bluuebunny/crossref_metadata_2025 huggingface dataset:
Design Analysis and Structural Prediction of Bus Driver Chair Support: A Study Case using HOQ and FEM
Authors: Cho Joung Hyung , Ridwan Ridwan , Kusuma Rama Panji , Triyono Joko , Muhayat Nurul , Fajri Aprianur , Laksono Fajar Budi
Published: March 2023

The bus driver's comfort is crucial. The location of the driver's seat, which is correlated with the seat support design, is one of the elements supporting his comfort. The bus business chosen as a representative is PT Selamet Trans Abadi, which has its headquarters in Pati City, Central Java. By considering the Safety Factor, House of Quality (HOQ), weight, shape, and seat support dimensions, this study intends to ascertain how the characteristics of the bus seat support form after receiving a load or force. Conducting a field visit to gather the necessary data is the initial step in this research. The following stage is to decide on the design criteria based on the collected data. Next, use Solidwork to model the design. Using the Finite Element Method (FEM), this program can investigate design characteristics. The loading simulation under consideration includes clutch engagement, bus brake application, and clutch engagement, whether the support is static or stationary. The validation with two supporting journals is then run as the following step to validate the findings. The constant chair support fulfills the typical value, according to the study's findings, whereas support 1 is the most fracture-prone. The outcomes of supports 2 and 3 demonstrate that the support strength is weak since it is subjected to an unequal load.
Analysis of changes in selected hematological parameters in blood from primiparous dairy cows during last trimester of pregnancy and first two months of lactation
Authors:   Department of Physiology, Cytobiology and Proteomics, West Pomeranian University of Technology Szczecin, Klemensa Janickiego 29, 71-270 Szczecin, Poland, Skrzypczak Wiesław , Kurpinska Anna ,   Department of Physiology, Cytobiology and Proteomics, West Pomeranian University of Technology Szczecin, Klemensa Janickiego 29, 71-270 Szczecin, Poland, Baziuk Marlena ,   Department of Physiology, Cytobiology and Proteomics, West Pomeranian University of Technology Szczecin, Klemensa Janickiego 29, 71-270 Szczecin, Poland
Published: March 2023

Dynamic changes in an organism of heifers at the end of pregnancy, and in primiparous cows in early lactation, may imply changes in morphological parameters. Their evaluation may contribute to a better understanding of changes, occurring in an organism of pregnant and lactating young cows. Hence, the aim of the study was to investigate, analyze and evaluate the changes in hematological parameters of peripheral blood (RBC, MCV, HGB, MCH, MCHC, WBC, PLT and HCT) in pregnant heifers/primiparous cows, of Polish Holstein-Friesian of Black-and-White variety, during the last trimester of pregnancy and in the first two months of lactation, with particular emphasis on transition period. Blood parameters were analyzed with the use of analyzer: scil Vet abc Plus+ (HORIBA Medical), on the following dates: 90, 30, 14 and 7 days before parturition and 7, 14, 30 and 60 days after parturition. Results of the study indicate that the most abrupt changes were observed for hematocrit, erythrocyte count, leukocytes, thrombocytes and hemoglobin concentration in blood. Parameters of red blood cells, at the end of pregnancy and first two months of lactation, didn’t exhibit any statistically significant changes. Noteworthy, is the convergence of trends in hematocrit and hemoglobin during analyzed period. High and stable hematocrit at the end of pregnancy was due to the stable erythrocyte count in this period. Decrease in RBCs after calving, and lower values during first two months of lactation, caused postpartum decrease in hematocrit and its stabilization at a lower level. These observations denote indirectly changes in blood volume, during analyzed period, what is supported by: tendencies observed for hemoglobin concentration, and stable MCV and MCHC. Obtained results suggest high efficiency of homeostatic mechanisms in pregnant and lactating heifers/primiparous cows. Our results may be useful for comparative studies both in physiology and health disturbances research in cows during the pre and post-partum period.
Hubungan antara Kepuasan Kerja dengan Perilaku Kewargaorganisasian (PKO) Guru di SMSK Negeri Kecamatan Pasar Minggu Kota Administrasi Jakarta Selatan
Authors: Nugroho Dwi Sakti , Sutjipto Sutjipto , Matin Matin
Published: March 2023

This study aims to know there is a relationship between job satisfaction with teacher OCB at Vocational High School Pasar Minggu, South Jakarta Administration. This research use quantitative with two variables there in, namely: (X) job satisfaction as independent variables and (Y) OCB as the dependent variable. The method used is survey method with the results of the analysis of correlational studies. The population in this study are teacherâ€™s at vocational high school in Pasar Minggu, South Jakarta there is 275 teachers. Samples were taken by using simple random sampling technique. The technique is based on the sample size used in this study as many as 73 teachers. Data collection for the variable (X) job satisfaction and variable (Y) OCB using a questionnaire. Hypothesis testing is done using product moment correlation formula in can correlation coefficient (r) = 0,45283 and based on the results of hypothesis testing using t-test obtained t for 4.280 > 1.994 t-table. From this research, we get thereâ€™s positive relation between job satisfaction with OCB at Vocational High School Pasar Minggu, South Jakarta Administration. The contributions made by teachers job satisfaction on OCB, amounted to 20.51%.
Implementasi Praktik Kerja Lapangan Di Masa Pandemi Covid-19 Terhadap Kesiapan Kerja Mahasiswa Prodi Manajemen Pendidikan Universitas Negeri Jakarta
Authors: Rahmawati Desi - , Karenina Zahra , Farida Anita , Komala  , Rohma Wahdiniyah Nur
Published: March 2023

Dalam memberikan kesempatan mengaplikasikan teori dan praktik di lapangan, mahasiswa universitas negeri jakarta (UNJ) diwajibkan menjalani program Praktik Kerja Lapangan (PKL) yang disesuaikan dengan kebutuhan program studi masing-masing. Kegiatan PKL mahasiswa UNJ yang semula dilaksanakan secara tatap muka langsung di Industri tempat pelaksanaan, kini dilaksanakan secara online hal ini sesuai dengan kebijakan yang telah ditetapkan pemerintah dan universitas sejalan dengan kewaspadaan terhadap virus covid-19  (UNJ, 2020). Oleh karena itu, penelitian ini bertujuan untuk mengetahui implementasi praktik kerja lapangan (PKL) di masa pandemi covid-19 terhadap kesiapan kerja mahasiswa prodi manajemen pendidikan angkatan 2017 universitas negeri jakarta. Penelitian ini menggunakan metode kualitatif deskriptif. Sampel dalam penelitian ini adalah Mahasiswa Manajemen Pendidikan Universitas Negeri Jakarta Angkatan 2017 sebagai mahasiswa yang melaksanakan PKL di masa pandemi dan dosen koordinator PKL MP UNJ 2020. Teknik pengumpulan data yang peneliti gunakan adalah teknik wawancara, observasi dan dokumentasi. Hasil penelitian menunjukan  implementasi praktik kerja lapangan (PKL) di masa pandemi covid-19 mahasiswa manajemen Pendidikan UNJ dilaksanakan secara work from home (WFH) dan juga work from office (WFO) yakni menyesuaikan kebijakan instansi terkait. Dalam pelaksanaannya ditemukan beberapa hambatan dalam pelaksanaan PKL secara blended ini.
Evaluasi Program Bahasa Inggris Bertujuan Khusus dengan Pendekatan CIPP
Authors: Halim Nurhasanah
Published: March 2023

Bahasa Inggris untuk Tujuan Khusus (BIK) adalah pengajaran bahasa Inggris yang secara khusus bertujuan untuk memenuhi kebutuhan peserta didik dalam suatu program pembelajaran bahasa Inggris agar dapat berkomunikasi dalam konteks tertentu. Studi kualitatif ini berupaya untuk menjawab pertanyaan penelitian “Sejauhmana program Bahasa Inggris untuk tujuan Khusus bagi Sekretaris dan Tenaga Administrasi tersebut telah berhasil memenuhi kebutuhan perkembangan kemampuan bahasa Inggris dan kebutuhan belajar bahasa Inggris peserta didik?” dengan memanfaatkan komponen CIPP dalam pendekatan model evaluasi yang digagas oleh Stufflebeam. Komponen CIPP digunakan sebagai panduan perencanaan, pelaksanaan dan penilaian program ESP melalui kriteria berbasis teori yang diturunkan dari pemahaman peneliti tentang program pembelajaran bahasa (Kiely dan Rea-Dickins, 2005). Pengumpulan data dilakukan terhadap tigapuluh peserta, dua staf pengajar dan satu pengembang program melalui teknik wawancara. Hasil evaluasi menunjukkan bahwa program BIK telah berhasil memenuhi kebutuhan perkembangan keterampilan bahasa dan kebutuhan belajar bahasa Inggris peserta didik. Tantangan terbesar dalam pelaksanaan program BIK adalah mengurangi kecanggungan peserta dalam belajar bahasa Inggris tanpa memasukkan unsur struktur bahasa secara eksplisit. Selain itu, evaluasi ini juga menghasilkan panduan sistematis yang bisa digunakan untuk mengevaluasi program Bahasa Inggris untuk Tujuan Khusus pada penyedia program lain atau dapat juga digunakan pada evaluasi program pengajaran bidang studi lainnya.
Arah dan Perubahan Kebijakan Seleksi Mandiri Calon Mahasiswa Program Sarjana
Authors: Khalilah Khalilah
Published: March 2023

Changes in the student admission through an independent selection path have been conducted by Indonesian government/Ministry of education, culture, research and technology. Recently, the undergraduate student admission through an independent selection path was amended when Rector of State University of Lampung (UNILA) was detained by Indonesian Corupsion Commission through catch hands operation or OTT. A specific research focusing on such changes has been under-developed however. This article is specified to discuss this issue. Regulation documents related with this issue published by this government/ministry were exctracted using thematic qualitative content analysis. The findings are as follows. Changes in the undergraduate student admission policy have been formulated by this government/ministry since Law No.12/2012 was enacted up to 2022s. Commercial oriented undergraduate student admissions was explicitly prohibited by this law. However, regulations constituted by this government/ministry in between 2015s and 2020s did not restrain this issue straightforwardly. As such OTT incident took place, this ministry decreed a regulation, named as Permenristikdikti No.48/2022. Commercial-oriented undergraduate student admission using independent selection path was strictly prohibited by this regulation. This principle does not constrain Indonesian state universities’ authonomy regarding the undergraduate student admision. It instead, helps them to not being trapped in corruptive circle behaviors.
Pengaruh Kecerdasan Interpersonal Kepala Sekolah Terhadap Produktivitas Sekolah Dasar
Authors: Syafrudin  , Sudadio  , Hidayat Sholeh
Published: March 2023

Penelitian ini bertujuan untuk menganalisis dan mendeskripsikan pengaruh kompetensi kepemimpinan kecerdasan interpersonal kepala sekolah terhadap produktivitas Sekolah Dasar (SD) di Kota Serang. Penelitian ini dilaksanakan di Sekolah Dasar, Kota Serang, Provinsi Banten yang tersebar di enam kecamatan, yaitu Kecamatan Cipocok Jaya, Kecamatan Curug, Kecamatan Kasemen, Kecamatan Taktakan, Kecamatan Walantaka, dan Kecamatan Serang. Penelitian ini merupakan penelitian dengan pendekatan kuantitatif yang menggunakan metode penelitian survei jenis expost facto. Metode penelitian ini dipilih dengan mempertimbangkan permasalahan dan tujuan penelitian ini yaitu untuk menganalisis pengaruh kompetensi manajerial kepala sekolah terhadap produktivitas Sekolah Dasar (SD) di Kota Serang. Selain itu, data penelitian ini dikumpulkan tidak harus melalui treatment yang sengaja dilakukan oleh peneliti melainkan data yang dikumpulkan telah tersedia di lapangan dan dimiliki oleh responden sehingga hanya membutuhkan instrumen dalam bentuk angket untuk mengumpulkan data-data tersebut. Setelah dilakukan penelitian didapatkan bahwa Tidak terdapat pengaruh langsung positif kecerdasan interpersonal terhadap produktivitas sekolah pada lingkup Sekolah Dasar (SD) di Kota Serang, Provinsi Banten. Hal ini menjelaskan bahwa kecerdasan interpersonal yang semakin memadai belum mampu memberikan dampak yang positif terhadap meningkatnya produktivitas sekolah pada lingkup Sekolah Dasar (SD) di Kota Serang, Provinsi Banten.
Integrasi Model Dilemma-STEAM (Science, Technology, Engineering, Art, and Mathematics) Untuk Mengembangkan Kemampuan Kolaboratif dan Berpikir Kritis Siswa Sekolah Dasar
Authors: Erinna Talitha , Devi Yolanda , Murnilasari Indri , Tsabitah Nisrina , Rahmawati Yuli
Published: March 2023

Penelitian ini bertujuan untuk menganalisis kemampuan kolaboratif dan berpikir kritis siswa sekolah dasar dengan menerapkan inovasi model pembelajaran dilemma-STEAM yang merupakan integrasi dari dilemma stories dan STEAM PjBL (Science, Technology, Engineering, Art and Mathematics Project Based Learning) pada pembelajaran IPA kelas VI di salah satu sekolah dasar di Bekasi. Metode yang digunakan dalam penelitian ini adalah metode kualitatif dengan teknik pengumpulan data observasi dan wawancara. Analisis data melalui reduksi data, penyajian data, dan penarikan kesimpulan. Penelitian ini melibatkan tiga guru dan 80 siswa kelas VI. Aspek kemampuan kolaboratif meliputi kerja sama dan tanggung jawab dalam mengerjakan proyek yang diberikan. Sedangkan aspek kemampuan berpikir kritis meliputi interpretation, analysis, evaluation, dan inference dalam mengkonstruksi pengetahuannya untuk menyelesaikan proyek yang diberikan. Pada akhirnya model ini diharapkan dapat diterapkan untuk menciptakan pembelajaran yang bermakna dan mengembangkan kompetensi siswa.
Improved uncertainty evaluation for a long distance measurement by means of a temperature sensor network
Authors: Kok Gertjan , Gugole Federica , Seymour Aaron , Koops Richard
Published: March 2023

The aim of the research described in this paper was to more accurately determine the measurement uncertainty of an interferometric long distance measurement. The chosen method was to install a temperature sensor network in the laboratory to measure in more detail the ambient temperature profile to more accurately determine the local values of the refractive index on the path travelled by the laser light. The experimental measurements were supplemented by a theoretical analysis of the mathematical model being used. The outcome of the performed work was that the claimed measurement uncertainty of the distance measurement, which is based on using only 5 temperature sensors, was justified. However, if in the future a lower uncertainty would be needed, a sensor network like the one that was temporarily installed would be needed. During the measurement campaign an offset in the mean temperature of 0.2 °C was found, which was equal to the maximum allowed bias in view of the claimed uncertainty for the long distance measurement. At a more general level, it was concluded that such sensor networks provide a useful new tool to increase the understanding of other measurements, to validate assumptions and optimize existing measurements.
Efektivitas Model Pembelajaran Contextual Teaching and Learning (CTL) Berbasis STEM terhadap Kemampuan Berpikir Logis Siswa pada Pembelajaran IPA
Authors: Annisa Ariana Amalia , Fatmahanik Ulum
Published: March 2023

Pembelajaran IPA adalah pembelajaran yang menghubungkan materi dengan kehidupan sehari-hari sehingga kemampuan berpikir logis sangat diperlukan sebagai tolak ukur keberhasilan dalam pembelajaran. Peralihan sistem pembelajaran daring menuju luring menyebabkan kemampuan berpikir logis siswa dalam pembelajaran IPA cenderung rendah. Sehingga upaya yang dilakukan untuk memperbaiki pembelajaran adalah dengan menerapkan model pembelajaran CTL berbasis STEM, karena model ini dapat membantu siswa dalam memahami materi dengan menghubungkan pada kehidupan sehari-hari serta meningkatkan aktivitas siswa. Tujuan penelitian ini untuk mengetahui bagaimana keterlaksanaan pembelajaran dan aktivitas siswa, mengetahui efektivitas model pembelajaran CTL berbasis STEM terhadap kemampuan berpikir logis siswa. Metode penelitian menggunakan penelitian kuantitatif, jenis penelitian quasi eksperimen dengan non equivalent control group design. Instrumen penelitian menggunakan lembar keterlaksanaan dan aktivitas siswa serta soal tes kemampuan berpikir logis. Analisis penelitian menggunakan uji-t dan N-Gain. Hasil penelitian menunjukkan keterlaksanaan pembelajaran dan aktivitas siswa berjalan lancar dengan kategori baik. Kemudian pada hasil uji-t dapat disimpulkan H0 ditolak dan H1 diterima artinya terdapat perbedaan kemampuan berpikir logis siswa pada kelas eksperimen dan kontrol. Berdasarkan uji N-Gain menghasilkan rata-rata kelas eksperimen lebih tinggi dibanding kelas kontrol yaitu sebesar 57,2496. Sehingga model pembelajaran Contextual Teaching and Learning (CTL) berbasis STEM berpengaruh dan cukup efektif dalam meningkatkan kemampuan berpikir logis siswa
Analysis of the factors influencing the preoperative blood pressure fluctuation in patients undergoing elective surgery
Authors: Cheng Zifei , Ying Yaoyu , Peng Li , Zhang Lihui , Qin Haipeng , Huang Xiansong , Liu Xiwen , Liang Dali , Xie Hong
Published: March 2023

Background and Aims: To analyze the factors affecting preoperative blood pressure fluctuations in patients undergoing elective surgical surgery.
Methods and Results: In 776 elective surgical patients from January to October 2021, the changes of BP and base BP (1 day before the operation) were analyzed by more than 20%, divided into elevated BP group (n=328) and non-fluctuating group (n=448), and analyzed by multivariate logistic regression. Results 776 patients were included, including 335 men and 441 women; SBP increased 12.98±19.33mmHg 1 day before surgery and DBP increased 6.67±13.20mmHg 1 day before surgery. There were 328 patients with more than 20% fluctuation range, and the incidence of preoperative blood pressure increase reached 42.27%. After a multivariate logistic regression analysis, age, preoperative association with hypertension, and sleep duration at 1 day before surgery were independent risk factors for preoperative BP fluctuations. Older blood pressure is more likely to fluctuate (OR=1.021,95%CI: 1.007-1.035, P =0.0030); 1.785 times more frequently (OR=1.785,95%CI: 1.142 ~ 1.807, P =0.0114) before 1 day (OR=0.835,95%CI: 0.747~0.932, P =0.0014) by stepwise regression.
Conclusion: The blood pressure in the operating room increased significantly from 1 day before surgery. Age, preoperative association with hypertension, and sleep duration of 1 day before surgery were independent risk factors affecting preoperative blood pressure fluctuations. And the older the age, the greater the fluctuation of blood pressure; the shorter the sleep time, the greater the difference of blood pressure.
Prevalence and associated factors of foot deformity among adult diabetic patients on follow-up at Debre Markos Comprehensive Specialized Hospital, Northwest Ethiopia, 2022
Authors: Adebabay Aderajew , Worede Amanuel , Sume Bickes , Mihiret Getachew , Shimelash Rahel , Goshu Bahiru
Published: March 2023

Introduction: Diabetes foot deformity is among the major causes of diabetic foot ulceration that results in lower limb amputation. But, the study on the distribution of foot deformity and its risk factors among diabetic patients in Ethiopia is not satisfactory; particularly there is no study in the study area.Objective: To assess the prevalence and associated factors of foot deformity among adult diabetic patients on follow-up at Debre Markos Comprehensive Specialized Hospital, Northwest Ethiopia, 2022Methods:A hospital-based cross-sectional study was conducted among 392 diabetic patients at Debre Markos Comprehensive Specialized Hospital from June 1st to July 30th, 2022, using a systematic random sampling technique. Data were collected by using pre-tested semi-structured questionnaires and diabetic foot assessment format, entered through epidata 4.6 versions, and exported to STATA 14 version for analysis. Multivariable binary logistic regression was used to determine the association between dependent and independent variables. Adjusted odds ratios (AOR) with their 95% Confidence interval (CL) were used to determine the strength of the association, and a variable with a p-value <0.05 were statistically significant in multivariable logistic regression.Result:The overall prevalence of foot deformity was 33.42% [95% CI: 28.9–38.3]. In the final multivariable binary logistic regression analysis, rural residency [AOR = 2.55, 95% CI: 1.26, 5.14], poor glycemic control [AOR = 2.63; 95% CI: 1.45, 4.79], diabetes duration between 11 and 15 years [AOR = 2.42; 95% CI: 1.12, 5.26], diabetes duration greater than 15 years [AOR = 4.62; 95% CI: 1.80, 11.82], inadequate footwear[AOR = 2.06; 95% CI: 1.13, 3.75] and presence of peripheral neuropathy [AOR = 8.11; 95% CI: 4.45, 14.77] were statistically significant associated factors with diabetes foot deformity.Conclusion:Theprevalence of foot deformity among adult diabetic patients was high. It is recommended to incorporate foot deformity screening in routine diabetic foot management.
Development of a hydrogel-based three Dimensional (3D) Glioblastoma Cell lines Culture as a Model System for CD73 inhibitor response study
Authors: Bahraminasab Marjan , Asgharzade Samira , Doostmohamadi Ali , Satari Atefeh , Hasannejad Farkhonde , Arab Samaneh
Published: March 2023

Despite the development of various therapeutic approaches over the past decades, the glioblastoma (GBM) treatment remains a major challenge. The extracellular adenosine-generating enzyme CD73 is involved in the pathogenesis and progression of GBM, and targeting CD73 may represent a novel approach to this cancer. This study characterized three-dimensional culture systems based on three compositions of hydrogel and chose an optimum type for local delivery of CD73 to target GBM cells as a possible therapeutic approach for this disease. Rheology measurements, Fourier Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), and cell proliferation assay were conducted to analyze the synthesized hydrogel and choose an optimal formula. The viability of tumor cells in the optimal hydrogel was assessed by histology and confocal microscopy imaging. Furthermore, tumor cells' sensitivity to CD73 inhibitor was investigated by cell proliferation assay and real-time PCR. The data demonstrated that the hydrogel with 5 w% gelatin and 5 w% sodium alginate had superior rheological properties and cell viability. Therefore, it could provide a more suitable environment for GBM cells and mimic the natural microenvironment more properly. CD73 inhibitor-treated GBM cells significantly decreased proliferation rate and expressions of VEGF and HIF1-α within the optimal hydrogel. Our current research revealed the great potential of CD73 inhibitor for clinical translation of cancer study by analyzing 3D tumor cell behavior and function, and therefore for more effective treatment protocols for GBM.
Disentangling the effects of supplementary feeding on population abundance and the aggregation of wild ungulates as drivers of the prevalence of tuberculosis in south-central Spain
Authors: Laguna Eduardo , Carpio Antonio , Ortega Zaida , Delgado Encarnación , Vicente Joaquín , Acevedo Pelayo
Published: March 2023

The supplementary feeding of wild ungulates is a common and pervasive practice throughout Europe, but the understanding on its unintended ecological effects is still limited. This management action has different degrees of intensity from artificial grasslands to supplementation in feeders, since the type and criteria of each supplementary feeding programme depend on managers’ objectives (e.g. maintaining harvesting yields, increasing animal body condition, mitigate agriculture or forest damage). The decision on how, when and where feed may determine the magnitude of the effects. Here, based on a long-term and well‐replicated dataset and using mixed structural equation model (mixed-SEM), we investigated the effects of supplementary feeding on red deer and wild boar abundance and aggregation and how directly and indirectly it affects the prevalence of tuberculosis-like lesions (TBL). We, therefore, hypothesized that supplying food avoiding the use of feeders would have less effect as regards increasing transmission rates, despite the fact that its efficiency as regards modulating population dynamics may be similar to the provision at feeders. Supplementary feeding was characterised in field surveys carried out on 60 hunting estates (south-central Spain) over four seasons (2002/2003, 2006/2007, 2012/2013 and 2018/2019). The abundance, aggregation and prevalence of TBL in red deer and wild boar were also determined. Collectively, our results showed that most of the variability in population aggregation could be directly explained by the population abundance and, to a lesser extent, by the degree of supplementation. Regarding red deer, there was a positive interaction between population abundance and aggregation in relation to the prevalence of TBL, suggesting that the positive effect of abundance on the prevalence of TBL is intensified by population aggregation. The model also showed a significant and positive correlation between the prevalence of TBL in both species. Finally, we reported a negative relationship between the degree of supplementary feeding and the prevalence of TBL in wild boar. Our findings shed light on the drivers of TBL prevalence in wild ungulate populations. Our results are relevant for the design of disease-control actions aimed at reducing the prevalence of tuberculosis and other shared diseases favoured by intensive wildlife management.
The Indicative Effects of Apolipoproteins on organic Erectile Dysfunction Diagnosed by the Nocturnal Penile Tumescence and Rigidity Test
Authors: Zhang Zhexin , Li Yuezheng , Pan Yang , Wang Shangren , Xu Mingming , Zhou Hang , Liu Xiao-Qiang
Published: March 2023

Background Erectile dysfunction (ED) is closely associated with cardiovascular diseases (CVD). Apolipoprotein (Apo) B, Apo A1, and Apo A1/Apo B are predictive indicators of CVD. A strong association among these proteins, ED and CVD has been partially demonstrated. However, Previous studies have confirmed the correlation between apolipoproteins and ED, but does not confirm that apolipoproteins are associated with organic ED but not with psychogenic ED. The results of the The nocturnal penile tumescence and rigidity (NPTR) test and the scale allowed the diagnosis of organic or psychogenic ED, and we more accurately confirmed the association between Apo B, Apo A1, Apo A1/Apo B and organic ED. Results In our study, patients with organic ED had considerably lower levels of Apo A1 and Apo A1/Apo B (P = .013 andP < .001, respectively), whereas patients with organic ED had considerably higher levels of Apo B (P = .024). With an AUC of 0.612 (95% CI: 0.537–0.688, cut-off < 0.95) and 0.655 (95% CI: 0.581–0.728, cut-off < 1.263), respectively, Apo A1 and Apo A1/Apo B exhibited a medium diagnostic value for the risk of organic ED, according to the ROC curve; however, Apo B had no sufficient diagnostic value. Conclusion According to our findings, through the NPTR test, Apo B, Apo A1, and Apo A1/Apo B were all risk factors for organic ED and CVD, but not for psychogenic ED. Additionally, it demonstrated that the proteins Apo A1 and Apo A1/Apo B are crucial in the genesis of organic ED and can be utilized as indicators to evaluate the risks of organic ED.
Heating and Cooling Load Estimation of Teacher Residential Block in Ghazni Technical University by CLTD/CLF Method and its Comparison with HAP Software
Authors: serat zainullah
Published: March 2023

The CLTD/CLF method and the HAP software for estimating the heating and cooling load for a teacher residential block at Ghazni Technical University. The study's objectives were to evaluate each method's strengths and drawbacks as well as its accuracy and dependability. The CLTD/CLF method was used to determine the heating and cooling loads, which came out to be 14.88 KW and 20.43 KW, respectively. Using the HAP program, these values are 14.4 KW and 20.4 KW, respectively. According to the study's findings, there are only modest differences between the two approaches' estimates of the heating and cooling loads. The HAP method was shown to be simpler and quicker than the CLTD/CLF method.
Development and Psychometric Validation of the Women-Sexually Objectifying Media Exposure Scale (W-SOMES) and Men-Sexually Objectifying Media Exposure Scale (M-SOMES)
Authors: Hu Zhuozhuo , Wood Chantelle , Buckland Nicola
Published: March 2023

In this digital era, individuals are regularly exposed to sexual objectification in a variety of media types, which may negatively affect body image. However, existing measures do not fully capture exposure to and direct experiences of sexual objectification in different media. The purpose of the current programme of research was to develop and evaluate the Women-Sexually Objectifying Media Exposure Scale (W-SOMES) and Men-Sexually Objectifying Media Exposure Scale (M-SOMES), to measure exposure to and experiences of sexual objectification in the media. In Study 1, drawing from existing literature and two online surveys (women = 80, men = 76, age representative samples), items for the W-SOMES and M-SOMES were developed. Optimal items solely reflected exposure to sexual objectification in the media. In Study 2, exploratory factor analysis (women = 340, men = 100) suggested an underlying structure of three correlated factors for the W-SOMES and a single factor for the M-SOMES. In Study 3, confirmatory factor analysis (women = 331, men = 328) supported a higher-order model for the W-SOMES (15 items across three subscales: Importance of Physical Appearance, Sexualised Body Representation and Body Evaluation) and a single factor model for the M-SOMES (4 items measuring Sexualised Body Representation). The W-SOMES and M-SOMES displayed satisfactory internal consistency, test-retest reliability, and differentiation by known groups but did not adequately display convergent and discriminant validity. The M-SOMES also displayed satisfactory incremental validity. Future research should further examine the psychometric properties of the W-SOMES and M-SOMES for measuring exposure to sexual-objectification in the media.
What is the Optimal Number of Embryos to Transfer for Poseidon Group 1 and Group 2? A retrospective study
Authors: Liu Rang , Zhang Qiuju , Geng Lan , He Huiqing , Xu Chang , Feng Jiali , Song Miaoling , Cao Yanpei , Wang Tianren , Xia Xi
Published: March 2023

Background: The 2016 Patient-Oriented Strategy Encompassing IndividualizeD Oocyte Number (POSEIDON) criteria redefined the poor responders as low prognosis patients. The embryo transfer strategy for Poseidon patients remained to be addressed. This study aimed to investigate the optimized number of embryos to transfer for unexpected low-prognosis patients (Poseidon Group 1 and Group 2) with blastocyst transfer in their first frozen cycle.
Methods: A retrospective cohort study of 2970 patients who underwent frozen-thawed embryo transfer (FET) between January 2018 and December 2021. Patients from Poseidon Group 1 (N=219) and Group 2 (N=135) who underwent blastocyst transfer in their first FET cycles were included and divided into the elective single embryo transfer (eSET) group and the double embryo transfer (DET) group.
Results: For Poseidon Group 1, the live birth rateper embryo transfer of the DET group was slightly higher than the eSET group (52.17% vs 46.15%, OR 0.786, 95% CI 0.462-1.337, P = 0.374; adjusted OR (aOR) 0.622, 95% CI 0.340-1.140, P = 0.124), while a significant increase of 20.00% in the multiple birth rate was shown. For Group 2, higher live birth rates were observed in the DET group compared to the eSET group (38.46% vs 20.48%, OR 0.412, 95% CI 0.190-0.892, P = 0.024; aOR 0.358, 95% CI 0.155-0.828, P = 0.016). The difference in the multiple birth rate was 20.00% without statistical significance. Univariate and multivariate analyses revealed that age (OR 0.759, 95% CI .624-0.922, P = 0.006 and OR 0.751, 95% CI 0.605-0.932, P = 0.009) and the number of transferred embryos (OR 0.412, 95% CI 0.190-0.892, P = 0.024 and OR 0.367, 95% CI 0.161-0.840, P= 0.018) were significant variables for the live birth rate in Poseidon Group 2.
Conclusions: The findings in the present study showed that eSET was preferred in the first frozen cycle for Poseidon Group 1 to avoid unnecessary risks. Double embryo transfer strategy could be considered to improve the success rate for Poseidon Group 2 with caution. Further stratification by age is needed for a more scientific discussion about the embryo transfer strategy for Poseidon patients.
Knowledge Graph Construction based on Granulosa Cells Transcriptome from polycystic ovary syndrome with Normoandrogen and Hyperandrogen
Authors: Liu Wensu , Tang Tianyu , Feng Jianwei , Wang Chunyu , Lin Lin , Wang Shengli , Zeng Kai , Zou Renlong , Yang Zeyu , Zhao Yue
Published: March 2023

PCOS is a widespread disease that primarily caused in-pregnancy in pregnant-age women. Normoandrogen (NA) and Hyperandrogen (HA) PCOS are distinct subtypes of PCOS, while bio-markers and expression patterns for NA PCOS and HA PCOS have not been disclosed. We performed microarray analysis on granusola cells from NA PCOS, HA PCOS and normal tissue from 12 individuals. Afterwards, microarray data were processed and specific genes for NA PCOS and HA PCOS were identified. Further functional analysis selected IL6R and CD274 as new NA PCOS functional markers, and meanwhile selected CASR as new HA PCOS functional marker. IL6R, CD274 and CASR were afterwards experimentally validated on mRNA and protein level. Subsequent causal relationship analysis based on Apriori Rules Algorithm and co-occurrence methods identified classification markers for NA PCOS and HA PCOS. According to classification markers, downloaded transcriptome datasets were merged with our microarray data. Based on merged data, causal knowledge graph was constructed for NA PCOS or HA PCOS and female infertility on NA PCOS and HA PCOS. Gene-drug interaction analysis was then performed and drugs for HA PCOS and NA PCOS were predicted. Our work was among the first to indicate the NA PCOS and HA PCOS functional and classification markers and using markers to construct knowledge graphs and afterwards predict drugs for NA PCOS and HA PCOS based on transcriptome data. Thus, our study possessed biological and clinical value on further understanding the inner mechanism on the difference between NA PCOS and HA PCOS.
METHODS OF TREATMENT OF PATIENTS WITH ARTERIAL HYPERTENSION WITH MANIFESTATIONS OF HYPERVENTILATION SYNDROME
Authors: Zarivna Iryna , Levchenko Valeriy
Published: March 2023

Introduction. Some patients with stage 1 arterial hypertension often have symptoms originating from various anatomic and functional locations in the absence of organic changes associated with manifestations of psychosomatic autonomic dysfunction. Among the manifestations, patients have "respiratory", cardiovascular, abdominal symptoms, as well as the signs of anxiety-depressive syndrome. These signs indicate the presence of comorbid psychosomatic disorders in the patient, which can affect the course of hypertension and the nature of the treatment.
Materials and methods. The screening was carried out in 125 patients with stage 1 AH. Hyperventilating syndrome was detected in 46.40% of them (n = 58) according to the Nijmegen questionnaire; these patients were included in the experimental group. At the same time, standard indicators of hemodynamics, state of anxiety as an additional marker of psychovegetative dysfunctions according to the Spielberger scale were evaluated. The control group consisted of 24 patients with stage 1 AH without signs of hyperventilating syndrome.
By randomization, all patients of the experimental group were divided into 4 groups depending on the treatment: patients from 1st and 2nd group received perindopril and amlessa; 3rd and 4th group – medication in combination with systematic diaphragmatic breathing. The latter provides an anti-stressor effect, normalizes the breathing pattern, eliminates the consequences of hypocapnia and possibly reduces the effect of bradykinin on bronchial tone after taking ACE inhibitors.
Results and discussion. A correlation was found (r = 0.72; p ˂ 0.05) between the severity of hyperventilating syndrome (41.63 ± 0.82) points and indicators of total peripheral vascular resistance (1476.13 ± 42.39) dyn•s•cm-5. The latter was significantly higher than the results obtained in the control group of patients – (1374.62 ± 36.11) dyn•s•cm-5 (р ˂ 0.05). At the same time, the signs of state anxiety comprised (42.96 ± 2.05) points vs. the result in the control group (22.36 ± 1.33) points (р ˂ 0.05). The evaluation of the results of the treatment after 2–3 months revealed a significant advantage of the combined effect of medications and systematic diaphragmatic breathing, which reduced hyperventilation in the 3rd and 4th groups by 12.92% and 15.37% (р ˂ 0.05); state anxiety by 16.73% and 20.31% (р ˂ 0.05), respectively, which was not significant in groups 1–2. In addition, diaphragmatic breathing increased the effect of amlessa. When treating patients with stage 1 hypertensive disease it is recommended to search for the signs of hyperventilating syndrome and prescribe combined therapy which includes diaphragmatic breathing and hypotensive medications.
CLINICAL AND ANAMNESTIC FEATURES OF THE NEWBORNS WITH PERINATAL HIV EXPOSURE
Authors: Puhach Мaryna , Herasymova Оlena
Published: March 2023

Introduction. Maternal HIV infection has many adverse effects, including low birth weight, which is the primary cause of neonatal, infant, and under-five mortality. In the literature, the issue of intrauterine growth restriction (IUGR) in children who were born to HIV-positive mothers is being discussed, and the causes that may be the result of the direct effect of the virus, immunosuppression, or concomitant diseases are being studied. The association between maternal HIV infection and low birth weight (LBW) was not adequately explored and the available studies suggested inconsistent findings.
Objective: to analyze the clinical and anamnestic data of the newborns with perinatal HIV exposure and to assess their physical development according to the gestational age and HIV stage of the mother.
Material and methods. In order to achieve this goal, 34 medical histories of the patients who had been treated in the neonatal center of Vinnytsya Regional Children's Clinical Hospital from 2015 to 2022 with a diagnosis of perinatal HIV exposure were retrospectively analyzed.
Results. According to the results of the study, a third of the children were born prematurely (12 (35 ± 8) %, 95%CI: 27–43 %). Сhildren born to mothers with stage IV of HIV infection had the lowest mean gestational age. When assessing the physical development of newborns according to gestational age, it was established that 9 children ((26 ± 8) %, 95%CI: 18–34 %) were small for gestational age, and 3 children ((9 ± 5) %, 95%CI: 4–14 %) were small-for-date. The lowest body weight values were observed in children born to mothers with stage IV of HIV infection – (1561.42 ± 0.21) g, which significantly differs from the weight of newborns whose mothers had HIV infection of stage I (2550.10 ± 1.51) g and stage II (2646.36 ± 1.69) g, p < 0.05.
Conclusions. Among children with perinatal HIV exposure, there is a risk of premature birth with IUGR. Children born to mothers with stage IV HIV infection had significantly lower gestational age and body weight values.
DIFFERENTIAL DIAGNOSIS OF EXACERBATIONS AND PSEUDO-EXACERBATIONS AGAINST THE BACKGROUND OF SARS-COV-2 BY THE EXAMPLE OF A CLINICAL CASE OF A PATIENT WITH MULTIPLE SCLEROSIS
Authors: Lychko Volodymyr , Kolenko Oksana , Burtyka Mykola
Published: March 2023

Abstract. Due to the COVID-19 pandemic, there is an increasing need for information on how SARS-CoV-2 affects individuals with multiple sclerosis (MS). The patients receiving disease-modifying therapy (DMT) for MS are more likely to require medical attention for infection than the general population. SARS-CoV-2 can cause the worsening of MS symptoms and be mistaken for a relapse, so physicians must carefully assess whether a patient is experiencing a relapse or pseudo-exacerbation. Thus, there is a necessity for science-based guidelines on how to lower the risk of infection, as well as an early differential diagnosis of relapse and pseudo-exacerbation, and effective care for MS patients with COVID-19.
Materials and methods of research: a patient with a history of MS treated with DMTs. The patient presented with worsening disease symptoms, likely exacerbation, and was diagnosed with COVID-19.
Results: a thorough analysis of existing literature was conducted, along with a quick examination of how DMT was used in MS patients with COVID-19. The patient we dealt with was receiving DMT and experienced a severe illness. Timely use of intravenous corticosteroids and antibiotics allowed taking under control the activity of the pathological process. Fortunately, the outcome was favorable.
Conclusions: this evaluation presents information about the clinical features, results, and functions of DMTs in MS patients infected with SARS-CoV-2. Healthcare professionals must carefully consider the possibility of relapse in MS patients with COVID-19, particularly during the pandemic, and should look out for pseudo-exacerbations. While many cases demonstrated a mild course of illness and successful recovery with DMTs, additional investigation is required to create guidelines supported by evidence.
Dança e participação: o caso dos homens estudantes do curso de licenciatura em educação física UFV/CAF
Authors: COSTA Bárbara , SILVA Marcília
Published: March 2023

Estereótipos sociais e culturais dificultam a participação masculina na dança. Desta forma, o presenteestudo tem como objetivos entender as limitações e motivações para a participação de estudantes homens do curso de Licenciatura em Educação Física da Universidade Federal de Viçosa - Campus Florestal (UFV-CAF) no Projeto Movimento e Saúde-#Dance/UFV e compreender as concepções de dança dos mesmos. Utilizou-se um questionário semiestruturado enviado via e-mail aos participantes, para posterior analise qualitativa das respostas. Apesar de muitos estudantes reconhecerem a importância de se trabalhar o conteúdo da dança, a falta de segurança se apresenta como barreira para que ministrem uma aula sobre o tema. Apesar de barreiras histórico-sociais, o preconceito não apareceu nos resultados como um fator limitante para maior parte dos entrevistados, levando a reflexão acerca de outras possibilidades, como a divulgação do projeto e o horário que o mesmo ocorria, no contraturno do curso.
Prevalence and Risk Factors of Hepatitis B Virus Infection among a Cohort of Primary Health Care Workers in Nigeri
Authors: Anthony Orji Ikechukwu
Published: March 2023

Hepatitis B Virus (HBV) infection is one of the most infectious diseases globally. Nigeria is among the endemic countries for HBV, with a National prevalence of 11%. The Primary Healthcare Center (PHC) is critical for interrupting the transmission of HBV infection. Consequently, the baseline information concerning the prevalence, associated risk factors, and vaccination status of the health workers for HBV is required for the system strengthening, hence, the need for this study. To determine the prevalence of HBV among health workers in PHCs in AMAC, Abuja. 2. To identify the risk factors associated with HBV infection amongst this cohort. A hospital-based cross-sectional descriptive study involving 168 randomly selected PHC health workers. Data was collected with a structured questionnaire, and participants were screened for HBsAg. Data were analyzed using SPSS version 21.0 with results significant at p-value < 0.05. 168 respondents participated in the study, 65.5% were females, and the mean age was 34 +/- 9 years. The full vaccination rate was 44%, while the prevalence of HBV infection was 4.8%. The history of dental procedure was the only significant predictor of HBV infection, and those who had the dental procedure were thrice more likely to be infected with HBV than their counterparts (OR: 3.077). The prevalence of HBV in this study is low, per, National prevalence, but high for this cohort of health workers with a considerable Hepatitis B vaccination rate. There is a need to strengthen health workers' HBV screening and vaccination in addition to improving infection prevention and control in dental clinics/surgeries. Keywords: HBV Infection, Health-worker, Primary Healthcare Center, Prevalence, Risk Factors.
The Use of Herbal Health Products and Home-Based Remedies for Protection Against Covid-19
Authors: Fagbola Olalekan
Published: March 2023

Natural medicinal products and home-based remedies have been in use for centuries by people across the world. Tradition, belief, cultural practice, and previous experience are associated with the use of herbal products. The trend is observed to be on the increase since covid-19 Pandemic hit the global stage. In the early days of the Pandemic, people protected themselves by practicing measures that would safeguard them from getting infected with the deadly virus. This study evaluated prevalence, risks, harms, benefits, and other issues associated with using herbs and home-based remedies to prevent and treat Covid-19. It highlights various measures of prevention and treatment practiced by employees and customers of a Regional Corporation by capturing the demographic characteristics, reasons, and associated factors for using alternative medical products. A descriptive cross-sectional survey in a hybrid online was carried out from February 2022 to April 2022. Data of independent and dependent variables was collected using a well-structured hybrid (online and paper and pencil) questionnaire. Prevalence of steam inhalation was 51%, essential oils, including menthol crystal vapour inhalation, was 61%, herbal supplements was 20.6%, and natural health products was 100% (n = 286). Non-allopathic medicinal products, home-based remedies, and other preventive health measures were on the increase in prevalence during covid-19 Pandemic. Large studies are required to assess the efficacy and safety of herbal supplements and home-based remedies to protect users from unnecessary dangers inherent in their use. Keywords: Covid-19 pandemic, Herbal health supplements, Home-based remedies, Infection, Prevalence, Natural products, Regional corporation.