bluuebunny/crossref_metadata_2025 huggingface dataset:
Oyster Shell Powder, Zeolite and Red Mud as Binders for Immobilising Toxic Metals in Fine Granular Contaminated Soils (from Industrial Zones in South Korea)
Authors: Torres-Quiroz Cecilia , Dissanayake Janith , Park Junboum
Published: March 2021

Low-cost absorbent materials have elicited the attention of researchers as binders for the stabilisation/solidification technique. As, there is a no comprehensive study, the authors of this paper investigated the performance of Oyster shell powder (OS), zeolite (Z), and red mud (RM) in stabilising heavy metals in three types of heavy metal-contaminated soils by using toxicity characteristic leaching procedure (TCLP). Samples were collected from surroundings of an abandoned metal mine site and from military service zone. Furthermore, a Pb-contaminated soil was artificially prepared to evaluate each binder (100× regulatory level for Pb). OS bound approximately 82% of Pb and 78% of Cu in real cases scenario. While Z was highly effective in stabilizing Pb in highly polluted artificial soil (>50% of Pb) at lower dosages than OS and RM, it was not effective in stabilising those metals in the soils obtained from the contaminated sites. RM did not perform consistently stabilising toxic metals in soils from contaminated sites, but it demonstrated a remarkable Pb-immobilisation under dosages over than 5% in the artificial soil. Further, authors observed that OS removal efficiency reached up to 94% after 10 days. The results suggest that OS is the best low-cost adsorbent material to stabilize soils contaminated with toxic metals considered in the study.
Thermal Discomfort Levels, Building Design Concepts, and Some Heat Mitigation Strategies in Low-Income Communities of a South Asian City
Authors: Ehsan Sana , Abbas Farhat , Ibrahim Muhammad , Ahmad Bashir , Farooque Aitazaz A.
Published: March 2021

Heat stress provokes thermal discomfort to people living in semiarid and arid climates. This study evaluates thermal discomfort levels, building design concepts, and some heat mitigation strategies in low-income neighborhoods of Faisalabad, Pakistan. The outdoor and indoor weather data are collected from April to August 2016 using a weather station installed ad hoc in urban settings, and the 52 houses of the five low-income participating communities living in congested and less environment-friendly areas of Faisalabad. The discomfort index values, related to the building design concepts, including (i) house orientation to sunlight and (ii) house ventilation, are calculated from outdoor and indoor dry-bulb and wet-bulb temperatures. Our results show that although June was the hottest month of summer 2016, based on the monthly mean temperature of the Faisalabad region, the month of May produced the highest discomfort levels, which were higher in houses exposed to sunlight and without ventilation. The study also identifies some popular heat mitigation strategies adopted by the five participating low-income communities during various heat-related health complaints. The strategies are gender-biased and have medical, cultural/customary backgrounds. For example, about 52% of the males and 28% of the females drank more water during dehydration, diarrhea, and eye infection. Over 11% and 19% of the males and females, respectively, moved to cooler places during fever. About 43% of the males and 51% of the females took water showers and rested to combat flu (runny nose), headache, and nosebleed. The people did not know how to cure muscular fatigue, skin allergy (from a type of Milia), and mild temperature. Planting trees in an area and developing open parks with greenery and thick canopy trees can be beneficial for neighborhoods resembling those evaluated in this study.
Sexual Function and Sexual Quality of Life in Premenopausal Women with Controlled Type 1 and 2 Diabetes—Preliminary Study
Authors: Bąk Ewelina , Młynarska Agnieszka , Sternal Danuta , Kadłubowska Monika , Marcisz-Dyla Ewa , Marcisz Czesław
Published: March 2021

Sexual dysfunction is more common in women with diabetes than in women without diabetes. The aim of the study was to determine sexual function and the level of the quality of sex life in premenopausal women with controlled, uncomplicated type 1 and type 2 diabetes taking into account the stages of the menstrual cycle and mood level. The study included 163 women with type 1 and type 2 diabetes and 115 controls without diabetes. Questionnaire studies were conducted using the following surveys: Demographic and Clinical Data Survey, Female Sexual Function Index, Sexual Quality of Life—Female, and Beck Depression Inventory. Both phases of the menstrual cycle—follicular and luteal—were included. It was shown that, in women with type 1 diabetes, sexual function decreased during the luteal phase in comparison with the follicular phase (p < 0.001). In the women with type 2 diabetes and in the controls, sexual function was comparable during both phases of the cycle (p > 0.05). In the women with uncomplicated controlled type 1 diabetes, sexual function and the sexual and relationship satisfaction changed depending on the phase of the menstrual cycle with a decrease during the luteal phase. Sexual function and the quality of the sex life of premenopausal women with controlled type 2 diabetes were comparable during both the follicular and the luteal phases. Sexual function in menstruating women with controlled type 2 diabetes decreased with age and a worsening mood.
Use of Starter Cultures in Foods from Animal Origin to Improve Their Safety
Authors: García-Díez Juan , Saraiva Cristina
Published: March 2021

Starter cultures can be defined as preparations with a large number of cells that include a single type or a mixture of two or more microorganisms that are added to foods in order to take advantage of the compounds or products derived from their metabolism or enzymatic activity. In foods from animal origin, starter cultures are widely used in the dairy industry for cheese, yogurt and other fermented dairy products, in the meat industry, mainly for sausage manufacture, and in the fishery industry for fermented fish products. Usually, microorganisms selected as starter culture are isolated from the native microbiota of traditional products since they are well adapted to the environmental conditions of food processing and are responsible to confer specific appearance, texture, aroma and flavour characteristics. The main function of starter cultures used in food from animal origin, mainly represented by lactic acid bacteria, consists in the rapid production of lactic acid, which causes a reduction in pH, inhibiting the growth of pathogenic and spoilage microorganisms, increasing the shelf-life of fermented foods. Also, production of other metabolites (e.g., lactic acid, acetic acid, propionic acid, benzoic acid, hydrogen peroxide or bacteriocins) improves the safety of foods. Since starter cultures have become the predominant microbiota, it allows food processors to control the fermentation processes, excluding the undesirable flora and decreasing hygienic and manufacturing risks due to deficiencies of microbial origin. Also, stater cultures play an important role in the chemical safety of fermented foods by reduction of biogenic amine and polycyclic aromatic hydrocarbons contents. The present review discusses how starter cultures contribute to improve the microbiological and chemical safety in products of animal origin, namely meat, dairy and fishery products.
Twin-To-Twin Transfusion Syndrome Donor and Recipient and Their Subsequent Cognitive Functioning in Late Childhood as Juvenile Athletes—A Case Study
Authors: Bidzan-Bluma Ilona
Published: March 2021

Objective: It is estimated that twin-to-twin transfusion syndrome (TTTS) occurs in 10–15% of monochorionic twin pregnancies. One of the fetuses takes on the role of donor and the other of recipient. The treatment administered involves serial amnioreduction and laser photocoagulation of the communicating blood vessels. After TTTS, children may have deficiencies in psychomotor functioning, in particular in cognitive functions, expressive language, and motor skills. Few scientific reports indicate that twins after TTTS do not demonstrate significant differences in tests which measure intellectual functioning. Methods: The cognitive functioning of twins in the late childhood period was compared using the following tools: an analysis of their medical history, an interview with their parents, and neuropsychological tests allowing the evaluation of their whole profile of cognitive functions. Case Study: Cognitive functioning in the late childhood period was analyzed in a pair of 11-year-old male twins (juvenile athletes), a donor and a recipient, who had developed TTTS syndrome in the prenatal period. Results: Comparison of the cognitive functioning profile of the donor and recipient revealed that children with a history of TTTS develop normally in terms of cognitive and motor functioning in late childhood. A comparative analysis of the donor and recipient was more favorable for the recipient, who had a higher level of general intelligence, visual–motor memory, and semantic fluency. Conclusions: The fact that both the donor and the recipient chose to pursue athletics suggests that gross motor skills are their strongest suit. Playing sports as a method of rehabilitation of cognitive function of children born prematurely after TTTS could contribute to the improvement of cognitive functioning.
Predicting the Severity of Parkinson’s Disease Dementia by Assessing the Neuropsychiatric Symptoms with an SVM Regression Model
Authors: Byeon Haewon
Published: March 2021

In this study, we measured the convergence rate using the mean-squared error (MSE) of the standardized neuropsychological test to determine the severity of Parkinson’s disease dementia (PDD), which is based on support vector machine (SVM) regression (SVR) and present baseline data in order to develop a model to predict the severity of PDD. We analyzed 328 individuals with PDD who were 60 years or older. To identify the SVR with the best prediction power, we compared the classification performance (convergence rate) of eight SVR models (Eps-SVR and Nu-SVR with four kernel functions (a radial basis function (RBF), linear algorithm, polynomial algorithm, and sigmoid)). Among the eight models, the MSE of Nu-SVR-RBF was the lowest (0.078), with the highest convergence rate, whereas the MSE of Eps-SVR-sigmoid was 0.110, with the lowest convergence rate. The results of this study imply that this approach could be useful for measuring the severity of dementia by comprehensively examining axial atypical features, the Korean instrumental activities of daily living (K-IADL), changes in rapid eye movement sleep behavior disorder (RBD), etc. for optimal intervention and caring of the elderly living alone or patients with PDD residing in medically vulnerable areas.
COVID-19 Confinement and Sexual Activity in Spain: A Cross-Sectional Study
Authors: López-Bueno Rubén , López-Sánchez Guillermo F. , Gil-Salmerón Alejandro , Grabovac Igor , Tully Mark A. , Casaña José , Smith Lee
Published: March 2021

Restrictions of free movement have been proven effective in tackling the spread of COVID-19 disease. However, sensitive populations submitted to longer periods of restrictions may experience detrimental effects in significant areas of their lifestyle, such as sexual activity. This study examines sexual activity during the COVID-19 confinement in Spain. A survey distributed through an institutional social media profile served to collect data, whereas chi-squared tests, t-tests, analyses of variance, and multiple logistic regression analysis were used to assess differences among sample subgroups. A total of 71.3% adults (N = 536) (72.8% female) reported engaging in sexual activity with a weekly average of 2.39 times (SD = 1.80), with significant differences favoring males, middle age, married/in a domestic relationship (p < 0.001), employed (p < 0.005), medium–high annual household income, living outside the Iberian Peninsula, and smoking and alcohol consumption. Analyses adjusted for the complete set of control variables showed significant odds for a lower prevalence of weekly sexual activity in women (OR = 0.44, 95% CI 0.27–0.72). Interventions to promote sexual activity in confined Spanish adults may focus on groups with lower sexual activity.
Effects of Speciation, Cooking and Changes in Bioaccessibility on Methylmercury Exposure Assessment for Contrasting Diets of Fish and Marine Mammals
Authors: Charette Tania , Kaminski Gregory , Rosabal Maikel , Amyot Marc
Published: March 2021

Uptake of the neurotoxicant monomethylmercury (MeHg) from fish and marine mammals continues to present a public health concern in Canada and elsewhere. However, fish and marine mammals are key diet items contributing to food security for some Indigenous populations in Canada. Mercury (Hg) exposure is estimated assuming that 100% of Hg is methylated, that 100% will be absorbed by the consumer and that cooking does not affect MeHg concentrations. Some of these assumptions do not correspond to our current state of knowledge. The aim of this study was to assess the impact of additional variables on Hg exposure equation using probabilistic risk analysis. New variables tested were (1) the proportion of methylated Hg compared to total Hg (pMeHg, %), (2) the relative absorption factor (RAF, %) expressed as bioaccessibility and (3) the mass loss factor (MLF, unitless) that represents the loss of moisture during cooking, known to increase MeHg concentration in fish and mammals. For the new variables, data from literature were used in order to set point estimate values that were further used in the probabilistic risk analysis. Modelling results for both fish and marine mammals indicate that adding these new variables significantly influenced estimates of MeHg exposure (Mood’s median test, p < 0.05). This study highlights that the evaluation of exposure to MeHg is sensitive to pMeHg, RAF and MLF, and the inclusion of these variables in risk assessment should be considered with care. Further research is needed to provide better food-dependent, population-specific estimates of RAF and MLF before formal inclusion in exposure estimates.
Occupational Exposure in the Lombardy Region (Italy) to SARS-CoV-2 Infection: Results from the MUSTANG–OCCUPATION–COVID-19 Study
Authors: Della Valle Paola , Fabbri Marco , Madotto Fabiana , Ferrara Pietro , Cozzolino Paolo , Calabretto Elisabetta , D’Orso Marco , Longhi Ermanno , Polosa Riccardo , Riva Michele , Mazzaglia Giampiero , Sommese Carmen , Mantovani Lorenzo ,   The MUSTANG–OCCUPATION–COVID-19 Study Group
Published: March 2021

Sero-epidemiological surveys are valuable attempts to estimate the circulation of SARS-CoV-2 in general or selected populations. Within this context, a prospective observational study was conducted to estimate the prevalence and persistence of SARS-CoV-2 antibodies in different categories of workers and factors associated with positivity, through the detection of virus-specific immunoglobulin G and M (IgG/IgM) in serum samples. Enrollees were divided in low exposure and medium-high groups on the basis of their work activity. Antibody responders were re-contacted after 3 months for the follow-up. Of 2255 sampled workers, 4.8% tested positive for SARS-CoV-2 IgG/IgM antibodies, with 81.7% to IgG only. Workers who continued to go to their place of work, were healthcare workers, or experienced at least one COVID-19-related symptom were more likely to test positive for SARS-CoV-2 antibodies. SARS-CoV-2 antibodies prevalence was significantly higher in the medium-high risk vs. low-risk group (7.2% vs. 3.0%, p < 0.0001). At 3-month follow-up, 81.3% of subjects still had antibody response. This study provided important information of SARS-CoV-2 infection prevalence among workers in northern Italy, where the impact of COVID-19 was particularly intense. The presented surveillance data give a contribution to refine current estimates of the disease burden expected from the SARS-CoV-2.
Mapping Risk of Malaria as a Function of Anthropic and Environmental Conditions in Sussundenga Village, Mozambique
Authors: Ferrão João L. , Earland Dominique , Novela Anísio , Mendes Roberto , Ballat Marcos F. , Tungaza Alberto , Searle Kelly M.
Published: March 2021

Mozambique is a country in Southern Africa with around 30 million inhabitants. Malaria is the leading cause of mortality in the country. According to the WHO, Mozambique has the third highest number of malaria cases in the world, representing approximately 5% of the world total cases. Sussundenga District has the highest incidence in the Manica province and environmental conditions are the major contributor to malaria transmission. There is a lack of malaria risk maps to inform transmission dynamics in Sussundenga village. This study develops a malaria risk map for Sussundenga Village in Mozambique and identifies high risk areas to inform on appropriate malaria control and eradication efforts. One hundred houses were randomly sampled and tested for malaria in Sussundenga Rural Municipality. To construct the map, a spatial conceptual model was used to estimate risk areas using ten environmental and anthropic factors. Data from Worldclim, 30 × 30 Landsat images were used, and layers were produced in a raster data set. Layers between class values were compared by assigning numerical values to the classes within each layer of the map with equal rank. Data set input was classified, using diverse weights depending on their appropriateness. The reclassified data outputs were combined after reclassification. The map indicated a high risk for malaria in the northeast and southeast, that is, the neighborhoods of Nhamazara, Nhamarenza, and Unidade. The central eastern areas, that is, 25 de Junho, 1 and 2, 7 de Abril, and Chicueu presented a moderate risk. In Sussundenga village there was 92% moderate and 8% high risk. High malaria risk areas are most often located in densely populated areas and areas close to water bodies. The relevant findings of this study can inform on effective malaria interventions.
Preventive Behavioral Insights for Emerging Adults: A Survey during the COVID-19 Pandemic
Authors: Park Sunhee , Kim Beomsoo , Kim Kyoung A.
Published: March 2021

Emerging adulthood is an important period for establishing health behavior patterns in life. This study aimed to examine factors related to preventive behaviors of emerging adults during the COVID-19 pandemic. A descriptive online survey design was used. Data were collected using a self-administrated, 28-item questionnaire completed by 239 undergraduate students from a university in Seoul, South Korea. The questionnaire was developed based on previous studies and the guidelines of the World Health Organization about COVID-19 preventive behaviors. The mean age of participants was 21.97 years, and the average score for COVID-19 preventive behaviors was 4.13 (SD: ±0.42) on a 5-point scale. Hierarchical regression analyses revealed that subjective norms related to parents (β = 0.425, p < 0.001), issue involvement related to COVID-19 (β = 0.160, p = 0.024), and sex (β = 0.137, p = 0.029) were significant factors related to preventive behaviors of emerging adults after controlling for demographic characteristics. The variables explained 20.1% of the variance in preventive behaviors. The results of this study suggest that better strategies for subjective norms related to parents and issue involvement related to COVID-19 must be considered to improve emerging adults’ preventive behaviors.
Understanding Period Poverty: Socio-Economic Inequalities in Menstrual Hygiene Management in Eight Low- and Middle-Income Countries
Authors: Rossouw Laura , Ross Hana
Published: March 2021

Menstrual hygiene management and health is increasingly gaining policy importance in a bid to promote dignity, gender equality and reproductive health. Effective and adequate menstrual hygiene management requires women and girls to have access to their menstrual health materials and products of choice, but also extends into having private, clean and safe spaces for using these materials. The paper provides empirical evidence of the inequality in menstrual hygiene management in Kinshasa (DRC), Ethiopia, Ghana, Kenya, Rajasthan (India), Indonesia, Nigeria and Uganda using concentration indices and decomposition methods. There is consistent evidence of wealth-related inequality in the conditions of menstrual hygiene management spaces as well as access to sanitary pads across all countries. Wealth, education, the rural-urban divide and infrastructural limitations of the household are major contributors to these inequalities. While wealth is identified as one of the key drivers of unequal access to menstrual hygiene management, other socio-economic, environmental and household factors require urgent policy attention. This specifically includes the lack of safe MHM spaces which threaten the health and dignity of women and girls.
A Study of Optimal Specifications for Light Shelves with Photovoltaic Modules to Improve Indoor Comfort and Save Building Energy
Authors: Lee Heangwoo , Zhao Xiaolong , Seo Janghoo
Published: March 2021

Recent studies on light shelves found that building energy efficiency could be maximized by applying photovoltaic (PV) modules to light shelf reflectors. Although PV modules generate a substantial amount of heat and change the consumption of indoor heating and cooling energy, performance evaluations carried out thus far have not considered these factors. This study validated the effectiveness of PV module light shelves and determined optimal specifications while considering heating and cooling energy savings. A full-scale testbed was built to evaluate performance according to light shelf variables. The uniformity ratio was found to improve according to the light shelf angle value and decreased as the PV module installation area increased. It was determined that PV modules should be considered in the design of light shelves as their daylighting and concentration efficiency change according to their angles. PV modules installed on light shelves were also found to change the indoor cooling and heating environment; the degree of such change increased as the area of the PV module increased. Lastly, light shelf specifications for reducing building energy, including heating and cooling energy, were not found to apply to PV modules since PV modules on light shelf reflectors increase building energy consumption.
A Model-Based Meta-Analysis of Willingness to Participate in Cancer Screening
Authors: Feng Guangchao Charles , Lin Zhiliang , Ou Wanhua , Su Xianglin , Yan Qing
Published: March 2021

Although early screening tests are beneficial for the detection and treatment of cancers, many people have failed to participate in screening tests. The present study aims to explore the theoretical underpinning of low participation in screening programs using the method of meta-analytic structural equation modeling. It was found that the health belief model is the most adopted theoretical framework. Moreover, the intended uptake of screening was positively predicted only by cues to action, health literacy, and perceived susceptibility. As a result, a health intention model, including the three significant variables, is proposed. The practical implications of the findings are that health communication campaigns should focus on enlightening and engaging the public through all necessary means to raise awareness and transfer knowledge in relation to screening procedures as well as cancers per se.
Impact of COVID-19 Restrictions on Western Australian Children’s Physical Activity and Screen Time
Authors: Nathan Andrea , George Phoebe , Ng Michelle , Wenden Elizabeth , Bai Pulan , Phiri Zino , Christian Hayley
Published: March 2021

Physical activity is essential for children’s healthy development, yet COVID-19 physical distancing restrictions such as school closures and staying at home, playground closures, and the cancelling of organised community sport have dramatically altered children’s opportunities to be physically active. This study describes changes in levels of physical activity and screen time from February 2020 (i.e., before COVID-19 restrictions were introduced in Western Australia) to May 2020 (i.e., when COVID-19 restrictions were in place). Parents of children aged 5 to 9 years from Western Australia were eligible to participate and recruited through convenience sampling. An online survey instrument that included validated measures of their children’s physical activity (unstructured, organized, home-based, indoor/outdoor active play, dog play/walking), sociodemographic, and other potential confounders was administered to parents. Paired t-tests and mixed ANOVA models assessed changes in physical activity outcomes. The analytic sample comprised parents of 157 children who were 6.9 years of age (SD = 1.7) on average. Overall, weekly minutes of total physical activity (PA) did not change from before to during COVID-19. However, frequency and duration (total and home-based) of unstructured physical activity significantly increased. Outdoor play in the yard or street around the house, outdoor play in the park or playground or outdoor recreation area, and active indoor play at home all significantly increased. Frequency and total duration of organised physical activity significantly declined during COVID-19 distancing. During Western Australian COVID-19 restrictions, there was an increase in young children’s unstructured physical activity and outdoor play and a decrease in organised physical activity. It remains to be seen whether children’s increased physical activity has been sustained with the easing of physical distancing restrictions.
Development of Machine Learning Models for Prediction of Smoking Cessation Outcome
Authors: Lai Cheng-Chien , Huang Wei-Hsin , Chang Betty Chia-Chen , Hwang Lee-Ching
Published: March 2021

Predictors for success in smoking cessation have been studied, but a prediction model capable of providing a success rate for each patient attempting to quit smoking is still lacking. The aim of this study is to develop prediction models using machine learning algorithms to predict the outcome of smoking cessation. Data was acquired from patients underwent smoking cessation program at one medical center in Northern Taiwan. A total of 4875 enrollments fulfilled our inclusion criteria. Models with artificial neural network (ANN), support vector machine (SVM), random forest (RF), logistic regression (LoR), k-nearest neighbor (KNN), classification and regression tree (CART), and naïve Bayes (NB) were trained to predict the final smoking status of the patients in a six-month period. Sensitivity, specificity, accuracy, and area under receiver operating characteristic (ROC) curve (AUC or ROC value) were used to determine the performance of the models. We adopted the ANN model which reached a slightly better performance, with a sensitivity of 0.704, a specificity of 0.567, an accuracy of 0.640, and an ROC value of 0.660 (95% confidence interval (CI): 0.617–0.702) for prediction in smoking cessation outcome. A predictive model for smoking cessation was constructed. The model could aid in providing the predicted success rate for all smokers. It also had the potential to achieve personalized and precision medicine for treatment of smoking cessation.
A Cross-Country Examination on the Fear of COVID-19 and the Sense of Loneliness during the First Wave of COVID-19 Outbreak
Authors: Lo Coco Gianluca , Gentile Ambra , Bosnar Ksenija , Milovanović Ivana , Bianco Antonino , Drid Patrik , Pišot Saša
Published: March 2021

The aim of the current study is to examine gender, age. and cross-country differences in fear of COVID-19 and sense of loneliness during the lockdown, by comparing people from those countries with a high rate of infections and deaths (e.g., Spain and Italy) and from countries with a mild spread of infection (e.g., Croatia, Serbia, Slovakia, Slovenia, and Bosnia and Herzegovina). A total of 3876 participants (63% female) completed an online survey on “Everyday life practices in COVID-19 time” in April 2020, including measures of fear of COVID-19 and loneliness. Males and females of all age groups in countries suffering from the powerful impact of the COVID-19 pandemic reported greater fear of COVID-19 and sense of loneliness. In less endangered countries, females and the elderly reported more symptoms than males and the young; in Spanish and Italian samples, the pattern of differences is considerably more complex. Future research should thoroughly examine different age and gender groups. The analysis of emotional well-being in groups at risk of mental health issues may help to lessen the long term social and economic costs due to the COVID-19 outbreak.
Mental Health in Family Businesses and Business Families: A Systematic Review
Authors: Arijs Diane , Michiels Anneleen
Published: March 2021

Mental health issues in family businesses and business families have been studied in multiple disciplines within the past three decades. This article systematically reviews 51 articles on mental health issues in family businesses and business families, published in a wide variety of psychology, entrepreneurship, and management journals. Based on a systematic review of extant literature, this article first provides an overview of the state of the art, followed by specific suggestions on novel research questions, theoretical frameworks and study design. This way, the review systematizes evidence on known antecedents and consequences of mental health issues in family businesses and business families, but also reveals overlooked and undertheorized drivers and outcomes. The review reveals major gaps in our knowledge that hinder a valid understanding of mental health in the specific context of family businesses and business families, and articulates specific research questions that could be tackled by future research among management as well as mental health scholars. Finally, we point to the relevance of this study for policy makers, family business advisors, therapists and managers.
Six-Minute Walk Distance in Breast Cancer Survivors—A Systematic Review with Meta-Analysis
Authors: But-Hadzic Jasna , Dervisevic Mirza , Karpljuk Damir , Videmsek Mateja , Dervisevic Edvin , Paravlic Armin , Hadzic Vedran , Tomazin Katja
Published: March 2021

The six-minute walk test (6MWT) is a widely used test for the indirect measurement of cardiorespiratory fitness in various cancer populations. Although the 6MWT is a simple test, there are no normative values for breast cancer survivors (BCS) or comparisons of results with healthy counterparts. A systematic review with a meta-analysis was carried out, which included studies from 2007 to 2020. Ninety-one studies were found, 21 of which were included in the quantitative synthesis. Among them were 9 randomized controlled trials (RCT), 8 prospective cohort studies and 4 cross-sectional studies. A total of 1084 BCS were included. Our results revealed that healthy subjects (n = 878) covered a significantly greater distance than BCS during the 6MWT (589.9 m vs. 477.4 m, p < 0.001), and the results of the meta-regression analysis showed that the 6MWD was predicted by the participants’ BMI (p < 0.001), but not by their age (p = 0.070). After adjustment for BMI, the healthy subjects also covered greater distances than the BCS (103 m; p < 0.001). The normative values of 6MWT were presented for BCS. Besides, 6MWT distances distinguish between their healthy counterparts, therefore, the 6MWT distance is a relevant parameter for the assessment and monitoring of cardiorespiratory fitness in medical and exercise interventions for BCS.
A Relational Approach to the Design for Peer Support
Authors: Pahk Yoonyee , Baek Joon Sang
Published: March 2021

Peer-support services enhance mental wellbeing and increase the knowledge and capabilities of self-help groups in various settings. To ensure that these services foster peer-support relationships as intended, it is necessary to design and assess them from a relational perspective. This study presents a relational framework for peer-support design and its application to two existing peer-support services for solitary seniors in Seoul and Ulsan. The framework aims to support the analysis and conception of peer-support services. It incorporates network analysis and codesigning to understand multi-faceted peer-support relationships and to develop strategies for creating relational values, respectively. Case studies used observation and interviews to understand the multi-faceted issue of social support. Relational data for fourteen solitary seniors were collected and analyzed in terms of the qualities, quantities, and structure of peer-support relationships. Analysis results demonstrate an increased level of perceived peer support through relationship forming, as well as the factors that suppress peer-support building such as network fragmentation and the discrepancy of needs. Analysis results were fed into codesigning interventions with stakeholders. Based on these findings, we discuss the preconditions for building peer-support relationships and outline the relational approach to the design for peer support in a wider context.
Neuroeducation, Motivation, and Physical Activity in Students of Physical Education
Authors: Baena-Extremera Antonio , Ruiz-Montero Pedro Jesús , Hortigüela-Alcalá David
Published: March 2021

In recent years, neuroscience and neurodidactics have demonstrated significant progress in improving the teaching and learning process for various subjects, such as physical education [...]
Performance Parameters in Competitive Alpine Skiing Disciplines of Slalom, Giant Slalom and Super-Giant Slalom
Authors: B. Alejo Lidia , Gil-Cabrera Jaime , Montalvo-Pérez Almudena , Barranco-Gil David , Hortal-Fondón Jaime , Navandar Archit
Published: March 2021

The objective of this study was to describe the kinematic patterns and impacts in male and female skiers in the super-giant slalom, giant slalom and slalom disciplines of an international alpine skiing competition using a portable Global Navigation Satellite Systems (GNSS) technology device. Fifteen skiers (males, n = 9, females, n = 6) volunteered to participate in this study. Data acquisition was carried out using a wireless inertial measurement device (WIMUTM PRO: hybrid location system GNSS at 18 Hz with a precision locator UltraWideband UWD (<10 cm) and 3D accelerometers 1000 Hz) where distances covered in different speed and acceleration thresholds and impacts above 5g were recorded in each of the disciplines. Male and female alpine skiers showed different physical parameters and impacts even though they competed in the same courses in the disciplines of slalom, giant slalom and super-giant slalom (total impacts: p < 0.001; impacts > 7 g: p = 0.013; impacts 6.1–7 g: p = 0.002; impacts 5.1–6 g: p = 0.006). In male skiers, the distances traveled at different speed thresholds have a direct relation to the ranking of skiers, but this ideal threshold decreased as the technicality of the discipline increased. In the case of female skiers, although no relation was seen with the speed thresholds, greater distances covered at medium accelerations improved skiing performance. The external load in alpine skiing varied based on sex and discipline. This information could be essential to develop sex-specific and discipline-specific training programs in alpine skiing.
The Moderating Role of Pro-Innovative Leadership and Gender as an Enabler for Future Drone Transports in Healthcare Systems
Authors: Comtet Hans E. , Johannessen Karl-Arne
Published: March 2021

Drones have been suggested as an emerging technology that has the potential to disrupt and improve healthcare. The attitude among healthcare workers towards the use of drones is important for its successful implementation. Our aim was to examine individual and institutional variables among employees that may be relevant for the successful implementation of drones. This study used a self-administered questionnaire to investigate the expectations and beliefs among 400 employees at three Norwegian healthcare organizations regarding the future role of drones in the provision of healthcare. The results showed that the use of drones in healthcare is positively perceived across professional groups, age, and location. Working in an innovative environment, having experienced previous technological change in one’s working environment, and having leadership that supports new ideas were identified as drivers of individual beliefs regarding the use of drones as an innovative solution in future healthcare services. Men had significantly higher scores than women, and this was associated with reporting innovative leadership. This may indicate that a future implementation of drone usage should focus on local system environments and may depend on the presence of innovative leadership. Our results are harvested from a developed health care system and should be applicable for similar technologically advanced systems where the full potential of drone solutions may benefit from the integration of drones into the overall socio-technical system.
Geospatial Queries on Data Collection Using a Common Provenance Model
Authors: Closa Guillem , Masó Joan , Julià Núria , Pons Xavier
Published: March 2021

Lineage information is the part of the metadata that describes “what”, “when”, “who”, “how”, and “where” geospatial data were generated. If it is well-presented and queryable, lineage becomes very useful information for inferring data quality, tracing error sources and increasing trust in geospatial information. In addition, if the lineage of a collection of datasets can be related and presented together, datasets, process chains, and methodologies can be compared. This paper proposes extending process step lineage descriptions into four explicit levels of abstraction (process run, tool, algorithm and functionality). Including functionalities and algorithm descriptions as a part of lineage provides high-level information that is independent from the details of the software used. Therefore, it is possible to transform lineage metadata that is initially documenting specific processing steps into a reusable workflow that describes a set of operations as a processing chain. This paper presents a system that provides lineage information as a service in a distributed environment. The system is complemented by an integrated provenance web application that is capable of visualizing and querying a provenance graph that is composed by the lineage of a collection of datasets. The International Organization for Standardization (ISO) 19115 standards family with World Wide Web Consortium (W3C) provenance initiative (W3C PROV) were combined in order to integrate provenance of a collection of datasets. To represent lineage elements, the ISO 19115-2 lineage class names were chosen, because they express the names of the geospatial objects that are involved more precisely. The relationship naming conventions of W3C PROV are used to represent relationships among these elements. The elements and relationships are presented in a queryable graph.
Deciphering the Transcriptomic Heterogeneity of Duodenal Coeliac Disease Biopsies
Authors: Wolf Johannes , Willscher Edith , Loeffler-Wirth Henry , Schmidt Maria , Flemming Gunter , Zurek Marlen , Uhlig Holm H. , Händel Norman , Binder Hans
Published: March 2021

Coeliac disease (CD) is a clinically heterogeneous autoimmune disease with variable presentation and progression triggered by gluten intake. Molecular or genetic factors contribute to disease heterogeneity, but the reasons for different outcomes are poorly understood. Transcriptome studies of tissue biopsies from CD patients are scarce. Here, we present a high-resolution analysis of the transcriptomes extracted from duodenal biopsies of 24 children and adolescents with active CD and 21 individuals without CD but with intestinal afflictions as controls. The transcriptomes of CD patients divide into three groups—a mixed group presenting the control cases, and CD-low and CD-high groups referring to lower and higher levels of CD severity. Persistence of symptoms was weakly associated with subgroup, but the highest marsh stages were present in subgroup CD-high, together with the highest cell cycle rates as an indicator of virtually complete villous atrophy. Considerable variation in inflammation-level between subgroups was further deciphered into immune cell types using cell type de-convolution. Self-organizing maps portrayal was applied to provide high-resolution landscapes of the CD-transcriptome. We find asymmetric patterns of miRNA and long non-coding RNA and discuss the effect of epigenetic regulation. Expression of genes involved in interferon gamma signaling represent suitable markers to distinguish CD from non-CD cases. Multiple pathways overlay in CD biopsies in different ways, giving rise to heterogeneous transcriptional patterns, which potentially provide information about etiology and the course of the disease.
Local Administration of Low-Dose Nerve Growth Factor Antibody Reduced Pain in a Rat Osteoarthritis Model
Authors: Tian Yuan , Onodera Tomohiro , Terkawi Mohamad Alaa , Iwasaki Koji , Hishimura Ryosuke , Liang Dawei , Miyazaki Takuji , Iwasaki Norimasa
Published: March 2021

Systemic injection of a nerve growth factor (NGF) antibody has been proven to have a significant relevance in relieving osteoarthritis (OA) pain, while its adverse effects remain a safety concern for patients. A local low-dose injection is thought to minimize adverse effects. In this study, OA was induced in an 8-week-old male Sprague–Dawley (SD) rat joint by monoiodoacetate (MIA) injection for 2 weeks, and the effect of weekly injections of low-dose (1, 10, and 100 µg) NGF antibody or saline (control) was evaluated. Behavioral tests were performed, and at the end of week 6, all rats were sacrificed and their knee joints were collected for macroscopic and histological evaluations. Results showed that 100 µg NGF antibody injection relieved pain in OA rats, as evidenced from improved weight-bearing performance but not allodynia. In contrast, no significant differences were observed in macroscopic and histological scores between rats from different groups, demonstrating that intra-articular treatment does not worsen OA progression. These results suggest that local administration yielded a low effective NGF antibody dose that may serve as an alternative approach to systemic injection for the treatment of patients with OA.
Novel Transcriptome Study and Detection of Metabolic Variations in UV-B-Treated Date Palm (Phoenix dactylifera cv. Khalas)
Authors: Maher Mohamed , Ahmad Hasan , Nishawy Elsayed , Li Yufei , Luo Jie
Published: March 2021

Date palm (Phoenix dactylifera) is one of the most widespread fruit crop species and can tolerate drastic environmental conditions that may not be suitable for other fruit species. Excess UV-B stress is one of the greatest concerns for date palm trees and can cause genotoxic effects. Date palm responds to UV-B irradiation through increased DEG expression levels and elaborates upon regulatory metabolic mechanisms that assist the plants in adjusting to this exertion. Sixty-day-old Khalas date palm seedlings (first true-leaf stage) were treated with UV-B (wavelength, 253.7 nm; intensity, 75 μW cm−2 for 72 h (16 h of UV light and 8 h of darkness). Transcriptome analysis revealed 10,249 and 12,426 genes whose expressions were upregulated and downregulated, respectively, compared to the genes in the control. Furthermore, the differentially expressed genes included transcription factor-encoding genes and chloroplast- and photosystem-related genes. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to detect metabolite variations. Fifty metabolites, including amino acids and flavonoids, showed changes in levels after UV-B excess. Amino acid metabolism was changed by UV-B irradiation, and some amino acids interacted with precursors of different pathways that were used to synthesize secondary metabolites, i.e., flavonoids and phenylpropanoids. The metabolite content response to UV-B irradiation according to hierarchical clustering analysis showed changes in amino acids and flavonoids compared with those of the control. Amino acids might increase the function of scavengers of reactive oxygen species by synthesizing flavonoids that increase in response to UV-B treatment. This study enriches the annotated date palm unigene sequences and enhances the understanding of the mechanisms underlying UV-B stress through genetic manipulation. Moreover, this study provides a sequence resource for genetic, genomic and metabolic studies of date palm.
Confounding Roles of ER Stress and the Unfolded Protein Response in Skeletal Muscle Atrophy
Authors: Gallot Yann S. , Bohnert Kyle R.
Published: March 2021

Skeletal muscle is an essential organ, responsible for many physiological functions such as breathing, locomotion, postural maintenance, thermoregulation, and metabolism. Interestingly, skeletal muscle is a highly plastic tissue, capable of adapting to anabolic and catabolic stimuli. Skeletal muscle contains a specialized smooth endoplasmic reticulum (ER), known as the sarcoplasmic reticulum, composed of an extensive network of tubules. In addition to the role of folding and trafficking proteins within the cell, this specialized organelle is responsible for the regulated release of calcium ions (Ca2+) into the cytoplasm to trigger a muscle contraction. Under various stimuli, such as exercise, hypoxia, imbalances in calcium levels, ER homeostasis is disturbed and the amount of misfolded and/or unfolded proteins accumulates in the ER. This accumulation of misfolded/unfolded protein causes ER stress and leads to the activation of the unfolded protein response (UPR). Interestingly, the role of the UPR in skeletal muscle has only just begun to be elucidated. Accumulating evidence suggests that ER stress and UPR markers are drastically induced in various catabolic stimuli including cachexia, denervation, nutrient deprivation, aging, and disease. Evidence indicates some of these molecules appear to be aiding the skeletal muscle in regaining homeostasis whereas others demonstrate the ability to drive the atrophy. Continued investigations into the individual molecules of this complex pathway are necessary to fully understand the mechanisms.
Potato NAC Transcription Factor StNAC053 Enhances Salt and Drought Tolerance in Transgenic Arabidopsis
Authors: Wang Qi , Guo Cun , Li Zhiyuan , Sun Jinhao , Deng Zhichao , Wen Lichao , Li Xiaoxu , Guo Yongfeng
Published: March 2021

The NAC (NAM, ATAF1/2, and CUC2) transcription factors comprise one of the largest transcription factor families in plants and play important roles in stress responses. However, little is known about the functions of potato NAC family members. Here we report the cloning of a potato NAC transcription factor gene StNAC053, which was significantly upregulated after salt, drought, and abscisic acid treatments. Furthermore, the StNAC053-GFP fusion protein was found to be located in the nucleus and had a C-terminal transactivation domain, implying that StNAC053 may function as a transcriptional activator in potato. Notably, Arabidopsis plants overexpressing StNAC053 displayed lower seed germination rates compared to wild-type under exogenous ABA treatment. In addition, the StNAC053 overexpression Arabidopsis lines displayed significantly increased tolerance to salt and drought stress treatments. Moreover, the StNAC053-OE lines were found to have higher activities of superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD) under multiple stress treatments. Interestingly, the expression levels of several stress-related genes including COR15A,DREB1A, ERD11, RAB18, ERF5, and KAT2, were significantly upregulated in these StNAC053-overexpressing lines. Taken together, overexpression of the stress-inducible StNAC053 gene could enhance the tolerances to both salt and drought stress treatments in Arabidopsis, likely by upregulating stress-related genes.