bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure S2 from miR-25 Modulates Invasiveness and Dissemination of Human Prostate Cancer Cells via Regulation of αv- and α6-Integrin Expression
Authors: Zoni E. , van der Horst G. , van de Merbel A.F. , Chen L. , Rane J.K. , Pelger R.C.M. , Collins A.T. , Visakorpi T. , Snaar-Jagalska B.E. , Maitland N.J. , van der Pluijm G.
Published: March 2023

Supplementary Figure S2. miR-25 strongly changes cell morphology without affecting proliferation.
Table Supplementary S-I from Chemotherapeutic Agents Subvert Tumor Immunity by Generating Agonists of Platelet-Activating Factor
Authors: Sahu Ravi P. , Ocana Jesus A. , Harrison Kathleen A. , Ferracini Matheus , Touloukian Christopher E. , Al-Hassani Mohammed , Sun Louis , Loesch Mathew , Murphy Robert C. , Althouse Sandra K. , Perkins Susan M. , Speicher Paul J. , Tyler Douglas S. , Konger Raymond L. , Travers Jeffrey B.
Published: March 2023

Table Supplementary S-I. Glycerophosphocholine species generated in response to etoposide treatment of B16F10 cells
Supplementary Tables S4-S10 for Dang et al from ΔNp63α Promotes Breast Cancer Cell Motility through the Selective Activation of Components of the Epithelial-to-Mesenchymal Transition Program
Authors: Dang Tuyen T. , Esparza Matthew A. , Maine Erin A. , Westcott Jill M. , Pearson Gray W.
Published: March 2023

Supplementary tables related to miRNA and mRNA expression analysis.
Supplementary Table S1 from Activation Status of the Pregnane X Receptor Influences Vemurafenib Availability in Humanized Mouse Models
Authors: MacLeod A. Kenneth , McLaughlin Lesley A. , Henderson Colin J. , Wolf C. Roland
Published: March 2023

Apparent kinetic parameters of formation of OH-vemurafenib.
Supplementary Figure 4 from Tumor-Induced Pressure in the Bone Microenvironment Causes Osteocytes to Promote the Growth of Prostate Cancer Bone Metastases
Authors: Sottnik Joseph L. , Dai Jinlu , Zhang Honglai , Campbell Brittany , Keller Evan T.
Published: March 2023

Supplementary Figure 4: CCL5 promotes migration and invasion of PCa. A) CCL5 was measured in CM from non-pressurized MLO-Y4 cells after normalization by protein concentration. B) MLO-Y4 CM was incubated with neutralizing antibody (1 µg/ml) against CCL5 and isotype control antibody (1 µg/ml) before being used as a chemoattractant for PCa cell lines. Neutralization of CM derived CCL5 significantly inhibited PCa migration and invasion. C) Based upon measurements of CCL5 produced by OCy at 0 and 40 mmHg, recombinant CCL5 was added to 0 mmHg CM and used in migration and invasion assays. ELISA data was analyzed using Student's two-tailed unpaired t-test. All other data was analyzed by One-way ANOVA with Bonferroni post-test. All bars represent significant relationships of p<0.05.
Supplementary Table S2 from Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b
Authors: Vasilyeva Aksana , Durmus Selvi , Li Lie , Wagenaar Els , Hu Shuiying , Gibson Alice A. , Panetta John C. , Mani Sridhar , Sparreboom Alex , Baker Sharyn D. , Schinkel Alfred H.
Published: March 2023

Sorafenib and SG pharmacokinetic parameters in mice and rats.
Supplementary Figure S5 from Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b
Authors: Vasilyeva Aksana , Durmus Selvi , Li Lie , Wagenaar Els , Hu Shuiying , Gibson Alice A. , Panetta John C. , Mani Sridhar , Sparreboom Alex , Baker Sharyn D. , Schinkel Alfred H.
Published: March 2023

Nonlinear mixed-effects modeling of sorafenib plasma concentrations in wildtype and Abcc2(-/-) mice.
Supplementary Figure S6 from Mdm2 and Aurora Kinase A Inhibitors Synergize to Block Melanoma Growth by Driving Apoptosis and Immune Clearance of Tumor Cells
Authors: Vilgelm Anna E. , Pawlikowski Jeff S. , Liu Yan , Hawkins Oriana E. , Davis Tyler A. , Smith Jessica , Weller Kevin P. , Horton Linda W. , McClain Colt M. , Ayers Gregory D. , Turner David C. , Essaka David C. , Stewart Clinton F. , Sosman Jeffrey A. , Kelley Mark C. , Ecsedy Jeffrey A. , Johnston Jeffrey N. , Richmond Ann
Published: March 2023

Supplementary Figure S6. Results of the flow cytometric analysis of indicated populations of leukocytes in spleen (A) and bone marrow (B) of C57Bl/6 mice bearing B16F0 melanoma tumors.
Supplementary Figure and Table legends from Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function
Authors: Rajeshkumar N.V. , Dutta Prasanta , Yabuuchi Shinichi , de Wilde Roeland F. , Martinez Gary V. , Le Anne , Kamphorst Jurre J. , Rabinowitz Joshua D. , Jain Sanjay K. , Hidalgo Manuel , Dang Chi V. , Gillies Robert J. , Maitra Anirban
Published: March 2023

Supplementary Figures and Table legends
Supplementary Figure 3 from Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity
Authors: Caruso Hillary G. , Hurton Lenka V. , Najjar Amer , Rushworth David , Ang Sonny , Olivares Simon , Mi Tiejuan , Switzer Kirsten , Singh Harjeet , Huls Helen , Lee Dean A. , Heimberger Amy B. , Champlin Richard E. , Cooper Laurence J.N.
Published: March 2023

Activation and functional response of Cetux-CAR+ and Nimo-CAR+ T cells in response to cell lines with varying endogenous EGFR expression
Supplementary Figure 1 from Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity
Authors: Caruso Hillary G. , Hurton Lenka V. , Najjar Amer , Rushworth David , Ang Sonny , Olivares Simon , Mi Tiejuan , Switzer Kirsten , Singh Harjeet , Huls Helen , Lee Dean A. , Heimberger Amy B. , Champlin Richard E. , Cooper Laurence J.N.
Published: March 2023

Schematic of plasmids and AaPC
Supplementary Figures S1-S12 from Dll4 Blockade in Stromal Cells Mediates Antitumor Effects in Preclinical Models of Ovarian Cancer
Authors: Kuhnert Frank , Chen Guoying , Coetzee Sandra , Thambi Nithya , Hickey Carlos , Shan Jing , Kovalenko Pavel , Noguera-Troise Irene , Smith Eric , Fairhurst Jeanette , Andreev Julian , Kirshner Jessica R. , Papadopoulos Nicholas , Thurston Gavin
Published: March 2023

Supplementary Figure S1: Correlation of REGN421 serum concentrations and anti-HT1080 tumor activity Supplementary Figure S2: The potent anti-tumor activity of targeting Dll4 in ovarian xenograft models is dependent on blocking stromal Dll4 Supplementary Figure S3: Dll4 antibody REGN1035 treatment induces abnormal tumor vessels in ovarian cancer xenograft models Supplementary Figure S4: Dll4 expression in ovarian cancer xenograft models is restricted to the tumor vasculature Supplementary Figure S5: Notch receptor expression in ovarian cancer xenograft models Supplementary Figure S6: Notch signaling in TOV-112D cells is mediated predominantly by Notch1 Supplementary Figure S7: Combined blockade of Dll4 and VEGF reverses liver vascular changes induced by Dll4 blockade alone Supplementary Figure S8: Dll4 is expressed in the endothelium of adult heart and liver Supplementary Figure S9: Notch1 signaling activity in heart and liver is dependent on Dll4 Supplementary Figure S10: Pericyte coverage in ovarian xenograft tumors is unaltered in response to anti-Dll4 antibody treatment Supplementary Figure S11: Direct contact between endothelial and tumor cells in TOV-112D tumors Supplementary Figure S12: Direct contact between endothelial and tumor cells in A2780 tumors
Supplementary Figures S1-S4 from YAP Promotes Malignant Progression of Lkb1-Deficient Lung Adenocarcinoma through Downstream Regulation of Survivin
Authors: Zhang Wenjing , Gao Yijun , Li Fuming , Tong Xinyuan , Ren Yan , Han Xiangkun , Yao Shun , Long Fei , Yang Zhongzhou , Fan Hengyu , Zhang Lei , Ji Hongbin
Published: March 2023

The Lungs from SP-C-YAP transgenic mice exhibited higher level of YAP expression in comparison with those of wide type (WT) mice ; Ectopic YAP expression in KrasG12D mice increased lung tumor burden without affecting total tumor number ; The effect of Yap knockout upon tumor number and the percentage of different pathological lesions including AAH/Adenoma, Adenocarcinoma (ADC) and Squamous cell carcinoma ; The functional link between Survivin and Yap in lung tumor growth .
Supplementary figure 1Figure S1 from Decoy Receptor DcR1 Is Induced in a p50/Bcl3–Dependent Manner and Attenuates the Efficacy of Temozolomide
Authors: Mansour Nassir M. , Bernal Giovanna M. , Wu Longtao , Crawley Clayton D. , Cahill Kirk E. , Voce David J. , Balyasnikova Irina V. , Zhang Wei , Spretz Ruben , Nunez Luis , Larsen Gustavo F. , Weichselbaum Ralph R. , Yamini Bakhtiar
Published: March 2023

Supplementary figure 1. A, Venn diagram showing overview of genes significantly (FDR < 0.05) altered in response to TMZ in U87 cells stably expressing control or p105 shRNA. DCR1 (TNFRSF10C) was identified as a gene specific to control cells. B, flow cytometric analysis of DcR1 surface expression in U87 cells following treatment with 100 μM TMZ for the indicated time. C, flow cytometric analysis of DcR1 expression in U87-sh-cntl and U87-sh-p105 cells following treatment with TMZ at the indicated concentration. D, immunoblot with anti-p53 and anti-p21 antibodies in U87 cells at indicated time following treatment with 100 μM TMZ.
Supplemental figure and table legends from Neutrophil Extracellular Traps Accumulate in Peripheral Blood Vessels and Compromise Organ Function in Tumor-Bearing Animals
Authors: Cedervall Jessica , Zhang Yanyu , Huang Hua , Zhang Lei , Femel Julia , Dimberg Anna , Olsson Anna-Karin
Published: March 2023

Supplemental figure and table legends
Supplemental Figure 4 from Neutrophil Extracellular Traps Accumulate in Peripheral Blood Vessels and Compromise Organ Function in Tumor-Bearing Animals
Authors: Cedervall Jessica , Zhang Yanyu , Huang Hua , Zhang Lei , Femel Julia , Dimberg Anna , Olsson Anna-Karin
Published: March 2023

Supplemental Figure 4: Mice with tumors lacking G-CSF expression do not show impaired function of the kidney vasculature.
Supplementary Methods and References from Chronic Inflammation Induces a Novel Epigenetic Program That Is Conserved in Intestinal Adenomas and in Colorectal Cancer
Authors: Abu-Remaileh Monther , Bender Sebastian , Raddatz Günter , Ansari Ihab , Cohen Daphne , Gutekunst Julian , Musch Tanja , Linhart Heinz , Breiling Achim , Pikarsky Eli , Bergman Yehudit , Lyko Frank
Published: March 2023

Supplementary Methods and References. Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplementary Figures S1-S8 from Chronic Inflammation Induces a Novel Epigenetic Program That Is Conserved in Intestinal Adenomas and in Colorectal Cancer
Authors: Abu-Remaileh Monther , Bender Sebastian , Raddatz Günter , Ansari Ihab , Cohen Daphne , Gutekunst Julian , Musch Tanja , Linhart Heinz , Breiling Achim , Pikarsky Eli , Bergman Yehudit , Lyko Frank
Published: March 2023

Supplementary Figures S1-S8. Intestinal inflammation and tumor formation in the AOM/DSS model (S1); Methylome analysis of the mouse AOM/DSS model (S2); Global hypermethylation of intestinal DMVs in the AOM/DSS model (S3); Transcriptome analysis of the mouse AOM/DSS model (S4); Representative 454 bisulfite sequencing results for the Adh1 DMV in wild-type and adenoma-derived epithelium (S5); Inhibition of alcohol dehydrogenase enhances the growth of established organoids (S6); VDR as a representative example for a human gene associated with a DMV-like structure (S7); Definition of a minimum subset of genes for sample classification (S8).
Supplemental Figures S1-S6 from Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy
Authors: Picaud Sarah , Fedorov Oleg , Thanasopoulou Angeliki , Leonards Katharina , Jones Katherine , Meier Julia , Olzscha Heidi , Monteiro Octovia , Martin Sarah , Philpott Martin , Tumber Anthony , Filippakopoulos Panagis , Yapp Clarence , Wells Christopher , Che Ka Hing , Bannister Andrew , Robson Samuel , Kumar Umesh , Parr Nigel , Lee Kevin , Lugo Dave , Jeffrey Philip , Taylor Simon , Vecellio Matteo L. , Bountra Chas , Brennan Paul E. , O'Mahony Alison , Velichko Sharlene , Müller Susanne , Hay Duncan , Daniels Danette L. , Urh Marjeta , La Thangue Nicholas B. , Kouzarides Tony , Prinjha Rab , Schwaller Jürg , Knapp Stefan
Published: March 2023

BLI evaluation of I-CBP112 selectivity (S1); BioMAP data for I-CBP112 (S2); Effects on MLL-AF9 and NUP98-HOXA9 (S3); Immunophenotype of injected MLL-AF9 cells (S4); Cell survival data (S5); Synergy with JQ1 and doxorubicin (S6).
Supplemental Figure 1 from Colon Cancer Growth and Dissemination Relies upon Thrombin, Stromal PAR-1, and Fibrinogen
Authors: Adams Gregory N. , Rosenfeldt Leah , Frederick Malinda , Miller Whitney , Waltz Dusty , Kombrinck Keith , McElhinney Kathryn E. , Flick Matthew J. , Monia Brett P. , Revenko Alexey S. , Palumbo Joseph S.
Published: March 2023

Supplemental Figure 1. Comparison of tumor growth following injection of MC38 cells
supplementary figure 6 from Enhanced MET Translation and Signaling Sustains K-Ras–Driven Proliferation under Anchorage-Independent Growth Conditions
Authors: Fujita-Sato Saori , Galeas Jacqueline , Truitt Morgan , Pitt Cameron , Urisman Anatoly , Bandyopadhyay Sourav , Ruggero Davide , McCormick Frank
Published: March 2023

supplementary figure 6. Anchorage independent culture conditions enhance Met translation.
supplementary figure 4 from Enhanced MET Translation and Signaling Sustains K-Ras–Driven Proliferation under Anchorage-Independent Growth Conditions
Authors: Fujita-Sato Saori , Galeas Jacqueline , Truitt Morgan , Pitt Cameron , Urisman Anatoly , Bandyopadhyay Sourav , Ruggero Davide , McCormick Frank
Published: March 2023

supplementary figure 4. Sensitivity to MEK1/2 inhibitor (GSK1120212) in monolayer and anchorage independent culture conditions.
Supplementary Table S7 from Genetic Deletion of AEG-1 Prevents Hepatocarcinogenesis
Authors: Robertson Chadia L. , Srivastava Jyoti , Siddiq Ayesha , Gredler Rachel , Emdad Luni , Rajasekaran Devaraja , Akiel Maaged , Shen Xue-Ning , Guo Chunqing , Giashuddin Shah , Wang Xiang-Yang , Ghosh Shobha , Subler Mark A. , Windle Jolene J. , Fisher Paul B. , Sarkar Devanand
Published: March 2023

List of antibodies.
Supplementary Table S6 from Genetic Deletion of AEG-1 Prevents Hepatocarcinogenesis
Authors: Robertson Chadia L. , Srivastava Jyoti , Siddiq Ayesha , Gredler Rachel , Emdad Luni , Rajasekaran Devaraja , Akiel Maaged , Shen Xue-Ning , Guo Chunqing , Giashuddin Shah , Wang Xiang-Yang , Ghosh Shobha , Subler Mark A. , Windle Jolene J. , Fisher Paul B. , Sarkar Devanand
Published: March 2023

Ingenuity upstream regulator analysis.
Supplementary Table S4 from Genetic Deletion of AEG-1 Prevents Hepatocarcinogenesis
Authors: Robertson Chadia L. , Srivastava Jyoti , Siddiq Ayesha , Gredler Rachel , Emdad Luni , Rajasekaran Devaraja , Akiel Maaged , Shen Xue-Ning , Guo Chunqing , Giashuddin Shah , Wang Xiang-Yang , Ghosh Shobha , Subler Mark A. , Windle Jolene J. , Fisher Paul B. , Sarkar Devanand
Published: March 2023

Serum liver enzyme levels 48 h after injection of DEN.
Supplementary Figure S2 from CDK4/6 Inhibitor PD 0332991 Sensitizes Acute Myeloid Leukemia to Cytarabine-Mediated Cytotoxicity
Authors: Yang Chenyi , Boyson Cynthia A. , Di Liberto Maurizio , Huang Xiangao , Hannah Jeffrey , Dorn David C. , Moore Malcolm A.S. , Chen-Kiang Selina , Zhou Pengbo
Published: March 2023

Supplementary Figure S2. PD 0332991 synchronization enhanced cytotoxic killing of U937 cells by Ara-C.
Supplementary Table 2 from Interferon Regulatory Factor-1 Signaling Regulates the Switch between Autophagy and Apoptosis to Determine Breast Cancer Cell Fate
Authors: Schwartz-Roberts Jessica L. , Cook Katherine L. , Chen Chun , Shajahan-Haq Ayesha N. , Axelrod Margaret , Wärri Anni , Riggins Rebecca B. , Jin Lu , Haddad Bassem R. , Kallakury Bhaskar V. , Baumann William T. , Clarke Robert
Published: March 2023

Relationship between IRF1 and ATG7 in human tissue microarrays.
Supplementary Figure S4 from CD271 Expression on Patient Melanoma Cells Is Unstable and Unlinked to Tumorigenicity
Authors: Boyle Samantha E. , Fedele Clare G. , Corbin Vincent , Wybacz Elisha , Szeto Pacman , Lewin Jeremy , Young Richard J. , Wong Annie , Fuller Robert , Spillane John , Speakman David , Donahoe Simon , Pohl Miklos , Gyorki David , Henderson Michael A. , Johnstone Ricky W. , Papenfuss Anthony T. , Shackleton Mark
Published: March 2023

Melanoma initiating cell frequency.
Video 2 from Impact of Metabolic Heterogeneity on Tumor Growth, Invasion, and Treatment Outcomes
Authors: Robertson-Tessi Mark , Gillies Robert J. , Gatenby Robert A. , Anderson Alexander R.A.
Published: March 2023

Video 2: Buffer therapy. Simulation of buffer therapy
Supplementary Figure Legends from CD271 Expression on Patient Melanoma Cells Is Unstable and Unlinked to Tumorigenicity
Authors: Boyle Samantha E. , Fedele Clare G. , Corbin Vincent , Wybacz Elisha , Szeto Pacman , Lewin Jeremy , Young Richard J. , Wong Annie , Fuller Robert , Spillane John , Speakman David , Donahoe Simon , Pohl Miklos , Gyorki David , Henderson Michael A. , Johnstone Ricky W. , Papenfuss Anthony T. , Shackleton Mark
Published: March 2023

Legend for Supplementary Figures S1-S8.
Supplemental Figure S3 from Targeted Deletion of p53 in Lgr5-Expressing Intestinal Stem Cells Promotes Colon Tumorigenesis in a Preclinical Model of Colitis-Associated Cancer
Authors: Davidson Laurie A. , Callaway Evelyn S. , Kim Eunjoo , Weeks Brad R. , Fan Yang-Yi , Allred Clinton D. , Chapkin Robert S.
Published: March 2023

Carcinogen treatment effects on colonic stem cell proliferation.
Supplementary Tables S1-S5 from Cytidine Deaminase Axis Modulated by miR-484 Differentially Regulates Cell Proliferation and Chemoresistance in Breast Cancer
Authors: Ye Fu-Gui , Song Chuan-Gui , Cao Zhi-Gang , Xia Chen , Chen Dan-Na , Chen Li , Li Shan , Qiao Feng , Ling Hong , Yao Ling , Hu Xin , Shao Zhi-Ming
Published: March 2023

Supplementary Tables S1-S5: Final concentrations of gemcitabine in the culture medium corresponding to each cycle (S1); Nucletide sequences of PCR primers used for amplification of ALDH1A3, CDA, DST, FMO3, MAOA, PTHLH, XDH, UGT1A1, hENT1, NT5C, DCK, DCTD, CMPK1, NME1 (S2); Selected Genes Related to Drug Metabolism/Resistance according to the GO analysis (S3); Clinicopathological variables and CDA expression in the studied cases (S4); Univariate and multivariate analysis of DFS (S5).
Supplemental Figure S5 from A Novel Bispecific Antibody Targeting EGFR and cMet Is Effective against EGFR Inhibitor–Resistant Lung Tumors
Authors: Moores Sheri L. , Chiu Mark L. , Bushey Barbara S. , Chevalier Kristen , Luistro Leopoldo , Dorn Keri , Brezski Randall J. , Haytko Peter , Kelly Thomas , Wu Sheng-Jiun , Martin Pauline L. , Neijssen Joost , Parren Paul W.H.I. , Schuurman Janine , Attar Ricardo M. , Laquerre Sylvie , Lorenzi Matthew V. , Anderson G. Mark
Published: March 2023

Efficacy of JNJ-61186372 in H292-HGF Xenograft Tumors
Supplemental Figure 2 from CSF1 Receptor Targeting in Prostate Cancer Reverses Macrophage-Mediated Resistance to Androgen Blockade Therapy
Authors: Escamilla Jemima , Schokrpur Shiruyeh , Liu Connie , Priceman Saul J. , Moughon Diana , Jiang Ziyue , Pouliot Frederic , Magyar Clara , Sung James L. , Xu Jingying , Deng Gang , West Brian L. , Bollag Gideon , Fradet Yves , Lacombe Louis , Jung Michael E. , Huang Jiaoti , Wu Lily
Published: March 2023

ABT also induced an immunosuppressive phenotype in TAMs.
Supplementary Table S2 from miR-634 Activates the Mitochondrial Apoptosis Pathway and Enhances Chemotherapy-Induced Cytotoxicity
Authors: Fujiwara Naoto , Inoue Jun , Kawano Tatsuyuki , Tanimoto Kousuke , Kozaki Ken-ichi , Inazawa Johji
Published: March 2023

Supplementary Table S2. List of GO terms enriched among the predicted target genes of miR-634.
Supplementary Table S1 from miR-634 Activates the Mitochondrial Apoptosis Pathway and Enhances Chemotherapy-Induced Cytotoxicity
Authors: Fujiwara Naoto , Inoue Jun , Kawano Tatsuyuki , Tanimoto Kousuke , Kozaki Ken-ichi , Inazawa Johji
Published: March 2023

Supplementary Table S1. List of the 626 predicted target genes of miR-634.
Supplementary Table S3 from The miR-146b-3p/PAX8/NIS Regulatory Circuit Modulates the Differentiation Phenotype and Function of Thyroid Cells during Carcinogenesis
Authors: Riesco-Eizaguirre Garcilaso , Wert-Lamas León , Perales-Patón Javier , Sastre-Perona Ana , Fernández Lara P. , Santisteban Pilar
Published: March 2023

Selected target genes most extensively regulated by miRs in PTC.
Supplemental Figure 2 from FGFR1 Induces Glioblastoma Radioresistance through the PLCγ/Hif1α Pathway
Authors: Gouazé-Andersson Valérie , Delmas Caroline , Taurand Marion , Martinez-Gala Judith , Evrard Solène , Mazoyer Sandrine , Toulas Christine , Cohen-Jonathan-Moyal Elizabeth
Published: March 2023

Survival fractions of (A) U87 siScr and U87 siFGFR1 cells, and (B) LN18 siScr and LN18 siFGFR1, were determined at 2, 4, and 6 Gy by clonogenic assay.
Supplementary Table S1 from The miR-146b-3p/PAX8/NIS Regulatory Circuit Modulates the Differentiation Phenotype and Function of Thyroid Cells during Carcinogenesis
Authors: Riesco-Eizaguirre Garcilaso , Wert-Lamas León , Perales-Patón Javier , Sastre-Perona Ana , Fernández Lara P. , Santisteban Pilar
Published: March 2023

Main characteristics of the 8 patients including gender, histological variant, Tumor Node Metastasis (TNM) stage, concomitant thyroid disease and total thyroidectomy.
Supplementary Methods, Figure Legends, Tables 1 - 2, Figures 1 - 7 from VR23: A Quinoline–Sulfonyl Hybrid Proteasome Inhibitor That Selectively Kills Cancer via Cyclin E–Mediated Centrosome Amplification
Authors: Pundir Sheetal , Vu Hai-Yen , Solomon V. Raja , McClure Rebecca , Lee Hoyun
Published: March 2023

Supplementary Materials and Methods for cloning and sulforhodamine B (SRB) assay, analysis of cell cycle distribution, knockdown of cyclin E with siRNA, EdU labelling, molecular docking modeling, and reagents. Supplementary Table S1. VR23 sensitizes paclitaxel-mediated cell killing, as determined by a clonogenic assay of MCF7 cancer cells. Supplementary Table S2. Examination of VR23-induced toxicity, as determined by the levels of ALT (alanine aminotransferase) and AST (aspartate aminotransferase) in ATH490 athymic mice. Supplementary Figure S1. VR23 induces apoptosis in a cancer cell-specific manner. Figure S2. VR23 induces cell cycle arrest in prometaphase and, eventually, apoptosis through the p38 MAPK pathway. Supplementary Figure S3. Cells exposed to VR23 show a variety of different abnormal phenotypes. Supplementary Figure S4. In MCF10A, cyclin E is heavily ubiquitinated in response to bortezomib (Borz), but not to VR23 or MG132. Supplementary Figure S5. VR23 shows effective antitumor activity in mice engrafted with RPMI 8226. Supplementary Figure S6. VR23 does not show any notable adverse effects to animals. Supplementary Figure S7. VR23 does not cause any notable ill-effects on vital organs as determined by their weights.
Table S9 from A Modeling Approach to Explain Mutually Exclusive and Co-Occurring Genetic Alterations in Bladder Tumorigenesis
Authors: Remy Elisabeth , Rebouissou Sandra , Chaouiya Claudine , Zinovyev Andrei , Radvanyi François , Calzone Laurence
Published: March 2023

Table S9. Copy number and mutation data from 178 patients + survival data for 163 patients
Supplementary Figure 1 from Modification of Helicobacter pylori Peptidoglycan Enhances NOD1 Activation and Promotes Cancer of the Stomach
Authors: Suarez Giovanni , Romero-Gallo Judith , Piazuelo M. Blanca , Wang Ge , Maier Robert J. , Forsberg Lennart S. , Azadi Parastoo , Gomez Martin A. , Correa Pelayo , Peek Richard M.
Published: March 2023

Supplemental Figure 1. (A) Western blot and densitometric analysis for expression of PgdA in H. pylori wild type strains B128 (lane 1) and 7.13 (lane 2), a 7.13 pgdA- isogenic mutant strain (lane 3) and a 7.13 pgdA complemented mutant (pgdA/c; lane 4). H. pylori DnaJ was used as a loading control for bacterial protein (Bottom panel) and the ratio between levels of PgdA and DnaJ was calculated (top panel). Data are represented as mean{plus minus}SEM from 2 independent experiments. (B) Putative structure of the MP1470 ion.
Supplementary Figure 3 from The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc(—)
Authors: Tsuchihashi Kenji , Okazaki Shogo , Ohmura Mitsuyo , Ishikawa Miyuki , Sampetrean Oltea , Onishi Nobuyuki , Wakimoto Hiroaki , Yoshikawa Momoko , Seishima Ryo , Iwasaki Yoshimi , Morikawa Takayuki , Abe Shinya , Takao Ayumi , Shimizu Misato , Masuko Takashi , Nagane Motoo , Furnari Frank B. , Akiyama Tetsu , Suematsu Makoto , Baba Eishi , Akashi Koichi , Saya Hideyuki , Nagano Osamu
Published: March 2023

EGFRvIII promotes glutamate release by glioma cells in a kinase-independent manner.
Supplemental Table S8- from The Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma
Authors: Harms Paul William , Vats Pankaj , Verhaegen Monique Elise , Robinson Dan R. , Wu Yi-Mi , Dhanasekaran Saravana Mohan , Palanisamy Nallasivam , Siddiqui Javed , Cao Xuhong , Su Fengyun , Wang Rui , Xiao Hong , Kunju Lakshmi P. , Mehra Rohit , Tomlins Scott A. , Fullen Douglas Randall , Bichakjian Christopher Keram , Johnson Timothy M. , Dlugosz Andrzej Antoni , Chinnaiyan Arul M.
Published: March 2023

Supplemental Table S8. Insertions/deletions in MCC tumors
Supplemental Table S5 from The Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma
Authors: Harms Paul William , Vats Pankaj , Verhaegen Monique Elise , Robinson Dan R. , Wu Yi-Mi , Dhanasekaran Saravana Mohan , Palanisamy Nallasivam , Siddiqui Javed , Cao Xuhong , Su Fengyun , Wang Rui , Xiao Hong , Kunju Lakshmi P. , Mehra Rohit , Tomlins Scott A. , Fullen Douglas Randall , Bichakjian Christopher Keram , Johnson Timothy M. , Dlugosz Andrzej Antoni , Chinnaiyan Arul M.
Published: March 2023

Supplemental Table S5. Statistical summary for exonic mutations in Merkel cell carcinoma cases
Supplemental Table S2 from The Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma
Authors: Harms Paul William , Vats Pankaj , Verhaegen Monique Elise , Robinson Dan R. , Wu Yi-Mi , Dhanasekaran Saravana Mohan , Palanisamy Nallasivam , Siddiqui Javed , Cao Xuhong , Su Fengyun , Wang Rui , Xiao Hong , Kunju Lakshmi P. , Mehra Rohit , Tomlins Scott A. , Fullen Douglas Randall , Bichakjian Christopher Keram , Johnson Timothy M. , Dlugosz Andrzej Antoni , Chinnaiyan Arul M.
Published: March 2023

Supplemental Table S2. Quality metrics for sequencing libraries
Supplemental Figure S1 from A Urokinase Receptor–Bim Signaling Axis Emerges during EGFR Inhibitor Resistance in Mutant EGFR Glioblastoma
Authors: Wykosky Jill , Hu Jingjing , Gomez German G. , Taylor Tiffany , Villa Genaro R. , Pizzo Donald , VandenBerg Scott R. , Thorne Amy Haseley , Chen Clark C. , Mischel Paul S. , Gonias Steven L. , Cavenee Webster K. , Furnari Frank B.
Published: March 2023

Supplemental Figure S1. Generation of EGFR TKi resistant glioma cells
Supplementary Figure S8 from PIK3CAH1047R Accelerates and Enhances KRASG12D-Driven Lung Tumorigenesis
Authors: Green Shon , Trejo Christy L. , McMahon Martin
Published: March 2023

Inhibitory effects of pathway-targeted agents on the proliferation of lung tumor derived cell lines of defined Kras or Pik3ca genotype.
Supplementary Figure S4 from PIK3CAH1047R Accelerates and Enhances KRASG12D-Driven Lung Tumorigenesis
Authors: Green Shon , Trejo Christy L. , McMahon Martin
Published: March 2023

Pharmacodynamic analysis of the inhibitory effects of BYL719 on pAKT in mice bearing KRASG12D/PIK3CAH1047R-driven lung tumors.
Supplementary Figure S3 from PIK3CAH1047R Accelerates and Enhances KRASG12D-Driven Lung Tumorigenesis
Authors: Green Shon , Trejo Christy L. , McMahon Martin
Published: March 2023

Analysis of the consequences of the timing of KRASG12D versus PIK3CAH1047R oncoprotein expression on lung tumorigenesis.
Supplementary Figure Legends from PIK3CAH1047R Accelerates and Enhances KRASG12D-Driven Lung Tumorigenesis
Authors: Green Shon , Trejo Christy L. , McMahon Martin
Published: March 2023

Legends for Supplementary Figures S1-S9.
Supplementary Table 2 from Aberrant Expression of proPTPRN2 in Cancer Cells Confers Resistance to Apoptosis
Authors: Sorokin Alexey V. , Nair Binoj C. , Wei Yongkun , Aziz Kathryn E. , Evdokimova Valentina , Hung Mien-Chie , Chen Junjie
Published: March 2023

Immunohistochemical expression of proPTPRN2 in invasive breast carcinoma specimens in National Cancer Institute Progression tumor microarrays.
Table S5. DAVID functional classification of ixazomib genes. from Proteasomal Inhibition by Ixazomib Induces CHK1 and MYC-Dependent Cell Death in T-cell and Hodgkin Lymphoma
Authors: Ravi Dashnamoorthy , Beheshti Afshin , Abermil Nasséra , Passero Frank , Sharma Jaya , Coyle Michael , Kritharis Athena , Kandela Irawati , Hlatky Lynn , Sitkovsky Michail V. , Mazar Andrew , Gartenhaus Ronald B. , Evens Andrew M.
Published: March 2023

Functional annotation clusters determined from the common genes in ixazomib 25nM/24 hours vs. Control for Jurkat, L540, and L428 cells (Fig. 1C). This was determined through DAVID Gene Functional Classification Tool. The enrichment scores were determined by DAVID through the geometric mean of the EASE scores (modified Fisher Exact).
Supplemetary Video S4 from Snail1-Expressing Fibroblasts in the Tumor Microenvironment Display Mechanical Properties That Support Metastasis
Authors: Stanisavljevic Jelena , Loubat-Casanovas Jordina , Herrera Mercedes , Luque Tomás , Peña Raúl , Lluch Ana , Albanell Joan , Bonilla Félix , Rovira Ana , Peña Cristina , Navajas Daniel , Rojo Federico , García de Herreros Antonio , Baulida Josep
Published: March 2023

Video S4. MDA-MB231 cells on 3D-ECM generated by TGFÃŽÂ²-treated KO MEFs.
Supplementary Figure S4 from Targeting of Runx2 by miR-135 and miR-203 Impairs Progression of Breast Cancer and Metastatic Bone Disease
Authors: Taipaleenmäki Hanna , Browne Gillian , Akech Jacqueline , Zustin Jozef , van Wijnen Andre J. , Stein Janet L. , Hesse Eric , Stein Gary S. , Lian Jane B.
Published: March 2023

Supplementary Figure S4. Delivery of miR-135 and miR-203 decrease the expression of CCL-7 and CXCL-12.
Supplementary Figure S3 from Targeting of Runx2 by miR-135 and miR-203 Impairs Progression of Breast Cancer and Metastatic Bone Disease
Authors: Taipaleenmäki Hanna , Browne Gillian , Akech Jacqueline , Zustin Jozef , van Wijnen Andre J. , Stein Janet L. , Hesse Eric , Stein Gary S. , Lian Jane B.
Published: March 2023

Supplementary Figure S3. Delivery of miR-135 and miR-203 reduce chemotactic migration of MDA-MB-231 cells.
Supplemental Figure 6 from Tumor Radiosensitization by Monomethyl Auristatin E: Mechanism of Action and Targeted Delivery
Authors: Buckel Lisa , Savariar Elamprakash N. , Crisp Jessica L. , Jones Karra A. , Hicks Angel M. , Scanderbeg Daniel J. , Nguyen Quyen T. , Sicklick Jason K. , Lowy Andrew M. , Tsien Roger Y. , Advani Sunil J.
Published: March 2023

Combination of increased delivery of ACPP-cRGD-MMAE with IR significantly improved tumor regression.
Supplemental Figure 5 from Tumor Radiosensitization by Monomethyl Auristatin E: Mechanism of Action and Targeted Delivery
Authors: Buckel Lisa , Savariar Elamprakash N. , Crisp Jessica L. , Jones Karra A. , Hicks Angel M. , Scanderbeg Daniel J. , Nguyen Quyen T. , Sicklick Jason K. , Lowy Andrew M. , Tsien Roger Y. , Advani Sunil J.
Published: March 2023

Polycation conjugated MMAE is cytotoxic to tumor cells.
Supplementary Table S7 from Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs
Authors: Hunter Francis W. , Young Richard J. , Shalev Zvi , Vellanki Ravi N. , Wang Jingli , Gu Yongchuan , Joshi Naveen , Sreebhavan Sreevalsan , Weinreb Ilan , Goldstein David P. , Moffat Jason , Ketela Troy , Brown Kevin R. , Koritzinsky Marianne , Solomon Benjamin , Rischin Danny , Wilson William R. , Wouters Bradly G.
Published: March 2023

Spearman correlation of expression of flavoproteins with TPZ metabolism in tumor cell lines.
Supplementary Table and Figure Legends from Lysophosphatidic Acid Receptor LPAR6 Supports the Tumorigenicity of Hepatocellular Carcinoma
Authors: Mazzocca Antonio , Dituri Francesco , De Santis Flavia , Filannino Addolorata , Lopane Chiara , Betz Regina C. , Li Ying-Yi , Mukaida Naofumi , Winter Peter , Tortorella Cosimo , Giannelli Gianluigi , Sabbà Carlo
Published: March 2023

Legends for Supplementary Tables S1-S3 and Supplementary Figures S1-S7.
Supplementary Table 3 from Identification of a Functional SNP in the 3′UTR of CXCR2 That Is Associated with Reduced Risk of Lung Cancer
Authors: Ryan Bríd M. , Robles Ana I. , McClary Andrew C. , Haznadar Majda , Bowman Elise D. , Pine Sharon R. , Brown Derek , Khan Mohammed , Shiraishi Kouya , Kohno Takashi , Okayama Hirokazu , Modali Ramakrishna , Yokota Jun , Harris Curtis C.
Published: March 2023

List of non-polymorphic SNPs.
Supplementary Table 2 from Identification of a Functional SNP in the 3′UTR of CXCR2 That Is Associated with Reduced Risk of Lung Cancer
Authors: Ryan Bríd M. , Robles Ana I. , McClary Andrew C. , Haznadar Majda , Bowman Elise D. , Pine Sharon R. , Brown Derek , Khan Mohammed , Shiraishi Kouya , Kohno Takashi , Okayama Hirokazu , Modali Ramakrishna , Yokota Jun , Harris Curtis C.
Published: March 2023

List of SNPs that failed primer design.
Supplementary Figures S1-S7 from Lysophosphatidic Acid Receptor LPAR6 Supports the Tumorigenicity of Hepatocellular Carcinoma
Authors: Mazzocca Antonio , Dituri Francesco , De Santis Flavia , Filannino Addolorata , Lopane Chiara , Betz Regina C. , Li Ying-Yi , Mukaida Naofumi , Winter Peter , Tortorella Cosimo , Giannelli Gianluigi , Sabbà Carlo
Published: March 2023

Expression of LPAR1-5 mRNA levels in peritumoral and HCC cell lines (S1); Cell cycle analysis of LPAR6-knocked-down cells versus controls (S2); Absence of apoptosis in stably LPAR6-knocked-down cells (S3); LPAR6 knockdown impairs HCC migration and actin organization but not cells adhesion (S4); Ectopic expression of LPAR6 in human hepatocarcinoma cell line HLE (S5); LPAR6 knockdown affects the gene expression profile in HCC cells (S6); The PIM3 inhibitor, SGI-1776 decreases tumor growth in vivo and in vitro (S7).
Supplementary Figure S5 from β-Catenin Promotes Regulatory T-cell Responses in Tumors by Inducing Vitamin A Metabolism in Dendritic Cells
Authors: Hong Yuan , Manoharan Indumathi , Suryawanshi Amol , Majumdar Tanmay , Angus-Hill Melinda L. , Koni Pandelakis A. , Manicassamy Balaji , Mellor Andrew L. , Munn David H. , Manicassamy Santhakumar
Published: March 2023

Supplementary Figure S5. Therapeutic effect of blocking the β-catenin pathway against established tumors.
Supplementary Video from Keratin-17 Promotes p27KIP1 Nuclear Export and Degradation and Offers Potential Prognostic Utility
Authors: Escobar-Hoyos Luisa F. , Shah Ruchi , Roa-Peña Lucia , Vanner Elizabeth A. , Najafian Nilofar , Banach Anna , Nielsen Erik , Al-Khalil Ramsey , Akalin Ali , Talmage David , Shroyer Kenneth R.
Published: March 2023

Video showing the proposed model: K17 promotes nuclear export and subsequent degradation of tumor-suppressor p27KIP1, promoting sustained proliferation and tumor growth.
Supplementary Figures S1-S5 from Keratin-17 Promotes p27KIP1 Nuclear Export and Degradation and Offers Potential Prognostic Utility
Authors: Escobar-Hoyos Luisa F. , Shah Ruchi , Roa-Peña Lucia , Vanner Elizabeth A. , Najafian Nilofar , Banach Anna , Nielsen Erik , Al-Khalil Ramsey , Akalin Ali , Talmage David , Shroyer Kenneth R.
Published: March 2023

Endogenous expression of K17 in cervical cancer cell lines and knockdown efficiency by siRNAs and shRNAs against K17 in SiHa and CaSki cells (S1); K17 knockdown induces cell-cycle arrest at G1 (S2); K17 knockdown induces p27KIP1 nuclear accumulation (S3); p27KIP1-ubiquitin ligases expression is not altered by K17 knockdown (S4); K17 interacts with p27KIP1 in the nucleus (S5).
Supplementary Figure Legends from PI3K–mTORC2 but not PI3K–mTORC1 Regulates Transcription of HIF2A/EPAS1 and Vascularization in Neuroblastoma
Authors: Mohlin Sofie , Hamidian Arash , von Stedingk Kristoffer , Bridges Esther , Wigerup Caroline , Bexell Daniel , Påhlman Sven
Published: March 2023

Figure legends corresponding to Supplementary Figures 1-4.
Supplementary Figure 8 from Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2−/−IL2Rγnull Immunodeficient Mice
Authors: Sanmamed Miguel F. , Rodriguez Inmaculada , Schalper Kurt A. , Oñate Carmen , Azpilikueta Arantza , Rodriguez-Ruiz Maria E. , Morales-Kastresana Aizea , Labiano Sara , Pérez-Gracia Jose L. , Martín-Algarra Salvador , Alfaro Carlos , Mazzolini Guillermo , Sarno Francesca , Hidalgo Manuel , Korman Alan J. , Jure-Kunkel Maria , Melero Ignacio
Published: March 2023

hPD-1 expression on TILs and PD-L1/B7-H1 expression in tumor compartment.
Supplementary Methods from Multiplex Genome-Edited T-cell Manufacturing Platform for “Off-the-Shelf” Adoptive T-cell Immunotherapies
Authors: Poirot Laurent , Philip Brian , Schiffer-Mannioui Cécile , Le Clerre Diane , Chion-Sotinel Isabelle , Derniame Sophie , Potrel Pierrick , Bas Cécile , Lemaire Laetitia , Galetto Roman , Lebuhotel Céline , Eyquem Justin , Cheung Gordon Weng-Kit , Duclert Aymeric , Gouble Agnès , Arnould Sylvain , Peggs Karl , Pule Martin , Scharenberg Andrew M. , Smith Julianne
Published: March 2023

Supplementary Methods from Multiplex Genome-Edited T-cell Manufacturing Platform for “Off-the-Shelf” Adoptive T-cell Immunotherapies
Supplementary Figures 1 - 5, Tables 1 - 3 from Multiplex Genome-Edited T-cell Manufacturing Platform for “Off-the-Shelf” Adoptive T-cell Immunotherapies
Authors: Poirot Laurent , Philip Brian , Schiffer-Mannioui Cécile , Le Clerre Diane , Chion-Sotinel Isabelle , Derniame Sophie , Potrel Pierrick , Bas Cécile , Lemaire Laetitia , Galetto Roman , Lebuhotel Céline , Eyquem Justin , Cheung Gordon Weng-Kit , Duclert Aymeric , Gouble Agnès , Arnould Sylvain , Peggs Karl , Pule Martin , Scharenberg Andrew M. , Smith Julianne
Published: March 2023

Supplementary figure S1 : Gene disruption analysis in HEK293 cells. Supplementary figure S2: Optimization of the generation of double KO cells Supplementary table S1: Deep sequencing analysis of TCR-negative cells Supplementary figure S3: Representative deletions found at disrupted TRAC gene Supplementary figure S4: Size distribution of the mutations found in TALEN-treated T cells Supplementary table S2: Size of insertions/deletions in mutated CD52/TRAC alleles Supplementary Table S3: NGS sequencing analysis of off target cleavage Supplementary figure S5: Gating strategy for definition of T-cellsubsets in UCART19
Supplementary Tables S1-S2 from Tumor-Promoting Effects of Myeloid-Derived Suppressor Cells Are Potentiated by Hypoxia-Induced Expression of miR-210
Authors: Noman Muhammad Zaeem , Janji Bassam , Hu Shijun , Wu Joseph C. , Martelli Fabio , Bronte Vincenzo , Chouaib Salem
Published: March 2023

Supplementary Tables S1-S2. A panel of 50 genes (predicted mmu-miR-210 targets) chosen from microRNA target predictions tool RNA22 ; SYBR-GREEN RT-qPCR primers for ChIP assay .
Supplementary Figures S1-S2 from Tumor-Promoting Effects of Myeloid-Derived Suppressor Cells Are Potentiated by Hypoxia-Induced Expression of miR-210
Authors: Noman Muhammad Zaeem , Janji Bassam , Hu Shijun , Wu Joseph C. , Martelli Fabio , Bronte Vincenzo , Chouaib Salem
Published: March 2023

Supplementary Figures S1-S2. Tumor-infiltrating MDSCs differentially express CA-IX and GLUT-1 (hypoxia markers) as compared to splenic MDSCs and hypoxia has no effect on miR-21, miR-155, miR-494, and miR-223 expression in splenic MDSCs ; miR-210 in MDSC did not alter their immune suppressive cytokine (IL-6 and IL-10) production and had no effect on PD-L1 .
Supplementary Figure 3 from Immunotargeting of Antigen xCT Attenuates Stem-like Cell Behavior and Metastatic Progression in Breast Cancer
Authors: Lanzardo Stefania , Conti Laura , Rooke Ronald , Ruiu Roberto , Accart Nathalie , Bolli Elisabetta , Arigoni Maddalena , Macagno Marco , Barrera Giuseppina , Pizzimenti Stefania , Aurisicchio Luigi , Calogero Raffaele Adolfo , Cavallo Federica
Published: March 2023

Immunofluorescence analysis of xCT expression in human tissues
Supplementary Figures S1-S12 from Genetic and Pharmacological Screens Converge in Identifying FLIP, BCL2, and IAP Proteins as Key Regulators of Sensitivity to the TRAIL-Inducing Anticancer Agent ONC201/TIC10
Authors: Allen Joshua E. , Prabhu Varun V. , Talekar Mala , van den Heuvel A. Pieter J. , Lim Bora , Dicker David T. , Fritz Jennifer L. , Beck Adam , El-Deiry Wafik S.
Published: March 2023

Supplementary Figures S1-S12. Validation of kinase regulators of ONC201 sensitivity (S1); KSR1 shifts the ONC201, but not lapatinib, dose-response curve downward (S2); KSR1 does not regulate ONC201-induced TRAIL or DR5 (S3); KSR1 does not affect ONC201-mediated inhibition of MAPK or Akt inhibition (S4); Distribution of ONC201 synergy instances by drug (S5); Validation of ONC201 combinatorial activity with approved anti-cancer small molecules (S6); ONC201 synergizes with sorafenib in HepG2 cells (S7); ONC201 and sorafenib cooperatively induce apoptosis, TRAIL, and DR5 in vivo (S8); ONC201 and sorafenib cooperatively induce apoptosis in HepG2 cells (S9); ONC201 and sorafenib combination therapy is well tolerated and effective in vivo (S10); FLIP, Mcl-1, and KSR-1 knockdown enhances ONC201 response in HCT116 cells (S11); Model of ONC201-induced TRAIL signaling and sensitivity factors (S12).
Supplementary Figure 1 from Immunotargeting of Antigen xCT Attenuates Stem-like Cell Behavior and Metastatic Progression in Breast Cancer
Authors: Lanzardo Stefania , Conti Laura , Rooke Ronald , Ruiu Roberto , Accart Nathalie , Bolli Elisabetta , Arigoni Maddalena , Macagno Marco , Barrera Giuseppina , Pizzimenti Stefania , Aurisicchio Luigi , Calogero Raffaele Adolfo , Cavallo Federica
Published: March 2023

Cellular localization and correlation with breast cancer patient clinical outcome (CO) of genes differentially expressed in TUBO cells and tumorspheres
Supplemental Figure S4 from Obesity Contributes to Ovarian Cancer Metastatic Success through Increased Lipogenesis, Enhanced Vascularity, and Decreased Infiltration of M1 Macrophages
Authors: Liu Yueying , Metzinger Matthew N. , Lewellen Kyle A. , Cripps Stephanie N. , Carey Kyle D. , Harper Elizabeth I. , Shi Zonggao , Tarwater Laura , Grisoli Annie , Lee Eric , Slusarz Ania , Yang Jing , Loughran Elizabeth A. , Conley Kaitlyn , Johnson Jeff J. , Klymenko Yuliya , Bruney Lana , Liang Zhong , Dovichi Norman J. , Cheatham Bentley , Leevy W. Matthew , Stack M. Sharon
Published: March 2023

Immunohistochemical analysis of proliferation in murine tumor tissues.
Supplemental Figure S1 from Obesity Contributes to Ovarian Cancer Metastatic Success through Increased Lipogenesis, Enhanced Vascularity, and Decreased Infiltration of M1 Macrophages
Authors: Liu Yueying , Metzinger Matthew N. , Lewellen Kyle A. , Cripps Stephanie N. , Carey Kyle D. , Harper Elizabeth I. , Shi Zonggao , Tarwater Laura , Grisoli Annie , Lee Eric , Slusarz Ania , Yang Jing , Loughran Elizabeth A. , Conley Kaitlyn , Johnson Jeff J. , Klymenko Yuliya , Bruney Lana , Liang Zhong , Dovichi Norman J. , Cheatham Bentley , Leevy W. Matthew , Stack M. Sharon
Published: March 2023

Overview of experimental cohorts.
Supplementary Figure Legends from IL10 and PD-1 Cooperate to Limit the Activity of Tumor-Specific CD8+ T Cells
Authors: Sun Zhaojun , Fourcade Julien , Pagliano Ornella , Chauvin Joe-Marc , Sander Cindy , Kirkwood John M. , Zarour Hassane M.
Published: March 2023

Legend for Supplementary Figures S1-S5.
Table S1 from Multikinase Inhibitors Induce Cutaneous Toxicity through OAT6-Mediated Uptake and MAP3K7-Driven Cell Death
Authors: Zimmerman Eric I. , Gibson Alice A. , Hu Shuiying , Vasilyeva Aksana , Orwick Shelley J. , Du Guoqing , Mascara Gerard P. , Ong Su Sien , Chen Taosheng , Vogel Peter , Inaba Hiroto , Maitland Michael L. , Sparreboom Alex , Baker Sharyn D.
Published: March 2023

Incidence of hand-foot skin reactions in patients treated with kinase inhibitors.
Supplementary Figure S7 from Genetic and Pharmacologic Inhibition of eIF4E Reduces Breast Cancer Cell Migration, Invasion, and Metastasis
Authors: Pettersson Filippa , del Rincon Sonia V. , Emond Audrey , Huor Bonnie , Ngan Elaine , Ng Jonathan , Dobocan Monica C. , Siegel Peter M. , Miller Wilson H.
Published: March 2023

Supplementary Figure S7. Ribavirin reduces eIF4E phosphorylation in 66cl4 tumors.
Supplementary Figure S3 from Genetic and Pharmacologic Inhibition of eIF4E Reduces Breast Cancer Cell Migration, Invasion, and Metastasis
Authors: Pettersson Filippa , del Rincon Sonia V. , Emond Audrey , Huor Bonnie , Ngan Elaine , Ng Jonathan , Dobocan Monica C. , Siegel Peter M. , Miller Wilson H.
Published: March 2023

Supplementary Figure S3. Knockdown or inhibition of eIF4E suppresses MMP-9 production.
Supplemental Table 5 from Host Age Is a Systemic Regulator of Gene Expression Impacting Cancer Progression
Authors: Beheshti Afshin , Benzekry Sébastien , McDonald J. Tyson , Ma Lili , Peluso Michael , Hahnfeldt Philip , Hlatky Lynn
Published: March 2023

Supplemental Table 5. Gene set enrichment analysis (GSEA) for tumors in old mice
Supplementary Figure S3 from Small-Molecule ONC201/TIC10 Targets Chemotherapy-Resistant Colorectal Cancer Stem–like Cells in an Akt/Foxo3a/TRAIL–Dependent Manner
Authors: Prabhu Varun V. , Allen Joshua E. , Dicker David T. , El-Deiry Wafik S.
Published: March 2023

TRAIL-dependent anti-CSC effects of ONC201/TIC10.
Supplementary Figures S1-S8 from CD73 Is Associated with Poor Prognosis in High-Grade Serous Ovarian Cancer
Authors: Turcotte Martin , Spring Kathleen , Pommey Sandra , Chouinard Guillaume , Cousineau Isabelle , George Joshy , Chen Gregory M. , Gendoo Deena M.A. , Haibe-Kains Benjamin , Karn Thomas , Rahimi Kurosh , Le Page Cécile , Provencher Diane , Mes-Masson Anne-Marie , Stagg John
Published: March 2023

Supplementary Figures S1-S8. Suppl. Fig. S1. Meta-analysis of CD73 and CD39 in ovarian cancer gene expression datasets. Suppl. Fig. S2. CD73 and CD8 staining in high grade serous ovarian cancer. Suppl. Fig. S3. Flow cytometry analysis of CD73 expression on 12 human ovarian cancer cell lines. Suppl. Fig. S4. Prognostic value of CD73 protein expression and intraepithelial CD8+ cell density. Suppl. Fig. S5. CD73 gene silencing in OV4485 and SKOV3 human ovarian cancer cells. Suppl. Fig. S6. CD39 and adenosine receptor expression in human ovarian cancer cells. Suppl. Fig. S7. CD73-expressing cancer-associated fibroblasts promote tumor growth in mice. Suppl. Fig. S8. Flow cytometry gating strategy and representative staining of ID8-OVA tumor cell suspension.
Supplementary Materials and Methods, Figure Legends from Genetic and Pharmacological Inactivation of the Purinergic P2RX7 Receptor Dampens Inflammation but Increases Tumor Incidence in a Mouse Model of Colitis-Associated Cancer
Authors: Hofman Paul , Cherfils-Vicini Julien , Bazin Marie , Ilie Marius , Juhel Thierry , Hébuterne Xavier , Gilson Eric , Schmid-Alliana Annie , Boyer Olivier , Adriouch Sahil , Vouret-Craviari Valérie
Published: March 2023

Supplementary Materials and Methods, Figure Legends
Supplementary Figures S1-S7 from Genetic and Pharmacological Inactivation of the Purinergic P2RX7 Receptor Dampens Inflammation but Increases Tumor Incidence in a Mouse Model of Colitis-Associated Cancer
Authors: Hofman Paul , Cherfils-Vicini Julien , Bazin Marie , Ilie Marius , Juhel Thierry , Hébuterne Xavier , Gilson Eric , Schmid-Alliana Annie , Boyer Olivier , Adriouch Sahil , Vouret-Craviari Valérie
Published: March 2023

Supplementary Figures S1-S7. Figure S1: Characterization of heterozygous P2rx7 +/- mice Figure S2: The A740003 pharmacological inhibitor of P2RX7 dampens colitis Figure S3: P2rx7-dependent colonic epithelial cell proliferation Figure S4: Scoring of pre-cancerous dysplasic lesions Figure S5: Body weight curves of WT, P2rx7-/- and A438079-treated mice on a CAC regimen Figure S6: Histological examination of cancerous colonic lesions of WT and P2rx7-/- mice Figure S7: The cancerous microenvironment of P2rx7-/- mice is enriched in neutrophils