bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation of the Impact of SARS-CoV-1 Infection on the Immunologic Status and Lung Function After 15 Years
Authors: Li Jia , Zheng Yali , Zhao Lili , Yue Zhihong , Pan Feng , Chen Yuehong , Yu Bing , Chen Yanwen , Zhao Guangyu , Zhou Yusen , Gao Zhancheng
Published: May 2021

Background: To investigate the long-term effects of SARS-CoV-1 on patients’ lung and immune systems 15 years post-infection. Methods: We enrolled 58 health care workers with confirmed SARS in Peking University People’s Hospital in 2003. We evaluated lung damage by mMRC score, pulmonary function tests, and chest CT. Immune function was assessed by their serum levels of globin, complete components, and peripheral T cell subsets. ELISA was used to detect SARS-CoV-specific IgG antibodies in sera. Results: After 15 years of disease onset, 19 (36.5%), 8 (34.6%), and 19 (36.5%) subjects had impaired DL(CO), RV, and FEF25-75, respectively. 17 (30.4%) subjects had an mMRC score ≥ 2. Fourteen (25.5%) cases had residual CT abnormalities. T regulatory cells were a bit higher in the SARS survivors. IgG antibodies against SARS S-RBD protein and N protein were detected in 11 (18.97%) and 12 (20.69%) subjects, respectively. Subgroup analysis revealed that small airway dysfunction and CT abnormalities were more common in the severe group than in the non-severe group (57.1% vs 22.6%, 54.5% vs 6.1%, respectively, p < 0.05). Conclusions: SARS-CoV-1 could cause permanent damage to the lung, which requires early pulmonary rehabilitation. The long-lived immune memory response against coronavirus requires further studies to assess the potential benefit.Trail registration: ClinicalTrials.gov, NCT03443102. Registered prospectively on 22/02/2018.
Impact of integrative open dialogue about complementary alternative medicine. A phase II randomized controlled trial
Authors: Stie Mette , Delmar Charlotte , Nørgaard Birgitte , Jensen Lars Henrik
Published: May 2021

Complementary alternative medicine (CAM) may reduce the symptom burden of side effects to antineoplastic treatment but also cause new side effects and non-adherence to conventional treatment. The aim of this randomized controlled study was to investigate the impact of integrative open dialogue about CAM (IOD-CAM) on cancer patients’ health and quality of life (QoL). Patients undergoing curative or palliative antineoplastic treatment were randomly assigned to standard care (SC) plus IOD-CAM or SC alone. A nurse specialist facilitated IOD-CAM in one or two sessions. The primary endpoint was the frequency of grade 3–4 adverse events (AE) eight weeks after enrollment. Secondary endpoints were frequency of grade 1–4 AE and patient reported QoL, psychological distress, perceived information, attitude towards and use of CAM 12 and 24 weeks after enrollment. Survival was analyzed post-hoc. Fifty-seven patients were randomized to IOD-CAM and 55 to SC. No significant difference in frequency of grade 3–4 AEs was shown between the two groups eight weeks after enrollment. The same applied to grade 1–4 AE and QoL, psychological distress, and perceived information 12 and 24 weeks after enrollment. However, a tendency towards better QoL, improved survival, and lower level of anxiety was found in the IOD-CAM group. IOD-CAM is not superior to SC in reducing frequency of AEs in patients undergoing oncology treatment. IOD-CAM does not compromise patient safety; it may reduce psychological stress, and improve QoL and overall survival. Further research on the effect of IOD-CAM on emotional well-being and overall survival is warranted.
Assess transmissibility of different influenza subtypes: Based on a SEIABR model
Authors: Dai Haoyun , Zhou Nan , Chen Mengxiang , Li Guoqun , Yi Shanghui , Hong Xiuqin , Quan Meifang , Zha Wen-Ting , Lv Yuan
Published: May 2021

Background: Influenza is a worldwide public health problem which causes a serious economic and health burden. In order to provide a scientific basis for improving the prevention and control level of influenza, using dynamic model to evaluate the infection rates of influenza different subtypes from 2010 to 2019 in China. Methods: This article established SEIABR model and calculated the infection rates of different influenza subtypes by using the Berkeley Madonna software. Results: The average infection rate of influenza was (7.95±1.27)×10-10 , and influenza A was (7.25±0.82) ×10-10, influenza B was (5.88±0.97)×10-10. In addition, the infection rates of A /H1N1, A/H3N2, B/Yamagata and B/Victoria were (7.25±0.82) ×10-10, (6.13±0.35) ×10-10, (6.01±0.52) ×10-10, (6.37±0.79) ×10-10. Conclusion: Between each year, flu transmission capacity had fluctuation. Influenza A was more transmissible than influenza B, and during the major subtypes, influenza A/H1N1 was the most transmissible.
A Case of Synchronous Serous Ovarian Cancer and Uterine Serous Endometrial Intraepithelial Carcinoma
Authors: Shimizu Maho , Yamanaka Keitaro , Azumi Maho , Tomimoto Masako , Washio Keiichi , Takahashi Ryosuke , Nagamata Satoshi , Murata Yuka , Yamasaki Yui , Terai Yoshito
Published: May 2021

BackgroundSerous endometrial intraepithelial carcinoma (SEIC) is now considered to represent an early stage of uterine serous carcinoma (USC). It is an intraepithelial lesion but has been reported to cause extrauterine metastases. We report a case of SEIC with serous ovarian carcinoma and lymph node metastasis.Case presentationA 57-year-old post-menopausal woman (gravida 3, para 2, SA1) was referred to our hospital with lower abdominal pain. An ultrasound and MRI showed that the ovary had swollen to 8 cm in size and had a solid lesion. The uterus was normal. The patient underwent exploratory laparoscopy on the suspicion of torsion of the ovarian tumor. Intraoperative findings showed a right ovarian tumor, but no ovarian tumor torsion was observed. A small amount of bloody ascites was found in the Douglas fossa, and bleeding was observed from the tumor itself. A right salpingo-oophorectomy was then performed. Histopathological results revealed a high-grade serous carcinoma. Forty days after the first surgery, we performed a staging laparotomy: a total abdominal hysterectomy, left salpingo-oophorectomy, systematic pelvic and paraaortic lymphadenectomy, and a partial omentectomy. A complete cytoreduction was achieved. In the pathological examination, the invasion of the serous carcinoma was observed in the left ovarian ligament, and lymph node metastasis was found in the paraaortic lymph nodes. Atypical columnar cells formed irregular papillary lesions which had proliferated in the endometrium, and this was diagnosed as SEIC. The final diagnosis was serous ovarian cancer, FIGO stage ⅢA1(ⅱ), pT2bN1M0, with SEIC. ConclusionWe report a case of SEIC with synchronous serous carcinoma of the adnexa uteri. Both were serous carcinomas and, thus, it was difficult to identify the primary lesion. The distinction between metastatic cancer and two independent primary tumors is important for an accurate diagnosis and tumor staging. Histological diagnostic criteria remain controversial, and further development of a method for differentiating between both diseases is required.
The Multidisciplinary Treatment of Advanced Gallbladder Cancer to Disease-Free Survival: A Case Report
Authors: Zhang Biao , Li Shuang , Liu Zhaoyi , Peiris Karieshinie Ghandalie Kalandika , Song Lifu , Liu Mucang , Luo Peng , Shang Dong , Bi Wei
Published: May 2021

Background: Gallbladder cancer is the most common malignant tumor in the biliary system and is characterized by strong aggressiveness and an extremely poor prognosis. Current treatment for advanced gallbladder cancer remains unsatisfactory. Here we reported a patient with stage IV gallbladder cancer who achieved disease-free survival by multidisciplinary treatment.Case presentation: A 73-year-old man presented to our hospital with right abdominal pain for 3 days and was diagnosed with advanced gallbladder cancer with multiple intrahepatic metastases and distant lymph node metastases. The patient initially received chemotherapy, targeted therapy, radioactive seed implantation, and immunotherapy as there was no specific indications for radical surgery. With the progression of these adjuvant therapies, the patient’s tumor makers gradually decreased but remained higher than normal, lymph node metastases gradually disappeared, and intrahepatic metastases were gradually limited to the left liver. Finally, the patient received a radical surgery of left hepatectomy with partial diaphragmatic resection and radical lymphadenectomy. To date, the patient has survived for more than six years post-treatment, and the level of tumor markers is normal and the imaging examination shows no signs of disease recurrence.Conclusion: The treatment of advanced gallbladder cancer remains pessimistic in the current medical arena. This successful case is an inspiration and we believe that multidisciplinary treatment can benefit patients with advanced gallbladder cancer and help them achieve long-term survival or even disease-free survival.
The Giant Parathyroid Adenoma Reaching Mediastinum: A Case Report
Authors: Mahmodlou Rahim , Sedokani Amin , Najafinejad Bita
Published: May 2021

Background: The primary hyperparathyroidism is the most common disease of parathyroid glands and the third common endocrine disease. Giant parathyroid adenoma is defined as weight > 3.5gr and size of > 2cm, however, the normal weight of the parathyroid gland is about 70mg to 1gr.Case Presentation: This report describes the most giant diagnosed primary parathyroid adenoma due to literature. The case is a 48-year-old Persian man with past medical history of mitral valve replacement and several episodes of bilateral nephrolithiasis. The chief complaints were knee and lower back pain. After complete assessment, the neck mass with possible origin of thyroid were detected and resected by surgery. The size of resected mass was 9×6×4cm weighting 122gr. The histopathological assessment revealed giant parathyroid adenoma.Conclusion: There are some reports of giant parathyroid adenoma describing the weight of up to 110gr leading to significant hypercalcemia with a size of 8cm. despite the size of the giant parathyroid adenomas and parathormone high levels, the calcium crisis may not always occur in these patients and the masses may be misdiagnosed with thyroid mass at primary assessments.
MRI Modality-based Brain Tumor Segmentation Using Deep Neural Networks
Authors: Kasar Pankaj Eknath , Jadhav Shivajirao M. , Kansal Vineet
Published: May 2021

The tumor detection is major challenging task in brain tumor quantitative evaluation. In recent years, owing to non-invasive and strong soft tissue comparison, Magnetic Resonance Imaging (MRI) has gained great interest. MRI is a commonly used image modality technique to locate brain tumors. An immense amount of data is produced by the MRI. Heterogeneity, isointense and hypointense tumor properties restrict manual segmentation in a fair period of time, thus restricting the use of reliable quantitative measures in clinical practice. In the clinical practice manual segmentation task is quite time consuming and their performance is highly depended on the operator’s experience. Accurate and automated tumor segmentation techniques are also needed; however, the severe spatial and structural heterogeneity of brain tumors makes automatic segmentation a difficult job. This paper proposes fully automatic segmentation of brain tumors using encoder-decoder based convolutional neural networks. The paper focuses on well-known semantic segmentation deep neural networks i.e., UNET and SEGNET for segmenting tumors from Brain MRI images. The networks are trained and tested using freely accessible standard dataset, with Dice Similarity Coefficient (DSC) as metric for whole predicted image i.e., including tumor and background. UNET’s average DSC on test dataset is 0.76 whereas for SEGNET we got average DSC 0.67. The evaluation of results proves that UNET is having better performance than SEGNET.
Numerical dissipation of flux splitting schemes for contact discontinuities
Authors: Liu Jun , Han Fang , Wei Yan Xin
Published: May 2021

The contact discontinuity is simulated by three kinds of flux splitting schemes to evaluate and analyse the influence of numerical dissipation in this paper. The numerical results of one-dimensional contact discontinuity problem show that if the flow velocity on both sides of the contact discontinuity is not simultaneously supersonic, the non-physical pressure and velocity waves may occur when the initial theoretically contact discontinuity is smeared into a transition zone spanning several grid-cells caused by numerical dissipations. Since these non-physical waves have no effect on the corresponding density dissipation, this paper considers these fluctuations as only numerical errors and are not part of the numerical dissipation. In addition, for two-dimensional flow field, the characteristics of high-order accuracy difference schemes, i.e. low dissipation and high resolution, may induce the multi-dimensional non-physical waves that interfere with each other to produce more complex non-physical flow structures, so the fluctuations in the calculated results should be treated with caution.
The Antioxidant tempol delays the MIA-induced osteoarthritis progression in rats via modulation of signaling pathways involving TGF-β1/SMAD3/NOX4 axis
Authors: Abo-zalam Hagar B. , Abdel-Rahman Rehab F. , Abd-Ellah Mohamed F. , Abdalsalam Rania M. , Khattab Mahmoud M.
Published: May 2021

Osteoarthritis (OA) is a complex disease characterized by structural, functional, and metabolic deteriorations of the whole joint and periarticular tissues. In the current study, we aimed to investigate the possible effects of tempol on knee OA induced by the chemical chondrotoxic monosodium iodoacetate (MIA) which closely mimics both the pain and structural changes associated with human OA. Rats were administrated oral tempol (100 mg/kg) one week post-MIA injection (3 mg/ 50 μL saline) at the right knee joints for 21 consecutive days. Tempol improved motor performance and debilitated the MIA-related radiological and histological alterations. Besides, it subsided the knee joint swelling. Tempol decreased the cartilage degradation-related biomarkers as matrix metalloproteinase-13, cartilage oligomeric matrix protein, and fibulin-3. The superoxide dismutase mimetic effect of tempol was accompanied by decreased NADPH oxidase 4 (NOX4), inflammatory mediators, nuclear factor kappa-B (NF-κB), over-released insulin-like growth factor-1 (IGF-1) and transforming growth factor-β1 (TGF-β1). Tempol decreased the expression of chemotactic cytokine ligand 2 (CCL2), dickkopf‑related protein-1 (DKK-1), and protein kinase C (PKC). On the molecular level, tempol reduced the phosphorylated protein levels of p38 mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K), protein kinase B (Akt), and small mother against decapentaplegic 3 homologs (SMAD3). These findings suggest the promising role of tempol in ameliorating MIA-induced knee OA in rats via collateral suppression of the catabolic signaling cascades including TGF-β1/SMAD3/NOX4, NOX4/p38MAPK/NF-κB, and PI3K/Akt/NF-κB and therefore modulation of oxidative stress, catabolic inflammatory cascades, chondrocyte metabolic homeostasis, autophagy, and cell survival.
Accurate localization of the symptomatic nerve roots of patients with adult degenerative scoliosis using diffusion tensor imaging
Authors: Wang Qian , Gao Peng , Tang Pengyu , Chen Jian , Zhao Shujie , Li Qingqing , Zhou Wei , Yin Guoyong , Fan Jin
Published: May 2021

Background: In the diagnosis and treatment of adult degenerative scoliosis (ADS), the localization of symptomatic nerve roots is mainly based on the symptoms and signs of patients. Because of spinal rotation deformity, conventional MRI cannot accurately select the level of intervertebral disc for scanning. In the present study, MR diffusion tensor imaging (DTI) was used to diagnose symptomatic nerve roots in patients with ADS, and its effectiveness was evaluated by comparing with diagnosis based on symptoms and signs of nerve root block. Methods: Thirty-six patients who were clinically diagnosed to have ADS underwent routine MRI and DTI examinations, and fractional anisotropy (FA) of each nerve root in the lumbar spine was quantitatively measured. The t-test was used to compare the FA values ​​of nerve roots with and without neurological symptoms. Preoperative and postoperative clinical evaluations were conducted on the patients, and the t-test was used to evaluate the clinical effects of surgery. Results: The FA values ​​of symptomatic and asymptomatic nerve roots were significantly different (P<0.01). The DTI findings of symptomatic nerve roots were consistent with the diagnosis based on symptoms and nerve root block. The Japanese Orthopaedic Association (JOA), Oswestry Disability Index (ODI), Visual Analog Scale-Back Pain (VAS-BP), and Visual Analog Scale-Leg Pain (VAS-LP) scores of the postoperative patients were significantly improved as compared to those in the preoperation stage; the Cobb, Lumbar Lordosis (LL), Pelvic Tilt (PT), and Sacral Slope (SS) angles were corrected significantly post operation. Conclusion: The FA value can be used as a marker for predicting symptomatic nerve root and is consistent with clinical symptoms. According to the results of DTI, precise nerve root decompression can relieve the symptoms. Therefore, DTI can be used as an effective auxiliary method for symptomatic nerve root localization in patients with degenerative scoliosis.
PAVEMENT TYPE SELECTION FOR DEVELOPING COUNTRIES APPLYING LIFE CYCLE COST ANALYSIS
Authors:   Lecturer, Department of Civil Engineering, CUET, Bangladesh., Khan Azam , Omar Imam Mahmood ,   Professor, Department of Civil Engineering, CUET, Bangladesh.
Published: May 2021

Road network acts as a vein for the socio-economicdevelopment of a country. To maintain sustainable development,countries all over the world are investing heavily in road network infrastructure development. Bangladesh, an essential partner of the Asian Highway, is alsoinvesting heavily in road network development. But due to poorplanning, inefficient implementing agencies, inadequate pavementdesign, low-quality construction practices, lack of pavementmaintenance, rampant overloading & tropical climaticconditions, the investment is not yielding the desired result. In Bangladesh, the current trend of pavement construction is 95% flexible pavement [16]. Due to tropical climatic conditions & regular flash floods during the rainy season, water stagnation damages the flexible pavements severely. The rigid pavement has a high potential of survivability against the damage due to water stagnation. In Bangladesh, the transportation agencies emphasize on least initial construction cost rather thanthe least Life Cycle Costas the only tool for pavement type selection. Due to low initial construction cost, the flexible pavement always gets priority over the rigid pavement. In this research, Life Cycle Cost Analysisof flexible and rigid pavement had been done for Sylhet-Bholagajroad comprising of both rigid & flexible portions. The pavement design data & different Schedule of Rates collected from the Roads and Highways Departmenthad been used for this analysis. 12% discount rate was used to convert all estimated future costs to Net Present Value. After performing a life cycle cost analysis, it can be concluded that rigid pavement is the optimal choice of pavementfor developing countries like Bangladesh.
MAGNETIC AND ELECTRONIC SPECTRAL STUDIES OF FOUR, FIVE AND SIX COORDINATED COMPLEXES OF SUBSTITUTED HYDRAZIDE AND HYDRAZONES WITH DIVALENT NICKEL AND COBALT METAL IONS
Authors:   PGT Chemistry, Meerut Public School, Meerut., Bhardwaj Saurabh , Saraswat Renu ,   Associate Professor, Department of Chemistry, Meerut College, Meerut., Chatterji Nupur ,   Associate Professor, Department of Chemistry, Meerut College, Meerut.
Published: May 2021

Metal complexes of divalent Nickel and Cobalt metal ions have been synthesized with picolinic acid hydrazide (PH) , ortho -hydroxy acetophenone picolinoyl hydrazone ( APH) and ortho-hydroxy acetophenone iso-nicotinoyl hydrazone (AIH) ligands and were isolated at both high pH and low pH. These complexes were characterized by elemental analyses and also by electronic spectral studies and magnetic measurements. Ligands PH and AIH act as tridentate, while APH is tetradentate. All form two types of complexes, depending upon pH of the reaction mixture. At high pH complexes formed are monomeric while at high pH complexes were found to be dimeric. Dimerisation is initiated by enolic oxygen which acts like a bridging ligand between two metal ions.
AGING ANXIETY: A STUDY OF FACTOR INFLUENCING ATTITUDES TO AGE AMONG CIVIL SERVANTS IN NIGERIA
Authors:   Federal College of Education, Eha Amufu, Enugu State, Nigeria., a Pauline , Ikwuegbu N. ,   Federal College of Education, Eha Amufu, Enugu State, Nigeria., Omatalu Daniel ,   Department of Educational Psychology, Federal College of Education, Eha Amufu, Enugu State, Nigeria.
Published: May 2021

The present study aimed to examine religious commitment as a scarcely explored variable that could predict aging attitudes. The study adopted a cross-sectional survey. A total of one hundred and eighty-seven civil servants were randomly selected as the research participants. The respondents completed self-report measures of religious commitment scale and attitude to owns aging scale. A linear regression analysis was performed on the data, and the result revealed a significant association between religious commitment and attitude towards aging. It was indicating that religious commitment predicted attitude towards aging. The research finding, implications, and conclusions are discussed.
ASSESSING THE PHYTOCHEMICAL CONTENTS AND ANTIMICROBIAL ACTIVITY OF BITTER LEAF (VERNONIA AMYGDALINA) ON MICRO-ORGANISMS
Authors:   Department of Chemistry, Kogi State College of Education, Ankpa., Omachi Andrew
Published: May 2021

Medicinal plants have assumed the basis of traditional medicine and have proven effective in human health care across the world. There is a growing interest in the role of complementary and alternative medicines to treat various illnesses. The continued consumption of antibiotic with little or no impact on bacteria have negatively affected health care delivery. Bitter leaf (Vernonia amygdalina) is a popular shrub belonging to the family Asteraceae and a perennial shrub commonly cultivated as a homestead vegetable and fodder tree in various parts of Nigeria. The current study was conducted to assess the phytochemical constituents and antimicrobial activity of bitter leaf on Candida albicans, Pseudomonas aeruginosa and Staphylococcus aureus. The result of the phytochemical analysis conducted on the root and stem bark of V. amygdalina revealed the presence of alkaloids, tannin, steroids, flavonoids, phenol, and saponins. However, it was found that tannins and phenol were mainly deposited in the plants stem bark.Also, the antimicrobial analysis conducted revealed that S. aureus was more vulnerable to the ethanol, acetone, and hot aqueous extracts of V. amygdalina. while, P. aeruginosa, and C. Albicans showed sensitivity to ethanol and acetone exposure but failed to react to the hot aqueous extracts.The study concludes that the observed biological reactions shown by the aqueous extracts of V. amygdalina corroborate the traditional application of this plant as an alternative antibiotic.
CUSTOMARY LAW IN NIGERIA AND PARENTAL PERCEPTION OF RIGHT OF THE CHILD
Authors:   Department of Fine and Applied Art, Federal College of Education, Eha Amufu, Enugu State, Nigeria., a Musa , Yahaya B. ,   Department of Fine and Applied Art, Federal College of Education, Eha Amufu, Enugu State, Nigeria., N. Samu Theresa ,   Department of Childhood Education, Federal College of Education, Eha Amufu, Enugu State, Nigeria.
Published: May 2021

The present study examined parental perception towards the childrens rights in Nigeria based on the perceived customary law. The studys main objective was to ascertain the influence of belief in customary law and gender on perception towards a childs right. A total of one hundred and sixty participants comprising males and females between the ages of 40 and 65 were randomly selected from rural communities in Benue State for the study. A self-developed instrument was used to measure the level of belief in customary laws and perception towards a childs right. Multiple linear regression was performed on the data. The result revealed a statistically significant predictive association between belief in customary laws and parental perception of the childs rights. Similarly, the result showed that gender as a factor predicts perception towards a childs right. Conclusions and recommendations are discussed. Keywords: Customary Law, Perception, Belief in Customary Law, Gender.
IMPROVISATION AS A MEANS OF ENHANCING THE TEACHING AND LEARNING OF MATHEMATICS IN SECONDARY SCHOOLS IN ENUGU STATE
Authors:   Department of Mathematics, Federal College of Education, Eha Amufu, Enugu State, Nigeria., a Eunice , Anumudu N. ,   Department of Mathematics, Federal College of Education, Eha Amufu, Enugu State, Nigeria., I. Yemi Adedapo ,   Department of Mathematics, Federal College of Education, Eha Amufu, Enugu State, Nigeria.
Published: May 2021

Mathematics is an essential part of the education system in Nigeria. However, it is perceived among learners as a tedious and challenging subject. The primary objective of the current study was to enhance the teaching and learning of mathematics using improvisation. The study also examined the role of students location on mathematics learning when the learning material is improvised. The population of the study included secondary school students in both rural and urban areas of Enugu State. A total of 68 secondary school students constituted the study samples. A quasi-experimental design was used. Two hypotheses were tested, and it was concluded that improvisation of learning material enhances students performance in mathematics. Also, the study found that students location does not affect performance in mathematics when instructional material is improvised. The findings and recommendations are discussed.
Daraltılmış Treyler Şasi Tasarımı ve Sonlu Elemanlar Metodu ile Yapısal Analizi
Authors: ÖZGÜR Tayfun , KARATAŞ Seyfi Burak
Published: May 2021

Otomotiv sektöründe taşımacılıkta treyler tipi ağır vasıtalar büyük öneme sahiptir. Ülkemizde gerek kullanım alanının geniş olması gerekse de ekonomik ve tecrübeli servis hizmetlerinin bulunması ile damperli treyler tipi taşıtlar daha çok tercih edilmektedir. Damperli treyler tipi araçların ağırlığının büyük oranını şasi oluşturmaktadır. Treyler şasisi dinamik ve statik birçok kuvvete maruz kalmaktadır. Bu sebeplerden treyler üreticileri tarafından da öncelikli çalışma konusu olarak şasi tercih edilmektedir. Bu çalışmada bir treyler şasisinin enine uzunluğu dar yapıda yeniden modellenerek yapısal analizinin eski modeli ile karşılaştırılması amaçlanmaktadır. Bu yeni dar yapıda tasarım, DIN standartlarında belirtilen aks yay merkezleri arası mesafe dikkate alınarak oluşturulmuştur. Mukavemet değerleri korunarak dar yapıda, daha hafif, yakıt ve çevre dostu yeni bir treyler tasarlamak bu çalışmanın ana hedefini oluşturmaktadır. Bu çalışmadaki analiz ve hesaplamalar göstermektedir ki; dar yapıda modellenen treylerin %7 oranında ağırlığında bir azalma meydana gelmiştir. Sonuç olarak, ağırlık azaltımının sağladığı yakıt tasarrufu sayesinde daha çevreci bir treyler tasarımı elde edilmiştir.
Soya ve Mısır Yağından Biyodizel Üretiminin Yanıt Yüzey Metodu Kullanılarak Optimizasyonu
Authors: ÖZGÜR Ceyla
Published: May 2021

Bu çalışmada, soya fasulyesi ve mısır yağı karışımından biyodizel üretim prosesi için optimum parametreleri belirlemek amacıyla yanıt yüzey metoduna dayalı merkezi kompozit tasarımı (CCD) kullanılmıştır. Biyodizel üretiminin modellenmesi için dört değişkenli yanıt yüzey metoduna dayalı merkezi kompozit tasarımı uygulanmıştır. Bu nedenle, dört önemli üretimi parametresinin üç farklı seviyesinde 30 deney gerçekleştirilmiştir. Seçilen giriş parametreler, metanol/yağ oranı, reaksiyon süresi, katalizör miktarı ve reaksiyon sıcaklığıdır. En yüksek dönüşüm değeri %94,49 ile 6,97:1 metanol/yağ oranı, 74,99 dakika reaksiyon süresinde, %1,04 katalizör miktarında, 64,99 oC reaksiyon sıcaklığında elde edilmiştir.
Farklı Çevresel Şartlarda İki Eksenli Yüklemelere Maruz Tabakalı Kompozit Malzemelerin Hasarı
Authors: DARICIK Fatih , KIRATLI Sakine
Published: May 2021

Polimer matrisli tabakalı kompozit malzemelerin bileşenlerinin dayanım yönünden çok farklı olması bu malzeme grubunun hasar analizlerini zorlaştırmaktadır. Tabakalı kompozitlerin hasar analizleri için önerilen birçok hasar ölçütü bulunmaktadır. Bu çalışmada iki yönde düzlemsel yayılı yüke ve bir yönde yayılı yük ile kayma yüküne maruz S-cam lifi/epoksi ve karbon lifi/epoksi tabakalı kompozit malzemelerin Tsai-Wu ve Puck ölçütüne göre hasarı araştırılmıştır. Birçok yükleme halinde Puck ölçütü daha güvenli hasar zarfları göstermektedir. Ancak hangi hasar ölçütünün daha güvenli olduğu tabakalı kompozit malzemelerin türüne, çevresel şartlara, takviye lif açılarına ve yüklemenin işaretine göre farklılıklar göstermektedir. Her iki malzeme türünün hem açılı hem de çapraz katlı tasarımları için tüm iki eksenli yüklemelerde malzeme dayanımını en çok düşüren etken ortam nemidir. S-cam lifi/epoksi tabakalı kompozitlerde Puck ölçütü ile oluşturulan hasar zarfları ortam sıcaklığından daha fazla etkilenirken, karbon lifi/epoksi tabakalı kompozit malzemelerde Tsai-Wu ölçütü ortam sıcaklığı değişimine karşı daha duyarlı davranış göstermiştir.
Determinantes sociales del abandono de lactancia materna exclusiva en niños a término menores de 6 meses en un Centro de Salud en San Juan de Lurigancho, 2017
Authors: Prado Cuadros Teresa , Sermeño Palacios Chabely Lizbeth , Chero Pacheco Víctor Humberto
Published: May 2021

Objetivo: Establecer los determinantes sociales del abandono de lactancia materna exclusiva en niños a término menores de 6 meses en un Centro de Salud en San Juan de Lurigancho, 2017. Materiales y Métodos: El estudio fue aplicado y de nivel descriptivo con diseño no experimental- transversal. El estudio consideró a las madres con hijos de edades entre 0 y 6 meses quienes fueron atendidos en el servicio de Crecimiento y Desarrollo, siendo una población de 100 madres de donde se obtuvo una muestra de 50 madres por medio de muestreo no probabilístico. El análisis de datos se realizó por medio del programa SPSS y los resultados fueron presentados en tablas de frecuencia. Resultados: La mayoría de madres que participaron en el estudio son jóvenes entre 20 y 35 años, el 78% presentó alguna dificultad asociada al abandono de lactancia, el 68% trabaja, el 32% tiene grado de instrucción Superior Técnico, el 70% tiene conocimientos sobre técnicas de lactancia y el 62% recibió orientación. Conclusión: La alimentación es apropiada, existen dificultades que llevan al abandono de lactancia por las madres, la mayor parte de madres trabajan y además poseen estudios superiores técnicos, las madres tienen información respecto a técnicas de lactancia y han recibido la orientación debida por parte de los profesionales en los servicios sanitarios.
Eficacia del Aloe vera en la respuesta tisular de alveolos post-exodoncia en incisivos de Cavia porcellus
Authors: Vadillo Palacios Grisel Yulliana , Bernuy Torres Luis Alexis , Borja Villanueva Cesar Andrés
Published: May 2021

Introducción: En el campo de las plantas medicinales y sus beneficios sobre la salud oral, se hallan investigaciones sobre el Aloe vera, sin embargo, estos se desarrollan principalmente en la observación sobre la inflamación y no en todo el proceso de cicatrización alveolar. Debido a ello, se realiza este estudio de corte cuasi-experimental y longitudinal. Objetivo: Determinar la respuesta tisular de alveolos post-exodoncia en incisivos mandibulares de Cavia porcellus después de la aplicación intra-alveolar de Aloe vera. Materiales y Métodos: Se seleccionaron 24 animales los cuales se dividieron en 2 grupos (experimental y grupo control). La evolución de la respuesta tisular se monitoreó en periodos de 24 horas, 7 y 21 días para cada grupo. Resultados: Se obtuvieron resultados variados en cada periodo, encontrándose una mejora en las fases de reacción de células inflamatorias y granulación, caso contrario en las fases de epitelización y osteogénesis. Conclusión: El Aloe vera presenta un efecto positivo pero estadísticamente no significativo comprobándose su utilidad para la cicatrización en este tipo de herida tan característica en el campo de la odontología.
RESILIENCIA DURANTE LA EMERGENCIA SANITARIA POR COVID-19, EN MUJERES JEFAS DE HOGAR RESIDENTES EN UNA ZONA DE CARABAYLLO
Authors: Tenorio Casaperalta Anne , Paredes Echeverria Luis , Quispe Mamani Lucy
Published: May 2021

Objetivos: El objetivo de este estudio fue identificar la resiliencia durante la emergencia sanitaria por COVID-19, en mujeres jefas de hogar residentes en una zona de Carabayllo. Materiales y métodos: Se realizó un estudio basado en el enfoque cuantitativo. Su diseño fue descriptivo y transeccional. La población estuvo conformada por 315 mujeres jefas de hogar. Se utilizó la técnica de encuesta y se midió la variable principal con el Cuestionario CD-RISC-10, que permitió evaluar la capacidad y habilidad de hacer frente a la adversidad. El instrumento presenta 10 enunciados y es unidimensional. Resultados: En relación al estado civil, predomino las participantes que son convivientes con 53,7% (n=169). En cuanto al grado de instrucción, predomino las que tienen nivel básico secundario con 47,6% (n=150). En relación a la ocupación, predomino las que están sin ocupación (52,4%), seguido de las que tienen trabajo eventual (46,3%). De acuerdo al nivel de resiliencia, predomino el nivel moderado con 49% (n=155), seguido del alto en un 27,9% (n=88) y finalmente el bajo con 22,9% (n=72). Conclusiones: De acuerdo al nivel de resiliencia, resalto el nivel moderado, seguido del nivel alto y bajo. La pandemia genera una situación de adversidad, que hace más difícil la vida a este grupo de mujeres que viven en una zona vulnerable, de ahí la importancia de conocer los niveles de resiliencia que pueden permitir elaborar estrategias que les permita afrontar mejor esta situación de crisis social y sanitaria.
COMPOSICIÓN QUÍMICA DEL ACEITE ESENCIAL DE Aloysia triphylla “CEDRÓN” COMO INSUMO PARA LA ELABORACIÓN DE UN ENJUAGUE BUCAL
Authors: Huerta Leon Jenny Rosalyn , Samaniego Joaquin Jhonnel Williams , Fuertes Ruiton César
Published: May 2021

Objetivos: Determinar la composición química del aceite esencial de Aloysia triphylla “Cedrón”, obtenido a partir de las hojas y tallos por el método de arrastre de vapor, que a su vez sirva como insumo para la elaboración de un enjuague bucal que pueda combatir la halitosis. Materiales y métodos: El material vegetal se recolectó de la ciudad de Huaraz y fue secado al medio ambiente, la extracción del aceite esencial se realizó por el método de hidrodestilación con arrastre de vapor de agua a presión y temperatura controlada, se almacenó en un frasco de vidrio ámbar en refrigeración. El rendimiento se determinó por el método gravimétrico volumétrico. La determinación de los componentes químicos se realizó por el método de Cromatografía de gases acoplada a espectrometría de masas utilizando un Cromatógrafo de gases marca Agilent Technologies 7890, detector espectrómetro de masas Agilent Technologies 5975C, Columna J&W 122- 1545.67659 DB-5ms, 325°C 60m x 250 μm x 0,25 μm. Resultados: Se obtuvo un porcentaje de rendimiento de 0,13%. Con respecto a la composición química del aceite esencial se encontraron 23 compuestos identificados por tiempos de retención y se obtuvieron 15,62% de Limoneno, 18,15% de β-citral y 25,13% de α-citral como los compuestos volátiles de mayor concentración presentes en el aceite esencial. Conclusiones: Se concluye que, según la determinación de los compuestos presentes en mayor porcentaje como Limoneno, β-citral y α-citral de propiedades antibacterianas, se puede elaborar un enjuague bucal para el tratamiento de la halitosis producida por el metabolismo de bacterias en la cavidad oral.
BIOEXENCIÓN DE DOS MEDICAMENTOS CONTENIENDO ÁCIDO ACETILSALICÍLICO 100 mg EN TABLETAS
Authors: Huerta Leon Jenny Rosalyn , Grande Ortiz Miguel , Samaniego Joaquin Jhonnel Williams , Inocente Camones Miguel Ángel
Published: May 2021

Objetivos: Determinar la bioexención de dos medicamentos multifuentes (genéricos) conteniendo Ácido acetilsalicílico 100 mg en tabletas. Materiales y métodos: Estudio descriptivo comparativo con determinación de parámetros estadísticos que reflejaron la validez, la objetividad y confiabilidad de la metodología analítica. Se utilizaron dos productos multifuente dispensados en establecimientos farmacéuticos en Lima y el producto de referencia. Los perfiles de disolución fueron cuantificados por la técnica por Espectrofotometría ultravioleta-visible Estos perfiles se evaluaron realizando un análisis de modelo independiente que se basó en la determinación del factor de similitud (f2). Se establecieron los perfiles de disolución efectuados en medios a pH fisiológicos según lo establecido por la OMS (Reporte Técnico 937). Para determinar la equivalencia terapéutica se utilizó el factor de similitud (f2), teniendo en cuenta que las dos fórmulas son equivalentes terapéuticos in vitro si los valores se encuentran entre 50 y 100. Resultados: Se obtuvieron que todos los productos analizados presentaron a pH 1,2 una disolución muy rápida, aunque, uno de los dos medicamentos que forman parte del presente estudio; medicamento multifuente N°2 presentó a pH 4,5 y pH 6,8 una disolución lenta con valores f2 a pH 4,5: (f2 = 26,44); y a pH 6,8: (f2 = 26,48). Conclusiones: Según los resultados de f2 determinados para las dos fórmulas de ácido acetilsalicílico; el producto multifuente N°2 (extranjero) no es equivalente terapéutico con el producto de referencia ya que no se logró demostrar su intercambiabilidad, la que si se pudo establecerlo fue el medicamento multifuente N°1.
CRIMINOLOGICAL CHARACTERISTICS OF CRIMES AGAINST FREEDOM, COMMITTED BY ORGANIZED CRIMINAL GROUPS IN THE NORTH CAUCASUS FEDERAL DISTRICT
Authors:   K.V. Chemerinskiy Institute of Service, Tourism and Design (branch) North Caucasus Federal University in Pyatigorsk, Chemerinskiy K.V.
Published: May 2021

The article provides a criminological characteristic of crimes against freedom committed by organized criminal groups in the North Caucasian Federal District. The relevance of the topic of the article is due to the fact that these crimes have become a common phenomenon in some regions of the Russian Federation, especially in the North Caucasus Federal District. The aim of the study is to determine the criminological indicators of crime against freedom committed by organized criminal groups. When writing the article, the methods of analysis and generalization of materials from investigative and judicial practice, polls, questionnaires of certain categories of the population were used. The article says that the most widespread crime in the North Caucasus Federal District, according to official statistics, is kidnapping. Determinants of criminality against personal freedom committed by organized criminal groups are listed. Particular attention is paid to corruption in law enforcement agencies, which contributes to the concealment of the facts of committing these crimes by organized criminal groups, the latency of crimes against personal freedom in the North Caucasus Federal District. Revealed and substantiated the need to develop a concept of economic transformations using the latest technologies, taking into account regional specifics. Some measures to prevent this category of crime are proposed. The result of the study is the formulation of conclusions that effective measures to counter organized crime against personal freedom are to improve the activities of the subjects of operational-search activities, as well as victimological socialization of the population
PROBLEMS OF VERIFICATION OF ACCOUNTING (FINANCIAL) STATEMENTS IN THE DOCUMENTATION OF CRIMINAL BANKRUPTCY
Authors:   S.A. Konovalenko Ryazan Branch of the Moscow University of the Ministry of Internal Affairs of Russia named after V. Ya. Kikot, Konovalenko S.A. , Trofimov M.N. ,   M.N. Trofimov Ryazan Branch of the Moscow University of the Ministry of Internal Affairs of Russia named after V. Ya. Kikot, Gadzhiev N.G. ,   N.G. Gadzhiev Dagestan State University, Abdusalamov R.A. ,   R.A. Abdusalamov Dagestan State University
Published: May 2021

Examination of documents when detecting crimes under Art. 196 and 197 of the Criminal Code of the Russian Federation, is always carried out in a certain sequence. At the initial stage, the specialist-auditor understands the specific tasks assigned to him, arising from the questions submitted for research, determines the sufficiency of the documentary data provided for the study and chooses the research methodology. One of the most important problematic issues facing a specialist auditor at the initial stage of the study is the problem of confirming the reliability of accounting (financial) statements. The purpose of the scientific article was to study the economic and legal main forms of interaction between the state and business, as well as to develop practical recommendations for their improvement. The purpose of the scientific article is to study the existing problems of the reliability of accounting (financial) statements and propose ways to solve them. Methodological base of the research. The theoretical and methodological basis of the research in the scientific article was the work of both Russian and foreign specialists in the field of control and auditing, the system of normative documents on the research topic, as well as materials from the scientific literature of leading legal scholars and economists. The main research methods used in writing the work were observation, comparison, induction, deduction and monographic (descriptive) methods.
IMPLEMENTATION OF THE PRINCIPLE OF DIVISION OF AUTHORITIES IN THE REPUBLIC OF DAGESTAN
Authors:   A.Kh. Ramazanov Dagestan State University, Ramazanov A.Kh. , Sapaeva G.A. ,   G.A. Sapaeva Dagestan State University
Published: May 2021

The article is devoted to the specifics of the implementation of the principle of separation of powers in the construction of public authorities of the Republic of Dagestan. The study of laws both at the federal and regional levels, which consolidate and implement the principle of separation of powers, shows that in Dagestan, the principle under consideration has characteristic features due to the color and originality of the republic. The existing gaps in federal legislation with regard to the conceptual apparatus and issues of the relationship between the legislative and executive authorities in the implementation of the principle under consideration lead to a distortion of the implementation of the principle of separation of powers at the level of subjects. These problems, of course, should be taken into account when carrying out the activities of the state authorities of the Republic of Dagestan, based on the principle of separation of powers.
CONDITIONS AND BASES FOR CIVIL LEGAL LIABILITY OF MINORS AGE FROM FOURTEEN TO EIGHTEEN
Authors:   Z.A. Alieva Dagestan State University, Alieva Z.A.
Published: May 2021

The article examines the conditions for the occurrence and grounds of civil liability of minors between the ages of fourteen and eighteen years. The article characterizes individual articles of the Civil Code of the Russian Federation concerning the civil liability of minors at the age in question. The idea is substantiated that by compensating for harm by parents (adoptive parents) or guardians of minors, if they do not prove that the harm arose through no fault of theirs, the legislator tries to respect the interests of persons who have suffered from the illegal actions of minors. The article presents the views of scientists regarding the conditions for the onset of civil liability of this category of minors. The features of the onset of property liability of minors between the ages of fourteen and eighteen are analyzed. Examples from judicial practice on the problems of compensation for harm caused by minors between the ages of fourteen and eighteen are given. The result of the study is the formulation of conclusions that the absence of direct responsibility of minors leads to their impunity in the future, and makes the institution of civil liability of minors formal.
Predictors of Health Information–Seeking Behavior: Systematic Literature Review and Network Analysis
Authors: Mirzaei Ardalan , Aslani Parisa , Luca Edward Joseph , Schneider Carl Richard
Published: May 2021

Background

People engage in health information–seeking behavior to support health outcomes, and being able to predict such behavior can inform the development of interventions to guide effective health information seeking. Obtaining a comprehensive list of the predictors of health information–seeking behavior through a systematic search of the literature and exploring the interrelationship of these predictors are critical first steps in this process.

Objective

This study aims to identify significant predictors of health information–seeking behavior in the primary literature, develop a common taxonomy for these predictors, and identify the evolution of the concerned research field.

Methods

A systematic search of PsycINFO, Scopus, and PubMed was conducted for all years up to and including December 10, 2019. Quantitative studies identifying significant predictors of health information–seeking behavior were included. Information seeking was broadly defined and not restricted to any source of health information. Data extraction of significant predictors was performed by 2 authors, and network analysis was conducted to observe the relationships between predictors with time.

Results

A total of 9549 articles were retrieved, and after the screening, 344 studies were retained for analysis. A total of 1595 significant predictors were identified. These predictors were categorized into 67 predictor categories, with the most central predictors being age, education, gender, health condition, and financial income. With time, the interrelationship of predictors in the network became denser, with the growth of new predictor grouping reaching saturation (1 new predictor identified) in the past 7 years, despite increasing publication rates.

Conclusions

A common taxonomy was developed to classify 67 significant predictors of health information–seeking behavior. A time-aggregated network method was developed to track the evolution of the research field, showing the maturation of new predictor terms and an increase in primary studies reporting multiple significant predictors of health information–seeking behavior. The literature has evolved with a decreased characterization of novel predictors of health information–seeking behavior. In contrast, we identified a parallel increase in the complexity of predicting health information–seeking behavior, with an increase in the literature describing multiple significant predictors.