bluuebunny/crossref_metadata_2025 huggingface dataset:
Paralisia facial bilateral e leucemia mielóide aguda: uma associação pouco comum
Authors: Pereira Marta Sofia , Faria Frederica , Menezes Falcão Luiz
Published: October 2022

A leucemia mielóide aguda (LMA) é uma doença maligna do tecido hematopoiético. A apresentação da doença pode estar relacionada com a perda de função da medula óssea ou com sintomas gerais das doenças neoplásicas. O envolvimento extra-medular é responsável por formas de apresentação menos frequentes que podem dificultar um diagnóstico precoce. A hipertrofia gengival não é incomum na LMA mas os casos de paralisia facial bilateral são raros. Neste artigo os autores apresentam o caso de um homem de 70 anos que surge com hipertrofia gengival que inicialmente não é valorizada e que desenvolve, após três semanas, uma paralisia facial periférica bilateral. O mielograma revelou uma LMA. Com a quimioterapia dirigida o doente entrou em remissão completa mas manteve a sintomatologia de apresentação da doença.
Crescimento e puberdade na diabetes mellitus tipo 1 – experiência de uma unidade de endocrinologia pediátrica
Authors: Timóteo Catarina , Castanhinha Susana , Constant Carolina , Robalo Brígida , Pereira Carla , Sampaio Lurdes
Published: October 2022

Introdução: a Diabetes Mellitus tipo 1 (DM1) é a doença crónica endócrino-metabólica mais frequente em idade pediátrica. Associa-se a complicações vasculares e neuropáticas, podendo afectar também o crescimento e desenvolvimento. Objectivo: relacionar o controlo metabólico e duração da doença com o crescimento e puberdade em jovens com DM1 seguidos em consulta de Endocrinologia Pediátrica de um Hospital Central. Material e métodos: estudo retrospectivo analítico. Amostra obtida a partir dos doentes com DM1 seguidos na Unidade de Endocrinologia Pediátrica do Hospital de Santa Maria (HSM) (Lisboa, Portugal) desde 1994 até Março de 2011. Critérios de inclusão: doentes diagnosticados antes do início da puberdade e com atingimento da estatura final durante o período de seguimento. Variáveis estudadas: sexo; idade, peso e estatura ao diagnóstico e final; estatura dos pais; velocidade de crescimento; ganho estatural pubertário; idade da menarca e controlo metabólico durante a puberdade. Resultados: 39 doentes, 51% sexo feminino, 82% com diagnóstico há menos de 5 anos quando iniciou a puberdade. Cinquenta e quatro por cento apresentou, durante a puberdade, HbA1c média entre 8-10%, que se considerou razoável. Parece haver uma tendência para uma associação inversa entre a HbA1c e a velocidade de crescimento máxima e o ganho estatural pubertário, embora sem significado estatístico. Constatadas estaturas superiores à média da população da mesma idade/sexo aquando do diagnóstico (z-score: sexo masculino 0,9 e sexo feminino 0,5) e posterior perda de estatura durante a puberdade, ainda assim com estaturas finais dentro dos parâmetros da normalidade e adequadas à estatura alvo. Discussão e conclusões: embora o mau controlo metabólico pareça influenciar negativamente a velocidade de crescimento máxima e o ganho estatural pubertário, este grupo de doentes não apresentou compromisso evidente da estatura final.
Atividade Física e Função Respiratória: Análise da Composição Corporal e dos Valores Espirométricos
Authors: Paulo Rui , Petrica João , Martins Júlio
Published: October 2022

Objetivo: A presente investigação tem como principal objetivo verificar os efeitos da atividade física na composição corporal (índice de massa corporal e perímetro da cintura), nos valores espirométricos e relacionar esses indicadores com a função respiratória.Material e Métodos: A amostra, constituída por 86 indivíduos, alunos do ensino superior, com média de idade de 21,3 ± 2,4 anos, foi dividida em dois grupos: grupo de controlo constituído por 28 sujeitos sedentários (20,9 ± 1,3 anos), e grupo experimental constituído por 58 sujeitos (21,5 ± 2,8 anos) praticantes de exercício supervisionado. Para caraterizar a amostra quanto ao tipo de atividade física,aplicámos uma adaptação do questionário de Telama et al. Avaliaram-se os valores de espirometria (DEMI, VEF1 e CVF) com o espirómetro Microquark da Cosmed e os valores de índice de massa corporal e perímetro da cintura. Os dados obtidos foram tratados no S.P.S.S. 19.0, através do t-test, do teste de Levene, do teste Mann-Whitney e do teste de correlação de Spearman, adotando-se um nível de significância de 5%.Resultados: O grupo experimental obteve resultados significativamente melhores (p ≤ 0,05) nos valores de índice de massa corporal, do perímetro da cintura e em todos os valores avaliados pela espirometria (DEMI, VEF1 e CVF), comparativamente ao grupo de controlo. Verificámos também que há uma tendência para correlação negativa entre os valores da composição corporal e os valores espirométricos, apenas observável em algumas variáveis (DEMI, VEF1), ou seja, quanto maiores os valores da composição corporal, menores os valores espirométricos.Conclusão: Os alunos com prática de exercício supervisionado, apresentaram melhores índices de composição corporal e de função respiratória. Valores de índice de massa corporal e de perímetro da cintura desajustados poderão provocar disfunção respiratória, aonível da ventilação e respetivos volumes pulmonares, limitando a prática de atividade física e aumentando a apetência para patologias respiratórias.
Indicadores de Prognóstico da Carcinogénese do Colo do Útero Associada à Infeção por Vírus do Papiloma Humano
Authors: Oliveira Ana , Delgado Candida , Verdasca Nuno , Pista Angela
Published: October 2022

Introdução/Objetivos: A infeção persistente pelo Vírus do Papiloma Humano de alto risco (HPVar) é considerada como a causa necessária, embora não suficiente, para o desenvolvimento do cancro do colo do útero, sugerindo que outros fatores estarão envolvidos no processo de carcinogénese. Este estudo pretendeu avaliar indicadores de prognóstico da persistência da infeção por HPV, nomeadamente o estado físico e a carga viral dos HPV 16 e 18 e a superexpressão dos transcritos do RNAm dos HPV 16, 18, 31, 33 e 45, num grupo de mulheres com ou sem sintomatologia clínica e citopatológica. Material e Métodos: Foram estudadas 378 alíquotas de células epiteliais congeladas pertencentes a utentes dos centros de saúde do Serviço Nacional de Saúde e de clínicas privadas, referenciadas para teste HPV, entre Janeiro de 2007 e Dezembro de 2010. De acordo com o diagnóstico citopatológico, foram definidos cinco grupos: normal, ASCUS, LSIL, HSIL e carcinoma invasivo do colo do útero. Para a determinação do estado físico do DNA e da carga viral dos HPV 16 e 18 foi utilizada metodologia de PCR em tempo real, e para a superexpressão dos transcritos dos oncogenes E6 e E7 o sistema comercial NucliSENS EasyQ HPV®. Os indicadores foram analisados em associação com os tipos de lesão do colo do útero. Para a análise estatística foi utilizado o o programa informático SPSS versão 16.0 e o teste de Chi-Quadrado. Resultados: Os resultados mostraram ausência de associação estatisticamente significativa entre a gravidade da lesão e o estado físico do DNA dos HPV 16 e 18. A superexpressão dos transcritos do RNAm E6/E7 e a carga viral dos HPV 16 e 18 aumentaram significativamente em função do grau da lesão. Conclusões: Os resultados obtidos sugerem que a determinação do estado físico do DNA dos HPV 16 e 18, isoladamente, não constitui um indicador de prognóstico para o desenvolvimento e progressão das lesões. A superexpressão dos transcritos dos oncogenes E6 e E7 está associada à progressão das lesões do colo do útero e apresenta maior especificidade no diagnóstico precoce das lesões pré-malignas. A quantificação do DNA dos HPVar pode ser um indicador promissor de prognóstico das lesões pré-neoplásicas do colo do útero.
Pesquisas sobre atingidos por barragens no Brasil
Authors: Bittiol Adriana Fanali , Parolin Mauro , Stevanato Mayra
Published: October 2022

O artigo caracteriza a produção acadêmica sobre estudos socioambientais de populações atingidas por barragens de hidrelétricas no Brasil, nos Programas de Pós-Graduação (PPG) stricto sensu, bem como artigos revisados por pares e publicados em revistas especializadas. O estudo bibliográfico investiga o período de 2016 a 2022. Os dados foram sistematizados em forma de mapas e gráficos utilizando o software Quantum Gis®, assinalando as regiões onde se desenvolvem os estudos relacionados, as instituições de origem, os cursos e áreas que desenvolveram os trabalhos, as usinas mais pesquisadas, além do enfoque e métodos utilizados nas pesquisas. Nos últimos anos, a região Norte do Brasil é responsável pelo maior número de estudos (23) socioambientais que focalizam populações atingidas por barragens. Os conhecimentos e resultados podem nortear futuras investigações e são importantes na consolidação de novas pesquisas sobre estudos socioambientais e populações atingidas por barragens.
Docência Universitária no curso de Pedagogia Intercultural Indígena da Universidade do Estado de Mato Grosso: reflexões insurgentes
Authors: Azinari Amanda Pereira da Silva , Monteiro Filomena Maria de Arruda
Published: October 2022

Apresentamos reflexões parciais do Projeto de Tese de Doutorado em Educação vinculado ao Programa de Pós-Graduação na região Centro-Oeste do país, na linha de pesquisa Organização escolar, formação e práticas pedagógicas. O texto compõe sentidos construídos a partir das experiências formativas e de trabalho da primeira autora com a Faculdade Indígena Intercultural da Universidade do Estado de Mato Grosso (FAINDI/UNEMAT), como também de reflexões emergidas no Grupo de Estudos e Pesquisas em Política e Formação Docente (GEPForDoc). O texto organiza-se em três momentos: inicialmente, abordamos a pesquisa bibliográfica sobre a docência universitária e o desenvolvimento profissional docente no contexto intercultural; na sequência, apresentamos o debate sobre o magistério e a criação do 3º grau indígena e da FAINDI/UNEMAT; por último, apresentamos os relatos de experiências de docência com o curso de Pedagogia Intercultural, ancorados em uma escrita-narrativa autobiográfica, aproximando-se da pesquisa narrativa de Clandinin e Connelly (2015).
O mercado de citação das autorias indígenas no Brasil: um estudo político (2016-2024)
Authors: Lopes Danielle Bastos , Luiz Juliana Rios
Published: October 2022

O presente artigo apresenta uma extensão empírica de uma pesquisa que explorou os dados relativos às autorias indígenas em periódicos científicos no Plano Nacional do Livro Didático (PNLD – 2020 - 2024) e, adicionalmente, um estudo de caso em um instituto considerado como uma das escolas de maior pontuação em rankings de avaliação na região Sudeste brasileira. Portanto, decorre de análise quantitativa e qualitativa, partindo do pressuposto de que “a escrita de si indígena” é radicalmente múltipla e descentrada da noção de um indivíduo puramente humano, moderno e universalista. Em um segundo momento, nas análises qualitativas, investiga a geografia das citações e a influência das enunciações indígenas escolhendo, para tanto, algumas obras do PNLD e materiais didáticos que trouxeram elocuções ameríndias em maior repetição. No curso desta análise, serão discutidos temas minoritários e agendas muito evidenciadas nos últimos anos pela Lei 11.645/08, que tornou obrigatória a inserção dos estudos indígenas e africanos nas produções literárias. O reconhecimento de autorias indígenas nos mercados de citação geopolítico global, revela a existência de conhecimentos que passam a se erguer em direção de espaços antes nunca ocupados. Contudo, a partir dos resultados da pesquisa foi observado o esvaziamento dessas mesmas autorias em primeira pessoa em materiais didáticos e/ou periódicos científicos. O artigo trata, portanto, da interpelação dos materiais escolares/científicos em uma pesquisa que envereda pela escrita de si, pela economia das citações e, finalmente, pelos efeitos da diferença no âmbito escolar.
Biological Nurturing Baby-led Feeding to Reduce the Pain Intensity of Post-Section Caesarian: A Quasi-Experimental Study
Authors: A’inurrohmah Siti , Mukhoirotin Mukhoirotin
Published: October 2022

Introduction: Caesarean surgery can cause pain that affects mobilization, daily activities, and the process of breastfeeding the baby. Baby-led feeding is one of the recommended breastfeeding positions for postpartum mothers post-Caesarean because it feels more relaxing. However, the effectiveness of baby-led feeding at reducing the pain levels needs further research. This study therefore aimed to determine the effect of baby-led feeding on the pain intensity among post-Caesarean section patients.Methods: The research design used was quasi-experiment with a pre-test-post-test control group design and multi-stage sampling. This totaled 26 respondents across the two groups. The biological nurturing baby-led feeding treatment was given every feeding time. The research instrument used was the Numeric Rating Scale (NRS), and the data was analyzed using a Paired Sample T-Test and an Independent Sample T-Test with α ≤ 0.05.Results: This study showed there to be an effect of biological nurturing baby-led feeding on the pain intensity experienced by the patients with a p-value of 0.000 (p≤0.05). There were significant differences in pain intensity between the intervention and control groups with a p-value of 0.001 (p≤0.05).Conclusion: Biological nurturing in the form of baby-led feeding is effective at reducing the pain intensity of post-Caesarean section patients. Further research recommends that post-intervention pain observations be carried out on the first day after the baby-led feeding intervention is initiated.
Cancer resistance to immunotherapy: What is the role of cancer stem cells?
Authors: Gupta Gourab , Merhej George , Saravanan Shakthika , Chen Hexin
Published: October 2022

Immunotherapy is an emerging form of cancer therapy that is associated with promising outcomes. However, most cancer patients either do not respond to immunotherapy or develop resistance to treatment. The resistance to immunotherapy is poorly understood compared to chemotherapy and radiotherapy. Since immunotherapy targets cells within the tumor microenvironment, understanding the behavior and interactions of different cells within that environment is essential to adequately understand both therapy options and therapy resistance. This review focuses on reviewing and analyzing the special features of cancer stem cells (CSCs), which we believe may contribute to cancer resistance to immunotherapy. The mechanisms are classified into three main categories: mechanisms related to surface markers which are differentially expressed on CSCs and help CSCs escape from immune surveillance and immune cells killing; mechanisms related to CSC-released cytokines which can recruit immune cells and tame hostile immune responses; and mechanisms related to CSC metabolites which modulate the activities of infiltrated immune cells in the tumor microenvironment. This review also discusses progress made in targeting CSCs with immunotherapy and the prospect of developing novel cancer therapies.
EDUCAÇÃO GEOGRÁFICA E LITERATURA: O POTENCIAL DA POESIA DE RUY ESPINHEIRA FILHO PARA O ENSINO MÉDIO DE CIÊNCIAS HUMANAS E SOCIAIS APLICADAS
Authors: AMAURY PEREIRA LIMA PABLO , MACHADO ROCHA BUSCH PEREIRA Carolina
Published: October 2022

O trabalho tem como objetivo relacionar a Literatura à Geografia, a partir da obra poética de Ruy Espinheira Filho, poeta baiano que em seus poemas traz sentimentos a respeito dos seus lugares vividos. Nosso intento é evidenciar o potencial que a literatura tem como aporte à educação geográfica com foco na área de conhecimento das Ciências Humanas e Sociais Aplicadas. Buscando uma interface entre a Geografia e a Literatura e reconhecendo que a educação geográfica tem caminhos que permitem arranjos em propostas didático-pedagógicas interdisciplinares, o artigo busca incitar o uso da literatura como uma das fontes de conhecimento que devem ser desenvolvidas transversalmente ao ensino dos componentes curriculares integrados a área de Ciências Humanas e Sociais Aplicadas. Tendo em vista que a literatura possibilita a junção dos diversos componentes curriculares em discussões que facilitam a visualização de diversas problematizações, o seu uso na presente proposta assume o sentido de linguagem, recurso e meio facilitador do desenvolvimento de competências e habilidades definidas pela BNCC (BRASIL, 2018). A obra de Ruy Espinheira Filho, aqui trazida através de coletâneas de poemas publicadas em 2012 e 2017 e que representam sua poesia desde a década de 1960, é usada como exemplo da riqueza de relações que a literatura tem para o desenvolvimento de questões históricas, geográficas e sociais, além de contribuir para a ampliação do repertório cultural dos estudantes e promoção do conhecimento científico historicamente construído pela sociedade.
OLHAR SOBRE OS CRITÉRIOS METODOLÓGICOS DO ENSINO DE GEOGRAFIA A PARTIR DE HERCULANO CACHINHO: PREMISSAS AO DESENVOLVIMENTO DO RACIOCÍNIO GEOGRÁFICO
Authors: LEITE ALVARENGA BOTELHO LÚCIO
Published: October 2022

Este trabalho é dedicado a apresentar os critérios metodológicos no pensamento de Herculano Cachinho para o Ensino de Geografia. Por conseguinte, observamos aspectos sobre a prática operativa, o processo de investigação, a importância da metodologia de ensino e as alterações nas práticas docentes, dentre outros. Ao refletir sobre tais critérios levantados por Cachinho, é possível observar como o autor encaminha questões que vão ao encontro do desenvolvimento do raciocínio geográfico. Mediante uso de revisão bibliográfica, serão apresentadas as ideias de Cachinho (1991, 2000) que se encontram nesta direção, as quais, colocaremos, ao longo do texto, em dialogo com outros autores do campo do Ensino de Geografia. Nosso objetivo é gerar reflexões sobre os critérios metodológicos e os desdobramentos na prática docente que possam contribuir para a discussão acerca da aplicação do desenvolvimento do raciocínio geográfico nas aulas de Geografia, nos auxiliando a responder: Qual é a importância de se desenvolver o raciocínio geográfico?
IDEOLOGIA DESENVOLVIMENTISTA E O DISCURSO REGIONALISTA NO TOCANTINS
Authors: DE SOUZA SANTOS ROBERTO
Published: October 2022

O presente artigo tem por objetivo abordar sobre a ideologia desenvolvimentista e sobre o discurso regionalista no Tocantins. A intenção do texto é comentar e analisar o papel da ideologia desenvolvimentista e o discurso regionalista quando ganham terreno nas questões que envolvem o poder político e econômico para as classes sociais da aristocracia agrária e para a burguesia capitalista e, sobretudo, para a classe política de mandato eletivo como Presidente da República, governadores e parlamentares. O discurso ideológico é também político. No caso da criação do Tocantins, o discurso regionalista surge com o objetivo de formar um imaginário social e cultural e político para despertar na população a necessidade de divisão do estado de Goiás, para alavancar o desenvolvimento regional do Norte goiano. O imaginário é uma força atuante no mundo das ideias e da representação mental das imagens e, parte do pressuposto de que todo pensamento humano é representação que passa pela mediação simbólica – política, ideológica e cultural. Os procedimentos metodológicos para a elaboração do texto passaram por uma revisão bibliográfica de textos e teóricos que debatem sobre o tema em pauta. O que observamos é que a aristocracia agraria regional tocantinense elaborou um discurso em que a divisão do estado de Goiás, seria uma das alternativas para o progresso, a prosperidade e desenvolvimento econômico e social da região Norte goiana que atualmente é o estado do Tocantins.
POSSIBILIDADES DIDÁTICO-PEDAGÓGICAS SOBRE O ENSINO DE CERRADO NAS AULAS DE GEOGRAFIA NA EDUCAÇÃO BÁSICA
Authors: CAPELLE SUESS RODRIGO , FERREIRA FARIAS DA CUNHA LEONARDO
Published: October 2022

O objetivo deste texto é analisar as possibilidades de abordagens da apropriação e utilização do Cerrado na Região Centro-Oeste, especialmente, ao que se refere ao conteúdo e possibilidades didático-pedagógicas nas aulas de Geografia na Educação Básica. A abordagem adotada é qualitativa e os procedimentos utilizados foram a pesquisa bibliográfica e a análise das informações que subsidiaram reflexões dos autores. Foi possível concluir que o trabalho com a categoria espaço geográfico e os conceitos operacionais da Geografia fornece um conjunto de possibilidades e indica necessidades de mudanças que precisam se efetivar nas práticas docentes de Geografia na Educação Básica. Essa construção do conhecimento permite a compreensão do Cerrado na Região Centro-Oeste como um ambiente com biodiversidade e sociodiversidade, que se relacionam e se cruzam compondo combinações únicas que dotam esse espaço de especificidades, e possibilita uma mudança radical de mentalidade, do modo de vida, das relações de produção e substituição da lógica da destruição por um desenvolvimento mias justo e harmonioso.
Pengaruh Religiusitas dan Welas Asih Diriterhadap Kesejahteraan Psikologis Orang Tua Anak Berkebutuhan Khusus
Authors: Isnaeni Rizki , Nashori H. Fuad
Published: October 2022

Orang tua yang memiliki anak berkebutuhan khusus merasakan beban secara fisik dan psikis yang berat. Penelitian ini bertujuan untuk mengetahui pengaruh religiusitas dan welas asih diri (self-compassion) terhadap kesejahteraan psikologis orang tua yang memiliki Anak Berkebutuhan Khusus (ABK). Responden dalam penelitian ini adalah 107 orang tua ABK yang berdomisili di Kota Makassar. Hipotesis yang diajukan dalam penelitian ini adalah terdapat pengaruh religiusitas dan welas asih diri terhadap kesejahteraan psikologis pada orang tua ABK. Pengambilan data dalam penelitian ini menggunakan skala religiusitas yang dikembangkan oleh Nashori (2012), skala kesejahteraan psikologis oleh Ryff dan Keyes (1995) yang telah diadaptasi ke dalam Bahasa Indonesia oleh Azalia et al. (2018), skala Self-Compassion disusun oleh Neff (2003) yang telah diadaptasi ke dalam Bahasa Indonesia oleh Sugianto et al. (2020). Data dari hasil penelitian dianalisis dengan menggunakan teknik analisis regresi berganda. Hasil penelitian menunjukkan bahwa terdapat pengaruh yang positif dan signifikan religiusitas dan welas asih diri terhadap kesejahteraan psikologis. Program untuk menunjang religiusitas dan welas asih diri diperlukan bagi orang tua dengan ABK.
Panggilan (Calling) dan Kesejahteraan di Tempat Kerja pada Karyawan Kehutanan
Authors: Reihan Firmansyah Kresna , Riasnugrahani Missiliana
Published: October 2022

Working conditions with a high risk of safety and health can reduce employees’ well- being in the workplace. Well-being in the workplace is essential in supporting employee performance that prevents employees from error and negligent behavior. Therefore, this study aims to determine the relationship between calling and well-being for forestry employees. Our hypothesis is search for calling dimension has a negative correlation with employees’ well-being at work, and the presence of calling has a positive correlation with employees’ well-being at work. Through the purposive sampling technique, 130 employees are willing to participate in this study. Data collection uses the Calling and Vocation Questionnaire (CVQ) and the Eudaimonic Well-being at Work Scale (EWWS), with high-reliability scores. The results of data analysis showed that both the dimensions of calling–search and the presence–had a significant positive relationship with well-being at work. Employees who seek a calling, and those who perceive a calling, feel a sense of well-being at work.
Energy Policy for Agrivoltaics in Alberta Canada
Authors: Jamil Uzair , Pearce Joshua M.
Published: October 2022

As Alberta increases solar power generation, land use conflicts with agriculture increase. A solution that enables low-carbon electricity generation and continued (in some cases increased) agricultural output is the co-locating of solar photovoltaics and agriculture: agrivoltaics. This study reviews policies that impact the growth of agri-voltaics in Alberta. Solar PV-based electricity generation is governed by three regula-tions based on system capacity. In addition, agrivoltaics falls under various legisla-tions, frameworks, and guidelines for land utilization. These include Land Use Frame-work, Alberta Land Stewardship Act, Municipal Government Act, Special Areas Dis-position, Bill 22 and other laws/policies all of which are reviewed in the context of agrivoltaics. Several policies are recommended to support rapid diffusion of agrivolta-ics. First, open access research into agrivoltaics, which not only will help optimize agrivoltaic systems for the region, but also coupled with public education is expected to galvanize social acceptability of large-scale PV deployment. Clearly defining and categorizing agrivoltaic technology, developing agrivoltaic standards, making agri-voltaic technology-friendly regulations/frameworks and developing programs and pol-icies to incentivize agrivoltaic deployment over conventional PV will all accelerate dif-fusion. Through these measures, Alberta can achieve conservation and sustainability in food and energy sector while simultaneously addressing the renewable energy and climate-related goals.
Diatomic Line Strengths for Fitting Selected Molecular Transitions of AlO, C2, CN, OH, N2+, NO, and TiO, Spectra
Authors: Parigger Christian G
Published: October 2022

This work communicates line strength data and associated scripts for computation and spectroscopic fitting of selected transitions of the diatomic molecules AlO, C2, CN, OH, N2+, NO, and TiO. For ease of use, the scripts for data analysis are designed for inclusion in various software packages or program languages. The accuracy of the data is of the order of less than one picometer, suitable for analysis of laser-induced fluorescence and laser-plasma spectra. Selected results demonstrate the applicability of the program for data analysis in laser-induced optical breakdown spectroscopy primarily at The University of Tennessee Space Institute, Center for Laser Applications. Representative spectra are calculated and referenced to measured data records.
Assessment of Relative Accuracy of TxRR and NWM in Simulating Streamflow for a Cluster of Watersheds along the south Texas Coast
Authors: Rahman Md Arifur , Zhang Yu , Ghazvinian Mohammadvaghef , Fernando Nelun , Schoenbaechler Caimee , Gan Yanjun
Published: October 2022

Study Region -This study is conducted for a cluster of watersheds within the Matagorda Basin along the south Texas coast in the United States. Study Focus - Retrospective streamflow simulations of two hydrologic models of contrasting formulations and complexity, namely the TxRR, a simple analog model, and the National Water Model (NWM), a land surface-hydrologic model that explicitly accounts for surface energy balance in calculating water budget, and whose output. The comparison was motivated by a) the need for improving the modeling of runoff dynamics for watersheds along central Texas coast through the introduction of NWM to inform freshwater inflow monitoring and flood planning, and b) the need to better understand the potential ability of the NWM to address shortcomings of TxRR related to the latter’s mechanistic deficiencies in a region known for hydroclimatic extremes. The study focuses on the temporal scale and climate dependence in the relative performance of the two models, the behaviors of models during extreme floods and droughts, and the relative efficacy of parameter transfer schemes. It further seeks to relate the performance differentials to model physics and calibration approaches. New Hydrologic Insights – NWM, with sophisticated representations of energe closure, is advantageous to TxRR in capturing low-frequency (interannual) variations in streamflow modulated by the surface energy balance, as evidenced by the superior correlation of its streamflow simulations at the interannual range. Yet, its overall performance trails behind TxRR at daily scale, and it tends to underpredict runoff volumes during two major floods. These features underscore the tendency of the model to suppress soil moisture at the onset of these events. On the other hand, TxRR outperforms in reproducing the volumes for the flooding events, but it overpredicts runoff during the extreme drought episode of 2011, likely an outcome of inadequate representation of the impacts of root zone soil moisture in regulating runoff. TxRR’s parameteralization scheme proves more effective for adaptation across watersheds due to the presence of steep gradation in soil properties .
Thermal Response in Two Models of Socks with Different 3-D Weave Separations
Authors: Sánchez-Rodríguez Raquel , Gómez-Martín Beatriz , Escamilla-Martínez Elena , Morán-Cortés Juan Francisco , Martínez-Nova Alfonso
Published: October 2022

Socks with the same three-dimensional plantar design, but with different compositions in the separation of their weaves could have different thermoregulatory effects. The objective of this study was therefore to evaluate the temperatures on the sole of the foot after a 10-km run, using two models of socks with different weave separations. In a sample of 20 individuals (14 men and 6 women), plantar temperatures were analysed using a Flir E60bx® (Flir Systems) thermographic camera before and after a run of 10 km wearing two models of socks that had different separations between the fabric weaves (5 mm versus 3 mm). After the post-exercise thermographic analysis, the participants responded to a Likert type survey to evaluate the physiological characteristics of the two models of socks. There was a significant increase in temperature in the areas of interest (p<0.001) after the 10-km run with both models of sock. The temperature under the 1st metatarsal head was higher with the AWC 2.1 model than with the AWC 1 (33.6±2.0°C vs 33.2±2.1°C) (p = 0.014). No significant differences were found in the scores on the physiological characteristics comfort survey (p>0.05 in all cases. The two models presented similar thermoregulatory effects on the soles of the feet, although the model with the narrowest weave separation generated greater temperatures (+0.4°C) under the first metatarsal head.
Four-Parameter Guessing Model and Related Item Response Models
Authors: Robitzsch Alexander
Published: October 2022

Guessing effects frequently occur in testing data in educational or psychological applications. Different item response models have been proposed to handle guessing effects in dichotomous test items. However, it has been pointed out in the literature that the oftenemployed three-parameter logistic model poses implausible assumptions regarding the guessing process. The four-parameter guessing model has been proposed as an alternative to circumvent these conceptual issues. In this article, the four-parameter guessing model is compared with alternative item response models for handling guessing effects through a simulation study and an empirical example. It turned out that model selection for item response models should be rather based on the AIC than the BIC. However, the RMSD item fit statistic used with typical cutoff values was found to be ineffective in detecting misspecified item response models. Furthermore, sufficiently large sample sizes are required for sufficiently precise item parameter estimation. Moreover, it is argued that the criterion of statistical model fit should not be the sole criterion of model choice. The item response model used in operational practice should be valid with respect to the meaning of the ability variable and the underlying model assumptions. In this sense, the four-parameter guessing model could be the model of choice in educational large-scale assessment studies.
Field, Courting Sanctity: Holy Women and the Capetians (Cornell University Press, 2019)
Authors: Nolan Kathleen
Published: October 2022

Review of Sean Field, Courting Sanctity: Holy Women and the Capetians (Ithaca: Cornell University Press, 2019)
Evans, Royal Voices: Language and Power in Tudor England (Cambridge University Press, 2020)
Authors: Purdy Jessica Grace
Published: October 2022

Review of Mel Evans, Royal Voices: Language and Power in Tudor England (Cambridge: Cambridge University Press, 2020).
Hefferan, The Household Knights of Edward III: Warfare, Politics and Kingship in Fourteenth-Century England (Woodbridge, 2021)
Authors: Lane Samuel
Published: October 2022

Review of Matthew Hefferan, The Household Knights of Edward III: Warfare, Politics and Kingship in Fourteenth-Century England (Woodbridge: The Boydell Press, 2021).
Greenhouse gas emissions from hydroelectric reservoirs: Mechanistic understanding of influencing factors and future prospect
Authors: Kumar Amit , Kumar Amit , Chaturvedi Ashish K. , Joshi Neeshu , Mondal Raju , Malyan Sandeep K
Published: October 2022

Since the pre-industrial era (1990s), greenhouse gas (GHG) emissions from hydroelectric reservoirs have been a debatable subject of interest due to a substantial contribution to global warming. Rising demand for various renewable and non-renewable energy resources became necessary for rapid economic growth to the exponentially rising population in developing countries. Reducing GHG emissions is the key target of COP-26 for climate change mitigation. However, precise methodologies for quantification of GHG, key parameters affecting emission rate is a challenging task attributed to limited tools, techniques for GHG measurement, uncertainty rate in measurement, insufficient GHG database, and huge spatio-temporal variability of emission in global reservoirs. This work highlights the present scenario of GHG emissions from renewable energy with targeted approach on hydroelectric reservoirs, methodological know-how, interrelation between parameters affecting GHG emission, and mitigation strategies. Apart from this, major tools and techniques to predict GHG emissions from hydroelectric reservoirs, accounting of GHG emissions, life cycle assessment, sources of uncertainty, and knowledge gaps have been discussed in detail.
Critical factors identification of digital innovation in manufacturing enterprises: Three stage hybrid DEMATEL-ISM-MICMAC approach
Authors: Feng Xiangqian , Li Eryang , Li Jian
Published: October 2022

In the era of digital economy, the digital innovation of manufacturing enterprises has become the main trend of development. This paper constructs an effective and reliable hierarchical framework for identifying critical factors of digital innovation in manufacturing enterprises based on the three stage hybrid DEMATEL-ISM-MICMAC method. Through literature reading and expert judgment, this paper determines the 19 factors that affect the digital innovation of manufacturing enterprises. The DEMATEL technique is used to establish the causal relationship between the factors, the ISM technique is used to stratify the factors, and the MICMAC technique is used to divide the types of influencing factors according to the driving force and dependence, and analyze the correlation between each level and its influence on the digital innovation of manufacturing enterprises. The results show that social capital, learning organization, digital technology, and knowledge are the most important influencing factors in the process of digital innovation in manufacturing enterprises. In particular, the two key factors of social capital and learning organization should be paid attention to by manufacturing enterprises. This research can help the managers of manufacturing enterprises to find out the key influencing factors of the digital innovation of manufacturing enterprises, and give targeted suggestions to promote the process of enterprise digitalization.
A new photocatalyst: triple heterojunction Yb3+-Bi2O3/BiOIO3 catalyst for mercury removal from flue gas
Authors: Ren Siyuan , Li Tong , Wu Jiang , Zhou Min , Peng Cheng , Zhang Hai , He Ping , Qi Xuemei , Song Mao , Zhou Yuzhuo , Chen Shuo
Published: October 2022

The Yb3+-Bi2O3/BiOIO3 triple heterojunction photocatalyst was successfully prepared by the EG assisted hydrothermal method and the calcination method. Bi2O3 has a variety of crystal phase structures. Through characterizations and DFT theoretical calculations, it is shown that different proportion of Yb3+ doping makes the lattice phase transition of Bi2O3. When the mole ratio of Yb3+ doping in the complex is 1%, the coexistence and recombination of α-Bi2O3, β-Bi2O3 and BiOIO3 lead to the formation of triple heterojunction and the establishment of a unique electronic transmission channel, which promote the separation of photogenerated carriers. At the same time, Yb3+ ions have unique electronic transition characteristics, which effectively broaden the spectral response range of the Yb3+-Bi2O3/BiOIO3 photocatalyst, and also improve the photocatalytic activity. Thanks to its optimized performance, the best efficiency of the Yb3+-Bi2O3/BiOIO3 triple heterojunction photocatalyst in removing gaseous Hg0 under visible light can reach 76.73%, which is much higher than that of its pure component. Finally, the mechanism of high efficiency catalytic oxidation was proposed by combining rare earth ion doping with semiconductor recombination to construct heterojunction catalysts with a wide spectral response. This work provides a new method for designing efficient photocatalysts.
Robust chaos and multi-stability in piecewise linear recurrent neural networks
Authors: Monfared Zahra , Patra Mahashweta , Durstewitz Daniel
Published: October 2022

Recurrent neural networks (RNNs) are major machine learning tools for the processing of sequential data. Piecewise-linear RNNs (PLRNNs) in particular, which are formally piecewise linear (PWL) maps, have become popular recently as data-driven techniques for dynamical systems reconstructions from time-series observations. For a better understanding of the training process, performance, and behavior of trained PLRNNs, more thorough theoretical analysis is highly needed. Especially the presence of chaos strongly affects RNN training and expressivity. Here we show the existence of robust chaos in 2d PLRNNs. To this end, necessary and sufficient conditions for the occurrence of homoclinic intersections are derived by analyzing the interplay between stable and unstable manifolds of 2d PWL maps. Our analysis focuses on general PWL maps, like PLRNNs, since normal form PWL maps lack important characteristics that can occur in PLRNNs. We also explore some bifurcations and multi-stability involving chaos, since the co-existence of chaotic attractors with other attractor objects poses particular challenges for PLRNN training on the one hand, yet may endow trained PLRNNs with important computational properties on the other. Numerical simulations are performed to verify our results and are demonstrated to be in good agreement with the theoretical derivations. We discuss the implications of our results for PLRNN training, performance on machine learning tasks, and scientific applications.
Mathematics Subject Classification (2020) 37F46 · 34H10
Pharmacokinetic study of Yindan Xinnaotong soft capsule after oral administration in rats and its network pharmacology-based analysis on cardiovascular diseases
Authors: Li Jun-Ming , Huang An-Xian , Yang Liu , Gao Wen
Published: October 2022

Background
Yindan Xinnaotong soft capsule (YDXNT) is a Chinese herbal preparation, which was used to treat coronary disease, angina, hyperlipidemia and stroke in the clinic. The chemical ingredients of YDXNT have been investigated, but the pharmacokinetic study of the absorbed components of YDXNT and the exploration of their effect on cardiovascular diseases (CVD) are still insufficient.
Method
A sensitive and accurate quantitative method based on ultra-high performance liquid chromatography tandem triple quadrupole mass spectrometry (UHPLC-QQQ MS) was established and validated, which was then applied to the pharmacokinetic study of the potential active compounds in the plasma of rats after oral administration of YDXNT. Then the measured analytes were regarded as effective compounds and their potential targets and mechanism of action were predicted after the construction and analysis of compound-target network of YDXNT and CVD.
Results
The UHPLC-MS based quantitative method was verified to have acceptable linearity, specificity, accuracy, precision, matrix effect, extract recovery and stability for pharmacokinetic analysis, and 15 absorbed compounds in rat plasma after oral administration of YDXNT was studied. Different types of compounds showed various pharmacokinetic characteristics, for instance, ginkgolides with higher maximum plasma concentration (Cmax), flavonoid presenting concentration-time curve with double peaks, phenolic acids with shorter time to reach maximum plasma concentration (Tmax), saponins with long elimination half-life (t1/2) and tanshinones showing fluctuant plasma concentration. Then a network pharmacology-based analysis indicated that those potential active compounds of YDXNT interacted with targets such as MAPK1 and MAPK8, and intervened in the MAPK signaling pathway to display its therapeutic effect on CVD.
Conclusion
The pharmacokinetics combined network pharmacological analysis provides the potential pharmacological compounds and their integrating mechanism of YDNXT against CVD.
Multi Level Bank Locker Security System with Digital Signature Authentication and Internet of Things
Authors: Islam Md. Ashiqul , Sarder Md. Sumon , Mamun Mehedi Hasan , Ahmed Faruq , Sarkar Sujit Kumar , Mridul Aunik Hasan , Ahmed Md. Tanvir , Khatun Tania
Published: October 2022

Recently bank security is being a matter of great awareness and importance in the world. Though, we designed a multi-layer Bank security system to preserve the bank locker from stealing and unauthorized access. A multi-layer bank locker security system can be legalized, and monitored and prevent security in a bank locker room or unauthorized access. This security system is a highly reliable multi-level security system to protect lockers. This banking security system with a high-security two-door system, multi-layer wall based on infrared radiation and GSM technology, sensors such as sound sensor, motion sensor, laser sensor, gas sensor, IP camera, microcontroller keyboard, LCD monitor, etc. There is a biometric system, such as an iris scanner with a fingerprint scanner and a unique RFID card that protects the main door of the locker room and infrared rays pass from the infrared radiation source into the parallel section of the wall to prevent any accidents such as wall breaks. SMS are sent to the officials if the camera is detected any unauthorized motion and the alarm is on to warn the officials. People are accessing their bank lockers in the waiting room, and robotic arms are searching their lockers where they can sign the digital signature, enter the PIN and locker number in the second door keypad and they can access their locker using a message authentication system and locker key. After accessing the locker they can click the exit button and the robotic arms put the locker in the right place. This multi-level security system is more secure to protect the bank locker and safe transactions.
Protomer Selectivity of RAF Inhibitors Within the RAS/RAF Signalosome
Authors: Vasta James , Michaud Ani , Zimprich Chad , Thomas Morgan , Wilkinson Jennifer , Crapster J. Aaron , Robers Matthew
Published: October 2022

RAF dimer inhibitors offer therapeutic potential in RAF- and RAS-driven cancers. The utility of such drugs is predicated on their capacity to occupy both RAF protomers in the RAS-RAF signaling complex. Here we describe a method to conditionally quantify drug-target occupancy at selected RAF protomers within an active RAS-RAF signalosome in cells. RAF target engagement can be measured in the presence or absence of any mutant KRAS allele, enabling the high affinity state of RAF dimer inhibitors to be quantified in the cellular milieu. The intracellular selectivity of clinical-stage drugs for individual protomers within BRAF, CRAF, and ARAF heterodimers in complex with mutant KRAS-GTP revealed that ARAF protomer-engagement, but not engagement of BRAF or CRAF is commensurate with inhibition of MAPK signaling in various mutant RAS cell lines. Our results support a fundamental role for ARAF in mutant RAS signaling and highlight the avoidance of ARAF protomers for a cohort of RAF inhibitors undergoing clinical evaluation.
Female calling and copulation behaviour of Indian population of an invasive pest, Spodoptera frugiperda (J. E. Smith, 1797)
Authors: Ramya Nagaraju , Sagar Doddachowdappa , Kumar Padala Vinod , Rupali Jagadam Sai , Kumar Hemant , Reshma Ramankutty , Yadav Priya , Seth Rakesh Kumar
Published: October 2022

An experiment was conducted to study and document the copulation duration and effect of mating on female calling behaviour of Indian population of an invasive pest, Spodoptera frugiperda (J. E. Smith). Results showed that 58.39% of the females in absence of males and 88.18% of females in presence of males exhibited calling on first scotophase and onset time of calling was early in females in presence of males. Calling length and calling bouts varied significantly with increase in age in virgin females, while in multiple mated females it showed declining trend. The copulation duration of S. frugiperda varied between 78.00±7.35 min to 197.14±11.06 min with maximum copulation duration and percentage of females mated was observed on second scotophase. The fecundity of multiple mated females ranged between 841 to 1849 with mean of 1176±113 while in single mated females it ranged between 476 to 1368 with mean of 878±175. Practically our results indicated that the calling and mating takes place on first scotophase and it was on peak in second scotophase. This information can be used in formulating biorational molecules, which may modulate calling behaviour and improve mating disruption in S. frugiperda for its management.
Prognostic and Immunological Role of RBMX in cancers
Authors: Sheng Yilei , Tu Zewei , Sun Chengpeng , Long Xiaoyan , Wu Lei , Huang Kai , Zhu Xingen
Published: October 2022

Cancer, as the disease causing the highest morbidity and mortality worldwide, attracted all kinds of research investment but received little effect. RBMX, a nuclear RNA binding protein, verified to associated with certain types of cancer through participating in integration of sister chromatids and combination of ribonucleoprotein complex. However, the specific role of RBMX in pan-cancer remains unknown. This article presents the robust role of RBMX in predicting the immunotherapy response and screening the effective prognostic biomarker for cancer therapy. Here, we did comprehensive of RBMX using the sample from the Genotype-Tissue Expression (GTEx) datasets and TCGA pan-cancer cohort. We present experimentally that RBMX’s independent role in prediction and diagnosis. In the future, RBMX blocking-up may become a novel method in cancer therapy.