bluuebunny/crossref_metadata_2025 huggingface dataset:
Early prediction of treatment outcome for lenvatinib using 18F-FDG PET/CT in patients with unresectable or advanced thyroid carcinoma refractory to radioiodine treatment: a prospective, multicentre, non-randomised study
Authors: Takeuchi Satoshi , Hirata Kenji , Magota Keiichi , Watanabe Shiro , Moku Rika , Shiiya Akihiko , Taguchi Jun , Ariga Shin , Goda Tomohiro , Ohhara Yoshihito , Noguchi Takurou , Shimizu Yasushi , Kinoshita Ichiro , Honma Rio , Tsuji Yasushi , Homma Akihiro , Dosaka-Akita Hirotoshi
Published: July 2023

Background

Lenvatinib is widely used to treat unresectable and advanced thyroid carcinomas. We aimed to determine whether 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) performed 1 week after lenvatinib treatment initiation could predict treatment outcomes.

Results

This was a prospective, nonrandomised, multicentre study. Patients with pathologically confirmed differentiated thyroid carcinoma (DTC) and lesions refractory to radioiodine treatment were eligible for inclusion. Patients were treated with 24 mg lenvatinib as the initial dose and underwent PET/CT examination 1 week after treatment initiation. Contrast-enhanced CT was scheduled at least 4 weeks later as the gold standard for evaluation. The primary endpoint was to evaluate the discrimination power of maximum standardised uptake value (SUVmax) obtained by PET/CT compared to that obtained by contrast-enhanced CT. Evaluation was performed using the area under the receiver operating characteristic (ROC-AUC) curve. Twenty-one patients were included in this analysis. Receiver operating characteristic (ROC) curve analysis yielded an AUC of 0.714 for SUVmax after 1 week of lenvatinib treatment. The best cut-off value for the treatment response for SUVmax was 15.211. The sensitivity and specificity of this cut-off value were 0.583 and 0.857, respectively. The median progression-free survival was 26.3 months in patients with an under-cut-off value and 19.7 months in patients with an over-cut-off value (P = 0.078).

Conclusions

The therapeutic effects of lenvatinib were detected earlier than those of CT because of decreased FDG uptake on PET/CT. PET/CT examination 1 week after the initiation of lenvatinib treatment may predict treatment outcomes in patients with DTC.

Trial registration: This trial was registered in the University Hospital Medical Information Network (UMIN) Clinical Trials Registry (number UMIN000022592) on 6 June, 2016.
Use of artificial intelligence in discerning the need for prostate biopsy and readiness for clinical practice: a systematic review protocol
Authors: Martinez-Marroquin Elisa , Chau Minh , Turner Murray , Haxhimolla Hodo , Paterson Catherine
Published: July 2023

Background

Variability and inaccuracies in the diagnosis of prostate cancer, and the risk of complications from invasive tests, have been extensively reported in the research literature. To address this, the use of artificial intelligence (AI) has been attracting increased interest in recent years to improve the diagnostic accuracy and objectivity. Although AI literature has reported promising results, further research is needed on the identification of evidence gaps that limit the potential adoption in prostate cancer screening practice.

Methods

A systematic electronic search strategy will be used to identify peer-reviewed articles published from inception to the date of searches and indexed in CINAHL, IEEE Xplore, MEDLINE, Scopus, and Web of Science Core Collection databases. Registries including Cochrane Central Register of Controlled Trials, ClinicalTrials.gov and International Clinical Trials Registry Platform (ICTRP) will be searched for unpublished studies, and experts were invited to provide suitable references. The research and reporting will be based on Cochrane recommendations and PRISMA guidelines, respectively. The screening and quality assessment of the articles will be conducted by two of the authors independently, and conflicts will be resolved by a third author.

Discussion

This systematic review will summarise the use of AI techniques to predict the need for prostate biopsy based on clinical and demographic indicators, including its diagnostic accuracy and readiness for adoption in clinical practice.

Systematic review registration

PROSPERO CRD42022336540
New product development process and case studies for deep-tech academic research to commercialization
Authors: Kruachottikul Pravee , Dumrongvute Poomsiri , Tea-makorn Pinnaree , Kittikowit Santhaya , Amrapala Arisara
Published: July 2023

This research proposes a new product development (NPD) framework for innovation-driven deep-tech research to commercialization and tested it with three case studies of different exploitation methods. The proposed framework, called Augmented Stage-Gate, integrates the next-generation Agile Stage-Gate development process with lean startup and design thinking approaches. The framework consists of six stages and five gates and focuses on critical thinking to help entrepreneurs avoid psychological traps and make the right decisions. Early activities focus on scouting for potential socioeconomically impactful deep-tech research, developing a business case, market analysis, and strategy for problem–solution fit, and then, moving to a build–measure–learn activity with a validated learning feedback loop. Next, suitable exploitation methods are decided using weight factor analysis, developing intellectual property (IP) strategy, completing the university technology transfer process, and participating in fundraising. To pass each gate, the committee board members, consisting of tech, business, IP and regulatory, and domain experts, will evaluate the passing criteria to decide Go/No-Go. Applying the framework to the case studies results in successful university research commercialization. The model, case study, and lessons learned in this paper can be useful for other deep-tech incubator programs to successfully launch deep-tech research for commercialization. The case studies’ positive outcomes validate the Augmented Stage-Gate framework, yet their success is not entirely guaranteed due to external factors like regulatory constraints, entrepreneur characteristics, timing, and the necessary ecosystem or infrastructure, particularly in emerging markets. These factors should be taken into account for future research purposes.
Chronic sildenafil citrate use decreases retinal vascular endothelial growth factor expression in diabetic rats: a pilot study
Authors: Sorour Osama A. , Nassar Elsayed , Sarhan Naglaa , El-Anwar Noha , ElKholy Reem A , Tahoon Dina M. , Sweilam Aalaa , Tadros Dina
Published: July 2023

Background

Sildenafil citrate (SC) attenuates endothelial dysfunction. However, its effects on diabetic retinopathy (DR), which is mainly a microvascular disease, remain unclear. Vascular endothelial growth factor (VEGF) is known to be a critical mediator of DR. Therefore, we investigated the effects of SC on diabetic retina by measuring VEGF levels.

Methods

In this study, twenty-eight rats were divided into the following groups: group I, the control group; group II, rats with streptozotocin-induced diabetes; group III, rats with streptozotocin-induced diabetes receiving daily oral sildenafil at 1 mg/kg; and group IV, rats with streptozotocin-induced diabetes receiving high-dose daily sildenafil at 2.5 mg/kg. After 3 months, VEGF was measured in the retina specimen in one eye and the vitreous body in the other eye by immunohistochemistry and enzyme-linked immunosorbent assay, respectively.

Results

We found that VEGF expression in the retina was low in all rats from groups I and IV and in 30% of rats from group III; 80% of rats in group II demonstrated high VEGF expression in the retinae (P < 0.001). VEGF concentrations in the vitreous body samples were 32 ± 2, 61 ± 4, 44 ± 5, and 36 ± 3 pg/l in groups I–IV, respectively (P < 0.001).

Conclusion

VEGF decreased significantly in the eyes of diabetic rats after chronic oral sildenafil citrate treatment. SC may have a modifying/attenuating effect on DR. However, further studies are needed to evaluate its use as an adjunctive treatment.
Breast metastasis as the first presentation of an anorectal melanoma diagnosed on fine needle aspiration cytology: a case report
Authors: Khan Adil Aziz , Malik Shaivy , Ahuja Sana , Singh Mukul
Published: July 2023

Background

Primary anorectal melanoma is a rare and aggressive disease accounting for approximately 1–3% of all colorectal and anal cancers.

Case report

We present a unique case of anorectal melanoma where the primary presentation was the metastatic breast lump which led to the detection of the primary tumor. A 70-year-old elderly postmenopausal female presented with complaint of left breast lump. On fine needle aspiration cytology, May Grunwald-Giemsa and Papanicolaou stained smears examined were highly cellular and showed sheets, clusters and singly scattered highly pleomorphic plasmacytoid cells having high nucleus to cytoplasmic ratio and scant to moderate cytoplasm with enlarged eccentric round to ovoid nuclei. Immunocytochemistry performed on cell block preparation showed tumor cells strongly positive for HMB-45, S-100 and negative for ER, PR, Her2neu, chromogranin, synaptophysin and Pan-CK. A thorough work up of the patient to look for the site of primary malignancy was done and radiological findings reveled presence of an ill-defined soft tissue mass in the anal canal. Biopsy from the anal mass confirmed the diagnosis of anal melanoma with metastasis to breast.

Conclusion

The present case was reported to emphasize the importance of atypical presentation where the breast lump was the primary presentation of an anal melanoma. Therefore, we should have a strong index of suspicion for metastatic tumors in case of a breast lump especially when there is unusual morphology or unexpected immunophenotype, particularly if the neoplasm is triple-negative, in patients with a previous history of other malignancies.
Home ownership, full-time employment, and other markers of higher socioeconomic status are predictive of shorter time to initial evaluation, shorter time to surgery, and superior postoperative outcomes among lateral patellar instability patients undergoing medial patellofemoral ligament reconstruction
Authors: Shankar Dhruv S. , Avila Amanda , DeClouette Brittany , Vasavada Kinjal D. , Jazrawi Isabella B. , Alaia Michael J. , Gonzalez-Lomas Guillem , Strauss Eric J. , Campbell Kirk A.
Published: July 2023

Background

The purpose of this study was to identify socioeconomic predictors of time to initial evaluation, time to surgery, and postoperative outcomes among lateral patellar instability patients undergoing medial patellofemoral ligament reconstruction (MPFLR).

Methods

We conducted a retrospective review of patients at our institution who underwent primary MPFLR with allograft from 2011 to 2019 and had minimum 12-month follow-up. Patients were administered an email survey in January 2022 to assess symptom history, socioeconomic status, and postoperative outcomes including VAS satisfaction and Kujala score. Predictors of time to initial evaluation, time to surgery, and postoperative outcomes were identified using multivariable linear and logistic regression with stepwise selection.

Results

Seventy patients were included in the cohort (mean age 24.8 years, 72.9% female, mean follow-up time 45.7 months). Mean time to evaluation was 6.4 months (range 0–221) and mean time to surgery was 73.6 months (range 0–444). Having a general health check-up in the year prior to surgery was predictive of shorter time to initial evaluation (β = − 100.5 [− 174.5, − 26.5], p = 0.008). Home ownership was predictive of shorter time to surgery (β = − 56.5 [− 104.7, 8.3], p = 0.02). Full-time employment was predictive of higher VAS satisfaction (β = 14.1 [4.3, 23.9], p = 0.006) and higher Kujala score (β = 8.7 [0.9, 16.5], p = 0.03).

Conclusion

Markers of higher socioeconomic status including having a general check-up in the year prior to surgery, home ownership, and full-time employment were predictive of shorter time to initial evaluation, shorter time to surgery, and superior postoperative outcomes.

Level of evidence: IV, retrospective case series.
MRDPGA: a multiple restart dynamic population genetic algorithm for scheduling road traffic
Authors: Zachariah Babangida , Misra Sanjay , Odion Philip O. , Isah Saidu R.
Published: July 2023

A genetic algorithm is a biologically inspired stochastic approach to finding solutions to optimization problems. However, unlike its deterministic counterpart, it cannot guarantee a globally optimal solution since it may be trapped within a local optimum of the search space. Most researchers have focused on proposing new techniques for various parameters of genetic algorithms. That is a mutation, crossover, or selection algorithm. This research proposes a modification to the standard genetic algorithm, which may serve as a framework that can integrate any of these parameters for their contribution to the final solution of the genetic algorithm. The multiple restart dynamic population genetic algorithm (MRDPGA) proposed in this research was used in training the parameters of the adaptive neuro-fuzzy inference system (ANFIS) for scheduling road vehicular traffic flows. The results of training the ANFIS models based on the different clustering methods showed that the MRDPGA-based ANFIS controller performed better with the mean square error (MSE) of 0.299 and root mean square error (RMSE) of 0.547 in the training phase; and MSE of 0.272 and RMSE of 0.521 in the testing phase. Using the controllers for traffic flow scheduling, the results showed that the MRDPGA-trained controllers performed better in terms of average waiting time (AWT) minimization and total arrived vehicles (TAV). The best-performing controller achieved 50.40% AWT minimization and 21.44% TAV improvement. Analyzing the results using a one-tailed t-test for paired two-sample means showed that the MRDPGA algorithm had a significant impact on the controllers. Particularly the FCM controller, where (p = 0.0038) and (p = 0.0003) for AWT and TAV at a 95% confidence level. Thus, MRDPGA algorithms are recommended for further assessment in other optimization problems to ascertain their performance in those problem domains.
North East England South Asia Mental health Alliance (NEESAMA): an exemplar of global north and global south collaboration to improve research, training and service delivery in mental healthcare
Authors: Devgun Meetali , Kittridge Caitlin , Seshadri Shekhar , Rodgers Jacqueline , Sharma Aditya Narain
Published: July 2023

Despite the worldwide burden of mental illness and recent interest in global approaches to address this, progress on increasing awareness, lessening stigma, reducing the treatment gap, and improving research and training in mental health has been slow. In 2018, the North East England South Asia Mental health Alliance (NEESAMA) was developed as a collaboration between high-income (global north) and low- to middle-income (global south) countries to address this slow progress. This paper outlines how the joint priority areas for research, training and service delivery were identified across the life course (child and adolescent, adults and older people) between partner organisations spanning Afghanistan, Bangladesh, India, Nepal, Pakistan, Sri Lanka and the UK. It describes the progress to date and proposes a way forward for similar alliances to be forged.
Attention-deficit hyperactivity disorder diagnoses and prescriptions in UK primary care, 2000–2018: population-based cohort study
Authors: McKechnie Douglas G. J. , O'Nions Elizabeth , Dunsmuir Sandra , Petersen Irene
Published: July 2023

Background

Rates of diagnosed attention-deficit hyperactivity disorder (ADHD) may be increasing in the UK.

Aims

Estimate incidence and prevalence of ADHD diagnoses and ADHD prescriptions in UK adults and children in primary care.

Method

We conducted a cohort study using IQVIA Medical Research Data, a UK primary care database. Rates of ADHD diagnoses and ADHD prescriptions were calculated between 2000 and 2018 for individuals aged 3–99 years, analysed by age, gender, social deprivation status and calendar year.

Results

Of 7 655 931 individuals, 35 877 (0.5%) had ADHD diagnoses; 18 518 (0.2%) received ADHD medication prescriptions. Diagnoses and prescription rates were greater in men versus women, children versus adults, and deprivation status (nearly double in most deprived versus least deprived quintile). By 2018, the proportion of ADHD diagnoses was 255 per 10 000 (95% CI 247–263) in boys and 67.7 per 10 000 (95% CI 63.5–71.9) in girls; for adults, it was 74.3 per 10 000 (95% CI 72.3–76.2) in men and 20 per 10 000 (95%CI 19.0–21.0) in women. Corresponding figures for prescriptions were 156 per 10 000 (95% CI 150–163) in boys, 36.8 per 10 000 (95% CI 33.8–40.0) in girls, 13.3 per 10 000 (95% CI 12.5–14.1) in men and 4.5 per 10 000 (95% CI 4.1–5.0) in women. Except among 3- to 5-year-olds, the incidence and prevalence of ADHD diagnoses and prescriptions have increased from 2000 to 2018 in all age groups. The absolute increase was highest in children, but the relative increase was largest among adults (e.g. among men aged 18–29 years, approximately 20-fold and nearly 50-fold increases in diagnoses and prescriptions, respectively).

Conclusions

The incidence and prevalence of both ADHD diagnoses and medication are highest among children. Proportionally, rates increased most among adults during 2000–2018. ADHD diagnoses and prescriptions are associated with socioeconomic deprivation.
Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines for Occipital Nerve Stimulation for the Treatment of Patients With Medically Refractory Occipital Neuralgia: Update
Authors: Staudt Michael D. , Hayek Salim M. , Rosenow Joshua M. , Narouze Samer , Arle Jeffrey E. , Pilitsis Julie G. , Schwalb Jason M. , Falowski Steven M. , Sweet Jennifer A.
Published: July 2023

BACKGROUND:

The Guidelines Task Force conducted a systematic review of the relevant literature on occipital nerve stimulation (ONS) for occipital neuralgia (ON) to update the original 2015 guidelines to ensure timeliness and accuracy for clinical practice.

OBJECTIVE:

To conduct a systematic review of the literature and update the evidence-based guidelines on ONS for ON.

METHODS:

The Guidelines Task Force conducted another systematic review of the relevant literature, using the same search terms and strategies used to search PubMed and Embase for relevant literature. The updated search included studies published between 1966 and January 2023. The same inclusion/exclusion criteria as the original guideline were also applied. Abstracts were reviewed, and relevant full text articles were retrieved and graded. Of 307 articles, 18 were retrieved for full-text review and analysis. Recommendations were updated according to new evidence yielded by this update.

RESULTS:

Nine studies were included in the original guideline, reporting the use of ONS as an effective treatment option for patients with medically refractory ON. An additional 6 studies were included in this update. All studies in the original guideline and this current update provide Class III evidence.

CONCLUSION:

Based on the availability of new literature, the current article is a minor update only that does not result in modification of the prior recommendations: Clinicians may use ONS as a treatment option for patients with medically refractory ON.
PERSPECTIVAS PARA CRIAÇÃO DO AUTORREGULADOR FERROVIÁRIO: CONSIDERAÇÕES À LUZ DA EXPERIÊNCIA DOS EUA
Authors: Pinheiro Sampaio Patricia Regina , Lopes Batista Caroline
Published: July 2023

O artigo apresenta as questões jurídicas relevantes na instituição do modelo de autorregulação no setor ferroviário brasileiro, como prevista na Lei nº. 14.273/2021. A metodologia baseia-se na análise legislativa e de bibliografia sobre desregulamentação do setor ferroviário estadunidense e na reforma brasileira. Inicia-se com a apresentação da autorregulação, abordando as vantagens, desvantagens e aspectos essenciais a sua compreensão. Posteriormente, avalia-se o modelo regulatório das ferrovias estadunidenses, com foco no exercício da autorregulação por associações privadas. Na sequência, enfatiza-se as especificidades da legislação e da realidade brasileira. Conclui-se que a experiência da autorregulação nos Estados Unidos é útil, mas possui contexto e modo de implementação distintos do que se pretende adotar no Brasil. A estruturação da autorregulação no setor ferroviário brasileiro deve atentar, em especial, para os aspectos de governança, como exigências de que a entidade reguladora atue sob regras de transparência, não-discriminação entre associados, clareza para a adesão de novos associados e publicidade de seus atos.
Επιμόρφωση εκπαιδευτικών σε θέματα κοινωνικής δικαιοσύνης και επαγγελματική ανάπτυξη
Authors: ΑΛΕΞΟΠΟΥΛΟΥ ΠΕΛΑΓΙΑ
Published: July 2023

Ένα αναδυόμενο ζήτημα  του περιεχομένου της επαγγελματικής ανάπτυξης των εκπαιδευτικών είναι αυτό της προώθησης της κοινωνικής δικαιοσύνης στην εκπαίδευση, καθώς υπάρχει ανάγκη εξισορρόπησης της εκπαίδευσης με το πολυπολιτισμικό περιβάλλον. Η παρούσα έρευνα αποσκοπεί να προσεγγίσει το θέμα της επαγγελματικής ανάπτυξης των εκπαιδευτικών σε ζητήματα κοινωνικής δικαιοσύνης στην εκπαίδευση. Επιχειρεί να διαπιστώσει κατά πόσο η επαγγελματική ανάπτυξη των εκπαιδευτικών περιλαμβάνει θέματα που σχετίζονται με την προώθηση της κοινωνικής δικαιοσύνης στο σχολικό τους περιβάλλον, τη συμβολή των εμπλεκόμενων μελών σε αυτή την κατεύθυνση, καθώς και τη συμβολή της ηγεσίας σε αυτό. Το δείγμα της έρευνάς μας αποτελείται από 144 εν ενεργεία εκπαιδευτικούς (διευθυντές/ντριες και υποδιευθυντές/ντριες) των δημοτικών σχολείων της πόλης του Ρεθύμνου και οι απόψεις τους διερευνήθηκαν με ερευνητικό εργαλείο το ερωτηματολόγιο που σχεδιάστηκε στηριζόμενο στα δεδομένα της υπάρχουσας βιβλιογραφίας. Μέσα από τα ευρήματα της παρούσας έρευνας διαπιστώνεται η ανάγκη και η επιθυμία των συμμετεχόντων/ουσών για βελτίωση των πρακτικών τους στην προώθηση της κοινωνικής δικαιοσύνης στην εκπαίδευση, τονίζεται ο πρωταγωνιστικός ρόλος της ατομικής πρωτοβουλίας, η απουσία καθοδήγησης και επιμόρφωσης και προκύπτει μια σειρά από κατευθύνσεις που θα συμβάλλουν στην προώθηση της κοινωνικής δικαιοσύνης στο περιβάλλον όπου ζουν και αναπτύσσονται τα παιδιά.
Multiple choice question writing and medical students: a systematic literature review
Authors: Lahti Jacob , Salamon Miriam , Farhat Jordan , Varkey Thomas
Published: July 2023

Background: Multiple-choice question (MCQ) tests have been the standard for ensuring fairness and ease of grading within school curricula for several years. Students, teachers, and researchers alike have developed methods and materials to improve performance on MCQ tests. One practice of interest to the research team is students writing their own multiple-choice questions as a learning methodology. This study intends to review the current literature to assess the validity of student-written MCQs as a study technique.

Methods: This literature review was performed following the PRISMA guidelines. Relevant articles were pulled via a systematic search of various databases (Google Scholar, Cochrane, and PubMed) performed on 7.17.2022. Forty-seven non-duplicated articles were extracted. These were then limited, following full text evaluation, to a total of five articles.

Results: In three out of the five articles there were positive subjective views of the use of MCQ writing as a method for studying, and one article showed that the students did not feel that the process helped them or provided value. In two of the five articles, data was collected on how MCQ writing worked in comparison with students that were not writing MCQs, and results demonstrated that those students who wrote MCQs more frequently demonstrated better exam scores as compared to those who did not use MCQ writing as a study method or utilized it infrequently.

Conclusions: This literature review demonstrated some of the preliminary work that has been done thus far on the utility of MCQ writing as a learning tool in medical education. While still limited in overall understanding of the effects of the use of this method, there remains much promise for its use in the medical student population. It is the hope of the authors that further work be done on this question for the benefits of the students.
The Avon Longitudinal Study of Parents and children ALSPAC G0 Partners: A cohort profile
Authors: Northstone Kate , Ben Shlomo Yoav , Teyhan Alison , Hill Amanda , Groom Alix , Mumme Mark , Timpson Nic , Golding Jean
Published: July 2023

ALSPAC is an ongoing population-based, observational study designed to investigate how genetic/environmental characteristics might influence the health/development of children and their parents. It has evolved to facilitate the measurement of many outcomes in the parental cohort. Pregnant women resident in Bristol, UK with expected dates of delivery between April 1991-December 1992 were eligible. 14,541 pregnancies were originally enrolled. Partners of the pregnant women were initially invited to take part by the women with formal enrolment of individuals since 2010. Data has been collected from 12,113 partners, with 3,807 formally enrolled. Data collected to date: 21 questionnaires, clinical follow up in 2012 (mean age: 53 years) and a family-based clinical follow-up currently ongoing (mean age: 63 years). Questionnaires have asked about a wide range of environmental measures, physical/mental health and other phenotypic details at regular timepoints up to 2005, once in 2012 and regularly again since 2018, including six questionnaires completed during the COVID-19 pandemic. Clinical measures include anthropometrics, blood pressure, body composition, cardiovascular health and a fasting blood sample. DNA has been extracted with genome-wide data available on >3,000 partners and exomes on ~1500 trios. The data contributes to one of the most deeply phenotyped birth cohorts in the world, providing trios of data, allowing comparison between parents and offering multi-generational information, and is fully accessible through a managed access process.
Shunt fracture as a sequela of cervical spine manipulation: a case report
Authors: Kim El
Published: July 2023

Shunt disconnection is an unreported complication of spinal mobilization and manipulation. We present the case of a young adult who underwent cystoperitoneal (CP) shunt placement for an arachnoid cyst at the age of 6 years. The shunt remained functional during a follow-up period of 11 years. The patient was admitted with headache and diplopia that started after cervical manipulation by a chiropractor. Radiography revealed fracture of the distal catheter and resultant enlargement of the temporosylvian cyst. The patient required replacement of the disconnected tubing caudal to the shunt valve. The distal catheter ruptured immediately below the outlet connector of the valve. The symptoms and signs resolved completely after insertion of a new distal tube into the peritoneum. This case report demonstrates that chiropractic manipulation of the neck may be a cause of tubing breakage in patients with CP shunts.
Dwie misje rotmistrza Bolesława Długoszowskiego „Wieniawy” do Paryża w 1919 roku. Część 2: Emisariusz Belwederu przy szefie Francuskiej Misji Wojskowej w Polsce
Authors: Wołos Mariusz
Published: July 2023

Celem artykułu jest przedstawienie dwóch misji dyplomatyczno-wojskowych Bolesława Długoszowskiego „Wieniawy” do Paryża w pierwszej połowie 1919 r. W obu przypadkach był on wysłannikiem Józefa Piłsudskiego, którego interesy reprezentował we Francji w okresie paryskiej konferencji pokojowej. W trakcie misji Długoszowski zajmował się kluczowymi problemami związanymi z odbudową państwa polskiego, w tym wzmocnieniem jego potencjału militarnego, nawiązaniem stosunków z państwami ententy oraz Komitetem Narodowym Polskim.
Minister Henryk Juliusz Floyar-Rajchman jako polski polityk na uchodźstwie
Authors: Piotrowski Jacek
Published: July 2023

W oparciu o materiały archiwalne, głównie z Instytutu Józefa Piłsudskiego w Ameryce, artykuł przedstawia sylwetkę Henryka Juliusza Floyara-Rajchmana. Polski minister przemysłu i handlu w latach 1934–1935, pochodzenia żydowskiego, podczas wojny i później na uchodźstwie odegrał istotną rolę. Najpierw ratował złoto Banku Polskiego i Fundusz Obrony Narodowej dla dalszej walki u boku aliantów. Następnie współtworzył liczące się środowisko polityczne piłsudczyków w Stanach Zjednoczonych. Do śmierci pozostał „nieugiętym niepodległościowcem” strzegącym praw i granic II Rzeczypospolitej, w której miał honor być ministrem.
Agentura sowiecka w Armii Polskiej w ZSRR (wrzesień 1941 – sierpień 1942)
Authors: Jaczyński Stanisław
Published: July 2023

Artykuł przedstawia działalność agentury sowieckiej w Armii Polskiej organizowanej na terytorium ZSRR. Armia Polska w ZSRR była penetrowana nie tylko przez konfidentów NKWD, ale też przez skierowanych w jej szeregi agentów Komitetu Wykonawczego Międzynarodówki Komunistycznej (Kominternu). Agenci mieli za zadanie zdobywanie informacji o wewnętrznych stosunkach w polskich dowództwach i oddziałach i panujących w nich nastrojach antyradzieckich. Funkcje wywiadowcze pełnili też radzieccy oficerowie łącznikowi.
„Rozstrzelani za Zbruczem”. Praktyka wydawania wyroków śmierci na ludność polską w trzech obwodach Ukraińskiej SRR w ramach „operacji polskiej” w latach 1937–1938. Analiza komparatystyczna
Authors: Olechowski Piotr
Published: July 2023

Tekst przedstawia trzy przypadki śledztw karnych toczonych w latach trzydziestych XX w. przeciwko ludności polskiej pozostałej na Ukrainie Radzieckiej (Winnica, Odessa, Kamieniec Podolski). Wszystkie zakończyły się wyrokami skazującymi na śmierć przez rozstrzelanie. Po latach zamordowani zostali uznani za ofiary systemu totalitarnego, uzyskując tym samym pośmiertną (symboliczną) rehabilitację.
Wydawnictwo Dobra Powszedniego (1982–1986)
Authors: Knoch Konrad
Published: July 2023

W tekście zaprezentowano historię podziemnego Wydawnictwa Dobra Powszedniego, które powstało w czasie stanu wojennego w Ryjewie z inicjatywy studentów Uniwersytetu Gdańskiego. Dzięki badaniom archiwalnym i relacjom ustnym udało się ustalić genezę powstania podziemnej oficyny wydawniczej, miejsca i sposoby druku, część tytułów wydrukowanych przez Wydawnictwo Dobra Powszedniego oraz scharakteryzować system dystrybucji. Skupiono się również na lokalnej specyfice inicjatywy i związanych z tym problemów organizacyjnych.
Convergence and well-posedness properties of uniformly locally contractive mappings
Authors: Reich Simeon , Zaslavski Alexander J.
Published: July 2023

In a 1961 paper by E. Rakotch it was shown that a uniformly locally contractive
mapping has a fixed point. In the present paper we show that for such a mapping,
the fixed point problem is well posed and that inexact iterates of such a mapping
converge to its unique fixed point, uniformly on bounded sets. Using the porosity
notion, we also show that most uniformly locally nonexpansive mappings are, in fact, uniformly locally contractive.
Halpern-type proximal point algorithm in CAT(0) spaces
Authors: Okeke Chibueze Christian
Published: July 2023

A method which is a combination of the Halpern method and proximal point method
(PPA) is introduced in this paper. It is proved that the sequence of iterates generated by our method converges strongly
to a point which is a common solution to some monotone inclusion problem and fixed point problem in CAT$(0)$ spaces under some appropriate conditions.
Wykorzystanie nowoczesnych technologii na polu szerzenia idei czytelnictwa na przykładzie działań Publicznej Biblioteki Pedagogicznej Książnicy Pedagogicznej im. A. Parczewskiego w Kaliszu
Authors: Pomiecińska Róża
Published: July 2023

For many years, the Kalisz Pedagogical Library has been actively participating in the process of the use of modern technologies in favour of the reading promotion. The last two years of the pandemic COVID-19 showed in a particular way how much can be achieved using various informational and communicational technologies (TIK), for awaking the reading interests among different social groups. The article presents exemplary activities with the usage of TIK tools employed in the teacher-librarian’s everyday work in the context of the reading development. The following activities, among others, are worthy of note: meetings of the Network of Cooperation and Self-Learning of Teachers – the TIK Teacher, creating digital didactic materials, and organisation of other meetings. The author describes games, quizes, blogs, and digital escape rooms of different kinds, which also contribute to the reading development, especially among children and youth that go to libraries. Furthermore, the author pays attention to publications which present the activities of librarians from the Kalisz Pedagogical Library within the scope of using the modern technologies in education.
Działalność wydawnicza bibliotek pedagogicznych
Authors: Fluda-Krokos Agnieszka
Published: July 2023

The article results from research concerning publishing activity, creating publications and their distribution by teachers of librarians from 23 selected pedagogical libraries. The catalogue of the National Library, the registry “Połączone katalogi” [“Combined catalogues”] were used as a basis for this excerption. The search was conducted according to the phrases: pedagogical library and publishing house, with confining to the facets: author/creator, form and type, genre, theme, field and view, cities. Examples of the publishing activities have been given. The presented results of studies and lists of data show the pedagogical libraries as active participants of the publishing market in Poland.
Mindfulness – stan umysłu
Authors: Łętocha Krystyna
Published: July 2023

The article presents issues connected with the question of mindfulness and its positive influence on different spheres of the human life. It discusses themes of the centuries-old tradition of mindfulness and its practice; the results of research which confirm its saving influence on the human mind are given. The subject is considered in the context of education and, particularly, benefits resulting from the practice of mindfulness both by pupils and teachers.
Optimizing the Creativity of Reflective and Impulsive Students through Writing Articles Based on Information Literacy
Authors: Cintamulya Imas , Mawartiningsih Lilik , Warli Warli
Published: July 2023

Creativity and information literacy are skills necessary for students for task completion in the learning process. One of the tasks assigned to students in learning is to write drafts of scientific articles. Furthermore, teachers must pay attention to cognitive styles in the learning process. This study aimed to describe students' creativity in writing drafts of scientific papers based on information literacy concerning reflective and impulsive cognitive styles. This research was exploratory qualitative research to explain the creativity of reflective and impulsive students in writing scientific article drafts based on information literacy. The research subjects comprised two students for each reflective and impulsive cognitive style. The cognitive style was measured using the Matching Familiar Figure Test instrument. Students' creativity was measured using a test with fluency, flexibility, originality, and elaboration indicators. The results indicated that reflective students were highly creative in writing drafts of scientific articles. Meanwhile, impulsive students were relatively creative in the same activity. In conclusion, students possessing the reflective cognitive style are more creative than students following the impulsive cognitive style in writing drafts of scientific articles based on information literacy. We recommend that writing articles based on information literacy is required to increase HOTs (Higher Order Thinking Skills).
Advertising Management of Early Childhood Education Institution: Challenges, Opportunities, and Development
Authors: Rasmani Upik Elok Endang , Sarifudin Alfan , Wahyuningsih Siti , Nurjanah Novita Eka , Jumiatmoko Jumiatmoko , Zuhro Nurul Shofiatin , Fitrianingtyas Anjar , Winarji Bambang , Widiastuti Yuanita Kristiani Wahyu
Published: July 2023

Advertising or promotion management analyses, plans, and monitors programs to create target market exchanges and achieve institutional goals. Early childhood education (ECE) is an educational institution needing advertising management. This study examines the implementation of ECE advertising management in terms of challenges, opportunities, and developments. This study showed two major areas: 1) practitioners were more innovative and creative in using technology to develop advertising management, and 2) the educational institution got better recognition from society, especially parents. This study uses the literature study method, assisted by the publish perish application, to find reference sources related to educational advertising management for ECE. The study showed that the ability of schools and teachers to provide services based on consumers’ demands influenced the implementation of organisational advertising management challenges. Meanwhile, advertising management developments were sometimes affected by the actions of the advertising media. Social media informed consumers about the institution without spending more money and effort.
Future Clouds
Authors: Kidder Hodges Benjamin
Published: July 2023

This article uses diatoms and the role they play in cloud formation as a prompt to consider histories of weather modification in practice, science fiction and possible future applications to address climate change. Diatoms are a form of microalgae that are present in all waterways and contribute significantly to atmospheric oxygen. They also provide condensation nuclei around which water droplets form, effectively creating clouds. Such naturally occurring particulate matter interacts with intentional and unintentional anthropogenic influence on the atmosphere. The long history of folk speculation and scientific experimentation about effective ways of seeding clouds for rain can help us consider the potential impacts of new forms of atmospheric intervention. From the use of algae as a tool for bioremediation to marine cloud brightening techniques, a multiscalar ecological awareness needs to be publicly fostered in making choices about how to influence climate futures.
Nessie and Noctilucent Clouds
Authors: Smith Oliver D.
Published: July 2023

Since the 1930s there have been over a thousand recorded sightings of monsters in Loch Ness, Scotland. The consensus of experts is these reports of mysterious creatures (known in Scottish Highlands folklore as Nessie) have mundane or prosaic explanations such as hoaxes, wakes, mirages, misidentifications of floating objects (e.g., natural debris, boats) and known native fauna (e.g., deer, otters, diving birds), opposed to extraordinary or unusual explanations such as exotic fauna, escaped animals from traveling circuses, relict plesiosaurs and unknown or elusive species (e.g., ‘long-necked’ pinniped, giant eel). After providing an overview of the different hypotheses and a history of the search for the Loch Ness Monster – the author of this paper argues a rare meteorological phenomenon might explain some monster sightings in the loch during twilight hours between May and August – reflections of noctilucent clouds (NLCs).
Effects of Atmosphere in Andrew McGahan’s “The Rich Man’s House”
Authors: Mitchell Marea
Published: July 2023

Receiving an Aurealis Award for best horror novel in 2019, The Rich Man’s House tells the story of events that unfold within and around the mansion commissioned by Walter Richman on a mythical mountain in the Southern Ocean near Tasmania, Australia. The external atmosphere around Richman’s house consists of elemental forces or “presences” that become increasingly sinister. These external elements and the architectural atmosphere of the house create disturbing uncertainties about how to interpret the events of the novel. Collapsing traditional notions of background and foreground, McGahan’s novel is susceptible to “an atmospheric reading” (Chandler, 199) that includes but exceeds the fogs, clouds, mists and winds that are its partial constituents.
Extraordinarily Hazardous
Authors: Hayward Philip R
Published: July 2023

This article examines the disruptive role that fog and associated weather conditions play in human livelihood activities undertaken on and around the Grand Banks of the north-western Atlantic, the affective atmosphere they create and their effect on human participants. After an introduction to the position and nature of the Grand Banks, relevant weather systems, ocean currents and iceberg trajectories through the region, the article profiles the nature of fishing (and, subsequently, oil extraction) in the area, of the precarity of livelihood activities undertaken and their reflection and inscription in various media. This approach identifies the manner in which aquapelagos (integrated terrestrial and marine systems) are not necessarily safe or stable entities – even in the shortest of terms – and can, indeed, represent assemblages in which humans are stressed and threatened. Within this, the case study examines the manner in which fog is not so much an uncomfortable intrusion into an otherwise manageable industrial operation as a key characteristic to be accommodated. The experience of fog is crucial to the social experience of the Grand Banks and of the aquapelago that is constituted around it. Substantial consideration is also given to the atmospherics of Grand Banks fog in literature and visual art and of the imaginative space created for it.
¿Por qué la emoción antecede la cognición?
Authors: Segura Delgado Paula Andrea , Ramírez-Bahena Martha Helena
Published: July 2023

La neuroeducación comparte la importancia y necesidad de la vinculación de saberes neurocientíficos para el enriquecimiento de la epistemología y práctica docente; diversas experiencias educativas han aceptado el valor transcendental de las emociones para el logro de un aprendizaje significativo y emocional. Con los objetivos de lograr en la comunidad docente una alfabetización conceptual neurocientífica para comprender desde saberes de la neurociencia diferentes resultados positivos de experiencias educativas integradas al factor socioemocional, se presenta una revisión bibliográfica sobre conocimiento neurofisiológico que permite entender cómo aprende el cerebro junto a la relación unidireccional del suprasistema emocional-cognitivo. Así mismo, la plasticidad cerebral y las neuronas espejo son decisivas para el aprendizaje de habilidades socio-afectivas que permitan el desarrollo de personas sanas que se impliquen en la mejora de la sociedad.  Actualmente se presenta la necesidad de entenderse la educación como un entorno de desarrollo social con enfoque emocional, mediante prácticas educativas coherentes a la naturaleza social del cerebro quien ha presentado una evolución biológica lenta y anticuada para la actual realidad social vertiginosa, que enfrenta situaciones sociales difíciles como lo son la violencia, estrés y depresión. Se concluye, gracias a la correspondencia de los avances teóricos de las neurociencias y la educación el deber ser la formación educativa adaptada la neurofisiología cerebral.
Aportaciones de la traumaterapia en la atención educativa al alumnado con dificultades en la convivencia, la conducta o el aprendizaje
Authors: Remiro Beatriz
Published: July 2023

Ante el reto que supone para los centros educativos la atención al alumnado con necesidades educativas muy diversas, y en concreto a los que pueden sufrir alguna alteración en el funcionamiento del sistema nervioso debido a la vivencia de situaciones traumáticas en la primera infancia, se aporta una experiencia basada en la traumaterapia desde el modelo que proponen Barudy y Dantagnan. En el marco de la orientación educativa en centros de educación infantil y primaria se proponen actuaciones para promover la comprensión de las dificultades de convivencia, conducta y aprendizaje; la reflexión sobre las actuaciones que pueden prevenirlas y sobre las que se requieren para intervenir cuando surgen; así como la necesidad de acompañamiento a todos los miembros de la comunidad educativa en estas tareas. En el artículo se muestran experiencias con profesionales de la educación, con familiares y con alumnos y alumnas. En todos los casos, pero sobre todo respecto al alumnado, se relatan actuaciones preventivas y reactivas, poniendo énfasis en la prevención para disminuir la necesidad de determinar y clasificar las dificultades en un diagnóstico y aumentar la posibilidad de intervenir en el contexto antes que con los niños de forma individual, mediante actuaciones específicas que pueden interferir en las posibilidades de normalizar la respuesta educativa. Se estima necesario un análisis de experiencias que han mostrado su eficacia en la atención e inclusión de alumnado con dificultades de conducta graves, así como formación y acompañamiento para atenderlas, dado que se trata de afectaciones que generan sufrimiento y frustración, tanto en los niños y en las niñas como en los adultos que tratan de educarles, por la enorme dificultad que entrañan, sobre todo si no se abordan desde un marco teórico explicativo suficientemente bueno.
La tarea crítica en Judith Butler: de la teoría de la performatividad de género a una teoría performativa de la asamblea
Authors: Dahbar María Victoria
Published: July 2023

La tarea crítica en la obra de Judith Butler se halla en su reflexión sobre las normas que regulan la reproducción del sujeto, las ocasiones en que esa normatividad falla, y el eventual establecimiento de nuevas normas, una ruptura posible por el carácter performativo de su funcionamiento, su repetición diferenciada. Conforme su reflexión fue cambiando de intereses, puede reconocerse una transición en su propia idea de crítica. Antes que señalar cortes radicales entre un período y otro de su producción, este artículo señala las continuidades: es justamente a partir de su crítica a las normas que producen el sujeto sexuado, que Butler realiza años más tarde una crítica a la violencia de las normas que regulan al sujeto más allá del sistema sexo-género. Sostenida en una ontología sociocorporal de los cuerpos siempre en alianza, esta etapa considera a la crítica como una relación singular aunque colectiva con las normas, y avanza en una discusión con las ontologías liberales y sus implicancias políticas. A través del análisis del lugar que fue adquiriendo la crítica en su programa filosófico este texto avanza mediante el desarrollo de tres nociones capitales: violencia normativa, performatividad, e interrupción.
A percepção institucional da república velha no 'Auto da Compadecida': entre Victor Nunes Leal e Ariano Suassuna
Authors: Morais Ricardo Manoel Oliveira , Rezende Andrade Luiza
Published: July 2023

O objetivo deste artigo é analisar a percepção das instituições e da aplicação da lei na realidade brasileira da República Velha a partir da manifestação artística cômica de Ariano Suassuna. Para a compreensão e a análise da República Velha – período compreendido entre 1889 e 1930, também denominado por República Oligárquica, 1ª República ou República do Café com Leite –, o marco teórico é o Coronelismo, Enxada e Voto, de Victor Nunes Leal. Sobre a percepção e as representações populares cômica da lei e das instituições, a peça escolhida é o Auto da Compadecida, de Ariano Suassuna. O paralelo entre as obras visa a evidenciar um distanciamento entre a esfera pública brasileira do final do século XIX e início do XX – e tudo o que dela decorre, como as leis, os processos de tomada de decisões políticas, a relação entre cidadãos e autoridades “legitimamente constituídas” – e a realidade social.