bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluating the impact of local alcohol licensing decisions on outcomes for the community: a systematic review
Authors: Blank Lindsay , Hock Emma , Clowes Mark , Rogerson Marie , Goyder Elizabeth
Published: January 2024

Background

International evidence reviews suggest that reducing the availability of alcohol positively impacts both levels of alcohol consumption and associated harms. To understand the impact of recent changes to alcohol licensing and public health in the UK, this review aimed to identify and synthesise quantitative research evidence on the impact of local alcohol licensing decisions on the health and well-being of the community.

Methods

We searched peer-reviewed articles and grey literature for UK studies. We extracted and tabulated key data from the included papers and appraised study quality. We included topic expert and public consultation to confirm the scope of the evidence synthesis and suggest evidence for inclusion. We synthesised narratively and made recommendations based on our findings.

Results

We identified a small volume (seven papers) of evidence regarding the health (and related) impacts of local alcohol licensing decision undertaken in the UK local authorities. The evidence we identified did not demonstrate a consistent or sustained association between local interventions and health or crime outcomes downstream. This was despite relatively sophisticated study designs using a range of available data sources and some longer-term analysis.

Conclusion

Given that the impacts of local licensing decisions are currently limited, greater regulatory powers are needed if local licensing interventions are to be an effective public health interventions to reduce alcohol-related harms.
On the four-quark operator matrix elements for the lifetime of $$\Lambda _{b}$$
Authors: Zhao Zhen-Xing , Sun Xiao-Yu , Zhang Fu-Wei , Xing Zhi-Peng
Published: January 2024

Heavy quark expansion can nicely explain the lifetime of $$\Lambda _{b}$$

Λ
b

. However, there still exist sizable uncertainties from the four-quark operator matrix elements of $$\Lambda _{b}$$

Λ
b

in $$1/m_{b}^{3}$$

1
/

m

b

3

corrections, which describe the spectator effects. In this work, these four-quark operator matrix elements are investigated using full QCD sum rules for the first time. At the QCD level, contributions from up to dimension-6 four-quark operators are considered. Our method for calculating high-dimensional operator matrix elements holds promise for use in resolving the $$\Omega _{c}$$

Ω
c

lifetime puzzle.
Quantum-enhanced screened dark energy detection
Authors: Hartley Daniel , Käding Christian , Howl Richard , Fuentes Ivette
Published: January 2024

We propose an experiment based on a Bose–Einstein condensate interferometer for strongly constraining fifth-force models. Additional scalar fields from modified gravity or higher dimensional theories may account for dark energy and the accelerating expansion of the Universe. These theories have led to proposed screening mechanisms to fit within the tight experimental bounds on fifth-force searches. We show that our proposed experiment would greatly improve the existing constraints on these screening models by many orders of magnitude.
$$\varvec{J/\psi }$$ decays into $$\omega (\phi ) f_1(1285)$$ and $$\omega (\phi ) ``f_1(1420)$$”
Authors: Lin Jia-Xin , Li Jia-Ting , Liang Wei-Hong , Chen Hua-Xing , Oset Eulogio
Published: January 2024

We perform a theoretical study of the$$J/\psi \rightarrow \omega (\phi ) K^* \bar{K} + c.c. \rightarrow \omega (\phi ) K^0 \pi ^+ K^-$$J/ψ→ω(ϕ)K∗K¯+c.c.→ω(ϕ)K0π+K-reactions with the assumption that the$$f_1(1285)$$f1(1285)is dynamically generated from a single channel$$K^* \bar{K} + c.c$$K∗K¯+c.cinteraction in the chiral unitary approach. Two peaks in the$$K^0 \pi ^+ K^-$$K0π+K-invariant mass distribution are observed, one clear peak locates at the$$f_1(1285)$$f1(1285)nominal mass, the other peak locates at around$$1420 \text {MeV}$$1420MeVwith about$$70 \text {MeV}$$70MeVwidth. We conclude that the former peak is associated with the$$f_1(1285)$$f1(1285)and the latter peak is not a genuine resonance but a manifestation of the kinematic effect in the higher energy region caused by the$$K^* \bar{K} + c.c.$$K∗K¯+c.c.decay mode of the$$f_1(1285)$$f1(1285).
A Statistical Model-Based Approach for Reproducing Intermittent Faults in Electrical Connectors under Varying Vibration Loading Conditions
Authors: Zhou Xinglong , Ye Kuntao , Li Sheng , Liu Songhua
Published: January 2024

The performance of electrical connectors can be significantly impacted by periodic variations in contact resistance caused by vibrational stress. Intermittent faults resulting from such stress are characterized by their random and fleeting nature, making it difficult to study and replicate them. This paper proposes a novel method for reproducing intermittent faults in electrical connectors. To implement this method, intermittent fault data are first collected from electrical connectors subjected to different vibration loads. Next, a statistical distribution model is constructed using kernel density estimation (KDE). Based on this model, a fault injector is designed to simulate intermittent faults under varying vibration loads. The simulated faults are then compared to real-world intermittent fault signals in a controlled environment to validate the accuracy of the method. The results demonstrate that the proposed method effectively reproduces intermittent faults in electrical connectors under varying vibration conditions. This approach can be used to better understand the behavior of connectors under vibrational stress and to develop more effective testing and fault diagnosis methods.
Cretaceous large igneous provinces: from volcanic formation to environmental catastrophes and biological crises
Authors: Percival L. M. E. , Matsumoto H. , Callegaro S. , Erba E. , Kerr A. C. , Mutterlose J. , Suzuki K.
Published: January 2024

The Cretaceous Period was marked by the formation of numerous large igneous provinces (LIPs), several of which were associated with geologically rapid climate, environmental and biosphere perturbations, including the early Aptian and latest Cenomanian oceanic anoxic events (OAEs 1a and 2, respectively). In most cases, magmatic CO
2
emissions are thought to have been the major driver of climate and biosphere degradation. This work summarizes the relationships between Cretaceous LIPs and environmental perturbations, focusing on how volcanism caused climate warming during OAE 1a using osmium-isotope and mercury concentration data. The new results support magmatic CO
2
output from submarine LIP activity as the primary trigger of climate warming and biosphere stress before/during OAE 1a. This submarine volcanic trigger of OAE 1a (and OAE 2), two of the most climatically/biotically severe Cretaceous events, highlights the capacity of oceanic LIPs to impact Earth's environment as profoundly as many continental provinces. Cretaceous magmatism (and likely output of CO
2
and trace-metal micronutrients) was apparently most intense during those OAEs; further studies are needed to better constrain the eruption histories of those oceanic plateaus. Another open question is why the Cretaceous Period overall featured a higher rate of magmatic activity and LIP formation compared with before and afterwards.
When Force Met Fluorescence: Single-Molecule Manipulation and Visualization of Protein–DNA Interactions
Authors: Chua Gabriella N.L. , Liu Shixin
Published: January 2024

Myriad DNA-binding proteins undergo dynamic assembly, translocation, and conformational changes while on DNA or alter the physical configuration of the DNA substrate to control its metabolism. It is now possible to directly observe these activities—often central to the protein function—thanks to the advent of single-molecule fluorescence- and force-based techniques. In particular, the integration of fluorescence detection and force manipulation has unlocked multidimensional measurements of protein–DNA interactions and yielded unprecedented mechanistic insights into the biomolecular processes that orchestrate cellular life. In this review, we first introduce the different experimental geometries developed for single-molecule correlative force and fluorescence microscopy, with a focus on optical tweezers as the manipulation technique. We then describe the utility of these integrative platforms for imaging protein dynamics on DNA and chromatin, as well as their unique capabilities in generating complex DNA configurations and uncovering force-dependent protein behaviors. Finally, we give a perspective on the future directions of this emerging research field.
Medium- and Long-Chain Triacylglycerol: Preparation, Health Benefits, and Food Utilization
Authors: Cheng Xinyi , Jiang Chenyu , Jin Jun , Jin Qingzhe , Akoh Casimir C. , Wei Wei , Wang Xingguo
Published: January 2024

Medium- and long-chain triacylglycerol (MLCT) is a structured lipid with both medium- and long-chain fatty acids in one triacylglycerol molecule. Compared with long-chain triacylglycerol (LCT), which is mainly present in common edible oils, and the physical blend of medium-chain triacylglycerol with LCT (MCT/LCT), MLCT has different physicochemical properties, metabolic characteristics, and nutritional values. In this article, the recent advances in the use of MLCT in food formulations are reviewed. The natural sources and preparation of MLCT are discussed. A comprehensive summary of MLCT digestion, absorption, transport, and oxidation is provided as well as its health benefits, including reducing the risk of overweight, hypolipidemic and hypoglycemic effects, etc. The potential MLCT uses in food formulations, such as infant formulas, healthy foods for weight loss, and sports foods, are summarized. Finally, the current safety assessment and regulatory status of MLCT in food formulations are reviewed.
Chromium Oxide-Ruthenium Oxide Solid Solution Anode Implemented in a Solid Phosphate Electrolyzer at 240 °C and 28 Bar Overpressure
Authors: Bannert F. , Christensen E. , Berg R. W. , Köhler K. , Bjerrum N. J.
Published: January 2024

This work offers an overview of the synthesis and implementation of various chromium-ruthenium oxide materials for gas-phase solid-acid water electrolysis under hydrothermal conditions (240 °C, 28 bar of Ar and steam overpressure). The oxidic solid solutions show general stability over a broad chromium concentration range in the RuO2 rutile structure during synthesis. Decomposition of the solid solutions is observed over a potential of around 2.1 V during electrolysis (including the Ohmic contribution of the setup and cell). Electrolysis performed below this decomposition potential shows promising results for replacing pure RuO2 with a low ruthenium-containing anode. Special attention has been given to Cr0.6Ru0.4O2 for being less expensive because of the lower ruthenium content and showing good stability and comparable performance to RuO2 during continuous chronopotentiometry operation for 1 h at 75 mA cm−2 current densities.
Ascending aortic impedance in young endurance athletes: a time-resolved phase-contrast MRI study
Authors: Fukuie Marina , Yamabe Takayuki , Kimura Ryota , Zhu David C. , Ohyama-Byun Keigo , Maeda Seiji , Sugawara Jun , Tarumi Takashi
Published: January 2024

This is the first study to investigate aortic impedance with the noninvasive, simultaneous recordings of aortic pressure using SphygmoCor XCEL and flow using phase-contrast MRI. We found that the characteristic impedance (Zc) is significantly lower in endurance athletes than sedentary adults, is the strongest predictor of stroke volume (SV), and is inversely associated with aortic compliance. These findings suggest that aortic impedance is a key determinant of the ventricular-vascular coupling adapted to long-term training in endurance athletes.
Probabilistic-Mechanistic Evaluation of a Hybrid Drying System Using l1 Norm Regularisation: Simultaneous Ohmic Heating and Convection Drying
Authors: Turgut Sebahattin Serhat , Kucukoner Erdogan , Karacabey Erkan , Feyissa Aberham Hailu
Published: January 2024

Ohmic-assisted drying (OAD) is a novel drying system that combines ohmic heating and convection drying simultaneously. The present study is aimed at evaluating the mechanism of OAD system behaviours against the combined impact of operational and model uncertainties. Moreover, the dynamic (time-dependent), as well as static (end-of-drying) spatial homogeneity of the model predictions, was quantitatively described for the first time in the literature using Buzas and Gibson’s evenness value (an α-diversity index). The Monte Carlo simulation approach was used to propagate the uncertainty of randomly selected input variables using the Halton sequence sampling method. Mechanistic models include input uncertainties that lead to deviations in model estimations. Both time-dependent and independent global sensitivity of moisture, sample temperature, sample’s internal pressure, their spatial homogeneity, and drying time were assessed using Lasso regression (a variable selection method that penalises the coefficients using l1 norm). The stochastic results of the mechanistic investigation showed that the effects of the input variables are almost identical both as static and time-dependent variables. Lasso regression results indicated that operational and model uncertainties cause varying changes in the magnitude and direction of the stochastic model predictions throughout the process. By contrast, the homogeneity properties of the dry product are not caused by these variations and heterogeneous distribution of the electric field. Additionally, electrical conductivity, oven temperature, applied voltage, and initial moisture were found to be the variables which have the most significant effect on all the variables which were examined in terms of operational and model uncertainties. Practical Applications. The present study investigates the stochastic behaviour of the OAD system through the mechanistic model and using a probabilistic modelling approach. To the best of our knowledge, in addition to being the first study to probabilistically evaluate the OAD system, we are introducing Buzas and Gibson’s evenness value for the first time in the food science/technology literature. This measure serves as a numerical indicator of the spatial distribution homogeneity of the physical properties of the sample. The study’s findings and proposed methodologies will have further applications not only for researchers but also for manufacturers, particularly for those involved in the design and analysis of new drying and food systems in general. Moreover, the presented methods and novel homogeneity measures are generic tools; they can be easily adapted to other process improvement practices involving input/output uncertainty/variability.
Secant Kumaraswamy Family of Distributions: Properties, Regression Model, and Applications
Authors: Nanga Salifu , Sayibu Shei Baba , Angbing Irene Dekomwine , Alhassan Mubarika , Benson Abdul-Majeed , Abubakari Abdul Ghaniyyu , Nasiru Suleman
Published: January 2024

In this study, Secant Kumaraswamy family of distributions is proposed and studied. This is motivated by the fact that no one distribution can model all types of data from different fields. Therefore, there is the need to develop distributions with desirable properties and flexible enough for modelling data exhibiting different characteristics. Some properties of the new family of distributions, including the quantile function, moments, moment generating function, and mean residual life function, are derived. Five special cases of the family of distributions are presented, and their flexibility is shown by the varying degrees of skewness and kurtosis and nonmonotonic hazard rates. The maximum likelihood estimation method is used to obtain estimators of the family of distributions. Two location-scale regression models are developed for the Secant Kumaraswamy Weibull distribution, which is a special case of the family of distributions. Six different real datasets are used to demonstrate the usefulness of the family of distributions and the regression models. The results show that the family of distributions can be used to model real datasets.
Facts and Hopes in Using Omics to Advance Combined Immunotherapy Strategies
Authors: Augustin Ryan C. , Cai Wesley L. , Luke Jason J. , Bao Riyue
Published: January 2024

The field of oncology has been transformed by immune checkpoint inhibitors (ICI) and other immune-based agents; however, many patients do not receive a durable benefit. While biomarker assessments from pivotal ICI trials have uncovered certain mechanisms of resistance, results thus far have only scraped the surface. Mechanisms of resistance are as complex as the tumor microenvironment (TME) itself, and the development of effective therapeutic strategies will only be possible by building accurate models of the tumor-immune interface. With advancement of multi-omic technologies, high-resolution characterization of the TME is now possible. In addition to sequencing of bulk tumor, single-cell transcriptomic, proteomic, and epigenomic data as well as T-cell receptor profiling can now be simultaneously measured and compared between responders and nonresponders to ICI. Spatial sequencing and imaging platforms have further expanded the dimensionality of existing technologies. Rapid advancements in computation and data sharing strategies enable development of biologically interpretable machine learning models to integrate data from high-resolution, multi-omic platforms. These models catalyze the identification of resistance mechanisms and predictors of benefit in ICI-treated patients, providing scientific foundation for novel clinical trials. Moving forward, we propose a framework by which in silico screening, functional validation, and clinical trial biomarker assessment can be used for the advancement of combined immunotherapy strategies.
Supplementary Figure S3 from FASN Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer
Authors: Dairo Oluwademilade , DePaula Oliveira Lia , Schaffer Ethan , Vidotto Thiago , Mendes Adrianna A. , Lu Jiayun , Huynh Sophie Vo , Hicks Jessica , Sowalsky Adam G. , De Marzo Angelo M. , Joshu Corrine E. , Hanratty Brian , Sfanos Karen S. , Isaacs William B. , Haffner Michael C. , Lotan Tamara L.
Published: January 2024

FASN gene expression is upregulated and FASN gene is
hypomethylated in primary prostate tumors from the TCGA primary tumor cohort.
Supplementary Figure S1 from FASN Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer
Authors: Dairo Oluwademilade , DePaula Oliveira Lia , Schaffer Ethan , Vidotto Thiago , Mendes Adrianna A. , Lu Jiayun , Huynh Sophie Vo , Hicks Jessica , Sowalsky Adam G. , De Marzo Angelo M. , Joshu Corrine E. , Hanratty Brian , Sfanos Karen S. , Isaacs William B. , Haffner Michael C. , Lotan Tamara L.
Published: January 2024

Validation of FASN immunostaining assay in genetically characterized
cancer cell lines.
Meckel’s Diverticulum in Adult Geese (Alopochen egyptiacus): A Comprehensive Study of Structure Using Histological, Electron Microscopy, and Immunohistochemical Methods
Authors: Abdel-maksoud Fatma M. , Ali Shimaa , Abd-Elhafeez Hanan H. , Abdalla Kamal E.H.
Published: January 2024

Introduction: The intestine plays an important role in mediating between the bird and its nutritional environment. The yolk stalk, also known as Meckel’s diverticulum, is a landmark between the jejunum and ileum. This work aimed to investigate the anatomical, histological, and electron microscopical features of cellular components of the Meckel’s diverticulum (MD) in adult geese. Methods: The intestine was dissected from the bird’s body cavity, and Meckel’s diverticulum was exposed and prepared for light and electron microscopical examinations. Results: Our results revealed that the MD mucosa is thrown up into villi and crypts, and the mucosal epithelium is a columnar epithelium with goblet cells as well as intraepithelial lymphocytes. Lymphoid follicles and numerous immune cells were demonstrated within the lamina propria. The mucous glands were also observed within the lamina propria and among the lymphoid follicles. The lining epithelium of MD appeared with different staining affinities: dark cells (electron-dense) and light cells (electron-lucent) contained few mitochondria and more secretory vesicles, while dark cells contained more mitochondria and fewer secretory vesicles. Immunohistochemical analysis of MD revealed positive immunoreactivity for several markers, such as CD117, chromogranin, PLCβ, cytokeratin, MHC II, and S100. Conclusion: Taken together, our findings suggest that MD is considered an immune organ in adult geese.
Morpho-Anatomical, Ex-situ Conservation and Haemolytic Activity of Pentaphragma grandiflorum Kurz.
Authors: Amoroso Victor , Aser Cristine Mea , Lalaine Grace M. Maghanoy
Published: January 2024

Pentaphragma grandiflorum Kurz. is one of the five (5) species of Pentaphragma that is found in the Philippines. It is an edible flowering plant consumed as a vegetables and utilized for its medicinal value by the locals. It is categorized as one of the Other Threatened Species with a high economic value. Despite the many uses of P. grandiflorum, there is still inadequate information on its morpho-anatomical characteristics conservation and lack of scientific evidence to support the claim of its safe utilization by the locals. The collected wildlings of the P. grandiflorum were nurtured and monitored in the canopy greenhouse of Central Mindanao University, Philippines. The safe utilization of the leaf extract of P. grandiflorum was assessed through a haemolytic assay. The following are the morpho-anatomical features described in this study: fleshy erect shrub with primary and aerial roots; stem puberulous at a young stage and glabrous upon maturity with dictyostele type of stele; petiole fleshy, puberulous, dissected vascular bundle with dictyostele arrangement; leaf finely puberulous adaxial and glabrous abaxial, dictyostele arrangement, midrib amphibrical arrangement, with tri- to tetracytic stomates; inflorescence arises singly in axil, bisexual, elongated, with yellow and/or purple corolla. Fifty-three out of 130 wildlings survived and abundantly produced bisexual flowers in the succeeding months. The 1 mg/mL concentration of ethanolic and methanolic leaf extracts of P. grandiflorum were found to have an average haemolysis percentage of 0.32 ± 6.78 and 0.45 ± 0.65, respectively. The result of the haemolysis assay revealed that the ethanolic and methanolic leaf extract of P. grandiflorum is safe to utilize and do not pose any toxic effects to humans.
Competition Assessment on Various Intercropping Patterns of Bitter Melon (Momordica charantia L) and Tomato (Solanum lycopersicum L)
Authors: Blessya Christabel Putik , Karyawati Anna Satyana
Published: January 2024

Intercropping is the practice of growing two or more crops in close proximity. Intercropping is useful for obtaining land efficiency, nutrient efficiency, and increasing biodiversity, which is in line with controlling plant-disturbing organisms. Intercropping can also be done in the rice fields, and it is hoped that the optimization of the use of the rice fields will have a good impact on rice and other crops. The adverse effect that is feared to arise due to the intercropping method is the contamination of substances through horizontal transfer of substances between plants. This study was conducted to determine the effect of competition on bitter melon and tomato intercropping. The study started from January to May 2022 in Sukorejo Village, Gondanglegi District, Malang Regency. The research stages include planting and maintaining commodities, observing growth, and organoleptic testing. The study used a Randomized Block Design (RBD) which was arranged in a non-factorial. The total treatment was 5 treatments which were repeated 4 times. The results of the research on the competitiveness of tomatoes were superior to bitter melon in a 2-line and 3-row intercropping system. From an economic point of view, intercropping in a 1:1 or 1:2 ratio is feasible because it has an R/C Ratio of more than 1. Bitter melon and tomatoes grown in polyculture with a 3-row alternate cropping pattern in a 1:2 ratio of tomatoes and bitter melon are feasible because has an R/C Ratio of 3.57 and has a more stable price for bitter melon.
Un Panorama de la historieta del siglo XXI en el Uruguay
Authors: López María Victoria Saibene
Published: January 2024

Relata el desarrollo de las historietas en el Uruguay desde su origen hasta las primeras décadas del siglo XXI. Destaca los principales autores, personajes y factos que influyeran en el actual panorama editorial. Enfoca el papel de los Fondos Concursables, programa gubernamental par incentivo a la producción cultural, creados en el inicio de los años 2000, como impulsador de la industria historietística en el país. Pone especial énfasis en historietas de temática histórica y enfatiza la contribución decisiva del evento Montevideo Comics en la divulgación y valorización de las historietas. Destaca la importancia de la Asociación Uruguaya de Creadores de Historietas (AUCH).
Editorial revista 9a Arte, volume 11, 2023
Authors: Vergueiro Waldomiro , Santos Roberto Elísio dos
Published: January 2024

Editorial para o volume 11 da revista 9a Arte, publicado em 2023.
“Quero enxergar um pouco mais”: atividades e contexto de trabalho do agente socioeducador
Authors: Monteiro Janine Kieling , Tessaro Luiz Gustavo Santos , Guerin Marina , Marin Angela Helena
Published: January 2024

As medidas socioeducativas visam à responsabilização de adolescentes quanto às consequências de atos infracionais cometidos, incluindo sua integração social e privação de liberdade ou restrição de direitos. Os agentes socioeducadores (AS) têm o papel educativo de desenvolver ações que contribuam para ressocialização e manutenção de direitos destes adolescentes e assegurar defesa e proteção social. Objetivou-se avaliar quais são as atividades de socioeducação e segurança desempenhadas por AS e que fatores do seu contexto laboral favorecem ou dificultam a realização do seu trabalho. Foi realizado estudo qualitativo, no qual foram entrevistados 13 AS, de uma instituição na Região Sul do Brasil. Os resultados indicaram que as atividades de socioeducação são feitas de modo mais informal e pontuais, conforme visão de mundo do AS, com foco nos vínculos interpessoais. As de segurança envolvem ações para garantir a salvaguarda das pessoas que circulavam na instituição: contenção física, evitação da violência e vigilância. Conclui-se que os AS necessitam de um programa de educação permanente que permita qualificar as atividades de socioeducação, e que no trabalho seja considerado maior protagonismo deles.
Ouçam Mirtes, mãe de Miguel: precarização e resistência no emprego doméstico durante a pandemia
Authors: Kind Luciana , Furst Brunna Rezende , Gálvez Camila Garro , Ramos Natália Almeida
Published: January 2024

Este artigo é fruto de pesquisa de iniciação científica da PUC Minas sobre trabalho doméstico e pandemia. Em junho de 2020, morreu Miguel, de cinco anos, filho da empregada doméstica Mirtes Renata, que trabalhava durante a pandemia de covid-19. Miguel caiu do edifício enquanto estava sob os cuidados da patroa de Mirtes. A partir do estudo de caso do “caso Miguel”, aliado à bibliografia sobre trabalhadoras domésticas e relações étnico-raciais, buscou-se: (1) observar as relações entre raça, classe e gênero e a naturalização da precarização deste trabalho; (2) analisar o caso Miguel em sua relação com a profissão e movimentos de resistência na luta por direitos, reconhecimento e justiça. Como resultados, observa-se a potência das mobilizações de coalizão entre movimentos sociais e redes de solidariedade para a identificação do caráter estrutural do fenômeno, atuando em forma ampla pela justiça e transformação dessas estruturas. Conclui-se que a pandemia de covid-19 evidenciou a linha direta entre precarização da profissão e a desvalorização das vidas das trabalhadoras domésticas, sendo a morte de Miguel uma consequência da violência e precarização histórica do lugar da mulher negra.
Trabalho, desemprego e condições de saúde: experiências de pessoas egressas do sistema prisional
Authors: Máximo Thaís Augusta Cunha de Oliveira , Barros Vanessa Andrade de , Lhuilier Dominique
Published: January 2024

Estudos apontam o crescimento dos agravos na saúde de pessoas em situações de desemprego, sobretudo na saúde psíquica. Apesar dessa constatação, são escassos os trabalhos que abordam a relação entre desemprego e saúde em grupos marginalizados, como o de egressos(as) do sistema prisional. Tendo em vista essa escassez, este artigo busca conhecer os impactos do desemprego nas condições de saúde dessas pessoas e as formas de manejo que lançam mão para resistir e sobreviver em situações adversas, produzindo saúde. A pesquisa foi realizada por meio de entrevistas com 25 egressos(as) do sistema prisional no Nordeste do Brasil, orientada pelos referenciais teórico metodológicos da Ergologia, da Psicossociologia do Trabalho e pela concepção de saúde de Georges Canguilhem. Os resultados apontam a saúde e o trabalho como recursos e como objetivos dessas pessoas, no entanto, as exigências de adaptação ao cárcere levam à incorporação da cultura prisional, o que retira a capacidade de ser normativo(a), lançando esses(as) egressos(as) em uma situação de dependência incompatível com a produção de saúde. Tal contexto é agravado pela dificuldade de inserção em atividade remunerada e pela saúde já degradada. No trabalho, esperam produzir saúde e reconstruir a vida.
Schizosthetus Athias-Henriot, 1982 (Mesostigmata: Parasitidae): the description of a new species from China
Authors: ZHANG SHUO , XIE LIXIA , WANG HAORAN , DONG MINGHANG , YAN YI
Published: January 2024

A new species, Schizosthetus baixuelii sp. nov., is described based on females from Ningxia Hui Autonomous Region, China. A key to the known species of the genus is presented.
Interpretable convolutional neural network for analyzing precipitation in the pre-rainy season of South China
Authors: Liu Shengjun , Yan Wenjie , Liu Xinru , Hu Yamin , Yang Dangfu
Published: January 2024

The research and application of convolutional neural networks (CNNs) on statistical downscaling have been hampered by the fact that deep learning is highly dependent on sample size and is considered to be a black-box model. Therefore, a CNN model with transfer learning (CNN-TL) is proposed to study the pre-rainy season precipitation of South China. First, an augmented monthly dataset is created by sliding a fixed-length window over the daily circulation field and precipitation data for the entire year. Next, a base CNN network is pretrained on the augmented dataset, and then the network parameters are tuned on the actual monthly dataset from South China. Finally, guided backpropagation is conducted to obtain the distribution regions of the key features and explain the net. The coefficient of determination (R2) and root mean square error (RMSE) show that the CNN-TL model has higher explanatory power and better fitting performance than the feature extraction-based random forest (RF). Compared with the base CNN, the transfer learning approach can improve the explanatory power of the model by 10.29% and reduce the average RMSE by 6.82%. In addition, the interpretation results of the model show that the critical regions are primarily South China and its surrounding areas, including the Indochinese Peninsula, the Bay of Bengal, and the South China Sea. Furthermore, the ablation experiments and composite analysis illustrate that these regions are very important.
Four-decades evolutionary development of municipal solid waste management in China: Implications for sustainable waste management and circular economy
Authors: Yu Tianxu , Liao Chenglin , Stanisavljevic Nemanja , Li Lei , Peng Xuya , Gao Xiaofeng , Yue Dongbei , Wang Xiaoming
Published: January 2024

This study collected data on waste generation and management in China between 1979 and 2020 from government statistics and literature and reviewed the development of municipal solid waste (MSW) management in China. The extended stochastic impact by regression on population, affluence and technology (STIRPAT) model was employed to identify the driving forces of MSW generation, and the cointegration analysis showed that economy (0.35, t = −3.47), industrial structure (3.34, t = −20.77) and urbanization (−1.5, t = 5.678) were the significant socioeconomic driving forces in the long run. By employing the framework of evolutionary economics, this study then investigated the internal rules of long-term interaction between socioeconomic factors and MSW management. The results indicate that, in the long run, MSW management development can be viewed as an evolutionary process that includes a continuous adaptation to external socioeconomic factors and the co-evolution of internal institutions and technologies. Adaptation and diversity of institutions and technologies play an important role in achieving sustainable waste management and circular economy (CE). This study offers a novel evolutionary perspective for explaining dynamic changes of MSW management in China, as well as recommendations for emerging economies to achieve sustainable waste management and CE goals.
I Don’t Deserve COVID-19. The Role of Belief in Just World in Eliminating Negative Effects of Conspiracy Theories Belief
Authors: Fanggidae Jappy P. , Tuati Nonce F. , Samadara Pieter D. , Ismoyo Thomas U.
Published: January 2024

This study examines whether belief in just world manages to reduce the negative impacts of conspiracy theories belief on social distancing intention and vaccination attitude. We also examine the mediating effect of perceived COVID-19 threat in these relations. Using a sample of 262 adult participants from Indonesia, results suggest that when people have high belief in just world, they have a more positive attitude towards vaccination and willingness to practice social distancing even though when they believe in conspiracy theories and feel less threatened by COVID-19. Theoretical and practical contributions are discussed in this article.
TLE1 Expression in NUT Carcinoma: A Case Report Highlighting a Potential Diagnostic Pitfall for the Pathologist
Authors: Aziz Sarah J. , Dickson Brendan C. , Lang Pencilla , Zeman Cady E.
Published: January 2024

NUT carcinoma is a rare, aggressive malignancy defined as a carcinoma with a chromosomal rearrangement affecting the nuclear protein in testis ( NUTM1) gene. This small round blue cell tumor classically exhibits focal abrupt keratinization and immunohistochemical positivity for keratin and squamous markers. However, keratinization is not always present and reports of positivity for other markers that may obscure the diagnosis are increasing. It is also noteworthy that gene fusions involving NUTM1 are not restricted to NUT carcinoma. Herein, we report a NUT carcinoma arising in the mediastinum of a male patient in his 40 s with morphological and immunohistochemical overlap with Ewing family sarcoma and poorly differentiated synovial sarcoma given a round cell morphology, diffuse strong immunoreactivity for CD99, and patchy strong immunoreactivity for TLE1. Squamous differentiation by morphology and p40 expression were notably absent in this case. Classification as NUT carcinoma was ultimately possible when the morphological and immunohistochemical findings were considered in the context of a BRD4::NUTM1 gene fusion identified by next-generation sequencing. While the patient initially responded to palliative radiotherapy, he died approximately one month later. To our knowledge, this is the first report of TLE1 immunoreactivity in NUT carcinoma. This case highlights a potential diagnostic pitfall and emphasizes the need for molecular confirmation in equivocal situations.
Input energy minimization with acoustic potential energy constraint for active noise control system
Authors: Jeong Ikchae , Park Youngjin
Published: January 2024

In this paper, a performance measure of input energy minimization with acoustic potential energy constraint for active noise control (ANC) system was proposed. Making the control area as “quiet zone” can increase the acoustic energy of the remaining area outside the control area, which are undesirable. By reducing the input energy with a reduction loss in the control area, noise increase in the remaining area can be minimized. Conventional input energy minimization measures, degree of controllability (DOC) and degree of disturbance rejectability (DODR) are defined only for systems that satisfy controllability. Most distributed parameter systems, such as ANC systems, cannot satisfy controllability. Therefore, it is impossible to define the input energy measure for an ANC system using existing methods. Here, a new concept of DODR for an ANC system was proposed. This measure has a physical meaning of minimum input energy under the condition that the acoustic potential energy is less than or equal to a desired acoustic potential energy. The DODR measure can be used to select the sensor and actuator combination with the same noise reduction performance in the control area but with the smallest input energy needed. A numerical example shows the usefulness of the proposed measure of DODR for the ANC system.
Acute Hand Injury in Surfing: A Case Report
Authors: Yoshimura Ryo , Kamble Rituja , Dunlop Rebecca , Wormald Justin
Published: January 2024

Hand injuries from surfing tend to be severe and require medical attention. Follow-up of a surfing injury is difficult because many patients are visiting and go home after treatment. We report a case of a surfing hand injury sustained abroad, which was treated upon the patient's return, allowing for follow-up. The mechanism of injury was traction and torsion from the surfboard leash while surfing. The patient was initially treated for nailbed injury but presented later back home after persistent pain, for which an unstable distal phalanx fracture in their right ring finger was found by x-ray. This was surgically reduced with K-wire insertion and nailbed repair. Postoperatively, the injured finger was kept in a splint, and the patient had physiotherapy. Pain was significantly reduced, and the patient regained sufficient function. Considering a fracture as a differential for finger injury caused by the surfboard leash may prevent management delays. Injury may be prevented through education and redesign of the surfboard leash.
The unbearable oldness of generative artificial intelligence: Or the re-making of digital narratives in times of ChatGPT
Authors: Shah Nishant
Published: January 2024

The emerging discourse catalyzed by the opening up of generative artificial intelligence (Gen-AI) applications for everyday usage often presents Gen-AI as radically and disruptively new. I revisit two moments in early conversations in computational history to offer a historicization of Chat GPT: the making of digital narratives through computational methods of storing, sorting and sequencing semantic units and the production of digital narratives through computational architecture of computability and stacks. I offer a framework of critical turns that unpack Gen-AI as a new form of digital narrative practice that challenges the future of meaning and function of narratives in everyday lives.
Analytical modeling of fiber–matrix interface failure in unidirectional laminae subjected to in-plane shear loads
Authors: Vignoli Lucas L. , Carneiro Neto Ranulfo M. , Savi Marcelo A. , Pacheco Pedro M.C.L. , Kalamkarov Alexander L.
Published: January 2024

Unidirectional laminae subjected to in-plane shear loads present complex behavior with strong nonlinear response. A novel analytical model is proposed considering a unit cell with square symmetry and circular fiber cross-section taking into account the failure on the interface between fiber and matrix. The interface failure is a shear-driven phenomenon described by a constant value during the failure process. The model validation is performed using two different approaches: the analytical estimations are compared with experimental data, and finite-element simulations are employed to evaluate the influence of fiber volume fraction. The proposed analytical model captures the main features of experimental data showing its capability and reliability to represent the complex interface debonding propagation phenomenon. Numerical simulations show in-plane shear stress–strain curves for four distinct unidirectional laminae with different fiber volume fractions. Results attest the model capability to describe composite materials with composite failure, essentially characterized by the interface behavior.
Experimental study of lube oil pre-ignition in an optical gas engine test rig
Authors: Vera-Tudela Walter , Süess Pascal , Albrecht Patrick , Wüthrich Silas , Herrmann Kai
Published: January 2024

Lean-premixed gas combustion is an attractive option for meeting future emission standards toward considerably lower particulate matter and emissions while obtaining an efficiency comparable to diesel combustion. However, ignition processes still pose considerable challenges, with pre-ignition being a major issue. The pre-ignition phenomenon might result from the self-ignition of lube oil in hot zones, making it challenging to observe in real engines. To study single or sparsely separated lube oil droplets under engine-like conditions, the “Flex-OeCoS” experimental test facility was used. To be able to induce such pre-ignitions artificially a novel piezo droplet injector was developed and manufactured, which enabled the metering of minor amounts of lubricating oil or even the injection of single droplets. High-speed cameras and specially developed and partially automatable and adaptive evaluation algorithms were used to record and track the behavior of the injected droplet using overlaid schlieren and OH* chemiluminescence. During the measurement campaigns, relevant operating parameters were varied, and optical investigations were carried out with an ignitable mixture on the Flex-OeCoS test facility under engine-relevant operating conditions. Spontaneous ignition of the vaporized lubricating oil was observed, which subsequently led to ignition of the whole air-fuel mixture in the optical combustion chamber. This was especially evident for lean methane-air mixtures up to an air-fuel ratio of 2.0. With this approach, information could be gathered about the necessary internal engine conditions that lead to pre-ignition in lean mixtures and where their limits lie.
Tuning Sodium Channel Blockers to the Near-Atomic Level
Authors: Eyal Sara
Published: January 2024

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Outcome of Flexor Tendon Repair Using Eight-Strand Core Stitch Without Postoperative Finger Splinting
Authors: El-Gammal Tarek Abdalla , Kotb Mohamed Mostafa , Ragheb Yasser Farouk , El-Gammal Yousif Tarek , Anwar Mina Micheal
Published: January 2024

Background:

There are no reports that detail clinical outcomes using the 8-strand suture techniques and early active mobilization. We aim to report the outcome of using an 8-strand double-cruciate core suture followed by early active motion without finger splinting.

Materials and methods:

Thirty-five patients with 41 affected digits were operated and followed up for at least 6 months. A double cruciate repair with 4 single cross-grasping stitches on either side was employed. Active full-range finger flexion/extension exercises were allowed from the third postoperative day with the wrist held in the neutral position.

Results:

The total active motion (TAM) calculated for the proximal interphalangeal and distal interphalangeal joints averaged 151° ± 22°, and the TAM% averaged 86% ± 13%. Based on the original Strickland-Glocovac criteria, excellent and good outcomes were achieved in 25 of 29 fingers (86.2%). An average extension lag of 21° ± 11° (range 10°-40°) was observed in 11 (38%) fingers. The Buck-Gramcko scale showed excellent and good results in 10 (83.4%) thumbs. Active interphalangeal range of motion averaged 68° ± 23°. An average extension lag of 12° ± 4° (range 10°-20°) was observed in 7 (58%) thumbs. Complications occurred in 4 thumbs, including bowstringing (2), rupture (1), and flexion contracture of 60° (1).

Conclusions:

Using the 8-strand repair technique and active mobilization performed by the patient is both practical and cost-saving. Intensive supervision of a hand therapist is generally not required. Notably improved outcomes have been achieved while preventing adhesions at the repair site. Further clinical outcome studies devoted specifically to the flexor pollicis longus are recommended to validate early-phase active mobilization following the 8-strand repair.
Safety and efficacy of the Woven Endo-Bridge-17 device for intracranial aneurysm treatment: A systematic review and meta-analysis
Authors: Ghozy Sherief , Motawei Ahmed Sallam , Moussalem Charbel , Elrefaei Amro , Kobeissi Hassan , Abbas Alzhraa S , Dmytriw Adam A , Kallmes David F , Kadirvel Ramanathan
Published: January 2024

Background

The Woven Endo-Bridge (WEB) device revolutionized the treatment of wide-necked bifurcation aneurysms by intrasaccular flow diversion. The latest advancement is the WEB-17 system, offering greater flexibility with fewer wires, enabling treatment of smaller distal aneurysms using smaller microcatheters than the WEB-21 system.

Methods

We conducted a systematic review following preferred reporting items for systematic reviews and meta-analyses guidelines, analyzing data from seven retrospective cohort studies involving 483 aneurysms treated with the WEB-17 device. Statistical analysis computed pooled prevalence rates and 95% confidence intervals using appropriate models for each outcome and R software version 4.3.1 (R Foundation for Statistical Computing, Vienna, Austria).

Results

Technical success was achieved in 475 out of 483 aneurysms treated with the WEB-17 device, with a success rate of 98.34% (95% confidence interval (CI) = 96.72–99.17). Among the successful cases, 4.97% (95% CI = 1.60–14.39) required adjunctive devices. Adequate occlusion, defined as complete occlusion or neck remnants, was observed in 94.41% (95% CI = 88.17–97.46) of cases. Periprocedural complications were infrequent, with thromboembolic complications occurring in 4.93% (95% CI = 3.29–7.30) of cases, hemorrhagic complications in 1.28% (95% CI = 0.58–2.83), and postprocedural neurologic complications in 0.99% (95% CI = 0.31–3.14). Procedure-related morbidity was observed in 1.71% (95% CI = 0.86–3.39) of cases, and there was one procedure-related mortality reported at 0.21% (95% CI = .03–1.50). Mortality unrelated to the procedure occurred in 1% (95% CI = 0.23–4.15).

Conclusion

Our findings suggest that the WEB-17 device is associated with a high rate of technical success, favorable angiographic outcomes, and a low rate of periprocedural complications. Further research, including prospective trials, is needed to confirm these findings and establish its safety and efficacy definitively.