bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlation between Microvessel Density Based on CD31 Immunohistochemical Expression and Clinicopathology of Invasive Breast Carcinoma
Authors: Bitaria Febrawati Eka , Alferraly T. Ibnu , Betty Betty
Published: September 2023

Background

Breast carcinoma is the most common malignancy in women worldwide. Tumor size, metastases, lymph node involvement (KGB), stage and histopathological grade are significant prognostic factors in invasive breast carcinoma. Microvessel density (MVD) assessment is used to measure angiogenesis which helps predict tumor behavior and the effect of antiangiogenic therapy. MVD is a quantitative calculation of intratumoral capillary blood vessels which reflects the results of the process of angiogenesis. The aim of this study was to analyze the relationship between MVD based on CD31 immunohistochemical expression and the clinicopathology of invasive breast carcinoma.

 

Method

Cross sectional analytic study with 42 samples diagnosed with invasive breast carcinoma at H. Adam Malik General Hospital Medan. MVD is the number of small blood vessels in terms of size and diameter (arterioles and venules) with a round lumen that is positively stained with CD31 at 10 large visual fields, categorized as low if <45 blood vessels/10 LPB and high if ≥45 blood vessels/10 LPB. The relationship between MVD and several clinicopathological parameters was analyzed using the Chi-Square, Fisher's Exact and Mann-Whitney tests.

 

Results

There was a significant relationship between tumor size (p=0.029), metastasis (p=0.014), stage (p=0.002), histopathological grade (p=0.0043), LVI (p=0.002), TILs (p=0.007). Large tumor size, metastases, high histopathological stage and grade, positive LVI and high TILs were significantly associated with MVD. However, there was no significant relationship between KGB involvement (p=0.570) and MVD.

 

Conclusion

MVD is significantly related to tumor size, metastases, stage, histopathological grade, LVI and TILs, and not significantly related to lymph node involvement. MVD plays a role in the angiogenesis of invasive breast carcinoma clinicopathology.
The Association of Fibulin-2 Expression with Histopathological Grade and Fibrotic Tumor Vessel in Meningioma
Authors: Kamelia Muthia , Agus Salmiah , Tofrizal Tofrizal
Published: September 2023

Background

Meningiomas are the most common primary tumors of the central nervous system. About one-fifth of meningiomas tend to recur. The World Health Organization (WHO) histopathological grade was the most useful morphological predictor of recurrence. Fibrotic tumor vessels (FTV) were detected in nearly half of WHO grade I meningiomas and correlated with vascular density and increased risk of recurrence. Fibulin-2 is an extracellular matrix glycoprotein whose expression increases in traumatic central nervous system injuries and can be used as a marker to differentiate the histopathological grade of meningiomas. This study aimed to determine the association of fibulin-2 expression with histopathological grade and FTV in meningiomas.

 

Methods

This research was an observational cross-sectional study. The study sample was 36 cases of meningioma in three Anatomical Pathology laboratories in West Sumatra on period January 2019 to December 2020. Samples obtained from resected meningioma cases were then reevaluated on Hematoxylin Eosin (HE) slides to determine the histopathological grade and FTV. Van-Gieson staining was performed to confirm FTV. Fibulin-2 expression in tumor cells was analyzed using immunohistochemical staining. Bivariate statistical analysis using the Chi-Square test with p<0.05 was considered significant.

 

Result

High-risk meningiomas (WHO grade II and III) showed high fibulin-2 expression (62.5%), whereas low-risk meningiomas (WHO grade I) were more abundant with low fibulin-2 expression (75%). The presence of FTV at low fibulin-2 expression was 58.3%. Statistical analysis showed no significant association between fibulin-2 expression with histopathological grade (p=0.077) and FTV (p=1,000).

 

Conclusion

In summary, the study showed that fibulin-2 expression was not associated to histopathological grade nor to FTV in meningiomas.
What the HALM Is This?
Authors: Angood Peter , Weiss Kevin , White Suzanne , Hawkins Richard
Published: September 2023

A panel at the American Association for Physician Leadership (AAPL) Annual Conference, June 9, 2023, was dedicated to a discussion of the initiative surrounding the new Healthcare Administration, Leadership, and Management (HALM) credential. Moderated by Peter Angood, MD, he was joined by Kevin B. Weiss, MD, MPH, Suzanne R. White, MD, MBA, and Richard E. Hawkins, MD. This article is a transcript of the panel discussion.
The Impact of Medicaid Expansion on Critical Access Hospitals: A Game-Changer for Healthcare Accessibility
Authors: Welch Baynes
Published: September 2023

Medicaid expansion has undeniably brought about a positive transformation in the landscape of healthcare accessibility, particularly for CAHs in states that have adopted this expansion. The increase in Medicaid funding resulting from higher, insured patient volumes has allowed CAHs to become more financially stable, invest in modern infrastructure and medical technology, and expand their scope of services. By continuing to expand Medicaid and invest in CAHs, the nation can ensure that healthcare remains accessible and affordable for all, particularly in underserved rural communities.
Games People and Physicians Play: Gamification of Medical Education
Authors: Gantwerker Eric , Baum Neil
Published: September 2023

Video games have existed for decades as a source of entertainment but have now found themselves at the center of the rejuvenation of digital resources for healthcare professionals and organizations. Healthcare-related games and their adjunctive technologies (including virtual reality) are poised to provide great educational resources for doctors, nurses, and allied health professionals as well as patients and families. This article discusses video games as educational tools for the medical profession.
Remuneração de professores e resultados: há correlações?
Authors: Andrade Clériston José da Silva , Santos Paulo César Marques de Andrade , Ferreira Rosilda Arruda
Published: September 2023

O artigo aborda, a partir de pesquisa documental e bibliográfica, a possível correlação entre remuneração dos professores e resultados educacionais, utilizando, para efeitos comparativos, os municípios no âmbito da Região Administrativa Integrada de Desenvolvimento do Polo Petrolina e Juazeiro. Trata-se de uma problemática relevante, uma vez que a valorização docente é uma demanda histórica e que esta suposta correlação é frequentemente discutida por setores da sociedade. Conforme evidenciado, não obstante os avanços já conquistados, os professores ainda convivem com baixos salários, excesso de carga horária, condições de trabalho insuficientes, entre outras dificuldades. Nesse sentido, no que se refere à remuneração, tem sido possível assistir a tentativas de relacionar um melhor pagamento aos professores com um resultado educacional satisfatório, o que nem sempre se confirma na prática. No caso específico da região estudada, os levantamentos permitiram concluir que não se sustenta, efetivamente, uma correlação entre a remuneração dos professores e os resultados educacionais obtidos nas escolas. O texto observa que, embora salários mais atrativos possam motivar os docentes, outros fatores se mostram igualmente relevantes para explicar os resultados obtidos. Desse modo, conclui-se que outras ações precisam ser adotadas pelos gestores públicos e dirigentes de educação para obterem-se resultados satisfatórios. Ademais, há a defesa da efetivação dos objetivos propostos para a RIDE do Polo Petrolina e Juazeiro quando de sua criação, visando à promoção de avanços sociais e econômicos em todos os municípios da região, inclusive na educação básica.
Avaliação do índice de qualidade da água superficial na zona rural e urbana de município no noroeste do Rio Grande do Sul
Authors: Bobato Daniela Schmitt , Bisognin Ramiro Pereira , Guerra Divanilde , Lanzanova Mastrângello Enivar , Weiss Daiane , Maciel Diego Hider , Rossini Tuisi , Bobato Gabriela Schmitt
Published: September 2023

A água é indispensável às diferentes formas de vida e às atividades humanas, por isso o monitoramento de sua qualidade é necessário para a melhor gestão dos recursos hídricos. Nesse sentido, objetivou-se com este estudo avaliar a qualidade da água superficial em diferentes pontos de um município no Noroeste do Rio Grande do Sul. As coletas de água foram realizadas em seis pontos distintos, três distribuídos na área rural e outros três na área urbana. Foram executadas duas campanhas de coleta de água, no mesmo ano, sendo a primeira realizada no mês de janeiro e a segunda no mês de março de 2023. Em cada campanha amostral avaliou-se os nove parâmetros para determinação do Índice de Qualidade da Água (IQA), e com base na concentração de fósforo total realizou-se o Índice de Estado Trófico (IET). No momento da coleta também se realizou a análise das condições das áreas de preservação permanente (APP) no entorno dos pontos de amostragem. Como resultados, foi possível verificar a interferência das atividades do meio urbano nos cursos hídricos, uma vez que os pontos localizados nesse meio obtiveram os piores resultados, com predominância de IQA “ruim” em relação aos pontos amostrados no meio rural, onde predominou o índice de qualidade da água “aceitável”. Quanto ao IET, observou-se que 67% dos pontos em meio rural apresentaram estado trófico ultraoligotrófico e 33% oligotrófico, este último por influência do meio urbano, no qual os pontos variaram de ultraoligotrófico, oligotrófico e mesotrófico. Muitos desses resultados de degradação da qualidade da água são potencializados devido as condições inadequadas de conservação das APPs e/ou inexistência da faixa mínima exigida por legislação. Diante desses resultados, é premente a necessidade de ações para melhoria da qualidade das águas, principalmente no meio urbano.
Distribuição de probabilidades para determinação de vazão mínima de referência anual e sazonal da bacia do Rio Araranguá, Santa Catarina, Brasil
Authors: Galatto Sérgio Luciano , Back Álvaro José
Published: September 2023

A determinação de vazões mínimas de referência anual e sazonal contribui para a melhor alocação da água, minimizando conflitos de uso, e possibilitando definir limites outorgáveis baseados em critérios de risco. Este trabalho objetivou analisar a aplicação das funções de distribuição de probabilidade Weibull (dois e três parâmetros), Gumbel, Log-Normal com dois e com três parâmetros, Pearson Tipo III e Log-Pearson Tipo III às séries históricas de vazões mínimas diárias anuais e sazonais de sete dias consecutivos para seis estações fluviométricas na bacia do rio Araranguá. Foram usados o Método de Momentos, da Máxima Verossimilhança e dos L-Momentos. A aderência dos dados foi analisada usando os testes de Kolmogorov-Smirnov e Anderson-Darling. A seleção da distribuição foi realizada baseada nos índices de desempenho do erro padrão de estimativa, erro absoluto médio e no D-index. Os resultados indicaram que a distribuição Weibull (dois e três parâmetros) demonstra maior precisão na representação dos dados anuais entre as seis estações fluviométricas. Por outro lado, a análise em dados trimestrais, apontou a utilização da distribuição Log-Normal como a mais adequada para estimativa das vazões mínimas.
Cálculo diferencial e integral na formação de professores: fragmentos possíveis
Authors: Beltrão Isabel do Socorro Lobato , Gomes Josias da Silva , Beltrão Marcus Vinícius Lobato , Serrão Maria do Carmo dos Santos , De Souza Joerlen Alves , Gomes Edilson Barroso
Published: September 2023

O presente trabalho, apresenta resultados de um estudo desenvolvido por meio do Programa de Apoio a Iniciação Científica – PAIC, cujo objetivo foi analisar as dificuldades dos acadêmicos da licenciatura em matemática na disciplina de Cálculo Diferencial e Integral I, que contém a disciplina em sua grade curricular no biênio 2020-2021. O estudo se torna importante, por ter buscado dirimir dificuldades de compreensão nessa disciplina, e, se torna relevante à medida em que buscou contribuir para a formação do acadêmico pesquisador, ampliando um leque de questões investigadas sobre esse mote das dificuldades dos acadêmicos do Centro de Estudos Superiores de Parintins. A pesquisa se caracteriza de natureza qualitativa, por se tratar de uma investigação que suscitou a compreensão de uma realidade investigada. Utilizou-se como instrumento de construção de dados, a análise documental, por meio da qual foram analisados documentos e planilhas de notas de Cálculo I, dos cursos de Licenciatura em Biologia, Física, Matemática e Química, no biênio 2020-2021. Realizou-se entrevistas semiestruturadas com acadêmicos desses cursos sobre as dificuldades pertinentes a Cálculo I. Os dados foram coletados e analisados à luz de teóricos como Pagani e Allevato (2014); Cury (2009); Rezende (2003); Rafael e Escher (2015) dentre outros, que nos ajudaram a responder o problema científico da pesquisa. Os resultados indicam múltiplos fragmentos que podem estar diretamente relacionados as dificuldades de aprendizagem em Cálculo I, entre os quais se destaca, a necessidade de incentivar frequência à monitoria e as aulas regulares e o precário conhecimento em Matemática Elementar. Também foi possível perceber dificuldades de aprendizagem ligadas à acadêmicos que estavam há muito tempo fora da escola, fatores que indicam a necessidade de implementação de metodologias atraentes aos estudos de Cálculo I, esses fatores podem acordar maior interesse dos alunos e quiçá diminuir o alto índice de reprovação nessa disciplina.
Ограниченность совокупности решений линейной однородной системы, равномерная по начальному отрезку
Authors: Марголина Наталия Львовна , Margolina Natal'ya L'vovna , Ширяев Кирилл Евгеньевич , Shiryaev Kirill Evgen'evich
Published: September 2023

Статья содержит определения некоторых свойств решений линейных систем обыкновенных дифференциальных уравнений и доказательство того факта, что эти свойства не одинаковы для неограниченных систем.
Обобщенные формулы Чезаро и уравнения совместности третьего порядка
Authors: Лурье Сергей Альбертович , Lur'e Sergei Al'bertovich , Белов Петр Анатольевич , Belov Petr Anatolevich
Published: September 2023

Рассматривается классическая проблема теории упругости об условиях совместности деформаций, обеспечивающих определение непрерывного поля перемещений упругого тела по полю деформаций. Построены обобщенные представления Чезаро, позволяющие с точностью до квадратичных полиномов определить поле перемещений через интегро-дифференциальные операторы от компонент тензора-девиатора деформаций. Установлено, что квадратуры и для псевдовектора локальных поворотов, и для деформации изменения объема полностью задаются полем девиатора деформаций. Представлены условия существования перечисленных квадратур, которые записываются в виде пяти уравнений совместности третьего дифференциального порядка относительно пяти компонент тензора-девиатора деформаций.
Орторекурсивное разложение по модификации системы Фабера-Шаудера
Authors: Степанянц Петр Суренович , Stepanyants Petr Surenovich , Паунов Александр Константинович , Paunov Alexander Konstantinovich
Published: September 2023

Рассмотрены орторекурсивные разложения по модификации системы Фабера-Шаудера. Доказана равномерная сходимость разложения к разлагаемой непрерывной функции. Также доказана сходимость разложения к разлагаемой функции в пространствах $L_p$.
Инварианты Жордана-Кронекера сингулярных пучков для шестимерных вещественных нильпотентных алгебр Ли
Authors: Лобзин Фeдор Игоревич , Lobzin Feodor Igorevich
Published: September 2023

Вычислены инварианты Жордана-Кронекера сингулярных пучков для шестимерных нильпотентных алгебр Ли.
A test experiment on determining the cluster structure of highly excited states of 6Li
Authors: Mordovskoy M.V. , Kasparov A.A. , Afonin A.A. , Zavarzina V.P. , Kurlovich A.S. , Mitcuk V.V. , Surkova I.V.
Published: September 2023

The paper presents the results of test measurements to determine the possibilities of studying the cluster
structure of highly excited states of the 6Li nucleus in the 6Li(𝑛, 3He 𝑛)
3H reaction on the RADEX neutron
channel of the Institute for Nuclear Research of the Russian Academy of Sciences. In the experiment, scattered
neutrons were detected in coincidence with the decay products of highly excited states (helium-3). The first
experimental data on the excitation energy of the 6Li nucleus have been obtained.
Spectral barcode based on one-dimensional photonic crystal with continuous refractive index modulation
Authors: Svyakhovskiy S.E. , Pyshkov N.I.
Published: September 2023

This paper demonstrates an example of optical information encoding using the spectral response of a photonic crystal. The spectral dependence of the reflection coefficient of a one-dimensional photonic crystal reproduces the sequence of the EAN-13 standard barcode. An algorithm for building the structure of a photonic crystal
based on a given encoded sequence of 12 digits was developed. This structure was experimentally implemented, its spectral response allows to decode the original encoded sequence.
Effect of fluorination on properties of thiophene-phenylene co-oligomers with annulated core: a DFT study
Authors: Korchkova S.N. , Sosorev A.Yu.
Published: September 2023

Organic light-emitting transistors are a new type of optoelectronic devices that combine the functionality of
OLED and a transistor that controls it. The working layer of these devices requires organic semiconductors
that combine high charge mobility with a high photoluminescence quantum yield. One of the promising classes
of such materials are thiophene-phenylene co-oligomers, the properties of which can be tuned over a wide range by adding various substituents. In this work, we address the effect of fluorination on the properties of
two model thiophene-phenylene co-oligomers with an annulated central fragment, P–TTA–P and P–BTBT–P.
It is shown that fluorination of both molecules lowers their frontier orbitals energy levels, and this should
enable electron transport in their crystals and films. At the same time, fluorination has a qualitatively different
effect on the delocalization of frontier orbitals, the width of the optical gap, the oscillator strength, the exciton
binding energy, and the Raman spectrum, which is explained by the difference in the equilibrium geometry
of fluorinated molecules. It is expected that the revealed relationships between the structure and properties
of the studied compounds will contribute to the rational design of organic semiconductors for efficient light
emitting devices.
Magnetic properties of iron oxide nanoparticles in the matrix of potassium-aluminoborate glasses subject to thermoradiation treatment
Authors: Salakhitdinova M. K. , Ibragimova E. M. , Kuvandikov O. K.
Published: September 2023

The paper presents the results of investigations of the magnetic properties of glasses of the composition
K2O · Al2O3 · B2O3 (KAB) with the addition of Fe2O3 2.0 and 3.0 wt.subjected to radiation treatment
in 60∘C gamma field at dose rate of 236 R/s for 2 hours at room temperature and when samples are
heated to 423 K. Both under radiation and thermoradiation exposure, the magnetic susceptibility of glasses
follows the Curie–Weiss law at 4.2–200 K and slightly deviates from this dependence at 200–340 K. The
weakly pronounced magnetic hysteresis with low coercive force was detected at low temperatures against the
background of magnetization that depends almost linearly on the field. An analysis of data on the temperature
and field dependences of magnetization in weak and strong fields, combined with data on structural and
optical properties, indicates that mainly Fe2O3 nanoparticles in the uncompensated antiferromagnetic state
are formed in glasses, as well as an insignificant amount of dissociated Fe and Fe3O4 ions.
Theoretical study of resonant charge exchange between H−ion and
adsorbate-covered metal surface Cu(111)/Cu(110) with adsorbates Li+/Na+
Authors: Melkozerova J.A. , Gainullin I.K.
Published: September 2023

The influence of the surface type on resonant charge exchange between H−ion with a metal surfaces Cu(111)
and Cu(110) covered by adsorbate Li+/Na+has been studied. A model static problem was considered. For
modeling, athree-dimensional realization of the wave-packet propagation method was used. The Cu(110)
andCu(111) surfaces were described by a pseudopotential, derived from a density functional theory (DFT).An
occupation of H− ion, an electron density dynamics and an ion level width were analyzed. As aresult, we
obtained that an electron oscillates more in case of the surface Cu(111). Furthermore, the resonant charge
exchange is more efficient for Cu(111) surface.
Study of light element activation in human blood during 20 MeV linac operating
Authors: Zheltonozhskaya M.V. , Remizov P.D. , Lenivkin M.V. , Lykova E.N. , Chernyaev A.P. , Iatsenko V.N. , Iatsenko O.V.
Published: September 2023

A series of experiments have been performed to study the activation of chemical macronutrients in human
venous blood throughout radiation treatment with the 20 MeV linac. Some elements in the human blood
can be activated as positron-emitting radionuclides by (𝛾, n)-reaction. We calculated the 11C, 13N, 15O,
30P, 34𝑚Cl, and 38K activities in irradiated human venous blood samples for the first time. As a result, we
concluded that the main contribution to the dose from positron-emitting nuclides activated in human blood
provides three nuclides: 15O, 34𝑚Cl, and 38K.
“Treasures in Hell?” Exploring the Valley of Hinnom in the Biblical Concept of Gehenna and in the Scrolls of Ketef Hinnom
Authors:   University of Santo Tomas, Segovia Jeffrey
Published: September 2023

The title of this paper is intended to capture the two main topics discussed in this exposition with special reference to the Valley of Hinnom in its biblical allusion and as an archeological site. The first presentation is focused on the understanding linked with the place of the Valley of Hinnom especially in the mentions of the place in a number of Biblical occurrences where this valley is being referenced to with allusions to the concept and image of eternal damnation, as a destination for the wicked also known as hell both in the Old and the New Testament and most especially in Jesus’ various usage of the term “Gehenna” in his preaching and ministry. The second part of this exposition is the presentation that explores later archeological discovery from the excavations in the Valley of Hinnom known as the silver scrolls of Ketef Hinnom claimed to be one of the most important Biblical discoveries of antiquity, thus treasures.
Investigating the coverage of speech acts in Hong Kong ELT textbooks
Authors: Wilson Liam
Published: September 2023

In this investigation, speech acts targeted for instruction in ELT (English Language Teaching) textbooks commonly used in Hong Kong were examined using relational content analysis. The aim was to discover which speech acts are frequently presented or not evident, so that this information could be compared to that which has been found in prior studies in other locations. This is important because, from a pedagogical viewpoint, teachers need to ensure textbooks help students learn to use as wide a range of speech acts as possible. As textbooks also need to provide clear examples and information to help learners understand how and when to use speech acts, in this research, the presentation of the speech acts was examined to identify the pragmalinguistic and sociopragmatic information. It was found that there was a tendency to include certain speech acts much more frequently than others, and that some were not included at all. There was also a general lack of clear pragmalinguistic (such as the presentation of indirect speech acts) and sociopragmatic information (such as dealing with high degrees of social distance) presented. This suggests that these factors could be given further consideration and that there are improvements that could be made to both the way that textbooks are written and selected for use. Therefore, this study contributes valuable information about the speech acts in Hong Kong ELT textbooks to and has important implications for both textbook writers and English teachers regarding the field of pragmatics.
Dalit Feminism and the Intersection of Class, Caste and Gender in The Prisons We Broke by Baby Kamble
Authors: Runa  , Sahar Rahman
Published: September 2023

Dalit feminism emerged as a response to mainstream Indian feminism, which tended to downplay caste related issues. Dalit feminism studies not only the patriarchal oppression of Dalit women at the hands of upper-caste men but also from the members within their own caste. Baby Kamble grapples with this issue as a writer as well as an activist. This paper attempts to study the intersectional impact of caste, gender and class in her work The Prisons We Broke using the Dalit feminist theoretical approach. It attempts to analyse the textual representation of Dalit women’s predicament not only through the portrayal of the interlinked complexity of caste, gender and class-based oppressions but also through the intersection and overlapping of these realities within the autobiographical rubric of writing.  In her seminal work, Baby Kamble exposes the deprivation of Dalits and the struggles and oppression of Dalit women. Kamble seems to immerse or place herself within the community but does not leave out the complexity of identity for a Dalit woman. Her autobiography thus disrupts the standard concepts of autobiography that place individual at the centre. As opposed to the existing gap among mainstream feminist movement, there seems to be a scope to reshape feminist solidarity among the Dalit feminist scholarship. This paper builds upon the major concerns shared by Dalit feminists within the social structures that assert the subjugation of Dalit women using the lens of caste and gender. It further attempts to extend the theoretical scope and applicability of Dalit feminism by exploring the conceptual specificity of the social reproduction of the social location-based knowledge of Dalit women’s predicament.
EXAMES DE IMAGEM PARA ESTADIAMENTO DO CÂNCER DE MAMA EM ESTÁGIO INICIAL: ANÁLISE RETROSPECTIVA
Authors: Chambô Filho Antônio , Berriel Pedro Bernardo , Catharino Murilo , Basilio Valentina Vasconcellos , Mule Matheus Passos , Bimbato Lorena Costa , Strozzi Dara Emanuelle Lima , Sossai Davi Roccon
Published: September 2023

O presente trabalho buscou verificar a pertinência de modificar as condutas de solicitação de exames de rastreio para pacientes com câncer de mama em estágio inicial no Hospital Santa Casa de Misericórdia de Vitória (HSCMV). Trata-se de um estudo quantitativo e qualitativo, transversal, retrospectivo, tipo análise documental baseado em dados obtidos em prontuários do HSCMV de 70 pacientes diagnosticadas entre 2018 e 2023. A pesquisa foi realizada em pacientes do sexo feminino, diagnosticadas com câncer de mama com estadiamento inicial (T1-2, N0, M0). Observou-se que nenhuma das pacientes com câncer de mama em estágio inicial teve rastreio metastático positivo. A média de idade ao diagnóstico foi de 57,6 (+ 12,23) anos e o tamanho médio dos tumores foi de 1,4cm. A respeito da imunohistoquímica, a maior parte da amostra era composta por tumores Luminal A (50%, 35 pacientes), seguida de Luminal B (40%, 28 pacientes), Luminal B-HER2 positivo (10%, 7 pacientes). Em relação aos exames utilizados para rastreamento de metástases no momento do diagnóstico, constatou-se que para todas as pacientes (100%) o rastreio foi negativo. Em relação ao estadiamento da neoplasia, foram incluídas apenas pacientes em estágio clínico inicial da doença, configurado por T1 (<2 cm no maior diâmetro), T2 (entre 2 e 5 cm), N0 (sem linfonodos positivos) e M0 (sem metástase). Dessas, obteve-se a seguinte proporção: T1N0M0 (68,57%, 48 pacientes), T2N0M0 (31,43%,22 pacientes). Quanto aos tipos histológicos observados no estudo, houve a seguinte frequência de casos: Carcinoma Ductal Invasivo Grau 2 (61,42%, 43 pacientes), Carcinoma Ductal Invasivo Grau Grau 1 (27,14%, 19 pacientes), Carcinoma Ductal Invasivo Grau 3 (4,28%, 3 pacientes), Carcinoma Lobular Invasivo Grau 1 (4,28%, 3 pacientes), Carcinoma Lobular Invasivo Grau 2 (1,42%, 1 paciente) e Carcinoma Mucinoso Invasivo Grau 2 (1,42%, 1 pacientes). Assim, constatou-se a ausência de metástase ao realizar exames de rastreio metastático em todas as neoplasias classificadas como estágio inicial, confirmando as atuais diretrizes da Sociedade Brasileira de Oncologia Clínica. Portanto, caso a paciente apresente sintomas extra mamários ao diagnóstico, a imunohistoquímica de maior risco (HER 2 e Triplo Negativo) ou evidência de metástase linfonodal (seja no estadiamento clínico ou patológico) é imperativo que se realize o rastreio.
SONS DO SILÊNCIO: A HISTÓRIA DOS SURDOS COM A MÚSICA
Authors: Benites Cristiano da Silva
Published: September 2023

Esta pesquisa visa identificar estudos científicos sobre educação musical de crianças surdas entre 1952 e 2023. Os trabalhos serão analisados para avaliar a integração de tecnologia no ensino. Com base nesses achados, será proposta uma nova abordagem utilizando inteligência artificial para reconhecimento de gestos musicais. Isso visa atender às necessidades das crianças surdas e facilitar seu aprendizado musical de forma independente e divertida. Apesar da controvérsia, pesquisas anteriores mostram a eficácia da educação musical para surdos, e a tecnologia, como demonstrado por aplicativos de IA para aprendizado musical, pode enriquecer essa experiência. A tecnologia é um complemento auxiliar aos métodos tradicionais, removendo barreiras para o ensino de crianças surdas.
Sero-epidemiology of infectious bovine rhinotracheitis and brucellosis in organised dairy farms in southern India
Authors: KRISHNAMOORTHY P , PATIL S S , SHOME RAJESWARI , RAHMAN H
Published: September 2023

The present study was conducted to know the seroprevalence of infectious bovine rhinotracheitis (IBR) and burcellosis and its epidemiology in organised dairy farms in southern India. Sera samples (559) 398 cattle and 161 buffaloes) were collected from 6 organised dairy farms in southern India. Samples were screened for IBR by avidin biotin ELISA and brucellosis by RBPT and indirect ELISA. The overall apparent prevalence were 61.54%, 10.20% and 11.63% for IBR, Brucella by RBPT and iELISA respectively. The state-wise seroprevalence showed highest in Andhra Pradesh for IBR and Karnataka for both IBR and brucellosis; lowest in Tamil Nadu for both the diseases. There was no significant difference in male and female in seroprevalence of these diseases. Crossbred cattle showed high seroprevalence for IBR and Brucella antibodies when compared to indigenous cattle breeds. Buffaloes showed increased seroprevalence for IBR and Brucella when compared to cattle. The IBR seropositive animals showed positive relationship with increase in age. Animals with history of abortions showed seroprevalence of 100% for IBR and 40-50% for brucellosis. The animals with history of reproductive problems showed increased seroprevalence when compared to apparently healthy bovines. The seropositivity for both IBR and brucellosis were 2.76% and 29.19% in cattle and buffaloes, respectively and with overall seropositivity of 10.38%. Thus IBR and brucellosis seroprevalence has increased over the years and there is a need to tackle these diseases effectively by zoosanitary measures and control programmes in organised dairy farms which would benefit the dairying in Southern India.
Comparison of recombinant and whole cell leptospiral antigen against different cattle serovars of leptospira
Authors: PARTHIBAN M , KUMAR S SENTHIL , BALAKRISHNAN G , AARTHI K S
Published: September 2023

The outer membrane protein, viz. OmpL1 of Leptospira interrogans Icterohaemorrhagiae was cloned into pET15b vector. The recombinant colonies were expressed in E. coli BL21 DE3 cells. The expressed proteins were checked in SDS-PAGE and western blot analysis. Similarly, the whole cell antigen was prepared using Leptospira interrogans Icterohaemorrhagiae culture. The cross reactivity of recombinant and whole cell leptospiral antigen against 5 different cattle serovars viz., Hebdomadis, Australis, Hardjo, Pomona, and Ballum were tested using ELISA. All the five cattle serovars gave statistically significant values for cross reaction against recombinant antigen in comparison to whole cell antigen. This clearly indicated that in comparison to whole cell antigen OmpL1 an outer membrane protein cross reacted with different cattle serovars and could be used as an effective diagnostic antigen for leptospirosis.
Fertility response on intrauterine administration of lochial extract in postpartum dairy buffaloes
Authors: CHANDRA V , SHUKLA S N , KUMAR P R , SHRIVASTAVA O P , QUADRI M A
Published: September 2023

The present investigation aimed to assess the effect of intrauterine administration of lochial extract on fertility, uterine bacterial load, serum biochemical and hormonal profiles in postpartum buffaloes. Therefore, experiment was conducted in 30 postpartum buffaloes, randomly divided into 3 groups (10 each). Animals of G 1 received PBS (30 ml) however, in G 2, Lochial extract (30 ml) and in G 3, gentamicin (200 mg) were given as intrauterine infusion on day 15 postpartum. Fertility was ascertained in terms of uterine involution, induction of estrus and conception rate. Bacterial load in uterine contents, serum progesterone, calcium and phosphorus concentrations were also studied before and after the treatments. The uterine involution within 30 days postpartum was highest in both groups 2 and 3 (80% in each). The oestrus induction within 60 days postpartum was also highest in both groups 2 and 3 (60% in each). The conception rate at induced estrus was recorded higher (100%) in lochial extract group followed by gentamicin (83.33%) and control (75%) group. No significant differences were observed in the data of fertility responses. There was significant reduction in bacterial load after treatment in both the treated groups. However, no significant difference was recorded in serum progesterone, calcium and phosphorus neither within the group nor among the groups before and after treatments. Overall results of the present study revealed better and comparable fertility with low uterine bacterial load in postpartum buffaloes administered intrauterine lochial extract and gentamicin.
Population dynamics of insect pests and some of their natural enemies and their correlation with weather parameters on Bt cotton
Authors: MUCHHADIYA D V , SARADAVA D A , KABARIA B B
Published: September 2023

The study was conducted at different villages of Rajkot district (Gujarat) to know the population dynamics and correlation of pests and their natural enemies on Bt cotton from 2008 to 2011. It revealed that sucking pests such as jassid, white fly, thrips, and aphid were found damaging the Bt cotton throughout the season however their peak activity was found on 39th SMW (3.50/3 leaves), 47th SMW (3.48/3 leaves), 38th SMW (2.94/3 leaves) and 51st SMW (27.23%), respectively. Mealy bug appeared from 33rd S M W and reached its peak on 50th SMW (1.95 grades). The peak period of bollworms, heliothis, spotted bollworm, pink bollworm and leaf eating caterpillar were 41st SMW (0.11/pl.), 39th SMW (0.08/pl.), 51st SMW (0.26/pl.) and 41st SMW (0.18/pl.), respectively. In natural enemies chrysopid was found higher in number than spiders and coccinellids throughout the season. The peak periods of the coccinellids, chrysopid and spiders were found on 42nd SMW (0.51/pl.), 45th SMW (3.01/pl.) and 32nd SMW (1.13/pl.), respectively. Correlation amongst sucking pests showed that jassid, whitefly, aphid and mealy bug population showed significant positive correlation with sunshine hours and significant negative association with rainfall whereas thrips showed significant negative correlation with sunshine hours. Amongst bollworms, heliothis, spotted bollworm and leaf eating caterpillar showed significant negative correlation with rainfall whereas spotted bollworm and spodoptera showed significant positive correlation with sunshine hours. Pink bollworm showed significant negative correlation with maximum and minimum temperature and morning and evening relative humidity. In natural enemies, chrysopid and coccinellid showed significant negative correlation with rainfall whereas spiders showed significant positive association with rainfall however chrysopid showed significant positive correlation with sunshine hours.
Effect of irrigation and nutrient management on growth, fibre yield and water use of ramie (Boehmeria nivea)
Authors: MITRA SABYASACHI , KUMAR MUKESH , SAHA MONIDIPTA , MAHAPATRA B S
Published: September 2023

The experiment was conducted at Research Farm of CRIJAF, Barrackpore, Kolkata during 2006 and 2007 with two irrigation regimes (IW/CPE ratio of 0.6 and 0.9) and three nutrient management schedules (100% N from ramie compost, 50% N from ramie compost + 50% N from chemical fertilizer and 100% N from chemical fertilizer based) to determine the effect of irrigation and nutrient management on growth, yield and water use of ramie. Irrigation based on 0.6 IW/CPE ratio recorded higher LAI (7.4-25%), net photosynthetic rate (4.6-9.3%), dry matter (28.5 - 42.8%), fibre yield (23 – 28% ) and water use efficiency (7-19%) of ramie compared to 0.3 IW/CPE ratio irrigation treatment. In second year (2007), the LAI, net photosynthetic rate, fibre yield as well as water use efficiency of the crop receiving INM treatment (50% N from ramie compost + 50% N from inorganic source) was statistically at par to that receiving 100% N from chemical source. The results indicated that application of irrigation to ramie based on IW/CPE ratio of 0.6 and substitution of 50% of the recommended fertilizer nitrogen (15 kg/ha/cut) through integration of ramie compost in the fertilizer schedule of the crop showed better growth and fibre yield of ramie, increased the water use efficiency and economized the requirement of inorganic nitrogen by the crop and can be adopted for commercial cultivation of ramie in south Bengal condition.
Catheter-based serratus anterior plane block vs. continuous wound infiltration for postoperative pain control following minimally invasive atrioventricular valve surgery : a randomized, prospective trial
Authors: Vanden Bussche B , Vandenheuvel M , Moerman A
Published: September 2023

Background: Minimally invasive cardiac surgery via mini-thoracotomy reduces surgical trauma compared to full sternotomy. However, thoracotomy can cause severe postoperative pain. Managing postoperative pain is challenging but critical for fast rehabilitation and avoidance of chronic pain. Our objective was to compare the efficacy of analgesia of a bolus in combination with continuous local anaesthetics using a serratus anterior plane block (SAPB) catheter versus a wound infiltration catheter (CWI) in patients after minimally invasive cardiac surgery.

Design and setting: We conducted a monocentric, prospective, randomized controlled trial between January 2021 and August 2022. The study was performed at Ghent University Hospital, Belgium.

Methods: Patients scheduled for minimally invasive cardiac surgery via thoracoscopy and mini-thoracotomy were randomized to receive either a SABP or a CWI catheter. Postoperatively, continuous ropivacaine 0.2% was started at 10ml/h, and a supplementary bolus of 30ml ropivacaine 0.5% was administered one hour before detubation. The catheter remained in place for at least 24 hours. The primary endpoint was opioid consumption during the first 48 hours postdetubation. Secondary endpoints were anti-emetic consumption, Numerical Analogue Score for 48 hours, length of stay in the Intensive Care Unit and hospital, and incidence of chronic pain. Qualitative data were compared using the Chi – Square test, quantitative data were analyzed with the Student’s t-test.

Results: During the study period, a total of 21 patients received a SAPB catheter and 26 patients received a CWI catheter. No statistical significant differences were seen in baseline characteristics. In the first 48 hours postdetubation, morphine equivalent consumption was similar in both groups (p= 0.52), with no differences observed in the early, mid- or late postoperative phases. The total morphine equivalent dose was 21.8 mg in the SAPB and 18.6 mg in the CWI group. There were no significant differences in postoperative vomiting and nausea, length of stay in the Intensive Care Unit and in the hospital and chronic thoracic pain (23% and 33% for the SAPB and CWI group, respectively, p=0.54).

Conclusion: This prospective study found no significant difference in postoperative opioid consumption between patients who received a serratus anterior plane block catheter and those who received a wound catheter with
bolus and continuous ropivacaine, following minimally invasive cardiac surgery via right thoracoscopy and mini-thoracotomy.
EDUKASI PENGGUNAAN KB SEBAGAI UPAYA PENGATURAN JARAK KEHAMILAN PADA PASANGAN USIA SUBUR (PUS) DI DESA NOBAL KECAMATAN SUNGAI TEBELIAN KABUPATEN SINTANG
Authors: Amartani Rizki
Published: September 2023

Lebih dari 220 juta wanita di dunia ingin merencanakan keluarga dan masa depan mereka tetapi tidak menggunakan metode kontrasepsi modern. Memenuhi kebutuhan mereka akan kontrasepsi dapat menurunkan tingkat kehamilan yang tidak diinginkan, kematian ibu (perempuan meninggal karena hamil/melahirkan) dan kematian bayi yang semuanya adalah target yang tercakup dalam SDGs keluarga berencana yang berperan besar dalam pencapaian SDGs [1]Program Keluarga Berencana (KB) telah berkontribusi terhadap penurunan tingkat kelahiran dan tingkat kematian, yang selanjutnya mengakibatkan penurunan tingkat pertumbuhan penduduk, terutama di negara-negara berkembang termasuk di Indonesia. Banyaknya jumlah wanita yang menggunakan metode kontrasepsi pada suatu waktu tertentu serta kelangsungan pemakaian kontrasepsi berdampak pada efektifitas suatu metode kontrasepsi untuk mencegah terjadinya kehamilan yang tidak diinginkan. Berdasarkan Data Survei Demografi Kesehatan Indonesia (SDKI) yang dilakukan sejak tahun 1994, 1997, 2007 dan 2012 untuk Nasional masing-masing menunjukkan 52,1 persen, 57,4 persen, 61,4 persen dan 58 persen wanita kawin usia 15-49 tahun menggunakan metode kontrasepsi modern. Diantara cara KB modern yang dipakai yaitu suntik KB merupakan alat kontrasepsi terbanyak digunakan oleh wanita berstatus kawin (32 persen), diikuti oleh pil KB, hampir 14 persen[2]Peningkatan kualitas pelayanan keluarga berencana di Indonesia harus fokus dalam menjaga kelangsungan pemakaian metode kontrasepsi. Indikator penting untuk mengukur kualitas pemakaian kontrasepsi adalah angka putus pakai (drop out) metode kontrasepsi. Penggunaan alat kontrasepsi oleh PUS (Pasangan Usia Subur) sangat penting tetapi banyak mengalami putus pakai (drop out) [3].
SOSIALISASI TENTANG PENGGUNAAN KARTU IDENTITAS BEROBAT (KIB) DI PUSKESMAS EMPARU TAHUN 2021
Authors: Herman Joni , Rudiansyah  , Aditya Sardi  , Adventia Natalia Christy  , Theodora Nurcahayana Nainggolan
Published: September 2023

Kartu Identitas Berobat merupakan kartu identitas milik pasien di suatu instansi pelayanan kesehatan. tahun 2020 didapatkan bahwa pasien yang tidak membawa kartu berobat sebanyak 1223. Penyebab pasien tidak membawa kartu yaitu karena lupa dan belum memiliki kartu berobat. Tujuan, untuk mengetahui manfaat penggunaan Kartu Identitas Berobat, untuk mengetahui dampak jika tidak membawa atau memiliki Kartu Identitas Berobat. Metode, Penyampaian materi dengan metode ceramah dan diskusi. Hasil, Peserta sosialisasi mengetahui manfaat penggunaan Kartu Identitas Berobat di buktikan bahwa menurut peserta manfaat Kartu Identitas Berobat memudahkan petugas rekam medis dalam mencari nomor rekam medis pasien, Peserta sosialisasi mengetahui dampak jika tidak membawa atau memiliki Kartu Identitas Berobat, dibuktikan bahwa petugas pendaftaran kesulitan dalam mencari data pasien. Kesimpulan, pentingnya Kartu identitas Berobat memudahkan petugas pendaftaran dalam mencari nomor rekam medis.
PENGARUH KONFLIK KERJA,STRES KERJA DAN BUDAYA ORGANISASI TERHADAP PRESTASI KERJA KARYAWAN PT INDOMARCO PRISMATAMA
Authors: Silaban Deniwati , Purnama Yanthy Herawaty
Published: September 2023

Penelitian ini bertujuan untuk mengetahui pengaruh konflik kerja, stres kerja dan budaya organisasi terhadap kinerja karyawan di PT.Indomarco Prismatama Populasi yang digunakan adalah seluruh karyawan di PT. Indomarco Prismatama dengan sampel sebanyak 63 responden. penelitian ini merupakan penelitian dengan menggunakan sampel jenuh dimana semua populasi dijadikan Sampel. Metode yang digunakan dalam penelitian ini adalah survei dengan menggunakan kuesioner, Analisis data menggunakan analisis deskriptif dan analisis regresi berganda.
Analyzing the Effects of Political Power on Criminal Behavior among Political Elites in Nigeria
Authors: Prince Adamaagashi Izuchukwu
Published: September 2023

This study explores the correlation between political power and criminal behavior among political elites in Nigeria. It utilizes a qualitative methodology, including a thorough examination of existing literature, to understand the nature and consequences of criminal behavior in Nigeria. The study finds that socioeconomic inequality is a key factor influencing criminal behavior, and factors contributing to criminal behavior among political elites include weak law enforcement, corruption, and a culture of deviance. The study applies theoretical frameworks such as strain theory, social disorganization theory, rational choice theory, and elite theory to analyze the effects of political power on criminal behavior among political elites. Institutional factors play a significant role, and the level of transparency within institutional frameworks plays a crucial role in shaping the behavior of political elites. Criminal networks and power consolidation pose ongoing challenges for the government, with various criminal activities prevalent in Nigeria. The study recommends strengthening law enforcement and the legal system, enhancing transparency and accountability, combating corruption and bribery, strengthening oversight institutions, addressing socio-cultural factors, fostering international collaboration, promoting public accountability and civil society engagement, and establishing strong institutions to mitigate the influence of political power on criminal behavior. In conclusion, this study provides insights into the close connection between political power and criminal behavior in Nigeria, emphasizing the need for interventions and reforms to address this issue.