bluuebunny/crossref_metadata_2025 huggingface dataset:
Techno-Environmental Assessment of Insulation Materials in Saudi Arabia: Integrating Thermal Performance and LCA
Authors: Alsaqabi Yazeed , Almhafdy Abdulbasit , Haider Husnain , Ghaffarianhoseini Amirhosein , Ghaffarianhoseini Ali , Ali Ahmed AbdelMonteleb M.
Published: January 2023

Arid and hot regions, like Saudi Arabia, utilize up to 60% of the country’s energy to regulate buildings’ indoor comfort. Energy efficiency is a long-term sustainability measure that is part of the government’s Vision 2030 strategy. A standard method of improving the thermal performance of buildings is through the use of insulation materials. Considering the cooling loads’ requirement and the Global Warming Potential (GWP), the present research evaluated the effectiveness of insulation materials, including extruded polystyrene, expanded polystyrene, rock wool, and glass wool in the hot, arid climate. For this case study, four similar villas facing the cardinal directions were selected from the residential project at Qassim University. HOBO data loggers were used to collect indoor temperature data. Thermal performance and Life Cycle Assessment (LCA) were conducted in accordance with Saudi Building Code-602 (SBC-602). Simulation outputs based on the four cardinal directions were used for assessing the thermal performance and LCA of the different thicknesses and densities of insulation materials. This was done using IESVE and SimaPro, IMPACR2002+, to assess their cooling load and GWP, respectively. The results suggest the potential for using lower insulation thickness for the northern and western façades without violating the SBC. The results obtained the actual thicknesses of the three insulation materials for achieving indoor temperatures in the four cardinal directions and the selection of materials and their densities along with associated GWP. The outputs of the study have been generalized in the form of a performance-based flowchart as a tool for selecting the type and thickness of thermal and environmental insulation in residential buildings in the Qassim region of Saudi Arabia.
Cost-Effective Heating Control Approaches by Demand Response and Peak Demand Limiting in an Educational Office Building with District Heating
Authors: Yuan Xiaolei , Vand Behrang , Martin Kristian , Jokisalo Juha , Liang Yumin , Kosonen Risto , Pan Yiqun
Published: January 2023

This study examined three different approaches to reduce the heating cost while maintaining indoor thermal comfort at acceptable levels in an educational office building, including decentralized (DDRC) and centralized demand response control (CDRR) and limiting peak demand. The results showed that although all these approaches did not affect the indoor air temperature significantly, the DDRC method could adjust the heating set point to between 20–24.5 °C. The DDRC approach reached heating cost savings of up to 5% while controlling space heating temperature without sacrificing the thermal comfort. The CDRC of space heating had limited potential in heating cost savings (1.5%), while the indoor air temperature was in the acceptable range. Both the DDRC and CDRC alternatives can keep the thermal comfort at good levels during the occupied time. Depending on the district heating provider, applying peak demand limiting of 35% can not only achieve 13.6% maximum total annual district heating cost saving but also maintain the thermal comfort level, while applying that of 43% can further save 16.9% of the cost, but with sacrificing a little thermal comfort. This study shows that demand response on heating energy only benefited from the decentralized control alternative, and the district heating-based peak demand limiting has significant potential for saving heating costs.
Development of Flash-Calcined Sediment and Blast Furnace Slag Ternary Binders
Authors: Zeraoui Ahmed , Maherzi Walid , Benzerzour Mahfoud , Abriak Nor , Aouad Georges
Published: January 2023

Partial cement replacement by low-carbon-impact additions has the potential to reduce CO2 emissions. The aim of this study is the development of a ternary binder that includes ordinary Portland cement (OPC), ground granulated blast furnace slag (GGBS), and flash-calcined sediment (FCS). To upgrade dredged mineral material into FCS, a new heat treatment, i.e., flash calcination, was used. The used materials were physically, chemically, and mineralogically characterized. The mixture design method was used to optimize the design of the ternary blended binders. A model was developed and validated for the prediction of the 90-day compressive strength for mortars composed of OPC (C), GGBS (S), and FCS (F). Five mixes, reference RM (100% OPC), binary mix (50% OPC and 50% GGBS), and three ternary mixes with FCS rates of 10%, 15%, and 20% were characterized in fresh and hardened states. The results show that the incorporation of FCS reduced the workability of the mixes and increased their densities. Moreover, the initial setting time of the mix was delayed, and the heat of the hydration peak was decreased. The 90-day compressive strengths of the mix containing 10% FCS were higher than those of RM. In conclusion, the use of 10% FCS and 40% GGBS was an efficient substitute for 50% OPC.
COVID and Cancer: A Complete 3D Advanced Radiological CT-Based Analysis to Predict the Outcome
Authors: Rahmanuddin Syed , Jamil Asma , Chaudhry Ammar , Seto Tyler , Brase Jordyn , Motarjem Pejman , Khan Marjaan , Tomasetti Cristian , Farwa Umme , Boswell William , Ali Haris , Guidaben Danielle , Haseeb Rafay , Luo Guibo , Marcucci Guido , Rosen Steven T. , Cai Wenli
Published: January 2023

Background: Cancer patients infected with COVID-19 were shown in a multitude of studies to have poor outcomes on the basis of older age and weak immune systems from cancer as well as chemotherapy. In this study, the CT examinations of 22 confirmed COVID-19 cancer patients were analyzed. Methodology: A retrospective analysis was conducted on 28 cancer patients, of which 22 patients were COVID positive. The CT scan changes before and after treatment and the extent of structural damage to the lungs after COVID-19 infection was analyzed. Structural damage to a lung was indicated by a change in density measured in Hounsfield units (HUs) and by lung volume reduction. A 3D radiometric analysis was also performed and lung and lesion histograms were compared. Results: A total of 22 cancer patients were diagnosed with COVID-19 infection. A repeat CT scan were performed in 15 patients after they recovered from infection. Most of the study patients were diagnosed with leukemia. A secondary clinical analysis was performed to show the associations of COVID treatment on the study subjects, lab data, and outcome on mortality. It was found that post COVID there was a decrease of >50% in lung volume and a higher density in the form of HUs due to scar tissue formation post infection. Conclusion: It was concluded that COVID-19 infection may have further detrimental effects on the lungs of cancer patients, thereby, decreasing their lung volume and increasing their lung density due to scar formation.
The Sesquiterpene Lactone-Rich Fraction of Inula helenium L. Enhances the Antitumor Effect of Anti-PD-1 Antibody in Colorectal Cancer: Integrative Phytochemical, Transcriptomic, and Experimental Analyses
Authors: Chun Jaemoo , Park Sang-Min , Lee Minsung , Ha In Jin , Jeong Mi-Kyung
Published: January 2023

Treatment strategies combining immune checkpoint inhibitors with sesquiterpene lactones have attracted much attention as a promising approach for cancer treatment. We systemically analyzed gene expression profiles of cells in response to two major sesquiterpene lactones, alantolactone and isoalantolactone, and determined whether the sesquiterpene lactone-rich fraction of Inula helenium L. (SFIH) enhances the antitumor effect of anti-PD-1 antibody in MC38 colorectal cancer-bearing mice. Gene expression and pathway analysis using RNA sequencing data were used to identify the SFIH-driven combined activity with anti-PD-1 antibody. The results showed that SFIH significantly enhanced the antitumor effect of anti-PD-1 antibody by reducing tumor growth and increasing the survival time of mice. Specifically, SFIH exhibited antitumor activity when combined with anti-PD-1 antibody, and the effects were further enhanced compared with monotherapy. An analysis of immune cells indicated that combination treatment with SFIH and anti-PD-1 antibody significantly increased the proportion of CD8+ T cells. Moreover, combination treatment enhanced antitumor immunity by decreasing the population of myeloid-derived suppressor cells and increasing the number of M1-like macrophages. Pathway enrichment analysis revealed that combination therapy activated immune-related pathways to a greater extent than monotherapy. In conclusion, our integrative analysis demonstrates that SFIH enhances the response of murine tumors to anti-PD-1 antibody. These findings provide insight into developing integrative therapeutics and molecular data for the use of natural products as an adjunct treatment for colorectal cancer.
Is the Social Gradient in Net Survival Observed in France the Result of Inequalities in Cancer-Specific Mortality or Inequalities in General Mortality?
Authors: Tron Laure , Remontet Laurent , Fauvernier Mathieu , Rachet Bernard , Belot Aurélien , Launay Ludivine , Merville Ophélie , Molinié Florence , Dejardin Olivier ,   Francim Group, Launoy Guy
Published: January 2023

Background: In cancer net survival analyses, if life tables (LT) are not stratified based on socio-demographic characteristics, then the social gradient in mortality in the general population is ignored. Consequently, the social gradient estimated on cancer-related excess mortality might be inaccurate. We aimed to evaluate whether the social gradient in cancer net survival observed in France could be attributable to inaccurate LT. Methods: Deprivation-specific LT were simulated, applying the social gradient in the background mortality due to external sources to the original French LT. Cancer registries’ data from a previous French study were re-analyzed using the simulated LT. Deprivation was assessed according to the European Deprivation Index (EDI). Net survival was estimated by the Pohar–Perme method and flexible excess mortality hazard models by using multidimensional penalized splines. Results: A reduction in net survival among patients living in the most-deprived areas was attenuated with simulated LT, but trends in the social gradient remained, except for prostate cancer, for which the social gradient reversed. Flexible modelling additionally showed a loss of effect of EDI upon the excess mortality hazard of esophagus, bladder and kidney cancers in men and bladder cancer in women using simulated LT. Conclusions: For most cancers the results were similar using simulated LT. However, inconsistent results, particularly for prostate cancer, highlight the need for deprivation-specific LT in order to produce accurate results.
Diagnostic and Therapeutic Pathway in Diffuse Malignant Peritoneal Mesothelioma
Authors: Kusamura Shigeki , Baratti Dario , De Simone Michele , Pasqual Enrico Maria , Ansaloni Luca , Marrelli Daniele , Robella Manuela , Accarpio Fabio , Valle Mario , Scaringi Stefano , Biacchi Daniele , Palopoli Carmen , Gazzanelli Sergio , Guaglio Marcello , Deraco Marcello
Published: January 2023

Diffuse malignant peritoneal mesothelioma (DMPM) is a rare form of mesothelioma that carries a very poor prognosis. The 5-year overall survival is about 20% (±5.9). Survival is optimal for patients suitable for cytoreductive surgery (CRS) with Hyperthermic Intraperitoneal Chemotherapy (HIPEC), with a median OS ranging from 34 to 92 months. However, selecting patients for surgery remains a complex task and requires a careful preoperative workup, rational analysis of prognostic profiles, and risk prediction models. Systemic chemotherapy could be offered: (1) in the adjuvant setting for high-risk patients; (2) for patients not eligible for CRS; and (3) for those with recurrent disease. It mainly includes the combination of Platin compound with Pemetrexed or immunotherapy. The biology of DMPM is still largely unknown. However, progress has been made on some fronts, such as telomere maintenance mechanisms, deregulation of apoptosis, tyrosine kinase pathways, and mutation of BRCA1-associated protein 1 (BAP1). Future perspectives should include translational research to improve our understanding of the disease biology to identify druggable targets. We should also clear the role of immune checkpoint inhibitors and investigate new locoregional technologies, such as pressurized intraperitoneal aerosol chemotherapy (PIPAC) or normothermic intraperitoneal chemotherapy (NIPEC).
A Global Perspective on Gastric Cancer Screening: Which Concepts Are Feasible, and When?
Authors: Januszewicz Wladyslaw , Turkot Maryla Helena , Malfertheiner Peter , Regula Jaroslaw
Published: January 2023

Background: Gastric cancer (GC) remains the fifth most common cancer and the third most common cause of cancer-related death globally. In 2022, GC fell into the scope of the updated EU recommendations for targeted cancer screening. Given the growing awareness of the GC burden, we aimed to review the existing screening strategies for GC in high-risk regions and discuss potentially applicable modalities in countries with low-to-intermediate incidence. Methods: The references for this Review article were identified through searches of PubMed with the search terms “gastric cancer”, “stomach cancer”, “Helicobacter pylori”, and “screening” over the period from 1995 until August 2022. Results: As Helicobacter pylori (H. pylori)-induced gastritis is the primary step in the development of GC, the focus on GC prevention may be directed toward testing for and treating this infection. Such a strategy may be appealing in countries with low- and intermediate- GC incidence. Other biomarker-based approaches to identify at-risk individuals in such regions are being evaluated. Within high-incidence areas, both primary endoscopic screening and population-based H. pylori “test-and-treat” strategies represent cost-effective models. Conclusions: Given the significant variations in GC incidence and healthcare resources around the globe, screening strategies for GC should be adjusted to the actual conditions in each region. While several proven tools exist for accurate GC diagnosis, a universal modality for the screening of GC populations remains elusive.
Peripubertal Nutritional Prevention of Cancer-Associated Gene Expression and Phenotypes
Authors: Brane Andrew , Arora Itika , Tollefsbol Trygve O.
Published: January 2023

Breast cancer (BC) is a nearly ubiquitous malignancy that effects the lives of millions worldwide. Recently, nutritional prevention of BC has received increased attention due to its efficacy and ease of application. Chief among chemopreventive compounds are plant-based substances known as dietary phytochemicals. Sulforaphane (SFN), an epigenetically active phytochemical found in cruciferous vegetables, has shown promise in BC prevention. In addition, observational studies suggest that the life stage of phytochemical consumption may influence its anticancer properties. These life stages, called critical periods (CPs), are associated with rapid development and increased susceptibility to cellular damage. Puberty, a CP in which female breast tissue undergoes proliferation and differentiation, is of particular interest for later-life BC development. However, little is known about the importance of nutritional chemoprevention to CPs. We sought to address this by utilizing two estrogen receptor-negative [ER(-)] transgenic mouse models fed SFN-containing broccoli sprout extract during the critical period of puberty. We found that this treatment resulted in a significant decrease in tumor incidence and weight, as well as an increase in tumor latency. Further, we found significant alterations in the long-term expression of cancer-associated genes, including p21, p53, and BRCA2. Additionally, our transcriptomic analyses identified expressional changes in many cancer-associated genes, and bisulfite sequencing revealed that the antiproliferation-associated gene Erich4 was both hypomethylated and overexpressed in our experimental group. Our study indicates that dietary interventions during the CP of puberty may be important for later-life ER(-) BC prevention and highlights potential important genetic and epigenetic targets for treatment and study of the more deadly variants of BC.
Advancing Pediatric Oncology Rehabilitation: Survey Findings of Health Professionals’ Perceptions of Barriers to Care and a Framework for Action
Authors: Ospina Paula A. , Pritchard Lesley , Eisenstat David D. , McNeely Margaret L.
Published: January 2023

Purpose: To explore pediatric oncology referral practices, gather healthcare providers’ perspectives of barriers to access and provision of rehabilitation service across Canada, and inform a framework for action to optimize rehabilitation care and inform future research. Methods: A cross-sectional survey was conducted with Canadian healthcare professionals (HCPs) working in pediatric oncology. Results: A total of 54 responses were received, and 34 corresponded to HCPs who refer children with cancer to rehabilitation services. Results suggest that approximately 25% of children are referred to rehabilitation services, primarily when the child presents with, or is at risk of, significant functional disability due to surgery. A primary barrier to service provision identified across HCPs included a lack of funding and resources. Medical professionals further identified a lack of specialized pediatric oncology rehabilitation services, whereas rehabilitation professionals identified the lack of pediatric oncology specific space and equipment. Identified themes from open-ended survey questions include the need for (1) dedicated funding and resources, (2) improved access, and (3) the need for specialized pediatric oncology rehabilitation services. Conclusion: Several barriers exist in the Canadian healthcare context that impact the delivery of rehabilitation services for children with cancer. We propose a framework for action to advance clinical care and guide future research.
One Step Catalytic Conversion of Polysaccharides in Ulva prolifera to Lactic Acid and Value-Added Chemicals
Authors: Li Mingyu , Zhou Yingdong , Hu Changwei
Published: January 2023

The production of lactic acid and value-added chemicals (such as hydroxypropanone, glycolic acid, and formic acid) directly from Ulva prolifera via one-step catalytic process was studied. The effect of different amounts of YCl3-derived catalysts on the hydrothermal conversion of carbohydrates in Ulva prolifera was explored, and the reaction conditions were optimized. In this catalytic system, rhamnose could be extracted from Ulva prolifera and converted in situ into lactic acid and hydroxypropanone at 160 °C, while all the glucose, xylose, and rhamnose were fractionated and completely converted to lactic acid at 220 °C or at a higher temperature, via several consecutive and/or parallel catalytic processes. The highest yield of lactic acid obtained was 31.4 wt% under the optimized conditions. The hydrothermal conversion of Ulva prolifera occurred rapidly (within 10 min) and showed promise to valorize Ulva prolifera.
Guaiacol to Aromatics: Efficient Transformation over In Situ-Generated Molybdenum and Tungsten Oxides
Authors: Mukhtarova Mariyam , Golubeva Maria , Sadovnikov Alexey , Maximov Anton
Published: January 2023

The development of catalysts for the hydrodeoxygenation of bio-based feedstocks is an important step towards the production of fuels and chemicals from biomass. This paper describes in situ-generated bulk molybdenum and tungsten oxides in the hydrodeoxygenation of the lignin-derived compound guaiacol. The catalysts obtained were studied using powder X-ray diffraction, X-ray photoelectron spectroscopy, scanning electron microscopy, high-resolution transition electron microscopy, diffuse reflectance infrared Fourier transform spectroscopy, and Raman spectroscopy. The use of metal carbonyls as precursors was shown to promote the formation of amorphous molybdenum oxide and crystalline tungsten phosphide under hydrodeoxygenation conditions. The catalysts’ activity was investigated under various reaction conditions (temperature, H2 pressure, solvent). MoOx was more active in the partial and full hydrodeoxygenation of guaiacol at temperatures of 200–380 °C (5 MPa H2, 6 h). However, cyclohexane, which is an undesirable product, was formed in significant amounts using MoOx (5 MPa H2, 6 h), while WOx was more selective to aromatics. When using dodecane as a solvent (380 °C, 5 MPa H2, 6 h), the benzene-toluene-xylenes fraction was obtained with a 96% yield over the WOx catalyst.
Macrophages Promote Ovarian Cancer-Mesothelial Cell Adhesion by Upregulation of ITGA2 and VEGFC in Mesothelial Cells
Authors: Cho Seung-Kye , Lee Kijun , Woo Jeong-Hwa , Choi Jung-Hye
Published: January 2023

Ovarian cancer is a metastatic disease that frequently exhibits extensive peritoneal dissemination. Recent studies have revealed that noncancerous cells inside the tumor microenvironment, such as macrophages and mesothelial cells, may play a role in ovarian cancer metastasis. In this study, we found that human ovarian cancer cells (A2780 and SKOV3) adhered more to human mesothelial Met5A cells stimulated by macrophages (M-Met5A) in comparison to unstimulated control Met5A cells. The mRNA sequencing revealed that 94 adhesion-related genes, including FMN1, ITGA2, COL13A1, VEGFC, and NRG1, were markedly upregulated in M-Met5A cells. Knockdown of ITGA2 and VEGFC in M-Met5A cells significantly inhibited the adhesion of ovarian cancer cells. Inhibition of the JNK and Akt signaling pathways suppressed ITGA2 and VEGFC expression in M-Met5A cells as well as ovarian cancer-mesothelial cell adhesion. Furthermore, increased production of CC chemokine ligand 2 (CCL2) and CCL5 by macrophages elevated ovarian cancer-mesothelial cell adhesion. These findings imply that macrophages may play a significant role in ovarian cancer-mesothelial cell adhesion by inducing the mesothelial expression of adhesion-related genes via the JNK and Akt pathways.
Genes Involved in DNA Repair and Mitophagy Protect Embryoid Bodies from the Toxic Effect of Methylmercury Chloride under Physioxia Conditions
Authors: Augustyniak Justyna , Kozlowska Hanna , Buzanska Leonora
Published: January 2023

The formation of embryoid bodies (EBs) from human pluripotent stem cells resembles the early stages of human embryo development, mimicking the organization of three germ layers. In our study, EBs were tested for their vulnerability to chronic exposure to low doses of MeHgCl (1 nM) under atmospheric (21%O2) and physioxia (5%O2) conditions. Significant differences were observed in the relative expression of genes associated with DNA repair and mitophagy between the tested oxygen conditions in nontreated EBs. When compared to physioxia conditions, the significant differences recorded in EBs cultured at 21% O2 included: (1) lower expression of genes associated with DNA repair (ATM, OGG1, PARP1, POLG1) and mitophagy (PARK2); (2) higher level of mtDNA copy number; and (3) higher expression of the neuroectodermal gene (NES). Chronic exposure to a low dose of MeHgCl (1 nM) disrupted the development of EBs under both oxygen conditions. However, only EBs exposed to MeHgCl at 21% O2 revealed downregulation of mtDNA copy number, increased oxidative DNA damage and DNA fragmentation, as well as disturbances in SOX17 (endoderm) and TBXT (mesoderm) genes expression. Our data revealed that physioxia conditions protected EBs genome integrity and their further differentiation.
Adopting a Statistical, Mechanistic, Integrated Surveillance, Thermal Biology, and Holistic (SMITH) Approach for Arbovirus Control in a Changing Climate: A Review of Evidence
Authors: Oladipo Habeebullah Jayeola , Tajudeen Yusuf Amuda , Oladunjoye Iyiola Olatunji , Mustapha Sheriff Taye , Sodiq Yusuff Inaolaji , Yusuf Rashidat Onyinoyi , Egbewande Oluwaseyi Muyiwa , Muili Abdulbasit Opeyemi , Adigun Taofeekat Oluwatosin , Taiwo Emmanuel O. , El-Sherbini Mona Said
Published: January 2023

Arbovirus control depends on accurate projections of likely changes in the arthropod vector species, essential to inform local and global public health authorities. According to the WHO Assembly and the Global Vector Control Response (GVCR), by 2030, the burden of vector-borne diseases, particularly arbovirus infections, is expected to be greatly decreased. However, anthropogenic drivers, including climate change, insecticide resistance, and a lack of operational local databases for risk management of emerging and re-emerging arboviruses, hinders effective implementation plans. This article presents a statistical, mechanistic, integrated surveillance, thermal biology, and holistic framework (termed SMITH) to discuss how temperature variations affect the biological transmission, replication, extrinsic incubation period, nutritional behavior, distribution, and survival (TRENDS) of arboviruses. Future transdisciplinary research that involves knowledge translation between local and global communities is required for early detection and risk management of the growing threat posed by arboviruses for human, animal, and planetary health.
HS-SPME-GC/MS Method for the Simultaneous Determination of Trihalomethanes, Geosmin, and 2-Methylisoborneol in Water Samples
Authors: Pardina Diego , Santamaria Asier , Alonso María Luz , Bartolomé Luis , Alonso Rosa M. , Maña Jon Ander , Bilbao Elisabeth , Lombraña Jose Ignacio , Bartolome Mikel , Hernando Luis M.
Published: January 2023

Drinking water treatment plants (DWTP) use chlorination as an oxidation stage in the first step of the processes used to eliminate the natural organic matter (NOM) responsible for the formation of 2-methylisoborneol (2-MIB) and Geosmin (GM), which produce odor and taste to the water. However, chlorination processes give rise to disinfectant toxic subproducts, such as trihalomethanes (THMs). In this work, a headspace solid-phase microextraction coupled with a gas chromatography/mass spectrometric method has been developed for the quality control of drinking water. 2-MIB, GM, and THMs at different stages of the drinking water treatment process were monitored. The method was validated following the Environmental Protection Agency guidelines. Neither carryover nor the matrix effect was observed. The performance of the method was satisfactory in terms of selectivity, repeatability, and accuracy and exhibited a linear concentration range of 0.8–50 µg/L for trichloromethane (TCM), 0.05–20 µg/L for bromodichloromethane, 0.01–20 µg/L for dibromochloromethane and tribromomethane, and 0.005–0.05 µg/L for GM and 2-MIB. The THMs concentration obtained for all the water samples was below the thresholds established by international organizations and, for 2-MIB and GM, were lower for their limit of quantification. The method was also applied to the adsorption kinetic study of TCM on granulated activated carbon, which is the main barrier to reducing the NOM in DWTP.
Localization and Laparoscopic Excision of Gastric Heterotopic Pancreas in a Child by Endoscopic SPOT® Tattooing
Authors: Liou Yu-Jung , Weng Shu-Chao , Chang Paul Chia-Yu , Jiang Chuen-Bin , Lee Hung-Chang , Chan Wai-Tao , Ho Cheng-Yu , Wu Pao-Shu , Yeung Chun-Yan
Published: January 2023

Heterotopic pancreas (HP) is defined as pancreatic tissue lacking vascular or anatomic connection with the normal pancreas. Surgical resection is often indicated for symptomatic gastric HP. However, intraoperative identification of gastric HP is often difficult during laparoscopic surgery. Herein, we describe a patient with gastric HP, which was marked with SPOT® dye (GI Supply, Camp Hill, PA, USA). The dye was seen clearly laparoscopically facilitating total excision of the lesion. The final pathology report confirmed the presence of heterotopic pancreatic tissue including pancreatic acini, small pancreatic ducts tissue with islets of Langerhans in the deep gastric submucosal area. There were no postoperative complications, and the patient was symptom-free. To the best of our knowledge, this was the first case report in the literature in which endoscopic tattooing of gastric HP before laparoscopic resection was performed. This method of localization was simple and reliable in children.
Consideration of Unidirectional Cyclic Loading on Bond in Reinforced Lightweight Concrete in Standards
Authors: Gyurkó Zoltán , Kovács Tamás , Jakab Levente , Nemes Rita
Published: January 2023

The present research deals with the cyclic and standard pull-out resistance of deformed steel bars embedded in lightweight and normal concrete. This paper is a continuation of a previous paper, where the experimental results are detailed. In the present paper, the experimental results are set against the formulas and the diagrams provided by the Eurocode standard and the Model Code 1990, and then a comparative discussion is performed. In the case of cyclic loading, the damage defined by the Palmgren–Miner hypothesis, as well based on the recommendations of various national annexes of Eurocode and the Model Code, is calculated. A multiplier corresponding to the maximum load is calculated, which indicates by how much the applied load should be multiplied to obtain a damage value equal to 1.
Synthesis of Metal Organic Frameworks (MOFs) and Their Derived Materials for Energy Storage Applications
Authors: Dutt Sunil , Kumar Ashwani , Singh Shivendra
Published: January 2023

The linkage between metal nodes and organic linkers has led to the development of new porous crystalline materials called metal–organic frameworks (MOFs). These have found significant potential applications in different areas such as gas storage and separation, chemical sensing, heterogeneous catalysis, biomedicine, proton conductivity, and others. Overall, MOFs are outstanding candidates for next-generation energy storage devices, and they have recently attracted the greater devotion of the scientific community worldwide. MOFs can be used to enhance the ability of a device to store energy due to their unique morphology, controllable structures, high surface area, and permanent porosity. MOFs are widely used in super capacitors (SCs), metal (Li, Na, and K) ion batteries, and lithium–sulfur batteries (LSBs) and act as a promising candidate to store energy in an environmentally friendly way. MOFs are also used as efficient materials with better recyclability, efficiency, and capacity retention. In this review, first we summarize the material design, chemical compositions, and physical structure of MOFs and afterward, we highlight the most recent development and understanding in this area, mainly focusing on various practical applications of MOFs in energy storage devices.
The Changing Nature of Hazardous Weather and Implications for Transportation: Example from Oklahoma, USA
Authors: Mullens Esther , McPherson Renee
Published: January 2023

Central Oklahoma is undergoing investment in new intermodal transportation and rehabilitation of its infrastructure. Despite a highly variable historical climate, future changes resulting from anthropogenic climate change may be outside of the range for which infrastructure was designed. We examined 21st century trends, focusing on weather and climate extremes of demonstrated importance to transportation professionals as identified through expert input. We assessed trends from a suite of 15 global climate models (GCMs) using two emissions scenarios and two high-resolution statistically downscaled datasets. This ensemble provided a quantitative range for potential future climate conditions whilst revealing uncertainties associated with different models and downscaling methods. Our results support the general consensus of a reduction in the frequency of cold temperatures, freeze–thaw cycles, and winter weather; however, for the latter, there is not necessarily a reduction in intensity. Extreme heat days (e.g., days ≥100 °F) increased by factors of 3–6, with this upper range associated with high greenhouse gas emissions, while the seasonal duration of extreme heat extended by 4–10 weeks. Projected return intervals for heavy rainfall increased in frequency and magnitude in the mid and late 21st century. Although the contribution of the emissions pathway to these changes is evident, different extreme value distributions and the varying simulations of precipitation from the GCMs have a large effect on magnitudes, leading to a range of possible futures to consider in infrastructure design. Precipitation metrics, particularly at the extremes, were more sensitive to the selection of downscaled data, as compared with temperature metrics. Our approach represents a resource for transportation professionals seeking to identify changing risk probabilities at regional to local scales, as a precursor to planning and adaptation.
Thickness Debit Effect in Creep Performance of a Ni3Al-Based Single-Crystal Superalloy with [001] Orientation
Authors: Zhang Shuangqi , Ma Guoquan , Wang Haibo , Guo Wenqi , Zhao Haigen , Shang Yong , Pei Yanling , Li Shusuo , Gong Shengkai
Published: January 2023

With the complexity of the structure of aero-engine turbine blades, the blade wall thickness continues to decrease. It is found that when the blade wall thickness decreases to a certain extent, its mechanical properties will decline significantly. It is extremely important to study this phenomenon of a significant decline in mechanical properties caused by wall thickness. In this paper, the creep behavior of a second-generation Ni3Al-based single crystal superalloy with different wall thicknesses and [001] orientation at 980 °C/220 MPa has been studied and compared with the creep life of Φ4 round bar. The experimental results show that the second orientation and the surface affected zone are not the main reasons for the reduction of the life of thin-walled samples under this experimental condition. By analyzing the fracture morphology and deformed microstructure of thin-walled samples with different thicknesses, it is found that the thickness debit effect of the single crystal alloy occurs since the effective stress area of the alloy changes due to internal defects and surface affected zone during the creep process. For thicker samples, the creep life of the alloy can be extended by making the samples undergo certain plastic deformation through better plastic deformation coordination ability, while for thinner samples, the plastic coordination ability is poor, and the ability to extend the creep life through plastic deformation is also weaker when the effective stress area of the alloy changes, which leads to the thinner samples being more prone to fracture.
Supramolecular Assemblies in Pyridine- and Pyrazole-Based Coordination Compounds of Co(II) and Ni(II): Characterization, Hirshfeld Analysis and Theoretical Studies
Authors: Baishya Trishnajyoti , Gomila Rosa M. , Barceló-Oliver Miquel , Gil Diego M. , Bhattacharyya Manjit K. , Frontera Antonio
Published: January 2023

Two new Ni(II) and Co(II) coordination compounds, viz., [Ni(H2O)5(DMAP)](IPhth)·2H2O (1) and [Co(Hdmpz)4(H2O)2]Cl2 (2) (where DMAP = 4-dimethylaminopyridine, IPhth = Isophthalate, Hdmpz = 3,5-dimethylpyrazole),were synthesized and characterized using elemental analysis, TGA, spectroscopic (FTIR and electronic) and single-crystal X-ray diffraction techniques. Compound 1 crystallizes as a co-crystal hydrate of Ni(II), whereas compound 2 is a mononuclear compound of Co(II). The crystal structure analysis of compound 1 reveals the presence of various non-covalent interactions such as anion–π, π–π, C–H∙∙∙π, C–H∙∙∙C, etc., which stabilize the layered assembly of the compound. In compound 2, enclathration of counter chloride ions within the supramolecular trimeric host cavity plays a crucial role in the stabilization of the compound. The non-covalent interactions observed in the crystal structures were further studied theoretically, focusing on the cooperative π-stacking interactions between the DMAP and IPhth counter-ions in 1. To identify the non-covalent interactions of the compounds, Hirshfeld surfaces and their associated two-dimensional fingerprint regions were analyzed. Theoretical calculations confirm that H-bonding interactions combined with the π-stacking contacts are crucial synthons for the solid-state stability of compound 1.
Phosphorus Recovery from Municipal Wastewater: Brucite from MgO Hydrothermal Treatment as Magnesium Source
Authors: Natsi Panagiota D. , Goudas Konstantinos-Anastassios , Koutsoukos Petros G.
Published: January 2023

Crystallization of struvite (MgNH4PO4·6H2O, MAPH) for both N and P recovery from municipal wastewater is an attractive alternative. The low magnesium concentration in municipal wastewater calls for low-cost magnesium sources. In the present work, the precipitation of struvite from supersaturated solutions was investigated. The supersaturated solutions were prepared by the addition of either slurry of Mg(OH)2 (brucite) obtained from the hydrothermal treatment of magnesium oxide (MgO) or using the aqueous solution equilibrated with brucite after separation from the solid. In both cases, in the supersaturated solutions prepared by the addition of ammonium dihydrogen phosphate, the Mg:NH4:P ratio was 1:1:1, pH 7.0–11.0. The apparent order for the precipitation suggested that the dominant mechanism was surface diffusion according to the polynuclear model. The apparent rate constant for struvite precipitation was two orders of magnitude smaller for the slurry prepared supersaturated solution in comparison with the respective prepared from the brucite-equilibrated solution. Simulated wastewater (SWW), was supersaturated with respect to struvite, by inoculation with brucite. The apparent rate constant was two orders of magnitude higher than that corresponding to the supersaturated solutions prepared by the addition of solution equilibrated with brucite. The P recovery from SWW reached 70%.
A Review of the Asexual Mite Genus Paralycus Womersley, 1944 (Acari: Oribatida: Pediculochelidae), with Description of Three New Species and A Key to Species of the World
Authors: Kolesnikov Vasiliy B. , OConnor Barry , Ermilov Sergey G. , Klimov Pavel B.
Published: January 2023

Mites of the genus Paralycus (Oribatida: Pediculochelidae) are minute, asexual, paedomorphic oribatids that have been largely overlooked by major biodiversity surveys. Here, we review this genus and describe three new species based on adult females: Paralycus persephone sp. n. and Paralycus daeira sp. n. from deep soil in Colorado, USA and Paralycus pricei sp. n. from South Africa. We provide the first complete ontogenetic series in the family using P. daeira sp. n. as a model, clarify the species boundaries in several species, and compile an annotated checklist and key to species of Paralycus of the World. Our work suggests that the pediculochelid biodiversity is underappreciated as these mites may be common in subterranean habitats/deep soil. Further discoveries of the Paralycus diversity in these habitats are anticipated.
Clinical Applications of B-Flow Ultrasound: A Scoping Review of the Literature
Authors: Hofmann Amun G. , Mlekusch Irene , Wickenhauser Georg , Assadian Afshin , Taher Fadi
Published: January 2023

Coded excitation ultrasound investigations have the potential to augment the resolution, increase the efficiency, and expand the possibilities of noninvasive diagnostic imaging. B-Flow ultrasound, a type of digitally encoded imaging, was developed more than 20 years ago with the aim to optimize the visualization of blood flow. It has been investigated for a plethora of applications so far. A scoping review regarding its clinical applications was conducted based on a systematic literature research. B-Flow has been investigated in various anatomic locations and pathologies. However, previous research is limited by small sample sizes, the rare occurrence of elaborate study designs, the reliance on subjective reports and qualitative data, as well as several potential biases. While results are in general promising, it should therefore still be considered an emerging technology. Nevertheless, the limitations can be addressed in future research and the potential to expand its applications make B-Flow an interesting candidate for further investigations.
Computer-Aided Diagnosis System for Blood Diseases Using EfficientNet-B3 Based on a Dynamic Learning Algorithm
Authors: Abd El-Ghany Sameh , Elmogy Mohammed , El-Aziz A. A. Abd
Published: January 2023

The immune system’s overproduction of white blood cells (WBCs) results in the most common blood cancer, leukemia. It accounts for about 25% of childhood cancers and is one of the primary causes of death worldwide. The most well-known type of leukemia found in the human bone marrow is acute lymphoblastic leukemia (ALL). It is a disease that affects the bone marrow and kills white blood cells. Better treatment and a higher likelihood of survival can be helped by early and precise cancer detection. As a result, doctors can use computer-aided diagnostic (CAD) models to detect early leukemia effectively. In this research, we proposed a classification model based on the EfficientNet-B3 convolutional neural network (CNN) model to distinguish ALL as an automated model that automatically changes the learning rate (LR). We set up a custom LR that compared the loss value and training accuracy at the beginning of each epoch. We evaluated the proposed model on the C-NMC_Leukemia dataset. The dataset was pre-processed with normalization and balancing. The proposed model was evaluated and compared with recent classifiers. The proposed model’s average precision, recall, specificity, accuracy, and Disc similarity coefficient (DSC) were 98.29%, 97.83%, 97.82%, 98.31%, and 98.05%, respectively. Moreover, the proposed model was used to examine microscopic images of the blood to identify the malaria parasite. Our proposed model’s average precision, recall, specificity, accuracy, and DSC were 97.69%, 97.68%, 97.67%, 97.68%, and 97.68%, respectively. Therefore, the evaluation of the proposed model showed that it is an unrivaled perceptive outcome with tuning as opposed to other ongoing existing models.
Deep Learning Architecture for UAV Traffic-Density Prediction
Authors: Alharbi Abdulrahman , Petrunin Ivan , Panagiotakopoulos Dimitrios
Published: January 2023

The research community has paid great attention to the prediction of air traffic flows. Nonetheless, research examining the prediction of air traffic patterns for unmanned aircraft traffic management (UTM) is relatively sparse at present. Thus, this paper proposes a one-dimensional convolutional neural network and encoder-decoder LSTM framework to integrate air traffic flow prediction with the intrinsic complexity metric. This adapted complexity metric takes into account the important differences between ATM and UTM operations, such as dynamic flow structures and airspace density. Additionally, the proposed methodology has been evaluated and verified in a simulation scenario environment, in which a drone delivery system that is considered essential in the delivery of COVID-19 sample tests, package delivery services from multiple post offices, an inspection of the railway infrastructure and fire-surveillance tasks. Moreover, the prediction model also considers the impacts of other significant factors, including emergency UTM operations, static no-fly zones (NFZs), and variations in weather conditions. The results show that the proposed model achieves the smallest RMSE value in all scenarios compared to other approaches. Specifically, the prediction error of the proposed model is 8.34% lower than the shallow neural network (on average) and 19.87% lower than the regression model on average.
A Textual Backdoor Defense Method Based on Deep Feature Classification
Authors: Shao Kun , Yang Junan , Hu Pengjiang , Li Xiaoshuai
Published: January 2023

Natural language processing (NLP) models based on deep neural networks (DNNs) are vulnerable to backdoor attacks. Existing backdoor defense methods have limited effectiveness and coverage scenarios. We propose a textual backdoor defense method based on deep feature classification. The method includes deep feature extraction and classifier construction. The method exploits the distinguishability of deep features of poisoned data and benign data. Backdoor defense is implemented in both offline and online scenarios. We conducted defense experiments on two datasets and two models for a variety of backdoor attacks. The experimental results demonstrate the effectiveness of this defense approach and outperform the baseline defense method.
Pattern Reconstruction from Near-Field Data Affected by 3D Probe Positioning Errors Collected via Planar-Wide Mesh Scanning
Authors: Bevilacqua Florindo , D’Agostino Francesco , Ferrara Flaminio , Gennarelli Claudio , Guerriero Rocco , Migliozzi Massimo , Riccio Giovanni
Published: January 2023

An effective procedure to correct known 3D probe positioning errors affecting the near-field–far-field transformation (NF–FF) with non-conventional plane rectangular scanning, named planar wide-mesh scanning (PWMS), is developed in this paper. It relies on the non-redundant sampling representations of electromagnetic fields and related optimal sampling interpolation (OSI) expansions and has been devised when a quasi-planar antenna under test is considered as suitably modelled by either a double bowl or an oblate spheroid. Such an algorithm first makes use of the so-called k-correction to compensate for the errors occurring when the actual sampling points deviate from the acquisition plane and then adopts an iterative procedure to restore the NF samples at the points specified by the used non-redundant sampling representation from those obtained at the previous step and affected by 2D positioning errors. Finally, once the regularly arranged PWMS samples have been calculated, the NF data required to compute the classic plane-rectangular NF–FF transformation are accurately evaluated by using an effective 2D OSI algorithm. Several numerical results are presented in order to assess the effectiveness of the devised approach.
Side-Channel Attack of Lightweight Cryptography Based on MixColumn: Case Study of PRINCE
Authors: Xue Jizheng , Jiang Xiaowen , Li Peng , Xi Wei , Xu Changbao , Huang Kai
Published: January 2023

Lightweight cryptography is implemented in unrolled architecture generally, which has the characteristics of low latency and high real-time performance but also faces the threat of Side-Channel Attack (SCA). Different from traditional loop architecture, the unrolled architecture requires separate protection against SCA in each round. This leads to the unrolled architecture that is very sensitive to the number of rounds that need to be protected against SCA. In this paper, we propose an optimized method for the chosen-input attack that can effectively increase the number of rounds of differential propagation and recover the key from the fourth round of unrolled PRINCE for the first time. This research also evaluates the hardware overhead and performance of two types of Threshold implementation (TI) for PRINCE. The experimental results indicate that TI imposes substantial hardware overhead on the circuit, therefore a specified number of protection rounds is required.