bluuebunny/crossref_metadata_2025 huggingface dataset:
Green pathway for the Construction of Aryl-1,8-Naphthyridine-Thiazole Scaffolds And In Vitro-Antimicrobial Evaluation, DNA-Binding Interactions, Viscosity Measurements, Molecular modeling Studies And ADME Properties
Authors: Sonyanaik Banoth , Ravi Dharavath , kishore Kamal , Shyam Perugu , Sakram Boda
Published: August 2023

Environmentally friendly research can be bringing cost-effective technology it is essential and desirable in the current state-of-the-art research. Eco-friendly green synthesis of substituted aryl-1,8-naphthyridine-thiazole-4-carboxamide derivatives and evaluation of their biological studies antibacterial and antifungal activity of all the synthesized compounds demonstrated remarkable in-vitro microbial activity as well as DNA binding studies Viscosity Measurements by electronic absorption spectroscopy. The intrinsic binding constants (Kb) values of (5a-f) molecules with Ct-DNA obtained from UV-Vis spectroscopy. Molecular docking studies results and ADME properties were well complemented to the DNA-binding intercalative studies.
Randomized controlled phase III trial to investigate superiority of robot-assisted gastrectomy over laparoscopic gastrectomy for clinical stage T1-4aN0-3 gastric cancer patients (JCOG1907, MONA LISA study): A study protocol
Authors: Rie Makuuchi , Terashima Masanori , Terada Mitusmi , Mizusawa Junki , Kita Ryosuke , Tokunaga Masanori , Omori Takeshi , Ojima Toshiyasu , Ehara Kazuhisa , Watanabe Masaya , Yanagimoto Yoshitomo , Nunobe Souya , Kinoshita Takahiro , Ito Seiji , Nishida Yasunori , Hihara Jun , Boku Narikazu , Kurokawa Yukinori , Ypshikawa Takaki
Published: August 2023

Background
Laparoscopic gastrectomy (LG) is considered a standard treatment for clinical stage I gastric cancer. Nevertheless, LG has some drawbacks, such as motion restriction and difficulties in spatial perception. Robot-assisted gastrectomy (RG) overcomes these drawbacks by using articulated forceps, tremor-filtering capability, and high-resolution three-dimensional imaging, and it is expected to enable more precise and safer procedures than LG for gastric cancer. However, robust evidence based on a large-scale randomized study is lacking.
Methods
We are performing a randomized controlled phase III study to investigate the superiority of RG over LG for clinical T1-2N0-2 gastric cancer in terms of safety. In total, 1,040 patients are planned to be enrolled from 46 Japanese institutions over 5 years. The primary endpoint is the incidence of postoperative intra-abdominal infectious complications, including anastomotic leakage, pancreatic fistula, and intra-abdominal abscess of Clavien–Dindo (CD) grade ≥ II. The secondary endpoints are the incidence of all CD grade ≥ II and ≥ IIIA postoperative complications, the incidence of CD grade ≥ IIIA postoperative intra-abdominal infectious complications, relapse-free survival, overall survival, the proportion of RG completion, the proportion of LG completion, the proportion of conversion to open surgery, the proportion of operation-related death, and short-term surgical outcomes. The Japan Clinical Oncology Group Protocol Review Committee approved this study protocol in January 2020. Approval from the institutional review board was obtained before starting patient enrollment in each institution. Patient enrollment began in March 2020. We revised the protocol to expand the eligibility criteria to T1-4aN0-3 in July 2022 based on the results of randomized trials of LG demonstrating non-inferiority of LG to open surgery for survival outcomes in advanced gastric cancer.
Discussion
This is the first multicenter randomized controlled trial to confirm the superiority of RG over LG in terms of safety. This study will demonstrate whether RG is superior for gastric cancer.
Trial registration:
The protocol of JCOG1907 was registered in the UMIN Clinical Trials Registry as UMIN000039825 (http://www.umin.ac.jp/ctr/index.htm). Date of Registration: March 16, 2020. Date of First Participant Enrollment: April 1, 2020.
Mechanisms of Silk-Derived Protein (SDP) Hydrolysate Stability within Aqueous Formulation and In Vitro Assessment of NF-kB Inflammatory Pathway Inhibition
Authors: Lawrence Brian D. , Infanger David W.
Published: August 2023

Background
Silk fibroin is a structural protein that can be regenerated into aqueous solution, and then used for a variety of biomedical and advanced material applications due to its high biocompatibility and controllable material properties. Conversely, fibroin solution can have limited utility due to its inherent physical instability to self-associate into higher order structures. Here we describe a fibroin hydrolysate, termed silk-derived protein (SDP), which mimics the same manufacturing process as aqueous silk fibroin but introduces an additional hydrolysis step.
Methods
The biochemical properties and material stability mechanisms of SDP were characterized through various assessments, including MWD, amino acid content, solubility measurements, surface interaction, and protein secondary structure formation. Additional in vitro studies were undertaken to assess SDP’s ability to inhibit NF-kB-mediated inflammation and mRNA transcription.
Results
SDP was found to have enhanced solubility, stability, and surface wetting properties when added to aqueous formulation reaching over 40% wt./vol. concentration and a viscosity of 140 mPa. Mechanistic stability studies indicate that the combination of heating, pressure and LiBr is required to enhance hydrolysate stability by abolishing fibroin’s ability to self-associate through the formation of β-sheet secondary structures. In vitro assays using the HCLE cell lines indicated SDP had dose dependent potency for inhibiting translocation of the p65 transcription factor into the nucleus with, while showing multi-fold reduction in NF-kB driven TNF-α and MMP-9 gene expression.
Conclusions
Collectively, the results support SDP’s use as an anti-inflammatory wetting agent compatible with a wide range of both biomedical and industrial applications, and offers a sustainable biomaterial alternative to existing anti-inflammatories, surfactants, and demulcents that possess higher toxicity profiles.
Guideline to Guidelines. Implementation of scientific evidence into clinical guidelines
Authors: Koller Akos , Takács Johanna
Published: August 2023

Background: The knowledge and help provided by the medical guidelines are essential to make informed clinical decisions. However, there are no systematic methods to assess the efficacy of guidelines, i.e., how much contribution they provide to informed decisions in various health conditions.
Methods: A mathematical analysis was developed to assess the efficacy of guidelines. As an example, the “2020 ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease” (GL-SCE) was analysed/assessed. The analysis was conducted on the Classes of Recommendations (CLASS) and the Levels of Evidence (LEVEL). LEVEL areas under CLASS were calculated to form a Certainty Index (CI:–1 to+1).
Results: The frequency of CLASS I (‘to do’) and CLASS III (‘not to do’) was relatively high in GL-SCE. Yet, the most frequent LEVEL was C, indicating a low quality of scientific evidence. The GL-SCE showed a relatively high CI (+0.57), 78.4% Certainty and 21.6% Uncertainty.
Conclusions: GL-SCE provides a substantial help to decision-making through the recommendations, but the supporting evidence in most CLASS-es has low quality, which is well-reflected in the developed Certainty Index identifying issues that should be clarified and investigated in future studies. We propose that the developed mathematical analysis should be used as a Guideline to Guidelines to assess their efficacy and support their implementation in clinical practice thus providing a ‘quality control’.
Modeling the dynamics of social preparedness with regional interactions to explore efficient flood early warning systems
Authors: Kotani Hitomu , Ogawa Wataru , Matsushima Kakuya , Susaki Junichi , Sawada Yohei
Published: August 2023

Flood early warning systems (FEWS) play a crucial role in mitigating flood damage. To optimize their effectiveness, it is important to understand how people respond to warnings and prepare for flooding events. The key factors influencing social preparedness include (1) direct and (2) indirect experiences of floods and (3) trust in warnings. However, existing socio-hydrological models do not incorporate all these elements. To include these elements for social preparedness, we propose a stylized model that allows multiple regions to influence one another (i.e., regional interactions). We investigate the dynamics of social preparedness in a society composed of regions with varying infrastructure levels (e.g., levee heights) and explore strategies for developing a socially efficient FEWS. Numerical analyses reveal that in a society that has a region characterized by a low infrastructure level (i.e., a region with frequent floods), regional interactions lead to a pronounced cry wolf effect due to false alarms from other regions, diminishing social preparedness in the low-infrastructure region. These interactions also prevent a warning strategy that optimizes the natural science-based index (i.e., threat score) from maximizing social efficiency. Conversely, in a society that has a region characterized by a high infrastructure level (i.e., a region with infrequent floods), regional interactions enhance the efficiency of FEWS by improving social preparedness through indirect experiences with floods. These findings suggest that as regional heterogeneity increases, it becomes increasingly vital for forecasters to consider social aspects (e.g., people's experiences, trust, and interactions) when establishing a socially efficient FEWS.
Enhanced Antitumor Effects of Thymoquinone in Combination with Paclitaxel on Hepatocellular Carcinoma Cell Lines: Role of P53 Modulation
Authors: Habib Tito N.
Published: August 2023

Background
Hepatocellular carcinoma (HCC) is a highly lethal disease with limited response to chemotherapy. Understanding the molecular mechanisms and drug resistance in HCC is crucial for developing effective therapeutic strategies. This study focuses on two widely used HCC cell lines, HepG2 and SNU-449, to investigate the combination treatment of paclitaxel (PTX) and thymoquinone (TQ). PTX is a potent chemotherapeutic agent that stabilizes microtubule structure and induces cell cycle arrest, but resistance remains a challenge. TQ has shown promising anticancer effects.
Methods
The antitumor effects of mono- and combined drug treatments were assessed in HepG2 and SNU-449 cell lines, including cell viability, cell cycle arrest, and apoptosis.
Results
The combination treatment synergistically enhanced the antitumor effects of PTX and TQ. It significantly reduced viable cell numbers, increased caspase-3 activation, and elevated annexin V staining. Interestingly, the combination induced differential cell cycle arrest patterns, with HepG2 cells shifting to the S phase and SNU-449 cells showing an increased G2/M cell population. PTX alone induced apoptosis in both cell lines, and TQ exhibited a similar apoptotic effect. The combined treatment further potentiated the apoptotic effect. P53, a tumor suppressor gene, was upregulated by PTX and/or TQ in the tested cell lines, suggesting its role in modulating the treatment response. P53 knockdown enhanced the antitumor properties of PTX and TQ in both cell lines.
Conclusion
The combination therapy of TQ and PTX holds promise as a potential therapeutic regimen for HCC. P53 may have a dual role, acting as a tumor suppressor and a cell protector under stress conditions. Targeting the down-regulatory mechanisms of P53 could be a valuable therapeutic approach, particularly in cancers with wild-type P53.
Kaposi’s sarcoma-associated herpes virus (KSHV) may not be associated with substance abuse in oral cancer patients: A retrospective case review.
Authors: Perera Manosha Lakmali , Perera Irosha Rukmali , Gunathilake Sharika , Silva Somila
Published: August 2023

Human Herpes virus 8 (HHV 8) better known as Kaposi’s sarcoma-associated herpes virus (KSHV) frequently relates to malignancies in acquired immune deficiency syndrome (AIDS) patients. Interestingly, one incident reported in a head and neck cancer patient who is also a HIV patient. In the light of these findings, this original research aimed to detect the HHV-8 status in oral squamous cell carcinoma tissues of Sri Lankan male patients. Incisional biopsies of cases were collected, transported, stored, and dispatched as frozen tissues at -800 C. A sub case sample selected from a large case control study to represent the vast majority of the oral cancer patients, in Sri Lankan context as oral cancer remains number 1 among Sri Lankan males. The DNA was extracted from frozen specimens using Gentra Puregene Tissue kit (Qiagen, Germany), solid tissue protocol according to the manufacturer’s instructions. The real-time PCR was performed with the specific primers to find out the possible association of this virus on substance abuse of OSCC patients in Sri Lanka. These data were obtained by a pre tested interviewer administered questioner were entered and analyzed using SPSS-21 Statistical Package. However, the HHV-8 DNA did not find in 22 OSCC cases. Kaposi’s sarcoma-associated herpes virus (KSHV) may not be associated with substance abuse in oral cancer patients. Powered longitudinal studies and invitro studies recommended to find out possible implication oral risk habits on this virus and activation of latent KSHV in B lymphocytes due to carcinogenic compounds in substances abused by OSCC patients.
Revisiting 2-Deoxyglucose Resistance in Neurospora crassa: Insights into Transcriptional Regulation of Hexose Transporters, Sugar Metabolism and Possible Modulation by Mating Type.
Authors: Pandey Rishikesh , Das Prabhu Kaibalya , Mishra Suruchee Samparna , Bulusu Vinay , Ramakrishnan Mukund
Published: August 2023

Background:
2-Deoxyglucose (2DG) has been used as an antimetabolite since the 1950s, however, mechanisms associated with its toxicity continue to be evaluated. Studies on 2-DG resistance in Neurospora have identified and characterized some mutants, including rco-3 (NCU02582) and exo-1 (NCU09899). Compared to yeast what is known in terms of genes and mechanisms, our knowledge of this phenomenon in filamentous fungi is still sketchy, though growing. We felt that examining, various aspects of Carbon Catabolite Repression for a certain group of dgr mutants might provide us with some insights.
Methods:
In the present manuscript, we have employed physiological as well as transcriptional approaches to better understand various properties associated with dgr strains vis-à-vis other known hexose transporter knockouts ∆ hgt-1 (NCU10021), ∆ hgt-2 (NCU04963), ∆ glt-1 (NCU01633) as well as glucose sensors such as ∆rco-3 (NCU02582), the dgr mutants included in this study are dgr-L1 ‘a’, dgr-L1 ‘A’, dgr (BEX5) ‘a’ and dgr (BEX6) ‘a’.
Results:
We make the following observations regarding the phenotypes associated with the dgr strains (i.e. including dgr(L1), dgr (BEX5) and dgr (BEX6)). (i) In conditions involving both low and high glucose we see altered expression associated with hexose transporters (glt-1, hgt-1 and hgt-2) as well as xylose metabolism regulators (xlr-1) (ii) We observe differential response as measured in terms of growth with regards to mating type (iii) We also observe differential sensitivity with regards to pH of the dgr mutants (iv) Finally we also propose a rapid method by which Glucose uptake can be monitored microscopically using the fluorescent analogue 2-NBDG used to successfully validate uptake in the dgr mutants used in this study.
Coping Strategies of the Inhabitants of Collaborative and Regular Housing Arrangements during the COVID-19 Pandemic: An Emerging Conceptual Re-elaboration of the Underlying Mechanisms through an Integrative Literature Review
Authors: Khatibi Maryam , Höpler Ruth , Aksumer Gizem
Published: August 2023

This review revisits the literature on collaborative and regular housing focusing on the intersection of housing affordability, social integration and health during the COVID-19 pandemic. Collaborative housing is an umbrella term that generates space not only for socio-spatial alternatives but also for alternative economic and legal frameworks in the context of housing. Hence, collaborative housing broadens the scope of regular housing by enabling the appropriation of common spaces by the inhabitants, encouraging social interaction, promoting sharing practices, self-organisation and collective solidarity in everyday life. Little is known about the challenges, experiences and mechanisms underlying the coping ways by which inhabitants dealt with the COVID-19 pandemic. Through an integrative literature review methodology, this study explores (1) How was unwanted isolation experienced during the COVID-19 pandemic?, (2) How did residents cope with the pandemic?, and (3) Which spatial solutions contributed to their well-being? This review includes 50 peer-reviewed articles, ten reports and 12 grey literature publications in three linguistic areas of English, German, and French in the timeframe of 2020–2022. Enriching the COVID-19 research in the context of housing, the review contributes to the synthesis of a state-of-the-art knowledge space by representing an emerged conceptual re-elaboration of coping responses in the context of regular and collaborative housing settings. Thus, the essence of this integrative review approach catalysed the unearthing of the underlying mechanisms of coping strategies and their causal explanations. Insights from various perspectives are extracted and organised to make them accessible to all while the elaboration for future research is identified.
On the Impact of Jaccard Fusion with Numerical Measures for Collaborative Filtering Enhancement
Authors: Amer Yasmeen A. , Abdalla Hassan I. , Nguyen Loc , Al-Maqaleh Basheer Mohamad
Published: August 2023

Collaborative filtering (CF) is an important method for recommendation systems, which are employed in many facets of our lives and are particularly prevalent in online-based commercial systems. The K-nearest neighbors (KNN) technique is a well-liked CF algorithm that uses similarity measurements to identify a user's closest neighbors in order to quantify the degree of dependency between the respective user and item pair. As a result, the CF approach is not only dependent on the choice of the similarity measure but also sensitive to it. However, some numerical measures, like cosine and Pearson, concentrate on the size of ratings, whereas Jaccard, one of the most frequently employed similarity measures, concerns the existence of ratings. Jaccard, in particular, is not a dominant measure, but it has long been demonstrated to be a key element in enhancing any measure. Therefore, in our ongoing search for the most effective similarity measures for CF, this research focuses on presenting combined similarity measures by fusing Jaccard with a multitude of numerical measures. Both existence and magnitude would benefit the combined measurements. Experimental results, on movielens-100K and Film Trust datasets, demonstrated that the combined measures are superior, surpassing all single measures across the considered assessment metrics.
Empirical association between COVID-19 confirmed cases, hospitalizations, vaccination, and travel: Comparison among different regions and provinces in Belgium between April-July 2021
Authors: Natalia Yessika Adelwin , Molenberghs Geert , Neyens Thomas , Hens Niel , Faes Christel
Published: August 2023

Objectives
In the absence of definitive treatment or vaccines, non-pharmaceutical interventions remain the major strategy to counter the COVID-19 pandemic. By the end of 2020, vaccines against COVID-19 had been developed and started as a preventive measure. In this study, we explored the effect of incoming travel rate combined with vaccination rate on COVID-19 incidence and hospitalization in Belgium between April-July 2021.
Methods
Data on COVID-19 confirmed cases and hospitalizations in Belgium were analyzed using a linear regression model (for data at the regional level) and a linear mixed model (for data at the provincial level).
Results
We found that incoming travel rate and vaccination rate have a significant effect on COVID-19 incidence and hospitalization at different administrative levels, provided appropriate transformations are applied and interactions added, suggesting non-linear effects of these explanatory variables.
Conclusion
Our findings suggest that surveillance on incoming travel would have been important to prevent COVID-19 transmission.
Editorial: Celebrando o apoio da comunidade científica em meio a desafios
Authors: Paz Ronilson José da
Published: August 2023

Editorial: Celebrando o apoio da comunidade científica em meio a desafios.
Avaliação das características biométricas da Moringa oleifera Lam. submetida à adubação orgânica
Authors: Nascimento Riusle Souza , Souto Lauter Silva , Luna Rômulo Gil , Souza Anielson dos Santos , Dutra Filho João de Andrade , Sá Francisco Vanies da Silva , Souto José Cavalcante Silva , Dantas José Altair Pereira
Published: August 2023

O uso de restos de cultivos e de esterco de gado tem sido frequentemente utilizado como adubação orgânica visando a combater deficiências nutricionais e o progressivo empobrecimento de solos agrícolas. O presente estudo teve por objetivo avaliar o efeito de níveis de adubação orgânica na produção de mudas de moringa (Moringa oleifera Lam.), nas condições semiáridas da Paraíba. O experimento foi conduzido em condições de túnel plástico, localizado na Universidade Federal de Campina Grande, Campus de Pombal, Estado da Paraíba. Utilizou-se o delineamento em blocos casualizados, com os tratamentos compostos de quatro níveis de adubação orgânica (107,0, 215,0, 430,0 e 860,0 g.vaso-1), com seis repetições. Foram avaliados aos 30 e 60 dias após a emergência (DAE) as seguintes variáveis: diâmetro do caule, altura de planta, massa seca da parte aérea, massa fresca da parte aérea, comprimento da raiz, massa fresca da raiz, massa seca de raiz, massa seca total, massa fresca total e razão parte aérea/raiz. Aos 30 e 60 DAE houve um incremento para diâmetro de caule, comprimento de raízes e altura de plantas em funções dos níveis de fertilização orgânica aplicados. O acréscimo nos níveis de adubação orgânica adicionados ao solo proporcionou um aumento significativo na produção de massa fresca da parte aérea e de raiz, bem como a produção de biomassa fresca e seca da planta e a razão parte aérea/raiz. A adição dos diferentes níveis resultou em ganhos significativos no desenvolvimento das mudas, sendo que para as condições do presente estudo a aplicação de 430,0 g.vaso-1 foi suficiente para promover um crescimento e desenvolvimento mais adequado das mudas de moringa. A adição de esterco bovino pode ser recomendada para produção de mudas como fonte de nutrientes e condicionador do solo.
Diagnóstico ambiental do Córrego Brejinho, em Araguatins, Tocantins
Authors: Araújo e Silva Thiago de Loiola , Macedo Karla Gonçalves , Novaes Luciano Faria de , Colen Aymara Gracielly Nogueira , Vitorino Sílvia Maria Aparecida , Silva Maria Cleiciane Sá da
Published: August 2023

As matas ciliares é toda vegetação que acompanha os corpos d'água, com a função de auxiliar na manutenção da fauna e flora e promover a estabilidade ambiental. São protegidas por lei, portanto deve-se avaliar se são respeitadas. Uma das formas de ser verificada a conformidade destas áreas é através de um diagnóstico ambiental. Portanto, objetiva-se por meio do presente trabalho realizar o referido diagnóstico ambiental da mata ciliar do Córrego Brejinho, localizado no Município de Araguatins-TO. O corpo hídrico pertence à Bacia Hidrográfica do Rio Araguaia, medindo 1,45 km de extensão, localizado na área urbana municipal. O diagnóstico foi realizado por meio de geoprocessamento, visitas in loco e na caracterização da área, onde foram observados os impactos existentes no local e identificação das causas dessa degradação, sendo de origem antrópica e/ou natural. Após a identificação os impactos foram listados, registrados por meio de fotografias e classificados de acordo com os critérios de classificação dos impactos ambientais em ordem, valor, dinâmica, tempo, plástica e espaço. Além disso, a área da mata ciliar existente no corpo hídrico foi mensurada usando o geoprocessamento. Dessa forma, os impactos mais recorrentes observados foram a supressão da mata ciliar, assoreamento, deposição inadequada de resíduos sólidos e a ocupação humana. Como medidas mitigadoras para a contenção da degradação na área de estudo, o proposto é que seja criada uma parceria com o poder executivo municipal para realizar o isolamento da área, fomentar a fiscalização ambiental e elaborar Plano de Recuperação de Áreas Degradadas (PRAD).
Economia circular como mecanismo de gestão ambiental: utilização de RAP em camadas de revestimento asfáltico
Authors: Mendes Lara Pereira Tavares , Bezerra Ana Leticia Ramos , Souza Milena Cristina Rocha de , Ribeiro Libânia da Silva , Guedes Leonardo Rodrigues
Published: August 2023

Com a crescente preocupação relacionada aos impactos ambientais causados pelas atividades do setor de infraestrutura de transportes, tem-se buscado soluções para a reutilização dos resíduos gerados pelo fim da vida útil dos pavimentos. O presente artigo tem como proposta abordar o conceito de economia circular como mecanismo da gestão ambiental incorporado na indústria da pavimentação. Foi analisado o potencial de incorporação do Reclaimed Asphalt Pavement (RAP) na produção de novas misturas asfálticas. Como abordagem metodológica foi utilizada uma revisão sistemática de literatura que utilizou critérios de inclusão e exclusão para seleção dos trabalhos a fins da questão de pesquisa. A partir da análise dos trabalhos selecionados constatou-se que o emprego do RAP em misturas asfálticas é capaz de oferecer benefícios ambientais, como também bom desempenho mecânico.
Pea crab-oyster interspecific interaction on tropical coast: Brachyuran pinnotherid Zaops ostreum (Say, 1817) living in the host bivalve ostreid Crassostrea brasiliana (Lamarck, 1819)
Authors: Costa Dimítri de Araújo , Lima Silvio Felipe Barbosa , Maciel Moniky Mendes , Alves-Júnior Flavio de Almeida , Souza José Weverton Santos
Published: August 2023

In this study, we report the association between the pea crab Zaops ostreum (Say, 1817) living in the oyster Crassostrea brasiliana (Lamarck, 1819), collected in an estuarine region of Northeast Brazil. Oysters were collected along the mouth of the Santa Cruz Channel, Barra de Catuama (State of Pernambuco), between 2016 and 2017. A total of 224 oysters and 38 crabs were collected. Relative density of Z. ostreum was 16.96% (7.14% for males and 9.82% for females) in analyzed oysters. Prevalence during dry season ranged from 6.25% to 15.60%, whereas in rainy season ranged from 3.10% to 12.50%. Z. ostreum proportion of females to males was 1:0.73. Most occurrences were female-male couples (79.29%) with no isolated males or triple occupancy being observed. Female-male couples and ovigerous females were detected throughout most of the studied period, possibly indicating a distinct reproduction behaviour on tropical areas. This association expands knowledge on the aspects of social behaviour and host range of Z. ostreum, remarkably associated with bivalves of the Family Ostreidae.
O uso das redes neurais artificiais para obtenção de índices de sustentabilidade de edifícios habitacionais: revisão sistemática da literatura
Authors: Costa Carlos Alberto da , Romano Cezar Augusto
Published: August 2023

A demanda por edifícios mais sustentáveis tem relação com os impactos deste setor, onde a depleção de recursos, incluindo energia, a geração de resíduos e as significativas emissões de gases de efeito estufa, que influem nas mudanças climáticas, dentre outros severos danos, se somam à informalidade e fatores de risco aos operários. As muitas peculiaridades envolvendo os edifícios em seu ciclo de vida pedem métodos de avaliação ponderados, capazes de agregar indicadores para prever o desempenho de diretrizes a eles aplicadas, permitindo a tomada de decisão, em meio à complexidade, sobretudo na construção habitacional. Assim, o objetivo desta pesquisa foi realizar uma revisão sistemática da literatura voltada à aplicação de métodos que se utilizam das Redes Neurais Artificiais para analisar indicadores ambientais, sociais e econômicos; deles obtendo índices de sustentabilidade para os edifícios habitacionais. As abordagens para este fim foram encontradas em 61 de 134 artigos selecionados, porém, a aderência envolvendo índices foi notada somente em oito destes artigos, os quais se apoiaram em poucos indicadores, quase sempre representando diretrizes, ou seja, ações para promover a sustentabilidade. Portanto, verificou-se carência de indicadores da performance produzida por tais diretrizes. Ficou evidente também o desafio de se fazer comparações por meio de um edifício de referência, representante do modo convencional de construção com o qual se está insatisfeito, gerando índices para outros edifícios planejados como sustentáveis.
Slightly broken higher-spin current in bosonic and fermionic QED in the large-$N$ limit
Authors: Zhou Zheng , He Yin-Chen
Published: August 2023

We study the slightly broken higher-spin currents in various CFTs with U(1) gauge field, including the tricritical QED, scalar QED, fermionic QED and QED-Gross-Neveu-Yukawa theory. We calculate their anomalous dimension by making use of the classical non-conservation equation and the equations of motion. We find a logarithmic asymptotic behaviour (\gamma_s\sim 16/(N\pi^2)γs∼16/(Nπ2) log s ) of the anomalous dimension at large spin ss, which is different from other interacting CFTs without gauge fields and may indicate certain unique features of gauge theories. We also study slightly broken higher-spin currents of the SU(N)_11 WZW model at d=2+\epsilond=2+ϵ dimensions by formulating them as the QED theory, and we again find its anomalous dimension has a logarithmic asymptotic behaviour with respect to spin. This result resolves the mystery regarding the mechanism of breaking higher spin currents of Virasoro symmetry at d=2+\epsilond=2+ϵ dimensions, and may be applicable to other interesting problems such as the 2+\epsilon2+ϵ expansion of Ising CFT.
Turbulence modelling for depth-averaged velocity and boundary shear stress of a dense rigid grass bed open channel
Authors: Sahoo Sarjati , Khuntia Jnana Ranjan , Devi Kamalini , Sai Prasad B. Sree , Kumar Khatua Kishanjit
Published: August 2023

The present research focusses on a comparison of experimental and numerical approaches for flow over fixed artificial rigid grass bed channels. Various flow parameters like longitudinal velocity, depth-averaged velocity (DAV), boundary shear stress (BSS) and secondary current are analysed and compared with seven numerical models: standard, realizable and renormalization group (RNG) k–ε models and standard, shear stress transport (SST), generalized k–ω (GEKO) and Baseline (BSL) k–ω models. To evaluate the strength of the seven applied models, the error analysis has been performed. It is found that the RNG k–ε and SST k–ω models provided better results for both the DAV and BSS prediction, but the RNG k–ε model is found to be the most suitable for predicting the DAV and the SST k–ω model for BSS as compared to the other models. For the longitudinal velocity profiles, both the RNG k–ε and SST k–ω models are found to provide good agreement with experimental results at the centre of the channel, whereas the SST k–ω model is more accurate near the wall. Overall, the SST k–ω model has predicted the results with good accuracy for all the flow parameters considered in the present study.
Methodology for the study of the traceability of runoff water feeding reservoirs
Authors: Ortega Lidia M. , Ramos M. Isabel , Enríquez Turiño Carlos , José Cubillas Mercado Juan
Published: August 2023

Water reservoirs are essential to ensure water supply to both the population and agriculture, especially in the Mediterranean basin. In some cases, analyses of water intended for human consumption have detected high levels of agrochemicals. Knowing the possible origin of these products is complex because there may be many agricultural plots within the reservoir basin. In this paper, we introduce a methodology to obtain the set of agricultural plots whose rainwater reaches the reservoir and in what proportion they affect the points where chemical analyses are performed. The method implements an extension of the D8 algorithm for the calculation of the drainage network, in which additional information about the land-use type of the area, as well as rainfall maps, are also considered. In order to facilitate the user's analysis of the data, a plugin has been implemented in QGIS. This allows usability and easy interaction with the visual information. The Rumblar reservoir basin, located in Andalusia (Spain) has been studied as a use case, surrounded by olive orchards. The result is a replicable methodology for any other water reservoir and for carrying out an individualized study of agricultural plots.
Assessment, classification and mapping of groundwater quality for agriculture in selected farm settlements of southwestern Nigeria
Authors: Folarin Gbolahan Muyiwa , Badmus Biodun Suraj , Akinyemi Olukayode Dewunmi , Idowu Olufemi Abiola , Oke Adebayo Olubukola , Omodele Taiwo , Badmus Ganiyu Olabode
Published: August 2023

Good water quality is very vital to the productivity and sustainability of irrigated agriculture. The suitability for irrigation of groundwater samples collected and analyzed during dry and wet seasons from Ajegunle, Akufo and Eruwa farm settlements of southwestern Nigeria were assessed using several irrigation water quality indices (IWQIs). The parameters were analyzed statistically and subjected to correlation. Seasonal spatial distribution maps were generated via GIS. All the water samples from the three farm settlements were found to be mostly soft, fresh, excellent, and suitable for irrigation in both seasons. Meanwhile, soluble sodium percentage (SSP) and Kelley's Ratio (KR) revealed them as unsuitable while other parameters showed different degrees of suitability for different samples from different farm settlements in different seasons. Significant correlations were seen between the selected parameters in both seasons. The distribution maps reveal the spatial distributions of selected parameters within Ajegunle and Akufo farm settlements. Utilizing these findings will enhance systematic groundwater exploitation for irrigation within the settlements. Furthermore, systematic irrigation management practices and crop choices, based on the concentrations and distribution of the parameters viz-a-viz crop requirements should be considered to limit potential dangers that may arise with the use of the water over a long period.
‘MODUS OPERANDI’ SPRAWCY PRZESTĘPSTWA KARNEGO W ROZWAŻANIACH RZYMSKIEJ JURYSPRUDENCJI?
Authors: Amielańczyk Krzysztof
Published: August 2023

W dobie integracji i budowy europejskiego prawa karnego, rzymskie postrzeganie przestępstwa może wzbogacić dyskusję nad europejską koncepcją sprawstwa czynu kryminalnego o doświadczenie historyczne. Wprawdzie juryści rzymscy nie rozwinęli nauki o przestępstwie karnym, podejmowali jednak nieliczne próby opisania istoty przestępstwa prawa publicznego. Stylistyka wywodów Claudiusa Saturninusa i Paulusa może budzić dalekie skojarzenia z pojęciem modus operandi sprawcy przestępstwa, znanym współczesnej kryminologii. Juryści tworząc modele sposobów popełniania przestępstw opierali się na opisach przestępstw znanych im z leges iudiciorum publicorum, ale ograniczyli się głównie do strony przedmiotowej przestępstwa. Problematyka modus operandi w prawie rzymskim wymaga zatem dalszych badań uwzględniających specyfikę norm rzymskiego prawa karnego, którą wyraża penalizacja wskazanych w ustawach różnorodnych sposobów działania sprawców czynów kryminalnych.
UMOWY SPADKOWE W EDYKCIE JUSTYNIANA 'DE ARMENIORUM SUCCESSIONE' Z 535 R.
Authors: Grebieniow Aleksander
Published: August 2023

Prawo justyniańskie zawiera wiele świadectw wykorzystywania umów w sprawach dotyczących następstwa prawnego mortis causa. Jednym z przykładów jest mało znany Edykt Justyniana z 535 r. De Armeniorum successione. Edykt wydany został w celu politycznej i prawnej integracji Armenii z Cesarstwem, tak ważnej wobec stałego wówczas zagrożenia ze strony Sassanidów. Na marginesie głównych postanowień edykt zawiera wzmiankę o stosowaniu ugód, którymi nota  bene skutecznie modyfikowano testamentowy porządek dziedziczenia już od okresu klasycznego, oraz o enigmatycznych „innych pacta”. Pozostałe źródła prawne mogą zawierać wskazówki, jakie porozumienia spadkowe miał na myśli cesarz Justynian. Wydaje się, że Ed. 3, potwierdzając lokalną praktykę prawną, wskazuje jednocześnie na jej podobieństwo do niezależnie wykształconej praktyki stosowania prawa rzymskiego w tym zakresie.
The Critical Function of microRNAs in Developing Resistance against 5-
Fluorouracil in Cancer Cells
Authors: Sheikhnia Farhad , Maghsoudi Hossein , Majidinia Maryam
Published: August 2023

Although there have been significant advancements in cancer treatment, resistance and recurrence
in patients make it one of the leading causes of death worldwide. 5-fluorouracil (5-FU), an
antimetabolite agent, is widely used in treating a broad range of human malignancies. The cytotoxic
effects of 5-FU are mediated by the inhibition of thymidylate synthase (TYMS/TS), resulting in the
suppression of essential biosynthetic activity, as well as the misincorporation of its metabolites into
RNA and DNA. Despite its huge benefits in cancer therapy, the application of 5-FU in the clinic is
restricted due to the occurrence of drug resistance. MicroRNAs (miRNAs) are small, non-coding
RNAs that act as negative regulators in many gene expression processes. Research has shown that
changes in miRNA play a role in cancer progression and drug resistance. This review examines the
role of miRNAs in 5-FU drug resistance in cancers.
Electroacupuncture Pretreatment Alleviates Cerebral Ischemia-reperfusion Injury by Down-regulating Mir-155-5p
Authors: Li Xuejing , Wang Ying , Zhou Xiang , Wang Hui , Xu Jiang
Published: August 2023

Background:

Increasing evidence shows that electroacupuncture pretreatment (EP)
plays a crucial role in cerebral ischemia-reperfusion (I/R) injury, and cerebral I/R injury is the most
serious complication of ischemic stroke treatment. The role of miR-155-5p in cerebral I/R injury
has been studied, but the regulation of EP on miR-155-5p has not been reported.

Methods:

The middle cerebral artery occlusion (MCAO) mice were used to investigate the role of
EP in cerebral I/R injury. Longa and modified neurological severity scores (mNSS) were used to
evaluate neurological impairment. HE staining and TUNEL staining were used to evaluate brain
injury. The expressions of miR-155-5p, Yin Yang 1 (YY1) and p53 were detected by qRT-PCR.
The expressions of related proteins were detected by western blot. The binding of YY1 to miR-
155-5p was verified by dual-luciferase reporter assay and chromatin immunoprecipitation (ChIP)
assay. Mice brain microvascular endothelial cells (BMECs) were isolated and cultured for in vitro
experiments. Oxygen-glucose deprivation/reoxygenation (OGD/R) was used to verify the role of
YY1, p53 and miR-155-5p in cerebral I/R injury in vitro.

Results:

MCAO modeling induced brain injury, apoptosis, and increased levels of miR-155-5p,
YY1, and p53. EP markedly alleviated brain injury and reduced levels of miR-155-5p, p53, and
YY1. miR-155 agomir markedly increased the expression of miR-155-5p and p53. miR-155 antagomir
decreased the levels of miR-155-5p and p53. Dual-luciferase reporter and ChIP assay verified
that YY1 regulated miR-155-5p expression. YY1 shNRA greatly decreased miR-155-5p and
p53. Inhibition of p53 decreased miR-155-5p expression. Both miR-155-5p inhibitor and YY1
shRNA promoted proliferation, inhibited apoptosis, and decreased levels of ICAM-1 and Eselectin
of OGD/R-treated BMECs. Inhibition of p53 strengthened the effect of miR-155-5p inhibitor
and YY1 shNRA on BMECs.

Conclusion:

Electroacupuncture pretreatment alleviates cerebral ischemia-reperfusion injury by
regulating the YY1/p53/miR-155-5p axis.
The Role of METTL3 in the Progression of Cardiac Fibrosis
Authors: Bolívar Samir , Pérez-Cantillo Marian , Monterroza-Torres Jassiris , Vásquez-Trincado César , Castellar-Lopez Jairo , Mendoza-Torres Evelyn
Published: August 2023

Cardiac fibrosis is known as the expansion of the cardiac interstitium through excessive
deposition of extracellular matrix proteins; this process is performed by a multifunctional cell
known as the cardiac fibroblast. After the myocardial injury, these cells are activated as a repair
program, increase, and switch to a contractile phenotype, which is evidenced by an increase in alpha-
smooth muscle actin. Likewise, there is an increase in type I and III collagen, which are considered
profibrotic biomarkers. It is believed that one of the proteins involved in cardiac remodeling is
METTL3, which is the enzyme responsible for N6-methyladenosine (m6A) methylation, the most
common and abundant epigenetic modification of eukaryotic mRNA. This review focuses on recent
studies in which the possible role of METTL3 in the progression of fibrosis has been demonstrated,
mainly in cardiac fibrogenesis.
2.4 GHz Compact Textile Antenna for Body Wear Application and
Monitoring of Health Parameters
Authors: Ghodake Asha Pandit , Hogade B.G.
Published: August 2023

Background:

This paper has described a textile-based body-worn antenna. When compared
to standard flat and stiff antennas and circuits, this technology delivers superior mechanical and radio
frequency performance. Textile antennas have several advantages, including small size, lightweight,
ease of fabrication, and low cost. As a result of these advantages, textile antennas are gaining popularity
these days.

Objective:

There are different applications of textile antennas, but the main application or aim is to wear
them comfortably and observe different body signals for analysis of different health parameters, like
temperature, heart rate, blood pressure, etc., as the compactness of the antenna bending losses is less.

Methods:

In the design of an antenna, jeans fabric is employed as the substrate because this material is
sturdy, stiff, of little density, accessible, and inexpensive with electromagnetic properties ℇr = 1.6 and
tan ẟ = 0.01, and copper is used for the conducting patch and ground.

Result:

This antenna operates in the industrial, scientific, and medical radio (ISM) band at 2.4 GHz
with patch dimensions of 25 x 20 mm, making it proper for body-worn purposes. Because the antenna is
so small, it can be readily mounted on an arm for health parameter monitoring with minimal bending. In
sweaty conditions, it also operates in the ISM band.

Conclusion:

The simulation, fabrication, and body wear results are all included in the results section.
As a result, these novel fibre antennas are useful to incorporate into shirts and coats for easy health
monitoring with minimum loss.
Dynamic Simulation Analysis of Truck Crane Based on ADAMS
Authors: Xin Yunsheng , Dong Ruiyi , Lv Shuyi
Published: August 2023

Background:

With a reduction in the weight of telescopic boom crane and an increase in its
lifting capacity, the contradiction between its speed, stability and safety becomes more prominent. The
telescopic arm also has flexible deformation during operation, which will cause vibration of the whole
vehicle system. Therefore, in order to ensure safety, accuracy, and efficiency in the working process, it is
necessary to accurately predict the dynamic characteristics of the telescopic boom load in the working
process.

Objective:

The purpose of this study is to establish a rigid-flexible coupling dynamic model of the crane,
which can accurately reflect the dynamic characteristics of the telescopic boom during its operation in the
simulation test.

Methods:

In theory, this study analyzes the characteristics of a truck crane and simplifies it as a cantilever
beam. Based on the Euler-Bernoulli beam theory, the vibration differential equation of the mobile masscantilever
beam system is established. In the aspect of simulation, the three-dimensional modeling software
Solidworks is used to establish the solid model of the truck telescopic boom, the finite element analysis
software is used to establish the finite element model of the telescopic boom, and the modal neutral
file is generated and imported into ADAMS to establish the dynamic model of the truck crane multi-level
flexible telescopic boom. The dynamic simulation of the virtual prototype model of the truck telescopic
boom crane is carried out in ADAMS software to obtain the dynamic characteristics of the key components
of crane under specific working conditions.

Results:

The vibration differential equation derived in theory can be used to solve the dynamic response
of the crane jib under specific conditions by MATLAB programming. In the aspect of simulation, the
error fluctuation and its causes in the key components of the crane in the working state are analyzed, and
the rationality of the virtual prototype model is verified. Finally, through the trajectory planning of the
crane under typical working conditions, the purpose of stable control of the telescopic boom system of the
truck crane is realized.

Conclusion:

The derived equation is universal for solving the vibration of crane jib in general cases. The
rigid-flexible coupling model also provides a reference for the dynamic modeling, analysis, design, and
manufacture of a multi-stage flexible telescopic boom. The findings of this study can provide a reference
for related patent research and development.
Improved Enhanced Oil Recovery – Role of Sonication: An Overview
Authors: Malani Ritesh S. , Saha Rahul
Published: August 2023

Crude oil is one of the prominent resources to fulfill the need of day-to-day
life. With few reservoirs, the proper utilization and maximization of oil recovery from
existing oil wells are one of the foremost objectives in today’s scenario.
Conventionally, the inbuilt pressure and artificial pumping followed by water flooding
could result in 30-50% of oil recovery. Thus, to produce the remaining residual crude
oil, various enhanced oil recovery methods are adopted, including gas flooding, fire
flooding, chemical EOR, etc. Still, oil recovery in large quantities persists to be a
challenging task for engineers throughout the world. The major limitation for
improving the oil recovery is the water enrichment of the reservoirs, which governs the
oil displacement efficiency from the reservoir to the production platform.
The application of sound waves in reservoir engineering is an established technology.
In seismic surveys, sound waves of various frequencies have been used to predict oil
and gas reserves. The advancement of the application of ultrasound irradiation on
multiple sectors, including the enhancement of oil recovery from wells, has also been
analyzed and tested. The idea behind applying cavitation technology is that the passage
of ultrasound waves releases the energy in terms of transient cavitation and allows the
formation of the fine emulsion of two immiscible phases. The emulsion enables the
improvement of oil movability toward the production well without changing the
porosity and permeability of rocks. Thus, the cavitation technique can be applied to
estimate oil-water saturation in reservoirs and can further improve the oil recovery
factor. This chapter emphasizes the fundamentals of enhanced oil recovery schemes,
their mechanisms, and the application of ultrasound irradiation toward improved oil
recovery.