bluuebunny/crossref_metadata_2025 huggingface dataset:
Timely detection of Pertussis outbreaks in Iran: The comparison performance of Wavelet-based outbreak detector, Exponential weighted moving average, and Poisson regression-based methods
Authors: Alimohamadi Yousef , Zahraei Seyed Mohsen , Karami Manoochehr , Yaseri Mehdi , Lotfizad Mojtaba , Holakouie-Naieni Kourosh
Published: February 2020

Background Early detection of outbreaks is very important for surveillance systems. Due to the importance of the subject and lack of similar studies in Iran, the aim of this study was to determine the performance of the Wavelet-Based Outbreak detection method)WOD(in detecting outbreaks and to compare its performance with Poisson regression-based model and Exponential weighted moving average (EWMA) using data of simulated pertussis outbreaks in Iran. Methods The data on suspected cases of pertussis from 25th February 2012 to 23rd March 2018 in Iran was used. The performance of the WOD (Daubechies 10 and Haar wavelets), Poisson regression-based method, and EWMA Compared in terms of timeliness and detection of outbreak days using the simulation of different outbreaks (literature-based and researcher-made outbreaks). The sensitivity, specificity, false alarm and false negative rate, positive and negative likelihood ratios, under ROC areas and median timeliness were used to assess the performance of the methods. Results In a literature-based outbreak simulation, the highest and lowest sensitivity, false negative in the detection of injected outbreaks were seen in Daubechies 10 (db10), with sensitivity 0.59 (0.56-0.62), and Haar wavelets with 0.57 (0.54-0.60). In the researcher-made outbreaks, the EWMA (K=0.5) with sensitivity 0.92 (0.90-0.94) had the best performance. About timeliness, the WOD methods showed the best performance in the early warning of the outbreak in both simulation approaches. Conclusions Performance of the WOD in the early alarming outbreaks was appropriate. However, it's better as the method was used along with other methods in public health surveillance systems.
Serosurvey of anti-Toxoplasma gondii and anti-HIV antibodies in homeless persons of southeastern Brazil
Authors: Felipetto Laís Giuliani , Teider-Junior Pedro Irineu , Silva Felipe Fortino Verdan da , Yamakawa Ana Carolina , Kmetiuk Louise Bach , Couto Anahi Chechia do , Martins Camila Marinelli , Vaz Eduarda Stankiwich , Ullmann Leila Sabrina , Langoni Helio , Timenetsky Jorge , Santos Andrea Pires dos , Biondo Alexander Weilker
Published: February 2020

Background: Homeless persons have been described as one of the most vulnerable populations worldwide, with higher morbidity and mortality of diseases associated with HIV occurrence. Seroprevalence of Toxoplasma gondii and HIV has been extensively studied in other vulnerable populations, however, no study to date have focused on their concomitant seroprevalence in homeless persons. Accordingly, the present study aimed to assess the concomitant seroprevalence of anti-T. gondii and anti-HIV antibodies and associated risk factors in homeless persons in a daytime homeless shelter of São Paulo, southeastern Brazil. Methods: Anti-T. gondii antibodies were detected by indirect fluorescent antibody test and anti-HIV levels by chemiluminescence enzyme immunoassay, with positive samples confirmed by rapid immunoblot assay. Results: Overall, IgG anti-T. gondii seropositivity was found in 43/120 (35.8%) homeless persons, with endpoint titers varying from 16 to 1,024. The only two pregnant women tested were negative for IgM by chemiluminescence enzyme immunoassay, with normal parturition and clinically healthy newborns in both cases. There were no statistical differences in the risk factors for anti-T. gondii serology (p>0.05). Anti- HIV seropositivity was found in 2/120 (1.7%) homeless persons, confirmed as HIV-1. One HIV seropositive individual was also sero-reactive to IgG anti-T. gondii, and both were negative to IgM anti-T. gondii. One HIV positive person was also diagnosed with syphilis, tuberculosis and body lice presence, while the other never returned for assistance. No evaluation of anti- HIV risk factors has been made due to the low seropositive rate. Conclusions: The anti-T. gondii prevalence herein was lower than other Brazilian populations, likely related to predominant intake of processed food such as ready-to-eat and fast-food meals, and thus, low ingestion of fresh salad and raw meat. On the other hand, the anti- HIV seropositivity was higher than the average of the general Brazilian population, with 0.4%. Despite the low prevalence of anti-T. gondii in homeless persons, clinical manifestations may be aggravated in HIV positive individuals. To the author's knowledge, this is the first study of anti-T. gondii serosurvey in homeless persons concomitantly assessed with anti-HIV seropositivity.
Laboratory Findings on a Patient with Strongyloies Stercoralis Pulmonary Infection after Long Term Steroid Hormone and Immunosuppressive Treatment
Authors: Zhao Hongying , Deng Shuang , Liang Yuanzi , Qin Zhiqiang , Liang Li , Geradts Joseph , Huang Huayi
Published: February 2020

Background: Strongyloies stercoralis infection is common in tropical and humid areas worldwide. However, strongyloidiasis caused by Strongyloies stercoralis infection is often neglected in clinic. We report a misdiagnosed case of Strongyloies stercoralis infected female patient who had been admitted to four different hospitals for treatment, she eventually died upon Strongyloies stercoralis hyperinfection with pulmonary infection involved.Case presentation: A Strongyloies stercoralis infected woman was misdiagnosed as community acquired pneumonia, connective tissue disease and Sjogren's syndrome, and treated by mistake.She eventually died upon Strongyloies stercoralis hyperinfection with pulmonary infection involved. The patient’s clinical presentations, imaging results of the lungs, numerous Strongyloies Stercoralis larvae and eggs found in the stool, increased eosenophil count in peripheral blood, and elevated serological IgE level were evidences of Strongyloies stercoralis hyperinfection.Conclusion: The patient was infected with Strongyloies Stercoralis and died from the hyperinfection after long term use of immunosuppressive agents.
Appendicular skeletal muscle mass to truncal fat mass ratio as a new index for osteosarcopenic obesity syndrome in older adults: emphasizing the role of central obesity
Authors: Dwipa Lazuardhi , Widiastuti Rini , Rakhimullah Alif Bagus , Maharsidi Marcellinus , Pratiwi Yuni Susanti , Apandi Muhamad
Published: February 2020

Background The relationship between obesity and low bone mineral density (BMD) in older adults is still unclear. Most of the previous study did not account the factor of sarcopenia which is the progressive loss of skeletal muscle mass due to aging, and distribution of fat in obesity. Thus, this study was aimed to explore the correlation between appendicular skeletal muscle mass (ASMM), total fat mass (FM), and truncal fat mass (TrFM) as well as indexes (ASMM/FM and ASMM/TrFM ratio) with BMD in older adults.Methods This was an analytic cross-sectional study. Dual x-ray absorptiometry (DXA) and bioelectric impedance analysis (BIA) were used to assess BMD and body composition, respectively. Appendicular Skeletal Muscle Mass (ASMM) were used in the analysis to reflect sarcopenia, Fat Mass (FM) and Trunkal Fat Mass (TrFM) were used to reflect general and central obesity, respectively. All data were obtained from medical records of Geriatric Clinic of Hasan Sadikin General Hospital Bandung Indonesia from January 2014 to December 2018. The correlation between body compositions variable with BMD were analyzed using Spearman’s test. We also conducted a comparison analysis of body composition variables between low and normal BMD using Mann-Whitney test. Results A total of 112 subjects were enrolled in the study. ASMM and TrFM were positive (rs=0.517, p<0.001) and negative (rS=-0.22, p=0.02) correlated with BMD, respectively. FM were not correlated with BMD, rS=-0.113 (p=0.234). As indexes, ASMM/FM and ASMM/TrFM had positive correlation with BMD, rS=0.277 (p<0.001), and rS=0.391 (p<0.001), respectively. The ASMM, TrFM, and ASMM/TrFM ratio between normal and low BMD also significantly different (p<0.001), meanwhile FM were not (p=0.204).Conclusion ASMM and TrFM have a positive and negative correlation with BMD, respectively. ASMM/TrFM ratio as new sarcopenia-central obesity index has a positive correlation with BMD.
Impact of physical activity levels on cardiometabolic parameters and autonomic modulation in elderly: a cross-sectional study
Authors: Viana Ariane , Bugliani Neide , Sartori Michelle , Silva Camila Martins da , Sanches Iris Callado , Velardi Marília , Miranda Maria Luiza de Jesus , Angelis Katia De
Published: February 2020

Background: By 2030, approximately 20% of the population worldwide will be 65 years of age or older. In this age group, cardiovascular diseases (CVD) will result in 40% of all deaths. Heart rate variability (HRV) appears to be reduced under stress conditions and in many chronic diseases as cardiovascular diseases that appear to be associated with autonomic changes that usually include decreased parasympathetic activation and/or increased sympathetic modulation. Thus, aging is very important for altering neurohumoral mechanisms that control the cardiovascular system. Objective: To analyze the influence of level of physical activity in the HRV in elderly people. Methods: Cross-sectional analytical study which included 49 subjects (60 – 86 years), which answered the Baecke questionnaire. Results: The less physically active group had lower levels of plasma HDL (42±2.43mg/dL vs 52±3.8mg/dL) and higher systolic BP (131±117mmHg vs 117±4.07mmHg) when compared to the most active group. The more physically active group showed higher PI of variance (1849.6±387.7ms²) when compared to the moderate (892.1±141.9 ms²) and the less physically active groups (972.3±285.2 ms²). Moreover, the most physically active group presented lower LF/HF balance (1.6±0.2) when compared to the moderate (2.6±0.3) and the less active groups (2.5±0.2). Discussion: The results demonstrated the importance of physical activity to promote hemodynamic, autonomic and lipid profile improvement, suggesting a lower risk of developing or progressing the disease in the elderly.
Comparison of the diagnostic efficacy between transrectal prostate biopsy and transperineal cognitive fusion biopsy
Authors: Zhang Zhilei , Qin Fei , Jiao Wei , Yang Xuecheng , Li Yujun , Jiang Yanxia , Hao Dapeng , Li Jie , Zhou Ruizhi , Zhang Mingxin , Niu Haitao
Published: February 2020

Background: This study aimed to compare the detection efficacy of transrectal ultrasound -guided systematic prostate biopsy (TR-SB) and transperineal cognitive fusion targeted +systematic biopsy (TP-SB+COG-TB) in patients with suspected prostate cancer (PCa). In addition, the relative clinical characteristics of PCa were evaluated. Methods: 385 patients were enrolled in this study, who underwent transrectal (n=275) or transperineal (n = 110) cognitive fusion biopsy. Relative factors of PCa including age, prostate volume and PSA level were collected for multivariable analysis. The cancer detection rates were compared, and logistic regression was used to assess the impact of patient characteristics on PCa detection Results: For all patients, the overall detection rates of TR-SB and TP-SB+COG-TB were 121/275(40%) and 67/110（60.91%）, respectively. TP-SB+COG-TB detected a higher rate of PCa (P =0.003) and more clinically significant prostate cancers (csPCa) (P=0.001) than TR-SB. Logistic regression analyses revealed that age、TPSA（total prostate specific antigen）and PV were related to the detection rate of PCa (P≤0.05). Conclusion ： TP-SB+COG-TB could find more clinically significant PCa than TR-SB. Due to the high detection rate at certain ages, PSA levels and PV, patents’ clinical characteristics should be considered in biopsy.
Case report: a case of primary pulmonary glomus tumor
Authors: Deng shuangshuang , Huang Jianhao , Yin Qi , Gao Jinli , Wang Feilong , Lu Jingjing , Guo Zhongliang
Published: February 2020

Background Glomus tumors, as extremely rare tumors of the lung, since their rarity and the variety of the clinical symptoms, tend to be misdiagnosed. The location of these tumors as well as their early diagnosis is a pivot for the prognosis of the disease. Case presentation We report a case of old patient whose final diagnosis was primary pulmonary glomus tumor. She initially was found a nodule in the right lung, which was enlarged during follow-up and finally confirmed after surgery. Postoperative pathology was considered as a primary pulmonary glomus tumor. There has been no evidence of tumor recurrence or metastasis so far. Conclusion Primary pulmonary glomus tumor is rare. The clinical manifestations are related symptoms occupying lesions in the lung. The diagnosis of the tumor depends on histopathology and immunohistochemistry. Surgical resection is considered as the most eﬀective treatment for this condition.
Early Experience of the World’s First Single-Room Gantry Mounted Active Scanning Proton Therapy System at an Integrated Cancer Center
Authors: Forsthoefel Matthew , Ballew Elizabeth , Unger Keith R. , Ahn Peter H. , Rudra Sonali , Pang Dalong , Collins Sean P. , Dritschilo Anatoly , Harter K. William , Paudel Nitika , Collins Brian T. , Lischalk Jonathan W.
Published: February 2020

Introduction Review the early experience with a single-room gantry mounted active scanning proton therapy system implemented in the modern era. Materials and Methods All patients treated with proton beam radiotherapy (PBT) were enrolled in an institutional review board-approved patient registry. Proton beam radiotherapy was delivered with a 250 MeV gantry mounted synchrocyclotron in a single-room integrated facility within the pre-existing cancer center. Demographic data, cancer diagnoses, treatment technique, and geographic patterns were obtained for all patients. Treatment plans were evaluated for mixed modality therapy. Insurance approval data was collected for all patients treated with PBT. Results A total of 132 patients were treated with PBT between March 2018 and June 2019. The most common oncologic subsites treated included the central nervous system (22%), gastrointestinal tract (20%), and genitourinary tract (20%). The most common histologies treated included prostate adenocarcinoma (19%), non-small cell lung cancer (10%), primary CNS gliomas (8%), and esophageal cancer (8%). Rationale for PBT treatment included limitation of dose to adjacent critical organs at risk (67%), reirradiation (19%), and patient comorbidities (11%). Patients received at least one x-ray fraction delivered as prescribed (36%) or less commonly due to unplanned machine downtime (34%). Concurrent systemic therapy was administered to 57 patients (43%). Twenty-six patients (20%) were initially denied insurance coverage and required peer-to-peers (65%), written appeals (12%), secondary insurance approval (12%), and comparison x-ray to proton plans (8%) for subsequent approval. Proton beam radiotherapy approval required a median of 17 days from insurance submission. Conclusion Incorporation of PBT into our existing cancer center allowed for multidisciplinary oncologic treatment of a diverse population of patients. Insurance coverage for PBT presents as a significant hurdle and improvements are needed to provide more timely access to necessary oncologic care.
Liver X receptor inhibits the growth of hepatocellular carcinoma cells via regulating HULC/miR-134-5p/FOXM1 axis
Authors: Zhang Yan , He Jintao , Yang Teng , He Wenhui , Jiang Shan , Zhong Dan , Xu Zhizhen , Wei Quanfang , Shi Chunmong
Published: February 2020

Background Highly upregulated in liver cancer (HULC), the specifically overexpressed long non-coding RNA (lncRNA) in human hepatocellular carcinoma (HCC), can promote the growth and metastasis of HCC cells. Therefore, it will be benefit to HCC treatment by effectively downregulating HULC. Liver X receptor (LXR), a member of nuclear receptor superfamily, exerts anti-tumor effects on various human malignancies including HCC. However, it is unclear whether the anti-HCC function of LXR is involved in the regulation of HULC. Methods Quantitative real-time PCR and Western blot were used to separately examine RNA and protein levels in HCC cells. Cell counting kit-8 assay was used to detect the growth of HCC cells in vitro . Dual-luciferase reporter assays were performed to analyze the regulation of forkhead box M1 (FOXM1) by miR-134-5p and the regulation of miR-134-5p by HULC. Xenograft models were engaged to evaluate the growth of HCC cells in vivo . Results In this study, we found that activation of LXR could inhibit the growth of HCC cells by downregulating HULC. Mechanistically, LXR decreased HULC via suppressing its gene promoter activity. Moreover, HULC and FOXM1 were highly expressed while miR-134-5p was lowly expressed in HCC tissues, and the level of HULC was positively correlated with that of FOXM1 while negatively correlated with that of miR-134-5p. Additionally, miR-134-5p downregulated FOXM1 by targeting 3′-untranslated region (UTR) of its mRNA, and HULC upregulated FOXM1 and its downstream target molecule cyclin D1 through sequestrating miR-134-5p. Furthermore, activation of LXR increased miR-134-5p while decreased FOXM1 by reducing HULC in HCC cells. The in vivo experiments showed that activation of LXR repressed the growth of HCC xenografts, and decreased HULC, FOXM1 and cyclin D1 while increased miR-134-5p in the xenografts. Conclusions Our results for the first time reveal that LXR can inhibit the growth of HCC cells by regulating HULC/miR-134-5p/FOXM1 axis. The novel pathway LXR/HULC/miR-134-5p/FOXM1 may serve as a promising target in HCC treatment.
Identification of reliable reference genes for gene expression studies in maternal reproductive tissues and fetal tissues of pregnant cows
Authors: Cheng Lei , Yu Jie , Hu Xiuzhong , Xiang Min , Xia Yu , Tao Bifei , Du Xiaoyong , Wang Dingfa , Zhao Shuhong , Chen Hongbo
Published: February 2020

Background: The relationship between the conceptus and the maternal uterine environment is crucial for the successful establishment and maintenance of pregnancy in cattle. Gene expression analysis of the conceptus and maternal reproductive tissues is a favorable method to assess the embryonic maternal interaction. The reliability of the commonly used method reverse transcription-quantitative polymerase chain reaction (RT-qPCR) depends on proper normalization to stable reference genes (RGs). The objective of this study was to determine the expression stability of ten potential RGs (SUZ12, CNOT11, ACTB, RPL19, RPS9, GAPDH, TBP, HPRT1, SDHA and PPIA) in maternal reproductive tissues and fetal tissues, and to analyze the effect of RG selection on the calculation of the relative expression of target genes. Results: The expression stability of ten potential RGs was analyzed in eight different tissues (caruncular endometrium, intercaruncular endometrium, corpus luteum, ovary, oviduct, mammary gland, embryonic disc and trophoblast) from three pregnant dairy cows. Three programs—GeNorm, NormFinder and Bestkeeper—were used to identify the best RGs. According to all three programs, the most stable RG was CNOT11, whereas the least stable RGs were GAPDH and HPRT1. GeNorm analysis showed that a combination of five RGs (SDHA, PPIA, CNOT11, RPS9 and RPL19) was necessary for appropriate data normalization. However, NormFinder analysis indicated that the combination of CNOT11 and PPIA was the most suitable. When target genes were normalized to these RGs, the relative expression of the Radical S-adenosyl methionine domain containing 2 gene was not affected by the choice of RGs, whereas a large difference was observed in the expression profile of the Nuclear erythroid2-related factor 2 gene between the most stable RGs and least stable RGs. Conclusions: The results indicate that careful selection of RGs is crucial under different conditions, especially for target genes with relatively small fold changes. Furthermore, the results provide useful information for the selection of RGs for evaluating genes affecting bovine reproduction.
Fenofibrate Ameliorates Insulin Resistance of Lipoprotein Lipase Knockout Heterozygous Mice
Authors: Li Yangxue , Han Tingting , Zheng Shuang , Ren Xingxing , Hu Yaomin
Published: February 2020

Background The benefits of fenofibrate (FB), a peroxisome proliferator-activated receptor-a agonist, against hyperlipidemia have been established. We investigated the effect of fenofibrate on insulin resistance of lipoprotein lipase knockout heterozygous (LPL+/-) mice, which represent inherited hypertriglyceridemia and impaired glucose tolerance. Methods Male LPL+/- mice were treated with FB (50 mg/kg, once daily) via gavage for 8 weeks. Plasma lipid, glucose tolerance test, systemic insulin sensitivity, insulin signaling of tissues, genes and proteins related to endoplasmic reticulum (ER) stress and oxidative stress were analyzed. Results Body weight of 40-week LPL+/- with FB were reduced by 30.3% (P<0.05), while the differences of 16- and 28-week LPL+/- with FB were not significant (P>0.05). FB improved the lipid profile of both 28 and 40-week LPL+/- (P<0.001 for both), while that of 16-week LPL+/- mice with FB was unaltered (P>0.05). Glucose tolerance of 40-week LPL+/- were improved by FB (P<0.05), while that of 16- and 28-week LPL+/- with FB kept unaltered (P>0.05). Fasting insulin of 40-week LPL +/- were improved by FB (P<0.05), thus HOMA-IR of 40-week LPL+/- was declined (P<0.05). HOMA-IR of 16- and 28-week LPL+/- with FB had no change. Insulin-stimulated phosphorylated Akt (Ser473) in liver and skeletal muscle of 28-week LPL+/- was enhanced by FB (P < 0.001 and P<0.05 respectively). ER stress biomarkers were detected decreased in liver of 16- to 40-week LPL+/- with FB whereas that in muscle of LPL+/- with FB unchanged. Reduced reactive oxygen species (ROS) levels and augmented mRNA expression of superoxide dismutase (SOD) and catalase (CAT) in skeletal muscle of 28- and 40-week LPL+/- mice with FB were observed. There was no significance on ROS levels and mRNA of SOD and CAT in liver between LPL+/- mice with and without FB. Conclusions Fenofibrate improved lipid profile, glucose tolerance, systemic and tissue-specific insulin resistance of LPL knockout heterozygous mice. This may be associated with alleviated endoplasmic reticulum stress in liver and reduced oxidative stress in muscle.
Is Ankylosing Spondylitis a single disease? A clinical and genetic perspective
Authors: Laza Imanol Martín , Hervella Montserrat , Madrigal Juan Maria Blanco , Galíndez Eva , Rivera Natalia Andrea , Vivar Maria Luz Garcia , de-la-Rúa Concepción
Published: February 2020

Background:The aim of the present study was to evaluate whether ankylosing spondylitis (AS) and non-radiographic axial spondyloartritis (nr-axSpA) are subsets of a single disease from a genetic perspective. Methods:We analyzed from a clinical and genetic perspective 62 patients from the University Hospital of Basurto (Bilbao, Spain) diagnosed with axial spondyloarthritis. Forty three SNPs previously associated with spondyloarthritis (SpA) were selected. The DNA samples were genotyped through SNP Type Assay, using the BioMark HD platform of Fluidigm. Results:Regarding clinical characteristic we found statistically significant differences between the patients with AS and nr-axSpA in the age at diagnosis, the disease duration, the presence of syndesmophytes and the BASMI index. In relation to genetic markers, we only found statistically significant differences in HLA-B27 allele frequency between the two groups. Regarding the frequencies of the SNPs, no statistically significant differences were found between the two groups. Despite the high genetic heterogeneity observed among the patients, it is worth highlighting that some of the most important risk SNPs associated with AS, located in genes (ERAP1, ERAP2, IL-23R, GPR25) and intergenic region (2p15), appeared at high frequencies in all the patients.Conclusion:We have observed that AS and nr-axSpA have a common genetic background associated with the pathogenic development of these diseases; therefore, we suggest that the two entities constitute two different expressions of the same disease. Among the genetic factors, the present study shows the importance of genes involved in the pathogenesis of AS, such as HLA-B27, ERAP1, ERAP2, IL-23R, GPR25 and intergenic region 2p15, whose role may influence the onset, development and severity of the disease. However, the pathogenesis of SpA is very complex, indicating the involvement of environmental factors (smoking and obesity), in the triggering of the disease, so that patients with different genotypes would have the same pathogenic phenotype.
COMPARATIVE ANALYSIS OF FINANCIAL TECHNOLOGY REGULATION SYSTEMS: FOREIGN AND DOMESTIC EXPERIENCE
Authors: Semynoh A. , Bukhtiarova A. , Bort N.
Published: February 2020

In the article, based on the analysis of scientific sources, a comparative analysis of financial market regulation systems in different countries of the world is made. The level of development of regulatory systems in the UK, France, USA, India and Ukraine is characterized. The main institutions that regulate and supervise in the countries of the world are listed. The basic principles of their functioning are presented. It also analyzes the regulatory and provisions governing the activities of fintech companies. It is determined that a particular problem for the development of the financial technology market is the lack of a single regulatory approach to different types of Fintech companies and solutions. This is evidenced by the lack of unified regulatory bodies in the field of fintech, as well as adequate regulatory support both in Ukraine and in foreign countries.
At the moment, in most countries of the world, fintech companies are subject to the laws that were adopted in the times of existence of only classical financial institutions, and therefore do not take into account the specifics of individual fintech businesses, and their peculiarities of cooperation with banking and non-banking financial institutions, with intermediaries of the securities market. It is determined that, in accordance with the potential of the financial technology market development and the benefits of its growth, programs for the support and development of the financial market through the introduction of special commissions, accelerator funds and simplified regulation systems in the form of sandbox fintech are being implemented in all analyzed countries. It is determined that the driver of the growth of fintech solutions in the financial services market was the active dissemination of open APIs in the activities of financial institutions, which provide for voluntary exchange of information about bank customers with fintech companies. It is substantiated that an important component of increasing confidence in the financial technology market is ensuring the storage and protection of personal data of fintech companies’ clients.
Keywords:
financial technology market, fintech, financial services, financial institutions, financial technology market regulation system.
Cristianismo ou conservadorismo? O caso do movimento anti-aborto no Brasil
Authors: Rocha Camila
Published: February 2020

O objetivo deste artigo é interpretar atuação do movimento anti-aborto no Brasil ressaltando seu caráter conservador em detrimento de sua caracterização como um movimento cristão ou anti-secular. O movimento anti-aborto teria surgido após a redemocratização como um contra-movimento em oposição ao avanço do movimento feminista, passando a realizar posteriormente inúmeras disputas relacionadas a pautas feministas, LGBT, e relacionadas à defesa de direitos humanos no legislativo, no judiciário e em protestos e demonstrações públicas. O argumento principal desenvolvido neste artigo, a partir da revisão da literatura especializada e reunião de informações relacionadas aos atores políticos envolvidos no embate em torno da questão do aborto, é de que a atuação como movimento social, e não apenas com base na atuação de padres, missionários e bispos,  fez com que fosse possível para os ativistas anti-aborto aglutinar em torno de um mesmo discurso pessoas conservadoras que simplesmente se identificassem com suas pautas independentemente de sua confissão religiosa, e para tanto mobilizam fundamentalmente argumentos seculares.
Modulatory Nano/Micro Effects of Diabetes Development on Pharmacology of Primary and Secondary Bile Acids Concentrations
Authors: Mooranian Armin , Zamani Nassim , Takechi Ryu , Luna Giuseppe , Mikov Momir , Goločorbin-Kon Svetlana , Kovacevic Bozica , Arfuso Frank , Al-Salami Hani
Published: February 2020

Background:

Recent studies have suggested that hyperglycaemia influences the bile acid
profile and concentrations of secondary bile acids in the gut.

Introduction:

This study aimed to measure changes in the bile acid profile in the gut, tissues, and faeces
in type 1 Diabetes (T1D) and Type 2 Diabetes (T2D).

Method:

T1D and T2D were established in a mouse model. Twenty-one seven-weeks old balb/c mice
were randomly divided into three equal groups, healthy, T1D and T2D. Blood, tissue, urine and faeces
samples were collected for bile acid measurements.

Results:

Compared with healthy mice, T1D and T2D mice showed lower levels of the primary bile
acid, chenodeoxycholic acid, in the plasma, intestine, and brain, and higher levels of the secondary bile
acid, lithocholic acid, in the plasma and pancreas. Levels of the bile acid ursodeoxycholic acid were
undetected in healthy mice but were found to be elevated in T1D and T2D mice.

Conclusion:

Bile acid profiles in other organs were variably influenced by T1D and T2D development,
which suggests similarity in effects of T1D and T2D on the bile acid profile, but these effects were not
always consistent among all organs, possibly since feedback mechanisms controlling enterohepatic recirculation
and bile acid profiles and biotransformation are different in T1D and T2D.
Mental Health Literacy: A Strategy for Global Adolescent Mental Health Promotion
Authors: Clauss-Ehlers Caroline S. , Carpio Maria Guevara , Weist Mark D.
Published: February 2020

Background:

Adolescence is defined by key transitional elements which are considered
within a cross-cultural context. The importance of building mental health capacity for
adolescents in low- and middle-income countries (LMICs) as well as high-income countries
(HICs) is reviewed.

Objectives:

To review the developmental period of adolescence, global needs for mental
health promotion, the needs of LMICs while emphasizing building adolescent mental health
capacity, and the importance of efforts to promote mental health literacy.

Methods:

Mental health literacy (MHL) is presented as a strategy that can increase public
awareness regarding mental health issues among adolescents. Increased awareness through
an MHL framework is discussed as a way to build adolescent mental health capacity; with
this work ideally occurring through global communities of practice (COP), dialogue, collaboration,
and mutual support that aim to build innovation in systems of mental health promotion.

Results:

The authors review structural components in research, practice, and policy that seek
to build global adolescent mental health capacity, nested within COPs involving HICs and
LMICs working together to advance mental health promotion for children, adolescents, and
young people.

Conclusion:

The article concludes with a discussion of how the three structural components
(i.e., research, practice, and policy) can address gaps in the provision of global mental health
services for adolescents to meet adolescent mental health needs in LMICs and HICs. A
multi-sectoral approach emphasizing a global COP is presented as a way to scale up capacity
and maximize outcomes.
Turn back plagiarism! Budaya Organisasi Anti Plagiarism
Authors: Isnaini Rohmatun Lukluk
Published: February 2020

Penelitian ini bertujuan untuk mengetahui budaya organisasi antiplagiarisme di pascasarjana UIN Sunan Kalijaga Yogyakarta. Metode penelitian yang digunakan adalah penelitian kualitatif. Data diperoleh melalui wawancara, observasi, dan dokumentasi. Hasil penelitian menyebutkan pascasarjana di UIN Sunan Kalijaga Yogyakarta telah menegakkan budaya organisasi antiplagiarisme melalui 3 hal, yaitu artefak, espoused value/ enacted behavior dan asumsi dasar yang dipercaya. Artefak antiplagiarisme ditunjukkan pada stiker dan tempelan dinding yang berisi redaksi penolakan tindakan plagiarism yang dipasang ditempet-tempat strategis. Espoused value/ enacted behavior ditunjukkan melalui penyusunan student handbook dan pemberlakuan checker plagiarism pada karya tulis mahasiswa. Adapun tingkatan tertinggi pada budaya organisasi adalah asumsi yang menjadi dasar nilai antiplagiarisme adalah nilai-nilai penjabaran pancasila yang sangat menjunjung tinggi Hak Kekayaan Intelektual (HAKI).Kata kunci: plagiarisme, antiplagiarisme, budaya organisasiTurn back plagiarism! Anti plagiarism organizational cultureAbstractThis research aims to determine the organizational culture of antiplagiarism in the postgraduate UIN Sunan Kalijaga Yogyakarta. The research method used is qualitative research. Data obtained through interviews, observation, and documentation. The results of the study state that postgraduate programs at UIN Sunan Kalijaga Yogyakarta have upheld antiplagiarism organizational culture through 3 things, namely artifacts, espoused value / enacted behavior and trusted basic assumptions. Antiplagiarism artifacts are shown on stickers and wall patches containing editorial rejection of plagiarism actions placed in strategic locations. Espoused value / enacted behavior was demonstrated through the preparation of the student handbook and the application of plagiarism checkers in student papers. The highest level in organizational culture is the assumption that is the basis of the value of antiplagiarism is the translation values of Pancasila that highly uphold Intellectual Property Rights (IPR).Keywords: plagiarism, antiplagiarism, organizational culture
Dampak perceraian orang tua terhadap perkembangan psikososial dan prestasi belajar
Authors: Mone Harry Ferdinand
Published: February 2020

Tujuan yang dicapai pada penelitan ini mendeskripsikan: 1.) Dampak perceraian orang tua terhadap perkembangan psikososial anak; 2.) Dampak perceraian orang tua terhadap prestasi belajar anak; 3.) Langkah-langkah pemulihan perkembangan psikososial anak akibat perceraian orang tua; dan 4) langkah-langkah pemulihan prestasi belajar anak akibat perceraian orang tua. Penelitian ini berlokasi di kecamatan Oebobo, kota Kupang. Penelitian ini menggunakan pendekatan fenomenologi dengan menggunakan metode kualitatif deskriptif. Subjek dalam penelitian ini adalah pasangan yang bercerai dengan orang, keluarga, tetangga, anak, dan guru wali kelas, yang berjumlah 35 orang. Hasil penelitian yang diperoleh: 1.) Perceraian (cerai hidup) membawa dampak yang negatif terhadap perkembangan psikososial dan prestasi belajar anak; 2.) Emosi atau perasaan anak sangat mempengaruhi aktivitas belajar di sekolah maupun di rumah, baik perasaan sedih, gembira, aman, marah, cemas, takut dan lain sebagainya; 3.) Adanya komunikasi antara orang tua dan anak setelah bercerai memperkecil pengaruh negatif dari perceraian. Kasih sayang dari keluarga kedua belah pihak dan bantuan guru dalam mengasuh anak korban perceraian di rumah dan sekolah, membuat anak kuat dan tegar menghadapi masalah keluarganya; dan 4.) Langkah pemulihan prestasi belajar yakni bersifat mendidik, misalnya memberikan pujian, hadiah, dan lain sebagainya yang mengandung nilai edukatif. AbstractThe objectives achieved on this research describe: 1.) The impact of divorce of parents to the psychosocial development of children; 2.) The impact of divorce of parents on children's learning achievement; 3.) The measures of recovery of child psychosocial development due to divorce Parents; and 4.) The steps of recovering children's learning achievement due to parents ' divorce. Research data and located in Oebobo sub-district Kupang. This study uses phenomenological approaches using qualitative descriptive methods. The subject in this study was a couple who divorced people, a family, a neighbor, the child, and a homeroom teacher, whom It amounted to 35 people. Results of research obtained; Divorce (divorced) carries a negative impact on psychosocial development and child learning achievement. Emotions or feelings of children significantly affect the learning activities at school or home, whether feeling sad, joyful, safe, angry, anxious, afraid, and so on. The communication between parents and children after divorce minimized the negative influence of divorce. The affection of the family both sides and the help of teachers in caring for the child's divorce victims at home and school, making the child active and rigid facing his family problem. The steps of learning achievement are educational, such as giving praise, gifts, and others that contain an educative value.
A Study on Environmental Sound of Tourist Attraction by Sound Level Meter: Busan Ocean Festival in Korea
Authors: Shin Limsoo
Published: February 2020

The environmental sound from festival tourist attractions at Haeundae and Gwangalli in Korea was measured and ascertained exposured environments to constant noise by comparing with precedent researches, the law of execution and demonstration, and conditions of festival sites. Noise sound from array speakers for the main stage at Ocean festival in Busan determined not only differences in accordance with distance such as 0, 1, 5, 10, 15, and 20 meters from the speakers but also station coordinate and altitude were used by an application program. As a result, measured noise before and after sunset showed meaningful difference (p < 0.05) and a station 20 meters away reported as the loudest level in Haeundae case. Noise level difference by distance from sound sources before sunset was significantly existed (p < 0.05). Otherwise, it significantly recorded different noise levels between before and after sunset in Gwangalli tourist attraction (p < 0.05). The noise level of farther station (20 m) was the lowest before sunset and noise level by distance statistically was significant (p < 0.05). In conclusion, Gwangalli tourist attraction generally had bigger noise sound than Haeundae’s. Flying array speakers could make the sound measurement different by studying advanced research and temperature would also influence on the noise level between day and night times.
THE EFFECTS OF PHALERIA MACROCARPA EXTRACT ON MITOTIC INDEX AND TUMOR MASS PROGRESSION OF EPIDERMOID CARCINOMA IN SWISS MICE: IN VIVO EXPERIMENTAL STUDY IN SWISS MICE TREATED WITH NEOADJUVANT PACLITAXEL AND CISPLATIN
Authors: VITO MAHENDRA EKASAPUTRA  , MUHAMAD THOHAR ARIFIN  , DJOKO HANDOJO
Published: February 2020

Objectives: Polyphenols in Phaleria macrocarpa (mahkota dewa) can inhibit mitogen-activated protein kinase activity in receptor tyrosine kinases pathway. This can be recognized from the decrease of mitotic index as a response to malignant cells and the reduction of tumor development. This study aimed to determine whether P. macrocarpa may decrease the mitotic index and tumor diameter in epidermoid carcinoma.

Methods: The experiment was conducted on 18 epidermoid carcinoma induced Swiss mice divided into four groups: Control, Phaleria administered (0.0715 mg [0.36 ml]/day), chemotherapy administered (paclitaxel 175 mg/m2 and cisplatin 50 mg/m2), and combination group. Tumor size diameter was measured before and after treatment in 9 weeks. Mitotic index was measured at the end of the treatment.

Results: There were significant differences in the mitotic index and changes in tumor diameter among groups compared with the control group. The most significant growth inhibition and decrease in mitotic index were in group four. There was a significant positive correlation between tumor mitotic index and changes in tumor diameter (r=0.813).

Conclusion: P. macrocarpa is able to decrease tumor cells’ mitotic index and inhibit epidermoid carcinoma’s tumor mass progression in Swiss mice.
BIOGENIC SELENIUM NANOPARTICLES FOR THEIR THERAPEUTIC APPLICATION
Authors: AWANISH KUMAR  , KUMAR SURANJIT PRASAD
Published: February 2020

Biosynthesis is an eloquent, safe, biocompatible, eco-friendly, and recyclable way of preparing selenium nanoparticles (SeNPs). Selenium occurs in multiple oxidation states, for example, +6, +4, 0, or −2. Selenium (Se) is an essential trace element with a very narrow margin between the lowest acceptable levels of intake and toxicity. Selenium is an essential trace element required for all living organisms. Despite its essentiality, selenium is a potentially toxic element to natural ecosystems due to its bioaccumulation potential that is why it is biologically available in the environment. Selenium is a trace element commonly found in materials of the earth’s crust, and it is essential for humans, animals, and plants. Oxyanions of selenium, that is selenite and selenate, are biologically available. Selenium in the form of selenate ion (SeO42−) is more toxic to most organisms than selenite (SeO32−). Contrarily, elemental selenium (Se0) is inOsoluble and less toxic in comparison to other forms of selenium. Nanoselenium (Se0) in the range of 100–500 nm has similar bioavailability to other forms of selenium into plants, animals, humans, and microorganisms. Biologically synthesized SeNP has many biological applications in the field of medical and pharmaceutical research to combat threats to human health. Biogenic SeNPs have anticancer (cytotoxic) activity, antioxidant activity, and antimicrobial activity. Researches are going on with special interest of SeNPs. Conjugation of antibiotics with SeNPs enhances their anticancer efficacy. SeNPs have also applications in nanobiosensors and environmental remediation.
STUDY OF ANTIBACTERIAL AND ANTIFUNGAL EFFECT OF THE ESSENTIAL OILS OF CHENOPODIUM AMBROSIOIDES L. AND ROSMARINUS OFFICINALIS L.
Authors: MAMMAD ZINEB  , TORMAL DJASSINRA  , KRIBII ABDERAHIM  , OUNINE KHADIJA
Published: February 2020

Objective: This work looks at the valuation of two medicinal plants growing wild in the region of Gharb (Chenopodium ambrosioides L. and Rosmarinus officinalis L.) through the study of their antibacterial and antifungal effects vis-à-vis Xanthomonas fragariae, Pseudomonas aeruginosa, Staphylococcus aureus, and two fungal strains; Fusarium solani and Botrytis cinerea.

Methods: The extraction of essential oils from each plant was carried out by hydrodistillation in a Clevenger-type apparatus. The antibacterial and antifungal tests of essential oils are carried out according to the method of diffusion using sterile discs (or aromatograms). Results are expressed in inhibition areas.

Results: Antibacterial activity of essential oil of R. officinalis L. is best compared to that of C. ambrosioides L. with an area of inhibition that is shared by 1661.06 and 1384.74, respectively, for bacteria X. fragariae and P. aeruginosa, while this area is between 2122.64 and 2826 mm2 for F. solani and B. cinerea. Moreover, the essential oils of these two plants by the method of disk diffusion feature a very significant inhibitory effect on X. fragariae and P. aeruginosa, whereas they have no effect on S. aureus.

Conclusion: The essential oils of C. ambrosioides L. and R. officinalis L. could be used as preservatives in food, to protect them from microbial or fungal spoilage.
SPECTROFLUORIMETRIC DETERMINATION OF EOSIN CHEMILUMINESCENCE SYSTEM FOR THE ANALYSIS OF DABIGATRAN IN PHARMACEUTICAL FORMULATIONS
Authors: DHANAPAL Y  , SRUDHIVINOD V  , MOHAMAD WASEEM A
Published: February 2020

Objectives: The objectives of this study were to develop a rapid, simple, and economical spectrofluorometric method for quantification of dabigatran from marketed formulation and its principle involved based on the protonated process of a binary mixture complex formation with eosin Y.

Methods: A simple and precise spectrofluorometric technique was applied for the method development. It depends on measuring the quenching effect of the drug on the native fluorescence of eosin at excitation under the optimum reaction conditions.

Results: The reaction linear calibration graph constructed between the fluorescence quenching valves flouresence intensity (ΔF) and the concentration ranges of 5–50 μg/ml. Spectrofluorometric analytical performance was validated by accuracy, precision, and specificity, and the results were satisfactory.

Conclusion: This method was to develop a fast, simple, and economically applied successfully for the assay, and qualification of dabigatran tablet contains drug, also with different coformulated pharmaceutical formulations.
STUDY OF TUMOR MICROENVIRONMENT AND HOST RESPONSE IN COLORECTAL CANCER: IMMUNOHISTOCHEMICAL AND CLINICOPATHOLOGICAL APPROACH
Authors: NORIA OTHMAN RAFFALLA  , SUZAN MOHAMED FAROUK HELAL  , AMANY ABD EL-BARY ABD EL-LATIF  , RASHA OMAR ELSAKA
Published: February 2020

Objective: This study aimed to evaluate the immunohistochemical expression of forkhead boxP3 (Foxp3), CD8, CD68, and CD21 in stroma between tumor cells of colorectal cancer (CRC) patients and examines the relationship between these variables and clinicopathological parameter and patients’ prognosis.

Methods: In this work, 50 cases of colorectal carcinomas were included and immunohistochemical evaluation of Foxp3, CD8, CD68, and CD21 in tumor tissue samples.

Results: Tumor-infiltrating lymphocytes (TILs) including cytotoxic T cells and regulatory T cells as well as tumor-associated macrophages and follicular dendritic cells (FDCs) were studied in the stroma of the tumor using immunostaining technique for CD8, Foxp3, CD68, and CD21, respectively. Cases were followed up. CD8-positive cytotoxic T cells, Foxp3-positive regulatory T cells, and CD21 positive-FDCs were significantly more pronounced in early tumors and those with longer overall survival. On the other hand, CD68 positive macrophages were more encountered in late stage and metastatic tumors as well as tumors with shorter overall survival, but these results not reached the level of significance.

Conclusion: We concluded that (TILs) and FDCs are conferring better prognosis in CRCs, they may act synergistically in stimulating a protective immune response in the tumor microenvironment that hinders tumor progression, while the role of tumor-associated macrophages in CRCs is still controversial and needs further studies.
OBESITY AS A COMMON COMORBIDITY IN PATIENTS WITH DIABETES: OCCURRENCE BASED ON EATING HABITS AND OTHER DETERMINANTS IN WEST JAVA, INDONESIA
Authors: SUHARTATIK MELIZA , DEWI SARTIKA RATU AYU
Published: February 2020

Objective: The prevalence of obesity in individuals with diabetes mellitus (DM) is fairly high. It has been shown that obesity worsens insulin resistance and can elevate the risk for complications of diabetes. Therefore, this study aimed to assess the prevalence of obesity and to determine the factors that affect obesity in adults with DM.

Methods: This study used a cross-sectional design and included secondary data from the “Cohort Study of Risk Factors for Non-communicable Diseases.” The study was conducted on adults with DM at Kebon Kelapa Village, West Java, in 2017, and the total sample obtained for analysis was 112 respondents.

Results: In this study, 62.5% of adults with DM were overweight or obese (body mass index ≥25 kg/m2). Factors found to influence the incidence of obesity in adults with DM were sex and macronutrient intakes, namely, “over” energy intake, “over” carbohydrate intake, “over” fat intake, and “normal” protein intake. Risk of obesity was 3.15-fold higher in female than male participants with diabetes. The highest risk for increased obesity level in adults with diabetes was found in those with “over” fat intake (odds ratio, 8.33).

Conclusions: In adults with diabetes, the incidence of obesity is a trigger of complications. Therefore, to improve the quality of life of individuals with diabetes, attention must be given to managing their weight.