bluuebunny/crossref_metadata_2025 huggingface dataset:
H. White – a Historian and Literary Critic
Authors: Егоров Д.И.
Published: April 2023

В статье описаны ключевые теоретические проблемы, объединяющие работы разных этапов творческого пути американского историка и литературоведа Х. Уайта. Статья носит коммеморативный характер, поэтому в ней не изложены во многом справедливые аргументы критики его исследований. Отклонившись от сложившейся традиции анализа взглядов Х. Уайта в качестве проявления постмодернизма и деконструктивизма в историографии, они представлены в том виде, в котором он стремился позиционировать их сам. А именно в виде модернистского понимания роли эстетического аспекта в историческом повествовании и структуралистского анализа его форм. Также, в связи с различными интерпретациями идейных источников теоретического содержания исследований Х. Уайта, была рассмотрена роль тех источников, которым он сам отводил ведущее значение. Это работы Ж.П. Сартра, Б. Кроче, Р. Якобсона, Р. Барта и М. Фуко.

The article describes the key theoretical problems that unite the works of different periods of the creative path of the American historian and literary critic H. White. The article is of a commemorative nature, therefore, it does not present largely fair arguments for criticizing his research. Deviating from the established tradition of analyzing the views of H. White as a manifestation of postmodernism and deconstructivism in historiography, they are presented in the form in which he sought to position them himself. Namely, in the form of a modernist understanding of the role of the aesthetic aspect in historical narratives and a structuralist analysis of their forms. But, in connection with the various definitions of the ideological sources of the theoretical and methodological aspects of his research, the role of those sources to which he himself assigned leading importance was considered. These are the views of J.-P. Sartre, B. Croce, R. Jacobson, R. Barth and M. Foucault.
Manifestações Bucais e Alterações Dentárias em Pacientes com Anemia Falciforme: uma Atualização
Authors: Grossi Letícia Dantas , Biancardi Mariel Ruivo , Sarmento Viviane Almeida , Rubira Cassia Maria Fischer , Rubira-Bullen Izabel Regina Fischer
Published: April 2023

A doença falciforme é uma hemoglobinopatia autossômica hereditária, na qual ocorre uma mutação na cadeia beta da hemoglobina. Essa mutação leva a uma alteração da hemoglobina normal HbA, em hemoglobina C (HbC) ou hemoglobina D (HbD), o que implica em um quadro de desoxigenação tecidual e falcização das hemácias, que determina sua destruição prematura e anemia hemolítica. As características clínicas da doença variam em episódios de dor, decorrente do mecanismo de vaso oclusão, danos a órgãos e infecções, principalmente oportunistas, devido ao quadro grave de imunossupressão desses pacientes. As complicações odontológicas são de grande relevância, levando em consideração que esses pacientes podem apresentar diversas manifestações bucais e uma infecção dentária complicada por uma crise falciforme, aumenta significativamente, a probabilidade de admissão hospitalar.
Análise da Estabilidade de Cor e Brilho de Materiais Restauradores de Incremento Único Expostos a Bebida Corante e Ácida
Authors: Zago Taísa Freitas , Briso André Luiz Fraga , Ali Yasmine Parischi Musa , Omoto Érika Mayumi , Gonçalves Diego Felipe Mardegan , Mauro Silvio José , Fagundes Ticiane Cestari
Published: April 2023

A inserção de incrementos únicos é uma característica vantajosa no que se refere à redução do tempo de procedimento clínico. Dessa forma, o objetivo deste estudo foi avaliar a estabilidade de cor e brilho de materiais restauradores de incremento único expostos à bebida corante e ácida. Foram avaliados dois tipos de resina composta, uma de inserção incremental (FT) e outra de incremento único (BK); assim como, dois cimentos ionoméricos de alta viscosidade, um sem cobertura de proteção (KT) e outro com cobertura de proteção com carga nanoparticulada (EQ). Para cada material restaurador foram confeccionados 26 discos (5 mm de diâmetro e 4 mm de espessura), totalizando 104 corpos de prova. Os espécimes foram aleatoriamente divididos em subgrupos para as seguintes imersões: saliva artificial e Coca-Cola. Foi avaliada a alteração de cor e brilho entre os diferentes tipos de materiais, antes e após as imersões propostas. Os dados obtidos para alteração de cor e brilho foram submetidos ao teste de análise de variância dois critérios e o brilho foi avaliado pela análise de variância dois critérios medidas repetidas. Para todas as análises foi realizado o pós-teste de Tukey, com nível de significância de 5%. Com relação aos resultados de cor, a resina FT apresentou maior alteração do que BK em Coca-cola, sendo que para saliva o oposto ocorreu. Já para os cimentos ionoméricos, o KT obteve a maior alteração em Coca-Cola. Não houve diferença estatística entre as resinas para alteração de brilho, no entanto, KT apresentou maior alteração quando imerso em Coca-Cola do que saliva. Desse modo conclui-se que a resina composta de inserção única sofreu menos a ação da bebida corante e ácida na alteração de cor. Para os CIVs, KT apresentou maior alteração cromática e de brilho, quando comparado ao EQ. Assim, a cobertura nanoparticulada forneceu proteção adicional ao material restaurador híbrido.
Target therapy of polycystic ovary syndrome
Authors: Turchinets A. I. , Uvarova E. V. , Khashchenko E. P. , Kumykova Z. Kh.
Published: April 2023

Due to the complexity of the diagnosis and treatment of polycystic ovary syndrome (PCOS) in adolescents, studies are currently underway to select targeted therapy to normalize the metabolic and reproductive status of girls, including those at risk for PCOS. There are a  lot of  researches, that evaluate the  effectiveness of  inositol therapy in  PCOS, ovarian dysfunction, insulin resistance (IR), ovarian hyperandrogenism in both adolescents and adult women, including those in IVF cycles. Currently, the choice of determining the ratio of myo-inositol (MI) and d-chiro-inositol (DCI) for the treatment of PCOS often leads to the physiological proportion of inositols in plasma (40:1), since research results are insufficient to unambiguously confirm it. In this connection, there is a large number of pharmaceuticals without or with a low dosage of DCI, that can’t bypass the defective epimerase activity and achieve an adequate level of DCI in the ovaries. Determination of a fair assessment and dosage of MI/DCI is required for long-term correction of metabolic, endocrinological and clinical manifestations of various PCOS phenotypes. Inositols are promising and safe treatment of hyperandrogenism, obesity, insulin resistance in women of various age groups and can also effectively complement a therapeutic effect of metformin and combined oral contraceptives.
Discussion issues in the treatment of chronic endometritis
Authors: Dikke G. B.
Published: April 2023

The prevalence of  chronic endometritis  (CE) in  the general population ranges from 14.1  to 24.4% and is 2–3  times higher in patients with impaired reproductive function. The treatment of CE presents certain difficulties due to different approaches and conflicting information about the effectiveness of the methods used. According to studies, the cure rate of CE with antibiotics (AB) is 82.6–87.9% with a live birth rate of 56–62.4%. In ART programs in patients who have undergone a course of AB-therapy, there is a 5-fold increase in the frequency of live births. The need to reach a consensus on the diagnostic criteria for CE was noted to exclude the influence of study heterogeneity on treatment outcomes. In recent years, the need to restore immune protection in CE has been widely discussed. Of the immunomodulators available in the Russian Federation with proven efficacy is a complex of exogenous natural cytokines and chemokines, the use of which in combination with AB allows to achieve elimination of pathogens in 86% of patients with CE of viral and bacterial aetiology (56% in the treatment of AB alone) and achieve pregnancy, ended in childbirth, in 60% of cases (29% without cytokines). Immune function can be improved by addressing micronutrient deficiencies, in particular the vitamin and mineral complex Pregnoton, which can contribute to increased resistance to infection, faster recovery, and improved reproductive function. Treatment of CE should include broad-spectrum antibiotic therapy and antiviral therapy aimed at reducing the activity of viruses. The complex of exogenous natural cytokines and chemokines for topical application helps to increase the rates of pregnancy and live births. Biologically active supplements, including the Pregnoton vitaminmineral complex, can be used as additional means to improve the functions of innate and acquired immunity.
Dispensary group of women with benign diseases of the mammary glands: a school of prevention, observation, examination, treatment
Authors: Sukhareva E. A. , Somov A. N.
Published: April 2023

Introduction. The issues of dispensary check-ups for women with benign breast diseases (BBD) still remain an urgent challenge. What stands out are delayed visits to the doctor, irregular examinations and failure to follow prescribed therapy. Women’s health schools equipped with state-of-the -art information and communication technologies contribute to improving motivation for regular check-ups, timely examinations and adherence to treatment.

Aim. To study the impact of training on adherence to regular visits, examination and treatment provided to a dispensary group of women with BBD at the Prevention School.

Materials and methods. A total of 486 women with BBD who attended the Women’s Health Prevention School were observed. A professional medical advice included a gynaecological screening and consultation with an oncologist, breast ultrasound imaging for women of all age groups and mammography for women aged 40 years and older; once diffuse benign changes to breast tissues were detected, the women were prescribed Mastodynon (Bionorica SE) for 3 months.

Results. After training, the rates of visits to a doctor increased from 69.3% to 94.2%, the examination rates increased from 66.8% to 88.6%, adherence to regular therapy increased from 43.6% to 82.9%. 82.9% of women reported health improvements after therapy with the herbal medicine, 7.6% – absence of changes, 4.3% – deterioration in the condition, of which 2.6% – menstrual disorders, 5.2% women discontinued therapy (due to poor tolerance – 3.6%, skin reactions – 1.0%, family reasons – 0.6%).

Conclusion. Raising women’s awareness about breast cancer and a set of measures increase the early detection of breast diseases and women’s cancer alertness.
Effective preconception preparation for women with iron deficiency
Authors: Mikhailova O. I. , Tyutyunnik V. L. , Kan N. E. , Mirzabekova D. D.
Published: April 2023

Introduction. Latent iron deficiency, which has a high prevalence among women of childbearing age, most often, in the absence of therapy, progresses in pregnant women into manifest iron deficiency, manifested by clinical symptoms of anemia and associated with a complicated course of pregnancy, childbirth, the postpartum period, unfavorable outcomes of newborns. The above justifies the need for correction of iron deficiency at the preconception period.

Aim. To evaluate the effectiveness of therapy latent iron deficiency at the stage of preconception period.

Materials and methods. The study included 32 women at the stage of pregnancy planning with latent iron deficiency. All women taking the drug Ferretab 1 pill per day for 1 month. The level of blood parameters was assessed at 3 months before the intended conception, in the I, II and III trimesters of pregnancy, in the 3rd day after delivery. In newborns, the indicators of a clinical blood test were evaluated on the 2nd day after birth. We evaluated such indicators as the level of hemoglobin, erythrocytes, hematocrit, the average content of hemoglobin in erythrocytes, serum ferritin, serum iron, transferrin.

Results. Evaluation of laboratory data in the course of the study confirmed the effectiveness of the use the complex drug Ferretab. Patients already at the first visit to the doctor during pregnancy had a positive trend and a significant increase in the level of hematological parameters.

Conclusions. Oral administration of the complex drug Ferretab showed high efficiency in the treatment of latent iron deficiency at the stage of preconception period, significantly increasing the levels of hematological parameters, good tolerance and a small number of side effects, contribute to the high adherence of patients to therapy, which allows achieving significant clinical results.
Polymorphism of vascular homeostasis genes as a risk factor for the formation of preeclampsia
Authors: Elykova A. V. , Orlova V. S , Batlutskaya I. V. , Sorokina I. N. , Efremova O. A. , Rudyh N. A. , Churnosov M. I.
Published: April 2023

Introduction. Preeclampsia (PE) is a serious complication of pregnancy that occurs in 3-8% of pregnant women and is the leading cause of maternal and perinatal morbidity and mortality.

Aim. To evaluate the role of vascular homeostasis gene polymorphism in the formation of preeclampsia.

Materials and methods. The sample for this study included 250 women with preeclampsia and 209 women with normal gestation (control group). Five polymorphic loci of vascular homeostasis genes were selected for analysis: α-adducin (G460W ADD1), β2-adrenoceptor (+46G/A ADRB2), endothelin-1 (Lys198Asn EDN1) encoding the β3 G protein subunit (G/A GNB3), cytochrome 3A5 (+6986G/A CYP3A5). The molecular genetic study of all SNPs was carried out by polymerase chain reaction.

Results. It was found that genetic variants determine the  risk of  developing preeclampsia. The allelic variant 198Lys EDN1  (84.80%) occurs in  women with a  clinical diagnosis of  PE significantly more often than in  women of  the control group (79.67%) (p = 0.05; OR = 1.43; 95%CI 1.01–2.03). At the same time, among pregnant women without PE, combinations of 198Asn EDN1 x +46 A ADRB2 (23.65%) and 198Asn EDN1 x 460 ADD1 x +46 A ADRB2 (23.65%) are registered 1.6–1.7 times more often than among women with PE (14.46 and 13.65%, respectively, рperm = 0.032). Conclusion. The risk factor for the formation of preeclampsia is the 198Lys EDN1 allele (OR = 1.43), and combinations of genetic variants 198Asn EDN1 х +46 A ADRB2 (OR = 0.55) and 198Asn EDN1 х +46 A ADRB2 х 460G ADD1 (OR = 0.51) have a protective value.
Time series data and rainfall pattern subjected to climate change using non-parametric tests over a vulnerable region of Karnataka, India
Authors: Kumar Sanjay , Ahmed S. A. , Karkala Jyothika
Published: April 2023

Fluctuations in the precipitation pattern often tend to have an impact on the availability of water, making it necessary to explore spatiotemporal variations in rainfall. This study explores the time series analysis of the rainfall from 1952 to 2019. The trend was analyzed using the modified Mann–Kendall test (MMK), and innovative trend analysis (ITA). The analysis showed that the northern region received the least rainfall while the southern region received the maximum rainfall except that one of the stations had a positive kurtosis. The kurtosis of the rainfall histogram ranges from −0.69 to 24.13. The trend was very well defined by all the methods, though MMK z statistics showed more occurrences of significant changes in the rainfall. The northeast monsoon carried a significantly decreasing trend at Chikkanayakanahalli station where the z value of MMK and ITA_R test showed values of −1.33 and −2.23, respectively, while all of the significantly increasing trends were defined by the MMK test in the annual and southwest monsoon season. The homogeneity test showed the most correlation between Pettitt and Buishand tests in comparison to SNHT. Later, the ARIMA model was run for the precipitation to predict the rainfall value from 2019 to 2029.
Wastewater reuse and recycling of the steel industry in China: history, current situation, and future perspectives
Authors: Liang Siyi , Du Ye , Liu Qi , Li Jiankang , Liu Zhi , Xu Yan , Chen Zhuo , Wu Yin-Hu , Hu Hong-Ying
Published: April 2023

China is the largest steel producer in the world. Effective methods to alleviate the contradiction between water supply and water demand of the iron and steel industry in China are to implement the recycling of wastewater from the iron and steel industry and develop unconventional water resources. This paper reviews the development of wastewater recycling in the iron and steel industry in China in the past 40 years (1980–2020). During this period, steel output has increased from 36 to 1,053 million tons, freshwater consumption per ton of steel has decreased from 35.9 to 2.45 tons, and water resources reuse has soared from 61.2 to 98.02%. Four typical cases, including the Anyang Steel Group, the Tangshan Steel Group, the Tianjin Steel Group, and the Taihang Steel Group, were analyzed. In addition, a water efficiency research project of iron and steel enterprises in China was carried out in 2019. Statistical analyses on wastewater recycling rate, reuse rate, direct cooling water circulation rate, and other indicators were performed. The recycling of wastewater in the iron and steel industry would be continuously improved by policy drivers, economic drivers, and technical drivers.
Gaining distance learning effectiveness through mental health improvement during the COVID-19 pandemic: The role of patience
Authors: Nazilah A. , Ibrahim Raja Zirwatul Aida Raja , Saputra Jumadil , Dagang Mazidah , Ibrahim Che Wan Ida Rahimah Che Wan , Bakar Norsuhaily Abu
Published: April 2023

Nowadays, the COVID-19 pandemic has impacted communities' mental health worldwide. Therefore, studies on minimizing the pandemic's mental health impact are urgently needed. This study aimed to examine the role of patience on distance learners' mental health during the COVID-19 pandemic. A correlational study was conducted involving a total of 330 university students of distance learners, and they were selected using stratified random sampling. The Patience Scale (PS-11) was used to measure interpersonal patience, life hardships patience, and daily hassles patience. The Depression, Anxiety, and Stress Scale (DASS-21) were used to measure mental health from the aspects of depression, anxiety, and stress. The data were analyzed using descriptive analysis and multiple regression. The study showed that life hardships and patience were predictors of reducing depression and anxiety. Besides that, life hardships patience and interpersonal patience were predictors of reducing stress, and the main contributing factor was life hardships patience. This study contributes to humanistic therapy theories and their practical implications. It also contributes to developing the national mental health policy strategy, Ministry of Health Malaysia, and Sustainable Development Goals 2030.
Enseñanza-aprendizaje en línea en la Universidad de Guayaquil durante el confinamiento por la pandemia de Covid-19
Authors: Sáenz De Viteri Anzules Cristian Roosevelt , Alvarado Pignataro Daniella Francesa , Villao Maridueña Roberto Carlos
Published: April 2023

Todo el sistema educativo, desde el nivel primario hasta el terciario, se ha colapsado durante el período de bloqueo de la nueva enfermedad del coronavirus 2019 (COVID-19), no solo en Ecuador sino en todo el mundo. Este estudio es un retrato de los modos de enseñanza-aprendizaje en línea adoptados por la Universidad de Guayaquil para el proceso de enseñanza-aprendizaje y los exámenes semestrales posteriores. Espera una oportunidad intelectualmente enriquecida para una mayor toma de decisiones académicas en el futuro durante cualquier adversidad. El propósito previsto de este documento busca abordar los aspectos esenciales requeridos de la enseñanza-aprendizaje en línea en la educación en medio de la pandemia de COVID-19 y cómo pueden los recursos existentes de las instituciones educativas transformar de manera efectiva la educación formal en educación en línea con la ayuda de clases virtuales y otras actividades en línea, fundamentales en este panorama educativo en constante cambio. El documento emplea un enfoque tanto cuantitativo como cualitativo para estudiar las percepciones de profesores y estudiantes sobre los modos de enseñanza-aprendizaje en línea y también destaca el proceso de implementación de los modos de enseñanza-aprendizaje en línea. El valor de este documento es dibujar una imagen holística de las actividades de enseñanza-aprendizaje en línea en curso durante el período de cierre, incluido el establecimiento del vínculo entre el proceso de gestión del cambio y el proceso de enseñanza-aprendizaje en línea en el sistema educativo en medio del brote de COVID-19 a fin de superar la perturbación académica persistente y, en consecuencia, asegurar la reanudación de las actividades y discursos educativos como un curso normal de procedimiento en el sistema educativo.
Modelo de volatilidad de las acciones de Tesla Motors Inc. Fluctuaciones de los precios del cobalto y el litio
Authors: Vergara Arnaldo , Romero Subia José Fernando , Ochoa Rico María-Salomé , Romero Lainez Juanita
Published: April 2023

El avance y la innovación tecnológica actual han aumentado la importancia de metales críticos como el cobalto y, en menor medida, el litio. Estos metales son necesarios para la fabricación de baterías, en concreto las que se utilizan en los vehículos eléctricos. El espectacular aumento de la demanda de estos metales se ha traducido en un aumento significativo del precio debido a la limitada disponibilidad. Tesla Motors Inc., que ha desarrollado las baterías más eficientes y duraderas para la producción de sus vehículos eléctricos, es una de las empresas más vulnerables a los cambios en los precios del cobalto y el litio. El propósito de este documento es analizar cómo las fluctuaciones de los precios del cobalto y el litio afectan la volatilidad de las acciones de Tesla Motors Inc. Se usará el modelo DCC GARCH para simular las relaciones mutuas entre los choques de precios del cobalto y el litio y la volatilidad de Tesla Motors Inc. Se proporciona un análisis empírico de los datos diarios de los años 2013 a 2018. En general, los hallazgos sugieren que los cambios en los precios del litio pueden tener un impacto significativo en la volatilidad de las acciones de Tesla Motors Inc. a lo largo del tiempo.
Koya Christians and their situation during the 1963 Haras Qawmi attack
Authors: Tayeb Jamal Fathulla
Published: April 2023

The Christian of Koya and Harmota are considered as one of the most important and main components of Koya city, through out history there was a strong relationship between Muslims and Christians of Koya and Harmota and there was the least problems and conflicts emerged between them. They saw each other from the eye of respect and brotherhood in a way that the religious intolerance has no effect on their relationship. They were always inseparable part of Koya's people. As a consequence, in almost all of the political events like wise the Muslims they shared in achievements and losses. Proceeding the Coup events of February 8th 1963, the Bahsists came to power, a militia force labeled as Haras Qawmi has been made out of som Arab tribes. On June 1,1963 Haras Qawmi attacked Koya and surroundings and left a lot of material and human life losses to the city. Christians of Koya were not deprived from those attacks and lootings. The village of Harmota and Christians have undergone those attacks and its people were displeased and some of them have been killed. Despite of these, all their animals and precious instruments were stolen and conqured.
This research composes of an introduction and two parts. The first part is about a brief history of Christians of Koya and Harmota. The second part deals with the Christians of Koya and Harmota during the attacks of the Haras Qawmi in 1963.
An Assessment of How Clinicians and Staff Members Use a Diabetes Artificial Intelligence Prediction Tool: Mixed Methods Study
Authors: Liaw Winston R , Ramos Silva Yessenia , Soltero Erica G , Krist Alex , Stotts Angela L
Published: April 2023

Background

Nearly one-third of patients with diabetes are poorly controlled (hemoglobin A1c≥9%). Identifying at-risk individuals and providing them with effective treatment is an important strategy for preventing poor control.

Objective

This study aims to assess how clinicians and staff members would use a clinical decision support tool based on artificial intelligence (AI) and identify factors that affect adoption.

Methods

This was a mixed methods study that combined semistructured interviews and surveys to assess the perceived usefulness and ease of use, intent to use, and factors affecting tool adoption. We recruited clinicians and staff members from practices that manage diabetes. During the interviews, participants reviewed a sample electronic health record alert and were informed that the tool uses AI to identify those at high risk for poor control. Participants discussed how they would use the tool, whether it would contribute to care, and the factors affecting its implementation. In a survey, participants reported their demographics; rank-ordered factors influencing the adoption of the tool; and reported their perception of the tool’s usefulness as well as their intent to use, ease of use, and organizational support for use. Qualitative data were analyzed using a thematic content analysis approach. We used descriptive statistics to report demographics and analyze the findings of the survey.

Results

In total, 22 individuals participated in the study. Two-thirds (14/22, 63%) of respondents were physicians. Overall, 36% (8/22) of respondents worked in academic health centers, whereas 27% (6/22) of respondents worked in federally qualified health centers. The interviews identified several themes: this tool has the potential to be useful because it provides information that is not currently available and can make care more efficient and effective; clinicians and staff members were concerned about how the tool affects patient-oriented outcomes and clinical workflows; adoption of the tool is dependent on its validation, transparency, actionability, and design and could be increased with changes to the interface and usability; and implementation would require buy-in and need to be tailored to the demands and resources of clinics and communities. Survey findings supported these themes, as 77% (17/22) of participants somewhat, moderately, or strongly agreed that they would use the tool, whereas these figures were 82% (18/22) for usefulness, 82% (18/22) for ease of use, and 68% (15/22) for clinic support. The 2 highest ranked factors affecting adoption were whether the tool improves health and the accuracy of the tool.

Conclusions

Most participants found the tool to be easy to use and useful, although they had concerns about alert fatigue, bias, and transparency. These data will be used to enhance the design of an AI tool.
Effectiveness of Social Virtual Reality Training in Enhancing Social Interaction Skills in Children With Attention-Deficit/Hyperactivity Disorder: Protocol for a Three-Arm Pilot Randomized Controlled Trial (Preprint)
Authors: Wong Ka Po , Qin Jing
Published: April 2023

BACKGROUND

Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders among children. Children with ADHD have challenges in understanding social cues and behavioral problems when entering a social setting. Virtual reality (VR) has been applied to improve cognitive behaviors in children with ADHD. Previous studies have not adopted VR to improve social interaction competence and appropriateness in children with ADHD. VR offers a more effective alternative to therapeutic strategies for children with ADHD.

OBJECTIVE

This study aims to examine the feasibility and effectiveness of social VR training in enhancing social interaction skills compared to traditional social skills training in children with ADHD. We hypothesize that participants in the social VR training group are likely to perform better on social interaction skills than those in the traditional social skills training group.

METHODS

In this nonblinded, 3-arm randomized controlled trial (RCT), 90 participants with ADHD recruited from the community will be randomized 1:1:1 to the social VR intervention group, traditional social skills training group, or waitlist control group. The child psychiatrist will conduct assessments for each participant at baseline and after the intervention. The Social Skills Rating Scale–Parent will be used to assess the social interaction skills of the participants before and after the intervention. Participants in the social VR intervention group and traditional social skills training group will receive twelve 20-minute training sessions for 3 weeks. The participants in the waitlist control group will receive no training. The primary outcome measure is training acceptability and compliance. The secondary outcome measures are the child psychiatrist's assessment and the Social Skills Rating Scale–Parent before and after the intervention. Another outcome measure is the Behavior Rating Inventory of Executive Function and Attention. Differences in the scale scores will be examined using a t test and an F test.

RESULTS

This study is set to commence in the fourth quarter of 2023. It is anticipated that participants in the social VR intervention group will exhibit superior social interaction skills than those in the traditional social skills training group.

CONCLUSIONS

To our knowledge, this RCT is the first study examining the feasibility and effectiveness of a social VR-based intervention for enhancing the social interaction skills of children with ADHD in Hong Kong. The VR-based social skills training is expected to provide a safer and more effective environment for children with ADHD to learn than the traditional approach. This study can lead to a full-scale RCT.

CLINICALTRIAL

ClinicalTrials.gov NCT05778526; https://clinicaltrials.gov/study/NCT05778526

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/48208
Correlation between electronic Patient Reported Outcomes and biological markers, key parameter in acute radiation cystitis among prostate cancer patients: The prospective exploratory clinical study RABBIO (Preprint)
Authors: Helissey Carole , CAVALLERO Sophie , GUITARD Nathalie , THERY Hélène , PARNOT Charles , SCHERNBERG Antoine , AISSA Imen , RAFFIN Florent , LE COZ Catherine , MONDOT Stanislas , Christopoulos Christos , MALEK Karim , MALAURIE Emmanuelle , Blanchard Pierre , CHARGARI Cyrus , FRANCOIS Sabine
Published: April 2023

BACKGROUND

Despite advances in radiation techniques, radiation cystitis (RC) remains a significant cause of morbidity from pelvic radiotherapy, which may affect patients' quality of life (QoL). The pathophysiology of RC is not well understood, which limits the development of effective treatments.

OBJECTIVE

The RABBIO study aims to investigate the correlation between blood and urinary biomarkers and the intensity of acute RC symptoms and QoL in patients undergoing localized prostate cancer radiotherapy.

METHODS

The study included patients with low or intermediate-risk localized prostate cancer who were eligible for localized radiotherapy. Blood and urinary biomarkers were analyzed before radiotherapy was initiated and at weeks 4 and 12 of radiation therapy. Patients completed questionnaires related to radiation cystitis symptoms and QoL using a digital remote monitoring platform. The information was processed by means of an algorithm which classified patients according to the severity of symptoms and adverse events reported. Levels of blood and urinary biomarkers were correlated with the severity of acute RC symptoms and patient-reported QoL.

RESULTS

401 adverse events’ questionnaires were collected over the duration of the study. The most frequently reported adverse events at week 4 were pollakiuria, constipation, and diarrhea. In comparison with baseline, the mean Functional Assessment of Cancer Therapy-Prostate (FACT-P) score decreased at week 4. A significant polarization of M2-phenotype macrophages and increase in serum and urine levels of M-CSF, HGF, and MIP-1α over baseline were observed at week 12. Baseline serum and urine M-CSF concentrations showed a significant negative correlation with FACT–P scores at weeks 4 and 12.

CONCLUSIONS

The RABBIO study is the first to explore the overexpression of inflammatory proteins in fluid biopsies from patients with symptoms of acute RC. These preliminary findings suggest that serum and urine HGF, M-CSF, MIP-1α, as well as macrophage polarization are potential biomarkers of cystitis after prostate radiotherapy. The elevated M-CSF levels in serum and urine at baseline were associated with the deterioration of QoL during radiotherapy. The results of this study may help to develop mitigation strategies to limit radiation damage to the bladder.

CLINICALTRIAL

NCT05246774
Examining Real-World Medication Consultations and Drug-Herb Interactions: ChatGPT Performance Evaluation (Preprint)
Authors: Hsu Hsing-Yu , Hsu Kai-Cheng , Hou Shih-Yen , Wu Ching-Lung , Hsieh Yow-Wen , Cheng Yih-Dih
Published: April 2023

BACKGROUND

Since OpenAI released ChatGPT, with its strong capability in handling natural tasks and its user-friendly interface, it has garnered significant attention.

OBJECTIVE

A prospective analysis is required to evaluate the accuracy and appropriateness of medication consultation responses generated by ChatGPT.

METHODS

A prospective cross-sectional study was conducted by the pharmacy department of a medical center in Taiwan. The test data set comprised retrospective medication consultation questions collected from February 1, 2023, to February 28, 2023, along with common questions about drug-herb interactions. Two distinct sets of questions were tested: real-world medication consultation questions and common questions about interactions between traditional Chinese and Western medicines. We used the conventional double-review mechanism. The appropriateness of each response from ChatGPT was assessed by 2 experienced pharmacists. In the event of a discrepancy between the assessments, a third pharmacist stepped in to make the final decision.

RESULTS

Of 293 real-world medication consultation questions, a random selection of 80 was used to evaluate ChatGPT’s performance. ChatGPT exhibited a higher appropriateness rate in responding to public medication consultation questions compared to those asked by health care providers in a hospital setting (31/51, 61% vs 20/51, 39%; P=.01).

CONCLUSIONS

The findings from this study suggest that ChatGPT could potentially be used for answering basic medication consultation questions. Our analysis of the erroneous information allowed us to identify potential medical risks associated with certain questions; this problem deserves our close attention.
Особливості перебігу мозкових інфарктів у вагітних і породіль
Authors: Nehrych T.I. , Bozhenko N.L. , Negrych N.O. , Bozhenko M.I.
Published: April 2023

Актуальність. Цереброваскулярна хвороба, пов’язана з вагітністю, є серйозним ускладненням вагітності й післяпологового періоду. Етіологія і патологічні механізми цереброваскулярних захворювань у жінок є складними і включають зміни в серцево-судинній, ендокринній та імунній системах. Материнська смертність з причини інсульту становить 5–38 %. Залишковий неврологічний дефіцит спостерігається в 42–63 % пацієнток, які перенесли інсульт під час вагітності. У багатьох випадках ця проблема залишається недооціненою як лікарями, так і хворими, проте значною мірою впливає на якість їхнього життя. Мета: провести аналіз судинних подій у вагітних, які перебували на стаціонарному лікуванні в неврологічному відділенні Львівської обласної клінічної лікарні (ЛОКЛ) за річний період часу. Матеріали та методи. Виконано аналіз клінічних випадків хворих вагітних і породіллі, які перебували на стаціонарному обстеженні й лікуванні в неврологічному відділі ЛОКЛ. Результати. Розглянули судинні події у вагітних і породіллі, які перебували на стаціонарному лікуванні в неврологічному відділенні ЛОКЛ. Протягом річного періоду під нашим спостереженням перебували 3 пацієнтки: дві вагітні та одна породілля, у яких діагностовано різні варіанти ішемічного інсульту. Висновки. Мозковий інсульт — тяжке й небезпечне ускладнення при вагітності та пологах. Інсульт при вагітності розвивається нечасто, але значно збільшує материнську й перинатальну смертність. При підозрі на мозковий інсульт необхідне проведення нейровізуалізації (магнітно-резонансна томографія). Необхідно вжити заходів для запобігання інсульту в жінок за допомогою індивідуалізованого (пацієнтоцентрованого) підходу з координацією можливостей кількох спеціалістів, які включають численні індивідуальні стратегії для досягнення цільових результатів. Вчасна діагностика й правильне лікування вказаної категорії пацієнтів дозволить зменшити ризик виникнення повторного інсульту і знизити рівень інвалідизації пацієнтів. Профілактика інсульту має бути спрямована на жінок, з акцентом на тих, хто входить до групи ризику. Управління факторами ризику інсульту для жінок є aктивним процесом протягом усього життя.
I, You and the Others, among Otherness, Diversity and Education
Authors: Salum Tomé, PhD. José Manuel
Published: April 2023

When one thinks of the other and the other, they are not due to the sameness of power and hegemonies, and that this other is identified as a face, there remains the possibility of guiding behavior or ethics, along the paths of diversity, understood This is like the discovery of diversity and otherness in education, which are the most appropriate ways to understand that one’s own autonomy is in debt, under the figure of a hostage. Humanity has embarked on a path that has no possible reserve and this consists of opening, via postmodernity, a type of thought that is capable of generating recognition scenarios for what is different, as a discovery that greatly benefits everyone. Proposing that otherness is the basis on which diversity is built is already then an open path in education and to be followed that makes life have more meaning through the ethical recognition of the other and of the other who will accompany me in a path of history
The (Non) Influence of Monetary Incentives on Teacher Job Performance in Edo Central Senatorial District, Nigeria
Authors: Briscoe Patricia , Aiwuyo Oluranti M. , Iwuagwu Oselumese B.
Published: April 2023

In many developing countries Performance-Based Pay rewards (PBP) are a solution for improving teacher motivation. This study tested examines how teachers in Edo State, Nigeria felt about monetary incentives to increase job performance. Random sampling was used selecting a 20% sample of 164 of 820 teachers. Participants completed a questionnaire, and the data were analyzed using the Pearson Product Moment Correlation Coefficient. The study confirms no significant relationship between monetary incentives and teacher performance. Some possible explanations are provided and conclude that the use of monetary incentives in education in the state of Edo, Nigeria should be further reviewed.
Importancia de la Seguridad Física en la Infraestructura de Redes, Centros de Datos y Telecomunicaciones de las Instituciones de Educación Superior
Authors: de Jesús Díaz Novelo Carmen Humberta , Olmos de la Cruz Jaime
Published: April 2023

La infraestructura de las redes, los centros de datos y las telecomunicaciones de las Instituciones de Educación Superior (IES), permite el transporte de los datos y la interconexión hacia la red de redes (Internet). Por ello, es de vital importancia crear una conciencia desobre las acciones que las áreas estratégicas de Tecnologías de Información y Comunicación (TIC) deben tomar en lo referente a las inversiones y el otorgamiento de los recursos necesarios para asegurar la continuidad de los servicios, así como la implementación y el mantenimiento de sus proyectos. Se observa en las IES una necesidad apremiante por trabajar con un enfoque de gestión de riesgos, ya que, en cuanto a amenazas y vulnerabilidades a las que está expuesta la infraestructura, en todos los casos, el costo asociado a los riesgos no atendidos puede ser mucho mayor que el suficiente para implementar la protección requerida. Las metodologías de gestión de riesgos deben considerar las amenazas y las vulnerabilidades por fenómenos meteorológicos, ocasionadas por la geografía donde están ubicados los campus de las IES.
OPTIMIZED SPECTRAL ENERGY DISTRIBUTION FOR SEYFERT GALAXIES
Authors: Binette L. , Krongold Y. , Haro-Corzo S. A. R. , Humphrey A. , Morais S. G.
Published: April 2023

The temperature predicted by photoionization models for the narrow line region of Seyfert 2 galaxies is lower than the value inferred from the observed [OIII] λ4363Å/λ5007Å line ratio. We explore the possibility of considering a harder ionizing continuum than typically assumed. The spectral ionizing energy distribution, which can generate the observed λ4363Å/λ5007Å ratio, is characterized by a secondary continuum peak at 200 eV.
Posada, continuidad e innovación en la imagen impresa finisecular de México: litografía y fotolitografía
Authors: Bonilla Helia
Published: April 2023

En este artículo se explora, desde la especificidad de la historia de las artes gráficas en México y el rastreo de indicios técnicos, cómo fue que José Guadalupe Posada se posicionó respecto a los viejos y nuevos procedimientos de su oficio. Esto lleva a proponer que la primera técnica fotomecánica aplicada en su obra temprana en la Ciudad de México fue una novedosa modalidad de la fotolitografía; pero esta técnica no sería ejecutada por él, sino por un taller de origen francés que procesó ilustraciones para publicaciones diversas, entre ellas los semanarios La Patria Ilustrada, La Juventud Literaria y Revista de México, para los que trabajaron el propio Posada y otros de sus colegas. Asimismo, se muestra que él y quienes medraron del oficio de la imagen impresa en la capital vivieron en el fin de siglo una gradual transición; por una parte, las innovaciones técnicas en las artes gráficas, que eran también parte del discurso de calidad y modernidad de las publicaciones mexicanas que aspiraban a ponerse a la altura de sus prestigiadas congéneres extranjeras. Por otra parte, la permanencia de técnicas como la litografía tradicional, que continuaba utilizándose en el ámbito editorial en la última década del siglo XIX, y de la cual Posada siguió haciendo usufructo en su pequeño establecimiento, dos cuestiones que habían sido puestas en duda desde el supuesto de que por entonces, al igual que en Europa y Estados Unidos, la litografía era una técnica obsoleta en las publicaciones de México.
Reassessment of Geophysical Investigation of Zinc(Z), Cupper (Cu) and Lead (Pb) Potential Mineralization Deposits using Aeromagnetic Data in Wase Middle Benue Trough, Nigeria
Authors: Babagana Mustapha , Adamu Abubakar , Idris El-Yakub A. , Fatima Shehu M. , M Wase Muhammad , Muhammad Ibrahim M.. , Abba anko U. , Ahmed Hussain
Published: April 2023

Abstract: This effort aims to delineate structures responsible for exploring mineral resources in the Wase middle Benue trough area of Northcentral, Nigeria by evaluating the aeromagnetic data over that region. Oasis Montaj version 6.4 was used to qualitatively and quantitatively evaluate the aeromagnetic data. Techniques for Source Parameter Imaging (SPI) interpretation, including First Vertical Derivative, Analytical Signal, Upward Continuation, and Tilt Derivative, were used in the study. Analytic signal and tilt derivative maps showed different patterns of magnetic signatures independent of magnetization direction with amplitude ranging from 0.1 to 0.2nT/m and -1.3 to 1.4nT/m. They also showed qualitative interpretation applied aids enhance linear features at the expense of deep intrusive bodies like lineaments, fractures, and fault zones which trend Northeast Southwest (NE- SW) in the map of the study area. The boundaries of the geologically interesting anomalies were noticeably accentuated by the upward continuation done at 2 km. Nonetheless, this provides an approximation of the depth of the source of magnetic signatures in the area. The depth measured by SPI ranged from 103.9 to 1473.0 m. In the Eastern and Western regions of the region, respectively, shallow and deep-seated bodies are seen. The depth of the analysis was about 2000m, in conclusion, it was believed that the linear characteristics in the area that are trending northeast to southwest are possible structures for the prospecting of mineral deposits like zinc, copper, and lead
Human Symptoms Based on Diseases Predictor
Authors: Premalatha Mrs. M , Delipan G M. , Kavyashri V. , Sanjay S. , Srijayakanth K.
Published: April 2023

Abstract: Many situations occur in day to day life which affects a human being. Many problems are happening in fast manner and new diseases are rapidly being created. The main objective of this project is to apply classification algorithm to predict model for occurrence of various diseases. This project work is aimed in identifying the best classification algorithm to identify the disease probability of patients. The identification of the possibility of diseases in patients is a tedious task for doctors and researchers because it requires experience and more medical tests need to be taken. The main objective of this project is to find the best classification algorithm suitable to provide accuracy improvement during classification of normal and abnormal persons. The project contains Naïve Bayes, Support vector machine and decision tree classification with their accuracy score calculation. The applied NBS, SVM, DT classification help to predict the disease with higher accuracy in the new data set. Python 3.9 is used as the coding language.
Bone Tumor Detection and Classification Using Deep Learning
Authors: R Vishnuvardhan , G Balakrishnan , M Nithishkumar , S Logeshwaran
Published: April 2023

Abstract: Bone tumor is a rare type of tumor that refers to an abnormal growth of tissue inside and outside of the bone, with a high chance to spread to other parts of the body. A bone tumour is a mass growth of tumour cells that causes the disease and is difficult to diagnose. Children, teenagers, and young adults who have received a lot of radiation are the most affected. There are no known causes of bone cancer, unlike other cancers such those of the breast, lungs, prostate, stomach, and brain. Our project uses techniques like green plane extraction, arithmetic operations, linear contrast stretching, histogram equalization, and global thresholding to do segmentation, and GLCM is utilised for classification.
Big Data Stream Mining Using Integrated Framework with Classification and Clustering Methods
Authors: Nagasuresh Mr. M. , Roopa Ms. R.
Published: April 2023

Abstract: The causes of numerous sorts of big data and data stream problems include the quick development of industry firms, the vast amount of data generated by these innovations, and the exponential growth of industrial company websites. There are numerous stream data mining algorithms for classification and grouping, each with its own unique set of attributes and important features. Ensemble classifiers aid in enhancing the greatest prediction performance results from these cutting-edge techniques. Ensemble approaches teach multiple types of classifiers and clusters rather than a single classifier. Their machine learning prediction findings are merged to form a voting schedule. This research offered a framework for stream data mining based on miss categorization stream data, utilizing the advantages of assembly technology. Real-world data streams are used in experiments. The experimental results are compared to modern popular ensemble techniques such as Boosting and Bagging. The test results show an increase in accuracy rate and decrease in classification time.