bluuebunny/crossref_metadata_2025 huggingface dataset:
A Quantitative Meta-Analysis and Qualitative Meta-Synthesis of Aged Care Residents’ Experiences of Autonomy, Being Controlled, and Optimal Functioning
Authors: Bradshaw Emma L , Anderson Joel R , Banday Ma A J , Basarkod Geetanjali , Daliri-Ngametua Rafaan , Ferber Kelly A , Henry Dylan , Ryan Richard M
Published: October 2023

Background and Objectives

The poor mental health of adults living in aged care needs addressing. Improvements to nutrition and exercise are important, but mental health requires a psychological approach. Self-determination theory finds that autonomy is essential to wellbeing while experiences of being controlled undermine it. A review of existing quantitative data could underscore the importance of autonomy in aged care, and a review of the qualitative literature could inform ways to promote autonomy and avoid control. Testing these possibilities was the objective of this research.

Research Design and Methods

We conducted a mixed-methods systematic review of studies investigating autonomy, control, and indices of optimal functioning in aged care settings. The search identified 30 eligible reports (19 quantitative, 11 qualitative), including 141 quantitative effect sizes, 84 qualitative data items, and N = 2,668. Quantitative effects were pooled using three-level meta-analytic structural equation models, and the qualitative data were meta-synthesized using a grounded theory approach.

Results

As predicted, the meta-analysis showed a positive effect of aged care residents’ autonomy and their wellness, r = 0.33 [95% CI: 0.27, 0.39], and a negative effect of control, r = −0.16 [95% CI: −0.27, −0.06]. The meta-synthesis revealed seven primary and three sub-themes describing the nuanced ways autonomy, control, and help seeking are manifest in residential aged care settings.

Discussion and Implications

The results suggest that autonomy should be supported, and unnecessary external control should be minimized in residential aged care, and we discuss ways the sector could strive for both aims.
Crohn’s Disease of the Ileoanal Pouch: A High Rate of Potential Overdiagnoses
Authors: Reijntjes Maud , de Jong Djuna , Wessels Elise , Goetgebuer Rogier , Bemelman Willem , Ponsioen Cyriel , D’Haens Geert , Hompes Roel , Buskens Christianne , Duijvestein Marjolijn
Published: October 2023

Background

Approximately 1 in 10 patients with an ileal pouch–anal anastomosis is diagnosed with Crohn’s disease of the pouch (CDP). However, this diagnosis may be established inappropriately, as alternative underlying causes necessitating an alternative treatment approach, such as long-term surgical sequelae, may mimic CDP. In this study, we aimed to identify patients diagnosed with and treated for CDP with a (concurrent) alternative diagnosis.

Methods

Ulcerative colitis and inflammatory bowel disease unclassified patients who underwent ileal pouch–anal anastomosis surgery in a tertiary center between 1990 and 2017 were retrospectively reviewed. Patients with a postoperative diagnosis of CDP for which medical treatment was initiated were identified. Presence of pouchitis, prepouch ileitis, stricture, and fistulas was assessed and histopathological reports were evaluated. Thereafter, cross-sectional images of the pouch in CDP patients were re-evaluated to identify potential long-term surgical sequelae (ie, chronic presacral sinus or perianastomotic fistulas).

Results

After a median postoperative follow-up of 6.2 (interquartile range, 2.3-13.5) years, 47 (10%) of 481 patients were diagnosed with CDP. CDP patients had pouchitis (n = 38 [81%]), prepouch ileitis (n = 34 [74%]), strictures (n = 17 [36%]), fistulas (n = 15 [32%]), or a combination. Multiple granulomas were found in 1 pouch resection specimen. Re-evaluation of 40 (85%) patients who underwent magnetic resonance imaging revealed presence of long-term surgical sequelae in 17 (43%) patients. Six (15%) patients demonstrated isolated nonanastomotic fistulas.

Conclusion

Re-evaluation of cross-sectional imaging of the pouch revealed that potential alternative causes were found in nearly half of CDP patients. Cross-sectional imaging is therefore recommended early in the diagnostic pathway to exclude an alternative diagnosis.
High Rates of Seroprotection and Seroconversion to Vaccine-Preventable Infections in the Early Post–Autologous Stem Cell Transplant Period
Authors: Hall Victoria G , Saunders Natalie R , Klimevski Emily , Tennakoon Gayani S , Khot Amit , Harrison Simon , Worth Leon J , Yong Michelle K , Slavin Monica A , Teh Benjamin W
Published: October 2023

In patients early post–autologous stem cell transplant, seroprotection rates were high for Hemophilus influenzae type B and tetanus toxoid (70%–90%) but lower for Streptococcus pneumoniae (30%–50%) including after revaccination. There were high rates of seropositivity (67%–86%) to measles, mumps, and rubella and varicella zoster virus. Durability of protection requires assessment.
Zinc finger transcription factor MtZPT2-2 negatively regulates salt tolerance in Medicago truncatula
Authors: Huang Risheng , Jiang Shouzhen , Dai Mengtong , Shi Haifan , Zhu Haifeng , Guo Zhenfei
Published: October 2023

Zinc finger proteins (ZFPs) are transcription factors involved in multiple cellular functions. We identified a C2H2 type ZFP (MtZPT2-2) in Medicago truncatula and demonstrated that it localizes to the nucleus and inhibits the transcription of 2 genes encoding high-affinity potassium transporters (MtHKT1;1 and MtHKT1;2). MtZPT2-2 transcripts were detected in stem, leaf, flower, seeds and roots, with the highest level in the xylem and phloem of roots and stems. MtZPT2-2 transcription in leaves was reduced after salt stress. Compared with the wild-type (WT), transgenic lines overexpressing MtZPT2-2 had decreased salt tolerance, while MtZPT2-2–knockout mutants showed increased salt tolerance. MtHKT1;1 and MtHKT1;2 transcripts and Na+ accumulation in shoots and roots, as well as in the xylem of all genotypes of plants, were increased after salt treatment, with higher levels of MtHKT1;1 and MtHKT1;2 transcripts and Na+ accumulation in MtZPT2-2–knockout mutants and lower levels in MtZPT2-2–overexpressing lines compared with the WT. K+ levels showed no significant difference among plant genotypes under salt stress. Moreover, MtZPT2-2 was demonstrated to bind with the promoter of MtHKT1;1 and MtHKT1;2 to inhibit their expression. Antioxidant enzyme activities and the gene transcript levels were accordingly upregulated in response to salt, with higher levels in MtZPT2-2–knockout mutants and lower levels in MtZPT2-2–overexpressing lines compared with WT. The results suggest that MtZPT2-2 regulates salt tolerance negatively through downregulating MtHKT1;1 and MtHKT1;2 expression directly to reduce Na+ unloading from the xylem and regulates antioxidant defense indirectly.
Xylan clustering on the pollen surface is required for exine patterning
Authors: Xu Rui , Liu Zhuolin , Wang Xiaohong , Zhou Yihua , Zhang Baocai
Published: October 2023

Xylan is a crosslinking polymer that plays an important role in the assembly of heterogeneous cell wall structures in plants. The pollen wall, a specialized cell wall matrix, exhibits diverse sculpted patterns that serve to protect male gametophytes and facilitate pollination during plant reproduction. However, whether xylan is precisely anchored into clusters and its influence on pollen wall patterning remain unclear. Here, we report xylan clustering on the mature pollen surface in different plant species that is indispensable for the formation of sculpted exine patterns in dicot and monocot plants. Chemical composition analyses revealed that xylan is generally present at low abundance in the mature pollen of flowering plants and shows plentiful variations in terms of substitutions and modifications. Consistent with the expression profiles of their encoding genes, genetic characterization revealed IRREGULAR XYLEM10-LIKE (IRX10L) and its homologous proteins in the GT47 family of glycosyltransferases as key players in the formation of these xylan micro-/nano-compartments on the pollen surface in Arabidopsis (Arabidopsis thaliana) and rice (Oryza sativa). A deficiency in xylan biosynthesis abolished exine patterning on pollen and compromised male fertility. Therefore, our study outlines a mechanism of exine patterning and provides a tool for manipulating male fertility in crop breeding.
Benchmarking TriadAb using targets from the second antibody modeling assessment
Authors: Lee Frederick S , Anderson Amos G , Olafson Barry D
Published: October 2023

Computational modeling and design of antibodies has become an integral part of today’s research and development in antibody therapeutics. Here we describe the Triad Antibody Homology Modeling (TriadAb) package, a functionality of the Triad protein design platform that predicts the structure of any heavy and light chain sequences of an antibody Fv domain using template-based modeling. To gauge the performance of TriadAb, we benchmarked against the results of the Second Antibody Modeling Assessment (AMA-II). On average, TriadAb produced main-chain carbonyl root-mean-square deviations between models and experimentally determined structures at 1.10 Å, 1.45 Å, 1.41 Å, 3.04 Å, 1.47 Å, 1.27 Å, 1.63 Å in the framework and the six complementarity-determining regions (H1, H2, H3, L1, L2, L3), respectively. The inaugural results are comparable to those reported in AMA-II, corroborating with our internal bench-based experiences that models generated using TriadAb are sufficiently accurate and useful for antibody engineering using the sequence design capabilities provided by Triad.
Serum alarmins and the risk of incident interstitial lung disease in rheumatoid arthritis
Authors: Poole Jill A , England Bryant R , Sayles Harlan , Johnson Tate M , Duryee Michael J , Hunter Carlos D , Baker Joshua F , Kerr Gail S , Kunkel Gary , Cannon Grant W , Sauer Brian C , Wysham Katherine D , Joseph Amy M , Wallace Beth I , Thiele Geoffrey M , Mikuls Ted R
Published: October 2023

Objectives

To quantify associations of serum alarmins with risk of rheumatoid arthritis-associated interstitial lung disease (RA-ILD).

Methods

Using serum collected at enrolment, three alarmins (IL-33, thymic stromal lymphopoietin [TSLP] and IL-25) were measured in a multicentre prospective RA cohort. ILD was classified using systematic medical record review. Cross-sectional associations of log-transformed (IL-33, TSLP) or quartile (IL-25) values with RA-ILD at enrolment (prevalent RA-ILD) were examined using logistic regression, while associations with incident RA-ILD developing after enrolment were examined using Cox proportional hazards. Covariates in multivariate models included age, sex, race, smoking status, RA disease activity score and anti-cyclic citrullinated antibody positivity.

Results

Of 2835 study participants, 115 participants (4.1%) had prevalent RA-ILD at baseline and an additional 146 (5.1%) developed incident ILD. There were no associations between serum alarmin concentrations and prevalent ILD in unadjusted or adjusted logistic regression models. In contrast, there was a significant inverse association between IL-33 concentration and the risk of developing incident RA-ILD in unadjusted (hazard ratio [HR] 0.73 per log-fold increase; 95% CI: 0.57, 0.95; P = 0.018) and adjusted (HR 0.77; 95% CI: 0.59, 1.00; P = 0.047) models. No significant associations of TSLP or IL-25 with incident ILD were observed.

Conclusion

In this study, we observed a significant inverse association between serum IL-33 concentration and the risk of developing incident RA-ILD, but no associations with prevalent ILD. Additional investigation is required to better understand the mechanisms driving this relationship and how serum alarmin IL-33 assessment might contribute to clinical risk stratification in patients with RA.
Radial Nerve Palsy Due to Blood Pressure Cuff Compression after Prolonged Combined Plastic Surgery
Authors: Netshiongolwe Thendo T.
Published: October 2023

As plastic surgery procedures become safer and more popular, the number of patients undergoing cosmetic surgery will rise. A recent trend in plastic surgery has been a rise in combining multiple procedures in a single setting. Such an approach has the advantage of lower surgical cost to the patient and affords the patient a reduced downtime from work. Although the complication profile of patients undergoing plastic surgery is well documented, combining procedures prolongs operation time, which has been associated with a significant increase in the risk of complications. Our case report describes a patient who presented with a wrist drop and paraesthesia in the radial nerve distribution 1 day postoperatively after prolonged combined breast reduction and abdominoplasty procedures. The patient was diagnosed with radial nerve neuropraxia through electromyography. She was reassured, treated by an occupational therapist and showed complete recovery within 3 months. Surgeons offering combined procedures for plastic surgery should be aware of the risk of nerve injury associated with prolonged blood pressure cuff monitoring and take precautionary measures to prevent this risk.
Effect of spiritual care on the quality of life in patients who underwent intracranial hemorrhage surgery: a randomized controlled trial
Authors: Goli Rasoul , Faraji Navid , Maroofi Himan , Hassanpour Amireh
Published: October 2023

Introduction:

One of the most important complications of stroke after intracranial hemorrhage surgery is impaired quality of life. This study was conducted to determine the impact of spiritual care on the quality of life of stroke patients.

Methods:

This single-blind clinical trial with a pretest and posttest design was conducted on 100 stroke patients. Participants were recruited and randomly assigned to a control group and an intervention group. The Stroke-Specific Quality of Life Scale (SS -QoL) was used to assess the quality of life of stroke patients. The intervention group received four sessions of spiritual care.

Results:

The independent t test showed no significant difference between the 2 groups in the mean quality of life score (t=−0.120,P=0.281) and its dimensions before the intervention. However, after the intervention, the results showed a significant difference between the two groups in terms of the mean quality of life score (t=1.984,P<0.001) and its dimensions. In addition, the results of the paired t test showed that in the intervention group, the mean score of quality of life (t=5.161,P<0.001) and its dimensions were significantly different before and after the intervention. Furthermore, the results showed that before and after the intervention in the control group, the mean score of quality of life (t=1.109,P=0.614) and its dimensions were not significantly different.

Conclusion:

Based on our results, we strongly recommend the use of spiritual care as a holistic care and complementary method to improve the symptoms and quality of life of stroke patients.
Safety and feasibility of intravascular ultrasound-guided robotic percutaneous coronary intervention
Authors: Kimura Takumi , Koeda Yorihiko , Ishida Masaru , Numahata Wataru , Yamaya Shohei , Kikuchi Sayaka , Ishisone Takenori , Goto Iwao , Itoh Tomonori , Morino Yoshihiro
Published: October 2023

Objective

Previous studies have demonstrated the benefit of intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) for preventing longitudinal geographic miss (LGM). However, it is yet unclear whether IVUS guidance is useful for robotic-PCI (robotic-assisted perctaneous coronary intervention [R-PCI]).

Methods

A total of 58 consecutive patients with stable angina who underwent IVUS-guided R-PCI were enrolled. The stent landing position was angiographically marked using a balloon marker before stenting, followed by measurements of the expected stent length using balloon pullback. Subsequently, prestenting IVUS was performed to determine stent landing. All pre-PCI IVUS images were assessed for lesion length and percent plaque volume (%PV) using both IVUS and angiographic marking. LGM was defined as a residual %PV >50% at either the distal or proximal stent edge, any stent edge dissection, or additional stent deployment immediately after stenting.

Results

The included patients had an average age of 67.1 ± 10.1 years. IVUS guidance had significantly longer lesion lengths compared with angiographic marking. Based on IVUS-guided stent deployment, nine cases exhibited LGM immediately after stenting. IVUS-marked landing points had a significantly smaller %PV and significantly larger lumen area compared with those for angiography.

Conclusion

IVUS-guided R-PCI was well-tolerated and may be better at preventing LGM compared with angiography-guided R-PCI.
Ultrasound imaging of the phrenic nerve at the scalene muscle level
Authors: Bedewi Mohamed Abdelmohsen , Habib Yomna S. , Sifey Ayman A. , Kotb Mamdouh Ali , Almalki Daifallah Mohammed , AlAseeri Ali Abdullah , Alhariqi Bader A. , Sandougah Kholoud J. , Alfaifi Tariq , Marsico Salvatore , Awad Mariam EM , Soliman Steven B.
Published: October 2023

The aim of this study is to utilize ultrasound to evaluate the normal cross-sectional area (CSA) of the phrenic nerve (PN), at the level of the anterior scalene muscle. The study included 62 PNs in 31 healthy subjects (13 men, 18 women); mean age, 36.6 years; mean height, 161.1 cm; mean weight, 69.6 kg; and mean body mass index 25.8 kg/m2. High-resolution ultrasound images of the bilateral PNs were obtained by a radiologist with 15 years of experience in neuromusculoskeletal ultrasound. Three separate CSA measurements for the bilateral PNs bilaterally were obtained. Images were also reviewed by an experienced neurologist to evaluate for inter-rater variability. The mean CSA of the right PN was 0.54 mm2 ± 0.16. The mean CSA of the left PN was 0.53 mm2 ± 0.18. We believe that the reference values for the normal CSA of the PNs obtained in our study could help in the sonographic evaluation of PN enlargement, as it relates to the diagnosis of various diseases affecting the PN. Furthermore, knowledge of its location and size, at the level of the scalene muscle, could help prevent PN-related complications during interventional procedures in that area.

Additionally, for each participant, demographic information of age and gender as well as body mass index, weight, and height were documented.
Treatment of Parkinson disease by acupuncture combined with medicine based on syndrome differentiation from the perspective of modern medicine: A review
Authors: Xia Xue , Dong Xu , Li Kaiqing , Song Jing , Tong Dan , Liu Yang , Han Yixiao , Wang Dongyan
Published: October 2023

As a multifactorial degenerative disease, Parkinson disease (PD) causes tremor, gait rigidity, and hypokinesia, which interfere with normal life. Because the disease is usually discovered in the late stage of complete degeneration of neurons, it can greatly delay treatment and even eventually lead to death. Therefore, the diagnosis of this disease is very challenging, and it is gratifying that substantial progress has been made in the development of optical coherence tomography (OCT) as a diagnostic biomarker for this disease, and genetic and imaging tests have become part of routine protocols in clinical practice. In the cognition of traditional Chinese medicine (TCM), this disease belongs to deficiency in origin and excess in superficiality, which is always caused by deficiency of liver and kidney, deficiency of qi and blood, and is closely related to wind, fire, phlegm and blood stasis. A large number of studies have shown that TCM can effectively treat motor and non-motor symptoms of PD, combat oxidative stress and reduce inflammatory response, and improve the quality of life of patients. Based on the pathophysiological mechanism of PD, this paper discusses the treatment of PD by TCM acupuncture combined with medicine based on syndrome differentiation.
Effectiveness of rational emotive behavior education (REBE) on computer anxiety among school teachers enrolled in e-learning
Authors: Onah Benardine Ifeoma , Ede Moses Onyemaechi , Eze Blessing Ngozi , Uzoegwu Chigozie Roseann , Mgboji Chukwuma , Agbo George Chibuike , Uzuagu Anthonia Uju , Chiamagu Charles , Agbo Philomina A , Oneli Joy Obiageli , Ogbueghu Sylvester N.
Published: October 2023

Background:

Reports from past studies indicated that research on anxiety disorder is not extensive and further investigation is needed using different populations. Besides, psychological intervention for computer anxiety has not been given the required empirical attention. Given this, we investigated the effectiveness of rational emotive behavior education on computer anxiety among primary school teachers enrolled in e-learning.

Methods:

A pure experimental design was used, which helped to randomly assigned recruited 112 primary school teachers to 2 arms (treatment and control groups). The Computer Anxiety Scale was distributed before, immediately after, and 4 weeks after completion of intervention with 12 sessions that were given to the treatment group.

Results:

The ANOVA results showed that rational emotive behavior education significantly decreased teachers computer anxiety. The mean computer anxiety score among instructors did not significantly differ by group or gender. Therefore, we recommended that computer educators, policymakers, and rational emotive behavior educators should organize rational and emotive-oriented conferences for schoolteachers.
Could BMMNCs therapy reduce the mid- and long-term rate of total hip arthroplasty of femoral head necrosis?: A systematic review and meta-analysis
Authors: Chen Xiao , Chen Jing , Duan Yanji , Chen Chang , Cao Yuan
Published: October 2023

Background:

Osteonecrosis of the femoral head (ONFH) is a cause of hip pain and early joint lesion in patient. The hip-preserving treatments are especially important for patients in early stage of ONFH. However, it is controversial of the effectiveness and safety of bone marrow mononuclear cells (BMMNCs) in the treatment of ONFH. The aim of the study was to explore the mid- and long-term efficacy (particularly the rate of total hip arthroplasty [THA]) with BMMNCs in treatment of ONFH.

Methods:

PubMed, Web of Science, Embase, OVID, Cochrane Libriary, CNKI, and Google Scholar databases were searched for relevant randomized controlled trials or non-randomized controlled trials from inception to October 15, 2022. Methodological quality of the trials was assessed, relevant data were extracted, and RevMan 5.3 and Stata 15.0 software were used to perform the meta-analysis of parameters related to the consequences.

Results:

A total of 22 articles were included, including 1923 patients. Meta-analysis results showed that the treatment of BMMNCs has a significantly lower incidence of THA (odds ratio [OR] = 0.33; 95% confidence interval [CI] = 0.27–0.41, P < .00001), radiographic progression rate (OR = 0.37; 95% CI = 0.21–0.63, P = .0003) and visual analog score at 24 months (mean difference [MD] = −11.84; 95% CI = −14.86 to −8.82, P < .00001), and has higher Harris hip score (MD = 6.90; 95% CI = 4.56–9.24, P < .00001), improvement of visual analog score at 24 months (MD = 6.87; 95% CI = 1.84–11.89, P = .007) and Merle D’Aubigne and Postel hip score (MD = 0.79; 95% CI = 0.14–1.44, P = .02). But there was no significant difference in the Western Ontario and McMaster University Osteoarthritis index (MD = −6.32; 95% CI = −16.76 to 4.12, P = .24) and incidence of complication (OR = 0.86; 95% CI = 0.52–1.42, P = .56).

Conclusion:

Current evidence supports that BMMNCs therapy could reduce the mid- and long-term rate of THA, improve hip function, alleviated the degree of hip pain, delay the progression of imaging staging and not increase the rate of complication, which maybe serve as a preferred option for treating ONFH.
Differences in postoperative knee joint function and prognostic quality of life in patients undergoing posterior cruciate ligament reconstruction at different surgical timing under enhanced recovery after surgery
Authors: Jin Xiaoyun , Xu Yuping
Published: October 2023

To explore the differences in postoperative knee joint function and prognostic quality of life in patients undergoing posterior cruciate ligament (PCL) reconstruction at different timing of surgery under the enhanced recovery after surgery (ERAS) protocol. A total of 266 cases of PCL injury admitted to our hospital between March 2019 and October 2022 were included in this retrospective study and divided them into a short-term group (147 cases with PCL reconstruction completed within 3 weeks after injury) and a long-term group (119 cases with PCL reconstruction performed 3 weeks after injury) according to the timing of surgery after injury. All patients received ERAS care during treatment. The operation time, intraoperative blood loss, and incision length of both cohorts were counted to evaluate the clinical efficacy. Perioperative patients were assessed by the Visual Analogue Scale for pain severity. The pre- and post-operative knee function and knee joint range of motion were assessed by the International Knee Documentation Committee and Lysholm Knee Scoring Scale. Furthermore, the complication rate was counted and the quality of life was evaluated by the Short-Form 36 Item Health Survey. Patients were also assessed for their psychological states using the Self-rating Anxiety/Depression Scale and their satisfaction with care. The 2 groups showed similar operation time, intraoperative blood loss, incision length, overall response rate, and Visual Analogue Scale (P > .05), but the short-term group had higher knee range of motion and scores of International Knee Documentation Committee and Lysholm Scale than the long-term group (P < .05). A similar complication rate was also determined in the 2 groups (P > .05), but the Short-Form 36 Item Health Survey scores were significantly higher in the short-term group (P < .05). Self-rating Anxiety Scale and Self-rating Depression Scale in both groups decreased after treatment (P < .05), and no statistical difference was determined in nursing satisfaction (P = 198). PCL reconstruction within 3 weeks after PCL injury is more conducive to the recovery of patients’ knee joint function, and the ERAS protocol can more effectively improve the therapeutic effect of patients.
Multiple primary melanomas: A literature review
Authors: Apostu Adina Patricia , Ungureanu Loredana , Halmagyi Salomea Ruth , Trufin Ioana Irina , Șenilă Simona Corina
Published: October 2023

Survival rates for melanoma have increased in recent years, a higher number of patients survive after diagnosis, and, therefore, are at an increased risk of developing second primary melanoma. The aim of this literature review is to identify and integrate the incidence rates and other characteristics of multiple primary melanomas. A total of 36 independent studies were included in this review. The incidence of multiple primary melanomas reported ranged from 1.1% to 20.4%. Synchronous melanomas account for 5% to 66% of the reported lesions. The most common site for both first and subsequent melanomas is the trunk. Superficial spreading melanoma is the most common histological type in both first and subsequent primary melanoma. Regarding the mean Breslow index, subsequent melanomas appeared to be thinner than first melanomas. Our review suggests that melanoma patients are at a higher risk of developing a second primary melanoma and long-term surveillance is needed.
Clinicopathological features and correlation analysis of male breast cancer
Authors: Xi Lei , Zhou Jinxing , Wu Yan , Rong Rong
Published: October 2023

To analyze and compare the clinicopathological characteristics of male breast cancer (MBC) among Chinese patients and those from East Asia and other regions. Clinicopathological data from 3 kinds of data sources, including 31 MBC patients in Jiangsu Provincial Hospital (JPH) from 2014 to 2021 in China, 20 literature data on East Asian MBC patients from 2014 to 2021, and 3102 MBC patients registered in the surveillance, epidemiology, and end results (SEER) database from 2014 to 2019, were collected and retrospectively analyzed. The average ages of first-diagnosis MBC patients in JPH and East Asian patients were 59.7 and 62.3 years old, respectively, which were younger than those of SEER patients (66.5 years old). Between East Asian and SEER patients, the status or rates of main breast cancer type, estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, breast subtype, and TNM stage were relatively close, and their differences were not statistically significant (P > .05). Differences were observed in chemotherapy, surgery, pathological grade, and lymph node positivity (P < .01). Furthermore, no statistically significant difference was observed between the JPH and East Asian patients (all P > .05). In JPH and SEER, linear regression relationships were observed between the lymph node positivity rate, tumor size, and histological grade. JPH and East Asian MBC patients were younger than SEER patients. Between East Asian and SEER patients, the status of the main breast cancer type, estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, breast subtype, and TNM stage were similar, but there were differences in chemotherapy, surgery, pathological grade, and lymph node positivity. The findings of this study should prove to be helpful to deepen our understanding of East Asian MBC.
A case report of Trousseau syndrome
Authors: Liu Xiao Jing , Liu Yu Xiang , Zhang Ning Yuan
Published: October 2023

Rationale:

In 1865, Trousseau first discovered pulmonary embolism caused by multiple venous thrombosis in patients with gastric cancer, and later all clinical manifestations of malignant patients during pathogenesis due to abnormal coagulation and fibrinolysis were referred to collectively as Trousseau syndrome. Trousseau syndrome is not a benign thrombophlebitis, and when diagnosed it requires immediate treatment. The survival rate over 1 year is only 12%. Stroke in cancer patients has distinct characteristics different from conventional stroke and has higher mortality.

Patient concerns:

A 54-year-old female presented to the Department of Otolaryngology with recurrent right nasal bleeding for 4 days. After surgery, the patient experienced 7 different cerebral infarction courses. Finally died of brain herniation.

Diagnosis:

The specific abnormal laboratory index is the increase of D-dimer, suggesting the hypercoagulation state. The patient developed multiple cerebral infarction, myocardial injury, renal infarction, splenic infarction, and lower extremity arterial thrombosis, and finally was diagnosed Trousseau syndrome.

Interventions:

In the treatment, aspirin and atorvastatin were selected, but it did not work very well. D-dimer were high, we used low molecular weight heparin, and D-dimer decreased significantly.

Outcomes:

Finally the patient died of brain herniation.

Conclusion:

The raise of D-dimer and typical magnetic resonance imaging manifestation which provides a greater basis for diagnosis. The specific abnormal laboratory index is the increase of D-dimer, which provides direction for treatment and helps to evaluate treatment effect.
Correlation between single nucleotide polymorphisms of folate metabolism genes and ethnic distribution in pregnant women
Authors: Huang Hua , He Jiangyan , Deng Dongyang , Chen Rong , Zhou Yiyuan
Published: October 2023

This retrospective study aims to identify the single nucleotide polymorphisms (SNPs) of 5,10-methylenetetrahydrofolate reductase (MTHFR) (C677T, A1298C), methionine synthase reductase (MTRR) (A66G) and ethnic distribution characteristics in pregnant women, and to explore the risk correlation with folate metabolism. The demographic data of 8735 pregnant women aged 15 to 47 years were retrospectively analyzed, and peripheral blood samples were collected and tested. Reverse transcription-quantitative polymerase chain reaction was applied to determine the genotype and allele frequency of MTHFR C677T, A1298C and MTRR A66G in blood samples. Sperman correlation analysis, univariate and multivariate logistic regression analysis were used to verify the correlation between SNPs of MTHFR (C677T, A1298C), MTRR (A66G), different ethnic groups and the susceptibility and risk levels of folate metabolism. The relative risk of the SNPs was further determined by calculating the odds ratio (OR) at a 95% confidence interval (CI). The average age of 8735 pregnant women was 28.87 ± 4.20 years old. The evaluation of risk levels for folate metabolism was relative high, including 2296 cases with low risk, 3971 cases with medium risk, and 752 cases with high risk. Among the MTHFR C677T locus, the CC genotype had the highest frequency, MTHFR A1298C locus had the highest frequency of the AA genotype, and MTRR A66G locus had the highest frequency of the AA genotype. The frequency distribution of SNPs in different ethnic groups revealed that the frequency of CT genotype among the MTHFR C677T locus, AA genotype among the MTHFR A1298C locus and the MTRR A66G locus was the highest in Han, Buyi, Miao and Dong ethnic groups. The results of logistic regression analysis showed that the Han, Buyi, Miao and other ethnic groups (including Yi, Bai, Zhuang, Chuanqing) had the possibility of increasing the risk levels of folate metabolism. The CC genotype of MTHFR C677T (adjusted OR = 2.46, 95% CI: 2.14–2.84, P < .001) and the AG genotype of MTRR A66G (adjusted OR = 1.89, 95% CI: 1.61–2.22, P < .001) were significantly related to the risk levels of folate metabolism, which is an independent risk factor for the susceptibility of folate metabolism.
Vasculitis mimicking immunoglobulin-G4-related disease with involvement of the submandibular and lacrimal glands and periaortitis: A case report
Authors: Kuribayashi Mamika , Odaka Hidesato , Takahashi Susumu , Tokairin Takuo , Kurokawa Hirokazu
Published: October 2023

Introduction:

Vasculitis does not usually induce glandular tissue lesions. Herein, we present a case of vasculitis with a distribution similar to that of immunoglobulin-G4-related disease (IgG4-RD), including that of the submandibular and lacrimal glands, and periaortitis.

Case report:

A 70-year-old man presented with shortness of breath. Laboratory findings revealed an IgG4 level of 191 mg/dL, negative antineutrophil cytoplasmic antibody test, and C-reactive protein level of 8.33 mg/dL. Magnetic resonance imaging of the head and computed tomography of the neck revealed bilaterally enlarged submandibular and lacrimal glands. Neck-to-pelvis computed tomography revealed bilateral infiltrative shadows in the lower lobes of both lungs, mass shadows in both lungs, and periaortitis of the abdominal aorta extending to the common iliac artery. Thus, the patient was diagnosed with IgG4-related respiratory disease and periaortitis/periarteritis. Prednisolone was administered at a dose of 35 mg (0.6 mg/kg daily). The dose was gradually tapered while observing the effects of the treatment. Imaging findings indicated an improvement and the C-reactive protein and IgG4 levels decreased, indicating a successful treatment course. However, after reexamination of the pathological findings, the diagnosis changed from IgG4-RD to vasculitis. One year after treatment initiation, the patient symptoms have stabilized.

Conclusion:

Vasculitis can present with lesions and pathological findings similar to those of IgG4-RD.
Network pharmacology and molecular docking analyses of the potential target proteins and molecular mechanisms underlying the anti-arrhythmic effects of Sophora Flavescens
Authors: Zhai Yuyun , Li Jinwei , Zhang Quan
Published: October 2023

The objective was to investigate the potential cardiac arrhythmia-related target proteins and molecular mechanisms underlying the anti-arrhythmic effects ofSophora flavescensusing network pharmacology and molecular docking. The bioactive ingredients and related target proteins ofS flavescensobtained from the Traditional Chinese medicine systems pharmacology data platform, and gene names for target proteins were obtained from the UniProt database. Arrhythmia-related genes were identified by screening GeneCards and Online Mendelian inheritance in man databases. A Venn diagram was used to identify the key arrhythmia-related genes that are potentially targeted by the bioactive ingredients ofS flavescens. Furthermore, CytoScape 3.7.2 software was used to construct an “ingredient-target” network diagram and the “drug-ingredient-target-disease” network diagram. We performed gene ontology and Kyoto encyclopedia of genes and genomes enrichment analysis in the Metascape database and performed the docking analysis using CB-Dock software. We identified 45 main bioactive ingredients, fromS flavescensand 66 arrhythmia-related target proteins. Gene ontology and Kyoto encyclopedia of genes and genomes pathway enrichment analysis showed that these targets were related to the chemical carcinogenesis-receptor activation signaling pathway, lipid and atherosclerosis signaling pathway, and fluid shear stress and atherosclerosis signaling pathway. Molecular docking showed that the target protein had good binding power with the main active components of the compound ofS flavescens. Our study demonstrated the synergistic effects of multiple bioactive components ofS flavescenson multiple arrhythmia-related target proteins and identified potential therapeutic mechanisms underlying the anti-arrhythmic effects ofS flavescens, providing new clinical ideas for arrhythmia treatment.
Factors associated with Pap test screening among South Korean women aged 20 to 39 years
Authors: Seo Yun Am , Kim Young A
Published: October 2023

The number of hospital visits with cervical cancer as the chief complaint among South Korean women aged 20 to 39 has increased by 1.2 times between 2016 and 2020, indicating a need for active screening for the disease. This study aimed to investigate the status of the Papanicolaou (Pap) test and identify factors influencing Pap test experience among South Korean women aged 20 to 39 years. An online questionnaire survey was conducted over 5 days starting from November 19, 2021. A total of 338 participants who were randomly sampled by age completed the survey. Data were analyzed using descriptive statistics, t test, χ
2 test, and logistic regression. The mean age of the participants was 29.9 years, and participants with and without Pap test experience accounted for 60.7% and 39.3% of the total, respectively. There were significant differences in age, marital status, employment status, smoking status, experience of coitus, awareness of the National Cancer Screening Program, and human papillomavirus (HPV) vaccination status according to the Pap test experience (P < .05) of the participants. Pap test attitude, Pap test self-efficacy, cervical cancer knowledge, HPV knowledge, and cancer prevention behavior scores were significantly higher in the Pap test experience group than in the no Pap test experience group (P < .05). Logistic regression analysis showed that experience of coitus (odds ratio [OR] = 10.46, 95% confidence interval [CI]: 4.54–24.11), marital status (OR = 5.96, 95% CI: 2.25–15.77), awareness of the National Cancer Screening Program (OR = 4.39, 95% CI: 1.66–11.58), HPV vaccination (OR = 2.62, 95% CI: 1.35–5.09), employment status (OR = 2.22, 95% CI: 1.08–4.59), and self-efficacy (OR = 1.09, 95% CI: 1.01–1.19) were the influencing factors in the Pap test experience group. To improve the Pap test screening rate among South Korean women aged 20 to 39, reinforcement strategies and intervention programs that involve age-specific approaches must be established.
Knowledge structure and emerging trends of cognitive impairment induced by sleep deprivation: A bibliometric analysis based on CiteSpace and VOSviewer from 2000 to 2022
Authors: Yu Kai , Hao Lei , Bu Fan , Guo Yuanzhi , Duan Yaqi , Hu Rui , Lu Ji , Li Peng
Published: October 2023

This paper implements a bibliometric approach to investigate the research hotspots and future research directions in the relevant field literature. It also offers research ideas and methods for preventing and treating cognitive impairment induced by sleep deprivation in the clinical setting. The evolution of various clusters in the field is summarized through Citespace’s projection function for keywords in the literature. CiteSpace and Vosviewer are utilized to analyze and visualize the attributes of the articles, including number of publications, citation frequency, country/region, institution, journal, authors, keywords, and references, from the 2280 publications obtained. A total of 2280 publications were collected, with the number of papers and citations in the field continuously increasing year by year. The most influential country in this field is the United States, and the University of Washington is the most influential institution. The most authoritative journal in the field is identified as SLEEP. Sleep deprivation, prefrontal cortex, and performance are the current topics of interest. The article with the strongest citation burst, lasting from 2015 to 2018, is “Sleep Drives Metabolite Clearance from the Adult Brain.” The most influential article and co-cited reference, “Neurocognitive Consequences of Sleep Deprivation,” highlights that sleep deprivation from various causes may lead to cognitive impairment. Future research should investigate all forms of cognitive impairment resulting from sleep deprivation. The findings of this study will assist researchers in improving their knowledge structure, identifying research hotspots, and revealing future directions in the field.
The influence of pupil diameter upon and subjective quality of vision following implantable collamer lens (ICL V4c) implantation: An observational study
Authors: Zhang Qing , Wu Yi , Huang He , Qin Guanghao , Li Liangzhe , Chen Jiayan , Che Huixin , Xu Ling , Moore Jonathan E. , He Wei , Yu Sile , Pazo Emmanuel Eric , He Xingru
Published: October 2023

This study aimed to assess the change in pupil size and its influence on subjective quality of vision (QoV) in subjects with implanted collamer lenses (ICLs). This retrospective study assessed 53 participants (53 eyes) implanted with ICL (V4c) and categorized them into incremental groups according to pupil diameter. Preoperative and postoperative photopic and mesopic pupil diameter, uncorrected distance visual acuity (UDVA), and QoV questionnaire scores were assessed and compared. Postoperatively, at 3 months, UDVA was −0.10 ± 0.06 logarithm of the minimum angle of resolution (LogMAR), and mean QoV for day and night was 9.34 ± 0.76 and 8.58 ± 1.29, respectively. The mean mesopic and photopic pupil diameters were 6.59 ± 0.79 mm and 4.61 ± 0.74 mm, respectively. Photopic pupil diameter negatively correlated with “QoV day” (Rs = −0.413, P = .001), positively correlated with “haloes” (Rs = 0.568*, P < .001) and “blurred vision” (Rs = 0.243, P = .04) respectively. Mesopic pupil diameter negatively correlated with “QoV night” (Rs = −0.426, P = .001), positively correlated with “haloes” (Rs = 0.624*, P < .001), “starburst” (Rs = 0.233, P = .046) and “difficulty focusing” (Rs = 0.27, P = .025), respectively. Participants had excellent VA at 3-month follow-up. Photopic and mesonic pupil diameter negatively correlated with QoV day and QoV night scores, respectively. Pupil diameter was found to have a more significant effect on visual symptoms at night, and lower QoV due to larger pupil size was more noticeable at night. Further investigation is needed to explore the importance of pupil diameter and its impact on the QoV in ICL implanted patients.
Identification and verification of an exosome-related gene risk model to predict prognosis and evaluate immune infiltration for colorectal cancer
Authors: Shao Huan , Yao Li , Tao Ye , Huang Xuan
Published: October 2023

Colorectal cancer (CRC) is a common malignant tumor that severely endangers human health. Exosomes show great potential in tumor immunotherapy. Increasingly studies have shown that exosome-related genes are effective prognostic biomarkers. Clinical information and gene expression data of CRC patients were obtained from gene expression omnibus and the cancer genome atlas. The data were then classified into training and independent validation sets. In the training set, exosome-related genes with a prognostic value were selected by univariate Cox analysis, least absolute shrinkage and selection operator Cox regression model, and stepwise Cox regression analysis. Risk scores were calculated based on the selected genes to stratify patients. The selected exosome-related genes were applied to establish a risk model. Based on 11 exosome-related genes, a prognostic risk model, which could stratify the risk both in the training and validation sets, was established. According to the survival curves, the prognoses of the high- and low-risk groups were significantly different. The AUCs of the risk model for prognostic prediction were 0.735 and 0.784 in the training and validation sets, respectively. A nomogram was constructed to predict the survival of CRC patients. Single-sample gene set enrichment analysis and ESTIMATE algorithms revealed that the risk model was related to immune cell infiltration. The value of the risk model in predicting immunotherapeutic outcomes was also confirmed. An exosome-related gene risk model was constructed to predict prognosis, evaluate microenvironment immune cell infiltration levels and bring a new perspective to CRC patient treatment.
Effect of total quality management intervention on nurse commitment and nurse performance: A quasi-experimental study
Authors: Alzoubi Majdi M. , KS Hayati , AM Rosliza , Al-Zoubi Khaled M. , AL-Mugheed Khalid , Alsenany Samira A. , Oweidat Islam , Abdelaliem Sally M.F.
Published: October 2023

Background:

The purpose of this study is to design, implement, and evaluate the impact of a total quality management intervention on job performance and commitment among Jordanian nurses working in government hospitals.

Methods:

A quasi-experimental multiple time series was conducted starting in September 2017 and ending in June 2018. 140 nurses were sampled using the proportionate stratified random sampling technique; 132 were completed the study 67 the intervention group, while 65 in the control group.

Results:

There were no significant differences in nurses’ job performance or commitment between the 2 groups (control and intervention). A repeated measure MANOVA test for both groups revealed that the interaction between group and time was statistically significant (F (4, 127) = 144.841; P = .001; Wilk’s Λ = 0.180; η2 = .820), indicating that groups had a significantly different pattern of job performance and commitment over time. A repeated test The MANCOVA test for both groups across time revealed significant differences in nurses’ job performance and nurses’ commitment at a less than 0.05 significance level (F (2127) = 320.724; P = .001; Wilk’s Λ = 0.165; η2 = 0.835), and the overall effect of time was significant for all dependent variables (F (4125) = 36.879; P = .001; Wilk’s Λ = 0.459; η2 = 0.541).

Conclusion:

The educational intervention was effective in improving nursing job performance among the study sample. The improved commitment of respondents in the intervention group was attributed to the improvement in job performance.