bluuebunny/crossref_metadata_2025 huggingface dataset:
A COMPARATIVE STUDY OF HOMOCYSTEINE, CYANOCOBALAMINE, FOLATE, LIPID PROFILE AND SERUM CREATININE LEVEL IN HYPERTHYROID SUBJECTS BEFORE AND DURING TREATMENT
Authors:   Associate Professor, Department of Biochemistry, J.L.N. Medical College, Ajmer (Rajasthan)., Tanwani Kamlesh
Published: June 2022

Introduction: Hyperthyroidism disorder results from over production of hormones secreted by thyroid gland itself. The present study plan to delineate influence of thyroxin on homocysteine, folate, cyanocobalamine, lipid profile and serum creatinine in hyperthyroid patients before and during treatment with antithyroid drugs. Material and Method: The present study was conducted on 75 pateints of hyperthyroidism of either sex in department of biochemistry, J.L.N. medical college and hospitals, Ajmer. Serum homocysteine, cyanocobalamine, folate level was measured by ELISA while thyroid function test were evaluated by RIA method. Result and discussion: There were significant change in homocysteine, folate, cyanocobalamine, total cholesterol, HDL-cholesterol and LDL-cholesterol in hyperthyroid subjects before and during treatment (P<0.0001) and these emerging evidence suggest that these parameter are influenced by level of thyroxine hormone which were higher in hyperthyroid subjects before treatment with antithyroid drugs. Conclusion: It is concluded that treatment with antithyroid drug reduces the level of thyroxine hormone in hyperthyroid subject increases level of homocysteine and causes dyslipidemia which increases risk of coronary artery disease, angina pectoris in subclinical hyperthyroidism.
RUPTURE SPONTANEE DE LA RATE : A PROPOS DUN CAS
Authors:   Service de Chirurgie Viscerale, Hopital Ibn Tofail CHU Mohammed VI., Habbab A. , Matsimouna D. ,   Service de Chirurgie Viscerale, Hopital Ibn Tofail CHU Mohammed VI., Outouzalt A. ,   Service de Chirurgie Viscerale, Hopital Ibn Tofail CHU Mohammed VI., Hamri A. ,   Service de Chirurgie Viscerale, Hopital Ibn Tofail CHU Mohammed VI., Narjis Y. ,   Service de Chirurgie Viscerale, Hopital Ibn Tofail CHU Mohammed VI., Benelkhaiat R. ,   Service de Chirurgie Viscerale, Hopital Ibn Tofail CHU Mohammed VI.
Published: June 2022

Les ruptures non traumatiques ou spontanees de la rate (RNTR) sont des entites rares mais potentiellement mortelles. La mortalite de cette affection est essentiellement liee au retard diagnostique et therapeutique, ainsi quaux risques lies au terrain et a la gravite de la pathologie sous-jacente. Elles necessitent dans la majorite des cas une splenectomie. Elles peuvent survenir soit sur une rate macroscopiquement saine, par exemple au cours dune mononucleose infectieuse (MNI) ou dun acces palustre ou sur une rate pathologique par exemple tumorale mai aussi dans certaines coagulopathies. Dans notre cas il sagit dun patient de 35ans suivi pour une LMC admis pour douleurs abdominales diffuses brutales, une paleur cutaneo-muqueuse avec un etat hemodynamique instable. Le bilan biologique a revele une anemie normochrome macrocytaire le diagnostic de confirmation de la rupture etait realise par lechographie et le scanner abdominal. Vu linstabilite de letat hemodynamique, la decision dune splenectomie a ete prise avec transfusions per-operatoire de 2 culots globulaires. Levolution etait favorable.
CSR AND PERFORMANCE: TWO SUBSTITUTABLE CONCEPTS FOR MEASURING ORGANIZATIONAL REALITIES: A THEORETICAL APPROACH
Authors: Bakirdi Zakaria EL , Lotfi Benazzou
Published: June 2022

The objective of this article is to study the contribution of CSR in relation to the neighbouring but much older concept of performance. The emergence of CSR embodies an evolution of the company whose borders are becoming increasingly permeable and evolving. The firmÂ’s conception based on the existence of formal property rights is thus undermined by the existence of cooperation strategies, alliances, the use of outsourcing, and more generally by an increasing interdependence with all its stakeholders. The main consequence of this development is the extension of the scope of the companyÂ’s responsibility, including legal responsibility, to all the companyÂ’s stakeholders, thus influencing the notion of performance. - The first part of this paper presents in a synthetic way the concept of CSR and in particular its foundations and its variations. - The second part brings together the concepts of performance and CSR, highlighting their convergences and oppositions. Even if these two concepts diverge theoretically, their purposes being different, the tools for measuring performance and the degree of consideration of the social responsibility of firms seem quite similar.
STAKEHOLDER THEORY IN PERSPECTIVE
Authors: Bakirdi Zakaria EL , Lotfi Benazzou
Published: June 2022

Referring to a stakeholder theory means underlining a correlation between facts and conceptualization (part 1) as well as the necessary passage from a flat reading, which would be a sort of panorama of texts and positions (part 2), to a thick reading, focused on understanding its foundations.
GOOD CLINICAL PRACTICE IN PHARMACOVIGILANCE
Authors:   School Of Pharmacy, Career Point University, Hamirpur, Himachal Pradesh, INDIA 176041., Devi Rajni , Devi Anjana ,   School Of Pharmacy, Career Point University, Hamirpur, Himachal Pradesh, INDIA 176041., Kumar Sanjay ,   School Of Pharmacy, Career Point University, Hamirpur, Himachal Pradesh, INDIA 176041., Jeet Kamal ,   School Of Pharmacy, Career Point University, Hamirpur, Himachal Pradesh, INDIA 176041., Sharma Tanuj ,   School Of Pharmacy, Career Point University, Hamirpur, Himachal Pradesh, INDIA 176041., Sharma Sumanshu ,   School Of Pharmacy, Career Point University, Hamirpur, Himachal Pradesh, INDIA 176041., Dhiman Anjali ,   School Of Pharmacy, Career Point University, Hamirpur, Himachal Pradesh, INDIA 176041., Kumar Manish ,   School Of Pharmacy, Career Point University, Hamirpur, Himachal Pradesh, INDIA 176041.
Published: June 2022

Clinical research is a mechanism or a process that provides convincing evidence that the new treatments or therapies suggested are safe and effective. The ultimate aim of clinical research is the identification and discovery of contemporary diagnostic methods as well as the establishment of advanced standards of medicine. Good Clinical Practice (GCP) is an ethical and scientific quality standard for designs, operations and recordings involving the participation of human subjects. Accompanying the Guidelines pledges to the public that the ethics, integrity and welfare of humans participating in the trials are protected. India has experienced distinct opportunities for clinical trials for clinical trials compared to ethical patients, major medical institutions with fewer and more equipped investigators and fewer patient voices than regulated countries, with larger patient counts. However, our Indian guidelines were needed to ensure a uniform standard of clinical research across the country and to provide data for registration for new drugs before use in the human population in India. Junctions guidelines were developed by a complete committee set up by CDSCO with clinical experts. This article explains the importance of good clinical practice from an Indian clinical research perspective, while defining and outlining the goals and objectives of the GCP. It addresses the historical events that led to the emergence of good clinical practices and examines the current scenario with respect to the application of GCPs in clinical trials in India. Finally, the article addresses the challenges to maintaining a best and competitive system and will suggest a way forward to increase the credibility and efficiency of good clinical practice in clinical research.
A GENDER PERSPECTIVE ON SOLID WASTE MANAGEMENT PRACTICES: A CLIMATE CHANGE MITIGATION INITIATIVE
Authors: R. Cruzada Jr. , DPA Rolando , Benedictos Erwin
Published: June 2022

This study assessed the extent of involvement of rural women in climate change mitigation initiative through solid waste management practices conducted during the calendar year 2020 in the eight lakeshore towns in the 4th District of Laguna. The study employed descriptive-quantitative correlational design. Employment influenced the extent of involvement of rural women in climate change mitigation initiative in terms of solid management practices who favored that environmental education be taught in schools and educating about proper garbage management to fix garbage crisis, and insisting the local government put recycling laws and program in place. Moreover,they had stance on using alternative energy source such as windmills, solar power and others, learning to make right practical decisions for adapting to climate change, and learning more on climate change response strategy and promoting them to others. Consequently, rural women had utmost involvement in climate change mitigation initiative about health risk related to burning garbage, illegal dumps polluting rivers, streams and wells and about flooding due to garbage blocking drains and gullies.
VISCERAL EMERGENCIES AND PREGNANCYA CASE SERIES OF 11 CASES AND LITERATURE REVIEW
Authors:   Gynecology and Obstetrics Department, Mohammed VI University Hospital, Mohammed First University Oujda, Morocco., Anass Mettahri , Harcha Kamal El ,   Gynecology and Obstetrics Department, Mohammed VI University Hospital, Mohammed First University Oujda, Morocco., Hafsa Taheri ,   Gynecology and Obstetrics Department, Mohammed VI University Hospital, Mohammed First University Oujda, Morocco., Hanane Saadi ,   Gynecology and Obstetrics Department, Mohammed VI University Hospital, Mohammed First University Oujda, Morocco., Ahmed Mimouni ,   Gynecology and Obstetrics Department, Mohammed VI University Hospital, Mohammed First University Oujda, Morocco., Rachid Jabi ,   Gynecology and Obstetrics Department, Mohammed VI University Hospital, Mohammed First University Oujda, Morocco., a Bouzianemohammed ,   Gynecology and Obstetrics Department, Mohammed VI University Hospital, Mohammed First University Oujda, Morocco.
Published: June 2022

Surgical digestive emergencies during pregnancy represent a Situation far from being exceptional, their frequency is of the order of 2/1000pregnancies.They are dominated by appendicitis, acute cholecystitis, occlusion acute bowel disease and acute pancreatitis. The occurrence of these abdominal surgical emergencies in a pregnant woman Constitutes a challenge for the practitioners concerned because obtaining the correct diagnosis can be difficult due to the normal physiological and anatomical changes that occur during pregnancy. A visceral surgeon cannot therefore envisage the surgical management of a pregnant woman only in a multidisciplinary and joint way, requiring work team between different specialties, and integrating at each stage a gynecologist-obstetrician and the patient. Laparoscopy is a satisfactory option. The action to be taken in the face of these pathologies must be well codified, the first goal being to avoid hypoxia and maternal hypotension, which directly interfere with the fatal prognosis. As a rule, the condition of the mother should always take priority because treatment appropriate from the mother will generally be beneficial to the fetus itself. The maternal-fetal prognosis islinked to the severity of the visceral pathology.
CASE REPORT: UNEXPECTED OUTCOME IN PATIENT WITH LIVER TRANSPLANT WITH COVID 19 PNEUMONIA
Authors:   Internal Medicine Unit/Gastroenterology, Hatta Hospital, Dubai, United Arab Emirates., Khaled Abou El Foul Rami , Mahmoud Ibrahim Mohamed Mohamed ,   Internal Medicine Unit/Gastroenterology, Hatta Hospital, Dubai, United Arab Emirates., Mustafa Quraishy Nael ,   Internal Medicine Unit/Gastroenterology, Hatta Hospital, Dubai, United Arab Emirates., Mohamed Bakri Hammoda Hoda ,   Internal Medicine Unit/Gastroenterology, Hatta Hospital, Dubai, United Arab Emirates., Gomah Hamed Alaqqad Mohamed ,   General Surgery Department, Hatta Hospital, Dubai, United Arab Emirates., Abdelfattah Elmowafi Badran Reda ,   General Surgery Department, Hatta Hospital, Dubai, United Arab Emirates., Abouelfetouh Abouelfetouh Elsharkawi Mohamed ,   Accident and Emergency department, Hatta Hospital, Dubai, United Arab Emirates., Samir Mokhtar Hamed Elwan Mohammed ,   Radiology department, Hatta Hospital, Dubai, United Arab Emirates., Syed Rezzek Manal ,   Internal Medicine Unit/Gastroenterology, Hatta Hospital, Dubai, United Arab Emirates.
Published: June 2022

Coronavirus disease-2019 (COVID-19) is a global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The outcomes and severity of COVID-19 are dependent on comorbidities such as diabetes mellitus, cardiovascular diseases including hypertension, kidney disease, pulmonary disease, and age[1,2,3]Since December 2019, the whole world suffers from (SARS-CoV-2) that was declared by the World Health Organization (WHO) as a global pandemic on March 11, 2020[4]Liver transplant (LT) recipients, being immunosuppressed, are prone to severe infections [5]. Therefore, the presence of comorbidities and chronic immunosuppression may increase the risk of severe COVID-19 among liver transplant recipients [6],[7].
INFLUENCE OF 50 METER DRILL OF DIFFERENT INTENSITY TRAINING ON ANAEROBIC CAPACITY OF MALEKHO-KHO PLAYERS
Authors:   Assistant Professor, Department of Physical Education & Sport Science, Visva-Bharati, Santiniketan, India., Chatterjee Kallol , Das Mrinal ,   Assistant Teacher in Physical Education, Burda High School, Baghmundi, Purulia, India.
Published: June 2022

Purpose: Aim of the study was to investigate the influence of 50 meter drill of different intensity training on anaerobic capacity of male Kho-Kho players. Method: Pre test - Post test Purposive Design was used by which total thirty two (N=32) male Kho-Kho players (Age: 17.66 + 1.34 years, BMI: 20.04 + 1.36 kg/m2, Resting Heart Rate: 74.44 + 1.44 beats/min., Training Age: 3.78 + 0.75 years) were purposively selected and assigned into four equal groups: HIITG (n=8), MIITG (n=8), CHMIITG (n=8) and ACG (n=8). Anaerobic Capacity (Unit: Watts) was assessed by Running Based Anaerobic Sprint Test (RAST) before and after the completion of eight weeks 50 meters drill of different intensity interval training. Data analysis methods were descriptive statistics: Mean, Standard Deviation and Standard Error, inferential statistics: 2-tailed One-Way ANCOVA with Bonferroni Post-Hoc test and normality test: Shapiro-Wilk test respectively performed on IBM SPSS software (Version: 25). The alpha (Î±) level was set at pâ‰¤0.05 for significance, whereas the effect size was reported with the 95% confidence for all analyzed measures. Result:The results shown that there was significant (p<0.05) increases in anaerobic capacity (Power in Watts) for each experimental groups (EG) in comparison to active control group (ACG). Conclusion:The present results indicate that eight (8) weeks 50 meter drill of different intensity interval training showed an increase in anaerobic capacity of senior state level male Kho-Kho players. Not only HIIT is better and beneficial than MIIT, but also CHMIIT too is better and beneficial than MIIT.
SERUM FERRITIN LEVEL IN PATIENTS WITH ACUTE HAEMORRAGIC STROKE AND ITS ASSOCIATION WITH OUTCOME
Authors:   Post Graduate Trainee, Department Of Medicine, Jorhat Medical College Hospital, Jorhat, Assam., Kulbinder Singh , AK Sen ,   Professor, Hod, Department Of Medicine, Jorhat Medical College Hospital, Jorhat, Assam., Mainak Roy ,   Associate Proffesor , Department Of Biochemistry, Jorhat Medical College Hospital, Jorhat , Assam.
Published: June 2022

Background:Stroke is characterized by acute onset of focal neurological deficit lasting 24 hours or longer. With the increasing incidence of hemorrhagic stroke in Indians, the use of biochemical markers like Ferritin can predict outcome. This study was undertaken to study level of Serum Ferritin levels in patients with acute hemorrhagic stroke and it association with the outcome. Materials and Methods: This was a hospital based cross sectional observational study with 90 patients with acute hemorrhagic stroke admitted into the Department of Medicine, JMCH since 1st July 2020 till June 30th 2021. All the patients subjected to investigations and inclusion and exclusion criteria. Equal number of age and sex matched healthy individuals were included in the study as control Results: In this study the mean age group with Acute Hemorrhagic Stroke was 63.3 +-7.2 years. Of the total cases 57 were males (63.3%) and 33 female (37.7%). Hypertension was the most common risk factor associated present in 67.8% patients which is 53.3. The most common site of bleed was the basal ganglia. The mean serum Ferritin value was 333.44 +92.12ng/ml in patients with acute hemorrhagic stroke .The serum ferritin values correlated with the hematoma volume and higher values were associated with increased mortality . Conclusion: In the study Serum Ferritin values were significantly higher 445.29+-97.70 ng/ml (p value<.001) in patients which deteriorated and showed a positive correlation.
Miras Dil Kavramı ve Miras Dil Konuşucuları [The Concept of Heritage Language and Heritage Language Speakers]
Authors: SEN Yusuf
Published: June 2022

Bu makalenin amacı son yıllarda geniş bir coğrafyada akademik bir çalışma çalışma alanı olarak ta ortaya çıkan miras dil kavramının önemini ve bu alandaki çalışmaların miras dil alanında gösterilen çabaları destekleme konusunda sunduğu imkanları incelemektir. Miras dil kavramı, Kanada’da uzun yıllar sadece yerli halk dillerini ifade etmek için kullanıldıktan sonra, son yıllarda daha yaygın ve daha kapsayıcı olarak yerli halk dillerinin yanı sıra baskın bir dilin yanında varlığını sürdürmek durumunda olan bütün diller için kullanılmaya başlanmıştır. Bu geniş tanım ile miras dil grubunu oluşturan en büyük dil grubu göç veya iltica sonucu baskın dillerin yanında yaşamak durumunda kalan miras diller olmuştur. Günümüzde büyük ölçüde yerli, göçmen veya mülteci halkların dilleri ile ilgili eğitim-öğretim çabaları ve dilbilimsel çalışmalar, Uygulamalı Dilbilim alanı içinde yeni bir disiplinlerarası alan olarak ortaya çıkmakta olan miras dil ve miras dil konuşucuları başlıkları altında çalışılmakta ve tartışılmaktadır. Bu alanda son yıllarda yoğun olarak ortaya konan çalışmalar ve bilgi birikimi miras diller açısından oldukça zengin olan Türkiye’de miras dillerin farklı kurumlarda öğretimi, yok olma tehlikesi ile karşı karşıya olan birçok miras dilin tekrar canlılık kazanması çabalarını ve miras dillerin ve bu dilleri konuşanların dilbilimsel olarak incelenmesi çalışmalarını destekleyecek imkanlar sunmaktadır.
La herencia afín y las familias ensambladas: un análisis desde la perspectiva constitucional peruana
Authors: Del Valle Vargas Jorge Enrique Junior
Published: June 2022

La familia es una de las instituciones más básicas de la sociedad, que ha evolucionado a lo largo de los años, dejando atrás los conceptos tradicionales que la inspiraban. Ello ha permitido, por ejemplo, el reconocimiento de las estirpes ensambladas en nuestro ordenamiento jurídico. El Tribunal Constitucional del Perú les ha afirmado a los integrantes de estos linajes una serie de derechos y deberes en vida, al amparo del derecho a igualdad y no discriminación. Sin embargo, omite pronunciarse en lo que se refiere al derecho a la herencia. Nos proponemos analizar si sus razonamientos hasta el momento son idóneos, desde una perspectiva constitucional e internacional, para extender su protección a los derechos patrimoniales del plano inter vivos al mortis causa y así suplir el vacío normativo existente en lo que se refiere a la institución materia de esta investigación; concretamente, en el ámbito hereditario en la relación padre-hijo afín.
A mathematical approach to evaluate the extent of groundwater contamination using polynomial approximation
Authors: Agrawal Purushottam , Sinha Alok , Pasupuleti Srinivas , Sinha Jitendra , Chatterjee Ayan , Kumar Satish
Published: June 2022

Groundwater is being contaminated rapidly due to various anthropogenic activities and geogenic sources. In this direction, assessment of water quality analysis is the basic requirement for nurturing the human being and its evolution. The Water Quality Index (WQI) parameter has been widely used in determining water quality globally. The study aims to provide the suitability of groundwater in the specified region using the polynomial approximation method for drinking and irrigation purposes along with the computation of WQI using the conventional method. Weierstrass's polynomial approximation theorem along with longitudinal and latitudinal values has been used to evaluate the polynomial regarding various physicochemical parameters. To validate the obtained results from the present approach, groundwater quality data collected and analyzed from the Pindrawan tank area in Raipur district, Chhattisgarh, India, have been used. The result is obtained, i.e., the intermediate value of the parameters obtained correctly from the mathematical modeling, with an average error of 7%. This polynomial approximation method can also be used as the substitute of inverse modeling to determine the location of the source in the two-dimensional system. The approach output can be beneficial to administrators in making decisions on groundwater quality and gaining insight into the tradeoff between system benefit and environmental requirement.
Effects of pharmaceuticals compounds and calcium on granulation, microbiology, and performance of anaerobic granular sludge systems
Authors: Faria Clara V. , Costa Flávia C. R. , Jorge Alexandre E. L. , Melo Ana Luísa P. , Silva Ubiana. C. M. , Santos Vera L. , Amaral Míriam C. S. , Fonseca Fabiana V.
Published: June 2022

Granular sludge is a promising biotechnology to treat sewage contaminated with pharmaceuticals due to its increased toxicity resistance. In this context, this study evaluated the potential of Ca2+ as a granulation precursor and how pharmaceutical compounds (loratadine, prednisone, fluconazole, fenofibrate, betamethasone, 17α-ethinyl estradiol, and ketoprofen) affect granulation. Continuous and intermittent dosages of Ca2+ in the presence and absence of pharmaceuticals were evaluated. The results showed that intermittent addition of Ca2+ reduces the time for anaerobic sludge granulation, and pharmaceuticals presence did not impair granulation. 10% of the granules presented mean diameters greater than 2.11 mm within 93 days with intermittent Ca2+ dosage in the pharmaceuticals’ presence. In contrast, no granules higher than 2.0 mm were observed with no precursor addition. The pharmaceuticals' toxicity may have created a stress condition for the microbial community, contributing to more EPS production and a greater potential for granulation. It was also verified that pharmaceuticals’ presence did not decrease organic matter, total alkalinity, and volatile fatty acids removals. The 16S rRNA gene analysis revealed taxa resistance to recalcitrant compounds when pharmaceuticals were added. Besides, the efficiency of a granular sludge bioreactor (EGSB) was evaluated for pharmaceuticals removal, and betamethasone, fenofibrate, and prednisone were effectively removed.
Comparison of simple models for total nitrogen removal from agricultural runoff in FWS wetlands
Authors: Canet-Martí Alba , Grüner Sabrina , Lavrnić Stevo , Toscano Attilio , Streck Thilo , Langergraber Guenter
Published: June 2022

Free water surface (FWS) wetlands can be used to treat agricultural runoff, thereby reducing diffuse pollution. However, as these are highly dynamic systems, their design is still challenging. Complex models tend to require detailed information for calibration, which can only be obtained when the wetland is constructed. Hence simplified models are widely used for FWS wetlands design. The limitations of these models in full-scale FWS wetlands is that these systems often cope with stochastic events with different input concentrations. In our study, we compared different simple transport and degradation models for total nitrogen under steady- and unsteady-state conditions using information collected from a tracer experiment and data from two precipitation events from a full-scale FWS wetland. The tanks-in-series model proved to be robust for simulating solute transport, and the first-order degradation model with non-zero background concentration performed best for total nitrogen concentrations. However, the optimal background concentration changed from event to event. Thus, to use the model as a design tool, it is advisable to include an upper and lower background concentration to determine a range of wetland performance under different events. Models under steady- and unsteady-state conditions with simulated data showed good performance, demonstrating their potential for wetland design.
Produção do cuidado de enfermagem à saúde de homens em privação de liberdade: discurso coletivo
Authors: Batista da Silva Naomy Safira , Reis de Sousa Anderson , Rocha de Souza Kelane Borges , Alves de Oliveira Josias , Pereira Álvaro
Published: June 2022

Objetivo: Conhecer, através do discurso de profissionais de Enfermagem, como se dá o cuidado prestado à saúde de homens em privação de liberdade no sistema prisional. Métodos: Trata-se de um estudo de campo, qualitativo, descritivo e exploratório desenvolvido no Conjunto Penal de Feira de Santana - Bahia. A coleta de dados foi realizada por meio da entrevista semiestruturada com 5 profissionais e a análise do conteúdo se deu pela técnica do Discurso do Sujeito Coletivo. Resultados: Foi evidenciada uma prática de cuidado norteada pelo modelo biomédico, com perspectivas idealísticas de mudança. Conclusão: O conhecimento técnico e científico, a consciência da relevância do papel do profissional de enfermagem e a sensibilidade aos ajustes para promover saúde na penitenciária são itens necessários para uma prestação do cuidado de Enfermagem adequada.Descritores: Enfermagem; Saúde do homem; Prisões.PRODUCTION OF NURSING CARE TO MEN’S HEALTH IN DEPRIVATION OF LIBERTY: COLLECTIVE DISCOURSEObjective: To know, through the discourse of nursing professionals, how the health care of men in deprivation of liberty in the prison system. Methods: This is a field study, qualitative, description and explorer developed in a Conjunto Penal de Feira de Santana - Bahia. The data collection was performed through semi-structured interviews with 5 professionals and content analysis was performed using the Collective Subject Discourse technique. Results: An assistance practice based on the biomedical model was evidenced, with ideal prospects for change. Conclusion: Technical and scientific knowledge, awareness of the importance of the nursing professional’s role and sensitivity to adjustments to promote health in the penitentiary are necessary items for the provision of adequate nursing care.Descriptors: Nursing; Men’s health; Prisons.PRODUCCIÓN DE CUIDADOS DE ENFERMERÍA PARA LA SALUD DEL HOMBRES PRIVADOS DE LIBERTAD: DISCURSO COLECTIVOObjetivo: Aprender, a través del discurso de los profesionales de enfermería, cómo se brinda atención médica a los hombres privados de libertad en el sistema penitenciario. Métodos: Estudio de campo cualitativo, descriptivo y exploratorio, desarrollado en el Conjunto Penal de Feira de Santana - Bahia. La recolección de datos se realizó a través de entrevistas semiestructuradas com 5 professionales y análisis de contenido, utilizando la técnica del Discurso colectivo del sujeto. Resultados: Se evidenció una práctica asistencial basada en el modelo biomédico, con perspectivas idealistas de cambio. Conclusión: El conocimiento técnico y científico, el conocimiento de la relevancia del papel del profesional de enfermería y la sensibilidad a los ajustes para promover la salud en el centro penitenciario son elementos necesarios para la provisión de cuidados de enfermería adecuados.Descriptores: Enfermería; Salud del hombre; Prisiones.
Yükseköğretim Kurumlarında Gerçekleştirilen Buluşlar
Authors: Aydın Sema
Published: June 2022

Sınai Mülkiyet Kanunu ile yükseköğretim kurumlarında mevcut buluş potansiyelinin ortaya çıkarılması ve ekonomiye kazandırılması için bilimsel araştırma ve çalışmalar sonucu ortaya çıkan buluşlar üzerinde yükseköğretim kurumuna hak sahipliği talebinde bulunma imkanı verilmiştir. Buluş potansiyeli en yüksek kurumlardan biri olan yükseköğretim kurumlarında hak sahipliği konusunun çözümü, buluş sahibi ve yükseköğretim kurumu açısından önemlidir. Mevcut buluşların patent sürecine dahil edilmesi ve ticarileştirilmesi ile ülke ekonomisi ve toplum yarar sağlar. Patent hakkının korunması, ülke içinde ekonomik büyümeyi beraberinde getirerek, teknoloji üretimi ile transferine uygun zemin hazırlar. Yükseköğretim kurumlarında gerçekleştirilen buluş üzerinde hak sahipliğinin belirlenmesi, başvuru ve bildirim yükümlülüğü, hak sahipliği kararına itiraz, hakkın devri ve buluştan elde edilecek gelirin paylaşımı Sınai Mülkiyet Kanunu ve Çalışan Buluşlarına, Yükseköğretim Kurumlarında Gerçekleştirilen Buluşlara ve Kamu Destekli Projelerde Ortaya Çıkan Buluşlara Dair Yönetmelik çerçevesinde incelenecektir.
Antitumor Inhibitors of DNA Topoisomerases
Authors: Capranico G. , Zunino F.
Published: June 2022

DNA topoisomerases are nuclear enzymes that regulate DNA topology during transcription , replication and recombination processes, and are essential for the integrity of the genetic material. Eukaryotic DNA topoisomerases are the cellular targets of important antitumor drugs, such as intercalating agents, minor-groove binders and others. These agents interfere with topoisomerases by forming ternary DNA-drug-enzyme complexes in which DNA strands are broken and protein-linked. Topoisome-rase can be diveded into two mechanistic classes: type I and type II DNA enzymes. One type I, and two type II topoisomerases are present in human cells. The expression of the two human topoisomerase II isozymes, encoded by two distinct genes, are differentially modulated during cell proliferation and development. In recent years, x-ray diffraction studies as well as molecular and analyses have allowed to progress in the understanding of the structure and function of DNA topoisomerases. Drug structural genetic determinants have been partially elucidated by studing the DNA sequence specificity of drug stimulation of topoisomerase II DNA cleavage and by novel structure-activity relationship studies, thus eventually allowing the design of new agents targeted at selected genomic regions. Moreover, recent investigations on topoisomerase II inhibitors that do not stimulate DNA cleavage demonstrated that these agents may act against topoisomeras with a novel mechanism, thus suggesting new screening strategies to identify potential antitumor drugs. The initial cellular lesion, i.e. the drug-stabilised cleavable complex, is a reversible molecular event, however how it can lead to cell death remains to be fully understood. Irreversible double-stranded DNA breaks, generating from collisions between cleavable complexes and ongoing DNA-dependent processes may be the trigger of the cell death programme. This review will summarize and discuss recent advances in the molecular pharmacology of antitumor topoisomerase inhibitors.
Effects of Anthracyclines on Cellular Differentiation and Oncogene Expression: Implications for Carcinogenesis and Cancer Chemotherapy
Authors: Schaefer A. , Steinheider G. , Stocker U. , Marquarctt H.
Published: June 2022

Regulation of cellular differentiation has been suggested to play a major role in the mechanisms of chemical carcinogenesis as well as in the therapeutic effects of anticancer drugs . Therefore , the establishment of differentiation assays appears important in oncology research . Leukemic cell lines have been used as experimental models to study the differentiation-inducing effect of cytostatic compounds in neoplastic cells . Experiments with anthracycline antibiotics in Friend erythroleukemia cells and HL-60 cells showed 1] a structure-specific induction of differentiation and 2] an early differentiation-specific down-regulation of c-myc and c-myb mRNA levels. These results
suggest that the induction of differeniation by anthracyclines occurs through specific biochemical mechanisms and that increased
cell maturation is not based on a general suppression of cell proliferation. Therefore, the specific induction of differentiation in
certain leukemic cells may be a therapeutic advantage of differentiation -inducing anthracyclines such as aclacinomycin A and
related compounds.
DNA Minor-Groove Binding Drugs
Authors: Zunino F. , Animati F. , Capranico G.
Published: June 2022

Since neoplastic transformation is likely related to oncogene activation or alterations in specific genes, there is much interest in the development of drugs capable of specific gene inactivation. In particular, DNA minor-groove binding drugs have been extensively studied to determine their ability to influence the regulation of gene expression. Sequence-selective groove binders have been designed · as carriers of alkylating moieties. Prototypical agents of this class are alkylating derivatives of distamycin. These compounds exhibit a markedly enhanced cytotoxicity over conventional benzoyl N­ mustards and a significant antitumor activity in preclinical evaluation . Cyclopropylpyrroloindole analogs
are very potent antitumor agents which interact with minor-groove DNA favoring an alkylation reaction in a sequence-selective
manner. In addition, a number of DNA-damaging cytotoxic agents or DNA topoisomerase inhibitors are known to contain minor­
groove binding elements. The identification of. drug structural factors that have a role in promoting DNA recognition during formatiOn of DNA cleavage or covalent modificatwn represents a basis for a rational design of more specific inhibitors. The antitumor efficacy in preclinical evaluation and early clinical studies of sequence-specific minor-groove alkylators is described.
Satisfaction with Social Roles and Physical Function in Immune-mediated
Inflammatory Diseases: A Cross-Sectional Study
Authors: Spagnuolo Rocco , Iaquinta Francesco Salvatore , Mauro Daniele , Pantano Ilenia , Dastoli Stefano , Naty Saverio , Cosco Cristina , Mancina Rosellina Margherita , Iacono Daniela , Gaggiano Emanuela , Ruggiero Annarita , Nisticò Steven Paul , Ciccia Francesco , Grembiale Rosa Daniela , Patrizia Doldo
Published: June 2022

Background:

Although mood disorders have been well characterized by immune-mediated inflammatory diseases, physical function and satisfaction with social roles have not yet been defined as independent domains.

Objective:

The study aims to assess satisfaction with social roles and physical function alterations in a population with immune-mediated inflammatory diseases and identify associated characteris-tics.

Methods:

Physical function and social role satisfaction were evaluated through the Patient-reported Outcomes Measurement System. Besides comparison between groups, univariate and multivariable logistic regression analyses were performed to identify independent predictors.

Results:

Two hundred sixty-five patients with immune-mediated inflammatory diseases and 206 controls were recruited. Compared to controls, patients with inflammatory bowel diseases had impaired physical function (p<0.001), while patients with inflammatory arthritis reported impair-ment in both domains (p<0.001, each). In the univariate logistic regression, gender, high school educational level, physical activity, and occupation were positively associated with physical func-tion and social role satisfaction (p<0.001; p=0.001; p<0.001; p=0.001 and p<0.001; p=0.012; p=0.008; p=0.004, respectively). Active disease and steroids were inversely associated with phys-ical function and social roles satisfaction (p=0.033; p=0.022 and p=0.002; p=0.038, respectively). Further associations were found between age and physical function (p=0.002) and biological treatment and ESR with social roles satisfaction (p<0.001; p=0.043; respectively). In the multivar-iable regression, gender was found to be associated with physical function (p<0.001) and social roles satisfaction (p=0.003). Negatively associated factors were biological treatment for satisfac-tion with social roles (p<0.001) and steroids for physical function (p=0.021), and social roles sat-isfaction (p=0.018).

Conclusion:

Immune-mediated inflammatory diseases determine alterations in physical function and social life satisfaction. Gender and treatment are independently associated factors. Patient-reported outcomes should be considered in clinical management to define patients’ real needs.
Role of DPP4 and DPP4i in Glucose Homeostasis and Cardiorenal Syndrome
Authors: Panda Siva Prasad
Published: June 2022

The objective of the review led to the pursuit of adopting dipeptidyl peptidase-4 inhibitors
(DPP4i) as a novel pharmacotherapy in diabetes mellitus (DM) and cardiorenal syndrome
(CRS). The CRS is defined as the co-existence of myocardial ischemia with renal failure. At present,
the commercially available drugs enhance insulin secretion or action. However, most of the
drugs are associated with adverse effects, such as weight gain or hypoglycemia. As a result, newer
therapies with better safety and efficacy profiles are being explored. The DPP4 protease enzyme
is involved in cardiovascular and renal diseases in association with over-expressed cytokines. The
novel characteristic of DPP4i is to control the elevated blood glucose levels in response to nutrient
ingestion without causing hypoglycemia. Also, DPP4i are indirectly involved in reducing myocardial
ischemia by promoting cardioprotective peptides. They protect the glucagon-like peptide 1
(GLP-1) from the deteriorating effect of the DPP4 enzyme. The GLP-1 receptors (GLP-1R) are
abundantly expressed in renal and cardiovascular tissue. The overexpression of GLP-1R will confer
protection of the heart and kidney during CRS. DPP4i were found to significantly clear plasma
glucose by the simultaneously activating natural thrombolytic system and increasing insulin levels.
They can be used in the early stages of the disease, including pre-diabetes or obesity combined
with impaired incretin response, while the combination of DPP4i with metformin or thiazolidinediones
as insulin sensitizers offers an additional improvement in the treatment of DM. With its positive
attributes in a host of associated parameters of interest, DPP4i are studied extensively in the
present review.
The Effect of Ramp Proximity, Weather, and Time-of-Day on Freeway Accident Frequency: A Case Study on I-75 and I-24 in Hamilton County, TN
Authors: Laflamme Eric M. , Way Peter , Roland Jeremiah , Sartipi Mina
Published: June 2022

Background:

We present a case study to quantify the dangers of freeway ramps by comparing the observed accident counts from ramp locations to those from adjacent mainline locations. Few works make this direct comparison. Additionally, time-of-day and weather information is considered to collect a deeper understanding of the nature of freeway accidents near ramps. Real-world data collected from freeways in Hamilton County, TN, are considered as an application and give interesting results.

Methods:

First, we precisely define ramp influence areas or areas within close proximity to ramp locations where traffic is suspected to be affected by the ramp structure/geometry. Then, we introduce a theoretically justified Negative Binomial regression model to approximate the relationship between accident counts (response), presence of ramp influence areas, and additional weather and time-of-day designations. Our model also considers selected interaction terms, route designation, and multiple random components that are aimed at explaining unmeasured sources of variation.

Results:

Based on the interpretation of our fitted statistical model, we find that being in an influence/ramp area (compared to being in mainline traffic), on average, results in a 4-fold increase in accident frequency. Moreover, we find that during clear conditions, rush hour conditions increase the accident frequency substantially, while during rainy conditions, this increase is much less stark. During non-rush hour conditions, rain decreases the accident frequency substantially, and during rush hours, this decrease is intensified. Model diagnostics and a validation procedure further justify the assumed model form and lend credence to our results.

Conclusion:

While we do not make any claim of transferability of our results, they provide a proof-of-concept that accident frequency is attributable to multiple factors, among which is proximity to ramps. Furthermore, our procedure and statistical model allow us to directly quantify how these factors, most notably ramp traffic, effect accident frequency. These results illuminate potential safety risks. Subsequent work considering more diverse roadways could provide the evidence needed for policy changes and/or remedial measures.
Application of Plant Extracts for the Synthesis of Nanoparticles in Green
Chemistry: A Concise Update
Authors: Chakraborty Prithviraj , Khatiwara Bunu , Singh Simran , Sarangi Samarpan , Das Arnab , Dhakal Jigyasha
Published: June 2022

Green synthesis of nanoparticles is an emerging topic with many significant applications in environmental and biomedical fields. The main aim of green synthesis is the development of eco-friendly nanoparticles using biological materials like plants and microbes and thus, reducing the practice of utilizing toxic substances. Different plant-derived materials are regularly utilized to synthesise sustainable nanoparticles with almost comparable properties yet utilize less hazardous manufacturing processes. This review aims to update these green synthetic processes for developing nanoparticles.
Artificial Intelligence-Enabled Model for Predicting the Metastatic Potential of Cancer Cells
Authors: Acharya Sarbari , Mohanty Chandana
Published: June 2022

Cancer is a deadly and aggressive disease with an abominably low median
survival rate. Treatment of the disease is an economic burden long owing to its high
recurrence and mortality rates. Metastasis of cancer is one of the reasons for treatment
failures, as these metastatic cells are resistant to all types of conventional treatments.
Thus early and accurate diagnosis of metastasis is essential to design the course of the
treatment regime. Evolutions in statistics and computer engineering over the past
decade have encouraged researchers to implement computational methods to analyze
the stage and advancement of the disease with precision and accuracy. Furthermore,
artificial intelligence (AI), especially machine learning and deep learning, has been
implicitly used in medical sectors, including clinical cancer research, in recent years.
This article reviews the application of AI to detect cancer metastasis and
comprehensively summarizes its advantages.
Far-right populism in Canada
Authors: Balgord Evan
Published: June 2022

On March 17, 2022, Mr. Evan Balgord, Executive Director of the Canadian Anti-Hate Network, presented Far-Right Populism in Canada: From M103 to the Ottawa Occupation at the March Digital Roundtable event, hosted by the Canadian Association for Security and Intelligence Studies (CASIS)-Vancouver. The key points of discussion included the connections between different far-right movements in Canada and how grievances and beliefs on conspiracy theories can serve as the groundwork for radicalization and participation in far-right movements. Mr. Balgord’s presentation was followed by a question-and-answer period with questions from the audience and CASIS-Vancouver executives.
Health security, environmental security, and hard security in the Arctic
Authors: Huebert Robert
Published: June 2022

On February 17, 2022, the Canadian Association for Security and Intelligence Studies (CASIS)-Vancouver hosted a digital roundtable titled Health Security, Environmental Security, and Hard Security in the Arctic: A Complex Relationship, conducted by Dr. Rob Huebert, a research fellow for the Center for Military, Security and Strategic Studies and an associate professor at the University of Calgary. The presentation was followed by a question-and-answer period with questions from the audience and CASIS-Vancouver executives. The main discussion topics centered around health, the environment, geopolitics, and hard power in the Arctic.
Domestic Russian politics and comparative democratization
Authors: Sundstrom Lisa
Published: June 2022

On April 21, 2022, Dr. Lisa Sundstrom, an expert on Russian politics and a professor of Political Science at the University of British Columbia (UBC), presented Domestic Russian Politics and Comparative Democratization at the April Digital Roundtable event hosted by the Canadian Association for Security and Intelligence Studies (CASIS)-Vancouver. The key points of discussion included the popularity of the war in Russia, the economic impacts of sanctions and military losses, and the potential sources of opposition to President Vladimir Putin. Dr. Sundstrom’s presentation was followed by a question-and-answer period with questions from the audience and CASIS-Vancouver executives.
Clinical relevance of natural killer cells in breast cancer
Authors: Gulić Tamara , Blagojević Zagorac Gordana , Veljković Vujaklija Danijela , Valković Zujić Petra , Avirović Manuela , Starčević Alma , Grebić Damir
Published: June 2022

Breast carcinoma is the most common malignant disease in the female and one of the leading causes of death among women worldwide. Chronic inflammation and immunosuppressive environment achieved by the interaction of tumour and infiltrating immune cells are the hallmarks of cancers, including breast cancer. Natural killer cells are one of innate immune cells in tumour bed that possess great antitumour potential due to their ability to kill tumour cells without prior sensitization. They also play an important role in priming of type I immune responses and are considered to be main source of Interferon-γ. Unfortunately, antitumour activity of natural killer cells is often suppressed by pro-inflammatory cytokines secreted in tumour microenvironment and suppression of NK cells activity often correlates with therapy response and general outcome of patient with breast carcinoma. Different types of breast cancer are associated with different subsets of natural killer cells that possess different immunoregulatory function. Identification of specific tumour associated natural killer cell subset endowed with different functional capabilities might help practitioners in therapy decisions, therapy response monitoring, as well as in predicting overall prognosis of breast cancer patients. The purpose of this review is to give an overview of natural killer cells and their subsets, their role in pathogenesis of breast cancer and to discuss NK cells as potential useful therapy and prognostic tool for breast carcinomas.