bluuebunny/crossref_metadata_2025 huggingface dataset:
Chinesization of the quality of life assessment, venous device-port, and its reliability and validity tests for patients with breast cancer
Authors: Liu Ye , Xu Lei , Jiang Min , Chen Bo , Jing Liwei , Zhang Lei , Su Peng , Jin Feng , Mao Xiaoyun
Published: May 2020

Objective:

To translate the assessment item sets of the Canadian version of the quality of life assessment, venous device-port for breast cancer patients with chest and arm ports (i.e. different implanting sites) into Chinese version, and to conduct a test of reliability and validity for it.

Methods:

According to the Brislin translation model, quality of life assessment, venous device-port underwent literal and back translations, and the Chinese version of quality of life assessment, venous device-port was preliminarily revised by consulting an expert and a preliminary test. A total of 270 cancer patients undergoing chemotherapy were assessed during the use of ports, and the reliability and the validity of the Chinese version of quality of life assessment, venous device-port scale were then tested.

Results:

The scale consisted of 23 yes/no items and seven numerical rating scales. The total Cronbach’s α coefficient of the scale was 0.829, and each item ranged from 0.812 to 0.845. The item-level content validity index was 0.67–1.00, and the scale-level content validity index/average and the scale-level content validity index/universal agreement were 0.98 and 0.90, respectively. The correlation coefficient of the repeated measurement results of the scale was 0.554 ( p < 0.01). Exploratory factor analysis showed that the cumulative explained variance of five common factors was 64.197%.

Conclusion:

The Chinese version of quality of life assessment, venous device-port scale is an effective assessment tool for quality of life with good reliability and validity in breast cancer patients with different implantation sites for totally implanted venous access devices in northern China.
Novel phenylboronic acid derivatives containing phosphorous and nitrogen as lubricant additives: Synthesis, characterization, and tribological behaviors
Authors: Wang Lixia , Han Weifang , Ge Chunhua , Zhang Rui , Bai Yufeng , Zhang Xiangdong
Published: May 2020

Three phenylboronic acid derivatives containing phosphorous and nitrogen with chlorine (BNP1), methyl (BNP2), and nitro (BNP3) were successfully prepared and applied to evaluate the tribological behaviors as additives in liquid paraffin. Three derivatives exhibited high thermal stability. The tribological tests indicated that three derivatives lead to a substantial improvement in anti-friction and anti-wear properties of liquid paraffin. In comparison to BNP1 and BNP3, BNP2 performs best on friction-reducing and wear resistance performances. This is caused by the strong electron-donating ability of the methyl group in BNP2. The analysis of worn surfaces demonstrated that three derivatives could form a protective tribofilm containing boron, nitrogen, and phosphorus elements on the rubbing surfaces. Thus, three phenylboronic acid derivatives could be potential lubricant additives in industrial applications.
The numinous experience in the context of psychopathology and traumatic stress studies
Authors: Lönneker Christian , Maercker Andreas
Published: May 2020

The psychological phenomenon of a suddenly appearing, extremely enigmatic, and at the same time fascinating state in which one feels influenced by higher powers was described as a “numinous experience” by R. Otto and C. G. Jung. This condition is one of those subjectively non-rational experiences that have so far received little attention in cultural clinical psychology and yet have great potency to explain psychopathological phenomena. In the first section of this paper, we work towards a contemporary psychological definition both by focusing on the roles of paradoxical cognitions and dissociation and by presenting various differentiations and possible explanatory mechanisms. In the second part of this paper, we describe the numinous state as it occurs in selected clinical phenomena such as the subjective experience of potentially traumatic events including near-death experiences, sexual abuse of children, post-traumatic stress disorder, severe states of mourning (diagnosed today as prolonged grief disorder), and sleep paralysis. This paper is intended as a theoretical proposal aimed at better understanding subjectively non-rational states in patients.
Performance of capillary ceiling cooling panel on ceiling surface temperature and indoor thermal environment
Authors: Xie Dong , Wang Chenhua , Yu Chuck Wah , Wang Yun , Wang Hanqing
Published: May 2020

A new experimental methodology is presented to show the effect of water supply temperature, mass flow rate and thermal load distribution on the radiant ceiling capacity and thermal comfort conditions. Computerized fluid dynamics simulated vertical temperatures and velocities profiles were validated by a comparison with experimental results and the difference was within 10%. Uniform surface temperature distribution was achieved in a 45.6 m3 test room installed with capillary ceiling radiant cooling panels by an increase in water temperature and air supply velocity. When the ventilation system was turned off, the mean ceiling surface temperature rose from 16.9 ± 0.4°C to 21.5 ± 0.3°C with a rise in the inlet water temperature to 20.1°C. The temperature difference between the head and ankle of an occupant was 2.0°C, which complies with the Chinese standard, GB/T 18049-2017. At a height of 1–1.5 m, the maximum temperature fluctuation was 2°C in the horizontal direction. When the ventilation system was turned on, with the air supply temperature and velocity at 19.8°C and 1.11 m s−1, the ceiling surface temperature was increased by 0.5°C. The indoor air temperature has a positive correlation with the air supply temperature and internal heat load but a negative correlation with air supply velocity.
Dissimilar friction stir lap welding of aluminum to brass: Modeling of material mixing using coupled Eulerian–Lagrangian method with experimental verifications
Authors: Akbari Mostafa , Asadi Parviz
Published: May 2020

The intermetallic compounds formation and inter-material mixing have a critical impact on achieving a sound joint with fine mechanical properties in the case of dissimilar metal friction stir welding. In this investigation formation of intermetallic compounds as well as material flow that results in inter-material mixing during friction stir lap welding of aluminum and brass are studied. First, the 2.5-mm-thick aluminum sheet was laid on the same-thickness brass sheet and then, friction stir lap welding was applied using a tool with 4-mm pin length and 6-mm pin diameter. Next, experimental investigations were performed using scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, microhardness, and tensile shear test to probe the chemical compositions and intermetallic formation in the stir zone. Moreover, the coupled Eulerian–Lagrangian method is employed to simulate the stir zone formation during the process to further study inter-material mixing. In this method, the workpiece is modeled using Eulerian formulation, while Lagrangian formulation is utilized to model the tool. The model successfully predicts the stir zone formation and inter-material mixing in the aluminum–brass interface. Results shows that by increasing tool rotational speed from 500 to 2000 r/min the amount of inter material mixing significantly increases. Therefore, to achieve a joint with the highest strength in friction stir lap welding of aluminum–brass, the rotational speed should be lowered as much as it can produce defect-free joint.
From cartonera publishing practices to trans-formal methods for qualitative research
Authors: Bell Lucy , Flynn Alex , O’Hare Patrick
Published: May 2020

Interdisciplinarity, multidisciplinarity and counter-disciplinarity are the hallmark of cultural studies and qualitative research, as scholars over the past three decades have discussed through extensive self-reflexive inquiry into their own unstable and ever-shifting methods (Denzin and Lincoln, 2018; Dicks et al., 2006: 78; Grossberg, 2010). Building on the interdisciplinary thought of Jacques Rancière and Caroline Levine on the one hand and traditions of participatory action research and activist anthropology on the other, we bring the methods conversation forward by shifting the focus from disciplines to forms and by making a case for aesthetic practice as qualitative research process. In this paper, the question of methods is approached through the action-based Cartonera Publishing Project with editoriales cartoneras in Latin America – community publishers who make low-cost books out of materials recovered from the street in the attempt to democratise and decolonise literary/artistic production – and specifically through our process-oriented, collaborative work with four cartonera publishers in Brazil and Mexico. Guided by the multiple forms of cartonera knowledge production, which are rooted not in academic research but rather in aesthetic practice and community relations, we offer an innovative ‘trans-formal’ methodological framework, which opens up new pathways for practitioners and researchers to work, think and act across social, cultural and aesthetic forms.
Accurate Noninvasive Arterial Assessment of the Wounded Lower Limb: A Clinical Challenge for Wound Practitioners
Authors: Tehan Peta Ellen , Barwick Alex Louise , Casey Sarah Louise , Lanting Sean Michael , Chuter Vivienne Helaine
Published: May 2020

Arterial investigations are an essential part of lower extremity wound assessment. The results of these investigations assist the wound clinician to determine the etiology of the wound, predict healing capacity, and inform further management. There are a number of noninvasive testing methods available to practitioners, all with varying levels of reliability and accuracy. Clinical wound assessment guidelines give varied recommendations when it comes to lower limb vascular assessment in the presence of a wound. This leaves clinicians with little guidance on how to choose the most appropriate test, and uncertainty remains about which tests provide the most accurate information in different patient-specific contexts. Conditions such as advanced age, diabetes, and renal disease are known to affect the accuracy of some commonly used lower limb arterial assessment methods, and alternate testing methods should be considered in these cases. This seminal review discusses the reliability and accuracy of lower limb vascular assessment methods used to guide lower limb arterial assessment in the presence of wounds.
Admission Time Deep Swab Specimens Compared With Surgical Bone Sampling in Hospitalized Individuals With Diabetic Foot Osteomyelitis and Soft Tissue Infection
Authors: Manas Ana Belen , Taori Surabhi , Ahluwalia Raju , Slim Hani , Manu C. , Rashid Hisham , Kavarthapu Venu , Edmonds Michael , Vas Prashanth R. J.
Published: May 2020

Whether deep swab cultures taken at admission reliably identify pathogens compared to surgical bone specimens in hospitalized individuals with diabetic foot osteomyelitis and soft tissue infection is unclear. Comparison of microbiological isolates between a deep wound swab (DWS) taken at the time of admission through the actively infected, discharging ulcer probing to the bone and the subsequent surgical bone sample (SBS) taken during surgical debridement was made. A total of 63 subjects (age 60.8 ± 13.5 years, 75% male, 80% Type 2 diabetes, HbA1C 8.9%±2.2%) were included. The proportion of Gram-positive (DWS 49% v SBS 52%) and Gram-negative (DWS 60% v SBS 60%) isolates was similar between the techniques. However, the overall concordance of isolates between the two techniques was only fair (κ=0.302). The best concordance was observed for Staphylococcus aureus (κ=0.571) and MRSA (κ=0.644). There was a correlation between number of isolates in SBS with prior antibiotic therapy of any duration (r= -0.358, p=0.005) and with the duration of ulceration (r=0.296, p=0.045); no clinical correlations were found for DWS. Prior antibiotic therapy (p=0.03) and duration of ulceration <8 weeks (p=0.025) were predictive of negative growth on SBS. In conclusion, we found only a fair concordance between deep wound swabs acquired at admission and surgical bone specimens in those presenting with a severe diabetic foot infection and features of osteomyelitis. Ensuring early surgical debridement of all infected tissue and obtaining bone specimens should be considered a clinical priority, which may also reduce the likelihood of negative growth on SBS.
I Am Not Alone: Expanding the Epistemological Framework for Supporting Marginalized Women’s Transformative Learning
Authors: Bridwell Sandra D.
Published: May 2020

Marginalized adults have limited access to learning experiences that prioritize reflection and discourse, both considered preconditions in the Mezirow-informed field of transformative learning (TL). Using narrative analysis of a staff focus group and participant interviews over a 1-year learning journey, this study shows how a literacy program in a women’s homeless shelter created conditions that supported TL for two marginalized women of color. Results show how program learning goals were attuned to issues of positionality for women marginalized by race, class, and gender and were consistent with Africentric womanist epistemological and axiological assumptions. Conditions that fostered connectedness among women in troubling contexts and contributed to qualitative change in ways of knowing included purposeful spaces dedicated to reflection, dialogue, and student-centered pedagogy. The findings have important implications for the theoretical grounding of policy and practice in support of marginalized women’s TL.
Path planning of lunar robot based on dynamic adaptive ant colony algorithm and obstacle avoidance
Authors: Zhu Shinan , Zhu Weiyi , Zhang Xueqin , Cao Tao
Published: May 2020

Path planning of lunar robots is the guarantee that lunar robots can complete tasks safely and accurately. Aiming at the shortest path and the least energy consumption, an adaptive potential field ant colony algorithm suitable for path planning of lunar robot is proposed to solve the problems of slow convergence speed and easy to fall into local optimum of ant colony algorithm. This algorithm combines the artificial potential field method with ant colony algorithm, introduces the inducement heuristic factor, and adjusts the state transition rule of the ant colony algorithm dynamically, so that the algorithm has higher global search ability and faster convergence speed. After getting the planned path, a dynamic obstacle avoidance strategy is designed according to the predictable and unpredictable obstacles. Especially a geometric method based on moving route is used to detect the unpredictable obstacles and realize the avoidance of dynamic obstacles. The experimental results show that the improved adaptive potential field ant colony algorithm has higher global search ability and faster convergence speed. The designed obstacle avoidance strategy can effectively judge whether there will be collision and take obstacle avoidance measures.
The U Shape of Happiness Across the Life Course: Expanding the Discussion
Authors: Galambos Nancy L. , Krahn Harvey J. , Johnson Matthew D. , Lachman Margie E.
Published: May 2020

The notion of a U shape in happiness—that well-being is highest for people in their 20s, decreases to its nadir in midlife, and then rises into old age—has captured the attention of the media, which often cite it as evidence for a midlife crisis. We argue that support for the purported U shape is not as robust and generalizable as is often assumed and present our case with the following arguments: (a) Cross-sectional studies are inadequate for drawing conclusions about within-person change in happiness across the life span; (b) cross-sectional evidence with respect to the ubiquity and robustness of the U shape in general levels of happiness and life satisfaction is mixed; (c) longitudinal support for the U shape in happiness and life satisfaction is also mixed; (d) longitudinal research on subjective indicators of well-being other than general levels of happiness and life satisfaction challenges the U shape; (e) when asked to reflect on their lives, older adults tend to recall midlife as one of the more positive periods; and (f) a focus on a single trajectory of well-being is of limited scientific and applied value because it obscures the diversity in pathways throughout life as well as its sources. Understanding happiness across the life course and moving the research field forward require a multidisciplinary, collaborative approach.
The Effects of Gender Trouble: An Integrative Theoretical Framework of the Perpetuation and Disruption of the Gender/Sex Binary
Authors: Morgenroth Thekla , Ryan Michelle K.
Published: May 2020

In the Western world, gender has traditionally been viewed as binary and as following directly from biological sex. This view is slowly changing among both experts and the general public, a change that has been met with strong opposition. In this article, we explore the psychological processes underlying these dynamics. Drawing on previous work on gender performativity as well as gender as a performance, we develop a psychological framework of the perpetuation and disruption of the gender/sex binary on a stage that facilitates and foregrounds binary gender/sex performance. Whenever character, costume, and script are not aligned the gender/sex binary is disrupted and gender trouble ensues. We integrate various strands of the psychological literature into this framework and explain the processes underlying these reactions. We propose that gender trouble can elicit threat—personal threat, group-based and identity threat, and system threat—which in turn leads to efforts to alleviate this threat through the reinforcement of the gender/sex binary. Our framework challenges the way psychologists have traditionally treated gender/sex in theory and empirical work and proposes new avenues and implications for future research.
Value creation analysis using atomic business models: The case of Digikala e-retailer – Part B
Authors: Hanafizadeh Payam , Mehri Saeedeh , Hasanabadi Hamid
Published: May 2020

One of the reasons most startups fail, despite their growing number, is the inability and lack of flexibility of their business models in responding to market changes. In addition, due to the uncertainty of the startups’ environment, it is difficult to gain competitive advantage; startups need to continuously change their business models. One of the most common electronic business models is the electronic retailer. Despite the many challenges facing e-retailers due to market changes and customer preferences, Digikala has been ranked as the most popular and most visited website and has managed to gain over 85% of the Iranian retail market share. The purpose of this study is to analyze the value creation in Digikala in order to answer the following questions: Through which atomic business model can business value be realized? What change strategies should be applied to be able to provide a unique and stable value and be successful?
Barista’s fracture: a new occupational hazard
Authors: Yusuf Baasil Syed , Segaren Neil , Segaren Nicholas , Di Mascio Livio
Published: May 2020

Lesson

Stress fracture of the clavicle is a rare injury usually occurring in high-level athletes. It is typically a result of repetitive sporting activity or unusual strain. We present the first case of an occupational clavicle stress fracture in a young female barista. The patient initially presented with insidious onset clavicular pain. There was no history of trauma, and an undisplaced fracture was present on the plain radiograph but overlooked by the emergency physicians. Two weeks later, the patient presented again with worsening symptoms, and a displaced fracture of the clavicle was diagnosed on plain radiograph. A thorough occupational history revealed the cause of her pain, which was the mechanical activity of coffee tamping and the fracture went on to unite with no further complications. No other cause was found on investigations including magnetic resonance imaging. The fracture healed with cessation of coffee tamping. This case highlights a previously unrecognised occupational hazard of coffee tamping as a potential cause of stress fracture of clavicle.
Downregulated MiR-206 expression promotes the proliferation and migration of macrophages by regulating IL-17A/REG3A pathway
Authors: Huang Xuan , Gong Fang , Lu Zhixian , Zhu Jie , Yu Qun
Published: May 2020

This study sought to investigate the role of miR-206 in polymyositis/dermatomyositis (PM/DM) development. Transwell and 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium inner salt (MTS) assay were performed to investigate cell migration and proliferation. Real-time polymerase chain reaction (PCR) analysis was used to determine the expression of miR-206, interleukin-17A (IL-17A), IL-17 receptor A (IL-17RA), and regenerating islet-derived protein 3-alpha (REG3A). Significantly, miR-206 mimics decreased macrophage migration and proliferation, while miR-206 inhibitors exhibited the opposite effects. Indeed, elevating IL-17RA levels resulted in increased REG3A expression, which was inhibited by IL-17RA siRNA. Besides, miR-206 mimics decreased IL-17A and REG3A expressions, but miR-206 inhibitors showed opposite effects. Moreover, miR-206 expression in PM/DM patients was significantly reduced compared with the healthy controls, while IL-17A and REG3A expressions substantially increased among PM/DM patients. These findings suggested that downregulation of miR-206 increased the migration and proliferation of macrophages via IL-17A/REG3A signaling pathway, which could promote the inflammatory infiltration in PM/DM.
The Impact of COVID-19 Pandemic on Spine Surgeons Worldwide
Authors: Louie Philip K. , Harada Garrett K. , McCarthy Michael H. , Germscheid Niccole , Cheung Jason P. Y. , Neva Marko H. , El-Sharkawi Mohammad , Valacco Marcelo , Sciubba Daniel M. , Chutkan Norman B. , An Howard S. , Samartzis Dino
Published: May 2020

Study Design:

Cross-sectional, international survey.

Objectives:

The current study addressed the multi-dimensional impact of COVID-19 upon healthcare professionals, particularly spine surgeons, worldwide. Secondly, it aimed to identify geographical variations and similarities.

Methods:

A multi-dimensional survey was distributed to surgeons worldwide. Questions were categorized into domains: demographics, COVID-19 observations, preparedness, personal impact, patient care, and future perceptions.

Results:

902 spine surgeons representing 7 global regions completed the survey. 36.8% reported co-morbidities. Of those that underwent viral testing, 15.8% tested positive for COVID-19, and testing likelihood was region-dependent; however, 7.2% would not disclose their infection to their patients. Family health concerns were greatest stressor globally (76.0%), with anxiety levels moderately high. Loss of income, clinical practice and current surgical management were region-dependent, whereby 50.4% indicated personal-protective-equipment were not adequate. 82.3% envisioned a change in their clinical practice as a result of COVID-19. More than 33% of clinical practice was via telemedicine. Research output and teaching/training impact was similar globally. 96.9% were interested in online medical education. 94.7% expressed a need for formal, international guidelines to manage COVID-19 patients.

Conclusions:

In this first, international study to assess the impact of COVID-19 on surgeons worldwide, we identified overall/regional variations and infection rate. The study raises awareness of the needs and challenges of surgeons that will serve as the foundation to establish interventions and guidelines to face future public health crises.
Atrial Arrhythmias in a Patient Presenting With Coronavirus Disease-2019 (COVID-19) Infection
Authors: Seecheran Rajeev , Narayansingh Roshni , Giddings Stanley , Rampaul Marlon , Furlonge Kurt , Abdool Kamille , Bhagwandass Neal , Seecheran Naveen Anand
Published: May 2020

The coronavirus disease-2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) that has significant potential cardiovascular implications for patients. These include myocarditis, acute coronary syndromes, cardiac arrhythmias, cardiomyopathies with heart failure and cardiogenic shock, and venous thromboembolic events. We describe a Caribbean-Black gentleman with COVID-19 infection presenting with atrial arrhythmias, namely, atrial flutter and atrial fibrillation, which resolved with rate and rhythm control strategies, and supportive care.
Against austerity and repression: Historical and contemporary manifestations of progressive politicisation in Turkey
Authors: Dönmez Pınar E
Published: May 2020

This paper aims to explore the growing and deepening trend of politics of repression coupled with prolonged crisis and austerity politics, reflecting on the potentials as well as limitations of progressive politics in such a constrained context. Austerity policies continue pushing for anti-labour and reactionary politics in a variety of forms reflecting the unresolved crisis conditions of contemporary capitalism. While the liberal democratic state-form remains relatively intact in particular contexts, in others, it gradually evolves into repressive forms. The growing repression risks conceiving the anti-authoritarian struggles and the anti-capitalist and labour movements separate and/or mutually exclusive. This review article draws on the recent insights of (de)politicization, labour geography and history and political economy scholarships with specific reference to the case of Turkey while cautioning against the binary thinking of ‘success’ and ‘failure’ in leftist and labour mobilisations. It proposes a historical perspective in order to appreciate the diversity and multiplicity of struggles against the intersecting nodes of austerity, capitalism and repression in the complex geographies of periphery.
Potential use of Kebilian clay reserves(southern Tunisia)for the production of geopolymer materials
Authors: Ounissi Chedlia , Mahmoudi Salah , Valentini Luca , Bennour Ali , Garbin Enrico , Artioli Gilberto , Montacer Mabrouk
Published: May 2020

The aim of this study was to help drive the Tunisian construction industry towards a more sustainable approach given the existence of abundant local raw material deposits that could be exploited for the production of low-CO2binders. Various clay sediments from the Kebili region (southern Tunisia) were characterized by chemical analysis, X-ray diffraction, thermal analysis and geotechnical tests to determine their suitability for the preparation of geopolymer binders. The clays consist of illite and kaolinite with other accessory minerals. To test the possibility of using these materials as precursors for the production of low-CO2and low-cost geopolymers, the raw samples were calcined and activated by addition of solid sodium silicate. Compressive strength tests performed on four alkali-activated clays show that promising mechanical performance may be achieved, with mechanical strength values as high as 25 MPa after 7 days, depending on the clay composition. The mechanical strength is related to the SiO2:Al2O3and Al2O3:(NaO2+ K2O) ratios. Careful selection of the raw materials is, therefore, an essential step in the exploitation of clay deposits to be used for the production of ecological materials such as geopolymers.
FVIII half-life extension by coadministration of a D′D3 albumin fusion protein in mice, rabbits, rats, and monkeys
Authors: Pestel Sabine , Beltz Hans-Wilhelm , Claar Philipp , Lind Holger , Mischnik Marcel , Raquet Elmar , Andrews Arna , Simmonds Jason , Tomasetig Vesna , Dower Steven K. , Tjärnlund-Wolf Anna , Schulte Stefan , Schmidt Peter M. , Weimer Thomas
Published: May 2020

A novel mechanism for extending the circulatory half-life of coagulation factor VIII (FVIII) has been established and evaluated preclinically. The FVIII binding domain of von Willebrand factor (D′D3) fused to human albumin (rD′D3-FP) dose dependently improved pharmacokinetics parameters of coadministered FVIII in all animal species tested, from mouse to cynomolgus monkey, after IV injection. At higher doses, the half-life of recombinant FVIII (rVIII-SingleChain) was calculated to be increased 2.6-fold to fivefold compared with rVIII-SingleChain administered alone in rats, rabbits, and cynomolgus monkeys, and it was increased 3.1-fold to 9.1-fold in mice. Sustained pharmacodynamics effects were observed (ie, activated partial thromboplastin time and thrombin generation measured ex vivo). No increased risk of thrombosis was observed with coadministration of rVIII-SingleChain and rD′D3-FP compared with rVIII-SingleChain alone. At concentrations beyond the anticipated therapeutic range, rD′D3-FP reduced the hemostatic efficacy of coadministered rVIII-SingleChain. This finding might be due to scavenging of activated FVIII by the excessive amount of rD′D3-FP which, in turn, might result in a reduced probability of the formation of the tenase complex. This observation underlines the importance of a fine-tuned balance between FVIII and its binding partner, von Willebrand factor, for hemostasis in general.
BK virus–specific T-cell immune reconstitution after allogeneic hematopoietic cell transplantation
Authors: Espada Eduardo , Cheng Matthew P. , Kim Haesook T. , Woolley Ann E. , Avigan Jason I. , Forcade Edouard , Soares Maria V. D. , Lacerda João F. , Nikiforow Sarah , Gooptu Mahasweta , Romee Rizwan , Alyea Edwin P. , Armand Philippe , Cutler Corey S. , Ho Vincent T. , Koreth John , Antin Joseph H. , Soiffer Robert J. , Marty Francisco M. , Ritz Jerome
Published: May 2020

Clinical disease caused by BK virus reactivation is a frequent complication of allogeneic hematopoietic cell transplantation (HCT). Because of the lack of effective antiviral agents, BK virus–specific T cells are emerging as a potential therapy for BK virus disease, but the immune response to BK virus after allogeneic HCT has not been well characterized. Our study describes reconstitution of BK virus–specific T-cell immunity in 77 adult patients after HCT. All patients had urinary symptoms, and urine was tested for BK virus replication; 33 patients were positive for BK virus (cases), and 44 were negative (controls). In BK virus cases, the median time to first positive test was 75 days (range, 2-511). BK virus cases had lower CD4 T-cell counts 3 to 9 months after transplant, but CD8 T-cell counts were similar in cases and controls. BK virus–specific T cells were identified by cytokine flow cytometry in cryopreserved samples collected prospectively. BK virus–specific CD4 T cells producing T helper 1 (Th1) cytokines recovered quickly after HCT. BK virus–specific T cells were detected more frequently in patients with BK virus reactivation at most time points, and CD4 T cells producing Th1 cytokines were more frequent than BK virus–specific cytolytic CD8 T cells. Early detection of interferon-γ+ and cytolytic BK virus–specific CD4 T cells was associated with lower rates of hematuria among cases. Overall, our study describes recovery of BK virus–specific T cells after HCT and the distinct roles for BK virus–specific T cells in the development and resolution of clinical symptoms.
Upregulation of miR-215 attenuates propofol-induced apoptosis and oxidative stress in developing neurons by targeting LATS2
Authors: Tang Fang , Zhao Lili , Yu Qi , Liu Tianyin , Gong Hongyan , Liu Zhiyi , Li Qing
Published: May 2020

Background

Propofol is an intravenous anesthetic agent that commonly induces significant neuroapoptosis. MicroRNAs (miRNAs) have been reported to participate in the regulation of propofol exposure-mediated neurotoxicity. MiR-215, as one of miRNAs, was found to regulate nerve cell survival. However, the mechanism through which miRNAs regulate propofol exposure-mediated neurotoxicity is still unclear.

Methods

Real-time PCR was used to detect miR-215 expression level. Cell viability was measured using MTT assay. Cell apoptosis was examined via flow cytometry analysis. ROS, MDA, LDH and SOD levels were assayed through ELISA kits. Dual luciferase reporter assay identified the interaction between miR-215 and large tumor suppressor 2 (LATS2). Protein level was detected using western blot analysis.

Results

MiR-215 expression was downregulated in propofol-treated rat hippocampal neurons. MiR-215 mimics promoted cell viability and reduced apoptosis in propofol-treated neonatal rat hippocampal neuron. MiR-215 mimics also caused inhibition of oxidative stress as evidenced by suppression of ROS, MDA and LDH levels as well as increase of SOD level. In addition, we found that large tumor suppressor 2 (LATS2) is a target of miR-215 and miR-215 mimics decreased LATS2 level in propofol-treated neonatal rat hippocampal neuron. Further, LATS2 overexpression suppressed the effect of miR-215 on propofol-induced apoptosis and oxidative stress in neonatal rat hippocampal neuron.

Conclusion

Taken together, we demonstrate that miR-215 attenuates propofol-induced apoptosis and oxidative stress in neonatal rat hippocampal neuron by targeting LATS2, suggesting that miR-215 may provide a new candidate for the treatment of propofol exposure-induced neurotoxicity.
Predictors of pain in general ageing populations: results from a multi-country analysis based on ATHLOS harmonized database
Authors: Raggi Alberto , Leonardi Matilde , Mellor-Marsá Blanca , Moneta Maria V. , Sanchez-Niubo Albert , Tyrovolas Stefanos , Giné-Vázquez Iago , Haro Josep M. , Chatterji Somnath , Bobak Martin , Ayuso-Mateos Jose L. , Arndt Holger , Hossin Muhammad Z. , Bickenbach Jerome , Koskinen Seppo , Tobiasz-Adamczyk Beata , Panagiotakos Demosthenes , Corso Barbara
Published: May 2020

Background

Pain is a common symptom, often associated with neurological and musculoskeletal conditions, and experienced especially by females and by older people, and with increasing trends in general populations. Different risk factors for pain have been identified, but generally from studies with limited samples and a limited number of candidate predictors. The aim of this study is to evaluate the predictors of pain from a large set of variables and respondents.

Methods

We used part of the harmonized dataset of ATHLOS project, selecting studies and waves with a longitudinal course, and in which pain was absent at baseline and with no missing at follow-up. Predictors were selected based on missing distribution and univariable association with pain, and were selected from the following domains: Socio-demographic and economic characteristics, Lifestyle and health behaviours, Health status and functional limitations, Diseases, Physical measures, Cognition, personality and other psychological measures, and Social environment. Hierarchical logistic regression models were then applied to identify significant predictors.

Results

A total of 13,545 subjects were included of whom 5348 (39.5%) developed pain between baseline and the average 5.2 years’ follow-up. Baseline risk factors for pain were female gender (OR 1.34), engaging in vigorous exercise (OR 2.51), being obese (OR 1.36) and suffering from the loss of a close person (OR 1.88) whereas follow-up risk factors were low energy levels/fatigue (1.93), difficulties with walking (1.69), self-rated health referred as poor (OR 2.20) or average to moderate (OR 1.57) and presence of sleep problems (1.80).

Conclusions

Our results showed that 39.5% of respondents developed pain over a five-year follow-up period, that there are proximal and distal risk factors for pain, and that part of them are directly modifiable. Actions aimed at improving sleep, reducing weight among obese people and treating fatigue would positively impact on pain onset, and avoiding vigorous exercise should be advised to people aged 60 or over, in particular if female or obese.
Localized biphasic malignant mesothelioma presenting as a giant pelvic wall mass: a rare case report and literature review
Authors: Liu Yunsong , Wu Jingjun , Zhao Ying , Zhang Pengxin , Hua Zhengyu , Dong Wan , Lin Tao , Liu Ailian
Published: May 2020

Background

Localized biphasic MPeM is rare in clinical practice, we reviewed 8 cases of localized biphasic MPeM (including our present case), and summarized the clinical and imaging features of the disease.

Case presentation

We reported a 79-year-old man with chief complaint of a narrowing in the caliber of the stool for one year. A soft tissue shadow was occasionally found by CT examination in the right pelvic wall, and it was diagnosed as localized biphasic malignant peritoneal mesothelioma (MPeM) by postoperative pathology. Radical excision was performed and no radio-chemotherapy was applied. Nearly six years after surgery, the mass was significantly enlarged, and the neighboring tissues including rectum, prostate, seminal vesicle, and right ischial ramus were all infiltrated. The patient was in the end stage of cancer with poor prognosis.

Conclusions

The localized biphasic MPeM may show following characteristics: (1) with heterogeneous low-density and obscure margin; (2) with low incidence rate of ascites; (3) with few central hemorrhage and necrosis; (4) with few calcified structures; (5) with mild to moderate heterogeneous delayed enhancement on contrast-enhanced CT. The imaging characteristics can provide further information for the diagnosis of localized biphasic MPeM in the future.
Stability of the gross motor function classification system in children with cerebral palsy for two years
Authors: Park Eun-Young
Published: May 2020

Background

The prognosis of gross motor function is a major concern for therapy and intervention in children with cerebral palsy (CP). The classification system for gross motor function, the Gross Motor Function Classification System (GMFCS), is actively studied because it could be useful in the communication between professionals and families. This study aimed to verify the stability of GMFCS over 2 years in children with CP aged 2–12 years.

Methods

The GMFCS level of 100 children with CP who underwent rehabilitation therapy in hospitals or who attended special elementary schools in South Korea were collected in the study. The agreements across three measurement points were analyzed in these children.

Results

The weighted kappa coefficients were statistically significant (p < .05). The coefficients ranged from 0.690 to 0.789 in children with CP aged 2–12 years. The lowest coefficient of 0.557 was observed in children with CP aged 2–4 years between the first and third measurements points.

Conclusions

The results provided evidence of GMFCS stability for the first year and change of the GMFCS during the two-year study period in children aged 2–4 years. Moreover, the findings indicate that the stability of GMFCS varies with time, duration, and age. It is recommended that GMFCS assessments be performed periodically, which are even more necessary for children with CP aged 2–4 years.
Visual rehabilitation of patients with corneal diseases
Authors: Oeverhaus Michael , Dekowski Dirk , Hirche Herbert , Esser Joachim , Schaperdoth-Gerlings Barbara , Eckstein Anja
Published: May 2020

Background

Although most patients with visual impairment due to corneal diseases can be treated successfully with surgery, some require visual rehabilitation to restore reading ability. To evaluate the best LVAs especially in terms of reading speed and characterize this specific patient group we performed a prospective, randomized cross-over trial.

Methods

All 34 patients underwent a detailed examination (slit-lamp, funduscopy, SD-OCT, ETDRS) as screening. Only patients with corneal diseases without other ocular diseases were included. Reading-speed was assessed with International-Reading-Speed-Texts (IReST) consecutively with five different LVAs (low vision aids) during one day in a randomized cross-over design. Corneal haze was quantified with corneal densitometry (Pentacam).

Results

Patients were either visually impaired (n = 28), severely impaired (n = 4) or legally blind (n = 2). Patients read significantly faster with LVAs (p < 0.0001). Fastest reading speed could be achieved with video magnifier (CCTV). Optical magnifier and portable-electronic magnifier enabled significantly lower reading speeds (p < 0.01). In a subgroup of patients (VA < 3/60,n = 6) black background enabled patients to read significantly faster compared to white background (p = 0.03).

Conclusion

Patients with low magnification requirement can be treated successfully with optical LVAs and portable-electronic magnifiers. More severely afflicted patients need a CCTV. Black background enables fastest reading-speeds, probably due to less blinding. Visual impairment can be estimated with corneal densitometry. Our trial confirms the capability of LVAs to successfully restore the reading ability in patients with corneal diseases, which is a crucial part of visual rehabilitation.

Trial registration

This trial was registered at the German Clinical Trials Register as DRKS00010887 at 09.08.2016.
Higher prevalence of obesity among children with functional abdominal pain disorders
Authors: Galai Tut , Moran-Lev Hadar , Cohen Shlomi , Ben-Tov Amir , Levy Dina , Weintraub Yael , Amir Achiya , Segev Or , Yerushalmy-Feler Anat
Published: May 2020

Background

Functional abdominal pain (FAP) disorders are one of the most common gastrointestinal disorders in children. We aimed to define the association between obesity and functional abdominal pain (FAP) disorders and to assess differences between overweight/obese children and normal weight children with FAP disorders.

Methods

We conducted a retrospective study of children (2–18 years old) with a clinical diagnosis of FAP who were followed-up in our pediatric gastroenterology unit between 1/2016–10/2018. FAP disorders were defined according to the ROME IV criteria. Body mass index (BMI) percentiles were defined by CDC standards. Patients with BMIs ≥85th percentile were designated as being overweight/obese. A population control group was obtained from the 2015–2016 Israel national health survey.

Results

Data from 173 children with FAP disorders (median age 11.5 years, 114 females) were included. Seventy-one children (41%) were classified as having functional abdominal pain-NOS, 67 (38.7%) as having irritable bowel syndrome (IBS), and 35 (20.2%) has having functional dyspepsia. Fifty-three children (30.6%) were classified as being overweight/obese.

Adolescents with FAP disorders had a significantly higher prevalence of overweight/obesity compared to controls (39.5% vs. 30%, respectively, p = 0.04). Children with FAP and overweight were older [12.4 (range 9.8–15.3) vs. 10.8 (7.4–14.1) years, p = 0.04] and had more hospitalizations due to FAP (20.8% vs. 7.6%, p = 0.01) compared to Children with FAP and normal weight.

Conclusions

Adolescents with FAP had higher prevalence of overweight/obesity compared to controls. Future studies are warranted to raise awareness of weight issues in FAP and determine the effect of weight loss on FAP.
Promoting parent-child relationships and preventing violence via home-visiting: a pre-post cluster randomised trial among Rwandan families linked to social protection programmes
Authors: Betancourt Theresa S. , Jensen Sarah K. G. , Barnhart Dale A. , Brennan Robert T. , Murray Shauna M. , Yousafzai Aisha K. , Farrar Jordan , Godfroid Kalisa , Bazubagira Stephanie M. , Rawlings Laura B. , Wilson Briana , Sezibera Vincent , Kamurase Alex
Published: May 2020

Background

Sugira Muryango is a father-engaged early child development and violence-prevention home-visiting programme delivered by trained lay workers. This cluster-randomised trial evaluates whether families living in extreme poverty (Ubudehe 1, the poorest category in the Government of Rwanda’s wealth ranking) who receive Sugira Muryango in combination with a government-provided social protection programme demonstrate greater responsive, positive caregiving, nutrition, care seeking, hygiene, and father involvement compared with control families receiving usual care (UC).

Methods

Using detailed maps, we grouped closely spaced villages into 284 geographic clusters stratified by the type of social protection programmes operating in the village clusters; 198 clusters met all enrolment criteria. Sugira Muryango was delivered to n = 541 families in 100 treatment clusters with children aged 6–36 months living in extreme poverty. We assessed changes in outcomes in intervention and n = 508 UC control families using structured surveys and observation. Analyses were intent to treat using mixed models to accommodate clustering.

Results

Families receiving Sugira Muryango improved on core outcomes of parent-child relationships assessed using the Home Observation for Measurement of the Environment (Cohen’s d = 0.87, 95% CI: 0.74, 0.99) and the Observation of Mother-Child Interaction (Cohen’s d = 0.29, 95% CI: 0.17, 0.41). We also saw reductions in harsh discipline on items from the UNICEF MICS (OR = 0.30: 95% CI: 0.19, 0.47) and in violent victimisation of female caregivers by their partners (OR = 0.49, 95% CI: 0.24, 1.00) compared with UC. Moreover, children in families receiving SM had a 0.45 higher increase in food groups consumed in the past 24 h (Cohen’s d = 0.35, 95% CI: 0.22, 0.47), increased care seeking for diarrhoea (OR = 4.43, 95% CI: 1.95, 10.10) and fever (OR = 3.28, 95% CI: 1.82, 5.89), and improved hygiene behaviours such as proper treatment of water (OR = 3.39, 95% CI: 2.16, 5.30) compared with UC. Finally, Sugira Muryango was associated with decreased caregiver depression and anxiety (OR = 0.58, 95% CI: 0.38, 0.88).

Conclusions

Sugira Muryango led to improvements in caregiver behaviours linked to child development and health as well as reductions in violence.

Trial registration

ClinicalTrials.gov number NCT02510313.
The predictive value of procalcitonin for postoperative early pancreatic fistula
Authors: Zhou Quanyu , Xia Yuxiao , Lei Zehua
Published: May 2020

Background

To investigate the early prediction value of procalcitonin (PCT) in pancreatic fistula (POPF) after pancreatoduodenectomy (PD).

Method

Retrospective analysis of clinical data of 67 patients undergoing pancreaticoduodenectomy (PD) and 19 patients undergoing distalpancreatectomy (DP) were performed in the Department of Hepatobiliary Surgery, Leshan People’s Hospital from January 2017 to December 2018. All patients were divided into POPF group and non-POPF group depending on the presence of pancreatic fistula. And fistulas were classified according to the ISGPF classification scheme. Plasma PCT levels, serum CRP concentration, and WBC counts were assessed preoperatively and on postoperative days (PODs) 1, 3, and 5. Statistical analyses were performed with statistical software. The ROC curve was used to analyze the efficacy of PCT and CRP in POPF prediction after surgery and determine their Cut-off value.

Result

There were no statistically significant differences identified in age, gender, BMI, diabetes, abdominal surgery history, preoperative laboratory data, operation time, intraoperative bleeding volume, tumor nature and medical expenses of PD patients between the two groups (P > 0.05). While the incidence of postoperative hyperglycemia, postoperative ICU rate and postoperative hospital stay were statistically significant (P < 0.05). The AUC for PCT diagnosis of pancreatic fistula 1 day after surgery was 0.77 (95% CI: 0.675 ~ 0.860). Compared with CRP [0.53 (95% CI: 0.420 ~ 0.639)] and WBC [0.60 (95% CI: 0.490 ~ 0.705)], the optimal cut-off value (cut-off) was 0.67 μg/L. At this time, the sensitivity and specificity of detecting pancreatic fistula were 73.68 and 76.12%, respectively. The results at 3 days after surgery were similar to those at 5 days after surgery. And DP patients had similar results as PD patients.

Conclusion

The PCT is valuable for early prediction of pancreatic fistula after Pancreaticoduodenectomy.