bluuebunny/crossref_metadata_2025 huggingface dataset:
The linear feedback precipitation model (LFPM 1.0) – a simple and efficient model for orographic precipitation in the context of landform evolution modeling
Authors: Hergarten Stefan , Robl Jörg
Published: March 2022

Abstract. The influence of climate on landform evolution has attracted great interest over the past decades. While many studies aim at determining erosion rates or parameters of erosion models, feedbacks between tectonics, climate, and landform evolution have been discussed but addressed quantitatively only in a few modeling studies. One of the problems in this field is that coupling a large-scale landform evolution model with a regional climate model would dramatically increase the theoretical and numerical complexity. Only a few simple models have been made available so far that allow efficient numerical coupling between topography-controlled precipitation and erosion. This paper fills this gap by introducing a quite simple approach involving two vertically integrated moisture components (vapor and cloud water). The interaction between the two components is linear and depends on altitude. This model structure is in principle the simplest approach that is able to predict both orographic precipitation at small scales and a large-scale decrease in precipitation over continental areas without introducing additional assumptions. Even in combination with transversal dispersion and elevation-dependent evapotranspiration, the model is of linear time complexity and increases the computing effort of efficient large-scale landform evolution models only moderately. Simple numerical experiments applying such a coupled landform evolution model show the strong impact of spatial precipitation gradients on mountain range geometry including steepness and peak elevation, position of the principal drainage divide, and drainage network properties.
Compound flood modeling framework for surface–subsurface water interactions
Authors: Peña Francisco , Nardi Fernando , Melesse Assefa , Obeysekera Jayantha , Castelli Fabio , Price René M. , Crowl Todd , Gonzalez-Ramirez Noemi
Published: March 2022

Abstract. Compound floods are an active area of research in which the complex interaction between pluvial, fluvial, coastal and groundwater flooding are analyzed. A number of studies have simulated the compound flooding impacts of precipitation, river discharge and storm surge variables with different numerical models and linking techniques. However, groundwater flooding is often neglected in flood risk assessments due to its sporadic frequency (as most regions have water tables sufficiently low that do not
exacerbate flooding conditions), isolated impacts and considerably lower
severity with respect to other types of flooding. This paper presents a
physics-based, loosely coupled modeling framework using FLO-2D and
MODFLOW-2005 that is capable of simulating surface–subsurface water
interactions. FLO-2D, responsible for the surface hydrology and infiltration processes, transfers the infiltration volume as recharge to MODFLOW-2005 until the soil absorption capacity is exceeded, while MODFLOW-2005 returns exchange flow to the surface when the groundwater heads are higher than the surface depth. Three events characterized by short-duration intense precipitation, average tide levels and unusually high water table levels are used to assess the relevance of groundwater flooding in the Arch Creek Basin, a locality in North Miami particularly prone to flooding conditions. Due to limitations in water level observations, the model was calibrated based on properties that have experienced repetitive flooding losses and validated using image-based volunteer geographic information (VGI). Results suggest that groundwater-induced flooding is localized, and high groundwater heads influence pluvial flooding as the shallow water table undermines the soil infiltration capacity. Understanding groundwater flood risk is of particular interest to low-elevation coastal karst environments as the
sudden emergence of the water table at ground surface can result in social
disruption, adverse effects to essential services and damage to infrastructure. Further research should assess the exacerbated impacts of
high tides and sea level rise on water tables under current and future
climate projections.
Invited perspectives: Challenges and future directions in improving bridge flood resilience
Authors: Tubaldi Enrico , White Christopher J. , Patelli Edoardo , Mitoulis Stergios Aristoteles , de Almeida Gustavo , Brown Jim , Cranston Michael , Hardman Martin , Koursari Eftychia , Lamb Rob , McDonald Hazel , Mathews Richard , Newell Richard , Pizarro Alonso , Roca Marta , Zonta Daniele
Published: March 2022

Abstract. Bridges are critical-infrastructure components of road and rail
transport networks. A large number of these critical assets cross or are
adjacent to waterways and floodplains and are therefore exposed to flood
actions such as scour, hydrodynamic loading, and inundation, all of which are
exacerbated by debris accumulations. These stressors are widely recognized
as responsible for the vast majority of bridge failures around the world,
and they are expected to be exacerbated due to climate change. While efforts
have been made to increase the robustness of bridges to the flood hazard,
many scientific and technical gaps remain. These gaps were explored during
an expert workshop that took place in April 2021 with the participation of
academics, consultants, and decision makers operating mainly in the United
Kingdom and specializing in the fields of bridge risk assessment and
management and flood resilience. The objective of the workshop was to
identify and prioritize the most urgent and significant impediments to
bridge flood resilience. In particular, the following issues, established at
different levels and scales of bridge flood resilience, were identified and
analysed in depth: (i) characterization of the effects of floods on
different bridge typologies, (ii) uncertainties in formulae for scour depth
assessment, (iii) evaluation of consequences of damage, (iv) recovery
process after flood damage, (v) decision-making under uncertainty for
flood-critical bridges, and (vi) use of event forecasting and monitoring
data for increasing the reliability of bridge flood risk estimations. These
issues are discussed in this paper to inform other researchers and
stakeholders worldwide, guide the directions of future research in the
field, and influence policies for risk mitigation and rapid response to
flood warnings, ultimately increasing bridge resilience.
Antarctic surface climate and surface mass balance in the Community Earth System Model version 2 (1850–2100)
Authors: Dunmire Devon , Lenaerts Jan T. M. , Datta Rajashree Tri , Gorte Tessa
Published: March 2022

Abstract. Antarctic Ice Sheet (AIS) mass loss can be mitigated by an increase in surface mass balance (SMB) which is impacted by the ice sheet's surface climate. Because of Antarctica’s remoteness, in-situ observations of its surface climate are spatially and temporally sparse, limiting our understanding of how the surface climate, and therefore SMB, are changing. To that end, Earth System Models (ESMs) fill an important gap, allowing us to explore components of the AIS climate system, both historically and under future climate change scenarios. Here, we present and analyze output of the most recent version of the National Center for Atmospheric Research’s ESM: the Community Earth System Model version 2 (CESM2). We compare AIS surface climate and SMB as simulated by CESM2 with regional climate models and observations. We find that CESM2 substantially better represents AIS near-surface temperature, wind speed, and surface melt compared with its predecessor, CESM1, which is likely a result of the inclusion of new cloud microphysical parameterizations and changes made to the snow model. However, CESM2 SMB is shown to be biased high, particularly because of excessive precipitation. ESMs such as CESM2 are used as forcing for ice sheet models, which provide estimates and projections of ice sheet contribution to sea level rise. Thus, it is important to fully understand the limitations and biases of this climate model forcing. This study provides a comprehensive analysis of the strengths and weaknesses of CESM2 representation of AIS surface climate, which will be especially useful in preparation for CESM3, which plans to incorporate a coupled Antarctic Ice Sheet that interacts with the ocean and atmosphere.
Improving Quality Assurance at South Carolina Vocational Rehabilitation Department: Developing a New Electronic Tool
Authors: Anderson Carol , Johnson Felicia , Neel Jerry , Hoover Phyllis
Published: March 2022

When the Workforce Innovation and Opportunity Act (WIOA) was signed into law in 2014, the South Carolina Vocational Rehabilitation Department (SCVRD) considered how to best evaluate and measure compliance in light of the new performance measures. For many years, SCVRD used a paper form to measure quality assurance within cases across the state. This project developed a new, electronic program based on WIOA definitions and regulatory interpretation provided by the Rehabilitation Services Administration (RSA), as well as rehabilitation counselor competencies, and evaluated its effectiveness in the field. Participants reported satisfaction with the instrument’s ease of use and ability to reflect accurately the agency’s efforts concerning the new WIOA standards. This information will be used to demonstrate the quality of the VR program to stakeholders, train staff on the paradigm shift of the new WIOA service delivery model, and ensure the agency continues to serve a national leader in its commitment to meeting the vocational needs of individuals with disabilities.
Building on Students’ Perspectives on Moving to Online Learning during the COVID-19 Pandemic
Authors: Kelly Katharine
Published: March 2022

This paper provides insights from students and the author’s experiences of the move to online course delivery in the current pandemic. Key issues students identified as impacting success include: student stress/distress related to the pandemic, challenges with Wi-Fi and connectivity, students’ and instructors’ technical skills, and issues related to course design and delivery method (synchronous or asynchronous). Students’ insights, the instructor’s experiences, and the academic literature on online education are used to provide suggestions for addressing these challenges. This analysis began as an exercise to inform my course planning but led to a recognition that (a) a successful transition requires action by students, instructors, and institutions and (b) that these actions are constrained making successful transitions both demanding and difficult.
Faculty Perspectives on UDL: Exploring Bridges and Barriers for Broader Adoption in Higher Education
Authors: Hills Melissa , Overend Alissa , Hildebrandt Shawn
Published: March 2022

Universal Design for Learning (UDL) strategies aim to reduce learning barriers in the classroom for all students and remove the need for students with disabilities to advocate on their own behalf. Leadership in Scholarship of Teaching and Learning has a role to play in advancing inclusive learning cultures in higher education. At the frontline of higher education delivery, faculty are best positioned to implement UDL practices. Initiatives to encourage broader implementation of UDL require an understanding of the barriers and opportunities in higher education. Published studies that investigate faculty understanding and implementation of UDL have been almost exclusively conducted in US institutions. Our study enriches the existing literature through a mixed methods approach with interviews and a faculty survey in a Canadian context. Themes revealed in our interviews were reinforced by survey findings. Many of the issues raised by faculty, including time and resource constraints, a lack of institutional support, and a lack of understanding are consistent with previous research done in the US, highlighting the systemic challenges for UDL implementation in higher education. To conclude, we explore the limits of a strictly bottom-up approach and contend, in line with recent studies, that top-down initiatives are also vital to encouraging broader implementation of UDL practices.
The prolonged effect of GLUTAM 1M biologically active preparation on dairy productivity and milk quality of cows
Authors: Trokhymenko Vita , Kovalchuk Тetyana , Bidenko Volodymyr , Zakharin Viacheslav , Pylypchuk Оksana
Published: March 2022

We have studied the effect of biologically active preparation of metabolic-neurotropic action “Glutam 1M” on milk productivity of cows and quality indicators of raw milk. This preparation was used for dry cows in the last trimester of pregnancy. Studies were performed in the private agricultural enterprise “Savertsi” of Popilnyansky district of Zhytomyr region on cows of Holstein breed. The biologically active preparation “Glutam 1M” has been administered to the cows of the experimental groups under the skin behind the shoulder blade in an amount of 20 ml, starting from 270 and 265 days of gestation, once a day for three consecutive days. Cows of control groups were injected with saline in the same dose. Using the biologically active preparation “Glutam 1M”, a milk yield decreased slightly by 2% (91.9 kg). The milk yield increased by 2.9% (141.5 kg) in the control group. 305-days milk yield in the control group of cows was almost the same as in the previous lactation period. During the experiment, the experimental group of cows – has decreased by 2.9% (136.5 kg). A similar situation has been observed during the biologically active preparation “Glutam 1M” on the 270 – 272th days of pregnancy. Milk yield in the experimental group of animals for the previous lactation and after the use of preparation remained almost at the same level in the control group – decreased by 4.7% (207.1 kg). 305-days milk yield in the control group of cows for the previous and post-lactation experiment period was almost the same. In the experimental group of animals, there was an increase in this indicator by 2.7% (128.7 kg). The use of the “Glutam 1M” preparation did not affect milk quality, namely the mass fraction of fat and protein; fluctuations of the above indicators stayed within the error.
Slingbag Design For Street Feeding Activities Feed Not Bomb Bandung
Authors: Delia Adisti , Waskito Mohamad
Published: March 2022

This research is the process of designing sling bag street feeding activities intended for the Bandung feed not bomb community at the age of 20-25 years. This research is based on the needs and opportunities due to cat overpopulation and the issue of welfare of abandoned animals that occur in Indonesia resulting in the emergence of the movement to care for abandoned animals. Based on data taken in the community feed not bomb Bandung street feeding activities are one of the alternatives that can be done to help the welfare of cats, but when the activity takes place street feeders to have difficulty bringing the needs of street feeding activities. The purpose of this research is to produce a sling bag product design that can organize luggage, make it easier for users, and must have good durability. The resulting design has a novelty value offered, namely sling bag devoted to the use of street feeding activities because there is no special bag to support these activities. The design process is carried out through the design thinking process approach and at the end of the process is produced a prototype design is tested on street feeding activities.
Double Channel CNN Based Tomato Plant Leaf Disease Detection
Authors: Kumar Naveen
Published: March 2022

Early blight, late blight, bacterial spot, leaf mold, spider mites, yellow leaf curl virus and Septoria leaf spot are the most common diseases of tomato plant which cause major loss to agriculture sector. Diagnosis and prognosis at early stage are prime challenges to save life of tomato crop. This research presents a state-of-the-art Double-Channel Convolution Neural Network (D-CNN) model for diagnoses of 8 different Classes of Tomato Plant Leaves. The proposed model integrates two separate Convolutional Neural Network (CNN) channels with similar number of Conv Layers and Parameters. One Channel processes the pre-processed Red-Green-Blue (RGB) data, whereas the second channel processes the region segmented data obtained by applying a Multi-Otsu Thresholding algorithm. We verified the proposed model on the Plant Village dataset which consists of more than 16,000 images of tomato plant leaves. The proposed model attains an overall accuracy of 94% after 200 iterations, comparatively 3.2% faster than Support Vector Machine (SVM), 2.2% faster than Probabilistic Neural Network (PNN), and 8% faster than Residual Neural Network (ResNet-50).
Modification of Vogel's Approximation Method for Optimality of Transportation Problem by Statistical Technique
Authors: Sahito Sabeen
Published: March 2022

This paper addresses the Optimality of Transportation Problems (TP). The modification in Vogel’s Approximation Method for optimality of transportation problem by statistical technique (MVOTPST) is proposed, which provides the better feasible solution in comparison to the existing methods such as North West Corner Method (NWCM), Least Cost Method (LCM) and Vogel’s Approximation Method (VAM). Various examples have been examined from the literature to validate the authenticity and optimality of the proposed MVOTPST method. Furthermore, the Initial Basic Feasible Solution (IBFS) of the modified technique has been found either absolutely optimal, close to optimal, same as VAM, or better than the existing methods.
Stabilizing and Controlling the Altitude and Attitude of Remotely Operated Underwater Fishing Drone
Authors: Farooq Fahad
Published: March 2022

Fishing is one of the most intense and time-consuming occupations. Sometimes it's hard to find a healthy fish population and fishermen to travel far offshore for this purpose and it's sometimes dangerous in bad weather conditions. The study focuses on controlling and stabilizing the altitude and attitude of the fishing drone. This manuscript designs dual control based on model adaptive control (MAC) with Proportional integral derivative (PID). It also uses an integral as the feedback. MAC deals with the disturbances and PID tunes the systems adaptive gain. Furthermore, the Lyapunov stability criterion helps in maintaining the stability of the system. The feedback removes the steady-state error and improves the convergence rate. The simulation results verify the accuracy and effectiveness of the designed scheme. The designs scheme shows high convergence, low steady-state error, and better robustness.
Synthesis of Bio-Adsorbent for Removal of Fluoride from Groundwater – A column study
Authors: Memon Mariam Mir
Published: March 2022

High fluoride levels in groundwater used for drinking have caused health concerns for millions of people across the world. Pakistan is one of the countries that have been contaminated by these toxins. However, a little amount of fluoride is required for tooth and bone strength. In any event, the presence of too much of it in drinking water can cause diseases in both people and animals. This study is focused on the synthesis of bio-adsorbent bone char to adsorbent for the removal of fluoride from groundwater obtained from Islamkot district Tharparkar. The bone char was synthesized by pyrolysis of used cow bones at a temperature of 550 degrees C. The fluoride removal efficiency of bone char was optimized. The impacts of different operating parameters such as flow rates (5mL/min, 10mL/min, and 15mL/min), bed height of adsorbent (2cm, 4cm, and 6cm), initial fluoride concentration 7.85 mg/L, and contact time (30min, 60min, and 90min) were studied. The removal efficiency was enhanced by increasing the adsorbent bed height and decreasing contact time and flow rate. With an initial concentration of fluoride 7.85mg/L, the maximum removal efficiency of 90.2% was obtained when the adsorbent bed height, flow rate, and contact time were optimized to 6 cm, 5 mL/min, and 30min, respectively. The finding showed that bone char can be used as an eco-friendly, inexpensive, and efficient adsorbent for removing fluoride from groundwater.
ANALISIS PENERAPAN AGEN46 SEBAGAI PENYEDIA LAYANAN KEUANGAN TANPA KANTOR (BRANCHLESS BANKING) DAN UPAYA PENDORONG FINANCIAL INCLUSION
Authors: Ainiyah Ghonimah Zumroatun , Nurkholik Fadilah , Kurniati Eling Ri
Published: March 2022

ABSTRACT

The development of the financial sector, especially the banking sector, can increase banking access to the public. The problem that occurred before the implementation of Agen46 was that it was difficult for people to get financial services, especially in rural communities. There are still many people who do not know, use, and get financial services, which is a complex problem. The number of Agen46 in Banjarnegara Regency is 160, while the population in Banjarnegara is 923,192 people. The comparison between the number of Agen46 and the number of residents has not met the needs of the community. Branchless banking /smart behavior, encourages banking institutions to develop financial service innovations to encourage financial inclusion. PT Bank Negara Indonesia (Persero), Tbk develops financial service innovations through Agen46. The purpose of this study was to determine the role of Agen46 in its application as a financial service without offices to meet the financial needs of the community.

This research is a type of research using a qualitative approach. The data used in this study are primary data by conducting interviews and observations at Agen46 in the Banjarnegara Regency in accordance with the research criteria. The sampling technique used in this study was purposive sampling technique, where the sampling technique took into account certain parties who were considered to meet the criteria, knew, and understood Agen46.

The results of this study indicate the role of Agen46 as a provider ofbranchless banking services for financial inclusion. The existence of agen46 is very beneficial for the people of Banjarnegara to meet their financial service needs
ANALISIS AKUNTANSI MURABAHAH PADA UJKS BMT AL-ISLAH CIREBON
Authors: ASTUTI APRI DWI , Rosiyana Tantri Dwi , Zubaedah Siti Dwi
Published: March 2022

Penelitian ini dilakukan pada BMT Al-Islah. Adapun tujuan untuk mengetahui perlakuan akuntansi murabahah tentang kesesuaian penerapan PSAK 102 yang merupakan revisi PSAK 59 di BMT Al-Islah. Dalam penelitian ini peneliti menggunakan penelitian kualitatif-deskriptif digunakan untuk menjabarkan proses pengakuan, pengukuran, penyajian dan pengungkapan transaksi murabahah pada BMT Al-Islah Cirebon. Data penelitian ini didapatkan melalui wawancara dan dokumentasi kepada pihak terkait penelitian yang diperoleh dari BMT Al-Islah Cirebon. Hasil penelitian menunjukan bahwa dalam penerapan akuntansi murabahah pada BMT Al-Islah tentang pengakuan, pengukuran, penyajian dan pengungkapan sepenuhnya sudah sesuai dengan ketentuan berdasatkan PSAK 102, walaupun ada beberapa hal yang belum sesuai dengan PSAK 102, ketidak sesuaian ada pada saat terjadi tunggakan angsuran dan penerimaan tunggakan abgsuran tidak mencatat jurnal apapun sedangkan dalam ketentuan PSAK 102 pada saat terjadi tunggakan angsuran, margin diakui proposional dengan kas yang diterima.
Efficacy of Nanocurcumin with application of Iontophoresis on Inflammatory arthritis patients.
Authors: B Nivetha. , A Rahmathunisha. , K Lokeshwari. , A Kumaresan. , K.V Sai Nikkitha. , L Yeseshivi. , R Janani.
Published: March 2022

Background: Rheumatoid arthritis (RA) is a chronic inflammatory systemic disorder that primarily affects smaller joints characterized by periods of severe pain, stiffness, and swelling and destruction of the bones and cartilage. As indicated by past investigations, oral organization of curcumin results in calming impact regardless of its low bioavailability in patients. Objective: This study aims to measure the efficacy of nanocurcumin particles with iontophoresis in inflammatory arthritis patients. Methodology: Nanocurcumin were prepared by a process based on a wet-milling technique. In vitro anti inflammatory assay of nanocurcumin was determined by Bradford assay using bovine serum albumin (BSA) as the standard. The prospective study was done among a 10 patients from the reports obtained from March 2020 to October 2020 in Physiotherapy clinic, Madurai. Results: All the curcumin-treated groups showed significant alleviation of inflammatory arthritic condition (p<0.05) when compared with inflammatory arthritic controls. Conclusion: Iontophoretic administration of curcumin may ameliorate arthritic symptoms significantly, and the effect is assumed to be due to better penetration and enhanced bioavailability. Geriatrics patients are supposed to be benefited fairly by this technique.
Molecular Docking Analysis of Compounds from Polyherbal Powder Against the Proteins Involved in Diabetes Mellitus
Authors: Sathyanarayan Sangeetha , Pillai K. Sadasivan , Udhayakumar Mythily , Subramaniam Samu
Published: March 2022

Objective: The objective of the present work is to perfom in silico docking analysis against the molecular targets involved in diabetes mellitus using active compounds from Polyherbal powder. Materials and methods: Polyherbal powder is prepared using Gymnema sylvestre, Ocimum sanctum and Azadirachta indica. Three compounds from the polyherbal powder (identified using HR-LCMS) were used for the docking against the targets (α-glucosidase, α amylase, peroxisome proliferator activated receptor gamma). Docking was performed using Autodock 4.2 software. Pymol was used for the visualization of the docking result files. Results: Binding energy of Usnic acid (-4.25 kcal/mol for 1PRG, -6.69 kcal/mol for 3WY1, -5.72 kcal/mol for 4GQQ) was low as that of standard drug Metformin (-5.07 kcal/mol for 1PRG, -6.3 kcal/mol for 3WY1, -4.02 kcal/mol for 4GQQ). Conclusion: The polyherbal powder containing the lead compounds can be used for the treatment of diabetes mellitus.
Anticancer Effect of Naringin on Human Colon Cancer (WiDr Cells):
In Vitro Study
Authors: Fadholly Amaq , Ansori Arif N. M. , Utomo Budi
Published: March 2022

Naringin, a bioflavonoid naturally found in citrus species, has been exert as promising anticancer activities. However, naringin mechanism as anticancer still remain enigmatic. This study, WiDr cell lines as human colon cancer cell in vitro were used to evaluate anticancer effect of naringin. Naringin (10, 20, 40, 60, 80µg/mL) treated on WiDr cells to evaluate IC50 value by MTT assay, then continued with analyzed caspase-3 expressions (IC50, 2IC50) as apopotosis marker. This study reported that naringin inhibit the growth of WiDr cell with IC50 value is 63.14µg/mL. The caspase-3 expressions on 2IC50 is higher (74.66%) than IC50 (56.66%). These results indicate that naringin has properties of inhibting cell growth and inducing caspase-3 expressions on WiDr cells. It is a potential compound to be developed as a chemopreventive agent for colon cancer.
Evaluation of Mucoadhesive albendazole tablets formulated using Detarium microcarpum gum
Authors: Eziuzo Okafo Sinodukoo , Afokoghene Avbunudiogba John , Benedicta Anizor Onyekachukwu
Published: March 2022

The aim of this study was to evaluate Detarium microcarpum gum (DMG) as polymer in formulated mucoadhesive albendazole tablets. FTIR studies were conducted to evaluate compatibility of DMG with albendazole. Mucoadhesive albendazole tablets were prepared by non-aqueous wet granulation technique using DMG alone (30%, 20% or 10%), in combination with carbopol (15%/15%) or carbopol alone (30%) respectively as polymers. Granules prepared were evaluated for flow rate, angle of repose, bulk and tapped density, particle size distribution, Hausner’s ratio and compressibility index. The prepared tablets were evaluated for thickness, diameter, hardness, weight uniformity, friability, drug content, dissolution, swelling studies and mucoadhesive strength. The uniformity of weight for the formulated tablets ranged from 591.1±0.011 to 601.6±0.001 mg while the drug content ranged from 98.6% to 101.3%. Tablet hardness ranged from 5.10±000 to 10.77±0.01 Kgf and friability was between 0.25±0.00 and 0.42±0.02%. The mucoadhesive strength ranged from 1.293 x 10-4 to 6.45 x 10-4. Post compression parameters were within acceptable limits. The cumulative drug release for formulations F1-F3 produced using DMG (38.52 to 54.45%) were significant improvement on that produced using carbopol (11.62%) and marketed product (8.21%). The produced tablets were stable after accelerated stability studies at 40oC and 75% relative humidity. FTIR studies indicated that DMG did not show any incompatibility with albendazole. DMG at concentration of 30%w/w could be used to produce mucoadhesive albendazole tablets with prolonged and sustained release characteristics comparable to those produced using standard polymer, carbopol.
Pharmaceutical Digital Marketing of Non-prescription Drugs: A Systematic Scoping Review
Authors: Anis Mohamad Saleem , Hassali Mohamed Azmi
Published: March 2022

There are two main purposes for this review, namely: (1) To determine key themes related to pharmaceutical digital marketing that have an impact on non-prescription drug consumers. (2) To identify if there is a knowledge gap in the non-prescription drug digital marketing literature. Four electronic databases were chosen as follows: ScienceDirect (Elsevier), Scopus, EBSCOhost, and Google Scholar, to comprehensively cover this broad research scope. A total of 498 studies were found in all databases. After they were thematically sorted, the qualitative synthesis covered 14 studies that were classified under the marketing theme. The results revealed noticeable knowledge gaps in the current literature, where four of the fourteen studies belong to the same author. Additionally, the review indicates the need to conduct further research addressing the pharmaceutical digital marketing topic and its various ramifications.
Electrochemical and gravimeter study on corrosion inhibition by (methoxymethyl) triphenylphosphonium chloride in acid media H2SO4 0.5M
Authors: Mansouri Khaled , Hellali Naima , Rahim Oumelkheir , Tabchouche Ahmed
Published: March 2022

In this work, we study the inhibitory efficacy of organometallic compounds (phosphonium salts) used as an inhibitor on the corrosion of carbon steel XC70. The compound is (methoxy methyl) triphenyl phosphonium chloride (MMTP Cl). The study was performed in a 0.5M H2SO4 media. The measurements were performed by three electrochemical methods: electrochemical impedance spectroscopy potentiodynamic polarization and gravimeter method. One of the most widely used methods of protecting metals against corrosion is the use of inhibitors. They act by adsorption on the metal surface. The effectiveness of the corrosion inhibitor has been evaluated by several methods; polarization technique (Tafel line); electrochemical impedance and mass loss spectroscopy (immersion test) in acidic media. The results have allowed us to deduce the steel corrosion rate as well as other electrochemical parameters. The overall results show that the compounds (MMTP Cl) was chemically adsorbed on the steel surface. And in this case, adsorption occurs on the surface of the metal, according to the Langmuir modelin 0.5M H2SO4 solution. And the best concentration that decreasing the corrosion rate and gives inhibitory efficacy is 1ppm (R = 74.19%). A Comparative electrochemical study with that reported in the literature revealed that the efficiency of the inhibitors follows the order: 1-butyl triphenyl phosphonium chloride> (chloromethyl) triphenyl phosphonium chloride (CTP)>tetraphenyl phosphonium chloride (TP)>triphenyl phosphine oxide (TPO) > triphenyl (phenyl methyl) phosphonium chloride (TPM). It was also reported in the literature that the efficiency of halide inhibitors follows the order: I-> Br->Cl->F-.
UV Spectrophotometric and stability indicating RP-HPLC methods for simultaneous estimation of Moxifloxacin HCl and Ketorolac tromethamine in bulk and ophthalmic dosage forms
Authors: Gayatri Alluri Pavani , Srinivas Kolli , Nageswara Rao Kavala
Published: March 2022

It was the main goal of this study's research to develop simple UV-Spectrophotometric and Stability indicating RP-HPLC methods for the simultaneous estimation of Moxifloxacin HCl (MOX) and Ketorolac Tromethamine (KET) in bulk and ophthalmic dosage forms, as well as to conduct Forced Degradation experiments. When utilising linearity ranges between 1.0 and 9.0 g/ml for MOX and KET, correlation co-efficients >0.990 were used in the UV Spectrophotometry test results. Acetonitrile (40:60 v/v) was the solvent of choice. MOX and KET were discovered to have wavelengths of 295 nm and 316 nm, respectively. Researchers discovered that the isobestic point was located at 308 nm. Both medicines were separated using RP-HPLC on a SHISHEDO C18, 2504.6mm, 5 micron size column with a mobile phase made up of 40:60 v/v acetonitrile and water with flow rate of 0.9 ml/min and UV detection at 308 nm. Moxifloxacin Hcl and Ketorolac Tromethamine had retention durations of 2.080 minutes and 4.400 minutes, respectively. Moxifloxacin Hcl and Ketorolac Tromethamine have linearities of 1.0-6.0 g/ml and 1.0-6.0 g/ml, respectively. For linearity, recovery, limit of detection, and limit of quantification statistical validation was performed on the technique. Accuracy and precision were also evaluated. Analytes are well-resolved from degradation products when medicines are subjected to a variety of stresses, such as acidic or alkaline pH values, high oxidation or photo-stability temperatures, or a combination of these circumstances. The accuracy, precision, linearity, limit of detection, limit of quantification, and robustness of the two proposed techniques were effectively validated. This means that both Moxifloxacin HCl and Ketorolac Tromethamine may be estimated simultaneously in bulk and ophthalmic dose forms using these two techniques.
Simulation of the Essential oil extraction kinetics of Xylopia aethiopica fruits from Congo Brazzaville. Fick diffusion, Peleg sorption and Michaelis-Menton enzymatic models
Authors: Bassiloua Jean Bruno , Silou Thomas , Makomo Hubert
Published: March 2022

The hydrodistillation extraction kinetics of Xylopia aethiopica fruit essential oil were modeled according to the phenomenological approach applied to Fick diffusion model, Peleg sorption model and Michaelis-Menton enzymatic model. All these models fitted experimental data. The assumptions underpining each model highlight the understanding of the process. It emerges that the essential oil releases completely at the washing step (> 90 %) with a rate constant 105 higher than those of diffusion step. This latter is the limiting step of the process. The end of the process can be estimated at 18.4 min (10t1/2) or at 36.8 min (20 t1/2) with a maximum yield varying between 3.84 and 5.09 % for the 3 studied samples. Exploring the mechanism of extraction by different complementary models improves significantly the understanding of the process and reinforces the predictive goal of this study.
Introduksi Produksi Kerupuk Cakar Ayam: Upaya Diversifikasi Hasil Samping Pemotongan Ayam
Authors: Yuanita Iis , Silitonga Lisnawaty
Published: March 2022

Diversifikasi cakar ayam sebagai produk pangan yang bermutu dan bergizi dapat meningkatkan nilai tambah hasil samping pemotongan ayam. Pengolahan kerupuk cakar ayam juga dilakukan dalam kerangka perbaikan gizi masyarakat serta alternatif sumber pendapatan dengan berbasis pada bahan baku dan proses produksi yang murah dan mudah. Tujuan dari kegiatan ini adalah membentuk kelompok usaha  kecil pembuatan kerupuk cakar ayam berbasis ibu rumah tangga serta pemberdayaan tenaga kerja wanita (ibu-ibu rumah tangga) sehingga meningkatkan pendapatan anggota kelompok industri kecil dan menjadikan lembaga perguruan tinggi sebagai sumber informasi dan perkembangan IPTEK. Metode kegiatan berupa penyuluhan dan pelatihan pembuatan kerupuk cakar ayam serta pendampingan kelompok usaha kecil pembuatan kerupuk cakar ayam berbasis rumah tangga hingga pemasarannya. Terbentuknya kelompok yang terdiri dari ibu-ibu mitra di Kelurahan Sabaru merupakan wadah pengembangan sumber daya perempuan di lokasi mitra, dimana kegiatan ini menjadi motivasi untuk memajukan potensi diri dan mengembangkan kelompoknya serta berhasil memberikan sumber pendapatan baru bagi mitra
Plantar Fasiit’ te Transvers Friksiyon Masajının Etkinliğinin İncelenmesi-Pilot Çalışma
Authors: ÇALIŞKAN Ozan Orhun , ÇITAKER Seyit
Published: March 2022

Giriş: Plantar fasiit (PF) toplumda çok sık görülen bir rahatsızlıktır. PF’de ayak tabanında ve topukta ağrı şikâyeti bulunmaktadır. Bunun sonucunda hastaların fonksiyonel düzeyleri ve günlük yaşamı olumsuz etkilenmektedir. İnsanların %10’ unu etkileyebilen bir hastalıktır. Amaç: Bugüne kadar yapılmış araştırmalarda, PF’ de transvers friksiyon masajının (TFM) yaşam kalitesine olan etkileri araştırılmamıştır. Fonksiyonel düzeye etkilerine ilişkin araştırmalarda ise anket ve ölçeklerle değerlendirme yapılmış, fonksiyonel testler ile değerlendirme yapılmamıştır. Bu çalışmanın amacı, TFM’nin PF hastalarında fonksiyonel düzey ve yaşam kalitesine olan etkilerini araştırmaktır.

Yöntem: Çalışmaya, PF tanısı almış, 3 aydır ağrısı olan yetişkin 20 hasta alınmıştır. Hastalar randomize olarak bilgisayarlı sistem ile TFM ve egzersiz grubuna ayrılmıştır. TFM grubuna (n=10) 3 hafta süresince, haftada 3 gün, 15 dakika TFM uygulanmıştır. Egzersiz grubuna (n=10) germe ve kuvvetlendirme egzersizleri 3 hafta süresince verilmiştir. Veri kayıt formu ile hastaların sosyodemografik bilgileri toplanmıştır. Ayak fonksiyonel durumu mesafeli üçlü hoplama testi ile, yaşam kalitesi ise SF-36 ölçeği ile değerlendirilmiştir. Tedaviden önce ve tedavi bitiminden 3 gün sonra bu değerlendirmeler yapılmıştır.

Bulgular: Her iki grubun sosyodemografik özellikleri benzer bulunmuştur (p>0,05). Tedavi sonrası egzersiz uygulamasının SF-36 alt parametrelerinden; fiziksel fonksiyon, fiziksel rol güçlüğü, ağrı parametrelerinde anlamlı artış sağladığı belirlenmiştir (p
Bariatrik Cerrahi Sonrası Malnütrisyonun Değerlendirilmesi ve Tedavisinde Güncel Yaklaşımlar
Authors: ALIÇ Neşe , SAMUR Gülhan
Published: March 2022

Obezitenin tedavisinde bariatrik cerrahi, uzun dönem kalıcı ağırlık kaybında ve obeziteye bağlı oluşabilecek hastalıkların tedavisinde en etkili yöntemdir. Ancak özellikle malabsorbtif etkili bariatrik prosedürler sonrası malnütrisyon ve besin ögesi eksikliklerine bağlı sağlık sorunlarının oluşması, hastaların beslenme durumunun değerlendirilmesinin önemini vurgulamaktadır. Bu derleme bariatrik cerrahi sonrası malnütrisyonun değerlendirilmesi ve tedavisinde güncel yaklaşımları incelemek amacıyla yapılmıştır. Bariatrik cerrahi hastaları prosedüre göre değişmekle birlikte besin alımında ve sindirim yolundaki fizyolojik değişimlerden dolayı beslenme açısında risklidir. Restriktif etkili; günümüzde Avustralya dışında nadiren uygulanan Ayarlanabilir Gastrik Band ve Türkiye’ de ve dünyada en çok yapılan Sleeve Gastrektomi sonrası ciddi beslenmeye bağlı komplikasyon oluşma riski malabsorbtif prosedürlere göre daha düşüktür. Malabsorbtif etkili bazı prosedürlerin emilim bozucu etkisine göre sıralaması ise şu şekildedir; Duedenal Switch > Sleeve Gastrektomi ile Tek Anastomoz Duodenal İleal Bypass/SADI > Mini Gastrik Bypass> Roux-en-Y Gastrik Bypass/RYGB. Bariatrik cerrahi sonrası görülen en yaygın besin ögesi eksiklikleri; demir, B12 vitamini, kalsiyum, D vitamini, folat, bakır ve çinkodur ancak malabsorbtif etkili prosedürlerde en ciddi komplikasyonlardan biri protein malnütrisyonudur. Kısa sürede ağırlık kaybının fazla olması, hastaya uygulanması gereken aşamalı beslenme protokolü nedeniyle malnütrisyonu değerlendirmek oldukça zordur. Hastaların hem preoperatif hemde postoperatif dönemde beslenme durumunun değerlendirilmesi, beslenmeye bağlı gelişen sağlık sorunlarının önlenmesi ve tedavisi oldukça önemlidir. Ancak bariatrik cerrahi sonrası malnütrisyonun tedavisi ve değerlendirilmesiyle ilgili spesifik indekslere ve daha kapsamlı ileri çalışmalara gereksinim vardır.
Las presunciones en el derecho
Authors: Aguiló Regla Josep
Published: March 2022

El trabajo se propone alcanzar tres objetivos. El primero es aclarar la disputada cuestión de la «naturaleza» (teórica o práctica) de las presunciones en el Derecho; el análisis que se realiza pretende separar adecuadamente las llamadas presunciones hominis (del hombre) de las presunciones establecidas por las «normas de presunción». El segundo objetivo es aclarar dos cuestiones vinculadas con las normas de presunción: una, el carácter constitutivo o regulativo de dichas normas; y, otra, si a ellas les es aplicable ladistinción entre principios y reglas. El tercer objetivo es mostrar que las llamadas «presunciones iuris et de iure» no son, en realidad, presunciones;pues el razonamiento que se genera a partir de ellas no presenta ninguna de las propiedades características del «razonamiento presuntivo».
La interpretación "a contrario" de disposiciones jurídicas
Authors: Rodríguez-Toubes Muñiz Joaquín
Published: March 2022

La interpretación a contrario de las disposiciones jurídicas es un método usual, pero problemático, de argumentar acerca del contenido del derecho. Toma la prescripción de consecuencias para un supuesto de hecho como prescripción implícita de consecuencias distintas para un caso relacionado distinto, y las hace explicitas. La justificación de este razonamiento ya sea como método de conocimiento o como argumento para motivar decisiones, depende ante todo de la solidez de la premisa que asume tácitamente. La premisa tácita es que, en ciertas condiciones y respecto de un universo de casos afines, las disposiciones tienen dos implicaciones normativas sobre supuestos que no regulan explícitamente. La implicación negativa es que nose siguen necesariamente las mismas consecuencias que en los supuestos explícitos, pero pueden seguirse si se admite la aplicación analógica de las normas. La implicación positiva es que se siguen consecuencias distintas cuando las circunstancias jurídicas o lingüísticas excluyen la analogía o cuando hay diferencias relevantes entre los casos. Esta doble premisa tiene su fundamento último en la pragmática de la comunicación jurídica. En cambio, el uso del argumento a contrario para impedir la interpretación extensiva es infundado.
La emancipación de las mujeres
Authors: Barranco Avilés María del Carmen
Published: March 2022

Por su vida y por su obra, Anna Kuliscioff constituye un ejemplo de que es posible la coherencia entre el socialismo y el feminismo. Frente a un socialismo en el que las mujeres son absorbidas por la idea de trabajador y un feminismo que pugna por amoldar la imagen de la mujer a la del titular abstracto, las propuestas de la autora son coherentes con la defensa de la igualdad en la diferencia. La reinterpretación de las ideas de Kuliscioffdesde categorías actuales permite entender que la emancipación de las mujeres no es otra cosa que el reconocimiento formal y material de su capacidad de obrar
Sobre la naturaleza de la filosofía del derecho
Authors: Domingo Pérez Tomás  de
Published: March 2022

En este trabajo se defiende una determinada posición con relación a la manera de entender la filosofía del derecho. La idea principal es que la filosofía del derecho debe tratar de comprender el sentido del derecho en sus causas últimas y dar razón de todas sus dimensiones, integrando además la historia de la filosofía del derecho. A partir de ahí se sientan las bases para acometer un proyecto de filosofía del derecho y se da cuenta de dónde se situaría el punto de partida y cuáles serían los principales objetivos del mismo.
La concepción kelseniana de los juicios de valor
Authors: Sendín Mateos José Antonio
Published: March 2022

En este trabajo pretendo realizar una exploración de la concepción kelseniana de los juicios de valor. Partiendo de un examen de su posición de escepticismo ético, que consiste en una metaética relativista desde la que él niega que se puedan fundamentar racionalmente juicios de valor morales, me ocuparé de las siguientes cuestiones: (1) un análisis crítico de la tipología de los juicios de valor que Kelsen nos ofrece en la Reine Rechtslehre, distinguiendo entre juicios de valor y juicios de realidad, y, dentro de estos, unas categorías «especiales»; (2) el problema de la valoración de las normas jurídicas a partir de normas de justicia; (3) los cambios que experimentó su concepción en la etapa final de su pensamiento, presidida por la Allgemeine Theorie der Normen; y (4) finalmente, examinaré la forma como, a su modo de ver, los juicios de valor morales y políticos pueden influir en el desarrollo de la actividad científico-jurídica, y cuál es la actitud que deben mantener los científicos del derecho hacia ellos.
V Congreso Internacional «El tiempo de los derechos» Universidad de Valladolid, 5 y 6 de noviembre de 2018
Authors: García Medina Javier
Published: March 2022

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Congreso Internacional 70 Aniversario de la Declaración Universal de los Derechos Humanos, Valencia, 10-12 de diciembre de 2018
Authors: Bea Pérez Emilia
Published: March 2022

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The Encyclical Laudato Si’ and the Overcoming of Humanism
Authors: Damour Franck
Published: March 2022

In June 2015, Pope Francis published Laudato Si’, an encyclical that, in many ways, constitutes a split. For the first time, although the magisterium of the Catholic church has, since the time of John Paul II, repeatedly expressed its views on the topic, an encyclical approached the theme of ecology and climate crisis, in the tradition of Catholic social doctrine. The break is also within ecological thought, into which Pope Francis invites himself, seeking to open another path between anthropocentrism, biocentrism, ecocentrism, and so on. The worldwide echo of its reception testifies to the novelty of the text, and also demonstrates the power of the pontifical voice in the collective imagination. In his encyclical, Francis conducts a powerful denunciation of a “techno- scientific paradigm” and its anthropocentric and Western-centric perspective. Can the pontifical voice be added to the posthumanist movement, whose horizon is inseparable from the technological changes and the environmental question? Does his criticism concern only anthropocentrism or the idea of centrality? Reading Laudato Si’ from the perspective of posthumanism debates is a way moving these debates forward.
Penggunaan Lembar Kerja Matematika Diskrit dalam Pembelajaran Daring pada Masa Pandemi Covid-19
Authors: Khairani Majidah , Roza Melia
Published: March 2022

Tujuan penelitian ini adalah untuk mengetahui masalah perkuliahan daring pada pembelajaran mata kuliah Matematika Diskrit dan untuk mengetahui solusi permasalahan pembelajaran daring mata kuliah Matematika Diskrit. Metode penelitian menggunakan metode kualitatif deskriptif. Tahapan penelitian dimulai dari perancangan penelitian melalui diskusi, penyusunan proposal, pengumpulan data, dan penyusunan laporan penelitian. Data diambil dari angket yang diisi dalam bentuk geogle drive oleh mahasiswa STKIP Ahlussunnah yang mengambil mata kuliah matematika diskrit pada semester genap 2019/2020. Hasil angket temuan masalah pembelajaran daring pada mata kuliah Matematika Diskrit terletak pada proses evaluasi pembelajaran yang belum dapat diwadahi dengan sesi diskusi/tanya jawab. Solusi yang diwarkan pada penelitian ini adalah penggunaan Lembar Matematika Kerja Diskrit. Tahapan penelitian dimulai dari perancangan penelitian melalui diskusi, penyusunan proposal, pengumpulan data, dan penyusunan laporan penelitian. Data diambil dari angket yang diisi oleh mahasiswa dan doskumentasi screenshoot dari pembelajaran daring. Hasil angket mahasiswa menunjukkan bahwa Lembar Kerja Matematika Diskrit dapat membantu mahasiswa memahami materi secara mandiri, karena LKMD menyajikan materi yang konstruktivism, disertai dengan contoh soal dan latihan.