bluuebunny/crossref_metadata_2025 huggingface dataset:
Webinar Tentang Communication Skills and Career Guidance Graduation di SMK Negeri 1 ALIAN Kebumen
Authors: Rizana Dani , Kristanti Ika Neni
Published: August 2021

Vocational or vocational education is an education that is different from general education. Vocational education is directed at forming graduates who have professional insight, which is something that is embedded in a person that influences his behavior, namely caring for quality (not just so), working quickly, precisely, and efficiently without or with the supervision of others, respecting time, and maintain reputation. The purpose of implementing Career Guidance in Schools is so that students can: (increase their knowledge of themselves (self-concept); increase their knowledge of the world of work; develop their attitudes and values in dealing with job choices in preparation for entering them; improve thinking skills so that they can make decisions. about positions that suit him and are available in the world of work, and master basic skills that are important in work, especially the ability to communicate, cooperate and take initiative. This service activity is carried out for 1 day using several methods, including lectures and questions and answers. This community service activity is to provide communication skills to participants as a provision for preparation for graduation so that participants develop their attitudes and values in facing employment choices or the choice of continuing to a higher level of education. The impact of this service activity provides participants with knowledge and skills about communication skills and career guidance so that participants are better prepared to choose work or continue to a higher level after graduating from school.
CONFIANÇA NAS INSTITUIÇÕES E APOIO À DEMOCRACIA BRASILEIRA ENTRE 1995 E 2018
Authors: Mello Souza Bruno , Alves de Jesus Raimundo Filipe , Ferreira Silva Warley
Published: August 2021

As instituições democráticas brasileiras sofrem com altos níveis de desconfiança, acarretados por indiferença política ou ineficiência institucional diante de demandas sociais, corrupção, fraude ou desrespeito de direitos de cidadania. Todos esses fatores influenciam diretamente o funcionamento e a qualidade da atual democracia brasileira. Levando isso em consideração, este artigo tem como objetivo verificar longitudinalmente a evolução da confiança nas instituições brasileiras e verificar o apoio à democracia entre 1995 e 2018.
Holocausto brasileiro: da violação de direitos à construção de uma sociedade sem manicômios
Authors: Gomes Coelho Gilson , Ferreira de Sousa Rodrigues Ilana Helen , Conceição Silva Karina Murielly
Published: August 2021

O presente trabalho trata-se de uma pesquisa descritiva com abordagem qualitativa e objetivou tratar, mesmo que de forma breve, sobre as violações de direitos ocorridas no Hospital Colônia, manicômio localizado na cidade de Barbacena - MG, conhecido como Holocausto Brasileiro, em função dos horrores cometidos contra aqueles denominados "loucos" ou "desviantes" da norma social, tomando como bibliografia para este estudo o documentário Holocausto Brasileiro (2016) e o livro de mesmo título da autora Daniela Arbex (2013). Nesse sentido, contextualiza-se a loucura e seus desdobramentos no Brasil para a compreensão do modo com qual essa loucura era tratada e as pessoas que apresentavam alguma psicopatologia eram vistas pela sociedade. Aborda-se o processo da Luta Antimanicomial e da Reforma Psiquiátrica, que visavam uma outra forma de atuação para com as pessoas com transtornos mentais, evidenciando que apesar dos avanços e transformações ocorridos, ainda existem desafios a serem superados. Por fim, apresenta-se o código de ética e o papel do psicólogo nesse contexto, com o propósito de fornecer um panorama sobre a importância da atuação de profissionais comprometidos ética e politicamente em favor da saúde mental e dos direitos dos sujeitos.
RELATIONSHIP OF HYPOGONADISM & ERECTILE DYSFUNCTION IN PATIENTS OF TYPE II DIABETES PATIENTS IN NORTH BIHAR A CROSS SECTIONAL STUDY
Authors: Chandra Jha Umesh , Tiwari Amit Kumar
Published: August 2021

INTRODUCTION: Diabetes is a metabolic syndrome characterized by hyperglycemia resulting from defects in insulin secretion, insulin action,
or both. The persistent state of hyperglycemia has serious effects on virtually every body system, including but not limited to neuropathy,
vasculopathy, as well as endocrinological changes, which all together lead to grave effects on the patient's quality of life. Androgen deciency has
recently been identied as the dark side of type-II diabetes in male patients, leading to hypogonadism and erectile dysfunction.
OBJECTIVES: Indentify any correlation between type II diabetes mellitus and the hypogonadism and erectile dysfunction. Search for any
correlation between hypogonadism and glycemic parameters of the patients.
MATERIALS AND METHODS:
STUDYSETTING: DEPARTMENTOF MEDICINE, DARBHANGAMEDICALCOLLEGE & HOSPITAL, LAHERIASARAI, India.
Total estimated sample size: 200 (group I-100 samples, group 2-100samples)
RESULTAND ANALYSIS: In Case Group, 53(53.0%) patients were smoker. In Control Group, 30(30.0%) patients were smoker. Association of
SMOKING vs group was statistically signicant (p=0.0009). In Case Group, 85(85.0%) patients had NON SPECIFIC SYMPTOMS. In Control
Group, 12(12.0%) patients had NON SPECIFIC SYMPTOMS. Association of NON SPECIFIC SYMPTOMS vs group was statistically signicant
(p<0.0001).
SUMMARYAND CONCLUSION:It was showed that difference of mean LH (mIU/ml) with both group was not statistically signicant. In Case
Group, the mean total testosterone (ng/dl) (mean± s.d.) of patients was 192.2021± 118.6405 and In Control Group, the mean total testosterone
(ng/dl) (mean± s.d.) of patients was 149.7200± 26.4812. Total testosterone was high in cases compared to control and that was statistically
signicant.
PERINATAL OUTCOME OF MECONIUM STAINED LIQUOR IN TERM, PRE-TERM & POST-TERM PREGNANCY
Authors: Kumari Anjani , Jabin Hena , Jha Renu
Published: August 2021

Introduction: Meconium aspiration is commonly dened as the presence of meconium below the vocal cords. Meconium aspiration is more common if the meconium is thick rather than thin. This may be a reection of the fact that oligohydramnios (and therefore thick undiluted meconium) is more likely to lead to fetal hypoxia due to cord compression and consequently increased fetal breathing. Aim: To determine the incidence of cases having meconium stained liquor during labour. To classify the total no. of cases with meconium stained liquor in labour on the basis of gestational duration (term, pre-term and post-term), as well as mode of delivery. To correlate the perinatal outcome with incidence of meconium staining of liquor during labour. To reduce perinatal mortality & morbidity. Materials And Methods: The present study was conducted at Darbhanga Medical College and Hospital, during the period of December 2018 to November 2020. During the study period, total number of deliveries was 3500, the number of cases selected for the study were 1680. Intrapartum meconium stained liquor was present in 165 cases (11.01%). Cases with clear liquor in the intrapartum period 1495 cases (88.99%) were taken as controls. Result: No signicant correlation was noted between maternal age and meconium staining of liquor. The incidence of staining was higher i.e. 17.1% in higher gestational age of foetus i.e. 41-42 weeks. Our study also yielded results of rising incidence of low –birth weight babies(less than 2.5kg) in meconium stained liquor cases. Instrumental vaginal deliveries and caesarean sections were found to be more prevalent in these cases. Mean Apgar Scores were signicantly lower in cases complicated with thick stained liquor than in thin stained liquor or clear liquor. Conclusion: It can be said that our study has revealed some results that further establishes some well-known facts about meconium stained liquor. Meconium stained liquor is a very common complication during labour and its incidence is 11.01% as per this study. Incidence of instrumental vaginal delivery and caesarean section is signicantly increased when liquor is meconium stained during labour.
EFFICACY OF INTRAPERITONEAL INSTILLATION OF 0.2% ROPIVACAINE FOR POSTOPERATIVE PAIN RELIEF AFTER LAPAROSCOPIC CHOLECYSTECTOMY
Authors: Gangopadhyay Debottam , Agarwal Rahul
Published: August 2021

INTRODUCTION: Postoperative pain management is one of most important components of adequate postoperative patient care. Poorly treated
pain contributes to patient suffering and may prevent rapid recovery and rehabilitation. Laparoscopic operative procedures have revolutionized
surgery with many advantages : a smaller and more cosmetic incision, reduced blood loss, reduced postoperative hospital stay and pain, which cut
1
down hospital costs .
AIMS AND OBJECTIVES:Aim of the study is to evaluate the efcacy of intraperitoneal instillation of ropivacaine for postoperative pain relief
after laparoscopic cholecystectomy surgeries in terms of : Duration of analgesia, 24 hour postoperative analgesic requirement, Postoperative pain
assessment, Postoperative hemodynamic changes like pulse rate, blood pressure and Complications (if any).
MATERIALS AND METHODS: Study area -Command Hospital (Eastern Command), Alipore, Kolkata (operation theatre and ward).
Study population - Patients posted for Elective Laparoscopic Cholecystectomy.
Study period -Jan 2017 to June 2018
Study Time– From rst intraoperative intraperitoneal instillation of study drug to next 24 postoperative hours.
Sample Size - 80 (40 in each group)
RESULTS AND ANALYSIS: In our study, intraperitoneal instillation of Ropivacaine at the end of surgery provided analgesia for 5.54 ± 4.61 hrs.
When compared with the saline group, it was about 2.22 ± 2.93 hrs, which was found to be statistically signicant (-0.004). In this study, Injection
Tramadol was used for rescue analgesia for postoperative pain relief.
SUMMARYAND CONCLUSION: This study has a few limitations. First, eighty study population may be underpowered for the study. Second,
the surgeon performing the surgeries is not the same in every case which may alter the postoperative consequences. From this study it may be
concluded that intraperitoneal instillation of Ropivacaine is effective for postoperative pain relief after laparoscopic cholecystectomy. From this
study we also conclude that, intraperitoneal instillation of Ropivacaine is useful for postoperative pain relief for patients undergoing laparoscopic
cholecystectomy in terms of duration of analgesia, rescue analgesic requirement and pain perception.
TORASEMIDE FOR THE TREATMENT OF HEART FAILURE
Authors: Dhanraj Ramteke Harshawardhan , Rajesh Menon Roshan
Published: August 2021

Diuretics play a major role in the rst line treatment for the Congestive Heart Failure (CHF). These diuretics are currently and majorly used for
symptomatic relief. Torasemide, a loop diuretic, is a newly developed loop diuretic, which has a longer half-life, longer duration for action, and
higher bioavailability as compared to the other loop diuretics like furosemide. Torasemide, also works more effectively for the anti-aldosterone
effect and vasorelaxation effect. Several studies have also suggested that torasemide has superior pharmacokinetics and pharmacological activities
than that of furosemide. Results of several studies state that torasemide helps in improving the left ventricular function, reduces the mortality, as
well as the frequency and duration of heart failure. Torasemide also improves the quality of life, tolerance and NYHA functional class in patients
suffering from CHF. Based on these results, torasemide appears to be a promising loop diuretic for the rst line treatment and for better
management of the patients with CHF. In this review, we provide a panorama of existing knowledge on the properties of torasemide, aimed at using
it as a rst line of treatment for the patients in Congestive Heart Failure (CHF).
SARS-COV-2 SEROPREVALENCE AMONG EMERGENCY PROVIDERS AND THE IMPORTANCE OF PERSONAL PROTECTIVE EQUIPMENT.
Authors: Pham Tuong , Doctor Michael , Reyes Ryliezl Abby , Runco Caroline , Hazan Alberto , Olivieri Patrick
Published: August 2021

Background: Healthcare workers (HCWs) have elevated exposure risks to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
However, there is limited published information regarding the transmission rate and the seroconversion among HCWs. The goals of this study are
to determine the seroprevalence among emergency providers and the correlation between working hours and utilization of personal protective
equipment with the likelihood of seroconversion.
Methods: This prospective study evaluated Emergency Department physicians and advanced practice providers, who had been tested for SARSCoV-2 IgG serology, at 10 different hospitals in the location area. An anonymous survey was sent to the Emergency Department providers via email
inquiring about the following: results of serology and/or nasopharyngeal testing, the testing site used, the presence or absence of COVID-19
symptoms, utilization of personal protective equipment (PPEs), exposure to potential COVID-19 patients, and average clinical hours since March.
Results: 43 participants responded to the survey. 3 had positive SARS-CoV-2 antibody or viral tests indicating exposures to COVID-19 despite
utilization of various types of PPE. There was a surprisingly high number of HCWs treating known/suspected COVID-19 patients without proper
PPE (18.6%). 21 (48.8%) HCWs routinely wore an N-95 mask, 11 (25.6%) used a powered air-purifying respirator (PAPR), 6 (14%) wore surgical
masks, and 5 (11.6%) used elastomeric face respirators. None of the COVID-19 positive HCWs used a PAPR while treating known or suspected
COVID-19 patients.
Conclusion: Our knowledge regarding the complications related to SARS-CoV-2 infection post-acute phase remains limited. Our data suggest
PAPR use may be protective compared to other PPE modalities. There can be unanticipated long-term morbidities that result from an infection with
SARS-CoV-2. Therefore, frontline HCWs, who have an inherently elevated exposure to this virus, must use PPE and maintain vigilance while
treating patients, regardless of the presence of COVID-19 symptoms.
A STUDY ON CLASSIFICATION OF INHIBITORS OF FATTY ACID TRANSPORT PROTEIN-2 IN CELL
Authors: Singh Anand Shanker , Radhika G . , Kumar R . Praveen , Jana Debarshi
Published: August 2021

Inhibition of uptake of fatty acids in non-adipose tissues seems an attractive mechanism for treatment of lipotoxicity, dyslipidemia and other
elements related to metabolic syndrome and obesity. Fatty acid transport proteins (FATPs) are bifunctional proteins involved in the uptake and
activation of fatty acids by esterication with coenzyme A. To date, only inhibitors specic to FATP1 and FATP4 have been identied. Here we
characterize a FATP2-specic fatty acid uptake inhibitor, CB5. Identied in a high throughput screening in yeast transformed with humanFATP2,
CB5 is effective in inhibiting the uptake of fatty acid at low micro-molar ranges in cell lines that are models for intestines, liver, muscle, pancreas
and adipose tissue with varying potencies.
Inhibition was also specic for long and very-long chain fatty acids and not for medium chain fatty acids, which are transported by diffusion.
Finally, CB5 was effective in protecting the cell lines that are models for liver and pancreas and primary liver cells from lipotoxic effects of
saturated fatty acid, palmitic acid. High throughput screening also identied clozapine and chlorpromazine, atypical antipsychotics drugs, as
inhibitors of FATP2-mediated fatty acid uptake in yeast system. However, atypical antipsychotics were ineffective in inhibiting the uptake of FAanalog C1-BODIPY-C12 in HepG2 cells. They were also ineffective in protecting HepG2 cells from the lipotoxic effects generated by saturated
fatty acid compared to CB5 that exhibited protection to the cells, demonstrating that they are not effective inhibitors of fatty acid transport
compared with CB5.
CRITICALANALYSIS ON THE POEMS OF JAYANTA MAHAPATRA WITH REFERENCE TO THE ECO-CRITICAL PRAXIS: ECO-POETICS AND CULTURAL ECOLOGY.
Authors: G Ranjit , K Rajkumar
Published: August 2021

Jayanta Mahapatra is one of the doyens of Indian English literature. Being an Indo- Anglican writer, he came to the literary arena in his later half of
his life. He was then conferred with Sahitya Akademy award for his seminal work Relationship in 1981. This gave him the title of a modern Indian
writer among the international literary circle. Most of his works are bound to the culture of Orissa and his works are rich in images picked from
Bhubaneswar, Konarka, Puri and Chilka lake. He is a patron of Indian civilization and an ardent ghter against environmental concerns, social
issues and political inequalities. Reading Mahapatra’s poems under Ecocritical praxis is an interesting realm of inquest where he has penned his
genuine concerns and cultural tracks through his poems. Eco-poetic aspects are abundant in his poems that Mahapatra reconnects the human
activity with nature and also resist the current human intervention in this exploitive capitalistic world. Cultural ecology has a deep connection in his
poems that his characters are the testimonies of the reconnection between man and nature. Irrespective of his age, he is still an ardent writer who has
a vision for optimistic posterity.
LARGE PLEXIFORM NEUROFIBROMA OF THE SACRO-GLUTEAL REGION – A RARE CASE REPORT
Authors: Venkata Mahipathy Surya Rao Rao , Durairaj Alagar Raja , Sundaramurthy Narayanamurthy , Jayachandiran Anand Prasath , Rajendran Suresh
Published: August 2021

Plexiform neurobroma is a rare benign nerve sheath tumor that develops in the perineurium and is often considered pathognomonic of
neurobromatosis type 1 (NF1 or von Recklinghausen disease). They occur most frequently in the craniomaxillofacial region, rarely on back and
extremities. These lesions are highly vascular and there is 15-20% potential for malignant transformation. Here, we present a 26-year-old female
with neurobromatosis all over her body, but with a large plexiform neurobroma in the sacral region which was causing difculty in sitting and
lying supine as well as disgurement of the gluteal region. Surgical excision with primary closure of the swelling was done. Histopathology
ndings were consistent with neurobromatosis.
CALCULATION AND ANALYSIS OF EFFECTIVE ATOMIC NUMBER USING AUTO ZEFFECTIVE METHOD FOR BORO-SILICATE GLASS SERIES GLASS [Li O – B O – SiO 2 2 3 2 – XO] WITH THIRD (5D) D-BLOCK (HF–HG) TRANSITION METALS ELEMENTS (X)
Authors: Markanda Sangeet
Published: August 2021

The impact of the doping of the transition metals with Lithium Oxide provides signicant data in Boro-silicate materials. Hence their
comprehensive study with Lithium in Boro-silicate glass studied in the present paper. Z-effective shows non consistence in study respective to
energy and even more anomalous with respective to the atomic number at lowest energy levels (0.01 MeV). Variations in Z-effective are high with
increase in energy among all 5d metals used in given series of glass. For 1 to 100 MeV a small variation observed in data as it ranges 9 to 21 (Zeffective). Even variation is symmetrical within the 5d transition metals except for Hf (72) and Ta (73)
A COMPARATIVE STUDY OF ABG PATTERN IN PATIENTS OF COPD WITH OR WITHOUT COR PULMONALE
Authors: Alam Md Shoeb , Ranjan Rahul , Jha V N
Published: August 2021

INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is a major public health problem. COR PULMONALE describes the
enlargement and failure of the right ventricle of the heart as a response to increased vascular resistance or increased pulmonary artery pressure.
Hypoxic pulmonary vasoconstriction, hypercapnia, respiratory acidosis and pulmonary vascular remodeling in COPD can cause an increase in
right ventricular (RV) after load, which in turn, results in RVfailure leading to COR PULMONALE
AIM:The purpose of the study is to compare the ABG pattern in patients of COPD with or without COR PULMONALE.
MATERIALS AND METHODS: This prospective observational study was conducted in the Department of Medicine of DMCH, Laheriasarai,
Bihar. The study was conducted with duration of 2 years. Atotal of 100 patients admitted as a case of COPD with or without COR PULMONALE.
The patients were put into two subgroups, COPD with and without COR PULMONALE.
RESULT: The mean duration was 10.17 years and 9.20 years respectively in patients with and without COR PULMONALE. There was no
statistically signicant difference regarding mean duration of disease (p value =0.304). Mean CAT score was 16.59 ± 6.26 and mean mMRC was
3.19± 0.45 in COPD patients with COR PULMONALE group. Mean CAT score was 14.06 ± 4.46 and mean mMRC was 3.10 ± 0.44 in COPD
patients without COR PULMONALE group. We found no signicant difference among these variables between groups. Although COR
PULMONALE patients had higher CATscore and mMRC score, the difference was not signicant (p value = >0.05).
CONCLUSION:ABG ANALYSIS should be recommended for all patients of COPD with or without COR PULMONALE to assess the degree of
hypoxemia, hypercapnea, respiratory acidosis and also, we can identify individuals who need more close monitoring and intensive treatment.
Human Resource Outsourcing and Skill Variety of Outsourced and Core Staff: Evidence from the Nigerian Banking Industry
Authors: Nwakanma Chinegbomkpa Hope , Onyeonoru Ifeanyi P.
Published: August 2021

In Nigerian banking industry, Human Resource outsourcing has grown beyond the externalisation of auxiliary activities to include core activities. The consequences of this practice on employee skill variety are rarely discussed in the industry. This study therefore, investigated the skill variety of outsourced and core staff in Nigerian banking industry with evidence from Bank X, Southeastern region. Survey research design was adopted. Bank X was purposively selected due to its reputation for employing outsourced staff in its core banking operations while its branches in Abia, Imo and Enugu States were randomly selected. All 352 workers in the three States comprising 218 outsourced and 134 core staff were enumerated. Mixed methods were used to collect data while descriptive statistics and Chi square at p<0.05 alpha level of significance were used to analyse data. Outsourced staff had less variety in their tasks compared to the core staff. They had less opportunities to acquire additional skills and were required to utilise fewer skills in the course of their work, leading to low skill variety. Their employment status by implication deprived them of human capital investment either privately or corporately. Mode of employment was significantly associated with skill variety.
Farmers-Herders Conflicts and Development in Nigeria
Authors: Akanle Olayinka
Published: August 2021

The conflict between farmers and herders have constituted serious concerns and impediments to development in Nigeria. Development entails food security, of which dairy needs are integral. The global campaign for good agricultural practices (GAP) essentially focuses on the preservation of humans, animals and the general ecosystem, as the world continues to confront the depletion of the ozone layers. In Nigeria, the development concerns of farmers-herders’ conflicts are not only pertinent but also daunting as the protracted conflicts increase the burden of food insecurity, human insecurity, ethic/tribal tensions and underdevelopment outcomes. While the challenges posed by the farmers-herders’ conflicts are serious, existentially threatening and hydra-headed, their impacts on development of the country are massive and require urgent attention research and policy terms. This is because development can only be sustainable in an atmosphere of peace and tranquillity. But in situations where conflicts and insecurity are near intractable, development may be mere desideratum. It is against this background that Maslow’s Hierarchy of Needs was used to examine the context, burden and tractability of farmers-herders’ conflicts in Nigeria with a view to unpacking the interface of (in)security and development relative to food security in Nigeria.
An Ultra-Cheap Light Field Microscope for Volumetric Cellular Imaging
Authors: Zheng Zhiyu , Wu Yinzhe , Gurung Amul , Liu Xinyue , Li Lai Yan , Zhu Haobo , Howe Carmel , Quicke Peter , Schultz Simon
Published: August 2021

We present a novel light field microscope (LFM) hardware
design which benefits from scaled productions of cameras
and other optical components. Our design has dramatically
lower cost (< GBP 2000) yet only slightly compromised
performance. This novel LFM design enables transient volumetric imaging at a cellular resolution at a much lower cost.
Editorial
Authors: Martins Sandra Eli Sartoreto de Oliveira
Published: August 2021

O segundo volume da Revista Diálogos e Perspectivas em Educação Especial (RDPEE) de 2020 reúne uma série de relatos de pesquisas, de experiência e de revisão bibliográfica que retratam a divulgação de estudos na área de Educação Especial e Educação Inclusiva. Esse número buscou reunir reflexões sobre temas diversos no cenário da produção de conhecimento em Educação Especial, com indicação de respostas educacionais inclusivas para estudantes com deficiência e para a atuação de professores e outros profissionais que atuam no contexto educacional.
PENGARUH VARIASI KONSENTRASI HPMC DAN GLISERIN TERHADAP SIFAT FISIK GEL HAND SANITIZER EKSTRAK ETANOL DAUN PALA (Myristica fragrans Houtt.)
Authors: Shintia Citra , Endah Srie Rezeki Nur , Nofriyaldi Ali
Published: August 2021

Daun pala (Myristica fragrans Houtt.) mengandung senyawa flavonoid, saponin dan tanin yang berpotensi sebagai antibakteri, sehingga dapat dimanfaatkan kedalam bentuk sediaan gel hand sanitizer. Persyaratan yang harus dipenuhi untuk sediaan gel salah satunya adalah sifat fisiknya. Gelling agent dan humektan merupakan faktor yang dapat mempengaruhi sifat fisik sediaan gel. Penelitian ini bertujuan untuk mengetahui pengaruh variasi konsentrasi HPMC (Hidroxy Propyl Methyl Cellulose) dan gliserin terhadap sifat fisik sediaan gel hand sanitizer ekstrak etanol daun pala. Gel hand sanitizer ini dibuat formulasi dengan variasi HPMC dan gliserin, yaitu formula 1 (HPMC 1% : gliserin 5%), formula 2 (HPMC 1,5% : gliserin 7,5%), formula 3 (HPMC 2%, gliserin 10%). Evaluasi yang dilakukan terhadap sediaan meliputi, uji homogenitas, uji organoleptik, uji pH, uji daya sebar, uji daya lekat. Berdasarkan hasil analisis menggunakan One Way Anova dengan program SPSS for Windows, menunjukan bahwa HPMC dan gliserin mempengaruhi parameter daya sebar dan daya lekat sediaan gel hand sanitizer ekstrak etanol daun pala (Myristica fragrans Houtt.).
Network Meta-Analysis of Once Weekly Selinexor-Bortezomib-Dexamethasone in Previously Treated Multiple Myeloma
Authors: Dolph Michael , Tremblay Gabriel , Gilligan Adrienne M , Leong Hoyee
Published: August 2021

Background: Despite the availability of new treatments, multiple myeloma (MM) is an incurable cancer with nearly all patients relapsing and undergoing multiple lines of treatment. Performing head-to-head comparisons of all treatment options is not feasible. Thus, network meta-analyses play an important role in allowing health-care decision makers to compare the effectiveness of treatment options.

Objectives: A Bayesian network meta-analysis (NMA) was developed from studies identified from a systematic literature review (SLR) to evaluate the efficacy of once weekly oral selinexor with once weekly bortezomib and low-dose dexamethasone (XVd) relative to other therapies in previously treated MM.

Methods: Ovid was systematically searched for phase 2-3 randomized clinical trials (RCTs) in MM that assessed progression-free survival (PFS), overall survival (OS) and overall response rates (ORR). Two population subsets were assessed: second-line patients (2L) and third-line or greater patients (3L+). Base case results compared all regimens against twice weekly bortezomib and dexamethasone (Vd) as the anchored comparator regimen.

Results: Forty-seven RCTs met inclusion. For 2L PFS, OS and ORR, XVd had, on average, out of all iterations, the 6th (out of 21), 4th (out of 15), and 5th (out of 20) best result, respectively, versus Vd. For 3L+ PFS, OS and ORR, XVd had the 12th (out of 24), 11th (out of 22), and 8th (out of 25) best result, respectively, versus Vd. There was no statistically significant difference between XVd and other top-ranking therapies for PFS, OS, and ORR in either 2L and 3L+ except for daratumumab/bortezomib/dexamethasone [DVd], which was favorable versus XVd (2L PFS only).

Discussion: Results for XVd were more favorable in 2L, having a higher probability of being a top 5 regimen, compared with 3L+ therapies based on the reported clinical trial results. However, in typical clinical practice, most triplet regimens have been modified using weekly bortezomib dosing, raising questions about the actual efficacy of these regimens versus the reported results using twice weekly bortezomib dosing.

Conclusions: The addition of XVd, which was designed with once weekly bortezomib dosing, to the treatment landscape for previously treated MM provides a regimen that may potentially be noninferior to the other top 5 regimens in both 2L and 3L+ settings and is associated with less peripheral neuropathy.
Efficacy of fungicides against brown spot on walnuts in the Western Forest-Steppe of Ukraine
Authors: Skoreyko A. , Andriychuk T. , Bilyk R.
Published: August 2021

Goal. To study the effectiveness of fungicides against brown spot of walnut in the Western Forest-Steppe of Ukraine.

Methods. The studies were carried out during 2018—2019. in agrocenoses of the walnut garden of the Ukrainian Research Station of Plant Quarantine of the Institute of Plant Protection of the NAAS. At the detailed account inspected not less than 3—4 accounting trees from four parties of a crown and analyzed on 25 accounting bodies (leaves, shoots, fruits) and determined intensity of defeat. The study of the effectiveness of fungicides against brown spot was carried out on the nut variety Bukovynsky 2 using drugs: Bordeaux liquid, 1-percent solution — the standard; Kuproksat, s. c., (copper sulphate tribasic, 345 g/l), Medyan Extra 350 SC s. c., (copper chloride, 350 g/l).

Results. Defeat of leaves at the last account in variants with the drug Medyan Extra 350 SC s. c., decreased in comparison with control in 2.6 times, development of a disease — in 2.8 times. By all indicators, the variant with the drug Kuproksat, hp was more effective, where the brown leaf spot was 20.5% (64.5% in the control), the disease was 9.3% (31.4% in the control). Fetal damage in the last account in the experimental variants was respectively 2.7—3.9 times less, and the development of the disease — 3.1—4.2 times weaker than in the control.

Conclusions. The obtained data show that in the conditions of the western Forest-Steppe of Ukraine the application of fungicides on walnut both in the experimental and in the reference variants provided good and approximately identical protection of the nut against brown spot Ophiognomonia leptostyla (Fr.) Sogonov. The effectiveness of fungicides was the highest in the variant with the drug Kuproksat, hp, (on the leaves — 70.4%, on the fruits — 75.9%). Technical efficiency of the drug Medyan Extra 350 SC, s. c. on leaves and fruits was 64.6 and 67.9%, respectively. Fungicide treatment of experimental plots helps to reduce the incidence of the disease, which makes it possible to obtain a yield of 0.9—1.1 t/ha higher than in the control.
The conducting pheromone monitoring of the main pests of the orchard
Authors: Borzykh A. , Tkalenko G. , Kirichuk I. , Chelombitko A.
Published: August 2021

Goal. Analysis of the latest methods for identifying pests of an orchard using pheromone monitoring and factors affecting its implementation.

Methods. The studies were carried out in accordance with modern methodological approaches to pheromone monitoring of pests of fruit plantations.

Results. The principles of pheromone monitoring in an orchard are given to identify harmful and quarantine organisms, which makes it possible to obtain information about the presence of pests in a certain area, determine their number, development dynamics, and, on the basis of the data obtained, plan and carry out appropriate phytosanitary measures. The main pests of the orchard of the Lepidoptera and Hemiptera classes have been identified, monitoring of which is carried out using pheromone traps. Methodological recommendations are given for conducting pheromone monitoring in fruit plantations to identify the eastern fruit moth (Grapholitha molesta Busck), Californian and mulberry scale insects (Pseudaulacaspis pentagona Targ.-Tozzetti, Quadraspidiotus perniciosus Comst), American white butterfly (Hyphantria cune). The advantages of the pheromone method over other monitoring methods are presented. The main factors that affect the catch of pests with pheromone traps are described.

Conclusions. The information obtained with the help of pheromone traps is a component of effective programs — systems of integrated plant protection against pests, which combine the use of a complex of biological, chemical, agrotechnical measures, as well as fundamental for planning measures to prevent emergencies in a phytosanitary state. The informativeness and reliability of pheromone monitoring makes it possible to substantiate and develop instrumental monitoring technologies that reduce the number of chemical treatments by up to 30%, increase labor productivity by 75%, reduce costs by 70%, and increase the efficiency and reliability of accounting.
The Hague Rules on Third-Party Joinder: A Revised Framework
Authors: Macfarlane Emma
Published: August 2021

This paper critically assesses the Hague Rules’ stance on third-party joinder. Third-party joinder is an important feature in business human rights disputes. It is a mechanism that victims of human rights abuses can use to bring claims against corporate defendants where the victims do not otherwise have an underlying agreement on which to base their claim. Keeping in line with traditional conceptions of commercial arbitration, the Hague Rules are grounded in party consent to arbitrate. Conceptions of consent therefore have an outsized impact on the universe of parties who can bring actions against corporations before arbitral tribunals for human rights abuses. The main objective of this paper is to offer an alternative framework of third-party joinder and consent to achieve a better balance between the interests of claimants alleging human rights abuses and corporate defendants.

Part I traces the rise of arbitral tribunals as fora for business human rights disputes. Part II outlines the procedural shortcomings of third-party joinder in business human rights cases before arbitral tribunals under the Hague Rules. Part III advocates for a new framework to guide arbitral tribunals when assessing whether to allow requests for third-party joinder.
Mathematical model for determining production capacities
Authors:   Zagidullin R.R.
Published: August 2021

The process of creating a mathematical model using a linear programming apparatus for determining the technological capacities of an enterprise at the manufacture of machine-building products is considered.

Keywords
mathematical model; capacity task; mathematical programming; machine-building
Control of ground objects escorting from aircraft
Authors:   Alesov M.B.
Published: August 2021

The synthesis problem of adjuster for software automatic escorting of a ground mobile object using a surveysearch system of an aircraft is considered. The calculation of the control function is carried out by the method of the inverse dynamic problem separately for two angular channels. It is proposed to take into account the restrictions on the magnitude of the control action and on the angles of the line of sight, as well as to use the nonlinear Lewis equation with a correcting differential term as a reference equation.

Keywords
software support; synthesis of program control; method of the inverse dynamic problem
EXPERIENCE OF FOLLOW-UP MONITORING OF COVID-19 CONVALESCENTS (LONG COVID SYNDROME)
Authors:   Institution of Internal and Preventive Medicine – Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, 175/1 B.Bogatkova str., 630089, Russia, Logvinenko Irina
Published: August 2021

Abstract: Various clinical scenarios of the course of the post-COVID syndrome in the period of convalescence were studied. The frequency and volume of studies in combined pathology in patients who have undergone COVID-19 are considered. The controlled indicators of the medical state within the framework of follow-up monitoring and the minimum frequency of follow-up visits were clarified. Key words: New coronavirus infection, convalescents, the long COVID syndrome, follow-up monitoring
LOGICAL AND INFORMATION MODEL OF MANAGEMENT OF PROCESSES OF «SMART» PRODUCTION
Authors:   Kazan National Research Technological Universit, Nurgaliev R.K. , Shinkevich A.I. ,   Kazan National Research Technological Universit
Published: August 2021

The article presents a study of the specifics of «smart» production, the positive effect of which is certainly recognized by industrial enterprises. This means increasing production efficiency, ensuring the reliability, stability and safety of technological systems, and reducing the burden on the environment. In the context of the digital transformation of the industry, new opportunities are opening up to achieve this effect. In this regard, it is important to model the processes of «smart» production, the decomposition of the control system of mechanisms and tools. The purpose of the study is to build a logical and information model that reflects the specifics of managing the processes of «smart» production. The research methods used are comparative analysis (in the context of industries and territories); formalization, which clearly presents information about the management of «smart» production processes in the form of schemes and models; mathematical and statistical methods that underlie cluster analysis. As a result of the study, the following results were obtained: the general scheme of «smart» production was formalized, taking into account the processes of obtaining a petrochemical product, control actions, mechanisms and necessary resources, taking into account the guidelines for sustainable development; the typology of Russian regions, depending on the level of intellectualization of production, was identified according to the signs of the activity of organizations in terms of the use of information and communication technologies for the automation of processes and design: regions with low, medium and high activity of intellectualization of production; A logical and information model of managing the processes of «smart» production is proposed, covering the stages of integration and operation of digital technologies, production assets of industrial enterprises and personnel support, which differs in the object of modeling and systematically describes the functioning of intelligent production. The practical significance of the results is due to the possibility of competent process management in the context of the implementation of digital solutions and the sustainable development of industry.
PECULIARITIES OF FORMATION AND ACTIVITIES OF COMMAND STAFF OF THE RED ARMY DURING THE CIVIL WAR
Authors:   Samara State Technical University, Pilipenko S.A.
Published: August 2021

The author considers the main sources of replenishment of command personnel, the methods of engagement and maintenance of discipline among commanders. He reveals the main problems facing the red officers, analyzes the social status of the command staff and the relationships between military commanders and commissars.
ELABORATION OF CONCEPTUAL FOUNDATIONS FOR THE EDUCATION OF OFFICERS IN THE SPIRIT OF LOVE FOR THE MOTHERLAND BY MILITARY-POLITICAL LEADERS OF THE WHITE MOVEMENT
Authors:   Povolzhskiy State University of Telecommunications and Informatics, Zajkina T.V.
Published: August 2021

The author uses the methods of historical study to consider the specifics of the approach of the White movement leaders to educating their officers in the spirit of love for the Motherland during the civil war in Russia in the beginning of the XX century. On the base of the analysis of historical sources, the author traces the continuity of the ideological base of the White movement from the military-patriotic education of tsarist Russia, but also distinguishes its subjective and objective features.
SOVIET-GERMAN COOPERATION IN THE FIELD OF HYDRO-TURBINE ENGINEERING IN THE 1920s
Authors:   Peter the Great St. Petersburg Polytechnic University, Ganin M.A.
Published: August 2021

In December 1920, the GOELRO plan was adopted: a long-term plan for the electrification of the country, which was supposed to form the necessary prerequisites for the industrial development of the young Soviet state. The development of hydropower played an important role in this, however, without the necessary technologies and experience in building large hydro turbines, the Soviet state would have been forced to acquire them abroad, and thus inevitably fell into dependence on the advanced Western countries. In this regard, it was decided to develop Soviet own hydro-turbine-building enterprises (one of the key ones among which was the Leningrad Metal Plant), attracting foreign assistance whenever it was possible. Cooperation was started with the German company «Fritz Neumeyer», which was ready not only to supply finished products, but also to carry out technical cooperation. This article contains an attempt to consider the prerequisites for cooperation of the Leningrad Metal Plant with the company «Fritz Neumeyer», to determine the key areas of the transfer of technologies of hydro-turbine engineering between Leningrad Metal Plant and the «Fritz Neumeyer» at various stages, and to assess the impact of this cooperation on the establishment and development of national hydro-turbine development.
The dietary supplement of Ginkgo biloba: a comprehensive review of its potential interactions based on pre-clinical and clinical evidences
Authors:   Imam Abdulrahman Bin Faisal University, Ahmad Rizwan , Alsadah Hawra Adnan ,   Imam Abdulrahman Bin Faisal University, Riaz Muhammad ,   Shaheed Benazir Bhutto University, AlLehaibi Lina Hussain ,   Dammam Medical Complex, Alraya Reem Ahmed ,   King Fahad Specialist Hospital, Aljamea Ahmed ,   Imam Abdulrahman Bin Faisal University, Zahoor Saira ,   Imam Abdulrahman Bin Faisal University
Published: August 2021

This review present Gingko biloba (GB) interactions, based on clinical and pre-clinical presentations. Literature was retrieved using databases; ScienceDirect, PubMed, Google scholar, Web of Science, Scopus etc. 14/45 interactions were found with clinical presentations. More interactions (80%) were reported with drugs followed by herbs (11.1%), and nutraceuticals (6.7%) with major mechanisms of interaction observed as; inhibition of Cytochrome metabolizing enzymes (44.4%) and platelet-activating factor (PAF) i.e. 15.6%. Major clinical features were; increased bleeding (eye, parietal), hematomas (subdural), and seizures as well as increased blood pressure, priapism, loss of infection/antiviral failure, and coma. Drugs with major interactions belonged to anti-platelet/anti-coagulant and NSAIDs. Synergistic effects were observed for GB vs herbs (except cannabis which showed rhabdomyolysis), foods, and nutraceuticals (except pyridoxine where neurotoxicity was seen). GB use should be monitored and the patient may seek proper advice from a healthcare professional.
Structural elucidation, mechanism of action, antibacterial proficiency and synergistic forte of purified Euphorbia hirta whole plant extract against multi-drug resistant otitis media infection
Authors:   Federal University of Technology, Oseni Adedoyin , Olusola-Makinde Olubukoka ,   Federal University of Technology, Oladunmoye Muftau ,   Federal University of Technology
Published: August 2021

This study investigated the antibacterial potential of Euphorbia hirta whole plant extracts, honey and conventional antibiotics and their synergistic effects against selected multidrug resistant and typed bacterial strains associated with otitis media. E. hirta whole plant extract was purified using column chromatography technique. The antibacterial assays of extracts were done using standard microbiological procedures. Protein, sodium and potassium ion leakage of the synergistic mixtures was determined using flame-photometry. At 100 mg/ml, acetone extracts presented highest inhibition against S. aureus (NCTC 6571) with 32 ± 0.83 mm zone of inhibition. The fractional inhibitory concentration indices displayed higher synergism in combination of plant extract, honey and ciprofloxacin against P. mirabilis at 0.02 compared to drug combination synergy standard (≤ 0.5). This work revealed augmentation of ciprofloxacin potency when combined with purified E. hirta acetone extract and honey and implies their high potential in the treatment of multidrug resistant infection of otitis media.
Effect and safety of an outpatient traditional medicine treatment for asthma in 26 patients from Cota, Colombia: a case series
Authors:   Universidad del Rosario, Zuluaga German , Pimentel Juan ,   Universidad del Rosario, Sarmiento Ivan ,   Universidad del Rosario, Andersson Neil ,   Universidad de McGill
Published: August 2021

The prevalence, morbidity and costs of asthma care have increased worldwide. This study describes the effect and safety of an outpatient medical treatment with traditional medicine for asthma, through a retrospective case series with patients admitted to outpatient consultation from 1995 to 2015 in Cota, Colombia. Analyzing 26 cases with a clinical diagnosis of asthma, during the treatment 34.6% (9/26) did not present episodes of uncontrolled asthma and 61.5% (16/26) were classified as controlled asthma in their last consultation of control. 88.4% (23/26) of the patients reported no adverse reactions and the three reported were mild. The results allow to generate hypotheses about the effectiveness and safety of an outpatient treatment based on the incorporation of resources from traditional medicine. These observations could be explored with experimental studies to determine their long-term effectiveness, safety and low cost.
İLKOKUL ÖĞRENCİLERİNİN OKUDUĞUNU ANLAMA BECERİSİ İLE OKUMA KAYGISI ARASINDAKİ İLİŞKİDE OKUMA ALIŞKANLIĞININ ARACI ROLÜ
Authors: ESEN AYGÜN Hanife
Published: August 2021

Bu araştırmada, okuma becerisinin bilişsel gelişim üzerindeki etkilerinden hareketle, ilkokul öğrencilerinin okuduğunu anlama becerisinde, okuma kaygısı ve okuma alışkanlıklarının rolünü incelemek amaçlanmıştır. Veriler, 2018–2019 eğitim-öğretim yılında Çanakkale il merkezinde öğrenim gören ilkokul dördüncü sınıf öğrencilerinden toplanmıştır. Araştırmaya 403 öğrenci katılmıştır. Araştırma verilerinin toplanmasında, Okuduğunu Anlama Testi, Okuma Kaygısı Ölçeği ve İlkokul Öğrencileri için Okuma Alışkanlığı Ölçeği kullanılmıştır. Modelin uyumu yapısal eşitlik modellemesi ile test edilmiştir. Bu araştırmadan elde edilen sonuçlara dayalı olarak, okuma alışkanlığının okuduğunu anlama becerisini ve okuma kaygısının okuduğunu anlama becerisini anlamlı düzeyde yordadığı anlaşılmaktadır. Bununla birlikte, okuduğunu anlama becerisi ile okuma kaygısı arasındaki ilişkide okuma alışkanlığının aracı rolünün olduğu anlaşılmaktadır. Bu sonuca bağlı olarak, ilkokul dördüncü sınıf öğrencilerinin okuduğunu anlama becerisinde okuma alışkanlığı ve okuma kaygısının rol oynadığı anlaşılmaktadır.