bluuebunny/crossref_metadata_2025 huggingface dataset:
The politics of sharing: Sociotechnical imaginaries of digital platforms
Authors: Hassan Yousif
Published: April 2020

This paper looks at the role of sociotechnical imaginaries surrounding the governance of the sharing economy in two different locations: Canada and United States. Policy makers are trying to tackle the sharing economy without potentially creating negative impact on innovation. While much of the recent discourse around the sharing economy portrays it negatively, early peer-to-peer digital platforms were envisioned as new pathways toward grassroots, inclusive, fair and low-impact economies (Schor, 2016). However Jasanoff & Kim argue that the evaluation of the positive and negative aspects of technological change have always been influenced by specific tacit or explicit political imaginations of nations in terms of how to power modern social life (Jasanoff & Kim, 2013, p. 190). Using a comparative approach, this paper analyzes these imaginations as they are expressed through policy reports and recommendations. The study shows that the sharing economy appears to be seeking a set of diverse imaginaries including new economic freedom, sustainable consumption, decentralized society, demise of social hierarchies and regulatory freedom.
Improved method for compressive single-pixel imaging of a moving object
Authors: Zha Changjun
Published: April 2020

The traditional compressive imaging method for a moving object has the problem of repeated compressive sampling when the object stops moving or remains stationary. To solve this problem, this paper presents an improved method for compressive imaging in this situation. In contrast to traditional methods, the image is preprocessed before reconstruction. First, the Euclidean distance between the current measurement vector and the previous one is calculated, and then a threshold is used to determine whether the new measurement vector is valid. If the distance is below the threshold, the measurement vector is a repetition of the previous one and is discarded; otherwise, the measurement vector is valid and the measurement value is retained and used for image reconstruction. Theoretical analysis and simulation results show that the proposed method can eliminate the repeated sampling problem caused by a pause in the movement of an object, enabling effective reconstruction of the moving object image.
Top expenditure distribution in Arab countries and the inequality puzzle
Authors: Hlásny Vladimír
Published: April 2020

This study was motivated by reports of a mismatch between inequality experienced on the streets across the Arab region, and that estimated in household expenditure surveys. The study uses eleven surveys from Egypt, Jordan, Palestine, Sudan and Tunisia to investigate whether the dispersion of top expenditures and measurement errors in them bias the measurement of inequality. The expenditure distributions are corrected by replacing potentially mismeasured values with those drawn from parametric distributions. Across all surveys, expenditure inequality is found to be at or below that found in emerging countries worldwide. The Gini is consistently 0.30–0.32 in Egypt, 0.35–0.37 in Jordan, and 0.38–0.43 in Palestine, Sudan and Tunisia. Several surveys include outliers raising inequality estimates. The Egyptian, Palestinian, and Tunisian surveys exhibit smoother top tails of expenditures, approximable by parametric distributions. Across years leading up to the Arab Spring, the estimates in these countries show falling inequality, suggesting that data problems are not behind the Arab inequality puzzle.
Model representations of heat shock in terms of dynamic thermal elasticity
Authors: Kartashov E. M.
Published: April 2020

This article is devoted to mathematical models of thermal shock in terms of dynamic thermoelasticity and their application to the specific conditions of intensive heating and cooling of solids. A scheme is proposed for deriving the compatibility equation in voltages for dynamic problems, which generalizes the well-known Beltrami-Mitchell relation for quasistatic cases. The proposed relation can be used to consider numerous special cases in the theory of thermal shock in Cartesian coordinates for both bounded canonical bodies and partially bounded ones. As a detailed study, the latter case was considered under conditions of abrupt temperature heating and cooling, thermal heating and cooling, and medium heating and cooling. Numerical experiments were carried out, and the wave nature of the propagation of thermoelastic waves was described. The effect of relaxation of the solid boundary on sudden heating and sudden cooling, which has been little studied in thermomechanics, is described. It is established that this effect influences maximum of internal temperature stresses, which depend on the parameters characterizing the elastic and thermal properties of materials, as well as the heating time and cooling time. A “compatibility equation” in displacements was proposed to study the problem of thermal shock in cylindrical and spherical coordinate systems in bodies with a radial heat flow and central symmetry. The formulation of a generalized problem in the theory of thermal shock is formulated, which is of practical and theoretical interests for many areas of science and technology.
ТРЕНІНГОВИЙ ПІДХІД У РОЗВИТКУ КРЕАТИВНОГО МИСЛЕННЯ КРИМІНАЛЬНИХ АНАЛІТИКІВ ОПЕРАТИВНО-РОЗШУКОВИХ ПІДРОЗДІЛІВ
Authors: Дерев’янко Тетяна
Published: April 2020

Стаття присвячена аналізу теоретичних основ та методології тренінгу розвитку креативного мислення кримінальних аналітиків оперативно-розшукових підрозділів. Викладені матеріали обґрунтовують необхідність розвитку та вдосконалення креативності як складової професійного становлення цієї категорії оперативних працівників. Розглянутий тренінговий підхід у підготовці кримінальних аналітиків дозволяє розвинути уявлення щодо розробки психотренінгової програми розвитку креативного мислення з акцентом на групову взаємодію й особистісне зростання, усвідомлення та подолання бар’єрів вияву креативності, усвідомлення характеристик креативної середовища, формування навичок та вмінь управління креативним процесом, а також на розвиток швидкості, гнучкості й оригінальності креативного мислення.
РЕЗУЛЬТАТИ КОМПАРАТИВНОГО АНАЛІЗУ ПОГЛЯДІВ ВІТЧИЗНЯНИХ І ЗАРУБІЖНИХ ВЧЕНИХ ЩОДО ПРОБЛЕМАТИКИ ПРОФЕСІЙНОЇ ПІДГОТОВКИ
Authors: Федик Андрій
Published: April 2020

У статті представлені результати компаративного аналізу поглядів вітчизняних і закордонних науковців щодо проблеми професійного розвитку фахівців. Визначено, що професійна підготовка фахівців розглядається у різних напрямках і має спільні недоліки у професійній підготовці поява яких зумовлена низкою невідповідностей: 1) нагальною потребою суспільства у професійно-компетентних фахівцях і реальним рівнем розвитку їх професійного мислення; 2) загальним, соціальним значенням проблеми підвищення ефективності професійної підготовкита  недостатньою її розробленістю у психологічній науці. Констатовано тотожність поглядів вітчизняних та зарубіжних вчених з досліджуваної проблематики, які визначають, що професійна компетентність – це здатність виконувати функціональні обов’язки відповідно до чинних вимог. Подано психологічний ракурс щодо особливостей імплементації у професійну освіту України “західного тренду” – безперервного професійного розвитку.Охарактеризовано особливості впровадження сучасних засобів навчання на основі інформаційно-комунікаційних технологій. Відзначено потребу вироблення нових освітніх технологій і методів навчання та модернізацію професійної підготовки фахівців з метою формування належного рівня їх професійної компетентності.
Pengembangan SDM Dalam Arsitektur Bisnis Sebagai Strategi Dalam Optimasi Produktivitas Kinerja SDM
Authors: Maisari Tanni , Nur Fajrillah Asti Amalia
Published: April 2020

As time goes by the needs and aspects of competence and productivity of Human Resources (HR) are increasingly diverse to form complex communication patterns. To balance and fulfill those needs and aspects, there needs to be an increase in performance, one of them is with enterprise architecture (EA). This study raises the case of one manufacturing company with a focus on the HR management function which has problems regarding the composition and competency of HR that is uneven so that HR productivity is low. One solution to this problem is by designing an EA. The solution produced in this research is expected to be able to meet the company's business requirements which will then be able to help meet the goals of the HR management function and also the company by considering aspects of HR. The design method of this research EA uses TOGAF ADM (The Open Group Architecture Framework) which is one of the frameworks for designing EA by connecting business architecture, data, applications, and technology. TOGAF ADM is flexible so it is possible to proceed with a different framework. In this research, EA design focuses on only three stages, namely the preliminary phase, architecture vision, and business architecture. Business architecture is a phase in the TOGAF ADM which acts as the main component capable of sustaining further architecture. The business architecture contains the definition of baseline architecture and targeting which will be used as guidelines for the basis for the development of integrated information systems for the HR Management Function. Business architecture is very instrumental in helping to handle the issues and risks that occur in the company, so it can facilitate the company to make the right decision.
Organizational Ethical Culture, Moral Reasoning: Pengaruhnya terhadap Ethical Decision Making dan whistleblowing intention
Authors: Khusnah Hidayatul
Published: April 2020

This study aims to investigate the factors that can encourage individuals to do whistleblowing. Factors that are predicted to affect whistleblowing intention are organizational Ethical Culture and Moral intensity and Ethical Decision Making. The sample in this study were 63 respondents. Total questionnaires distributed were 78 questionnaires, but as many as 65 questionnaires were returned, there were 2 questionnaires that were not filled out completely, so were excluded from testing. Data analysis techniques in this study used SEM-PLS. The results of this study found a positive effect of organizational ethical culture on whistleblowing intention. This shows that organizations that have a high ethical culture tend to have high whistleblowing intentions. The next finding is that moral intensity has a positive effect on ethical decission making and whistleblowing intention. This shows that individuals who have high moral intensity decisions that are made tend to be more ethical. The final finding in this research is ethical decision making which has a positive effect on whistleblowing intention. the higher the Ethical Decision Making, the higher the Whistleblowing Intention. When someone is able to make decisions ethically, it will go hand in hand with the whistleblowing intention
Analisis 7S McKinsey PT. Hasil Rotibua Abadi Untuk Perbaikan Organisasi
Authors: Nuringtyas Rydho Jalu
Published: April 2020

This study aims to identify and find solutions to delay construction work happening on the SCE project. The SCE project is a school building construction project. The background of this study is due to indications of delay with a difference of 25% between the schedule plan and the reality in the ground. The factors that cause the delay must be well identified so that a larger delay can be avoided and can provide solutions to these problems. From the results of Fishbone analysis and AHP, 11 factors were found to influence the delay in SCE project.
Improving the Properties of Self-compacted Concrete with Using Combined Silica Fume and Metakaolin
Authors: Sharbatdar Mohammad Kazem , Abbasi Mohammad , Fakharian Pouyan
Published: April 2020

The viscosity is the main property of self- compacted concrete (SCC) and using of pozzolan material such as metakaolin (MK) and Silica fume (SF) can help to achieve that goal. The effect of simultaneous substitution of MK and SF instead of cement on the rheological and mechanical properties of self-compacted concrete was experimentally investigated in this paper. Seventeen mix designs were cast with a substitution weight percentage (5, 10, 15, 20 %) in water to adhesive material ratio equal 0.32. All mixes were examined by compressive, tensile strengths and water absorption tests with an appropriate fluidity, without having signs of segregation or instability. The test results were indicated that the SCC mixes containing MK and SF had higher compressive and tensile strengths in comparison with no-pozzolan concrete. The comparison of linear multiple regression techniques (LMRT) and nonlinear multiple regression technique outputs with experimental results showed an appropriate similarity.
Fair Trade phenomenon – limits of neoclassical and chances of heterodox economics
Authors: Horodecka Anna , Śliwińska Magdalena
Published: April 2020

Contemporary research exploring the Fair Trade movement does not provide a clear answer whether the overall impact of Fair Trade is positive or negative and what are the real motives of Fair Trade consumers. In the paper we investigate whether the assumptions of selected heterodox schools (feminist, ecological and humanist) fit better to the reality of the Fair Trade movement than those of the neoclassical theory. Although ‘better fitness’ does not necessarily mean ‘better explanation’, the mismatch with reality may constitute an obstacle in identifying a crucial aspect of the researched phenomenon (i.e. Fair Trade), harming explanation of its existence and development.
Realia partycypacji interesariuszy w polskim zarządzaniu publicznym: „Gra w atom” Piotra Stankiewicza
Authors: Sroka Jacek
Published: April 2020

Tekst jest recenzją książki Piotra Stankiewicza Gra w atom zawierającej rezultaty oryginalnych badań nad stanem społecznego zarządzania technologią w Polsce na przykładzie energetyki jądrowej.
Embedded Sensor System for Five-degree-of-freedom Error Detection on Machine Tools
Authors: Huang Yubin , Fan Kuang-Chao , Sun Wei
Published: April 2020

Any linear stage of machine tool has inherent six-degree-of-freedom (6-DOF) geometric errors. Its motion control system, however, has only the position feedback. Moreover, the feedback point is not the commanded cutting point. This is the main reason why the positioning error along each axis and the volumetric error in the working space are inevitable. This paper presents a compact 5-DOF sensor system that can be embedded in each axis of motion as additional feedback sensors of the machine tool for the detection of three angular errors and two straightness errors. Using the derived volumetric error model, the feedback point can be transferred to the cutting point. The design principle of the developed 5-DOF sensor system is described. An in-depth study of systematic error compensation due to crosstalk of straightness error and angular error is analyzed. A prototype has been built into a three-axis NC milling machine. The results of a series of the comparison experiments demonstrate the feasibility of the developed sensor system.
Effect of Microstructures and Mechanical Properties of Large Deformation High Entropy Alloy CoCrCuFeNi in Semi-solid Isothermal Heat Treatment
Authors: WANG Lajie , XIONG Jiao , LIU Jun , YANG X J
Published: April 2020

The semi-solid slurries of the CoCrCuFeNi high entropy alloy (HEA) were fabricated through the recrystallization and partial melting (RAP) process by cold-rolling and partial remelting. The temperature range of the semi-solid region and the relationship between the liquid fraction and the temperature were determined by the differential scanning calorimetry (DSC) curve. The effect of isothermal temperature and holding time on the evolution of the microstructure and mechanical properties of the rolled samples was analyzed. The results show that the microstructure was significantly deformed, and the tensile strength has been increased by 107% after 63% rolling deformation of the CoCrCuFeNi high entropy alloy (HEA). The high-entropy alloy after cold rolling was maintained at 1150 and 1300 ° C for 20, 30, 60, and 120 minutes respectively, the plasticity has been improved compared with the rolled high entropy alloy. The optimal plasticity was reached 13.7% and 7.9% at 1150 ℃ and 1300℃ for 30 minutes, respectively. After semi-solid isothermal heat treatment, the grain morphology changed from dendritic of as-cast or rolled to spherulite and the grain size increased significantly with time and the holding temperature increased.
Application of Xgboost Feature Extraction in Fault Diagnosis of Rolling Bearing
Authors: WANG Xingang , WANG Chao
Published: April 2020

Due to the difficulty that excessive feature dimension in fault diagnosis of rolling bearing will lead to the decrease of classification accuracy, a fault diagnosis method based on Xgboost algorithm feature extraction is proposed. When the Xgboost algorithm classifies features, it generates an order of importance of the input features. The time domain features were extracted from the vibration signal of the rolling bearing, the time-frequency features were formed by the singular value of the modal components that were decomposed by the variational mode decomposition. Firstly, the extracted time domain and time-frequency domain features were input into the support vector machine respectively to observe the fault diagnosis accuracy. Then, Xgboost algorithm was used to rank the importance of features and got the accuracy of fault diagnosis. Finally, important features were extracted and the extracted features were input into the support vector machine to observe the fault diagnosis accuracy. The result shows that the fault diagnosis accuracy of rolling bearing is improved after important feature extraction in time domain and time-frequency domain by Xgboost.
Application of Millimeter 3D Automatic Paving System in Highway Engineering Construction
Authors: DONG Yi , WANG Jie , MAO Yijia , LI Hua
Published: April 2020

In the construction of asphalt mixture pavement, there are many paving construction procedures, high requirements for machinery and personnel, unreasonable technology and so on. In this paper, the millimeter-scale 3D automatic paving control technology of asphalt mixture pavement is studied with an engineering example. From the analysis of the test results in the later stage of construction, it can be seen that the technology has achieved the goal of high precision paving, and the successful application of the technology provides valuable reference experience for similar asphalt concrete pavement construction in the future.
Experimental Investigation on Vibration Reduction Performance of Fiber Metal Laminate Beams with MRE Core
Authors: HAN Jintong , WANG Wenyu , WANG Xintong , HU Xiaoyue , WANG Ziheng , GAO Zhijiang , LI Hui
Published: April 2020

The vibration reduction characteristics of composite beams filled with magnetorheological elastomer core are studied experimentally. The fiber metal laminates with magnetorheological elastomers core is self-designed and prepared. Internal magnetic field is applied to the beam to explore its action of damping vibration performance under the magnetic field for the first time. The composite elements test system with controllable magnetic field intensity is designed and the function of each part is introduced. Then, a set of reasonable and standard vibration test flow of this type of composite beam under different magnetic field intensity is clarified, and the practical test is conducted. It has been found that the composite beam has excellent damping performance with the first 4 damping ratios being greater than 10%. Moreover, after the magnetic field is applied, its damping results can be further improved to meet the active control purpose.
Kansei Engineering Analysis of Purple-clay Teapot Based on Online Comment Data
Authors: ZHANG Xinyu , QI Bin , YANG Yanpu , SUN Xiaoming
Published: April 2020

Product form has become an important communication medium between designers and consumers. Therefore, the collection and analysis of consumer evaluation of products can provide an important reference index for product form design. In this paper, purple-clay teapot was taken as an example and comments of Tmall consumers were collected through web crawler, and the product image vocabulary was extracted to analyze the needs of users. Using the research method of Kansei Engineering, the semantic space of the modeling and image of purple-clay teapot was established, and the relationship between the modeling elements and the image of purple-clay teapot was searched, which could provide valuable reference for the modeling design of purple-clay teapot.
Preparation of Cobalt Ferrite Nanoparticles Using Fulvic Acid as A Capping Agent and Its Effect on Catalytic Activity
Authors: LI Jinxing , Badawy Abdelrahman A. , DU Guanben , ZHOU Xiaojian , Essawy Hisham A.
Published: April 2020

Cobalt ferrite was prepared by co-precipitation from cobalt and iron soluble precursors in presence of fulvic acid at different pH values, namely, 6 and 8 and compared with the same preparation in absence of fulvic acid. The presence of fulvic acid is expected to bind metal ions through bridging before co-precipitation and mineralization. The extent of binding is determined according to the pH of the process. This influences the mineralization of the resulting cobalt ferrite and the crystallization/ordering of its lattice. In addition, the extent of residual ferric oxide is also a function of the efficiency of binding process. This route of modification for the co-precipitation process was found to be accompanied by enhanced surface area and total pore volume for most of the prepared samples. The involvement of these oxides as catalysts in the photo-catalytic degradation of phenol from wastewater was found to contribute very efficiently and the removal reached about 88% in some cases, which can be attributed to olation and oxolation process of the formed nanoparticles.
Теоретико-методологічний аналіз способів вимірювання самооцінки в дорослому віці
Authors: Менжега Катерина
Published: April 2020

Мета – оглянути провідні інструменти вимірювання самооцінки в дорослому віці та теоретичні концепції, на яких вони базуються. Методи. В статті представлені методи вивчення самооцінки у дорослому віці, що найчастіше використовуються у вітчизняній психології. Розкриваються базові теоретичні принципи кожного підходу, дається їх критичний аналіз. Результати. Пояснене співвідношення понять та критеріїв, використаних для опису самооцінки. Окреслені методологічні проблеми, що супроводжують емпіричне дослідження самооцінки та самоставлення. Констатовано, що самоставлення розглядається як прояв особистісного сенсу – відношення мети діяльності до її мотиву, представлене суб'єкту у формі емоцій. Власне «Я», презентоване людині у вигляді певних властивостей, рис, особливостей поведінки, також має особистісний сенс, що відображає, наскільки ті чи інші особливості дозволяють задовольнити її потреби. Висновки. Аналіз популярних методів діагностики самооцінки дозволив виділити основні теоретико-методологічні підходи: самооцінка як усвідомлене самоставлення, розуміння когнітивних та емоційних компонентів самосвідомості, уявлення особистості про себе; самооцінка як стійка особистісна риса, що зумовлює загальну активність та рівень домагань людини,самооцінка як динамічний стан, що виконує функцію регуляції поведінки, самооцінка як міра розходження між реальним та ідеальним «Я». Відзначено, що в рамках кожного підходу дослідники виділяють специфічні компоненти самооцінки і взаємозв'язки між ними. Різноманітність підходів впливає на різноманіття методик. Методи, засновані на вербальних самозвітах, забезпечують кількісний підхід, можливість порівняння та співставлення результатів, однак апелюють до усвідомлених аспектів самоставлення і обмежують респондента заданими рамками підібраних тверджень та варіантів відповідей. Проективні методики пов'язані з проблемою інтерпретації показників. Методи непрямих оцінок частково усувають ці недоліки.
Теоретичне обґрунтування комплексної програми соціально-психологічного тренінгу формування професійної емпатії майбутніх рятувальників
Authors: Вавринів Олена
Published: April 2020

У статті проаналізовано погляди на емпатію, зокрема, особистісний та професійний. Розглянуто роль емпатії у професіях допомагаючого типу, а саме психологів, медиків, соціальних працівників, працівників аварійно-рятувальних служб. Встановлено, що емпатія виступає як мотив-посередник у допомагаючій діяльності та проявляється у різних формах, таких як допомога, просоціальна і альтруїстична поведінка. Теоретично обґрунтовано зміст комплексної програми соціально-психологічного тренінгу формування професійної емпатії майбутніх рятувальників. Показано, що впровадження комплексної програми соціально-психологічного тренінгу сприяло формуванню професійної емпатії майбутніх рятувальників, а також розвитку інших професійно важливих якостей, зокрема, готовність до ризику, мотивація досягнення успіху, високий рівень просторових уявлень, високий рівень нервово-психічної стійкості, впевненість, використання активних дії у стресових ситуаціях, підвищений рівень готовності до екстремальної діяльності. Оскільки при розробці тренінгу було враховано особливості професійного та особистісного становлення майбутніх рятувальників, актуальні проблеми службової діяльності, у спілкуванні та міжособистісних стосунках.
Особливості стилю саморегульованої навчальної діяльності студентів
Authors: Балашов Едуард
Published: April 2020

У статті розглядаються особливості стилю саморегуляції студентів, визначені за допомогою опитувальника «Стиль саморегуляції поведінки» В. Моросанової. Метою нашого дослідження є теоретичне визначення психологічних особливостей і концептуальних характеристик, емпіричне визначення стилів саморегуляції у навчальній діяльності студентів, а також визначення кореляційних зв’язків між рівнями саморегуляції навчання студентів та її стилями за допомогою коефіцієнта кореляції Спірмена.
Згідно результатів нашого емпіричного дослідження констатуємо, що у досліджуваній групі переважає середній рівень (майже 45%), а також оперативний стиль (понад 60%) саморегуляції поведінки навчальної діяльності студентів. Легко бачити, що серед студентів переважає оперативний стиль саморегуляції діяльності (відповідно 14,0% на високому рівні, 30,2% на середньому рівні та 18,6% на низькому рівні). Наступним за мірою розповсюдження серед респондентів у нашому дослідженні є автономний стиль саморегульованої навчальної поведінки (відповідно 7% респондентів на високому рівні, 11,7 % на середньому рівні та 4,6 % на низькому рівні саморегуляції). Емпіричні дослідження виявили, що найменш характерний для респондентів є стійкий стиль саморегуляції навчальної діяльності (9,3% на високому рівні, по 2,3% на середньому та низькому рівнях).
Статистична обробка емпіричних даних показала значну пряму кореляцію між середнім рівнем саморегуляції та її оперативним стилем у студентів, пряму кореляційна залежність між високим рівнем саморегуляції навчальної діяльності та стійким стилем саморегуляції, а також обернену кореляцію між середнім рівнем саморегуляції навчання та її автономним стилем.
Представлено аналіз та графічне зображення результатів дослідження студентів. Результати дослідження відображені у вигляді графічних зображень кожної з визначених характеристик. Зроблено висновки щодо важливості формування у студентів оптимального стилю саморегуляції, що дозволить усвідомлювати свою навчальну поведінку і виконувані навчальні дії, а також управляти ними з метою підвищення ефективності цієї навчальної діяльності.
Electrocardiographic Findings in Acutely and Chronically T. cruzi-infected Mice Treated by a Phenyl-Substituted Analogue of Furamidine DB569
Authors: De Souza Elen M. , Oliveira Gabriel M. , De Nazaré C. Soeiro Maria
Published: April 2020

Aromatic diamidines have been successfully used to combat a wide range of parasites that cause important human infections. Recently we reported that a N-phenyl-substituted analogue of furamidine (DB569) exerts a micromolar trypanocidal activity against Trypanosoma cruzi in vitro. Since DB569 also reduces the cardiac parasitism and increases the survival rates of T. cruzi-infected mice, our present aim was to analyze the potential protection of DB569 in the development of altered cardiac electrical conduction system during acute and chronic T. cruzi infection. In our experimental model of acute infection (Swiss mice inoculated with Y strain of T. cruzi), the prevailing disorder observed in electrocardiogram (ECG) analyses was sinus bradycardia. This ECG alteration was reverted in acutely infected mice treated with DB569. Interestingly, the DB569 treatment reduced signifi cantly the numbers of CD8+ T cells in the cardiac infi ltration. In addition, the noticed protection of DB569 in the ECG fi ndings of acutely-infected animals was further extended to the chronic infection. Our data suggest that the reversion to and further maintenance of normal ECG profi le in the DB569-treated infected animals may be associated with the reduced cardiac CD8+ lymphocyte infi ltration and parasitism that might be ultimately contributing to their increased survival rates.
Management of Diabetes Associated with Nephrotic Syndrome: Therapeutic Potential of Dapagliflozin for Protracted Volume Retention
Authors: Imai Toshimi , Akimoto Tetsu , Ito Chiharu , Masuda Takahiro , Nagata Daisuke
Published: April 2020

A 48-year-old female was admitted to our hospital presenting with a chief complaint of progressive swelling because of diabetic nephrotic syndrome. Dapagliflozin seemed to play a role in accelerating the patient’s urinary sodium excretion as well as reducing gross fluid retention despite the fact that her nephrotic condition was resistant to furosemide. Our experience emphasizes a potential novel approach to overcoming loop diuretic resistance using this agent among some subsets of type 2 diabetic subjects complicated with severe volume accumulation. We believe that combination treatment consisting of dapagliflozin and furosemide may produce diuretic synergy via sequential nephron blockade. The accumulation of more experience with additional cases similar to ours requires continuous and careful attention.
Pengelolaan Limbah Cair Tempe Air Rebusan dan Air Rendaman Kedelai
Authors: Sari Devitasari , Rahmawati Anyta
Published: April 2020

Pengelolaan limbah cair yang tidak benar dapat menimbulkan pencemaran air yang secara langsung atau tidak langsung dapat mengganggu kesehatan makhluk hidup disekitarnya. Proses pembuatan tempe dalam setiap tahapannya rata-rata menggunakan air untuk pencucian,perendaman dan perebusan kedelai, hal ini berarti limbah cair yang dihasilkan cukup banyak. Tujuan dari penelitian ini adalah untuk menganalisa kandungan limbah cair tempe air rebusan dan air rendaman kedelai untuk bisa di manfaatkan kembali oleh masyarakat atau pengrajin tempe.

Sampel yang digunakan adalah limbah cair tempe air rebusan dan air rendaman kedelai di salah satu pengusaha tempe di Kampung Sanan Kota Malang. Sampel tersebut kemudian dilakukan uji untuk melihat kandungan BOD, COD, TSS, dan TDS. Selain itu juga diuji kandungan nutrisi pada limbah cair tempe air rebusan dan air rendaman kedelai, yaitu protein, karbohidrat, lemak,air dan abu.

Hasil penelitian menunjukan bahwa BOD, COD, TSS, dan TDS pada kedua limbah cair tempe melebihi baku mutu yang ditetapkan oleh Peraturan Gubernur Jawa Timur Nomor 72 Tahun 2013 tentang Baku Mutu Air Limbah Bagi Industri dan/atau Kegiatan Usaha Lainnya. Sedangkan untuk kandungan protein,karbohidrat, dan lemak ada tapi tidak terlalu tinggi, hal ini menunjukan bahwa limbah cair tempe tersebut dapat dimanfaatkan kembali yaitu menjadi nata de soya atau produk lainnya. Pemanfaatan kembali limbah cair tempe  dapat mengurangi pencemaran air.
Thermal data analysis for urban climate research: A case study of Olomouc, Czechia
Authors: Pour Tomáš , Voženílek Vít
Published: April 2020

Due to the recent advancements in thermal camera technology, it is easier than ever to acquire information about surface temperature in very-high or extreme spatial resolution from manned or unmanned airborne vehicles. The main objective of the paper is to investigate the possibilities of extreme resolution thermal data for urban climate research. The main dataset used for the work is thermal mosaic acquired by an aeroplane above the city of Olomouc in the morning and afternoon on 10th July 2016. The spatial resolution of the dataset fluctuates between 90 and 100 cm per pixel edge. Auxiliary data used for the analysis included open data from European programmes Urban Atlas and CORINE Land Cover. For further analysis, building height information, material type and Local Climate Zones classification were used. The results show a possible comparison in various neighbourhoods and material types while maintaining reference units – Urban Atlas/CORINE Land Cover classes or Local Climate Zones. Verticality analysis shows a significant difference between ground and rooftop levels that need to be taken into account when investigating heat for quality of life. All the analyses confirmed knowledge about the difference between natural and artificial surfaces that most artificial surfaces tend to heat up much more during daytime and fail to cool down completely during the night-time. Moreover, this research lays the foundation to future urban climate research based on extreme resolution thermal images over multiple areas or during long-lasting campaigns.
N-(2-Hydroxypropyl) Methacrylamide Based Cryogels – Synthesis and Biomimetic Modification for Stem Cell Applications
Authors: GOLUNOVA A. , JAROŠ J. , JURTÍKOVÁ V. , KOTELNIKOV I. , KOTEK J. , HLÍDKOVÁ H. , STREIT L. , HAMPL A. , RYPÁČEK F. , PROKS V.
Published: April 2020

The design of favorable mechanical properties and suitable surface modifications of hydrogels in order to stimulate specific cell response is a great challenge. N-(2-Hydroxypropyl) methacryl-amide (HPMA) was utilized to form macroporous cryogel scaffolds for stem cell applications. Furthermore, one group of scaffolds was enhanced by copolymerization of HPMA with methacryloyl-GGGRGDS-OH peptide in an effort to integrate biomimetic adhesion sites. The cryogels were characterized by stiffness and equilibrium swelling measurements as well as by scanning electron microscopy. Cell culture experiments were performed with human adipose-derived stem cells and substrates were found completely non-toxic. Moreover, RGDS-enriched cryogels supported cell attachment, spreading and proliferation, so they can be considered suitable for designed aims.
Preparation of Monodisperse Porous Silica Particles Using Poly(Glycidyl Methacrylate) Microspheres as a Template
Authors: GRAMA S. , HORÁK D.
Published: April 2020

Monodisperse macroporous poly(glycidyl methacrylate) (PGMA) microspheres were used as a template for preparing porous silica particles. The starting polymer microspheres that were 9.3 μm in size were synthesized by multistep swelling polymerization using a modified Ugelstad technique. Subsequently, silica (SiO2) was deposited on the surface and inside the PGMA microspheres to produce poly(glycidyl methacrylate)-silica hybrid particles (PGMA-SiO2). Upon calcination of the PGMA-SiO2 microspheres, porous silica particles were formed. The morphology, particle size, polydispersity and inner structure of the silica microspheres were investigated by scanning and transmission electron microscopy. Thermogravimetric analysis and dynamic adsorption of nitrogen determined the amount of silica formed and its specific surface area. Compared with the starting PGMA microspheres, the size of the porous silica particles decreased by up to 30 %. These porous silica microspheres are promising for chromatography and biomedical applications.
Recombinant Expression, In Vitro Refolding and Characterizing Disulfide Bonds of a Mouse Inhibitory C-Type Lectin-Like Receptor Nkrp1b
Authors: HERNYCHOVÁ L. , MRÁZEK H. , IVANOVA L. , KUKAČKA Z. , CHMELÍK J. , NOVÁK P.
Published: April 2020

As a part of the innate immunity, NK (Natural Killer) cells provide an early immune response to different stimuli, e.g. viral infections and tumor growths. However, their functions are more complex; they play an important role in reproduction, alloimmunity, autoimmunity and allergic diseases. NK cell activities require an intricate system of regulation that is ensured by many different receptors on a cell surface which integrate signals from interacting cells and soluble factors. One way to understand NK cell biology is through the structure of NK receptors, which can reveal ligand binding conditions. We present a modified protocol for recombinant expression in Escherichia coli and in vitro refolding of the ligand-binding domain of the inhibitory Nkrp1b (SJL/J) protein. Nkrp1b identity and folding was confirmed using mass spectrometry (accurate mass of the intact protein and evaluation of disulfide bonds) and one-dimensional nuclear magnetic resonance spectroscopy. The intention is to provide the basis for conducting structural studies of the inhibitory Nkrp1b protein, since only the activating Nkrp1a receptor structure is known.
Nanotherapeutics With Anthracyclines: Methods of Determination and Quantification of Anthracyclines in Biological Samples
Authors: KOZIOLOVA E. , JANOUSKOVA O. , CHYTIL P. , STUDENOVSKY M. , KOSTKA L. , ETRYCH T.
Published: April 2020

Anthracyclines, e.g. doxorubicin, pirarubicin, are widely used as cytostatic agents in the polymer nanotherapeutics designed for the highly effective antitumor therapy with reduced side effects. However, their precise dosage scheme needs to be optimized, which requires an accurate method for their quantification on the cellular level in vitro during nanocarrier development and in body fluids and tissues during testing in vivo. Various methods detecting the anthracycline content in biological samples have already been designed. Most of them are highly demanding and they differ in exactness and reproducibility. The cellular uptake and localization is predominantly observed and determined by microscopy techniques, the anthracycline content is usually quantified by chromatographic analysis using fluorescence detection. We reviewed and compared published methods concerning the detection of anthracycline nanocarriers.
Effect of Different Dietary Inclusion Levels of Sunflower Meal and Multi-Enzyme Supplementation on Performance, Meat Yield, Ileum Histomorphology, and Pancreatic Enzyme Activities in Growing Quails
Authors: Tüzün Ahmet Engin , Olgun Osman , Yıldız Alp Önder , Şentürk Esra Tuğçe
Published: April 2020

This study aimed to investigate the effect of dietary sunflower meal (SFM) and multi-enzyme levels on performance, carcass traits, intestinal histomorphology and pancreatic enzyme production in quails. Three hundred and twenty, 1-day-old quail chicks were divided into 8 groups with 4 replicates consisting of 10 birds each in the group. The experiment was randomized design consisting of a 4 × 2 factorial arrangement, with four levels of SFM (0%, 10%, 15%, or 20%) and two levels of multi-enzyme (0.0 or 1.0 g/kg) inclusion in the diet. The body weight, body weight gain, and feed conversion ratio were negatively influenced by the 15% and 20% SFM (p < 0.01) but were not affected by the 10% SFM for 6 week age. The relative gizzard (p < 0.05) weights significantly increased with 20% SFM, but the relative breast weight decreased (p < 0.01). The relative liver weight increased by the addition of enzymes in the diet (p < 0.05). The villus width (p < 0.01) and villus surface area (p < 0.05) of ileum increased linearly with SFM, whereas the villus height (p < 0.01), villus height: crypt depth (p < 0.01) and tunica muscularis thickness (p < 0.01) decreased linearly with SFM. Consequently, it is possible to say that the birds with the least absorptive same weight are the most efficient. The addition of multi-enzyme increased villus height and crypt depth but decreased tunica muscularis thickness of ileum (p < 0.01). Chymotrypsin activity in the pancreas decreased linearly with SFM (p < 0.01). Amylase activity in the pancreas decreased significantly with the addition of the multi-enzyme (p < 0.05). As a result of the study, SFM can be used at a 10% level in growing quail diets with beneficial effects on the absorption surface area. The effects of enzyme supplementation on parameters measured were less pronounced than the SFM inclusion level that higher villus height and lower tunica muscularis thickness were determined in multi-enzyme-fed birds compared to those untreated counterparts.
Identification of Water Hammering for Centrifugal Pump Drive Systems
Authors: Dutta Nabanita , Palanisamy Kaliannan , Subramaniam Umashankar , Padmanaban Sanjeevikumar , Holm-Nielsen Jens Bo , Blaabjerg Frede , Almakhles Dhafer Jaber
Published: April 2020

Water hammering is a significant problem in pumping systems. It damages the pipelines of the pump drastically and needs to identify with an intelligent method. Various conventional methods such as the method of characteristics and wave attenuation methods are available to identify water hammering problems, and the predictive control method is one of the finest and time-saving methods that can identify the anomalies in the system at an early stage such that the device can be saved from total damage and reduce energy loss. In this research, a machine learning (ML) algorithm has used for a predictive control method for the identification of water hammering problems in a pumping system with the help of simulations and experimental-based works. A linear regression algorithm has been used in this work to predict water hammering problems. The efficiency of the algorithm is almost 90% compared to other ML algorithms. Through a Vib Sensor app-based device at different pressures and flow rates, the velocity of the pumping system, a fluctuation between healthy and faulty conditions, and acceleration value at different times have been collected for experimental analysis. A fault created to analyze a water hammering problem in a pumping system by the sudden closing and opening of the valve. When the valve suddenly closed, the kinetic energy in the system changed to elastic resilience, which created a series of positive and negative wave vibrations in the pipe. The present work concentrates on the water hammering problem of centrifugal pumping AC drive systems. The problem is mainly a pressure surge that occurs in the fluid, due to sudden or forced stops of valves or changes in the direction and momentum of the fluid. Various experimental results based on ML tool and fast Fourier transformation (FFT) analysis are obtained with a Vib Sensor testbed set-up to prove that linear regression analysis is the less time-consuming algorithm for fault detection, irrespective of data size.
Variational Assimilation of the Impervious Surfaces Temperature
Authors: Meng Chunlei
Published: April 2020

Impervious surface temperature is a key parameter in impervious surface energy balance. Urban canopy models are now widely used to simulate impervious surface temperatures, but the physical assimilation method for the urban canopy model is still under development and the use of high temporal resolution observation data are limited. In this paper, a physical assimilation method was used to improve the simulation of the impervious surface temperature for the first time. A variational assimilation method was developed and coupled with the integrated urban land model, using the impervious surface energy balance equation as the adjoint physical constraint. The results showed that when the observed impervious surface temperature data of every timestep were assimilated into the integrated urban land model, the bias of the impervious surface temperature was reduced about 86 %. For the operational run, the observed data were assimilated twice per day, and the bias of the impervious surface temperature was reduced by about 78%.
Multigene Panel Germline Testing of 1333 Czech Patients with Ovarian Cancer
Authors: Lhotova Klara , Stolarova Lenka , Zemankova Petra , Vocka Michal , Janatova Marketa , Borecka Marianna , Cerna Marta , Jelinkova Sandra , Kral Jan , Volkova Zuzana , Urbanova Marketa , Kleiblova Petra , Machackova Eva , Foretova Lenka , Hazova Jana , Vasickova Petra , Lhota Filip , Koudova Monika , Cerna Leona , Tavandzis Spiros , Indrakova Jana , Hruskova Lucie , Kosarova Marcela , Vrtel Radek , Stranecky Viktor , Kmoch Stanislav , Zikan Michal , Macurek Libor , Kleibl Zdenek , Soukupova Jana
Published: April 2020

Ovarian cancer (OC) is the deadliest gynecologic malignancy with a substantial proportion of hereditary cases and a frequent association with breast cancer (BC). Genetic testing facilitates treatment and preventive strategies reducing OC mortality in mutation carriers. However, the prevalence of germline mutations varies among populations and many rarely mutated OC predisposition genes remain to be identified. We aimed to analyze 219 genes in 1333 Czech OC patients and 2278 population-matched controls using next-generation sequencing. We revealed germline mutations in 18 OC/BC predisposition genes in 32.0% of patients and in 2.5% of controls. Mutations in BRCA1/BRCA2, RAD51C/RAD51D, BARD1, and mismatch repair genes conferred high OC risk (OR > 5). Mutations in BRIP1 and NBN were associated with moderate risk (both OR = 3.5). BRCA1/2 mutations dominated in almost all clinicopathological subgroups including sporadic borderline tumors of ovary (BTO). Analysis of remaining 201 genes revealed somatic mosaics in PPM1D and germline mutations in SHPRH and NAT1 associating with a high/moderate OC risk significantly; however, further studies are warranted to delineate their contribution to OC development in other populations. Our findings demonstrate the high proportion of patients with hereditary OC in Slavic population justifying genetic testing in all patients with OC, including BTO.
MR Thermometry Data Correlate with Pathological Response for Soft Tissue Sarcoma of the Lower Extremity in a Single Center Analysis of Prospectively Registered Patients
Authors: Unsoeld Michaela , Lamprecht Ulf , Traub Frank , Hermes Barbara , Scharpf Marcus , Potkrajcic Vlatko , Zips Daniel , Paulsen Frank , Eckert Franziska
Published: April 2020

Background: There is a strong biologic rationale for using locoregional hyperthermia in soft tissue sarcoma and a randomized trial reported significant improvements with hyperthermia. The aim of this study was to describe the opportunities of magnetic resonance (MR)-based thermometry in a cohort of soft tissue sarcoma patients undergoing combined radiotherapy and locoregional hyperthermia. Patients and Methods: For eleven evaluable patients, tumor volume (VTu) and a separate volume for temperature analysis with reliable temperature distribution (Vtherm) were contoured for every hyperthermia treatment (103 therapies). Temperature data were recorded for all tumors and were correlated with clinical features and pathologic response data. Results: Of 48 patients with high-risk soft tissue sarcomas treated with radio(chemo)therapy and locoregional hyperthermia, MR thermometry was possible in 11 (23%) patients. For all patients, the temperature superseded by 90% of VTu (T90(VTu)) and T90 (Vtherm) were in the range of 37–43 °C and 40–45 °C, respectively. Larger tumors tended to reach higher temperatures. For tumors showing a pathologic response in the resection specimen after preoperative treatment, temperature (T90 (Vtherm)) was significantly higher than in tumors without pathologic response. Conclusion: Lower extremity sarcomas undergoing preoperative treatment with locoregional hyperthermia are especially suitable for MR thermometry. MR thermometry is a promising non-invasive way for temperature measurement during locoregional hyperthermia, showing a positive dose-response relationship.