bluuebunny/crossref_metadata_2025 huggingface dataset:
Lysosomal Acid Lipase Deficiency Unmasked in Two Children With Nonalcoholic Fatty Liver Disease
Authors: Himes Ryan W. , Barlow Sarah E. , Bove Kevin , Quintanilla Norma M. , Sheridan Rachel , Kohli Rohit
Published: September 2016

Lysosomal acid lipase deficiency (LAL-D) is a classic lysosomal storage disorder characterized by accumulation of cholesteryl ester and triglyceride. Although it is associated with progressive liver injury, fibrosis, and end-stage liver disease in children and adolescents, LAL-D frequently presents with nonspecific signs that overlap substantially with other, more common, chronic conditions like nonalcoholic fatty liver disease (NAFLD), metabolic syndrome, and certain inherited dyslipidemias. We present 2 children with NAFLD who achieved clinically significant weight reduction through healthy eating and exercise, but who failed to have the anticipated improvements in aminotransferases and γ-glutamyl transferase. Liver biopsies performed for these “treatment failures” demonstrated significant microvesicular steatosis, prompting consideration of coexisting metabolic diseases. In both patients, lysosomal acid lipase activity was low and LIPA gene testing confirmed LAL-D. We propose that LAL-D should be considered in the differential diagnosis when liver indices in patients with NAFLD fail to improve in the face of appropriate body weight reduction.
Majdal Yaba The History and Material Culture of a Fortified Village in Late Ottoman- and British Mandate-Palestine
Authors: Tsuk Tsvika , Bordowicz Iosi , Taxel Itamar
Published: September 2016

Majdal Yaba, located at the western fringes of the Samaria Hills, was a village founded in the 13th century around the former Crusader castle of Mirabel, which in its turn was built at the site of ancient Migdal Aphek. The importance of the place was raised again in the 17th century, when the village was taken over by the Rayyan family, who emigrated from Transjordan. The latter established there their own estate center in the form of a monumental, two-storey manor house built atop and around the remains of the medieval castle. This magnificent structure, though, is dated to not before the 18th century, and it had undergone several additions and renovations in the course of the 19th to early 20th centuries. In 2006, 2009 and 2010 several units of the Ottoman-Mandatory manor house, including parts of the Crusader castle, were excavated following the site’s announcement as a national park. The excavations revealed much evidence about the architecture of the manor house, which includes some urban-oriented characteristics such as built-in toilet chambers that can be considered rather unique in a rural setting. In addition, the synthesis of the ceramics and other artifacts retrieved in the excavations sheds important light on the material culture of the residents of this affluent rural complex, against the broader regional cultural and socio-political context. Specifically, some of these finds testify for the extensive process of “modernization” and globalization which started its first steps in Palestine during the 19th century, while combining pan-Ottoman and Western/European trends. This process brought about a gradual but irreversible change in many aspects of local lifestyle during early modern times.
Could Attendance at Medical School be improved? A Prospective Study of Medical Education at The University of Liverpool: Study of Attendance at a UK Medical School
Authors: Nevins Edward J. , Moori Parisa L. , Alexander Leanne , Richards Bethany , Bleasdale Victoria , Sharma Ajay K.
Published: September 2016

This article was migrated. The article was marked as recommended. Phenomenon: Attendance at UK medical school teaching sessions is on the decline. This research aimed to explore the reasons for this reduction. Approach: Attendance was assessed, by way of head counts, at 3rd year students' lectures, tutorials and problem based learning (PBL) sessions at the University of Liverpool. Reasons for absence were explored using a questionnaire sent via email to the year group. Findings: Compulsory lectures attained greater attendance than non-compulsory lectures. Access to PowerPoint presentations prior to lectures correlated with a decline in attendance as did long timetable gaps. Lectures held on-campus were poorly attended compared to those held at hospital sites where students undertook clinical placements. Unsupervised PBL sessions, with sign in sheets, achieved excellent attendance however, turnout was poor when monitoring wasn't present. Similar trends were observed for lecture attendance, indicating that students may be motivated to attend by fear of reprimand. 75 students responded to an online questionnaire exploring reasons for attendance and their responses largely agreed with our findings, however one discrepancy was highlighted. Students reported that access to lecture slides before teaching sessions would not affect attendance, although our evidence showed that when slides were available attendance declined. Insights: Attendance could be improved if teaching coincided with hospital placements. Sign-in sheets, fewer gaps between sessions and multiple lectures on one day would see a marked increase in attendees. In future, medical schools should consider these factors to enhance student motivation to attend teaching sessions.
Mitogen-Activated Protein Kinase 14 Promotes AKI
Authors: Ortiz Alberto , Husi Holger , Gonzalez-Lafuente Laura , Valiño-Rivas Lara , Fresno Manuel , Sanz Ana Belen , Mullen William , Albalat Amaya , Mezzano Sergio , Vlahou Tonia , Mischak Harald , Sanchez-Niño Maria Dolores
Published: September 2016

An improved understanding of pathogenic pathways in AKI may identify novel therapeutic approaches. Previously, we conducted unbiased liquid chromatography-tandem mass spectrometry–based protein expression profiling of the renal proteome in mice with acute folate nephropathy. Here, analysis of the dataset identified enrichment of pathways involving NFκB in the kidney cortex, and a targeted data mining approach identified components of the noncanonical NFκB pathway, including the upstream kinase mitogen-activated protein kinase kinase kinase 14 (MAP3K14), the NFκB DNA binding heterodimer RelB/NFκB2, and proteins involved in NFκB2 p100 ubiquitination and proteasomal processing to p52, as upregulated. Immunohistochemistry localized MAP3K14 expression to tubular cells in acute folate nephropathy and human AKI. In vivo, kidney expression levels of NFκB2 p100 and p52 increased rapidly after folic acid injection, as did DNA binding of RelB and NFκB2, detected in nuclei isolated from the kidneys. Compared with wild-type mice, MAP3K14 activity–deficient aly/aly (MAP3K14aly/aly) mice had less kidney dysfunction, inflammation, and apoptosis in acute folate nephropathy and less kidney dysfunction and a lower mortality rate in cisplatin-induced AKI. The exchange of bone marrow between wild-type and MAP3K14aly/aly mice did not affect the survival rate of either group after folic acid injection. In cultured tubular cells, MAP3K14 small interfering RNA targeting decreased inflammation and cell death. Additionally, cell culture and in vivo studies identified the chemokines MCP-1, RANTES, and CXCL10 as MAP3K14 targets in tubular cells. In conclusion, MAP3K14 promotes kidney injury through promotion of inflammation and cell death and is a promising novel therapeutic target.
Dapagliflozin Binds Specifically to Sodium-Glucose Cotransporter 2 in the Proximal Renal Tubule
Authors: Ghezzi Chiara , Yu Amy S. , Hirayama Bruce A. , Kepe Vladimir , Liu Jie , Scafoglio Claudio , Powell David R. , Huang Sung-Cheng , Satyamurthy Nagichettiar , Barrio Jorge R. , Wright Ernest M.
Published: September 2016

Kidneys contribute to glucose homeostasis by reabsorbing filtered glucose in the proximal tubules via sodium-glucose cotransporters (SGLTs). Reabsorption is primarily handled by SGLT2, and SGLT2-specific inhibitors, including dapagliflozin, canagliflozin, and empagliflozin, increase glucose excretion and lower blood glucose levels. To resolve unanswered questions about these inhibitors, we developed a novel approach to map the distribution of functional SGLT2 proteins in rodents using positron emission tomography with 4-[18F]fluoro-dapagliflozin (F-Dapa). We detected prominent binding of intravenously injected F-Dapa in the kidney cortexes of rats and wild-type and Sglt1-knockout mice but not Sglt2-knockout mice, and injection of SGLT2 inhibitors prevented this binding. Furthermore, imaging revealed only low levels of F-Dapa in the urinary bladder, even after displacement of kidney binding with dapagliflozin. Microscopic ex vitro autoradiography of kidney showed F-Dapa binding to the apical surface of early proximal tubules. Notably, in vivo imaging did not show measureable specific binding of F-Dapa in heart, muscle, salivary glands, liver, or brain. We propose that F-Dapa is freely filtered by the kidney, binds to SGLT2 in the apical membranes of the early proximal tubule, and is subsequently reabsorbed into blood. The high density of functional SGLT2 transporters detected in the apical membrane of the proximal tubule but not detected in other organs likely accounts for the high kidney specificity of SGLT2 inhibitors. Overall, these data are consistent with data from clinical studies on SGLT2 inhibitors and provide a rationale for the mode of action of these drugs.
Vascular Function and Uric Acid-Lowering in Stage 3 CKD
Authors: Jalal Diana I. , Decker Emily , Perrenoud Loni , Nowak Kristen L. , Bispham Nina , Mehta Tapan , Smits Gerard , You Zhiying , Seals Douglas , Chonchol Michel , Johnson Richard J.
Published: September 2016

Hyperuricemia may contribute to endothelial dysfunction in CKD. We evaluated whether lowering serum uric acid levels with allopurinol improves endothelial dysfunction in 80 participants ≥18 years of age with stage 3 CKD and asymptomatic hyperuricemia (≥7 mg/dl in men and ≥6 mg/dl in women) randomized in a double-blinded manner to receive placebo or allopurinol for 12 weeks. Randomization was stratified according to presence or absence of diabetes mellitus. We measured vascular endothelial function by brachial artery flow-mediated dilation. No significant differences existed between groups at baseline; 61% of the participants had diabetes mellitus in both groups. The placebo and the allopurinol groups had baseline serum uric acid levels (SDs) of 8.7 (1.6) mg/dl and 8.3 (1.4) mg/dl, respectively, and baseline flow-mediated dilation values (SDs) of 6.0% (5.0%) and 4.8% (5.0%), respectively. Compared with placebo, allopurinol lowered serum uric acid significantly but did not improve endothelial function. In participants without diabetes mellitus, allopurinol associated with a trend toward improved flow-mediated dilation (+1.4% [3.9%] versus −0.7% [4.1%] with placebo), but this was not statistically significant (P=0.26). Furthermore, we did not detect significant differences between groups in BP or serum levels of markers of inflammation and oxidative stress. In conclusion, allopurinol effectively and safely lowered serum uric acid levels in adults with stage 3 CKD and asymptomatic hyperuricemia but did not improve endothelial function in this sample of patients.
A clinical case of hemangioma of the face and tongue concurrent with severe obstructive sleep apnea syndrome complicated by cardiac arrhythmias and conduction disturbances
Authors: Konovalova K I , Elfimova E M , Butorova E A , Aksenova A V , Galitsin P V , Bulkina O S , Litvin A Yu , Chazova I E
Published: September 2016

The paper describes a clinical case of a female patient with severe obstructive sleep apnea syndrome in the presence of congenital hemangioma of the face, soft palate, and tongue concurrent with paroxysmal atrial fibrillation and atrial flutter, paroxysmal supraventricular tachycardia, and sinoatrial block (maximally up to 3.9 sec). Continuous positive airway pressure therapy could reduce the number of paroxysms of atrial fibrillation and atrial flutter, supraventricular tachycardia and eliminate sinoatrial block.
Multiple primary colorectal cancer: Clinical aspects
Authors: Soldatkina N V , Kit O I , Gevorkyan Yu A , Milakin A G
Published: September 2016

Aim. To define some clinical characteristics of synchronous and metachronous colorectal cancer (CRC). Materials and methods. The investigation was concerned with the data of 150 patients with T1—4N0—2M0—1 multiple primary CRC. The clinical, biological, and morphological characteristics of synchronous and metachronous tumors were analyzed. Results. Multiple primary tumors were 6.01% of all the cases of CRC. There was a preponderance of synchronous CRC (63.75%) with the tumor localized in the sigmoid colon and rectum. In women, synchronous colorectal tumors were more often concurrent with breast tumors; metachronous ones were detected after treatment for genital tumors. In men, synchronous colorectal tumors were more frequently concurrent with kidney cancer; metachronous ones were identified after treatment for gastric cancer. Conclusion. The found characteristics of multiple primary colorectal tumors may be taken in account in programs for both primary diagnosis and follow-up after treatment for malignant tumors, which will be able to improve the early detection of cancer patients and their treatment results.
Efectos de la terapia de Tracto Vocal Semi-Ocluido sobre los parámetros acústicos de la voz en docentes-Effects of the semi-occluded vocal tract therapy on acoustic parameters of the voice teachers
Authors: Vásquez Burgos Karina , Retamal Sandoval María Pilar , Zapata Urrutia Yessenia
Published: September 2016

El objetivo de esta investigación es analizar el efecto de la terapia de Tracto Vocal semi-ocluido, sobre los parámetros acústicos de la voz en docentes de educación básica de la comuna de Chillán. La presente investigación se sitúa en la población de docentes, principal grupo de profesionales que requieren usar su voz por períodos prolongados; por lo que están más expuestos a padecer desórdenes vocales. Esta investigación propone la terapia de Tracto Vocal semi-ocluido, ya que según autores como Guzmán, Titze, Belhau entre otros, ofrece resultados inmediatos manteniendo los parámetros acústicos tono e intensidad, permitiendo que se mantenga la calidad de la voz, evitando así padecer disfonías. Es entonces, la fonoaudiología la encargada de aplicar ejercicios de calentamiento y enfriamiento vocal, con el fin de evitar efectos negativos en los parámetros acústicos tono e intensidad. Metodológicamente, la investigación se orienta al paradigma cuantitativo, de tipo descriptiva y comparativa. En relación al diseño es de tipo cuasiexperimental y longitudinal. Para este efecto se midieron los parámetros acústicos de la voz utilizando el programa de análisis acústico de la voz Praat, en un grupo experimental y control. Respecto a los resultados obtenidos se evidenciaron efectos positivos sobre los parámetros acústicos de la voz, probando así la efectividad de la terapia de tracto vocal semi-ocluido.
Razones que inciden en la elección de la universidad en estudiantes del nivel secundario de la Región San Martín-Reasons that influence the choice of an University in secondary students of the Region San Martin
Authors: Tarrillo José
Published: September 2016

El objetivo del presente estudio fue identificar las razones que inciden en la elección de la universidad en estudiantes del nivel secundario de la Región San Martín. La muestra de estudio estuvo compuesta por 1528 escolares del nivel secundario, ambos sexos entre edades de 14 y 19 años. Se construyó un cuestionario que mide las razones para elegir una universidad. Se tomaron en cuenta las siguientes razones: Nivel académico, Precios de las Carreras, Ubicación física del Campus, Ambiente Estudiantil y Convenios Laborales. Las propiedades psicométricas evidencian que es válido y confiable. Entre los principales hallazgos se encontró que el 72.2% de escolares de secundaria, elegiría una universidad por el nivel académico, el 11.2% por los convenios laborales y un 7.7% por los precios de las carreras.
Iconofilia y escatología-Iconophilia and eschatology
Authors: Pereyra Mario
Published: September 2016

Partiendo de la promulgación de la ley de Dios en el Sinaí, con la prohibición de no “hacer imágenes”, se reseña históricamente las etapas principales de cómo las imágenes fueron adquiriendo mayor protagonismo hasta los tiempos hipermodernos, dominado por las “pantallas” (TV, GPS, PC, celulares, etc.) y una cultura hipervisual globalizada, que podría llamarse iconofílica, muy próxima a la iconolatría, lo que nos ubica en las antípodas del Sinaí. A partir de este contexto, se analiza el concepto de “imagen” en el Apocalipsis y, especialmente, la interpretación del teólogo Jon Paulien, quien interpreta la tercera bestia de Apocalipsis 13 —que emerge de la tierra— como una falsificación del Espíritu Santo. Tradicionalmente, la teología adventista ha identificado a esa bestia como los Estados Unidos de Norteamérica. El propósito de ese poder es hacer “grandes señales milagrosas, incluso la de hacer caer fuego del cielo a la tierra, a la vista de todos” engañando “a los habitantes de la tierra”. Sabemos que eso será posible a través de la política de Washington, pero es muy probable que también intervengan Hollywood (con sus producciones cinematográficas) y el Valle de Silicon, el centro más importante del mundo de tecnología cibernética y realidad virtual; los mayores expositores de la cultura de la imagen actual, potencialmente capaces de realizar esos prodigios impactantes a la vista.
Conversion of the Mass Audience and its Impact on the Configuration of Media
Authors: Tinka Jozef , Krulova Stefania
Published: September 2016

The influence of the information technology revolution and of the advanced communication possibilities on the development of social and mass communications is studied. It is shown that the emergence of virtual reality changed the value of time and space, and led to a new stratification of the mass audience. A new configuration of new types of audiences of different interfaces emerged. We analyzed the processes of stratification of the mass audience and their implications from the point of view of a new media typology. Attention is primarily paid to the sub-mass cell audience and to the relationship-based media (RB-media), which are the new typological phenomena, determined by the digital age. The process of emergence of the cellular audience is considered; the typological features of the RB-media are presented; and the prospects of media development are projected.
Media Communications: Evolution of the Conceptual Approaches (Part II)
Authors: Tsymbalenko Eugene
Published: September 2016

The mediated communication theories, which have the contextual connection to the media communications, are analysed. We propose the systematization of the mediated communication theories and determine the contextual links among the media communications in various fields of science. A review of the scientific literature on the conceptual approaches to the interpretation of mass and media communication is made, covering a wide range of issues, including the new strategies of self-expression and co-operation in terms of personalized communication, and the characteristics, acceptability and limitations of the new digital media in the screendigital culture. (The first paper on the results of this study was published in “Current Issues of Mass Communication”, Issue 15)
EXIAR’S EXPERIENCE IN PROVIDING INSURANCE OF EXPORT AND IMPORT OPERATIONS
Authors: Tsyganov A. A. , Kirillova N. V.
Published: September 2016

The article is devoted to the study of activity of the Russian Agency for Insurance of Export Credit and Investment (EXIAR): first results of the Agency's the Agency's activities, analysis of the key financial indicators. There are the directions in the possible privatization process EXIAR, directions of activating the output of Russian exporters in the international market and measures to improve the evaluation and improvement of financial sustainability of the agency. This article was prepared according to the results of research carried out at the expense of budget funds by the state task Financial University under the Government of Russian Federation.
THE ANALYSIS OF THE FINANCIAL CONDITION OF CITIZENS AND INDIVIDUAL ENTREPRENEURS
Authors: Kovan S. E.
Published: September 2016

Currently, the crisis management felt the need to develop a methodology for analyzing the financial condition of persons who are not a standard financial statements. The paper was developed this technique and gives examples of its application. The technique can be used to analyze the financial condition of citizens in respect of which the action is pending bankruptcy.
ANALYSIS AND ASSESSMENT OF FINANCIAL AND BUSINESS ACTIVITIES TO MINIMIZE TAX RISKS OF COMPANIES
Authors: Lyuter E. V. , Gusarova Y. V. , Starkova M. M. , Klonitskaya A. Yu.
Published: September 2016

Below is the original author's approach to the companies' tax risks valuation based on the comparison of the tax and financial statements. Algorithm of the tax risks identification based on the criteria settled by the note of the Federal Tax Authority of Russian Federation from 17.07.2013 №АС-4-2/12722 "About tax authorities committees operation on legalisation of the tax base" is described. Model of the companies classification by tax risks based on the tax burden and specific cash flow is provided.
А STUDY OF FACTORS AFFECTING THE DIFFUSION AND ACCEPTANCE OF PAYMENT SERVICES INNOVATION
Authors: Pogosyan A. M.
Published: September 2016

Non-cash payments provide a small part of total payment volume, but the usage of innovative products in named area is growing quite rapidly. The present study attempts to identify the factors determining consumers’ acceptance of payment innovation with the aim of developing a conceptual model of payment services acceptance. A research model that reflects economic, technological and socio-demographic factors are all important determinants for payment services adoption and use. Besides, there are specific correlation between them. To simulate the behavior of the consumer it was due to use parameters that reflect the actual level of awareness of innovation, the intention to use and real use of innovation. The result was the conceptual model developed in this research that focuses on factors determining consumers’ acceptance of payment services and their statement.
Knowledge and Information in Global Competition: A New Framework for Classifying and Evaluating Manipulative Communication Techniques
Authors: Sultanow Eldar , Cox Sean , Homann Sebastian , Koch Philipp , Franke Olliver
Published: September 2016

Mass media initiated exhibitions of information and knowledge streams account for a significant factor of opinion-forming in modern digitalized nations and thus influence their country's political development. Within the framework of a globalized environment, this information has the ability to shape worldwide opinion and international policy decisions across geographical boundaries. Similarly, however, information and knowledge that does not flow freely has an impact on the behind the scenes decisions of world affairs. Selective manipulation, consumed through hidden channels, is therefore a powerful tool for shaping both social and organizational environments. Currently no classification approaches exist in order to identify and evaluate this type of manipulation. Therefore, this article will discuss this type of manipulative communication and align each category into an assessment model. Forty-two varieties of manipulative arguments will be identified as well as classified along three-dimensions. A model has been developed which will serve as a tool to identify the degree and at which level manipulation was performed.
Hepatokines and non-alcoholic fatty liver disease
Authors: Lebensztejn Dariusz M. , Flisiak-Jackiewicz Marta , Białokoz-Kalinowska Irena , Bobrus-Chociej Anna , Kowalska Irina
Published: September 2016

Nowadays non-alcoholic fatty liver disease (NAFLD) is becoming the most common chronic liver pathology both in adults and children. NAFLD manifestation ranges from a simple liver steatosis to steatohepatitis (nonalcoholic steatohepatitis – NASH), which may progress to advanced fibrosis, cirrhosis and end-stage liver disease. Due to the coexistence of visceral obesity, insulin resistance and dyslipidemia, NAFLD is considered to be the hepatic manifestation of metabolic syndrome. In recent years, in the pathogenesis of metabolic syndrome, type 2 diabetes mellitus, cardiovascular disease and also NAFLD, more and more attention has been paid to the so-called organokines, proteins with both paracrine or/ and endocrine activities. These include most known adipokines (mainly produced by adipose tissue), myokines (mainly produced by skeletal muscles) and hepatokines exclusively or predominantly produced by the liver. It was shown that the liver may affect the lipids and glucose metabolism by hepatokines released into the blood and NAFLD seems to be associated with altered hepatokines production. Fetuin-A, fibroblast growth factor-21 (FGF-21), selenoprotein P, sex hormone-binding globulin (SHBG), angiopoietin-related growth factor (also known as angiopoietin-related protein 6) and leukocyte derived chemotaxin 2 (LECT2) are considered as the most important hepatokines. In this review, we provide an overview of the main hepatokines and we summarize the association of liver-derived proteins with the development and progression of NAFLD.
The supercommentator as thinker: examples from the Ashkenazic Rashi supercommentary tradition
Authors: Lawee Eric
Published: September 2016

abstract This article explores a largely neglected exegetical literary medium, supercommentaries on Rashi’s
Commentary on the Torah
. Its main aim is to show how authors who wrote in this exegetical tradition contributed to Jewish thought. The supercommentators studied are Israel Isserlein, Judah Loew of Prague (Maharal) and Isaac Horowitz. In their ensemble, these writers reflect the Ashkenazic branch of the Rashi supercommentary tradition in its medieval, early modern, and modern phases. The questions that arise in the three supercommentarial samples investigated in the article include the rationality of biblical law, the nature of human spirituality at its acme, and the tension between love of God and interpersonal love. The findings commend supercommentaries on Rashi as objects of study both for students of biblical interpretation and for scholars seeking to understand the matter, and the manner, of Jewish thinking about enduring questions.
Simon B. Scheyer (1804–1854): a forgotten pioneer of the scientific study of medieval Jewish philosophy
Authors: Freudenthal Gad
Published: September 2016

Simon B. Scheyer is one of the earliest and most distinguished pioneers of the scholarly study of medieval Jewish philosophy, especially of Maimonides, some of whose works are still used by scholars today. Despite his role as a precursor and his scholarly excellence, he has been all but forgotten by history and has not been the subject of even a single entry in any work of reference. The purpose of this article is to offer Simon Scheyer the place that is his due in the history of Jewish scholarship. I sketch his (tragic) biography, reconstituted from printed and archival sources, and present his work.
Post 2015 Development Planning: Adaption of a Holistic Approach in Planning and Research - A Commentary from a Practitioner’s Perspective
Authors: Kiambati Kellen , Itunga Julius
Published: September 2016

In this article, we analyse the argument that lack of holistic approach in planning and research have contributed to the lack of sustainable development in Africa. We base our discussion on the speech by the special advisor on the national consultation on the post 2015 development as it relates to Uganda and other African Context held on 8th August 2015. The advisor was convinced that there is a need to adopt a more integrated and comprehensive planning approach to reinventing traditional development tools and meet persistent and emerging challenges. Efforts must be made to start putting in place the practical measures, markers, mechanisms and partnerships that make sustainable advancements possible. Scholars and managers are called upon to take the challenge of demonstrating how the adoption of a holistic approach in planning, and research can contribute to sustainable development.
La magia y una nueva relación pedagógica con la infancia
Authors: Suárez Vaca María Teresa
Published: September 2016

Fundamentado en la reflexión sobre las prácticas de la autora, a la luz del estudio de literatura sobre la magia y la relación pedagógica, como también sobre trabajos investigativos, incluido su proyecto de grado para la Maestría en Educación, el artículo presenta y desarrolla analíticamente cuatro ideas: la magia en los límites de la ciencia moderna, como construcción cultural que ha retado la realidad y la imaginación; la infancia, como una dinámica del ser humano, vinculada con la curiosidad, la fuerza exploratoria, el atrevimiento, posibilidades de ser y de transformación;el maestro de la infancia en cuanto dinamizador de los procesos cognitivos y de ambientes de aprendizaje, y una nueva manera de entender la relación pedagógica con la infancia, que se plantea a partir del examen crítico de la anterior información.
Cine y pedagogía: reflexiones a propósito de la formación de maestros
Authors: Osorio Angélica Del Pilar , Rodríguez Víctor Manuel
Published: September 2016

El artículo, que es producto del proceso de investigación realizado en el marco del proyecto El cine como posibilidad de pensamiento desde la pedagogía: una mirada a la formación de maestros1; aborda el lugar del cine en las sociedades contemporáneas y sus relaciones con la pedagogía y la formación de maestros, y propone la formación como experiencia y no como un continuum externo a los sujetos.Desde allí se construyen unas consideraciones en torno al cine, la pedagogía y el poder en el contexto de las sociedades de imagen, y posteriormente se abordan las relaciones entre formación,cine y pedagogía, contando con la experiencia y la lectura del cine como conceptos articuladores para pensar las prácticas de innovación en educación como campo de problematización.
La investigación como estrategia pedagógica una apuesta por construir pedagogías críticas en el siglo xxi
Authors: Mejía Jimenéz, Marcos Raúl , Manjarrés María Elena
Published: September 2016

El texto busca fundar la idea de que llevar la investigación a la esfera educativa y pedagógica va a generar una reelaboración del campo de éstas, así como de los mecanismos prácticos y de acción que las han constituido. En primer lugar se realiza un rápido recorrido para reconocer la manera como se han constituido la educación y la pedagogía en la modernidad capitalista occidental; en él se observan los paradigmas, corrientes, concepciones, enfoques y líneas metodológicas y modelos, como aspectos que vertebran estas búsquedas; luego se muestra la manera como se conformó el pensamiento pedagógico en torno a la investigación, el cual da origen a diversas entradas metodológicas para ser resuelto en el cotidiano de las prácticas de los educadores; por último, se fundamenta una de esas líneas metodológicas, la de la Investigación como Estrategia Pedagógica (IEP), surgida en las construcciones de las pedagogías críticas desarrolladas en las realidades latinoamericanas y en diálogo con los enfoques surgidos y dinamizados en diferentes latitudes mundiales
Estudio de caso: una estrategia para la enseñanza de la educación ambiental
Authors: Niño Barajas Leomary
Published: September 2016

La Educación Ambiental tiene como objetivo favorecer la formación de sujetos sensibles por el medio ambiente, con capacidad para construir conocimientos y adoptar posiciones críticas y reflexivas que les permita la toma de decisiones frente a problemáticas del entorno. En una sociedad donde la explotación masiva de recursos naturales evidencia el uso irracional y desmedido que el hombre ha hecho sobre los ecosistemas, la enseñanza de las Ciencias Naturales dentro del marco de la Educación Ambiental debe estar dirigida a promover acciones y conductas éticas, sobre el uso y cuidado del medio natural. Así, el presente artículo contempla, dentro de un proceso de investigación - acción, la reflexión sobre la enseñanza de las Ciencias Naturales en la educación básica, su articulación con la Educación Ambiental y finalmente, la aplicación del estudio de caso como estrategia didáctica que favorece el desarrollo del carácter epistemológico y metacognitivo de la alfabetización científica, al permitir que estas disciplinas puedan entrecruzarse y complementarse, y contribuir a la reflexión sistémica sobre la práctica social y educativa con vistas a mejorar el entorno y la calidad de vida.
Editorial
Authors: Gordo Contreras Aurora
Published: September 2016

El arte es la vida Con el ánimo de crear un espacio de referencia sobre la Investigación y la Educación en Artes y Humanidades, la línea de Investigación, Creación y Pedagogía de la Maestría en Educación, presenta una revisión actualizada de los discursos, imaginarios y prácticas de su campo de estudio dentro delcontexto colombiano y latinoamericano en el número seis de la Revista Praxis & Saber; y no puedo desaprovechar el momento para hablar de cómo inició el proceso investigativo en mí. Fue mi padre quien siempre desde niños nos ayudó a encontrar el sentido de la vida y de las cosas. Todo lo resolvía y lo contestaba con preguntas con el fin de que averiguáramos en muchos campos, incluyendo los del espíritu, los de los sentidos y los del corazón, donde confluían el sueño y la reflexión; siempre vi a mi padre como el maestro que ponía a dialogar el pensamiento con la imaginación.
Culturas del espacio y procesos artísticos colectivos - participativos. Casos recientes en México D.F., Bogotá D.C. y Medellín
Authors: Escobar Neira Fernando
Published: September 2016

El presente artículo aborda distintos aspectos relacionados con la espacialización de algunos casos de prácticas artísticas colectivas y participativas en lugares específicos de tres ciudades latinoamericanas: México D.F., Bogotá D.C. y Medellín. El texto problematiza la presencia de distintos idearios y representaciones sociales de lo artístico en sus dimensiones local y global, que establecen significados de lo artístico, de lo político y lo social, que pugnan al asociarse a ciertas prácticas artísticas contemporáneas, sus agentes e instituciones. Para esto, propone una entrada que se aparta un poco de la teoría e historia del arte, situándose en un ir y venir constante entre los supuestos de las prácticas artísticas y las ciencias sociales.
Foros virtuales, formas dialógicas entre artistas y espectadores —caso Fincortex—
Authors: Moreno Ospina Jairo
Published: September 2016

Fincortex se constituye como un festival de cortometrajes interesado en el desarrollo de éstos, en el estímulo de su producción, y en la formación de públicos. Conscientes del actual desarrollo tecnológico que ha generado cambios en losroles de creadores y espectadores, en tanto tiene que ver con sus actitudes frente a los productos artísticos, se visualiza cómo han sido esas transformaciones en cuanto al arte audiovisual desde los inicios del cine hasta la actualidad,las actitudes y compromisos que ha adquirido el artista frente a los cambios socioculturales, asimismo los espectadores, al proponérseles nuevas actitudes frente a las propuestas que seles presentan. En este panorama, se propone la creación de foros virtuales que acompañen las propuestas audiovisuales para que sean discutidas desde diálogos horizontales y así consolidar una comunidad interesada por estos productosculturales.
Historia de vida: cuando entendí que aprender cosas nuevas en la escuela de artes lleva más tiempo
Authors: López Niño Ángela Paola
Published: September 2016

Nací el 16 de abril de 1984 en la ciudad de Tunja, en un hogar conformado por mi padre, mi madre y mis dos hermanos mayores. A los dos años de edad me diagnosticaron hipoacusia bilateral severa con una pérdida auditiva del 90%, pérdida total del lenguaje, autismo y disfasia cerebral. Por esta razón a los dos años comencé un tratamiento terapéutico en el centro fonoaudiológico de Tunja, pero luego de un tiempo me negaron el servicio porque yo no progresaba, según ellos yo “le estaba quitando el cupo a otros niños”, así fui excluida de un tratamiento que era importante y valiosopara mi vida. Este trabajo terapéutico constaba de fonoaudiología, terapia ocupacional y atención con psicología durante cinco días a la semana. Algunas sesiones eran individuales y otras en grupo, que estaba conformado por niños con síndrome de Down, con autismo, con parálisis cerebral y con retraso mental. Todos tenían distintas edades,desde bebés de meses y niños hasta seis años.
Note on forgotten topological index of chemical structure in drugs
Authors: Ramane Harishchandra S. , Jummannaver Raju B.
Published: September 2016

The forgotten topological index of a graph G is defined as the sum of the cube of the degrees of its vertices. In the recent paper [6], [W. Gao et al. (2016), Forgotten topological index of chemical structure in drugs, Saudi Pharmaceutical Journal, 24, 258-264], the forgotten topological index of some chemical structures has been obtained. In this note, we correct their result regarding triangular benzenoid. Also, we have given the expression for the forgotten topological index of graphene structure which is more compact than the one was obtained in the paper above.
Respeito aos precedentes judiciais iterativos pela Administração Pública
Authors: Freitas Juarez
Published: September 2016

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O novo regime do servidor público estatal
Authors: Freitas Juarez
Published: September 2016

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As modernas parcerias públicas com o Terceiro Setor
Authors: Sundfeld Carlos Ari , Souza Rodrigo Pagani de
Published: September 2016

Este estudo pretende demonstrar que os modernos vínculos de parceria do Estado com o Terceiro Setor já têm conteúdo que os aproxima de verdadeiros contratos administrativos, voltados à prestação de serviços de relevância pública. Mas é preciso que a legislação torne mais sistemático o tratamento dessas parcerias como contratos. Além disso, é necessário disciplinar, por lei, um processo administrativo de chamamento público adequado à celebração desses contratos.
A legitimidade do Estado Regulador brasileiro: uma análise democrática
Authors: Duarte Júnior Ricardo César Ferreira
Published: September 2016

O presente trabalho apresenta um estudo sobre a legitimidade da regulação econômica na Constituição Federal de 1988. Busca-se fazer uma análise das normas constitucionais com base na interpretação sistemática dessas e no fenômeno da mutação constitucional (específico de um direito dogmático e autônomo, como o atual) para alcançar a legitimidade das decisões proferidas pelas agências  reguladoras. Tem-se que a legitimidade deste processo decisório consiste, em última análise, na própria legitimidade do sistema regulatório econômico. Nesse contexto, verificar-se-á que, não obstante a argumentação de “déficit democrático” nas agências, a legitimidade da regulação econômica é alcançada pela participação popular nos procedimentos normativos em sede desses entes regulatórios.
Globalización, pluralidad sistémica y Derecho Administrativo: Apuntes para un Derecho Administrativo Multidimensional
Authors: Reyna Justo J.
Published: September 2016

Proponer, en tiempos de globalización y transversalidad del derecho,  una línea de análisis para que las Administraciones de distinto orden jurídico puedan actuar, junto a particulares,  de modo sincronizado y sinérgico. Actuar de modo rápido y eficaz conforme a un régimen jurídico impuesto por el caso y el derecho en red. El Derecho Administrativo Multidimensional es el objetivo de la propuesta. Lo entiendo  como un régimen jurídico complejo, especial y derivado que regula la organización y actuación sincronizada de administraciones públicas de distintas dimensiones jurídicas y de particulares, conectados jurídicamente por portales dimensionales correspondientes a un caso determinado. Es un punto de encuentro de sistemas jurídicos. Sobre las premisas del neoconstitucionalismo  se modula, entre otros aspectos,  la relación clásica entre los actores jurídicos del derecho administrativo y la ley en sentido amplio.
A legitimidade da ANVISA para a regulação da publicidade de alimentos
Authors: Reis Sérgio L. B. F.
Published: September 2016

Este artigo analisa a legitimidade da regulação da publicidade de alimentos pelo Estado, mais especificamente pela agência reguladora federal responsável por regular vigilância sanitária, a ANVISA.  A importância deste assunto está intimamente relacionado ao direito à informação, um direito do consumidor e do cidadão, assim como uma questão de saúde pública uma vez que os hábitos alimentares da população se alteraram.  Infelizmente, as alterações não foram para melhor como pode ser observado pelo crescente número de cidadãos com problemas de saúde e a tendência de aumento dos gastos com saúde pelo Estado.  A regulação da publicidade de alimentos tem as características de uma política pública preventiva em um tema de grande relevância.
A concessão administrativa nos serviços de relevância social
Authors: Belem Bruno Moraes Faria Monteiro
Published: September 2016

Os fatores que provocaram o surgimento das parcerias público-privadas foram: i) a insuficiência de infraestrutura, que, na generalidade, é uma das principais causas do impedimento ou da interrupção do crescimento econômico do país, bem como do acesso às prestações inerentes aos direitos sociais; e ii) a existência de atividades de relevância coletiva para cuja execução se fazem necessários investimentos vultosos em infraestrutura e que não podem ser suportados pelo Estado porque não são financeiramente autossustentáveis. Nesse contexto de recursos escassos e necessidades básicas que merecem ser atendidas, a configuração que melhor parece atender à vocação da concessão administrativa no domínio dos direitos de relevância social é a delegação da execução de serviço precedida de obra pública, modelo capaz de promover a criação de infraestrutura sem dispêndio imediato de recursos públicos. Num contexto em que os direitos sociais foram amplamente positivados e os recursos públicos são escassos ou pelo menos não parecem ser suficientes para fazer frente, no tempo desejado, às necessidades sociais, a colaboração entre o setor público e o setor privado parece ser um novo modelo para a criação e gestão dos serviços considerados de relevância social.
Ações afirmativas no ensino superior: uma abordagem da realidade brasileira sob o enfoque legislativo e jurisprudencial
Authors: Costa Rafael Santiago
Published: September 2016

O estudo aborda as ações afirmativas que vêm sendo desenvolvidas no Brasil no que diz respeito ao ensino superior. Dois aspectos são tratados com maior ênfase, referindo-se ao tratamento que vem sendo atribuído ao tema no Brasil pelo legislador e pelo Poder Judiciário. Como não poderia ser diferente, especial atenção é atribuída à questão das cotas raciais, apontando-se de forma resumida os principais argumentos contrários e favoráveis a políticas dessa natureza que costumam ser invocados pelos debatedores do tema.
O Direito Administrativo do século XXI: um instrumento de realização da democracia substantiva
Authors: Moreira Neto Diogo De Figueiredo
Published: September 2016

O presente ensaio tem como objeto a análise das relações entre poder, política, Direito e democracia nas sociedades contemporâneas, avaliando os seus reflexos no Direito Administrativo e traçando perspectivas para esse ramo jurídico no século XXI.
Sustentabilidade das escolhas públicas: dignidade da pessoa traduzida pelo planejamento público
Authors: Valle Vanice Regina Lírio do
Published: September 2016

Equilíbrio e harmonia entre poderes, embora seja uma velha cláusula relacionada ao controle do poder, é ainda uma limitação à deliberação política que gera reações, especialmente quando se cuida de supervisão técnica a esse tipo de decisão. O surgimento da sustentabilidade como característica a ser exigida das escolhas públicas certamente estabelece novos ângulos no que toca ao controle de agente públicos – especialmente quando se tem consciência de que sustentabilidade está intimamente relacionada com a dignidade da pessoa humana como valor constitucional. Eficiência dinâmica e resultados legítimos são aspectos novos que devem ser considerados quando se cuida de formulação de escolhas públicas, exigindo portanto uma Administração Pública que opera através de um planejamento abrangente que compreenda não só avaliação econômica, mas também benefícios sociais.
A aplicação dos princípios de Direito Penal no Direito Administrativo: uma análise do princípio da insignificância econômica
Authors: Blanchet Luiz Alberto , Gabardo Emerson
Published: September 2016

Este estudo tem por objetivo analisar a possibilidade e vantajosidade da aplicação no Direito Administrativo de diversos princípios entendidos tradicionalmente como restritos ao Direito Penal, com particular ênfase ao princípio da insignificância econômica. Com base em recentes julgados dos Tribunais Superiores e doutrina, busca-se repelir argumentos contrários à posição de que não haveria um regime constitucional sancionatório único, envolvendo os dois ramos do Direito. Amparado ainda na natureza humana dos agentes da administração pública, demonstra-se a importância de se considerar os valores de inexigibilidade de conduta diversa e proporcionalidade para identificar e delimitar os ilícitos.
O casamento da supremacia legislativa com a Jurisdição Constitucional: lições da Grã-Bretanha para o Brasil
Authors: Chehab Gustavo Carvalho
Published: September 2016

Discute-se o modelo tradicional de Jurisdição Constitucional em face da supremacia legislativa adotada no modelo britânico de controle de constitucionalidade. Para isso, faz-se um estudo sobre as linhas gerais das características comuns dos modelos de constitucionalidade existentes no mundo e uma análise da tradição Parlamentar britânica e do seu constitucionalismo. Apresenta-se o atual método britânico de controle de constitucionalidade para contrapor, dialeticamente, ao modelo brasileiro. Finalmente, procura-se suscitar novas luzes sobre o atual e permanente problema da legitimidade da jurisdição constitucional.
La participación en el Estado social y democrático de Derecho
Authors: Muñoz Jaime Rodríguez-Arana
Published: September 2016

El artículo tiene como objetivo examinar la cuestión de la participación ciudadana en el Estado Democrático y Social de Derecho. El tema se estudia desde la perspectiva del interés general, del contexto del Estado de Bienestar, de la reforma del Estado y su impacto en la participación, entendida como objetivo y como método, siempre desde la perspectiva de la dignidad humana y de los derechos fundamentales.