bluuebunny/crossref_metadata_2025 huggingface dataset:
Determination of the Representative Socioeconomic Level by BSA in the Mexican Republic
Authors: Luquín-García María Dolores , Macedo Ruíz Edith Cecilia , Rojas-Altamirano Omar , López-Hernández Carlos
Published: January 2019

The aim of this article is to determine the socioeconomic level (SEL) with disaggregation of the Basic Statistical Area (BSA) in the Mexican Republic. The methodology used is the one established by the Mexican Association of Market Research Agencies (AMAI) along with the National Institute of Statistics and Geography (INEGI). The Clustering of the BSAs was carried out according to variables contained in the Population and Housing Census of 2010, through Gaussian mixture models, learning neural networks and finally, by defining the labels corresponding to each SEL. We found the existence of a representative SEL for each BSA. In addition, the definition of each socioeconomic level shows good results with an average of 90.86% of correctly labeled elements.
L’autonomia universitària i la governança
Authors: Moreso Jose Juan
Published: January 2019

Fa ja deu anys, en un estudi molt rellevant sobre les universitats europees, els autors Aghion et al. (2007) resumien en dos els factors que feien de les universitats europees insuficientment competitives: un finançament, públic i privat, insuficient i una governança ineficient. Aquest text aborda la segona qüestió. Més concretament, d’un aspecte, el jurídic, de la segona qüestió. La ubicació concreta de l’autonomia universitària a la Constitució espanyola de 1978 i la manera en què la jurisprudència constitucional ha entès aquesta ubicació representa entre nosaltres una dificultat afegida a l’hora de dissenyar el nostre futur. No es tracta d'un estudi per juristes sinó que es limita a explicar com la jurisprudència constitucional ha entès i quines mancances representa. Així mateix, es mostren les dificultats que aquesta doctrina comporta i algunes reflexions de futur.
Hàbits de consum cultural dels estudiants del grau de llengua i literatura catalanes a la Universitat de les Illes Balears. Presentació del projecte i resultats inicials
Authors: Picornell Mercè
Published: January 2019

Resum: Aquest article presenta un projecte de recerca per a la millora de la qualitat docent dut a terme a la Universitat de les Illes Balears durant el curs 2016-2017. Els objectius d'aquest projecte eren d'acumular i interpretar dades entorn dels hàbits de consum cultural i, específicament, literari, dels estudiants del grau de Llengua i Literatura Catalanes. En primer lloc, l'article exposa la reflexió sobre la funció de l'ensenyament de la literatura en l'educació superior que motiva aquesta anàlisi. En segon lloc, s'explica el procediment amb què es va dur a terme la investigació. Finalment, s'expliquen algunes de les conclusions preliminars a les quals s'ha arribat en la fase inicial d'un estudi que caldrà completar en el futur amb una anàlisi longitudinal y mitjançant la recollida de més dades.
Aplicación del Blogging y/o Google Docs para fomentar la competencia en producción escrita en la enseñanza del inglés
Authors: Montaner-Villalba Salvador
Published: January 2019

En la actualidad, el uso de las TIC en el aula de idiomas y, en concreto, en la enseñanza de la lengua inglesa ha aumentado notablemente a causa de las diversas posibilidades que éstas ofrecen en la educación, con el único fin de motivar al alumnado durante todo el proceso de aprendizaje.En el presente trabajo, se pretende como objetivo principal verificar y/o corroborar si, al final de la experimentación educativa, los alumnos han mejorado su competencia en producción escrita en lengua inglesa mediante el Blogging con el uso de la plataforma Wordpress (https://wordpress.com) y mediante el uso del Google Docs.Mediante la experimentación correspondiente, los alumnos también desarrollan otras competencias, tales como la competencia digital y la competencia “aprender a aprender”, teniendo en mente que el uso de las TIC en la enseñanza de lenguas extranjeras aporta grandes beneficios en el proceso de aprendizaje, a modo de ejemplo, la adquisición de mayor autonomía por parte del alumnado.
Uso de las redes sociales virtuales por los estudiantes de la UAT
Authors: Leal Rìos Fernando , García Leal María , Estrada Bellman Pedro Carlos , Cabero Almenara Julio
Published: January 2019

Las redes sociales virtuales son las herramientas más representativas del cambio sustancial en la humanidad, además implican una oportunidad importante para generar puentes de comunicación más amigables entre estudiantes, profesores y otros actores relacionados con el ámbito educativo. El objetivo del trabajo fue conocer los hábitos de comunicación en las redes sociales virtuales por estudiantes de la Universidad Autónoma de Tamaulipas. La metodología utilizada fue socio-empírica, de tipo transversal y cuantitativa, la muestra estuvo conformada por 250 alumnos de nivel licenciatura de diferentes programas educativos que se imparten en la Universidad Autónoma de Tamaulipas. Los resultados encontrados indican que fue un 33 % de mujeres las que cumplimentaron el cuestionario, el rango de edad de los participantes oscila entre los 18-24 años, los encuestados mencionan que el 40 % de los contenidos que comparten en redes sociales son tareas. Así mismo el 26 % y el 40 % de los alumnos indican que el horario de la mañana y por la noche es en el que usan con más frecuencia las redes sociales, respectivamente. A manera de conclusión se encontró que la red social Facebook, así como el servicio de mensajería instantánea WhatsApp son utilizadas con mayor frecuencia por los estudiantes, así como el uso del celular es el dispositivo más utilizado por los estudiantes en el momento de conectarse.
Editorial
Authors: Palau Martín Ramón , Gisbert Cervera Mercè
Published: January 2019

En aquest número de la revista presentem un conjunt d’articles de temàtiques molt variades però amb l’eix comú de ser investigacions sobre com el coneixement dels hàbits de consum de la cultura, usos de les xarxes socials i la tecnologia poden permetre als docents dissenyar processos d’ensenyamentaprenentatge per a l’adquisició de les competències del segle XXI.
Ciência e Tecnologia na Sociedade Digital: Visão de alunos do Curso de Licenciatura em Química
Authors: Oliveira Micheline Soares Costa , Costa Michelle Maytre Mota da , Cavalcante Thaís Rocha
Published: January 2019

O trabalho foi realizado com os estudantes do Curso de Química da Universidade Estadual do Ceará, na disciplina de Ciência, Tecnologia e Sociedade. Foram entrevistados dezesseis alunos. Eles responderam a um questionário elaborado pelo Projeto Iberoamericano de Evaluación de Actitudes Relacionadas con la Ciencia, la Tecnología y la Sociedad (PIEARCTS). Este projeto foi aplicado em países da América do Sul como Brasil, Colômbia, Argentina e Venezuela; como também Portugal e Espanha. Os resultados das questões F1-20141 e F1-20411 foram semelhantes aos obtidos em pesquisa realizada no Centro Federal de Educação Tecnológica Celso Suckow da Fonseca - Rio de Janeiro em dezembro de 2010. Além dessas questões utilizou-se, do referido questionário, as questões F1-40161, F1-40221 e F1-40531 que tratam da Influência da Ciência e Tecnologia na Sociedade. Os resultados mostraram que após as intervenções didáticas, os respondentes se mostraram atualizados com os efeitos da tecnologia no mundo social e acreditam que o avanço tecnológico pode melhorar a qualidade de vida, quando utilizados com discernimento.
Minimally invasive surgical treatment of a patient with pathological tortuosity of the carotid artery using endoscopic assistance
Authors: Lukyanchikov V. A. , Khasauov R. Kh. , Kozhaev Z. U. , Gekkieva Zh. S. , Krylov V. V. , Vinogradov R. A.
Published: January 2019

The study objective is to describe a clinical case of surgical treatment of a patient with pathological distal tortuosity of the left internal carotid artery (ICA) and present a comprehensive description of a proposed surgical technique, as well as compare advantages and disadvantages of the chosen and alternative surgery types.

Materials and methods. At the 1st stage, we performed computed angiography and triplex scanning of the main head arteries and modelled operative approach. At the 2nd stage, we mapped the ICA approach, redressing and resection. At the 3rd stage, using endoscopic assistance we separated the ICA along its entire length, found its pathological kink, performed ICA redressing and resection with subsequent reanastomosis with high accuracy and minimal injury.

Results. ICAblood flow was 320 ml/min (prior to surgery: 140 ml/min). In the postoperative period, positive dynamics of the patient’s neurological status were observed. Computed angiography and triplex scanning confirmed removal of pathological tortuosity. Compared to the proposed technique, other surgery types (open access) are characterized by high risk of injury of the cranial nerve branches, submandibular and parotid glands, necessity of dissection of the digastric, stylohyoid muscles, subluxation of the mandibula, etc.

Conclusion. The method of allocation of hard to reach tortuosities of the carotid artery developed based on previously known endoscopic manipulations on the vessels of the extremities using endoscopic assistance allows to decrease injury during the intervention and achieve maximal technical and clinical effect.
At the junction of disciplines: neurogenic bladder in patients with traumatic spinal cord injury
Authors: Korshunova E. S. , Korshunov M. N. , Darenkov S. P.
Published: January 2019

The recommendations on the diagnosis of urinary disorders (developed by the International Continence Society and the European Association of Urology) are presented. The effectiveness of drug treatment and catheterization in patients with traumatic spinal cord injury and neurogenic bladder, as well as contraindications to catheterization and the frequency of complications were analyzed. Intermittent catheterization, by the trials’ data, it seems the preferred method of treatment. Different types of urethral catheters are described. There are 3 methods of intermittent catheterization, as well as the basic principles of its implementation on the recommendations of the European Association of Urology. Emphasized that only the cooperation of specialists in the interdisciplinary team creates the conditions for the optimal management of neurogenic bladder that is able to bring the life expectancy of people with traumatic disease of the spinal cord to the indicators in the general population.
The necessity and advantages of personified neck lymph node dissection in T1-2N0M0 oral mucosa cancer. A pathway to radical surgery
Authors: Margolin G. , Mudunov A. М. , Gelfand I. M. , Alymov Yu. V. , Akhundov A. A. , Podvyaznikov S. О. , Narimanov M. N. , Zabotina T. N. , Zakharova E. N.
Published: January 2019

The study objectiveis to investigate the causes of insufficient efficiency of neck lymph node dissection and possibilities of its improvement in cancer of the oral mucosa without clinically detectable metastases.

Materials and methods.A review of literature on surgical methods of affecting regional lymph collectors in cancers of the oral cavity was performed, and preliminary data on possibilities of biopsy of the sentinel lymph node were obtained.

Conclusion.Combination of fluorescent lymph node mapping andflow cytometry allows to identify the sentinel lymph node and detect hidden micrometastases with high sensitivity.
Prevalence of virus-associated cancer of the nasal cavity and paranasal sinuses in the Arkhangelsk Region
Authors: Vereschagin M. Yu. , Minkin A. U. , Makarova M. V.
Published: January 2019

The study objective is to evaluate the prevalence of Epstein—Barr virus (EBV), herpes virus, human papillomavirus (HPV), and cytomegalovirus (CMV) infection among patients with cancer of the nasal cavity and paranasal sinuses in the Arkhangelsk Region.

Materials and methods. We examined surgical specimens from 100 patients treated in the Arkhangelsk Clinical Oncology Dispensary between 2010 and 2015. Tissue homogenates were used for DNA isolation. DNA amplification with subsequent detection was performed using polymerase chain reaction.

Results and conclusion. The 36 % of study participants were infected with EBV; the second most common viral pathogens were CMV and human herpes virus type 6 (HHV-6), both found in 21 % of cases. Monoinfection was observed in less than one-third of patients (20 % — EBV, HPV type 16 — 6 %), whereas the remaining participants had mixed infections: EBV + HHV-6 (2 %), CMV + EBV (5 %), EBV + herpes simplex virus types 1 and 2 (HSV-1,2) (1 %), EBV + CMV + HHV-6 (3 %), HPV type 16 + HSV-1,2 (3 %), and HPV type 6 + HPV type 16 (7 %). None of the patients with stage I cancer had mixed infections, whereas participants with stage II, III, and IV cancer demonstrated mixed infections in 1 %, 11 %, and 9 % of cases respectively.

After specific treatment, 11 patients (30.5 %) infected with EBV developed regional metastases and 5 patients (13.9 %) had relapses. All patients simultaneously infected with EBV and HHV-6 had distant metastases. Combination of EBV, CMV, and HHV-6 resulted in relapses in 100 % of cases and distant metastasis in 75 % of cases.
European consensus for starting and stopping enzyme replacement therapy in adult patients with Pompe disease: a 10-year experience
Authors: Van der Ploeg A. T. , Kruijshaar M. Ую , Toscano A. , Laforet P. , Angelini C. , Lachmann R. H. , Pascual Pascual S. I. , Roberts M. , Rosler K. , Stulnig T. , Van Doorn P. A. , Van den Bergh P.Y. K. , Vissing J. , Schoser B.
Published: January 2019

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THE NEO-IMPERIALISM OF MODERN RUSSIA AS A HISTORICAL CHALLENGE FOR UKRAINIAN POST-COLONIAL ELITS
Authors: Grabovska Irina
Published: January 2019

The article analyzes the policy and practice of neo-imperialism in the Russian Federation, examines the specificity of Putinizm as a historical challenge posed by the post-Soviet post-colonial elites of the former USSR, in this case, the Ukrainian ones. Existing certain toleration of the culture of the colonizer, inherent in a large number of representatives of the Ukrainian elites, both political, and economic and creative, is one of the hallmarks of their unshakable post-colonialism, which, in turn, hinders the transformation of Ukraine into a modern European civilized state and a full-fledged modern nation. The need for a more determined opposition to the political and ideological influences of the modern Kremlin, its neo-imperial actions, theprovision of more effective and tougher resistance to the aggressor-Putin's Russia, which invaded Ukraine and imposed a hybrid war on its people, is not only a requirement that is relevant to self-preservation and consolidation Ukrainian independent nation, but also a persistent advice from the politicians of different countries who are committed to Ukraine and advanced analysts from the present-day Russia. Moreover, the real history of post-Soviet Ukraine and the post-Soviet Russia is a confirmation of the differences, including ideological, between the two peoples. At a time when post-colonial Ukraine was looking for itself in the labyrinths of many, and especially of the two-vectored, having finally ended on the road to a common European home, Russia tried to become democratic, but its efforts in this direction ended in defeat. Some of the contemporary Russian philosophers generally argue that the post-Soviet period in Russia went on an effort to return to the USSR. The Russian post-Soviet postcolonial period tried to get rid of their own "humiliation" and "to rise from their knees". A number of contemporary Russian intellectuals even argues that raising the people from their knees is the only real merit of the President of the Russian Federation VV. Putin before the Russian people. For example, the president of Lithuania Dalia Grybauskaitė has repeatedly expressed the opinion that Ukraine should take a much more resolute stand against the policies and actions of Putin's Russia. The ability to effectively confront an insidious aggressor - Putin's Russia - has become an exam today for Ukrainian elites regarding their viability and effectiveness.
CREATIVE HERITAGE OF CHURCH HIERARCHS OF THE UKRAINE OF THE EARLY MODERN TIME AS CONSOLIDATING FACTOR OF UKRAINIAN ORTHODOXY (ON MATERIALS OF LITURGICAL AND HAGIOGRAPHIC WORKS)
Authors: Kagamlyk Svitlana
Published: January 2019

Ukrainian hierarchs of the early modern age left behind a rich creative heritage, which comprised various works by volume, genre and theme. Their analysis demonstrates the multifaceted interests of their authors, which turned out to be diverse in scope, genre and subject works. First of all, they were liturgical and polemical works, which put the actual issues of theological, dogmatic and ritual nature, that arose in the process of inter-confessional polemics. Important hagiographic works, that raised the authority of Ukrainian Orthodoxy, belonged to Ukrainian ecclesiastical writers-bishops. In addition, their works included works of a secular nature - historical, poetic, dramatic, autobiographical works, study guides, works on moral and ethical subjects. This testifies that their creators in their educational and ideological settings went far beyond their spiritual state. The purpose of this article is an attempt to analyze the creative heritage of the Ukrainian bishops of the early modern age, in particular the works, which served as the consolidating factor of Ukrainian Orthodoxy - liturgical and hagiographic works. It is concluded, that theological and hagiographic works of church hierarchs were an important consolidating factor of Ukrainian Orthodoxy. They performed an important mission of purposeful popularization of the Ukrainian, mainly Kyiv, shrines and elevating the authority of Ukrainian Orthodoxy. The fundamental liturgical works, that were necessary to overcome the crisis of Ukrainian Orthodoxy, were created from the initiative and personal participation of Peter Mohyla in the circle of the leaders of the Pechersk cultural and educational circle, he headed out. The release of the four-volume hagiographic encyclopedia of Demetrius Tuptala ("The Life of the Saints") became the highest outgrowth of hagiographic writing in Ukraine and made, as so as the Patericon of Sylvester of Kosovo, a great influence on the development of literary monuments of that time. The popularity of the liturgical and hagiographic works of the main theorists of the Ukrainian Orthodoxy has been witnessed by their widespread dissemination and use among various Christian denominations.
UKRAINIAN CHURCH ELITE IN FORMATION OF MUSICAL CENTERS UNDER SPIRITUAL EDUCATIONAL INSTITUTIONS OF HETMANATE
Authors: Tregubenko Tetiana
Published: January 2019

For a long time, the creative heritage of many singers and composers of the seventeenth and eighteenth centuries, which was created at Hetman residences, churches and monasteries remained insufficiently explored, and partly unknown. In recent decades a number of works by domestic musicologists have been published, which largely filled this gap. Works mainly concern secular music or some of the most well-known composers who wrote spiritual music. At the same time, the scope of the activities of the church musical centers remains unexplored to modern days, as are the names of many of their representatives from the monastic structure. In this article was made the attempt to find out the role of the Ukrainian church elite in formation of the musical centers of Hetmanate, as well as to reconstruct their personnel on the basis of the analysis of newly discovered archival documents and various publications. It was noted that the specifics of the formation of these musical centers was that they focused on contemporary spiritual educational institutions that were preparing the frames of composers and performers. The leading of them was the Kyiv-Mohyla Academy, which for a long period of time was the main "staff of personnel" of the time composers of spiritual music and performers of choral church singing. The organizers of the musical life at the Academy were first of all its rectors, who opened the music classes, organized student choirs and wrote musical works for them. A separate subject, which was studied at the Academy, was Kant's singing, the formation of which was facilitated by the new Paretza system of choral performance. Musical centers in Chernihiv, Kharkiv and Pereyaslav focused on collegiums initiated by local bishops and completely dependent on their personal interest. It is concluded that the majority of diocesan bishops actively promoted the development of musical education in their eparchies, some of them became founders of choral groups and authors of musical works. The Chernihiv cell, initiated by Archbishop Lazar Baranovich more than half a century earlier from Kharkiv and Pereyaslavsky, benefited from the activity of his own printing press, which published various musical works, which ensured the progress of musical art in Chernihiv region and the entire Left Bank Ukraine.
CEREBRAL PERFUSION AND CIRCULATION DISTURBANCES. PART III (NON-CONTAST METHODS, RATIONALE AND SAFETY): A REVIEW
Authors: Semenov S. E. , Milinevskiy N. I. , Korotkevich A. A. , Portnov Yu. M. , Semenov A. S.
Published: January 2019

The third part of the review article provides new insights into tissue / cell brain perfusion in chronic cerebral vascular insuffciency, commonly accompanied by polyvascular disease, i.e. stenotic and occlusive lesions of the carotid and coronary arteries. The evaluation of regional cerebral blood ﬂow and cerebrovascular reactivity in the preoperative period of revascularization procedures remains an issue of concern for radiologists. Partly the choice of revascularization strategy, staged or simultaneous revascularization of the carotid and coronary arteries, depends on these parameters. Contrast-enhanced perfusion magnetic resonance imaging (MRI) and computed tomography perfusion (CTP) are commonly associated with a rather high risk of adverse reactions, compared to the widespread single-photon emission computed tomography (SPECT) and arterial spin labelling (ASL) MR perfusion technique, rapidly growing in the last decade. Clinical studies and the introduction of radionuclide diagnostics (SPECT) and non-contrast MR methods (ASL) into routine clinical practice will minimize these risks, while providing clinicians with accurate information on the capacity and cerebral blood ﬂow reserve, which play signifcant role in determining the treatment strategy, similar to the capacity and myocardial blood ﬂow reserve.
CLINICAL PATTERNS OF VASOSPASTIC ANGINA
Authors: Ulbasheva E. A. , Namitokov A. M. , Kandinsky M. V. , Kosmacheva E. D.
Published: January 2019

Vasospastic angina (angina inversa, variant angina or Prinzmetal angina) is a rare variant of the course of coronary artery disease. Despite a good understanding of its underlying mechanisms (prolonged coronary spasm resulting from endothelial dysfunction) and contributing factors (smoking, exposure to cold weather, cocaine, autoimmune diseases, etc.), the treatment of each individual patient remains a source of discussion. To date, these patients are commonly treated with drugs, especially calcium antagonists and nitrates. The article presents clinical cases of patients with vasospastic angina and discusses their treatment depending on the individual clinical pattern. Early diagnosis of vasospastic angina allows preventing in some cases fatal complications and save patients’ life.
INTERNATIONAL EPIDEMIOLOGICAL STUDY OF NONCOMMUNICABLE DISEASES IN RUSSIA: PROTOCOL
Authors: Barbarash O. L. , Artamonova G. V. , Indukaeva E. V. , Maksimov S. A.
Published: January 2019

The article presents the general description of the epidemiological study program in the Kemerovo region in accordance with the protocol, methodical approaches to sampling, characteristics of the questionnaires for collecting the detailed information, as well as instrumental and laboratory research methods. The study program in the Kemerovo region is based on the unifed principles of an international study, which provides four stages: preparatory stage, screening, assessment of morbidity/mortality (follow-up period), survival status assessment and work with the study database. Prospective observation with assessment of fatal and nonfatal endpoints is performed once in three years, starting from the next year after the completion of the frst stage of the study. The phase of participants’ involvement includes performing of the doorto-door visits – more than 6000 households, among which there were 5660 urban and 460 rural households. The study is planned to involve 1600 participants. The participants will be fully examined according to the protocol: ECG (interpretation by Minnesota code), spirometry, anthropometry, dynamometry, bioimpedansometry, measuring of arterial blood pressure and heart rate; blood test – total cholesterol, HDL, LDL, triglycerides, plasma glucose; uranalysis – creatinine, sodium, potassium. Data collection will be performed at three levels (community, household and individual). These levels include 4 social determinants (artifcial environment, diet, tobacco use, socioeconomic/psychosocial determinants). The obtained information will be entered into the database with its subsequent statistical processing. It is planned to perform follow-up examinations of the participants within three years in order to record the clinical events. Additional data on diet, physical activity, blood tests and ECG will be collected in all the participants. The newly received data will be entered into the database and statistically processed. Within the study, for the frst time the mutual inﬂuence of social, family, individual and genetic determinants of non-communicable diseases will be studied depending on the residence place, which will allow to estimate the effcacy of state and regional healthcare policy, to develop and implement into the medical practice new individual and population prevention programs which contribute to the implementation of the program for mortality reduction from cardiovascular diseases, improvement of the quality of life and prognosis.
ANALYSIS OF SPONTANEOUS REPORTS OF ADVERSE REACTIONS IN PATIENTS WITH CORONARY ARTERY DISEASE IN THE REPUBLIC OF CRIMEA
Authors: Matveev O. V. , Krasheninnikov A. E. , Kiseleva N. M. , Egorova E. A. , Dormidor A. G.
Published: January 2019

Aim. To analyze spontaneous reports of adverse drug reactions in patients with coronary artery disease in the Republic of Crimea for the fve-year period from January 2011 to August 2016.

Methods. 332 reports of adverse drug reactions in patients with coronary artery disease collected in the “ARCADe” database were analyzed. Out of them, 231 reports on essential drugs affecting the cardiovascular system were selected. The age of patients who reported adverse drug reactions ranged from 37 to 90 years.

Results. The rate of adverse drug reaction reports increased with patients’ aging, reaching its maximum (31.6% of all drug reaction reports) by 70–80 years. The incidence of adverse reactions was higher among women (63.6%), which is generally consistent with other studies. However, men receiving nitrates had a 3.4-fold increase in the rate of adverse drug reactions compared to women. The highest rate of adverse drug reactions was associated with ACE inhibitors (29.0%), and in particular Enalapril, which is probably explained by a higher rate of their prescriptions, compared to other drugs.

Conclusion. Most of the reported adverse drug reactions were expected. The frequent development of allergic reactions (16% out of all adverse reactions in this study) in patients with coronary artery disease were associated with ACE inhibitors, betablockers and antithrombotic agents.
Regarding the subject of degradation of femoral medial condyle cartilaginous tissue in damaged knee joint medial meniscus
Authors: Denisov A. S. , Zagorak D. P.
Published: January 2019

Aim. To reveal the influence of patient’s connective tissue state and body mass on the development of damage of the cartilaginous tissue of femoral bone medial condyle in case of medial meniscus rupture.

Materials and methods. The study included 85 patients, undergoing arthroscopic treatment of the knee joint in connection with damaged medial meniscus. The damage degree of femoral medial condyle cartilaginous tissue was estimated using Outerbridge classification (1961). The body mass was calculated by the body mass index kg/m2. To assess the connective tissue elasticity, “the method of express diagnosis of dysplastic state of connective-tissue structures in conditions of ambulatory traumatologo-orthopedic service” was used.

Results. The present paper is devoted to a widespread problem – the damage of femoral medial condyle cartilaginous tissue in case of medial meniscus rupture. The aim of the study was to find out the influence of connective tissue state and body mass on the damage of the femoral medial condyle cartilaginous tissue. Seventy patients were examined. As a result of analysis, it was established that an excess body mass as well as low connective tissue elasticity provoke destruction of the cartilaginous tissue of femoral bone medial condyle. Patients with connective tissue dysplasia are more tolerant to cartilaginous tissue degradation. The risk group for cartilaginous tissue damage includes persons with low connective tissue elasticity and obesity.

Conclusions. When medial meniscus is ruptured, most patients during the first 6 months after trauma experience damage of femoral medial condyle cartilaginous tissue. The most favorable for the outcome is the state when patients have a normal body mass. Dysplastic state of connective tissue somehow eliminates the damaging factor at the expense of elevated elasticity of cartilaginous tissue. The most unfavorable is the situation, when patients have excess body mass and low connective tissue elasticity. For this group of patients the most optimal variant is hospitalization and arthroscopic treatment taking into account urgent indications.
Changed content of heat shock proteins and antibodies to them in blood and nasal mucosa cells in rhinites and rhinosinusites of different etiology
Authors: Ivanov M. O. , Ivanova N. M. , Maksimenya M. V. , Karavaeva T. M. , Egorova E. V. , Fefelova E. V. , Tsybikov N. N.
Published: January 2019

Aim. To determine the content of heat shock proteins with molecular weight 70 kDa (HSP 70) and antibo dies to them in blood and nasal secretion in patients with allergic rhinites and infectious rhinosinusites of different etiology.

Materials and methods. The paper presents the results of examination of 10 patients with allergic rhinitis and 30 patients, infected with rhinosinusites(the age range 25–35 years). The patients with infectious rhinosinusites were divided into 3 groups according to nosologic form of disease. The control group included 10 practically healthy persons in the ratio, comparable by their gender and age with sick persons.

Results.The analysis showed that in the nasal secretion of all patients, HSP 70 level significantly raised compared to the control. Maximum values were registered in patients with bacterial rhinosinusitis and were higher than in patients with viral and fungous ones by 1.9 times (p = 0.015) and 2.9 times (p = 0.001), respectively. In blood serum, HSP 70 concentration compared with the control increased in patients with allergic rhinitis and bacterial rhinosinusitis by 103.67 % (p = 0.015) and 32.11 % (p = 0.049), respectively; these values in the last two groups exceeded the latter in patients with fungous RS by 2.37 times (p = 0.01) and by 1.54 times (p = 0.035).

Conclusions. It was detected that in the group of patients with allergic rhinitis and chronic bacterial rhinosinusitis in the nasal secretion and blood serum, HSP 70 values were the highest. In the nasal secretion, HSP 70 level was higher than in blood. The amount of autoantibodies to HSP 70 in blood grew in allergic rhinitis, fungous and viral forms of rhinosinusites that reflects the immunological effect of chaperone proteins.
Characteristics of adaptive responses and status of newborns depending on degree of parturient genital colonization with Ur. Urealyticum
Authors: Melnikova T. A. , Padrul M. M. , Gorovits E. S. , Rabotnikova G. I.
Published: January 2019

Aim. To study the characteristic features of newborn status depending on the level of parturient genital colonization with Ur. urealyticum.

Materials and methods. The characteristic features of newborns’ status were studied in 112 puerperas, who by the results of repeated microbiological examination for ureaplasmosis, in the period of 30–34 weeks of pregnancy were divided into 3 groups: group I included 38 persons with negative results of PCR and bacteriology; group II (risk) joined 39 women, infected with Ur. urealyticum to 104 CFU/ml and PCR 5·104 DNA copies per ml; and group III – 35 pregnant women with bacterial inoculation less than 104 CFU/ml. The comparison group – 40 pregnant women, uninfected with ureaplasmas when examined for the first time.

Results. In newborn children from puerperas of risk group, Apgar scores at 1 and 5 minutes were statistically significantly lower, than in children, born from mothers of the other groups. In this group, birth of premature newborns and those with hypotrophy as well as newborns with fetal development retardation syndrome were registered significantly more often. Perinatal encephalopathy was detected in 50.0 % of newborns. When discharged from maternal home, nearly a half of infants from this group had no the initially required body mass, but in the other groups there were 2–2.5 times more such newborns.

Conclusions. Newborns from mothers infected with Ur. Urealyticum in high, etiologically significant titers, are characterized by decrease in adaptive responses that is proved by Apgar scores and by retarded body mass growth after birth. High level of parturient genital colonization with Ur. urealyticum has a negative effect on the newborns’ health status. Low, etiologically insignificant Ur. urealyticum titers in mothers practically don’t influence the newborns’ health status.
Cerebral amyloid angiopathy, associated with inflammation: clinical observation and literature review
Authors: Kulesh A. A. , Gorst N. Kh. , Drobakha V. E. , Kaileva N. A. , Bykova A. Yu. , Shestakov V. V.
Published: January 2019

Cerebral amyloid angiopathy, associated with inflammation (CAA-I) is a rare syndrome, described rather long ago. The course of disease varies from conditionally asymptomatic, very seldom diagnosed forms to severe lethal cases with intracerebral bleedings and brain edema. The basic clinical symptoms of CAA-I are cognitive disorders, convulsions, headache, consciousness impairment, often ignored or wrong interpreted. Manifestations of CAA-I are a part of clinicoradiological continuum, significantly influencing the course of other cerebrovascular diseases. The paper presents description of a clinical case of symptom-free or preclinical form of CAA-I, incidentally detected while realizing magnetic resonance tomography. Analysis of this clinical case and literature data demonstrates difficulties of CAA-I differential diagnosis, value of neurovisualization in patients with cognitive disorders and accentuates the need of expanding the existing diagnostic criteria of CAA-I.
Influence of polychemotherapy on cognitive functions in patients with lymphoproliferative diseases: literature review and personal clinical observations
Authors: Teregulova D. R. , Bakirov B. A. , Akhmadeeva L. R.
Published: January 2019

The factors, influencing the development of cognitive defects in patients after chemotherapy are the following: personal individual intellectual and genetic characteristics, immune dysfunction and neurotoxicity. Cognitive domains, disturbed to a greater extent, are memory, attention, thinking rate and executive functions. Sixty one patients, diagnosed lymphoproliferative disease, (chronic lympholeukosis – 28 persons, multiple myeloma – 33) were examined; patients’ mean age was 63.87 ± 9.76 years. Reduced cognitive function was revealed in 73.77 % of patients, a mean score by MoCA scale was 22.87 ± 4.08. Cognitive defects negatively influence patients’ quality of life, significantly reduce their physical and mental working ability, everyday activity, make execution of professional duties difficult, besides they can complicate nursing.
The 80th anniversary of the department of therapeutic stomatology and propedeutics of dental diseases
Authors: Gileva O. S. , Zadorina I. I. , Sivak E. Yu. , Libik T. V. , Korotin S. V. , Syuzeva D. V.
Published: January 2019

The paper deals with historical information on the formation and development of the Department of Therapeutic Stomatology of Academician Ye. A Vagner Perm State Medical University – “Alma-mater” for several generations of dentists. It is the history not only in figures and factors but regards people, who contributed to the development of native stomatology in the Ural region.
Hatay İlinin Portakal Üretimi ve Dış Ticarette İşletmelerin Pazarlama Stratejileri
Authors: KIZILTUĞ Tuğçe , FİDAN Halil
Published: January 2019

Bu araştırmanın amacı, Hatay ilinde portakal
ihracatı yapan işletmelerin uluslararası pazarlarda uyguladıkları stratejilerin
belirlenmesi ve ihracatta yaşanılan sorunların değerlendirilmesine yöneliktir.
Çalışmada, kullanılan anketler yüz yüze görüşme yoluyla işletmelere uygulanmış
olup, 41 işletme yetkilileri ile görüşülmüş ve elde edilen veriler, 2014-2015
dönemini kapsamaktadır. Anket sonuçlarına göre; işletmeler farklılaştırılmış
pazarlama stratejisini benimsemiş oldukları, dış pazarlardaki fiyatlandırmanın
piyasa fiyatlarına göre yapıldığı, dış pazarlarda ürün kalitesi rekabet
edilebilirliği artırdığı belirlenmiştir. Portakal ihraç eden işletmelerin
yöneldiği en önemli pazarlar Rusya ve Ortadoğu ülkeleridir. Ayrıca bu
işletmeler yeni pazarlara yönelmek yerine mevcut pazarlarını korumak
istemektedirler. Fakat mevcut pazarlarını korumak adına tutundurma
faaliyetlerine ve Ar-Ge çalışmalarına da yeterince önem vermemektedirler.
Ayrıca işletmelerin, taşıma, ambalajlama, depolama gibi problemlerden dolayı
%10-15 oranında ürün kaybı yaşadıkları anlaşılmaktadır. Bu nedenle, bu ürünleri
imha etmekte ya da daha az seçici ülkelere göndermeyi tercih etmektedirler.
İşletmelerin denizyolu taşımacılığında ciddi sıkıntılar yaşadıkları ve devlet
kuruluşlarınca ihracatın desteklenmesi konusunda bir beklenti içinde oldukları
saptanmıştır.
Kermes Meşesi [Quercus coccifera (L.)] Yaprak Ekstraktının Tetranychus urticae Koch, Callosobruchus maculatus F. ve Plodia interpunctella (Hubner)’ya Toksik Etkileri
Authors: ÇETİN Hüseyin , ELMA Fatma Nur
Published: January 2019

toksik etkileri araştırılmıştır. T.
urticae ve C. maculatus’un
erginleri, P. interpunctella’nın ise
3- 4. dönem larvaları denemelerde kullanılmıştır. Yaprak ekstraktının (% 20, %
10, % 5, % 2.5 ve % 1.25 (w/w)) beş farklı konsantrasyonu kullanılmıştır.
Denemeler 28±1°C sıcaklık, % 65±5 orantılı nem (T. urticae için 16 saat aydınlatma süresi) koşullarında
yürütülmüştür. Denemeler 3 tekerrürlü olarak yürütülmüştür. Sayımlar
uygulamadan 24 ve 48 saat sonra yapılmış ve ölü ve canlı bireyler
kaydedilmiştir. T. urticae’ de bitki
ekstraktının oldukça etkili olduğu ve uygulamadan 48 saat sonra % 10’lik
konsantrasyonda % 98 oranında ölüm meydana getirdiği görülmüştür. C. maculatus’ta en yüksek ölüm oranı %
20’lik ekstrakt konsantrasyonunda ve 48 saat sonunda % 96 olarak
belirlenmiştir. Q. coccifera yaprak
ekstraktının P. interpunctella
larvalarına toksik etkisinin düşük olduğu belirlenmiştir.(Hubner)
(Lepidoptera: Pyralidae)’ya Bu çalışmada, Kermes
meşesi, Quercus coccifera (L.)
yapraklarından elde edilen ekstraktın kültür bitkilerinin önemli
zararlılarından Pamuk kırmızıörümceği, Tetranychus urticae Koch (Acarina: Tetranychidae), depolanmış
ürün zararlılarından Börülce tohumböceği, Callosobruchus
maculatus F. (Coleoptera: Chrysomelidae) ve Kuru meyve güvesi, Plodia interpunctella
Effects of Mating Disruption Method on Predators Chrysoperla carnea (Stephens, 1836) (Neuroptera:Chrysopidae) and Coccinella septempunctata (L., 1758) (Coleoptera:Coccinellidae) in Vineyards
Authors: ASLAN Mahmut Murat , KOZANOĞLU Alper , UZUN A. Abdulkadir , DURMAZ H. Basri
Published: January 2019

The mating disruption method (MD), which is
biotechnical against Lobesia botrana
Den. et Schiff., a significant pest of vineyards, has been applied in
vineyards; and the area exposed to this application and the control trial area
(CA) were compared in terms of predators. Sampling was started on 07.04.2013
and 31.03.2014 in 2013 and 2014 at the mating disruption applied area and the
control trial area upon formation of the vine leaves. The result of the
sampling indicated that the most frequently seen predators were Chrysoperla carnea (Stephens, 1836)
(Neuroptera:Chrysopidae) and Coccinella
septempunctata (L., 1758) (Coleoptera:Coccinellidae). When the infestation
rate on the bunches in the vineyard, where mating disruption was applied,
exceeded 5%, that is the economic loss threshold, Bacillus thuringiensis ssp. kurstaki
was applied twice against the 1st and 3rd generations in 2013; and for 3 times
against the 1st, 2nd and 3rd generations in order to decrease the intensity of
the population. Insecticide was applied against L. botrana on the control trial area very frequently and
unconsciously; namely for 7 times until harvest in 2013, and for 8 times until
harvest in 2014. In the vineyard, where mating disruption was applied,
fungicides were applied for 5 times in 2013 against diseases such as Uncinula necator, Botrytis cinerea and Plasmopara viticola, however fungicides
were applied in the control trial area for 8 times in the same year; in 2014
fungicides were applied against the above-mentioned diseases on the mating
disruption applied area for 4 times, however fungicides were applied for 7
times on the control trial area in the same year.
Sustainability Management of Unesco Global Geoparks
Authors: Pásková Martina , Zelenka Josef
Published: January 2019

UNESCO global geoparkUNESCO global geoparks dynamic initiative draws attention of both experts and public by its innovatively holistic approach to conservation, presentation and interpretation of the Earth heritage interrelating the geodiversity of the region with its biodiversity and cultural diversity. The objective of this contribution is to analyse the processes behind the sustainability management of the UNESCO global geoparks.The process analysis of the certification and revalidation schemes of the UNESCO global geoparks reveals a combined application of the interrelated approaches of the sustainability management, in particular the environmental quality management, knowledge management, strategic management and participative management. The environmental quality management, stimulating UNESCO global geoparks to implement their mission, is ensured through the system of initial certification and regular revalidations. The performance of the UNESCO global geoparks is coordinated on the continental and global levels. This networking facilitates an effective implementation of the knowledge management, which consists in the systematic sharing of knowledge and experience among individual geopark representatives. The participative management is implemented not only through the participation of the individual geoparks representatives in the decision making processes of the Global Geoparks Network and continental networks, but mainly through the participation of local actors in the activities of given UNESCO global geopark. The application of the strategic management ensures the long term balanced contribution of UNESCO global geoparks to the sustainable development and cultural identity of the given region. The analysis has shown a specific way in which the selected concepts of the sustainability management are implemented in the evaluation and revalidation procedures, networking and other pillars of the UNESCO global geoparks development.
Richard Ashley & Renee Timmers (editors), The Routledge Companion to Music Cognition
Authors: Henriquez Maria , Hashemian Sarah
Published: January 2019

No abstract available.
Commentary on "Two studies of Autonomous Sensory Meridian Response (ASMR): The Relationship between ASMR and Music-Induced Frisson" by Alexsandra Kovacevich and David Huron
Authors: Ruth Nicolas
Published: January 2019

No abstract available.
Congenital Infantile Fibrosarcoma of the Tongue: Case Report and Review of the Literature
Authors: Lee Francis , Ha Jennifer , Vijayasekaran Shyan
Published: January 2019

Introduction: Congenital infantile fibrosarcoma is often misdiagnosed. It may be more common than noted in the literature. We present an unusual case of paediatric head and neck fibrosarcoma.

Methods: Restrospective case report and literature review.

Results: We report the surgical management of a fibrosarcoma of the tongue in an 8-month-old child where neo-adjuvant chemotherapy was unsuccessful.

Conclusion: Surgical resection is the mainstay of treatment, in the head and neck region where critical structures are close to the tumour, complete resection with wide margins can be difficult. The role of chemotherapy is yet to be defined.
Administration of Beta-Emitting Anti-CD37 Radioimmunoconjugate Lutetium (177Lu) Lilotomab Satetraxetan as Weekly Multiple Injections Increases Maximum Tolerated Activity in Nude Mice with Non- Hodgkin Lymphoma Xenografts
Authors: Heyerdahl Helen , Repetto-Llamazares Ada H.V. , Dahle Jostein
Published: January 2019

Lutetium (177Lu) lilotomab satetraxetan (177Lu-lilotomab) is a novel anti-CD37 radioimmunoconjugate (RIC) currently in Phase 2b clinical trial for treatment of non-Hodgkin lymphoma (NHL). The aim of the current study was to investigate tolerability and anti-tumor efficacy of multiple dosing of 177Lu-lilotomab in vivo. Nude mice with subcutaneous (s.c.) NHL (Ramos) xenografts were given 2, 3 or 4 weekly injections of 300 MBq/kg 177Lu-lilotomab or NaCl. Treatment tolerability was assessed by body weight, hematology and histopathological evaluation. A separate experiment in mice without xenografts was performed to collect long term toxicity data. Mice in this study were dosed more conservatively with the intention that all mice should survive until end of experiment and were administered 2 or 4 weekly injections of 200 MBq/kg 177Lu-lilotomab or NaCl. Total accumulated activity of 900 MBq/kg 177Lu-lilotomab given as three weekly injections was tolerated by nude mice with s.c. Ramos xenografts, which is 50 % higher than the maximum tolerated activity (MTA) of a single injection of 530-600 MBq/kg. In the long-term toxicity animals, the highest accumulated activity tested, 800 MBq/kg, was also well tolerated. Radioactivity-dependent transient reduction in white blood cell and platelet counts occurred in all treated groups, with nadir 1-3 weeks after last injection. This toxicity was radioactivity dependent and consistent with histopathological changes in hemolymphopoietic tissues. Significant tumor growth delay measured as time to reach 4 times intial tumor volume was observed in all groups given multiple injections of 300 MBq/kg 177Lu-lilotomab compared to NaCl control group (p<0.001). In conclusion, weekly injections of 177Lu-lilotomab increase the accumulated MTA from 530 to 900 MBq/kg in nude mice, allowing the total injected activity and hence the radiation dose to tumor to be increased without increasing the toxicity to normal tissues.