bluuebunny/crossref_metadata_2025 huggingface dataset:
ANGIOGRAPHIC EVALUATION OF GRAFT PATENCY AFTER MINIMALLY INVASIVE MULTIVESSEL CORONARY BYPASS SURGERY
Authors: Snegirev M. A. , Paivin A. A. , Denisiuk D. O. , Drozdova O. A. , Mitusova G. M. , Sichinava L. B. , Khvan N. E.
Published: December 2019

The OBJECTIVE was to demonstrate perioperative outcomes and angiographic graft patency rates in the mediumterm period in patients after multivessel minimally invasive coronary artery bypass grafting (MICS CABG) procedures.

MATERIAL AND METHODS. In the period from 2014 to 2019, 270 patients with stable forms of coronary artery disease were operated on. All patients received left internal thoracic artery (LITA) and venous or arterial (radial artery) grafts. Off-pump surgery was performed in 264 cases (97.8 %). 127 patients underwent CT-bypass angiography (CT-BA) on a 128-slice computed tomography at least after 1 year after the operation. Mean follow-up duration was (30.3±7.9) months.

RESULTS. All patients received full myocardial revascularization. Mean number of grafts was (2.6±0.5). Perioperative mortality rate was 0.4 % (1 patient). Perioperative myocardial infarctions or cerebrovascular accident occurred in 3 (1.1 %) and 1 (0.4 %) patients. Overall graft patency rate in examined patients was 89.8 % (290 of 323). At the time of LITA, the patency of mammary grafts was 98.4 % (124 of 126), venous graft –84.0 % (163 of 194) and radial artery grafts – 100 % (3 of 3).

CONCLUSION. MICS CABG was safe and effective and was characterized by minimal rate of perioperative complications. This procedure allowed to achieve complete revascularization of the myocardium without sternotomy and could be performed off-pump (in most cases). MICS CABG provide excellent long-term graft patency rates.

The authors declare no conflict of interest.

The authors confirm that they respect the rights of the people participated in the study, including obtaining informed consent when it is necessary, and the rules of treatment of animals when they are used in the study. Author Guidelines contains the detailed information.
SURGICAL TREATMENT OF RECURRENT HIATAL HERNIAS
Authors: Vasilevsky D. I. , Bechvaya G. T. , Ahmatov A. M.
Published: December 2019

OBJECTIVE. Hiatal hernias are the most common type of visceral anatomy disorder. The unresolved problem of surgical treatment of this pathology remains the high frequency of its relapse. Currently, it is believed that repeated surgical interventions for hiatal hernia are technically difficult, carry a high risk of complications and have unsatisfactory long-term results.

MATERIAL AND METHODS. In the period from 2015 to 2019, 55 patients with this pathology were operated. In 52 (94.5 %) cases, the revision operation was performed laparoscopically, in 3 (5.5 %) – through left-side thoracotomy. The technique of the operation implied the removal of hiatal hernia and the implementation of antireflux reconstruction. In five (9.9 %) patients with a shortened esophagus, the fundoplication wrap was originally created in the chest; in 50 (90.1 %), normal anatomy was restored.

RESULTS. Long-term results ranging from 12 to 48 months were evaluated in 53 (96.4 %) cases. The natural position of the esophagus and stomach in relation to the diaphragm was detected in 43 (81.1 %) patients, relapse of hiatal hernia – in 5 (9.4 %). In 5 patients, the fundoplication wrap formed in the chest was functional. The absence of gastroesophageal reflux was observed in 41 (91.8 % of patients who had GERD before surgery). In 4 (8.8 %) cases, including one patient with antireflux reconstruction in the chest, a relapse of the disease occurred.

CONCLUSION. The presented results allowed the surgical treatment of recurrent hiatal hernias reasonable and effective.

The authors declare no conflict of interest.

The authors confirm that they respect the rights of the people participated in the study, including obtaining informed consent when it is necessary, and the rules of treatment of animals when they are used in the study. Author Guidelines contains the detailed information.
TOTAL MESORECTUMECTOMY IN THE SURGICAL TREATMENT OF RECTAL CANCER: OPEN OR LAPAROSCOPIC?
Authors: Azimov E. G. , Aliyev S. A.
Published: December 2019

The OBJECTIVE of the work was to evaluate the long-term results of surgical treatment of patients underwent open and laparoscopic TME for rectal cancer.

MATERIAL AND METHODS. The analysis of the results of surgical treatment of 103 patients aged from 20 to 70 years with rectal cancer was presented. Depending on the methods of total mesorectumectomy (ТМЕ), patients were divided into 2 groups. The 1st group included 47 (45.6 %) patients who had underwent laparoscopic total mesorectumectomy (LTME). The 2nd group included 56 patients who had underwent open total mesorectumectomy (OTME). In all patients, the histological structure of the tumor was represented by adenocarcinoma of varying degrees of differentiation. Long-term results of surgical treatment with actual and relapse-free 3-and 5-years survival were observed in 97 (94.2 %) patients.

RESULTS. The frequency of local relapses of RC after OTME and LTME was 11.5 % (6 patients) and 11.1 % (5 patients). Distant metastases were detected in 7.7 (4 patients) and 6.7 % (3 patients) of cases, respectively. The actual 3-year survival rate of patients after LTME was 80 %/, 5-year-57.8 %. In patients underwent OTME, these indicators were 81.8 and 54.5 %, respectively.

CONCLUSION. A significant correlation was found between the recurrence rate and distant metastases of the RC and the histological structure and degree of tumor differentiation. The differences between the three-year survival rates of patients in both groups are not statistically significant (p>0.05).

The authors declare no conflict of interest.

The authors confirm that they respect the rights of the people participated in the study, including obtaining informed consent when it is necessary, and the rules of treatment of animals when they are used in the study. Author Guidelines contains the detailed information.
RESULTS OF EMERGENCY SURGICAL INTERVENTIONS FOR COLORECTAL CANCER COMPLICATED BY BLEEDING
Authors: Schaeva S. N.
Published: December 2019

The OBJECTIVE was to evaluate oncological results of five-year survival of patients with colorectal cancer (CRC) complicated by bleeding who underwent emergency resections.

MATERIAL AND METHODS. The study included the data of 240 patients with CRC complicated by bleeding treated in General and specialized surgical hospitals in Smolensk between 2001 and 2013 (13 years).

RESULTS. Of 240 patients with CRC complicated by bleeding, 233 underwent emergency resections. Statistically significant differences were revealed in R1 and the number of investigated lymph nodes between the coloproctological and General surgical hospitals (p=0.01, p<0.001) and oncological and General surgical hospitals (p=0.016, p<0.0001). The indicators of 5-year overall and relapse-free survival were more in patients who had underwent emergency surgical interventions in specialized hospitals (p=0.00217, p=0.0143).

CONCLUSION. When bleeding from the tumor, the mortality rate after surgery was 17.9%, the frequency of severe postoperative complications (IIIb-IVb complications according to Clavien-Dindo) – 44.7%.

The authors declare no conflict of interest.

The authors confirm that they respect the rights of the people participated in the study, including obtaining informed consent when it is necessary, and the rules of treatment of animals when they are used in the study. Author Guidelines contains the detailed information.
Rectifying Revisionism: Canadian National Identity and War Commemoration
Authors: Mountford Shamus
Published: December 2019

Canadians have been given the torch, but are failing to hold it high, and are therefore breaking faith with those who died. This paper will argue that this phenomenon is primarily due to eroding remembrance of Canadian military heritage, through the weaponization of the ‘peacekeeping myth,’ and the geographic reality of continental separation from war cemeteries. With the aim to heal the damages of past revisionism regarding Canadian military heritage as a component of Canadian national identity, a standardized, national commemoration curriculum will be proposed, to ensure that our sacred pact to hold the torch high, is fulfilled.
How Does Canada’s Decentralized Federation Impact Environmental Regulations
Authors: Khan Reeba
Published: December 2019

This paper argues Canada’s decentralized federation plays an influential role in thwarting environmental regulations at the federal and provincial levels of government. The text is structured as follows: the author’s argument comes first, which is followed by an opposing viewpoint and a subsequent rebuttal reaffirming the author’s stance. The paper’s evidence is based on scholarly journal articles, lectures, and textbooks. The author’s arguments build on the Constitution’s ambiguity regarding environmental responsibilities: the ambiguity promotes a piecemeal approach to environmental regulations at the provincial level. This results in unsynchronized policies across Canada which weakens the overall efficacy of the environmental policies. Moreover, despite attempts at clarifying environmental responsibilities there is still dissonance because Canada is a decentralized federation. Subsequently, the federal government cannot force synchronization or compliance. Furthermore, at times, the federal government must underplay its hand even when it takes constitutionally charged actions because sound environmental actions require provincial actions as well. Ultimately, this paper showcases how decentralized federalism plays federal and provincial level governments against each other when it comes to environmental regulations. This results in poor environmental policies at all levels of government.
Relações entre as características associadas à mensuração de desempenho e as Escolas de Pensamento Estratégico
Authors: Cunha Callado Aldo Leonardo , Silva Aline Romão da
Published: December 2019

O objetivo deste trabalho foi analisar as relações entre as características de empresas pertencentes ao setor da construção civil e critérios de mensuração de desempenho e as Escolas de Pensamento Estratégico. A pesquisa se classifica como descritiva e, predominantemente, quantitativa. Para a sua operacionalização, foi aplicado um questionário estruturado com gestores de 29 empresas, o qual foi dividido em três grupos de variáveis. O primeiro foi composto por fatores relacionados às características das empresas participantes. O segundo foi formado por fatores relacionados aos critérios de mensuração de desempenho adotados pelas organizações. E o último, por Escolas de Pensamento Estratégico, a saber: Design, Planejamento, Posicionamento, Empreendedora, Cognitiva, Aprendizado, Poder, Cultural, Ambiental e Configuração. Para o tratamento dos dados coletados, foram utilizadas duas técnicas estatísticas: análise descritiva das variáveis e a aplicação do Coeficiente de Spearman, para investigar as possíveis associações entre os fatores considerados e as escolas supracitadas. Os resultados demonstraram uma relação significativa entre uma característica das empresas e a Escola do Aprendizado. No entanto, os resultados demonstram que há relações em maior proporção associadas aos critérios de mensuração adotados, visto que, todos os fatores investigados se mostraram relacionados a, no mínimo, uma Escola de Pensamento Estratégico.
Diagnóstico Inicial para Estabelecimento de Critérios no Pagamento de Taxas de Inscrições de Servidores para Eventos Externos: O Caso da Pró-Reitoria de Gestão de Pessoas da Universidade Federal de Santa Maria
Authors: Fighera Andressa , Sório Géssica Lovato , Roth Henrique , Pinto Nelson Guilherme Machado
Published: December 2019

Pretende-se neste artigo descrever e analisar os investimentos da Pró-Reitoria de Gestão de Pessoas (PROGEP) da Universidade Federal de Santa Maria em taxas de inscrições de servidores para eventos externos. Para isso a metodologia utilizada no estudo é de uma pesquisa quantitativa descritiva, os dados analisados foram obtidos através dos relatórios emitidos pelo SIE – Sistema de Informações e Ensino da UFSM, referentes aos empenhos efetuados para pagamento de taxas de inscrições de servidores no período compreendido entre 2008 e 2015. Os resultados demonstraram que os investimentos da PROGEP em taxas de inscrição para servidores em eventos externos foram realizados sem uniformidade entre as unidades da UFSM. As diferenças se apresentaram em diversos fatores como setores, cargos (docentes ou técnicos administrativos). Assim, para diminuir a disparidade no investimento em taxas de inscrição, conclui-se que a PROGEP deve padronizar critérios claros de distribuição destes recursos.
A DIDÁTICA UTILIZADA PELOS PROFESSORES NA EDUCAÇÃO SUPERIOR E SEUS IMPACTOS NA APRENDIZAGEM DOS ESTUDANTES
Authors: Fontanini Carlos Augusto , Choti Deise Maria Marques , Miers Marina
Published: December 2019

O objetivo desta pesquisa é apresentar os resultados sobre a didática utilizada pelos professores na Educação Superior e seus impactos na aprendizagem dos estudantes. O campo da didática, segundo alguns autores, está restrito ao desenvolvimento de técnicas voltadas ao ensino, como instrumentos para o desenvolvimento no processo de ensinar, com vistas ao melhor desempenho e resultados eficazes (SFORNI, 2012; PIMENTA e ANASTASIOU, 2012; HAYDT, 2011). Para a coleta de dados foi utilizado o ResearchGate. A partir de uma pergunta feita no ResearchGate, centenas de pesquisadores ao redor do mundo, de diferentes universidades, tiveram a oportunidade de respondê-la e manifestarem suas opiniões a respeito. A pergunta que deu origem a coleta de dados foi: O professor deveria focar em uma aprendizagem rigorosa ou em uma aprendizagem com entretenimento? Foram analisadas setenta por cento das respostas, das quais pôde-se extrair entre opiniões e até mesmo replicações em debates, 104 respostas sintetizadas, o que é uma amostra considerável. Os resultados apontam que é necessário utilizar das tecnologias advindas da globalização a favor do ensino. Deve-se apropriar das novidades tecnológicas e da nova maneira de se viver e olhar o mundo. Novas gerações estão envolvidas com novas tecnologias desde muito cedo, sendo necessário que se estabeleça uma forma de utilização destes recursos, de forma envolvente e motivadora.
MEDIUM-TERM AND LONG-TERM PLANNING OF MEDICAL SUPPORT FOR TROOPS (FORCES) AND AFFECTED POPULATION AT ELIMINATION OF MEDICAL AND SANITARY CONSEQUENCES OF EMERGENCY SITUATIONS
Authors: Dmitriev G. V. , Lemeshkin R. N. , Savchenko I. F. , Stepanov A. V.
Published: December 2019

Relevance. Currently, the solution to the problem of medical support for troops (forces) and the population during the liquidation of the health consequences of emergencies by forces and means of the medical service of the Armed Forces of the Russian Federation does not lose its relevance.

Intention. The system-morphological method to create a multidimensional morphological matrix with the corresponding morphological features and develop solutions to the problem of medical support in responding to the health consequences of emergencies.

Methodology. The methodology of system-morphological analysis is presented, which allows creating alternative solutions. Variants of medical support for troops (forces) and the population were developed during the liquidation of the health consequences of emergency situations of a natural, technogenic and social nature: “Departmental”, “Interdepartmental”, “International”. In relation to each option, 9 indicators (criteria) are proposed: normative legal regulation; system controllability; complexity of organizing the system; resource (material) cost; staffing; the adequacy of medical care; efficiency; experience and innovation; autonomy of action. To achieve the goal of the study, the original MPRIORITY 1.0 dialog system (MY PRIORITY) was used which implements a method for analyzing hierarchies through repetitions (iterations).

Results and Discussion. The results characterize each of the considered alternative options with an appropriate weight priority, and their preference is determined. During the first iteration, priorities were identified for a system of indicators and criteria that are characteristic for achieving a result with an emphasis on normative legal regulation of activities with its organizational structure and management system. In the second one, the priorities for the system of indicators and criteria were changed with a focus on the organization of medical care with the existing system of material and technical support, medical supply, as well as the proper level of training of medical personnel.

Conclusion Proposals have been developed for the medical service of the Armed Forces of the Russian Federation, in particular for the Service for Disaster Medicine of the Ministry of Defense of Russia, on the organization of a medical support system for troops (forces) and the population during mitigation of the health consequences of emergencies.
CASES OF MORBIDITY WITH WORK DAYS LOST AMONG EMPLOYEES OF THE EMERCOM OF RUSSIA AND THE WORKING POPULATION IN RUSSIA
Authors: Evdokimov V. I. , Bobrinev E. V.
Published: December 2019

Relevance. Activities in extreme conditions likely involve stress on functional reserves and impaired health. Intention. Calculate the medical and statistical indicators of cases of morbidity with work days lost among employees of the EMERCOM of Russia and compare the above indicators with the working population in Russia in 2010–2015.

Methodology. We analyzed cases of morbidity with temporary disability in employees of the EMERCOM of Russia units according to the automated database of the All-Russian Order of the Badge of Honor Research Institute for Fire Protection, EMERCOM of Russia, over 2010–2015 in about 80% of all employees who had special military ranks: senior commanding officers (officers, warrant officers), junior commanding officers (sergeants) and rank and file. The indicators are calculated per 1000 employees or in ‰. Cases of morbidity correlated with the International Classification of Diseases and Behavioral Disorders of the 10th Revision (ICD-10). Cases of temporary disability of workers in Russia was obtained from the database of the Unified Interdepartmental Information and Statistical System of Russia.

Results and analysis.  The average annual level of morbidity cases with work days lost among the personnel of the EMERCOM of Russia was (374.2 ± 9.6) ‰, including (345.2 ± 9.1) among the employees of the Federal Fire Service, (361.4 ± 28.3) ‰ in the Main Inspectorate for Small Boats, (339.3 ± 20.5) ‰ in the Search and Rescue Units, and (867.6 ± 97.6) ‰ in the Rescue Military Units. In the structure of cases of work days lost in the EMERCOM of Russia, the shares of employees of the divisions were distributed as follows: 81.5, 2.8, 2.1 and 13.6 %, respectively. The leading classes of diseases among the personnel of the EMERCOM of Russia were: respiratory diseases (Chapter X) with morbidity rate (167.7 ± 8.2) ‰ and 44.7% in the structure; injuries, poisoning and some other consequences of external causes (Chapter XIX) (41.8 ± 1.4) ‰ and 11.2 %; diseases of the musculoskeletal system and connective tissue (Chapter XIII) – (34.7 ± 1.2) ‰ and 9.3%; circulatory system diseases (Chapter IX) – (25.2 ± 1.6) ‰ and 6.7%; and some infectious and parasitic diseases (Chapter I) – (21.9 ± 2.9) ‰ and 5.9 %. For workers in Russia, the average annual level of morbidity cases with work days lost 1.4 times as high: (522.5 ± 28.1) ‰ (p < 0.01). The consistency of the indicators is high, negative, and approaches statistical significance (r = –0.75; p < 0.1), which may indicate the influence of multidirectional factors in the formation of cases of work days lost among the EMERCOM of Russia employees and working population in Russia. Trends over time, structure and morbidity rates for cases with work days lost among employees of the EMERCOM of Russia divisions are presented.

Conclusion. Accounting for morbidity indicators with work days lost can contribute to a more rational allocation of resources during the operational activities of the EMERCOM of Russia.
RISKY SEXUAL BEHAVIOR IN PEOPLE LIVING WITH HIV
Authors: Antonova D. V. , Bocharov V. V. , Chrustaleva N. S.
Published: December 2019

Relevance. There is a continuing growth of infection with the human immunodeficiency virus (HIV) and the need for effective design of preventive measures.

Intention. To explore features of risky sexual behavior in people living with HIV with and without substance abuse and in healthy respondents.

Methodology. The study involved 136 individuals in the groups as follows: 1st (n = 50) – drug users with blood-borne HIV infection, 2nd (n = 50) – heterosexual HIV infection, 3rd (n = 36) – without HIV infection. A specially developed clinical map was used, as well as an original questionnaire recording the characteristics of risky behavior and the main characteristics of the life situation of the disease (“Infection risk and the disease situation”). Statistical data processing included the Fisher criterion (ϕ-criterion).

Results and Discussion. The characteristics of respondents’ sexual behavior related to gender, the presence/absence of HIV and the transmission route were revealed in the study. It has been established that HIV-infected and healthy respondents do not differ in the frequency of barrier protection methods (condoms) use. Various variants of risky sexual behavior were noted in all groups, in particular, unjustified rejection of condoms. The results are partially confirmed in the published data. In the Russian sample, non-use of condoms and the prevalence of “trust in a partner” were studied for the first time.

Conclusion. Important components of prevention programs include increasing sexual literacy and working with people who use psychostimulants and other drugs.
Engelli Çocuklara Yönelik Yerel Kamu Politikalarının Yönetişim Anlayışı Çerçevesinde Planlanması
Authors: ZENGİN Eyüp
Published: December 2019

Bu çalışmada, yerel yönetimler ve
engelli çocuklar hakkında bilgi verildikten sonra, yerel yönetişim ve yerel
kamu politikalarının özellikleri üzerinde durulacak ardından, engelli çocuklara
yönelik yerel kamu politikalarının yönetişim anlayışı çerçevesinde planlanması
ve yürütülen/yürütülmesi gereken çalışmalar değerlendirilecektir.

 

Engelli çocuklar için
geliştirilmesi gereken yerel po­litikaların eşit vatandaşlık çerçevesinde, farklılıkların
göz önünde bulundurulması ve tahammül edilmesi temelinde planlanması ve
uygulanması gerekmektedir. Engelli bireylerin günlük yaşamda karşılaştıkları
sorunların önemli bir bölümünü yerel düzeydeki politika ve uygulamalardan
kaynaklanmaktadır. Bu çerçevede, ilgili mevzuatta yer alan düzenlemeler
değerlendirilmeli bu düzenlemelerin etkin bir biçimde nasıl ve ne şekilde
uygulanması gerektiği üzerinde durulması gerekmektedir.

 

Hayatta kalma ve gelişip büyüme
engelli çocuklar için özellikle güç olabilir. Yoksul kalma riskleri, engeli
olmayan yaşıtlarına göre daha büyüktür. Çocukların aynı dezavantajlarla –
örneğin yoksulluk ya da belirli bir azınlık gruba mensup olma gibi-
karşılaştıkları durumlarda bile, kendi özellikleri ve toplumun önlerine diktiği
birçok engel nedeniyle engelli çocuklar ek güçlüklerle karşılaşmaktadır.

 

 

Yönetişim, hesap verebilirlik,
katılımcılık, şeffaflık gibi belirli ilkelerin uygulanmasını gerektiren bir
anlayışa sahiptir. Yerel yönetişim, yerel seviyedeki görev ve sorumlulukların
yerine getirilmesi amacıyla, farklı düzeylerde, farklı yetkilere sahip yerel
kuruluşlar ile vatandaşlar arasında güçbirliği, işbirliği ve etkileşim oluşturma
sürecidir.
Enerji Yatırımlarında Sosyal Kabulü Etkileyen Faktörlerin Değerlendirilmesi
Authors: EKŞİ Ali , KANTARLI İsmail Cem , ATALAY YALÇIN Fulya , KİRAZLI Gülce
Published: December 2019

Bu çalışmada, enerji yatırımlarında sosyal kabulü etkileyen faktörlerin değerlendirilmesi amaçlanmaktadır. Çalışmada İzmir Bornova ilçe merkezi evren olarak belirlenmiş, 18 yaş ve üzeri bireyler kapsama alınmıştır. Örneklem, basit rastgele örneklem seçim yöntemiyle belirlenen 236 kişiden oluşmuştur. Toplanan veriler SPSS 16,0 istatistik programı kullanılarak analiz edilmiş, veri çözümlenmesinde frekans dağılımı ve yüzdelerden yararlanılmış, değişkenler arasındaki farkın belirlenmesinde ki-kare testi kullanılmıştır. Yapılan çalışmada yenilenebilir enerji yatırımlarına yönelik sosyal kabul, konvansiyonel enerji üretim yatırımlarına göre daha yüksektir. En düşük sosyal kabul oranı nükleer enerji yatırımlarındayken, özellikle jeotermal yatırımlara karşı kabulün düşüklüğü dikkat çekicidir. Sosyal kabulde etkili faktörler olarak, yatırımın yaşam alanına uzaklığı, doğal çevreye, insan sağlına ve tarım alanlarına olumsuz etkileri belirleyici olarak görülmektedir. Enerji yatırımlarında sosyal kabul, yatırımı engelleyici ya da geciktirici bir faktör olarak değerlendirilmemeli, tam tersi enerji yatırımlarında kamusal yararın sağlanması adına önemsenmesi gereken bir faktör olarak görülmelidir. Kamu idaresi tarafından katılım mekanizmalarının kolaylaştırılması ve etkin bilgilendirmenin sağlanması, enerji yatırımına karşı sosyal kabulün artmasına katkı sağlamaktadır.
Resolving the Quadruple Bonding Conundrum in C2 Using Insights Derived from Excited State Potential Energy Surfaces: A Molecular Orbital Perspective
Authors: Bhattacharjee Ishita , Ghosh Debashree , Paul Ankan
Published: December 2019

The question of quadruple bonding in C2 has emerged as a hot button issue, with opinions sharply divided between the practitioners of Valence Bond (VB) and Molecular Orbital (MO) theory. Here, we have systematically studied the Potential Energy Curves (PECs) of low lying high spin sigma states of C2, N2 and Be2 and HC≡CH using several MO based techniques such as CASSCF, RASSCF and MRCI. The analyses of the PECs for the 2S+1Σg/u (with 2S+1=1,3,5,7,9) states of C2 and comparisons with those of relevant dimers and the respective wavefunctions were conducted. We contend that unlike in the case of N2 and HC≡CH, the presence of a deep minimum in the 7Σ state of C2 and CN+ suggest a latent quadruple bonding nature in these two dimers. Hence, we have struck a reconciliatory note between the MO and VB approaches. The evidence provided by us can be experimentally verified, thus providing the window so that the narrative can move beyond theoretical conjectures.
para-Selective Cyanation of Arenes by H-Bonded Template
Authors: Pimparkar Sandeep , Bhattacharya Trisha , Maji Arun , Saha Argha , Jayarajan Ramasamy , Dutta Uttam , Lu Gang , Lupton David , Maiti Debabrata
Published: December 2019

The significance of site selective functionalization stands upon the superior selectivity, easy synthesis and diverse product utility. In this work we demonstrate the para-selective introduction of versatile nitrile moiety, enabled by detachable and reusable H-bonded auxiliary. The methodology holds its efficiency irrespective of substrate electronic bias. The conspicuous shift in the step energetics was probed by both experimental and computational mechanistic tools heralds the inception of para-deuteration. The synthetic impact of the methodology was highlighted with reusability of directing group and post synthetic modifications
Torquoselectivity of the Ring-Opening Reaction of 3,3-Dihalosubstituted Cyclobutenes: Lone Pair Repulsion and Cyclic Orbital Interaction
Authors: Naruse Yuji , Takamori Atsushi
Published: December 2019

Three major factors determine torquoselectivity, which is the diastereoselectivity in electrocyclic ring-opening reactions to produce E/Z-double bond(s). One is the interaction between the decomposing sCC bond and low-lying vacant orbital(s), such as a p*- or s*-orbital on the substituent, which promotes the reaction, resulting in inward rotation of the substituent. Second, for a substituent with a lone pair(s), repulsive interaction between the decomposing s-bond and the lone pair(s) hinders inward rotation, so that the products of outward rotation should be preferred. Finally, a more strongly donating s-electron-donating group (sEDG) rotates inwardly due to stabilization by phase-continuous cyclic orbital interaction. We compared the latter two interactions, repulsion between the lone pairs on the substituent and stabilization from phase-continuous cyclic orbital interaction, to determine which has a greater effect on the diastereoselectivity. We considered a series of model reactions with halogen substituents, and concluded that the diastereoselectivity is mainly controlled by cyclic orbital interaction.
Information technologies-the basis of training, retraining and advanced training systems for helicopter pilots
Authors: Borisov Yu. A. , Rybkin P. N. , Chinyuchin Yu. M.
Published: December 2019

In the early 90s there was a need for the complex development of training, retraining, maintaining and professional development system designed for the most popular Mi-8 helicopter pilots oriented at modern information technologies. The system covers all the stages of pilot training, starting with the initial stages of professional activity up to its completion. The technical means compiling specifications for the whole range training were determined by the results of the pilot in-flight activity analysis. The proposed optimal range of technical facilities for training consists of technical means with different levels of out-of-cockpit and in-cockpit environment simulation. The utilization of these means allows to minimize the expenditures on proficiency level support and cost of pilot training. The set of technical training appliances such as: automated training courses of theoretical disciplines, computer functional and situational simulators, navigation simulators and flight complex simulator includes the facilities that provide training of the pilot actions at each stage of the flight. The individual schedule of computer based self-development classes is drawn up for each student. While compiling the individual schedule logical sequence of all training stages was carefully observed: firstly we begin with a thorough study of helicopter structure, then goes the study of functional system or equipment normal operation, functional system or equipment in special situations operation, and finally, the routine technology of crew operation in normal flight conditions and the crew actions in dangerous and emergency situations. In addition to the direct training of students, the initial stage of training solved the tasks of practical check and improvement of previously taken decisions.
The development of advanced network simulators for air transport by using fuzzy models and noise-resistant coding
Authors: Gladkih A. A. , Bolshedvorskaya L. G. , Volkov An. K. , Volkov Al. K.
Published: December 2019

The article analyzes foreign experience and concludes that one of the ways to improve the efficiency of aviation security in the Russian Federation is to use modern network training complexes. A new approach to the assessment of the competence of the aviation security screeners was proposed and tested, that allows to take into account the parameters of the oculomotor activity and heart rate variability of the aviation security screeners being tested, different from the existing approaches using fuzzy classification models. The eye-tracking technology and the device of psychophysiological testing UPFT-1/30 "Psychophysiologist" were used as instruments of psychophysiological monitoring. The basics of automatic generation of fuzzy models such as Sugeno and Mamdani from experimental data are presented. Experimental studies were conducted on the basis of the Ulyanovsk Civil Aviation Institute. The results of the comparison of the generated models showed that the Sugeno model trained with the use of ANFIS-algorithm is more accurate than the Mamdani model and the linear regression model identifies the dependence being studied, according to the competence of aviation security screeners. As a criterion of quality of models on training and test data the average square error is used. The actual problem of choosing an effective concept of noise-resistant coding in the telecommunication component of advanced training complexes is substantiated. The ways of solving the important problem of increasing the reliability of actual digital data in network training complexes based on the use of noise-resistant coding are described. A model of permutation decoder of non-binary redundant code based on lexicographic cognitive map is presented. This model of redundant code decoder uses methods of cognitive data processing in the implementation of the procedure of permutation decoding to effectively protect remote control commands from the influence of destructive factors on the control process.
Multi-rotor helicopter type platform capacities research
Authors: Buzuluk V. I. , Kosushkin K. G. , Mavritsky V. I.
Published: December 2019

The development of multi-rotor helicopter concepts, driven by the active introduction of brushless electric motors, leads to the necessity of assessing the multi-rotor scheme main advantages implementing possibility and determining the rational areas of its application. The article analyzes the concept of a multi-rotor platform with a distributed power plant. Parametric study of characteristics depending on the number of rotors for a line of multi-propeller aircraft with take-off weight from 0.5 to 120 tons was carried out. Evaluation of weight and dimensional characteristics of blades, main rotor heads, gear boxes, as well as power wires of electric motors and structure beams connecting the elements of the distributed power plant is obtained. Evaluation of drag and thrust losses on blowing, as well as power requirements for typical flight modes was carried out. Estimation of the required number of rotors for the implementation of the gearless condition and flight safety with one engine failed are obtained. Rational areas of multi-rotor scheme application are defined.
Loss of autophagy impairs physiological steatosis by accumulation of NCoR1
Authors: Takahashi Shun-saku , Sou Yu-Shin , Saito Tetsuya , Kuma Akiko , Yabe Takayuki , Sugiura Yuki , Lee Hyeon-Cheol , Suematsu Makoto , Yokomizo Takehiko , Koike Masato , Terai Shuji , Mizushima Noboru , Waguri Satoshi , Komatsu Masaaki
Published: December 2019

Lipid droplets (LDs) are dynamic organelles that store neutral lipids during times of energy excess, such as after a meal. LDs serve as an energy reservoir during fasting and have a buffering capacity that prevents lipotoxicity. Autophagy and the autophagic machinery have been proposed to play a role in LD biogenesis, but the underlying molecular mechanism remains unclear. Here, we show that when nuclear receptor co-repressor 1 (NCoR1), which inhibits the transactivation of nuclear receptors, accumulates because of autophagy suppression, LDs decrease in size and number. Ablation of ATG7, a gene essential for autophagy, suppressed the expression of gene targets of liver X receptor α, a nuclear receptor responsible for fatty acid and triglyceride synthesis in an NCoR1-dependent manner. LD accumulation in response to fasting and after hepatectomy was hampered by the suppression of autophagy. These results suggest that autophagy controls physiological hepatosteatosis by fine-tuning NCoR1 protein levels.
CLIC4 and CLIC1 bridge plasma membrane and cortical actin network for a successful cytokinesis
Authors: Uretmen Kagiali Zeynep Cansu , Saner Nazan , Akdag Mehmet , Sanal Erdem , Degirmenci Beste Senem , Mollaoglu Gurkan , Ozlu Nurhan
Published: December 2019

CLIC4 and CLIC1 are members of the well-conserved chloride intracellular channel proteins (CLICs) structurally related to glutathione-S-transferases. Here, we report new roles of CLICs in cytokinesis. At the onset of cytokinesis, CLIC4 accumulates at the cleavage furrow and later localizes to the midbody in a RhoA-dependent manner. The cell cycle–dependent localization of CLIC4 is abolished when its glutathione S-transferase activity–related residues (C35A and F37D) are mutated. Ezrin, anillin, and ALIX are identified as interaction partners of CLIC4 at the cleavage furrow and midbody. Strikingly, CLIC4 facilitates the activation of ezrin at the cleavage furrow and reciprocally inhibition of ezrin activation diminishes the translocation of CLIC4 to the cleavage furrow. Furthermore, knockouts of CLIC4and CLIC1 cause abnormal blebbing at the polar cortex and regression of the cleavage furrow at late cytokinesis leading to multinucleated cells. We conclude that CLIC4 and CLIC1 function together with ezrin where they bridge plasma membrane and actin cytoskeleton at the polar cortex and cleavage furrow to promote cortical stability and successful completion of cytokinesis in mammalian cells.
Some Applications of Higher Order Generalized α− Difference Operator
Authors: S Gokulakrishnan , V Chandrasekar
Published: December 2019

In this paper, we derive the discrete version of the Bernoulli’s formula according to the generalized α- difference operator for negative `l ,and to find the sum of several type of arithmetic series in the field of Numerical Methods. Suitable example are provided to illustrate the main results.
Hubungan Pemberian Syringe Pump Norepinephrine dengan Kadar Gula Darah Acak pada Pasien di Ruang ICU RSUD Mardi Waluyo Kota Blitar
Authors: Prasetya Yuda Dwi , Arsa Sandi Alfa Wiga
Published: December 2019

Ketidakwaspadaan terhadap kontrol gula pasien yang mendapatkan norepinephrine berakibat perpanjangan masa rawat inap dan perburukan kondisi.Tujuan penelitian adalah menganalisis hubungan pemberian syringe pump norepinephrine dengan kadar gula darah acak pada pasien di ruang ICU RSUD Mardi Waluyo Kota Blitar. Rancangan penelitian menggunakan korelasi dengan pendekatan cross sectional. Populasi dalam penelitian ini adalah semua pasien ICU RSUD Mardi waluyo Kota Blitar yang diberikan syringe pump norepinephrine pada 29 Oktober â€“ 22 November 2018. Jumlah sampel penelitian sebanyak 30 orang dengan menggunakan tehnik pengambilan sampel accidental sampling. Analisa data menggunakan Spearmanâ€™s rho. Hasil penelitian menunjukan ada hubungan yang lemah antara pemberian syringe pump norepinephrine dengan kadar gula darah acak pada pasien di ruang ICU RSUD Mardi Waluyo Kota Blitar dengan p value = 0,034 dan rs = 0,389. Norepinephrine dapat meningkatkan tekanan darah pada pasien kritis yang mengalami hipotensi, akan tetapi berakibat meningkatkan kadar gula darah acak, sehingga diharapkan adanya pemantauan kadar gula darah acak pada pasien kritis serta adanya monitoring penggunaan cairan diluent normal saline 0,9% dan Â dextrose 5% yang harus disesuaikan dengan kondisi dari pasien yang mendapatkan norepinephrine.Â Unawareness of blood sugar control in patients receiving norepinephrine resulted in an extended period of hospitalization and worsening conditions. The aim of the study was to analyze the correlation of giving norepinephrine syringe pump and random blood sugar levels of patients in ICU Mardi Waluyo Hospital, Blitar City. The study used correlation design with cross sectional approach. The population in this study was all ICU patients of Mardi Waluyo Hospital Blitar City who were given the norepinephrine syringe pump on 29 October - 22 November 2018. The sample was 30 people taken by using accidental sampling technique. The data analysis used Spearman's. The results showed there was a weak correlation between the administration of norepinephrine syringe pump and random blood sugar levels of patients in the ICU room at Mardi Waluyo Hospital, Blitar City with p value = 0.034 and rs = 0.389. Norepinephrine could increase blood pressure in critical patients who had hypotension, but it resulted in the increase of random blood sugar levels. It is expected to monitor random blood sugar level of critical patients as well as monitoring the use of diluent normal saline 0.9% and dextrose 5% which should be adapted to the conditions of patients who get norepinephrine.
Peran Petugas Kesehatan Dalam Upaya Pencegahan Kanker Serviks Melalui Peningkatan Cakupan Pemeriksaan Inspeksi Visual Asam Asetat (IVA) di Kelurahan Campurejo Kecamatan Kota Kediri
Authors: Fadhillah Is , Indita Wiwen
Published: December 2019

Pada saat ini tenaga kesehatan mempunyai tugas besar dalam peranannya terhadap penanggulangan kanker cerviks. Salah satu masalah utama kesehatan reproduksi perempuan di Indonesia adalah kanker serviks. Angka kejadian di seluruh dunia mencapai 490.000 kasus kanker cerviks dan mengakibatkan 240.000 kematian tiap tahunnya, dan 80% dari angka itu yaitu sekitar 392.000 terjadi di wilayah Asia (Soebachman, 2011) Menurut data dari Indonesia (Kemenkes RI) pada tahun 2013, kejadian kanker serviks di Indonesia sebesar 0,8%. Provinsi yang memiliki estimasiÂ  jumlahÂ  penderitaÂ  kankerÂ  serviks terbesar adalah Provinsi Jawa Timur denganÂ  estimasiÂ  21.313Â  kasus (Kemenkes RI, 2015). ProgramÂ  IVA akan mengurangi risiko terkena kanker serviks, dimana ibu-ibu dapat melakukanÂ Â  pemeriksaan IVA sebagai upaya pencegahan sejak dini. Penelitian ini bertujuan untuk mendiskripsikan pemahaman tenaga kesehatan di wilayah Kota Kediri terhadap masalah kanker serviks, serta mengidentifikasi upaya-upaya apa saja yang dilakukan tenaga kesehatan dalam melakukan pencegahan terhadap kanker serviks melaluiÂ  peningkatan cakupan pemeriksaan IVA di Kelurahan Campurejo Kecamatan Mojoroto Kota Kediri. Penelitian ini menggunakan metode kualitatif. Analisis data dalam penelitian ini menggunakan analisis kualitatif interaktif (Milles dan Haberman). Dari hasil penelitian dapat dirangkumkan beberapa faktor yang menyebabkan keberadaan kanker serviks melalui pemahaman petugas kesehatan diantaranya yaitu: kebersihan organ intim, gonta-ganti pasangan, faktor genetik,hubungan seks di luar nikah,pernikahan dini. Peran dan strategi tenaga kesehatan dalan pencegahan kanker serviksÂ  yaitu melaui Promosi penyuluhan, membentuk tim, sosialisasi, lintas sektor, model kampung IVA, pemeriksaan gratis.
Hubungan Tingkat Kecacatan dan Lama Menderita Kusta dengan Depresi Penderita dan Mantan Penderita Kusta
Authors: Wulandari Nawang , Su'udi Muhammad
Published: December 2019

Sifat penyakit yang kronis dan kecacatan yang ditimbulkan dari penyakit kusta dapat mengganggu penampilan dan fungsi tubuh penderitanya, ditambah persepsi yang negatif dari masyarakat menimbulkan dampak negatif dalam kesehatan jiwa. Penderita akan merasa rendah diri, tekanan batin dan merasa tidak berguna baik dalam lingkungan keluarga maupun masyarakat, kondisi ini yang dapat mencetuskan depresi. Penelitian ini bertujuan untuk mengetahui hubungan antara tingkat kecacatan dan lama menderita dengan depresi penderita dan mantan penderita kusta di Kecamatan Ponggok Kabupaten Blitar. Jenis penelitian ini adalah analitik observasional dengan pendekatan cross sectional. Sampel yang digunakan sebanyak 26 responden diambil dengan teknik purposive sampling. Metode pengambilan data menggunakan kuesioner Zung Self-Rating Depression Scale (ZSDS) dan dianalisis menggunakan uji korelasi Spearman. Hasil analisis tingkat kecacatan dan lama menderita dengan depresi sama-sama didapatkan nilai p<0,05 yang berarti ada hubungan antara tingkat kecacatan dan lama menderita dengan depresi penderita dan mantan penderita kusta. Depresi dipengaruhi oleh banyak faktor diantaranya pendidikan, jenis kelamin, status perkawinan, dukungan, pendapatan, dan karakteristik penyakit sendiri. Peningkatan ketahanan terhadap depresi melalui self efficacy sangat diperlukan untuk meningkatkatkan kepercayaan diri penderita dan mantan penderita dalam mengatasi masalahnya.Â The chronic nature of disease and disability resulting from leprosy can disrupt the appearance and function of the sufferer's body, and the negative perception of the community has a negative impact on mental health. Patients will feel inferior, inner pressure and feel useless in both the family and community environment, this condition can trigger depression. This study aims to determine the relationship between the level of disability and length of suffering with depression sufferers and former leprosy sufferers in Ponggok District Blitar. This type of research is observational analytic with cross sectional approach. The sample used by 26 respondents was taken by purposive sampling technique. The data collection method uses the Zung Self-Rating Depression Scale (ZSDS) questionnaire and analyzed using the Spearman correlation test. The results of the analysis of the level of disability and duration of suffering with depression both obtained p values <0.05 which means there is a relationship between the level of disability and duration of suffering with depression sufferers and former leprosy sufferers. Depression is influenced by many factors including education, gender, marital status, support, income, and the characteristics of the disease itself. Increased resistance to depression through self-efficacy is needed to increase the confidence of sufferers and former sufferers in overcoming their problems.
Hubungan Sumber Informasi Dengan Keputusan Ibu Menyusui Memilih Kontrasepsi Mal di Desa Aek Nabara Kabupaten Padang Lawas Tahun 2018
Authors: Kadir Dalimawaty
Published: December 2019

Pengetahuan yang rendah tentang kontrasepsi menyebabkan PUStakut menggunakan alat kontrasepsi atau menunjukkan sikap yang negatif terhadap kontrasepsi. Salah satunya adalah tentang MAL.Alat kontrasepsi alami Metode Amenorhea Laktasi (MAL) sangat berpengaruh dengan minatÂ Â  ibu nifas untuk menyusui bayinya selama 6 bulan tanpa makanan tambahan apapun, serta diberikan secara berkala pada bayinya. Tujuan dalam penelitian ini adalah untuk mengetahui hubungan sumber informasi dengan keputusan ibu menyusui memilih kontrasepsi MAL di Desa Aek Nabara Kabupaten Padang Lawas.Penelitian ini menggunakan survei analitik dengan pendekatan Cross Sectional. Populasi berjumlah 38 orang, dengan teknik pengambilan sampel menggunakan total population sehingga sampel dalam penilitian ini sebanyak 38 orang. Hasil uji statistik diperoleh nilai p = 0,008 (< 0,05).dari penelitian ini menunjukkan ada hubungan sumber informasi dengan keputusan ibu menyusui memilih kontrasepsi MAL di Desa Aek Nabara Kabupaten Padang Lawas tahunÂ  2018. Hasil penelitian ini diharapkan dapat dijadikan sebagai sumber informasi bagi ibu menyusui yang menggunakan MAL dan menyadari betapa pentingnya menggunakan alat kontrasepsi dan keputusan memilih metode amenorhea lsktasi (MAL), supaya minat ibu-ibu lainÂ  menggunakan metode amenorhea laktasi (MAL) aksemakin meningkat.Â Low knowledge about contraception makes childbearing age couples afraid to use contraception or show a negative attitude toward contraception. One of them is about Lactation Amenorrhea Method (LAM). Natural contraceptives regarding the Lactation Amenorrhea Method is very influential with the interest of the postpartum to breastfeed her baby for 6 months without any additional food, and is given regularly to her baby. The purpose of this study was to determine the relationship of information sources with breastfeeding mothers decision to choose MAL contraceptive in Aek Nabara Village, Padang Lawas Regency. This research uses analytical survey with Cross Sectional approach. The population is 38 people, with sampling technique using total population so that the sample in this research is 38 people. Statistic test results obtained p value = 0.008 (<0.05). of this study indicates that there is a correlation between information sources with the decision of breastfeeding mother to choose MAL contraception in Aek Nabara Village Padang Lawas Regency 2018 Expected to be a source of information for breastfeeding mother using MAL how important to use contraception and decision to choose amenorhea method (MAL) as one of the contraceptives, so that the mother's interest to use lactation amenorrhea method (MAL) will increase.