Risk Factors for Early Рlacental Abruption: Multicenter Retrospective Cohort Study
Authors:   K.A. Gutkin Republican Perinatal Center, Petrozavodsk, Rudakova I.S. , Shifman E.M. ,   Moscow Regional Research and Clinical Institute,   N.I. Pirogov Russian National Research Medical University, Tikhova G.P. ,   Petrozavodsk State University, Andriyakhova M.A. ,   Altai State Clinical Perinatal Centre, Artymuk N.V. ,   Kemerovo State Medical University, Bagiyants V.A. ,   Sverdlovsk Regional Children Clinical Hospital, Barakaeva F.R. ,   D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Barinov S.V. ,   Omsk State Medical University, Barkovskaya N.A. , Belinina A.A. ,   Altai State Clinical Perinatal Centre, Belokrinitskaya T.E. ,   Chita State Medical Academy, Bikkuzhin R.V. ,   Petrozavodsk State University, Bulavintseva A.V. ,   Simferopol Clinical Hospital, Bukharova E.A. ,   Omsk State Medical University, Bukhtin A.A. ,   Volgograd Regional Clinical Perinatal Center No. 1, Verveiko I.G. ,   Professor G.S. Postol Perinatal Center, Khabarovsk, Gorokhovskii V.S. ,   Far Eastern State Medical University, Khabarovsk, Gurbanov D.E. ,   Saratov Medical University named after. V.I. Razumovsky, Degtyarev E.N. ,   National Medical Research Center for Obsterics, Gynecology and Perinatology named after Academician V.I. Kulakov, Eliseeva K.G. ,   Saratov Medical University named after. V.I. Razumovsky, Ivshin А.А. ,   Petrozavodsk State University, Iozefson S.A. ,   Chita State Medical Academy, Kapustin R.V. ,   D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Katkova N.Yu. ,   Privolzhsky Research Medical University, Nizhny Novgorod, Kolmakova K.A. ,   Chita State Medical Academy, Koch P.V. ,   Krasnoyarsk Regional Clinical Center for Maternal and Child Health, Kuverin A.A. ,   Perinatal Center of the Saratov City Clinical Hospital No. 8, Kuklina L.V. ,   Omsk State Medical University, Kulikov A.V. ,   Ural State Medical University, Marochko T.Yu. ,   Kemerovo State Medical University, D.V. Marshalov ,   Saratov Medical University named after. V.I. Razumovsky, Milyaeva N.M. ,   Ural State Medical University, Golovachuk A.A. ,   Medical Institute named after S.I. Georgievsky of the V.I. Vernadsky Crimean Federal University, Nadezhina E.S. ,   Perinatal Center of the Omsk Regional Clinical Hospital, Novikova S.V. ,   Moscow Regional Research Institute of Obstetrics and Gynecology, Ovechkin S.V. ,   Novosibirsk City Clinical Perinatal Center, Petrov A.V. ,   Maikop City Clinical Hospital,   Adyghe Republican Clinical Perinatal Center, Pozdnyakov I.M. ,   Novosibirsk City Clinical Perinatal Center, Prodanchuk E.G. ,   Omsk State Medical University, Pylaeva N.Yu. ,   Medical Institute named after S.I. Georgievsky of the V.I. Vernadsky Crimean Federal University, Ryazanova O.V. ,   D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Savelyeva I.V. ,   Omsk State Medical University, Sleta А.А. ,   Volgograd Regional Clinical Perinatal Center No. 1, Snezhko V.D. ,   National Medical Research Center of Surgery named after A. Vishnevsky, Tupikin M.G. ,   Krasnoyarsk Regional Clinical Center for Maternal and Child Health, Upryamova E.Yu. ,   D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Cherny A.I. ,   Saratov Medical University named after. V.I. Razumovsky Perinatal,   Center of the Saratov City Clinical Hospital No. 8, Shindyapina N.V. ,   Saratov Medical University named after. V.I. Razumovsky, Shulman O.B. ,   Maikop City Clinical Hospital,   Adyghe Republican Clinical Perinatal Center
Published: October 2024

Aim. А determination of predictors of early placental abruption (up to 34 weeks of pregnancy). Design. Multicenter retrospective cohort study. Materials and methods. The total number of cases of placental abruption — 1594, data from 22 medical centers in 16 constituent entities of the Russian Federation. The main group (n = 618) — patients with placental abruption at a gestation period of less than 34 weeks, comparison group (n = 976) — pregnant women with placental abruption at 34 weeks or more. Results. Multivariate analysis carried out using the logistic regression method revealed a statistically significant effect of smoking, pregnancy number, the presence of a scar on the uterine abnormalities of its structure on the occurrence of early placental abruption. Conclusion. Disentangling placental abruption into early and late phenotypes may provide insight into the causes of this obstetric condition and improve maternal and neonatal outcomes. Keywords: placental abruption, predictor, risk factors, phenotype.