bluuebunny/crossref_metadata_2025 huggingface dataset:
A 96-WELL VALVED MICROFLUIDIC DEVICE FOR TESTING OF LIVE INTACT TUMOR CUBOIDS
Authors: Lockhart Ethan J. , Horowitz Lisa F. , Lim Cb , Nguyen Tran , Mehrabi Mehdi , Gujral Taranjit S. , Folch Albert
Published: July 2022

There is a pressing need for functional testing platforms that use human, live tumor tissue to better predict traditional and immunotherapy responses. Such platforms should also retain as much of the native tumor microenvironment (TME) as possible, as many cancer drug actions rely on TME-dependent mechanisms. Present high-throughput testing platforms that have some of these features, e.g. based on patient-derived tumor organoids, require a growth step that alters the TME. On the other hand, micro-dissected tumor tissue “spheroids” that retain an intact TME have shown promising responses to immunomodulators acting on native immune cells. Here we demonstrate a microfluidic 96-well platform designed for drug treatment of hundreds of similarly-sized, cuboidal micro-tissues (“cuboids”) produced from a single tumor sample. Four cuboids per well are automatically arrayed into the platform using hydrodynamic trapping. The microfluidic device, entirely fabricated in thermoplastics, features microvalves that fluidically isolate each well after the cuboid loading step. Since the platform effectively makes the most of scarce tumor tissue, we believe it could ultimately be applied to human biopsies for drug discovery and personalized oncology, altogether bypassing animal testing.
RNA polymerase II and PARP1 shape enhancer-promoter contacts
Authors: Barshad Gilad , Lewis James J. , Chivu Alexandra G. , Abuhashem Abderhman , Krietenstein Nils , Rice Edward J. , Rando Oliver J. , Hadjantonakis Anna-Katerina , Danko Charles G.
Published: July 2022

How enhancers control target gene expression over long genomic distances remains an important unsolved problem. Here we studied enhancer-promoter contact architecture and communication by integrating data from nucleosome-resolution genomic contact maps, nascent transcription, and perturbations to transcription-associated proteins and thousands of candidate enhancers. Contact frequency between functionally validated enhancer-promoter pairs was most enriched near the +1 and +2 nucleosomes at enhancers and target promoters, indicating that functional enhancer-promoter pairs spend time in close physical proximity. Blocking RNA polymerase II (Pol II) caused major disruptions to enhancer-promoter contacts. Paused Pol II occupancy and the enzymatic activity of poly (ADP-ribose) polymerase 1 (PARP1) stabilized enhancer-promoter contacts. Based on our findings, we propose an updated model that couples transcriptional dynamics and enhancer-promoter communication.
CBP60-DB: An AlphaFold-predicted plant kingdom-wide database of the CALMODULIN-BINDING PROTEIN 60 (CBP60) protein family with a novel structural clustering algorithm
Authors: Amani Keaun , Shivnauth Vanessa , Castroverde Christian Danve M.
Published: July 2022

Molecular genetic analyses in the model speciesArabidopsis thalianahave demonstrated the major roles of different CAM-BINDING PROTEIN 60 (CBP60) proteins in growth, stress signaling, and immune responses. Prominently, CBP60g and SARD1 are paralogous CBP60 transcription factors that regulate numerous components of the immune system, such as cell surface and intracellular immune receptors, MAP kinases, WRKY transcription factors, and biosynthetic enzymes for immunity-activating metabolites salicylic acid (SA) andN-hydroxypipecolic acid (NHP). However, their function, regulation and diversification in most species remain unclear. Here we have created CBP60-DB, a structural and bioinformatic database that comprehensively characterized 1052CBP60gene homologs (encoding 2376 unique transcripts and 1996 unique proteins) across 62 phylogenetically diverse genomes in the plant kingdom. We have employed deep learning-predicted structural analyses using AlphaFold2 and then generated dedicated web pages for all plant CBP60 proteins. Importantly, we have generated a novel clustering visualization algorithm to interrogate kingdom-wide structural similarities for more efficient inference of conserved functions across various plant taxa. Because well-characterized CBP60 proteins inArabidopsisare known to be transcription factors with putative calmodulin-binding domains, we have integrated external bioinformatic resources to analyze protein domains and motifs. Collectively, we present a plant kingdom-wide identification of this important protein family in a user-friendly AlphaFold-anchored database, representing a novel and significant resource for the broader plant biology community.
Cortico-cerebellar coordination facilitates neuroprosthetic control
Authors: Abbasi Aamir , Rangwani Rohit , Bowen Daniel W. , Fealy Andrew W. , Danielsen Nathan P. , Gulati Tanuj
Published: July 2022

Temporal coordination among neurons and development of functional neuronal assemblies is central to nervous system function and purposeful behavior. Still, there is a paucity of evidence about how functional coordination emerges in task-related neuronal assemblies in cortical and subcortical regions that are related to the control of functional output. We investigated emergent neural dynamics between primary motor cortex (M1) and the contralateral cerebellar cortex as rats learned a neuroprosthetic/ brain machine interface (BMI) task. BMIs offer a powerful tool to causally test how distributed neural networks achieve specific neural activation. During neuroprosthetic learning, actuator movements are causally linked to primary motor cortex (M1) neurons, i.e.,“direct”neurons, that drive the decoder and whose firing is required to successfully perform the task. However, it is unknown how task-relatedM1activity interacts with cerebellar activity. We observed a striking 3–6 Hz coherence that emerged between these regions’ local–field potentials (LFPs) with neuroprosthetic learning which also modulated task-related spiking. We found a robust task-related indirect modulation in the cerebellum, and we found that this activity developed a preferential relationship withM1task-related direct and indirect activity but not with M1 task unrelated activity with learning. We also performed optogenetic inhibition of cerebellar activity (in the cerebellar cortex and its deep nuclei) and found that this led to performance impairments inM1–driven neuroprosthetic control. Together, these results demonstrate that coordinated neural dynamics emerge in cortico-cerebellar regions during neuroprosthetic learning which supports task-relevant activity inM1neuronal populations, and further, that cerebellar influence is necessary forM1–driven neuroprosthetic control.
Carbohydrate-Binding Protein from Stinging Nettle as Fusion Inhibitor for SARS-CoV-2 Variants of Concern
Authors: Vanhulle Emiel , D’huys Thomas , Provinciael Becky , Stroobants Joren , Camps Anita , Noppen Sam , Schols Dominique , Van Damme Els J.M. , Maes Piet , Stevaert Annelies , Vermeire Kurt
Published: July 2022

Urtica dioica agglutinin (UDA) is a carbohydrate-binding small monomeric protein isolated from stinging nettle rhizomes. It inhibits replication of a broad range of viruses, including coronaviruses, in multiple cell types, with appealing selectivity. In this work, we investigated the potential of UDA as a broad-spectrum antiviral agent against SARS-CoV-2. UDA potently blocks entry of pseudotyped SARS-CoV-2 in A549.ACE2+-TMPRSS2 cells, with IC50 values ranging from 0.32 to 1.22 µM. Furthermore, UDA prevents viral replication of the early Wuhan-Hu-1 strain in Vero E6 cells (IC50 = 225 nM), but also the replication of SARS-CoV-2 variants of concern, including Alpha, Beta and Gamma (IC50 ranging from 115 to 171 nM). In addition, UDA exerts antiviral activity against the latest circulating Delta and Omicron variant in U87.ACE2+ cells (IC50 values are 1.6 and 0.9 µM, respectively). Importantly, when tested in Air-Liquid Interface (ALI) primary lung epithelial cell cultures, UDA preserves antiviral activity against SARS-CoV-2 (20A.EU2 variant) in the nanomolar range. Surface plasmon resonance (SPR) studies demonstrated a concentration-dependent binding of UDA to the viral spike protein of SARS-CoV-2, suggesting interference of UDA with cell attachment or subsequent virus entry. Moreover, in additional mechanistic studies with cell-cell fusion assays, UDA inhibited SARS-CoV-2 spike protein-mediated membrane fusion. Finally, pseudotyped SARS-CoV-2 mutants with N-glycosylation deletions in the S2 subunit of the spike protein remained sensitive to the antiviral activity of UDA. In conclusion, our data establish UDA as a potent and broad-spectrum fusion inhibitor for SARS-CoV-2.
[(1,2,5,6-η)-Cycloocta-1,5-diene](4-isopropyl-1-methyl-1,2,4-triazol-5-ylidene)(tricyclohexylphosphane-κP)iridium(I) tetrafluoridoborate dichloromethane monosolvate
Authors: Rushlow Joshua , Astashkin Andrei V. , Albert Daniel R. , Rajaseelan Edward
Published: July 2022

The title compound, [Ir(C8H12)(C6H11N3)(C18H33P)]BF4·CH2Cl2, a triazole-based N-heterocyclic carbene iridium(I) cationic complex with a tetrafluoridoborate counter-anion, crystallizes with one dichloromethane solvent molecule per formula unit. The IrI atom of the cationic complex has a distorted square-planar coordination environment, defined by a bidentate cycloocta-1,5-diene (COD) ligand, an N-heterocyclic carbene, and a tricyclohexylphosphane ligand. The complex crystallizes in a C-centered monoclinic unit cell and has an unusually high number of eight formula units.
A DEA-ANN-based analytical framework to assess and predict the efficiency of Canadian universities in a service supply chain context
Authors: Jauhar Sunil Kumar , Zolfagharinia Hossein , Amin Saman Hassanzadeh
Published: July 2022

Purpose

This research is about embedding service-based supply chain management (SCM) concepts in the education sector. Due to Canada's competitive education sector, the authors focus on Canadian universities.

Design/methodology/approach

The authors develop a framework for evaluating and forecasting university performance using data envelopment analysis (DEA) and artificial neural networks (ANNs) to assist education policymakers. The application of the proposed framework is illustrated based on information from 16 Canadian universities and by investigating their teaching and research performance.

Findings

The major findings are (1) applying the service SCM concept to develop a performance evaluation and prediction framework, (2) demonstrating the application of DEA-ANN for computing and predicting the efficiency of service SCM in Canadian universities, and (3) generating insights to enable universities to improve their research and teaching performances considering critical inputs and outputs.

Research limitations/implications

This paper presents a new framework for universities' performance assessment and performance prediction. DEA and ANN are integrated to aid decision-makers in evaluating the performances of universities.

Practical implications

The findings suggest that higher education policymakers should monitor attrition rates at graduate and undergraduate levels and provide financial support to facilitate research and concentrate on Ph.D. programs. Additionally, the sensitivity analysis indicates that selecting inputs and outputs is critical in determining university rankings.

Originality/value

This research proposes a new integrated DEA and ANN framework to assess and forecast future teaching and research efficiencies applying the service supply chain concept. The findings offer policymakers insights such as paying close attention to the attrition rates of undergraduate and postgraduate programs. In addition, prioritizing internal research support and concentrating on Ph.D. programs is recommended.
Local habitus and temporal overtourism in Yogyakarta
Authors: Purwandani Intan , Pakan Sarani Pitor
Published: July 2022

Purpose

This paper aims to unpack personal narratives of local residents in relation to the effects of overtourism in Yogyakarta, Indonesia. The paper uses Pierre Bourdieu’s concept of habitus to understand how local residents cope with temporal overtourism.

Design/methodology/approach

Findings were gathered from observations and interviews. Interviews were conducted with 12 informants, consisting of local small-to-medium enterprise tourism entrepreneurs, local informal tourism workers and a group of locals uninvolved in tourism.

Findings

The paper has two key findings. First, locals uninvolved in tourism show empathetic behavior toward the locals involved in tourism despite their experiencing negative effects of tourism. The involved locals, for their part, were aware of the importance of resolving issues with the uninvolved locals through regular communication so as to secure the sustained future of tourism. Second, the use of social capital by involved and uninvolved locals reflects the local Javanese culture and value system in which social harmony and integration are paramount.

Research limitations/implications

Local habitus forms and informs locals’ perceptions on temporal overtourism issues. It enables an understanding on how locals manage the effects of overtourism in Yogyakarta. The habitus, which is greatly influenced by Javanese values, creates attitudes and behaviors which are empathetic and tolerant.

Practical implications

To avoid the potential conflict when overtourism explicitly or implicitly frustrates locals, policy should be formulated by taking into account the findings of this paper on the local habitus. The study contributes to the overtourism debate by looking at the inter-relationship of local social structures and cultural context with local responses to temporal overtourism.

Originality/value

Using the concept of habitus, this research deepens existing understanding on the local responses toward overtourism. This research expects to theoretically enrich and complexify debates on tourism–habitus nexus in tourism studies.
Regulatory-focused job crafting, person-job fit and internal employability–examining interrelationship and underlying mechanism
Authors: Sameer Sanjeet Kumar , Priyadarshi Pushpendra
Published: July 2022

Purpose

This paper examines the relationships between regulatory-focused job crafting, i.e. promotion- and prevention-focused job crafting, person-job fit and internal employability and explores the direct and underlying mediation process using conservation of resources and job demands-resources theories.

Design/methodology/approach

Survey data collected from 425 executives of India based public sector enterprises were used to test hypotheses.

Findings

Promotion- and prevention-focused job crafting respectively had a contrasting relationship with needs-supplies fit. The relationship with demands-abilities fit was statistically significant only in the case of prevention-focused job crafting. These two job crafting forms respectively had a positive and a negative effect on internal employability, both directly as well as indirectly through person-job fit.

Practical implications

Employees can pursue promotion-focused job crafting and avoid prevention-focused job crafting to improve their person-job fit as well as internal employability which subsequently may have multiple favourable outcomes at an organizational and individual level.

Originality/value

The study, for the first time, empirically investigates the differential role of individuals' efforts in the form of promotion- and prevention-focused job crafting, in influencing internal employability and explains its underlying mechanism through person-job fit. These interrelationships may have important implications for employees' job demand management process and job choices.
Client and contractor perspectives on attributes affecting construction quality in a war-affected region
Authors: Zaray Abdul Habib , Hasan Abid , Johari Sparsh , Hashmat Parvez Ahmad , Jha Kumar Neeraj
Published: July 2022

Purpose

The poor quality of construction work in war-affected regions is a significant issue. The large-scale destruction to the existing infrastructure from the war necessitates cost and time-efficient delivery of construction projects during and post-war to bring normalcy to affected lives and places. Consequently, there is always a tendency to finish construction projects in the shortest possible time on a limited budget without following the proper quality management processes. However, the poor quality of construction projects continues to affect the country's development, growth, credibility, reputation, and public safety for several years after the war. To this end, the present study was conducted to evaluate the significant attributes and factors contributing to the poor quality of construction projects in the war-affected Afghan construction sector.

Design/methodology/approach

A total of 31 attributes influencing construction project quality were ranked based on 110 completed survey responses collected from Afghan construction professionals. Moreover, independent samples t-test, Spearman's rank correlation test, and exploratory factor analysis were conducted.

Findings

The study found a moderate consensus between clients and contractors on attributes' rankings. In addition, the independent samples t-test showed statistically significant differences in means values of responses from clients and contractors for eight attributes. Based on factor analysis, 19 important attributes (median value greater than or equal to four) were classified into 4 latent factors – (1) poor-quality assurance and control, (2) unethical practices, (3) design and drawing errors, and (4) knowledge and skills gap.

Originality/value

Evaluating the factors affecting the quality of construction projects will help clients, government departments, and construction practitioners improve the construction quality management practices. The findings will also inform the policies and procedures of international aid providers.
A structural equation model to assess the effects of strategic and project related potential risks on project delivery in Qatar
Authors: Gunduz Murat , Abumoza Abdulla M. , Aly Aly Abdelfattah
Published: July 2022

Purpose

The aim of this paper is to study the effect of strategic and project related potential risks on project delivery in Qatar. Two objectives have been defined. The first is to identify potential risk indicators (manifest variables) and categorize them (constructs/latent variables) based on a literature review, while the second is to examine and rank the relationships between the indicators and constructs by developing a structural equation model.

Design/methodology/approach

Twenty-five indicators were identified from the literature review and categorized into five groups. To collect the data, an online questionnaire was distributed in Qatar, and 116 responses were obtained. Structural equation modeling (SEM) was used to examine the model. The model that was developed based on the research hypothesis met goodness-of-fit, reliability and validity requirements.

Findings

The results showed that all constructs contributed well to the model and that the project parties (PPs) have the highest contribution with an effect weight of 0.209 followed by economic and legal (EL) conditions with an effect weight of 0.205. Site and safety (SS) conditions were third with an effect weight of 0.200 while environmental, natural and technological (ENT) conditions were fourth with an effect weight of 0.1989. The last ranked construct is political and social (PS) conditions with an effect weight of 0.186. Based on the outcome of the SEM, recommendations were provided to industry professionals in Qatar about mitigating the impact of potential risks on construction project.

Originality/value

To the authors' best knowledge, this is the first study to quantify the effects of strategic and project related risks on a construction project using SEM, considering the risk management indicators of SS, EL, ENT, PS in Qatar. The study's practical implications are to enlarge the project's risk management plan by considering the strategic and project related risks to enhance the project performance for the cost overrun and delay. The study is intended for construction projects in Qatar, but it can easily be adapted to other parts of the world given the local circumstances.
To predict and to explain: a multigroup analysis of gender on job and family satisfaction among hospitality employees
Authors: Tan Kim-Lim , Sim Adriel K.S. , Donohue Thomas
Published: July 2022

Purpose

The recent trends of work and family issues have prompted a proliferation of research in the work-family study; however, evidence from the hospitality industry is limited. This paper aims to examine the relationships between the work-family interface on job satisfaction (JS) and family satisfaction (FS). Additionally, the authors have adopted person-centered perspectives to determine if gender affects the magnitude of these relationships.

Design/methodology/approach

Data were collected from 295 hospitality employees, and the hypotheses were tested using the partial least squares method of structural equation modeling. Other than assessing the path model’s explanatory power, the authors examined the model’s predictive power using PLSpredict to predict new cases.

Findings

The results supported the originating domain view where the domain in which work-family enrichment (WFE) or conflict originates would have the immediate effect. Simultaneously, the authors found empirical evidence demonstrating the complimentary transfer of resources from the family domain to the work domain, enriching an individual’s satisfaction level. Finally, multigroup analysis reveals that women displayed higher job dissatisfaction than men when facing work-family conflict.

Originality/value

To the best of the authors’ knowledge, this study is the first study that allows a better understanding of the effect of the COVID-19 pandemic on employees’ work-family dynamics. This is the first study relating WFE and conflict to matching-domain satisfaction in one model. By examining these constructs’ simultaneous pathways, the authors extend the body of knowledge by contrasting the source attribution perspective with the cross-domain theory of enrichment and conflict. Consequentially, the authors answer Premchandran and Priyadarshi’s (2020) call to examine work-family dynamics in different cultures on different genders.
A bibliometric review of research on employability: dataset from Scopus between 1972 and 2019
Authors: Dinh Ngoan Thi , Dinh Hai Luong , Pham Hiep-Hung
Published: July 2022

Purpose

Employability has long been a concern of scholars because of its complicated nature and changes in the requirements in labor markets to meet the new requirements of the Industrial Revolution 4.0 and globalization. However, there has not yet been much systematic investigation of the existing literature tracing the trends, changes and developments in employability research. This paper aims to fill this void by analyzing data obtained from the Scopus dataset from 1972 to 2019.

Design/methodology/approach

A total of 1,703 Scopus-indexed articles were filtered from 7,885 documents. The results reflect a rapidly emerging literature on employability, given the worldwide interest in this topic. Using descriptive statistics and bibliometric analyses, the review identified trends in employability research, whose impact has been sustained for several decades.

Findings

With science mapping, the conceptual structure of scientific disciplines was visualized, highlighting three main schools of thought including employers’ requirements and higher education institutions’ preparation; the antecedents of employability; and the role of work-integrated learning in enhancing employability.

Originality/value

The paper calls for more integrative research focusing on personal agency with the development of career paths inside organizations as well as for a more focus on a multilevel perspective exploring both individuals' and organizations’ perceptions.
Impact of institutional quality and human capital creation on economic growth in Bangladesh: evidence from an ARDL approach
Authors: Islam Md. Saiful , Mustafa Shindaini Al Jamal
Published: July 2022

Purpose

This study examines the impact of institutional quality (INQ) and human capital creation (HCC) on economic growth (EG) linkage in Bangladesh using an ARDL approach.

Design/methodology/approach

This study uses time-series annual data over the period 1990–2019. It formulates an INQ index based on international country risk guide (ICRG) data, employs public education outlay and expenditure on health data each as a portion of real gross domestic product (GDP) to measure HCC, while an increase in real GDP is used as a proxy for EG. It employs the ARDL technique and Toda–Yamamoto (T-Y) causality check to realize the study.

Findings

The ARDL analysis divulges that the variables have a long-run association; INQ affects long-run EG positively; expenditure on health stimulates EG rate in the long run, but does not impact the latter in the short-run; whilst government spending on education impacts long-term EG rate negatively but positively in the short-term. The T-Y causality test results reveal a feedback relationship between INQ and EG, and one-way causation from health expenditure to EG rate, and education outlay to EG rate and authenticate the ARDL estimation results.

Originality/value

The study is original. The novelty of the study is to employ an INQ index using the ICRG data on 12 different components which are converted into a single index through principal component analysis.

Peer review

The peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-12-2021-0732
A hybrid obstacle avoidance method for mobile robot navigation in unstructured environment
Authors: Zhou Huaidong , Feng Pengbo , Chou Wusheng
Published: July 2022

Purpose

Wheeled mobile robots (WMR) are the most widely used robots. Avoiding obstacles in unstructured environments, especially dynamic obstacles such as pedestrians, is a serious challenge for WMR. This paper aims to present a hybrid obstacle avoidance method that combines an informed-rapidly exploring random tree* algorithm with a three-dimensional (3D)-object detection approach and model prediction controller (MPC) to conduct obstacle perception, collision-free path planning and obstacle avoidance for WMR in unstructured environments.

Design/methodology/approach

Given a reference orientation and speed, the hybrid method uses parametric ellipses to represent obstacle expansion boundaries based on the 3D target detection results, and a collision-free reference path is planned. Then, the authors build on a model predictive control for tracking the collision-free reference path by incorporating the distance between the robot and obstacles. The proposed framework is a mapless method for WMR.

Findings

The authors present experimental results with a mobile robot for obstacle avoidance in indoor environments crowded with obstacles, such as chairs and pedestrians. The results show that the proposed hybrid obstacle avoidance method can satisfy the application requirements of mobile robots in unstructured environments.

Originality/value

In this study, the parameter ellipse is used to represent the area occupied by the obstacle, which takes the velocity as the parameter. Therefore, the motion direction and position of dynamic obstacles can be considered in the planning stage, which enhances the success rate of obstacle avoidance. In addition, the distance between the obstacle and robot is increased in the MPC optimization function to ensure a safe distance between the robot and the obstacle.
Determinants of cross-cultural adjustment among self-initiated expatriate medical doctors working in Ireland
Authors: Nolan Eimear , Liang Xiaoning
Published: July 2022

Purpose

The last decade has seen a significant increase in self-initiated expatriation research across various cohorts; however, limited research exists on the self-initiated expatriation of medical doctors despite their high mobility rates. The purpose of this paper is to investigate the determinants of cross-cultural adjustment among self-initiated medical doctors working and living in a host culture.

Design/methodology/approach

A questionnaire was distributed to self-initiated expatriate (SIE) doctors working in Irish hospitals. In total, 193 valid responses were collected. Three linear regression analyses were conducted to explore factors influencing cross-cultural adjustment among SIE medical doctors, along with qualitative insight into their adjustment to working and living in Ireland.

Findings

This study found that age, marital status, cultural novelty, previous international work experience, length of time working in the host culture did not influence the cross-cultural adjustment of SIE doctors. However, gender, language ability and perceived fair treatment were found to influence their cross-cultural adjustment in the study. Specifically, female SIE doctors reported higher levels of general adjustment to that of SIE male doctors. SIE doctors' language ability was found to influence their work adjustment, and those who perceived unfair treatment in the host culture reported lower levels of general adjustment.

Originality/value

This paper contributes to the limited knowledge and understanding surrounding the self-initiated expatriation of medical doctors and their cross-cultural adjustment to the host hospital and host culture.
Determinants of KMS adoption in Malaysian organizations: evidence across various industries
Authors: Aman Fadhilah , Yusof Khairul Huda
Published: July 2022

Purpose

This article investigates the determinants of knowledge management system (KMS) adoption, specifically with reference to Malaysian organizations across various industries.

Design/methodology/approach

The structural equation modelling approach using PLS technique was utilized to analyze the hypotheses developed, based on the survey data from 830 respondents comprised of information technology or knowledge management managers in Malaysian organizations from various industries.

Findings

Knowledge management (KM) enabling processes, perceived usefulness of KMS, knowledge sharing culture, knowledge taxonomy, and policy and procedure for KMS work, display significant positive effects on the KMS adoption level, with KM enabling processes having the strongest significant positive influence. Meanwhile, incentive and reward, management commitment, and KMS perceived ease of use possess no significant direct effect. However, management commitment was found to have an indirect effect on the KMS adoption level, where its effect is mediated by knowledge sharing culture.

Practical implications

This article outlines several managerial implications for enhancing the adoption of KMS, which include establishing appropriate KM enabling processes, identifying pertinent information to be preserved, shared, and reuse, and generating initiatives to instil a culture of knowledge sharing.

Originality/value

The empirical findings support the relevancy of the technology acceptance model (TAM) construct of perceived usefulness in KMS adoption context and advances the understanding that knowledge sharing culture is a highly influential factor for this construct. This study enriches and extends technology acceptance theory by presenting a more holistic model for KMS adoption with the integration of influencing factors that are inherent to organization.
Safety, efficacy, and drug survival of the infliximab biosimilar CT‐P13 in post‐marketing surveillance of Japanese patients with psoriasis
Authors: Morita Akimichi , Nishikawa Kiyohiro , Yamada Fumika , Yamanaka Keiichi , Nakajima Hideki , Ohtsuki Mamitaro
Published: July 2022

Based on extrapolation of similar clinical outcomes in rheumatoid arthritis to the originator infliximab (IFX) in randomized clinical trials, the first biosimilar antibody CT‐P13 was approved for the treatment of psoriasis. To evaluate the safety, efficacy, and drug survival of CT‐P13 for psoriasis in real‐world clinical practice, prospective post‐marketing surveillance was conducted in 165 Japanese psoriasis patients. During a 1‐year follow‐up period, adverse drug reactions (ADRs) occurred in 29 patients (17.6%). Infusion reaction was the most frequent ADR (6.7%), and mild pneumonia was reported as the only case of infection. Serious ADRs were reported in two patients (1.2%): acute cholecystitis and interstitial pneumonia. The interstitial pneumonia developed after a single infusion of CT‐P13 and the patient died of respiratory failure. In naive patients to biologic therapy (n = 44), the Psoriasis Area Severity Index (PASI) decreased rapidly after the start of CT‐P13 treatment, and response rate achieving an absolute PASI score <1 was 55% at 30 weeks. The response rate was high (78%) in patients with psoriatic arthritis, and 40% and 20% in those in plaque psoriasis and pustular psoriasis, respectively. Of patients switched from IFX to CT‐P13 mainly for nonmedical reasons (n = 105), 57% had already reached PASI <1 by pretreatment with IFX and CT‐P13 maintained this status. The incidence of ADRs in this patient group was low and the drug survival rate was as high as 74%, even at 1 year, which was significantly higher than that in the naïve patient group (47%). Patients switched from other biologics for medical reasons (n = 16) responded similarly to biologic‐naïve patients, but drug survival was lower (24%). In conclusion, CT‐P13 showed excellent effectiveness as a first‐line therapy, no clinical difficulties in switching from IFX, and usefulness in patients who failed other biologics. CT‐P13 could be a cost‐effective alternative to IFX for the treatment of psoriasis.
Response of potential activity, abundance and community composition of nitrite‐dependent anaerobic methanotrophs to long‐term fertilization in paddy soils
Authors: Yang Yuling , Shen Lidong , Bai Yanan , Zhao Xu , Wang Shuwei , Liu Jiaqi , Liu Xin , Tian Maohui , Yang Wangting , Jin Jinghao , Huang Hechen , Wu Hongsheng
Published: July 2022

The process of nitrite‐dependent anaerobic methane oxidation (n‐damo) catalysed by Candidatus Methylomirabilis oxyfera (M. oxyfera)‐like bacteria is a novel pathway in regulating methane (CH4) emissions from paddy fields. Nitrogen fertilization is essential to improve rice yields and soil fertility; however, its effect on the n‐damo process is largely unknown. Here, the potential n‐damo activity, abundance and community composition of M. oxyfera‐like bacteria were investigated in paddy fields under three long‐term (32 years) fertilization treatments, i.e. unfertilized control (CK), chemical fertilization (NPK) and straw incorporation with chemical fertilization (SNPK). Relative to the CK, both NPK and SNPK treatments significantly (p < 0.05) increased the potential n‐damo activity (88%–110%) and the abundance (52%–105%) of M. oxyfera‐like bacteria. The variation of soil organic carbon (OrgC) content and inorganic nitrogen content caused by the input of chemical fertilizers and straw returning were identified as the key factors affecting the potential n‐damo activity and the abundance of M. oxyfera‐like bacteria. However, the community composition and diversity of M. oxyfera‐like bacteria did not change significantly by the input of fertilizers. Overall, our results provide the first evidence that long‐term fertilization greatly stimulates the n‐damo process, indicating its active role in controlling CH4 emissions from paddy fields.
Intégration – commerciale, budgétaire, financière – régionale et inégalités de revenu dans la Communauté Economique des Etats de l'Afrique de l'Ouest (CEDEAO)
Authors: Kebalo Léleng , Dout Hamitande , Couchoro Mawuli K. , Zouri Stéphane
Published: July 2022

Cet article vise à mettre en lumière l'effet de l'intégration économique régionale sur les inégalités de revenu dans la Communauté Economique des Etats de l'Afrique de l'Ouest (CEDEAO). En se fondant sur la méthode des moments généralisés (MMG) en panel dynamique, nous analysons les effets de trois composantes différentes de l'intégration économique régionale – intégration commerciale, budgétaire et financière – sur les inégalités de revenu dans la CEDEAO. L'étude couvre la période 1990–2018. Notre analyse empirique montre (i) une persistance des inégalités de revenu, (ii) une absence totale d'effet de l'intégration financière régionale sur les inégalités de revenu et (iii) des effets réducteurs de l'intégration commerciale et budgétaire sur les inégalités de revenu dans la CEDEAO qui varient selon l'appartenance ou non d'un pays à une union monétaire et selon leur niveau de revenu. L'article fait des propositions de politiques économiques dont l'application permettrait de réduire ces inégalités dans la CEDEAO.
Mapping employee involvement and participation in institutional context: Mick Marchington's applied pluralist contributions to human resource management research methods, theory and policy
Authors: Dundon Tony , Wilkinson Adrian , Ackers Peter
Published: July 2022

Our paper examines how the work of Mick Marchington integrated older forms of employee participation with newer patterns of employee involvement. The paper shows how Employee Involvement and Participation (EIP) is central to contemporary Human Resource Management (HRM) in four distinct ways: first is the ‘theoretical’ integration of pluralism into newer HRM approaches; second is the ‘practical’ insights gained from what was happening at organisational level; third is the contributions to ongoing ‘policy debates’ about fair work; and finally, his emphasis on ‘context‐sensitive methods’ link macro, meso and micro developments. We refer to three specific projects and related periods: a Department of Employment funded project during the late 1980s and early 1990s which developed the waves and escalator concepts of EIP; a Chartered Institute of Personnel Development project concerned with employee voice and management choice in the 2000s, which gave insight to multiple meanings of EIP and strategic choice; and research concerned with the notion of fair voice from comparative cases studies across different liberal market economies from 2008 onwards. By reflecting on these research projects and periods we present a potential framework that offers continued longevity for the future study of HRM.
A partial reduction of VDAC1 enhances mitophagy, autophagy, synaptic activities in a transgenic Tau mouse model
Authors: Vijayan Murali , Alvir Rainier Vladlen , Alvir Razelle Veronique , Bunquin Lloyd E. , Pradeepkiran Jangampalli Adi , Reddy P. Hemachandra
Published: July 2022

Alzheimer's disease (AD) is the most common cause of mental dementia in the aged population. AD is characterized by the progressive decline of memory and multiple cognitive functions, and changes in behavior and personality. Recent research has revealed age‐dependent increased levels of VDAC1 in postmortem AD brains and cerebral cortices of APP, APPxPS1, and 3xAD.Tg mice. Further, we found abnormal interaction between VDAC1 and P‐Tau in the AD brains, leading to mitochondrial structural and functional defects. Our current study aimed to understand the impact of a partial reduction of voltage‐dependent anion channel 1 (VDAC1) protein on mitophagy/autophagy, mitochondrial and synaptic activities, and behavior changes in transgenic TAU mice in Alzheimer's disease. To determine if a partial reduction of VDAC1 reduces mitochondrial and synaptic toxicities in transgenic Tau (P301L) mice, we crossed heterozygote VDAC1 knockout (VDAC1+/−) mice with TAU mice and generated double mutant (VDAC1+/−/TAU) mice. We assessed phenotypic behavior, protein levels of mitophagy, autophagy, synaptic, other key proteins, mitochondrial morphology, and dendritic spines in TAU mice relative to double mutant mice. Partial reduction of VDAC1 rescued the TAU‐induced behavioral impairments such as motor coordination and exploratory behavioral changes, and learning and spatial memory impairments in VDAC1+/−/TAU mice. Protein levels of mitophagy, autophagy, and synaptic proteins were significantly increased in double mutant mice compared with TAU mice. In addition, dendritic spines were significantly increased; the mitochondrial number was significantly reduced, and mitochondrial length was increased in double mutant mice. Based on these observations, we conclude that reduced VDAC1 is beneficial in symptomatic‐transgenic TAU mice.
You can't reason with them: Dismissing religious defectors as irrational
Authors: Elnakouri Abdo , McGregor Ian
Published: July 2022

Millions of people leave their religion every year. Such defection often results in religious persecution, ostracism, and heightened intergroup conflict. Yet little is known about the underlying perceptions of religious defectors and what intergroup processes predict hostility toward them. In two pre‐registered studies (N = 512), we investigated how religious group members' thoughts and feelings about defectors may lead to ostracism and a lack of dialogue. In both studies, group members rated defectors as unlikeable and irrational. Further, the strength of group members' religious group identification (but not religious belief conviction) predicted dislike and unwillingness to relate wisely with defectors (Study 2). Implications for intergroup research and improving the experience of religious defectors are discussed.
Latent class analysis of health, social, and behavioral profiles associated with psychological distress among pregnant and postpartum women during the COVID‐19 pandemic in the United States
Authors: Goldstein Ellen , Brown Roger L. , Lennon Robert P. , Zgierska Aleksandra E.
Published: July 2022

Background

There is a growing body of literature documenting negative mental health impacts from the COVID‐19 pandemic. The purpose of this study was to identify risk and protective factors associated with mental health and well‐being among pregnant and postpartum women during the pandemic.

Methods

This was a cross‐sectional, anonymous online survey study distributed to pregnant and postpartum (within 6 months) women identified through electronic health records from two large healthcare systems in the Northeastern and Midwestern United States. Survey questions explored perinatal and postpartum experiences related to the pandemic, including social support, coping, and health care needs and access. Latent class analysis was performed to identify classes among 13 distinct health, social, and behavioral variables. Outcomes of depression, anxiety, and stress were examined using propensity‐weighted regression modeling.

Results

Fit indices demonstrated a three‐class solution as the best fitting model. Respondents (N = 616) from both regions comprised three classes, which significantly differed on sleep‐ and exercise‐related health, social behaviors, and mental health: Higher Psychological Distress (31.8%), Moderate Psychological Distress (49.8%), and Lower Psychological Distress (18.4%). The largest discriminatory issue was support from one's social network. Significant differences in depression, anxiety, and stress severity scores were observed across these three classes. Reported need for mental health services was greater than reported access.

Conclusions

Mental health outcomes were largely predicted by the lack or presence of social support, which can inform public health decisions and measures to buffer the psychological impact of ongoing waves of the COVID‐19 pandemic on pregnant and postpartum women. Targeted early intervention among those in higher distress categories may help improve maternal and child health.
Income‐ and education‐based inequalities of edentulism and dental services utilization in Brazil
Authors: Ferreira Raquel Conceição , Souza João Gabriel Silva , Soares Anna Rachel dos Santos , Vieira Renato Vitor , Kawachi Ichiro
Published: July 2022

Objective

Tooth loss is a worldwide public health problem affecting mainly socioeconomically disadvantaged groups. Dental services utilization may increase access to preventive actions and conservative treatment, reducing the prevalence of tooth loss. This study evaluated the income‐ and education‐based inequalities in edentulism according to the utilization of dental services among adults and older adults in Brazil.

Methods

Data from the National Oral Health Survey (SB Brazil, 2010) of adults (ages 35–44 years, n = 9779) and older adults (ages 65–74 years, n = 7619) were analysed. Socioeconomic indicators (SES) included education and income. The magnitude of inequality in edentulism by education and income levels was estimated by the Relative Index of Inequality (RII) and the Slope Index of Inequality (SII). The changes in the RII and SII according to the utilization of dental services were estimated. Regression models estimated the association between SES and edentulism and whether dental services utilization modified this association.

Results

Higher edentulism prevalence was observed among those with lower education and income levels. The utilization of dental services changed the education‐based inequality index in edentulism for adults, with percentage changes of 17.4% (RII) and 56.8% (SII). For adults with low education (0–4 years of study), the odds of edentulism were 80% (OR 0.2; 95% CI 0.1–0.6) and 90% (OR 0.1; 95% CI 0.01–0.2) lower for those who had used dental services within the preceding year and within 1–2 years compared with those who had used such services within the preceding 3 or more years, respectively.

Conclusion

There was a social gradient in the prevalence of edentulism in adults and older adults, and the education‐based inequalities in edentulism were lower among adults reporting utilization of dental services in the preceding year.
Health‐related quality of life and psychological indicators of thriving 15–19 years after heart or lung transplantation
Authors: Dew Mary Amanda , DiMartini Andrea F. , Posluszny Donna M. , Myaskovsky Larissa , Switzer Galen E. , Puttarajappa Chethan , Hickey Gavin W. , Sanchez Pablo G. , DeVito Dabbs Annette J.
Published: July 2022

Background

Survival into the second decade after cardiothoracic transplantation (CTX) is no longer uncommon. Few data exist on any health‐related quality of life (HRQOL) impairments survivors face, or whether they may even experience positive psychological outcomes indicative of “thriving” (e.g., personal growth). We provide such data in a long‐term survivor cohort.

Methods

Among 304 patients prospectively studied across the first 2 years post‐CTX, we re‐interviewed patients ≥15 years post‐CTX. We (a) examined levels of HRQOL and positive psychological outcomes (posttraumatic growth related to CTX, purpose in life, life satisfaction) at follow‐up, (b) evaluated change since transplant with mixed‐effects models, and (c) identified psychosocial and clinical correlates of study outcomes with multivariable regression.

Results

Of 77 survivors, 64 (83%) were assessed (35 heart, 29 lung recipients; 15–19 years post‐CTX). Physical HRQOL was poorer than the general population norm and earlier post‐transplant levels (P’s < .001). Mental HRQOL exceeded the norm (P < .001), with little temporal change (P = .070). Mean positive psychological outcome scores exceeded scales’ midpoints at follow‐up. Life satisfaction, assessed longitudinally, declined over time (P < .001) but remained similar to the norm at follow‐up. Recent hospitalization and dyspnea increased patients’ likelihood of poor physical HRQOL at follow‐up (P's≤ .022). Lower sense of mastery and poorer caregiver support lessened patients’ likelihood of positive psychological outcomes (P’s ≤ .049). Medical comorbidities and type of CTX were not associated with study outcomes at follow‐up.

Conclusions

Despite physical HRQOL impairment, long‐term CTX survivors otherwise showed favorable outcomes. Clinical attention to correlates of HRQOL and positive psychological outcomes may help maximize survivors’ well‐being.