bluuebunny/crossref_metadata_2025 huggingface dataset:
Performance Analysis of the Milk Pasteurization Process Using a Flat Plate Solar Collector
Authors: Tigabe Surafel , Bekele Addisu , Pandey Vivek
Published: September 2022

A large share of Ethiopia’s milk production comes from its rural areas. However, this milk does not undergo further processing into dairy products on a large scale due to lack of conventional energy sources such as electricity and gas. Hence, the country is not utilizing its milk resources to the maximum possible. In this study, the possible use of solar energy for the milk pasteurization process is investigated by using a flat plate solar collector (FPSC) with and without reflectors integrated. Reflectors added to the FPSC have augmented the incident solar radiation on the collector from 0.27–0.91 kW/m2 to 0.36–1.18 kW/m2. The thermal efficiency obtained for the FPSC with reflectors integrated is 51.8% whereas that of the collector without reflectors integrated is 46.2%. Likewise, the exergy efficiency is found to be 5.43% for the collector integrated with reflectors and 2.53% for the collector without reflectors. Also, an increase in the daily processed milk production of 18% is observed in September and 16% in November by using the solar collector with reflectors integrated. The quality of pasteurized milk is checked by using the methylene blue reduction test (MBRT) method, and it indicates a better quality of pasteurized milk when compared with raw milk. Therefore, this study shows that the use of solar energy for milk pasteurization has great potential to increase the shelf life of milk, and it can be used as an instrument to improve the quality of life of people living in rural areas.
Investigating Antimicrobial Resistance and ESBL Producing Gene in Klebsiella Isolates among Neonates and Adolescents in Southern Bangladesh
Authors: Tanni Afroza Akter , Sultana Nahid , Ahmed Wazir , Hasan Md. Mahbub , Hossain Md. Shakhawat , Noyon Sajjad Hossain , Hossain Md. Mobarok , Mannan Adnan
Published: September 2022

Background. Multidrug-resistant (MDR) clones of Klebsiella pneumoniae (Kpn) have been increasingly documented in community-acquired and nosocomial infections all around the globe. Extended-spectrum β-lactamases (ESBLs) are a rapidly evolving group of β-lactamase enzymes derived from SHV genes by mutations. This research work aimed to investigate and analyze the widespread prevalence of Kpn antibiotic resistance in different areas of the southern part of Bangladesh. Methods. This particular study was executed and implemented by using 501 clinical samples or isolates from two different hospitals in Chattogram. The disk diffusion method was used to detect Kpn’s sensitivity to 16 antibiotics in a drug susceptibility test. By using the PCR technique, the widespread prevalence of antibiotic-resistant gene blaSHV-11 was studied. Sequencing along with phylogenetic analysis was utilized to verify isolates with the blaSHV-11 gene. Results. Almost all of the Kpn isolates were spotted to be antibiotic-resistant. These Kpn isolates were resistant to β-lactams, aminoglycosides, and quinolones at high levels. The spatial analysis displayed that infections involving Kpn were more common in the urban areas (70%) than in the rural areas (30%). Neonates had substantially higher levels (

p
<
0.001

) of resistance to multidrug than other age groups. Cefepime was identified as the most frequent antibiotic-resistant to all age groups (56.68%). The highest numbers of resistant isolates (36.92%) were found in urine samples. The ESBL gene blaSHV-11 was found in 38% isolates. Conclusion. The significant frequency of MDR Kpn harboring β-lactamases and AMR genes strongly suggests the requirement to develop effective antimicrobial resistance control and prevention measures in Bangladesh.
On the Intelligent Computing Model of Diagnosis Teaching in Preschool Education in Colleges and Universities under the Background of Big Data
Authors: Ding Xiaoqiong
Published: September 2022

In order to infer the cognitive state of students and provide teachers with the potential learning state of students, a diagnostic teaching model for preschool education in colleges and universities under the background of big data is proposed. By increasing students’ programming ability and modeling students’ theoretical and practical abilities at the same time, the cognitive diagnosis is introduced into the field of computer teaching, so as to make it applicable to computer classrooms and provide students’ cognitive information needed for teaching. The experimental results show that the advantages of the CDF-CSE approach gradually emerge as the training data become sparse (the proportion of training data decreases from 80% to 20%). In the combined questions of the three datasets, when the training set is 20% and MAE is used as the criterion, the CDF-CSE model improves by 47.8%, 65.8%, and 49.8%, respectively, compared with the other methods that perform best on the training set. When the number of questions is small, the CDF-CSE model improves by 37.8%, 42.5%, and 27.7% on RMSE on three datasets, respectively, compared with the best-performing other methods. When there are more questions, it has 32.3%, 36.5%, and 45.6% improvement, respectively. It is concluded that this model can accurately predict students’ performance in computer courses and provide detailed and rich cognitive reports.
[Retracted] Role of Medical IoT‐Based Bone Age Determination in the Diagnosis and Clinical Treatment of Dwarfism Disease Monitoring
Authors: Wu Shaoxia
Published: September 2022

Currently, the prevalence of dwarfism in children in China is about 3%, which is a very large percentage compared with the large population base. With the increase of influencing factors, the prevalence of dwarfism is on the increase. However, there is a lack of awareness of dwarfism among parents and a lack of in‐depth analysis of the causes of dwarfism and a low level of treatment among doctors. Early expert system knowledge base relies on manual editing, which is a traditional, semi‐intelligent auxiliary diagnostic system, and is unable to perform disease diagnosis and clinical treatment monitoring well. Many studies have turned to the combination of IoT for bone age determination and its role in the diagnosis and monitoring of clinical treatment of dwarfism. In this study, 15 children with short stature who underwent health checkups at a hospital were enrolled in the study, and a G‐P spectrum method was used to determine the bone age of all the enrolled subjects, and the results obtained in the process of bone age determination were systematically analyzed. The results showed that the bone age measurement technique has sufficient reference value for evaluating the quality and diagnosing diseases, and the research and development of this technique is of great significance for the development of modern clinical medicine.
Digital Management and Optimization of Tourism Information Resources Based on Machine Learning
Authors: Zhuang Xueqiu , Jiao Huihua , Kang Li
Published: September 2022

With the gradual growth of economy, tourism has become a pillar industry in many countries and plays an important role in promoting national development. The individualization and diversification of tourism resources must be supported by a powerful information resource management system. However, the traditional tourism information resource management system has some problems, such as scattered sources of tourism information, low interactivity, and slow update of information resources. Tourists cannot get detailed information of scenic spots and make detailed plans for tourism which hinder the further development of the tourism industry. In order to solve these problems and promote the development of the tourism industry, this paper carried out digital management of tourism information based on machine learning and digital management of information resources of different tourist attractions and surveyed and tested the number of tourists, expenditure of scenic spots, income of scenic spots, and satisfaction of tourists. The total result showed that the digital management of tourism information resources in scenic spots can increase the passenger flow, increase the income of scenic spots, reduce the expenditure of scenic spots by 6.7%, and increase the satisfaction of tourists by 4.1%. The digital management of tourism information resources based on machine learning can optimize the tourism industry and promote its development.
[Retracted] Objective Evaluation of CT Imaging in the Treatment of Lumbar Disc Herniation
Authors: Tao Guilan , Shi Hui , Cui Juanjuan , Wu Ruixian
Published: September 2022

The value of CT imaging in evaluating the efficacy of percutaneous transforaminal endoscopic discectomy (PTED) in the treatment of lumbar disc herniation (LDH) is explored. A total of 105 patients with LDH admitted to our hospital from March 2018 to September 2019 are selected for treatment with PTED, and all patients undergo CT examination before and after surgery. The CT imaging parameters (CT value of spinal canal soft tissue shadow, maximum back shift distance, longitudinal axis length, and intervertebral space height) before and 1 week after operation, the Japanese Orthopaedic Association (JOA) scores before and 6 months after the operation are compared, and the excellent and good rate of the operation effect is calculated. The correlation between JOA score and CT imaging parameters are analyzed by Pearson correlation method. The experimental results prove that PTED is effective in treating LDH. CT imaging can quantitatively measure the data of herniated intervertebral discs to clarify the recovery of the compressed dural sac and nerve roots, and the results are highly consistent with JOA score, which can be used as PTED objective evaluation method for the treatment of LDH.
Application of Quantitative Assessment Strategy-Based Nursing Combined with Empathic Nursing in Patients Undergoing Tension-Free Inguinal Herniorrhaphy
Authors: Xiang Yamei , Xi Lingyun
Published: September 2022

Objective. This study aimed to explore the application of quantitative assessment strategy-based nursing combined with empathic nursing in patients undergoing tension-free inguinal herniorrhaphy. Methods. 82 patients who underwent tension-free inguinal herniorrhaphy in our hospital from May 2020 to December 2021 were enrolled. According to the random number table method, they were divided into three groups (A, B, and C). Patients in group A received quantitative assessment strategy-based nursing combined with empathic nursing, and group B received quantitative assessment strategy-based nursing. Group C received a routine intervention. The early recovery of the three groups was observed. Heart rate (HR), oxygen saturation (SpO2), and blood pressure (BP) were recorded before entering the operating room and at the beginning of anesthesia. Mental Health Continuum-Short Form (MHC-SF, adult version) was used to assess the psychological status. The Modified Barthel Index (MBI) score of three groups at different time points was recorded. The complications of the three groups were observed. Results. Compared with group C, wound healing time, ambulation time, hospital stay time, and time to resume daily activities in groups A and B were significantly shorter (all

P
<
0.05

). At the beginning of anesthesia, HR and BP levels in the three groups were all decreased, with HR and BP levels in group A lower than those in group C and HR levels in group B lower than those in group C (all

P
<
0.05

). After the intervention, the scores of emotional well-being, psychological well-being, and social well-being in groups A and B were higher than those in group C and the scores of psychological well-being and social well-being in group A were higher than those in group B (all

P
<
0.05

). The daily living ability score of group A was higher than that of groups B and group C at discharge, one month after discharge, and three months after discharge, and the daily living ability score of group B was higher than that of group C at these three time points (all

P
<
0.05

). No significant differences were observed in the incidence of complication rate among the three groups (10.71%, 14.81%, and 29.63%) (χ2 = 3.616, all

P
>
0.05

). Conclusion. Quantitative evaluation strategy-based nursing combined with empathic nursing can effectively improve the early recovery of patients undergoing tension-free inguinal herniorrhaphy, reduce their stress response, and improve their mental health and daily living ability.
[Retracted] Text Score Analysis under the IPE Environment Based on Improved Transformer
Authors: Qi Jinghong , Jia Xinli
Published: September 2022

In order to improve the accuracy of ideological and political education (IPE) text scoring, an improved short‐text similarity calculation model based on transformer is proposed. This model takes the DSSM model as the basic framework and uses the Bert model to realize text representation and solve polysemy problem. The transformer encoding component is used to extract the characteristics of the text and obtain the internal information of the text. With the help of the encoding component, the two texts can interact with information on multiple levels. Finally, the semantic similarity between two texts is calculated by concatenation vector inference.
Construction of Facial Expression Recognition Technology of Intelligent Service Robot Based on Nanofiber Flexible Wearable Electronic Skins
Authors: Li Feigao , Li Chenyang , Liu Yue
Published: September 2022

Recognizing human features is a highly significant and popular research topic in academia today, especially with regard to human intervention and computer intelligence. If you want your computer to have real intelligence, then the computer must first learn to understand human feelings, and facial expressions often contain rich emotional information. Clearly, recognizing human features is indispensable for the future intelligent development of computers. There are always a few components and many researchers are involved. Compared with the traditional facial expression recognition method, which needs to manually define features and artificially perform appropriate feature extraction, a great advantage of deep learning is to remove the disadvantages that require a lot of human intervention, thereby reducing the uncertainty of expression recognition. In recent years, deep processing has led to outstanding gains in numerous domains, including robotics, computer graphics, and natural language processing. Therefore, this article applies a popular recognition algorithm based on deep learning, combined with a nanofiber flexible wearable electronic skin, and applies it to the field of facial expression recognition. Functional expression identification is an essential goal of the external analysis of human features. Mature facial expression recognition technology has great application values.
The Selecting Optimal Ball-Receiving Body Parts Using Pose Sequence Analysis and Sports Biomechanics
Authors: Du Hui
Published: September 2022

The purpose is to explore a personalized and targeted training mode in football player training. Firstly, this work introduces the principle and advantages of machine vision sensing. Secondly, from the biomechanical point of view, the influence of the acceleration of several joints and the joint angle on the ball receiving effect is analyzed. Furthermore, the football player’s in-game receiving image is collected using machine vision technology, and the pose image data are preprocessed to construct a data set. Then, a new model is constructed and trained using Haar-like feature (HLF) and (Adaptive Boosting (Adaboost). Finally, the recognition model of the football receiving pose is tested, and the recognition effect is compared with the mainstream recognition model. The results show that the recognition parameter of the traditional method based on the Halcon recognition pose system is 5.12 at 20 times and then begins to decline. In contrast, the identification parameters based on the Industrial Robot Vision System Development (IRVSD) platform are much higher than those based on Halcon. It slightly decreases when the training times are 60 and then gradually increases. However, the recognition parameters based on the proposed machine vision have been far higher than those of the two traditional methods and maintained at about 10. This is because the proposed method extracts the foul image features, establishes the pose sequence potential function, and analyzes it in more detail, thus improving the recognition accuracy. The player’s pose recognition model based on HLF and AdaBoost algorithm can identify and evaluate the ball-receiving pose, thus guiding the receiving improvement. The finding shows that the proposed recognition technology can recognize and evaluate the players’ ball-receiving image, providing a new direction for applying artificial intelligence technology in sports.
A Case of Glycogenic Hepatopathy as a Complication of Poorly Controlled Type 1 Diabetes Mellitus
Authors: Munugoti Samhitha , Reddy Vamsee , Patel Gaurav , Gaddam Maneesh , Abburi Triveni
Published: September 2022

A 23-year-old African American male with a medical history significant for poorly controlled type 1 diabetes mellitus (T1DM) presented with abdominal pain and vomiting. His laboratory workup was consistent with diabetic ketoacidosis (DKA). An acute elevation of liver enzymes was noted as the DKA resolved, with the alanine transferase and aspartate transferase levels elevated to more than 50 times the normal limit within the next 24 hours. Because abnormal liver function tests are found frequently in patients with type 1 diabetes mellitus, it is important to have a broad differential diagnosis. Furthermore, a low threshold of suspicion is required to identify a relatively underdiagnosed etiology like glycogenic hepatopathy (GH). This case report describes how patterns and trends of liver function tests provide important clues to the diagnosis of GH; how imaging modalities like ultrasonography, computerized tomography (CT) scan, and magnetic resonance imaging (MRI) scan could be used to differentiate GH from nonalcoholic fatty liver disease (NAFLD); and how the diagnosis of GH can be made without the need for invasive liver biopsy. The knowledge about GH should prevent its delayed diagnosis and improve the outcomes by appropriately managing uncontrolled type 1 DM.
Spatial Differentiation of Ecological Stoichiometry of Nitrogen and Phosphorus in Mollic Epipedon of China
Authors: Du Huishi
Published: September 2022

Nitrogen (N) and phosphorus (P) are essential elements for crop growth. The study on the spatial differentiation characteristics of soil N and P can provide a theoretical basis for regional fertilization as well as prevention and control of agricultural surface pollution. Taking the typical mollic epipedon area in Northeast China as study area, using the geostatistical model and 3S technology (Remote Sensing, RS; Geography information systems, GIS; and Global positioning systems, GPS), the spatial variation and influencing factors of N and P ecological stoichiometry in the surface soil (0-20 cm) were studied with 1,057 samples by five-point soil sampling method. The outcomes of the study showed that the average total nitrogen (TN), total phosphorus (TP), and N/P ratio were 1.88 g/kg, 0.276 g/kg, and 6.81, respectively. The degree of spatial variation is moderate, and structural factors such as topography and soil parent material are the main factors affecting the spatial variation of soil TN, TP content, and N/P ratio. Vegetation primarily affects the soil TN, TP contents, and N/P specific spatial variation. Soil TN and TP contents showed a downward trend from the northeast to the southwest region of the study. Different approaches of balanced fertilization, soil and water conservation, and reasonable spatial allocation are beneficial to improving the balance of soil N and P in the typical mollic epipedon area of Northeast China.
Comparison of Different Therapeutic Effects of T‐MIST for Chronic Idiopathic Tinnitus
Authors: Liang Chaoqun , Fang Qi , Chen Hongjun , Wang Zhixian , Yang Jianming
Published: September 2022

Objective. Tinnitus, as a common clinical symptom, has the characteristics of high incidence and great heterogeneity among different patients. As one of the common treatment strategies for tinnitus, this study is aimed at exploring the factors influencing tinnitus sound therapy and the correlation between different tinnitus acoustic characteristics. Methods. 315 patients with chronic tinnitus were enrolled and divided into three groups according to the tinnitus multielement integration sound therapy (T‐MIST): (1) vanishing, (2) remission, and (3) unchanged. The general characteristics, psychoacoustic scores (tinnitus handicap inventory (THI) and visual analog scale (VAS)), residual inhibition (RI), degree of hearing loss, and tinnitus characteristics of each group were compared. Finally, we analyze the predictive significance of different features for acoustic effects. Results. The frequency of tinnitus in the vanishing group was higher than that in the remission and unchanged groups (P < 0.05). There were no differences in age, initial onset time, course of the disease, and VSAD between the vanishing group and the unchanged group (P > 0.05). High‐frequency tinnitus may predict the vanishing of tinnitus after treatment (P < 0.05), but the degree of hearing loss, tinnitus characteristics (loudness and frequency), and psychoacoustic score (THI and VAS) were only weakly correlated (P < 0.05). Residual inhibition test (RI) was an independent risk factor for the efficacy of acoustic therapy (P < 0.001). Conclusion. The patients were divided into three groups by T‐MIST treatment effect; Kruskal‐Wallis test and chi‐square test were used to compare the baseline information of each group. Then, we analyzed the correlation between patient characteristics and psychoacoustic scores. Finally, logistic regression was performed to explore predictors that might influence the treatment effect. High‐frequency tinnitus may have a better therapeutic effect; age, disease course, and other factors can not be stable explanation factors for a poor therapeutic effect of tinnitus. The residual inhibition (RI) test was an independent factor in predicting the efficacy of T‐MIST.
[Retracted] Safety and Efficacy of CT‐Guided Central Venous Catheter Gastric Insufflation in Percutaneous Gastrostomy
Authors: Zhang Wen , Deng Ruoyu , Chen Boyu , Lv Jialing , Zhu Tingbiao , Huang Meifang , Xu Guoyu , Liu Feineng , Zhang Tengfei , Wang Lin , Yue Jun , Mu Lixia , Zhang Chao
Published: September 2022

Gastric insufflation for computed tomography (CT)‐guided percutaneous gastrostomy is currently performed via a nasogastric tube or a Chiba needle. However, nasogastric tube placement requires patient pharynx and esophagus, and Chiba needle use is associated with an increased risk of organ damage and prolonged operation time. Herein, we introduce a new method of gastric insufflation via a central venous catheter and explore its safety and efficacy by retrospective analysis of the clinical data of patients who underwent percutaneous gastrostomy using this method in our hospital from April 2021 to March 2022. The extracted data included the following: success rate, operation time, gastric insufflation time, radiation dose, postoperative pain score, and complications. We also compared the preoperative levels of several nutritional indicators (body mass index, hemoglobin, albumin, creatinine, and blood urea nitrogen) with those obtained 1 month postoperatively. A total of 12 patients underwent percutaneous gastrostomy under CT guidance using central venous catheter gastric insufflation. The surgery and gastric insufflation success rates were 100% both. The average operation time, gastric insufflation time, and effective radiation dose were 24.08 ± 5.25 min, 5.08 ± 2.50 min, and 14.16 ± 3.63 mSv, respectively. Based on the World Health Organization scale for pain assessment, five patients reported no postoperative pain and seven patients had mild pain. There were no serious complications, such as stoma infection, peritonitis, gastrointestinal perforation and bleeding, or embedding syndrome. All evaluated nutritional indicators showed improvement at 1 month postoperatively, with statistically significant differences compared to the preoperative values (p < 0.05 for all). In conclusion, CT‐guided percutaneous gastrostomy with central venous catheter gastric insufflation is a safe, effective, and feasible minimally invasive treatment.
Artificial Bee Colony Based Gabor Parameters Optimizer (ABC-GPO) for Modulation Classification
Authors: AlJubayrin Saad , Sarfraz Mubashar , Ghauri Sajjad A. , Amirzada Muhammad Rizwan , Mezgebo Kebedew Teweldebrhan
Published: September 2022

Modulation classification is one of the essential requirements in the various cognitive radio applications where prior information about the incoming signal is unknown. The modulation classification using a pattern recognition approach can be achieved in 2 modules: first, parameters are extracted from the noisy signal, and then feature selection is carried out using a Gabor filter network (GFN). In the second module, features are exploited for classification purposes. The modulation formats considered for the purpose of classification are BPSK, QPSK, 8PSK, 16PSK, 64PSK, 4FSK, 8FSK, 16FSK, QAM, 8QAM, 16QAM, 32QAM, and 64QAM. The Gabor filter parameters and weights of the adaptive filter are attuned using the Delta rule and recursive least square (RLS) algorithm until the cost function is minimized. In the end, the artificial bee colony (ABC) algorithm is used to optimize the Gabor parameters as well as the classifier’s performance. The simulation results show the supremacy of the proposed classifier structure.
Influence of Marble Powder and Polypropylene Fibers on the Strength and Durability Properties of Self-Compacting Concrete (SCC)
Authors: Ali Atizaz , Hussain Zahoor , Akbar Muhammad , Elahi Ayub , Bhatti Samiullah , Imran Muhammad , Zhang Pu , Leslie Ndam Nembo
Published: September 2022

The purpose of this study was to investigate the effect of polypropylene fiber reinforced self-compacting concrete (SCC) at both the fresh and hardened stages, as well as their durability behavior. Properties of marble powder-based fiber reinforced SCC at fresh state were studied by means of slump flow diameter and flow time, V-funnel, and L-box test. The concrete properties at the hardened state were examined regarding compressive strength, split tensile strength, and flexural strength. Cement was replaced with marble powder with a substituting ratio of 4%, 8%, 12%, and 16% while polypropylene fibers were added as 0.1%, 0.2%, 0.3%, and 0.4%. The durability properties were analysed in the form of water permeability and chloride migration. In accordance with the outcomes of the tests, the workability of SCC deteriorated with an increase in fiber content, although it performed effectively at higher marble dosages. There was little impact of fibers on compressive strength and water permeability property of SCC. However, by adding the fibers in SCC improved both the split tensile strength and flexural strength by 16.92% and 11.36%, respectively. The addition of marble powder showed a synergetic effect with polypropylene fibers, which showed its applicability in SCC. The chloride resistance was improved at lower content of polypropylene fiber addition. For optimizing polypropylene fibers (pp) and marble powder substitution, the polynomial work expectation justifies the response surface technique (RSM). When a

p

value of 0.05 is used to analyse the variation in the (Linear-ANOVA), the model is considered statistically significant. Performance of concrete was greatly enhanced by substituting 12% marble powder with cement and adding 3% polypropylene fiber.
Identification of Significant Genes and Pathways for the Chronic and Subacute Cutaneous Lupus Erythematosus via Bioinformatics Analysis
Authors: Teng Yan , Li Sujing , Ding Yang , Fan Yibin , He Miao , Li Hengzhen , Tao Xiaohua , Huang Youming
Published: September 2022

Background. Chronic cutaneous lupus erythematosus (CCLE) and subacute cutaneous lupus erythematosus (SCLE) are both common variants of cutaneous lupus erythematosus (CLE) that mainly involve the skin and mucous membrane. Oral mucosal involvement is frequently observed in patients of CLE. Despite that they have different clinicopathological features, whether there is a significant difference in pathogenesis between them remains unclear. Herein, we investigated specific genes and pathways of SCLE and CCLE via bioinformatics analysis. Methods. Microarray expression datasets of GSE109248 and GSE112943 were both retrieved from the GEO database. Differentially expressed genes (DEGs) between CCLE or SCLE skin tissues and health controls were selected by GEO2R. Common DEGs were picked out via the Venn diagram software. Then, functional enrichment and PPI network analysis were conducted, and the top 10 key genes were identified via Cytohubba. Results. Totally, 176 DEGs of SCLE and 287 DEGs of CCLE were identified. The GO enrichment and KEGG analysis of DEGs of SCLE is significantly enriched in the response to virus, defense response to virus, response to IFN-gamma, cellular response to IFN-γ, type I IFN signaling pathway, chemokine activity, chemokine receptor binding, NOD-like receptor signaling pathway, etc. The GO enrichment and KEGG analysis of DEGs of CCLE is significantly enriched in the response to virus, regulation of multiorganism process, negative regulation of viral process, regulation of lymphocyte activation, chemokine receptor binding, CCR chemokine receptor binding, NOD-like receptor signaling pathway, etc. The top 10 hub genes of SCLE and CCLE, respectively, include STAT1, CXCL10, IRF7, ISG15, and RSAD2 and CXCL10, IRF7, IFIT3, CTLA4, and ISG15. Conclusion. Our finding suggests that SCLE and CCLE have the similar potential key genes and pathways and majority of them belong to IFN signatures and IFN signaling pathway. Besides, the NOD-like receptor signaling pathway might also have an essential role in the pathogenesis of SCLE and CCLE. Together, the identified genes and signaling pathways have enhanced our understanding of the mechanism underlying the occurrence and development of both SCLE and CCLE.
N-Cubic q-Rung Orthopair Fuzzy Sets: Analysis of the Use of Mobile App in the Education Sector
Authors: Madasi Joseph David , Khan Salma , Kausar Nasreen , Pamucar Dragan , Gulistan Muhammad , Sorowen Ben
Published: September 2022

This study analyzes the description to examine the results of a new study and create the technique and also demonstrate the effectiveness of this technique. In this ever-changing world, students are increasingly encouraged to use mobile phones primarily to learn for educational purposes. The learning process is continuous and the goal has now been achieved. It has been replaced by online learning. Due to mobile phones as well as the many feature-oriented applications, students can study at their own place and use the application to spend their time understanding, because everything is accessible with a single click. To carry on the study we applied mobile applications for online education system. Now, because the traditional method is taken into consideration, it is normal to carry a bag full of books and copies and immerse yourself in the tradition of learning to write. However, it has been found that not all students learn when he takes notes. Therefore, we must make sure that the student focuses only on one thing at a time. To continue the research, we apply the N-cubic structure to q-rung orthopair fuzzy sets in multi-attribute group decision-making problems. This structure solves the problems of multi-attribute group decision-making techniques more generally.
Programa Nacional de Prevención del Suicidio: el caso del suicidio en la vejez
Authors: Ociel-Moya Mario
Published: September 2022

En la búsqueda de problematizar algunos de los ejes del Programa Nacional de Prevención del Suicidio del año 2013, aun en vigencia, se abordan temas como: a) el criterio de edad como principio de selección y focalización de las actividades preventivas, y b) la ausencia en sus lógicas de intervención y ámbitos de acción que consideren elementos reactivos frente a factores contingentes, se busca instalar la necesidad de incorporar a la población envejecida dentro del segmento de población prioritaria en pos de la prevención del suicidio. Mediante un análisis de contenido del Programa Nacional de Prevención del Suicidio, este texto tiene como objetivos analizar la problemática del suicidio en personas mayores, mediante una revisión de políticas públicas.
Interpersonelles Therapeutenverhalten: Eine Untersuchung unterschiedlicher Konstrukte und zugrunde liegender Fähigkeiten
Authors: Wolfer Christine , Hilpert Peter , Flückiger Christoph
Published: September 2022

Hintergrund: Psychotherapeut*innen unterscheiden sich in ihrer Behandlungseffektivität gemessen am Therapieergebnis ihrer Patient*innen. Ein möglicher Faktor für Therapeuteneffekte scheint in den interpersonellen Fähigkeiten der Therapeut*innen zu liegen. Therapeuten-Assessments für interpersonelle Fähigkeiten konnten hinreichend prädiktive Validität nachweisen, bezüglich zugrunde liegender Fähigkeiten und verwandter Konstrukte ist hingegen wenig bekannt. Das Ziel der vorliegenden Studie ist der Vergleich unterschiedlicher Konstrukte interpersoneller Fähigkeiten sowie die Untersuchung möglicher zugrunde liegender Fähigkeiten. Studienpopulation und Methoden: In dieser explorativen Studie wird das Konzept der interpersonellen Fähigkeiten mit jeweils zwei unterschiedlichen psychologischen Konstrukten pro Erhebungsmethode (Selbstbeurteilungsfragebogen, Computertests und Assessments) erfasst. Hierfür wurden die sechs Maße der interpersonellen Fähigkeiten an 20 angehenden Psychotherapeut*innen sowie 28 Psychologiestudierenden (total N = 48) erhoben und die Zusammenhänge und Überlappungen der Konstrukte neben traditionelleren Methoden mittels partieller und Bayes’ Netzwerke untersucht. Ergebnisse: Es zeigen sich moderate bis hohe Zusammenhänge innerhalb der Selbstbeurteilungsmaße. Die Assessments zeigten jedoch keine Zusammenhänge mit den Selbstbeurteilungsmaßen und den Computertests. Diskussion und Schlussfolgerung: Die Übereinstimmungen in den Selbstbeurteilungen weisen auf stabile Selbstkonzepte interpersoneller Fähigkeiten hin, die sich jedoch nicht durch die erhobenen zugrunde liegenden oder fremdbeurteilten Fähigkeiten erklären lassen. Die nur geringfügige Korrelation zwischen den Assessments weist zudem darauf hin, dass interpersonelle, therapiebezogene Fähigkeiten situationsspezifisch zu interpretieren sind.
Microbial Keratitis following Self-Retained Cryopreserved Amniotic Membrane
Authors: Fairaq Rafah , AlBalawi Eman D. , Al-Swailem Samar A.
Published: September 2022

The aim of this study was to report a severe case of mixed fungal and bacterial microbial keratitis following implantation of a self-retained cryopreserved amniotic membrane, PROKERA® SLIM (Bio-Tissue, Inc) in a patient with history of neurotrophic ulcer secondary to herpetic epithelial keratitis. Despite maximally tolerated topical and systemic therapy, the patient’s eye continued to deteriorate and eventually required evisceration. PROKERA implantation might be associated with severe recalcitrant microbial keratitis. Caution is urged when considering implantation especially in monocular patients.
Evaluation of Outcomes of Peritoneal Dialysis Patients in the Post-COVID-19 Period: A National Multicenter Case-Control Study from Turkey
Authors: Ozturk Savas , Gursu Meltem , Arici Mustafa , Sahin Idris , Eren Necmi , Yilmaz Murvet , Koyuncu Sumeyra , Karahisar Sirali Semahat , Ural Zeynep , Dursun Belda , Yuksel Enver , Uzun Sami , Sipahi Savaş , Ahbap Elbis , Yazici Halil , Altunoren Orcun , Tunca Onur , Ayar Yavuz , Gok Oguz Ebru , Yilmaz Zulfukar , Kahvecioglu Serdar , Asicioglu Ebru , Oruc Aysegul , Ataman Rezzan , Aydin Zeki , Huddam Bulent , Dolarslan Murside Esra , Azak Alper , Bakırdogen Serkan , Yalcin Ahmet Uğur , Karadag Serhat , Ulu Memnune Sena , Gungor Ozkan , Ari Bakir Elif , Odabas Ali Rıza , Seyahi Nurhan , Yildiz Alaattin , Ates Kenan
Published: September 2022

Introduction: There are not enough data on the post-CO­VID-19 period for peritoneal dialysis (PD) patients affected from COVID-19. We aimed to compare the clinical and laboratory data of PD patients after COVID-19 with a control PD group. Methods: This study, supported by the Turkish Society of Nephrology, is a national, multicenter retrospective case-control study involving adult PD patients with confirmed COVID-19, using data collected from April 21, 2021, to June 11, 2021. A control PD group was also formed from each PD unit, from patients with similar characteristics but without COVID-19. Patients in the active period of COVID-19 were not included. Data at the end of the first month and within the first 90 days, as well as other outcomes, including mortality, were investigated. Results: A total of 223 patients (COVID-19 group: 113, control group: 110) from 27 centers were included. The duration of PD in both groups was similar (median [IQR]: 3.0 [1.88–6.0] years and 3.0 [2.0–5.6]), but the patient age in the COVID-19 group was lower than that in the control group (50 [IQR: 40–57] years and 56 [IQR: 46–64] years, p < 0.001). PD characteristics and baseline laboratory data were similar in both groups, except serum albumin and hemoglobin levels on day 28, which were significantly lower in the COVID-19 group. In the COVID-19 group, respiratory symptoms, rehospitalization, lower respiratory tract infection, change in PD modality, UF failure, and hypervolemia were significantly higher on the 28th day. There was no significant difference in laboratory parameters at day 90. Only 1 (0.9%) patient in the COVID-19 group died within 90 days. There was no death in the control group. Respiratory symptoms, malnutrition, and hypervolemia were significantly higher at day 90 in the COVID-19 group. Conclusion: Mortality in the first 90 days after COVID-19 in PD patients with COVID-19 was not different from the control PD group. However, some patients continued to experience significant problems, especially respiratory system symptoms, malnutrition, and hypervolemia.
Validation of the Remote Automated ki:e Speech Biomarker for Cognition in Mild Cognitive Impairment: Verification and Validation following DiME V3 Framework
Authors: Tröger Johannes , Baykara Ebru , Zhao Jian , ter Huurne Daphne , Possemis Nina , Mallick Elisa , Schäfer Simona , Schwed Louisa , Mina Mario , Linz Nicklas , Ramakers Inez , Ritchie Craig
Published: September 2022

Introduction: Progressive cognitive decline is the cardinal behavioral symptom in most dementia-causing diseases such as Alzheimer’s disease. While most well-established measures for cognition might not fit tomorrow’s decentralized remote clinical trials, digital cognitive assessments will gain importance. We present the evaluation of a novel digital speech biomarker for cognition (SB-C) following the Digital Medicine Society’s V3 framework: verification, analytical validation, and clinical validation. Methods: Evaluation was done in two independent clinical samples: the Dutch DeepSpA (N = 69 subjective cognitive impairment [SCI], N = 52 mild cognitive impairment [MCI], and N = 13 dementia) and the Scottish SPeAk datasets (N = 25, healthy controls). For validation, two anchor scores were used: the Mini-Mental State Examination (MMSE) and the Clinical Dementia Rating (CDR) scale. Results: Verification: The SB-C could be reliably extracted for both languages using an automatic speech processing pipeline. Analytical Validation: In both languages, the SB-C was strongly correlated with MMSE scores. Clinical Validation: The SB-C significantly differed between clinical groups (including MCI and dementia), was strongly correlated with the CDR, and could track the clinically meaningful decline. Conclusion: Our results suggest that the ki:e SB-C is an objective, scalable, and reliable indicator of cognitive decline, fit for purpose as a remote assessment in clinical early dementia trials.
Intravitreal Brolucizumab for Neovascular Age-Related Macular Degeneration in a Vitrectomized Eye
Authors: Maggio Emilia , Alfano Alessandro , Mete Maurizio , Pertile Grazia
Published: September 2022

The efficacy of intravitreal anti-VEGF may be reduced in vitrectomized eyes due to accelerated drug clearance. Given its longer durability, brolucizumab may represent a suitable therapeutic option. However, its efficacy in vitrectomized eyes remains to be explored. Herein, we describe the management of a macular neovascularization (MNV) in a vitrectomized eye with brolucizumab after unsuccessful treatment with other anti-VEGF. A 68-year-old male was treated with pars plana vitrectomy for epiretinal membrane in his left eye (LE) in 2018. After surgery, best corrected visual acuity (BCVA) improved to 20/20 with a remarkable reduction of metamorphopsia. After 3 years, the patient returned, presenting visual loss in the LE due to MNV. He was treated with intravitreal bevacizumab injections. However, after the loading phase, an increased lesion size and exudation with worsening BCVA were detected. Therefore, the treatment was switched to aflibercept. However, after three monthly intravitreal injections, further worsening was recorded. Treatment was then switched to brolucizumab. Anatomical and functional improvement was noticed 1 month after the first brolucizumab injection. Two additional injections were performed, and further improvement was recorded with BCVA recovery to 20/20. At the last follow-up visit 2 months after the third injection, no recurrence was detected. In conclusion, determining whether anti-VEGF injections are efficacious for vitrectomized eyes would be helpful for ophthalmologists managing such patients, as well as when considering pars plana vitrectomy in eyes at risk of MNV. In our case, brolucizumab was found to be effective after unsuccessful treatment with other anti-VEGF. Additional studies are required to evaluate the safety and efficacy of brolucizumab for MNV in vitrectomized eyes.
Hyperglycemia and Lactic Acidosis Associated with Linezolid Therapy in an Extremely Premature Infant
Authors: Asai Takafumi , Kakita Hiroki , Nakamura Nami , Asai Shimpei , Mori Mari , Takeshita Satoru , Ueda Hiroko , Mizuno Yuki , Tomita Akiko , Aoyama Mineyoshi , Yamada Yasumasa
Published: September 2022

The use of linezolid is relatively safe for all age categories, including premature infants. The case of an extremely premature infant with hyperglycemia and lactic acidosis associated with linezolid is reported. A 350-g male infant was born at 24 weeks by cesarean section. His Apgar scores were 1 and 1 at 1 and 5 min, respectively. On the day of life (DOL) 7, linezolid was started at a dose of 10 mg/kg/dose every 8 h for a catheter-related blood stream infection caused by methicillin-resistant coagulase-negative Staphylococci. After linezolid was given, serum lactate and glucose levels increased gradually. After discontinuation of linezolid on DOL 16, hyperglycemia and lactic acidosis improved immediately. In conclusion, a rare case of an extremely premature infant with hyperglycemia and lactic acidosis associated with linezolid was reported. It is crucial to monitor glucose levels along with lactate and pH levels during linezolid therapy.
Extracellular Vesicles in Acute Kidney Injury
Authors: Yavuz Hayrettin , Weder Max M. , Erdbrügger Uta
Published: September 2022

Extracellular vesicles (EVs) are promising novel cellular communicators and biomarkers in acute kidney injury (AKI). These submicron vesicles derive from all cell types along the urinary tract and reflect molecular processes of their parent cells and physiological and pathological conditions in AKI. Several EV protein and RNA biomarker candidates have been identified. They have shown to differentiate AKI etiology and pinpoint to disease mechanisms. In fact, EV research has opened up a new frontier of biomarker discovery since some less abundant biomarkers are concentrated in EVs, which makes them more easily detectable. EVs are also functional and are involved in intra-nephron communication. Tubular-interstitial communication is current focus in EV research in AKI as it can help to understand maladaptive processes in AKI. EVs are also promising therapeutic tools and have been shown to be regenerative in many different models of AKI. Rigorous studies are needed to validate these findings, and more sensitive EV detection and characterization tools need to be developed to dissect EV biology in renal disease and AKI.
Acute Onset of Dense Vitreous Hemorrhage Associated with Retinal Arterial Macroaneurysm on the Optic Disc
Authors: Sasajima Hirofumi , Zako Masahiro , Aoyagi Akari , Ueta Yoshiki , Suzuki Takafumi
Published: September 2022

We present a rare case of acute onset of dense vitreous hemorrhage (VH) associated with ruptured retinal arterial macroaneurysm (RAM) on the optic disc. A 63-year-old Japanese man had undergone phacoemulsification combined with pars plana vitrectomy (PPV) including internal limiting membrane peeling in the right eye for a macular hole approximately 1 year before presentation. His decimal best-corrected visual acuity (BCVA) in the right eye was stable at 0.8 with no recurrence of macular hole. He visited our hospital emergently prior to his regular postoperative visit for a sudden decrease in visual acuity in the right eye. Clinical examinations and imaging tests revealed dense VH in the right eye, and we could not observe the fundus. B-mode ultrasonography of the right eye showed dense VH without retinal detachment and a bulge on the optic disc. His BCVA decreased to hand movement in the right eye. He had no medical history of hypertension, diabetes, dyslipidemia, antithrombotics, or ocular inflammation in both eyes. Accordingly, we performed PPV on the right eye. During vitrectomy, we found a RAM on the optic disc with retinal hemorrhage on the nasal side. We carefully reviewed the preoperative color fundus photographs and noticed that RAM was not present on the optic disc at the time of his visit 4 months earlier. After surgery, his BCVA improved to 1.2, the color of the RAM on the optic disc changed to grayish yellow, and optical coherence tomography images showed a shrunken RAM. RAM on the optic disc could cause VH early after its onset.
Effectiveness of Transcranial Direct Current Stimulation in Chronic Daily Headaches: An Experimental Single Case Report with a Novel Protocol
Authors: Rahimi Mohammad Dawood , Zargani Hedieh , Nikkhah Karim
Published: September 2022

Chronic daily headaches are often refractory to prescribed or non-prescribed medications. Transcranial direct current stimulation (tDCS) is a new technological-based intervention with various modes of applicability. Therefore, we aimed to study the effectiveness of tDCS in an individual with symptoms of chronic daily headaches and the associated comorbidities like depression, anxiety, stress, and RLS or sleepiness, numbness, a sensation of fullness, or ringing in the ears. Based on DASS-21 and Epworth questionnaires, headache diary, and semi-structured interviews, we used repeated measures for assessing the symptoms such as frequency, duration, intensity, or severity of chronic daily headaches and associated comorbidities at baseline, after tDCS-intervention, and at a 12-month follow-up. The results showed that tDCS-intervention reduced the frequency, duration, intensity, or severity of chronic daily headaches and associated symptoms after tDCS-intervention and at a 12-month follow-up.