bluuebunny/crossref_metadata_2025 huggingface dataset:
Determining the Temporal Factors of Survival Associated with Brain and Nervous System Cancer Patients: A Hybrid Machine Learning Methodology
Authors: Nath Gopal , Coursey Austin , Ekong Joseph , Rastegari Elham , Sengupta Saptarshi , Dag Asli Z. , Delen Dursun , Delen Dursun
Published: August 2022

Purpose.
Although different cancer types have been investigated from the perspective of biomedical sciences, machine learning-based studies have been scant, particularly in addressing the temporal impact of brain and central nervous system (BCNS) cancer survival. The present study aims to fill this gap by proposing a machine learning methodology to investigate the temporal effects of the attributes and the levels at which they are associated with BCNS cancer survival.
Methods.
Following the best practices in health analytics, the proposed methodology utilizes a variety of feature selection, data balancing, and sensitivity analysis methods to optimize the knowledge discovery process and the resultant outcomes.
Results.
The findings can potentially assist medical professionals in identifying and targeting specific subsets of features and levels of attributes associated with sharply decreasing (or increasing) survival rates; thereby implementing better treatment options to improve the survival chances of BCNS cancer patients.
Conclusion.
Although the proposed hybrid methodology is validated on a large and feature-rich BCNS cancer data set, it can be utilized to study survival prognostics of other cancer or chronic disease types.
Metabolomic and lipidomic landscape of porcine kidney associated with kidney perfusion in heart beating donors and donors after cardiac death
Authors: Stryjak Iga , Warmuzińska Natalia , Łuczykowski Kamil , Urbanellis Peter , Selzner Markus , Bojko Barbara
Published: August 2022

With the ever-increasing shortage of kidney donors, transplant centers are faced with the challenge of finding ways to maximize their use of all available organ resources and extend the donor pool, including the use of expanded criteria donors. To address the need for a new analytical solution for graft quality assessments, we present a novel biochemical analysis method based on solid-phase microextraction (SPME) – a chemical biopsy. In this study, renal autotransplantation was performed in porcine models to simulate two types of donor scenarios: heart beating donors (HBD) and donors after cardiac death (DCD). All renal grafts were perfused using continuous normothermic ex vivo kidney perfusion. The small diameter of SPME probes enables minimally invasive and repeated sampling of the same tissue, thus allowing changes occurring in the organ to be tracked throughout the entire transplantation procedure. Samples were subjected to metabolomic and lipidomic profiling using high-performance liquid chromatography coupled with a mass spectrometer. As a result, we observed differences in the profiles of HBD and DCD kidneys. The most pronounced alterations were reflected in the levels of essential amino acids, purine nucleosides, lysophosphocholines, phosphoethanolamines, and triacylglycerols. Our findings demonstrate the potential of chemical biopsy in donor graft quality assessment and monitoring kidney function during perfusion.
p20BAP31 induces cell apoptosis via both ROS/JNK mitochondrial pathway and AIF caspase-independent pathway
Authors: Jiang Xiaohan , Li Guoxun , Zhu Benzhi , Zang Jingnan , Jiang Rui , Wang Bing
Published: August 2022

Background
B-cell receptor associated protein 31 (BAP31) is a polytopic integral endoplasmic reticulum (ER) membrane protein. During cell apoptosis, the c-terminal of BAP31 was cleaved by caspase-8, generates the residual 20kDa proteolytic fragment (p20BAP31), which not only induces cell apoptosis, but also initiates a paraptosis-like cell death pathway when expressed ectopically. This property of inducing cell apoptosis through multiple pathways makes p20BAP31 potentially valuable in the research of anti-tumor therapy. However, the underlying mechanisms of p20Bap31 on cell apoptosis remain to be elucidated in detail. Therefore, it is very important to evaluate the efficiency of p20BAP31-induced apoptosis in different types of cells, and to investigate the molecular mechanisms of p20BAP31 on cell apoptosis.
Methods
Cell viability and colony formation assays were performed to examine the antigrowth effects of p20Bap31 in HCT116 cells. Wound-healing assay was conducted to assess cell migration capacity. Cell cycle and apoptosis were investigated by flow cytometry and verified by immunoblotting. AIF translocate from the mitochondria to the nuclei was verified by immunoblotting and immunofluorescence assay.
Results
We found that overexpression of p20BAP31 can indeed induce apoptosis, and has a much greater sensitivity in human colorectal carcinoma cell line (HCT116). Furthermore, the overexpression of p20BAP31 could inhibit cell proliferation by causing S phase arrest, the migratory ability was also obviously inhibited. The further study revealed that p20BAP31 reduced mitochondrial membrane potential (MMP) with a significant increase in reactive oxygen species (ROS) levels, accompanying with the activation of the MAPK signaling pathway. The mechanism investigation indicated that p20BAP31 could induce mitochondrial-dependent apoptosis by activating ROS/JNK signaling pathway. Importantly, we found that p20BAP31 may also induce caspase-independent apoptosis by promoting the nuclear translocation of apoptosis inducing factor (AIF).
Conclusions
p20BAP31 induced cell apoptosis via both ROS/JNK mitochondrial pathway and AIF caspase-independent pathway. These effects are especially pronounced in HCT116 cell line, implied that p20BAP31 may exert as a potent drug target for the prevention and treatment of colorectal cancer (CRC).
Rate and Frequency of Poultry Manure on Growth and Yield of Fluted Pumpkin (Telfairia Occidentalis Hook. F.)
Authors: Akintoye Oluwatomilayo Hannah , Odedina Joy Nwakaego , Makinde Eyitayo Adekunle , Adigbo Sunday Ojo
Published: August 2022

Fluted pumpkin (Telfairia occidentalis Hook. F.) cultivation is predominantly done by smallholder farmers but scarcity and high cost of inorganic fertilizers have limited its usage and shifted to viable alternative. Field experiments were carried out in the Crop Research Farm, Federal University of Agriculture, Abeokuta, Ogun State Nigeria from November 2018 to August 2019 and from August 2019 to August 2020 cropping seasons to determine the effects of poultry manure (PM) rate and frequency of application on agronomic performance of fresh shoot, pod and seed yields of Telfairia occidentalis. The study involved three rates: 5, 10 and 15 t ha− 1 of PM as main plot and four frequency of PM application: once, twice, thrice and at every harvest and a control plot laid out in split-plot arrangement and fitted into a Randomized Complete Block Design, replicated three times. In 2018, Poultry manure at 15 t ha− 1 increased fresh shoot weight at 6 to 14 weeks after planting (WAP) relative to 5 t ha− 1 and 10 t ha− 1 PM rate. In 2019, interaction of PM at 5 t ha− 1 applied thrice significantly increased fresh shoot weight by 85.4% at 14 WAP relative to 15 t ha− 1 PM applied once. Interaction of PM at 10 and 15 t ha− 1 applied thrice and at every harvest respectively gave similar results on cumulative fresh shoot weight while the plants in control plots produced significantly lower fresh shoot weight in 2018. There were no significant differences observed in weight of pod and seed weight/plant with PM rate, frequency and interaction in 2018 and 2019 cropping. The study concluded that 10 t ha− 1 PM rate applied thrice enhanced cumulative fresh shoot yield in fluted pumpkin in the study area.
Transcriptome and Population Structure of Glassy-winged Sharpshooters (Homalodisca vitripennis) with Varying Insecticide Resistance in Southern California
Authors: Ettinger Cassandra , Byrne Frank , Pacheco Inaiara de Souza , Brown Dylan , Walling Linda , Atkinson Peter , Redak Richard , Stajich Jason
Published: August 2022

Background
Homalodisca vitripennis Germar, the glassy-winged sharpshooter, is an invasive insect in California and a critical threat to agriculture through its transmission of the plant pathogen, Xylella fastidiosa. Quarantine, broad-spectrum insecticides, and biological control have been used for population management of H. vitripennis since its invasion and subsequent proliferation throughout California. Recently wide-spread neonicotinoid resistance has been detected in populations of H. vitripennis in the southern portions of California’s Central Valley. In order to better understand potential mechanisms of H. vitripennis neonicotinoid resistance, we performed RNA sequencing on wild-caught insecticide-resistant and relatively susceptible sharpshooters to profile their transcriptome and population structure.
Results
We identified 81 differentially expressed genes with higher expression in resistant individuals. The significant largest differentially expressed candidate gene linked to resistance status was a cytochrome P450 gene with similarity to CYP6A9. Furthermore, we observed an over-enrichment of GO terms representing functions supportive of roles in resistance mechanisms (cytochrome P450s, M13 peptidases, and cuticle structural proteins). Finally, we saw no evidence of broad-scale population structure, perhaps due to H. vitripennis' relatively recent introduction to California or due to the relatively small geographic scale investigated here.
Conclusions
In this work, we characterized the transcriptome of insecticide-resistant and susceptible H. vitripennis and identified candidate genes that may be involved in resistance mechanisms for this species. Future work should seek to build on the transcriptome profiling performed here to confirm the role of the identified genes, particularly the cytochrome P450, in resistance in H. vitripennis. We hope this work helps aid future population management strategies for this and other species with growing insecticide resistance.
PERANCANGAN UI/UX SEMARANG VIRTUAL TOURISM DENGAN FIGMA
Authors: Al-Faruq Muhammad Naufal Muhadzib , Nur’aini Siti , Aufan Muhammad Haikal
Published: August 2022

Kota Semarang merupakan salah satu kota besar yang ada di Indonesia dan memiliki banyak cagar budaya. Pemerintah Kota Semarang telah berupaya melakukan pemugaran beberapa cagar budaya agar lebih layak menjadi tujuan wisata. Hal tersebut dilakukan dalam upaya untuk meningkatkan ekonomi lokal.  Usaha pemerintah Kota Semarang tidak berhenti sampai pada pemugaran cagar budaya, tetapi juga dengan melakukan berbagai promosi agar Kota Semarang dikenal lebih luas sebagai kota tujuan wisata. Untuk mendukung upaya pemerintah tersebut, penulis mempunyai gagasan berupa perancangan prototype Aplikasi Semarang Virtual Tourism. Pengumpulan data dilakukan dengan observasi dan wawancara. Sedangkan perancangan prototype menggunakan Figma. Figma dipilih sebagai media untuk merancang prototype ini karena Figma berbasis cloud sehingga memudahkan kerja sama tim. Aplikasi Semarang Virtual Tourism ini dirancang dengan desain yang sederhana dan menarik agar memudahkan pengguna. Aplikasi Semarang Virtual Tourism  ini dapat memberikan informasi tentang cagar budaya dan kuliner yang ada di Kota Semarang. Kata Kunci: Semarang City, prototype, figma
Integrating into the System: Local Self-Government in the Context of the New Federal Reform
Authors: Zazulina Mariya
Published: August 2022

The author analyzed the upcoming reform of local self-government initiated by amendments to the Constitution of the Russian Federation (2020) and the Draft Federal Law No. 40361-8 "On general principles of the organization of local self-government in a unified system of public authority", submitted to the State Duma of the Russian Federation in December 2021.

The research objective was to identify and analyze the features of the reorganization of local self-government during its integration into a unified system of public authority and the implementation of innovations proposed by the new law on local self-government. The analysis included the legislative foundation and various data on local self-government provided by the Ministries of Finance and Justice. The author concentrated on the unified system of public power, the local self-government as an element of this system, the proposed innovations, and their consequences for the institutional organization of local self-government. At the new stage, such problems of local self-government as poor manageability and low efficiency are likely to be solved by including them in the unified system of public authority. Governmentalization increases as self-government loses institutional autonomy and turns into a lower level of the management vertical. Further unification takes place within the system of local self-government and within the elements of the unified system of public authority, i.e., between municipal and regional levels of government. A simplified system of local self-government follows a single-level model, with a significant reduction in the diversity and number of municipalities, deputies, competences, etc. The chosen strategy reforms should be considered as a conscious choice by legislators of the further domestic self-government development. The strategy abandons the principle of unconditional transit to democratic institutions and turns to a model that includes the current socio-economic, political, and cultural realities of Russia.
Volunteers on Volunteering
Authors: Suhar'kova Marina
Published: August 2022

Sporting mega-events improve local economy, affect political processes, and develop such non-commercial sector as volunteering. The article examines the attitude of volunteers to the legacy of such sporting mega-events as Olympic or Paralympic Games. An online survey of volunteers (n=332) who participated in the Olympic and Paralympic Games in 2014 defined various problems that hinder the development of volunteering in Russia. Most respondents were satisfied with their volunteering experience and expressed eagerness to volunteer specifically in this area. They remarked on the increase in the number of volunteer centers and volunteers in Russia as the most significant consequences of the Olympic Games in the field of volunteering. The research results contribute to the Olympic studies and cast light on the public attitude to Olympic volunteering.
Scenario Model for Assessing the Corporate Financial and Economic Performance
Authors: Kozlova Dar'ya , Bykov Vadim , Yakshilov Igor'
Published: August 2022

The paper introduces a new economic scenario-based Excel model of the strategic development of a commercial organization. The method solves such problems as short-term focus, poor strategic goals, and the complexity of a comprehensive economic analysis of corporate financial and economic activities. The research featured the methodological tools for evaluating the financial and economic performance of a commercial organization, as well as ways to optimize it. The authors used various methods of experimental and theoretical analysis, as well as the current legislative and subordinate regulatory legal acts, academic editions, and research publications on complex economic analysis, analysis of financial and economic corporate performance, reserve analysis, step out analysis, etc. The new model is based on a general performance indicator that includes twenty performance indicators. The model was experimentally tested at Stroyrezultat LLC and proved to be effective and user-friendly.
Virulence markers, adhesion and biofilm formation of Escherichia coli strains isolated from drinking water supplies of north Paraná State, Brazil
Authors: Schüroff Paulo Alfonso , Andrade Fernanda Batista , Pelayo Jacinta Sanchez
Published: August 2022

Waterborne diseases are a major public health problem responsible for a high number of deaths worldwide, of which Escherichia coli is a major agent of contamination. This study investigates the occurrence of different diarrheagenic E. coli (DEC) pathotypes and its relationship with adherence patterns and biofilm formation. Between 2012 and 2014, a total of 1,780 drinking water samples were collected from different rural communities and urban water systems of north Paraná State. A total of 14% were positive for E. coli and 250 non-duplicate E. coli isolates were obtained. Between the E. coli isolates, 28 (11.2%) harbored DEC-associated genes, 10.7% being classified as Shiga toxin-producing E. coli (STEC), 64.3% enteroaggregative E. coli (EAEC) and 25% atypical enteropathogenic E. coli (aEPEC). The aggregative adherence (AA) was the predominant adherence pattern (84%), significantly associated with biofilm formation (p < 0.0001). On the other hand, the AA pattern and biofilm formation were not significantly associated to DEC pathotypes (p > 0.05). Therefore, we proposed that the AA pattern and biofilm formation in E. coli isolated from drinking water supplies could be associated with adherence and colonization of abiotic surfaces, such as pipes, leading to persistence and resistance to treatment or disinfection.
Policy effectiveness of water conflict management: A textual analysis of the Nansi Lake
Authors: Yang Dan , Ji Hanyu , Yang Danyan , Song Jiajing , Li Yan , Peng Jianhui , Xue Liuyu , Chen Zhisong
Published: August 2022

Global warming and social and economic development have led to conflicts over water resources that have gradually become one of the most disruptive factors in the global political landscape. Resolving international water conflicts is of great significance for maintaining the peaceful development of countries (regions). This paper considers the Nansi Lake located on the provincial border of Jiangsu and Shandong in eastern China as an example. Based on the textual analysis, this paper analyzes the specific data of the historical conflict resolution of the Nansi Lake to study the effectiveness of the management policies of water conflict in the Nansi Lake, namely administrative law enforcement, administrative consultation, civil consultation, policy regulation, and engineering measures. Furthermore, this paper also makes the following optimization recommendations for the policy of water conflict management by considering the successful circumstances for the policies to be applied: strengthen the government's deterrence in administrative law enforcement to promote the development of policies; promote administrative consultation and equal dialogue and exchanges among parties; understand the positions of the different parties in the civil consultation and ensure their independence of cooperation and analysis; improve the ability of scientific decision-making and effective operation for water administration department; strengthen construction management, especially effective supervision.
The unintended effects of inter-basin water transfer policies on corporate research and development activities
Authors: Sheng Jichuan , Xin Jing , Tang Weizong
Published: August 2022

Inter-basin water transfer (IBWT) policies alter the spatial distribution of water endowments and trigger changes in environmental regulation policies, which may unintentionally impact the research and development (R&D) activities in IBWT water-receiving areas. However, the existing studies failed to examine the relationship between IBWT policies and corporate R&D activities, and lacked the exploration of the micro-mechanism of IBWT's unintended impact on corporate R&D activities. Through the water delivery of China's South-North Water Transfer Project as a quasi-natural experiment, this study adopts a difference-in-differences approach to scrutinise the unintended impact of IBWT policies on corporate R&D activities. The findings show that IBWT policies can make the water a ‘resource blessing’ by directly improving the water endowment in water-receiving areas, thereby promoting corporate R&D activities. In addition, IBWT policies can also indirectly encourage local governments in water-receiving areas to strengthen the intensity of environmental regulations, ultimately promoting companies to improve R&D activities. Finally, the impacts of IBWT policies on corporate R&D activities in water-receiving areas are heterogeneous. Overall, this study contributes to understanding the complicated relationship between IBWT policies and corporate R&D activities, and provides insights into how IBWT policies affect corporate R&D activities.
El Apocalipsis del Leviatán: Escatología en el proyecto político de Thomas Hobbes
Authors: Abdala Simón
Published: August 2022

The main objective of this presentation is to determine the role played by eschatology within the political thought of Thomas Hobbes. In order to determine this role, it is fundamental to give an account of the bibliographic framework used for this presentation. Moreover, there will be an analysis on the relationship of the concepts of "death of State," "history," and "contract," and Hobbes’s main consequences in the post-apocalyptic political landscape. Finally, there will be an interpretation of Hobbes's use of eschatology responding the following question: Is eschatology just a rhetorical device, or is it essential for the entire structure of its political system?
Hygienic and sanitary characteristics of dry salted fish marketed in Porto Velho city, Rondônia – Brazil
Authors: Pontuschka Rute Bianchini , Araujo Analice Timoteo de , Silva Mayline Álex Contes da , Dantas Filho Jerônimo Vieira , Marmentini Regiane Pandolfo , Schons Sandro de Vargas , Cavali Jucilene
Published: August 2022

Handcrafted salted fish is marketed weekly in retail markets and public fairs in the Porto Velho city, Rondônia sate, Brazil. Knowing the microbiological quality of these products is essential for public health, given that such products are not subject to any quality control. The aimed of the study was to evaluate the hygienic-sanitary characteristics and the moisture content of pirarucu and salted and dried shrimp marketed in the Porto Velho city. Twenty samples were collected, 10 pirarucu and 10 shrimp, in February and June 2019. For microbiological analysis, surface plating was performed using acidified potato agar, for molds and yeasts, and PCA agar for halophilic bacterias. Moisture was determined by gravimetry, using an oven at 105° C. Results for molds and yeasts on pirarucu ranged <10 log CFU/g (absent) to 3 log CFU/g. For shrimp, values ranged <10 log CFU/g to 3.57 log CFU/g. For halophilic bacterias, contents ranged <10 log CFU/g to 6.30 log CFU/g in pirarucu samples and <10 log CFU/g to 6.97 log CFU/g in shrimp samples. The variation in moisture content ranged 36.99 to 54.31% for pirarucu, and 40.6 to 56.82% for shrimp. The results obtained may be related to poor hygienic conditions in processing, the lack of hygiene of utensils and places for handling, or even the quality of the raw material used.
Managing power infrastructure using LiDAR
Authors:   College of Business and Economics, California State University, Long Beach, USA, et al. Sultan
Published: August 2022

This manuscript empirically focuses on machine learning to identify objects from point-cloud data. The literature suggests deep learning can be used as a tool to classify objects of interest. Researchers in this study used light detection and ranging (LiDAR) point-cloud data to identify power poles and towers. This study sought to demonstrate the use of a deep-learning model developed by a group based in Australia and ESRI to determine whether deep learning is a viable solution for identifying power assets in three California areas. This study instantiated an existing trained model to determine whether deep learning is an effective solution for extracting the desired objects from point-cloud data. The deep-learning model successfully identified power poles in both rural and urban areas. However, the model performance was better in urban areas than in rural areas. This study supports the literature that deep learning can successfully classify point clouds. To improve the model performance and to ensure optimal results when training the model, the authors emphasize the importance of accurately labeled data to represent the objects of interest. To produce the desired results, one should develop one’s own training and validation data.
دور إدارة التعليم الجامعي في تعزيز قيم المواطنة لدى الطلاب
Authors: Hama Salah Atta Adam
Published: August 2022

الهدف من البحث هو التعرف على مستوى قيم المواطنة في إدارة التعليم الجامعي بجامعة السليمانية التقنية والتعرف على دور ادارة الجامعة فيه بتنمية وتعزيز قيم المواطنة لدى طلابه، ولتحقيق الهدف قام الباحث بإختار ثلاثة مجالات، أولها: إدارة التعليم الجامعي، وثانيها: الهيئة التدريسية في الجامعة، وثالثها: المناهج التعليمية في الجامعة، واستخدم الباحث ( منهج الوصفي التحليلي) حيث قام بتصميم استبانة خاصة لهذا الغرض، وشملت عبارات الاستبانة عدة محاوروبفقرات بلغت (45 ) فقرة. مجتمع البحث عبارة عن اساتذة وطلبة مرحلتي الثالثة والرابعة لاربع كليات جامعة التقنية السليمانية، البالغ عددهم (1457) فرداً، وتم اختيارعينة عشوائية بسيطة، مكونة من( 100)اساتذة و(400) طالبا وطالبة، وبعد استعادت(429) من الاستبانات تم استبعاد(32) منها، لعدم صلاحيتها لاغراض التحليل لظروف خارجة عن إرادة الباحث، فتمثلت العينة بـ ( 397 ) استبانة، وتم إخضاع إجابات المبحوثين للتحليل الاحصائي بإستعمال الحقيبة الاحصائية للعلوم الاجتماعية(Spss ) وبتحليل البيانات اسفر البحث الى عدة استنتاجات من أبرزها هي:

رغم الدور الكبير الذي تلعبه الجامعة في تعزيز قيم المواطنة، لكن مازال دورها قاصرا على التحقيق الفعلي والواقعي لهذا الهدف.
تقارب وجهات النظر بين الاساتذة والطلاب حول نوع من الدور الايجابي للهيئة التدريسية في تعزيز قيم المواطنة لدى الطلبة.
غالبية المبحوثين يرون ان المناهج التعليمية خالية من موضوعات وقضايا تعزز قيم المواطنة لدى الطلبة.

وبناءا على نتائج البحث يوصي الباحث ب:

حث المؤسسات التعليم الجامعي على الاهتمام بتعزيز مكانة الوطن في نفوس الطلبة من خلال تنمية الوعي وزرع الاعتزاز بالوطن لدى الطلبة.
الاعتماد على المعايير الموضوعية والحيادية والشفافية عند اختيار المسؤولين القائمين على ادارة ومؤسسات الجامعية.
توفير المناخ الجامعي المناسب والعمل على تحقيق العدل والمساواة في معاملة الطلاب، وبناء علاقات انسانية فاعلة معهم، وعدم التفرقة بينهم لاسباب سياسية واجتماعية .
تطوير المناهج التعليمية بالنشاطات والفعاليات بما يحقق ويُعزز قيم المواطنة لدى الطالب.
App-Based Evaluation of Older People’s Fall Risk Using the mHealth App Lindera Mobility Analysis: Exploratory Study
Authors: Strutz Nicole , Brodowski Hanna , Kiselev Joern , Heimann-Steinert Anika , Müller-Werdan Ursula
Published: August 2022

Background

Falls and the risk of falling in older people pose a high risk for losing independence. As the risk of falling progresses over time, it is often not adequately diagnosed due to the long intervals between contacts with health care professionals. This leads to the risk of falling being not properly detected until the first fall. App-based software able to screen fall risks of older adults and to monitor the progress and presence of fall risk factors could detect a developing fall risk at an early stage prior to the first fall. As smartphones become more common in the elderly population, this approach is easily available and feasible.

Objective

The aim of the study is to evaluate the app Lindera Mobility Analysis (LIN). The reference standards determined the risk of falling and validated functional assessments of mobility.

Methods

The LIN app was utilized in home- and community-dwelling older adults aged 65 years or more. The Berg Balance Scale (BBS), the Tinetti Test (TIN), and the Timed Up & Go Test (TUG) were used as reference standards. In addition to descriptive statistics, data correlation and the comparison of the mean difference of analog measures (reference standards) and digital measures were tested. Spearman rank correlation analysis was performed and Bland-Altman (B-A) plots drawn.

Results

Data of 42 participants could be obtained (n=25, 59.5%, women). There was a significant correlation between the LIN app and the BBS (r=–0.587, P<.001), TUG (r=0.474, P=.002), and TIN (r=–0.464, P=.002). B-A plots showed only few data points outside the predefined limits of agreement (LOA) when combining functional tests and results of LIN.

Conclusions

The digital app LIN has the potential to detect the risk of falling in older people. Further steps in establishing the validity of the LIN app should include its clinical applicability.

Trial Registration

German Clinical Trials Register DRKS00025352; https://tinyurl.com/65awrd6a
Three Times Weekly Dosing of Daprodustat versus Conventional Epoetin for Treatment of Anemia in Hemodialysis Patients
Authors: Coyne Daniel W. , Singh Ajay K. , Lopes Renato D. , Bailey Christine K. , DiMino Tara L. , Huang Chun , Connaire Jeffrey , Rastogi Anjay , Kim Sung-Gyun , Orias Marcelo , Shah Sapna , Patel Vickas , Cobitz Alexander R. , Wanner Christoph
Published: August 2022

Background and objectives

Daprodustat is a hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI) being investigated for the treatment of anemia of CKD. In this noninferiority trial, we compared daprodustat administered three times weekly with epoetin alfa (epoetin) in patients on prevalent hemodialysis switching from a prior erythropoiesis-stimulating agent (ESA).

Design, setting, participants, & measurements

Patients on hemodialysis with a baseline hemoglobin of 8–11.5 g/dl receiving an ESA were randomized 2:1 to daprodustat three times weekly (n=270) or conventional epoetin (n=137) for 52 weeks. Dosing algorithms aimed to maintain hemoglobin between 10 and 11 g/dl. The primary end point was mean change in hemoglobin from baseline to the average during the evaluation period (weeks 28–52). The principal secondary end point was average monthly intravenous iron dose. Other secondary end points included BP and hemoglobin variability.

Results

Daprodustat three times weekly was noninferior to epoetin for mean change in hemoglobin (model-adjusted mean treatment difference [daprodustat-epoetin], −0.05; 95% confidence interval, −0.21 to 0.10). During the evaluation period, mean (SD) hemoglobin values were 10.45 (0.55) and 10.51 (0.85) g/dl for daprodustat and epoetin groups, respectively. Responders (defined as mean hemoglobin during the evaluation period in the analysis range of 10 to 11.5 g/dl) were 80% in the daprodustat group versus 64% in the epoetin group. Proportionately fewer participants in the daprodustat group versus the epoetin group had hemoglobin values either below 10 g/dl or above 11.5 g/dl during the evaluation period. Mean monthly intravenous iron use was not significantly lower with daprodustat versus epoetin. The effect on BP was similar between groups. The percentage of treatment-emergent adverse events was similar between daprodustat (75%) and epoetin (79%).

Conclusions

Daprodustat was noninferior to epoetin in hemoglobin response and was generally well tolerated.

Clinical Trial registry name and registration number:

Anemia Studies in Chronic Kidney Disease: Erythropoiesis via a Novel Prolyl Hydroxylase Inhibitor Daprodustat–Three Times Weekly Dosing in Dialysis (ASCEND-TD), NCT03400033
Criterios elementales para la finalización del tratamiento de ortodoncia
Authors: Puebla Ramos Lorenzo
Published: August 2022

La etapa de fi nalización de un tratamiento de ortodoncia es quizá la etapa más compleja y difícil de llevar a cabo, ya que signifi ca tomar la decisión de terminarlo adecuadamente en todos los ámbitos que se requieren o simplemente terminarlo, además, en más de una ocasión estamos bajo cierto estrés por diversas circunstancias como lo es la desesperación por parte del paciente, que ya se quiere ver sin aparatología.
Corrección ortodóntica quirúrgica de paciente clase III laterognata. Presentación de caso clínico
Authors: Leyva Castrejón Nivis Avyely , Gómez Arenas Antonio , Loranca Fragoso Gabriel
Published: August 2022

Se presenta caso clínico de paciente femenino de 26 años de edad que acude al Departamento de Ortodoncia de la Facultad de Odontología de la UNAM, sin datos patológicos aparentes. En exploración física se observa asimetría facial marcada con desviación mandibular izquierda, perfil recto, dolicofacial, retroquelia superior y nariz gibosa. Intraoralmente presenta aparatología fija, ausencias dentales 25 y 47, líneas medias dentales no coincidentes, arcadas ovaladas, relación clase III molar y canina bilateral con mordida cruzada anterior. Radiográficamente presenta 27 dientes erupcionados, ausencia de OD (órgano dentario) 25 y 47 y asimetría mandibular. Como diagnóstico cefalométrico obtuvimos clase III esquelética biprotrusiva, exceso vertical del maxilar, patrón de crecimiento vertical, laterognasia izquierda y retroinclinación de incisivos inferiores. El tratamiento consistió en tres fases: 1) Ortodoncia prequirúrgica realizada con aparatología Roth con slot 0.022” autoligado, con una secuencia de arcos personalizada de acuerdo con las necesidades del paciente. 2) Fase quirúrgica realizada intrahospitalariamente, la cual consistió en sagitales de ramas bilaterales para la corrección de laterognasia, retroposición de la mandíbula, e impactación del maxilar para la corrección de exceso vertical. 3) Fase ortodoncia posquirúrgica, en la cual se detalló el caso corrigiendo patrones musculares y asentamiento oclusal.
Smart Home Automation System Using Arduino
Authors: Sri C. Haritha , Ammu K. , Banu Dr. S. Saira , Chinnasamy Dr. G.
Published: August 2022

Abstract: Smart home automation system enables us to control over home appliances using smart phones. This project is created on an Arduino board with android software and a Bluetooth module (HC-05). In the context of a smart home environment that emphasises interoperability, reliability, integration of smart homes and privacy in context. Bluetooth is used for physically disabled people allowing them to remotely control home appliances like lighting, heating systems, and security measures using a smartphone
Temporal Variations and Futuristic Projections of Temperature and Precipitation: A study of Vijayawada city
Authors: Madapala Jeevan , Jampana Sri Gowtham Raju , Gedela Sumathi
Published: August 2022

Abstract: Examining the temporal dynamics of meteorological variables in the context of changing climate, particularly in Vijayawada, where agriculture is predominant. Therefore, the study uses trend analysis of rainfall and temperature change in Vijayawada using precipitation data obtained from Precipitation and temperature data. Data have been analysed using the coefficient of variation and standard deviation. Furthermore, the Mann-Kendall test was used to detect the time series trend. The result revealed variability of rainfall and temperature. The month-wise analysis of the temperature and precipitation trends established different unique patterns. This is due to the fact that the sensitivity of the world to climate change varies temporally and spatially. The scope of the study lies in developing the analysis to study different extreme events such as cloudbursts, heat waves, cold waves, etc. Furthermore, the spatial variations of the study can be used to establish the climate sensitivity with temporal factors.
Yield Prediction and Reaping Recommendation System Using Machine Learning
Authors: Nirosha E , Sreerambabu Dr. J. , Riyaz M Mohammed
Published: August 2022

Abstract: Agriculture is the field that assumes a significant part in working on our nation'seconomy. Horticulture is the one that brought forth human advancement. India is an agrarian nation and its economy is generally founded on crop efficiency. Henceforth we can say that farming can be the spine of all business in our country. This undertaking will assist the ranchers with knowing the yield of their harvestbefore developing onto the horticultural field and subsequently assist them with settlingon the fitting choices. It endeavors to address the issue by building a model of an intuitive expectation framework. Execution of such a framework with a simple to- utilize online realistic UI and the AI calculation will be completed. The consequences of the expectation will be made accessible to the rancher. The choice of yields will rely on the various boundaries, for example, market cost, creation rate, and the different government strategies. Furthermore, the harvests can be cultivated in like manner utilizing state of the soil, climate projections, and the examination of water expected to develop the specific yields lossless. The irregular woodland calculation is utilized. By investigating this large number of issues and issueslike climate, temperature, mugginess, precipitation, dampness, there could be noappropriate arrangement and innovations to defeat what is going on looked by us. Stepby step the number of inhabitants in India is developing and the usefulness of the yieldshould be expanded to take care of the populace. The application expects to foresee crop yield so it could assist ranchers with picking the best seeds for plantation. Randombackwoods is the most well known and strong directed AI calculation equipped for performing both order and relapse assignments, that work by building a huge number of choice trees during preparing time and producing a result of the class that is the method of the classes (arrangement) or mean forecast (relapse) of the singular trees. The idea of this paper is to carry out the harvest yielding technique with the goalthat this strategy helps in tackling numerous agribusiness and ranchers issues. This works on our Indian economy by expanding the yield pace of harvest creation.
Virtual Fence Geospatial Intelligence to Protect Enterprise Cloud Server Data
Authors: Pandiaraj S. , Sreerambabu Dr. J. , Rajkumar D.
Published: August 2022

Abstract: Data sharing and access area unit capabilities businesses and organizations need the foremost currently. Remote operating and mobile access to resources and collaboration platforms created it easier to access knowledge and resources from anyplace, anytime. Employees need to access documents and email from completely different devices, and from varied locations at a time. Access from untrusted networks is usually a threat to businesses. This may lead to knowledge loss and overexposure of essential knowledge. To mitigate the deficiencies of logical security mechanisms, and coinciding with the trend of cyber-physical systems, security mechanisms are planned that integrate with the physical surroundings. to make sure that business’s knowledge and resources area unit safe. In this project we tend to propose AN innovative Virtual Fence that uses a location knowledge and geospatial intelligence. Geospatial knowledge analysis enhances understanding, insight, decision-making, and prediction. Location intelligence (LI) is achieved via image and analysis of geospatial knowledge. Then we tend to improve the safety of information access in knowledge Server for an organization or the other specific locations exploitation the location-based cryptosystem. Virtual Fence provides a way to secure sensitive data among a company. It are often set to Off, On, Restricted read or browse solely. Once a geo-fenced boundary is outlined, the opportunities what businesses will do is proscribed by solely their creativeness. The most advantage of fitting such a geo fence is in avoiding knowledge discharge. Once outlined the trusty network locations, nobody will access knowledge from a unique network location/device. The experiment shows that our theme is possible in sensible applications.
Location Based Local Workers Finding Application for Android
Authors: Rathinasethupathi R. , Sreerambabu Dr. J. , Rajkumar D.
Published: August 2022

Abstract: This project aims to select unorganized workers like electricians, mechanic, plumbers, painters, carpenters, etc near us through the android app. It is difficult for customers to find any service anytime anywhere in an emergency so we have developed an android app that helps customers to find the nearest plumbing, electrical, painting, etc jobs easily without any problem through this android app we can provide all services anytime anywhere. It also saves time by finding employees immediately and reducing unemployment.
Arabic-Java Writing System: How Javanese Language Adopts Arabic Script
Authors: Jamalin Fakron , Rahman Asma Abdul
Published: August 2022

Borrowing script happens throughout history of languages. Long before we know Latin script, Javanese has already adopted Arabic script. However, Java language deals with problematic adaptation due to distinctive sound system among those two languages, Arabic and Java. For that matter, this research aims to uncover 1) how Arabic-Java orthography represents Javanese’s consonants and vowel, and 2) how Arabic-Java orthography represents Javanese’s cluster. This research uses qualitative descriptive method. Data contain with the Javanese words which is written in Arabic script. Data are gained from eight different books which are inscribed by Arabic-Java orthography. After data are collected, the orthography method and grapheme-phoneme correspondence are used to analyze them. Grapheme-phoneme correspondence used to know how Arabic-Java orthography represents consonants and vocal phonemes.  Finally, this research found that Arabic-Java orthography has 28 graphemes which are used to represent 23 consonants. Modification letters and digraph are used to represent missing sound in Arabic. Six Javanese vocals are represented with 9 graphemes. In another hand, cluster is written in two ways, first by adding Anaptyxis schwa [ə] in between sonorant-sonorant or obstruent-sonorant and vowel [a] in initial cluster nasal consonant and plosive consonant.
Comparative Analysis of Kaba, Al-’Ashri and Al-Bisri Dictionaries (Lexicography Studies)
Authors: Thoyyibah Anisatu , Eltoukhy Ahmed Mohamed
Published: August 2022

Dictionaries are one of the means of finding vocabulary, especially in foreign languages. Besides, the dictionary also provides other information related to phonology, syntax, semantics, maps, profiles of a person, and others. Although not all dictionaries collect all the information needed by the user. But with a dictionary, it becomes easier to understand a word. The purpose of this study was to compile Kamus Akbar Bahasa Arab (KABA), Al-'Ashri, and Al-Bisri seen from the point of view of lexicography through comparative scalpels by looking at the aspects of the purpose, content, and shape of the three components of the dictionary. Besides, the author also described the similarities and differences among the three dictionaries. This study used a qualitative descriptive method. This type of research is a library research with research objects were Kamus Akbar Arabic (KABA), Al-'Asri, and Al-Bisri. Data collection used of this study was documentation and recording techniques. The data were analyzed using comparative methods. The results of this study showed that the three dictionaries had their advantages and disadvantages. However, observers or Arabic learners can choose one of these three dictionaries according to their purpose
The Quality Improvement of Interaction Indicators in Arabic Language Learning for Higher Education
Authors: Bahruddin Uril , Ramadhan Muhammad Fadli , Halomoan Halomoan , Alzitawi Diaya Uddeen Deab Mahmoud , Hamid M Abdul
Published: August 2022

The success of learning Arabic is largely determined by the quality of interaction in learning. This article aims to describe (1) Increasing speaking skills through Arabic learning interactions, (2) Increasing cooperation through learning interactions, and (3) Increasing solidarity through learning interactions. So far, this aspect has been neglected in existing studies. This research approach is qualitative with the type of case study research. The research data were collected through interviews, observation, and documentation. Data analysis starts from data collection to concluding. The results showed that the improvement of speaking skills was carried out by selecting interesting topics, using familiar vocabulary among students, and giving them motivation. In terms of increasing cooperation, this is done by giving joint assignments, joint corrections, making videos, and playing roles. Meanwhile, in the context of increasing solidarity, the activities carried out are by instilling a sense of brotherhood, group work, and giving responsibility to help each other.
STUDI KEANEKARAGAMAN CAPUNG (ODONATA) SEBAGAI BIOINDIKATOR KUALITAS AIR SUNGAI BRANTAS BATU-MALANG DAN SUMBER BELAJAR BIOLOGI
Authors: Virgiawan Candra
Published: August 2022

ABSTRAKJenis penelitian yang digunakan adalah penelitian deskriptif kuantitatif. Penelitian deskriptif bertujuan untuk mendeskripsikan suatu peristiwa dan kejadian yang terjadi, penelitian kuantitatif bertujuan untuk menjelaskan angka-angka data analisis mengunakan statistik. Penelitian ini dilakukan pada tanggal 25 Juli-16 Agustus 2014 pagi hari dengan metode jelajah (visual day flying). Data dikumpulkan dengan melakukan observasi atau pengamatan langsung terhadap populasi yang diselidiki. Berdasarkan hasil penelitian didapatkan sepuluh jenis spesies capung (Odonata), delapan jenis termasuk dalam sub ordo Anisoptera, Famili Libellulidae yaitu  Diplacodes trivalis, Neurothemis ramburii, Orthetrum glaucum, Orthetrum pruinosum, Orthetrum sabina, Pantela flavescens, Trithemis festiva, Zyxomma obtusum, dan dua jenis termasuk dalam subordo Zygoptera, Famili Chlorocyphidae  yaitu. Libellago lineate dan famili Coenagrionidae yaitu Ischnura sinegalensis. Odonata yang memiliki indeks nilai penting tertinggi yaitu 1.80%  dari famili  Libelludae, Genus Orthetrum, dan jenis Orthetrum Sabina. Nilai keanekaragaman tertinggi terdapat pada lokasi A yaitu 1.62. Nilai indeks kemerataan disemua lokasi mendekati 1 menunjukkan bahwa kondisi habitat pada semua stasiun penelitian adalah heterogen. Berdasarkan hasil analisis korelasi terdapat beberapa faktor abiotik  yang memiliki korelasi yang kuat dengan jumlah  jenis capung yang di temukan,  faktor abiotik tersebut diantaranya adalah intensitas cahaya, DO, dan BOD. Hasil analisis FBI (Famili Biotik Indeks) diperoleh nilai 7,00, hal ini menunjukan bahwa kualitas air sungai Brantas Batu-Malang tergolong dalam kategori buruk dengan tingkat pencemaran terpolusi sangat banyak.Kata Kunci: Odonata,Sungai Brantas, Keanekaragaman jenis
STUDI TRIKOMA DAUN PADA FAMILI SOLANACEAE SEBAGAI SUMBER BELAJAR BIOLOGI
Authors: Dewi Veni Puspita , Hindun Iin , Wahyuni Sri
Published: August 2022

ABSTRAKPenelitian dilakukan dengan melihat jaringan epidermis pada tujuh spesies yang mewakili family solanaceae (Solanum melongena, Solanum tuberosum, Capsicum frustescens, Capsicum annum, Datura metel, Physalis minima dan Lycopersicon pimpinellifolium) yang ditemukan di daerah cangar kota Batu dengan metode jelajah. Kemudian dilakukan penelitian pada epidermis daun di Labolatorium Biologi Universitas Muhammadiyah Malang dengan menggunakan mikroskop SEM. Hasil penelitian menunjukkan bahwa trikoma pada famili solanaceae memiliki bentuk yang bervariasi. Dari 7 spesies ditemukan trikoma rambut sederhana, stellata, berkepala unicel dan hidatoda. Kemudian hasil penelitian ini untuk dikembangkan menjadi sumber belajar biologi SMA kelas XI melalui analisis KD, silabus dan RPP pada materi pembelajaran jaringan tumbuhan dengan penyajian bahan ajar berbentuk buku ilmiah.Kata kunci: Studi bentuk, Trikoma Daun, family Solanaceae, Sumber Belajar