bluuebunny/crossref_metadata_2025 huggingface dataset:
Hepatitis E virus infection in the United States: Seroprevalence, risk factors and the influence of immunological assays
Authors: Pisano María Belén , Campbell Christopher , Anugwom Chimaobi , Ré Viviana Elizabeth , Debes José D.
Published: August 2022

In the United States (U.S.), a hepatitis E virus (HEV) seroprevalence between 6 and 21% has been described, with a decreasing trend. We aimed to investigate HEV infection in the U.S. population from 2009 to 2016, and examine the differences in seroprevalence using different assays. We used data from the National Health and Nutrition Examination Survey (NHANES-CDC) to estimate HEV seroprevalence and analyze demographic variables related to the infection. Additionally, we compared 4 serological tests used. The estimated HEV seroprevalence between 2009–2016 was 6.1% (95% CI: 5.6%-7.0%) for IgG and 1.02% (0.8%-1.2%) for IgM. Higher HEV IgG prevalences were found in older people, females, non-Hispanic Asians and those born outside of the U.S. The in-house immunoassay and the Wantai HEV-IgG ELISA presented the highest sensitivity values in the tested population. The highest specificity values corresponded to the DSI-EIA-ANTI-HEV-IgG assay. The kappa statistical values showed concordances no greater than 0.64 between the assays. HEV prevalence in our study was similar to previously reported, and a decline in the prevalence was observed through the NHANES assessments (from 1988 to 2016). The sensitivity and specificity of the assays varied widely, making comparisons difficult and highlighting the need to develop a gold standard assay.
Influenza A virus elicits peri-vascular adipose tissue inflammation and vascular dysfunction of the aorta in pregnant mice
Authors: Oseghale Osezua , Liong Stella , Coward-Smith Madison , To Eunice E. , Erlich Jonathan R. , Luong Raymond , Liong Felicia , Miles Mark , Norouzi Shaghayegh , Martin Cara , O’Toole Sharon , Brooks Robert D. , Bozinovski Steven , Vlahos Ross , O’Leary John J. , Brooks Doug A. , Selemidis Stavros
Published: August 2022

Influenza A virus (IAV) infection during pregnancy initiates significant aortic endothelial and vascular smooth muscle dysfunction, with inflammation and T cell activation, but the details of the mechanism are yet to be clearly defined. Here we demonstrate that IAV disseminates preferentially into the perivascular adipose tissue (PVAT) of the aorta in mice. IAV mRNA levels in the PVAT increased at 1–3 days post infection (d.p.i) with the levels being ~4–8 fold higher compared with the vessel wall. IAV infection also increased Ly6Clowpatrolling monocytes and Ly6Chighpro-inflammatory monocytes in the vessel wall at 3 d.p.i., which was then followed by a greater homing of these monocytes into the PVAT at 6 d.p.i. The vascular immune phenotype was characteristic of a “vascular storm”- like response, with increases in neutrophils, pro-inflammatory cytokines and oxidative stress markers in the PVAT and arterial wall, which was associated with an impairment in endothelium-dependent relaxation to acetylcholine. IAV also triggered a PVAT compartmentalised elevation in CD4+and CD8+activated T cells. In conclusion, the PVAT of the aorta is a niche that supports IAV dissemination and a site for perpetuating a profound innate inflammatory and adaptive T cell response. The manifestation of this inflammatory response in the PVAT following IAV infection may be central to the genesis of cardiovascular complications arising during pregnancy.
Remuneração médica e qualidade da assistência à saúde
Authors: Porto Flavia Maciel , Carnut Leonardo
Published: August 2022

Revisar o que a literatura apresenta sobre a relação entre remuneração médica e qualidade da assistência à saúde tentando elucidar as formas de mensuração de desempenho subjacentes a esta relação. Foi realizada uma revisão integrativa no portal da Biblioteca Virtual de Saúde (BVS). A estratégia de busca foi construída pelos polos: remuneração (fenômeno); médicos (população); e qualidade da assistência (contexto). Português, espanhol e inglês foram o limite de idioma. Dois revisores selecionaram as publicações via fluxograma PRISMA. A análise foi feita na modalidade narrativo-cronológica. 35 artigos foram incluídos. Dos artigos, extraiu-se: autores, ano, método, país, objetivo; e sintetizou-se: as principais conclusões, o tipo de remuneração médica, a forma de mensuração do desempenho e os indicadores de qualidade da assistência. Há 3 fases no desenvolvimento do tema: de 1994–2000 (comparação-transição nas formas de remuneração); de 2001–2010 (qualidade e conflito desempenho versus equidade) e de 2011–2020 (desempenho como modulador do comportamento médico). Conclui-se que o tema é escasso, com baixo nível de evidência científica disponível (nível 4 e 5). De acordo com os estudos na base de dados revisada, não é possível afirmar que o pagamento por desempenho melhora a qualidade dos cuidados por inúmeros fatores. Efeitos indesejáveis da remuneração por desempenho podem aumentar a inequidade ao longo do tempo. Sugere-se que estudos possam usar outras metodologias para verificar melhor se existe esta relação de causalidade.
Calidad de la alimentación y estrategias de aculturación alimentaria en migrantes colombianos residentes en Chile
Authors: Hun Gamboa Nelson , Urzúa Afonso , Leiva José , López-Espinoza Antonio
Published: August 2022

Introducción: La migración ha sido asociada a un mayor consumo de alimentos de alta densidad energética y aumento de peso. El objetivo de este estudio fue analizar la relación entre la calidad global de la alimentación y estrategias de aculturación alimentarias en migrantes colombianos residentes en Chile
Métodos: Estudio no experimental, descriptivo y correlacional. La muestra total estuvo compuesta de 258 migrantes colombianos residentes en Chile. Se realizaron tablas cruzadas y pruebas de diferencias de medias.
Resultados: Mujeres tuvieron una mayor calidad de la alimentación cuando utilizaron las estrategias de aculturación alimentaria de separación y evitación. Hombres tuvieron mayor puntaje con evitación e integración. La mayor calidad de la alimentación en mujeres se dio después de 5 años post migración, hombres entre los 6 meses y 1 año.
Conclusión: Mujeres y hombres poseen diferentes mecanismos de adaptación o desadaptación alimentaria post migración, a excepción de la evitación alimentaria. Del mismo modo un mayor tiempo de residencia favorece la calidad de la alimentación en mujeres, no así, en hombres. Es necesario seguir indagando el efecto de otras variables y otros colectivos migrantes.
Obstacles to Environmental Progress: A U.S. perspective
Authors: Schulze Peter
Published: August 2022

Why, when so many people understand the severity of environmental problems, is progress so slow and sustainability such a distant goal? What gets in the way? Perhaps you have immediately thought of several barriers. In Obstacles to Environmental Progress, Peter Schulze identifies 18 practical obstacles that routinely and predictably hinder U.S. progress on existing environmental problems. The obstacles apply to problems small and large and, in most cases, regardless of whether an issue is controversial. Though the book focuses on the U.S., most of the obstacles pertain elsewhere as well. The obstacles fall into three categories: scientific challenges to anticipating and detecting problems; political and economic factors that interfere with responding; and obstacles to effective responses. While all the obstacles are predictable and common, they have not been systematically studied as related phenomena, perhaps because they span a wide range of academic disciplines. In practice, they often arise as surprises that are then addressed in an ad hoc manner. Might they be better understood and thus more readily anticipated and overcome or avoided? The book seeks to hasten environmental progress by forewarning and thus forearming those who are striving or will soon be striving for environmental progress, and by drawing scholarly attention to the obstacles as a set of related phenomena to systematically understand and more quickly overcome
Língua(gem), discurso e ensino
Authors: Figueira-Borges Guilherme , Bonvino Stafuzza Grenissa , Alves Fernandes Cleudemar
Published: August 2022

Texto de apresentação e reflexão norteadora para o número temário "Língua(gem), discurso e ensino", v. 4, n. 1, da revista Heterotópica.
The Effect of Intellectual Capital and Innovative Work Behavior on Business Performance
Authors: Almaududi Ausat Abu Muna , Widayani Anna , Rachmawati Ika , Latifah Nunuk , Suherlan Suherlan
Published: August 2022

The twenty-first century is a century of knowledge, discovery, and innovation, with rapid advances in science and information technology marking significant developments. The level of competitiveness within organizations is increasing. This truth motivates entrepreneurs to grow in order for their businesses to thrive. The major goal of this research is to examine how intellectual capital and innovative work behavior affect business performance in SMEs. The author then explains the three constructions' conceptual structure. To further understand the relationship between variables, quantitative methods based on Structural Equation Modeling (SEM) and Partial Least Squares (PLS) variance were used. Participants were chosen from SMEs in Yogyakarta, Indonesia, via an online questionnaire. The findings of this research show that intellectual capital and creative work behavior have a positive and significant effect on business performance. SMEs can use intellectual capital to define expected performance and as a tool to evaluate performance to develop employees who will be able to meet the needs of SMEs in the future. Furthermore, it demonstrates that SMEs, not just large corporations, can attain high-performance levels throughÂ synchronizing intellectual capital and innovative work behavior.
Percutaneous Intervention With GuideLiner Catheter in 4 Patients With Anomalous Coronary Artery Originating From Opposite Sinus of Valsalva
Authors: Unzué Leire , Barrio Patricia , García Eulogio , Mestre Rodrigo Teijeiro , Rodríguez Rodrigo Francisco José , Parra Francisco Javier
Published: August 2022

Percutaneous intervention in anomalous coronary arteries originating from the opposite sinus of Valsalva is complicated by their unusual location and course, which makes selective cannulation difficult. The GuideLiner (Vascular Solutions, Inc.) is a monorail guide extension catheter designed to advance beyond the tip of a mother guide catheter to enable deep intubation of a coronary artery, provide extra support, and improve coaxial alignment. We describe the cases of 4 patients with an anomalous coronary artery originating from the opposite sinus of Valsalva—including 2 with acute myocardial infarction—who underwent successful percutaneous coronary intervention with use of a GuideLiner catheter.
Modulation of blood pressure regulatory genes in the Agtrap‐Plod1 locus associated with a deletion in Clcn6
Authors: Klemens Christine A. , Dissanayake Lashodya V. , Levchenko Vladislav , Zietara Adrian , Palygin Oleg , Staruschenko Alexander
Published: August 2022

The AGTRAP‐PLOD1 locus is a conserved gene cluster containing several blood pressure regulatory genes, including CLCN6, MTHFR, NPPA, and NPPB. Previous work revealed that knockout of Clcn6 on the Dahl Salt‐Sensitive (SS) rat background (SS‐Clcn6) resulted in lower diastolic blood pressure compared to SS‐WT rats. Additionally, a recent study found sickle cell anemia patients with mutations in CLCN6 had improved survival and reduced stroke risk. We investigated whether loss of Clcn6 would delay the mortality of Dahl SS rats on an 8% NaCl (HS) diet. No significant difference in survival was found. The ability of Clcn6 to affect mRNA expression of nearby Mthfr, Nppa, and Nppb genes was also tested. On normal salt (0.4% NaCl, NS) diets, renal Mthfr mRNA and protein expression were significantly increased in the SS‐Clcn6 rats. MTHFR reduces homocysteine to methionine, but no differences in circulating homocysteine levels were detected. Nppa mRNA levels in cardiac tissue from SS‐Clcn6 rat in both normotensive and hypertensive conditions were significantly reduced compared to SS‐WT. Nppb mRNA expression in SS‐Clcn6 rats on a NS diet was also substantially decreased. Heightened Mthfr expression would be predicted to be protective; however, diminished Nppa and Nppb expression could be deleterious and by preventing or blunting vasodilation, natriuresis, and diuresis that ought to normally occur to offset blood pressure increases. The conserved nature of this genetic locus in humans and rats suggests more studies are warranted to understand how mutations in and around these genes may be influencing the expression of their neighbors.
Neuroprotective and metabotropic effect of aerobic exercise training in female patients with type 2 diabetes mellitus
Authors: Cokar Dilek , Polat Mine Gulden , Timurtas Eren , Sertbas Yasar , Sogut İbrahim
Published: August 2022

Objectives

We aimed to evaluate the effects of acute and chronic aerobic exercise on cognitive function and depression levels in patients with Type 2 Diabetes Mellitus (T2DM) and the changes in related neurotrophic and metabotropic factors.

Methods

Sixteen female patients (age=57.5 ± 7.3) diagnosed with T2DM were included. A and B sections of the Trail Making Test (TMT) and Beck Depression Inventory (BDI) were used to assess executive function and depression states. Brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), irisin, total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), fasting plasma glucose, hemoglobin A1c, and high-density lipoprotein (HDL) cholesterol were analyzed in blood. Aerobic exercise intensity was applied at 50–70% of the maximal heart rate for 40 min/day, three days weekly on the treadmill. All evaluations were repeated after one exercise session, a 12-week exercise program, and after one year for follow-up.

Results

TMT-A (p=0.001) and TMT-B (p=0.002) values were increased following both acute and chronic exercise. BDI scores were decreased after long-term exercise (p=0.031). Measurement of metabolic parameters revealed positive changes in HDL cholesterol (p=0.044), TAS (p=0.005), and OSI (p=0.009) values ​​after chronic period exercise. No significant difference was found in BDNF (p=0.271), NGF (p=0.230), and irisin (p=0.101) values ​​after acute or chronic exercise, on the other hand.

Conclusions

Although aerobic exercise training had a positive effect on metabolic and cognitive outcomes, this effect was independent of neurotrophic and metabotropic factors. Regular and long-term aerobic exercise training has protective and regulatory functions in T2DM.
ARFs get the BioID treatment: what have we been missing?
Authors: Barneda David , Stephens Len , Hawkins Phillip
Published: August 2022

Li et al present the results of a proximity‐interaction screen in mammalian cells for the effector proteins of 25 members of the Arf family of small GTPases. This study has generated an important resource for those working in several areas of cell biology and provided an initial characterisation of two new cellular roles for some of the least well studied members of this family, the regulation of PLD1 by ARL11/14 in phagocytosis, and the regulation of PI4KB by ARL5A/5B in the Golgi.
Antibacterial Activity of N-hexane and Diethyl Ether Fraction of Piper betle L. Leaf Against Staphylococcus aureus dan Escherichia coli Bacteria
Authors: Kunti Mulangsri Dewi Andini , Ningrum Ria Ayu , Imliyyah Nafilatul
Published: August 2022

Escherichia coli and Staphylococcus aureus bacteria are still cause of superficial and systemic infections. Fractionation of green betel leaf extract was carried out to obtain simpler compounds than the crude extract. The purpose of this study was to determine the antibacterial activity of the n-hexane fraction and the diethyl ether fraction of green betel leaf against Escherichia coli and Staphylococcus aureus. The extract of green betel leaf was fractionated with n-hexane and diethyl ether. The n-hexane fraction (HF) and diethyl ether fraction (DF) were tested for antibacterial activity using the disc diffusion method and the concentrations used were 0.5; 1; 1.5; 2; and 2.5 mg/disc. Chloramphenicol paper disc 30 µg/disk as a positive control and DMSO as a negative control. Data analysis was carried out descriptively by observing the inhibition zone around the paper disc which indicated the presence of antibacterial activity. The inhibition zone has measured the diameter of the inhibition area. The test results showed that there was antibacterial activity in the HF and DF of green betel leaf against Escherichia coli and Staphylococcus aureus bacteria, indicated by the presence of an inhibitory zone around the paper disc at all concentrations. The average diameter of the inhibition area produced against Escherichia coli and Staphylococcus aureus were 10.89–12.58 mm and 7.28-11.93 mm for green betel of HF and6.51–11.89 mm and 8.43–15.18 mm for green betel of DF, respectively
Separation of Cerium, Neodymium, and Lanthanum from Rare Metal Concentrates by Calcining and Leaching Using Hydrochloric Acid
Authors: Alfawwazi Abdul Fattah , Setyadji Much. , Jumaeri Jumaeri
Published: August 2022

The separation of Ce, La, and Nd elements from rare earth metal (REOH) concentrates from monazite sand processing needs to be done because the uses of La and Nd in the industry are very large. This research was conducted to determine the optimization of leaching in the separation of Ce, La, and Nd. The method used to separate the elements Ce, La, and Nd from the rare earth metal concentrate is through calcination at a temperature of 600°, 800°, 1000°C for 2 hours and without calcination, followed by a leaching process using 0.9 M HCl solvent at a temperature of 75°C. Variations made are the ratio of solid and liquid ratio and variations in time (5, 10, 15, 20, and 25 minutes), and the stirring speed is fixed at 150 rpm. From the results of FT-IR and XRD analysis, it is known that calcination can convert REOH concentrate into REO. Residual analysis of leaching results using XRF showed that the increase in calcination temperature with a solid and liquid ratio and leaching time could affect the leaching efficiency results. The highest leaching efficiency for the element La was obtained at a calcination temperature of 1000°C with a time of 10 minutes, which was 73.20%. Meanwhile, the optimum condition for the best leaching process for Nd is at a calcination temperature of 1000°C with a contact time of 5 minutes with a leaching efficiency of 49.68%.
Synthesis of The Tangerine-based Cdots and AgNp-Cdots Composite
Authors: Kristian Aprilia , Wahyuni Sri
Published: August 2022

Silver nanoparticles (AgNp) have been widely developed, one of which is an antibacterial agent. The ability of AgNp to inhibit bacteria is unquestionable. These properties and characteristics can be studied further by adding defects. The defect used is Cdots from tangerines. Cdots are new materials that can be synthesized from natural materials and have unique properties. AgNp itself was synthesized by the chemical reduction method with sodium citrate as a reducing agent, while Cdots was synthesized by hydrothermal method. The results of the synthesis were analyzed using the Fourier Transform Infrared (FT-IR) method. Absorption appears at a wave number of 1637 cm-1 which indicates the presence of C=C, C=O bonds which are characteristic of Cdots. For AgNp, absorption appears at a wave number of 593.11 cm-1 which indicates the presence of Ag vibrations. Analysis with UV-Vis spectrophotometer gave the results at a wavelength of 431 nm absorbance AgNp-Cdots of 0.723 and a wavelength of 422 nm AgNp absorbance of 0.285. The results of the Particle Size Analyzer (PSA) analysis showed that AgNp-Cdots had an average size of 38.7 nm with a PI of 0.499 and pure AgNp of 51.8 nm with a PI of 0.566. Antibacterial activity of AgNp-Cdots against E. coli bacteria showed an inhibition zone of 2 mm while AgNp showed an inhibition zone of 5 mm.
The The Effect of MRD (Milk of Red Rice and Dates) Composition on the Degradation Stability of Milk Dyes and The Content of Milk Microbial Contamination
Authors: Latifah Rais Nur
Published: August 2022

Milk is a nutritious drink that contains nutrients and vitamins needed by the body. In this study, a variant of the composition of red rice with Sukari dates and tested to obtain the best level of milk stability in the form of MRD. The composition of MRD was varied, namely MRD type I and MRD type II. The method used in this research is the analysis of milk dye degradation, milk stability analysis, microbial contamination analysis, and organoleptic testing. The results of the research on the degradation of milk dyes showed that both types of milk were in 2nd order with the reaction rate constant for type I MRD being 0.0582 and MRD type II was 0.0181. The level of stability of milk from MRD type I is 2nd order with a rate constant of 0.0953 and MRD type II is 1st order with a rate constant of 0.0998. For the microbial contamination assay showed that the microbial contamination test, showed that the two types of MRD, namely MRD type I and MRD type II were still within the safe limits and did not exceed the safe limits required by the SNI 7388:2009. The results of the hedonic test showed that the MRD type II was more favored by the respondents than the MRD type I.
Ethics, moral practices and age-related social issues in late 18th-century medical discourse
Authors: Lonati Elisabetta
Published: August 2022

The second half of the eighteenth-century is particularly interesting for the study of medicine, and medical practice. The professional role of physicians, their social function, and their moral duties necessarily became a key issue for the period under scrutiny, and for decades to come. Medical ethics and moral practices, as well as philanthropic attitudes, constituted a relevant topic in medical writing: John Gregory (1724–73; Edinburgh University) and Thomas Percival (1740–1804; Manchester Infirmary) were the pioneers of medical ethics ‘in the making’.

The aim of this study is to investigate the lexis of medical ethics and moral practices and its impact at textual and discourse levels. In other words, how the lexicalisation of values and principles shapes and frames the discourse on medical ethics, and on the social identity of target people-patients of all ages (old, young, middle-aged), as well as potentially age-related discriminatory practices between the 1770s and 1800s.
Multilingualism and Politics: Revisiting Multilingual Citizenship Edited by Katerina Strani (2020)
Authors: Sauer Bredvik Linda
Published: August 2022

Multilingualism and Politics: Revisiting Multilingual Citizenship Edited by Katerina Strani (2020) London: Palgrave Macmillan, 365 pp.
Impacts of reforestation on soil and soil organic carbon losses
Authors: Lense Guilherme Henrique Expedito , Parreiras Taya Cristo , Servidoni Lucas Emanuel , Mincato Ronaldo Luiz
Published: August 2022

ABSTRACT Water erosion is a serious environmental problem that causes soil degradation, compromises its fertility and causes soil organic carbon (SOC) losses. Reforestation, encouraged by Brazilian environmental legislation, is a way to reduce water erosion. However, in tropical and subtropical regions, there is little information on the impact of reforestation on soil loss rates and SOC. Therefore, this study aimed to apply the Erosion Potential Method, combined with multitemporal data from soil samples collected in situ, to estimate and spatialize soil and SOC losses in a predominantly agricultural Brazilian watershed that showed high rates of reforestation in the period studied from 2011 to 2019. The determination of the EPM parameters was carried out with the aid of a Geographic Information System and the soil loss estimate was validated with information from a hydrosedimentological collection station. The results showed that between 2011 and 2019 water erosion was reduced by 27.5%, while carbon losses were reduced by 32.7%. Among the evaluated crops, corn showed the highest soil and SOC losses, while coffee and forest areas exhibited the lowest rates. Reforestation of the basin is the main factor responsible for the reduction of soil losses. This process was initiated seeking to meet the requirements of the Brazilian Forest Code, which highlights the positive role that public policies can play in environmental conservation when respected and well applied.
CIRCUIT TRAINING REDUCES CARDIOMETABOLIC RISK FACTORS IN WOMEN
Authors: Zanina Gustavo Osório , Guillo Lídia Andreu , Prudente Paulo Adriano Naves , Alves Fagner Medeiros , Cruz Anderson Miguel da , Silva Maria Sebastiana
Published: August 2022

ABSTRACT Introduction Combined training is more effective than an isolated modality in reducing cardiometabolic risk indicators. Objective To evaluate the effect of circuit training volume on anthropometric and biochemical risk indicators for cardiometabolic diseases in overweight women. Methods Thirty-two participants underwent 24 weeks of circuit training with free weights combined with aerobic exercise. The training volume during the 24 weeks was used to distribute the women into moderate-volume physical activity (MVA), low-volume physical activity (LVA) and control (CON) groups. Anthropometric indices (body mass, body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR)), blood glucose, insulin, insulin resistance (HOMA-IR), total cholesterol (TC), triglycerides, HDL-c, and LDL-c were evaluated at the beginning of the program and after 12 and 24 weeks. Results There was no interaction between training volume and time for any of the variables studied, but the intervention time influenced body mass (p=0.013) and BMI (p=0.012), and there was a tendency for participation time to reduce body mass (p=0.063) and BMI (p=0.062) after six months of intervention. The volume of the physical activity affected HDL-c (p=0.037), being significant (p=0.030) in the comparison between the MVA and CON groups. Additionally, there was a downward trend in HDL-c after six months of intervention (p=0.073), with a smaller reduction observed in the MVA group, indicating a protective role of moderate physical activity in the reduction of this lipid fraction. The association between physical activity volume and participation time resulted in a clinical improvement in total cholesterol (χ2 = 5.453, p = 0.02), with a higher probability of reaching clinically adequate values in the MVA group (OR = 0.126; 95%CI 0.019 - 0.827). Conclusion Training volume improved cardiometabolic risk factors in overweight women. Level of evidence II; Therapeutic Studies - Investigating the Results of Treatment.
EFFECTS OF SLING EXERCISE ON THE CORE ENDURANCE AND PERFORMANCE OF BASKETBALL PLAYERS
Authors: Liu Qingguang , Zhu Chuanfang , Huang Qiangmin
Published: August 2022

ABSTRACT Introduction Strong core stability and strength enable the trunk to transfer the maximum amount of torque to the terminal segments, which is conducive to improving athletic performance. Because sling training is a new core exercise method, its effect on trunk endurance relative to basketball performance has rarely been studied. Objective To investigate whether a core exercise program in a specific sports group can improve core and sports-specific performance. Methods A total of 40 college students majoring in basketball were randomly assigned to training and control groups. A standardized set of core endurance and basketball-specific performance tests were used to determine and assess the effects of sling training on trunk strength, endurance, and control. Results Flexor, extensor, and right and left lateral trunk flexor muscles endurance were significantly greater in the training group than in the control group, and the time to complete the layup obstacle course was shorter than in the control group at the end of the training program, p<0.01. No differences between the two groups were found in the penalty shot, the fixed position shot, or the vertical jump and reach at the end of the training program. Conclusions Sling exercises can improve the core endurance and strength of basketball players and increase the speed of lay-ups over obstructions. Level of evidence I; Randomized clinical trial.
EVALUATION OF ANXIETY AND DEPRESSION SYMPTOMS AMONG U-20 SOCCER ATHLETES IN RECIFE-PE: A CROSS-SECTIONAL STUDY
Authors: Rodrigues André Furtado de Ayalla , Barbosa Leopoldo Nelson Fernandes , Gomes Paulo Cesar dos Santos , Nóbrega Filipe Albuquerque Fernandes
Published: August 2022

ABSTRACT Introduction Being a soccer player is one of the dreams most present in the popular imagination of Brazilian children. However, the path to professionalization is arduous and several reasons can be pointed out for this difficulty: a very competitive environment, few chances, and poor career counseling, among others. In competitive soccer, the athlete must be ready for all the demands that will be made, as well as accept the demand for the best possible performance. Furthermore, athletes from the youth system are still adolescents and youths in development, usually up to 21 years of age, who are often forced to choose soccer and its demands, at the expense of their studies and family lives, to become professional players. In this scenario, a still little-debated topic is mental health among soccer players. Objectives To verify the frequency of anxiety and depression symptoms among soccer players of the under-20 youth categories of Pernambuco clubs and to assess its association with sociodemographic, athletic, and health data. Methods The Hospital Anxiety and Depression Scale (HADS) was applied and socio-demographic, athletic, and health data were collected. A marginal descriptive analysis was conducted, as well as categorical and numerical assessments of anxiety- and depression-related variables. Finally, a linear regression study of the anxiety and depression scores was conducted. Results A statistically significant association was found between income received and an increase in anxiety symptoms. An increase in depressive symptoms as income decreased was also identified. Conclusion Further research with larger numbers of participants is needed, as well as with a greater variety of clubs, to better understand the relationship observed. Level of Evidence II; Prognostic study – Investigation of the effect of a patient characteristic on the outcome of their illness.
IMPACT OF MORPHOLOGICAL CHARACTERISTICS AND MOTOR SKILLS WHEN PERFORMING GYAKU TSUKI
Authors: Doder Dragan , Radišić Lana , Mujanović Rifat , Mojsilović Zoran
Published: August 2022

ABSTRACT Objective The aim of this study was to determine the influence of morphology on karate characteristics and basic motor skills for the criterion variable counter-punch (gyako zuki) in boys, after a two-year training program. Methods A system of 25 variables (12 morphological, 12 motor, and one situational (gyako zuki)) was applied in a sample of 82 karatists, aged 10 to 14 years. Data were processed using regression analysis. Results Body weight had a statistically significant influence on the criterion variable in the initial measurement, as well as on the triceps and back skinfolds in the final measurement. In the motor space, semi-squat endurance had a significant impact on both initial and final measurements. In the reduced system, triple jump, half-squat endurance, and long jump impacted the initial measurement, while the 30-second torso lift, hyperextension on the bench, and semi-squat endurance impacted the final measurement. Conclusion From the data obtained, it can be concluded that the counter-punch (gyako zuki) performance results were better in participants with higher body weight, longer arms, less subcutaneous upper arm and back fat, greater static and explosive power in the lower limbs, and greater hamstring and spine flexibility. Evidence Level II; Therapeutic Studies – Investigating the results.
Modeling of adult patient falls and the repercussions to Nursing as a second victim
Authors: Quadros Deise Vacario de , Magalhães Ana Maria Müller de , Wachs Priscila , Severo Isis Marques , Tavares Juliana Petri , Dal Pai Daiane
Published: August 2022

Abstract Objective: analyze the falls of adult hospitalized patients and their repercussions on the Nursing worker as the second victim. Method: an exploratory, descriptive and qualitative study conducted in two stages - identification of falls with moderate to severe damage and the modeling of falls using the software Functional Resonance Analysis Method; and analysis of the repercussions on the worker as the second victim by means of semi-structured interviews submitted to Content Analysis, with 21 Nursing workers. Results: a total of 447 falls of adult patients were identified, 12 of which with moderate to severe damage, occurred in the absence of the companion, while using sleep inducing, hypotensive or muscle strength altering medications. The modeling identified 22 functions related to the Standard Operating Procedure, to the fall prevention protocol and to the post-event actions. Of these, eight presented variability in their execution. In the second step, the categories “The complexity of care to prevent falls” and “Feelings of the second victim” emerged. Conclusion: falls are complex phenomena and prevention requires involvement of the patient, family and multi-professional team. The professionals involved are second victims and experience feelings of guilt, fear, anguish and helplessness. This study can contribute to the multi-professional spirit and to the early approach to second victims.
Modelaje de caídas de pacientes adultos y las repercusiones en la Enfermería como segunda víctima
Authors: Quadros Deise Vacario de , Magalhães Ana Maria Müller de , Wachs Priscila , Severo Isis Marques , Tavares Juliana Petri , Dal Pai Daiane
Published: August 2022

Resumen Objetivo: analizar las caídas de pacientes adultos hospitalizados y sus repercusiones en el trabajador de Enfermería como segunda víctima. Método: estudio exploratorio, descriptivo y cualitativo realizado en dos etapas - Identificación de las caídas con daño moderado a grave y el modelaje de las caídas utilizando el software Functional Resonance Analysis Method y Análisis de las repercusiones en el trabajador como segunda víctima por medio de entrevistas semiestructuradas posteriormente sometidas al Análisis de Contenido, en 21 trabajadores de Enfermería. Resultados: fueron identificadas 447 caídas de pacientes adultos, siendo 12 con daño moderado a grave, ocurridas en la ausencia del acompañante, al usar medicamentos inductores de sueño, hipotensores y/o los que alteran la fuerza muscular. El modelaje identificó 22 funciones relacionadas al Procedimiento Operacional Estándar, es decir el protocolo de prevención de caídas y las acciones seguidas después del evento. Entre estas, ocho presentaron variabilidad en su ejecución. En la segunda etapa, surgieron las categorías “La complejidad de los cuidados para prevenir las caídas” y “Sentimientos de la segunda víctima”. Conclusión: las caídas son fenómenos complejos y la prevención exige la participación del paciente, familia y equipo multiprofesional. Los profesionales involucrados son segundas víctimas y experimentan sentimientos de culpa, miedo, angustia e impotencia. Este estudio puede contribuir con la multiprofesionalidad y el abordaje precoz a las segundas víctimas.
Physical violence against women by their intimate partner during pregnancy and its relationship with breastfeeding
Authors: Aristizábal Liliana Yanet Gómez , Theme Filha Mariza Miranda
Published: August 2022

Abstract Objectives: to estimate the association between physical violence against women by their intimate partner during pregnancy and breastfeeding. Methods: the data source is the 2010 National Demographic and Health Survey (DHS) conducted in Colombia, and 11,416 mother-child dyads were analysed. The relationship between physical violence against women by their partner during pregnancy and breastfeeding indicators was carried out using the weighted propensity score from the Inverse Probability of Treatment Weighting (IPTW). Variables for adjustment were selected through the Directed Acyclic Diagram (DAG) and performed a sensitivity analysis to identify the strength of hidden bias. Results: according to the data, 6.4% (730) of the women suffered physical violence by their partner during their pregnancy. The median time of exclusive breastfeeding was 1.0 month. No statistically significant relationship was observed with any of the breastfeeding indicators analysed: exclusive breastfeeding (OR=1.17; CI95%=0.82-1.67); breastfeeding at any time (OR=1.61; CI95%=0.58-2.60); and initiation of breastfeeding (OR=1.07; CI95%=0.74-1.2) Conclusion: although the association between violence against women committed during pregnancy and breastfeeding indicators was not found, the suboptimal breastfeeding practices and high prevalence of violence against women by the partner are two major public health issues in Colombia. Prenatal care professionals can change this scenario by identifying women exposed to intimate partner violence and offering tailored support for breastfeeding practices.
Analysis of the structural adequacy of maternity hospitals in Piauí, Brazil, 2018-2019
Authors: Madeiro Alberto , Rufino Andréa Cronemberger , Nunes Maria das Dores Sousa , Martins Victor Manfrinni Magalhães Lima , Barbosa Clara Maria , Sousa Alessandra Maria Cerqueira de , Acaqui Raiza Farnochia
Published: August 2022

Abstract Objectives: to evaluate the structure and adequacy of maternal healthcare facilities in Piauí. Methods: cross-sectional study in 26 hospitals with more than 200 births/year between 2018-2019. The structure was assessed by direct observation and interview with manager, in four domains: physical aspects, human resources, equipment, and drugs. Fisher’s chi-square/exact tests were used to assess differences in adequacy of structure. Results: only 46.2% of the maternal healthcare facilities had pre-delivery, parturition and immediate post-partum room. Pediatricians (73.1%) and anesthesiologists (61.5%) were the least present professionals on-duty regime. Regarding drugs, magnesium sulfate and oxytocin were observed in 76.9% of hospitals. Overall adequacy was 23.1%, being higher in maternal healthcare facilities in the capital (p=0.034) and in private ones (p=0.031). Conclusions: Data show inequalities in the structure of maternity hospitals of the state. The absence of health professionals, essential drugs, and appropriate physical structure can expose women and newborns to unnecessary and avoidable risks.
Safety culture in the Neonatal Intensive Care Unit: contributions from the multiprofessional team
Authors: Ventura Maria Williany Silva , Façanha Ana Paula Melo , Néri Eugenie Desirèe Rabelo , Diógenes Mariana da Silva , Lopes Emeline Moura
Published: August 2022

Abstract Objectives: to analyze the patient safety culture with the multidisciplinary team in a neonatal ICU at a Brazilian maternity. Methods: the safety culture was evaluated by the Hospital Survey on Patient Safety Culture (HSOPSC), with a sample of 117 professionals. The questions were divided into 12 domains, classifying them as areas of strength when the percentage was higher than 75% of positive responses. For inferential analysis, Kruskal-Wallis and Chi-square tests were used, considering significant p<0.05 values. Results: the domains ‘organizational learning- continuous improvement’ and ‘teamwork’ were considered as areas of strength in establishing security. Those who needed improvement were: ‘non-punitive response to error’ and ‘staffing’. There was no significant relevance between the crossings of the numbers of positive responses with the professional data, thus showing that the factors did not interfere in the answers given. Conclusions: in view of the results presented, changes are suggested mainly in the aspects related to punitive culture and evaluation of possible reduction of work overload. However, we cannot fail to praise the positive aspects found, such as teamwork, the concern of professionals and managers to bring improvements to promote patient safety.
Возможности для раскрытия и развития талантов детей в общеобразовательных организациях
Authors: Косарецкий Сергей , Анчиков Константин , Мерцалова Татьяна
Published: August 2022

В информационном бюллетене исследуются условия для выявления и развития талантов детей в массовой общеобразовательной школе. Анализируется субъективное восприятие родителями и педагогами детской одаренности, возможностей ее развития на базе школы. Рассматриваются особенности запроса семей на создание условий для выявления и развития талантов. Описывается актуальное положение дел в части специализации школ (или образовательных программ), которая обеспечивает углубленное изучение предметов, профилизацию, индивидуализацию обучения и расширение образовательных возможностей (дополнительные занятия, кружки и секции) на базе школ. Особое внимание уделяется вопросам подготовки и стимулирования педагогов к работе с мотивированными и одаренными учащимися. Исследование основано на результатах опросов обучающихся, их родителей и педагогов общеобразовательных организаций, проведенных в рамках Мониторинга экономики образования в 2020 г.
Self-healing of cyberphysical systems based on the analysis of the results of analytical modeling
Authors: Tkachenko K. S.
Published: August 2022

Cyberphysical systems may have the property of self-healing. To model self-healing processes in cyberphysical systems, it is worth considering the applicability of approaches to assessing the information characteristics of physical systems to complex computer systems. Therefore, it is possible to quantify the degree of degradation and the possibilities for self-healing of the studied cyberphysical computer system based on analytical modeling of the queuing system. Management of self-healing processes of a computer node of a cyberphysical system based on analytical modeling allows to reduce the operational costs of resources for the repair and maintenance of the node, increases the efficiency of the computer node, including by increasing the uptime in an efficient mode, that is, there are qualitative changes in the operation of the cyberphysical system. Self-healing of a cyberphysical system due to self-healing of computer nodes increases the level of its robustness and adaptability to external changes.
How to make noosphere truly noospheric and how much significant is the role of artificial intelligence in this?
Authors: Gorbunov A. P.
Published: August 2022

The transformational-overcointegrative methodology which we use and apply here is based on the outlook that acknowledges the key principle of true unity and entity of all the world. If this key principle is valid – and it is precisely valid – all the world (that is all nature, including human society) in its processing development and transformation is subordinated to general, universal (in fact, even overcogeneralized, overcouniversalized) laws (rules, relationships). And when we cognize and understand these laws in their completeness (in fact, precisely overcocompleteness) we can see the trunk, backbone way of all general, universal evolution (in fact, overcoevolution-overcocreation) and, inside it, of evolution and transformation of human society. All this has been dependently proved and shown in our previous publications. The transformational-overcointegrative methodology accounts the overcogeneralized laws of the all-world systemic development and transformation and is able to overcointegrate, overcogeneralize, overcounite all existing (and even those possible to exist) methodologies and approaches, among them the noosphere approach. Only with the help of this very methodology we are capable to reveal the grounds and mechanism, the relationships of the transformational-creational change of the contemporary society and of its transferring to the stage of truly noospheric noosphere or, in other words, «intelligent intelligence», «conscious consciousness».
Investigation of Plasmodium falciparum mitochondrial ribosomes
Authors:   , Dass Swati , Vaidya Akhil B. , Ke Hangjun
Published: August 2022

Mitochondrial ribosomes (mitoribosomes) in different lineages of eukaryotes are vastly divergent with concomitant increase in the number and size of mitoribosomal proteins (MRPs). This is to accommodate variability in the size of mitochondrial rRNA (mt rRNA) encoded in the mitochondrial genome (mtDNA). Plasmodium spp. contains the smallest mtDNA in eukaryotes that encodes only three mitochondrial electron transport chain (mtETC) proteins; COXI, COXIII and cytochrome b (cyt b), where cyt b is a clinically verified antimalarial drug target. Additionally, this mtDNA encodes rRNA genes that are highly fragmented and scrambled with their lengths ranging from 20-200 nucleotides. Current annotations of Plasmodium MRPs are based on sequence similarities with bacterial and eukaryotic systems. This list does not account for the divergent proteins that perform an unparalleled function of gathering fragmented mt rRNA into a functional ribosome. Using 5 small subunit (SSU) and 2 large subunit (LSU) annotated PfMRPs as tools, we have investigated Plasmodium falciparum mitoribosomes. We were the first to report the essentiality of mitoribosomes in apicomplexan parasites by showing that PfMRPL13 knockdown (KD) exhibits abnormalities in mitochondrial morphology and reduces mtETC activity leading to parasite demise. Moreover, total RNA sequencing of PfRSM22 and PfMRPL23 KD parasites show dramatic changes in the parasite transcriptome that has uncovered some aspects of their potential role in mitoribosomal assembly process. Furthermore, we demonstrate formation of a high molecular weight complex at around 0.8MDa formed by all 7 PfMRPs. Mass spectrometry analyses of one SSU protein (PfMRPS18) display necessary features prior to the formation of assembly intermediates. Additionally, with RNA sequencing and mass spectrometry analyses of PfMRPs, we provide a list of proteins of unknown functions having structural similarities with MRPs from other closely related organisms. These attempts highlight only a small fraction of the mitoribosomes in Plasmodium and their deeper understanding is restricted with the long-standing challenge in the field of Plasmodium biology of isolating its mitochondrion with high purity and concentration. Here we discuss the advancements in establishing a possible workflow to isolate Plasmodium mitochondria that will facilitate further investigation of the unconventional mitoribosomes of malaria parasites.