bluuebunny/crossref_metadata_2025 huggingface dataset:
A Study of the Antitumour Activity of FourTriorganophosphinegold(I) Thiolates: R3PAu(SR′), R = Ph, Cy, Et; SR′H = 6‐Mercaptopurine and R = Et; SR′H =6‐Thioguanine
Authors: Crump David , Siasios George , Tiekink Edward R. T.
Published: March 2007

The antitumour activities of four triorganophosphinegold(I) thiolates, R3PAu(S′R) [R = Ph, Cy, Et; SR′H = 6‐mercaptopurine and R Et; SR′H = 6‐thioguanine] against the National Cancer Institute (NCI) panel of 60 cell lines are reported The [Cy3PAu(6‐MP)]
complex proved to be the more cytotoxic of the four complexes tested. For the 6‐MP series, an order of cytotoxicity was established such that the activity followed the order R = Cy > Ph > Et. Sub‐panel selectivity against the Leukemia cell lines was found for each of [Cy3PAu(6‐MP)]
and [Et3PAu(6‐TG)].
Synthesis and Anti‐Candida Activity of Cobalt(II) Complexes ofBenzene‐1,2‐Dioxyacetic Acid (bdoaH2). X‐Ray Crystal Structures of [Co(bdoa)(H2O)3]⋅3.5H2O and {[CO(phen)3](bdoa)} 2⋅24H2O (phen = 1,10‐Phenanthroline)
Authors: Geraghty Majella , McCann Malachy , Devereux Michael , Cronin Fergal , Curran Martin , McKee Vickie
Published: March 2007

reacts with benzene‐1,2‐dioxyacetic acid (bdoaH2)
to give the Co2+
complexes
(1a) and
(1b). Subsequent reaction of 1a with 1,10‐
phenanthroline produces [CO(phen)3]bdoa · 10H2O
(2a) and
(2b). Molecular
structures of 1b and 2b were determined crystallographically. In 1b the bdoa2-
ligates the metal by two
carboxylate oxygens and two ethereal oxygens, whereas in 2b the bdoa2-
is uncoordinated. The Mn2+
and
Cu2+ 
complexes [Mn(bdoa)(phen)2] · H2O
(3) and [Cu(pdoa)(imid)2]
(4) were also synthesised, 1a-4 and
other metal complexes of bdoaH2
(metal = Mn2+, Co2+ ,Cu2+, Cu+
) were screened for their ability to inhibit
the growth ofhe yeast Candida albicans. Complexes incorporating the 1,10‐phenanthroline ligand were the
most active.
A Review on the Radioprotective Activity of organogermanium andOrganosilicon Compounds
Authors: Rima Ghassoub , Satgé Jacques , Dagiral Rodolphe , Lion Claude , Sentenac-Roumanou Henri , Fatôme Marc , Roman Vincent , Laval Jean-Denis
Published: March 2007

The present review describes the work carried out during the last 20 years in the field of the
radioprotective activity and toxicity of several classes of organosilicon and organogermanium
compounds (i.e. metallathiazolidines, metalladithioacetals, metallatranes and germathianes).
A 5′‐Phosphodiester Group Attached to Deoxyguanosine does notAccelerate the Hydrolysis of cis‐[PtCl(NH3)2(dGuo)] +
Authors: Weber Tiphaine , Legendre Franck , Novozamsky Veronika , Kozelka Jiří
Published: March 2007

The influence of the methylphosphoester group on the reversible reaction shown below was studied.
Evaluation of the rate constants for the system depicted as well as for the analogous equilibrium involving
the nucleoside deoxyguanosine showed that whereas the chloride anation is slowed down by the presence of
the methylphosphoester group, the hydrolysis rate constant is not significantly altered. This result speaks
against a catalytic role of the 5′‐phosphodiester group in the hydrolysis of cisplatin monoadducts with DNA,
as suggested previously (Kozelka & Barre, Chem. Eur. J. 1997, 3, 1405‐1409).
Ni (II), Cu (II) and Zn (II) Metal Chelates With Some ThiazoleDerived Schiff‐Bases: Their Synthesis, Characterization andBactericidal Properties
Authors: Chohan Zahid H.
Published: March 2007

A number of thiazole derived tridentate Schiff‐bases (LH) and its metal chelates of the type [M(L)2X]
where M=Ni(II), Cu(II) and Zn(II), L=substituted salicylaldehyde (5‐H, 5‐CH3, 5‐OCH3, 5‐NO2
and 5‐Cl) and X=CI have been synthesized and characterized with the help of elemental analyses, conductivity measurements, magnetic moments, UV‐Vis, IR and NMR spectral data. An octahedral structure for Ni(II) and Zn(II) and a distorted octahedral structure for Cu(II) chelates have been proposed. All the Schiff‐bases and their metal chelates have been screened for their biological activity against Escherichia coli, Staphylococcus aureous , Pseudomonas aeruginosa and Klebsiella pneumonae and in comparison, the metal chelates have been shown to possess more antibacterial activity than the uncomplexed Schiff‐bases.
Synthesis, Spectroscopy and Electrochemistry of Fe(II) and Fe(III)Quinonemonooxime Complexes and Their DNA Cleaving Activities
Authors: Murugkar Anupa , Padhye Subhash , Deobagkar Deepti
Published: March 2007

Iron(II) and iron(III) complexes of 3,5‐di‐tert‐butyl‐o‐benzoquinonemonooxime were synthesized and
characterized by spectroscopic and electrochemical studies. Their ability to cleave DNA has been investigated
under aerobic conditions at room temperature and in the presence and absence of H2O2
. The plasmid DNA
pBR322 was effectively cleaved by these complexes in a concentration dependant manner.
Effects of Long‐Term Administration of Lithium andHydrochlorothiazide in Rats
Authors: Loghin Felicia , Olinic Adriana , Popa Daniela-Saveta , Socaciu Carmen , Leucuta Sorin E.
Published: March 2007

The biochemical and histological changes following 60 days administration of daily doses
equivalent to 1/20 LD50
of lithium lactate and hydrochlorothiazide, as such and in
association, were studied in male Wistar rats. No mortality or overt signs of toxicity were
observed during the experiment and the serum activities of transaminases, alkaline
phosphatase and cholinesterase were not significantly modified compared to controls. The
histopathological examination of all the investigated organs: kidney, liver, brain and spleen,
revealed significant lesions which were time‐dependant and more pronounced in the
association group. Although the changes were mostly inflammatory and conqestive, it was
proved that the concomitant administration of lithium and hydrochlorothiazid is potentially
dangerous, increasing lithium’s nephrotoxicity and the thiazide diuretic′s hepatotoxicity.
Synthetic, Spectroscopic and Biocidal Aspects of Heterobimetallic Complexes Comprising Platinum(II) and a Group Four or Fourteen Element
Authors: Sharma Kripa , Singh R. V.
Published: March 2007

Heterobimetallic complexes with varying amines have been synthesized by the reaction of [Pt]Cl2 with group four or fourteen organometallic dichlorides, viz., R2MCl2 and Cp2M′Cl2 in a 1:2 molar ratio in MeOH (where M=Si or Sn, M′= Ti or Zr and R=Ph or Me). These complexes have been characterized by elemental analysis, molecular weight determinations, magnetic measurements, conductance, IR,  1H NMR and electronic spectra. The spectral data suggest a square planar geometry for all the complexes. Conductivity data suggest that they behave as electrolytes. These monometallic precursors along with their complexes have been screened in vitro against a number of pathogenic fungi and bacteria to assess their growth inhibiting potential.
Biological Activity of Some Magnesium(II) Complexes of Quinolones
Authors: Turel Iztok , Šonc Andrej , Zupančič Marija , Sepčić Kristina , Turk Tom
Published: March 2007

A new magnesium complex of quinolone antibacterial agent was prepared. This new complex as well as a previously isolated complex of magnesium with ciprofloxacin were tested against various Gram positive and Gram negative microorganisms. Antimicrobial activities were evaluated using the agar diffusion test. The results have shown that all magnesium complexes are significantly less active than the parent quinolone drugs. It was also found that the activity of quinolones is reduced when the solutions of quinolones are titrated with magnesium ions.
Fertility Inhibitor Heterobimetallic Complexes of Platinum(II) and Palladium(II): Synthetic, Spectroscopic and Antimicrobial Aspects
Authors: Sharma Kripa , Joshi S. C. , Singh R. V.
Published: March 2007

Synthetic, spectroscopic and antimicrobial aspects of some fertility inhibitor heterobimetallic complexes have been carried out. These heterobimetallic chelates [M(C5H5N3)2M2′(R)4]Cl2 (M = Pd or Pt and M′ = Si, Sn, Ti and Zr) have been successfully synthesinzed via the reaction of M(C5H7N3)2Cl2 with group four or fourteen dichlorides in 1:2 stoichiometric proportions. The products were characterized by elemental analyses, molecular weight determinations, magnetic susceptibility measurements, conductance, and IR multinuclear NMR and electronic spectral studies. A square planar geometry has been suggested for all the complexes with the help of spectral data. Conductivity data strongly suggest that chlorine atoms are ionic in nature due to which complexes behave as electrolytes. All the complexes have been evaluated for their antmicrobial effects on different species of pathogenic fungi and bacteria. The testicular sperm density, testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trails and biochemical parameters of reproductive organs have been examined and discussed.
Role of Vitamin D on the Inhibition of Gastrin Production After Cisplatin Treatment
Authors: Wang Ying , Aggarwal Surinder K. , Kopachik Will
Published: March 2007

In rats cisplatin induces hypocalcemia, bloating of the stomach, and ulceration ameliorated through calcium supplements. This study was undertaken to test the role of calcium on the gastrin mRNA production in vitro and in vivo. RIN B6 cells were cultured in medium with calcium (1.8, 3.6 and 7.2 mM) and the active form of vitamin D (calcijex). Cisplatin was added (10 μg/ml) for 12 hrs and cells were harvested for RNA from various treatment groups. Male Wistar rats were treated with cisplatin (9 mg/kg), before and after vitamin D (0.3 mg/100g/week). The rats were killed and stomach tissues excised on 1, 6, 10 and 15 days after cisplatin treatment. RNA from the stomach was analyzed using the northern blot technique. Gastrin mRNA was suppressed after cisplatin treatment both in vitro and in vivo. In vitro calcium but not vitamin D additions partially prevented the gastrin mRNA. In vivo, however, vitamin D and calcium were equally effective in preventing gastrin mRNA loss.
Zinc(II) Complexes ‐ A New Group of Non‐Mutagenic Herpes Simplex Virus Inhibitors
Authors: Pesheva Margarita , Varadinova Tatiana
Published: March 2007

Former studies showed that complexes of Zn(II) with picolinic and with aspartic acids, Zn(pic)2 and Zn(asp)2, are able to inhibit HSV infection in cultured cells by affecting key steps of virus replication. As these complexes are candidates for a novel class anti‐HSV drugs, further studies on their mutagenicity are of particular interest. In the present paper we present data showing that Zn(pic)2 and Zn(asp)2 do not express mutagenic effect in both prokaryotic (Salmonella typhimurium) and eukaryotic (Saccharomices cerevisiae) test systems.
Synthesis, Characterization and Biological Properties of Anions of Bivalent Transition Metal [Co(II) and Ni(II)] Complexes With Acylhydrazine Derived ONO Donor Schiff Bases
Authors: Chohan Zahid H. , Farooq M. A. , Iqbal M. S.
Published: March 2007

Some acylhydrazine derived ONO donor Schiff bases and their Co(II) and Ni(II) complexes have been prepared having the same metal ion (cation) but different anions. These synthesized metal(II) complexes have been characterized on the basis of their elemental analyses, magnetic moment, molar conductance, and IR and electronic spectral data. All of the Schiff base ligands function as tridentates and the deprotonated enolic form is preferred for coordination. In order to evaluate the effect of anions on the bactericidal activity, these synthesized complexes, in comparison to the uncomplexed Schiff bases have been screened against bacterial species., Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa and the results are reported.
C‐3 Substituted Lawsonemonoximates of Holmium(III): Synthesis, Characterization, and Antimicrobial Activity
Authors: Jagtap S. B. , Joshi S. G. , Litake G. M. , Ghole V. S. , Kulkarni B. A.
Published: March 2007

A series of five new metal complexes of Ho(III) with C‐3 substituted derivatives of lawsonemonexime (2‐hydroxy‐1,4‐naphthalenediene‐1‐oxime) were synthesized. The compounds were characterized by melting point, elemental analysis, IR spectroscopy and magnetic susceptibility. The antimicrobial activity of the compounds were determined by disk diffusion method and broth micro‐dilution techniques using Mueller Hinton medium against the following organisms: S. aureus ATCC 6538P, Klebsiella pneumoniae, NCTC 418, Pseudomonas aeruginosa ATCC 27833, Salmonella typhimurium ATCC 23564, E. coli U 1777, E. coli HB101, Proteus morganii NCIM 2860, Providencia stuartii NCIM 2799 and Acinetobacter baumannii U 24. The chelates of Ho(III) with lawsonemonoxime and Ho(III) with 3‐bromolawsonemonoxime showed a variable antimicrobial activity against all organisms tested except Pseudomonas and Klebsiella spp. S. aureus was found more sensitive to all ligands and chelates tested; but the MIC values of chelates were considerably less; thus having more antimicrobial effect.
Antitumor Trans Platinum Adducts of GMP and AMP
Authors: Liu Yangzhong , Sivo Maria F. , Natile Giovanni , Sletten Einar
Published: March 2007

Recently it has been shown that several analogues of the clinically ineffective trans‐DDP exhibit antitumor activity comparable to that of cis‐DDP. The present paper describes the binding of antitumor trans‐[PtCl2(E‐iminoether)2] (trans-EE) to guanosinemonophosphate (GMP) and adenosinemonophosphate (AMP). We have used HPLC and  1H and  15N NMR to characterize the different adducts. In the case of a 1:1 mixture of trans-EE and GMP, at an early stage of the reaction, a monofunctional adduct is formed which, subsequently, is partly converted into a monosolvated monofunctional species. After about 70 hours an equilibrium is established between chloro and solvato monofunctional adducts at a ratio of 30/70. In the presence of excess GMP (4:1) the initially formed monofunctional adducts react further to give two bifunctional adducts, one with the iminoether ligands in their original E configurations and the other with the iminoether ligands having one E and the other, Z configurations. The coordination geometry obtained by energy minimization calculations is in qualitative agreement with 2D NMR data.
Symmetric 1,1′‐Dimethylferrocene‐Derived Amino Acids: Their Synthesis, Characterization, Ligational and Biological Properties With Cu(II), Co(II) and Ni(II) Ions
Authors: Chohan Zahid H.
Published: March 2007

Some novel symmetric 1,1′‐dimethylferrocene derived amino acids have been prepared by the reaction of
1,1′‐ferrocenedimethyldichloride with amino acids (glycine, alanine, phenylalanine and tyrosine). Their
Cu(II), Co(II) and Ni(II) complexes, of the type [M(L)] where [M = Cu(II) and L = L1‐L5] and [M(L)Cl2] where
[M‐Co(II)and Ni(II), L = L1‐L5] have been prepared. The dicarboxylic acids and their metal complexes were
characterized by their physical, analytical and spectral data. The [M(L)] complexes showed a square planar
geometry whereas an octahedral geometry was observed for [M(L)Cl2] complexes. The title dicarboxylic
acids and their metal complexes have also been screened for their antibacterial activity.
Biological Properties of IRIM, the Iridium(III) Analogue of (Imidazolium (Bisimidazole) Tetrachlororuthenate) (ICR)
Authors: Marcon G. , Casini A. , Mura P. , Messori L. , Bergamo A. , Orioli P.
Published: March 2007

Some biological aspects of the new complex imidazolium bisimidazole tetrachloro iridate(III)‐IRIM‐ the iridium(III) analogue of ICR, were considered. More in detail the conformational effects produced by IRIM on DNA and the cytotoxic properties of IRIM on some selected human cell lines were measured.
Dialysis experiments and DNA thermal denaturation studies are suggestive of poor binding of IRIM to DNA;
formation of interstrand crosslinks is not observed. In any case CD measurements suggest that addition of
increasing amounts of IRIM to calf thymus DNA results into significant spectral changes, that are diagnostic
of a direct interaction with DNA. A number of experiments carried out on the A2780 human ovarian carcinoma,
B16 murine melanoma, MCF7 and TS mammary adenocarcinoma tumor cell lines strongly point out
that IRIM does not exhibit significant growth inhibition effects within the concentration range 10-4‐10-6 M. It
is suggested that the lower biological effects of IRIM compared to ICR are a consequence of the larger kinetic
inertness of the iridium(III) center with respect to ruthenium(III).
Interaction of [Rh2(O2CCH3)4(H2O)2] and [Rh2(O2CCH(OH)Ph)2(phen)2(H2O)2](O2C‐CH(OH)Ph)2 With Sulfhydryl Compounds and Ceruloplasmin
Authors: Jakimowicz Piotr , Ostropolska Lucja , Pruchnik Florian P.
Published: March 2007

The interaction of binuclear rhodium(II) complexes [Rh2(OOCCH3)4(H2O)2], [Rh2{OOCCH(OH)Ph}2(phen)2(H2O)2] {OOCCH(OH)Ph}2, [Rh2(OOCCH3)2(bpy)2(H2O)2](OOCCH3)2 and [Rh2Cl2(OOCMe)2(bpy)2](3H2O) with ceruloplasmin, cysteine, glutathione and coenzyme A have been
investigated using. UV‐Vis and CD spectroscopies. The complexes containing phen or bpy at pH = 7.4 and
4.0 are readily reduced with sulfhydryl compounds, while rhodium(II) acetate is relatively stable in these
conditions. Complex [Rh2{OOCCH(OH)Ph}2(phen)2(H2O)2] strongly changes structure of ceruloplasmin
leading to the decrease of of α‐helix content and loss of oxidase activity.
Toxicity, Spectroscopic Characterization and Electrochemical Behaviour of New Macrocclic Complexes of Lead(II) and Palladium(II) Metals
Authors: Bansal Anil , Singh Randhir , Singh R. V.
Published: March 2007

Tetraazamacrocyclie complexes of lead and palladium have been synthesized by the template
process using the bis(benzil)ethylenediamine precursor. The tetradentate macrocycle (maL) reacts with
PbCl2, PdCl2 and different diamines in a 1:1:1 molar ratio in methanol to give several solid complexes of the
types [Pb(maL)(R)Cl2] and [Pd(maL)(R)]Cl2 (where R = 2,6‐diaminopyridine or 1,2‐phenylenediamine). The
macrocycle and its metal complexes have been characterized by elemental analysis, molecular weight
determinations, molar conductivity, IR, 1H NMR, 13C NMR, electronic, mass and electrochemical studies. The
macrocyclic ligand coordinates through the four azomethine nitrogen atoms which are bridged by benzil
moieties. IR spectra suggest that the pyridine nitrogen is not coordinating. The palladium complexes exhibit
tetracoordinated square‐planar geometry, whereas a hexacoordinated octahedral geometry is suggested for
lead complexes. The macrocycle along with its complexes have been screened in vitro against a number of
pathogenic fungi and bacteria to assess their growth inhibiting potential.
Synthesis, Characterization and Antifertility Activity of New Unsymmetrical Macrocyclic Complexes of Tin(II)
Authors: Sharma Kripa , Joshi S. C. , Singh R. V.
Published: March 2007

A new series of unsymmetrical macrocyclic complexes of tin(ll) has been prepared by the template process using bis(3‐oxo‐2‐butylidene)propane‐1,3‐diamine as precursor. This affords a method to synthesize these complexes with various ring sizes. The tetradentate macrocyclic precursor [N4mL] reacts with SnCl2 and different diamines in a 1:1:1 molar ratio in refluxing methanol to give complexes of the type [Sn(N4mL)Cl2]. The ring expansion has been achieved by varying the diamine between the two diacetyl amino nitrogen atoms. The macrocyclic precursor and its metal complexes have been characterized on the basis of elemental analysis, molar conductance, molecular weight determinations, IR,  1H NMR, 13C NMR,  119Sn NMR and electronic spectral studies. An octahedral geometry around the metal ion is suggested for these complexes. On the basis of molecular weights and conductivity measurements, their monomeric and non‐electrolytic nature has been confirmed. The precursor and complexes have been screened in vitro against a number of pathogenic fungi and bacteria to assess their growth inhibiting potential. The testicular sperm density and testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trails and biochemicals parameters of reproductive organs have been examined and discussed.
High In-Vitro Antitumour Activity of Triphenyltin Coumarin 3‐Carboxylate and its Coordination Complexes With Monodentate Oxygen Donor Ligands Against the Epstein Barr Virus (EBV)‐DNA Positive Raji and the P‐388 Murine Leukaemia Cell Lines, and Evidence for the Suppression by Organotin of the Early Antigen Complex in the EBV Lytic Cycle
Authors: Koshy Joyce , Das V. G. Kumar , Balabaskaran S. , Ng S. W. , Wahab Norhanom
Published: March 2007

Triphenyltin coumarin‐3‐carboxylate and its coordination complexes with ethanol, triphenylphosphine oxide, triphenylarsine oxide, diphenylcyclopropenone and quinoline N‐oxide exhibited high in vitro cytotoxicity (LC50 values in the range 0.25‐3.4 μg/mL) when tested against EBV‐DNA positive Raji cells and P‐388 leukaemia cells, compared to the standard drug 5‐Fluorouracil, which showed LC50 values of 11 and >50 μg/mL, respectively, against these cells. Additional tests performed on the Raji cells incubated with the quinoline N‐oxide complex in the presence of the tumour promoters, TPA and sodium butyrate, revealed that the diffused and restricted protein components of the early antigen complex were suppressed relative to the control containing only the promoters, indicating impaired function of the genes involved as transactivators in the early lytic cycle of the EBV. The failure of the restriction enzymes Eco R1 and Hind III to cleave the extracted DNA from such treated cells in contrast to the control, coupled with the amplification of the BMLF‐1 gene by the PCR technique which was realised only with the DNA of the control and not of the treated sample, point to a punitive interaction of the organotin with the nuclear DNA of the Raji cells.
Increased Efficacy of Zinc Complexes With Picolinic and Aspartic Acids Against Herpes Simplex Virus (HSV) Infection When Combined With the Pavine Alkaloid (‐)‐Thalimonine
Authors: Angelova Assia L. , Varadinova Tatiana L.
Published: March 2007

Complexes of zinc with picolinic and aspartic acids inhibit key steps of HSV‐1 replication affecting different virus‐specific targets. As was recently demonstrated by us, the pavine alkaloid (‐)‐thalimonine irreversibly inhibits HSV‐1 infection in cultured cells. The aim of the present study was the evaluation of the combined effect of zinc complexes and (‐)‐thalimonine on uninfected and HSV‐1 infected cells. The data obtained have shown that zinc complexes and the alkaloid exert decreased cytotoxicity (antagonistic effect) and significantly increased anti‐HSV‐1 activity (synergistic effect) when applied in dual chess‐board combinations as compared to the individual effects of compounds tested. These combinations are also effective against the infection caused by a resistant to acyclovir (ACV) HSV‐1 mutant and the effect has been
recognised as synergistic.
Interaction of Cis‐ and Trans‐RuCl 2(DMSO)4 With Human Serum Albumin
Authors: Trynda-Lemiesz Lilianna , Kozlowski Henryk , Katsaros Nikolas
Published: March 2007

The interaction between cis‐ and trans‐ RuCl2(DMSO)4 and human serum albumin have been investigated through UV‐Vis, circular dichroism, fluorescence spectroscopy and inductively couplet plasma atomic emission spectroscopy (ICP(AES)) method Albumin can specifically bind 1 mole of cis‐isomer and 2 moles of the trans‐isomer RuCl2(DMSO)4 complex. The interaction of RuCl2(DMSO)4 with HSA causes: a conformational change with the loss of helical stability of protein; the strong quenching of the Trp 214 fluorescence indicating that the conformational change of the hydrophobic binding pocked in subdomain IIA takes place; a local perturbation of the warfarin binding site and induce some conformational changes at neighbour domains, a changing of the binding abilities towards heme.
Reaction of cis‐ and trans‐Dichlorotetra(Dimethylsulfoxide)Ruthenium(II) With the Antiviral Drug Acyclovir
Authors: Koutsodimou Aglaia , Natile Giovanni
Published: March 2007

NMR was used to investigate the reaction of cis‐ and trans‐[RuCl2(DMSO)4] with the antiviral drug acyclovir, a guanine derivative containing the acyclic (2‐hydroxo) ethoxymethyl pendant linked to N(9). Studies were performed in aqueous solutions at ambient temperature and at 37 °C, and at various molar ratios. Both isomers yielded two compounds, a monoadduct and a bisadduct, the relative yields being dependent upon the metal to ligand concentration ratios. The products derived from the two Ru isomers displayed identical NMR spectra, suggesting that they have the same coordination environment, however the rate of formation of the monoadduct was higher in the case of the trans isomer than in the case of the cis isomer, while the rate of conversion of the monoadduct into the bisadduct appeared to be similar in both cases. As a consequence in the case of the trans isomer there is accumulation of monoadduct in the early stage of the reaction, whose concentration afterwards decreases with the progress of the reaction. As for platinum, also for ruthenium the preferred binding site is N(7) of the purine base, however, in the case of ruthenium a discrete amount of bisadduct is formed even in the presence of an excess of metallic substrate with respect to the acyclovir ligand; under similar conditions a platinum substrate would have given, nearly exclusively, the monoadduct.
Synthesis of (N,N′‐Bis(2‐Hydroxyethyl)Ethane‐1,2‐Diamine)Malonatoplatinum(II) and X‐Ray Crystal Structure of the Cis-R,S‐Isomer
Authors: Galanski M. , Berger M. , Keppler B. K.
Published: March 2007

Hydroxyethyl substituted amineplatinum(II) and (IV) complexes are an interesting class of platinum based antitumour compounds due to their uncoordinated hydroxy groups. These hydroxy groups could play an important role in the mode of action of such complexes with respect to their ability to act as donor or acceptor for hydrogen bonds. Moreover, their chemistry in solution is of interest because it was found that there is the possibility of an intramolecular attack to form ethanolatoamine chelated species which are responsible for very stable monoadducts with 5′‐GMP. Furthermore, there is the possibility of derivatisation at the OH site to form a new series of platinum compounds which may be used for a carrier mediated transport to tumour tissues. In this context a series of (N,N′‐bis(2‐hydroxyethyl)ethane‐l,2‐diamine)‐platinum(II) complexes has been synthesised. During purification of one of the platinum based compounds, it was possible to isolate (SP‐4‐3)‐R,S‐(N,N′‐bis(2‐hydroxyethyl)ethane‐l,2‐diamine)malonatoplatinum(ll) and to resolve the structure by single crystal structure analysis. Intra‐ and intermolecular hydrogen bonds have been found which may explain the spontaneous crystallisation of the cis-R,S isomer and the stabilisation of the boat conformation of the malonatoplatinum(II) six‐membered ring.
Li+ Influx and Binding, and Li+/Mg2+ Competition in Bovine Chromaffin Cell Suspensions as Studied by 7Li NMR and Fluorescence Spectroscopy
Authors: Fonseca Carla P. , Montezinho Liliana P. , Baltazar Graça , Layden Brian , Freitas Duarte M. , Geraldes Carlos F. G. C. , Castro M. Margarida C. A.
Published: March 2007

Li+ influx by bovine chromaffin cells, obtained from bovine adrenal medulla, was studied in intact cell suspensions using 7Li NMR spectroscopy with the shift reagent [Tm(HDOTP)]4-. The influx rate constants, ki, were determined in the absence and in the presence of two Na+ membrane transport inhibitors. The values obtained indicate that both voltage sensitive Na+ channels and (Na+/K+)‐ATPase play an important role in Li+ uptake by these cells. 7Li NMR T1 and T2 relaxation times for intracellular Li+ in bovine chromaffin cells provided a T1/T2 ratio of 305, showing that Li+ is highly, immobilized due to strong binding to intracellular structures. Using fluorescence spectroscopy and the Mg2+ fluorescent probe, furaptra, the free intracellular Mg2+ concentration in the bovine chromaffin cells incubated with 15 mM LiCl was found to increase by about mM after the intracellular Li+ concentration reached a steady state. Therefore, once inside the cell, Li+ is able to displace Mg2+ from its binding sites.
Development of Novel DNA Cleavage Systems Based on Copper Complexes. Synthesis and Characterisation of Cu(II) Complexes of Hydroxyflavones
Authors: el Amrani F. Ben-Allal , Perelló L. , Borrás J. , Torres L.
Published: March 2007

Copper(II) complexes of several hydroxyflavones were prepared and characterised through their physico‐chemical properties. The nuclease activity of three synthesised complexes is reported. These copper(II) complexes present more nuclease activity than the ligands and the copper(II) ion.
Pharmacological Effects of the Ruthenium Complex NAMI‐A Given Orally to CBA Mice With MCa Mammary Carcinoma
Authors: Zorzet Sonia , Sorc Alenka , Casarsa Claudia , Cocchietto Moreno , Sava Gianni
Published: March 2007

NAMI‐A, imidazolium trans‐imidazoledimethylsulfoxidetetrachlororuthenate, is a
ruthenium based compounds capable of inhibiting the growth of lung metastases of solid
tumours in a number of experimental conditions.The aim of this study was to investigate
the potential use of NAMI‐A by the oral route to treat lung metastases of MCa mammary carcinoma in the CBA mouse. treatment of mice, carrying intramuscular tumours in
advanced stage of growth, for 11 consecutive days caused a significant reduction of the
weight of lung metastases over the range of doses from 150 to 600 mg/kg/day. No sign of
toxicity was observed at the histological analysis in the gut epithelium or in the kidney
parenchyma, and NAMI‐A concentration in the kidney was more than 10‐fold lower than
after intraperitoneal treatments. NAMI‐A is thus active against metastases also by the oral
route, suggesting the use of this way to treat tumour bearing hosts for long periods.
Inhibitory Effects of Dimeric Copper(II) bis(o‐acetoxybenzoate) on Platelet‐neutrophil adhesion and Thrombosis
Authors: Shen Zhiqiang , Wu Lanou , Liu Weiping , Liu Jikai , Chen Zhihhe
Published: March 2007

Antithrombotic effect of the copper‐aspirin complex (dimeric copper(II) bis(o‐acetoxybenzoate)
was evaluated in the model of venous thrombosis; its effects on platelet‐neutrophil adhesion were
investigated by use of rosette assay. The results showed that the intragastrically administered copper‐aspirin
complex (5, 7, and 10 mg kg−1) dose‐dependently lowered the wet and dry thrombus weight; it
significantly decreased the binding of arachidonic acid‐activated platelets to neutrophils with an IC50 value of 41.5 μmol L−1. The results suggested that copper aspirinate inhibited platelet‐neutrophil adhesion
and resulted in a more potent antithrombotic activity.
Interaction of Ruthenium(II)‐dipyridophenazine Complexes with CT‐DNA: Effects of the Polythioether Ancillary Ligands
Authors: Santos Teresa M. , Madureira João , Goodfellow Brian J. , Drew Michael G. B. , de Jesus Júlio Pedrosa , Félix Vitor
Published: March 2007

The complexes [Ru([9]aneS3)(dppz)Cl]Cl 1 and [Ru([12]aneS4)(dppz)]Cl2,2 ([9]aneS3 = 1,4,7‐
trithiaciclononane and [12]aneS4 = 1,4,7,10‐tetrathiaciclododecane) were synthesised and fully characterised .
These complexes belong to a small family of dipyridophenazine complexes with non‐polypyridyl ancillary
ligands . Interaction studies of these complexes with CT‐DNA (UV/Vis titrations, steady‐state emission and
thermal denaturation) revealed their high affinity for DNA . Intercalation constants determined by UV/Vis
titrations are of the same order of magnitude (106) as other dppz metallointercalators, namely
[Ru(II)(bpy)2dppz]S2+. Differences between l and2 were identified by steady‐state emission and thermal
denaturation studies . Emission results are in accordance with structural data, which indicate how geometric
distortions and different donor and/or acceptor ligand abilities affect luminescence . The possibility of noncovalent
interactions between ancillary ligands and nucleobases by van der Waals contacts and H‐bridges is
discussed . Furthermore, complex l undergoes aquation under intra‐cellular conditions and an equilibrium
with the aquated form l′ is attained . This behaviour may increase the diversity of available interaction
modes.
Transition Metal Ion Complexes of Schiff‐bases. Synthesis, Characterization and Antibacterial Properties
Authors: Chohan Zahid H. , Munawar Asifa , Supuran Claudiu T.
Published: March 2007

Some novel transition metal [Co(II), Cu(II), Ni(II) and Zn(II)] complexes of substituted pyridine Schiff‐bases
have been prepared and characterized by physical, spectral and analytical data. The synthesized Schiff‐bases
act as deprotonated tridentate for the complexation reaction with Co(II), Ni(II) and Zn(II) ions. The new
compounds, possessing the general formula [M(L) 2] where [M=Co(II), Cu(II), Ni(II) and Zn(II) and HL=HL1, HL2, HL3 and HL4] show an octahedral geometry. In order to evaluate the effect of metal ions upon
chelation, the Schiff bases and their complexes have been screened for antibacterial activity against the
strains such as Escherichia coli,Staphylococcus aureus, and Pseudomonas aeruginosa. The complexed
Schiff bases have shown to be more antibacterial against one more bacterial species as compared to
uncomplexed Schiff‐bases.
Copper (II) Acylhydrazinates. Their Synthesis and Characterization
Authors: Chohan Zahid H. , Farooq M. A. , Supuran Claudiu T.
Published: March 2007

Acylhydrazine derived furanyl and thienyl Schiff bases and their Cu(II) complexes have been prepared and
characterized on the basis of their physical, spectral and analytical data. The preferred enolic form of the
Schiff base function as a tetradentate ligand during coordination to the metal ion yielding a square planar
complex. The Schiff bases and their complexes with different anions were tested for their antibacterial
activity against bacterial species such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa
andKlebsiella pneumonae.
Enhanced Antioxidant Activities of Metal Conjugates of Curcumin Derivatives
Authors: Dutta Sabari , Murugkar Anupa , Gandhe Nitasha , Padhye Subhash
Published: March 2007

Antioxidant properties of three Curcumin derivatives in which the 1,3‐diketone system is
appended with nitrogen and sulfur donors and their copper conjugates are examined for the first time. Metal
conjugation seems to offer distinct advantages in radical scavenging activities of curcumin compounds.
Synthesis, Characterization and Antiproliferative Activity of the Co(II), Ni(II), Cu(II), Pd(II) and Pt(II) Complexes of 2‐(4‐Thiazolyl)Benzimidazole (Thiabendazole)
Authors: Wisniewski Marek Z. , Glowiak Tadeusz , Opolski Adam , Wietrzyk Joanna
Published: March 2007

Complexes of 2‐(4‐thiazolyi)benzimidazole (thiabendazole, THBD) with Co(II), Ni(II), Cu(ll) of
general formula ML2(NO3)2 H2O and complexes of Pd(II) and Pt(II) of general formula ML2Cl2 H2O have
been obtained and characterized by elemental analyses, IR and far IR spectroscopy and magnetic
measurements. The X‐ray crystal structure of the copper(II) complex has been determined. The in vitro cell
proliferation inhibitory activity of these compounds was examined against human cancer cell lines A 549
(lung carcinoma), HCV‐29 T (urinary bladder carcinoma), MCF‐7 (breast cancer), T47D (breast cancer),
MES‐SA (uterine carcinoma) and HL‐60 (promyelocytic leukemia). Pt‐THBD has been found to exhibit an
antileukemic activity of the HL‐60 line cells matching that of an arbitrary criterion.
Knigth′s Move in the Periodic Table, From Copper to Platinum,Novel Antitumor Mixed Chelate Copper Compounds, Casiopeinas,Evaluated by an in Vitro Human and Murine Cancer Cell Line Panel
Authors: Gracia-Mora Isabel , Ruiz-Ramírez Lena , Gómez-Ruiz Celedonio , Tinoco-Méndez Mabel , Márquez-Quiñones Adriana , Lira Laura Romero-De , Marín-Hernández Álvaro , Macías-Rosales Lucía , Bravo-Gómez Ma. Elena
Published: March 2007

We synthesized a novel anticancer agents based on mixed chelate copper (II) complexes, named
Casiopeínas® has of general formula [Cu(N‐N)(N‐O)H2O]NO3 (where, N‐N = diimines as 1,10‐
phenanthroline, 2,2‐bipyridine, or substituted and N‐O=aminoeidate or [Cu(N‐N)(O‐O)H2O]NO3 (where NN=
diimines as 10‐phenanthroline, 2,2‐bipyridine or substituted Casiopeínas I, II, IV, V, VI, VII VIII and
O‐O=acetylacetonate, salicylaldehidate Casiopínas III). We evaluated the in vitro antitumor activity using
a human cancer cell panel and some nurine cancer cells. Eleven Casiopeinas are evaluated in order to
acquire some structure‐activity correlations and some monodentated Casiopeinäs analogues; cisplatinum
was used as control drug. The 50% growth inhibition observed is, in all cases reach with concentrations of
Casiopeina′s 10 or 100 times lower than cisplatinum. In a previous work we reported the induction of
apoptosis by Casiopeina II. The results indicate that Casiopeinass are a promising new anticancer drug
candidates to be developed further toward clinical trials.
Cytotoxicity of Co(III) Complexes of Arginine
Authors: Genova Petia , Varadinova Tatiana , Alexandrova Radostina , Trifunovic Sreco , Radivojsa Petar
Published: March 2007

The cytotoxicity of four Co(III) complexes of arginine on nontumour MDBK cells and on two cell lines
derived from transplantable tumors, LSCC‐SF(Mc29) and LSR‐SF (SR), was evaluated comparative!y. Based on the
cytotoxic concentration required to inhibit cell surveillance by 50% (CC50)
it was found that: (i) the cytotoxicity of
complexes tested increases when the concentration decreased; (ii) the cell surveillance depends on both complex and
cell specificities. The complex specificity was illustrated by the order 1 > 4 > 2 ≥ 3 . The cell specific response was
demonstrated by the fact that LSCC‐SG (Mc29) cells were up to 60 times more sensitive to 1 while LSR‐SF (SR)
cells were up to 1000 times more sensitive to 2 as compared to MDBK cells. Furthermore, with the prolongation of
action on nontumour cells the cytotoxicity of 4 decreased up to 300 times while for both tumour cells it was
independent on the duration of action.
Radioprotective Activity and Synthesis of Siladithioacetals and Germadithioacetals Derived from N‐substituted Naphthylethylimidazoline
Authors: Célariès Benoît , Rima Ghassoub , Court Louis , Lion Claude , Laval Jean-Denis
Published: March 2007

A number of organosilicon and organogermanium derivatives and some related compounds
including the N‐substituted. 2‐[1‐naphthylmethyl]‐2‐imidazoline and 2‐[1‐(1‐naphthyl)ethyl]‐2‐imidazoline
have been prepared and the toxicity of some compounds have been determined in mice. In this paper we
report the synthesis and the evaluation of the pharmacological activity of new organosilicon and
organogermanium, compounds such as sila‐ and germadithioacetals derived from N‐substituted
naphthylimidazolne.
Oligonucleotides Modified With Transplatin Derivatives: Fast and Efficient Metalloribozymes
Authors: Dalbiès-Tran Rozenn , Leng Marc , Boudvillain Marc
Published: March 2007

When an oligonucleotide containing a 1,3‐(G,G)‐transplatin cross‐link at a GNG site (N represents a
C, T, A or U residue) is paired with its complementary strand, the intrastrand adduct rearranges into an
interstrand cross‐link, resulting in the covalent attachment of both strands. Here, we have studied
the influence of the inert ligands of the platinum(II) complex and of the nucleotide residues in the vicinity of
the adduct on the rearrangement reaction. Dramatic effects on the linkage isomerization rate could be
37℃. The results are analyzed in relation with the mechanism of rearrangement of the 1,3‐intrastrand adducts into
interstrand cross‐links. The relevance of platinated oligonucleotides as potent and specific drugs is discussed.
Guanine Oxidation in Double‐stranded DNA by MnTMPyP/KHSO5: At Least Three Independent Reaction Pathways
Authors: Lapi Andrea , Pratviel Geneviève , Meunier Bernard
Published: March 2007

In order to better define the mechanism and the products of guanine oxidation within DNA, we investigated
the details of the mechanism of guanine oxidation by a metalloporphyrin, Mn‐TMPyP, associated to
KHSO5
on oligonucleotides. We found that the three major products of guanine oxidation are formed by
independent reaction routes. The oxidized guanidinohydantoin (1) and the proposed spiro compound 3 derivatives are not precursors of imidazolone lesion (Iz). These guanine lesions as well as their degradation products, may account for non‐detected guanine oxidation products on oxidatively damaged DNA.
Synthesis, Characterization and Antiviral Properties of Pd(II) Complexes With Penciclovir
Authors: Garoufis A. , Karidi K. , Hadjiliadis N. , Kasselouri S. , Kobe J. , Balzarini J. , De Clercq E.
Published: March 2007

With the aim to improve and extend the antiviral activity of the antiherpic drug penciclovir, to a
wider spectrum of viruses, we have synthesized and characterized new binary and ternary complexes of
Pd(II) of formulae cis‐(pen) 2PdCl2 and cis,[(nucl) 2Pd(pen) 2]Cl2, where nucl = guanosine, inosine,
cytidine or penciclovir. The characterization was mainly based on IR and  1H NMR spectroscopy, and
the results showed that in all prepared complexes, penciclovir coordinates to the metal through N7. The
far‐i.r. spectrum of the complex cis‐(pen) 2PdCl2 confirmed the cis‐ geometry around Pd(II). All the
prepared complexes were markedly active against HSV‐1 and HSV‐2 strains, but not against thymidine
kinase‐deficient HSV‐1 strains.
Studies on Some New Ru(III) Complexes Using aryl‐azo Pentane‐2,4‐dione and 2,6‐bis (2′‐Benzimidazolyl) Pyridine as Ligands:Synthesis, Spectroscopic, Luminescent, Electrochemical and Biological Activities
Authors: Mishra Lallan , Yadaw Ajay K. , Phadke Ratna S. , Choi Chang S. , Araki Koji
Published: March 2007

Some ruthenium(III) complexes with aryl‐azo 2,4‐pentanedione as co‐ligands (L 1H‐L 3H) have
been synthesized and characterized spectroscopically IR,  1H NMR, UV/Vis, ESR, conductimetric)
along with elemental analysis and FAB‐mass data. Their luminescent and redox properties have
been studied. The antibacterial, anti‐HIV and antitmnour activities have also been reported.
Cytotoxicity of Triorganophosphinegold(I) Complexes of Thiobenzoate
Authors: Vincent Beverly R. , Clarke David J. , Smyth Douglas R. , de Vos Dick , Tiekink Edward R. T.
Published: March 2007

The preparation and characterization of two triorganophosphinegold(I) complexes containing the anion
derived from thiobenzoic acid are described. The cytotoxicity of these complexes has been
investigated along with that of triphenylphosphinegold(I) mercaptopurinate, a known anti‐tumor
compound, against a variety of human cell lines. The complexes showed moderate to high cytotoxicity
(ID50 250 – 2500 ng/ml).
Synthesis of Silicon and Germanium Containing Heteroaromatic Sulfides as Cholesterol Level Lowering and Vasodilating Agents
Authors: Rubina Kira , Abele Edgars , Arsenyan Pavel , Abele Ramona , Veveris Maris , Lukevics Edmunds
Published: March 2007

Silicon and germanium containing heteroaromatic sulfides have been prepared using
phase transfer catalytic (PTC) system thiol / Si or Ge containing alkyl halide / solid KOH / 18‐
crown‐6 / toluene. The target sulfides were isolated in yields up to 92 %. It has been found that 2‐{[dimethyl (β‐triethylgermylethyl)‐silylmethyl]thio}‐1‐methylimidazole and 2‐{[dimethyl(β‐triphenylsilylethyl)
silyl‐methyl]thio}benzothiazole are the most active cholesterol level lowering and
vasodilating agents.
Novel Unsymmetrical Ru(III) and Mixed‐valence Ru(III)/Ru(II)Dinuclear Compounds Related to the Antimetastatic Ru(III) Drug NAMI‐A
Authors: Serli B. , Iengo E. , Gianferrara T. , Zangrando E. , Alessio E.
Published: March 2007

In this paper we report the stepwise preparation and the characterization of new unsymmetrical monoanionic
Ru(III) dinuclear compounds, [NH4][{trans‐RuCl4(Me2SO‐S)}(μ‐L){mer‐RuCl3(Me2SO‐S)(Me2SO‐O)}] (L = pyz (1), pym (2)). By a similar synthetic approach we also prepared new mixed‐valence Ru(III)/Ru(II)
dinuclear compounds of formula [NH4][{trans‐RuCl4(Me2SO‐S)}(μ‐pyz){cis,cis,cis‐RuCl2(Me2SO‐S) 2(CO)}] (L = pyrazine (pyz, 3), pyrimidine (pym, 4)). Moreover, we describe the chemical behavior of compounds 1-4 in physiological solution, also after complete reduction (with ascorbic acid) to the corresponding Ru(II)/Ru(II) species. Overall, the chemical behavior of 1 and 2 after reduction resembles that of the corresponding dianionic and neutral dinuclear species, [{trans‐RuCl3(Me2SO‐S)}2(μ‐L)] 2−
and [{mer‐RuCl3(Me2SO‐S)(Me2SO‐O)} 2 (μ‐L)]. On the other hand, the mixed‐valence dinuclear compounds 3 and 4,
owing to the great inertness of the cis,cis,cis‐RuCl2(Me2SO‐S) 2(CO)(1/2μ‐L) fragment, behave substantially
like the mononuclear species [trans‐RuCl4(Me2SO‐S)(L)] − in which the terminally bonded L ligand can be
considered as bearing a bulky substituent on the other N atom.
Antibacterial Co(II), Cu(II), Ni(II) and Zn(II) Complexes of Thiadiazoles Schiff Bases
Authors: Chohan Zahid H. , Jaffery Maimoon F. , Supuran Claudiu T.
Published: March 2007

Schiff bases were obtained by condensation of 2‐amino‐l,3,4‐thiadiazole with 5‐substituted‐salicylaldehydes
which were further used to obtain complexes of the type [M(L) 2]Cl2, where M=Co(II), Cu(II), Ni(II) or Zn(II).
The new compounds described here have been characterized by physical, spectral and analytical data, and have
been screened for antibacterial activity against several bacterial strains such as Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. The antibacterial potency of these Schiff bases increased upon chelation/complexation, against the tested bacterial species, opening new aproaches in the fight against antibiotic resistant strains.
Bio‐Inorganic Studies on the Fe(II) Sparfloxacin Complex
Authors: Jain Swati , Jain N. K. , Pitre K. S.
Published: March 2007

The qualitative and quantitative analysis of an antibiotic drug, 5‐amino‐1 cyclopropyl‐7 (cis‐3, 5
dimethyl‐1‐piperazyl)‐6,8‐ dihydro‐1, 4 dihydro‐4‐oxo‐3‐quinoline carboxylic acid (Sparfloxacin, SFX) and
its pharmaceutical formulation i.e.sparx‐100 tablet, has been done using polarographic and amperometric
methods. Complexation behavior of SFX with Fe(II), both in solid and liquid phases has been studied by
elemental analysis, IR.‐spectra and polarographic and amperometric methods. SFX produces a single
cathodic reduction wave in 0.1 M ammonium tartrate (supporting electrolyte) at pH 6.0 ±0.1. The wave is
diffusion controlled and wave height is proportional to the concentration of SFX. The complex is also
reversibly reduced at the electrode surface with diffusion‐controlled kinetics. The stoichiometry of the Fe(II)‐
SFX complex is 1:1. Antibacterial studies on the drug and its metal complex have been performed against
different bacteria. The observed results revealed the complex to be more potent in its antibacterial activity as
compared to the parent drug. On the basis of observed results it could be concluded that the prepared Fe(II)‐
SFX complex may be recommended to the therapeutic experts for its possible use as a more potent antibiotic
drug.