bluuebunny/crossref_metadata_2025 huggingface dataset:
Potential Effect of the Intrusion of the Kuroshio Current into the South China Sea on Catches of Japanese Eel (Anguilla Japonica) in the South China Sea and Taiwan Strait
Authors: Ho Ching-Hsien , Wu Long-Jing , Lu Zhen , Lu Bo-Yi , Lan Yang-Chi
Published: December 2021

This study examined the effect of the intrusion of the Kuroshio Current (KC) into the South China Sea (SCS) and the Taiwan Strait (TS) (SCS–TS region) on changes in catches of larval A. japonica in the traditional fishing ground waters of Gaoping near southwestern Taiwan in the SCS–TS region. First, the oceanic environment and recruitment trends from 1967 to 2019 were investigated based on secondary data. Then, field surveys were conducted to obtain primary data regarding the intrusion of the KC into the SCS, as well as the changes in the fishing sites and catches of A. japonica in the fall and winter of 2014–2015. Hence, the association between oceanic conditions and the number of A. japonica migrating into the SCS–TS region was explored. From 1967 to 2019, the recruitment proportion in the fishing grounds that formed due to the Kuroshio Branch Current (PKSBC) fluctuated significantly. Overall, positive values were observed for the Oceanic Niño Index for each year with a PKSBC > 50%, corresponding to El Niño conditions. In each year with a PKSBC > 70%, a looping path and a warm–core eddy appeared.
High Efficiency In Vitro Wound Healing of Dictyophora indusiata Extracts via Anti-Inflammatory and Collagen Stimulating (MMP-2 Inhibition) Mechanisms
Authors: Nazir Yasir , Linsaenkart Pichchapa , Khantham Chiranan , Chaitep Tanakarn , Jantrawut Pensak , Chittasupho Chuda , Rachtanapun Pornchai , Jantanasakulwong Kittisak , Phimolsiripol Yuthana , Sommano Sarana Rose , Tocharus Jiraporn , Mingmalairak Salin , Wongsa Anchali , Arjin Chaiwat , Sringarm Korawan , Berrada Houda , Barba Francisco J. , Ruksiriwanich Warintorn
Published: December 2021

Dictyophora indusiata or Phallus indusiatus is widely used as not only traditional medicine, functional foods, but also, skin care agents. Biological activities of the fruiting body from D. indusiata were widely reported, while the studies on the application of immature bamboo mushroom extracts were limited especially in the wound healing effect. Wound healing process composed of 4 stages including hemostasis, inflammation, proliferation, and remodelling. This study divided the egg stage of bamboo mushroom into 3 parts: peel and green mixture (PGW), core (CW), and whole mushroom (WW). Then, aqueous extracts were investigated for their nucleotide sequencing, biological compound contents, and wound healing effect. The anti-inflammatory determination via the levels of cytokine releasing from macrophages, and the collagen stimulation activity on fibroblasts by matrix metalloproteinase-2 (MMP-2) inhibitory activity were determined to serve for the wound healing process promotion in the stage 2–4 (wound inflammation, proliferation, and remodelling of the skin). All D. indusiata extracts showed good antioxidant potential, significantly anti-inflammatory activity in the decreasing of the nitric oxide (NO), interleukin-1 (IL-1), interleukin-1 (IL-6), and tumour necrosis factor-α (TNF-α) secretion from macrophage cells (p < 0.05), and the effective collagen stimulation via MMP-2 inhibition. In particular, CW extract containing high content of catechin (68.761 ± 0.010 mg/g extract) which could significantly suppress NO secretion (0.06 ± 0.02 µmol/L) better than the standard anti-inflammatory drug diclofenac (0.12 ± 0.02 µmol/L) and their MMP-2 inhibition (41.33 ± 9.44%) was comparable to L-ascorbic acid (50.65 ± 2.53%). These findings support that CW of D. indusiata could be an essential natural active ingredient for skin wound healing pharmaceutical products.
New Dothideomycetes from Freshwater Habitats in Spain
Authors: Magaña-Dueñas Viridiana , Cano-Lira José Francisco , Stchigel Alberto Miguel
Published: December 2021

The Dothideomycetes are a class of cosmopolitan fungi that are present principally in terrestrial environments, but which have also been found in freshwater and marine habitats. In the present study, more than a hundred samples of plant debris were collected from various freshwater locations in Spain. Its incubation in wet chambers allowed us to detect and to isolate in pure culture numerous fungi producing asexual reproductive fruiting bodies (conidiomata). Thanks to a morphological comparison and to a phylogenetic analysis that combined the internal transcribed spacer (ITS) region of the nrDNA with fragments of the RNA polymerase II subunit 2 (rpb2), beta tubulin (tub2), and the translation elongation factor 1-alpha (tef-1) genes, six of those strains were identified as new species to science. Three belong to the family Didymellaceae: Didymella brevipilosa, Heterophoma polypusiformis and Paraboeremia clausa; and three belong to the family Phaeosphaeriaceae:Paraphoma aquatica, Phaeosphaeria fructigena and Xenophoma microspora. The finding of these new taxa significantly increases the number of the coelomycetous fungi that have been described from freshwater habitats.
Non-Negligible Effects of UV Irradiation on Transformation and Environmental Risks of Microplastics in the Water Environment
Authors: Cheng Fangyuan , Zhang Tingting , Liu Yue , Zhang Yanan , Qu Jiao
Published: December 2021

Microplastics (MPs) are ubiquitous in environmental media, and their harmful effects on MPs on the ecosystem have attracted more and more attention. Once released into the environment, MPs can trigger oxidative degradation through ultraviolet (UV) to cause photoaging. Photoaging significantly affects the properties of MPs, which leads to changing their environmental behaviors and increasing environmental risks. In this review, the generation of MPs under UV irradiation and the influence of environmental factors on the photoaging of MPs were discussed. Photoaging of MPs is an important process affecting the migration, transformation and interaction of pollutants in water and soil. In order to fully predict the fate and environmental interaction of MPs, more researches are needed in the future to explore the photoaging behavior of different types of MPs under natural environmental conditions.
Microstructure and Defect-Based Fatigue Mechanism Evaluation of Brazed Coaxial Ti/Al2O3 Joints for Enhanced Endoprosthesis Design
Authors: Otto Johannes L. , Fedotov Ivan , Penyaz Milena , Schaum Thorge , Kalenborn Anke , Kalin Boris , Sevryukov Oleg , Walther Frank
Published: December 2021

Alumina-based ceramic hip endoprosthesis heads have excellent tribological properties, such as low wear rates. However, stress peaks can occur at the point of contact with the prosthesis stem, increasing the probability of fracture. This risk should be minimized, especially for younger and active patients. Metal elevations at the stem taper after revision surgery without removal of a well-fixed stem are also known to increase the risk of fracture. A solution that also eliminates the need for an adapter sleeve could be a fixed titanium insert in the ceramic ball head, which would be suitable as a damping element to reduce the occurrence of stress peaks. A viable method for producing such a permanent titanium–ceramic joint is brazing. Therefore, a brazing method was developed for coaxial samples, and two modifications were made to the ceramic surface to braze a joint that could withstand high cyclic loading. This cyclic loading was applied in multiple amplitude tests in a self-developed test setup, followed by fractographic studies. Computed tomography and microstructural analyses—such as energy dispersive X-ray spectroscopy—were also used to characterize the process–structure–property relationships. It was found that the cyclic loading capacity can be significantly increased by modification of the surface structure of the ceramic.
Effects of Temperature on the Evolution of Yield Surface and Stress Asymmetry in A356–T7 Cast Aluminium Alloy
Authors: Natesan Elanghovan , Ahlström Johan , Eriksson Stefan , Persson Christer
Published: December 2021

As the electrification of vehicle powertrains takes prominence to meet stringent emission norms, parts of internal combustion engines like cylinder heads are subjected to an increased number of thermal load cycles. The cost-effective design of such structures subjected to cyclic thermo-mechanical loads relies on the development of accurate material models capable of describing the continuum deformation behaviour of the material. This study investigates the effect of temperature on the evolution of flow stress under cyclic loading in A356-T7 + 0.5% Cu cast aluminium alloy commonly used in modern internal combustion engine cylinder heads. The material exhibits peak stress and flow stress asymmetry with the stress response and flow stress of the material under compressive loading higher than under tension. This peak and flow stress asymmetry decrease with an increase in temperature. To compare this stress asymmetry against conventional steel, cyclic strain-controlled fatigue tests are run on fully pearlitic R260 railway steel material. To study the effect of mean strain on the cyclic mean stress evolution and fatigue behaviour of the alloy, tests with tensile and compressive mean strains of +0.2% and −0.2% are compared against fully reversed (Rε = −1) strain-controlled tests. The material exhibits greater stress asymmetry between the peak tensile and peak compressive stresses for the strain-controlled tests with a compressive mean strain than the tests with an identical magnitude tensile mean strain. The material exhibits mean stress relaxation at all temperatures. Reduced durability of the material is observed for the tests with tensile mean strains at lower test temperatures of up to 150 °C. The tensile mean strains at elevated temperatures do not exhibit such a detrimental effect on the endurance limit of the material.
The Impact of Hydrogenation on Structural and Superconducting Properties of FeTe0.65Se0.35 Single Crystals
Authors: Bondarenko Stanislav I. , Prokhvatilov Anatolij I. , Puźniak Roman , Piętosa Jarosław , Prokhorov Andrey A. , Meleshko Vladimir V. , Timofeev Valeriy P. , Koverya Valentin P. , Gawryluk Dariusz Jakub , Wiśniewski Andrzej
Published: December 2021

Properties of FeTe0.65Se0.35 single crystals, with the onset of critical temperature (Tconset) at 15.5 K, were modified via hydrogenation performed for 10–90 h, at temperatures ranging from 20 to 250 °C. It was found that the tetragonal matrix became unstable and crystal symmetry lowered for the samples hydrogenated already at 200 °C. However, matrix symmetry was not changed and the crystal was not destroyed after hydrogenation at 250 °C. Bulk Tcbulk, determined at the middle of the superconducting transition, which is equal to 12–13 K for the as grown FeTe0.65Se0.35, rose by more than 1 K after hydrogenation. The critical current density studied in magnetic field up to 70 kOe increased 4–30 times as a consequence of hydrogenation at 200 °C for 10 h. Electron paramagnetic resonance measurements also showed higher values of Tcbulk for hydrogenated crystals. Thermal diffusion of hydrogen into the crystals causes significant structural changes, leads to degeneration of crystal quality, and significantly alters superconducting properties. After hydrogenation, a strong correlation was noticed between the structural changes and changes in the parameters characterizing the superconducting state.
Modification of Glass/Polyester Laminates with Flame Retardants
Authors: Dowbysz Adriana , Samsonowicz Mariola , Kukfisz Bożena
Published: December 2021

This paper presents a review of flame retardants used for glass/polyester laminates. It concerns flame retardants withdrawn from use such as compounds containing halogen atoms and flame retardants currently used in the industry, such as inorganic hydroxides, phosphorus and nitrogen-containing compounds, antimony, and boron compounds, as well as tin–zinc compounds. Attention is also drawn to the use of nanoclays and the production of nanocomposites, intumescent flame retardant systems, and mats, as well as polyhedral oligomeric silsesquioxanes. The paper discusses the action mechanism of particular flame retardants and presents their advantages and disadvantages.
Versatile Strategy for Electrophoretic Deposition of Polyvinylidene Fluoride-Metal Oxide Nanocomposites
Authors: Zhao Qinfu , Liu Xinqian , Veldhuis Stephen , Zhitomirsky Igor
Published: December 2021

Polyvinylidene fluoride (PVDF) is an advanced functional polymer which exhibits excellent chemical and thermal stability, and good mechanical, piezoelectric and ferroelectic properties. This work opens a new strategy for the fabrication of nanocomposites, combining the functional properties of PVDF and advanced inorganic nanomaterials. Electrophoretic deposition (EPD) has been developed for the fabrication of films containing PVDF and nanoparticles of TiO2, MnO2 and NiFe2O4. An important finding was the feasibility of EPD of electrically neutral PVDF and inorganic nanoparticles using caffeic acid (CA) and catechol violet (CV) as co-dispersants. The experiments revealed strong adsorption of CA and CV on PVDF and inorganic nanoparticles, which involved different mechanisms and facilitated particle dispersion, charging and deposition. The analysis of the deposition yield data, chemical structure of the dispersants and the microstructure and composition of the films provided an insight into the adsorption and dispersion mechanisms and the influence of deposition conditions on the deposition rate, film microstructure and composition. PVDF films provided the corrosion protection of stainless steel. Overcoming the limitations of other techniques, this investigation demonstrates a conceptually new approach for the fabrication of PVDF-NiFe2O4 films, which showed superparamagnetic properties. The approach developed in this investigation offers versatile strategies for the EPD of advanced organic-inorganic nanocomposites.
Pitting Corrosion Behavior and Surface Microstructure of Copper Strips When Rolled with Oil-in-Water Emulsions
Authors: Yan Xudong , Sun Jianlin
Published: December 2021

Copper strips experience severe corrosion when rolled with an oil-in-water (O/W) emulsions lubricant. The effects of rolling reduction on the pitting corrosion behavior and surface microstructure of Cu strips were studied in detail using electrochemical measurements and electron back scattered diffraction (EBSD) analysis. It was found that the corrosion current densities of the rolled Cu strips increased with accumulated reduction, which also lowered the pitting potentials and weakened their corrosion resistances. Therefore, the corrosive tendency of Cu strips under different rolling reductions (ε) followed the order of ε0% < ε20.7% < ε50.6% < ε77.3%. The Cu surface easily reacted with chlorine, sulfur, and carbon components from O/W emulsions to generate pitting corrosion. Under the interactive effect of pitting corrosion and stress corrosion, pits expanded along the rolling direction. The aggregation of anions in surface defects, such as dislocations, metastable pits, and microcracks, further accelerated the pitting corrosion of the surface.
Dual Thermo- and Photo-Responsive Micelles Based on Azobenzene-Containing Random Copolymer
Authors: Yan Chuan , Yang Liqin , Mo Xiangquan , Chen Keying , Niu Weiya , Zhao Zhiju , Li Guanghua
Published: December 2021

Amphiphilic random copolymer poly(methacrylamido-azobenzene)-ran-poly(2-hydroxyethylacrylate) (PMAAAB-ran-PHEA) was synthesized via hydrolysis of poly(methacrylamido-azobenzene)-ran-poly[2-((2′-tetrahydropyranyl)oxy)ethylacrylate] (PMAAAB-ran-P(THP-HEA)), which was prepared by conventional radical polymerization. PMAAAB-ran-PHEA micelles were then prepared via dialysis method against water with DMF as solvent. The structure, morphology, size, and low critical solution temperature (LCST) of PMAAAB-ran-PHEA and its micelles were determined by 1H-NMR, GPC, TEM, and DLS. The thermo- and photo-responsive behaviors of the resulting polymer micelles were investigated with Nile red as a fluorescence probe. The results showed that PMAAAB-ran-PHEA micelles were porous or bowl-shaped and its size was 135–150 nm, and its LCST was 55 °C when FMAAAB of the random copolymer was 0.5351; the hydrophobicity of the micellar core was changed reversibly under the irradiation of UV light and visible light without release of Nile red or disruption of micelles; the size and solubilization capacity of the micelles were dependent on temperature, and Nile red would migrate for many times between the water phase and the micelles, and finally increasingly accumulated during the repeated heating and cooling processes.
Ionization Radiation Shielding Effectiveness of Lead Acetate, Lead Nitrate, and Bismuth Nitrate-Doped Zinc Oxide Nanorods Thin Films: A Comparative Evaluation
Authors: Al-Balushi Mohamed Abdulsattar , Ahmed Naser M. , Zyoud Samer H. , Mohammed Ali Mohammed Khalil , Akhdar Hanan , Aldaghri Osamah A. , Ibnaouf Khalid Hassan
Published: December 2021

The fabrication of Nano-based shielding materials is an advancing research area in material sciences and nanotechnology. Although bulky lead-based products remain the primary choice for radiation protection, environmental disadvantages and high toxicity limit their potentials, necessitating less costly, compatible, eco-friendly, and light-weight alternatives. The theme of the presented investigation is to compare the ionization radiation shielding potentialities of the lead acetate (LA), lead nitrate (LN), and bismuth nitrate (BN)-doped zinc oxide nanorods-based thin films (ZONRs-TFs) produced via the chemical bath deposition (CBD) technique. The impact of the selected materials’ doping content on morphological and structural properties of ZONRs-TF was investigated. The X-ray diffractometer (XRD) analyses of both undoped and doped TFs revealed the existence of hexagonal quartzite crystal structures. The composition analysis by energy dispersive (EDX) detected the corrected elemental compositions of the deposited films. Field emission scanning electronic microscope (FESEM) images of the TFs showed highly porous and irregular surface morphologies of the randomly aligned NRs with cracks and voids. The undoped and 2 wt.% BN-doped TFs showed the smallest and largest grain size of 10.44 nm and 38.98 nm, respectively. The linear attenuation coefficient (µ) values of all the optimally doped ZONRs-TFs measured against the X-ray photon irradiation disclosed their excrement shielding potency. The measured µ values of the ZONRs-TFs displayed the trend of 1 wt.% LA-doped TF > 1 wt.% LN-doped TF > 3 wt.% BN-doped TF > undoped TFs). The values of μ of the ZONRs-TFs can be customized by adjusting the doping contents, which in turn controls the thickness and morphology of the TFs. In short, the proposed new types of the LA-, LN- and BN-doped ZONRs-TFs may contribute towards the development of the prospective ionization radiation shielding materials.
Layer-by-Layer Electrode Fabrication for Improved Performance of Porous Polyimide-Based Supercapacitors
Authors: Fernando Niranjala , Veldhuizen Hugo , Nagai Atsushi , van der Zwaag Sybrand , Abdelkader Amor
Published: December 2021

Nanoporous polymers are becoming increasingly interesting materials for electrochemical applications, as their large surface areas with redox-active sites allow efficient adsorption and diffusion of ions. However, their limited electrical conductivity remains a major obstacle in practical applications. The conventional approach that alleviates this problem is the hybridisation of the polymer with carbon-based additives, but this directly prevents the utilisation of the maximum capacity of the polymers. Here, we report a layer-by-layer fabrication technique where we separated the active (porous polymer, top) layer and the conductive (carbon, bottom) layer and used these “layered” electrodes in a supercapacitor (SC). Through this approach, direct contact with the electrolyte and polymer material is greatly enhanced. With extensive electrochemical characterisation techniques, we show that the layered electrodes allowed a significant contribution of fast faradic surface reactions to the overall capacitance. The electrochemical performance of the layered-electrode SC outperformed other reported porous polymer-based devices with a specific gravimetric capacitance of 388 F·g−1 and an outstanding energy density of 65 Wh·kg−1 at a current density of 0.4 A·g−1. The device also showed outstanding cyclability with 90% of capacitance retention after 5000 cycles at 1.6 A·g−1, comparable to the reported porous polymer-based SCs. Thus, the introduction of a layered electrode structure would pave the way for more effective utilisation of porous organic polymers in future energy storage/harvesting and sensing devices by exploiting their nanoporous architecture and limiting the negative effects of the carbon/binder matrix.
Impact of Methanol Concentration on Properties of Ultra-Nanocrystalline Diamond Films Grown by Hot-Filament Chemical Vapour Deposition
Authors: Mosińska Lidia , Szczęsny Robert , Trzcinski Marek , Naparty Mieczysław Karol
Published: December 2021

Diamond is a very interesting material with a wide range of properties, making it highly applicable, for example, in power electronics, chemo- and biosensors, tools’ coatings, and heaters. Due to the high demand for this innovative material based on the properties it is already expected to have, it is important to obtain homogeneous diamond layers for specific applications. Doping is often chosen to modify the properties of layers. However, there is an alternative way to achieve this goal and it is shown in this publication. The presented research results reveal that the change in methanol content during the Hot Filament Chemical Vapour Deposition (HF CVD) process is a sufficient factor to tune the properties of deposited layers. This was confirmed by analysing the properties of the obtained layers, which were determined using Raman spectroscopy, scanning electron microscopy (SEM), X-ray diffraction (XRD), and an atomic force microscope (AFM), and the results were correlated with those of X-ray photoelectron spectroscopy (XPS). The results showed that the increasing of the concentration of methanol resulted in a slight decrease in the sp3 phase content. At the same time, the concentration of the -H, -OH, and =O groups increased with the increasing of the methanol concentration. This affirmed that by changing the content of methanol, it is possible to obtain layers with different properties.
Correlation of Statistical Distributions of the Dimension of Yeast Cells Attached to the Substrate and Its Surface Electrical Potential
Authors: Bondareva Elina , Dekhtyar Yuri , Gorosko Vladislavs , Sorokins Hermanis , Rapoport Alexander
Published: December 2021

The ability of cells to adhere to substrates is an important factor for the effectiveness of biotechnologies and bioimplants. This research demonstrates that the statistical distribution of the sizes of the cells (Saccharomyces cerevisiae) attached to the substrate surface correlates with the statistical distribution of electrical potential on the substrate’s surface. Hypothetically, this behavior should be taken into consideration during the processing of surfaces when cell adhesion based on cell size is required.
Evolution of Annealing Twins in a Hot Deformed Nickel-Based Superalloy
Authors: Xia Yu-Chi , Chen Xiao-Min , Lin Yong-Cheng , Lu Xian-Zheng
Published: December 2021

The hot deformation characteristics of a GH4169 superalloy are investigated at the temperature and strain rate ranges of 1193–1313 K and 0.01–1 s−1, respectively, through Gleeble-3500 simulator. The hot deformed microstructures are analyzed by optical microscopy (OM), transmission electron microscopy (TEM), and electron backscattered diffraction (EBSD) technology. The effects of deformation parameters on the features of flow curves and annealing twins are discussed in detail. It is found that the shapes of flow curves are greatly affected by the deformation temperature. Broad peaks appear at low deformation temperatures or high strain rates. In addition, the evolution of annealing twins is significantly sensitive to the deformation degree, temperature, and strain rate. The fraction of annealing twins first decreases and then rises with the added deformation degree. This is because the initial annealing twin characters disappear at the relatively small strains, while the annealing twins rapidly generate with the growth of dynamic recrystallized grains during the subsequent hot deformation. The fraction of annealing twins is relatively high when the deformation temperature is high or the strain rate is low. In addition, the important role of annealing twins on dynamic recrystallization (DRX) behaviors are elucidated. The obvious bulging at initial twin boundaries, and the coherency of annealing twin boundaries with dynamic recrystallized grain boundaries, indicates that annealing twins can motivate the DRX nucleation during the hot deformation.
Quantum Hall Effect across Graphene Grain Boundary
Authors: Chau Tuan Khanh , Suh Dongseok , Kang Haeyong
Published: December 2021

Charge carrier scattering at grain boundaries (GBs) in a chemical vapor deposition (CVD) graphene reduces the carrier mobility and degrades the performance of the graphene device, which is expected to affect the quantum Hall effect (QHE). This study investigated the influence of individual GBs on the QH state at different stitching angles of the GB in a monolayer CVD graphene. The measured voltage probes of the equipotential line in the QH state showed that the longitudinal resistance (Rxx) was affected by the scattering of the GB only in the low carrier concentration region, and the standard QHE of a monolayer graphene was observed regardless of the stitching angle of the GB. In addition, a controlled device with an added metal bar placed in the middle of the Hall bar configuration was introduced. Despite the fact that the equipotential lines in the controlled device were broken by the additional metal bar, only the Rxx was affected by nonzero resistance, whereas the Hall resistance (Rxy) revealed the well-quantized plateaus in the QH state. Thus, our study clarifies the effect of individual GBs on the QH states of graphenes.
Microwave-Assisted Synthesis of Nitrogen and Sulphur Doped Graphene Decorated with Antimony Oxide: An Effective Catalyst for Oxygen Reduction Reaction
Authors: Garino Nadia , Sacco Adriano , Chiodoni Angelica , Pirri Candido F. , Castellino Micaela
Published: December 2021

In this study, we report on the facile synthesis of a novel electrocatalysts for the oxygen reduction reaction (ORR), based on reduced graphene oxide (RGO), functionalized with metallic and non-metallic elements. In particular, thanks to a fast one-pot microwave-assisted procedure, we induced, in the RGO graphene lattice, a combined doping with nitrogen and sulphur, and the simultaneous decoration with antimony oxide nanocrystals. The multi-doped–decorated material shows enhanced catalytic performance towards ORR, with respect to common nitrogen- or sulphur-doped carbon-based materials. The presence of co-doping is confirmed by transmission electron microscopy and X-ray photoelectron spectroscopy analysis. The detailed electrochemical characterization shows the simultaneous effects of dopant atoms on the catalytic behavior. In particular, the importance of nitrogen and sulphur atoms in driving the oxygen absorption, together with the role of antimony in enhancing the electrochemical performance toward the ORR, are discussed.
Collagen/Chitosan Gels Cross-Linked with Genipin for Wound Healing in Mice with Induced Diabetes
Authors: Shagdarova Balzhima , Konovalova Mariya , Zhuikova Yuliya , Lunkov Alexey , Zhuikov Vsevolod , Khaydapova Dolgor , Il’ina Alla , Svirshchevskaya Elena , Varlamov Valery
Published: December 2021

Diabetes mellitus continues to be one of the most common diseases often associated with diabetic ulcers. Chitosan is an attractive biopolymer for wound healing due to its biodegradability, biocompatibility, mucoadhesiveness, low toxicity, and hemostatic effect. A panel of hydrogels based on chitosan, collagen, and silver nanoparticels were produced to treat diabetic wounds. The antibacterial activity, cytotoxicity, swelling, rheological properties, and longitudinal sections of hydrogels were studied. The ability of the gels for wound healing was studied in CD1 mice with alloxan-induced diabetes. Application of the gels resulted in an increase in VEGF, TGF-b1, IL-1b, and TIMP1 gene expression and earlier wound closure in a comparison with control untreated wounds. All gels increased collagen deposition, hair follicle repair, and sebaceous glands formation. The results of these tests show that the obtained hydrogels have good mechanical properties and biological activity and have potential applications in the field of wound healing. However, clinical studies are required to compare the efficacy of the gels as animal models do not reproduce full diabetes pathology.
Bacterial Nanocellulose Fortified with Antimicrobial and Anti-Inflammatory Natural Products from Chelidonium majus Plant Cell Cultures
Authors: Zielińska Sylwia , Matkowski Adam , Dydak Karolina , Czerwińska Monika Ewa , Dziągwa-Becker Magdalena , Kucharski Mariusz , Wójciak Magdalena , Sowa Ireneusz , Plińska Stanisława , Fijałkowski Karol , Ciecholewska-Juśko Daria , Broda Michał , Gorczyca Damian , Junka Adam
Published: December 2021

In this work we developed a bi-functional Bacterial-Nano-Cellulose (BNC) carrier system for cell cultures of Chelidonium majus—a medicinal plant producing antimicrobial compounds. The porous BNC was biosynthesized for 3, 5 or 7 days by the non-pathogenic Komagataeibacter xylinus bacteria and used in three forms: (1) Without removal of K. xylinus cells, (2) partially cleaned up from the remaining K. xylinus cells using water washing and (3) fully purified with NaOH leaving no bacterial cells remains. The suspended C. majus cells were inoculated on the BNC pieces in liquid medium and the functionalized BNC was harvested and subjected to scanning electron microscopy observation and analyzed for the content of C. majus metabolites as well as to antimicrobial assays and tested for potential proinflammatory irritating activity in human neutrophils. The highest content and the most complex composition of pharmacologically active substances was found in 3-day-old, unpurified BNC, which was tested for its bioactivity. The assays based on the IL-1β, IL-8 and TNF-α secretion in an in vitro model showed an anti-inflammatory effect of this particular biomatrix. Moreover, 3-day-old-BNC displayed antimicrobial and antibiofilm activity against Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans. The results of the research indicated a possible application of such modified composites, against microbial pathogens, especially in local surface infections, where plant metabolite-enriched BNC may be used as the occlusive dressing.
Qualitative Evaluation of the Effects of Professional Oral Hygiene Instruments on Prosthetic Ceramic Surfaces
Authors: Grande Francesco , Mochi Zamperoli Edoardo , Pozzan Mario Cesare , Tesini Fabio , Catapano Santo
Published: December 2021

During professional hygiene procedures, different instruments used may cause various damage to dental prostheses. Deplaquing and scaling with curettes and ultrasonic instruments may inadvertently increase the surface roughness of the material and the risk of future bacterial adhesion and/or also compromise the marginal seal of the prosthesis. Hence, the aim of this study was to assess the qualitative effects of two types of curettes and one piezoelectric instrument with a stainless-steel tip on three types of metal-free samples. After treating the samples with different instrumentations, they were analyzed using the scanning electron microscope and then underwent a qualitative microanalysis by using a spectroscopy machine. All the materials tested in this study have undergone significant changes of their superficial structure after instrumentation both with mechanical and manual instruments. Plastic curettes appeared to be less aggressive than the other instruments. Disilicate samples show a significantly lower degree of surface glazing erosion compared to the zirconia sample with all the instruments used.
Similitude for the Dynamic Characteristics of Dual-Rotor System with Bolted Joints
Authors: Li Lei , Luo Zhong , He Fengxia , Qin Zhaoye , Li Yuqi , Yan Xiaolu
Published: December 2021

The dual-rotor system has been widely used in aero-engines and has the characteristics of large axial size, the interaction between the high-pressure rotor and low-pressure rotor, and stiffness nonlinearity of bolted joints. However, the testing of a full-scale dual-rotor system is expensive and time-consuming. In this paper, the scaling relationships for the dual-rotor system with bolted joints are proposed for predicting the responses of full-scale structure, which are developed by generalized and fundamental equations of substructures (shaft, disk, and bolted joints). Different materials between prototype and model are considered in the derived scaling relationships. Moreover, the effects of bolted joints on the dual-rotor system are analyzed to demonstrate the necessity for considering bolted joints in the similitude procedure. Furthermore, the dynamic characteristics for different working conditions (low-pressure rotor excitation, high-pressure rotor excitation, two frequency excitations, and counter-rotation) are predicted by the scaled model made of a relatively cheap material. The results show that the critical speeds, vibration responses, and frequency components can be predicted with good accuracy, even though the scaled model is made of different materials.
A Closed-Form Pricing Formula for Log-Return Variance Swaps under Stochastic Volatility and Stochastic Interest Rate
Authors: Mao Chen , Liu Guanqi , Wang Yuwen
Published: December 2021

At present, the study concerning pricing variance swaps under CIR the (Cox–Ingersoll–Ross)–Heston hybrid model has achieved many results; however, due to the instantaneous interest rate and instantaneous volatility in the model following the Feller square root process, only a semi-closed solution can be obtained by solving PDEs. This paper presents a simplified approach to price log-return variance swaps under the CIR–Heston hybrid model. Compared with Cao’s work, an important feature of our approach is that there is no need to solve complex PDEs; a closed-form solution is obtained by applying the martingale theory and Ito^’s lemma. The closed-form solution is significant because it can achieve accurate pricing and no longer takes time to adjust parameters by numerical method. Another significant feature of this paper is that the impact of sampling frequency on pricing formula is analyzed; then the closed-form solution can be extended to an approximate formula. The price curves of the closed-form solution and the approximate solution are presented by numerical simulation. When the sampling frequency is large enough, the two curves almost coincide, which means that our approximate formula is simple and reliable.
New Results on F-Contractions in Complete Metric Spaces
Authors: Vujaković Jelena , Kontrec Nataša , Tošić Marina , Fabiano Nicola , Radenović Stojan
Published: December 2021

The main purpose of this paper is to improve, generalize, unify, extend and enrich the recent results established by Dung and Hang (2015), Piri and Kumam (2014, 2016), and Singh et al. (2018). In our proofs, we only use the property (F1) of Wardowski’s F-contraction, while the many authors in their papers still use all tree properties of F-contraction as well as two new properties introduced by Piri and Kumam. Our approach in this paper indicates that for most results with F-contraction, property (F1) is sufficient. It is interesting to investigate whether (F1) is sufficient in the case of multi-valued mappings.
A Districting Application with a Quality of Service Objective
Authors: Álvarez-Miranda Eduardo , Pereira Jordi
Published: December 2021

E-commerce sales have led to a considerable increase in the demand for last-mile delivery companies, revealing several problems in their logistics processes. Among these problems, are not meeting delivery deadlines. For example, in Chile, the national consumer service (SERNAC) indicated that in 2018, late deliveries represented 23% of complaints in retail online sales and were the second most common reason for complaints. Some of the causes are incorrectly designed delivery zones because in many cases, these delivery zones do not account for the demographic growth of cities. The result is an imbalanced workload between different zones, which leads to some resources being idle while others fail to meet their workload in satisfactory conditions. The present work proposes a hybrid method for designing delivery zones with an objective based on improving the quality of express delivery services. The proposed method combines a preprocess based on the grouping of demand in areas according to the structure of the territory, a heuristic that generates multiple candidates for the distribution zones, and a mathematical model that combines the different distribution zones generated to obtain a final territorial design. To verify the applicability of the proposed method, a case study is considered based on the real situation of a Chilean courier company with low service fulfillment in its express deliveries. The results obtained from the computational experiments show the applicability of the method, highlighting the validity of the aggregation procedure and improvements in the results obtained using the hybrid method compared to the initial heuristic. The final solution improves the ability to meet the conditions associated with express deliveries, compared with the current situation, by 12 percentage points. The results also allow an indicative sample of the critical service factors of a company to be obtained, identifying the effects of possible changes in demand or service conditions.
Mansouramycins E–G, Cytotoxic Isoquinolinequinones from Marine Streptomycetes
Authors: Shaaban Mohamed , Shaaban Khaled A. , Kelter Gerhard , Fiebig Heinz Herbert , Laatsch Hartmut
Published: December 2021

Chemical investigation of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate B1848 resulted in three new isoquinolinequinone derivatives, the mansouramycins E–G (1a–3a), in addition to the previously reported mansouramycins A (5) and D (6). Their structures were elucidated by computer-assisted interpretation of 1D and 2D NMR spectra, high-resolution mass spectrometry, and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated a significant cytotoxicity and good tumor selectivity for mansouramycin F (2a), while the activity profile of E (1a) was less attractive.
Transcriptomic and Proteomic Characterizations of the Molecular Response to Blue Light and Salicylic Acid in Haematococcus pluvialis
Authors: Wang Xiaodong , Meng Chunxiao , Zhang Hao , Xing Wei , Cao Kai , Zhu Bingkui , Zhang Chengsong , Sun Fengjie , Gao Zhengquan
Published: December 2021

Haematococcus pluvialis accumulates a large amount of astaxanthin under various stresses, e.g., blue light and salicylic acid (SA). However, the metabolic response of H. pluvialis to blue light and SA is still unclear. We investigate the effects of blue light and SA on the metabolic response in H. pluvialis using both transcriptomic and proteomic sequencing analyses. The largest numbers of differentially expressed proteins (DEPs; 324) and differentially expressed genes (DEGs; 13,555) were identified on day 2 and day 7 of the treatment with blue light irradiation (150 μmol photons m−2s−1), respectively. With the addition of SA (2.5 mg/L), a total of 63 DEPs and 11,638 DEGs were revealed on day 2 and day 7, respectively. We further analyzed the molecular response in five metabolic pathways related to astaxanthin synthesis, including the astaxanthin synthesis pathway, the fatty acid synthesis pathway, the heme synthesis pathway, the reactive oxygen species (ROS) clearance pathway, and the cell wall biosynthesis pathway. Results show that blue light causes a significant down-regulation of the expression of key genes involved in astaxanthin synthesis and significantly increases the expression of heme oxygenase, which shows decreased expression by the treatment with SA. Our study provides novel insights into the production of astaxanthin by H. pluvialis treated with blue light and SA.
Aromatherapy for Symptom Relief in Patients with Burn: A Systematic Review and Meta-Analysis
Authors: Lee Hye Won , Ang Lin , Kim Jung Tae , Lee Myeong Soo
Published: December 2021

Background and Objectives: This review aimed to provide an updated review of evidence regarding the effects of aromatherapy in relieving symptoms of burn injuries, focusing on pain and physiological distress. Materials and Methods: Fifteen databases (including five English databases, four Korean medical databases, and four Iranian databases) and trial registries were searched for studies published between their dates of inception and July 2021. Two review authors individually performed study selection, data extraction, and risk of bias assessment, and any discrepancies were solved by a third review author. Results: Eight RCTs met our inclusion criteria and were analyzed in this updated systematic review. Our meta-analyses revealed that inhaled aromatherapy plus routine care showed beneficial effects in relieving pain after dressing, as compared to placebo plus routine care (p < 0.00001) and routine care alone (p = 0.02). Additionally, inhaled aromatherapy plus routine care (p < 0.00001) and aromatherapy massage plus routine care (p < 0.0001) also showed superior effects in calming anxiety, as compared to routine care alone. None of the included studies reported on AEs. Overall, the risk of bias across the studies was concerning. Conclusions: This updated review and synthesis of the studies had brought a more detailed understanding of the potential application of aromatherapy for easing the pain and anxiety of burn patients.
Appraisal of Experimental Methods to Manage Menopause and Infertility: Intraovarian Platelet-Rich Plasma vs. Condensed Platelet-Derived Cytokines
Authors: Sills E. , Wood Samuel
Published: December 2021

The first published description of intraovarian platelet-rich plasma (PRP) appeared in mid-2016, when a new experimental technique was successfully used in adult human ovaries to correct the reduced fertility potential accompanying advanced maternal age. Considering the potential therapeutic scope of intraovarian PRP would likely cover both menopause and infertility, the mainstream response has ranged from skeptical disbelief to welcome astonishment. Indeed, reports of intraovarian PRP leading to restored menses in menopause (as an alternative to conventional hormone replacement therapy) and healthy term livebirths for infertility patients (from IVF or as unassisted conceptions) continue to draw notice. Yet, any proper criticism of ovarian PRP applications will be difficult to rebut given the heterogenous patient screening, varied sample preparations, wide differences in platelet incubation and activation protocols, surgical/anesthesia techniques, and delivery methods. Notwithstanding these aspects, no adverse events have thus far been reported and ovarian PRP appears well tolerated by patients. Here, early studies guiding the transition of ‘ovarian rejuvenation’ from experimental to clinical are outlined, with mechanisms to explain results observed in both veterinary and human ovarian PRP research. Current and future challenges for intraovarian cytokine treatment are also discussed.
Development of Data-Driven Machine Learning Models for the Prediction of Casting Surface Defects
Authors: Chen Shikun , Kaufmann Tim
Published: December 2021

This paper presents an approach for the application of machine learning in the prediction and understanding of casting surface related defects. The manner by which production data from a steel and cast iron foundry can be used to create models for predicting casting surface related defect is demonstrated. The data used for the model creation were collected from a medium-sized steel and cast iron foundry in which components ranging from 1 to 100 kg in weight are produced from wear and heat resistant cast iron and steel materials. This includes all production-relevant data from the melting and casting process, as well as from the mold production, the sand preparation and component quality related data from the quality management department. The data are tethered together with each other, the information regarding the identity and number of components that resulted in scrap due to the casting surface defect metal penetrations was added to the dataset. Six different machine learning algorithms were trained and an interpretation of the models outputs was accomplished with the application of the SHAP framework.
Biomimetic Artificial Joints Based on Multi-Material Pneumatic Actuators Developed for Soft Robotic Finger Application
Authors: Zhao Shumi , Lei Yisong , Wang Ziwen , Zhang Jie , Liu Jianxun , Zheng Pengfei , Gong Zidan , Sun Yue
Published: December 2021

To precisely achieve a series of daily finger bending motions, a soft robotic finger corresponding to the anatomical range of each joint was designed in this study with multi-material pneumatic actuators. The actuator as a biomimetic artificial joint was developed on the basis of two composite materials of different shear modules, and the pneumatic bellows as expansion parts was restricted by frame that made from polydimethylsiloxane (PDMS). A simplified mathematical model was used for the bending mechanism description and provides guidance for the multi-material pneumatic actuator fabrication (e.g., stiffness and thickness) and structural design (e.g., cross length and chamber radius), as well as the control parameter optimization (e.g., the air pressure supply). An actuation pressure of over 70 kPa is required by the developed soft robotic finger to provide a full motion range (MCP = 36°, PIP = 114°, and DIP = 75°) for finger action mimicking. In conclusion, a multi-material pneumatic actuator was designed and developed for soft robotic finger application and theoretically and experimentally demonstrated its feasibility in finger action mimicking. This study explored the mechanical properties of the actuator and could provide evidence-based technical parameters for pneumatic robotic finger design and precise control of its dynamic air pressure dosages in mimicking actions. Thereby, the conclusion was supported by the results theoretically and experimentally, which also aligns with our aim to design and develop a multi-material pneumatic actuator as a biomimetic artificial joint for soft robotic finger application.