bluuebunny/crossref_metadata_2025 huggingface dataset:
Developing strategies to enhance patient adherence to prescribed treatment regimens
Authors: Akosua Dufie Amofah  , Jehu Narh Apaflo  , Jemima Adwoa Misszento
Published: December 2024

Treatment adherence in the US healthcare system is still a problem. This manuscript presents a detailed discussion of the status quo regarding challenges, strategies, and future directions to improve adherence. Adherence to treatment regimens is influenced by a number of patient and treatment-related factors, as well as socioeconomic status and issues within the healthcare system. These challenges have been addressed over the years with educational, behavioral, policy-based, and technological interventions. These ongoing challenges can only be addressed with innovative strategies as healthcare is evolving. Digital health tools and culturally tailored materials included in personalized education programs have been found to improve adherence rates compared to standard care. In addition, patients have been recommended to be motivated through collaboration with healthcare providers in community outreach initiatives, and adherence has been improved. This review does a comprehensive summary of the key issues and trends in patient adherence, shedding light on the important work for healthcare professionals, researchers and policymakers to improve adherence and health outcomes in the United States.
Forecasting currency exchange rates using EMD-ARIMA Model
Authors: Dennis Cheruiyot Kiplangat
Published: December 2024

In today’s global economy, accuracy in forecasting currency exchange rates is of much importance to any future investment. Currency exchange rates portray non-linear and non-stationary characteristics hence to address these characteristics; this paper proposes a hybrid forecasting model using the Empirical Mode Decomposition (EMD) technique, and the ARIMA model. EMD is used to decompose the raw currency exchange rate data into several intrinsic mode functions and one residual. The process of extracting the IMFs from the data is called the sifting process. EMD was used to detect the moving trend of currency exchange rate data and improve the forecasting success of the ARIMA model. The data were obtained from the Central Bank of Kenya website between the periods January 2005 to May 2017. The best ARIMA model fitted to the raw data before decomposition based on information criterion statistics was found to be ARIMA (1,0,3) for the KShs/AE. Dirham, ARIMA (1,0,1) for KShs/Australian dollar and ARIMA (1,0,3) for KShs/Canadian dollar currency exchange rates. After forecasting, we then compared the forecasted values with the actual data to check the suitability of the ARIMA model. Further, EMD was applied to the exchange rate data and then fitted an ARIMA model to the IMFs. The best model was found to be ARIMA (1,0,1) for the KShs/AE. Dirham, ARIMA (0,0,1) for KShs/Australian dollar and ARIMA (1,0,1) for KShs/Canadian dollar currency exchange rates. The appropriateness of these models was tested using the Ljung-Box test. The forecasting performance of each model was evaluated using the RMSE.
Comparative Study of the proximate composition and antioxidant capacity of processed Corchorus olitorius
Authors: Patience Abidemi Omololu  , Victor Olusola Omololu  , Ayosunkanmi Temitope Ogunrinde  , Anuoluwapo Olanrewaju
Published: December 2024

Corchorus olitorius is globally used both as a vegetable and as herb for medical and therapeutic purposes. The aim of this study was to evaluate the effect of different processing techniques (air drying- AD, oven drying- OD and sun drying- SD) on the antioxidant activity and proximate composition of Corchorus olitorius.
The moisture content of C. olitorius was significantly higher in SD and OD drying methods and was also significantly lower in AD when compared to other drying method. There is a significant increase in the carbohydrate level and ash content in the air-dried processed C. olitorius. All the other nutrients including crude protein and fats show that temperature conditions in oven drying, sun drying and air drying had no substantial effect on its retention.
Highest 2, 2-diphenyl-2-picryl-hydrazyl free radical scavenging activity (DPPH %) and Ferric reducing antioxidant power (FRAP) value retention were observed in air drying and lowest in oven drying.
The proximate composition and antioxidant activity of C. olitorius were found to be significantly higher (p < 0.05) in AD compared to OD and SD. The study concluded that AD should be considered an appropriate drying procedure for retaining excellent nutritive qualities and antioxidant capacity of Corchorus olitorius.
Modelling selected stock prices at the Nairobi securities exchange using Markov chains
Authors: Dennis Cheruiyot Kiplangat
Published: December 2024

This paper modelled four stock prices traded at the Nairobi stock exchange using Markov Chains. Markov chain is a stochastic process that has a Markovian property. The study focused primarily on the application of Markov Chain in analysing Nairobi Securities Market daily returns to describe the distribution of the market returns, cross-checking if a current market return depends on its preceding market returns and using the analysis to predict the future returns. Discrete Markov Chains were fitted to determine the probability of change of states in the returns of stock prices and to determine the extent to which the Markov model can be used to forecast returns. The idea of using Markov chains to predict the behaviour of market prices is widely used since prospective stock investors are concerned with stock price movements which might lead to an optimum investment strategy. The Markovian test carried out in the study on the daily returns showed that the returns had a Markov property. The model predicted that the share prices would either decrease to a range of minimum and lower average, decrease to a range of lower average and zero, remain unchanged, increase to a range of zero and upper average and increase to a range of upper average. The steady-state was found in the 21st, 23rd, 12th and 21st trading days for Centum, Equity Bank, East African Breweries Limited (EABL) and Kenya Airways respectively.
Exploring maternal parity and the feasibility of childbirth in space: Insights from terrestrial and extraterrestrial research
Authors: Elnaz Ghaffari
Published: December 2024

This comprehensive study, led by Ghaffari, explores the relationship between parity and various maternal health outcomes by analyzing 260 maternal death cases across Iran over a three-year period. The research, pioneering in its focus on astronaut-mothers, examines the association of parity with factors such as prolonged labor, rapid labor, induction rates, retained placenta, placental curettage, peripartum cardiomyopathy, vaginal bleeding, postnatal wellness, and maternal mortality. Methodologically, the study conducts a thorough statistical analysis of these parameters, aiming to identify patterns that may inform astronaut selection criteria for future space missions involving childbirth. Despite finding no significant correlation between parity and maternal health outcomes, the study underscores the need for further research on parity-specific differences, as current literature often amalgamates data for multiparous women. This research provides pivotal insights for advancing maternal health considerations in the unique context of space exploration.
The health work of Capodistrias – historical retrospection of the work and organization of the health care management of the newly established Greek state by its first governor
Authors: Chrysochoou Panagiota  , Tsiapourlianos K. Panagiotis  , Fotinou E Maria-Effrosyni  , Tagarakis A. Ioannis
Published: December 2024

The present paper aimed to collect and highlight one aspect of the work of Ioannis Capodistrias in an area that has been little explored, the healthcare planning of the newly established Greek state. An overwhelming percentage of the literature referring to the multifaceted personality of Ioannis Capodistrias studies
His activity in Italy where he studied Medicine and came into contact with modern knowledge, new ideas and trends,
His work as a doctor upon his return to Corfu after the end of his studies,
His activity in the political arena of the newly established State of the Ionian Islands,
His later life in Russia and then his activity as a diplomat and as Minister of Foreign Affairs of Russia,
His role in the struggle for National rebirth and finally,
His work as the first Governor of Greece.
His achievements in the European diplomatic arena and his contribution to key issues (such as the Swiss and French issues) aiming at peace on the European continent, his vision for a free Ionian state at the beginning of his diplomatic career and a free Greek state thereafter, are able to give a global picture to the modern scholar of the dynamics of Ioannis Capodistrias as the multifaceted personality he was. The assignment of the governance of the newly established Greek state to Ioannis Capodistrias set the newly established Greek state, impoverished by the war, on a path of development that could stand in Europe together with the important powers of Epirus. However, his assassination violently halted this dynamic of development, constituting in essence the murder of the newly established state of Greece.
Cultural hybridity and the black diaspora: Representations in contemporary African and African-American narratives
Authors: Tolulope Daniel Ojuola
Published: December 2024

Cultural hybridity stands as a defining characteristic of Black diasporic literature, reflecting the intricate blending of African and Western traditions in the lived experiences of African and African-American communities. This study examines the representation of cultural hybridity in contemporary African and African-American narratives, with a particular focus on its role in shaping complex Black identities. By analyzing novels such as Teju Cole's Open City and Yaa Gyasi’s Homegoing, the paper explores how literature navigates the tensions between ancestral heritage and modernity, community and individuality, and belonging and alienation. Teju Cole’s Open City presents a protagonist grappling with the layered nuances of identity, tracing the intersections of race, class, and global migration. In contrast, Yaa Gyasi’s Homegoing explores generational trauma and cultural continuity, connecting African roots to the fragmented histories of descendants scattered across the diaspora. These works highlight how hybridity serves not only as a site of conflict but also as a source of strength and renewal, enabling characters to embrace multifaceted identities. Through themes such as dual identities, displacement, and cultural negotiation, this paper reveals how Black diasporic literature serves as a lens to explore the fluidity of identity. The study argues that cultural hybridity is not merely a consequence of colonialism or migration but an evolving force that redefines what it means to be African or African-American in a globalized world. Ultimately, these narratives challenge rigid notions of identity, offering a rich tapestry of voices that affirm the resilience and creativity of the Black diaspora.
Efficacy of a protein-micronutrient dietary supplement in preschool children with acute malnutrition: A randomized controlled clinical trial
Authors: Pranit Yadaw Ambulkar  , Bhagwat Chandrakant Tambe  , Prabhakar Ramachandra Jadhav
Published: December 2024

Malnutrition remains a critical health challenge among children in both rural and urban regions of India. While financial constraints play a role, the predominant contributing factor is a lack of awareness regarding individual nutritional needs and appropriate strategies to address them. Efforts by organizations such as the WHO, government bodies, medical institutions, and social workers aim to mitigate this widespread issue. This study evaluates the efficacy of Naturamore for Kids, a protein-multivitamin-nootropic supplement, in managing acute mild and moderate malnutrition in 370 preschool children aged 2 to 6 years over a three-month intervention.
The results demonstrated statistically significant improvements in anthropometric parameters within the trial group compared to the control group, which received milk and traditional nutritional remedies. Height increased by 3.06% in the trial group versus 2.34% in the control group, while weight increased by 9.08% in the trial group compared to -6.31% in the control group (p < 0.001). The superior outcomes may be attributed to the formulation's optimized blend of proteins (whey, soy, rice, and peas), fortified vitamins and microminerals, and herbal nootropics such as Ashwagandha and Brahmi. These findings highlight the potential of Naturamore for Kids as an effective intervention for improving growth and nutritional status in malnourished preschool children.
The effect of leadership style on employee motivation: A case study of Hormuud telecom in Somalia
Authors: Sadia Abdulkadir Ibrahim  , Aylin Erdoğdu
Published: December 2024

The research is used to investigate the effect of leadership style on employee motivation in homuud telecom somalia, the main objects of this study is used to discover, To study the prevalent leadership styles practiced at Hormuud Telecom, How do these leadership styles affect employee motivation and job satisfaction, and how strategies can be implemented to enhance leadership effectiveness and employee motivation. For the research, a quantitative approach was utilized, and the sample size consisted of 140 individuals. The data was gathered through the use of a questionnaire. this study was conducted in spss, and the data analysis was utilized. The questionnaire based the independent variable of transformational leadership and transactional leadership and dependent variable of productivity level of the study
Corporate Social Responsibility (CSR) And Brand Image
Authors: Jinyoung Hwang
Published: December 2024

This study provides a thorough analysis of the relationship that exists between brand image and CSR. By combining existing knowledge, examining empirical data, and providing insights into the possible consequences and uses for organizations, this research seeks to shed light on this complex relationship. The objective is to undertake a comprehensive examination of the extant scholarly literature pertaining to CSR and its impact on brand image. In this research, a mixed-methods research approach was applied to completely study the relationship between CSR and brand image. The research design combined both qualitative and quantitative methodologies, providing for a holistic knowledge of the CSR-brand image nexus. Findings indicate that within the ever-changing and dynamic realm of business, CSR has developed as a strategic instrument for the purpose of defining brand image and cultivating consumer loyalty. Consumers are not solely in pursuit of items; rather, they are making deliberate decisions to associate themselves with brands that are in harmony with their personal beliefs. Consequently, businesses must prioritize the establishment of authentic and transparent CSR activities. The alignment between the ethical compass that guides CSR actions and the basic principles of a corporation is crucial. Overall, this research has provided evidence to support the notion that CSR--+ has transitioned from being a discretionary choice to being an essential requirement in contemporary society.
Leveraging geographic information systems and data analytics for enhanced public sector decision-making and urban planning
Authors: Rita Uchenna Attah  , Baalah Matthew Patrick Garba  , Ifechukwu Gil-Ozoudeh  , Obinna Iwuanyanwu
Published: December 2024

Geographic Information Systems (GIS) and data analytics are revolutionizing public sector governance and urban planning by providing innovative tools for data-driven decision-making. This review explores the integration of GIS and data analytics as a means to address complex challenges in resource management, crisis response, environmental sustainability, and urban development. GIS enables spatial data collection, visualization, and analysis, while advanced data analytics, including predictive models and machine learning, enriches decision-making processes by uncovering actionable insights from diverse datasets. Applications in public governance include optimizing resource allocation, enhancing emergency response strategies, and managing environmental impacts. In urban planning, GIS facilitates land use management, infrastructure development, and the creation of smart cities powered by the Internet of Things (IoT). The review highlights successful case studies, showcasing how cities worldwide have leveraged these technologies to achieve sustainable development and improve the quality of life for their residents. Despite their potential, the implementation of GIS and data analytics faces challenges such as data quality issues, financial and technical constraints, privacy concerns, and resistance to change within bureaucratic systems. This review discusses these barriers and offers insights into overcoming them through advancements in technology, collaborative governance models, and increased stakeholder engagement. This concludes by emphasizing the transformative role of GIS and data analytics in fostering more transparent, efficient, and sustainable urban governance. By embracing these tools, public sector entities can better anticipate and address societal needs, paving the way for more resilient and inclusive communities. Future opportunities include leveraging artificial intelligence, expanding GIS use cases, and fostering international collaboration to further enhance public sector and urban planning outcomes.
Optimizing procurement efficiency: Frameworks for data-driven cost reduction and strategic vendor management
Authors: Iyadunni Adewola Olaleye  , Chukwunweike Mokogwu  , Amarachi Queen Olufemi-Phillips  , Titilope Tosin Adewale
Published: December 2024

This paper explores data-driven frameworks for optimizing procurement efficiency, focusing on cost reduction strategies and strategic vendor management. Procurement is critical in enhancing operational resilience and supporting organizational objectives in an era of increasing financial pressures and complex supply chains. The study examines data analytics approaches, such as spend analysis, predictive cost modeling, and demand forecasting, which enable organizations to uncover cost-saving opportunities and streamline procurement processes. Additionally, it highlights how data-driven vendor management, through continuous evaluation, risk assessment, and performance tracking, contributes to sustainable supply chain efficiency. Key recommendations include establishing data governance frameworks, investing in advanced analytics tools, enhancing data literacy among procurement teams, and fostering transparent supplier relationships. By integrating analytics into procurement strategies, organizations can achieve long-term cost efficiency, build stronger supplier partnerships, and support sustainable growth.
From Menarche to Menopause: Exploring reproductive health awareness among pakistani women
Authors: Asad Riaz  , Bissma Laraib  , Ayesha Aftab Mirza  , Aiman Waseem  , Abdul Muhymin Alam Khattak  , Aabdar Hidayat  , Attal Khan  , Hasham Shahid  , Momna Basheer  , Muneeeb Iqbal  , Shah Abdul Aziz  , Anam Riaz
Published: December 2024

Introduction: Women's reproductive health knowledge is crucial for their well-being, particularly in LMICs like Pakistan, where cultural barriers often prevent open discussions. This study explores the reproductive health awareness among Pakistani women, focusing on menstruation, contraception, STD prevention, pregnancy, and menopause.
Methods: Data were collected from 125 Pakistani women aged 15–49, covering demographics, menstrual knowledge, STD awareness, contraception, AIDS awareness, menopause, and general reproductive health knowledge.
Results: Participants, aged 17–46, were mostly married, urban, educated, and from middle-income backgrounds. Only 45.6% knew about menarche before it occurred, and 54% received counseling at its onset. Medical help was preferred for fertility issues, but traditional methods were used for pregnancy termination. While 65.6% were aware of STDs, awareness was higher in urban areas. Only 37% were aware of menopause-related health risks. Contraceptive use was low, with educated women showing better timing knowledge. About 59% knew about AIDS, with media as a primary source. The term “reproductive health” was unfamiliar to 78% of participants. Cultural norms, shyness, and limited sources were reported as major barriers.
Discussion: Significant gaps in reproductive health knowledge highlight urban-rural disparities and the influence of cultural barriers. Women sought medical advice for fertility but relied on traditional practices for terminations. Effective educational initiatives could address misconceptions, especially around STDs, contraception, and menopause.
Conclusion: Reproductive health education in Pakistan is essential for empowering women. Enhanced programs, culturally sensitive approaches, and accessible platforms are needed to address knowledge gaps, enabling informed decisions and better health outcomes.
Importance, diversity and economic value of trees associated with cocoa trees in different agroforestry systems
Authors: Mada DOUMBIA, Ollo SIB  , Yao Anicet Gervais KOUAME  , Senan SORO  , N’Guessan Lucie YEBOUE  , Karidia TRAORE
Published: December 2024

The expansion of cocoa cultivation in Côte d'Ivoire, although crucial to the national economy, has been at the expense of forest cover, leading to massive deforestation, loss of biodiversity and degradation of essential ecosystem services. Cocoa-based agroforestry systems (SAFc), incorporating shade trees, are increasingly being promoted as a sustainable solution for reconciling agricultural productivity and environmental conservation. This study aimed to (1) characterise the floristic diversity of shade trees associated with cocoa trees in different SAFc in the Nawa region; (2) assess the structural characteristics of these trees; (3) estimate biomass and carbon sequestration of SAFc; and (4) compare the economic value of trees associated with SAFc. Sixteen (16) cocoa plantations representing four types of SAFc (full sun systems, shaded systems and two intermediate systems) were selected and floristic surveys were carried out. A total of 83 tree species in 62 genera and 32 botanical families were recorded, with higher species richness in shaded systems (52 species) and intermediate 2 (40 species). Structural analysis revealed a predominance of young trees (diameter class [10-20] cm), suggesting active regeneration. Overall, the results indicate that intermediate SAFc systems offer an optimal balance between cocoa productivity, biodiversity conservation and the provision of ecosystem services, particularly in terms of biomass accumulation and carbon sequestration. Promoting intermediate SAFc could therefore strengthen the sustainability of cocoa production in Côte d'Ivoire.
Effectiveness of low-level laser therapy on oral wound healing: A scoping review
Authors: Adiastuti Endah Parmadiati  , Yasmin Kamila Putri  , Indah Alya Zahra  , Dhea Rima Rohita Zulfa
Published: December 2024

Low-level laser therapy (LLLT) has gained attention as a non-invasive approach for enhancing wound healing across various clinical applications. This review evaluates the effectiveness of LLLT on healing rates, pain reduction, and functional improvement across different conditions, including oral ulcers, aphthous stomatitis, diabetic ulcers, knee osteoarthritis (KOA), and bone healing with platelet-rich plasma (PRP). LLLT demonstrated high effectiveness in soft-tissue-related conditions, achieving notable healing rates (88% in aphthous stomatitis) and substantial pain relief (around 80% in oral conditions). However, its effectiveness was lower in bone-related conditions, indicating the potential need for combination therapies. LLLT also showed moderate improvements in functional outcomes, particularly in joint-related conditions like KOA. The photobiomodulatory effects of LLLT stimulate cellular regeneration, reduce inflammation, and promote pain relief, making it especially beneficial for soft-tissue ailments. These findings suggest that LLLT’s effectiveness varies by tissue type and treatment intensity, underscoring the importance of tailoring protocols for different conditions. Future research should focus on standardizing LLLT parameters for consistent outcomes across diverse clinical applications. This study supports the integration of LLLT as an adjunctive therapy, particularly in conditions where rapid tissue repair and pain management are crucial.
Comparative analysis of farming income of “Kalibening” avocado nursery in Jambu sub-district, Semarang district
Authors: Rohmad  , Wulan Sumekar  , Edy Prasetyo
Published: December 2024

Indonesia is an agricultural country where some of its people depend on the upstream and downstream aspects of the agricultural sector. There are some farmers who cultivate by growing crops to gardening and some who cultivate nursery businesses, be it fruit nurseries or seasonal or annual horticultural crops such as avocados. Ownership of farm land between own land and rented land causes differences in avocado nursery farm income. The objectives of the study were: 1. Analyzing the revenue and cost ratio (R/C ratio) and break-even point (BEP) in the kalibening avocado nursery business using self-owned media and leased land. 2. Analyze the comparative income of Kalibening avocado nursery farming businesses Hectares use leased land media and owned land media on members of the Kebondalem Village Farmers Group, Jambu District, Semarang Regency. 3. Comparative analysis using independent sample t test. Based on the analysis of farm income, the kalibening avocado nursery with self-owned land planting method is IDR. 1,424,634,204, - / year with an average land area of 0.05 Hectares, while on rental land planting media is IDR. 2,520,341,150, - / year on an average land area 0.01 Hectares. The results of the research on self-owned land R/C ratio of 1.80, on rented land R/C ratio of 1.58. So it can be concluded Hectares both businesses are feasible to run. BEP results on self-owned land amounted to IDR. 6,093, while on rented land BEP amounted to IDR. 10,658. The results of the Income Difference Test are known to be 0.000 <0.05 so it can be concluded Hectares there is a significant difference in income between self-owned land and rented land.
Navigating complex mergers: A blueprint for strategic integration in emerging markets
Authors: Richard Okon  , Stephane Jean Christophe Zouo  , Adedamola Sobowale
Published: December 2024

This study explores strategic integration in mergers and acquisitions (M&A), focusing on emerging markets. As M&A activity in these regions grows, companies face unique challenges due to diverse regulatory environments, cultural dynamics, and operational complexities. This research aims to provide a comprehensive framework to navigate these complexities, identifying core integration components, external influencing factors, technological advancements, and associated challenges. Methodologically, the study synthesizes existing literature on M&A integration, analyzing key strategic approaches across cultural alignment, risk management, and operational harmonization. Key findings indicate that successful strategic integration requires technological and human-centered approaches, including tools like ERP systems, data analytics, and cloud computing, which streamline operations, and emphasize cultural alignment, leadership synergy, and proactive risk management. Additionally, the study underscores the impact of regulatory and economic factors on integration strategies, highlighting the need for adaptable frameworks tailored to the complexities of emerging markets. The study concludes that structured integration strategies and flexible, technology-driven frameworks foster long-term M&A success and competitive advantage. Recommendations include adopting sustainable integration models, enhanced cross-functional collaboration, and robust regulatory compliance strategies. Future research opportunities are outlined, particularly regarding open innovation and sustainable practices in emerging market M&A.
The art of due diligence: Lessons learned from multimillion-dollar investment deals
Authors: Richard Okon  , Stephane Jean Christophe Zouo  , Adedamola Sobowale
Published: December 2024

This study explores the integral role of due diligence in multimillion-dollar investment transactions, specifically focusing on mergers and acquisitions. The research aims to elucidate how due diligence practices have evolved from traditional, checklist-based assessments to complex, multi-dimensional analyses encompassing financial, operational, and strategic considerations. This evolution reflects the increasing need for comprehensive risk management tools that enhance decision-making and safeguard investments against unforeseen challenges. The study employs a qualitative approach, examining various case studies and literature to reveal the impact of due diligence on investment outcomes and the critical elements that contribute to its effectiveness. Key findings indicate that effective due diligence practices not only mitigate risks but also facilitate post-merger integration and create value by identifying potential synergies. The incorporation of environmental, social, and governance (ESG) criteria, along with advanced technologies like artificial intelligence and data analytics, has further strengthened due diligence frameworks, enabling more precise and transparent evaluations. However, challenges remain, particularly in cross-border transactions where regulatory and cultural differences can complicate the process. The study concludes that due diligence must continuously adapt to address the demands of a dynamic investment environment. Recommendations include adopting proactive, technology-driven approaches to due diligence, integrating ESG assessments to meet stakeholder expectations, and enhancing cross-functional collaboration. This approach will enable investors to make informed, sustainable decisions aligned with long-term value creation.
Geographical variations in HLA-B27 prevalence and its relationship with rheumatological disorders: A systematic review and meta-analysis
Authors: Kalash Dwivedi  , Gulizebo Bakhtiyor kizi Saidrasulova  , Vinayak Koli  , Muthulingam Sharavanan Gayathri Srikanth
Published: December 2024

This systematic review and meta-analysis tries to examines the geographic and methodological variation in HLA-B27 prevalence and its association with rheumatological disorders such as rheumatoid arthritis or Ankylosing Spondylitis in different countries using data from seven studies in screening between 1977 and 2022, including cross-sectional, This study, as well as a prospective cohort study, reveals considerable heterogeneity in HLA-B27 prevalence Japan (78 %) found a high prevalence, which was significantly linked with ankylosing spondylitis. In contrast, lower prevalence was found in Colombia (4.5%) and France (9.6% of patients with RA), suggesting a clinically variable importance (based on our selected article). These findings highlight the influence of geographic and ethnic factors on the role of HLA-B27 in rheumatoid arthritis and highlight the need for regionally specific screening and management strategies. Future research should investigate the interactions between HLA-B27 and other genetic and environmental factors to refine diagnostic and therapeutic strategies. It is important to note that some studies were published earlier but became online available recently in years and decade.
Innovations in mRNA-based cancer immunotherapy: Challenges and future directions
Authors: Matthew Essuah  , Buniechukwuenu Emmanuel Mbamalu  , Ridwan Ayodele Akanmu  , Sunday Kaura  , Barakat Tope Kareem  , David Oluwafemi Ibikunle  , Hajara Hashim
Published: December 2024

Messenger RNA (mRNA) vaccines have quickly become a potent tool in cancer immunotherapy, with the potential to personalise cancer treatment and get around many of the drawbacks of conventional therapies. With an emphasis on their processes, technological developments, and clinical applications, this study examines the scientific breakthroughs and difficulties surrounding mRNA cancer vaccines. We begin by investigating the ways in which mRNA vaccines work to stimulate the immune system, encode antigens specific to tumours, and elicit a potent anti-tumor response. We also look at the variety of mRNA vaccines which are currently being deployed and emphasize their successes in clinical studies, especially when combined with immune checkpoint inhibitors. The effectiveness and safety of these vaccines have been significantly increased by technological developments, such as enhancements in mRNA stability, design, and delivery systems (such as lipid nanoparticles and polyplexes). Emerging technologies like circular RNA and self-amplifying present promising opportunities for enduring and more potent therapies. But there are still limitations with mRNA vaccines, such as stability, immunogenicity, degradation, and effective in vivo delivery. Concerns about possible adverse effects and safety in long-term applications are also covered in this review. Despite these obstacles, novel approaches are being developed to boost antigen expression, optimize delivery systems, and improve mRNA stability, establishing mRNA vaccines as a crucial component of tailored cancer immunotherapy. These developments provide the foundation for upcoming advances in mRNA vaccine technology and represent a major breakthrough in the fight against cancer.
Analisis Keamanan Kapal Perikanan Tangkap Pukat Cincin yang Berpangkalan di PPI Desa Waai Berdasarkan Parameter Desain
Authors: Metekohy Obed
Published: December 2024

The fishing operations of ring seine fishing boats in Waai Village, in the waters of Banda, Seram, and Haruku Strait, present promising opportunities with abundant fish stocks. However, the extreme weather conditions in the fishing grounds pose significant challenges to the fishing operations, particularly due to inadequate fishing facilities. The design and construction of the boats play a crucial role in influencing operational characteristics, especially during the processes of setting, pursing, hauling, and while the boats are en route to and from the fishing grounds. This study aims to analyze the design of ring seine boats based at the Fish Landing Base (PPI) in Waai Village, focusing on the main dimensional ratio, hull form coefficient, and static stability of the boats. The primary objective is to improve the efficiency of fishing operations and ensure the safety of fishermen at sea. The method used in this research is a survey method, with a sample of eight ring seine boats. The results of the study show design characteristics with a main dimension ratio of 37.50%, hull form coefficient of 65.62%, and a metacentric height stability value of 25%, which meet the standard design requirements for static stability. However, the rolling period value of 62.50% does not meet the standard, indicating that improvements in boat design are necessary to enhance stability.
Implementasi Peningkatan Produktivitas Perusahaan dengan Metode American Productivity Center pada UD. XY
Authors: Pattiapon Marcy Lolita , Maitimu Nil Edwin
Published: December 2024

The company's main goal is to achieve maximum profits. To achieve this goal, the company carries out its business operations. Operational processes are carried out by paying attention to productivity levels. Productivity plays an important role for companies in facing intense business competition, so every company is required to improve its performance in order to compete with other competitors. UD. XY is an industry that focuses on the furniture sector and produces household furniture. The problem faced by the company was UD's inability. To evaluate the level of productivity that has been achieved in previous years. This research aims to identify productivity UD. XY and analyze changes in the input used by the company, so that it can determine the input aspects that require improvement to increase productivity. The approach used to analyze productivity levels is through the American Productivity Center (APC) method, which allows comparisons between the value of input issued and the output obtained. The research results show a decline in productivity, where the productivity index was recorded to have fallen by -1.7% in 2022, -3.2% in 2023, and -2.1% in 2023. This decline was caused by the company's internal problems, namely inefficiency in the use of resources which ends in increased production costs. In 2023, even though the output value reached IDR 3,219,000,000, productivity still decreased by -2.0%, so the company experienced a loss in resource utilization which reached IDR 64,380,000 in 2023.
ANALISIS EFISIENSI BIAYA PERSEDIAAN BAHAN BAKU SPRINGBED MENGGUNAKAN METODE EOQ PADA PT. CAHAYA BINTANG MANISE
Authors: Chaniago Yusril , Maitimu Nil Edwin , Pattiapon Marcy L.
Published: December 2024

Cahaya Bintang Manise telah melakukan perencanaan persediaan bahan baku. Perencanaan ini dilakukan oleh bagian Production Planning Inventory Control (PPIC). Akan tetapi, perencanaan kebutuhan bahan baku yang dilakukan belum optimal, karena bahan baku yang diterima perusahaan tidak sesuai dengan waktu pemesanan bahan baku dan standard yang diharapkan, sehingga produksi menjadi terganggu dan menumpuknya bahan baku. Tujuan dalam penelitian ini adalah untuk mengetahui total biaya persediaan menggunakan metode Economic Order Quality (EOQ). Dari hasil analisis dapat disimpulkan bahwa perbandingan total biaya persediaan terhadap delapan bahan baku didapatkan hasil delapan jenis bahan baku yang mendapatkan hasil yang efisien dengan menggunakan metode Economic Order Quantity  (EOQ) yaitu per, kawat, busa roll, kain woven, benang quilting, cotton cheet 165, pipa foam, dan benang extra jeans.
ANALISIS PENGARUH TEMPAT PENYALURAN DISTRIBUSI TERHADAP MUTU BBM PERTAMAX RON 92 MENGGUNAKAN DESAIN EKSPERIMEN
Authors: Yuliana Yuliana , Tutuhatunewa Alfredo , Tupan Johan Marcus
Published: December 2024

Pertamax RON 92 merupakan jenis bahan bakar dengan fraksi ringan yang dikeluarkan oleh PT. Pertamina. Dalam penelitian ini dilakukan analisis terhadap mutu pertamax berdasarkan tempat penyalurah distribusi dengan menggunakan desain eksperimen pada SPBU Kota Ambon. Metode yang digunakan adalah observasi lapangan dan pengumpulan data serta pengujian bahan bakar Pertamax RON 92 yang dilakukan sebanyak tiga kali pengulangan produk pertamax yang diletakkan pada kondisi 0ºC. Parameter uji yang diukur adalah Density, Reid Vapor Pressure (RVP), Destilasi dan Sulfur. Dengan Hasil analisis pengujian bahan bakar didapat bahwa tidak terdapat pengaruh yang signifikan dari lokasi penyaluran BBM Pertamax Ron 92, dengan nilai kualitasnya. Hasil pengujian statistik menunjukkan bahwa nilai density, nilai Reid Vapor Pressure (RVP), nilai destilasi, dan nilai sulfur tidak berbeda secara signifikan antara ketiga SPBU yang diuji.
REDESIGN ALAT TANGKAP IKAN (BUBU) DENGAN MEMPERTIMBANGKAN VOICE OF CUSTOMER MENGGUNAKAN METODE QUALITY FUNCTION DEPLOYMENT (QFD)
Authors: Latumeten Erza Ferlianty , Pattiapon Marcy L. , Tutuhatunewa Alfredo
Published: December 2024

Masyarakat Negeri Larike hidup di wilayah pesisir dan mayoritas berprofesi sebagai nelayan. Potensi laut yang begitu besar menjadi kekuatan untuk meningkatkan kesejahteraan masyarakat. Mayoritas penangkapan ikan bagi nelayan di Negeri Larike masih tradisional. Saat ini nelayan desa Larike menggunakan bubu yang berukuran 2 meter untuk penangkapan ikan dan biota laut lainnya. Tujuan penelitian ini adalah untuk menghasilkan desain bubu ikan yang dapat menunjang kenyamanan bagi pengguna dan menambah ketahanan agar mendapatkan hasil yang lebih baik dibandingkan dengan bubu sebelumnya berdasarkan keinginan konsumen. Hasil penelitian ini yaitu mulai dari pembentukan Voice of Customer hasil dari pernyataan tersebut diinterpretasikan menjadi kebutuhan pengguna. Penentuan Costumer Needs kebutuhan pengguna ini didapatkan dari hasil voice of costumer yang telah dilakukan sebelumnya. Pembentukan Planning Matrix untuk nilai ItC didapatkan tiga atribut yang memiliki bobot lebih tinggi yaitu kemudahan dalam penggunaan, variasi volume yang dapat ditampung, dan tahan lama dengan nilai sebesar 4,5%. Untuk nilai CuSP variasi volume yang dapat ditampung sebesar 3,50%. Untuk nilai CoSP kemudahan dalam penggunaan sebesar 3,50%. Dari hasil penjambaran Peta Morfologi, maka redesain Alat Tangkap Ikan Bubu yang baik, menarik, dan tahan lama sehingga dapat memenuhi kepuasan dan keinginan nelayan untuk penangkapan ikan sesuai dengan fungsi dari alat tangkap tersebut.
PENALARAN VISUAL SISWA DALAM MEMECAHKAN MASALAH LUAS BANGUN DATAR
Authors: Ashari Nur Wahidin
Published: December 2024

Penelitan ini bertujuan untuk mendeskripsikan penalaran visual siswa dalam memecahkan masalah luas bangun datar. Subjek penelitian adalah 3 orang siswa kelas VII C Madrasah Tsanawiyah Batusitanduk. Tiga subjek dalam penelitian yang dipilih berdasarkan pemberian tes penalaran visual disertai think aloud dan wawancara. Pendekatan kualitatif digunakan dalam penelitian ini. Instrumen utama dalam penelitian ini adalah peneliti sendiri. Adapun instrument pendukungnya yaitu; tes penalaran visual dan pedoman wawancara. Analisis data yang digunakan yaitu dengan mengumpulkan data, direduksi, kemudian penyajian, dan penarikan kesimpulan. Hasil Penelitian menunjukkan bahwa (1) kemampuan penalaran siswa pada indikator investigatting, ditunjukkan dengan siswa dapat langsung mengerjakan soal yang diberikan karena dapat dengan mudah menggali data dari informasi visual yang terdapat pada soal ; (2) Kemampuan penalaran visual siswa pada indikator interpreting, ditunjukkan dengan siswa dapat menemukan hubungan antar data berdasarkan informasi visual yang terdapat pada soal serta menjelaskan ide-ide yang dituliskannya ; (3) Kemampuan penalaran visual siswa pada indikator appliying, siswa dapat  menganalisa dengan baik informasi visual yang diberikan dengan melakukan perhitungan terhadap nilai-nilai yang diperoleh.
“O PESSOAL DO CEARÁ”: UMA GENEALOGIA DA CRIAÇÃO DO PROGRAMA DE PÓS-GRADUAÇÃO EM FILOSOFIA DA UFC
Authors: Sampaio Evaldo Silva Pereira
Published: December 2024

Trata-se aqui da formação do Programa de Pós-Graduação em Filosofia da UFC. A questão a ser investigada diz respeito à quais condições e perspectivas conduziram à criação do PPGFILO-UFC e como tal aparecimento nos permite compreender acerca da origem e do desenvolvimento do ensino universitário de Filosofia no Brasil. A hipótese que pretendo justificar é de que o ensino acadêmico de Filosofia no Ceará seguiu um caminho próprio em relação a outros centros de pesquisa do país, e, no caso do PPGFILO-UFC, deu-se inicialmente uma orientação filosófica germânica e metodologicamente sistemática. Se tais hipóteses estiverem corretas, uma genealogia do PPGFILO-UFC tanto permite ressignificar uma outra avaliação da Filosofia no Ceará quanto sua inserção nacional, bem como reforça o abandono de certas interpretações que estabelecem algum núcleo institucional para a nossa Filosofia contemporânea.
CONHECIMENTO RELACIONAL E O CONCEITO FUNCIONAL DE NÚMERO: ASPECTOS ESTRUTURANTES DO PROGRAMA FILOSÓFICO DE ERNST CASSIRER
Authors: Azevedo Júnior Ivânio Lopes de
Published: December 2024

O objetivo do presente artigo é o de explicitar e analisar dois aspectos estruturantes da filosofia de Ernst Cassirer, a saber: a) a defesa do caráter relacional do conhecimento e b) a natureza funcional do conceito de número. Ambos consistem em traços que marcaram o programa filosófico do autor, bem como várias de suas agendas de pesquisa. O debate no qual essa discussão é desenvolvida diz respeito ao problema em torno da formação dos conceitos científicos e à resistência à perspectiva metafísica que, por sua vez, assumiu pressupostos pré-críticos quando da interpretação dos conceitos em termos substanciais. A noção de conhecimento relacional – que encontra, na matemática, o exemplo de como os conceitos se formam independentemente da abstração metafísica – consiste em um aspecto fundamental no pensamento cassireriano. O simbolismo de Cassirer, sem o qual não teria sido possível a sua crítica da cultura, pressupõe o devido desenvolvimento da tese de que conhecer é construir relações lógico-epistêmicas.
NATUREZA E NEGAÇÃO DA VONTADE LIVRE EM FEUERBACH
Authors: Chagas Eduardo Ferreira
Published: December 2024

O presente artigo pretende destacar a tese de que a natureza, conforme Feuerbach, é um existente autônomo e independente e possui primazia ante o espírito. Sob essa condição, é possível conceber a natureza como a garantia da exterioridade mesma, como que um existente fora de nós, que nada sabe de si e é em si e por si mesmo; por conseguinte, ela não deve ser vista como aquilo que ela não é, isto é, nem como divina, nem como humana. A natureza sempre existiu, quer dizer, ela existe por si e tem seu sentido apenas em si mesma; ela é ela mesma, ou seja, nenhuma essência mística, pois, por trás dela, não se esconde nenhum absoluto, nada humano, nada divino, transcendental ou ideal. Trata-se aqui também de uma exposição da ética materialista, a-posteriorística, de Ludwig Feuerbach a partir de sua crítica a toda ética apriorística, transcendental, ilimitada, indiferente, imediata, pura, vazia de conteúdo, abstraída das determinações, da situação concreta, baseada numa vontade incondicionada, indeterminada, numa pretensa liberdade humana independente tanto dos limites e das leis da natureza externa, quanto da natureza interna, da determinação corporal e das necessidades naturais humanas. Com isso, não há, todavia, em Feuerbach um determinismo ou uma negação da vontade, mas a defesa de que a liberdade humana não é absoluta e incondicionalmente livre, mas condicionada pelo tempo, pelo momento histórico, pela idade, por meios materiais e sensíveis, pela situação ambiental, pelas condições e circunstâncias da natureza, como alimento, vestimentas, luz, ar, água, espaço e tempo, pois ter vontade é sempre ter vontade de algo, já que ela é sempre vontade mediada por um objeto, e é só através das condições e mediações que se alcança a liberdade, e, assim, a vontade se torna concreta.
SER, CONSCIÊNCIA, LINGUAGEM E DECOLONIAL: HORIZONTES DA FILOSOFIA
Authors: Aguiar Odílio Alves , Macedo Rodrygo Rocha
Published: December 2024

O artigo almeja articular os horizontes do ser (Filosofia Antiga e Medieval), da consciência (Filosofia Moderna) e da linguagem (Filosofia Contemporânea) presentes na história da Filosofia, ressaltando a dimensão cosmológica, no primeiro momento, gnosiológica, no segundo, e linguística, no último, como uma forma de explicitar os paradigmas pressupostos nos discursos filosóficos. Além desses horizontes, iremos avançar, também, em direção ao horizonte decolonial ou pós-colonial e, assim, realizar a atualização dos paradigmas atualmente vigentes, especialmente na filosofia latino-americana.
SENSOPERCEPÇÃO, AMOR E SABER: REVISITANDO O ASCETISMO PLATÔNICO
Authors: Araújo Hugo Filgueiras de , Freitas Jéssyca Aragão
Published: December 2024

A partir de uma leitura integrada dos diálogos Fédon e Banquete, pretendemos revisar a interpretação tradicional de Platão como um filósofo que despreza o corpo e os sentidos, demonstrando que a filosofia platônica entrelaça amor, sensopercepção e saber. No Fédon, destacamos a importância das sensopercepções para a anamnese. No Banquete, apresentamos Éros como um impulso inerente à constituição humana, cujo desejo pelas coisas belas é capaz de elevar os indivíduos à contemplação das formas inteligíveis. Através da abordagem desses diálogos, torna-se claro que Platão não defende um ascetismo radical, mas reconhece o corpo e o desejo como elementos fundamentais para a atividade filosófica, estabelecendo que o amor e a sensibilidade são condições de possibilidade para o acesso ao verdadeiro saber.