bluuebunny/crossref_metadata_2025 huggingface dataset:
« Papa Eugenius transferri fecit »: Le De fide orthodoxa et sa reception entre XIIe et XIIIe siècle à travers le manuscrit Pise, Biblioteca Cathariniana, 2
Authors: Saccenti Riccardo
Published: April 2023

L’article propose une étude du manuscrit Pisa, Bibliotheca Cathariniana, MS 2, un codex du milieu du XIIIe siècle contenant le De fide orthodoxa de Jean Damascène dans la traduction latine de Burgondio de Pise. L’étude analyse les caractéristiques du texte dans ce manuscrit, en notant la présence des traces de la méthode de traduction utilisée par Burgundio au milieu du XIIe siècle. Elle analyse également les gloses dans les marges, qui suggèrent l’utilisation du manuscrit à des fins pédagogiques dans un contexte profondément lié à la réception des influences théologiques parisiennes. Elle montre en particulier la présence de références croisées à des passages des Sentences de Pierre Lombard et à deux questions disputées de Guerric de Saint-Quentin. L’étude vise à présenter ce manuscrit comme un témoin de l'histoire ‘plurielle’ du discours doctrinal dans l'Europe des XIIe et XIIIe siècles.
Endlich! Zum Erscheinen der kritischen Edition der lateinischen Fassung des Wegweisers für die Verirrten von Maimonides
Authors: Imbach Ruedi
Published: April 2023

Review article of:

Moses Maimonides, Dux neutrorum vel dubiorum, pt. I, ed. Diana Di Segni, Peeters, Leuven 2019 (Recherches de Théologie et Philosophie médiévales, Bibliotheca, 17, 1).
« Noi siamo fatti della stessa sostanza dei sogni, e nello spazio e nel tempo d’un sogno è raccolta la nostra breve vita »: Una riedizione del Somniorum Synesiorum Libri IIII e una nuova edizione del De vita propria di Girolamo Cardano
Authors: Tamborini Massimo
Published: April 2023

Review article of:

Jérôme Cardan, Traité des songes / De somniis, Édition, traduction, introduction et notes par Jean-Yves Boriaud, Les Belles Lettres, Paris 2021 (Les Classiques de l’Humanisme), XXXV + 953 pp.;

Jérome Cardan, Le livre de ma vie / De vita propria, Introduction, édition et traduction par Jean-Yves Boriaud, Les Belles Lettres, Paris 2020 (Les Classiques de l’Humanisme), XXVI + 406 pp.
George Amiroutzes, The Philosopher, or On Faith, edited and translated by John Monfasani, Harvard University Press, Cambridge, MA 2021 (Graphai, 1), 256 PP., ISBN: 9780884024859
Authors: O'Meara Dominique
Published: April 2023

Review of:

George Amiroutzes, The Philosopher, or On Faith, edited and translated by John Monfasani, Harvard University Press, Cambridge, MA 2021 (Graphai, 1), 256 PP., ISBN: 9780884024859.
Karla Mallette, Lives of the Great Languages: Arabic and Latin in the Medieval Mediterranean, The University of Chicago, Chicago – London 2021, 240 PP., ISBN: 9780226795904
Authors: Burnett Charles
Published: April 2023

Review of:

Karla Mallette, Lives of the Great Languages: Arabic and Latin in the Medieval Mediterranean, The University of Chicago, Chicago – London 2021, 240 PP., ISBN: 9780226795904.
In memoriam Shlomo Sela (9.I.1948–26.VII.2022)
Authors: Harvey Steven , Garshtein Niran
Published: April 2023

In memoriam Shlomo Sela (9.I.1948–26.VII.2022).
In memoriam John W. O’Malley, S.J.	(11.VI.1927–11.IX.2022)
Authors: Russell Camilla
Published: April 2023

In memoriam John W. O’Malley, S.J. (11.VI.1927–11.IX.2022).
The Unity of the Soul: Metaphysics, Psychology and Problems in the First Jesuit Parisian Lecture On the Soul (1564)
Authors: Tropia Anna
Published: April 2023

The paper reconstructs the conception of the soul by the Spanish Jesuit Juan Maldonado, one of the first Jesuits who lectured on the Aristotelian De anima, through the analysis of the synthesis of the lectures he gave in Paris. Maldonado maintains the definition of the soul as form of the body but also suggests that there are more forms in the human compound. The paper aims to solve this tension through the comparison with the later De anima by Francisco Suárez.
Two Sixteenth-Century Coimbra Commentaries on 'De anima': Pedro da Fonseca (attr.) and Cristóvão Gil. 'On the Soul' and 'On the Immortality of the Soul'
Authors: Oliveira e Silva Paula
Published: April 2023

This paper analyses the questions on the science of the soul and on the immortality of the soul in two commentaries on Aristotle’s De anima that subsist in the manuscripts of the teaching of philosophy in Coimbra in the sixteenth-century. The paper shows that the positions of the two commentators – Petrus Fonsecae (attr.) and Christophorus Gilli – are in total opposition, concerning either the commentary tradition on Aristotle’s De anima or the theories on the soul they assume. Focused on unpublished and less studied sources this research brings to light some innovative aspects of the teaching of philosophy in Coimbra. We thus suggest that the manuscript sources of the period be reassessed and studied in comparison to the published works.
Prevalence and Antimicrobial Sensitivity Pattern of MRSA Isolated from Infection Wound, Catheters Swabs and Sewage Water Samples
Authors: Sharma Rohini , Ahuja Dharmendra
Published: April 2023

Nosocomial infection is a major problem in the world today. Methicillin- resistant Staphylococcus aureus (MRSA) strains, usually resistant to several antibiotics and also intrinsic resistance to ß- lactam antibiotics, shows a particular ability to spread in hospitals and now present in most of the countries. The present study was carried out to investigate the prevalence of MRSA and their rate of resistance to different anti staphylococcal antibiotics. A total of 100 health care associated (HA) sources such as wound, catheters swabs and sewage water samples were screened for MRSA and their antibiotic resistance pattern was performed. Out of 41 isolated strain of S.aureus, 34% were found to be methicillin resistant. There was high prevalence of MRSA in wound (44%), catheter samples (28%) and (22%) in sewage water sample. Almost all MRSA strains were resistant to penicillin followed by cloxacillin and cephalexin, co-trimoxazole. About 60-70% MRSA strains were resistant to erythromycin, ceftazidime, lincomycin, cephalexin, erythromycin and tetracycline. The determination of prevalence and antibiotic sensitivity pattern of MRSA will help the treating clinicians for first line treatment in referral hospitals.
Nephroprotective Activity of Some Indigenous Medicinal Plants in Cisplatin Induced Nephrotoxicity
Authors: Kumar Servesh , Soni Vishal
Published: April 2023

Aim: The aim of the present investigation is to study the nephroprotective activity of two indigenous medicinal plants. Material and methods: Dried leaves of Alstonia scholaris and Centella asiatica were procured from the medicinal garden and campus of Pharmacy College in the month of September, Bhopal, Madhya Pradesh, India. Around 500 gm dried leaves of Alstonia scholaris and Centella asiatica were coarsely powdered weighed and filled in Soxhlet apparatus for extraction. Wistar albino rats of either sex between 2 and 3 months of age weighing 150-200 gm were used which were procured from the central animal house. The acute oral toxicity studies were carried out according to the guidelines set by the Organization for Economic Co-operation and Development (OECD), revised draft guideline 423. Cisplatin (5mg/kg, i.p) was administered to the rats. The study was conducted for 15 days and the rats were divided into 12 groups (n=6). Rsults: Among all the extracts of Centella asiatica, methanolic extract showed a significant effect (P>0.01) as compared to other extracts. This shows that at these doses of 200 and 400 mg/kg the extract have preventive and protective potential against Cisplatin renal toxicity, suggesting it renal preventive role. Among all the extracts of Alstonia scholaris, dichloromethane extract showed a most highly significant effect (P>0.001) as compared to other extracts. Methanolic extract also showed significant effect (P>0.01) as compared to other extract. Petroleum ether showed almost negligible effect. Conclusion: The results obtained in this study have shown that extracts displayed significant nephroprotective activity in both acute and chronic conditions. Besides from the obvious therapeutic importance, these components would be useful in understanding the mechanism of diseases with higher levels of cellular and molecular level.
Stereochemistry of Dihydropyrimidinones Derivatives Synthesized by Brick Dust Catalytic Reaction
Authors: Chauhan Divya , Nayak Surendra Kumar , Sahu Sanjeev Kumar
Published: April 2023

A number of catalytic synthetic reactions have been reported which play the important role in stereochemistry of compounds. The key to the success of this protocol was the generation of stereogenic centers in 1, 4-Dihydropyrimidinones (DHPMs) and the influence of catalysts on their configuration. Waste brick dust was found to be an effective catalyst, generating chiral DHPMs derivatives using aryl aldehyde, urea, and ethyl acetoacetate. This work mainly focuses on the stereochemistry of brick-dust catalyzed DHPMs derivatives. Discovery of brick dust catalyst associated with several benefits such as rapid clean reaction, simple, and ease work-up.
Antibiofilm Activity of the Methanolic Extract of Nutmeg Oil against Bacillus subtilis
Authors: M Bhavana M , K Vidya Prabhakar
Published: April 2023

Biofilm is formed by one or different types of microbes that can grow on different surfaces. Bacteria, fungi, and many protists can form biofilms. Biofilm formation requires cell to cell signaling mechanism which is defined as quorum sensing. In this work, we have studied about the antibiofilm activity of methanolic extract of nutmeg against Gram-positive Bacillus subtilis bacteria. Our test extract inhibited biofilm production as well as eradication of pre-formed biofilm in B. subtilis. Extracellular polymeric substance (EPS) is the biopolymer of microbial origin in which biofilm producing microbes are embedded. When test extract was treated with organisms producing biofilms it can also reduce the production of EPS of biofilm. All the quantitative analysis of this work concludes that methanolic extract of Myristica fragrans seed extract inhibited biofilm formation by 47%, eradicated the pre-formed biofilm by 28.5%, and inhibited EPS formation by 60%. All these quantitative tests were confirmed by microscopic analysis. All Our study concludes that M. fragrans seed extract can inhibit biofilm formation and can destruct preformed biofilm in Gram-positive bacteria.
How widespread is Thyroid Disorders among Patients undergoing Coronary Artery Bypass Grafting? A Study from Tertiary Care Hospital
Authors: Kahol Richa , Kathait Atul , Mishra Sunil Kumar , Bhan Anil , Trehan Naresh
Published: April 2023

Coronary artery bypass grafting (CABG) is the most commonly performed cardiac procedure and thyroid disorders (hypothyroidism and hyperthyroidism) are the most widespread endocrine diseases. Till date, there is no Indian study pertaining to prevalence of thyroid disorders among subjects undergoing CABG. The aim of this study was to determine the prevalence of thyroid disorders among subjects undergoing CABG in a tertiary care hospital. This is a prospective observational hospital-based study having 560 subjects who underwent CABG. Pre-operative thyroid tests were conducted of all the subjects. On the basis of this test, subjects were divided into groups, “Euthyroid” (normal thyroid status) and Thyroid subjects, that is, Subclinical Hypothyroidism (SCHypo), Overt Hypothyroidism (OVHypo), Subclinical Hyperthyroidism (SCHyper), and Overt Hyperthyroidism (OVHyper), based on thyroid function test. The proportion of the disorders was calculated. The study population included 560 subjects (Males: 457 females: 103). The overall prevalence of thyroid function abnormalities was 41.07%. The SCHypo was the most pervasive thyroid disorder (33.75%), followed by SCHyper (4.28%), OVHypo (2.32%), and OVHyper (0.7%). Highest number of thyroid subject (57.8%) was in 40–59 age group and lowest (0.86%) in 18–39. Thyroid was more prevalent among females (45/103) than in males (185/457). Among subjects undergoing CABG, SCHypo was most common followed by SCHyper, OVHypo, and OVHyper. Among the subjects undergoing CABG, maximum thyroid cases are in the age group of 60–79 with female preponderance.
Comparison of Use of Concentrated Saliva with Serial Dilution Method in Determination of Candida Colonies in Oral Samples
Authors: Bhat Nitish , Anjum Rubeena , Thakur Kalpna , Bhardwaj Nandini
Published: April 2023

Fungal infections have been commonly observed in the oral cavity with the most common being Candida albicans but with time, new species of candida have been observed and isolated from the oral cavity. Identification of new strains is necessary not only because of their ability to cause infection but also due to their susceptibility toward antifungal agents. The use of concentrated saliva or serial dilution method has been used for these culture tests, with each method having its own advantage and disadvantage. Hence, the aim of the study was to quantitatively analyze effectiveness of both these methods on samples from the oral cavity.
Comparative Pharmaceutico Analytical Study of Madhyama Paka and Khara paka in Sneha Paka WSR to Katupila Taila
Authors: Shah Samip , Bedarkar Prashant , Shukla V. J. , Patgiri B. J. , Mehul Mehul
Published: April 2023

Introduction: Different types of Snehapaka have been mentioned in Sarangdhar Samhita such as Mrudu Paka, Madhyama Paka, Khara Paka, Dagdha Paka, Ama Paka, and Gandha Paka. Further, different uses of sneha according to its paka had been mentioned in which Madhyama Paka and Khara Paka are stated to be used for internal (Pana) and external (Abhyang), respectively. Aim: The present study was carried out to discriminate type of paka in Katupila taila on the basis of classical and modern parameters, namely, Paka pariksha, organoleptic-physicochemical parameters, and chromatography. Results: Average 934.8 g (93.48% yield) and 845.33 g (84.53% yield) of Katupila Taila madhyama paka (KPTM) and Khara paka, respectively, was obtained from batch size of, 1 L of Tila Taila with 212 g of Kalka dravya and 4 L of Kwatha of Katupila stem. Temperature reached up to 92°C and 97°C, respectively, for completion of Madhyama Paka and Khara Paka. Heating was carried out for 3 consecutive days for both Paka. Discussion: Average duration between initiation of Madhyama Paka and end of Khara Paka was 1 h and 44 min. Here, temperature and duration of heating play a major role in the type of Paka. It showed difference in the values of physicochemical parameters of both Paka. KPTM and Khara paka were having specific gravity (0.9179 ± 0.0050 and 0.9294 ± 0.0067), refractive index (1.449 ± 0.009 and 1.474 ± 0.015), acid value (2.908 ± 0.0538 and 1.809 ± 0.0472), iodine value (108.075 ± 2.9793 and 72.875 ± 3.2548), saponification value (169.66 ± 8.9132 and 226.64 ± 6.1567), and BTTT value (19.6 ± 0.3, 28.5 ± 0.5), respectively.
Vegetarian Diets: Conceptualization Health Outcomes, Nutritional Concerns, and Explicit Features – An Indian Perspective
Authors: Kaur Harmeet , Aeri Bani Tamber
Published: April 2023

Vegetarian has its origin in the Latin word “vigitore” meaning “to give strength and health.” Modern concise Oxford dictionary defines a vegetarian to be “a person who doesn’t eat meat or fish for moral, religious, or health reasons.” Vegetarianism has very ancient roots and its history comprises many diverse characters and events. The practice has been apparent in many cultures all over the world. In Asia, particularly India, absenteeism from meat was the core of early religious philosophies such as Hinduism, Brahmanism, Zoroastrianism, and Jainism. With time and scientific advancements, there were a greater understanding and linking of vegetarian diets with health apart from its association with religion and spiritual contexts. There exist many differences between an Indian vegetarian diet and a Western vegetarian diet. Some of the prominent features of which are lower intake of fruits and vegetables, high-carbohydrate and high-glycemic diets, higher intake of milk and milk products, quality and nature of fat, and snacking behavior.
Protective Effects of Lantana camara (aculeata) in Rheumatoid arthritis using in vitro and in vivo Complete Freund’s Adjuvant induced arthritis in rats
Authors: Dhikale Rupali , Gulecha Vishal , Zalte Amar
Published: April 2023

The main objective of the present work is to evaluate the potential of Lantana camara (aculeata) for anti-arthritic activity using in vitro and in vivo study. L. camara is an important medicinal, ornamental, and essential oil-producing herb from family Verbenaceae. Different parts of L. camara have been used for the treatment of various human ailments such as itches, cuts, ulcers, swellings, bilious fever, eczema, tetanus, malaria, tumor, rheumatism, and headache. The anti-arthritic activities of pet ether, ethyl acetate, ethanol, and aqueous extracts of L. camara were initially evaluated using in vitro model of arthritis. The ethanolic and aqueous extracts were found to be better among all the extract in in vitro study and hence subjected for further in vivo anti-arthritic study using complete Freund’s adjuvant (CFA) model in rats for 28 days. Both the extracts at 200 and 400 mg/kg were evaluated in rats for different parameters. The paw volume displacement, changes in body weight, arthritic index, alteration in serum biomarker, alteration in hematological parameters, secondary lesions changes as noticed from the radiograph, and histopathology study were measured as a mark of antiarthritic activity. The results indicate that L. camara protects rats remarkably against the primary and secondary arthritic lesions, body weight changes, serum biomarker changes, radiological, histopathological, and hematological perturbations induced by CFA in dose-dependent manner. However, the effect of the ethanolic extract at the dose of 400 mg/kg was more significant, superior, and pronounced than aqueous extract and also it is comparable to the standard drug.
Identification of miRNA Biomarkers for Non-small Cell Lung Cancer using Microarray Datasets and Bioinformatics Analysis
Authors: Khan Imteyaz Ahmad , Sharma Srikant
Published: April 2023

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, which accounts for about 81% percent of all lung cancer cases. Despite advances in NSCLC diagnosis and treatment, the mortality rate is still high. Patients with NSCLC have a 5-year survival rate of only 21%. NSCLC is currently diagnosed at an advanced stage when cancer has already metastasized. Hence, it is essential to elucidate the molecular mechanisms associated with NSCLC pathogenesis and identify early diagnostic or predictive biomarkers. Circulating miRNAs might act as non-invasive blood-based biomarkers for NSCLC diagnosis and prognosis. In this study, we used previously published microarray datasets from Gene Expression Omnibus database and identified 12 down-regulated miRNAs in tissue and blood of NSCLC. Further analysis identified three miRNAs that could serve as biomarkers in the diagnosis of NSCLC: miR-140-3p, miR-29c, and miR-199a. The functional enrichment analysis of the candidate microRNA’s target genes disclosed various overrepresented pathways associated with malignancy progression. Seven target genes are identified as hub genes of the PPI network and hold strong predictive power. In addition, the three-gene combination (IL6, SNAI1, and CDK6) shows a hazard ratio of more than one (hr = 1.5) and P-value <0.002. Since the expression levels of these three miRNAs were significantly decreased in both tissue and blood, measuring miRNA expression in the blood also gives information on its expression in tissue. Therefore, these three microRNAs could be used as NSCLC diagnostic and prognostic biomarkers.
Genetics and Epigenetics Conceptual Study in View of Ayurveda
Authors: Chandurkar Nitin S. , Dahat Soniya , Gulhane Pavan
Published: April 2023

The current generation is concerned about lifestyle disorders and measures to maintain a healthy lifestyle. Individuals’ physical appearance, mental qualities, and illness creation are all influenced by genetic elements, according to modern science. Most diseases have a hereditary component, according to human genome studies. Genetic mutations can happen at random or as a result of an external cause. Genetic illnesses can be hereditary or not. Ayurveda is a historic Indian medical practice that dates back to the Vedic era. However, while the current knowledge of human genetics owes largely to Gregor Mendel’s work, a number of Indian writings have discussed the scientific concept of genetics before him. Although the name “genetics” was not used in Ayurveda, the concept of genetics is mentioned in several places throughout the traditional texts of Ayurveda, particularly in the Samhitas. The focus of the review is on Ayurveda’s therapeutic applications of genetics and to better understand Ayurvedic mechanisms through epigenetics.
Self-Esteem: A Study on Elite Para-Throwers of India
Authors: Singh Vikas , Singh Mahendra Kumar , Bhutia Tenzing Norzom
Published: April 2023

The degree of valuation and competency that we give to ourselves determines our self-esteem. We may boost our self-esteem by having a good perception of our bodies as well as the physical talents and abilities we develop through sports. We gain a sense of positive self-worth as a consequence of the praise we receive through family and friends, as well as the social bonds we form as a result of our participation in sports and physical activity. Self-esteem plays a key role in athletic performance and sporting success. In the past, studies have focused on the self-esteem concept of sports psychology in sports in elite athletes; however, there is little research on self-esteem in para-sports. This study aimed to examine the self-esteem of elite Indian para-throwers who participated at the international level. Based on this, the aim of this study was to investigate the mental self-esteem levels of elite Indian. The study group of the research consisted of 11 para-throwers (6 = standing thrower and 5 = seated thrower) who participated at the international level (Paralympic, World Championship, World Grand Prix) aged 18–40 years. Purposeful sampling approaches and easily accessible sampling methods were used in the selection of the study group. The scale form was used to collect research data. The study consisted of two parts. In the first part, of this form, there was a personal information form developed by the investigator to collect demographic information of athletes, and in the second part, there was the “Rosenberg Self-Esteem Scale” developed by Rosenberg (1965). After analysis of the data, it was found that there were no significant differences in self-esteem level at level 0.05 in both groups of para-throwers and most of the para-athletes found average on self-esteem concept.
Machine Learning Techniques for Automatic Detection of Sickle Cell Anemia using Adaptive Thresholding and Contour-based Segmentation Method
Authors: Patgiri Chayashree , Ganguly Amrita
Published: April 2023

Automatic diagnosis of diseases in the medical field using image processing techniques has evolved tremendously in recent times. Sickle cell anemia (SCA) is a kind of disease connected with red blood cells (RBCs) present in the human body in which deformation of cells take place. The purpose of this work is to propose an automatic image processing technique for the detection of this disease from microscopic blood images. This paper mainly focuses on automatic detection of SCA using a novel segmentation method encompassing local adaptive thresholding and active contour-based algorithm. For the detection of sickle cells, supervised classifiers such as Artificial Neural Network (ANN) and Support Vector Machine (SVM) are used. Here, geometric features of healthy and unhealthy RBCs are calculated and applied to these classifiers. In this approach, performance is found slightly greater in SVM classifier than the ANN classifier trained with scaled conjugate gradient back-propagation (BP) algorithm and with hidden layer of ten neurons. The proposed approach achieves a maximum of 99.2% accuracy with SVM classifier. The performance is also studied for seven different training algorithms in the ANN classifier by varying the numbers of hidden layer neurons. Comparative analysis of the performances of these algorithms shows that, resilient BP algorithm and 10 numbers of hidden neurons gave moderately better performance in ANN with 99% accuracy. ANN and SVM classifier with adaptive thresholding and active contour technique is an efficient approach for the classification of patients with SCA.
Development and Validation RP-HPLC Method for Simultaneous Estimation of Dapagliflozin and Saxagliptin in Bulk and Pharmaceutical Dosage Form
Authors: Nizamuddin Syed , Raju S. Appala
Published: April 2023

A simple, precise, sensitive, and rapid reverse phase high performance liquid chromatographic method was developed and validated for simultaneous estimation of Dapagliflozin (DAPA) and Saxagliptin (SAXA) in bulk as well as in tablet formulation according to the ICH guidelines. The chromatographic phase consisted by phosphate buffer: Acetonitrile, pH 4.0 adjusted by glacial acetic acid. The flow rate was adjusted to 0.8 ml/min and UV detection was carried out at 220 nm. Retention time was found to be 2.144 and 3.156 min; respectively. The detector was showed that linear responses over the concentration range 10–24 μg/ml for SAXA and 12–40 μg/ml for DAPA a good correlation coefficient of 0.999. This proposed method is highly sensitive, precise, and accurate which reduces cost of analysis; hence, recommended for routine quality analysis in laboratories.
Effect of Supplementation of Multigrain Laddo for Malnourished Children under 3–5 Years
Authors: Kumari Rosy , Bose Deepak
Published: April 2023

Malnutrition is one of the greatest single threats to the world’s public health among children in developing countries according to the World Health Organization. It affects the child at the most crucial period, that is, stage of development, which can lead to permanent impairment in later life which includes reduced work capacity, growth retardation, and poor social and mental development. Half of all child deaths in India could be prevented if this one issue is tackled. Almost 11 million children die before they reach the age of five, four million of them in the 1st month of life. It is a significant public health problem described as a silent killer, silent emergency and invisible enemy affecting those who cannot express their voice and have to depend on others for their advocacy. The main objective of this study is to determine the effect of supplementation with the selected product on the nutritional status of the selected malnourished children. A baseline survey was conducted in four villages of Allahabad District, U.P. A total number of 382 respondents were selected (187 girls and 195 boys) for the present study. They belong to age group of 3–5 years. Four products were prepared with the help of incorporation composite flour. For each product, the basic recipes (control T0) have three variations T1, T2, and T3, respectively, were incorporated at different levels. The products such as Laddo, Biscuit; Mathri, and Chakli were developed. After supplementation, it is evident to note that there was a statistically significant improvement at 1% level and it was observed in the experimental and there was no increment in the weight of the selected subjects in the control group.
Evaluation of Mast Cell Stabilizing, Anti-Inflammatory, and Anti-Oxidant Activity of Seed Extracts of Saraca Asoka (Roxb.), De. Wild
Authors: Ghante M. H. , Rathod C. P.
Published: April 2023

Saraca Asoka (Caesalpiniaceae) is a medicinal plant used traditionally for the treatment of various diseases. There is no scientific evidence for the anti-asthmatic activity of Saraca Asoka. Preliminary phytochemical screening of extract has revealed the presence various phytochemical components such as flavonoids, tannins, saponins, carbohydrates, phenols, glycosides, and fixed oils and fats. However, no alkaloids, proteins and amino acids were found in the extracts. The present study was evaluated for phytochemical screening, mast cell stabilizing, anti-inflammatory, and antioxidant activity of the methanolic extract of Saraca Asoka. In the present study, DPPH radical scavenging activity was highest in methanol extract (94.5 % ± 1.8%) of Saraca Asoka seeds. The in vivo anti-inflammatory activity was evaluated in rats using carrageenan-induced paw edema and in vitro antioxidant activity was performed by 1, 1-diphenyl-2-picryl-hydrazyl (DPPH) and ABTS. Quantitative estimation of total polyphenolic content of the (SA-ME) was estimated by Folin-Ciocalteu method. SA-ME (200 mg/kg body wt.) significantly decreased paw volume, after oral administration of SA-ME in carrageenan and formaldehyde injection. SA-ME also exhibit significant antioxidant activity. Total polyphenolic content was found to be (179 ± 0.27 mg/ml) and exhibited highest flavonoid content (8.42 ± 0.25 mg/ml). These results show that the methanol extract of Saraca Asoka seeds shows potential mast cell stabilizing, anti-inflammatory and anti-oxidant activity.
Mental Wellness of School Teachers Using Virual Pedagogy
Authors: Mishra Niharika , Agrawal Shalini , Sharmila Khwairakpam
Published: April 2023

Research Background: Mental wellness is an issue than a subject to talk over. Everything is getting established on e-stages, such as classes, meetings, and seminars. In addition of getting management of time and easier attention, there are lots of issues along with like as mental retardation of teachers. Methodology: An interview schedule along with the Hero mental wellness scale was used to collect the data. Descriptive research design and purposive sampling technique were used to select the sample for study. Major Findings: The study revealed that most of the respondents were having the extremely happy mental wellness. The study showed that there were no significant differences in mental wellness of respondents across different age group and gender. Conclusion: Major issues are mental health regarding such as migraine, anxiety, and insomnia which results in lack of sleep headache stress depression and several other related issues. Continuously facing the screens of mobile laptop and computers reasonable cause behind all these problems.
Prachhan Karma with Lepa and Shirodhara – An Effective Treatment of Indralupta – A Case Study
Authors: Londhe Snehal P. , Dharkar Nilima S. , Londhe Snehal P.
Published: April 2023

Hairs play an important role in personality and always remained the center of attraction. Beautiful hairs are considered as parameter of beauty, people are very conscious about hair, and they are always in search of good remedy for maintaining their hairs. Indralupta (Alopecia Areata) is acquired skin aliment that can affect all the hair bearing skin including scalp, beard which is characterized by localized areas of non-scarring hair loss which can be compared with Alopecia Areata. Hair loss is one of the most common problem people faces, the cause of being today’s lifestyle. The prevalence rate of Alopecia Areata is 0.7% in India.[1] Modern medication (steroids and minoxidil) has adverse effects such as drowsiness, dizziness, vomiting and continuous intake of steroid leads to diabetes, hypertension, and osteoporosis. Many curative and preventive steps are mentioned in Ayurveda by Acharya Sushruta such as Nasya (instillation of medicine by nostrils), Rasayana (path of essence), Murdha taila, Siravedha (bloodletting by puncturing), Prachhan, Lepan (pack), and Shiroabhyanga. Snehan (oil Massage), Swedan (sweating), Shaman, and Shodhana chikitsa told by Sushruta for Indralupta. Among these, Prachhan karma helps to stimulate the hair follicles. Prachhan karma (bloodletting by puncturing), followed by Lepa (pack) and Shirodhara (medicated liquid flow over head) with medicine having Keshya, Balya, and rejuvenating property gives good results in Indralupta. Due to limitation and side effects of minoxidil and steroids some safe and effectual medication from other medical science are expected. Here is a case of Indralupta (Alopecia Areata) successfully treated with Prachhan karma followed by Lepa and Shirodhara with Ayurvedic Medicine.
Plants Associated with Human Fertility and Child Birth in Una District of Himachal Pradesh (India)
Authors: Saini Jaswant Singh , Sankhyan Parveen
Published: April 2023

The Shivalik ranges divide the plain and Himalayan Mountain peaks and housed many medicinal important plants. One of the densely populated parts of this region includes district Una of Himachal Pradesh which has been thoroughly explored to identify the traditional knowledge in relation to plants associated with human fertility and childbirth-related problems in modern society. Infertility may account for many cases of “unexplained” fertility problems due to one or both partners. The present study revealed that people rely on total 24 plants species within 24 genera, belonging to 19 families that are utilized for various types of human fertility problems and child birth. Out of the total 19 family reported, the family Fabaceae leading with three species, followed by Lauraceae, Poaceae, and Zingiberaceae with two species each. The recorded species represent trees (11 species), shrubs (06), herbs (05), and climbers (02). The present information indicates the use of indigenous knowledge of the local people regarding the use of plant-based medicines to boost natural fertility, helps to maintain a healthy pregnancy, and is also recommended before and after parturition for easy delivery and will tone the uterus and nourish the blood.
Awareness and Attitudes toward COVID-19 Pandemic among Elderly Population of West Bengal
Authors: Dolai Mohan Chandra , Jana Sahana , Maiti Amit Kumar , Adak Amita , Alam S. K. Md. Murtaja , Mishra Nandini
Published: April 2023

Background: COVID-19 has emerged as a pandemic and it has had unprecedented negative impact on elderly population. A lack of awareness and poor understanding of the disease may result in rapid transmission of the disease. This study aimed to investigate the awareness and attitude toward COVID-19 among elderly population in West Bengal, India. Methods: This cross-sectional study was conducted with the help of an online questionnaire and sent to elderly population of West Bengal. The study comprised a series of questions regarding demography, family composition, awareness, attitudes, and practices as precautionary measures from COVID-19. Results: A total of 212 elderly respondents participated in this study comprising 55.66% of males and 44.34% are females. Overall 75.58 ± 3.21 respondents showed good knowledge and awareness about COVID-19. Avoiding social gathering (84.43%), preference to stay in home (76.89%), and wearing mask (74.06%) were the most common preventive measures taken by respondents that were followed using sanitizing (58.96%) and avoiding traveling (24.64%). Significantly more educated and employed respondents showed more considerable knowledge of the disease awareness. Conclusion: The study respondents showed adequate basic knowledge and awareness of COVID-19. There is a strong need to implement periodic educational interventions and training programs on infection control practices.
Sequel of Ficus racemosa Bark Decotion in Infected Wound care Intendence
Authors: Inamdar Farhin K. , Kukade Archana , Babar Sanjay
Published: April 2023

Ayurveda is historic science having global scope in preventive as well as curative fitness care.in Shayla Tantra Vrana is maximum important factor of pores and skin whether or not shuddha Vrana, sadyo Vrana, and dushta Vrana in Ayurveda its certainly approved that if shuddha Vrana is left untreated then it is directed to dushta vrana so complete measures are taken for Vrana ropana. The destruction/spoil/rupture/discontinuity of body tissue/a part of frame is known as vrana.Vrana having dushta involvement is dushta vrana it actually Compromise of awful ulcer, offensive infected wound. Next are signal and signs and symptoms of dushta vrana ganda (mal-odour), kandu (itching), vedana (ache) taal (floor of the wound), Varna Varna (coloration), vrana strava (discharge) so in this situation series report a set of 5 instances ofwound had been decided on, between age institution of 20–30 years, having a such grievance have been treated with udumber kwathdressing for 15 days. On the end of the remedy by way of udumber kwath dressing patient got good sized development is symptoms. Ayurveda interpreted diverse remedy strategies for the control of sickness use of herbs Ayurveda formula and Kashaya and so on. Those case examine offered on dushta vrana.
Formulation and Evaluation of Solid Dispersion of Celecoxib
Authors: Chauhan Sunil , Adhikari Anupriya , Patil Shivanand
Published: April 2023

The aim of this study was to develop celecoxib (CLX) -polyvinylpyrrolidone (PVP) solid dispersion nanoparticles with and without surfactant using the supercritical antisolvent (SAS) process. The effect of different surfactants such as gelucire 44/14, poloxamer 188, poloxamer 407, Ryoto sugar ester L1695, and D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) on nanoparticle formation and dissolution as well as oral absorption of CLX -PVP K30 solid dispersion nanoparticles was investigated. Spherical CLX solid dispersion nanoparticles <300 nm in size were successfully developed using the SAS process. Analysis by differential scanning calorimetry and powder X-ray diffraction showed that CLX existed in the amorphous form within the solid dispersion nanoparticles fabricated using the SAS process. The CLX -PVPTPGS solid dispersion nanoparticles significantly enhanced in vitro dissolution and oral absorption of CLX relative to that of the unprocessed form. The area under the concentration-time curve (AUC0 24 h) and peak plasma concentration (Cmax) increased 4.6 and 5.7 times, respectively, with the CLX -PVP-TPGS formulation. In addition, in vitro dissolution efficiency was well correlated with in vivo pharmacokinetic parameters. The present study demonstrated that formulation of CLX -PVP-TPGS solid dispersion nanoparticles using the SAS process is a highly effective strategy for enhancing the bioavailability of poorly water-soluble CLX.
Understanding Amblyopia in Ayurveda Perspective: A Review Article
Authors: Singh Abhishek , Fiaz Shamsa , Gadadi Malashree S.
Published: April 2023

Vision is prime sense to have facile life and abnormalities of vision are very common in all populations with various pathologies in different parts of eye such as cornea, lens, and vitreous retina. Amblyopia is one such condition which is characterized by reversible loss of vision affecting one or both the eyes. Examination is important to rule out any organic defect in various parts of the eye. In Ayurveda, many of the visual differences are coined under the heading of Timira which is characterized by blurred vision. The Vataja Timira symptoms can be correlated to Amblyopia hence the management.
Candida: A Clinico-mycological Study
Authors: Sharma Anuradha , Mehta Preeti , Sharma Aditi
Published: April 2023

Fungal infections caused by Candida spp. are a cause of morbidity and mortality, with Candida albicans being considered the prime suspect. Other species, Candida tropicalis, Candida pseudotropicalis, Candida parapsilosis, Candida krusei, Candida guilliermondii, and Candida vishwanathii are equally notorious and should be reported aggressively. The presence of fungal elements in clinical samples is sometimes low, making their detection challenging amidst the tissue elements and other bacterial presence. Therefore, mycological diagnostic methods need to be comprehensive with no less emphasis on any diagnostic step.
A Comparative Clinical Study of Kanchanar Guggulu and Varuna Shigru Guggulu along with Bala Taila Matra Basti in the Management of Mootraghata w.s.r. to Benign Prostatic Hyperplasia
Authors: Chauhan Priyanka , Dudhamal T. S. , Sonani Snehal , Ghoniya Priyal
Published: April 2023

Background: Benign prostatic hyperplasia (BPH) is a benign enlargement of prostate gland commonly found in elderly men (50% found above 40 year of age) and responsible for major affecting factor for quality of life. The overall incidence rate of BPH is 15/1000 men per year. The present treatment modalities have their own complication and limitations. Hence, here is a need to approach a treatment aspect which can minimize the complication along with major relief effect. According to Ayurveda, considering Vata dosha (ApanaVata) as a main culprit for BPH/Mootraghata, line of treatment was planned to evaluate and compare the clinical efficacy of Kanchanar Guggulu and Varuna Shigru Guggulu, along with Matra basti of Bala Taila svata-kaphahar, mutrakrichahara, Lekhan, and shothahara along with oral medication. Materials and Methods: The patients having signs and symptoms of Mootraghata/BPH were registered and allocated into two groups by computer generated randomization method. Patients were treated with Kanchanar Guggulu orally (1 g thrice a day) in Group A (n = 40) and (1 g thrice a day) Group B (n = 41) for 21 days. Matra basti with 60 ml Bala Taila once a day was given in both groups for 21 days. Results: The result was drawn using appropriate statistical testes in objective as well subjective parameters and also to compare efficacy of both group treatment modalities. The trial drug depicted highly significant results in international prostate symptoms score (IPSS) symptoms, average urine flow rate and prostate size, and post-void residual urine (PVRU) in Group A, whereas Group B possessed highly significant effect on all the mentioned IPSS symptoms with improvement in the QOL, but significant changes were observed in PVRU. Conclusion: Final study concluded that Kanchanar Guggulu and Varuna Shigru Guggulu orally along with Bala Taila Matra bastiis safe and effective in the management of Mootraghata (BPH).
Assessment of Post-COVID Syndrome Manifestations among COVID-19 Subjects in Kannur District of Kerala
Authors: Poojara Rashmi H. , Sebastian Jesnet , George Feba , Salam Sana Fathima
Published: April 2023

A 6-month community-based, prospective, and cohort study was conducted among 250 post-COVID subjects in Kannur district of Kerala by assessing dietary diversity score (DDS), comorbidities, symptoms during COVID and post-COVID, fatigue, stress, and insomnia. Out of the 250 patients, 47.2% were male and 52.8% were female and 48% belonged to the 18–29-year age group. Among the patients, 22% had a high DDS. The most common comorbidities observed were hypertension (26%), followed by diabetes mellitus (23.2%) and cardiovascular disease (15.2%). During the period of infection, the most common symptom among patients was the loss of appetite (93.2%), followed by dry cough (92.4%) and tiredness (92%). Headache (92%) and breathlessness (90%) were the other significant symptoms. The most prevalent post-COVID symptoms were breathing difficulty (94.4%), joint pain 92.4%), (weakness (89.2%), and abdominal pain (87.2%). During COVID, 21.6% of the patients were severely fatigued, 48.8% of the patients had a moderate level of perceived stress, and 38% of the patients had subthreshold insomnia. During post-COVID, 56.8% were severely fatigued; moderate stress was found in 53.2%, of the subjects; and 56% of the study subjects had subthreshold insomnia. Through analysis of variance analysis, it is concluded that exercise has an impact on fatigue, stress level, diet pattern, and sleep pattern. Using Karl Pearson correlation coefficient of different parameters, the positively correlated variables were sleep and fatigue, sleep and stress, and stress and fatigue. The prevalence of new-onset fatigue, perceived stress, and insomnia was significant among COVID-19 survivors.
An Ocular Route of Administration for Drugs through Novel Approach of Self-microemulsifying Formulation – A Systematic Review
Authors: Kulkarni Nilesh S. , Indore Pratiksha , Godase Sonam , Shinde Priyanka , Prabhune Puja
Published: April 2023

Drug administration through ocular route is associated to treat the ophthalmic diseases; glaucoma, conjunctivitis, retinal disorder, and diabetic eye problems. Various ophthalmic formulations as nanoparticles, nanoemulsion, microemulsion, nanosphere, microsphere, and nanosuspension have been developed. Such novel formulations have ability to prolonged the contact time of dosage form on ocular surface and reduce the drug elimination. Microemulsion is the thermodynamically stable and clear dispersion of oil and aqueous phase stabilized by surfactant and cosurfactant with target droplet size up to100 nm. Self-microemulsifying drug delivery system (SMEDDS) approach is generally adopted to enhance bioavailability of poorly water-soluble drugs. SMEDDS is the appropriate system for ocular drug delivery as it improves the ocular drug retention, high ocular absorption, and extended duration of action. The surfactant/cosurfactant combination used in SMEDDS has capacity to improve drug permeation across the cornea. The review gives the highlights to understand the feasibility of SMEDDS as dosage form for ocular administration to increases or improve the bioavailability. Review highlights the developmental steps of SMEDDS for the ocular drug administration as novel dosage forms to improve patient compliance.
Comparative Study between Hyaluronic Acid and Fat in Rhinoplasty: A Systematic Review
Authors: Mowar Apoorva , Dubey Prajesh , Gupta Nitish , Pandey Swati , Sharma Shelly , Panwar Shreya
Published: April 2023

The aim of this article is to provide high-quality evidence on patient satisfaction and complications of two non-surgical rhinoplasty procedures. All available online literature up to 2021 were searched utilizing keywords and MESH search phrases also used in the online databases. In addition, the reference lists of the systematic reviews included in the study were manually searched. The studies with greatest evidence were included to assess patient satisfaction and complication. Critical evaluation of the articles was done and MINORS scale was used for bias determination. Temporary redness in the skin, fluid accumulation, discoloration of skin, and post-procedure discomfort were all transient problems in all of the investigations. Vascular limitations and hematoma were identified as rare consequences. Non-surgical rhinoplasty treatments are both a good and less intrusive alternative to traditional rhinoplasty. However, there is a scarcity of experimental and prospective studies, so more number of trials to be carried out to determine the precision, efficacy, and adverse effects of non-surgical rhinoplasty.
Water distribution network leak localization with histogram-based gradient boosting
Authors: Marvin Gabriel , Grbčić Luka , Družeta Siniša , Kranjčević Lado
Published: April 2023

Accurate and rapid leak localization in water distribution networks is extremely important as it prevents further loss of water and reduces water scarcity. A framework for identifying relevant leak event parameters such as the leak location, leakage area, and start time is presented in this paper. Firstly, the proposed data-driven methodology consists of acquiring pressure data at nodes in the network through hydraulic simulations by randomly changing the leak event initial conditions (leak location, area, and start time). Pressure uncertainties are added to the sensor measurements in order to make the problem more realistic. Secondly, the acquired data are then used to train, test, and validate a machine learning model in order to predict the relevant parameters. The random forest and the histogram-based gradient boosting machine learning algorithms are investigated and compared for the leak detection problem. The proposed approach with the histogram-based gradient boosting algorithm shows high accuracy in predicting the true leak location.