bluuebunny/crossref_metadata_2025 huggingface dataset:
Information security of minors: individual subjects of the Russian Federation organization experience
Authors: Titor S. E.
Published: March 2023

The problem of information security of minors does not concern only the federal regulator. It should be provided at all levels of regulation: federal, regional, municipal and local. The basic principles and mechanisms for ensuring the information security of minors are regulated by federal legislation. At the regional level, the mechanisms are being detailed, independent concepts are being developed. This study analyzes the experience of individual subjects of the Russian Federation in ensuring the information security of minors. The following regions were studied: Komi Republic, Perm Krai, Orenburg Region, Republic of Tatarstan. The state of criminalization of minors has been recorded by region. Based on this, regions with an average level of juvenile delinquency have been selected. The work examines regional legislation on the protection of minors from the destructive information environment, regional information security programs. The law enforcement practice is also considered, in particular, increasing the media literacy of adolescents. The participation of regional law enforcement agencies in explanatory work has been studied. The role of volunteer movements in protecting minors from negative information and in educational work is investigated. The positive experience of the regions in protecting children from negative information is highlighted. At the end of the study, conclusions about the translation of positive experience were made.
Why does the UL49.5 of herpes simplex 1 virus fail to inhibit the TAP-dependent antigen presentation?
Authors: Rodziewicz-Motowidło Sylwia , Krupa Paweł , Karska Natalia , Zhukov Igor , Lipińska Andrea
Published: March 2023

Herpes simplex virus type 1 (HSV-1) is a well-studied herpesvirus that causes a number of human diseases. The HSV-1, like other herpesviruses, produces transmembrane glycoprotein N (gN / UL49.5 protein). Although this protein is conserved throughout the herpesvirus family, little is known about its function in HSV-1. The amino-acid sequence and length of UL49.5 proteins differ between herpesvirus species. It is, therefore, crucial to determine whether and to what extent the spatial structure of UL49.5 orthologs that are TAP inhibitors (i.e., of BoHV-1 virus) differs from that of non-TAP inhibitors (i.e., of HSV-1 virus). As a result, the primary goal of our study was to examine the 3D structure of HSV-1-encoded UL49.5 protein in an advanced model of the endoplasmic reticulum (ER) membrane. Circular dichroism (CD), 2D nuclear magnetic resonance (NMR), and multiple-microsecond all-atom molecular dynamics (MD) simulations in the ER membrane mimetic environment were used to determine the final structure of the HSV-1 UL49.5 protein. According to our findings, the N-terminus of HSV-1 UL49.5 adopts a highly flexible, unordered structure in the extracellular part due to the presence of a large number of Pro and Gly residues. In contrast to the UL49.5 protein from BoHV-1, the transmembrane region of HSV-1-encoded UL49.5 is formed by a single long transmembrane -helix, rather than two helices oriented perpendicularly, while the cytoplasmic part of the protein (C-terminus) has a short unordered structure. Our findings provide experimental structural information on HSV-1-encoded UL49.5 protein and structure-based insight into its lack of biological activity in inhibiting the TAP-independent antigen presentation pathway.
Understanding Reactivity and Stability of Rhodium Supported on Different Ceria Facets in Catalytic NO Reduction and CO/Hydrocarbon Oxidation Reactions
Authors: Song Inhak , Szanyi Janos , Wang Yong , Khivantsev Konstantin
Published: March 2023

Fully dispersed rhodium was supported on ceria with varying abundance of facets (100), (101) and (111). The resulting materials were evaluated for NO reduction by CO as well as CO/propylene oxidation under model and industrially relevant conditions. Very pronounced reactivity and stability differences were observed depending on the facet. Rh supported on (111) abundant ceria showed the highest activity and stability for all reactions. TPR and in-situ IR measurements revealed mechanistic details of NO reduction and CO oxidation, highlighting very different modes of interaction of Rh+3 ions on various facets and their contrasting reducibility, resulting in such pronounced catalytic activity changes.
GDB-9-Ex and ORNL_AISD-Ex: Two open-source datasets for quantum chemical UV-vis electronic excitation spectra of organic molecules
Authors: Lupo Pasini Massimiliano , Mehta Kshitij , Yoo Pilsun , Irle Stephan
Published: March 2023

We present two open-source datasets that provide time-dependent density-functional tight-binding (TD-DFTB) electronic excitation spectra of organic molecules. These datasets represent predictions of UV-vis absorption spectra performed on optimized geometries of the molecules in their electronic ground state. The GDB-9-Ex dataset contains a subset of 96,766 organic molecules from the original open-source GDB-9 dataset. The ORNL_AISD-Ex dataset was created from GDB-9 molecular structures using a generative algorithm and consists of 10,502,904 organic molecules that contain between 5 and 71 non-hydrogen atoms. The data reveals the close correlation between the magnitude of the gaps between the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO), and the excitation energy of the lowest singlet excited state energies quantitatively. The chemical variability of the large number of molecules was examined with a topological fingerprint estimation based on extended-connectivity fingerprints (ECFPs) followed by uniform manifold approximation and projection (UMAP) for dimension reduction. Both datasets were generated using a high-throughput workflow that used the DFTB+ software on the Andes' cluster of the Oak Ridge Leadership Computing Facility (OLCF) at Oak Ridge National Laboratory (ORNL).
Insights into Crystal Size and Synthesis Dependent Guest-Induced Flexibility of ZIF-7 Pore Structure
Authors: Bose Rimita , Bon Volodymyr , Bönisch Nadine , Selvam Parasuraman , Kaisare Niket S. , Kaskel Stefan
Published: March 2023

Nano-sized and flexible metal-organic frameworks (MOFs) are highly desirable materials for gas separation. However, the impact of synthesis conditions and crystal size on guest induced structural flexibility in MOFs is not well-understood. We aim to comprehend the effect of crystal size and synthesis conditions on the gate-opening behaviour of ZIF-7 stimulated by incorporation of guest molecules. The synthesis conditions are varied to obtain crystal sizes ranging between 0.05 and 15 m with varying homogeneity. The adsorption of carbon dioxide on ZIF-7 indicates the influence of crystal size and distribution, as well as synthesis conditions on the gate-opening pressure and slope of CO2 adsorption isotherm. We report for the first time an intermediate CO2 filled open pore arrangement of ZIF-7 at 195 K (OP-2) using an in-house in-situ PXRD in parallel with adsorption. In-situ PXRD measurement indicated further expansion of ZIF-7 framework in presence of methanol as guest species. The capability of ZIF-7 to accommodate molecules larger than its 0.3 nm window diameter indicates the importance of intermolecular interactions to overcome the energy barrier for linker movement/breathing of the framework.
SIMPD: an Algorithm for Generating Simulated Time Splits for Validating Machine Learning Approaches
Authors: Landrum Gregory A. , Beckers Maximilian , Lanini Jessica , Schneider Nadine , Stiefl Nikolaus , Riniker Sereina
Published: March 2023

Time-split cross-validation is broadly recognized as the gold standard for validating predictive models intended for use in medicinal chemistry projects. Unfortunately this type of data is not broadly available outside of large pharmaceutical research organizations. Here we introduce the SIMPD (simulated medicinal chemistry project data) algorithm to split public data sets into training and test sets that mimic the differences observed in real-world medicinal chemistry project data sets. SIMPD uses a multi-objective genetic algorithm with objectives derived from an extensive analysis of the differences between early and late compounds in more than 130 lead-optimization projects run within the Novartis Institutes for BioMedical Research. Applying SIMPD to the real-world data sets produced training/test splits which more accurately reflect the differences in properties and machine-learning performance observed for temporal splits than other standard approaches like random or neighbor splits. We applied the SIMPD algorithm to bioactivity data extracted from ChEMBL and created 56 public data sets which can be used for validating machine-learning models intended for use in the setting of a medicinal chemistry project. The SIMPD code and simulated data sets are available under open-source/open-data licenses at github.com/rinikerlab/molecular_time_series.
Web-Based Design of BIPA Placement Test Instrument for Foreign Speakers
Authors: Boeriswati Endry , Ningsih Rahmi Yulia , Rahayu Wardani
Published: March 2023

This study aimed to develop a web-based Indonesian-language placement test instrument for foreign speakers, commonly called BIPA (Bahasa Indonesia bagi Penutur Asing). The research method involved design-based research (DBR) with test instrument development procedures developed by the Association of Language Testers in Europe. The results show that 89% of respondents strongly agreed that the development of a BIPA placement test instrument was very much needed in BIPA learning. To triangulate the data from the interviews and questionnaire, a bibliometric analysis was performed. From the results of the bibliometric analysis, 117 studies were found on foreign-language placement tests in the 2012–2022 range and there was no research on the development of BIPA placement test instruments. The BIPA placement test is designed to measure the level of Indonesian-language skills of foreign speakers, which include listening, reading, writing, and speaking skills. This test can be used by teachers/institutions to determine the level of Indonesian-language skills of foreign speakers, starting from levels A 1, A-2, and B-1. This test is also useful for authorized institutions to provide Indonesian-language certification to foreign speakers who need it. Further research can be done with the development of BIPA test instruments for intermediate and advanced levels.
Manufacturing methods used to produce certain biocomposite materials – a mini-review
Authors:   University of Pitesti, DICU Maria Magdalena , NICOLAE Mirela Iuliana
Published: March 2023

In recent years, interest in biocomposite materials has grown significantly, due to the potential to replace conventional materials. The increasing use of biocomposite materials in various fields (aerospace, automotive, maritime transport, sports equipment, energy, construction, medicine), is due to their characteristics, superior to those of conventional materials, the reduction of energy consumption required for their production, the increased resistance to corrosion, tear resistance, wear resistance, high temperature, strength, low density, controllable thermal conductivity, good deformability, exceptional dimensional stability, low thermal expansion, impact resistance and many other characteristics that, unlike classical materials, are convenient. This study reviews the manufacturing methods used to produce certain biocomposite materials.
Nor da nor Lur Hiztegi Entziklopedikoan? Euskarazko lehenengo entziklopediaren demografia digital alderatua
Authors: Gonzalez Larrañaga Galder , Perez de Viñaspre Garralda Olatz
Published: March 2023

1991n argitaratu zen Lur Hiztegi Entziklopedikoaren helburua euskararen diglosiarekin amaitzea zen, euskarazko entziklopedia orokor eta unibertsal bat eskainiz. Entziklopedia batek helburu unibertsala izateak zer esan nahi duen aztertu dugu, eta helburu hori bete duen edo ez ikertu dugu. OpenRefine eta Wikidata erabiliz, Lur Hiztegi Entziklopedikoan agertzen diren biografia guztiak aztertu eta parekatu ditugu. Horrela, demografia digital bat egiteko aukera izan dugu. Unibertsaltasun-helburu hori bete den edo ez jakiteko, beste entziklopedia orokor batzuekin alderatu ditugu biografia horiek. Emaitzak erakusten du euskarazko lan hau, xumeagoa izanda ere, Europako gainontzeko entziklopedien pare zegoela.
AGHNa duten haurrei bideratutako teknika osagarriak: mindfulness-a, errealitate birtuala eta mindfulness birtuala
Authors: Olarza Goikoetxea Amaiur , Soroa Martinez Goretti , Aritzeta Galan Aitor , Aranberri Ruiz Ainara , Mindeguia Petrirena Rosa
Published: March 2023

Lan honetan, haurren arreta-gabeziaren eta hiperaktibitatearen nahasmendua (AGHN) jorratzeko eraginkorrak izan daitezkeen hiru teknika berritzaile eta osagarri aurkeztu nahi dira: mindfulnessa, errealitate birtuala eta mindfulness birtuala. Horrela, lan hau hiru zati nagusitan banatu da. Lehenik eta behin, AGHNaren kontzeptualizazioa berrikusiko da eta nahasmenduak haurren garapen psikologikoan eragiten dituen zailtasunak aurkeztuko dira. Bigarrenik, aipaturiko hiru teknikak deskribatuko dira eta arlo biopsikosozialean izan ditzaketen onurak laburbilduko dira. Hirugarrenik, AGHNa duten haurren familiei zein irakasleei zuzendutako baliabide eta gomendio batzuk emango dira. Eta amaitzeko, lan honek izan ditzakeen indargune, ahulgune eta etorkizuneko lan-ildoak laburbilduko dira.
Análisis del discurso de los elementos nacionalistas en las películas Chicogrande (2010) y Ciudadano Buelna (2013) de Felipe Cazals
Authors: Frías Luis Gerardo
Published: March 2023

El cine mexicano ha servido como herramienta propagandística desde sus inicios, sobretodo promoviendo el discurso nacionalista en películas de la revolución buscando recalcar un momento histórico de héroes y defensores de la patria. El objetivo principal de esta investigación es analizar los elementos nacionalistas encontrados en los textos cinematográficos de Chicogrande y Ciudadano Buelna, para identificar la forma en que se utiliza el discurso nacionalista. Por lo tanto se realizó el método del análisis cinematográfico propuesto por Aumont y Marie (1990), el cual nos indica que como se ha visto en los últimos años el cine de la Revolución tiende al revisionismo pues todo sucede alrededor del conflicto, la historia se sitúa en personajes que si bien no son los héroes icónicos son cercanos a ellos y un claro ejemplo del discurso nacionalista.
Analysis Of Hazardous Medical Waste In Dr. Soehadi Prijonegoro Hospital Using A Life Cycle Assessment Approach
Authors: Kusuma Adi Bayu , Joko Tri , Setiani Onny
Published: March 2023

Hospitals are health services that produce waste and sources of pollution for human health and the environment. dr. Soehadi Prijonegoro Hospital produces the most medical waste in the sragen regency and still needs cold storage. This research evaluated the management of hazardous toxicity material medical, solid waste. Life cycle assessment calculations can be performed using a software application, simparo 9.0. This scope of research with gate to gate approach. Inventory data was obtained from primary and secondary data collection. Daily medical waste is about 135 kg, while the average month is 3961 kg—medical waste management in dr. Soehadi Prijonegoro includes reducing, sorting, labeling, storage, transporting, and processing have been following applicable regulations. The results of the TCLP test of solids incinerator ash and chimney incinerator emissions meet the quality standards. The most significant impact on the ecosystem is the global warming potential in the emergency service room. For impacts, the natural resources and the impact on the ecosystem is the inpatient room due to excessive use of medical waste. Use of energy and materials to minimize emissions and waste.
Keywords: Hospital, Waste, Impact
Faktor Yang Berhubungan Dengan Keluhan Nyeri Otot Rangka Pada Pemulung Di Lingkungan TPST RDF Kabupaten Cilacap
Authors: Poppi Nastasia Yunita Dewi  , Sofia Rakhmawati Nita , Kartika Estri , Hariyanto Saputro Didit
Published: March 2023

Keluhan nyeri otot rangka merupakan serangkaian sakit atau cedera yang terjadi pada otot, tendon, tulang, ligamen, sendi, dan saraf mulai dari tingkat sangat ringan sampai sangat sakit yang disebut dengan Muskuloskeletal disorders (MSD). Keluhan nyeri otot rangka ini disebabkan oleh aktivitas  dengan tingkat pengulangan yang tinggi dengan cara kerja yang tidak ergonomis. Penelitian ini bertujuan untuk mengetahui hubungan antara jenis kelamin, masa kerja, dan berat beban dengan keluhan nyeri otot rangka pada pemulung. Penelitian ini merupakan penelitian observasional analitik dengan metode pendekatan cross sectional. Hasil penelitian ini menunjukkan bahwa jenis kelamin paling banyak adalah perempuan sebesar 76,7%, masa kerja pemulung ? 5 tahun sebesar 77,1%, berat beban yang berisiko sebesar 10,5% dan keluhan nyeri otot rangka sebesar 63,2%. Analisis uji chi square test menunjukkan terdapat hubungan antara jenis kelamin (p: 0,026), masa kerja (p: 0,006), berat beban (p: 0,001) dengan keluhan nyeri otot rangka pada pemulung di TPST RDF Kabupaten Cilacap. Pemulung diharapkan tidak mengangkut beban sampah yang berlebihan, mengatur jam istirahat, dan menerapkan konsumsi gizi seimbang.
Status of mangrove ecosystems in the waters of Senggarang Besar, Tanjungpinang City, Riau Islands Province
Authors: Salam Muzadid , Lestari Febrianti , Susiana Susiana
Published: March 2023

The waters of Senggarang Besar are located in Senggarang Village, Tanjungpinang Kota District. The waters of Senggarang Besar have a fairly large mangrove ecosystem plus many mangrove seedling planting activities in the coastal waters of Senggarang Besar. Mangrove ecosystems have a variety of natural resources that are abundant and diverse. Mangroves are the most potential ecosystems because mangroves support the diversity of flora and fauna in aquatic communities and play a significant role in human survival based on economic, community and environmental perspectives. This study aims to determine the density, canopy cover, and status of mangrove ecosystems in the waters of Senggarang Besar. This research was conducted in September-December 2022 located in the waters of Senggarang Besar Tanjungpinang City, Riau Islands Province. Determination of observation stations using direct survey method in the field with 3 station points with 6 plots at each station, based on the presence of mangrove ecosystems. Determination of the retrieval point using purposive sampling method. Mangarove ecosystem species found in the waters of Senggarang Besar Tanjungpinang City Riau Islands Province there are 4 species including: Rhizophora apiculata, Bruguiera gymnorhiza, Xylocarpus granatum, and Avicenia marina. With density and cover values at station 1, 3900 ind/ha and 81.00%, at station 2, 1433.33 ind/ha and 69.98%, and station 3, 1446.7 ind/ha and 69.08%. The level of damage to the mangrove ecosystem in the waters of Senggarang Besar Tanjungpinang City, Riau Islands Province at station 1 includes good, very dense criteria based on KepMen LH No. 201 of 2004. While at stations 2 and 3 the level of damage includes good, moderate criteria based on KepMen LH No. 201 Year 2004.
Application of NDVI Transformation on Sentinel 2A Imagery for mapping mangrove conditions in Makassar City
Authors: Faizal Ahmad , Mutmainna Nita , Amran Muh Anshar , Saru Amran , Amri Khairul , Nessa Muh Nastsir
Published: March 2023

Mangrove ecosystems consist of tropical plants that have adapted to the salinity, tidal fluctuations, and loose soil condition. Identification of mangrove ecosystems can be carried out by direct survey methods or by utilizing remote sensing technology. This study aims to map the area, percent cover, and density of mangroves in Makassar City using Sentinel 2A Imagery. The method used is the NDVI transformation, followed by Unsupervised-ISODATA classification, ground check with the 10 x 10-meter plotting method, and hemispherical photography. The results showed that the existence of mangroves in Makassar City was still found in the Tallo and Biringkanaya districts, with 68.81 ha of mangrove ecosystem cover area in the range of 84.36 - 91.89% (dense category). Likewise, the vegetation index based on NDVI analysis ranged from 0.73 - 0.81 (dense category), and the species density was in the range of 2700 - 6400 trees/Ha (dense category). Sentinel-2A imagery transformed with NDVI can be used to track mangrove areas and their density. The wide distribution of mangrove ecosystems in Makassar is relatively small but has good conditions.
MITIGATE TYPE II AGENCY CONFLICT THROUGH GOOD CORPORATE GOVERNANCE AND DISCLOSURE QUALITY
Authors: Jatiningrum Citrawati , Fauzi Fauzi , Utami Bernaditha H.S , Kassim Aza Azlina Md
Published: March 2023

Empirical evidence on type II conflicts between controlling shareholders versus minority shareholders has not been extensively explored.  This study gives new evidence on the agency conflict in a scenario of highly concentrated ownership. This study aims to examine the effect of Good Corporate Governance mechanism with quality of disclosure on concentrated ownership context The sample were drawn from companies listed on the Indonesia Stock Exchange (IDX). The data were analyzed with panel data regression. The results shows that CG mechanisms negatively effects with DQ. However, looking at each individual variable, the study reveals that the audit committee and independence of audit committee are not significant. A possible reason is that companies' audit committee members have lack of accounting expertise and independence. These findings shed light on the concept of good CG enhances incentives for good DQ under highly concentrated ownership. It the effectiveness of CG mechanisms is likely to supplement regulation to protect investor rights and may prove to be useful for standard-setters as an important way to reduce agency conflicts.
MORAL INTENSITY AND ETHICAL ANALYSIS IN ACCOUNTING DECISION MAKING
Authors: Yusnaini Yusnaini , Meirawati Eka
Published: March 2023

Theoretically there are four stages in ethical decision making, namely identification of an ethical dilemma, ethical judgment, ethical intention, and ethical action. This study examines the relationship between perceived moral intensity and the first three stages of the ethical decision-making process for accounting students. This study uses an experimental design that uses four business scenarios. This study examines three stages in the ethical decision-making process and provides additional support for the role of moral intensity in ethical decision-making. The results of empirical testing at least partially support all the hypotheses developed in this study. Ethical identification was significantly related to ethical judgment and ethical intention of the four scenarios and ethical judgment was significantly related to ethical intention of the four scenarios. The two dimensions of moral intensity are differently related to the stages of the ethical decision-making process with social consensus emerging as the most important component of moral intensity
Educación jurídica e innovación tecnológica: un ensayo crítico
Authors: Bonilla Maldonado Daniel
Published: March 2023

The article is divided into three parts. In the first part, I describe three of the most frequent answers to the question, why is it necessary, important, or urgent for technological innovation to be incorpo- rated into law schools? The first two answers are directly related to agents of the market that demand legal education: law students and law firms. On the one hand, the legal literature that deals with this issue argues that law schools must innovate in technological matters to meet the expectations and needs of the new generations of law students. On the other hand, the literature argues that this aim should be achieved to satisfy the expectations and needs of law firms, that are the ones that hire new law school graduates. The third response indicates that technological innovation in law schools is necessary because it allows students to achieve learning objectives more effectively. In the second part, I offer a critique of the first two answers, those that react to, and want to meet, the needs both of the legal services market and the educational services market. This critique is based on a Heideggerian interpretation of technology. In the third part, I present my criticism of the third answer, which closely connects the pedagogical aims of legal education and technological innova- tion. In this section I argue that the third answer (i) is weakened by the naturalistic fallacy; (ii) does not empirically support its conclusions, or at least does not support them sufficiently, and presents some of its empirical arguments as absolute, although there is no consensus in the legal, scientific, or pedagogical communities around them; (iii) does not offer specific and detailed arguments that show how technological innovation may allow us to fulfill the objectives that legal education usu- ally pursues; and (iv) it obscures the connection between technology and power in legal education.
Wild Exaggeration and Vast Potential: Technology’s Limits and Promise in Legal Education
Authors: Crawford Colin
Published: March 2023

The purpose of this article is to assess the extent of technology’s benefits for legal education. The ar- gument makes two main claims. First, it argues that an understanding of the neuroscience of learning may focus and ground legal and other educators on the possible benefits and roles of technology in education. Second, it argues that, once this is done, technology can be applied to democratize access to legal education. The article concludes, however, by pointing out areas of risk and concern regarding this project.
GÜNDELİK HAYAT VE GÜNDELİK HAYATIN SOSYOLOJİSİ: BİR LİTERATÜR ÇALIŞMASI
Authors: YILMAZ ALTUN Öznur
Published: March 2023

Gündelik, sıradan olanın rutin akışı içinde, sosyal yapının ve aktörün doğrudan etkileşimi ve ilişkisi içinde yeniden ve yeniden üretilir. Bir etkileşim alanı olarak gündelik hayat, diyalektik bir sürece işaret eder: Sosyal gerçeği yaratan ve sosyal gerçeklik tarafından yaratı-lan. Failin kim olduğu ve yapı ile ilişkinin neliği üzerine yoğun tartışma, bu diyalektik süreci anlamanın araçlarından biridir. Gündelik hayat, muğlak, sınırları net olmayan bir olgudur. Gündelik hayatın bu muğlaklığı, heterojen bir yapısı olmasından kaynaklanır. Homojen olmayan bu etkileşim alanı, çoğullukların izlenmesine kapı aralar. Faillerin ben-liklerini ortaya koymasına zemin oluşturur. Bu açıdan gündelik hayat ve gündelik hayatın sosyolojisi, toplumsal ilişkilerin görünürlüğünde önemli bir kaynak haline gelir. Çalışma-da yanıt aranan sorulardan birkaçı şöyle sıralanabilir: Gündelik nedir? Gündelik hayatın sınırları nelerdir? Gündelik hayatın sosyolojisi muğlaklığına rağmen mümkün müdür? Bu sorulara yanıt ararken Fransız sosyolojisinin gündelik hayat sosyolojisindeki öncü isimle-rinden Henri Lefebvre, Michel de Certeau ve Agnes Heller’in kavrama yaklaşımları değer-lendirilmiştir. Bu yaklaşımlardan hareketle gündelik hayat tanımlanmış ve gündelik hayatın sosyolojisinde öne çıkan kavramlar incelenmiştir.
Management of pain in children with cancer admitted to the pediatric department of university hospital center
Authors: Bachir NABTI  , Meriem Yasmine KELLOU  , Amir YAHIA SAAD  , Nadia LADJOUZI
Published: March 2023

Pain management in pediatric cancer patients is a significant concern among caregivers, as it is the most prevalent symptom and often undertreated. This study conducted a review of the literature on pain management protocols for hospitalized cancer children, and also conducted a case report on pain management practices at a Central Hospital Pharmacy and Pediatric Oncology Ward. The study found that the majority of patients admitted to the pediatric oncology ward were diagnosed with lymphocytic leukemia, and that pain in children with cancer was not only caused by the cancer itself, but also by medical procedures such as myelograms and venipunctures. Abdominal pain and lower limb pain were the most common pain locations reported. The study revealed that pain management was not optimal, with only pharmacological tools being used and a limited number of antalgic and analgesic medications being available due to drug shortages. The majority of patients (65%) still experienced pain even after receiving pain medication, indicating a need for improved pain management protocols in pediatric oncology.
The application of Pennes’ bioheat equation to determine the effect of temperature on drug diffusion
Authors: Kubugha Wilcox Bunonyo  , Paul Ziakede Awomi
Published: March 2023

In this work, we discuss how temperature (internal heat) affects medication distribution between the stomach and circulatory compartments. The study shows that the behavior of medication distribution is related to high or low temperatures in the compartments under examination (the stomach and bloodstream). Here, we attempted to comprehend the behavior of a medicine supplied to the body over time by solving the models set up to mimic the system. The model (a system of ODEs) was solved both analytically and computationally using Wolfram Mathematica. The results reveal that as the temperature increases, the medication delivered into the system diffuses quicker between the compartments, and as the temperature decreases, the medication diffuses slower, demonstrating the peculiarity of this study effort.
ACADEMIC RESILIENCE AND STUDENTS ENGAGEMENT IN HIGHER EDUCATION: STUDY ON POST-PANDEMIC BEHAVIOUR
Authors: Sartika Sri Hardianti , Nirbita Betanika Nila
Published: March 2023

The impact of the Covid-19 pandemic on the education sector is the closure of educational institutions globally and the change in learning methods to online learning. However, the government is currently re-implementing face-to-face learning to avoid learning in education. This transition phenomenon poses a challenge not only for lecturers but also for students, especially students who have been accustomed to doing online learning since they started college. Academic resilience and student engagement are two aspects that students need to adapt to learning during the transition from online learning to face-to-face learning. The focus of this research is to examine academic resilience and students' engagement in higher education during the transition period of existing learning methods. The research method used is descriptive quantitative, with 376 participants (23% male, 77% female) starting college in 2019-2022. The research instrument was adopted from the Academic Resilience Scale (ARS-30) and the Student Engagement Scale from Gunuc. The analysis results of academic resilience on perseverance, reflecting and adaptive help-seeking, and negative affect and emotional response in higher education on post-pandemic behavior at high criteria (78,70%). The analysis results of student engagement on emotional engagement, cognitive engagement, and campus engagement in higher education on post-pandemic behavior at high criteria (80,3%).
DEVLETİN KÖKENİNE YÖNELİK İRADE VE OLGU KURAMLARINA DAİR DEĞERLENDİRMELER
Authors: ÖZER Mehmet Akif , KARTAL Meryem
Published: March 2023

Devletin ortaya çıkışı, kökeni, toplumdaki işlevi, toplum için ifade ettiği anlam gibi konular yüzyıllardan beri sosyal bilimcilerin tartışma konusu olmuştur. Siyasi bir birlik olan devlet hakkındaki tartışmalarda, farklı disiplinler, devlete farklı bakış açılarıyla yaklaşmış ve tam bir fikir birliği sağlanmamıştır. Bilindiği gibi devlet olgusu insanlık ile yaşıt kabul edilmektedir. Bu nedenle siyasal bilimciler ve pek çok düşünür asırlar boyunca devletin kökeninin ne olduğunu sorgulamışlardır. Bu süreçte devletin ne olduğuna yönelik bir görüş birliğinin oluşmamasının temel nedeni devletin mahiyetine göre düşünce farklılığından kaynaklanmaktadır. Literatürde devletin kökenine yönelik geliştirilen kuramlar, sosyal bilimlerdeki teorisyenler tarafından birbirinden farklı ve oldukça çeşitli unsurlar dikkate alınarak sınıflandırılmıştır. Devletin kökeninin açıklanması aynı zamanda devletin tanımlanması, görev, sorumluluk ve amacının belirlenmesi ile oldukça yakından ilişkilidir. Bu kapsamda çalışmanın amacı, irade ve olgu kuramları kapsamında John Locke ve Karl Marx’ın devlet anlayışını, eşitlik, özgürlük ve mülkiyet kavramları üzerinden değerlendirmektir. Çalışmanın kapsamı gereği literatürde yer alan tüm kuramlar açıklanmayıp, yalnızca toplumsal sözleşme kuramında Locke’un, doğal olgu kuramları kapsamında da Marx’ın görüşlerine yer verilecektir.
Методичний підхід до визначення найбільш доцільних напрямків розвитку космічних систем в умовах обмеженого ресурсу
Authors: Воробйов О. В. , Дзеверін І. Г. , Беспалько О. В. , Козлова О. В.
Published: March 2023

Пропонується методичний підхід до визначення найбільш доцільних напрямків розвитку космічних систем в умовах обмеженого ресурсу. Визначені проблеми і протиріччя щодо розвитку космічної діяльності в Україні, сутність яких полягає в обмеженості ресурсів як наслідок агресії Російської Федерації проти України, недостатньому рівні готовності технологій до швидкого виробництва зразків космічної техніки від моменту їх розробки та впливу на процес прийняття рішення щодо визначення доцільних напрямків розвитку космічних систем множини факторів політичного, економічного та технологічного характеру, які формують нестохастично невизначене середовище. Окреслено програму подальших досліджень щодо розв’язання зазначених проблем та протиріч.
Numerical and experimental investigation of rocking stability of rigid blocks during single sine-wave excitation
Authors: Čeh Nina , Jelenić Gordan
Published: March 2023

Rocking stability of a rigid prismatic block standing on a rigid base subject to a simple harmonic acceleration function is still an important dynamics problem, in which energy loss is often not treated accurately enough. The energy loss at impacts during rocking is here examined. The stability for various slendernesses and sizes of a rocking block is assessed numerically, where an improved coefficient capable of estimating the size effect is considered. A number of relevant cases are validated experimentally, with a specially designed set of well-controlled and documented rocking benchmark tests on a shaking table system.
Effects of Housing Density on Reproductive Performance, Intracage Ammonia, and Welfare of Mice Continuously Housed as Breeders in Standard Mouse and Rat Caging
Authors: Cho Ellen , Walsh Courtney A , D'Angelo-Gavrish Nicole M , Wilson Steven R , Cirillo Patricia A , Smith Peter C
Published: March 2023

Maintaining compliance with cage density recommendations inThe Guide for the Care and Use of Laboratory Animalsprecludes continuous trio breeding in standard-sized mouse cages. This study evaluated and compared several parameters of reproductive performance, intracage ammonia concentration, and fecal corticosterone levels in 2 strains of mice, C57BL/6J (B6) and B6.129S(Cg)-Stat1tm1Dlv/J (STAT1–/–), housed as continuous breeding pairs or trios in standard-sized mouse cages, and continuous breeding trios in standard-sized rat cages. Reproductive performance data indicated that STAT1–/–trios raised in rat cages weaned significantly more pups per litter than did STAT1–/–trios raised in mouse cages, and B6 mice had higher pup survival rates at weaning than did STAT1–/–mice in mouse cages housing continuous breeding trios. In addition, the Production Index was significantly higher for B6 breeding trios in rat cages than for B6 trios in mouse cages. Intracage ammonia concentration increased with cage density, with significantly higher ammonia concentrations in mouse cages housing trios compared with rat cages housing trios. However, fecal corticosterone levels did not differ significantly regardless of genotype, breeding configuration, or cage size, and daily health checks revealed no clinical abnormalities under any of the conditions evaluated. These results suggest that, although continuous trio breeding in standard-sized mouse cages does not seem to compromise mouse welfare, it offers no advantage in reproductive performance compared with pair breeding, and in some cases, it might be disadvantageous in this regard. Further, high intracage ammonia in mouse cages containing breeding trios might necessitate more frequent cage changes.
La lectura como un eje de vínculo y acogida: transformaciones de los participantes de una Comunidad de lectura de literatura en un entorno rural
Authors: Bolívar-Castañeda Alejandra
Published: March 2023

La literatura posibilita el encuentro, el cual favorece la profundización en las comprensiones e interpretaciones tanto sobre lo literario como la vida misma, constituyéndose como una invitación para construir nuevos sentidos y significados. Con el objetivo de comprender las transformaciones de los participantes de una Comunidad de lectura (un espacio-tiempo de contemplación y diálogo colectivo sobre la literatura), se analiza, a partir de la teoría fundamentada, la información recolectada en audios, videos, fotografías, producciones de los participantes y bitácoras durante las 11 sesiones de su consolidación en un contexto rural. Se identifica, así, la potencialidad de la literatura para acompañar los retos que implica el encuentro con otros. De este modo, se plantea como un eje a partir del cual tejer complicidades y prácticas de acogida que favorezcan la construcción de actitudes e identidades que reconozcan a los otros como interlocutores en la construcción de distintos mundos posibles.
Voces e identidades líquidas en el discurso de las nuevas masculinidades en el mundo hispánico
Authors: Aparicio Yannelys , González García Juana María
Published: March 2023

Este número especial aborda voces femeninas y masculinas que, desde la literatura reciente en lengua española, exploran nuevas formas de identidad y expresión, discursos transgresores que pretenden desestabilizar los estereotipos de género tradicionalmente asentados.
Mediating Role of Brand Image in the Relationship between Corporate Social Responsibility and Brand Equity: An Investigation of Unilever Bangladesh Limited
Authors:   East Delta University, Al Karim Rashed , Fayez Mohammed Arman ,   East Delta University
Published: March 2023

Corporate Social Responsibility (CSR), is one of the most discussed topics when it comes to operationalising a unique approach to do marketing and as such,create a competitive advantage for the company. Despite its popularity,CSR isnot properly addressed by many Bangladeshi companies. This study sheds light upon the concept of CSR in the perspective of a multinational company, Unilever Bangladesh Limited, which has been active with their CSR initiatives for years now. This research explains the concept of CSR and discusses the dimensions of CSR (economic, social and environmental) and their benefits through the TBL paradigm. Literature has been added based on previous researches defining brand image and brand equity and addressing the relationships between CSR dimensions and brand image and brand equity. Hypotheses were then proposed to reach the research objectives of this study. Data were collected from 124 respondents through conveniencesampling technique. An online-based survey was conducted due to lockdownorder due toCovid-19 outbreak. The outcomes of this study confirm a significant and positive mediating effect of brand image between the relationships of economic CSR and the socialCSR activities with brand equity, while the mediating effect of brand image doesnot exist in between the relationship of environmental CSR activities and brand equity.Finally, findings of the study may help to create a positive mindset of customers regarding the good intents of Unilever Bangladesh Limited towards Sustainable Living Plan.
Appraising Trends in Residential Property Investment Returns Relative to Infrastructure Conditions in Ilorin, Nigeria
Authors:   University of Ilorin, Sunday Adeogun Adekunle , Iyanda Sule Abass ,   Federal University of Technology Minna, Ganiyu Amuda-Yusuf ,   University of Ilorin
Published: March 2023

Infrastructure serves as an indicator to make real estate investment flourish, build the platform for the real estate investment market to thrive, and also to boost returns on property investment. Despite availability of some infrastructure,the property investment market still plagued with less expected returns as a result of non-functionality of neighborhood infrastructure. The study focused on the appraisal of the trends in residential property investment returns between year 2009 to 2018, relative to infrastructure condition in the study area. Data were obtained from practising real estate firms and residents of selected neighborhoods using a structured questionnaire. The study adopted simple random sampling technique. Out of 2,228 questionnaires administered in the selected neighborhoods, in Ilorin, 664 were returned and valid for the analysis. Descriptive mean method of data analysis was employed, coefficient of variation and spearman’s rank-order correlation model was adopted to comparethe property investment return in the selected areas of Ilorin and to determine the infrastructure indexwith benchmark for the minimum acceptable standard condition. Also, Kendall coefficient of concordance was also used to test the relationship among the ranked factors. The result shows that Sabo-Oke and Fate property market of Ilorin performed better than Adewole Housing Estate and GRA (Government Reservation Area) based onrisk-return ratio analysis, of which Sabo-Oke and Fate revealed the most consistent property market returns while GRA and Adewole Housing Estate residential market showed high level market volatility due to risky nature of the market. Sabo-Oke and Fate markets showed a stable market at minimum risk ranges between 8%-36%. The infrastructure condition indices in GRA and Adewole Housing Estate is higher than ideal condition index (Benchmark), ranges between 82%-92% and 81%-94% when compared with the average international standard at 60%, while infrastructure conditions in Sabo-Oke and Fate found a bit below the average international standard condition. The study also found that the performance of residential property investment is magnificent in the area where there is a frequent market transaction with good and functional infrastructure, as it is discovered across the selected neighborhoods in Ilorin. The study concluded that infrastructure have weighty influence on residential property investment returns relative to functional infrastructure and that, residential property market performance hinges on functional infrastructure and it must be given extreme consideration when making a property investment decision.
LEARNING A FOREIGN LANGUAGE BY READING BOOKS
Authors: Maslo Iryna
Published: March 2023

The article is about foreign language learning. It is an ongoing process, during which you need to practice listening, reading and processing information. Reading is one of the main tools in learning. By analyzing a written word or sentence structure over
La visita de los mil disfraces: El diario del año de la peste (1722), de Daniel Defoe
Authors: Castro Santana Anaclara
Published: March 2023

El artículo contiene una nota crítica sobre El diario del año de la peste (1722), de Daniel Defoe, una novela de corte histórico que narra el progreso de la peste negra que devastó Londres en 1665. Se hace una invitación a leer esta obra (que el 17 de marzo de 2022 cumplió trescientos años de haberse publicado), y se observan algunos puntos de interés tanto de su autor como de la trama de la novela y algunas implicaciones de asociar el sustantivo visita con el advenimiento de la peste. El artículo se vincula con la experiencia de la humanidad del siglo XXI ante la pandemia covid-19.
RANCANG BANGUN SISTEM INFORMASI E-DOCUMENT KEPENDUDUKAN PADA DESA PASIR JAYA
Authors: Septarini Ri Sabti , Sugiyani Yani , Aksani Muhammad Luthfi , Nuramalia Eva
Published: March 2023

Kantor Desa Pasir Jaya merupakan salah satu instansi pemerintah yang masih menggunakan sistem manual dalam proses pengarsipan datanya, terutama dalam data kependudukan. Oleh karena itu, diperlukan sistem yang lebih terkomputerisasi untuk membantu petugas dalam pengarsipan. Dalam penelitian ini, penulis menggunakan metode URS dalam analisisnya, metode scrum dalam pengembangan sistem dan metode black box dalam pengujiannya. Sistem informasi e-Document pada Desa Pasir Jaya yang dihasilkan dengan menggunakan metode Scrum secara nyata dapat memenuhi kebutuhan pengguna sesuai dengan product backlog yang dapat dilihat dari fiturnya.
Comparison of Physiotherapy Education on Course Basis in terms of Student Satisfaction During the Covid-19 Pandemic Period: Online, Hybrid, and On-Campus Education
Authors: YAZICI MUTLU Çiğdem , PEKDAŞ Mehmet Alperen , ÇİL Elif Tuğçe , ARSLAN Deniz , BELCASTRO ERGEN Kristen , CAN Sahra Şirvan
Published: March 2023

In the study, aimed to compare three different education periods, On-Campus Education (2019), Hybrid Education (2020), and Online Education (2021), in terms of students' satisfaction within the scope of the courses offered in Physiotherapy and Rehabilitation program. The dataset of study collected as a retrospective study from the Physiotherapy and Rehabilitation Department in Health Sciences Faculty of Yeditepe University, Istanbul. The spring semester students of 2019, 2020, and 2021 (respectively, n=170; n=158; n=229) participated in the study. The assessment of students’ learning outcomes was obtained from questionnaires prepared by the research team. Answers are allowed upon a 6-point Likert scale (0:Strongly Disagree - 5:Strongly Agree). According to the Analysis of Variance (ANOVA) test results, in the Introduction to Physiotherapy Occupation, Hydrotherapy, Manipulative Therapy-II Functional Anatomy and Kinesiology-II, Neurologic Rehabilitation, Orthosis and Prosthesis Rehabilitation and Physiotherapy in Sport courses, statistically significant difference was found (respectively, p=0.005, p=0.001 p=0.009, p=0.001, p=0.018, p=0.001, p=0.001). According to the satisfaction of the Physiotherapy students at three-grade levels, the courses with high theoretical content may be given online. Therefore, the online system can be integrated into the physiotherapy education system, but it cannot replace campus education in practical courses.
Amyloid Formation of Stefin B Protein Studied by Infrared Spectroscopy
Authors: Novak Urban , Žerovnik Eva , Taler-Verčič Ajda , Žnidarič MagdaTušek , Zupančič Barbara , Grdadolnik Jože
Published: March 2023

Background: Stefin B, an established model protein for studying the stability and mechanism of protein folding, was used for monitoring protein aggregation and formation of amyloid structure by infrared spectroscopy. Methods: The analyses of the integral intensities of the low frequency part of the Amide I band, which is directly connected to the appearance of the cross-β structure reveals the temperature but not pH dependence of stefin B structure. Results: We show that pH value has significant role in the monomer stability of stefin B. Protein is less stable in acidic environment and becomes more stable in neutral or basic conditions. While in the case of the Amide I band area analysis we apply only spectral regions characteristic for only part of the protein in cross-β structure, the temperature study using multivariate curve resolution (MCR) analysis contains also information about the protein conformation states which do not correspond to native protein nor protein in cross-β structure. Conclusions: These facts results in the slightly different shapes of fitted sigmoid functions fitted to the weighted amount of the second basic spectrum (sc2), which is the closed approximation of the protein spectra with cross-β structure. Nevertheless, the applied method detects the initial change of the protein structure. Upon the analysis of infrared data a model for stefin B aggregation is proposed.