bluuebunny/crossref_metadata_2025 huggingface dataset:
Space and meanings in the artistic and imaginative representation of Belarusian literature
Authors: Shaladonava Zh. S.
Published: February 2025

The analysis of the experience of space exploration allows us to note a stable tendency of filling spatial objects and phenomena with meanings and their subsequent perception as signs of human spirituality and culture. As a result of the semantics study of the space images in the works of Belarusian literature, their spiritual and aesthetic essence and symbolic content are revealed. For the first time in Belorussian literary criticism at studying the polyvalent phenomenon of spatiality in literary works, aesthetic vision of the authors, philosophical depth of their reflections, and the desire to understand civilizational and cultural logic of the society development are problematically combined. Such methods of artistic space modeling provide us an opportunity to demonstrate its image resources in the geopoeticization of the people and the country, the embodiment of national axiology, moral and ethical ideals and existential meanings. The identification of ideological and semantic content of spacial images in the works of Ya. Kupala, Ya. Kolas, M. Tank, I. Shamyakin, V. Gnilomedov allows us to reveal the techniques and methods of creative development of the surrounding world by writers, the embodiment of the fundamental principles of the national lifestyle and the reflection of evolutionary processes in society, revealing the spirituality of the Belarusian, the specifics of his thinking and worldview. New approaches to understanding the essence of man through the ontology of space and its figurative and symbolic embodiment in Belarusian classics are demonstrated in the study.
Superhydrophobic and oleophobic composite coatings based on silicon dioxide nanoparticles and polyethyl cyanoacrylate
Authors: Salamianski A. E. , Akulova V. M. , Melnikova G. B. , Huryna Z. S. , Sinkevitch Yu. V. , Agabekov V. E.
Published: February 2025

Composite coatings of silicon dioxide nanoparticles of polyethylcyanoacrylate and heptadecafluorotetra hydrodecyltriethoxysilane oligomers obtained on steel and silicon substrates by spin coating method. The highest values of the water contact angle are 150° and 151° with a wetting hysteresis less than 2.0° and hexadecane contact angle 125.6° ± 1.5° и 126.0° ± 2.0° for coatings obtained on silicon and steel surfaces, respectively, from a suspension containing 6.6 mass.% SiO2 nanoparticles in ethylcyanoacrylate.
Influence of carbon support action on the deposited palladium electronic and structural characteristics
Authors: Khaminets S. G. , Matveichuk S. V. , Tychinskaya L. Yu.
Published: February 2025

The structural characteristics and electronic state of palladium deposited on carbon fiber materials (Busofit, Carbopon) and the carbon composite Sibunit were studied. The study of supports and Pd/C composites by modern instrumental methods (AES-ICP, TEM, EXAFS- and X-ray photoelectron spectroscopy) showed two nanosized phases of the metal component in all the 1% Pd/C samples studied: the oxidized surface phase of PdO and the clusters of metallic palladium with average particle size of 1.7, 1.9 and 2.2 nm, for Sibunit, Busofit and Carbopon, respectively. Differences in the values of the Pd2+/Pd0 surface ratio for the systems under investigation can be related to the different quantity and type of functional groups on the surface of carbon materials, as well as to their different specific surface area.
The polybromodiphenyl ethers content in technogenic deposits in Belarus
Authors: Kukharchyk T. I. , Chernyuk V. D. , Kazyrenka M. I. , Khomich V. S. , Kulakovich V. P. , Krylovich А. V. , Basalai E. N. , Zabrodskaya L. N.
Published: February 2025

Data on the content of one of the groups of persistent organic pollutants – polybrominated diphenyl ethers (PBDEs) in various types of technogenic substrates obtained for the first time for Belarus are discussed. The objects of the study were chemical enterprises where PBDE-based flame retardants were used, enterprises for the production of computers and household equipment, mechanical engineering and other industries potentially using materials containing PBDEs, sites for collecting and processing waste electrical and electronic equipment, waste landfills, waste water sewage sludge (WWSS) storage sites. 40 samples of technogenic substrates and 17 samples of WWSS were taken and analyzed. Chemicalanalytical determinations of PBDEs were performed using gas chromatography methods with mass spectrometric detection. Additionally, the content of bromine and antimony as indicators of the brominated flame retardants use was determined using X-ray fluorescence spectroscopy. It was shown that PBDEs were detected in 33.3 % of samples with maximum values of 5.11 mg/kg, bromine – in 40.4 % (236 mg/kg), antimony – in 15.8 % of samples (maximum value of 319 mg/kg). PBDEs were found in WWSS, technogenic substrates and silt deposits in impact zones of various local sources. The main routes of hazardous substances release into the environment and the most likely sources of brominated persistent organic pollutants (POP) are discussed. The need to develop a methodological base for environmental-geochemical studies in Belarus is shown.
Linear and volumetric parameters of the sphenoid sinus according to cone beam computed tomography
Authors: Kabak S. L. , Melnichenko Yu. M. , Savrasova N. A. , Iofereva M. P. , Shevchuk T. A.
Published: February 2025

Sphenoid sinus is one of four air-filled spaces inside cranium bones, which drain into the nasal cavity. It has high individual anatomical variability, including sexual dimorphism, ethnic and geographic variations in morphometric parameters.

The purpose of the study was to establish the dependence of the morphometric parameters of the sphenoid sinus on its extent in the dorsal and lateral directions.

Сone beam computed tomography (CBCT) data of 245 patients (98 males and 147 females, mean age 37 ± 13 years) who received dental and ENT care at a private medical center in Minsk in 2023–2024 were assessed.

The postsellar type of the sphenoid sinus was more frequent in males and females (71.4 and 66.6 %, respectively). The volume of the sinus in the present study varied between 3.4–37.5 cm3. It was larger in males. In patients under 30 years of age, the volume and width of the sphenoid sinus were significantly larger compared to patients 31–84 years old. All linear dimensions of the sinus were significantly larger in the postsellar type. The width and volume of the sinus were significantly larger as lateral expansion into the greater wings of the sphenoid occurred. In 56.7 % of patients, the sphenoid sinus was divided by the septum into right and left parts, most often asymmetric. In 11.0 % of cases, one air cavity was detected. In 32.3 %  of patients, in addition to the main septum, accessory septa were present, which in about half the cases were inserted at the wall  of carotid prominence.

Due to the high variability of the morphometric parameters of the sphenoid sinus, when considering the possibility  of an endoscopic transsphenoidal approach to the skull base, a thorough preoperative CBCT examination of the sinuses  is recommended.
Genetic diversity and molecular epidemiology of Coxsackie virus B5 in the Republic of Belarus (2003‒2023)
Authors: Paklonskaya N. V. , Amvrosіeva T. V. , Bogush Z. F. , Kaltunova Yu. B. , Belskaya I. V.
Published: February 2025

Coxsackie virus B5 is the most frequently detected enterovirus in Belarus over the past 20 years. Its dominance was accompanied by a significant genetic diversity: 12 genetic variants of the virus belonging to 2 previously identified genogroups and 5 subgenogroups (A1, A3, A4, B1, B2) were identified. Genetic variants of the virus belonging to different genogroups and subgenogroups circulated simultaneously throughout the entire observation period. Genetic variants had 3 main circulation patterns: long-term circulation within the country for 7‒15 years, long-term global circulation with periodic introductions in Belarus, short-term circulation for 1‒3 years followed by extinction. The countries of origin of the most resent common ancestor are China, France, and Belarus (for 8 of 12 studied genovariants, the probability was 89–100 %). The time interval between the divergence of genetic variants from the most recent common ancestor and its detection in the population was 3.1 ± 1.2 years. All amino acid substitutions found in different genetic variants were previously revealed in various strains of the virus circulating in other countries of the world and were described as neutral.Further enterovirus molecular surveillance will expand our knowledge about the virus concerning evolutionary patterns and general epidemic processes.
Directions for improving the balance of functioning of agroindustrial holdings
Authors: Gusakov E. , Saiganov A. , Rusakovich A. , Yermalinskaya N.
Published: February 2025

The article considers the semantic and methodological platform for analyzing the concept of balance. The structure of the subject-object configuration of integration interaction in the context of assessing balance is studied. Directions for ensuring the balance of functioning of regional agroindustrial holdings are proposed, including the coordination of interests of participants, the development of an investment strategy for the association, the creation of production units at the level of the management company, and the improvement of trade and sales activities.

The development of an investment strategy for the association involves drawing up a roadmap for the implementation of investment projects and a matrix of financing and effects of investment projects. The creation of production units, including machine-technological stations of repair shops, at the level of the holding’s management company is aimed at providing services to subsidiaries that compensate for their lacking resources. Improvement of trade and sales activities includes: unification of distribution networks of holding participants, formation of an optimal portfolio of brands.
Theoretical aspects of ensuring the sustainability of agroindustrial production in modern conditions
Authors: Kotkovets N.
Published: February 2025

The provisions in the development of theoretical and methodological foundations of state regulation of agroindustrial production in order to ensure its sustainability in terms of production, economic, social and environmen- tal components are developed. The revealed regularities of development in the context of world market trends and approaches of state regulation are presented. The mechanism of regulation of sustainable development of agroindustrial complex based on complex tools: program development, state support of agricultural producers, regulation of product market balance, stimulation, motivation and control is substantiated.
Theoretical foundations of the formation of a model of personnel management in the agroindustrial complex in the context of digitalization
Authors: Dorofeeva A.
Published: February 2025

The article provides a comparative analysis of the definitions of “personnel”, “personnel” and “labor potential”, which allowed us to develop the author’s definition of the essence of “personnel management in the agroindustrial complex”. The structural model of the system of personnel management in the agroindustrial complex in the conditions of digitalization, taking into account the transformation of professions, consolidation of the list of job responsibilities, etc. is developed. From the position of the development of theoretical foundations of management, special attention is paid to the content of the model elements (principles, factors, methods, etc.).
Inovações na educação e promoção da saúde
Authors: Sousa Maiara Gadelha de , Evangelista Brenda Pinheiro , Evangelista Breno Pinheiro , Nóbrega Lauradella Geraldinne Sousa
Published: February 2025

Resumo
ESCUTAS CLÍNICAS – UM RELATO DE PRIMEIRA EXPERIÊNCIA NO CAPS
Authors: FONSECA BRUNA MELLO DA
Published: February 2025

O presente escrito tem como objetivo compartilhar um pouco do que foi a vivência enquanto psicóloga e
psicanalista de atuação clínica no dispositivo Centro de Atenção Psicossocial (CAPS), ferramenta do SUS
para o atendimento e tratamento de transtornos em saúde mental. Após anos de exclusiva escuta clínica
psicanalítica em consultório, este trabalho representa um testemunho do que foi meu encontro com a
política pública que embasa e sustenta o CAPS na prática, dividindo angústias, reflexões e críticas do que
foi essa atuação. Para tanto, este trabalho terá como metodologia o relato de experiência, assim como irá
abordar o que é o CAPS, em que plano de política de saúde se situa e quais os atravessamentos da escuta
clínica nessas particularidades. A partir do relato de experiência também será dividido um fragmento de
caso, no qual será garantido sigilo e ética a partir da metologia psicanalítica que interpreta o caso como
ficção e, assim, serão discutidas especificidades do sofrimento que chega ao CAPS, sendo este social ao
mesmo tempo em que subjetivo.
Research on the Path to Enhancing the Internationalization Ability of Vocational Education Teachers Under the Background of Hainan Free Trade Port Construction
Authors: Li Xiaoyan , Wang Shi
Published: February 2025

This study aims to explore the improvement path of vocational education teachers' internationalization ability under the background of Hainan Free Trade Port construction, in order to meet the demand for international talent cultivation in regional economic development. Using literature research method to sort out relevant theories and practical experiences at home and abroad, collecting data on the current status of internationalization ability of vocational education teachers in Hainan through questionnaire surveys and interviews, and using case analysis method to analyze typical cases to extract successful experiences. Research has found that vocational education teachers in Hainan currently have deficiencies in international perspectives, cross-cultural communication skills, and the ability to integrate international educational resources. To this end, it is proposed to strengthen international education and training, build international exchange and cooperation platforms, and improve teacher evaluation and incentive mechanisms. Through practical case verification, these paths can help enhance teachers' internationalization ability, thereby improving the quality of vocational education talent training, providing strong talent support for the construction of Hainan Free Trade Port, and also providing reference for the internationalization development of vocational education in other regions.
A Popular Participation Model to Avoid a New Governance Crisis in Venezuela and Peru: A Study of the Oil and Mining Industries
Authors: Angelis Cristiano De
Published: February 2025

Shared governance through popular participation and social oversight represents a significant challenge and opportunity in combating corruption and enhancing public policy effectiveness. This study, which involved a survey of 35 interviews with students from Peru and Venezuela (University Mayor de San Marcos, Lima y University Carabolo, Valencia) and employed Structural Equation Modeling, proposed a theoretical model titled Popular Participation and Cultural Chage to reduce Corruption -PMRC.
Considering Venezuela's position as one of the largest oil producers in the world, the research focused on the following central question: What is the impact of Venezuelans' social participation in public policies related to gasoline supply?
Despite receiving financial aid from China and Russia to support both the public and private sectors, the Venezuelan government charges $1.36 per liter of gasoline—the highest price in Latin America—despite a production cost of only $0.035 per liter.
The study's key conclusion is that the governments of Venezuela and Peru are exploiting societal ignorance by closing educational institutions and restricting access to comprehensive knowledge, limiting citizens to only basic information.
The research model suggests that promoting knowledge-sharing within society and with other nations holds transformative potential for national cultural change, ultimately contributing to the reduction of corruption. The study emphasizes that combating corruption requires shifting from a purely legalistic approach to fostering an ethical cultural transformation, beginning with exemplary governance practices.
Translation-Based Rewriting of Orientalist Writings on Saudi History
Authors: Alkhaldi Amal Rakan
Published: February 2025

This study contends that rewriting can be used to address flaws in the source text when ideological reasons take precedence. The study examines translation as rewriting using the Lefevere notion, which entails altering texts with cultural and ideological ramifications. The author examines two published Arabic versions of Johann Ludwig Burckhardt’s Travels in Arabia 1829. A comparative descriptive approach was used to investigate the effect of the dominant ideology in a given society at a given time on the translator’s choice of strategies in the translation process. Two translations of the same text were compared: one completed by Saudi translators and the other by a non-Saudi translator. We discovered that, most of the time, the Saudi translators adapted to the ideological power structures especially when the text is concerned with ideological, regional, religious and social structural facts.
Artificial intelligence in multi-omics data integration: Advancing precision medicine, biomarker discovery and genomic-driven disease interventions
Authors: Hassan Ali
Published: February 2025

The integration of multi-omics data—encompassing genomics, transcriptomics, proteomics, and metabolomics—has revolutionized biomedical research, offering unprecedented insights into disease mechanisms and therapeutic interventions. However, the complexity and volume of multi-omics datasets present significant analytical challenges that traditional computational methods struggle to address. Artificial Intelligence (AI), particularly deep learning and neural networks, has emerged as a powerful tool to overcome these limitations by enabling advanced data integration, biomarker discovery, and personalized treatment strategies. This paper explores the role of AI-driven multi-omics data integration in enhancing disease prediction, early diagnosis, and precision medicine. By leveraging AI models such as deep neural networks (DNNs), convolutional neural networks (CNNs), and transformers, researchers can analyze complex biological interactions, identify patterns indicative of disease onset, and stratify patient populations for tailored treatment approaches. Additionally, AI-powered feature selection methods facilitate the identification of disease-specific biomarkers across multiple omics layers, paving the way for more effective targeted therapies. Moreover, AI plays a crucial role in pharmacogenomics by predicting individualized drug responses, optimizing dosage regimens, and minimizing adverse drug reactions. Machine learning algorithms, including reinforcement learning and generative models, enable real-time modeling of drug-gene interactions, leading to safer and more efficacious therapeutic interventions. Despite the transformative potential of AI in multi-omics data analysis, challenges such as data standardization, model interpretability, and ethical considerations must be addressed to ensure reliability and clinical applicability. This paper provides a comprehensive review of AI-driven multi-omics research, highlighting current advancements, challenges, and future directions in precision medicine.
Systemic financial risks in an era of geopolitical tensions, climate change, and technological disruptions: Predictive analytics, stress testing and crisis response strategies
Authors: Adriana N Dugbartey
Published: February 2025

Systemic financial risks have become increasingly complex and unpredictable due to the interplay of geopolitical tensions, climate change, and rapid technological disruptions. Financial markets and institutions face heightened uncertainty, driven by shifting global power dynamics, trade conflicts, and regulatory changes that impact economic stability. Concurrently, climate-related risks, including extreme weather events, resource depletion, and the transition to sustainable energy, pose long-term threats to financial assets, investment portfolios, and economic resilience. Technological disruptions, particularly those stemming from artificial intelligence, cybersecurity vulnerabilities, and digital financial innovations, further complicate risk management by introducing new vulnerabilities and systemic contagion pathways. In this evolving risk landscape, predictive analytics and stress testing have emerged as essential tools for identifying vulnerabilities, quantifying financial shocks, and developing proactive mitigation strategies. By leveraging machine learning models, big data analysis, and scenario-based forecasting, financial institutions can assess the potential impact of geopolitical instability, environmental shocks, and technological disruptions on financial systems. Additionally, stress testing frameworks enable regulators and policymakers to evaluate the resilience of financial institutions under extreme conditions, ensuring adequate capital buffers and liquidity measures. This research explores how predictive analytics, stress testing, and crisis response strategies can be effectively integrated to enhance financial stability in an era of escalating global uncertainties. It examines case studies of past financial crises, emerging threats, and best practices for mitigating systemic risks. By providing a comprehensive approach to financial risk management, this study contributes to the development of adaptive strategies that safeguard economic stability amid an increasingly volatile global environment.
Analysis of Sea Transport Passenger Services on Passenger Satisfaction at the Gapura Surya Nusantara Terminal Tanjung Perak Port Surabaya
Authors: Nanda Mochammad , Akhmad Ekka Pujo Ariesanto , Prawirosastro Carlos Lazaro
Published: February 2025

This research aims to analyze sea transportation passenger services on passenger satisfaction at the Gapura Surya Nusantara Terminal, Tanjung Perak Port, Surabaya. The time used by researchers to conduct research during 6 months Land Practices (PRADA) at the Gapura Nusantara Terminal which is under the auspices of PT. Pelindo. This research uses a qualitative approach with descriptive research type. The data sources used are secondary data and primary data, for data collection techniques in the form of interviews, observation and documentation. The results of this research show that the service at the Gapura Surya Nusantara Terminal is good, seen from the aspects of safety, security, reliability, comfort, such as stretchers, CCTV, security posts, disturbance information, ticket printing machines, waiting rooms, toilets and others. However, there are factors that cause the loss of consumer confidence in the services provided by the Gapura Surya Nusantara Terminal, namely the unavailability of a suggestion box or website to accommodate complaints and suggestions, the condition of the smoking area which is a little dirty due to cigarette butts being thrown away carelessly, apart from that, passengers prefer to smoke. in the front area of ​​the waiting room rather than in a designated smoking room and there is minimal availability of rubbish bins.
Application of selected Lean tools in the improvement of work safety in the use of machinery
Authors: Małysa Tomasz
Published: February 2025

The issue of safety in the use of machinery is an important issue for both manufacturers and employers. The current legislation imposes a number of obligations on manufacturers (essential requirements) and employers (minimum requirements) related to ensuring safety at every stage from design to operation. The study analyzes the possibility of applying selected Lean Manufacturing tools to improve occupational safety in the use of machinery (work equipment). The purpose of the study is to present the possibility of application of selected LM tools on operator safety, as well as to meet the requirements of legislators relating to safety related to the use of machinery. Implemented LM solutions improve communication and organization of work, and most importantly, reduce the risks associated with the operation of machinery and equipment.
The influence of lean manufacturing and green supply chain management on firm performance: the mediating role of supply chain resilience
Authors: Songkhwan Siritida , Meathawiroon Chanchai , Thunyachairat Aannicha
Published: February 2025

This study examines the relationships between lean manufacturing, green supply chain management (GSCM), supply chain resilience (SCR), and firm performance in Thai manufacturing companies. Using data from 322 employees across various industries, the research employs co-variance-based structural equation modelling to test a series of hypotheses. The findings reveal that lean manufacturing has significant positive effects on both GSCM practices and firm performance. GSCM practices demonstrate a strong positive impact on SCR. However, contrary to expectations, the study finds no significant direct relationship between GSCM practices and firm performance, nor between SCR and firm performance. The hypothesized mediating roles of GSCM practices and SCR in the relationship between lean manufacturing and firm performance are not supported. These results suggest that while lean manufacturing and GSCM practices contribute to improved operational efficiency and environmental sustainability, their translation into enhanced financial performance may be more complex than previously thought. The study contributes to existing literature by providing empirical evidence from the Thai manufacturing context and highlights the need for further research into how operational improvements in lean and green practices can be converted into tangible financial outcomes.
Analysing the Balance of Human and Physical Resources in Outpatient Departments during the COVID-19 Pandemic
Authors: Gonçalves Bruno S. F. , Lopes Erik Teixeira , Fernandes Leonor Taborda , Pereira Jorge , Lima Rui M.
Published: February 2025

The article analyses studies on the impact of the COVID-19 pandemic on outpatient services in a large hospital, aiming to provide insights for resource management amidst disruptive events. The objectives include identifying challenges and proposing solutions to optimize service delivery and address spatial constraints using discrete-event simulation. Utilizing a case study approach, the research employs simulation as a key methodology to analyse outpatient service scenarios. Scenarios are generated by combining different probabilities of patient return to check-in with various team parameterizations. The researchers analysed historical data and key performance indicators from the simulation. The study focuses on a collaborative approach with the hospital team to ensure the relevance and applicability of proposed solutions. The research identifies bottlenecks induced by social distancing measures, particularly in patient reception and check-in areas. Uneven service distribution throughout the day leads to a misallocation of resources and reduction of available physical space. Telemedicine emerges as a significant response, effectively addressing both service optimization and physicians’ workload despite spatial constraints. Additionally, the study underscores the role of simulation in crisis decision-making for hospital operations management. Practical applications emanating from the study emphasize the need for healthcare institutions to adopt adaptable strategies and leverage simulation tools for effective resource management during disruptive events. Hospital administrators can draw insights to inform resource reallocation and workflow optimization, with a focus on negotiating flexible scheduling and exploring telemedicine to enhance service delivery.
Towards a Decision-Making Framework for Successful ERP Project Implementation: A Qualitative Study
Authors: ‘yarfi Hanane L , Motaki Noureddine , Derrhi Mostafa , Lahlou Imane
Published: February 2025

Digital transformation has become a strategic imperative for businesses across industries in today’s rapidly evolving technological landscape. At the heart of this transformation lies Enterprise Resource Planning (ERP), a comprehensive software solution that integrates various aspects of a business to streamline operations, optimize resources, and enhance decision-making. The purpose of this study is to present the different fixed costs in ERP projects, develop a framework that includes the different dynamic cost elements and critical decisions during the whole ERP project lifecycle, and examine tangible benefits through various case studies from the literature. By thoroughly understanding the costs and key considerations for adoption, organizations can make informed decisions that lead to successful ERP implementations. This work was carried out through an analysis of literature reviews. The qualitative approach was chosen using focus group discussions followed by the Delphi method to conduct semi-structured interviews among eight industry experts to verify and validate the results. Based on this framework, the decision-makers can have a global picture of the different ERP project lifecycle phases, activities, and critical decisions that must be taken by the company and their options, as well as their related costs and key criteria to consider. The findings of this study will aid organizations that implement ERP systems in gaining a better understanding of the costs and key considerations and in helping managers think about the various feasible and optimal ERP implementation options.
Exploring the potential of catalytic cracking oil slurry as high aromatic rubber filling oil
Authors: Wali Suleiman A , Abubakar Abdulhalim Musa , Mohammed Abubakar , Jellah Alfitouri Ibrahim , Sobczak Anna , Elboughdiri Noureddine
Published: February 2025

The utilization of catalytic oil slurry furfural extract as a high aromatic filling oil holds immense potential for enhancing rubber performance and properties. This study focuses on the properties and composition analysis of oil slurries extracted from the Maoming Petrochemical No. 2 and No. 4 catalytic cracking units, revealing a high content of aromatic hydrocarbons up to 70%. Through systematic experimentation, it has been determined that the 2# slurry oil is optimal for butadiene rubber (BR), while the 4# slurry oil is well-suited for styrene-butadiene rubber (SBR). Furthermore, a market feasibility comparison evaluates the performance of synthetic rubber infused with high aromatic oil, providing insights into the potential market acceptance of the 2# and 4# slurry oil extractions. This comprehensive study not only highlights the technical advancements in rubber manufacturing but also emphasizes the competitive edge and economic viability offered by catalytic oil slurry furfural extract as a high aromatic filling oil.
A new field oriented control with synergetic control for an urban electric vehicle
Authors: Azizi Idris , Dahraoui Brahim , Haddi Ismail , Belouahchi Farid
Published: February 2025

This paper suggests a new field-oriented control strategy based on synergetic control for an urban electric vehicle propelled by a Permanent Magnet Synchronous Machine (PMSM). The overall study system is explained, with a synergetic approach, no linearization or simplification of the model is required. The method of controllers’ synthesis is analytical and it depends on non-linear models of the PMSM, also, to design the proposed synergetic controllers, three-manifolds of stator current and the speed of the propel PMSM are selected. A comparison study between the proposed strategy and the conventional one based on PI controllers using a dynamic model of a lightweight vehicle is established. The simulation results show the proposed control’s superiority, robustness, and effectiveness in static and dynamic performances; this has a direct impact on the vehicle’s comfort and energy consumption.
Evaluation of tractors based on sustainability criteria using multi-criteria decision-making methods
Authors: Peci Arianit , Puška Adis , Marinković Dragan , Nedeljković Miroslav
Published: February 2025

Selecting a tractor is one of the most complex investment decisions an agricultural producer faces. There are numerous types of tractors on the market, each differing in technical, economic, and ecological characteristics. The aim of this research is to demonstrate how multi-criteria analysis methods can aid in this decision-making process, using a practical example of selecting an optimal tractor for the Myzeqe area in Albania. In this study, a decision-making model was developed based on a hybrid fuzzy methodology, combining the fuzzy LOPCOW (Logarithmic Percentage Change-Driven Objective Weighting) and fuzzy MABAC (Multi-Attributive Border Approximation Area Comparison) methods. The findings show that the determination of criterion weights is less crucial, with the T15 tractor exhibiting the best overall indicators. This research primarily contributes to developing a methodology in agriculture that enhances production outcomes.
REDEFININDO O APOIO À RENDA MÍNIMA NO BRASIL EM TEMPOS DE CRISE E DE TRANSIÇÃO
Authors: Wolfgang Sarlet Ingo , Barbosa Jeferson Ferreira
Published: February 2025

O artigo busca realizar um balanço das alterações nas políticas de transferência e de apoio à renda no Brasil entre janeiro de 2021 e dezembro de 2023. No estudo foram levados em conta a estabilidade, a regulamentação do financiamento, projeções de reforma e as alterações efetivamente realizadas no recorte temporal. Além disso foram considerados dados relativos aos óbitos por Covid-19, níveis de desocupação no mercado de trabalho e o Produto Interno Bruto (PIB), além de dados indicativos sobre a cobertura e os benefícios do Programa Bolsa Família e Auxílio Brasil. 2021 fora impactado pela pandemia e igualmente antecedera as eleições presidenciais. Em 2022 os brasileiros optaram, em eleição, majoritariamente pela troca do Governo Federal. Ainda em um contexto político de polarização esse período foi fortemente marcado pela transição governamental: se 2021 marcara a substituição do Programa Bolsa Família pelo Auxílio Brasil, 2023 marcou o processo inverso, de revogação do Auxílio Brasil e de retomada do Programa Bolsa Família. Os dados sugeriram melhorias na cobertura e nos valores dos benefícios, no entanto as alterações ainda pareceram regidas por planejamentos de curto prazo. Além disso há incertezas quanto à efetiva estabilidade dos programas da assistência social, o seu contínuo aperfeiçoamento e financiamento.
CONSTITUCIONALISMO DIGITAL Y RESPONSABILIDAD CIVIL:
Authors: Ardissom de Souza Rodrigo
Published: February 2025

El artículo examina las transformaciones jurídicas derivadas del creciente poder delas plataformas digitales, las cuales actúan como agentes normativos que reconfiguran derechos fundamentales, soberanías y transforman las relaciones sociales, económicas y políticas en un ecosistema globalizado. Se explora la necesidad de desarrollar una nueva gramática jurídica que integre los principios del derecho constitucional con respuestas normativas innovadoras para enfrentar los desafíos éticos y sociales del entorno digital. Se propone articular eficazmente la interacción entre la responsabilidad civil –tanto objetiva como subjetiva– y los valores subyacentes a los derechos fundamentales, garantizando su protección frente a actores privados y las externalidades sistémicas de las plataformas. Además, se analiza cómo las herramientas jurídicas clásicas coexisten y se transforman mediante nuevos mecanismos normativos impulsados por dinámicas transnacionales, reflejando la tensión entre la soberanía estatal y la gobernanza global. Esta nueva gramática jurídica debe responder no solo a los desafíos normativos inmediatos, sino también propiciar una reconfiguración conceptual más amplia que equilibre la innovación tecnológica con la justicia social y la dignidad humana en el ecosistema digital.
The Root Work of Formation
Authors: Lizardy-Hajbi Kristina
Published: February 2025

"I never really noticed them on our weekly trips to town, except when they flowered. Their bright red-purple blooms – pillowed atop stout, greenish-gray branches – dotted the high desert landscape of southern Colorado in warmer months. I knew them most intimately in shrub form, but cholla cacti can grow up to fifteen feet in height or live comfortably on a kitchen windowsill..."
Relapse Frequency and Pattern Following Adjuvant Radiotherapy for Intermediate and High-Intermediate Risk Endometrial Cancer Based on Retrospective ESGO-ESTRO-ESP Risk Classification
Authors: Graham Kathryn , Hannington Laura , Duncanson Claire , Wilkinson Andrew , Cartwright Douglas , Harrand Rosie , Kerr Ashleigh , Reed Nick , Sadozye Azmat
Published: February 2025

Background: The management of early-stage endometrial cancer (EC) consists of surgery followed by tailored adjuvant therapy, largely based on the risk of loco-regional recurrence. We evaluated the frequency and site of first relapse in patients who received vaginal brachytherapy (VBT) or pelvic external beam radiotherapy (EBRT) for early-stage EC. These data were stratified retrospectively according to the European Society of Gynaecological Oncology–European Society of Radiotherapy and Oncology–European Society of Pathology (ESGO-ESTRO-ESP, 2020) intermediate risk endometrial cancer (IR-EC) and high-intermediate risk endometrial cancer (HIR-EC) classifications. Methods: The central radiotherapy prescribing system within the West of Scotland Cancer Network was analyzed to identify International Federation of Gynaecology & Obstetrics (FIGO) Stage I–II EC patients who commenced VBT, at a dose of 2100 cGy for 3 fractions, and/or EBRT, at 4500 cGy for 25 fractions, between 1st January 2017 and 31st December 2019. Clinical follow-up was conducted until death or for a maximum of five years (data lock 31st December 2022). Imaging was performed if recurrence was suspected. Statistical analysis was implemented using R statistical software (v4.4.1). Results: In total, 282 patients were identified. The median age was 69 years (range: 37–92 years), and the median follow-up was 33 months (range: 0–68 months). Stage distribution: ⅠA (25.2%), ⅠB (57.4%), and Ⅱ (17.4%). The pathology subtype was predominantly endometrioid (93.6%), but 6.4% of patients had non-endometrioid histology with no myometrial invasion. IR-EC patients comprised 51.1% of the series; all received VBT and no adjuvant chemotherapy. The HIR-EC cohort comprised 48.9% of the series; just over half received EBRT, and adjuvant chemotherapy was delivered to 15.9%. By the end of the study, 37 (13.1%) patients had relapsed, and 41 (14.5%) had died, 22/41 (53.7%) of which were attributable to EC. Recurrences were documented in 11.1% of the IR-EC patients and 15.2% of the HIR-EC patients. Vaginal, pelvic, and distant relapses per risk group and treatment were: 2.1%, 7.6%, and 6.9% in IR-EC (VBT-treated), respectively; 3.1%, 16.9%, and 6.2% in the HIR-EC (VBT-treated), respectively; 0%, 6.9%, and 9.6% in the HIR-EC (EBRT-treated), respectively. None reached statistical significance (p = 0.34, Fisher’s exact test). Salvage therapy for locoregional recurrence was performed in 3.5% (10/282) of patients, and virtually all pelvic relapses were symptomatic. Conclusions: Vaginal relapse rates were very low (1.8%). However, pelvic recurrences occurred in 16.9% of the HIR-EC (VBT-treated) patients, suggesting that external beam radiotherapy should be considered to optimize loco-regional control in this group.
Do Interventions on the Uterine Wall Increase the Risk of Developing Abdominal Wall Endometrioma?
Authors: Sakoglu Nevin , Ayvaz Seymin
Published: February 2025

Background: Abdominal wall endometriosis, which can affect the rectus abdominis muscle, has been documented in association with cesarean section scars or along pathways formed by abdominopelvic surgeries. Our study aimed to assess the risk of developing abdominal wall endometriomas following surgical interventions (cesarean section, myomectomy) on the uterine wall. Methods: Between 2011 and 2021, a total of 19,574 patients underwent cesarean section delivery through a Pfannenstiel incision. The average age of patients was 36 (20–58) years. On average, 1.5 to 2.0 years after cesarean section, 204 patients developed abdominal wall endometrioma (Group I). The control group (Group II) comprised 204 patients who had undergone cesarean section by the same method but did not develop scar endometriosis. During the same period, 200 patients underwent myomectomy with a similar incision for intramural and submucosal myomas (Group III). Postoperatively, these patients were also monitored for the development of endometrioma. One of the patients who underwent myomectomy also had surgery for an ectopic pregnancy at the same time. The data analysis included descriptive statistical methods, such as calculating the mean ± standard deviation, median (min–max), and frequencies (n (%)). The Shapiro-Wilk normality test, Kruskal-Wallis test, Dunn’s multiple comparison test, Chi-Square test, and Fisher-Freeman-Halton exact test were applied. The results were evaluated for statistical significance at a level of p < 0.05. Results: Abdominal wall endometriomas developed in 204 of 19,574 patients who delivered by cesarean section (1.04%). Endometrioma development was significantly higher in Group I, where estrogen levels were elevated (p < 0.001). The most common complaints among the patients were swelling and cyclical pain in the abdominal wall. 9 of the 204 patients who had previously developed abdominal wall endometriomas experienced recurrence (4.41%). An abdominal wall endometrioma developed in the patient who underwent myomectomy and surgery for ectopic pregnancy simultaneously (0.5%). Conclusions: Endometrioma is a multifactorial condition. High estrogen levels, surgical techniques, and an increased imbalance between estrogen and progesterone levels can trigger inflammation and lead to the development of endometriomas. We suggest that further detailed studies are needed to better understand these mechanisms.
Association of Circulating, Inflammatory Response Exosomal Long RNAs with Ischemic Stroke
Authors: He Guo-dong , Sun Shuo , Huang Yu-qing
Published: February 2025

Background: The expression profiles and function of exosomal long RNAs (exoLRs) in ischemic stroke remain unknown. This study aimed to investigate the pathophysiologic responses reflected by exoLRs. Methods: The expression profile of exosomal messenger RNA, long non-coding RNA and circular RNA in 9 patients with ischemic stroke and 12 healthy individuals were analyzed by sequencing. We assessed the immune cell landscape to reveal the pathophysiologic responses reflected by exoLRs and performed biological process and pathway enrichment analyses. Competing endogenous RNA networks were constructed to explore the molecular functions of exoLRs. Results: A total of 321 up- and 187 down-regulated messenger RNAs, 31 up- and 9 down-regulated long non-coding RNAs, and 67 up- and 48 down-regulated circular RNAs were identified. The immune cell landscape analysis identified that the proportions of exhausted and gamma delta T cells were statistically higher in patients with ischemic stroke. Bioinformatics analyses, including enrichment and competing endogenous RNA network analyses, also indicated that exoLRs were associated with T- cell-mediated inflammatory responses. Conclusions: The expression patterns of exoLRs highlighted the association between ischemic stroke and inflammatory responses mediated by T cells.
Hypoxia-Induced VGF Promotes Cell Migration and Invasion in Prostate Cancer via the PI3K/Akt Axis
Authors: Wang Leilei , Zhang Ting , Qian Yanning , Wu Yingying , Li Ting , Zheng Yongbo , Luo Chunli , Wu Xiaohou , Chen Tingmei , Ou Liping
Published: February 2025

Background: Metastasis is a major cause of prostate cancer (PCa)-related deaths in men. Recent studies have indicated that VGF nerve growth factor inducible (VGF) affects tumor invasion and metastasis. The present study investigated whether VGF is abnormally expressed in PCa and affects PCa progression and investigated the specific regulatory mechanisms by which VGF affects PCa invasion and metastasis. Methods: The sh- hypoxia-inducible factor1 alpha (HIF-1α) plasmid was transfected into human cell lines 22Rv1 and C4-2 to create cell lines with stable low expression and overexpression of VGF. Quantitative PCR (qPCR) was performed to detect VGF mRNA. Western blot was performed to detect invasive migration-related proteins. Akt activator SC79 (4 μg/mL) was added. After adding docetaxel (4 nM) to cells transfected with sh-NC and sh-VGF, the capacity of the cells to migrate invasively was assessed using the Transwell and scratch assays. Nude mice were injected with cells stably transfected with sh-NC or sh-VGF and the metastasis of the cancer cells was detected by live imaging and HE staining after the injection of docetaxel (10 mg/kg). Results: Abnormal levels of VGF in PCa tissue and plasma samples were detected, and VGF knockdown suppressed PCa metastasis. VGF was also shown to affect the invasion and metastasis of PCa cells via PI3K/Akt signaling. VGF knockdown limited PCa metastasis and the inhibitory impact was higher when paired with docetaxel (p < 0.001). After hypoxia induction, both the mRNA and protein levels of VGF and HIF-1α increased, which is associated with a poor prognosis for PCa. Conclusion: By stimulating the PI3K/Akt pathway, VGF encourages the invasive metastasis of PCa. As a result, targeting VGF may be a potential treatment approach for metastatic PCa therapy.
Stellate Ganglionectomy Attenuates Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction
Authors: Yan Hui , Li Xiujun , Liu Beilei , Wu Bin , Chen Changgui , He Liqun , Wu Gang
Published: February 2025

Background: Enhanced cardiac sympathetic activity contributes to chronic heart failure (CHF). Interventions targeting the stellate ganglion (SG) can reduce this activity, potentially slowing the progression of cardiovascular diseases. This study examined the effects and mechanisms of stellate ganglionectomy on myocardial hypertrophy and cardiac dysfunction caused by pressure overload. Methods: A rat model of pressure overload was created using abdominal aortic constriction. Four groups were studied: the sham surgery, abdominal aortic coarctation (AB), aortic constriction plus left stellate ganglionectomy (LSG), and aortic constriction plus right stellate ganglionectomy (RSG) groups. Cardiac function was assessed via echocardiography, and myocardial hypertrophy and fibrosis were evaluated using hematoxylin-eosin staining (H&E) and Masson staining. Serum atrial natriuretic peptides (ANP) and norepinephrine (NE) levels were measured using enzyme linked immunosorbent assay (ELISA), and the levels of the molecular markers tyrosine hydroxylase (TH) and growth-associated protein-43 (GAP43) were analyzed using Western blotting and PCR. Calcium calmodulin dependent protein kinase II (CaMKII) and phosphorylated Ryanodine Receptor 2 (p-RyR2) expression were also investigated. Results: Stellate ganglionectomy significantly reduced myocardial hypertrophy and improved cardiac function, as indicated by decreased left ventricular posterior wall thickness (LVPWD) (p < 0.01), left ventricular end-diastolic diameter (LVEDD) and volume (p < 0.001), left ventricular end-diastolic volume (LVEDV) (p < 0.001), increased left ventricular ejection fraction (LVEF) (p < 0.001) and left ventricular fractional shortening (LVFS) (p < 0.001). Histological analysis confirmed reduced myocardial dilation. Molecular analysis revealed decreased CaMKII/RyR2 signaling (p < 0.001) and lower NE levels (p < 0.01), suggesting reduced neurohormonal stress. Conclusions: Stellate ganglionectomy alleviates hypertrophy and cardiac dysfunction caused by pressure overload, likely through inhibition of the CaMKII/RyR2 pathway, underscoring its potential as a therapeutic approach.