bluuebunny/crossref_metadata_2025 huggingface dataset:
Feasibility of photon-counting computed tomography as a novel imaging modality for challenging endodontic diagnostic tasks
Authors: Fontenele Rocharles Cavalcante , Picoli Fernando Fortes , Pinto Jader Camilo , Coudyzer Walter , de Faria Vasconcelos Karla , Farias Gomes Amanda , Binst Joke , Jacobs Reinhilde
Published: April 2023

Photon-counting computed tomography (PCCT) is an innovative technological advancement in relation to x-ray detectors which offers ultra-high-resolution images. The current study aimed to evaluate the visualization ability of PCCT compared to cone-beam computed tomographic (CBCT) devices for challenging endodontic diagnostic tasks. A reference image of an anthropomorphic phantom was acquired using an industrial micro-CT device. Thereafter, the phantom was scanned with three imaging devices, which included PCCT scanner (NAEOTOM Alpha) and two CBCT devices (3D Accuitomo 170 and NewTom VGi evo) having standard and high-resolution acquisition protocols. The diagnostic tasks involved visualizing fine endodontic structures (apical delta, narrow canal, and isthmus) and root cracks. Three experienced examiners assessed the images and were blinded to the PCCT and CBCT devices. Each image was rated according to a three-grade scale (appropriate, acceptable, or inappropriate) for the diagnostic tasks. In relation to fine endodontic structures grouped together, PCCT showed similar diagnostic performance compared to the reference image (p > 0.05). As for the CBCT devices, an excellent performance was only observed with the 3D Accuitomo 170 device at a high-resolution acquisition mode (p > 0.05). The visualization of root cracks was also better with 3D Accuitomo 170 compared to other devices (p < 0.05). Overall, PCCT and 3D Accuitomo 170 at a high-resolution setting showed similar performance for visualizing fine endodontic structures. In addition, the high-resolution CBCT protocol was superior for visualizing root cracks compared to both PCCT and other standard- and high-resolution CBCT protocols.
Polypropylene microplastics promote metastatic features in human breast cancer
Authors: Park Jun Hyung , Hong Seungwoo , Kim Ok-Hyeon , Kim Chul-Hong , Kim Jinho , Kim Jung-Woong , Hong Sungguan , Lee Hyun Jung
Published: April 2023

Microplastics (MPs) are now a global issue due to increased plastic production and use. Recently, various studies have been performed in response to the human health risk assessment. However, these studies have focused on spherical MPs, which have smooth edges and a spherical shape and account for less than 1% of MPs in nature. Unfortunately, studies on fragment-type MPs are very limited and remain in the initial stages. In this study, we studied the effect that 16.4 µm fragment type polypropylene (PP) MPs, which have an irregular shape and sharp edges and form naturally in the environment, had on breast cancer. The detrimental effects of PPMPs on breast cancer metastasis were examined. Here, 1.6 mg/ml of PPMP, which does not induce cytotoxicity in MDA-MB-231, was used, and at this concentration, PPMP did not induce morphological changes or cellular migrating in the MDA-MB-231 and MCF-7 cells. However, PPMP incubation for 24 hours in the MDA-MB-231 cells significantly altered the level of cell cycle-related transcripts in an RNA-seq analysis. When confirmed by qRT-PCR, the gene expression of TMBIM6, AP2M1, and PTP4A2 was increased, while the transcript level of FTH1 was decreased. Further, secretion of the pro-inflammatory cytokine IL-6 from cancer cells was elevated with the incubation of PPMP for 12 hours. These results suggest that PPMP enhances metastasis-related gene expression and cytokines in breast cancer cells, exacerbating breast cancer metastasis.
Contrasting area and yield responses to extreme climate contributes to climate-resilient rice production in Asia
Authors: Hosokawa Nanae , Doi Yasuhiro , Kim Wonsik , Iizumi Toshichika
Published: April 2023

Climate impacts on crop production components other than yield, i.e., area and cropping intensity, remain under-studied. Here, we clarify climate-crop area relationships by analyzing subnational census area and yield data for six multi-rice cropping countries in South and Southeast Asia. Extreme climate has a greater influence on the departure of area and yield from long-term trends than the average seasonal climate; precipitation and temperature in the sowing period of the wet/rainfed season have a greater influence on variability of the total annual area than in the growing period. In 57% of the country-scenario cases showing significant changes in area and/or yield, the directions of the area and yield responses to climate are not synchronized, deriving non-significant production changes under projected climates. Climate-area relationships not only limit production shocks, but also clarify uncertainties associated with climate mitigation of agricultural land, where area markedly affects the scale of mitigation.
Inter- and intratumoral proteomics and glycosaminoglycan characterization of ALK rearranged lung adenocarcinoma tissues: a pilot study
Authors: Balbisi Mirjam , Sugár Simon , Schlosser Gitta , Szeitz Beáta , Fillinger János , Moldvay Judit , Drahos László , Szász A. Marcell , Tóth Gábor , Turiák Lilla
Published: April 2023

Lung cancer is one of the most common types of cancer with limited therapeutic options, therefore a detailed understanding of the underlying molecular changes is of utmost importance. In this pilot study, we investigated the proteomic and glycosaminoglycan (GAG) profile of ALK rearranged lung tumor tissue regions based on the morphological classification, mucin and stromal content. Principal component analysis and hierarchical clustering revealed that both the proteomic and GAG-omic profiles are highly dependent on mucin content and to a lesser extent on morphology. We found that differentially expressed proteins between morphologically different tumor types are primarily involved in the regulation of protein synthesis, whereas those between adjacent normal and different tumor regions take part in several other biological processes (e.g. extracellular matrix organization, oxidation–reduction processes, protein folding) as well. The total amount and the sulfation profile of heparan sulfate and chondroitin sulfate showed small differences based on morphology and larger differences based on mucin content of the tumor, while an increase was observed in both the total amount and the average rate of sulfation in tumors compared to adjacent normal regions.
Dual-band and dual-polarized reflective Fresnel zone plate design based on Fractal shape
Authors: Wei Lusong , Ma Chao , Liu Xingyu , Ma Hongbin , Wu Yuting , Fan Zhanchun , Huangfu Jiangtao
Published: April 2023

In this study, a dual-polarized and dual band reflective Fresnel zone plate with reconfigurable beam is proposed on the basis of fractal frequency selective surface (FSS) unit with nearly 360° phase tunability. Firstly, a new phase distribution calculation strategy based on Fresnel diffraction theory is proposed to improve the performance under certain scenarios like sparse arrays. Then, a novel fractal shape is put forward and applied to the design of the Fresnel zone plate. The introduction of the fractal structure makes the unit cell perform dual band, dual polarization and 309° phase tunability characteristics. Due to the self-symmetry of the unit cell, the proposed fractal Fresnel zone plate (FFZP) is capable of beam steering in ± 45° in both TE and TM incident waves. Besides, the proposed structure shows small performance degradation when it comes to oblique incidence up to 45°, which decreases the focal diameter ratio and profile of the proposed FFZP. The operating bandwidth of the FFZP can reach up to 700 MHz at X and Ku bands. It is applicable in a wide range of RF and microwave settings such as satellite and base station.
Detection of humoral and cellular immune response to anti-SARS-CoV-2 BNT162b2 vaccine in breastfeeding women and naïve and previously infected individuals
Authors: Cavic Milena , Nesic Andrijana , Mirjacic Martinovic Katarina , Vuletic Ana , Besu Zizak Irina , Tisma Miletic Nevena , Krivokuca Ana , Jankovic Radmila , Gavrovic-Jankulovic Marija
Published: April 2023

This study explored humoral and cellular responses to anti-SARS-CoV-2 BNT162b2 mRNA vaccine in breastfeeding women and naïve and seropositive individuals in the first six months after vaccination.Sixty-one volunteers vaccinated with two doses of the BNT162b2 mRNA vaccine were enrolled in the study. In-house developed ELISA was used for the quantification of SARS-CoV-2 RBD-specific antibodies. Cell surface marker expression and intracellular IFN-γ analysis were carried out by flow cytometry. The concentrations of IFN-γ, IL-6 and TNF were determined by ELISA. A significant rise in anti-RBD IgG antibody levels was observed 14 days after the first vaccine dose (p < 0.0001) in serum and milk. The expression of CD28 on CD4+ T cells was significantly higher compared to baseline (p < 0.05). There was a significant increase (p ≤ 0.05) in B cell lymphocyte subset after revaccination, and increased percentage of CD80+ B cells. The expression of IFN-γ in peripheral blood lymphocytes, CD3+ T cells and serum was significantly increased (p < 0.05). No significant difference in immune response was observed between breastfeeding women and other study participants. The anti-SARS-CoV-2 BNT162b2 mRNA vaccine-induced measurable and durable immune response in breastfeeding women and in naïve and previously infected individuals.
Effect of carbon spacer length on the antibacterial properties of zwitterionic poly(sulfobetaine) type copolymeric brushes and their application in wound healing
Authors: Dhingra Shaifali , Su Shih-Po , Chan Yang-Hsiang , Saha Sampa
Published: April 2023

Creating infection resistant polymer brushes possessing antiadhesive, bactericidal and cell-compatible features can be regarded as a promising approach to prevent biomaterial-associated infections.
High-energy molecular-frame photoelectron angular distributions: a molecular bond-length ruler
Authors: Vela-Peréz I. , Ota F. , Mhamdi A. , Tamura Y. , Rist J. , Melzer N. , Uerken S. , Nalin G. , Anders N. , You D. , Kircher M. , Janke C. , Waitz M. , Trinter F. , Guillemin R. , Piancastelli M. N. , Simon M. , Davis V. T. , Williams J. B. , Dörner R. , Hatada K. , Yamazaki K. , Fehre K. , Demekhin Ph. V. , Ueda K. , Schöffler M. S. , Jahnke T.
Published: April 2023

The tilt angle of the main lobe of high-energy molecular-frame photoelectron angular distributions allows for the bond-length determination of small molecules.
Citrate-coated cobalt ferrite nanoparticles for the nano-enabled biofortification of wheat
Authors: Perea-Vélez Yazmín Stefani , Carrillo-González Rogelio , González-Chávez Ma. del Carmen A. , Vangronsveld Jaco , Monasterio Iván Ortiz , Tapia Maruri Daniel
Published: April 2023

Citrate-coated cobalt ferrite nanoparticles enhance wheat's nutritional quality by improving grain yield and increasing Fe concentration, contributing to sustainable agri-food systems and combating hidden hunger.
Enantioselective Meerwein–Ponndorf–Verley reduction of β,γ-unsaturated α-keto esters by asymmetric binary-acid catalysis in the green solvent iPrOH
Authors: Qiu Huixin , Ren Jiayi , Zhang Long , Song Ran , Si Wen , Yang Daoshan , Wen Lirong , Lv Jian
Published: April 2023

Enantioselective Meerwein–Ponndorf–Verley reduction of β,γ-unsaturated α-keto esters in iPrOH alone was achieved by using asymmetric binary-acid catalysts.
Radiometallation and photo-triggered release of ready-to-inject radiopharmaceuticals from the solid phase
Authors: Śmiłowicz Dariusz , Eisenberg Shawn , Ahn Shin Hye , Koller Angus J. , Lampkin Philip P. , Boros Eszter
Published: April 2023

Chelator-mediated solid-phase capture, followed by photochemical cleavage provides radiopharmaceuticals in a ready-to-inject form for excellentin vivoperformance in a preclinical mouse model.
HKUST-1 loaded few-layer Ti3C2Tx for synergistic chemo-photothermal effects to enhance antibacterial activity
Authors: Fang Lei , Chen Yingjie , Shan Wei , Hui Tiankun , Ilham Mokni , Wu Jie , Zhou Chuanli , Yu Liangmin , Qiu Meng
Published: April 2023

NIR irradiation has enabled induced hyperthermia and the release of Cu2+ ions, causing the disruption of the bacterial membrane, resulting in cytoplasmic leakage.
Tuning quantum capacitance in 2D graphene electrodes: the role of defects and charge carrier concentration
Authors: Hassan Ayaz , Mattioli Isabela A. , Colombo Rafael N. P. , Crespilho Frank N.
Published: April 2023

Electrochemical oxidation of a graphene monolayer results in a G-band shift in the micro-Raman spectrum and an increase in the quantum capacitance, resulting from an increase in the number and density of defects and charge carrier concentration in the graphene structure.
Cost-effective, high-performance Ni3Sn4 electrocatalysts for methanol oxidation reaction in acidic environments
Authors: Boukhvalov Danil W. , D’Olimpio Gianluca , Liu Junzhe , Ghica Corneliu , Istrate Marian Cosmin , Kuo Chia-Nung , Politano Grazia Giuseppina , Lue Chin Shan , Torelli Piero , Zhang Lixue , Politano Antonio
Published: April 2023

The methanol oxidation reaction is particularly efficient with a Ni3Sn4 catalyst, and also has satisfactory durability.
Improved quantum yield in geometrically constrained tetraphenylethylene-based metal–organic frameworks
Authors: Stawiasz Katherine J. , Deneff Jacob I. , Reyes Raphael A. , Woods Toby J. , Rohwer Lauren E. S. , Valdez Nichole , Rodriguez Mark A. , Lawal Abdul , Moore Jeffrey S. , Sava Gallis Dorina F.
Published: April 2023

Linker rigidification via incorporation into two new MOF materials results in a 2.5× increase in quantum yield compared to the linker alone. Furthermore, optical properties of the resulting materials are displaying solvatochromatic effects.
Probing multimodal light emission from Tb3+/Yb3+-doped garnet nanophosphors for lighting applications
Authors: Mishra Neeraj Kumar , Shwetabh Kumar , Gautam Uttam K. , Kumar Kaushal
Published: April 2023

Herein we report the solution-combustion-method-synthesized Tb3+- and Tb3+/Yb3+-doped Gd3Ga5O12 nanophosphors, which possess luminescent and magnetic properties.
High-throughput UV-photofragmentation studies of thymine and guanine
Authors: Wang Siwen , Dauletyarov Yerbolat , Krüger Peter , Horke Daniel A.
Published: April 2023

High-throughput photofragmentation studies of thymine and guanine were performed at 257 nm and 343 nm and for a wide range of ionisation laser intensities.
Physico-geometrical kinetic insight into multistep thermal dehydration of calcium hydrogen phosphate dihydrate
Authors: Hara Masami , Koga Nobuyoshi
Published: April 2023

The multistep thermal dehydration of DCPD to form γ-CPP via DCPA is significantly controlled by the physico-geometrical constraints of the reaction.
Low-temperature deep oxidation of N,N-dimethylformamide (DMF) over CeCu binary oxides
Authors: Fonzeu Monguen Cedric Karel , Daniel Samuel , Tian Zhen-Yu
Published: April 2023

Here, we reported a ceria–copper binary oxide synthesized using the sol–gel approach, which exhibited much improved catalytic activity and stability for abating N,N-dimethylformamide (DMF) at low temperature.
Novel broadband NIR phosphors Y2Mg2Ga2Si2O12:xCr3+ for NIR LED applications
Authors: Wu Shihao , Liang Heng , Li Yan , Zou Wanfang , Liao Zhijian , Wang Wei , Ye Xinyu
Published: April 2023

The Cr3+-doped Y2Mg2Ga2Si2O12 phosphors exhibit broadband NIR emission peak at 790 nm with a FWHM of 180 nm, which have potential applications in biomedicine, food safety detection, and night vision surveillance.
(Poly)phenol intake, plant-rich dietary patterns and cardiometabolic health: a cross-sectional study
Authors: Li Yong , Xu Yifan , Ma Xuemei , Le Sayec Melanie , Wu Haonan , Dazzan Paola , Nosarti Chiara , Heiss Christian , Gibson Rachel , Rodriguez-Mateos Ana
Published: April 2023

(Poly)phenols as a mediating factor in the associations between plant rich diets and cardiometabolic diseases.
Dietary flavonoid intake is associated with a lower risk of diabetic nephropathy in US adults: data from NHANES 2007–2008, 2009–2010, and 2017–2018
Authors: Liu Fang , Nie Jiaqi , Deng Ming-gang , Yang Hongguang , Feng Qianqian , Yang Yichi , Li Xiaosong , Li Xin , Yang Xiaomeng , Li Wanting , Zhou Huanhuan , Wang Suqing
Published: April 2023

Few epidemiological studies have investigated the relationship between flavonoids and diabetic nephropathy (DN).
Structural modification of zein-based oil-in-glycerol emulsion gels for improved textural and digestion behaviors
Authors: Ma Yinguo , Lu Yao , Wang Yichuan , Gao Yanxiang , Mao Like
Published: April 2023

The current study focused on modulating the structures of zein-based emulsion gels by the addition of a surface active ingredient (Span 20, SP) to improve textural and digestion behaviors.
An information encrypted heterogeneous hydrogel with programmable mechanical properties enabled by 3D patterning
Authors: Ye Yuhang , Yu Zhengyang , Zhang Yifan , Jiang Feng
Published: April 2023

Heterogeneous architectures with defined patterns enabled by all-cellulose 3D printing ink stimulate the burgeoning development of biomimetic hydrogels for advanced applications.
Highly degenerate 2D ferroelectricity in pore decorated covalent/metal organic frameworks
Authors: Zhang Lei , Tang Cheng , Sanvito Stefano , Du Aijun
Published: April 2023

Highly degenerate 2D ferroelectricity can be realized in pore-decorated covalent/metal organic frameworks.
Toward the green synthesis of CsPbBr3perovskite nanocrystals using ethanol as an antisolvent and cyclodextrin as a ligand
Authors: Zhang Qin , Guo Fang , Zhao Run-Chi , Mo Zhi-Hong
Published: April 2023

Synthesizing halide perovskite nanocrystals at room-temperature was improved by replacing the commonly used toluene and alkylamine with non-toxic and low-cost ethanol and α-cyclodextrin, respectively, being more eco-friendly and economic than before.
Self-assembly of amino-terminated monolayers depending on the chemical structure
Authors: Rouvière Lisa , Hachin Axelle , Shinkaruk Svitlana , Hunel Julien , Aupetit Christian , Buffeteau Thierry , Genin Emilie , Vellutini Luc
Published: April 2023

Preparation of well-defined amino-terminated monolayers using a direct grafting strategy with phthalimide as a protecting amino group.
Inner transition metal-modulated metal organic frameworks (IT-MOFs) and their derived nanomaterials: a strategic approach towards stupendous photocatalysis
Authors: Panda Jayashree , Tripathy Suraj Prakash , Dash Srabani , Ray Asheli , Behera Pragyandeepti , Subudhi Satyabrata , Parida Kulamani
Published: April 2023

IT-MOFs and their derived nanomaterials: a strategic approach towards stupendous photocatalysis. This mini-review elucidates the crystal fabrication strategy, and emerging photocatalytic applications of IT-MOFs.
Ultraflexible two-dimensional Janus heterostructure superlattice: a novel intrinsic wrinkled structure
Authors: Ren Kai , Zhang Guoqiang , Zhang Lifa , Qin Huasong , Zhang Gang
Published: April 2023

The recently reported two-dimensional Janus transition metal dichalcogenide materials based assembled heterostructure superlattice presents ultra-stretchable characteristic using as nanodevices.
Tumor-targeted AIE polymeric micelles mediated immunogenic sonodynamic therapy inhibits cancer growth and metastasis
Authors: Deng Kai , Yu Yifeng , Zhao Yong , Li Jiami , Li Kunheng , Zhao Hongyang , Wu Meng , Huang Shiwen
Published: April 2023

Tumor-targeted aggregation-induced emission polymeric micelles (AIE/Biotin-M) with excellent sonosensitization and stability were first developed to mediate sonodynamic therapy and metal ion chelation for inhibiting breast cancer growth and metastasis.
Zirconium oxychloride hydrate: an efficient and reusable catalyst for retro-Claisen condensation of alcohols with 1,3-diketones
Authors: Chevella Durgaiah , Thota Chiranjeevi , Majumder Supriyo
Published: April 2023

We report an inexpensive and readily available zirconium oxychloride hydrate as a reusable catalyst for the synthesis of esters from alcohols and 1,3-diketones under solvent-free conditions.
Cu(OAc)2-catalyzed three-component cycloaddition of malonates, nitrosoarenes and alkenes: access to isoxazolidines
Authors: Wu Yuting , Liu Qiang , Huang Shuangping , Zhang Chaofeng , Wei Wenlong , Li Xing
Published: April 2023

The Cu(OAc)2-catalyzed three-component cycloaddition of malonates, nitrosoarenes and alkenes is described. Mechanistic investigations indicated that the formation of nitrone intermediates is the key step.
Influence of polymerisation conditions on the kinetics of poly(lactic-co-glycolic acid)-b-poly(ethylene glycol)-b-poly(lactic-co-glycolic acid) triblock synthesis and the occurrence of transesterification side reactions
Authors: Yan Jie , Facal Marina Paula , Blencowe Anton
Published: April 2023

Investigating how different reaction conditions influence the reaction kinetics, monomer sequence and side reactions for the synthesis of a PLGA-PEG-PLGA triblock copolymer.
Phosphonium ylide/organoaluminum-based Lewis pairs for the highly efficient living/controlled polymerization of alkyl (meth)acrylates
Authors: Chen Zhikang , Zhao Wuchao , Liu Conglei , Jiang Liuying , Fu Gang , Zhang Yuetao , Zhu Hongping
Published: April 2023

The Ph3PCHMe/AlMe(BHT)2initiator system efficiently induces the living/controlled polymerizations covering MMA, EMA, BnMA,nBuMA,nBA, and EHA monomers.
2,7-Dinitrophenanthrene-9,10-dione as a photosensitizer for the dehydrogenative lactonization of 2-arylbenzoic acids
Authors: Shi Gaochang , Wang Yi , He Min , Yu Xiaoqiang , Bao Ming
Published: April 2023

This report describes the visible-light-induced C–H/COO–H oxidative coupling reaction of 2-arylbenzoic acids to synthesize benzo-3,4-coumarins by using 2,7-dinitrophenanthrene-9,10-dione as a photocatalyst.
Synthesis, structures and reactions of acylsulfenyl iodides with theoretical investigations
Authors: Kato Shinzi , Kimura Masahiro , Komatsu Yukio , Miyagawa Kenji , Ishida Masaru , Ebihara Masahiro , Niyomura Osamu , Nakanishi Waro , Hayashi Satoko
Published: April 2023

A series of acylsulfenyl iodides (RCOSI) were synthesized by the reactions of carbothioic acid group 11–16 element derivatives with iodine or N-iodosuccinimides in moderate to good yields.
Injectable adhesive carboxymethyl chitosan-based hydrogels with self-mending and antimicrobial features for the potential management of periodontal diseases
Authors: Lin Xiaoqian , Lv Jia , Wang Desheng , Liu Kaikai
Published: April 2023

The CPM hydrogels fabricated in this work display injectability, structural stability, and high tissue adhesion in the wet and motional state, as well as self-healing features.
Thienylene combined with pyridylene through planar triazine networks for applications as organic oxygen reduction reaction electrocatalysts
Authors: Sato Kosuke , Osada Nodoka , Aihara Hidenori
Published: April 2023

Asymmetric, low-crystalline, D–π–A type layered triazine networks was exfoliated to nanosheets and used as metal-free electrochemical ORR catalyst.
Development of validated methods for the simultaneous quantification of Finasteride and Tadalafil in newly launched FDA-approved therapeutic combination: greenness assessment using AGP, analytical eco-scale, and GAPI tools
Authors: Kammoun Ahmed K. , Khayat Maan T. , Almalki Ahmad J. , Youssef Rasha M.
Published: April 2023

Green analytical methods are developed for simultaneous quantification of Finasteride and Tadalafil in new launched FDA approved capsules without prior separation. The greenness appraisal was performed using AGP, analytical eco-scale and GAPI tools.
Dimethyl sulfoxide as a function additive on halogen-free electrolyte for magnesium battery application
Authors: Gamal R. , Sheha E. , El Kholy M. M.
Published: April 2023

In this study, we design a functional halogen-free electrolyte by linking its active species with a high polarity dimethyl sulfoxide to reduce the solvation barrier of Mg2+.
Effect of cation and anion sizes of additive ionic liquid on the crystal structure of poly(vinylidene fluoride) nanofiber
Authors: Asai Hanako , Saga Hiroyuki , Saito Ryuto , Nakane Koji
Published: April 2023

We investigated the additive ionic liquid (IL) type dependence on the crystal structure of poly(vinylidene fluoride) (PVDF) nanofibers.
Solid-state synthesis of cesium manganese halide nanocrystals in glass with bright and broad red emission for white LEDs
Authors: Xu Guangyong , Wang Chuying , Li Yacong , Meng Wen , Luo Guigen , Peng Min , Xu Bin , Deng Zhengtao
Published: April 2023

Ultra-stable CsMnX3 nanocrystals embedded glasses with bright and broad red photoluminescence (PL) emission at 649 nm were synthesized as an excellent red phosphor for white light-emitting diode (LED) devices with a high color rendering index (CRI).
Protein fibrillation and hybridization with polysaccharides enhance strength, toughness, and gas selectivity of bioplastic packaging
Authors: Zhang Yeyang , Nian Yingqun , Shi Qixin , Hu Bing
Published: April 2023

Fibrillation of plant proteins and hybridization with polysaccharides enhance the strength, toughness, and gas selectivity of bioplastic film packaging for the preservation of fruits and meat.
Construction of MXene functionalized wood-based hydrogels using ZnCl2 aqueous solution for flexible electronics
Authors: Wang Zhongguo , Zhang Xiong-Fei , Shu Lian , Yao Jianfeng
Published: April 2023

Hydrogels fabricated from top-down wood nanotechnology have attracted a lot of attention.
Exploring the potential of anthracene derivatives as fluorescence emitters for biomedical applications
Authors: Aydemir Murat , Haykir Gulcin , Selvitopi Harun , Yildirim Ozge Caglar , Arslan Mehmet Enes , Abay Bahattin , Turksoy Figen
Published: April 2023

We have discovered new anthracene derivatives with strong fluorescence properties in the visible region. They exhibit high binding affinities to microtubule proteins with the potential to be used as fluorescent probes for imaging applications.
The synergistic effect of processing solvents on magnetic manipulation of orientational order and carrier transport of semiconducting polymers
Authors: Zhou Han , Fei Yuming , Ai Zhiqiang , Hui Di , Zhu Liangzheng , Pan Guoxing , Zhang Fapei
Published: April 2023

We find that processing solvents have crucial impact of on alignment dynamics of semiconducting polymers during solvent-vapor annealing under a high magnetic field (SVA-HMF).
Controlling ions and electrons in aqueous solution: an alternative point of view of the charge-transport behavior of eumelanin-inspired material
Authors: Paulin João V. , Pereira Mariane P. , Bregadiolli Bruna A. , Cachaneski-Lopes João P. , Graeff Carlos F. O. , Batagin-Neto Augusto , Bufon Carlos C. B.
Published: April 2023

Humidity- and pH-dependent current–voltage and impedance/dielectric spectroscopy shows that an electrochemical doping mechanism can dominate eumelanin's charge transport.
Optimizing the doping efficiency and thermoelectric properties of isoindigo-based conjugated polymers using side chain engineering
Authors: Tsai Chia-Hao , Lin Yan-Cheng , Wu Wei-Ni , Tung Shih-Hung , Chen Wen-Chang , Liu Cheng-Liang
Published: April 2023

Three isoindigo–bithiophene conjugated polymers named P(Si–Si), P(Si–O), and P(Si–F) with the symmetric carbosilane and asymmetric carbosilane/oligoether, and carbosilane/semifluorinated side chains are investigated for thermoelectric application.
The dinitrobenzamide mustard prodrugs, PR-104A and SN27686, for use in a novel MNDEPT cancer prodrug therapy approach
Authors: Ball Patrick , Thompson Emma , Anderson Simon , Gwenin Vanessa , Ashoorzadeh Amir , Smaill Jeff , Gwenin Chris
Published: April 2023

Directed enzyme prodrug therapy is a highly promising anti-cancer strategy. However, the current technology is limited by inefficient prodrug activation and the dose-limiting toxicity associated with the prodrugs being tested; to overcome these limitations, the dinitrobenzamide mustard prodrugs, PR-104A and SN27686, have been developed. The present study will assess both of these prodrugs for their potential uses in a novel magnetic-nanoparticle directed enzyme prodrug therapy strategy by determining their kinetic parameters, assessing the products formed during enzymatic reduction using HPLC and finally their ability to cause cell death in the ovarian cancer cell line, SK-OV-3. It was shown for the first time that the dinitrobenzamide mustard prodrugs are able to be reduced by the genetically modified nitroreductases, NfnB-cys and YfkO-cys, and that these enzyme/prodrug combinations can induce a significant cell death in the SK-OV-3 cell line, highlighting the potential for both enzyme/prodrug combinations for use in magnetic-nanoparticle directed enzyme prodrug therapy.
N-glycan breakdown by bacterial CAZymes
Authors: Crouch Lucy I.
Published: April 2023

The modification of proteins by N-glycans is ubiquitous to most organisms and they have multiple biological functions, including protecting the adjoining protein from degradation and facilitating communication or adhesion between cells, for example. Microbes have evolved CAZymes to deconstruct different types of N-glycans and some of these have been characterised from microbes originating from different niches, both commensals and pathogens. The specificity of these CAZymes provides clues as to how different microbes breakdown these substrates and possibly cross-feed them. Discovery of CAZymes highly specific for N-glycans also provides new tools and options for modifying glycoproteins.
Near-IR and optical radial velocities of the active M dwarf star Gl 388 (AD Leo) with SPIRou at CFHT and SOPHIE at OHP
Authors: Carmona A. , Delfosse X. , Bellotti S. , Cortés-Zuleta P. , Ould-Elhkim M. , Heidari N. , Mignon L. , Donati J. F. , Moutou C. , Cook N. , Artigau E. , Fouqué P. , Martioli E. , Cadieux C. , Morin J. , Forveille T. , Boisse I. , Hébrard G. , Díaz R. F. , Lafrenière D. , Kiefer F. , Petit P. , Doyon R. , Acuña L. , Arnold L. , Bonfils X. , Bouchy F. , Bourrier V. , Dalal S. , Deleuil M. , Demangeon O. , Dumusque X. , Hara N. , Hoyer S. , Mousis O. , Santerne A. , Ségrasan D. , Stalport M. , Udry S.
Published: April 2023

Context. The search for extrasolar planets around the nearest M dwarfs is a crucial step toward identifying the nearest Earth-like planets. One of the main challenges in this search is that M dwarfs can be magnetically active and stellar activity can produce radial velocity (RV) signals that could mimic those of a planet.

Aims. We aim to investigate whether the 2.2-day period observed in optical RVs of the nearby active M dwarf star Gl 388 (AD Leo) is due to stellar activity or to a planet that corotates with the star as suggested in the past.

Methods. We obtained quasi-simultaneous RVs of Gl 388 from 2019 to 2021 with SOPHIE, the optical échelle spectrograph (R ~75k) at the Observatoire de Haute-Provence in France, and RV and Stokes V measurements with SPIRou, the near-infrared spectropolarimeter at the Canada France Hawaii Telescope (R ~70k).

Results. The SOPHIE RV time series (precision of 3–5 m s−1 per visit) displays a periodic signal with a 2.23 ± 0.01 day period and 23.6 ± 0.5 m s−1 amplitude, which is consistent with previous HARPS observations obtained in 2005–2006. The SPIRou RV time series (precision of 2 ms−1 per visit) is flat at 5 ms−1 rms and displays no periodic signals. RV signals of amplitude higher than 5.3 m s−1 at a period of 2.23 days can be excluded with a confidence level higher than 99%. Using the modulation of the longitudinal magnetic field (Bℓ) measured with SPIRou as a proxy of stellar rotation, we measure a rotation period of 2.2305 ± 0.0016 days.

Conclusions. SPIRou RV measurements provide solid evidence that the periodic variability of the optical RVs of Gl 388 is due to stellar activity rather than to a corotating planet. The magnetic activity nature of the optical RV signal is further confirmed by the modulation of Bℓ with the same period. The SPIRou campaign on Gl 388 demonstrates the power of near-infrared RV to confirm or infirm planet candidates discovered in the optical around active stars. Our SPIRou observations additionally reiterate how effective spectropolarimetry is at determining the stellar rotation period from the variations of Bℓ.
The gas mass reservoir of quiescent galaxies at cosmic noon
Authors: Blánquez-Sesé D. , Gómez-Guijarro C. , Magdis G. E. , Magnelli B. , Gobat R. , Daddi E. , Franco M. , Whitaker K. , Valentino F. , Adscheid S. , Schinnerer E. , Zanella A. , Xiao M. , Wang T. , Liu D. , Kokorev V. , Elbaz D.
Published: April 2023

We present a 1.1 mm stacking analysis of moderately massive (log(M*/M⊙) = 10.7 ± 0.2) quiescent galaxies (QGs) at ⟨z⟩∼1.5, searching for cold dust continuum emission, which serves as an excellent tracer of dust and gas mass. Using both the recent GOODS-ALMA survey, as well as the full suite of ALMA Band-6 ancillary data in the GOODS-S field, we report the tentative detection of a dust continuum equivalent of the dust mass log(Mdust/M⊙) = 7.47 ± 0.13 and gas mass log(Mgas/M⊙) = 9.42 ± 0.14. The emerging gas fraction is fgas = 5.3 ± 1.8%, consistent with the results of previous stacking analyses based on lower resolution sub(mm) observations. Our results support the scenario where high-z QGs exhibit a larger fgas value by one order of magnitude compared to their local counterparts and have experienced quenching with a non-negligible gas reservoir in their interstellar medium, namely, with gas retention. Our subsequent analysis yields an anti-correlation between the fgas and the stellar mass of QGs, especially in the high-mass end where galaxies reside in the most massive halos. The fgas − M* anti-correlation promotes the selection bias as a possible solution to the tension between the stacking results pointing towards gas retention in high-z QGs of moderate M* and studies of individual targets that favour a fully depleted ISM in massive (log(M*/M⊙) > 11.2) high-z QGs.
Molecular dynamics simulations of CO2 clathrate hydrate in the presence of organic components
Authors: Sinehbaghizadeh S. , Saptoro A.
Published: April 2023

As the major greenhouse gas emission, releasing CO2 through human activities has already devastating consequences on the planet. In this context, hydrate-based (HB) techniques in favour of CO2 capture, sequestration, or utilization (CCSU) are perceived to be a novel option to arrest increasing concentrations of CO2 in the atmosphere. The end uses of captured CO2 encompass its utilization for different realms of industry such as food and beverage manufacturing plants; water desalination; metal fabrication plants; and secondary refrigeration. To offset the cost of CO2 capture as well as generating revenue, the increasing effectiveness of aforesaid techniques is crucial. Although HB approaches are faced with several limitations, the solution would be the inclusion of organic promoters which are classified as environmentally-friendly substances. However, the microscopic influences of such components on CO2 hydrates are mostly unexplored. This work highlights the CO2 clathrate hydrate stability and decomposition in the existence of organic additives through classical molecular dynamics (MD) simulations. The results can help to understand the molecular mechanisms involved in such CO2 hydrate systems which may also aid to find the more efficient organic promoters for HB applications.
Portfolio Construction with K-Means Clustering Algorithm Based on Three Factors
Authors: Aslam Bilal , Bhuiyan Rubaiyat Ahsan , Zhang Changyong
Published: April 2023

Constructing a portfolio from a large number of active stocks is a critical as well as challenging investment decision due to high volatility and biased decision making. The abundance and availability of _nancial data gives machine learning (ML) an advantage to optimize investment decisions. The k-means algorithm is used to cluster observations into di_erent groups, each of which contains those with similar properties. In this paper, three factors are considered to cluster stocks and select clusters with best performing stocks for portfolio construction. It enhances the cardinal investment decision of stock selection to construct optimized portfolios. The out-of-sample performance demonstrates high economic gains from the proposed strategy with an average Sharpe ratio of 0.7.
Nächtliche sympathische Aktivität und subjektive
Symptome nach sport-assoziierter Concussion: eine Pilotstudie
Authors: Delling Anne Carina , Jakobsmeyer Rasmus , Christiansen Nele , Coenen Jessica , Reinsberger Claus
Published: April 2023

Einleitung Eine sport-assoziierte Concussion (saC) ist eine oftmals
unterschätzte Hirnverletzung, die vor allem in Kontakt- und
Kollisionssportarten häufig vorkommt. SaCs können zu einer
Vielzahl an klinischen Symptomen führen. Akute und zum Teil die
klinische Regeneration überdauernde parasympathische Inhibierung im
Autonomen Nervensystem (ANS) wurde nach saC bereits häufig beschrieben.
Über Veränderungen im sympathischen Nervensystem ist jedoch noch
wenig bekannt. Diese wurden durch Messungen der elektrodermalen
Aktivität (EDA) im Schlaf, der erheblich zur Regeneration nach saC
beiträgt, sowie im Zusammenhang mit subjektiven Symptomen nach saC im
Rahmen einer Pilotstudie untersucht.

Methode 18 Sportler und Sportlerinnen mit diagnostizierter saC und 18 nach
Alter, Geschlecht, Größe, Gewicht, Sportart und Leistungsklasse
gematchte Kontrollathleten und -athletinnen trugen in den Nächten
während der individuellen Return-to-Sport (RTS) Phase sowie drei Wochen
nach Abschluss des RTS (postRTS) einen Handgelenkssensor (E4 Empatica Inc.,
Mailand, Italien). Anteile nächtlicher tonischer (meanEDA) und
phasischer (EDRs, Schlafstürme) EDA wurden zwecks Gruppenvergleich
ermittelt und mit saC-Symptomen (SCAT5) sowie dem subjektiven Erholungszustand
nach Schlaf mittels Mann-Whitney U-Tests oder ungepaarten t-Tests
verglichen.

Ergebnisse Während und nach dem RTS konnten keine
Gruppenunterschiede in den nächtlichen EDA-Parametern nachgewiesen
werden. Eine höhere meanEDA während des RTS korrelierte mit
einer höheren Anzahl an Symptomen (p=0,025, r=0,525) und
eine erhöhte phasische EDA mit einem geringeren Anstieg des subjektiven
Erholungszustands von vor zu nach Schlaf (EDRs: p=0,007,
r=−0,642; EDRs/min: p>0,001,
r=−0,762; Schlafstürme: p=0,011,
r=−0,616).

Fazit Die nächtliche EDA nach saC unterschied sich während
und nach dem RTS nicht signifikant zu gematchten Kontrollsportlern und
-sportlerinnen. Der Zusammenhang zwischen höherer EDA während
des RTS und der Anzahl an saC-Symptomen sowie der geringeren subjektiven
Erholung nach Schlaf könnte sowohl ursächlich für als
auch Effekt der subjektiven Symptome sein und sollte durch Baseline-Messungen
und in Kombination mit parasympathischen Markern künftig weiter
untersucht werden.
Scientific Support Active City: Eine theoriegeleitete Bedarfsanalyse
zur städtischen Bewegungsförderung
Authors: Schumacher Nils , Bischoff Laura L. , Schäfer Ines , Obi Nadia , Fertmann Regina , Reer Rüdiger , Blankenberg Stefan
Published: April 2023

Einleitung Die positive Wirkung von Bewegung für die Gesundheit
ist gut belegt. Dennoch scheinen städtische Maßnahmen zur
Förderung der körperlichen Aktivität bisher nicht
ausreichend erfolgreich umgesetzt zu werden. Ziel des vorliegenden Artikels ist
die detaillierte Darstellung einer Bedarfsanalyse zur Förderung der
körperlichen Aktivität im Rahmen des Projektes
„Scientific Support Active City“ in Hamburg.

Methodik In Anlehnung an den Intervention Mapping (IM) Ansatz wird
zunächst eine systematische Bedarfsanalyse in fünf Schritten
durchgeführt. Hierzu werden (1) Verantwortlichkeiten der
Akteur*innen festgelegt, (2) Zielgruppen definiert und (3)
verfügbare Datenquellen gesichtet, erfasst und geprüft. Auf
dieser Basis sollen (4) Prävalenzen körperlicher
Aktivität für die Zielgruppen dargestellt, (5) Ziele
konkretisiert und erste Handlungsempfehlungen abgeleitet werden.

Ergebnisse Nach Definition eines Kernteams sowie eines erweiterten
Akteursnetzwerkes wurden für die Zielgruppen Kinder und Jugendliche,
Erwachsene und ältere Erwachsene verfügbare Datenquellen
identifiziert, die im Sinne eines Multi-Source Ansatzes zur Analyse des
Bewegungsverhaltens genutzt werden können. Die zielgruppenspezifische
Analyse verdeutlicht den Bedarf an weiteren repräsentativen Daten sowie
Fördermaßnahmen z. B. für Frauen mit niedriger
Bildung und Kindern aus sozio-ökonomisch schlechter gestellten
Regionen.

Schlussfolgerung Der IM-Ansatz hat sich in der Ausgestaltung der
Bedarfsanalyse des Projektes „Scientific Support Active City“
als anwendbar erwiesen. Die initiierte Zusammenarbeit des Netzwerkes sowie der
Evidenz basierte Ansatz zur Ableitung erster Bedarfe scheinen einen
erfolgsversprechenden Ansatz zur Förderung der körperlichen
Aktivität darzustellen. Eine langfristige städtische
Gesamtstrategie für die Bewegungsförderung auf der Basis
kooperativer wissensbasierter Zielfindung kann damit kurzfristige Einzelprojekte
ablösen.
Repurposing of FDA Approved Drugs and Neuropep peptides as Anticancer
Agents Against ErbB1 and ErbB2
Authors: Patnaik Sunil Kumar , Swaroop Akey Krishna , Naik Mudavath Ravi , Selvaraj Jubie , Chandrasekar Moola Joghee Nanjan
Published: April 2023

ErbB1 and ErbB2 are the most important biological targets in cancer drug
discovery and development of dual inhibitors for the cancer therapy. FDA
approved drugs and Neuropep peptides were used to fit into the ATP binding site
of the tyrosine kinases; ErbB1 and ErbB2 proteins. Cytoscape, iGEMDOCK, HPEPDOCK
and DataWarrior softwares were used to study the role of these agents as
anticancer drugs. Eleven FDA approved drugs and eleven Neuropep peptides showed
the strongest 2D interactions and significant binding energy with the proteins.
Invitro MTT anticancer assay revealed that, the test compounds,
peptide YSFGL and doxorubicin showed significant IC50 value
(µM) of 26.417±0.660 and 7.675±0.278 respectively which
are compared with the lapatinib standard IC50 value (µM) of
2.380±0.357 against A549 cells and IC50 value (µM) of
39.047±0.770 and 8.313±0.435 respectively which are compared
with the lapatinib standard IC50 value (µM) of
3.026±0.180 against MDA-MB-231 cells.
Training zur Behandlung von Rückenschmerzen – ein
Überblick zum Stand der Wissenschaft und Perspektiven
Authors: Engel Tilman , Risch Lucie , Mayer Frank
Published: April 2023

Rückenschmerzen sind weit verbreitet und weltweit eine der
führenden Ursachen für eine eingeschränkte
körperliche Funktion und Belastbarkeit. Training und Bewegung
zählen neben kognitiver Verhaltenstherapie und Edukation zu den
First-Line-Treatments, vor allem bei chronischen nicht-spezifischen
Rückenschmerzen. Die Wirksamkeit von Training kann anhand von
Einzelstudien sowie RCTs und Metaanalysen belegt werden. Dabei zeigt sich, dass
Training anderen konservativen Behandlungsformen überlegen ist.
Evidenz-basiert lässt sich derzeit keine spezifische Trainingsform als
am wirksamsten identifizieren. Es zeigt sich jedoch wiederholt, dass vor allem
Trainingsprogramme, die sowohl die (senso)motorische Kontrolle und
Stabilisationsfähigkeit als auch die Kräftigung des Rumpfes in
den Fokus legen, sich als besonders geeignet zur Reduktion der Schmerzen und der
damit verbundenen Einschränkungen erweisen. Messbare
neuromuskuläre Defizite im Zusammenhang mit Rückenschmerzen
untermauern dabei die Bedeutung des Trainings der reaktiven motorischen
Kontrolle, vor allem in Situationen mit plötzlichen Lasteinwirkungen.
Allerdings lassen sich derzeit evidenz-basierte Empfehlungen zur Dosis-Wirkung
nur begrenzt ableiten. Schließlich ist die Notwendigkeit einer
möglichen Individualisierung des Trainings zu klären.
Multiple Small Bowel Intussusceptions in the Setting of Anabolic Steroid Use
Authors: Davies Alex , Sangiorgio Michael , Patwardhan Ashwin
Published: April 2023

Adult intussusception is a rare phenomenon and often provides a unique diagnostic challenge, typically involving extensive investigation to rule out sinister pathology. We present the case of a healthy 28-year-old male, who presented with symptoms suggestive of small bowel obstruction. Computed tomography displayed evidence of a small bowel intussusception; however, thorough investigation was unremarkable, besides a marked polycythemia. The patient represented several months later with another bowel obstruction, at which time he disclosed the regular use of androgenous anabolic steroids (AAS), which are recognized to induce polycythemia. AAS increase the risk of thromboembolic events and have more recently been implicated as a risk factor for intussusception. This case aims to highlight the increasing prevalence of AAS use, and the importance of its consideration in diagnostic dilemmas, particularly in otherwise healthy adults presenting with intussusception.
Role of Morphology in the Diagnosis of Acute Leukemias: Systematic Review
Authors: Sekar Mithraa Devi , Raj Manasa , Manivannan Prabhu
Published: April 2023

The role of hematopathologists in the diagnosis of acute leukemia (AL) starts with the morphological examination of either peripheral blood smear or bone marrow. The morphological hallmark for the myeloblast includes “Auer rods” and “Phi bodies.” The addition of cytochemical stains such as myeloperoxidase, Sudan Black B, periodic acid-Schiff stain, nonspecific esterase, and Perls' stain acts as an important adjunct to the morphological classification in the resource-constrained settings. The recent World Health Organization classification still endorses the utility of morphology which requires the presence of either ≥ 20% lymphoblasts or myeloblasts/or its equivalents (monoblasts, promonocytes, or megakaryoblasts) and integrates it with the clinical features, immunophenotyping (IP), and molecular genetics for making the diagnosis of AL. Morphology can give clue to the specific diagnosis of acute myeloid leukemia (AML) with t(8:21), t(15:17), t(16:16), or inv(16) and this diagnosis can be made irrespective of blasts count if such translocations are demonstrated by molecular tests. There are some interesting findings such as blasts with “hand-mirror” morphology, nuclear cleavage, prominent cytoplasmic vacuoles, pseudo-Chediak-Higashi granules, cup-like nucleus, and other dysplastic features helping in differentiating lymphoid and myeloid leukemias. Transient abnormal myelopoiesis in Down syndrome and hypoplastic AL can be picked up on morphological examination. Bone marrow biopsy would be greatly beneficial and complementary to aspirate smears and is required for diagnosing exact cellularity, topography of cells, dyspoiesis, myelonecrosis, gelatinous marrow transformation, myelofibrosis, and IP can be performed using immunohistochemistry. Morphological examination in AL is not only helpful for diagnosis but also useful for predicting the prognosis in posttherapy cases, AML with myelodysplasia-related changes, therapy-related myeloid neoplasms, and mixed phenotype AL. Hematogones, blastoid mantle cell lymphoma, high grade B cell lymphoid with blastoid morphology, Burkitt leukemia, prolymphocytes in prolymphocytic leukemia, hairy cell leukemia variant, plasmablasts especially in plasmablastic leukemia, or plasma cell leukemia can mimic AL and IP is useful in these situations. Hence, morphology should be considered as a kind of “gold-standard” starting point for the analysis of AL cases. Morphological examination cannot be replaced and advanced tests cannot be used as surrogate for morphology.