bluuebunny/crossref_metadata_2025 huggingface dataset:
Alans and «Anti-Ottoman Coalition»
Authors: Tuallagov Alan A.
Published: October 2023

: The article is devoted to the problem of the supposed planning to attract the to the «anti-Ottoman coalition». Until recently, scientists have suggested that the Alans be seen as their various groupings, which objectively determines the scientific relevance of the proposed study. Verification of the proposed solutions is carried out on the basis of a textual analysis of the original written sources that directly covered those events. As a result of the study, the author came to certain conclusions. It should be recognized as a well-reasoned conclusion that the creation of the coalition was fictitious, and its «organizer» falsified letters to representatives of secular and spiritual authorities in Europe. The Alans do not directly appear in the information of written sources involved in the analysis. Researchers saw them in Arans (Arons) due to the ethno-geographical context presented in the sources, although the name, for example, can be corresponded to the name of Albania. Also, the ethno-geographic context determines the proposals to see in the Giths and Githiarans the Goths or Zikhs, Gothalans. Distortions of real ethnonyms may indicate the imperfect knowledge of the ethno-geographical realities of the Crimea and the Caucasus by the forger of letters, which is unacceptable for those on whose behalf the false letters were composed. But the falsification of letters in terms of mentioning these peoples did not pose a danger to their creator in the absence of the possibility of verifying information on the part of the addressees of the letters. On the other hand, it served as an indicator of the special achievements of the forger in «creating a coalition». He could also rely on some of the previous messages known to individual addressees of letters. The sources involved in the analysis do not give any grounds for statements about some dependence of the Alans on the kingdom of Kartli.
Comparative assessment of living conditions of the region's population
Authors: Bashirov Azat
Published: October 2023

The living conditions of the population are one of the para-meters that characterize the quality of life of the population. Based on the results of a comprehensive observation of living conditions conducted by Rosstat, a comparative assessment was made for the population of the Republic of Tatarstan. The comparative assessment of the region's indicators is due to the existing differentia-tion in the socio-economic development of the regions. As a result of the study, it was concluded that the housing conditions of households of the Republic of Tatarstan improved and that hous-ing provision and improvement were higher than the national average.
The implementation of Industry 4.0 concept in Smart City
Authors: Wolniak Radosław
Published: October 2023

Purpose: The purpose of this publication is to present relations between Industry 4.0 and Smart City. Design/methodology/approach: Critical literature analysis. Analysis of international literature from main databases and polish literature and legal acts connecting with researched topic. Findings: The study highlights the positive effects of Industry 4.0 on Smart Cities, including efficient infrastructure, connected transportation, data-driven decision-making, improved public services, and enhanced safety and security. Furthermore, Industry 4.0 supports sustainability, economic growth, and resilience in Smart Cities. However, implementing Industry 4.0 in Smart Cities poses challenges such as high costs, data security and privacy concerns, digital divide issues, workforce displacement, and technological complexity. Interoperability, energy consumption, lack of standardization, overreliance on technology, and resistance to change are also potential hurdles to be addressed. Originality/value: Detailed analysis of all subjects related to the problems connected with the smart city in Industry 4.0. Keywords: smart city, Industry 4.0, digitalization, sustainability, economy, public services. Category of the paper: literature review.
Platform Task Regaining the Next Generation of Archaeologists in Sri Lanka
Authors: Seneviratne Sudharshan
Published: October 2023

Commentary advocating for professionalism in Sri Lankan archaeology.
LIDERANÇA POSITIVA: CONCEITOS E PRÁTICAS PARA FOMENTAR O ENGAJAMENTO DOS LIDERADOS E POTENCIALIZAR RESULTADOS
Authors: Almeida Priscila Barros de
Published: October 2023

A liderança tem um papel essencial em todas as esferas da vida humana, interferindo diretamente no sucesso (ou insucesso) de uma organização. Os desafios na liderança ocorrem não apenas no ambiente corporativo, mas também no ambiente familiar (pais educando filhos), nas comunidades (líderes comunitários enfrentando desafios para impulsionar membros de sua comunidade local), ambiente acadêmico (docentes e líderes estudantis), nas forças armadas e em todas as organizações.
Neste cenário, a Liderança Positiva apresenta princípios, conceitos, técnicas e práticas que, quando bem aplicadas, alavancam o desempenho individual e coletivo levando pessoas e organizações a melhorarem seus resultados em curto, médio e longo prazos.
Training the next generation of Biostatisticians in West Africa: The Vanderbilt Nigeria Biostatistics Training Program (VN-BioStat)
Authors: Shepherd Bryan E. , Hussaini Nafiu N. , Ingles Donna J. , van Wyk Chelsea , Cassell Holly M. , Wester C. William , Aliyu Muktar H
Published: October 2023

Biomedical HIV research is growing in West Africa, but biostatistical expertise is lagging. The Vanderbilt-Nigeria Biostatistics Training Program (VN-BioStat) seeks to establish a research and training platform for biostatisticians doing HIV-related research in Nigeria. The objectives of the program are: (i) Host two Nigerian data scientists per year (a total of 10 over 5 years) at Vanderbilt University Medical Center to gain hands-on biostatistics training and experience via one-year fellowships. Eligible trainees will be junior investigators with PhDs or nearing completion of their PhDs in statistics or related fields, including mathematics and computer science. (ii) Conduct annual workshops in Nigeria to provide biostatistics training. Trainees will undertake biostatistics coursework and hands-on training and participate in mentorship as biostatisticians involved in HIV research. Trainees will be at Vanderbilt for a full year and be part of an active biostatistics department. They will be immersed in a dry-lab HIV biostatistics project in collaboration with a Nigerian HIV research project and lead a methodologically focused research project. They will also participate in a one-month research training/grant writing program in Nashville. The VN-BioStat program will build on the existing momentum of ongoing initiatives to enhance research capacity in Nigeria by developing biostatistics leadership. VN-BioStat trainees will interact with investigators from Nigeria to provide collaborative biostatistical assistance with study design and data analysis, thus gaining real-world experience that will benefit the trainees and the broader research community in Nigeria.
Rantai Nilai, Corporate Farming Dan Nilai Tambah Komoditas Kopi Kabupaten Temanggung
Authors: Matruty Eko Suseno HR , Widodo Arief , Damayanti Theresia Woro , Supramono Supramono
Published: October 2023

D

Research aim: To analyze the coffee commodity value chain and (b) to analyze the opportunities and challenges of implementing coffee commodity corporate farming in Temanggung Regency

Design/Methode/Approach: Data were obtained through interviews with several farmers, direct observations in the field, and FGDs involving the Temanggung Regency government apparatus related to the development of coffee commodities. Data are analyzed in narrative form, value chain analysis, and corporate farming model

Research Finding: The study results show that the coffee commodity value chain in Temanggung Regency consists of input, production, collection, processing, and marketing or distribution to consumers. Each of these chains has its problems, from the smooth supply of inputs and production prices,  ​​land ownership, and picking/harvesting coffee cherries that do not meet quality standards to coffee marketing. From the results of the FGD, it was also revealed that corporate farming has the opportunity to be applied to deal with the problem of coffee commodities so that it is expected to create higher added value which will be enjoyed by the farmers of Temanggung Regency

Theoretical contribution/Originality: This study integrates value chain analysis with the corporate farming model, which has not been the concern of previous researchers

Practitioner/Policy implication: This study offers policy proposals to the Temanggung Regional Government regarding the formation of corporate farming so that it can run effectively

Research limitation:  Not yet analyzed based on a quantitative approach, especially related to feasibility aspects.
NTRK-fusion detection in thyroid and salivary gland cancer offers a targeted therapy with NTRK-inhibitor
Authors: Hana Evangelin Prayogo  , Willy Sandhika
Published: October 2023

NTRK-fusion in cancer is rare but it offers targeted therapy with NTRK-inhibitor. NTRK fusion is not a point mutation. NTRK fusion is an oncogenic driver, NTRK mutation is not an oncogenic driver. Patients with NTRK point mutation do not respond to NTRK-targeted therapy. NTRK fusion was detected in secretory carcinoma. Secretory carcinoma was a new entity, first described in 2010, classified by NTRK-fusion. It is often misdiagnosed, and standard pathology often fails to distinguish it from another histology subtype of salivary gland carcinoma, so its frequency can be higher than has been reported. Therefore, different examinations are needed in order to obtain a correct diagnosis. In thyroid gland carcinoma, NTRK fusion-positive carcinomas are associated with clinically aggressive disease with a high metastatic rate. Therefore NTRK-fusion test should be performed in thyroid cancer patients with recurrence and unresectable disease, metastatic thyroid cancer, Radioactive Iodine (RAI)-refractory disease, and invasive disease. Immunohistochemistry with antibody against TRKA, TRKB, and TRKC can be used to identify TRK protein expression in salivary gland cancer so this test can be used for screening in all salivary gland cancers. NGS or FISH are tools that can be used to confirm NTRK fusion. Detection of NTRK fusion allows new hope for cancer patients with refractory therapy.
A review on compaction and loosening of agricultural soils
Authors: Abisuwa T. A  , Agbetoye L. A. S  , Soyoye B. O  , Ewetumo T
Published: October 2023

Many soil experts and farmers are very concerned about the hard soil layers of agricultural soils. A layer known as hard soil is created when soil is compacted repeatedly over a long period of time. A type of physical soil degradation known as soil hardening modifies soil structure, restricts air and water penetration, and lessens root encroachment. These effects on the crust of the earth are still not fully understood. Therefore, to solve the worldwide dilemma of future food security, a thorough understanding of the subsurface processes is required. Compaction research must also be taken seriously because climatic conditions are shifting as a result of climate change, opening the door for the creation of novel mechanical tillers that can address compression problems. As a result, the focus of this study is on investigating the type, traits, causes, and effects of soil compaction on agricultural production as well as potential remedies using soil tillage.
A comprehensive review of electric vehicle charging infrastructure and associated challenges
Authors: Nikita Omase  , Shailendra Kumar Mittal  , Shenbagalakshmi Palaniraja  , Pabitra Guchhait  , Manjusha Patil  , Prateek Mundra
Published: October 2023

Electric vehicles (EVs) have emerged as a sustainable and eco-friendly opportunity to standard internal combustion engine automobiles, with the potential to significantly reduce greenhouse gasoline emissions and dependence on fossil fuels. However, the considerable adoption of EVs is contingent upon the development of efficient and on hand charging infrastructure. This research paper provides a complete evaluation of electric automobile charging techniques, aiming to offer a holistic knowledge of the contemporary country of EV charging technology, demanding situations, and future potentialities. This research delves into the important thing technical issues associated with EV charging, consisting of strength output, voltage, current, and connector requirements. Furthermore, the evaluation addresses crucial challenges hindering the giant adoption of EVs, inclusive of range anxiety, grid integration, and the need for standardization.
Decolonizing African science: Efforts, challenges, and future directions
Authors: Elvis Fon Tata  , Kenneth Anchang Yongabi  , Ernest Dzelamonyuy  , Noela Ijang Forbang  , Edi Achuh Geh
Published: October 2023

Colonial legacies have deeply shaped Africa's scientific and educational realms, imposing Western knowledge systems while marginalizing indigenous wisdom. The journey of decolonizing African science involves a profound recognition of this historical bias and the endeavor to restore indigenous knowledge to its rightful place. This article explores contemporary efforts, challenges, and future directions within this crucial mission. Contemporary Africa is witnessing a resurgence of interest in its indigenous knowledge systems, spanning agriculture, medicine, environment, and culture. Curriculum reforms are underway, aiming to weave indigenous knowledge into the educational fabric, nurturing cultural relevance. Indigenous knowledge centers have sprung up to systematically study and promote traditional wisdom. Language revival initiatives are bridging linguistic gaps, democratizing access to knowledge. Yet, formidable challenges persist, including limited resources, language barriers, resistance to change, and the hierarchical dominance of Western academia. International collaboration, community engagement, and ethical considerations remain pivotal. As Africa forges ahead in decolonizing its science and education, it paves the way for a harmonious coexistence of diverse knowledge systems, fostering innovation and empowerment.
Risk factors for the incidence of low-birth-weight babies in Indonesia: A literature review
Authors: Ardania Yulian Putri
Published: October 2023

Low Birth Weight (LBW) is a critical issue in Indonesia, affecting 5-10% of newborns and contributing significantly to infant mortality. The primary risk factors include multiple pregnancies, maternal anemia, and insufficient maternal energy intake. The aim of this research is to identify the factors influencing the occurrence of low birth weight in Indonesia. The research method utilized is a literature review, which involves searching for research articles from the electronic database Google Scholar using keywords such as Low Birth Weight, causal factors, anemia, nutritional status, and maternal factors. From the research findings, it can be concluded that the occurrence of LBW is caused by risk factors such as anemia (3 articles), preeclampsia (3 articles), maternal age (3 articles), and chronic energy deficiency (1 article). Overall, understanding these factors is crucial for improving efforts to prevent LBW and enhancing the health of both mothers and infants during pregnancy.
Regulatory requirements for approval of biological products as per CDSCO in Indian comparison with South Korea
Authors: Ashok kumar P  , Divija P M  , Reshma B R  , Bhoomika K R  , Ramya Shree R
Published: October 2023

Biologicals are restorative, therapeutic, analytic, preventive, arrangements created or got from living life forms and their turn for human use. Biological products are expected to continue to play a significant role in the future of medicine and health care. They include vaccines, serum, blood and blood products, gene therapy, antibodies, etc. The Indian administrative expert (CDSCO), is the body which is in charge of the advancement and promoting biologics in India. And in South Korea MFDS is responsible for regulations of biologics. Objective: Unveiling the differences in regulatory approval aspects and documentation for biological products in India and South Korea as per CDSCO and MFDS respectively. Ensuring the safety, effectiveness, and quality of biological products requires various regulatory processes. These processes typically include rigorous testing, clinical Trails, quality control measure, and regulatory approvals by agencies like CDSCO in India and MFDS in South Korea. These steps are decisive to protect public health and ensure the biological products meet established standards before they made available to patients.
Effect of individual factors on the extraction of phenolic compounds from turmeric rhizomes (Curcuma longa) and moringa leaves (Moringa oleifera
Authors: Bosson Jean-Aimé ASSANVO  , William Kwithony DISSEKA  , Yves DJINA  , Martin Luthère King N’GBO  , Koué Stéphanie Vianney DAYORO  , Meuwiah Betty FAULET-AHONZO
Published: October 2023

Phenolic compounds are of great interest for their high antioxidant power and their numerous health benefits. These biomolecules are present in large quantities in many food and medicinal plants, such as the rhizomes of Curcuma longa and the leaves of Moringa oleifera. However, extraction methods for these bioactive compounds underestimate the plant's potential. The aim of this study was therefore to evaluate the influence of seven factors involved in the process of extracting phenolic compounds from Curcuma longa rhizomes and Moringa oleifera leaves. The seven main factors, i.e. drying time, mesh size, ethanol concentration, solvent/sample ratio, stirring speed, temperature and extraction time, influence the extraction of total polyphenols from Curcuma longa rhizomes and Moringa oleifera leaves. However, the optimum conditions for sample drying time are 48 to 72 h for Curcuma longa rhizomes and 60 to 72 h for Moringa oleifera leaves. Those for mesh size and sample/solvent ratio are 250 to 500 µm and 1/20 to 1/10 respectively. The best solvent concentration was between 60 and 80% for Curcuma longa rhizomes and between 40 and 60% for Moringa oleifera leaves. In addition, the best stirring speed is between 200 and 300 rpm and the best extraction time between 15 and 30 min. In addition, the best extraction temperatures are between 40 and 50°C for Curcuma longa rhizomes and between 50 and 60°C for Moringa oleifera leaves. These factors should therefore be taken into account for maximum extraction of total polyphenols from Curcuma longa rhizomes and Moringa oleifera leaves.
Digital transformation of tax in academic research: A literature review
Authors: Vu Thi Lan Huong  , Nguyen Thi Tuyet Van  , Vu Thi Thanh Huyen
Published: October 2023

This study aims to systematize previous research on digital transformation in the tax industry, make statistics, and evaluate according to the most influential authors in research on digital transformation in the tax industry. Research data was collected and analyzed from the Google Scholar database on VOSviewer 1.16.19 software with 76 articles for the keyword "digital transformation in the tax industry" filtered in abstract and title form. The results show that research on digital transformation in the tax industry has gradually increased since 2014 and the number peaked in 2021 (20 articles). The study also shows the most influential authors according to the number of citations and number of articles, the keywords of most interest in digital transformation research in the tax industry. The research results have contributed to synthesizing a system of research documents on digital transformation in the tax industry. At the same time, keyword analysis identified much content that will be important research points for future research.
Anti-Alzheimer potential of coumarin derivatives: A review
Authors: Vishesh Verma  , Nitin Kumar  , Sumit Kumar
Published: October 2023

Alzheimer’s is a type of neurodegenerative diseases (NDs) found in old age people which main causes the dementia and various brain disorders. FDA approved drugs used commonly in treatment of moderate to severe Alzheimer's disease are Donepezil, Rivastigmine, Galantamine and Memantine. However, these approved drugs provide only palliative support not complete cure. So, urgency of new molecules has been becoming so important to cure this complex Disease. Coumarin or 2-H-Chromen-2-one is an oxygenated heterocyclic compound, which is isolated from plants named Dipteryx odorata Willd, (Fabaceae). Synthetic coumarin derivatives has been well presence in literature due to existence of their potential pharmacological activities in literature. This review covers the anti-Alzheimer activities of chemically synthesized coumarin derivatives from 2016-2023. Coumarin derivatives profound found exhibits potential anti-Alzheimer activities in literature. Coumarin derivatives showed their anti-Alzheimer potential through various pharmacological pathways such as monoamine oxidase (MAO) inhibitor, acetylcholinesterase (AChE) & Butyl cholinesterase (BuChE) inhibitory activity, Aβ amyloid inhibition, Beta secretase 1 (BACE1 inhibitors). Multi-target directed ligands (MTDLs) approach also extensively reported to design and synthesis of novel coumarin scaffold as potential multifunctional Anti-Alzheimer activities in last one decade. We also covered literature of some coumarin hybrids derivatives as potential Anti-Alzheimer activities. Some common synthetic methods of coumarin structure also covered in this review article. This review supported that coumarin derivatives found excellent anti-Alzheimer activities and it can be play major role to solve the problem of complex AD disease.
Homestead mechanized aquaculture in Bangladesh: New concept for enhancement for production and profitability
Authors: Mithun Roy  , Aklima Akhter  , Md. Asadujjaman  , Tanmi Shahrin  , AKM Shafiul Azam  , Muhammad Tanvir Hossain Chowdhury
Published: October 2023

In Bangladesh, almost all of the homestead ponds are cultured extensively, where there are scopes to enhance productivity through aquaculture mechanization. Five household-sized ponds (60±0.02 decimal) were selected. No mechanization is done on Pond 1. Pond 2, Pond 3, Pond 4 and Pond 5 were equipped with surface aeration; Pond 3 was with Bottom aeration; Pond 4 and Pond 5 were equipped respectively with surface, bottom, combination of both and combination of both aerations along with additional automated feed sprayer. All ponds were stocked at a rate of 250 pcs. /decimal mono-sex Tilapia (Oreochromis niloticus) and the stocking size was 0.90±0.15 g. Water Temperature, pH, and dissolved oxygen (DO) were recorded two times daily, whereas Ammonia, Nitrate, Nitrite and Phosphate data were recorded fortnightly during the 124-day culture period. Highest average growth (266.08±12.80 g) and lowest Feed Conversion Ratio (1.10) were found in Pond 5, whereas the lowest average growth (153.70±48.07) and highest FCR (1.70) was found in Pond 1. Production was enhanced by 40%, 28%, 47% and 54% respectively in Pond 2, 3, 4 and 5; compared with the control Pond 1. Economic analysis showed that the profit increased by 13%, 25% and 41% in Pond 2, 4 and 5 respectively compared with control Pond 1. In Pond 3, profit decreased by 25% compared with control Pond 1. In all treatments, FCR is reduced, which is very important to maintain good water quality for homestead ponds. Economically These experiments need to be further developed for polyculture ponds, to find out the appropriate species combination, to serve partial harvest for household consumption and for more viable economic return.
Sexuality of women with mobility impairments
Authors: Dimitra Metallinou  , Agathi Exarchou  , Katerina Lykeridou  , Antigoni Sarantaki
Published: October 2023

Sexuality is a complex and personal aspect of a woman's life and it is not determined by mobility abilities or disabilities. Women with mobility impairments, like anyone else, have diverse interests and orientations when it comes to their sexuality, and undoubtedly have needs for intimacy and relationships. However, there can be unique challenges that these women may face. These challenges can include physical barriers, lack of accessibility, and societal attitudes. Some women with mobility impairments may require adaptive equipment or techniques to engage in sexual activities comfortably and safely. It is important to acknowledge and respect their desires and preferences and ensure that their sexual rights and autonomy are upheld. Support and open communication are essential for women with mobility impairments to have fulfilling and satisfying sexual lives. This includes discussing desires, boundaries, and any necessary accommodations with partners and healthcare professionals. Additionally, educating society about the importance of inclusivity, accessibility, and respectful attitudes towards women with disabilities is crucial. By promoting research, education, and inclusive sexual healthcare services, healthcare providers can empower these women to explore and embrace their sexuality, leading to enhanced quality of life and overall well-being.
Characterization of sperm cells in infertile male subjects in southwest Nigeria
Authors: Oni Emmanuel Sunday  , Ebirien-Agana Samuel Bartimaeus  , Edna Ogechi Nwachuku  , Elekima Ibioku  , Thankgod Prince Ohaka  , Wojuade Samuel Kehinde
Published: October 2023

Sperm characteristics are used as proxy to estimate or gain insight into the underlying causes of male infertility. The aim of the study was to characterize sperm cells in infertile males in South-West Nigeria. This is a cross-sectional study involving 92 male subjects, grouped as 35 fertile males (control) and 57 infertile males (test subjects). The subjects, who volunteered, were attendees of Fertility Clinics in Lagos Metropolis, Lagos, Nigeria. Semen specimens were collected and analyzed with computer-assisted sperm analyzer (CASA) in conjunction with WHO guidelines for semen preparation and examination. Raw data obtained from the measurements, were subjected to statistical analysis using GraphPad Prism Version 5.03 (San Diego, California, USA). Results were expressed as percentage. The results revealed sperm cells in the infertile subjects as following: (a) based on sperm counts; the sperm cells were oligospermia and azoospermia with prevalence of 54 (79%) and 12 (21%) respectively. (b) Based on sperm cell morphology: the sperm cells were 14 (25%) oligoasthenoteratospermia, 12 (21%) teratospermia, 9 (16%) oligoasthenospermia; 9 (16%) oligoteratospermia, 5 (8%) asthenospermia, 4 (7%) asthenoteratospermia and 4 (7%). Cryptospermia. (c) Based on ejaculatory volume; 14 (24.5%) hypovolaemia, 2 (3.5%) hypervolaemic, and 41 (72%) normovolaemia, (d) Based on viscosity: 53 (93 %) Normoviscosity, and 4 (7%) hyperviscocity. In conclusion, Infertility in the studied population was caused by high percentage of spermatozoa with abnormal morphology.
Pharmacognostic and pharmacological evaluation of Syzygium caryophyllatum L. and Syzygium cumini L.
Authors: Fathimath Riza and Laveena K B
Published: October 2023

India is one of the nation blessed with a rich heritage of traditional medical systems and rich biodiversity to complement the herbal needs of the treatment administered by these traditional medical systems. The recognized Indian Systems of Medicine are Ayurveda, Siddha and Unani, which use herbs and minerals in the formulations. The antioxidant compounds are mostly produced in plants in the form of secondary metabolites. Phytochemicals can be literally referred to as ‘plant-chemicals’. They are the non-nutritive chemical components of plants that possess numerous health benefits and disease prevention properties. Leaf chlorophyll concentration is an important parameter that is regularly measured as an indicator of chloroplast content, photosynthetic mechanism and of plant metabolism. Chlorophyll is an antioxidant compounds which are present and stored in the chloroplast of green leaf plants and mainly it is present in the green area of leaves, stems, flowers and roots. The aim of this study was to observe antioxidant activity from the leaves of S. caryophyllatum and S. cumini and also to evaluate the qualitative and quantitative phytochemical analysis. The present study emphasizes the pharmacognostical study of the plant, chief chemical constituents, present in the plant S. caryophyllatum and S. cumini, and their pharmacological properties. The selected plants (S. caryophyllatum and S. cumini) have been used as a source for the development of medicines and neutraceuticals. Both plant samples contained bioactive chemicals that have pharmacological or toxicological effects. Both showed the presence of secondary metabolites such as steroids, glycosides, phenolics, tannins, anthocyanins, flavonoids, and alkaloids. Plant extracts antioxidant activity may be attributed to their phenolic and flavonoid content. Because of their phytoconstituents, antioxidants, and antibacterial properties, plants offer enormous potential for use in the pharmaceutical business and medicine.
Cold Agglutinin Disease in a Rhesus Macaque (Macaca mulatta)
Authors: Kamperschroer Cris , Tartaro Karrie , Goodchild Laurie , Menke Chelsea , Artrip Ashley , Pisharath Harshan
Published: October 2023

Cold agglutinin disease (CAD) is a condition involving anemia and its related symptoms; it is caused by autoantibodiesthat bind and agglutinate red blood cells in areas susceptible to hypothermia, such as extremities exposed to cold temperatures.CAD is rare, with 5 to 20 human cases per million individuals. In this report, we describe a case of CAD in a previouslyhealthy and experimentally naïve adult Indian rhesus macaque that was housed indoors and presented with blood in theurine. After our observations of hemoglobinuria and anemia led us to suspect CAD, we demonstrated that the macaque’sblood agglutinated at reduced temperatures. We also noticed that the provision of cold foraging treats triggered episodes ofhemoglobinuria. Further investigation revealed that serum from the macaque agglutinated RBCs in vitro with high thermalamplitude (at or below 30 °C) and had an antibody titer of 8 to 32. The serum contained autoantibodies of the immunoglobulinM (IgM) isotype; agglutinins of the IgG isotype were not detected. The cold-dependent IgM autoantibodies in the serum fromthe affected macaque reacted against a common RBC antigen because RBCs collected from other macaques were bound andagglutinated by the affected animal’s IgM under cold conditions. This in vitro binding activity was reversible when the testtemperature was returned to normal body temperature (37 °C). These findings demonstrated cold-dependent RBC-specific IgMagglutinins and led us to a diagnosis of CAD. This is the first documented case of spontaneous CAD in a rhesus macaque.
Rancang Bangun Aplikasi Data Mining untuk Klasifikasi Pemakaian Obat dengan Metode Naïve Bayes pada Puskesmas Bandar baru
Authors: Fachrina Itsna , Indrawati Indrawati , Atthariq Atthariq
Published: October 2023

Salah satu elemen penting dalam meningkatkan kualitas layanan kesehatan adalah ketersediaan obat-obatan yang memadai. Perlu adanya cara untuk mengelola obat dengan benar, efisien dan efektif secara berkelanjutan dengan koordinasi yang baik. Terbatasnya pengetahuan manajemen sehingga kegiatan pelayanan pada puskesmas dalam menyediakan obat masih menggunakan cara yang bersifat konvensional yang hanya berorientasi pada produk yang terbatas dan belum menggunakan sistem komputerisasi sehingga sulit bagi puskesmas untuk mengetahui data obat yang tersedia. Penelitian ini bertujuan untuk mengetahui tingkat akurasi keberhasilan metode naïve bayes dalam mengklasifikan pemakaian obat-obatan, obat mana saja yang memiliki tingkat pemakaian yang banyak diperlukan pada unit pelayanan kesehatan. Penerapan metode naïve bayes data mining akan menghasilkan tiga kategori obat, yaitu kategori obat dengan pemakaian yang banyak, sedang, dan sedikit yang dapat digunakan sebagai referensi perencanaan inventaris pada tahun berikutnya. Penelitian ini berhasil menerapkan metode naïve bayes ke dalam aplikasi. Hasil presentase akurasi pengujian pertama adalah 78,58%, pengujian kedua adalah 76,67%, pengujian ketiga adalah 84%AbstractOne of the important elements in improving the quality of health services is the availability of adequate medicines. There needs to be a way to administer drugs properly, efficiently and effectively in a sustainable manner with good coordination. Limited knowledge of management so that service activities at the health center in providing medicine still use conventional methods which are only oriented towards limited products and have not used a computerized system so that it is difficult for puskesmas to find out the available drug data. This study aims to determine the level of accuracy of the success of the naïve Bayes method in classifying the use of drugs, which drugs have a high level of use in health care units. The application of the naïve Bayes data mining method will produce three categories of drugs, namely the category of drugs with high, moderate, and small use that can be used as a reference for inventory planning in the following year. This research succeeded in applying the naïve Bayes method to the application. The result of the percentage accuracy of the first test is 78.58%, the second test is 76.67%, the third test is 84%
Penerapan Rekomendasi Menu dan Self Order Pada Aplikasi E-Menu Restoran Menggunakan Metode Collaborative Filtering Berbasis Android
Authors: Aziz Ryandi
Published: October 2023

Perkembangan zaman telah membuat banyak pelaku bisnis khususnya kuliner semakin berinovasi dalam produk atau menu makanan dan minuman untuk meningkatkan penjualan. Pelayanan yang diberikan kepada pelanggan pada sebuah restoran juga berpengaruh dalam hal peningkatan penjualan. Ada tiga kondisi yang dapat menurunkan kualitas pelayanan sebuah restoran yaitu saat pelanggan ramai, beroperasi lebih dari 2 lantai dan tempat yang luas. Penurunan kualitas pelayanan bagi pelanggan berdampak terhadapat penjualan. Kondisi tersebut dapat diminimalisir dengan penerapan teknologi aplikasi mobile (e-menu). Penggunaan aplikasi android untuk dapat membantu dalam meningkatkan kualitas pelayanan khususnya dalam hal pemesanan makanan dan minuman. Aplikasi pemesanan yang dibangun memungkinkan pelanggan untuk dapat memesan dan membayar secara mandiri. Proses pemesanan dilakukan dengan cara, pelanggan dapat memindai QR code yang tersedia pada meja. Proses pembayaran dapat dilakukan setelah proses pemesanan menggunakan payment gateaway. Aplikasi yang dikembangkan ini dilengkapi dengan fitur rekomendasi menu dengan dukungan metode collaborative filtering. Penerapan aplikasi pemesanan makanan dengan android dapat meningkatkan kualitas pelayanan yaitu pemesanan dan pembayaran menjadi lebih cepat.
Monitoring dan Kontrol Pembibitan Tanaman Cabai Berbasis IoT (Internet of Things)
Authors: Trisnawati Trisnawati , Atthariq Atthariq , Safriadi Safriadi
Published: October 2023

IoT (Internet of Thing) merupakan suatu teknologi yang diciptakan untuk membantu mempermudah pekerjaan manusia. Pada saat ini hampir semua alat atau perangkat yang digunkan terhubung dengan internet. Sistem dengan IoT sudah digunakan dalam berbagai bidang salah satunya yaitu bidang pertanian. Pada bidang pertanian kesuburan lahan tanamam menjadi salah satu aspek yang peting, karena pengaruh dari lahan pertanian akan berakibat pada tanaman dan hasil panen yang akan di dapatkan. Metode yang digunakan yaitu rancang bangun suatu sistem yang dimulai dengan merancang perangkat keras dan kemudian menghubungkan perangkat ke software Blynk dengan menggunkan internet.Pada penelitian ini bertujuan untuk merancang dan membuat alat monitoring kelembaban, pH tanah dan suhu tanah untuk mendukung proses pertumbuhan tanah pada proses pembibitan tanaman cabai berbasis aplikasi Blynk. Pada proses pertumbuhan tanaman cabai membutuhkan kelembapan tanah dan suhu yang sesuai agar proses tumbuhnya dapat maksimal. Dengan adanya teknologi Internet of Things (IoT) dapat mudahkan seorang petani untuk melakukan kontroling terhadap kebutuhan air yang sesuai untuk tanaman cabai. Ditambahkan juga dengan penempatan sistem IoT yang digunkan untuk membatu proses irigasi atau perairan pada tanaman cabai dengan melakukan kontroling untuk menyakan dan mematikan menggunkan aplikasi Blynk. Perangkat IoT yang digunakan untuk membebuat sistem ini meliputi NodeMCU, sensor suhu, sensor pH, sensor kelembaban tanah, relay, pompa air dan aplikasi blynk sebagai perangkat lunak pengontrol perangkat IoT. Untuk hasil penelitian ini disimpulkan adalah pada saat pengujian berhasil dijalankan dan dapat bekerja dengan baik dan semua alat yang digunkan bekerja dengan persentase keakuratan sistem 80%.
CERT-UA assessment based on the CSIRT ENISA Maturity Model
Authors: Peliukh O.I. , Yesina M.V. , Holubnychyi D.Yu.
Published: October 2023

Cybersecurity threats are steadily increasing in today's world, which is characterised by increased openness and integration into the global network. The proliferation of cyber incidents, including hacker attacks, confidential data leaks and information theft, is becoming an extremely pressing issue in this context. Accordingly, the eradication of these threats requires the development of effective methods of responding to cyber incidents. The central theme of this article is to consider the critical importance of assessing and improving the effectiveness of cyber incident response teams. The structure of such a team, including cybersecurity specialists, network engineers, analysts, etc., is aimed at identifying, analysing and overcoming threats in cyberspace. The key aspects of assessing such a team, like abilities, experience, communication skills and level of cooperation, are presented clearly through the prism of the updated ENISA CSIRT Maturity Model. The article uses the Computer Emergency Response Team in Ukraine (CERT-UA), a national team operating under the leadership of the State Service for Special Communications and Information Protection of Ukraine, to illustrate the methods of assessing a cyber incident response team. The assessment of the team, based on the ENISA CSIRT Maturity Model, points to key aspects that determine its effectiveness. The paper provides a clear view of the process of measuring cyber incident response teams through a systematic approach that identifies their strengths and weaknesses. The maturity analysis of the CERT-UA provides recommendations for further development of the team, which can be an important resource for academics, cybersecurity experts and government officials interested in improving the effectiveness of cyber threat response. It highlights the importance of assessing cyber incident response teams to ensure cybersecurity and information protection. Awareness of this issue contributes to continuous improvement and readiness to respond effectively to growing challenges in the modern digital environment.
Genetic control of yield components in green beans (Phaseolus vulgaris L.)
Authors: Contreras-Rojas M. , Guzmán D. G.G. , Salazar Mercado S. A.
Published: October 2023

Background. This work aimed at using Hayman’s methodology to study the inheritance of some quantitative traits, such as the number of pods per plant, pod length, mean pod weight, and yield per plant in 15 diallel hybrids of six green bean cultivars.

Materials and methods. The research was carried out at the Experimental Center of Universidad Nacional de Colombia – Sede Palmira (CEUNP). A randomized complete block experimental design with four replications was used.

Results. For most of the traits, except yield per plant, the additive-dominant model was adequate. Non-additive effects with overdominance controlled the number of pods per plant, pod length, and mean pod weight. Most of the characters presented an unequal proportion of positive and negative genes in the loci (H1 < H2). The asymmetric distribution of genes in the parents (H2/4H1) was below the maximum value (0.25), except for the character “number of pods per plant”. The KD/KR ratio confirmed for most of the traits that there was an excess of recessive alleles over dominant alleles. Dominance effects (h2) for most char-

acters suggested that the substantial contribution of dominance was not due to heterogeneity of loci in these characters. The narrow-sense heritability was moderate to low. The correlation coefficient r (Yr; Wr + Vr) indicated that dominant genes were responsible for the increased number of pods per plant and recessive genes for increased pod length and mean pod weight.

Conclusions. Conventional breeding methods like pedigree selection could be employed to improve the characters “pod length” and “mean pod weight”, and for the number of pods per plant, management of segregating populations should employ the single-seeded descent method.
Comparative ecological testing of Achillea millefolium (L.) cultivars in Moscow Province
Authors: Korotkikh I. N. , Nevkrytaya N. V. , Platonova T. V.
Published: October 2023

Background. The cultivars of Achillea millefolium L.: ‘Eney’ and ‘Millennium’ (Research Institute of Agriculture of Crimea), and ‘Vasyurinsky’ (North-Caucasian Branch of VILAR), were the objects of the ecological testing in 2018–2020 in Moscow Province.

Methods. A nursery was established with planting material of vegetative origin. Phenological and morphometric parameters, indicators of raw matter productivity, and crop structure components were assessed in the phase of mass flowering.

Results. For cv. ‘Vasyurinsky’, the start of growing and subsequent phenological phases occurred 14–25 days earlier than for ‘Eney’ and ‘Millennium’ whose growing season was 15–20 days longer. The plant height varied from 72 to 106 cm for cv. ‘Vasyurinsky’, 43 to 56 cm for ‘Eney’, and 38 to 42 cm for ‘Millenium’. The yield of fresh green biomass reached 8.8–10.3 t/ha for the Crimean cultivars, and 18.2 t/ha for ‘Vasyurinsky’. The latter exceeded cvs. ‘Eney’ and ‘Millenium’ in the yield of green biomass and air-dry matter (1.7–2.9 and 1.5–2.6 times, respectively). Essential oil content in ‘Eney’ was 4.74% of the absolute dry weight, being 1.6–3.5 times higher than in ‘Millenium’ (2.99%) and ‘Vasyurinsky’ (1.35%). Chamazulene content in the essential oil of the Crimean cultivars was 10–12 times higher, and the content of caryophyllene and germacrene D 2.5–3.1 times higher than in the essential oil of cv. ‘Vasyurinsky’.

Conclusion. All the studied cultivars of A. millefolium can be recommended for commercial cultivation in Moscow Province.
Genetic structure of the collection of ryegrass (Lolium) cultivars: a study based on SSR and SCoT markers
Authors: Mavlyutov Yu. M. , Vertikova E. A. , Shamustakimova A. O. , Klimenko I. A.
Published: October 2023

Background. Current molecular and genetic approaches make it possible to accelerate ryegrass breeding, simplify source material evaluation, and increase its accuracy. The efficiency of PCR-based SSR and SCoT marker techniques was studied in the context of evaluating the genetic structure of annual and perennial ryegrass accessions and defining DNA-identifying markers.

Materials and methods. Genomic DNA was isolated from the aggregate sample of 30 seedlings from each of the 15 analyzed cultivars according to the modified SDS DNA extraction protocol. In total, 20 SSR and 22 SCoT markers were used to assess genetic polymorphism. Basic parameters of the markers’ informative efficiency were identified. Genetic relationships among the studied cultivars were analyzed on the basis of the Neighbor-Joining dendrogram and Bayesian model.

Results. To assess the genetic polymorphism of ryegrass species and varieties, 7 SSR loci were selected, for which 110 allelic variants were identified (34 alleles were unique for individual cultivars), and 9 SCoT loci, for which 78 polymorphic amplification fragments were identified, with 28 being cultivar-specific. The dendrogram of genetic similarity and modeling in the Structure v2.3.4 program according to the results of SSR and SCoT analyses distributed the cultivars by their traits according to their species, ploidy level, origin, and similarity. Based on PCoA, carried out using summarized data of SSR and SCoT analyses, a multidimensional diagram of genetic relationships among ryegrass cultivars was constructed.

Conclusions. The systems of SSR and SCoT markers appeared to be an efficient tool to reveal genetic polymorphism and identify differences among ryegrass species and cultivars. We found unique DNA profiles that can be used for genetic identification. The results of the study have practical significance in cultivar-specific identification and selection of cultivars for various purposes.
In situ and ex situ variability of phenological and morphological features in Caltha palustris L. under the conditions of the West Siberian forest steppe
Authors: Fomina Т. I.
Published: October 2023

Background. Caltha palustris L. is known as a medicinal, food, and ornamental plant. It is a circumboreal species, and hygrohelophyte. Due to its ecological specificity, this plant can be used to study the response to an abrupt change in environments. The goal was to assess the variance in phenological and morphological features of C. palustris in the forest steppe of Western Siberia.

Materials and methods. Phenotypic characters of the native population and the accessions introduced from Kemerovo Province and Altai Territory were studied. Phenological observations followed a well-known technique for herbaceous perennials. Morphometric data were processed in the PAST program using statistical indicators: the arithmetic mean with an error (M ± mM), minimum and maximum values of the trait (lim), and coefficient of variation (Cv). Significance of differences was assessed using Student’s t-test (Pt) at a 5% significance level. For traits deviating from the normal distribution, the significance of differences was assessed using the Mann–Whitney criterion (PMW) by median values of the trait (Me) at the same 5% level.

Results and conclusions. The accessions varied significantly in the timing and duration of phenophases. Plants in the native population grew later and bloomed for a long time because of the variation in microconditions. Ex situ plants produced the second generation of rosette shoots and were capable of long vegetating, but the Altai accession differed in later growth and shorter phenophases. All accessions significantly differed in morphological characteristics of the shoot, except for flower size. The introduced accessions were inferior to the native ones in shoot height, leaf size, and number of flowers due to non-optimal cultivation environments. Since C. palustris demonstrated high individual and interpopulation variability, it is promising to study this species in different natural populations and select the most ornamental and sustainable accessions.
Vsevolod L. Vitkovsky (1928–2005): dedication to his 95th birthday
Authors: Ukhatova Yu. V. , Shlyavas A. V.
Published: October 2023

In 2023, the 95th anniversary has been commemorated since the birth of Professor Vsevolod L. Vitkovsky, Doctor of Biological Sciences, a prominent scientist and fruit expert, one of the eldest staff members of the Department of Fruit Crop Genetic Resources at the Vavilov Institute.