bluuebunny/crossref_metadata_2025 huggingface dataset:
ROLE OF INTERVENTION STRATEGIES AND PSYCHOLOGICAL EFFECT ON THE CONTROL OF INFECTIOUS DISEASES IN THE RANDOM ENVIRONMENT
Authors: BELABBAS MUSTAPHA , SOUNA FETHI , TIWARI PANKAJ KUMAR , MENACER YOUSSAF
Published: July 2024

Infectious disease outbreaks have caused significant losses to populations worldwide in terms of morbidity, social and economic costs. This has prompted governments to seek suitable intervention policies to suppress the outbreaks. This paper aims to explore the intrinsic impact of intervention strategies and the psychological behavior of people on the spread of infectious diseases. Employing the finite state Markov chain, we formulate a new stochastic SIS epidemic model under regime switching by using the Beddington–DeAngelis transmission function, in the presence of some governmental control measures. The study of the model is centered on three different scenarios in terms of varying two control parameters. We analyze the deterministic system for the global dynamics in terms of basic reproductive number. Some new threshold parameters are defined to discuss the extinction and the persistence of the disease in the stochastic setting. Numerical assessments were undertaken to validate theoretical findings for the deterministic and stochastic systems. Our findings strongly suggest that heightened awareness among susceptible individuals contributes significantly to the eradication of infection and fosters a stable epidemiological situation. As levels of public awareness increase, particularly within the susceptible population, a discernible trend toward the eradication of the infection emerges, ultimately ensuring sustained stability within the epidemiological landscape.
Weighted differential (q-tri)dendriform algebras
Authors: Zhang Yuanyuan , Zhang Huhu , Wu Tingzeng , Gao Xing
Published: July 2024

In this paper, we first introduce a weighted derivation on algebras over an operad [Formula: see text], and prove that for the free [Formula: see text]-algebra, its weighted derivation is determined by the restriction on the generators. As applications, we propose the concept of weighted differential ([Formula: see text]-tri)dendriform algebras and study some basic properties of them. Then Novikov-(tri)dendriform algebras are initiated, which can be induced from differential ([Formula: see text]-tri)dendriform of weight zero. Finally, the corresponding free objects are constructed, in both the commutative and noncommutative contexts.
Outcomes of Arthroscopic Debridement of the First Carpometacarpal Joint: A Systematic Review
Authors: SHEHOVYCH Andrew , LAWSON Richard , GRAHAM David J. , SIVAKUMAR Brahman S.
Published: July 2024

Background: Arthroscopic debridement is increasingly being utilised in patients with early-stage first carpometacarpal joint (FCMCJ) arthritis but has limited supportive evidence. This systematic review evaluates the literature, and reports on outcomes and adverse events following this procedure.

Methods: An electronic literature search of PubMed, Embase, Medline and Cochrane Central, looking for studies describing outcomes following arthroscopic debridement in FCMCJ arthritis, was performed in November 2022. Studies where bony resection or interposition was performed as adjuncts were excluded. Reported outcomes included visual analogue scores (VAS) for pain; Disabilities of Arm, Shoulder and Hand (DASH) scores; pinch and grip strength; complications and re-operations.

Results: Out of a total of 90 studies revealed from the search, only two studies were eligible for inclusion, with a cohort of 34 patients. Following arthroscopic debridement for FCMCJ osteoarthritis, the mean VAS improved by four units, mean DASH by 22 points, grip strength by 4.5 kg and pinch strength by 2 kg at mean follow-up of 18 months. The pooled complication and re-operation rates were 8.8% and 23.5%, respectively.

Conclusions: There is a lack of evidence supporting the utility of FCMCJ arthroscopy and debridement in the management of patients with early arthritis. Although the limited evidence suggests that there may be some therapeutic benefit, further large-scale prospective studies need to be performed before making conclusive recommendations.

Level of Evidence: Level III (Therapeutic)
Perilunate Fracture–Dislocation: Results at Mean Follow-Up of 7 Years after ORIF
Authors: BENSEDDIK Anisse , CHOLLEY-ROULLEAU Martin , DAP François , ATHLANI Lionel
Published: July 2024

Background: Perilunate fracture–dislocations are frequently associated with a high risk of developing post-traumatic arthritis. Current studies indicate that during mid-term follow-ups, radiological signs of arthritis do not appear to correspond with functional score. The aim of this study was to assess the occurrence of posttraumatic arthritis and the wrist function after perilunate dislocations (PLD) and fracture dislocations at a mid-term follow-up of 7 years.

Methods: We report the clinical and radiological outcomes of 17 wrists treated for PLD or fracture–dislocation by open reduction and internal fixation through a dorsal approach with dorsal ligament repair. Functional outcomes were evaluated using the short version of the Quick Disabilities of the Arm, Shoulder and Hand questionnaire (QuickDASH), the Patient-Rated Wrist Evaluation questionnaire (PRWE) and the Mayo Wrist Score (MWS). Results of radiographs were assessed using the Herzberg Radiological Scoring Chart.

Results: The MWS showed five excellent, five good, five fair and two poor results with an average score of 81%. Radiological analysis using the Herzberg classification revealed midcarpal and/or radiocarpal arthritis in 65% of cases, lunate collapse in 59% and an increase in the mean ulnar translocation ratio in 53% of the cases. Complications included one case of lunate osteonecrosis and one case of stage 3 scapholunate advanced collapse that required revision surgery.

Conclusions: Although the clinical and functional outcomes are favourable at mid-term follow-up, radiological evaluation shows a progression towards osteoarthritis (OA). Further research is warranted to refine treatment strategies and investigate factors influencing the development of OA.

Level of Evidence: Level IV (Therapeutic)
A Systematic Review and Network Meta-Analysis of Randomised Controlled Trials Comparing Treatments for Displaced Radial Head Fractures
Authors: HAINES Samuel , ABDELMALEK Amir , AKEHURST Harold , AMIRFEYZ Rouin
Published: July 2024

Background: The aim of this study is to compare the surgical and non-operative management of displaced radial head fractures via a network meta-analysis of randomised controlled trials (RCTs).

Methods: RCTs comparing management of isolated, displaced radial head fractures in adults were included in our review and statistical analysis. A systematic review of electronic databases (Medline, Embase and Cochrane Library) were screened for comparative RCTs reporting on the management of displaced radial head fractures in August 2021. Two investigators independently reviewed studies for eligibility and an assessment of bias was performed for each study. A Bayesian network meta-analysis of the included RCTs was performed.

Results: Five RCTs (326 patients) were included in our meta-analysis. Treatment methods included radial head arthroplasty (RHA), open reduction internal fixation (ORIF) with metal implants (ORIF-M), ORIF with biodegradable implants (ORIF-B) and non-operative management. In our network meta-analysis of ‘good’ or ‘excellent’ patient-reported outcome measures (PROMs), RHA was significantly favourable to ORIF-M (OR: 0.04, CrI: 0.0011, 0.87), ORIF-B (OR: 0.1 CrI: 0.00076, 6.37). Nonoperative treatment was not shown to be significantly worse than RHA (OR: 0.01 CrI: 2.5e–0.5, 3.61).

Conclusions: This network meta-analysis shows that in displaced radial head fractures, RHA is associated with significantly superior functional PROMs than ORIF-M based on the evidence available. Nonoperative management has not been shown to be significantly worse.

Level of Evidence: Level III (Therapeutic)
Extraskeletal Ewing Sarcoma Disguised as a Vascular Malformation
Authors: GIRI Sanjay Kumar , RAJPOOT Akanksha , SUBA Santanu
Published: July 2024

Extraskeletal Ewing sarcoma (EES) is a rare entity, accounting for only 3% of lesions encountered in upper extremity. We present two paediatric patients, who were initially diagnosed with a vascular malformation based on clinical assessment and imaging. Final histopathology revealed Ewing sarcoma of soft tissue origin, confirmed by immunohistochemical analysis. Hand surgeons, who are routinely approached for a myriad of hand pathologies, should be wary and consider EES as a differential when treating such lesions. A multidisciplinary approach with an appropriate treatment algorithm can help in a speedy diagnosis, improving the long-term prognosis of the disease.

Level of Evidence: Level V (Therapeutic)
Primary Reconstruction Using Fibular Strut Allograft for Distal Humerus Intra-articular Comminuted Open Fracture (AO/OTA13C2, G-A type IIIA): A Case Report
Authors: LEE Bumseok , OH Jin Rok
Published: July 2024

Distal humerus intra-articular comminuted open fracture is a challenging injury, with nonunion, infection and stiffness considered as major concerns. We report a 58-year-old woman who was admitted to the emergency department from a car accident, sustaining an open wound with severe comminution of distal humerus and complete articular fracture, classified as AO/OTA 13C2 and Gustillo Anderson type IIIA. Debridement and external fixation was done first, followed by open reduction and internal fixation with fibular strut allograft. The patient showed excellent results in radiological and functional outcomes.

Level of Evidence: Level V (Therapeutic)
Elemental Mercury Poisoning by Self-Injection – A Report of Two Cases
Authors: CHANDRAN Aswathy , RAJAN T. M. Sheeja , MENEDAL Akshata , RAJASUBRAMANYA Priyavrata
Published: July 2024

Injection of mercury into the upper limb is a rare method of self-harm. We report two patients with varied clinical presentations – a 19-year-old male student who injected himself with mercury extracted from a sphygmomanometer bulb and reported to our emergency department 24 hours after the event and a 34-year-old industry worker who presented 2 years after injecting himself with elemental mercury. The management of mercury poisoning is described along with a brief review of literature. Mercury is a toxic element and adequate safety precautions must be taken by the surgical team in the management of such patients.

Level of Evidence: Level V (Therapeutic)
Deep Learning-based Depth Estimation Methods from Monocular Image and Videos: A Comprehensive Survey
Authors: Rajapaksha Uchitha , Sohel Ferdous , Laga Hamid , Diepeveen Dean , Bennamoun Mohammed
Published: July 2024

Estimating depth from single RGB images and videos is of widespread interest due to its applications in many areas, including autonomous driving, 3D reconstruction, digital entertainment, and robotics. More than 500 deep learning-based papers have been published in the past 10 years, which indicates the growing interest in the task. This paper presents a comprehensive survey of the existing deep learning-based methods, the challenges they address, and how they have evolved in their architecture and supervision methods. It provides a taxonomy for classifying the current work based on their input and output modalities, network architectures, and learning methods. It also discusses the major milestones in the history of monocular depth estimation, and different pipelines, datasets, and evaluation metrics used in existing methods.
SmartExecutor: Coverage-Driven Symbolic Execution Guided via State Prioritization and Function Selection
Authors: Wei Qiping , Sikder Fadul , Feng Huadong , Lei Yu , Kacker Raghu , Kuhn Richard
Published: July 2024

Symbolic execution of smart contracts suffers from sequence explosion. Some existing tools limit the sequence length, thus being unable to adequately evaluate some functions. In this article, we propose a symbolic execution approach without limiting the sequence length. In our approach, the symbolic execution process is a two-phase model that maximizes code coverage while reducing the number of sequences to be executed. The first phase executes all sequences up to a length limit to identify the not-fully covered functions, while the second attempts to cover these functions according to state evaluation and a function graph structure. We have developed a tool called SmartExecutor and conducted an experimental evaluation on the SGUARD dataset. The experimental results indicate that compared with state-of-the-art tools, SmartExecutor achieves higher code coverage with less time. It also detects more vulnerabilities than Mythril, a state-of-the-art symbolic execution tool.
Periplasmic Chaperones: Outer Membrane Biogenesis and Envelope Stress
Authors: Combs Ashton N. , Silhavy Thomas J.
Published: July 2024

Envelope biogenesis and homeostasis in gram-negative bacteria are exceptionally intricate processes that require a multitude of periplasmic chaperones to ensure cellular survival. Remarkably, these chaperones perform diverse yet specialized functions entirely in the absence of external energy such as ATP, and as such have evolved sophisticated mechanisms by which their activities are regulated. In this article, we provide an overview of the predominant periplasmic chaperones that enable efficient outer membrane biogenesis and envelope homeostasis in Escherichia coli. We also discuss stress responses that act to combat unfolded protein stress within the cell envelope, highlighting the periplasmic chaperones involved and the mechanisms by which envelope homeostasis is restored.
A First-Principles Study on the Anchoring Properties of Defective Single-Walled Carbon Nanotubes for Lithium-Sulfur Batteries
Authors: Zhu Tianjiao , Hao Xiaoqian , Cao Yongan , Li Yuqian , Wang Wenju
Published: July 2024

The application of lithium-sulfur (Li–S) batteries is impeded by the significant polysulfide shuttling phenomenon. Developing suitable anchoring material is an effective way to restrain this behavior. In this work, the anchoring performance of lithium polysulfide (LiPSs) on defective single-wall carbon nanotubes (DSWNT) is investigated by density functional theory. The results demonstrate that the DSWNT with three carbon vacancies (DSWNT-3) has the highest forming capacity and the strongest adsorption capacity, indicating it has the best anchoring effect of LiPSs. As the anchoring material of the cathode, DSWNT-3 has greater energy than solvent molecules to inhibit the dissolution of long-chain polysulfides. In general, DSWNT-3 demonstrates notable efficacy as an anchoring material for Li–S batteries, which establishes a theoretical foundation for exploring the anchoring characteristics of defects and their application in the cathode of Li–S batteries.
Parameter Regression for Porous Electrodes Employed in Lithium-Ion Batteries and Application to Ni0.89Co0.05Mn0.05Al0.01O2
Authors: Baker Daniel R. , Verbrugge Mark W. , Koch Brian J.
Published: July 2024

We develop a parameter regression scheme that can be used with battery models of interest to the battery-analysis community. We show that the recent reduced order model (ROM1, 2022 J. Electrochem. 169 070520, DOI: 10.1149/1945–7111/ac7c93), which is based on a perturbation solution, can be used in place of the full system of nonlinear partial differential equations with minimal loss of accuracy for the conditions of this work, which are relevant for electric vehicle applications. The use of the computationally efficient ROM1, cast in the Python programming language, along with a routine native to Python for the nonlinear regression of model parameters through the minimization of the squared differences between experimental results and model calculations, provides a fast method for the overall endeavor. We apply the procedure to examine Ni0.89Co0.05Mn0.05Al0.01O2, a high-capacity material that is of increasing interest with respect to electric vehicles and other products that rely on batteries of high energy density. Difficulties encountered in this work include the large number of parameters governing the battery model, parameter sensitivity in the regression analyses, and the potential for multiple solutions. We close this publication with a discussion of these challenges and open questions with respect to parameter identification.
Impact of Different Amounts of Lithium Plating on the Thermal Safety of Lithium Ion Cells
Authors: Timke Bennet , Winter Martin , Niehoff Philip
Published: July 2024

Safety tests are usually conducted on fresh cells. However, occurring lithium plating for example due to harsh aging conditions or electrode inhomogeneities can negatively affect the thermal properties of cells over their lifespan. Recent literature studies showed serious deterioration of the thermal cell properties due to lithium plating while other studies showed no impact at all. These differences are at least partly explained by different amounts of metallic lithium. Here, the impact of the amount of lithium plating on the thermal cell properties was investigated. 1 Ah LiNi0.8Co0.1Mn0.1O2 (NMC811)||artificial graphite pouch cells were aged at 0 °C between zero and ten cycles. The amount of lithium plating was found to influence the self-heating-rates reached during the initial phase of a thermal safety experiment, but did not have a major impact on the safety at higher temperatures. Despite the presence of lithium plating of up to 15% of the initial capacity, none of the cells showed exothermic self-heating for more than three consecutive measuring points below 85 °C. An impact on the onset temperature of first permanent exothermic reactions could only be reliably detected if a cell had already suffered from 10% capacity loss due to lithium plating.
Zinner Syndrome: The Diagnosis and Management of a Rare Urogenital Malformation
Authors: Lau Lucinda , Patel Kishan S. , Santisi Frank , Germaine Rebecca , Jeph Sunil
Published: July 2024

This case highlights an atypical but important consideration in young males presenting with persistent gastrointestinal and/or genitourinary symptoms. Zinner syndrome (ZS) develops from embryologic maldevelopment of the distal mesonephric duct, resulting in ejaculatory duct atresia with consequent obstruction of the seminal vesicle and concomitant ureteral bud malformation, leading to renal agenesis/dysplasia. The lack of distinct clinical symptoms makes ZS a difficult diagnosis to reach: Abdominal pain and dysuria are often mistaken for prostatitis or cystitis. However, the use of modern imaging modalities aids in establishing the diagnosis. Early identification of ZS may delay progression to infertility as the duct obstruction may not be as extensive, though further research is needed to establish this connection.
Sociodemographic Profile and Risk Factors for the Evolution of Patients with COVID‐19 in ICUs in Brazil: A Cross‐Sectional Study
Authors: Fernandes Lira Joelma Greicy , Alves de Olinda Ricardo , Correia Basto da Silva Gustavo , Leal de Oliveira Luzibênia , Alencar Neta Raimunda Leite de , Vilar Cardoso Nívea , Adami Fernando , da Silva Paiva Laércio
Published: July 2024

This is a cross‐sectional study, with secondary data from Brazilian hospitals in the state of Paraíba, between January 2021 and January 2022. The evolution of clinical cases configured the dependent variable (cure or death), while the predictive variables were sociodemographic data, risk factors, use of ventilatory support, and vaccination against COVID‐19. With the help of R software, the following tests were used: chi‐square, Pearson’s chi‐square, and Fisher’s exact adherence. Simple logistic regression models were constructed, and odds ratios (95% CI) were estimated using the LR test and Wald test. 7373 cases were reported, with a mean age of 58.1. Of the reported cases, 63.8% died. The most frequent sociodemographic profile included male people, of mixed race, with less than eight years of schooling. Chronic cardiovascular disease (OR 1.28; 95% CI: 1.13–1.45), diabetes (OR 1.41; 95% CI: 1.24–1.61), lung disease (OR 1.52; 95% CI: 1.11–2.09), and the use of invasive ventilatory support (OR 14.1; 95% CI: 10.56–18.59) were all associated with increased mortality. Nonvaccination was associated with a decreased risk of death (OR 0.74; 95% CI: 0.65–0.84). Male patients, nonwhite, and those with low education were more likely to have a worse clinical outcome. The risk factors studied were related to deaths, and those who did not require ventilatory support were related to cure.
Supporting Adolescents and Young Adults through Digitally Mediated Type 1 Diabetes Transition Care: A Qualitative Descriptive Study
Authors: El-Dassouki Noor , Taylor Madison , Pfisterer Kaylen J. , Saragadam Ashish , Nakhla Meranda , Greenberg Marley , Landry Alanna , Mukerji Geetha , Mok Elise , Brazeau Anne-Sophie , Kichler Jessica C. , Cafazzo Joseph A. , Shulman Rayzel
Published: July 2024

Objective. The time during which adolescents and young adults (AYAs) living with Type 1 Diabetes (T1D) transition from pediatric to adult care is associated with blood sugar levels outside of target ranges, care gaps, and an increased risk of acute diabetes complications. The aim of this study was to understand (1) the perspectives of AYAs and providers about the strengths, challenges, and opportunities of transition care and (2) the role of digital technologies in supporting the transition to adult care. Research Design and Methods. We conducted a qualitative descriptive study that involved 43 semistructured interviews in French or English with AYA living with T1D (aged 16–25; n = 22) and pediatric or adult diabetes health care providers (HCPs) (n = 21). Results. We identified three themes. First, transition care is not standardized and varies widely, and there is a lack of awareness of transition guidelines. Second, virtual care can simultaneously hinder and help relationship‐building between providers and AYA. Third, AYAs value a holistic approach to care; both HCPs and AYA highlighted the opportunity to better support overall mental wellbeing. Conclusions. The design of digital technologies to support T1D transition care should consider methods for standardizing holistic care delivery and integrating hybrid diabetes care visits to support access to transition care. These findings can inform future transition intervention development that leverages existing transition guidelines, targets holistic care model integration, and considers quantitative diabetes metrics in conjunction with broader life experiences of AYA when providing transition care.
Gut Microbiota and Metabolic Syndrome: Relationships and Opportunities for New Therapeutic Strategies
Authors: Ezenabor Emmanuel Henry , Adeyemi Aishat Abimbola , Adeyemi Oluyomi Stephen
Published: July 2024

Since its discovery, numerous studies have shown the role of the microbiota in well‐being and disease. The gut microbiota represents an essential factor that plays a multidirectional role that affects not just the gut but also other parts of the body, including the brain, endocrine system, humoral system, immune system, and metabolic pathways, as well as host‐microbiome interactions. Through a comprehensive analysis of existing literature using the desktop research methodology, this review elucidates the mechanisms by which gut microbiota dysbiosis contributes to metabolic dysfunction, including obesity, dyslipidaemia, hypertension, atherosclerosis, hyperuricemia, and hyperglycaemia. Furthermore, it examines the bidirectional communication pathways between gut microbiota and host metabolism, highlighting the role of microbial‐derived metabolites, immune modulation, and gut barrier integrity in shaping metabolic homeostasis. Importantly, the review identifies promising therapeutic strategies targeting the gut microbiota as potential interventions for metabolic syndrome, including probiotics, prebiotics, symbiotics, dietary modifications, and faecal microbiota transplantation. By delineating the bidirectional interactions between gut microbiota and metabolic syndrome, the review not only advances our understanding of disease pathophysiology but also underscores the potential for innovative microbiota‐based interventions to mitigate the global burden of metabolic syndrome and its associated complications.
Evaluation of the Urine POC‐CCA Test Accuracy in the Detection of Schistosoma mansoni Infection: A Systematic Review and Meta‐Analysis
Authors: Alemu Getaneh , Nibret Endalkachew
Published: July 2024

Background. Schistosomiasis is a common public health problem throughout the world and Schistosoma mansoni is the most prevalent species in Africa. Most endemic countries use the Kato–Katz (KK) stool smear examination for diagnosis, mapping, and monitoring of intervention programs. However, its poor sensitivity calls for an urgency to evaluate and use more accurate diagnostic tools, of which detection of circulating cathodic antigen (CCA) in urine seems promising. Methods. Studies published until May 2022 were searched from PubMed, Google Scholar, and grey literature for systematic review and meta‐analysis following the PRISMA guideline. Eligible studies were selected based on preset inclusion and exclusion criteria. Quality of included studies was assessed using the QUADAS‐2 tool. Heterogeneity between studies was assessed using Cochrane Q test and I2 test statistics. Data were analyzed using Review Manager 5.4.1 and Meta‐DiSc 1.4 software programs. Results. Thirty‐seven studies published in 29 papers and enrolling 21159 study participants were included for analysis. Overall analysis of Point‐of‐Care Circulating Cathodic Antigen (POC‐CCA) test against KK reference standard revealed a pooled sensitivity and specificity of 0.86 (95% CI: 0.85–0.87) and 0.66 (95% CI: 0.65–0.67), respectively. Subgroup analysis among 24 studies comparing single POC‐CCA with test single KK revealed a high sensitivity (0.88) but low specificity (0.66). Based on findings of 24 studies, the area under the curve (AUC) for the systematic receiver operating characteristic (SROC) curve was 0.7805, indicating that the POC‐CCA test effectively separates those with the disease from those who do not have it. Higher sensitivity estimates of 0.93 and 0.90 were reported when comparisons were made between test results of 2 urine and 1 stool samples, and 3 urine and 3 stool samples, respectively. Single POC‐CCA test resulted in a pooled sensitivity estimate of 0.81 (95% CI: 0.78–0.84) as evaluated by the polymerase chain reaction (PCR) reference test. Conclusions. The POC‐CCA test has higher sensitivity than KK and may serve as a routine diagnostic alternative for disease diagnosis, mapping, and monitoring of interventions. However, its accuracy should further be evaluated at different transmission settings and infection intensity.
Bangana devdevi, a Native Carp of the Himalayan Biodiversity Hotspot: Reproductive Biology and Hormonal Breeding Efforts for Conservation and Aquaculture Promotion
Authors: Bedajit Yumnam , Irungbam Surajkumar , Ngasotter Soibam , Waikhom David , Meitei Maibam Malemngamba , Singh Sanjenbam Bidyasagar , Devi Wangkheimayum Malemnganbi , Singh Soibam Khogen , Das Pronob , Singh Soibam Basanta
Published: July 2024

Efficient conservation efforts for valued fish species such as Bangana devdevi, a medium‐sized minor carp prevalent in Southeast Asian countries, can be facilitated through well‐established artificial breeding techniques. This study aimed to investigate the reproductive biology of B. devdevi and focused on optimizing hormone dosages for breeding purposes for the first time. The research findings indicated that the highest gonadosomatic index (GSI) for males (1.17) was observed in August, while for females, it peaked in July (2.24). Female fish exhibited absolute fecundity ranging from 2089 to 26287 eggs, corresponding to body weights ranging between 10.46 and 153.73 g. The relative fecundity ranged from 170 to 298 eggs g−1 of body weight. To induce breeding, female brooders were administered Gonopro‐FH hormone through three experimental groups: G‐FH_0.4, G‐FH_0.5, and G‐FH_0.6, with doses of 0.4 mL, 0.5 mL, and 0.6 mL·kg−1 of body weight, respectively. Spawning occurred within 6–10 h after hormone administration. Among these groups, G‐FH_0.5 exhibited the highest fertilization rate (94.25%) and hatching rate (89.03%), significantly surpassing the rates observed in G‐FH_0.4 and G‐FH_0.6 (p < 0.05). This study provided valuable insights into the reproductive biology of B. devdevi and emphasized its potential application in developing management and conservation strategies for this species in rivers and tributaries. Furthermore, the knowledge gained from induced breeding holds promise for future large‐scale seed production initiatives.
Health Information Needs of Breast Cancer Survivors: An Umbrella Review
Authors: Gavili Nahid , Sedghi Shahram , Panahi Sirous , Razmgir Maryam
Published: July 2024

Purpose. The aim of this umbrella review was to identify the main information needs of breast cancer survivors. Since several reviews have already been done on this topic, conducting an umbrella review not only combines their results but also gives a comprehensive picture and informative summary of breast cancer survivors’ needs. Method. The search was performed in PubMed, Embase, Scopus, Web of Science, ProQuest, Cochrane, and Google Scholar from inception to the end of March 2024. This review was conducted according to the JBI methodology for umbrella reviews, and the report was based on Rutten’s category for information needs of patients with cancer. After removing duplicate and irrelevant articles, 14 systematic reviews were included in the analysis. The JBI checklist was used for evaluating the quality of eligible articles. Results. The information needs were classified into 11 main categories and 86 subcategories. As a result of this umbrella review, one category was added to Rutten’s 10 categories. Also, treatment information needs were introduced as the main identified category. Information on supportive care needs ranked second, and body image/sexuality information needs ranked third with a slight difference. Conclusion. The information needs outlined in the present study can serve as a general model to help clinical decision makers and policymakers in order to better understand the needs of the group and meet the information needs of the population. Implications for Cancer Survivors. These recommendations can promote and develop targeted interventions to reduce the psychosocial consequences of breast cancer survivors and increase their quality of life.
Enhancing Real‐Time Embedded System Education With Self‐Driving Car Models
Authors: Mustafa Dheya , Khabour Safaa Mahmoud , Mustafeh Intisar Ghazi
Published: July 2024

The self‐driving car has been developing rapidly over the past decade, with increased attention from both academia and industry worldwide. Specialized research labs are equipped with vehicles fully loaded with cutting‐edge technologies. Such labs are very expensive and not accessible to students in developing economies. This work proposes using self‐driving car models to enhance real‐time/embedded system education. We have built two experimental low‐cost self‐driving robotic systems designed specifically for the classroom within an educational context. Lego Mindstorms and Arduino platforms were used as they both offer vast teaching opportunities based on interdisciplinary project‐based learning. The programming languages used are compatible with professional robotic programming languages. The goals of using the proposed models as autonomous cars were, on the one hand, to encourage students to gain hands‐on experiences in the field of mobile robotics and, on the other, to teach senior students programming, problem‐solving, real‐time systems, and embedded systems. The models successfully attracted students and motivated them to be engaged in classroom activities. Using the proposed models, real‐world autodrive features exposed to automated vehicles were implemented and validated.
Fig. S1 from Metabolic Reprogramming Is an Initial Step in Pancreatic Carcinogenesis That Can Be Targeted to Inhibit Acinar-to-Ductal Metaplasia
Authors: Neuß Thorsten , Chen Min-Chun , Wirges Nils , Usluer Sinem , Oellinger Rupert , Lier Svenja , Dudek Michael , Madl Tobias , Jastroch Martin , Steiger Katja , Schmitz Werner , Einwächter Henrik , Schmid Roland M.
Published: July 2024

Glycolysis is upregulated during ADM in vivo
Supplementary Data from IL1R2 Blockade Alleviates Immunosuppression and Potentiates Anti-PD-1 Efficacy in Triple-Negative Breast Cancer
Authors: Xia Jie , Zhang Lixing , Peng Xilei , Tu Juchuanli , Li Siqin , He Xueyan , Li Fengkai , Qiang Jiankun , Dong Haonan , Deng Qiaodan , Liu Cuicui , Xu Jiahui , Zhang Rui , Liu Quentin , Hu Guohong , Liu Chong , Jiang Yi-Zhou , Shao Zhi-Ming , Chen Ceshi , Liu Suling
Published: July 2024

Table S1
Figure S3 from IL1R2 Blockade Alleviates Immunosuppression and Potentiates Anti-PD-1 Efficacy in Triple-Negative Breast Cancer
Authors: Xia Jie , Zhang Lixing , Peng Xilei , Tu Juchuanli , Li Siqin , He Xueyan , Li Fengkai , Qiang Jiankun , Dong Haonan , Deng Qiaodan , Liu Cuicui , Xu Jiahui , Zhang Rui , Liu Quentin , Hu Guohong , Liu Chong , Jiang Yi-Zhou , Shao Zhi-Ming , Chen Ceshi , Liu Suling
Published: July 2024

Supplementary Figure S3
Figure S1 from IL1R2 Blockade Alleviates Immunosuppression and Potentiates Anti-PD-1 Efficacy in Triple-Negative Breast Cancer
Authors: Xia Jie , Zhang Lixing , Peng Xilei , Tu Juchuanli , Li Siqin , He Xueyan , Li Fengkai , Qiang Jiankun , Dong Haonan , Deng Qiaodan , Liu Cuicui , Xu Jiahui , Zhang Rui , Liu Quentin , Hu Guohong , Liu Chong , Jiang Yi-Zhou , Shao Zhi-Ming , Chen Ceshi , Liu Suling
Published: July 2024

Supplementary Figure S1
Data from IL1R2 Blockade Alleviates Immunosuppression and Potentiates Anti-PD-1 Efficacy in Triple-Negative Breast Cancer
Authors: Xia Jie , Zhang Lixing , Peng Xilei , Tu Juchuanli , Li Siqin , He Xueyan , Li Fengkai , Qiang Jiankun , Dong Haonan , Deng Qiaodan , Liu Cuicui , Xu Jiahui , Zhang Rui , Liu Quentin , Hu Guohong , Liu Chong , Jiang Yi-Zhou , Shao Zhi-Ming , Chen Ceshi , Liu Suling
Published: July 2024

Abstract
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited therapeutic options. IL1 receptor type 2 (IL1R2) promotes breast tumor–initiating cell (BTIC) self-renewal and tumor growth in TNBC, indicating that targeting it could improve patient treatment. In this study, we observed that IL1R2 blockade strongly attenuated macrophage recruitment and the polarization of tumor-associated macrophages (TAM) to inhibit BTIC self-renewal and CD8+ T-cell exhaustion, which resulted in reduced tumor burden and prolonged survival in TNBC mouse models. IL1R2 activation by TAM-derived IL1β increased PD-L1 expression by interacting with the transcription factor Yin Yang 1 (YY1) and inducing YY1 ubiquitination and proteasomal degradation in both TAMs and TNBC cells. Loss of YY1 alleviated the transcriptional repression of c-Fos, which is a transcriptional activator of PDL-1. Combined treatment with an IL1R2-neutralizing antibodies and anti-PD-1 led to enhanced antitumor efficacy and reduced TAMs, BTICs, and exhausted CD8+ T cells. These results suggest that IL1R2 blockade might be a strategy to potentiate immune checkpoint blockade efficacy in TNBC to improve patient outcomes.

Significance: IL1R2 in both macrophages and breast cancer cells orchestrates an immunosuppressive tumor microenvironment by upregulating PD-L1 expression and can be targeted to enhance the efficacy of anti-PD-1 in triple-negative breast cancer.
Supplementary Figure S4 from Biomarker Identification and Risk Prediction Model Development for Differentiated Thyroid Carcinoma Lung Metastasis Based on Primary Lesion Proteomics
Authors: Peng Xiaoqi , Zhao Hongbo , Ye Lijuan , Hou Fei , Yi Zihan , Ren Yanxin , Lu Lin , Chen Fukun , Lv Juan , Wang Yinghui , Cai Haolin , Zheng Xihua , Yang Qing , Chen Ting
Published: July 2024

Figure S4. WGCNA analysis of the proteomics data.
Supplemental Figure 3 from CDKN2A/B Homozygous Deletion Sensitizes IDH-Mutant Glioma to CDK4/6 Inhibition
Authors: Nasser Ali M. , Melamed Lisa , Wetzel Ethan A. , Chang Jenny Chia-Chen , Nagashima Hiroaki , Kitagawa Yosuke , Muzyka Logan , Wakimoto Hiroaki , Cahill Daniel P. , Miller Julie J.
Published: July 2024

Supplemental Figure 3: Continuous abemaciclib treatment is tolerated appropriately.
Supplementary Table 3 from Cervicovaginal Metabolome and Tumor Characteristics for Endometrial Cancer Detection and Risk Stratification
Authors: Lorentzen Georgia M. , Łaniewski Paweł , Cui Haiyan , Mahnert Nichole D. , Mourad Jamal , Borst Matthew P. , Willmott Lyndsay , Chase Dana M. , Roe Denise J. , Herbst-Kralovetz Melissa M.
Published: July 2024

Statistical analysis of participant demographics in the different groups analysed. Values are n (%) unless stated as mean (SD). P-values were calculated using Kruskal-Wallis test for continuous variables and Fisher’s exact test for categorical variables.
Supplementary Figure S2 from Phase II Study to Determine the Antitumor Activity and Safety of Simlukafusp Alfa (FAP-IL2v) Combined with Atezolizumab in Esophageal Cancer
Authors: Prenen Hans , Deva Sanjeev , Keam Bhumsuk , Lindsay Colin R. , Lugowska Iwona , Yang James C. , Longo Federico , de Miguel Maria , Ponz-Sarvise Mariano , Ahn Myung-Ju , Gumus Mahmut , Champiat Stephane , Italiano Antoine , Salas Sébastien , Perets Ruth , Arslan Cagatay , Cho Byoung C. , Evers Stefan , Boetsch Christophe , Marbach Daniel , Dejardin David , Sleiman Nassim , Ardeshir Caroline , Richard Muriel , Charo Jehad , Kraxner Anton , Keshelava Nino , Teichgräber Volker , Moreno Victor
Published: July 2024

Biomarker analyses and association with clinical outcomes
Supplementary Table S3 from Antibody–Drug Conjugate Sacituzumab Govitecan Enables a Sequential TOP1/PARP Inhibitor Therapy Strategy in Patients with Breast Cancer
Authors: Bardia Aditya , Sun Sheng , Thimmiah Nayana , Coates James T. , Wu Bogang , Abelman Rachel O. , Spring Laura , Moy Beverly , Ryan Phoebe , Melkonyan Mark N. , Partridge Ann , Juric Dejan , Peppercorn Jeffrey , Parsons Heather , Wander Seth A. , Attaya Victoria , Lormil Brenda , Shellock Maria , Nagayama Aiko , Bossuyt Veerle , Isakoff Steven J. , Tolaney Sara M. , Ellisen Leif W.
Published: July 2024

Table S3: Specific Dose-Limiting Toxicities and corresponding patient numbers
Data from Minimal Residual Disease using a Plasma-Only Circulating Tumor DNA Assay to Predict Recurrence of Metastatic Colorectal Cancer Following Curative Intent Treatment
Authors: Parikh Aparna R. , Chee Bryant H. , Tsai Jill , Rich Thereasa A. , Price Kristin S. , Patel Sonia A. , Zhang Li , Ibrahim Faaiz , Esquivel Mikaela , Van Seventer Emily E. , Jarnagin Joy X. , Raymond Victoria M. , Corvera Carlos U. , Hirose Kenzo , Nakakura Eric K. , Corcoran Ryan B. , Van Loon Katherine , Atreya Chloe E.
Published: July 2024

AbstractPurpose:
Minimal residual disease (MRD) detection can identify the recurrence in patients with colorectal cancer (CRC) following definitive treatment. We evaluated a plasma-only MRD assay to predict recurrence and survival in patients with metastatic CRC who underwent curative intent procedures (surgery and/or radiotherapy), with or without (neo)adjuvant chemotherapy. The primary objective of this study was to assess the correlation of postprocedure tumor cell–free DNA detection status with radiographic disease recurrence.
Experimental Design:
Preprocedure and postprocedure longitudinal samples were collected from 53 patients and analyzed with a multiomic MRD assay detecting circulating tumor DNA (ctDNA) from genomic and epigenomic signals. Preprocedure and postprocedure ctDNA detection correlated with recurrence-free and overall survival (OS).
Results:
From 52 patients, 230/233 samples were successfully analyzed. At the time of data cutoff, 36 (69.2%) patients recurred with median follow-up of 31 months. Detectable ctDNA was observed in 19/42 patients (45.2%) with ctDNA analyzed 3 weeks postprocedure. ctDNA detection 3 weeks postprocedure was associated with shorter median recurrence-free survival (RFS; HR, 5.27; 95% CI, 2.31–12.0; P < 0.0001) and OS (HR, 12.83; 95% CI, 3.6–45.9; P < 0.0001). Preprocedure ctDNA detection status was not associated with RFS but was associated with improved OS (HR, 4.65; 95% CI, 1.4–15.2; P = 0.0111). Undetectable ctDNA preprocedure had notable long-term OS, >90% 3 years postprocedure.
Conclusions:
In this cohort of oligometastatic CRC, detection of ctDNA preprocedure or postprocedure was associated with inferior outcomes even after accounting for known prognostic clinicopathologic variables. This suggests ctDNA may enhance current risk stratification methods helping the evaluation of novel treatments and surveillance strategies toward improving patient outcomes.
Supplementary Table 3 from Tumor-Immune Signatures of Treatment Resistance to Brentuximab Vedotin with Ipilimumab and/or Nivolumab in Hodgkin Lymphoma
Authors: Gonzalez-Kozlova Edgar , Huang Hsin-Hui , Jagede Opeyemi A. , Tuballes Kevin , Del Valle Diane M. , Kelly Geoffrey , Patel Manishkumar , Xie Hui , Harris Jocelyn , Argueta Kimberly , Nie Kai , Barcessat Vanessa , Moravec Radim , Altreuter Jennifer , Duose Dzifa Y. , Kahl Brad S. , Ansell Stephen M. , Yu Joyce , Cerami Ethan , Lindsay James R. , Wistuba Ignacio I. , Kim-Schulze Seunghee , Diefenbach Catherine S. , Gnjatic Sacha
Published: July 2024

OS Multivariate analysis showing that markers significant during univariate analysis are not significant during multivariate analysis.
Supplementary Table 1 from Tumor-Immune Signatures of Treatment Resistance to Brentuximab Vedotin with Ipilimumab and/or Nivolumab in Hodgkin Lymphoma
Authors: Gonzalez-Kozlova Edgar , Huang Hsin-Hui , Jagede Opeyemi A. , Tuballes Kevin , Del Valle Diane M. , Kelly Geoffrey , Patel Manishkumar , Xie Hui , Harris Jocelyn , Argueta Kimberly , Nie Kai , Barcessat Vanessa , Moravec Radim , Altreuter Jennifer , Duose Dzifa Y. , Kahl Brad S. , Ansell Stephen M. , Yu Joyce , Cerami Ethan , Lindsay James R. , Wistuba Ignacio I. , Kim-Schulze Seunghee , Diefenbach Catherine S. , Gnjatic Sacha
Published: July 2024

CyTOF antibody panel details.
Mobile forensics tools and techniques for digital crime investigation: a comprehensive review
Authors: Sutikno Tole
Published: July 2024

Extracting and analyzing data from smartphones, IoT devices, and drones is crucial for conducting digital crime investigations. Effective cyberattack mitigation necessitates the use of advanced Android mobile forensics techniques. The investigation necessitates proficiency in manual, logical, hex dump, chip-off, and microread methodologies. This paper provides a comprehensive overview of Android mobile forensics tools and techniques for digital crime investigation, as well as their use in gathering and analyzing evidence. Forensic software tools like Cellebrite UFED, Oxygen Forensic Detective, XRY by MSAB, Magnet AXIOM, SPF Pro by SalvationDATA, MOBILedit Forensic Express, and EnCase Forensic employ both physical and logical techniques to retrieve data from mobile devices. These advanced tools offer a structured approach to tackling digital crimes effectively. We compare dependability, speed, compatibility, data recovery accuracy, and reporting. Mobile-network forensics ensures data acquisition, decryption, and analysis success. Conclusions show that Android mobile forensics tools for digital crime investigations are diverse and have different capabilities. Mobile forensics software offers complete solutions, but new data storage and encryption methods require constant development. The continuous evolution of forensic software tools and a comprehensive tool classification system could further enhance digital crime investigation capabilities.
Reconfigurable data intensive service for low latency cyber-physical systems and IoT communication
Authors: Gupta Prince , Sharma Rajeev , Gupta Sachi
Published: July 2024

The fourth industrial revolution is realized through the many developments in cyber-physical systems (CPS) made possible by the widespread use of the internet of things (IoT). CPS sensor networks must enable mobile and wireless CPSs with their specific flexibility and heterogeneity needs without compromising quality of service (QoS). The research article focuses on reconfigurable data communication hardware for numerous IoT-supporting infrastructures and performance estimation using delay, power, throughput, and packet delivery ratio (PDR) for different IoT node configurations. Tree topology-based network configuration from cloud data to sensor fog organizers, sensor network directors, and IoT-embedded sensors is supported. Functional simulation is performed in iFoGSim, Xilinx ISE, and Modelsim 10.0 with a maximum of 64 variable nodes programmed for data communication and interplay verification with a minimum delay of 9.1 ns, maximum frequency of 319 MHz, power of 7.5 mW, throughput of 0.280, and maximum PDR=1. The simulation is applicable for fog computing and CPS processed from different alters in specific topologies.
Optimized Kalman filtering in dynamical environments for thumb robot motion estimation
Authors: Herlambang Teguh , Susanto Fajar Annas , Firdaus Aji Akbar , Kusuma Vicky Andria , Suprapto Sena Sukmananda , Muhaimin Muhaimin , Arof Hamzah
Published: July 2024

Stroke, a prevalent nerve disorder in Indonesia, necessitates post-stroke rehabilitation like physical and occupational therapy. Hand and finger muscle training, crucial for restoring movement, often involves innovative solutions like finger prosthetic robotics arms. In particular, the advancement in thumb robotics emphasizes the estimation of thumb motion, where the ensemble Kalman filter square root (EnKF-SR) and H-infinity methods are deemed dependable for both linear and nonlinear models. Simulation results, using 400 ensembles, demonstrated nearly identical accuracy between the methods, exceeding 99%, with a 6-7% increase in accuracy compared to 200 ensembles. These advancements offer promising prospects for effective post-stroke rehabilitation and improved thumb movement restoration.
Improved automated parallel implementation of GMM background subtraction on a multicore digital signal processor
Authors: Bariko Smail , Klilou Abdessamad , Abounada Abdelouahed , Arsalane Assia
Published: July 2024

Scene segmentation is an essential step in a wide range of video processing applications, for instance, object recognition and tracking. The Gaussian mixture model (GMM) for background subtraction (BS) has gained widespread usage in scene segmentation, despite its known computational intensity. To tackle this challenge, we propose a practical solution to accelerate processing through a parallel implementation on an embedded multicore platform. In this paper, we present an improved automated parallel implementation of the GMM algorithm using the Orphan directive provided by open multiprocessing (OpenMP). Experimental assessments conducted on the eight cores of the C6678 digital signal processor (DSP) demonstrate significant advancements in parallel efficiency, particularly when handling high-resolution frames, including high-definition (HD) and full-HD resolutions. The achieved parallel efficiency surpasses the results obtained with classical OpenMP scheduling modes, encompassing dynamic, static, and guided approaches. Specifically, the parallel efficiency reaches approximately 82% for full-HD resolution frames and, 99.3% for low-resolution frames, respectively.