bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Media Kartu Gambar terhadap Kemampuan Menulis Puisi Siswa Kelas IV SDN Sirnagalih
Authors: Septianti Vena , Saleh Yopa Taufik , Pratiwi Anggia Suci
Published: January 2025

Learning to write is one of the fundamental aspects in developing language skills. By learning to write effective poetry, students can improve their ability to express ideas better in written form. The use of word card media in learning to write poetry can overcome problems that occur during learning because word card media can increase students’ creativity in writing so that students are able to express their imagination and feelings into poetry. This research uses a quantitative approach with a quasi-experimental design. The population in this study was all 26 class IV students at SDN Sirnagalih. For the research sample, the control group consisted of 13 students, and the experimental group consisted of 13 students. With a sampling technique using simple random sampling. Based on the research results, the data in this study is normally distributed and homogeneous with a data normality significance level of 0.827 > 0.05 and a data homogeneity significance level of 0.846 > 0.05. Hypothesis testing in this research uses the independent sample t-test. Based on the results of the hypothesis test, the significance value obtained was 0.000 < 0.05. So it can be concluded that there is an influence of picture card media on the poetry writing ability of grade IV students at SDN Sirnagalih.
Pengaruh Model Problem Based Learning terhadap Keterampilan Menulis Teks Eksposisi pada Siswa Kelas VIII SMP Negeri Naiola
Authors: Opat Ermelinda Elu , Kristanti E , Kharisma Giri Indra
Published: January 2025

Learning to write expository texts is one of the lessons that students need to master. Students are required to be able to convey strong ideas or arguments accompanied by facts in accordance with the structure and linguistic characteristics of expository texts. To achieve this goal, there needs to be an appropriate learning model. This research aims to determine the influence and response of students to the application of the Problem Based Learning model in learning to write expository texts in class VIII of SMPN Naiola, North Central Timor Regency, NTT. This research is a pre-experimental research with a one-group pretest-posttest design. Data collection is through pretest and posttest procedures as well as questionnaires. Sampling used random sampling technique. Data analysis uses descriptive statistical tests, prerequisite tests, hypothesis tests and N-Gain tests. The research results obtained a tcount value of 7,247>2,160 (ttable). Thus it can be concluded that the problem based learning model has a very significant influence in improving the ability to write expository texts with a significance value of 0.000>0.05 and students' responses to the probem based learning model are also very good.
Limitações na Graduação em Enfermagem ante o Aprendizado sobre Sexualidade na Adolescência
Authors: Ederson Moreira do Nascimento David , Felix Batista Kylyane , Tavares de Luna Neto Raimundo , Bastos Ferreira Tavares Natália , Flávio Freitas de Souza Kaio , Karolinne da Silva Costa Hysadora , Fernanda Faccio Patrícia , Valdinéia Marques de Vasconcelos Maria
Published: January 2025

A adolescência é uma fase em que ocorre transformações complexas, como a puberdade, onde o corpo começa a se desenvolver e se tornar apto para as práticas sexuais e reprodutivas. Se objetivou identificar como o aprendizado sobre sexualidade na adolescência é abordado durante a graduação em enfermagem e quais são as limitações existentes. Pesquisa exploratória e descritiva, de abordagem qualitativa, sendo caracterizada como um estudo de campo, desenvolvida entre os meses de outubro a dezembro de 2021 em duas universidades do Brasil, estas que ofertam o curso de graduação em enfermagem. Participaram do estudo 11 estudantes de enfermagem, selecionados a partir do 7º semestre por meio do método de amostragem não probabilística por acessibilidade ou conveniência. Para a coleta dos dados foi utilizado um roteiro de entrevista semiestruturada, contendo cinco tópicos para a condução da discussão, onde, posteriormente, tais dados foram submetidos à análise de conteúdo proposta por Minayo. A pesquisa seguiu os princípios bioéticos dispostos na resolução 466/12 que trata de estudos envolvendo seres humanos, bem como, as normas do Ofício Circular 2/2021 que traz orientações específicas para procedimentos em pesquisa com qualquer etapa em ambiente virtual. Constatou-se que ainda são frágeis os pilares de ensino, pesquisa e extensão sobre a temática estudada, havendo importantes limitações no processo de ensino-aprendizagem dos graduandos de enfermagem. O estudo trouxe à tona a importância de os cursos de graduação em enfermagem refletirem as grades curriculares e o processo formativo sobre a saúde sexual e as suas relações com a adolescência.
Representações Sociais de Racismo no Futebol em matérias jornalísticas
Authors: Guerra dos Santos Denise , Pereira Lima Rita de Cássia , Da Silva Triani Felipe
Published: January 2025

O objetivo deste artigo é discutir representações sociais sobre racismo no futebol, veiculadas em matérias jornalísticas, a partir do caso ocorrido na Espanha em maio de 2023, com o atleta negro brasileiro Vinícius Júnior. Foram selecionados oito títulos de matérias publicadas em jornais brasileiros online durante seis dias de cobertura do caso acontecido no futebol espanhol. Apresentamos uma pesquisa documental com análise do discurso, utilizando o referencial teórico metodológico da Teoria das Representações Sociais, a fim de apontar o campo consensual e as tomadas de posição dos atores envolvidos, considerando que o objeto “racismo no futebol” pode estar presente em um universo subjetivo e cotidiano da sociedade. As discussões deflagraram posturas ambíguas sobre racismo no futebol, apresentadas pelos diferentes atores sociais, trazendo para o campo consensual um enfrentamento aparente, sem indicar maiores transformações no combate ao racismo.
Dispositivos Amorosos, Repetição de Padrão Familiar e Relacionamento Abusivo: Impactos e Atravessamentos
Authors: Vasconcelos Bernardino Adriana , Pardal de Matos Beatriz , Leal Vieira da Rosa Camila
Published: January 2025

Este estudo propõe uma revisão bibliográfica com delineamento qualitativo e visa analisar criticamente acerca da tríade: Dispositivos amorosos, repetição de padrões familiares e relacionamentos abusivos. Por esse viés, discute a influência da estrutura patriarcal e machista nos desdobramentos das violências, a construção da família sob interferência da Igreja e do Estado e as modificações do papel da mulher na sociedade. Assim, explora as expectativas para cada indivíduo vide os dispositivos de gênero baseados na cultura e na transmissão geracional considerando o silêncio como elemento protetor dos mitos familiares, ocultador de abusos e perpetuador de padrões. Por fim, reflete sobre o papel do psicólogo e a necessidade de uma formação crítica e atenta aos atravessamentos políticos, históricos, culturais e familiares nas vivências de cada sujeito, buscando contribuir com o despertar de profissionais preocupados com um viés de transformação social para uma psicologia mais potente.
Palavras-chaves: Transmissão geracional; relacionamento abusivo; gênero; repetição; violência
Abordagem Lúdica Presente nos Livros Didáticos do Ciclo de Alfabetização
Authors: Marafon Danielle , De Lima  Calegari Kuligowski Jessica
Published: January 2025

Esta pesquisa tem por finalidade demonstrar a articulação do lúdico com a alfabetização e o letramento a partir dos livros didáticos dos 1º e 2º anos do Ensino Fundamental- Anos Iniciais. Nesse sentido, reconhecer a especificidade da alfabetização, entendida como processo de aquisição e apropriação do sistema da escrita, alfabético e ortográfico em um contexto de letramento – utilizando-se de jogos e brincadeiras como subsídios metodológicos para a efetivação dessa prática. Deste modo, esta investigação procura analisar as linguagens e os recursos que são considerados lúdicos, em cada obra didática. Assim esse estudo se se constitui numa abordagem qualitativa, por meio de pesquisa bibliográfica e documental. Percebemos, portanto que as atividades lúdicas quando são inseridas nos contextos escolares podem propiciar uma metodologia mais efetiva para a apropriação dos conteúdos, que acabam produzindo conhecimento por meio das brincadeiras.
Envelhecimento, Velhice LGBTI+ e Mulheres Encarceradas: Suas Representações Sociais Durante o Contexto Pândemico
Authors: Maria Fernanda Lima Silva  , Da Silva Alves Mateus Egilson , Ludgleydson Fernandes de Araújo  , Lana Carine Soares Dias Camelo  , Jefferson Luiz de Cerqueira Castro  , Evair Mendes da Silva Sousa
Published: January 2025

Objetivou-se com este estudo apreender as representações sociais (RS) da velhice LGBTI+ e do envelhecimento saudável entre mulheres encarceradas. Participaram 14 mulheres encarceradas com idades entre 21 e 53 anos (média de sentença de 130,42 meses). Para a coleta de dados utilizou-se: I) questionário sociodemográfico, II) entrevista semiestruturada e III) técnica de associação livre de palavras (TALP) a partir do estímulo ‘velhice LGBTI+’. A análise dos dados se deu através dos softwares SPSS para o I e Iramuteq para o II e III. Obteve-se um dendrograma com quatro classes e uma TALP com ordem média de evocação de 2,96. As RS revelam formas de pensar e conhecimentos do universo das partícipes sobre as temáticas abordadas interseccionadas às experiências e vivências dessa população. Considera-se que o contexto pandêmico elevou dificuldades e percas como interrupção de laços familiares, acesso à atendimentos em saúde e sentimentos negativos como sofrimento, abandono e tristeza
Prática Pedagógica do Jiu-Jítsu para Crianças com Autismo
Authors: Maria da Silva Leitão Luisa , Lucio da Silva Thiago , Silva de Andrade Marconi , Da Silva Triani Felipe
Published: January 2025

O ensino do Jiu-Jitsu baseado em valores é um aspecto importante a ser estudado, valores como irmandade, integridade e desenvolvimento são transmitidos aos praticantes, incentivando a cooperação, respeito, disciplina, autoestima e liderança. A prática regular do Jiu-Jitsu para crianças autistas pode promover o desenvolvimento de habilidades motoras, cognitivas, sociais e emocionais. O objetivo desse estudo é apresentar estratégias pedagógicas nas aulas de Jiu-Jitsu para crianças com autismo, numa perspectiva baseada em valores. A pesquisa adotou uma metodologia foi a pesquisa bibliográfica. A análise de dados foi realizada por meio de estudos em artigos relacionados ao tema. Conclui-se que o Jiu-Jitsu pode transmitir valores importantes e proporcionar benefícios físicos, sociais e emocionais para crianças autistas, sua prática pedagógica adaptada pode ser uma forma eficaz de intervenção terapêutica e educacional, promovendo uma melhor qualidade de vida para a criança.
Perfil Sociodemográfica e de Risco Cardiovascular entre Policiais do Batalhão de Operações Especiais (BOPE) e Unidades Convencionais no Rio de Janeiro
Authors: De Freitas Marçolla Vanessa , Campos de Albuquerque Denilson , Cavalcanti de Oliveira Dinaldo , Brito de Aragão Alexandre Augustus , Picone Borges de Aragão Ivana , Ferreira Esmeralci
Published: January 2025

O Rio de Janeiro registrou 38.172 mortes por doenças cardiovasculares em 2016. Os policiais militares são expostos ao adoecimento agravados pelos fatores de risco cardiovascular (FR) e pelo estresse. Há poucos dados de literatura comparando FR em diferentes categorias da Polícia Militar do Estado do Rio de Janeiro (PMERJ). Este estudo, tem por objetivo primário avaliar aspectos sociodemográficos e FR entre o Batalhão de Operações Policiais Especiais (BOPE) e outros policiais de unidades convencionais. Inclusão: homens em atividade policial. Estudo quantitativo, observacional, transversal, com 400 policiais militares: GI= 200 BOPE e GII = 200 policiais de unidades convencionais, entre agosto/2017 até dezembro/2018. Utilizados questionários: FR, autopercepção do estresse e Inventário de Sintomas de Stress (ISS) de LIPP. Resultados: Faixa etária prevalente: 35-44 anos em ambos os grupos, mas no GI eram mais idosos (p= 0,01). Hipertensão: 15,1% (GI) e 6,5% (GII), p= 0,01; diabetes 1,5% (GI) e 4,5% (GII), p=0,14;  etilismo 11,6% (GI) e 6,0% (GII), p<0,05;  sedentarismo 17,6% (GI) e 17,9% (GII), p=1,0; tabagistas ativos 19,1% (GI) e 54,2% (GII), p=0,01; histórico familiar  25,6%(GI)  e 21,4% (GII), p=0,34; circunferência abdominal 97,0 (GI) 95,8 (GII), p=0,02;  colesterol 229,6(GI) e 209,6(GII), p=0,01. O estresse foi referido como moderado em ambos os grupos (GI – 42,7% e GII – 43,8%), p=0,61 e o ISS foi semelhante. O escore de Framinghan foi baixo em ambos os grupos (1,3%, p=0,57).  Conclusões:  os policiais do BOPE apresentaram maior prevalência de FR, mas sem apresentar diferenças nos parâmetros de estresse, tampouco elevado escore de risco de doença coronariana.
Estratégias de Enfrentamento (Coping) em Pessoas com Doença de Crohn
Authors: Oliveira de Araujo Gustavo , Da Costa de Carvalho Mendes Gisele , Raiane de Araújo Gleyde , Da Silva Alves Mateus Egilson , Campos de Almeida Maycon , Nascimento da Silva Paulo Gregório , De Medeiros Emerson Diógenes
Published: January 2025

A Doença de Crohn (DC) é uma doença autoimune, de caráter crônico e incurável, que está enquadrada no quadro de Doenças Inflamatórias Intestinais (DII). É considerado um quadro complexo com implicações psicológicas significativas na vida dos indivíduos. Nessa linha, as estratégias de coping são consideradas recursos importantes no enfrentamento à DC. Objetivou-se conhecer as estratégias de enfrentamento utilizadas por pessoas com DC. Trata-se de uma pesquisa qualitativa, descritiva e exploratória, realizada com 17 pessoas com diagnóstico de DC e idades entre 18 a 40 anos. A análise dos dados foi feita por meio da análise de conteúdo temática de Bardin. Resultaram 3 classes de categorias temáticas em que discute-se os impactos psicológicos da doença, a convivência e adaptação psicossocial pós-diagnóstico e o uso de diferentes estratégias de enfrentamento frente aos estressores, principalmente, por meio do coping religioso e espiritual, entretenimento e apoio familiar e social.
Estratégias de Ensino do Badminton para Alunos com Deficiência
Authors: Jucá Luan Gonçalves , Lima George Almeida , Moura Diego Luz
Published: January 2025

Este estudo objetivou compreender as estratégias de ensino do Badminton para alunos com deficiência. Utilizou-se a revisão integrativa. A coleta de dados aconteceu nas bases: Scielo, Lilacs, BDTD, Periódicos Capes e Google Scholar. Foram analisados cinco artigos. Os resultados apontam que a inclusão dos alunos está alinhada com o processo de adaptação das atividades, considerando as capacidades dos alunos. Conclui-se que o Badminton se apresenta como uma prática de fácil acesso, possibilitando a participação dos(as) alunos(as) a partir da realização de adaptações.
Oxidative Stress Biomarkers in Hypertension
Authors: Fountoulakis Petros , Kourampi Islam , Theofilis Panagiotis , Marathonitis Anastasios , Papamikroulis Georgios Angelos , Katsarou Ourania , Marinos Georgios , Oikonomou Evangelos , Siasos Gerasimos , Tousoulis Dimitris
Published: January 2025

Arterial hypertension is a silent and progressive disease with deleterious vascular
implications on all target organs, including the heart, the brain, the kidneys, and
the eyes. Oxidative stress, defined as the overproduction of Reactive Oxygen Species
(ROS) over antioxidants, is capable of deteriorating not only the normal endothelial but
also the cellular function with further cardiovascular implications. Xanthine oxidase activity,
NADPH oxidase overexpression, and ROS production lead to hypertension and
high arterial tone, culminating in end-organ damage. The inactivation of NO by superoxide
reduces vasodilation and promotes peroxynitrite formation, which damages cellular
components. Activation of MMPs by oxidative stress contributes to pathological neovascularization
and angiogenesis. Salucin-β-induced activation of Angiotensin-II and
NADPH results in vascular remodeling and fibrosis, while lipid peroxidation and PARP-
1 activation further exacerbate cellular apoptosis and vascular calcification. Moreover,
to reliably assess the oxidative status an emerging number of biomarkers are under investigation.
Antioxidant therapy, alongside traditional antihypertensive agents such as
beta-blockers and ACE inhibitors, offers the potential to mitigate oxidative stress and its
detrimental effects. Additionally, polyphenols, found in plant-based foods, show
promise in managing oxidative stress in hypertensive patients although this data has not
been confirmed in randomized clinical trials. Understanding the intricate relationship between
oxidative stress and hypertension underscores the importance of developing comprehensive
therapeutic strategies to reduce cardiovascular risk and improve patient outcomes.
Integrated in Silico and in Vitro Studies of Rutin's Potential against
SARS-CoV-2 through the Inhibition of the RNA-dependent RNA
Polymerase
Authors: Metwaly Ahmed M. , El-Fakharany Esmail M , Alsfouk Aisha A. , Ibrahim Ibrahim M. , Elkaeed Eslam B. , Eissa Ibrahim. H.
Published: January 2025

Introduction:

In our quest to identify potent inhibitors against SARS-CoV-2,
an extensive investigation was conducted for the binding and inhibitory efficacy of
Rutin against nine SARS-CoV-2 proteins.

Method:

The first step of our analysis involved a comprehensive examination of structural similarity among the co-crystallized ligands associated with those proteins. A substantial structural similarity was observed between Rutin and Remdesivir, the ligand of
the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp). This similarity was validated through a flexible alignment study. Molecular docking studies, involving superimposition, revealed a notable resemblance in the mode of binding between Rutin and Remdesivir inside the active site of the RdRp. A 200 ns molecular dynamics (MD) simulation
confirmed that the RdRp-Rutin complex is more stable than the RdRp-Remdesivir complex.

Result:

The MM-GBSA studies showed that Rutin had much more favorable binding energies, with a significantly lower value of -7.76 kcal/mol compared to Remdesivir's
-2.15 kcal/mol. This indicates that the RdRp-Rutin binding is more robust and stable
PLIP and ProLIF studies helped clarify the 3D binding interactions and confirmed the
stable binding seen in MD simulations. PCAT gave more insights into the dynamic behavior of the RdRp-Rutin complex. in vitro tests showed that Rutin has a strong inhibitory effect on RdRp with an IC50 of 60.09 nM, significantly outperforming Remdesivir,
which has an IC50 of 24.56 µM. Remarkably, against SARS-CoV-2, Rutin showed a superior in vitro IC50 of 0.598 µg/ml compared to Remdesivir (12.47 µg/ml).

Conclusion:

The values of the selectivity index underscored the exceptional margin of
safety of Rutin (SI: 1078) compared to Remdesivir (SI: 5.8). In conclusion, our comprehensive analysis indicates Rutin’s promising potential as a potent SARS-CoV-2 RdRp inhibitor, providing a valuable insight for developing an effective COVID-19 treatment.
Nanomaterials for Temporomandibular Joint Osteoarthritis Therapy:
A Mini-Review
Authors: Chen Lulu , Liao Chengcheng
Published: January 2025

Osteoarthritis, particularly temporomandibular joint (TMJ) osteoarthritis (OA), poses
significant challenges in diagnosis and treatment. Recent studies suggest that nanomaterials hold
considerable promise in treating TMJ-OA, showing validated efficacy in animal models. However, further research is required to ensure their long-term safety within the TMJ-OA environment. Nanomaterials can facilitate drug delivery and encapsulate functional cells and extracellular vesicles, offering new avenues for exploration. This paper reviews the current research status
of nanomaterials in TMJ-OA treatment, including drug delivery, anti-inflammatory, lubricating
and buffering, antioxidant, tissue regeneration, scaffold, and stimuli-responsive nanomaterials.
Additionally, the paper explores the development and future prospects of nanomaterials in TMJOA treatment, highlighting their unique contributions and aiming to provide new perspectives
and solutions for unexplored areas
Advances in the Study for Modulators of Transient Receptor Potential Vanilloid (TRPV) Channel Family
Authors: Wang Yajing , Shi Yingying , Zuo Minmin , Yu Yingcong , Huang Xianfeng
Published: January 2025

Transient receptor potential vanilloid (TRPV) channels are a member of the TRP superfamily,
which consists of six proteins and is expressed in many neuronal and non-neuronal cells.
Among them, TRPV1-4 are non-selective cation channels that are highly sensitive to temperature
changes, while TRPV5-6 are channels that are highly selective to Ca2+. These cation channels have
attracted great interest academically, especially from a pharmacological perspective. TRPV channels
play a vital role in many physiological processes and can be regulated by a variety of endogenous
stimuli as well as a range of natural and synthetic compounds. The regulation of their activities
can lead to a variety of diseases and disorders, such as neurodegenerative diseases, pain, cancer,
and skin diseases. In fact, several TRPV1 and TRPV3 modulators have been developed for
clinical use. Therefore, the development of TRPV channel modulators has important clinical significance
and value. Herein, we focused on and summarized the latest research progress of endogenous
and exogenous ligands of six TRPV channels and their pharmacological effects on related
diseases.
Ufmylation: a potential modification for neurological diseases
Authors: Che Guanglu , Xiao Xiao , Li Tingyu , Li Jingdong , Gao Linbo
Published: January 2025

Neurological disorders are the leading health threats worldwide, characterized by impairments
in consciousness, cognition, movement, and sensation, and can even lead to death. UFMylation
is a novel post-translational modification (PTM) that serves as an important regulatory factor,
promoting the complexity of protein structures and enhancing the diversity and specificity of functions.
In UFMylation, ubiquitin-fold modifier 1 (UFM1) is covalently transferred to the primary
amine of a lysine residue on the target protein through the synergistic action of three enzymes: the
activating enzyme E1 of UFM1, the coupling enzyme E2 of UFM1, and the ligase E3. UFMylation
has been proven to be involved in various cellular processes, such as the maintenance of genome
homeostasis, autophagy, signal transduction during antiviral responses, cell death, and differentiation.
Additionally, a growing number of evidence suggests that polymorphisms in genes related to
the UFMylation system are associated with the risk of epileptic encephalopathy, microcephaly, neurodegenerative
diseases, and schizophrenia. Therefore, the concept, enzymatic cascade, and biological
functions of UFMylation are carefully summarized, along with its potential role in neurological
diseases.
An Improved and Practical Approach to the Synthesis of Terbinafine as an Anti-Fungal Agent
Authors: Satteyyanaidu V. , Reddy P. Naveen , Gajula Srinivas , Poojitha U. , Nalla Ganesh , Reddy B. V. Subba
Published: January 2025

An improved strategy for the synthesis of terbinafine has been developed through the crosscoupling
of (E)-aminovinyl chloride with tert-butyl acetylene using 1 mol% of 5% Pd/C as a recyclable
heterogeneous catalyst under mild conditions. This is the first report on the Pd/C catalyzed
Sonogashira coupling to produce the 99.9% pure terbinafine under mild conditions.
Benzimidazole-phenoxy-1,2,3-triazole-benzyl Derivatives as the New Potent α-glucosidase Inhibitors: Design, Synthesis, In Vitro, and In Silico Biological Evaluations
Authors: Soltani Arash , Shirzad Hadi , Panji Mohammad , Motevaseli Elahe , Mousavinezhad Seyyed Amin , Kalbasi Saeed
Published: January 2025

Background::

α-Glucosidase inhibitors play an important role in the treatment of type 2 diabetes mellitus. Inhibitors of the latter enzyme that are available on the market creat-ed gastrointestinal side effects and achieve to a high potent and low side effect potent α-glucosidase inhibitors is a valuable target for medicinal chemists. Objective: In this study, de-rivatives of benzimidazole-phenoxy-1,2,3-triazole-benzyl skeleton were introduced as new α-glucosidase inhibitors.

Methods::

Twelve derivatives 8a-l of target scaffold were synthesized via simple chemical re-actions with a yield between 65 and 88%. The in vitro α-glucosidase inhibition activities of these compounds was evaluated against yeast form of this enzyme. After the determination of most potent compound, the interaction of this compound with α-glucosidase was evaluated in vitro by kinetic study and in silico by docking study. Drug-likeness, pharmacokinetics, and toxicity profiles of the most potent compound were predicted by an online software.

Results::

Anti-α-glucosidase assay demonstrated that all synthesized derivatives 8a-l were more potent that standard inhibitor acarbose. Representatively, 2-(4-((1-benzyl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-1H-benzo[d]imidazole (compound 8a) as the most potent deriv-ative was 150-times more potent than positive control. Kinetic study of compound 8a re-vealed that this compound is an uncompetitive inhibitor against α-glucosidase. Furthermore, molecular docking study showed that compound 8a with favorable binding energy attached to important residues in the α-glucosidase active site. This compound also can be an oral drug with favorable toxicity profile.

Conclusion::

Benzimidazole-phenoxy-1,2,3-triazole-benzyl derivatives 8a-l synthesized and evaluated for anti-α-glucosidase activity. All these compounds were excellent α-glucosidase inhibitor, and compound 8a demonstrated the most significant inhibition effect when com-pared with positive control.
Understanding Efficacy of Using ACEIs and ARBs in Chronotherapeutic
Treatment of Hypertension: Which Drug When?
Authors: Yadav Jasmine , Khan Naim , Das RIna , Mehta Dinesh Kumar
Published: January 2025

Hypertension, a prevalent global health issue, poses significant risks for morbidity and
mortality. The interplay between hypertension and comorbidities like diabetes and chronic kidney
disease (CKD) underscores the urgency for effective management strategies. Chronotherapy, aligning
medication administration with circadian rhythms, emerges as a promising approach to optimize
treatment outcomes.

The objective of this study is to assess the safety and efficacy of the use of ACEIs and ARBs in
the chronotherapeutic treatment of hypertension. We aim to clarify the influence of circadian
blood pressure patterns on the efficacy of medications and investigate the potential of chronotherapy
in the management of hypertension by conducting a thorough examination of the existing literature.

A literature search spanning from January 1980 to 2023 was conducted using PubMed, Scopus
and Google Scholar databases. Search terms included ACE inhibitors, ARBs, chronotherapy, hypertension,
and circadian rhythm of blood pressure. Studies investigating the effects of chronotherapy
with ACEIs and ARBs in hypertensive patients were analyzed.

Chronotherapy offers a personalized approach to hypertension management, leveraging the dynamic
nature of circadian rhythms. By administering ACEIs or ARBs at night, the risk of morning
blood pressure surges, associated with adverse cardiovascular events, can be mitigated. However,
the optimal timing and combination of medications remain areas of ongoing research.

Our review highlights the potential of chronotherapy with ACEIs and ARBs as a promising avenue
for hypertension treatment. Further research is warranted to elucidate the mechanisms underlying
circadian blood pressure regulation and optimize chronotherapeutic strategies. This comprehensive
evaluation underscores the need for personalized treatment approaches tailored to individual
circadian rhythms for improved hypertension management and reduced cardiovascular risk.
Women’s Satisfaction with the Provision of Prenatal Service by the Care Providers: A Cross-Section Analytical Study
Authors: Ganji Zahra , Simbar Masoumeh , Zahrani Shahnaz Tork , Borumandnia Nasrin , Kiani Zahra
Published: January 2025

Background:

Assessment of women's satisfaction with the quality of prenatal care
(PNC) services leads to identifying the needs and planning the appropriate interventions for quality
improvement. This study aimed to assess women's satisfaction with the provision of prenatal service
by the midwife and non-midwifery PNC providers and the related factors.

Methods:

This was an analytical cross-sectional study on 200 pregnant women for prenatal care
services. The participants were recruited using a multi-stage sampling method. The tools for data
collection were a demographic and fertility questionnaire and a questionnaire for the assessment of
clients' satisfaction with the quality of prenatal care services. The questionnaires were completed by
the participants in their last weeks of pregnancy and following six PNC visits. T T-test, ANOVA
analyzed data, Pearson's correlation and Multiple linear regression tests and using SPSS-24.

Results:

The total score of satisfaction with the quality of PNC services was 68.99 ± 9.54 percent.
There was no significant correlation between the women's satisfaction with demographic and fertility
variables (p>0.05). However, the T-test showed that women’s satisfaction with the care provided
by midwives is significantly higher than that provided by non-midwifery personnel. Multiple linear
regression showed that providing PNC by the midwives substantially increases the total satisfaction
score by 42.48 compared to the non-midwifery personnel.

Conclusion:

Providing PNC by midwives increases satisfaction compared to non-midwife PNC
providers. Therefore, the provision of care during pregnancy by midwives who are specifically
trained for perinatal care services is emphasized to improve women's satisfaction and the quality of
PNC services, which is necessary to reduce mortality and maternal and neonatal complications.

result:

The total score of satisfaction with the quality of PNC services was 68.99±9.54 percent. There was no significant correlation between the women's satisfaction with demographic and fertility variables (p>0.05). However, the T-test showed that women’s satisfaction with the provided care by midwives is significantly higher than that provided care by non-midwifery personnel. Multiple linear regression showed that providing PNC by the midwives significantly increased the total satisfaction score by 42.48 compared to the non-midwifery personnel.
Lightweight Lung-nodule Detection Model Combined with Multidimensional Attention Convolution
Authors: Huang He-He , Zhao Yuetao , Wei Sen-Yu , Zhao Chen , Shi Yu , Li Yuan , Huang Weijia , Yang Yifei , Xu Jianhua
Published: January 2025

Background:
Early and timely detection of pulmonary nodules and initiation treatment can substantially improve the survival rate of lung carcinoma. However,
current detection methods based on convolutional neural networks (CNNs) cannot easily detect pulmonary nodules owing to low detection
accuracy and the difficulty in detecting small-sized pulmonary nodules; meanwhile, more accurate CNN-based models are slow and require high
hardware specifications.

Objective:
The aim of this study is to develop a detection model that achieves both high accuracy and real-time performance, ensuring effective and timely
results.

Methods:
In this study, based on YOLOv5s, a concentrated-comprehensive convolution (C3_ODC) module with multidimensional attention is designed in
the convolutional layer of the original backbone network for enhancing the feature-extraction capabilities of the model. Moreover, lightweight
convolution is combined with weighted bidirectional feature pyramid networks (BiFPNs) to form a GS-BiFPN structure that enhances the fusion of
multiscale features while reducing the number of model parameters. Finally, Focal Loss is combined with the normalized Wasserstein distance
(NWD) to optimize the loss function. Focal loss focuses on carcinoma-positive samples to mitigate class imbalance, whereas the NWD enhances
the detection performance of small lung nodules.

Results:
In comparison experiments against the YOLOv5s, the proposed model improved the average precision by 8.7% and reduced the number of
parameters and floating-point operations by 5.4% and 8.2%, respectively, while achieving 116.7 frames per second.

Conclusion:
The proposed model balances high detection accuracy against real-time requirements.
A Comparative Study of CT-Guided Radiofrequency Ablation and Targeted Therapy: Intervention Efficacy and Survival Rates in Lung Cancer Patients
Authors: Zhao Tianyu , Zhang Chunjing , Dai Hang , Li Jingyu , Hao Liguo , Liu Yanan
Published: January 2025

Objective:

The study aimed to evaluate the clinical efficacy of CT-guided radiofrequency ablation in conjunction with targeted therapy in lung cancer
patients.

Methods:

We retrospectively analyzed 80 lung cancer patients. They were stratified into the Observation Group (OG; n=40, treated with CT-guided
radiofrequency ablation in conjunction with targeted therapy) and the Control Group (CG; n=40, treated solely with targeted therapy).

Results:

The Overall Response Rate (ORR) and Disease Control Rate (DCR) in the OG group (70.00%, 95.00%) were significantly higher than those in the
CG group (57.50%, 87.50%). After 6 weeks of treatment, the OG group had significantly lower levels of SCC, CEA, and CA125, higher CD4+
levels, and lower CD8+ levels, compared to the CG group. The 24-month follow-up survival rate of the OG group (47.50%) was significantly
higher than that of the CG group (27.50%).

Conclusion:

CT-guided radiofrequency ablation and targeted therapy have been proven effective in treating lung cancer.

result:

The OG group reported 4 cases of Complete Response (CR), 24 cases of Partial Response (PR), 10 cases of Stable Disease (SD), and 2 cases of Progressive Disease (PD). The Overall Response Rate (ORR) was 70.00% (28/40), and the Disease Control Rate (DCR) was 95.00% (38/40). In contrast, the CG group exhibited 3 cases of CR, 20 cases of PR, 12 cases of SD, and 5 cases of PD. The ORR was 57.50% (23/40), and the DCR was 87.50% (35/40). The ORR and DCR in the OG group were significantly higher than those in the CG group. After 6 weeks of treatment, the levels of SCC, CEA, and CA125 in the OG group were significantly lower than those in the CG group; The CD4+ levels in the OG group were significantly higher and the CD8+ levels significantly lower than those in the CG group. A 24-month follow-up showed that the survival rate of the OG group was 47.50% (19/40), which was significantly higher than that of the CG group at 27.50% (11/40).
Perforated Meckel's Diverticulum in an Adult that Resembles Acute Appendicitis: A Case Report and Review of the Literature
Authors: Bakhsh Noha , Banjar Mai
Published: January 2025

Background:

Perforation is one of the rarest effects of Meckel's diverticulum and may clinically resemble acute appendicitis.

Case Report:

A 34-year-old woman with pain in the right iliac fossa, nausea, and vomiting for three days was brought to the emergency department. An
abdominal examination indicated rebound tenderness in the area of the right iliac fossa. Abdominal ultrasound showed a heterogeneous lesion in
the left iliac fossa measuring 5 cm × 3.5 cm × 4 cm with no internal vascularity. Abdominal Computed Tomography (CT) demonstrated a
hypodense lesion located left of the midline of the abdomen, which was inseparable from the small bowel at the antimesenteric border.
Laparoscopic exploration was performed, and an intraoperative diagnosis of perforated Meckel’s diverticulum with phlegmon formation was made.
The patient had an uneventful recovery.

Conclusion:

Radiologists should be aware of the possibility of complicated Merkel's diverticulum when encountering cases of acute abdominal pain. If there is
a lower abdominal inflammatory process and a normal appendix is identified, there should be a high degree of suspicion when examining the CT
scan.
FedPneu: Federated Learning for Pneumonia Detection across Multiclient Cross-Silo Healthcare Datasets
Authors: Sharma Shagun , Guleria Kalpna , Dogra Ayush
Published: January 2025

Background:

Pneumonia is an acute respiratory infection that has emerged as the predominant catalyst for escalating mortality rates worldwide. In the pursuit of
the prevention and prediction of pneumonia, this work employs the development of an advanced deep-learning model by using a federated learning
framework. The deep learning models rely on the utilization of a centralized system for disease prediction on the medical imaging data and pose
risks of data breaches and exploitation; however, federated learning is a decentralized architecture which significantly reduces data privacy
concerns.

Methods:

The federated learning works in a distributed architecture by sending a global model to clients rather than sending the data to the model. The
proposed federated deep learning-based FedPneu computer-aided diagnosis model has been implemented in 2, 3, 4, and 5 clients architecture for
early pneumonia detection using X-ray images. The key parameters configuration include batch size, learning rate, optimizer, decay, momentum,
epochs, rounds, and random-split as 32, 0.0001, SGD, 0.000001, 0.9, 10, 100, and 42, respectively.

Results:

The results of the proposed federated deep learning-based FedPneu model have been provided in terms of round-wise accuracy, loss, and
computational time. The highest accuracy of 85.632% has been achieved with 2-clients federated deep learning architecture, whereas, 3, 4, and 5
clients architecture achieved 85.536%, 76.112%, and 74.123% accuracies, respectively.

Conclusion:

In the proposed privacy-protected federated deep learning-based FedPneu model, the two-client architecture has been resulted as the most optimal
framework for pneumonia detection among 3-clients, 4-clients, and 5-clients architecture. The model works in a collaborative and privacyprotected
framework with a multi-silo dataset which could be highly beneficial for healthcare departments to maintain patient’s data privacy with
improved prediction outcomes.
Displaced Femoral Neck Fractures Treated with Percutaneous Compression Plates in Elderly Individuals: An Effect Analysis Based on Imaging
Authors: Liu Huli , Zhao Kai , Yang Ying , Dai Liansheng , Gu Sanjun , Li Haifeng , Liu Yu
Published: January 2025

Background:

The effects of percutaneous compression plate (PCP) internal fixation for femoral neck fractures (FNFs) in elderly individuals have rarely been
reported. Therefore, this study aimed to investigate the efficacy of PCCP internal fixation for displaced FNFs in elderly individuals based on
imaging.

Methods:

The clinical data of 32 elderly patients with FNFs treated with PCCP from January 2015 to December 2022 were retrospectively analyzed. The
average age of the participants was 68.7 ± 4.8 years (range, 65–80 years). Nineteen patients had Garden type III, and 13 patients had Garden type
IV. Six patients had Pauwels type I, 15 patients had type II, and 11 patients had type III. Twelve patients had Singh index level IV, 14 patients had
level V, and 6 patients had level VI. The time from injury to operation ranged from 3–14 days, with an average of 5.8 days. A radiological
assessment was conducted. The relationships between efficacy and age, Pauwels classification, the Singh index, and the Garden alignment index
were analyzed.

Results:

At postoperative week 1, fracture reduction was acceptable in 31 patients. The time to start walking was 5.7 ± 3.7 days. The follow-up time ranged
from 2.1 to 4 years, with an average of 2.7 years. There were 2 cases of delayed healing and no cases of nonunion or internal fixation failure. The
healing time ranged from 4–8 months, with an average of 4.9 months. Fifteen patients (46.9%) showed healing with shortening of the femoral
neck, and 3 patients (9.4%) had avascular necrosis (AVN). Correlation analysis revealed that healing with shortening of the femoral neck was
positively correlated with age and the Singh index and that AVN was positively correlated with the Pauwels classification (p < 0.05).

Conclusion:

The efficacy of PCCPs for internal fixation of displaced FNFs in elderly individuals without severe osteoporosis is satisfactory, especially for
patients who can ambulate early postoperatively. The main complications are healing with shortening of the femoral neck and AVN, which are
prone to occur in patients with severe osteoporosis and Pauwels type III FNFs, respectively.
Enhanced Detection of Colon Diseases via a Fused Deep Learning Model with an Auxiliary Fusion Layer and Residual Blocks on Endoscopic Images
Authors: Kumar Rakesh , Anand Vatsala , Gupta Sheifali , Almogren Ahmad , Bharany Salil , Altameem Ayman , Rehman Ateeq Ur
Published: January 2025

Background:

Colon diseases are major global health issues that often require early detection and correct diagnosis to be effectively treated. Deep learning
approaches and recent developments in medical imaging have demonstrated promise in increasing diagnostic accuracy.

Objective:

This work suggests that a Convolutional Neural Network (CNN) model paired with other models can detect different gastrointestinal (GI)
abnormalities or diseases from endoscopic images via the fusion of residual blocks, including alpha dropouts (αDO) and auxiliary fusing layers

Methods:

To automatically diagnose colon disorders from medical images, this work explores the use of a fused deeplearning model that incorporates the
EfficientNetB0, MobileNetV2, and ResNet50V2 architectures. By integrating these features, the fused model aims to improve the classification
accuracy and robustness for various colon diseases. The proposed model incorporates an auxiliary fusion layer and a fusion residual block. By
combining diverse features through an auxiliary fusion layer, the network can create more comprehensive and richer representations, capturing
intricate patterns that might be missed by single-source processing. The fusion residual block incorporates residual connections, which help
mitigate the vanishing gradient problem. By adding the input of the block directly to its output, these connections facilitate better gradient flow
during backpropagation, allowing for deeper and more stable training. A wide range of endoscopic images are used to assess the proposed model,
offering an accurate depiction of various disease scenarios

Results:

The proposed model, with an auxiliary fusion layer and residual blocks, exhibited an enormous reduction in overfitting and performance saturation.
The proposed model achieved an impressive 98.03% training accuracy and 97.90% validation accuracy after evaluation, outperforming the
majority of typically trained DCNNs in terms of efficiency and accuracy.

Conclusion:

The proposed method developed a lightweight model that correctly identifies disorders of the gastrointestinal (GI) tract by combining advanced
techniques, including feature fusion, residual learning, and self-normalization.
Synthesis, Antimicrobial Activity, DFT, Molecular Docking, and Dynamic
Simulations of Trityl Mannopyranoside Derivatives for Potential
Antibacterial Agents
Authors: Akter Sabina , Kawsar Sarkar M. A. , Bouzid Gassoumi , Horchani Mabrouk , Bulbul Md Z.H. , Ghalla Houcine , Jannet Hichem Ben , Saha Supriyo , Fujii Yuki , Uddin Kabir M. , Bhat Ajmal R. , Ahmed Sumeer , Ozeki Yasuhiro
Published: January 2025

Aim:

There is an urgent need for new antimicrobial compounds with alternative modes
of action for the treatment of drug-resistant bacterial and fungal pathogens.

Background:

Carbohydrates and their derivatives are essential for biochemical and medicinal research
because of their efficacy in the synthesis of biologically active drugs.

Objective:

In the present study, a series of methyl α-D-mannopyranoside (MMP) derivatives (2-6)
were prepared via direct acylation, and their biological properties were characterized.

Methods:

The structures of synthesized compounds were established by analyzing their physicochemical,
elemental, and spectroscopic data and evaluating their in vitro antimicrobial activities
through in silico studies.

Results:

In the antibacterial study, compound 3 was found to be mostly active toward most of the
organisms, exhibiting maximum inhibition of S. abony and minimum inhibition of P. aeruginosa.
However, the MIC and MBC values revealed that this compound is highly effective against Bacillus
subtilis (MIC of 0.5 μg/L and MBC of 256 μg/L). In terms of antifungal activity, 3 and 6
showed the most promising activity toward Aspergillus flavus, with an inhibition of 95.90 ± 1.0%
for compound 3 and 96.72 ± 1.1% for compound 6. Moreover, density functional theory (DFT) in
conjunction with the BLYP/6-311G (d) basis sets was used to calculate the dipole moment and total
energy for each compound, and the molecular electrostatic potential and Mulliken charge were
considered to study the electrophilicity and nucleophilicity of the groups in each compound. For
dipole moment calculations, the dipole moments are in the following order: 6 < 3 < 1 < 5 < 2 < 4,
inferring that compounds 2 and 4 possess a high dipole moment in comparison with the other inhibitor
systems. Furthermore, molecular docking was performed against threonine synthase from B.
subtilis ATCC 6633 (PDB: 6CGQ) to identify the active site of the compounds, with compound 3
showing a maximum binding energy of -10.3 kcal/mol and compound 4 exhibiting a binding energy
of -10.2 kcal/mol. In addition, a 100 ns MD simulation was performed, and the results revealed a
stable conformation and binding pattern within the stimulating environment.

Conclusion:

Our synthetic, antimicrobial, and in silico experiments revealed that MMP derivatives
exhibit potential activity, providing a therapeutic target for bacteria and fungi.
Covalent Inhibitor Screening for Targeting LOXL2: Studied by Virtual
Screening and Experimental Validation
Authors: Lin Lirui , Lin Kai , Chen Lichun , Wang Yiwen , Xu Li-Yan , Li En-Min , Liu Qingping , Zou Haiying , Dong Geng
Published: January 2025

Background:

Lysyl oxidase-like 2 (LOXL2) is a metalloenzyme that catalyzes oxidative deamination ε-amino group of lysine. It has been found that LOXL2 is a promotor for the
metastasis and invasion in kinds of tumors. Previous studies show that disulfide bonds are important components in LOXL2, and their bioactivity can be regulated by those bonds. In this
way, a small molecule covalently binds to the thiol group of cysteine residue could be an effective way to change the function of LOXL2 by blocking the formation of the disulfide bond.

Objective:

This investigation is aiming to screen covalent inhibitor for LOXL2

Methods:

Covalent molecule libraries of Life Chemical and Enamine were used. The structures
of those molecules were optimized by using LigPrep module of Schrödinger. Then optimized by
using the LigPrep module of Schrödinger to generate optimal conformations. For covalent docking, CovDock in Glide module was used for the virtual screening. Finally, wound-healing assays
were performed to examine the effects of the potential inhibitors.

Results:

Eight potential small molecules were selected by covalent docking from the databases
(in total 7,908 candidates). ADMET evaluation indicated that all those eight small molecules
satisfy the general standard. Furthermore, wound healing experiments showed that the compound (F50972176) significantly inhibits the migration of cancer cells.

Conclusion:

Virtual screening and experimental verification methods were used to screen covalent inhibitors of LOXL2 by targeting functional disulfide bonds. The compound (F50972176)
effectively inhibited the migration of esophageal squamous cell carcinoma cells