bluuebunny/crossref_metadata_2025 huggingface dataset:
Mitotic Chromosomes in Live Cells Characterized Using High-Speed and Label-Free Optical Diffraction Tomography
Authors: Kim Tae-Keun , Lee Byong-Wook , Fujii Fumihiko , Lee Kee-Hang , Lee Sanghwa , Park YongKeun , Kim Jun Ki , Lee Sang-Wook , Pack Chan-Gi
Published: November 2019

The cell nucleus is a three-dimensional, dynamic organelle organized into subnuclear compartments such as chromatin and nucleoli. The structure and function of these compartments are maintained by diffusion and interactions between related factors as well as by dynamic and structural changes. Recent studies using fluorescent microscopic techniques suggest that protein factors can access and are freely mobile in heterochromatin and in mitotic chromosomes, despite their densely packed structure. However, the physicochemical properties of the chromosome during cell division are not fully understood. In the present study, characteristic properties such as the refractive index (RI), volume of the mitotic chromosomes, and diffusion coefficient (D) of fluorescent probes inside the chromosome were quantified using an approach combining label-free optical diffraction tomography with complementary confocal laser-scanning microscopy and fluorescence correlation spectroscopy. Variations in these parameters correlated with osmotic conditions, suggesting that changes in RI are consistent with those of the diffusion coefficient for mitotic chromosomes and cytosol. Serial RI tomography images of chromosomes in live cells during mitosis were compared with three-dimensional confocal micrographs to demonstrate that compaction and decompaction of chromosomes induced by osmotic change were characterized by linked changes in chromosome RI, volume, and the mobilities of fluorescent proteins.
Function of Nr4a Orphan Nuclear Receptors in Proliferation, Apoptosis and Fuel Utilization Across Tissues
Authors: Herring Jacob A. , Elison Weston S. , Tessem Jeffery S.
Published: November 2019

The Nr4a family of nuclear hormone receptors is composed of three members—Nr4a1/Nur77, Nr4a2/Nurr1 and Nr4a3/Nor1. While currently defined as ligandless, these transcription factors have been shown to regulate varied processes across a host of tissues. Of particular interest, the Nr4a family impinge, in a tissue dependent fashion, on cellular proliferation, apoptosis and fuel utilization. The regulation of these processes occurs through both nuclear and non-genomic pathways. The purpose of this review is to provide a balanced perspective of the tissue specific and Nr4a family member specific, effects on cellular proliferation, apoptosis and fuel utilization.
Assessment of Pediatric Residents’ Attitudes toward Anticipatory Counseling on Gun Safety
Authors: Juang Daon D. , McDonald Diane L. , Johnson-Young Elizabeth A. , Burrell Tierra D. , Silver Dana L. , Wang Yan , Lichenstein Richard
Published: November 2019

Introduction: Guns remain a major cause of injury and death among children. We determined pediatric residents’ familiarity with gun safety campaigns and their gun safety counseling practices. We determined pediatric residents’ comfort with the Asking Saves Kids (ASK) campaign, which recommends that parents ask about gun safety and storage where their children play. Methods: Cross-sectional 27-item electronic survey was distributed to three pediatric residency programs in Baltimore, Maryland, USA. Residents were asked to respond to statements using a seven-point Likert scale on familiarity with three gun safety campaigns and their attitudes toward gun safety counseling. Results: 82% of respondents were not familiar with gun safety programs. 23% reported not counseling. 87% believed it is a good idea to ask about guns in a home but only 64% were comfortable recommending their patients’ parents to ask about guns. 59% were personally comfortable asking about guns in the home. 15% believed their patients’ parents would be comfortable asking about guns in the homes of friends and families. Conclusions: The residents in this survey supported the idea of gun safety anticipatory guidance but discussing firearms can be problematic. Educational programs and strategies are needed to support physicians’ counselling on gun safety.
Fabrication of Fe3O4@SiO2 Nanofluids with High Breakdown Voltage and Low Dielectric Loss
Authors: Du Bin , Shi Yu , Liu Qian
Published: November 2019

Insulating oil modified by nanoparticle (often called nanofluids) has recently drawn considerable attention, especially concerning the improvement of electrical breakdown and thermal conductivity of the nanofluids. However, traditional insulating nanofluid often tends to high dielectric loss, which accelerates the ageing of nanofluids and limits its application in electrical equipment. In this paper, three core-shell Fe3O4@SiO2 nanoparticles with different SiO2 shell thickness were prepared and subsequently dispersed into insulating oil to achieve nanofluids. The dispersion stability, breakdown voltages and dielectric properties of these nanofluids were comparatively investigated. Experimental results show the alternating current (AC) and positive lightning breakdown voltage of nanofluids increased by 30.5% and 61%, respectively. Moreover, the SiO2 shell thickness of Fe3O4@SiO2 nanoparticle had significant effects on the dielectric loss of nanofluids.
Research on Distribution Properties of Coating Film Thickness from Air Spraying Gun-Based on Numerical Simulation
Authors: Xie Xiaopeng , Wang Yinan
Published: November 2019

This work aims to study the influence of the spraying parameters on the spray flow field and coating thickness distribution during the air spraying process. The shaping air pressure and the target geometry have an important influence on the distribution of coating film thickness. This paper begins with a 3-D physical model of an air spray gun, in which unstructured grids were generated for control domain. A grid independency study was also carried out to determine the optimal number of cells for the simulations. Then the Euler–Lagrange method was used to describe the two-phase spray flow by establishing a paint deposition model. The numerical simulation based on the discrete phase model (DPM) and TAB model has been carried out. A reasonable assumption was proposed based on the analysis of the spraying process, so that the droplets were injected into the airflow at the position of the paint hole. The influence of the shaping air pressure on the air flow field and the coating thickness distribution was analyzed by changing the shaping air pressure. From the numerical simulation results, it can be concluded that the smaller the shaping air pressure, the more concentrated the coating. With increasing the shaping air pressure, the length of the coating film along z-axis gradually increases, the width along x-axis gradually decreases, and the spray area gradually increases. The paper ends with a numerical simulation and experimental study on planar vertical spraying, planar tilted spraying, and cylinder spraying. Comparisons and experiment results verify the validity and practicability of the model built in this paper.
Mangrove Inspired Anti-Corrosion Coatings
Authors: Cui Miaomiao , Wang Peng-Yuan , Wang Zuankai , Wang Bin
Published: November 2019

Marine corrosion accounts for one-third of the total corrosion cost and has been one of the greatest challenges for modern society. Organic coatings are known as the most widely used protective means. An effective control of the transport of corrosive substances is the key to the anti-corrosion performance. In nature, the mangrove survives and thrives in marine tidal zones despite high salinity and humidity. We first showed that the mangrove leaves have salt glands that can secrete excessive ions to control the ion transport in and out. Inspired by this, we proposed a design of bio-inspired, anti-corrosion coating that mimics this functional feature, and fabricated the bipolar, hydrophobic coatings by doping ion-selective resins and constructing surface structures, which restrict the transport of corrosive substances and the electrochemical corrosion at the coating/metal interface. Our results show that the bio-inspired coatings effectively block and control the transport of both the Na+ and Cl−, and, together with the hydrophobic surface, the coating system exhibits significantly improved anti-corrosion properties, more than a three orders of magnitude decrease in corrosion current density when compared with the control group (epoxy varnish). Therefore, the mangrove-inspired coatings show a promising protective strategy for the ever-demanding corrosion issues plaguing modern industries.
Aquatic Macrophytes are Seasonally Important Dietary Resources for Moose
Authors: Tischler Keren B. , Severud William J. , Peterson Rolf O. , Bump Joseph K.
Published: November 2019

Moose (Alces alces) are generalist herbivores, but are important aquatic-terrestrial ecotone specialists. Aquatic macrophytes are a high-quality food source for moose during summer, but the importance of aquatic food sources to the moose diet is difficult to study. We used stable isotope analysis of carbon and nitrogen from moose hooves and forage (terrestrial plants, aquatic macrophytes, and arboreal lichen) to assess the diet of moose at Isle Royale National Park, Michigan, USA, using Bayesian mixing models. We also evaluated the isotopic variability along chronologies of serially sampled hooves. Overall, our mixing models indicate that 13%–27% of the summer moose diet was aquatic in origin. Among moose that died during winter, body condition was impaired and hoof δ15N was higher where aquatic habitats were sparse. Although isotope chronologies preserved in hooves could significantly enhance our understanding of ungulate foraging ecology, interpretation of such chronologies is presently limited by our lack of knowledge pertaining to hoof growth rate and seasonal growth variability related to age and health. Distinct isotopic values among terrestrial plants, aquatic macrophytes, and arboreal lichens indicate that continued methodological advances in stable isotope ecology will lead to more precise estimates of the contribution of aquatic feeding to moose population dynamics and other ungulates.
Advanced Heart Failure and End-Stage Heart Failure: Does a Difference Exist
Authors: Severino Paolo , Mather Paul J. , Pucci Mariateresa , D’Amato Andrea , Mariani Marco Valerio , Infusino Fabio , Birtolo Lucia Ilaria , Maestrini Viviana , Mancone Massimo , Fedele Francesco
Published: November 2019

Advanced heart failure (AdHF) represents a challenging aspect of heart failure patients. Because of worsening clinical symptoms, high rates of re-hospitalization and mortality, AdHF represents an unstable condition where standard treatments are inadequate and additional interventions must be applied. A heart transplant is considered the optimal therapy for AdHF, but the great problem linked to the scarcity of organs and long waiting lists have led to the use of mechanical circulatory support with ventricular-assist device (VAD) as a destination therapy. VAD placement improves the prognosis, functional status, and quality of life of AdHF patients, with high rates of survival at 1 year, similar to transplant. However, the key element is to select the right patient at the right moment. The complete assessment must include a careful clinical evaluation, but also take into account psychosocial factors that are of crucial importance in the out-of-hospital management. It is important to distinguish between AdHF and end-stage HF, for which advanced therapy interventions would be unreasonable due to severe and irreversible organ damage and, instead, palliative care should be preferred to improve quality of life and relief of suffering. The correct selection of patients represents a great issue to solve, both ethically and economically.
Acute Bronchiolitis: Is There a Role for Lung Ultrasound?
Authors: Di Mauro Antonio , Ammirabile Angela , Quercia Michele , Panza Raffaella , Capozza Manuela , Manzionna Mariano M. , Laforgia Nicola
Published: November 2019

Introduction: Viral bronchiolitis is a common cause of lower respiratory tract infection in the first year of life, considered a health burden because of its morbidity and costs. Its diagnosis is based on history and physical examination and the role of radiographic examination is limited to atypical cases. Thus far, Lung Ultrasound (LUS) is not considered in the diagnostic algorithm for bronchiolitis. Methods: PubMed database was searched for trials reporting on lung ultrasound examination and involving infants with a diagnosis of bronchiolitis. Results: Eight studies were suitable. Conclusions: This review analyzed the current evidence about the potential usefulness of LUS in the clinical management of bronchiolitis. Literature supports a peculiar role of LUS in the evaluation of the affected children, considering it as a reliable imaging test that could benefit the clinical management of bronchiolitis.
Getting Past the Gateway: An Exploratory Case on Using Utilitarian Scientific Literacy to Support First-Year Students At-Risk of Leaving STEM
Authors: Chambers Brittany , Salter Amy , Muldrow Lycurgus
Published: November 2019

First-year students who enter college pursuing a STEM degree still face challenges persisting through the STEM pipeline (Chen, 2013; Leu, 2017). In this case study, researchers examine the impact of a utilitarian scientific literacy based academic intervention on retention of first-year students in STEM using a mixed methods approach. A sample (n = 116) of first-year students identified as at-risk of not persisting in STEM were enrolled in a for credit utilitarian scientific literacy course. Participants of the semester long course were then compared with a control group of first-year students identified as at-risk of persisting in STEM. A two-proportion z test was performed to assess the mean differences between students and participants of the course were given a survey to gauge student experiences. Quantitative results (φ 0.34, p < 0.05) indicate that the utilitarian scientific literacy course had a statistically significant impact on retention among first-year students at-risk of persisting in STEM. Moreover, qualitative data obtained from participant responses describe internal and external growth as positive outcomes associated with the intervention.
LDMOS versus GaN RF Power Amplifier Comparison Based on the Computing Complexity Needed to Linearize the Output
Authors: Gracia Sáez Raúl , Medrano Marqués Nicolás
Published: November 2019

In order to maximize the efficiency of telecommunications equipment, it is necessary that the radio frequency (RF) power amplifier is situated as closely as possible to its compression point. This makes its response nonlinear, and therefore it is necessary to linearize it, in order to minimize the interference that nonlinearities cause outside the useful band (adjacent channel). The system used for this linearization occupies a high percentage of the hardware and software resources of the telecommunication equipment, so it is interesting to minimize its complexity in order to make it as simple as possible. This paper analyzes the differences between the laterally diffused MOSFET (LDMOS) and gallium nitride (GaN) power amplifiers, in terms of their nonlinearity graphs, and in terms of the greater or lesser difficulty of linearization. A correct choice of power amplifier will allow for minimization of the linearization system, greatly simplifying the complexity of the final design.
Contribution to the Channel Path Loss and Time-Dispersion Characterization in an Office Environment at 26 GHz
Authors: Rubio Lorenzo , Torres Rafael P. , Rodrigo Peñarrocha Vicent M. , Pérez Jesús R. , Fernández Herman , Molina-Garcia-Pardo Jose-Maria , Reig Juan
Published: November 2019

In this paper, path loss and time-dispersion results of the propagation channel in a typical office environment are reported. The results were derived from a channel measurement campaign carried out at 26 GHz in line-of-sight (LOS) and obstructed-LOS (OLOS) conditions. The parameters of both the floating-intercept (FI) and close-in (CI) free space reference distance path loss models were derived using the minimum-mean-squared-error (MMSE). The time-dispersion characteristics of the propagation channel were analyzed through the root-mean-squared (rms) delay-spread and the coherence bandwidth. The results reported here provide better knowledge of the propagation channel features and can be also used to design and evaluate the performance of the next fifth-generation (5G) networks in indoor office environments at the potential 26 GHz frequency band.
Comparing the Effectiveness of Scratch and App Inventor with Regard to Learning Computational Thinking Concepts
Authors: Park Youngki , Shin Youhyun
Published: November 2019

Scratch and App Inventor are two of the most widely used block-based programming languages for young students. These are educational languages which allow students to program easily by dragging and dropping their code blocks. One question that arises in relation to these educational languages is which of them would be more helpful in fostering computational thinking. It is difficult to answer this question because each language has its own advantages. In this paper, we propose a novel rubric based on Dr. Scratch for assessing both Scratch and App Inventor projects in terms of computational thinking concept learning. We crawled teachers’ and students’ open and popular projects and automatically calculated their effectiveness scores with regard to learning computational thinking concepts based on our rubric. The experimental results show that (1) Scratch projects scored higher on average in Parallelism, Synchronization and Flow Control, while App Inventor projects scored higher on average in User Interactivity and Data Representation. The results also show that (2) in many cases, large programs with numerous lines of code scored high in all areas of computational thinking concepts.
A Novel Hybrid Converter Proposed for Multi-MW Wind Generator for Offshore Applications
Authors: Luqman Muhammad , Yao Gang , Zhou Lidan , Zhang Tao , Lamichhane Anil
Published: November 2019

Modern multi-MW wind generators have used multi-level converter structures as well as parallel configuration of a back to back three-level neutral point clamped (3L-NPC) converters to reduce the voltage and current stress on the semiconductor devices. These configurations of converters for offshore wind energy conversion applications results in high cost, low power density, and complex control circuitry. Moreover, a large number of power devices being used by former topologies results in an expensive and inefficient system. In this paper, a novel bi-directional three-phase hybrid converter that is based on a parallel combination of 3L-NPC and ‘n’ number of Vienna rectifiers have been proposed for multi-MW offshore wind generator applications. In this novel configuration, total power equally distributes by sharing of total reference current in each parallel-connected generator side power converter, which ensures the lower current stress on the semiconductor devices. Newly proposed topology has less number of power devices compared to the conventional configuration of parallel 3L-NPC converters, which results in cost-effective, compact in size, simple control circuitry, and good performance of the system. Three-phase electric grid is considered as a generator source for implementation of a proposed converter. The control scheme for a directly connected three-phase source with a novel configuration of a hybrid converter has been applied to ratify the equal power distribution in each parallel-connected module with good power factor and low current distortion. A parallel combination of a 3L-NPC and 3L-Vienna rectifier with a three-phase electric grid source has been simulated while using MATLAB and then implemented it on hardware. The simulation and experimental results ratify the performance and effectiveness of the proposed system.
A Multi-Step Approach to Modeling the 24-hour Daily Profiles of Electricity Load using Daily Splines
Authors: Jornaz Abdelmonaem , Samaranayake V. A.
Published: November 2019

Forecasting of real-time electricity load has been an important research topic over many years. Electricity load is driven by many factors, including economic conditions and weather. Furthermore, the demand for electricity varies with time, with different hours of the day and different days of the week having an effect on the load. This paper proposes a hybrid load-forecasting method that combines classical time series formulations with cubic splines to model electricity load. It is shown that this approach produces a model capable of making short-term forecasts with reasonable accuracy. In contrast to forecasting models that utilize a multitude of regressor variables observed at multiple time points within a day, only the hourly temperature is used in the proposed model and predictive power gains are achieved through the modeling of the 24-hour load profiles across weekends and weekdays while also taking into consideration seasonal variations of such profiles. Long-term trends are accounted for by using population and economic variables. The proposed approach can be used as a stand-alone predictive platform or be used as a scaffolding to build a more complex model involving additional inputs. The data cover the period from 1 January 1993 through 31 December 2013 from the Atlantic City Electric zone.
Multi-Level Modeling Methodology for Optimal Design of Electric Machines Based on Multi-Disciplinary Design Optimization
Authors: Dai Zehua , Wang Li , Meng Lexuan , Yang Shanshui , Mao Ling
Published: November 2019

The transportation sector is undergoing electrification to gain advantages such as lighter weight, improved reliability, and enhanced efficiency. As contributors to the safety of embedded critical functions in electrified systems, better sizing of electric machines in vehicles is required to reduce the cost, volume, and weight. Although the designs of machines are widely investigated, existing studies are mostly complicated and application-specific. To satisfy the multi-level design requirements of power systems, this study aims to develop an efficient modeling method of electric machines with a background of aircraft applications. A variable-speed variable-frequency (VSVF) electrically excited synchronous generator is selected as a case study to illustrate the modular multi-physics modeling process, in which weight and power loss are the major optimization goals. In addition, multi-disciplinary design optimization (MDO) methods are introduced to facilitate the optimal variable selection and simplified model establishment, which can be used for the system-level overall design. Several cases with industrial data are analyzed to demonstrate the effectiveness and superior performance of the modeling method. The results show that the proposed practices provide designers with accurate, fast, and systematic means to develop models for the efficient design of aircraft power systems.
An Energy-Efficient and Secure Routing Protocol for Intrusion Avoidance in IoT-Based WSN
Authors: Haseeb Khalid , Almogren Ahmad , Islam Naveed , Ud Din Ikram , Jan Zahoor
Published: November 2019

Due to the advancement of information and communication technologies, the use of Internet of Things (IoT) devices has increased exponentially. In the development of IoT, wireless sensor networks (WSNs) perform a vital part and comprises of low-cost smart devices for information gathering. However, such smart devices have constraints in terms of computation, processing, memory and energy resources. Along with such constraints, one of the fundamental challenges for WSN is to achieve reliability with the security of transmitted data in a vulnerable environment against malicious nodes. This paper aims to develop an energy-efficient and secure routing protocol (ESR) for intrusion avoidance in IoT based on WSN to increase the network period and data trustworthiness. Firstly, the proposed protocol creates different energy-efficient clusters based on the intrinsic qualities of nodes. Secondly, based on the (k,n) threshold-based Shamir secret sharing scheme, the reliability and security of the sensory information among the base station (BS) and cluster head are achieved. The proposed security scheme presents a light-weight solution to cope with intrusions generated by malicious nodes. The experimental results using the network simulator (NS-2) demonstrate that the proposed routing protocol achieved improvement in terms of network lifetime as 37%, average end-to-end delay as 24%, packet delivery ratio as 30%, average communication cost as 29%, network overhead as 28% and the frequency of route re-discoveries as 38% when compared with the existing work under dynamic network topologies.
Prospects for Hermetic Sealing of Scaled-Up Photoelectrochemical Hydrogen Generators for Reliable and Risk Free Operation
Authors: Calnan Sonya , Aschbrenner Stefan , Bao Fuxi , Kemppainen Erno , Dorbandt Iris , Schlatmann Rutger
Published: November 2019

Photo-electrochemical (PEC) systems have the potential to contribute to de-carbonation of the global energy supply because solar energy can be directly converted to hydrogen, which can be burnt without the release of greenhouse gases. However, meaningful deployment of PEC technology in the global energy system, even when highly efficient scaled up devices become available, shall only be a reality when their safe and reliable operation can be guaranteed over several years of service life. The first part of this review discusses the importance of hermetic sealing of up scaled PEC device provided by the casing and sealing joints from a reliability and risk perspective. The second part of the review presents a survey of fully functional devices and early stage demonstrators and uses this to establish the extent to which the state of the art in PEC device design address the issue of hermetic sealing. The survey revealed that current material choices and sealing techniques are still unsuitable for scale–up and commercialization. Accordingly, we examined possible synergies with related photovoltaic and electrochemical devices that have been commericalised, and derived therefrom, recommendations for future research routes that could accelerate the development of hermetic seals of PEC devices.
Switch for the Optimization of Module Power by Reconfiguration of All Strings (SOMBRA): An Insulated Integrated Switch for a Reconfigurable Solar Panel
Authors: Bauwens Pieter , Doutreloigne Jan
Published: November 2019

The energy yield of a solar panel can be severely impacted by partial shading. Shade caused by nearby static objects can hardly be avoided in installations such as building-applied or building-integrated photovoltaics. Smart reconfigurable photovoltaics (PV) panels are able to change their intra-module configuration to reduce this impact: small substrings can be rewired to be connected in a more optimal configuration. To achieve this, a reconfiguration switch needs to be designed. In this paper a switch for the optimization of module power by reconfiguration of all strings (SOMBRA), a smart switch, is presented. SOMBRA is a fully integrated, low-ohmic switch, designed for currents up to 10 A. It is fully floating up to 50 V, while still being able to communicate with a central unit as an inter-integrated circuit (I 2 C) slave. Two versions were realized, SOMBRA-LV10 for low voltages (LV) and a load current of 10 A, and SOMBRA-HV05 for high voltages (HV) and a load current of 5 A. Measurements proved these devices to be functional, measuring an on-resistance of 1.3 m Ω for SOMBRA-LV10 and 7.3 m Ω for SOMBRA-HV05. This paper will elaborate on the operation, design, and implementation of SOMRBA, as well as the first tests with a small reconfigurable PV module.
A Novel Prediction Approach for Short-Term Renewable Energy Consumption in China Based on Improved Gaussian Process Regression
Authors: Huang Yuansheng , Yang Lei , Gao Chong , Jiang Yuqing , Dong Yulin
Published: November 2019

Energy consumption issues are important factors concerning the achievement of sustainable social development and also have a significant impact on energy security, particularly for China whose energy structure is experiencing a transformation. Construction of an accurate and reliable prediction model for the volatility changes in energy consumption can provide valuable reference information for policy makers of the government and for the energy industry. In view of this, a novel improved model is developed in this article by integrating the modified state transition algorithm (MSTA) with the Gaussian processes regression (GPR) approach for non-fossil energy consumption predictions for China at the end of the 13th Five-Year Project, in which the MSTA is utilized for effective optimization of hyper-parameters in GPR. Aiming for validating the superiority of MSTA, several comparisons are conducted on two well-known functions and the optimization results show the effectiveness of modification in the state transition algorithm (STA). Then, based on the latest statistical renewable energy consumption data, the MSTA-GPR model is utilized to generate consumption predictions for overall renewable energy and each single renewable energy source, including hydropower, wind, solar, geothermal, biomass and other energies, respectively. The forecasting results reveal that the proposed improved GPR can promote the forecasting ability of basic GPR and obtain the best prediction effect among all the other comparison models. Finally, combined with the forecasting results, the trend of each renewable energy source is analyzed.
Data Centers as Active Multi-Energy Systems for Power Grid Decarbonization: A Technical and Economic Analysis
Authors: Lombardi Pio Alessandro , Moreddy Kranthi Ranadheer , Naumann André , Komarnicki Przemyslaw , Rodio Carmine , Bruno Sergio
Published: November 2019

Power system decarbonization will be one of the main challenges confronting society over the next twenty to thirty years. Renewable energy sources (RES), such as wind and solar, will be the main resources supplying the power grid. Given their volatility, their integration into the grid necessitates planning and utilizing new flexibility options. Energy storage systems (ESS), multi-energy systems and active consumer involvement are three solutions attracting the scientific community’s attention. Data centers (DCs) provide a very high degree of flexibility for consumers. They can be utilized to support system operators or integrate power generated by locally installed renewable energy source generators in the DC’s network. This study is intended to contribute by developing a methodology for planning new flexibility options in DCs. The methodology developed treats DCs as active multi-energy systems. Control strategies were also developed. The technical and economic performance of the solutions implemented was evaluated.
Tree Species Classification by Integrating Satellite Imagery and Topographic Variables Using Maximum Entropy Method in a Mongolian Forest
Authors: Chiang Shou-Hao , Valdez Miguel
Published: November 2019

Forests are an important natural resource that achieve ecological balance by regulating water regimes and promoting soil conservation. Based on forest inventories, the government is able to make decisions to sustainably conserve, improve, and manage forests. Fieldwork for forestry investigation requires intensive physical labor, which is costly and time-consuming, especially for surveys in remote mountainous regions. Remote sensing technology has been recently used for forest investigation on a large scale. An informative forest inventory must include forest attributes, including details of tree species; however, tree species mapping is not always applicable due to the similarity of surface reflectance and texture between tree species. Topographic variables such as elevation, slope, aspect, and curvature are crucial in allocating ecological niches to different species; therefore, this study suggests that integrating topographic information and optical satellite image classification can improve mapping accuracy for tree species. The main purpose of this study is to classify forest tree species in Erdenebulgan County, Huwsgul Province, Mongolia, by integrating Landsat satellite imagery with a Digital Elevation Model (DEM) using a Maximum Entropy algorithm. A forest tree species inventory from the Forest Division of the Mongolian Ministry of Nature and Environment was used as training data and as ground truth to perform the accuracy assessment. In this study, the classification was made using two different experimental approaches. First, classification was done using only Landsat surface reflectance data; and second, topographic variables were integrated with the Landsat surface reflectance data. The integration approach showed a higher overall accuracy and kappa coefficient, indicating that an accurate forest inventory can be achieved by integrating satellite imagery data and other topographic information to enhance the practice of forest management in remote regions.
Natural Convection in a Non-Newtonian Fluid: Effects of Particle Concentration
Authors: Tao Chengcheng , Wu Wei-Tao , Massoudi Mehrdad
Published: November 2019

In this paper we study the buoyancy driven flow of a particulate suspension between two inclined walls. The suspension is modeled as a non-linear fluid, where the (shear) viscosity depends on the concentration (volume fraction of particles) and the shear rate. The motion of the particles is determined by a convection-diffusion equation. The equations are made dimensionless and the boundary value problem is solved numerically. A parametric study is performed, and velocity, concentration and temperature profiles are obtained for various values of the dimensionless numbers. The numerical results indicate that due to the non-uniform shear rate, the particles tend to concentrate near the centerline; however, for a small Lewis number (Le) related to the size of the particles, a uniform concentration distribution can be achieved.
The RB1 Story: Characterization and Cloning of the First Tumor Suppressor Gene
Authors: Berry Jesse L. , Polski Ashley , Cavenee Webster K. , Dryja Thaddeus P. , Murphree A. Linn , Gallie Brenda L.
Published: November 2019

The RB1 gene is the first described human tumor suppressor gene and plays an integral role in the development of retinoblastoma, a pediatric malignancy of the eye. Since its discovery, the stepwise characterization and cloning of RB1 have laid the foundation for numerous advances in the understanding of tumor suppressor genes, retinoblastoma tumorigenesis, and inheritance. Knowledge of RB1 led to a paradigm shift in the field of cancer genetics, including widespread acceptance of the concept of tumor suppressor genes, and has provided crucial diagnostic and prognostic information through genetic testing for patients affected by retinoblastoma. This article reviews the long history of RB1 gene research, characterization, and cloning, and also discusses recent advances in retinoblastoma genetics that have grown out of this foundational work.
Identification of an Embryonic Cell-Specific Region within the Pineapple SERK1 Promoter
Authors: Luan Aiping , He Yehua , Xie Tao , Chen Chengjie , Mao Qi , Wang Xiaoshuang , Li Chuhao , Ding Yaqi , Lin Wenqiu , Liu Chaoyang , Xia Jingxian , He Junhu
Published: November 2019

Plant tissue culture methods, such as somatic embryogenesis, are attractive alternatives to traditional breeding methods for plant propagation. However, they often suffer from limited efficiency. Somatic embryogenesis receptor kinase (SERK)1 is a marker gene of early somatic embryogenesis in several plants, including pineapple. It can be selectively induced and promotes a key step in somatic embryogenesis. We investigated the embryonic cell-specific transcriptional regulation of AcSERK1 by constructing a series of vectors carrying the GUS (Beta-glucuronidase) reporter gene under the control of different candidate cis-regulatory sequences. These vectors were transfected into both embryonic and non-embryonic callus, and three immature embryo stages and the embryonic-specific activity of the promoter fragments was analyzed. We found that the activity of the regulatory sequence of AcSERK1 lacking −983 nt ~−880 nt, which included the transcription initiation site, was significantly reduced in the embryonic callus of pineapple, accompanied by the loss of embryonic cell-specific promoter activity. Thus, this fragment is an essential functional segment with highly specific promoter activity for embryonic cells, and it is active only from the early stages of somatic embryo development to the globular embryo stage. This study lays the foundation for identifying mechanisms that enhance the efficiency of somatic embryogenesis in pineapple and other plants.
Roles of Topoisomerases in Heterochromatin, Aging, and Diseases
Authors: Lee Seung Kyu , Wang Weidong
Published: November 2019

Heterochromatin is a transcriptionally repressive chromatin architecture that has a low abundance of genes but an enrichment of transposons. Defects in heterochromatin can cause the de-repression of genes and transposons, leading to deleterious physiological changes such as aging, cancer, and neurological disorders. While the roles of topoisomerases in many DNA-based processes have been investigated and reviewed, their roles in heterochromatin formation and function are only beginning to be understood. In this review, we discuss recent findings on how topoisomerases can promote heterochromatin organization and impact the transcription of genes and transposons. We will focus on two topoisomerases: Top2α, which catenates and decatenates double-stranded DNA, and Top3β, which can change the topology of not only DNA, but also RNA. Both enzymes are required for normal heterochromatin formation and function, as the inactivation of either protein by genetic mutations or chemical inhibitors can result in defective heterochromatin formation and the de-silencing of transposons. These defects may contribute to the shortened lifespan and neurological disorders observed in individuals carrying mutations of Top3β. We propose that topological stress may be generated in both DNA and RNA during heterochromatin formation and function, which depend on multiple topoisomerases to resolve.
Sociocultural Attitudes towards Appearance, Self-Esteem and Symptoms of Body-Dysmorphic Disorders among Young Adults
Authors: Ahmadpanah Mohammad , Arji Mona , Arji Jaleh , Haghighi Mohammad , Jahangard Leila , Sadeghi Bahmani Dena , Brand Serge
Published: November 2019

Background: Beauty and an attractive body shape are particularly important during early adulthood, as both are related to greater mating success, positive social feedback, and higher self-esteem. The media may further influence common features of beauty. We tested whether higher body-dysmorphic disorder (BDD) scores were associated with sociocultural attitudes towards appearance. Additionally, we expected that a link between higher BDD scores and higher perceived media pressure would be mediated by lower self-esteem (SE). Method: 350 young Iranian adults (mean age: 24.17 years; 76.9% females) took part in the study. Participants completed questionnaires covering sociodemographic data, sociocultural attitudes towards appearances, and SE, while experts rated participants for symptoms of body dysmorphic disorders. Results: Higher BDD scores were associated with higher scores for sociocultural attitudes towards appearance, while SE was not associated with BDD or sociocultural attitudes towards appearance. Higher scores for sociocultural attitudes towards appearance and media pressure predicted higher BDD scores, while SE had no influence. Conclusion: Among young Iranian adults, sociocultural attitudes towards appearances and BDD scores, as rated by experts’, were related, while SE was not. The shared variance between symptoms of BDD and sociocultural attitudes towards appearance was low, suggesting that other factors such as mating and career concerns together with social feedback might be more important in explaining symptoms of body dysmorphic disorders.
Match Performance of Soccer Teams in the Chinese Super League—Effects of Situational and Environmental Factors
Authors: Zhou Changjing , Hopkins William G. , Mao Wanli , Calvo Alberto L. , Liu Hongyou
Published: November 2019

To investigate the effects of situational factors (match location, strength of team and opponent) and environmental factors (relative air humidity, temperature and air quality index) on the technical and physical match performance of Chinese Soccer Super League teams (CSL). The generalized mixed modelling was employed to determine the effects by using the data of all 240 matches in the season 2015 collected by Amisco Pro®. Increase in the rank difference would increase the number of goal-scoring related, passing and organizing related actions to a small-to-moderate extent (Effect size [ES]: 0.37–0.99). Match location had small positive effects on goal-scoring related, passing and organizing related variables (ES: 0.27–0.51), while a small negative effect on yellow card (ES = −0.35). Increment in relative air humidity and air quality index would only bring trivial or small effects on all the technical performance (ES: −0.06–0.23). Increase in humidity would decrease the physical performance at a small magnitude (ES: −0.55–−0.38). Teams achieved the highest number in the physical performance-related parameters at the temperature between 11.6 and 15.1 °C. In the CSL, situational variables had major effects on the technical performance but trivial effects on the physical performance, on the contrary, environmental factors affected mainly the physical performance but had only trivial or small impact on the technical performance.
Effect of Topographic Data Accuracy on Watershed Management
Authors: Fathy Ismail , Abd-Elhamid Hany , Zelenakova Martina , Kaposztasova Daniela
Published: November 2019

A digital elevation model (DEM) is a digital model or 3D representation of a terrain’s surface. There are many methods to create DEM such as LiDAR, stereo photogrammetry and topographic maps. DEMs are very important for many applications such as extracting terrain parameters for geomorphology and modeling water flow for hydrology or mass movement. A number of websites are available to provide DEM such as SRTM, GTOPO30 and ASTER GDEM but their accuracy differs from one to another and also selecting a small DEM size (high resolution) gives accurate information, but the analysis takes long time. This paper aims to analyze the impact of using different available DEMs on watershed geomorphological properties on order to provide guidelines for users to select the most suitable DEM that obtain an accurate analysis in less time. Three programs; watershed modeling systems: WMS, Global Mapper and Google Earth were used in this study. Three case studies were studied to check the accuracy of these models and select the most accurate one for application. Satellite images downloaded from Google Earth were used as a guide reference for the comparison due to their accuracy and high resolution. The results indicated that the SRTM model was more accurate (95%) for all case studies according to our comparison between its delineation and satellite images. ASTER GDEM is the second most accurate model with an accuracy of 87%, the GTOPO30’s accuracy is 80%.
Assessment of Groundwater Quality and Human Health Risk (HHR) Evaluation of Nitrate in the Central-Western Guanzhong Basin, China
Authors: Zhang Qiying , Xu Panpan , Qian Hui
Published: November 2019

To investigate the quality of domestic groundwater and assess its risk to inhabitants of the Guanzhong Basin, China, 191 groundwater samples were collected to analyze major ions, nitrate, pH, total dissolved solids (TDS), total hardness (TH), and electrical conductivity (EC). The physiochemical parameters, hydrochemical facies, and sources of major ions were analyzed using Durov diagrams, bivariate diagrams, and chloro-alkaline indices (CAI-I and CAI-II). The suitability of groundwater for drinking, the nitrate distribution, and human health risk (HHR) for different age groups were evaluated. The results showed that the relative abundance of cations in the groundwater samples was K++Na+ > Ca2+ > Mg2+, while that of anions was HCO3− > SO42− > Cl− > NO3−. Groundwater samples mainly contained HCO3-Na and HCO3-Ca, which were introduced mainly by rock weathering and ion exchange. The groundwater in the Guanzhong Basin contained mainly good and medium water, and the groundwater in the southern part of the Wei River was better than that north of the Wei River. Areas containing high nitrate concentrations were mainly located in the central and western parts of the Guanzhong Basin. The percentages of low risk (<45 mg/L), high risk (45–100 mg/L), and very high risk (>100 mg/L) of nitrate pollution in the study area were 90.58%, 8.9%, and 0.52%, respectively. The HHR assessment results indicated that people in the 6–12 month age group were more likely to suffer from health complications due to a higher nitrate concentration, followed by 6–11 years, 21–65 years, 18–21 years, ≥65 years, 11–16 years, and 16–18 years age groups, which was mainly due to the different exposure parameters. The results of this study will be useful in regional groundwater management and protection.
‘Having a Quiet Word’: Yarning with Aboriginal Women in the Pilbara Region of Western Australia about Mental Health and Mental Health Screening during the Perinatal Period
Authors: Carlin Emma , Atkinson David , Marley Julia V
Published: November 2019

Despite high rates of perinatal depression and anxiety, little is known about how Aboriginal women in Australia experience these disorders and the acceptability of current clinical screening tools. In a 2014 study, the Kimberley Mum’s Mood Scale (KMMS) was validated as an acceptable perinatal depression and anxiety screening tool for Aboriginal women in the Kimberley region of Western Australia. In the current study, we explored if it was appropriate to trial and validate the KMMS with Aboriginal women in the Pilbara. Yarning as a methodology was used to guide interviews with 15 Aboriginal women in the Pilbara who had received maternal and child health care within the last three years. Data were analysed thematically, the results revealing that this cohort of participants shared similar experiences of stress and hardship during the perinatal period. Participants valued the KMMS for its narrative-based approach to screening that explored the individual’s risk and protective factors. While support for the KMMS was apparent, particular qualities of the administering health care professional were viewed as critical to the tool being well received and culturally safe. Building on these findings, we will work with our partner health services in the Pilbara to validate the KMMS with Pilbara Aboriginal women.