bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Road Networks Features of Urban Municipal District Based on Fractal Dimension
Authors: Deng Hongxing , Wen Wen , Zhang Wenhui
Published: May 2023

The structural characteristics of an urban road network directly affect the urban road network’s overall function and service level. Because the hierarchical division and layout form of an urban road network has self-similarity and scale invariance, the urban traffic network has certain time-space fractal characteristics, and fractal theory has become a powerful tool for evaluating traffic networks. This paper calculates and compares five fractal dimensions (FD) of nine districts in Harbin. Meanwhile, each calculated FD is linearly regressed with the area, population, built-up area, building area, the total number and length of roads, and the number of buildings in the region. The results show that the fractal dimensions of the five types are between 1 and 2. In the same district, the values of the FD perimeter and FD ruler are lower compared to the FD box, FD information, and FD mass, whereas those of the FD box and FD information are higher. Compared to the FD box and FD information, the value of FD mass shows unevenly. Based on the current research results, this study discusses the feasibility of using relevant indicators in the fractal process to evaluate the layout of the urban road network and guide its optimization and adjustment.
A Concise Review of Prodigious Salinomycin and Its Derivatives Effective in Treatment of Breast Cancer: (2012–2022)
Authors: Soni Viren , Nagar Akhil , Bardiya Ruchita , Mara Jacob , Von Suskil Lukas , Rose Sabrina , Sonawane Chetankumar
Published: May 2023

Cancer stem cells (CSCs) are the cells in a primary tumor that have the opportunity to self-renew as well as differentiate into certain cell types, thus forming a mixed tumor. CSCs have been shown to be involved in every aspect of cancer development, including tumor initiation, proliferation, and metastatic activity; they are also involved in chemotherapeutic drug resistance and the recurrence of certain cancers. Based on these capabilities, CSCs have been explored as the next target for the treatment and management of cancer. Salinomycin (SAL), a polyether ionophore antibiotic being used in the poultry industry, was identified as a powerful anti-cancer compound that possesses broad-spectrum activities, especially against CSCs. Here we point out the noteworthy work reported on SAL’s mechanism of action, anticancer activities, toxicity, and clinic applications. In addition, SAL derivatives synthesized by different research groups and their biological activity will also be highlighted.
State of the Art on Two-Phase Non-Miscible Liquid/Gas Flow Transport Analysis in Radial Centrifugal Pumps Part C: CFD Approaches with Emphasis on Improved Models
Authors: Hundshagen Markus , Skoda Romuald
Published: May 2023

Predicting pump performance and ensuring operational reliability under two-phase conditions is a major goal of three-dimensional (3D) computational fluid dynamics (CFD) analysis of liquid/gas radial centrifugal pump flows. Hence, 3D CFD methods are increasingly applied to such flows in academia and industry. The CFD analysis of liquid/gas pump flows demands careful selection of sub-models from several fields in CFD, such as two-phase and turbulence modeling, as well as high-quality meshing of complex geometries. This paper presents an overview of current CFD simulation strategies, and recent progress in two-phase modeling is outlined. Particular focus is given to different approaches for dispersed bubbly flow and coherent gas accumulations. For dispersed bubbly flow regions, Euler–Euler Two-Fluid models are discussed, including population balance and bubble interaction models. For coherent gas pocket flow, essentially interface-capturing Volume-of-Fluid methods are applied. A hybrid model is suggested, i.e., a combination of an Euler–Euler Two-Fluid model with interface-capturing properties, predicting bubbly flow regimes as well as regimes with coherent gas pockets. The importance of considering scale-resolving turbulence models for highly-unsteady two-phase flow regions is emphasized.
Quadrilateral Mesh Generation Method Based on Convolutional Neural Network
Authors: Zhou Yuxiang , Cai Xiang , Zhao Qingfeng , Xiao Zhoufang , Xu Gang
Published: May 2023

The frame field distributed inside the model region characterizes the singular structure features inside the model. These singular structures can be used to decompose the model region into multiple quadrilateral structures, thereby generating a block-structured quadrilateral mesh. For the generation of block-structured quadrilateral mesh for two-dimensional geometric models, a convolutional neural network model is proposed to identify the singular structure inside the model contained in the frame field. By training the network model with a large number of model region decomposition data obtained in advance, the model can identify the vectors of the frame field in the region located in the segmentation field. Then, the segmentation streamline is constructed from the annotation. Based on this, the geometric region is decomposed into several small regions, regions which are then discretized with quadrilateral mesh elements. Finally, through two geometric models, it is verified that the convolutional neural network model proposed in this study can effectively identify the singular structure inside the model to realize the model region decomposition and block-structured mesh generation.
Giant Sex Chromosomes in Omophoita Species (Coleoptera, Chrysomelidae): Structural and Evolutionary Relationships Revealed by Zoo-FISH and Comparative Genomic Hybridization (CGH)
Authors: Vidal Jhon A. D. , Sassi Francisco de M. C. , de Moraes Renata L. R. , Artoni Roberto F. , Liehr Thomas , Cioffi Marcelo B. , de Almeida Mara C.
Published: May 2023

The beetles of the subtribe Oedionychina (Chrysomelidae, Alticinae) are the only ones that have the atypical giant and achiasmatic sex chromosomes, which are substantially larger than the autosomes. Previous cytogenetic analyses suggest a large accumulation of repetitive DNA in the sex chromosomes. In this study, we examined the similarity of X and Y chromosomes in four Omophoita species and compared genomic differentiation to better understand the evolutionary process and the giant sex chromosomes origin. Intraspecific genomic comparation using male and female genomes of O. octoguttata and interespecific analyses using genomic DNA of O. octoguttata, O. sexnotata, O. magniguttis, and O. personata were performed. In addition, whole chromosome painting (WCP) experiments were performed with X and Y chromosome probes of O. octogutatta. CGH analysis revealed great genomic similarity between the sexes and a sex-specific region on the Y chromosome, and interspecific analysis revealed a genomic divergence between species. In contrast, WCP results revealed that the sex chromosomes of O. octoguttata have high intra- and interspecific similarity with the studied species. Our data support a common origin under the canonical evolution of the sex chromosomes in this group, as they have high genomic similarity between them.
Reply to Cione et al. Comment on “Moshirfar et al. Accuracy of Six Intraocular Lens Power Calculations in Eyes with Axial Lengths Greater than 28.0 mm. J. Clin. Med. 2022, 11, 5947”
Authors: Moshirfar Majid , Durnford Kathryn M. , Jensen Jenna L. , Beesley Daniel P. , Peterson Telyn S. , Darquea Ines M. , Ronquillo Yasmyne Castillo , Hoopes Phillip C.
Published: May 2023

We thank Cioni et al. for their suggestions and comments [...]
Association between Low Forced Vital Capacity and High Pneumonia Mortality, and Impact of Muscle Power
Authors: Shiokawa Nanako , Okazaki Tatsuma , Suzukamo Yoshimi , Miyatake Midori , Kogure Mana , Nakaya Naoki , Hozawa Atsushi , Ebihara Satoru , Izumi Shin-Ichi
Published: May 2023

Impaired % predicted value forced vital capacity (% FVC) is related to higher all-cause mortality in aged adults, and strong muscle force may improve this relationship. A muscle disease, sarcopenia, causes higher mortality. We aimed to identify the unknown disease that relates impaired % FVC with higher mortality in aged adults among the three major leading causes of death, and the effect of strong leg force on this relationship. Cox proportional hazard model analyzed the longitudinal Tsurugaya cohort that registered 1048 aged Japanese for 11 years. The primary outcome was the relationship between % FVC and mortality by cancer, cardiovascular disease, or pneumonia. Exposure variables were % FVC or leg force divided by 80% or median values, respectively. The secondary outcome was the effects of leg force on the relationship. Among the diseases, % FVC < 80% was related only to higher pneumonia mortality (hazard ratio [HR], 4.09; 95% CI, 1.90–8.83) relative to the % FVC ≥ 80% group before adjustment. Adding the leg force as an explanatory variable reduced the HR to 3.34 (1.54–7.25). Weak leg force might indicate sarcopenia, and its prevention may improve higher pneumonia mortality risk related to impaired % FVC, which we may advise people in clinical settings.
Does Subretinal Fluid Influence Choroidal Thickness (ChT) and Structure in Preeclampsia with Serous Retinal Detachment? Comment on Fukui et al. Changes in Choroidal Thickness and Structure in Preeclampsia with Serous Retinal Detachment. J. Clin. Med. 2023, 12, 609
Authors: Marino Andrea Valerio , La Marca Aniello , De Luca Martina , D’Aniello Eleonora , Gioia Marco
Published: May 2023

We read with great interest the article by Fukui A et al. concerning the “Changes in Choroidal Thickness (ChT) and Structure in Preeclampsia with Serous Retinal Detachment” [...]
Hemophilic Arthropathy of the Knee and Its Association with Reduced Muscle Strength and Activation and the Pressure Pain Threshold: A Case-Control Study
Authors: Villalón-González Mar , Fernández de Luco-Santamaría Íñigo , Cuesta-Barriuso Rubén , López-Pina José Antonio , Pérez-Llanes Raúl
Published: May 2023

(1) Background: Hemophilia is characterized by recurrent hemarthrosis leading to degenerative arthropathy. The aim was to evaluate the differences in muscle strength and activity and the pressure pain threshold between patients with knee arthropathy and their healthy peers; (2) Methods: A case-control study in which 23 adult patients with knee arthropathy and 24 healthy peers matched in terms of characteristics were recruited. The study variables were quadriceps muscle strength, muscle activation and the pressure pain threshold; (3) Results: There were significant differences between the two groups in quadriceps strength on the dominant (CI95%: 64.69, 129.2) and non-dominant (CI95%: 29.95, 93.55) sides and in the pressure pain threshold on the dominant (CI95%: 3.30, 43.54) and non-dominant (CI95%: 3.09, 45.25) sides. There were differences in neuromuscular fatigue on the non-dominant side in the vastus medialis (CI95%: 8.72, 21.51), vastus lateralis (CI95%: 4.84, 21.66) and rectus femoris (CI95%: 6.48, 24.95) muscles; (4) Conclusions: Muscle strength and the pressure pain threshold are lower in patients with hemophilia. Quadriceps muscle activation in patients with hemophilic knee arthropathy does not in any way differ from activation in healthy subjects. However, muscle fatigue is greater in patients with knee arthropathy. Strength training in patients with hemophilia should focus on the activation of the vastus medialis and lateralis muscles.
Red Flags for Chronic Inflammatory Demyelinating Polyradiculoneuropathy Associated with Sarcoidosis or Connective Tissue Diseases
Authors: Vialatte de Pémille Clément , Noël Nicolas , Adam Clovis , Labeyrie Céline , Not Adeline , Beaudonnet Guillemette , Echaniz-Laguna Andoni , Adams David , Cauquil Cécile
Published: May 2023

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare autoimmune disorder of the peripheral nervous system. Diagnosis relies on clinical and electrophysiological criteria. Various disorders requiring specific treatment regimens may be associated with CIDP, including sarcoidosis (SAR-CIDP) and connective tissue disease (CTD-CIDP). Therefore, it is important to distinguish between CIDP, SAR-CIDP and CTD-CIDP. In this retrospective monocentric study, we analyzed 16 patients with SAR-CIDP and 11 with CTD-CIDP and compared them with a group of 17 patients with idiopathic CIDP. SAR-CIDP patients had a frequently acute or subacute CIDP onset. CTD-CIDPs were mostly Sjögren’s syndrome and lupus, and patients had a chronic onset. An older age at onset (64.5 vs. 54 years, p = 0.04), more atypical presentation (19/25 (76%) vs. 6/17 (35%), p = 0.008), acute/subacute onset of symptoms (15/25 (60%) vs. 1/17 (6%), p = 0.0004) and more frequent weight loss (7/16 (44%) vs. 0/17 (0%), p = 0.017) were identified SAR-CIDP and CTD-CIDP groups. Response to intravenous immunoglobulin therapy was lower in the combined SAR-CIDP and CTD-CIDP group (44% versus 82%, p = 0.005). As sarcoidosis and CTDs might be associated with CIDP and require specific management, the “red flags” mentioned above should be kept in mind by clinicians managing patients with CIDP.
Removal of Sub-Internal Limiting Membrane Hemorrhage Secondary to Retinal Arterial Macroaneurysm Rupture: Internal Limiting Membrane Non-Peeling Technique
Authors: Kimura Akari , Imai Hisanori , Iwane Yukako , Kishimoto Maya , Sotani Yasuyuki , Yamada Hiroko , Matsumiya Wataru , Miki Akiko , Kusuhara Sentaro , Nakamura Makoto
Published: May 2023

The appropriate surgical technique to improve the closure rate of perioperative full-thickness macular hole (FTMH) secondary to submacular hemorrhage (SMH) with sub-internal limiting membrane (ILM) hemorrhage caused by retinal arterial macroaneurysm (RAM) rupture remains an unsolved clinical problem. Several ILM transplantation techniques have been attempted, but these are challenging. Our new technique can remove sub-ILM hemorrhage with the central fovea ILM intact, without peeling the ILM. The medical records of three eyes from three patients with SMH and sub-ILM hemorrhage secondary to RAM rupture were retrospectively reviewed. During the surgery, a small ILM fissure was made outside the central fovea with ILM forceps, and sub-ILM hemorrhage was washed out through it by manually spraying balanced salt solution. Sub-ILM hemorrhage removal was achieved successfully in all eyes, with no occurrences of FTMH or other complications. Best-corrected decimal visual acuity improved from 0.05 (Snellen equivalent (SE), 20/400), 0.05 (SE, 20/400), and 0.05 (SE, 20/400) preoperatively to 0.3 (SE, 20/63), 0.4 (SE, 20/50), and 0.15 (SE, 20/125) at 3 months postoperatively, respectively. This new technique may help keep the foveal ILM intact and prevent perioperative FTMH formation.
The Clinical Significance of Serum Free Light Chains in Bladder Cancer
Authors: Gudowska-Sawczuk Monika , Kudelski Jacek , Olkowicz Michał , Młynarczyk Grzegorz , Chłosta Piotr , Mroczko Barbara
Published: May 2023

This research aimed to assess the clinical usefulness of serum kappa (κ) and lambda (λ) free light chains (FLCs) in patients with bladder cancer (BC). One hundred samples were collected and analysed from healthy volunteers (C) and bladder cancer patients. Cancer patients were divided into two subgroups: low-grade (LG) and high-grade cancer (HG). Concentrations of FLCs, CEA, CA19-9, creatinine and urea were measured per manufacturers’ guidelines. The concentrations of κ and λ FLCs and CEA were significantly higher in BC patients in comparison to the control group. Moreover, the concentrations of κ and λ FLCs and CEA were significantly higher in both low-grade as well as high-grade cancer in comparison to the controls. The levels of κ and λ FLCs differed between tumour grades, with patients presenting higher concentrations in high-grade compared to low-grade cancer. In the total study group, κFLC correlated with λFLC, the κ:λ ratio, CRP, CEA, CA19-9, creatinine and urea. There was also a correlation between λFLC and κFLC, CRP, CEA, creatinine and urea. The λFLC showed a higher ability (sensitivity and PPV) to detect bladder cancer in comparison to κFLC and CEA. In addition, λFLC had a higher ability to exclude BC (specificity and NPV) than κFLC and CEA. λFLC also showed the highest accuracy in the detection of bladder cancer. In conclusion, the revealed differences in the concentrations of both κ and λ FLCs suggest their potential participation in bladder cancer development. Increased concentrations of free light chains in bladder cancer patients and the association with the tumour grade suggest that κ and λ FLC measurements may be useful in the diagnosis and prognosis of bladder cancer. This is the first research that evaluates the concentration of FLCs in bladder cancer, so further studies are necessary to confirm their usefulness as tumour markers of this malignancy.
Assessment and Monitoring of the Quality of Clinical Pathways in Patients with Depressive Disorders: Results from a Multiregional Italian Investigation on Mental Health Care Quality (the QUADIM Project)
Authors: Monzio Compagnoni Matteo , Caggiu Giulia , Allevi Liliana , Barbato Angelo , Carle Flavia , D’Avanzo Barbara , Di Fiandra Teresa , Ferrara Lucia , Gaddini Andrea , Giordani Cristina , Sanza Michele , Saponaro Alessio , Scondotto Salvatore , Tozzi Valeria D. , Corrao Giovanni , Lora Antonio
Published: May 2023

Ensuring adequate quality of care to patients with severe mental disorders remains a challenge. The implementation of clinical indicators aimed at assessing the quality of health care pathways delivered is crucial for the improvement of mental health services (MHS). This study aims to evaluate the quality of care delivered to patients who are taken-into-care with depressive disorders by MHS. Thirty-four clinical indicators concerning accessibility, appropriateness, continuity, and safety were estimated using health care utilization databases from four Italian regions (Lombardy, Emilia-Romagna, Lazio, Sicily). A total of 78,924 prevalent patients treated for depressive disorders in 2015 were identified, of whom 15,234 were newly engaged by MHS. During the year of follow-up, access to psychotherapeutic interventions was low, while the intensity was adequate; 5.1% of prevalent patients received at least one hospitalization in a psychiatric ward (GHPW), and 3.3% in the cohort of newly engaged in services. Five-out-of-10 patients had contact with community services within 14 days after GHPW discharge, but less than half of patients were persistent to antidepressant drug therapy. Furthermore, prevalent patients showed an excess of mortality compared to the general population (SMR = 1.35; IC 95%: 1.26–1.44). In conclusion, the quality of health care is not delivered in accordance with evidence-based mental health standards. Evaluation of health interventions are fundamental strategies for improving the quality and equity of health care.
Xeno-Free Biomimetic ECM Model for Investigation of Matrix Composition and Stiffness on Astrocyte Cell Response
Authors: Saleh Bayan M. , Pourmostafa Ayda , Patrawalla Nashaita Y. , Kishore Vipuil
Published: May 2023

Astrocytes, highly specialized glial cells, play a critical role in neuronal function. Variations in brain extracellular matrix (ECM) during development and disease can significantly alter astrocyte cell function. Age-related changes in ECM properties have been linked to neurodegenerative diseases such as Alzheimer’s disease. The goal of this study was to develop hydrogel-based biomimetic ECM models with varying stiffness and evaluate the effects of ECM composition and stiffness on astrocyte cell response. Xeno-free ECM models were synthesized by combining varying ratios of human collagen and thiolated hyaluronic acid (HA) crosslinked with polyethylene glycol diacrylate. Results showed that modulating ECM composition yielded hydrogels with varying stiffnesses that match the stiffness of the native brain ECM. Collagen-rich hydrogels swell more and exhibit greater stability. Higher metabolic activity and greater cell spreading was observed in hydrogels with lower HA. Soft hydrogels trigger astrocyte activation indicated by greater cell spreading, high GFAP expression and low ALDH1L1 expression. This work presents a baseline ECM model to investigate the synergistic effects of ECM composition and stiffness on astrocytes, which could be further developed to identify key ECM biomarkers and formulate new therapies to alleviate the impact of ECM changes on the onset and progression of neurodegenerative diseases.
Understanding Inhomogeneous Mechanical Properties in PBF-LB/M Manufactured Parts Due to Inhomogeneous Macro Temperature Profiles Based on Process-Inherent Preheating
Authors: Zielinski Jonas , Theunissen Jan , Kruse Henrik , Rittinghaus Silja-Katharina , Schleifenbaum Johannes Henrich , Zhu Dongjian , Megahed Mustafa
Published: May 2023

The mechanical properties in laser-based powder bed fusion (PBF-LB/M) manufactured parts are anisotropic in nature due to the layer-wise build-up but also change due to different solidification conditions in dependence on the process strategy and the geometry. In this work, the latter effect is examined by means of simulating the thermal history on a part scale (macro temperature) and correlating the critical temperature and holding time with the local hardness and microstructure. A macro temperature model is introduced and validated with vector-based thermal simulations and thermo couple measurements from the build-up process. Two cone-shaped geometries are investigated, namely, an upright and an inverted cone. The examinations are performed and validated with Inconel 718. An outlook to further investigations and more complex, real-life applicable geometries is given.
Ultrafast Laser Additive Manufacturing: A Review
Authors: Saunders Jacob , Elbestawi Mohammad , Fang Qiyin
Published: May 2023

Ultrafast lasers are proven and continually evolving manufacturing tools. Concurrently, additive manufacturing (AM) has emerged as a key area of interest for 3D fabrication of objects with arbitrary geometries. Use of ultrafast lasers for AM presents possibilities for next generation manufacturing techniques for hard-to-process materials, transparent materials, and micro- and nano-manufacturing. Of particular interest are selective laser melting/sintering (SLM/SLS), multiphoton lithography (MPL), laser-induced forward transfer (LIFT), pulsed laser deposition (PLD), and welding. The development, applications, and recent advancements of these technologies are described in this review as an overview and delineation of the burgeoning ultrafast laser AM field. As they mature, their adoption by industry and incorporation into commercial systems will be facilitated by process advancements such as: process monitoring and control, increased throughput, and their integration into hybrid manufacturing systems. Recent progress regarding these aspects is also reviewed.
Dust Exposure and Respiratory Health among Selected Factories in Ethiopia: Existing Evidence, Current Gaps and Future Directions
Authors: Asgedom Akeza Awealom
Published: May 2023

Workers who are working in dusty environments might be associated with respiratory health problems. In Ethiopia, factories processing wood, textile, coffee, flour, cement and other materials are associated with dust emission. Furthermore, despite the adoption of the International Labor Organization (ILO) convention, the available constitution and labor proclamation, there are a lot of gaps in terms of occupational health and safety measures in Ethiopia. The current review aims to examine the existing evidence, current challenges and future direction regarding dust exposure and respiratory health in selected Ethiopian factories. Searches of peer-reviewed articles with full-length papers were made in online databases such as PubMed, Web of Science, MEDLINE, EMBASE and Google Scholar with a key words “Dust exposure”, “Respiratory health”, “Respiratory symptom”, “Ethiopia” and “Factory workers” from January 2000 to March 2023. The review found that excessive dust exposure is associated with a high prevalence of respiratory health problems. Lack of personal protective equipment and absence of safety and health training were the main occupational health deficits identified in most factories. Actions that focus on these deficiencies are commendable. Interventions focused on safety and health trainings, and the provision of adequate personal protective equipment of the required quality is recommended. In addition, administrative solutions and longitudinal studies on dust exposure and respiratory health are suggested.
Identification and Analysis of Territorial Spatial Utilization Conflicts in Yibin Based on Multidimensional Perspective
Authors: Meng Bao , Zhang Shaoyao , Deng Wei , Peng Li , Zhou Peng , Zhang Hao
Published: May 2023

The measurement of territorial spatial conflict degrees and the identification of conflict areas are important issues in the field of regional development planning. The scientific and comprehensive recognition and measurement of territorial spatial utilization conflicts, from a multidimensional perspective, are significant for the optimization of reasonable land use and the realization of sustainable spatial development in various regions. In this study, the territorial spatial development and utilization conflicts in Yibin were measured and analyzed in terms of the development intensity, landscape pattern index, and spatial suitability from a multidimensional perspective of the “upper limit-structure-bottom line” perspective of territorial spaces. Certain corresponding development strategies were proposed, and some major conclusions could be drawn: (1) In terms of the development intensity, the developable intensity value for most townships in Yibin is lower than the minimum developable intensity value, indicating their fine development potential in the future. However, the current development intensity of a few townships is higher than the maximum developable intensity value. These townships can be divided into topographic restricted zones, urban concentrated zones, and natural reserves. (2) In terms of landscape conflict, areas with mild, moderate, and severe conflict in the southern region of Yibin decreased significantly from 1990 to 2018, and severe conflict areas in the middle and northern regions decreased; however, moderate and mild conflict areas increased. Potential ecological conflict risks to the landscape cannot be ignored. (3) For spatial suitability, urban spatial conflict areas, agricultural spatial conflict areas, urban–ecological spatial conflict areas, and agricultural–ecological spatial conflict areas were recognized according to a comparison of the utilization status and suitability assessment results. (4) According to estimation results of three types of conflicts, townships in Yibin were divided into eight types of conflicts: (1) conflict caused by improper urban planning to squeeze ecological spaces and replace agricultural spaces; (2) conflict caused by extensive and disordered agricultural development; (3) conflict controlled by the squeezing of ecological spaces; (4) conflict controlled by the encroachment of ecological spaces; (5) conflict caused by backward urbanization; (6) conflict caused by low-level agricultural development; (7) conflict caused by overall development hysteresis; and (8) conflict caused by a shortage of development space. This study has some theoretical and practical implications for a comprehensive understanding of territorial spatial development patterns and their degrees, the scientific recognition and trade-off of multidimensional territorial spatial utilization conflicts, and realizing sustainable development in certain regions.
Impacts of Land Use and Land Cover Changes on Migration and Food Security of North Central Region, Nigeria
Authors: Okeleye Sunday Opeyemi , Okhimamhe Appollonia Aimiosino , Sanfo Safietou , Fürst Christine
Published: May 2023

Food security is adversely affected by challenges posed by changes in land use and land cover (LULC). LULC change impacts ecosystem functions and services, leading to migration of people, particularly rural dwellers. This paper uses multispectral satellite remote sensing, net migration data, household survey, stakeholders’ meetings, Focus Group Discussions (FGD), expert interviews and yields and estimated land mass of maize, rice, groundnut, cassava, and yam to assess the extent of LULC in Niger, Kwara, and Benue states of North Central Region of Nigeria and their relevance for migration and food security. Remote sensing data for 1990, 2000, 2013, and 2020 were extracted from Landsat imageries to obtain LULC change. Household survey was conducted to validate the data obtained from Landsat imageries. The results of LULC between 1990 and 2020 show that most of the vegetation, agricultural land, and water body areas in Kwara and Benue States have been converted to built-up areas and barren land, while an increase in agricultural land and built-up areas was observed in Niger State. Our household survey, stakeholders’ meetings, and interviews showed that there was a continuous massive migration of people, particularly young farmers, to cities leaving most of the existing agricultural lands uncultivated. This was due to the losses in agricultural land and conversion of some of the other LULC classes to barren land. We conclude that if this permanent migration remains uncontrolled, it will have significantly negative future impacts on food security of Nigeria. It is recommended that the government and its sub-ordinary administrative entities invest in more reliable infrastructure and attractive living environment for the rural dwellers to reduce the rate of rural-urban migration in the study areas.
In Silico Subtractive Proteomics and Molecular Docking Approaches for the Identification of Novel Inhibitors against Streptococcus pneumoniae Strain D39
Authors: Shami Ashwag , Alharbi Nada , Al-Saeed Fatimah , Alsaegh Aiman , Al Syaad Khalid , Abd El-Rahim Ibrahim , Mostafa Yasser , Ahmed Ahmed
Published: May 2023

Streptococcus pneumoniae is a notorious Gram-positive pathogen present asymptomatically in the nasophayrnx of humans. According to the World Health Organization (W.H.O), pneumococcus causes approximately one million deaths yearly. Antibiotic resistance in S. pneumoniae is raising considerable concern around the world. There is an immediate need to address the major issues that have arisen as a result of persistent infections caused by S. pneumoniae. In the present study, subtractive proteomics was used in which the entire proteome of the pathogen consisting of 1947 proteins is effectively decreased to a finite number of possible targets. Various kinds of bioinformatics tools and software were applied for the discovery of novel inhibitors. The CD-HIT analysis revealed 1887 non-redundant sequences from the entire proteome. These non-redundant proteins were submitted to the BLASTp against the human proteome and 1423 proteins were screened as non-homologous. Further, databases of essential genes (DEGG) and J browser identified almost 171 essential proteins. Moreover, non-homologous, essential proteins were subjected in KEGG Pathway Database which shortlisted six unique proteins. In addition, the subcellular localization of these unique proteins was checked and cytoplasmic proteins were chosen for the druggability analysis, which resulted in three proteins, namely DNA binding response regulator (SPD_1085), UDP-N-acetylmuramate—L-alanine Ligase (SPD_1349) and RNA polymerase sigma factor (SPD_0958), which can act as a promising potent drug candidate to limit the toxicity caused by S. pneumoniae. The 3D structures of these proteins were predicted by Swiss Model, utilizing the homology modeling approach. Later, molecular docking by PyRx software 0.8 version was used to screen a library of phytochemicals retrieved from PubChem and ZINC databases and already approved drugs from DrugBank database against novel druggable targets to check their binding affinity with receptor proteins. The top two molecules from each receptor protein were selected based on the binding affinity, RMSD value, and the highest conformation. Finally, the absorption, distribution, metabolism, excretion, and toxicity (ADMET) analyses were carried out by utilizing the SWISS ADME and Protox tools. This research supported the discovery of cost-effective drugs against S. pneumoniae. However, more in vivo/in vitro research should be conducted on these targets to investigate their pharmacological efficacy and their function as efficient inhibitors.
Anodal Transcranial Direct Current Stimulation over the Right Dorsolateral Prefrontal Cortex Boosts Decision Making and Functional Impulsivity in Female Sports Referees
Authors: Ghayebzadeh Shahrouz , Zardoshtian Shirin , Amiri Ehsan , Giboin Louis-Solal , Machado Daniel Gomes da Silva
Published: May 2023

We investigated the effect of anodal transcranial direct current stimulation (tDCS) over the right dorsolateral prefrontal cortex (rDLPFC) on the sensitive decision making of female team sports referees. Twenty-four female referees voluntarily participated in this randomized, double-blind, crossover, and sham-controlled study. In three different sessions, participants received either anodal (a-tDCS; anode (+) over F4, cathode (−) over the supraorbital region (SO)), cathodal (c-tDCS; −F4/+SO), or sham tDCS (sh-tDCS) in a randomized and counterbalanced order. a-tDCS and c-tDCS were applied with 2 mA for 20 min. In sh-tDCS, the current was turned off after 30 s. Before and after tDCS, participants performed the computerized Iowa Gambling Task (IGT) and Go/No Go impulsivity (IMP) tests. Only a-tDCS improved IGT and IMP scores from pre to post. The delta (Δ = post–pre) analysis showed a significantly higher ΔIGT in a-tDCS compared to c-tDCS (p = 0.02). The ΔIMP was also significantly higher in a-tDCS compared to sh-tDCS (p = 0.01). Finally, the reaction time decreased significantly more in a-tDCS (p = 0.02) and sh-tDCS (p = 0.03) than in c-tDCS. The results suggest that the a-tDCS improved factors related to sensitive decision making in female team sports referees. a-tDCS might be used as an ergogenic aid to enhance decision performance in female team sports referees.
Synthesis, Wear and Corrosion of Novel Electrospark and Electrospark–Electrochemical Hybrid Coatings Based on Carbon Steels
Authors: Benkovsky Iurii , Tsyntsaru Natalia , Silkin Serhii , Petrenko Vladimir , Pakstas Vidas , Cesiulis Henrikas , Dikusar Alexandr
Published: May 2023

The electrospark deposition (ESD) technique is a low-heat-input process that has great potential for coating applications and the restoration of damaged high-value parts. Carbon steels are commonly used as a substrate material for ESD coatings. However, we demonstrated that carbon steels could be used successfully as the electrode tool for the ESD process. Furthermore, ESD coatings commonly have a high as–deposited roughness. In view of this, in order to reduce the roughness of the ESD coatings, electrodeposition as a tool to alter surface morphology was investigated. Hence, the micro-leveling power of several electrolytes for Ni, Fe-W, Fe, and Cr electrodeposition were evaluated. The maximum leveling effect was detected for Ni electroplated from the Watts electrolyte. Thus, the novel hybrid coatings based on an ESD layer and a subsequent layer of electrodeposited Ni were obtained. ESD layers were obtained by using the following electrode tools as anodes: several types of carbon steels (St20, St30, and St45), alloys T15K6 (WC + TiC + Co), CuNiZn; and NiCr. The morphology and structure of the obtained hybrid coatings with an electrodeposited Ni top-layer was analyzed and compared to ESD coatings from the point of view of their wear and corrosion behavior. The wear rate of the novel ESD coatings based on carbon steels was comparable with coatings obtained using the NiCr electrode tool. Moreover, for all the studied cases, the corrosion resistance of the hybrid coatings was higher than for their ESD counterparts and close to electrolytic chromium.
Notes on the Transversality Method for Iterated Function Systems—A Survey
Authors: Solomyak Boris
Published: May 2023

This is a brief survey of selected results obtained using the “transversality method” developed for studying parametrized families of fractal sets and measures. We mostly focus on the early development of the theory, restricting ourselves to self-similar and self-conformal iterated function systems.
Analysis of the Prognostic and Immunological Role of HSPB1 in Pituitary Adenoma: A Potential Target for Therapy
Authors: Zhao Sida , Li Bin , Chen Yiyuan , Li Chuzhong , Zhang Yazhuo
Published: May 2023

Background and Objectives: The diagnosis and treatment of pituitary adenomas with cavernous sinus invasion pose significant challenges for clinicians. The objective of this study is to investigate the expression profile and prognostic value of HSPB1 (heat shock protein beta-1) in pituitary adenomas with invasive and non-invasive features. Additionally, we aim to explore the potential relationship between HSPB1 expression and immunological functions in pituitary adenoma. Materials and Methods: A total of 159 pituitary adenoma specimens (73 invasive tumours and 86 non-invasive tumours) underwent whole-transcriptome sequencing. Differentially expressed genes and pathways in invasive and non-invasive tumours were analysed. HSPB1 was subjected to adequate bioinformatics analysis using various databases such as TIMER, Xiantao and TISIDB. We investigated the correlation between HSPB1 expression and immune infiltration in cancers and predicted the target drug of HSPB1 using the TISIDB database. Results: HSPB1 expression was upregulated in invasive pituitary adenomas and affected immune cell infiltration. HSPB1 was significantly highly expressed in most tumours compared to normal tissues. High expression of HSPB1 was significantly associated with poorer overall survival. HSPB1 was involved in the regulation of the immune system in most cancers. The drugs DB11638, DB06094 and DB12695 could act as inhibitors of HSPB1. Conclusions: HSPB1 may serve as an important marker for invasive pituitary adenomas and promote tumour progression by modulating the immune system. Inhibitors of HSPB1 expression are currently available, making it a potential target for therapy in invasive pituitary adenoma.
A Simplified Kinetic Modeling of CO2 Absorption into Water and Monoethanolamine Solution in Hollow-Fiber Membrane Contactors
Authors: Tran Mai Lien , Nguyen Chi Hieu , Chu Kuan-Yan , Juang Ruey-Shin
Published: May 2023

The absorption of CO2 from CO2-N2 gas mixtures using water and monoethanolamine (MEA) solution in polypropylene (PP) hollow-fiber membrane contactors was experimentally and theoretically examined. Gas was flowed through the lumen of the module, whereas the absorbent liquid was passed counter-currently across the shell. Experiments were carried out under various gas- and liquid-phase velocities as well as MEA concentrations. The effect of pressure difference between the gas and liquid phases on the flux of CO2 absorption in the range of 15–85 kPa was also investigated. A simplified mass balance model that considers non-wetting mode as well as adopts the overall mass-transfer coefficient evaluated from absorption experiments was proposed to follow the present physical and chemical absorption processes. This simplified model allowed us to predict the effective length of the fiber for CO2 absorption, which is crucial in selecting and designing membrane contactors for this purpose. Finally, the significance of membrane wetting could be highlighted by this model while using high concentrations of MEA in the chemical absorption process.
High-Temperature Oxidation of Steel under Linear Flow Rates of Air and Water Vapor—An Experimental Determined Set of Data
Authors: Gaiser Georg , Presoly Peter , Bernhard Christian
Published: May 2023

High-temperature oxidation phenomena play a crucial role in steel production and processing. The development of new alloying concepts, the modification of production routes due to the decarbonization of steelmaking, and increasing quality demands will additionally stimulate research activities on high-temperature oxidation. Within the scope of this publication, the oxidation behavior of an unalloyed steel was investigated by means of thermogravimetric (TG) and metallographic analysis. The TG measurements were performed with a simultaneous thermal analyzer in combination with a water vapor generator and a mass spectrometer for quality control. Experiments were conducted in a temperature range from 900 to 1200 °C under various oxidation atmospheres, containing synthetic air and water vapor, with different linear flow rates of the oxidizing medium. According to the thermogravimetric data, an evaluation method is introduced to obtain direct kinetic data for linear and parabolic scale growth. The influence of the experimental parameters on high-temperature oxidation is discussed in detail.
Efficient Roll-Forming Simulation Using Non-Conformal Meshes with Hanging Nodes Handled by Lagrange Multipliers
Authors: Laruelle Cédric , Boman Romain , Papeleux Luc , Ponthot Jean-Philippe
Published: May 2023

Simulations of industrial roll-forming processes using the finite element method typically require an extremely fine discretization to obtain accurate results. Running those models using a classical finite element method usually leads to suboptimal meshes where some regions are unnecessarily over-refined. An alternative approach consists in creating non-conformal meshes where a number of nodes, called hanging nodes, do not match the nodes of adjacent elements. Such flexibility allows for more freedom in mesh refinement, which results in the creation of more efficient simulations. Consequently, the computational cost of the models is decreased with little to no impact on the accuracy of the results. Handling the generated hanging nodes can, however, be challenging. In this work, details are first given about the implementation of these particular meshes in an implicit finite element code with a special focus on the treatment of hanging nodes using Lagrange Multipliers. Standard and non-conformal meshes are then compared to experimental measurements on the forming of a U-channel. A more complex roll-forming simulation—a tubular rocker panel—is then showcased as proof of the potential of the method for industrial uses. Our main results show that the proposed method effectively reduces the computational cost of the roll-forming simulations with a negligible impact on their accuracy.
Selective Photooxidation of Valencene and Thymol with Nano-TiO2 and O2 as Oxidant
Authors: Martínez Henry , Neira Jane , Amaya Álvaro A. , Páez-Mozo Edgar A. , Martínez Ortega Fernando
Published: May 2023

The selective photocatalytic oxidation with O2 as oxidant of valencene and thymol was evaluated using nanostructured TiO2 under UV-Vis radiation at atmospheric conditions. The effect of the morphology and optical properties of TiO2 nanotubes and aminate nanoparticles was studied. Different scavengers were used to detect the presence of positive holes (h+), electrons (e−), hydroxyl radicals (•OH), and the superoxide radical anion (O2−) during the photooxidation reaction. Superoxide anion radical is the main oxidizing specie formed, which is responsible for the selective formation of nootkatone and thymoquinone using aminated TiO2 nanoparticles under 400 nm radiation.
Mechanochemical Synthesis and Molecular Docking Studies of New Azines Bearing Indole as Anticancer Agents
Authors: Ibrahim Mohamed , Farag Basant , Al-Humaidi Jehan , Zaki Magdi , Fathalla Maher , Gomha Sobhi
Published: May 2023

The development of new approaches for the synthesis of new bioactive heterocyclic derivatives is of the utmost importance for pharmaceutical industry. In this regard, the present study reports the green synthesis of new benzaldazine and ketazine derivatives via the condensation of various carbonyl compounds (aldehydes and ketones with the 3-(1-hydrazineylideneethyl)-1H-indole using the grinding method with one drop of acetic acid). Various spectroscopic techniques were used to identify the structures of the synthesized derivatives. Furthermore, the anticancer activities of the reported azine derivatives were evaluated against colon, hepatocellular, and breast carcinoma cell lines using the MTT technique with doxorubicin as a reference medication. The findings suggested that the synthesized derivatives exhibited potential anti-tumor activities toward different cell lines. For example, 3c, 3d, 3h, 9, and 13 exhibited interesting activity with an IC50 value of 4.27–8.15 µM towards the HCT-116 cell line as compared to doxorubicin (IC50 = 5.23 ± 0.29 µM). In addition, 3c, 3d, 3h, 9, 11, and 13 showed excellent cytotoxic activities (IC50 = 4.09–9.05 µM) towards the HePG-2 cell line compared to doxorubicin (IC50 = 4.50 ± 0.20 µM), and 3d, 3h, 9, and 13 demonstrated high potency (IC50 = 6.19–8.39 µM) towards the breast cell line (MCF-7) as compared to the reference drug (IC50 = 4.17 ± 0.20 µM). The molecular interactions between derivatives 3a-h, 7, 9, 11, 13, and the CDK-5 enzyme (PDB ID: 3IG7) were studied further using molecular docking indicating a high level of support for the experimental results. Furthermore, the drug-likeness analysis of the reported derivatives indicated that derivative 9 (binding affinity = −8.34 kcal/mol) would have a better pharmacokinetics, drug-likeness, and oral bioavailability as compared to doxorubicin (−7.04 kcal/mol). These results along with the structure–activity relationship (SAR) of the reported derivatives will pave the way for the design of additional azines bearing indole with potential anticancer activities.
The Antileishmanial Activity of Eugenol Associated with Lipid Storage Reduction Rather Than Membrane Properties Alterations
Authors: Hughes Kristelle , Le Thanh Binh , Van Der Smissen Patrick , Tyteca Donatienne , Mingeot-Leclercq Marie-Paule , Quetin-Leclercq Joëlle
Published: May 2023

Leishmaniasis is a neglected tropical disease that still infects thousands of people per year throughout the world. The occurrence of resistance against major treatments for this disease causes a healthcare burden in low-income countries. Eugenol is a phenylpropanoid that has shown in vitro antileishmanial activity against Leishmania mexicana mexicana (Lmm) promastigotes with an IC50 of 2.72 µg/mL and a high selectivity index. Its specific mechanism of action has yet to be studied. We prepared large unilamellar vesicles (LUVs), mimicking Lmm membranes, and observed that eugenol induced an increase in membrane permeability and a decrease in membrane fluidity at concentrations much higher than IC50. The effect of eugenol was similar to the current therapeutic antibiotic, amphotericin B, although the latter was effective at lower concentrations than eugenol. However, unlike amphotericin B, eugenol also affected the permeability of LUVs without sterol. Its effect on the membrane fluidity of Lmm showed that at high concentrations (≥22.5× IC50), eugenol increased membrane fluidity by 20–30%, while no effect was observed at lower concentrations. Furthermore, at concentrations below 10× IC50, a decrease in metabolic activity associated with the maintenance of membrane integrity revealed a leishmaniostatic effect after 24 h of incubation with Lmm promastigotes. While acidocalcisomes distribution and abundance revealed by Trypanosoma brucei vacuolar H+ pyrophosphatase (TbVP1) immunolabeling was not modified by eugenol, a dose-dependent decrease of lipid droplets assessed by the Nile Red assay was observed. We hereby demonstrate that the antileishmanial activity of eugenol might not directly involve plasma membrane sterols such as ergosterol, but rather target the lipid storage of Lmm.