bluuebunny/crossref_metadata_2025 huggingface dataset:
CIRURGIA ROBÓTICA VERSUS CIRURGIA LAPAROSCÓPICA NA PROSTATECTOMIA
Authors: Santana Fonseca Marina , Ferracioli Alvarenga Gabriel Henrique , Costa Paes Gonçalves Julio , Tanaka de Carvalho Freitas Larissa , Mendonça Rocha Carollayne
Published: April 2024

Introdução: O câncer de próstata é uma das formas mais comuns de câncer entre os homens, e sua incidência aumenta com a idade. A cirurgia robótica e a videolaparoscópica são técnicas minimamente invasivas utilizadas na prostatectomia para remover a próstata em pacientes com câncer de próstata localizado. Objetivos: identificar qual das técnicas é mais eficaz e qual delas garante maior benefício ao paciente. Materiais e métodos: Trata-se de uma revisão integrativa, em que a questão norteadora foi “A prostatectomia radical assistida por robô é superior à prostatectomia radical videolaparoscópica?”. A busca pelos artigos ocorreu nas principais bases de dados (PubMed e Scielo) a partir dos termos “difference", "robotic", "laparoscopic", "surgery" e "prostatectomy” combinados entre si por operadores booleanos. Resultados e discussão: Nas últimas décadas, a prostatectomia radical assistida por robô (PRAR) ganhou ampla aceitação na prática cirúrgica urológica. Esta técnica visa alcançar menos morbidade perioperatória, menos sangramento intraoperatório e tempo de recuperação mais rápido. As principais vantagens processuais do uso do sistema robótico são a destreza aprimorada, sua precisão, imagem tridimensional e seu design ergonômico para cirurgiões. Conclusão: A superioridade da prostatectomia radical assistida por robótica sobre a prostatectomia radical laparoscópica continua controversa. Embora a PRAR tenha sido conhecida por ter muitas vantagens em termos de resultados funcionais e oncológicos, o custo do material médico, o custo total de hospitalização e as despesas pessoais foram maiores.
Nuevos Aportes sobre el Tratamiento Quirúrgico del Dolor, Ansiedad y Agitación en el Caso Médico de Eva Duarte de Perón. Neurocirugía Funcional Antálgica en 1952
Authors: Nijensohn Daniel E. , Savastano Luis E. , Kaplan Alberto D. , Laws Jr. Edward R. , Cremaschi Fabián
Published: April 2024

Los detalles de la enfermedad final, tratamiento y muerte de Eva Perón, acaecida en 1952, han permanecido cubiertos por un velo de misterio durante muchos años. A partir de la década de los noventa surgieron diversos testimonios que intentaron esclarecer la etapa final de su vida. En febrero del presente la revista World Neurosurgery (Elsevier©) aceptó publicar nuestro trabajo «Recent evidences of prefrontal lobotomy in the last months of the illness of Eva Perón» («Evidencias recientes de una lobotomía prefrontal en los últimos meses de la enfermedad de Eva Perón»). Esta investigación presenta las declaraciones de George Udvarhelyi, neurocirujano húngaro residente en Argentina entre 1948 y 1953 y que estuvo muy próximo al entorno de Ramón Carrillo (también neurocirujano y ministro de Salud Pública del presidente Juan Domingo Perón). Udvarhelyi declaró haber participado en una lobotomía prefrontal realizada a Eva Perón antes de su muerte para aliviarle el dolor y controlar la agitación y ansiedad en sus últimos meses de vida. Nuestra investigación revela que posiblemente el neurocirujano James L. Poppen, de la Clínica Lahey, Boston (Massachusetts, EE. UU.) fue quien realizó este procedimiento. A partir de la revelación del Dr. Udvarhelyi el presente trabajo contextualiza sus afirmaciones a la luz de las entonces modernas prácticas médicas y neuroquirúrgicas instauradas en la Argentina de mediados del siglo XX y presenta algunas evidencias que dan crédito a tales declaraciones. Nuestro propósito es contribuir a esclarecer el capítulo final de la vida de Eva Perón y ofrecer un punto de vista alternativo a la historia oficial de aquella época. A partir de este caso médico podemos aprender que la enfermedad y el tratamiento de personas en el poder frecuentemente son mantenidos en secreto, pero que eventualmente la verdad puede salir a la luz usando métodos científicos, sin preconcepciones ni conflictos de intereses. Asimismo, hemos tratado de entender el momento y el lugar en donde ocurrieron los sucesos, ilustrando la existencia de modas terapéuticas y la lenta pero segura evolución de la ciencia médica y quirúrgica en búsqueda de alivio y cura.
Un Método Rápido para Localizar el Núcleo Subtalámico con la Tomografía Computarizada
Authors: Zurita-Cueva Boris , Villamar Fidel , Velásquez-Tapia Jaime , Peña-Gaibor Andrés
Published: April 2024

Se describe un método rápido y fácil para encontrar el núcleo subtálamico mediante las imágenes estereotáxicas de la tomografía computarizada (TC). Consiste en la identificación visual del núcleo subtalámico en el corte axial a 4 milímetros por debajo de la línea intercomisural CA-CP (CA, comisura anterior; CP, comisura posterior) al reconocer varias estructuras anatómicas típicas del corte, con la ayuda del atlas de Talairach. A este nivel, el extremo posterior del tercer ventrículo está situado a 2-3 mm por detrás del punto medio intercomisural; a 12 mm por fuera de este punto se sitúa la división somatomotora del núcleo subtalámico, en la mayoría de los casos.
Peran Humas BNNK Surakarta Dalam Mencegah Penyalahgunaan Narkotika melalui Unggahan Informasi dan Edukasi di Media Sosial Instagram
Authors: Septi Ardya , Wisudawanto Rahmat , Ningsih Rahayu Putri Sofia
Published: April 2024

Humas BNNK Surakarta mulai memanfaatkanInstagram untuk menyampaikan informasi dan edukasiterkait dengan berbagai upaya sosialisasi pencegahanpemberantasan peredaran gelap narkotika (P4GN). Penelitian ini bertujuan peran humas badan narkotikanasional kota surakarta dalam mencegahpenyalahgunaan narkotika melalui unggahan informasidan edukasi di media sosial instagram. Penelitian inimerupakan penelitian deskriptif. Teknik analisis data yang digunakan dalam penelitian ini adalah teknikanalisis data kualitatif model Interaktif. Hasil penelitian menunjukan bahwa humas BNNK Surakarta menerapkan 4 peran humas, yaitu communicator, relationship, back up management, dan corporate image
Identification of CRISPR/Cas12a (Cpf1) guideRNA Sequence Targeting the Mitochondrial DNA D-loop Region in Wild Pig (Sus scrofa) Through Homology Difference and Mismatch Analysis
Authors: Zein Muhammad Ihda Hamlu Liwaissunati , Hardianto Ari , Irkham Irkham , Hartati Yeni Wahyuni
Published: April 2024

CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat) or CRISPR-associated (Cas) System has become a major gene editing tool. Gene editing with CRISPR requires the Cas protein and the corresponding guide RNA (gRNA). However, low cleavage efficiency and off-target effects can impede the application of the CRISPR/Cas system. Therefore, the determination of specific gRNAs is essential. In biosensor applications, CRISPR/Cas12a can enhance specificity and sensitivity in identifying target genes due to the trans-cleavage activity of Cas12a (Cpf1). The mtDNA D-loop sequence is the most variable part of mtDNA, making it suitable for distinguishing between species. Consequently, the objective of this study was to determine the gRNA sequence of the D-loop of wild pig mtDNA in silico. Candidate gRNAs were predicted using the Benchling application with the assistance of the GenBank database. The gRNA candidates were subsequently subjected to a homology difference analysis using BLAST nucleotide and a mismatch test using Jalview. Among several candidates, candidate 1 was selected as the best option, with an Off-target value of 99.8. The homology difference analysis against competitors and the mismatch test against the Sus genus resulted in high E-values and high percentage values, respectively. This suggests that the candidate will not recognize other species but can detect members of the Sus scrofa species. These gRNA candidates can be selectively and sensitively applied to biosensors for the detection of meat adulteration.
HIGHLIGHTS  

The D-loop exhibits high variability, make it useful for distinguishing between species
gRNA as an enabler of CRISPR/Cas12a to identify the target and initiate cleavage activity
The candidate 1 was selected with the sequence 5'-GAT TGT CGT GCC GGA TCA TGA GTT-3'
The application of this strategy is aimed at determining the halal status of food products
The application will encompass both quantitative and qualitative aspects

GRAPHICAL ABSTRACT
Purification of IgY Anti-SARS-CoV-2-Chicken Nucleocapsid and Elimination of Its Low-temperature Storage-induced Aggregates
Authors: Idar Idar , Yusuf Muhammad , Anshori Jamaludin Al , Subroto Toto
Published: April 2024

Even though the COVID-19 pandemic has ended, the virus is still circulating. It is important to detect it, as its symptoms are similar to other endemic diseases, e.g. dengue fever. Detection can be done using birds’ specific immunoglobulin Y, IgY Anti-SARS-CoV-2-Chicken Nucleocapsid (IgY anti-N), obtained by immunising chickens with the SARS CoV2 nucleocapsid protein. However, IgY purification requires further research, as commonly used ligands are unsuitable. Another common problem with IgY anti-N is aggregation, even when stored at low temperatures. Thus, this research aims to purify IgY anti-N and eliminate low-temperature storage-induced aggregates. In this study, polyethene glycol (PEG) was used for delipidation. The resulting IgY was divided into 2 parts, one of which was stored at 4 °C and purified within the next 1 or 2 days (labelled as IgY 4 °C), while the other was stored at −20 °C and purified within a period of 1 or 2 years (labelled as IgY −20 °C). The next step involved purifying both samples using hydrophobic chromatography and sequential anion exchange. Peaks resulting from the hydrophobic column were analyzed using High-Performance Liquid Chromatography (HPLC) and Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis (SDS-PAGE). Another purification result was analysed using PAGE. The migration of each separation step result was observed using native, denaturing and non-reducing PAGE. The study showed, qualitatively, that using two-step chromatographic techniques, hydrophobic interaction and ion exchange chromatography significantly increased the purity of IgY during purification. Additionally, the results demonstrated that hydrophobic chromatography purifies IgY and removes aggregates that may arise from storage. Moreover, similar to immunoglobulin G, IgY anti-N was found to have an uncommon migration in native PAGE compared to other proteins.
HIGHLIGHTS  

PEG precipitation for delipidation of egg yolk containing IgY
Two-step chromatographic method for IgY purification: hydrophobic interaction and ion exchange
Hydrophobic interaction chromatography can purify and also remove the aggregate of the IgY sample
Native PAGE cannot be used to calculate antibody molecular weight

GRAPHICAL ABSTRACT
Creche e pré-escola: a questão da obrigatoriedade nas produções acadêmicas
Authors: Cristina Tavares Mara , Amaral Cláudia Tavares do , Abadia da Silva Altina
Published: April 2024

Este artigo é uma revisão sistemática que aborda a importância da creche como etapa fundamental da Educação Infantil no Brasil, com destaque para a problemática da obrigatoriedade apenas para a pré-escola. O objetivo geral foi, portanto, analisar a importância da creche e os impactos da obrigatoriedade da pré-escola na Educação Infantil. Os objetivos específicos foram verificar a contribuição da creche na formação educacional e analisar os impactos socioeconômicos, educacionais e culturais da obrigatoriedade da pré-escola. A falta de acesso à creche, as desigualdades socioeconômicas, a formação inadequada dos professores, a falta de investimento em infraestrutura e as dificuldades de articulação entre as etapas foram alguns dos problemas levantados na produção acadêmica após a LDB de 1996. A análise dessa temática pode auxiliar na formulação de políticas públicas mais eficazes e na promoção de uma educação de qualidade desde a primeira infância.
Trajetória de vida antes e após o ingresso na universidade: história oral de estudantes internacionais
Authors: Fecchio Carolina Amadeu , Costa Sara Eleotério , Leão Rego Renato , Cassandre Márcio Pascoal , Sanguino Gabriel Zanin , Barreto Mayckel da Silva
Published: April 2024

Estudantes internacionais, geralmente, vivenciam enfrentamentos ao estarem inseridos em um modelo educacional e país distintos daqueles de origem. O objetivo desse estudo foi compreender a trajetória de vida de estudantes internacionais antes e após o ingresso em uma universidade pública brasileira. A história oral constitui o referencial teórico para a interpretação dos dados. Participaram 15 estudantes internacionais de uma universidade pública no sul do Brasil, que tinham habilidade de se comunicar em língua portuguesa. A coleta de dados ocorreu entre janeiro e março de 2023, por meio de entrevistas semiestruturadas, que foram gravadas, transcritas na íntegra e analisadas de acordo com a Análise de Conteúdo, modalidade temática. Emergiram três categorias: “Enfrentando dificuldades no país de acolhida”; “Aspectos facilitadores para o enfrentamento das dificuldades no país de acolhida” e “Reconhecendo o passado e pensando no futuro”. Espera-se que estes resultados possam subsidiar a elaboração de políticas institucionais locais que fortaleçam o acolhimento e a integração do estudante internacional, bem como fomentar discussões mais amplas que permitam gestores da internacionalização universitária reconhecer as histórias de vida dos estudantes internacionais e assim, de forma empática, desenvolver estratégias que permitam criar uma cultura de acolhimento longitudinal a esta parcela de estudantes nas universidades brasileiras.
Movie Recommendation System using RNN Approach
Authors: Miss Gayatri Anarase  R  , Kaduskar Priya R  , Kalangade Prasad B
Published: April 2024

The problem of information overload has been made worse by the quick advancement of information technology and the quick expansion of the Internet. In response to this issue, recommender systems have developed, assisting users in finding relevant material. The study of personalized recommendation services has seen a change in focus as a result of the complexity of the social setting. We present a novel recommendation approach based on social network recurrent neural network in order to address the sparsity problem of recommender systems while enhancing their accuracy and diversity in complicated scenarios. Using this approach, we group users and take a number of intricate criteria into account.
Online Voting System using Blockchain
Authors: Prof. Mundhe Bhalchandra B  , Rutuja Devidas Kadam  , Suvarna Bansi Bhosale  , Maheshwari Udaykumar Pisal Patil  , Shaila Sakharam Bhor
Published: April 2024

Blockchain technology has been presented as a support for trust needs between transactions in electronic information systems. Its successful use in cryptocurrencies has allowed it to explore its capabilities in commercial, industrial, and service systems, backed by the operational alternatives offered by Ethereum Smart Contracts and the cryptographic security of public and private key. These keys are used as a way to make online transactions anonymously, with the guarantee offered by the Blockchain network that they are executed safely. With the above in mind, this concept can be extended to the electoral processes, thus allowing its application in electronic voting systems, especially when the protocols currently used lack the trust factor between the different social actors. This document presents a proof of concept in which Blockchain and other technologies are applied, to allow interaction as an electronic voting system for the election of unique candidates. This has been achieved through the specification of an architecture designed especially for electoral processes, from which it is implemented and a simulation is carried out in order to obtain data that generates value, when evaluating Blockchain technology as an alternative to current voting systems
Online Complaint Management System
Authors: Ms. Aarya Mahesh Dulange  , Ms. Nandini Dhananjay Awate  , Ms. Pooja Shivanand Kesegaon  , Ms. Rutuja Suryakant Alegaon  , Ms. Shrutika Revansidh Date  , Ms. Durva Anand Goyal  , Mr. Sagar Somayya Hiremath
Published: April 2024

The online complaint management system is an online platform designed to streamline the process of filling complaints with police department. This project creates an efficient and user-friendly interface for citizens. By providing a centralized system for complaint management.
It’s an online way of solving the problems encountered by the person by time saving. The purpose of developing centralized complainant management system is that we can easily trace the complaint and resolve it and this process is time saving because of it save lots of time by avoiding the actual presence of particular person. complaint resolving through centralized system help us to access the information from user remote location and it is very easy to monitor the overall process. The user or who registered particular complaint they are easy to check and monitor that whether it is resolved , pending etc
Securing the Next Wave: A Comprehensive Review of 5G System Security
Authors: More Meghana Laxman  , Prof. Sapike N. S.
Published: April 2024

This review paper delves into 5G system security, examining various research papers encompassing various technologies. Through an extensive analysis, explore the multifaceted landscape of 5G security, including but not limited to authentication protocols, encryption mechanisms, threat detection, and mitigation strategies. By synthesizing insights from diverse sources, this paper provides a comprehensive understanding of the current state of 5G security, highlighting both challenges and advancements. The findings presented herein aim to contribute to the ongoing discourse on fortifying the security posture of 5G networks, which is crucial for fostering trust and reliability in the burgeoning era of ultra-fast connectivity.
Shop Inventory
Authors: Mr. D. B. Patil  , Mr. P. S. Mane  , Mr. P. A. Patil  , Mr. A. R. Gawade  , Mr. A. R. Gawade  , Mr. P. S. Durgawale
Published: April 2024

This report delves into the design and implementation of an shop inventory (SI) tailored to meet the dynamic needs of modern businesses. The SI serves as a crucial tool for businesses to efficiently monitor, track, and manage their inventory, optimizing operations and enhancing overall productivity. Key features of the SI include real-time inventory tracking, automated stock replenishment, customizable reporting functionalities, and integration with other business systems. The report outlines the system architecture,
database design, user interface, and functionalities, highlighting the benefits and potential challenges of implementing such a system. Additionally, it discusses the importance of data security measures and scalability to accommodate future business growth.
Evidence for a constituent order boost in structural priming
Authors: Jacob Gunnar , Katsika Kalliopi , Family Neiloufar , Kholodova Alina , Allen Shanley E.M.
Published: April 2024

The study investigates the role of constituent order in structural priming. We report the results from a PO/DO priming experiment in German, in which we experimentally manipulated verb position in primes and targets. Significant structural priming effects occurred irrespective of whether verb position was the same in prime and target or not. However, additional similarity in constituent order was able to boost structural priming effects, with significantly stronger priming when the verb occurred in the same position in prime and target. We argue that existing one-stage and two-stage accounts of formulation struggle to account for the entire data pattern and propose an alternative account of formulation which can explain our results.
Dutch speakers take referent predictability into account, irrespective of addressee presence
Authors: Vogels Jorrig
Published: April 2024

Language comprehension involves continuously making predictions about what will be mentioned next. If speakers take these predictions into account, one would expect that they try to be extra clear (e.g., by saying “the girl with the big earrings”) when they are going to say something less predictable. Conversely, speakers do not need to be as clear when the listener already expects the thing that they are about to mention, and can therefore suffice with a pronoun such as she. Previous research testing this hypothesis has found mixed results, with some studies finding that the referent’s predictability in discourse affects pronoun use and others finding that it does not. One explanation might be that speakers are more likely to take predictability into account when there is a co-present addressee who is predicting the next referent. To test this possibility, I conducted a language production experiment in which participants produced spoken continuations of narrative fragments. The fragments were accompanied by pictures that made clear how the story continued. Half of the participants performed the task without anyone else being present, while the other half told the stories to another person, who had to pick out the correct picture. Referent predictability was varied by manipulating the coherence relation in the narrative context. In addition, I calculated a surprisal score for each character in each narrative, as a more direct measure of its predictability. The results showed that with higher predictability, speakers were indeed more likely to use a pronoun than a definite NP to refer to the target character in their continuations. However, it did not matter whether the speaker was telling the stories to a co-present addressee or not. The results are discussed in light of accounts that distinguish between taking the perspective of a specific and that of a hypothetical listener.
Strategi Pengembangan Pariwisata Pesisir Berdasarkan Potensi (Studi Kasus: Pantai Kuala Raja Kabupaten Bireuen)
Authors: Reza Muhammad , Mirsa Rinaldi , Saputra Eri
Published: April 2024

Penelitian ini bertujuan untuk mengembangkan pariwisata pesisir di Pantai Kuala Raja di Kabupaten Bireuen, Provinsi Aceh. Kawasan pesisir tersebut memiliki potensi wisata yang luas dan keindahan alam yang menarik, namun masih menghadapi berbagai permasalahan yang perlu ditangani. Dalam penelitian ini, fokus utama adalah menganalisis permasalahan seperti degradasi lingkungan dan fasilitas pendukung yang kurang memadai. Pada Pantai Kuala Raja, terdapat degradasi lingkungan yang disebabkan oleh kurangnya pengelolaan sampah yang baik. Sampah seperti plastik dan kulit kelapa sering ditemukan berserakan di bibir pantai. Selain itu, kurangnya fasilitas pendukung juga menjadi masalah, seperti tempat parkir yang tidak tertata dengan baik meskipun memiliki luas pantai yang cukup. Hal ini menyebabkan kendaraan parkir sembarangan dan mengganggu keindahan pantai. Selain itu, pondok-pondok penjual makanan juga terlihat kurang terawat dan kumuh. Hasil dari penelitian ini diharapkan dapat memberikan panduan dan rekomendasi kepada pemerintah daerah dan pemangku kepentingan terkait untuk mengembangkan pariwisata pesisir di Pantai Kuala Raja. Pengembangan pariwisata yang berkelanjutan akan memperhatikan kelestarian lingkungan, meningkatkan fasilitas pendukung, dan menciptakan pengalaman wisata yang menarik bagi pengunjung. Selain itu, diharapkan juga dapat memberikan manfaat ekonomi bagi masyarakat setempat, seperti peningkatan pendapatan, lapangan kerja, dan pemberdayaan ekonomi lokal.
Factors Affecting Activities to Protect the Ideological Foundation of the Communist Party of Vietnam in Current Socio-Economic Development
Authors: Huong Le Thi Thuy , Tan Bui Hoang
Published: April 2024

This paper reports many factors affecting protecting the ideological foundation of the Communist Party of Vietnam and fighting against wrong and hostile views, focusing on an analysis of the ability of the Communist Party of Vietnam to lead the country. Using qualitative research methods of political science such as the historical method, and the logical method. This study aims to analyze the comprehensive construction work of the Communist Party of Vietnam; its policies, facilities, and technical infrastructure; capacity and bravery of the people, officials, and socio-political organizations. The findings of the study indicate that accurately the nature of historical phenomena and events conclude with scientific value. Therefore, this study is examined the factors that influence protecting the ideological foundation Marxist-Leninist of Vietnam within the context of Vietnamese changing and developing.
Effects of Microplastics on Mental Health
Authors: Sönmez Doğancan
Published: April 2024

The impact of microplastics on mental health is an emerging area of research, and the medical literature points to potential neurobehavioral effects. Studies have shown that exposure to microplastics can lead to changes in behavior, neurotoxicity, and cognitive impairments in animal models. Although these findings from animal studies suggest a possible link between microplastic exposure and mental health outcomes, it is important to note that research in this area is still limited and more studies are needed to understand the mechanisms and consequences for human health.
Irritação, críticas e rispidez em interações on-line: um estudo sobre o funcionamento sociointeracional da impolidez em jogos eletrônicos multiplayer
Authors: Santana Gabriel do Nascimento , Barreto Filho Ricardo , Martins Pereira Sônia Virginia
Published: April 2024

Partindo da recorrente crença de que o “discurso agressivo” é parte basilar da interação em jogos eletrônicos on-line, este estudo investigou o funcionamento da interação entre múltiplos jogadores de uma mesma equipe. Buscou-se analisar como, por meio dos mecanismos de (im)polidez, os interactantes elaboram estratégias coletivas. Foi empregada uma metodologia qualitativa-interpretativista, e a escolha do jogo League of Legends se deu pelo fato de ser amplamente reconhecido como o mais representativo no universo dos jogos competitivos. Os resultados indicaram que, ao tensionar funções/papéis em situações conflituosas, os interactantes foram compelidos a elaborar estratégias de manutenção da harmonia na interação.
Atributos morfosedimentarios y concentración de metales pesados en la cuenca del río Aroa, Venezuela
Authors: Vina Orlando José Cabrera , Taborda da Silveira Claudinei
Published: April 2024

La geomorfología estudia la configuración del espacio natural sobre el cual el hombre desarrolla o prevé usar la tierra. El objetivo principal fue determinar la relación entre los atributos morfosedimentarios fluviales con la concentración de metales pesados (MP) presentes en la cuenca del río Aroa, con énfasis en las características granulométricas de los sedimentos de fondo del río. Para ello, fue necesario caracterizar las condiciones geológicas, geomorfológicas y de uso de la tierra de la cuenca del río Aroa que favorecen la presencia de metales pesados (MP) en los sedimentos del fondo. En la mayoría de las áreas muestreadas el uso de la tierra tiene poca relevancia en las concentraciones MP, a excepción del cadmio, vanadio y níquel. Este estudio sirve como herramienta para la exploración minera en medios aluvionales, lo que reduciría significativamente el impacto ambiental.
The prevalence of acute kidney injury in patients with community-acquired pneumonia who required mechanical ventilation
Authors: Almutairi Abdulmajed , Alenezi Farhan , Tamim Hani , Sadat Musharaf , Humaid Felwa Bin , AlMatrood Amal , Syed Yadullah , Arabi Yaseen
Published: April 2024

BACKGROUND:

Community-acquired pneumonia (CAP) is a common reason for intensive care unit (ICU) admission and sepsis. Acute kidney injury (AKI) is a frequent complication of community-acquired pneumonia and is associated with increased short- and long-term morbidity and mortality and healthcare costs.

OBJECTIVE:

Describe the prevalence of AKI in patients with CAP requiring mechanical ventilation and evaluate its association with inhospital mortality.

DESIGN:

Retrospective cohort

SETTING:

Intensive care unit

PATIENTS AND METHODS:

We included patients with CAP on mechanical ventilation. Patients were categorized according to the development of AKI in the first 24 hours of ICU admission using the Kidney Disease Improving Global Outcomes (KDIGO) classification from no AKI, stage 1 AKI, stage 2 AKI, and stage 3 AKI.

MAIN OUTCOME MEASURES:

The primary outcome was hospital mortality. Secondary outcomes were ICU mortality, hospital and ICU length of stay, ventilation duration, tracheostomy, and renal replacement therapy requirement.

RESULTS:

Of 1536 patients included in the study, 829 patients (54%) had no AKI while 707 (46%) developed AKI. In-hospital mortality was 288/829 (34.8%) for patients with no AKI, 43/111 (38.7%) for stage 1 AKI, 86/216 (40%) for stage 2 AKI, and 196/380 (51.7%) for stage 3 AKI (
P
<.0001). Multivariate analysis revealed that stages 1, 2, or 3 AKI compared to no AKI were not independently associated with in-hospital mortality. Older age, vasopressor use; decreased Glasgow coma scale, PaO
2
/Fio
2
ratio and platelet count, increased bilirubin, lactic acid and INR were associated with increased mortality while female sex was associated with reduced mortality.

CONCLUSION:

Among mechanically ventilated patients with CAP, AKI was common and was associated with higher crude mortality. The higher mortality could not be attributed alone to AKI, but rather appeared to be related to multi-organ dysfunction.

LIMITATIONS:

Single-center retrospective study with no data on baseline serum creatinine and the use of estimated baseline creatinine distributions based on the MDRD (Modification of Diet in Renal Disease)equation which may lead to an overestimation of AKI. Second, we did not have data on the microbiology of pneumonia, appropriateness of antibiotic therapy or the administration of other medications that have been demonstrated to be associated with AKI.
Metformin and risk of hematological cancers in patients with diabetes: a systematic review and meta-analysis
Authors: Wang Min , Noghabaei Giti , Raeisi Tahereh , Li Dandan , Alizadeh Hamzeh , Alizadeh Mohammad
Published: April 2024

The effect of metformin use in patients with diabetes against the hematological cancers (HCs) has been contradictory. This meta-analysis, carried out on studies published in databases, aimed to investigate the association of metformin use and the odds of HCs. We systematically searched Scopus and PubMed databases to include related studies considering the relation of metformin use and the risk of HCs as outcome. Eleven studies, comprising a total of 2 318 217 participants, were included. The analysis revealed that metformin use in patients with diabetes was significantly associated with a decreased risk of HCs (OR=0.88; 95%CI: 0.79–0.98), with significant heterogeneity. In the subgroup analysis, this association was found to be significant only for multiple myeloma (OR=0.67; 95% CI: 0.55–0.81). A significant evidence for heterogeneity and publication bias was detected. Metformin use in patients with diabetes may be linked to the reduced risk of HCs.

FUNDING:

No external funding.
PENGARUH PENDEKATAN MATEMATIKA REALISTIK TERHADAP HASIL BELAJAR SISWA SMP PADA POKOK BAHASAN LINGKARAN
Authors: Qadry Ikhbariaty Kautsar , Alfiah Asti Nur
Published: April 2024

Penelitian ini merupakan penelitian kuantitatif yang bertujuan untuk mengetahui pengaruh pendekatan matematika realistik terhadap hasil belajar matematika siswa kelas VIII SMP Negeri 2 Batang. Sampel penelitian ini adalah 28 orang yang dipilih menggunakan Teknik simple random sampling. pengumpulan data yang dilakukan adalah tes hasil belajar siswa (pretest-posttest) untuk mengukur hasil setelah mengikuti proses pembelajaran, lembar aktivitas siswa untuk mengamati aktivitas siswa selama proses pembelajaran berlangsung, Angket Respons siswa untuk mengetahui respons siswa terhadap proses pembelajaran. lembar observasi keterlaksanaan untuk mengetahui keterlaksanaan pengelolahan pembelajaran di kelas. Data yang diperoleh selanjutnya dianalisis dengan statistik deskriptif dan inferensial. Hasil penelitian menunjukkan bahwa penerapan pendekatan matematika realistik berpengaruh terhadap hasil belajar matematika siswa kelas VIII SMP Negeri 2 Batang dengan uraian sebagai berikut. Rata-rata hasil belajar matematika siswa pada pretest adalah 26,46; sedangkan pada posttest adalah 82,32. selain itu, peningkatan hasil belajar matematika siswa berada pada kategori tinggi. Hal ini ditunjukkan oleh hasil perhitungan rata-rata gain ternormalisasi siswa sebesar 0,76. Juga aktivitas siswa selama proses pembelajaran dengan pembelajaran ini berada pada kategori sangat baik dengan rata-rata siswa aktif sebanyak 87,14%. Sementara itu, sebanyak 86% siswa merespons positif penerapan pembelajaran ini. Terakhir, keterlaksanaan pembelajaran ini termasuk ke dalam kategori sangat baik dengan rata-rata sebesar 95%. Disimpulkan bahwa penerapan pendekatan matematika realistik (PMR) berpengaruh terhadap hasil belajar matematika siswa pada kelas VIII.1 SMP Negeri 2 Batang, dilihat dari hasil belajar matematika siswa, aktivitas siswa, respons siswa, dan keterlaksanaan pembelajaran.
HUBUNGAN ANTARA INTENSITAS PENGGUNAAN MEDIA SOSIAL DENGAN BODY DISSATISFACTION PADA MAHASISWA DI DAERAH ISTIMEWA YOGYAKARTA
Authors: Sudiasi Bai , Ariyanto Mustaqim Setyo
Published: April 2024

Penelitian ini bertujuan untuk menguji dan menjelaskan hubungan antara intensitas penggunaan media sosial dengan body distatisfaction. Responden dalam penelitian ini sebanyak 110 mahasiswa mencakup perempuan dan laki-laki di Daerah Istimewa Yogyakarta. Pengambilan sampel dilakukan dengan teknik Insidental Sampling dan Snowball Sampling. Instrumen yang digunakan adalah skala multiple body-self related quessionare appearance scales (MBSRQ-AS) dan skala intensitas penggunaan media sosial. Teknik analisi data yang digunakan adalah ini korelasi pearson product moment. Hasil analisis data diperoleh nilai r = 0,423 dengan p = 0,001 (p< 0,01) menunjukan terdapat hubungan yang signifikan antara intensitas penggunaan media sosial dengan body dissatisfaction. Berdasarkan hasil penelitian dan pembahasan, dapat dilihat bahwa terdapat hubungan yang signifikan antara intensitas penggunaan media sosial dengan body dissatisfaction pada mahasiswa di Daerah Istimewa Yogyakarta. Oleh karena itu, penggunaan media sosial yang tidak produktif sebaiknya dihindari untuk menghindari terjadinya body statisfaction dan meningkatkan produktifitas mahasiswa sebagai agen perubahan masa depan.
HUBUNGAN ANTARA TEKANAN AKADEMIK DENGAN KECEMASAN MASA DEPAN PADA MAHASISWA
Authors: Hazlinda Mutia , Salim Agus
Published: April 2024

Penelitian ini dilakukan dengan tujuan mengetahui hubungan antara tekanan akademik dengan kecemasan masa depan pada mahasiswa. Penelitian ini memiliki total 100 responden, yang terdiri dari mahasiswa laki-laki dan perempuan berusia antara 18 dan 25 tahun. Penelitian ini menggunakan pendekatan stratified random sampling untuk pengambilan sampel. Instrumen yang digunakan terdiri dari skala kecemasan masa depan dan skala skala tekanan akademik. Teknik analisis data yang digunakan adalah koefisien korelasi Sperman rank rho. Hasil yang diperoleh dari analisis data menghasilkan koefisien korelasi sebesar r = 0,731, dengan nilai p-value 0,000 (p < 0,005), yang menunjukkan hubungan yang sangat signifikan antara tekanan akademik dengan kecemasan masa depan pada mahasiswa. Hasil yang diperoleh menunjukkan adanya hubungan yang kuat antara tekanan akademik dan kecemasan masa depan di kalangan mahasiswa di Daerah Istimewa Yogyakarta, dengan demikian, semakin tinggi tekanan akademik maka semakin tinggi pula kecemasan masa depan pada mahasiswa.
Analisis Peningkatan Minat Belajar Siswa Melalui Penerapan Model Game-Based Learning
Authors: Fatimah Oryza Lisativani , Abdul Halim Fathani  , Awae Waekhodiyoh
Published: April 2024

Penelitian ini dilatarbelakangi oleh rendahnya minat siswa Kelas X di sekolah Ekkapapapassanawich, Krabi, Thailand untuk belajar matematika materi aljabar, karena proses belajar yang terlalu kaku dan monoton. Hal ini terjadi, karena sekolah dan guru belum menciptakan sistem belajar yang bervariasi bagi siswa. Maka dari itu, penelitian ini bertujuan menganalisis peningkatan minat belajar pada matematika materi aljabar dalam penggunaan model Game-Based Learning (GBL). Penelitian ini menggunakan metode campuran (Mixed Methods) dengan desain pre-eksperimental, jenis penelitian quasi experiment dengan one group pre-test dan post-test. Populasi penelitian ini adalah semua siswa kelas X di sekolah Eakkapapsasanawich, Krabi, Thailand tahun Pelajaran 2023/2024. Teknik penentuan sampel dilakukan dengan menggunakan teknik random sampling. Sampel dalam penelitian ini terdiri dari 2 kelas yaitu kelas XA dan XB, masing-masing ada 34 siswa, maka jumlah subjek penelitian tersebut ada 68 siswa. Penelitian inj menggunakan uji Wilcoxon Signed Rank Test dengan bantuan aplikasi SPSS 26.0 for Windows. Sedangkan data kualitatif diperoleh dari observasi dan wawancara dengan perwakilan siswa dan guru yang dianalisis menggunakan analisis naratif. Penelitian ini dilakukan dengan melakukan pre-test berupa angket mengenai minat belajar matematika aljabar siswa sebelum menggunakan Model Game-Based Learning (GBL). Selanjutnya, dilakukan post-test berupa angket mengenai minat siswa dalam belajar matematika materi aljabar dengan menggunakan Metode Game-Based Learning (GBL). Hasil uji hipotesis yang dihasilkan menunjukkan tingkat signifikansi sebesar 0,000 yang atinya Ha diterima dan H0 ditolak. Selain itu, data hasil wawancara menunjukkan bahwa preferensi dan minat siswa terhadap materi aljabar dengan Model Game-Based Learning (GBL) semakin meningkat.
Strategi Visioner Kepala Sekolah Dalam Meningkatkan Mutu Pendidik Di SMK
Authors: Khotimah Dian Khusnul , Tyas Zuhriana Widya Rahayu Ning , Hikmawati Hanifah
Published: April 2024

Penelitian ini bertujuan untuk mengeksplorasi upaya kepala sekolah dalam membangun mutu pendidik di SMK PGRI 1 Ngawi. Metode penelitian yang digunakan dalam penelitian ini adalah metode kualitatif. Penelitian kualitatif digunakan untuk mendapatkan pemahaman mendalam tentang bagaimana kepala sekolah membangun mutu pendidik di SMK PGRI 1 Ngawi melalui penerapan strategi visioner. Teknik pengumpulan data yang digunakan meliputi wawancara, observasi, dokumentasi, dan rekaman. Analisis data dilakukan secara deskriptif untuk menggambarkan dan menjelaskan temuan dari penelitian ini. Melalui penerapan kedisiplinan, ketuntasan, dan keterpantauan, kepala sekolah berperan penting dalam meningkatkan mutu pendidik yang berkontribusi pada keberhasilan pendidikan dan pembelajaran. Strategi visioner digunakan untuk menciptakan mutu pendidikan yang jelas dan strategis untuk masa depan, serta melibatkan seluruh elemen yang ada dalam mensukseskan visi peningkatan mutu pendidik. Hasil penelitian ini memberikan gambaran tentang peran penting kepala sekolah dalam membangun mutu pendidik di SMK PGRI 1 Ngawi. Kontribusi: Temuan penelitian ini dapat menjadi acuan bagi pengembangan kebijakan dan praktik pendidikan yang lebih efektif, serta memberikan wawasan baru dalam bidang kepemimpinan pendidikan.
Model PIMCA Dalam Pembelajaran Statistika: Implementasi Dan Dampaknya Terhadap Hasil Belajar Siswa
Authors: Pusut Talita , Regar Vivian E. , Sulistyaningsih Murni
Published: April 2024

Keterampilan pemecahan masalah merupakan ketrampilan yang penting dimiliki siswa saat ini. Akan tetapi masih banyak peserta didik yang memiliki keterampilan pemecahan masalah yang rendah. Hal ini tentunya mempengaruhi hasil belajar mereka. Terutama pada pembelajaran statistika. Penelitian ini bertujuan untuk mengetahui pengaruh Implementasi Model PIMCA Pada Pembelajaran Matematika Materi Statistika terhadap hasil belajar siswa di SMP Negeri 3 Gemeh di Bannada. Metode penelitian ini menggunakan Quasi Eksperimen yaitu metode penelitian yang mempunyai kelompok Eksperimen dan Kontrol, dengan menggunakan sampel 40 orang siswa. Hasil Penelitian menunjukkan metode Pembelajaran PIMCA dapat mempengaruhi hasil belajar siswa mata pelajaran Matematika materi statistika pada Kelas VIII SMPN 3 Gemeh Bennada. Hal ini dapat ini dapat dilihat dari hasil uji hipotesis ditemukan nilai thitung > ttabel (3.529 > 1.686) dengan nilai sig (2 tailed) 0.001 < 0.05 dimana dapat simpulkan bahwa terdapat perbedaan rata-rata hasil belajar siswa yang menggunakan model pembelajaran PIMCA dengan siswa menggunakan model pembelajaran konvensional.
Pengembangan Buku Ajar Statistika Pendidikan Berbasis Kontruktivisme Dengan Model ADDIE
Authors: Yusuf Munir , Lestari Alia , Musa Lisa Aditya Dwiwansyah
Published: April 2024

Penelitian ini bertujuan untuk menghasilkan buku ajar mata kuliah Statistika Pendidikan Berbasis Konstruktivisme yang akan digunakan sebagai salah satu pedoman mengajar dosen dan sumber belajar bagi mahasiswa. Pengembangan buku ajar ini menggunakan model pengembangan ADDIE. Instrumen yang digunakan untuk mengumpulkan data adalah angket dan pedoman wawancara. Data dianalisis dengan menggunakan rumus dan pengkategorian. Hasil yang diperoleh yaitu buku ajar yang disusun telah memenuhi syarat kelayakan. Dengan Tingkat kelayakan isi buku sebesar 90,00% dengan kategori sangat baik, kelayakan desain buku sebesar 80,00% dengan kategori baik. Sedangkan Tingkat kelayakan media sebesar 82,86% dengan kategori baik. Tingkat kelayakan uji terbatas perorangan dosen pengampuh mata kuliah sebesar 93,33% berada pada kategori sangat baik dan mahasiswa sebesar 91,88% yang berada pada kategori sangat baik, serta uji kelompok kecil diperoleh sebesar 91,38% dengan kategori sangat baik. Setelah melalui proses revisi draf buku ajar, diperoleh buku ajar yang layak untuk digunakan pada mata kuliah statistika pendidikan.
Towards the Development of a Career Path Recommender System for Senior High School in Selected Public Schools using Multi-Label Classification
Authors: Bucad Abelardo T.
Published: April 2024

The Philippines challenged accepting reforms that shifted 10-year to the k-12 basic education program, adding two years to the students’ basic education. Each graduate student from the grade 10 level must choose a career path that will give them the skills they need to be future-ready. Given the long-term effects on a student’s career, selecting the SHS track or strand is one of the most important life decisions they will ever make. In this paper, a career path recommender system will introduce to avoid a mismatch of strands/tracks and help the students choose the possible career path in Senior High School (SHS) that fits their taste and capability. The researcher will collect related data from six (6) selected public schools offering grade 10 in Valenzuela City. And will explore different student data such as family background, big five personalities, grades, IQ test, and some tools in the Multiple Development Toolkit from Department of Education (Self-assessment and career interest cluster, Personal career exploration). The study will use content-based filtering and classification algorithm in machine learning like Decision trees (DT), K-Nearest Neighbor (KNN), Naïve Bayes (NB), and Support Vector Machine (SVM) that will serve as base-classifier in the multi-label classification.
TRANSFORMING FINANCIAL PLANNING WITH AI-DRIVEN ANALYSIS: A REVIEW AND APPLICATION INSIGHTS
Authors: Lawrence Damilare Oyeniyi  , Chinonye Esther Ugochukwu  , Noluthando Zamanjomane Mhlongo
Published: April 2024

In the ever-evolving tapestry of financial planning, the integration of Artificial Intelligence (AI) emerges as a pivotal force, redefining the contours of strategic decision-making and operational efficiency. This paper delves into the historical progression, current implementations, and the multifaceted impact of AI within the financial planning sphere, aiming to unravel the complexities and transformative potential of AI technologies. Through a rigorous examination of peer-reviewed literature and empirical studies, the research meticulously maps the trajectory of AI's integration in finance, from its nascent stages to its current stature as a cornerstone of financial innovation. The study's methodology, rooted in qualitative analysis, systematically explores the enhancements AI brings to financial decision-making, the challenges it poses, including ethical considerations and regulatory compliance, and the qualitative shifts in financial strategies engendered by AI adoption. The findings illuminate AI's dual role as both a catalyst for unprecedented efficiency and a harbinger of new challenges, underscoring the need for a balanced approach to its integration. Conclusively, the paper advocates for a harmonious blend of innovation and ethical stewardship, recommending that financial institutions embrace AI's potential while rigorously addressing its challenges through continuous learning, adaptability, and ethical vigilance. The recommendations aim to guide stakeholders through the labyrinth of AI integration, ensuring that financial planning becomes more efficient and strategic and remains equitable and transparent. This study serves as a beacon for future exploration, offering insights into navigating the complexities of AI-driven financial planning.

Keywords:  Artificial Intelligence, Financial Planning, Strategic Decision-Making, Ethical Considerations, Regulatory Compliance, Technological Innovation.
BLOCKCHAIN'S IMPACT ON FINANCIAL SECURITY AND EFFICIENCY BEYOND CRYPTOCURRENCY USES
Authors: Philip Olaseni Shoetan  , Babajide Tolulope Familoni
Published: April 2024

Blockchain technology, originally developed for digital currencies, has evolved to offer transformative prospects for enhancing financial security and efficiency beyond its initial application. This review paper explores the expansive utility of blockchain technology across various domains, with a special focus on its implications for green logistics innovations within the oil industry, drawing a comparative analysis between Nigeria and the USA. Through a comprehensive review of existing literature, this study aims to uncover the multifaceted impact of blockchain on streamlining operations, ensuring transparency, and fostering sustainability in the oil sector's supply chain management.

The methodology hinges on synthesizing findings from peer-reviewed articles, industry reports, and case studies to construct a holistic view of blockchain's role in mitigating traditional challenges faced by the oil industry, such as fraud, inefficiencies, and environmental concerns. By comparing the progress and setbacks in Nigeria and the USA, the paper delineates the influence of regulatory frameworks, technological infrastructure, and stakeholder engagement on the adoption and effectiveness of blockchain solutions.

Key findings reveal that blockchain technology can significantly elevate financial security and operational efficiency, offering a robust framework for transparent, immutable transactions and supply chain oversight. However, the comparative analysis highlights a notable divergence in adoption levels and outcomes, attributed to varying degrees of technological readiness, regulatory environments, and commitment to sustainability goals between the two countries.

Conclusively, the paper emphasizes that the broader application of blockchain in enhancing green logistics and sustainability within the oil industry requires a concerted effort among policymakers, industry leaders, and technology providers. It advocates for targeted investments in technology infrastructure, clearer regulatory guidelines, and stronger collaborations to harness blockchain's full potential, suggesting a pathway towards more secure, efficient, and sustainable industry practices.

Keywords:  Blockchain Technology, Financial Services, Smart Contracts, Decentralized Finance (Defi), Regulatory Landscape, Ethical Considerations, Privacy Concerns, Data Protection, User Anonymity, Operational Efficiency, Financial Security, Scalability Issues, Energy Consumption, Consensus Mechanisms, International Regulations, Jurisdiction-Specific Challenges, Technology Adoption, Integration Strategies, Innovation, Collaboration, Financial Ecosystem.