bluuebunny/crossref_metadata_2025 huggingface dataset:
Study of microalbuminuria in patients of rheumatoid arthritis and its correlation with erythrocyte sedimentation rate, C - reactive protein and rheumatoid factor
Authors: Gupta Poonam , Agarwal Dipesh , Chaurasia Ajeet Kumar , Gupta Arvind
Published: May 2020

Background: Subclinical renal dysfunction and microalbuminuria are common in rheumatoid arthritis patients particularly with long standing disease and with severe disease activity. Despite the degree of interest shown in detection of microalbuminuria and its prognostic implications, the determinants of elevated urinary albumin excretion have not been studied well. This study was done to assess the subclinical renal involvement in Rheumatoid Arthritis (RA) patients.Methods: This cross-sectional study involving 50 patients attending attending the out-patient departments of Swaroop Rani Nehru Hospital, MLN Medical College, Prayagraj, U.P diagnosed with RA by modified ACR criteria (2010).Results: The mean age of the cases was 41.96 years (SD 10.80), of them 74% were females and 26% were males. MA was found in 15 patients (30%), of them. In MA positive group, mean ESR was 69.46±27.14, and CRP positive patients were 13 (86%), RA Factor positive patients were 12 (80%) and as compared to 31.28±5.03, 11 (32%), 14 (40%) respectively in MA negative group (p <0.05 in all cases). Microalbuminuria was significantly correlated with ESR, CRP and RA factor (p value <0.05).Conclusions: Presence of microalbuminuria indicates severe disease activity and long-standing rheumatoid arthritis. Microalbuminuria was found to be significantly correlated with disease activity in rheumatoid arthritis as assessed by ESR, CRP, RA Factor and anti CCP.
Unmasking the diabetic population in pre-diabetic subset of population
Authors: Agrawal Naman , Jhavar Dharmendra , Choudhary Rupal
Published: May 2020

Background: Identification of individuals with a high risk of developing diabetes and early diagnosis of diabetes is essential in prevention and early treatment of diabetes. Effective lifestyle and pharmacologic interventions to delay development of diabetes in people with high risk have been established.Methods: This Prospective non-randomized interventional study was conducted in 100 Pre diabetic patients who came in OPD of MGM Medical College and MY Hospitals, Indore, MP, from December, 2017 to February, 2019.Results: OGTT after 1hour was more than160mg/dl and OGTT after 2 hour was more than140mg/dl was found in 40 patients that is 40% of patients. The mean OGTT at 1 hour at presentation was 189.60±28.89 mg/dl and after 6 weeks (first follow-up) was 150.90±14.29mg/dl. The difference was found to be statistically significant (p=0.001), showing a significantly lower OGTT at 1 hour after 6 weeks (first follow-up). The mean OGTT at 1 hour after 6 weeks (first follow-up) was 169.00±3.72 mg/dl and after 6 weeks (second follow-up) was 148.67±6.29 mg/dl. The difference was found to be statistically significant (p=0.001), showing a significantly lower OGTT at 1 hour after 6 weeks (second follow-up) in comparison to follow-up after 6 weeks (first follow-up).Conclusions: Patients who were labelled as pre-diabetic on the basis of FPG and PPPG may have underlying diabetes which will remain unmasked due to less sensitivity of these tests individually.
Effect of ART2 on the CD4 count and viral load during treatment of second line ART
Authors: Singh Narendra , Varma R. K. , Giri Richa , Varma Punit , Dwivedi Seema , Kumar Lalit
Published: May 2020

Background: AIDS first recognized in US summer of 1981 by the U.S. CDC reported. In 1983 HIV was isolated from a patient of lymphadenopathy. This study was for monitoring the change in CD4 count and viral load of PL HIV before and after one year of second line ART in the period of 2016 to 2018.Methods: Study was single centre hospital based and clinical continuous longitudinal, prospective and retrospective, observational at ART plus Centre, Kanpur K.P.S. Institute of Medicine (G.S.V.M. medical college Kanpur) included the all patients on ART1 attending in centre were screened for treatment failure based on clinical, immunological and virological criteria’s as decided by SACEP from 2016 to 2018.Results: CD4 count at the time of initiation that of second line ART, there is low CD4 count the mean value is 181.44±85.02 in total subject 118 but 12 month of second line ART 2 treatment mean value of CD4 count 413.01±168.70. After Z test  application  the  value is 13.316, p value 0.0001, MD 231.5, CI is 95%.Viral load value at time of start of second line  ART  mean value is 80683.85849±293449.2038, after 1 to 12 month of start  of  second line ART treatment mean value is 350.8559±128.1069, for this Z value is 2.972, p value 0.0033.Conclusions: Second line ART is most effective in treatment after failure with first line ART. CD 4 count increase and viral load decrease and clinical feature improve after treatment of ART 2.
Application of allergic rhinitis and its impact on asthma guidelines in terms of classification, risk factors, quality of life and co-morbidities in allergic rhinitis patients in Northern India
Authors: Agarwal Anmol Kumar , Sharma Rohit , Sharma Vinit
Published: May 2020

Background: Despite the high prevalence of allergic rhinitis, there are only few studies on application of ARIA (allergic rhinitis and its impact on asthma) guidelines.

Methods: It was a prospective study of 164 patients. Based on ARIA guidelines; patients were graded for severity, risk factors studied, co morbidities documented and quality of life assessed using rhinoconjunctivitis quality of life questionnaire (RQLQ).  

Results: A total of 164 cases were studied between the age group 10-72 years of which 56.1% were males. Most common trigger observed was dust (56.1%). Allergic conjunctivitis was most common co-morbidity associated. Using RQLQ it was observed that ARIA.

Conclusions: ARIA guidelines appropriately classify allergic rhinitis, determines risk factors and associated co-morbidities. RQLQ can be used to determine quality of life in allergic rhinitis.
New technologies implemented in the design of a low-emission combustion chamber of a gas-turbine unit
Authors: Fedorchenko D. G. , Tsybizov Yu. I. , Tyulkin D. D. , Vorotyntsev I. E. , Zherelov D. A. , Dulov A. S. , Smelov V. G. , Sotov A. V. , Agapovichev A. V.
Published: May 2020

Metallist-Samara JSC has developed a fundamentally new design of a unified double-circuit burner of a low-emission combustion chamber (LECC) of a ground-based gas turbine unit (GTU), adapted for manufacturing with the help of an innovative technology by selective laser melting (SLM) of metal powders using CAD models. Several batches of burners were made and control studies were carried out characterizing the quality of manufacturing according to the established procedure. Deficiencies inherent in the SLM process were discovered, the main of which are: raised roughness, in particular, of the fuel channels of the main and duty zones; microporosity, microalloying; microcracks; instability of flow characteristics; local non-sintering zones of the layers grown on the burner body. As a result of the analysis of the state of the manufactured burners, research and refinements, it was found that most of the identified shortcomings can be eliminated during further development of the modes and parameters of the technological process. Currently, difficult engineering problems associated with the implementation of additive manufacturing technologies have been overcome.
Control over maintaining accuracy of integrity of reference surfaces of spacecraft components in their joint functioning at various stages of design
Authors: Yelenev V. D. , Schuplyak Yu. P.
Published: May 2020

The paper deals with ensuring the accuracy of integrity of spacecraft components reference surfaces at various stages of design. It is shown that the main problem consists in the fact that the accuracy of integrity of the reference surfaces of the components making up the complex is maintained in the framework of the internal structure of a part. We propose a method of control over ensuring the accuracy of integrity of spacecraft components reference surfaces at various stages of design in the framework of their external structures. The method is implemented by introducing the coordinate system of the complex into the scheme of the complex of components that perform interrelated service functions. Concepts and definitions are introduced in the framework of the method that make possible formal representation of accuracy of integrity of the components reference surfaces in the form of a set of pairs of points the appropriate annotated dimensions are fixed on. Graphical interpretation of the method at the stages of development of technical requirements for the components is presented. An example of potential implementation of the method at the stage of design documentation development is given.
PERFIL ALIMENTAR E ESTADO NUTRICIONAL DE IDOSOS EM INSTITUIÇÕES DE LONGA PERMANÊNCIA
Authors: Alexandrino Eduardo Gauze , Marçal Danilo Francisco da Silva , Antunes Mateus Dias , Nishida Fernanda Shizue , Oliveira Daniel Vicentini de , Bennemann Rose Mari , Bertolini Sonia Maria Marques Gomes
Published: May 2020

O objetivo deste estudo foi investigar o perfil alimentar e estado nutricional de idosos de instituições de longa permanência. Trata-se de uma revisão sistemática da literatura com a coleta de dados realizada nos bancos de dados: SCIELO, LILACS e Google Acadêmico entre 2012-2015. O percentual de idosos desnutridos em instituições de longa permanência é maior do que os que vivem na comunidade e idosos institucionalizados consomem sódio e proteína acima do recomendado e cálcio abaixo das recomendações. As instituições privadas parecem ter mais recursos para organização alimentar. Idosos desnutridos tiveram déficits funcionais e cognitivos em diversas áreas do cotidiano. Verificou-se um quadro de fragilidade do idoso institucionalizado no Brasil reafirmando a necessidade de políticas públicas. Os idosos institucionalizados apresentam risco maior de desnutrição.
A pandemia COVID-19 e as repercussões à Atenção à Saúde do Idoso Brasileiro
Authors: Garcia Luan Augusto Alves , Santos Álvaro Da Silva
Published: May 2020

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IT governance impact on financial reporting quality using COBIT framework
Authors: Haouam Djemaa
Published: May 2020

The aim of this study is to demonstrate the impact of the application of information technology governance (COBIT) on the quality of financial reporting. To achieve the objectives of this study, we used the analytical descriptive approach to study the theoretical and practical studies in the subject with an extrapolation of the main results and presentation of them in order to increase the quality of the financial reports. The study found that there is a correlation between IT governance and the COBIT framework in its four dimensions on the quality of financial reporting. It has been shown that there is a positive relationship between these dimensions and the quality characteristics of financial reporting.

Keywords: IT governance (ITG), accounting information quality, corporate governance, quality of financial reporting, COBIT.
Value of Performing a Rasch Analysis on a Reliable and Valid Instrument—Case Study of the SA-SH
Authors: Areskoug-Josefsson Kristina , Rolander Bo
Published: May 2020

Background and Purpose

The aim of this study was to explore the potential added value of performing a Rasch analysis on a reliable and valid instrument employed in nursing research and educational interventions, using the Students' Attitudes toward Sexual Health (SA-SH) as an example.

Methods

This study was performed with a polytomous Rasch model.

Results

The Rasch analysis confirmed the reliability and validity of the SA-SH. Rasch analysis presented information about the item's individual response options and gave the opportunity to judge how well different answers alternated in an item. The Rasch analysis also provided information about the proportion of extremes and the possibility of excluding these.

Conclusions

The Rasch analysis provides added value regarding information that needs to be considered regarding choices of questionnaire literacy compared to item fit. The SA-SH is also valid and reliable when tested with Rasch analysis.
FEATURES OF ELEMENT COMPOSITION OF HAIR OF STUDENTS ARRIVING TO STUDY IN MOSCOW MEGAPOLIS FROM DIFFERENT REGIONS OF THE WORLD
Authors:   Peoples' Friendship University of Russia, Kirichuk A.A.
Published: May 2020

The purpose of this study was to study the elemental status of first-year students of the Russian University of Friendship of Peoples who arrived to study from various climatogeographic regions of the world. Studies have shown that first-year students who came to study from different climatogeographic regions of the world are characterized by significant differences in the elemental composition of hair. Students from Latin America are characterized by a relatively high level of toxic metals Al, As, Hg, Sn, and students from Africa stand out by the highest levels of Al, B, Cd, Fe, I, Mn, Ni, Pb, Si, Sn, V. students from Iran and Azerbaijan revealed the minimum value of Co, Cu, Fe, I, Mg, Mn, Sn, V among all the studied groups. It was established that there are significant differences in the content of Ca, K, Mg, Na, P in the hair of male students from different regions of the world. Male students from Africa were characterized by the lowest Ca and P content in their hair, and the highest Mg content. The lowest content of K and Na was found in students from the countries of the Near and Middle East.
THE INFLUENCE OF RHYTHMS OF THE HYDROMETEOROLOGICAL INDICES ON THE WATER-MINERAL HOMEOSTASIS IN HYPERTENSIVE DISEASE (HD)
Authors:   «Erebuni» Medical Center, Urgent Cardiology Department,, Gulyan A.K. , Babayan L.A. ,   Armenian Medical Institute, Arutyunyan Ts.G. ,   Armenian Medical Institute, Gasparyan N.A. ,   Armenian Medical Institute, Mikaelyan A.K. ,   Armenian Medical Institute, Grigoryan S.G. ,   Armenian Medical Institute
Published: May 2020

70 practically healthy subjects and 100 patients with hypertensive disease were united regimen of diet, sleep and wakefulness. Urine was collected with 4-hour portions during 3-5 days. Each specimen was analyzed for electrolytes (sodium, potassium, phosphorus, chlorine, calcium, magnesium) and trace elements (iron, copper, zinc, chromium, cadmium, vanadium). Rhythms parameters have been estimated by dispersion analysis for nonsinusoidal rhythms and by nonlinear least squares method for sinusoidal rhythms. In healthy subjects in 91% cases of 593 rhythmological investigations urinary excretion electrolytes and trace elements statistically significant rhythms were observed. Healthy subjects characterized with circadian rhythms and with definite value of mesor and amplitude within the confidence limit. Acrophases of rhythms were mostly individual. The data witness that in early stage of HD electrolytes and trace elements exeretion rhythms 22% were statistically nonsignificant. Among significant rhythms of electrolytes and trace elements excretion infradians prevail - 46%. Statistically significant rhythms of electrolytes and trace elements excretion were not revealed in most of patients in the late stage of HD. Among significant rhythms circadian prevail - 48%. The data witness that in HD the coefficient of correlation between the biorhythms and the rhythms of hydrometerological indices were statistically nonsignificant (for early stage - 37% and for late stage - 30%).
GENETIC PECULIARITIES OF MACRO AND TRACE ELEMENTS ACCUMULATION BY ROOTS OF CELERY (APIUM GRAVEOLENS L.) AND PARSNIP (PASTINACA SATIVA L.)
Authors:   Federal Scientific Center of Vegetable Production, Golubkina N.A. , Kharchenko V.A. ,   Federal Scientific Center of Vegetable Production, Moldovan A.I. ,   Federal Scientific Center of Vegetable Production, Zayachkovsky V.A. ,   Federal Scientific Center of Vegetable Production, Stepanov V.A. ,   Federal Scientific Center of Vegetable Production, Soldatenko A.V. ,   Federal Scientific Center of Vegetable Production
Published: May 2020

Celery and parsnip are highly valuable root vegetables and medical plants all over the world. Beneficial effect of plants on human health is connected not only with high content of biologically active compounds but also with specific levels of minerals reflecting geochemical characteristics of habitat, climate and genetic peculiarities. Using ICP-MS method comparative evaluation of 25 minerals content in roots of celery (Egor and Dobrinya cvs) and parsnip (Krugly, Bely Aist, Zhemchug cvs) was achieved. Similar high levels of all macro-elements except Na and Mg were demonstrated for these crops. Contrary to celery, parsnip contains 89 times lower concentrations of sodium and 1.6 time lower content of Mg. In identical environmental conditions celery significantly exceeds parsnip in accumulation of Fe (1.5 times), Mn (1.7 times). Cr (8.6 times), Se (6 times) and Sr (1.8 times). Consumption of 100 g fresh celery roots in human diet provides 48-61% of Cr daily requirement level, 17% of B, about 10% of Fe and 2030% of adequate consumption level. High levels of Sr in celery roots is beneficial for health of human bones but may be harmful in regions with elevated radioactive pollution.
BEHAVIOR OF ELEMENTS DURING HIGH-TEMPERATURE BONE COMBUSTION
Authors:   National Research Tomsk Polytechnic University, Deriglazova M.A. , Rikhvanov L.P. ,   National Research Tomsk Polytechnic University
Published: May 2020

The number of studies of ashed biosubstrates in terms of elemental composition is sharply increasing due to the growing interest of living matter. Thus, it is extremely important to know, is the composition of the ashed material reflects the composition of the original object and how elements behave during the process of combustion. To answer these questions, an experiment on the samples of biological material was made. The purpose of the study is to analyze the behavior of elements in the process of high-temperature combustion of bone tissue. During the experiment, the following methods of analysis were used: instrumental neutron activation and mass spectrometry with inductively coupled plasma. The study shows that most of the elements are concentrated in bone ash during combustion (Li, Na, Mg, P, Ca, Ti, Cu, Zn, Ga, U, Al, Sc, Cr, Mn, Fe, As, Y,, Zr , Nb, Mo, Cd, Sb, La, Ce, Pr, Sm, Gd, Au, W, Bi), while volatilization is observed only for Br, Hg and Sn. The exclusive role of the chemichal compound of the element is shown for the analysis of its behavior. The experiment is aslo shows the role of combustion temperature to predict the behavior of element: it was found that lower temperature of ashing (500 °C) leads to more intensive volatilization of elements. In addition, an algorithm is propesed to convert the content of the element in ash of the bone to dry matter. At the same time, the dependence of the content of elements in the ash on their content in dry tissue were established using mathematical functions with high accuracy of approximation (for Fe, Mg, Zn, As, Pr, Ce, W, Zr, Cd, Cr, Sb, Mn, Ga, Nb, Pb, and U).
Characteristic Temporary Loss of Taste and Olfactory Senses in SARS-CoV-2-positive-Individuals with Mild Symptoms
Authors: Schmithausen Ricarda Maria , Döhla Manuel , Schößler Heidrun , Diegmann Christin , Schulte Bianca , Richter Enrico , Eis-Hübinger Anna-Maria , Streeck Hendrik
Published: May 2020

SARS-CoV-2 infection has been characterized as an upper and lower respiratory tract infection with symptoms ranging from sore throat, cough, headache, and fatigue to a severe respiratory syndrome that requires intensive care [1-7]. Although a lower death rate has been recorded for SARS-CoV-2 in comparison to other recent coronavirus outbreaks, such as MERS or SARS, a compromised respiratory status on admission has been associated with fatal outcomes. Among the >1200 SARS-CoV-2-infected individuals in Germany to date, many of the diagnosed persons show mild symptoms to no clinical signs of infection. Here we describe the onset and characteristics of symptoms in a cluster outbreak after a carnival celebration in a small town in the state of North Rhine-Westphalia currently contributing 43% of the total number of infected individuals in Germany to date [8]. Among the nearly 500 individuals in domestic quarantine as ordered by the Local Health Authority at that time, we interviewed 41 randomly selected individuals with qPCR confirmed SARS-CoV-2 infection. Inclusion criteria for the survey participation were: residents, positive for SARS-CoV-2 in pharyngeal swabs, ≥18 years of age, and confirmed informed consent. Median age was 40 years (IQR: 31-53, range: 18-82) and 51% were female. All persons examined had attended a carnival festivity also attended by the SARS-CoV-2positive index patient. All persons who attended this carnival festivity were tested for SARS-CoV-2 by the local health authorities 10 days later. Among survey participants, onset of symptoms began 12 days (IQR: 11-13) after probable infection and a median of 6 distinct symptoms (IQR: 4-8) were described.
AWARENESS ANALYSIS OF INDUSTRY 4.0
Authors: YILMAZ Kevser , ÖZDAĞOĞLU Aşkın
Published: May 2020

Industry 4.0 is a new disruptive (r)evolution that not only affects the production systems of companies but also affects the society as a whole. This new revolution brings several new benefits to firms, such as; a more flexible production system, individual production, digital value chain, new business models, resource, and energy efficiency. Therefore, it is very important for firms to be aware of the Industry 4.0. In this study, the Industry 4.0 awareness of the firms located in İzmir and Manisa is investigated. Moreover, a chi-square analysis is conducted in order to determine the relationship between firm size and awareness of Industry 4.0’s terms and R&D budget of firms and awareness of Industry 4.0’s terms.
NESTORIUS, CYRILL VE PULCHERIA ÜÇGENİNDE MARYOLOJİ VE NASTURİLİĞİN DOĞUŞU
Authors: DURMAZ Sayime , GÖKBAYIR Satılmış
Published: May 2020

Meryem’in tabiatı üzerine V. asrın ilk çeyreğinde başlayan Maryoloji tartışmaları Hristiyanlıktaki ikinci büyük ayrışma olan Nasturiliğin doğuşuna sebep olmuştur. Meryem’in Tanrı’nın Annesi mi (Theotokos) yoksa Mesih’in Annesi mi (Kristotokos) olduğu yönündeki tartışmalar her ne kadar teoloji ve kristoloji temelli görünse de arka planda Kilise merkezleri arasındaki siyasal çatışmaların olduğu bilinmektedir. Bu tartışmaların neticesinde düzenlenen I. Efes Konsili’nde Konstantinopolis Patriği Nestorius’un “diyofizit” görüşü mahkûm edilmiştir. Bu çalışmada Hristiyanlıkta Meryem Kültü’nün beslendiği kaynaklar, Meryem Kültü’nün oluşmasına yol açan teolojik ve kristolojik tartışmalar, tartışmaların arka planında bulunan Antakya Kilisesi, İskenderiye Kilisesi ve Konstantinopolis Sarayı arasındaki siyasal çatışmalar ve bunların sonucu olarak 431’de Efes’te toplanan üçüncü ekümenik konsil incelenmiştir.
ENDÜSTRİ 4.0 ÇAĞINDA ÖĞRENCİ GÖZÜYLE ÖĞRETMENİN GEREKLİLİĞİ VE ROLÜ
Authors: YARIM Mehmet Ali , ÇELİK Sabri
Published: May 2020

Bu çalışmada öğrencilerin günümüz öğretmenlerinin nitelik ve rollerine ilişkin görüşleri incelenmiştir. Nitel araştırma yöntemlerden biri olan durum çalışması tekniği kullanılan bu çalışma Erzurum il merkezinde öğrenim görmekte olan 19 gönüllü lise öğrencisinin katılımı ile gerçekleştirilmiştir. Veri toplama aracı olarak, araştırmacıların geliştirdiği dört soruluk görüşme formu kullanılmıştır. Veriler nitel analiz yöntemlerinden içerik analizi ve betimsel analiz yoluyla analiz edilmiştir. Araştırma sonucunda öğrencilerin günlük hayatta kullandıkları bilgilere en çok internet (web siteleri, bloglar, arama motorları, eğitim siteleri v.b.) ve sanal alemden (twiter, instagram, facebook v.b.) ulaştıkları, günümüz öğretmenlerini, öğrenme süreçlerinde genellikle düz anlatım ve ezbere dayalı metodlar kullanıp sadece öğrencilerde bilgi birimi sağladıkları, dersleri sadece ders saatleri ile sınırlı olmak kaydıyla müfredata bağlı kalarak tek düze işledikleri ve değerlendirmeleri yönlendirme yerine sınıflandırma amacıyla yapmaları gibi gerekçelerle yeterli nitelikte görmedikleri, öğretmenlerden bekledikleri yeni rollerin ve niteliklerin; kolaylaştırıcı, destekleyici, yaşam koçu, rol model, özgürleştirici, terapist ve arkadaş olma rolleri ile adaletli olma, uyumlu ve ilgili, eleştiriye açık, sürekli gelişen ve öğrencileri geliştirme, teknolojiyi bilen ve derslerde bilişim teknolojilerinin unsurlarını kullanma nitelikleri olduğu sonuçlarına ulaşılmıştır.
SAĞLIK BİLİMLERİ FAKÜLTESİ ÖĞRENCİLERİNİN E-SAĞLIK OKURYAZARLIĞI DÜZEYLERİNİN BELİRLENMESİ
Authors: YILMAZ Ali , SAYGILI Meltem , KAYA Mustafa
Published: May 2020

Bu çalışma, Sağlık Bilimleri Fakültesi öğrencilerinin e-sağlık okuryazarlığı düzeylerini belirlemek ve öğrencilerin demografik özelliklerinin e-sağlık okuryazarlığı üzerinde etkili olup olmadığını ortaya koymak amacıyla yapılmıştır. Çalışmanın evrenini Kırıkkale Üniversitesi Sağlık Bilimleri Fakültesi’nde 2016-2017 yılında eğitim gören öğrenciler oluşturmaktadır (N=1621). Öğrencilerin e-sağlık okuryazarlığı düzeylerini belirlemek için Norman ve Skinner (2006a) tarafından geliştirilen ve Coşkun ve Bebiş (2015) tarafından Türkçe geçerlik-güvenirlik çalışması yapılan “E-Sağlık Okuryazarlığı Ölçeği (e-HEALS:The e-Health Literacy Scale)” kullanılmıştır. Öğrencilerin e-sağlık okuryazarlığı düzeylerinin orta ve yüksek seviyede olduğu (ortalama 29,48) belirlenmiştir. Sağlık Bilimleri Fakültesi öğrencilerinin e-sağlık okuryazarlığı düzeylerinin iyileştirilmesi konusunda çalışmalar yapılması önerilmektedir.
KADIN TURİST REHBERLERİNİN MESLEKİ SORUNLARININ BELİRLENMESİ
Authors: KÖROĞLU Özlem , ULUSOY YILDIRIM Hasret , KILIÇ Arzu
Published: May 2020

Bu çalışmanın amacı kadın turist rehberlerinin meslekte karşılaştıkları sorunları belirlemek ve sorunların giderilmesi noktasında çözüm önerileri sunmaktır. Söz konusu amaç doğrultusunda araştırmada nitel araştırma yöntemlerinden kasti örnekleme yöntemi tercih edilmiş, yarı yapılandırılmış bir soru formu oluşturulmuştur. Araştırmada elde edilen verilerin belirli kategoriler altında toplandığı tespit edilmiştir. Kadın turist rehberlerinin mesleki sorunları turistler, seyahat acentaları, sektör çalışanları, turun gerçekleşmesinde görev alan elemanlar, mesleğin yapısı ve kadının doğası gereği yaşadığı sorunlar olarak altı grupta toplanmıştır. Araştırma sonuçlarına göre kadın turist rehberleri en çok tur şoförleriyle sorun yaşamaktadır. Araştırmaya katılan kadın turist rehberlerinin mesleki sorunlarına yönelik çözüm önerileri noktasında en fazla eğitim konusuna değinildiği tespit edilmiştir. Alanyazın taraması ve elde edilen sonuçlar ışığında öneriler sunulmuştur.
DUYGUSAL ZEKÂ ÇATIŞMA YÖNETİM STRATEJİLERİNİ NASIL ETKİLEMEKTEDİR?: ÇALIŞAN ALGISINA YÖNELİK BİR ARAŞTIRMA
Authors: ÇETİNEL Gamze , ESEN Emel
Published: May 2020

Finansal hizmetler sektöründe yapılmış olan bu çalışmanın temel amacı; firma yöneticilerinin duygusal zekâ düzeylerininin uyguladıkları çatışma yönetimi stratejileri üzerindeki etkisini çalışan algısına dayanarak incelemektir. Bu doğrultuda, 150 çalışanlı finansal hizmetler sektöründe faaliyet gösteren bir firmanın 106 kadrolu çalışanına bir anket uygulanmıştır. Çıkan sonuçlara göre, çalışan algısına yönelik olarak yöneticilerin duygusal zekâlarının uyguladıkları çatışma yönetimi stratejileri ile etkileşimde olduğu ve özellikle “kişisel yetenekler ve iletişim becerileri” duygusâl zekâ boyutunun çatışma yönetimi stratejilerini etkilediği görülmüştür. Araştırma kapsamında, duygusal zekâsı yüksek yöneticilerin “bütünleştirme ve işbirliği” ile “kaçınma” stratejilerine başvurma oranlarının arttığı, “ödün verme” ile “hükmetme” stratejilerine başvuru düzeylerinde ise azalış olduğu ortaya konmuştur.
TÜRKİYE’DE İLLER BAZINDA SEKTÖREL ELEKTRİK TÜKETİMİ VE EKONOMİK BÜYÜME İLİŞKİSİ: PANEL ARDL SINIR TESTİ YAKLAŞIMI
Authors: ÇADIRCI Bülent Diclehan , GÜNER Bilal
Published: May 2020

Ülkelerin ekonomik gelişmişlik göstergelerinin bir sonucu olarak artan elektrik tüketimi; araştırmacı ve politika yapıcıların, elektrik tüketiminin ekonomik büyüme üzerine katkısını incelemelerine sebep olmuştur. Bu çalışmanın amacı, Türkiye’nin 81 ilinin sektörel elektrik tüketim verileri ile illerin ekonomik büyüme ilişkisini ortaya koymaktır. Bu doğrultuda 2004-2016 dönemi için, 81 ilin resmi daire, sanayi, ticarethane, mesken ve diğer (tarımsal sulama, sokak aydınlatması vb.) sektörlerdeki elektrik kullanımı ile illerin ekonomik büyümesi arasındaki ilişki, Panel ARDL Sınır Testi kullanılarak analiz edilmiştir. Analiz sonuçlarına göre, uzun dönemde ticarethane ve meskenlerde kullanılan elektrik ile o illin reel GSYH‘sı arasında anlamlı ve pozitif bir ilişki bulunmuştur. Kısa dönemde ise tüm sektörlerin elektrik tüketiminin, pozitif ve anlamlı katsayılara sahip olduğu sonucuna ulaşılmıştır. Hem uzun hem de kısa dönemde, illerin reel GSYH değerlerini en çok etkileyen değişkenin meskenlerde tüketilen elektrik olduğu görülmektedir. Kısa dönem analiz sonuçları her il için ayrı ayrı incelendiğinde, sadece 21 ilde hata düzeltme katsayısının anlamlı sonuç verdiği görülmektedir.
The Implementation of Think Pair Share (TPS) Learning Model toward Student Achievement Learning in Material Acid and Base in Grade XI MA Sunan Pandanaran Academic Year 2018/2019
Authors: Rahmah Nafisa , Merdekawati Krisna , Diniaty Artina
Published: May 2020

The purpose of this study was to determine the significant difference in student achievement learning through the implementation of a think pair share (TPS) learning model and conventional learning model on acid-base material. This research is an experimental study using quasi-experimental design, namely posttest only with nonequivalent group design. The study population was all students of class XI MA Sunan Pandanaran Yogyakarta academic year 2018/2019. The sample in this study was taken by purposive sampling technique as many as two classes. Data collection using the written test method with instruments in the form of multiple-choice questions to obtain data on learning achievement. Data analysis techniques in this study used Mann Whitney Test. Based on the results of the study it can be concluded that there are significant differences in learning achievement between students who take part in the TPS learning model and students who take the conventional model learning on acid-base material.
ELASTISITAS HARGA TERHADAP PENAWARAN OUTPUT DAN PERMINTAAN INPUT USAHATANI JAGUNG DI KABUPATEN GROBOGAN, JAWA TENGAH
Authors: Sahara Dewi , Suhendrata Tota
Published: May 2020

Permintaan jagung cenderung meningkat, namun harganya juga relatif berfluktuasi. Penelitian ini bertujuan untuk mengetahui pengaruh perubahan harga output dan harga input terhadap penawaran jagung dan permintaan input produksi. Kegiatan dilaksanakan pada bulan September – Nopember 2016 dengan metode survey terhadap 30 petani jagung di Desa Boloh, Kecamatan Toroh, Kabupaten Grobogan.  Data yang dikumpulkan meliputi data karakteristik rumah tangga, jumlah dan harga input, jumlah dan harga jagung. Data dianalisis dalam bentuk pangsa biaya menggunakan metode Seemingly Unrelated Regression (SUR). Hasil penelitian menunjukkan bahwa penawaran output terhadap harga sendiri bersifat elastis dengan tanda positif, sedangkan terhadap harga input bertanda negatif dan bersifat inelastis, kecuali terhadap permintaan pupuk Urea.  Elastisitas permintaan input terhadap harga sendiri bertanda negatif dan inelastis kecuali terhadap permintaan pupuk Urea dan tenaga kerja bersifat elastis, sedangkan terhadap harga input lainnya besaran dan tandanya bervariasi.  Luas areal tanam bersifat inelastis terhadap permintaan input produksi. Demikian pula dengan pendidikan dan pengalaman usahatani bersifat inelastis kecuali terhadap permintaan tenaga kerja bersifat elastis. Oleh karena itu untuk meningkatkan produksi jagung dapat dilakukan dengan meningkatkan harga jagung, memperluas areal tanam dan meningkatkan kapabilitas sumberdaya petani.
Jejunal inflammatory cytokines, barrier proteins and microbiome-metabolome responses to early supplementary feeding of Bamei suckling piglets
Authors: Jipeng Jin , Jia Jianlei , Zhang Liping , Chen Qian , Zhang Xiaoyan , Sun Weibo , Ma Cunming , Xu Fafang , Zhan Shoujun , Ma Limin , Zhou Guihua , Chen Qiaoxi
Published: May 2020

Background: Dietary intervention has been reported to improve intestinal health. The intestinal microbiota of newborn animals plays a fundamental role in the development of intestinal function and the innate immune system. However, little is currently known about dietary interventions in the gut microbiota and barrier function of livestock, especially suckling Bamei piglets. To this end, we studied the effect of early dietary supplementation on intestinal bacterial communities and intestinal barrier function in piglets.Results: 10 purebred Bamei sows were randomly allocated into two groups. In group one, the piglets received a supplementary milk replacer on day 7 of age, whereas the other control group was allowed sow’s milk alone. At 21 days, 18 and 17, respectively, piglets in each group of average weight were randomly selected and sacrificed. Tissue and digesta samples were collected from the jejunum to evaluate differences in the microbiome-metabolome and the mRNA expression of inflammatory cytokines (TLR4, TNFα and IL-8) and barrier proteins (ZO-1, Occludin and Claudin-1). Sequencing of 16S rRNA revealed that ES improved the gut microbiome composition of Bamei suckling piglets. The relative abundances of some bacterial species such as Lactobacillales, Romboutsia, Actinobacillus, Bacteroides were significantly reduced in the ES group. Metabolomics analysis indicated that 23 compounds were enriched and 35 compounds decreased in the ES group. And correlation analysis demonstrated that some gut bacterial genera were highly correlated with altered gut microbiota-related metabolites. Meanwhile, ES of Bamei suckling piglets altered the gene expression of inflammatory cytokine and barrier protein in the jejunum. Conclusions: In summary, these results provide important insights on the relationships between jejunal microbiota and related metabolites, and jejunal barrier function during the early life of Bamei suckling piglets.
Inhibition of lipogenesis and induction of apoptosis by valproic acid in prostate cancer cells via the C/EBPα/SREBP-1 pathway
Authors: Pang Bo , Zhang Juanjuan , Yuan Jihong , Shi Yanan , Qiao Ling
Published: May 2020

Background: Lipid metabolism reprogramming is now accepted as a new hallmark of cancer. Hence, targeting the lipogenesis pathway may be a potential avenue for cancer treatment. Valproic acid (VPA) emerges as a promising drug for cancer therapy, however, the underlying mechanisms are not yet fully understood. This study aimed to investigate the effects and mechanisms of VPA on cell viability, lipogenesis, and apoptosis in human prostate cancer PC-3 cells.Methods: The effects of VPA on the viability of PC-3 cells were investigated using MTT cell viability assay and wound-healing assay. Oil-Red O staining was used to examine lipid droplets, and DAPI staining assay and Annexin V-FITC and PI double-staining assay were used to measure the extent of cell apoptosis. Quantitative real-time PCR and Western blotting were used to determine the expression of lipogenesis and apoptosis genes. Statistical and analytical data were analyzed with SPSS 17.0 Software, and statistical significance was set to *P < 0.05, **P < 0.01, and ***P < 0.001 levels.Results: The results showed that VPA significantly reduced lipid accumulation and induced apoptosis of PC-3 cells. Moreover, the expression of CCAAT/enhancer-binding protein α (C/EBPα), as well as sterol regulatory element binding protein 1 (SREBP-1) and its downstream effectors, including fatty acid synthase (FASN), acetyl CoA carboxylase 1 (ACC1), and antiapoptotic B cell lymphoma 2 (Bcl-2), markedly decreased in PC-3 cells after VPA administration. Mechanistically, the overexpression of C/EBPα rescued the levels of SREBP-1, FASN, ACC1, and Bcl-2, enhanced lipid accumulation and attenuated apoptosis of VPA-treated PC-3 cells. Conversely, knockdown of C/EBPα by siRNA further decreased lipid accumulation, enhanced apoptosis, and reduced the levels of SREBP-1, FASN, ACC1, and Bcl-2. In addition, SREBP-1a and 1c enhanced the expression of FASN and ACC1, but only SREBP-1a had a signiﬁcant eﬀect on Bcl-2 expression in VPA-treated PC-3 cells.Conclusions: On the whole, it is concluded that VPA significantly inhibits cell viability via decreasing lipogenesis and inducing apoptosis via the C/EBPα/SREBP-1 pathway in PC-3 cells. Therefore VPA which targets lipid metabolism and apoptosis is a promising candidate for prostate cancer chemotherapy.
WITHDRAWN: Grassland utilization estimation method and system based on environmental sense
Authors: Wang Chuanjian , Li Dong , Yan Tianying , Wang Qilei , Wang Ju , Bing Wanlong
Published: May 2020

The utilization of natural grassland is an important part of grazing animal husbandry. Effective monitoring and accurate estimation of the utilization of natural grassland are inevitable requirements for the sustainable development of grazing animal husbandry. In order to estimate the utilization process of natural grassland effectively, this paper proposes a grassland utilization estimation method based on environmental sense. In this paper, the distribution of feed intake was obtained by the GPS trajectory data, and the distribution of grassland biomass was obtained by the satellite remote sensing estimation model of natural grassland. The feed intake and grassland biomass are classified and compared respectively. According to the value of the two, the utilization of grassland in each region was obtained. And this study designed a grassland utilization estimating system based on this estimating method and 3S technology. The results show that this method is of great significance to the rational utilization of grassland and the implementation of rotational grazing. The system can provide decision-making basis for ranchers and grassland livestock management departments to manage grazing and grassland. It enables ranchers to make reasonable and effective grazing plans, so as to make balanced utilization of grassland resources and promote the sustainable development of grazing animal husbandry.
Cox-maze III Procedure for Atrial Fibrillation during Valve Surgery: A Single Institution Experience
Authors: Wang Changtian , Zhang Lei , Qin Tao , Xi Zhi-long , Sun Lei , Wu Hai-wei , Li De-min
Published: May 2020

Objectives: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in patients with heart valve disease. Our aim was to summarize our experience and evaluate the efficacy and safety of the Cox maze III procedure combined with valve surgery in patients with AF. Methods: A retrospective, observational analysis was performed for all consecutive patients underwent maze III procedure combined with valve surgery between October 2015 and June 2019. In this trial, we used a monopolar radiofrequency (RF) ablation in addition to cut and sew technique to treat AF.Results: 66 patients (37 female, 56.1%) with persistent or long-lasting persistent AF associated with valve disease were identified. The mean age was 54.2±8.4 years (range, 30 to 73 years). Overall hospital mortality was 3.0%. The duration of cardiopulmonary bypass and aortic cross clamping was 175.4±32.9 and 115.6±22.8 minutes respectively. The first 24hours drainage was 488.6±293.3ml. The postoperative hospital stay was 14.8±8.3 days. The postoperative incidence of permanent pacemaker implantation, reoperation for bleeding, renal failure required hemodialysis, and stroke was 4.5%, 1.5%, 4.5% and 0 respectively. The frequency of sinus rhythm was 91.7%, 93.1%, 94.7%, 93.3% and 89.5% at 1, 3, 6, 12, and 24 months respectively.Conclusions: The Cox-Maze III procedure is safe in the surgical treatment of AF associated with valve disease, and efficacious for sinus rhythm maintenance, with low morbidity and mortality.
“Apple does not fall far from the tree” – subclinical atherosclerosis in children with familial hypercholesterolemia.
Authors: Podgórski Michał , Szatko Katarzyna , Stańczyk Małgorzata , Pawlak-Bratkowska Monika , Konopka Agnieszka , Starostecka Ewa , Tkaczyk Marcin , Góreczny Sebastian , Rutkowska Lena , Gach Agnieszka , Łukaszewski Maciej , Grzelak Piotr , Banach Maciej
Published: May 2020

Background: Familial hypercholesterolemia (FH) increases the risk of atherosclerosis in children and adults. Atherosclerotic cardiovascular disease in young patients FH is usually subclinical but recognition of children with more pronounced changes is crucial for adjusting effective management. Aim of this research was to use ultrasonography with two-dimensional speckle tracking (2DST) and tonometry to evaluate atherosclerotic changes in patients with FH (parents and their offspring).Methods: Applanation tonometry and carotid arteries sonography with evaluation of the intima-media complex thickness (IMCT) and application of the 2DST were performed in 20 families with FH (20 parents and 29 children). The same size control group (age and sex matched) was included. Results were compared between peers and between generations together with the correlation analysis.Results: Adults with FH, in comparison with healthy peers, presented significantly more atherosclerotic plaques (9 vs. 2, p=0.0230), had significantly thicker IMC (0.84±0.19 vs. 0.56±0.06 mm, p<0.0001) and had stiffer arterial wall (for stain: 6.25±2.3 vs. 8.15±2.46, p=0.0103). In children from both groups there were no atherosclerotic plaques and IMCT did not differ significantly (0.42±0.07 vs. 0.39±0.04, p=0.1722). However, children with FH had significantly stiffer arterial wall according to 2DST (for strain: 9.22±3.4 vs. 11.93±3.11, p=0.0057) and tonometry (for the pulse wave velocity: 4.5±0.64 vs.3.96±0.62, p=0.0047). These parameters correlated with atherosclerosis surrogates in their parents (p<0.001) but were not significantly affected by presence of presumed pathogenic gene variant.Conclusions: Children with FH presented subclinical atherosclerosis manifested as decreased arterial wall elasticity. Degree of stiffening was associated with advancement of atherosclerosis in their parents but did not present significant association with gene variants. Sonography with application of 2DST seems to be a good candidate for comprehensive evaluation of atherosclerosis in families with FH.
The impact of immunotherapy on the survival of pancreatic adenocarcinoma patients who received definitive surgery of the pancreatic tumor: A retrospective analysis of the National Cancer Database
Authors: Amin Saber , Baine Michael , Meza Jane , Alam Morshed , Lin Chi
Published: May 2020

Background: Immunotherapy has paved the way for new therapeutic opportunities in cancer but has failed to show any efficacy in Pancreatic Adenocarcinoma (PDAC), and its therapeutic role remains unclear. The objective of this study is to examine the impact of immunotherapy in combination with chemotherapy, RT, and chemoradiation on the overall survival (OS) of PDAC patients who received definitive surgery of the tumor using the National Cancer Database (NCDB). Methods: Patients with PDAC who received definitive surgery of the pancreatic tumor and were diagnosed between 2004 and 2016 from the NCDB were identified. Cox proportional hazard analysis was used to assess the survival difference between patients who received chemotherapy plus immunotherapy and chemoradiation therapy plus immunotherapy and their counterparts who only receive these treatments without immunotherapy. The multivariable analysis was adjusted for age of diagnosis, race, sex, place of living, income, education, treatment facility type, insurance status, year of diagnosis, and treatment types such as chemotherapy and radiation therapy. Results: In total, 63,154 PDAC patients who received definitive surgery of the tumor were included in the analysis. Among the 63,154 patients, 636 (1.01%) received immunotherapy. Among patients who received chemotherapy (21,355), and chemoradiation (21,875), 157/21,355 (0.74%) received chemotherapy plus immunotherapy, and 451/21,875 (2.06%) received chemoradiation plus immunotherapy. Patients who received chemoradiation plus immunotherapy had significantly improved median OS compared to patients who only received chemoradiation with an absolute median OS benefit of 5.7 [29.31 vs. 23.66; p <0.0001] months. In the multivariable analysis, patients who received immunotherapy had significantly improved OS compared to patients who did not receive immunotherapy (HR: 0.90; CI: 0.81-0.99; P <0.039). Patients who received chemoradiation plus immunotherapy had significantly improved OS compared to their counterparts who only received chemoradiation without immunotherapy (HR: 0.85 CI: 0.75-0.95; P <0.008). Conclusions: In this study, the addition of immunotherapy to chemoradiation therapy was associated with significantly improved OS in PDAC patients who received definitive surgery. The study warrants further future clinical trials of immunotherapy in PDAC.
Peritumoral ductular reaction can be a prognostic factor for intrahepatic cholangiocellular carcinoma
Authors: Shen Zhenyang , Xiao Jingbo , Wang Junjun , Lu Lungen , Wan Xinjian , Cai Xiaobo
Published: May 2020

Background
Peritumoral ductular reaction (DR) was reported to be related to the prognosis of combined hepatocellular-cholangiocarcinoma and hepatocellular carcinoma. Non-mucin-producing intrahepatic cholangiocellular carcinoma (ICC), may be derived from small bile duct cells or liver progenitor cells (LPCs). However, whether peritumoral DR is also related to non-mucin-producing ICCs needs to be investigated.
Methods
Forty-seven patients with non-mucin-producing ICC were eventually included in the study. Clinicopathological variables were collected. Immunohistochemical analysis and immunofluorescence staining for cytokeratin 19, proliferating cell nuclear antigen, and α-smooth muscle actin were performed in tumor and peritumor liver tissues.
Results
Peritumoral DR is significantly correlated with local inflammation and fibrosis. Patients with significant peritumoral DR had high recurrence rate (81.8% vs 56.0%, P = 0.058) and poor overall and disease-free survival time (P = 0.01 and P = 0.03, respectively). Significant peritumoral DR showed high proliferation activity of LPC/cholangiocytes and abundant background extracellular matrix.
Conclusions
Patients with non-mucin-producing ICC having significant peritumoral DR had a poor prognosis. Peritumoral DR could be a prognostic factor for ICC; however, the mechanism should be further investigated.