bluuebunny/crossref_metadata_2025 huggingface dataset:
Laser therapy in the treatment of iatrogenic lesions of oral mucus membrane - literature review and case study
Authors: Chochowska Małgorzata , Grabowska Katarzyna
Published: September 2023

Szczególną przyczyną zapalenia błony śluzowej jamy ustnej (oral mucositis, OM) są uszkodzenia jatrogenne (chemiczne lub mechaniczne). W leczeniu OM wykorzystuje się laseroterapię biostymulacyjną/niskoenergetyczną (low level laser therapy, LLLT) ze względu na działanie przeciwbólowe, przeciwzapalne i biostymulacyjne. W pracy przedstawiono przegląd literatury dotyczący wykorzystania LLLT w fizjoterapii stomatologicznej (także u pacjentów onkologicznych) oraz opis przypadku pacjentki (l. 42) z rozległym jatrogennym OM powstałym podczas leczenia endodontycznego. Zastosowano LLLT (830 nm, 400 mW, III B, 20 J/cm2, emisja ciągła, 200 J; 8:20 min; 5 zabiegów). Przed każdym LLLT oraz po tygodniu od 1. zabiegu (w sumie 6 razy) dokonano oceny z wykorzystaniem autorskiej Skali Bólu Jamy Ustnej, Skali Laitinena oraz dokumentacji fotograficznej. Już po 1., a szczególnie wyraźnie po 2. LLLT, odnotowano spadek bólu zarówno w Skali Bólu Jamy Ustnej (odpowiednio o 20 pkt/% i 68 pkt/%), jak i Skali Laitinena (odpowiednio o 5 pkt. i 10 pkt.) w stosunku do stanu początkowego. Po 7 dniach od 1. LLLT pacjentka odczuwała jedynie lekki dyskomfort podczas jedzenia (1 pkt/% w Skali Bólu Jamy Ustnej). Wyniki przedstawionego leczenia oraz dane literaturowe zachęcają do wykorzystania LLLT w OM.
Renal amyloidosis in ankylosing spondylitis - an unusual indication for a renal replacement therapy
Authors: Rogalewicz Liwia , Rupińska Anna , Grech Aleksander , Niemczyk Stanisław
Published: September 2023

Amyloidoza AA stanowi potencjalnie poważne powikłanie przewlekłych chorób zapalnych. Jedną z możliwych przyczyn tej choroby jest zesztywniające zapalenie stawów kręgosłupa (ZZSK). Amyloidoza to stosunkowo rzadkie powikłanie wspomnianej spondyloartropatii. Opóźnienie diagnozy i wdrożenia leczenia choroby podstawowej może prowadzić do uszkodzenia przez złogi amyloidu wielu narządów – najczęściej nerek. Zajęcie nerek, które zwykle objawia się białkomoczem oraz zespołem nerczycowym (ZN), może prowadzić do ich niewydolności. Przedstawiamy opis przypadku 45-letniego pacjenta, u którego 25-letni wywiad nieleczonego ZZSK skutkował rozwojem
amyloidozy nerek i koniecznością terapii nerkozastępczej. W trakcie diagnostyki pacjent początkowo negował dolegliwości ze strony stawów. Rozpoznanie ZZSK postawiono dopiero w ramach poszukiwania przyczyn amyloidozy AA przebiegającej pod postacią zespołu nerczycowego.
Optical solitons of the complex Ginzburg-Landau equation having dual power nonlinear form using $\varphi^{6}$-model expansion approach
Authors: ISAH Muhammad Abubakar , YOKUŞ Asıf
Published: September 2023

This paper employs a novel $\varphi ^{6}$-model expansion approach to get dark, bright, periodic, dark-bright, and singular soliton solutions to the complex Ginzburg-Landau equation with dual power-law non-linearity. The dual-power law found in photovoltaic materials is used to explain nonlinearity in the refractive index. The results of this paper may assist in comprehending some of the physical effects of various nonlinear physics models. For example, the hyperbolic sine arises in the calculation of the Roche limit and the gravitational potential of a cylinder, the hyperbolic tangent arises in the calculation of the magnetic moment and the rapidity of special relativity, and the hyperbolic cotangent arises in the Langevin function for magnetic polarization. Frequency values, one of the soliton's internal dynamics, are used to examine the behavior of the traveling wave. Finally, some of the obtained solitons' three-, two-dimensional, and contour graphs are plotted.
Two-dimensional Cattaneo-Hristov heat diffusion in the half-plane
Authors: İSKENDER EROĞLU Beyza Billur
Published: September 2023

In this paper, Cattaneo-Hristov heat diffusion is discussed in the half plane for the first time, and solved under two different boundary conditions. For the solution purpose, the Laplace, and the sine- and exponential- Fourier transforms with respect to time and space variables are applied, respectively. Since the fractional term in the problem is the Caputo-Fabrizio derivative with the exponential kernel, the solutions are in terms of time-dependent exponential and spatial-dependent Bessel functions. Behaviors of the temperature functions due to the change of different parameters of the problem are interpreted by giving 2D and 3D graphics.
K Vitamini ve Bilişsel Performans: Mini Bir Derleme
Authors: EJDER Zeynep Bengisu , EKİCİ Emine Merve
Published: September 2023

K vitamini yağda çözünen bir vitamin olup doğada filokinon (K1), menakinon (K2) ve sentetik analog olarak da menadion (K3) formunda kullanılmaktadır. Genellikle koagülasyon üzerine rolü olduğu bilinen K vitamininin günümüzde kardiyovasküler hastalıklar, osteoporoz, vasküler kalsifikasyon, kanser, diyabet ve glisemik kontrol ile de ilişkisi olduğu bildirilmektedir. Aynı zamanda metabolizmada K vitaminine bağımlı proteinlerin karboksilasyonundan da sorumlu olan vitaminin alınımı son zamanlarda daha çok dikkat çekmektedir. Yapılan çalışmalarda K vitamininin beyinde miyelinizasyonun yoğun olduğu bölgelerde Menakinon-4 (MK-4) formunda bulunduğu saptanmış olan K vitamini eksikliğinin bilişsel performans bozukluğunun patogenezinde rol alabileceği bildirilmiştir. K vitamininin bu etkisini Gas-6 ve protein S gibi moleküller aracılığıyla veya nöronları oksidatif stres hasarına karşı koruyarak gösterdiği düşünülmektedir. Bu derlemede K vitamininin bilişsel performans üzerine etkilerini incelemek amaçlanmaktadır.
The evaluation of the inflammatory parameters in the patients with controlled epilepsy versus the patients with resistant epilepsy
Authors: Gesoglu Demir Tülin , Ethemoglu Ozlem , Agırcan Dilek
Published: September 2023

Objective: This study aims to evaluate the effects of C-reactive protein (CRP), albümin, mean platelet volume (MPV) values and neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLO), MPV/PLT ratio, CRP / Albumin ratios on seizure type and seizure control in epilepsy patients who are refractory or non-refractory to treatments.
Methods: The study comprised 43 refractory epilepsy, 64 well-controlled epilepsy patients and control group including 68 healthy individuals. Mean platelet volume (MPV), platelet, CRP, and albumin values of the patients were studied. CRP / albumin ratio (CAR), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLO), and the MPV/ PLT ratio were determined.
Results: The mean serum CRP and CAO were found to be significantly higher in refractory epilepsy patients compared to well-controlled epilepsy patients and healthy control groups, while MPV and albumin levels were found to be significantly lower.
Conclusions: Serum CRP and CAO were found to be significantly higher in refractory epilepsy patients compared to well-controlled epilepsy patients and healthy control groups, while MPV and albumin levels were found to be significantly lower. In addition, this inflammatory activity increases as the frequency of seizures increases and the duration of the disease increases. These findings suggest that increased inflammatory response may affect the patient’s prognosis. In light of these findings, we think new treatment strategies that control the inflammatory response are necessary for patients with refractory epilepsy.
Association between plaque characteristics and severity of acute ischemic stroke
Authors: Abhas Kumar  , Pushpendra Nath Renjen  , Harsh Rastogi  , Dinesh Mohan Chaudhari  , Priyal  , Arushee Bhatnagar  , Kamal Ahmad  , Anjali Mishra
Published: September 2023

Background & Objective: Cerebrovascular atherosclerotic disease is the major cause of ischemic stroke and transient ischemia attack (TIA). Atherosclerosis commonly affects intracranial and extracranial carotid arteries simultaneously. Plaque characteristics are significantly associated with the severity of ischemic stroke. We studied the characteristics of atheromatous plaques in ischemic stroke patients and correlated characteristics of atheromatous plaques with the patient’s National Institute of Health Score (NIHSS) at the time of presentation with ischemic stroke.
Methods: We conducted a cross-sectional analysis of 83 in-patient adults presenting with complaints of acute stroke within seven days of stroke. Those who consented were included in the study. The management, investigations and treatment of the cases were according to the hospital’s stroke protocol. An NIHSS score was calculated. MRI brain and MRA/HR-MRI (vessel wall imaging) were done as stroke protocol. The data was analyzed using SPSS 22.0 and R.3.2.0.
Results: A total of 83 patients were enrolled, of which 59% were males and 41% were females, with a mean age of 52.8 ± 11.6 years and 54.5 ± 11 years, respectively. The mean NIHSS score, internal carotid artery stenosis, and lumen area of ICA (mm2) for all plaques were statistically significant (p< 0.001).
Conclusion: We established a strong association between carotid atherosclerotic plaque characteristics and ischemic stroke severity. We found that a CT scan is better for diagnosing calcified plaques than HR-MRI.
The frequency of polyneuropathy according to dialysis type and its effect on quality of life in chronic renal failure
Authors: Kocaoğlu Seher
Published: September 2023

Objective:This study aimed to evaluate patients with chronic renal failure who underwent peritoneal dialysis (PD) or hemodialysis (HD). We examined the association of dialysis type on the frequency of polyneuropathy and quality of life in these patients.
Methods: A total of 61 patients, 41 of whom were PD and 20 HD patients, were included in the study. Neuropathy were evaluated with the Neuropathy Symptom Score (NSS), and quality of life was evaluated with the Short Form -36 (SF- 36). Electrophysiological examinations of all patients were performed.Chi-square test and Independent Samples t-test were used for comparisons between groups. A p value of <0.05 was considered statistically significant.
Results: There was no statistically significant difference between the groups in terms of NSS values (p>0.05). In the evaluation of SF-36 parameters the values were significantly better in the HD group (p<0.05). In the electrophysiological examination, polyneuropathy was detected in 60% of the PD group vs 30% of the HD group.
Conclusion: In patients with chronic kidney disease on dialysis treatment; HD appeared to have less neuropathy and better quality of life.
Estimating a two-year recurrence risk of ischemic stroke based on Essen Stroke Risk Score and retinal characteristics
Authors: Zhuo Yuanyuan , Pi Min , Huang Xingxian , Liu Limin , Yang Zhuoxin
Published: September 2023

Objectives: Prediction of recurrence risk after initial ischemic stroke helps improve patient outcomes. We estimated the validity of combining the Essen Stroke Risk Score (ESRS) with retinal characteristics to predict the two-year recurrent risk of ischemic stroke.
Methods: A prospective cohort study was conducted at Shenzhen Traditional Chinese Medicine Hospital. Patients with initial ischemic stroke were recruited. ESRS was measured, and fundus photographs were taken by trained physicians. All patients were followed up for 2 years to determine the outcome of recurrent stroke. Logistic models were built using ESRS alone and combined with ESRS and retinal characteristics. The prognostic value of recurrence risk was evaluated by calculating the area under the receiver operating characteristic curve.
Results: The total recurrence rate of ischemic events within 2 years was 20%. The risk of recurrence was significantly higher in patients with an ESRS score of >2. Regarding retinal characteristics, patients with recurrent stroke had a lower mean asymmetry index of venules (0.76 vs. 0.77, P=0.00) and bifurcation coefficient of venules (1.29 vs. 1.28, P=0.03) but a higher mean occlusion of arterioles (0.11 vs. 0.13, P=0.01). The area under the curve was 0.5985 based on the logistic regression model with ESRS alone to 0.7294 for the model with both ESRS and retinal characteristics. This study was registered in the Chinese Clinical Trial Registry (registration no. ChiCTR1800019648).
Conclusion: A model combining ESRS with retinal characteristics can accurately predict the risk of recurrent stroke.
Papilledema with acute profound visual loss in capillary haemangioma of the sphenoid sinus with sellar and parasellar extensions – a triple rarity presentation
Authors: Zahari Khalilah Mastura , Masnon Nurul 'Ain , Othman Othmaliza , Abd Latif Kartikasalwah , Mohd Dusa Noraini
Published: September 2023

Intracranial capillary haemangioma (ICH) is rare. We report a unique case of a young man with ICH who was presented with papilledema and acute profound visual loss. A 27-year-old man presented with bilateral eye reduced vision for 2 weeks with headaches. Examination showed optic disc swelling with severe visual loss. Neuroimaging revealed a vascular tumour epicentre at the sphenoid sinus with sellar and parasellar extensions. The patient developed massive bleeding during transsphenoidal surgery, in which intraarterial embolization was done, followed by a second surgery. Histopathology revealed benign capillary haemangioma. There was minimal visual improvement. He then developed tumour recurrence at 4 months postoperatively. ICH may cause rapid and acute blindness. Management is challenging with a guarded visual prognosis.
RNF213 p.R4810K variant in moyamoya disease in adults and children from a Malaysian tertiary center
Authors: Ho Jun Hui , Tan Kay Sin , Lim Wei Kang , Fong Choong Yi , Toh Tsun Haw , Lau Kar Foo , Chan Zhen Shun , Tai Sharon Mei Ling , Rahmat Kartini , Tarmizi Thayaparan Farah Diana , Murugesu Sumitha , Ng Ching Ching
Published: September 2023

Background: Ring finger protein 213 (RNF213) is a major susceptibility gene for moyamoya disease (MMD). A single nucleotide variant known as c.14429G>A (p.R4810K, rs112735431) is strongly associated with MMD, weakly associated with moyamoya syndrome (MMS) and intracranial atherosclerosis (ICAS) in East Asians. The percentage of patients carrying p.R4810K and the effect sizes vary between different racial backgrounds. We aimed to investigate the prevalence of p.R4810K in MMD, MMS, and ICAS patients in Malaysia.
Methods: We genotyped p.R4810K in DNA extracted from 9 MMD, 13 MMS, 15 ICAS cases, and 45 controls using TaqMan SNP genotyping assay. Clinical and neuroradiological data was collected for each patient and the distribution of genotype frequencies compared between cases and controls and tested for association.
Results: Two of seven (28.6%) Chinese MMD cases had heterozygous p.R4810K (GA) genotype. The remaining MMD cases (5 Chinese and 2 Malays), all 13 MMS, 15 ICAS cases and 45 controls had homozygous wild-type (GG) genotype. Higher frequency of GA genotype was observed in Chinese MMD patients compared with controls, indicating an association between p.R4810K and Chinese MMD subgroup under a dominant model (P=0.0398).
Conclusion: This is the first study reporting p.R4810K in a multiracial Asian population. The p.R4810K missense mutation was detected in MMD cases of Chinese descent in Malaysia. Further studies are needed to identify other susceptibility variants and genes in Malaysian patients with moyamoya and ICAS.
Comparison of vitamin D levels in children with motor development delay and asthma
Authors: DEDEOGLU Özge , KONUŞKAN Bahadır , CANSEVER Murat , Yayici Köken Özlem
Published: September 2023

Background & Objective: Vitamin D plays an important role in musculoskeletal health and is also potentially involved in the pathogenesis of chronic diseases. In this study, we aimed to determine the vitamin D status of children aged 2-6 years with motor developmental delay and compare them with asthmatic children.
Method: Serum 25-Hydroxy cholecalciferol 25 (OH) D vitamin levels of children were measured between June 2020 and September 2020. Vitamin D deficiency was defined as a serum 25 (OH) vitamin D level less than 20 ng/mL and insufficiency as levels between 20 and 30 ng/mL. The deficiency and insufficiency rates and mean 25 (OH) vitamin D levels between the two groups were compared.
Results: The study population included 818 children (192 children with asthma, 368 children with motor development delay and 258 healthy controls). There was no statistically significant difference between groups in terms of age and gender (p=0.130 and p= 0.082, respectively). Vitamin D deficiency and insufficiency were detected in one thirds of children with motor developmental delay (33.7%; 35.6% respectively). The rate of vitamin D deficiency of children with motor development delay between 24 - 47 months of age was found to be significantly higher than control and asthma group (p=0.001 and p=0.034).
Conclusions: Vitamin D deficiency and insufficiency were common between 2-6 years of age children with motor development delay. Acceleration of2 motor development between 24 - 47 months of age may be a cause of high incidence of D vitamin deficiency. Clinicians should check and optimize vitamin D status in children with motor development delay especially between 24 - 47 months of age.
Early detection of diabetic peripheral neuropathy using EMLA-induced skin wrinkling
Authors: Chuesawai Bennaree , Suwat Srisuwannanukorn
Published: September 2023

Background & Objective: Screening for early diabetic peripheral neuropathy (DN) is essential for foot ulcer prevention. The Semmes–Weinstein monofilament (SWMF) is commonly used to detect DN in Thailand. However, SWMF interpretation requires patient participation, which is susceptible to risk of error in patients with impaired cognitive function or uncooperative patients. In contrast, stimulated skin wrinkling (SSW) can be interpreted by trained investigators, which is more appropriate. This study aimed to investigate the utility of SSW using a eutectic mixture of local anesthetic (SSW-EMLA) for early DN diagnosis.
Methods: This cross-sectional study, recruited 102 patients with diabetes (DM group), 33 with diabetes with foot ulcer (DN control group), and 30 without diabetes (non-DN control group) from the Faculty of Medicine, Vajira Hospital, Navamindradhiraj University, Thailand, from February 3, 2021 to November 30, 2021. SSW was conducted by applying EMLA on the tips of the 2nd, 3rd, and 4th fingers of both hands. SWMF, sensory perception of pain (SPP), vibration perception threshold (VPT), joint position sense (JPS), and deep tendon reflexes (DTR) were also evaluated on the same day.
Results: The Interrater agreement of two investigators for SSW-EMLA was high with intraclass correlation coefficients of 0.87 (0.824–0.904) for the right hand and 0.874 (0.830–0.907) for the left hand. The kappa coefficients of agreement of SSW-EMLA for SPP, SWMF, VPT, JPS, and DTR testing were 0.411, 0.478, 0.714, 0.444, and 0.681, respectively. The sensitivity and specificity of SSW-EMLA testing for DN detection were 83.3%, was 85.7%, respectively.
Conclusion: The SSW-EMLA test can be considered as an alternative method for DN detection, due to its noninvasiveness, inexpensiveness (50THB), being a simple procedure, high sensitivity and specificity, and acceptable rater variation.
Hemophagocytic lymphohistiocytosis associated with sodium valproate
Authors: Zeng Xiang-Dong , Liu Ping , Hu Wen-Guang
Published: September 2023

Hemophagocytic lymphohistiocytosis(HLH) is known to have numerous causes, such as chronic inflammation, infection, malignancy, drug use, and primary or familial HLH. HLH triggered by valproate (VPA) has rarely been reported in the literature. Here we describe a pediatric patient with HLH induced by VPA. A 5-years-old girl presented to our center with recurrent fever accompanied by diffuse generalized rash after 2 weeks of taking oral VPA. Physical examination revealed hepatosplenomegaly; laboratory findings showed bicytopenia (hemoglobin and platelet), hemophagocytic cells on the bone marrow smear, hypofibrinogenaemia and hypertriglyceridaemia, and a high ferritin level. She was diagnosed to have HLH associated with VPA. She was treated with intravenous immunoglobulin, glucocorticoid and withdrawal of the sodium valproate, and she completely recovered. In conclusion, VPA can trigger HLH, a potentially fatal condition.
Sleep, eating and psychopathologies: Which one(s) may be associated with the development of metabolic syndrome in psoriasis patients through psoriasis quality of life?
Authors: TAS BETUL , Kabeloglu Vasfiye , Kacmaz Ugur , Kivanc Altunay Ilknur
Published: September 2023

Background: Psoriasis (PS) has many comorbidities including metabolic-syndrome (MetS) sleep and eating disorders and psychopathologies. Objectives: Investigating the relationship between the presence of MetS and sleep, eating and psychological pathologies in PS-patients through psoriasis quality of life (PSQoL).
Methods: In this cross-sectional and descriptive correlation study, besides demographics, MetS-parameters and comorbidities, PS-severity, PS related quality of life (PSQoL), sleep-quality (SQ), depression, anxiety, body image-related QoL (BIQoL), perceived stress, flourishing, social appearance anxiety and eating attitudes of subjects were examined with related scales. Data analyzed using SPSS software, according to two PS groups with and without MetS.
Results: Of 107 PS-patients, 68 were diagnosed with MetS. Mean-age and PS-duration were significantly higher in MetS (+) group. PS- severity was correlated with poor PSQoL, anxiety, depression, impairing flourishing, poor overall SQ and impairing in two sleep-subcomponents in MetS (+) group, whereas it was correlated with only poor PSQoL and poor overal SQ in MetS (-) group. Poor PSQoL was correlated with anxiety, depression, poor BIQoL, poor overal SQ and impairing in three sleep-subcomponents in MetS (+) group, whereas no correlation was found between these parameters and PSQoL in MetS(-) group.
Conclusions: MetS is seen at high-rate in patients with long-term PS. PS-severity is especially correlated with anxiety, impaired-flourishing, and impaired-SQ in PS-patients with Mets (+). PSQoL appear to be correlated with depression, anxiety, distorted-BI and impaired SQ in these patients. It should be kept in mind that neuropsychological factors may facilitate the development of dysmetabolic events in PS-patients, by impairing PSQoL.
Expanding the genotypic and phenotypic spectrum of the SPTBN4 gene mutation: A new variant and dysmorphology
Authors: Günay Çağatay , Onay Hüseyin , Bademkıran Fikret , Hız Kurul Semra , Yiş Uluç
Published: September 2023

Congenital hypotonia and neuropathy caused by SPTBN4 mutation are the core findings of a newly defined rare syndrome: Neurodevelopmental disorder with hypotonia, neuropathy, and deafness. Although hearing loss secondary to auditory neuropathy, dysmorphic findings, and epilepsy are distinctive features, they are not present in every patient, leading to a wide range of phenotypic spectrum. We report here a male patient with the SPTBN4 gene mutation presenting with core symptoms but not hearing loss and epilepsy. There were also previously unreported dysmorphic findings such as prominent eyebrows, bilateral constant esotropia, microphthalmia, bitemporal narrowing, low hairline, low-set ears, broad nasal bridge, bulbous nose, anteverted nares, and high-arched palate, broadening the phenotypic spectrum even further. In conclusion, both genetic background and phenotypic features of the SPTBN4 mutations were expanded in our report. After exclusion of spinal muscular atrophy in patients with congenital hypotonia and areflexia, the SPTBN4 mutations should be considered.
Use of repetitive transcranial magnetic stimulation and 2D ultrasound in resection of low-grade glioma at motor strip area in resource limited setting
Authors: Sahoo Sushanta , Kar Sujita , Srivastava Chhitij
Published: September 2023

Eloquent area glioma surgery is technically demanding. Identification and preservation of the functional area determines the long term outcome. Here we discuss the use of transcranial magnetic stimulation (TMS) and 2D ultrasound (2DUSG) in resection of low grade glioma (LGG) located at motor strip area. In five patients where the LGG was located close to motor area were evaluated with TMS in the preoperative period and the functional area is marked. This information is used for planning the craniotomy. A 2DUSG is used to detect the margin of resection. Complete excision was feasible in two and partial resection in three without any added deficit. TMS is an useful tool for localizing motor area in the pre operative period for patients with tumor located close to the motor area. Additionally 2DUSG provides real time imaging to safeguard the eloquent brain area. Combination of these two offers low cost, easily available method for resecting eloquent area brain tumors in resource limited areas.
The effect of discharge training and telephone counseling service on patients’ functional status and caregiver burden after stroke: A randomized controlled trial
Authors: BİTEK Deniz Ezgi , EROL Özgül
Published: September 2023

Objective: This study aimed to determine the effect of discharge training and telephone counseling service on patients’ functional status and caregiver burden after stroke.
Methods: This study was conducted as a randomized controlled trial in 69 stroke patients and their caregivers. Discharge training and telephone counseling were given to the caregivers in the intervention group. Caregivers also received telephone counseling by calling researcher when needed. Information form for participants, Modified Rankin Scale, Barthel Index and The Zarit Caregiver Burden Scale were used for data collection. Pre-tests were applied to the intervention and control groups before discharge. Three months after discharge post-tests were performed for the two groups.
Results: Three months after discharge, caregivers’ burden was significantly lower in the intervention group compared to the control group. The mean Modified Rankin Scale score of the patients in the intervention group was significantly lower than the control group three months after discharge. Although the mean Barthel Index score of the patients in the intervention group was statistically significant higher than before discharge, but the difference between the groups was not statistically significant.
Conclusion: Discharge training and telephone counseling provided to the caregivers of stroke patients reduced the caregiver burden and had a positive effect on the improvement of the functional status of the patients.
The role of red blood cell distribution width to platelet ratio in predicting hemorrhagic transformation after mechanical thrombectomy therapy in acute ischemic stroke patients
Authors: Tao Weiwei , Yu Dan , Wu Gang , Wang Wanfen , Hu Xiaofei
Published: September 2023

Objective: Hemorrhagic transformation (HT) is common complication after mechanical thrombectory (MT) for acute ischemic stroke (AIS). To our knowledge, there has been no study on the correlation between baseline red blood cell distribution width (RDW) to platelet ratio (RPR) and HT after MT.
Methods: This study recruited 126 AIS patients with anterior or posterior circulation large-vessel occlusion who underwent MT therapy at the Department of Neurology, Taizhou Hospital, Zhejiang province between September 2019 and April 2021. Patients were divided into two groups: patients with HT and those without HT (wHT), and their laboratory and clinical data were compared.
Results: We found no significant differences in sex, age, alcohol consumption, diabetes mellitus, atrial fibrillation, systolic blood pressure, diastolic blood pressure, triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, serum creatinine, blood urea nitrogen, fibrinogen, neutrophil count, lymphocyte count, neutrophil-to-lymphocyte ratio (NLR), National Institutes of Health Stroke Scale (NIHSS) score, Alberta Stroke Program Early Computed Tomography Score (ASPECTS), whether intravenous thrombolysis was accepted, and TOAST classification between the two groups. Compared with patients without HT, we found that the admission blood glucose, RDW and RPR levels were higher in patients with HT after MT in AIS patients, multivariate logistic regression analysis revealed that baseline RPR (odds ratio (OR), 1.290; 95% CI, 1.062–1.567; P=0.010) and glucose level (OR, 1.177; 95% CI, 1.013–1.369; P=0.034) are independent predictors for HT after MT.
Conclusion: Higher baseline RPR and higher admission blood glucose levels might be related to HT in AIS patients who received MT therapy.
Análisis descriptivo de las materias de inglés en los grados de Educación Infantil en las universidades españolas
Authors: Garcés-Manzanera Aitor
Published: September 2023

Introducción: este estudio analiza cómo se enseña el inglés en las universidades españolas en el ámbito de la educación infantil. El objetivo principal es detectar tendencias y evaluar si se están considerando las capacidades profesionales y académicas necesarias para la formación lingüístico-pedagógica. Metodología: se tomó una muestra dirigida de 10 universidades españolas públicas, donde se analizaron sus guías docentes usando un instrumento ad hoc basado en estudios previos. Se evaluaron tanto materias obligatorias como optativas en las que la lengua extranjera (inglés) fuera el foco principal. Resultados: los resultados muestran un balance entre el contenido específico de educación y lengua, con variaciones entre los diferentes ítems analizados. Aunque se aborda la enseñanza del inglés desde una perspectiva generalista, hay una presencia significativa del contexto específico educativo. Conclusiones: este estudio ofrece una visión detallada sobre cómo se enseña el inglés en las universidades españolas en el ámbito de la educación infantil. Los resultados sugieren que existe una preocupación por integrar la formación lingüística con la pedagógica, pero aún hay margen para mejorar y considerar las capacidades profesionales y académicas necesarias para la formación lingüístico-pedagógica. En resumen, se necesita una mayor atención a la formación específica en el ámbito de la educación infantil para mejorar la calidad de la enseñanza del inglés en las universidades españolas.
INVESTIGATING THE ROLE OF ANIMAL BEHAVIOUR IN THE TRANSMISSION AND SPREAD OF ZOONOTIC DISEASES
Authors: BATOOL A , ARIF R , SADDIQUE H , KOMAL M , FATIMA U , ZAINAB K , HABIB MS , KHAN A , CHAUDHRY AA
Published: September 2023

Emerging infectious diseases (EIDs) have significant public health and economic impacts and are frequently increasing. The study's main objective is to investigate animal behavior's role in the transmission and spread of zoonotic diseases. This analytical study was conducted at Ali Veterinary Hospital Lahore from August 2022 to January 2023. A crucial step in this study was the selection of study sites, which represented diverse ecological and geographical regions where zoonotic diseases were known to be prevalent. These sites were chosen to encompass a wide range of zoonotic disease types and to reflect areas where wildlife, domesticated animals, and humans frequently interacted. The selection process ensured a robust and representative dataset for analysis. A total of 12 study sites were selected across diverse geographical regions, encompassing ecosystems ranging from temperate forests to arid savannas. Behavioral data were collected from 5 species of animals, including raccoons, bats, and deer, known to be potential hosts or reservoirs for zoonotic diseases. Observations of animal behavior revealed several notable patterns. For instance, nocturnal animals such as bats exhibited communal roosting behavior in 80% of observations, while migratory birds displayed seasonal movement patterns covering an average distance of 500 miles. It is concluded that this study underscores the pivotal role of animal behavior in zoonotic disease transmission and highlights the need for a multidisciplinary approach to address this complex issue.
THE RISK OF OCCUPATIONAL CONTACT DERMATITIS IN COVID-19 ISOLATION WARD SETTING
Authors: MUSHTAQ I , JAMIL A , AWAN FNK , MALIK A , QAMBER JH , AKHTAR MS
Published: September 2023

Occupational contact dermatitis (OCD) is a prevalent skin condition affecting healthcare workers, particularly those in high-risk environments such as COVID-19 isolation wards. This study aims to summarize the findings of a study conducted on patients to explore the risk factors associated with OCD development among healthcare professionals in COVID-19 isolation ward settings. This prospective observational study aimed to assess the risk of occupational contact dermatitis (OCD) among healthcare professionals working in the COVID-19 isolation ward setting. The study was conducted at Chaudhary Mohammad Akram Hospital for six months, from November 2021 to April 2022. Data was collected from 150 participants of both genders. The participants ranged from 22 to 55 years, with a mean age of 32.5 ± 6.8 years. The study population consisted of 55% females and 45% males. The occupation distribution included doctors (40%), nurses (50%), and support staff (10%). Clinical evaluations revealed that 38 healthcare professionals (25.3%) exhibited signs consistent with occupational contact dermatitis. Among them, 18 participants (47.4%) were diagnosed with irritant contact dermatitis (ICD), while 20 participants (52.6%) showed signs indicative of allergic contact dermatitis (ACD). It is concluded that this study highlights the significant prevalence of occupational contact dermatitis among healthcare professionals in COVID-19 isolation wards. Prolonged PPE usage and frequent hand hygiene practices contribute to skin irritation.
Modelling Child Survival at Birth Data Using Logistic Regression Model: A Case Study of Yobe State Specialist Hospital Damaturu, Nigeria
Authors: Madaki Umar , Ahmad Muhammad , BABA ISHAQ
Published: September 2023

This research examines factors influencing the survival of child at birth in Yobe State Specialist Hospital using a well-known logistics regression model. A total of 150 data points were collected through transcription from the maternity record of the Hospital to test significant factors that affect survival of child at birth.  Analysis of logistic regression model was applied to the data using the Generalized Linear Model (GLM) package in R programming software. The results indicate that Type of delivery and weight at birth have the most significant influence on the probability of child survival at birth at 0.001 level of significance. Correlation analysis results show that all the five variables (age, parity, apgar, birth weight, and type of delivery) have a weak relationship, which implies that there is no multicollinearity in the data. Therefore, these results may help policy makers and health personnel to educate pregnant women on the effect of overweight baby at birth to reduce the incidence of deaths at birth. This study recommend that pregnant women should be educated about the effect of baby weight in a worm as that may increases the chance of caesarean section which in turn may affect the likelihood of child survival at birth.   Further studies are suggested to consider factors like educational level, income of level of the family, antennal status, and blood pressure.  A more advance community-based survey is recommended since not pregnant women attain formal health care facilities for antennal and postnatal services, which may expose more factors that influence child survival at birth.
Efektivitas Iklan di Youtube dan Komunitas Merek serta pengaruhnya terhadap Keputusan Pembelian
Authors: Murtini Mukti , Listyawati Indri Hastuti , Prasetyanto Wahyu Eko
Published: September 2023

Keberadaan media sosial di internet memungkinkan terbentuknya komunitas merek virtual, baik dalam hubungan transaksional maupun relasional. Komunitas merek ini berpotensi memengaruhi niat beli konsumen, seperti yang ditunjukkan beberapa penelitian nyata. Penelitian ini mengkaji hubungan antara efektivitas periklanan dan komunitas merek dalam keputusan pembelian berdasarkan iklan YouTube. Selain itu, penelitian ini juga berhipotesis bahwa komunitas merek memoderasi hubungan antara efektivitas periklanan dan keputusan pembelian. YouTube dipilih karena merupakan sumber sosial yang memungkinkan penayangan iklan dalam format visual. Keputusan pembelian diukur secara tidak langsung oleh memori iklan ("suka" dan "tidak suka" iklan). Analisis dilakukan dengan menggunakan metode regresi linier terhadap 59 sampel video dari merek-merek besar Indonesia. Hasil analisis menunjukkan hubungan yang signifikan antara efektivitas periklanan dan komunitas merek dalam hal niat beli. Namun, komunitas merek berpengaruh negatif terhadap hubungan antara efektivitas iklan dan niat beli. Teori logika dominasi konsumen ditawarkan sebagai penjelasan atas terjadinya hubungan negatif tersebut. 
Kata kunci: efektivitas iklan, keputusan pembelian, komunitas merek, Youtube
Allelopathic compounds in Vitex negundo
Authors: Sasikumar K. , Paramathma M. , Parthiban K.
Published: September 2023

Investigations carried out to identify the allelopathic compounds in the leaf leachates of Vitex negundo using paper and gas chromatography revealed the presence of r-coumaric, r-hydroxybenzoic, ferulic, vanillic and syringic acids besides catechol. The allelopathic influence of leachate was tested by petriplate bioassay and crops of blackgram, cowpea, greengram, horsegram and pigeonpea in pot culture under nursery conditions. Crop growth, root length, shoot length, nodule dry weight and nitrogenase activity were depressed in all test crops. Maximum reductions in growth, root length and shoot length were obtained with cowpea; nodule dry weight with greengram and nitrogenase activity with horsegram.
Is There A Genetic Predisposition for Transitional Cell Carcinoma of the Bladder at a Young Age?
Authors: TAŞ Selim , EREN Ali Erhan , ÖLÇÜCÜ Mahmut Taha , PAKSOY Barış , İSLAMOĞLU Ekrem , BOĞA Mehmet Salih
Published: September 2023

Objective: The aim of this study is to determine whether there is a genetic predisposition in young patients
with transitional cell carcinoma (TCC) of the bladder.
Material And Methods: Data were collected from a total of 652 patients who underwent transurethral
resection of bladder tumor (TUR-BT) between January 2010 and January 2021. Seven patients under the age
of 40, non-smokers, and without occupational predisposing factors to urinary tract TCC were included in the
study. Age, body mass index (BMI), sex, occupation, and five-year follow-up were collected retrospectively.
A total of 403 cancer-related genes were analyzed from the patients’ blood samples. The Clinical Exome
Sequencing test was used to identify genetic mutations.
Results: Six of the patients were male and one patient was female. The mean age and BMI were 31.42 ± 2.12
(22-39) years and 21.72 ± 33.14 (22-27.7) kg/m2, respectively. None of the patients had a first-degree relative
with urinary tract TCC. Of all the patients, only one patient had a deletion of exons 1 to 17 in the breakpoint
cluster region gene.
Conclusion: Genetic predisposing factors in young bladder TCC have not been clearly identified. Although
our study included a limited number of patients, our results showed no genetic predisposition in young
patients with bladder TCC without family history of bladder cancer. To evaluate the exact relationship,
prospective randomised controlled trials with larger numbers of patients are needed.
Efficacy of Biphasic Fluid Therapy in Robot-Assisted Kidney Transplantation
Authors: SAYGI EMİR Nalan
Published: September 2023

Objective: Perioperative fluid treatment is among the factors affecting transplant kidney function. In this
study, the efficacy of biphasic fluid treatment on per-operative patient stabilization and allograft kidney
functions were evaluated.
Material and Methods: Data of 65 robotic living releated donor kidney transplantation performed between
2015-2017 were retrospectively analyzed (16/04/2018, Protocol no 2018-07-13). The patients were divided as
preemptive (Group Preemptif: GP, n=27) and non-preemptive group (Group Non-Preemptif: GNP, n=38).
Biphasic fluid treatment was used in all cases (Phase 1 = before-vascular anastomosis 1-3 ml/kg/h and phase
2 = after-vascular anastomosis 10-12 ml/kg/h, respectively). Hemodynamic and biochemical status of the
patients, early and late allograft kidney function were evaluated. Datas were statistically compared within
and between the groups.
Results: Hemodynamic/metabolic stability and diuresis were achieved after vascular anastomosis in all
patients. There was no difference in the total amount of iv fluid given between the groups, except that the
amount of fluid given in phase 1 was significantly less in GP (p<0.05). Pre-operative blood pH and HCO3
values were lower, Na+ and Cl- values were higher in GP(p<0.05). No difference was found in K+ and Ca+2
values at all times and pH values after extubation in both groups. Pre-operative blood urea and creatinine
levels were significantly higher in GP (p<0.05) but all decreased to normal on postoperative 1 and 7 days. In
long-term follow-up, both groups had similar mortality and rejection rates.
Conclusion: Our results support that biphasic fluid treatment is effective to achieve hemodynamic/
metabolic stability and allograft kidney functions in robotic living releated kidney transplantation patients.
ANALISIS KESELAMATAN PELAYARAN KAPAL PENUMPANG KM THALIA RUTE PARE-PARE-NUNUKAN
Authors: Raising Rahman
Published: September 2023

Di Indonesia, keselamatan maritim tetap menjadi salah satu isu terpenting karena kecelakaan pelayaran terus terjadi.  Kapal merupakan suatu alat angkut transportasi yang sangat vital untuk mengangkut barang dan penumpang, Adapun yang dimaksud dengan keselamatan pelayaran adalah keadaan kapal yang memenuhi persyaratan, baik material, konstruksi, bangunan, permesinan, perlistrikan, stabilitas, tata susunan serta perlengkapan kapal.

Tujuan dari penelitian ini untuk mengindentifikasi peralatan keselamatan kerja beserta jumlah yang dimiliki dan disesuaikan dengan Permen Perhubungan Nomor 61 Tahun 20019 tentang kelaiklautan kapal penumpang kecepatan tinggi berbendera Indonesia. Untuk menjamin keselamatan kapal, diperlukan proses pemeliharaan atau maintenance pada seluruh alat keselamatan kapal. Oleh karena itu, penelitian ini bertujuan untuk analisis keselamatan pelayaran kapal penumpang KM Thalia rute Pare-pare-Nunukan.

Pendekatan yang digunakan dalam penelitian ini adalah pendekatan deskriptif kuantitatif. Penelitian deskriptif adalah penelitian yang menggambarkan keadaan obyek penelitian untuk mengungkapkan masalah atau fakta yang ada secara sistimatis, factual, akurat, serta sifatsifat dan hubungan antar fenomena yang diselidiki. Sedangkan analisis kuantitatif digunakan untuk mengukur atau menguji data sehingga menghasilkan jawaban dari identifikasi masalah.

Keselamatan jiwa di laut tidak bergantung dari kapal, awak kapal maupun peralatannya, Sumber daya manusia (SDM) awak kapal terutama nakhoda memiliki peran penting dalam keselamatan dan keamanan pelayaran. Keberhasilan pengangkutan atau pelayaran melalui laut tidak terlepas dari peranan nakhoda yang memiliki pengetahuan, keterampilan dan rasa tanggung jawab yang besar serta menyeluruh ketika menjalankan tugasnya. Nakhoda merupakan salah seorang dari awak kapal yang menjadi pimpinan tertinggi di kapal yang memiliki wewenang dan tanggung jawab tertentu, secara otomatis nakhoda mengemban tanggung jawab yang berat atas kapal, awak kapal, muatan dan atau penumpang dalam penyelenggaraan pengangkutan, Kesiapan peralatan-peralatan tersebut untuk digunakan sewaktu-waktu dan bagaimana pemeliharaan alat-alat keselamatan tersebut dengan tepat, khususnya dalam keadaan darurat. Diantaranya Sekoci penolong (life boat ), Rakit penolong (Liferaft), Rompi Penolong (Life Jacket). Seluruh crew kapal melaksanakan tugas dengan baik sehingga alat keselamatan siap digunakan apabila terjadi keadaan bahaya
ANALISIS EVALUASI DIRI DENGAN KINERJA KARYAWAN PADA MANAJEMEN GUDANG LOGISTIK PT. PULAU SEROJA JAYA BANJARMASIN
Authors: Kamsariaty Kamsariaty , Juhrani Juhrani
Published: September 2023

PT.PULAU  SEROJA JAYA  Banjarmasin, perusahaan ini merupakan penyedia jasa logistik yang memberikan pelayanan jasa pergudangan. Jasa logistik terdiri atas pelayanan pergudangan,pendistribusian dan transportasi. Gudang memiliki peran yang sangat penting dalam sebuah perusahaan.Secara operasional, penggudangan merupakan serangkaian kegiatan pengursan dalam penyimpanan logistik mulai dari kegiatan penerimaan, pencatatan, pemasukan, penyimpanan, pengaturan, pembukuan, pemeliharaan, pengeluaran, dan pendistribusian sampai dengan kegiatan pertanggungjawaban pengelolaan gudang (pembuatan laporan-laporan) dengan tujuan mendukung kontiunitas unit kerja, sekaligus efektivitas dan efisiensi organisasi secara keseluruhan. Metode penelitian yang digunakan Penelitian kualitatif deskriptif. Teknik pengolahan data berupa observasi, wawancara,dokumentasi dan library kepustakaan.

Kesimpulan dalam penelitian ini meliputi Penilaian  evaluasi diri dan kinerja  karyawan gudang adalah kegiatan manajer atau atasan untuk mengevaluasi perilaku prestasi kerja karyawan serta menetapkan kebijakan selanjutnya, penilaian Kinerja termasuk kedalam sumber daya manusia, sumber daya manusia yang komperatif adalah kunci kesuksesan perusahaan. Dengan dilakukannya penilaian kinerja terhadapat karyawan akan membuat karyawan akan selalu berusaha berbuat semaksimal mungkin dalam setiap kegiatan yang diberikan oleh perusahaan atau pimpinan dan manajer juga mudah melakukan kegiatan perusahaan dalam bidang menaikan jabatan dari karyawan maupun melihat kinerja karyawan yang tidak maksimal. Selain itu tujuan lain dari perusahaan melakukan evalausi diri dan  Penilaian Kinerja karyawan gudang adalah upaya perusahaan dalam melakukan pembinaan SDM untuk meningkatkan kinerja dan kompetensi karyawan yang bersangkutan. Penilaian Kinerja bukanlah suatu hukuman melainkan bentuk perhatian pimpinan terhadap karyawan.

Saran  Bagi PT.PULAU  SEROJA JAYA  Banjarmasin Agar para karyawan bagian pergudangan lebih meningkatkan kemampuannya dalam bekerja, baik dalam artian peningkatan kualitas, kuantitas serta waktu dalam melaksanakan pekerjaan yang dibebankan. Maka karyawan dapat mengikuti  pelatihan tentang manajemen pergudangan untuk meningkatan keahlian dan keterampilan karyawan dalam melakukan pekerjaannya