bluuebunny/crossref_metadata_2025 huggingface dataset:
Unlocking the Potential in a Gamification-Based MOOC: Assessing Autonomous Learning and Self-Directed Learning Behaviors
Authors: Slamet Joko , Basthomi Yazid , Ivone Francisca Maria , Eliyanah Evi
Published: July 2024

Massive open online courses (MOOCs) have significantly advanced online education. Yet, MOOC instructors still grapple with the ongoing challenge of low learner engagement while striving to foster autonomous and self-directed learning (SDL). Integrating gamification into these courses could be a promising solution. However, the extent to which gamification shapes autonomous and SDL behaviors within MOOCs remains underexplored. This mixed-methods sequential explanatory study investigates the interplay between MOOC, gamification, autonomous learning, and SDL behaviors to harness the potential of online education. We address this research void by delving into the intricate relationship between gamification and learners’ engagement in autonomous learning and SDL behaviors. Drawing upon self-determination theory (SDT) as a theoretical framework, we scrutinize how gamified MOOCs influence intrinsic motivation and SDL behaviors. Our study utilizes questionnaires and structured interviews to comprehensively examine the users’ experiences within a gamified MOOC. The findings suggest that thoughtfully integrated gamification elements not only enhance learner engagement but also stimulate autonomous learning and SDL behaviors. However, it is crucial to approach the integration of gamification thoughtfully, ensuring a balance that promotes intrinsic motivation without undue reliance on extrinsic motivators. These findings hold significant implications for educators, course designers, and policymakers leveraging gamification to enrich online learning experiences and cultivate self-directed educational pathways. They offer valuable insights for educators, course designers, and policymakers aiming to leverage gamification for enriching online learning experiences and nurturing self-directed educational pathways in MOOCs.
bibliometric analysis of the top 100 most-cited articles concerning the use of propolis in dentistry
Authors: Tavares Johnny Alexandre Oliveira , Rocha Aurélio de Oliveira , Anjos Lucas Menezes dos , Cardoso Mariane , Silva Francilene Amaral da
Published: July 2024

Aim: The objective of this bibliometric analysis was to identify and analyze the key characteristics of the 100 most-cited articles related to the use of propolis in dentistry. Methods: The search was conducted in the Web of Science Core Collection, and two independent reviewers selected the articles, excluding meeting articles. The number of citations for each article was compared across the Scopus and Google Scholar databases. The extracted data included the number and density of citations, year of publication, journal and impact factor, study design and theme, country and continent, institution, keywords, and authors. VOSviewer software was employed to generate collaborative network maps. Spearman correlation and Poisson regression analyses were performed on the data. Results: The number of citations ranged from 26 to 247, with a citation density varying between 1.08 and 20.00. Articles were published between 1991 and 2021, with laboratory studies (70%) and antimicrobial activity (39%) being the most prevalent study design and theme, respectively. The most discussed dental specialty was microbiology (49%). Rosalen PL (27%) emerged as the author with the highest number of articles, and the University of Campinas (Brazil) was the most prolific institution. Poisson regression indicated a declining trend in citations over the years, though literature reviews exhibited higher citation performance. Brazil contributed the highest percentage of articles (41%). Conclusion: In conclusion, the 100 most-cited articles predominantly comprised laboratory studies investigating the antimicrobial activity of propolis, primarily originating from Brazil, with notable emphasis on the University of Campinas.
Ginástica rítmica e pedagogia do esporte
Authors: Brant Tuffy Felipe , Oliveira Laura de , Nunomura Myrian
Published: July 2024

Objetivos: descrever e revisar a literatura sobre a transversalidade entre a Pedagogia do Esporte (PE) e a Ginástica Rítmica (GR), bem como discutir e avançar com implicações práticas para essa modalidade a partir da nossa experiência profissional. Metodologia: realizamos uma revisão sistemática integrativa de artigos empíricos que explicitassem GR nas palavras-chave e se relacionassem com temas da PE. Após a análise, os artigos foram organizados em três tópicos: aspectos psicopedagógicos, formação profissional e envolvimento parental. Resultados e discussão: a revisão de sete artigos apontou a importância de adequar o ensino e treinamento às particularidades dos praticantes, estabelecer estratégias motivacionais para as práticas e relacionamentos mais positivos na GR. As principais implicações práticas identificadas foram: oportunizar experiências motoras gerais nas rotinas da GR; aumentar feedbacks positivos e diálogos com as ginastas; incentivar trabalhos coletivos; investir na qualificação de treinadores; e aproximar os pais da modalidade para favorecer o apoio mais consciente. Conclusão: apesar dos resultados promissores, este estudo selecionou apenas artigos que explicitassem GR nas palavras-chave, o que sugere a existência de muitas áreas ainda a serem exploradas no diálogo da PE com a GR.
Orlandi, E. P. Argumentação e Análise do Discurso
Authors: Assis Paloma Bianca Lopes de
Published: July 2024

O livro “Argumentação e Análise de Discurso: Conceito e Análises” de Eni Orlandi apresenta um modo teórico-discursivo materialista de pensar a argumentação. Para a autora, esse diálogo nos tempos de hoje torna-se uma questão incontornável, seja pelo avanço dos discursos totalitários, de extrema direita no Brasil e no mundo, seja pelo boom de tecnologias da linguagem e o ingresso na era digital. A obra constitui-se como um chamado à análise discursiva da argumentação, na tentativa de observar o funcionamento da ideologia dominante e compreender os novos processos de interpretação e assujeitamento, devido às mudanças sofridas na forma material da argumentação em virtude dessas novidades.
Monitoring Diesel Engines By Lube Oil Analysis (A case study )
Authors: Mohammed Ahmed Nasr
Published: July 2024

The current review focuses on monitoring oil in Diesel engines and analysis of oil to choose the right decision. The literature survey includes many cases taken to be studied to analyze the given data using experimental apparatus to get actual facts compared with the theoretical knowledge. The results will show how we can rely on this technique in monitoring, protecting, predicting the status of the engines according to the tested parameters. Oil Analysis has become an effective tool to show the clear vision of engines status. The study has applied on three cases to do the assessment and diagnose each case and construct the curves that illustrate the results for period of monitoring.
Cloud Adoption in HEIs: A Multi-Theoretical Framework Integrating TOE, TRA, and FVT
Authors: Alhazmi Abdulsalam K.
Published: July 2024

This study aims to rigorously explore cloud computing adoption in Higher Education Institutions (HEIs) by applying a detailed analytical framework. This integrates the Technology Organization Environment (TOE) Theory, the Theory of Reasoned Action, and the Fit Viability Theory to holistically examine the factors influencing such adoption, and, as such, the research uniquely emphasises the interplay between technological capabilities, organisational readiness, and environmental factors, as well as taking into account the critical aspect of cultural fit within HEIs. By synthesising these theoretical perspectives, the study provides a comprehensive understanding of the adoption process, highlighting the nuanced interactions between technology, organisation, and the broader educational environment. This approach facilitates the development of a deeper insight alongside the development of valuable guidance for effective implementation and integration strategies. The findings of this study are thus significant for educational policymakers and administrators, providing a robust framework for them to navigate the complexities of modernising educational infrastructure by applying cloud computing technologies.
Hemocoagulation Conditions Associated with Venom-Induced Consumption Coagulopathy due to Snakebite in Humans
Authors: Rinta Prasetiyanti  , Yetti Hernaningsih
Published: July 2024

Highlights:1. This review comprehensively highlighted aspects of hematologic abnormalities in snakebites, a topic that remains understudied globally.2. This review contributes insights into the field of snakebite research and improves the management of snakebites by examining the diverse effects of different types of snakebites on hemocoagulation status.
 
Abstract
Snakebite remains an underreported health hazard worldwide. The most common effects of snakebite envenomation globally are hematological disorders, with venom-induced consumption coagulopathy (VICC) being the most prevalent and significant condition. This review aimed to explore the hematological aspects of snakebite, with a focus on snakebite-induced consumption coagulopathy. We conducted a systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines through a search across several databases, namely PubMed, ScienceDirect, and Google Scholar. The inclusion criteria for this review were studies on snakebite envenomation in humans with a discussion of relevant cases. Additionally, the included studies were conducted between 2010 and 2023 and published in the English language. Studies on animal models were excluded. We used the keywords “venom-induced consumption coagulopathy AND snake" in the search. The critical appraisal was performed using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports and the Mixed Methods Appraisal Tool (MMAT). The findings were presented as a qualitative synthesis of 14 articles covering 316 patients and various snakebite types. The studies on snakebite came from various countries, but mostly from Sri Lanka. The snake types exhibited variation, with certain species existing only in specific areas. The subjects fell into different age groups, from children to the elderly. The majority of the subjects were male. The subjects' youngest age was 6 years old, while the oldest was 70 years old. Prothrombin time (PT) and activated partial thromboplastin time (APTT) were the most discussed variables. Some of the studies demonstrated an increase in PT and APTT, although other studies reported contrasting findings. In conclusion, certain types of snakebite have a different impact on the hemocoagulation status.
Screening of Tuberculosis Infection through Acid-Fast Bacilli Tests among Waste Workers in Gresik, Indonesia
Authors: Budi Utomo  , Widati Fatmaningrum  , Sulistiawati  , Shifa Fauziyah  , Chan Chow Khuen  , Nur Fadhilah  , Teguh Hari Sucipto
Published: July 2024

Highlights:
1. This study was the first in Gresik, Indonesia, to conduct mass screening of tuberculosis among waste workers, comprising various demographic profiles.2. Although the tuberculosis screening of the waste workers showed negative results, mass examination using an acid-fast bacilli smear remains crucial to detect latent infections and prevent transmissions.
 
Abstract
Tuberculosis is a major source of illness and mortality worldwide. Therefore, tuberculosis screening is important to increase the number of active case-finding in a community. Bacteriological examinations can be used to initiate community-based active case-finding. Waste workers face a high risk of contracting Mycobacterium tuberculosis due to their constant exposure to waste. This study aimed to conduct bacteriological examinations to identify tuberculosis infections among waste workers in Gresik, Indonesia, who were considered a high-risk group. An analytical observational study was carried out throughout September 2023 in the Ngipik subdistrict, Gresik, East Java, Indonesia. The primary study was conducted using a cross-sectional design using interviews, measurements, and sputum examinations for all samples. The screening involved a total of 72 waste workers who had daily contact with various types of sewage and waste, including medical waste. The data were analyzed descriptively because of the constant variable. Following the analysis, the data were presented using a table and a figure. According to the acid-fast bacilli examinations, all of the samples yielded negative results. Nevertheless, this study concludes that it is imperative to carry out mass tuberculosis screening in various settings, specifically among those with a high risk. Mass screening can uncover the potential of latent tuberculosis and, thus, reduce its transmission.
PERINEUM MASSAGE EDUCATION TO EMPOWER PREGNANT WOMEN IN PREVENTING PERINEAL RUPTURE AT PENELEH PUBLICH HEALTH CENTER SURABAYA 2023
Authors: Kurniawati Eighty Mardiyan , Hardianto Gatut , Wahyuningtyas Riska , Rahmawati Nur Anisah , Mustofa Vina Firmanty , Safitri Cahyani Tiara , Kurniawan Agde Muzaky , Rustam Mardianti
Published: July 2024

The three highest causes of maternal death in Indonesia, which is bleeding. Severe perineal rupture or what is called OASIS can cause bleeding that can lead to death. This community service activity aims to provide education about perineal massage to empower pregnant women to prevent perineal rupture at the Peneleh Public Health Center, Surabaya in 2023. Partnership programs are needed to achieve the Sustainable Development Goals (SDGs) targets. The problem faced by partners is that even though pregnancy classes are running, they do not yet provide material on preventing perineal rupture and practicing perineal massage so mothers do not have an understanding of techniques for preventing perineal rupture. Apart from that, health workers have not mastered perineal massage techniques so they cannot provide their knowledge to pregnant women. Activities are carried out in the form of providing material and practice. The evaluation was carried out by administering a pretest and posttest for knowledge and assessment of perineal massage skills for pregnant women and health workers. The evaluation method used was the ability of pregnant women to perform phantom perineal massage exercises. Pregnant women are said to be able to do this if they can do it correctly. Providing education related to perineal massage can increase the knowledge and skills of pregnant women thereby supporting the prevention of bleeding. Suggestions for community health centers to improve education so that pregnant women are ready to do it independently at home and provide support to health workers to provide education to pregnant women.
OPTIMIZING THE GROWTH AND DEVELOPMENT OF TODDLERS THROUGH EMPOWERING CADRES AND MOTHERS OF TODDLERS WITH ASIKIA ACTIVITIES
Authors: Yuliawati Dwi , Sheilla Tania Marcelina
Published: July 2024

The toddler period is a vulnerable time, especially with regard to growth, as it can affect the development of children in the future. Therefore, it is necessary to intervene to increase the interaction of health professionals with parents to have a positive impact on child development. The Maternal and Child Health Information Sharing Agenda (ASIKIA) is an activity carried out in an effort to empower the community, especially cadres and mothers of toddlers in optimizing the growth and development of infants and toddlers. Community empowerment activities were carried out through cadre mentoring activities on March 14, 2023 and toddler mother class activities on March 16, 2023. The empowerment model used is Unlimited Totality Health Empowerement (UTHE) which uses several kinds of models in activities in the form of lectures, group discussions, demonstrations and discussions. The activities carried out proved to be able to increase the knowledge of cadres about stimulation of growth and development of toddlers as shown by the results of the pre-test and post-test where before being given counseling, cadre knowledge in the good category was 50% and after being given counseling cadre knowledge increased to the good category as much as 88%. Likewise, the knowledge of mothers of toddlers about stunting showed results before being given counseling, the knowledge of mothers of toddlers in the good category was 17% and after being given counseling, the knowledge of mothers of toddlers increased to the good category by 100%. In addition, the success of the activity is also indicated by the ability of cadres to correctly assess child development using the "SIP (Developmental Stimulation) Bag" media. ASIKIA can be used as a means of sharing knowledge and active discussion between the service team and activity participants on various maternal and child health issues.
Two new records of fairy lanterns, Thismia (Thismiaceae) for the Flora of Laos
Authors: Phonepaseuth Phongphayboun ,   Faculty of Environmental Sciences, National University of Laos, Dongdok Campus, Xaythany District, Vientiane Capital, Laos, Vuong Truong Ba , Souladeth Phetlasy , Yamamoto Takenori , Vongthavone Thyraphon , Kongxaisavath Deuanta , Trong Pham Quoc , Tagane Shuichiro ,   Institute of Tropical Biology, Vietnam Academy of Science and Technology, Vietnam,   Faculty of Forest Science, National University of Laos, Dongdok Campus, Xaythany District, Vientiane Capital, Laos,   The Kagoshima University Museum, Kagoshima University, 1-21-30 Korimoto, Kagoshima 890-0065, Japan,   Association for Community Development (ACD), Salavan Province, Laos,   Faculty of Forest Science, National University of Laos, Dongdok Campus, Xaythany District, Vientiane Capital, Laos,   Institute of Tropical Biology, Vietnam Academy of Science and Technology, Vietnam,   The Kagoshima University Museum, Kagoshima University, 1-21-30 Korimoto, Kagoshima 890-0065, Japan
Published: July 2024

Two species of the genus Thismia (Thismiaceae), T. angustimitra and T. javanica, from Nam Kading National Protected Area, central Laos, are recorded for Lao flora for the first time. The number of species of Thismia in Laos is raised to three, and a key to species of Thismia in Laos is provided.
Short-Term Power Load Forecasting Method Based on GRU-Transformer Combined Neural Network Model
Authors: Mao Weiwei , Yu Suping , Chen Wenqing
Published: July 2024

Load Forecast (LF) is an important task in the planning, control and application of public power systems. Accurate Short Term Load Forecast (STLF) is the premise of safe and economical operation of a power system. In the research of short-term power load forecasting, machine learning and deep learning are the most popular methods at present, but there still exists a problem that the single and simple structure of power load forecasting model leads to low accuracy of load forecasting. In order to improve the accuracy of STLF, a Gated Cycle Unit (GRU)-Transformer combined neural network model is proposed. Transformer encoder structure is used as feature extractor to mine the complex mapping relationships between the input features and load. The advantage of self-attention mechanism is used to solve the problem of information loss of long sequences in short-term power load forecasting. At the same time, the multivariate time series model of GRU is used for model training. The experimental results on the power load data set of a certain region in southwest China and Panama City show that the proposed combined model prediction method has higher accuracy than those proposed in other literatures, which further proves its feasibility and superiority.
High-Frequency Quantitative Trading of Digital Currencies Based on Fusion of Deep Reinforcement Learning Models with Evolutionary Strategies
Authors: He Yijun , Xu Bo , Su Xinpu
Published: July 2024

High-frequency quantitative trading in the emerging digital currency market poses unique challenges due to the lack of established methods for extracting trading information. This paper proposes a deep evolutionary reinforcement learning (DERL) model that combines deep reinforcement learning with evolutionary strategies to address these challenges. Reinforcement learning is applied to data cleaning and factor extraction from a high-frequency, microscopic viewpoint to quantitatively explain the supply and demand imbalance and to create trading strategies. In order to determine whether the algorithm can successfully extract the significant hidden features in the factors when faced with large and complex high-frequency factors, this paper trains the agent in reinforcement learning using three different learning algorithms, including Q-learning, evolutionary strategies, and policy gradient. The experimental dataset, which contains data on sharp up, sharp down, and continuous oscillation situations, was chosen to test Bitcoin in January-February, September, and November of 2022. According to the experimental results, the evolutionary strategies algorithm achieved returns of 59.18%, 25.14%, and 22.72%, respectively. The results demonstrate that deep reinforcement learning based on the evolutionary strategies outperforms Q-learning and policy gradient concerning risk resistance and return capability. The proposed approach offers a robust and adaptive solution for high-frequency trading in the digital currency market, contributing to the development of effective quantitative trading strategies.
Aleksander Dubiski (1886-1939) – a doctor and participant in the Wielkopolska Uprising
Authors: Sukiennicki Antoni
Published: July 2024

Aleksander Dubiski (1886-1939), ukończył studia lekarskie w Monachium, po czym podjął pracę w Szpitalu Sióstr Elżbietanek w Poznaniu. Po wybuchu I wojny światowej został zmobilizowany do armii pruskiej i skierowany do pracy w szpitalu wojskowym w Ostrowie Wielkopolskim. Po zakończeniu wojny, brał udział w powstaniu wielkopolskim i wojnie bolszewickiej. Po odzyskaniu przez Polskę niepodległości kierował oddziałem chirurgicznym i był dyrektorem powiatowego szpitala w Ostrowie Wielkopolskim. Po wybuchu II wojny światowej został aresztowany przez Niemców i rozstrzelany
NEURO-REGULATOR WITH SIMPLIFIED STRUCTURE FOR ELECTRIC DRIVE WITH FRICTION LOAD
Authors: Klepikov Vladimir , Bieliaiev Oleh
Published: July 2024

A controller for electromechanical electric drive systems based on the structure of the output neuron is proposed. In contrast to the synthesis of a traditional neural network of a neurocontroller, for the proposed regulator, the finding of weighting coefficients, which require multiple iterative computer calculations, is excluded. They are determined by derived analytical ratios. Compared to the modal controller, for which it is necessary to measure a number of coordinates of the electric drive, including those that are difficult to measure, in the proposed one, you can limit yourself to the measurement of only one output coordinate. For a linear system, one output neuron is enough, for a nonlinear system, their number is equal to the number of sections that linearize the nonlinearity.
METHODOLOGICAL PRINCIPLES OF MONITORING INDICATORS OF ENERGY SECURITY IN THE ACTIVITIES OF BUSINESS STRUCTURES
Authors: Kobeleva T. , Pererva P.
Published: July 2024

The article proves that the energy security monitoring system of business structures is an effective tool for monitoring and ensuring the normal functioning of various types of economic objects and processes. This economic category has been used for a long time and quite widely in the field of production and business activity of industrial enterprises. In order to increase the efficiency of the economy, along with the reforms carried out at the macro level, it is necessary to reform the activities of individual enterprises as subjects of the micro level. At the same time, the role and significance of the management component of the functioning of industrial enterprises is determined, based on the analysis of the information received by the enterprise and the monitoring of production, sales and management processes. A methodical approach to monitoring the energy security of business structures has been developed. An analytical monitoring function is proposed, which can be sufficiently objective to reflect the existence of economic security at the enterprise. The theoretical and methodical foundations of energy security monitoring, which are based on production, commercial and financial performance indicators of the enterprise, are considered. Existing monitoring systems consider its possibilities extremely broadly, including anti-crisis, environmental, financial, innovative and other types of monitoring. It is proven that the theory and practice of economic monitoring does not sufficiently illuminate its possibilities in relation to industrial and commercial activity. A meaningful sequence of stages of monitoring financial and production and commercial activity of an industrial enterprise is proposed. It has been proven that an enterprise's assessment of its commercial opportunities, the state of its target market, economic changes in it, the determination of its position on the market in relation to similar goods and substitute goods, and the determination of possible prospects and directions of innovative development can be carried out quite effectively using the principles and methods of economic monitoring. Methodical provisions for monitoring the energy security of an industrial enterprise have been developed. with the use of monitoring functions. The proposed function is defined in the interval [-1; +1] and due to its non-linearity, it becomes possible to track the gradient of changes in the energy security results of the enterprise. The size of this change is the basis for monitoring the level of energy security of an industrial enterprise.
THE ROLE OF FINANCIAL POTENTIAL IN THE MODERN CONCEPT OF COMPETITIVE ENTERPRISE MANAGEMENT
Authors: Mishchenko Volodymyr , Shapran Evgen , Daragan Anton , Drugova Olena
Published: July 2024

The article defines the main features of modern company management, which include: anti-crisis, innovativeness, value orientation, controlling. The need to take these features into account when forming and realizing the financial potential as a component of the economic potential of the enterprise is described. It is proposed to form a separate innovation and investment potential along with other types of potential. At the same time, the financial potential ensures continuous innovativeness precisely because of the most dynamic innovation-investment potential with its intellectual component, thereby ensuring the constant competitive advantages of the enterprise. The interaction between financial and economic potential is described through the model of a balanced scorecard, which takes into account non-financial indicators and makes it possible to assess the contribution to the financial result and the potential of various resources of the enterprise.
ARTIFICIAL INTELLIGENCE AND HUMANITY
Authors: Kuklin V. , Ivin L. , Mekhovych S.
Published: July 2024

The phenomenon of the cognitive revolution in the field of artificial intelligence is considered. It turned out that large language models, taking into account auxiliary systems-plugins, already significantly exceeded the intellectual capabilities of not only average intellectuals, but in general the intellectual capabilities of a significant number of specialists in most fields of activity. The analogy of these transformations with the processes of emergence of the second signal system of humanity is shown. People's fears are connected not only with their removal from jobs in most industries, but also with the possibility of a revolution of robots, which are generally able to push humanity to the sidelines. Although among the elites, who no longer meet modern requirements, there are many supporters of using artificial intelligence for enrichment, creating new weapons, and solving infrastructure problems. Recently, there has been an active discussion in the scientific community and government circles about threats to humanity from artificial intelligence (AI). There are fears that artificial intelligence may put too many people out of work too quickly, and chat rooms like ChatGPT and Bard may spread inaccurate or misinformation, violate copyright, generate fakes in both audio and video formats. Other thoughts and suggestions to do a pause in scientific research on AI. At first glance, this does not bother us so much, let civilization develop in the direction of using new opportunities. But history teaches us. Look at how people are not very rational with atomic energy, chemistry, genetics and pharmacopoeia, where it is difficult but necessary to create restrictions and safeguards. Until humanity learns to create a new type of elite, which would be able to carefully and carefully approach the use of the achievements of progress, all these safeguards will be ineffective. The problem intersects with insufficient efforts in scientific and applied fields not so much in artificial intelligence, but rather in sociology, attempts to find answers in the future (futurism) and in political science.
Penerapan Integrated Marketing Communication (IMC) di Situs Judi Online Bandar55
Authors: Alvin Silvanus
Published: July 2024

Praktik judi online termasuk illegal di Indonesia. Undang-Undang yang melarang judi telah berisi sanksi tegas, mulai dari hukuman pidana dan denda dalam nominal besar. Meski demikian, judi online tidak pernah kehabisan pemain. Berangkat dari fenomena tersebut, peneliti berusaha mengetahui strategi komunikasi seperti apa yang dilakukan bandar judi online dalam menjaring penjudi baru dan mempertahankan para penjudinya. Objek dari penelitian ini adalah situs judi online, Bandar55 yang server pusatnya berada di Kamboja dan memiliki mayoritas pekerja yang berasal dari Indonesia. Penelitian ini termasuk kualitatif dengan pendekatan studi kasus. Data penelitian ini didapat dari dua informan kunci yang merupakan mantan customer service (CS) di Bandar55 yang bertugas mencari penjudi baru. Data diperoleh menggunakan wawancara mendalam. Hasil dari penelitian ini menyimpulkan Bandar55 telah membentuk skema taktis dan menerapkan Intergated Marketing Communication (IMC) sebagai fondasinya, seperti direct marketing, sales promotion, personal selling, interactive marketing, advertising, dan word of mouth. Temuan lainnya yang tidak kalah menarik adalah IMC yang dilakukan Bandar55 berlandaskan informasi palsu dan manipulatif, dengan tujuan utama mengelabuhui individu untuk berjudi dan tidak bisa lepas dari praktik illegal ini.
Revolutionizing Efficiency: Gan-augmented Training for Lightweight Image Recognition
Authors: Korla Jayanthi , Yenni Priyanka , Sunkara Venkata Sai Prasad
Published: July 2024

In the world of computer science, image recognition is a vital area that uses complex algorithms to make machines able to understand and classify visual data. The technology has applications in many fields including artificial intelligence, computer vision and others as it offers solutions for automated systems, security and object detection. This paper uses LaPlace GAN for image clarity enhancement and SSD (Single Shot MultiBox Detector) for effective object detection using one shot learning. By employing the strengths of LaPlace GAN, the model concentrates on improvement of intricate details and minimization of noise that leads to significant increase in overall clarity of an image. In addition, integration of SSD allows real time object detection hence the system can identify multiple objects simultaneously within a single step. Through training images from both PASCAL VOC2007 and PASCAL VOC2012 datasets, this research shows improved model performance. For training, proposed framework combines union of PASCAL VOC2007 train and VOC2012 trainval images; validation set is composed of PASCAL VOC2007val images while testing will be done with Pascal’s 2007 test images. The assessment gauge contains the Average Precision (AP) and mean Average Precision (mAP) calculated for all 20 classes that have been annotated in line with the PASCAL VOC object detection evaluation protocol.
Soil eutrophication induces distinct responses in Brazilian savanna’s tree species and affects ecological interactions
Authors: Tinoco Carla Faleiro , Castro Sílvia , Daud Rodrigo Damasco , Falchi Vanessa Leonel , Reis Júlia Almeida , Constantino Stefany Ribeiro , Neto Carlos de Melo e Silva , Carvalheiro Luísa Gigante
Published: July 2024

Human-induced changes in global biogeochemical cycles, particularly in nitrogen (N) and phosphorus (P) flows, significantly impact plant growth and nutritional composition, thereby affecting ecosystem dynamics. However, research on effects of increased nutrient availability often focuses on primary producers community level effects, overlooking interspecific variability and neglecting impacts on higher trophic levels. Using a controlled fertilization experiment with six tree species native to Cerrado (Brazilian savannas) we showed that there is significant interspecific variation in how plant biomass responded to nutrient changes, indicating competitive advantages for certain native species under a scenario of soil eutrophication. We also show that such effects propagated to higher trophic levels (herbivores and their predators), also varying between plant host species. The strength and direction of N input effect of depended on P levels and the type of herbivores. Large invertebrate leaf-herbivores were less affected that phytophagous mites. Impacts on higher trophic levels (predatory mites) were less pronounced than on phytophagous mites. In summary, ongoing soil eutrophication has the potential to alter interspecific competition dynamics in plant communities with consequences for ecological interaction partners. These findings have important implications for conservation and ecosystem management, especially in areas highly exposed to soil eutrophication due to farming and industral activities.
Application of GALDIT Approach for Sea water intrusion vulnerability assessment: A case study of Bhubaneswar and Puri city, Odisha
Authors: Sarangi Manorama , Kar Anil Kumar , Lohani Anil Kumar
Published: July 2024

Sea water intrusion is a growing concern for coastal and nearby areas. The application of ground water and its over exploitation is the main cause of sea water intrusion. Ground water is being pumped from the aquifers and those aquifers are hydraulically connected with sea. The pumping induces a hydraulic gradient which cause the moving of sea water towards ground water in that excessive pumping area and it aggravates due to reduction of fresh water inflows. As the use of pure ground water is highly essential for developmental uses, it is necessary to determine the sea water intrusion particularly for coastal areas and its nearby cities. The spatial distribution of sea water intrusion of Bhubaneswar city and the coastal city Puri, Odisha is identified here in this research. The vulnerability of sea water intrusion has been studied at Bhubaneswar city, the capital of Odisha, India including the coastal city Puri, using GIS based GALDIT method. The six important factors are Ground water occurrence (G); Aquifer Hydraulic Conductivity (A); Depth of ground water Level above mean sea level (L); Distance from Shore (D); Impact of existing sea water intrusion (I); Aquifer Thickness (T) are taken into consideration. The data are ranked and different weights and ratings are allocated as per their contribution to salination and the thematic maps are overlayed using GIS in order to make the vulnerability analysis. The study shows that, the Bhubaneswar city has very less vulnerability to sea water intrusion up to the time period of analysis. But Puri district has high vulnerable to sea water intrusion. Here also the sensitivity analysis is performed to have a proper knowledge about the most and least sensitive parameter for the sea water intrusion using map removal sensitivity analysis.
Comparison of the Amyloid Plaque Proteome in Down Syndrome, Early-Onset Alzheimer’s Disease and Late-Onset Alzheimer’s Disease
Authors: Martá-Ariza Mitchell , Leitner Dominique F , Kanshin Evgeny , Suazo Jianina , Pedrosa Ana Giusti , Thierry Manon , Lee Edward B. , Devinsky Orrin , Drummond Eleanor , Fortea Juan , Lleó Alberto , Ueberheide Beatrix , Wisniewski Thomas
Published: July 2024

Background Down syndrome (DS) is strongly associated with Alzheimer’s disease (AD), attributable to APP overexpression. DS exhibits Amyloid-β (Aβ) and Tau pathology similar to early-onset AD (EOAD) and late-onset AD (LOAD). The study aimed to evaluate the Aβ plaque proteome of DS, EOAD and LOAD.Methods Using unbiased localized proteomics, we analyzed amyloid plaques and adjacent plaque-devoid tissue (‘non-plaque’) from post-mortem paraffin-embedded tissues in four cohorts (n = 20/group): DS (59.8 ± 4.99 y/o), EOAD (63 ± 4.07 y/o), LOAD (82.1 ± 6.37 y/o) and controls (66.4 ± 13.04). We assessed functional associations using Gene Ontology (GO) enrichment and protein interaction networks.Results We identified differentially abundant Aβ plaque proteins vs. non-plaques (FDR < 5%, fold-change > 1.5) in DS (n = 132), EOAD (n = 192) and in LOAD (n = 128); there were 43 plaque-associated proteins shared between all groups. Positive correlations (p < 0.0001) were observed between plaque-associated proteins in DS and EOAD (R2 = 0.77), DS and LOAD (R2 = 0.73), and EOAD vs. LOAD (R2 = 0.67). Top Biological process (BP) GO terms (p < 0.0001) included lysosomal transport for DS, immune system regulation for EOAD, and lysosome organization for LOAD. Protein networks revealed a plaque enriched signature across all cohorts involving APP metabolism, immune response, and lysosomal functions. In DS, EOAD and LOAD non-plaque vs. control tissue, we identified 263, 269, and 301 differentially abundant proteins, including 65 altered non-plaque proteins across all cohorts. Differentially abundant non-plaque proteins in DS showed a significant (p < 0.0001) but weaker positive correlation with EOAD (R2 = 0.59) and LOAD (R2 = 0.33) compared to the stronger correlation between EOAD and LOAD (R2 = 0.79). The top BP GO term for all groups was chromatin remodeling (DS p = 0.0013, EOAD p = 5.79x10− 9, and LOAD p = 1.69x10− 10). Additional GO terms for DS included extracellular matrix (p = 0.0068), while EOAD and LOAD were associated with protein-DNA complexes and gene expression regulation (p < 0.0001).Conclusions We found strong similarities among the Aβ plaque proteomes in individuals with DS, EOAD and LOAD, and a robust association between the plaque proteomes and lysosomal and immune-related pathways. Further, non-plaque proteomes highlighted altered pathways related to chromatin structure and extracellular matrix (ECM), the latter particularly associated with DS. We identified novel Aβ plaque proteins, which may serve as biomarkers or therapeutic targets.
Clinical Significance of Dynamic Monitoring of EVI1 Gene Expression in Pediatric Acute Myeloid Leukemia
Authors: Zhang Lan-Nan , Li Jian-Xin , Wang Zhuo , Yang Li , Chen Zhi , Tao Fang , Wu Sha , Lu Wen-Jie , Sun Ming , Qi Shan-Shan , Zheng Zhong-Zheng , Xiong Hao
Published: July 2024

Objective
To investigate the clinical significance of dynamic monitoring ecotropic virus integration site-1 (EVI1) expression in childhood acute myeloid leukemia (AML).
Methods
A retrospective analysis was conducted on 113 pediatric AML patients of Wuhan Children's Hospital from 2014 to 2022. The correlation between EVI1 expression levels and clinical indicators including clinical characteristics, first complete remission (CR1), relapse, and overall survival (OS) was analyzed. Receiver operating characteristic (ROC) curve analysis was carried out to comprehend the influence of EVI1 expression on relapse.
Results
A total of 78 AML children with EVI1 expression at initial diagnosis were eligible, divided into EVI1-positive (EVI1high) and EVI1-negative (EVI1low) groups. FAB classification (P = 0.047) and abnormal karyotype (P = 0.009) showed significant differences between the two groups. The proportion of EVI1 high in individuals with complex and/or monomeric karyotypes was significantly higher than in other cases (P = 0.032). When completing the first induction therapy, the EVI1high group showed a significantly lower CR1 rate than the EVI1low group (P = 0.015). Among 51 cases with EVI1 expression dynamically monitored, those with EVI1 overexpression more than twice had significantly shorter OS (P < 0.05). Among 19 non-HSCT patients undergoing three EVI1 assessments during induction therapy, those with EVI1 overexpression over once had higher relapse rates (P = 0.045). In addition, EVI1 expression level ≥ 83.38% significantly predicted relapse (AUC = 0.833).
Conclusion
Aberrantly high expression of EVI1 in pediatric AML was associated with poor prognosis. Continuous and dynamic monitoring of EVI1 expression promotes prognostic evaluation. We add some insights into the impact of EVI1 on the AML patients’ OS and survival.
Enhancing Ras Cheese Safety: Antifungal Effects of Nisin and its Nanoparticles Against Aspergillus flavus
Authors: Elhamed Esraa Yousef Abd , El-Bassiony Tawfik Abd El-Rahman , Elsherif Wallaa Mahmoud , Shaker Eman Mokhtar
Published: July 2024

Background Due to adverse effects of industrial chemicals and their carcinogenicity and toxicity for humans, the debates have increased on using natural preservatives. This study was conducted to investigate the inhibitory effect of pure nisin and nisin nanoparticles (nisin NPs) against Aspergillus flavus which was inoculated in laboratory manufactured Ras cheese. A novel, safe, and natural approach of nanoprecipitation utilizing acetic acid was used to create nisin nanoparticles. The prepared NPs were characterized using zeta-sizer, FTIR and transmission electron microscopy (TEM). Furthermore, an evaluation of nisin NPs' cytotoxicity on Vero cells was conducted. The minimum inhibitory concentrations (MICs) of nisin and its nanoparticles were detected in-vitro against A. flavus isolates using agar well-diffusion method.
Results The obtained results showed a strong antifungal activity of nisin NPs (3.125%) against A. flavus strain in comparison with pure nisin. Notably, the count decreased gradually by time from 2×108 at zero time and could not be detected at 7th week. While the count with pure nisin decreased from 2×108 at zero time and could not be detected at 10th week where it’s enough time to produce aflatoxins in cheese. Additionally, the sensory parameters of the manufactured Ras cheese inoculated with nisin and nisin NPs were of high overall acceptability (OAA).
Conclusions Overall, the results of this study suggested that adding more concentration from nisin nanoparticles during the production of Ras cheese may be a helpful strategy for food preservation against A. flavus in the dairy industry.
Venous Thromboembolic Events Following Revisional Gastric Bypass: An Analysis of the MBSAQIP Database From 2015 to 2019 Using Propensity Matching
Authors: Economopoulos Konstantinos P. , Szoka Nova , Eckhouse Shaina R. , Chumakova-Orin Maryna , Kuchibhatla Maragatha , Merchant James , Seymour Keri A.
Published: July 2024

Background
Primary bariatric surgery is associated with moderate to high risk of venous thromboembolic events (VTE), however the risk for revisional surgery lacks granularity. Our primary objective was to define the risk of VTE following revisional Roux-en-Y gastric bypass (RYGB) compared to primary RYGB.
Methods
Adults who underwent primary or revision/conversion RYGB between January 1, 2015 and December 31, 2019 with a BMI ≥ 35 kg/m2 were identified in a bariatric specific database. VTE was defined as pulmonary embolus and/or deep venous thrombosis. 30-day VTE and transfusion rates were compared between the two groups using propensity score matching of 3:1.
Results
Primary RYGB was performed in 197,186 (92.4%) patients compared to 16,144 (7.6%) in the revisional group. Patients in the revisional group had fewer comorbidities than those undergoing primary RYGB. In the matched cohort of 64,258 procedures, there were 48,116 (74.9%) primary RYGB cases compared to 16,142 (25.1%) RYGB revisions. The rate of VTE was similar in the revisional surgery group compared to the propensity matched primary RYGB group (0.4% vs. 0.3%, p > 0.580), however transfusion was more common in the revisional group (1.4% vs. 1.0%, p = 0.005). Revisional group had higher rates of readmission, reoperation, increased length of stay and operation length ≥ 180 minutes compared to matched primary RYGB group (p < 0 .001).
Conclusions
VTE rates for both primary and revisional RYGB are similar. Revisional RYGB cases impose increased risk of bleeding amongst other outcomes. Thus, identifying those at higher risk of complications is critical.
The Impact of Remimazolam on Hypoxemia in Elderly Patients Undergoing Flexible Bronchoscopy: A Prospective Cohort Study
Authors: Ma Dongmei , Li Li , Han Fuyi , Chen Ping , He Jiannan , Xu Jianhong
Published: July 2024

Background
The elderly are at a higher risk of hypoxemia during flexible bronchoscopy due to the complexity of the procedure and the need for adequate anesthesia and sedation. This prospective cohort study aimed to estimate whether remimazolam can reduce the incidence of hypoxemia during flexible bronchoscopy in elderly patients.
Methods
The elderly patients who underwent fiberoptic bronchoscopy were enrolled in this prospective cohort study. We evaluated the incidence of hypoxemia during bronchoscopy with remimazolam exposed vs propofol. Exposed group patients received remimazolam 0.15mg/kg i.v followed 1mg/kg/hr. infusion, and non-exposed group patients received propofol 1mg/kg i.v followed 4-6mg/kg/hr. infusion. The incidence rates of hypoxemia, severe hypoxemia, fully alert time, and adverse effects in both groups were compared.
Results
In the exposed group, a hypoxemia prevalence of 29.42% was observed compared to 60.00% in the non-exposed group (OR 2.10, 95% CI 1.18–3.74, P = 0.017) prior to controlling for potential confounding variables. Similarly, the overall incidence of severe hypoxemia was 24.64%, with a lower incidence in the exposed group compared to the non-exposed group (11.76% vs. 37.14%, OR 2.10, 95% CI 1.18–3.74, P = 0.017) before adjusting for confounding factors. In either group, hypotension, bradycardia, or hypopnea were not significantly different. The incidence of hypotension was 17.65%, with a lower occurrence in the exposed group compared to the non-exposed group (17.65% vs. 37.14%, P = 0.0699), suggesting a trend towards clinical significance despite the small sample size. Remimazolam exposure exhibited a lower risk of hypoxemia in comparison to propofol (OR 0.16, 95% CI 0.04–0.64, P = 0.010). Additionally, smoking was found to be associated with a reduced risk of hypoxemia when compared to non-smoking (OR 0.008, 95% CI 0.01–0.51, P = 0.008).
Conclusion
This observational cohort study suggests that elderly patients undergoing FB may benefit from remimazolam sedative anesthesia, which reduces hypoxemia. Remimazolam is a safer solution than propofol for elderly patients undergoing FB.
Trial registration
Clinicaltrails.gov Retrospectively registered (ChiCTR2300071137 Registration date05/05, 2023)