bluuebunny/crossref_metadata_2025 huggingface dataset:
Estudo da literatura sobre ciência aberta na ciência da informação
Authors: Menêses Raíssa da Veiga de , Moreno Fernanda Passini
Published: February 2020

O estudo tem como objetivo identificar as tendências e lacunas na literatura sobre Ciência Aberta na Ciência da Informação. Para isso, foram investigados os movimentos pertencentes à ciência aberta: acesso aberto, dados aberto, código aberto, ciência cidadã, recursos educacionais abertos, cadernos de laboratório abertos e revisão por pares aberta. A pesquisa é caracterizada como descritiva com natureza qualitativa, e o levantamento e análise de dados serão realizados de acordo com as estratégias da Revisão Sistematizada de Literatura. Na análise dos dados, os artigos selecionados serão classificados de acordo com as cinco escolas de pensamento propostas por Fecher e Friesike (2013). São elas: Pública, Democrática, Pragmática, Infraestrutura e Medição.
As primeiras normas epistolares da Companhia de Jesus
Authors: Silva Leonardo Gonçalves , Oliveira Lúcia Maciel Barbosa de
Published: February 2020

A Companhia de Jesus, em seus primórdios, tinha nas cartas o principal meio para a troca de informação entre seus religiosos espalhados pelas mais diversas partes do mundo. Contudo, tais cartas não eram escritas de acordo com o estilo ou a vontade do religioso que a escrevia; pelo contrário, obedeciam a rígidas normativas que regulavam tanto o conteúdo como a forma dessas cartas. Esta pesquisa teve como objetivo identificar e analisar quais foram as primeiras normas para a escrita epistolar da Companhia de Jesus. Para isso utilizou-se de revisão de literatura e da análise documental em três normas epistolares dos primeiros anos da Companhia: as Reglas (1547), alguns artigos das Constituições relativos ao tema (1558) e a Formula scribendi (1565), cuja tradução em língua portuguesa foi feita exclusivamente para esta pesquisa. A análise delas mostrou que a Companhia elaborou normativas rígidas para a produção e circulação das cartas: por determinarem questões como autores, destinatários, assuntos e os prazos das cartas, as normas epistolares foram de essencial importância para a criação e manutenção de uma rede de informações epistolares.Palavras-chave: Companhia de Jesus, Epistolografia, Manuais epistolares.
Desmistificando os princípios FAIR: conceitos, métricas, tecnologias e aplicações inseridas no ecossistema dos dados FAIR
Authors: Henning Patricia Corrêa , Ribeiro Claudio Jose Silva , Sales Luana Farias , Moreira Luiz Rebelo , Santos Luiz Olavo Bonino da Silva
Published: February 2020

Os princípios FAIR, um acrônimo para Findable, Accessible, Interoperable e Reusable, estão presentes nas discussões e práticas contemporâneas da ciência de dados, desde o início de 2014, e tiveram sua aplicação consolidada em 2017, quando a Comissão Europeia passou a exigir a adoção de plano de gestão de dados, com base nesses princípios, por projetos financiados por seus recursos. Desde então, tais princípios passaram a ser norteadores da descoberta, do acesso, da interoperabilidade, do compartilhamento e da reutilização dos dados de pesquisa. No entanto, quando colocados em prática levantam dúvidas e imprecisões, gerando diferentes interpretações, o que dificulta sua aplicação. Por essa razão buscou-se elucidar seu entendimento, utilizando-se de conceitos esclarecedores, apresentando métricas específicas que medem o nível de FAIRnessdos objetos digitais; disseminando a proposta do ecossistema dos dados FAIR e as tecnologias Data FAIRPort e FAIR Data Point. Apresentamos, ainda, estudos realizados na Europa que comprovam o impacto e o potencial desses princípios, em diferentes áreas disciplinares, dando destaque às necessidades e aos exemplos de aplicação. A abordagem metodológica desta pesquisa é de natureza bibliográfica e de caráter qualitativo dando ênfase na descrição conceitual dos elementos necessários para a compreensão do ecossistema FAIR, o que permitiu, neste estudo, trabalhar a fundamentação teórica e conceitual, bem como o uso das práticas do FAIR em diferentes contextos e dimensões. As considerações finais corroboram as mudanças culturais e tecnológicas que vêm ocorrendo, no mundo informacional, relacionadas às novas práticas de gestão de dados e às interações e parcerias necessárias para a sua complexaimplementação.
Cadastro Nacional de Entidades Custodiadoras de Acervos Arquivísticos: diversidade custodial e políticas de memória
Authors: Venancio Renato Pinto
Published: February 2020

A boa gestão de arquivos dependeque eles sejam conhecidos eidentificados. Por isso o Conselho Nacional de Arquivos-Conarq aprovou uma Resolução, em 2019, visando identificar as instituições custodiadoras de acervos arquivísticos e lhe atribuir um código. O presente texto, através da análise documental e da seriação de dados, identifica o perfil institucional dessas instituições custodiadoras.Por meio desses procedimentos procura-se conhecer a realidade custodial brasileira e a importância da implementação de políticas de memória que levem em conta essa diversidade. Essa perspectiva também se desdobra em outra bem mais ampla, que diz respeito àpossibilidade de se pensar o fenômeno pós-custodial, em paralelo ao custodial, e suas implicações na preservação dos documentos eletrônicos como registros da memória.
O Brasil no contexto da sociedade da informação, à luz do regime global emergente de informação
Authors: Rêgo Herbert Oliveira , Freire Isa Maria
Published: February 2020

Este resumo de projeto de tese compartilha algumas reflexões do projeto de tese “O Brasil no contexto da sociedade da informação, à luz do regime global emergente de informação”, resultado de questionamentos e observações ao longo de pesquisas e publicações dos autores e de suas participações no Laboratório de Tecnologias Intelectuais – LTi. O objetivo é o de analisar as Políticas Brasileiras de Informação, de modo a identificar subsídios que comprovem, ou não, a inserção do Brasil no regime global emergente de informação. Discorre sobre as políticas de informação que foram relevantes para que diversos países, ou regiões, pudessem alavancar o nível de bem-estar de suas populações através de sua inserção na sociedade da informação. Observa que, no Brasil, houve uma descontinuidade na rota traçada em direção à Sociedade da Informação. O espectro teórico está inserido nas políticas de informação, mais precisamente na análise da problemática a partir do conceito do regime global emergente de informação, com sua concepção macro-política. Discute a atual situação do Brasil frente à sociedade da informação, esperando um melhor entendimento crítico e científico sobre as decisões tomadas em um passado próximo.
Palavras-chave: Regime global emergente de informação. Políticas de informação. Sociedade da Informação. Brasil.
Descarga sólida em suspensão em uma bacia hidrográfica com a predominância de pastagem
Authors: Bento Nicole Lopes , Amorim Jhones da Silva , Barros Flávia Mariani , Da Silva Danilo Paulucio
Published: February 2020

A erosão do solo acarreta na perda de aproximadamente dez hectares de terras produtivas a cada ano no mundo, acarretando em problemas ambientais e socioeconômicos. Diante disso, este estudo objetivou avaliar a descarga de sedimentos (Qs) na bacia hidrográfica do rio Catolé Grande, Bahia, relacionando-a com a descarga líquida (Q) e turbidez. Foram realizadas 34 coletas durante o ano de 2015 em uma seção de controle situada no município de Itapetinga. As análises das variáveis seguiram o que preconiza a APHA e a relação entre elas foi avaliada utilizando os coeficientes de determinação (R²) e raiz quadrada do erro médio (RMSE). A perda máxima de solo encontrada foi de 84,13 Ton.dia-1 no mês de julho e o modelo que melhor explicou Qs em função da Q no período de estudo foi o potencial, com valores de R² e RMSE de 0,911 e 4,824, respectivamente. Observou-se também o aumento da Qs em função do acréscimo da precipitação total nos sete dias antecedentes às coletas, o que pode estar relacionado ao uso predominantemente de pastagem na bacia. Não foi observado uma correlação significativa entre a turbidez e a Qs na faixa de vazão deste estudo.
AVALIAÇÃO DE DIFERENTES CENÁRIOS NA PRODUÇÃO DE SEDIMENTOS EM UMA MICROBACIA HIDROGRÁFICA AMAZÔNICA
Authors: Almeida Frederico Terra de , Dorneles Jonatan Iago , Zolin Cornélio Alberto , Souza Adilson Pacheco de , Schneider Roselene Maria
Published: February 2020

O objetivo deste trabalho foi estimar a produção de sedimentos na microbacia hidrográfica do rio Caiabi (MBHRC) utilizando a MUSLE com um evento de precipitação comum à região, avaliando seus parâmetros e a importância do seu uso aliado ao SIG para a observação de diferentes cenários. Na simulação foram gerados os mapas do fator R, fator K, fator topográfico LS e o fator C. Foram utilizadas imagens de satélites dos anos de 1993 e de 2015 para representar o uso e ocupação do solo. O cenário com uso do solo similar ao proposto no código florestal brasileiro e condição de superfície favorável (C1) e em condição de superfície desfavorável (C2) produziram 282,37 Megagramas (Mg) e 1.309,93 Mg respectivamente. No cenário com uso do solo mais próximo ao atual e condição de superfície favorável (C3) e condição de superfície desfavorável (C4) tiveram respectivamente 1.194,55 Mg e 3.167,56 Mg. O C1 foi o que apresentou a menor produção de sedimentos e o menor potencial erosivo. Já a análise conjunta dos cenários C2 e C3 demonstrou que a conversão de área de floresta para uso alternativo não aumentou a produção de sedimentos.
A arte da boa morte
Authors: De Sousa Cavalcante João Victor
Published: February 2020

O trabalho elabora questionamentos sobre os processos de tradução intersemiótica e adaptação fílmica presentes no longa-metragem Adaptation (2002). Interessa-nos discutir como a problemática da tradução reverbera na escrita da narrativa fílmica, buscando pensar os processos tradutores, nos quais situamos a adaptação, como poética sincrônica, que borra as fronteiras entre regimes estéticos distintos, notadamente entre sistemas de signos verbais e visuais. O filme, dirigido por Spike Jonze e roteirizado por Charlie Kaufman, é uma adaptação do livro-reportagem O Ladrão de Orquídeas (The Book Thief, 1998) da jornalista norte-americana Susan Orlean. O longa acompanha o personagem Charlie Kaufman (homônimo ao roteirista) na tarefa de adaptar o livro para o cinema, trabalho que leva o protagonista a defrontar-se com o problema da intraduzibilidade, evocada no filme pela noção de luto e pela aparição da figura do duplo.
ROBERTO ALENCAR DO DESENHO À CENA E VICE-VERSA
Authors: Dias Wagner Miranda
Published: February 2020

O artigo investiga os percursos de criação do artista do corpo Roberto Alencar, refletindo sobre a produção do grotesco em seu trajeto criativo, destacando as relações entre desenho e corpo. A análise foi elaborada por meio do estudo de documentos de processos criativos de Alencar, criados no desenvolvimento de seu trabalho, à luz das teorias de Cecília Almeida Salles sobre crítica de processos de criação, que tem como base a semiótica de C.S. Peirce e propõe diálogos com autores como Victor Hugo, Vsevolod Meyerhold e Mikhail Bakhtin.
c-Credibility measure
Authors: Ralevic Nebojsa , Paunovic Marija
Published: February 2020

In this paper we introduce the concept of credibility measure and we show
some of its basic properties. In this frame we present several results for
credibility mappings. Our results generalize the notion of the credibility
measure of Lee.
On difference of operators with different basis functions
Authors: Gupta Vijay , Acu Ana
Published: February 2020

In the recent years several researchers have studied problems concerning the
difference of two linear positive operators, but all the available literature
on this topic is for operators having same basis functions. In the present
paper, we deal with the general quantitative estimate for the difference of
operators having different basis functions. In the end we provide some
examples. The estimates for the differences of two operators can be obtained
also using classical result of Shisha and Mond. Using numerical examples we
will show that for particular cases our result improves the classical one.
Some interesting results on F-metric spaces
Authors: Beraz Ashis , Garai Hiranmoy , Damjanovic Bosko , Chanda Ankush
Published: February 2020

In this manuscript, we prove that the newly introduced F-metric spaces are
Hausdorff and first countable. We investigate some interrelations among the
Lindel?fness, separability and second countability axiom in the setting of
F-metric spaces. Moreover, we acquire some interesting fixed point results
concerning altering distance functions for contractive type mappings and
Kannan type contractive mappings in this exciting context. In addition, most
of the findings are well-furnished by several non-trivial examples. Finally,
we raise an open problem regarding the structure of an open set in this
setting.
Twoweak solutions for a singular (p,q)-Laplacian problem
Authors: Behboudi F. , Razani A.
Published: February 2020

Here, a singular boundary value problem involving the (p,q)-Laplacian
operator in a smooth bounded domain in RN is considered. Using the
variational method and critical point theory, the existence of two weak
solutions is proved.
Generalized truncated distributions with N intervals deleted: Mathematical definition
Authors: El-Hadidy Mohamed
Published: February 2020

The distributions obtained by N intervals truncations are characterized by
its high sensitivity for stochastic volatility data. In stable intervals, we
use this method to delete some certain range of data values from a domain of
the random variable. A comprehensive treatment of the statistical properties
of this distribution is presented. We assume Normal and Log-Lindley
distributions to apply the obtained results.
New modified Baskakov operators based on the inverse Pólya-Eggenberger distribution
Authors: Deo Naokant , Dhamija Minakshi , Miclăuş Dan
Published: February 2020

In the present article we introduce some modifications of the Baskakov
operators in sense of the Lupa? operators based on the inverse
P?lya-Eggenberger distribution. For these new modifications we derive some
direct results concerning the uniform convergence and the asymptotic
formula, as well as some quantitative type theorems.
Infinitely many solutions for mixed Dirichlet-Neumann problems driven by the (p,q)-laplace operator
Authors: Vetro Francesca
Published: February 2020

We study a nonlinear problem with mixed Dirichlet-Neumann boundary conditions
involving the p-Laplace operator and the q-Laplace operator ((p,q)-Laplace
operator). Using variational tools and appropriate hypotheses on the
behavior either at infinity or at zero of the reaction term, we prove that
such a problem has infinitely many solutions.
Pemanfaatan Manggis Sebagai Sediaan Antiseptik dalam Upaya Peningkatan Kesehatan Masyarakat di Desa Sayang, Jatinangor, Sumedang
Authors: Wathoni Nasrul , Putri Norisca Aliza , Cahyanto Arief , Muchtaridi Muchtaridi
Published: February 2020

Kuliah Kerja Nyata Mahasiswa (KKNM) merupakan suatu bentuk pengabdian mahasiswa kepada masyarakat, yang mana mahasiswa mengaplikasikan apa yang sudah diterima selama perkuliahan. KKN periode Juni 2019 bersifat terpadu dengan kegiatan Riset dan Pengabdian Pada Masyarakat (PPM) Dosen. Topik KKN-PPM yang didapat adalah ‘Pemanfaatan Manggis sebagai Sediaan Antiseptik dalam Upaya Peningkatan Kesehatan Masyarakat’. Program kerja ini dilaksanakan di Desa Sayang, Kecamatan Jatinangor, Kabupaten Sumedang. Manggis memiliki banyak manfaat bagi kesehatan, salah satunya kandungan Xanthone pada kulit manggis yang berfungsi sebagai antiseptik yang menjadi fokus program kerja KKN-PPM ini. Kulit manggis diolah menjadi produk antiseptik yang dapat digunakan secara praktis oleh masyarakat. Produk olahan dari kulit manggis berupa Sabun Cair Antiseptik dan Gel Antiseptik. Setelah kegiatan KKN-PPM ini berakhir, pengetahuan masyarakat tentang pengolahan buah atau tumbuhan sebagai produk yang bermanfaat bagi kebersihan dan kesehatan, khususnya buah manggis, diharapkan dapat bertambah.setelah dilakukannya penyuluhan mengenai betapa pentingnya menjaga kesehatan terutama pada hal mencuci tangan dengan benar maka dengan begitu tingkat kesehatan masyarakat akan meningkat seiring dengan peningkatan kesejahteraan ekonomi masyarakat. Dari kegiatan KKN Desa Sayang 2019 yang telah dilaksanakan ini, diharapkan masyarakat di Desa Sayang mampu memanfaatkan hasil perkebunan untuk diubah menjadi suatu produk yang mempunyai nilai lebih seperti gel antiseptik yang berbahan dasar kulit manggis yang banyak mengandung komponen bahan aktif Xanthone. Kulit manggis yang mengandung Xanthone tersebut dapat diolah menjadi sediaan antiseptik seperti sabun cair antiseptik dan gel antiseptik. Setalah dilakukan penyuluhan tentang manfaat buah manggis  kami mendapati bahwa pengetahuan masyarakat tentang manggis meningkat, khususnya pada pengetahuan tentang manfaat buah manggis yang saat pre-test sebanyak 76.92% menjawab benar kemudian saat post-test meningkat menjadi  84.61%.  Berdasarkan pre-test dan post-test yang kami lakukan juga dapat disimpulkan pengetahuan masyarakat tentang  buah manggis dapat diolah menjadi produk antiseptic juga meningkat, dimana saat pre-test 76.92% menjawab benar dan setelah post-test   100%  menjawab benar. Kemudian setelah dilakukan praktek langsung membuat gel antiseptic bersama masyarakat, berdasarkan post-test kami mendapati bahwa  46.15% masyarakat sangat tertarik dan 23.03% tertarik dengan gel antiseptic.Kata kunci: Manggis, Desa Sayang, Sabun Cair Antiseptik, Gel Antiseptik
Seed morphology and anatomy of Hypericum majus (A. Gray) Britton
Authors: Szkudlarz Piotr , Celka Zbigniew , Rosadziński Stanisław , Wojciechowicz Maria Katarzyna
Published: February 2020

Hypericum majus (A. Gray) Britton is an alien species for Europe. It originates from North America and, in recent years, has been spreading in Europe. Presently, this species is found in Germany, France, Italy, Bosnia and Herzegovina, and Belarus. In Poland, it was noted for the first time in 2017 in western part of the country. Thus far, no detailed morphology and anatomy of H. majus seeds based on light and electron microscopy studies has been presented. Considering the fact that seeds provide important taxonomical information and the discussed species has not been investigated in this respect, in this research, an attempt was made to broaden the present knowledge.

Investigations were conducted based on samples originating from three localities in Central Europe (Poland). The obtained results showed that H. majus seeds are very small – about 0.5 mm in length. In the SEM image, their surface is reticulate, typical of majority of species in this genus. Anatomical analysis showed that seed coat of matured seeds is very delicate, composed of two cell layers with strongly lignified walls.
Beneficial Effect of Pachyrhizus erosus Fiber as a Supplemental Diet to Counteract High Sugar-Induced Fatty Liver Disease in Mice
Authors: Santoso Putra , Maliza Rita , Fadhilah Qonitah , Insani Siti Jamalul
Published: February 2020

Background and aims: Edible fiber isolated from the tuber of yam bean (Pachyrhizus erosus, Leguminosae) has been suggested to prevent the development of metabolic diseases caused by excessively consuming sugary foods. However, it is unclarified whether P. erosus fiber (PEF) is also capable of preventing liver diseases. This study aimed to determine the effectivity of PEF in counteracting the development of non-alcoholic fatty liver disease (NAFLD) caused by excessive intake of high-sugar diet (HSD).

Material and method: 25% of PEF in HSD (w/w) was fed in BALB/c mice for eight weeks followed by subsequent morphological and histological examinations of the liver at the end of treatment in comparing with HSD alone.

Results: We found that supplementation of 25% PEF sustained the normal morphological feature of the liver in HSD-fed mice. Moreover, PEF also prevented the development of microvesicles in the liver tissue, nuclear shrinkage, and hepatolysis as indicators of liver disease. Macrophages infiltration as a marker of liver inflammation was also less observed in PEF-treated mice.

Conclusions: PEF could effectively elicit a beneficial effect against NAFLD caused by HSD. Hence, PEF is suggested to be used as a potent supplemental diet to preclude the metabolic diseases caused by HSD.
The Usage of Lasso, Ridge, and Linear Regression to Explore the Most Influential Metabolic Variables that Affect Fasting Blood Sugar in Type 2 Diabetes Patients
Authors: Farbahari Arash , Dehesh Tania , Gozashti Mohammad Hossien
Published: February 2020

Background and aims:To explore the most influential variables of fasting blood sugar (FBS) with three regression methods, to identify the existence chance of type 2 diabetes based on influential variables with logistic regression (LR), and to compare the three regression methods according to Mean Squared Error (MSE) value.

Material and Methods:In this cross-sectional study, 270 patients suffering from type 2 diabetes for at least 6 months and 380 healthy people were participated. The Linear regression, Ridge regression, and Least Absolute Shrinkage and Selection Operator (Lasso) regression were used to find influential variables for FBS.

Results:Among 15 variables (8 metabolic, 7 characteristic), Lasso regression selected HbA1c, Urea, age, BMI, heredity, and gender, Ridge regression selected HbA1c, heredity, gender, smoking status, and drug use, and Linear regression selected HbA1c as the most effective predictors for FBS.

Conclusion:HbA1c is the most influential predictor of FBS among 15 variables according to the result of three regression methods. Controlling the variation of HbA1c leads to a more stable FBS. Beside FBS that should be checked before breakfast, maybe HbA1c could be helpful in diagnosis of Type 2 diabetes.
Intellectual Field, Networks, and Reputation Economy in Romania After 1989
Authors: Lazăr Marius
Published: February 2020

In this article, I analyse the transformations of the Romanian post-communist intellectual elites, using as a case study the disputes in the cultural press in Romania from 2002 to 2004, disagreements that influenced the repositioning of the Romanian public intellectuals through ideological alignments. Those debates gave birth afterwards to a cohesive Conservative pole and to anti-conservative tendencies of diverse political orientations, which constitutes the origin of the current divisions of the intellectual space. The analysis combines the Bourdieusian perspective on the social field and the theory of social networks with the purpose to formulate a hypothesis concerning the competitions meant to produce and preserve the prestige of the status groups in the social space that generate conflicting ideological positions. It outlines an alternative form of reassessing the “reputation economy” outside the space of the commodity exchange economy, starting instead with symbolic exchanges. The study describes the social rationale behind status production, as a source of strategies for maintaining dominant positions in a social field.
Potential COVID-2019 3C-like Protease Inhibitors Designed Using Generative Deep Learning Approaches
Authors: Zhavoronkov Alex , Aladinskiy Vladimir , Zhebrak Alexander , Zagribelnyy Bogdan , Terentiev Victor , Bezrukov Dmitry S. , Polykovskiy Daniil , Shayakhmetov Rim , Filimonov Andrey , Orekhov Philipp , Yan Yilin , Popova Olga , Vanhaelen Quentin , Aliper Alex , Ivanenkov Yan
Published: February 2020

The emergence of the 2019 novel coronavirus (COVID-19), for which there is no vaccine or any known effective treatment created a sense of urgency for novel drug discovery approaches. One of the most important COVID-19 protein targets is the 3C-like protease for which the crystal structure is known. Most of the immediate efforts are focused on drug repurposing of known clinically-approved drugs and virtual screening for the molecules available from chemical libraries that may not work well. For example, the IC50 of lopinavir, an HIV protease inhibitor, against the 3C-like protease is approximately 50 micromolar, which is far from ideal. In an attempt to address this challenge, on January 28th, 2020 Insilico Medicine decided to utilize a part of its generative chemistry pipeline to design novel drug-like inhibitors of COVID-19 and started generation on January 30th. It utilized three of its previously validated generative chemistry approaches: crystal-derived pocked-based generator, homology modelling-based generation, and ligand-based generation. Novel druglike compounds generated using these approaches were published at www.insilico.com/ncov-sprint/. Several molecules will be synthesized and tested using the internal resources; however, the team is seeking collaborations to synthesize, test, and, if needed, optimize the published molecules.
Probing Competing Relaxation Pathways in Malonaldehyde with Transient X-Ray Absorption Spectroscopy
Authors: List Nanna Holmgaard , L. Dempwolff Adrian , Dreuw Andreas , Norman Patrick , Martínez Todd J.
Published: February 2020

Excited-state intramolecular hydrogen transfer (ESIHT) is a fundamental reaction relevant to chemistry and biology. Malonaldehyde is the simplest example of ESIHT, yet only little is known experimentally about its excited-state dynamics. Several competing relaxation pathways have been proposed, including internal conversion mediated by ESIHT and C=C torsional motion as well as intersystem crossing. We perform an in silico transient X-ray absorption spectroscopy (TRXAS) experiment at the oxygen K-edge to investigate its potential to monitor the proposed ultrafast decay pathways in malonaldehyde upon photoexcitation to its bright S2(pp*) state. We employ both restricted active space perturbation theory and algebraic diagrammatic construction for the polarization propagator along interpolated reaction coordinates as well as representative trajectories from ab initio multiple spawning simulations to compute the TRXAS signals from the lowest valence states. Our study suggests that oxygen K-edge TRXAS can distinctly fingerprint the passage through the H-transfer intersection and the concomitant population transfer to the S1(np*) state. Potential intersystem crossing to T1(pp*) is detectable from reappearance of the double pre-edge signature and reversed intensities. Moreover, the torsional deactivation pathway induces transient charge redistribution from the enol side towards the central C-atom and manifests itself as substantial shifts of the pre-edge features. Given the continuous advances in X-ray light sources, our study proposes an experimental route to disentangle ultrafast excited-state decay channels in this prototypical ESIHT system and provides a pathway-specific mapping of the TRXAS signal to facilitate the interpretation of future experiments.
Co-Crystallization Induced Spontaneous Deracemization: A General Innovative Thermodynamic Approach to Deracemization.
Authors: guillot michael , demeester josephine , huynen sarah , collard laurent , robeyns koen , riant olivier , Leyssens Tom
Published: February 2020

Processes leading to enantiopure compounds are of utmost importance, in particular for the pharmaceutical industry. Starting from a racemic mixture, Crystallization Induced Diastereomeric Transformation allows for a theoretical 100% transformation of the desired enantiomer. However, this method has the inherent limiting requirement for the organic compound to form a salt. In this contribution, this limitation is lifted by introducing cocrystallization in the context of thermodynamic deracemization, with the process applied to a model chiral fungicide. We here report a new general single thermodynamic deracemization process based on co-crystallization for the deracemization of (R,S)-4,4-dimethyl1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-Pentan-3-one. This work presents the feasibility of this novel approach and paves the way to further development of such processes.
Transglutaminase 2 mediates hypoxia-induced selective mRNA translation via polyamination of 4EBPs
Authors: Cho Sung-Yup , Lee Seungun , Yeom Jeonghun , Kim Hyo-Jun , Lee Jin-Haeng , Shin Ji-Woong , Kwon Mee-ae , Lee Ki Baek , Jeong Eui Man , Ahn Hee Sung , Shin Dong-Myung , Kim Kyunggon , Kim In-Gyu
Published: February 2020

Hypoxia selectively enhances mRNA translation despite suppressed mammalian target of rapamycin complex 1 activity, contributing to gene expression reprogramming that promotes metastasis and survival of cancer cells. Little is known about how this paradoxical control of translation occurs. Here, we report a new pathway that links hypoxia to selective mRNA translation. Transglutaminase 2 (TG2) is a hypoxia-inducible factor 1–inducible enzyme that alters the activity of substrate proteins by polyamination or crosslinking. Under hypoxic conditions, TG2 polyaminated eukaryotic translation initiation factor 4E (eIF4E)-bound eukaryotic translation initiation factor 4E-binding proteins (4EBPs) at conserved glutamine residues. 4EBP1 polyamination enhances binding affinity for Raptor, thereby increasing phosphorylation of 4EBP1 and cap-dependent translation. Proteomic analyses of newly synthesized proteins in hypoxic cells revealed that TG2 activity preferentially enhanced the translation of a subset of mRNA containing G/C-rich 5′UTRs but not upstream ORF or terminal oligopyrimidine motifs. These results indicate that TG2 is a critical regulator in hypoxia-induced selective mRNA translation and provide a promising molecular target for the treatment of cancers.
Glycemic index and glycemic load of arrowroot (Maranta arundinaceae) cookies with the addition of cinnamon (Cinnamomum verum) and porang (Amorphophallus oncophyllus) glucomannan
Authors: Lestari L.A. , Gama D.B. , Huriyati E. , Prameswari A.A. , Harmayani E.
Published: February 2020

Development of functional food especially diabetic food has recently increased since the
prevalence of type 2 diabetes mellitus has increased dramatically. Hence, we developed
My Cookies® that made from several ingredients that could lower the blood glucose
namely arrowroot (Maranta Arundinaceae), cinnamon (Cinnamomum verum), and porang
(Amorphophallus oncophyllus) glucomannan. The objective of this study was to evaluate
the nutrient composition, glycemic index, and glycemic load of My Cookies®. Cookie
samples were analyzed for their nutrient composition using proximate analysis methods.
The total sugar and total starch of cookies were analyzed with colorimetric method and
enzymatic method, respectively, while dietary fiber and resistant starch were analyzed
with enzymatic-gravimetric method. The glycemic index and glycemic load were
determined using Wolever and Jenkins method. The result showed that the cookies
contain water, ash, protein, fat, total carbohydrate, soluble fiber, insoluble fiber, and
resistant starch as much as 7.20%, 2.66%, 7.66%, 28.00%, 54.49%, 0.57%, 15.80% and
2.23% respectively. Glycemic index and glycemic load of the cookies were 48.2 and 6.92
respectively. Since the glycemic index and glycemic load were categorized as low, it can
be concluded that My Cookies® could be consumed by diabetics as an alternative snack.
The dilatation factor of left atrium in remote period after the mitral valve prosthesis
Authors: Pukas K. V. , Lazoryshynets V. V.
Published: February 2020

Objective. Studying of the morphometry indices and contractility of the heart left compartments in the left atrium reduction after prosthesis of a mitral valve.

Materials and methods. Into the investigation 634 consequently operated patients with isolated mitral failure were included, who were surgically treated in Amosov National Institute of Cardiovascular Surgery from the 1st of January to the 1st of January 2007 yr. In all the patients the mitral valve prosthesis was performed. In the left atrium dilatation in 49 (7.7%) patients additionally its reduction was done, using paraanular plication of posterior wall of left atrium with the aim to achieve its size lesser than 5,0 cm.

Results. Of 49 patients, suffering constant form of atrial fibrillation, thromboembolic complications have occurred in 3 (6.1%) while performance of paraanular plasty of left atrium with simultaneous elimination of its auricle. All thromboembolic complications were nonsevere, and a left atrium size did not exceeded 5.5 sm.

Conclusion. The left atrium reduction and elimination of its auricle in the left-sided atriomegaly constitutes a significant element of the result improvement in the mitral valve prosthesis in late period of follow-up.
Diagnostic system of determination of an acute cholangitis
Authors: Mamontov I. N.
Published: February 2020

Objecive. To elaborate a diagnostic system, permitting to confirm or exclude the diagnosis of an acute cholangitis in patients, suffering biliary ducts obstruction.
Materials and methods. The wok is based on analysis of clinical, laboratory and instrumental indices in 174 patients, suffering the biliary ducts obstruction (in 18 - with an acute cholangitis).
Results. The diagnostic system was constructed, taking into account informativity of such indices, as ratio of the segmented and stab neutrophils quantity, quantity of stab neutrophils, bilirubin, a gallbladder wall thickness, quantity of monocytes, leukocytes, the Charcot’s triad presence, the body temperature, level of amylase, the duodenal papilla magna size, quantity of lymphocytes, presence of excluded gallbladder, presence of cholecystectomy in anamnesis, the immobile calculus of duodenal papilla magna, tumor, the eosinophils quantity, as well as the presence of any choledocholithiasis and age.
Conclusion. The elaborated diagnostic scheme for determination of an acute cholangitis in patients, suffering biliary ducts obstruction, owes high security (≥ 95%), because the part of failed diagnosis did not exceeded 5% and have constituted 2.8%.
Early peroral feeding after pancreaticoduodenecomy
Authors: Skums A. V. , Kuzmenko V. O. , Skums A. A. , Prysyazhna N. R.
Published: February 2020

Objective. To analyze the various ways for enteral feeding after pancreaticoduodenectomy.
Materials and methods. There were investigated the results of pancreaticoduodenectomy, performed in 78 patients, suffering tumors of pancreatic head and periampullary zone, in whom various methods of nutritive support, in 2003 - 2017 yrs were applied. For comparative analysis the patients were divided into two groups: the first - 39 patients, perioperative treatment of whom was conducted in accordance to the ERAS program, and the second - 39 patients, who were treated using a standard method. In patients of the first group the effects of a peroral way of nutrition were compared, as well as combined peroral and enteral nutrition via microjejunostomy. There were studied the terms of restoration of peroral feeding, the gastrostasis rate, the nutrition calorage during 7 postoperative days, levels of general protein and albumin on the first, third and seventh postoperative day.
Results. In 33 (84.6%) patients of the first group the peroral nutrition restoration have occurred in complete order to the protocol. The gastrostasis rate in patients of the first group was essentially lesser, than in patients of the second group. In the first group this complication have occurred in 6 (15.4%) patients, in the second group - in 14 (35.9%) patients (p = 0.009). Dynamics of level of general protein and albumin of the blood in postoperative period did not depend on method and energetic estimate of the nutrition.
Conclusion. Application of peroral feeding, in accordance to the concept of the program for accelerated restoration of the patients, survived after pancreaticododenectomy, constitutes an optimal way for the nutrient support of an organism and permits to reduce the gastrostasis rate trustworthily.
Prophylaxis of complications after radical operations in patients, suffering a mammary gland cancer
Authors: Vinnyk Yu. O. , Vlasenko V. G. , Baranova A. V.
Published: February 2020

Objective. Elaboration of prophylactic measures for complications after radical operations in patients, suffering mammary gland cancer, and estimation of its efficacy.
Materials and methods. Immediate results of surgical treatment were analyzed in 147 patients, suffering mammary gland cancer, and distributed, depending on perioperative treatment methods, into: the1st (comparison group) - 92 women-patients, to whom a standard treatment was applied, the second one (main group) - 55 women-patients, in whom complex of prophylactic measures was applied, including organizational, as well as compressive and medicinal therapy.
Results. Application of complex of prophylactic measures was accompanied by reduction of the development rate of postoperative oedema from 50% (comparison group) to 25% (p=0.003), the seroma’s formation - from 29 to 11% (p=0.010), development and severity of postmastectomy syndrome, lymphorrhea - from 29 to 18% (p=0,131) and the wounds complications - from 25 to 7.3% (p=0.007).
Conclusion. After radical operations with the lymph node dissection in patients, suffering mammary gland cancer, the early morbidity rate is rather high, and mainly connected with lymphovenous drainage outflow. The complex of measures, aiming at minimization of the patients’ stationary stay, early extraction of draining tubes, early activation of the patients, the improved compressive and medicinal therapy permits to reduce the rate and severity of morbidity and to accelerate the patients’ recovery and reconvalescence.
Possibilities of performance of nonstandard operative interventions in patients, suffering early gastric cancer
Authors: Grubnik V. V. , Grubnik Yu. V. , Nikitenko R. P.
Published: February 2020

Objective. To study a possibility of performance of nonstandard organ-preserving operations in patients, suffering early gastric cancer, using application of the sentinel lymph nodes visualization procedures and the lymph node dissection procedure.
Materials and methods. There were performed operative interventions in 35 patients, suffering early gastric cancer (Stages T1 and T2). For identification of sentinel lymph nodes a procedure of luminescence, using green indocyan, was applied.
Results.  In all the patients early gastric cancer was diagnosed (T1,T2). Possibility for performance of organ-preserving operations in early gastric cancer was shown. Miniinvasive interventions in a patient with severe concurrent diseases have appeared sufficiently effective and radical. The patients’ quality of life after laparoscopic pylorus-preserving and organ-preserving operations was significantly better, than quality of life in patients, to whom gastric resection with extended D2 lymph node dissection was done.
Conclusion. There was established, that intraoperative lymphography constitutes he informative method, which helps to estimate the disease Stage in gastric cancer and to apply the adequate scheme of combined and complex treatment. More sensitive is a procedure of luminescence, using green indocyan. Determination of the affection degree of «sentinel lymph nodes» in gastric cancer may serve as an argument for change of the selection tactics while changing the tactics for the operative intervention volume choice.
Studying of capacity of the inflamed intestinal wall to accumulate tienam preparation in experiment
Authors: Nepomniashchyi V. V.
Published: February 2020

Objective. Using experimental pattern of mechanical ileus, to study the capacity of nonchanged and inflamed intestine to accumulate a tienam preparation.
Materials and methods. The experiment was conducted on 60 laboratory animals in two stages. On the first stage the content of tienam in the blood, parenchymatous organs and in the nonchanged intestinal wall was determined. On the second stage the content of the tienam components was determined in the blood, parenchymatous organs and in the wall of inflamed suprastenotic part of intestine. In both series the preparation was injected intravenously in accordance to scheme, calculated for the animals body mass. The quantity of tienam preparation in the investigated material was determined, using the method of a highly effective liquid chomatography.
Results. The experimental investigation conducted have shown, that the tienam preparation components in nonoperated animals are accumulated in therapeutic doses in the blood, liver and kidneys. In the animals, in whom mechanical ileus was simulated, he tienam components were revealed only in parenchymatous organs and in the blood. In the inflamed intestinal wall the tienam components were not revealed even while injection of a dose, prevailing a middle therapeutic one  in 2.5 times.
Conclusion. Imipenem and cilastatin, which are included into tienam preparation, while secondary injections in a dose, prevailing a middle therapeutic one  in 2.5 times, were not revealed in the wall of the inflamed intestine in experimental mechanical ileus.
“I wish I had kept on looking back then”: The issue of epistolary communication in the film "The Lunchbox" (2013)
Authors: Harenda Olivier
Published: February 2020

The article examines the way in which a thread of communication is formed between two people from seemingly the same cultural background, but who differ in terms of age, gender, religion, and personal experiences. The analysis is done on the basis of the movie titled “The Lunchbox” (2013). Firstly, the article provides introductory information about the film. Next, culture-specific and historical information is presented so as to correctly establish the characteristics of the main protagonists. Then, the issue of the formation of epistolary communication is examined on the basis of objects from the film. Finally, the article proceeds to an analysis of the conversation-through-letters by exploring the personalities of the protagonists through the concepts of sentimentalism and individuality. The analysis aims to show that even in modern-day representations, the mode of epistolary contact is still popular and can also lead to new reinventions within the field of postcolonialism.
Comparison Analysis of K-Nearest Neighbor and Naïve Bayes in Determining Talent of Adolescence
Authors: Jusman Yessi , Rahmalina Widdya , Zarman Juni
Published: February 2020

Adolescence always searches for the identity to shape the personality character. This paper aims to use the artificial intelligent analysis to determine the talent of the adolescence. This study uses a sample of children aged 10-18 years with testing data consisting of 100 respondents. The algorithm used for analysis is the K-Nearest Neigbor and Naive Bayes algorithm. The analysis results are performance of accuracy results of both algorithms of classification. In knowing the accurate algorithm in determining children's interests and talents, it can be seen from the accuracy of the data with the confusion matrix using the RapidMiner software for training data, testing data, and combined training and testing data. This study concludes that the K-Nearest Neighbor algorithm is better than Naive Bayes in terms of classification accuracy.
ANALISIS DAMPAK EKONOMI PEDAGANG KAKI LIMA DI KOTA BOGOR DENGAN PENDEKATAN INPUT OUTPUT ANALYSIS
Authors: Prasetya Syarief Gerald , Wardhani Yustiana
Published: February 2020

ABSTRACTA very high jobless people in the city has created an informal sector. This informal sector has become an alternative way for them to find a job. It has happened since it is very relatively easy joining or leaving this informal sector as there is not any particular regulation required. This research aims to study the contribution of street stalls upon the multiplier output, revenue, employment and forward-backward linkage over the economy. Method of analysis has been using input-output analysis and the research location has taken place in Bogor. The result of the research has indicated that the availability of the street stalls in the city cannot be considered as a marginal sector as they have been contributing positively the city economy either in the multiplier analysis or forward-backward linkage. Organizing and registering the street stalls in Bogor should have to be executed properly and periodically in order to find out their economical potential, making sure that they will not jeopardize the landscape of public facility. However, a particular association should have to be established in order to ease the supervision of the street stalls and to improve their quality accordingly.Keyword : Street stalls, informal sector, output, revenue, manpowerABSTRAKTingginya tingkat pengangguran perkotaan menumbuhkan sektor informal. Pedagang kaki lima merupakan salah satu sektor informal menjadi alternatif bagi mereka yang tidak mendapatkan pekerjaan disebabkan mudahnya untuk masuk dan keluar di sektor informal relatif mudah karena tidak ada aturan secara khusus yang mensyaratkan. Penelitian ini bertujuan untuk mengetahui kontribusi pedagang kaki lima terhadap multiplier output, pendapatan, penyerapan tenaga kerja dan forward-backward linkage terhadap perekonomian. Metode analisis yang digunakan adalah analisis input-output dan lokasi penelitian di Kota Bogor. Hasil penelitian menunjukan keberadaan pedagang kaki lima perkotaan tidak dapat dipandang sebagai sektor yang marginal, pedagang kaki lima memberikan kontribusi positif terhadap perekonomian perkotaan baik dalam analisis multiplier dan analisis forward-backward linkage. Penataan dan pendataan pedagang kaki lima di Kota Bogor perlu dilakukan secara periodik agar dapat diketahui potensi ekonomi, tidak mengganggu landscap dan peruntukan fasilitas umum kota. Perlunya pembentukan assosiasi agar dapat lebih mudah dalam pengawasan dan upaya peningkatan kualitas pedagang kaki lima.Kata Kunci : Pedagang Kaki Lima, Sektor Informal, Output, Pendapatan, Tenaga Kerja
PENGARUH KONSENTRASI PVA TERHADAP ANALISA MERKURI MENGGUNAKAN METODE SPEKTROFOTOMETRI UV-VIS
Authors: Dewi Listiyana Candra
Published: February 2020

Not all mercury complex compounds can be stable for a long time. Some require additional stabilizers to keep mercury concentrations in the sample unchanged due to interference from outside factors such as measurement time, temperature, humidity, and light. One of the stabilizing compounds commonly used in the analysis of complex compounds is Polyvinyl Alcohol (PVA). Addition of certain substances in the sample solution will have an influence on the character of the sample solution. In this article we will discuss the effect of PVA concentration on the results of analysis of mercury iodide-rhodamine B complex using a UV-Vis spectrophotometer method. The research in this article is experimental. Measurements are made by changing the Hgcation2+ to anion [HgI4]2-. The anion was reacted with rhodamine B and PVA compounds with varying concentrations, then analyzed using a UV-Vis spectrophotometer. The presence of mercury in solution gives rise to new peaks in the wavelength range of 592-606 nm. The concentration of PVA added as a stabilizing agent affects the measurement results. The more concentrated PVA concentration is used, the lower the peak of the mercury iodide-Rhodamine B complex on the spectrum.