bluuebunny/crossref_metadata_2025 huggingface dataset:
Gymnasieelevers anteckningspraktiker
Authors: Ragnefors Peter
Published: October 2022

Studies have shown that lecture note-taking is very effective for students’ learning. Research on Swedish pupils, however, is scant. The aim of the present study was to explore note-taking practices in Swedish upper secondary school and examine whether the school supports students in their practice. A survey with both closed-ended and open-ended questions was administered to 120 pupils from two schools in Västra Götaland County. Most pupils reported taking notes during lectures and doing so for mainly two reasons: to learn the material and to study the notes for future exams. However, only 15 % of participants had received guidance on how to take notes during their school years. A metacognitive framework is applied in interpreting the results. Whether a note-taking practice can be considered metacognitive depends on the underlying motives for choosing that strategy. A well-chosen strategy seems dependent on contextual and individual circumstances. It is suggested that pupils be taught both the advantages and the disadvantages of different note-taking practices, so that they can evaluate different strategies for themselves.
”Var i kroppen känns språken liksom?” Fyra flerspråkiga lärares reflektioner över yngre elevers språkliga identitetskonstruktioner
Authors: Snoder Sara
Published: October 2022

Alltfler lärare och elever i Sveriges grundskolor talar fler språk än endast svenska och engelska. Trots det är flerspråkig användning i skolans tidiga år i svenska klassrum relativt outforskad. Syftet med föreliggande artikel är att med hjälp av så kallade språkporträtt (Busch, 2017, 2018) belysa flerspråkiga grundskollärares reflektioner över sina elevers flerspråkighet och språkliga identitetskonstruktioner. Artikeln baseras på ett forskningsprojekt med en lingvistiskt etnografisk ansats vid två grundskolor med hög andel flerspråkiga elever och lärare, och här specifikt i tre klasser i årskurs 2 och 4. Det empiriska materialet består av fältanteckningar från observation av de flerspråkiga lärarnas modellering av den forskarinitierade aktiviteten (språkporträtt) med uppföljande audioinspelade lärarreflektionssamtal. I lärarnas reflektionssamtal framkom att de hade god kännedom om sina elevers språkliga repertoarer. Det som förvånade lärarna var i huvudsak att en del flerspråkiga elever endast angivit ett språk i sitt språkporträtt, samt att en del elever med svenska som enda modersmål verkar vilja lägga till fler språk till sin repertoar. De flerspråkiga lärarnas reflektioner visar på en känslomässig förståelse utifrån sina erfarenheter i relation till den egna flerspråkigheten. Den här specifika användningen av språkporträtt kan ge ökad kunskap om (fler)språkiga identitetskonstruktioner, samtidigt som de kan visa på komplexitet avseende flerspråkighet.
På spaning efter fritidspedagogisk undervisning
Authors: Dahl Marianne
Published: October 2022

The study aims at showing how teaching within school-age educare can be made visible through a LEGO project. Using Bernstein’s socio-linguistic theory, a re-analysis and a case-study are carried out. With a focus on how teachers teach, field notes from a previously conducted study are processed again. Results show that teaching within school-age educare is based on a visible pedagogy of both strong classification and framing, in line with a formal image of instruction. At certain times, the teaching becomes invisible, primarily from the children’s perspective, partly because of admonitions to maintain the project and partly because of the children’s sense of control whether project events are real or pretend. The play-oriented features and child focus in the project can be seen as a strategy, demonstrating opportunities of school-age educare teaching to create behavior that explores different knowledge. One conclusion highlights the teachers’ sense of intonation, an art requiring teachers to lead and participate in order to provide the conditions for learning. This teaching can complement the school.
Att motverka sexuella trakasserier - en didaktisk fråga
Authors: Eek-Karlsson Liselotte , Olsson Ragnar , Gunnarsson Gunilla
Published: October 2022

The aim of the present study is to contribute with knowledge about pupils’ views upon teachers’ teaching regarding the work of counteracting sexual harassment. 28 girls and 22 boys in secondary and upper secondary school were interviewed. The theoretical framework is based on an educational perspective and directed towards teachers’ work against oppression. More specifically it deals with the relationships between teacher and pupil, teacher and the knowledge content as well as the teaching process. The concept ‘teaching’ is understood as ‘teaching acts’ that are carried out both in formal teaching situations within specific lessons as well as in informal teaching situations in between the lessons. According to the pupils, a trusting climate between teachers and pupils is an essential condition for counteracting sexual harassment successfully. The result also shows that the knowledge content usually is mediated, as in traditional school practice, from the teacher to the pupils in specific lessons. The pupils find these fact-based lessons both relevant and irrelevant. Some lessons are based on the pupils’ own experiences and on limiting gender norms in society and in school. These lessons have a dialogical approach, where the teachers and pupils learn together based on a good relationship.
Ketidakpastian dan Pengambilan Keputusan pada Perusahaan Kecil di Jakarta
Authors: Pradana Adhitya Sunu , Pamulatsih Ratri Sri , Sudarmadji Sudarmadji , Baskoro Bimmo Dwi
Published: October 2022

Efektuasi telah diakui sebagai logika pengambilan keputusan yang paling tepat selama masa ketidakpastian. Namun terus-menerus diabaikan dalam literatur yang ada bahwa ketidakpastian tidak pernah konstan. Untuk mengisi ini, kami belajar bagaimana penerapan efektuasi bervariasi ketika ketidakpastian berubah. Temuan kami menunjukkan bahwa ketika pengusaha kecil merasakan ketidakpastian meningkat dari tingkat rendah menengah, mereka akan mengurangi penerapan logika efektual untuk melindungi keuntungan mereka. Namun, ketika mereka ketidakpastian ketidakpastian meningkat dari tingkat menengah ke ekstrem, mereka akan meningkatkan adopsi logika untuk memastikan kehidupan hidup. Lebih menarik lagi, untuk perusahaan dengan orientasi kewirausahaan (EO) yang lebih tinggi, efek lengkung ketidakpastian pada logika efektual akan diredam. Kami menduga ini disebabkan oleh fakta bahwa perusahaan EO yang mengandalkan postur strategi kewirausahaan mereka untuk bersaing di industri, daripada membiarkan menentukan bagaimana mereka melanjutkan.
Ujı efektıvıtas ekstrak daun pacıng (Costus speciosus) terhadap penyembuhan luka sayat pada hewan uji kelinci (Oryctolagus cuniculus)
Authors: Irma Novrianti  , Nengsi Sidar , Wijayanti Sari
Published: October 2022

Luka adalah keadaan dimana terjadi kerusakan jaringan tubuh yang mengganggu proses seluler normal yang melibatkan jaringan ikat, otot, dan kulit syaraf.  Banyak tumbuhan herbal yang telah dilaporkan memiliki efektifitas dalam penangan luka, salah satunya adalah tumbuhan pacing (Costus speciosus) baik akar maupun daun. Penelitian ini bertujuan untuk mengetahui efektifitas dan konsentrasi dari daun pacing yang dapat menyembuhkan luka sayat pada hewan uji kelinci. Ekstrak daun pacing diperoleh dengan cara maserasi menggunakan pelarut etanol 96%. Hewan uji yang digunakan adalah Kelinci (Oryctolagus cuniculus). Setiap hewan uji dibuat 5 kelompok, yaitu konsentrasi ekstrak 5%, konsentarsi ekstrak 10%, konsentrasi ekstrak 20%, kontrol negatif (basis gel), dan kontrol positif (salep betadin®). Setiap punggung kelinci dibuat menjadi 3 daerah yang telah dicukur dan diberikan sayatan pada daerah tersebut sepanjang 1 cm dengan kedalaman 0,3 cm. Pengukuran panjang luka sayat dilakukan setiap hari selama 7 hari, hasil pengukuran akan digunakan untuk perhitungan persentase kesembuhan yang kemudian akan dianalisis menggunakan metode Kruskal Wallis dan dilanjutkan menggunakan uji Mann-Whitney. Berdasarkan hasil penelitian diketahui bahwa kelompok konsentrasi ekstrak 20% menunjukkan penyembuhan luka paling baik sebesar  91% dengan panjang luka 0,09 cm pada hari ke-7 dengan nilai p sebesar 0,016. Nilai ini menunjukan bahwa terdapat perbedaan yang signifikan terhadap persentase penyembuhan luka sayat pada setiap kelompok hewan uji. Senyawa kimia yang terkandung dalam ekstrak etanol  daun pacing adalah senyawa flavonoid, tanin dan saponin. Berdasarkan hasil tersebut dapat disimpulkan bahwa ekstrak daun pacing (Costus speciosus) memiliki efektifitas dalam penyembuhan luka sayat pada hewan uji.
Ujı aktıvıtas anthelmıntık ekstrak etanol rımpang pacıng (Costus speciosus (Koen.) Sm.) terhadap cacıng tanah (Lubricus rubellus)
Authors: Benazir evita rukaya  , Syuhada Syuhada , Dewi Puspita Sari
Published: October 2022

Prevalensi masyarakat yang mengalami kecacingan di Indonesia pada umumnya masih sangat tinggi, terutama pada masyarakat yang kurang mampu dengan sanitasi yang buruk. Pemberian anthelmintik herbal merupakan solusi alternatif yang aman mengingat banyaknya anthelmintik konvensional yang telah mengalami penurunan efektivitas akibat meningkatnya kasus resistensi khususnya di Indonesia. Pacing (Costus Speciosus) merupakan salah satu tanaman yang berkhasiat sebagai anthelmintik dengan senyawa bioaktif berupa flavonoid (proantosianidin dan antosianin), glutathione, β-karoten, α-tokoferol, asam askorbat, senyawa fenol, tricontanoic curcumin, gracillin, sitosterol-β-D-glukosida, tricontanoic dan dioscin. Pada penelitian ini, dilakukan pengujian anthelmintik untuk mengetahui aktivitas ekstrak etanol rimpang pacing dalam menghambat aktivitas cacing tanah (Lumbricus rubellus). Uji aktivitas antelmintik ekstrak etanol rimpang pacing dilakukan dengan menggunakan metode in-vitro. Pengujian diawali dengan membuat 5 kelompok perlakuan yang masing-masing diberi 3 ekor cacing tanah dengan 3 replikasi. Kelompok perlakuan 1,2 dan 3 diberikan ekstrak etanol rimpang pacing masing-masing sebesar 5%, 7,5% dan 15% sedangkan untuk kelompok 4 diberikan NaCMC 0,5% dan kelompok 5 diberikan Mebendazole 2%. Pengamatan aktivitas anthelmintik dilakukan dengan menghitung waktu yang dibutuhkan sampel uji untuk melumpuhkan (paralisis) dan mematikan (mortalitas) cacing tanah selama 3 jam perlakuan. Adapun hasil penelitian yang diperoleh yaitu waktu paralisis cacing tanah selama perlakuan pada kelompok 1,2,3,4 dan 5 adalah 27,2±3,7 menit, 11,7±0,3 menit, 14,6±0,02 menit, 98,3±2,5 menit dan 63,6±48,5 menit. Sedangkan waktu mortalitas cacing tanah selama perlakuan pada kelompok 1,2,3,4 dan 5 adalah 63,2±6,8 menit, 30,3±0,0 menit, 29,2±0,0 menit, 116,3±43,3 menit dan 105±10,7 menit. Berdasarkan hasil penelitian tersebut maka dapat disimpulkan bahwa ekstrak etanol rimpang pacing memiliki aktivitas antelmintik dengan potensi yang sangat kuat, dimana waktu yang dibutuhkan ekstrak untuk melumpuhkan dan mematikan cacing tanah lebih cepat dibandingkan dengan kontrol positif (mebendazole 2%).
Perbandingan potensi antibiotik tablet amoxicillin generik dari beberapa produsen yang beredar di kota Tarakan
Authors: Benazir evita rukaya  , Sari Wijayanti
Published: October 2022

Persepsi masyarakat tentang kemanjuran, keamanan dan kualitas dipengaruhi oleh beberapa faktor antara lain merek, kemasan, harga obat dan isu peredaran obat palsu atau kualitas obat dibawah standar. Persepsi negatif yang ada, bukan hanya terkait perbandingan kualitas obat generik dan paten, namun perbandingan kualitas obat generik yang diproduksi oleh produsen yang berbeda dan dengan kemasan yang berbeda juga terjadi. Berdasarkan hal tersebut, maka peneliti melakukan pembuktian sederhana terkait kesetaraan potensi obat generik, dengan membandingkan daya hambat tablet amoxicillin generik dari beberapa produsen. Tujuan penelitian ini adalah untuk membandingkan potensi penghambatan tablet amoksisilin generik yang beredar di Kota Tarakan terhadap pertumbuhan bakteri uji. Uji aktivitas antibakteri amoksisilin dari 3 pabrik yang berbeda dengan konsentrasi 16 g/100µl terhadap Staphylococcus aureus dan Escherichia coli dilakukan dengan metode sumuran. Amoksisilin (x), (y), dan (z) digunakan sebagai bahan uji dan aquadest steril sebagai kontrol negatif. Penentuan potensi dilakukan dengan mengukur diameter zona hambat yang terlihat pada media Mueller Hinton Agar (MHA) yang telah diberi intervensi. Hasil yang diperoleh akan dianalisis menggunakan software SPSS dengan uji Post Hoc-Tukey. Hasil penelitian ini menunjukkan bahwa Amoksisilin (x), (y), dan (z) memiliki potensi yang sama dengan signifikansi > 0,05 untuk kedua bakteri uji dengan ukuran zona hambat rata-rata 25 mm terhadap Staphylococcus aureus dan 34 mm terhadap Escherichia coli. Dari hasil penelitian tersebut dapat disimpulkan bahwa tablet amoksisilin generik yang beredar di Kota Tarakan memiliki potensi yang sama untuk kedua bakteri tersebut.
Hubungan dukungan keluarga dengan kualıtas hıdup anak thalasemıa
Authors: Katimenta Karmitasari Yanra , Agustina Nugrahini  , Wenna Araya  , Erista Rusana
Published: October 2022

Thalasemia merupakan penyakit kelainan darah bawaan yang menyebabkan anemia yang mengharuskan pasien mendapatkan tranfusi darah seumur hidupnya, hal ini berdampak pada penurunan kualitas hidup. Kualitas hidup anak thalasemia adalah persepsi anak thalasemia tentang hidupnya di dalam lingkungan dia hidup yang dihubungkan dengan tujuan, harapan dan perhatian yang dimiliki. Oleh karena itu dukungan keluarga diperlukan untuk meningkatkan kualitas hidup anak thalasemia. Penelitian ini bertujuan untuk mengetahui hubungan dukungan keluarga dengan kualitas hidup anak thalasemia di ruang Flamboyan RSUD dr. Doris Sylvanus Palangka Raya. Penelitian ini menggunakan desain penelitian korelasi dengan pendekatan cross sectional dengan jumlah sampel 30 orang menggunakan tehnik total sampling dan uji statistik Spearmen rank. Penelitian menunjukkan dukungan keluarga yang positif sebanyak 26 responden (87%) dan kualitas hidup normal sebanyak 24 responden (80%). Berdasarkan analisis dengan uji Spearmen rank diperoleh p value <0,05, artinya terdapat hubungan antara dukungan keluarga dengan kualitas hidup anak thalasemia. Hasil penelitian ini menunjukkan terdapat hubungan yang signifikan antara dukungan keluarga dengan kualitas hidup anak thalasemia. Anak dengan dukungan keluarga positif menunjukkan kualitas hidup yang lebih baik dibandingkan anak dengan dukungan keluarga negatif.
Potensi peningkatan efek sedasi dan gangguan ritme jantung pada pengobatan skizofrenia
Authors: Julaeha Julaeha , Nurhaliza
Published: October 2022

Skizofrenia paranoid merupakan tipe skizofrenia yang paling banyak diderita di berbagai negara.   Gejala psikosis yang dialami berupa delusi yang secara relatif stabil, seringkali bersifat paranoid, biasanya disertai dengan halusinasi, terutama halusinasi pendengaran, dan gangguan persepsi. Pasien “X” berumur 22 tahun dirawat dan didiagnosa skizofrenia paranoid dengan keluhan gelisa selama 4 hari terakhir, emosi labil, teriak-teriak, memukul, mengancam akan membunuh. Pasien mendapatkan terapi risperidon 2 mg, lorazepam 1 mg, trifluoferazin 5 m, dan olanzapin 5 mg. Masalah terkait obat yang ditemukan adalah adanya interaksi obat risperidon dengan lorazepam, yaitu dapat meningkatkan sedasi dan trifluoferazin dengan risperidon dapat memperpanjang interval QT. Pemantauan perbaikan gejala psikosis, efek sedasi dan gangguan ritme jantung perlu dilakukan utuk memastikan keberhasilan dan keamanan dari terapi yang diberikan.
Uji aktivitas fraksi n-hexan dan etil asetat ekstrak etanol daun pepaya (Carica papaya L.) terhadap Propionibacterium acnes
Authors: Fauziah Syarifah Nur , Rukaya Benazir Evita , Syuhada
Published: October 2022

Pepaya (Carica papaya L.) merupakan salah satu buah dengan banyak manfaat, termasuk dalam pemanfaatannya sebagai obat tradisional. Secara tradisional daun pepaya digunakan dalam pengobatan jerawat. Penelitian ini bertujuan untuk mengetahui aktivitas fraksi n-hexan dan etil asetat ekstrak etanol daun pepaya terhadap pertumbuhan Propionibacterium acnes. Fraksi n-hexan dan etil asetat diperoleh dengan melakukan ekstraksi bertingkat menggunakan metode maserasi. Fraksi yang diperoleh kemudian diuji menggunakan metode difusi agar (sumuran) untuk melihat efektivitasnya dalam menghambat pertumbuhan bakteri Propionibacterium acnes. Hasil uji yang diperoleh dari fraksi n-hexan dan etil asetat konsentrasi 10%, 15% dan 20% dengan kontrol positif erythromicin 0,375%, dan kontrol negatif pelarut (n-hexan dan etil asetat) berupa diameter zona hambat. Fraksi etil asetat dengan konsentrasi 10%, 15% dan 20% merupakan fraksi yang paling efektif dengan diameter rata-rata sebesar 14,7±6,33; 16,4±1,55; dan 18,7±4,14. Kesimpulan yang diperoleh dari penelitian ini adalah fraksi etil asetat daun pepaya konsentrasi 15% adalah fraksi yang paling optimal dalam menghambat pertumbuhan bakteri Propionibacterium acnes.
Uji stabilitas fisik serum anti-aging ekstrak etil asetat daun cempedak (Arthocarpus champeden Spreng.)
Authors: Salsabyla Asky  , Benazir Evita Rukaya  , Mustamin Faizal
Published: October 2022

Salah satu kosmetik popular yang dianggap efektif dalam mengatasi penuaan kulit adalah serum anti-aging dengan kandungan antioksidan kuat. Antioksidan alami sebagian besar diperoleh dari tanaman salah satunya berasal dari daun cempedak (Arthocarpus champeden Spreng.). Tujuan dari penelitian ini adalah melakukan evaluasi stabilitas fisik formula serum ekstrak etil asetat daun campedak (EEADC) menggunakan hasil penelitian sebelumnya. Formulasi serum dengan konsentrasi zat aktif sebesar 0,05% yang telah dibuat, dievaluasi stabilitas fisiknya selama masa penyimpanan hari ke-0, 2, 4 dan 7, yang meliputi uji organoleptik, homogenitas, pH, daya sebar, dan viskositas, kemudian dilakukan analisis data. Hasil dari evaluasi yang dilakukan menunjukkan bahwa serum EEADC memenuhi kriteria standar untuk evaluasi organoleptik, homogenitas dan pH. Namun, pada evaluasi daya sebar dan viskositas sebaliknya (tidak memenuhi kriteria standar). Sehingga dapat disimpulkan bahwa perlu dilakukan evaluasi dan optimasi formula serum EEADC.
Analısıs karakterıstık organoleptıs dan kimia tepung ıkan sepat rawa (Trıchopodus trıchopterus)
Authors: Endah Bella Rosalina , Yanti Fitri , Astuti Karunita Ika , Vebruati Vebruati
Published: October 2022

Ikan sepat rawa (Trıchopodus trıchopterus) merupakan hewan yang banyak ditemukan di Kalimantan Selatan. Ikan sepat rawa muncul musiman namun belum dimanfaatkan secara maksimal. Penelitian ini bertujuan untuk mengatahui karakteristik oraganoleptis dan kimia berupa kadar air, kadar abu, kadar serat, kadar lemak dan kadar protein tepung ikan sepat rawa. Pembuatan tepung ikan sepat rawa dengan menggunakan metode pengukusan pada suhu 90˚C selama 20 menit dan pemanasan oven dengan suhu 70˚C selama 80 menit. Hasil penelitian ikan sepat rawa menunjukkan karakteristik organoleptis berupa warna cokelat muda, aroma harum/khas, rasa hambar kemanisan, dan tekstur kering sedangkan hasil analisis kimia didapatkan kadar protein sebesar 44,84%, kadar serat 1,88%, kadar lemak 4,12%, kadar abu 14,63%, dan kadar air 5,98%. Berdasarkan Standar Nasional Indonesi (SNI), dari kelima pengujian karakteristik kimia didapatkan hasil uji kadar protein termasuk dalam standar mutu III, serat termasuk dalam standar mutu II, kadar lemak termasuk dalam standar mutu I, kadar abu termasuk standar mutu I, kadar air temasuk standar mutu  I.
Fraksinasi dan identifikasi senyawa tanin dari ekstrak pandan hutan (Freycinetia sessiliflora Rizki)
Authors: Ferdinan Ade , Rizki Fitri Sri , Kurnianto Erwan , Kurniawan Kurniawan
Published: October 2022

Tumbuhan pandan hutan yang terdapat di gunung Passi Singkawang dengan spesies Freycinetia sessiliflora Rizki belum banyak diteliti terutama kandungan senyawa kimianya. Tujuan dilakukannya penelitian ini adalah fraksinasi dan identifikasi senyawa tanin ekstrak etanol pandan hutan Freycinetia sessiliflora Rizki. Metode fraksinasi yang digunakan adalah kromatografi lapis tipis yang dilanjutkan dengan kromatografi kolom. Skrining fitokimia menggunakan pereaksi FeCl3 serta analisis menggunakan spektrofotometri UV-Vis. Hasil pemisahan dengan metode kromatografi lapis tipis dan kromatografi kolom menggunakan eluen kloroform: methanol: air (7:3:0,4) dengan nilai Rf 0,25-0,77. Analisis panjang gelombang menggunakan spektrofotometri UV-Vis menunjukan senyawa tanin dengan panjang gelombang maksimum 734,1 nm.
The Effect of Competence and Independence on Professional Skepticism and Audit Quality
Authors: Hadisantoso Erwin , Nurdin Emillia , Akib Mulyati
Published: October 2022

This study empirically examines the influence of competence and independence on professional skepticism and its relationship to audit quality (BPKP Representative Office of South Sulawesi Province). This research is descriptive quantitative research, which uses primary data. The sample of this research is the Auditor of the BPKP Representative Office of South Sulawesi Province, amounting to 46 people. The hypothesis test used is Structural Equation Modeling (SEM) analysis based on variance, namely Partial Least Square (PLS). The results of this study indicate that competence has a positive and significant effect on professional skepticism, independence has a positive and significant effect on professional skepticism, competence has a positive and significant impact on audit quality, independence has a positive and significant effect on audit quality and professional skepticism has a positive impact and essential to audit quality.
Otizm ve Oksidatif Stres: Bir Vaka Kontrol Çalışması
Authors: SUBAŞI TURGUT Fatma , KARADAĞ Mehmet , TAYSİ Seyithan , HANGÜL Zehra , GÖKÇEN Cem
Published: October 2022

Giriş ve Amaç: Otizm Spektrum Bozukluğunun etiyolojisini saptamaya yönelik çalışmalarda kesin bir sebep bulunamamış olmakla birlikte literatürde artan kanıtlar, oksidatif stresin otizmin gelişimi ve klinik tezahüründe rol oynadığını düşündürmektedir. Çalışmamız oksidatif stres ile otizm spektrum bozukluğu arasındaki ilişkinin değerlendirilmesinde güçlü bir oksidan olan peroksinitritin destekleyici biyokimyasal belirteç olarak kullanılıp kullanılamayacağını araştırmak için tasarlanmıştır ve bildiğimiz kadarıyla peroksinitritin otizmli çocukların serumlarında çalışıldığı ilk çalışmadır.
Yöntemler: Araştırmamızda 3-12 yaş aralığındaki 40 otizmli çocuk ile aynı yaş grubundaki 40 sağlıklı kontrol çocuğun serum peroksinitrit düzeyleri ölçülmüş ve peroksinitrit düzeyi ile otizm şiddeti arasındaki ilişki araştırılmıştır. Otizm semptomlarının şiddeti, Childhood Autism Rating Scale puanlarına göre değerlendirildi.
Bulgular: Çalışmamızda vaka ve kontrol grupları arasında peroksinitrit değerleri açısından istatistiksel olarak anlamlı farklılık belirlenmiştir (p=0,010). Verilerimiz Peroksinitrit düzeyleri ile otizm şiddeti arasında ise anlamlı ilişki olmadığını göstermektedir (p=0,527).
Sonuç: Bulgularımız otizmde oksidatif stresin arttığına dair artan kanıtlarla tutarlı olarak peroksinitrit düzeylerinin otizm tanısı olan grupta daha yüksek olduğunu göstermekte ve oksidatif stresin otizm patofizyolojisindeki rolüne işaret etmektedir. Peroksinitrit gibi güçlü oksidanlar ve bu yolaktaki farklı biyobelirteçlerin kombinasyonlarının dikkate alınarak tasarlandığı çalışmaların Otizm Spektrum Bozukluğu fizyopatolojisinin daha iyi anlaşılmasını sağlayabileceği ve potansiyel tedaviler için yol gösterici olabileceği düşünülmektedir.
Ureteral Obstruction Due to Inadvertent Placement of the Suprapubic Catheter and Bladder Indwelling Catheter: Presentation of Two Clinical Cases and Review of the Literature
Authors: Calderon Plazarte Victor , Taghavi Maxime , Jacobs Lucas , Noels Johanna Elisabeth
Published: October 2022

Introduction: Suprapubic catheter (SPC) and bladder indwelling catheter (BIC) placement are among the most common urological procedures. Inadvertent misplacement of the catheter tip into the ureteral orifice is an infrequent event with potentially critical complications. Case Presentation: We describe two cases of inadvertent intraureteral misplacement of an SPC and a BIC. A 66-year-old man with chronic kidney disease (CKD) stage G3b, urethral stenosis, long-term SPC who attended the emergency room (ER) 6 hours after the last catheter replacement due to low back pain, fever, deterioration of the general condition, anuria, acute kidney injury (AKI); CT-scan revealed a left uretero-hydronephrosis secondary to obstruction of the catheter balloon misplaced inside the distal ureter. A 59-year-old woman with CKD stage G3b, post-radiotherapy cystitis, and small capacity bladder, long-term BIC who attended the ER a few hours after the last BIC replacement due to abdominal pain, anuria, AKI; CT-scan revealed left hydronephrosis secondary to catheter obstruction within the distal ureter. In both patients, management was conservative, consisting of removing the catheter and repositioning it inside the bladder, in addition to hydration and antibiotherapy. Conclusions: These cases illustrate that awareness of this rare complication can be prevented by confirming the correct positioning of SPC or BIC after its replacement. Early detection and management of this complication can prevent a serious clinical setting.
Los asentamientos de Maṣmūda a ambos lados del Estrecho (siglos VIII-X). Estudio comparado de los paisajes actuales
Authors: García-Abad Alonso Juan Javier , De Felipe Helena
Published: October 2022

Este trabajo pretende ofrecer un modelo de análisis interdisciplinar sobre los asentamientos bereberes a ambos lados del Estrecho de Gibraltar. Para este estudio de caso histórico-geográfico se ha elegido el grupo bereber de los Maṣmūda y su trayectoria en al-Ándalus durante los siglos VIII-X. A partir de la documentación de las fuentes árabes, se ha seleccionado el espacio de la península tingitana para ser objeto de comparación desde el punto de vista del paisaje con enclaves ocupados por familias de este grupo en la península ibérica. Partiendo de estudios previos de catalogación de paisajes de España y Portugal, se ha efectuado una selección y cartografía y se ha confeccionado una tabla sistemática. Para el caso de Marruecos se han caracterizado y digitalizado ad hoc los entornos de los Maṣmūda de la península tingitana a partir de documentación geográfica diversa. Los resultados muestran que este grupo ocupó 31 asociaciones de paisajes en el conjunto ibérico-magrebí, en donde dominaron tierras bajas. La confección de una tabla sintética paisajística permite hacer una primera valoración de la diversificación alcanzada. Esta comparación pretende hacer una primera contribución a la reconstrucción del contexto geográfico y productivo del grupo Maṣmūda.
Ecología política de la frontera. Las membranas del metabolismo capitalista
Authors: Coronel Tarancón Alberto
Published: October 2022

Las fronteras juegan un rol central en la anatomía y fisiología política del Antropoceno. Antes que muros que separan territorios, son membranas que comunican metabolismos sociales. Desde el marco de la ecología política contemporánea, el artículo propone el análisis de las fronteras como órganos exosomáticos: membranas multifuncionales y permeables que participan de las funciones de circulación, inmunización y crecimiento de los metabolismos sociales capitalistas.
Adding Value to the Applied Sport Management Association
Authors: Martinez Mike
Published: October 2022

Dr. Martinez is the inaugural recipient of the Distinguished Service Award for the Applied Sport Management Association (ASMA). He offers his thoughts on adding value to ASMA to advance the association and sport management.
Suicide Intervention in Schools: If Not School Counselors, Then Who?
Authors: Gallo Laura , Wachter Morris Carrie A.
Published: October 2022

Youth suicide rates continue to rise each year. School counselors play an essential role in preventing suicide within K-12 schools. After the publication of the article, “Suicide Assessments: The Medical Profession Affirms School Counselors’ Truth,” in 2021 by Dr. Carolyn Stone, some confusion surfaced regarding professional school counselors’ responsibilities and liabilities around issues of suicide. To provide clarification, the role and training of school counselors are highlighted to provide evidence for their place in suicide risk assessment. Ethical implications and previous legal cases are provided to inform the profession. Training/supervision recommendations for counselor educators are also discussed.
Asymmetry in high-order harmonic generation of polar molecule CO
Authors: Yang Yan , Zhang Bin , Ren Zhong-Xue , Bai Guang-Ru , Liu Lu , Zhao Zeng-Xiu ,   Department of Physics, National University of Defense Technology, Changsha 410073, China,   School of Mathematics and Physics, North China Electric Power University, Beijing 100096, China
Published: October 2022

Compared with nonpolar molecules, owing to the inherent asymmetry, polar molecules exhibit rich and very complex electronic dynamics under the interaction with strong laser fields. In this work, high-order harmonic generation (HHG) of polar molecules CO is investigated by using the three-dimensional time-dependent Hartree-Fock (3D-TDHF) theory, with all electrons active. Through the high harmonic spectra and time-frequency analyses, it is found that when the laser field polarizes along the molecular axis, the ionized electrons from the two sides (C side and O side) contribute differently to the harmonic radiation. On the one hand, the harmonic intensity from the C side is greater than that from the O side, which is caused by the ionization rate. On the other hand, for the lower-order (7th–17th order) harmonics of plateau region, only the electrons from the C side participate in the HHG. However, for its higher part (18th–36th order), the electrons from both C side and O side contribute to high harmonics simultaneously. Moreover, the difference between contributions from two sides is related to the alignment angle θ between the laser polarization and the molecular axis, and it reaches a maximum value around θ = 0º and a minimum value around θ = 90º. There are two strong resonances around harmonic order H12.6 (19.5 eV) and H18 (27.9 eV) in the harmonic spectra when θ = 0º. The first resonance around H12.6 reveals that part of electrons ionized from the C side recombine to the vicinity of the further O nucleus. Near the second resonance around H18, there appears a shape resonance. Nevertheless, the shape resonances from the C and O sides are disparate. Based on the strong-field approximation theory, the ratio between photoionization cross sections from C and O sides around the shape resonance is calculated. The ratio is about 5.5 from 3D-TDHF, which is greater than the result of 3 simulated by ePloyScat, where only HOMO is considered. This discrepancy reveals that multi-electron effects enhance the asymmetry of polar molecules. This work provides an in-depth insight into the asymmetry in HHG of polar molecules, which benefits the generation of isolated attosecond pulse . It also promotes the application of high harmonic spectra in tracking the ultrafast dynamics of electrons.
Spatial modeling reveals nuclear phosphorylation and subcellular shuttling of YAP upon drug-induced liver injury
Authors: Wehling Lilija , Keegan Liam , Fernández-Palanca Paula , Hassan Reham , Ghallab Ahmed , Schmitt Jennifer , Tang Yingyue , Le Marois Maxime , Roessler Stephanie , Schirmacher Peter , Kummer Ursula , Hengstler Jan G , Sahle Sven , Breuhahn Kai
Published: October 2022

The Hippo signaling pathway controls cell proliferation and tissue regeneration via its transcriptional effectors yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ). The canonical pathway topology is characterized by sequential phosphorylation of kinases in the cytoplasm that defines the subcellular localization of YAP and TAZ. However, the molecular mechanisms controlling the nuclear/cytoplasmic shuttling dynamics of both factors under physiological and tissue-damaging conditions are poorly understood. By implementing experimental in vitro data, partial differential equation modeling, as well as automated image analysis, we demonstrate that nuclear phosphorylation contributes to differences between YAP and TAZ localization in the nucleus and cytoplasm. Treatment of hepatocyte-derived cells with hepatotoxic acetaminophen (APAP) induces a biphasic protein phosphorylation eventually leading to nuclear protein enrichment of YAP but not TAZ. APAP-dependent regulation of nuclear/cytoplasmic YAP shuttling is not an unspecific cellular response but relies on the sequential induction of reactive oxygen species (ROS), RAC-alpha serine/threonine-protein kinase (AKT, synonym: protein kinase B), as well as elevated nuclear interaction between YAP and AKT. Mouse experiments confirm this sequence of events illustrated by the expression of ROS-, AKT-, and YAP-specific gene signatures upon APAP administration. In summary, our data illustrate the importance of nuclear processes in the regulation of Hippo pathway activity. YAP and TAZ exhibit different shuttling dynamics, which explains distinct cellular responses of both factors under physiological and tissue-damaging conditions.
Proteomic analysis of IgM antigens from mammary tissue under pre- and post-cancer conditions using the MMTV-PyVT mouse model
Authors: Hernández Ávila Ricardo , Díaz-Zaragoza Mariana , Ostoa-Saloma Pedro
Published: October 2022

We analyzed the recognition of tumor antigens by IgM in transgenic MMTV-PyVT mice. PyVT female mice are a model of breast cancer that simulates its counterpart in humans. The PyVT model allows studying antigen recognition in two conditions: before and during tumor expression. We attempted to identify by sequence, the antigens recognized by IgM that are expressed or disappear in the membrane of breast transgenic tissue during the transition “No tumor-Tumor”. 2D immunoblots were obtained of isolated membranes from the breast tissue in the fifth, sixth, and seventh week (transition point). Proteins recognized by IgM were sequenced in duplicate by MALDI-TOF. In the transition, we observed the disappearance of antigens in transgenic mice with respect to non-transgenic ones. We believe that in the diagnosis of cancer in its early stages, the expression of early antigens is as important as their early delocalization, with the latter having the advantage that, under normal conditions, we can know which proteins should be present at a given time. Therefore, we could consider that also the absence of antigens could be considered as a biomarker of cancer in progress.
Artificial light at night correlates with seabird groundings: mapping city lights near a seabird breeding hotspot
Authors: Heswall Ariel-Micaiah , Miller Lynn , McNaughton Ellery J. , Brunton-Martin Amy L. , Cain Kristal E. , Friesen Megan R. , Gaskett Anne C.
Published: October 2022

Artificial light at night (ALAN) is a growing conservation concern for seabirds, which can become disoriented and grounded by lights from buildings, bridges and boats. Many fledgling seabirds, especially Procellariiformes such as petrels and shearwaters, are susceptible to light pollution. The Hauraki Gulf, a seabird hotspot located near Tāmaki Makaurau/Auckland, Aotearoa—New Zealand’s largest urban city, with a considerable amount of light pollution and regularly documented events of seabird groundings. We aim to identify the characteristics of locations especially prone to seabird groundings. We used an online database of seabirds taken to a wildlife rescue facility by the public to map 3 years of seabird groundings and test for correlations between seabird groundings and the natural night sky brightness. We found that areas with lower amounts of natural night sky brightness and greater light pollution often had a higher number of seabirds grounded. Further, we identified important seasonal patterns and species differences in groundings. Such differences may be a by-product of species ecology, visual ecology and breeding locations, all of which may influence attraction to lights. In general, seabird groundings correlate with the brightness of the area and are species-specific. Groundings may not be indicative of human or seabird population abundance considering some areas have a lower human population with high light levels and had high amounts of seabird groundings. These findings can be applied worldwide to mitigate groundings by searching and targeting specific brightly lit anthropogenic structures. Those targeted structures and areas can then be the focus of light mitigation efforts to reduce seabird groundings. Finally, this study illustrates how a combination of community science, and a concern for seabirds grounded from light attraction, in addition to detailed animal welfare data and natural night sky brightness data can be a powerful, collaborative tool to aid global conservation efforts for highly-at-risk animals such as seabirds.
Sleep Hygiene in Adolescents and Factors Influencing Sleep Pattern: A Cross-sectional Study from Southern India
Authors: Letchuman Selvakumar , Krishnamoorthy Vidhyasagar , Manga Hamsika Seetharaman , Sujatha Balamma , Kumar Santhosh
Published: October 2022

Introduction: Adolescence is an important period of growth and development. Sleep patterns undergo changes as the child transitions from adolescence to adulthood. A proper sleep hygiene for adolescents is important for their proper health, academic performance and prevention of adult-onset diseases. Aim: To assess sleep pattern and factors influencing sleep among adolescent school-going children. Materials and Methods: This cross-sectional questionnairebased study was conducted at Saveetha Medical College Hospital, Chennai, Tamil Nadu, India (tertiary care centre), from June 2021 to December 2021. School children aged 12-19 years, studying in class 8-12 were included in the study. Adolescent Sleep Hygiene Scale (ASHS) questionnaire, was used to collect information about the sleep practices. In addition, socio-economic class, start to school time, after school activities, sharing of bed room and access to personal devices like mobile phone were also noted. Sleep was assessed with regards to different parameters like physiological factors, cognitive and emotional factor, sleep environment factor, sleep stability factor, daytime sleep factor, bedtime routine factors. In addition, disturbance of sleep based on sharing of bed with others; use of social media, school routine preventing adequate sleep and presence or absence of outdoor activities was also assessed. The primary data was tabulated using Microsoft excel sheet. Analysis of the independent variables with dependant variables was done using a three-way Analysis of Variance (ANOVA) was done using Sigma Plot 13 (Systat Software, USA). Results: A total of 826 students were enrolled in the study. Majority of the study population was females (n=500). Mean age was 15.1±1.6 years. The mean sleep score was 118.7±14.3, out of a possible 150. Sleep stability and bedtime routine factors were the areas the children had lesser scores of 12.6 and 4.2 respectively, compared to other domains. Majority of the children (76.8%, 635) did not have a bedroom of their own and shared it with their parents, siblings or grandparents. Total 602 children did not have television inside their bedroom, likewise, access to computer was also limited (129,15.6%). Socio-economic status was found to be significantly impacting behavioural arousal factors (p-value=0.006), sleep environmental factors (p-value=0.009), sleep stability factors (p-value=0.001) and bedtime routine factors (p-value=0.004) as assessed using ASHS questionnaire. Conclusion: The overall sleep quality was good in the study population. In the Indian setting, the socio-economic class and the type of family play an important role in the sleep hygiene practices of an adolescent. School based and family-based interventions will do a lot of good to adolescent sleep hygiene thereby increasing their overall health, productivity and academic performance.
ОБРАЗОВАНИЕ И ПОДГОТОВКА РОССИЙСКИХ СПЕЦИАЛИСТОВ ПО ВОЗОБНОВЛЯЕМОЙ ЭНЕРГЕТИКЕ, "Энергия: экономика, техника, экология"
Authors: Бутузов В.А.
Published: October 2022

Представлены данные Международного экспертного сообщества по возобновляемой энергетике REN21 по электро- и теплогенерации на возобновляемых источниках энергии за 2020 г. В России в том же году мощность и выработка электрогенерации на возобновляемых источниках энергии составляла 4 ГВт и 4.2 ТВт · ч/год, а выработка тепловой энергии на возобновляемых источниках энергии превысила 30 ТВт · ч/год. В России 13 вузов и один научный центр РАН готовят специалистов с высшим образованием по специальности “Нетрадиционная и возобновляемая энергетика”. Только в 2021 г. выпущено более 300 специалистов. В семи вузах и одном учреждении РАН действуют аспирантуры по подготовке специалистов высшей квалификации по возобновляемой энергетики, в четырёх из которых работают диссертационные советы по этой специальности. Представлен обзор методической и научной деятельности кафедр и научно-образовательных центров 12 вузов и одного научного центра РАН “ВИМ”. Проанализирована обеспеченность литературой, лабораторным оборудованием, приведены результаты научной деятельности.
Key Factors, Drivers and Gatekeepers of Female Genital Mutilation in Ethiopia: A Meta-synthesis of National and Regional Studies
Authors: Oladeji Olusola , Battle Julia , Ahmed Haithar
Published: October 2022

Female Genital Mutilation (FGM) is a harmful practice that consists of all procedures involving partial or total removal of the female external genitalia or other injuries to the female genital organs for non-medical reasons. This meta-synthesis aimed to identify and describe key factors, drivers, and gatekeepers of FGM practices in Ethiopia and was conducted using systematic searches in electronic databases (PubMed, PsycINFO, and Google Scholar) and grey literature published from 2012 to 2021. The main factors and drivers of FGM practices were cultural and traditional practices including marriageability and religious obligations. Other drivers were poor enforcement of laws against the practice including medicalization of FGM practice. The key gatekeepers included traditional birth attendants who were also mostly female circumcisers; mothers, grandmothers, and older women who were reported as major promoters, circumcisers, and key decision makers on the practice. Religious leaders and health workers also played pivotal role in the prevention of FGM as trusted source of information dissemination. It is therefore important that Programme and policy strategies to eliminate the practice are tailored to the local context, not only addressing these factors and drivers but involving the gatekeepers.
Therapeutic Potential of Bioactive Compounds of Piper nigrum L. (Black Pepper): A Review
Authors: Halligudi Nirmala , Bhupathyraaj Mullaicharam , Hakak Marwa Hatem Sharif
Published: October 2022

The present study highlights the Bio activities and Pharmacology of Piper nigrum L. (Black Pepper). Piper nigrum L is commonly known as Kali Mirch, Pippali, Milagu Peppercorn, White pepper, Green pepper, Black pepper, and Madagascar pepper longum plant is a deciduous slender aromatic climber. The major source of bioactive constituents in black pepper is present in the fruits. It contains major pungent alkaloid piperine (1-peperoyl piperidine) which is known to possess pharmacological actions. Antimicrobial activity of black pepper evaluated the antibacterial potential of aqueous decoction of Piper nigrum L. (black pepper), against different bacterial isolates from oral cavity of individual volunteers.
Time to Resuscitate Cardiopulmonary Resuscitation: The 3R/CPR Refill-Recoil-Rebound
Authors: Nour Sayed
Published: October 2022

Introduction: Sudden cardiac arrest (SCA) remains a major healthcare issue worldwide with gloomy outcomes due to poor perfusion of cardiopulmonary resuscitation (CPR), deemed unsuitable for hemostatic conditions, cardiotorsal anatomy, electrophysiology, and thoracic biomechanics. Alternatively, we propose a new management, implementing rational exploitation of the stagnant blood masses: manually with a novel technique of cardiac massage and mechanically with a circulatory flow restoration (CFR) device.

Methods: Simulated chest compressions were performed through the 5th intercostal space in professional Lifeguards volunteers, placed in the left lateral decubitus position with raised legs and abdominal compression.

Results: Bypassing the sternal barrier, refilling the heart, and then compressing the chest with a recoil-rebound maneuver (3R / CPR) can significantly promote return of spontaneous circulation (ROSC). The effectiveness of the CFR device versus CPR has previously been demonstrated in the literature.

Conclusion: Unlike current CPR, the 3R/CPR adapts human morphology and provides adequate myocardial perfusion promoting ROSC safely, under all circumstances. Preclinical computational models can confirm the effectiveness of the technique.
Morphometric Analysis Using Geospatial Techniques: A Case Study from Halayapura Micro-Watershed of Tumkur District, Karnataka, India
Authors: Manoj N. , Rajashekarappa K. S. , Ashoka H. G. , Devaraja K. , Pasha Md. Majeed
Published: October 2022

Plans for land and water management in the Tumkur district of Karnataka's Halayapura micro-watershed were created using geospatial tools. The examination of morphological traits in a micro-watershed employed Arc GIS software. According to the current study, the drainage system had a dendritic design with trunk order 4. The micro-watershed has a maximum area of 503 ha, a maximum length of 4.40 km, and a maximum width of 2.20 km. The bifurcation ratio had a mean value of 2.5. It shows that there have been less structural disturbances to the micro-watershed. The region has permeable subsurface material, according to the drainage density value of 0.851 km. The micro-watershed is becoming closer to the watershed's elongated shape, according to the form factor value. The groundwater that can be used is 41.7 mm (70% of the expected recharge of 59.6 mm), and the recharge factor that was discovered was 7%. This indicates that 256.0 mm of water is total accessible resource, which includes soil moisture store, utilisable runoff, and recharge. Currently, 19.4% of the usable runoff is being used, and harvesting and conservation buildings are encouraging 9% of the extra water.
Nano Fertilizer: A Boon to Environment-friendly Agriculture
Authors: Vaishya Kushal , Pratap Dheer , Bhushan Ayush , Srivsatava Abhijeet , Siddqui Saba
Published: October 2022

For modern agriculture Food Production Systems (FPS) to feed the expanding population, improving Nutrient Usage Efficiency (NUE) with little environmental risk has become essential. A novel approach to the problem of poor or falling Nutrient Use Efficiency (NUE) with a little environmental impact has emerged: nanotechnology with nanoscale inputs for the development of Nano Agri-Inputs (NAIPs). The study of nanotechnology holds great promise for providing modern intensive agriculture with long-lasting solutions to its pressing problems. Nanotechnology uses small-sized materials called nano particles (1–100 nm), which offer special properties and advantages. Large surface area to volume ratio provides chance for better and more efficient interaction of nano particles to target areas in addition to many other advantages. In addition to providing crop production systems with sustainability, nano-fertilizers have the potential to meet plant nutritional needs without reducing crop yield. These nano-fertilizers take advantage of the dynamics of surface area, size, shape, and bio-assimilation. Their effectiveness was assessed based on studies conducted in several places with multiple crops over various crop seasons, both by research institutes and on the fields of progressive farmers spread out over 11,000 locations and 94 different crops in India. Separate tests for bio-efficacy, biosafety, toxicity, and environmental compatibility have been conducted on nano-nitrogen, nano-zinc, and nano-copper.