bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of IL-17 Producing Memory Regulatory and Effector T Cells Expressing CD26 Molecule in Patients with Psoriasis
Authors: Esmaeili Behnaz , Mansouri Parvin , Meysamie Alipasha , Izad Maryam
Published: January 2019

Memory regulatory T cells (Tregs) has been demonstrated to produce IL-17 in Psoriasis. Forkhead box P3 (Foxp3) has been demonstrated not to be reliable marker to evaluate Treg cells. Effector CD4+T cells also express Foxp3 after activation. Human T helper-17 cells (Th-17) express high level of surface CD26, while regulatory T cells are CD26 negative or low and this phenotype is stable even after activation of Treg cells. In this study, we aimed to analyze IL-17 producing Treg cells using CD26.     
Memory T cells were isolated from 10 patients with psoriasis and 10 controls. Ex vivo stimulated IL-17 producing regulatory (Forkhead Box P3 (Foxp3)+CD25+CD26-/low) and effector (Foxp3+CD25+CD26hi) memory T cells were analyzed by flow cytometry. IL-23, IL-6, TNFα, TGFβ and IL-17 cytokine levels were also evaluated.
No significant difference in IL-17+memory regulatory T cells was seen between patients and controls (p=0.19). A significant decrease in the percentage of IL-17 producing CD26hi effector memory T cells was observed in patients (p=0.04). However, the percentage of these cells was not different between patients with mild or severe form of psoriasis compared to controls (p=0.13). We could not find any significant difference regarding IL-23, IL-6, TNFα, TGFβ and IL-17 cytokine levels in plasma and cell culture supernatant samples between patients and controls. 
Taken together, our results showed a reduced IL-17 producing effector memory CD26hi T cells in patients with psoriasis compared to controls. However, IL-17 producing memory regulatory CD4+T cells of patients showed no significant difference from that of controls
Evaluation of ERAP1 Gene Single Nucleotide Polymorphism in Impressing the Inflammatory Cytokine Profile of Ankylosing Spondylitis Patients
Authors: Mohammadi Hamed , Babaie Farhad , Hemmatzadeh Maryam , Azizi Gholamreza , Hajaliloo Mehrzad , Ebrahimi Ali Asghar , Kazemi Tohid , Yousefi Mehdi , Rezaiemanesh Alireza , Safarzadeh Elham , Baghbani Elham , Majidi Jafar , Baradaran Behzad
Published: January 2019

Ankylosing spondylitis (AS), an autoinflammatory disease, has been associated with impaired Endoplasmic reticulum aminopeptidase (ERAP) 1 activity, which is involved in priming antigenic peptides. The purpose of this study was to evaluate if the genetic variant of ERAP1 gene could impress the inflammation status of the AS patients.
For genotyping, 140 AS cases and 140 healthy controls were enrolled. After isolation of peripheral blood mononuclear cells (PBMCs) and DNA extraction, all the subjects were genotyped for rs27044 polymorphism using SSP-PCR assay. Total RNA of PBMCs was isolated, cDNA was synthesized, and quantitative analyses of mRNA expression of cytokines were performed via Real-time PCR using the SYBR Green Gene Expression MasterMix. To measure the concentration of cytokines in serum of subjects, ELISA was used.
It was observed that the G allele of rs27044 polymorphism was significantly prevalent in AS patients. Moreover, the GG genotype and the GG+GC dominant model had significantly different distribution between study groups. There was a significant overexpression of mRNAs of IL-17A, IL-6, IL-33, TNF-α, and IFN-γ, while IL-10 was significantly downregulated in AS patients. The ELISA results were in line with that of the gene expression analysis. No significant differences in mRNA expression and concentration of cytokine were identified among AS patients with three genotypes for rs27044 SNP.
This study replicated the association of polymorphisms in ERAP1 gene with the risk of AS in a population from Iranian. However, it did not directly determine the inflammatory profile of the AS patients.
Genetic Variation in Intergenic and Exonic miRNA Sequence and Risk of Multiple Sclerosis in the Isfahan Patients
Authors: Golshani Golshani , Hojati Zohreh , Sharifzadeh Ali , Shaygannejad Vahid , Jafarinia Mojtaba
Published: January 2019

MicroRNAs (miRNAs), have been documented to perform a key role in the pathogenesis of multiple sclerosis (MS), a chronic inflammatory and autoimmune disease. Recent studies have shown that single nucleotide polymorphism in the sequence of the miRNA may change their production and expression which can lead to miRNA dysfunction and pathogenicity. Some studies have reported the relationship between miRNA polymorphism and the increased risk of autoimmune disease. This study was conducted to investigate the association between mir155 rs767649, mir196a2 rs11614913 and mir23a rs3745453 polymorphism and the risk of multiple sclerosis in the Iranian MS patients in Isfahan.
A population of 80 patients and the same number control were selected. After DNA extraction, genotyping was performed through tetra amplification refractory mutation system-PCR method (T ARMS PCR).
The frequencies of TT, TC and CC genotypes of mir23a were 46, 35 and 20% in MS patients and 42, 14 and 24 in healthy subjects respectively. These results showed that individuals carrying the genotypes of rs3745453 TC had a 2.3-fold increased risk of MS (OR=2.3, p=0.048). There was no significant difference between genotypes and allele frequency of mir155 and mir196a2 in patients and healthy controls (p>0.05).
Our findings specified that CT heterozygosity in mir23a gene significantly related with risk of MS. Unlike mir155 and mir196a2, mir23a rs3745453 may have contributed to the etiology of MS in Isfahan patients. However, extensive studies are required to gain more reliable and authentic results.
Effect of Progesterone on Expression of MMP7 and MMP13 in Lungs of Female Mice
Authors: Izadi Elahe , Vafashoar Fatemeh , Jorbozedar Paria , Assarehzadegan Mohamad Ali , Poormoghim Hadi , Kuhpayezadeh Jalil , Mojtabavi Nazanin
Published: January 2019

Gender medicine is a new era of science which focuses on the impact of sex hormones and gender on normal physiology, pathobiology and clinical features of diseases. In this study we investigated the impact of pregnancy doses of progesterone hormone on the expression of a couple of matrix metalloproteinase (MMPs), which are known to be involved in tissue remodeling of lungs in health and disease, namely MMP7 and 13. 
Pregnancy maintenance dose of progesterone was administered to female BALB/c mice for 21 and 28 days, the control group received PBS for the same days. After removal of the lungs and RNA extraction, quantitative real-time PCR was done using specific primers for MMP7 and MMP13.
We found that progesterone can slightly (not significantly) decrease the expression of MMP13 but had no effect on MMP7.
Our results shows that progesterone has minimal effect on the expression of matrix metalloproteinase7 and matrix metalloproteinase 13, but it may still have an effect on corresponding tissue inhibitor of matrix metalloproteinases (TIMPs) or other components of the Extracellular matrix  which remains to be elucidated. Also, the effect of progesterone on these MMPs can be further studied in a fibrosis model.
Social and Psychological Factors of Health and Well-being in Prayers and Narrations
Authors: Vahidi mehrjardi Shahabuddin , Zarei mahmoodabadi Mohammadhossein
Published: January 2019

The recommendations and instructions of the Prophet of Islam (PBUH) and the Imams (PBUT) as well as the effect of acting according to them are subjects of particular interest to all the believers. The explanation and description of these commands in different areas and their impacts on the health and hygiene are important for the religious and non-religious communities and can be useful for everyone. This research was carried out to determine the status of health and well-being in prayers and narrations using a combination of theology, psychology, and sociology approach.
The results of this research showed that the prayers and narrations considered the health and hygiene of human beings in all dimensions, so that acting according to the religious trainings and instructions provided by the infallibles (PBUH) can guarantee human health.
There are many instructions and suggestions in the prayers and narrations about physical and non-physical health. In the field of physical health, instructions are given for eating, drinking, marital matters, etc., observance of which ensures the human health. The orders in non-physical area can be divided into three categories of psychological, theological, and social. Most religious ethical advices (whether positive or negative) focus on the psychological health of humans, such as stinginess, envy, fear, and hypocrisy. Since belief and faith play a fundamental role in the formation and quality of behavior as well as the personality of human beings, Islam has emphasized on the appropriateness of believing systems in humans. In the area of ​​social well-being, Islam has strict orders to avoid ignorance, oppression, divisions, and covenants that can eliminate the productive and peaceful coexistence and hinder the growth of human beings. Although in this research, health and hygiene were divided into several aspects, we should have a holistic view on them.
Predictive Factors Related to the Waste Collection Behavior in Kerman City based on the Health Belief Model
Authors: Mazloomy Mahmoodabad Seyed Saeed , Movahed Ehsan , Ameri Mahboobeh , Agh Atabay Rabea , Jadgal Kheir Mohamad , Alizadeh Somayeh , Moradali  Zarepour Moradali , Hashemian Seyede Nafiseh
Published: January 2019

Introduction: Collection, secretion, and burial of waste products by scientific and economic methods are from the main problems with regard to hygiene and environment. Evaluation of the current situation and the ways that individuals, families, and industrial managers deal with this issue are basic steps towards applying the right methods in this regard. This study was carried out to predict the effective factors on the waste collection behavior in Kerman using the health belie model.
Methods: This cross-sectional descriptive survey was conducted in Kerman city in 2015. The stratified random sampling method was conducted and  400 general practitioners were selected. A researcher-made questionnaire based on the Health  Belief  Model was applied. The validity and  reliability of this questionnaire were confirmed. Data collected using descriptive statistics, Spearman correlation coefficient, and the Kruskal-Wallis test were analyzed by SPSS version 16.
Results: The results showed that the mean age of participants was 28.12 ± 1.06 years. The benefits, severity, and perceived sensitivity had the highest means, respectively. No significant relationship was found among individuals' education, awareness, and perceived sensitivity. Considering the variables of perceived barriers, benefits, and severity, the significant level was less than 0.05.  Two-thirds of the participations introduced "home" as the best place to conduct the desired behavior.
Conclusion: Perceived benefits, severity, and sensitivity were identified as the best predictors of waste collection behavior. So, in order to improve the behavior, we recommend planning based on the health belief model with an emphasis on the reduction of barriers and increase of the perceived benefits and severity.
The Relative Frequency of Bacterial Colonization on the Surfaces of Toys in Kindergartens of Yazd
Authors: Mahmodabadi Tahereh Zarei , Shiranian Mahbobeh , Hekmatimoghaddan Seyedhossein , Ehrampoush Mohamad Hassan , Shamsi Farimah
Published: January 2019

Introduction: Kindergartens are the first social environments where children are directly exposed to possible contaminations from other children. Factors such as having uncontrolled urination, putting hand, toys, and different objects into the mouth, and sharing objects with other children facilitate the spread of bacteria. The aim of this study was to determine the frequency of bacterial contamination of toys in kindergartens of Yazd city, Iran.
Methods: In this descriptive cross-sectional study, 324 samples of toys made of either cloth, wood, or plastic were collected from kindergartens at three regions of Yazd, Iran. The swab samples obtained from toys' surface were cultured directly on the bacteriologic culture media blood agar and eosin methylene blue. Specific culture medium with biochemical tests and diagnostic disks were used to determine the genus and species of bacteria. Chi-square test was run for statistical analysis of data. The  p value of < 0.05 was considered as the level of significant difference.
Results: The most common bacterial colonization of toys found in the kindergartens was Staphylococcus epidermidis (48.3%). Toys made from cloth (with 3914 CFU/cm2) and the municipality region 3 (with 4645 CFU/cm2) showed the highest amount of contamination among the toy materials and different regions, respectively.
Conclusion: Assessment of common contaminations in kindergartens may help the authorities to determine the possible causes of pediatric infections and provide them with a more comprehensive knowledge about the personal as well as environmental hygiene. So, by identification of these contaminations, we can modify the underlying factors, reduce the pollutions, and improve the health of children.
A Comparison between the Effectiveness of Social-Educational Inoculation Program Based on the Islamic Approach and Stress Inoculation Training on the Lifestyle of Second-Grade High School Female Students with Risky Behavior in Yazd City
Authors: Sadrabad Afsar , Sohrabi Faramarz , Sadipor Esmail , Delavar Ali
Published: January 2019

Introduction: Risky behaviors and unhealthy lifestyles are significantly associated with mortality of adolescents. So, this study was conducted to compare the effectiveness of social-educational inoculation program based on the Islamic approach and stress inoculation training on the lifestyle of second-grade high school female students with risky behaviors in Yazd.
Methods: This study was semi-experimental with pretest-posttest design, in which two experimental groups and one control group were investigated. The statistical population included all high school female students studying in Yazd in the academic year of 2015-2016. The participants included 54 female students with risky behaviors, who were categorized into three groups using the multistage random sampling method. Then, the groups were randomly selected as the experimental and control groups. The educational interventions were conducted in 12 sessions of one hour and 15 minutes once a week during three months. Data collection instruments were the scale of risky behaviors (Zadeh Mohammadi et al.) and lifestyle questionnaire (Laali et al.). Lifestyle questionnaires were completed by students before and after training. Data were analyzed by SPSS20 using covariance and LST.
Results: The pretest mean scores of lifestyle in the experimental group with social-educational inoculation program based on the Islamic approach was 140/77, with stress inoculation training was 139.27, and the mean score of the control group was 141.55.I In posttest, these mean scores were 156.83, 139.22, and 140.94, respectively. The results showed that the lifestyle mean scores improved in participants who attended the social-educational inoculation program based on Islamic approach (sig= 0/001). However, the participants who attended the stress inoculation training did not have any significantly difference in this regard (sig=0/085).
Evaluation of Seroepidemiology of Toxoplasmosis in HIV + patients referring to the Treatment Centers of Yazd in 2014
Authors: Mousavi Seyed Alireza , Sajadi Golmehrsadat , Ayatollahi Jamshid , Vakili Mahmood , Shahcheraghi Seyed Hossein
Published: January 2019

Introduction: Considering the increasing rate of HIV virus in human societies and given the immune deficiency in HIV positive people, the prevalence of infections such as toxoplasmosis has been higher among these patients. In other words, in the case of not treating this infection, it can be fatal. Furthermore, due to favorable conditions provided for the parasite in these hosts, the presence of species resistant to treatment or with pathogenesis is more probable. This risk threatens the entire community. So, the aim of this study was to evaluate seroepidemiology of toxoplasmosis in HIV positive patients, who referred to the Treatment Centers of Yazd in 2014
Method: This  cross-sectional study was conducted on 84 patients with HIV in behavioral health counseling centers in Yazd. In this study, IgG antibodies were measured by ELISA and CD4 cell counts methods using the flow-cytometry for all patients. Chi-square test was run to evaluate the relationship between the prevalence of toxoplasmosis in terms of independent variables at a significance level of 5 percent.
Results: We found that 4.52 percent of patients had positive IgG results. No significant difference was observed in the prevalence of toxoplasmosis in the studied patients and variables, such as gender, age, drug addiction, and income (p-value > 0.05). Considering the transfer of the disease, results of this study showed that 3 cases (3.6%), 20 cases (23.8%), and 57 cases (67.9%) of the disease transmitted from mother to child, spouse, and the person him/her-self, which included 95.3 percent. The disease transmission method was not determined in other four patients.
Conclusion:High risk groups of society, especially people with intravenous addiction and high-risk sexual contacts should be informed and screened about the risk factors of contamination with HIV. In this regard, logical and practical planning, educational programs, and treatment measures are required to reduce the high-risk behaviors among this group.
Publiczny Obrońca Praw Republiki Czeskiej jako organ do spraw równości w kontekście standardów wyznaczanych przez dyrektywy Unii Europejskiej
Authors: Gajda Agnieszka
Published: January 2019

Przedmiotem niniejszego opracowania jest ocena działalności Publicznego Obrońcy Praw Republiki Czeskiej w zakresie wykonywania działań powierzonych mu od 2009 roku jako krajowemu organowi do spraw równości. Ma on przyczyniać się do promowania prawa do równego traktowania wszystkich osób bez względu na ich rasę, pochodzenie etniczne, narodowość, płeć, orientację seksualną, wiek, niepełnosprawność, religię, przekonania czy poglądy. W tym zakresie działa według postanowień Konstytucji Republiki Czeskiej, Karty Podstawowych Praw i Wolności, tzw. ustawy antydyskryminacyjnej oraz wielu innych ustaw. Zadania te zostały ombud­smanowi powierzone w ramach stosowania dyrektyw Unii Europejskiej. Podkreślano w nich, że jednym ze sposobów wzmocnienia ochrony przed dyskryminacją w państwach członkowskich UE jest powołanie organów, których zadaniem byłoby analizowanie problemów związanych z dyskry­minacją, badanie możliwych rozwiązań i świadczenie konkretnej pomocy ofiarom. Autorka niniej­szego opracowania zastanawia się, czy Publiczny Obrońca Praw spełnia wymogi stawiane krajo­wym organom do spraw równości, powołując się na kryteria określone w tzw. zasadach paryskich, które w sposób szczegółowy określają aspekt niezależności funkcjonowania instytucji stojących na straży praw człowieka. Ponadto przedstawia podstawowe założenia, na których opiera się dzia­łalność czeskiego ombudsmana oraz informacje dotyczące praktyki jego działalności w obszarze zapewnienia realizacji zasady równości.
Między naukowością a populizmem penalnym. Kilka uwag o socjalizacji prawnej w kontekście polskich regulacji przestępstw seksualnych
Authors: Gaczoł Klaudia
Published: January 2019

Celem artykułu jest analiza zjawiska socjalizacji prawnej w kontekście polskich regulacji przestępstw seksualnych. Pozwoli to stwierdzić, czy podejmowane działania prawodawcze odpowiadają aktualnym potrzebom społecznym i przede wszystkim – czy odnoszą zamierzone skutki. Świadomość prawna oraz internalizacja wartości zawartych w obowiązujących normach prawnych ma w tym procesie znaczenie fundamentalne. Stosunek obywateli do funkcjonującego w państwie systemu karnego jest zatem zjawiskiem kluczowym, nierozerwalnie związanym z wciąż ewoluującymi poglądami na karę. Warto więc zastanowić się nad tym, czy socjalizacja prawna rzeczywiście ma znaczenie dla społecznej percepcji prawa oraz poziomu i rodzaju jego legitymizacji wśród społeczeństwa. Zagadnienie to wydaje się być szczególnie atrakcyjne chociażby z uwagi na formułowane w Polsce od lat tezy o „kryzysie prawa” i braku jego naukowej legitymizacji. Nie bez znaczenia dla omawianego tu zjawiska jest również wpływ mediów na postawy społeczne, kształtowanie się stereotypów dotyczących działania prawa i wymiaru sprawiedliwości oraz penalnopopulistyczna retoryka, która dodatkowo pogłębia alienację środowiska naukowego.
Fluxos migratórios, comunicação e cidadania: vivências de imigrantes LGBT na cidade de São Paulo
Authors: Theodoro Hadriel , Cogo Denise
Published: January 2019

O trabalho objetiva refletir acerca das experiências de vida de imigrantes lésbicas, gays, bissexuais, travestis, transexuais e transgêneros que residem no Brasil, mais especificamente, na cidade de São Paulo. O enfoque recai sobre as dinâmicas comunicacionais e sua relação com o exercício da cidadania por parte desses/as imigrantes. Para tanto, tomamos como objeto empírico suas próprias vivências, acessadas por meio de narrativas autobiográficas. Apresentamos e analisamos aqui os relatos de uma mulher lésbica americana e de uma mulher transgênero finlandesa. No que concerne aos procedimentos metodológicos, eles estão pautados na realização de entrevistas semiestruturadas e em uma análise textual, orientada pela análise do discurso de linha francesa. Os apontamentos principais problematizam as discriminações, precariedades e violências a pessoas lésbicas, gays, bissexuais, travestis, transexuais e transgêneros em nosso país, as (in)visibilidades presentes no processo migratório e as questões de cidadania aí englobadas.
Editorial
Authors: Vanz Samile Andréa de Souza
Published: January 2019

Editorial
Áreas do conhecimento em que as universidades do Sul do Brasil possuem patentes concedidas
Authors: Stefani Cativelli Adriana , Barbosa Vianna William , Pinto Adilson Luiz
Published: January 2019

O estudo tem como objetivo geral analisar as patentes concedidas nas universidades públicas do Sul do Brasil no que se refere às áreas do conhecimento – de onde provêm, e em quais áreas elas são classificadas de acordo com a Classificação Internacional de Patentes - e como objetivos específicos mapear as universidades públicas do Sul do país e suas patentes; identificar as áreas da Classificação Internacional de Patentes e as áreas do conhecimento do Conselho Nacional de Desenvolvimento Científico e Tecnológico, às quais as patentes pertencem; e estabelecer relação de contribuição que cada área do conhecimento do Conselho Nacional de Desenvolvimento Científico e Tecnológico realiza em cada área da Classificação Internacional de Patentes. O levantamento das patentes foi realizado na base de dados do Instituto Nacional da Propriedade Industrial. De posse do número da classificação, realizou-se o cruzamento com as áreas do conhecimento da tabela do Conselho Nacional de Desenvolvimento Científico e Tecnológico. Os resultados reuniram 11 universidades públicas que apresentaram 68 patentes concedidas. A seção da Classificação Internacional de Patentes que apresentou maior número de concessões de patentes foi a “C - Química; Metalurgia”, com 25 registros. As áreas de conhecimento do  Conselho Nacional de Desenvolvimento Científico e Tecnológico que publicaram na seção foram: Bioquímica, Engenharia Civil, Engenharia de Materiais e Metalúrgica, Engenharia Química, Engenharia Sanitária e Química. A grande área "Engenharias" foi a que obteve o maior volume de patentes, totalizando 24. A formação dos inventores mais produtivos, que pertencem à Universidade Federal do Rio Grande do Sul, concentrou-se na área de Química.
O produtivismo acadêmico na vida dos discentes de pós-graduação
Authors: Estácio Letícia Silvana dos Santos , Andrade Wemylinn Giovana Florencio , Kern Vinícius Medina , Cunha Cristiano Jose Castro de Almeida
Published: January 2019

O produtivismo acadêmico é um fenômeno caracterizado pela excessiva valorização da quantidade e pela escassa consideração da qualidade da produção acadêmica. O objetivo deste artigo é compreender a influência do produtivismo acadêmico na vida dos discentes de um curso de pós-graduação a partir de suas percepções.  O estudo utilizou o método qualitativo fundamentado na entrevista em profundidade e na análise temática dos dados. Foram entrevistados dez discentes. Os discentes consideram o produtivismo acadêmico tanto positivo quanto negativo. Do ponto de vista positivo, argumentam que a cobrança por produzir contribui no processo de construção do conhecimento, e do lado negativo, que a pressão para publicar em quantidade exige intensa dedicação, gerando, em muitos casos, problemas psicológicos, emocionais e físicos.
O papel social do bibliotecário voltado às pessoas trans
Authors: Goulart Righetto Guilherme , Figueiredo Vieira da Cunha Miriam , Vieira Vitorino Elizete
Published: January 2019

Este trabalho analisa, mediante revisão da literatura, o papel social do bibliotecário e da biblioteca voltado às pessoas trans. Ele enfatiza a competência em informação como prática social do bibliotecário, bem como aponta a inexpressividade, em âmbito brasileiro, das iniciativas voltadas para com a população trans e de lésbicas, gays, bissexuais e outros. Também reafirma a necessidade da participação, a partir de suas práticas profissionais, no progresso político, socioeconômico, informacional e de resistência das classes minoritárias, apontando o protagonismo social, o empoderamento, a liberdade e a emancipação como fatores necessários ao desenvolvimento pessoal, profissional e social dos indivíduos. Como resultados do estudo, apontam-se a urgência da adesão política bibliotecária frente às minorias sociais, devendo-se focalizar e priorizar nas abordagens sociais (inclusão, cidadania e inclusão digital), principalmente em países em desenvolvimento, como o Brasil. Conclui-se que o papel social bibliotecário deve possibilitar vivenciar, captar e buscar suprir as necessidades de informação do modo que lhe compete, ao mesmo modo em que as bibliotecas e as unidades de informação contemporâneas têm de se apresentarem criativas, inovadoras e livres de preconceitos, visando o êxito ao lidar com as complexidades humanas e tecnológicas.
Organização e representação do conhecimento arquivístico: em busca de um método para construção de tesauro funcional
Authors: Alencar Maíra Fernandes , Cervantes Brígida Maria Nogueira
Published: January 2019

A produção e o uso do conhecimento arquivístico no cenário das Tecnologias de Informação e Comunicação apresentam um ambiente complexo. Assim, refletir sobre as formas de representar o conhecimento arquivístico com instrumentos terminológicos contribui para o acesso informacional. Nessa perspectiva, os tesauros funcionais, como campo de estudo dentro da área, atuam como uma ferramenta complementar de solução aos problemas de acesso à informação arquivística. Em vista disso, este trabalho tem como objetivo realizar uma sistematização metodológica da construção de um tesauro funcional. Quanto aos procedimentos metodológicos, caracterizam-se como pesquisa bibliográfica e exploratória com abordagem qualitativa. Utiliza-se o método de análise de conteúdo de Bardin, que após a pré-análise e a exploração do material (literatura técnico-científica) agrupou-se as categorias: natureza pragmática conceitual, aspectos preliminares necessários e funções que o tesauro desempenha, além do aspecto teórico evidenciado, etapas e ações fundamentais para a construção do tesauro funcional. Verificou-se que, para a construção dos tesauros funcionais, o manual do Arquivo Nacional da Austrália, pioneiro em manual de tesauro funcional, descreve passos e ações necessárias para a sua construção. Conclui-se que essa trajetória da construção do tesauro funcional caminha por um estágio inicial, revelando a necessidade de aprofundamento teórico dessa temática junto a outras áreas do conhecimento.
Um estudo sobre a rede de colaboração científica dos pesquisadores brasileiros com currículos cadastrados na Plataforma Lattes
Authors: Dias Thiago Magela Rodrigues , Moita Gray Farias , Dias Patricia Mascarenhas
Published: January 2019

As análises sobre as redes de colaboração científica vêm sendo amplamente exploradas em pesquisas de diversas áreas do conhecimento há algum tempo, tendo em vista a sua capacidade de identificar como grupos de pesquisadores têm realizado seus trabalhos coletivamente. Tais estudos possibilitam identificar como ocorre a colaboração entre os indivíduos através de análises baseadas em métricas de redes sociais. Neste trabalho, inicialmente é apresentada uma caracterização geral do conjunto analisado e, após, é realizada uma análise temporal da rede de colaboração científica dos doutores brasileiros com currículos cadastrados na Plataforma Lattes. Para isso, todas as publicações científicas dos doutores foram utilizadas para a identificação e caracterização das redes de colaboração. Como resultado, é possível visualizar como a colaboração científica do conjunto analisado foi sendo intensificada ao longo dos anos, com destaque para as grandes áreas de atuação de cada doutor.
Reasons in favor of a Hubble-Lemaître-Slipher's (HLS) Law
Authors: Elizalde Emilio
Published: January 2019

Based on historical facts, revisited from a present-day perspective, and on the documented opinions of the scientists involved in the discovery themselves, strong arguments are given in favor of a proposal to include prominent astronomer Vesto Slipher to the suggested addition of Georges Lemaître's name to Hubble's law on the expansion of the Universe, and thus eventually call it Hubble-Lemaître-Slipher's (HLS) law.
Electronic Structure Calculations of Oxygen Atom Transport Energetics in the Presence of Screw Dislocations in Tungsten
Authors: Zhao Yue , Dezerald Lucile , Marian Jaime
Published: January 2019

Plastic flow in body-centered cubic (bcc) alloys is governed by the thermally-activated screw dislocation motion. In bcc interstitial solid solutions, solute diffusion can occur at very fast rates owing to low migration energies and solute concentrations. Under mechanical loading, solutes may move on the same or similar time scale as dislocations glide, even at low temperatures, potentially resulting in very rich co-evolution processes that may have important effects in the overall material response. It is therefore important to accurately quantify the coupling between interstitial impurities and dislocations, so that larger-scale models can correctly account for their (co)evolution. In this paper, we use electronic structure calculations to obtain the energetics of oxygen diffusion under stress and its interaction energy with screw dislocation cores in bcc tungsten. We find that oxygen atoms preferentially migrate from tetrahedral to tetrahedral sites with an energy of 0.2 eV. This energy couples only weakly to hydrostatic and deviatoric deformations, with activation volumes of less than $0.02$ and $0.2b^3$, respectively. The strongest effect is found for the inelastic interaction between O atoms and screw dislocation cores, which leads to attractive energies on the order of 1.5 eV and a structural transformation of the screw dislocation core from an `easy' to a `hard' core configuration
A One-Year Prospective Follow-Up Study on the Health Profile of Hikikomori Living in Hong Kong
Authors: Yuen John , Wong Victor , Tam Wilson , So Ka-Wing , Chien Wai-Tong
Published: January 2019

Background: A prospective study was conducted to follow-up how the living lifestyle of hikikomori could change the social, mental and physical health profile. Methods: A cohort consisted of 104 young people living as Hikikomori were interviewed at baseline, 6 months and 12 months by using the same set of questionnaires and anthropometric measurements. Results: Besides the high attrition of 30% in wave 2 and 25% in wave 3, almost half of the participants have recovered from hikikomori by returning to the workforce in society. The three domains of health profile of hikikomori were significantly improved over the follow-up period by: 1) increasing the social network scores from 2.791.80 to 3.091.87, 2) decreasing the perceived stress scores from 21.185.87 to 20.115.79, and 3) reducing blood pressure levels from 118/75 to 115/71 and waist-to-hip ratios. Those variables were also predictable by lifestyle living with the hikikomori according to the Generalized Estimating Equation analysis, whereas the participants of current study had increased the practice of moderate-intensity exercises. Conclusion: Social work intervention was effective in helping the recovery of hikikomori while physical assessments followed by encouragement from social workers to do more exercises might enhance their awareness in health modification towards a better health.
ANALYSIS OF STUDENT’S BOOK ON FOURTH GRADE BASED ON CURRICULUM 2013 THEMES "MY HEROES" SUBTEMA "THE STRUGGLE OF THE HEROES"
Authors: Indriasari Bernadine Ajeng
Published: January 2019

The purpose of this research is to know stundent’s book of four grade student based on Curricullum 2013 on theme “Pahlawanku” subtheme “Perjuangan Para Pahlawan” on lesson 3with kompetensi dasar, purpose, indicator, learning activity, materials, tool and learning resources. Research method is descriptive method by analyze document is student book of four grade student based on Curricullum 2013 on theme “Pahlawanku” and teacher book of four grade student based on Curricullum 2013. The analize revolves on the rule of Menteri Pendidikan dan Kebudayaan Nasional, an article discussing about the implementation of Curricullum 2013 and article from Badan Nasional Standar Pendidikan (BSNP) website. The result of this research are found that some kompetensi dasar do not appear in indicators and materials that are less in line with the mapping of kompetensi dasar. From the analysis it is conclude that the student’s book of four grade student based on Curricullum 2013 on theme “Pahlawanku” subtheme “Perjuangan Para Pahlawan”needs much improved with the discrepancies inlesson 3.
Variantes de autor en la poesía impresa de Montemayor
Authors: MONTERO Juan
Published: January 2019

En el contexto de la transmisión textual de la poesía del Siglo de Oro, Jorge de Montemayor es uno de los rarísimos autores que llevaron a cabo correcciones redaccionales en las sucesivas impresiones de sus versos a lo largo de su vida. En este trabajo se analizan algunos casos relacionados con la expresión de la espiritualidad en sus poemas tanto profanos como devotos.
Emilio Prados: las dos versiones de Jardín cerrado
Authors: CARREIRA Antonio
Published: January 2019

Examen de algunos poemas de Jardín cerrado (1946), que en su segunda edición (1960) presentan variantes sustanciales.
Juan Rufo, Alonso de Ercilla y la épica virreinal desde una perspectiva transatlántica
Authors: De Navascués Javier
Published: January 2019

El presente artículo compara La Austríada de Juan Rufo, en tanto que epítome de los poemas peninsulares de tiempos del Imperio español en Europa, y la épica colonial en verso escrita a finales del siglo XVII. Mientras que Rufo se refiere al enemigo de la fe en la linde entre España y el mar Mediterráneo, los poemas compuestos al otro lado del charco expanden sus espacios e incluyen nuevos enemigos, tales como los indígenas y los piratas. Asimismo, la poesía épica colonial propone diferentes medidas que conciernen a las poderosas relaciones entre América y España, según se evidencia en La Araucana de Alonso de Ercilla.
Materiam superabat opus: Cervantes, cautivo lector de Rufo (al trasluz de la modalidad épico-novelesca en La Austríada y los Apotegmas)
Authors: Escobar Francisco J.
Published: January 2019

El presente estudio arroja luz sobre el método épico-novelesco empleado por Miguel de Cervantes en su conocida historia del cautivo. Para ello, el autor del Quijote fue un atento lector de Juan Rufo, quien, entre la realidad histórica y la ficcionalización, cultivó tanto el canon épico como la tradición paremiológica, según queda de manifiesto en La Austríada y Apotegmas. Sin embargo, Cervantes supo encontrar, además, sus propias señas de identidad narrativas con el objeto de “mostrar con propiedad un desatino”, entre otras estrategias humanísticas, gracias a su profundo conocimiento y asimilación de los modelos de la tradición clásica.
Evaluation of the effect of oral taurine supplementation on levels of fibroblast growth factors, β-Klotho co-receptor, some biochemical indices and body composition in obese women on a weight-loss diet: a study protocol for a double-blind randomized controlled trial
Authors: Haidari Fatemeh , Asadi Maryam , Mohammadi-asl Javad , Ahmadi-angali Kambiz
Published: January 2019

Background: According to studies, the function of FGFs are disturbed in obesity. So that, serum level of FGFs are correlated with insulin resistance and obesity. Besides the effects of eicosapentaenoic acid on serum FGF21 concentrations, the effect of other nutrients on FGFs is not clear. Since obesity as an important health problem is rising in the world and on the other side, taurine (Tau) biosynthesis is reduced by adipose tissue-derived factors in obesity, the effects of Tau and a weight loss diet on obesity need to be investigated further.
Methods: We will conduct a 2 month’s double-blind, parallel-group, randomized controlled clinical trial to investigate the effect of Tau supplementation on serum levels of fibroblast growth factors, β-Klotho co-receptor, some biochemical indices and body composition in obese women on a weight-loss diet.
Discussion: We will determine the other advantages of a weight loss diet on metabolic risk factors. Moreover, for the first time, the effects of a weight loss diet along with Tau supplementation on these variables will be assessed.
Trial Registration: Iran clinical trials registry, IRCT20131125015542N2. Registered on Nov 11, 2018.
Keywords: Taurine supplementation, weight loss diet, fibroblast growth factors, obesity.
Descemet’s Membrane Endothelial Keratoplasty for Pseudoexfoliation Syndrome: A Case Series
Authors: Tase Saho , Shimizu Toshiki , Hayashi Takahiko , Tabuchi Hitoshi , Niimi Koji , Mizuki Nobuhisa , Kato Naoko
Published: January 2019

BacKground: To evaluate the clinical outcomes and features of Descemet’s membrane endothelial keratoplasty (DMEK) for eyes with pseudoexfoliation syndrome (PEX).
Methods: In this retrospective study, 37 DMEK cases were reviewed from available medical records. Patients who exhibited endothelial dysfunction derived from PEX or Fuchs endothelial corneal dystrophy (FECD) and successfully underwent cataract surgery about four weeks before DMEK were enrolled. The best spectacle-corrected visual acuity (BSCVA), central corneal thickness (CCT), endothelial cell density (ECD), and incidence of intra-operative/post-operative complications of DMEK were analyzed.
Results: This study included 14 eyes of 14 patients (PEX: n=6, FECD: n=8). There was no primary graft failure. In the PEX group, BSCVA improved from 0.67 ± 0.28 at the preoperative point to 0.43 ± 0.14 at 1 month, 0.27 ± 0.10 at 3 months, and 0.19 ± 0.08 at 6 months after DMEK. The donor corneal ECD was 2,704 ± 225 cells/mm2 at the preoperative point and decreased to 1,691 ± 498 cells/mm2 at 1 month, 1,425 ± 366 cells/mm2 at 3 months, and 1,281 ± 340 cells/mm2 (52.7 ± 11.7% less than ECD of the donor graft) at 6 months after DMEK. None of the patients required rebubbling. When compared with the FECD group, no statistical difference was observed in CCT (p=0.821); BSCVA (p=0.001) and the reduction rate of ECD (p=0.010) were relatively worse.
Conclusions: DMEK is effective for the treatment of endothelial dysfunction due to PEX.
Keywords: Descemet’s membrane endothelial keratoplasty, pseudoexfoliation syndrome, bullous keratopathy, endothelial keratoplasty
High Tunability of Size Dependent Optical Properties of ZnO@M@Au (M = SiO2, In2O3, TiO2) Core/Spacer/Shell Nanostructure
Authors: Kassahun Gashaw Beyene
Published: January 2019

This theoretical work presents a comparative study of high tunability size dependent optical properties of quantum dot/wire triple layered core shell nanostructure based on the quasi-static approximation of classical electrodynamics embedded in a fixed dielectrics function of host matrix. In this paper, local field enhancement factor (LFEF), refractive index and optical absorbance of nanocomposite are analyzed by varying core size, thickness of spacer and shell as well as dielectrics function of the spacer for the size of the nanocomposite with the range of 20 nm to 40 nm. For both quantum dot and quantum wire triple layered core shell nanostructure (CSNS), there are two resonances in visible and near/in infrared spectral region with high tunability. When the shell thickness increase and therefore increasing the gold content, the surface plasmon resonance (SPR) at the outer interface shifts to higher energy (blue-shifted) and at the inner interface weak peaks and shifted to lower energy (red-shifted). All of three optical properties, depend on core size, dielectrics and thickess of spacer, thickness of shell, shape of composite and filling factor. For the same thickness of spacer and shell of the two configurations, cylindrical triple layered CSNS less pronounced and shifted to infrared red (IR) spectral region which is recommendable for biological and photocatalysis application.
Oxidative Stress, Ocular Disease and Diabetes Retinopathy
Authors: Tangvarasittichai Orathai , Tangvarasittichai Surapon
Published: January 2019

Background:

Oxidative stress is caused by free radicals or oxidant productions, including lipid peroxidation,
protein modification, DNA damage and apoptosis or cell death and results in cellular degeneration and
neurodegeneration from damage to macromolecules.

Results:

Accumulation of the DNA damage (8HOdG) products and the end products of LPO (including aldehyde,
diene, triene conjugates and Schiff’s bases) were noted in the research studies. Significantly higher levels of these
products in comparison with the controls were observed. Oxidative stress induced changes to ocular cells and
tissues. Typical changes include ECM accumulation, cell dysfunction, cell death, advanced senescence, disarrangement
or rearrangement of the cytoskeleton and released inflammatory cytokines. It is involved in ocular
diseases, including keratoconus, Fuchs endothelial corneal dystrophy, and granular corneal dystrophy type 2,
cataract, age-related macular degeneration, primary open-angle glaucoma, retinal light damage, and retinopathy of
prematurity. These ocular diseases are the cause of irreversible blindness worldwide.

Conclusions:

Oxidative stress, inflammation and autophagy are implicated in biochemical and morphological
changes in these ocular tissues. The development of therapy is a major target for the management care of these
ocular diseases.
Effects of CYP2C8 and SLCO1B1 Genetic Polymorphisms on Repaglinide Pharmacokinetics: A Systematic Review and Meta-Analysis
Authors: Zhou Shuang , Xiang Qian , Mu Guangyan , Ma Lingyue , Chen Shuqing , Xie Qiufen , Zhang Zhuo , Cui Yimin
Published: January 2019

Objective:

The purpose of this systematic review and meta-analysis was to summarize the potential impact
of CYP2C8 and SLCO1B1 genetic polymorphisms on repaglinide pharmacokinetics.

Methods:

A systematic search was conducted using electronic databases. Eligible studies reported data from pharmacokinetic
evaluations of repaglinide in healthy adults according to different categories of CYP2C8 and SLCO1B1
genetic polymorphisms.

Results:

Six studies including a total of 191 participants met the inclusion criteria. We noted that CYP2C8 *1/*3 carriers exhibited lower AUC(0-∞) (SMD: -0.77; 95%CI: -1.23 to -0.30; P=0.001) and Cmax (SMD: -0.94; 95%CI: - 1.41 to -0.47; P<0.001) than CYP2C8 *1/*1 carriers. There were no significant differences in AUC(0-∞), Cmax, t1/2 and mean change in blood glucose concentration between *1/*4 and *1/*1 carriers. Further, *3/*3 carriers had lower Cmax (SMD: -1.42; 95%CI: -2.66 to -0.17; P=0.026) than *1/*1 carriers. Additionally, *3/*3 carriers had lower Cmax than *1/*3 carriers (SMD: -1.20; 95%CI: -2.40 to -0.00; P=0.050). Finally, we noted that repaglinide pharmacokinetics did not differ by SLCO1B1 genotype.

Conclusion:

The current systematic review and meta-analysis indicated that the genotype of CYP2C8, but not
SLCO1B1, may affect repaglinide pharmacokinetics. However, because of the comparatively insufficient number of
published studies included, our conclusions require support from additional studies.
Biochemical and Structural Insights into the Eukaryotic Translation Initiation Factor eIF4E
Authors: Volpon Laurent , Osborne Michael J. , Borden Katherine L.B.
Published: January 2019

A major question in cell and cancer biology is concerned with understanding the flow of
information from gene to protein. Indeed, many studies indicate that the proteome can be decoupled
from the transcriptome. A major source of this decoupling is post-transcriptional regulation. The eukaryotic
translation initiation factor eIF4E serves as an excellent example of a protein that can modulate
the proteome at the post-transcriptional level. eIF4E is elevated in many cancers thus highlighting
the relevance of this mode of control to biology. In this review, we provide a brief overview of various
functions of eIF4E in RNA metabolism e.g. in nuclear-cytoplasmic RNA export, translation,
RNA stability and/or sequestration. We focus on the modalities of eIF4E regulation at the biochemical
and particularly structural level. In this instance, we describe not only the importance for the m7Gcap
eIF4E interaction but also of recently discovered non-traditional RNA-eIF4E interactions as well
as cap-independent activities of eIF4E. Further, we describe several distinct structural modalities used
by the cell and some viruses to regulate or co-opt eIF4E, substantially extending the types of proteins
that can regulate eIF4E from the traditional eIF4E-binding proteins (e.g. 4E-BP1 and eIF4G). Finally,
we provide an overview of the results of targeting eIF4E activity in the clinic.
Scaphoid Motion of the Wrist with Scapho-trapezio-trapezoidal Osteoarthritis-A Pilot Study
Authors: Wollstein Ronit , Moritomo Hisao , Akio Iida , Omokawa Shohei
Published: January 2019

Background:

The purpose of this study was to investigate scaphoid motion within the
scapho-trapezio-trapezoidal (STT) joint during wrist motion in the presence of STT joint osteoarthritis
(OA).

Methods:

We studied 11 wrists with STT OA and 5 normal wrists. Computed tomography (CT)
images were acquired in five wrist positions (maximum active flexion, extension, radial deviation,
ulnar deviation, and neutral position). The 3-dimensional surface models of the radius and scaphoid
were constructed and the motion of scaphoid relative to the radius was calculated.

Results and Conclusion:

During wrist flexion/extension motion, the scaphoid rotated mostly in
the flexion/extension plane. The angle tended to be smaller in STT OA than in normal. During
wrist radioulnar deviation, the scaphoid was in an extended position in neutral wrist in STT OA.
The motion of scaphoid in STT OA was divided into two types: a rigid type and mobile type. The
mobile type rotated closer to the flexion/extension plane than the rigid type. Taking into account
scaphoid motion during wrist movement before surgery may provide better results in the treatment
of STT OA.