bluuebunny/crossref_metadata_2025 huggingface dataset:
La réforme du droit de l’adoption internationale en Allemagne
Authors: Budzikiewicz Christine
Published: July 2021

The German private international law on adoption has long been considered in need of reform. Above all, the criticism concerned the fact, that the (complex) connecting factor under the conflict of law rules, which primarily took into account the interests of the adopter(s), was n° longer up to date. A decision of the German Federal Constitutional Court finally gave the impulse for a reform of the conflict-of-law rules. The legislature had been instructed to implement a change in the substantive adoption law by 31 March 2020. The subject matter of the reform was the (previously excluded) stepchild adoption in non-marital partnerships. The corresponding change in substantive law resulted in a need for adaptation in private international law. On this occasion, the legislature took the opportunity to fundamentally reform the relevant regulations. The amendments came into force on 31 March 2020. An adoption in Germany is now always subject to German law. Otherwise, it is subject to the law of the state in which the person to be adopted has his or her habitual residence at the time of adoption. For potential requirements of consent, the old law provided for a supplementary connection to the national law of the person to be adopted. This is n° longer the case in the new law. The following article provides an overview of the new regulation and explains the background.
Lafarge : de l’internationalisation à la firme mondiale, une résistible ascension ? (1947-2014)
Authors: Barjot Dominique
Published: July 2021

Jusqu’à sa fusion en 2014, avec Holcim, son principal concurrent européen, Lafarge a offert un bon exemple d’entreprise française devenue mondiale. Numéro deux français des matériaux de construction derrière Saint-Gobain, Lafarge s’est imposée avec un succès comparable. Elle le doit à une internationalisation précoce. Fondée en 1833, la maison Lafarge est demeurée longtemps familiale, avant de se transformer, à partir de 1947, en firme managériale. Depuis cette date, deux périodes se sont succédées. De 1947 à 1992, l’entreprise s’est progressivement multinationalisée. Les années 1947 à 1973 ont été marquées par une croissance forte financée par autofinancement, élargissement limité de l’actionnariat et endettement à long et moyen terme. Trois facteurs ont alors cumulé leurs effets positifs : un management rationnel (passage au staff and line , en privilégiant une logique multidivisionnelle), une stratégie réussie de redéploiement international de l’Afrique francophone vers l’Amérique du Nord et un effort de recherche-développement très supérieur à celui de la concurrence. Ces choix ont permis, dans un environnement économique plus difficile, de consolider les positions internationales du groupe par la conquête du marché américain, où le groupe s’est imposé, de 1974 à 1992, comme le numéro 1, tout en se renforçant en Europe. Dans les années 1993 à 2007, le groupe Lafarge s’est imposé comme une firme de dimension mondiale en privilégiant le renforcement de ses positions nord-américaines et la conquête des pays émergents. Toutefois, pour financer une croissance rapide, tant organique qu’externe, il a fallu satisfaire un actionnariat de plus en plus éclaté et flottant. Ce n’est qu’à partir de 2008 que l’actionnariat s’est stabilisé, mais au prix d’une perte d’indépendance stratégique. Celle-ci a conduit à la fusion. Certes, elle a donné naissance à un leader mondial, mais au sein duquel la technostructure managériale a perdu le pouvoir au profit de la famille Schmidheiny et de ses alliés belges et égyptiens, d’où la nationalité suisse de l’actuel LafargeHolcim.
La stratégie de Renault en Russie des années 1960 à nos jours
Authors: Vinogradov Boris
Published: July 2021

L’industrie automobile française demeure aujourd’hui l’une des plus importantes du monde : en 2018, son industrie automobile nationale plaçait la France à la dixième place des producteurs mondiaux et au troisième rang en Europe. Les positions de Renault apparaissent particulièrement fortes en Russie. Le constructeur automobile français maintient sa présence sur le marché russe, malgré les nombreux bouleversements que connaît le pays au XX e  siècle. À l’époque soviétique, la marque au losange réussit de nombreux projets industriels sur le territoire de l’URSS et réalise un transfert d’importance des technologies. Après la chute de l’Union soviétique, Renault investit dans la construction d’une usine automobile à Moscou. L’usine « Renault Russie » devient en 2014, la quatrième usine du Groupe Renault en volume de production. Il s’agira ici d’observer et d’expliquer la stratégie de la marque sur le marché russe.
Virgin France, coup d’essai de l’internationalisation d’un groupe entre opportunisme et décentralisation
Authors: Champroux Nathalie Anna
Published: July 2021

La France fut le pays tremplin de l’internationalisation du groupe britannique Virgin. Au début des années 1980, Virgin parvint à y implanter avec succès Virgin France SA, la première filiale étrangère de son label britannique d’édition phonographique, Virgin Records. En 1988, la France s’enrichit d’une autre activité de la maison mère britannique : la vente de produits culturels. Virgin Stores SA, société bien française malgré son nom anglophone, inaugura la série de filiales étrangères de la britannique Virgin Retail ; elle fut à l’origine du premier Virgin Megastore ouvert hors du Royaume-Uni, sur l’avenue des Champs-Élysées de Paris. Le cas de la création et de l’évolution de ces deux filiales françaises de Virgin présente l’intérêt d’alimenter les théories privilégiant l’opportunisme, l’influence des réseaux et la décentralisation comme moteurs de l’internationalisation des entreprises de service. Virgin France SA n’est pas née d’une stratégie d’internationalisation mûrement planifiée en réponse au besoin désespéré de fuir un marché intérieur saturé ou de satisfaire des partenaires financiers exigeants. Plutôt, la filiale fut le fruit du hasard d’une rencontre entre le français Patrick Zelnik et le britannique Richard Branson. L’enthousiasme du premier, alors directeur du marketing chez Polydor, a nourri chez le second, fondateur et patron de Virgin, l’idée d’une filiale française. Le lien social qui se tissa entre les deux hommes incita ensuite Branson à laisser carte-blanche à Zelnik. Bien ancré dans le marché de l’industrie créative en plein essor dans les années 1980, ce fut ce dernier qui eut l’idée de concurrencer la FNAC, chaîne de distribution de produits culturels déjà bien implantée dans l’Hexagone, avec un Virgin Megastore parisien. Ce sont ces deux incursions particulières de Virgin sur le marché français qu’il s’agit d’étudier ici, dans ce qu’elles révèlent du processus d’internationalisation du groupe.
Appraisal Survey of the Knowledge, Attitudes, and Behaviors of Jordanian Society toward Diet and Nutrition during Covid-19 Era
Authors: Alhaj Omar A. , Al-Sayyed Hiba F. , AlRasheed Maha M. , Jahrami Haitham
Published: July 2021

Background

This study aimed to evaluate the knowledge, attitudes, and behavior (KAB) of the Jordanian society toward nutrition and diet during the COVID-19 era.

Design and methods

This study is an observational, crosssectional study using a structured, validated, reproducible, selfadministered online Arabic questionnaire. KAB of the study participants was assessed via a web-based, structured, validated, reproducible Arabic questionnaire. The tool for the assessment of the KAB was composed of 33-closed-ended multi-answer questions.

Results

A total of 672 people were surveyed, 70.2% were between 18 and 34, and 69.5% were females. Participants have paid little attention to the healthfulness of their diet in the last year. The majority of participant's attitudes towards using different approaches to manage weight in the next year were: eating smaller portions for weight management, tracking to maximize the amount of time of physical activity, and substituting lowercalorie foods for full-calorie alternatives. Only tenth of participants utilize the time to perform physical activity. The majority made changes to their diet and exercise, and strictly follow commitment in connection with planning for the following year.

Conclusions

Educators, legislatives, food manufacturers, household heads, and policymakers are called upon to improve Jordanians’ KAB on nutrition and diet. Furthermore, Jordanian nutrition and diet behavior can be invested to improve the dietary interventions designed by nutrition and dietetics professionals.
Tailoring antituberculosis treatment regimen in a patient with serious adverse drug reactions to multiple drugs
Authors: Subbalaxmi M. V. S. , Bagadi Suneel Kumar , Baddepuram Sandeep , Soanker Radhika
Published: July 2021

Stevens–Johnson syndrome (SJS) and hepatitis are serious adverse drug reactions following the administration of anti-tuberculosis treatment (ATT). Here, we report a case of a young woman who developed hepatitis and SJS following ATT. Identifying the culprit drug and tailoring the appropriate regimen is a challenge to the clinicians. We described the clinical features, laboratory findings, hospital course and follow-up in a young female with tuberculosis, SJS and hepatitis in the case report. After the resolution of hepatitis, we confirmed the diagnosis of extrapulmonary tuberculosis and treated her after a cautious rechallenge with antitubercular drugs.
Anaesthetic management for electroconvulsive therapy during the second trimester pregnancy
Authors: Sreehari K. G. , Babu Jeevan , Radha J. , Jamuna T. , Krishna I. Vamsi , Reddy V. Rambhoopal
Published: July 2021

Electroconvulsive therapy (ECT) is a highly effective treatment for patients with psychotic disorders that do not respond to medication. Usually, many psychotropic drugs have a teratogenic effect on the foetus. ECT seems to be a relatively safe and effective choice of treatment in pregnant patients. Adverse events such as foetal heart rate reduction, uterine contractions and premature labour do occur during ECT. We report our experience with ECT in the treatment of first episode of mania with psychosis in a patient in second trimester of pregnancy.
Stevens–Johnson syndrome/toxic epidermal necrolysis overlap syndrome due to oral phenytoin
Authors: Harikrishna J. , Pradeep Vasili , Reddy V. Devika , Kumar M. Krishna , Surekha A. , Surya Durga Devi Pilla S. , Mohan Alladi
Published: July 2021

Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but lethal manifestation of hypersensitivity reaction precipitated by certain drugs and viral infections. Among the drugs, it is more common with antibiotics, antiepileptics and nonsteroidal anti-inflammatory drugs. We report the case of a 14-year-old male who presented to the medicine out-patient department with a history of fever since the previous day. Four days before this, he had developed an episode of generalised tonic–clonic seizures and was initiated on oral phenytoin since then. Following admission to the medical intensive care unit, fever persisted on the 2nd day as well. The patient developed a maculopapular rash over face and trunk, ulceration over lips and skin peeling involving >10% <30% body surface area suggestive of SJS/TEN overlap syndrome. Oral phenytoin was stopped, and he was started on oral levetiracetam. He was treated with intravenous corticosteroids, topical antibiotics and symptomatic management. The patient recovered, skin lesions subsided and he discharged in a stable condition after 2 weeks of in-hospital stay. The present case documents the rare occurrence of SJS/TEN overlap syndrome as an adverse drug reaction caused by phenytoin. Early identification and stopping of offending drug will aid in better management of the patient.
Validation of surgical APGAR score in abdominal surgeries at a tertiary care teaching hospital in South India
Authors: Bhushanam K. Yadhu , Samantaray Aloka , Thottikat Kaarthika , Pasupuleti Hemalatha , Devi R. Sri , Rao Mangu Hanumantha , Chukkaluru Sumadhu
Published: July 2021

Background:

A ten-point surgical APGAR score (SAS) has been previously developed and validated that provides surgeons with a simple, objective and direct rating of operative performance and risk. This score has been evaluated in different types of surgeries till date. We validated SAS in both elective and emergency abdominal surgeries separately which was not done previously.

Methods:

In this prospective, observational and longitudinal study, 105 surgical cases undergoing open abdominal surgeries were studied. The SAS was calculated for all patients, patients were followed up for the occurrence of any major complications or mortality during hospital stay after surgery. All the patients were divided into three groups based on their SAS score (high risk: SAS 0–4, moderate risk: SAS 5–7 and low risk: SAS 8–10) using a threshold that has been previously established.

Results:

The occurrence of major complications was significantly higher in high-risk SAS group (12%) than in the moderate risk group (5%). In the low-risk SAS group, the occurrence of major complications was low (1%). The mortality rate in high-risk SAS was more than that in low-risk SAS group with statistical significance both in elective and emergency cases.

Conclusions:

In our study, we found that patients who belong to high-risk SAS group were significantly associated with post-operative major complications and mortality in both elective and emergency surgeries. A patient with low intraoperative SAS should be considered at risk and monitored meticulously.

Trial Registration:

Clinical Trials Registry-India (CTRI) identifier No. CTRI/2019/02/017567.
Microsponge
Authors: Nidhi Kumari , Verma Shubham , Kumar Sokindra
Published: July 2021

Microsponge drug delivery system (MDS) was developed to deliver the pharmaceutical ingredients efficiently at the site of administration at a limited dose. MDS is based on pore size of sponges. The action of microsponges lasts up to 12 hours. MDS is also dependent on the physicochemical properties of the drug. These are used in bone tissue engineering, for reducing skin irritation and have a self-sterilisation property. This review provides an overview regarding the characteristics, methods of preparation, properties, evaluation, applications and limitations of MDS.
Circulating serum micro-ribonucleic acids 155 and 205 before and after surgery in patients with breast cancer
Authors: Rama K. , Bitla Aparna R. , Hulikal Narendra , Yootla Mutheeswaraiah , Yadagiri Lakshmi Amancharla , Asha T. , Manickavasagam M. , Srinivasa Rao P. V. L. N.
Published: July 2021

Background:

Micro-ribonucleic acids (miRNAs) are small non-coding RNAs that regulate gene expression. Expression of miRNAs has been shown to be dysregulated in patients with breast cancer. These markers have been shown to be potential markers of diagnostic significance. We intended to study the usefulness of miRNA-155 and miRNA-205 in monitoring response to surgery by monitoring their pre- and post-operative expression.

Methods:

Twenty patients newly diagnosed with malignant breast disease along with 20 age-matched females not having any breast lesion were included in the study. Reverse transcription–polymerase chain reaction was used to assess the expression of circulating miRNAs.

Results:

MiRNA-155 was found to be significantly upregulated and miRNA-205 was significantly downregulated in patients with breast cancer compared to controls. There was no change in expression of miRNA-155 and miRNA-205 following surgery.

Conclusions:

The findings of the present study do not support the role of miRNA-155 and miRNA-205 as markers suitable for follow-up. However, the findings of the present study need to be confirmed in a larger sample size and samples collected over a defined post-operative period.
Successful outcome with outpatient acenocoumarol therapy for echocardiographically visible pulmonary thrombus
Authors: Gowrinath Karanam , Kamath K. Padmanabha
Published: July 2021

Visualisation of thrombus in the main pulmonary artery through two-dimensional transthoracic echocardiography (TTE) without cardiovascular instability is rare. We report a unique case of echocardiographically diagnosed acute pulmonary embolism (PE) in an ambulatory patient with concomitant cor pulmonale secondary to idiopathic interstitial lung disease. The mobile thrombus was first visualised at the junction of bifurcation of the pulmonary trunk with left pulmonary artery through routine two-dimensional TTE. Two days later, the contrast-enhanced computerised tomographic scan of the chest showed the thrombus to be in the distal portion of the right pulmonary artery. Complete resolution of pulmonary thrombus was achieved with a 3-month course of outpatient oral anticoagulation treatment with acenocoumarol without recurrence of PE during the 1-year follow-up.
Study of association of age at presentation with outcome in patients with head-and-neck cancer
Authors: Kesarwani Radha , Singh Astha , Singh Virendra , Prakash Gyan
Published: July 2021

Background:

Elderly patients with head-and-neck cancer (HNC) are increasing in number. Outcome of HNC with relation to age is controversial.

Methods:

In this hospital-based retrospective study, medical records of 76 patients of HNC who were treated with surgery followed by radiotherapy or radiotherapy with or without chemotherapy were analysed. The patients were divided into two age groups: Group I patients ≥55 years and Group II patients <55 years. Patient characteristics, treatment and toxicities were evaluated. They were followed-up clinically and radiologically up to a median time of 16 months.

Results:

Complete response was 94.4% and 80.05% in Group I and II, respectively. Disease-free survival (DFS) was 53.67% and 47.8% in Group I and II, respectively (P = 0.332), whereas overall survival (OS) was 67.34% and 49.42% in two groups, respectively (P = 0.234); hence, DFS and OS are not statistically significant.

Conclusion:

Complete response was more frequently among patients older than 55 years in comparison to patients younger than 55 years, even though the dose delivered to them is lower. There was no statistically significant difference in both groups with respect to DFS and OS. Haematological toxicities were found more in older patients in comparison to patients younger than 55 years.
Clinical and laboratory profile of tuberculosis in HIV-positive patients and occurrence of tuberculosis-associated immune reconstitution inflammatory syndrome
Authors: Subbalaxmi M. V. S. , Guduru Sravanthi , Kapoor Anu , Chandra Naval
Published: July 2021

Background:

Tuberculosis (TB) is the most common opportunistic disease in human immunodeficiency virus (HIV)-positive persons.

Methods:

We prospectively studied the clinical, radiological, cytological, histopathological and microbiological presentation of TB in HIV-positive patients and occurrence of immune reconstitution inflammatory syndrome (IRIS) in HIV TB co-infected patients.

Results:

Out of 70 patients studied, 47 were male. Fever was the most common symptom (n = 61, 87.1%). The most common laboratory finding was anaemia (n = 67, 95.7%). In 32 (45.7%) patients presenting with TB, HIV infection was diagnosed. A CD4+ count <200/mm3 was seen in 57 (81.4%) patients. Extra-pulmonary TB (44.3%) was more common than pulmonary TB. All patients were started on anti-TB treatment; 6 had developed IRIS.

Conclusions:

Our observations suggest that screening all HIV-seropositive patients for TB and careful monitoring for the occurrence of IRIS while on anti-TB treatment are helpful in managing HIV HIV-TB co-infected patients.
Membranous nephropathy and malignancy
Authors: Khelgi Vinod , Stack Paul , Venuthurupalli Sree Krishna
Published: July 2021

Background:

There is variable association of membranous nephropathy (MN) with malignancy predominantly of solid organ tumours. There is debate as to how to screen and or investigate for evidence of malignancy in this group.

Methods:

Retrospective analysis of kidney biopsies performed between 2006 and 2016. Patients with MN were identified and clinical course including age, degree of proteinuria, histology details, treatment and rates of remission documented. Evidence of malignancy and its temporal association with MN noted.

Results:

Over ten-year period 216 biopsies were performed of which 20 patients (10.8%) had MN [mean age 48.5 years (range 20-82 years); there were to males]. Of these, eight patients (40%) had evidence of malignancy. Four patients were diagnosed with malignancy prior to the biopsy (mean duration 39.7 months) whereas, 4 patients were diagnosed after the biopsy (mean duration 6.7 months). Patients with MN and malignancy were older compared to those without malignancy (63.0 Vs 38.2 years) (P = 0.0054). There was no statistical difference in degree of proteinuria, focal segmental glomerulosclerosis lesions, and number of inflammatory cells in the study population.

Conclusions:

Higher prevalence (40%) of malignancy was associated with biopsy proven MN from Darling Downs which was statistically significant. Although age appropriate investigations are indicated in these patients, it may be prudent to actively look for evidence of underlying malignancy especially in elderly population given the concerns associated with immunosuppressive therapies.
Systematic Literature Review: The Effectiveness of giving Cinnamon (Cinnamon) on Reducing the Intensity of Menstrual Pain (Dysmenorrhea)
Authors: Kusumaningtyas Dian , Kusumaningtyas Dian , Kusumaningtyas Dian
Published: July 2021

Every woman experiences menstruation, which is the process of releasing blood, mucus, and cell debris from the dissertation of the uterine mucosa by removing the endometrium (desquamation) periodically and cyclically. It begins about 14 days after ovulation. Sometimes menstruation causes pain (primary dysmenorrhea) during menstruation. Primary dysmenorrhea can be reduced with natural ingredients, one of which is cinnamon, which has the main compounds cinnamaldehyde and eugenol as anti-inflammatory and antispasmodic. This study aimed to determine the effectiveness of cinnamon in reducing the intensity of menstrual pain (dysmenorrhea). The method used Systematic Literature Review or SLR to analyze articles from some databases The results showed that eight from ten studies were researched with the intervention group (cinnamon) and two journals were descriptive studies. Eight cinnamon intervention groups, three used pills, two used aromatherapy massage, one used cinnamon tea, one used cinnamon extract, and one did not explain the method. All journals show that cinnamon is effective for reducing the intensity of dysmenorrhea.
A gestão pedagógica face “ao termômetro” da qualidade educacional: o ideb como modelador de práticas educacionais
Authors: Silva Simone da Costa , Diógenes Elione Maria Nogueira , Da Silva Costa Maria Cledilma Ferreira
Published: July 2021

Este trabalho apresenta um recorte dos resultados de uma pesquisa de mestrado que buscou analisar como o IDEB vem interferindo na gestão pedagógica escolar, visto que, esse índice, como um instrumento de controle da qualidade educacional, pode torna-se um modelador de práticas educativas. Na busca por compreender a problemática elencada, tomou-se uma metodologia comparativa com base nas orientações qualitativas de pesquisa, analisando-se duas escolas, uma com indicador elevado e outra com o índice baixo. Além da observação nessas instituições, realizou-se entrevistas com coordenadores e professores, em que suas falas foram analisadas com base na técnica de análise do conteúdo. Os dados levantados confirmam que o IDEB, em formatos diferentes, vem modelando as ações dessas escolas.
Marx: o ser e o fazer história
Authors: Diógenes Elione Maria Nogueira , Costa Maria Cledilma Ferreira da Silva
Published: July 2021

Trata de uma abordagem teórica acerca de um texto clássico de Karl Marx (1818-1883), a saber: “Introdução ao método da economia política” (1982). O artigo ganha um contorno narrativo e vai tecendo um argumento a favor das teses marxistas. A ideia é demonstrar a atualidade do pensamento marxista para pensar os problemas do mundo contemporâneo. Conclui-se que o referido texto de Marx é um clássico e como tal deve ser compreendido.
Um estudo sobre os possíveis contatos envolvendo alunos em salas de aulas
Authors: Da Silva Severino Horácio , Da Silva Michelli Karinne Barros
Published: July 2021

No início da pandemia da COVID-19 as escolas brasileiras foram fechadas com o objetivo de conter a disseminação do vírus. Diante da discussão sobre a reabertura das escolas, neste trabalho, consideramos alguns cenários típicos de salas de aulas e através de um cálculo combinatório deduzimos o número de pessoas que cada aluno estaria exposto, bem como o número de possíveis contatos cruzados entre cada aluno e as pessoas expostas. Os cenários considerados foram ilustrados por figuras construídas no software de geometria dinâmica GeoGebra, onde as pessoas são representadas por vértices de polígonos e os contatos cruzados entre as pessoas pelas diagonais desses polígonos. Acreditamos que as informações referentes a contatos sejam relevantes, em momentos de pandemia, uma vez que os contatos potencializam o contágio.
Importância dos mecanismos de investimento para implantação de novos negócios: um estudo ao redor do arco metropolitano
Authors: De Freitas Rodrigo Rodrigues , Gonçalves Diego Manoel Enedino , Paiva Thiago de Souza Cardoso Mayrink
Published: July 2021

O trabalho realizado possui o propósito de aumentar as possibilidades na tomada de decisão, a luz de uma abordagem financeira em relação a implantação de terminais logísticos ao redor da BR 493/RJ - arco metropolitano. As oscilações e choques externos demandam uma abordagem probabilística, a fim de, flexibilizar a tomada de decisão e mitigar o risco inerente a projetos expostos a volatilidade de mercado. A aplicação do modelo de Black & Scholes em opções reais possibilita a absorção de choques externos e mitigação do risco inerente a precificação do ativo analisado. Confrontando o modelo anterior, utilizamos o modelo de Geske ajustado por Kemna para opções composta. Observando que ambas são opções europeias e possuem duas possibilidades de investimento inicial para a tomada de decisão.
Explore In Teaching Using Data-Mining Technique
Authors: Sharma Ravi Kumar , Brar Tejinder Pal Singh
Published: July 2021

iAs ian iinterdisciplinary iorder, iinformation imining i(DM) iis ifamous iin itraining iterritory iparticularly iwhile iinspecting iunderstudies' ilearning iexhibitions. iIt icenters ion ibreaking idown iinstructive irelated iinformation ito icreate imodels ifor iimproving istudents' ilearning iencounters iand iupgrading iinstitutional iadequacy. iSubsequently, iDM ihelps ischooling iorganizations igive itop inotch itraining ito iits istudents. iApplying iinformation imining iin itraining iotherwise icalled iinstructive iinformation imining i(EDM), iwhich iempowers ito imore ireadily isee ihow iunderstudies ilearn iand irecognize ihow iimprove iinstructive iresults. iPresent ipaper iis iintended ito ilegitimize ithe icapacities iof iinformation imining iapproaches iin ithe irecorded iof itraining. iThe imost irecent ipatterns ion iEDM iresearch iare ipresented iin ithis isurvey. iA ifew iexplicit icalculations, istrategies, iapplications iand iholes iin ithe icurrent iwriting iand ifuture iexperiences iare italked iabout ihere.
Isolation and Screening of Pectinase Producing Bacteria from Soil Sample
Authors: - Shilpa , Kaur Mandheer , Jadon Yogita
Published: July 2021

The vast majority of the industrial use of enzymes is covered from microorganisms. Microorganisms are favoured in industry because of their several advantages for example rapid growth, short life expectancy and simplicity in doing genetic alterations. Microbial enzymes are thus amply provided, very much standardized and promoted by many companies. Among various enzymes, Pectinases hold an exceptional place because of its different uses in various sectors like food, textile and biofuel industries.A total of 25% of total enzyme market is being shared by Pectinase alone.The current study was carried out to evaluate the pectinase activity of the pectinolytic bacteria. 40 Bacterial strains were isolated from different soil samples and screened for Pectinase production. Primary and Secondary screening showed 3 potential isolates I38 , I39 and I40 showing pectin degradation on Vincent’s media. Further, extracellular pectinase was partially purified by ammonium sulphate precipitation and dialysis. Sequential ammonium sulphate saturations from 20-80% i.e. (20, 40, 60 and 80%) showed 60% ammonium sulphate was optimum for precipitation of intracellular enzyme whereas 80% was optimum for extracellular enzyme.
Blood Group Susceptibility towardsCOVID-19 and Other Diseases
Authors: Sharma Renuka , Kaur Manpreet , Kaur Manpreet , - Neeru , Yadav Neha , Kaur Parminder , Kaur Sarbjeet
Published: July 2021

COVID – 19 is a global pandemic caused by a coronavirus named SARS CoV -2. A large family of viruses that causes severe respiratory diseases known as Coronavirus (CoVs) show symptoms such as common cold and range to more rare and severe respiratory diseases such SARAS i.e Severe Acute Respiratory Syndrome and MERS i.e Middle East Respiratory Syndrome detected for the first time in 2003 and 2012, respectively. It is expected to be a zoonotic virus transmitted via bats categorically, from genus Rhinolophus and closely related animals to humans. As this life threatening pandemic started from the Wuhan city of China, and the examination about this disease is still in continuity. It is very important to explore all possible scientific key points regarding this disease to eradicate such a dangerous issue from the society and to save the human race on earth. Literature available till now confirmed that the ABO blood group system showed significant relationship with various diseases. Now, scientific communities were working on different aspects of COVID-19 disease. But by keeping in mind about the severity of this disease and the relationship of blood group system of humans with infectious disease we conducted this study. Present review is designed to explore the relationship of COVID-19 alongwith other disease with the ABO blood group and Von Willebrand Factor. This study will provide information about the scientific evidences regarding the role of blood group antigens in prognosis of COVID-19 alongwith other disease and this can be significant for future research.
Micro-plastics: An invisible danger to human health
Authors: Sharma Renuka , Kaushik Himanshi
Published: July 2021

Microplastics are small plastic pieces ranging between the size of 1-5 micrometre (µm). Because of their small size and their continuity, it has the potential to spread throughout all parts of our environment. These are ubiquitous environmental contaminants leading to inevitable human exposure. It can enter our bodies through ingestion, inhalation and dermal contact. It has already been found in various human foods, beers, drinking water, honey, seafood, sugar, table salt etc. It is demonstrated that marine organisms including zooplanktons, bivalves, crustaceans, worms, fish, reptiles etc. ingest microplastic. Around 2% to 40% of fishes were found to be contaminated with microplastic. It can reach our stomach and due to its size , these are either excreted, get entrapped in intestinal lining and stomach or move freely in body fluids like blood, thereby reaching various organs and tissues of body. To tackle this serious issue of microplastic pollution in environment and in human health, various effective policies must take under consideration all stages of lifecycle of plastic connecting producers to users and ultimately to waste managers. Thus, we have to seem for potential effects of microplastics in living beings, which specializes in the pathways of toxicity and exposure, way to reduce microplastic pollution, sources of invisible plastics. Present work was conducted to explore the possible threats of micro as well as nanoplastic particles to humanity as well as to our ecosystem. Under this study we summarized various aspects of this critical issue, which provide better scientific knowledge for future research.
Amylase Based Clarification of Apple, Orange and Grape Juice
Authors: Sondhi Sonica , Kaur Palki Sahib , Sura Himansi , Juglani Manisha , Sharma Deepali
Published: July 2021

Amylases are starch-degrading enzymes produced by many bacteria, plants, fungi and animals. It has found tremendous application in industry. One of its applications is in fruit industry wherein amylases are used to clarify fruit juices and reduce its viscosity. In fruits, high amount of starch is present which resulted in increased viscosity of the prepared juices. This may also lead to settling of juice at bottom. Amylases act on starch component and degrade it. In the current study, amylase from B. licheniformis was used for the clarification of apple, orange and grape juices. Total suspended solids, viscosity and total acidity was found to decrease with increasing amylase concentration. The results revealed that after amylase treatment the color, texture and flavor of juices were also improved.
Microorganisms as vital additives in Waste Management
Authors: Sharma Renuka , Gupta Khushboo
Published: July 2021

Microorganisms play necessary roles within the maintenance of the many natural and synthetic development within the environment. They serve positive functions that build life easier and higher for man. one in every of such areas that microorganism’s area unit adopted is in waste management. the right disposal of the voluminous waste that humans generate in their daily activities may be a nice challenge that government and environmental agencies area unit unceasingly seeking higher ways that of addressing. a crucial method of with success combating this menace is thru the utilization of microorganisms. Thus, this paper examines the varied applications of microorganisms within the management of municipal waste. It reviews the varied roles of microorganisms within the atmosphere, like in waste product and soil treatment, energy generation, oil spillage and hot contamination. It conjointly discusses waste generation and management ways, and a few specific uses of microorganisms (bacteria, fungi, algae, virus and protozoa) in waste management. It concludes by light some recent advances in microbiological waste management.
A Review on Different Regression Techniques and its applications used in Machine Learning
Authors: Kaur Anmol , Kaur Jaspreet , Kaur Maninder
Published: July 2021

Regression Analysis is an assortment of factual methods that fill in as an explanation behind drawing acceptances about associations among the various interrelated elements. This technique is pretty much applicable in almost everywhere in study field which includes biological sciences, social studies and relapse examination. The main purpose of this research paper is to evolve the vital hypothesis for the factual Regression Technique and also to demonstrate the hypothesis with a collection of wide variety of various models looked over economical aspects, demography, sketching and engineering concepts. To assemble the relevant content which is independent from various insights, mathematics based on variable and numerical investigation is included.
Sonoelastography in differential diagnosis of pathological processes of the myometrium (literature review)
Authors: Sharmazanova О.P. , Safonova I.N. , Mitiakova Y. S.
Published: July 2021

Background. Intrauterine pathological processes, the most common medical conditions of which are leiomyoma, adenomyosis and infiltrative adenocarci- noma, currently represent a quite prevailing group of gynecological pathology, dangerous due to the potential of malignancy and recurrence. The development of an integrated non-invasive diagnostic approach that takes into account risk factors, symptoms, clinical examination and imaging, makes it possible to make an accurate diagnosis, which is essential to determine therapeutic strategy. Рurpose – to carry out a systematic analysis of the uptodate scientific literature regarding the use of imaging methods in diagnosis of pathological processes of the myometrium and determine the main directions of their development in these pathologies. Materials and methods. The material for the study were publications and results of clinical trials found in Scopus, Web of Science Core Collection and PubMed databases for the period from 2013 to 2020 based on the keywords like “adeno- myosis”, “leiomyoma”, “adenocarcinoma”, “sonography”, “sonoelastography”. Results and discussion. The complexity of diagnosing myometrial neoplasms, especially in case of combinations, initiates the search for new algorithms for diagnosing pathological processes of the myometrium, the purpose of which, ultimately, is to determine personalized strategy of treatment of female patients. According to the literature, recently sonoelastography potential has been increasingly used in diagnosis of the reproductive system diseases and assessment of the functional state of uterine tissues, contributing to differential diagnosis, monitoring and treatment of these diseases. Conclusions. Thus, there is a limited number of studies on the diagnosis of myometrium pathology along with insufficient general standards of technique for conducting and interpreting the findings of sonoelastography in the reproductive system pathology. Adding sonoelastography data to sonographic images in B-mode is useful for differentiating leiomyoma, adenomyosis, and normal uterus, which is reflected in increased accuracy and diagnostic consistency. Sonoelastography potential consists in increasing the accuracy of diagnosis, safety and availability of the method, its low cost. This contributes to the possibility of wider implementation of the technique in clinical practice in order to obtain additional diagnostic information.
Peculiarities of communication of managing civil servants and the control area institutions in case of emergency at NPP
Authors: Prylypko V. A. , Petrychenko O. O. , Morozova M. M. , Bondarenko I. V.
Published: July 2021

Background. Implementing the measures to protect the control area (CA) population is ensured by Emergency Planning and Response System of “NNEGC” Energoatom” in case of accidents and emergencies at NPPs of Ukraine (EPR) as a part of the Unified State Civil Protection System (USCPS).

Purpose. Specifying the features of interaction between different management structures in the domain of radiation protection of the control area population in case of emergencies at nuclear power plants.

Materials and methods. The expert evaluation method was utilized in the research process. Five main groups of experts, responsible for the state of radiation protection of various population groups of South-Ukrainian NPP (SUNPP) control area and qualified according to the key criteria, have been formed. Semi-closed-ended and open-ended questions were used in the expert evaluations, a 5-point scale was used in closed-ended ones, and nominal ones were used for others. When processing, statistical methods designed to analyze non-numerical information were applied.

Results and discussion. In case of emergency at SUNPP, the system of alerting municipal authority executives of cities and rural settlements of the control area is “more or less” effective and can be achieved within 30 minutes. The control area population is provided with stable iodine agents, the population of Yuzhnoukrainsk is provided with individual protective gear in the best way; Voznesensk and rural settlements have a little lower levels of supply. The rural areas are characterized by the lowest level of first aid kits, protective clothing and respirators supplies. Implementing the measures to limit the consumption of food contaminated with radionuclides and to provide “clean” one, as well as to restrict the consumption of drinking water contaminated with radionuclides, and to provide “clean” one is about 3.0 points (“approximately 50% of what is needed”).

Conclusion. The analysis of expert evaluation data shows that the NPP and the State Emergency Service conduct regular training in case of emergency at NPP forming stereotypes of behavior of managing civil servants. The level of readiness to put protective measures in action in case of emergency at SUNPP varies, depending on the state service and institution as well the location of those ones in the control area. The level of readiness in the edge city is the highest; it is lower in cities and the lowest in the rural areas. The level of being equipped with key facilities is extremely low in civil protection services and primary healthcare units.
Electrochemical detoxification in cancer patients after multiorgan surgery with severe endogenous intoxication
Authors: Krutko Y. M. , Pylypenko S. O. , Pavliuchenko O. S.
Published: July 2021

Background. Enteral insufficiency syndrome accompanies the development of many acute diseases of the abdominal cavity. According to the statistics, advanced and multi-organ surgical intervention in oncosurgery within the period from 2019 to 2020 resulted in enteral insufficiency being a complication in 39% of all cases, regardless of anatomical and physiological area, while complications in the form of endogenous intoxication syndrome made up 68% of cases.

Purpose – studying the effectiveness of treatment of enteral insufficiency syndrome in cancer patients after multiorgan surgery with severe endogenous intoxication by means of indirect electrochemical detoxification with sodium hypochlorite solution.

Materials and methods. The study involved 71 cancer patients who underwent multi-organ surgery on different anatomical and physiological areas. The patients were divided into 2 groups: treatment group (n=36) provided with indirect electrochemical detoxification by means of sodium hypochlorite solution at a concentration of 0.06%, comparison group (n=35) undergoing treatment according to standard schemes. The groups were comparable in age and anatomical and physiological areas that were operated on (surgery was performed on the chest and mediastinum as well as abdominal organs).

Results. The method of electrochemical detoxification with sodium hypochlorite reducing the indicators that reflect blood toxicity and intoxication level was used for treating patients with enteral insufficiency. This was evidenced by decreased concentration of bilirubin by 23.1%, urea by 91.6%, creatinine by 99.4%, LII (leukocytal intoxication index) by 47.2% and procalcitonin by 68.2%. Being applied this method has made it possible to achieve a detoxifying effect early on day one.

Conclusions. The findings of complete physical examination of cancer patients after multiorgan surgery with severe endogenous intoxication have shown a practical significance of sodium hypochlorite being included in comprehensive post-surgery treatment in enteral insufficiency syndrome cases. Infusions of 0.06% NaClO solution within 24 hours have been proved to provide a detoxifying effect: they significantly reduce elevated concentrations of bilirubin, creatinine, urea, LII and improve blood rheology.

Administering sodium hypochlorite in the suppre-ssion of antioxidant defense mechanisms leads to the activation of oxidative processes.

Including sodium hypochlorite in comprehensive post-surgery treatment in enteric insufficiency syndrome has shown a high efficiency.
Study of the role of digital radiological examination in the diagnosis of lung changes in Coronavirus disease
Authors: Spuziak R. M. , Ulko R. V. , Maksimishyn O. V. , Stepanov E. P.
Published: July 2021

Introduction. World Health Organization announced that COVID-19 was a “public health emergency”. Тhe number of patients with COVID-19 and deaths from this disease are increasing every day, so the issue of diagnosis and treatment of this serious pathology remains relevant. Goal. To identify the key lung lesion patterns in patients with SARS-CoV-2 infection during digital radiological examination. To identify its capabilities in assessing the prevalence and dynamics of radiological manifestations of lung damage. Material and methods. The analysis of data of radiological examination of 1,075 patients with SARS-CoV-2 infection in moderate and severe conditions, who were treated in MNPE KRC “Regional Clinical Specialized Dispensary for Radiation Protection” in the period from June to November 2020 has been carried out. All the patients were given digital radiography at the time of treatment. To assess the dynamics the control examination depending on the clinical manifestations was held. The images were evaluated by two independent radio- logists. Pathological changes manifested in the form of matte, consolidation of parenchyma and reticular pattern. Results. The majority of the total number of the surveyed patients falls on the age group between 50 and 75 years old – 789 patients (73.4%). The most common pattern of lung lesion on the primary radiograph is a GGO symptom (82.7%), and in control examination there was an increase in the frequency of consolidation (53.4%), and then – fibrous changes of varying severity (62.5%). Bilateral lesion was detected in 74.8% of cases. Middle-lower and lower lobes of the lungs were more often affected. Conclusions. OCC CT should be used to detect pathological changes in COVID-19 in the early stages, and digital radiography can identify characteristic signs of lung lesion in inpatients with moderate to severe Coronavirus disease and is sufficient to assess the dynamics of the patholo- gical process. Digital radiography method should be included in the examination protocol of patients in moderate and severe conditions in the hospital due to the impossibility or difficulty of their transportation. If repeated examination in such patients is necessary much higher dose load on CT compared to digital radiography should be taken into account.
Diagnosis of cognitive function changes in patients with abdominal neoplasms occurring in the early postsurgery period and management of those with neuroprotective drug
Authors: Dubivska S. S. , Hryhorov Yu. B.
Published: July 2021

Background. The issue of analysis of diagnostic criteria and adequate neuroprotective management of postsurgery cognitive dysfunction in abdominal oncosurgery, depending on the degree and structure of disorders, remains unresolved, determining its relevance.

Purpose – assessing the postsurgery cognitive dysfunction in patients with neoplasms of the abdominal cavity and management of possible disorders with citicoline depending on the level of general cognitive deficit.

Materials and methods. TThe study was conducted at the premises of departments for patients of surgical profile of Municipal Institution “Kharkov City Clinical Hospital of Ambulance and Emergency Care named after Professor O.I. Meshchaninov”. To achieve the aim of the study, 80 patients with abdominal neoplasms who underwent surgery under general anesthesia using propofol and fentanyl were examined.

Results and discussion. Based on the comprehensive clinical study and anal- ysis of the mechanisms of formation of postsurgery cognitive dysfunction in patients of oncosurgical profile after surgery under general anesthesia, we suggested directions and schemes for managing postsurgery cognitive dysfunction by means of the developed clinical diagnostic criterion, which is essential in forming individual scheme of treating patients in postsurgery period.

Conclusions. Based on the analysis of data on the state of cognitive function changes, comparing the postsurgery period with the preoperative state, a differentiated approach to intensive neuroprotective therapy of postoperative cognitive dysfunction was developed. The technique of intensive neuroprotective   therapy   of   postsurgery   cognitive   dysfunction in patients with abdominal neoplasms, undergoing surgery under general anesthesia, was suggested.