bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Lingkungan Kerja, Kepemimpinan Islami, Dan Budaya Organisasi Islami Terhadap Kinerja Karyawan Dengan Kepuasan Kerja Sebagau Variabel Mediasi (Studi Pada Karyawan PT. Nada Surya Tunggal)
Authors: Anggraeni Salma , Cahyono Edi
Published: November 2024

Karyawan merupakan unsur yang paling penting untuk kemajuan atau kemunduran suatu perusahaan. Untuk memperoleh tujuan perusahaan, tentu memerlukan pekerja yang berdasarkan pada syarat yang dibutuhkan perusahaan. Oleh karena itu, kinerja karyawan yang baik sangat dibutuhkan demi kelangsungan hidup perusahaan tersebut. Penelitian ini bertujuan untuk menganalisis pengaruh langsung dan tidak langsung lingkungan kerja, kepemimpinan islami, dan budaya organisasi islami terhadap kinerja karyawan, dengan kepuasan kerja sebagai variabel mediasi pada karyawan PT. Nada Surya Tunggal dengan sampel 73 responden. Data dari penelitian ini diperoleh dari kuesioner yang telah diedarkan kemudian diuji menggunakan SPSS V25. Dari analisis data yang telah dilakukan menunjukkan bahwa:(1) Lingkungan kerja berpengaruh negatif dan tidak signifikan terhadap kinerja karyawan (2) Kepemimpinan islami berpengaruh positif dan tidak signifikan terhadap kinerja karyawan (3) Budaya organisasi islami berpengaruh positif dan signifikan terhadap kinerja karyawan (4) Kepuasan kerja berpengaruh positif dan tidak signifikan terhadap kinerja karyawan (5) Lingkungan kerja berpengaruh positif dan signifikan terhadap kepuasan kerja (6) Kepemimpinan islami berpengaruh positif dan signifikan terhadap kepuasan kerja (7) Budaya organisasi islami berpengaruh negatif dan signifikan terhadap kepuasan kerja (8) Kepuasan kerja tidak mampu memediasi pengaruh lingkungan kerja terhadap kinerja karyawan (9) Kepuasan kerja tidak mampu memediasi pengaruh kepemimpinan islami terhadap kinerja karyawan (10) Kepuasan kerja tidak mampu memediasi pengaruh budaya organisasi islami terhadap kinerja karyawan.
Factors that Influence Students' Interest in Investing in Cryptocurrency (Case Study of Management Study Program Students, Faculty of Economics and Business, Wiraraja Madura University)
Authors: Ramadhani Moch. Darma Wahyu , Andrianingsih Very
Published: November 2024

Students of the Management Study Program, Faculty of Economics and Business, Wiraraja Madura University, participated in this research in 2019, 2020, and 2021. The study examined the impact of knowledge, return, risk, technological advancement, and minimum capital on interest in cryptocurrency investment. Ini adalah jenis penelitian comparative causal. menggunakan sampel seratus siswa. Sample determination was done using the purposive sampling technique. Multiple linear regression analysis was the data analysis technique used. Hasil penelitian menunjukkan bahwa faktor pengetahuan dan risiko memengaruhi minat siswa dalam investasi cryptocurrency sebagian. Meskipun demikian, keinginan siswa untuk berinvestasi dalam cryptocurrency tidak dipengaruhi oleh variabel keuntungan, kemajuan teknologi, atau modal minimum. Knowledge, return, risk, technological advancement, and minimum capital
Hidratante multifuncional para as mãos com manteiga de karité
Authors: Soares Yasmin Maria Oliveira , Tescarollo Iara Lúcia
Published: November 2024

As mãos são as partes do corpo mais expostas aos agentes agressivos tais como água, detergentes alcalinos e fatores climáticos como frio e o vento, podendo ocorrer o ressecamento, descamação, fissuras, inflamação e infecções. Com a finalidade de prevenir ou corrigir esses efeitos, formulam-se cosméticos baseados na manutenção da hidratação e na cobertura lipídica protetora da pele, além de restabelecer o pH fisiológico. Hidratantes são classificados de acordo com o mecanismo de ação de seus componentes em oclusivos, umectantes e emolientes. Este estudo teve como objetivo desenvolver um hidratante para as mãos à base de manteiga de karité. O produto foi elaborado seguindo os procedimentos farmacotécnicos para obtenção de uma emulsão cremosa. A fase oleosa foi constituída pela manteiga de karité, emulsificante não iônico, óleo mineral, propilparabeno e butilhidroxitolueno. A fase aquosa foi constituída por glicerina, metilparabeno, edetato dissódico e água purificada. A fase termolábil foi composta constituída pela essência de rosas, dexpantenol, ácido hialurônico e o extrato glicólico de calêndula. O hidratante desenvolvido se apresentou agradável ao toque, com características farmacotécnicas adequadas diante do objetivo da pesquisa. Outros estudos devem ser conduzidos para atestar a estabilidade e eficácia na hidratação e cuidado das mãos.
Cannabis no Vale do Rio Branco: Rotas e Difusão Histórica no Norte da Amazônia
Authors: Barbosa Reinaldo Imbrozio , Briglia‐Ferreira Sylvio Romério , Citó Arthur Camurça , Fonseca André Augusto da
Published: November 2024

O livro "Cannabis no Vale do Rio Branco" é um ensaio exploratório que toma como base hipotética que a Cannabis (psicoativa = inebriante e não-psicoativa = comercial) tenha tido duas possíveis rotas protagonizadas por diferentes atores no extremo norte da Amazônia Brasileira: (i) Rota Essequibo-Rupununi – através de diferentes atores vinculados à escravidão (negra e indígena) e à exploração econômica das Colônias europeias (Holanda e Inglaterra) estabelecidas no litoral caribenho das Guianas, com passagens pelas regiões fronteiriças com o Brasil, e (ii) Rota Amazonas-Negro – com atores vinculados à população indígena e/ou a degredados das insurreições de populações racializadas, como mestiços, negros e indígenas derivados da região da Barra do Rio Negro ou vilas adjacentes que se refugiaram ou que tiveram sua passagem marcada por povoados coloniais no rio Branco. A descrição das rotas buscou evitar estigmas ou visões estereotipadas sobre os atores na difusão da Cannabis no Vale do Rio Branco, inferindo o debate nos contextos temporais e nas descrições dos hábitos e costumes oferecidos pelas fontes etno-históricas.
Caminhar, transitar, transgredir pela Linguística aplicada crítica e decolonial
Authors: Costa Alan Ricardo , Silva Júnior Antonio Ferreira da , Zambrano Cora Elena Gonzalo , Silva Marcus Vinícius da
Published: November 2024

Em outubro de 2022, na Universidade Federal de Roraima (UFRR), foi realizada a primeira edição da Jornada de LA, um evento inicialmente tímido, com o objetivo de estabelecer diálogos e construções de conhecimentos sobre a linguagem como prática social. Os dois dias de jornada, com mesas redondas e simpósios de comunicações orais, foram suficientes para a confirmação de que tínhamos como local de fala uma mesma LA: indisciplinar, crítica, transgressiva (Moita Lopes, 2006; Finardi et al., 2019; Leffa et al., 2020) e alinhada com os estudos decoloniais (Mignolo, 2008; Walsh, 2013), fortemente presentes na agenda de pesquisa nacional (Bock; Menezes de Souza, 2019; Jordão et al., 2023). Ao mesmo tempo, de forma quase paradoxal, notamos que tínhamos um mesmo local de fala, mas também cada um o seu: o coletivo de trabalhos apresentados indicava uma variedade de temas, teorias, métodos e objetos de pesquisa, não de forma individual, mas com inegável potencial de conexão e colaboração em rede. A diversidade na unidade, a singularidade na pluralidade.

No ano seguinte, em 2023, a Jornada de LA foi realizada na Universidade Estadual de Roraima (UERR), confirmando seu caráter itinerante (ou, também podemos dizer, migrante). O número de participantes e de público duplicou. A partir das experiências prévias de eventos on-line, construímos uma programação híbrida, o que possibilitou a interação com docentes, pesquisadores e estudantes de todas as regiões do Brasil. A jornada, até então local e regional, assumia ares de evento glocal, para mobilizar um construto hoje bastante popular na área (Celani, 2016). O amálgama das palavras global e local, neste caso, refere-se às interações complexas na pesquisa em LA de forma ampla, que nutria - mas também era nutrida - pelas pesquisas locais.

O saldo positivo dessa segunda edição, bem como os diálogos que começaram (mas não se esgotaram) nas mesas e nos simpósios temáticos foram as faíscas responsáveis por gerar o calor e a energia que movem o presente livro. Convidamos colegas e parceiros de diferentes regiões para participar desta obra, cujo escopo contempla temáticas tais quais: processos de ensino e de aprendizagem de línguas em diversos contextos, formação de professores, translinguagem, transculturalidade e decolonialidade nos estudos linguísticos e na educação linguística contemporânea, questões de gênero e/ou raça, políticas linguísticas, dentre outras pautas caras à área.

O resultado é esta obra, composta por 10 capítulos que dialogam entre si e estão em sinergia com a atual agenda de pesquisa da Linguística Aplicada, indisciplinar, híbrida, mestiça e decolonial. Fazemos votos de que a obra seja o início de outros processos, um convite a cada leitor para também caminhar, transitar e transgredir pelos temas e problemas de pesquisa abordados nas páginas que seguem.
Warao Janoko Emo: Uma década da diáspora dos indígenas refugiados venezuelanos para o Brasil
Authors: Cirino Carlos Alberto Marinho , Lima Carmen Lúcia Silva , Muñoz Jenny González
Published: November 2024

A coletânea "Warao Janoko emo: uma década da di´aspora dos indígenas refugiados venezuelanos para o Brasil" vem dar continuidade às reflexões feitas em três publicações anteriores, que são resultado das pesquisas realizadas, principalmente, na região Norte e Nordeste, por uma rede de pesquisadores que vem acompanhando à diáspora dos Warao desde 2014, quando entraram no Brasil pela área fronteiriça do estado de Roraima. A coletânea traz uma série de artigos demonstrando uma sensibilidade e o senso humanitário dos pesquisadores diante dos graves problemas enfrentados pelos Warao nos diversos estados brasileiros.
Meningkatkan Literasi Digital Melalui Pengintegrasian Pembelajaran Bahasa Bali: Tinjauan Persepsi Siswa di Sekolah Dasar No. 6 Kuta
Authors: Priantara I Made Ari
Published: November 2024

Pemanfaatan teknologi digital semakin meluas di berbagai aspek kehidupan, termasuk dalam dunia pendidikan. Di Indonesia, pelestarian budaya lokal, seperti Bahasa Bali, memiliki peran penting. Literasi digital menjadi alternatif menarik yang perlu dieksplorasi, terutama karena keterampilan Bahasa Bali memiliki relevansi signifikan dalam era digital saat ini. Pembelajaran Bahasa Bali dalam konteks literasi digital menimbulkan relevansi substansial dalam persiapan generasi muda menghadapi tantangan dan peluang di era digital yang tersedia. Namun, integrasi Bahasa Bali dalam konteks literasi digital di Sekolah Dasar No. 6 Kuta menimbulkan sejumlah tantangan yang memerlukan penyelesaian yang cermat. Strategi digital antara siswa juga menyusul akses terhadap teknologi yang terintegrasi. Oleh karena itu, diperlukan strategi yang efektif untuk meningkatkan pengintegrasian Bahasa Bali dalam literasi digital, dengan pendekatan holistik dan terpadu serta pengembangan bahan ajar yang terintegrasi dengan literasi digital. Hasil penelitian menunjukkan bahwa pengintegrasian pembelajaran Bahasa Bali dapat meningkatkan literasi digital di Sekolah Dasar No. 6 Kuta, dengan implikasi penting yang dapat membentuk arah kebijakan pendidikan dan praktik pengajaran.
ANALISIS LINGUISTIK KLINIS: GANGGUAN BERBAHASA PADA PENYANDANG SUMBING DI MEDIA SOSIAL TIKTOK @ORANGKAMPUNGATM2 PERSPEKTIF BAHASA SUNDA
Authors: Alhafidz Zidan Rizka
Published: November 2024

This study analyzes language disorders in individuals with cleft lip and palate from a phonological perspective, using a case study of the TikTok account @orangkampungatm2 in the context of the Sundanese language. A qualitative narrative approach was used as the methodological framework, with data collection through observation and note-taking of videos uploaded by the subject of the study. The analysis results show that the cleft condition affects the individual's phonetic abilities, particularly in the articulation of bilabial, nasal, and fricative sounds in Sundanese. These sound distortions are caused by the subject's inability to fully close their lips due to the cleft in the lip area. Furthermore, cleft lip and palate also impact suprasegmental aspects such as intonation and prosody (stress). These findings highlight the linguistic challenges faced by individuals with cleft lip and palate and the role of social media in raising public awareness of linguistic diversity. This study contributes to the development of more effective and inclusive intervention strategies in education and speech therapy for individuals with cleft lip and palate.
Analisis Bahasa dan Nilai Puisi “Basa Bali” Oleh Suntari Pr.
Authors: Astuti Ida Ayu Dewi
Published: November 2024

The Balinese poem entitled Basa Bali, created by Suntari Pr in 1959, was a milestone in the birth of modern Balinese poetry. This poem is full of values ​​and meaning, both implicitly and explicitly. This research aims to describe the form and translation, language studies and values ​​of Basa Balinese poetry. This research uses a qualitative approach. The data source comes from Balinese poetry entitled Basa Bali which was obtained through literature study which was then analyzed to obtain data presented in descriptive form. The results of this research are that Balinese basa poetry uses Balinese alus, free rhythm, uses five metaphors and uses Balinese language objects as symbolism. The values ​​contained in this poetry include moral values, social values, cultural values ​​and religious values.
DEVELOPING “BLOOKET” AS A MEDIUM TO ENRICH STUDENTS’ VOCABULARY FOR THE SEVENTH GRADERS
Authors: Laili Masruroh
Published: November 2024

Vocabulary plays a crucial role in English language acquisition. Presently, the predominant challenge in Indonesia is that a significant number of students struggle to communicate proficiently in English due to their insufficient command of vocabulary. Consequently, devising effective strategies to impart vocabulary is crucial. One viable approach to address this challenge involves the utilization of media. Blooket, a computer-based medium, has been transformed into a potent educational tool employing the Research and Development (R&D) framework. R&D, as a research design, is instrumental in the creation and evaluation of new products through iterative experimentation. The research design encompasses key stages, including the validation of materials and media, as well as field assessments. Field evaluations were undertaken at a chosen Junior High School in Sidoarjo, with seventh-grade students participating in the study. The topic selected for enriching students' vocabulary was descriptive text. The primary aim was to ascertain the viability of implementing the developed media and gauge the perceptions of both educators and students during its application. Based on the outcomes derived from the implemented stages, it is evident that Blooket is well-suited for English language instruction. Not only does the game serve as a motivational tool for students, but it also mitigates the risk of student boredom during vocabulary learning sessions.
DETERMINAN BRAND LOVE PADA KONSUMEN WARDAH KOSMETIK
Authors: Ramadhani Sarah , Damayani Alfina , Farhah Maulida Nur , Kristaung Robert
Published: November 2024

Purpose - This study aims to try to determine the effect of Brand Trust, Brand Experience, and Brand Image as independent variables on Brand Love as the dependent variable of Brand WARDAH Cosmetics..
Desgin/Methodology/Approcah - The sample of this research were collected by using the sampling method. The unit of analysis of this study was obtained through distributing questionnaires with a sample of 65 female respondents with student status who had bought and used WARDAH cosmetics. Factor Loading Analysis, Cronbach's Alpha analysis, and Structural Equation Modeling (SEM) were used to examine the relationship between variables in the research model with SPSS 26 and AMOS 23 software.
Finding - The results showed that Brand Trust had a significant positive effect on Brand Love, Brand Experience had a significant positive influence on Brand Love, and Brand Image had a significant positive influence on Brand Love.
 
Abstrak
Tujuan - Penelitian ini bertujuan untuk mencoba mengetahui pengaruh Brand Trust, Brand Experience, dan Brand Image sebagai variabel independen terhadap Brand Love sebagai variabel dependen Brand WARDAH Cosmetics
Desain/Metodologi/Pendekatan - Data penelitian ini dikumpulkan dengan menggunakan metode sampling. Unit analisis penelitian ini diperoleh melalui penyebaran kuesioner dengan jumlah sampel sebanyak 65 responden wanita dengan status mahasiswa yang pernah membeli dan menggunakan kosmetik WARDAH. Analysis Factor Loading, analysis Cronbach’s Alpha, dan Structural Equation Modeling (SEM) digunakan untuk menguji hubungan antar variable dalam model peenelitian dengan software SPSS 26 dan AMOS 23
Hasil Penelitian - Hasil penelitian menunjukkan bahwa Brand Trust beperngaruh positif siginifikan terhadap Brand Love, Brand Experience beperngaruh positif siginifikan terhadap Brand Love, dan Brand Image beperngaruh positif siginifikan terhadap Brand Love
NEW TRENDS IN THE LEVEL OF PRE-UNIVERSITY PREPARATION IN MATHEMATICS
Authors: GRUZDKOV A. , SLOBODINSKAYA T.
Published: November 2024

An analysis of the latest results of the entry diagnostic test of firstyear students shows that the explicit growth of indicators observed in 2014-2020 was followed by a noticeable decrease. There are various explanations of this negative trend: the delayed influence of distance learning during the pandemic, changes in the rules of admission to universities, significant transformations in the secondary education system in previous years. Changes in the structure of readiness for studying at the university are also considered. The most problematic parts of elementary mathematics was to be determined. It was revealed that the tasks of trigonometry demonstrate a decrease in the contribution to the general score of the test.
SPECIAL COURSES AT TECHNICAL UNIVERSITY: DIFFICULTIES WITH THE MATHEMATICAL APPARATUS
Authors: KRIVENKO I.V. , SMIRNOVA M.A. , ISPIRYAN S.R. , IVANOV G.N.
Published: November 2024

The work is devoted to the problem of using mathematical apparatus by students of technical universities studying such special courses as "Equations of mathematical Physics", "Special chapters of physics", "Electrodynamics", within which technical and technological physical phenomena are considered. There is a low level of residual knowledge in mathematics of students by the time they start studying special courses: students do not have enough knowledge of methods and techniques of mathematical operations, as well as the corresponding conceptual apparatus. For the effective assimilation of mathematical concepts, it is proposed to reveal their essence in 1-2 courses when studying physics using accessible and simple examples, controlling the development of the material through testing in ELearning as part of independent work.
DEVELOPMENT OF A RECOMMENDER SYSTEM FOR THE SELECTION OF LITERATURE
Authors: OSIPOVA Y.D. , KANEVA O.N.
Published: November 2024

The article discusses the design and implementation of building recommendations in the web application of an online library. Such methods of building recommendations as content and collaborative filtering and possible options for their implementation are being investigated. Among the options studied are machine learning methods such as clustering and regression, represented by thematic modeling and prediction of pre-readings, and the article describes the algorithms underlying each of the selected methods, as well as presents the results of the obtained models. The developed solution is implemented as an online library service and helps users to find the literature they are interested in among the books posted on the resource.
FORECASTING THE VOLUME OF ELECTRICITY CONSUMPTION BASED ON STATISTICAL DATA
Authors: SHAMARA N.O. , FEDOROV I.V.
Published: November 2024

The article discusses the use of LSTM neural networks for predicting electricity consumption. Data on electricity consumption over several years were used to train and test the model. Experiments with various parameters of the neural network, such as the number of neurons and the depth of data history, were conducted to improve the forecasting accuracy. The results showed that the LSTM neural network provides high accuracy in predicting electricity consumption based on statistical data. These results can be useful for energy companies and government agencies involved in forecasting and planning energy needs.
DEVELOPMENT OF A SOFTWARE PACKAGE FOR ANALYZING INTERNAL SECURITY THREATS OF WINDOWS OS
Authors: PUCHKO V.A. , MOISEEVA N.A.
Published: November 2024

Nowadays most of user mode operating system security threats are being detected by modern antivirus software quite easy, therefore malware developers are often using vulnerabilities in Windows Kernel for making their software much harder to detect as well as gain full control over operating system. One of the main Kernel vulnerabilities, which cannot be fully patched because of how Windows Kernel implemented is dynamic code execution which bypasses Microsoft’s strict requirements for Kernel Software Developers. This article discusses possible ways to detect the execution of such code, as well as the concept of developing a solution for monitoring the execution of potentially malicious code in Windows Kernel.
USING A GENETIC ALGORITHM IN THE SOLUTION TRAVELING SALESMAN TASKS
Authors: SKOMOROSHCHENKO D.A. , FEDOTOVA I.V. , KALIBERDA E.A.
Published: November 2024

This paper describes genetic algorithm approach specific in travelling salesman problem. In paper showed brief genetic algorithm structure. Implemented common genetic algorithm structure in software library and implemented tsp specific operators. Analyzed efficiency of different operators, provided comparison graphs.
MODELING OF THE EDUCATIONAL PROCESS INTRODUCING A STUDENT INTO PROJECT ACTIVITIES
Authors: SPIROVA M.S. , KANEVA O.N.
Published: November 2024

The work is devoted to the analysis of the current state of project activity at the university and modeling the process of launching first-year students into this type of activity. A training program has been developed that contains the necessary materials for the implementation of project activities. Materials have been prepared for the immersion of students in the theoretical part and a scheme for the implementation of the program focused on the practical training of students in the framework of a semester course at the university has been proposed.
UPDATED EDITION OF THE NATIONAL STANDARD GOST R "THERMAL GAS CONSUMING UNITS. INDUSTRIAL GAS BURNERS. LIMIT STANDARDS FOR NOX CONCENTRATIONS IN COMBUSTION PRODUCTS"
Authors: GAAK A.V.
Published: November 2024

The article discusses issues related to updating the edition of the national standard GOST R «Thermal gas-consuming units. Industrial gas burners. Limit standards for NOx concentrations in combustion products.» The draft national standard GOST R was developed within the framework of the approved national standardization program for 2024 TK 244 «Stationary energy equipment» in accordance with the National Standardization Program for 2024. Compliance with the requirements of technical regulations is regulated by the Customs Union «On the safety of devices operating on gaseous fuels» (TR CU 016/2011), paragraph 86 of the List of international and regional (interstate) standards, and in their absence - national (state) standards, as a result the use of which on a voluntary basis ensures compliance with the requirements of the technical regulations of the Customs Union «On the safety of devices operating on gaseous fuels» (TR CU 016/2011) and paragraph 85.
Pengembangan Skala Kesiapan Belajar Mandiri (Self-Directed Learning Readiness / SDLR)
Authors: Pravesti Cindy Asli , Mufidah Elia Firda
Published: November 2024

Saat ini, individu telah memiliki bekal dalam pembelajaran daring (online). Untuk itu penting mengetahui kesiapan belajar mandiri (self-directed learning readiness) dari individu tersebut. Pengetahuan mengenai kesiapan belajar mandiri tentunya diperlukan alat ukur. Hal ini bertujuan untuk mengahasilan skala pengukuran self-directed learning readiness yang valid dan reliabel. Metode penelitian menggunakan metode penelitian dan pengembangan (reaserch and development) yang mengadaptasi dari model penyusunan skala psikologi dengan 9 tahapan yakni identifikasi tujuan ukur, membatasi domain ukur, menghimpun indikator, menulis item skala, uji coba bahasa, uji coba skala, mengukur reliablitias mengukur validitas, dan menyusun kembali skala. Hasil penelitian diperoleh skala Self-Directed Learning Readiness yang valid (> 0,5) dan reliabel (0,6). Selain itu, skala yang dihasilkan juga sudah lolos dalam uji bahasa. Adapun skala self-directed learning readiness ini dapat digunakan sebagai acuan bagi konselor dalam upaya pencegahan mengenai kemandirian belajar.AbstractCurrently, individuals are equipped with online learning. For this reason, it is important to know the individual's self-directed learning readiness. Knowledge regarding readiness for independent learning certainly requires measuring tools. This aims to produce a self-directed learning readiness measurement scale that is valid and reliable. The research method uses the research and development method which is adapted from the psychological scale construction model with 9 stages, namely identifying measuring objectives, limiting the measuring domain, collecting indicators, writing scale items, language testing, scale testing, measuring reliability, measuring validity, and rearranging the scale. The research results obtained a self-directed learning readiness scale that was valid (> 0.5) and reliable (0.6). Apart from that, the resulting scale has also passed the language test. The self-directed learning readiness scale can be used as a reference for counselors in preventing independent learning
Comparative analysis of clinical and metabolic parameters in patients with dyslipidemia in obesity and type 2 diabetes mellitus
Authors:   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Mikaelyan A.A. , Kislyak O.A. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Mikaelyan N.P. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Komarov O.S. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Terentev A.A. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Gurina A.E. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: November 2024

Purpose. To analyze disturbances in clinical and metabolic parameters in patients with dyslipidemia with impaired composition and function of fatty acids (FA), impaired structure and function of cell membranes in obesity and type 2 diabetes mellitus (T2DM) with insulin resistance, complicated by arterial hypertension (AH) and diabetic cataracts (DC).

Material and methods. In 65 patients aged 38 to 63 years with grade I–II obesity and T2DM, a comprehensive study of the condition of the eye lens, the lipid composition of serum and blood cell membranes, the level of FA in erythrocytes, the degree of lipid peroxidation, and the content of enzymes of antioxidant defense system and glucose utilization by erythrocytes was performed. 65 patients were examined, including: 22 patients aged 39–56 years with type 2 diabetes, 26 patients aged 40–63 years with grade I–II obesity and 17 patients with metabolic syndrome. The control group included 20 patients without endocrine pathology.

Results. In patients with obesity and T2DM structural and functional disorders of erythrocyte membranes were revealed: an increase in the microviscosity of the lipid bilayer of membranes, changes in the structure of membrane-bound proteins, correlating with indicators of glucose-insulin homeostasis and the level of lipid peroxidation, the development of DC, as well as with severe hypertension. In T2DM, the changes were more significant.

Conclusion. All information mentioned is the basis for prescribing adequate therapy aimed to eliminate oxidative stress and other metabolic defects in the membrane-receptor apparatus of blood cells, as well as hypertension due to impaired insulin-dependent vasodilation in conditions of hyperinsulinemia (i.e., due to blockade of the vasodilating effect of insulin). The initiating factor for lens opacification in cataracts, T2DM and obesity is, apparently, a shift in osmolarity in the membrane cells of the lens fibers as a result of the accumulation of insoluble forms of sorbitol, fructose and protein aggregates in them.

Key words: obesity, diabetes mellitus type 2, metabolic syndrome, arterial hуpertension, insulin resistance, diabetic cataract, senile cataract
Application of artificial intelligence in prevention of myopia progression. Solving the problem
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation, Markova E.Y. , Belikova T.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation, Kechin E.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation,   Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation, Shikhalieva E.A. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation, Postolnik A.A. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation, Nikitina A.E. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation, Navruzalieva D.Y. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation
Published: November 2024

Abstract

Application of artificial intelligence in prevention of myopia progression. Solving the problem

E.Yu. Markova, T.V. Belikova, E.V. Kechin, E.A. Shikhalieva, A.A. Postolnik, A.E. Nikitina, D.Ya. Navruzalieva

The S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation2
Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation

This literature review reflects current possibilities of using artificial intelligence in relation to the prediction and treatment of myopia. Artificial intelligence is applicated in various fields of medicine, using digital data.

Over the past few years, machine learning-based methods have shown excellent results in analyzing and detecting patterns in various data. With the help of artificial intelligence, it is possible to improve the efficiency of the healthcare system and reduce the workload and volume of routine clinical work.

Given the size, especially for a complex disease such as myopia, where numerous co-dependent factors are involved in the causes, epidemiology, diagnosis and progression, it is almost impossible to manually analyze clinical data. Machine learning methods make it possible to predict development of a high degree of myopia in adolescents, which may be useful for early detection of children at risk and timely intervention.

Key words: myopia, artificial intelligence, machine learning
Effect of copper on ornamental plants Agrostis stolonifera L., Centaurea cyanus L., Godetia grandiflora Lindl.
Authors: Gladkov† Evgeny Aleksandrovich , Gladkova† Olga Victorovna , Dolgikh Yuliya Ivanovna
Published: November 2024

Ornamental plants are widely used in horticulture and urban greening. However, when plants are used in urban greening, it is necessary to select varieties with increased tolerance to urban conditions. Copper is one of the most toxic metals to plants, so the assessment of plant resistance to copper is important for urban environments. High sensitivity of the studied plants to copper was shown. Godetia grandiflora is the most resistant to copper among the species studied. Agrostis stolonifera and Centaurea cyanus had comparable resistance to copper. The effect of copper on calli of Agrostis stolonifera was also studied.
Устойчивое развитие предприятий железнодорожного транспорта при переходе на сжиженный природный газ
Authors: А.А. Медведева , А.А. Зайцев
Published: November 2024

Повышение энергетической эффективности промышленного сектора экономики России является актуальной темой на сегодняшний день, а также главным фактором достижения устойчивого развития предприятий. Проблема обновления подвижного железнодорожного транспорта стоит очень остро, необходимо либо обновлять полностью устаревающий и неэкологичный состав, либо разрабатывать проекты модернизации. В этом ракурсе модернизация тепловозов на СПГ в качестве моторного топлива очень перспективна. В работе представлены основные результаты разработанной технико-экономической модели переоборудования тепловоза на использование СПГ. В модели приняты определённые теоретические допущения, которые требуется уточнять при разработке практической модели реального локомотива. Результаты модели доказывают положительный экономический эффект, получение экономии на сокращении стоимости жизненного цикла локомотива и окупаемости понесенных затрат. Переход на СПГ будет способствовать достижению устойчивого развития транспортных предприятий, улучшая показатели декарбонизации промышленности.

Increasing energy efficiency of the industrial sector of the Russian economy is a hot topic today, and also the main factor in achieving sustainable development of enterprises. The problem of renovating mobile railway transport is very acute; it is necessary either to update a totally obsolete and non-ecological train, or to develop modernization projects. From this perspective, the modernization of diesel locomotives using LNG as a motor fuel is very promising. The paper presents main results of the developed technical and economic model for the conversion of a diesellocomotive to use LNG. The model makes certain theoretical assumptions that need to be clarified when developing a practical model of a real locomotive. The results of the model prove a positive economic effect, obtaining savings from reducing the cost of the locomotive’s life cycle and recoupment of the costs incurred. The transition to LNG will contribute to achieving sustainable development of transport enterprises, improving the decarbonization of industry.
НОРМАТИВНОЕ РЕГУЛИРОВАНИЕ ВНЕДРЕНИЯ ТЕХНОЛОГИЙ ИСКУССТВЕННОГО ИНТЕЛЛЕКТА В РОССИЙСКОМ ОБРАЗОВАНИИ
Authors: Л.С. Илюшин , Н.А. Торпашёва
Published: November 2024

Ускоряющееся развитие технологий искусственного интеллекта в последние годы обуславливает актуальную потребность в поиске новых юридических решений и нормативного регулирования, особенно в контексте образования. В статье представлен анализ нормативно-правовых актов РФ, связанных с понятием искусственного интеллекта и цифровизации школьного образования. Среди методов исследования используются методы анализа, сравнения и синтеза.

The accelerated development of artificial intelligence technologies in recent years has created an urgent need for new legal solutions and regulatory frameworks, especially in the context of education. The article presents analysis of legal acts of the Russian Federation related to the concept of artificial intelligence and digitalization of school education. As a research method the authors use methods of analysis, comparison and synthesis.
ЦИФРОВЫЕ ОСНОВЫ ОРГАНИЗАЦИИ ЭКОНОМИЧЕСКОГО МЕХАНИЗМА УСТОЙЧИВОГО РАЗВИТИЯ СУБЪЕКТОВ МАЛОГО ПРЕДПРИНИМАТЕЛЬСТВА В РЕГИОНАЛЬНОЙ ИННОВАЦИОННО-ПРЕДПРИНИМАТЕЛЬСКОЙ ЭКОСИСТЕМЕ
Authors: Е.Г. Пашковская
Published: November 2024

В статье представлен разработанный автором научно-практический инструментарий применения цифровых технологий с акцентом на «больших данных» для обеспечения эффективного функционирования экономического механизма устойчивого развития субъектов малого предпринимательства (СМП) в региональной инновационно-предпринимательской экосистеме (РИПЭ). С помощью системного подхода определены цифровые основы функционирования и взаимодействия экономических механизмов РИПЭ и СМП на основе большого (для РИПЭ) и малого (для СМП) циклов BigData.

We present our own scientific-practical tools of applying digital technologies oriented at big data to ensure effective performance of the economic mechanism of sustainable development of small business subjects in regional innovation entrepreneurial ecosystem. Relying on system approach we determine the digital foundations for the functioning and interaction of the economic mechanisms in question based on the big cycle (regional innovation entrepreneurial ecosystem) and small cycle (small business subjects) of BigData.
ТЕОРЕТИКО-ПРАВОВЫЕ ОСНОВЫ ПРИМИРИТЕЛЬНЫХ ПРОЦЕДУР В ГРАЖДАНСКОМ ПРОЦЕССЕ КАК СОСТАВЛЯЮЩАЯ ПРАВОЗАЩИТНОГО МЕХАНИЗМА
Authors: Е.М. Смирнова , Г.Х. Гуменюк
Published: November 2024

В статье проанализирована теоретико-правовая конструкция примирительных процедур в гражданском процессе через рассмотрение правовой конструкции понятия примирительных процедур как полностью соответствующих доктринальному воззрению к пониманию примирительных процедур с точки зрения предопределения применения конкретных примирительных процедур.

The article provides analysis of theoretical and legal construction of conciliation procedures in Civil process through examining legal construction of conciliation procedures as completely corresponding to the doctrinal viewpoints dealing with understanding conciliation procedures from the point of view of predetermination of applying certain conciliation procedures.
HEPOM: Using Graph Neural Networks for the accelerated predictions of Hydrolysis Free Energies in different pH conditions.
Authors: Guha Rishabh D. , Vargas Santiago , Spotte-Smith Evan Walter Clark , Epstein Alexander Rizzolo , Venetos Maxwell , Kingsbury Ryan , Wen Mingjian , Blau Samuel , Persson Kristin A.
Published: November 2024

Hydrolysis is a fundamental family of chemical reactions where water facilitates the cleavage of bonds. The process is ubiquitous in biological and chemical systems, owing to water's remarkable versatility as a solvent. However, accurately predicting the feasibility of hydrolysis through computational techniques is a difficult task, as subtle changes in reactant structure like heteroatom substitutions or neighboring functional groups can influence the reaction outcome. Furthermore, hydrolysis is sensitive to the pH of the aqueous medium, and the same reaction can have different reaction properties at different pH conditions. In this work, we have combined reaction templates and high-throughput ab-initio calculations to construct a diverse dataset of hydrolysis free energies. The developed framework automatically identifies reaction centers, generates hydrolysis products, and utilizes a trained Graph Neural Network(GNN) model to predict values for all potential hydrolysis reactions in a given molecule. The long-term goal of the work is to develop a data-driven, computational tool for high-throughput screening of pH-specific hydrolytic stability and the rapid prediction of reaction products, which can then be applied in a wide array of applications including chemical recycling of polymers and ion-conducting membranes for clean energy generation and storage.
Carbon reduction powered by natural electrochemical gradients under submarine hydrothermal vent conditions
Authors: Altair Thiago , Dragoti Eleftheria-Sofia , Sojo Victor , Li Yamei , McGlynn Shawn , Galante Douglas , Varela Hamilton , Hudson Reuben
Published: November 2024

Energy metabolism at the emergence of life has been the topic of intense theoretical and experimental study. Alkaline hydrothermal vents (AHVs) may have facilitated energy-transfer and carbon-fixation at life’s emergence, via a primordial chemiosmotic mechanism. Specifically, pH separation across vent walls could have been the forerunner to pH separation across microbial membranes, with electron-conductive inorganic barriers containing [Ni-]FeS minerals mimicking the active sites of metalloenzymes in potentially ancient biological reductive acetyl-CoA Wood-Ljungdahl (WL) pathway, reverse Krebs and other metabolic pathways. We previously demonstrated pH gradient dependent reduction of CO2 to formate by H2 in AHV interface conditions. Here, we address the same problem of CO2 reduction, however using a macroscale reactor that allowed us to use minerals synthesized via protocols analogous to the alkaline vent mount formation. This reactor also allowed us to probe more variables, and explore longer experimentation time-frames. Thus, this work aimed to investigate the effect of the different aspects of the gradientrich hydrothermal-vent interface on the observed CO2 electrochemical reduction- such as different minerals, temperature gradients, as well as the flow of electrons under passive vs. induced currents and potentials. Using experimental simulations and electrochemistry techniques, We detected two key steps of the WL pathway (CO2 to formic acid, and the formation acetic acid) as well as reactions in the reverse Krebs cycle (fumarate to succinate). Both Ni in the mineral, and temperature as a property, were shown to affect the formation of formate. Extremely small currents were enough to efficiently carry out CO2 reduction. This work develops benchmarks to electrochemically explore the model of protometabolisms in the vent-ocean interface and opens to future analyses on the catalytic or electrocatalytic properties of Fe-[Ni-]S minerals as precursors of metalloenzymes.
Engineering melanin-based meta-material for broad UV-visible absorption
Authors: Choudhury Arpan , Ghosh Debashree
Published: November 2024

Designing materials with high intensity absorption of solar light across wide wavelength range is a primary goal in organic optoelectronics engineering. However, the potential application of most known biomolecules specifically in bio-optoelectronics is limited because they can only absorb light within specific wavelengths. Both experimental and computational approaches have investigated the potential of the skin pigment melanin, in this direction, but progress has been limited due to the complexity of its chemical space. In this work, we design a comprehensive virtual chemical space of melanin and develop machine learning-based approach to predict their complete optical and thermodynamical properties. These predictions help engineering melanin-based sustainable materials for tailored optoelectronic applications.
Unravelling the Photodissociative Mechanism of CO-Release in Re(I) Tricarbonyl Complex Using Density Functional Theory
Authors: Kumar Prashant , Boggio-Pasqua Martial , Dixon Isabelle
Published: November 2024

The mechanism of the CO ligand dissociation of [Re(CO)3(Pyta)(TPP))]+ complex in aqueous medium has been investigated theoretically, as the dominant process of the photochemical ligand substitution (PLS) reaction of [Re(CO)3(Pyta)(TPP))]+, by using density functional theory (DFT). The PLS reactivity can be determined by the topology of the lowest triplet potential energy surface because the photoexcited complex is able to decay into lowest triplet state via intersystem crossing and internal conversion with sufficiently low energy barriers. The lowest triplet state has a character of metal-to-ligand-charge-transfer (3MLCT) around the Franck-Condon region, and it shifts to metal-centered (3MC) state as the axial Re-CO bond is bend and elongated. The equatorial CO ligand is not dissociated in the course of PLS reaction and only axial CO ligand is selectively dissociated. This study reveals that the 3MC connecting the 3MLCT is not dissociative in nature, rather, the dissociative 3MC is reached via multiple 3MCs. We also predict that the photoproduct [Re(CO)2(CH3CN)(Pyta)(TPP))]+ is formed via the formation of a singlet-adduct. The insights provided in this study shed light on, not-all 3MCs are dissociative in nature, and a step forward towards rationally-designing novel PhotoCORMs.
Structure-Activity Optimization of Phenoxy-1,2-Dioxetane Precursors as Probes for Singlet Oxygen Yields Unprecedented Detection Sensitivity
Authors: Tannous Rozan , Shabat Doron
Published: November 2024

Chemiluminescence imaging has emerged as a powerful alternative to fluorescence-based methods, offering significant advantages such as reduced background noise, elimination of autofluorescence, and prevention of photobleaching. These benefits are particularly critical for singlet oxygen detection, where excitation light in fluorescence techniques can inadvertently generate singlet oxygen, compromising measurement accuracy. Despite this potential, the development of highly sensitive chemiluminescent probes for singlet oxygen detection under physiological conditions remains an urgent challenge. Here, we present a comprehensive structure-activity optimization of phenoxy-1,2-dioxetane precursors as probes for singlet oxygen detection in biologically relevant environments. By systematically evaluating key parameters—steric hindrance at the oxidation site, the chemiexcitation rate of the luminophore, and total light emission, we significantly increased the detection sensitivity of the singlet oxygen probe. Notably, a cyclobutyl-enolether probe (SOCL-CB) and a dimethyl-enolether probe (SOCL-DM) demonstrated 57-fold and 118-fold higher signal-to-noise (S/N) ratios, respectively, compared to the previously reported chemiluminescent adamantyl-enolether probe (SOCL-AD). The superior detection sensitivity of probe SOCL-DM was validated in an enzymatic model where singlet oxygen production was mediated by horseradish peroxidase. Remarkably, probe SOCL-DM detected singlet oxygen concentrations as low as 127 nM in this system, outperforming the previously reported probe SOCL-AD. These results establish SOCL-DM as the most sensitive chemiluminescent probe for singlet oxygen detection under physiological conditions reported to date. This study underscores the potential of chemiluminescent probes like SOCL-DM to facilitate real-time monitoring of singlet oxygen, providing invaluable tools for studying oxidative stress, elucidating cellular processes, and advancing diagnostic applications.
Effect of Ground Stack for Additional Internal Force and Deformation of Underground Pipeline
Authors: Xiong Hongyuan
Published: November 2024

Based on a three-dimensional finite element model of an underground pipeline, the influence of additional ground loads on the stress characteristics of the pipeline was studied. Furthermore, the effects of different soil properties, load locations, and varying burial depths on the pipeline’s stress characteristics were analyzed. The research results show that as the distance between the load center and the pipeline axis increases, the positions of the pipe’s maximum displacement, bending moment, and shear force along the axis decrease significantly. However, when this distance reaches a certain value, the pipeline’s maximum vertical displacement and internal forces approach zero. Different pipelines exhibit minimum values of maximum axial displacement and vertical displacement in soft soil, while maximum axial displacement occurs in clay, and the largest vertical displacement is observed in sandy soil. The maximum axial displacement of UPVC pipes in clay is twice that of soft soil. The vertical displacement of pipes made from different materials increases with burial depth, but for concrete and steel pipes, the maximum axial tension increases significantly with depth, whereas the change in UPVC pipes is more gradual.
Review of Key Technologies and Applications in Intelligent Transportation Systems
Authors: Diao Hanlou , Shen Wei
Published: November 2024

The development of Intelligent Transportation Systems (ITS) is closely intertwined with the growth of every city, serving as a critical component of smart city construction. This paper provides a concise overview of the concept and overall framework of smart transportation. It emphasizes the application of key technologies, including Traffic Element Identification and Perception, data mining, and Smart Transportation System Integration Technology, in the field. Furthermore, the paper elucidates the current practical applications of smart transportation, showcasing its advancements and implementations in real-world scenarios.