bluuebunny/crossref_metadata_2025 huggingface dataset:
A Foreground Prototype-Based One-Shot Segmentation of Brain Tumors
Authors: Balasundaram Ananthakrishnan , Kavitha Muthu Subash , Pratheepan Yogarajah , Akshat Dhamale , Kaushik Maddirala Venkata
Published: March 2023

The potential for enhancing brain tumor segmentation with few-shot learning is enormous. While several deep learning networks (DNNs) show promising segmentation results, they all take a substantial amount of training data in order to yield appropriate results. Moreover, a prominent problem for most of these models is to perform well in unseen classes. To overcome these challenges, we propose a one-shot learning model to segment brain tumors on brain magnetic resonance images (MRI) based on a single prototype similarity score. With the use of recently developed few-shot learning techniques, where training and testing are carried out utilizing support and query sets of images, we attempt to acquire a definitive tumor region by focusing on slices containing foreground classes. It is unlike other recent DNNs that employed the entire set of images. The training of this model is carried out in an iterative manner where in each iteration, random slices containing foreground classes of randomly sampled data are selected as the query set, along with a different random slice from the same sample as the support set. In order to differentiate query images from class prototypes, we used a metric learning-based approach based on non-parametric thresholds. We employed the multimodal Brain Tumor Image Segmentation (BraTS) 2021 dataset with 60 training images and 350 testing images. The effectiveness of the model is evaluated using the mean dice score and mean IoU score. The experimental results provided a dice score of 83.42 which was greater than other works in the literature. Additionally, the proposed one-shot segmentation model outperforms the conventional methods in terms of computational time, memory usage, and the number of data.
Cutaneous Sarcoidosis-like Eruption Following Second Dose of Moderna mRNA-1273 Vaccine: Case or Relationship?
Authors: Cazzato Gerardo , Ambrogio Francesca , Foti Caterina , Capuzzolo Marialessandra , Trilli Irma , Casatta Nadia , Lupo Carmelo , Carrieri Marianna , Daini Daniele , Colagrande Anna , Maiorano Eugenio , Ingravallo Giuseppe
Published: March 2023

Various adverse reactions to SARS-CoV-2 vaccines have been described since the first months of the vaccination campaign. In addition to more frequent reactions, rare reactions, such as sarcoidosis-like, rashes have been reported. We present a case of a 23-year-old woman with a rash on the chin and peribuccal region, which developed approximately 3 weeks after the administration of the second dose of the Moderna mRNA-1273 vaccine. We briefly discuss other reports in the literature.
Event-Trigger-Based Finite-Time Privacy-Preserving Formation Control for Multi-UAV System
Authors: Yue Jiangfeng , Qin Kaiyu , Shi Mengji , Jiang Bing , Li Weihao , Shi Lei
Published: March 2023

Privacy-preserving has been crucial technique of multi-UAV systems, including cooperative detection, cooperative penetration and strike. Unprocessed interactive information poses a serious privacy threat to UAV swarm collaborative tasks. Considering not only privacy-preserving but also bandwidth constraints and the convergence performance of multi-UAV systems, this paper comprehensively proposes an original event-triggered-based finite-time privacy-preserving formation control scheme to resolve these three factors. Firstly, this paper adopted a local, deterministic, time-varying output mapping function for a privacy mask, which encodes the internal states of the UAV prior to its public transmission, and the initial true value of each UAV’s states is kept indecipherable for honest-but-curious UAVs and other malicious eavesdropping attackers. Then, considering the limited communication bandwidth and channels, we employed a distributed event-triggered strategy and deduced the triggering condition for consensus-based formation control, which effectively reduces the excessive consumption of communication and computational resources in contrast to time-triggered strategy. In terms of the convergence performance of the UAVs, finite-time stability theory was introduced to make the system reach the desired formation in finite time and obtain a settling time related to the initial state. Compared with the existing literature, this paper systematically took into account the above three factors for multi-UAV systems and provides a convergence analysis and a privacy analysis in detail. Finally, the effectiveness of the finite-time privacy-preserving protocol based on an event-triggered strategy was demonstrated by numerical simulation examples and comparative experiments. The proposed method achieves the formation control under privacy-preserving, improves the convergence rate and reduces the frequency of controller updates and information transmission.
Multi-Physics Coupling Simulation Technique for Phase Stable Cables
Authors: Zhang Gang , Chen Xiao , Yang Dazhi , Wang Lixin , He Xin , Zhang Zhehao
Published: March 2023

This paper is concerned with calculating the phase stability of a phase stable cable with multi-physics coupling simulations. A three-dimensional electromagnetic-thermal-flow-mechanics multi-physics coupling model is established to simulate the phase stable cable operating in air. The simulation results demonstrate that the electric field distribution of the corrugated cable shows differences from that of a normal coaxial cable around the outer conductor, i.e., the electric field is stronger around the sharp points of the outer conductor than the blunt points, which elevates the voltage endurance requirement of the cable and the risk of breakdown during the transmission of high power. Regarding the thermal deformation, simulations reveal that the corrugated outer conductor restrains the insulation from expanding along both the cross-section direction and the axial direction, and the thermal expansion might be manipulated through the proper design of the outer conductor parameters. Finally, the consistency between the simulated and measured results of phase stability witnesses the validity of the multi-physics coupling model, and its accuracy might be refined with more precise material properties.
The “Smart” Concept from an Electrical Sustainability Viewpoint
Authors: Llanez-Caballero Ignacio , Ibarra Luis , Peña-Quintal Angel , Catzín-Contreras Glendy , Ponce Pedro , Molina Arturo , Ramirez-Mendoza Ricardo
Published: March 2023

Nowadays, there are many technological-intensive applications that claim to be “smart”. From smartphones to the smart grid, people relate the word smart with technical novelty, automation, enabled communication, and service integration. There is indeed a gap between those smart technologies and their intended “intelligence”; this has arisen an indirect debate between works focusing on automation and mechatronics design and others pursuing a conceptual approach based on fulfilling determinate objectives. One last approach relates the said smartness to deep learning methodologies. In this work, it is attempted to explore both perspectives by providing an overview of recent works around energy usage toward smart cities and the smart grid, pointing out the main conceptual pillars upon which both approaches stand. Certainly, there are enabling technologies supporting the smart concept overall; thus, this work addresses them to characterize “smart” not from technological or conceptual one-sided viewpoints but from their common backbone. Therefore, the interested reader can find in this work an integrative conceptualization of the smart context, a literature review of recent advances, and a deep discussion of how enabling technologies and current technological trends based on energy consumption are shaping the ongoing efforts toward a sustainable future. More importantly, a new approach to define smart in the said context is elaborated far from the typical misunderstanding of technological nesting or mere usage of “advanced” digital technologies. Rather, smartness is addressed by the integrative objectives the application pursues, the objectives set by its users’ intent, and the attained results in terms of public benefit.
Effect of a Vibrating Blade in a Channel on the Heat Transfer Performance
Authors: Yuan Xinrui , Lan Chenyang , Hu Jinqi , Fan Yuanhong , Min Chunhua
Published: March 2023

A vibrating blade was arranged in a channel to enhance heat transfer. The effects of the frequency and amplitude of the blade on the heat transfer characteristics were numerically researched. The phase space reconstruction and maximum Lyapunov index were used to analyze the transition path and degree of chaos. The results show that the vibrating blade can generate chaos; thus, the heat transfer is enhanced. The convective heat transfer performance is positively correlated with the degree of chaos. In addition, when the frequency is 10 Hz, and the inlet velocity is 0.5 m s−1, the heat transfer can be improved by 16%. When the maximum amplitude of the blade is 8 mm and the inlet velocity is 0.8 m s−1, the heat transfer can be improved by 15%.
A Hybrid Feature Pyramid CNN-LSTM Model with Seasonal Inflection Month Correction for Medium- and Long-Term Power Load Forecasting
Authors: Cheng Zizhen , Wang Li , Yang Yumeng
Published: March 2023

Accurate medium- and long-term power load forecasting is of great significance for the scientific planning and safe operation of power systems. Monthly power load has multiscale time series correlation and seasonality. The existing models face the problems of insufficient feature extraction and a large volume of prediction models constructed according to seasons. Therefore, a hybrid feature pyramid CNN-LSTM model with seasonal inflection month correction for medium- and long-term power load forecasting is proposed. The model is constructed based on linear and nonlinear combination forecasting. With the aim to address the insufficient extraction of multiscale temporal correlation in load, a time series feature pyramid structure based on causal dilated convolution is proposed, and the accuracy of the model is improved by feature extraction and fusion of different scales. For the problem that the model volume of seasonal prediction is too large, a seasonal inflection monthly load correction strategy is proposed to construct a unified model to predict and correct the monthly load of the seasonal change inflection point, so as to improve the model’s ability to deal with seasonality. The model proposed in this paper is verified on the actual power data in Shaoxing City.
Optimisation of a Gas-Lifted System with Nonlinear Model Predictive Control
Authors: Adukwu Ojonugwa , Odloak Darci , Kassab Fuad
Published: March 2023

A gas-lifted system in a mature oil well can experience casing-heading instability, which reduces the mean oil production and it is not healthy for the downstream equipment. This instability was removed by implementing a terminal equality-constrained nonlinear model predictive control (NMPC) having input targets with control zones in the system. The input-dependent stability behaviour of the gas-lifted system was visualised through the bifurcation diagram and the step responses of the linearised model at various operating points. The controller was then presented. Then, the close-loop feasibility, as well as the convergence, were discussed. The controller stabilised the undisturbed gas-lifted system, improving production by 5.63% compared to the open-loop operation when the system was in casing-heading instability. For the two input case, the steady-state production, aided by the high-input target, reached 12.25 kg/s, which was far more than 9.57 kg/s for the one input case. This controller showed a 3.76% improvement over the PI controller for the same purpose.
Wireless Power Transfer in Electric Vehicles: A Review on Compensation Topologies, Coil Structures, and Safety Aspects
Authors: Rayan Benitto Albert , Subramaniam Umashankar , Balamurugan S.
Published: March 2023

The scarce availability of non-renewable sources and the staggering amount of pollution have inevitably provoked many countries to opt for renewable sources. Thence, invariably, more renewable energy-based applications are hoarded by market stakeholders. Compared to all spheres of renewable energy applications, a considerable part of the energy is pulled into transportation. Wireless power transfer techniques play a significant role in charging infrastructure, considering the current development and advancement in the automotive industry. It will promise to overcome the widely known drawbacks of wired charging in electric vehicles. The effectiveness of wireless charging depends on coil design, compensation techniques, and the airgap between the coils. However, coil misalignment, improper compensation topologies, and magnetic materials reduce the efficacy. We can improve efficacy by overcoming the problems mentioned above and optimizing charging distance, time, and battery size. This paper comprehensively discussed the various electric vehicle charging technologies in conjunction with common charging standards, a list of factors affecting the charging environment, and the significance of misalignment problems. Furthermore, this review paper has explored the suitable coil design structure and different compensation techniques for an efficient wireless charging network.
A Novel Scheme to Allocate the Green Energy Transportation Costs—Application to Carbon Captured and Hydrogen
Authors: Benetti Marcelo Azevedo , Iov Florin
Published: March 2023

Carbon dioxide (CO2) and hydrogen (H2) are essential energy vectors in the green energy transition. H2 is a fuel produced by electrolysis and is applied in heavy transportation where electrification is not feasible yet. The pollutant substance CO2 is starting to be captured and stored in different European locations. In Denmark, the energy vision aims to use this CO2 to be reacted with H2, producing green methanol. Typically, the production units are not co-located with consumers and thus, the required transportation infrastructure is essential for meeting supply and demand. This work presents a novel scheme to allocate the transportation costs of CO2 and H2 in pipeline networks, which can be applied to any network topology and with any allocation method. During the tariff formation process, coordinated adjustments are made by the novel scheme on the original tariffs produced by the allocation method employed, considering the location of each customer connected to pipeline network. Locational tariffs are provided as result, and the total revenue recovery is guaranteed to the network owner. Considering active customers, the novel scheme will lead to a decrease of distant pipeline flows, thereby contributing to the prevention of bottlenecks in the transportation network. Thus, structural reinforcements can be avoided, reducing the total transportation cost paid by all customers in the long-term.
Remaining-Useful-Life Prediction for Li-Ion Batteries
Authors: Chang Yeong-Hwa , Hsieh Yu-Chen , Chai Yu-Hsiang , Lin Hung-Wei
Published: March 2023

This paper aims to establish a predictive model for battery lifetime using data analysis. The procedure of model establishment is illustrated in detail, including the data pre-processing, modeling, and prediction. The characteristics of lithium-ion batteries are introduced. In this study, data analysis is performed with MATLAB, and the open-source battery data are provided by NASA. The addressed models include the decision tree, nonlinear autoregression, recurrent neural network, and long short-term memory network. In the part of model training, the root-mean-square error, integral of the squared error, and integral of the absolute error are considered for the cost functions. Based on the defined health indicator, the remaining useful life of lithium-ion batteries can be predicted. The confidence interval can be used to describe the level of confidence for each prediction. According to the test results, the long short-term memory network provides the best performance among all addressed models.
Changes in Plant Diversity and Soil Factors under Different Rocky Desertification Degrees in Northern Guangdong, China
Authors: Lan Mingyu , Xue Chunquan , Yang Jiazhi , Wang Ning , Sun Chuanxi , Wu Guozhang , Chen Hongyu , Su Zhiyao
Published: March 2023

Revegetation is an important restoration strategy for the control of rocky desertification. However, few studies have focused on the effects of different rocky desertification degrees (RDDs) on plant diversity and soil fertility in northern Guangdong over long periods of time. In this study, variance analysis, correlation analysis, and canonical correlation analysis (CCA) were used to examine plant diversity, soil physicochemical properties, and their correlations in various rocky desertification areas in northern Guangdong. The results showed that the Pinaceae, Lauraceae, and Fagaceae species were relatively abundant in the rocky desertification areas of northern Guangdong. Additionally, Cinnamomum camphora, Schima superba, Pinus massoniana, Quercus stewardiana, and Acer camphora could be used as indicators for rocky desertification. There were significant differences in plant community compositions and diversity characteristics between the five RDDs, and the vegetation exhibited the trend of initial destruction and then gradual improvement and stabilization. There were significant differences in soil bulk density, mechanical composition, organic matter, total nitrogen, alkaline hydrolysis nitrogen, and available potassium between the different RDDs. Except for pH, the soil chemical characteristics all had clear aggregation effects. Soil organic matter, total nitrogen, total potassium, and alkaline hydrolysis nitrogen all exhibited degradation–improvement cycles. The correlation analysis revealed that there was a significant correlation between soil physicochemical properties and species diversity. The CCA analysis showed that the most important soil factors affecting plant community structures were total phosphorus and available phosphorus. In conclusion, some achievements have been made in the restoration of rocky desertification in northern Guangdong; while the plant community structure improved, some soil nutrients also improved. Vegetation and soil have a strong coupling relationship. In the later stages of recovery, suitable species for rocky desertification could be considered in varying degrees and P and K could be supplemented appropriately. Our study will have implications for the revegetation of rocky desertification.
PIP2;10 Enhances Drought Tolerance via Promoting Water-Retaining Capacity in Populus
Authors: Yu Xiao-Qian , Su Wanlong , Liu Chao , Wang Hou-Ling , Yin Weilun , Xia Xinli
Published: March 2023

Drought is an adverse environmental factor for plant growth and development. Aquaporins play an influential role in water uptake and transport in plants. However, the function of PagPIP2;10 in response to drought stress remains largely unclear. Here, we report that the plasma membrane intrinsic protein PagPIP2;10 was in the cell membrane and induced by dehydration in the poplar 84K hybrids. The overexpression of PagPIP2;10 in poplars enhanced drought tolerance. The PagPIP2;10ox lines maintained a higher water retention content, photosynthetic rate, and proline content. Meanwhile, a lower content of MDA and transpiration and stomatal conductance were observed under drought stress than in that of the WT plants. A further analysis found that the PagPIP2;10ox lines decreased the stomatal aperture and accumulated more ROS in guard cells compared with WT after ABA treatment with the exception that the root hydraulic conductance of the PagPIP2;10ox lines was higher than that of the WT plants. These results imply that PagPIP2;10 played a positive role in enhancing drought stress via enhancing water-retaining capacity under drought stress.
The Impact of Predation of Laricobius nigrinus (Coleoptera: Derodontidae) on Adelges tsugae (Hemiptera: Adelgidae) and Tsuga canadensis (Pinales: Pinaceae) Tree Health
Authors: Preston Carrie E. , Arneson Alicia , Seiler John R. , Salom Scott M.
Published: March 2023

The hemlock woolly adelgid (HWA), Adelges tsugae, has threatened the sustainable management of Tsuga canadensis in the eastern United States. Biological control efforts have led to the establishment of Laricobius nigrinus, a specialist predator of HWA. Although L. nigrinus has a significant impact on HWA populations, its effect on the health of HWA’s host is unknown. In 2020, 14 eastern hemlocks at one site in Virginia were selected to determine whether predation of L. nigrinus at different densities on HWA populations had an effect on tree health. Laricobius nigrinus predation significantly impacted the HWA sistens generation, resulting in significantly more new shoots produced on treatment branches with the greatest density of L. nigrinus adults. Final HWA density was lowest on treatment branches with L. nigrinus, followed by the negative control, and the treatment without L. nigrinus. In June, the photosynthetic rate was significantly greater for the negative control, followed by L. nigrinus treatments. There were no statistical differences among measured tree physiological parameters in July and October, indicating a temporary effect from L. nigrinus predation on hemlock tree physiology.
A Study of the Metabolic Profiles of Penicillium dimorphosporum KMM 4689 Which Led to Its Re-Identification as Penicillium hispanicum
Authors: Nesterenko Liliana E. , Popov Roman S. , Zhuravleva Olesya I. , Kirichuk Natalya N. , Chausova Viktoria E. , Krasnov Kirill S. , Pivkin Mikhail V. , Yurchenko Ekaterina A. , Isaeva Marina P. , Yurchenko Anton N.
Published: March 2023

Changes in cultivation conditions, in particular salinity and temperature, affect the production of secondary fungal metabolites. In this work, the extracts of fungus previously described as Penicillium dimorphosporum cultivated in various salinity and temperature conditions were investigated using HPLC UV/MS techniques, and their DPPH radical scavenging and cytotoxicity activities against human prostate cancer PC-3 cells and rat cardiomyocytes H9c2 were tested. In total, 25 compounds, including 13 desoxyisoaustamide-related alkaloids and eight anthraquinones, were identified in the studied extracts and their relative amounts were estimated. The production of known neuroprotective alkaloids 5, 6 and other brevianamide alkaloids was increased in hypersaline and high-temperature conditions, and this may be an adaptation to extreme conditions. On the other hand, hyposalinity stress may induce the synthesis of unidentified antioxidants with low cytotoxicity that could be very interesting for future investigation. The study of secondary metabolites of the strain KMM 4689 showed that although brevianamide-related alkaloids and anthraquinone pigments are widely distributed in various fungi, these metabolites have not been described for P. dimorphosporum and related species. For this reason, the strain KMM 4689 was re-sequenced using the β-tubulin gene and ITS regions as molecular markers and further identified as P. hispanicum.
Fish Size Correlates to Size and Morphology of Intermuscular Bones in Tambaqui Colossoma macropomum as Shown by Dissection and X-ray Imaging Methods
Authors: Oliveira Naislan F. A. , Torati Lucas S. , Borin-Carvalho Luciana A. , de Lima Leandro K. F. , Puvanendran Velmurugu , Demiciano Thaís H. , da Silva José J. T. , Barroso Aurisan da S. , Varela Eduardo S.
Published: March 2023

One of the main issues in the processing sector of the tambaqui Colossoma macropomum is the removal and/or fragmentation of intermuscular bones (IBs), which negatively impacts its production chain. In this sense, we quantitatively examined the IB variation in farmed tambaqui (n = 127) by comparing the direct anatomical dissection with the high-resolution X-ray imaging method. The number of IBs from the anatomical dissection on the left side of the fish (27.3 ± 5.70 bones) was comparable to that of X-ray analysis (26.9 ± 6.03 bones) (p > 0.05). In addition, 76% of deviation in IB number between the two studied methods was one to three, indicating both methods are equally efficient for identifying and quantifying IBs. We found a strong positive correlation (R = 0.8, p < 0.001) between the X-ray and the dissection methods. Our predictive models indicated that more than 50% of variation in IB length can be explained by growth parameters. Our results demonstrated that the X-ray method can provide accurate phenotypic data (in vivo) for IB counting and length measurements by extrapolating from the standard length, body weight and trunk over axis area of tambaqui.
Melatonin Treatment of Strawberry Fruit during Storage Extends Its Post-Harvest Quality and Reduces Infection Caused by Botrytis cinerea
Authors: Promyou Surassawadee , Raruang Yenjit , Chen Zhi-Yuan
Published: March 2023

Gray mold is a main disease of strawberry fruit (Fragaria × xananassa cv. Camino Real) caused by Botrytis cinerea, which leads to marketable value losses in the supply chain. The purpose of this study was to investigate the effects of exogenous melatonin (MT) on the physicochemical quality, antioxidant defense system, and disease resistance of strawberry fruit to B. cinerea infection. The results revealed that strawberry fruit immersed in 100 µM MT for 15 min effectively maintained its brightness and delayed the change in fruit color. MT also maintained the level of titratable acidity and slowed down the increase of total soluble solids in strawberry fruit. Moreover, strawberries immersed in MT maintained a fresh weight and fruit firmness, as well as reduced B. cinerea infection when compared to the untreated control fruit and fruit treated with 5% NaOCl. In addition, MT increased the accumulation of DPPH scavenging capacity and the activity of antioxidant enzymes (SOD, POD, and APX) with the exception of CAT. The same effect was also observed in strawberry fruit after immersion in MT and followed by B. cinerea inoculation. These findings demonstrated that exogenous MT could effectively maintain the postharvest quality of strawberries, even when the fruit was inoculated with B. cinerea.
Transcriptome Analysis in Pyrus betulaefolia Roots in Response to Short-Term Boron Deficiency
Authors: Liu Jing , Chen Tao , Wang Chun-Lei , Liu Xiao
Published: March 2023

Boron (B) deficiency stress is frequently observed in pear orchards and causes a considerable loss of productivity and fruit quality. Pyrus betulaefolia is one of the most important rootstocks that has been widely used in pear production. The present study confirmed that the boron form of different tissues showed various changes, and the free boron content was significantly decreased under the short-term B deficiency condition. Moreover, the ABA and JA content also significantly accumulated in the root after short-term B deficiency treatment. A comprehensive transcriptome analysis of 24 h B deficiency treatment P. betulaefolia root was performed in this study. Transcriptome results revealed a total of 1230 up-regulated and 642 down-regulated differentially expressed genes (DEGs), respectively. B deficiency significantly increased the expression of the key aquaporin gene NIP5-1. In addition, B deficiency also increased the expression of ABA (ZEP and NCED) and JA (LOX, AOS and OPR) synthesis genes. Several MYB, WRKY, bHLH and ERF transcription factors were induced by B deficiency stress, which may relate to the regulation of B uptake and plant hormone synthesis. Overall, these findings suggested that P. betulaefolia root had adaptive responses to short-term B deficiency stress by improved boron absorption ability and hormone (JA and ABA) synthesis. The transcriptome analysis provided further information for understanding the mechanism of the pear rootstock responses to B deficiency stress.
The Associations of Pulse Pressure and Mean Arterial Pressure on Physical Function in Older Americans
Authors: Pleiss Abigail , Jurivich Donald , Dahl Lindsey , McGrath Brenda , Kin Daniela , McGrath Ryan
Published: March 2023

Background: We sought to examine the associations of pulse pressure (PP) and mean arterial pressure (MAP) on physical function in older Americans. Methods: Our analytic sample included 10,478 adults aged ≥65 years from the 2006–2016 Health and Retirement Study. Handgrip strength, gait speed, and standing balance were collected using relatively standard protocols. PP and MAP were calculated from blood pressure measurements. Results: Older Americans with any abnormality in PP had 1.15 (95% confidence interval (CI): 1.05–1.25) greater odds for slowness and 1.14 (CI: 1.05–1.24) greater odds for poorer standing balance. Persons with any abnormality in MAP had 0.90 (CI: 0.82–0.98) decreased odds for weakness and 1.10 (CI: 1.01–1.20) greater odds for poorer standing balance. Those with low PP had 1.19 (CI: 1.03–1.36) greater odds for slow gait speed, while persons with low MAP had 1.50 (CI: 1.09–2.05) greater odds for weakness and 1.45 (CI: 1.03–2.04) greater odds for slowness. Older Americans with high PP had 1.13 (CI: 1.03–1.25) greater odds for slowness and 1.21 (CI: 1.10–1.32) greater odds for poorer balance, whereas those with high MAP had 0.87 (CI: 0.80–0.95) decreased odds for weakness. Conclusions: Cardiovascular dysfunction, as observed by PP and MAP, may help to explain some of our findings.
Physical Training Programs for Tactical Populations: Brief Systematic Review
Authors: Rasteiro André , Santos Vanessa , Massuça Luís Miguel
Published: March 2023

This review aims (i) to identify and analyze the physical training programs used for tactical personnel (TP) and (ii) to understand the effects of physical training programs on the health and fitness, and occupational performance of tactical personnel. A literature search used the keywords ‘Physical Training Program’, ‘Police’, ‘Law Enforcement’, and ‘Firefighter’. A total of 23 studies out of 11.508 analyzed were included. All studies showed acceptable methodological quality in assessing physical fitness (PF), and training programs’ effect sizes (Cohen’s d) on PF attributes were calculated. The results showed that physical training programs (duration > four weeks) can improve (medium-to-large effects) (i) measures of physical fitness and (ii) performance in simulations of occupationally specific tasks. This review provides summary information (i) to help select (or adjust) physical training programs for TP and (ii) to clarify the effect of different occupational-specific training interventions on fitness measures and health-related parameters for TP.
Body Donation Registration in Taiwan: Reasons and Associated Psychological Factors
Authors: Chen Wan-Lan
Published: March 2023

Dissection is an essential element of medical training and depends on the availability of cadavers. However, traditional Chinese culture widely regards the body as a gift from one’s parents that should remain intact after death, resulting in a shortage of cadavers for medical training and research. This situation changed in Taiwan when Master Cheng Yen, the founder of the Buddhist Tzu Chi Medical Foundation, supported the donation of bodies to medical science. This study aimed to investigate the current situation of body donation in Taiwan, including donors’ motivation and psychological characteristics. A questionnaire was conducted with 681 adult participants, including 336 people who pledged to donate their bodies to medical science after death and a control group comparable in age, gender, and level of education. All participants answered questions regarding anxiety over death, purpose in life, gratitude, altruism, and life satisfaction. In addition, the registered donor group answered questions regarding the motivation for donating their bodies to science. The main influencing factors were to help advance medical science, make a positive contribution to society, and release attachment from the body. Further, many male participants indicated the desire to reduce trouble and expenses that their families would incur in making funeral and burial or cremation arrangements. The main predictors of donating one’s body to medical science were low anxiety concerning death, a high level of altruism, and gratitude.
Work Ability and Well-Being Management and Its Barriers and Facilitators in Multinational Organizations: A Scoping Review
Authors: Shiri Rahman , Bergbom Barbara
Published: March 2023

The aim of this scoping review was to identify effective workplace programs for work ability and well-being management and its barriers and facilitators in multinational organizations. The PubMed, Embase, and Web of Science databases were searched from 1974 through February 2023 to identify quantitative and qualitative studies on the management of work ability and well-being, and related outcomes including presenteeism, absenteeism, productivity loss, and healthy practices, conducted in a multinational organization or company. The titles and abstracts of over 11,000 publications were screened, and 10 studies fulfilling the inclusion criteria were included in the review. The management of work ability and well-being in multinational companies requires leadership support and commitment, effective communication, employee health awareness and engagement, comprehensive personalized health risk and condition assessments, and the management of risk factors and occupational and non-occupational health conditions. Financial constraints, high workloads, competing priorities, a lack of effective communication, a lack of worksite managers’ motivation, employees’ language barriers, high worksite managers’ turnover, and a decline in the support of senior managers are considered as barriers, and the presence of existing participatory practices is considered as a facilitator of participation in workplace health and well-being interventions in multinational companies. This review suggests that the management of work ability and well-being in multinational companies should go beyond health promotion and include comprehensive personalized health risk and health condition assessments and management.
Interrupted Time Series Analysis: Patient Characteristics and Rates of Opioid-Use-Disorder-Related Emergency Department Visits in the Los Angeles County Public Hospital System during COVID-19
Authors: Johnson Emily , Axeen Sarah , Vosooghi Aidan , Lam Chun Nok , Bluthenthal Ricky , Schneberk Todd
Published: March 2023

The COVID-19 pandemic led to disruptions in care for vulnerable patients, in particular patients with opioid use disorder (OUD). We aimed to examine OUD-related ED visits before and during the COVID-19 pandemic and determine if patient characteristics for OUD-related ED visits changed in the context of the pandemic. We examined all visits to the three public safety net hospital EDs in Los Angeles County from April 2019 to February 2021. We performed interrupted time series analyses examining OUD-related ED visits from Period 1, April 2019 to February 2020, compared with Period 2, April 2020 to February 2021, by race/ethnicity and payor group. We considered OUD-related ED visits as those which included any of the following: discharge diagnosis related to OUD, patients administered buprenorphine or naloxone while in the ED, and visits where a patient was prescribed buprenorphine or naloxone on discharge. There were 5919 OUD-related ED visits in the sample. OUD-related visits increased by 4.43 (2.82–6.03) per 1000 encounters from the pre-COVID period (9.47 per 1000 in February 2020) to the COVID period (13.90 per 1000 in April 2020). This represented an increase of 0.41/1000 by white patients, 0.92/1000 by black patients, and 1.83/1000 by Hispanic patients. We found increases in OUD-related ED visits among patients with Medicaid managed care of 2.23/1000 and in LA County safety net patients by 3.95/1000 ED visits. OUD-related ED visits increased during the first year of the COVID pandemic. These increases were significant among black, white, and Hispanic patients, patients with Medicaid managed care, and LA County Safety net patients. These data suggest public emergency departments served as a stopgap for patients suffering from OUD in Los Angeles County during the pandemic and can be utilized to guide preventative interventions in vulnerable populations.
Three Different Fertilizers Enhance Spinach Growth and Reduce Spinach Cd Concentration in Cd Contaminated Alkaline Soil
Authors: Pan Yingjie , Xu Xiangnan , Lang Qianqian , Liao Shangqiang , Li Yanmei
Published: March 2023

In order to investigate the impact of peach branch derived fertilizer (PB), cow manure derived fertilizer (CM) and silicon liquid fertilizer (Si) on the growth and Cd uptake of the Spinacia oleracea L. in the Cd contaminated soil, a pot experiment was conducted. The fertilizers were applied with low (L), medium (M) or high (H) levels, leading to nine treatments and a control group (CK). As a result, compared to CK, PB increased shoot dry mass by 15 to 46% and reduced shoot Cd by 19 to 56%; CM increased shoot dry mass by 6.1 to 162% and reduced shoot Cd by 38 to 55%; Si showed no effect on plant biomass but significantly reduced the root Cd bioconcentration factor. The CMM and CMH significantly reduced soil-available Cd by 6.5 and 7.5%, respectively, compared to CK. The CM enhanced the plant biomass dilution of Cd and decreased soil-available Cd, but led to higher total shoot Cd accumulation. PB led to simultaneous decline of the shoot Cd and total shoot Cd accumulation, indicating a stronger plant Cd “rejection” effect, independent from biomass accumulation. Si reduced plant root Cd with the sacrifice of biomass accumulation.
Social Media and the Influence of Fake News on Global Health Interventions: Implications for a Study on Dengue in Brazil
Authors: Gagnon-Dufresne Marie-Catherine , Azevedo Dantas Mayana , Abreu Silva Kellyanne , Souza dos Anjos Jean , Pessoa Carneiro Barbosa Delano , Porto Rosa Rebeca , de Luca William , Zahreddine Monica , Caprara Andrea , Ridde Valéry , Zinszer Kate
Published: March 2023

Social media usage is growing globally, with an exponential increase in low- and middle-income countries. Social media changes the ways in which information-sharing occurs, intensifying the population’s exposure to misinformation, including fake news. This has important repercussions for global health. The spread of fake news can undermine the implementation of evidence-based interventions and weaken the credibility of scientific expertise. This is particularly worrisome in countries, such as Brazil, in a sociopolitical context characterized by a lack of popular trust in public institutions. In this project report, we describe our experience with the spread of fake news through the social media platform WhatsApp during the implementation of a cluster randomized controlled trial aimed at reducing dengue incidence in children in Fortaleza (Brazil). During initial visits to selected clusters, the research team was met with resistance. Then, soon after data collection started, fake news began circulating about the study. As a result, the research team developed strategies to dispel suspicion and further promote the study. However, the climate of violence and mistrust, coupled with the COVID-19 pandemic, forced the interruption of the study in 2019. The lessons learned from our experience in Fortaleza can be useful to other researchers and practitioners implementing large-scale interventions in this era of health-related misinformation.
The Judgments and Emotion Attributions in Peer Exclusion Situations among Fourth, Sixth, and Eighth Graders in Japan
Authors: Hasegawa Mari
Published: March 2023

This study examined the judgments and emotion attributions in peer exclusion situations among Japanese middle-childhood children (fourth graders and sixth graders) and adolescents (eighth graders). In total, 371 participants were presented with one of three bystander conditions—no bystander, passive bystander, or active bystander—and asked to judge the excluders’ behavior and attribute emotions toward excluders. Here, excluders are children who physically or emotionally separate other children from social groups. All scenarios involved a child wishing to join a peer group but was rejected (that is, excluded from the group), and there were three types of situations: one in which there were no bystanders, one in which the bystanders did not respond, and one in which the bystanders allowed the excluded child into their group. The excluded target was presented as either violent or shy. Furthermore, the participants assessed their own bullying and bystander behaviors in their daily lives. Adolescents judged excluders as less immoral and as having positive emotions more often than did children. Both children and adolescents judged the exclusion of violent targets to be less serious than the exclusion of shy targets. There were no differences in judgments and attributions according to bystander types. There was weak evidence of a relationship between self-reported bullying/bystander behavior, and judgment in fictitious settings was obtained.
Construction of a Musculoskeletal Discomfort Scale for the Lower Limbs of Workers: An Analysis Using the Multigroup Item Response Theory
Authors: da Silva Joel Gomes , da Silva Jonhatan Magno Norte , Bispo Lucas Gomes Miranda , de Souza Deividson Sá Fernandes , Serafim Rômulo Silva , Torres Manoel Gerônimo Lino , Leite Wilza Karla dos Santos , Vieira Elamara Marama de Araujo
Published: March 2023

Musculoskeletal symptoms are a major occupational health problem in workers, and these can affect all professional occupations. Previous studies have proposed metrics capable of evaluating the musculoskeletal discomfort experienced by workers. However, no study has developed a metric that considers professional groups. Thus, this study aimed to develop a scale for musculoskeletal discomfort in the lower limbs to compare self-reported symptoms among education, health, and industry professionals. The sample included 159 teachers, 167 health professionals, and 401 industrial operators who relayed their symptoms using a diagram of the hips, thighs, knees, lower legs, and feet. Factor and multigroup item response theory analyses were used to construct a musculoskeletal discomfort scale consisting of seven levels and to assess and compare the identified symptoms. The results showed that the progressive evolution of discomfort differed for each profession, demonstrating that each context and work environment affects workers differently, which may explain the different patterns of symptom responses among professional groups.
Roles of p53-Mediated Host–Virus Interaction in Coronavirus Infection
Authors: Wang Xue , Liu Yi , Li Kaiyuan , Hao Zhihui
Published: March 2023

The emergence of the SARS-CoV-2 coronavirus has garnered global attention due to its highly pathogenic nature and the resulting health crisis and economic burden. Although drugs such as Remdesivir have been considered a potential cure by targeting the virus on its RNA polymerase, the high mutation rate and unique 3’ to 5’ exonuclease with proofreading function make it challenging to develop effective anti-coronavirus drugs. As a result, there is an increasing focus on host–virus interactions because coronaviruses trigger stress responses, cell cycle changes, apoptosis, autophagy, and the dysregulation of immune function and inflammation in host cells. The p53 tumor suppressor molecule is a critical regulator of cell signaling pathways, cellular stress responses, DNA repair, and apoptosis. However, viruses can activate or inhibit p53 during viral infections to enhance viral replication and spread. Given its pivotal role in cell physiology, p53 represents a potential target for anti-coronavirus drugs. This review aims to summarize the relationship between p53 and coronaviruses from various perspectives, to shed light on potential targets for antiviral drug development and vaccine design.
Mesenchymal Stromal Cells as a Driver of Inflammaging
Authors: Lyamina Svetlana , Baranovskii Denis , Kozhevnikova Ekaterina , Ivanova Tatiana , Kalish Sergey , Sadekov Timur , Klabukov Ilya , Maev Igor , Govorun Vadim
Published: March 2023

Life expectancy and age-related diseases burden increased significantly over the past few decades. Age-related conditions are commonly discussed in a very limited paradigm of depleted cellular proliferation and maturation with exponential accumulation of senescent cells. However, most recent evidence showed that the majority of age-associated ailments, i.e., diabetes mellitus, cardiovascular diseases and neurodegeneration. These diseases are closely associated with tissue nonspecific inflammation triggered and controlled by mesenchymal stromal cell secretion. Mesenchymal stromal cells (MSCs) are known as the most common type of cells for therapeutic approaches in clinical practice. Side effects and complications of MSC-based treatments increased interest in the MSCs secretome as an alternative concept for validation tests in regenerative medicine. The most recent data also proposed it as an ideal tool for cell-free regenerative therapy and tissue engineering. However, senescent MSCs secretome was shown to hold the role of ‘key-driver’ in inflammaging. We aimed to review the immunomodulatory effects of the MSCs-secretome during cell senescence and provide eventual insight into the interpretation of its beneficial biological actions in inflammaging-associated diseases.
E-Cigarette Aerosol Condensate Leads to Impaired Coronary Endothelial Cell Health and Restricted Angiogenesis
Authors: Chhor Michael , Tulpar Esra , Nguyen Tara , Cranfield Charles G. , Gorrie Catherine A. , Chan Yik Lung , Chen Hui , Oliver Brian G. , McClements Lana , McGrath Kristine C.
Published: March 2023

Cardiovascular disease (CVD) is a leading cause of mortality worldwide, with cigarette smoking being a major preventable risk factor. Smoking cessation can be difficult due to the addictive nature of nicotine and the withdrawal symptoms following cessation. Electronic cigarettes (e-Cigs) have emerged as an alternative smoking cessation device, which has been increasingly used by non-smokers; however, the cardiovascular effects surrounding the use of e-Cigs remains unclear. This study aimed to investigate the effects of e-Cig aerosol condensate (EAC) (0 mg and 18 mg nicotine) in vitro on human coronary artery endothelial cells (HCAEC) and in vivo on the cardiovascular system using a mouse model of ‘e-vaping’. In vitro results show a decrease in cell viability of HCAEC when exposed to EAC either directly or after exposure to conditioned lung cell media (p < 0.05 vs. control). Reactive oxygen species were increased in HCAEC when exposed to EAC directly or after exposure to conditioned lung cell media (p < 0.0001 vs. control). ICAM-1 protein expression levels were increased after exposure to conditioned lung cell media (18 mg vs. control, p < 0.01). Ex vivo results show an increase in the mRNA levels of anti-angiogenic marker, FKBPL (p < 0.05 vs. sham), and endothelial cell adhesion molecule involved in barrier function, ICAM-1 (p < 0.05 vs. sham) in murine hearts following exposure to electronic cigarette aerosol treatment containing a higher amount of nicotine. Immunohistochemistry also revealed an upregulation of FKBPL and ICAM-1 protein expression levels. This study showed that despite e-Cigs being widely used for tobacco smoking cessation, these can negatively impact endothelial cell health with a potential to lead to the development of cardiovascular disease.