bluuebunny/crossref_metadata_2025 huggingface dataset:
Terracotta Female Musicians from the Sanctuary of Fontana Calda (Sicily)
Authors: Bellia Angela
Published: June 2019

In the Sanctuary of the Fontana Calda in Butera (central-south Sicily) was brought to light a sacred deposit. The discovery, made in the 1950s, revealed, among many other things, hundreds of single statuettes of aulos, tympanon, kymbala, and harp players, and groups of aulos and tympanon players. They can be dated between the end of the 6th c. and the beginning of the 3rd c. BC. Many other places in Sicily have yielded these particular types, especially sanctuaries like Fontana Calda that were dedicated to “chthonic” divinities. The representations seem to refer to ceremonies where the protagonists were exclusively women, with the musical instruments perhaps evoking exact episodes of myth and the sorrowful search by the mother of Kore, who had been abducted by Hades. Music was the background in every moment of the sacred ritual of which the female musicians of Fontana Calda offer a rich and singular repertory.
Terracotta Figurines from the Hellenistic Bath Complex in the Agora of Thessaloniki
Authors: Zografou Elektra
Published: June 2019

In the Hellenistic Balneary, which has been discovered in the southeast corner of Thessaloniki’s Roman Agora, has been identified, among others, a two-storey tavern. Through the study of artefacts and architectural remains emerges the conclusion that at the ground floor the owners of the tavern kept their supplies, prepared and served food and drink to the customers, while it is evident that these activities were accompanied by small-scale theatricals and dancing. The upper storey was divided into small separate rooms, where sexual services were presented. Among the most representative finds that led to the identification of the rooms are the three hundred or so fragments of terracotta figurines. They include a great number of theatrical masks of all theatrical genres, which were primarily meant for active use. Terracotta figurines presenting gladiators, a child riding a cock, puppets, cradles, eagles, statuettes of Aphrodite, Athena, Great Mother Goddess and her consort Attis, young Telesphoros, Sirens, Medusas’ and other apotropaic symbols, operate as a source of information about their cultic preferences, their prejudices and superstitions, and even their toys.
Koinès méditerranéennes à Beyrouth
Authors: Picaud Sophie
Published: June 2019

De 1993 à 1999, ont été fouillés des quartiers d’habitation dans le centre-ville de Beyrouth. Cette note présente les trouvailles de figurines de terre cuite, datées de l’époque perse à l’époque romaine.
La tomba 404 della necropoli nord-orientale di Tebe (Beozia)
Authors: Bonanno Aravantinos Margherita
Published: June 2019

La vaste nécropole nord-est de la Thèbes antique, à environ 2 km du centre de la cité, a été explorée dans les années 1999-2001 : y ont été fouillées 843 tombes de types divers. C’est le mobilier particulièrement riche d’une tombe de jeune fille, la tombe 404 dans le secteur sud, datée du milieu du ive s. av. J.-C., qui est présenté ici. Il comporte 15 statuettes de types féminins, 3 chaussures en terre cuite, 2 cratères à figures rouges, des perles de collier en pâte de verre colorée, 5 objets coniques en terre cuite (fleurs ?). Deux statuettes féminines, l’une trônante, l’autre assise sur un klismos, ainsi que 2 représentations d’acrobates présentent un intérêt particulier.
Trois tombes d’enfants de la nécropole de Parion
Authors: Kozanli Candan
Published: June 2019

Les fouilles préventives dans la nécropole méridionale de Parion ont mis au jour en 2004 trois tombes d’enfants en très bas-âge, datées de l’époque d’Auguste. On y a recueilli respectivement 74, 8 et 2 statuettes de terre cuite, dont l’intérêt réside dans le répertoire, largement dominé par les types juvéniles masculins et les animaux, et les nombreuses signatures et marques.
Drakospilia : une grotte cultuelle aux confins occidentaux de Céphalonie
Authors: Samartzidou-Orkopoulou Stavroula
Published: June 2019

La grotte de Drakospilia, dans la chôra de Paleis (Πάλη), à l’extrémité occidentale de Céphalonie, a livré des quantités d’offrandes en terre cuite datant de la fin de l’époque archaïque à l’époque hellénistique. Parmi elles dominent d’une part des protomés féminines de types divers, d’autre part d’originaux pinakes, plaques décorées de reliefs, représentant des divinités, des protomés féminines de profil, des rondes de Nymphes. Plusieurs indices suggèrent une production locale destinée à un culte de divinités de la nature, au premier rang desquelles les Nymphes et Artémis. Les trouvailles témoignent des contacts de Paleis tant régionaux (îles de la mer ionienne) que plus éloignés, en Grèce et avec l’Italie méridionale surtout.
Implications of Intrachromosomal Amplification of Chromosome 21 on Outcome in Pediatric Acute Lymphoblastic Leukemia: Does It Affect Our Patients Too?
Authors: Al-Sweedan Suleimman , Altahan Rahaf
Published: June 2019

Intrachromosomal amplification (iAMP) of chromosome 21 entity is associated with a dismal outcome in B cell Acute Lymphoblastic Leukemia (B-ALL). This cytogenetic abnormality is caused by a novel mechanism; breakage-fusion-bridge cycles followed by chromothripsis along with major gross rearrangements in chromosome 21.Charts of B-ALL diagnosed at King Faisal Specialist Hospital and Research Center between 2005 and 2015 were reviewed.iAMP is a rare entity occurring at around 2.4% of all pediatrics B-ALL. No statistically significant difference was found among patients with iAMP21, patients with extra copies of 21 and other patients with B-ALL. The reported adverse prognostic effect of iAMP21 could be due to other coexistent adverse factors, including older age at the time of diagnosis. The most common associated abnormality in our population in addition to the hyperdiploidy was ETV6/RUNX1.
Severe complications of tramadol overdose in Iran
Authors: Habibollahi Paria , Garjani Alireza , Shams Vahdati Samad , Sadat-Ebrahimi Seyyed-Reza , Parnianfard Neda
Published: June 2019

OBJECTIVES: Severe complications of tramadol overdose have been reported; however, few large-scale studies have investigated this issue. Therefore, this study aimed to explore the presentation and complications of tramadol overdose in patients admitted to an intoxication referral center in northwestern Iran.METHODS: Patients with tramadol overdose admitted to Sina Teaching Hospital in Tabriz, Iran during 2013-2017 were included. For each patient, the following data were collected: demographics, previous drug or medication overdose, whether the patient was in the process of quitting drug use, ingested dose of tramadol and co-ingestants, Glasgow Coma Scale (GCS) score, clinical symptoms at the time of admission, and admission characteristics. Serotonin toxicity was diagnosed in patients who fit the Hunter criteria. Multiple logistic regression was performed to identify variables associated with the incidence of severe complications of tramadol overdose.RESULTS: In total, 512 cases of tramadol overdose were evaluated, of which 359 patients were included, with a median age of 41 years (range, 16-69) and a median tramadol dose of 1,500 mg (range, 500-4,000). The most frequent complications associated with tramadol overdose were hypertension (38.4%), tachycardia (24.8%), and seizure (14.5%). No serotonin toxicity was detected in patients. Having a GCS score <15, having taken a tramadol dose of >1,000 mg, being in the process of quitting drug use, being 30-49 years old, and male sex were significantly related to the incidence of severe complications of tramadol overdose.CONCLUSIONS: Although seizure was prevalent among Iranian patients with tramadol poisoning, serotonin toxicity and cardiogenic shock were rare findings.
Effects of a cancer prevention education program on elementary school students’ knowledge, attitude, self-efficacy, and intentions in South Korea
Authors: Kye Su Yeon , Hwang Soon-Yong , Oh Kyung Hee , Jun Jae Kwan
Published: June 2019

OBJECTIVES: Most children and adolescents have low levels of cancer knowledge and awareness, and infrequently engage in preventive behaviors. This study examined the effects of a short classroom-based intervention for cancer prevention on knowledge, attitude toward cancer preventability, self-efficacy, and behavioral intentions of fifth-grade elementary school students.METHODS: The study was based on a pre-post-follow-up, 2-group, quasi-experimental design. Participants in the intervention group attended two 40-minute sessions on cancer prevention education and watched a music video about cancer prevention, while participants in the control group were only exposed to the music video. Self-reported knowledge, attitude toward cancer preventability, self-efficacy, and behavioral intentions were assessed 1 week pre-intervention and post-intervention, as well as 3 months post-intervention.RESULTS: The 3-month post-intervention results revealed partial effects, indicating that the education intervention improved knowledge and attitudes toward cancer preventability; however, no effects were observed on self-efficacy and behavioral intentions 3 months after the intervention.CONCLUSIONS: Long-term regular booster sessions are required to improve not only social-cognitive factors, but also behavioral intentions, which could result in behavior changes promoting cancer prevention.
The Factor Influencing Organizational Citizenship Behavior of Employees in Private Universities in South Sumatera Province
Authors: Anggraini Desi Ulpa , Wibowo Wibowo , Riyadi Hanes , Umar Husein
Published: June 2019

The objectives of this study is to analyze the factors affecting Organizational Citizenship Behavior (OCB) Nonacademic Employees in Private Universities in South Sumatra. The research design used in the study is explanatory design which explains the causal relationship among variables and scoring all indicators for each variables. The study location is in South Sumatra Province while the research objects are 13 Private Universities with 200 nonacademic employees as respondents. This dissertation used primary data from questionnaire filled out by the respondents. The sample selection used simple random sampling. The method of research used descriptive statistics using SPSS and Structural Equation Modeling (SEM). The descriptive analysis shows that the level of OCB, Work Satisfaction, Transformation Leadership, Work Motivation, and Organization Culture are at a positive level. The results of relationship among variables stated that the Transformational Leadership has no significant impact on OCB, Work Motivation has significant impact on OCB, Organization Climate has significant impact on OCB, Work Motivation has significant impact on Work Satisfaction, Organization Climate has significant impact on Work Satisfaction, Transformational Leadership has significant impact on Work Satisfaction, Transformational Leadership has no significant impact on Work Motivation, Organization Climate has significant impact on Work Motivation, and Work Satisfaction has significant impact on OCB.
Indonesian Language Acquisition for Japanese Descendants in Sanur-Bali
Authors: Pradhana Ngurah Indra
Published: June 2019

In social interaction with indigenous people (Indonesian people), Japanese people must equip themselves with Indonesian language skills to establish good communication. The same is true of the descendants of those who will make association with Indonesian children. In this case Indonesian is very important to be taught so that children of Japanese descent can interact and live well with the surrounding community. This is what attracts researchers to find out, patterns or ways of Japanese society in teaching Indonesian to their children. This research was conducted in the Sanur area, Denpasar City, Bali. This study uses the theory of sociology of language, teaching Indonesian, and using a questionnaire as a tool to obtain data. The results of this study reveal that the teaching pattern used consists of two types, namely the naturalistic and the formal type. While teaching Indonesian to his children, he found several problems. One of them is the complexity of using polite language and special expressions when communicating to each person in their respective positions. From the parameters of language skills, the most important thing to be taught to children of Japanese descent is the ability to speak (conversation).
Algebraic Lexicon Grammar
Authors: De Bueriis Giustino , Langella Alberto Maria
Published: June 2019

This article aims at showing an application of graph theory to the description of the syntactic relations between words in English. Graph theory is part of Network Science, a new and compelling branch of mathematics that has undergone huge development over the past 20 years. The linguistic theoretical background is the Lexicon Grammar (LG) that in turn is built on the ground of the Harrisian grammar for operators and arguments. Graph theory is particularly useful in order to show how sentences have underlying structures that can be visualized through the use of graphs, and whose properties can be measured and quantified with the typical mathematical tools used by the researchers in the field of Network Science. A graph is a set of nodes (also called ‘vertices’) and links (also called ‘edges’); the links connect the nodes. Each sentence will be described as a graph, in which the words have to be seen as the nodes and the syntactic relations between the words are the links.
Perilous Wages: Predicaments of Female Labour Migration from Bangladesh to the Middle East
Authors: Islam M. Saiful
Published: June 2019

The recent bilateral agreement between Bangladesh and the Gulf Cooperation Countries (GCC) has facilitated migration of female domestic workers, which has opened up an opportunity as well as challenge for Bangladesh. Opportunities are quite significant in a sense that male migration has already been saturated in the GCC countries which has a major impact on the flow of remittances. The abundant and employable female labour force in Bangladesh could easily contribute to this international labour migration, and thereby add to the national economic development. There are serious problems as well since many Bangladeshi female domestic workers are reported to be exploited, sexually abused and raped by the middle man, recruiting agents, and the overseas employers. Many women fled from their employer and sought shelter at the Bangladesh consulate in Jeddah and Riyadh, alleging that they are either being tortured, not properly fed, paid, or not given job as promised. Many female migrants left their family members and young children at home in Bangladesh, which created further social problems as women are still considered as homemakers and childcare providers in the Bangladeshi cultural context. At this backdrop, the time is up to find out ways to make female domestic migration safe and secure. Both the sending and receiving countries must come up with policies and awareness programs that would ensure safety for the female domestic workers. It requires a strong commitment from both the sending and receiving countries that the policies, acts and laws are in favour of female migrant workers. National and international NGOs, civil society and media could play vital role to adopt and implement appropriate policies for safe and sound migration of the female domestic workers.
Preoperative Warming Reduces Intraoperative Hypothermia in Total Joint Arthroplasty Patients
Authors: Kay Andrew B. , Klavas Derek M. , Hirase Takashi , Cotton Michael O. , Lambert Bradley S. , Incavo Stephen J.
Published: June 2019

Introduction:

Perioperative hypothermia (PH) is common in patients undergoing total joint arthroplasty (TJA). A previous study at our institution identified the largest drop in core body temperature between preoperative holding and induction of anesthesia. This study evaluates the effect of preoperative warming measures on PH in TJA patients.

Methods:

A retrospective review was conducted of 672 patients undergoing TJA at our institution between April 1 and October 31, 2017. Under the new normothermia protocol, patients received warmed intravenous fluids and forced-air warming gowns in the preoperative holding area. Time and temperature data for the perioperative period were collected from the electronic health record. Chi-square and paired t-tests were used to compare between total knee arthroplasty and total hip arthroplasty patients and between new and old protocols.

Results:

In the new protocol, 173 of 672 (26%) patients were hypothermic at incision compared with 140 of 383 (37%) patients in the previous protocol (P < 0.05). The largest drop in core body temperature occurred between preoperative holding and induction of anesthesia. The duration of time from operating room entry to incision was less for normothermic than for hypothermic patients. The duration of hypothermia was similar between new and old protocols overall, but markedly fewer total hip arthroplasty patients remained hypothermic for the entire surgery under the new protocol.

Conclusion:

Adding forced-air warming preoperatively to our warming protocol reduced the rate of PH by approximately 30%. The time from entry into the operating room to the start of surgery should be minimized because patients are vulnerable to PH during this interval.
Beliefs of Life Cycle in the Cultural Life of Ethnic Minorities in Northwestern Vietnam in Current Context
Authors: Loi Le Van , Lan Hoang Thi
Published: June 2019

Beliefs of Life cycle (or life cycle - related beliefs) of ethnic minorities in the Northwestern region of Vietnam are the beliefs related to the lives of people in this region from birth to death which carried out through basic rituals such as: the rituals in childbirth, marriage, funeral and rituals of treatment, etc. The beliefs of life cycle plays an important role in the cultural life of ethnic minorities: helping people have psychological balance before the steps of birth – old age – sickness – death in the human life; a place that aspires for a peaceful, happy life and maintains the emotional attachment between generations and with the community; a place that preserves many cultural values with humanity, morality, ethic values and unique artistic values, contributing to the cultural nuances of ethnic groups in the Northwestern region. In the current context, the life cycle beliefs of ethnic minorities in the Northwestern region are having a strong recovery, creating conditions for good cultural values of this kind of beliefs to promote the role in cultural life of ethnic minorities. However, the tendency of recovery both prolix and expensive rituals and miscellaneous cultural features, unsound customs as well as outdated habits are posing many challenges, requiring effective solutions to preserve and promote the good cultural values in this kind of beliefs of ethnic minorities in the Northwestern mountainous region of Vietnam in the current context.
Goal Ambiguity in Public Organizations: A Systematic Literature Review
Authors: Botti Antonio , Monda Antonella
Published: June 2019

In the literature on the public-private organizations is well known that public organizations have more ambiguous elements than private ones, such as ideology and objectives, that negatively influence the enthusiasm (Brunsson, 1986), motivation and performance of public employees (Pandey & Raney, 2006), as well as organizational performance (Chun & Raney, 2005). The close relationship with performance led many public administration scholars to deepen the concept of goal ambiguity in public management. However, given the lack of a univocal conceptualization of the phenomenon, the present work aims to contextualize goal ambiguity in the public administration, carrying out a systematic literature review. The results bring out goal ambiguity methods of measurement, its antecedents and consequences and the relationship between goal ambiguity and performance. From a theoretical point of view, the study allows systematizing the contributions on goal ambiguity, while from a practical point of view, a thorough knowledge of the concept allows public managers and policy-makers to obtain valuable information for the achievement of good organizational performance.
Factors Affecting Service Share Prices at Amman Stock Exchange
Authors: Aziz Farid Saymeh Abdul , Mohamad Salameh Rashed
Published: June 2019

The research objective was to identify the determinants of services stock prices. Research community was represented by the service companies listed in Jordan’s Amman Stock Exchange (ASE). The companies were selected to whose shares continued trading during the study period (2010-2015). The study sample was composed of (27) shareholding companies which were listed on the Amman Stock Exchange (ASE) during the afore mentioned period.

The study results revealed that there was a significant impact of the factors selected such as: profits (distributed profits, return on assets and net cash flows from operations) on the market value of service companies share prices listed on ASE.

The study recommended that further studies ought to be conducted to specify the factors that might affect the market value of listed companies’ shares.
The Relationship between LBOs, IPOs and Market Risk Premium: An Empirical Analysis of the European Market
Authors: Salvi Antonio , Teti Emanuele , Giakoumelou Anastasia
Published: June 2019

This paper investigates the relationship between leveraged buyouts (LBOs) and initial public offerings (IPOs) with the market risk premium in the European market. We expand our study to the period spanning from the first quarter of 1999 to the fourth quarter of 2016. Our longitudinal analysis finds evidence of an inverse relationship between market risk premium and the volume of LBOs, as well as a direct relationship between the latter and the stock index STOXX Europe 600. Additionally, our analysis of IPO operations confirms the significance of all factors considered in predicting the IPO trends in Europe, with a persisting accentuated impact generated by the market risk premium and the stock index STOXX Europe 600, also in this case. While previous analyses majorly focused on the US market, this paper is among first attempts to examine the topic of interest in the European context.
Challenges and Opportunities Associated with Whole Grains Use in Twin Cities Restaurants: A Food Systems Perspective
Authors: Ringling Keagan , Yangas Alexander , Riley Melissa , Korczak Renee , Marquart Len
Published: June 2019

Increasing whole grain (WG) availability in restaurants allows consumers to make healthier choices with minimal effort while improving adherence to the Dietary Guidelines. To understand challenges associated with increasing WG availability in Twin Cities (Minneapolis & St. Paul, Minnesota, USA) restaurants, interviews and focus groups were conducted with 24 local, national, and international food system members. This report identifies food system barriers, including policy, business, and societal pressures, that limit availability of WG based foods in restaurants. Insight provided by this study allows consortium members from various sectors and disciplines to work on a precompetitive basis to include more WG in Twin Cities restaurants.
Quantitative Ethobotany of Gnetum africanum Welw. (Gnetaceae) in Massoumboum, Littoral Region of Cameroon
Authors: Betti Jean Lagarde , Fils Pascal Eric Billong , Toffon Prisca , Wété Eric , Ngueguim Jules Romain , Njimbam Oumar Farick , Womeni Stéphanie Tientcheu
Published: June 2019

Gnetum africanum Welw. is a plant specie of Central and West Africa, a Non Timber Forest Product (NTFP) with high nutritional, medicinal and economic value. In Cameroon, its leaves are recognized by the forestry administration as a special product. Strong demand combined with destructive harvesting techniques has resulted in its rarity in its distribution area. The objective of this work is to characterize the harvesting and trade of G. africanaum, and to assess its abundance (density and structure) in order to appreciate the economic value of the Lehman agroforest system (ALM) based in Massoumboum, a village located at 30 Km of Douala town, the economical capital of Cameroon. An ethnobotanical survey was conducted among harvesters and sellers of G. africanum in the ALM and in adjacent markets. An inventory of G. africanum stems and leaves was carried out at an overall sampling rate of 9.52%. The study revealed that, harvesting of G. africanum is freely done by women, youngers and elders. They start their activity early in the morning and convey their products to markets located in the periphery and inside the city of Douala. The price of the gramme is too high in the periphery than in the city, averaging 0.58 CFA franc. This price is high in the dry season due to the scarcity of other agricultural vegetables. The inventories conducted revealed densities of 6 191 stems/ha and 119 548 leaves/ha, with the high density of leaves obtained in less perturbed plots. The combination of field data (forest inventories) with those obtained in the markets (trade data), what we call « quantitative ethnobotany », allowed us to appreciate the temporal economic value (EV) of the ALM. This EV ranges from 500 000 - 700 000 CFA franc, for an average value of 37 059.9 CFA franc /ha. If well managed, G. africanum can contribute not only to the economy of the women-harvesters, but also to the economy of the ALM. The glaring development challenge of the background of what precedes is the development of non-detriment findings (NDF) for G. africanum in Cameroon. These consist of setting tools which aims to sustain the resource and trade such as the delimitation of Gnetum Allocation Units (GAU), as well as the development and implementation of simple management plans (SMPs).
Exploração econômica do látex da hevea brasiliensis no desenvolvimento da região norte do Brasil
Authors: Brito Rui Rodrigues de , Vieira Thiago Almeida
Published: June 2019

A humanidade vive num planeta finito, com recursos naturais também finitos, as relações da evolução da sociedade com o meio ambiente, pela agilidade e intensidade das intervenções antrópicas, caracterizam-se por um descompasso com os ciclos naturais, o desgaste e a degradação da natureza ocorrem de forma acelerada, sem que ela tenha tempo de resiliência. Este trabalho procura colaborar na tarefa de aprofundar a discussão sobre  desenvolvimento regional sustentável, visando conciliar o desenvolvimento econômico da exploração do Látex com a conservação do meio ambiente, com objetivo geral de investigar a exploração econômica do látex no desenvolvimento da Região Norte do Brasil, apresentando a seringueira (Hevea brasiliensis) como instrumento de desenvolvimento sustentável, evidenciado com exploração do látex como um negócio socioambiental de longo prazo. Para realização do presente estudo foi realizado uma revisão de literatura sobre a temática com fundamento em diversos autores para tomada de decisão da pesquisa exploratória, consistindo na explicitação das teorias e conceitos que ajudaram na compreensão do objeto da pesquisa em questão. A exploração econômica proveniente da extração do látex da seringueira na Região Norte do Brasil é uma atividade tradicional, presente desde muitas décadas. E por muitos anos dominou a economia regional, o que se faz necessário em tempos atuais uma pesquisa sobre a temática do que já foi a base econômica da região. Com a realização do presente trabalho constatou-se que a exploração econômica do látex da seringueira tem se mostrado não só como um negócio lucrativo, mas também um instrumento de desenvolvimento sustentável viável para Região Norte do Brasil. Os problemas do meio ambiente são globais, mas as soluções são locais, e em tempos atuais a humanidade caminha para desenvolver técnicas de conservação e preservação do ar, da água e do solo para combater os problemas ambientais que venham a prejudicar qualquer que seja a parte integrante do meio ambiente, agregando as dimensões sociais, ecológicas, tecnológicas e econômicas ao meio ambiente.
Avaliação rápida de rios e nascentes como instrumento de análise ambiental urbana e rural
Authors: Rezende Jozrael Henriques , De Luca Melissa Valiente
Published: June 2019

Este trabalho teve como objetivo aplicar dois protocolos de avaliação rápida para classificação dos cursos d’água e das nascentes da Bacia Hidrográfica do Córrego dos Pires em Jaú/SP. Esta bacia possui 15,45 km² de área total, sendo 79,6% no perímetro urbano e 51,8% apresentando alto grau de impermeabilização do solo. Para o estudo de caso foram selecionados o protocolo de avaliação rápida de rios adaptado por Callisto et al. (2002) e o protocolo de avaliação rápida de nascentes proposto por Gomes et al. (2005). Em relação ao grau de preservação das cinco nascentes avaliadas uma foi classificado como “boa”, uma como “regular” e três como “ruins”. Para a avaliação dos trechos dos cursos d’água foi proposta uma recategorização em sete níveis, permitindo desta forma a diferenciação minuciosa do estado de cada trecho. As categorias ou estado dos trechos definidos na proposta foram: “natural”, “seminatural”, “alterado”, “muito alterado”, “impactado”, “altamente impactado” e “degradado”. Dos doze trechos avaliados um foi enquadrado como “natural”, dois como “seminaturais”, dois como “alterados”, dois como “muito alterados” e cinco como “impactados”. Os resultados demonstraram a eficácia na utilização destes protocolos na avaliação ambiental da bacia hidrográfica. As situações encontradas e a classificação quanto aos impactos ambientais macroscópicos nas nascentes e em cada trecho dos cursos d’água podem ser úteis nos processos de tomada de decisão para a gestão ambiental urbana e a sustentabilidade das cidades.
Avaliação da conformidade físico-química e microbiológica da água tratada e distribuída no município de Santana/AP
Authors: Furtado Rafael Neri , Cunha Helenilza Ferreira Albuquerque , Xisto da Silva Geison Carlos , Cunha Alan Cavalcanti da
Published: June 2019

Um dos principais déficits de serviços de saneamento básico brasileiro, especialmente na região Norte, é a frequente não-conformidade de qualidade da água tratada e distribuída. O objetivo desta investigação é avaliar indicadores físico-químicos e microbiológicos da água ofertada no município de Santana, o 2º mais importante do Estado do Amapá-AP. A metodologia consistiu em monitorar 15 sítios usando amostras de água de consumo humano, aleatoriamente espacializados, com frequência amostral bimestral durante 24 meses. Os parâmetros avaliados foram: pH, Turbidez, Fe, NO3, Mg, F, NH3, Al, Coliformes Totais (CT) e Escherichia coli (EC). As amostras foram coletadas exclusivamente em domicílios servidos pela Companhia de Água e Esgoto do Amapá (CAESA). Os resultados das análises foram comparados com padrões da Portaria N° 2914/2011 do Ministério da Saúde. Exceto F, NO3 e NH3, todos os demais apresentaram não-conformidade em relação a legislação vigente (pH=100%, Turbidez=57%, Fe=71,4%, Mn=28,5% e Al=100%, CT=100% e Ecoli=57,1). Testes estatísticos (PCA e Friedman-χ2, p<0,05) confirmam a hipótese de significativa variação espaço-sazonal físico-química e microbiológica da qualidade da água na malha urbana de Santana-AP. Concluímos, portanto, que a produção e a distribuição da água da CAESA estão comprometidas, necessitando de ajustes e adequação às normas e legislações vigentes no Brasil.
L-methionine sulfoximine interacted with propofol and showed toxicity in PC12 cells
Authors: Guan Ruicong , Chen Jing , Xiao Fei , Xie Yubo
Published: June 2019

Background: L-Methionine sulfoximine (MSO) inhibits glutamine synthesis in a rodent animal model, and its limited clinical use is implicitly associated with glutamate deprivation and neurotoxicity. The purpose of this experiment was to determine the effect of MSO on pheochromocytoma (PC12) cells and its interaction with propofol-induced neuro-apoptosis. Objective: To study the effects of MSO on cell viability following 100 μM propofol treatment and the impact of ribosomal S6 kinase 1 (RSK1) signaling on the PC12 cell line. Methods: PC12 cells were exposed to propofol-triggered neurotoxicity for 6 h and then subjected to MSO treatment. The gene and protein expression levels of members of the RSK1 signaling pathway were determined by real-time polymerase chain reaction, Western blot and histological analyses. The CCK8 test was used to assess cell viability, and cell proliferation and apoptosis were evaluated by flow cytometric analysis. Results: Propofol, a gamma-aminobutyric acid (GABA) agonist widely used in general anesthesia, significantly changed the expr ession level of cAMP response element-binding protein (CREB) and B cell lymphoma 2 (Bcl2) and solute carrier family 1 member 3 (Slc1a3), but not extracellular signal-regulated kinase 1/2 (ERK1/2). PC12 cells that were exposed to propofol for more than 6 h exhibited downregulation of RSK1. MSO aggravated the toxicity of propofol in PC12 cells via inhibition of the p90RSK1/CREB/Bcl2 signaling pathway.
Sequencing data discovery with MetaSeek
Authors: Hoarfrost Adrienne , Brown Nick , Brown C. Titus , Arnosti Carol
Published: June 2019

Sequencing data resources have increased exponentially in recent years, as has interest in large-scale meta-analyses of integrated next-generation sequencing datasets. However, curation of integrated datasets that match a user’s particular research priorities is currently a time-intensive and imprecise task. MetaSeek is a sequencing data discovery tool that enables users to flexibly search and filter on any metadata field to quickly find the sequencing datasets that meet their needs. MetaSeek automatically scrapes metadata from all publicly available datasets in the Sequence Read Archive, cleans and parses messy, user-provided metadata into a structured, standard-compliant database, and predicts missing fields where possible. MetaSeek provides a web-based graphical user interface and interactive visualization dashboard, as well as a programmatic API to rapidly search, filter, visualize, save, share, and download matching sequencing metadata.

The MetaSeek online interface is available at https://www.metaseek.cloud/. The MetaSeek database can also be accessed via API to programmatically search, filter, and download all metadata. MetaSeek source code, metadata scrapers, and documents are available at https://github.com/MetaSeek-Sequencing-Data-Discovery/metaseek/.

Additional guides, tutorials, and documents are available at https://github.com/MetaSeek-Sequencing-Data-Discovery/metaseek, and on the MetaSeek website, https://www.metaseek.cloud/. MetaSeek is distributed under an MIT license.
Report of candidatus Mycoplasma haematoparvum and Mycoplasma haemocanis canine natural infections in Massambaba restinga, Brazil
Authors: Miranda Marcia Gonçalves , Alberigi Bruno , Mendes-de-Almeida Flavya , Bendas Alexandre José Rodrigues , Almosny Nadia , Paiva Jonimar Pereira , Labarthe Norma Vollmer
Published: June 2019

Background: Tick-borne diseases are frequent in the Southeastern section of Brazil. The most prevalent canine parasites diagnosed are Ehrlichia canis, Babesia gibsoni, Babesia canis and Anaplasma platys, although Mycoplasma haemocanis and candidatus Mycoplasma haematoparvum have been registered in the country.

Methods: When two clinically healthy dogs from a suburban area of the state of Rio de Janeiro, Brazil with history of being heavily infested with ticks were examined at Idexx Reference Laboratories, California for tick panel check.

Results: One dog harbored DNA of candidatus Mycoplasma haematoparvum and the other DNA of Mycoplasma haemocanis.

Conclusions: These results suggest that monitoring for tick infestations and tick-borne parasites must be permanent in southeastern Brazil, especially due to global climate changes which may contribute to spread and increase the number of infections in the Country.
Identification of a genome-specific repetitive element in the Gossypium D genome
Authors: Lu Hejun , Cui Xinglei , Zhao Yanyan , Magwang Richard Odongo , Li Pengcheng , Cai Xiaoyan , Zhou Zhongli , Wang Xingxing , Liu Yuling , Xu Yanchao , Hou Yuqing , Peng Renhai , Wang Kunbo , Liu Fang
Published: June 2019

The activity of genome-specific repetitive sequence is the main cause of the genome variation between Gossypium A and D genomes. Through the comparative analysis of the two genomes, we got a repetitive element (ICRd motif), which repeats massively in the diploid Gossypium raimondii (D5) genome while almost absent in the diploid Gossypium arboreum (A2) genome. We further explored the existence of ICRd motif in G. raimondii, G. arboreum, and two tetraploids (AADD) cotton G. hirsutum and G. barbadense by fluorescence in situ hybridization (FISH), and observed the ICRd motif exists in D5 and D-subgenomes but not in A2 and A-subgenome. The ICRd motif was investigated through its two constituents , a length variable tandem repeat region (TR) and a conservative sequence (CS), which highly repeat and evenly distribute in chromosomes of D5 genome. The ICRd motif was revealed as the common conservative region of ancient LTR-TEs. The identifications and investigation of the ICRd motif promote the study on the A and D genome differences, facilitate the research on the Gossypium genome evolution, and provide assistance to subgenome identification and genome assembling.
Kirjandus tehnikaajastul / Literature in the Age of Technology
Authors: Männiste Indrek , Tomberg Jaak
Published: June 2019

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N. Katherine Haylesi posthumanistlik vaade digitaalsele kirjandusele. Saatesõna tõlkele / N. Katherine Hayles' Post-human View of Digital Literature. Foreword to the translation
Authors: Tomberg Jaak
Published: June 2019

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Intermediatsioon: ühe visiooni kannul / Intermediation: The Pursuit of a Vision
Authors: Hayles N. Katherine , Rattasepp Silver
Published: June 2019

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Antibacterial Activity of Fresh Red and White Onion (Allium cepa) Extract against Some Drug Resistant Bacteria
Authors: Anyaegbunam K. Zikora , Amaechi L. Ogara , AnyaegbunamTito C. , Wisdom O. Oniwon , Henrietta C. Ogechukwu , Cosmas S. , Sabinus I. Ofoefule
Published: June 2019

Antibiotics resistance is currently one of the major challenges in the health care system. The antimicrobial properties of some herbs have been used in the treatment of infectious diseases as well as disinfection of surfaces. This in a way helps overcome microbial resistance arising from indiscriminate use of synthetic antimicrobial agents for similar purpose. Some antibiotic resistant bacteria- Pseudomonas aeruginosa, Staphylococus aureus and Escherichia coli isolated from cooking wares in homes were investigated using agar well diffusion and agar dilution method to test for the antibacterial activity of fresh Allium cepa (onion) extract. All were susceptible to the fresh white and red onion extract except Staphylococus aureus which was susceptible to only the white onion extract. The diameter of zones of inhibition ranged from 2 mm-35 mm. The Minimum Inhibitory Concentration (M. I. C.) and the Minimum Bacterial Concentration (M. B. C.) values of the fresh onion juices against the test bacteria were low ranging from 3.125% v/v – 25.0% v/v. This study indicates that the fresh raw extracts of Allium cepa possess significant antibacterial potency against these antibiotic resistant bacteria.
Uses for humanised mouse models in precision medicine for neurodegenerative disease
Authors: Nair Remya R. , Corrochano Silvia , Gasco Samanta , Tibbit Charlotte , Thompson David , Maduro Cheryl , Ali Zeinab , Fratta Pietro , Arozena Abraham Acevedo , Cunningham Thomas J. , Fisher Elizabeth M. C.
Published: June 2019

Neurodegenerative disease encompasses a wide range of disorders afflicting the central and peripheral nervous systems and is a major unmet biomedical need of our time. There are very limited treatments, and no cures, for most of these diseases, including Alzheimer’s Disease, Parkinson's Disease, Huntington Disease, and Motor Neuron Diseases. Mouse and other animal models provide hope by analysing them to understand pathogenic mechanisms, to identify drug targets, and to develop gene therapies and stem cell therapies. However, despite many decades of research, virtually no new treatments have reached the clinic. Increasingly, it is apparent that human heterogeneity within clinically defined neurodegenerative disorders, and between patients with the same genetic mutations, significantly impacts disease presentation and, potentially, therapeutic efficacy. Therefore, stratifying patients according to genetics, lifestyle, disease presentation, ethnicity, and other parameters may hold the key to bringing effective therapies from the bench to the clinic. Here, we discuss genetic and cellular humanised mouse models, and how they help in defining the genetic and environmental parameters associated with neurodegenerative disease, and so help in developing effective precision medicine strategies for future healthcare.
Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer
Authors: Hashiguchi Yojiro , Muro Kei , Saito Yutaka , Ito Yoshinori , Ajioka Yoichi , Hamaguchi Tetsuya , Hasegawa Kiyoshi , Hotta Kinichi , Ishida Hideyuki , Ishiguro Megumi , Ishihara Soichiro , Kanemitsu Yukihide , Kinugasa Yusuke , Murofushi Keiko , Nakajima Takako Eguchi , Oka Shiro , Tanaka Toshiaki , Taniguchi Hiroya , Tsuji Akihito , Uehara Keisuke , Ueno Hideki , Yamanaka Takeharu , Yamazaki Kentaro , Yoshida Masahiro , Yoshino Takayuki , Itabashi Michio , Sakamaki Kentaro , Sano Keiji , Shimada Yasuhiro , Tanaka Shinji , Uetake Hiroyuki , Yamaguchi Shigeki , Yamaguchi Naohiko , Kobayashi Hirotoshi , Matsuda Keiji , Kotake Kenjiro , Sugihara Kenichi ,   Japanese Society for Cancer of the Colon and Rectum
Published: June 2019

The number of deaths from colorectal cancer in Japan continues to increase. Colorectal cancer deaths exceeded 50,000 in 2016. In the 2019 edition, revision of all aspects of treatments was performed, with corrections and additions made based on knowledge acquired since the 2016 version (drug therapy) and the 2014 version (other treatments). The Japanese Society for Cancer of the Colon and Rectum guidelines 2019 for the treatment of colorectal cancer (JSCCR guidelines 2019) have been prepared to show standard treatment strategies for colorectal cancer, to eliminate disparities among institutions in terms of treatment, to eliminate unnecessary treatment and insufficient treatment and to deepen mutual understanding between healthcare professionals and patients by making these guidelines available to the general public. These guidelines have been prepared by consensuses reached by the JSCCR Guideline Committee, based on a careful review of the evidence retrieved by literature searches and in view of the medical health insurance system and actual clinical practice settings in Japan. Therefore, these guidelines can be used as a tool for treating colorectal cancer in actual clinical practice settings. More specifically, they can be used as a guide to obtaining informed consent from patients and choosing the method of treatment for each patient. Controversial issues were selected as clinical questions, and recommendations were made. Each recommendation is accompanied by a classification of the evidence and a classification of recommendation categories based on the consensus reached by the Guideline Committee members. Here, we present the English version of the JSCCR guidelines 2019.
Enhancement of l-arginine production by increasing ammonium uptake in an AmtR-deficient Corynebacterium crenatum mutant
Authors: Xu Meijuan , Li Jing , Shu Qunfeng , Tang Mi , Zhang Xian , Yang Taowei , Xu Zhenghong , Rao Zhiming
Published: June 2019

l-Arginine is an important amino acid with extensive application in the food and pharmaceutical industries. The efficiency of nitrogen uptake and assimilation by organisms is extremely important for l-arginine production. In this study, a strain engineering strategy focusing on upregulate intracellular nitrogen metabolism in Corynebacterium crenatum for l-arginine production was conducted. Firstly, the nitrogen metabolism global transcriptional regulator AmtR was deleted, which has demonstrated the beneficial effect on l-arginine production. Subsequently, this strain was engineered by overexpressing the ammonium transporter AmtB to increase the uptake of NH4+ and l-arginine production. To overcome the drawbacks of using a plasmid to express amtB, Ptac, a strong promoter with amtB gene fragment, was integrated into the amtR region on the chromosome in the Corynebacterium crenatum/ΔamtR. The final strain results in l-arginine production at a titer of 60.9 g/L, which was 35.14% higher than that produced by C. crenatum SYPA5-5.
The Housing Cycle: What Role for Mortgage Market Development and Housing Finance?
Authors: Agnello Luca , Castro Vitor , Sousa Ricardo M.
Published: June 2019

We use duration analysis to assess the impact of securitization, mortgage sector liberalization and government involvement in housing finance on the length of housing booms, busts and normal times in a panel of 20 OECD countries over the period 1970Q1-2015Q4. Our results reveal that a move towards a more liberalized mortgage sector is associated with longer housing booms, while an increase in securitization is linked with shorter housing busts. They also show that the length of housing booms and busts is particularly sensitive to housing finance characteristics, but that does not seem to be the case for normal times. Additionally, government support measures do not necessarily cushion against housing busts. A careful assessment of their distributional impact, as well as their effect on the trade-off between liquidity and guarantee/loan provision, is also required to prevent (longer) housing booms. All in all, housing finance regulation may prove especially relevant to shield against the damaging effects of housing busts and the financial stability risks associated with housing booms. Monetary policy can also be an important complement to macro-prudential policies. Finally, government participation in housing finance should be designed in a way that avoids an undesirable amplification of house price fluctuations.
Privacy preserving semantic trajectory data publishing for mobile location-based services
Authors: Tan Rong , Tao Yuan , Si Wen , Zhang Yuan-Yuan
Published: June 2019

The development of wireless technologies and the popularity of mobile devices is responsible for generating large amounts of trajectory data for moving objects. Trajectory datasets have spatiotemporal features and are a rich information source. The mining of trajectory data can reveal interesting patterns of human activities and behaviors. However, trajectory data can also be exploited to disclose users’ privacy information, e.g., the places they live and work, which could be abused by a malicious user. Therefore, it is very important to protect the users’ privacy before publishing any trajectory data. While most previous research on this subject has only considered the privacy protection of stay points, this paper distinguishes itself by modeling and processing semantic trajectories, which not only contain spatiotemporal data but also involve POI information and the users’ motion modes such as walking, running, driving, etc. Accordingly, in this research, semantic trajectory anonymizing based on the k-anonymity model is proposed that can form sensitive areas that contain k − 1 POI points that are similar to the sensitive points. Then, trajectory ambiguity is executed based on the motion modes, road network topologies and road weights in the sensitive area. Finally, a similarity comparison is performed to obtain the recordable and releasable anonymity trajectory sets. Experimental results show that this method performs efficiently and provides high privacy levels.