bluuebunny/crossref_metadata_2025 huggingface dataset:
Cooling to Facilitate Metabolic Suppression in Healthy Individuals
Authors: Rittenberger Jon C. , Flickinger Kathryn L. , Weissman Alexandra , Repine Melissa , Elmer Jonathan , Guyette Francis X. , Callaway Clifton W.
Published: April 2019

BACKGROUND: Carbon dioxide (CO2) toxicity could be catastrophic for astronauts. Suppressing metabolism by lowering body temperature decreases CO2 production and may facilitate rescue in the event of a crippled ship. Lowering body temperature requires shivering
suppression. We evaluated dexmedetomidine to facilitate cooling of healthy individuals.METHODS: Following consent, we administered a 1 mcg · kg−1 bolus of dexmedetomidine followed by continuous infusion (0.5–1.4 mcg · kg−1 ·
h−1) for 3 h of cooling. We cooled subjects using a bolus of 30 cc · kg−1 of 4°C saline followed by surface cooling. We measured vital signs, thermal and comfort scales, sedation, and shivering for 3 h and during recovery. ANOVA evaluated changes
in measures over time.RESULTS: Nine subjects completed the study. Mean age was 31 (SD 8) yr, mean mass was 71 (SD 14) kg, height of 168 (SD 9) cm, and body mass index of 25 (SD 3). Median time to 1°C drop in core temperature was 16 (IQR 15, 32) min. Temperature changed over
time with median lowest temperature being 33.1°C (IQR 32.8°C, 34.1°C). Neither heart rate nor diastolic blood pressures changed over time. Systolic blood pressure decreased over time. Subjects responded to verbal stimuli and completed tasks throughout the protocol. During cooling
and maintenance, subjects reported discomfort and the sensation of being cold.CONCLUSION: Dexmedetomidine facilitates shivering suppression during prolonged cooling in healthy individuals. Subjects are easily roused, have mild decreases in systolic blood pressure, and note sensations
of discomfort and cold. Cooling to suppress metabolism is a feasible countermeasure to prolong astronaut endurance.Rittenberger JC, Flickinger KL, Weissman A, Repine M, Elmer J, Guyette FX, Callaway CW. Cooling to facilitate metabolic suppression in healthy individuals. Aerosp
Med Hum Perform. 2019; 90(5):475–479.
The Preparation of Hollow Mesoporous Bioglass Nanoparticles With Excellent Drug Delivery Capacity for Bone Tissue Regeneration
Authors: Wang Yudong , Pan Haobo , Chen Xiaofeng
Published: April 2019

In this work, hollow mesoporous bioglass (HMBG) nanoparticles were prepared in a hexadecyl trimethyl ammonium bromide (CTAB)-cyclonexane-ethanol-water (O/W) emulsion system. The HMBG nanoparticles possessed higher drug storage ability and stable drug release behavior which resulted from HMBG's unique mesoporous structure. The mesoporous structure could be modulated by adjusting the concentration of CTAB. The specific surface area and drug loading efficiency was as high as 749.619 m2g−1 and 55.1%. Besides, in vivo experiments demonstrated that the HMBG nanoparticles could promote the bone tissue regeneration and the drug-loading HMBG nanoparticles possessed better repair capability. The unique structure and properties might make the HMBG nanoparticles good candidates as drug carriers and repair materials for bone tissue regeneration.
Research on a Mixed Gas Classification Algorithm Based on Extreme Random Tree
Authors: Xu Yonghui , Zhao Xi , Chen Yinsheng , Yang Zixuan
Published: April 2019

Because of the low accuracy of the current machine olfactory algorithms in detecting two mixed gases, this study proposes a hybrid gas detection algorithm based on an extreme random tree to greatly improve the classification accuracy and time efficiency. The method mainly uses the dynamic time warping algorithm (DTW) to perform data pre-processing and then extracts the gas characteristics from gas signals at different concentrations by applying a principal component analysis (PCA). Finally, the model is established by using a new extreme random tree algorithm to achieve the target gas classification. The sample data collected by the experiment was verified by comparison experiments with the proposed algorithm. The analysis results show that the proposed DTW algorithm improves the gas classification accuracy by 26.87%. Compared with the random forest algorithm, extreme gradient boosting (XGBoost) algorithm and gradient boosting decision tree (GBDT) algorithm, the accuracy rate increased by 4.53%, 5.11% and 8.10%, respectively, reaching 99.28%. In terms of the time efficiency of the algorithms, the actual runtime of the extreme random tree algorithm is 66.85%, 90.27%, and 81.61% lower than that of the random forest algorithm, XGBoost algorithm, and GBDT algorithm, respectively, reaching 103.2568 s.
Wood Chip Drying through the Using of a Mobile Rotary Dryer
Authors: Del Giudice Angelo , Acampora Andrea , Santangelo Enrico , Pari Luigi , Bergonzoli Simone , Guerriero Ettore , Petracchini Francesco , Torre Marco , Paolini Valerio , Gallucci Francesco
Published: April 2019

Drying is a critical point for the exploitation of biomass for energy production. High moisture content negatively affects the efficiency of power generation in combustion and gasification systems. Different types of dryers are available however; it is known that rotary dryers have low cost of maintenance and consume 15% and 30% less in terms of specific energy. The study analyzed the drying process of woody residues using a new prototype of mobile rotary dryer cocurrent flow. Woodchip of poplar (Populus spp.), black locust (Robinia pseudoacacia L.), and grapevine (Vitis vinifera L.) pruning were dried in a rotary drier. The drying cycle lasted 8 h for poplar, 6 h for black locust, and 6 h for pruning of grapevine. The initial biomass had a moisture content of around 50% for the poplar and around 30% for grapevine and black locust. The study showed that some characteristics of the biomass (e.g., initial moisture content, particle size distribution, bulk density) influence the technical parameters (i.e., airflow temperature, rate, and speed) of the drying process and, hence, the energy demand. At the end of the drying process, 17% of water was removed for poplar wood chips and 31% for grapevine and black locust wood chips. To achieve this, result the three-biomass required 1.61 (poplar), 0.86 (grapevine), and 1.12 MJ kgdry solids−1 (black locust), with an efficiency of thermal drying (η) respectively of 37%, 12%, and 27%. In the future, the results obtained suggest an increase in the efficiency of the thermal insulation of the mobile dryer, and the application of the mobile dryer in a small farm, for the recovery of exhaust gases from thermal power plants.
Real-Time Implementation of a Super Twisting Algorithm for PEM Fuel Cell Power System
Authors: Derbeli Mohamed , Barambones Oscar , Ramos-Hernanz Jose Antonio , Sbita Lassaad
Published: April 2019

Proton exchange membrane fuel cell (PEMFC) topology is becoming one of the most reliable and promising alternative resource of energy for a wide range of applications. However, efficiency improvement and lifespan extension are needed to overcome the limited market of fuel cell technologies. In this paper, an efficient approach based on a super-twising algorithm (STA) is proposed for the PEMFC system. The control objective is to lengthen the fuel cell lifetime by improving its power quality, as well as to keep the system operating at an optimal and efficient power point. The algorithm adjusts the PEMFC operating point to the optimum power by tuning the duty cycle of the boost converter. The closed-loop system includes the Heliocentris hy-ExpertTM PEMFC, DC–DC boost converter, DSPACE DS1104, dedicated PC, and a programmable electronic load. The practical implementation of the proposed STA on a hardware setup is performed using a dSPACE real-time digital control platform. The data acquisition and the control system are conducted together with the dSPACE 1104 controller board. To demonstrate the performance of the proposed algorithm, experimental results are compared with 1-order sliding mode control (SMC) under different load resistance. The obtained results demonstrate the validity of the proposed control scheme by ensuring at least 72% of the maximum power produced by PEMFC. In addition, it is proven that the STA ensures all the fundamental properties of the 1-order SMC, as well as providing chattering reduction of 91%, which will ameliorate as a consequence the fuel cell lifetime.
What Does a Single-Item Measure of Job Stressfulness Assess?
Authors: Houdmont Jonathan , Jachens Liza , Randall Raymond , Hopson Sadie , Nuttall Sean , Pamia Stamatia
Published: April 2019

Single-item measures of global job stressfulness are increasingly used in occupational health research, yet their construct validity remains unexplored. This study used a qualitative approach to identify frames of reference that underlie self-ratings on such a measure. Data were collected from a convenience sample of 55 adults in full-time employment who completed a single-item measure inviting a rating of the extent to which their job is generally stressful. A cognitive interview schedule was used to explore the factors taken into account when providing a global rating, with thematic analysis applied to identify themes in the interview transcripts. The most common frames of reference were the presence of problematic psychosocial working conditions, particularly job demands. Health characteristics, predominantly poor psychological wellbeing, emerged as a further less dominant secondary theme. Almost half the sample cited four or more referents. In terms of the timeframe under consideration, most participants referred to a long timeframe such as their work in general, with some specifying their current job and, a few, recent weeks. These findings shed light on the frames of reference used to inform judgements on global job stressfulness elicited by a single-item measure and in doing so contribute to the evidence base to support the application of such measures in occupational health research and organisational psychosocial risk management activities.
Alternative Splicing in Angiogenesis
Authors: Bowler Elizabeth , Oltean Sebastian
Published: April 2019

Alternative splicing of pre-mRNA allows the generation of multiple splice isoforms from a given gene, which can have distinct functions. In fact, splice isoforms can have opposing functions and there are many instances whereby a splice isoform acts as an inhibitor of canonical isoform function, thereby adding an additional layer of regulation to important processes. Angiogenesis is an important process that is governed by alternative splicing mechanisms. This review focuses on the alternative spliced isoforms of key genes that are involved in the angiogenesis process; VEGF-A, VEGFR1, VEGFR2, NRP-1, FGFRs, Vasohibin-1, Vasohibin-2, HIF-1α, Angiopoietin-1 and Angiopoietin-2.
Green Synthesis of a Functionalized Zirconium-Based Metal–Organic Framework for Water and Ethanol Adsorption
Authors: Chen Zhijie , Wang Xingjie , Islamoglu Timur , Farha Omar K.
Published: April 2019

Aqueous synthesis of metal–organic frameworks (MOFs) at room temperature offers many advantages such as reduction in the generation of toxic byproducts and operation costs, as well as increased safety in the material’s production. Functional group-bearing MOFs have received growing attention compared to nonfunctionalized analogues due to enhanced adsorption properties of the former in many cases. Here, we report an aqueous solution-based synthesis of a robust zirconium MOF, UiO-66-NO2, at room temperature. We evaluated the phase purity, porosity, thermal stability, particle morphology and size of the resulting material. High uptake, as well as near complete recyclability of water and ethanol vapor isotherms at room temperature supports the potential of UiO-66-NO2 as a solid adsorbent in adsorption-based cooling applications or water harvesting systems.
Bridge Scour Identification and Field Application Based on Ambient Vibration Measurements of Superstructures
Authors: Xiong Wen , Cai C.S. , Kong Bo , Zhang Xuefeng , Tang Pingbo
Published: April 2019

A scour identification method was developed based on the ambient vibration measurements of superstructures. The Hangzhou Bay Bridge, a cable-stayed bridge with high scour potential, was selected to illustrate the application of this method. Firstly, two ambient vibration measurements were conducted in 2013 and 2016 by installing the acceleration sensors on the girders and pylon. By modal analysis, the natural frequencies of the superstructures were calculated with respect to different mode shapes. Then, by tracing the change of dynamic features between two measurements in 2013 and 2016, the discrepancies of the support boundary conditions, i.e., at the foundation of the Hangzhou Bay Bridge, were detected, which, in turn, qualitatively identified the existence of bridge foundation scour. Secondly, an FE model of the bridge considering soil-pile interaction was established to further quantify the scour depth in two steps. (1) The stiffness of the soil springs representing the support boundary of the bridge was initially identified by the model updating method. In this step, the principle for a successful identification is to make the simulation results best fit the measured natural frequencies of those modes insensitive to the scour. (2) Then, using the updated FE model, the scour depth was identified by updating the depth of supporting soils. In this step, the principle of model updating is to make the simulation results best fit the measured natural frequency changes of those modes sensitive to the scour. Finally, a comparison to the underwater terrain map of the Hangzhou Bay Bridge was carried out to verify the accuracy of the predicted scour depth. Based on the study in this paper, it shows that the proposed method for identifying bridge scour based on the ambient vibration measurements of superstructures is effective and convenient. It is feasible to quickly assess scour conditions for a large number of bridges without underwater devices and operations.
The Geographic Spread and Preferences of Tourists Revealed by User-Generated Information on Jeju Island, South Korea
Authors: Fisher David M. , Wood Spencer A. , Roh Young-Hee , Kim Choong-Ki
Published: April 2019

Recreation and tourism are important ways that people interact with and derive benefits from natural environments. Understanding how and where nature provides recreational opportunities and benefits is necessary for management decisions that impact the environment. This study develops and tests an approach for mapping tourism patterns, and assessing people’s preferences for cultural and natural landscapes, using user-generated geographic content. The volume of geotagged images and tweets shared publicly on Flickr and Twitter and proprietary mobile phone traffic provided by a telecommunications company, are used to map visitation rates to potential tourist destinations across Jeju Island, South Korea. We find that densities of social media posts and mobile phone traffic are all correlated with ticket sales and counts of gate entries at tourist sites. Using multivariate linear regression, we measure the degree to which attributes of the natural and built environment explain variation in visitation rates, and find that tourists to Jeju Island prefer to recreate near beaches, sea cliffs, golf courses and hiking trails. We conclude that high-resolution and spatially-explicit visitation data provided by user-generated content open the door for statistical models that can quantify recreation demand. Managers and practitioners could combine these flexible and relatively inexpensive user-generated data with more traditional survey data to inform sustainable tourism development plans and policy decisions. These methods are especially useful in the context of landscape or regional-scale ecosystem service assessments, where there is a need to map the multiple ecological, economic, and cultural benefits of the environment.
Investigations of the Friction Losses of Different Engine Concepts. Part 1: A Combined Approach for Applying Subassembly-Resolved Friction Loss Analysis on a Modern Passenger-Car Diesel Engine
Authors: Knauder Christoph , Allmaier Hannes , Sander David E. , Sams Theodor
Published: April 2019

This work presents the application of a combined approach to investigate the friction losses in a modern four-cylinder passenger-car diesel engine. The approach connects the results from engine friction measurements using the indication method and the results from journal-bearing simulations. The utilization of the method enables a subassembly-resolved friction loss analysis that yields the losses of the piston group, crankshaft journal bearings, and valve train (including the timing drive and crankshaft seals). The engine and engine subassembly friction losses are investigated over the full speed and load range, covering more than 120 engine operation points at different engine media supply temperatures ranging from 70 to 110 ∘ C. The subsequently decreasing lubricant viscosity due to higher engine media supply temperatures allow for the identification of friction reduction potentials as well as possible risks due to an onset of mixed lubrication. Furthermore, additional strip-tests have been conducted to determine the friction losses of the crankshaft radial lip seals, the timing drive, and the crankshaft journal bearings, thus enabling a verification of the calculated journal-bearing friction losses with measurement results. For the investigated diesel engine, a friction reduction potential of up to 21% could be determined when increasing the engine media supply temperature from 70 to 110 ∘ C, at engine speeds higher than n = 1500 rpm and part load operating conditions. At low engine speeds and high load operations, the friction loss reduction potential is considerably decreased and below 8%, indicating mixed lubrication regimes at the piston group and valve train.
Evaluation of a Catalyst Durability in Absence and Presence of Toluene Impurity: Case of the Material Co2Ni2Mg2Al2 Mixed Oxide Prepared by Hydrotalcite Route in Methane Dry Reforming to Produce Energy
Authors: Tanios Carole , Gennequin Cédric , Labaki Madona , Tidahy Haingomalala Lucette , Aboukaïs Antoine , Abi-Aad Edmond
Published: April 2019

Ni, Co, Mg, and Al mixed-oxide solids, synthesized via the hydrotalcite route, were investigated in previous works toward the dry reforming of methane for hydrogen production. The oxide Co2Ni2Mg2Al2 calcined at 800 °C, Co2Ni2Mg2Al2800, showed the highest catalytic activity in the studied series, which was ascribable to an interaction between Ni and Co, which is optimal for this Co/Ni ratio. In the present study, Co2Ni2Mg2Al2800 was compared to a commercial catalyst widely used in the industry, Ni(50%)/Al2O3, and showed better activity despite its lower number of active sites, as well as lower amounts of carbon on its surface, i.e. less deactivation. In addition to this, Co2Ni2Mg2Al2800 showed stability for 20 h under stream during the dry reforming of methane. This good durability is attributed to a periodic cycle of carbon deposition and removal as well as to the strong interaction between Ni and Co, preventing the deactivation of the catalyst. The evaluation of the catalytic performances in the presence of toluene, which is an impurity that exists in biogas, is also a part of this work. In the presence of toluene, the catalytic activity of Co2Ni2Mg2Al2800 decreases, and higher carbon formation on the catalyst surface is detected. Toluene adsorption on catalytic sites, side reactions performed by toluene, and the competition between toluene and methane in the reaction with carbon dioxide are the main reasons for such results.
Biomechanical Evaluation of Promising Different Bone Substitutes in a Clinically Relevant Test Set-Up
Authors: Brueckner Theresa , Heilig Philipp , Jordan Martin Cornelius , Paul Mila Marie , Blunk Torsten , Meffert Rainer Heribert , Gbureck Uwe , Hoelscher-Doht Stefanie
Published: April 2019

(1) Background: Bone substitutes are essential in orthopaedic surgery to fill up large bone defects. Thus, the aim of the study was to compare diverse bone fillers biomechanically to each other in a clinical-relevant test set-up and to detect differences in stability and handling for clinical use. (2) Methods: This study combined compressive strength tests and screw pullout-tests with dynamic tests of bone substitutes in a clinical-relevant biomechanical fracture model. Beyond well-established bone fillers (ChronOSTM Inject and Graftys® Quickset), two newly designed bone substitutes, a magnesium phosphate cement (MPC) and a drillable hydrogel reinforced calcium phosphate cement (CPC), were investigated. (3) Results: The drillable CPC revealed a comparable displacement of the fracture and maximum load to its commercial counterpart (Graftys® Quickset) in the clinically relevant biomechanical model, even though compressive strength and screw pullout force were higher using Graftys®. (4) Conclusions: The in-house-prepared cement allowed unproblematic drilling after replenishment without a negative influence on the stability. A new, promising bone substitute is the MPC, which showed the best overall results of all four cement types in the pure material tests (highest compressive strength and screw pullout force) as well as in the clinically relevant fracture model (lowest displacement and highest maximum load). The low viscosity enabled a very effective interdigitation to the spongiosa and a complete filling up of the defect, resulting in this demonstrated high stability. In conclusion, the two in-house-developed bone fillers revealed overall good results and are budding new developments for clinical use.
The Tribaloy T-800 Coatings Deposited by Laser Engineered Net Shaping (LENSTM)
Authors: Durejko Tomasz , Łazińska Magdalena , Dworecka-Wójcik Julita , Lipiński Stanisław , Varin Robert A. , Czujko Tomasz
Published: April 2019

A Tribaloy family of alloys (CoMoCrSi) are characterized by a substantial resistance to wear and corrosion within a wide range of temperatures. These properties are a direct result of their microstructure including the presence of Laves phase in varying proportions. Tribaloy T-800 exhibits the highest content of Laves phase of all other commercial Tribaloy alloys, which provides high hardness and wear resistance. On the other hand, a large content of the Laves phase brings about a high sensitivity to brittle fracture of this alloy. The main objective of this work was a development of the Tribaloy T-800 coatings on the Ni-based superalloy substrate (RENE 77), which employs a Laser Engineered Net Shaping (LENSTM) technique. Technological limitations in this process are susceptibility of T-800 to brittle fracture as well as significant thermal stresses due to rapid cooling, which is an inherent attribute of laser techniques. Therefore, in this work, a number of steps that optimized the LENSTM process and improved the metallurgical soundness of coatings are presented. Employing volume and local substrate pre-heating resulted in the formation of high quality coatings devoid of cracks and flaws.
Prediction of Deflection of Reinforced Concrete Beams Strengthened with Fiber Reinforced Polymer
Authors: Daugevičius Mykolas , Valivonis Juozas , Skuturna Tomas
Published: April 2019

The article analyses the calculation of the deflection of reinforced concrete beams strengthened with fiber reinforced polymer. This paper specifically focuses on estimating deflection when the yielding of reinforcement is reached. The article proposes a simple method for calculating deflection that was compared with the experimentally predicted deflection. The carried out comparison has showed that the proposed method is suitable not only for the strengthened beams but also for the reinforced concrete beams with a varying reinforcement ratio. The suggested calculation method is based on the effective moment of inertia, such as the one introduced in the ACI Committee 318 Building Code Requirement for Structural Concrete (ACI318). The development of deflection was divided into three stages, and equations for the effective moment of inertia were proposed considering separate stages. In addition, the put forward equations were modified attaching additional relative coefficients evaluating a change in the depth of the neutral axis.
Structures and Absolute Configurations of Diketopiperazine Alkaloids Chrysopiperazines A–C from the Gorgonian-Derived Penicillium chrysogenum Fungus
Authors: Xu Wei-Feng , Mao Ning , Xue Xiao-Jia , Qi Yue-Xuan , Wei Mei-Yan , Wang Chang-Yun , Shao Chang-Lun
Published: April 2019

Three new diketopiperazine alkaloids, including two oxepine-containing diketopiperazines, chrysopiperazines A and B (1 and 2), and one quinazoline-containing diketopiperazine, chrysopiperazine C (5), together with three known analogues (3, 4, and 6), were isolated from the gorgonian-derived Penicillium chrysogenum fungus. The relative and absolute configurations of C-3 and C-15 in 1 and 2, C-3 and C-14 in 5 were established by NOE modified Marfey’s analysis and electronic circular dichroism (ECD) calculations. Particularly, the absolute configurations of C-19 in 1 and 3, which was very challenging to be identified due to the flexible conformation in a short aliphatic chain, were successfully determined by the vibrational circular dichroism (VCD) method, supplying with a reliable and optional method to define the absolute configurations. Additionally, this is the first report on oxepine-containing diketopiperazines from the genus Penicillium.
A Fault-Tolerant Data Fusion Method of MEMS Redundant Gyro System Based on Weighted Distributed Kalman Filtering
Authors: Du Binhan , Shi Zhiyong , Song Jinlong , Wang Huaiguang , Han Lanyi
Published: April 2019

The application of the Micro Electro-mechanical System (MEMS) inertial measurement unit has become a new research hotspot in the field of inertial navigation. In order to solve the problems of the poor accuracy and stability of MEMS sensors, the redundant design is an effective method under the restriction of current technology. The redundant data processing is the most important part in the MEMS redundant inertial navigation system, which includes the processing of abnormal data and the fusion estimation of redundant data. A developed quality index of the MEMS gyro measurement data is designed by the parity vector and the covariance matrix of the distributed Kalman filtering. The weight coefficients of gyros are calculated according to this index. The fault-tolerant fusion estimation of the redundant data is realized through the framework of the distributed Kalman filtering. Simulation experiments are conducted to test the performance of the new method with different types of anomalies.
Milk Therapy: Unexpected Uses for Human Breast Milk
Authors: Witkowska-Zimny Malgorzata , Kamińska-El-Hassan Ewa , Wróbel Edyta
Published: April 2019

Background: Human breast milk provides a child with complete nutrition but is also a popular therapeutic remedy that has been used in traditional, natural pharmacopeia, and ethnomedicine for many years. The aim of this current review is to summarize studies of non-nutritional uses of mothers’ milk. Methods: Two databases (PubMed and Google Scholar) were searched with a combination of twelve search terms. We selected articles that were published between 1 January 2010, and 1 January 2019. The language of publication was limited to English. Results: Fifteen studies were included in the systematic review. Ten of these were randomized controlled trials, one was a quasi-experimental study, two were in vitro studies, and four employed an animal research model. Conclusions: Many human milk components have shown promise in preclinical studies and are undergoing active clinical evaluation. The protective and treatment role of fresh breast milk is particularly important in areas where mothers and infants do not have ready access to medicine.
Influence of Resveratrol on the Immune Response
Authors: Malaguarnera Lucia
Published: April 2019

Resveratrol is the most well-known polyphenolic stilbenoid, present in grapes, mulberries, peanuts, rhubarb, and in several other plants. Resveratrol can play a beneficial role in the prevention and in the progression of chronic diseases related to inflammation such as diabetes, obesity, cardiovascular diseases, neurodegeneration, and cancers among other conditions. Moreover, resveratrol regulates immunity by interfering with immune cell regulation, proinflammatory cytokines’ synthesis, and gene expression. At the molecular level, it targets sirtuin, adenosine monophosphate kinase, nuclear factor-κB, inflammatory cytokines, anti-oxidant enzymes along with cellular processes such as gluconeogenesis, lipid metabolism, mitochondrial biogenesis, angiogenesis, and apoptosis. Resveratrol can suppress the toll-like receptor (TLR) and pro-inflammatory genes’ expression. The antioxidant activity of resveratrol and the ability to inhibit enzymes involved in the production of eicosanoids contribute to its anti-inflammation properties. The effects of this biologically active compound on the immune system are associated with widespread health benefits for different autoimmune and chronic inflammatory diseases. This review offers a systematic understanding of how resveratrol targets multiple inflammatory components and exerts immune-regulatory effects on immune cells.
A Review of Dietary Therapy for IBD and a Vision for the Future
Authors: Green Nicole , Miller Talya , Suskind David , Lee Dale
Published: April 2019

Inflammatory bowel disease (IBD) is a chronic inflammatory condition affecting the gastrointestinal tract. The rising incidence of IBD has been associated with urbanization and shifts toward a Westernized diet. The intestinal microbiome has been a focus of disease pathogenesis and also therapeutic intervention. Dietary therapy for IBD has been well-studied with exclusive enteral nutrition, a formula-based diet with the exclusion of foods. In addition, interest in food-based exclusion diets has been increasing, with patients and families leading the charge. Challenges with dietary therapy for IBD include the lack of understanding of a detailed mechanistic pathway to explain the impact of diet on IBD pathogenesis and the difficult nature of designing and implementing dietary clinical trials. Epidemiological studies have demonstrated associations and intervention studies have demonstrated efficacy, but specific dietary targets remain as hypotheses at present. Current IBD therapy focuses on suppression of the immune system, yet the incomplete efficacy of present drugs suggests that other therapies must be developed and employed. Dietary interventions, with known ability to modulate the intestinal microbiome, are a unique opportunity to improve outcomes in IBD. Dietary intervention trials are challenging, and capturing both broad dietary patterns as well as exposure to individual food compounds is important. With increasing patient interest and preliminary research in dietary therapy indicating efficacy, it is imperative to further advance the science of utilizing diet in IBD, as well as to support patients by proactively addressing diet within their care plan.
Effect of Maternal Obesity and Preconceptional Weight Loss on Male and Female Offspring Metabolism and Olfactory Performance in Mice
Authors: Panchenko Polina E. , Lacroix Marie-Christine , Jouin Mélanie , Voisin Sarah , Badonnel Karine , Lemaire Marion , Meunier Nicolas , Safi-Stibler Sofiane , Persuy Marie-Annick , Jouneau Luc , Durieux Didier , Lecoutre Simon , Jammes Hélène , Rousseau-Ralliard Delphine , Breton Christophe , Junien Claudine , Baly Christine , Gabory Anne
Published: April 2019

According to the “developmental origins of health and disease” (DOHaD) concept, maternal obesity predisposes the offspring to non-communicable diseases in adulthood. While a preconceptional weight loss (WL) is recommended for obese women, its benefits on the offspring have been poorly addressed. We evaluated whether preconceptional WL was able to reverse the adverse effects of maternal obesity in a mouse model, exhibiting a modification of foetal growth and of the expression of genes encoding epigenetic modifiers in liver and placenta. We tracked metabolic and olfactory behavioural trajectories of offspring born to control, obese or WL mothers. After weaning, the offspring were either put on a control diet (CD) or a high-fat (HFD). After only few weeks of HFD, the offspring developed obesity, metabolic alterations and olfactory impairments, independently of maternal context. However, male offspring born to obese mother gained even more weight under HFD than their counterparts born to lean mothers. Preconceptional WL normalized the offspring metabolic phenotypes but had unexpected effects on olfactory performance: a reduction in olfactory sensitivity, along with a lack of fasting-induced, olfactory-based motivation. Our results confirm the benefits of maternal preconceptional WL for male offspring metabolic health but highlight some possible adverse outcomes on olfactory-based behaviours.
The Effects of High Peripubertal Caffeine Exposure on the Adrenal Gland in Immature Male and Female Rats
Authors: Ryu Ki-Young , Roh Jaesook
Published: April 2019

The consumption of high levels of dietary caffeine has increased in children and adolescents. Human and animal studies have shown that chronic intake of high doses of caffeine affects serum glucocorticoid levels. Given that glucocorticoids play a role in peripubertal organ growth and development, chronic high doses of caffeine during puberty might impair maturation of the adrenal glands. To evaluate any effects of caffeine exposure on growing adrenal glands, 22-day-old male (n = 30) and female Sprague Dawley rats (n = 30) were divided into three groups (n = 10/group); group 1 received tap water (control) and groups 2 and 3 received water containing 120 and 180 mg/kg/day caffeine, respectively, via gavage for 4 weeks. At the end of the experiment, adrenal glands were weighed and processed for histological analysis. Relative adrenal weights increased in both groups of caffeine-fed males and females, whereas absolute weights were decreased in the females. In the female caffeine-fed groups the adrenal cortical areas resembled irregularly arranged cords and the medullary area was significantly increased, whereas no such effects were seen in the male rats. Our results indicate that the harmful effects of caffeine on the adrenal glands of immature rats differ between females and males. Although female rats seemed to be more susceptible to damage based on the changes in the microarchitecture of the adrenal glands, caffeine affected corticosterone production in both female and male rats. In addition, increased basal adrenocorticotropic hormone levels in caffeine-fed groups may reflect decreased cortical function. Therefore, caffeine may induce an endocrine imbalance that disturbs the establishment of the hypothalamo–pituitary adrenal axis during puberty, thereby leading to abnormal stress responses.
Using the Avocado to Test the Satiety Effects of a Fat-Fiber Combination in Place of Carbohydrate Energy in a Breakfast Meal in Overweight and Obese Men and Women: A Randomized Clinical Trial
Authors: Zhu Lanjun , Huang Yancui , Edirisinghe Indika , Park Eunyoung , Burton-Freeman Britt
Published: April 2019

This study aimed to investigate the satiety effects of isocalorically replacing carbohydrate energy in a meal with avocado-derived fats and fibers. In a randomized 3-arm, 6-h, crossover clinical trial, thirty-one overweight/obese adults consumed a low-fat control meal (CON, 76% carbohydrate, 14% fat as energy, 5 g fiber, ~640 kcal) or high-fat meals similar in total fat and energy, but increasing avocado-derived fat and fiber content from half (HA, 68 g; 51% carbohydrate, 40% fat as energy, 8.6 g fiber) or whole avocado (WA, 136 g; 50% carbohydrate, 43% fat as energy, 13.1 g fiber) on three separate occasions. Visual analog scales (VAS) assessed subjective satiety over 6 h. Hormones associated with satiety/appetite were measured in blood collected immediately after VAS. Stepwise multiple regression analysis was used to assess the relationship of VAS with hormones in WA and CON. Hunger suppression was enhanced after the WA compared to CON meal (p < 0.01). Subjects indicated feeling more satisfied after both HA and WA than CON (p < 0.05). Fullness was greater after CON and WA vs. HA (p < 0.005). PYY and GLP-1 were significantly elevated after WA vs. CON (p < 0.05), while insulin was significantly higher after CON vs. WA (p < 0.0001). Ghrelin was suppressed more by CON than WA (p < 0.05). Regression analysis indicated PYY was associated with subjective satiety after WA, whereas increased insulin predicted changes in subjective satiety after CON. Replacing carbohydrates in a high-carbohydrate meal with avocado-derived fat-fiber combination increased feelings of satiety mediated primarily by PYY vs. insulin. These findings may have important implications for addressing appetite management and metabolic concerns.
The Effect of Ketoanalogues on Chronic Kidney Disease Deterioration: A Meta-Analysis
Authors: Li Albert , Lee Hsiang-Yen , Lin Yen-Chung
Published: April 2019

The effects of ketoanalogues (KA) on chronic kidney disease (CKD) deterioration have not yet been fully confirmed. To strengthen the evidence of the role of KA in CKD, PubMed and Embase were searched for studies published through February 2019. Effect sizes from ten randomized control trials (RCTs) and two non-RCTs comprising a total of 951 patients were pooled and analyzed. A restricted protein diet supplemented with ketoanalogues (RPKA) was found to significantly delay the progression of CKD (p = 0.008), particularly in patients with an estimated glomerular filtration rate (eGFR) > 18 mL/min/1.73 m2 (p < 0.0001). No significant change in eGFR was found when comparing a very-low-protein diet and a low-protein diet (p = 0.10). In addition, compared with the placebo, RPKA did not cause malnutrition (albumin: p = 0.56; cholesterol: p = 0.50). Moreover, RPKA significantly decreased phosphorous levels (p = 0.001), increased calcium levels (p = 0.04), and decreased parathyroid hormone (PTH) levels (p = 0.05) in patients with eGFR < 18 mL/min/1.73 m2. In conclusion, RPKA could slow down the progression of CKD in patients with eGFR > 18 mL/min/1.73 m2 without causing malnutrition and reverse CKD-MBD in patients with eGFR < 18 mL/min/1.73 m2.
Questioning the Safety of Calcidiol in Hemodialysis Patients
Authors: Villa-Bellosta Ricardo , Mahillo-Fernández Ignacio , Ortíz Alberto , González-Parra Emilio
Published: April 2019

Background. Epidemiological studies have suggested a survival benefit for hemodialysis patients on paricalcitol or calcitriol, but nutritional vitamin D supplementation of patients already on vitamin D receptor (VDR) activators is controversial. Methods. This observational retrospective cohort study was conducted with prospectively collected data from all consecutive patients with chronic kidney disease (CKD) who underwent hemodialysis under routine clinical practice conditions for two years. Results. Of the 129 patients, 89 were treated with calcidiol, paricalcitol, and/or calcitriol. The patients with any vitamin D formulation had higher serum concentrations of 25-hydroxy vitamin D and fibroblast growth factor-23 and tended to have higher mortality rates (42% vs. 25%, p = 0.07). On subgroup analysis, any calcidiol treatment or calcidiol combined with paricalcitol associated with significantly higher mortality rates than no treatment (47% and 62.5%, p = 0.043 and 0.008, respectively). The association between calcidiol/paricalcitol treatment and elevated mortality remained significant after adjusting for age, sex, diabetes, C-reactive protein, and hemodialysis vintage. Any calcidiol and calcidiol/paricalcitol treatment exhibited a dose-response relationship with mortality (p for trend: 0.002 and 0.005, respectively). Conclusions. These data draw attention to the hitherto unexplored safety of calcidiol supplementation in patients on hemodialysis, especially in those already on vitamin D. Until clinical trials demonstrate the safety and efficacy of this approach, caution should be exercised when prescribing these patients ≥0.5 calcidiol mg/month.
Re-Epithelialization Appraisal of Skin Wound in a Porcine Model Using a Salmon-Gelatin Based Biomaterial as Wound Dressing
Authors: Acevedo Cristian A. , Sánchez Elizabeth , Orellana Nicole , Morales Patricio , Olguín Yusser , Brown Donald I. , Enrione Javier
Published: April 2019

The design of new functional materials for skin tissue engineering is an area of constant research. In this work, a novel wound-dressing biomaterial with a porous structure, previously formulated using salmon-gelatin as main component (called salmon-gelatin biomaterial (SGB)), was tested in vivo using pigs as skin wound models. Four weeks after cutaneous excision and implantation in the animals, the healing process did not show apparent symptoms of inflammation or infection. Interestingly, the temporal evolution of wound size from 100% to around 10% would indicate a faster recovery when SGB was compared against a commercial control. Histological analysis established that wounds treated with SGB presented similar healing and epithelialization profiles with respect to the commercial control. Moreover, vascularized granulation tissue and epithelialization stages were clearly identified, indicating a proliferation phase. These results showed that SGB formulation allows cell viability to be maintained. The latter foresees the development of therapeutic alternatives for skin repair based on SGB fabricated using low cost production protocols.
Geometric Processing and Accuracy Verification of Zhuhai-1 Hyperspectral Satellites
Authors: Jiang Yonghua , Wang Jingyin , Zhang Li , Zhang Guo , Li Xin , Wu Jiaqi
Published: April 2019

The second batch of Zhuhai-1 microsatellites was successfully launched on 26 April 2018. The batch included four Orbita hyperspectral satellites (referred to as OHS-A, OHS-B, OHS-C, and OHS-D) and one video satellite (OVS-2A), which have excellent hyperspectral data acquisition abilities. For the first time in China, a number of hyperspectral satellite networks have been realized. To ensure the application of hyperspectral remote sensing data, a series of on-orbit geometry processing and accuracy verification studies has been carried out on the “Zhuhai-1” hyperspectral camera since the satellite was launched. This paper presents the geometric processing methods involved in the production of Zhuhai-1 hyperspectral satellite basic products, including geometric calibration and basic product production algorithms. The OHS images were used to perform on-orbit geometric calibration, and the calibration accuracy was better than 0.5 pixels. The registration accuracy of the image spectrum of the basic product after calibration, the single orientation accuracy, and the accuracy of the regional network adjustment were evaluated. The spectral registration accuracy of the OHS basic products is 0.3–0.5 pixels, which is equivalent to the spectral band calibration accuracy. The single orientation accuracy is better than 1.5 pixels and the regional network adjustment accuracy is better than 1.2 pixels. The generated area orthoimages meet the seamless edge requirements, which verifies that the OHS basic product image has good regional mapping capabilities and can meet the application requirements.
A New Method of Mixed Gas Identification Based on a Convolutional Neural Network for Time Series Classification
Authors: Han Lu , Yu Chongchong , Xiao Kaitai , Zhao Xia
Published: April 2019

This paper proposes a new method of mixed gas identification based on a convolutional neural network for time series classification. In view of the superiority of convolutional neural networks in the field of computer vision, we applied the concept to the classification of five mixed gas time series data collected by an array of eight MOX gas sensors. Existing convolutional neural networks are mostly used for processing visual data, and are rarely used in gas data classification and have great limitations. Therefore, the idea of mapping time series data into an analogous-image matrix data is proposed. Then, five kinds of convolutional neural networks—VGG-16, VGG-19, ResNet18, ResNet34 and ResNet50—were used to classify and compare five kinds of mixed gases. By adjusting the parameters of the convolutional neural networks, the final gas recognition rate is 96.67%. The experimental results show that the method can classify the gas data quickly and effectively, and effectively combine the gas time series data with classical convolutional neural networks, which provides a new idea for the identification of mixed gases.
A Fourier-Based Image Formation Algorithm for Geo-Stationary GNSS-Based Bistatic Forward-Looking Synthetic Aperture Radar
Authors: Zeng Zhangfan , Shi Zhiming , Xing Sainan , Pan Yongcai
Published: April 2019

A Geo-Stationary GNSS-based Bistatic Forward-Looking Synthetic Aperture Radar (GeoSta-GNSS-BFLSAR) system is a particular kind of passive bistatic SAR system. In this system, a geo-stationary GNSS is used as the transmitter, while the receiver is deployed on a moving aircraft, which travels towards a target in a straight line. It is expected that such a radar system has potential for self-landing, self-navigation and battlefield information acquisition applications, etc. Up to now, little information from a research perspective can be found about GeoSta-GNSS-BFLSAR systems. To address this information gap, this paper proposes a preliminary image formation algorithm for GeoSta-GNSS-BFLSAR. The full details of the mathematical derivation are given. It is highlighted that, to overcome the long dwell time and spatial variance of GeoSta-GNSS-BFLSAR, a modified migration correction factor must be designed. In addition, the system performances and technical limitations of GeoSta-GNSS-BFLSAR such as focusing depth and spatial resolution are analytically discussed. In the end, a set of simulations including the image formation algorithm, focusing depth and spatial resolution were conducted for verification. It is demonstrated that the focusing performances of the proposed algorithm have a high level of similarity with the theoretical counterparts. This article thus proves the feasibility of GeoSta-GNSS-BFLSAR systems from a simulation level and establishes a foundation for the real applications of such a radar scheme in the future.
The Effect of Vitamin D Supplementation on Skeletal Muscle in the mdx Mouse Model of Duchenne Muscular Dystrophy
Authors: Debruin Danielle A. , Andreacchio Nicola , Hanson Erik D. , Timpani Cara A. , Rybalka Emma , Hayes Alan
Published: April 2019

Vitamin D (VitD) has shown to be beneficial in reversing muscle weakness and atrophy associated with VitD deficiency. Duchenne muscular dystrophy is characterized by worsening muscle weakness and muscle atrophy, with VitD deficiency commonly observed. This study aimed to investigate the effect of VitD supplementation on dystrophic skeletal muscle. Eight-week old female control (C57BL/10; n = 29) and dystrophic (C57BL/mdx; n = 23) mice were randomly supplemented with one of three VitD enriched diets (1000, 8000 & 20,000 IU/kg chow). Following a four-week feeding period, the extensor digitorum longus (EDL) and soleus muscles contractile and fatigue properties were tested ex vivo, followed by histological analysis. As expected, mdx muscles displayed higher mass yet lower specific forces and a rightward shift in their force frequency relationship consistent with dystrophic pathology. There was a trend for mdx muscle mass to be larger following the 20,000 IU/kg diet, but this did not result in improved force production. Fiber area in the EDL was larger in mdx compared to controls, and there were higher amounts of damage in both muscles, with VitD supplementation having no effect. Four weeks of VitD supplementation did not appear to have any impact upon dystrophic skeletal muscle pathology at this age.