bluuebunny/crossref_metadata_2025 huggingface dataset:
Cleaning Validation of a Multipurpose Plant for Active Pharmaceutical Ingredient Bulk Production
Authors: Moser Mirko , Calderari Giorgio , Morini Paolo
Published: May 2022

One of the key issues in the manufacture of active pharmaceuticals ingredients in multipurpose non-dedicated equipment is to adequately address the potential for cross-contamination. It is therefore important for a production manager to have a scientifically based and organisationally
robust cleaning validation concept and program, where resources are neither over- or under-committed. In this paper technical tools, such as implementation of disassembling and cleaning SOPs, the implementation of cleaning and control levels, the definition of acceptance criteria, the execution
of swab and rinse sampling methods, the development and validation of analytical methods, the use of worse-case tests, the definition of equipment-train and the preparation of validation protocols will be discussed. A cleaning validation program generates a huge amount of data. At Helsinn
this data is processed, analysed and evaluated by means of tri-dimensional matrices. Cleaning validation programs have brought significant technical results that have led to production performance increases. Among them: The adopted model has permitted validation of the cleaning system in an
overall manner for the entire production unit and for all products in question. It permits constant monitoring of the system and rapid theoretical verification of the impact of introducing new process/production runs. Allows earlier identification of critical cases where intervention with
preventative solutions to avoid cross-contamination by use of more sophisticated cleaning/sampling/analysis methods can be implemented. The standardisation of methods for cleaning and analysis, and the introduction of the concept of cleaning levels, leading to faster product changeovers. The
management has further criteria for the evaluation of new processes prior to introduction into the plant.
La répétition dans les manuels épistolaires de l’âge classique : l’exemple de la « lettre de demande »
Authors: TARDY Cécile , ANQUETIL Sophie
Published: May 2022

Parmi les genres de l’Ancien Régime, le « secrétaire » (ou manuel épistolaire) est l’un de ceux où les phénomènes de répétition sont les plus manifestes. Le manuel fait en effet alterner consignes prescriptives et florilèges, et édicte des règles parfois proches d’une lettre à l’autre (et même, d’une section à l’autre). Ainsi se mettent en place des routines d’écriture. Fondée sur la théorie des actes de langage, notre étude s’emploiera à montrer comment les postures énonciatives de l’émetteur, et son projet pragmatique, conditionnent des « blocs » d’actes illocutoires ‑ appelés co‑illocutions (Anquetil, 2012, 2013, 2017) ‑ et quels en sont les marqueurs linguistiques (sur le plan énonciatif, sémantique, lexical ou encore syntaxique). En nous appuyant sur un corpus de manuels qui s’échelonne sur toute la période de l’âge classique ‑ du Secrétaire de la Cour de J. Puget de la Serre (1625) à La Rhétorique de l’honnête homme, ou la manière de bien écrire des lettres de P. Colomiès (1699) ‑ nous montrerons comment les marqueurs employés révèlent le type d’interaction qui s’établit entre l’émetteur et le destinataire ainsi que les enjeux sociétaux qui en découlent. Il s’agira aussi, à travers l’étude des marqueurs, de mettre au jour les stratégies employées, et sans doute institutionnalisées ici, permettant de faire admettre la nécessité d’une transformation du monde existant, par le biais de principes de légitimation. Enfin, notre étude aura pour finalité de repérer les récurrences structurelles, d’identifier les routines d’écriture qui se dégagent des manuels – que ce soit au sein d’un même ouvrage (en confrontant préceptes et mises en application) ou d’un ouvrage à l’autre.
Expliquer une pathologie « invisible » au patient. L’emploi d’une métaphore pour représenter la maladie d’Alzheimer en consultation gériatrique
Authors: Ortiz Caria Alexandra , Fornel Michel de
Published: May 2022

Chef du service de gériatrie d’un hôpital parisien, le Pr. A. a pour habitude de produire un objet de référence commun pour décrire la maladie d’Alzheimer à ses patients en recourant à la description d’une maison dont l’escalier endommagé ne permet pas d’accéder aux pièces de l’étage supérieur, symbolisations de leurs facultés intellectuelles préservées. Le médecin mobilise à cet effet diverses ressources sémio-discursives, qu’il combine principalement avec des gestes iconiques à valeur métaphorique, pour accomplir l’activité descriptive et organiser son tour de parole. Ce sens métaphorique réside dans l’incongruité sémantique partielle observable lors de la performance multimodale entre schématisation conventionnelle des gestes et schématisation de l’expression verbale affiliée. Par cette mise en scène verbale et gestuelle, le gériatre cherche à transmettre et faire partager de façon didactique un savoir médical, tout en laissant le patient libre d’accorder crédit à sa métaphore visant à expliquer la maladie dont il est atteint.
La corruption et son antidote dans les œuvres de Tijan M. Sallah, Tanure Ojaide et Tunde Omobawale
Authors: Mendy Lice John
Published: May 2022

Le présent travail a pour objectif d’analyser combien la corruption, ses causes et ses effets imprègnent l’espace ouest-africain en particulier et l’Afrique en général. Le thème de la corruption n’est certes pas une nouveauté, mais son ampleur se ressent aujourd’hui dans tous les secteurs, et ce jusqu’à nourrir en profondeur la littérature. Nous nous appuierons sur des œuvres de Tijan M. Sallah, Tanure Ojaide et Tunde Omobawale qui condamnent non seulement les États, mais qui prônent aussi implicitement un retour aux valeurs traditionnelles africaines. C’est pourquoi nous considérons ces auteurs comme autant de griots qui explorent leur terre natale et la perçoivent dans ses liens avec les autres territoires. Tunde Omobawale va d’ailleurs plus loin en nous montrant comment la bonne gouvernance pourrait être un antidote à la corruption.
L’utilisation des animaux en sciences : pourquoi et comment ?
Authors: MAGNOL Laetitia , SAGE Magali , VUILLIER Karine , DRUILHE Anne , NADAUD Séverine
Published: May 2022

Pour progresser, la recherche en biologie animale s’appuie sur des données obtenues à partir de prélèvements faits sur des êtres vivants et sur différents modèles complémentaires. Ces modèles miment tout ou partie de l’être vivant étudié et reposent sur la modèlisation informatique (approche in silico), sur l’analyse de molécules en « tubes » et la culture de cellules ou de tissus (in vitro) et sur le recours aux animaux (in vivo). Les modèles in silico et in vitro sont très utilisés mais ne permettent pas, à l’heure actuelle, de reproduire la complexité d’un organisme vivant. L’utilisation des animaux en sciences reste d’actualité, et est menée dans un cadre juridique et éthique qui protège les animaux et exige le respect de leur bien-être. Dans les pages qui suivent, sont présentés le cadre européen actuellement en vigueur et les justifications de l’utilisation des animaux à des fins scientifiques au niveau international et au sein de l’établissement utilisateur d’animaux qu’est l’Université de Limoges.
Sport in Paolo Sorrentino’s Movies
Authors: Bauer Thomas
Published: May 2022

While sport is a popular theme for film directors, it is all too rarely studied by social science researchers. This is all the more true when it is considered as just one of the many narrative or decorative elements of the film and is not at the heart of the story. Such is the case for academic studies related to Italian director Paolo Sorrentino’s work, in which the easily identifiable theme of sport is surprisingly nowhere to be found. Indeed, while reference to the body periodically occurs, most of the work conducted on his feature films focuses on the recurrent themes of politics and the quest for power, loneliness and isolation, the flâneur in post-industrial society, sexism, irony, and of course the mafia. The sporting occurrences (including footballer Antonio Pisapia in L’Uomo in più, Cheyenne’s ping-pong match in This Must Be the Place, as well as Fred Ballinger and Mick Boyle’s alpine treks in Youth, etc.) cannot be missed. Why then does Sorrentino choose to refer to sport: for societal, narrative or nostalgic reasons? These questions and more invite us to identify the “constants” and “variables” of this theme, so as to highlight a strong element of his style.
Aza-SAHA Derivatives are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout
Authors: Steimbach Raphael R. , Herbst-Gervasoni Corey J. , Lechner Severin , Stewart Tracy Murray , Klinke Glynis , Ridinger Johannes , Géraldy Magalie , Tihanyi Gergely , Foley Jackson R. , Uhrig Ulrike , Kuster Bernhard , Poschet Gernot , Casero Robert A. , Médard Guillaume , Oehme Ina , Christianson David W. , Gunkel Nikolas , Miller Aubry K.
Published: May 2022

We report the first well-characterized selective chemical probe for histone deacetylase 10 (HDAC10) with unprecedented selectivity over other HDAC isozymes. HDAC10 deacetylates polyamines and has a distinct substrate specificity, making it unique among the 11 zinc-dependent HDAC hydrolases. Taking inspiration from HDAC10 polyamine substrates, we systematically inserted an amino group (“aza-scan”) into the hexyl linker moiety of the approved drug Vorinostat (SAHA). This one atom replacement (C-->N) transformed SAHA from an unselective pan-HDAC inhibitor into a specific HDAC10 inhibitor. Optimization of the aza-SAHA structure yielded the HDAC10 chemical probe DKFZ-748, with potency and selectivity demonstrated by cellular and biochemical target-engagement, as well as thermal-shift, assays. Co-crystal structures of our aza-SAHA derivatives with HDAC10 provide a structural rationale for potency, and chemoproteomic profiling con-firmed cellular HDAC10-selectivity of DKFZ-748 across the target landscape of HDAC drugs. Treatment of cells with DKFZ-748, followed by quantification of selected polyamines, confirmed for the first time the suspected cellular function of HDAC10 as a polyamine deacetylase. Finally, in a polyamine-limited in vitro tumor model, DKFZ-748 showed dose-dependent growth inhibition of HeLa cells. We expect DKFZ-748 and related probes to enable further studies on the enigmatic biology of HDAC10 and acetylated polyamines in both physiological and pathological settings.
Droperidol as a Potential Inhibitor of Acyl-homoserine Lactone Synthase from A. baumannii: Insights from Virtual Screening, MD Simulations and MM/PBSA Calculations
Authors: Jha Rajat Kumar , Singh Ekampreet , Khan Rameez Jabeer , Kumar Ankit , Jain Monika , Muthukumaran Jayaraman , Singh Amit Kumar
Published: May 2022

A. baumannii belongs to the ESKAPE family of pathogens and is a multi-drug resistant, gram-negative bacteria which follows the anaerobic form of respiration. A. baumannii is known to be the causative agent of hospital-related infections such as pneumonia, meningitis, endocarditis, septicaemia and a plethora of infections such as urinary tract and wound infections found primarily in immunocompromised patients. These attributes of A. baumannii make it a priority pathogen against which potential therapeutic agents need to be developed. A. baumannii employs the formation of a biofilm to insulate its colonies from the outer environment, which allows it to grow under harsh environmental conditions and develop resistance against various drug molecules. Acyl-homoserine lactone synthase (AHLS) is an enzyme involved in the quorum-sensing pathway in A. baumannii, which is responsible for the synthesis of signal molecules known as acyl-homoserine lactones (AHL), which trigger the signalling pathway to regulate the factors involved in biofilm formation and regulation. The current study utilised a homology modeled structure of AHLS to virtually screen it against the ZINC in trial/FDA approved drug molecule library to find a subset of potential lead molecules. These molecules were then filtered based on Lipinski’s, toxicological and ADME properties, binding affinity, and interaction patterns to delineate lead molecules, which were then validated using molecular docking. The identified molecules and a control molecule were subsequently subjected to molecular dynamics simulations to mimic physiological conditions of protein-ligand binding under the influence of a forcefield. The MM/PBSA based binding free energy calculations showed favourable results for Droperidol (-50.02 ± 4.67 kcal/mol) and Cipargamin (-42.29 ± 4.05 kcal/mol). The global and essential dynamics analyses, free energy landscape and dynamical cross-correlation matrix and MM/PBSA based binding free energy suggested Droperidol (ZINC000019796080) and Cipargamin (ZINC000049037032) as potential inhibitors against the acylated-ACP substrate-binding site in AHLS from A. baumannii.
On the prospects of optical cycling in diatomic cations: Effects of transition metals, spin-orbit couplings, and multiple bonds
Authors: Wójcik Paweł , Hudson Eric R. , Krylov Anna I.
Published: May 2022

Molecules with optical cycling centers (OCCs) are highly desirable in the context of fundamental studies as well as applications (e.g., quantum computing) because they can be effectively cooled to very low temperatures by repeated absorption and emission (hence, cycling). Charged species offer additional advantages for experimental control and manipulation. We present a systematic computational study of a series of diatomic radical-cations made of a d-block metal and a p-block ligand, that are isoelectronic (in their valence shell) to the successfully laser-cooled neutral molecules. Using high-level electronic structure methods, we characterize state and transition properties of low-lying electronic states and compute Franck-Condon factors. The computed branching ratios and radiative lifetimes reveal that the electronic transitions analogous to those successfully used in the laser cooling of neutral molecules are less than optimal in the cations. We propose alternative transitions suitable for optical cycling and highlight trends that could assist future designs of OCCs in charged or neutral molecules.
Investigation of Dentists' Willingness to have COVID-19 Vaccine
Authors: GÜMÜŞTAŞ Burak , BİRANT Sinem
Published: May 2022

Objective: The aim of the study is to evaluate the willingness and hesitancy of COVID-19 vaccine among dentists.Materials and Methods: The questionnaire forms prepared for this cross-sectional study were converted into an online questionnaire and sent to dentists. The answers of the dentists who could be reached by this method in Turkey and volunteered to participate in the research were analyzed. Statistical analysis was performed using Chi-Square Test, Kruskall Wallis test and multinomial regression analysis. Statistical significance was determined as p<0.05.Results: A total of 290 dentists participated in the survey. 91.7% of the respondents whose marital status is single agree to be vaccinated, while 2.1% are undecided and 6.2% refuse to be vaccinated. 33.4% of non-working participants agreed to be vaccinated, while 66.7% were undecided. (p<0.05) There is a positive relationship between the participants' having additional income and their acceptance of the vaccine.Conclusions: Our study showed that the acceptance of the COVID-19 vaccine among Turkish dentists is high level. Knowledge about the COVID-19 vaccine should be strengthened to further increase vaccine acceptance rates. Dentists' high acceptance of the COVID-19 vaccine is expected to have a positive impact on population acceptance.
Cerrahi Hemşirelerinin Merhamet Yorgunluğu ile Bakım Davranışları Arasındaki İlişkinin Belirlenmesi
Authors: DIĞIN Figen , KIZILCIK ÖZKAN Zeynep , DÜZGÜN ŞAHİN Ayşe
Published: May 2022

Amaç: Cerrahi hemşirelerinin merhamet yorgunluğu ile bakım davranışları arasındaki ilişkinin belirlenmesidir.Materyal ve Metot: Tanımlayıcı ve kesitsel tipte olan araştırma bir kamu hastanesinin cerrahi birimlerinde çalışan ve araştırmaya katılmaya gönüllü olan 143 hemşirenin katılımıyla gerçekleştirildi. Veri toplamada Hemşire Tanıtım Formu, Merhamet Yorgunluğu Kısa Ölçeği ve Bakım Davranışları Ölçeği-24 kullanıldı. Etki büyüklüğü=0,291, %95 güven düzeyinde ve %80 güç oranı öngörerek G * Power 3.1.9.4 programı ile örnekleme alınması gereken en az kişi sayısı 89 olarak bulundu. Araştırma verileri elektronik anket aracılığıyla çevrim içi olarak toplandı ve toplam 143 hemşireye ulaşıldı. İstatiksel değerlendirmeler IBM SPSS’de (V.22) Spearman Korelasyon analizleri ile gerçekleştirildi. İstatistiksel anlamlılık sınırı p<0,05 olarak kabul edildi.Bulgular: Hemşirelerin yaş ortalaması 28,2±4,4 yıl, %80,4’ü kadın ve %76,2’si lisans mezunu idi. Hemşirelerin Merhamet Yorgunluğu Kısa Ölçeği toplam puan ortalamaları 48,7±20,8 ve Bakım Davranışları Ölçeği-24 toplam puan ortalamaları 5,5±0,3 bulundu. Merhamet Yorgunluğu Kısa Ölçeği toplam puan ortalamaları ile Bakım Davranışları Ölçeği-24 toplam puan ortalamaları bilgi beceri alt boyutu ve saygılı olma alt boyut puan ortalamaları arasında negatif yönlü zayıf bir ilişki belirlendi (p=0,048, p=0,000 ve p=0,000).Sonuç: Cerrahi hemşirelerinin merhamet yorgunluklarının ortalamanın altında ve bakım kalitesi algılarının yüksek düzeyde olduğu görülmektedir. Hemşirelerin merhamet yorgunlukları arttıkça bakım kalitesi algıları azalmaktadır.
Frontiers in Life Science
Authors: G Dr Shobana , L Dr Suvetha , S Dr Revathi , P Sasireka , P Dr Mohana , A Dr Agnes Deepa
Published: May 2022

The Frontiers in Life Science Handbook is a performance-based text intended for use by students of Environmental Toxicology, Conservation Biology, Entomology, Microbiology, and allied sciences, as well as microbiologists and others interested in Life Science. The book's goal is to provide up-to-date information and to explain in detail the routine toxicological methods used in a toxicology laboratory. The Frontiers of Life Science handbook is divided into six chapters. Research Methods are included in each chapter. Each exercise includes in-depth research aspects of the practical, principle, and experimental procedure. The book is lavishly illustrated with black-and-white and colour diagrams.It is necessary to draw on the work of many authorities and seek the advice of experts when compiling a book of this type, and the authors are grateful to all of them. Although every effort has been made to ensure that the book is error-free, errors may occur. We gratefully accept constructive criticism and valuable suggestions from readers for future editions of the book. We also want to thank the publishers who took on the task of publishing the book.
Books
Authors: Roth Herbert , Farmer J. A. , Marsh N. R.
Published: May 2022

Review of Industrial Relations; a Search for Understanding and Introduction to the Law of Employment and Attitudes of New Zealand Workers
Структурные изомеры и колебательный спектр тетрафторзамещенного фталоцианина цинка
Authors: Низовцев А.С.
Published: May 2022

Методами теории функционала плотности рассчитаны структурные параметры и относительные энергии Гиббса четырех тетрафторпроизводных фталоцианина цинка(II) с заместителями в непериферийных положениях. Установлено, что наибольшей термодинамической стабильностью при стандартных условиях обладает наименее симметричный изомер. Показано, что экспериментальный ИК спектр исследуемого соединения содержит вклады от ИК спектров соответствующих изомеров, а также предложен теоретический подход для его моделирования.
Структурные особенности и каталитические свойства двойного оксида AgFeO2 в реакции окисления СО
Authors: Свинцицкий Д.А. , Метальникова В.М. , Черепанова С.В. , Боронин А.И.
Published: May 2022

Проведено исследование структурных особенностей и каталитических свойств двойного оксида серебра и железа AgFeO2 в реакции окисления СО. Образцы двойного оксида получены методами соосаждения и гидротермального синтеза при различной температуре. В интервале температур синтеза от 140 °С до 180 °С формировались хорошо окристаллизованные частицы двойного оксида AgFeO2 со структурой преимущественно политипа 3R (~90 %), а при T = 60—120 °С получены частицы с высокой дисперсностью и развитой дефектной структурой. Показано, что расчетные рентгенограммы для моделей кристаллов делафоссита с микродвойникованием хорошо соответствуют экспериментальным кривым. Образцы двойного оксида AgFeO2 демонстрировали высокую активность в реакции окисления СО, которая возрастала с уменьшением температуры синтеза. Установлено, что наиболее высокая удельная каталитическая активность наблюдалась для высокодисперсных образцов с развитой дефектной структурой. Воздействие реакционной среды в ходе каталитических испытаний приводило к модификации состава поверхности вследствие частичного выхода серебра из структуры делафоссита.
Evaluasi efektivitas tingkat kepatuhan wajib pajak dalam memenuhi kewajiban perpajakannya
Authors: Paso Anisinta , Puspita Wulan Dri
Published: May 2022

This study aims to evaluate the effectiveness of the compliance level of taxpayers (WP) in fulfilling their tax obligations. The object of this research is KPP Pratama Malang Utara as an agency that secures state revenue from the tax sector. Data collection techniques in this study were carried out using literature, interviews, and observation methods, while data analysis in this study was carried out by collecting data, analyzing it, then explaining the findings related to the problems encountered to draw conclusions and suggestions. The results showed that the level of taxpayer compliance in fulfilling their tax obligations related to tax payments and SPT reporting at KPP Pratama Malang Utara, both showed an unstable situation. The effectiveness calculation is not able to prove that the level of effectiveness of tax revenue and annual tax return reporting is increasing. This is caused by non-compliance and ignorance of taxpayers in fulfilling their tax obligations.
Entrenamiento muscular inspiratorio en pacientes con insuficiencia cardíaca: una revisión de revisiones.
Authors: Bizzozero Peroni Bruno , Díaz Goñi Valentina
Published: May 2022

El objetivo de esta revisión fue conocer la influencia del entrenamiento muscular inspiratorio (EMI) sobre la capacidad aeróbica y la fuerza muscular inspiratoria (FMI) en pacientes coninsuficiencia cardíaca(IC). Realizamos una revisión de revisiones sistemáticas en PubMed y Web of Science hasta agosto de 2019. Se identificaron un total de 2053 artículos, de los cuales 4 se seleccionaron para esta revisión. Se utilizó la herramienta ‘Assessmentof Multiple Systematic Reviews 2’ (AMSTAR-2) para evaluar la calidad de los estudios. En los estudios incluidos se examinaron un total de 10 intervenciones diferentes con 250 pacientes (rango edad media= 53-76 años). Todos los estudios presentaron nivel de confianza alto (AMSTAR-2). El EMI presentó mejoras significativassobre la capacidad aeróbica(test de la marcha de 6 minutos: 46.66-71.04 metros; p<0.05 y VO2pico: 2.59-2.65 mL/kg-1/min-1; p<0.01)y la FMI(presión inspiratoria máxima: 16.57-23.36 cmH2O, p<0.05)en comparación al grupo control. Programas de intervención de EMI con una duración de 12 semanas reportaron mayores mejorías sobre la capacidad aeróbica y la FMI en comparación a programas de intervención de menor duración. El EMI es un tratamiento importante y necesario en la rehabilitación cardíaca de pacientes con IC. Son necesarios más estudios que analicen los efectos de diferentes rangos en las características del EMI.
Determination of Buffalo Milk Production Cost: The Case of Iğdır Province
Authors: KARADAŞ Köksal , ÖZGER Ömer
Published: May 2022

Objective: The study aims to determine the production cost of buffalo milk in Iğdır Province. Material and Methods: The questionnaires from 92 water buffalo farms obtained at 2016, determined by simple random sampling method were used. While calculating the milk cost, used the combined cost method was used.Results: At the end of the study, it was determined that there were 3.04 female buffaloes in each farm and a total of 3064 kg of buffalo milk was produced. Fixed costs account for 60% of buffalo milk production costs and variable costs for 40%. While the foreign shepherd's expenses have the highest share in variable costs, the most share is received by family labor wage provisions among fixed costs. It was calculated that the selling price of per kilogram of buffalo milk is 1.67 ,thecostis0.59,thecostis0.59and the net profit is 1.08 $. Conclusion: Buffalo breeders have completed the production period profitably by selling buffalo milk at a price above the cost. It can be suggested to increase the number of buffaloes in the region and continue production.
Van İli Erciş İlçesi Ulupamir Köyünde Yetiştirilen Yerli Atların Bazı Morfolojik Özellikleri
Authors: ALARSLAN Emre , AYGÜN Turgut
Published: May 2022

Amaç: Bu çalışma, Van ili Erciş ilçesi Ulupamir köyünde yetiştirilen yerli atların bazı morfolojik özelliklerini ortaya koymak amacıyla yapılmıştır.Materyal ve Yöntem: Morfolojik özelliklere ilişkin verileri elde etmek için atların çeşitli vücut ölçüleri alınmıştır. Çalışma, Ulupamir köyündeki tüm at yetiştiricilerinin %72’sini temsil eden 32 at yetiştiricisine ait ve toplam at sayısının da %71’ini temsil eden 20 aygır ve 17 kısrak olmak üzere toplam 37 baş at üzerinde yürütülmüştür.Bulgular: Atların cidago yüksekliği (CY), vücut uzunluğu (VU), sağrı yüksekliği (SY), göğüs derinliği (GD), göğüs genişliği (GG), göğüs çevresi (GÇ) ve incik çevresine (IC) ait En-Küçük Kareler ortalamaları sırasıyla 133.97, 136.91, 133.56, 57.16, 34.91, 151.00 ve 17.24 cm olarak bulunmuştur. Yaş gruplarının sağrı yüksekliği ve incik çevresi üzerine etkisi istatistik olarak önemli bulunmuştur (P<0.05). Araştırmada kullanılan atlarda CY ile VU, SY, GG, GÇ ve IC morfolojik özellikleri arasındaki korelasyon katsayıları istatistik olarak önemli bulunmuştur (P<0.05; P<0.01).Sonuç: Araştırmanın yürütüldüğü Ulupamir köyünde geleneksel olarak yapılan at yetiştiriciliğinin Kırgız kültüründe önemli bir yere sahip olmasından dolayı tarihsel süreç içerisinde yetiştiricilerin edindikleri deneyimlere bağlı kalarak yetiştirme işlerini yürüttükleri anlaşılmıştır. Sonuç olarak, Ulupamir köyünde halk elindeki yerli atların bazı morfolojik özellikler bakımından Doğu Anadolu at ırkı ile benzerlik gösterdiği söylenebilir.
Süt Sığırlarında Tırnak Kesimi: Hayvan Refahı ve Verimlilik Üzerine Etkileri
Authors: İZCİ Celal , SULU Kadir
Published: May 2022

Topallık, dünyadaki tüm süt sığırcılığı işletmelerinde en önemli sağlık, verimlilik ve refah sorunlarından biridir. Süt sığırlarında topallıkların %90'dan fazlası ayak hastalıkları ve tırnak bozukluklarına ilişkin şekillenmektedir. Topallığı önlemek ve yönetmek amacıyla en sık önerilen uygulama tırnak kesimidir. Tırnak kesimi uygulanan ineklerin gösterdikleri fizyolojik ve davranışsal tepkiyi belirlemek, bunun verimlilik üzerine etkisini değerlendirmek ve konuyla ilgili bilgi eksikliklerini tanımlamak yapılacak yeni araştırmalara ışık tutması bakımından önemlidir. Bu bağlamda süt sığırlarında gerek tırnak sağlığı gerekse topallık tedavisi amacıyla yapılan koruyucu ve terapötik (tedavi edici) tırnak kesiminin hayvan refahı ve verimliliği üzerindeki etkilerini değerlendirmek faydalı olacaktır. Bu derlemenin amacı; tırnak kesiminin sığırlarda neden olduğu fizyolojik ve davranışsal tepkinin hayvan refahı ve verimliliği üzerindeki etkisinin değerlendirilmesidir.
Manda Yetiştiriciliğinin Ekonomik Yönü Üzerine Bir Analiz: Balıkesir İli Örneği
Authors: SANER Gamze , ENGİNDENİZ Sait , ADANACIOĞLU Hakan , GÜLER Duran , ŞENGÜL Zekiye
Published: May 2022

Amaç: Türkiye’de 2010 yılı sonrasında manda ürünlerinin değerinin anlaşılması ve uygulamaya geçirilen projelerin de etkisiyle manda yetiştiriciliği önem kazanmıştır. Bu çalışmada Balıkesir ilinde Halk Elinde Manda Islahı Projesi kapsamındaki manda işletmelerinin ekonomik yönü ortaya konulmuştur.Materyal ve Yöntem: Araştırmanın verileri Balıkesir ilinde manda sütü üretiminin yoğun olarak yapıldığı Altıeylül ile Gönen ilçelerinde bulunan toplam 102 üreticiden anket yoluyla elde edilmiştir. Araştırma kapsamında manda yetiştiriciliği ile uğraşan işletmelerin özellikleri arasında işletme büyüklüklerine (1-10 baş, 11-20 baş ile 21 baş ve üzeri) göre farklılık olup olmadığı Kruskal-Wallis testi ile istatistiksel olarak test edilmiştir.Bulgular: Araştırmada manda başına bir laktasyonda süt verimi ortalama 1332.89 kg olarak bulunmuştur. Bu miktar 2019 yılı Türkiye ortalamasının (1000.10 kg) oldukça üzerindedir. Büyükbaş hayvan birimi (BBHB) başına günlük toplam yem tüketimi 12.32 kg’dır. İşletmeler ortalamasına göre büyükbaş hayvan birimi başına net kâr 1484.31 TL’dir. Çalışmada küçük ölçekli aile işletmelerinin daha kârlı olduğu, bu işletmelerin elde ettiği sütü katma değerli ürüne çevirerek kendi olanakları doğrultusunda pazarladığı belirlenmiştir.Sonuç: Manda yetiştiriciliğinin ekonomik olarak sürdürülebilir olması için devlet tarafından desteklenmesi ve üreticinin katma değeri yüksek manda ürünlerine yöneltilmesi gerekmektedir. Böylelikle kırsaldan şehirlere göç engellenecek, üreticiler geleneksel manda yetiştirme yöntemlerini daha modern ve teknik koşullarda sürdürme olanağı bulabileceklerdir
THICKNESS OPTIMIZATION OF ORGANIC SOLAR CELL BY OPTICAL AND 1D DRIFT-DIFFUSION ELECTRICAL MODELING
Authors: Hidayat Anjar Taufik
Published: May 2022

Finding the best thickness combination of the active layer and the interlayer of organic solar cells is essential to optimizing and producing an efficient device. In this research, the thickness combination was graphed by two scan steps, i.e., the major scan (50 nm - interval) followed by the minor scan (10 nm - interval). The solar cell device was modeled by optical and 1D drift-diffusion modeling in the gvdm simulation software with P3HT: PCBM as the active layer and three different materials for the hole-selective layer (interlayer). The best power conversion efficiencies were 5.21, 4.14, and 5.22% when PEDOT: PSS, V2O5, and Spiro-OMeTAD were interlayer materials. The effective thickness for every interlayer material is 10 nm, while the effective thickness of the active layer is 220 nm (for PEDOT: PSS and Spiro-OMeTAD devices) and 230 nm (for V2O5 device). As a result, each device gives higher power conversion efficiency than that from the original setting of the software. Furthermore, this study's highest power conversion efficiency was higher than previously reported. These results suggest that scanning a more extensive range of layer thickness combinations is necessary to find the highest power conversion efficiency possible for every organic solar cell device
A Machine Learning Pipeline for Mortality Prediction in the ICU
Authors: Sun Yang , Zhou Yi-Hui
Published: May 2022

ABSTRACT

Mortality risk prediction for patients admitted into the intensive care unit (ICU) is a crucial and challenging task, so that clinicians are able to respond with timely and appropriate clinical intervention. This becomes more urgent under the background of COVID-19 as a global pandemic. In recent years, electronic health records (EHR) have been widely adopted, and have the potential to greatly improve clinical services and diagnostics. However, the large proportion of missing data in EHR poses challenges that may reduce the accuracy of prediction methods. We propose a cohort study that builds a pipeline that extracts ICD-9 codes and laboratory tests from public available electronic ICU databases, and improve the in-hospital mortality prediction accuracy using a combination of neural network missing data imputation approach and decision tree based outcome prediction algorithm. We show the proposed approach achieves a higher area under the ROC curve, ranging from 0.88-0.98, compared with other well-known machine learning methods applied to similar target population. It also offers clinical interpretations through variable selection. Our analysis also shows that mortality prediction for neonates was more challenging than for adults, and that prediction accuracy decreases as patients stayed longer in the ICU.
Kajian Yuridis Badan Bank Tanah dalam Hukum Agraria Indonesia
Authors: Kafrawi  , Rachman Maulana Kafrawi
Published: May 2022

Masalah pengadaan tanah merupakan masalah yang selalu muncul dalam kegiatan-kegiatan pembangunan. Munculnya spekulan tanah yang mengambil keuntungan dalam proyek pembangunan infrastruktur. Pada akhirnya hal tersebut menyebabkan proyek pembangunan menjadi sulit dilaksanakan, dan bahkan gagal atau terbengkalai sama sekali. Oleh karena itu, dalam Undang-Undang Nomor 11 Tahun 2020 Tentang Cipta Kerja, pemerintah membentuk badan bank tanah yang berfungsi sebagai pengelola tanah. Hasil dari penelitian ini adalah Eksistensi badan bank tanah telah ada baik secara konstitusional dalam sistem hukum agraria Indonesia, yakni dalam Pasal 33 Ayat (3) UUD 1945, yang kemudian secara implisit termaktub dalam Pasal 2 ayat (2) UUPA. Badan bank tanah merupakan bentuk dari kewenangan Hak Menguasai Negara atas Tanah (HMN) yang menyelenggarakan fungsi sebagai pengelola tanah (land manager). Pengaturan badan bank tanah dalam Undang-Undang Nomor 11 Tahun 2020 tentang Cipta Kerja menempatkan investasi sebagai prioritas utama, di samping terdapat beberapa tujuan lain, seperti kepentingan umum, kepentingan sosial, kepentingan pembangunan nasional, pemerataan ekonomi, konsolidasi lahan serta reforma agraria. Hal ini berbeda dengan konsep bank tanah di beberapa negara lain, seperti Belanda, Swedia dan Amerika Serikat yang secara garis besar terfokus pada kesejahteraan. Penyelenggaraan bank tanah di negara-negara tersebut sangatlah tergantung pada kebutuhan masyarakat di suatu wilayah tertentu, dikarenakan hal itulah yang akan menentukan tujuan dan fokus dari bank tanah secara spesifik.
100 anni dopo l’insulina: cosa ancora non sappiamo della sua secrezione nel diabete di tipo 2
Authors: Di Giuseppe Gianfranco , Mezza Teresa , Cinti Francesca , Giaccari Andrea
Published: May 2022

β-cell dysfunction is a well-known feature of type 2 diabetes mellitus. In particular, it has been shown that defects in 1st phase insulin secretion play a fundamental role in the natural history of the disease. In this review, we highlight the clinical relevance of 1st phase impairment, focusing on its connection with post meal hyperglycemia and diabetic complications; we further evaluate possible therapeutic strategies aimed at improving β-cell secretory machinery and providing a durable control of the disease. In conclusion, we discuss the clinical relevance of C-Peptide sampling in detecting secretory defects.
L’insulina alla luce delle nuove linee guida italiane per il trattamento del diabete di tipo 2: quando, in chi e perché?
Authors: Monami Matteo
Published: May 2022

Aim: this editorial is aimed at providing a reference for the insulin treatment of type 2 diabetes in adults. Methods and results: the present paper revised the recently published Italian guidelines for the treatment of type 2 diabetes (outpatients), either in primary care or specialist referral. The guideline has been developed following the methods described in the Manual of the National Guideline System (http://www.snlg-iss.it) by a panel nominated by the Società Italiana di Diabetologia (SID) and Associazione Medici Diabetologi (AMD). Prior cardiovascular events, heart failure, hypoglycemic risk, and other conditions have been considered as factors capable of modifying treatment strategies. The following areas have been assessed: 1) position of the insulin therapy in the new algorithms; 2) type of formulations (insulin analogues or human insulin); 3) use of insulin infusion pumps. Conclusions: insulin should be used only as a second/thirdline therapy due to its lower efficacy on long-term HbA1c, higher risk of hypoglycemia, and neutral effects on cardiorenal outcomes. Human insulin formulations should be avoided for safety concerns (higher hypoglycemic risk) with no preference among different insulin analogues. Insulin pumps are not recommended for the treatment of type 2 diabetes.
industria minera en Latinoamérica
Authors: Horta-Gaviria Carolina-Maria , García-Rodríguez Margarita-Marcela
Published: May 2022

Objetivo: a fines de la última década del siglo XX, América Latina fue testigo de la llegada de un intenso flujo de inversión extranjera para actividades de exploración y minería. Este artículo comprende el impacto de los extractivismos en algunos de los conflictos de América Latina. Metodología: la investigación utilizó el método comparativo de la ciencia política para analizar datos cuantitativos y cualitativos, gubernamentales y no gubernamentales, para la comprensión de los conflictos socio ambientales producidos por la minería; especialmente aurífera en Amrica Latina. Los resultados son geo-referenciados como una manera de representar la intensidad de los conflictos en el espacio geográfico. Resultados: la carrera de los actores empresariales, estatales y hegemónicos por ser dueños y señores de la biomasa natural y las reservas minerales ha revelado los intereses de controlar no solo la forma en que los Estados administran, sino también la naturaleza misma. Conclusiones: se encuentra que grandes multinacionales están impactando negativamente en los conflictos sociales, económicos y políticos de América del Sur y del Caribe. La licencia social de operación entregada a las multinacionales no logra reducir los conflictos en los territorios. Las políticas gubernamentales, pese a reconocer los derechos sociales y ambientales, siguen dando vía libre a la explotación de la naturaleza: desconociendo los objetivos de desarrollo sostenible, favoreciendo la acumulación de capitales de países del norte mediante la desposesión de la riqueza ambiental y social de los países del sur de América y del Caribe.
Protección jurídica de los adultos mayores en Risaralda (2016-2018) desde la perspectiva del Estado social de Derecho
Authors: Hurtado Maya Alexandra , Heredia Rios Elkin Andres
Published: May 2022

El presente artículo de investigación tiene como objetivo principal analizar la efectividad que ha tenido la normativa y jurisprudencia para la protección del mínimo vital de los adultos mayores en el departamento de Risaralda durante el período 2016-2018. El envejecimiento es un proceso natural del ser humano en el que ocurre un deterioro de las capacidades psicomotoras e intersubjetivas que, en términos de calidad de vida y dignidad, genera una condición de vulnerabilidad y por ende de urgencia de cuidado y atención. Esta realidad hace necesario evidenciar el cumplimiento de objetivos por parte del Estado colombiano en torno a este reto. En la medida en que es el garante de los derechos relacionados con la protección e inclusión de los adultos mayores como grupo especial de una sociedad que se autodefine según los principios del Estado social de Derecho y de una justicia redistributiva, el Estado debe propender por la garantía del mínimo vital de esta población. Objetivo: determinar el nivel de protección al mínimo vital de los adultos mayores como sujetos de especial protección constitucional frente a la política pública para el envejecimiento y de los adultos mayores adscritos a los centros de atención institucional públicos en el departamento de Risaralda. Metodología: el enfoque seleccionado fue el socio-jurídico con método mixto. Las técnicas e instrumentos de recolección de información se aplicaron a partir del análisis y revisión de fuentes documentales de la norma y jurisprudencias. Las categorías iniciales planteadas son “mínimo vital”, “derechos fundamentales” y “justicia social”. Resultados: se evidenció durante toda la aplicación metodológica que, aunque en la legislación se encuentra plasmada toda una regulación de normativa en protección al mínimo vital y los derechos de dicha población, no es evidente su buen cuidado, pues las diferentes estadísticas muestran que los adultos mayores mejor protegidos y con una buena calidad de vida son aquellos que hacen parte de hogares privados. Conclusiones: no hay una cobertura a la garantía del mínimo vital para los abuelos que se encuentran en condición de vulnerabilidad en hogares públicos, ya que se establecen una serie de requisitos legales y procedimentales para el acceso a las ayudas gubernamentales, y la mayoría no cumplen con dichos parámetros requeridos, lo que de alguna manera evidencia una afectación a los principios y derechos constitucionales por parte de dicha función estatal.
Nutraceutical Potential of Sweetened chips Prepared by Gluten-Free Composite Flour
Authors: Chauhan Ekta Singh
Published: May 2022

Gluten free composite flour based chips was evaluated in this study for their nutritional, phytochemical and antioxidant properties of all ratios. The composite flour is made up of the mix of proso millet flour (PF), adzuki bean flour (AF) and basil seeds flour (BF). The composite flour is prepared in three ratios that are, A being (PF:AF:BF=50:45:5), B being (PF:AF:BF=60:35:5) and C being (PF:AF:BF=70:25:5) respectively. The macronutrients such as moisture, ash, fat, fiber, protein and carbohydrate were analyzed along with the assessment of micronutrients calcium, iron, phosphorus and zinc. The result of macronutrient and micronutrient of C ratio were moisture (6.21±0.2), ash (3.9±0.0), protein (12.0±0.0), fat (9.0±0.0), fiber (4.2±0.1) and carbohydrate (69.5±0.1g/100g) respectively.
Pengembangan E-LKPD Pembelajaran Tematik Berbasis High Order Thinking Skills (HOTS) untuk Siswa Kelas Rendah Sekolah Dasar
Authors: Rahayu Sri , Ladamay Iskandar , Susanti Romia Hari , Wiyono Bambang Budi , Vindya Mela
Published: May 2022

Penggunaan Lembar Kerja Peserta Didik (LKPD) yang ada saat ini kurang menuntut siswa berpikir kritis, kurang menarik, serta membutuhkan biaya lebih. Untuk mengatasi permasalahan tersebut perlu dilakukan pengembangan terhadap media pembelajaran LKPD. Tujuan penelitian ini yaitu untuk mengembangkan produk Elektronik Lembar Kerja Peserta Didik (E-LKPD) Pembelajaran Tematik Berbasis High Order Thinking Skills (HOTS) untuk Siswa Kelas Rendah Sekolah Dasar. Metode penelitian menggunakan R&D dengan model penelitian ADDIE. Produk yang telah dikembangkan dilakukan uji validitas melalui ahli media, ahli materi, ahli bahasa, uji kepraktisan, dan uji kemenarikan produk dengan perolehan nilai 90% oleh ahli media, 95% oleh ahli materi, 93% oleh ahli bahasa, dan 92% oleh praktisi. Pengumpulan data menggunakan angket penilaian dan angket respon siswa. Hasil penelitian menunjukkan bahwa produk E-LKPD Pembelajaran Tematik berbasis HOTS sangat baik untuk digunakan.
Analisis Kebutuhan Inovasi Model Pembelajaran Bauran Moda Webinar bagi Mahasiswa Berkebutuhan Khusus Tunadaksa dengan Alat Bantu Mobilitas (Model Hybrid Webidaksa)
Authors: Widyasari Widyasari , Adri Helmia Tasti , Hasnin Hanrezi Dhania , Gaffar Awaludin Abdul , Rasmitadila Radmitadila , Aliyyah Rusi Rusmiati , Lathifah Zahra Khusnul , Ariah Ariah
Published: May 2022

Berdasar pada amanat Undang-Undang yang menyatakan bahwa setiap warga negara berhak memperoleh pendidikan yang baik, maka seyogyanya layanan pendidikan harus mampu memfasilitasi seluruh warga negara terlepas dari bagaimana kondisinya apakah dalam kondisi fisik yang sempurna ataupun memiliki kekhususan seperti tunadaksa.  Berkenaan dengan kekhususan tersebut, layanan pendidikan perlu didesain sedemikian rupa agar tepat guna bagi mahasiswa berkebutuhan khusus. Berlatar hal tersebut, penelitian ini mengarah pada desain inovasi model pembelajaran melalui kegiatan analisis kebutuhan. Analisis kebutuhan tersebut merujuk pada pengembangan model pembelajaran bagi mahasiswa tunadaksa yang bertujuan untuk memperoleh model pembelajaran yang tepat baik pada saat pandemi covid-19 seperti saat ini maupun pasca pandemi.  Penelitian ini dilakukan dengan metode survey kepada mahasiswa tunadaksa, dosen pengampu dan pihak fakultas dimana mahasiswa tunadaksa belajar. Pengumpulan data dilakukan dengan cara wawancara, observasi dan penyebaran angket. Hasil penelitian menunjukkan bahwa perlu adanya modifikasi model pembelajaran secara bauran dengan webinar bagi mahasiswa tunadaksa atau disingkat Hybrid Webidaksa yang mencakup modifikasi perencanaan, proses, dan evaluasi pembelajaran.
Pendidikan Karakter Berbasis Kearifan Lokal Tradisi Masyarakat Melayu Perbatasan Pada Siswa Sekolah Dasar
Authors: Syamsijulianto Tri , Rahman Rahman , Sari Mia Zultrianti , Ratumanan Stelie D , Solehun Solehun
Published: May 2022

Masyarakat Melayu perbatasan Entikong memiliki kearifan lokal yang kaya akan nilai dan tradisi. Namun sayangnya ragam nilai tersebut belum dikembangkan dalam penanaman pendidikan karakter di Sekolah Dasar yang kemudian melatari penelitian ini. Tujuan penelitian yakni untuk mengungkapkan urgensi pendidikan karakter yang berbasis pada nilai kearifan lokal masyarakat Melayu perbatasan Entikong pada siswa di Sekolah Dasar. Studi literatur digunakan sebagai metode penelitian yang mengkaji beragam literatur relevan dengan fokus dan tujuan penelitian. Teknik pengumpul data melalui kegiatan mengumpulkan data, memeriksa perolehan data, mengorganisasi keseluruhan data yang diperoleh dan menganalisis data. Analisis konten digunakan sebagai teknik analisis data penelitian. Hasil penelitian menemukan bahwa religius, mandiri , bertanggung jawab, peduli sosial dan gemar membaca merupakan karakter yang berdasar pada nilai kearifan lokal masyarakat yang perlu diimplementasikan dalam pendidikan karakter pada siswa di Sekolah Dasar. Implementasi pendidikan karakter yang berbasis kearifan lokal masyarakat Melayu perbatasan akan membentuk pribadi peserta didik yang selaras dengan nilai yang dianut masyarakat.
WAQF MANAGER (NAZIR) COACHING AND COMPETENCE IN THE DEVELOPMENT OF PRODUCTIVE WAQF
Authors: Munawar Wildan , Pangestu R Ali , Qomaruddin S
Published: May 2022

The development of productive waqf cannot be separated from the competent role of nazir in managing waqf. One of the efforts to improve Nazir's competence is through coaching. This study aims to determine the effect of coaching on increasing nazir's competence to develop productive waqf in Bogor Regency. The research method uses quantitative research with data collection techniques to distribute questionnaires. Data collection was based on a purposive sampling technique for nazir who had received coaching from the Indonesian Waqf Board and the Ministry of Religion, Bogor Regency. The data analysis technique uses Partial Least Square with the help of the Smart PLS 3 application to verify and confirm the coaching that has been done. The results showed that coaching had a positive and significant effect on increasing nazir's competence in developing productive waqf. The increasing competence of Nazir in the development of productive waqf is not enough just to have knowledge and understanding of the science of fiqh alone but must be equipped with competence in business management and entrepreneurship. So that the carried out must be more on the management and development of business-oriented waqf assets.
PENGGUNAAN AKTIVATOR STARDEC TERHADAP KUALITAS KOMPOS BERBAHAN DASAR PELEPAHSAWIT DAN FESES SAPI
Authors: Alfarezy Muhammad , Syafria Hardi syafria , Adriani Adriani
Published: May 2022

Penelitian ini memiliki tujuan agar mengetahui pengaruh dari penambahan aktivator Stardec kepada kualitas kompos yang mengunakan bahan dasar pelepah sawit dan feses sapi. Penelitian ini dilaksanakan selama ±1 bulan pengomposan di laboraturium budidaya ternak dan hijauan Fakultas peternakan Universitas Jambi dan Laboratorium Ilmu Tanah Fakultas Pertanian UNAND. Penelitian yang dilaksanakan ini menggunakan Rancangan Acak Lengkap (RAL) yang terdiri dari 4 perlakuan serta 5 ulangan. Bahan yang digunakan yaitu pelepah sawit 70% + feses sai 25% + urea 1% + dedak 4%, dengan penggunaan stardek A0 0%, A1 0,5%, A2 1% dan A3 1,5%. Peubah yang diamati yaitu pH, dan unsur yang terkandung didalamnya yaitu (karbon, nitrogen, fosfor, kalium, serta rasio C/N). dari penelitian yang telah dilakukan menunjukkan pH (6-7). Hasil analisis statistic menunjukkan bahwa penambahan Stardec berpengaruh sangat nyata (P<0,01) terhadap karbon, fosfor dan kalium. Berpengaruh tidak nyata (P>0,05) kepada nitrogen dan rasio C/N. Berdasarkan hasil penelitian diperoleh hasil terbaik dari kandungan yang terdapat pada kompos seperti (C,N,P,K dan rasio C/N) dan pH yaitu penambahan Stardec 1,5%.