bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhancing Sidechain Rotamer Sampling Using Non-Equilibrium Candidate Monte Carlo
Authors: Burley Kalistyn H. , Gill Samuel C. , Lim Nathan M. , Mobley David
Published: October 2018

Molecular simulations are a valuable tool for studying biomolecular motions and thermodynamics. However, such motions can be slow compared to simulation timescales, yet critical. Specifically, adequate sampling of sidechain motions in protein binding pockets proves crucial for obtaining accurate estimates of ligand binding free energies from molecular simulations. The timescale of sidechain rotamer flips can range from a few ps to several hundred ns or longer, particularly in crowded environments like the interior of proteins. Here, we apply a mixed non-equilibrium candidate Monte Carlo (NCMC)/molecular dynamics (MD) method to enhance sampling of sidechain rotamers. The NCMC portion of our method applies a switching protocol wherein the steric and electrostatic interactions between target sidechain atoms and the surrounding environment are cycled off and then back on during the course of a move proposal. Between NCMC move proposals, simulation of the system continues via traditional molecular dynamics. Here, we first validate this approach on a simple, solvated valine-alanine dipeptide system and then apply it to a well-studied model ligand binding site in T4 lysozyme L99A. We compute the rate of rotamer transitions for a valine sidechain using our approach and compare it to that of traditional molecular dynamics simulations. Here, we show that our NCMC/MD method substantially enhances sidechain sampling, especially in systems where the torsional barrier to rotation is high (>10 kcal/mol). These barriers can be intrinsic torsional barriers or steric barriers imposed by the environment.Overall, this may provide a promising strategy to selectively improve sidechain sampling in molecular simulations.
Decreased The Risk of Hyperbilirubinemia Incidence With The Initiation of Early Breastfeeding
Authors: Yanto Arief , Rochayati Rochayati , Wuryanto Edy
Published: October 2018

Hyperbilirubinemia is a state where increase value of in serum bilirubin in the blood more > 5mg/dl, which is clinically characterized by jaundice on sclera and skin, hyperbilirubinemia can be caused by physiological processes, non-physiological, or a combination of both. Neonates were given early initiation will result in the expenditure of meconium early so tend to have a low risk of the occurrence of physiological hyperbilirubinemia. Research will aim to detect early initiation on the incidence of neonates physiologic hyperbilirubinemia in neonates born at Khadijah room Islamic Hospital Muhammadiyah Kendal. Research kind quasi-experiment by using plant form post test only in a body (one group post test only design). Population in this research patient newborn at Khadijah room Islamic Hospital Muhammadiyah Kendal. Research sample as much as 30  respondens early initiation and 30 respondens not early initiation by using technique purposive sampling. Data analysis included univariate analysis by finding frequency distribution, bivariate analysis with Mann-Whitney Test. The research result of bivariate analysis shows that neonates with early initiation total serum bilirubin value performed intervention group averaged 8,200mg/dl while control group averaged 11,647mg /dl. The initiation of early breastfeeding (IMD) effect on total serum billirubin content of the neonatus. The variables that have contributed to the total serum billirubin content were the implementation of early breastfeeding initiation (IMD) with an effect of 61.2% and influenced by other variables of 38.8%. The conclusion there is influence of early initiation of suckling on physiological hyprbilirubinemia at Islamic Hospital Muhammadiyah Kendal.
ФУНДАМЕНТАЛЬНЫЕ ВОПРОСЫ ЭФФЕКТИВНОГО ПРЕДПРИНИМАТЕЛЬСТВА: НАУЧНЫЙ ПОИСК И НОВЫЕ РЕШЕНИЯ
Authors: Казиханов Адильхан Магомедтагирович
Published: October 2018

Предмет и цель работы. Предмет исследования – поиск новых решений в повышении эффективности предпринимательства в рамках инновационно-стимулирующего режима работы адекватным условиям трудоизбыточных регионов.  Цель работы – обоснование необходимости ускоренного перехода на новую модель экономики в аграрном секторе экономики, направленного на снижение дотационности региона. Методология проведения работы. Обоснована актуальность развития крупного предпринимательства в трудоизбыточных регионах как гарант достижения социальной стабильности. В результате анализа обозначены наиболее важные проблемы, от решения которых зависит эффективность предпринимательства. Это: кредит, налоги, занятость, повышение роли государства, конкурентоспособность. Результаты работы. Разработаны предложения по повышению эффективности крупного предпринимательства и созданию предпосылок к переходу на цифровую экономику. Обозначены первоочередные задачи, решение которых ускорит достижения постановленной цели. Область применения результатов. Результаты исследования могут быть использованы органами власти при разработке нормативно-правовой базы перехода к цифровой экономике, и выработке опережающих мер на новые вызовы. Выводы. Ускоренный переход к цифровой экономике – это веление времени. Необходимо приступить к созданию инфраструктуры цифровой экономики, новых научных центров, площадок и ускорить начавшийся процесс конвергенции.
ИНТЕГРАЦИОННАЯ МОДЕЛЬ РАЗВИТИЯ ПИЩЕВОЙ И ПЕРЕРАБАТЫВАЮЩЕЙ ПРОМЫШЛЕННОСТИ РД
Authors: Абдуллаева Тамара Курбановна , Муммуев Магомед Рамазанович , Алиева Алина Алиевна
Published: October 2018

Цель работы. Целью работы является определение перспективных направлений развития пищевой и перерабатывающей промышленности региона на основе построения интеграционных связей. Метод или методология проведения работы. Исследование основывается на общенаучной методологии и предусматривает применение системного подхода к решению поставленных задач. В основе исследования лежат фундаментальные труды отечественных и зарубежных ученых по проблемам управления развитием пищевых и перерабатывающих промышленных производств АПК РД. Результаты. Важнейшим фактором стабилизации экономики и основным условием активизации деятельности предприятий пищевой промышленности является развитие интеграционных связей, которые служат главным звеном конкурентоспособности. Развитие интеграционных связей служит ключевым компонентом конкурентоспособности, и в конечном итоге перерабатывающая промышленность должна развиваться по интеграционной модели, образовывая отраслевые компании, холдинги, кооперативы, союзы, занимающиеся производством, переработкой и реализацией. Интеграционная модель развития пищевой промышленности позволит сформировать и развивать взаимовыгодные отношения производителей сырья, переработчиков и продавцов продукции; наладить систему закупок сырья у сельхозтоваропроизводителей по ценам, обеспечивающим их расширенное воспроизводство; получать авансирование под весенне-полевые и уборочные работы; улучшить регулирование экономических отношений между сельхозтоваропроизводителями и сферой их обслуживания; получить выходы на рынки других регионов, производить продукцию, способную конкурировать с аналогами. В современных экономических условиях одним из приоритетных направлений развития пищевой промышленности является построение интеграционных связей. Область применения результатов. Результаты проведенного исследования могут использоваться органами управления АПК при проведении реструктуризации отраслей пищевой промышленности в целях эффективного управления развитием регионального АПК. Выводы. С целью создания благоприятных условий развития пищевой и перерабатывающей промышленности региона, а также в целом экономики Республики Дагестан крайне выгодным становится создание интегрированных структур, в которые будут входить все участники процесса производства пищевой продукции – начиная с поставки сырья до его переработки, с осуществлением пищевыми и перерабатывающими предприятиями целевого финансирования производства.
ОСОБЕННОСТИ ИННОВАЦИОННО ОРИЕНТИРОВАННЫХ СТАРТАПОВ В КОНТЕКСТЕ ДЛИННОВОЛНОВОЙ ДИНАМИКИ
Authors: Акинфеева Екатерина Владимировна , Ерзнкян Баграт Айкович
Published: October 2018

Предметом исследования являются ориентированные на инновации стартапы как элементы технологических и институциональных укладов. Цель исследования: выявление особенностей инновационно ориентированных стартапов с позиций их соответствия логике длинноволновой динамики социально-экономического развития. Метод или методология: использованы аналитические методы сбора и обработки информации, базирующиеся методологически на теории длинных волн и институциональной экономики. Результаты работы: 1. Показано, что эффективность деятельности инновационно ориентированных стартапов следует оценивать по их способности активизировать становление и развитие нового технологического уклада в рамках логики длинноволновой динамики. 2. Приведены причины технологического отставания России, выявленные путем сопоставления основных характеристик мировых и отечественных стартапов, а также характеристик всех шести технологических укладов. Область применения результатов: они могут быть использованы органами государственного регулирования при разработке и реализации инновационной политики, а также всеми заинтересованными структурами, имеющими отношение к созданию и функционированию инновационных стартапов. Выводы: 1. Успешность технологического развития предопределяется его соответствующим институциональным обеспечением. 2. В настоящее время в России доминирующее место занимают стартапы в сфере информационных технологий.
ВЛИЯНИЕ МИГРАЦИИ НА ДЕМОГРАФИЧЕСКОЕ РАЗВИТИЕ СКФО И ПОДХОДЫ К ЕЕ РЕГУЛИРОВАНИЮ В СОВРЕМЕННЫХ УСЛОВИЯХ
Authors: Абдулманапов Пирмагомед Габибуллаевич
Published: October 2018

Цель исследования. Определение вклада миграции в демографическое развитие регионов в Северо-Кавказском федеральном округе России и разработка направлений по совершенствованию миграционной политики на основе анализа миграционных процессов и трансформации демографических процессов. Метод. Поставленные в исследовании задачи определили необходимость использования комплекса методов, в том числе абстрактно-логического, монографического, экспериментального, расчетно-конструктивно-го, метода сравнительного анализа, эконометрического моделирования. Результаты. Выявлена трансформация социально-демографических параметров, детерминированная усилением миграционных процессов. Происходящие в СКФО миграционные процессы оказывают воздействие на последующее развитие этносоциальной и демографической ситуации. К настоящему времени миграционные процессы существенно изменили демографическую структуру населения как в регионах-реципиентах, увеличив долю населения молодых возрастов из национальных республик с относительно высокими репродуктивными установками, так и в регионах-донорах, снизив, наоборот, репродуктивный потенциал за счет уменьшения численности населения молодых возрастов. В результате снизилась доля русскоязычного населения в регионе, исторически заселенного русским этносом – в Ставропольском крае – и увеличилась доля кавказских этносов, но в то же время из-за подобных трансформаций в половозрастном и этносоциальном составе сложился положительный естественный прирост. С учетом данных последствий разработаны рекомендации по совершенствованию регулирования как внутрирегиональной миграции, так и межрегиональной в интересах социально-экономического и демографического развития субъектов округа. Область применения результатов. Результаты проведенного исследования могут быть использованы органами исполнительной власти региона при разработке мер социально-демографического развития регионов Северного Кавказа, при формировании программ поддержки мигрантов и их адаптации на новом месте проживания. Выводы. Делается вывод о том, что при формировании государственной политики в области народонаселения необходимо учитывать миграционный компонент воспроизводства населения как фактора изменения не только количественных демографических характеристик, но и качественных (возрастно-половая структура).
The correlation between electronic structure and antitumor activity of a seletive focal adhesion kinase inhibitors
Authors: Barra de Oliveira Daniel Augusto
Published: October 2018

Focal Adhesion Kinase (FAK) is a non-tyrosine kinase responsible to phosphorylate other enzymes associated with signal transduction. This biochemical process plays an important role to control cancer. FAK is found overexpressed in the organism during metastasis. Since FAK may be involved in the invasion and metastasis of cancer, novel molecules based on drug design have been synthesized over the past few years. The inhibitors are designed to mimic the natural substrate which is the ATP molecule. This work studied the hydrogen bonds performed between inhibitors and FAK and other electronic properties involved in this interaction. The molecular structure of FAK docked with the inhibitors was simulated using classical molecular dynamics. FAK/ inhibitor complex obtained by dynamic was optimized using quantum mechanical ab-initio calculation. Our results show that all inhibitors interact with Cys502 located in the FAK-binding site. Ab-initio calculations show that HOMO orbital is situated under Met499 and Glu500 amino acids indicating chemical reactivity in this region. The results of molecular dynamics combined with quantum chemical calculations show that the sulfonamide has a strong hydrogen bond with close distances, while the thiazole has a weak hydrogen bond with long distances. Sulfonamide has known good activity against FAK while the thiazole molecule has an unknown activity. These results allow predicting that the molecule of thiazole is a not good inhibitor to FAK inhibition.
Yerleşik Bazı Siyer Rivayetlerinin Kuran-ı Kerim'e Arzı
Authors: SEVERCAN Şefaettin
Published: October 2018

Hz. Muhammed (s.)’in vahye ilk muhatap olmasıyla
birlikte peygamber olduğu bilinci ve peygamberliğinin ilk üç yılında gizliliği
ile ilgili yerleşik siyer rivayetleri ile Kur’ân-ı Kerim’in ilk inen ayetlerinin
beyanları arasındaki farklılıklar, çok açık ve nettir. Burada bize düşen, yukarıda
makale sınırlılığında naklettiğimiz şekilde, hiç tereddüt etmeden Kur’ânî
beyanları siyer nakillerinin önüne geçirmektir.
Occurrence of the exotic shell-bearing Bulla ampulla, Linnaeus, 1758 (Mollusca, Gastropoda) in the Gulf of Antalya
Authors: GÖKOGLU Mehmet , TEKER Serkan , KORUN Jale
Published: October 2018

Bulla ampulla, belonging to Bullidae family, is a marine gastropod species with bulb. Members of Bullidae family are distributed in tropical and temperate waters. It is usually found in habitats of sand, mud, gravel, gren algae and sea bottoms, at intertidal flats, on tide-pond sand at depths of up to 70 m. For another scientific study conducted at Konyaaltı beach (36.883522° N, 30.678739° E), while doing scuba diving at a depth of 15 m; Pinctada radiata, Venus verricosa, Chama pacifica shells and two Bulla ampulla shells were found near the octopus nest. Shell of our species was measured as H:53,61 and 46,23mm, color; Brown greenish with two dark bands and shell elongate. The biodiversity of the exotic species of the Gulf of Antalya has slightly increased with the presence of this species.
Seasonal Variation in the Length-Weight Relationships and Condition Factor of Four Commercially Important Sea Cucumbers Species from Karachi Coast- Northern Arabian Sea
Authors: AHMED Quratulan , POOT-SALAZAR Alicia , MOHAMMAD ALİ Qadeer , BAT Levent
Published: October 2018

Length-weight relationships and condition assessment are a common practice in fisheries analyses; however, such information is unknown for most sea cucumber species. The present study investigated length-weight relationships and relative condition indices of four commercially important sea cucumbers: Holothuria arenicola, Holothuria atra, Holothuria pardalis and Holothuria verrucosa. Additionally, the seasonal variations obtained between three climatic seasons (pre-monsoon, monsoon and post-monsoon) were analyzed. The results showed that the four species grow allometrically, with negative allometric b values ranging from 0.84 to 1.74. There were significant differences of length-weight relationships between climatic seasons for H. arenicola and H. atra. The lower b values were observed during post-monsoon and the higher b values during monsoon in three of the four species. During the post-monsoon, the condition of the bigger individuals of H. arenicola and H. atra was lower than that of the small individuals. The differences in length-weight relationships of H. pardalis and H. verrucosa were not significant between climatic events. The higher temperatures occurred during monsoon and the lower during post-monsoon, but these data only showed a significant correlation with the relative condition factor of H. arenicola. Best condition of the individuals of H. arenicola occurred at temperatures between 22 to 31°C. Studies about environmental variables and characteristics of the substratum type are necessary in order to complement the understanding of the length-weight relationships and condition of these species.
Characterization and Construction of a Robust and Elastic Wall-Less Flow Phantom for High Pressure Flow Rate Using Doppler Ultrasound Applications
Authors: AMMAR A. Oglat , MATJAFRİ Mz , SUARDİ Nursakinah , OQLAT Mohammad A. , OQLAT Ahmad A. , ABDELRAHMAN Mostafa A , FARHAT O.f. , AHMAD Muntaser S. , ALKHATEB Batool N. , GEMANAM Sylvester J. , SHALBİ Sabri M. , ABDALRHEEM Raed , SHİPLİ Marwan , MARASHDEH Mohammad
Published: October 2018

A Doppler ultrasound is a noninvasive test that can be used to estimate the blood flow through the vessels. Presently, few flow phantoms are being used to be qualified for long-term utilize and storage with high physiological flow rate Doppler ultrasound. The main drawback of the two hydrogel materials items (Konjac (K) and carrageenan (C) (KC)) that it is not fit for long-term storage and easy to deteriorate. Thus, this research study focuses on the characterization and construction of a robust and elastic wall-less flow phantom with suitable acoustical properties of TMM. The mechanisms for the fabrication of a wall-less flow phantom utilizing a physically strong material such as K, C, and gelatin (bovine skin)-based TMM were explained. In addition, the clinical ultrasound (Hitachi Avius (HI)) system was used as the main instrument for data acquisition. Vessel mimicking material (VMM) with dimensions of 15.0 mm depth equal to those of human common carotid arteries (CCA) were obtained with pulsatile flow. The acoustical properties (speed of sound and attenuation were 1533±2 m/s and 0.2 dB/cm. MHz, respectively) of a new TMM were agreed with the IEC 61685 standards. Furthermore, the velocity percentages error were decreased with increase in the Doppler angle (the lowest % error (3%) it was at 53◦). The gelatin from bovine skin was a proper material to be added to KC to enhance the strength of TMM during for long-term utilize and storage of high-flow of blood mimicking Fluid (BMF). This wall-less flow phantom will be a suitable instrument for examining in-vitro research studies.
Solution of Traveler’s Dilemma
Authors: OSIECKA Gabriela , JASIŃSKI Maciej
Published: October 2018

Aim: The aim of the article is to show: 1) that the reasoning of perfectly rational players presented in 1994 by the author of the Traveler's Dilemma Kaushik Basu is incorrect and therefore leads to wrong conclusions, 2) how the reasoning of these players should look like and what solution it leads to. Design / Research methods: Logical analysis. Conclusions / findings: Perfectly rational Traveler’s Dilemma players should use, according to game theory, so-called retrograde (iterative) induction. This is wrong, as in the set of Traveler’s Dilemma games results the principle of transitivity is not met. We believe that perfectly rational players will achieve a better result when they make a random decision from a suitably limited set of decisions. After applying this method of decision making, perfectly rational players will achieve a result similar to those obtained by real players in experiments. Thus, the paradox described in the theory of games disappears, that perfectly rational players achieve worse results than real players Originality / value of the article: A new way of making decisions in the Traveler’s Dilemma game. Implications of the research: A new way of making decisions in other games similar to the Traveler’s Dilemma may allow to find new solutions in these games. Limitations of the research: The described decision-making method can potentially be used in decision-making situations when the following five conditions are met: 1) the set of possible decisions of each player is greater than 2, 2) the winning matrix is known to both players and both know the purpose of their choices, 3) when it is played once with an unknown opponent, 4) when both players have to make their decision without knowing the opponent's choice, 5) when there is no decision, which is a stable balance point or when it is, but its choice means that the player does not achieve a satisfying result.
Measuring Productivity and Efficiency of Seaports in India using DEA technique
Authors: MONTEIRO Jeronimo Guilherme Remigio
Published: October 2018

Aim: In this paper we are looking at the seaports (in India called ‘major ports’) from the context of its trade and India’s strategic importance in trade world after the initiation of economic reforms in 1991. It empirically estimates the levels of productivity and efficiency of seaports in India. This paper applies DEA technique to assess productivity and efficiency of seaports in India. Design/Research methods: DEA technique is extensively used in the literature of economics to provide measures of firms’ technical efficiency. These measures rank the firms by looking at their apparent performances over a period of time. DEA is a frontier model which is non-parametric since no functional specification or form is required to be mentioned. Conclusions/Findings: The DEA results as discussed and reported in the paper have shown how Indian ports are performing over the years. This investigation alone is not sufficient to develop a benchmark in the port system of India. Rather it will do well to have a closer look at the Indian ports from the physical and financial performance point of view. This study made use of data envelopment analysis (DEA) to generate what we call an efficiency benchmarks and assessment of the Indian ports sector. With this modest attempt to investigate the port sector of India several issues are in the open one can further analyze and come to desired conclusions. Originality/value of the paper: The main role of a port is to transfer goods between two transport modes. As far as Indian ports are concerned, there are few studies with regard to productivity and efficiency of the port sector. Since, there is an attempt in recent years to overhaul the infrastructure sectors of the Indian economy and especially seaports. There is a need to look at issues in port sector as well. Productivity and efficiency concerns should be the main aspect of the benchmarking of the performance of today’s Indian ports. Limitations of the research: Second stage DEA, distance function approach, Bayesian techniques, Carlo Monte techniques, can be alternatively used.
Nonexistence Proofs for Five Ternary Linear Codes
Authors: GURITMAN S.
Published: October 2018

An [n,k, dh-code is a ternary linear code with length n, dimension k and minimum distance d. We prove that codes with parameters [110,6, 72h, [109,6,71h, [237,6,157b, [69,7,43h, and [120,9,75h do not exist.
Penetapan Tarif Optimal dengan Model Permainan Stackelberg
Authors: LESMANA D. C. , PRIYARSONO D. S. , HANUM F.
Published: October 2018

Tarif dapat digunakan untuk mencegah industri asing melakukan praktik- praktik untuk menarik keuntungan atas industri domestik yang menyebabkan penurunan pendapatan nasional. Jika pasar suatu negara adalah oligopolistik maka ada dua akibat tarnbahan dari penurunan tarif yang cenderung mengu- rangi kesejahteraan negara. Pertarna, jika produsen asing mempunyai keku- atan pasar, maka negara pengimpor mernbayar dengan harga yan.g lebih tinggi daripada biaya marjinal. Derrgan mernberlakukan tarif, negara dapat rnerrgam- bil sebagian surplus monopolis. Kedua, proteksi monopolis domestik meng- hasilkan keuntungan. Sebagian keuntungan ini akan mengalir ke perusahaan asing setelah penurunan tarif. Hal ini mengakibatkan penurunan kesejahte- raan negara.
DISCRIMINANT FUNCTIONS AND THEIR MISCLASSIFICATION ERRORS
Authors: MANGKU I W.
Published: October 2018

This paper is a survey study on discriminant functions and their misclassiﬁcation errors. Here we consider three groups of discriminant functions, namely discriminant functions for respec- tively multivariate normal variables, multivariate binary variables, and a mixture of multivariate binary and normal variables. Finally we derive their misclassiﬁcation errors.
SUATU FORMULASI LAGRANGE BAGI GERAK GELOMBANG INTERNAL
Authors: JAHARUDDIN J.
Published: October 2018

Dalam tulisan ini diturunkan persamaan gerak gelom- bang internal di laut dengan menggunakan suatu formulasi La- grange. Persamaan yang diperoleh berupa persamaan Korteweg- de Vries (KdV) untuk perairan yang dangkal. Selain itu diper- oleh pula persamaan Benjamin-Ono (BO)untuk laut yang memiliki kedalaman yang sangat besar.
MODELLING AND DESIGN OF ROBUST CONTROL FOR PASSANGER CAR SUSPENSION SYSTEM
Authors: KUSNANTO A.
Published: October 2018

There are many uncertainties that occur in characterizing systems and environment in which they have to operate. Due to the uncertainties, no classical control theories are applicable to systems properly. Because of that, new theories occur for solving the problem. One of the new theory is H∞ theory. In this paper, it is given the application of H∞ theory in design of controller. The controller will be applied to damp out the vibration of passanger car. In this works, the roughness of road is modelled as uncertainties.
SOLUSI NUMERIK PERSAMAAN BOLTZMANN
Authors: NUGRAHANI E. H.
Published: October 2018

Particle methods are well known tools to solve the kinetic Boltzmann equation numerically. The usual procedure of such method is the direct simulation Monte-Carlo, which directly simulate the collision between particles. The second method of interest is the stochastic weighted particle method, which is developed to improve the previous method. The main idea of the second method is to use random weight transfer between particles during collisions. In order to reduce the stochastic fluctuations, this method provides a way to increase the number of particles. But if the additional particles cannot be compensated in some natural way, then this number should be reduced. Several reduction procedures have been proposed. Some numerical results using both methods are presented. It is shown that the second method gives some better results in some ways.
BENTUK FUNGSIONAL TINGKAT FERTILITAS ALAMI DAN TINGKAT PERILAKU HENTIAN
Authors: SUMARNO H.
Published: October 2018

Tingkat fertilitas perkawinan umur a menyatakan intensitas kelahiran bagi wanita umur a, jika ia menikah mulai dari awal masa reproduksinya. Dalam model Coale-Trussell, tingkat fertilitas perkawinan umur a dapat diuraikan menjadi dua komponen, yakni tingkat fertilitas alami standar umur a, n(a), dan tingkat perilaku hentian standar umur a, v(a).  Tujuan kajian ini ialah membuat kedua komponen n(a) dan v(a) menjadi bentuk fungsional. Proses ini akan mentransformasi model Coale- Trussell menjadi kurva kontinu. Dengan menggunakan model kontinu, diharapkan akan dapat meningkatkan kemampuan model menyuai data, terutama dalam analisis data skala mikro, karena variasi intensitas kelahiran menurut umur dapat dimodelkan dengan lebih cermat.
AN OPTIMAL TRANSACTION INTERVALS FOR PORTFOLIO SELECTION PROBLEM WITH BULLET TRANSACTION COS
Authors: SYAHRIL E.
Published: October 2018

This paper discusses an optimal transaction interval for a consumption and investment decision problem for an indi- vidual who has available a riskless asset paying ﬁxed interest rate and a risky asset driven by Brownian motion price ﬂuctuations. The individual observes current wealth when making transactions, that transactions incur costs, and that decisions to transact can be made at any time based on all current information. The trans- actions costs is ﬁxed for every transaction, regardless of amount transacted. In addition, the investor is charged a ﬁxed fraction of total wealth as management fee. The investor’s objective is to maximize the expected utility of consumption over a given horizon. The problem faced by the investor is formulated in a stochastic discrete-continuous-time control problem. An optimal transaction interval for the inverstor is derived.
SUATU FORMULASI HAMILTON BAGI GERAK GELOMBANG INTERFACIAL YANG MERAMBAT DALAM DUA ARAH
Authors: JAHARUDDIN J.
Published: October 2018

Dalam artikel ini dibahas suatu formulasi Hamilton untuk menggambarkan gerak gelombang interfacial yang meram- bat dalam dua arah. Persamaan Boussinesq yang diperoleh ditun- jukkan memiliki struktur sebagai suatu sistem Hamilton dengan peubah kanoniknya adalah simpangan gelombang di interface yang bergerak ke arah kanan, dan simpangan gelombang lainnya yang bergerak ke arah kiri. Dalam hal ini menggunakan asumsi batas atas rata. Hamilton dari sistem ini adalah penjumlahan energi kinetik dan energi potensialnya, tetapi berdasarkan pada asumsi gelombang panjang dan amplitudo kecil.
PENGGUNAAN ALGORITMA COLUMN GENERATION UNTUK MENENTUKAN RUTE OPTIMAL PENGANGKUTAN SAMPAH DI KOTA BOGOR
Authors: HANUM F.
Published: October 2018

Pengelolaan sampah di kota-kota besar pada saat ini telah menimbulkan persoalan lingkungan yang memerlukan penanganan segera. Jika tidak dikelola dengan baik, maka sampah akan menjadi sumber penyakit, menimbulkan bau busuk, mencemari air tanah, menimbulkan banjir, dan mengurangi keindahan lingkungan. Ada beberapa tahapan pengelolaan sampah yang selama ini dilakukan di beberapa kota di Indonesia yaitu (i) mengumpulkan sampah dari lokasi penghasil sampah (sumber sampah) kemudian diangkut ke TPS (Tempat Penampungan Sementara) sampah, (ii) mengangkut sampah dari TPS-TPS ke TPA (Tempat Pembuangan Akhir) sampah, dan (iii) memusnahkan sampah dengan lahan urug saniter, membakarnya di dalam incenerator, atau mengelola sampah menjadi barang yang dapat dipakai lagi, misalkan kompos, barang-barang keperluan rumah tangga dll. Di kota Bogor, biaya pengangkutan sampah ternyata lebih tinggi dibandingkan dengan biaya komponen lain dalam pengelolaan sampah. Pada penelitian ini, dilakukan pemodelan pengangkutan sampah di kota Bogor dengan capacitated node routing problem dan penentuan solusi optimalnya dengan menggunakan algoritma column generation.
MODEL OPTIMAL SISTEM TRANSPORTASI ANGKUTAN KOTA
Authors: SUPRIYO P. T.
Published: October 2018

Sistem transportasi perkotaan yang optimal sangat bergantung dengan upaya menyelesaikan masalah penjadwalan armada angkutan kotanya.  Hal ini memiliki beberapa masalah khusus.  Salah satu masalah tersebut adalah pengaturan perhentian untuk rute bercabang sedemikian sehingga memberikan kelancaran operasi penggabungan dengan jumlah armada minimum.  Masalah penentuan perhentian sedemikian sehingga meminimumkan jumlah armada untuk pengoperasian rute bercabang diperlihatkan analog dengan masalah inventori atau antrian deterministik sederhana.  Jumlah armada minimum yang diperlukan untuk mengoperasikan rute semacam ini diperlihatkan sama dengan daur kendaraan rataan dibagi dengan headway utama.
ASYMPTOTIC NORMALITY OF A KERNEL-TYPE ESTIMATOR FOR THE INTENSITY OF A PERIODIC POISSON PROCESS
Authors: MANGKU I W.
Published: October 2018

In this paper we prove asymptotic normality of a kernel type estimator for the intensity of a periodic Poisson process. This paper is a continuation of [10]. As in [10], we consider the situation when the period is known in order to be able to present simple proofs of the results.1991 Mathematics Subject Classiﬁcation: 60G55, 62G05, 62G20.
Nuestros colaboradores
Authors: Colaboradores Nuestros
Published: October 2018

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An Evaluative Head in Romance
Authors: Giorgi Alessandra , Sorrisi Fabrizio
Published: October 2018

In this work, we analyse the behaviour of a verbal suffix in Palermitan – the Romance language spoken in Palermo, Sicily – expressing an evaluative meaning with sentential scope. The suffix is (V)vu, where V is the thematic vowel of the verb. The Palermitan dialect we study here is the one spoken in the urban area, approximately by 250,000 speakers. This suffix is interesting for several reasons. In the first place, an evaluative morpheme with clausal scope is quite unusual in Romance and to our knowledge it has not been reported outside Sicily. In the second place, as we will illustrate later, its use is spreading among the youngest generation, showing that the dialect is productive and the form under scrutiny is adopted by larger segments of the population, even if it does not exist in Italian.
As ‘vidas’ de Jorge de Lima
Authors: D'Avila de Oliveira Leonardo
Published: October 2018

The Brazilian poet Jorge Lima, better known for his relation with surrealist aesthetics and popular culture, wrote several lives of saints that depart from the Brazilian modernist context. Although Catholicism is sometimes manifest in his poetic works, these ‘lives’ constitute a point of antagonism for their informative prose and for their selective restrictions on images. By their supposed imitation of divinity and their abandonment of the self, the texts Anchieta, Dom Vital and A vida extraordinária de Santo Antônioare related both to the Spanish mysticism of San Juan de la Cruz, and to the Christian rhetoric of the sermo humilis as deployed by Jesuit colonial authors. The article aims to investigate some parallels between previous hagiographies and Lima’s texts as well as to demonstrate how these modernist ‘lives’ inevitably fail in their attempt to manifest their humble vocabulary and imagery, performing a paradoxical auto-hagiography.
Features Extraction for Pollen Recognition Using Gabor Filters
Authors: Nikolov Dimitar Nikolov , Tsankova Diana Dimitrova
Published: October 2018

The aim of the article is to investigate the features extraction from microscope images of pollens for a classification of honey on the base of its botanical origin. A filter-bank of Gabor filters (as a biologically inspired recognition system) is used to obtain features, which are then post-processed using normalization, down-sampling (by bicubic interpolation), and principal components analysis (PCA). PCA is used for reducing the features size and a proper visualization of the features extraction results. Microscope images from the European pollen database, including pollen images of linden, acacia, lavender, rapeseed, and thistle, are used to illustrate capabilities of the proposed features extraction approach. The performance of the proposed algorithm is evaluated by simulations in MATLAB environment.
Optimization of technological parameters for osmotic dehydration of black chokeberry
Authors: Aleksandrov Svetoslav Stoyanov , Petrova Todorka , Bakalov Ivan , Ruskova Milena , Popesku Emilian , Hristov Hristo , Gotcheva Velitchka , Penov Nikolay
Published: October 2018

Many plant extracts selected for their high in vitro antibacterial activity in microbiological media have a far lower in situ antibacterial activity in foods. This is likely due to interactions of plant antimicrobial molecules with food components such as proteins or dispersed fat at the expense of their interaction with target unwanted bacteria. Gaillac red wine powder and Cinnamon cassia essential oil were selected for their in vitro antibacterial activity against Staphylococcus aureus CNRZ3 and Listeria innocua LRGIA 01, respectively. In order to assess their potential application to the preservation of raw meat or dairy products, respectively, their antibacterial activity was tested in Mueller Hinton broth (MHB) supplemented with up to 20% beef meat proteins to mimick raw beef meat protein content and in TSB, skimmed, semi-skimmed and whole milk, respectively. Supplementation of MHB with beef extract proteins annihilated the antibacterial activity of Gaillac red wine powder as well as of resveratrol, a stilbene polyphenol present in red wine. The comparison of the anti-Listeria innocua activity of C. cassia essential oil in TSB 1% (w/w), skimmed, semi-skimmed and whole milk led to the conclusion that its antibacterial activity was significantly reduced in the presence of milk fat globules but not significantly by milk proteins. Complexified microbiological media or liquid foods such as sterilized milk with various milk fat contents might thus be valuable tools for the rapid screening of antibacterial plant extracts of interest for perishable foods preservation.
Antifungal properties of SiO2/hydroxypropyl cellulose hybrid materials doped with zinc ions against Candida albicans 74
Authors: Angelova Tzvetelina , Rangelova Nadezhda , Georgieva Nelly
Published: October 2018

This study presents an investigation of antifungal properties of hybrid materials based on silica, hydroxypropyl cellulose and ZnSO4.7H2O. The hybrid materials were synthesized by sol-gel technique and as a source of silica was used tetraethylortho silicate (TEOS). The quantity of organic substance was 5 wt. % and the zinc concentration varied from 0,5 to 5 wt. %. The strain that was used for determination of potential antifungal activity of materials was Candida albicans 74. The first experiment was focused on counting the survived cells after contact of fungi and materials with different zinc concentrations. The results show that the zinc amount and the cultivation time influence the number of colonies. The second method was based on measuring the free zone of fugal growth formed around well with materials. It was examined that the zone size depends on the amount of zinc ions in the materials.
A specificity of microstructural and biochemical changes during ripening of dark, firm and dry sheep meat
Authors: Dragoev Stefan Georgiev , Vlahova-Vangelova Dessislava , Balev Dessislav , Igenbaev Aydun , Kassimov Samat
Published: October 2018

The objective of this study was to recognize the specificity of microstructural changes of DFD sheep m. Longissimus dorsi during its ripening, and to try to explain them by biochemical and physicochemical amendments of meat. The fresh (4 h post mortem) DFD sheep m. Longissimus dorsi with pH1 = 6.95 stored at 2 ± 2°C was used. The microstructure, degree of proteolysis, color properties, water holding capacity and pH of DFD sheep meat were evaluated during 5d of storage. The shortenings of the sarcomeres and typical alternation of light and dark bands were established after 48h storage of DFD sheep muscles. Simultaneously, pH and water holding capacity decreased with 16.5% and 50.6% resp. (p ≤ 0.05), accompanied with the lowest protein solubility, and a disappearance of myosin heavy chains. On the 3d post mortem sarcomeres were partly regenerated and their native structure was recovered, A- and I-disks were visible, and Z-lines were undamaged. On the 4d post mortem was found large gap formation in sarcomeres and difficulty recognizable A- and I-disks. On the 5d post mortem the pH and water holding capacity were similar (p > 0.05) with the initial values but free amino nitrogen decreased with 34.5%.
Measuring Dyed Fiber Color with MSFU-K Microscope Spectrophotometer: Methodology Validation
Authors: Bebeshko Galina I. , Lyubetskaya Irina P. , Brunova Lidiya P. , Khanukaeva Marina A. , Omel'yanyuk Georgii G.
Published: October 2018

This work is part of a series of efforts towards validation of methods used in forensic fiber analysis. These efforts address current needs for accreditation of forensic laboratories and quality control in operations.

The qualitative testing methodology consists of obtaining absorption spectra with the microscope spectrophotometer MSFU-K and comparing the spectral characteristics of color in fiber samples. The expert determines whether the textile fibers submitted for analysis match in color or not, depending on the results of spectral comparison.

The proposed validation experiment algorithm is designed for evaluating uncertainty in optical density measurements and the level of expert competence.

In this case uncertainty corresponds to reproducibility standard deviation. To evaluate uncertainty, two operators took readings of absorption spectra of dyed fibers independently in the course of three days, and measured optical density at maximum and minimum absorption wavelengths. To evaluate repeatability, 5 spectra were obtained in a row on each of the three days.

The testing was conducted using three samples of polyacrylonitrile (PAN) fibers. Key characteristic points in the samples’ absorption spectra covered a wide range of wavelengths in the visible spectrum. Measurements were taken using the MSFU-K microspectrophotometer, which consists of a microscope with a spectrophotometric add-on unit.

Statistical analysis of measurement data demonstrated uncertainty levels between 7,1 % and 22,1 %. Uncertainty values below 30 % are indicative of quantitative measurements and insignificant variance of optical density values, which corresponds to high reproducibility of spectra and allows the expert to make statistically reliable match/non-match conclusions on the color of compared fibers.

Expert competence was assessed based on «blind» test results. The experts had to determine which of the three samples were colored with the same dye. Each of the two experts was provided with 3 visually identical samples that were colored with different dyes. The experts were asked to distinguish between fibers treated with the same dye. When analyzing obtained spectra, both experts correctly identified same-color fibers based on matching color spectral characteristics.

Positive validation results suggest that the MSFU-K microscope spectrophotometer can be successfully used in forensic fiber analysis for measuring the color of dyed fibers.
Klasifikasi Teks Emosi Bahasa Aceh Menggunakan Metode Term Frekuensi / Invers Dokument Frekuensi
Authors: Mursyidah Mursyidah , Hidayat Hari Toha
Published: October 2018

Abstrak-Dalam bahasa Aceh teks emosi marah, senang, sedih, jijik dan normal dapat dinyatakan dalam bentuk verbal (menulis kata- kata). Emosi marah, senang, sedih, jijik dan normal juga dapat ditunjukkan dengan teks, akan tetapi tingkatan emosinya agak sulit ditebak disebabkan teks yang tidak dikenali suatu teks itu berupa emosi marah, senang, sedih, jijik dan bahkan emosi normal. Tingkatan emosinya agak sulit ditebak karena dalam bahasa aceh teks emosi belum tentu dapat digambarkan dengan pasti perasaan emosi yang dirasakan oleh teks itu sendiri. Oleh karena itu, dibuat sebuah program aplikasi yang dapat mengetahui tingkat emosi seseorang. Penelitian ini bertujuan untuk membahas teks emosi marah melalui kalimat atau teks marah, senang, sedih, jijik dan normal dalam bahasa Aceh untuk memperoleh tampilan persentase tingkat emosi dari suatu teks. Program aplikasi ini menggunakan metode Term Frekuensi / Invers Dokument Frekuensi. Penelitian sistem aplikasi ini menghasilkan akurasi kebenaran prediksi sebesar 80%. Kata Kunci : Teks Emosi, TF-IDF , Klasifikasi teks
Penerapan Metode AHP(Analythyc Hierarchy Proses) Untuk Membuka Warung Kopi
Authors: Mahdi Mahdi
Published: October 2018

Lokasi warung   kopi  sangat menetukan jumlah pengunjung, hal ini disebabkan jika lokasi warungkopi letaknya sangat strategis maka akan banyak pengunjungnya setiap hari. Warung kopi bagi masyarakat Aceh merupakan tempat dimana masyarakat berkumpul untuk sekedar melepas lelah atupun tempat mengawali hari sebelum melaksanakan aktivitas rutin. Seiring pertumbuhan penduduk yang semakin pesat maka kebutuhan warung kopi juga akan semakin banyak. Hal ini akan membuka peluang bisnis yang menjajikan dengan usaha warung kopi. Namum dalam memilih lokasi usaha warung kopi juga sangan sulit, karena harus memenuhi beberapa kriteria. Untuk menentukan dimana layak dibuka warung kopi maka perlu digunakan suatu sistem pendukukung keputusan (SPK) dengan menggunakan metode Analytical Hierarchy Process(AHP). Penerapan metode AHP untuk membuka warung kopi menggunakan 7 kriteria, yaitu kriteria bangunan toko, air bersih, sarana transportasi, koneksi internet, jarak pusat kota, jarak perkantoran dan sumber listrik. Penelitian ini menggunakan 4 alternative yaitu Simpang Empat, Pasar Inpres, Cunda dan Terminal Pusong. Hasil dari penerapan metode AHP menempatkan Simpang Empat sangat layak untuk dibuka warung kopi. Kata kunci : usaha,warung kopi, SPK,AHP,kriteria, alternative
A review: secondary metabolites of Uvaria chamae p. Beauv. (Annonaceae) and their biological activities
Authors: ABU Thomas , REX-OGBUKU Edia , IDİBİYE Koki
Published: October 2018

Uvaria chamae p. Beauv., synthesizes and accumulates a variety of secondary metabolites from its root,
stem, leaf and fruit. These consist mainly of essential oils, flavonoids, alkaloids
and annonaceous acetogenins. Some of these biologically active secondary
metabolites validate the claim made in traditional system of medicine. The
present review summarizes the information available on the secondary
metabolites isolated from U. chamae and their biological activities.
Cryptocurrencies and Zero Mode Wave guides: An unclouded path to a more contiguous Cannabis sativa L. genome assembly.
Authors: McKernan Kevin , Helbert Yvonne , Kane Liam T. , Ebling Heather , Zhang Lei , Liu Biao , Eaton Zachary , Sun Luo , Dimalanta Eileen T , Kingan Sarah , Baybayan Primo , Press Maximilian Oliver , Barbazuk William , Harkins Timothy
Published: October 2018

We describe the use of a Decentralized Autonomous Organization (DAO) to crypto-fund the single molecule sequencing and publication of a Type II Cannabis plant. This resulted in the construction of the most contiguous Cannabis genome assembly to date. The combined use of the Dash cryptocurrency, DAOs, and Pacific Biosciences sequencing delivered a 1.03 Gb genome with a N50 of 665Kb in 77 days from funding to public upload. This represents a 230 fold improvement in the contiguity of the first cannabis assemblies in 2011 and a 4 fold improvement over all cannabis assemblies to date. 34Gb of additional sequencing pushed the assembly to a N50 of 3.8Mb. Hi-C data from Phase Genomics further scaffolded the assembly to 35 contigs at an N50 of 74Mb but requires additional curation. The genome is partially phased and larger than previously reported (2N = 1.33Gb). The CBCA, THCA and CBDA synthase gene clusters have been phased onto respective contigs demonstrating tandem repeat expansions.
Speech In, Speech Out
Authors: Grimmelmann James
Published: October 2018

This invited short response was published as part of Ronald K.L. Collins and David M. Skover's book Robotica: Speech Rights and Artificial Intelligence (Cambridge University Press 2018). Collins and Skover make a two-step argument about "whether and why First Amendment coverage given to traditional forms of speech should be extended to the data processed and transmitted by robots." First, they assert (based on reader-response literary criticism) that free speech theory can be "intentionless": what matters is a listener's experience of meaning rather than a speaker's intentions. Second, they conclude that therefore utility will become the new First Amendment norm.The premise is right, but the conclusion does not follow. Sometimes robotic transmissions are speech and sometimes they aren't, so the proper question is not "whether and why?" but "when?" Collins and Skover are right that listeners' experiences can substitute for speakers' intentions, and in a technological age this will often be a more principled basis for grounding speech claims. But robotic "speech" can be useful for reasons that are not closely linked to listeners' experiences, and in these cases their proposed "norm of utility" is not really a free speech norm.