bluuebunny/crossref_metadata_2025 huggingface dataset:
A Comprehensive Review of The Impact of Quench Nozzles on Pressure Vessel Design
Authors: Sandeep Sakharam Patil  , Nitish Kumar Gautam  , R.J. Patil
Published: November 2023

This research examines the influence of cooling spout positioning on pressure container blueprints, particularly emphasizing strain features. Sprayers are crucial for ingress and egress objectives in force containers, and although maximum positioning upholds container uniformity, operation necessities occasionally necessitate circumferential positioning, resulting in uniformity disturbance. The Finite Element Method (FEM) is employed to examine the distribution of strain, while pressure container prototypes fluctuate in the number of spouts and inclinations. By means of an all-inclusive examination, it was discovered that the strain measurements for every circumstance were under the security limit of 50 megapascals. Remarkably, the arrangement with four spouts at 90-degree intervals displayed negligible distortion and sustained strain levels within satisfactory boundaries, imparting valuable perceptions for enhancing the pressure container blueprint with cooling spouts on the circumference, guaranteeing structural soundness and security.
Agro-Morphological Exploitation of Genetic Diversity and Multivariate Analysis of Indigenous Chickpea (Cicer Arietinum L.) Germplasm
Authors: Dattesh Tamatam  , Manoj Kumar Pandey  , Bijendra Kumar
Published: November 2023

For most of the examined variables, there was significant variation between the germplasm lines. Independent of their breeding locations, the genotypes under study were grouped into seven clusters by genetic diversity analysis. Cluster I contained the most genotypes, 24 and the fewest in clusters V and VII, which were solitary. In contrast, cluster II held 10 genotypes, cluster III had 7, and clusters IV and VI could each hold 4 genotypes. Clusters III and VI had the greatest inter-cluster distance, which indicated that their genotypes had the greatest genetic diversity. According to principal component analysis (PCA), Four of the first fourteen PCs had eigenvalues greater than one. PC 1 alone accounted for the highest variance of 33.1%, followed by PC 2 with 21.7%. The outcomes of this investigation might be used as a foundation for defining and implementing subsequent chickpea breeding initiatives. Seed Yield, Number of Secondary Branches, Harvest Index, and biological yield, test weight, number of seeds per pod, and number of filled pods per plant were all found to be variable in biplot.
Pharmacological Evaluation of Anti-Diabetic Activity of Myricetin in Different Cell Lines
Authors: Narkhede Mahesh Bhanudas , Adhao Vaibhav Suresh
Published: November 2023

The aim of this research work was to perform pharmacological evaluation of Myricetin by using different cell lines. To check the short-term cytotoxic effect of Myricetin in HepG2 and L6 cells, a colorimetric based MTT assay was performed also the glucose utilization in both HepG2 and L6 cells was estimated in order to measure the in vitro anti-diabetic activity of Myricetin. For Lipid accumulation T3-L1 preadipocytes cells are used. For measurement of nitric oxide (NO) the RAW-264.7 cells are used. The alpha-amylase assay and alpha-glucosidase inhibition assay was performed to check if our drug is having effect in term of inhibiting α-amylase and α-glucosidase respectively. Western blot analysis was performed to check the expressions of iNOS protein in LPS treated RAW 264.7 cells before and after the exposure of Myricetin. The cytotoxicity data suggested that Myricetin displayed low level of cytotoxicity in HepG2 cells and in L6 myoblast cell lines. For glucose utilization experiment, it discovered that glucose uptake level was notably increase in HepG2 cells and in L6 myoblast cell lines with the increasing concentration of Myricetin. Myricetin increase lipid accumulation in 3T3-L1 preadipocytes and also inhibits nitric oxide production in RAW 264.7 cell lines. Research was found that Myricetin had no significant effect in order to alter the expression of alpha-amylase and alpha-glucosidase. Our research concludes that Myricetin can be used as a potent anti-diabetic agent.
Purification, Characterization and Antimicrobial Properties of Hemolymph Lectin from the Larva of Red Palm Weevil, Rhynchophorus ferrugineus
Authors: PT Arokya Glory , MR Basil Rose , C Josephine Priyatharshini , C Anitha , X Venci Candida
Published: November 2023

Lectins are renowned hemagglutinins and multivalent proteins with a well-known quality for sugar-binding specificity that participate significantly in invertebrate defense functions. Studies on biological activity of lectin from coleopteran insect are very scarce. A lectin with specific affinity for N-acetyl neuraminic acid was purified from the hemolymph of the larva of the red palm weevil, Rhynchophorus ferrugineus by biospecific adsorption using formalinized rabbit erythrocytes and affinity chromatography using PSM-linked cyanogen bromide activated Sepharose 4B. The specific activity of the lectin purified by affinity chromatography was much higher than the lectin purified by biospecific adsorption. The binding specificity of the weevil lectin distinguishes it from other known insect lectins. Like the crude agglutinin, the lectin purified by affinity chromatography also showed the same pattern of specificity towards erythrocytes. However, 4-to-8-fold decrease in HA titer was observed when tested with the purified lectin. In the same way, reduction is also observed in the HAI titer of the purified lectin with most of the inhibitors except PSM where the HAI titer was identical both in the crude agglutinin and purified lectin. Sugars N-acetyl neuraminic acid, N-acetyl mannosamine and N-acetyl-D-galactosamine inhibited the HA titer of the purified lectin with greater efficacy than the crude agglutinin. The sialic acid specificity of the lectin was confirmed by 16-fold reduction in HA titer with asialo rabbit erythrocytes and 32-fold reduction in HAI titer with desialylated PSM. The purified lectin is homogenous on sodium dodecyl sulphate-polyacrylamide electrophorogram with a molecular weight of about 60 kDa. The lectin showed antimicrobial activity against pathogenic bacteria Streptococcus mutans, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeroginosa and fungi Candida albicans and Aspergillus niger.
Using Gut Microbiome as A Tool in Dietary Intervention for Prevention and Management of Obesity
Authors: Tamilvanan Janani , Kalpana Chinnappan. A.
Published: November 2023

The gut microbiome has trillions of bacteria which play an important role in human health and disease. Several animal and human studies have shown that dysbiosis, microbial imbalance as the causative factor in obesity and metabolic syndrome. Significant research evidence demonstrates that changes in the proportion of Bacteroidetes and Firmicutes has been associated with obesity, but this has been recently challenged. Similar studies were carried out in several populations, however, there are no such studies, to date, among Asian Indians. We aimed to examine the usefulness of gut microbiome testing in developing personalized diet for managing obesity. In this study, we selected individuals, generally healthy, free- living adults, both men and women with BMI 25- 40 kg/m2 and with previous history of failures at weight loss who visited a Weight Loss Clinic, based in Coimbatore, India & were offered a gut microbiome test. We included 54 individuals in the intervention group who received personalized dietary advice for weight loss based on the gut microbiome test and another set of 52 individuals visiting the same clinic were included in the comparison group based on their age, height, weight and BMI who received generic diet. A statistically significant increase in the Bacteroidetes genus was observed in the personalized nutrition group (p = .04). The change (delta) values in gut microbiome composition in personalized nutrition group were significantly higher at the end of 120 days. Gut microbiome-based personalized microbiome modulation through diet significantly improves gut microbiome profiles among obese individuals.  We would further need studies with larger sample size to validate these study findings and long-term follow-up are needed.
Lipid-Based Nano-Formulation Development to Enhance Oral Bioavailability of Weakly Aqueous-Soluble Drug for Obesity and Hypertension
Authors: Akhtar Naseem , Ullah Zabih , Khan Mohd Faiyaz , Jain Vicky , Bijani Sabera , Choudhary Ranjay Kumar , Ahmad Nabeel , Rizvi Moattar Raza , Iqbal Danish
Published: November 2023

The most practical method of drug delivery is oral administration because it has a high rate of patient compliance. However, there are significant obstacles to effective oral medication delivery, including low drug enzymatic/metabolic stability and poor water solubility. Especially in the development of drug formulations for the treatment of obesity and hypertension. This research article aims to formulate solid lipid nanoparticles (SLN) of Fucoxanthin and Ramipril by the emulsification and ultrasonication methods. The nanoparticles size, polydispersity index, and the zeta potential, among other parameters, were computed. In addition, FT-IR analysis of compatibility tests between the SLNs and the loaded drug and in vitro drug release experiments were carried out. Lipid-based nano preparations have drawn plenty of interest as efficient vehicles to increase the oral bioavailability of these kinds of medications. We observed that lipid nanoparticles, have enhanced the oral bioavailability of poorly water-soluble drugs used for obesity and hypertension. Provided the above information, formulated SLNs should be further investigated using cutting-edge scientific methodologies to improve its bioavailability.
On the goals of administrative reform as factors in the formation of methods of administrative and legal regulation
Authors: Glazunova I. V.
Published: November 2023

The relevance of the article is due to the importance of the right choice of forms and methods of legal regulation to achieve the goals of administrative reform of public administration. On the basis of the study, the connection (influence) of the goals and objectives of the Russian administrative reform in the 2000s is shown. with the applied administrative and legal methods to achieve them.A number of normative legal acts are considered, which form the basis for the application of modern forms and methods of administrative regulation to solve these problems. It is concluded that a new stage of administrative reform is currently underway, due to constitutional novels.Suggested directions for scientific research in order to further reform Russian public law institutions.
Exploring uterine fibroids and its treatment in current scenario
Authors: Yadav Rajni , Drammeh Isotou , Sahu Mahendra Kumar
Published: November 2023

Uterine Fibroids (leiomyoma) are made of muscle cells and other grow tissues grow in and around of the wall of the uterus. Uterine fibroids benign tumors in women reproduction age worldwide. Many are discovered incidentally on clinically examination. Approximately 30% of women with uterine fibroids will present with severe symptoms, which can include abdominal uterine bleeding, anemia, pelvic pain and constipation. Infertility and recurrent miscarriage may also be symptoms of fibroids, depending on their location and size, especially for sub mucous and intramural myelomas distorting the uterine cavity. Current option for symptomatic fibroid treatment includes expectant medical and surgical management radiology procedures. Ultrasound can be done, when a patient is symptomatic of uterine fibroids. Fibroids are generally classified by their location; intramural fibroids, subserosal fibroids, submucosal fibroids. The cause of uterine fibroids is unknown, But research and clinical experience proposes that genetics, hormonal imbalance, other growth factor and extracellular matrix accumulation could be the contributing factors .Although uterine fibroids are usually not dangerous, they can cause discomfort and lead to complication such as, drop in red blood cell (anemia) which causes fatigue from heavy bleeding. Our aim is to highlight the new treatments and advancements in treating uterine fibroids. Later we have also highlighted the future advancements and innovations that are used in developed countries for same.
Review on optic atrophy
Authors: Saranya A , Kameshwaran  , Shameem S , Sathish KP , Shanmugapriya K , Shabariraj SM
Published: November 2023

The illness known as otic atrophy damages the eye. It causes anterior ischemic optic neuropathy, also known as gloaucoma, and strokes of the optic nerve. A change in vision, notably blurred vision, problems with peripheral (side) vision, problems with colour vision, and a loss of vision sharpness, are indications of optic atrophy. The final stage of a disease process that affects the retinogeniculate section of the visual pathway is called optic atrophy, and it is identified by the non-specific symptom of optic disc pallor. As a result, rather than acting like a real peripheral nerve, the optic nerve, with its 1.2 million fibres, functions more like a white matter tract. Pial capillaries that supply the optic nerve head experience degeneration, which contributes to the pallor of the optic disc seen in optic atrophy.
Clinical Characteristics and Glycaemic Control in Adults Living with Type 1 Diabetes: A 1-Year Retrospective Chart Review at Two South African Public Sector Tertiary Hospitals
Authors: Poobalan Naidoo , Bruno Pauly , Ebrahim Variava , Somasundram Pillay , Zaheer Bayat , Reyna Daya , Michelle Carrihill , Kiolan Naidoo , Lauren Sekhuthe , Sindeep Bhana
Published: November 2023

Background: An estimated 11.8% of the South African population are living with diabetes. There is a paucity of data related to the clinical characteristics and glycaemic control in people living with T1DM within the South African public healthcare sector.

Objective: To describe the clinical characteristics and glycaemic control of people living with T1DM in a public health care setting.

Methods: The study was an observational study conducted at two tertiary public sector hospitals in South Africa by means of a chart review. The study involved adults living with T1DM treated with human insulin for 12 months prior to the date of informed consent.

Results: A total of 224 patients with T1DM were enrolled, with 190 (84.8%) from Chris Hani Baragwanath Academic Hospital and 34 (15.2%) from Klerksdorp Tshepong Hospital Complex. One patient withdrew consent, leaving a total analysed population of 223. Of the 223 patients, 37 (16.6%) were controlled (most recent glycosylated haemoglobin (HbA1c) < 7%) while the remainder 186 (83.4%) were uncontrolled (most recent HbA1c ≥ 7%). The mean age of the study group was 33 ± 9 years. The majority of participants were female (122 [54.7%]) and of black ethnicity (215 [96.4%]). The mean number of hypoglycaemic events per patient-year was 151.4 (SD ± 213.9). Diabetic ketoacidosis occurred more frequently in the uncontrolled group.

Conclusion: The majority of patients in this study did not achieve target HbA1c, placing them at higher risk for long-term diabetes complications. Poor glycaemic control, leading to long term complications, as well as hypoglycaemia and diabetic ketoacidosis adds further strain to the resource constrained public healthcare in South Africa.
Comparison of Chronic Rheumatic Mitral Regurgitation Severity between Cardiac Magnetic Resonance Imaging and Echocardiography
Authors: Meel Ruchika , Peters Ferande , Libhaber Elena , Nethononda Richard
Published: November 2023

Background and Purpose

Traditionally, echocardiography has been used for assessing mitral regurgitation (MR) severity. However, existing qualitative, semi-quantitative and quantitative parameters suffer from several limitations. The shortcomings of the current echocardiographic methods for MR severity assessment are especially pronounced in the context of eccentric MR jets. Cardiac magnetic resonance (CMR) imaging is useful for assessing valvular lesions as it is now the gold standard for assessing left ventricular and left atrial volumes. Therefore, we sought to study and compare echocardiography with CMR for assessment of chronic rheumatic MR severity.

Methods

Twenty-two patients with chronic rheumatic MR who underwent both CMR and echocardiography were studied. For the echocardiography part of the study, the MR severity was assessed as per current guidelines. The CMR measurements were performed per standard guidelines by a single operator experienced in this technique.

Results

The mean age of the study population was 36.3±13.9 years and 81% were females. There was overall poor agreement for the assessment of MR severity using the quantitative parameters for MR assessment between echocardiography and CMR. Although the measurements for end diastolic volume index (EDVi), end systolic volume index (ESVi), regurgitant volume (RV) and regurgitant fraction (RF) showed moderate correlation, these parameters displayed poor agreement between the two tests. We noted discrepant findings in terms of classification of valve lesion severity in seven patients. Six patients were reclassified after CMR to severe MR and one to moderate MR based on quantitative parameters of regurgitant volume (RV) and regurgitant fraction (RF).

Conclusion

In patients with severe chronic rheumatic MR with eccentric jets, when MR quantification by echocardiography is inadequate, CMR derived quantitative volumetric parameters may be useful for accurate classification of the severity of mitral regurgitation.
РАЗВИТИЕ РЕГИОНАЛЬНЫХ ВУЗОВ РОССИЙСКОЙ ФЕДЕРАЦИИ: ВЛИЯНИЕ НА ОБЪЁМЫ ОБРАЗОВАТЕЛЬНОЙ ИММИГРАЦИИ
Authors: Лебедева Тамара Васильевна
Published: November 2023

Актуальность: анализ научных работ в области международной образовательной миграции показывает, что большинство зарубежных и отечественных исследований проведено на страновом уровне и посвящено характеристике объёмов экспорта национальных образовательных услуг, изменению государственной политики в области привлечения на обучение иностранных граждан, особенностям адаптации иностранных студентов и интеграции выпускников на национальном рынке труда. При этом в меньшей степени исследуется влияние международной образовательной иммиграции на процессы, происходящие на отдельных территориях государств – в регионах, районах, городах, в которых привлечение иностранных граждан на обучение в расположенные там вузы рассматривалось бы в качестве приоритета развития и конкурентного преимущества не только конкретного высшего учебного заведения, но и территориального образования в целом. Поэтому определение особенностей современного развития вузов российских регионов, изменение объёмов и распределение образовательных мигрантов являются важным и актуальным направлением научных исследований. Цель: выявление особенностей развития региональных вузов и влияния происходящих в них изменений на объёмы образовательной иммиграции. Методы: статистический анализ, сравнение, обобщение, контент-анализ документов, структурный метод изложения материала. Результаты: в статье проанализированы основные нормативно-правовые документы реформирования системы высшего образования в российских регионах, отмечены особенности и результаты выполнения проектов и программ повышения эффективности деятельности региональных вузов. Особое внимание уделено характеристике объёмов и направлений образовательной иммиграции в вузах российских регионов. Выводы: развитию и укреплению системы высших учебных заведений российских регионов способствовали формирование федеральных вузов, национальных исследовательских университетов, создание сети опорных региональных университетов. Позитивные изменения, произошедшие в вузовских системах регионов страны, привели к увеличению контингента иностранных студентов
Gıda Takviyesi Olarak Astaksantin ve Sağlık Üzerine Etkileri
Authors: IŞIK Funda , İMRE Kadriye Elif
Published: November 2023

Bu çalışma son 25 yılda özellikle son 5 yılda PubMed ve Web of Science veri tabanlarında "astaksantin", "sağlık etkisi" ve "diyet takviyeleri" anahtar kelimeleriyle taranan makaleler aracılığıyla astaksantin kaynakları, üretimi, gıda endüstrisindeki kullanımı ve sağlık üzerindeki potansiyel etkilerini incelemeyi amaçlamaktadır. Astaksantin üzerine yapılan bu kapsamlı derleme, bu doğal antioksidanın biyolojik etkilerini ve insan sağlığına olan potansiyel faydalarını ele almaktadır. Çalışma, astaksantinin oksidatif stres, inflamasyon, bağırsak mikrobiyotası, nörolojik hastalıklar, terapötik kullanımları ve yaşlanma karşıtı stratejilerdeki rolünü çeşitli yönlerden değerlendirmektedir. Bu çalışma astaksantinin gelecekteki klinik araştırmalarda ve sağlık uygulamalarında nasıl değerlendirilebileceğine dair önemli bir temel sunar. Özellikle yaşlanan nüfusun arttığı bir dönemde, astaksantin gibi doğal bir antioksidanın hastalıkların önlenmesi ve tedavisindeki potansiyeli üzerinde durulmaktadır.
Prosedur Perolehan Hak Pakai di atas Tanah Hak Milik Menurut Hukum Tanah Nasional untuk Menjamin Kepastian Hukum bagi Orang Asing [Procedure to Obtain Right of Use of Freehold Land According to National Land Law to Guarantee Legal Certainty for Foreigners]
Authors: Christie Gracia , Merlim Valerie , Widjojo Anne Gunadi Martono
Published: November 2023

Indonesia has a prohibition on ownership of freehold land by foreigners. Foreign citizens who are domiciled in Indonesia and want to obtain land rights can obtain a right of use with a period of time. This research's purpose is to analyze procedure for foreigners to obtain Right of Use of freehold land with time limitation in Indonesia, and the role of Land Deed Official (PPAT) in the making of the deed of Right of Use of freehold land with time limitation. This research is empirical normative research with data  from literature study and interviews. Type of approach that used in this research is systematic of law. Foreign citizens domiciled in Indonesia can have a Right of Use with a period of time on freehold land must fulfill the requirements and procedures in accordance with Indonesian laws and regulations. This is to ensure the achievement of legal certainty. In the acquisition of the right of use on freehold land, the role of the land deed official as a public official authorized to make deeds for the acquisition of the right of use on freehold land is necessary. Unfortunately, in practice there are still land deed officials who do not follow the procedures of Right of Use in accordance with the laws and regulations.

Bahasa Indonesia Abstrak: Di Indonesia terdapat larangan kepemilikan tanah Hak Milik oleh orang asing. Warga Negara Asing yang berkedudukan di Indonesia dan ingin memperoleh Hak Atas Tanah dapat memperoleh Hak Pakai dengan jangka waktu. Penelitian ini bertujuan untuk menganalisis prosedur bagi WNA untuk memperoleh Hak Pakai di atas tanah Hak Milik dengan jangka waktu di Indonesia, serta peran Pejabat Pembuat Akta Tanah (PPAT) dalam pembuatan Akta atas Hak Pakai di atas tanah hak milik dengan jangka waktu tertentu. Penelitian ini adalah penelitian normatif empiris dengan data yang diperoleh dari studi kepustakaan dan wawancara. Jenis pendekatan dalam penelitian ini adalah pendekatan sistematika hukum. Warga Negara Asing yang berkedudukan di Indonesia dapat mempunyai hak pakai dengan jangka waktu di atas tanah hak milik harus memenuhi syarat dan prosedur sesuai peraturan perundang-undangan Indonesia. Hal itu dilakukan agar tercapainya kepastian hukum. Dalam perolehan hak pakai di atas tanah hak milik perlu adanya peran Pejabat Pembuat Akta Tanah sebagai pejabat umum yang diberikan kewenangan untuk membuat akta guna perolehan hak pakai di atas tanah hak milik. Tetapi sangat disayangkan, dalam praktik masih ada Pejabat Pembuat Akta Tanah yang tidak mengikuti prosedur hak pakai sesuai peraturan perundang-undangan.
Tanggung Jawab Notaris Terhadap Akta Autentik yang Dibuat Tanpa Dihadiri Pihak Penghadap [Notary’s Responsibilities of Authentic Deed not Made in the Presence of the Party]
Authors: Thomas Thomas
Published: November 2023

An authentic deed is a perfect piece of evidence, which means that an authentic deed has physical, formal and material evidentiary power in accordance with the provisions based on Article 1886 of the Civil Code. Notaries play an important role in the process of making an authentic deed, the provisions of which are regulated in general law as well as the code of ethics attached to Notaries. However, sometimes when making an authentic deed, various problems are often found in the preparation process, one of which is the carrying out of the authentic deed without the presence of the party present. This research intends to examine the responsibilities and legal consequences of this problem. This research is normative juridical research using secondary data through statue approach case approach. It was found that the Notary violated the Law of Notary Position, has a number of responsibilities, and authentic deeds made under such conditions also have legal consequences that are detrimental to the parties to the deed.

 

Bahasa Indonesia Abstrak: Akta autentik merupakan suatu alat bukti yang sempurna yang artinya akta autentik memiliki kekuatan pembuktian secara lahiriah, formal dan materiil sesuai ketentuan berdasarkan Pasal 1886 KUH Perdata. Notaris berperan penting dalam proses pembuatan suatu akta autentik yang mana ketentuannya diatur dalam undang-undang secara umum begitu juga dengan kode etik yang melekat terhadap Notaris. Namun terkadang dalam pembuatan akta autentik sering ditemukan berbagai masalah dalam proses penyusunannya, salah satunya adalah dengan dilaksanakannya pembuatan akta autentik tanpa dihadiri pihak penghadap. Penelitian ini bermaksud untuk menelaah mengenai tanggung jawab dan akibat hukum atas masalah tersebut. Penelitian ini adalah penelitian yuridis normatif dengan menggunakan data sekunder melalui pendekatan undang-undang dan pendekatan kasus. Ditemukan bahwa Notaris melanggar UUJN, memiliki sejumlah tanggung jawab, dan terhadap akta autentik yang dibuat dengan kondisi demikian juga memiliki akibat hukum yang merugikan para pihak dalam akta tersebut.
Fibromiyalji Tanılı Hastalarda Denge ve Postürün Değerlendirilmesi
Authors: ŞAHİN Onur , TAŞTEKİN Nurettin , ULUÇAM Enis , KARAHAN Menekşe , SÜT Necdet , BİRTANE Murat
Published: November 2023

Denge sorunları son zamanlarda Fibromiyalji (FMS)’li hastalarda dikkat çeken semptomlar arasında gösterilmiştir. Bu çalışmada fibromiyalji hastalarında denge ve postürün değerlendirilmesini, bu durumların varlığı ile fibromiyalji şiddeti arasındaki ilişkiyi değerlendirme amaçlanmıştır. Çalışmaya TÜTF Hastanesi Fizik Tedavi ve Rehabilitasyon polikliniğine başvuran FMS tanılı 30-55 yaş aralığındaki 45 birey ve kontrol grubu olarak 44 birey dahil edildi. Olguların sosyo-demografik özellikleri, şikâyet ve tanı süresi kaydedildi. Vizüel analog skala (VAS) ile ağrı şiddeti, Fonksiyonel durum için Fibromiyalji Etki Skalası (FEA), Fibromiyalji Semptom Şiddet Skalası, Yaygın Ağrı İndeksi sorgulanarak kaydedildi. Olguların dinamik dengeleri Berg denge testi, statik dengeleri ise tek bacak üstünde durma testi ile değerlendirildi. Zebris CMS-20P-2 cihazı ile bilgisayar ortamında üç boyutlu ultrasonik sistem ile omurga postür analizi yapıldı. FMS grubunda sağ ve sol tek ayak üzerinde durma süreleri ile toplam Berg Denge Ölçeği sonuçlarının anlamlı derecede daha düşük bulunmuştur. Berg Denge Skoru ile Toplam FEA skoru, Semptom Şiddet Skalası skoru A, Fibromiyalji Şiddet skoru ve Total Gövde İnklinasyon Açısı arasında ters yönde ve orta düzeyde anlamlı ilişki olduğu bulduk. Omurga postür analizi ile hasta ve kontrol grupları arasındaki postür analizi sonuçlarının farklı saptanmamıştır. Sonuç olarak FMS’li hastalarda denge bozukluğunun sağlıklı bireylere göre daha sık rastlandığını tespit ettik. Postür analizinde her iki grup arasında anlamlı fark saptayamadık. Özellikle postür srunlarını ortaya koyabilmek için büyük popülasyonlu çalışmalara ihtiyaç vardır.
Optimizing Noise Levels in the Inpatient Room at Bumi Panua Pohuwato Hospital
Authors: Eran Moh. , Nurmiah Nurmiah
Published: November 2023

Bumi Panua Hospital is the only hospital in Marisa District, Pohuwato Regency. In each building, there is a lot of activity going on between patients, nurses, doctors, and visitors who arrive. In addition, the vehicle parking location which is right in front of the hospital inpatient room can cause noise which can reduce patient comfort. The noise level of the hospital must be in accordance with its function and meet health requirements, especially in inpatient rooms. The aim of this research is to carry out measurements to optimize noise levels in patient inpatient rooms at Bumi Panua Pohuwato Hospital. The method used in this research is a descriptive analysis method with a quantitative approach and acoustic simulation using the I-SIMPA application. From the results of Background Noise and Reverberation Time research on class III and II inpatient rooms at Bumi Panua District Hospital. Pohuwato. The condition of background noise in class III and II inpatient rooms is not good because the (dB) produced by background noise in the room is quite high, above 66 dB and exceeds the recommended standard regarding (dB) background noise in patient rooms. It should be below 40 - 45 dB. Based on the simulation results, the reverberation time in class III and class II inpatient rooms produces reverberation time that exceeds the recommended standard due to not using acoustic materials and the shape and volume of the room which causes sound reflection to occur for longer. Optimization is carried out to reduce the reverberation time so that the sound intensity in the room is not too long and can reduce background noise in the patient room.
The Visual Integrity Approach in Historical City Development (A Comparative Study between Istanbul, Vienna, Kyoto and Yogyakarta)
Authors: Budiman Hanif , Jutta Mode , Yuli Nensi Golda
Published: November 2023

Architecture and city landscape study becomes interesting if it is associated with factors that accompany the process of growth and development of the city. The city of Yogyakarta has a unique landscape, derived from the authentic history of the region's landscape configuration, and unique geographical elements, and supported by socio-cultural life based on historical traditions. The pressures and challenges of this condition cannot be avoided with the development of the area, the increasing density, and the emergence of new urban spaces which have physical and visual aspects. This study aims to know the strategy for strengthening visual integrity through the natural and cultural landscape of Yogyakarta as a historic city. The study was discussed by analyzing the basic aspects of visual integration in the form of sequence, orientation, continuity, and complexity. Comparison method between 3 historical cities Vienna, Kyoto, and Istanbul, considered to have the same natural, physical and cultural components. The discussion focuses on descriptive analysis to get the best practices for Yogyakarta city planning. The results of this study show the importance of maintaining the visual integrity of the landscape of the Historical Yogyakarta City area in the face of the pressures of urban development and maintaining the sustainability of the authenticity of city basic values.
A Research Review on Semantic Interoperable Archetype Models, Approaches & Methods Implemented for Electronic Health Record Systems in Medical Healthcare
Authors: Harpreet Rai , Yadav Rimmy
Published: November 2023

Semantic interoperability is a foundational concept in modern healthcare, enabling seamless communication and meaningful data exchange across diverse EHR systems. At the heart of this concept lies archetype clinical information models, which serve as standardized templates to structure and encode clinical data, ensuring consistency and shared understanding among various healthcare stakeholders. This review paper delves into the intricacies of Electronic Health Records (EHRs) within the context of semantic interoperability and the pivotal role played by archetype clinical information models. Drawing from a wealth of recent research, this review paper examines the theoretical underpinnings of semantic interoperability. By surveying the literature, it synthesizes the diverse approaches and methods employed to achieve semantic interoperability within EHR systems. Furthermore, this review does not shy away from addressing the significant challenges that persist in this arena. These challenges encompass issues related to data quality, governance, resistance to change, and the scalability and integration hurdles that healthcare organizations encounter in their quest for interoperable EHR systems. Through a comprehensive review of relevant research papers from esteemed sources including PubMed, ScienceDirect, and Taylor & Francis, the paper offers a comprehensive understanding of the approaches and methods employed in this domain. This analysis encompasses a time frame ranging from 2015 to 2023, ensuring an up-to-date assessment of the field. By presenting a well-rounded picture of the field, this review paper offers valuable insights for healthcare stakeholders, researchers, and practitioners. It underscores the enduring importance of semantic interoperability in EHR systems, not only in advancing patient care, clinical decision support, and healthcare operations but also in driving data-driven innovations in the dynamic and ever-evolving medical healthcare sector. This comprehensive examination sets the stage for future advancements in the pursuit of truly interoperable and data-driven healthcare systems.
Derivation of Kokumi G-glutamyl Peptides and Volatile Aroma Compounds from Fermented Cereal Processing By-Products for Reducing Bitterness of Plant-Based Ingredients
Authors: Rodriguez Valerón Nabila , Mak Tiffany , Jahn Leonie Johanna , Arboleya Juan Carlos , Sorensen Pia
Published: November 2023

Current food production methods and consumption behaviours are unsustainable and contribute to environmental harm. One example is food waste  around 38% of food produced is wasted each year. Here, we show that two common food waste products, wheat bran and brewer’s spent grain, can successfully be upcycled via miso fermentation. During the fermentation process, kokumi g-glutamyl peptides, known to increase mouthfulness, are produced; these include g-ECG (oxidized), g-EVG, g-EV, g-EE, g-EF, and g-EL. The profiles of kokumi peptides and volatile aroma compounds are correlated with koji substrate, pH, and enzymatic activity, offering straightforward parameters that can be manipulated for increasing the abundance of kokumi peptides during the fermentation process. Correlation analysis demonstrates that some volatile aroma compounds, such as fatty acid ethyl esters, are correlated with kokumi peptide abundance and may be responsible for the fatty, greasy, and buttery aroma. Consumer sensory analysis conveys that the bitter taste of vegetables, such as that in endives, can be dampened when miso extract containing kokumi peptides is added. This suggests that kokumi peptides, along with aroma volatile compounds, can enhance the overall flavor in plant-based products. This study opens new opportunities for cereal processing by-product upcycling via fermentation, ultimately having the potential to promote a plant-based diet.
Children’s Privacy in the Digital World: A Review of the Law on the Use of Technology Child
Authors: Arnetta Ladinda Daffa , Fathyasani Ghivarri Adinda , Suryawijaya Tito
Published: November 2023

In article 16 of the United Nations Convention (UN), or the United Nations Convention on the Rights of the Child (UNCRC), which is usually called the Convention on the Rights of the Child, outlines the right of every child to privacy and protection against violations of privacy related to the home. , family, communication, and their good name. Children's privacy, especially when it comes to personal data, requires strict boundaries. Current digital developments influence children's parenting and thinking patterns with potential negative impacts. Children can be targets of abuse in the digital world. Children's personal data is often used until they become independent. This research, using normative legal methods, aims to analyze regulations related to the protection of children's personal data in the digital era. Therefore, updates are needed in the laws and regulations governing children's personal data to safeguard their privacy rights in accordance with the UNCRC.
A Retrospective Observational Study to Evaluate Adjacent Segmental Degenerative Change with the
Dynesys-Transition-Optima Instrumentation System
Authors: Li Chi-ruei , Chen Shih-Hao , Chen Wen-Hsien , Tsou Hsi-Kai , Tzeng Chung-Yuh , Chen Tse-Yu , Lin Mao-Shih
Published: November 2023

Study design: Retrospective observational study. Objectives: To evaluate the change in adjacent segment disease (ASD) after hybrid dynamic stabilization with Dynesys-Transition-Optima (DTO). Methods: In 2012–2020, 115 lumbar spinal stenosis patients with spondylolisthesis re-fractory to nonsurgical management received hybrid dynamic stabilization with DTO system in a single medical center from a single neurosurgeon. After excluding those who did not receive L3–L4 dynamic stabilization and L4–L5 transforaminal lumbar interbody fusion fixation and those with incomplete postoperative data (n = 84), the 31 patients studied received follow-up vis-its at 6, 12 and 24 months postoperatively. Radiological assessment applied at the L2–L3, L3–L4 and L5–S1 segments separately included disc height, listhesis distance and angular change while in motion. Implant failure and screw loosening sign were both documented. Results: In the L3–L4 segment, the listhesis distance appeared 1 year after the operation; however, alterations in other segments showed at 6 months. At 2 years, the L3–L4 segment showed significantly less increase in listhesis distance and relatively less disc height reduction than other segments. In motion an-gular change, only the L3–L4 segment had a significant decrease at 2 years. Only the L3–L4 seg-ment maintained negative growth over 2 years in time-dependent assessment of motion angular change. Conclusions: In our study, disc height decreased, listhesis distance increased less and ASD changed later at the index level than the L2–L3 and L5–S1 levels. Angular change was re-duced at the index level while in motion. Although ASD was not significantly prevented, index level degeneration was both minor
Immunoblotting Identification of Diagnostic Antigens of Paragonimus westermani Type 1 for Detection of Human Pulmonary Paragonimiasis in North East India
Authors: Devi Kangjam Rekha , Deka Archana , Mukherjee Debdutta , Kaur Harpreet , Narain Kanwar
Published: November 2023

Human pulmonary paragonimiasis, an emerging concern in North East India, frequently masquerades as pulmonary tuberculosis due to clinical and radiological similarities, leading to diagnostic challenges. This research was aimed to harness the immunoblotting technique to discern immunodiagnostic protein antigens from both adult worm and excretory-secretory (ES) extracts of the prevalent Paragonimus westermani type 1 in Arunachal Pradesh, North East India. We studied the time kinetics of immunoreactive patterns in relation to the duration of infection in rodent models. Immunoblot analyses were also conducted using sera from ELISA positive patients confirmed with paragonimiasis, facilitating the selection of antigenic extracts with diagnostic potential. Further, ES proteins antigens were subjected to 2D- immunoblot analysis and immunoreactive protein spots identified by MALDI-TOF MS. Immunoreactivity patterns of ES antigens with sera of paragonimiasis positive patients were detailed, and specific immunoreactive protein antigens were pinpointed using peptide mass fingerprinting (MALDI-TOF). This work underscores the enhanced diagnostic accuracy when combining ELISA with immunoblotting for pulmonary paragonimiasis in regions like North East India, marked by co-existing helminth infections.
Thickness Optimization of Zn0.9Mg0.1O Nanoparticle Electron Transport Layer for High-Performance Top-Emission Quantum Dot Light-Emitting Diodes
Authors: Jang Gyeong-Pil , Yang Ji-Hun , Kim Su-Young. , Chae Young-Bin , Choi Hyuk-Doo , Moon Dae-Gyu , Kim Chang-Kyo
Published: November 2023

Zn0.9Mg0.1O nanoparticle (NP) were employed as electron transport layers (ETLs) with varying thicknesses to investigate their influence on the efficiency of the top-emission quantum dot light-emitting diodes (TE-QLEDs) fabricated inside the bank. An increase in the thickness of the Zn0.9Mg0.1O NP ETL led to a decrease in the concentration of oxygen vacancies, reducing the conductivity of the Zn0.9Mg0.1O and resulting in lower current density in the TE-QLEDs. The decrease in conductivity of Zn0.9Mg0.1O NP ETL was confirmed through electron-only device (EOD) characterization. Furthermore, it was noted that when the thickness of Zn0.9Mg0.1O NP ETL was 30 nm, the concentration of hydroxyl species reached its minimum. By minimizing the presence of hydroxyl species, exciton quenching at the quantum dot (QD) and Zn0.9Mg0.1O NP ETL interface was minimized, enhancing charge balance within the QD, significantly improving the efficiency of QLED. We successfully demonstrated that TE-QLED with a 30 nm-thick Zn0.9Mg0.1O NP ETL exhibits outstanding performance, achieving a maximum current efficiency of 91.92 cd/A and a maximum external quantum efficiency of 21.66%. These results suggest that Zn0.9Mg0.1O NP ETL, when tailored to an appropriate thickness, can serve as an ETL for TE-QLEDs, effectively suppressing exciton quenching and enhancing the charge balance in the TE-QLEDs.
Intelligent Feedrate Optimization using an Uncertainty-aware Digital Twin within a Model Predictive Control Framework
Authors: Kim Heejin , Kontar Raed , Okwudire Chinedum
Published: November 2023

The future of intelligent manufacturing machines involves autonomous selection of process parameters to maximize productivity while maintaining quality within specified constraints. To effectively optimize process parameters, these machines need to adapt to existing uncertainties in the physical system. This paper proposes a novel framework and methodology for feedrate optimization that is based on a physics-informed data-driven digital twin with quantified uncertainty. The servo dynamics are modeled using a digital twin, which incorporates the known uncertainty in the physics-based models and predicts the distribution of contour error using a data-driven model that learns the unknown uncertainty on-the-fly by sensor measurements. Using the quantified uncertainty, the proposed feedrate optimization maximizes productivity while maintaining quality under desired servo error constraints and stringency (i.e., the tolerance for constraint violation under uncertainty) using a model predictive control framework. Experimental results obtained using a 3-axis desktop CNC machine tool and a desktop 3D printer demonstrate significant cycle time reductions of up to 38% and 17 respectively, while staying close to the error tolerances compared to the existing methods.
Sustainability in Healthcare Sector: The Dental Aligners Case
Authors: Caelli Chiara , Tamburrino Francesco , Brondi Carlo , Razionale Armando Viviano , Ballarino Andrea , Barone Sandro
Published: November 2023

The study conducts a comparative life cycle assessment (LCA) analysis to assess the environmental impact of two different manufacturing processes used to produce transparent dental aligners. The former method consists of thermoforming a polymeric disc over 3D printed, customized models, while the second, more innovative approach involves the direct printing of aligners using additive manufacturing (AM), specifically applying digital light processing (DLP) technology. The analysis results highlight how adopting direct printing through AM brings significant advantages in terms of environmental sustainability, thanks to the substantial reduction in raw materials and electricity consumption. These drops translate into decreased potential environmental impacts across all impact categories considered within the EF 3.1 method. Furthermore, lowering the amount of raw materials needed in the direct printing process contributes to a notable decrease in the overall volume of waste generated, emphasising the environmental benefits of this innovative technique.
Opinion: Global Chronic Disease Burden Can Be Reduced by Taking Care of Our Mitochondria
Authors: Gopalakrishnan Vanathi
Published: November 2023

This is an opinion piece based on observations from more than two decades of biomedical data mining insights studying health and disease. It has led me to reevaluate modern life and how lived experiences in many parts of the world are being questioned and now answered through the various technological advances that have taken place in biomedical science. Our mitochondria are multi-faceted and the next generation will need to ensure that they develop a strong understanding from a scientific basis for how they are important to our health. The mind-body connection is also now being investigated through researching the networks of mitochondrial bioenergetics. This article provides a brief introduction to how we can reduce chronic disease burden globally, by introducing a simple first algorithm for healthy aging. This work is aimed to jump start the collection of Algorithms for Healthy Aging (AHA) in the context of global populations in their locally lived generational experiences, which may have underlying scientific bases that are yet to be discovered and validated.
Assessment of Metal Contamination with Seasonal Variation in Sediments of Narmada River (India) Using Pollution Indices
Authors: Rahi Dal Chand , Chandak Rajeev , Vishwakarma Amit
Published: November 2023

This study aimed to assess the presence of metal contamination in the sediments of the Narmada River by considering seasonal variations. In this context, samples were gathered from six stations along the river in 2021–22. To assess the various metals including Li, Na, Mg, Al, Ca, Fe, Cu, Zn, Co, and Ni by utilizing ICP-MS. Sediment contamination was assessed by utilizing indices like contamination factor (CF), pollution load index (PLI), geo-accumulation factor (Igeo), and enrichment factor (EF). The observed order of metals concentration revealed that metals Fe>Al>Mg>Ca>Na>Cu>Zn>Co>Ni>Li. The seasonal variation reveals metals Al, Fe, Cu, Zn, and Ni exhibit the highest concentrations during the monsoon and metals Li and Co, the highest concentration in the post-monsoon, while metals Na, Mg, and Ca, exhibit their peak concentration during the pre-monsoon. The findings from CF, PLI, Igeo, and EF indicate that there were low to moderate contaminations, metal pollution exists, uncontaminated to moderate contaminations, and minor enrichment. The cluster analysis revealed the source of contamination was anthropogenic, marine, and fertilizer activities. Additionally, Correlation matrix was employed to establish connections between metals. The findings of this research are to understand the metal contamination and potential carcinogenicity in the sediment of Narmada River.