bluuebunny/crossref_metadata_2025 huggingface dataset:
The Moderating Role of the Hostile-World Scenario in the Connections Between COVID-19 Worries, Loneliness, and Anxiety
Authors: Bergman Yoav S. , Shrira Amit , Palgi Yuval , Shmotkin Dov
Published: March 2021

The COVID-19 pandemic has had pronounced effects on individuals' psychological well-being around the world. Concerns regarding the consequences of infection, as well as the general uncertainty and governmental regulations have resulted in increased psychological distress among many populations and cultures. In this regard, research has shown that the manner by which individuals perceive such large-scale threats and appraise them significantly contributes to the psychological consequences of such events. According to the Hostile-World Scenario (HWS) model, negative engagement (NE) with such threats weakens one's competence and coping abilities, whereas positive engagement (PE) facilitates resilience and enhances psychological adjustment. Accordingly, the current study examines the moderating role of both NE and PE in the connections of two main features of the current pandemic, COVID-19-related worries and loneliness, with anxiety. Data were collected between March 16 and April 14, 2020, from 1,112 Israelis (age range 17–92, M = 46.90, SD = 16.46), who provided information regarding COVID-19 health worries, loneliness, and anxiety. A special measure assembled items pertinent to the HWS-NE and HWS-PE throughout the survey. Results demonstrated that both HWS-NE and HWS-PE were significant moderators. COVID-19-related health worries/loneliness were linked with anxiety only among individuals with high HWS-NE, and were non-significant among those with low HWS-NE. Moreover, the positive association between loneliness and anxiety was significantly mitigated by high HWS-PE. The discussion highlights the importance of the HWS for understanding the psychological consequences of COVID-19 and offers practical suggestions, which may aid mental health practitioners in providing assistance and support to the general population.
A Moderated Mediation Effect of Stress-Related Growth and Meaning in Life in the Association Between Coronavirus Suffering and Satisfaction With Life: Development of the Stress-Related Growth Measure
Authors: Yıldırım Murat , Arslan Gökmen
Published: March 2021

As previous pandemics, the coronavirus disease 2019 (COVID-19) has direct and indirect effects on mental health and well-being. The purpose of the current study was to examine whether meaning in life mediated the association between coronavirus suffering and satisfaction with life and whether stress-related growth moderated the mediating effect of meaning in life on the association between these variables. Stress-Related Growth Measure (SGM) was also conducted for the purpose of this study. The participants were 402 (66% women) young adults who completed the Suffering Measure During COVID-19, Meaningful Living Measure, Satisfaction With Life Scale, and SGM. The results indicated that the SGM has adequate psychometric properties with unidimensional structure of stress-related growth in the face of adversity. Moderated mediation analysis revealed that coronavirus suffering directly influenced satisfaction with life as well as indirectly by its effect on meaning in life. Additionally, stress-related growth was found as a moderator in the relationship between coronavirus suffering–meaning in life and coronavirus suffering–satisfaction with life. These results suggest that meaning in life mitigates the effect of coronavirus suffering on satisfaction with life, and this mediating effect is moderated by stress-related growth in young adults. While meaning in life helps explain the relationship between coronavirus suffering and satisfaction with life, the stress-related growth functions as a protective factor against the adverse effect of coronavirus experiences.
Patient Perspectives on Hospital Falls Prevention Education
Authors: Heng Hazel , Slade Susan C. , Jazayeri Dana , Jones Cathy , Hill Anne-Marie , Kiegaldie Debra , Shorr Ronald I. , Morris Meg E.
Published: March 2021

Hospital falls remain an intractable problem worldwide and patient education is one approach to falls mitigation. Although educating patients can help their understanding of risks and empower them with prevention strategies, patient experiences of hospital falls education are poorly understood. This study aimed to understand the perspectives and preferences of hospitalized patients about falls prevention education. Three focus groups were conducted in Australian hospitals. A phenomenological approach was used to explore patient perspectives and data were analyzed thematically. The focus groups revealed that most people did not realize their own risk of falling whilst an inpatient. Experiences of falls prevention education were inconsistent and sometimes linked to beliefs that falls were not relevant to them because they were being cared for in hospital. Other barriers to falls mitigation included poor patient knowledge about hospital falls risk and inconsistencies in the delivery of falls prevention education. A strong theme was that individualized, consistent education, and small interactive groups were helpful.
Simulation of COVID-19 Propagation Scenarios in the Madrid Metropolitan Area
Authors: Singh David E. , Marinescu Maria-Cristina , Guzmán-Merino Miguel , Durán Christian , Delgado-Sanz Concepción , Gomez-Barroso Diana , Carretero Jesus
Published: March 2021

This work presents simulation results for different mitigation and confinement scenarios for the propagation of COVID-19 in the metropolitan area of Madrid. These scenarios were implemented and tested using EpiGraph, an epidemic simulator which has been extended to simulate COVID-19 propagation. EpiGraph implements a social interaction model, which realistically captures a large number of characteristics of individuals and groups, as well as their individual interconnections, which are extracted from connection patterns in social networks. Besides the epidemiological and social interaction components, it also models people's short and long-distance movements as part of a transportation model. These features, together with the capacity to simulate scenarios with millions of individuals and apply different contention and mitigation measures, gives EpiGraph the potential to reproduce the COVID-19 evolution and study medium-term effects of the virus when applying mitigation methods. EpiGraph, obtains closely aligned infected and death curves related to the first wave in the Madrid metropolitan area, achieving similar seroprevalence values. We also show that selective lockdown for people over 60 would reduce the number of deaths. In addition, evaluate the effect of the use of face masks after the first wave, which shows that the percentage of people that comply with mask use is a crucial factor for mitigating the infection's spread.
On the Psychology of TikTok Use: A First Glimpse From Empirical Findings
Authors: Montag Christian , Yang Haibo , Elhai Jon D.
Published: March 2021

TikTok (in Chinese: DouYin; formerly known as musical.ly) currently represents one of the most successful Chinese social media applications in the world. Since its founding in September 2016, TikTok has seen widespread distribution, in particular, attracting young users to engage in viewing, creating, and commenting on “LipSync-Videos” on the app. Despite its success in terms of user numbers, psychological studies aiming at an understanding of TikTok use are scarce. This narrative review provides a comprehensive overview on the small empirical literature available thus far. In particular, insights from uses and gratification theory in the realm of TikTok are highlighted, and we also discuss aspects of the TikTok platform design. Given the many unexplored research questions related to TikTok use, it is high time to strengthen research efforts to better understand TikTok use and whether certain aspects of its use result in detrimental behavioral effects. In light of user characteristics of the TikTok platform, this research is highly relevant because TikTok users are often adolescents and therefore from a group of potentially vulnerable individuals.
Health-Related Quality of Life and Its Influencing Factors for Elderly Patients With Hypertension: Evidence From Heilongjiang Province, China
Authors: Zheng Erwei , Xu Jiao , Xu Juan , Zeng Xueyun , Tan Wan Jie , Li Jinmei , Zhao Miaomiao , Liu Bo , Liu Rui , Sui Mingjie , Zhang Zhong , Li Yang , Yang Hongbin , Yu Hongjuan , Wang Yongqing , Wu Qunhong , Huang Weidong
Published: March 2021

Objective: Hypertension is one of the most common public health issues worldwide. However, few existing studies examining health-related quality of life (HRQoL) were conducted on elderly patients with hypertension in China. Hence, this study aimed to assess the HRQoL of elderly patients with hypertension and its influencing factors using EuroQol five-dimensional-three-level (EQ-5D-3L) in China.

Methods: Data were obtained from the 6th National Health Service Survey in Heilongjiang province from June to July 2018, with a stratified multistage random cluster sampling method. All eligible participants were interviewed using a standardized questionnaire, which included the EQ-5D-3L, socio-demographics characteristics, clinical and lifestyle characteristics. The mean EQ-5D index scores for the different subgroups were evaluated using ANOVA. A Tobit regression model was also employed to analyze the potential factors influencing HRQoL.

Results: A total of 705 elderly patients with hypertension were included in this study. The mean EQ-5D utility score was 0.79 [standard deviation (SD) = 0.23]. The proportion of participants reporting pain/discomfort problems was the highest (57.0%), while problems in self-care was the lowest (17.2%). Influencing factors of HRQoL for elderly patients with hypertension included gender, age, income, education level, physical activity, health examination and coexisting diseases. Specifically, the female gender, being above 80 years old, having a lower education and/or higher income, and the presence of coexisting diseases were associated with lower utility index. In contrast, regular physical activity and medical examination had a positive impact on the HRQoL of elderly hypertension patients.

Conclusion: Overall, elderly patients with hypertension in China have a lower HRQoL than the general population. To improve the HRQoL of elderly patients with hypertension, it is imperative that better public health education is provided to enhance the knowledge of hypertension, encourage the adoption of healthy habits such as regular physical activity and medical examination, and improve the management of coexisting diseases. More care should also be directed to males with hypertension who are above 80 years old.
The Aesthetics of Encounter: A Relational-Performative Design Approach to Human-Robot Interaction
Authors: Gemeinboeck Petra
Published: March 2021

This article lays out the framework for relational-performative aesthetics in human-robot interaction, comprising a theoretical lens and design approach for critical practice-based inquiries into embodied meaning-making in human-robot interaction. I explore the centrality of aesthetics as a practice of embodied meaning-making by drawing on my arts-led, performance-based approach to human-robot encounters, as well as other artistic practices. Understanding social agency and meaning as being enacted through the situated dynamics of the interaction, I bring into focus a process ofbodying-thinging;entangling and transforming subjects and objects in the encounter and rendering elastic boundaries in-between. Rather than serving to make the strange look more familiar, aesthetics here is about rendering the differences between humans and robots more relational. My notion of a relational-performative design approach—designing with bodying-thinging—proposes that we engage with human-robot encounters from the earliest stages of the robot design. This is where we begin to manifest boundaries that shape meaning-making and the potential for emergence, transformation, and connections arising from intra-bodily resonances (bodying-thinging). I argue that this relational-performative approach opens up new possibilities for how we design robots and how they socially participate in the encounter.
Roles of Parathyroid Hormone-Related Protein (PTHrP) and Its Receptor (PTHR1) in Normal and Tumor Tissues: Focus on Their Roles in Osteosarcoma
Authors: Al-Khan Awf A. , Al Balushi Noora R. , Richardson Samantha J. , Danks Janine A.
Published: March 2021

Osteosarcoma (OS) is the most common primary bone tumor and originates from bone forming mesenchymal cells and primarily affects children and adolescents. The 5-year survival rate for OS is 60 to 65%, with little improvement in prognosis during the last four decades. Studies have demonstrated the evolving roles of parathyroid hormone-related protein (PTHrP) and its receptor (PTHR1) in bone formation, bone remodeling, regulation of calcium transport from blood to milk, regulation of maternal calcium transport to the fetus and reabsorption of calcium in kidneys. These two molecules also play critical roles in the development, progression and metastasis of several tumors such as breast cancer, lung carcinoma, chondrosarcoma, squamous cell carcinoma, melanoma and OS. The protein expression of both PTHrP and PTHR1 have been demonstrated in OS, and their functions and proposed signaling pathways have been investigated yet their roles in OS have not been fully elucidated. This review aims to discuss the latest research with PTHrP and PTHR1 in OS tumorigenesis and possible mechanistic pathways.

This review is dedicated to Professor Michael Day who died in May 2020 and was a very generous collaborator.
Interferon-Inducible Transmembrane Protein 3-Containing Exosome as a New Carrier for the Cell-to-Cell Transmission of Anti-Brucella Activity
Authors: Yi Jihai , Wang Yueli , Zhang Huan , Deng Xiaoyu , Xi Jing , Li Honghuan , Yang Ningning , Ma Zhongchen , Wang Yong , Chen Chuangfu
Published: March 2021

Exosomes are small extracellular vesicles that are released from cells and that function in intercellular communication. Recently, interferon-inducible transmembrane protein 3 (IFITM3) has been identified as a highly effective anti-intracellular pathogen protein that can inhibit the invasion of a wide range of pathogenic microorganisms. However, whether Brucella infection induces secretion of exosomes and whether these exosomes contain IFITM3 protein remain unknown. Here, we focused on the immune function of extracellular IFITM3 protein in the process of Brucella infection. This study is the first to show that Brucella melitensis strain M5 (Brucella M5) can stimulate macrophages to secrete large amounts of exosomes. Most importantly, we identified exosomes from Brucella M5-infected cells that were rich in molecules of IFITM3, and these exosomes could transmit the IFITM3 from one cell to another, thereby effectively inhibiting the intracellular survival of Brucella. Moreover, immunization with exosomes carrying IFITM3 decreased mouse spleen tissue damage and spleen colony forming unit (CFU), leading to the establishment of an anti-Brucella state in mice. In conclusion, our findings provide new insights into the anti-Brucella mechanism of IFITM3-containg exosomes, thus providing a theoretical foundation for systematic elaboration of the mechanisms of Brucella infection and host immunity. The results provide new ideas for the development of candidate vaccines for Brucella.
On the Handling Qualities of Two Flying Wing Aircraft Configurations
Authors: Campos Luís M. B. C. , Marques Joaquim M. G.
Published: March 2021

The coupling of the longitudinal and lateral stability modes of an aeroplane is considered in two cases: (i) weak coupling, when the changes in the frequency and damping of the phugoid, short period, dutch roll, and helical modes are small, i.e., the square of the deviation is negligible compared to the square of the uncoupled value; (ii) strong coupling, when the coupled values may differ significantly from the uncoupled values. This allows a comparison of three values for the frequency and damping of each mode: (i) exact, i.e., fully coupled; (ii) with the approximation of weak coupling; (iii) with the assumption of decoupling. The comparison of these three values allows an assessment of the importance of coupling effects. The method is applied to two flying wing designs, concerning all modes in a total of eighteen flight conditions. It turns out that lateral-longitudinal coupling is small in all cases, and thus classical handling qualities criteria can be applied. The handling qualities are considered for all modes, namely the phugoid, short period, dutch roll, spiral, and roll modes. Additional focus is given to the pitch axis, considering the control anticipation parameter (CAP). The latter relates to the two kinds of manouever points, where damping vanishes, that are calculated for minimum speed, take-off, and initial and final cruise conditions. The conclusion compares two flying wings designs (the “long narrow” and “short wide” fuselage concepts) not only from the point of view of flight stability, but also from other viewpoints.
Genetic Parameters of Effort and Recovery in Sport Horses Assessed with Infrared Thermography
Authors: Bartolomé Ester , Perdomo-González Davinia Isabel , Sánchez-Guerrero María José , Valera Mercedes
Published: March 2021

The way a horse activates (effort phase-EP) and recovers (recovery phase-RP) during a sport event can affect its sport performance. The aim of this manuscript was to test horses’ adaptation to sport performance and its genetic basis, using eye temperature assessed with infrared thermography. EP and RP were measured in 495 Spanish Sport Horses, during a performance test, considering sex (2) and genetic lines (5) as fixed effects. The ranking position obtained on an official sport competition was also collected. Differences in variables due to genetic line and sex effects were found, showing that, regardless of the genetic line, stallions tended to recover better than mares after the sport test developed. High positive intra-class correlations (p < 0.001) were found between EP and RP for both fixed effects, so that the higher the EP, the higher the RP. However, for the ranking position, a low negative correlation (p < 0.01) was found, so that the higher the eye temperature increase, the better the position. Heritabilities showed medium–high values with a medium positive genetic correlation between them. Thus, breed origins and sex influence horses’ effort and recovery during sport performance, showing a genetic basis adequate for selection.
Characterization and Comparative Transcriptomic Analysis of Skeletal Muscle in Pekin Duck at Different Growth Stages Using RNA-Seq
Authors: Hu Zhigang , Cao Junting , Ge Liyan , Zhang Jianqin , Zhang Huilin , Liu Xiaolin
Published: March 2021

Skeletal muscle, accounting for approximately 50% of body weight, is the largest and most important tissue. In this study, the gene expression profiles and pathways in skeletal muscle of Pekin duck were investigated and compared at embryonic day 17, 21, and 27 and postnatally at 6 months of age. An average of 49,555,936 reads in each sample was obtained from the transcriptome libraries. Over 70.0% of alternative splicing (AS) in each sample was mainly alternative 5′ first exon (transcription start site)—the first exon splicing (TSS) and alternative 3′ last exon (transcription terminal site)—the last exon splicing (TTS), indicating that TSS and TTS were the most common AS event in Pekin ducks, and these AS events were closely related to the regulation of muscle development at different growth stages. The results provided a valuable genomic resource for selective breeding and functional studies of genes. A total of 299 novel genes with ≥2 exons were obtained. There were 294 to 2806 differentially expressed genes (DEGs) in each pairwise comparison of Pekin duck. Notably, 90 DEGs in breast muscle and 9 DEGs in leg muscle were co-expressed at all developmental points. DEGs were validated by qPCR analysis, which confirmed the tendency of the expression. DEGs related to muscle development were involved in biological processes such as “endodermal cell differentiation”, “muscle cell cellular homeostasis”, “skeletal muscle tissue growth” and “skeletal muscle cell differentiation”, and were involved in pathways such as oxidative phosphorylation, ECM-receptor (extracellular matrix receptor) interaction, focal adhesion, carbon metabolism, and biosynthesis of amino acids. Some DEGs, including MYL4, IGF2BP1, CSRP3, SPP1 and KLHL31, as well as LAMB2, LAMA2, ITGB1 and OPN, played crucial roles in muscle growth and development. This study provides valuable information about the expression profile of mRNAs and pathways from duck skeletal muscle at different growth stages, and further functional study of these mRNAs and pathways could provide new ideas for studying the molecular networks of growth and development in duck skeletal muscle.
Genomic Background and Phylogeny of cfiA-Positive Bacteroides fragilis Strains Resistant to Meropenem-EDTA
Authors: Valdezate Sylvia , Cobo Fernando , Monzón Sara , Medina-Pascual María J. , Zaballos Ángel , Cuesta Isabel , Pino-Rosa Silvia , Villalón Pilar
Published: March 2021

Background: Bacteroides fragilis shows high antimicrobial resistance (AMR) rates and possesses numerous AMR mechanisms. Its carbapenem-resistant strains (metallo-β-lactamase cfiA-positive) appear as an emergent, evolving clade. Methods: This work examines the genomes, taxonomy, and phylogenetic relationships with respect to other B. fragilis genomes of two B. fragilis strains (CNM20180471 and CNM20200206) resistant to meropenem+EDTA and other antimicrobial agents. Results: Both strains possessed cfiA genes (cfiA14b and the new cfiA28), along with other AMR mechanisms. The presence of other efflux-pump genes, mexAB/mexJK/mexXY-oprM, acrEF/mdtEF-tolC, and especially cusR, which reduces the entry of carbapenem via the repression of porin OprD, may be related to meropenem–EDTA resistance. None of the detected insertion sequences were located upstream of cfiA. The genomes of these and other B. fragilis strains that clustered together in phylogenetic analyses did not meet the condition of >95% average nucleotide/amino acid identity, or >70% in silico genome-to-genome hybridization similarity, to be deemed members of the same species, although <1% difference in the genomic G+C content was seen with respect to the reference genome B. fragilis NCTC 9343T. Conclusions: Carbapenem-resistant strains may be considered a distinct clonal entity, and their surveillance is recommended given the ease with which they appear to acquire AMR.
Garcinol Attenuates Lipoprotein(a)-Induced Oxidative Stress and Inflammatory Cytokine Production in Ventricular Cardiomyocyte through α7-Nicotinic Acetylcholine Receptor-Mediated Inhibition of the p38 MAPK and NF-κB Signaling Pathways
Authors: Chang Nen-Chung , Yeh Chi-Tai , Lin Yen-Kuang , Kuo Kuang-Tai , Fong Iat-Hang , Kounis Nicholas G. , Hu Patrick , Hung Ming-Yow
Published: March 2021

Garcinol, a nicotinic acetylcholine receptor (nAChR) antagonist, has recently been established as an anti-inflammation agent. However, the molecular mechanism by which garcinol suppresses inflammation in the context of acute myocardial infarction (AMI) remains unclear. Hypothesis: We hypothesized that the administration of physiological doses of garcinol in mice with isoproterenol-induced AMI decreased the effect of lipoprotein(a) (Lp(a))-induced inflammation both in vivo and in vitro via the α7-nAChRs mediated p38 mitogen-activated protein kinase (MAPK)/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) signaling pathway. We analyzed altered reactive oxygen species (ROS) generation, the production of superoxide by mitochondria, cytokine expression patterns, and the role of the p38 MAPK/NF-κB signaling pathway after Lp(a)-stimulated human ventricular cardiomyocyte AC16 cells were treated with increasing doses of garcinol. C-reactive protein (CRP), interleukin (IL)-1β, IL-6, or tumor necrosis factor (TNF)-α production were detected by enzyme-linked immunosorbent assay. The Cell Counting Kit-8 assay was used to evaluate drug cytotoxicity. Western blots and confocal fluorescence microscopy were used to determine altered expression patterns of inflammatory biomarkers. We also examined whether the therapeutic effect of garcinol in AMI was mediated in part by α7-nAChR. Lp(a)-induced inflammatory cardiomyocytes had increased expression of membrane-bound α7-nAChRs in vitro and in vivo. Low-dose garcinol did not affect cardiomyocyte viability but significantly reduced mitochondrial ROS, CRP, IL-1β, IL-6, and TNF-α production in Lp(a)-stimulated cardiomyocytes (p < 0.05). The Lp(a)-induced phosphorylation of p38 MAPKs, CamKII, and NFκB, as well as NFκB-p65 nuclear translocation, was also suppressed (p < 0.05) by garcinol, while the inhibition of p38 MAPK by the inhibitor SB203580 decreased the phosphorylation of extracellular signal-regulated kinase (ERK) and p38 MAPK. Garcinol protected cardiomyocytes by inhibiting apoptosis and inflammation in mice with AMI. Furthermore, garcinol also enhanced the expression of microRNA-205 that suppressed the α7-nAChR-induced p38 MAPK/NF-κB signaling pathway. Garcinol suppresses Lp(a)-induced oxidative stress and inflammatory cytokines by α7-nAChR-mediated inhibition of p38 MAPK/NF-κB signaling in cardiomyocyte AC16 cells and isoproterenol-induced AMI mice.
What Did We Accomplish in Fighting Radical Species in Human Health?
Authors: Skouta Rachid
Published: March 2021

Maintaining the physiological level of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the body is highly important in the fight against radical species in the context of human health [...]
On the Use of Structured Prior Models for Bayesian Compressive Sensing of Modulated Signals
Authors: Marnissi Yosra , Hawwari Yasmine , Assoumane Amadou , Abboud Dany , El-Badaoui Mohamed
Published: March 2021

The compressive sensing (CS) of mechanical signals is an emerging research topic for remote condition monitoring. The signals generated by machines are mostly periodic due to the rotating nature of its components. Often, these vibrations witness strong interactions among two or multiple rotating sources, leading to modulation phenomena. This paper is specifically concerned with the CS of this particular class of signals using a Bayesian approach. The main contribution of this paper is to consider the particular spectral structure of these signals through two families of hierarchical models. The first one adopts a block-sparse model that jointly estimates the sparse coefficients at identical or symmetrical positions around the carrier frequencies. The second is a spike-and-slab model where the spike component takes into account the symmetrical properties of the support of non-zero-coefficients in the spectrum. The resulting posterior distribution is approximated using a Gibbs sampler. Simulations show that considering the structure in the prior model yields better noise shrinkage and better reconstruction of small side-bands. Application to condition monitoring of a gearbox through CS of vibration signals highlights the good performance of the proposed models in reconstructing the signal, offering an accurate fault detection with relatively high compression rate.
Rapid Nondestructive Postharvest Potato Freshness and Cultivar Discrimination Assessment
Authors: Kasampalis Dimitrios S. , Tsouvaltzis Pavlos , Ntouros Konstantinos , Gertsis Athanasios , Moshou Dimitrios , Siomos Anastasios S.
Published: March 2021

Background: Quality and safety of potato is both cultivar and postharvest management dependent. The precise assessment of freshness and cultivar are complex tasks requiring time-consuming, expensive, and destructive techniques. Method: Potatoes from three commercial cultivars were stored for 5 months at 5 °C. Color and chlorophyll fluorescence were recorded, Red-Green-Blue (R-G-B), Red-Green-Near infrared (R-G-NIR) and Red-Blue-Near infrared (R-B-NIR) digital images, as well as hyperspectral images were acquired both on the external periderm of the tuber and in the inner flesh part. Partial least square regression (PLSR) and discriminant analysis, combined with feature selection techniques were implemented, in order to assess the potato freshness and to classify them into the respective genotypes. Results: The PLSR analysis of visible/near infrared (Vis/NIR) spectra reflectance most reliably predicted potato freshness, with a cross-validated regression coefficient equal to 0.981 and 0.947, as determined by external or internal measurements, respectively. Variance inflation factor, variable importance scores, and genetic algorithms identified specific wavelength regions that mostly affected the accuracy of the model in terms of strongest regression and lowest collinearity and root mean cross validation error. Conclusions: Vis/NIR spectra reflectance data from the skin of the potato tubers may be reliably used in the assessment of postharvest storage life, as well as in the cultivar discrimination process.
Assessment of Periodontium Temperature Changes under Orthodontic Force by Using Objective and Automatic Classifier
Authors: Machoy Monika , Szyszka-Sommerfeld Liliana , Koprowski Robert , Wawrzyk Anna , Woźniak Krzysztof , Wilczyński Sławomir
Published: March 2021

Background: Orthodontic elastics are used in orthodontic treatment with fixed braces. The effect of class I elastics on changing gingiva temperature as a periodontal component was investigated. Methods: To evaluate the temperature changes, objective and automatic classifiers were used to determine the sensitivity and specificity of the measurement. Results: Before putting on the elastics, the average gingival temperature of all 120 patients was 34.72 ± 0.7548 °C. Putting on the elastics for 10 min slightly increased the temperature to 34.81 ± 0.5938 °C; however, this is not a statistically significant change (p > 0.05). Conclusion: It is concluded that putting an elastic band on does not significantly affect the gingiva temperature change. The use of class I elastics in orthodontic treatment in patients with healthy periodontium does not significantly change the periodontal temperature, which indirectly proves the production of safe orthodontic forces that can be used in the clinic. The use of artificial intelligence in the assessment of the temperature of the gingiva makes it possible to exclude factors that may disturb the objective thermographic analysis.
Development of 3D-Printed MWCNTs/AC/BNNTs Ternary Composite Electrode Material with High-Capacitance Performance
Authors: Alam Asrar , Saeed Ghuzanfar , Hong Seong Min , Lim Sooman
Published: March 2021

Activated carbon (AC) and multiwalled carbon nanotubes (MWCNTs) have been extensively investigated in recent decades as electrical double-layer capacitor (EDLC) electrode materials for supercapacitors, owing to their superior capacitive properties and cycling stability performance. However, in the modern electronics industry, ternary electrode materials have been designed to develop high-performance and efficient energy storage devices. EDLC-based ternary materials are of great importance, where all the present components participate both individually and as a multicomponent electrode system to promote high-electrochemical performance electrode materials. In this study, we have incorporated an optimized content of boron nitride nanotube (BNNT) powder into a binary material composed of AC and MWCNTs to enhance their electrochemical performance using a pneumatic printer. The printed MWCNTs/AC/BNNTs ternary composite electrode material has shown a maximum specific capacitance of 262 F g−1 at a minimum current density of 1 A g−1, with a capacitance retention of 49.61% at a maximum current density of 10 A g−1. These results demonstrate that the printable MWCNTs/AC/BNNTs ternary composite electrode material is a potential candidate for the development of high-performance supercapacitors.
Differences of Mechanical Parameters and Rockburst Tendency Indices between Coal and Non-Coal Rocks and Modified Rockburst Tendency Classification Criteria for Non-Coal Rocks
Authors: Du Kun , Sun Yu , Yang Songge , Lv Shizhan , Wang Shaofeng
Published: March 2021

Rockbursts represent hazardous dynamic disasters for underground coal mines and other underground rock engineering projects. Some bursting liability indices are put forward and applied to identify the likelihood of rock burst occurrence. The classification criteria of the bursting liability indices are proved to be reasonable for coals, but they are still immature for non-coal rocks. Thus, it is uncertain that it is reasonable to use the classification criteria of coal for evaluating the bursting liability of non-coal rocks. Hence, in this study, a large amount of data, such as the basic mechanical parameters, i.e., Poisson’s ratio μ, elastic modulus E, uniaxial compressive strength σc, and uniaxial tensile strength σt, and the bursting liability indices, i.e., elastic strain energy index WET, bursting energy index Wcf, dynamic fracture duration time DT, and brittleness index B, of different coals and non-coal rocks were collected in China. Then, the differences of mechanical parameters and rockburst tendency indices between coal and non-coal rocks were studied systematically, and apart from the Poisson’s ratio μ, the other three basic mechanical parameters of coal and non-coal rocks have great differences in data distribution and concentration scope, which proved that the non-coal rocks cannot share the same index system and classification criteria of coals. In addition, the evaluation results of a single index for rock bursting liability of rocks were directly compared in pairs, and the inconsistency rate for coals is about 42–68%. It is necessary to build a comprehensive evaluation method to evaluate the bursting liability of rocks. At last, the modified rockburst tendency classification criteria for non-coal rocks were put forward. It is reasonable to use the classification criteria of the WET and Wcf to classify the bursting liability of non-coal rocks, while it is unreasonable to use that of the DT and σc. It has been concluded that the index B are more suitable for non-coal rocks, and a new index, named strength decrease rate (SDR), was proposed to determine the bursting liability, which is the ratio of uniaxial compressive strength σc to duration of dynamic fracture DT.
Automation of a Thin-Layer Load-Bearing Structure Design on the Example of High Altitude Long Endurance Unmanned Aerial Vehicle (HALE UAV)
Authors: Skarka Wojciech , Jałowiecki Andrzej
Published: March 2021

In the aerospace industry, thin-layer composites are increasingly used for load-bearing structures. When designing such composite structures, particular attention must be paid to the development of an appropriate geometric form of the structure to increase the structure’s load capacity and reduce the possibility of a loss of stability and harmful aeroelastic phenomena. For this reason, the use of knowledge-based engineering support methods is complicated. Software was developed to propose and quickly evaluate a thin-layer load-bearing structure using generative modeling methods to facilitate development of the initial concept of an aerospace load-bearing structure. Finite Element Method (FEM) analysis verifies and improves such structures. The most important contributions of the paper are a methodology for automating the design of ultralight and highly flexible aircraft structures with the use of generative modelling, proposing and verifying the form of generative models for selected fragments of the structure, especially wings, and integration of the use of generative models for iterative improvement of structures using low- and middle-fidelity methods of numerical verification.
Analysis and Optimization of Driveline Bushing for Lateral Ride Vibration under Shock Excitation
Authors: Guo Peng , Li Jinlu , Lin Zefeng , Lin Jiewei
Published: March 2021

Ride comfort is increasingly important for automobile companies due to the increasing concern of the demands of customers. Response to shock at low speed, such as single or consecutive pulse excitations from humps, are one of the greatest assessing indices of vehicle ride related to the ride comfort. This paper aims to study the effect of driveline bushing on ride vibration when the vehicle experiences shock excitation and to improve the ride quality by optimizing the bushing parameters. A vehicle level multibody dynamic model with a differential-subframe subsystem is developed and calibrated against field test data. The sensitivities of the bushing stiffness and damping coefficients are analyzed and the most influential bushing parameters on the seat rail vibration are identified. The relationship between the bushing parameters and the ride vibration is developed by a 5-level response surface design. The fitted response functions are validated and adopted as the optimization objectives. The optimized results, including the acceleration, the running r.m.s. acceleration, the jerk, the running r.m.s. jerk, the VDV and the comfort, are compared with those of the baseline vehicle. Results show that the optimized bushings significantly decrease the vibration at the driver and the rear passenger seats by approximately 50% in the lateral direction. A considerable improvement has been achieved in ride comfort that the weighted vibration at seats is reduced to a level below the median perception threshold of human being in the lateral direction.
Adsorption of Cd2+ Ions from Aqueous Solution Using Biomasses of Theobroma cacao, Zea mays, Manihot esculenta, Dioscorea rotundata and Elaeis guineensis
Authors: Villabona-Ortíz Ángel , Tejada-Tovar Candelaria , Gonzalez-Delgado Ángel Darío
Published: March 2021

In this work, the mechanisms of cadmium (Cd2+) adsorption on residual biomasses from husks of yam (Dioscorea rotundata), cassava (Manihor esculenta), cocoa (Theobroma cacao), corn (Zea mays) and oil palm bagasse (Elaeis guineensis) were studied in order to evaluate the effect of temperature, adsorbent dose and particle size in a batch system. Isotherms and adsorption kinetics were determined and adjusted to different models. The biomaterials were characterized using the techniques of Scanning Electron Microscopy (SEM) and Energy-Dispersive X-ray Spectroscopy (EDS). Results reveal that the possible mechanisms of Cd2+ adsorption in bioadsorbents were ion exchange and complexation with -COOH and -OH groups. From the experimentation, it was found that best conditions were presented at 55 °C, particle size 0.5 mm and 0.03 g adsorbent. The following biomass performance was obtained in terms of adsorption capacities: cocoa husk (CH) > corn cob residues (CCR) > cassava peel (CP) > palm bagasse (OPB) > yam peel (YP), according to the Langmuir and Dubinin- Radushkevich (D-R) models. The equilibrium of Cd2+ adsorption over YP and OPB was well described by Langmuir’s isothermal model, while for CH, CCR and CP the model that best fit experimental data was Freundlich’s model. The results of D-R model suggested that the process is controlled by physisorption mechanism with strong interactions among active sites and Cd2+ ions. The kinetics for all systems studied fit the pseudo-second order model. The values of the thermodynamic parameters established that cadmium removal is of endothermic nature and not spontaneous using YP and CP, and exothermic, spontaneous and irreversible when using OPB, CH and CCR. The results suggest the use of YP, OPB, CH, CP and CCR residues for the removal of aqueous Cd2+.
Annual NO2 as a Predictor of Hourly NO2 Variability: Do Defra UK’s Heuristics Make Sense?
Authors: Mills Ashley , Peckham Stephen
Published: March 2021

Background: In the UK an hourly objective exists for NO2 concentrations and assessment against this objective is required for various administrative purposes. The vast majority of NO2 measurement in the UK is non-hourly however. Thus, Defra guidance provides a heuristic to estimate hourly objective exceedance likelihood from an annual average. Methods: We examine the performance of this heuristic using a Europe wide dataset containing over 20,000 site-years of data, and perform a sensitivity test to account for data uncertainty. Results: The heuristic misses 64% of sites that break the hourly objective. The heuristic is neither a necessary nor sufficient condition for predicting hourly objective breaches. The sensitivity test reveals that the heuristic is input-fragile. Conclusions: The heuristic performs poorly, is weakly coupled to medical evidence, and work is needed to develop new short term exposure limits for NO2.
The Comparative Effects of Mesenchymal Stem Cell Transplantation Therapy for Spinal Cord Injury in Humans and Animal Models: A Systematic Review and Meta-Analysis
Authors: Johnson Louis D. V. , Pickard Mark R. , Johnson William E. B.
Published: March 2021

Animal models have been used in preclinical research to examine potential new treatments for spinal cord injury (SCI), including mesenchymal stem cell (MSC) transplantation. MSC transplants have been studied in early human trials. Whether the animal models represent the human studies is unclear. This systematic review and meta-analysis has examined the effects of MSC transplants in human and animal studies. Following searches of PubMed, Clinical Trials and the Cochrane Library, published papers were screened, and data were extracted and analysed. MSC transplantation was associated with significantly improved motor and sensory function in humans, and significantly increased locomotor function in animals. However, there are discrepancies between the studies of human participants and animal models, including timing of MSC transplant post-injury and source of MSCs. Additionally, difficulty in the comparison of functional outcome measures across species limits the predictive nature of the animal research. These findings have been summarised, and recommendations for further research are discussed to better enable the translation of animal models to MSC-based human clinical therapy.
Oligonucleotide-Based Therapies for Renal Diseases
Authors: Cartón-García Fernando , Saande Cassondra Jeanette , Meraviglia-Crivelli Daniel , Aldabe Rafael , Pastor Fernando
Published: March 2021

The global burden of chronic kidney disease (CKD) is increasing every year and represents a great cost for public healthcare systems, as the majority of these diseases are progressive. Therefore, there is an urgent need to develop new therapies. Oligonucleotide-based drugs are emerging as novel and promising alternatives to traditional drugs. Their expansion corresponds with new knowledge regarding the molecular basis underlying CKD, and they are already showing encouraging preclinical results, with two candidates being evaluated in clinical trials. However, despite recent technological advances, efficient kidney delivery remains challenging, and the presence of off-targets and side-effects precludes development and translation to the clinic. In this review, we provide an overview of the various oligotherapeutic strategies used preclinically, emphasizing the most recent findings in the field, together with the different strategies employed to achieve proper kidney delivery. The use of different nanotechnological platforms, including nanocarriers, nanoparticles, viral vectors or aptamers, and their potential for the development of more specific and effective treatments is also outlined.
Deciphering the Role of Heme Oxygenase-1 (HO-1) Expressing Macrophages in Renal Ischemia-Reperfusion Injury
Authors: Rossi Maxime , Korpak Kéziah , Doerfler Arnaud , Zouaoui Boudjeltia Karim
Published: March 2021

Ischemia-reperfusion injury (IRI) is a leading cause of acute kidney injury (AKI), which contributes to the development of chronic kidney disease (CKD). Renal IRI combines major events, including a strong inflammatory immune response leading to extensive cell injuries, necrosis and late interstitial fibrosis. Macrophages act as key players in IRI-induced AKI by polarizing into proinflammatory M1 and anti-inflammatory M2 phenotypes. Compelling evidence exists that the stress-responsive enzyme, heme oxygenase-1 (HO-1), mediates protection against renal IRI and modulates macrophage polarization by enhancing a M2 subset. Hereafter, we review the dual effect of macrophages in the pathogenesis of IRI-induced AKI and discuss the critical role of HO-1 expressing macrophages.
68Ga-DOTATOC PET/CT Follow Up after Single or Hypofractionated Gamma Knife ICON Radiosurgery for Meningioma Patients
Authors: Barone Fabio , Inserra Francesco , Scalia Gianluca , Ippolito Massimo , Cosentino Sebastiano , Crea Antonio , Sabini Maria Gabriella , Valastro Lucia , Patti Iolanda Valeria , Mele Stefania , Acquaviva Grazia , Tocco Alessandra , Tamburo Maria , Graziano Francesca , Tomasi Ottavio S. , Maugeri Rosario , Iacopino Gerardo , Cicero Salvatore , Strigari Lidia , Umana Giuseppe Emmanuele
Published: March 2021

68Ga-DOTATOC represents a useful tool in tumor contouring for radiosurgery planning. We present a case series of patients affected by meningiomas on who we performed 68Ga-DOTATOC positron emission tomography (PET)/CT pre-operatively, a subgroup of which also underwent a post-operative 68Ga-DOTATOC PET/CT to evaluate the standardized uptake value (SUV) modification after Gamma Knife ICON treatment in single or hypofractionated fractions. Twenty patients were enrolled/included in this study: ten females and ten males. The median age was 52 years (range 33–80). The median tumor diameter was 3.68 cm (range 0.12–22.26 cm), and the median pre-radiotherapy maximum SUV value was 11 (range 2.3–92). The average of the relative percentage changes between SUVs at baseline and follow up was −6%, ranging from −41% to 56%. The SUV was reduced in seven out of 12 patients (58%), stable in two out of 12 (17%), and increased in three out of 12 (25%), suggesting a biological response of the tumor to the Gamma Knife treatment in most of the cases. 68Ga-DOTATOC-PET represents a valuable tool in assessing the meningioma diagnosis for primary radiosurgery; it is also promising for follow-up assessment.
Reply to Comment on Roelofs, K.A.; et al. “Detecting Progression of Melanocytic Choroidal Tumours by Sequential Imaging: Is Ultrasonography Necessary?” Cancers 2020, 12, 1856
Authors: Roelofs Kelsey A. , O’Day Roderick , Harby Lamis Al , Hay Gordon , Arora Amit K. , Sagoo Mandeep S. , Damato Bertil
Published: March 2021

We thank Capasso et al [...]