bluuebunny/crossref_metadata_2025 huggingface dataset:
ÖN İŞLEMSİZ DONMUŞ DEPOLANAN (-22± 1 ºC) HAMSİ (Engraulis encrasicolus, Linnaeus 1758) VE PALAMUT (Sarda sarda, Bloch 1793) BALIKLARININ DUYUSAL, BESİNSEL, KİMYASAL VE MİKROBİYOLOJİK ÖZELLİKLERİ
Authors: ÇORAPCI Bengunur
Published: December 2018

Bu çalışmanın amacı, hamsi (Engraulis encrasicolus, Linnaeus
1758) ve palamut (Sarda sarda, Bloch 1793) balıklarının ön
işlemsiz donmuş depolama süresince duyusal, besinsel, kimyasal ve
mikrobiyolojik özelliklerinin belirlenmesidir. Palamut balıkları buzdolabı
poşetlerine konularak, hamsi balıkları ise polistiren tabaklara konularak ve
ardından streç film ile kaplanarak paketlenmiştir. Her iki grup da -22±1ºC’de
12 ay depolanmıştır. Besin kompozisyonu, pH, su aktivitesi, TVB-N, TBA ve
mikrobiyolojik analizler taze balıkta (0. gün) ve dondurulmuş balıklarda (12 ay
sonu), peroksit analizi, aminoasit ve yağ asitleri analizleri dondurulmuş
balıklarda (12 ay sonu) ve duyusal analizler ise 0. gün, 6. ay ve 12 ay sonunda
gerçekleştirilmiştir. Sonuç olarak; ön işlemsiz olarak buzdolabı poşetlerinde
depolanan palamut balıklarının -22± 1ºC’de 12 ay sonunda dahi duyusal açıdan
tüketilebilirlik özelliklerini koruduğu, polistiren tabaklara konularak streç
film ile paketlenen hamsi balıklarının ise 6 ayın sonunda duyusal olarak
bozulduğu söylenebilir.
ENHIDE telehealth support for 148 disengaged young adults with type 1 diabetes: a pilot study – rationale and study design
Authors: Winocour Peter H , Solomon Andrew , Currie Anne , Hardy Dawn , Moore-Haines Karen , Renshaw Claire
Published: December 2018

Disengaged young adults with type 1 diabetes are vulnerable to poor health outcomes. Potentially 20% of those aged 16–30 years could be included in this category. East and North Herts Clinical Commissioning Group (CCG) commissioned the East and North Herts Institute of Diabetes and Endocrinology (ENHIDE) to pilot an innovative model of care in August 2016. Young adults aged 16–30 were offered an alternative model of tailored care, with access to a young adult support worker and specialist nurse. Inclusion in the project was based on fulfilling at least one of the following criteria:Acute admission with diabetic ketoacidosis or hypoglycaemiaNon-attendance for retinal screeningNon-attendance at clinics on at least two consecutive occasionsPersistent HbA1c levels >75 mmol/molNon-attendance for routine laboratory measures of glycaemia and renal functionMultidisciplinary team review stating need for more flexible careWe invited 148 young adults to participate in the project. Of these, 118 have been recruited after the initial contact, markedly exceeding the 10% take-up rate set by the CCG. The project will evaluate changes in emergency admissions, attendance for routine biochemical tests and retinal screening, changes in glycaemic control and quality of life measures at 6 and 12 months after entry to the project
Ekvilibrij korporativne marke: analiza identiteta
Authors: Jukić Dinko
Published: December 2018

U radu se predstavljaju i analiziraju suvremeni modeli korporativne marke, konstrukti osobnosti marke kao i model C2ITE. Ekvilibrij korporativne marke čini integriran model različitih teorijskih pristupa fenomena marke. Primarni model preuzima se kao heksagonski identitet marke jer je ujedno i ishodišni konstrukt koji ujedinjuje izvedene modele. Korporativna marka je kauzalna i ovisi o zajedničkoj komunikaciji sa svim C2ITE značajkama. Ishodište korporativne marke je korporativni identitet koji je prikazan i tumačen modelom testa ACID. Korporativni identitet je esencijalan iz više razloga: omogućuje daljnje stvaranje korporativne marke, imidža i drugih konstrukata, ali i zbog strateške dimenzije pozicioniranja marke u svijesti potrošača. Konstrukti osobnosti marke potvrđuju dimenzije modela CBBE. Ekvilibrij korporativne marke predložen je raščlambom identiteta, imidža i osobnosti. Korporativna marka mora imati sposobnost brzog reagiranja na tržišne promjene kao i razvijen suradnički pristup prema svim sudionicima.
The utility of transthoracic echocardiographic measures of right ventricular systolic function in a lung resection cohort
Authors: McCall Philip , Soosay Alvin , Kinsella John , Sonecki Piotr , Shelley Ben
Published: December 2018

Right ventricular (RV) dysfunction occurs following lung resection and is associated with post-operative complications and long-term functional morbidity. Accurate peri-operative assessment of RV function would have utility in this population. The difficulties of transthoracic echocardiographic (TTE) assessment of RV function may be compounded following lung resection surgery, and no parameters have been validated in this patient group. This study compares conventional TTE methods for assessing RV systolic function to a reference method in a lung resection population. Right ventricular index of myocardial performance (RIMP), fractional area change (FAC), tricuspid annular plane systolic excursion (TAPSE) and S′ wave velocity at the tricuspid annulus (S′), along with speckle tracked global and free wall longitudinal strain (RV-GPLS and RV-FWPLS respectively) are compared with RV ejection fraction obtained by cardiovascular magnetic resonance (RVEFCMR). Twenty-seven patients undergoing lung resection underwent contemporaneous CMR and TTE imaging; pre-operatively, on post-operative day two and at 2 months. Ability of each of the parameters to predict RV dysfunction (RVEFCMR <45%) was assessed using the area under the receiver operating characteristic curve (AUROCC). RIMP, FAC and S′ demonstrated no predictive value for poor RV function (AUROCC <0.61, P > 0.05). TAPSE performed marginally better with an AUROCC of 0.65 (P = 0.04). RV-GPLS and RV-FWPLS demonstrated good predictive ability with AUROCC’s of 0.74 and 0.76 respectively (P < 0.01 for both). This study demonstrates that the conventional TTE parameters of RV systolic function are inadequate following lung resection. Longitudinal strain performs better and offers some ability to determine poor RV function in this challenging population.
Towards Rational Utilization of Indigenous Plant Resources
Authors: Khider Tarig Osman , Hubbe Martin A.
Published: December 2018

The world has huge floral diversity, whereas there often is poor and irrational utilization, especially of indigenous plants and residues from agricultural processes. Trees, shrubs, and herbs can have multiple uses at different levels as medicines and sources of lignocellulosic materials. A fuller and more rational utilization is needed, with interaction of international and national communities, to raise the awareness of local people, governments, and industrial entrepreneurs of the floral wealth that is waiting to be utilized more effectively.
Contribution of Face and Core Layers to Lateral Load Resistance of Single-Shear Metal-to-Particleboard Single-Screw Connections
Authors: Wang Yan , Zhang Jilei
Published: December 2018

The lateral load-slip behavior of a single-shear metal-to-particleboard single-screw connection (SMPSC) was investigated. The connection consisted of a layered particleboard main member fastened to a metal plate as a side member using a 4.8-mm diameter sheet metal screw. A mechanics-based approach was used to evaluate critical factors on the lateral load resistance performance of SMPSCs. Experimental results indicated that ultimate screw-bearing strengths in face and core layers of evaluated particleboard materials were 100.0 and 29.9 MPa, respectively. This significant difference of screw-bearing strength in material layers significantly affected the lateral resistance load capacity of SMPSCs. The proposed mechanical models considering material layer effects on screw-bearing strengths were verified experimentally as a valid means for deriving estimation equations of lateral resistance loads of SMPSCs evaluated in this study.
Hacia una definición y caracterización de las guías de forasteros en América hispana, 1761-1893
Authors: Cuéllar Wills Lina
Published: December 2018

Este artículo propone una definición y caracterización de las guías de forasteros publicadas en América hispana desde la segunda mitad del siglo xviii hasta finales del xix, por medio de una clasificación tripartita de dichos impresos: el modelo imperial, el modelo letrado y el modelo comercial. Esta forma de organizar tales guías permite entenderlas como parte del proceso de formación y consolidación de las formas impresas en el continente, en un contexto social, cultural y político que duró aproximadamente 120 años. El enfoque principal de este estudio es la historia cultural y, más específicamente, la historia de las formas impresas.
“Un hombre bajado inmediatamente del cielo”: la potencia regia en la historia neogranadina
Authors: Vanegas Useche Isidro
Published: December 2018

Este artículo indaga por el lugar del rey en la sociedad de finales del Virreinato de la Nueva Granada y del periodo revolucionario, en contravía de la idea fuertemente implantada a partir de la Revolución Neogranadina según la cual aquella sociedad se había forjado al margen del poder regio. En primer lugar se muestra la importancia del rey en la historia neogranadina y se intenta comprender por qué le había sido negada su centralidad; en segundo lugar se estudia el significado del monarca y la naturaleza de su poder antes de la revolución de la década de 1810; y, en tercer lugar, se observa la manera como fue transformada la relación con el rey a partir del acontecimiento revolucionario.
Prácticas clientelistas en la política del estado de Santander durante la etapa federal colombiana, 1857-1886
Authors: Ariza Ariza Nectalí
Published: December 2018

En este artículo se observan las prácticas clientelistas en Santander durante el periodo federal colombiano, con el objetivo de comprender la reproducción del poder político en una etapa particularmente inestable. Metodológicamente, se analiza la estructura del estado, los recursos públicos disponibles y las prácticas clientelistas, cuya huella quedó en los nombramientos, los contratos de remates fiscales y la correspondencia intercambiada, principalmente durante el gobierno del caudillo Solón Wilches, el actor político que más tiempo ocupó el poder del estado. De los resultados, se destaca que el clientelismo se facilitaba por la precariedad institucional, el caudillismo militar y la pobreza.
A Rimanóczy építészdinasztia története (III. rész)
Authors: Rimanóczy Jenő , Ferkai András
Published: December 2018

A sorozat előző két része az építészdinasztia nagyváradi ágáról, illetve a Budapesten megtelepedett hadmérnök, Rimanóczy Árpád fiáról, idősebb Rimanóczy Gyuláról szólt. Gyula mindkét fia építész lett, pályájukat apjuk egyengette, és egy sor tervpályázaton közösen is indultak. Egyikük sem került azonban az apa műtermébe, sőt a Középülettervező Vállalatot is elkerülték. Ifjabb Gyula a Budapesti Városépítési Tervező Vállalatnál, Jenő pedig az Ipartervben dolgozott hosszú időn át, majd az Általános Épülettervező Vállalat főmérnöke lett. A tanulmány célja a két építész életpályájának rövid felvázolása és munkáik lehető legteljesebb bemutatása, beleértve a meg nem valósult tervek és pályázati tervek egyébként nehezen feltárható hosszú sorát. Ezzel egyben szeretnénk a hatvanas-hetvenes évek talán kevésbé ismert, vagy feledésbe merült alkotásaira is felhívni a figyelmet.
Liver bud transplantation in rats
Authors: Kobayashi Eiji , Enosawa Shin
Published: December 2018

Introduction: Research has made progress in organ fabrication
using an extracellular matrix, cell sheets, or organoids. Human liver tissue has
been constructed using a 3-dimensional (3D) bioprinter and showed evidence that
an in vitro generated liver bud was reformed in a rodent liver
model. This study describes the stages of development of rat fetal organs and
liver structure and reviews recent progress in liver organoid transplantation.
Methods: The authors developed the procedures for creating
a transected plane for use in experimental microsurgery in rats. A liver lobe
was fixed vertically with gauze and it was ligated with 6-0 silk suture in the
cut line; the parenchyma was cut, and major vessels were ligated to create the
transected plane. The ligated tissue was carefully resected. Hemostasis was not
required and hepatic components remained on the transected plane. The plane was
covered by omentum. Results: Using this model, we transplanted
fetal liver or a 3D bioprinted liver organoid. This microsurgical method enabled
creation of an intact liver parenchyma plane. No bleeding was observed. The
transplanted liver components successfully engrafted on the liver.
Conclusion: This method may provide an essential
environment for growing liver using portal and arterial blood flow.
First record of the Conchos Shiner Cyprinella panarcys (Hubbs & Miller, 1978) from the mainstem of the Rio Grande along the USA–Mexico border
Authors: Pinion Amanda K. , George Stephanie D. , Perkin Joshuah S. , Conway Kevin W.
Published: December 2018

Cyprinella panarcys is considered to be endemic to the upper Río Conchos drainage of Mexico. A single individual of C. panarcys was collected from the Rio Grande along the USA–Mexico international border (Presidio Co., Texas) in April 2018. This is the first record of C. panarcys from outside of the Río Conchos and the first record from the USA. A brief description of the external morphology of the individual collected is provided along with an updated distribution map for the species.
Effekt eines Insektenprotein-basierten Futters auf die Symptomatik von futtermittelallergischen Hunden
Authors: Klinger Christoph , Gedon Natalie , Udraite Laura , Hiltenkamp Katja , Mueller Ralf , Böhm Teresa
Published: December 2018

Gegenstand und Ziel: Essbare Insekten (wie Mehlwürmer, Heuschrecken und Grillen) enthalten hohe Mengen an Energie, Protein, essenziellen Fettsäuren sowie Mengen- und Spurenelementen und stellen eine qualitativ hochwertige Nahrungsquelle dar. Sie sind als neuartige Proteinquellen für Futtermittelallergiker interessant und können auch in ökologischer und ethischer Hinsicht sinnvoll sein. Ziel dieser Fallserie war, die Wirkung eines neuen kommerziell erhältlichen Insektenprotein-basierten Trockenfutters auf die Symptomatik dieser Hunde mittels Canine Atopic Dermatitis Lesion Index (CADLI), Pruritus Visual Analogue Scale (PVAS) und Fellqualitätsscore zu evaluieren. Material und Methoden: In diese Studie wurden 20 Hunde mit atopischer Dermatitis aufgrund einer diagnostizierten Futtermittelunverträglichkeit eingeschlossen. Die Hunde erhielten 2 Wochen lang ausschließlich dieses Futter. Ergebnisse: Die Studie beendeten 15 der 20 Hunde. Bei 12 dieser Tiere wurde eine Verbesserung der Läsionen festgestellt, zwei entwickelten eine geringgradige Verschlechterung der Hautveränderungen und ein Patient präsentierte sich klinisch unverändert. Der Juckreiz verringerte sich bei acht Patienten, blieb bei vier Hunden unverändert und verstärkte sich bei drei Tieren (in zwei Fällen geringgradig um durchschnittlich 1,5 Juckreizscore-Punkte, bei einem Patienten dramatisch um 8 Juckreizscore-Punkte). Die bei 14 Hunden beurteilte Fellqualität verbesserte sich bei sechs Tieren und änderte sich nicht bei acht Hunden. Signifikante Unterschiede ergaben sich hinsichtlich der Verbesserung des Scores für die Hautläsionen (Wilcoxon- Test, p = 0,007) und der Fellqualität (Wilcoxon-Test, p = 0,01), nicht aber für den Juckreiz-Score (p = 0,53). Die Palatabilität des Futters war sehr gut. Außer bei einem Patienten galt dies auch für die Verträglichkeit. Schlussfolgerung und klinische Relevanz: Basierend auf diesen Ergebnissen ist das verwendete Insekten-basierte Trockenfutter eine interessante Fütterungsalternative bei Hunden mit Futtermittelunverträglichkeit.
Investigations on the prevalence of tortoise picorna-virus in captive tortoises in Germany
Authors: Funcke Svenja , Lierz Michael , Paries Susanne
Published: December 2018

Objective: Tortoise picornavirus (ToPV) has been speculated to play an important role in the frequently seen disease pattern of juvenile shell softening. This study aimed to determine ToPV prevalence among German tortoise collections. Material and methods: A total of 334 animals selected from 27 different collections were included. Seven species of four genera of the family Testudinidae (Testudo graeca, T. hermanni, T. marginata, T. horsfieldii, Centrochelys sulcata, Stigmochelys pardalis, Chelonoidis carbonarius) were sampled. The tortoises were clinically investigated and none of the adults showed any signs of shell softening. Seven hatchlings of a ToPV-positive T. graeca breeding pair showed retarded growth and a progressive shell weakness that resulted in death. Each animal was sampled by conjunctival, pharyngeal and cloacal swabs (990 swabs in total) and blood sampling (293 in total). All three swabs of one animal were pooled and tested by reverse transcriptase polymerase chain reaction (RT-PCR) for tortoise picornavirus RNA. Blood samples were investigated by virus neutralisation test (VNT) for specific anti ToPV antibodies. All titres equal to or higher than log2 = 2 were considered positive. Results: In total, 35 adult and 11 juvenile animals were tested positive for ToPV RNA. The serological investigation did detect specific antibodies against ToPV in 44 adult tortoises and one juvenile. In total, 76 animals were tested positive in either one of the investigations, 16 animals in both. The highest number of ToPV-positive animals was found for T. graeca, with a prevalence of 32 %. No specimens of C. carbonarius, C. sulcata, or S. pardalis were tested positive. Conclusion and clinical relevance: The results propose a predisposition in T. graeca, as well as a high prevalence of ToPV in T. graeca, whereas other species showed only single or no positive animals, but may function as virus carriers.
Cobalaminmangel bei Hund und Katze
Authors: Toresson Linda , Spillmann Thomas , Hanisch Franziska
Published: December 2018

Cobalamin ist ein Vitamin der B-Gruppe und als Kofaktor an Stoffwechselabläufen wie der Nukleinsäuresynthese, der Aminosäuresynthese und dem Zitratzyklus beteiligt. Da Säugetiere Cobalamin nicht selbst synthetisieren können, sind sie auf die Zufuhr über die Nahrung angewiesen. Die Resorption des Vitamins setzt bei Hund und Katze ein funktionales exokrines Pankreas voraus. Sie erstreckt sich über Magen und Duodenum bis hin zum Ileum und stellt einen äußerst komplexen Prozess dar. Somit kann eine Fülle gastrointestinaler Erkrankungen wie z. B. chronische Enteropathien, intestinales Lymphom oder exokrine Pankreasinsuffizienz zur Hypocobalaminämie führen. Ferner wurde bei einigen Hunderassen (Riesenschnauzer, Border Collie, Australian Shepherd und Beagle) ein primärer, hereditärer Cobalaminmangel (Imerslund-Gräsbeck-Syndrom) nachgewiesen. Zu den klinischen Sympto men einer Hypocobalaminämie zählen Inappetenz, Erbrechen, Diarrhö, Wachstumsstörungen und neuronale Defizite. Als labordiagnostische Veränderungen wurden nichtregenerative Anämie, Leukopenie, Hypoglykämie und Hyperammonämie beschrieben. Bei Verdacht auf einen Cobalaminmangel wird die Vitaminkonzentration bei Hund und Katze üblicherweise mittels Immunoassay im Blut gemessen. Da jedoch Blut- und Zellgehalt des Vitamins differieren können, ist die isolierte Cobalaminmessung in ihrer Aussagekraft limitiert. Die Therapie hängt in erster Linie von der Primärerkrankung ab und hat zum Ziel, die Ursache der Hypocobalaminämie zu beseitigen. Oftmals zeigt sich ein Behandlungserfolg der gastrointestinalen Erkrankung allerdings erst dann, wenn zusätzlich parenteral oder oral Cobalamin verabreicht wird. Bei Patienten mit Imerslund-Gräsbeck-Syndrom ist die regelmäßige und lebenslange Substitution essenziell.
Development of a fault simulator for soils under large vertical stress in a centrifuge
Authors: Takemura Jiro , Yao Chaofan , Kusakabe Osamu
Published: December 2018

Severe damages of structures observed in previous earthquakes due to faulting, especially reverse faulting with large discontinuous ground displacement under large earth pressure, have triggered studies on the failure mechanism of structures within fault zone. However, most of centrifuge tests focused on normal faulting due to the lack of apparatus simulating faulting under large earth pressure. In this research study, a fault simulator was designed and manufactured for centrifuge study of buried structures in soils over dip–slip fault, by which a large overburden pressure can be applied to the model soil. The design specifications are: (a) both normal and reverse faulting can be generated, (b) the simulator can function for reverse faulting condition under 50g with the surcharge pressure of 500 kPa, (c) the maximum offset of 30 mm with the dip angle of 60° can be achieved at the bottom of model soil, (d) the front face is transparent to observe the model ground during centrifuge tests. Using the fault simulator, a preliminary test series on buried pipe are conducted. The developed fault simulator shows very promising results with respect to rupture propagation, ground deformation and pipe behaviour.
A study on interface shear behaviour of soil nails from pullout and direct shear tests
Authors: Sharma Mahesh , Samanta Manojit , Sarkar Shantanu
Published: December 2018

Pullout and direct shear (DS) tests are most commonly used to measure the interface shear strength parameters required for soil–nail design. This paper investigates the effect of the surface roughness, and relative density (RD) and installation process on interface shear behaviour between the groutless soil nail and dry sand medium through laboratory pullout and DS interface tests. The test procedure and the interface shear results obtained from pullout tests are discussed and compared with that obtained from DS tests besides the existing literature. The study shows that in the pre-peak stage, the shear stress–displacement behaviour obtained from interface shear tests is similar to pullout tests and soil–soil DS tests. However, in the post-peak stage, the behaviour is similar to soil–soil DS tests but different from pullout tests. The interface shear stress behaviour of soil nail is significantly influenced by the installation process, RD of soil sample and surface roughness of the soil nail.
Legitimacy versus illegitimacy — transparency, integrity of financial markets and corporate governance: whither corruption?
Authors: A. ‘Arafa Mohamed
Published: December 2018

Ethics management globally is a swiftly growing reality with various countries placing substantial emphasis on anti-corruption initiatives. International organizations, including the United Nations (“UN”), Transparency International (“TI”), and the Organization for Economic Cooperation and Development (“OECD”) have created a number of anti-corruption creativities, for instance, the UN, promulgated an International Code of Conduct for Public Officials in 1996 . Moreover, the United Nations International Centre for Crime Prevention has established an Anti-Corruption Tool kit to ‘help U.N. Member States and the public to understand the insidious nature of corruption, the potential damaging effect it can have on the welfare of entire nations and suggest measures used successfully by other countries in their efforts to uncover and deter corruption and build integrity . In the same vein, TI, the only global non-governmental organization dedicated to battling corruption, seeks via education and information to dishearten corrupt activities and fraudulent performances as well as foster integrity and liability to achieve better governance
İŞ TATMİNİ BOYUTLARININ İŞ GÜVENLİĞİ UZMANLARI VE İŞYERİ HEKİMLERİ AÇISINDAN KARŞILAŞTIRMASI: AHP UYGULAMASI
Authors: GÜNAY Ziya
Published: December 2018

Çalışanların yaptıkları işten doyum
sağlamaları hem çalışanların iş ve özel yaşamları hem de örgüt ve toplum
açısından önemlidir. Yaptığı işten tatmin olmayan çalışan bireysel örgütsel ve
toplumsal bir kısım kayıpların yaşanmasına sebep olmaktadır. Çalışanlar işin
bir yönünden tatmin olurlarken diğer yönünden tatmin olmayabilirler. İş
tatmininin her bir boyutunun çalışanların genel iş tatmini boyutuna etkisi
farklı olabilir. Bu bakımdan iş tatminin boyutlarının çalışanlar için öneminin
ortaya çıkarılması işverenler ve araştırmacılar için iş tatminin anlaşılmasında
ve çalışanların motive edilmesinde yol gösterici olabilir.  Bu
çalışmanın amacı Bursa ilinde Ortak Sağlık ve Güvenlik Birimleri’nde (OSGB) çalışan
iş güvenliği uzmanlarının ve işyeri hekimlerinin iş tatmini boyutlarına
verdikleri önemi ortaya koymaktır. Araştırmada AHP kullanılarak iş tatmini
boyutlarının önem düzeyleri belirlenmiştir. Araştırmadan elde edilen sonuçlara
göre hem iş güvenliği uzmanları hem de işyeri hekimleri için çalışma
arkadaşları iş tatminin en önemli boyutunu oluşturmaktadır. Ancak C sınıfı iş
güvenliği uzmanları için ücret iş tatmini açısından en önemli boyuttur. Bu
sonuç aynı meslek grubu içinde farklı statülerin iş tatmini boyutlarına farklı
yaklaşımlarının olabileceğini göstermektedir. Araştırmanın sonucuna göre iş
güvenliği uzmanları ve işyeri hekimleri için çalışma arkadaşları iş tatminin en
önemli boyutunu oluşturmaktadır.
The Role of Geterogeneity in Synchronization of Spiking Neural Networks
Authors: Mysin I.E. , Chizhov A.V.
Published: December 2018

The diversity and heterogeneity of neurons and synapses is an important factor in the functioning of the brain. In our work, we investigated the role of heterogeneity
of neural populations in the occurrence of synchronous modes in a network connected by exciting links in the presence of an external exciting input. Using Monte-Carlo
modeling and the semi-analytical modeling the distribution of the refractory density of neuron integrators and Hodgkin – Huxley neurons, we showed that there is a
range of parameters for the stimulating current and the strength of connections in the population where the effects of neuronal heterogeneity on the threshold or on
the stimulating current are opposite. For large values ​​of synaptic weights and subthreshold values ​​of the exciting current, heterogeneity contributes to the emergence
of a synchronous mode in the neural network, while at the same time reducing the coupling strength and increasing the exciting current. The heterogeneity reduces the
tendency of the neural network to synchronize. The results obtained make it possible to reconcile the known data on the effects of heterogeneity in the regulation of
the synchronous regimes arising in the neural ensembles of the brain.
A Spiraea media Fr. Schm. Balaton-felvidéki előfordulásáról
Authors: Varga Szabolcs , Sinigla Mónika , Bauer Norbert
Published: December 2018

A Spiraea media Balaton-felvidéki előfordulása növényföldrajzi szempontból nagy jelentőségű adat, de a populáció pontos helye, mérete és élőhelye a közelmúltig ismeretlen volt. A fel­sőörsi Kopasz-hegyen a közelmúltban megtalált Spiraea media populáció atipikus élőhelyen, egy vi­szonylag zárt cseres-tölgyes erdőben (~Fraxino orni-Quercetum cerridis) található. Egyedeinek virágzá­sa – és a faj megtalálása – feltehetően a szomszédos erdőrészlet letermelése következtében kialakult fénytöbbletnek köszönhető. A 19. századi katonai térképek alapján feltételezhető, hogy a terület koráb­bi vegetációjában jelen lehettek a faj számára kedvezőbb, fényben gazdag sziklás gyep-cserjés-erdő mozaikok, akár sziklai cserjések is.
A potenciálisan inváziós vesszős aggófű (Senecio inaequidens DC.) aktuális elterjedése
Authors: Haszonits Győző , Schmidt Dávid
Published: December 2018

Munkánkban a dél-afrikai eredetű, hazánkban potenciális özönnövénynek számító Senecio inaequidens magyarországi előfordulási adatait foglaljuk össze, valamint beszámolunk néhány újabb hazai megtelepedéséről. Irodalmi, herbáriumi, illetve saját adatokat összegeztünk, valamint ak­tu­a­li­záltuk a faj elterjedési térképét.  Szemléltetjük a faj inváziójának aktuális stádiumát és a termé­szet­kö­zeli élőhelyekre jelentett lehetséges veszélyeit.
A Calamagrostis stricta (Timm) Koeler elterjedése a Dél-Nyírségben
Authors: Demeter László
Published: December 2018

A közlemény a lápi nádtippan elterjedésének feltérképezésében a Dél-Nyírség területén az utóbbi évek során elért eredményeket mutatja be. A korábbról ismert előfordulási helyek ellenőrzé­sén túl számos potenciális élőhely átvizsgálására is sor került. A felmérések nagyobb részben késő ősz­től kora tavaszig történtek, kihasználva a faj száraz levélzetének könnyebb észlelhetőségét. Össze­sen 15 település határában, 19 flóratérképezési négyzetben, 43 lelőhelyen sikerült kimutatni a lápi nádtip­pan előfordulását a vizsgált területen. A vártnál jóval több lelőhelyen került elő, azonban a régi adatok egy részét nem sikerült megerősíteni. Az állományok túlnyomó része igen kicsi, bár néhány esetben az 1000 m²-t elérő összefüggő gyepjei is előkerültek. A termőhelyek legnagyobb sűrűségét, s egyben a legnagyobb kiterjedésű állományokat Penészlek, Fülöp és Nyírábrány határában találjuk. A tapasztalt élőhelyi viszonyok az irodalmi adatoknak megfelelően alakultak. Az eredmények alapján a faj veszé­lyeztetett helyzetét leginkább a vízviszonyok megváltozása okozza. Legalább részben ez eredmé­nyezte, hogy a korábban leírt előfordulások egy részét nem sikerült megerősíteni. A szárazság az élőhe­lyek át­alakulását okozza, és az antropogén zavarásoknak is utat nyithat.
TOURIST AND RECREATIONAL POTENTIAL OF THE LVIV REGION: GEOGRAPHICAL FEATURES OF USE AND RECREATION
Authors: Zapototskyi S. , Horyn I.
Published: December 2018

The paper determines the foundation of formation of a touristic recreational potential of Lviv region. Main contributing factors of development of the tourism industry of the region are investigated. It is established that the largest reserves of recreational resources are located in Drohobych, Zhovkva, Pustomyty, Sokal and Stryj districts. Small amounts of resources are concentrated in Brody, Zhidachiv, Kamenka-Buzka, Mykolayiv, Peremyshlyansk, Radekhiv, Sambir and Turka districts.

Tourist routes of Lviv region were estimated. In particular, the most promising ones were evaluated, including the Golden Ring of the Boykivshchyna, the Russky Path – the old way through the Carpathians, Makivka – the mountain of the immortal glory of the Ukrainian Sich Riflemen.

The correlation-regression relationship between the indicators forming the tourist flows and the main components of the tourism development of the studied region was determined.

The level and intensity of current usage of the potential of the region were estimated. SWOT-analysis of touristic and recreational potential of the region was carried out. The study of a touristic and recreational sector of Lviv region has made it possible to establish that its development depends primarily on the advantageous geographical location of the region, rich natural-resource and historical and cultural potential, and the development of touristic and recreational infrastructure.

It was established that the region has all the necessary preconditions for the long-term development of cultural-cognitive, scientific-educational, religious, medical, hunting, ecological, business, sports and excursion types of the tourism industry. Particularly important and promising is the development of rural (green) tourism in the region. The development of touristic and recreational sphere of Lviv oblast depends, first and foremost, on the rational use of natural and cultural-historical resources, the reconstruction of sanatoriums and resorts, recreational and touristic establishments, the creation of material and technical base for the development of touristic and recreational industry, promotion of investment attraction, distribution of touristic product on the domestic and world markets and strengthening of international cooperation in the field of tourism and recreation.
PROSPECTS FOR THE DEVELOPMENT OF INDUSTRIAL TOURISM ZAKARPATSK REGION
Authors: Penderetsky O.
Published: December 2018

Along with the folk crafts of the Transcarpathian region, an industrial tour is being developed in conjunction with industrial and natural objects that make up its resource potential. In the context of reforming economic relations, the emphasis is on the development of priority economic sectors – the forest and wood industry, light and food industries, the development of cross-border cooperation, recreation and tourism, etc. The main attention is paid to the further restructuring of the entire national economic complex, the involvement of domestic and foreign investments in the economy, the development of small and medium-sized businesses, and the effective use of natural resource potential. It is proved that the condition of full awareness of tourists is the creation of a passport of an industrial tour, which includes ecological, technical, and cadastral. Tours on mines from salt mining, precious metals, sulfur mines, oil wells, mineral water, ozocerite, objects of the former military complex – rocket mines, storage facilities, warehouses, enterprises for processing raw materials and materials, folk crafts are promising the direction of development of industrial tourism in Transcarpathia.

Industrial tourism, as part of the overall tourist process in Ukraine, can be directed at solving many socio-economic tasks of local communities, the most important among them is increase of employment, growth of its welfare, provision of socio-cultural development of the region and improvement of quality of life of people.

Today, in order to increase the competitiveness of the region in the tourism industry, the cluster method, which was previously used only in industrial production, is used. A tourist cluster [5] is a key organizational framework that combines tourism and other related industries into a single system that enables the enterprises, institutions and organizations to meet the priority objectives and enhance the competitive advantages of the region. By creating such an association, financing and implementation of even very ambitious projects in the tourism sector could be provided, which would otherwise be impossible for each individual participant.

The developed map of the territorial placement of centers of industrial tourism in the Transcarpathian region greatly simplifies the creation of an informative cadastral system and on its basis industrial tours. At the same time, the improvement of this system requires the systematic introduction of new information indicators, taking into account the change in structural and functional relationships between different departments.

In general, Transcarpathia has an all-Ukrainian significance in the economic plan as a region with significant potential of the forest and wood industry, winemaking, vegetable growing, dairy industry, tobacco production, mineral waters.
Results of studying disinfectant-resistance of bacteria, excreted from patients in microbiological provision of epidemiological surveillance of hcai at multitype medical institution
Authors: Nesterova D. D. , Neshataev A. N. , Lukyanenko N. V. , Petrova A. A. , Prokopyev V. V. , Sergeev T. S.
Published: December 2018

Aim. To improve microbiological monitoring of disinfectant-resistance of microorganisms, excreted from clinical material in epidemiological surveillance of HCAI.

Materials and methods. Over the period from 2012 to 2016, while conducting resistance monitoring, 3320 investigations of clinical material were performed. The number of studied microorganisms was 1557. The number of excreted disinfectant-resistant microorganism strains was 337. The studies of microorganisms from clinical material for resistance were realized to 48 disinfectants of 15 groups with different reactants.

Results. During the present study it was established that microbiological monitoring, oriented for continuous monitoring of microorganisms circulation will permit to increase the number of studies in 2016 by 2.6 times, to reduce the total number of disinfectant-resistant flora in 2016 by 62 %. The greatest weight of excreted cultures was in the units of surgical profile – 48.8 %, resuscitation profile – 30 %, therapeutic one – 21.2 %. Clinical material, from which positive results were obtained, was determined by scourage (from 43.5 % in the surgical unit to 74.8 % in therapeutic), blood sterility (from 2.7 % in therapeutic units to 31.4 % in resuscitation units). Microflora, excreted from clinical material is presented predominantly by P. aeruginosa – 24.0 %, Kl. pneumoniae – 30.0 %, E. coli – from 12.9 to 22.1 %, St. aureus – from 3.0 to 7.6 %. The studies regarding disinfectant-resistance to 48 items from 15 groups of chemical compounds are the evidence of growing resistance to QAC, including QAC + amines – 24.7 %, QAC + aldehyde-containing – 6.8 %, chlorine-containing – 21.9 %. The highest resistance to disinfectants used was in Acinetobacter spp., Kl. pneumoniae, P. aeruginosa, E. coli.

Conclusions. The developed algorithm of microbiological study, based on software, permitted to form the database, to monitor epidemiologically significant microorganisms and correct choice of disinfectants and disinfection tactics.
Personified approaches to organization of risk-oriented medical observation in conditions of opportunistic-pathogenic microbial air contamination of working zone
Authors: Masyagutova L. M. , Gizatullina L. G. , Vlasova N. V. , Khairullin R. U. , Sadrtdinova G. R. , Bakirov A. B.
Published: December 2018

Aim. To ground the personified approaches when organizing risk-oriented medical observation of animal breeding workers.

Materials and methods. The total capillary blood analysis with calculation of percentage of peripheral blood cellular composition was carried out, allergization index (AI) and immunoreactivity index (IRI) was assessed, the total number of microorganisms per 1 m3 of the air in the working zone was determined, the total microbial count (TMC) was calculated.

Results. The standard periodic medical examination of workers is sufficient with TMC value less than 500 CFU/m3, absence of chronic infectious inflammatory diseases (CIID), AI value less than 1.08 standard units, IRI value less than 13 standard units. When having a mean level of microbiological risk, CIID detection ranging from 1 to 3, AI value less than 1.08 and IRI value less than13 standard units, it is recommended to add a survey to the previous stage, using special questionnaire (attitude to work, working conditions, fatigability degree, susceptibility to allergy etc.). When having TMC value more than 2500 CFU/m3, CIID detection from 4 to 5, AI value 1.08–1.3 standard units, IRI value 13.1–15.7 standard units, an additional study of the upper airways microflora as well as immune status using tests of the first level should be realized; further recommendations on treatment-and-preventive measures in outpatient conditions should be given; with TMC value more than 5000 CFU/m3, presence of CIID – 6 and more, AI value 1.4–1.5 standard units, IRI value 15.8–18.3 standard units, it is recommended to perform immunological studies using tests of the second level with determination of susceptibility to antimicrobial preparations in hospital conditions of Occupational Pathology Center.

Conclusions. The method of personified risk-oriented medical observation of persons, working in animal breeding is offered.
Influence of non-motor manifestations of Parkinson’s disease on quality of life
Authors: Khegai O. V. , Selyanina N. V. , Karakulova Yu. V.
Published: December 2018

Aim. To estimate the degree of influence of non-motor manifestations on the quality of life among patients with Parkinson’s disease.

Materials and methods. In the study, the “case-control” design was used, processing of the data was conducted with nonparametric methods. Complex examination of 58 patients with Parkinson’s disease was performed. The control group included 15 healthy persons.

Results. Manifestation of cognitive, anxiety-depressive, vegetative symptoms in the main group was significantly higher than in the control. There was revealed a negative correlation dependence between the general manifestation of vegetative disorders and the social functioning indices (R = – 0.5; p = 0.001), pain intensity (R = – 0.5; p = 0.001) and psychical health (R = – 0.5; p = 0.005) that proves aggravation of the data on health components as the severity of symptoms was growing. The analyzed vegetative disorders of separate subsystems demonstrated the analogous tendencies. Severity of depressive symptoms influences the pain indices (R = – 0.4; p = 0.01) and the social functions (R = – 0.3; p = 0.03). According to unified scale, non-motor symptoms negatively influence the general health status (R = – 0.3; p = 0.001), social functioning (R= – 0.23; p = 0.004), pain assessment (R = – 0.5; p = 0.001).

Conclusions. Non-motor symptoms aggravate the quality of life, influencing both physical and psychological component of health. The absence of correlation between the duration of therapy and the severity of non-motor symptoms confirms the independence of this block of symptoms.
Optimized use of eight-arm maze when studying effect of preparation “Cycloferon®” on cognitive potential of experimental animals
Authors: Kuznetsov S. V. , Kuznetsov V. F. , Makunina E. V. , Kasimova R. M. , Tyutyunschikova V. D. , Obernebesova T. P.
Published: December 2018

Aim. To develop the testing algorithm in conditions of radial eight-arm maze and to study the effect of preparation “Cycloferon®” on cognitive processes in experimental animals in conditions of repeated training.

Materials and methods. The study was conducted on experimental animals – white outbred male rats (n = 21) aged 8–9 months using the original method. “Radial eight-arm maze” was used as experimental laboratory device. During the experiment, to activate searching behavior, daily nutrition regime was reduced by 15–20 %. To fortify, milk product “Thickened milk” was used. At the first experimental stage, the animals received a typical vivarium ration. During the second part of this study, the rats underwent repeated training after taking “Cycloferon®”, calculated for each rat by the mass – 0.77 mg per 100 g of the animal body mass; after that the rats’ spatial memory was assessed.

Results. Taking into account the results of the second part of experiment, statistically significant tendency to increase was revealed among animals with positive result of testing with one-sided Fisher criterion (p = 0.037). No correlation between taking “Cycloferon®” and the number of repeated entering of the arms and the total number of entering of the arms was detected (p > 0.05) that proves the formation of purposive movement.

Conclusions. A reliable tendency to increase in the number of animals, trained during the repeated testing against the background of using “Cycloferon®”, which possesses immunomodulating effect as well as antioxidant action, confirms the actuality of applying the offered method while studying cognitive effect of substances, requiring long-term introduction.
Clinicodiagnostic problems of hepatic fibrosis/cirrhosis
Authors: Schekotova A. P. , Bulatova I. A. , Paducheva S. V.
Published: December 2018

The problems of hepatic fibrosis/cirrhosis diagnosis are discussed in the paper. At the modern stage, diagnosis of chronic hepatic diseases is based on laboratory, instrumental, morphological methods of study and calculated indices. Puncture biopsy of the liver is referred to the most reliable diagnostic methods. However, there are some complexities while implementing this procedure, which do not permit to use morphological studies for dynamic observation. The method of ultrasound elastometry is offered as an alternative to puncture biopsy of the liver. However, it also has some technical limits that resulted in development of noninvasive, in particular, laboratory methods of hepatic fibrosis/cirrhosis diagnosis.
Línea jurisprudencial sobre las limitaciones a la libertad contractual a la luz del derecho constitucional a la vivienda digna
Authors: Cataño Berrío Sandra Eliana
Published: December 2018

El propósito de este escrito es presentar las tensiones existentes entre la libertad contractual, como una de las manifestaciones de la autonomía privada, y el derecho constitucional a la vivienda digna mediante el análisis de la jurisprudencia de la Corte Constitucional de Colombia, con el fin de establecer las reglas controlantes en materia de derecho contractual y de obligaciones cuando se está en presencia de negocios jurídicos para la financiación de vivienda a largo plazo. Para esto, se hace relación a un contexto necesario para la formulación de la línea jurisprudencial; luego, se ofrece la reseña de las sentencias analizadas, y se finaliza con la presentación de la línea y las reglas vigentes sobre este aspecto, las cuales son de obligatoria observancia por parte de todos los operadores jurídicos al momento de configurar y ejecutar relaciones jurídicas que tengan como objeto el crédito de vivienda.
GEMİ VE LİMAN ETKİLEŞİMİ İÇİN ÖNERİLEN ENERJİ YÖNETİM SİSTEMİ MODELİNİN İNCELENMESİ
Authors: YİĞİT Kenan , ACARKAN Bora
Published: December 2018

Bu çalışmada, yeni
nesil gemi ve liman tasarımı konseptlerine uygulanabilecek ve gemilerin limanda
iken alternatif enerji kaynaklarını kullanarak elektrik enerjisi ihtiyacının
karşılanmasına imkân tanıyacak bir enerji yönetim modeli önerilmiştir. Bu model
ile gemiler limandaki operasyonlarını gerçekleştirirken finansal ve çevresel
şartları göz önüne alarak hem kendi jeneratörlerini kullanabilecek hem de
ulusal şebekeye etkin bir şekilde bağlanabilecektir. Bu sayede, gemi
mürettebatı bulunduğu limanda uluslararası sözleşmelerden kaynaklı çevresel bir
kısıtlama var ise bu kuralları karşılamak için en temiz enerji kaynağını
seçebilecektir. Çevresel kısıtlamaların karşılandığı bir limanda ise en
ekonomik enerji kaynağını kullanarak enerji maliyetlerinde tasarruf
sağlayabilecektir.

Çalışmada, gemi
enerji yönetim modeli ve benzetim çalışması için MATLAB programı kullanılmıştır.
Benzetim çalışmasında, kabul edilebilir sonuçlar elde etmek için “M/V İnce Hamburg” isimli yük
gemisine ait veriler ile Türkiye ulusal şebekesine ait gerçek veriler dikkate
alınmıştır. Sadece kendi jeneratörlerini kullanan gemi ile enerji yönetim
sistemine sahip ve ulusal şebekeye bağlanabilen gemi için elde edilen sonuçlar karşılaştırılmıştır.
Sonuçlar, önerilen sistem ile enerji maliyetinde yaklaşık %46’lık bir tasarruf,
CO2 salımında ise yaklaşık
%33’lük bir azalma sağlanacağını göstermektedir.