bluuebunny/crossref_metadata_2025 huggingface dataset:
Classification of Non-Civil Servant Performance Appraisal Using Naïve Bayes Classifier Algorithm
Authors: Dewi Sofia
Published: September 2023

Employee performance assessment is a way to measure the level of employee productivity. In the process of assessing the performance of Non-Civil Servants (non-PNS) employees at the Regional Technical Implementation Unit of Education and Training of Cooperatives and Entrepreneurs (UPTD P3W) at this time, it is required to classify data based on several factors to find out whether the employee fits into the eligible category or not as the best employee to become a civil servant (PNS) candidate. The purpose of this research is to make it easier to determine the classification of the performance assessment of non-PNS employees at UPTD P3W using the Naïve Bayes Classifier Algorithm and to determine the level of accuracy in the classification of the performance assessment. In this study, the authors used 498 data as training data and 105 data as testing data for manual testing in Excel and for testing using RapidMiner tools. Based on the analysis in the study, the result of the predictions determines the best employees to become candidates for civil servants quickly and accurately, while from the tests performed by comparing training data and with data testing using RapidMiner tools, the accuracy rate is 84.76%.
КОРХОНАЛАРНИНГ ЛИКВИДЛИЛИГИНИ ТАЪМИНЛАШНИНГ МАКРОИҚТИСОДИЙ ОМИЛЛАРИ
Authors: Бауетдинов Мажит
Published: September 2023

Корхоналарнинг ликвидлилиги макроиқтисодий сиёсатнинг ўзгаришига бевосита боғлиқ. Жумладан, миллий валютанинг девальвация суръатини ва инфляция даражасини ошиши корхоналарнинг ликвидлилигига салбий таъсир қилади. Мақолада республикамиз корхоналарининг ликвидлилига таъсир қилувчи макроиқтисодий омилларнинг салбий таъсирига барҳам бериш йўллари асослаб берилган.
СОЛИҚ ИЖРОСИНИ ТАЪМИНЛАШ БЎЙИЧА ҚОНУНЧИЛИК БАЗАСИ: АСОСИЙ ТАРКИБИЙ ҚИСМЛАР
Authors: Очилов Адҳам
Published: September 2023

Мақолада Ўзбекистон солиқ қонунчилигининг меъёрий-ҳуқуқий базаси ўрганилди, асосий эътибор солиқ қонунчилиги, солиқ тўловчиларнинг мажбуриятлари ва солиқ маъмуриятчилиги органларининг ролига қаратилган. Ўзбекистон Солиқ кодекси солиққа тортишнинг асоси сифатида муҳокама қилиниб, солиқ тўловчиларнинг ҳуқуқлари ва мажбуриятлари ўрганилган. Шунингдек, у умумий муаммолар, жумладан, солиқ тўлашдан бўйин товлаш, норасмий иқтисодиёт, мураккаб солиқ қонунчилиги ҳамда солиқ қоидаларини янада аниқроқ ва соддалаштириш зарурлиги бўйича хулосалар шакллантирилган.
ЎЗБЕКИСТОН РЕСПУБЛИКАСИ МИНТАҚАЛАРИДА ХОРИЖИЙ ИНВЕСТИЦИЯЛАРДАН ФОЙДАЛАНИШ САМАРАДОРЛИГИ ТАҲЛИЛИ
Authors: Хатамов Нурбек
Published: September 2023

Ушбу мақолада хорижий инвестицияларни жалб қилишда олиб борилаётган ишлар, Ҳудудларнинг барқарор ривожланиши фақат минтақа иқтисодиётини кучли ва узлуксиз инвестиция ҳамда инновацион рағбатлантириш бўйича шарт-шароитлар тўғрисида тўхталиб ўтилади.
ИМПОРТ ЎРНИНИ БОСУВЧИ САНОАТ СИЁСАТИНИНГ ХАЛҚАРО ТАЖРИБАСИ ВА УНДАН ЎЗБЕКИСТОН ШАРОИТИДА ФОЙДАЛАНИШ ЙЎЛЛАРИ
Authors: Абдувохидов Акмал , Тошбоев Бекзод
Published: September 2023

2022-2026 йилларга мўлжалланган Янги Ўзбекистоннинг Тараққиёт стратегиясида миллий иқтисодиёт барқарорлигини таъминлаш ва ялпи ички маҳсулотда саноат улушини оширишга қаратилган саноат сиёсатини давом эттириб, саноат маҳсулотларини ишлаб чиқариш ҳажмини 1,4 бараварга ошириш, Республиканинг экспорт салоҳиятини ошириш орқали 2026 йилда республика экспорт ҳажмларини 30 миллиард АҚШ долларига етказиш кўзда тутилган. Бундай мақсадларнинг амалга оширилиши ўз навбатида чуқур ва пухта ўйланган саноат сиёсатини амалга оширишни тақозо этади. Мазкур мақолада импорт ўрнини босувчи саноат сиёсатини амалга оширишнинг хориж тажрибаси тадқиқ қилинади.
БЮДЖЕТ ТАШКИЛОТЛАРИНИ МОЛИЯЛАШТИРИШ ВА МАБЛАҒЛАРНИ МАҚСАДЛИ САРФЛАНИШИНИ ТАЪМИНЛОВЧИ ИНСТИТУЦИОНАЛ МЕХАНИЗМЛАР
Authors: Абдурахманов Кахрамон
Published: September 2023

Мақолада бюджет ташкилотларини молиялаштириш ва маблағларни мақсадли сарфланишини таъминловчи институционал механизмлар ўрганилади. Иқтисодчи олимларнинг бюджетга оид тадқиқотлари ўрганилди,шунингдек, бюджет ташкилотлари ўз маблағларини бошқариш ва мақсадли сарфланишини таъминлашдаги муаммолар ва ечимлари кўриб чиқилиб, якунида хулосалар шакллантирилди.
Cavidad ósea de stafne
Authors: Aguayo Olivares Hugo , Quevedo Piña Maira
Published: September 2023

La cavidad ósea de Stafne (COS) se presenta como una imagen radiolúcida bien delimitada localizada generalmente en la región molar mandibular, próxima al ángulo y debajo del canal mandibular. Se describen dos casos de pacientes sexo femenino de 60 y 51 años. En la radiografía panorámica de cada paciente se evidenció la presencia de imagen radiolúcida, inferior al canal mandibular, de límites definidos y bordes corticalizados. En los estudios por tomografía computarizada de haz cónico, se observó en los cortes coronales y axiales, la concavidad bien delimitada, formada a expensas de la tabla ósea lingual, mostrando signos tomográficos compatibles con COS. En los casos presentados su localización, la ausencia de síntomas asociados y las características imagenológicas permitieron concluir que se trata de una COS. El diagnóstico diferencial incluye el quiste óseo traumático, tumores de glándulas salivales, hemangiomas intraóseos, lesiones centrales de células gigantes, lesiones fibroóseas, granulomas eosinofílos, enfermedades metastásicas y fibromas osificantes. Esta entidad no requiere tratamiento y la conducta a seguir es la realización de controles radiográficos periódicos.
Percepciones del autoconcepto en estudiantes de Educación Secundaria Obligatoria a través de la mediación artística
Authors: López-Ruiz David , Bernal-Caballero María
Published: September 2023

The main objective of this Project is to reflect on how the self-concept of students of First year Secondary Education can be developed through artistic mediation. It is a subject that appears transversally in the curriculum but that perhaps it does not get developed enough in the classrooms. To do this, a brief investigation is carried out on the main proposals of experts in the field that support the importance of artistic expression as a way for adolescent to reach a positive integral development. In order to achieve all this, two questionnaires have been developed. One initial before carrying out the activity and another at the end of it. Later a didactic proposal applied in two Secondary Education Centre of the Region of Murcia was designed and executed with a sample of 86 students. This proposal covers the five dimensions of self-concept where students work through artistic practice, which has allowed to know how it has influenced adolescents. The didactic proposal designed to ensure that greater self-confidence of the students are the best results of it.

El presente trabajo tiene como objetivos reflexionar sobre cómo se puede desarrollar el autoconcepto de los estudiantes de primero de Educación Secundaria Obligatoria a través de la mediación artística. Es un tema que aparece transversalmente en el currículo pero que quizás no llega a desarrollarse lo suficiente en las aulas. Para ello, se realiza una breve investigación sobre las principales propuestas de diferentes autores que fundamentan la importancia de la expresión artística como medio para que el adolescente llegue a un desarrollo integral positivo.

Para poder alcanzar todo ello se han desarrollado dos cuestionarios. Uno inicial antes de realizar la actividad y otro al final de esta. Posteriormente se ha diseñado y ejecutado una propuesta didáctica aplicada en dos Centros de Educación Secundaria de la Región de Murcia con una muestra de 86 estudiantes. Dicha propuesta abarca las cinco dimensiones del autoconcepto en donde los estudiantes trabajan a través de la práctica artística lo que ha permitido conocer cómo ha influido en los adolescentes. La propuesta didáctica diseñada asegura que, a mayor autoconfianza del estudiante, mejores son los resultados.
Competir para ser feliz: Juegos deportivos de oposición para el desarrollo emocional
Authors: Cifo- Izquierdo María Isabel , Gea-García Gemma María , Yuste-Lucas Juan Luis
Published: September 2023

The aim of this research was to analyzed the emotional intensity for the competitive and non-competitive practice of opposition sports games according to participants’ gender. 73 university students from the Degree in Physical Activity and Sport Sciences took part in the research. After every sport game, the students assessed the intensity of their emotions experienced through the completion of the GES questionnaire. Generalized estimation equations showed that when competing in opposition sports games, higher emotional intensities were recorded in the three types of emotions. In addition, the boys registered higher scores than the girls. However, the presence or absence of competition did not determine differences between genders. The findings allow us to affirm that competition must be included in opposition games so that the emotional experience is more intense, although opportunities should be given to all students so that they can go through the situation of winner and loser. This study demonstrates the benefit of equal opportunities for women and men in the context of emotional physical coeducation. In order to encourage coeducation, from the teaching side other motor situations should be planned that compensate for the difference in emotional intensity experienced by the girls with respect to the boys.

El objetivo de este estudio fue estudiar las intensidades emocionales suscitadas durante la práctica de juegos deportivos de oposición con presencia y ausencia de competición en función del género. Participaron 73 estudiantes universitarios, los cuales después de cada juego valoraron la intensidad de las emociones experimentadas a través de la cumplimentación del cuestionario GES. Las ecuaciones de estimación generalizadas mostraron que al competir en los juegos deportivos de oposición se registraron intensidades emocionales más altas en los tres tipos de emociones. Además, los chicos registraron puntuaciones más altas que las chicas. Sin embargo, la presencia o ausencia de competición no determinó diferencias entre géneros. Estos hallazgos permiten afirmar que se debe incluir la competición en los juegos de oposición para que la vivencia emocional sea más intensa, aunque se debería dar oportunidades a todos los alumnos para que puedan pasar por la situación de ganador y perdedor. Este estudio aporta evidencias para favorecer la igualdad de oportunidades del género femenino y masculino en el contexto de una coeducación física emocional. Para favorecer la coeducación, desde la acción docente se deben planificar otras situaciones motrices que compensen la diferencia en intensidad emocional que vivencian las chicas con respecto a los chicos.
Analysis the Role of the Internet of Things and Industry 4.0 in Healthcare Supply Chain Using Neutrosophic Sets
Authors: AbdelMouty Ahmed M. , Abdel-Monem Ahmed , Abdel Aal Samah Ibrahim , Ismail Mahmoud M.
Published: September 2023

In today's global economy, the Healthcare supply chain (HCSC) must be aware of a market that is both complicated and ever-changing. The HCSC in Industry 4.0 aims to give patients the medicine they need as quickly and cheaply as possible. The HCSC can improve operations by automating routine tasks and reducing human error by using new technologies like the "Internet of Things" (IoT); so, there is a need to analyze the role of IoT and Industry 4.0 in the Healthcare Supply Chain. This paper aims to analyze the role of IoT and Industry 4.0 in HCSC. Also, this paper proposes a framework using a single-valued neutrosophic set with multi-criteria decision-making (MCDM) to overcome uncertainty and deal with the various criteria and features. This paper used the 18 criteria and nine suppliers as an application in the healthcare supply chain. The results concluded that the proposed framework could handle uncertain data and give more effective results in analyzing the role of IoT and Industry 4.0 in HCSC.
Lagrange Multipliers and Neutrosophic Nonlinear Programming Problems Constrained by Equality Constraints
Authors: Jdid Maissam , Smarandache Florentin
Published: September 2023

Operations research science is defined as the science that is concerned with applying scientific methods to complex problems in managing and directing large systems of people, including resources and tools in various fields, private and governmental work, peace and war, politics, administration, economics, planning and implementation in various domains. It uses scientific methods that take the language of mathematics as a basis for it and uses computer, without which it would not have been possible to achieve numerical solutions to the raised problems, those that need correct solutions, when the solutions abound and the options are multiple, so we need a decision based on correct scientific foundations and takes into account all the circumstances and changes that you can encounter the decision-maker during the course of work, and nothing is left to chance or luck, but rather everything that enters into the account and plays its role in decision-making, and we get that when we use the concepts of neutrosophic science to reformulate what the science of operations research presented in terms of methods and methods to solve many practical problems, so we will present in this research a study aimed at shedding light on the most important methods used to solve nonlinear models, which is the Lagrangian multiplier method for nonlinear models constrained by equality and then reformulated using the concepts of neutrosophic science.
Rank and Analysis Several Solutions of Healthcare Waste to Achieve Cost Effectiveness and Sustainability Using Neutrosophic MCDM Model
Authors: Abdelhafeez Ahmed , Mohamed Hoda K. , Khalil Nariman A.
Published: September 2023

Managing healthcare waste (HCWTT) from healthcare facilities is difficult. It's high up on the list of health concerns. This growth in HCWTT has been especially visible in recent years, as the quantity of medical services available has increased. Because of the potential danger, this garbage poses to people and the planet, it must be properly disposed of. Because of ineffective waste management practices, inadequate financial resources, and a lack of adequate facilities, HCWT administration is especially crucial in developing nations. Reducing HCWT via appropriate treatment is important for the area's financial and environmental health. In order to solve single-valued neutrosophic (SVN) group decision-making issues with missing weight details, this research creates a unique multi-criterion decision-making (MCDM) approach. First, it's important to remember that various decision-makers (DMs) have varying levels of expertise. To get over the problem that the standards cannot compensate for each other, an improved version of ELECTRE is studied. The ELECTRE method is used under neutrosophic environment to rank solutions of HCWT.
AI for All?
Authors: Luchs Inga
Published: September 2023

Research in artificial intelligence (AI) is heavily shaped by big tech today. In the US context, companies such as Google and Microsoft profit from a tremendous position of power due to their control over cloud computing, large data sets and AI talent. In light of this dominance, many media researchers and activists demand open infrastructures and community-led approaches to provide alternative perspectives – however, it is exactly this discourse that companies are appropriating for their expansion strategies. In recent years, big tech has taken up the narrative of democratizing AI by open-sourcing their machine learning (ML) tools, simplifying and automating the application of AI and offering free educational ML resources. The question that remains is how an alternative approach to ML infrastructures – and to the development of ML systems – can still be possible. What are the implications of big tech’s strive for infrastructural expansion under the umbrella of ‘democratization’? And what would a true democratization of ML entail? I will trace these two questions by critically examining, first, the open-source discourse advanced by big tech, as well as, second, the discourse around the AI open-source community Hugging Face that sees AI ethics and democratization at the heart of their endeavour. Lastly, I will show how ML algorithms need to be considered beyond their instrumental notion. It is thus not enough to simply hand over the technology to the community – we need to think about how we can conceptualize a radically different approach to the creation of ML systems.
Un introuvable levier de justice sociale. Démesure militante des circuits courts alimentaires alternatifs
Authors: Montrieux Gabriel
Published: September 2023

Les systèmes de circuits-courts alimentaires alternatifs, incarnés en France par le modèle des Associations pour le maintien d’une agriculture paysanne (AMAP), ont initialement pour objectif d’établir des liens de solidarité entre consommation et production. Ces systèmes alimentaires ont progressivement été investis d’enjeux supplémentaires, particulièrement en matière de justice sociale, en visant à donner accès au plus grand nombre à des produits alimentaires inaccessibles dans les circuits conventionnels de distribution. Pourtant, malgré le travail fourni au sein du mouvement amapien pour atteindre cette ouverture sociale, les catégories intermédiaires et dominantes restent fortement surreprésentées parmi les adhérent·e·s de ces systèmes. Cet article vise à saisir les principes à l’oeuvre dans la faible ouverture sociale des AMAP. Il mobilise des données qualitatives (entretiens biographiques et observations) produites lors d’un travail d’enquête mené entre 2013 et 2019 dans l’agglomération lyonnaise, auprès d’AMAP locales et des réseaux militants qui coordonnent le mouvement amapien. La multiplication des enjeux projetés sur les AMAP génère des contradictions internes, avec lesquelles les responsables des collectifs amapiens composent difficilement. Alors que les AMAP apparaissent désarmées pour mettre en place une plus grande accessibilité économique des circuits-courts, l’ouverture sociale de ces systèmes apparaît susceptible de menacer l’entre-soi social sur lequel les collectifs amapiens se sont localement constitués. La difficulté des AMAP à inclure économiquement, symboliquement et socialement des catégories dominées doit en réalité beaucoup à la manière dont ces catégories sont exclues, en amont, des processus de définition des enjeux opérés par les réseaux militants amapiens et par les collectivités territoriales qui entendent lutter contre la précarité alimentaire.
Actomyosin remodeling regulates biomineral formation, growth and morphology during eukaryote skeletogenesis
Authors: Hijaze Eman , Gildor Tsvia , Seidel Ronald , Layous Majed , Winter Mark , Bertinetti Luca , Politi Yael , de-Leon Smadar Ben-Tabou
Published: September 2023

Biomineralization had apparently evolved independently in different phyla, using distinct minerals, organic scaffolds and gene regulatory networks (GRNs). However, diverse eukaryotes from unicellular organisms, through echinoderms to vertebrates, use the actomyosin network during biomineralization. Specifically, the actomyosin remodeling protein, Rho-associated coiled-coil kinase (ROCK) regulates cell differentiation and gene expression in vertebrates’ biomineralizing cells, yet, little is known on ROCK’s role in invertebrates’ biomineralization. Here we reveal that ROCK controls the formation, growth and morphology of the calcite spicules in the sea urchin larva. ROCK expression is elevated in the sea urchin skeletogenic cells downstream of the Vascular Endothelial Growth Factor (VEGF) signling. ROCK inhibition impairs the organization of F-actin around the spicules, disrupts skeletogenic gene expression and leads to skeletal loss. ROCK inhibition after spicule formation reduces spicule elongation rate and induces ectopic spicule branching. Reduced skeletal growth and enhanced branching are also observed under direct perturbations of the actomyosin network. Similar skeletogenic phenotypes are observed when ROCK is inhibited in a skeletogenic cell culture, indicating that these phenotypes are due to ROCK activity specifically in the skeletogenic cells. We propose that the actomyosin network was employed independently, downstream of distinct GRNs, to regulate biomineral growth and morphology across Eukaryotes.
English teaching system design based on ID3 algorithm and node optimization
Authors: Jiang Wangmeng , Ma Qiang
Published: September 2023

In order to optimize the integration of English multimedia resources and achieve the goal of sharing English teaching resources in education, this article reconstructs the traditional college English curriculum system. It divides professional English into learning modules according to different majors integrating public health teaching resources. How optimize the integration of English multimedia resources and achieving the goal of sharing English teaching resources (ETR) is the main direction of English teaching reform during the current COVID-19 pandemic. An English multimedia teaching resource-sharing platform is designed to extract feature items from multimedia teaching resources using the ID3 information gain method and construct a decision tree for resource push. In resource sharing, a structured peer-to-peer network is used to manage nodes, query location and share multimedia teaching resources. The optimal gateway node is selected by calculating the distance between each gateway node and the fixed node. Finally, a collaborative filtering (CF) algorithm recommends Multimedia ETR to different users. The simulation results show that the platform can improve the sharing speed and utilization rate of teaching resources, with maximum throughput reaching 12 Mb/s and achieve accurate recommendations of ETR.
Application of bubble streams to control biofouling on marine infrastructure—pontoon-scale implementation
Authors: Hopkins Grant A. , Scott Nicholas , Cahill Patrick
Published: September 2023

There is a lack of cost-effective, environmentally-friendly tools available to manage marine biofouling accumulation on static artificial structures such as drilling rigs, wind turbines, marine farms, and port and marina infrastructure. For there to be uptake and refinement of tools, emerging technologies need to be tested and proven at an operational scale. This study aimed to see whether biofouling accumulation could be suppressed on marine infrastructure under real-world conditions through the delivery of continuous bubble streams. Submerged surfaces of a floating marina pontoon were cleaned in-situ by divers, and the subsequent colonisation by biofouling organisms was monitored on treated (bubbles applied) and untreated sections. Continuous bubble streams proved highly effective (>95%) in controlling macrofouling accumulation on the underside surface of the marina pontoon for the first 2 months after deployment, but efficacy dropped off rapidly once bubble stream delivery was partially obscured due to biofouling accumulation on the diffuser itself. Although extensive macrofouling cover by mussels, bryozoans and hydroids was observed on treated surfaces by 4 months (27.5%, SE = 4.8%), biofouling % cover and diversity was significantly higher on untreated surfaces (79.6%, SE = 2.9%). While this study demonstrates that continuous bubble streams greatly restrict biofouling accumulation over short-to-medium timescales, improved system design, especially the incorporation of diffusers resistant to fouling, is needed for the approach to be considered a viable long-term option for biofouling management on static artificial structures.
Blood and Dirt: Prison Labour and the Making of New Zealand
Authors: Davidson Jared
Published: September 2023

Picture, for a minute, every artwork of colonial New Zealand you can think of. Now add a chain gang. Hard-labour men guarded by other men with guns. Men moving heavy metal. Men picking at the earth. Over and over again. This was the reality of nineteenth-century New Zealand. Forced labour haunts the streets we walk today and the spaces we take for granted. The unfree work of prisoners has shaped New Zealand's urban centres and rural landscapes, and Te Moana-nui-a-Kiwa – the Pacific – in profound and unsettling ways. Yet these stories are largely unknown: a hidden history in plain sight. Blood and Dirt explains, for the first time, the making of New Zealand and its Pacific empire through the prism of prison labour. Jared Davidson asks us to look beyond the walls of our nineteenth- and early twentieth-century prisons to see penal practice as playing an active, central role in the creation of modern New Zealand. Journeying from the Hohi mission station in the Bay of Islands through to Milford Sound, vast forest plantations, and on to Parliament itself, this vivid and engaging book will change the way you view New Zealand.
Awareness of Medicolegal Issues among Interns and Resident Doctors at a Tertiary Care Hospital in Kolar, Karnataka, India: A Cross-sectional Study
Authors: Reddy P Srinivasa , Abhinandana R
Published: September 2023

Introduction: Medicolegal issues are handled by every doctor in their day-to-day medical practice. However, if they are not well versed in the rules of managing such cases and the law behind them, they often land into criticism and distress in court while dealing with evidence in Medicolegal Cases (MLCs). Aim: To assess the awareness of interns and resident doctors, who are working at RL Jalappa Hospital and Research Centre, regarding the management of MLCs in their day-to-day practices. Materials and Methods: A cross-sectional questionnairebased study was conducted to determine the awareness of medicolegal issues among 107 participants, including interns and resident doctors in the Department of Forensic Medicine and Toxicology at a tertiary care hospital, Sri Devaraj Urs Medical College, Tamaka Kolar, Karnataka, India, from January 2022 to October 2022. A prevalidated list of 21 questionnaires, obtained through a pilot study with Cronbach’s alpha=0.78, was used. Numerical data were summarised using mean and standard deviation, while categorical data were expressed using percentages. Results: The mean age of the study participants was 28.6 years. Most of the participants were from Surgery and allied fields (61%), and the majority of the participants (51.4%) had one to two years of experience in the medical field. Among the findings, it was observed that 67.28% of participants had insufficient knowledge about the minimum age requirement for informed consent, 60% of residents had insufficient knowledge of maintaining meticulous medical records, 57% of the participants responded incorrectly regarding the desired way of handling brought dead cases in hospitals, and 63.8% of the participants had poor knowledge of the Karnataka Private Medical Establishment (KPME) act and organ transplantation act. Conclusion: The study concluded that while interns and postgraduates showed some level of awareness regarding certain aspects of medicolegal issues, like need for consent, they still lack comprehensive knowledge on subjects like legal requirements of consent, medical records, the KPME act, and organ transplantation act. Therefore, it is necessary to modify the curriculum for students and provide orientation programs, continued medical education, and guest lectures to interns and residents to build fiduciary character in Indian medical graduates.
Growth Performance in Sangkuriang Catfish (Clarias gariepinus Var. Sangkuriang) and Transgenic Mutiara Catfish (Clarias gariepinus) using Low Protein Feed
Authors: Buwono Ibnu D. , A. H. S. Asep , Iskandar  , I. Azahra
Published: September 2023

This research was conducted at the hatchery building 4, Faculty of Fisheries and Marine Sciences, Universitas Padjadjaran. The implementation starts from November to December 2022. This experiment aims to test the growth performance of the G5 transgenic mutiara catfish by providing low protein feed. The treatment design used the completely randomized design method with four treatments (A:39% feed protein; B:31% feed protein; C:14% feed protein for transgenic catfish and D:39% feed protein for non transgenic fish as comparison) with three replications. Data were analyzed using Sigmaplot 15.0 for test parameters absolute weight gain (Wg), feed conversion ratio (FCR), protein efficiency ratio (PER), and protein retention (PR) and using the Duncan Multiple Range Test (DMRT) at a 95% confidence level. The best treatment results for feed efficiency and protein efficiency were obtained in treatments A and B with values ​​of 1.25 and 1.43 as well as 2.04 and 2.23. Transgenic mutiara catfish can grow on a low protein diet is a new finding from this study.
Assessment of Shelf Life of Chicken Eggs Enriched Wheat Flour Based Noodles
Authors: Bhumre Prabhawati N. , Londhe Sanjaykumar V. , Patil Dipali P. , Rindhe Sandeep N. , Waghmare Rupesh N.
Published: September 2023

The goal of the current study was to create noodles that contained varying percentages of chicken eggs (0%, 10%, 20%, and 30%) With distilled water, the fresh eggs were washed and cleaned.In the department of Livestock Products Technology, eggs are cracked into a glass jar, mixed with salt, water, and wheat flour at the right ratio, and prepared dough that is then used to formulate products. All of the product's sensory evaluations decreased with increasing storage time at room temperature (35° C). Contrarily, the pH, TBA number, tyrosine value, and total plate counts increased significantly with increased storage but remained under the spoiling limit for the first 40 days of storage. However, moisture, fat, and protein decreased with increased storage. Coliform counts were not discovered in every sample over the course of storage. Up to the tenth day of storage, there were no indications of yeast or mould counts. They did, however, start to show up starting on day 20 and increased significantly (P 0.05) across all treatments.
Utilization of Nanobodies in Immunoturbidimetric Assays
Authors: Peng Yue Lei , Han Hao Jie , Du Bing Bing , Zeng Run Ying , Yang Xin
Published: September 2023

Aims: Nanobodies, characterized by their small size, accessibility, and high yield, are emerging as advantageous tools in various applications.  Despite these benefits, their integration into the formulation of immunoturbidimetric reagents has remained limited since their discovery.

Methodology: This study utilized nanobodies specific to cystatin C to formulate immunoturbidimetric reagents and compared them with traditional rabbit polyclonal antibody reagents. 

Results: The findings revealed that the multiantibody affinity of Cys-rPAB surpasses that of Cys-VHH-104 and Cys-VHH-704 nanobodies, although the difference is not statistically significant. Upon evaluating the reagent formulation performance, both types of antibodies were found to satisfy the prerequisites of conventional immunoturbidimetric assay reagents.  The correlation coefficient R2 in the statistical analysis of the clinical results was 0.9986, signifying a high degree of consistency.

Conclusion: These findings underscore the feasibility and considerable economic potential of employing nanobodies in immunoturbidimetric reagents.
Belimumab Treatment for Lupus Nephritis: A Narrative Review
Authors: Mohamoud Iman , Ismail Nabeelah , Haque Neusha , Sarwar Sarosh , Afsharghasemi Yasaman , Demyati Ali , Ismail Faraaz , Alkowatli Mohammad , Okoye Chiugo , Singh Purnima
Published: September 2023

Background: Lupus nephritis (LN) is a common complication in Systemic lupus erythematosus (SLE) patients. Treatment of lupus nephritis ranges from initial management with lifestyle changes and medications like corticosteroids for mild cases to the most intensive approach involving high-dose immunosuppressive therapy and potentially kidney transplantation for severe cases. A monoclonal antibody, called belimumab, that targets the B-lymphocyte stimulator (BLyS) has shown promise as a treatment for LN. This narrative review endeavors to provide a comprehensive overview of how belimumab functions, its efficacy, and its safety considerations when utilized in the treatment of lupus nephritis.

Methodology: A literature review was conducted on various databases, including PubMed, Medline, Science Direct, and Google Scholar, using the following terms: “lupus nephritis”, “safety”, “efficacy” and “belimumab”. All articles considered relevant were included. No limitations were imposed on the publication date.

Results: Improvements in clinical response and a decrease in glucocorticoid dosage were observed in patients with lupus nephritis treated with belimumab, according to our narrative review. Additionally, significantly higher rates of renal response were proven with the combination of belimumab and standard therapy. Trials showed similar safety profiles for belimumab added to standard therapy versus standard therapy alone.

Conclusion: By focusing on B-cell dysregulation and lowering autoimmune response, belimumab provides a promising treatment approach for lupus nephritis. Its potential as an additional treatment for LN is supported by its effectiveness in enhancing renal responsiveness and overall disease activity as well as by its positive safety profile.
STUDI PERSEPTUAL KEDAI KOPI COFFEE-TO-GO DI SURABAYA MENGGUNAKAN PERSPEKTIF CUSTOMER-BASED BRAND EQUITY
Authors: Verdianto Herodion , Jaolis Ferry
Published: September 2023

Fenomena makin banyaknya kemunculan pelaku bisnis kedai kopi telah membawa era baru pada industri ini. Di era ini kedai kopi banyak muncul brand kedai kopi dengan konsep Coffee-to-go dimana setiap orang dapat membeli dan membawa kopi ini kemana saja untuk dinikmati. Dengan banyaknya pemain di industri ini akan sulit untuk bersaing dan bertahan di pasar. Melalui penelitian diharapkan dapat memahami atribut apa yang diasosikan konsumen kepada brand kedai Coffee-to-go dan membantu brand berkomunikasi lebih efektif setelah mengetahui atribut apa yang melekat pada brand. Metode pengolahan data dilakukan dengan cara melakukan pemeriksaan data, klasifikasi data, verifikasi data, analisa, dan juga pemberian rekomendasi. Sedangkan metode analisis data menggunakan analisis konten, analisis kerangka kerja, dan analisis statistik deskriptif yang datanya diperoleh dari hasil kuesioner dan juga wawancara.
Accommodating Religious Objections to Vaccination Mandates—Implications of Groff v DeJoy for Health Care Employers
Authors: Mello Michelle M. , Parmet Wendy E.
Published: September 2023

This JAMA Forum discusses Title VII challenges to vaccination mandates, the Groff v DeJoy decision, and the implications of the decision for health care employers.
Early Access to Testosterone Therapy in Transgender and Gender-Diverse Adults Seeking Masculinization
Authors: Nolan Brendan J. , Zwickl Sav , Locke Peter , Zajac Jeffrey D. , Cheung Ada S.
Published: September 2023

Importance

Testosterone treatment is a necessary component of care for some transgender and gender-diverse individuals. Observational studies have reported associations between commencement of gender-affirming hormone therapy and improvements in gender dysphoria and depression, but there is a lack of data from randomized clinical trials.

Objective

To assess the effect of testosterone therapy compared with no treatment on gender dysphoria, depression, and suicidality in transgender and gender-diverse adults seeking masculinization.

Design, Setting, and Participants

A 3-month open-label randomized clinical trial was conducted at endocrinology outpatient clinics and primary care clinics specializing in transgender and gender-diverse health in Melbourne, Australia, from November 1, 2021, to July 22, 2022. Participants included transgender and gender-diverse adults aged 18 to 70 years seeking initiation of testosterone therapy.

Interventions

Immediate initiation of testosterone commencement (intervention group) or no treatment (standard care waiting list of 3 months before commencement). This design ensured no individuals would be waiting longer than the time to standard care.

Main Outcomes and Measures

The primary outcome was gender dysphoria, as measured by the Gender Preoccupation and Stability Questionnaire. Secondary outcomes included the Patient Health Questionnaire-9 (PHQ-9) to assess depression and the Suicidal Ideation Attributes Scale (SIDAS) to assess suicidality. Questionnaires were undertaken at 0 and 3 months. The evaluable cohort was analyzed.

Results

Sixty-four transgender and gender-diverse adults (median [IQR] age, 22.5 [20-27] years) were randomized. Compared with standard care, the intervention group had a decrease in gender dysphoria (mean difference, −7.2 points; 95% CI, −8.3 to −6.1 points; P < .001), a clinically significant decrease in depression (ie, change in score of 5 points on PHQ-9; mean difference, −5.6 points; 95% CI, −6.8 to −4.4 points; P < .001), and a significant decrease in suicidality (mean difference in SIDAS score, −6.5 points; 95% CI, −8.2 to −4.8 points; P < .001). Resolution of suicidality assessed by PHQ-9 item 9 occurred in 11 individuals (52%) with immediate testosterone commencement compared with 1 (5%) receiving standard care (P = .002). Seven individuals reported injection site pain/discomfort and 1 individual reported a transient headache 24 hours following intramuscular administration of testosterone undecanoate. No individual developed polycythemia.

Conclusions and Relevance

In this open-label randomized clinical trial of testosterone therapy in transgender and gender-diverse adults, immediate testosterone compared with no treatment significantly reduced gender dysphoria, depression, and suicidality in transgender and gender-diverse individuals desiring testosterone therapy.

Trial Registration

ANZCTR Identifier: ACTRN1262100016864
Personalized Scrub Caps for Identification of Surgical Trainees
Authors: Agarwal Divyansh , Bharani Tina , Mullen John T.
Published: September 2023

This survey study investigates whether personalized scrub caps for surgical trainees can help decrease role and name misidentification, microaggressions, and miscommunication-related delays in patient care.
Impact of decorative pictures in learning materials: The effect of attention‐grabbing features
Authors: Morita Aiko , Fukuya Izumi
Published: September 2023

Decorative pictures have been shown to be detrimental to multimedia learning. This study aims to determine whether a decorative picture is detrimental only when it is attention‐grabbing. In Experiment 1, we presented the participants with learning materials containing a decorative picture and asked them to rate the extent to which the picture was attention‐grabbing. We systematically manipulated the elements of decorative pictures and identified position, size, and color as attention‐grabbing factors. Based on these findings, we developed learning materials that included more or less attention‐grabbing decorative pictures. Experiment 2 revealed that texts with more attention‐grabbing decorative pictures were fixated on for shorter periods than those without pictures. However, Experiment 3 demonstrated that the attention‐grabbing decorative pictures did not hinder learning. These results suggest that while decorative pictures can attract attention, they do not impede learning. Considering their positive effect on motivation, incorporating attention‐grabbing decorative pictures into learning materials would enhance learning.
Spatiotemporally Controllable Chemical Delivery Utilizing Electroosmotic Flow Generated in Combination of Anionic and Cationic Hydrogels
Authors: Terutsuki Daigo , Miyazawa Sho , Takagi Junya , Yamada Akihiro , Sun Yunhao , Abe Hiroya , Wang Gaobo , Nishizawa Matsuhiko
Published: September 2023

Spatiotemporally controlled chemical delivery is crucial for various biomedical engineering applications. Here, a novel concept of electrically controllable delivery utilizing electroosmotic flow (EOF) generated in a combination of anionic and cationic hydrogels (A‐ and C‐hydrogels) is reported. The unique advantages of the A/C‐hydrogel combination are demonstrated utilizing a flexible sheet‐shaped and a thin tubular devices. Since the directions of EOF in the A‐ and C‐hydrogels are opposite to each other, the ionic current for EOF generation flows inside the delivery devices, enabling chemical delivery without accompanying external ionic current that could stimulate target cells and tissues. A thin tubular device, which can be inserted into narrow in vivo structures and be integrated with other flexible devices, exhibits high robustness and repeatability thanks to the flexibility and water retentivity of hydrogels. The EOF devices with A/C‐hydrogels combination show high controllability superior to the pumping with a conventional syringe; the volumetric flow rate is able to be controlled proportionally to the current applied, for example, ≈0.4 µL (mA min)−1 for the tubular device. The developed EOF‐based devices are versatile for delivery of most chemicals regardless of their charge and size, and have great potential for both biomedical researches and therapeutics.
Dual‐Microcavity Technology for Red, Green, and Blue Electroluminescent Devices
Authors: Kim Jun Yong , Lee Sang Youn , Cho Kwan Hyun , Do Yun Seon
Published: September 2023

Microcavity structures are used in inorganic‐, organic‐, quantum‐dot‐, and perovskite‐based electroluminescent (EL) devices to advance next‐generation displays. However, there are difficulties in controlling electrical characteristics and patterning processes for producing different thicknesses for each red, green, and blue (RGB) subpixel, and the issues are more challenging in the high‐resolution display for future realistic media. Here, a novel design method is presented for a dual‐microcavity structure that controls high‐order modes of a second cavity stacked on top of EL devices with the same cavity length for each subpixel to produce multiple peaks at RGB resonant wavelengths. The dual‐microcavity effect demonstrated by top‐emitting organic light‐emitting diodes (OLEDs) can be conveniently fabricated via in situ deposition. By modulating the high‐order modes, the spectral characteristics of each RGB dual‐microcavity top‐emitting OLED (DMTOLED) are manipulated while its electrical properties are maintained. Green DMTOLED exhibits a maximum luminance of 2.075  ×  105 cd m−2, allowing applications not only for commercialized displays but also for outdoor augmented reality and automotive displays. Furthermore, dual‐microcavity structures with narrow spectral bandwidths can be applied to next‐generation EL devices for more realistic media. The method is expected to be applied industrially, promoting the advancement of EL devices for next‐generation displays.
Heterojunction‐Accelerating Lithium Salt Dissociation in Polymer Solid Electrolytes
Authors: Kang Junbao , Deng Nanping , Shi Dongjie , Feng Yang , Wang Ziye , Gao Lu , Song Yunxuan , Zhao Yixia , Cheng Bowen , Li Geng , Kang Weimin , Zhang Kai
Published: September 2023

The practical application of solid‐state lithium‐metal batteries (SSLMBs) based on polymer solid electrolytes has been hampered by their low ion conductivity and lithium‐dendrite‐induced short circuits. This study innovatively introduces 1D ferroelectric ceramic‐based Bi4Ti3O12‐BiOBr heterojunction nanofibers (BIT‐BOB HNFs) into poly(ethylene oxide) (PEO) matrix, constructing lithium‐ion conduction highways with “dissociators” and “accelerating regions.” BIT‐BOB HNFs, as 1D ceramic fillers, not only can construct long‐range organic/inorganic interfaces as ion transport pathways, but also install “dissociators” and “accelerating regions” for these pathways through the electric dipole layer and built‐in electric field of BIT‐BOB HNFs, promoting the dissociation of lithium salts and the transfer of lithium ions. The working mechanisms of BIT‐BOB HNFs in the polymer matrix are verified by experimental tests and density functional theory calculations. The obtained composite solid electrolytes exhibit excellent lithium‐ion conductivity and migration number (6.67 × 10−4 S cm−1 and 0.54 at 50 °C, respectively). The assembled lithium symmetric battery achieves good cycling stability of over 4500 h. The LiFePO4||Li full battery delivers a high Coulombic efficiency (>99.9%) and discharge capacity retention rate (>87%) after 2200 cycles. In addition, the prepared composite polymer solid electrolyte demonstrates good practical application potential in flexible pouch batteries.
Water‐Insensitive Self‐Healing Materials: From Network Structure Design to Advanced Soft Electronics
Authors: Yao Hai , Liu Tong , Jia YongQiang , Du YingJie , Yao BoWen , Xu JianHua , Fu JiaJun
Published: September 2023

Polymeric materials capable of spontaneously healing physical damages and restoring various functions have been attracting growing interest. Among these, the category of water‐insensitive self‐healing materials emerges as a promising research focus due to their reliable self‐healing and stable mechanical properties in high‐humidity environments and even underwater. In this review, an update on the significant advancements in the design of water‐insensitive self‐healing polymers is presented, which are based on various unique chains. Their advantages and limitations are discussed. Additionally, a series of typical dynamic interactions that are used to enable autonomous self‐healing in underwater environments is highlighted. Moving beyond these fundamental designs, the diverse opportunities to leverage recent synthetic advancements in water‐insensitive self‐healing materials for the progression of soft electronic applications are systematically discussed. Ultimately, the significant challenges and remaining opportunities to present a comprehensive view of the future development of water‐insensitive self‐healing materials are highlighted. This review aims to stimulate further innovation in this burgeoning and emerging field of intrinsic healable materials, interfacing with dynamic chemistry and soft electronics.
Robust Ultrahigh‐Q Quasi‐Bound States in the Continuum in Metasurfaces Enabled by Lattice Hybridization
Authors: Luo Xiaoqing , Han Yingying , Du Xiang , Chen Shuai , Li Guangyuan
Published: September 2023

Bound states in the continuum (BICs) have been of growing interest in photonics for their infinite quality factors and strong field localization. The last decade has witnessed great progress on the highest achievable quality factors of quasi‐BICs. However, it remains challenging to realize robust high‐Q quasi‐BICs that are tolerant to the parameter perturbation. Here, it is demonstrated that silicon metasurfaces formed by the hybridization of two lattices can support robust quasi‐BICs with the highest measured quality factor reaching 4130 and the minimum one larger than 1024, even when the relative displacement varies over the whole range of all the possible values. Taking advantage of the two in‐plane mirror‐symmetry points, for the first time, the transition between a toroidal dipole BIC and an electric quadrupole BIC, which guarantees robust ultrahigh‐Q quasi‐BICs at Γ point, is reported. The minimum quality factors of quasi‐BICs can be further improved significantly by shrinking the meta‐atom size and are immune from the intrinsic absorption loss of silicon in the visible regime. It is envisioned that this study will pave the way for achieving robust ultrahigh‐Q metasurfaces and boost their applications in lasing, nonlinear optics, and biosensing.