bluuebunny/crossref_metadata_2025 huggingface dataset:
Il “reato universale”? Una riflessione critica sul ricorso alla extraterritorialità nel sistema penale italiano
Authors: Manacorda Stefano , Colacurci Marco
Published: September 2024

Muovendo dall’emersione, soprattutto nel linguaggio mediatico, del concetto di “reato universale”, il contributo analizza le recenti iniziative adottate dal legislatore interno per proiettare “oltre frontiera” alcuni precetti penali, prevedendo l’applicazione della legge penale a fatti extraterritoriali. In particolare, il riferimento è al decreto-legge n. 20/2023 (c.d. decreto Cutro) e ai progetti di legge in materia di contrasto alla surrogazione di maternità. Tali iniziative denotano la volontà del legislatore italiano di segnalare l’estrema rilevanza attribuita ai beni giuridici sottesi alle norme oggetto di disciplina, rivelando un utilizzo in chiave essenzialmente simbolica ed eticizzante dello strumento penale. Pur rimandando, all’apparenza, ad una dimensione universalistica dei valori in gioco, tali iniziative tralasciano paradossalmente di considerare la categoria dei crimini internazionali, espressione di un’istanza punitiva che dovrebbe rilevare per l’intera comunità degli Stati. Per questa categoria di crimini, il progetto inteso a dar vita ad un codice ad hoc che li includesse nella legislazione interna, in attuazione delle istanze di tutela espresse dallo Statuto della Corte penale internazionale, è stato accantonato. L’analisi del “reato universale” costituisce, dunque, l’occasione per riflettere criticamente su alcune recenti linee politico-criminali e, al contempo, per segnalare il perdurante ritardo nell’adeguarsi ai più elevati standard in materia di giustizia internazionale.
Starting from the emergence, especially in the language of the media, of the concept of "universal crime", the paper analyses the recent attempts made by the Italian lawmaker in order to make certain criminal offences applicable 'beyond the border' to extra-territorial offences. Examples of this trend are the recent Law Decree No. 20/2023 (the so-called Cutro Decree) and the draft laws on combating surrogacy. These initiatives show the intention to underline the importance given to the values protected by the norms, revealing a symbolic and ethical use of criminal law. Although referring to a universalist dimension of the values at stake, the concept of "universal crime" paradoxically neglects the category of international crimes, which notoriously express a punitive instance arising from the entire community of States. The project to adopt an ad hoc code introducing the core crimes in the Italian legislation, according to the Statute of the International Criminal Court, has been abandoned by the lawmaker. Therefore, the analysis of the 'universal crime' is an opportunity to deal with certain criminal policy’s trends arising in the Italian legal order and, at the same time, to point out the persistent delay in adapting it to the highest standards of international justice.
Lo spazio della pena di morte negli Stati Uniti
Authors: Arduini Laura
Published: September 2024

La pena di morte nello scenario degli Stati Uniti rappresenta, tutt'oggi, un tema di grande interesse, considerando che quella statunitense è l’unica democrazia occidentale nella quale permane tale controversa punizione. L'obiettivo del presente contributo è, innanzitutto, quello di fare luce sulla reale ed effettiva operatività della pena capitale nel panorama statunitense; in secondo luogo, quello di comprendere le ragioni della sopravvivenza di tale elemento che è, inequivocabilmente, parte integrante del c.d. American exceptionalism. A questo fine sarà, evidentemente, indispensabile prendere in considerazione il peculiare contesto statunitense: il federalismo, il localismo, nonché altri tropi culturali saranno le stelle polari della nostra indagine. Altrettanto inevitabile sarà esaminare il ruolo che la Corte Suprema federale ha avuto nel definire gli spazi riservati alla pena capitale, nonché l'attuale configurazione della “macchina della morte”.
The death penalty in the scenario of the United States of America represents a topic of great interest today, considering that the U.S. one is the only Western democracy in which this controversial punishment remains. The aim of this contribution is, firstly, to shed light on the real and effective operation of capital punishment in the U.S.; secondly, to understand the reasons for the survival of this element that is, unequivocally, a component of the so-called American exceptionalism. In order to reach the above-mentioned conclusions, it will, evidently, be essential to take into consideration the peculiar U.S. context: federalism, localism, as well as other cultural tropes will be the polar stars of our investigation. Equally inevitable will be an examination of the role that the U.S. Supreme Court has played in defining the spaces reserved for capital punishment, as well as the current configuration of the “machinery of death”.
Il diritto dello spazio extra-atmosferico e le sue fonti
Authors: Redigonda Gabriele
Published: September 2024

Nel breve periodo che intercorre tra il 1967 ed il 1976 sono entrati in vigore i principali trattati volti a regolare le attività svolte nello spazio extra-atmosferico. Nonostante la portata generale dei principi in essi stabiliti, lo sviluppo di nuove tecnologie satellitari e di lancio e la comparsa di nuovi soggetti (in particolare privati) impegnati nello svolgimento di attività spaziali hanno reso evidente la necessità di un’evoluzione del diritto dello spazio. Questo contributo si propone dunque di analizzarne le tendenze evolutive recenti, a partire dall’attenzione riservata allo spazio nel diritto interno e dell’Unione Europea, così come la produzione di numerosi strumenti di soft law a livello internazionale. Un fenomeno che, se da un lato riflette la difficoltà di trovare convergenze in consessi multilaterali al crescere degli interessi nazionali e della polarizzazione delle relazioni tra Stati, dall’altro pare facilitare il rispetto delle norme prodotte da parte degli attori interessati.
During the years between 1967 and 1976 the four main treaties making up the binding regulatory framework for space activities at the international level entered into force. Notwithstanding the forward-looking nature of the principles set by these treaties, the developments of new satellite and launch technologies, as well as the involvement of new actors (especially private) in space activities, raised the need of an evolution of space law. This paper is therefore aimed at outlining recent evolutionary trends, starting from the focus of national and EU law on space and acknowledging the agreement on international soft law instruments and measures. On the one hand, these trends show the difficulty of reaching consensus in multilateral fora around binding rules, in view of growing national interests and the polarisation of international relations; on the other hand, the new instruments would facilitate compliance of space actors with the above-mentioned measures
The Role of Herbals in Complementary and Alternative Cancer Therapies: A Critical Review
Authors: Hamzah Elham F. , AL-Mussawy Ahmed Neema , AL-Azawi Rawaa S. A. , Al-Shukri H.H.K.
Published: September 2024

Background: Cancer patients increasingly seek complementary and alternative therapies (CAM) alongside conventional treatments. Herbals represent a significant component of CAM, with growing interest in their potential anticancer properties. Objective: This review critically examines the role of herbals in cancer management, exploring their mechanisms of action, clinical evidence, potential for synergy with conventional therapies, challenges and perspectives, and patient perspectives. Methods: A comprehensive literature search was conducted using PubMed, Google Scholar, and other relevant databases. Studies investigating the mechanisms, efficacy, safety, and patient experiences with herbals in cancer management were reviewed. Results: Herbals exhibit diverse mechanisms of action, including anti-proliferative, anti-angiogenic, and immune-modulatory effects. Clinical evidence suggests promising results for certain herbals, such as curcumin and ginseng, in improving treatment outcomes and reducing side effects. However, safety concerns and the need for standardization and quality control remain challenges. Conclusion: Herbals hold potential as complementary therapies for cancer management, offering a holistic approach that empowers patients and improves their quality of life. Further research is crucial to optimize their integration with conventional therapies, ensure safety, and establish evidence-based guidelines for their clinical use.
The Role of Productive Zakat on Economic Growth after the Covid-19 Period
Authors: Mas Puan Gustiari , Putra Windhu , Amalia Sisi
Published: September 2024

Zakat is the giving of a portion of one's wealth by an individual. Zakat is obligatory when one's wealth reaches the nisab threshold and the haul period has passed. This study aims to analyze the role of productive zakat in fostering the economic growth of communities affected by the Covid-19 pandemic. Using a qualitative descriptive method, this research indicates that productive zakat significantly influences the efforts and welfare of recipients, as providing business capital enables them to generate income over the long term. As businesses grow, recipients will employ workers to facilitate their operations, which in turn affects the unemployment rate. When individuals have employment and clear income, it impacts their purchasing power, leading to an increase in Gross Domestic Product growth.
Clinician’s Perspectives on the Management of Gastroesophageal Reflux Disease and Prescription Practice of Proton Pump Inhibitors in Indian Settings
Authors: S Manjula , M Krishna Kumar
Published: September 2024

Objective: To assess the clinicians’ perspectives on GERD management and the prescription practices of proton pump inhibitors (PPIs) in Indian settings. Methods: This cross-sectional study was conducted among clinicians specialized in GERD management. Participants completed a 24-question questionnaire distributed via email or online platforms. The survey explored prescription practices, clinical observations, and preferences regarding PPIs and GERD management. Data analysis involved descriptive statistics, with responses presented as frequencies and percentages. Results: Out of 123 survey participants, 57% identified diet as the most common predisposing factor for GERD. Nighttime heartburn and disturbed sleep were recognized as key alarm symptoms by 57% of participants. Epigastric tenderness was the most prevalent physical finding, reported by 68% of clinicians. PPIs were favored as the first-line treatment for GERD by 78.86% of respondents. Domperidone was preferred as an adjunctive treatment for functional dyspepsia and gastroparesis. An empirical PPI trial was widely supported for its simplicity and cost-effectiveness. Rabeprazole emerged as the preferred PPI for nighttime heartburn relief due to its rapid onset and sustained efficacy. Conclusion: This study highlighted a consensus among Indian clinicians on the use of PPIs as a primary treatment for GERD, with a preference for rabeprazole. Domperidone is favored as an adjunctive treatment for functional dyspepsia and gastroparesis. Rabeprazole emerged as the preferred option for nighttime heartburn relief, owing to its rapid onset and long-lasting effectiveness.
Yanayin Halayen Duniya a Wasu Waƙoƙin Adamu Ɗanmaraya Jos
Authors: Alhassan Alhassan
Published: September 2024

Wannan maƙala ta gudana ne a kan wasu waƙoƙin makaɗa Adamu Ɗanmaraya Jos, wanda ya kasance makaɗi ne mai ɗabbaƙa al’adun al’ummarsa da kuma bibiyar yanayin rayuwarsu, da kuma irin yadda suke gudanar da ita a cikin duniya. Manufar wannan takarda ita ce fito da wasu halaye da yanayi na rayuwar duniya a zubin ɗiyan waƙoƙin Alhaji Adamu Ɗanmaraya Jos. A yawancin waƙoƙinsa ya kan fito da saƙonni waɗanda suka dace da halayen rayuwar duniya ta nuna yadda zamantakewar al’umma ta ke. Wannan bincike an tsara shi ne bisa ra’in tsarin al’adu, wato, Cultural Schema Theory. An ƙirƙiri wannan ra'in ne a ƙarshen shekarar 1980s, waɗanda suka fara amfani da shi su ne, Naomi Quinn da masanin halayyar ɗan'adam Claudia Strauss. Ra’in ya bayyana cewa ana nazartar zamantakewar rayuwa da tunanin ɗan’adam a maganganunsa ko a cikin adabin da ya samar. Hakan ya sa aka yi amfani da wannan ra’i wajen nazartar tunanin Adamu Ɗanmaraya Jos game da duniya. Nazarin ya kafa hujja daga wasu ɗiyan waƙoƙin makaɗin. Masana sun yi amfani da wannan ra’in wajen binciken tunanin mutane, musamman a fannin adabi irin su Kennedy (1994) da Pedersen (1994) da Houghton (2012) da sauransu. Haka kuma, an nemo misalan waƙoƙin ne daga kafar intanet da amfani da Diwanin Waƙoƙin Baka na Hausa Gusau, (2019). A wannan maƙala an fahimci irin yadda Ɗanmaraya Jos ya fito da halin duniya da yanayin da take sanya mutane, musamman waɗanda suka ruɗu da ita, da kuma irin sauyin da ta ke yi wa mutane na ɗauka da ajiyewa. Har ila yau kuma, mawaƙin ya fayyace irin yadda duniya ta kasance mayaudariya, wadda ba ta da gwani. Haka kuma, an nuna cewa komai na duniya samamme ne kuma ƙararre, saboda haka duk abin da ke cikin duniya yana da lokaci, wata rana zai zama tarihi.
Harmonie Des Langues En Traduction Litteraire: L’art Subtil De La Modulation
Authors: -Abdulrahman Khadijah Ashiru
Published: September 2024

Cette étude est basée sur notre expérience collective d'analyse d'un texte littéraire de l’anglais vers la langue française. L'ouvrage que nous avons analysé est écrit en anglais sous le titre Omokewu et traduit en français sous le titre Étudiant. L’analyse est centrée sur l'observation des sept techniques proposées par Vinay et Dalbernet 1958 en particulier la modulation qui s'avère être l'une des meilleures parmi les techniques de traduction d'une œuvre littéraire. Quelques traducteurs ne savent pas comment et quand utiliser ces techniques de la traduction. Afin d'endiguer ce problème des erreurs de traduction causées par ces traducteurs non professionnels. Certaines théories et principes de traduction ont été examinés. La théorie de J. C Catford (Linguistic theory of translation), Katharina Reiss and Hans Vermeer (skopos theory), de Lawrence Venuti (The translator’s invisibility: A history of translation), de Mona Baker parmi d’autres ont été étudiés. Après avoir examiné les principes et théories, La concept de la modulation dans l’œuvre « Omokewu » a été dûment analysée. En réalisant cette étude, nous avons découvert que la technique de modulation est la meilleure pour la traduction de poésies, de musiques et d'éloges funèbres.
عنوان المقالة: جمالية التكرار في ديوان أستاذ الدكتور سمبو ولي جنيد دراسة بلاغية تحليلية
Authors: Muhammad Dr. Idris Muhammad , Harun Yahaya Muhammad
Published: September 2024

ومن البسيط ما لخصه الباحث من أن التكرار أحد السمات الأسلوبية البلاغية لدى الشاعر, وأنه يدل على الفكرة الرئيسية التي تسيطر على شعوره، لأن الإعادة إرادةَ الإبلاغ بحسب عناية الشاعر والإهتمام. استخدم الشاعر التكرار اللفظي أكثر من تكرار المعنوي وتكرار المترادفات وتكرار جذر الكلمة. ومن أغراض التكرار البارزة في شعر أستاذ الدكتور سمبو ولي جنيد تدور حول نطاق توكيد المعنى يريد إيصالها في نفوس السامعين, والتنويه والإشادة بمكانة الممدوح والحنين الذي يهيمن على قلب الشاعر . أسلوب الشاعر أسلوب سهل من ناحية ألفاظه وتراكيبه سليم من التعقيد اللفظي والمعنوي, كما هو ملتزم بقواعد الشعر من الوزن والقافية, الأمر الذي جعل شعره صالح للبحث والدراسة لإخراج الأسرار اللغوية المتنوعة فيه. وقد غلب في شعره فن الغزل، ثم يليه المدح والرثاء والهجاء والوصف، ثم المناسبات والتوسلات والشكوى والحنين.
Celan / Heidegger
Authors: Bauzá Hugo Francisco
Published: September 2024

El texto evoca el encuentro entre Paul Celan y Martin Heidegger que tuvo lugar el 25 de julio de 1967 que, a pesar de la admiración mutua por la poesía, especialmente la de Hölderlin, estuvo marcado por tensiones no resueltas. En el camino de las interpretaciones de Georg Steiner, Rüdiger Safranski, Ezra Pound, Walter Otto y John Banville, entre otros, esta nota hace converger, a partir de lo que puede suponerse en aquella reunión en la cabaña de la Selva Negra, la relación de Heidegger con su pasado nazi, la experiencia del Holocausto en la vida de Celan, el papel del lenguaje y la nominación y el concepto e importancia del silencio.
AUTOMEDICAÇÃO DURANTE A PANDEMIA: O DISCURSO DOS ACADÊMICOS DE UM CURSO DE ENFERMAGEM
Authors: Monteiro Ana Carolina Irias , Silva Bárbara Maia da , Rosa Cíntia de Souza Silva , Ribeiro Dayane de Souza , Silva Fabiano Júlio Delesposte , Ribeiro Wanderson Alves , Ramos Gabrielle Corrêa , Vicente Larissa da Silva
Published: September 2024

A pandemia causada pelo Coronavírus, gerou inúmeras incertezas e preocupações. Percebeu-se um aumento na compra e consumo de fármacos, ou seja, a automedicação. Este estudo analisou o discurso de acadêmicos de enfermagem sobre a automedicação durante a pandemia do COVID-19. Os objetivos incluíram, além de investigar o discurso dos acadêmicos acerca automedicação, identificar as classes de medicamentos mais utilizadas por eles nesse contexto. A pesquisa quali-quantitativa realizada em uma universidade particular em Volta Redonda/RJ, e incluiu acadêmicos do 1º período ao 5º ano de enfermagem. Foram coletadas respostas por meio de um questionário com perguntas fechadas e abertas. Os resultados revelaram que a automedicação era mais comum entre as mulheres com idades entre 18 e 23 anos. Os principais motivos para a automedicação foram a prevenção e o tratamento de sintomas não relacionados à COVID-19, como cefaleia e resfriado. Analgésicos e anti-inflamatórios foram as classes de medicamentos mais utilizadas. Observou-se que muitos participantes tinham conhecimento dos riscos da automedicação, mas ainda assim a praticavam, com 79,41% admitindo fazê-lo. Concluiu-se que a automedicação era prevalente entre os acadêmicos de enfermagem, o que é consistente com outros estudos realizados. Isso destaca a necessidade de conscientização dos acadêmicos sobre os riscos da automedicação.
Tecnologias Assistivas no cotidiano de pessoas com paralisia cerebral: Uma revisão das inovações e barreiras de acessibilidade.
Authors: Santos Luiz Henrique , Alesandra Camile de Farias Lima  , Alison Gessinger Guedes Morais  , Andréia Carmem Cunha Oliveira  , Anny Kaliny Bezerra Mulatinho  , Fabrizia Bezerra Mulatinho  , João Filho dos Santos Brito  , João Victor Barbosa de Macedo  , João Vinicius Lira da Silva  , Kaíke Lorenz Kalauã dos Santos Lima  , Kaio Guilherme Siqueira de Oliveira  , Luísa Tannus Lima  , Raquel Nery de Lima Sabino  , Renato de Caldas Almino  , Thaise Silveira dos S Apolinario  , Camila Catarina Braz de Albuquerque Pontes Lopes
Published: September 2024

O presente artigo tem por objetivo realizar uma revisão de estudos clínicos recentes sobre a importância do uso de tecnologias assistivas para o cotidiano de pessoas com paralisia cerebral (PC), visando avaliar as inovações e limitações de acessibilidade na vida dos usuários de dispositivos de mobilidade. Por meio do banco de dados PubMed, foi feita a leitura do título e do resumo de 274 artigos e, desses, a seleção de 14, através dos termos específicos “Tecnologias Assistivas e Paralisia cerebral”. Conclui-se que o uso de tecnologias assistivas no cotidiano de pessoas com PC, atentando-se às questões de especificidade de cada paciente, facilita o processo de reabilitação e promove uma percepção maior de autoconfiança, independência e, consequentemente, inclusão social.
O impacto do diagnóstico tardio de TEA em adultos: Desafios clínicos e Implicações para o tratamento
Authors: Santos Luiz Henrique , Alesandra Camile de Farias Lima  , Alison Gessinger Guedes Morais  , Andréia Carmem Cunha Oliveira  , Anny Kaliny Bezerra Mulatinho  , Fabrizia Bezerra Mulatinho  , João Filho dos Santos Brito  , João Victor Barbosa de Macedo  , João Vinicius Lira da Silva  , Kaíke Lorenz Kalauã dos Santos Lima  , Kaio Guilherme Siqueira de Oliveira  , Luísa Tannus Lima  , Raquel Nery de Lima Sabino  , Renato de Caldas Almino  , Thaise Silveira dos Santos Apolinario  , Leonardo Araújo de Oliveira
Published: September 2024

Este artigo tem por objetivo realizar uma varredura da literatura médica vigente sobre o Diagnóstico Tardio de Transtorno do Espectro do Autismo (TEA) em Adultos, visando na melhora da qualidade de vida dos pacientes adultos e na identificação de sinais clínicos, nas quais geram dificuldades sociais, comunicativas e comportamentais que esses enfrentam. Mediante o banco de dados PubMed, foi realizada a leitura do título e do resumo de 186 artigos e, desses, a seleção de 14, por meio dos termos específicos “O Impacto do Diagnóstico Tardio de TEA em Adultos”. Dessa forma, conclui-se que o diagnóstico em adultos é desafiador devido muitos já desenvolveram estratégias compensatórias, nas quais urgem novas abordagens para o tratamento com adaptações personalizadas, voltadas para melhorar a qualidade de vida, promover inclusão social e tratar comorbidades como depressão e ansiedade, sempre ajustando às necessidades específicas da fase adulta.
Como a exposição ao estresse durante a infância impacta o desenvolvimento do vício na idade adulta?
Authors: Fernanda Felix Giordani  , Jhonatan dos Santos Franco  , João Francisco Gonçalez Rossito Cavalcante  , Stella Rezende  , Marília de Melo  , Ana Laura Monteiro de Oliveira  , Camila Lopes Dias Arroyo  , Luana Martins Ferreira  , André Felipe Moresco Ritt  , Gabriele de Oliveira Passos  , Fernanda Machado Maran  , Alanis Belmonte Bergmann
Published: September 2024

A exposição ao estresse durante a infância é amplamente reconhecida como um fator de risco significativo para o desenvolvimento de transtornos psicológicos e comportamentais, incluindo vícios na vida adulta. Este artigo de revisão examina os efeitos do estresse precoce no desenvolvimento cerebral e na vulnerabilidade ao vício, enfatizando a intrincada interação entre o estresse infantil e as alterações neurobiológicas, particularmente no eixo hipotálamo-hipófise-adrenal (HPA) e nas vias de recompensa dopaminérgica, ao mesmo tempo em que considera fatores genéticos e ambientais que podem modular o risco de dependência por meio de interações gene-ambiente. As evidências científicas indicam que o estresse infantil pode causar alterações profundas e duradouras no desenvolvimento do cérebro, particularmente em áreas envolvidas na regulação emocional, no controle de impulsos e na resposta ao estresse. Essas alterações criam um ambiente neurobiológico propício para o desenvolvimento de vícios na idade adulta, ao modificar a funcionalidade do sistema de recompensa e aumentar a vulnerabilidade a substâncias que induzem a liberação de dopamina. A intrincada interação de predisposições genéticas, mecanismos de apoio social, resiliência psicológica e intervenções precoces indica que, embora o estresse infantil aumente a propensão a comportamentos aditivos, tais resultados não são predeterminados, necessitando da identificação e aprimoramento de fatores de proteção para a formulação de estratégias de saúde pública e práticas clínicas destinadas a aliviar os impactos do estresse precoce e promover o desenvolvimento saudável ao longo da vida; consequentemente, uma estratégia abrangente que integre fortes apoio social, terapêutico medidas e iniciativas preventivas podem diminuir significativamente a suscetibilidade de indivíduos enfrentarem adversidades precoces ao vício.
Oxytocin Massage and Infant Massage on the Smooth Flow of Breast Milk
Authors: Purwandari Atik , Korompis Martha , Tuju Sjenny Olga , Wahyuni Wahyuni , Amdadi Zulaeha A
Published: September 2024

The global infant mortality rate remains a cause for concern, with 2.6 million babies worldwide not surviving beyond one month, and one million succumbing at birth, as reported by the United Nations Children's Fund (UNICEF). This study, conducted in North Minahasa district, seeks to address this issue by analyzing the effectiveness of Oxytocin Massage and Baby Massage, coupled with family support, in promoting the smooth production of breast milk. Employing a pre-experimental method with a one-group pre-and-post-test design, the research investigates the impact of Oxytocin Massage and Baby Massage on breastfeeding mothers and the subsequent release of breast milk. The findings, analyzed using Paired T Test, reveal a significant effect of both massages on breast milk production, with a p-value of 0,00. Oxytocin massage proves effective in facilitating breast milk release, as evidenced by the observed reduction in breast tension before breastfeeding (pre 23%, post 93,33%) and an increase in breast milk leakage (pre 23,3%, post 93,3%). Similarly, baby massage demonstrates effectiveness in promoting smooth breast milk release, reflected in increased breastfeeding frequency (pre 43,3%, post 66,7%), higher urination frequency (pre 40%, post 56,7%), and improved post-feeding sleep quality (pre 43,3%, post 96,7%). The study underscores the role of family support in optimizing breast milk flow, advocating for the implementation of Oxytocin Massage for breastfeeding mothers and Baby Massage within the household. This approach holds promise in addressing global infant mortality concerns by fostering healthier breastfeeding practices through accessible and family-centered interventions.
To Study The Role Of Concha Bullosa In The Aetiology Of Deviated Nasal Septum (DNS) And Sinusitis
Authors: manhas Amit
Published: September 2024

AIMS AND OBJECTIVES : To study the role of concha bullosa in the devlopment of deviated nasal septum(DNS) and sinusitis.

MATERIAL METHODS: 235 CT scans of paranasal sinuses done from March 2022 to November2022 were studied and evaluated for the presence of concha bullosa, DNS andsinusitis.

RESULTS: Among 235 CT scans concha bullosa was found in 74(31.4%)patients.Among these patients, concha bullosa coexisting with DNS was found in56(75.7%) patients.Now, among these air column between concha bullosa and theseptum was found in 43 (76.7%) patients.Sinus disease was present in 48(64.8%)patients.

CONCLUSION: Concha bullosa has a strong association with the existence ofconcomitant DNS.However, the presence of air column may exclude the role ofconcha bullosa in the aetiology of DNS. Presence of concha bullosa may predisposeto Sinusitis.

KEYWORDS: concha, DNS, sinusitis,
Covid-19 Anosmia And Gustatory Symptoms As A Prognostic Factor
Authors: Shah Nadir
Published: September 2024

coronavirus pandemic has affected millions of people all across the globe. Along with fever sore throat respiratory difficulty anosmia and ageusia are important symptoms being seen. This study evaluates the prevalence of olfactory and gustatory dysfunction in patients with SARS CoV-2 infection and the severity and duration of altered taste and smell along with time taken for recovery. A total number of 300 patients that had tested positive for COVID 19 in lady hardinge medical college and associated hospitals were assessed for presence and severity of olfactory and gustatory dysfunction.
Reinforcement Learning for Optimizing Test Case Execution in Automated Testing
Authors: Kumar Karne Vinod , Noone Srinivas  , Nagaraj Mandaloju  , Parameshwar Reddy Kothamali
Published: September 2024

This study explores the use of reinforcement learning (RL) techniques to optimize test case execution in automated testing frameworks, addressing the inefficiencies of traditional testing methods. The primary research problem involves enhancing testing efficiency, improving coverage, and reducing redundancy through intelligent RL-based optimization. The study employed a design that integrated RL algorithms into automated testing frameworks, involving the development and training of an RL model, followed by empirical evaluation. ajor findings indicate that RL-based optimization significantly reduced test case execution time, improved test coverage, and minimized redundancy compared to conventional methods. The RL model dynamically adjusted test case sequences based on real-time feedback, leading to enhanced efficiency and more comprehensive testing. The study concludes that RL techniques offer a promising approach to overcoming traditional testing limitations, demonstrating tangible benefits in real-world scenarios. To put in a nutshell, RL-based optimization effectively addresses key challenges in automated testing, offering a more adaptive and efficient strategy for test case execution.
Knowledge Graphs for Personalized Recommendations
Authors: MURALI MOHANA KRISHNA DANDU  , Vishwasrao Salunkhe  , Shashwat Agrawal  , Prof.(Dr) Punit Goel  , Vikhyat Gupta
Published: September 2024

Knowledge graphs have emerged as a transformative tool in enhancing personalized recommendation systems. By integrating diverse datasets into a structured semantic network, knowledge graphs offer a holistic view of relationships and entities that can significantly improve the relevance and accuracy of recommendations. Unlike traditional recommendation algorithms that rely primarily on user behaviour and item similarity, knowledge graphs leverage contextual information and complex interconnections among entities to deliver more nuanced and context-aware suggestions. This abstract explores the pivotal role of knowledge graphs in advancing personalized recommendation systems, focusing on their ability to capture intricate relationships between users, items, and attributes. By mapping out these relationships, knowledge graphs facilitate a deeper understanding of user preferences and item characteristics, enabling the generation of more tailored and precise recommendations. Additionally, the incorporation of external knowledge sources into the graph can further enrich the recommendation process, leading to enhanced user satisfaction and engagement. The paper reviews various methodologies for integrating knowledge graphs into recommendation systems, including graph-based algorithms and machine learning techniques. It also examines real-world applications and case studies where knowledge graphs have demonstrated substantial improvements in recommendation quality. Ultimately, the utilization of knowledge graphs represents a significant leap forward in personalizing user experiences, offering a promising avenue for future research and development in the field of recommendation systems.
Cross Market Monetization Strategies Using Google Mobile Ads
Authors: Archit Joshi  , Rahul Arulkumaran  , Nishit Agarwal  , Anshika Aggarwal  , Prof.(Dr) Punit Goel  , Dr. Alok Gupta
Published: September 2024

In the rapidly evolving digital landscape, effective monetization strategies are crucial for businesses seeking to maximize revenue across diverse markets. This paper explores cross-market monetization strategies utilizing Google Mobile Ads, focusing on how businesses can leverage this platform to optimize their revenue streams. Google Mobile Ads offers a versatile range of tools and solutions designed to target and engage users across different geographical and demographic segments. By employing these tools, businesses can enhance their ad campaigns' effectiveness, ensuring they reach the right audience with relevant content.
The study examines various approaches to integrating Google Mobile Ads into broader monetization frameworks, including localized ad targeting, dynamic ad placements, and performance analytics. Emphasis is placed on the strategic use of data-driven insights to tailor ad content and delivery, thereby increasing user engagement and conversion rates. Additionally, the research highlights best practices for balancing global and local market demands, optimizing ad spend, and improving overall campaign ROI.
Through a comprehensive analysis of case studies and industry examples, this paper provides actionable recommendations for businesses looking to implement cross-market monetization strategies effectively. The findings underscore the importance of leveraging Google Mobile Ads' features to achieve a competitive edge in diverse markets while driving sustainable growth and profitability.
Optimizing Machine Learning Models for Predictive Analytics in Cloud Environments
Authors: Krishna Kishor Tirupati  , Siddhey Mahadik  , Md Abul Khair  , Om Goel  , Prof.(Dr.) Arpit Jain
Published: September 2024

The integration of machine learning (ML) models with cloud computing has transformed the landscape of predictive analytics, offering scalable, efficient, and flexible solutions for organizations. Cloud platforms such as AWS, Google Cloud, and Microsoft Azure enable businesses to deploy and manage complex ML models without the need for extensive on-premise infrastructure. However, optimizing these ML models for performance and cost-efficiency in cloud environments presents unique challenges, including resource management, latency, scalability, and data security.
This paper focuses on strategies to optimize machine learning models specifically for predictive analytics in cloud environments. It explores key techniques such as auto-scaling, model compression, and hyperparameter tuning, which are critical for improving the accuracy and speed of predictions while minimizing computational costs. The research also examines advanced tools such as containerization, serverless computing, and cloud-native services that further streamline the deployment and management of ML models.
In the Indian context, where cloud adoption is growing rapidly, optimizing ML models is crucial for businesses across various sectors, including finance, healthcare, and e-commerce. By leveraging cloud-based ML solutions, Indian companies can enhance their predictive analytics capabilities, driving smarter decision-making and operational efficiency.
This abstract presents an overview of how optimized machine learning models can unlock the full potential of predictive analytics in cloud environments, leading to better business outcomes. Through case studies and practical applications, this paper provides actionable insights into the best practices for optimizing ML models in a cloud-based setting.
IMPACT OF DOUBLE REDUCTION POLICY: INPUT TO MANAGEMENT OF PUPILS’ ACADEMIC PERFORMANCE AND PHYSICAL HEALTH
Authors: DR. WEI XIANJUN  , DR. JANETTE C. MAGALONA
Published: September 2024

The study assessed the academic performance and physical health of grade 4-6 pupils under the Double Reduction Policy as a basis for policy enhancement. This study was conducted to two hundred fifty-five (255) teachers, and three hundred (300) parents for a total of eight hundred fifty-five (855) respondents. The study used descriptive research design.  It utilized mean, SD, t test and Pearson Product moment of Correlation in treating the data. The study revealed that the pupils when grouped according to age, gender, birth order and grade level have moderate level of perception when it comes to the implementation of the double reduction policy, the status of the physical health of the pupils is Fair, their academic performance was Fair, there is a significant difference on the physical health and academic performance of pupils under the double reduction policy management according to age, gender, birth order and grade level, as well as there is a significant relationship in the physical health and academic performance of pupils under the double reduction policy when grouped according to age, gender, birth order, and grade level. The study recommended that the pupils can apportion more time to participate in interests, hobbies, and comprehensive quality development, parents better focus on their children's healthy growth. Teachers can provide flexible teaching activities which can help cultivate students' comprehensive qualities and innovative abilities. Policy makers and the government agencies can promote education system reform to cultivate more innovative and practical talents.
MIXED CROPPING SYSTEM ALONG WITH COCONUT
Authors: Prof. Vasanth Kumar
Published: September 2024

Intercropping structure in coconut cultivation enables environmental resolution regarding enhancement in ecological sustainability and farm performance, specifically for small scale farmers. The paper explored how Intercropping structure enhances farm performance, carbon capture, enduring agricultural output and soil productivity. This study examines the capable harvests like black pepper, banana, legumes and pineapple along with coconut palm in order to utilize the terrain, intercropping enables the agriculturists to expand revenue streams and improve soil quality. It Examines the disputes of administering intercropping structure and requirement for high agriculturists knowledge and primary funding. The researches’ objective is to discover how mixed cropping structure enhances resource effectiveness, aids towards eco friendly environment through biodiversity and carbon capture, this also focuses on reduction of dependence on artificial addictive. The study will highlight the enduring financial and environmental advantages of implementing intercropping in coconut cultivation, placing it as an important technique for eco-friendly farming.
KEY WORDS: Mixed cropping, Coconut Cultivation, Intercropping, Sustainable Agriculture, Soil health, Carbon Capture, Smallholder Farmer, Biodiversity
SZTUCZNA INTELIGENCJA SI W NACZYNIOWEJ CHIRURGII, TERAŹNIEJSZOŚĆ I PRZYSZŁOŚĆ
Authors: Majewski Marek
Published: September 2024

Temat tego wystąpienia pozwoli pokazać ewolucję metod chirurgicznych dającą niesamowite możliwości małoinwazyjnego, precyzyjnego leczenia i tym samym minimalizacji komplikacji. Czy chcemy tego czy nie, świat zmierza w kierunku « intelligence artificielle », co już od dawna widoczne jest w medycynie. W chirurgii naczyniowej nowoczesne technologie generują duże koszty, lecz w ostatecznym rozrachunku ekonomicznym są korzystne. SI odgrywa coraz większą rolę w chirurgii naczyniowej, wspomagając lekarzy i poprawiając wyniki operacji. Może być wykorzystywana w wielu różnych obszarach, takich jak : 1. diagno- zowanie, 2. planowanie operacji, 3. asystowanie podczas zabiegu, 4. monitorowanie pacjenta po operacji, 5. symulacja przedoperacyjne. Podsumowując, SI w chirurgii naczyniowej ma duży potencjał. Przyczynia się: do poprawy wyników operacji, skrócenia czasu rekonwalescencji oraz zwiększenia bezpieczeństwa pacjentów. Jednak zawsze to lekarz jest decydującym czynnikiem. SI pełni jedynie rolę wsparcia i narzędzia pomocniczego.
SZTUCZNA INTELIGENCJA W LECZENIU STOPY CUKRZYCOWEJ
Authors: Jawień Arkadiusz
Published: September 2024

Obserwowany w ostatnich latach gwałtowny wzrost zachorowań na cukrzycę prowadzi nieodłącznie do zwiększonego występowania zespołu stopy cukrzycowej. Pojawiające się niedokrwienne zmiany naczyniowe, w końcowej fazie w formie owrzodzenia i martwicy stopy, obniżają nie tylko jakość życia chorego, ale prowadzą ostatecznie do amputacji kończyny. Ograniczenia obecnych metod wykrywania stopy cukrzycowej i interwencji podkreślają pilną potrzebę innowacyjnych rozwiązań. Kluczem do poprawy tej sytuacji wydaje się coraz częstsze zastosowanie sztucznej inteligencji (Artificial Inteligence – AI). W chwili obecnej, wydaje się, że największe zastosowanie AI w stopie cukrzycowej dotyczy wczesnej diagnostyki, w tym dokładnej analizy zmian ucieplenia stopy za pomocą termografii i stworzenia tzw. „selfie stóp” chorego, pozwalającego na wczesne przewidywanie możliwości pojawiania się powikłań. Innym polem działania AI w stopie cukrzycowej powikłanej owrzodzeniem, są techniki pozwalające na ocenę nie tylko stanu biochemicznego rany, ale i jej oceny mikrobiologicznej. Pojawiające się coraz częściej tzw. inteligentne opatrunki pozwalają na bezpośrednie monitorowanie procesu gojenia się rany i podejmowania decyzji o kolejnych krokach terapeutycznych. Należy jednak pamiętać, że potencjalne, ogromne korzyści płynące z zastosowania i włączenia AI do codziennej praktyki lekarskiej mogą stwarzać wiele wyzwań, poczynając od odpowiedniego przeszkolenia personelu aż do odpowiedzialności prawnej i etycznej korzystania z „dobrodziejstwa” sztucznej inteligencki. Jedno jest pewne, AI wkracza do leczenia stopy cukrzycowej i tylko od mądrości personelu medycznego oraz samych chorych zależeć będą korzyści z jej zastosowania.
DEFINING THE ROLE OF ABI1 GENE IN PROSTATE CANCER PROGRESSION AND TREATMENT RESISTANCE
Authors: Kotula Leszek
Published: September 2024

Introduction: Prostate cancer remains a major challenge worldwide. Anti-androgen pathway inhibitors have evolved from blocking androgen production to targeting the anti-androgen receptor (AR) pathway. However, inhibiting AR’s transcriptional function often leads to treatment resistance. This study identifies a novel mechanism of resistance involving Abelson Interactor 1 (ABI1), an actin regulatory protein, in AR transcriptional regulation. Material and Methods: We examined the correlation between ABI1 and AR in tumor samples from patients undergoing neoadjuvant hormonal therapy (NHT). AR-ChIP binding to ABI1 gene sequences after androgen stimulation established AR-dependent ABI1 mRNA expression. In vitro binding assays, ChIP-seq, and NMR spectroscopy demonstrated ABI1-DNA binding. ABI1-AR binding was determined using immunoprecipitation and proximity ligation assay (PLA). RNA-seq analysis compared ABI1 CRISPR KO with naïve and ABI1-rescued LNCaP cell lines to assess ABI1’s impact on AR transcription.
Results: We found a reciprocal regulatory relationship between ABI1 and AR. ABI1 is directly regulated by androgens and interacts with both AR and its splice variant, ARv7, co-regulating specific transcriptional targets. ABI1’s transcriptional activity involves a defined interaction between its intrinsically disordered region and DNA. Clinical evaluations showed that ABI1-DNA binding and ABI1-AR interaction are tightly regulated during androgen deprivation therapy and prostate cancer progression. This regulation links the actin cytoskeleton, cellular signaling, and transcriptional regulation, suggesting that ABI1 acts as an epigenetic regulator in AR-driven cancers.
Conclusions: Our research reveals a complex network of interactions between ABI1 and AR, highlighting potential innovative therapies targeting transcriptional dysregulation in AR-driven cancers. This understanding opens new avenues for revolutionizing prostate cancer treatment [1].
NAJNOWSZE OSIĄGNIECIA W PIELĘGNACJI ANTI-AGING
Authors: Dębowska Renata
Published: September 2024

Starzenie się skóry jest procesem naturalnym, zachodzącym przy udziale między innymi czynników wewnątrzpochodnych i zewnątrzpochodnych. Są one źródłem powstawania wolnych rodników generujących stres oksydacyjny dla komórek skóry, czego efektem jest zaburzanie funkcjonalności białek, a w konsekwencji DNA oraz lipidów, a w szerszej perspektywie przyspieszanie procesów starzenia się skóry. Produkty kosmetyczne zawierające składniki o wysokim potencjalne regeneracyjnym oraz substancje antyoksydacyjne mogą skutecznie przyczynić się do redukcji symptomów starzenia. FGF (fibroblasts growth factor) jest białkiem będącym komórkowym czynnikiem wzrostu warunkującym procesy proliferacji komórek skóry. Modyfikacje w sekwencji FGF zwiększyły stabilność białka przy jednoczesnym zachowaniu aktywności biologicznej. Została opatentowana technologia mikrosfer lipidowych, umożliwiająca transport dermalny FGF. Synergiczny dobór kosmetycznych składników antyok- sydacyjnych to ważny element prawidłowej pielęgnacji skóry. W badaniach wykazano synergię połączenia tioproliny, ergotioteiny, sylimaryny i kwasu rozmarynowego
o silnym działaniu antyoksydacjnym. Poza substancjami zdolnymi do eliminacji lub ograniczania powstawania wolnych rodników na uwagę zasługują także substancje
o właściwościach cytoprotekcyjnych. Naryngenina zwiększa potencjał błonowy mitochondriów w komórkach skóry. Poprzez aktywację kanałów potasowych staje się silnym cytoprotektantem. Ma także działanie przeciwzapalne.Wśród substancji zasługujących na uwagę wkontekście kuracji wspierającej redukcję oznak starzenia skóry jest także sukralfat, o silnym działaniu regenerującym. Ma właściwości przeciwzapalne i wpływa na procesy wspomagające regenerację skóry. Opracowanie technologii dostarczania sucralfatu do skóry zostało objęte ochroną patentową. Stosowanie w kuracji przeciwstarzeniowej odpowiednio dobranych składników aktywnych pozwala ograniczyć wpływ czynników wewnątrzpochodnych i zewnątrzpochodnych na procesy starzenia się skóry.
ZASTOSOWANIE TERAPII CAR-T W ONKOHEMATOLOGII DZIECIĘCEJ
Authors: Wachowiak Jacek
Published: September 2024

Wdrożenie immunoterapii z zastosowaniem autologicznych limfocytów T z chimerycznym receptorem antygenowym (CAR-T) stało się kolejnym krokiem milowym w leczeniu chorób nowotworowych, przede wszystkim chorób rozrostowych układu krwiotwórczego, u dzieci. Badania dotyczące komórek CAR-T zostały zainicjowane w latach 90. XX wieku, a w 2017 r. FDA na podstawie wyników badania klinicznego ELIANA zatwierdziła terapię CAR-T w leczeniu dzieci z ostrą białaczką limfoblastyczną z prekursora limfocyta B (pB-ALL), która jest najczęstszą chorobą nowotworową i najczęstszą białaczką w populacji pediatrycznej. Wprawdzie dzięki obecnie stosowanej terapii konwencjonalnej aż ok. 80-90% dzieci z pB-ALL uzyskuje trwałą remisję, jednak u pozostałych ok. 10-20% spostrzega się chemiooporną lub nawrotową postać pB-ALL, w tym nawrót po allogenicznej transplantacji komórek krwiotwórczych (allo-HSCT). U wymienionych dzieci zastosowanie terapii CAR-T – w odróżnieniu od innych opcji terapeutycznych – daje realną szansę na uzyskanie kolejnej trwałej remisji białaczki. Terapia CAR-T znajduje również zastosowanie w leczeniu Filadelfia-dodatniej ALL z nietolerancją lub niepowodzeniem leczenia inhibitorami kinazy tyrozynowej oraz u dzieci ze wskazaniami do allo-HSCT jednak bez kwalifikacji do transplantacji z powodu choroby współistniejącej, wysokiego ryzyka powikłań kondycjonowania lub braku dawcy komórek krwiotwórczych. Terapia CAR-T ukierunkowana na antygen CD19 stosowana jest z powodzeniem także w leczeniu nawrotowych i opornych chłoniaków B-komórkowych. Sukces terapii CAR-T w leczeniu rozrostów B-komórkowych przyczynił się podjęcia badań dotyczących zastosowania tej terapii w leczeniu niepowodzeń T-komórkowej ALL oraz ostrej białaczki szpikowej, a także niektórych guzów ośrodkowego układu nerwowego i zwojaka zarodkowego współczulnego. Ponadto obecnie realizowane są badania kliniczne oceniające bezpieczeństwo i skuteczność zastosowania allogenicznych CAR-T w leczeniu pB-ALL u dzieci.
Association between 82Rb positron emission tomography-derived regional myocardial blood flow, severity of angiographic coronary artery stenosis, and mortality in patients with chest pain
Authors: Gallegos Cesia , Paredes Camila Trejo , Hu Jiun-Ruey , Posada Edith L. , Saito Yuichi , Lansky Alexandra , Shah Samit , Liu Yi-Hwa , Smolderen Kim G. , Mena-Hurtado Carlos , Sinusas Albert J. , Miller Edward J.
Published: September 2024

Impairment in global myocardial flow reserve (MFR) on rubidium-82 (82Rb) positron emission tomography (PET) stress testing predicts cardiovascular events; however, the relationship between regional coronary artery territory myocardial blood flow (MBF) and invasive coronary angiography is unknown. In this study, patients with acute chest pain who were referred for coronary angiography after abnormal PET stress testing were evaluated. Both global and regional coronary territory stress and rest MBF were derived using 82Rb PET. Coronary artery stenosis severity was assessed using quantitative coronary angiography (QCA) performed within 3 months of PET. A total of 189 patients were followed for a median of 4.1 years. The results showed a weak correlation between regional MFR impairment (<1.7) and stenosis severity in the left descending artery (r = −0.20, P = 0.005), left circumflex artery (r = −0.15, P = 0.042), and right coronary artery (r = −0.26, P < 0.001). In addition, a weak correlation was observed between global MFR and stenosis in any vessel, in both binary and continuous analyses. However, impairment in MFR within any territory was associated with increased all-cause mortality in both unadjusted and adjusted analyses. In conclusion, this is the first large-scale study to examine the relationship between regional coronary territory MBF, coronary artery stenosis severity as assessed using QCA, and mortality. Although coronary territory MFR demonstrated a weak correlation with coronary stenosis severity, impairment in per-territory MFR was significantly associated with increased all-cause mortality, suggesting that mechanisms such as diffuse atherosclerosis and/or microvascular disease may be contributing factors.