bluuebunny/crossref_metadata_2025 huggingface dataset:
Trends in Urban Wild Meat Trade of Chelonians (Turtles and Tortoises) in the Peruvian Amazon
Authors: Mayor Pedro , Bodmer Richard , Moya Kelly , Solis Samantha , Kirkland Maire , Perez-Peña Pedro , Fang Tula , Orta-Martínez Martí
Published: November 2024

Culturally, chelonians are important sources of nutrition and income for rural and urban people in tropical rainforests, but urban trade can cause declines in wild populations. This study analyses the urban chelonian trade and its trends to better understand the impact on free-living populations in the Northern Peruvian Amazon. We studied the urban trade of wild chelonians by conducting 526 days of participant observation and structured questionnaires with the main chelonian vendors in the wet markets of Iquitos between 2006 and 2018. The trade of chelonians decreased by −161.6%, from 22,694 individuals in 2006/07 to 8657 individuals in 2017/18. Chelonoidis denticulatus was the species sold the most (86.3%), followed by Podocnemis unifilis (13.6%). Podocnemis expansa was only sold in 2006/07. River turtle sales increased in the dry season, while sales of Chelonoidis denticulatus decreased. Turtles were the most expensive meat sold in urban markets: 49.7% more expensive than the most frequently consumed fish, Prochilodus nigricans, and 48.4% more expensive than poultry. Turtles represented only 0.19% (SD 0.23) of the index of domestic meat and fish consumption per capita. River turtle eggs are sold by a different set of vendors, and in 2017/18, 570,229 eggs were traded in the market of Belén in Iquitos, equivalent to an approximate lay of 10,418 P. unifilis and 1178 P. expansa females. The high magnitude of the trade of river turtle eggs together with the reduction in their meat trade suggests a prioritization of egg sales, which should improve the conservation of adults, since meat sales can be detrimental to chelonian populations.
Effect of Integrated Crop–Livestock Systems on Soil Properties and Microbial Diversity in Soybean Production
Authors: Sinha Namita , Rushing Brett R. , Acharya Aniruddha , Ganapathi Shanmugam Shankar
Published: November 2024

Integrated crop and livestock systems (ICLSs) have been considered an important management-based decision to improve soil health by carbon sequestration. A two-year study (2019–2021) at CPBES in Newton, MS, was conducted to evaluate the effect of an ICLS on soil microbial diversity in the southeastern region of the USA, representing agroclimatic conditions that are warm and humid. Amplicons targeting bacterial 16S rRNA genes and fungal ITS2 regions were sequenced. Taxonomic assignment and characterization of microbial diversity were performed using QIIME2®. Soil fungal diversity pattern showed significant difference (alpha diversity, p = 0.031 in 2020 and beta diversity, p = 0.037 in 2021). In contrast, no significant differences were observed in bacterial diversity. However, there were several beneficial bacterial phyla, such as Proteobacteria and Actinobacteria, and fungal phyla such as Ascomycota, which were dominant in both years and did not show significant differences due to cover crop treatments. Canonical Correspondence Analysis (CCA) and Mantel test showed significant influence on fungal diversity due to carbon (rm = 0.2581, p = 0.022), nitrogen (rm = 0.2921, p = 0.0165), and electrical conductivity (rm = 0.1836, p = 0.0583) in 2021, and on bacterial diversity due to EE-GRSP (rm = 0.22, p = 0.02) in 2020. However, the results showed that there were no significant differences between the cover crop treatments that were consistent over a two-year study period. However, the mix of different cover crops such as oats (Avena sativa L.), crimson clover (Trifolium incarnatum L.), and tillage radish (Raphanus sativus L.) demonstrated higher positive correlation and lower negative correlation with different bacterial and fungal phyla. Long term study of ICLS is suggested to understand the shift in microbiome that would help in understanding the role of cover crops and grazing in improving crop production sustainably.
Air–Bone Gap in Meniere’s Disease: A Case Series and Literature Review
Authors: Pajaniappane Arun , Parekh Nilesh , Wong Anita
Published: November 2024

Background/Objectives: An air–bone gap (ABG) on audiometry is usually secondary to a conductive hearing loss. However, persistent and repeatable ABGs on audiometry in the absence of external or middle ear pathology is thought to arise from inner ear disorders including Meniere’s Disease (MD). In this paper, we aim to showcase this interesting finding occurring in MD with an associated literature review. Methods: Using retrospective review and analysis of case notes, we describe eight cases of persistent ABG on audiometry in MD. All other causes for the ABG were explored and excluded with the aid of objective audiological testing. Results: ABG can occur in a small sub-set of the MD population. In our case series, the ABG was typically found to affect the low frequencies. Higher frequencies appear to be spared. However, a detailed history, examination and battery of objective tests are required to ensure that all other causes of the ABG are reliably considered and excluded prior to attributing it to the inner ear. The finding of an ABG in MD may be dependent on the stage of the disease. Further research is required to determine the underlying cause of the ABG and its potential applications to help guide treatment.
Advancing Circular Economy in Olive Oil Production: Comparing Maturation Systems for Vermicompost Creation from Olive Pomace
Authors: Angeloni Giulia , Spadi Agnese , Corti Ferdinando , Calcaprina Marco , Carpi Giulia , Maioli Francesco , Parenti Alessandro , Masella Piernicola
Published: November 2024

The production of extra virgin olive oil (EVOO) creates by-products like olive pomace, which brings environmental issues due to its strong odors and the challenges involved in storage. To address this within a circular economy framework, this study explores the potential of olive pomace as a nutrient source for earthworms, aiming to transform it into a beneficial soil amendment. Key nutrients in the pomace, such as polyphenols, sugars, and organic matter, were examined for their effectiveness in nourishing earthworms. Four distinct treatments were applied to the pomace: mechanical mixing, aeration, a combination of both, and no treatment. For a period of 30 days, chemical parameters including pH, polyphenol levels, and moisture content were monitored, while earthworm preferences were assessed at Centro Lombricoltura Toscano (CLT). The study revealed significant differences in the chemical composition of the pomace depending on the treatment, especially regarding polyphenol and total sugar content. These changes influenced the palatability for earthworms, with the combined treatment producing the most appealing pomace, likely due to the increased nutrient availability. Ultimately, olive pomace has promising potential to be repurposed into a nutrient-dense soil amendment, alleviating environmental concerns and contributing to more sustainable waste management within the olive oil industry.
Different Markers of Semantic–Lexical Impairment Allow One to Obtain Different Information on the Conversion from MCI to AD: A Narrative Review of an Ongoing Research Program
Authors: Quaranta Davide , Marra Camillo , Vita Maria Gabriella , Gainotti Guido
Published: November 2024

Background: In this narrative review, we have surveyed results obtained from a research program dealing with the role of semantic memory disorders as a predictor of progression from mild cognitive impairment (MCI) to Alzheimer’s disease (AD). Objectives: In this research program, we have taken into account many different putative markers, provided of a different complexity in the study of the semantic network. These markers ranged from the number of words produced on a semantic fluency task to the following: (a) the discrepancy between scores obtained on semantic vs. phonemic word fluency tests; (b) the presence, at the single-word level, of features (such as a loss of low typical words on a category verbal fluency task) typical of a degraded semantic system; or (c) the presence of more complex phenomena (such as the semantic distance between consecutively produced word pairs) concerning the organization of the semantic network. In the present review, all these studies have been presented, providing separate subsections for (a) methods, (b) results, and (c) a short discussion. Some tentative general conclusions have been drawn at the end of the review. We found that at baseline all these markers are impaired in MCI patients who will later convert to AD, but also that they do not necessarily show a linear worsening during the progression to AD and allow one to make different predictions about the time of development of AD. Our conclusions were that, rather than searching for the best marker of conversion, we should use a range of different markers allowing us to obtain the information most appropriate to the goal of our investigation.
Annexin A2 in Tumors of the Gastrointestinal Tract, Liver, and Pancreas
Authors: Christofidis Konstantinos , Pergaris Alexandros , Fioretzaki Rodanthi , Charalampakis Nikolaos , Kapetanakis Emmanouil Ι. , Kavantzas Nikolaos , Schizas Dimitrios , Sakellariou Stratigoula
Published: November 2024

Annexin A2 (ANXA2) is a protein that is involved in many physiological and pathological cellular processes. There is compelling evidence that its dysregulated expression, be it up- or downregulation, contributes to the oncogenesis of various neoplasms, including those of the digestive system. The present review summarizes the current knowledge on the role of ANXA2 in the main tumors of the digestive system. The clinical significance of ANXA2 is primordial, due to its potential use as a diagnostic and prognostic biomarker, and as a part of therapeutic protocols. Certain preclinical studies have shown that inhibiting ANXA2 or disrupting its interactions with key molecules can suppress tumor growth, invasion, and metastasis, as well as increase the cancer cells’ sensitivity to treatment in various cancers. Further research is needed to fully elucidate the complex role of ANXA2 in the carcinogenesis of tumors of the digestive system, and to translate these findings into clinical applications for improved diagnosis, prognosis, and treatment.
Gastric Epithelial Polyps: Current Diagnosis, Management, and Endoscopic Frontiers
Authors: Reyes-Placencia Diego , Cantú-Germano Elisa , Latorre Gonzalo , Espino Alberto , Fernández-Esparrach Glòria , Moreira Leticia
Published: November 2024

Polyps are defined as luminal lesions that project into the mucosal surface of the gastrointestinal tract and are characterized according to their morphological and histological features [...]
miR-29a Downregulates PIK3CA Expression and Inhibits Cervical Cancer Cell Dynamics: A Comparative Clinical Analysis
Authors: Jeong Hyorim , Choi Kangchan , Hwang Dasom , Park Sunyoung , Park Yong Serk , Lee Hyeyoung
Published: November 2024

HPV/pap tests are widely used for cervical cancer screening, playing a crucial role in early diagnosis and guiding future treatment options. However, approximately 50% of cervical cancer patients are diagnosed at an advanced stage, which is associated with higher recurrence rates and poorer survival outcomes than early-stage diagnoses. This underscores the need for effective treatments for advanced-stage cervical cancer. Among the various oncogenes implicated in cancer, PIK3CA expression is known to cause cervical cancer, suggesting that inhibiting PIK3CA may impede cervical cancer progression. In this study, we transfected PIK3CA-overexpressing tumor cells (SiHa, C33A, and HeLa) with miR-29a, a microRNA extensively studied as a therapeutic candidate for oncogene suppression in various tumor types. We conducted RT-qPCR and Western blot analyses to assess changes in PIK3CA expression at the RNA and protein levels. Wound healing and cell migration assays were used to evaluate the effects of miR-29a on cell division and migration in HeLa cells. We confirmed a reduction in PIK3CA expression at both RNA and protein levels following miR-29a transfection. After transfecting miR-29a into HeLa cells, we observed a reduction in cell division and migration, as demonstrated by wound healing and cell migration assays. Additionally, we found that miR-29a binds to the 3′-UTR region of PIK3CA, leading to a reduction in its gene expression. Furthermore, we correlated the concentration of miR-29a in clinical histologic biopsy samples from cervical cancer patients with disease progression. These findings indicate that miR-29a can slow the progression of cervical cancer by targeting PIK3CA and potentially aid in its treatment. miR-29a shows promise as a therapeutic agent for inhibiting oncogene expression and controlling cervical cancer progression, especially in advanced-stage cases.
Construction of a Carbon Monoxide-Releasing Bioactive Hydrogel Coating on the Magnesium Alloy Surface for Better Corrosion Resistance, Anticoagulant Properties, and Endothelial Cell Growth
Authors: Gao Renwei , Meng Lingjie , Pan Changjiang
Published: November 2024

In this study, we first fabricated a crosslinked hydrogel coating by polymerizing methacryloyloxyethyl sulfonyl betaine and acrylamide (SBMA) on the magnesium (Mg) alloy surface employing ultraviolet (UV) polymerization. Bivalirudin and CO-releasing molecules (CORM-401) were further grafted onto the hydrogel coating surface to acquire a multifunctional biocompatible coating capable of releasing CO to augment corrosion-resisting properties and biocompatibility. The findings verified that the bioactive hydrogel coating significantly increased the corrosion potential and reduced the corrosion current, thereby improving the anticorrosion performance. Meanwhile, owing to the excellent hydrophilicity, the antifouling performance of the hydrogel coating, and the excellent anticoagulant performance of bivalirudin, the hydrogel coating significantly reduced the fibrinogen adsorption, platelet adhesion and activation, and hemolysis occurrence, displaying excellent ability to inhibit blood clotting. Moreover, endothelial cell (EC) experimental results demonstrated that the hydrogel coating could significantly promote EC growth, displaying great potential to induce re-endothelialization after implantation. Specifically, in the presence of cysteine capable of catalyzing CO release, the anticoagulant performance and ability to promote EC growth were further improved significantly. Therefore, the study offers an effective strategy to prepare a hydrogel coating capable of releasing CO to improve the corrosion-resisting performance and biocompatibility of Mg alloys, which is anticipated to be applied in the surface modification of Mg alloy intravascular stents.
Challenges and Opportunities in Establishing a COVID-19 Patient Registry in a Regional Setting in the Philippines
Authors: Dumancas Gerard G. , Generalao Oliver B. , Rivera Hans Carlo E. , Zamora-Rico Pia Regina Fatima , Rico Jonathan Adam A. , Climacosa Fresthel Monica M. , Caoili Salvador Eugenio C. , de Castro Romulo
Published: November 2024

The purpose of this review is to evaluate various challenges and opportunities as well as propose solutions for the development and implementation of a prospective COVID-19 patient registry within a regional context in the Philippines. To comprehensively study the course of COVID-19 in the Philippine population, it is essential to develop a comprehensive dataset that includes relevant treatment and diagnostic information. While individual patient reports related to the disease are available at various institutions in the Philippines, there is a need for a more extensive and representative database to facilitate robust analysis. The primary clinical objective of establishing a COVID-19 patient registry was to enhance the accuracy of disease diagnosis. In this review, we present a comprehensive explanation of the systematic rationale, design, and execution of a COVID-19 patient registry in the Western Visayas region of the Philippines. Based on this review, several factors exist that hinder the implementation of a COVID-19 patient registry in this regional setting in the Philippines, including lack of funding, facilities, infrastructure, manpower, and expertise, and unwillingness of some hospitals to pursue research. We also discussed herewith the proposed program implementation for the establishment of such a registry in a regional setting in the Philippines.
The Structure and Optical Properties of Luminescent Terbium Terephthalate Metal–Organic Frameworks Doped with Yttrium, Gadolinium, and Lanthanum Ions
Authors: Petrova Anna S. , Butorlin Oleg S. , Toikka Yulia N. , Kolesnikov Ilya E. , Orlov Sergey N. , Ryazantsev Mikhail N. , Bogachev Nikita A. , Skripkin Mikhail Yu. , Mereshchenko Andrey S.
Published: November 2024

The structural features and luminescent properties of heterometallic Tb–Gd, Tb–La, and Tb–Y terephthalate metal–organic frameworks, namely (TbxM1−x)2(1,4-bdc)3∙4H2O (M = Gd, La, Y), were studied in detail in a wide concentration range (x = 0.001–1). The crystalline phase of synthesized compounds corresponds to Ln2(1,4-bdc)3·4H2O. The lifetime of 5D4 decreased with increased Tb3+ concentration, but PLQY depends non-linearly on the Tb3+ concentration. The 50% substitution of Tb3+ for Y3+, Gd3+, or La3+ ions result in the significant enhancement of photoluminescence quantum yield, up to 1.6 times. The morphology, thermal stability, and vibrational structure of the selected homo- and bi-metallic materials is reported as well.
Matching Analysis of Technical Parameters and Safety Standards for Nuclear Replacement of Coal-Fired Units
Authors: Zhang Dongwang , Zhou Tuo , Liu Zhihong , Yang Hairui , Bie Rushan , Zhang Man
Published: November 2024

In the context of the growing share of renewable energy and the impending decommission of a large number of coal-fired units, nuclear energy is the only green energy that can replace coal power for a stable, clean, efficient, and large-scale power supply. This article compares the differences between coal power and nuclear power in terms of thermal system, thermal cycle, turbine parameters, and safety. It discusses the possibility of replacing the boiler of a coal power plant with nuclear power, that is, replacing the boiler of a coal power plant with a nuclear reactor for generation/heating/cogeneration. For coal-fired units with similar capacity that do not use a reheat cycle (at or below high pressure) and nuclear power units (such as a high-temperature gas-cooled reactor), as well as coal-fired units with a reheat cycle (ultra-high pressure and above) and nuclear power units (such as pressurized water reactors), there are great differences in steam parameters. In terms of steam turbines, the size of nuclear power units is relatively larger, requiring additional dehumidification measures. In addition, the safety factors and management methods considered in the site selection, construction, and operation of nuclear power plants are more stringent and complex, and comprehensive analysis and evaluation are needed in aspects such as waste treatment and accident emergency response. Except for the relevant provisions of the American Society of Mechanical Engineers code for pressure vessels, nuclear power units are not compatible with coal-fired units in terms of safety standards. Therefore, considering comprehensively, it is believed that the scheme of nuclear power replacing coal-fired units for power generation/heating/cogeneration program is not feasible at present.
The Gasification and Pyrolysis of Biomass Using a Plasma System
Authors: Messerle Vladimir E. , Ustimenko Alexandr B. , Lavrichshev Oleg A. , Nugman Marina K.
Published: November 2024

This research paper analyzes the use of plasma technology to process biomass in the form of dried, mixed animal manure (dung containing 30% moisture). The irrational use of manure as well as huge quantities of it can negatively impact the environment. In comparison to biomass fermentation, the plasma processing of manure can greatly enhance the production of fuel gas, primarily synthesis gas (CO + H2). The organic part of dung, including the moisture, is represented by carbon, hydrogen, and oxygen with a total concentration of 95.21%, while the mineral part is only 4.79%. A numerical analysis of dung plasma gasification and pyrolysis was conducted using the thermodynamic code TERRA. For 300–3000 K and 0.1 MPa pressure, the dung gasification and pyrolysis were calculated with 100% dung + 25% air and 100% dung + 25% nitrogen, respectively. Calculations were performed to determine the specific energy consumption of the process, the composition of the products of gasification, and the extent of the carbon gasification. At 1500 K, the dung gasification and pyrolysis consumed 1.28 and 1.33 kWh/kg of specific energy, respectively. A direct-current plasma torch with a power rating of 70 kW and a plasma reactor with a dung processing capacity of 50 kg/h were used for the dung processing experiments. The plasma reactor consumed 1.5 and 1.4 kWh/kg when pyrolyzing and gasifying the dung. A maximum temperature of 1887 K was reached in the reactor. The plasma pyrolysis of dung and the plasma–air gasification of dung produced gases with specific heats of combustion of 10,500 and 10,340 kJ/kg, respectively. Calculations and experiments on dung plasma processing showed satisfactory agreement. In this research, exergy analysis was used to quantify the efficiency of the plasma gasification of biomass. One of the research tasks was to develop a methodology and establish standards for the further standardization of monitoring the toxic emissions of dioxins, furans, and Benzo[a]pyrene.
Species Mixing Improves Tree Growth and Timber Quality of Chinese Fir in Mixtures with Broad-Leaved Species in Central China
Authors: Yin Zaifang , Jiao Jiejie , Sun Honggang , Chen Jinhu
Published: November 2024

Mixed stands of tree species with complementary traits can modulate stand growth and timber quality. At the Fengshushan Forest Farm, mixtures of Chinese fir (Cunninghamia lanceolata (Lamb.) Hook.) with Liquidambar formosana Hance, Schima superba Gardner & Champ., Elaeocarpus sylvestris (Lour.) Poir., Cinnamomum camphora (L.) Presl, and Chinese fir monoculture were established. Differences in stand growth and timber quality among these mixtures were assessed and a test was conducted to evaluate the factors influencing the mixture effects. The average diameter at breast height, tree height, stand volume, and individual tree annual increment of mixtures generally exceeded those of Chinese fir monocultures but not necessarily those of broad-leaved monocultures. When the net interaction between species was complementary, overyielding in mixtures occurred (RPfir,bl > 0), which was influenced significantly by stand density, soil properties, and timber quality. The timber quality and wood production of Chinese fir were enhanced by mixture with some broad-leaved species, with reduced slenderness and knottiness in mixtures, and notable increases in medium- (average outturn rates of 56.13%) and large-diameter (11.71%) timber in C. lanceolata/C. camphora mixture. The growth and timber quality of Chinese fir are largely promoted when grown mixed with broad-leaved species. Overyielding at the stand level occurs where Chinese fir compensates for the underperformance of broad-leaved trees.
An Explainable Deep Learning-Enhanced IoMT Model for Effective Monitoring and Reduction of Maternal Mortality Risks
Authors: Saleh Sherine Nagy , Elagamy Mazen Nabil , Saleh Yasmine N. M. , Osman Radwa Ahmed
Published: November 2024

Maternal mortality (MM) is considered one of the major worldwide concerns. Despite the advances of artificial intelligence (AI) in healthcare, the lack of transparency in AI models leads to reluctance to adopt them. Employing explainable artificial intelligence (XAI) thus helps improve the transparency and effectiveness of AI-driven healthcare solutions. Accordingly, this article proposes a complete framework integrating an Internet of Medical Things (IoMT) architecture with an XAI-based deep learning model. The IoMT system continuously monitors pregnant women’s vital signs, while the XAI model analyzes the collected data to identify risk factors and generate actionable insights. Additionally, an efficient IoMT transmission model is developed to ensure reliable data transfer with the best-required system quality of service (QoS). Further analytics are performed on the data collected from different regions in a country to address high-risk cities. The experiments demonstrate the effectiveness of the proposed framework by achieving an accuracy of 80% for patients and 92.6% for regional risk prediction and providing interpretable explanations. The XAI-generated insights empower healthcare providers to make informed decisions and implement timely interventions. Furthermore, the IoMT transmission model ensures efficient and secure data transfer.
Enhancing Communication Security in Drones Using QRNG in Frequency Hopping Spread Spectrum
Authors: de Curtò J. , de Zarzà I. , Cano Juan-Carlos , Calafate Carlos T.
Published: November 2024

This paper presents a novel approach to enhancing the security and reliability of drone communications through the integration of Quantum Random Number Generators (QRNG) in Frequency Hopping Spread Spectrum (FHSS) systems. We propose a multi-drone framework that leverages QRNG technology to generate truly random frequency hopping sequences, significantly improving resistance against jamming and interception attempts. Our method introduces a concurrent access protocol for multiple drones to share a QRNG device efficiently, incorporating robust error handling and a shared memory system for random number distribution. The implementation includes secure communication protocols, ensuring data integrity and confidentiality through encryption and Hash-based Message Authentication Code (HMAC) verification. We demonstrate the system’s effectiveness through comprehensive simulations and statistical analyses, including spectral density, frequency distribution, and autocorrelation studies of the generated frequency sequences. The results show a significant enhancement in the unpredictability and uniformity of frequency distributions compared to traditional pseudo-random number generator-based approaches. Specifically, the frequency distributions of the drones exhibited a relatively uniform spread across the available spectrum, with minimal discernible patterns in the frequency sequences, indicating high unpredictability. Autocorrelation analyses revealed a sharp peak at zero lag and linear decrease to zero values for other lags, confirming a general absence of periodicity or predictability in the sequences, which enhances resistance to predictive attacks. Spectral analysis confirmed a relatively flat power spectral density across frequencies, characteristic of truly random sequences, thereby minimizing vulnerabilities to spectral-based jamming. Statistical tests, including Chi-squared and Kolmogorov-Smirnov, further confirm the unpredictability of the frequency sequences generated by QRNG, supporting enhanced security measures against predictive attacks. While some short-term correlations were observed, suggesting areas for improvement in QRNG technology, the overall findings confirm the potential of QRNG-based FHSS systems in significantly improving the security and reliability of drone communications. This work contributes to the growing field of quantum-enhanced wireless communications, offering substantial advancements in security and reliability for drone operations. The proposed system has potential applications in military, emergency response, and secure commercial drone operations, where enhanced communication security is paramount.
Will Public Health Emergencies Affect Compensatory Consumption Behavior? Evidence from Emotional Eating Perspective
Authors: Wang Yi-Fei , Wang Kai-Hua
Published: November 2024

This research examines the correlation between the COVID-19 pandemic and the desire to engage in compensatory consuming behaviors, specifically emphasizing emotional eating as a psychological coping strategy, particularly with respect to snacks and sweets. Conducting sentiment analysis by using a Natural Language Processing (NLP) method on posts from Sina Weibo, a leading Chinese social media platform, the research identifies three distinct phases of consumer behavior during the pandemic: anxiety, escapism, and compensatory periods. These stages are marked by varying degrees of emotional eating tendencies, illustrating a psychological trajectory from initial shock to seeking comfort through food as a means of regaining a sense of normalcy and control. The analysis reveals a notable increase in posts expressing a desire for compensatory consumption of snacks and sweets in 2020 compared to 2019, indicating a significant shift towards emotional eating amid the pandemic. This shift reflects the broader psychological impacts of the crisis, offering insights into consumer behavior and the role of digital platforms in capturing public sentiment during global crises. The findings have implications for policymakers, health professionals, and the food industry, suggesting the need for strategies to address the psychological and behavioral effects of natural disasters.
Bell vs. Bell: A Ding-Dong Battle over Quantum Incompleteness
Authors: Hall Michael J. W.
Published: November 2024

Does determinism (or even the incompleteness of quantum mechanics) follow from locality and perfect correlations? In a 1964 paper, John Bell gave the first demonstration that quantum mechanics is incompatible with local hidden variables. Since then, a vigorous debate has rung out over whether he relied on an assumption of determinism or instead, as he later claimed in a 1981 paper, derived determinism from assumptions of locality and perfect correlation. This paper aims to bring clarity to the debate via simple examples and rigorous results. It is first recalled, via quantum and classical counterexamples, that the weakest statistical form of locality consistent with Bell’s 1964 paper (parameter independence) is insufficient for the derivation of determinism. Attention is then turned to critically assess Bell’s appeal to the Einstein–Rosen–Podolsky (EPR) incompleteness argument to support his claim. It is shown that this argument is itself incomplete, via counterexamples that expose two logical gaps. Closing these gaps via a strong “counterfactual” reality criterion enables a rigorous derivation of both determinism and parameter independence, and in this sense justifies Bell’s claim. Conversely, however, it is noted that whereas the EPR argument requires a weaker “measurement choice” assumption than Bell’s demonstration, it nevertheless leads to a similar incompatibility with quantum predictions rather than quantum incompleteness.
Epigenetics in Heart Failure
Authors: Ho Jamie Sin Ying , Jou Eric , Khong Pek-Lan , Foo Roger S. Y. , Sia Ching-Hui
Published: November 2024

Heart failure is a clinical syndrome with rising global incidence and poor prognosis despite improvements in medical therapy. There is increasing research interest in epigenetic therapies for heart failure. Pathological cardiac remodelling may be driven by stress-activated cardiac signalling cascades, and emerging research has shown the involvement of epigenetic signals that regulate transcriptional changes leading to heart failure. In this review, we appraise the current evidence for the role of epigenetic modifications in heart failure. These include DNA methylation and histone modifications by methylation, acetylation, phosphorylation, ubiquitination and sumoylation, which are critical processes that establish an epigenetic pattern and translate environmental stress into genetic expression, leading to cardiac remodeling. We summarize the potential epigenetic therapies currently in development, including the limited clinical trials of epigenetic therapies in heart failure. The dynamic changes in the epigenome in the disease process require further elucidation, and so does the impact of this process on the development of therapeutics. Understanding the role of epigenetics in heart failure may pave the way for the identification of novel biomarkers and molecular targets, and facilitate the development of personalized therapies for this important condition.
Anti-Inflammatory Effects of SGLT1 Synthetic Ligand in In Vitro and In Vivo Models of Lung Diseases
Authors: Rumio Cristiano , Dusio Giuseppina , Cardani Diego , La Ferla Barbara , D’Orazio Giuseppe
Published: November 2024

Background. Several research findings suggest that sodium–glucose co-transporter 1 (SGLT1) is implicated in the progression and control of infections and inflammation processes at the pulmonary level. Moreover, our previous works indicate an engagement of SGLT1 in inhibiting the inflammatory response induced in intestinal epithelial cells by TLR agonists. In this study, we report the anti-inflammatory effects observed in the lung upon engagement of the transporter, and upon the use of glucose and BLF501, a synthetic SGLT1 ligand, for the treatment of animal models of lung inflammation, including a model of allergic asthma. Methods. In vitro experiments were carried out on human pneumocytes stimulated with LPS from Pseudomonas aeruginosa and co-treated with glucose or BLF501, and the production of IL-8 was determined. The anti-inflammatory effect associated with SGLT1 engagement was then assessed in in vivo models of LPS-induced lung injury, as well as in a murine model of ovalbumin (OVA)-induced asthma, treating mice with aerosolized LPS and the synthetic ligand. After the treatments, lung samples were collected and analyzed for morphological alterations by histological examination and immunohistochemical analysis; serum and BALF samples were collected for the determination of several pro- and anti-inflammatory markers. Results. In vitro experiments on human pneumocytes treated with LPS showed significant inhibition of IL-8 production. The results of two in vivo experimental models, mice exposed to aerosolized LPS and OVA-induced asthma, revealed that the engagement of glucose transport protein 1 (SGLT1) induced a significant anti-inflammatory effect in the lungs. In the first model, the acute respiratory distress induced in mice was abrogated by co-treatment with the ligand, with almost complete recovery of the lung morphology and physiology. Similar results were observed in the OVA-induced model of allergic asthma, both with aerosolized and oral BLF501, suggesting an engagement of SGLT1 expressed both in intestinal and alveolar cells. Conclusions. Our results confirmed the engagement of SGLT1 in lung inflammation processes and suggested that BLF501, a non-metabolizable synthetic ligand of the co-transporter, might represent a drug candidate for therapeutic intervention against lung inflammation states.
Twitter Economic Uncertainty and Herding Behavior in ESG Markets
Authors: Koutmos Dimitrios
Published: November 2024

Attention to environmental, social, and governance (ESG) investing has grown in recent years. Even after the SARS-CoV-2 (COVID-19) global pandemic, there has been a rise in financial instruments that are structured according to certain prescribed “sustainable finance” objectives. From a risk management perspective, and as we continue to see a rise in inflows into such instruments, it is important to appreciate that ESG markets will have a growing influence on our financial system and its development. In light of this, and using a sample of some of the most common and popular US-based ESG index funds, this study explores the extent to which herding behaviors are present in such markets. From a regulatory point of view, such behaviors are important to identify, given that they can lead to excess price volatility, bubbles, and other such market-destabilizing phenomena. In addition, this study builds a framework for exploring whether Twitter-based economic uncertainty, which is arguably a forward-looking indicator of investors’ expectations, can exacerbate herding behaviors in ESG markets. Overall, this study shows the following: (i) herding behaviors are present in ESG markets; (ii) rises in Twitter economic uncertainty can potentially exacerbate such herding; (iii) although ESG funds, like traditional asset classes, generally show a negative risk–return tradeoff, this can be driven by changes in Twitter economic uncertainty.
Are Medium-Sized Cities in China Shrinking from 2010 to 2020? An Empirical Analysis with a Multi-Dimensional Model
Authors: Gao Lei , Ye Chao , Zhuang Liang
Published: November 2024

Urban shrinkage has emerged as a worldwide concern, which is increasingly prevalent in developing countries like China, particularly in medium-sized cities (MSCs). Compared to large cities and counties, MSCs find themselves in a national policy blind spot and have been neglected both in policy and research. Previous studies, based on population changes, have shown that urban shrinkage in China is not severe. However, urban shrinkage is not just about population decline, and it has not been adequately discussed from a multi-dimensional perspective. This paper adopts a multi-dimensional model, considering population, economy, and space dimensions to analyze shrinkage patterns in 164 MSCs in China from 2010 to 2020. Findings reveal that 6.1% of MSCs experienced population shrinkage, and 24.4% faced shrinkage in economic or spatial dimensions. Shrinking MSCs are spatially distributed in the Northeast as well as in the areas surrounding large cities. Industrial restructuring, job losses, and healthcare disparities contribute to urban shrinkage, and the impact of aging will be further felt. As large cities consistently attract population and resources and digitization has dramatically affected population mobility, more MSCs will shrink in the future. This paper contributes to the understanding of shrinkage of MSCs among scholars and policymakers, urging a shift towards more balanced and digital urban governance.
Effect of Cerium Content on Non–Metallic Inclusions and Solidification Microstructure in 55SiCr Spring Steel
Authors: Tang Haiyan , Cai Sen , Lan Peng , Ma Yu , Wang Yuhang , Wang Kaimin
Published: November 2024

The effect of cerium content (0, 0.011, 0.017, 0.075 wt%) on non-metallic inclusions and solidification microstructures of 55SiCr high-strength spring steel was experimentally studied, along with thermodynamic calculations. The results show that Ce addition changes the type and size of inclusions in this steel and influences the characteristics of the solidification microstructure. In the sample without Ce addition, the main inclusions are MnS, SiO2, SiO2–MnS, and CaO–SiO2–MgO, and the equiaxed ratio in the solidification structure is 44.63%. However, when Ce content increases to 0.011 wt%, the inclusions in the steel become mainly Ce–S, Ce–O–S, and a small amount of MnS, and the equiaxed ratio increases to 50.42%. As the Ce content increases to 0.017 wt%, the inclusions are predominantly Ce–S, Ce–O–S, and Ce–O–S–Ca, while some Ce–P and Ce–O–P–C inclusions are also observed. The equiaxed ratio increases to 67.63%, showing the best effect on heterogeneous nucleation during solidification. When Ce content in the steel reaches 0.075 wt%, the Ce-containing inclusions are Ce–S, Ce–O, Ce–P, Ce–P–O, and Ce–O–S–As, and the size becomes larger. The formation mechanism of inclusions is explained by Gibbs free energy calculations and thermodynamic diagrams.
The Effects of Phosphate Compounds on the Microstructure and Mechanical Properties of Fly Ash Geopolymer Mortars
Authors: Prochon Piotr , Piotrowski Tomasz , Kępniak Maja
Published: November 2024

Coal-fired power plants are a main source of energy in Poland. In the rapidly growing demand for the reduction of CO2 emission in the energy industry, the use of biomass for energy purposes has increased significantly. The combustion of biomass results in the generation of fly ash, with higher levels of CaO, K2O, P2O5, in contrast to the fly ash derived from the combustion of coal. The aim of this study was to examine the influence of phosphate compounds on fly ash-based geopolymer mortars. Geopolymers were made by mixing two types of fly ash—one from the combustion of wood biomass and the second from the combustion of coal in a heat and power station. Basic activators (NaOH and Na2SiO3) were used for the alkali activation. The maximum level of tetraphosphorus decaoxide addition was established at 5% of the total mass of the aluminosilicate precursors mass. The results showed that the phosphate oxide concentration within the specimens demonstrated a positive correlation with flexural and compressive strength across all temporal intervals (7, 28, and 56 days). The porosity, however, for samples with a 5% addition of P4O10, increased more than twofold in comparison to reference samples (from 4.26% to 9.98%).
Effect of Ag, Sn, and SiCN Surface Coating Layers on the Reliability of Nanotwinned Cu Redistribution Lines Under Temperature Cycling Tests
Authors: Hung Yu-Wen , La Mai-Phuong , Lin Yi-Quan , Chen Chih
Published: November 2024

Nanotwinned Cu (NT-Cu) is a promising candidate for Cu redistribution lines (RDLs). However, oxidation in NT-Cu lines is of concern because it increases electrical resistance and endangers the reliabilities of semiconductor devices such as temperature cycling tests (TCTs). In order to enhance the reliabilities, the passivation of NT-Cu lines is needed. In this study, immersion Ag/Sn and plasma-enhanced chemical vapor deposition (PECVD) SiCN were used to passivate the surfaces of NT-Cu RDLs at low operating temperatures (60 °C for immersion and 150 °C for PECVD). We found that Ag- and SiCN-capped NT-Cu lines showed negligible changes in microstructures and resistance after TCTs. As for Sn-coated NT-Cu lines, the resistance remained stable after 250 cycles of TCTs, with low oxygen signals detected. These three coating layers can block oxygen and moisture, effectively preventing oxidation and maintaining the resistance of NT-Cu RDLs during the TCT. The findings demonstrate the effectiveness of Ag, Sn, and SiCN coatings in enhancing reliability, providing options for passivation layers of NT-Cu RDLs.
Evolution of Properties of High-Strength and High-Mg-Content CuMg Alloys After Being Subjected to Single Operation 50% Deformation in Hot and Cold Upsetting Tests
Authors: Strzępek Paweł , Zasadzińska Małgorzata , Noga Piotr , Skrzekut Tomasz
Published: November 2024

Since most hot and cold metal-forming processes originate from various casting processes, it is important to test their susceptibility to the deformation of new materials. Cast rods of CuMg alloys with a Mg content of 2, 2.4, 2.8, 3, 3.2, 3.6, and 4 wt.% were obtained in the continuous casting process with pure copper as a reference material in order to obtain information on the material’s ability to withstand 50% deformation. The materials in the as-cast state were subjected to solutioning, cold drawing, and recrystallization. After each process, samples were taken and subjected to upsetting tests with 50% deformation applied in a single operation. Additionally, materials in the as-cast state were subjected to upsetting tests at 700 °C. The hardness and electrical conductivity of each sample were analyzed. Selected samples were subjected to microstructural analysis. The obtained results show an increase in hardness from 46 HB to 90–126 HB, and a further increase to 150–190 HB with a quasi-linear decrease of electrical conductivity, which proved the influence of solid-solution and strain hardening, respectively. The microstructural analysis proved that such deformation does not cause microcracks. Furthermore, in the case of CuMg up to 3 wt.% of Mg, the alloying additive completely dissolved after solutioning.
Emerging Trends in Integrated Digital Microfluidic Platforms for Next-Generation Immunoassays
Authors: Su Kaixin , Li Jiaqi , Liu Hailan , Zou Yuan
Published: November 2024

Technologies based on digital microfluidics (DMF) have made significant advancements in the automated manipulation of microscale liquids and complex multistep processes. Due to their numerous benefits, such as automation, speed, cost-effectiveness, and minimal sample volume requirements, these systems are particularly well suited for immunoassays. In this review, an overview is provided of diverse DMF manipulation platforms and their applications in immunological analysis. Initially, droplet-driven DMF platforms based on electrowetting on dielectric (EWOD), magnetic manipulation, surface acoustic wave (SAW), and other related technologies are briefly introduced. The preparation of DMF is then described, including material selection, fabrication techniques and droplet generation. Subsequently, a comprehensive account of advancements in the integration of DMF with various immunoassay techniques is offered, encompassing colorimetric, direct chemiluminescence, enzymatic chemiluminescence, electrosensory, and other immunoassays. Ultimately, the potential challenges and future perspectives in this burgeoning field are delved into.
Ultra-Processed Food Consumption and Its Association with Risk of Obesity, Sedentary Behaviors, and Well-Being in Adolescents
Authors: Machado-Rodrigues Aristides M. , Padez Cristina , Rodrigues Daniela , Dos Santos Elizabete A. , Baptista Liliana C. , Liz Martins Margarida , Fernandes Helder Miguel
Published: November 2024

Background/Objectives: The literature on consumption of ultra-processed food (UPF) using the NOVA classification is still limited. Therefore, the aim of the present study was twofold: (i) to compare the UPF consumption, sedentary behaviors, and well-being perception between boys and girls; and (ii) to investigate the association between the UPF consumption and risk of overweight, sedentary behaviors, and well-being in adolescents. Methods: The present cross-sectional study comprised a sample of 245 adolescents (131 boys) aged 12–17 years-old (M = 14.20; SD = 1.09). Height and weight were assessed, and subsequently, the BMI was computed; furthermore, total body fat percentage was measured with bioelectrical impedance. Daily consumption of UPF was assessed by the NOVA screener and time spent sedentary was assessed by the Midlands Behavior Health 2024 questionnaire. The Mental Health Continuum-Short Form (MHC-SF) was used to measure adolescents’ psychosocial well-being. Pearson’s correlations and logistic regression analysis were used, controlling for biological, behavioral, and socio-economic confounders. Results: No sex differences were observed for the different UPF NOVA subscales. Boys reported higher computer use levels than girls on the weekend (p = 0.025), and they spent more time playing electronic games during the week (p = 0.005) and on the weekend than their female counterparts (p < 0.001). Moreover, boys reported higher scores in all well-being dimensions (p < 0.001) than girls. Conclusions: The findings revealed, after controlling for sex, sedentary time, and active behaviors, adolescents who consumed UPF on the previous day tended to be associated with a higher risk of being overweight, but also marginally without statistical significance (OR = 0.91, 95% CI: 0.83–1.01, p = 0.06). Of relevance, the present study revealed that both boys and girls of mothers with high educational levels were less likely to be classified as overweight or obese youth.