bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlation Between Low THBS3 Expression in Peripheral Blood and Acute Myocardial Infarction
Authors: Chen Yanqiu , Meng Heyu , Meng Xin , Yan Zhaohan , Wang Jingru , Meng Fanbo
Published: October 2022

Background: Thrombospondin (THBS) 3 is an adhesive glycoprotein involved in cell-cell and cell-matrix interactions. The purpose of this study is to determine whether THBS3 expression in peripheral blood can be used as a biomarker to predict the risk of acute myocardial infarction (AMI). Methods: The peripheral blood of 111 patients with stable coronary artery disease (SCAD) and 112 patients with AMI was obtained. The experimental and the control cohorts were the AMI and SCAD groups, respectively. The expression of THBS3 mRNA and protein in both groups was determined using reverse-transcription polymerase chain reaction and enzyme-linked immunosorbent assay. Results: THBS3 expression (range) in the peripheral plasma of patients in the AMI group was lower than that of patients in the SCAD group (4.526 (3.748–5.521), 5.511 (4.726–6.334), respectively), which was 0.82 times lower than the control (p < 0.001). Furthermore, THBS3 mRNA level in the peripheral blood mononuclear cells of patients with AMI was 0.47 times lower than that in patients with SCAD (p < 0.05). AMI was associated with fasting blood glucose levels, platelet counts and low THBS3 expression. Logistic regression analysis revealed that decreased expression of THBS3 protein increased the probability of AMI by 4.076 times (p < 0.01). Additionally, high fasting blood glucose and high platelet counts increased the risk of AMI by 2.819 and 6.515 times, respectively (p < 0.05). Conclusions: THBS3 mRNA and protein levels in the peripheral blood of patients in the AMI group were much lower compared with those of patients in the SCAD group. Low THBS3 expression in peripheral blood was related to AMI and was an independent risk factor for AMI. Thus, low THBS3 expression in peripheral blood may be a novel, suitable molecular marker for the early detection of AMI.
Nitro-Oxidative Stress and Mitochondrial Dysfunction in Human Cell Lines Exposed to the Environmental Contaminants PFOA and BPA
Authors: Magnifico Maria Chiara , Xhani Marla , Sprovera Benedetta , Buttari Brigitta , Abballe Giorgia , Desideri Flaminia , Panieri Emiliano , Saso Luciano , Arese Marzia
Published: October 2022

Background: Bisphenol A (BPA) and perfluorooctanoic acid (PFOA) are synthetic compounds widely utilized in industrial activities devoted to the production of daily life plastic, metal products, and packaging from which they are able to migrate to food and water. Due to their persistence in the environment, living organisms are chronically exposed to these pollutants. BPA and PFOA have adverse effects on tissues and organs. The aim of this study was to identify the molecular targets and biochemical mechanisms involved in their toxicity. Methods: HepG2 and HaCaT cells were treated with BPA or PFOA, and the trypan blue exclusion test and 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) assay were performed to define the conditions for subsequent investigations. We conducted quantitative PCR and western blot analysis to evaluate the expression of proteins involved in nitric oxide (NO) signaling. Cell-based assays were carried out to evaluate reactive oxygen species (ROS) production, nitrite/nitrate (NOx) accumulation, 3-nitrotyrosine (3-NT) formation, and mitochondrial membrane potential (MMP) determination in treated cells. Results: HepG2 and HaCaT cells incubated for 24 h with subtoxic concentrations of BPA or PFOA (50 and 10 μM, respectively) exhibited altered mRNA and protein expression levels of NO synthase isoforms, manganese superoxide dismutase, and cytochrome c. Treatment with PFOA led to activation of inducible NO synthase (NOS), a marker of nitrosative stress, accompanied by the increased production of ROS, NOx, and 3-NT and alterations of the MMP compared to controls. Conclusions: The results of this study indicate the major involvement of the NO signaling axis in the persistent alteration of cell redox homeostasis and mitochondrial dysfunction induced by BPA and PFOA, highlighting the specific role of PFOA in NOS regulation and induction of nitro-oxidative stress.
The Role of the GRP78/PERK/ATF4 Pathway in the Ability of Gua Lou Gui Zhi Decoction to Attenuate Apoptosis by Inhibiting Endoplasmic Reticulum Stress after Ischemia-Reperfusion Injury
Authors: Chen Yaping , Chen Zheming , Cheng Weineng , Cao Yajun , Xu Wen , Lai Wenfang , Zhang Yuqin , Huang Mei , Nan Lihong
Published: October 2022

Background: Endoplasmic reticulum stress (ERS) is a key part of the apoptotic cascade that is initiated after cerebral ischemia-reperfusion injury and is very important for research on poststroke rehabilitation. In addition, the unfolded protein response (UPR) plays an important role in ERS because it activates downstream apoptotic signal transduction and induces apoptosis through the glucose-regulated protein 78 (GRP78)/protein kinase R (PKR)-like ER kinase (PERK)/activating transcription factor 4 (ATF4) pathway. The Gua Lou Gui Zhi Decoction (GLGZD) ameliorated neuronal apoptosis of ischemia-reperfusion injury caused by middle cerebral artery occlusion (MCAO) had been proved in our previous study. The present study aims to underly the regulatory ability of GLGZD in ERS-induced apoptosis mediated by the GRP78/PERK/ATF4 pathway. Methods: GLGZD was analyzed by HPLC. The effects of GLGZD were obversed on MCAO-induced ischemic rats. The cerebral infarct volume was detected by 2,3,5-Triphenyl-2H-Tetrazolium Chloride (TTC) Staining. Terminal Deoxynucleotidyl Transferase-Mediated dUTP-Biotin Nick End Labeling (TUNEL) were used to detect apoptosis. Transmission Electron Microscopy (TEM), Ca2+ levels and reactive oxygen species (ROS) detection were used to determine the function of endoplasmic reticulum. The GRP78/PERK/ATF4 signaling pathway was assessed by western blotting and immunohistochemistry. Results: Our results showed that GLGZD exerted its effects on ischemia-reperfusion injury by significantly promoting the restoration of the quantity and morphology of the rough ER and reducing the neuronal apoptosis rate in the ischemic cortex. Moreover, both of the intracellular ROS and Ca2+ levels in ischemic cortical cells were found significantly reduced by GLGZD. The GLGZD-treated group showed increased levels of phosphorylation in both of PERK and eukaryotic translation initiation factor 2α (eIF2α), activation of cysteinyl aspartate-specific proteinase-3 (Caspase-3), upregulation of the total protein levels of sarcoplasmic/endoplasmic Ca2+ ATPase 2α (SERCA 2α) and B-cell leukemia/lymphoma gene 2 (Bcl-2). Conclusions: These findings suggest that GLGZD reduces oxidative stress-induced injury and promotes a dynamic calcium balance, thereby inhibiting ERS and exerting an antiapoptotic effect on neuronal ischemic injury, which are closely related to the activation of GRP78/PERK/ATF4 signaling pathway.
Interdisciplinarity and Patient Engagement: New Representations of Cardiovascular Anatomy
Authors: Biglino Giovanni , Layton Sofie , Hamer Alastair , Milano Elena Giulia , Caputo Massimo , Wray Jo
Published: October 2022

Background: This article presents and discusses the genesis, making and public presentation of two artworks by British artist Sofie Layton, namely Blueprints and The Bud, which explore the anatomy of the heart infusing it with experiential and narrative elements. Methods: Artist-led workshops with a range of audiences (cardiac patients, medical staff, medical students, creative professionals, and patient relatives) led to explore narratives and imagery that, in turn, was re-presented in artworks exploring the complexity of the cardiovascular system. Results: While positioning themselves in a long tradition of artistic representations of the heart, often purely anatomical or autobiographical, these artworks stem from a process of patient involvement and participation. Integral to the pieces is an interdisciplinary approach, which is central to arts-and-health collaborations. Conclusions: At a time in which the role of the arts in improving health and wellbeing is increasingly recognised and supported by evidence, these artworks offer an opportunity to reflect not only on ways of representing cardiovascular anatomy, but also on its experiential value and on the important of patient engagement and involvement.
Atrioventricular Ring Tachycardias: Atypical Fast-Slow Atrioventricular Nodal Reentrant Tachycardia and Atrial Tachycardia Share a Common Arrhythmogenic Substrate—A Unifying Proposal
Authors: Kaneko Yoshiaki , Tamura Shuntaro , Kobari Takashi , Hasegawa Hiroshi , Nakajima Tadashi , Ishii Hideki
Published: October 2022

Our understanding of the variants of slow pathway (SP) and associated atypical atrioventricular (AV) nodal reentrant tachycardia (NRT) is still growing. We have identified variants extending outside Koch’s triangle along the tricuspid annulus, including superior, superoanterior and inferolateral right atrial SP and associated atypical, fast-slow AVNRT. We review the history of each variant, their electrophysiological characteristics and related atypical AVNRT, and their treatment by catheter ablation. We focused our efforts on organizing the published information, as well as some unpublished, reliable data, and show the pitfalls of electrophysiological observations, along with keys to the diagnosis of atypical AVNRT. The superior-type of fast-slow AVNRT mimics adenosine-sensitive atrial tachycardia originating near the AV node and can be successfully treated by ablation of a superior SP form the right side of the perihisian region or from the non-coronary sinus of Valsalva. Fast-slow AVNRT using a superoanterior or inferolateral right atrial SP also mimics atrial tachycardia originating from the tricuspid annulus. We summarize the similarities among these variants of SP, and the origin of the atrial tachycardias, including their anatomical distributions and electrophysiological and pharmacological characteristics. Moreover, based on recent basic research reporting the presence of node-like AV ring tissue encircling the annuli in adult hearts, we propose the term “AV ring tachycardia” to designate the tachycardias that share the AV ring tissue as a common arrhythmogenic substrate. This review should help the readers recognize rare types of SP variants and associated AVNRT, and diagnose and cure these complex tachycardias. We hope, with this proposal of a unified tachycardia designation, to open a new chapter in clinical electrophysiology.
Association of Soluble IL-1 Receptor Type 2 with Recovery of Left Ventricular Function and Clinical Outcomes in Acute Myocardial Infarction
Authors: Liu Sui-Feng , Liu Song , Yu Qiao-Ting , Gao Tang-Gang , Zhang Yang , Cai Jia-Yi , Jia Chun-Wen , Zhao Ya-Nan , Gao Feng
Published: October 2022

Background: The role of soluble interleukin-1 receptor type 2 (sIL-1R2) in acute myocardial infarction (AMI) remains undocumented. In the present study, we aimed to evaluate the possible associations of sIL-1R2 with left ventricular (LV) function, remodeling and future clinical events in the setting of AMI. Methods: Circulating sIL-1R2 levels were quantified after percutaneous coronary intervention (PCI) on day 1 of hospital admission for 204 AMI patients, and upon enrollment of 204 healthy controls. Echocardiography was conducted in the acute phase and at 12-month follow-up. Adverse clinical events were registered after 12 months. Results: Circulating sIL-1R2 levels were significantly higher in AMI patients than in healthy controls (medians respectively 6652.81 pg/mL, 3799.13 pg/mL, p < 0.0001). AMI patients with sIL-1R2 levels less than the median had a larger proportion of worsened LV ejection fraction [a decrease in LV ejection fraction (LVEF) of more than 10% units] and reduced LVEF (a final LVEF <50%). After multivariate adjustment, sIL-1R2 levels less than the median were associated with an increased risk of worsened LVEF [odds ratio (OR): 3.7, 95% confidence interval (CI): 1.6–8.5, p = 0.002] and reduced LVEF at 12 months (OR: 2.1, 95% CI: 1.1–4.3, p = 0.035). Moreover, low sIL-1R2 levels were associated with an increased risk of having an adverse clinical event during the first 12 months after AMI [hazard ratio (HR): 2.5, 95% CI: 1.0–6.1, p = 0.039]. Conclusions: Low levels of circulating sIL-1R2 were associated with impaired recovery of LV function and adverse clinical outcomes in AMI patients. These findings might contribute to understanding the important role of sIL-1R2 in postinfarction inflammation.
Parent's Engagement in the Learning Needs of Learners with Down Syndrome in the New Normal Education
Authors: Hinggo Jeny , Naparan Janus , Naparan Genesis
Published: October 2022

This study probed parental engagement in the learning needs of the learners with Down syndrome (DS) in their homes in Zamboanga Sibugay, Philippines, during this new normal education. Parents of a child with DS were the primary participants of this study. Merriam’s case study approach was utilized as a research design. Multiple data sources were considered, such as interview transcripts and observation notes during the actual interview. The results show that parents exerted more effort to ensure their children's educational success amidst the pandemic. The findings of the study reveal parents' efforts to catch the attention of their children during the delivery of learning at home. Although parents struggled to extend their children's limited attention span, they managed to find suitable strategies to keep their focus, like using different reinforcements and utilizing videos from social media platforms to teach their children. It is recommended that parents or guardians of children with DS consider pieces of training on how to effectively facilitate their children's learning process. Special Education (SPED) teachers must guide the parents on how to facilitate learning at home together with the school principal, who could initiate teaching pedagogy seminars and training for parents. The seminars and training would help parents and guardians facilitate their child's learning process.
Effectiveness of Jolly Phonics Program towards Strengthening of Language Literacy: Experimental Case in the Philippines
Authors: Belbes Maura E , Bandoy Marcial M , Tan Consorcia S , Yazon Alberto D , Buenvinida Lerma P
Published: October 2022

The Programme for International Student Assessment result of being the lowest in reading comprehension is the main reason that compelled the researcher to conduct the study with the use of the Jolly Phonics program in strengthening language literacy. In addition, at the Division of Cabuyao, there is an issue regarding reading difficulties among Grades 1 to 3 of selected public elementary schools. Despite many strategies being applied, they still find it difficult to read and comprehend. The purpose of this paper is to determine the effectiveness of the Jolly Phonics program in strengthening language literacy and test the hypotheses that there is no significant relationship between the performance of the two groups considering the results of the post-test in language literacy. There were two groups of participants in the study, the experimental group, who utilized the Jolly phonics program, and the comparison group, who were subjected to the Marungko approach. Each approaches utilized thirty (30) pupils from Grades 1 to 3, combining the sum total of 540 participating pupils for three selected elementary schools. The instrument used was the pretest and post-test validated by experts from the City School Division Office. A quasi-experiment research design guided the conduct of the study. A frequency percentage distribution, t-test for independent means, and Analysis of Variance (ANOVA) were among the statistical tools employed in the study. Findings revealed that there was a significant difference in the performance between and among the participating public elementary schools (ES)for Grades 1 to 3. For instance, in Grade 1, it was noted that the performance of Banay – Banay ES was a bit higher than Butong ES and was considerably higher than that of San Isidro ES; In Grade 2, Banay – Banay ES topped in their reading performance compared to other two elementary schools; and  In Grade 3,  San Isidro ES at this time showed better performance, running over in reading proficiency the other two elementary schools. The action plan was proposed by the researcher of the study to strengthen the language literacy of the learners in the Division of Cabuyao
Leadership Practices, Adversity Quotient, And School-Based Management Practices In The New Normal: A Descriptive-Correlational Approach
Authors: Aya Mary Kris Faye D , Buenvinida Lerma P , Tan Consorcia S , Bandoy Marcial M , Manaig Karen A
Published: October 2022

This study investigated the relationship between the leadership practices, adversity quotient, and school-based management practices in the new normal. It employed a descriptive-correlational design with an online survey as the primary data collection tool. The respondents are 104 school heads and 597 teachers from public elementary schools in the City Schools Divisions of Biñan, Cabuyao, Calamba, and Sta. Rosa. Frequency Count, Percentage, Mean, Standard Deviation, and Pearson Product Moment of Correlation were the statistical tools utilized to analyze and interpret the data gathered. The findings revealed that school heads highly practiced the new normal leadership practices in terms of adaptability, decision-making, and planning and implementation as perceived by teachers. For the adversity quotient, teachers indicated below average adversity quotient while the school heads indicated average adversity quotient. The respondents assessed the extent of SBM practices as the presence of evidence indicating practices and procedures satisfying quality standards. Correlation analyses denoted a significant relationship between perceived school heads' leadership practices and assessed SBM practices and between teachers' adversity quotient and assessed SBM practices. Only the control dimension of the adversity quotient of school heads indicated a significant relationship with assessed SBM practices in terms of leadership and governance, accountability and continuous improvement, and management of resources.
A Phenomenological Studies of Special Education Teachers and Parents Lived Experiences In Upholding Learners With Disability (Lwd) In Transition Program During Pandemic
Authors: Villareal Sheila J , Panopio Jr Francisco P , Tan Consortia S , Bandoy Marcial M , Buenvinida Lerma P
Published: October 2022

The implementation of a transition program for special education students is hardcore during face-to-face and it became more difficult to implement during distance education. The research aimed to explore the essence of the experiences of Special Education (SPED) teachers and parents under the transition curriculum. This study utilized qualitative design. Particularly, this study employed a phenomenological research design. The participants of this study were eight (8) parents having LWD at home enrolled in the school SY 2021-2022 under Special Education Program and five (5) SPED teachers. The information and replies of the participants were gathered using a semi-structured interview guide. Coding and triangulation were done to analyze and identify the emerging theme. The emerging themes for the teachers lived experiences revealed flexibility and adaptability in times of pandemic, the power of communication, and effective problem-solving strategies. For the parents, the main themes that emerged from their testimonies were the needs for assistance and parent as a manager. The findings also revealed that all problems related to the transition curriculum were addressed and solved by teachers and parents by working with each other. Knowing how parents struggles due to their work and parental roles helped the teachers to understand them and help them build a strong relationship based on trust and understanding. The researcher recommended that the school may intensify the relationship between the teachers and parents by improving communication, collaboration, and cooperation between them. To help the parents more in assisting their kids, parenting techniques, mentoring, and coaching programs may be provided.
Effectiveness of Home Economics Learning Commons (HELCs) in Enhancing the Academic Performance of Grade 5 Learners: A Quasi-Experimental Research
Authors: Endaya Grace C. , Manaig Karen A. , Yazon Alberto D. , Tesoro John Frederick B. , Tabuac Erica B.
Published: October 2022

This quasi-experimental research design determined the effectiveness of the Home Economics Learning Commons (HELCs) in improving the academic performance of Grade 5 learners. It utilized the formative, summative, and post-tests as part of the research instruments. Match-pairing technique was used to determine the participants of the study. The said participants were the Grade 5 pupils from five different Cabuyao Elementary Schools. The comparison group consisted of students enrolled in the Online Distance Learning modality, while the experimental group consisted of students enrolled in the Modular Distance Learning modality. Based on the data gathered, it revealed that the mean scores in the formative test were high in both the comparison and experimental groups, while the mean scores in the summative test varied from 54-73% and were interpreted as average to near to mastery; and mean scores in the post-test ranged from 14-18.50%, considered as average to high. There was a substantial difference in the Pre-test and Post-test Mean Scores of the five participating schools' Comparison and Experimental Groups, according to the results of the Paired t-Test. Hence, the study concluded that there is a significant difference between the formative tests' mean scores of the two groups. Likewise, there is a significant difference between the post-test mean scores of the two groups. Lastly, there is a significant difference between the pre-test and post-test mean scores of each group. As a result, it was established that HELCs have a considerable positive effect on students' academic achievement.
Development and Validation of Comic-based Learning Module in Physics
Authors: Badeo Jeah May , Ong Kian Koc Bee Ching
Published: October 2022

Providing instructional materials that support the diverse learning styles and needs of 21st-century learners is becoming a trend in today's online learning. Thus, this descriptive developmental research design aimed to develop Comic-based Learning Modules (CLM) as instructional material envisioned to meet these learners' needs for a better understanding of Physics concepts. This study employed the ADDIE model for the instructional material development design. The initial developed CLM was revalidated following the comments and suggestions of the validators before distribution for online learning. Four experts validated the CLM in terms of content/lessons, illustrations, additional features, language, layout, and overall presentation using a researcher-made criterion-based reference evaluation tool. The validators rated the developed instructional material featuring three CLM as "Highly Acceptable" (4.66). The value of the average inter-rater reliability coefficient kappa of the ratings of the validators is interpreted as "Substantial Agreement" (0.63). CLM was then implemented as instructional material and found to have high usability as rated by the students. Also, the CLM drew positive feedback for online learning use because of its exciting nature and uniqueness.
Pedagogical Innovative Methods and Classroom Management in Nigeria
Authors: Kadir Abdullahi Nimota jibola
Published: October 2022

The primary goal of this research was to determine the relationship between innovative pedagogical methods and classroom management. Traditional pedagogy has been found to be out of date in recent years, especially in terms of how teachers deliver their teaching and management of the classroom. The time is right to recognize cutting-edge educational pedagogical innovative methods that are currently being implemented on a world wild scale or locally, depending on the needs of the region. A quantitative research design was adopted for the study. A sample of 761 participants was selected randomly selected from the sample public primary schools in the North-west zone, Nigeria. Pearson product-moment correlation coefficient and linear regression analysis were used to test the hypotheses. The findings revealed that computational thinking-embodied learning and context-based learning positively and significantly correlated with classroom management. Therefore, it was recommended that School managers should continue to encourage learners' computational thinking so as to help learner experience a deeper level of involvement and understanding. Also, school managers should continue to improve embodied learning in order to help teachers reach out to the mind of learners and make lessons more interesting. Furthermore, school managers should encourage context-based learning by giving learners a perfect degree of autonomy over learning activities, helping learner activate their thinking and meta-cognitive skills toward achieving effective classroom management.
Kaitan Pembelajaran Bahasa Indonesia dengan Lingkungan
Authors: Syahfira Medita , Oktaria Yepil
Published: October 2022

Lingkungan memiliki pengaruh yang besar jika dikaitkan dengan pembelajaran bahasa Indonesia. Pembelajaran bahasa Indonesia berbasis lingkungan dapat membantu peserta didik dalam menguasai pembelajaran bahasa Indonesia. Lingkungan yang baik dan kondusif akan membantu peserta didik dalam meningkatkan kreativitas dan inovatif dalam pembelajaran bahasa Indonesia. Selain itu, lingkungan dapat membantu peserta didik untuk menjaga lingkungan yang ada di sekitarnya melalui pembelajaran bahasa Indonesia.
Kaitan Pembelajaran Bahasa Indonesia dengan Lingkungan
Authors: Syahfira Medita
Published: October 2022

Lingkungan hidup adalah segala sesuatu yang berada di sekeliling manusia sebagai pribadi atau di dalam proses pergaulan hidup dan hubungan antara berbagai organisme tempat tinggalnya. Seorang intelektual terkhusus siswa, inilah yang menjadi kebutuhan primernya yang terjadi secara sadar atau kurang sadar dalam menjalani kehidupannya. Antara manusia dan lingkungan hidupnya terdapat hubungan yang timbal balik. Manusia mempengaruhi lingkungan hidupnya, dan sebaliknya manusia dipengaruhi oleh lingkungan hidupnya dan tidak terpisahkan satu sama lain.
Monetary transmission mechanism analysis in a small, open economy: the case of Vietnam
Authors: Nguyen Ha Thanh
Published: October 2022

The transmission mechanism of monetary policy describes the dynamic stages in which a central bank’s monetary policies are transmitted to real output and prices. It plays a crucial, perhaps even central, role in the study of monetary economics. However, few studies have focussed on developing small, open economies, and even fewer have covered characteristics such as the aggregate demand components, the low independence of monetary policy, the weak developing financial markets and structural changes in the economy. Few quantitative empirical studies have been conducted on the monetary transmission mechanism in Vietnam, and they do not include a non-recursive structural vector autoregression model with structural breaks, and characteristics of a small, open economy. This study attempts to fill such research gaps.The aim of this thesis is examining the role of monetary policy in the Vietnamese economy, in terms of shocks to the economy via different channels, and the international dimension of the monetary transmission mechanism in the small, open economy of Vietnam. To answer these questions, the study uses quarterly data for the period 2000:1 to 2011:4 and the Structural Vector Autoregression (SVAR) approach. The SVAR is more suited than the Vector Autoregression (VAR) approach to examining structural shocks as a test of multivariate models. The findings show that the statistically significant break dates are found in this study, so a dummy variable is included in the SVAR model of Vietnam.The study’s findings reveal that the impacts of a monetary contraction on domestic variables are largely consistent with theories, except for its impact on price level. A monetary contraction causes the output to decrease, but weak. The monetary channels explain about 20 percent of fluctuations in real output. The higher output causes the domestic price to increase. A money shock is not a main reason in increasing the domestic price because of its small and statistically insignificant effects. Vietnam’s current price-controlling regimes are effective in ensuring price stability in spite of shocks in world oil and rice prices.The outcomes of this research illustrate that the interest rate channel is the most effective channel for transmission to price fluctuations and the exchange rate for output variations. The study found the stock price channel as the least effective, which is consistent with the modest role of the stock market in the Vietnamese economy. This limits the statistically significant contemporaneous effects of monetary policy (the interest rate and credit) on stock prices. The monetary aggregate could not be a reliable tool to contemporaneously transmit monetary policy signals to the financial market.
Different approaches to modeling response styles in Divide-by-Total IRT models (Part I): A model integration
Authors: Henninger Mirka , Meiser Thorsten
Published: October 2022

A large variety of item response theory (IRT) modeling approaches aim at measuring and correcting for response styles in rating data. Here, we integrate response style models of the divide-by-total model family into one superordinate framework that parameterizes response styles as person-specific shifts in threshold parameters. This superordinate framework allows us to structure and compare existing approaches to modeling response styles and therewith makes model-implied restrictions explicit. With a simulation study, we show how the new framework allows us to assess consequences of violations of model assumptions and to compare response style estimates across different model parameterizations. The integrative framework of divide-by-total modeling approaches facilitates the correction for and examination of response styles. In addition to providing a superordinate framework for psychometric research, it gives guidance to applied researchers for model selection and specification in psychological assessment.
Development and Initial Validation of the in-Session Patient Affective Reactions Questionnaire (SPARQ) and the Rift In-Session Questionnaire (RISQ)
Authors: Stefana Alberto , Langfus Joshua A , Vieta Eduard , Fusar-Poli Paolo , Youngstrom Eric Arden
Published: October 2022

The patient’s perception of and reaction to the therapist (i.e., the transference) is theoretically and empirically associated with the psychotherapy process and outcome, regardless of the therapeutic approach. However, there are very few measures of transference, and the existing ones are observer- or clinician-report. The current project sought to develop and validate a short self-report inventory. We wrote a set of 131 items, examined the quality of the new measure using subject matter experts, and then collected validation data from a clinical sample of adult patients in individual therapy (N = 701). We used exploratory factor analyses and graded response model item response theory models to select items, confirmatory factor analyses to show that the factor structure fit the data well, and k-fold cross-validation to verify the robustness of our model. Three factors produced short scales retaining the strongest items. The Relationship In-Session Questionnaire (RISQ) has a two-factor structure, yielding a five-item Negative affect scale and a five-item Positive affect scale. The Assessing Risk of Relationship Rupture (ARRR) scale is made up of five items from the third factor with dichotomized responses; it should be used as a warning sign for ruptures in the patient-therapist relationship. Both scales showed excellent psychometric properties. Overall, this study provides an initial validation of both the RISQ and the ARRR scale that can be used in clinical or research settings, with particular value for capturing the patient’s perspectives about their therapist and session-level emotional processes.
Textile Poetics of Entanglements
Authors: Bardazzi Adele
Published: October 2022

By looking at the works of the poet Antonella Anedda (b. Rome, 1955) and the artist Maria Lai (Ulassi, 1919–Cardedu, 2013), this study investigates the relationship between poetic texts and textiles, contending that the ‘intra-action’ – to use the feminist physicist Karen Barad’s term – between the language of poetry and that of textile can be understood through a paradigm of entanglements that expands the semantic capacity of both words and textiles. One main objective of this study is to re-think the genre of lyric poetry and some of its core generic markers, in particular apostrophe, rhythm, and repetition, in light of a focus on materiality and tactility; this shall problematise ideas of linearity and completeness in favour of notions of movement, instability, and tactility. This will enable us to propose new parameters that allow for conceptualisation of textile poems and the textile poetics of entanglement that they articulate.
The Limits of Inclusion in Open Access: Accessible Access, Universal Design, and Open Educational Resources
Authors: Johnson Matthew Weirick , Abumeeiz Salma
Published: October 2022

Introduction: The impacts of open educational resources (OER) are both well-documented and far-reaching. Without mitigating the positive outcomes of OER—including reduced textbook costs, readily available knowledge platforms, and open research—we problematize the commonly held assumption that open resources are necessarily more accessible and inherently good. Description of Program: Drawing on writing from antiracist, feminist disability researchers and advocates, we critically examine the UCLA Library online open educational initiative known as Writing Instruction + Research Education (WI+RE). In doing so, we (1) demonstrate how open access (OA) is often framed as an end, when in fact it is just the beginning; (2) encourage readers to resist evangelizing the OA movement such that it is beyond critique; and (3) advocate for the centering of disability justice within and beyond our OA efforts. Next Steps: We discuss both general and specific approaches for centering accessibility in creative processes, advocate for expanded definitions of OERs (beyond simply being “free”), and caution against evangelizing OERs without acknowledging the structural factors that contribute to inaccessibility. We outline four strategies and recommendations for other practitioners, educators, and designers seeking to build accessibility and dis-ability justice into OER design and OA initiatives more broadly. We approach OER both practically and theoretically to present an argument and path forward for designing more accessible resources and expanding OA through accessible access and universal design.
CITTASLOW KENT MODELİ VE DOĞRUDAN DEMOKRASİ PRATİĞİ ÜZERİNE BİR ÖNERİ: CITTA-MODD (Cittaslow Mobil Doğrudan Demokrasi)
Authors: ALACA İsmet
Published: October 2022

Cittaslow, dünya genelinde kabul görmüş bir sürdürülebilir kent modelidir. 1999 yılında dört küçük ölçekli İtalyan belediyesi ile yola çıkan Cittaslow Belediyeler Birliği, 2021 yılı itibariyle 30 ülkede 278 üye kente erişmiştir. Hali hazırda Merkezi İtalya’da bulunan Cittaslow, kentlerin kendi kültürel kimlikleriyle var olabilmeleri adına bir farkındalık oluşturma çabasındadır. En az yarısı üyeliğin ilk aşamasında sağlanmak şartıyla 7 politika başlığı ve 72 kriterden oluşan bir kent modeli sunan cittaslow bu kriterlerin henüz hayata geçirilemeyenleri için ilgili kent yönetimlerine (muhatap alınan kurum belediyelerdir) esneklik tanımaktadır.

Yukarıda anılan Cittaslow kriterleri önemli ve gerekli olmakla birlikte, bu çalışmanın da konusunu oluşturan, “demokrasi” ve “demokratik katılımcılık”, başlıklarda yer almamakta, bağlayıcı olmayan muğlak ifadelerde demokrasi ve katılımcılık adeta temenni düzeyinde kalmaktadır. Oysa Cittaslow tabandan halk desteği ve halk iradesi ile sürdürülebilir bir kent modeli olma iddiasındadır. Yerel demokrasinin seçimden seçime yalnızca oy kullanmak ile sınırlandırılmaması, gerek Cittaslow kriterlerinin hayata geçirilmesi ve gerekse de kenti ilgilendiren tüm kararlarda halkın oyuna başvurulması elzemdir.

Bu çalışma “Cittaslow kriterleri, yerel demokrasi ve demokratik katılım bakımından yeterli midir?” sorusundan hareketle yazılmıştır. Çalışmanın hipotezi ise şöyledir: “cittaslow kentlerinin nüfusları düşük olduğundan dolayı gerek seçmen sayısının azlığı ve gerekse de teknoloji kullanımı konusunda cittaslow organizasyonunun ilkesel olumlu duruşu dolayısıyla, mobil telefonlar üzerinden doğrudan demokrasinin işletilmesine elverişlidir.” biçimindedir. Çalışma yalnızca bununla yetinmeyerek Citta-MODD (Cittaslow Mobil Doğrudan Demokrası) adıyla bir başlık ve alt kriter önerisinde bulunmaktadır.

Keza Uluslararası Cittaslow Birlik Tüzüğü’nün, Birlik’in kuruluşundan günümüze değin defalarca değişikliğe uğramış olması, onun ne denli dinamik bir yapıda olduğunu kanıtlar niteliktedir. Bu çalışma merkezine yavaşlık felsefesinin en gözde kurumlarından birini, Cittaslow’u almıştır. Cittaslow’un mevcut kriterlerine ilave olarak yerel demokrasi ve katılımcılığı öne çıkaracak yeni bir başlıkla öneride bulunmayı ummaktadır. Bu öneri, yavaşlık felsefesinin ruhuna uygun görülmektedir.
YEREL YÖNETİMLERİN TURİZM POLİTİKALARI ÜZERİNE BİR DEĞERLENDİRME: DOĞUBAYAZIT BELEDİYESİ ÖRNEĞİ
Authors: KÖSEDAĞ Erkan
Published: October 2022

Son yıllarda turizmde ülkenin tamamı yerine önemli destinasyonlarının ön plana çıkarılmasına yönelik çalışmalar yürütülmektedir. Bu sebeple yerel yönetimler turizmin ana unsuru olma yolunda ilerlemektedir. Kentin sosyal, ekonomik ve coğrafi yapısına hâkim olmaları dolayısıyla yerel yönetim denince akla ilk gelen kurum belediyelerdir. Belediyeler turizm politikalarını belirlemede önemli rol ve sorumluluk üstlenerek turizmi kentin kimliği üzerinden planlar. Ancak her belediye turizmde aynı başarıyı elde edemez. Çünkü yerelde yapılan tanıtımlar, yerel yöneticinin vizyonu, seçim vaatleri ve politikaları ölçüsünde gelişir ve uygulanır. Dolayısı ile belediye başkanlarının turizmine olan katkısı her kentte farklılıklar gösterir. Bu çalışma Türkiye’de belediyelerin turizm politikalarına nasıl katkıda bulunabileceğini tartışarak değerlendirmektedir. Makalenin merkezi ve yerel yönetim kurumlarının ulusal ve uluslararası ölçekte yapacağı çalışmalara veya üretecekleri tanıtım politikalarına sağlayacağı katkı açısından önemli olduğu umulmaktadır. Çalışma Ağrı ili Doğubayazıt Belediyesinin turizm politikaları ile sınırlandırılmıştır. Nitel araştırma yöntemine dayalı olarak gerçekleştirilen bu çalışmada; literatür taraması yapılmış, ulusal kurum ve kuruluşların raporları incelenerek veriler elde edilmiştir. Bu veriler, doküman analizi tekniği ile değerlendirilerek bulgulara ulaşılmıştır. Anket, mülakat, odak grup çalışması, gözlem, deney, görüşme teknikleri kullanılmadığından “Etik Kurul Raporu’na” ihtiyaç duyulmamıştır. Çalışma sonunda Doğubayazıt Belediyesi’nin turizm politikasının yeterli olmadığına ulaşılmış ve birtakım önerilere yer verilmiştir.
TUNAY ÖZER'İN ŞİİRLERİ ÜZERİNE BİR İNCELEME
Authors: GEÇER Köksal
Published: October 2022

Bu çalışmada yayımlanmış dört kitabı bulunan Tunay Özer’in bu kitaplarındaki şiirleri yapı, dil ve üslup, ağırlıklı olarak da içerik yönünden incelenmiştir. Bu inceleme ile şiirlerinin ana temaları, yapı, içerik ve üslup yönünden nitelikleri ve gelişim seyri belirlenmeye çalışılmıştır. Şairin hayat serüveni ve şiirlerinin yayımlanma sürecine dair bilgilere yer verilmiş, kullandığı dil ve semboller evreni açısından Türk şiiri geleneği ile kurduğu ilişkiye de değinilmiştir. Şiirlerinin tümünü serbest nazımla yazan şairin, çoğunlukla “hüzün, hatırlamalar ve hasret” üzerine bir içerikle okurlarının karşısına çıktığı belirlenmiş, şiirleri kitaplaştırılmadan önce ve hâlen çeşitli dergilerde yayımlanan şairin şiir serüveninde ilk kitabından son kitabına doğru içerik ve üslup yönünde sürekli bir gelişme olduğu gözlenmiştir.
Análise da eficácia de uma proposta Sociolinguística no ensino de pessoas com transtorno do espetro autista
Authors: Pereira da Rosa Aroldo
Published: October 2022

O objetivo dessa pesquisa é discutir sobre o ensino de gramática da língua portuguesa para pessoas com Transtorno do Espectro Autista (TEA). Segundo o DSM V (2014, p. 50), o Transtorno do Espectro Autista é um distúrbio neurológico que afeta a interação social, a linguagem e o processamento sensorial, e pode ser classificado como leve, moderado ou severo. Enquanto profissionais da educação, percebemos a dificuldade que professores encontram para trabalhar o ensino de língua em uma sala de aula com pessoas TEA, visto que o pensamento inflexível e as dificuldades de linguagem tornam esse processo mais difícil. Utilizando as bases da sociolinguística educacional e da pedagogia da variação linguística, nos debruçamos sobre uma proposta em específico: o ensino de gramática em três eixos (VIEIRA, 2017) – a fim de verificar a possibilidade ou não de aplicação dessa metodologia com pessoas TEA. As atividades serão preparadas levando em consideração suas dificuldades e habilidades.
A BNCC em perspectiva dialógica: focalizando a alteridade no discurso político-pedagógico contemporâneo
Authors: Brambila Guilherme
Published: October 2022

O presente artigo tem como objetivos discutir e problematizar como o discurso institucional da BNCC (Base Nacional Comum Curricular) se relaciona com a alteridade em seus posicionamentos sobre a educação brasileira. A partir da luz do pensamento bakhtiniano sobre a alteridade (BAKHTIN, 2011), alguns excertos da BNCC são utilizados em uma análise de base dialógica (BAKHTIN, 2010; SOBRAL; GIACOMELLI, 2016; MAGALHÃES; SILVA, 2016) e indiciária (GINZBURG, 1986), na busca por se entender que posições axiológicas percorrem o discurso institucional da BNCC ao lidar com a alteridade no contexto político-pedagógico brasileiro contemporâneo. Resultados da análise indicam a presença de pelo menos três eixos distintos que guiam a concepção de alteridade na BNCC e que refletem e refratam heranças históricas, culturais, sociais e discursivas que ainda são uma constante na formação identitária do brasileiro.
Inglês na primeira infância: educação bilíngue no Brasil
Authors: Martins Giovana Maria Carvalho , Lima Thereza Cristina de Souza
Published: October 2022

Este artigo objetiva discutir sobre a Educação Infantil e o bilinguismo no Brasil. O foco é o ensino de Inglês e escolas bilíngues brasileiras. Aborda a aquisição da Língua Inglesa na primeira infância, discutindo-se sobre o desenvolvimento infantil e a infância (EDWARDS; GANDINI; FORMAN, 2016; IVERSON, 2010), sobre o bilinguismo e as discussões acerca da aquisição da língua (MOZZILLO, 2015; VIAN JR; WEISSHEIMER; MARCELINO, 2013; MEGALE, 2005), sobre a criança bilíngue (MARTINS, 2007) e também sobre as escolas bilíngues e o bilinguismo no Brasil (FILIZOLA, 2019; MOURA, 2016). A metodologia utilizada foi a revisão bibliográfica, desenvolvendo-se a investigação por meio de análises e discussões de diversos autores. A temática da pesquisa partiu da experiência de uma das autoras com o ensino bilíngue na primeira infância, e da necessidade de desmistificar e entender a importância da aquisição de uma segunda língua na infância. Considerou-se a criança como agente ativo de seu aprendizado e como sujeito potente, e a língua como forma de expressão desta criança no contexto em que está inserida.
Uso de artigos definidos em redações escolares
Authors: Batista Hadinei Ribeiro
Published: October 2022

A presente pesquisa tem como foco o emprego de expressões nominais definidas (SNs definidos) em produções textuais de aprendizes da educação básica. O objetivo principal é tecer uma investigação quantitativa e qualitativa de SNs preenchidos com artigos definidos plurais e singulares com função referencial regular, frouxa (ou fraca) e genérica. A hipótese é que, independentemente da marcação de plural, os discentes optam normalmente por SNs definidos que operam em nível de referencialidade que varia entre fraca e genérica. A discussão em tese vem ao encontro da necessidade de um ‘olhar’ mais cuidadoso para os parâmetros da língua mais recorrentes nas produções dos educandos referentes aos domínios discursivos capazes de revelar variação semântica dessas expressões, decorrentes de escolhas linguísticas atreladas a essas diferentes funções dos artigos definidos.
Considerações dinâmicas acerca do desenvolvimento de línguas adicionais: uma análise de padrões de Voice Onset Time em Inglês-L2 e Francês-L3 produzidos por aprendizes brasileiros em contexto de instrução fonética
Authors: Castilhos Schereschewsky Laura , Kickhöfel Alves Ubiratã
Published: October 2022

À luz de uma visão de língua como um Sistema Dinâmico Complexo (VERSPOOR; DE BOT; LOWIE, 2011, entre outros), entende-se que mudanças em um subcomponente do sistema linguístico podem acarretar mudanças nos outros elementos e também no sistema como um todo. O presente estudo investiga as mudanças nos padrões de produção de Voice Onset Time do subsistema de Inglês-L2 e suas implicações no subsistema de Francês-L3 de cinco aprendizes brasileiros de Inglês-L2 e Francês-L3 como línguas adicionais. Esse estudo longitudinal foi conduzido no decorrer de 3 meses (12 pontos de coleta) e contou com uma intervenção de seis sessões de instrução fonética em Inglês-L2 entre as semanas 4 e 9. Análises de correlações móveis (moving correlations) (cf. VERSPOOR; VAN DIJK, 2011) em janelas móveis de 7 e 3 pontos trazem insumos empíricos acerca da inter-relação das línguas adicionais num contexto multilíngue.
Gramática contextualizada e letramento crítico: o uso dos adjetivos modalizadores no conto Lumbiá, de Conceição Evaristo
Authors: Lopes Gustavo Henrique Viana , Xavier Francisca Rebeca de Lima
Published: October 2022

Este estudo tem como objetivo propor uma atividade para o ensino dos adjetivos, especialmente dos adjetivos modalizadores, à luz da Gramática Contextualizada, destacando o papel dessa categoria na construção do gênero conto. Considerando que o adjetivo atribui uma propriedade singular ao elemento que é denominado pelo substantivo, conforme Neves (2018, p. 283), percebe-se a relevância dessa categoria gramatical não só para os contos, mas para quaisquer gêneros de sequência narrativa. A relevância deste estudo está no fato de que, ao considerar a função social da gramática, contribui-se para que os estudantes desenvolvam sua competência comunicativa bem como o letramento crítico, o que os levará a atuarem de forma mais eficiente na interação com os mais diversos textos nas mais diversas situações. Além disso, julgamos a abordagem proposta neste estudo mais coerente com o que preconizam os documentos oficiais relacionados à educação básica, como os Parâmetros Curriculares Nacionais (1997) e a Base Nacional Comum Curricular (2018). Assumindo a concepção de linguagem como interação, defendemos que a gramática não pode ser estudada fora dos contextos de uso, sendo objetos de análise as funções que cada uma das categorias gramaticais cumpre na construção dos sentidos do texto. Esta proposta se apoia, portanto, nos pressupostos funcionalistas, a partir dos quais se enxerga a língua como um fenômeno social, um instrumento de comunicação, adaptável às pressões oriundas das diversas situações de interação em que é usado.