bluuebunny/crossref_metadata_2025 huggingface dataset:
Inter-reader agreement of LI-RADS treatment response algorithm among three readers with different seniorities for hepatocellular carcinoma after locoregional therapy
Authors: Wang Yuxin , Asayo Himeko , Wang Wei , Xu Hui , Yang Dawei , Xu Lixue , Yang Siwei , Yang Zhenghan
Published: November 2024

Background

The accurate evaluation of tumor response after locoregional therapy is crucial for adjusting therapeutic strategy and guiding individualized follow-up.

Purpose

To determine the inter-reader agreement of the LR-TR algorithm for hepatocellular carcinoma treated with locoregional therapy among radiologists with different seniority.

Material and Methods

A total of 275 treated observations on 249 MRI scans from 99 patients were retrospectively collected. Three readers of different seniorities (senior, intermediate, and junior with 10, 6, and 2 years of experience in hepatic imaging, respectively) analyzed the presence or absence of features (arterial-phase hyperenhancement and washout) and evaluated LR-TR category.

Results

There were substantial inter-reader agreements for overall LR-TR categorization (kappa = 0.704), LR-TR viable (kappa = 0.715), and LR-TR non-viable (kappa = 0.737), but fair inter-reader agreement for LR-TR equivocal (kappa = 0.231) among three readers. The inter-reader agreement was substantial for arterial-phase hyperenhancement (kappa = 0.725), but moderate for washout (kappa = 0.443) among three readers. The inter-reader agreements between two readers were substantial for overall LR-TR categorization (kappa = 0.734, 0.727, 0.652), LR-TR viable (kappa = 0.719, 0.752, 0.678), and LR-TR non-viable (kappa = 0.758, 0.760, 0.694), which were at the same level as the inter-reader agreements among three readers. In addition, the inter-reader agreements between two readers were substantial for arterial-phase hyperenhancement (kappa = 0.733, 0.766, 0.678), but moderate for washout (kappa = 0.473, 0.422, 0.446), which were at the same level as the inter-reader agreements among three readers.

Conclusion

LR-TR algorithm demonstrated overall substantial inter-reader agreement among radiologists with different seniority.
Abnormal electromyographical trigeminal activation through stimulation of the offending artery (Z-L response): An intraoperative tool during microvascular decompression for trigeminal neuralgia
Authors: Montano Nicola , D’Alessandris Quintino Giorgio , Grilli Fulvio , Di Domenico Michele , Martinelli Renata , Burattini Benedetta , Izzo Alessandro , D’Ercole Manuela , Olivi Alessandro
Published: November 2024

Background

There are currently no intraoperative neurophysiological tools to assess the effectiveness of trigeminal nerve decompression during microvascular decompression surgery for drug-resistant trigeminal neuralgia. In microvascular decompression surgery for hemifacial spasm, an abnormal electromyographic activation of facial muscles after stimulation of the offending vessel was identified and named ‘Z-L response’.

Methods

We adapted a neurophysiological protocol to elicit a Z-L response during microvascular decompression surgery for trigeminal neuralgia and applied it to a prospective series of 18 surgical patients.

Results

Patients had suffered from trigeminal neuralgia for a median 9-year timeframe, and median preoperative Barrow Neurological Institute pain score was 4.5. Through monopolar stimulation, using rising amplitudes starting from 0.1 mA, we confirmed intraoperatively the true culprit vessel before decompression. In 4/18 cases, multiple offending vessels were identified (22 conflicts overall). After decompression, a significant increase in activation threshold (p < 0.0001) confirmed the effectiveness of the maneuver; in 10 cases, Z-L response was abolished. Using this technique, we obtained excellent or good outcome (Barrow Neurological Institute 1–3) in all patients, with a significant reduction in postoperative Barrow Neurological Institute score as compared with preoperative one (median Barrow Neurological Institute 1; p = 0.0002).

Conclusion

we provide the first evidence on the applicability and clinical usefulness of Z-L response during microvascular decompression surgery for trigeminal neuralgia.
Preserving contemporary newspapers: A new survey of state libraries in the USA
Authors: Pleiss David C
Published: November 2024

Newspaper collections require the use of archival science techniques and public librarianship. Indexing and public access are necessary for the provision of newspapers, while preservation underpins these efforts. In the United States, newspaper publishing tactics are changing quickly, causing upheaval in reading rooms and archival stacks. At the same time, the users’ focus upon digital access to newspapers has been wrongly conflated with the preservation formatting required to save them. A new U.S. survey of state library directors and newspaper collection managers addresses ways in which archivists and librarians evolve so that current titles with intrinsic value can be dovetailed into existing newspaper collections. Traditional practices of filming, digital image collecting, and print rotation still prevail. The survey was completed in 2023, and it is hoped that the findings will stimulate new discussions about newspaper preservation in the 21st century.
Effects of Losartan and Fisetin on Microfracture-Mediated Cartilage Repair of Ankle Cartilage in a Rabbit Model
Authors: Stake Ingrid K. , Gao Xueqin , Huard Matthieu , Fukase Naomasa , Ruzbarsky Joseph J. , Ravuri Sudheer , Layne Jonathan E. , Philippon Marc J. , Clanton Thomas O. , Huard Johnny
Published: November 2024

Background:

Microfracture is one surgical treatment strategy for osteochondral lesions of the talus (OLTs) but results in fibrocartilage repair tissue, which has inferior mechanical properties to native hyaline cartilage. Biological regulation of microfracture has been suggested to improve the quality of cartilage repair in patients.

Purpose:

To determine if administration of losartan, fisetin, or losartan and fisetin combined can enhance microfracture-mediated cartilage repair of OLTs in a rabbit model.

Study Design:

Controlled laboratory study.

Methods:

Four-month-old female rabbits were divided into the following groups (8 rabbits per group): microfracture only (microfracture), microfracture plus losartan (losartan), microfracture plus fisetin (fisetin), and microfracture plus losartan and fisetin (losartan+fisetin). A 2.7-mm osteochondral defect and 4 microfracture holes were created in the talar dome cartilage. The rabbits were administered losartan (10 mg/kg/day), fisetin (20 mg/kg/day), or losartan and fisetin orally until euthanized 12 weeks after surgery. Gross evaluation, micro–computed tomography, histology, and immunohistochemistry evaluations of the osteochondral defects were performed as well as quantitative polymerase chain reaction of capsule tissue and enzyme-linked immunosorbent assay of serum.

Results:

The losartan and fisetin groups had increased International Cartilage Regeneration & Joint Preservation Society macroscopic scores with improved cartilage repair and enhanced subchondral bone healing compared with the microfracture group. However, the losartan+fisetin group did not show a synergistic effect. O’Driscoll histology scores were higher in the losartan and fisetin groups compared with the microfracture group, while the losartan+fisetin group had a lower score than the losartan, fisetin, and microfracture groups. Collagen type 2 staining revealed organized chondrocytes in the losartan and fisetin groups, but the losartan+fisetin group did not show improvement when compared with other groups. Fisetin treatment decreased catalase and transforming growth factor-β1–activated kinase 1 expression in capsular tissue.

Conclusion:

Concomitant microfracture and biological regulation, using oral administration of either losartan or fisetin, may improve cartilage healing of OLTs; however, losartan and fisetin combined in the current drug administration regimen does not appear to provide synergistic effects.

Clinical Relevance:

Oral intake of losartan or fisetin may result in beneficial effects on microfracture-mediated cartilage repair of OLTs.
Predicting the Reparability of Rotator Cuff Tears: Machine Learning and Comparison With Previous Scoring Systems
Authors: Do Woo-Sung , Shin Seung-Hwan , Lim Joon-Ryul , Yoon Tae-Hwan , Chun Yong-Min
Published: November 2024

Background:

Repair of rotator cuff tear is not always feasible, depending on the severity. Although several studies have investigated factors related to reparability and various methods to predict it, inconsistent scoring methods and a lack of validation have hindered the utility of these methods.

Purpose:

To develop machine learning models to predict the reparability of rotator cuff tears, compare them with previous scoring systems, and provide an accessible online model.

Study Design:

Cohort study; Level of evidence, 3.

Methods:

Arthroscopic rotator cuff repairs for tears with both anteroposterior and mediolateral diameters >1 cm on preoperative magnetic resonance imaging were included and divided into a training set (70%) and an internal validation set (30%). For external validation, rotator cuff repairs performed by 2 different surgeons were included in a test set. Machine learning models and a newly adjusted scoring system were developed using the training set. The performance of the models including the adjusted scoring system and 2 previous scoring systems were compared using the test set. The performance was assessed using metrics such as the area under the receiver operating characteristic curve (AUROC) and compared using the net reclassification improvement based on the adjusted scoring system.

Results:

A total of 429 patients were included for the training and internal validation set, and 112 patients were included for the test set. An elastic-net logistic regression demonstrated the best performance, with an AUROC of 0.847 and net reclassification improvement of 0.071, compared with the adjusted scoring system in the test set. The AUROC of the adjusted scoring system was 0.786, and the AUROCs of the previous scoring systems were 0.757 and 0.687. The elastic-net logistic regression was transformed into an accessible online model.

Conclusion:

The performance of the machine learning model, which provides a probability estimation for rotator cuff reparability, is comparable with that of the adjusted scoring system. Nevertheless, when deploying prediction models beyond the original cohort, regardless of whether they rely on machine learning or scoring systems, clinicians should exercise caution and not rely solely on the output of the model.
Describing the Relationship Between Word Decoding, Oral Language, Phonemic Awareness, and the Orthographic Lexicon in the KTEA-3 and WIAT-4
Authors: Parkin Jason R. , Hajovsky Daniel B. , Alfonso Vincent C.
Published: November 2024

Practitioners are encouraged to apply theories of reading development to psychoeducational test interpretation. Orthographic mapping provides an explanation of the acquisition of sight words. Although many test batteries provide tasks for practitioners to assess reading components associated with orthographic mapping, the relationship among components will vary across batteries and specific task demands that can impact their interpretation by practitioners. This study evaluated the effects of phonemic awareness and oral language skills on various indicators of orthographic mapping competence while controlling for word decoding skills in the standardization samples of the Kaufman Tests of Educational Achievement, 3rd Edition (KTEA-3) and the Wechsler Individual Achievement Test, Fourth Edition (WIAT-4). The WIAT-4 phonemic awareness subtest’s task demands and relationships between it and some measures of word reading conform to the phonemic proficiency hypothesis. We discuss implications for comprehensive psychoeducational assessment when evaluating student reading development.
Spectres of critique: The nostalgia of social transformation
Authors: Boland Tom , Stypinska Diana
Published: November 2024

A century on from the foundation of the Frankfurt School with its slow institutionalisation of Critical Theory, almost every perspective in academia, activism and beyond is more or less implicitly critical and promises transformation. Traditional bastions of critique, socialism, feminism, post-colonialism have not only diversified to address a plethora of issues, but have been imitated by counter-critiques on the right, the back-lash and so forth. Beyond explicitly politicised variants, neo-liberalism, governmentality and rationalistic science all demonstrate a critical animus. The suffusion of pop culture, consumerism and everyday life with critique is also evident. All this critique promises social transformation partially by declaring the success of past emancipation, revolution, and even incomplete triumphs. In short, we are haunted by the spectre of critique past, yearning for the possibilities of future critiques, but meanwhile stuck in the contemporary predicament of omnipresent critique. Facing existential ecological crises, critique becomes nostalgic for social transformations, hoping to reiterate the critiques of the past, to deliver on the always as yet unfulfilled promises. Perhaps today, the spectre of critique and the promise of social transformation must be refused and rethought, to make radical political change possible.
Gender and healthcare leadership: Addressing critical knowledge gaps by explicitly considering the gendered concept of care
Authors: James Yvonne , Hermosura Billie Jane , Decady Ruth , Bourgeault Ivy L.
Published: November 2024

This scoping review of gender and healthcare leadership synthesized the barriers and facilitators at multiple levels employing a framework that integrates a specific focus on the concept of care. The 71 sources identified focus predominantly on barriers to women’s leadership at the individual and team level and, to a lesser extent, at the organizational and system level. Facilitators tend to be presented as recommended actions than evaluated interventions. Healthcare leadership tends to ignore the gendered context of care elevating leaders who are least likely to provide such care. Where personal caregiving circumstances are considered, they are individualized, reflecting the literature in general. More critical analysis is needed to focus on women’s experiences and how their gender can predetermine their success in achieving and being in leadership positions. Healthcare leadership researchers are encouraged to include gender and care-focused analyses and interventions to address the under-representation of women in healthcare leadership.
Adult Code Sepsis: A Narrative Review of its Implementation and Impact
Authors: Giglio Andrés , Aranda María , Ferre Andres , Borges Marcio
Published: November 2024

This narrative review explores the implementation and impact of sepsis code protocols, an urgent intervention strategy designed to improve clinical outcomes in patients with sepsis. We examined the degree of implementation, activation criteria, areas of implementation, personnel involved, responses after activation, goals and targets, impact on clinical indicators, and challenges in implementation. The reviewed evidence suggests that sepsis codes can significantly reduce sepsis-related mortality and enhance early administration of treatments. However, variability in activation criteria and inconsistent application present ongoing challenges. The review considers the incorporation of newer scoring systems, such as NEWS and MEWS, and the potential integration of machine learning tools for early sepsis detection. It highlights the importance of tailoring implementation to specific healthcare contexts and the value of ongoing training to optimize sepsis response. Limitations include the ongoing controversy surrounding sepsis definitions and the need for standardized, feasible quality indicators. Future research should focus on standardizing activation criteria, improving protocol adherence, and exploring emerging technologies to enhance early sepsis detection and management. Despite challenges, sepsis codes show promise in improving patient outcomes when implemented thoughtfully and consistently across healthcare settings.
Evaluation of the Rostral Inferior Alveolar Nerve Block via the Mental Foramen in Equids: In Vivo Efficacy Testing
Authors: Broman Ashton , Rawlinson Jennifer E. , Bass Luke , Boscan Pedro , Rao Sangeeta
Published: November 2024

The use of proper sedative and regional anesthetic protocols is essential when performing equine dental surgical procedures under standing sedation. The efficacy of the rostral inferior alveolar nerve block via the mental foramen has not been previously studied. Aims of this study included determining the efficacy of the block, investigating whether any region (labial mucosa, alveolar mucosa, or teeth) was more reliably anesthetized, and if differences in efficacy existed between bilateral and unilateral blocks. In this blinded trial, 10 horses each were randomly assigned to receive a left unilateral block, right unilateral block or bilateral blocks and 5 horses were bilateral controls. For unilateral groups, the contralateral side of the horse acted as its own unilateral control. Mechanical nociceptive stimulus methods were used to determine response to stimulus at time points pre-sedation, post-sedation, and post-injection at 10, 30, 60, and 90 min. Results were evaluated in 4 groups: unilateral blocks, unilateral controls, bilateral blocks and bilateral controls. Overall, all groups were significantly less likely to respond to stimulus at time points post-sedation, T10, and T30, whereas only blocked sites were less likely to respond at T60 and T90 compared to pre-sedation. There was no significant difference in response to stimuli of blocked sites between the 3 regions at all time points. Overall, at T60 and T90, blocks produced regional anesthesia in 73% and 55% of sites, respectively. This study demonstrated the equine mental foramen regional nerve block has varied efficacy, producing partial or incomplete regional anesthesia in some cases.
Microstructural, mechanical, and wear properties of ultrasonic assisted stir casted A356 Alloy/AlN composite
Authors: Kumar T Satish , Kumar K Krishna , Bhowmik Abhijit , Bhattacharjee Biplab , Katiyar Jitendra Kumar
Published: November 2024

The ultrasonic-assisted stir-casting method has effectively prepared A356 alloy/AlN composites. The ultrasonic treatment and integration of AlN particles are shown to greatly enhance the mechanical and wear characteristics of the matrix via grain refinement. By incorporating 9 vol.% of AlN reinforced particles, the average grain size of A356 alloy was decreased from 36 μm to 10 μm. Additionally, the hardness and tensile strength experienced a respective rise of 60.6% and 32%. With an increase in the volume percentage of AlN particles, it is found that both the wear rate and the friction coefficient decreased. It is also observed that the A356 alloy displayed severe wear, whereas the composites exhibited moderate wear.
The Complexity of Funding International Research Collaboration. An Analysis of Partnership and Rivalry Between the EU and China
Authors: Marini Giulio , Mouritzen Mikkel
Published: November 2024

In recent years, increased rivalry between China and the EU has been seen as a threat to cooperation, including in the field of higher education and scientific research. We explore how cooperation in research between China and the EU has developed over time via a bibliometric analysis of international co-authorships within four different funding agencies (CAS, MOST, JRC, and ESA). Our findings suggest that EU-China cooperation has continued to strengthen, despite a new options for “rivalry to increase between these two parties”. We suggest that this is explained by the benefits that both the EU and China receive from collaboration, albeit such benefits differ in type. Possibly, our findings are also a byproduct of adjustments triggered initially by the US “China Initiative”. The dilemma of whether to collaborate or not is likely to become more pressing, as the policies of some funding agencies have implications for national defense and security.
Facilitated Advance Care Planning Interventions: A Narrative Review
Authors: Penumarthy Akhila , Zupanc Seth N. , Paasche-Orlow Michael K. , Volandes Angelo , Lakin Joshua R.
Published: November 2024

Introduction: Multiple interventions have been designed to employ facilitators to address gaps in Advance Care Planning (ACP). Objective: To collect and review available evidence related to facilitated ACP interventions. Methods/Design: Narrative review using a previously described framework for scoping reviews. We searched PubMed using structured criteria and report synthesized themes detailing the design, target populations, methods, and outcome measurements for interventions in which a facilitator—who may or may not be clinical staff—engaged a patient and/or a patient’s caregiver in some part of the ACP process. Results: Of 1492 articles discovered on our search, 28 met the inclusion criteria. Twelve (42.9%) studies utilized a nurse facilitator, two (7.1%) utilized trained social workers, and one (3.6%) embedded multiple facilitators. The remaining 13 (46.4%) utilized facilitators from other various professional and community backgrounds, such as lay navigators, care coordinators, and peer mentors. Twenty-five (89.2%) studies included patients with serious or chronic illness, at the end-of-life, or having a high risk of need for medical care. Four (14.3%) articles focused on marginalized populations. Intervention settings varied notably across studies. Eighteen (64.3%) integrated interventions into existing clinical workflows. Primary outcomes were measured in one of three ways: documentation in the Electronic Health Record (EHR) (25.0%); questionnaires, scales, patient reports, or non-EHR documentation (64.3%); or multiple measures (10.7%). Twenty-three (82.1%) of the studies were determined a success by study authors. Conclusion: We identified a variety of key characteristics that can be modified to target facilitated ACP interventions towards gaps in current applications of ACP.
Racial and Ethnic Identity of Transnational Adoptees: A Model Reflecting the Lived Experience of Adult Colombian Adoptees
Authors: Cloonan Veronica , Branco Susan
Published: November 2024

International and transracial adoptions have been practiced by multiple developed countries since World War II, where transracial adoptees are removed from their country of origin and raised by parents of a completely different cultural and racial background. In the United States, adoption was institutionalized after the Korean War, making adoption across races a common practice. This demographic change brings different developmental challenges to the transracial adoptee, including the task of racial and ethnic identity. In this dissertation study, the authors dived into the narratives of six Colombian transracial adoptees raised in the United States by White parents to understand their stories regarding their racial and ethnic identity process. The authors’ findings include the development of a racial and ethnic identity model that emerged from the participants’ themes and common lived experiences, including five nonlinear stages: questioning and curiosity; action-seeking behaviors; judgment and expectations; reculturation and reclaiming; and wanting to embrace both identities. Adult Colombian adoptees highlighted the fluidity of their racial and ethnic identity process and the importance of reclaiming and reconnecting with their Colombian part of self as part of this process. The ethnic and racial identity model informs mental health professionals’ clinical and professional practice by offering a guide to comprehending the process and some of the common experiences around ethnic and racial identity among transracial adoptees.
Sleep Management: The Use of Continuous Physiological Monitoring to Support Patient Self-Care
Authors: McCormack Cassandra M. , Caldwell Barrett S.
Published: November 2024

Circadian misalignment (CM) is a sleep disruption where an individual’s circadian rhythm and actual sleep-wake cycle are unsynchronized. CM is frequently misdiagnosed and difficult to treat but can adversely impact short-term and long-term health outcomes. CM often interacts bidirectionally with chronic conditions affecting cognitive and physical functionality. Continuous physiological monitoring (CPM) of the hormone melatonin would support real-time, patient-driven interventions to address CM. However, patient-driven self-care tasks involve complex information processing and decision-making. Effective CPM use requires situation awareness regarding current circadian health and projected future status, sufficient background knowledge to identify circadian intervention alternatives, and selection of appropriate alternatives given their current state. Melatonin data has characteristics distinct from biomarkers previously subject to CPM, introducing further challenges around data presentation. Task analysis efforts can identify the cognitive processes involved in five different tasks associated with a continuous melatonin monitor to identify necessary informational elements to include in interface design.
The ECP SICM project: Managing complex memory hierarchies for exascale applications
Authors: Bujack Roxana , Gokhale Maya , Ionkov Latchesar , Iwabuchi Keita , Jantz Michael , Jones Terry , Lakshmiranganatha Sumathi , Lang Michael K , Lee Jason , Olson M. Ben , Pakin Scott , Pearce Roger , Pietarila Graham Jonathan , Tang Li , Turton Terece L , Williams Sean
Published: November 2024

The Exascale Computing Project (ECP)’s Simplified Interface to Complex Memories (SICM) effort focuses on developing universal interfaces for discovering, managing, and sharing data across complex memory hierarchies. These facilitate the exploitation of emerging memory technologies and support precise control over their various trade-offs such as high-bandwidth versus low-latency, persistent versus ephemeral, high-capacity versus low-capacity, and near-CPU versus near-GPU. SICM comprises three interrelated components: a low-level interface, a high-level interface, and a persistent-heap interface. The low-level SICM interface is intended for system and run-time developers as well as expert application developers who prefer full control of the memory objects used within their application. The high-level SICM interface builds upon the low-level interface, employing application-level profiling and analysis to optimize data management for complex memory hierarchies. The persistent-heap interface provides applications with a persistent memory allocator that can allocate custom C++ data structures in both block-storage and byte-addressable persistent memories.
The Internet Never Forgets: A Four-Step Scraping Tutorial, Codebase, and Database for Longitudinal Organizational Website Data
Authors: Haans Richard F.J. , Mertens Marc J.
Published: November 2024

Websites represent a crucial avenue for organizations to reach customers, attract talent, and disseminate information to stakeholders. Despite their importance, strikingly little work in the domain of organization and management research has tapped into this source of longitudinal big data. In this paper, we highlight the unique nature and profound potential of longitudinal website data and present novel open-source code- and databases that make these data accessible. Specifically, our codebase offers a general-purpose setup, building on four central steps to scrape historical websites using the Wayback Machine. Our open-access CompuCrawl database was built using this four-step approach. It contains websites of North American firms in the Compustat database between 1996 and 2020—covering 11,277 firms with 86,303 firm/year observations and 1,617,675 webpages. We describe the coverage of our database and illustrate its use by applying word-embedding models to reveal the evolving meaning of the concept of “sustainability” over time. Finally, we outline several avenues for future research enabled by our step-by-step longitudinal web scraping approach and our CompuCrawl database.
Roles of DNMT3B and PARP1 Genes Expression in Cytogenetically Normal Acute Myeloid Leukemia
Authors: Mahmoud Hager A , Botros Shahira KA , Fouad Abdelhamid Mohamed , Kamel Mahmoud M , Abdel Aziz Rania S
Published: November 2024

Background:

Acute myeloid leukemia (AML) has a heterogeneous molecular profile, clinical presentations, and response to treatments and outcomes. DNA methylation is conducted by DNA methyltransferases including DNMT3B. Poly ADP-ribose polymerase 1 belongs to a family of enzymes that mediate important cellular processes including DNA repair, transcription, and cell death/cell proliferation, and it is involved in the development, spread, treatment, and prognosis of some cancers. The objective of this study is to assess the impact of PARP1 and DNMT3B genes expression on laboratory characteristics, response to treatment and survival in Egyptian cytogenetically normal AML patients.

Methods:

This study included 67 Egyptian CN-AML patients in addition to 8 healthy bone marrow donors. Measurement of DNMT3B and PARP1 gene expression was done on bone marrow samples via real-time semiquantitative polymerase chain reaction.

Result:

Expression of both DNMT3B and PARP1 genes was significantly upregulated in AML ( P = .001, P = .036, respectively). Upregulated DNMT3B was associated with higher total leukocyte count (TLC), PB, and BM blast cell%. Also, upregulated PARP1 correlated with higher TLC, PB, and BM blast cell%. High expression of both DNMT3B and PARP1 correlated with greater frequencies of FLT3-ITD. High DNMT3B expression, and combined upregulation of both PARP1 and DNMT3B genes associated significantly with ELN stratification. But no correlation was found with response (CR), overall survival (OS), disease-free survival (DFS), or event-free survival (EFS).

Conclusion:

Our findings highlight the importance of considering DNMT3B and PARP1 expression levels as potential prognostic biomarkers for progression and aggressiveness of CN-AML patients in AML. Assessing their expression levels could be an indicator to guide treatment decisions and potentially improve patient outcomes.
Social Media marketing and restaurants’ brand equity after COVID-19: A revitalizing model
Authors: Al-Abdallah Ghaith , Ismael Mariwan , Attieh Latifa
Published: November 2024

The COVID-19 pandemic has reshaped the establishment of long-term brand equity through social media marketing (SMM) due to the imperative of swiftly adapting to dynamic digital landscapes and heightened competition. This study investigates the impact of SMM on customer-based brand equity (CBBE) for restaurants in the post-COVID-19 era, by reevaluating the SMM model and postulating the effect of electronic word-of-mouth (e-WOM) as a mediating variable rather than an independent one. The study adopts a deductive approach and a descriptive methodologvisualisey where a quantitative survey-based strategy utilizing a five-point Likert scale questionnaire was employed. The validated questionnaire was distributed online to active social media users following local restaurant social media accounts; a convenience sample was utilized. After filtering and screening, 618 responses were analyzed using partial least squares (PLS)-SEM to test the proposed hypotheses. Our findings emphasize that interaction is the most influential factor in shaping restaurants’ CBBE, followed by trendiness and customization. In contrast, entertainment does not significantly affect CBBE. Additionally, e-WOM mediates the relationship between SMM and CBBE. Repositioning e-WOM in the model enhances our comprehension of its impact compared to its previous position, as it cannot be completely controlled by restaurants. In-depth discussions and managerial and theoretical implications are provided.
Study on micro-grinding mechanism and surface quality of hardened 20 vol% SiCp/Al composites
Authors: Zhao Bintong , Gao Qi , Zheng Baohong , Sun Hailong , Jia Dongzhou
Published: November 2024

Particle-reinforced aluminum-based silicon carbide composites (SiCp/Al) are widely used in aerospace, rail transit, and other fields due to their excellent comprehensive properties. However, the incorporation of high-brittle SiC particles poses challenges in the high-performance processing of SiCp/Al composites. This study focuses on hardened 20 vol% SiCp/Al composites, establishing two-dimensional finite element cutting models for single SiC particles. Micro-grinding experiments are conducted under various processing parameters. The influence law of surface defects on individual SiC particles relative to tool position and single factor machining parameters was analyzed, revealing the micro-grinding mechanisms affecting surface and subsurface quality. The results show that the interaction among particle damage mechanisms, crack propagation directions, and the restraining effects of the Al matrix leads to diverse types of defects at different cutting positions. Both simulation and experimental observations reveal surface defects such as pits, gullies, and burrs, while subsurface damage primarily results from crack invasion, cavity interstices, and pits due to particle breakage. The experiment achieved a minimum roughness of 0.057 μm. Taking into account the thermal softening of the material and the micro-behavior of the tool-chip interface, optimal conditions for improved surface quality involve a grinding depth of 0.03 mm, a spindle speed of 12,000 rpm, and a relatively low feed rate.
A proposal in plastic: Jane Austen in Barbie Land
Authors: Gillis Stacy
Published: November 2024

I read the references to the Regency Romance in Barbie (2023) as key moments in the film's challenge to heteronormative structures of romance and marriage. Diplomat Barbie (Nicola Coughlan) and the Depression Barbie advertisement set up the premise of the film in terms of women's voice, women's self-actualisation and – with its claiming of selfhood – a rejection of heteronormative structures of romance as being one of the primary modes of defining women's role and function. The film's fundamental joyful unwillingness to detach from the unserious – while at the same time foregrounding and then rejecting the heteronormative marriage plot that is indispensable for the Regency Romance – brings us back to the unserious and to laughter as a mode of resistance to capitalism and the patriarchy.
‘You can stay if you want, as my bride wife’: mapping Barbie Land onto Bachelor Nation
Authors: O’Hare Gráinne
Published: November 2024

I identify key tropes in the television franchise The Bachelor/ette (2002–), mapping the reality TV dating narrative onto Barbie Land and examining the ways in which Barbie (2023) parallels and/or subverts these constructs. Ryan Gosling's remarks that The Bachelorette informed his portrayal of Beach Ken provide a starting point for analysing the ways in which a lack of heteronormative temporality in Barbie Land renders the Barbies free from the burden of patriarchal domesticity. I also consider Stereotypical Barbie (Margot Robbie) as reflective of a traditional Bachelorette series lead, and the shortcomings of the TV franchise in terms of platforming people of colour and casting racially diverse leads in the series. I juxtapose these two texts to highlight the ways in which Barbie offers an antithetical microcosm that challenges the heteronormative reality TV dating format and conservative conceits perpetuated by the Bachelor/ette franchise.
Violence Against Women and Girls in Zimbabwe: A Review of a Decade of the Empirical Literature
Authors: Bengesai Annah V. , Chikhungu Lana
Published: November 2024

Violence against women and girls (VAWG) is a complex social problem affecting many women globally. In Zimbabwe, intimate partner violence (IPV) and child marriages remain persistent public health problems with detrimental effects on the health and well-being of women and girls. Statistics show that Zimbabwe has one of the highest rates of IPV and child marriage in sub-Saharan Africa. Given this background, this paper systematically reviewed published research on VAWG in Zimbabwe from 2012 to 2022 to identify research gaps. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, we systematically searched for literature across five electronic databases: Web of Science, Medline, Psych-Info via EBSCO-Host, and Google Scholar. Our initial search yielded 261 articles, of which only 45 met our inclusion criteria. We summarized these studies using thematic analysis and performed a quality assessment using the Mixed Methods Appraisal Tool. The findings revealed several gaps, including a limited focus on relational and perpetrator perspectives, insufficient attention to other forms of VAWG such as non-partner sexual violence, rape, and trafficking, and a lack of studies on marginalized groups such as people with disabilities, sex workers, and same-sex couples. In addition, there were no longitudinal studies examining trends and dynamics of VAWG over extended periods or comparing different geographical regions. Few studies also focused on the evaluation of interventions. Although significant progress has been made in addressing VAWG, this review underscores the need for more research to fill these gaps for effective and evidence-based policymaking and response strategies.
Research Driven Dialogs: A Method for Social and Scholarly Impact
Authors: Jakimow Tanya , Gomez Mario , Gunasekera Viyanga , Harahap Aida Fitri , Siahaan Asima Yanty , Vanniasinkam Nadine , Vijeyarasa Ramona , Yumasdaleni
Published: November 2024

Research Driven Dialogs (RDDs) are a method for collective sense-making and collaborative reflection on research findings by a range of stakeholders hoping to better understand and address a complex problem. Research findings are opened up through a process of dialog; implications for practice and action are co-designed by participants in ways that are compatible with institutional and sociocultural realities. RDDs thereby coproduce knowledge in ways that maximize social impact and deepen and contextualize scholarly insights without imposing excessive time-burdens on stakeholders. We present an overview of the stages of RDDs through a development leadership project in Sri Lanka and Indonesia, outlining how these can be designed to maximize research outcomes and extraneous benefits.
BOLDly Going Where Few Researchers Have Gone Before—Leveraging Language-Related Hippocampal Activations to Predict Postoperative Memory Decline
Authors: McDonald Carrie R.
Published: November 2024

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Educational leadership styles and practices perceived by academics: An exploratory study of selected Chinese universities
Authors: Cheng Zhao , Zhu Chang
Published: November 2024

Universities have faced enormous challenges in China, requiring educational leaders to meet the demands of change. The purpose of this study is to explore academic members’ descriptions of their personal educational leadership styles, leadership practices, the influence of organizational structure features on educational leadership practices, and to examine the effect of educational leadership practice on teaching and learning at selected Chinese universities. Through qualitative research design, we inquired about the views of 15 academic members from nine Chinese universities. A content analysis method by MAXQDA2022 is used in this study. The findings provide a comprehensive picture of educational leadership styles, practices, and the perceived effects of educational leadership practices on teaching and learning in the context of selected Chinese universities. The results can be helpful for educational leaders in optimizing educational leadership practices to improve teaching and learning at higher education institutions.
HIV-hypertension treatment outcomes among adults on antiretroviral therapy in two states in Northern and Southern Nigeria: a cross-sectional design approach
Authors: Ajayi Oluseye Ayodele , Babatunde Deborah , Ajayi Oluwaseun Kikelomo , Ojo Temitope Olumuyiwa , Okonkwo Prosper
Published: November 2024

Background:

The combined effect of the aging human immunodeficiency virus (HIV) population, HIV’s natural progression, and HIV drugs have great implications for comorbidity burden and hypertension control among people living with HIV (PLHIV).

Objectives:

This study assessed hypertension burden, treatment outcomes, and treatment outcome predictors among PLHIV in Nigeria.

Design:

Cross-sectional design.

Methods:

A cross-sectional study of 2613 adult PLHIV who initiated antiretroviral therapy (ART) between 2004 and 2020 in two HIV clinics in Northern and Southern Nigeria. Study outcomes were: (1) controlled blood pressure defined as two consecutive blood pressure (BP) measurements of <140/90 mmHg (Joint National Committee guideline (JNC) 7) on the interview day in previously diagnosed hypertensive participants; and (2) HIV viral suppression defined as recent viral load count of <1000 copies/ml in a hypertensive participant. Data were analyzed using Statistical Package of Social Sciences IBM version 23. Univariate and multivariate logistic regression was done to ascertain factors associated with the study outcomes at p < 0.05.

Result:

The mean age of respondents at the point of the study was 45.3 ± 9.8 years. Most of the participants were female, 1940 (74.2%), on a dolutegravir-based therapy, 2433 (93.2%). About 452 (17.3%) of the participants had clinically diagnosed hypertension. Of those diagnosed hypertensives, 443 (98.0%) were on antihypertensive drugs. About 407 (90.0%) and 229 (51.7%) of the hypertensive PLHIV had HIV viral suppression and controlled hypertension respectively. Factors associated with controlled hypertension were age at ART initiation (adjusted odds ratio (AOR): 0.96, 95% CI: 0.94–0.98), use of thiazide only antihypertensive (AOR: 1.91, 95% CI: 1.73–3.24, Ref: calcium channel blocker only) and thiazide-calcium channel blocker combination (AOR: 2.19, 95% CI: 1.05–4.58). No hypertension comorbidity-related factors were found to be associated with HIV viral suppression.

Conclusion:

There is suboptimal hypertension control among hypertensive PLHIV especially those on non-thiazide-based antihypertensive drugs. Close monitoring should be given to hypertension management in PLHIV.
Big data in breast cancer: Towards precision treatment
Authors: Zhang Hao , Hussin Hasmah , Hoh Chee-Choong , Cheong Shun-Hui , Lee Wei-Kang , Yahaya Badrul Hisham
Published: November 2024

Breast cancer is the most prevalent and deadliest cancer among women globally, representing a major threat to public health. In response, the World Health Organization has established the Global Breast Cancer Initiative framework to reduce breast cancer mortality through global collaboration. The integration of big data analytics (BDA) and precision medicine has transformed our understanding of breast cancer's biological traits and treatment responses. By harnessing large-scale datasets – encompassing genetic, clinical, and environmental data – BDA has enhanced strategies for breast cancer prevention, diagnosis, and treatment, driving the advancement of precision oncology and personalised care. Despite the increasing importance of big data in breast cancer research, comprehensive studies remain sparse, underscoring the need for more systematic investigation. This review evaluates the contributions of big data to breast cancer precision medicine while addressing the associated opportunities and challenges. Through the application of big data, we aim to deepen insights into breast cancer pathogenesis, optimise therapeutic approaches, improve patient outcomes, and ultimately contribute to better survival rates and quality of life. This review seeks to provide a foundation for future research in breast cancer prevention, treatment, and management.
‘Comrade or coloniser’: Competing discourses on Sino-Zimbabwe relations in the local press
Authors: Chari Tendai
Published: November 2024

Deploying Michel Foucault’s discourse theory, this article qualitativey explores Sino-Zimbabwe engagements in four Zimbabwe newspapers to shed insights into how these relations are interpreted in a context. How the newspapers discursively constructed Sino-Zimbabwe engagements, the rationale for such constructions, as well as the perceptions of journalists on these engagements are questions at the core of this exploration. The article revealed competing discourses between the state-owned and the privately owned newspapers in relation to China–Zimbabwe engagements. Among the journalists, the study found mixed views, ranging from optimism, scepticism, and pragmatism. Given the polarised media discourses on China–Zimbabwe engagements, and the centrality of the press in shaping public opinion, perceptions and attitudes, Zimbabwean government may face an uphill task in trying to convince their citizens that their relationship is mutually beneficial, while China may face a similar predicament in trying to reduce stereotypes in Africa.
Directors’ Joint Work on Corporate Fraud? The roles of Director Subgroup Interlocking Networks in China
Authors: Zhang Qirui , Wang Xiao , Zhong Lichen
Published: November 2024

Although prior research has explored the influence of board’s external connectedness on corporate fraud in the U.S., how such influence works in economies with concentrate ownership like China remain largely unexplored. The highly concentrated ownership in China not only exacerbates principal-principal conflicts but also lead to the formation of director subgroup within the board and the separation of board’s external social networks. To explore the impact of board’s social network on corporate fraud in such a unique context in China, it is important to adopt a subgroup-level network lens. Filling this gap, using a binary probit regression model with partial observability on 1,530 Chinese publicly listed companies with corporate violation announcements data from 2003 to 2013, this study analyzes the impact of two director subgroup interlocking networks on corporate fraud occurrence and fraud detection. The empirical results show that high centrality in the dependent director subgroup interlocking network contributes to fraud deterrence, and the high centrality in the independent director subgroup interlocking network facilitates both fraud deterrence and fraud detection. This study contributes to corporate governance research by exploring the influence of social networks on corporate fraud with a subgroup-level network lens in China. Meanwhile, the formulation of two parallel director subgroup interlocking networks introduces a novel analytical framework for future interlocking directorship research in scenarios where the board is subject to a structured division.
Patient Perspectives of Integrated Behavioral Health in Primary Care: A Mixed Methods Analysis
Authors: Gurfinkel Dennis , Owen Vanessa , Kreisel Carlee , Hosokawa Patrick , Kluger Samantha , Legge Courtney , Calderone Jacqueline , Eskew Alisha , Waugh Maryann , Shore Jay H , Brown Levey Shandra M , Holtrop Jodi Summers
Published: November 2024

Integrated and collaborative care models, in which mental/behavioral health providers work closely with primary care providers within a primary care setting, help support the quadruple aim of improved health outcomes, patient satisfaction, provider experience, and lower cost. In this paper, we describe patients’ general perspectives of integrated care and their unique experiences accessing this care within one health system. Qualitative (interviews with patients) and quantitative (surveys with patients) methods were used to collect and analyze these results separately and together. The results highlight important features to the provision of integrated care from the perspective of patients using integrated care. They include the importance and experience of access, whole-person care and a team-based approach, the availability and use of telehealth when appropriate, having high quality mental health providers, scheduling and service usage suggestions, and means to connect with longer-term services for ongoing mental health care when needed.