Katherine E. , Frampton Garrett M. , Chalmers Zachary R. , Johnson Adrienne , Shi Chanjuan , Elvin Julia , Ali Siraj M. , Ross Jeffrey S. , Basturk Olca , Balasubramanian Sohail , Lipson Doron , Yelensky Roman , Pao William , Miller Vincent A. , Klimstra David S. , Stephens Philip J.
Published: April 2023

Supplementary Fig. S1: GTL16 gastric adenocarcinoma cells derived to be resistant to MET inhibition and containing a similar SND1-BRAF fusion are sensitive to trametinib.
Supplementary Data Figure 5 from Molecular Profiling of the Residual Disease of Triple-Negative Breast Cancers after Neoadjuvant Chemotherapy Identifies Actionable Therapeutic Targets
Authors: Balko Justin M. , Giltnane Jennifer M. , Wang Kai , Schwarz Luis J. , Young Christian D. , Cook Rebecca S. , Owens Phillip , Sanders Melinda E. , Kuba Maria G. , Sánchez Violeta , Kurupi Richard , Moore Preston D. , Pinto Joseph A. , Doimi Franco D. , Gómez Henry , Horiuchi Dai , Goga Andrei , Lehmann Brian D. , Bauer Joshua A. , Pietenpol Jennifer A. , Ross Jeffrey S. , Palmer Gary A. , Yelensky Roman , Cronin Maureen , Miller Vincent A. , Stephens Phillip J. , Arteaga Carlos L.
Published: April 2023

PDF file 62K, MCL1 overexpression enhances docetaxel resistance in non-amplified TNBC cell lines
Supplementary Data from Autophagy-Dependent Production of Secreted Factors Facilitates Oncogenic RAS-Driven Invasion
Authors: Lock Rebecca , Kenific Candia M. , Leidal Andrew M. , Salas Eduardo , Debnath Jayanta
Published: April 2023

PDF file 112K, Document containing Supplemental Methods and Supplemental Figure Legends
Supplementary Data Figure 4 from Molecular Profiling of the Residual Disease of Triple-Negative Breast Cancers after Neoadjuvant Chemotherapy Identifies Actionable Therapeutic Targets
Authors: Balko Justin M. , Giltnane Jennifer M. , Wang Kai , Schwarz Luis J. , Young Christian D. , Cook Rebecca S. , Owens Phillip , Sanders Melinda E. , Kuba Maria G. , Sánchez Violeta , Kurupi Richard , Moore Preston D. , Pinto Joseph A. , Doimi Franco D. , Gómez Henry , Horiuchi Dai , Goga Andrei , Lehmann Brian D. , Bauer Joshua A. , Pietenpol Jennifer A. , Ross Jeffrey S. , Palmer Gary A. , Yelensky Roman , Cronin Maureen , Miller Vincent A. , Stephens Phillip J. , Arteaga Carlos L.
Published: April 2023

PDF file 152K, Gains, enrichments, reductions and losses of gene alterations post-NAC in TNBCs
Figure S3 from Autophagy-Dependent Production of Secreted Factors Facilitates Oncogenic RAS-Driven Invasion
Authors: Lock Rebecca , Kenific Candia M. , Leidal Andrew M. , Salas Eduardo , Debnath Jayanta
Published: April 2023

PDF file 2610K, Effects of conditioned media treatment and recombinant human IL6 re-addition on BABE and HRASV12 shATG 3D cultures
Figure S1 from Autophagy-Dependent Production of Secreted Factors Facilitates Oncogenic RAS-Driven Invasion
Authors: Lock Rebecca , Kenific Candia M. , Leidal Andrew M. , Salas Eduardo , Debnath Jayanta
Published: April 2023

PDF file 1868K, ATG knockdown inhibits Ras-driven invasion in 3D culture
Supplementary Table 3 from Combined Inhibition of MAP Kinase and KIT Signaling Synergistically Destabilizes ETV1 and Suppresses GIST Tumor Growth
Authors: Ran Leili , Sirota Inna , Cao Zhen , Murphy Devan , Chen Yuedan , Shukla Shipra , Xie Yuanyuan , Kaufmann Michael C. , Gao Dong , Zhu Sinan , Rossi Ferdinando , Wongvipat John , Taguchi Takahiro , Tap William D. , Mellinghoff Ingo K. , Besmer Peter , Antonescu Cristina R. , Chen Yu , Chi Ping
Published: April 2023

Supplementary Table 3: Gene sets enriched among genes UPregulated by tamoxifen treatment (Etv1 ablation) in murine GIST-like tumors.
Supplementary Figure Legends from Combined Inhibition of MAP Kinase and KIT Signaling Synergistically Destabilizes ETV1 and Suppresses GIST Tumor Growth
Authors: Ran Leili , Sirota Inna , Cao Zhen , Murphy Devan , Chen Yuedan , Shukla Shipra , Xie Yuanyuan , Kaufmann Michael C. , Gao Dong , Zhu Sinan , Rossi Ferdinando , Wongvipat John , Taguchi Takahiro , Tap William D. , Mellinghoff Ingo K. , Besmer Peter , Antonescu Cristina R. , Chen Yu , Chi Ping
Published: April 2023

Supplementary Figure Legends
Supplemental Methods from Development of siRNA Payloads to Target KRAS-Mutant Cancer
Authors: Yuan Tina L. , Fellmann Christof , Lee Chih-Shia , Ritchie Cayde D. , Thapar Vishal , Lee Liam C. , Hsu Dennis J. , Grace Danielle , Carver Joseph O. , Zuber Johannes , Luo Ji , McCormick Frank , Lowe Scott W.
Published: April 2023

Supplemental Methods from Development of siRNA Payloads to Target KRAS-Mutant Cancer
Data Supplement from Active CREB1 Promotes a Malignant TGFβ2 Autocrine Loop in Glioblastoma
Authors: Rodón Laura , Gonzàlez-Juncà Alba , del Mar Inda María , Sala-Hojman Ada , Martínez-Sáez Elena , Seoane Joan
Published: April 2023

This file contains the supplementary figure legends related to the correlation of p-SMAD2 and p-CREB in GBM patients and the quantification of tumor growth in GBM PDX models expressing shCREB1.
Supplementary Table and Figure Legends from Canonical Wnt/β-catenin Signaling Drives Human Schwann Cell Transformation, Progression, and Tumor Maintenance
Authors: Watson Adrienne L. , Rahrmann Eric P. , Moriarity Branden S. , Choi Kwangmin , Conboy Caitlin B. , Greeley Andrew D. , Halfond Amanda L. , Anderson Leah K. , Wahl Brian R. , Keng Vincent W. , Rizzardi Anthony E. , Forster Colleen L. , Collins Margaret H. , Sarver Aaron L. , Wallace Margaret R. , Schmechel Stephen C. , Ratner Nancy , Largaespada David A.
Published: April 2023

Supplementary Table and Figure Legends-PDF file 123K, Supplementary Table and Figure Legends
Supplementary Table 1 from Canonical Wnt/β-catenin Signaling Drives Human Schwann Cell Transformation, Progression, and Tumor Maintenance
Authors: Watson Adrienne L. , Rahrmann Eric P. , Moriarity Branden S. , Choi Kwangmin , Conboy Caitlin B. , Greeley Andrew D. , Halfond Amanda L. , Anderson Leah K. , Wahl Brian R. , Keng Vincent W. , Rizzardi Anthony E. , Forster Colleen L. , Collins Margaret H. , Sarver Aaron L. , Wallace Margaret R. , Schmechel Stephen C. , Ratner Nancy , Largaespada David A.
Published: April 2023

Supplementary Table 1 - PDF 95K, Genes listed were identified in a murine SB screen for drivers of Schwann cell tumorigenesis, and all have known roles in canonical Wnt/β-catenin signaling. Listed are the percentage of neurofibromas or MPNSTs with an SB insertion within or near the gene listed, as well as the total number of tumors within a given gene.
Supplementary Figure 4 from Canonical Wnt/β-catenin Signaling Drives Human Schwann Cell Transformation, Progression, and Tumor Maintenance
Authors: Watson Adrienne L. , Rahrmann Eric P. , Moriarity Branden S. , Choi Kwangmin , Conboy Caitlin B. , Greeley Andrew D. , Halfond Amanda L. , Anderson Leah K. , Wahl Brian R. , Keng Vincent W. , Rizzardi Anthony E. , Forster Colleen L. , Collins Margaret H. , Sarver Aaron L. , Wallace Margaret R. , Schmechel Stephen C. , Ratner Nancy , Largaespada David A.
Published: April 2023

Supplementary Figure 4 - PDF file 111K, Reduction of Wnt signaling by β-catenin knockdown or GSK3B overexpression reduces tumor growth in xenograft models
Supplementary Figure S1 from Lysine Demethylase KDM4A Associates with Translation Machinery and Regulates Protein Synthesis
Authors: Van Rechem Capucine , Black Joshua C. , Boukhali Myriam , Aryee Martin J. , Gräslund Susanne , Haas Wilhelm , Benes Cyril H. , Whetstine Johnathan R.
Published: April 2023

Supplementary Figure S1. KDM4A depletion and catalytic mutant alter the distribution of translation initiation factors.
Supplementary Figures 1 - 11, Tables 1 - 3 from Ligand-Independent EPHA2 Signaling Drives the Adoption of a Targeted Therapy–Mediated Metastatic Melanoma Phenotype
Authors: Paraiso Kim H.T. , Thakur Meghna Das , Fang Bin , Koomen John M. , Fedorenko Inna V. , John Jobin K. , Tsao Hensin , Flaherty Keith T. , Sondak Vernon K. , Messina Jane L. , Pasquale Elena B. , Villagra Alejandro , Rao Uma N. , Kirkwood John M. , Meier Friedegund , Sloot Sarah , Gibney Geoffrey T. , Stuart Darrin , Tawbi Hussein , Smalley Keiran S.M.
Published: April 2023

Supplemental Figure 1. Characterization of the resistant cell lines. Supplemental Figure 2. Quantification of the cell invasion from figure 1D. Supplemental Figure 3. Model showing ligand dependent and independent ephrin signaling. Supplemental Figure 4. Acute drug treatment does not induce ligand independent ephrin signaling. Supplemental Figure 5. Quantification of matrigel invasion data from Figure 2E. Supplemental Figure 6. knockdown of EphA2 does not resensitize to BRAF inhibition. Supplemental Figure 7. PI3K and AKT inhibitors block AKT signaling. Supplemental Figure 8. Removal of drug increases cell doubling time. Supplemental Figure 9. Removal of drug reverses the resistance phenotype. Supplemental Figure 10. Removal of drug reverses EphA2 signaling and melanoma invasion. Supplemental Figure 11. Time course of EphA2 induction following chronic BRAF inhibition Supplemental Table 1. Levels of EphA2 staining in primary and metastatic melanoma lesions Supplemental Table 2. Increased EphA2 staining observed in melanoma patient specimens on BRAF inhibitor trial Supplemental Table 3. Incidence of new metastases in patients treated with either vemurafenib or dacarbazine.
Supplementary Methods and Figure Legends from Targeted Inhibition of the Molecular Chaperone Hsp90 Overcomes ALK Inhibitor Resistance in Non–Small Cell Lung Cancer
Authors: Sang Jim , Acquaviva Jaime , Friedland Julie C. , Smith Donald L. , Sequeira Manuel , Zhang Chaohua , Jiang Qin , Xue Liquan , Lovly Christine M. , Jimenez John-Paul , Shaw Alice T. , Doebele Robert C. , He Suqin , Bates Richard C. , Camidge D. Ross , Morris Stephan W. , El-Hariry Iman , Proia David A.
Published: April 2023

PDF file - 71K
Supplementary Figure 4 from Targeted Inhibition of the Molecular Chaperone Hsp90 Overcomes ALK Inhibitor Resistance in Non–Small Cell Lung Cancer
Authors: Sang Jim , Acquaviva Jaime , Friedland Julie C. , Smith Donald L. , Sequeira Manuel , Zhang Chaohua , Jiang Qin , Xue Liquan , Lovly Christine M. , Jimenez John-Paul , Shaw Alice T. , Doebele Robert C. , He Suqin , Bates Richard C. , Camidge D. Ross , Morris Stephan W. , El-Hariry Iman , Proia David A.
Published: April 2023

PDF file - 2538K, Crizotinib-resistant H3122 CR1 cells express an EMT phenotype.
Supplementary Figure 3 from Targeted Inhibition of the Molecular Chaperone Hsp90 Overcomes ALK Inhibitor Resistance in Non–Small Cell Lung Cancer
Authors: Sang Jim , Acquaviva Jaime , Friedland Julie C. , Smith Donald L. , Sequeira Manuel , Zhang Chaohua , Jiang Qin , Xue Liquan , Lovly Christine M. , Jimenez John-Paul , Shaw Alice T. , Doebele Robert C. , He Suqin , Bates Richard C. , Camidge D. Ross , Morris Stephan W. , El-Hariry Iman , Proia David A.
Published: April 2023

PDF file - 486K, The addition of ganetespib to crizotinib does not result in added toxicity in H3122 xenografts.
Supplementary Figure 2 from Targeted Inhibition of the Molecular Chaperone Hsp90 Overcomes ALK Inhibitor Resistance in Non–Small Cell Lung Cancer
Authors: Sang Jim , Acquaviva Jaime , Friedland Julie C. , Smith Donald L. , Sequeira Manuel , Zhang Chaohua , Jiang Qin , Xue Liquan , Lovly Christine M. , Jimenez John-Paul , Shaw Alice T. , Doebele Robert C. , He Suqin , Bates Richard C. , Camidge D. Ross , Morris Stephan W. , El-Hariry Iman , Proia David A.
Published: April 2023

PDF file - 727K, Ganetespib and crizotinib are similarly efficacious in H3122 xenograft tumors implanted in nude mice.
Supplementary Table 2 from Selective BCL-2 Inhibition by ABT-199 Causes On-Target Cell Death in Acute Myeloid Leukemia
Authors: Pan Rongqing , Hogdal Leah J. , Benito Juliana M. , Bucci Donna , Han Lina , Borthakur Gautam , Cortes Jorge , DeAngelo Daniel J. , Debose LaKeisha , Mu Hong , Döhner Hartmut , Gaidzik Verena I. , Galinsky Ilene , Golfman Leonard S. , Haferlach Torsten , Harutyunyan Karine G. , Hu Jianhua , Leverson Joel D. , Marcucci Guido , Müschen Markus , Newman Rachel , Park Eugene , Ruvolo Peter P. , Ruvolo Vivian , Ryan Jeremy , Schindela Sonja , Zweidler-McKay Patrick , Stone Richard M. , Kantarjian Hagop , Andreeff Michael , Konopleva Marina , Letai Anthony G.
Published: April 2023

PDF file 118K, This table includes genetic information of the AML patients studied in this manucript
Supplementary Figures from SPSB1 Promotes Breast Cancer Recurrence by Potentiating c-MET Signaling
Authors: Feng Yi , Pan Tien-Chi , Pant Dhruv K. , Chakrabarti Kristi R. , Alvarez James V. , Ruth Jason R. , Chodosh Lewis A.
Published: April 2023

PDF file 645K, This file contains supplemental figures that provided supportive evidence to the main conclusion described in the manuscript
Supplementary Figures from Selective BCL-2 Inhibition by ABT-199 Causes On-Target Cell Death in Acute Myeloid Leukemia
Authors: Pan Rongqing , Hogdal Leah J. , Benito Juliana M. , Bucci Donna , Han Lina , Borthakur Gautam , Cortes Jorge , DeAngelo Daniel J. , Debose LaKeisha , Mu Hong , Döhner Hartmut , Gaidzik Verena I. , Galinsky Ilene , Golfman Leonard S. , Haferlach Torsten , Harutyunyan Karine G. , Hu Jianhua , Leverson Joel D. , Marcucci Guido , Müschen Markus , Newman Rachel , Park Eugene , Ruvolo Peter P. , Ruvolo Vivian , Ryan Jeremy , Schindela Sonja , Zweidler-McKay Patrick , Stone Richard M. , Kantarjian Hagop , Andreeff Michael , Konopleva Marina , Letai Anthony G.
Published: April 2023

PDF file 433K, This includes supplemental figures referenced in the article text
Supplemental Table 1 from ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents
Authors: Agnihotri Sameer , Burrell Kelly , Buczkowicz Pawel , Remke Marc , Golbourn Brian , Chornenkyy Yevgen , Gajadhar Aaron , Fernandez Nestor A. , Clarke Ian D. , Barszczyk Mark S. , Pajovic Sanja , Ternamian Christian , Head Renee , Sabha Nesrin , Sobol Robert W. , Taylor Michael D. , Rutka James T. , Jones Chris , Dirks Peter B. , Zadeh Gelareh , Hawkins Cynthia
Published: April 2023

PDF file - 96KB, Supplemental Table 1: Predicted phosphorylation sites for human MPG.
Supplemental Figures 1 - 9 from ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents
Authors: Agnihotri Sameer , Burrell Kelly , Buczkowicz Pawel , Remke Marc , Golbourn Brian , Chornenkyy Yevgen , Gajadhar Aaron , Fernandez Nestor A. , Clarke Ian D. , Barszczyk Mark S. , Pajovic Sanja , Ternamian Christian , Head Renee , Sabha Nesrin , Sobol Robert W. , Taylor Michael D. , Rutka James T. , Jones Chris , Dirks Peter B. , Zadeh Gelareh , Hawkins Cynthia
Published: April 2023

PDF file - 432KB, Supplementary Figure 1: Validation of Temozolomide (TMZ) siRNA Screen. Supplementary Figure 2: Base Excision Repair correlates with IC50 of alkylating agents. Supplementary Figure 3: Loss of MPG promotes sensitivity to alkylating agents. Supplementary Figure 4: Over-expression of MPG promotes resistance to TMZ. Supplementary Figure 5: Targeting multiple DNA repair proteins has an additive effect on TMZ sensitivity. Supplementary Figure 6: ATM interacts with MPG and regulates MPG glycosylase activity. Supplementary Figure 7: Methoxyamine enhances cytotoxicity of TMZ in pGBM cell lines. Supplementary Figure 8: Methoxyamine enhances cytotoxicity of TMZ in primary pGBM cultures. Supplementary Figure 9: Normal astrocytes have redundant pathways limiting cytotoxicity when the ATM-MPG pathways are inhibited.
Supplemental Figure Legends from ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents
Authors: Agnihotri Sameer , Burrell Kelly , Buczkowicz Pawel , Remke Marc , Golbourn Brian , Chornenkyy Yevgen , Gajadhar Aaron , Fernandez Nestor A. , Clarke Ian D. , Barszczyk Mark S. , Pajovic Sanja , Ternamian Christian , Head Renee , Sabha Nesrin , Sobol Robert W. , Taylor Michael D. , Rutka James T. , Jones Chris , Dirks Peter B. , Zadeh Gelareh , Hawkins Cynthia
Published: April 2023

PDF file - 95KB
Supplementary Material from mTOR Inhibition Specifically Sensitizes Colorectal Cancers with KRAS or BRAF Mutations to BCL-2/BCL-XL Inhibition by Suppressing MCL-1
Authors: Faber Anthony C. , Coffee Erin M. , Costa Carlotta , Dastur Anahita , Ebi Hiromichi , Hata Aaron N. , Yeo Alan T. , Edelman Elena J. , Song Youngchul , Tam Ah Ting , Boisvert Jessica L. , Milano Randy J. , Roper Jatin , Kodack David P. , Jain Rakesh K. , Corcoran Ryan B. , Rivera Miguel N. , Ramaswamy Sridhar , Hung Kenneth E. , Benes Cyril H. , Engelman Jeffrey A.
Published: April 2023

PDF file140K, Supplementary figure legends
Supplementary Figure 2 from p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
Authors: Alspach Elise , Flanagan Kevin C. , Luo Xianmin , Ruhland Megan K. , Huang Hui , Pazolli Ermira , Donlin Maureen J. , Marsh Timothy , Piwnica-Worms David , Monahan Joseph , Novack Deborah V. , McAllister Sandra S. , Stewart Sheila A.
Published: April 2023

PDF file 545K, SASP upregulation following bleomycin, NaB or replication-induced senescence. SASP mRNA stabilization in NaB-treated BJs and in bleomycin-treated IMR90s
Supplementary Figure 5 from Autophagy Inhibition Improves Chemosensitivity in BRAFV600E Brain Tumors
Authors: Levy Jean M. Mulcahy , Thompson Joshua C. , Griesinger Andrea M. , Amani Vladimir , Donson Andrew M. , Birks Diane K. , Morgan Michael J. , Mirsky David M. , Handler Michael H. , Foreman Nicholas K. , Thorburn Andrew
Published: April 2023

PDF file 31K, Autophagic flux by flow cytometry in vemurafenib treated cells
Supplementary Figure 3 from Autophagy Inhibition Improves Chemosensitivity in BRAFV600E Brain Tumors
Authors: Levy Jean M. Mulcahy , Thompson Joshua C. , Griesinger Andrea M. , Amani Vladimir , Donson Andrew M. , Birks Diane K. , Morgan Michael J. , Mirsky David M. , Handler Michael H. , Foreman Nicholas K. , Thorburn Andrew
Published: April 2023

PDF file 121K, Incucyte growth analysis and western blot analysis