The brown alga Laminaria ochroleuca: Charming shell pickers of the strait of Messina, fanciful sirens, and treating war wounds and scars in prostitutes
Authors: Brzezinski Piotr , Martini Lorenzo 
Published: June 2022

Sir, In one of his precious masterpieces, Portuguese novelist José Saramago narrates in detail the lives of the rice weeders who used to work in this land and, after a day of work, soak their bare feet in a bath with hot water, salt, mallow, and chamomile in order to restore their ankles, swollen and inflated for the alga native to these particular paddy fields, Laminaria ochroleuca (Bachelot de la Pylaie), extremely rich in fucose and alginates, provoking an accelerated and paroxistic synthesis of elastin, fibronectin, and collagen. This brown alga may be retrieved from the waters of France, Spain, Scotland, and the Shetland Islands, yet even in the Azores Islands and Morocco (Alboran Sea) [1–4]. The authors of this paper selected a special Laminaria from the Strait of Messina (Nereocystis luetkeana), a heterokont that is able to grow half a meter per day reaching the surprising and amazing height of 260 ft.). The legend has it that shell collectors, chiefly young girls, day after day, saw their legs together to create the tail of a siren, a cartilaginous appendage rich in collagen and elastin becoming scaly and squamous owing to the seawater. The authors created a dermocosmetic emulsion with high concentrations of acetolyte from Laminaria ochroleuca (12%) and other nourishing active ingredients (obviously, the chief components were petrolatum and lanolin, as per the pharmaceutical art of preparing the cold cream of Galenus). Hence, this golden alga is able to support the skin by providing antioxidants to fight free radicals, supporting the health of collagen and elastin, which helps the skin retain elasticity and radiance, reducing fine lines and wrinkles and helping to moisturize the skin while boosting its barrier. Some researchers [5] claimed that this alga could be useful to build a skin equivalent, as fucoidan significantly stimulates the proliferation of CCD-25Sk human fibroblasts. Also, western blot analysis demonstrates that fucoidan markedly increases the expression of cyclin D1 and decreases the expression of p27. Fucoidan was practically used to reconstruct SE. Immunohistochemical staining reveals that the addition of fucoidan to dermal equivalents increases the expression of proliferating cell nuclear antigen (PCNA) and p63. In addition, the expression of a6-integrin is significantly increased by fucoidan, whereas the expression of b1-integrin, type 1 collagen, elastin, and fibronectin does not markedly change. In the light of the above, the authors may assert that fucoidan shows positive effects on epidermal reconstruction and is, therefore, beneficial in the reconstruction of all types of skin damage. The authors recruited a panel of eight people: 2 veterans from Iraq and Afghanistan (a-b) presenting old war wounds with no chance to cure these after years of treatments and a myriad of surgical operations; 2 elders (one male and one female, 87 and 89 yrs. old, respectively, c-d) presenting severe bedsores; 2 older ladies (e-f) who, in the past, underwent unsuccessful aesthetical operations, presenting puckers, seams, furrows and deep wrinkles; 2 girls (two ex-prostitutes, one black and one white, g-h) who were scarred with a razor by their enemies.