bluuebunny/crossref_metadata_2025 huggingface dataset:
SISTEM REGULASI DAN KEBIJAKAN PERPAJAKAN DI INDONESIA PERSPEKTIF EKONOMI ISLAM
Authors: Wartoyo Wartoyo
Published: November 2019

Tax is a fiscal instrument in macroeconomic theory that can be used by the government to make funding (budgetary function) and regulation (regurelend function) in overcoming economic turmoil that always occurs in a country. The taxation system in Indonesia continues to change to adjust to the conditions and economic trends that occur in the world, so it is not surprising that there have been several tax reforms, including the birth of the Final PPH policy, Sunset Policy and Tax Amnesty. The goal is nothing but to adjust the needs of the rules to the real conditions that occur in the world economy and also in society so that state revenues from the tax sector can be fulfilled and in accordance with the targets mandated by the APBN. In Islamic economics itself tax is not something foreign, because it has been practiced since the beginning of Islamic rule where there were various kinds of taxes applied such as zakat, kharaj, khums, jizyah and so on. in the dialectic of taxes and alms there are two thoughts that arise, first is that which punishes taxes as zakat and second is that which still distinguishes the two. This difference has basically found a meeting point with the integration of zakat as a tax deduction that can be accepted by all levels of society in Indonesia.
Arthur Bliss' Scores for Robert Helpmann: Musical Responses to Ambitious Creative Challenges
Authors: Durà-Vilà Víctor
Published: November 2019

In this article, I explain the demanding creative challenges that Robert Helpmann had to face regarding Miracle in the Gorbals (1944) and Adam Zero (1946) by examining the difficulties presented by the concepts behind the scenarios and Helpmann's own artistic commitments. In relation to the reception of these ballets, I explore the controversies surrounding Helpmann's choices of subject matter as well as the perceived imbalance between the theatrical and the choreographic aspects of these works. I argue that Arthur Bliss' scores for both ballets show him as an ideal collaborator for Helpmann. Bliss' creative personality made him a sympathetic and effective composer for these ballets, given their dramatic requirements. Finally, I contend that only an awareness of the theatrical reality of these ballets will allow us a proper assessment of Bliss' scores for Helpmann.
Revaluations through Dance: Friedrich Nietzsche's Thought in Isadora Duncan's Speech The Dance of the Future
Authors: Peters Meindert E.
Published: November 2019

Friedrich Nietzsche's influence on Isadora Duncan's work, in particular his idea of the Dionysian, has been widely discussed, especially in regard to her later work. What has been left underdeveloped in critical examinations of her work, however, is his influence on her earlier choreographic work, which she defended in a famous speech held in 1903 called The Dance of the Future. While commentators often describe this speech as ‘Nietzschean’, Duncan's autobiography suggests that she only studied Nietzsche's work after this speech. I take this incongruity as a starting point to explore the connections between her speech and Nietzsche's work, in particular his Thus Spoke Zarathustra. I argue that in subject and language Duncan's speech resembles Nietzsche's in important ways. This article will draw attention to the ways in which Duncan takes her cues from Nietzsche in bringing together seemingly conflicting ideas of religion and an overturning of morality; Nietzsche's notion of eternal recurrence and the teleology present in his idea of the Übermensch; and a renegotiation of the body's relation to the mind. In doing so, this article contributes not only to scholarship on Duncan's early work but also to discussions of Nietzsche's reception in the early twentieth century. Moreover, the importance Duncan ascribes to the body in dance and expression also asks for a new understanding of Nietzsche's own way of expressing his philosophy.
ANALISIS KONFLIK DALAM IMPLEMENTASI KEBIJAKAN TATA RUANG WILAYAH DI PEMBANGUNAN PARIWISATA BERKELANJUTAN DI KAWASAN GEOPARK RINJANI-LOMBOK, PROVINSI NUSA TENGGARA BARAT
Authors: Bachry Johan
Published: November 2019

Regional Regulation No.3 of 2010 was implemented, how the conflict was and its solutions and how a conflict resolution model was found and recommended to be implemented. This research uses descriptive, exploratory and participatory methods with qualitative and quantitative approaches. Data collected by interviewing informants and respondents as well as observing and documenting. The data analyzed by: Overlay map analysis, descriptive analysis, and scoring analysis.The result of this study are: 1) It is known that the implementation level of spatial policy is at a fairly good level based on an assessment of the four aspects mentioned by George Edward III namely communication, bureaucratic structure, disposition, and resources. 2) Several types of conflicts were found, namely conflicts over spatial use (spacial conflicts) and conflicts of authority. 3) Conflict resolution models carried out by the implementor in implementing Regional Regulation on Spatial Planning, namely legalicy model, persuasive/negotiation model, demolition model, socio-cultural approach model, coordination and synchronization model. 4) Researcher formulate an integrative-participatory solution model to resolve conflicts in spatial policy implementation in the Geopark Rinjani Lombok Area. This study also analyzed the implications of the results of the research on the conflict theory proposed by Johan Galtung
PENGARUH PENAMBAHAN SERBUK ECENG GONDOK TERHADAP KUAT TEKAN BETON
Authors: Hadi Surya
Published: November 2019

Beton merupakan bahan bangunan yang terbuat dari campuran agregat dan pengikat semen. Bentuk paling umum dari beton adalah beton semen Portland, yang terdiri dari agregat mineral (biasanya kerikil dan pasir), semen dan air. Dengan penambahan serbuk eceng gondok pada campuran beton diharapkan bisa menghasilkan beton dengan nilai kuat tekan yang lebih tinggi dibandingkan dengan beton normal. Pada penelitian ini dilakukan pengujian dengan metode destruktif. Pengujian ini bertujuan untuk mengetahui kuat tekan yang ditambahkan dengan serbuk enceng gondok pada beton yang selanjutnya akan dibandingkan dengan beton normal. Pada penelitian dengan tambahan serbuk eceng gondok dipadatkan dengan alat penumbuk. Benda uji berbentuk silinder dengan ukuran diameter 150 mm dan tinggi 300 mm sebanyak 24 buah dengan kuat tekan rencana 25 Mpa. Kadar serbuk eceng gondok yang ditambahkan pada beton sebesar 0%, 2 %, 4%, dan 6%. Pengujian ini dilakukan setelah beton berumur 28 hari. Prosedur penelitian dilakukan dengan metode destruktif menggunakan alat Compression Testing Machine (CTM). Dari hasil penelitian diperoleh kuat tekan beton normal sebesar 30,38 MPa. Pada penambahan serbuk eceng gondok dengan kadar 2%, 4%, dan 6% diperoleh kuat tekan masing – masing sebesar 21,99 MPa, 18,16 MPa, dan 14,44 MPa. Penambahan serbuk eceng gondok ternyata mengurangi kuat tekan beton. Semakin tinggi persentase penambahan serbuk eceng gondok, kuat tekan beton semakin kecil. Hasil yang didapatkan dari penelitian ini adalah dibawah kuat tekan beton normal.
PENGENALAN SAPTA PESONA WISATA PADA ANAK USIA DINI DI PAUD KUMARA ASIH MATARAM 2019
Authors: Damayanti Si Luh Putu , Bagiastra I Ketut , Yulendra Lalu
Published: November 2019

Sapta pesona pariwisata  merupakan jabaran konsep sadar wisata yang terkait dengan dukungan  dan peran masyarakat untuk mewujudkan  suasana lingkunga yang kondusif  melalui perwujudan tujuh unsur  dalam sapta pesona yaitu keamanan, ketertiban, kebersihan, kesejukan ,keindahan, keramah tamahan dan kenangan. Kesehatan adalah modal utama untuk kita melangkah dan beraktifitas. Tanpa kesehatan kita akan kesulitan untuk beraktifitas. Banyak orang yang menginginkan kesehatan namun dalam berpola hidupnya tidak di perhatikan.Pengenalan  sapta pesona dapat dilakukan melalui pembiasaan yang dilakukan di sekolah maupun dirumah Penerapan gaya hidup sehat memang seharusnya dilakukan sejak dini. Ini agar kebiasaan dalam menerapkan gaya hidup yang sehat dapat terus dilakukan hingga dewasa. Dengan kebiasaan yang ditanamkan sejak usia anak-anak, tidak akan sulit untuk mempertahankannya saat anak sudah dewasa nanti. Ini penting karena pengenalan sapta pesona pariwista sejak dini akan menjadi fondasi yang kuat bagi perkembangan dunia pariwisata kedepan gaya hidup sehat akan membawa kita pada keadaan tubuh yang sehat. Hal ini disebabkan karena usia anak-anak membutuhkan pendidikan yang sangat mendasar dan sangat menentukan bagi perkembangan anak dikemudian hari,bahkan ada yang berpendapat bahwa usia dini adalah usia emas (golden age ) yang hanya terjadi sekali dalam kehidupan manusia. Metode dan pendekatan yang ada perlu diketahui bahwa kita harus memahami benar metode atau pendekatan yang akan dipakai, karena ini akan berpengaruh terhadap optimal tidaknya keberhasilan pengenalan sapta pesona pariwisata di kalangan anak usia dini .Metode yang digunakan sangatlah bervariasi diantaranya  bercerita , bernyanyi, bersajak dan karya wisata.dan paling penting adalah pembiasan prilaku  hidup sehat dan menjaga kelestarian lingkungan
AN ANALISYS OF STUDENTS’ COMPETENCE IN WRITING DESCRIPTIVE PARAGRAPH: A CASE STUDY AT THE SECOND YEAR STUDENTS OF SMA 1 PUJUT IN ACADEMIC YEAR 2018/2019
Authors: Lume Lume
Published: November 2019

This research aims to know the An Analysis of Students’ competence in writing descriptive paragraph. The subject of this research has been 36 students of class at SMA 1  Pujut in academic year 2018/2019. The research design on one test of SMA 1  Pujut used the one sheet method. In this test the students had to write a descriptive paragraph. The author used the descriptive method for data interpretation. The research revealed a mean score of 53.47 at the test. In detail: the students’ competence in writing descriptive paragraph was fairly good (38.8%), good (13.8%), excellent (5.5%), poor (36.1%) and very poor (5.5%). In general, based on the result, the author concludes that the students’ competence in writing descriptive paragraphs was classified fairly good. It demonstrated that most of the students (80%) of class at SMA 1  Pujut were able to write descriptive paragraph using their own words as good possible.
PENGEMBANGAN WISATA WARISAN BUDAYA SEBAGAI DAYA TARIK KOTA TANGERANG CULTURAL HERITAGE TOURISM DEVELOPMENT AS TOURIST ATTRACTION IN TANGERANG
Authors: Ritonga Roozana Maria
Published: November 2019

Cultural heritage is what humans are living now and what is passed on to future generations and is usually valuable and worthy of being protected and preserved. The application of cultural heritage as a tourist attraction had developed into a tourism inndustry that is very extensive and much in demand today. Cultural heritage tourism is a journey related to the history of the trip is packed with the aim of visiting a place that is considered to have an important history for an area or city that can be a tourist attraction. Tangerang city has the potential to developed cultural heritage tourism because many places are considered as tourism potential that can be a major attraction for tourist visiting to tangerang city.The problem the authors take in this research is about development of cultural heritage tourism into a tourist attraction in the city of tangerang. Tourist attaraction should be able to contribute satisafction for tourists in aspects 4 a (attractions, accessibility, amenities and ancillary or institutional). This research was conducted to determine the potential of existing cultural heritage tourism attractions and make this potential as a tourist attarction in tangerang. The research method used is a qualitative research method. Researchers use exsisting data in the city of government in the development of cultural tourism as well as the results of interviews that have been conducted to the resource persons.The results were analysed using development theory such as attraction, accessibility, amenities and institutional. Aspects of attractions include something to see, learn, taste and experiences which has not been completed offered to tourists, but there are plans to add existing attractions. Aspects of accessibility is suffieciently because of many transportation and easy roads to reach the destination. Aspects of amenities is also adequately for the reason that restaurant and lodgings are not far from the heritage area.the institutional aspects of tangerang city government now has support and plan for heritage in tangerang city to be accomplished and can be enjoyed by society and tourists.Based on the research results concluded that tangerang city can be developed into a tourist attraction from the four aspects. Furthermore, tangerang city must pursue the concept of tourism development towards sustainability and environmentally so the potential heritage tourism is secured and conserved.
MODEL COLLABORATIVE GOVERNANCE DALAM ANALISIS PENGEMBANGAN POTENSI PARIWISATA BERBASIS INDIGENOUS TOURISM
Authors: Rozikin Mochamad , Wismanu Rendra Eko , Muttaqin Andhyka
Published: November 2019

Pengembangan sektor pariwisata telah menjadi prioritas pembangunan ekonomi yang berbasis pada potensi daerah. Potensi daerah dibidang pariwisata yang menjadi perhatian bagi pemerintah saat ini yaitu lebih pada potensi kekayaan alam, kekayaan ragam kuliner, pertumbuhan wisata buatan, penguatan wisata budaya dan kearifan lokal. Potensi wisata unggulan tersebut masih memiliki bentuk lain jenis pariwisata yang dapat dikembangkan. Bentuk dan jenis potensi wisata yang beranekaragam ini dapat dikembangkan dan dikelola dengan baik, melalui kolaborasi atau kerjasama oleh semua pihak atau dengan kata lain melalui Collaborative Governance. Kolaborasi yang dilakukan oleh pemeritah pusat, pemerintah daerah, masyarakat, komunitas, pelaku swasta, pihak akademis, Non Governmental Organization (NGO) dan lain sebagainya, merupakan kekuatan dalam mengembangkan potensi pariwisata yang ada. Pada saat ini banyak negara telah berupaya mengemas pariwisata yang dapat memberikan perbedaan dan daya saing yang kuat terhadap negara-negara lain, yaitu melalui dasar pola pengembangan pada sektor budaya dan kearifan lokal. Pengembangan pariwisata berbasis pada budaya dan kearifan lokal ini dengan kata lain dapat disebut dengan pengembangan pariwisata berbasis Indigenous Tourism. Pengembangan potensi pariwisata daerah yang berbasis pada indgenous tourism merupakan pilihan baik dalam meningkatkan daya saing disisi dimensi nilai pada konsep governance, hal ini yang menjadi dasar mengenai model collaborative governance dalam analisis pengembangan potensi pariwisata berbasis indigenous tourism
KOLABORASI PENGGUNAAN MEDIA KOMPUTER DAN SUPERVISI AKADEMIS KEPALA SEKOLAH DALAM MENINGKATAN KETRAMPILAN GURU MENYUSUN ADMINISTRASI DI SDN 2 BUWUN SEJATI KEC. NARMADA TAHUN PELAJARAN 2017-2018
Authors: Kasimun Kasimun
Published: November 2019

Mengajar bukanlah menyelesaikan satu buku, tetapi membantu siswa mencapai kompetensi. Oleh karena itu, hendaknya guru menggunakan banyak sumber materi. Bagi guru, sumber utama untuk mendapatkan materi pembelajaran adalah buku teks dan buku penunjang yang lain. Namun masalah penting yang sering dihadapi guru dalam kegiatan pembelajaran adalah memilih atau menentukan materi pembelajaran atau bahan ajar yang tepat dalam rangka membantu siswa mencapai kompetensi.Tujuan dari penelitian tindakan sekolah( PTS ) ini adalah untuk mengetahui sejauh mana pembinaan kepala sekolah melalui supervisi akademik untuk meningkatkan kinerja guru dalam memanfaatkan bahan ajar.Dalam penelitian tindakan sekolah( PTS ) ini dilakukan dalam 3 siklus, dari hasil tindakan yang dilakukan terbukti dapat meningkatkan kemampuan guru  dengan mencapai standar ideal. Berdasarkan analisis hasil penelitian dan diskusi dapat disimpulkan sebagai berikut : Bahwa pembinaan melalui Supervisia Akademis Kepala Sekolah memiliki dampak positif dalam meningkatkan ketrampilan guru, hal ini dapat dilihat dari semakin mantapnya pemahaman guru terhadap pembinaan yang disampaikan kepala sekolah ( Ketrampilan menyusun administrasi pembelajaran meningkat dari siklus I, II, dan II ) yaitu masing-masing 42,86  % ; 71,07 % ;98,86 % secara kelompok dikatakan tuntas/meningkat karena sudah mencapai ketuntasan. serta dapat mengorganisasikan sekolah kearah perubahan yang diinginkan telah mencapai  85 % ketercapaiannya, maka kinerja guru dalam menyusun administrasi pembelajaran dengan menerapkan pembinaan melalui supervisi akademis kepala sekolah tersebut dinyatakan efektif dan tuntas
REFLEXÕES DE UMA PESQUISA COLABORATIVA NA FORMAÇÃO CONTINUADA DE PROFESSORES DE MATEMÁTICA A PARTIR DO PROGRAMA OBSERVATÓRIO DA EDUCAÇÃO
Authors: Jorge Nickson Moretti , Pereira Patrícia Sandalo
Published: November 2019

O artigo traz um recorte da dissertação de mestrado intitulada "Reflexões sobre a prática docente de um professor de matemática a partir da pesquisa colaborativa", vinculada ao Programa de Pós-Graduação em Educação Matemática da Universidade Federal de Mato Grosso do Sul (UFMS).Esta pesquisa foi atrelada ao projeto em rede denominado “Trabalho colaborativo com professores que ensinam Matemática na Educação Básica em escolas públicas das regiões Nordeste e Centro-Oeste”, no Programa Observatório da Educação - OBEDUC, financiado pela CAPES. Neste artigo, temos como objetivo apresentar algumas contribuições do Programa Observatório da Educação – OBEDUC para a formação continuada de professores de Matemática a partir dos movimentos propiciados pelapesquisa colaborativa. Como referencial teórico-metodológico, utilizamos a pesquisa colaborativa. Concluímos que, a partir do Programa OBEDUC, o movimento propiciado pela pesquisa colaborativa, por meio da espiral reflexiva ampliada, possibilitou diálogos reflexivos, levando o partícipe amudanças de suas práticas, por meio dos significados e das ressignificações de suas práticas docentes.
PROVA-ESCRITA-EM-FASES DE MATEMÁTICA NO 5º ANO DO ENSINO FUNDAMENTAL
Authors: Prestes Diego Barboza , Buriasco Regina Luzia Corio de
Published: November 2019

Este artigo apresenta uma discussão a respeito da produção escrita de um aluno do 5o ano do Ensino Fundamental, obtida por meio de uma Prova-Escrita-em-Fases. Tal discussão é um recorte de uma dissertação de mestrado, de natureza qualitativa, realizada com uma turma do 5o ano do Ensino Fundamental de uma escola pública da cidade de Apucarana-PR, dentro das ações do Programa Observatório da Educação, em que se utilizou como instrumento de avaliação uma Prova-Escrita-em-Fases. Ao tomar a avaliação da aprendizagem escolar como prática de investigação, foi possível analisar as produções escritas dos alunos em diferentes momentos para realizar intervenções. Assim como na abordagem de ensino da Educação Matemática Realística, os alunos investigadosdesempenharam um papel de protagonistas de suas próprias aprendizagens, e os pesquisadores atuaram como um guia, intervindo no processo por meio de apontamentos escritos na prova no decorrer das fases. A Prova-Escrita-em-Fases mostrou ser um instrumento de avaliação com potencial para possibilitar um diálogo reflexivo entre professor e alunos, além de ser mais uma oportunidade de aprendizagem.
Bioregulators Can Improve Biomass Production, Photosynthetic Efficiency, and Ornamental Quality of Gazania rigens L.
Authors: Zulfiqar Faisal , Younis Adnan , Abideen Zainul , Francini Alessandra , Ferrante Antonio
Published: November 2019

Gazania rigens L. is a perennial herbaceous plant that belongs to the Asteraceae family, widely used as bedding or ornamental potted plants. The environmental and economic sustainability of ornamental production can be enhanced using environmentally friendly bioregulators. A pot experiment was conducted to evaluate the influence of key bioregulators gibberellic acid ((GA3) at 50, 100 or 150 mg L−1), humic acid ((HA) at 100, 300 or 600 mg L−1), and ascorbic acid ((AA) at 50, 100 or 200 mg L−1)), on the growth, leaf gas exchange, and ornamental quality of G. rigens. The results indicated that plants treated with foliar applications of GA3, HA, or AA exhibited higher plant fresh and dry biomass, plant height, leaf area, and leaf area ratio, root-shoot ratio, root-shoot mass fractions, and number of flowers, as well as the flowers display time. All bioregulator treatments enhanced the vegetative and floral characteristics of Gazania plants. The GA3 was the most efficient at the concentration of 100 mg L−1. The highest efficacy of HA and AA treatments was observed at the higher concentrations, 600 and 200 mg L−1, respectively. These results were associated with higher photosynthetic rate (A), transpiration rate (E) as well as stomatal conductance (gs), and water use efficiency (WUE). In conclusion, the results suggest that foliar-applied bioregulators to Gazania are promising and represent sustainable strategies to enhance growth, flowering, and flower display time of Gazania plants.
The Effect of Behaviour and Diet on the Rumen Temperature of Holstein Bulls
Authors: Rutherford Naomi H. , Gordon Alan W. , Lively Francis O. , Arnott Gareth
Published: November 2019

Rumen temperature boluses are becoming increasingly used as a means of monitoring core body temperature for the detection of ill health. However, the effect of behavior on rumen temperature is largely unknown. This research investigates the impact of behaviour and diet on the rumen temperature of Holstein bulls, both at grass, and in a housed environment. Rumen temperature was recorded at five-minute intervals using a bolus. Direct observations were conducted on young bulls in two studies (i) at grass (n = 30) and (ii) while housed (n = 32). In addition, activity monitors were attached to bulls at grass (n = 24). Within each study, diet differed by the level of concentrate supplementation. There was no effect of diet on rumen temperature. Significant differences in rumen temperature were observed between behaviour groups for bulls at grass (p < 0.001) and housed (p < 0.001). Furthermore, drinking resulted in the lowest rumen temperature (grass 35.97 °C; housed 36.70 °C). Therefore, rumen temperature is affected by behavior; however, the temperatures recorded were not outside the normal temperature range for healthy cattle.
IVUS Image Segmentation Using Superpixel-Wise Fuzzy Clustering and Level Set Evolution
Authors: Xia Menghua , Yan Wenjun , Huang Yi , Guo Yi , Zhou Guohui , Wang Yuanyuan
Published: November 2019

Reliable detection of the media-adventitia border (MAB) and the lumen-intima border (LIB) in intravascular ultrasound (IVUS) images remains a challenging task that is of high clinical interest. In this paper, we propose a superpixel-wise fuzzy clustering technique modified by edges, followed by level set evolution (SFCME-LSE), for automatic border extraction in 40 MHz IVUS images. The contributions are three-fold. First, the usage of superpixels suppresses the influence of speckle noise in ultrasound images on the clustering results. Second, we propose a region of interest (ROI) assignment scheme to prevent the segmentation from being distracted by pathological structures and artifacts. Finally, the contour is converged towards the target boundary through LSE with an appropriately improved edge indicator. Quantitative evaluations on two IVUS datasets by the Jaccard measure (JM), the percentage of area difference (PAD), and the Hausdorff distance (HD) demonstrate the effectiveness of the proposed SFCME-LSE method. SFCME-LSE achieves the minimal HD of 1.20 ± 0.66 mm and 1.18 ± 0.70 mm for the MAB and LIB, respectively, among several state-of-the-art methods on a publicly available dataset.
StreamflowVL: A Virtual Fieldwork Laboratory that Supports Traditional Hydraulics Engineering Learning
Authors: Mirauda Domenica , Capece Nicola , Erra Ugo
Published: November 2019

This paper describes an innovative virtual laboratory for students of Hydraulic Engineering at an Italian university that shows water discharge measurement techniques applied in open-channel flows. Such new technology, which supports traditional practical classes, has the potential to increase students’ motivation and improve their skills, as well as simultaneously reducing the costs, time, and possible dangers that continuous field experiments would involve. Thanks to this immersive and interactive experience that is carried out indoors, students learn to move around a fluvial environment, as well as work more safely and with reduced risks of accidents. Besides, the virtual lab can boost learners’ interest by combining education with pleasure and making knowledge more fun. Collaboration with a group of students enrolled in the Master’s degree course of the Civil and Environmental Engineering program at Basilicata University at the early stages of developing the educational tool led to improvements in its performance and features. Also, a preliminary testing procedure carried out on a student sample, verified the achievement of the students’ learning objectives in terms of knowledge and skills. Such analysis indicated that students took more active role in the teaching/learning process and they showed greater interest in the topic dealt with through the new technology compared to the involvement of students observed during traditional lessons in previous years. The architecture and operational modes of the virtual laboratory as well as the results of the preliminary analysis are discussed.
Observing and Modeling the Response of Placentia Bay to an Extratropical Cyclone
Authors: Xu Guangjun , Han Guoqi , Dong Changming , Yang Jingsong , DeYoung Brad
Published: November 2019

An extratropical cyclone reported to have the largest wind speed in Newfoundland in morethan a decade landed on the island of Newfoundland on 11 March 2017. The oceanic responses inPlacentia Bay on the southeast coast of Newfoundland to the winter storm were examined usingobserved data and the Finite-Volume Community Ocean Model (FVCOM). The peak non-tidal waterlevel increase, i.e., storm surge, reached 0.85mat St. Lawrence and 0.77mat Argentia on Placentia Bay.Sea surface temperature slightly decreased after the storm passage according to buoy and satellitemeasurements. Root mean square dierences (RMSD) of the magnitude of storm surge between modelresults and observations are 0.15 m. The model sea surface temperature showed a small decrease,consistent with observations, with RMSDs from 0.19 to 0.64 C at buoy stations. The simulatedsurface current changes agree with buoy observations, with model-observation velocity dierenceratios (VDR) of 0.75–0.88. It was found that, at Argentia (St. Lawrence), the peak storm surge inPlacentia Bay was dominantly (moderately) associated with the inverse barometric eect, and thesubsequent negative surge was mainly due to the wind eect at both stations. The sea surface coolingwas associated with oceanic heat loss. In the momentum balance, the Coriolis, pressure gradient,and advection terms were all important during the storm, while the first two terms were predominantbefore and after the storm.
Evaluation of New CORDEX Simulations Using an Updated Köppen–Trewartha Climate Classification
Authors: Remedio Armelle Reca , Teichmann Claas , Buntemeyer Lars , Sieck Kevin , Weber Torsten , Rechid Diana , Hoffmann Peter , Nam Christine , Kotova Lola , Jacob Daniela
Published: November 2019

A new ensemble of climate and climate change simulations covering all major inhabited regions with a spatial resolution of about 25 km, from the WCRP CORDEX COmmon Regional Experiment (CORE) Framework, has been established in support of the growing demands for climate services. The main objective of this study is to assess the quality of the simulated climate and its fitness for climate change projections by REMO (REMO2015), a regional climate model of Climate Service Center Germany (GERICS) and one of the RCMs used in the CORDEX-CORE Framework. The CORDEX-CORE REMO2015 simulations were driven by the ECMWF ERA-Interim reanalysis and the simulations were evaluated in terms of biases and skill scores over ten CORDEX Domains against the Climatic Research Unit (CRU) TS version 4.02, from 1981 to 2010, according to the regions defined by the Köppen–Trewartha (K–T) Climate Classification types. The REMO simulations have a relatively low mean annual temperature bias (about ± 0.5 K) with low spatial standard deviation (about ± 1.5 K) in the European, African, North and Central American, and Southeast Asian domains. The relative mean annual precipitation biases of REMO are below ± 50 % in most domains; however, spatial standard deviation varies from ± 30 % to ± 200 %. The REMO results simulated most climate types relatively well with lowest biases and highest skill score found in the boreal, temperate, and subtropical regions. In dry and polar regions, the REMO results simulated a relatively high annual biases of precipitation and temperature and low skill. Biases were traced to: missing or misrepresented processes, observational uncertainty, and uncertainties due to input boundary forcing.
Transient Chemogenetic Inhibition of D1-MSNs in the Dorsal Striatum Enhances Methamphetamine Self-Administration
Authors: Oliver Robert J. , Purohit Dvijen C. , Kharidia Khush M. , Mandyam Chitra D.
Published: November 2019

The dorsal striatum is important for the development of drug addiction; however, the role of dopamine D1 receptor (D1R) expressing medium-sized spiny striatonigral (direct pathway) neurons (D1-MSNs) in regulating excessive methamphetamine intake remains elusive. Here we seek to determine if modulating D1-MSNs in the dorsal striatum alters methamphetamine self-administration in animals that have demonstrated escalation of self-administration. A viral vector-mediated approach was used to induce expression of the inhibitory (Gi coupled-hM4D) or stimulatory (Gs coupled-rM3D) designer receptors exclusively activated by designer drugs (DREADDs) engineered to specifically respond to the exogenous ligand clozapine-N-oxide (CNO) selectively in D1-MSNs in the dorsal striatum. CNO in animals expressing hM4D increased responding for methamphetamine compared to vehicle in a within subject treatment paradigm. CNO in animals that did not express DREADDs (DREADD naïve-CNO) or expressed rM3D did not alter responding for methamphetamine, demonstrating specificity for hM4D-CNO interaction in increasing self-administration. Postmortem tissue analysis reveals that hM4D-CNO animals had reduced Fos immunoreactivity in the dorsal striatum compared to rM3D-CNO animals and DREADD naïve-CNO animals. Cellular mechanisms in the dorsal striatum in hM4D-CNO animals reveal enhanced expression of D1R and Ca2+/calmodulin-dependent kinase II (CaMKII). Conversely, rM3D-CNO animals had enhanced activity of extracellular signal-regulated kinase (Erk1/2) and Akt in the dorsal striatum, supporting rM3D-CNO interaction in these animals compared with drug naïve controls, DREADD naïve-CNO and hM4D-CNO animals. Our studies indicate that transient inhibition of D1-MSNs-mediated strengthening of methamphetamine addiction-like behavior is associated with cellular adaptations that support dysfunctional dopamine signaling in the dorsal striatum.
Reactivation of Hepatitis B Virus in Patients with Multiple Myeloma
Authors: Tsukune Yutaka , Sasaki Makoto , Komatsu Norio
Published: November 2019

Reactivation of hepatitis B virus (HBV) is a well-known complication in patients with hematological malignancies during or after cytotoxic chemotherapy. If the initiation of antiviral therapy is delayed in patients with HBV reactivation, these patients can develop severe hepatitis and may die of fulminant hepatitis. The preventive strategy for HBV reactivation in patients with malignant lymphoma has already been established based on some prospective studies. As there was an increased number of novel agents being approved for the treatment of multiple myeloma (MM), the number of reported cases of HBV reactivation among MM patients has gradually increased. We conducted a Japanese nationwide retrospective study and revealed that HBV reactivation in MM patients is not rare and that autologous stem cell transplantation is a significant risk factor. In this study, around 20% of all patients with HBV reactivation developed HBV reactivation after 2 years from the initiation of therapy, unlike malignant lymphoma. This might be due to the fact that almost all of the patients received chemotherapy for a long duration. Therefore, a new strategy for the prevention of HBV reactivation in MM patients is required.
Endometrial Cancer Stem Cells: Role, Characterization and Therapeutic Implications
Authors: Giannone Gaia , Attademo Laura , Scotto Giulia , Genta Sofia , Ghisoni Eleonora , Tuninetti Valentina , Aglietta Massimo , Pignata Sandro , Valabrega Giorgio
Published: November 2019

Endometrial cancer (EC) is the most frequent gynecological cancer. In patients with relapsed and advanced disease, prognosis is still dismal and development of resistance is common. In this context, endometrial Cancer Stem Cells (eCSC), stem-like cells capable to self-renewal and differentiation in mature cancer cells, represent a potential field of expansion for drug development. The aim of this review is to characterize the role of eCSC in EC, their features and how they could be targeted. CSC are involved in progression, invasiveness and metastasis (though epithelial to mesenchimal transition, EMT), as well as chemoresistance in EC. Nevertheless, isolation of eCSC is still controversial. Indeed, CD133, Aldheyde dehydrogenase (ALDH), CD117, CD55 and CD44 are enriched in CSCs but there is no universal marker nowadays. The most frequently activated pathways in eCSC are Wingless-INT (Wnt)/β-catenin, Notch1, and Hedghog, with a high expression of self-renewal transcription factors like Octamer binding transcription factor 4 (OCT), B Lymphoma Mo-MLV Insertion Region 1 Homolog (BMI1), North American Network Operations Group Homebox protein (NANOG), and SRY-Box 2 (SOX2). These pathways have been targeted with selective drugs alone or in combination with chemotherapy and immunotherapy. Unfortunately, although preclinical results are encouraging, few clinical data are available.
Optimal Coordination of Wind Power and Pumped Hydro Energy Storage
Authors: Al-Masri Hussein M. K. , Al-Quraan Ayman , AbuElrub Ahmad , Ehsani Mehrdad
Published: November 2019

A study combining wind power with pumped hydro energy storage for the Jordanian utility grid is presented. Three solvers of the Matlab optimization toolbox are used to find the optimal solution for the cost of energy in a combined on-grid system. Genetic algorithm, simulated annealing (SA), and pattern search (PS) solvers are used to find the optimal solution. The GA solution of 0.0955388 $/kWh is economically feasible. This is 28.7% lower than the electricity purchased from the conventional utility grid. The discounted payback period to recover the total cost is 10.271 years. The suggested configuration is shown to be feasible by comparing it to real measurements for this case and a previous wind-only case. It is shown that the indicators of the optimal solution are improved. For instance, carbon dioxide emissions (ECO2) and conventional grid energy purchases are reduced by 24.69% and 24.68%, respectively. Moreover, it is shown that the benefits of adding hydro storage, combined with increasing the number of wind turbine units, reduces the cost of energy of renewables (COERenewables). Therefore, combining hydro storage with wind power is economically, environmentally, and technically a more efficient alternative to the conventional power generation.
Looking for Energy Losses of a Rotary Permanent Magnet Magnetic Refrigerator to Optimize Its Performances
Authors: Maiorino Angelo , Mauro Antongiulio , Del Duca Manuel Gesù , Mota-Babiloni Adrián , Aprea Ciro
Published: November 2019

In this paper, an extensive study on the energy losses of a magnetic refrigerator prototype developed at University of Salerno, named ‘8MAG’, is carried out with the aim to improve the performance of such a system. The design details of ‘8MAG’ evidences both mechanical and thermal losses, which are mainly attributed to the eddy currents generation into the support of the regenerators (magnetocaloric wheel) and the parasitic heat load of the rotary valve. The latter component is fundamental since it imparts the direction of the heat transfer fluid distribution through the regenerators and it serves as a drive shaft for the magnetic assembly. The energy losses concerning eddy currents and parasitic heat load are evaluated by two uncoupled models, which are validated by experimental data obtained with different operating conditions. Then, the achievable coefficient of performance (COP) improvements of ‘8MAG’ are estimated, showing that reducing eddy currents generation (by changing the material of the magnetocaloric wheel) and the parasitic heat load (enhancing the insulation of the rotary valve) can lead to increase the COP from 2.5 to 2.8 (+12.0%) and 3.0 (+20%), respectively, and to 3.3 (+32%), combining both improvements, with an hot source temperature of 22 °C and 2 K of temperature span.
Lead-Acid Battery Sizing for a DC Auxiliary System in a Substation by the Optimization Method
Authors: Ribič Janez , Pihler Jože , Maruša Robert , Kokalj Filip , Kitak Peter
Published: November 2019

Lead-acid batteries are the most frequently used energy storage facilities for the provision of a backup supply of DC auxiliary systems in substations and power plants due to their long service life and high reliability. It is possible to define the load in these systems, therefore the IEEE 485 Standard can be used for the selection of batteries according to the conventional method of selection. Special attention is paid in the paper to the technical selection of a lead-acid battery, which depends on its operational reliability that decreases with battery aging. It is defined by the extent of maintenance during its service life. A cost analysis was also carried out, which took into consideration maintenance and procurement costs, as well as the costs of the related air conditioning that keeps the prescribed temperature and ventilates the battery room. The impact is shown of selecting a lead-acid battery on the battery room’s operating safety when charging. The final selection of lead-acid battery is performed using an optimization algorithm of differential evolution. Using the optimization process, the new battery selection method includes the technical sizing criteria of the lead-acid battery, reliability of operation with maintenance, operational safety, and cost analysis. Two cases of selection of lead-acid batteries for the backup supply of a DC auxiliary system in a transmission substation are presented in the paper, where the input data were determined based on measurements in an existing substation. A comparison is made between the existing conventional and new lead-acid battery selection method based on optimization.
A Regularized Raking Estimator for Small-Area Mapping from Forest Inventory Surveys
Authors: Nagle Nicholas N. , Schroeder Todd A. , Rose Brooke
Published: November 2019

In this paper, we propose a new estimator for creating expansion factors for survey plots in the US Forest Service (USFS) Forest Inventory and Analysis program. This estimator was previously used in the GIS literature, where it was called Penalized Maximum Entropy Dasymetric Modeling. We show here that the method is a regularized version of the raking estimator widely used in sample surveys. The regularized raking method differs from other predictive modeling methods for integrating survey and ancillary data, in that it produces a single set of expansion factors that can have a general purpose which can be used to produce small-area estimates and wall-to-wall maps of any plot characteristic. This method also differs from other more widely used survey techniques, such as GREG estimation, in that it is guaranteed to produce positive expansion factors. Here, we extend the previous method to include cross-validation, and provide a comparison to expansion factors between the regularized raking and ridge GREG survey calibration.
Pedestrian Attribute Recognition with Graph Convolutional Network in Surveillance Scenarios
Authors: Song Xiangpeng , Yang Hongbin , Zhou Congcong
Published: November 2019

Pedestrian attribute recognition is to predict a set of attribute labels of the pedestrian from surveillance scenarios, which is a very challenging task for computer vision due to poor image quality, continual appearance variations, as well as diverse spatial distribution of imbalanced attributes. It is desirable to model the label dependencies between different attributes to improve the recognition performance as each pedestrian normally possesses many attributes. In this paper, we treat pedestrian attribute recognition as multi-label classification and propose a novel model based on the graph convolutional network (GCN). The model is mainly divided into two parts, we first use convolutional neural network (CNN) to extract pedestrian feature, which is a normal operation processing image in deep learning, then we transfer attribute labels to word embedding and construct a correlation matrix between labels to help GCN propagate information between nodes. This paper applies the object classifiers learned by GCN to the image representation extracted by CNN to enable the model to have the ability to be end-to-end trainable. Experiments on pedestrian attribute recognition dataset show that the approach obviously outperforms other existing state-of-the-art methods.
Authentication of the Geographical Origin of Margarines and Fat-Spread Products from Liquid Chromatographic UV-Absorption Fingerprints and Chemometrics
Authors: Bikrani Sanae , Jiménez-Carvelo Ana M. , Nechar Mounir , Bagur-González M. Gracia , Souhail Badredine , Cuadros-Rodríguez Luis
Published: November 2019

Fat-spread products are a stabilized emulsion of water and vegetable oils. The whole fat content can vary from 10 to 90% (w/w). There are different kinds, which are differently named, and their composition depends on the country in which they are produced or marketed. Thus, having analytical solutions to determine geographical origin is required. In this study, some multivariate classification methods are developed and optimised to differentiate fat-spread-related products from different geographical origins (Spain and Morocco), using as an analytical informative signal the instrumental fingerprints, acquired by liquid chromatography coupled with a diode array detector (HPLC-DAD) in both normal and reverse phase modes. No sample treatment was applied, and, prior to chromatographic analysis, only the samples were dissolved in n‑hexane. Soft independent modelling of class analogy (SIMCA) and partial least squares-discriminant analysis (PLS-DA) were used as classification methods. In addition, several classification strategies were applied, and performance of the classifications was evaluated applying proper classification metrics. Finally, 100% of samples were correctly classified applying PLS-DA with data collected in reverse phase.
Effects of Soaking and Fermentation Time on Biogenic Amines Content of Maesil (Prunus Mume) Extract
Authors: Yoon So Hee , Koh Eunmi , Choi Bogyoung , Moon BoKyung
Published: November 2019

Maesil extract, a fruit-juice concentrate derived from Prunus mume prepared by fermenting with sugar, is widely used with increasing popularity in Korea. Biogenic amines in maesil extract were extracted with 0.4 M perchloric acid, derivatized with dansyl chloride, and detected using high-performance liquid chromatography. Among 18 home-made maesil extracts collected from different regions, total biogenic amine content varied from 2.53 to 241.73 mg/L. To elucidate the effects of soaking and fermentation time on biogenic amine content in maesil extract, maesil was soaked in brown sugar for 90 days and the liquid obtained was further fermented for 180 days at 15 and 25 °C, respectively. The main biogenic amines extracted were putrescine and spermidine and the total biogenic amine content was higher at 25 °C than at 15 °C. Soaking at 15 and 25 °C increased the total biogenic amines content from 14.14 to 34.98 mg/L and 37.33 to 69.05 mg/L, respectively, whereas a 180 day fermentation decreased the content from 31.66 to 13.59 mg/L and 116.82 to 57.05 mg/L, respectively. Biogenic amine content was correlated with total amino acid content (particularly, arginine content). Based on these results, we have considered that biogenic amine synthesis can be reduced during maesil extract production by controlling temperature and fermentation time.
Coding and Non-Coding RNA Abnormalities in Bipolar Disorder
Authors: Luykx Jurjen J. , Giuliani Fabrizio , Giuliani Giuliano , Veldink Jan
Published: November 2019

The molecular mechanisms underlying bipolar disorder (BPD) have remained largely unknown. Postmortem brain tissue studies comparing BPD patients with healthy controls have produced a heterogeneous array of potentially implicated protein-coding RNAs. We hypothesized that dysregulation of not only coding, but multiple classes of RNA (coding RNA, long non-coding (lnc) RNA, circular (circ) RNA, and/or alternative splicing) underlie the pathogenesis of BPD. Using non-polyadenylated libraries we performed RNA sequencing in postmortem human medial frontal gyrus tissue from BPD patients and healthy controls. Twenty genes, some of which not previously implicated in BPD, were differentially expressed (DE). PCR validation and replication confirmed the implication of these DE genes. Functional in silico analyses identified enrichment of angiogenesis, vascular system development and histone H3-K4 demethylation. In addition, ten lncRNA transcripts were differentially expressed. Furthermore, an overall increased number of alternative splicing events in BPD was detected, as well as an increase in the number of genes carrying alternative splicing events. Finally, a large reservoir of circRNAs populating brain tissue not affected by BPD is described, while in BPD altered levels of two circular transcripts, cNEBL and cEPHA3, are reported. cEPHA3, hitherto unlinked to BPD, is implicated in developmental processes in the central nervous system. Although we did not perform replication analyses of non-coding RNA findings, our findings hint that RNA dysregulation in BPD is not limited to coding regions, opening avenues for future pharmacological investigations and biomarker research.
Strengthening Routine Immunization Services in an Angolan Comuna: The Fight against the Burden of Unvaccinated Children in the Sustainable Development Goals Era
Authors: Fattorini Mattia , Wilunda Calistus , Raguzzoni Gloria , Quercioli Cecilia , Messina Gabriele , Fantini Maria Pia , Putoto Giovanni
Published: November 2019

In May 2018, the non-governmental organization (NGO) Doctors with Africa CUAMM began to implement an intervention to strengthen Chiulo Hospital’s public health section to deliver immunization services in Mucope Comuna, Ombadja District. We aimed to evaluate the effect of this intervention. During the intervention period, actions such as staff training, improvement in the monitoring of vaccine stockpile, and the involvement of Community Health Workers were performed. The effects of the intervention on the number of vaccine doses administered were examined using negative binomial regression. Doses administered were 14,221 during the intervention period and 11,276 in the pre-intervention one. The number of administered doses was 26% higher (95% CI 9%–45%) in the intervention period than in the pre-intervention period. This was driven by vaccine doses administered during outreach sessions, where a statistically significant increase of 62% (95% CI 28%–107%) was observed. Regarding individual vaccines, statistically significant increases in the number of doses were observed for OPV2 (76%), OPV3 (100%), Penta3 (53%), PCV3 (53%), and Rota2 (43%). The NGO interventions led to improved delivery of immunization services in the study area. Greater increases were observed for vaccine doses that are more likely to be missed by children.