bluuebunny/crossref_metadata_2025 huggingface dataset:
Pathological spectrum of lung lesions diagnosed by sputum cytology: A three years retrospective study in a tertiary health care centre of North India
Authors: Gangopadhyay Gourik , Siddiqui Bushra
Published: July 2023

Sputum Cytology is a cheap and noninvasive investigation contributing significantly to the workload of Cytopathology Laboratories. However, over the years, the use of Sputum Cytology has depreciated. It has been taken over by more advanced procedures like Broncho Alveolar Lavage and Trans Bronchial Needle Aspiration, which are comparatively invasive and expensive requiring a much higher learning curve. Hence, the usefulness of noninvasive samples like Sputum needs to be explored in resource limited settings.

To study the spectrum of Lung lesions diagnosed using Sputum Cytology with Histopathological correlation wherever possible.

: This was a three years retrospective study. Data of patients who had come with sputum sample was retrieved from the archives of the cytopathology lab between July 2019 and June 2022. Cytology findings were correlated with histopathological diagnosis, wherever possible.

Out of the total sample size of 143, 67 showed inflammatory infiltrate, 1 out of which was confirmed to be malignant on biopsy. 17 cases were suspected to be malignant, out of which 15 were confirmed on biopsy. Other samples revealed the presence of fungal infection, dysplasia with no frank malignancy and reactive changes.

Our study shows that sputum testing can be quite an accurate method in the early diagnosis of many lung lesions including malignancies. The Sensitivity and Specificity for malignancy was 83.33% and 95% respectively. Therefore, it can be applied as a cheaper, noninvasive ideal screening test for the early detection of lung pathologies especially in resource poor settings.
Histopathological spectrum of cardiovascular findings in forensic autopsies in Hadoti region: A prospective study of one year
Authors: Chaudhary Anamika , Rai Naresh N.
Published: July 2023

Heart diseases are now the biggest killer in the world. Many cardiovascular pathologies are concealed and found incidentally on post mortem examination.

To analyse spectrum of histopathological lesions (related or unrelated to cause of death) in heart autopsies in Hadoti region of Rajasthan.

This was a one year prospective hospital-based study. A total of 133 whole heart specimen underwent detailed gross and microscopic examination.

Most common histopathological finding was atherosclerosis, seen in 63 cases out of 133 autopsied hearts (47.3%), followed by myocardial hypertrophy in 31 cases and myocardial infarction in 20 cases. Age related changes were seen in 10 cases, severe congestion in 10 cases, myocardial fibrosis in 7 cases. 1 case each of infective endocarditis, myocardial calcification, ventricular rupture, myocarditis, LAD stent, fat embolism was noted. 51 hearts did not reveal any sort of pathology. Correlation of age with atherosclerosis showed a significant p value (0.0009). Males showed a slightly higher prevalence of atherosclerosis but it was not statistically significant. We had 39 (29.3%) cases of sudden cardiac deaths (SCD). SCD cases showed similar histopathological spectrum as all other causes of deaths, but percentage of each heart pathology was much higher in SCD. Most common finding among SCD cases was coronary artery disease (23 cases), followed by myocardial hypertrophy (22 cases) and myocardial infarction (13 cases). Myocardial Fibrosis was seen in 3 cases, age related changes in 2 cases, ventricular rupture in 1 case and severe congestion in 1 case. 61.5% SCD cases showed combination of two or more pathologies. Five SCD cases did not reveal any pathology.

In our study heart pathologies make a major contribution towards ill health and death in our society, atherosclerosis being the most common finding.
Canalicular adenoma of parotid gland: A case report and review of literature
Authors: Thangaraja Anusha , Ramaswamy Veena , B N Tejaswini , Uthaiah Sowmya B
Published: July 2023

Canalicular adenoma is a rare benign salivary gland neoplasm affecting predominantly the minor salivary gland. We present a case of a 55 year female who presented with a mucosal nodule in the left cheek and was diagnosed as Canalicular adenoma based on the morphology and immunohistochemistry findings. Our case is rare in that, it is a case of Canalicular adenoma affecting the major salivary gland – Parotid gland, and is the 7 case reported in literature to the best of our knowledge.
An interesting case of papillary thyroid carcinoma with heterotrophic ossification
Authors: Bharathi U , Porko Sivaganesh , Priyadharisini J
Published: July 2023

Calcification in thyroid gland is associated with both benign and malignant lesion. However calcification is most frequently seen in malignant lesions. Calcification can give rise to metaplasia and bone containing marrow tissue. Papillary carcinoma with heterotrophic ossification has been associated with high incidence extrathyroidal invasion, multifocality, lymphnode metastsasis and older age group than in those without heterotrophic ossification. It has not been described as a specific entity in WHO classification because of its rarity. Expression of both basic fibroblast growth factor and bone morphogenetic protein was highest in papillary carcinoma with intratumoral heterotrophic ossification. In this case report we described a 71-year-old female patient who sought medical care for swelling in the neck for the past 4 years. The cervical ultrasound showed a 2 well defined nodules measuring 2x2 cms and 4mm in the right lobe with larger lesion showing peripheral rim of calcification and left lobe and isthumus shows well defined lesions measuring 5mm and 4 mm each. The clinical diagnosis was multinodular goitre. Patient subsequently underwent thyroidectomy. On histopathological investigation right lobe showed follicular adenoma and papillary carcinoma thyroid with extensive heterotrophic ossification and calcification within the tumor. The margins were free of neoplasia and there was no extrathyroidal extension. No preineural/ vascular invasion noted. One lymphnode was identified which was free of tumor. pTNM staging was pT1bNxMx.
Mysterious death of student in hostel: A case report and its medico -legal aspect
Authors: Md. Irfan Ali  , Shandil Anil , Abhay Abhinav , Ranjan Ashish , Kumar Suresh , Verma Dilesh Kumar , Kumar Ravi
Published: July 2023

Smothering is a form of asphyxia, caused by either closing or blocking the external respiratory orifices i.e. mouth and nose. Deaths from smothering may or may not be accompanied by physical signs of evidence during autopsy depending upon the manner or circumstances making the autopsy surgeon’s task a daunting challenge. A strangulation is a form of violent asphyxia death caused by constriction of air passage at the neck by means of ligature or by any means other than suspension of the body. Suicide by strangulation is rare. In the absence of signs of violence and marks of a struggle, the task becomes more difficult. Here we report one such case of a student staying in a hostel who died in a mysterious circumstance, whose dead body was found lying in a car outside the hostel premises and the manner concluded after studying the injuries tediously in summation with the detailed history of the case and FSL report of visceral chemical analysis, ligature material report and report of the scene of incidence.
A case of glyphosate poisoning
Authors: Choudhary Samyogita , Chakraborty Sayan , Goswami Laxmi , Sen Dhiman
Published: July 2023

Glyphosate is a commercially available herbicide which also acts as a human toxin. It produces a wide range of clinical manifestations ranging from throat irritation, GI tract erosion and bleeding, surfactant elated liver and kidney injury, metabolic acidosis and even death. We are reporting a case of a 36 year old female who consumed around 400ml of the pesticide and presented to our tertiary care hospitals after 12 hours of ingestion, in a state of renal shutdown, Severe acidosis and hyperkalemia and shock. We started on hemoperfusion and CRRT apart from the initial resuscitation. She was successfully treated and discharged home. This case report emphasise on the use of hemoperfusion toxin removing cartridge for sever glyphosate poisoning as there is no known antidote of this toxin and also the mechanism of toxicity is still not well-established?
Влияние цифровизации на систему управления рисками организации
Authors: Пархоменко И.А.
Published: July 2023

В статье представлена концепция влияния цифровизации современной экономики на экономические процессы. Отмечено, что цифровизация экономики не устраняет из экономической деятельности предприятия состояния рыночной неопределенности и возможных рисков. Подтверждено, что наряду с традиционными видами рисков экономической деятельности (например, политическими, рисками, связанными с ликвидностью, появлением новых конкурентов, продуктов) возникают новые более значимые
Государственный и муниципальный заказ: сущность в системе государственного регулирования экономики
Authors: Эльбиева Л.Р
Published: July 2023

В статье рассматривается социально-экономические и правовые аспекты системы государственного и муниципального заказа как инструмента развития экономики территории. Определена роль органов власти в регулировании системы государственного и муниципального заказа, изучена сущность, цели и функции государственного и муниципального заказа в системе государственного регулирования экономики
Понятие системы социальной защиты населения и история ее становления
Authors: Эльбиева Л.Р
Published: July 2023

Под социальной поддержкой и защитой населения понимаются меры, осуществляемые государством и общественными организациями, которые обеспечивают гарантированные минимальные условия жизнедеятельности человека, и положительно влияют на интеграцию человека в систему социальных отношений. В статье рассматривается система социальной защиты, куда входят комплекс законодательных актов, мероприятий, организаций, которые обеспечивают осуществление социальной защиты населения
Формирование цен на товары и услуги
Authors: Эскерханова Л.Т
Published: July 2023

В данной статье рассматривается тема формирования цен на товары и услуги. Были описаны основные методы определения цен, такие как метод стоимости, метод конкурентной цены, метод спроса и метод маркетингового ценообразования. В частности, была подробно рассмотрена стратегия динамических цен, которая позволяет компаниям адаптироваться к изменениям на рынке и удовлетворять потребности потребителей.
Особенности перевода кинофильмов с корейского на русский язык
Authors: Асылбек М
Published: July 2023

В связи с ростом популярности корейской индустрии и большим спросом на кинопродукцию, аудиовизуальный перевод начинает набирать обороты. Данная тема является актуальной в наше время, так как тенденция работы с аудиовизуальным форматом корейских кинофильмов и киносериалов пришла не так давно. Данная статья направлена на выявление и анализ работы переводчиков, которые работают с материалом на корейском языке и занимаются адаптацией на русский язык
Роль английского языка в развитии бизнеса
Authors: Терѐхин Т.Э., , Нижельская Ю.А , Нижельская Д.А
Published: July 2023

На сегодняшний день английский язык является международным языком, которым пользуется большинство стран мира в процессе развития разных отраслей собственного хозяйства. В большей степени данным языком владеют представители бизнеса, общаясь с партнѐрами. Деловой английский становится жизненно важным инструментом для построения отношений между предпринимателями, профессионалами и сотрудниками международных компаний. Именно умение вести переписку и правильно общаться определяет имидж и профессиональный уровень деловых партнеров и совместного сотрудничества
English as a universal tool for international professional communication
Authors: Teryokhin T.E , Nizhelskaya J.A , Nizhelskaya Yu.A , Nizhelskaya J.A
Published: July 2023

The article examines the importance of the English language as a universal tool for international professional communication. In today's world, where international relations are becoming denser and intense, the ability to speak and understand English is becoming a necessary skill for professionals in many industries. The article describes the benefits of using English in professional communication, and also offers recommendations for learning it. The author emphasizes that the need for the ability to communicate in English is increasing every year, and that the effective use of this language not only facilitates international communication, but can also increase the chances of success in a career
THE ART OF BEING THE HUMAN OF PRINCIPLE: REMEMBRANCE OF OLGA VAVILOVA
Authors: Saienko Valentyna
Published: July 2023

The memorial article is in honor to the personality of Olga Ivanivna Vavilova, who was born and grew as a specialist of the highest qualification, the candidate of pedagogical sciences, docent of Pedagogics department, being constantly more than 40 years under the sign of Odesa I .I. Mechnikov National University. And by her devoted working she succeeded and gained authority both in teaching and assisting position and later as the Head of trade union committee of the alma-mater, actively caring of a high ratio of the only one classical university of the South of Ukraine with a 160 years history among countries and foreign higher educational institutions with the administration and rectorate. Being initiative and active person, Olga Vavilova together with the editorial board (M. Podrezova, M. Sherban, N. Jurgelaytys) founded “They are Originally from the University” with the purpose to promote the achievements of Odesa I. I. Mechnikov National University via popularization a wide range of creative interests of its fully talented employees. In an accompanied foreword for the collection (2012–2019) under the title “Ne Hlibom Yedynym...” Olga Vavilova presented the main motto of the edition “There are a lot of employees in the university, whose talent and creative interest is broader than just occupation. Honest word, that gives optimism and spiritual power, will find a grateful feedback in the hearts of all enthusiasts of beauty in our opinion. So that’s this collection have all the chances to become an original, even now modest, contribution to the common heritage of spiritual existence of Ukrainian culture”. And it became true. Unfortunately, the collection withdrew in 2020. Still, the impact of Olga Vavilova in the life of Odesa I. I. Mechnikov National University is modest but remarkable and important.
INTEGRATING LITERACY STRATEGY IN UPLIFTING COMPETENCY OF STUDENTS: A GUIDE FOR COMPREHENSIVE LEARNING
Authors: D. Mallillin Leovigildo Lito
Published: July 2023

The paper investigates the practice of integration literacy strategies in uplifting competency of students as a guide for comprehensive learning set-up based on the different domains of learning in the area of cognitive learning, affective learning, and psychomotor learning. It also analyzes the extent of the integration of literacy strategies in uplifting competency of students as a guide for comprehensive learning in terms of comprehension level, attitude towards learning, and academic performance.

Quantitative Research Design is employed in the study because it aims at discovering how many people think, act, or feel in a specific way. Likewise, purposive sampling is utilized in the study. The study comprised Eighty (80) respondents only.

Results show that there is an ability to construct meaning from the lesson as to function and activities provided by the lecturer, show that students have the active attention and proper motivation to learn, willing to respond, and feeling of satisfaction, show that students can relate to endurance, flexibility, agility, strength, reaction-response time, show that skills and needs is based on the level of knowledge of students to inspire, motivate and empower to learn and expand critical thinking, show that students express freely their opinion based on the lessons and activities, and show that students pay close attention to the directions and instructions in the lesson setup inside the classroom.

Findings show that there is no significant correlation between the practice of the integration literacy strategies in uplifting competency of students as a guide for comprehensive learning set-up based on the different domains of learning and the extent integration of literacy strategies in uplifting competency of students as a guide for comprehensive learning as observed among the respondents.
Resenha: Educação Bilíngue no Brasil: reflexões a partir da práxis
Authors: Miranda Patricia Ferreira , Zibetti Marli Lúcia Tonatto , Feitosa Débora Ferreira da Silva
Published: July 2023

Publicada em 2021, a obra organizada por Antonieta Megale tem seu fio condutor guiado pelo senso questionador de como se fazer uma Educação Bilíngue no Brasil, considerando as dimensões da realidade escolar, sobretudo, a partir do contexto de pandemia do Covid-19. Partindo de reflexões e experiências de docentes e pesquisadores do bilinguismo, além de prefácio e introdução, o livro conta com oito capítulos que abordam questões como a multiculturalidade, o ensino, a aprendizagem, a avaliação, a consciência fonológica dentre outros aspectos que perpassam a práxis bilingue na escola. Com farta problematização sobre o tema, mas, em igual medida, em proposições didáticas, Educação Bilíngue: como fazer? constitui-se como leitura imprescindível dentro de sua área, ao propor um debate localizado sob a conjuntura e especificidades latino-americana e brasileira, e guiado por um olhar crítico da Linguística Aplicada e da Educação sobre a aprendizagem de línguas estrangeiras na perspectiva do direito linguístico.
Implementation of Maqāṣid Sharī’ah in Reform of Case Management of Violence against Women and Children
Authors: Aibak Kutbuddin
Published: July 2023

This study aims to reflect on the values of maqāṣid sharī’ah in management patterns of violence cases against women and children. This is based on arguments about case management which until now has not been able to completely resolve violence against women and children in Indonesia. The presence of maqāṣid sharī’ah in the management pattern of violence against women and children is expected to hold strong legitimacy to formulate a management pattern that is integrated with the basis and values of Islamic law goals. This step is a form of embodiment to resolve violence cases against women and children through maqāṣid sharī’ah-based case management to reflect the resolution of violence cases through integrated steps to realize solutive fiqh for the matter. In an academic purview, this study uses a literature review involving primary and secondary data observed with in-depth analysis. The findings in this study indicate that maqāṣid sharī’ah has implications for the realization of protection for women and children through case management reforms.
The matK Mini-barcode as a Potential Molecular Identification Tool for Medicinal Orchids
Authors: Suudi Muhammad
Published: July 2023

matK is one of the universal loci which is commonly used as a barcode in the molecular identification of plants. Up to now, the problem of matK as a single locus is the use of the entire gene region as barcodes. The long amplicon size of matK raises several problems in DNA barcoding. The aim of this study is to uncover a small region of the matK gene as a potential mini-barcode region for alternative sites to get more efficient and effective results. In silico studies performed include the collection of matK sequence of medicinal orchid from GenBank, the amplicon size from matK primer sets that are commonly used in the Orchidaceae family, and PCR analysis. Data analysis was done by comparing the results of PCR amplification from several primer sets:  matK 390F-1326R, 743F-R2, 712F-1154R and 712F-1216R. The results show that all primer pairs are able to amplify the DNA template isolated from Dendrobium purpureum. However, the shorter DNA band obtained from matK 743F-R2, 712F-1154R and 712F-1216R primers sets were visualized more thick than the longer amplicon band produced from matK primer 390F-1326R. This indicates that short matK sequence for DNA barcoding (mini-barcode) is more efficient in amplifying DNA templates compared to generally applied barcoding using full length sequences.
Ensino remoto emergencial e a antropologia filosófica na enfermagem
Authors: Silva Rodrigo Rodrigues , Malaquias Bruna Stephanie Sousa , Elias Henrique Ciabotti , Santos Álvaro da Silva
Published: July 2023

Objetivo: relatar a experiência de ações inovadoras para o ensino de Antropologia Filosófica. Método: foi ministrada a disciplina de Antropologia Filosófica na graduação em enfermagem, em 10 encontros virtuais, por meio do Ensino Remoto Emergencial (ERE), com a aplicação de diversas metodologias ativas de ensino-aprendizagem (MAES). Resultados: a disciplina aplicou oito tipos de MAES e atividades lúdicas, além da produção de conteúdos específicos. A motivação para adesão e não abandono do ERE pelos alunos, a interatividade e a ressignificação de saúde sob o ponto de vista antropológico e filosófico foram desfechos importantes dessa intervenção educativa. Conclusão: a definição e aplicação criativa de MAES podem favorecer o ensino de Antropologia Filosófica e à ressignificação do ERE.
A escuta de crianças assentadas sobre educação infantil em teses e dissertações
Authors: Santana Eliane Ceri Assis , Rodrigues Silvia Adriana
Published: July 2023

Este artigo, recorte de pesquisa em andamento junto ao Programa de Pós-graduação em Educação da Universidade Federal de Mato Grosso do Sul - Campus Pantanal, discute dados levantados na Biblioteca Digital de Teses e Dissertações e no site do referido programa. Da busca, que utilizou 26 descritores - isolados e cruzados -, resultou a seleção de 26 trabalhos, cuja organização e análise para escrita do artigo foram feitas com abordagem de um estudo do tipo estado do conhecimento. Os resultados indicam que, embora haja aumento no número de investigações que busca ouvir crianças, ainda são poucos os estudos com criança em idade pré-escolar. Ressaltamos que não foram encontrados trabalhos realizados considerando crianças como colaboradoras na elaboração da pesquisa, nem com objetivo de ouvir crianças assentadas. Merece menção o fato de que, embora os trabalhos selecionados afirmem a necessidade de escuta da criança, a maioria busca outras fontes de informação complementar (oriundas dos adultos) para composição dos dados.
Por uma docência crítica, dialógica e solidária na educação física escolar
Authors: Spolaor Gabriel da Costa , Bonfietti Priscila Errerias , Cibim Julia Pichi , Prodócimo Elaine
Published: July 2023

A pandemia do Covid-19 explicitou inúmeras questões sobre a atuação docente na Educação Física em tempos de distanciamento e ensino remoto. Um grupo de professores/as-pesquisadores/as interessados/as em oportunizar aulas dialógicas e reflexivas decidiu se unir para discutir coletivamente sobre suas práticas. Com base nas ideias do pensamento de Paulo Freire, esta narrativa se configura como um ensaio-reflexivo que levanta as situações-limites enfrentadas pelos/as professores/as, assim como, seu esforço conjunto e solidário para construir possibilidades de ação, na busca por inéditos viáveis. Ao partilhar as experiências do grupo, buscamos contribuir com outros modos de sentir, pensar e fazer a Educação Física EscolaR.
The multidrug resistance transporter P-glycoprotein confers resistance to ferroptosis inducers
Authors: Frye William J. E. , Huff Lyn M. , González Dalmasy José M. , Salazar Paula , Carter Rachel M. , Gensler Ryan T. , Esposito Dominic , Robey Robert W. , Ambudkar Suresh V. , Gottesman Michael M.
Published: July 2023

Aim: Ferroptosis is a non-apoptotic form of cell death caused by lethal lipid peroxidation. Several small molecule ferroptosis inducers (FINs) have been reported, yet little information is available regarding their interaction with the ATP-binding cassette (ABC) transporters P-glycoprotein (P-gp, ABCB1) and ABCG2. We thus sought to characterize the interactions of FINs with P-gp and ABCG2, which may provide information regarding oral bioavailability and brain penetration and predict drug-drug interactions. Methods: Cytotoxicity assays with ferroptosis-sensitive A673 cells transfected to express P-gp or ABCG2 were used to determine the ability of the transporters to confer resistance to FINs; confirmatory studies were performed in OVCAR8 and NCI/ADR-RES cells. The ability of FINs to inhibit P-gp or ABCG2 was determined using the fluorescent substrates rhodamine 123 or purpuin-18, respectively. Results: P-gp overexpression conferred resistance to FIN56 and the erastin derivatives imidazole ketone erastin and piperazine erastin. P-gp-mediated resistance to imidazole ketone erastin and piperazine erastin was also reversed in UO-31 renal cancer cells by CRISPR-mediated knockout of ABCB1. The FINs ML-162, GPX inhibitor 26a, and PACMA31 at 10 µM were able to increase intracellular rhodamine 123 fluorescence over 10-fold in P-gp-expressing MDR-19 cells. GPX inhibitor 26a was able to increase intracellular purpurin-18 fluorescence over 4-fold in ABCG2-expressing R-5 cells. Conclusion: Expression of P-gp may reduce the efficacy of these FINs in cancers that express the transporter and may prevent access to sanctuary sites such as the brain. The ability of some FINs to inhibit P-gp and ABCG2 suggests potential drug-drug interactions.
The Empirical Research of Women Entrepreneurship and Sustainability Performance in the Entrepreneurship Policy Context
Authors: Wu Chih-Wen
Published: July 2023

The research fills the policy research gap for the women entrepreneurship and sustainability performance for examining key successful factors. Previous women entrepreneurship research fails to offer policy recommendations. The research purpose is to investigate these factors affect women entrepreneurship capabilities and sustainability performance by using SEM analysis and making policy recommendation. This research employs online and mail survey and obtains 175 women entrepreneur sample. The study finds that family support and motivation have positive effect on women entrepreneurship capabilities and sustainability performance. Barriers have no effect on performance. Hopefully, the research can provide the guidance to contribute to women’s entrepreneurship opportunities for achieving SDGs. Policy recommendation and managerial implication are discussed in the article.
A Framework of Vehicle Usage Optimization for Tour Purpose
Authors: Sarna Nusrat Jahan , Ahmed Mosnur , Rithen Farzana Ahmed , Islam Motaharul
Published: July 2023

Nowadays, people like to travel to alleviate the stress and depression in their busy lives, and if they can do so at a low cost, it will be even more beneficial to them. The usual way for a traveler to book a ticket or to contact a travel agency is to book a ticket. It becomes more expensive for travelers. Due to the lack of vehicle management, travel agencies don’t get their appropriate profit. In this journal, we have provided proficient solutions for vehicle optimization to minimize travel costs. However, when travelers want to travel, they don’t find a proper tour guide, and it is sometimes expensive to arrange a proper tour guide. Moreover, travelers often don’t find a suitable package, and occasionally they do not know the place where they may want to visit. In this paper, we have discussed how we used effective methods to reduce vehicle costs for tour purposes. Further, we have developed a solution where bus seats are optimally occupied, and the package system and tour guide are included in it. We have also added a blog portal to our web-based software to introduce all tourist places and their information. In this journal, the proposed optimal vehicle usage system has been developed using Hypertext Markup Language (HTML), Cascading Style Sheets (CSS), the Tailwind Framework, React, and Node.js.
Recent advances in nanofiber-based systems for acne treatment: A comprehensive review
Authors: Tören Elçin , Buzgo Matěj
Published: July 2023

Encapsulated nanofibers have emerged as a promising approach for the treatment of acne, owing to their ability to provide controlled release, targeted delivery, increased efficacy, and improved stability. Electrospinning is a well-established method for producing encapsulated nanofibers and has been shown to be effective for encapsulating various active ingredients. However, there are still several challenges that need to be addressed in the development of encapsulated nanofibers for acne treatment. One major challenge is the need for comprehensive in vitro and in vivo studies to evaluate the safety and efficacy of these treatments. The cost and scalability of production also need to be considered to make these treatments accessible and affordable for patients. In addition, the long-term stability of encapsulated active ingredients is another challenge in the development of encapsulated nanofibers for acne treatment. Regulatory frameworks need to be developed to ensure the safety and efficacy of these treatments. Future research may focus on developing multifunctional nanofibers that combine active ingredients with other properties, such as antimicrobial, anti-inflammatory, and wound-healing properties, to provide a comprehensive approach to acne treatment. Moreover, the development of nanofiber-based skincare products may have a significant impact on the cosmetic industry. Overall, while there are still challenges to overcome, the potential benefits of encapsulated nanofibers for acne treatment make them an exciting and promising area of research for the future. In particular, the integration of smart drug delivery systems and responsive materials may enable the development of more personalized and effective treatments for acne. The development of new materials and encapsulation techniques, as well as the exploration of combination therapies that target multiple aspects of acne pathogenesis, are also future perspectives for encapsulated nanofibers in acne treatment.
Exploring the Ways Arabic as a Foreign Language (AFL) Teachers Target Students’ Critical Thinking
Authors: Nfissi Abdelhamid , Elmzandi Jaouhara , Laayadi Soukaina
Published: July 2023

Bloom’s taxonomy was created in 1956 by the educational psychologist Dr. Benjamin Bloom. It was created to promote higher-order thinking skills in the field of education, such as analyzing and evaluating concepts, procedures, and principles, rather than just retrieving facts. As a result, language teachers have access to varied ways to trigger and prompt students’ critical thinking by targeting their higher-order thinking skills. This qualitative research project explores how Moroccan AFL (Arabic as a Foreign Language) teachers target students’ critical thinking. This project focuses on the extent to which Moroccan AFL teachers trigger learners’ higher-order thinking skills, as well as the ways they target them. The research involved the observation of two lessons in a center of teaching Arabic as a foreign language. Three themes emerged from the data and were analysed: First, adopting the role of critical thinking, namely the role of a guide and mediator, not as a teacher of knowledge. Second, using two ways of motivation: positive comments and repeating students' answers. Third, implement activities and questions that help students not to take things for granted.

 

Mengeksplorasi Cara Guru Pelajaran Arab sebagai Bahasa Asing (AFL) Menargetkan Pemikiran Kritis Siswa.Taksonomi Bloom yang diciptakan pada tahun 1956 Benjamin Bloom, psikolog pendidikan, bertujuan untuk mempromosikan keterampilan berpikir tingkat tinggi di bidang pendidikan, seperti menganalisis dan mengevaluasi konsep, prosedur, dan prinsip, bukan hanya mengambil fakta. Akibatnya, guru bahasa memiliki akses ke pelbagai cara untuk memicu dan mendorong pemikiran kritis siswa dengan menargetkan keterampilan berpikir tingkat tinggi mereka. Penelitian kualitatif ini mengeksplorasi bagaimana guru pelajaran Arab sebagai Bahasa Asing (AFL) Maroko menargetkan pemikiran kritis siswa, sehingga penelitian ini terfokus pada sejauh mana guru AFL Maroko memicu keterampilan berpikir tingkat tinggi peserta didik, serta cara mereka menargetkannya. Penelitian ini melibatkan observasi terhadap dua pelajaran di pusat pengajaran bahasa Arab sebagai bahasa asing. Penelitian ini menunjukkan cara seorang guru AFL Maroko menargetkan pemikiran kritis siswa; Pertama, mengadopsi peran berpikir kritis, yaitu peran sebagai pembimbing dan mediator, bukan sebagai guru sumber ilmu. Kedua, menggunakan dua cara motivasi, yaitu penggunaan komentar positif dan pengulangan jawaban peserta didik. Ketiga, menerapkan aktivitas dan pertanyaan yang membantu siswa untuk tidak menerima begitu saja.
Identification of Children's Personality Using Iterative Dichotomizer 3 (ID3) Algorithm
Authors: Sari Amelia Lukita , Rosyid Mochamad Alfan
Published: July 2023

The purpose of this study was to determine the steps of implementing a system to identify the personality of an early childhood and to determine the effect of an early childhood personality identification system on increasing a child's potential to determine their interests and talents. In developing an expert system, the authors use the development method with steps including data collection, analysis, system design, due diligence, program evaluation and implementation. Based on calculations using the ID3 algorithm using the Weka application and manual calculations, it can be seen whether a personality identification is introverted or extroverted. The design of the data classification process is executed to produce a decision tree. From the research based on the research hypothesis, it can be concluded that from the experiments that have been carried out to predict a child's personality using the interactive dichotomous algorithm (ID3) method, predictions can be made to find out a child's personality.
La construcción del espectador desde el texto en cuatro casos de la dramaturgia textual peruana
Authors: Alvarez Carbajal Rita Lucía
Published: July 2023

Hablar del concepto de espectador es entrar en un campo amplio de la recepción. Podemos estudiar su presencia desde distintas aristas, pero normalmente es asociado al hecho escénico, pues su presencia ahí es indispensable. Sin embargo, es posible identificar una construcción del espectador desde la dramaturgia misma. Este trabajo tiene como objetivo identificar la presencia activa y una construcción específica del espectador ideal desde el texto mismo. Para ello, se analizará cuatro casos de la dramaturgia textual peruana desde una mirada semiótica y, en parte, discursiva. De esta manera, podremos notar que la construcción del espectador estará marcada no solo por la existencia de acotaciones que indiquen la ruptura de la cuarta pared, sino por el manejo de un discurso que busque comprometer de manera activa al potencial receptor de la obra, ya sea por la temática tratada o por el peso que le da al rol del espectador para el desarrollo de los hechos.
La presencia de las teorías de Brecht en la formación teatral y en la escena contemporánea como medio para visibilizar la violencia.
Authors: Rodríguez Herrera Raúl Ángel Valentín
Published: July 2023

Buena parte de los programas de estudio de las licenciatura en teatro o actuación están diseñados para formar creadores escénicos que durante su etapa profesional se dedicarán a crear ficciones construidas a partir de textos dramáticos de corte aristotélico. En dichos modelos quedan excluidas otras maneras de articular la creación escénica. Por tal motivo el presente trabajo intenta otorgar mayor protagonismo a las ideas brechtianas, con la finalidad de que el alumnado asuma su creación desde una mayor conciencia estética, ética y política. La intención será impulsar herramientas para que las y los estudiantes, así como creadores y creadoras escénicas, articulen prácticas artísticas que denuncien, critiquen o visibilicen la violencia. Es pertinente que la docencia asuma otras pedagogías acordes a las necesidades de nuestro tiempo, debido a que no podemos seguir replicando modelos de creación que han sido superados por la marcha de la Historia.
Subversión de las marcas de historicidad en la Nueva Novela Histórica Latinoamericana:
Authors: Armas Alcántara Luis Ernesto , Valenzuela Garcés Jorge Antonio
Published: July 2023

El término «marcas de historicidad» fue acuñado por Krzysztof Pomian para establecer la no ficcionalidad del texto histórico. La novela histórica tradicional se apropia de estas «marcas de historicidad» para que su discurso comporte la apariencia de histórico. Por otra parte, la nueva novela histórica latinoamericana, término difundido por Seymour Menton, no solamente se apropiaría de estas «marcas», imitándolas en su forma, sino que, aplicando las características asignadas por Menton, las subvertiría. Este es el objetivo del presente artículo. Para alcanzarlo se utilizó como metodología el análisis del discurso literario presente en el paratexto de Yo el Supremo de Roa Bastos. Se concluyó principalmente que la nueva novela histórica latinoamericana se diferencia de la tradicional en que subvierte las «marcas de historicidad» y esta las imita, que para subvertirlas recurre a la parodia, lo carnavalesco y la anacronía, y que en Yo el Supremo se subvierten estratégicamente afectando su paratexto.
Relación entre el estado nutricional y anemia en niños y niñas de 1 a 5 años beneficiarios del Programa de Vaso de Leche, Cercado de Lima, 2018
Authors:   , Roa Pérez Gessabel Nélida
Published: July 2023

Objetivo: determinar la relación entre el estado nutricional y anemia en los niños y niñas de 1 a 5 años beneficiarios del Programa de Vaso de Leche, Cercado de Lima, 2018. Materiales y métodos: estudio descriptivo, correlacional y transversal. La población estuvo constituida por los niños y niñas entre 1 a 5 años beneficiarios del Programa Vaso de Leche en el distrito de Cercado de Lima en el 2018. Se realizó un muestreo probabilístico estratificado y la técnica de muestreo aleatorio estratificado; seleccionándose 350 niños entre 1 a 5 años. La medición de la hemoglobina se realizó mediante la punción capilar y se utilizó un hemoglobinómetro; el estado nutricional de los niños se determinó según los parámetros antropométricos de la OMS: P/T, T/E y P/E. Se utilizó la prueba Chi cuadrado de Pearson (X2) con un nivel de significancia α=0,05 mediante programa SPSS versión 22.0. Resultados: El estado nutricional en los estudiados según el indicador P/T, muestra que el 78.3% se encuentra normal, el 12% está con sobrepeso, el 6% con obesidad y con desnutrición aguda el 3.7%. Según el indicador P/E, muestra que el 80.6% se encuentra normal, el 10.9% está con desnutrición y el 8.5% con sobrepeso. Según el indicador T/E muestra que el 97.4% se encuentra normal, el 2% presentó talla baja y el 0.6% talla alta. La prevalencia de anemia alcanzó al 57.1%, según el grado de anemia, el 45.4% de los niños presentó anemia leve y anemia moderada; el 2.3% anemia severa. Conclusión: Existe relación significativa (p: 0.019, α=0,05) entre el estado nutricional y anemia en niños y niñas de 1 a 5 años beneficiarios del Programa de Vaso de Leche en Cercado de Lima en el 2018.
IADC Code Upgrade: Interpretation of Surface and Downhole Data to Support Drilling Forensics
Authors: Watson W. , Witt-Doerring Y. , Sugiura J. , Pastusek P. , Daechsel D. , Vallet L. , Amish M. , Oluyemi G.
Published: July 2023

This paper establishes drilling surveillance interpretation and monitoring techniques for digital drilling data which can be used to support drilling forensics and improve drilling performance.

One significant advancement in the last 20 years has been the widespread availability and use of sensors to monitor all aspects of the drilling process. The majority of sensors will take surface and downhole data at several hundred samples per second, process the data, and store a record at one sample per second. The data from these sensors are collated and processed using some form of electronic data recording (EDR) system. The information is subsequently displayed in real time and stored for off-site transmittal. This paper extensively evaluates the impact on drilling performance due to how data from such sensors are collected and processed and the information is displayed.

A number of observations are investigated, analyzed, and explained identifying how data quality, consistency, frequency, sensor errors, and data artifacts can skew the displayed results. This can critically impact the drilling forensic analysis and subsequent interpretation. Failing to account for these data quality issues in real time may mask drilling dysfunction, causing accelerated damage to the drill bit and drilling assembly. This paper also aims to highlight techniques for displaying and interpreting drilling data to enhance drilling performance as well as diagnose dysfunction during reviews of historic wells. Understanding these limitations in advance and incorporating them in a team’s surveillance strategy can help with the diagnosis of drilling dysfunction and aid performance improvement.

These recommended practices have been developed to offer a foundation for drilling surveillance, interpretation, and monitoring as well as training for the industry. They have been created such that they can grow organically and may be used for developing subsequent industry publications.

The work described in this paper is part of a joint International Association of Drilling Contactors (IADC)/Society of Petroleum Engineers (SPE) industry effort to revise the IADC dull-grade process.
Antidepressant mechanism of Guipi Decoction revealed by network pharmacology and molecular docking
Authors: Wei Fangyuan , Song Jianxin , Pan Xiaoya , Zhang Xiangrong Dr.
Published: July 2023

Guipi Decoction is a famous Traditional Chinese Medicine formulae, which can be used to treat insomnia and depression. But its specific mechanism is still unclear. In this study, the active ingredients, targets and mechanisms of the Ziziphi Spinosae Semen-Poria cocos-Longan (ZPL) in Guipi Decocation was investigated by network pharmacology analysis and molecular docking. A total of 32 active ingredients, 344 intersection targets and 13 key targets were obtained. The result showed (S)-Coclaurine, coumestrol, n-trans-feruloyltyramine, ellagic acid, ellipticine and tartaric acid were the key compounds for depression. These compositions could reduce inflammatory response, inhibit pro-inflammatory cytokines, reduce neuronal apoptosis, and then modulate depression by the key targets of RAC-alpha serine/threonine-protein kinase (AKT1), tumor necrosis factor (TNF), interleukin (IL6), mitogen activated protein kinase 3 (MAPK3). Molecular docking results showed that the binding energy of n-trans-feruloyltyramine with PPARG was the lowest, -9.513 kcal/mol and the binding energy of (S)-Coclaurine and ESR1 was − 9.336. Upregulation of AKT1 gene inhibits apoptosis. Downregulation of TNF-α, MAPK and CTNNB1 genes reduces the expression of inflammatory factors and decreases the inflammatory response, which plays an important role in the treatment of depression. In conclusion, the active component of ZPL binds stably with AKT1, MAPK3, ESR1 and CTNNB1 and controlled the onset of depression by regulation of genes expression.
Effect of using drug management application on drug adherence and outcomes in older adults with polypharmacy: a randomized clinical trial study
Authors: Poorcheraghi Hossein , negarandeh reza , pashaeypoor shahzad , jorian Javad
Published: July 2023

Background
Adherence to complex drug regimens and polypharmacy are among the challenges of old age, which may negatively affect their motivation to continue drug therapy or lead to incorrect drug administration. The present study was conducted to evaluate the effect of using a drug management application on drug adherence and outcomes in polypharmacy older adults.
Methods
In this randomized clinical trial study conducted in 2022, 192 Iranian older adults with polypharmacy were selected according to the inclusion criteria and allocated to case and control groups using the block randomization method. The data collection tools included a demographic questionnaire, drug outcome questionnaire, and Morisky Medication Adherence Scale. The intervention was done using a drug management application for 8 weeks. The collected data were entered into the SPSS software version 22 and analyzed using descriptive (frequency, percentage, mean, standard deviation) and inferential (Chi-square, Fisher’s exact test, independent t-test) statistics.
Results
The case and control groups were homogeneous in terms of demographic variables and drug adherence level before the intervention. A significant difference was found in the drug adherence level after using the app (p < 0.001). Moreover, a significant difference was found in drug outcomes, including re-hospitalization due to disease aggravation, re-hospitalization due to medication error, falling, hypo or hypertension, and hypo or hyperglycemia, and medication use accuracy between the groups after the intervention (p < 0.05).
Conclusion
The results showed that using a drug management application that meets the specifications of older adults can improve drug adherence and reduce the adverse outcomes of drug use.
Brachial Plexopathy and Horner Syndrome as Presenting Symptoms for Non-Hodgkin’s Lymphoma
Authors: Labbad Ibrahim , Yasmeeneh Abeer , Mardini Majd , Abdulaziz Osama , Hamzeh Ghassan
Published: July 2023

Background:
the neurologic symptoms that appear due to paraneoplastic syndrome may give manifestations of undiagnosed tumor, but in this case brachial plexopathy accompanied with Horner syndrome were the first manifestations of non-Hodgkin lymphoma as paraneoplastic syndromes that preceded the diagnosis of the disease by about two years.
Case presentation:
in this case we report a 27 years old man who suffered from severe pain and weakness in the right upper limb, accompanied with right Horner syndrome.
Clinical discussion:
at the beginning of his complaint all the laboratory and radiographic investigations; CT scan, MRI for cervical spine and brachial plexus were negative except for the presence of marked thickening of the trunks, roots, and cords of the right brachial plexus that enhanced with gadolinium injection, after few months his symptoms developed include difficulty swallowing and hoarseness and lower extremities weakness, whole-body FDG-PET imaging was performed and showed right side cervical vertebral ganglia at the level of second and third vertebrae which was biopsied and showed: Diffuse large B-cell non-Hodgkin’s lymphoma. He began with treatment to which the tumor responded well.
Conclusion:
patients with brachial plexopathy, Horner syndrome, cervical spine myelopathy and peripheral neuropathy as manifestations for paraneoplastic syndrome of non-Hodgkin lymphoma are very rare and maybe this is the first case in worldwide.