bluuebunny/crossref_metadata_2025 huggingface dataset:
Preference, Perception, and Acceptability of Fluid Gels as a Potential Age-Appropriate Dosage Form for Elderly Patients with Dysphagia
Authors: Aziz Zul Hadif Abd , Katas Haliza , Omar Marhanis Salihah , Mohamed Shah Noraida , Mohamad Yusop Salma , Shafiee Mohamad Nasir , Mohd Tarmizi Siti Fatimah
Published: April 2022

The development of pharmaceutical dosage forms that are tailored to specific populations according to their preferences and acceptability could improve medication adherence, which could lead to effective pharmacotherapy. This study evaluated the preference for and perceptions of fluid gels as a potential age-appropriate dosage form for older adults with dysphagia. The palatability and swallowability of the developed fluid gels were also assessed to determine the consumer acceptability of this formulation. A cross-sectional survey was conducted through the electronic distribution of a self-administered questionnaire among adults in Malaysia between April and December 2021. A randomized and double-blinded clinical study was conducted to evaluate the palatability and swallowability of the fluid gels in 30 healthy participants. A cross-sectional study involving 673 respondents revealed that the fluid gels were perceived positively by consumers (64.4%), were easily swallowed (50.8%), were safe to be consumed (45.3%), and were suitable as a new pharmaceutical formulation (43.8%). The clinical study shows that moderately thickened fluid gels masked the bitterness of the medication and were easily swallowed. The newly developed fluid gels were also positively perceived by the participants. Taken together, fluid gels have shown great potential as an innovative oral formulation that is suitable for consumption by elderly patients with dysphagia.
Phytosterol-Loaded Surface-Tailored Bioactive-Polymer Nanoparticles for Cancer Treatment: Optimization, In Vitro Cell Viability, Antioxidant Activity, and Stability Studies
Authors: Karim Shahid , Akhter Md Habban , Burzangi Abdulhadi S. , Alkreathy Huda , Alharthy Basma , Kotta Sabna , Md Shadab , Rashid Md Abdur , Afzal Obaid , Altamimi Abdulmalik S. A. , Khalilullah Habibullah
Published: April 2022

This study aimsto optimize, characterize, and assess the phytosterol-loaded surface-tailored bioactive Alginate/Chitosan NPs for antitumor efficacy against breast cancer. β-Sitosterol-loaded Alginate/Chitosan nanoparticles (β-SIT-Alg/Ch-NPs) were fabricated using an ion-gelation technique, and then the NPs’ surfaces were activated using an EDC/sulfo-NHS conjugation reaction. The activated chitosan NPs werefunctionalized with folic acid (FA), leveled as β-SIT-Alg/Ch-NPs-FA. Moreover, the functionalized NPs were characterized for size distribution, polydispersity index (PDI), and surface charge, FT-IR and DSC. β-SIT released from β-SIT-Alg/Ch-NPs was estimated in various biorelevant media of pH 7.4, 6.5, and 5.5, and data werefitted into various kinetic models. The cytotoxic study of β-SIT-Alg/Ch-NPs-FA against the cancer cell line was established. The antioxidant study of developed β-SIT-Alg/Ch-NPs was performed using DPPH assay. The stability of developed optimized formulation was assessed in phosphate buffer saline (PBS, pH 7.4), as per ICH guidelines. The drug-entrapped Alg/Ch-NPs-FA appeared uniform and nonaggregated, and the nanoscale particle measured a mean size of 126 ± 8.70 nm. The %drug encapsulation efficiency and %drug loading in β-SIT-Alg/Ch-NPs-FA were 91.06 ± 2.6% and 6.0 ± 0.52%, respectively. The surface charge on β-SIT-Alg/Ch-NPs-FA was measured as +25 mV. The maximum β-SIT release from β-SIT-Alg/Ch-NPs-FA was 71.50 ± 6.5% in pH 5.5. The cytotoxic assay expressed an extremely significant antitumor effect by β-SIT-Alg/Ch-NPs-FA when compared to β-SIT-suspension (p < 0.001). The antioxidant capacity of β-SIT-Alg/Ch-NPs-FA was 91 ± 5.99% compared to 29 ± 8.02% for β-SIT-suspension. The stability of NPs noticed an unworthy alteration (p > 0.05) in particle sizes and other parameters under study in the specific period.
Circulating miRNAs Are Associated with Inflammation Biomarkers in Children with Overweight and Obesity: Results of the I.Family Study
Authors: Lauria Fabio , Iacomino Giuseppe , Russo Paola , Venezia Antonella , Marena Pasquale , Ahrens Wolfgang , De Henauw Stefaan , Eiben Gabriele , Foraita Ronja , Hebestreit Antje , Kourides Yiannis , Molnár Dénes , Moreno Luis , Veidebaum Toomas , Siani Alfonso
Published: April 2022

Increasing data suggest that overnutrition-induced obesity may trigger an inflammatory process in adipose tissue and upturn in the innate immune system. Numerous players have been involved in governing the inflammatory response, including epigenetics. Among epigenetic players, miRNAs are emerging as crucial regulators of immune cell development, immune responses, autoimmunity, and inflammation. In this study, we aimed at identifying the involvement of candidate miRNAs in relation to inflammation-associated biomarkers in a subsample of European children with overweight and obesity participating in the I.Family study. The study sample included individuals with increased adiposity since this condition contributes to the early occurrence of chronic low-grade inflammation. We focused on the acute-phase reagent C-reactive protein (CRP) as the primary outcome and selected cytokines as plausible biomarkers of inflammation. We found that chronic low-grade CRP elevation shows a highly significant association with miR-26b-3p and hsa-miR-576-5p in boys. Furthermore, the association of CRP with hsa-miR-10b-5p and hsa-miR-31-5p is highly significant in girls. We also observed major sex-related associations of candidate miRNAs with selected cytokines. Except for IL-6, a significant association of hsa-miR-26b-3p and hsa-miR-576-5p with TNF-α, IL1-Ra, IL-8, and IL-15 levels was found exclusively in boys. The findings of this exploratory study suggest sex differences in the association of circulating miRNAs with inflammatory response biomarkers, and indicate a possible role of miRNAs among the candidate epigenetic mechanisms related to the process of low-grade inflammation in childhood obesity.
Multidecadal Land-Use Changes and Implications on Soil Protection in the Calore River Basin Landscape (Southern Italy)
Authors: Magliulo Paolo , Cusano Angelo , Sessa Sofia , Beatrice Marika , Russo Filippo
Published: April 2022

In Southern Italy, studies dealing with the analysis of multidecadal land-use changes at the basin scale are scarce. This is an important gap, considering the deep interrelationships between land-use changes, soil erosion, and river dynamics, and hazards at the basin scale and the proneness of Southern Italy to desertification. This study provides a contribution in filling this gap by analyzing the land-use changes occurring in an inner area of Southern Italy, i.e., the Calore River basin, between 1960 and 2018. Working to this aim, we conducted a GIS-aided comparison and analysis of three land-use maps of the study area from 1960, 1990, and 2018, respectively. We analyzed land-use changes at the basin, physiographic unit, and land-use class scale. We also interpreted the results in terms of variations in soil protection against erosion. Most of the detected land-use changes occurred between 1960 and 1990 and mainly consisted of the afforestation of agricultural lands. The latter was mainly concentrated in the alluvial plains and, to a lesser extent, on mountainous reliefs. In contrast, between 1990 and 2018, the land-use remained unchanged in more than 90% of the studied landscape. Artificial surfaces increased by about six times over a period of ~60 years; notwithstanding, they currently occupy about 4% of the basin area. The detected changes led to an overall increase in soil protection against erosion at the basin scale.
Mantle Xenoliths from Huanul Volcano (Central-West Argentina): A Poorly Depleted Mantle Source under Southern Payenia
Authors: Bertotto Gustavo W. , Mazzucchelli Maurizio , Giovanardi Tommaso , Conceiçao Rommulo V. , Zanetti Alberto , Schilling Manuel E. , Bernardi Mauro I. , Ponce Alexis D. , Jalowitzki Tiago , Gervasoni Fernanda , Cipriani Anna
Published: April 2022

Huanul is a shield volcano with several lava flows hosting mantle xenoliths erupted during the Pleistocene (0.84 ± 0.05 Ma). It is located in the southern part of the Payenia Volcanic Province, which is among the largest Neogene-Quaternary volcanic provinces of South America. The volcanism here has been ascribed as the northernmost expression of the back-arc volcanism of the Andean Southern Volcanic Zone. We present the first petrographic and mineral chemistry study of mantle xenoliths collected from Huanul lavas with the aim of reconstructing directly the mantle source of the Payenia Volcanic Province. Xenoliths are commonly small (<5 cm in radius) but scarcely crossed by basaltic veins. All xenoliths have a fertile lherzolitic modal composition and are equilibrated in the spinel-facies. Most of them exhibit an almost primitive-mantle geochemical affinity, characterized by slightly depleted clinopyroxene REE patterns reproducible by partial melting degrees between 0 and 4% of a PM source. Geothermobarometric P-T estimates of clinopyroxene-orthopyroxene couples form a linear trend between 10 and 24 kbar with constant increase of T from 814 to 1170 °C along a 50–60 mW/m2 geotherm. Evidences of interaction with the host basalts occur as spongy textures in clinopyroxene and reacted spinel, which tend to became more restitic in composition and show chromatographic or complete overprinting of the trace element compositions. The presence of plagioclase and calculated P-T values constrain this melt/rock reaction process between 6 and 14 kbar, during magma ascent, and fit the mantle adiabat model. Calculated melts in equilibrium with the primary clinopyroxenes do not fit the composition of the host basalt and, together with the geothermobarometric estimations, point to an asthenospheric mantle source for the magmatism in southern Payenia. The PM geochemical affinity of the xenoliths of Huanul is an extremely rare finding in the South America lithospheric mantle, which is commonly extensively refertilized by subduction-derived melts.
Evaluating the Existence of Vertebrate Deadfall Communities from the Early Jurassic Posidonienschiefer Formation
Authors: Maxwell Erin E. , Cooper Samuel L. A. , Mujal Eudald , Miedema Feiko , Serafini Giovanni , Schweigert Günter
Published: April 2022

Large vertebrate carcasses contain significant amounts of nutrients that upon death are transferred from the water column to the benthos, enriching the immediate environment. The organisms exploiting these ephemeral resources vary as the carcass decays, creating an ecological succession: mobile scavengers arrive first, followed by enrichment opportunists, sulfophilic taxa, and lastly reef species encrusting the exposed bones. Such communities have been postulated to subsist on the carcasses of Mesozoic marine vertebrates, but are rarely documented in the Jurassic. In particular, these communities are virtually unknown from the Early Jurassic, despite the occurrence of several productive fossil Lagerstätte that have produced thousands of vertebrate bones and skeletons. We review published occurrences and present new findings related to the development of deadfall communities in the Toarcian Posidonienschiefer Formation of southwestern Germany, focusing on the classic locality of Holzmaden. We report the presence of the mobile scavenger, enrichment opportunist, and reef stages, and found potential evidence for the poorly documented sulfophilic stage. Although rare in the Posidonienschiefer Formation, such communities do occur in association with exceptionally preserved vertebrate specimens, complementing a growing body of evidence that a temporarily oxygenated benthic environment does not preclude exceptional vertebrate fossil preservation.
The Association between Rapid Weight Loss and Body Composition in Elite Combat Sports Athletes
Authors: Baranauskas Marius , Kupčiūnaitė Ingrida , Stukas Rimantas
Published: April 2022

Rapid Weight Loss (RWL) is a rapid reduction in weight over a short period of time seeking to attain the norm required for a competition in a particular weight category. RWL has a negative health impact on athletes including the significant muscle damage induced by RWL. This study aimed to identify the association between RWL and body composition among competitive combat athletes (n = 43) in Lithuania. Our focus was laid on the disclosure of their RWL practice by using a previously standardized RWL Questionnaire. The body composition of the athletes was measured by means of the standing-posture 8-12-electrode multi-frequency bioelectrical impedance analysis (BIA) and the electrical signals of 5, 50, 250, 550 and 1000 kHz. This non-experimental cross-sectional study resulted in preliminary findings on the prevalence and profile of RWL among combat athletes in Lithuania. 88% of the athletes surveyed in our study had lost weight in order to compete, with the average weight loss of 4.6 ± 2% of the habitual body mass. The athletes started to resort to weight cycling as early as 9 years old, with a mean age of 12.8 ± 2.1 years. The combination of practiced weight loss techniques such as skipping meals (adjusted Odd Ratio (AOR) 6.3; 95% CI: 1.3–31.8), restricting fluids (AOR 5.5; 95% CI: 1.0–31.8), increased exercise (AOR 3.6; 95% CI: 1.0–12.5), training with rubber/plastic suits (AOR 3.2; 95% CI: 0.9–11.3) predicted the risk of RWL aggressiveness. RWL magnitude potentially played an important role in maintaining the loss of muscle mass in athletes during the preparatory training phase (β –0.01 kg, p < 0.001). Therefore, an adequate regulatory programme should be integrated into the training plans of high-performance combat sports athletes to keep not only the athletes but also their coaches responsible for a proper weight control.
African American Couples’ Experiences during an Exercise Intervention Interrupted by the COVID-19 Pandemic: A Qualitative Case Study
Authors: Hornbuckle Lyndsey M. , Cooke Wendy McLean , Rauer Amy , Barroso Cristina S.
Published: April 2022

Exercise intervention researchers often struggle to transition participants from supervised/laboratory-based exercise to independent exercise. Research to inform this critical juncture remains underdeveloped. This qualitative case study investigated the transition from laboratory-based to home-based training in a subset of middle-aged and older African American couples whose exercise intervention experience was interrupted by the COVID-19 pandemic. All four couples (N = 8) whose study participation was interrupted participated in dyadic interviews by videoconference. Two investigators independently reviewed verbatim transcripts, and then used an iterative open coding approach to identify themes from the qualitative data. Three main themes were identified: (1) resistance training program modifications, (2) partner interactions, and (3) external pandemic-related factors. Each theme included both positive and negative feedback related to participants’ experiences. Overall, virtual, home-based training appeared acceptable and feasible in this group. Further research is needed to investigate the utility of virtual training to effectively transition participants from laboratory-based to independent exercise.
Demographic Influences on Perceived Stressors of Construction Workers during the COVID-19 Pandemic
Authors: Liang Huakang , Yang Wenqian , Liu Tianhong , Xia Fan
Published: April 2022

Construction work is one of the most stressful occupations in the world, and the COVID-19 pandemic has only exacerbated this reality. This research conducted a detailed investigation on the perceived stressors of different demographic groups among construction workers. Empirical data were collected using a structured questionnaire in the Chinese construction industry. The empirical data were processed using both an independent sample t-test and an Analysis of Variance (ANOVA). The findings indicated that male workers reported greater workloads than did females. Married workers experienced more pandemic fear and job insecurity, and they were more sensitive to the poor working environment. Highly-educated workers were inclined to be more satisfied with organizational pandemic responses, and had lower job insecurity and role ambiguity, but they experienced heavier workloads. In addition, the differences in work experience and age were statistically significant with regards to job insecurity. This research contributes to the body of knowledge by giving a comprehensive understanding of demographic influences on perceived stressors among construction workers. It also provides valuable insights to identify sensitive demographic groups and promote their health and wellbeing during and after the pandemic.
Innovative Application of Chicken Eggshell Calcium to Improve the Functional Value of Gingerbread
Authors: Arnold Marcellus , Rajagukguk Yolanda Victoria , Sidor Andrzej , Kulczyński Bartosz , Brzozowska Anna , Suliburska Joanna , Wawrzyniak Natalia , Gramza-Michałowska Anna
Published: April 2022

Food waste, such as eggshell, can be an environmental problem if it is not properly managed. One of the ways to solve this is by using the eggshell as the cheap calcium source in food products. Polish gingerbread fortified with chicken eggshell powder (ESP) calcium was developed to solve the eggshell waste problem and to reduce the risk of osteoporosis. This study focused on the effect of ESP addition on basic composition, sensory evaluation, and antioxidative activity of gingerbread. Two samples of gingerbread without and with 3% (w/w of wheat flour) ESP, with controlled green tea powder (4% w/w of white chocolate) were analyzed. Results of the research showed that the addition of 3% ESP significantly increased the ash and calcium content (p < 0.05) without changing the appearance, aroma, texture, taste profiles, and the hedonic score of gingerbread. The gingerbread samples were then stored for 2 months and were analyzed every month. The hedonic evaluation of the aroma of both gingerbread samples decreased significantly (p < 0.05) during storage. During 2 months of storage, the antioxidative activity of gingerbread fortified with 3% ESP was not significantly different compared to the control (p > 0.05), particularly in ABTS and ORACFL assay. The ABTS, DPPH, and ORACFL assays showed decreasing antioxidative activity during storage, which was also in accordance with decreasing total phenolic content of both gingerbread samples. In PCL assay, the lipid-soluble antioxidant activity in gingerbread with 3% ESP was significantly higher during 2 months of storage, compared to the control (p < 0.05). The developed product might be a potential alternative to improve the calcium (26% daily value (DV) recommendation per 100 g) and antioxidant intake in order to prevent calcium deficiency. Gingerbread enriched with an organic source of calcium may become an innovative product to reduce the risk of developing osteoporosis in the elderly population, having potential health and economic significance, given the incidence of osteoporosis and the costs of treating this disease.
Walsh Family Resilience Questionnaire—Polish Adaptation (WFRQ-PL)
Authors: Nadrowska Natalia , Błażek Magdalena , Lewandowska-Walter Aleksandra , Błażek Wojciech , Zdun-Ryżewska Agata
Published: April 2022

Family resilience is a construct based on interactive processes occurring in the family, enabling the family to effectively overcome everyday stressors, as well as developmental and unpredictable crises. By observing how the family deals with difficulties using family resilience processes, we are able to support both parents and protect children against the harmful effects of unfavourable conditions. The aim of our research was to carry out the procedure of adaptation to the Polish language and culture of the Walsh Family Resilience Questionnaire. In this study, 930 Poles participated (72.5% women), aged from 18 to 63 (M = 26.94, SD = 9.8). They filled in the questionnaire online. Confirmatory factor analysis confirmed the model with three factors: belief system, organisational processes, and communication processes. The model indicators were found to be well suited to the data: χ2/df = 1.12, RMSEA = 0.01, CFI = 0.99, TLI = 0.99, SRMR = 0.04. The reliability (Cronbach’s alpha) of the scales was also satisfactory (0.94 for the belief systems, 0.86 for the organisational processes, and 0.94 for the communication processes). Tool validation with FRAS-PL scales showed convergence. We named the Polish version of the WFRQ Questionnaire Kwestionariusz Prężności Rodzinnej Walsh (WFRQ-PL) and found it to be a good tool for assessing the processes of family resilience in our country.
Sex-Specific Differences in Lower Body Fat Distribution and Association with Physical Performance among Healthy Community-Dwelling Older Adults: A Pilot Study
Authors: Kim Miji , Oh Jang-Hoon , Won Chang Won
Published: April 2022

This study aims to examine sex-specific differences in body composition and lower extremity fat distribution and their association with physical performance among healthy older adults. The pilot study comprises 40 subjects (20 men and 20 women) matched by age and body mass index. The participants undergo dual-energy X-ray absorptiometry, magnetic resonance imaging, and proton magnetic resonance spectroscopy (1H-MRS) to assess body composition and lower extremity fat distribution. 1H-MRS is used to measure the extramyocellular lipid (EMCL) and intramyocellular lipid (IMCL) contents of the lower leg muscles (soleus and tibialis anterior) at the maximum circumference of the calf after overnight fasting. The tibialis anterior IMCL, as assessed by 1H-MRS, is negatively associated with the five-times sit-to-stand test scores (rs = 0.518, p = 0.023) in men, while the soleus IMCL content is negatively associated with the timed up-and-go test scores (rs = 0.472, p = 0.048) in women. However, the soleus EMCL content is positively associated with the five-times sit-to-stand test scores (rs = −0.488, p = 0.040) in women, but this association is not statistically significant in men. This study shows an inverse correlation between IMCL content and physical performance in healthy older individuals and lower leg muscle-specific IMCL based on sex differences. Furthermore, our results suggest that greater EMCL content in the soleus and calf subcutaneous fat might affect physical performance positively in women but not men.
For Whom the Price Escalates: High Price and Uncertain Value of Cancer Drugs
Authors: Shin Gyeongseon , Kwon Hye-Young , Bae SeungJin
Published: April 2022

The price of cancer drugs has skyrocketed, yet it is not clear whether their value is commensurate with their price. More cancer drugs are approved under expedited review, which considers less rigorous clinical evidence, yet only 20% of them show an overall survival gain in the confirmatory trial. Moreover, clinical data are often generated based on small, single-arm studies with surrogate outcomes, challenging economic evaluation. With their high price and uncertain (marginal) clinical value, cancer drugs are frequently rejected by health technology assessment (HTA) bodies. Therefore, agencies, including the UK’s National Institute for Health and Care Excellence (NICE), have adopted cancer drug funds (CDF) or risk-sharing schemes to provide extra access for expensive cancer drugs which fail to meet NICE’s cost effectiveness threshold. With rising pricing and fewer new cancer medications with novel mechanisms of action, it is unclear if newly marketed cancer therapies address unmet clinical needs or whether we are paying too much. Transparency, equity, innovativeness, and sustainability are all harmed by a “special” approach for cancer medications. If early access is allowed, confirmatory trials within a certain time frame and economic evaluation should be conducted, and label changes or disinvestment should be carried out based on those evaluations.
Low Use of Long-Acting Reversible Contraceptives in Tanzania: Evidence from the Tanzania Demographic and Health Survey
Authors: Kikula Amani Idris , Moshiro Candida , Makoko Naku , Park Eunyoung , Pembe Andrea Barnabas
Published: April 2022

We aimed to determine the prevalence and factors associated with the use of long-acting reversible contraceptives (LARCs) among women of reproductive age in Tanzania. We analyzed the Tanzania Demographic and Health Survey (DHS) data from 2015 to 2016. The study included 8189 women aged 15–49 years. The relationship between various factors and LARC use was determined through various analyses. Among women with a partner/husband, 7.27% used LARCs, 21.07% were grand multiparous, and 20.56% did not desire more children. Women aged 36–49 years (adjusted odds ratio (AOR)-2.10, 95% confidence interval (CI): 1.11–3.96), who completed secondary education (AOR-1.64, 95% CI: 1.05–2.55), who did not desire more children (AOR-2.28, 95% CI: 1.53–3.41), with a partner with primary level education (AOR-2.02, 95% CI: 1.34–3.02), or living in richer households (AOR-1.60, 95% CI: 1.12–2.27) were more likely to use LARCs. Further, women with a partner who wanted more children were less likely to use LARCs (AOR-0.69, 95% CI: 0.54–0.90). Tanzania has a low LARC usage rate. Women’s age, wife and partner’s education status, couple’s desire for more children, and household wealth index influenced the use of LARCs, highlighting the need to reach more couples of lower socioeconomic status to improve LARC utilization.
Cohort Profile: The Korean Vietnam War Veterans’ Health Study Cohort (KOVECO)
Authors: Lee Wanhyung , Kim Ui-Jin , Ham Seunghon , Choi Won-Jun , Lee Seunghyun , Yoon Jin-Ha , Kang Seong-Kyu
Published: April 2022

During the Vietnam War, many troops and citizen were exposed to large amounts of Agent Orange (AO), and the hazardous effects of AO are continuously being researched and reported. The Korean Vietnam War Veterans’ Health Study Cohort (KOVECO) is a retrospective cohort to demonstrate the health status of the Korean Vietnam War veterans and their second-generation offsprings. The KOVECO is a collaboration of data from the Ministry of Patriots and Veterans Affairs and the National Health Insurance Sharing Service from 2002 to 2018. The study participants were all Korean Vietnam War veterans and their second-generation offsprings, and the references were the general population in which gender and region were matched with the participants. As of 2002, 191,272 Vietnam War veterans (1,000,320 comparisons) and 1,963,402 s-generations (1,173,061 references) were included in the cohort. The KOVECO consists of personal information, medical facility visit information, and general health examination information. The KOVECO could act as a health surveillance system, which would be able to detect long-term health effects caused by exposure to AO and provide a direction for policy making through academic research.
Intercomparison of Radon Flux Monitors at Low and at High Radium Content Areas under Field Conditions
Authors: Rábago Daniel , Quindós Luis , Vargas Arturo , Sainz Carlos , Radulescu Ileana , Ioan Mihail-Razvan , Cardellini Francesco , Capogni Marco , Rizzo Alessandro , Celaya Santiago , Fuente Ismael , Fuente Marta , Rodriguez Maria , Grossi Claudia
Published: April 2022

Interlaboratory exercises are a good tool to compare the response of different systems to the same quantity and to identify possible inconsistencies between them. One of the main goals of the EMPIR 19ENV01 traceRadon project is to harmonize radon flux measurements based on different systems and methodologies. In the framework of the traceRadon Project, two radon flux intercomparison campaigns were carried out in October 2021 at high and at low radon source areas. Four institutions participated in the field intercomparison exercises with their own systems. Every system was based on a specific radon monitor (diffusion or pump mode) and an accumulation chamber (with manual or automatic opening). Radon fluxes were calculated by each participant using both exponential and linear fittings of the radon activity concentration measured over time within the accumulation chambers. The results of this study show mainly: (i) the exponential approach is not advisable due to the variability of the radon flux and the leakage of the systems during long-time measurements; (ii) the linear approach should be applied to minimize the measurement period in agreement with the time response and sensitivity of the monitors; (iii) radon flux measured at high radon source areas (radium content of about 800 Bq kg−1) risks being underestimated because of the influence of advective effects; (iv) radon flux measured at low radon source areas (radium content of about 30 Bq kg−1) may present large uncertainties if sensitive radon monitors with pump mode are not used.
The Relationship between Different Large-Sided Games and Official Matches on Professional Football Players’ Locomotor Intensity
Authors: Caldeira Romualdo , Gouveia Élvio , Ihle Andreas , Marques Adilson , Clemente Filipe , Lopes Helder , Henriques Ricardo , Sarmento Hugo
Published: April 2022

Large-sided games (LSG) are commonly used in the training contexts for providing either technical/tactical or locomotor/physiological stimuli. Despite natural similarities with the official match, the locomotor profile seems to be different, which must be considered by the coaches to identify compensatory strategies for achieving the ideal dose of training. The aim of this study was two-fold: (1) to investigate the locomotor demands imposed by LSGs and the official matches; and (2) to compare the effect of different pitch sizes’ LSG conditions in the locomotor demands. This study followed an observational design. Sixteen professional football players from the same team (26.3 ± 3.0 years old) were included. The study was conducted over four weeks. The same GK + 10 × 10 + GK play format with different pitch sizes (i.e., area per player ranging between 195 m2 to 291 m2) was analyzed. Three official matches were also collected in which the 10 most demanding minutes were considered for further comparisons. Only the same players who participated in matches were considered in comparison with the LSG. The data were obtained using a 10-Hz global positioning system technology. Total distance (TD) and mechanical work (MW) scores increased 20% and 23%, respectively, between the smallest and biggest pitch sizes (p < 0.001). There was a significant difference in locomotor intensity metrics between opponents from different positions on the table (p = 0.001). The biggest LSG (i.e., 291 m2 per player) was the only one that required similar levels of locomotor intensity as required in the official full match. The present study demonstrates that LSG pitch size variation requires different locomotor intensities. Bigger pitch sizes cause an increase in TD and MW. In addition, considering the position on the table, the level of opponents induces different TD covered. Finally, the largest LSG simulates the official match more accurately.
Weekday and Weekend Differences in Eating Habits, Physical Activity and Screen Time Behavior among a Sample of Primary School Children: The “Seven Days for My Health” Project
Authors: Esposito Francesco , Sanmarchi Francesco , Marini Sofia , Masini Alice , Scrimaglia Susan , Adorno Emanuele , Soldà Giorgia , Arrichiello Fabrizio , Ferretti Filippo , Rangone Marilisa , Celenza Francesca , Guberti Emilia , Tiso Domenico , Toselli Stefania , Lorenzini Antonello , Dallolio Laura , Sacchetti Rossella
Published: April 2022

Background: Healthy eating and active lifestyle habits are essential for a child’s development, wellbeing, and health. School setting and family environment play a crucial role in shaping these habits and this could be reflected in different behavior patterns during weekdays and weekends. Methods: We investigated primary school children’s lifestyle habits through a cross-sectional analysis of 428 Italian primary school children, with a mean age of 8.99 years (±1.43). Data were collected from May to June 2017 using a weekly diary to assess children’s lifestyles. Results: Children who eat their morning snack and lunch at school three or more times during the weekdays were 5.47 times more likely (95% CI 3.02, 10.2) to consume adequate snacks and 7.79 times more likely (95% CI 4.43, 14.5) to have adequate meals than those who did not. Conclusion: Consumption of vegetables, lunch, and snacks are significantly more adequate during the weekdays as compared to the weekends. Physical activity levels did not differ between weekdays and weekends. Moreover, children spent more time engaged in physical activities than in front of a screen during both the weekdays and the weekends. The present results are good indicators of the importance of the school canteen in defining correct eating habits. Family-based and school-based interventions could represent valuable integrative strategies for promoting a healthy lifestyle in children.
Effect of Shift Work on Cognitive Function in Chinese Coal Mine Workers: A Resting-State fNIRS Study
Authors: Tian Fangyuan , Li Hongxia , Tian Shuicheng , Shao Jiang , Tian Chenning
Published: April 2022

Aim: Pilot study to examine the impact of shift work on cognitive function in Chinese coal mine workers. Background: Shift work is commonly used in modern industries such as the coal industry, and there is growing concern over the impact that shift work has on miners’ work performance and personal well-being. Method: A total of 54 miners working three shifts (17 in morning shift, 18 in afternoon, and 19 in night shift) participated in this exploratory study. A resting-state fNIRS functional connectivity method was conducted to assess the cognitive ability before and after the work shift. Results: Results showed significant differences in cognitive ability between before and after the work shifts among the three-shift workers. The brain functional connectivity was reduced ranking as the night, afternoon, and morning shifts. Decreased brain functional connectivity at the end of the working shift was found compared with before in the morning and afternoon shifts. Opposite results were obtained during the night shift. The resting-state functional brain networks in the prefrontal cortex of all groups exhibited small-world properties. Significant differences in betweenness centrality and nodal local efficiency were found in the prefrontal cortex in the morning and night shifts. Conclusions: The current findings provide new insights regarding the effect of shift work on the cognitive ability of Chinese coal mine workers from the view of brain science.
Improved Water and Waste Management Practices Reduce Diarrhea Risk in Children under Age Five in Rural Tanzania: A Community-Based, Cross-Sectional Analysis
Authors: McClelland Paul H. , Kenney Claire T. , Palacardo Federico , Roberts Nicholas L. S. , Luhende Nicholas , Chua Jason , Huang Jennifer , Patel Priyanka , Sanchez Leonardo Albertini , Kim Won J. , Kwon John , Christos Paul J. , Finkel Madelon L.
Published: April 2022

Diarrhea remains a significant cause of morbidity and mortality among children in developing countries. Water, sanitation, and hygiene practices (WASH) have demonstrated improved diarrhea-related outcomes but may have limited implementation in certain communities. This study analyzes the adoption and effect of WASH-based practices on diarrhea in children under age five in the rural Busiya chiefdom in northwestern Tanzania. In a cross-sectional analysis spanning July-September 2019, 779 households representing 1338 under-five children were surveyed. Among households, 250 (32.1%) reported at least one child with diarrhea over a two-week interval. Diarrhea prevalence in under-five children was 25.6%. In per-household and per-child analyses, the strongest protective factors against childhood diarrhea included dedicated drinking water storage (OR 0.25, 95% CI 0.18–0.36; p < 0.001), improved waste management (OR 0.37, 95% CI 0.27–0.51; p < 0.001), and separation of drinking water (OR 0.38, 95% CI 0.24–0.59; p < 0.001). Improved water sources were associated with decreased risk of childhood diarrhea in per-household analysis (OR 0.72, 95% CI 0.52–0.99, p = 0.04), but not per-child analysis (OR 0.83, 95% CI 0.65–1.05, p = 0.13). Diarrhea was widely treated (87.5%), mostly with antibiotics (44.0%) and oral rehydration solution (27.3%). Targeting water transportation, storage, and sanitation is key to reducing diarrhea in rural populations with limited water access.
Variability in Healthcare Expenditure According to the Stratification of Adjusted Morbidity Groups in the Canary Islands (Spain)
Authors: Company-Sancho Maria Consuelo , González-Chordá Víctor M. , Orts-Cortés María Isabel
Published: April 2022

Morbidity is the main item in the distribution of expenditure on healthcare services. The Adjusted Morbidity Group (AMG) measures comorbidity and complexity and classifies the patient into mutually exclusive clinical categories. The aim of this study is to analyse the variability of healthcare expenditure on users with similar scores classified by the AMG. Observational analytical and retrospective study. Population: 1,691,075 subjects, from Canary Islands (Spain), aged over 15 years with data from health cards, clinical history, Basic Minimum Specialised Healthcare Data Set, AMG, hospital agreements information system and Electronic Prescriptions. A descriptive, bivariant (ANOVA coefficient η2) and multivariant analysis was conducted. There is a correlation between the costs and the weight of AMG (rho = 0.678) and the prescribed active ingredients (rho = 0.689), which is smaller with age and does not exist with the other variables. As for the influence of the AMG morbidity group on the total costs of the patient, the coefficient η2 (0.09) obtains a median effect in terms of the variability of expenditure, hence there is intra- and inter-group variability in the cost. In a first model created with all the variables and the cost, an explanatory power of 36.43% (R2 = 0.3643) was obtained; a second model that uses solely active ingredients, AMG weight, being female and a pensioner obtained an explanatory power of 36.4%. There is room for improvement in terms of predicting the expenditure.
Genetic Variation in Rhipicephalus sanguineus s.l. Ticks across Arizona
Authors: Brophy Maureen , Riehle Michael A. , Mastrud Nikki , Ravenscraft Alison , Adamson Johnathan E. , Walker Kathleen R.
Published: April 2022

Rhipicephalus sanguineus s.l. (Latreille, 1806), the brown dog tick, is the most widely distributed tick species in the world. The two dominant lineages, a temperate group and a tropical group, are recognized as important disease vectors for both dogs and humans. The temperate and tropical lineages overlap in range in some regions of the world, including the southwestern United States, where recent outbreaks of Rocky Mountain spotted fever are linked to R. sanguineus s.l. While it is unclear to what extent they may differ in their capacity to transmit pathogens, finer-scale resolution of temperate and tropical lineage distribution may provide insight into the ecology of these two tick groups and the epidemiology of R. sanguineus s.l.-vectored diseases. Using diagnostic polymerase chain reaction assays, we examined the geospatial trends in R. sanguineus s.l. lineages throughout Arizona. We found the temperate and tropical lineages were well delineated, with some overlap in the eastern part of the state. In one county, tropical and temperate ticks were collected on the same dog host, demonstrating that the two lineages are living in sympatry in some instances and may co-feed on the same host.
Home-Based High-Intensity Interval Exercise Improves the Postprandial Glucose Response in Young Adults with Postprandial Hyperglycemia
Authors: Nakayama Yuto , Ono Kumiko , Okagawa Junya , Urabe Junji , Yamau Ryoga , Ishikawa Akira
Published: April 2022

Postprandial hyperglycemia can be corrected by exercise; however, the effect of home-based high-intensity interval exercise (HIIE), a new time-efficient exercise, on glycemic control is unclear. This study aimed to investigate the effect of home-based HIIE on postprandial hyperglycemia. Twelve young adult males (mean age: 24.3 ± 2.3 y) with postprandial hyperglycemia that had not yet led to diabetes completed home-based HIIE, moderate-intensity continuous exercise (MICE), and control conditions on separate days, randomly. The intervention began 30 min after the start of a standardized meal intake, with 11 min of HIIE completed at maximal effort in the home-based HIIE condition, 30 min of running performed at 50% maximum oxygen uptake in the MICE condition, or 30 min of sitting at rest completed in the control condition. The participants sat at rest after each intervention for up to 120 min. Interstitial fluid glucose concentrations were measured using a continuous glucose monitoring system that scanned every 15 min for up to 2 h after the meal. The glucose concentrations after the meal were significantly lower in the home-based HIIE and MICE conditions than in the control condition (p < 0.001). There were no significant differences in the glucose concentrations between the home-based HIIE and MICE conditions. In conclusion, home-based HIIE was able to correct postprandial hyperglycemia.
Role of Environmental Quality of Life in Physical Activity Status of Individuals with and without Physical Disabilities in Saudi Arabia
Authors: Zahra Aqeela , Hassan Muhammad Shehzad , Park Jae-Hyun , Hassan Sehar-un-Nisa , Parveen Nuzhat
Published: April 2022

The promotion of physical activity (PA) in various subgroups of the population such as people with physical disabilities has been spotlighted in the revised guidelines of The World Health Organization (WHO), Geneva, Switzerland. In order to update public health interventions, there is a need to identify factors that may promote or prevent engagement in PA for special subgroups of the population. This study aims to calculate the PA levels of individuals with and without physical disabilities in Saudi Arabia, their assessment of the environmental (EQoL), and the predictive role of EQoL in PA. The International Physical Activity Questionnaire (IPAQ) and the EQoL domain in standardized WHOQoL Questionnaire were administered on both groups of the population. The study sample comprised 116 individuals with physical disabilities and 243 individuals without any form of disability as a control group. A regression analysis was performed to analyze the predictors of PA in both groups. Findings showed that among the individuals with disabilities, older people were more likely to engage in PA as compared to the younger age group (p < 0.05) and males were significantly less likely to meet the PA criteria. Some of the EQoL features such as safety increased the likelihood of PA up to 2.3 times (p < 0.05) in individuals with physical disabilities. In addition, opportunities for leisure activities were a significant predictor of PA among both groups of individuals with and without physical disabilities (p < 0.05). Our findings suggest that upcoming public health interventions should focus on improving various dimensions of EQoL for the promotion of physical activity among individuals with physical disabilities. Additional studies are needed to further explore various sociodemographic and environmental factors which can affect the PA status of disabled groups.
After-School Extracurricular Activities Participation and Depressive Symptoms in Chinese Early Adolescents: Moderating Effect of Gender and Family Economic Status
Authors: Pan Yangu , Zhou Di , Shek Daniel T. L.
Published: April 2022

Although Western studies showed that participation in extracurricular activities was intimately linked to adolescents’ psychological adjustment, very few studies have addressed this issue among early adolescents in China. Based on a nationally representative sample of 9672 Chinese junior high school students (Mage = 14.54 years, SD = 0.70 years), this study investigated the relationship between participation in different extracurricular activities and depressive symptoms among Chinese early adolescents, and the moderating role of gender and family economic status. Results indicated that time spent completing homework, attending extracurricular tutoring, and playing online games after school was positively related to students’ depressive symptoms, whereas time spent on participating in physical exercise was negatively associated with students’ depressive symptoms. Besides, the relationships between after-school activities participation and student depressive symptoms were moderated by gender and family economic status. The theoretical and practical implications for the arrangement of after-school activities for Chinese early adolescents are discussed.
Local Ties, Trans-Local Ties, and Substance Use among Rural-to-Urban Migrants in China
Authors: Chen Xi , Zhong Hua , Zhang Serena Yunran
Published: April 2022

China has witnessed unprecedented rural-to-urban migration since the early 1980s. While trying to assimilate into the city, rural-to-urban migrants still maintain close ties with their home communities. This study examines how local ties and trans-local ties of rural-to-urban migrants affect their alcohol and tobacco use. Data were obtained from the 2016 and 2018 China Labor-force Dynamics Survey, a nationally representative sample of adults aged over 15 in 29 provinces in China. Participants included 1426 rural-to-urban migrant workers and 6438 urban residents in China. We found that compared to urban natives, rural-to-urban migrants had higher tobacco use prevalence (logit = 0.19, 95% CI = [0.03, 0.35]; p < 0.05) and more frequent alcohol use (logit = 0.27, 95% CI = [0.11, 0.42]; p < 0.001) after adjusting for sociodemographic characteristics. Migrants with more local social ties engaged in more frequent drinking (having >10 local friends vs. having 0 local friends: logit = 0.58, [0.10, 1.06], p < 0.05), whereas trans-local ties were not a significant correlate. In contrast, migrants who returned to their hometown more times (an indicator of trans-local ties) were more likely to be current tobacco users (logit = 0.01, 95% CI = [0.00, 0.02], p < 0.01) after adjusting for sociodemographic variables. These findings extended the research on social networks and health behaviors by identifying how local and trans-local ties differentially affected the vulnerabilities of tobacco and alcohol use among rural-to-urban migrants in China. The findings suggested that policies and interventions on reducing migrants’ health risk behaviors should focus on the role of different types of social ties.
Social Interaction, Lifestyle, and Depressive Status: Mediators in the Longitudinal Relationship between Cognitive Function and Instrumental Activities of Daily Living Disability among Older Adults
Authors: Li Qiuhong , Wu Chao
Published: April 2022

(1) Background: Cognitive decline is associated with instrumental activities of daily living (IADL) disability. Intervention targeting the mediators of this association will provide a path to avoid cognition-related IADL disability. (2) Methods: This study used data of wave 2008 (baseline) and wave 2014 of Chinese Longitudinal Healthy Longevity Surveys. Structural equation modeling was conducted to examine the mediating effect of social interaction, lifestyle (fruit and vegetable intake; exercise habits), and depressive status on the association between four baseline cognitive function dimensions (measured by the Chinese version of the Mini-Mental State Examination) and five (2014) IADL dimensions (visiting neighbors, shopping, preparing meals, washing clothes, and taking public transportation). (3) Results: Among 1976 older adults, 29.1% developed IADL disability 6 years later. The cognition–disability association was completely mediated by social interaction (estimate = −0.095, p < 0.001), lifestyle (estimate = −0.086, p < 0.001), and depressive status (estimate = −0.017, p = 0.003). The mediating effects of social interaction (46.3% variances explained) and lifestyle (42.0% variances explained) were both larger than that of depressive status (8.3% variances explained). (4) Conclusions: The development of interventions aimed at improving social interaction, depression, and lifestyle could be of value to prevent cognition-related IADL disability.