bluuebunny/crossref_metadata_2025 huggingface dataset:
Revealing the WEDM Process Parameters for the Machining of Pure and Heat-Treated Titanium (Ti-6Al-4V) Alloy
Authors: Gupta Nitin Kumar , Somani Nalin , Prakash Chander , Singh Ranjit , Walia Arminder Singh , Singh Sunpreet , Pruncu Catalin Iulian
Published: April 2021

Ti-6Al-4V is an alloy that has a high strength-to-weight ratio. It is known as an alpha-beta titanium alloy with excellent corrosion resistance. This alloy has a wide range of applications, e.g., in the aerospace and biomedical industries. Examples of alpha stabilizers are aluminum, oxygen, nitrogen, and carbon, which are added to titanium. Examples of beta stabilizers are titanium–iron, titanium–chromium, and titanium–manganese. Despite the exceptional properties, the processing of this titanium alloy is challenging when using conventional methods as it is quite a hard and tough material. Nonconventional methods are required to create intricate and complex geometries, which are difficult with the traditional methods. The present study focused on machining Ti-6Al-4V using wire electrical discharge machining (WEDM) and conducting numerous experiments to establish the machining parameters. The optimal setting of the machining parameters was predicted using a multiresponse optimization technique. Experiments were planned using the response surface methodology (RSM) technique and analysis of variance (ANOVA) was used to determine the significance and contribution of the input parameters to changes in the output characteristics (cutting speed and surface roughness). The cutting speed obtained during the processing of the annealed titanium alloy using WEDM was quite large as compared to the cutting speed obtained in the case of processing the pure, quenched, and hardened titanium alloys using WEDM. The maximum cutting speed obtained while processing the annealed titanium alloy was 1.75 mm/min.
Employing Fuzzy Logic to Analyze the Structure of Complex Biological and Epidemic Spreading Models
Authors: Lefevr Nickie , Kanavos Andreas , Gerogiannis Vassilis C. , Iliadis Lazaros , Pintelas Panagiotis
Published: April 2021

Complex networks constitute a new field of scientific research that is derived from the observation and analysis of real-world networks, for example, biological, computer and social ones. An important subset of complex networks is the biological, which deals with the numerical examination of connections/associations among different nodes, namely interfaces. These interfaces are evolutionary and physiological, where network epidemic models or even neural networks can be considered as representative examples. The investigation of the corresponding biological networks along with the study of human diseases has resulted in an examination of networks regarding medical supplies. This examination aims at a more profound understanding of concrete networks. Fuzzy logic is considered one of the most powerful mathematical tools for dealing with imprecision, uncertainties and partial truth. It was developed to consider partial truth values, between completely true and completely false, and aims to provide robust and low-cost solutions to real-world problems. In this manuscript, we introduce a fuzzy implementation of epidemic models regarding the Human Immunodeficiency Virus (HIV) spreading in a sample of needle drug individuals. Various fuzzy scenarios for a different number of users and different number of HIV test samples per year are analyzed in order for the samples used in the experiments to vary from case to case. To the best of our knowledge, analyzing HIV spreading with fuzzy-based simulation scenarios is a research topic that has not been particularly investigated in the literature. The simulation results of the considered scenarios demonstrate that the existence of fuzziness plays an important role in the model setup process as well as in analyzing the effects of the disease spread.
Resolution Dimension Relative to Resolving Subcategories in Extriangulated Categories
Authors: Tan Lingling , Liu Li
Published: April 2021

Let (C,E,s) be an extriangulated category with a proper class ξ of E-triangles and X a resolving subcategory of C. In this paper, we introduce the notion of X-resolution dimension relative to the subcategory X in C, and then give some descriptions of objects with finite X-resolution dimension. In particular, we obtain Auslander-Buchweitz approximations for these objects. As applications, we construct adjoint pairs for two kinds of inclusion functors, and construct a new resolving subcategory from a given resolving subcategory which reformulates some known results.
Life-Threatening Subglottic Stenosis of Granulomatosis with Polyangiitis: A Case Report
Authors: An Jin , Song Jae-Won
Published: April 2021

Granulomatosis with polyangiitis (GPA) is an autoimmune disease characterized by necrotizing granulomatous inflammation. Subglottic stenosis, which is defined as narrowing of the airway below the vocal cords, has a frequency of 16–23% in GPA. Herein, we present the case of a 39-year-old woman with subglottic stenosis manifesting as life-threatening GPA, which was recurrent under systemic immunosuppressive therapy. The patient underwent an emergency tracheostomy, intratracheal intervention, such as carbon dioxide (CO2) laser surgery and intralesional steroid injection via laryngomicroscopic surgery, and laryngotracheal resection with remodeling. Severe subglottic stenosis treatment requires active intratracheal intervention, surgery, and systemic immunosuppressive therapy.
The Advancement of 7XXX Series Aluminum Alloys for Aircraft Structures: A Review
Authors: Zhou Bo , Liu Bo , Zhang Shengen
Published: April 2021

7XXX series aluminum alloys (Al 7XXX alloys) are widely used in bearing components, such as aircraft frame, spars and stringers, for their high specific strength, high specific stiffness, high toughness, excellent processing, and welding performance. Therefore, Al 7XXX alloys are the most important structural materials in aviation. In this present review, the development tendency and the main applications of Al 7XXX alloys for aircraft structures are introduced, and the existing problems are simply discussed. Also, the heat treatment processes for improving the properties are compared and analyzed. It is the most important measures that optimizing alloy composition and improving heat treatment process are to enhance the comprehensive properties of Al 7XXX alloys. Among the method, solid solution, quenching, and aging of Al 7XXX alloys are the most significant. We introduce the effects of the three methods on the properties, and forecast the development direction of the properties, compositions, and heat treatments and the solution to the corrosion prediction problem for the next generation of Al 7XXX alloys for aircraft structures. The next generation of Al 7XXX alloys should be higher strength, higher toughness, higher damage tolerance, higher hardenability, and better corrosion resistance. It is urgent requirements to develop or invent new heat treatment regime. We should construct a novel corrosion prediction model for Al 7XXX alloys via confirming the surface corrosion environments and selecting the accurate and reliable electrochemical measurements.
Mass Spectrometry-Based Lipidomics Reveals Differential Changes in the Accumulated Lipid Classes in Chronic Kidney Disease
Authors: Marczak Lukasz , Idkowiak Jakub , Tracz Joanna , Stobiecki Maciej , Perek Bartłomiej , Kostka-Jeziorny Katarzyna , Tykarski Andrzej , Wanic-Kossowska Maria , Borowski Marcin , Osuch Marcin , Formanowicz Dorota , Luczak Magdalena
Published: April 2021

Chronic kidney disease (CKD) is characterized by the progressive loss of functional nephrons. Although cardiovascular disease (CVD) complications and atherosclerosis are the leading causes of morbidity and mortality in CKD, the mechanism by which the progression of CVD accelerates remains unclear. To reveal the molecular mechanisms associated with atherosclerosis linked to CKD, we applied a shotgun lipidomics approach fortified with standard laboratory analytical methods and gas chromatography-mass spectrometry technique on selected lipid components and precursors to analyze the plasma lipidome in CKD and classical CVD patients. The MS-based lipidome profiling revealed the upregulation of triacylglycerols in CKD and downregulation of cholesterol/cholesteryl esters, sphingomyelins, phosphatidylcholines, phosphatidylethanolamines and ceramides as compared to CVD group and controls. We have further observed a decreased abundance of seven fatty acids in CKD with strong inter-correlation. In contrast, the level of glycerol was elevated in CKD in comparison to all analyzed groups. Our results revealed the putative existence of a functional causative link—the low cholesterol level correlated with lower estimated glomerular filtration rate and kidney dysfunction that supports the postulated “reverse epidemiology” theory and suggest that the lipidomic background of atherosclerosis-related to CKD is unique and might be associated with other cellular factors, i.e., inflammation.
Virucidal Efficacy of Household Dishwashers
Authors: Lucassen Ralf , Weide Mirko , Bockmühl Dirk
Published: April 2021

Not only since SARS-CoV-2, have transmission routes of viruses been of interest. Noroviruses e.g., can be transmitted via smear infection, are relatively stable in the environment and very resistant to chemical disinfection. Some studies determined the virucidal efficacy of laundering processes, but few studies focused on the virucidal efficacy of dishwashing processes. Here, especially consumer related conditions are of interest. Households for example are a hotspot of norovirus infection and thus a sufficient reduction of these and other viruses from dishes must be insured to avoid an infection via this route. The likelihood of such an event should not be underestimated, since it was shown that the washing machine can be a reservoir for the transmission of extended spectrum beta-lactamase producing bacteria in newborns. Although viruses do not replicate in these devices a transmission via contaminated cutlery e.g., cannot be excluded. Using a consumer related approach to determine the virucidal efficacy of dishwashers, we found a combination of a bleach containing dishwasher detergent, a cleaning temperature of 45 °C for 45 min and a rinsing temperature of 50 °C, to be sufficient to reduces viral titer of bovine corona virus, murine norovirus and modified vaccinia virus by 4.8, 4.2 and 3.8 logarithmic stages respectively.
Antioxidant Activity in Rheum emodi Wall (Himalayan Rhubarb)
Authors: Park Sang Koo , Lee Yoon Kyung
Published: April 2021

Using natural products as antioxidant agents has been beneficial to replace synthetic products. Efforts have been made to profile the antioxidant capacities of natural resources, such as medicinal plants. The polyphenol content of Himalayan rhubarb, Rheum emodi wall, was measured and the antioxidant activity was determined using DPPH and ABTS+ assay, and the oxidative stress was assessed using SOD enzymatic assay. Five different solvent fractions, n-hexane, n-butanol, ethyl acetate, dichloromethane, and water, were used for screening the antioxidant capacity in effort to determine the optimum extraction solvent. The total phenolic contents for R. emodi fractions ranged from 27.76 to 209.21 mg of gallic acid equivalents (GAE)/g of dry weight. DPPH and ABTS+ assay results are presented into IC50 values, ranged from 21.52 to 2448.79 μg/mL and 90.25 to 1718.05 μg/mL, respectively. The ethyl acetate fraction had the highest antioxidant activity among other fractions. Also, n-butanol and water fractions showed significantly lower IC50 values than the positive control in DPPH radical scavenging activity. The IC50 values of SOD assay of fractions ranged from 2.31 to 64.78 μg/mL. A similar result was observed with ethyl acetate fraction showing the highest SOD radical scavenging activity. The study suggests that the ethyl acetate fraction of R. emodi possess the strongest antioxidant activity, thus the most efficient in extracting antioxidant contents. Moreover, a highly significant correlation was shown between total polyphenol content and antioxidant activity screening assays. The compounds related to the antioxidant activity of R. emodi were identified to myricitrin, myricetin 3-galloyl rhamnoside, and myricetin, which have not been reported in studies about R. emodi before.
Enhancement of Volumetric Capacitance of Binder-Free Single-Walled Carbon Nanotube Film via Fluorination
Authors: Gurova Olga A. , Sysoev Vitalii I. , Lobiak Egor V. , Makarova Anna A. , Asanov Igor P. , Okotrub Alexander V. , Kulik Leonid V. , Bulusheva Lyubov G.
Published: April 2021

Robust electrode materials without the addition of binders allow increasing efficiency of electrical storage devices. We demonstrate the fabrication of binder-free electrodes from modified single-walled carbon nanotubes (SWCNTs) for electrochemical double-layer capacitors (EDLCs). Modification of SWCNTs included a sonication in 1,2-dichlorobenzene and/or fluorination with gaseous BrF3 at room temperature. The sonication caused the shortening of SWCNTs and the splitting of their bundles. As a result, the film prepared from such SWCNTs had a higher density and attached a larger amount of fluorine as compared to the film from non-sonicated SWCNTs. In EDLCs with 1M H2SO4 electrolyte, the fluorinated films were gradually defluorinated, which lead to an increase of the specific capacitance by 2.5–4 times in comparison with the initial values. Although the highest gravimetric capacitance (29 F g−1 at 100 mV s−1) was observed for the binder-free film from non-modified SWCNT, the fluorinated film from the sonicated SWCNTs had an enhanced volumetric capacitance (44 F cm−3 at 100 mV s−1). Initial SWCNT films and defluorinated films showed stable work in EDLCs during several thousand cycles.
Changes in Plasma Metabolome Profiles Following Oral Glucose Challenge among Adult Chinese
Authors: Huo Shaofeng , Sun Liang , Zong Geng , Shen Xia , Zheng He , Jin Qianlu , Li Huaixing , Yin Huiyong , Lin Xu
Published: April 2021

Little is known about changes in plasma metabolome profiles during the oral glucose tolerance test (OGTT) in Chinese. We aimed to characterize plasma metabolomic profiles at 0 and 2 h of OGTT and their changes in individuals of different glycemic statuses. A total of 544 metabolites were detected at 0 and 2 h of OGTT by a nontarget strategy in subjects with normal glucose (n = 234), prediabetes (n = 281), and newly diagnosed type 2 diabetes (T2D) (n = 66). Regression model, mixed model, and partial least squares discrimination analysis were applied. Compared with subjects of normal glucose, T2D cases had significantly higher levels of glycerone at 0 h and 22 metabolites at 2 h of OGTT (false discovery rate (FDR) < 0.05, variable importance in projection (VIP) > 1). Seven of the twenty-two metabolites were also significantly higher in T2D than in prediabetes subjects at 2 h of OGTT (FDR < 0.05, VIP > 1). Two hours after glucose challenge, concentrations of 35 metabolites (normal: 18; prediabetes: 23; T2D: 13) significantly increased (FDR < 0.05, VIP > 1, fold change (FC) > 1.2), whereas those of 45 metabolites (normal: 36; prediabetes: 29; T2D: 18) significantly decreased (FDR < 0.05, VIP > 1, FC < 0.8). Distinct responses between cases and noncases were detected in metabolites including 4-imidazolone-5-acetate and 4-methylene-L-glutamine. More varieties of distinct metabolites across glycemic statuses were observed at 2 h of OGTT compared with fasting state. Whether the different patterns and responsiveness of certain metabolites in T2D reflect a poor resilience of specific metabolic pathways in regaining glucose homeostasis merits further study.
Effect of Multi-Strain Probiotic Supplementation on URTI Symptoms and Cytokine Production by Monocytes after a Marathon Race: A Randomized, Double-Blind, Placebo Study
Authors: Tavares-Silva Edgar , Caris Aline Venticinque , Santos Samile Amorin , Ravacci Graziela Rosa , Thomatieli-Santos Ronaldo Vagner
Published: April 2021

(1) Purpose: Performing strenuous exercises negatively impacts the immune and gastrointestinal systems. These alterations cause transient immunodepression, increasing the risk of minor infections, especially in the upper respiratory tract. Recent studies have shown that supplementation of probiotics confers benefits to athletes. Therefore, the objective of the current study was to verify the effects of probiotic supplementation on cytokine production by monocytes and infections in the upper respiratory tract after an acute strenuous exercise. (2) Methods: Fourteen healthy male marathon runners received either 5 billion colony forming units (CFU) of a multi-strain probiotic, consisting of 1 billion CFU of each of Lactobacillus acidophilus LB-G80, Lactobacillus paracasei LPc-G110, Lactococcus subp. lactis LLL-G25, Bifidobacterium animalis subp. lactis BL-G101, and Bifidobacterium bifidum BB-G90, or a placebo for 30 days before a marathon. Plasma cytokines, salivary parameters, glucose, and glutamine were measured at baseline, 24 h before, immediately after, and 1 h after the race. Subjects self-reported upper respiratory tract infection (URTI) using the Wisconsin Upper Respiratory Symptom Survey (WURSS—21). The statistical analyses comprised the general linear model (GLM) test followed by the Tukey post hoc and Student’s t-test with p < 0.05. (3) Results: URTI symptoms were significantly lower in the probiotic group compared to placebo. The IL-2 and IL-4 plasma cytokines were lower 24 h before exercise, while the other cytokines showed no significant differences. A lower level of IL-6 produced by monocytes was verified immediately after the race and higher IL-10 at 1 h post. No differences were observed in salivary parameters. Conclusion: Despite the low number of marathoners participating in the study, probiotic supplementation suggests its capability to preserve the functionality of monocytes and mitigate the incidence of URTI.
Dietary Patterns Derived from UK Supermarket Transaction Data with Nutrient and Socioeconomic Profiles
Authors: Clark Stephen D. , Shute Becky , Jenneson Victoria , Rains Tim , Birkin Mark , Morris Michelle A.
Published: April 2021

Poor diet is a leading cause of death in the United Kingdom (UK) and around the world. Methods to collect quality dietary information at scale for population research are time consuming, expensive and biased. Novel data sources offer potential to overcome these challenges and better understand population dietary patterns. In this research we will use 12 months of supermarket sales transaction data, from 2016, for primary shoppers residing in the Yorkshire and Humber region of the UK (n = 299,260), to identify dietary patterns and profile these according to their nutrient composition and the sociodemographic characteristics of the consumer purchasing with these patterns. Results identified seven dietary purchase patterns that we named: Fruity; Meat alternatives; Carnivores; Hydrators; Afternoon tea; Beer and wine lovers; and Sweet tooth. On average the daily energy intake of loyalty card holders -who may buy as an individual or for a household- is less than the adult reference intake, but this varies according to dietary purchase pattern. In general loyalty card holders meet the recommended salt intake, do not purchase enough carbohydrates, and purchase too much fat and protein, but not enough fibre. The dietary purchase pattern containing the highest amount of fibre (as an indicator of healthiness) is bought by the least deprived customers and the pattern with lowest fibre by the most deprived. In conclusion, supermarket sales data offer significant potential for understanding population dietary patterns.
Cytokine, Chemokine, and Metalloprotease Activation in the Serum of Patients with Nephropathia Epidemica from the Republic of Tatarstan and the Republic of Mordovia, Russia
Authors: Martynova Ekaterina , Davidyuk Yuriy , Kabwe Emmanuel , Garanina Ekaterina E. , Shakirova Venera , Pavelkina Vera , Uskova Yulia , Stott Robert J. , Foster Toshana L. , Markelova Maria , Goyal Mehendi , Gupta Abhimat , Bhola Mannan , Kumar Vinay , Baranwal Manoj , Rizvanov Albert A. , Khaiboullina Svetlana F.
Published: April 2021

Nephropathia Epidemica (NE), endemic to several Volga regions of Russia, including the Republic of Tatarstan (RT) and the Republic of Mordovia (RM), is a mild form of hemorrhagic fever with renal syndrome caused by infection with rodent-borne orthohantaviruses. Although NE cases have been reported for decades, little is known about the hantavirus strains associated with human infection in these regions. There is also limited understanding of the pathogenesis of NE in the RT and the RM. To address these knowledge gaps, we conducted comparative analyses of patients with NE in the RT and the RM. Clinical symptoms were more severe in patients with NE from the RM with longer observed duration of fever symptoms and hospitalization. Analysis of patient sera showed changes in the levels of numerous cytokines, chemokines, and matrix metalloproteases (MMPs) in patients with NE from both the RT and the RM, suggesting leukocyte activation, extracellular matrix degradation, and leukocyte chemotaxis. Interestingly, levels of several cytokines were distinctly different between patients NE from the RT when compared with those from the RM. These differences were not related to the genetic variation of orthohantaviruses circulating in those regions, as sequence analysis showed that Puumala virus (PUUV) was the causative agent of NE in these regions. Additionally, only the “Russia” (RUS) genetic lineage of PUUV was detected in the serum samples of patients with NE from both the RT and the RM. We therefore conclude that differences in serum cytokine, chemokine, and MMP levels between the RT and the RM are related to environmental factors and lifestyle differences that influence individual immune responses to orthohantavirus infection.
Unique Attributes of the Laurel Wilt Fungal Pathogen, Raffaelea lauricola, as Revealed by Metabolic Profiling
Authors: Joseph Ross , Lasa Michelle , Zhou Yonghong , Keyhani Nemat O.
Published: April 2021

Raffaelea lauricola is the causative agent of laurel wilt, a devastating disease of lauraceous trees. R. lauricola is also an obligate nutritional symbiont of several ambrosia beetle species who act as vectors for the pathogen. Here, we sought to establish the baseline “phenome” of R. lauricola with knowledge concerning its metabolic capability, expanding our understanding of how these processes are impacted by environmental and host nutrients. Phenotypic screening using a microarray of over one thousand compounds was used to generate a detailed profile of R. lauricola substrate utilization and chemical sensitivity. These data revealed (i) relatively restricted carbon utilization, (ii) broad sulfur and phosphate utilization, and (iii) pH and osmotic sensitivities that could be rescued by specific compounds. Additional growth profiling on fatty acids revealed toxicity on C10 substrates and lower, with robust growth on C12–C18 fatty acids. Conditions for lipid droplet (LD) visualization and LD dynamics were examined using a series of lipid dyes. These data provide unique insights regarding R. lauricola metabolism and physiology, and identify distinct patterns of substrate usage and sensitivity which likely reflect important aspects of the host-microbe interface and can be exploited for the development of strategies for mitigating the spread of laurel wilt.
Genomic Characterization of Salmonella typhimurium DT104 Strains Associated with Cattle and Beef Products
Authors: Parker Craig T. , Huynh Steven , Alexander Aaron , Oliver Andrew S. , Cooper Kerry K.
Published: April 2021

Salmonella enterica subsp. enterica serovar Typhimurium DT104, a multidrug-resistant phage type, has emerged globally as a major cause of foodborne outbreaks particularly associated with contaminated beef products. In this study, we sequenced three S. Typhimurium DT104 strains associated with a 2009 outbreak caused by ground beef, including the outbreak source strain and two clinical strains. The goal of the study was to gain a stronger understanding of the genomics and genomic epidemiology of highly clonal S. typhimurium DT104 strains associated with bovine sources. Our study found no single nucleotide polymorphisms (SNPs) between the ground beef source strain and the clinical isolates from the 2009 outbreak. SNP analysis including twelve other S. typhimurium strains from bovine and clinical sources, including both DT104 and non-DT104, determined DT104 strains averaged 55.0 SNPs between strains compared to 474.5 SNPs among non-DT104 strains. Phylogenetic analysis separated the DT104 strains from the non-DT104 strains, but strains did not cluster together based on source of isolation even within the DT104 phage type. Pangenome analysis of the strains confirmed previous studies showing that DT104 strains are missing the genes for the allantoin utilization pathway, but this study confirmed that the genes were part of a deletion event and not substituted or disrupted by the insertion of another genomic element. Additionally, cgMLST analysis revealed that DT104 strains with cattle as the source of isolation were quite diverse as a group and did not cluster together, even among strains from the same country. Expansion of the analysis to 775 S. typhimurium ST19 strains associated with cattle from North America revealed diversity between strains, not limited to just among DT104 strains, which suggests that the cattle environment is favorable for a diverse group of S. typhimurium strains and not just DT104 strains.
Study of Cytotoxic and Photodynamic Activities of Dyads Composed of a Zinc Phthalocyanine Appended to an Organotin
Authors: Toubia Isabelle , Nguyen Christophe , Diring Stéphane , Pays Marine , Mattana Elodie , Arnoux Philippe , Frochot Céline , Gary-Bobo Magali , Kobeissi Marwan , Odobel Fabrice
Published: April 2021

The combination of photodynamic therapy and chemotherapy is a promising strategy to enhance cancer therapeutic efficacy and reduce drug resistance. In this study two zinc(II) phthalocyanine-tin(IV) conjugates linked by a triethylene glycol chain were synthesized and characterized. In these complexes, the zinc(II) phthalocyanine was used as a potential photosensitizer for PDT and the tin complex was selected as cytostatic moiety. The two dyads composed of zinc(II) phthalocyanine and tin complexes exhibited high cytotoxicity, in absence of light stimulation, against MCF-7 human breast cancer cells with low LC50 values in the range of 0.016–0.453 µM. In addition, these complexes showed superior cytotoxicity than their mixture of equimolar component, accompanied with a higher activity towards cancer cells compared to human healthy fibroblasts. However, under irradiation of the zinc phthalocyanine unit (at 650 nm) no photodynamic activity could be detected, due to the most likely quenching of zinc(II) phthalocyanine singlet excited state by the nearby tin complex according to a photoinduced electron transfer process. This study demonstrates the potential of heterometallic anticancer chemotherapeutics composed of a zinc phthalocyanine and tin complex, and it highlights that the development of such conjugates requires that the sensitizer preserves its photophysical properties and in particular its singlet oxygen sensitization ability in the conjugate in order to combine the PDT activity with the cytotoxicity of the anticancer drug.
Intercropping of Peanut–Tea Enhances Soil Enzymatic Activity and Soil Nutrient Status at Different Soil Profiles in Subtropical Southern China
Authors: Farooq Taimoor Hassan , Kumar Uttam , Mo Jing , Shakoor Awais , Wang Jun , Rashid Muhammad Haroon U. , Tufail Muhammad Aammar , Chen Xiaoyong , Yan Wende
Published: April 2021

Intercropping is one of the most widely used agroforestry techniques, reducing the harmful impacts of external inputs such as fertilizers. It also controls soil erosion, increases soil nutrients availability, and reduces weed growth. In this study, the intercropping of peanut (Arachishypogaea L.) was done with tea plants (Camellia oleifera), and it was compared with the mono-cropping of tea and peanut. Soil health and fertility were examined by analyzing the variability in soil enzymatic activity and soil nutrients availability at different soil depths (0–10 cm, 10–20 cm, 20–30 cm, and 30–40 cm). Results showed that the peanut–tea intercropping considerably impacted the soil organic carbon (SOC), soil nutrient availability, and soil enzymatic responses at different soil depths. The activity of protease, sucrase, and acid phosphatase was higher in intercropping, while the activity of urease and catalase was higher in peanut monoculture. In intercropping, total phosphorus (TP) was 14.2%, 34.2%, 77.7%, 61.9%; total potassium (TK) was 13.4%, 20%, 27.4%, 20%; available phosphorus (AP) was 52.9%, 26.56%, 61.1%; 146.15% and available potassium (AK) was 11.1%, 43.06%, 46.79% higher than the mono-cropping of tea in respective soil layers. Additionally, available nitrogen (AN) was 51.78%, 5.92%, and 15.32% lower in the 10–20 cm, 20–30 cm, and 30–40 cm layers of the intercropping system than in the mono-cropping system of peanut. Moreover, the soil enzymatic activity was significantly correlated with SOC and total nitrogen (TN) content across all soil depths and cropping systems. The depth and path analysis effect revealed that SOC directly affected sucrase, protease, urease, and catalase enzymes in an intercropping system. It was concluded that an increase in the soil enzymatic activity in the intercropping pattern improved the reaction rate at which organic matter decomposed and released nutrients into the soil environment. Enzyme activity in the decomposition process plays a vital role in forest soil morphology and function. For efficient land use in the cropping system, it is necessary to develop coherent agroforestry practices. The results in this study revealed that intercropping certainly enhance soil nutrients status and positively impacts soil conservation.
Comparative Study of the Influence of Bio-Resin Color on the Dimension, Flatness and Straightness of the Part in the 3D Printing Process
Authors: Tulcan Aurel , Vasilescu Mircea Dorin , Tulcan Liliana
Published: April 2021

This paper aims to determine whether the color of based-plant resin called, by the manufacturer, eco-resin has an influence on the dimensions and geometric accuracy of the 3D-printed part. The analysis of flatness, straightness and dimensions deviations was carried out with high-precision measurement systems, and according to current standards regarding linear dimensions and geometrical tolerances. A coordinate measuring machine with contact probes was used to measure the printed part’s physical characteristics, and analysis of variance and response surface design methods were used for the data analysis. The printing experiment was carried out for each color. After that, the measurement of the printed parts and the study of the data were performed. The first finding is that for black and clear eco-resin, there are problems with the printing of the supports. Based on standard data for the range of nominal lengths of the part for linear dimensions, flatness and straightness, the measurement results can be included in different tolerance classes within standard value limits. The best value of the printed structure was obtained for clear eco-resin. The paper demonstrates that the impact of the color of the eco-resin is more important than the supports density for all the studied features. Based on 3D measurements, the optimal values for each of the eco-resin colors regarding the flatness, straightness and linear dimensions deviations of the 3D printed part were also determined.
Glycolysis of Polyurethanes Composites Containing Nanosilica
Authors: del Amo Jesus , Borreguero Ana Maria , Ramos Maria Jesus , Rodríguez Juan Francisco
Published: April 2021

Rigid polyurethane (RPU) foams have been successfully glycolyzed by using diethylene glycol (DEG) and crude glycerol (CG) as transesterification agents. However, DEG did not allow to achieve a split-phase process, obtaining a product with low polyol purity (61.7 wt %). On contrary, CG allowed to achieve a split-phase glycolysis improving the recovered polyol purity (76.5%). This is an important novelty since, up to now, RPUs were glycolyzed in single-phase processes giving products of low polyol concentration, which reduced the further applications. Moreover, the nanosilica used as filler of the glycolyzed foams was recovered completely pure. The recovered polyol successfully replaced up to 60% of the raw polyol in the synthesis of RPU foams and including the recovered nanosilica in the same concentration than in glycolyzed foam. Thus, the feasibility of the chemical recycling of this type of polyurethane composites has been demonstrated. Additionally, PU foams were synthesized employing fresh nanosilica to evaluate whether the recovered nanosilica has any influence on the RPU foam properties. These foams were characterized structurally, mechanically and thermally with the aim of proving that they met the specifications of commercial foams. Finally, the feasibility of recovering the of CG by vacuum distillation has been demonstrated.
Combining Mass Spectrometry-Based Phosphoproteomics with a Network-Based Approach to Reveal FLT3-Dependent Mechanisms of Chemoresistance
Authors: Pugliese Giusj Monia , Latini Sara , Massacci Giorgia , Perfetto Livia , Sacco Francesca
Published: April 2021

FLT3 mutations are the most frequently identified genetic alterations in acute myeloid leukemia (AML) and are associated with poor clinical outcome, relapse and chemotherapeutic resistance. Elucidating the molecular mechanisms underlying FLT3-dependent pathogenesis and drug resistance is a crucial goal of biomedical research. Given the complexity and intricacy of protein signaling networks, deciphering the molecular basis of FLT3-driven drug resistance requires a systems approach. Here we discuss how the recent advances in mass spectrometry (MS)-based (phospho) proteomics and multiparametric analysis accompanied by emerging computational approaches offer a platform to obtain and systematically analyze cell-specific signaling networks and to identify new potential therapeutic targets.
The ABC of Deutsch–Hayden Descriptors
Authors: Bédard Charles
Published: April 2021

It has been more than 20 years since Deutsch and Hayden proved the locality of quantum theory, using the Heisenberg picture of quantum computational networks. Of course, locality holds even in the face of entanglement and Bell’s theorem. Today, most researchers in quantum foundations are still convinced not only that a local description of quantum systems has not yet been provided, but that it cannot exist. The main goal of this paper is to address this misconception by re-explaining the descriptor formalism in a hopefully accessible and self-contained way. It is a step-by-step guide to how and why descriptors work. Finally, superdense coding is revisited in the light of descriptors.
Condition Assessment for Concrete Sewer Pipes Using Displacement Probes: A Robotic Design Case Study
Authors: Ross Robert , Stumpf Alex , Barnett Dean , Hall Richard
Published: April 2021

Worldwide, millions of kilometres of sewers are constructed from concrete pipes. Unfortunately, concrete sewers are susceptible to corrosion from biogenic hydrogen sulphide, and, though they may pass visual inspection, their ability to hold together under load may be degraded. This paper presents the design of a teleoperated robot with a protractible probe, that allows an operator to apply a localised load to selected points within a concrete sewer pipe. We report findings from laboratory and field trials of our prototype, with initial results suggesting that this approach has the potential to contribute useful information to sewer maintenance planning.
A 4-Year Climatological Analysis Based on GPM Observations of Deep Convective Events in the Mediterranean Region
Authors: Hourngir Dario , Panegrossi Giulia , Casella Daniele , Sanò Paolo , D’Adderio Leo Pio , Liu Chuntao
Published: April 2021

Since early March 2014, the NASA/JAXA Global Precipitation Measurement Core- Observatory (GPM-CO) satellite has allowed analysis of precipitation systems around the globe, thanks to the capabilities of the GPM Microwave Imager (GMI) and Dual-Frequency Precipitation Radar (DPR). In this work, we demonstrate how GPM-CO measurements obtained from 4 years of observations over the Mediterranean area can be used as an extremely effective tool to study the main climatological characteristics of the most intense Mediterranean storm structures. DPR and GMI-based Precipitation Features (PFs) parameters are used as proxies of the vertical structure and microphysical properties of these events, and their statistical distribution is analyzed to identify extremes. The analysis of annual, seasonal and geographical distribution of the identified deep convective systems highlights substantial differences in their diurnal cycle and in the distribution between land-sea and summer-winter. There is a general shift of the convective systems from the south (mostly over the sea) in the cold season, to the north (mostly over land) in the warm season. The analysis shows also that the inferred convective intensity is not always related to heavy precipitation. Known DPR and GMI-based criteria were adopted to identify overshooting top events and potential hailstorms, identify extreme deep convection signatures, like those observed for tropical and subtropical systems, and the most intense occur mostly over the sea. Although the analysis is limited to four years, the results show that the GPM-CO offers unprecedented measurements to identify and characterize extreme weather events in the Mediterranean region, with unique potentials for future long-term climatology and interannual variability analysis.
3D Reconstruction and Geostatic Analysis of an Early Medieval Cemetery (Olonne-sur-Mer, France)
Authors: Colleter Rozenn , Barreau Jean-Baptiste
Published: April 2021

A preventive excavation performed in 2018 prior to development work led to the discovery of more than 213 subjects buried from the 4th to the 11th centuries in the 1850 m2 dug area. This is a cemetery located in Olonne-sur-Mer in France (46.53723, −1.77603). The complex is limited to the south by a ditch. To the north, no limits were observed during the excavation and, to the west, ancient archaeological surveys suggest an extension of the burial area. Biological analysis of the skeletons reveals a demographic characterizing a natural community, with an under-representation of children under 5 and with subjects under 20 appearing to be grouped together in the center of the area. The place where the youngest are buried often testifies to a strategic position in Christian contexts (near church doors, under sub stillicidio gutters, etc.). Funeral practices are characterized by numerous skeletal alterations, especially in the western area of the site where their concentrations are particularly significant. These are not ossuaries but rather supernumerary bones present in the fills of graves of subjects in place or old tombs where no skeletons in place are preserved. These alterations mark the areas where burials are most frequent. The 3D reconstruction is coupled with geostatistical analyses (heatmap and Moran’s index), considering the digging of the land, the concentration of residual artefacts found in the graves, but also the biological characteristics of the sample and the funeral practices uncovered. From 2D entities generated with GIS software, the process of the elevation and sculpture of the volumes is innovative, because even if it is carried out by precise but classical computer graphics techniques, it is led by advanced taphonomical and anthropological reflections. This makes it possible to propose empty spaces, a potential gathering area for the village community and circulation paths. These elements are essential in order to go beyond the storytelling often proposed in archaeology and propose a vision based on the coherence of the observed facts. Even when the archaeological remains are only sunken (no preserved elevation), the integration of multisource archaeological data (biological anthropology, funerary, artefacts and pit size) allows relevant 3D reconstructions as a formidable tool for discussing past occupations. Three-dimensional technologies make it possible to recreate a lost environment to allow a better understanding of the site. They are didactic and help to share data between researchers and/or the public, especially when they are invisible such as the presence of empty space.
Investigating the Potential of a Newly Developed UAV-Mounted VNIR/SWIR Imaging System for Monitoring Crop Traits—A Case Study for Winter Wheat
Authors: Jenal Alexander , Hüging Hubert , Ahrends Hella Ellen , Bolten Andreas , Bongartz Jens , Bareth Georg
Published: April 2021

UAV-based multispectral multi-camera systems are widely used in scientific research for non-destructive crop traits estimation to optimize agricultural management decisions. These systems typically provide data from the visible and near-infrared (VNIR) domain. However, several key absorption features related to biomass and nitrogen (N) are located in the short-wave infrared (SWIR) domain. Therefore, this study investigates a novel multi-camera system prototype that addresses this spectral gap with a sensitivity from 600 to 1700 nm by implementing dedicated bandpass filter combinations to derive application-specific vegetation indices (VIs). In this study, two VIs, GnyLi and NRI, were applied using data obtained on a single observation date at a winter wheat field experiment located in Germany. Ground truth data were destructively sampled for the entire growing season. Likewise, crop heights were derived from UAV-based RGB image data using an improved approach developed within this study. Based on these variables, regression models were derived to estimate fresh and dry biomass, crop moisture, N concentration, and N uptake. The relationships between the NIR/SWIR-based VIs and the estimated crop traits were successfully evaluated (R2: 0.57 to 0.66). Both VIs were further validated against the sampled ground truth data (R2: 0.75 to 0.84). These results indicate the imaging system’s potential for monitoring crop traits in agricultural applications, but further multitemporal validations are needed.
Twitch as a Techno-Pedagogical Resource to Complement the Flipped Learning Methodology in a Time of Academic Uncertainty
Authors: Pozo-Sánchez Santiago , López-Belmonte Jesús , Fuentes-Cabrera Arturo , López-Núñez Juan-Antonio
Published: April 2021

Flipped learning methodology has the potential to be combined with a multitude of didactic actions and techno-pedagogical resources that are adapted to the needs of the student. Access to resources and training outside the classroom can be carried out from various platforms. Following this line, Twitch is an interactive video transmission platform that is presented as an interesting digital resource to enhance the motivation of students in turning over learning moments. The objective of the study is to analyze the motivation of students in two different methodological approaches, one traditional and the other innovative through the Twitch application. A quasi-experimental pre-post design was carried out. A total of 52 Spanish students from the fourth level of secondary education participated in the research. Data collection was carried out by adapting the Motivated Strategies for Learning Questionnaire (MSLQ) instrument to the Spanish context. The results reflect higher levels of motivation in the implementation of Twitch with respect to its materialization without using said techno-pedagogical complement. This difference is especially significant in intrinsic motivation, since in the case of extrinsic motivation, the difference between both pedagogical proposals is smaller. In short, the implementation of Twitch in the flipped learning supposes an optimization of this pedagogical methodology, increasing the extrinsic and intrinsic motivation of the students and modifying the centers of interest of students from quantitative aspects to other, qualitative ones.
Intelligent Urban Planning and Ecological Urbanscape-Solutions for Sustainable Urban Development. Case Study of Wolfsburg
Authors: Dudek-Klimiuk Joanna , Warzecha Barbara
Published: April 2021

Intelligent urban planning and ecological urbanism can be recognized as two of the key solutions to act against urban sprawl. This process is associated with suburbanization, blurring boundaries between the city and suburbs, and the undefined role of open and green spaces within new structures. It has been identified as the biggest and the most common problem worldwide. This non-central planning has a huge impact not only on economic aspects, but—most of all—on the ecological and landscaping balance within the urban area. This study covers not only the recognition of the outlined situation, but also a conceptual proposal to challenge the problems of urban sprawl. The city of Wolfsburg serves as a case study to which the tools of Ecological Urbanism and Intelligent Urbanism were applied. A corrective plan for the study area has been worked out, based on the main approaches in urban planning of the 21st century. The green transformation processes to achieve resiliency within urban areas are inevitable and will have to be conducted due to the rising number of the dwellers, steadily changing climate, and socio-economic conditions all over the world. The main solutions include mainly the system of green corridors, interconnectedness of open spaces, walkability with smart mobile options and social community as a nucleus of a local neighborhood.
Higher Education Teachers’ Training in Attention to SEN Students: Testing a Mediation Model
Authors: González-Castellano Nuria , Cordón-Pozo Eulogio , Pueyo-Villa Silvia , Colmenero-Ruiz María Jesús
Published: April 2021

There is growing interest in analyzing the evolution of inclusive education in universities, highlighting the training of teachers as the main barrier to this evolution. The purpose of this study was to analyze, through a mediation model, to what extent the accessibility and inclusion of university campuses affect, both directly and indirectly, the continuous training of teachers in attention to diversity and training demands by teachers in this same area. Participants were 580 teachers from the Faculty of Education of eight Andalusian universities (Spain). The results revealed that the continuous training of teachers in attention to diversity mediates the negative effect that accessibility and inclusion of university campuses have on the training demanded by teachers; this means that the more accessible and inclusive the universities are, the more continuous training teachers have and therefore the more interest they have in continuing training. There is no empirical evidence in the literature that this mediation model is used in the field of educational inclusion as a methodological technique, so it is a very innovative contribution.