bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Vitamin D Adequacy on Thyroid Hormones and Inflammatory Markers after Bariatric Surgery
Authors: França Roberta , Cordeiro Adryana , Pereira Silvia Elaine , Saboya Carlos José , Ramalho Andrea
Published: April 2023

Vitamin D status affects the clinical and corporal outcomes of postoperative patients who undergo a Roux-en-Y gastric bypass (RYGB). The aim of this study was to evaluate the effect of adequate vitamin D serum concentrations on thyroid hormones, body weight, blood cell count, and inflammation after an RYGB. A prospective observational study was conducted with eighty-eight patients from whom we collected blood samples before and 6 months after surgery to evaluate their levels of 25-hydroxyvitamin D 25(OH)D, thyroid hormones, and their blood cell count. Their body weight, body mass index (BMI), total weight loss, and excess weight loss were also evaluated 6 and 12 months after surgery. After 6 months, 58% of the patients achieved an adequate vitamin D nutritional status. Patients in the adequate group showed a decrease in the concentration of thyroid-stimulating hormone (TSH) (3.01 vs. 2.22 µUI/mL, p = 0.017) with lower concentrations than the inadequate group at 6 months (2.22 vs. 2.84 µUI/mL, p = 0.020). Six months after surgery, the group with vitamin D adequacy showed a significantly lower BMI compared with the inadequate group at 12 months (31.51 vs. 35.04 kg/m2, p = 0.018). An adequate vitamin D nutritional status seems to favor a significant improvement in one’s thyroid hormone levels, immune inflammatory profile, and weight loss performance after an RYGB.
Metabolomic Profiling of Bipolar Disorder by 1H-NMR in Serbian Patients
Authors: Simić Katarina , Miladinović Zoran , Todorović Nina , Trifunović Snežana , Avramović Nataša , Gavrilović Aleksandra , Jovanović Silvana , Gođevac Dejan , Vujisić Ljubodrag , Tešević Vele , Tasic Ljubica , Mandić Boris
Published: April 2023

Bipolar disorder (BD) is a brain disorder that causes changes in a person’s mood, energy, and ability to function. It has a prevalence of 60 million people worldwide, and it is among the top 20 diseases with the highest global burden. The complexity of this disease, including diverse genetic, environmental, and biochemical factors, and diagnoses based on the subjective recognition of symptoms without any clinical test of biomarker identification create significant difficulties in understanding and diagnosing BD. A 1H-NMR-based metabolomic study applying chemometrics of serum samples of Serbian patients with BD (33) and healthy controls (39) was explored, providing the identification of 22 metabolites for this disease. A biomarker set including threonine, aspartate, gamma-aminobutyric acid, 2-hydroxybutyric acid, serine, and mannose was established for the first time in BD serum samples by an NMR-based metabolomics study. Six identified metabolites (3-hydroxybutyric acid, arginine, lysine, tyrosine, phenylalanine, and glycerol) are in agreement with the previously determined NMR-based sets of serum biomarkers in Brazilian and/or Chinese patient samples. The same established metabolites (lactate, alanine, valine, leucine, isoleucine, glutamine, glutamate, glucose, and choline) in three different ethnic and geographic origins (Serbia, Brazil, and China) might have a crucial role in the realization of a universal set of NMR biomarkers for BD.
Comparative Metabolomics Profiling Reveals Key Metabolites and Associated Pathways Regulating Tuber Dormancy in White Yam (Dioscorea rotundata Poir.)
Authors: Nwogha Jeremiah S. , Wosene Abtew G. , Raveendran Muthurajan , Obidiegwu Jude E. , Oselebe Happiness O. , Kambale Rohit , Chilaka Cynthia A. , Rajagopalan Veera Ranjani
Published: April 2023

Yams are economic and medicinal crops with a long growth cycle, spanning between 9–11 months due to their prolonged tuber dormancy. Tuber dormancy has constituted a major constraint in yam production and genetic improvement. In this study, we performed non-targeted comparative metabolomic profiling of tubers of two white yam genotypes, (Obiaoturugo and TDr1100873), to identify metabolites and associated pathways that regulate yam tuber dormancy using gas chromatography–mass spectrometry (GC–MS). Yam tubers were sampled between 42 days after physiological maturity (DAPM) till tuber sprouting. The sampling points include 42-DAPM, 56-DAPM, 87DAPM, 101-DAPM, 115-DAPM, and 143-DAPM. A total of 949 metabolites were annotated, 559 in TDr1100873 and 390 in Obiaoturugo. A total of 39 differentially accumulated metabolites (DAMs) were identified across the studied tuber dormancy stages in the two genotypes. A total of 27 DAMs were conserved between the two genotypes, whereas 5 DAMs were unique in the tubers of TDr1100873 and 7 DAMs were in the tubers of Obiaoturugo. The differentially accumulated metabolites (DAMs) spread across 14 major functional chemical groups. Amines and biogenic polyamines, amino acids and derivatives, alcohols, flavonoids, alkaloids, phenols, esters, coumarins, and phytohormone positively regulated yam tuber dormancy induction and maintenance, whereas fatty acids, lipids, nucleotides, carboxylic acids, sugars, terpenoids, benzoquinones, and benzene derivatives positively regulated dormancy breaking and sprouting in tubers of both yam genotypes. Metabolite set enrichment analysis (MSEA) revealed that 12 metabolisms were significantly enriched during yam tuber dormancy stages. Metabolic pathway topology analysis further revealed that six metabolic pathways (linoleic acid metabolic pathway, phenylalanine metabolic pathway, galactose metabolic pathway, starch and sucrose metabolic pathway, alanine-aspartate-glutamine metabolic pathways, and purine metabolic pathway) exerted significant impact on yam tuber dormancy regulation. This result provides vital insights into molecular mechanisms regulating yam tuber dormancy.
Application of Benchtop NMR for Metabolomics Study Using Feces of Mice with DSS-Induced Colitis
Authors: Song Zihao , Ohnishi Yuki , Osada Seiji , Gan Li , Jiang Jiaxi , Hu Zhiyan , Kumeta Hiroyuki , Kumaki Yasuhiro , Yokoi Yuki , Nakamura Kiminori , Ayabe Tokiyoshi , Yamauchi Kazuo , Aizawa Tomoyasu
Published: April 2023

Nuclear magnetic resonance (NMR)-based metabolomics, which comprehensively measures metabolites in biological systems and investigates their response to various perturbations, is widely used in research to identify biomarkers and investigate the pathogenesis of underlying diseases. However, further applications of high-field superconducting NMR for medical purposes and field research are restricted by its high cost and low accessibility. In this study, we applied a low-field, benchtop NMR spectrometer (60 MHz) employing a permanent magnet to characterize the alterations in the metabolic profile of fecal extracts obtained from dextran sodium sulfate (DSS)-induced ulcerative colitis model mice and compared them with the data acquired from high-field NMR (800 MHz). Nineteen metabolites were assigned to the 60 MHz 1H NMR spectra. Non-targeted multivariate analysis successfully discriminated the DSS-induced group from the healthy control group and showed high comparability with high-field NMR. In addition, the concentration of acetate, identified as a metabolite with characteristic behavior, could be accurately quantified using a generalized Lorentzian curve fitting method based on the 60 MHz NMR spectra.
Strata Movement of Gangue Grouting Filling in Subsequent Space for Coal Mining and Analysis of Its Practical Effects
Authors: An Tailong , Wu Zhongya , Zhang Jixiong , Liu Yexian , Duan Gang , Zhou Nan , Yan Hao
Published: April 2023

There is a huge amount of solid waste generated in coal resource exploitation and utilization, leading to effects on the environment and hindering sustainable development. Aiming at the difficulty of disposal of coal-based solid waste from high-yield, high-efficiency mines, this research proposed a technique of gangue grouting filling in subsequent space (GGFSS) for coal mining and explored the movement of key strata backfilled using GGFSS technique and surface deformation characteristics using theoretical analysis and a field measurement method. The results indicate that the equivalent backfilled ratio (EBR) when using GGFSS is defined as the ratio of the grouting volume to available void volume, which is mainly affected by bed separation void volume, grouting volume, and the void volume of the caving zone. Using an EBR ground control mechanical model, the changes in the displacement and bending moment of key strata with the variation of the EBR were investigated. The critical EBR for the rupture of key strata was determined to be 74.44%. On this basis, the calculation methods of equivalent mining height (EMH) and the subsidence factor of GGFSS were proposed and then a surface deformation prediction model of GGFSS was established based on the principle of the probability integration method. The predictions implied that, at an EBR greater than 75%, the surface deformation could be significantly reduced. Engineering applications verified the effect of GGFSS on the control of ground movement. In-situ measurements of concentration, density, and particle size of the filling body were all close to the those designed values: the GGFSS technique shows longer grouting duration and a larger amount of grouting and its filling body can support impervious key strata above the working face in a mine, significantly decreasing surface subsidence.
Optically Active Telecom Defects in MoTe2 Fewlayers at Room Temperature
Authors: Lei Yuxin , Lin Qiaoling , Xiao Sanshui , Li Juntao , Fang Hanlin
Published: April 2023

The optical and electrical properties of semiconductors are strongly affected by defect states. The defects in molybdenum ditelluride (MoTe2) show the potential for quantum light emission at optical fiber communication bands. However, the observation of defect-related light emission is still limited to cryogenic temperatures. In this work, we demonstrate the deep defect states in MoTe2 fewlayers produced via a standard van der Waal material transfer method with a heating process, which enables light emission in the telecommunication O-band. The optical measurements show evidence of localized excitons and strong interaction among defects. Furthermore, the optical emission of defects depends on the thickness of the host materials. Our findings offer a new route for tailoring the optical properties of two-dimensional materials in optoelectronic applications.
Extremely High-Quality Periodic Structures on ITO Film Efficiently Fabricated by Femtosecond Pulse Train Output from a Frequency-Doubled Fabry–Perot Cavity
Authors: Jiang Qilin , Zhang Yuchan , Xu Yufeng , Zhang Shian , Feng Donghai , Jia Tianqing , Sun Zhenrong , Qiu Jianrong
Published: April 2023

This study developed a novel frequency-doubled Fabry–Perot cavity method based on a femtosecond laser of 1030 nm, 190 fs, 1 mJ, and 1 kHz. The time interval (60–1000 ps) and attenuation ratio (0.5–0.9) between adjacent sub-pulses of the 515 nm pulse train were able to be easily adjusted, while the efficiency was up to 50% and remained unchanged. Extremely high-quality low-spatial-frequency LIPSS (LSFL) was efficiently fabricated on an indium tin oxide (ITO) film using a pulse train with a time interval of 150 ps and attenuation ratio of 0.9 focused with a cylindrical lens. Compared with the LSFL induced by the primary Gaussian pulse, the uniformity of the LSFL period was enhanced from 481 ± 41 nm to 435 ± 8 nm, the divergence of structural orientation angle was reduced from 15.6° to 3.7°, and the depth was enhanced from 74.21 ± 14.35 nm to 150.6 ± 8.63 nm. The average line edge roughness and line height roughness were only 7.34 nm and 2.06 nm, respectively. The depths and roughness values were close to or exceeded those of resist lines made by the interference lithography. Compared with the common Fabry–Perot cavity, the laser energy efficiency of the pulse trains and manufacturing efficiency were enhanced by factors of 19 and 25. A very colorful “lotus” pattern with a size of 30×28 mm2 was demonstrated, which was covered with high-quality LSFLs fabricated by a pulse train with optimized laser parameters. Pulse trains can efficiently enhance and prolong the excitation of surface plasmon polaritons, inhibit deposition particles, depress ablation residual heat and thermal shock waves, and eliminate high-spatial-frequency LIPSS formed on LSFL, therefore, producing extremely high-quality LSFL on ITO films.
Biochars from Olive Stones as Carbonaceous Support in Pt/TiO2-Carbon Photocatalysts and Application in Hydrogen Production from Aqueous Glycerol Photoreforming
Authors: Escamilla-Mejía Juan Carlos , Hidalgo-Carrillo Jesús , Martín-Gómez Juan , López-Tenllado Francisco J. , Estévez Rafael , Marinas Alberto , Urbano Francisco J.
Published: April 2023

Several biochars were synthesized from olive stones and used as supports for TiO2, as an active semiconductor, and Pt as a co-catalyst (Pt/TiO2-PyCF and Pt/TiO2-AC). A third carbon-supported photocatalyst was prepared from commercial mesoporous carbon (Pt/TiO2-MCF). Moreover, a Pt/TiO2 solid based on Evonik P25 was used as a reference. The biochars used as supports transferred, to a large extent, their physical and chemical properties to the final photocatalysts. The synthesized catalysts were tested for hydrogen production from aqueous glycerol photoreforming. The results indicated that a mesoporous nature and small particle size of the photocatalyst lead to better H2 production. The analysis of the operational reaction conditions revealed that the H2 evolution rate was not proportional to the mass of the photocatalyst used, since, at high photocatalyst loading, the hydrogen production decreased because of the light scattering and reflection phenomena that caused a reduction in the light penetration depth. When expressed per gram of TiO2, the activity of Pt/TiO2-PyCF is almost 4-times higher than that of Pt/TiO2 (1079 and 273 mmol H2/gTiO2, respectively), which points to the positive effect of an adequate dispersion of a TiO2 phase on a carbonaceous support, forming a highly dispersed and homogeneously distributed titanium dioxide phase. Throughout a 12 h reaction period, the H2 production rate progressively decreases, while the CO2 production rate increases continuously. This behavior is compatible with an initial period when glycerol dehydrogenation to glyceraldehyde and/or dihydroxyacetone and hydrogen predominates, followed by a period in which comparatively slower C-C cleavage reactions begin to occur, thus generating both H2 and CO2.
Preservation of Phenols, Antioxidant Activity, and Cyclic Adenosine Monophosphate in Jujube (Ziziphus jujuba Mill.) Fruits with Different Drying Methods
Authors: Sapkota Govinda , Delgado Efren , VanLeeuwen Dawn , Holguin F. Omar , Flores Nancy , Yao Shengrui
Published: April 2023

Jujube, commonly known as the Chinese date, is a nutritious fruit with medicinal importance. Fresh jujube fruits have a shelf life of about ten days in ambient conditions that can be extended by drying. However, nutrition preservation varies with the drying method and parameters selected. We studied total phenolic content (TPC), proanthocyanidins (PA), vitamin C, cyclic adenosine monophosphate (cAMP), and antioxidant activities in jujube fruits dried with freeze-drying (FD), convective oven drying (OD) at 50 °C, 60 °C, and 75 °C, and sun drying (SD) with FD as a control. The cultivars used for this study were ‘Capri’ and ‘Xiang’ from Las Cruces in 2019, and ‘Sugarcane’, ‘Lang’, and ‘Sherwood’ from Las Cruces and Los Lunas, New Mexico, in 2020. Freeze-drying had the highest of all nutrient components tested, the best estimates of mature jujube fruits’ nutrient contents. Compared with FD, the majority of PA (96–99%) and vitamin C (90–93%) was lost during SD or OD processes. The retention rates of antioxidant activities: DPPH and FRAP were higher in OD at 50/60 °C than SD. SD retained a higher cAMP level than OD at 50/60 °C in both years. The increase in oven drying temperature from 60 °C to 75 °C significantly decreased TPC, PA, antioxidant activities, and cAMP.
Effects of Passovia ovata Mistletoe on Pro-Inflammatory Markers In Vitro and In Vivo
Authors: Magalhães Isadora de Fátima Braga , Figueirêdo Ana Letícia Marinho , da Silva Elizeu Mendes , de Miranda Adryan Adam Batalha , da Rocha Cláudia Quintino , da Silva Calabrese Katia , Almeida-Souza Fernando , Abreu-Silva Ana Lúcia
Published: April 2023

New agents that can suppress inflammatory responses are being sought, since chronic inflammation is associated with several pathologies. This work aims to elucidate phytochemicals from the hydroethanolic extract of mistletoe Passovia ovata (POH) and its anti-inflammatory potential. POH is submitted to HPLC-UV, qualitative analysis of chemical constituents, and flavonoid quantification. Cytotoxicity is evaluated in RAW 264.7 macrophages by MTT. LPS-stimulated RAW 264.7 cells are treated with POH and, after 48 h, the nitrite and cytokine levels are quantified. BALB/c mice are treated by gavage with POH and stimulated with λ-carrageenan to induce paw oedema or peritonitis. POH yield is 25% with anthraquinones, tannins, anthocyanins, anthocyanidins, flavonols, catechins and flavanones present and flavonoid content of 4.44 ± 0.157 mg QE/g dry weight. POH exhibits low cytotoxicity and significantly reduced (p < 0.01) nitrite, IL-1β, IL-6, and TNF-α quantification at 500 μg/mL. POH at 500 mg/kg prevents paw edema increase and also reduces inflammatory infiltrate and mast cells in the footpad. In the peritonitis model, POH does not influence cytokines levels or cell counts. Overall, POH demonstrates a high concentration of flavonoids and prominent effects in the reduction in pro-inflammatory markers in vitro and in the inhibition of paw oedema.
Invest in Your Mental Health, Support Your Career. Exploring the Impact of Mental Health Activities on Movement Capital and the Mediating Role of Flourishing and Career Engagement during the Transition to Work
Authors: Mariani Marco Giovanni , Chiesa Rita , Lo Piccolo Elena , Petruzziello Gerardo
Published: April 2023

The current theorising of career self-management advocates that personal resources that support an adaptive transition to work are bound to individual agency. Yet, research still needs to enrich the empirical exploration of how behaviours in personal life affect careers. For this reason, we explored the impact of mental-health activities—a group of self-help activities that people can perform to increase their mental health—on movement capital among Italian new entrants in the labour market. We also explored a mechanism underlying this relationship by testing the mediating role of flourishing and career engagement. We collected data from 229 Italian university students and recent graduates through an online questionnaire. Contrary to our expectations, we found no significant direct relationship between mental-health activities and movement capital, yet the results supported an indirect relationship. The findings contribute to existing evidence about how personal life behaviours affect career self-management and advance the understanding of the role of mental health activities. This work suggests ways to encourage engagement in self-help behaviours and implement public and higher education interventions to foster these behaviours’ benefits for an adaptive transition to work.
“If We Don’t Listen to Them, We Make Them Lose More than Money:” Exploring Reasons for Underreporting and the Needs of Older Scam Victims
Authors: Parti Katalin , Tahir Faika
Published: April 2023

Highly manipulative online and telephone scams committed by strangers target everyone, but older individuals are especially susceptible to being victimized. This study aimed to (1) identify why older individuals decide not to report scams and, in parallel, (2) explore the needs of victims. Thirty-five interviews were conducted with Virginia residents who were 60 years or older in 2021. The interpretive phenomenological analysis of the semi-structured interviews revealed that victims are reluctant to report crimes or ask for help from their family or community because much-needed emotional, educational, and technical help is often inaccessible or inadequate. In particular, we found that family responses tend to intrude on privacy, community responses are not meaningful or are non-existent, police responses are inadequate, and prevention programs are inaccessible and not specified to meet the needs of older age groups. We recommend developing age-appropriate prevention and education programs, by applying the intergenerational group approach, and actively listening to victims’ concerns before deciding what means of help should be applied. Research implications and recommendations are presented.
Numerical Investigation of Aerodynamic Performances for NREL 5-MW Offshore Wind Turbine
Authors: Zhang Qiqing , Wang Xiuling
Published: April 2023

As one of the preferred types of renewable energy, wind energy is rapidly growing. The purpose of this study is to provide a comprehensive and in-depth numerical analysis on the National Renewable Energy Lab (NREL) 5-MW offshore wind turbine to help understand the wind turbine’s aerodynamic features. In this research, the preprocessing was conducted by using SolidWorks modeling, and a realizable k-ε viscous model from ANSYS/FLUENT was used as the solver in the CFD simulation. Eight test cases were developed, and fixed inlet velocity 9 m/s was set as the baseline case. After the initial mesh independent study and model validation, a detailed numerical analysis was carried out. The results of near wake flow features, torque and thrust, pressure and pressure coefficient distribution, limiting streamline along wind turbine blades, power coefficient as a function of tip speed ratio were evaluated. Whenever possible, simulation results were compared with data in the literature (numerical or experimental), and good agreement was observed. The detailed wind turbine aerodynamic analysis results are expected to provide valuable input to wind turbine design and thus to improve the effectiveness of harnessing wind energy. Research is on the way to further understanding the influence of different inflow conditions on the aerodynamic characteristics.
Rehabilitation of COVID patients on an outpatient basis
Authors:   Rauan Medical Group, Semey, Republic of Kazakhstan, Serikov N. , Yagofarov F.F. ,   Semey Medical University, Semey, Republic of Kazakhstan, Dyusupova A.A. ,   Semey Medical University, Semey, Republic of Kazakhstan, Kudaibergenova N.K. ,   Semey Medical University, Semey, Republic of Kazakhstan, Belyaeva T.M. ,   Semey Medical University, Semey, Republic of Kazakhstan, Terekhova T.I. ,   Semey Medical University, Semey, Republic of Kazakhstan, Terekhov D.V. ,   Semey Medical University, Semey, Republic of Kazakhstan, Abdrakhmanova G.Zh. ,   Semey Medical University, Semey, Republic of Kazakhstan, Faizova R.I. ,   Semey Medical University, Semey, Republic of Kazakhstan, Kozubaeva D.B. ,   Semey Medical University, Semey, Republic of Kazakhstan, Kamasheva G.T. ,   Semey Medical University, Semey, Republic of Kazakhstan, Turakhanova B.S. ,   Semey Medical University, Semey, Republic of Kazakhstan
Published: April 2023

Some COVID-19 patients develop post-COVID syndrome, in the pathogenesis of which there are disorders in the respiratory, immune, and nervous systems. The aim of the study was to evaluate the clinical efficacy of Alvenorm forte and Roncolekin® in patients with post -COVID syndrome undergoing outpatient rehabilitation. The studies were carried out in outpatient clinics in Semey from October 2021 to March 2022. The immunological studies were carried out in the laboratory of the Semey Med ical University. Methods: 26 patients with post-COVID syndrome and 30 donors were included in a controlled, open, non-randomized clinical trial. All patients received the drug Alvenorm forte daily for 30 days and Roncoleukin® 250,000 IU subcutaneously every three days (10-12 injections). The studies of the phenotype of blood cells were carried out by the ELISA method with a set of monoclonal antibodies. All patients with COVID-19 had shortness of breath, tachycardia, and neurological symptoms. High neutrophil count, leukopenia, lymphopenia, monocytopenia, a relative increase in T-helper cells, and a decrease in B and NK cells were observed in the blood. After the rehabilitation, dyspnea and tachycardia disappeared in most patients, with a significant decrease in neurological manifestations. After the rehabilitation, the main indicators of blood and immune status were restored. Conclusions: post-COVID syndrome was accompanied by shortness of breath, tachycardia, neurological symptoms, and immune deficiency. The use of Alvenorm forte and Roncoleukin® made it possible to stop respiratory and immune deficiency, tachycardia, and neurological symptoms. Our data are consistent with the results of immunorehabilitation.
Urinary tract infection and oxidative stress: pathogenetic parallels and possibilities of antioxidant support
Authors:   FSBEI HE Rostov State Medical University of the Ministry of Health of the Russian Federation, Letifov G. M.
Published: April 2023

Preservation of the normal microbiota of the mucous membranes of the genitourinary system becomes the leading factor in the reduction of pathogens and an obstacle to their entry into the urinary tract. Complete and adequate nutrition with the inclusion of essential food factors (vitamin and mineral complexes, unsaturated fatty acids), adaptogenic agents, and herbal extracts with antimicrobial action in the complex for the prevention, treat ment, and rehabilitation of diseases of the urinary system allows increasing the capabilities of the immune system, reducing oxidative stress, and carrying out anti-infective treatment more effectively. This approach is justified in order to achieve the main desired effect — a stable improvement in the quality of life of a patient with urinary system diseases.
Features of diagnosis and treatment of false post-traumatic diaphragmatic hernias
Authors:   Federal State Budgetary Educational Institution of Higher Education «Chita State Medical Academy» of the Russian Federation Ministry of Health, Chita, Russia, Bogomolov N. I. , Kashafeeva A. A. ,   Federal State Budgetary Educational Institution of Higher Education «Chita State Medical Academy» of the Russian Federation Ministry of Health, Chita, Russia
Published: April 2023

Damage to the diaphragm domes followed by the formation of false diaphragmatic hernias (FDH) occurs with closed and open trauma to the chest and/or abdomen. In this case, the mobile organs of the abdominal cavity, being uncovered by the parietal peritoneum, move to the pleural cavity and, with a small defect in the diaphragm, can be infringed up to necrosis of the organ wall. The rare occurrence of such pathology, the paucity of clinical symptoms, explains the high error rate in diagnosis, especially in primary health care. We have experience in two clinics over 34 years in the treatment of 12 patients with FDH. The left dome was damaged in 10 patients, the right dome in two. The age of damage to the diaphragm ranged from several hours to 7 years. Five clinical examples are presented, combined with the late diagnosis of the disease, the difficulties of diagnosis, even in a clinic using modern imaging tools. All patients are operated on both as planned and as an emergency. Endovideosurgical technologies for diagnosis and treatment are used only in 2 patients. 2 (16.67 %) patients died with a false diaphragmatic hernia due to a severe closed injury against the background of traumatic and hemorrhagic shocks. Conclusions. A clear explanation of the origin of scars on the skin of the chest and abdomen, clarification of the mechanisms and severity of closed injuries in the https://panor.ru/articles/osobennosti-diagnostiki-i-lecheniya-lozhnykh-posttravmaticheskikh-diafragmalnykh-gryzh/92437.html
False-positive symptoms of recurrence of gastroesophageal reflux disease (gerd) in patients with hiatal hernia (hh) after anti-reflux videolaparoscopy
Authors:   FSBEI HE Altai State Medical University of the Ministry of Health of the Russian Federation, Oskretkov V.I. , Tseimakh E.A. ,   FSBEI HE Altai State Medical University of the Ministry of Health of the Russian Federation, Andreasyan A.R. ,   FSBEI HE Altai State Medical University of the Ministry of Health of the Russian Federation, Grigoryan M.A. ,   FSBEI HE Altai State Medical University of the Ministry of Health of the Russian Federation, Maslikova S.A. ,   FSBEI HE Altai State Medical University of the Ministry of Health of the Russian Federation
Published: April 2023

We compared the results of remote survey of 213 patients with HH associated with GERD in the long term after anti-reflux videolaparoscopy, according to the GERD-HRQL, GIQLI, and SF-36 questionnaires (patients’ complaints) and special methods for studying the anti-reflux function of the cardia (X-ray endoscopy of the esophagus and stomach, daily esophageal pH monitoring, esophageal manometry). Based on the results of special studies, a generalized indicator of failure of the anti-reflux function of the cardia (GIFAFC) was developed. It was found that 57.3% of the examined patients had false-positive symptoms of GERD recurrence, which was manifested by pain in the epigastric region (31.2%), belching with air (4.1%), and heartburn (21.3%). There were no symptoms when bent over or lying down. The existing symptoms were mild, easily stopped by conservative treatment. The patients with false-positive GERD symptoms after surgery showed an improvement in GIFAFC by 7.9 times (p <0.001), but it was 5.4 times worse than in patients without recurrent GERD (p <0.001), and 6.3 times better in relation to patients with recurrent GERD (p<0.05). False-positive symptoms of GERD recurrence contributed to a decrease in the generalized indicator of quality of life, which, according to the SF-36 questionnaire, was 76% of the maximum desired result. Due to the absence of reliable clinical manifestations, all patients with HH who have certain symptoms of GERD after fundoplication should undergo an instrumental study of the anti-reflux function of the cardia. Patients with established false-positive symptoms of GERD are subject to dispensary follow-up.
New approaches to the initial measurement of intangible assets in accounting: significant changes, problems and ways to solve them
Authors:   Federal State Autonomous Educational Institution of Higher Education “Lobachevsky State University of Nizhny Novgorod”, Nizhny Novgorod, Russia, Druzhilovskaya E.S.
Published: April 2023

Currently, the process of reforming Russian accounting is ongoing. The measurement of intangible assets is no exception. The relatively recently approved Federal Accounting Standard (FAS) 14/2022 “Intangible Assets” by the Ministry of Finance of the Russian Federation provides that the initial measurement of such assets will be carried out in accordance with FAS 26/2020 “Capital Investments”. The latter, in turn, was recently amended, making significant adjustments to the definition of this measurement. FAS 14/2022 and amendments to FAS 26/2020 are mandatory to come into effect from 2024. But their early application is also allowed by the decision of the organization. In addition, in order to prepare for future adjustments introduced by these standards, it is necessary to analyze the relevant changes now. In this article, we explore new approaches to the initial measurement of intangible assets in accounting. Other innovations of FAS 14/2022 and FAS 26/2020 will be analyzed by us in other works. As research methods, we used analysis and synthesis, comparison, grouping method, analogy method, logical approach, systematic approach. As a result of the research, all innovations in the field of the initial measurement of intangible assets are grouped by us into several groups, within which the main problematic issues due to the expected changes are identified. For each of these issues, we present proposals for their solution. The results presented in this paper will be useful to a wide range of readers interested in accounting issues, including the initial measurement of intangible assets, can be used in the educational process of higher educational institutions, in the practical work of accounting departments, as well as in the development and improvement of relevant regulatory documents on accounting.
Stabilizing Li2O-based Cathode/Electrolyte Interfaces through Succinonitrile Addition
Authors: Joo Myeong Jun , Park Yong Joon
Published: April 2023

Li2O-based cathodes utilizing oxide–peroxide conversion are innovative next-generation cathodes that have the potential to surpass the capacity of current commercial cathodes. However, these cathodes are exposed to severe cathode–electrolyte side reactions owing to the formation of highly reactive superoxides (Ox−, 1 ≤ x < 2) from O2− ions in the Li2O structure during charging. Succinonitrile (SN) has been used as a stabilizer at the cathode/electrolyte interface to mitigate cathode–electrolyte side reactions. SN forms a protective layer through decomposition during cycling, potentially reducing unwanted side reactions at the interface. In this study, a composite of Li2O and Ni-embedded reduced graphene oxide (LNGO) was used as the Li2O-based cathode. The addition of SN effectively thinned the interfacial layer formed during cycling. The presence of a N-derived layer resulting from the decomposition of SN was observed after cycling, potentially suppressing the formation of undesirable reaction products and the growth of the interfacial layer. The cell with the SN additive exhibited an enhanced electrochemical performance, including increased usable capacity and improved cyclic performance. The results confirm that incorporating the SN additive effectively stabilizes the cathode–electrolyte interface in Li2O-based cathodes.
Tangent to the Earth: Tracking Site Conditions According to Horizontal Solar Light
Authors:   Texas Tech University, McReynolds Victoria
Published: April 2023

“Red sky at night, sailor’s delight. Red sky in the morning, sailor take warning.” As the adage above suggests, sunrise and sunset, when light passes along tangent to the surface of earth, are optimum times of the day to “read” the sky and realize thermodynamic properties influencing a site. Solar light arriving tangent to the Earth travels through roughly forty-five times more troposphere (figure 1) on its way to reaching a site and, most likely, will have encountered various clouds, particulates, and pollutants along the way. We experience these dynamic moments, the last of visible light (figure 2), as perceptual shifts in our environment, and physiological shifts in our eyes as cones and rods tradeoff absorption responsibility of the electromagnetic spectrum1. The qualitative measurement of light tangent to Earth’s surface is inevitably more than the altitude and azimuth reading of solar light. Site tracking during sunrise or sunset draws together often separate analysis of meteorological and terrestrial features towards an environmental ecology.
Formation of neuron-microelectrode junction mediated by a synapse organizer
Authors: Kim Samyoung , Imayasu Mieko , Yoshida Tomoyuki , Tsutsui Hidekazu
Published: April 2023

Neural circuits are composed of various cell types, each of which is thought to play a specific role in realizing the circuit functions. Cell-type specificity is therefore essential in recording neuronal activities but is inherently lacking in the currently available microelectrode techniques. Here, using Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1) as a model synapse organizer, we show a proof-of-principle experiment that a microelectrode functionalized with a synapse organizer is capable of inducing a synapse-like junction between a neuron upon physical contact. We then discuss prospects for developing a new mode of electrophysiology that permits cell-type specific recordings via such a molecularly induced neuron-microelectrode junction.
Pelatihan Berfikir Positif untuk Meningkatkan Kepercayaan Diri Remaja Yatim Pondok Pesantren X Di Palembang
Authors: Afifah kamilah  , Abdullah Sri Muliati
Published: April 2023

Penelitian ini bertujuan untuk mengetahui perbedaan tingkat kepercayaan diri pada remaja yatim sebelum dan sesudah diberikan pelatihan berpikir positif. Metode yang digunakan dalam penelitian ini adalah metode eksperimen dan diukur sebanyak tiga kali (pretest, posttest, dan follow up dalam 10 hari setelah perlakuan). Subjek penelitian ini berjumlah 18 orang remaja yatim dan memiliki skor berpikir positif dan kepercayaan diri yang rendah, subjek terbagi menjadi 2 kelompok yaitu kelompok eksperimen dan kelompok kontrol. Pembagian kedua kelompok tersebut dilakukan dengan cara random assigment. Kelompok eksperimen diberikan perlakuan berupa intervensi pelatihan berpikir positif yang dilakukan selama 3 hari. Kelompok kontrol mendapatkan perlakuan setelah follow up dilakukan. Skala berpikir positif dan kepercayaan diri digunakan sebagai alat ukur dalam penelitian. Hasil analisis data yang dilakukan menggunakan teknik analisis Mann Whitney U-Test didapatkan hasil, skor post test antara kelompok eksperimen dengan kelompok kontrol sebesar Z -3,582 dengan Asymp. Sig sebesar (p=0,000<0.05), dimana terdapat perbedaan skor kepercayaan diri setelah diberikan intervensi pelatihan berpikir positif dibandingkan dengan kelompok kontrol yang tidak diberikan intervensi. Tingkat kepercayaan diri kelompok eksperimen setelah diberikan intervensi lebih tinggi dibandingkan dengan kelompok kontrol. Berdasarkan hasil analisis diatas dapat disimpulkan bahwa pelatihan berpikir positif efektif dalam meningkatkan kepercayaan diri pada remaja yatim.

 

Kata kunci: Pelatihan berpikir positif, Kepercayaan diri, Remaja yatim
Educazionale
Authors: Rainer Franz
Published: April 2023

Alcuni lettori domandano se si possa usare legittimamente l’aggettivo educazionale.
Fitness-to-Practise: How UK Healthcare Regulators Cause Practitioner Deaths
Authors: Macqueen Dominic
Published: April 2023

Cases of practitioner ill-health and suicide have been attributed to disciplinary proceedings carried out by healthcare regulators. The methods operated by regulatory bodies when investigating claims of practitioner wrongdoing exhibit judicial irregularities and raise significant ethical concerns. Revealing how and where regulators fail to execute their fitness-to-practise responsibilities constructively creates a starting point from which fairer and safer systems of regulatory interventions can be considered. This paper is an analysis of how the regulatory establishment administers fitness-to-practise procedures, and endeavours to identify how existing approaches cause harm and undermine the integrity of regulatory oversight.
ASSOCIATION BETWEEN ATP1A1 GENE POLYMORPHISMS WITH SEMEN CHARACTERISTICS IN HOLSTEIN BULLS
Authors: S. M. Eidan  , S. A. Khudhir
Published: April 2023

This study was conducted to identify the polymorphism of ATP1A1 gene, distribution ratios, and its association with semen characteristics of Holstein bulls. Twenty-five Holstein bulls were used currently. Blood samples were collected via venipuncture to separate the DNA and identify the polymorphism of the ATP1A1 gene. Semen was collected using an artificial vagina for fresh evaluation. Results were showed the change of cytosine (C) nucleotide at site 15738 to adenine (A) at the exon 17 (SNP C15738A) of the ATP1A1 gene. Two polymorphisms were obtained according to this change, the first is wild (CC; allele frequency 0.84), and the second is heterogeneous (CA; allele frequency 0.16). The CC polymorphism of the ATP1A1 gene exhibited a highly significant (p<0.01) superiority for ejaculate volume, sperm concentration, and mass activity, and for sperm’s cell individual motility (p<0.05), compared with the CA polymorphism of Holstein bulls. The other semen characteristics did not differ between the two mentioned polymorphisms. This polymorphism exhibited obvious semen characteristics despite stress conditions of feed shortage and poor management practices accompanied with the covid-19 pandemic. This gene can be used to predict the fertility and stress resistance of bulls before they reach sexual maturity and its reflection on the economic return of breeding these bulls at the artificial insemination centers.
POTENTIAL OF CHITOSAN IN REDUCING GA3 DOSES AND THEIR EFFECT ON GROWTH, YIELD, AND BULB QUALITY IN “GIZA RED” ONION
Authors: Alaa El-Den H. R.  , A. A. Khadr
Published: April 2023

Tow field experiments were conducted during the seasons of 2020/2021 and 2021/2022 at the experimental farm Etay El-Baroud research station to investigate the effect of foliar application with gibberellic acid (GA3) at 50 and 100 ppm and the chitosan (CS) at of 100 and 200 ppm, in addition, to control for each to Giza Red onion. The results showed significant and positive effects of the examined concentrations of GA3 or CS on all the studied characters except leaves number and shape index, in both seasons. Concerning the interaction effect, all of the studied characters were enhanced significantly in all treatment combinations between GA3 and CS levels. The treatments of GA3 (50 ppm) with CS (200 ppm), GA3 (100 ppm) with CS (100 ppm), and GA3 (100 ppm) with CS (200 ppm) were found to give the highest mean values for all characters, in both seasons without significant differences among them. Also, the results revealed some kind of synergistic effect between GA3 and CS where the combined application was found to be more effective in onion plants performance thane the single ones that gave the ability to reduce the used doses of GA3 by 50%, which, consequently, reduce the expected hazardous of using gibberellins.
Emergent Causality & the Foundation of Consciousness
Authors: Bennett Michael Timothy
Published: April 2023

Awarded "Best Student Paper" and published in Proceedings of The 16th International Conference on Artificial General Intelligence, Stockholm, 2023.

To make accurate inferences in an interactive setting, an agent must not confuse passive observation of events with having intervened to cause them. The do operator formalises interventions so that we may reason about their effect. Yet there exist pareto optimal mathematical formalisms of general intelligence in an interactive setting which, presupposing no explicit representation of intervention, make maximally accurate inferences. We examine one such formalism. We show that in the absence of a do operator, an intervention can be represented by a variable. We then argue that variables are abstractions, and that need to explicitly represent interventions in advance arises only because we presuppose these sorts of abstractions. The aforementioned formalism avoids this and so, initial conditions permitting, representations of relevant causal interventions will emerge through induction. 

These emergent abstractions function as representations of one’s self and of any other object, inasmuch as the interventions of those objects impact the satisfaction of goals. We argue that this explains how one might reason about one's own identity and intent, those of others, of one's own as perceived by others and so on. In a narrow sense this describes what it is to be aware, and is a mechanistic explanation of aspects of consciousness.
On the Computation of Meaning, Language Models and Incomprehensible Horrors
Authors: Bennett Michael Timothy
Published: April 2023

Accepted for full oral presentation at the 16th Conference on Artificial General Intelligence, taking place in Stockholm, 2023.

We integrate foundational theories of meaning with a mathematical formalism of artificial general intelligence (AGI) to offer a comprehensive mechanistic explanation of meaning, communication, and symbol emergence. This synthesis holds significance for both AGI and broader debates concerning the nature of language, as it unifies pragmatics, logical truth conditional semantics, Peircean semiotics, and a computable model of enactive cognition, addressing phenomena that have traditionally evaded mechanistic explanation. By examining the conditions under which a machine can generate meaningful utterances or comprehend human meaning, we establish that the current generation of language models do not possess the same understanding of meaning as humans nor intend any meaning that we might attribute to their responses. To address this, we propose simulating human feelings and optimising models to construct weak representations. Our findings shed light on the relationship between meaning and intelligence, and how we can build machines that comprehend and intend meaning.
Awesome-META+: Meta-Learning Research and Learning Platform
Authors: Wang Jingyao , Zhang Chuyuan , Ding Ye , Yang Yuxuan
Published: April 2023

 Artificial intelligence technology has already had a profound impact in various fields such as economy, industry, and education, but still limited. Meta-learning, also known as "learning to learn", provides an opportunity for general artificial intelligence, which can break through the current AI bottleneck. However, meta learning started late and there are fewer projects compare with CV, NLP etc. Each deployment requires a lot of experience to configure the environment, debug code or even rewrite, and the frameworks are isolated. Moreover, there are currently few platforms that focus exclusively on meta-learning, or provide learning materials for novices, for which the threshold is relatively high. Based on this, Awesome-META+, a meta-learning framework integration and learning platform is proposed to solve the above problems and provide a complete and reliable meta-learning framework application and learning platform. The project aims to promote the development of meta-learning and the expansion of the community, including but not limited to the following functions: 1) Complete and reliable meta-learning framework, which can adapt to multi-field tasks such as target detection, image classification, and reinforcement learning. 2) Convenient and simple model deployment scheme which provide convenient meta-learning transfer methods and usage methods to lower the threshold of meta-learning and improve efficiency. 3) Comprehensive researches for learning. 4) Objective and credible performance analysis and thinking. 
Astrocytes induce desynchronization and reduce predictability in neuron-astrocyte networks cultured on microelectrode arrays
Authors: Genocchi Barbara , Ahtiainen Annika , Niemi Annika , Barros Michael , Tanskanen Jarno , Lenk Kerstin , Hyttinen Jari , Subramaniyam Narayan
Published: April 2023

In this work, we aim to study how astrocytes control electrophysiological activity during network formation. Here we use a combination of spike/burst analysis and complex analysis of the raw neuronal signals to assess the role of astrocytes on microelectrode arrays (MEA). We cultured rat primary cortical neurons and astrocytes on 60-electrode MEAs with different neuron/astrocyte ratios ranging from “pure” neuronal cultures (NS) without separately added astrocytes to co-cultures containing 50% neurons and 50% astrocytes. We analyzed the spike and burst rates, as well as the complexity-entropy causality planes of the signals to deeply study the patterning of the neuronal signals.

Moreover, we classified the spike waveforms from the NS and the co-cultures based on their signal properties, and we predicted the signals in the co-cultures with a Random Forest regressor.

The dataset used can be found at: https://zenodo.org/record/7741379.