bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of a UPLC-ESI-MS/MS method for the determination of triamcinolone acetonide in human plasma and evaluation of its bioequivalence after a single intramuscular injection in healthy volunteers
Authors: Zhao Pengfei , Qi Ying
Published: July 2023

Introduction: Triamcinolone acetonide (TA) is commonly used in the treatment of various inflammatory conditions. To ensure its efficacy and safety, it is important to accurately determine its concentration in human plasma and evaluate its bioequivalence. In this study, an efficient ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS/MS) method was developed for the quantification of TA in human plasma after a single intramuscular injection. The internal standard used in this method was cortisone acetate (CA).

Methods: TA and CA were extracted from plasma using ethyl acetate and N-hexane (4:1, v/v), separated on a C18 reverse-phase column with a mobile phase of acetonitrile-water containing 1% formic acid (55:45, v/v), and analyzed by UPLC-ESI-MS/MS. Multiple-reaction monitoring was performed using the transitions m/z 435.4→397.3 for TA and m/z 403.4→163.1 for CA.

Results: The developed UPLC-ESI-MS/MS method demonstrated linearity over a concentration range of 0.53–21.20 ng/mL, with a lower limit of quantification of 0.53 ng/mL. The intra- and inter-run precision values ranged from 3.007% to 9.960% and 3.528% to 11.26%, respectively. The intra- and inter-run accuracy ranges were −1.962% to −6.577% and −3.371% to 0.348%, respectively. The matrix effect, extraction recovery, and stability of TA all met the acceptance criteria recommended by the National Medical Products Administration (NMPA) for bioassays. In healthy volunteers who received a single intramuscular injection of 80 mg of either the test or reference formulation of TA, various pharmacokinetic parameters were determined. Cmax was found to be 8.616 ± 1.232 and 8.285 ± 1.218 ng/mL for the test and reference formulations, respectively. Tmax was approximately 1.833 ± 0.243 and 1.861 ± 0.230 h. The t1/2 was calculated to be 181.249 ± 78.585 and 201.782 ± 83.551 h. AUC0-720 was 835.642 ± 297.209 and 830.684 ± 331.168 ng h/mL, AUC0-∞ was 991.859 ± 355.939 and 1018.665 ± 420.769 ng h/mL for the test and reference formulations, respectively. The average relative bioavailability of TA, determined using AUC0-720, was 105.4 ± 26.9%. Bioequivalence was evaluated through variance analysis and a double unilateral test, and the 90% confidence intervals of AUC0-720, Cmax, and AUC0-∞ were 92.8%–113.4%, 99.1%–109.1%, and 89.7%–110.9%, respectively (all p > 0.05).

Discussion: These results met the bioequivalence criteria set by the NMPA, indicating that the developed UPLC-ESI-MS/MS method accurately determined TA concentrations in the plasma of healthy Chinese volunteers and that the test and reference formulations exhibited bioequivalence in these individuals.
Numerical study of the effect of a magnetic field on Rayleigh-Taylor instability with different density disturbances
Authors: Sun Wei , Lv Chong , Feng Li , Wang Jianzhao , Wang Zhao , He Chuangye
Published: July 2023

Rayleigh-Taylor instability (RTI) is a fundamental physical process in fluids and plasmas. RTI is ubiquitous and must be considered in the field of high-energy-density physics, such as in space physics, astrophysics, and inertial confinement fusion. In this work, two-dimensional numerical simulations of laser-driven RTI with different density perturbations are performed using a radiation magnetohydrodynamic simulation program (FLASH). The effect of the applied magnetic field on the evolution of RTI at different Atwood numbers is systematically discussed. The results show that RTI evolves freely without an external magnetic field, and it is accompanied by the generation of secondary Kelvin–Helmholtz instability. Reducing the Atwood number weakens the mixing of fluids and has a strong stabilizing effect on the RTI. Introducing an external magnetic field parallel to the perturbation wave vector further inhibits the development of RTI and Kelvin–Helmholtz instability, with magnetic pressure playing a dominant role. The study results are important to gaining an in-depth understanding of the mixing of magnetic fluids and the magnetic field evolution at the instability interface and provide a reference for subsequent experimental studies on the related magnetization RTI.
Alpha Tocopherol-Induced Modulations in the Morphophysiological Attributes of Okra Under Saline Conditions
Authors: Naqve Maria , Wang Xiukang , Shahbaz Muhammad , Mahmood Athar , Bibi Safura , Fiaz Sajid
Published: July 2023

Foliar spray of antioxidants is a pragmatic approach to combat various effects of salinity stress in agricultural crops. A pot trial was conducted to examine the effect of exogenously applied α-tocopherol (α-Toc) as foliar spray to induce morpho-physiological modulations in two varieties (Noori and Sabzpari) of okra grown under salt stress conditions (0 mM and 100 mM NaCl). After 36 days of salinity treatments, four levels (0, 100, 200 and 300 mg L–1) of α-tocopherol were sprayed. Salt stress significantly reduced root and shoot fresh and dry biomass, photosynthesis rate (A), transpiration rate (E), water use efficiency (A/E), stomatal conductance, internal CO2 concentration (Ci)and Ci/Ca), and photosynthetic pigments. Foliar spray of α-tocopherol proved effective in improving the growth of okra by significantly enhancing root dry weight, root length, shoot fresh weight, shoot length, Chl. a, Chl. b, Total chl., β-Car., Total Car., A, E, A/E, Ci, and Ci/Ca, leaf and root Ca2+ and K+ ion content, total soluble sugars, non-reducing sugars and total soluble protein content by significantly reducing root Na+ ion content. The Okra variety Noori performed better than Sabzpari in the examined attributes, and 300 mg L–1 application of α-tocopherol was more pronounced in improving the growth of okra by alleviating salinity effects. Therefore, the use of α-tocopherol (300 mg L–1) as a foliar spray is recommended to improve okra production in saline soils.
Transcriptome and UPLC-MS/MS reveal mechanisms of amino acid biosynthesis in sweet orange ‘Newhall’ after different rootstocks grafting
Authors: Xiong Bo , Li Qin , Yao Junfei , Zheng Wei , Ou Yinghong , He Yuanyuan , Liao Ling , Wang Xun , Deng Honghong , Zhang Mingfei , Sun Guochao , He Siya , He Jiaxian , Zhang Xiaoai , Wang Zhihui
Published: July 2023

Sweet orange ‘Newhall’ (C. sinensis) is a popular fruit in high demand all over the world. Its peel and pulp are rich in a variety of nutrients and are widely used in catering, medicine, food and other industries. Grafting is commonly practiced in citrus production. Different rootstock types directly affect the fruit quality and nutritional flavor of citrus. However, the studies on citrus metabolites by grafting with different rootstocks are very limited, especially for amino acids (AAs). The preliminary test showed that there were significant differences in total amino acid content of two rootstocks (Poncirus trifoliata (CT) and C. junos Siebold ex Tanaka (CJ)) after grafting, and total amino acid content in the peel was higher than flesh. However, the molecular mechanism affecting amino acid differential accumulation remains unclear. Therefore, this study selected peel as the experimental material to reveal the amino acid components and differential accumulation mechanism of sweet orange ‘Newhall’ grafted with different rootstocks through combined transcriptome and metabolome analysis. Metabolome analysis identified 110 amino acids (AAs) and their derivatives in sweet orange ‘Newhall’ peels, with L-valine being the most abundant. L-asparagine was observed to be affected by both developmental periods and rootstock grafting. Weighted gene co-expression network analysis (WGCNA) combined with Redundancy Analysis (RDA) revealed eight hub structural genes and 41 transcription factors (TFs) that significantly influenced amino acid biosynthesis in sweet orange ‘Newhall’ peels. Our findings further highlight the significance of rootstock selection in enhancing the nutritional value of citrus fruits and might contribute to the development of functional citrus foods and nutritional amino acid supplements.
Creating the necessary infrastructure for a trauma-informed system of care for children and youth
Authors: Lyons John S. , Fernando April D.
Published: July 2023

Understanding and addressing the impact of adverse life events is an important priority in the design of helping systems. However, creating trauma-informed systems requires efforts to embed effective trauma-informed work in routine practice. This article discusses a model for developing trauma-informed systems using the Transformational Collaborative Outcomes Management (TCOM) framework, a strategy for engineering person-centered care. Person-centered care is naturally congruent with trauma-informed care. We describe the initial stages of implementation of a trauma-informed standardized assessment process to support the sustained evolution of trauma-informed care. Distinguishing between traumatic experiences and traumatic stress is fundamental to an effective trauma-informed system. We describe two sets of analyses—one in a statewide child welfare system and the other in a statewide behavioral health system. These projects found opportunities in the analysis of the detection of traumatic stress based on traumatic experiences to inform practice and policy. Being trauma-informed in child welfare is distinct from being trauma-informed in behavioral health. In child welfare, it appears that a number of children are resilient in the face of traumatic experiences and do not require trauma treatment interventions. However, delayed and missed traumatic stress responses are common. In behavioral health, misses often occur among adolescents, particularly boys, who engage in acting out behavior. Opportunities for the ongoing development of trauma-informed systems using the TCOM framework are discussed.
Video review of family medicine resident clinical encounters: a tool for building emotional intelligence
Authors: Koehler Aubry N. , Knudson Mark P. , Ballard Parissa J. , Nicolotti Linda M. , Caballero-Quinones Elimarie , Daniel Stephanie S.
Published: July 2023

Video Review (VR) is a well established educational tool for developing the practice of patient-centered care in family medicine residents. There are a number of behaviorally-based checklists that can be use in both live observation as well as VR of clinical encounters to identify and promote behaviors associated with patient-centered care, most of which also overlap with behaviors associated with Emotional Intelligence (EI). We propose a VR that is structured less on a seek-and-find of clinician behaviors and more as a self-reflective exercise of how the clinician presents in the room alongside how they were feeling during that encounter. We believe that this exercise promotes the first two skills of EI (self-awareness and self-management) and then provides a foundation on which to build the second pair of skills (social awareness and relationship management). This perspective paper offers guidance, including stepwise instruction, on how to facilitate such a VR curriculum.
Cost-effectiveness analysis of implementing polygenic risk score in a workplace cardiovascular disease prevention program
Authors: Mujwara Deo , Kintzle Jen , Di Domenico Paolo , Busby George B. , Bottà Giordano
Published: July 2023

Background

Polygenic risk score for coronary artery disease (CAD-PRS) improves precision in assessing the risk of cardiovascular diseases and is cost-effective in preventing cardiovascular diseases in a health system and may be cost-effective in other settings and prevention programs such as workplace cardiovascular prevention programs. Workplaces provide a conducitve environment for cardiovascular prevention interventions, but the cost-effectiveness of CAD-PRS in a workplace setting remains unknown. This study examined the cost-effectiveness of integrating CAD-PRS in a workplace cardiovascular disease prevention program compared to the standard cardiovascular workplace program without CAD-PRS and no-workplace prevention program.

Methods

We developed a cohort simulation model to project health benefits (quality-adjusted life years gained) and costs over a period of 5 years in a cohort of employees with a mean age of 50 years. The model health states reflected the risk of disease (coronary artery disease and ischemic stroke) and statin prevention therapy side effects (diabetes, hemorrhagic stroke, and myopathy). We considered medical and lost productivity costs. Data were obtained from the literature, and the analysis was performed from a self-insured employer perspective with future costs and quality-adjusted life years discounted at 3% annually. Uncertainty in model parameter inputs was assessed using deterministic and probabilistic sensitivity analyses. Three programs were compared: (1) a workplace cardiovascular program that integrated CAD-PRS with the pooled cohort equation—a standard of care for assessing the risk of cardiovascular diseases (CardioriskSCORE); (2) a workplace cardiovascular prevention program without CAD-PRS (Standard-WHP); and (3) no-workplace health program (No-WHP). The main outcomes were total costs (US $2019), incremental costs, incremental quality-adjusted life years, and incremental cost-effectiveness ratio.

Results

CardioriskSCORE lowered employer costs ($53 and $575) and improved employee quality-adjusted life years (0.001 and 0.005) per employee screened compared to Standard-WHP and No-WHP, respectively. The effectiveness of statin prevention therapy, employees' baseline cardiovascular risk, the proportion of employees that enrolled in the program, and statin adherence had the largest effect size on the incremental net monetary benefit. However, despite the variation in parameter input values, base case results remained robust.

Conclusion

Polygenic testing in a workplace cardiovascular prevention program improves employees' quality of life and simultaneously lowers health costs and productivity monetary loss for employers.
Health promoting sports federations: theoretical foundations and guidelines
Authors: Van Hoye Aurélie , Geidne Susanna , Vuillemin Anne , Dowd Kieran , Glibo Iva , Heck Sandra , Ibsen Bjarne , Johnson Stacey , Kingsland Melanie , Kokko Sami , Lane Aoife , Ooms Linda , Overbye Marie , Woods Catherine , Zeimers Geraldine , Whiting Stephen , Winand Mathieu
Published: July 2023

Background

Researchers and policy-makers have highlighted that the potential for organized sports to promote health has been underexploited. Sports clubs have limited capacity to promote health due to their voluntary nature and have called for support from their national sports federations. The present article provides guidelines, based on the theoretical principles of health promoting sports clubs and an analysis of practical tools and proven strategies, to support national sports federations to invest in health promotion (HP).

Methods

A qualitative iterative study was undertaken, based on five 2-h meetings of a group of 15 international researchers in HP in sports clubs. Notes and minutes from meetings, as well as shared outputs were analyzed based on the health promoting sports club framework.

Results

Guidelines developed for national sports federations to promote health includes a definition of a health promoting sports federation (HPSF), a description of how the settings-based approach to HP adapts to national sports federations, as well as practical applications of health promoting sports club’s intervention strategies. The analysis of existing tools also demonstrated that most tools are centered on a single dimension of health (social, mental, physical, spiritual or community), and often on a specific health topic. Furthermore, they do not cover HP as a continuous long-lasting process, but are generally short-term programs. The HPSF clarifies theoretical concepts, their practical implementation via case studies and outlines intervention components and tools useful for sports federations in their implementation of HP.

Conclusion

The guidelines developed in this study are intended to facilitate national sports federations to acknowledge/understand, reinforce/underpin and foster current and further investment in HP.
The effects of pharmaceutical interventions on potentially inappropriate medications in older patients: a systematic review and meta-analysis
Authors: Zhou Shuang , Li Rui , Zhang Xiaolin , Zong Yutong , Lei Lili , Tao Zhenhui , Sun Minxue , Liu Hua , Zhou Ying , Cui Yimin
Published: July 2023

Introduction

Potentially inappropriate medications (PIMs) is a particular concern in older patients and is associated with negative health outcomes. As various interventions have been developed to manage it, we performed a systematic review and meta-analysis to evaluate the effect of pharmaceutical interventions on outcomes of PIMs in older patients.

Methods

Meta-analysis of eligible randomized controlled trials (RCTs) was conducted to report the outcomes of pharmaceutical interventions in older patients searching from the databases of Cochrane Library, PubMed, Embase, Web of Science, Clinicaltrials.gov, SinoMed and Chinese Clinical Trial Registry (ChiCTR). The PRISMA guidelines were followed and the protocol was registered in PROSPERO (CRD42019134754). Cochrane bias risk assessment tool and the modified Jadad scale were used to assess the risk bias. RevMan software was used for data processing, analysis and graphical plotting.

Results

Sixty-five thousand, nine hundred seventy-one patients in 14 RCTs were included. Of the primary outcomes, pharmaceutical interventions could significantly reduce the incidence of PIMs in older patients (OR = 0.51, 95% CI: 0.42, 0.62; p < 0.001), and the number of PIMs per person (MD = -0.41, 95%CI: −0.51, −0.31; p < 0.001), accompanying by a low heterogeneity. Subgroup analysis showed that the application of computer-based clinical decision support for pharmacological interventions could remarkably decrease the incidence of PIMs and two assessment tools were more effective. Of the secondary outcomes, the meta-analysis showed that pharmacological interventions could reduce the number of drugs used per person (MD = -0.94, 95%CI: −1.51, −0.36; p = 0.001) and 30-day readmission rate (OR = 0.58, 95%CI: 0.36, 0.92; p = 0.02), accompanying by a low heterogeneity. However, the pharmaceutical interventions demonstrated no significant improvement on all-cause mortality and the number of falls.

Conclusion

Our findings supported the efficacy of pharmaceutical interventions to optimize the use and management of drugs in older patients.

Systematic review registration

https://clinicaltrials.gov/, CRD42019134754.
External assessment of medical education quality: indicative model development considering paradox of skill
Authors: Artyukhov Artem , Gavurova Beata , Volk Iurii , Bilan Svitlana , Lyeonov Serhiy , Mudarri Tawfik
Published: July 2023

This study proposes an approach to the external evaluation of medical education programs' quality based on a combination of indicators, including international rankings, external stakeholders' input, and independent agencies' assessments. We modify the success equation with a detailed consideration of the skill component and its decomposition into internal and external quality assurance elements along with authority. We carried out a bibliometric analysis regarding the problem of medical education quality assessment in the context of achieving sustainable development goals. We described the calculation model of external quality assessment indicators through the algorithms of independent education quality assurance agencies' activity and rating indicators shown in the modified Mauboussin's equation. The model considers the economic component (the consequence of achievement) of skill, which is expressed in raising funds from external sources to implement educational and scientific activities. The proposed algorithm for assessing the educational program quality can be applied to benchmark educational program components, complete educational programs within the subject area, and the educational institution for different areas. We propose a “financial” model for educational program quality based on the analysis results. The model makes it possible to determine the need for additional focused funding of the educational program based on the individual analysis of the external evaluation criteria of the achievement level. This study analyzes the accreditation results of more than 110 educational programs in 2020 and 8 months of 2021 within the direction 22 “Medicine” (according to the national classification of fields of knowledge) (state and private Ukrainian medical universities).
The relationship between dominant Western discourse and personal narratives of female genital cutting: exploring storytelling among Swedish-Somali girls and women
Authors: Palm Camilla , Elmerstig Eva , Holmström Charlotta , Essén Birgitta
Published: July 2023

Introduction

A dominant narrative, referred to as “the standard tale,” prevails in popular representations about female genital cutting (FGC) that often contrast with how cut women traditionally narrate their FGC experience as meaningful in contexts where FGC is customary. However, scholarship has increasingly highlighted how global eradication campaigns and migration to countries where FGC is stigmatized provide women with new frames of understanding which may lead to a reformulation of previous experiences. This article subjects the storytelling itself to analysis and explores how participants narrate and make sense of their FGC experience in a post-migration setting where FGC is stigmatized.

Methods

Semi-structured focus groups (9) and individual interviews (12) with Swedish-Somali girls and women (53) were conducted.

Results

The article highlights how the participants navigate their storying in relation to "the standard tale" of FGC in their efforts to make sense of their experiences. Navigation was conducted both at an intrapersonal level through continuous identity work, and in relation to the social context in interpersonal encounters, i.e., with service providers and others, among whom the standard tale has become a truth.

Discussion

The article places the analysis within broader discussions about anti-FGC work and considers the implications in relation to efforts to end FGC.
Detection and quantification of pesticide residues in tomatoes sold in urban markets of Ouagadougou, Burkina Faso
Authors: Dione Michel Mainack , Djouaka Rousseau , Mbokou Serge Foukmeniok , Ilboudo Guy Sidwatta , Ouedraogo Abdoul Aziz , Dinede Getachew , Roesel Kristina , Grace Delia , Knight-Jones Theodore J. D.
Published: July 2023

Introduction

“What people worry about, and what makes them sick and kills them, are not the same” is maxim for risk communication experts. In Burkina Faso, pesticides are used by vegetable producers to improve productivity. However, consumer concern over pesticide use is high. Of course, if over-used pesticides could have serious health consequences for producers and consumers and also cause ecological damage.

Methods

A cross-sectional survey was conducted to detect and quantify the levels of residues of pesticides in tomatoes sold in urban markets of Ouagadougou. Two samples were collected from each vendor (n = 328 vendors) making a total of 656 tomato samples from 26 markets. Samples were subjected to High-Performance Liquid Chromatography (HPLC) for detection and quantification of six pesticide residues commonly used in West Africa including acetamiprid, chlorpyrifos, lambda-cyhalothrin, deltamethrin, dichlorodiphenyltrichloroethane (DDT), and permethrin.

Results

Overall, 62.2% of tomato samples contained at least one pesticide residue including acetamiprid, chlorpyrifos, lambda-cyhalothrin and DDT. Deltamethrin and permethrin were however not detected in any samples. The highest proportions of samples were contaminated with DDT (32.9, 95%CI: 27.9–38.3%), followed by acetamiprid (31.1, 95%CI: 26.2–36.5%), lambda-cyhalothrin (28.4, 95%CI: 23.6–33.6%) and chlorpyrifos (10.7, 95%CI, 7.6–14.6%). 21.3% of samples exceeded Codex Alimentarius Commission (CAC) Maximum Residue Levels (MRLs) including Acetamiprid (13.1%), DDT (7.3%), lambda-cyhalothrin (2.1%) and chlorpyrifos (0.3%); while 61.3% of sample exceeded European Union (EU) MRLs. Multiple pesticide residues (up to 4) were detected simultaneously in 27.7% of the total samples.

Conclusion

The study suggests that producers and consumers may be exposed to pesticides that can be highly toxic to them and to the environment. We recommend further quantitative risk assessment for consumer exposure and identification of best procedures to reduce residues in vegetables. Meanwhile, monitoring and regulating pesticide use, with the promotion of good agricultural practices, are warranted to prevent consumers, producers and environmental exposure. However, given this may not be effective, promotion of consumer washing and peeling of vegetables may be warranted to at least empower consumers to protect themselves. Moreover, where resources are scarce they should be directed to the highest burden hazards and in Burkina Faso, these are not likely to be pesticides.
Study on the Optimal Design Method of the Containment Ring for an Air Turbine Starter
Authors: Zhang Yanan , He Zekan , Xuan Haijun , Liu Jianxin , Guo Xiaojun , Mi Dong , Fang Zehui
Published: July 2023

The airworthiness standards of transport category airplanes clearly stipulate that the equipment containing high-energy rotors must be shown by test that it can contain any failure of a high-energy rotor that occurs at the highest speed. The air turbine starter (ATS) is typical equipment containing high-energy rotors, and the manufacturers of ATS attach great importance to research on structural containment and weight reduction. In this paper, an optimal design method for a U-type containment ring is proposed. The method adopts the optimal Latin hypercube design, numerical simulation, response surface modeling, and genetic algorithm to achieve the multi-parameter optimal design of the containment ring section. By combining simulation and experiment, the influence weights of different structural parameters of the containment ring on the residual kinetic energy of debris and the containment ring volume were analyzed. The influence of different structural parameters of a U-type containment ring on containment results was studied, and a containment test was carried out to verify the containment capability of an optimized containment ring. The results show that the thickness of the containment ring has the greatest influence on the residual kinetic energy of the debris, and the weight ratio is 38%. The maximum radial deformation of the optimized containment ring can reach 22.3%, which means that the energy absorption effect of the containment ring on the disk fragments is significantly improved. With the same containment capability, the weight reduction effect of an optimized containment ring can reach 26.5%. The research results can provide weight reduction optimization methods and design theoretical guidance for U-type containment structures.
Survey of Semi-Empirical Jet Noise Models for Preliminary Aircraft Engine Design
Authors: Petrosino Francesco , Barbarino Mattia
Published: July 2023

Scientific research studies on jet noise generation have been ongoing since the early 1950s, when turbojets were first used in commercial aircraft. Several numerical methods have been developed with the aim of reducing the environmental issues related to the impact of jet noise on community annoyance. Among them, the development of fast and comprehensive tools for jet noise prediction captured the attention of researchers and engineers, being very useful in the preliminary design phase of aircraft engines. This work deals with an extensive survey of James R. Stone’s models, initially formulated for the National Aeronautics and Space Administration (NASA) by Modern Technologies Corporation (MTC), and their implementation in a contemporary numerical framework. The models and their implementation are validated by simulating different engine settings and nozzle configurations taken from the literature with the main scope of highlighting the strengths and weaknesses of the different semi-empirical formulations and setting guidelines for their effective use during the design phases of the next generation of supersonic aircraft.
A Rapid Surrogate Model for Estimating Aviation Noise Impact across Various Departure Profiles and Operating Conditions
Authors: Peng Howard , Bhanpato Jirat , Behere Ameya , Mavris Dimitri N.
Published: July 2023

Aviation noise remains a key barrier to the sustainable growth of commercial aviation. The advent of emerging technologies, such as urban air mobility, and the renewed interest in commercial supersonic transport aircraft, has only further raised concerns over the resultant community noise exposure. The foundation of any noise mitigation effort is the ability to accurately model noise metrics over a wide range of scenarios. Aviation noise is influenced by a wide variety of factors, including aircraft type, payload weight, thrust settings, airport elevation, ambient weather, and flight trajectory. Traditional noise modeling paradigms rely on physics-based and empirical calculations, which are computationally expensive. Attempts at speeding up the computations with alternate models could deliver on speed or accuracy, but not both. Recent research has indicated that model order reduction techniques hold promise for transforming and greatly reducing the number of quantities that need to be modeled. Paired with surrogate modeling techniques, a rapid and accurate noise model can be generated. The research presented in this manuscript expands on the model order reduction method and develops a rapid noise surrogate model, which can account for the piloting actions, the ambient temperature, and airport elevation. The presented results indicate that the method works well with minimal error for most modeling scenarios. The results also outline avenues for improvement, such as using a different class of surrogate models or modeling additional training cases. The model developed in this research has numerous applications for multi-query applications, such as parametric trade-off analyses and optimization studies. With the inclusion of airport and aircraft parameters, the model enables the development of frameworks that optimize piloting actions for noise mitigation on the ground.
The Herbicide Glyphosate and Its Formulations Impact Animal Behavior across Taxa
Authors: Talyn Becky , Muller Kelly , Mercado Cindy , Gonzalez Bryan , Bartels Katherine
Published: July 2023

Use of glyphosate and glyphosate-based herbicides is ubiquitous in US agriculture and widespread around the world. Despite marketing efforts to the contrary, numerous studies demonstrate glyphosate toxicity to non-target organisms including animals, primarily focusing on mortality, carcinogenicity, renal toxicity, reproductive, and neurological toxicity, and the biochemical mechanisms underlying these physiological outcomes. Glyphosate toxicity also impacts animal behavior, both in model systems and in agricultural and environmentally relevant contexts. In this review, we examine the effects of glyphosate and glyphosate-based herbicides on animal behaviors, particularly activity, foraging and feeding, anti-predator behavior, reproductive behaviors, learning and memory, and social behaviors. Glyphosate can be detected both in food and in the environment, and avoided through activity and feeding strategies. However, exposure also reduces activity, depresses foraging and feeding, increases susceptibility to predation, interferes with courtship, mating, fertility and maternal behaviors, decreases learning and memory capabilities, and disrupts social behaviors. Changes in animal behavior as a result of glyphosate toxicity are important because of their sometimes severe effects on individual fitness, as well as ecosystem health. Implications for human behavior are also considered.
Genome-Wide Identification, Expansion, Evolution, and Expression Analysis Reveals ABCB Genes Important for Secondary Cell Wall Development in Moso Bamboo (Phyllostachys edulis)
Authors: Que Feng , Zhu Yaqi , Liu Qingnan , Wei Qiang , Ramakrishnan Muthusamy
Published: July 2023

The ATP-binding cassette subfamily B (ABCB) is an important transporter family, and many members are well known for their auxin transport function. However, reports on the function of the ABCB genes during Moso bamboo development are few. In this study, we identified and characterized 37 PhABCB genes in Moso bamboo and classified them into five subgroups, Ⅰ–Ⅴ. We further observed gene family expansion and gene loss events during the evolution of the PhABCB gene family. It was found that the expansion of the PhABCB family was mainly attributed to the whole-genome duplication and DNA-transposed duplication models. Gene co-expression analysis and quantitative real-time PCR revealed that several PhABCB genes may be involved in the development of the secondary cell wall (SCW) during the rapid growth of Moso bamboo. Through examining their expression in different parts of the bamboo internode where the cell walls exhibited different developmental stages, the roles of eight candidate PhABCBs in the SCW development were further characterized. Of the eight PhABCB genes, PhABCB7, PhABCB11, PhABCB14, and PhABCB21 may be involved in the SCW biogenesis in Moso bamboo. This study provides the basis for discovering the potential role of PhABCB genes in Moso bamboo cell wall development; further studies are needed to elucidate how these PhABCBs function in SCW development by regulating the polar transport of auxin.
Hierarchical Model-Based Deep Reinforcement Learning for Single-Asset Trading
Authors: Millea Adrian
Published: July 2023

We present a hierarchical reinforcement learning (RL) architecture that employs various low-level agents to act in the trading environment, i.e., the market. The highest-level agent selects from among a group of specialized agents, and then the selected agent decides when to sell or buy a single asset for a period of time. This period can be variable according to a termination function. We hypothesized that, due to different market regimes, more than one single agent is needed when trying to learn from such heterogeneous data, and instead, multiple agents will perform better, with each one specializing in a subset of the data. We use k-meansclustering to partition the data and train each agent with a different cluster. Partitioning the input data also helps model-based RL (MBRL), where models can be heterogeneous. We also add two simple decision-making models to the set of low-level agents, diversifying the pool of available agents, and thus increasing overall behavioral flexibility. We perform multiple experiments showing the strengths of a hierarchical approach and test various prediction models at both levels. We also use a risk-based reward at the high level, which transforms the overall problem into a risk-return optimization. This type of reward shows a significant reduction in risk while minimally reducing profits. Overall, the hierarchical approach shows significant promise, especially when the pool of low-level agents is highly diverse. The usefulness of such a system is clear, especially for human-devised strategies, which could be incorporated in a sound manner into larger, powerful automatic systems.
Processing of Enriched Pear Slices with Blueberry Juice: Phenolics, Antioxidant, and Color Characteristics
Authors: Seraglio Siluana Katia Tischer , Hernández-Velásquez Belkis Sarahí , Osses-Millar Moira Elizabeth , Malverde-Muñoz Bárbara Yolanda , Guerra-Valle María Estuardo , Pavez-Guajardo Constanza , Moreno Jorge
Published: July 2023

This study evaluated the effectiveness of phenolic compound incorporation from blueberry juice into pear slices (PS) using a combination of ohmic heating (OH) and vacuum impregnation (VI), followed by air-drying (AD) or freeze-drying (FD). Our results showed that OH increased the content of bioactive compounds and antioxidant capacity of blueberry juice, with the optimal OH condition set at 50 °C for 20 min under an electric field of 13 V·cm−1. Furthermore, the combination of VI and OH was efficient in enriching PS with bioactive compounds from blueberry juice (such as cyanidin and epigallocatechin), with the optimal VI/OH condition set at 50 °C for 90 min under an electric field of 7.8 V·cm−1. Moreover, anthocyanin pigments from blueberry juice affected the color parameters of PS by increasing the a* parameter and decreasing the b* and L* parameters. However, both FD and AD (at 40, 50, and 60 °C) negatively affected (p ≤ 0.05) the phenolic content and antioxidant capacity. Notably, AD at 60 °C showed the highest levels of phenolic compounds and antioxidant potential for both impregnated and non-impregnated PS.
Experimental Evaluation of Extended Reality Technologies in the Development of Individualized Three-Dimensionally Printed Upper Limb Prostheses
Authors: Górski Filip , Łabudzki Remigiusz , Żukowska Magdalena , Sanfilippo Filippo , Ottestad Morten , Zelenay Martin , Băilă Diana-Irinel , Pacurar Razvan
Published: July 2023

This paper presents results from experimental studies that assess the utilization of virtual, augmented, and mixed reality (VR, AR, MR) at different stages of developing personalized 3D printed upper limb prostheses for adult patients. The prostheses are designed automatically using the AutoMedPrint system, leveraging 3D scans as described in various prior publications. Various stages of development of the prosthesis are made as applications of different extended reality technologies. An assembly instruction is implemented as an immersive VR application, a configurator is designed as AR application and a configurator and try-on application is prepared and deployed in MR. The applications are tested by an international group of experts during a scheduled experiment. The experts then participate to surveys and comparatively evaluate the potential of all the XR technologies. The paper presents the development of these applications, provides a detailed account of the experimental process, including the rankings of XR technologies for different applications throughout the lifecycle of a prosthetic device.
The Impact of Multicomponent Exercise Protocols Order on the Maximum Voluntary Contraction of Older Women
Authors: Monteiro António Miguel , Rodrigues Sandra , Matos Sérgio , Encarnação Samuel , Teixeira José Eduardo , Barbosa Tiago M. , Rodrigues Filipe , Forte Pedro
Published: July 2023

The aim of this study was to evaluate the impact of exercise order in multicomponent training (MCT) on the maximum voluntary contraction (MVC) of older women. A total of 91 older women, ranging in age from 60 to 85 years, were randomly assigned to either Group A or Group B. Group A performed a warm up followed by aerobic training and resistance training, whereas Group B followed a warm up followed by resistance training and aerobic training. A control group (CG) did not engage in any exercise interventions. Statistical analysis was conducted using one-way ANOVA for between-group comparisons, and ANOVA was used for repeated measures. The results revealed that Group A demonstrated significant increases in MVC for knee extensors (KEs) between M1 and M3 (p < 0.001) and between M2 and M3 (p < 0.001). Similarly, Group A exhibited significant increases in MVC for knee flexors (KFs) between M1 and M3 (p = 0.001) and between M2 and M3 (p < 0.001). Both Group A and Group B demonstrated significant increases in MVC for elbow flexors (EFs) between M1 and M3 (p < 0.001). Furthermore, Group B showed a significant increase in hand grip strength (HGS) between M1 and M3 (p < 0.001). Overall, the findings suggest that initiating MCT with aerobic training followed by resistance training is the most effective approach for improving muscle strength in older women.
Experimental Simulation of Thunderstorm Profiles in an Atmospheric Boundary Layer Wind Tunnel
Authors: Aldereguía Sánchez Camila , Tubino Federica , Bagnara Anna , Piccardo Giuseppe
Published: July 2023

Thunderstorms have different features in comparison with synoptic events, including a typical nose-shaped mean wind speed profile and non-stationary characteristics in time intervals from 10 min to 1 h. The simulation of thunderstorms in traditional wind tunnels requires suitable devices in order to replicate their peculiar characteristics. Disregarding the non-stationary characteristics of thunderstorm outflows, this paper aims to study the possibility of adopting a passive device such as a specially designed grid in order to reproduce the nose-shaped mean wind speed profile. A widely adopted model of the mean wind velocity profile from the literature is employed as a target profile for the verification of the experimental findings. The results obtained show a good agreement between the measured and target mean wind speed profiles and an acceptable turbulence intensity level compared with full-scale and experimental measurements. The proposed device offers a practical and cost-effective solution to simulate the main characteristics of a thunderstorm event in a traditional atmospheric boundary layer wind tunnel, which could be adopted to assess the significance of thunderstorm loading on civil engineering structures and define the requirement for ad hoc specialist studies.
Tactual Articulatory Feedback on Gestural Input
Authors: Bongers Bert , van der Veer G. C.
Published: July 2023

The role of the sense of touch in Human–Computer Interaction as a channel for feedback in manipulative processes is investigated through the research presented here. The paper discusses how information and feedback as generated by the computer can be presented haptically, and focusses on the feedback that supports the articulation of human gesture. A range of experiments are described that investigate the use of (redundant) tactual articulatory feedback. The results presented show that a significant improvement of effectiveness only occurs when the task is sufficiently difficult, while in some other cases the added feedback can actually lower the effectiveness. However, this work is not just about effectiveness and efficiency, it also explores how multimodal feedback can enhance the interaction and make it more pleasurable—indeed, the qualitative data from this research show a perceived positive effect for added tactual feedback in the overall experience. The discussion includes suggestions for further research, particularly investigating the effect in free moving gestures, multiple points of contact, and the use of more sophisticated actuators.
Challenges and Opportunities of Force Feedback in Music
Authors: Frisson Christian , Wanderley Marcelo M.
Published: July 2023

A growing body of work on musical haptics focuses on vibrotactile feedback, while musical applications of force feedback, though more than four decades old, are sparser. This paper reviews related work combining music and haptics, focusing on force feedback. We then discuss the limitations of these works and elicit the main challenges in current applications of force feedback and music (FF&M), which are as follows: modularity; replicability; affordability; and usability. We call for the following opportunities in future research works on FF&M: embedding audio and haptic software into hardware modules, networking multiple modules with distributed control, and authoring with audio-inspired and audio-coupled tools. We illustrate our review with recent efforts to develop an affordable, open-source and self-contained 1-Degree-of-Freedom (DoF) rotary force-feedback device for musical applications, i.e., the TorqueTuner, and to embed audio and haptic processing and authoring in module firmware, with ForceHost, and examine their advantages and drawbacks in light of the opportunities presented in the text.
Machine Learning and Bagging to Predict Midterm Electricity Consumption in Saudi Arabia
Authors: Musleh Dhiaa A. , Al Metrik Maissa A.
Published: July 2023

Electricity is widely regarded as the most adaptable form of energy and a major secondary energy source. However, electricity is not economically storable; therefore, the power system requires a continuous balance of electricity production and consumption to be stable. The accurate and reliable assessment of electrical energy consumption enables planning prospective power-producing systems to satisfy the expanding demand for electrical energy. Since Saudi Arabia is one of the top electricity consumers worldwide, this paper proposed an electricity consumption prediction model in Saudia Arabia. In this work, the authors obtained a never-before-seen dataset of Saudi Arabia’s electricity consumption for a span of ten years. The dataset was acquired solely by the authors from the Saudi Electrical Company (SEC), and it has further research potential that far exceeds this work. The research closely examined the performance of ensemble models and the K* model as novel models to predict the monthly electricity consumption for eighteen service offices from the Saudi Electrical Company dataset, providing experiments on a new electricity consumption dataset. The global blend parameters for the K* algorithm were tuned to achieve the best performance for predicting electricity consumption. The K* model achieved a high accuracy, and the results of the correlation coefficient (CC), mean absolute percentage error (MAPE), root mean squared percentage error (RMSPE), mean absolute error (MAE), and root mean squared error (RMSE) were 0.9373, 0.1569, 0.5636, 0.016, and 0.0488, respectively. The obtained results showed that the bagging ensemble model outperformed the standalone K* model. It used the original full dataset with K* as the base classifier, which produced a 0.9383 CC, 0.1511 MAPE, 0.5333 RMSPE, 0.0158 MAE, and 0.0484 RMSE. The outcomes of this work were compared with a previous study on the same dataset using an artificial neural network (ANN), and the comparison showed that the K* model used in this study performed better than the ANN model when compared with the standalone models and the bagging ensemble.
The Effect of Alpha-Lipoic Acid in the Treatment of Chronic Subjective Tinnitus through the Tinnitus Handicap Inventory Scores
Authors: Sacchetto Luca , Monzani Daniele , Apa Enrico , Lovato Andrea , Caragli Valeria , Gherpelli Chiara , Palma Silvia , Genovese Elisabetta , Nocini Riccardo
Published: July 2023

Background and Objectives: Tinnitus affects millions of adults. Many therapies, including complementary and alternative medicine and tinnitus retraining therapies, have been trialed, but an effective option, particularly for chronic subjective tinnitus (CTS), is still lacking. Materials and Methods: This study investigated the effects of alpha-lipoic acid (600 mg. per day for two months) on two groups of patients using a questionnaire. One group (A) was affected by tinnitus associated with likely cochlear dysfunction and metabolic syndrome, and the other (B) was composed of subjects with acoustic nerve lesions. All the patients were asked to complete the Italian version of the tinnitus handicap inventory (THI) to determine the overall degree of perceived annoyance at the beginning and end of therapy. Pure tone averages for speech frequencies and for high frequencies were computed, and psychoacoustic pitch and loudness matches were determined for each subject before and after treatment. Results: The pure tone audiometry, pitch, loudness, and THI scores of both groups were reported. In group A, statistically significant differences were observed for the “functional” and “emotional” subscales. The total score of THI and the loudness of tinnitus were also significantly reduced. No statistically significant differences were observed in group B. Conclusions: These findings suggest a possible contribution of the antioxidant effect to the organ of Corti in subjects with metabolic syndrome and CST.