bluuebunny/crossref_metadata_2025 huggingface dataset:
Competências desenvolvidas no processo de formação profissional dos técnicos de enfermagem da região sul do Rio Grande do Sul
Authors: Silva Carla Regina Andre , Righi Deise Lima , Pelzer Marlene Teda
Published: July 2021

Estudo desenvolvido nos cursos Técnicos de Enfermagem da região sul do estado do Rio Grande do Sul, objetivando analisar o processo de formação profissional formal dos futuros técnicos em enfermagem, nesta localidade, se faz por meio do desenvolvimento de competências, assim como conhecer as competências que estão sendo desenvolvidas nestes cursos. O significado sobre desenvolvimento de competências no âmbito educacional e profissional está alicerçado nas ideias de Philippe Perrenoud. A metodologia é uma abordagem qualitativa, de natureza exploratória e caráter descritivo. A coleta dos dados primários foi mediada pela aplicação de instrumento semiestruturado, com perguntas abertas e fechadas, aos discentes e docentes, no segundo semestre de 2018. E os dados secundários foram obtidos através de pesquisa documental. O estudo foi desenvolvido em quatro instituições distribuídas em três municípios, participando 64 discentes e cinco docentes. Os resultados foram extraídos com base no método de análise de conteúdo. Foram encontrados elementos constitutivos que indicam que o processo formativo nestes espaços está alicerçado nas noções de competências de acordo com referencial teórico adotado. Assim, o processo de ensino aprendizagem ao contemplar o desenvolvimento de competências, adquire um sentido mais amplo do que apenas a formação profissional e inserção no mercado de trabalho. Tem como possibilidades a contribuição com a produção de saúde individual, coletiva e pública e formação humana e cidadã de seus integrantes.
The integrative model for the semantic space of music and a contemporary musical educational process: the scientific and creative heritage of Mikhail Borisovich Ignatyev
Authors: Gorbunova Irina
Published: July 2021

The advent of computer technology has led to the creation and development of new forms of teaching musical art. The emergence of music computer technologies (MCT) was the basis for creating both new forms in the educational process and new subjects, the appearance of new disciplines and new educational trends in the system of a contemporary musical education. These new subjects, such as “Musical Informatics,” “Computer Music Creative Work,” “Computer Arrangement and Composition, Sound and Timbre Programming,” “Electronic Musical Instruments” and many others, fully reflect the essence of the changes that have occurred in approaches to the study of music art. This article analyzes the possibility of including an integrative model for the semantic space of music, developed with the participation of the prominent cybernetics, scientist Mikhail Borisovich Ignatyev, in a contemporary musical educational process.
The Jewish wall: The Eisenman empire
Authors: Rizzi Renato
Published: July 2021

In this article author is arguing that architecture, like all other aesthetic disciplines, has for long been pointing to the original problem: the sense of form. The form is seen as the multiplicity of expressive language that comes from particular kind of knowledge. Regarding this architecture is seen as work of realization; the cognition of knowledge and that the form is representation, the sense is the essence. Author is also arguing that the greater variable, although not the only one, among the four factors concerns the right to knowledge. The greater or smaller its extension and profoundness, the greater or smaller our ability to slide along the essential line of the slope. Or, towards the "contents of the truth of one work", if we wish to use the same words of Walter Benjamin. But the hypothesis, although it has to be demonstrated yet, imposes the logic of thoughts, which should be added to the aesthetics of thoughts: the gift of compilation, the image of the unity of the entirety. In several parts of this paper, through the questions of the theological, the scene of thought, interpretation on representation and contemplation, ideas, concepts and phenomenon, author will discuss on possible interpretations of work of Pieter Eisenman.
NÚCLEO EXTENSIONISTA RONDON – NER/UDESC
Authors: Deggeroni Maicon Vinicius Ritter , Bertelli Valmir , Balduíno Santos Alfredo , Márcia Marques Santos Vera
Published: July 2021

Esse artigo traz um breve relato sobre o Núcleo Extensionista Rondon – NER/UDESC, sua atuação no Estado de Santa Catarina, no Brasil e no exterior, sua estruturação e experiências, desde a sua criação, por meio de práticas extensionistas por onde as Operações do NER/UDESC  se fizeram presentes. O texto aborda a indissociabilidade entre Ensino, Pesquisa e Extensão como prática referência das ações do núcleo, aproximando o desenvolvimento acadêmico, pessoal e profissional dos extensionistas participantes. A partir das intervenções do NER/UDESC, observa-se a relevância das atividades extensionistas desenvolvidas, considerando-se a formação acadêmica pautada nas diretrizes acadêmicas e pedagógicas expressas nas oito áreas da Extensão Universitária.
EXPERIÊNCIAS NEABIANAS NO NÚCLEO EXTENSIONISTA RONDON
Authors: Rascke Karla Leandro , Lima Graziela dos Santos , Moraes Janine Soares R. , Lopes Ana
Published: July 2021

O trabalho pretende apresentar as experiências de ex-bolsistas e bolsista do Núcleo de Estudos Afro-Brasileiros-NEAB/UDESC em atividades extensionistas em diferentes operações no Núcleo Extensionista Rondon, nos anos 2011, 2013, 2018 e 2019. Objetivamos refletir sobre nossa percepção em relação às ações de extensão no âmbito universitário, as quais participamos, e relacioná-las com as oficinas realizadas no NER/UDESC. Dessa forma, refletir sobre as ações NEABianas relacionadas aos trabalhos que diz respeito à equidade racial e à visibilidade das culturas africanas e afro-brasileira, conforme a Lei Federal 10.639/03, em conformidade com as Diretrizes Curriculares Nacionais para a Educação das Relações Étnico-raciais e para o Ensino de História e Cultura Afro-Brasileira e Africana (2004), enfatizando a importância destas ações na região de execução da Operação NER/UDESC. Nossa metodologia neste texto pauta-se numa reflexão crítica sobre as experiências vivenciadas pelas participantes nas operações indicadas. Os principais resultados e conclusões dizem respeito ao entendimento de que a extensão universitária é uma potente forma de construir e consolidar políticas públicas de democratização do conhecimento nas IES brasileiras, bem como da promoção da igualdade racial.
Interrogating disability and prosthesis through the conceptual framework of NEODISABILITY
Authors: Fristrup Tine , Odgaard Christopher Karanja
Published: July 2021

This article investigates the emerging field of critical disability studies in order to explore understandings of disability and prosthesis through the intersection of dis/ability studies, studies in ableism, and philosophical enquiries into the biopolitics of disability and neoliberal psychopolitics. We present the interpretation that contemporary Western ableism is confi gured by neoliberal arrangements operating on the individual in ongoing processes of self-improvement. People who fail in the achievement society see themselves as being responsible for their own situation, blaming themselves as individuals instead of questioning the ableism that organises contemporary societal orderings in the neoliberal production of inferiority. We offer a conceptual framework of neodisability by unfolding internalised disabling processes in which the bifurcation of ‘dis’ and ‘ability’ operates through the forward-slash in dis/ability. The forward-slash captivates the optimistic cruelty in the workings of contemporary ableism in search of excellence through prosthetic confi gurations in an achievement economy: desiring the invisible prosthesis of willpower in the constant pursuit of overcoming the ‘dis/’. Neodisability engenders contemporary psycho-neoliberal-ableism, with people turning their aggressions against themselves in never-ending processes of dis-ing parts of themselves as ‘notfit-enough’, while being in constant need of therapeutic interventions to employ and promote the self-optimising efforts in times of neodisableism.
Gendering of Objectivity and Resistance to Feminist Knowledge
Authors: Lodahl Mads Ananda , Skewes Lea
Published: July 2021

Editorial note:In our interview with Anne Fausto-Sterling and Julie Nelson, ”The Gendering of Objectivity and Resistance to Feminist Knowledge”, we would like to correct an error on Anne Fausto-Sterling’s request. In the discussion about Hubert Humphrey, it was not he who spoke about women leaders, but his physician – the white House doctor.
The Management of Foreign Body Sensation in the Throat after Stroke by Trigger Point Injection on Posterior Belly of Digastric Muscles
Authors: Kim Howard , Yang Hoe Saeng , Cheon Ji Hwan , Won Ki Hong
Published: July 2021

Foreign body (FB) sensation in the throat is often a common symptom encountered in clinical practice. FB sensation in throat has numerous causes mainly caused by reflex diseases such as laryngopharyngeal reflux. Its treatment has been focused on organic problems or hysteria while musculoskeletal problem has been neglected. We hereby report a patient with dysphagia and complaint of FB sensation in the throat after nasogastric tube removal. It was relieved by trigger point injection on the posterior belly of digastric muscles.
La crise anglophone : entre lutte de reconnaissance, mouvements protestataires et renégociation du projet hégémonique de l’État au Cameroun
Authors: Keutcheu Joseph
Published: July 2021

La crise anglophone, en fait le mouvement social actuel dans les régions anglophones du Nord-Ouest et du Sud-Ouest du Cameroun, est loin d’être une génération spontanée. Elle est le produit d’une histoire singulière de la rencontre entre deux parties d’un même pays ayant subi une double colonisation (anglaise et française) et d’une conjoncture tout aussi particulière qui amène les acteurs à réinventer une cause anglophone ancienne. La présente étude montre qu’elle plonge ses racines dans le malaise identitaire non soldé du lendemain des indépendances, malaise qui a produit la longue lutte de reconnaissance des Anglophones. Les interactions entre les acteurs de la mobilisation anglophone actuelle permettent de mettre en évidence les signes de la renégociation d’un nouveau rapport à l’ordre politique au Cameroun. Il s’agit d’une négociation désormais expurgée de sérénité qui donne à voir un épuisement au moins provisoire du référentiel monopoliste de l’État camerounais.
Humour et vivre ensemble : stéréotypes identitaires au sein des groupes minoritaire et majoritaire québécois
Authors: Choquette Emmanuel
Published: July 2021

La présente étude aborde l’humour comme un véritable outil de reconnaissance identitaire, lequel, bien qu’ayant des effets ambivalents, contribue à déterminer la perception et la compréhension des différents particularismes sociétaux. Par ailleurs, la relation entre l’humour et les enjeux entourant le vivre ensemble a été peu abordée en science politique. En ce sens, le principal objectif de la présente recherche vise à observer comment les humoristes québécois traitent des questions entourant la diversité ethnique, culturelle et religieuse. À travers une analyse de contenu qualitative et quantitative, la recherche compte répondre à trois questions spécifiques. La première vise à identifier les différentes communautés dont il est question au sein des numéros analysés. La seconde a pour but de souligner les principaux stéréotypes entretenus par les humoristes à l’égard des différentes communautés ciblées. Enfin, la troisième question vient mettre en lumière comment, entre groupe majoritaire et groupe minoritaire, on parle de ces communautés. Afin de mener à terme cette recherche, on a procédé à l’analyse de 76 vidéos humoristiques répertoriées sur YouTube, réalisées entre 2006 et 2018 au Québec et traitant de diversité ethnique, culturelle et religieuse. On constate que les Arabo-musulmans s’avèrent la principale cible des humoristes durant cette période. Le stéréotype liant islam et terrorisme demeure également souligné de façon récurrente. Il semble enfin que la communauté arabo-musulmane représente une cible de choix pour une majorité d’humoristes, qu’ils proviennent du groupe majoritaire ou du groupe minoritaire.
Innovation parlementaire, entrepreneuriat et déserts médicaux en France
Authors: Moncada Marie
Published: July 2021

Le Parlement français est oublié des abondants travaux sur les « déserts médicaux ». Pourtant, sur ce sujet, de nombreux parlementaires vont à contre-courant des programmes présidentiels, de l’administration et des groupes d’intérêt et prennent ouvertement la défense de mesures contraignantes. Cette innovation parlementaire soulève la question suivante : les parlementaires français sont-ils des entrepreneurs d’action publique ? L’analyse est faite sur les archives parlementaires de 1998 à 2019. L’analyse qualitative montre bien l’existence d’une innovation parlementaire en faveur des mesures contraignantes. L’analyse quantitative pour sa part répond par la négative à la problématique : les parlementaires ne sont pas des entrepreneurs en raison de leur subordination volontaire à l’exécutif et aux groupes d’intérêt médicaux.
‘Screenshotting’, o la expresión artística a través de los videojuegos
Authors: Cernadas Romero Francisco-Ramón
Published: July 2021

Este artículo pretende dar a conocer el mundo de la fotografía dentro de los videojuegos, una disciplina artística prácticamente desconocida para la gran mayoría, pero que consigue poner rostro (aunque virtual) a todo un conjunto de herramientas, técnicas y experiencias artísticas gestadas dentro de nuestros dispositivos electrónicos.
History of Pandemics in the Twentieth and Twenty-First Century
Authors: Falode Adewunmi J. , Yakubu Moses J. , Bolarinwa Olusegun J.
Published: July 2021

This work is the historical analysis of pandemics in the Twentieth and Twenty-first century. It shows that the influenza virus has been responsible for major pandemic outbreaks in the two centuries. The work shows that bacteria and viruses, especially Yersinia pestis and the influenza virus, have been responsible for the outbreaks of major pandemics in recorded history. It carries-out a compre- hensive and extensive analysis of the various impacts of historical and contemporary pandemics like the Plague of Justinian, Bu- bonic plague, Spanish flu, Cholera pandemics and also the novel COVID-19 had on the trajectory of world history. The work shows that such pandemics profoundly affects political, economic, social, religious, technological, health and educational developments in states in the post-pandemic periods. Additionally, this work com- prehensively identified the commonalities among the pandem- ic-causing diseases in the Twentieth and Twenty-first century. It shows, among other things, that pandemic-causing diseases usu- ally strikes in waves and that globalization plays an active role in the transmission of infection in the two centuries. The work concludes by showing that pandemics usually strikes in three waves and based on this assertion the world should be prepared to respond to the second and third waves of the COVID-19.
Aktuelnost Fihteovog poimanja transcendentalnog Ja i psihološkog Ja za savremenu filozofiju duha (II deo)
Authors: Jurić Andrija
Published: July 2021

Autor u radu ukazuje na bitnost osnovnih Fihteovih ideja iz učenja o nauci za savremenu filozofiju duha, kao i na problem određenja svesti i samosvesti. Egologija učenja o nauci vidi Ja istovremeno kao čisto, transcendentalno i logičko, a opet i kao konkretno i indi- vidualno. Time se otvara problematika odnosa Ja i svesti, izražena egološkim i neegološkim shvatanjima, koja igraju bitnu ulogu i u savremenoj filozofiji duha. Prema Fihteovom originalnom uvidu, nemoguće je objasniti samosvest putem predmetne (intencional- ne) svesti – već ju je neophodno konceptualizovati kao sui generis modus svesti u vlastitoj neposrednoj usmerenosti na samu sebe. Ovo shvatanje omogućava da se samosvest više ne objašnjava re- fleksijom, čime se otvara problematika prirode samoodnosa svesti i izvornog dupliciteta sadržanog u njemu, a s druge strane, ukazuje se na ulogu Ja u pre-refleksivnoj (samo)svesti.
Effects of different biomass materials as a salt-isolation layer on water and salt migration in coastal saline soil
Authors: Yang Mao , Yang Runya , Li Yanni , Pan Yinghua , Sun Junna , Zhang Zhenhua
Published: July 2021

The aim of this study was to find a material suited for the prevention of evaporative water loss and salt accumulation in coastal saline soils. One-dimensional vertical water infiltration and phreatic evaporation experiments were conducted using a silty loam saline soil. A 3-cm-thick layer of corn straw, biochar, and peat was buried at the soil depth of 20 cm, and a 6-cm-thick layer of peat was also buried at the same soil depth for comparison. The presence of the biochar layer increased the upper soil water content, but its ability to inhibit salt accumulation was poor, leading to a high salt concentration in the surface soil. The 3-cm-thick straw and 6-cm-thick peat layers were most effective to inhibit salt accumulation, which reduced the upper soil salt concentration by 96% and 93%, respectively. However, the straw layer strongly inhibited phreatic evaporation and resulted in low water content in the upper soil layer. Compared with the straw layer, the peat layer increased the upper soil water content. Thus, burying a 6-cm-thick peat layer in the coastal saline soil is the optimal strategy to retain water in the upper soil layer and intercept salt in the deeper soil layer.
Legal Review of the Expansion of the Scope of Work for 119 Emergency Medical Services (EMS) Personnel
Authors: Lim Jae-Man
Published: July 2021

Emergency services by fire-fighting agencies are an important subject of study. As 119 EMS personnel provide first aid to patients and transfer them to emergency room, the first aid they render involves medical practice and therefore requires research from a legal point of view. This study is based on current laws (as of Feb 2021) and an analysis and review of rulings of the Constitutional Court and the Supreme Court, as well as data from the National Fire Agency’s Statistical Yearbook. Fire-fighting agencies hire and assigned individuals who hold the requisite certificate, and the legitimacy of medical practice by 119 EMS personnel is based on the qualifications they hold, not their status as fire officials, as per the EMERGENCY MEDICAL SERVICE ACT. If their scope of work is expanded by the revision of the ACT ON 119 RESCUE AND EMERGENCY MEDICAL SERVICES, their medical practice is justified based on the combination of their qualifications and status (fire officials).
MACHINE LEARNING APPLICATION AS THE BASIS OF AN EXPERT SYSTEM FOR ACHIMOV DEPOSITS IN WESTERN SIBERIA
Authors: Timirgalin A.A. , Meshcheryakova A.S. , Sevostyanov A.I. , Minich A.A. , Makarevich E.V. , Volkov G.V. , Mukminov I.R. , Metelkin D.V. , Kondratyev A.Yu.
Published: July 2021

Achimov formation deposits are a perspective source of reserves replenishing and maintaining production. The objects associated with these deposits have an extremely complex structure and high heterogeneity both in plan and in section. Some experience in study and development of Achimov deposits is collected. Effective study and development of such objects as the Achimov formation requires an individual technological and methodological approach. From the point of view of the research methodology, the most rational and comprehensive approach is the system analysis approach, the essence of which is to isolate and study the properties of geological body systems, the components of which have certain structural and genetic relationships. Already at the early stages of exploration, in conditions of lack of information, it is necessary to have a complete understanding of the object structure geological features, affecting the further development and economics of projects. In addition, for the qualitative compilation of research programs, reliable prediction of the objects properties and optimal development strategy and method selection, a consistent systematization and intellectual analysis of the available information are required. This can be achieved by creating an expert system that allows to integrate knowledge and experience about the target object at all levels, conduct intellectual processing of the available incomplete and often inaccurate information, offer analogues and technological solutions using machine learning and data analysis algorithms. The basis of the expert system is the knowledge base. In this paper, we consider the use of machine learning in creating a knowledge base as its basis.
LAB EXPERIMENTS DESIGN FOR GAS EOR PROJECTS
Authors: Vershinina M.V. , Penigin A.V. , Glavnov N.G. , Mukhametzyanov I.Z. , Сергеев Е.И.
Published: July 2021

ВThe application of miscible displacement technology is associated with significant risks and uncertainties. Therefore, it is important to plan a lab programme carefully with the aim of mitigation or eradication of those risks at the design stage. This stage conventionally includes lab analysis, pilot projects, simulations, an analysis of and interactions with potential technology suppliers, etc. This article presents an overview of an adequately detailed laboratory research programme required to apply miscible displacement, and also highlights the important aspects of each experiment that deserve consideration.
OPTIMIZATION OF INTEGRATED PRODUCTION MODEL CALCULATIONS
Authors: Senkin I.S. , Akmadieva L.I.. , Belonogov E.V.
Published: July 2021

The article discusses a new technique for optimizing the calculations of the integrated model, all stages of the calculations are analyzed. The analysis of the necessary input data for the integrated model is carried out and the definition of the calculation results according to the obtained method is given. Comparison of calculations using the developed method and a commercial package is obtained. Opportunities for applying the obtained solution are proposed.
OPERATIONAL FEATURES AND METHODS FOR DETERMINING THE OPTIMAL OPERATION PARAMETERS IN FRACTURED RESERVOIRS WITH A GAS CAP: OIL RIMS OF ORENBURG OGCF CASE STUDY
Authors: Yudin E.V. , Piotrovskiy G.A. , Kolyuk O.A. , Smirnov N.A. , Galyautdinov I.M. , Sagirov A.A. , Lomukhin I.A.
Published: July 2021

The paper deals with the features of well operation at the Eastern part of Orenburg oil and gas condensate field (OGCF). We propose a complex approach to determining the parameters of the fractured formation: based on the mathematical model of Warren–Root fracture reservoir, we find the dependence of the well flow rate on time and parameters of fracture under conditions of maintaining constant bottomhole pressure. Next stage is an extrapolation of this problem for the case of arbitrary dynamics of flow rates and pressures based on the deconvolution theory. The search of parameters of double fracture formation is carried out by their variation in the corridor of admissible values in order to minimize the deviation of the calculated flow rate relative to the true one. To identify possible reasons for the decline in well productivity with a decrease in bottomhole pressure, numerical experiments were performed on synthetic hydrodynamic models to determine the main influencing factors that can lead to an observed decrease in well productivity with increasing depression. Based on the information received, multivariate calculations of sector models of the EP OGCF were carried out in order to determine the optimal operating parameters to maximize oil production or minimize specific operating costs, taking into account the identified complicating factors.
APPLICATION OF SUPERBLOCKS FOR INCREASING EFFICIENCY OF PROJECT IMPLEMENTATION
Authors: Trifonov A.V. , Volodkin M.S. , Poltavskiy D.N..
Published: July 2021

The works associated with the construction of infrastructure facilities in the field require significant involvement of highly qualified specialists, high-quality implementation of these works and it requires adjustment of the developed project documentation directly in the construction process. PJSC «Gazprom neft» is faced with the task of increasing the efficiency of capital projects, in particular, reducing the time for their implementation. The faster the field is equipped and ready to start production, the sooner the capital investment in the project will pay off. The article discusses the method of organizing the construction (arrangement) using block-complete devices, namely one of its methods – superblocks. The essence of the method is the manufacture in the factory of modules, enlarged mounting assemblies, instrumentation and automation devices and their subsequent enlarged assembly into a large-capacity unit (superblock). The mass of the superblock can reach up to 1000 tons. The use of superblocks in the development of oil and gas fields guarantees high productivity, time saving and the quality of the facilities being built.
THE GROUPING OF PLANNED WELLS FOR WELL PADS LOCATION BY MULTI-LAYER FIELD
Authors: Shatrovskiy A.G. , Chinarov A.S , Salikhov M.R
Published: July 2021

An approach to improving the project quality of a multi-layer field development, which allows to bring the project to the real conditions of the field development, to reduce its capital intensity is proposed. The key task is to find the optimal pads distribution pattern based on the development system of target operational facilities, which ensures the formation of development elements at dependent production facilities at the expense of transit wells. This takes into account the purpose and mode of wells operation. This arrangement of well pads should ensure minimal capital costs and technological risks in the implementation of the project due to multi-factor optimization. For this purpose, length and complexity of trajectory wells, infrastructure, natural and environmental restrictions on the field territory, technical restrictions in wells construction are taken into account. Such problem for multi-layer field is not solved by existing software systems. A method of grouping the project drilling targets, as a stage of well pads distribution, based on modified clustering method k-means is considered. The clustering algorithm is adapted to minimize the total penetration of inclined and horizontal wells, taking into account the complexity of their trajectories.
SUBSTANTIATION OF THE SPECIFIC CRITERION FOR THE CORROSIVE EFFECT OF FORMATION MEDIA ON THE CYCLIC STRENGTH OF STEEL OF DOWNHOLE EQUIPMENT
Authors: Yushin E.S.
Published: July 2021

The article provides the substantiation of the specific coefficient of corrosion influence, considered per unit of the limit of short-term strength of the metal, with the help of which it is possible to simplify the most approximate calculation of the limited endurance limit of steels of oil and gas equipment operating under cyclic loads, as well as perform subsequent resource calculations.
DIGITAL CORE TECHNOLOGY APPLICATION AT SARQALA FIELD
Authors: Morozov V.V. , Melnikov S.I. , Idrisova S.A. , Savelev O.Yu. , Serebryanskaya A.U. , Bilinchuk A.V. , Zagrebelniy E.V.
Published: July 2021

An integrated laboratory study of low permeable carbonate reservoir (dolomitic limestones, Sarqala field) included a digital rock (DR) workflow that accelerated the time to complete the core analysis program, in a case when the standard is ineffective. All these data were used to justify the field development strategy.
CURRENT APPROACH TO ASSET EVALUATION AT THE SEARCH STAGE WITH HIGH UNCERTAINTIES
Authors: Balashov D.A , Viktorova E.M. , Zvada A.N. , Kiselev P.Yu.
Published: July 2021

New approach of complex uncertainties analysis at the exploration stage of the field is considered not only for geological properties but also for reservoir engineering, including the uncertainty of type of hydrocarbons saturation. The method shown in the work is based on the probabilistic method of HIIP estimation which is followed by probabilistic reservoir engineering uncertainties assessment in production profiles calculation.
DETERMINATION OF MOBILE WATER IN RESERVOIRS OF ACHIMOV THICKNESS
Authors: Mukhidinov S.V. , Belyakov E.O.
Published: July 2021

The rocks of the Achimov deposits are known for low porosity, permeability and poor connectivity of the pores. They belong to the Lower Cretaceous complex and have a complex geological structure. Oil and gas-bearing objects in the Achimov deposits belong to the non-anticlinal type of traps and are confined to clinoforms. The question of studying the volume of mobile water in the rocks of the Achimov is important, but is still open. The success of geological exploration and the risks of production drilling depend on the effectiveness of solving this problem.
REASONS OF DECREASING THE EFFICIENCY OF DEFLECTION TECHNOLOGIES IN WESTERN SIBERIA
Authors: Khoryushin V.Yu. , Groman A.A.
Published: July 2021

The paper considers the reasons for the decrease in the efficiency of deflection technologies in the fields of Western Siberia and proposes implements for control the negative effect.
PRODUCTION FORECAST FOR BAZHEN FORMATION RESERVOIRS ON THE BASIS OF STATISTICAL ANALYSES AND MACHINE LEARNING TECHNIQUES
Authors: Shevchuk T.N. , Kashnikov O.Yu. , Mezentseva M.A. , Baykov I.V. , Karimov T.S. , Gatin R.I. , Lomovitskiy P.V. , Korobitsyn D.A.
Published: July 2021

The paper reviews actual production results and production forecasting for horizontal wells completed using multistage hydraulic fracturing in Bazhenov formation of Palyan area, Krasnoleninskoye oilfield (HMAO). The key feature of these reservoirs is high degree of uncertainty in geological and geomechanical properties. The primary purpose of this study is to provide both identification of correlation between well productivity index (rates, cumulative production) and general geological-technological factors and software development for production forecasting of Bazhen formation wells. In the course of the works, more than 2000 probable correlations between geological and geomechanical formation properties as well as between technological factors and well performance have been analyzed. Main key complex parameters (length of horizontal section, number of frac stages, average tonnage of proppant and fracturing fluid back-production) that govern producing well performance have been determined in this analysis. The approach for evaluation of forecast well performance (initial rate, cumulative oil production) is provided on the basis of obtained statistical correlations and machine learning techniques. Approaches described in this paper summarize the first results of the phase «Select» in progress of pilot project on Palyan area, Krasnoleninskoye oilfield.
MTHFD2 promotes ovarian cancer growth and metastasis via activation of the STAT3 signaling pathway
Authors: Li Qiutong , Yang Fang , Shi Xiu , Bian Shimin , Shen Fangrong , Wu Yuhong , Zhu Chenjie , Fu Fengqing , Wang Juan , Zhou Jinhua , Chen Youguo
Published: July 2021

Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a bifunctional enzyme located in the mitochondria. MTHFD2 has been reported to be overexpressed in several malignant tumors and is implicated in cancer development. This study aimed to investigate the effect of MTHFD2 on ovarian cancer progression. The expression of MTHFD2 was detected by bioinformatic analysis, immunohistochemistry, RT‐qPCR (real‐time quantitative PCR analysis), and western blot analysis. The effects of MTHFD2 depletion on cell proliferation, migration, and invasion were determined through in vitro experiments. Cell cycle progression and apoptosis were accessed by flow cytometry. The related signaling pathway protein expression was determined by western blot analysis. We found that MTHFD2 is highly expressed in both ovarian cancer tissues and cell lines. MTHFD2 deletion suppressed cell proliferation and metastasis. Knockdown of MTHFD2 induces cell apoptosis and G2/M arrest, whereas the number of cells in S phase increased with MTHFD2 overexpression. Mechanically, our results indicate that an inhibitory effect of MTHFD2 knockdown may be mediated by the downregulation of cyclin B1/Cdc2 complex and the inhibitory effect on its activity. Additionally, MTHFD2 could regulate cell growth and aggressiveness via activation of STAT3 and the STAT3‐induced epithelial–mesenchymal transition signaling pathway. These findings indicate that MTHFD2 is overexpressed in ovarian cancer and regulates cell proliferation and metastasis, presenting an attractive therapeutic target.
Machine Learning‐Guided Design of Pearlitic Steel with Promising Mechanical and Tribological Properties
Authors: Qiao Ling , Zhu Jingchuan
Published: July 2021

Herein, attempts have been made to design and develop pearlitic steels for application in heavy‐haul rails. The hardness plays a vital role in studying the mechanical and tribological properties, which is theoretically related to the alloying composition of steel. With aid of machine learning (ML) method, the particle swarm optimization (PSO) improved generalized regression neural network (GRNN) is utilized to model the relationship between composition and hardness of pearlitic steel. The results show that the designed steel exhibits superior hardness and mechanical properties with fine pearlite lamellar microstructure. In addition, the wear behavior of the steel and its wear mechanism are systematically studied by tribological testing and electron probe microanalysis (EPMA) observations of worn surface and wear particles. With composition optimization, the wear resistance has further improved as evidenced by the lower friction coefficient and reduction of wear volume. The pearlitic steels exhibit a combined wear mechanism including adhesive wear, abrasion, delamination, and plastic deformation. As a result, the designed steels offer high hardness with very good mechanical and tribological properties which are far superior to previously reported pearlitic steels. This work may assist in developing the appropriate composition to create the desired hardness, mechanical, and tribological properties.
Iridium‐Catalyzed Enantioselective Allylic Substitutions of Racemic, Branched Trichloroacetimidates with Heteroatom Nucleophiles: Formation of Allylic C−O, C−N, and C−S Bonds
Authors: Arachchi Madhawee K. , Nguyen Hien M.
Published: July 2021

A broadly applicable methodology for the regio‐ and enantioselective construction of branched allylic carbon‐heteroatom bonds from racemic, secondary allylic trichloroacetimidates has been developed. The branched allylic substrates undergo dynamic kinetic asymmetric substitution reactions with a number of unactivated anilines and carboxylic acids as well as unactivated aromatic thiols in the presence of a chiral bicyclo[3.3.0]octadiene‐ligated iridium catalyst. The allylic C−O, C−N, and C−S bond containing products are obtained in synthetically useful yield and selectivity. Mechanistic studies suggest that the iridium‐catalyzed enantioselective substitution reactions of heteroatom nucleophiles with allylic trichloroacetimidate substrates through an outer‐sphere nucleophilic addition mechanism. In addition, the chiral diene‐ligated iridium catalyst is effective at promoting asymmetric aminations of acyclic secondary anilines. Importantly, this catalytic iridium methodology enables the use of alkyl substituted allylic electrophiles.

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A practical guide for conducting qualitative research in medical education: Part 2—Coding and thematic analysis
Authors: Coates Wendy C. , Jordan Jaime , Clarke Samuel O.
Published: July 2021

An organized and rigorous approach to analyzing qualitative data can yield important insights into the intricacies of human behavior and can answer “how” and “why” questions. One process of coding interview responses from study subjects using grounded theory with a constructivist approach is outlined and applied to an example study. The emergent themes can provide insight to medical educators to create interventions that optimize the learning environment. For researchers, they may generate hypotheses to study by quantitative analysis.
Development of a Cell‐Loading Microrobot with Simultaneously Improved Degradability and Mechanical Strength for Performing In Vivo Delivery Tasks
Authors: Wei Tanyong , Li Junyang , Zheng Liushuai , Wang Cheng , Li Feng , Tian Hua , Sun Dong
Published: July 2021

Microrobots with simultaneously improved degradability and mechanical strength are highly demanded in performing in vivo delivery tasks in clinical applications. The properties of degradability and mechanical strength are contradictory for many materials used to make microrobots. This article proposes a new design that can result in 3D cell culture microrobots with improved degradability and mechanical strength from the following perspectives. First, the mechanical strength of a microrobot is improved using triangle patterns to replace hexagon pattern in the microrobot structure, which can provide more supporting grids to obtain increased mechanical strength. Second, the relationship between structural design and material composition in relation to the mechanical strength of microrobot is investigated. The study reveals that triangle‐patterned microrobots have increased mechanical strength compared with hexagon‐patterned microrobots, thereby allowing high composition of degradable material that leads to the fast degradation of the microrobot. It is also shown that the triangle‐patterned microrobots can maintain the same structural integrity and cell capacity as hexagon‐patterned microrobots. Finally, the demonstration shows that the triangle‐patterned microrobot can be precisely navigated in microfluidic channels. This article successfully demonstrates that the degradability and mechanical strength can be improved simultaneously through the microrobot structural design.
Continuous reactor network design for multiple rigid polyol productions
Authors: Wen Yunhan , Biegler Lorenz T. , Ochoa Maria P. , Weston John , Nikbin Nima , Ferrio Jeff
Published: July 2021

This study focuses on developing continuous reactor network models able to produce multiple rigid polyol products under strict product and safety specifications. We first determine reactor networks and operating decisions for minimum capital cost, and then find reactor networks with optimal profit through multi‐criteria optimization, using a Pareto chart to analyze the relationship between capital cost and net sales. Based on our previous study, we narrow down the types of continuous reactors that can be part of the network to two: plug flow reactor (PFR) with multiple feed injection points and a network of continuous stirred tank reactors (CSTR). The CSTR model can be written as a mixed integer nonlinear programming (MINLP) problem. The PFR model is a differential algebraic equation (DAE) optimization problem. The simultaneous collocation method is applied to transform the resulting DAE model into an MINLP, which is solved as a NLP by fixing the binary terms. Both capital cost and multi‐criteria problems are formulated as multi‐scenario optimization problems to determine the best single network design to produce multiple polymer products.
Automated Annotation of Epileptiform Burden and Its Association with Outcomes
Authors: Zafar Sahar F. , Rosenthal Eric S. , Jing Jin , Ge Wendong , Tabaeizadeh Mohammad , Aboul Nour Hassan , Shoukat Maryum , Sun Haoqi , Javed Farrukh , Kassa Solomon , Edhi Muhammad , Bordbar Elahe , Gallagher Justin , Moura Valdery , Ghanta Manohar , Shao Yu‐Ping , An Sungtae , Sun Jimeng , Cole Andrew J. , Westover M. Brandon
Published: July 2021

Objective

This study was undertaken to determine the dose–response relation between epileptiform activity burden and outcomes in acutely ill patients.

Methods

A single center retrospective analysis was made of 1,967 neurologic, medical, and surgical patients who underwent >16 hours of continuous electroencephalography (EEG) between 2011 and 2017. We developed an artificial intelligence algorithm to annotate 11.02 terabytes of EEG and quantify epileptiform activity burden within 72 hours of recording. We evaluated burden (1) in the first 24 hours of recording, (2) in the 12‐hours epoch with highest burden (peak burden), and (3) cumulatively through the first 72 hours of monitoring. Machine learning was applied to estimate the effect of epileptiform burden on outcome. Outcome measure was discharge modified Rankin Scale, dichotomized as good (0–4) versus poor (5–6).

Results

Peak epileptiform burden was independently associated with poor outcomes (p < 0.0001). Other independent associations included age, Acute Physiology and Chronic Health Evaluation II score, seizure on presentation, and diagnosis of hypoxic–ischemic encephalopathy. Model calibration error was calculated across 3 strata based on the time interval between last EEG measurement (up to 72 hours of monitoring) and discharge: (1) <5 days between last measurement and discharge, 0.0941 (95% confidence interval [CI] = 0.0706–0.1191); 5 to 10 days between last measurement and discharge, 0.0946 (95% CI = 0.0631–0.1290); >10 days between last measurement and discharge, 0.0998 (95% CI = 0.0698–0.1335). After adjusting for covariates, increase in peak epileptiform activity burden from 0 to 100% increased the probability of poor outcome by 35%.

Interpretation

Automated measurement of peak epileptiform activity burden affords a convenient, consistent, and quantifiable target for future multicenter randomized trials investigating whether suppressing epileptiform activity improves outcomes. ANN NEUROL 2021;90:300–311
Soybean trypsin inhibitor and urease activities and their correlations as affected by heating method, duration, sample matrix, and prior soaking
Authors: Liu Keshun , Ruiz Nelson
Published: July 2021

Urease activity (UA) in soybeans has historically been measured to indicate heating inadequacy. Yet, over the years, controversy has emerged regarding the reliability of UA as a heating index and surrogate for trypsin inhibitor activity (TIA). In Experiments 1–4, raw soybean materials with different matrices (whole beans, flakes, full‐fat and defatted flours) were selectively subjected to steaming, boiling, or dry oven toasting for various durations. For steaming or boiling soybeans, with or without prior soaking was another factor. Reduction rates of TIA and UA with heating time were compared, their correlation coefficients were determined and statistically treated. Experiment 5 entailed collecting 30 commercial soybean meals and measuring TIA and UA without further treatments. By combining the five experiments into a single study, the most comprehensive spectra regarding relative decreasing rates of TIA and UA with heating time and their correlations were obtained. Results show that the reduction rate of UA could be slower than, close to, or faster than that of TIA, depending on combinations of four factors (sample matrix, with or without prior soaking, heating method and interval). UA reached zero within shorter heating durations, while TIA maintained residual values at the longest durations. Consequently, positive correlations between TIA and UA varied from insignificant to very strong. UA was a reliable index for heating inadequacy and surrogate for TIA in soybean products heated by several single combinations of the four factors, but for those heated by other single or mixed combinations, it was unreliable, and TIA should be measured directly.
Fisheries induced shift in sea snake community assemblages along the Konkan coast, India
Authors: Rao Chetan , Dsouza Shawn , Gupta Trisha , Manoharakrishnan Muralidharan , Lobo Aaron Savio
Published: July 2021

The impacts of fisheries on several charismatic marine fauna have been a subject of global concern. Sea snakes share the same habitats as many commercially important fish species and often end up as fisheries bycatch.

Previous studies of bycatch from India have been limited to individual reports of mortality, with little information on the regional community structure of sea snakes. This study was carried out along the Konkan coast, off the central west coast of India, between 2016 and 2018, to determine trends in the bycatch of sea snakes in coastal fisheries.

In this study, 922 sea snakes were encountered in 916.57 gillnet haul hours and 449.16 trawlers haul hours of fishing, comprising largely of two species: beaked sea snake (Hydrophis schistosus) and spine‐bellied sea snake (Hydrophis curtus) (83.05 and 16.94% respectively) which was in stark contrast to a similar study conducted in 2002–03, which recorded a dominance of H. curtus (84%) followed by H. schistosus (14%) in the same region. Both studies, however, indicated higher mortality in H. curtus than in H. schistosus in trawl nets.

This study highlights the significant impact of non‐selective fishing practices on regional assemblages of other marine organisms such as sea snakes from South Asia, which has been relatively understudied, and the potential consequences for local ecosystems.
Histidine Tautomerism Driving Human Islet Amyloid Polypeptide Aggregation in the Early Stages of Diabetes Mellitus Progression: Insight at the Atomistic Level
Authors: Salimi Abbas , Chatterjee Sompriya , Yong Lee Jin
Published: July 2021

Early oligomerization of human islet amyloid polypeptide (hIAPP), which is accountable for β‐cell death, has been implicated in the progression of type 2 diabetes mellitus. Some researches have shown the connection between hIAPP and Alzheimer's disease as well. However, the mechanism of peptide accumulation and associated cytotoxicity remains unclear. Due to the unique properties and significant role of histidine in protein sequences, here for the first time, the tautomeric effect of histidine at the early stages of amylin misfolding was investigated via molecular dynamics simulations. Considering Tau and Pi tautomeric forms of histidine (Tau and Pi tautomers are denoted as ϵ and δ, respectively), simulations were performed on two possible isomers of amylin. Our analysis revealed a higher probability of transient α‐helix generation in the δ isomer in monomeric form. In dimeric forms, the δδ and δϵ conformations showed an elevated amount of α‐helix and lower coil in comparison to the ϵϵ dimer. Due to the significant role of α‐helix in membrane disruption and transition to β‐sheet structure, these results may imply a noticeable contribution of the δ isomer and the δδ and δϵ dimers rather than ϵ and ϵϵ conformations in the early stages of diabetes initiation. Our results may aid in elucidating the hIAPP self‐association process in the etiology of amyloidosis.
H∞ output quantized control for networked control systems under resilient event‐triggered mechanism and aperiodic denial‐of‐service attacks
Authors: Gao Lisai , Li Fuqiang , Fu Jingqi
Published: July 2021

This paper studies H∞ output quantized control for networked control systems (NCSs) under resilient event‐triggered mechanism (ETM) and aperiodic denial‐of‐service (DoS) attacks. First, by integrating attack information into triggering conditions, an output‐based resilient ETM is introduced. Second, a switched system model is established, which integrates impacts of aperiodic jammer, resilient ETM, quantization, and disturbances into a unified framework. Third, less conservative exponential stability criteria are obtained with guaranteed H∞ performance. Further, sufficient conditions for co‐designing dynamic output feedback controller and resilient ETM are presented. Finally, an example confirms effectiveness of the proposed methods.