bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhancing partnership performance of medical clinics in Java, Indonesia: Perspective of women’s managerial roles
Authors: Apriza Sari , Achmad Kuncoro Engkos , Alamsjah Firdaus , Furinto Asnan
Published: September 2024

This study aims to determine the role of women with managerial positions in medical clinics and the ways in which they can enhance the performance of their partnerships to optimize business opportunities within the healthcare services sector of Indonesia. The study identified two key challenges: complex requirements from corporate partners and limited partnership capabilities of female employees. The study used entrepreneurial marketing theory as a framework to identify the key factors that can improve partnership performance by strengthening the capabilities of women in these roles. The study gathered data from 113 health clinics in Java, Indonesia, where female managers were responsible for marketing, partnerships, and director roles. The data were analyzed using structural equation modeling. The results reveal a positive impact of intrapreneurship and partnership capabilities on partnership performance. It is noteworthy that relationship quality exerts no influence on partnership performance. Furthermore, relationship quality does not function as a mediating variable for intrapreneurship capability or partnership capability on partnership performance. The healthcare services ecosystem attenuates the relationship between relationship quality and partnership performance. Additionally, the prevalence of medical clinics with female managers in the healthcare services ecosystem significantly affects partnership performance in the Java region, Indonesia.
Synthesis and Characterization of Double Calcium Iron Phosphate from Chicken Eggshell
Authors: S. Gomes Luiz Claudio , Braga Rhayra , P. Aguiar Diego , R. Andrade Leonardo , S. Cavalcanti Amanda , V. Colaço Marcos , M. Guimarães João Antonio , F. Lima Juliana
Published: September 2024

With the increase in life expectancy and the significant incidence of lesions of the musculoskeletal system, both the public and private sectors seek improvements in their products and processes in order to contribute to the health of the population. Every year tons of chicken eggshell (CES) from domestic consumption are released in environment and the present work aims the production of a synthetic ceramic bone substitute using the eggshell as a source of calcium ions. According to the methodology, 5, 10, 15 and 20 mol% of iron ions were used and the characterization assays demonstrated the formation of a double calcium iron phosphate - Ca9Fe(PO4)7. MG63 cells were cultured on test specimens to cell viability assay and to each doped group analyzed, verifying cell compatibility with the studied compounds, as well as a good adhesion profile. Scanning electron microscopy (SEM) of the cells showed that material surface favored cell adhesion and the results demonstrated that the production of the compounds were viable to Ca9Fe(PO4)7 phase. So, in the future, it will be possible to have a final comprehensive biological compatibility of the prototype for further in vitro and in vivo assays.
Application of modal analysis to multi-objective optimization of gear box
Authors: Zhang Sen
Published: September 2024

The high stiffness and low mass gearbox structure design requirements were met through multi-objective optimization based on finite element modal analysis. The correlation between structural parameters and optimization objectives was identified, providing guidance for optimal design. A parametric finite element model of the box cover was established to calculate the first-order modal shape and equivalent stiffness. By using mass and equivalent stiffness as optimization objectives, a discrete data set was constructed with key dimensions of the box cover as design variables, from which a surrogate model was obtained. Standard response surface and full second-order polynomial fitted response surface function were applied after error verification. Different optimization algorithms were employed to search for the optimal value, resulting in obtaining design variables meeting the optimization objectives. The results indicated a reduction in optimized mass by approximately 6.8 %, with an error of less than 1 %.
Numerical analysis of the influence of air flow channel on ear pressure during door closure
Authors: Ren Lei , Zhang Tao , Tang Yongwei , Cai Zhou , Zhou Jianwen , Chen Jingchang
Published: September 2024

In this paper, Numerical simulation analysis was conducted on the ear pressure of a certain vehicle model during door closing process. Firstly, relevant airflow channel parameters are formulated based on the benchmark vehicle data, and transient closing ear pressure simulation calculation is carried out using overset grid technology. Then, the impact of key structural parameters on the interior ear pressure of the car was analyzed. Finally, based on the requirements of actual engineering design, the design scheme for the peak pressure of the car was determined, and the results will be a reference for the development and design of later vehicle.
Assessment of the impact of TE33A diesel locomotive wheelsets on the railway track in a straight section of the track
Authors: Abdullayev Seidulla , Bakyt Gabit , Abdullayeva Asel , Toktamyssova Aliya , Sarsanbekov Kurmangazy , Bektilevov Aldabergen
Published: September 2024

The purpose of the article is an experimental study of the impact of the wheelsets of a mainline diesel locomotive on the railway track on straight sections of the track. The measurements were performed on a vibration measuring device consisting of MV25 DV type sensors and an oscillation converter for a digital signal. It is proved that the indicators of dynamic characteristics comply with regulatory requirements. As a result of the conducted research, digital data was collected from the ADC and general monitoring was carried out. Measurement and signal processing are carried out using special software of a personal computer such as a “Notebook”. Vertical static load of a wheelset of a railway rolling stock unit on rails: the load of a railway rolling stock unit on rails attributed to one wheelset, taking into account the actual location of the center of gravity of the superstructure.
Modal characteristics analysis of agricultural vehicle support frame
Authors: Shi Xiao
Published: September 2024

The support frame of large agricultural vehicles was simulated using the finite element method to ensure stability and reliability. Modal experiments were conducted to verify the simulation accuracy, and mesh division and optimization were performed based on different size and structure types. Three types of loads were applied according to different working conditions. The natural frequency, vibration mode, stress, and deformation characteristics of the model under prestressed mode condition were calculated to determine the weak structure of the support frame. Modal measurement points for calibration during test modal analysis were used to generate a test modal model with force hammer, acceleration sensor, signal acquisition instrument, and other devices. The results showed that there was good agreement between finite element modal analysis and experimental modal analysis with a maximum error in natural frequency of 2.2 %, verifying the accuracy of the finite element model.
Prestressed modal and fatigue characteristic analysis of pedal machine support
Authors: Sun Yu , Li Qianru , Liu Jinkun
Published: September 2024

To ensure the reliability and stability of the pedal machine support under prolonged operational conditions, prestressed modal analysis and fatigue characteristic analysis were conducted using the finite element method. A coupling module integrating intensity and mode was constructed and imported into Workbench via intermediate data files to facilitate grid division, material property definition, and load application. Through simulation and calculation, the first four natural frequencies and modes of the model were determined, aligning with vibration response test results. The stress field analysis showed that the maximum stress experienced by the model was 93 MPa, meeting static strength requirements. Furthermore, fatigue life and safety factor of the support frame were assessed under fatigue analysis conditions. The conclusions indicate that the structure exhibits robust safety characteristics in compliance with fatigue load requirements.
Statistical review of literature sources on carbon emissions during the CSPB based on knowledge graphs
Authors: Yao Gang , Li Rui , Yang Yang , Cai Xiaodong , Zhou Yan , Ma Xinlong , Wang Dawu , Qu Hao
Published: September 2024

The construction industry, a significant contributor to global carbon emissions, is pivotal in implementing carbon reduction strategies. This study delves into the carbon emissions associated with the construction stage of prefabricated buildings (CSPB), a burgeoning field of research. Utilizing the CiteSpace knowledge graph visualization software, we comprehensively analyzed literature from the Web of Science (WoS) database. Our study encompasses several vital dimensions: academic paper publication volume, keyword co-occurrence network, keyword co-occurrence network clustering, and citation burst visualization and analysis. The findings indicate that the topic of carbon emissions in prefabricated building construction is gaining increasing attention globally. Over the past decade, related literature has surged by an average annual growth rate of 41.42 %. Key research themes have emerged around the quantification of carbon emissions, construction methodologies, influencing factors, mitigation strategies, the use of prefabricated components, and predictive studies on emissions. These insights underscore the evolving focus and critical importance of this field in global sustainability efforts.
Method of experimental determination of the effective area of a pneumatic spring of high-speed rolling stock
Authors: Kuzyshyn Andrii , Kovalchuk Vitalii , Kravets Ivan , Korendiy Vitaliy , Royko Yuriy
Published: September 2024

The object of research is a pneumatic spring of high-speed rolling stock of the railway. The method of experimental static testing of a pneumatic spring of high-speed rolling stock is presented. Based on experimental tests, the “force-strain” dependences of a pneumatic spring are obtained when the pressure gauge in the pneumatic spring changes from 2.5 atm up to 5.0 atm. Using a thermodynamic model, a quadratic equation is found to determine the effective area of a pneumatic spring. It is established that when the pressure gauge in the pneumatic spring changes from 2.5 atm up to 5.0 atm the effective area of the pneumatic spring varies from 0.231 m2 to 0.306 m2. The scientific novelty lies in the fact that for the first time, on the basis of static experiments, the change in the effective area of the pneumatic spring of high-speed rolling stock depending on the value of the gauge pressure in the spring was established. This will make it possible to determine the forces acting on the pneumatic spring in different operating conditions, ensuring the required level of safety of rolling stock.
Vibration technology to produce highly active hydrated lime
Authors: Yakymechko Yaroslav , Borovets Zenon , Lutsyuk Iryna , Solohub Bohdan , Danylo Yaroslav
Published: September 2024

This paper proposes a mechanical dispersion method of hydrated lime in a vibrating activator equipped with special blades that operate in a resonant mode. It has been found that during the vibro-activation process, hydrated lime consistently passes through proportionately increasing stages of dynamic viscosity, slowing its growth and ceasing dispersion. A new vibration method for determining the viscosity of the hydrated lime-water system has been developed. The effect of vibration treatment on changes in the dispersion of calcium hydroxide was studied. It has been found that vibration-treated lime, compared to conventional hydrated lime, has new properties: the ability to form durable coatings due to accelerated carbonization.
Effect of welding axial stresses on the strength of a welded pipe joint with a defect
Authors: Dzyubyk Andriy , Dzyubyk Liudmyla , Soloviov Oleh
Published: September 2024

The use of an integrated approach to determining the static strength of operated main pipelines with surface defects makes it possible to take into account the effect of residual weld stresses in combination with operational loads. In this case, it is important to determine the nature of the welding stress distribution for welded structures made of high-strength steels. Here, there is non-uniformity of stresses concerning magnitude and gradient, which is due to technological methods. A mathematical model of the experimental-calculation method is proposed. Such a model allows describing such stresses. A two-parameter criterion for brittle-tough fracture of a material which takes into account the influence of residual stresses is used. It is shown that the combination of residual stresses and operating loads has a significant effect on the safety factor. At the same time, conditions are possible under which compressive residual stresses have a favourable effect on the static strength of a pipeline with a defect.
Gas parameter characteristics in Reflux Flotation Cell
Authors: Gao Bo , Li Jianguo , Yuan Xue , Chen Peng
Published: September 2024

Flotation is a primary method for separating fine particles, and the growing demand for processing these particles has driven recent research efforts towards developing and designing more efficient flotation devices. Among these, the Reflux Flotation Cell (RFC) stands out as an innovative solution specifically tailored for fine particle flotation. Gas parameters are crucial factors influencing flotation and are essential indicators for evaluating flotation equipment. This study primarily investigates the gas characteristics within the RFC, including bubble size, gas holdup, and bubble surface area flux. The experimental results indicate that bubble diameters range from 0.4 to 0.8 mm, gas holdup ranges from 30 % to 50 %, and bubble surface area flux ranges from 120 to 400 s-1. These findings demonstrate that the RFC provides an optimal gas environment, conducive to effective mineral flotation.
An improved wavelet threshold function denoising method based on IGA optimization
Authors: Zhang Mengqi , Ma Haitao , Wu Yifan , Cui Weibo
Published: September 2024

In single crystal diamond tool grinding, cutting-edge quality is affected by various parameters, with tool vibration playing a crucial role. Due to environmental factors and the complexity of the process, vibration signals are often noisy and non-stationary. This study proposes a denoising method that optimizes the wavelet threshold function using an Improved Genetic Algorithm (IGA). The method introduces a configurable value α in the wavelet threshold function, which is optimized with IGA to improve denoising. MATLAB R2018b simulations show that this approach achieves better denoising, a higher signal-to-noise ratio, and lower mean square error.
A Zhu-Wang-Tang damage constitutive model for sintered NdFeB considering crack spacing
Authors: Yao Yuwei , Yang Guolai , Li Lei , Wang Liqun
Published: September 2024

Currently, research on the dynamic damage characteristics of sintered NdFeB is still in its early stages. Previous dynamic mechanical experiments on sintered NdFeB have shown that it is a strain rate-sensitive material. So, it is necessary to establish an appropriate damage constitutive model to describe the dynamic mechanical behavior of sintered NdFeB, with the aim of expanding its practical application range. This paper first establishes a damage evolution model by combining the Weibull distribution with a wing crack propagation model that considers crack spacing. Then, the damage model is integrated with the Zhu-Wang-Tang (ZWT) constitutive model to create the ZWT damage constitutive model. The model is fitted against previous experimental data to determine the specific parameters. Finally, to verify the accuracy of the newly established damage constitutive model, it is compared with the damage constitutive model proposed by Li. The comparison results fully affirmed the accuracy of the newly established ZWT damage constitutive model.
Stakeholder perceptions, challenges, and sustainable solutions for achieving safely managed sanitation in Kazakhstan: a case study from a cold region
Authors: Uteyeva Aiman , Lee Woojin , Templeton Michael R.
Published: September 2024

In this paper, we present survey results from 30 sanitation stakeholders across the public and private sectors, professional associations, non-governmental organisations (NGOs), and households in the two coldest cities of Kazakhstan. The objectives were to identify the perceived sanitation challenges, document innovative, and traditional solutions employed by the stakeholders to manage sanitation challenges during the cold season, and to propose initiatives and policy interventions to alleviate pressing sanitation issues. Commonly encountered problems included improper installation of septic tanks (e.g. above the frost line) by non-professionals and the difficulty of households to access latrines during heavy snowfall events. Ninety-three percent of respondents expressed that foul odours and sewage overflows were their primary concerns, with only 7% reporting health impacts as a primary concern. There were significant differences in the viewpoints of the respondents regarding the extent of sanitation infrastructure maintenance or upgrades needed in the two cities, suggesting regional differences across the country rather than a uniform national situation. In the context of Kazakhstan, local NGOs were identified as playing a key role in engaging with households to co-devise affordable and sustainable sanitation solutions that are suitable for cold regions, which can then be communicated to other sanitation stakeholders, including the public sector.
Risk factors associated with Helicobacter pylori infection among patients attending private clinics in Borama district, Somaliland
Authors: Yusuf Abdirashiid Saleban , Adebisi Sunday Adesina , Osiri Josiah Odongo
Published: September 2024

Risk factors associated with Helicobacter pylori infection among patients attending private clinics in Borama district, Somaliland, are studied. We specifically investigated the association among the use of non-steroidal anti-inflammatory drugs, the users’ socioeconomic status, and the household hygiene practice of people with H. pylori infection attending the Borama private clinic. Helicobacter pylorus (H. pylori) is a Gram-negative spiral-shaped bacterium that infects gastric-type epithelium, and it is probably the most common bacterial agent in humans after Streptococcus mutans, which causes dental caries. H. pylori infection is now recognized as a worldwide problem and it is the most common cause of chronic gastritis and is strongly linked to peptic ulcer disease and gastric cancer. The prevalence of H. pylori infection is high in less-developed Asian countries like India, Bangladesh, Pakistan, and Thailand, and is acquired at an earlier age than in the more developed Asian countries like Japan and China. H. pylori infection is a global public health problem, affecting over 50% of the population worldwide.
Exploring the Potential Effects and Mechanism of Astragalus Membranaceus in Treating Ischemic Heart Failure Based on Network Pharmacology
and Experimental Verification
Authors: Xing Chaoqun , Xing Xiao-Liang , Luo Hai , Huang Minjiang , Zhang Xuemei , Yao Zhiyong
Published: September 2024

Background:

Astragalus membranaceus (AM) is a traditional Chinese medicine that
has been clinically utilized as an adjunctive therapy for the treatment of myocardial ischemia and
heart failure; however, its precise molecular mechanism of action remains unknown.

Objective:

This study aims to investigate the potential pharmacological effects and molecular
mechanism of AM in the treatment of ischemic heart failure (IHF) using network pharmacology
methods, molecular docking technology, and in vitro experiments.

Methods:

The active components and targets of AM were obtained from the TCMSP databases,
while the disease targets of IHF were retrieved from GeneCards and OMIM databases. The
analysis of overlapping targets between AM and IHF mainly included active compounds-targets
network, PPI network, and GO and KEGG enrichment analysis. The association between active
compounds and target proteins was verified through molecular docking. Additionally, an in vitro
experimental model was used to evaluate the accuracy of the forecast results.

Results:

The network pharmacological analysis revealed that quercetin, kaempferol, 7-Omethylisomucronulatol,
formononetin, and isorhamnetin were the core active components of
AM in treating IHF. The core targets included AKT1, IL6, IL1B, PTGS2, CASP3, MMP9, and
HIF1A. The molecular docking results demonstrated a strong binding affinity between these active
components and targets. The KEGG pathway analysis suggested that the PI3K-AKT signaling
pathway might play a central role in mediating AM's therapeutic effects on IHF. In vitro experiments
demonstrated that AM treatment enhanced cell viability, reduced heart failure biomarkers,
and suppressed cell apoptosis. Furthermore, the western blot analyses indicated that
AM treatment effectively regulated AKT1 phosphorylation in an experimental model of IHF.

Conclusion:

Through integrated network pharmacological analysis, molecular docking technology,
and in vitro experimental validation, it was demonstrated that AM can effectively mitigate
IHF through activating PI3K-AKT signaling pathway. These findings significantly advance our
understanding of the molecular mechanisms in IHF treatment and contribute further to promoting
the clinical application of AM.

other:

none
Necrotizing Enterocolitis: A Current Understanding and Challenges for the Future
Authors: De Bernardo Giuseppe , Vecchione Carolina , Langella Carmen , Ziello Carla , Parisi Grazia , Giordano Maurizio , Buonocore Giuseppe , Perrone Serafina
Published: September 2024

This perspective reviews the definition and current understanding of necrotizing enterocolitis
and evaluates a future prevention approach to this multifactorial disease. An overview of
the prevention approach in general is presented, where key aspects and emerging criticisms are
identified. In addition, key elements of early diagnosis and treatment are presented, together with
some of their challenges and ambiguities. Moreover, it concludes with emerging questions from
the global community to reach a consensus on the definition, diagnosis, and management of necrotizing
enterocolitis disease.
Formulation and Characterization of Pomegranate-beetroot Gummies: A Healthy Confectionary Approach
Authors: Malik Manisha , Dewan Aastha , Arya Devrat , Singh Ajay , Kumar Krishan , Luthra Ankur
Published: September 2024

Purpose/Objective:

Gummies are a popular confectionary product, especially among
children, and keeping in view, improvisation in its nutritional and sensorial characteristics is the
need of the hour.

Methodology:

For this purpose, juices of pomegranate and beetroot were incorporated using different
proportions. Six formulations were studied in which the ratio of pomegranate to beetroot
juices was 60:40, 70:30, 80:20, 40:60, 30:70, and 20:80. Physicochemical characteristics such as
moisture, ash, pH, total soluble solids (TSS), total phenolic content (TPC) and antioxidant activity
(DPPH) and, overall acceptability, color (L, a and b values), textural and microbiological characteristics
of gummies were studied to select appropriate formulation.

Results:

Highest TPC (0.19 mgGAE/g), antioxidant activities (84.1 mg/100g), sensory acceptability
(8) and resilience (92.7) were observed in sample having highest proportion of pomegranate
juice (80:20) and moisture (18%), ash (0.08%), pH (3.915), and TSS (73.2 °Brix) of this formulation
were within the specified range as stated for gummies.

Conclusion:

Thus, gummies prepared with 80% pomegranate juice and 20% beetroot juice may
serve as delicious healthy confectionary without addition of synthetic color and flavor.
Design and Synthesis of (2,3-dichloro-4-(3-(substituted Phenyl)acryloyl) phenoxy) Substituted Carboxylic Acid as Potent Glutathione-s-transferase
Inhibitors, Anti-breast-cancer Agents and Enhancing Therapeutic Efficacy of Anticancer Agents
Authors: Qayyum Afreen Begum A. , Ali Syed Ayaz , Mokale Santosh N.
Published: September 2024

Background:

Ethacrynic acid is a dynamic agent holding alpha-beta unsaturated carbonyl
unit in its structure which imparts superiority and extraordinary advantage of displaying multiple
biological activities such as anticancer, antiviral, anti-malarial effect, diuretic effect and inhibits the
Glutathione-s-transferase p1-1 enzyme which produces hindrance in the pathway of apoptosis. Ethacrynic
acid is an inhibitor of Glutathione-s-transferases. EtA by itself act as an anti-cancer agent at
higher concentration and also increases effectiveness of other compounds used in cancer treatment
by preventing their detoxification, all these facts attracted our attention to develop and evaluate
novel structural analogues of ethacrynic acid for their inhibitory effect on GSTs and anti-cancer
activity in breast cancer.

Objective:

By attending rational drug design perspectives the research is aimed to develop and
evaluate novel structural analogues of ethacrynic acid as Inhibitors of GSTs enzyme and with antibreast
cancer activity.

objective:

By attending rational drug design perspectives the present research study is focused on development and evaluation of novel structural analogues of ethacrynic acid as Inhibitors of Glutathione-s-transferase enzyme and anti-breast cancer agents.

Methods:

Designed compounds were synthesized as per convenient route shown in the scheme of
synthesis. Molecular docking studies were done against GSTP1-1 (PDB:3HJO). Structures of novel
synthesized molecules were confirmed by spectral characterization such as FTIR, 1HNMR,
13CNMR and Mass spectrometry. ADME studies were done to ensure safety and drug like properties
of the compounds. Ten structural analogues of ethacrynic acid were synthesized and evaluated
for their inhibitory effect on activity of Glutathione-s-transferases which was measured by performing
assay (Habig et al) method. In-vitro anti-breast cancer activity was done on MCF-7 and
MDAMB-231 cell line by MTT assay.

Results:

Compound A3, A5 and A6 were found with greater inhibition of the activity of GSTs and
maximum anti-proliferative activity in breast cancer.

Conclusion:

We have effectively developed novel compounds possessing structural resemblance
with ethacrynic acid Compounds of the series has shown moderate to higher inhibitory effect on
GSTs and anti-proliferative activity in breast cancer. The compound A3 was found to be promising
agent with high level of potency in each biological response. The research studies presented here
may be an enlightening path in development of novel therapeutic agents with high level of inhibition
in the activity of GSTs and anti-breast cancer effect.
Novel Design for Multi-Epitope Vaccines of COVID-19 and Critical In-Silico Assessment Steps
Authors: Lan Tian , Su Shuquan , Ping Pengyao , Li Jinyan
Published: September 2024

Introduction:

The coronavirus disease COVID-19, caused by the SARS-CoV-2 virus,
was a global pandemic that happened in March of 2020. The virus was mutated into several widelyspread
strains such as Alpha, Beta, Gamma, Delta, and Omicron, and is continuing its unpredictable
mutation.

Method:

Multi-Epitope Vaccine (MEV) is one type of recombinant vaccine with its sequence containing
multiple epitopes and is considered as an effective way to fight against the infectious disease.
Previous in-silico approaches to MEV construction have been constrained by their inability to
predict molecular conformation structures accurately, consequently leading to inaccurate property
evaluations. In this work, we designed a novel MEV for the future prevention of COVID-19 or
similar diseases. We set strict thresholds to screen for epitope candidates in order to construct highly
effective MEV and use the latest ColabFold (a modified version of AlphaFold2) to predict accurate
tertiary structures of the MEV.

Results:

We especially studied epitopes from the main proteins of SARS-CoV-2 (i.e., the envelope,
membrane, nucleo-, and spike proteins) that can provoke immunity response of B-cells, helper Tcells
(Th), and cytotoxic T-cells (CTL), then we combined them through amino acid linkers to construct
the MEV. We evaluated the vaccine in terms of its physicochemical properties, population
coverage, safety for use, secondary and tertiary structure, docking immunity response, and immu
nity response eliciting capability.

Conclusion:

These in-silico assessments demonstrate that our proposed vaccine can elicit effective
immune responses and it is safe to use with a high population coverage.
A Significant Prospective on Nanorobotics in Precision Medicine and Therapeutic Interventions
Authors: Soni Sakshi , Purohit Arpana , Nema Priyanshu , Rawal Rashmi , Kumar Ajay , Soni Vandana , Kashaw Sushil K.
Published: September 2024

Nanorobotics, situated at the intersection of nanotechnology and robotics, holds the potential
for revolutionary impact on precision medicine and medical interventions. This review explores
the design, navigation, drug delivery, and applications of nanorobots. Architectural intricacies,
sensor integration, and navigation strategies, both active and passive, are discussed.
Nanorobots are poised to play a pivotal role in controlled drug delivery and personalized
medicine, including disease-specific targeting. Their applications span across various domains, including
cancer therapy, neurological interventions, and emerging fields. Despite the promises,
challenges such as technological hurdles, regulatory considerations, and safety concerns are also
acknowledged. The review anticipates a transformative impact on healthcare, offering a comprehensive
guide for researchers, clinicians, and policymakers navigating the evolving landscape of
nanorobotics.
PERBEDAAN SPESIFIK MORFOLOGI Dysmicoccus neobrevipes DENGAN KUTU PUTIH LAINNYA PADA KOMODITAS PISANG
Authors: Widyantoro Arief , Athoriyah Badiatul
Published: September 2024

Dysmicoccus neobrevipes dari famili Pseudococcidae merupakan hama penting dengan distribusi luas di Indonesia. Serangan hama kutu putih secara ekonomi dapat merusak komoditas pisang asal Maluku Utara. Keberadaan kutu putih di pertanaman sangat beragam dan melimpah. Kutu putih dapat menimbulkan gejala kerusakan pada seluruh bagian tanaman terutama pada buah. Tujuan penelitian adalah mempelajari karakteristik morfologi D. neobrevipes dengan kutu putih jenis lain pada komoditas pisang. Sampel spesimen diambil secara purposive sampling di lima pasar sentra pisang meliputi pasar Bastiong (Pulau Ternate), pasar Jailolo (Halmahera Barat), pasar Tobelo (Halmahera Utara), pasar Labuha (Pulau Bacan), dan Pasar Sanana (Kepulauan Sula). Preparasi spesimen dan identifikasi menggunakan metode Heinz yang dimodifikasi. Variabel pengamatan morfologi berupa bentuk tubuh dan keberadaan organ spesifik kutu putih. Hasil menunjukkan D. neobrevipes berbentuk oval, mempunyai 17 cerarri, sepasang antena, 2–3 discoidal pore, anterior ostiole dan posterior ostiole berkembang baik, 2–4 conical seta, 3–7 auxilary seta, sekelompok trilocular pore, circulus berkembang sempurna, terdapat translucent pore pada tibia dan femur tungkai belakang, oral coral tubular duct bertipe besar dan kecil, dorsal seta lebih pendek dari anal ring seta, multicolar pore terdapat di tengah, anal ring terdiri 6 seta dan anal cerarri terdiri 2 conical seta.
AI-Supported Digital Microscopy Diagnostics in Primary Health Care Laboratories: Protocol for a Scoping Review
Authors: von Bahr Joar , Diwan Vinod , Mårtensson Andreas , Linder Nina , Lundin Johan
Published: September 2024

Background

Digital microscopy combined with artificial intelligence (AI) is increasingly being implemented in health care, predominantly in advanced laboratory settings. However, AI-supported digital microscopy could be especially advantageous in primary health care settings, since such methods could improve access to diagnostics via automation and lead to a decreased need for experts on site. To our knowledge, no scoping or systematic review had been published on the use of AI-supported digital microscopy within primary health care laboratories when this scoping review was initiated. A scoping review can guide future research by providing insights to help navigate the challenges of implementing these novel methods in primary health care laboratories.

Objective

The objective of this scoping review is to map peer-reviewed studies on AI-supported digital microscopy in primary health care laboratories to generate an overview of the subject.

Methods

A systematic search of the databases PubMed, Web of Science, Embase, and IEEE will be conducted. Only peer-reviewed articles in English will be considered, and no limit on publication year will be applied. The concept inclusion criteria in the scoping review include studies that have applied AI-supported digital microscopy with the aim of achieving a diagnosis on the subject level. In addition, the studies must have been performed in the context of primary health care laboratories, as defined by the criteria of not having a pathologist on site and using simple sample preparations. The study selection and data extraction will be performed by 2 independent researchers, and in the case of disagreements, a third researcher will be involved. The results will be presented in a table developed by the researchers, including information on investigated diseases, sample collection, preparation and digitization, AI model used, and results. Furthermore, the results will be described narratively to provide an overview of the studies included. The proposed methodology is in accordance with the JBI methodology for scoping reviews.

Results

The scoping review was initiated in January 2023, and a protocol was published in the Open Science Framework in January 2024. The protocol was completed in March 2024, and the systematic search will be performed after the protocol has been peer reviewed. The scoping review is expected to be finalized by the end of 2024.

Conclusions

A systematic review of studies on AI-supported digital microscopy in primary health care laboratories is anticipated to identify the diseases where these novel methods could be advantageous, along with the shared challenges encountered and approaches taken to address them.

International Registered Report Identifier (IRRID)

PRR1-10.2196/58149
Quantifying Patient Demand for Orthopedics Care by Region through Google Trends Analysis: Descriptive Epidemiology Study  (Preprint)
Authors: Qiu Abram , Meadows Kristopher , Ye Fei , Iyawe Osasu , Kenneth-Nwosa Kenneth
Published: September 2024

BACKGROUND

There is a growing gap between surgeon availability and demand for orthopedic services in the United States. This study analyzes the geographic trends of this gap with a Relative Demand Index to guide precision public health interventions such as resource allocation, residency program expansion, and workforce planning to specific regions.

OBJECTIVE

Regional disparities in access to orthopedic care can be addressed with increasing orthopedic residencies based on our findings. We used publicly available online data to correlate the supply of orthopedic surgeons and demand for them across the United States.

METHODS

Data is from the US Census Bureau, AAMC ERAS directory, AAMC State Physician Workforce Data Report, and Google Trends. We calculated a normalized Relative Search Volume (RSV) and Relative Demand Index (RDI) and analyzed their relationship to the densities of orthopedic surgeons across the United States. We examined disparities with Spearman's rank correlation coefficient.

RESULTS

Orthopedic surgeon density, normalized to the highest density in our data, varies across the country, with the highest densities in Alaska (n=100), the District of Columbia (n=96), and Wyoming (n=72), and the lowest in Texas (n=0), Arkansas (n=6), and Oklahoma (n=64). States with the highest RDI values are Utah (n=97), Florida (n=88), and Texas (n=83), while those with the lowest are Alaska (n=0), the District of Columbia (n=5), and New Hampshire (n=7). Seven states lack orthopedic surgery residencies: Alaska, Maine, South Dakota, Wyoming, Montana, Delaware, and Idaho. In 2023, New York (n=19), Michigan (n=17), Ohio (n=17), Pennsylvania (n=16), and California (n=16) had the most residency programs.

CONCLUSIONS

This study highlights the novel application of RDI to map regional need for orthopedics, and with this map, allow for better targeted resource allocation to expand orthopedic surgery training. The availability of orthopedic surgeons varies significantly across the US, with higher demand in southern states. Demand and supply, which RDI and orthopedic surgeon density represent, respectively, are strongly correlated negatively (r=-0.791, P<.001). States with more than fifteen residency programs still have a high demand (r=0.455, P<.001) for orthopedic surgeons.
Cognitive-Behavioral Play Therapy for Preschool Children with Anxiety Disorder Symptoms Related to Moral and Religion: A Single Case Study
Authors: Harwiningtyas Annisa Nur , Yuniarti Kwartarini Wahyu
Published: September 2024

Anxiety disorder in children requires attention due to its comorbidity with depression. Proper management of this condition is essential. This single case study research explored the effectiveness of cognitive-behavioral play therapy in treating a 6-year-old girl attending an Islamic school who exhibited symptoms of religious anxiety. The client attended a total of 8 intervention sessions. The assessment process involved interviews, observations, and psychological tests, including CPM, Bender-Gestalt, and SCARED for Parents. Pre- and post-intervention results, measured using the SCARED for Parents and unstructured interviews, indicated a reduction in anxiety symptoms, improved coping mechanisms, and changes in maladaptive thinking.
GAMBARAN STRES KERJA PERAWAT INSTALASI GAWAT DARURAT DI RUMAH SAKIT WILAYAH SLEMAN
Authors: Tiyani Nazhifah Salsabila
Published: September 2024

Background: The Emergency Department (ED) is the entrance to every service in the hospital that is on duty for 24 hours and serves to provide the first service to patients. Emergency department nurses are vulnerable to job stress due to the dynamic and unpredictable work environment. Job stress can also come from work-related stressors, individual characteristics, and extra organizational stressors. There has not been much research on work stress among emergency room nurses at Yogyakarta hospital.
Objective: To determine the description of work stress of emergency room nurses in Sleman area hospitals based on the characteristics of respondents.
Method: The type of research used was descriptive analytic research with cross sectional design. The population in this study were 122 nurses who worked in four emergency departments of Sleman hospitals. The sampling technique used total sampling. Data collection used Juniar (2005) instrument modified by Jusnimar (2012). Data were analyzed using Chi-square.
Results: The results showed that the overall work stress of emergency room nurses was at a moderate level (63,1%). There was a significant difference in the average work stress of nurses in the emergency room of RSA UGM with RS PKU Muhammadiyah Gamping (p=0,003 <0.05). Based on characteristics of respondents, the Chi-square test results of nurses' work stress based on age, gender, educational status, marital status, length of work and clinical nurse ladder were p=0,654; p=0,471; p=0,894; p=0,67; p=0,608; p=0,958; respectively.
Conclusion: The work stress of nurses working in the emergency room is at a moderate level. The description of the stress experienced by emergency room nurses is an input for policy makers in determining strategies or policies to reduce the work stress of emergency room nurses.
Keywords: Emergency room; nurse; work stress.
Becoming, Rheology and Deterritorialization : on Sensibility Illustration in The White Peacock from the Affect Theory
Authors: Xiaomeng Lin
Published: September 2024

The White Peacock by D.H. Lawrence in the Victorian era distinguishes itself with delieantion in affect, different from other works with bold strokes of sexual love. The factors and the change of identity in affective entanglements between Lettie, George and Leslie reflect the great emphasis of the emotion involved in love on the representation of the subject. The dynamics of affect is pivotal in delineating the interplay between the self and the other, the rhizomatic “becoming” subjectivity, and the rheology within the narrative. This paper explicates the exerted power of affect as the change of intensity of life, the becoming to new identities attributed to affect, and the deterritorializaton and rheology in Lettie’s subjectivity by drawing upon Gilles Deleuze’s critique of affect theory by Spinoza. The examination of Lettie’s marital and romantic choices under this perspective insinuates the vicissitudes of Victorian women's vitality amidst the complexities of love, the ideological nomadism of female subjects, and their emancipation from the entrenched frameworks of subjectivity. The inescapable outcome of their life trajectories and innate capacity for treating different affect movement. Although the affective power leads to the hybridity and contradiction of her action, her subjective consciousness and desire of self-confirmation against regulated, traditional love ethics are elucidated. This paper shed lights on the analytical lens from the empowerment of the affect on the subjectivity, that experiences of life energetic flow vary across diverse contexts, reflecting the multifaceted nature of subjectivity.
Золотое лезвие секиры
Authors: Гринёв А.А.
Published: September 2024

История компании SEKIRUS отсчитывает уже 20‑летний возраст.
Но как производитель лазерного оборудования для обработки
листового и трубного металла и некоторых неметаллов под брендом
SEKIRUS компания вошла в число российских производителей
современного ЧПУ оборудования в 2019 году. А в 2023 году получила
статус высокотехнологичной компании. Производственные
мощности SEKIRUS находятся в России и в Китае. По приглашению
генерального директора компании SEKIRUS Андрея Александровича
Гринёва редакция журнала ФОТОНИКА побывала в июле месяце на
производственных площадках компании.
Форум ТИБО состоялся в 30-й раз
Authors: Попов С.А.
Published: September 2024

XXX Международный форум по информационно-коммуникационным технологиям с выставкой ТИБО-2024, организованный в начале июня в Минске Министерством связи и информатизации Республики Беларусь при участии широкого круга других государственных органов и компаний, стал событием, значение которого выходит за национальные рамки. Как и в прошлом году, в выставке в рамках ТИБО-2024 приняло участие немалое число компаний и вузов сферы ИКТ из Российской Федерации.
Транспортные ВОСП большой пропускной способности. Часть 2. Эволюция когерентных цифровых сигнальных процессоров. Окончание
Authors: Коган С.С.
Published: September 2024

В цикле статей представлены международные отраслевые стандарты для открытых линейных интерфейсов 400G со сменными когерентными оптическими модулями-приемопередатчиками (трансиверами) транспортных волоконно-оптических систем передачи (ВОСП) OTN/DWDM (часть 1), эволюция поколений когерентных цифровых сигнальных процессоров (ЦСП) для высокоскоростных оптических каналов (длин волн) ВОСП (часть 2), а также эволюция технологий, используемых для изготовления когерентных ЦСП для ВОСП (часть 3).
Имитационное моделирование услуги передачи данных мультисервисной сети связи
Authors: Журавель Е.П. , Соболев М.В.
Published: September 2024

Рассмотрены аспекты натурного моделирования услуги передачи данных мультисервисной сети связи с коммутацией пакетов, приведены рекомендации по получению практических результатов и получено значение максимальной пропускной способности среды передачи для стека протоколов HTTP/TCPv4/IPv4, составляющее порядка 90% от максимальной пропуск-ной способности сетевых интерфейсов 100 Мбит/с и 1 Гбит/с. На основе результатов моделирования сформирована имитационная модель услуги передачи данных в среде моделирования дискретных событий OMNeT++ с использованием модуля INET на дескриптивном языке описания топологии сети NED, для которой выполнены многофакторные вычислительные эксперименты и получена верхняя оценка точности получаемых результатов, составляющая ±6 %. Предлагаемая модель услуги передачи данных может быть использована для оценки качества предоставления этой услуги в мультисервисной сети связи с обязательным выполнением контроля соответствия модельных значений основных характеристик услуг величинам, полученным в ходе моделирования.
Финишная полировка пластины алмаза в разработанном механическом держателе с контролем качества полировки сканирующими зондовыми микроскопами
Authors: Колесанов А.Ф. , Лаптев А.И. , Логинов Б.А. , Логинов В.Б. , Панкратов А.А. , Полушин Н.И.
Published: September 2024

Разработан механический держатель для полировки тонких алмазных пластин, проведено определение наименьшей шероховатости поверхности алмазных пластин при ручной механической финишной полировке с имитацией режима квазипластичности, подтверждена возможность использования микроскопа СММ 2000 в экспресс анализе при отработке процесса полирования.
Terapi dzikir untuk menurunkan tingkat kecemasan pada pasien hemodialisa
Authors: Farhani Shofa Nadia , Qudsyi Hazhira
Published: September 2024

Chronic Kidney Disease (CKD) is a disease with a high risk of death and the number of patients continues to grow. The majority of patients with CKD undergo hemodialysis as a kidney replacement therapy. By doing hemodialysis for a long period of time, there are various changes that often become stressors that cause anxiety in patients. This study aims to determine the effect of dzikr therapy to reduce anxiety levels. The research design used was one group pre-test post-test with total of 12 patients who had moderate to severe anxiety levels. The instrument used to measure pretest and posttest was Beck & Steer’s BAI anxiety scale (1990). The results of the anxiety scores obtained were processed using the Wilcoxon t-test to determine changes in anxiety scores after the provision of dhikr therapy. The result of Asymp. Sig. of 0.002 (p¡0.05) which indicates that there is a difference in the anxiety level of the participants and there are negative ranks of 6.50 which means that the subject experienced a decrease in anxiety scores. This study shows that dhikr therapy can be used as a method to reduce anxiety in hemodialysis patients.
Gagal ginjal kronik (GGK) merupakan penyakit dengan risiko kematian yang tinggi dan jumlah pasiennya terus bertambah. Mayoritas pasien GGK menjalani hemodialisis sebagai terapi pengganti ginjal. Dengan menjalani hemodialisis dalam jangka waktu yang lama, terjadi berbagai perubahan yang sering kali menjadi stresor yang menimbulkan kecemasan pada pasien. Penelitian ini bertujuan untuk mengetahui pengaruh terapi dzikir terhadap penurunan tingkat kecemasan. Desain penelitian yang digunakan adalah one group pre-test post-test dengan jumlah pasien yang memiliki tingkat kecemasan sedang sampai berat sebanyak 12 orang. Instrumen yang digunakan untuk mengukur pretest dan posttest adalah skala kecemasan BAI Beck & Steer (1990). Hasil skor kecemasan yang diperoleh diolah menggunakan uji t Wilcoxon untuk mengetahui perubahan skor kecemasan setelah pemberian terapi dzikir. Hasil Asymp. Sig. sebesar 0,002 (p = 0,05) yang menunjukkan adanya perbedaan tingkat kecemasan pada partisipan dan terdapat nilai pangkat negatif sebesar 6,50 yang berarti bahwa subjek mengalami penurunan skor kecemasan. Penelitian ini menunjukkan bahwa terapi dzikir dapat digunakan sebagai salah satu metode untuk menurunkan kecemasan pada pasien hemodialisis.