bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effects of Galangin on a Mouse Model of Vitiligo Induced by Hydroquinone
Authors: Huo Shi‐Xia , Liu Xin‐Ming , Ge Chun‐Hui , Gao Li , Peng Xiao‐Ming , Zhao Ping‐Ping , Yan Ming
Published: May 2014

Galangin, the main active component of Alpinia officinarum Hance, was tested in a mouse model of vitiligo induced in C57BL/6 mice by the topical application of 2 mL of 2.5% hydroquinone daily to shaved areas (2 × 2 cm) of dorsal skin for 60 days. Thirty days after the final application of hydroquinone, galangin (0.425, and 4.25 mg/kg) was administered orally for 30 days. The hair colour darkened when it grew back after treatment, and histological analysis showed that the number of melanin‐containing hair follicles had increased after treatment with all doses of galangin groups and 8‐methoxypsoralen (8‐MOP, the positive control) compared with the untreated vitiligo group (p < 0.05). The number of skin basal layer melanocytes and melanin‐containing epidermal cells had also increased significantly with the application of 4.25 mg/kg of galangin. The concentration of tyrosinase (TYR) in serum was found to have increased, whereas the content of malondialdehyde and the activity of cholinesterase had decreased after treatment with all doses of galangin and 8‐MOP, compared with control (p < 0.05). The expression of TYR protein in treated areas of skin also increased with the application of 4.25 mg/kg galangin and 8‐MOP. In conclusion, the results showed that galangin was able to improve vitiligo induced by hydroquinone in mice, with the activity related to concentrations of TYR, expression of TYR protein, activity of malondialdehyde and content of cholinesterase. Galangin may therefore be a potential candidate for the treatment of vitiligo, subject to further investigation. Copyright © 2014 John Wiley & Sons, Ltd.
Use of Dynamic Occupancy Models to Assess the Response of Darters (Teleostei: Percidae) to Varying Hydrothermal Conditions in a Southeastern United States Tailwater
Authors: Shea C. P. , Bettoli P. W. , Potoka K. M. , Saylor C. F. , Shute P. W.
Published: May 2014

During the past 100 years, most large rivers in North America have been altered for flood control, hydropower, navigation or water supply development. Although these activities clearly provide important human services, their associated environmental disturbances can profoundly affect stream‐dwelling organisms. We used dynamic multi‐species occupancy models combined with a trait‐based approach to estimate the influence of site‐level and species‐level characteristics on patch dynamic rates for 15 darter species native to the Elk River, a large, flow‐regulated Tennessee River tributary in Tennessee and Alabama. Dynamic occupancy modelling results indicated that for every 2.5 °C increase in stream temperature, darters were 3.94 times more likely to colonize previously unoccupied stream reaches. Additionally, large‐bodied darter species were 3.72 times more likely to colonize stream reaches compared with small‐bodied species, but crevice‐spawning darter species were 5.24 times less likely to colonize previously unoccupied stream reaches. In contrast, darters were 2.21 times less likely to become locally extinct for every 2.5 °C increase in stream temperature, but high stream discharge conditions elevated the risk of local extinction. Lastly, the presence of populations in neighbouring upstream study reaches contributed to a lower risk of extinction, whereas the presence of populations in neighbouring downstream study reaches contributed to higher rates of colonization. Our study demonstrates the application of a trait‐based approach combined with a metapopulation framework to assess the patch dynamics of darters in a regulated river. Results from our study will provide a baseline for evaluating the ecological consequences of alternative dam operations. Copyright © 2014 John Wiley & Sons, Ltd.
Armour Layer Analysis of Local Scour around Bridge Abutments Under Ice Cover
Authors: Wu P. , Hirshfield F. , Sui J.
Published: May 2014

A set of experiments was conducted for the local scour around bridge abutments under ice cover in non‐uniform sediments. By taking into account of the grain size of the armour layer and ice cover roughness, the dimensionless maximum scour depth is analysed. With an increase in grain size of the armour layer, the dimensionless maximum scour depth decreases. With the increase in ice cover roughness, the dimensionless maximum scour depth increases correspondingly. By using dimensional analysis, a regression relationship supports this conclusion. The conclusions drawn from this study provide crucial evidence for the protection of bridge foundations in winter time. Copyright © 2014 John Wiley & Sons, Ltd.
Status and Trends in Biotic Integrity in a Sub‐Tropical River Drainage: Analysis of the Fish Assemblage Over a Three Decade Period
Authors: Moncayo‐Estrada R. , Lyons J. , Ramirez‐Herrejon J. P. , Escalera‐Gallardo C. , Campos‐Campos O.
Published: May 2014

We characterized the biotic integrity of the sub‐tropical Duero River, Mexico, comparing current and past index of biotic integrity (IBI) scores with results of an environmental quality index (EQI), inventorying abiotic characteristics and human impacts, and documenting ecosystem changes over the last three decades. We sampled the fish community and measured environmental variables during the dry season of 2009 at 19 sites. We compared 2009 findings with fish data obtained in 1986 and 1991 at nine of the sites. The correlation between the IBI and EQI was high (r2 = 0.79, p = 0.0002), indicating that the IBI accurately characterized environmental condition. Thirteen sites were degraded (68%) based on IBI scores, three were fair (16%) and three had good conditions (16%). Based on the EQI, 12 sites were classified as poor (63%), two as fair (11%) and five as good (19%). A cluster analysis of nine abiotic variables and the IBI values yielded three groups: six sites with good integrity and environmental quality, eight with high chemical oxygen demand and four with high total dissolved solids. A discriminant analysis (square canonical correlation: 0.922, and Wilks' lambda significance: 0.001) identified biochemical oxygen demand, distance to vegetation and total dissolved solids as the main predictors. Compared to 1986 and 1991, 2009 IBI values and ratings had declined significantly (multiple response permutation procedure A = 0.16, p = 0.0005), indicating a trend of environmental deterioration, with scores and ratings at 7 of 9 sites lower in 2009. One site had declined from good to fair, one from good to poor, five from fair to poor, one had remained fair and one had remained good. Degradation was related to excessive human water use, reduced river flows, increased wastewater discharge, deforestation, erosion, and invasive species, and mismanagement of preserved sites (springs), all of which highlight an urgent need to reverse declining environmental conditions. Copyright © 2014 John Wiley & Sons, Ltd.
Enhanced spread Aloha physical layer design and performance
Authors: De Gaudenzi Riccardo , del Rio Herrero Oscar , Gallinaro Gennaro
Published: May 2014

This paper describes the key design and performance aspects of the Enhanced Spread Spectrum Aloha (E‐SSA) physical layer, which represents an essential component of the S‐band Mobile Interactive Multimedia European Telecommunication Institute standard. Thanks to advanced signal processing at the gateway side, the E‐SSA random access protocol allows to achieve unprecedented spectral efficiency in a pure asynchronous random access mode with high robustness against received packets power unbalance. The E‐SSA physical layer is closely derived from the Third Generation Partnership Wideband Code Division Multiple Access random access channel physical layer with some adaptation to best operate in the Land Mobile Satellite channels. Particular emphasis is devoted to the E‐SSA physical layer system design drivers as well to the packet transmission control policies, which are of high relevance for S‐band Mobile Interactive Multimedia. The demodulator architectural design is also illustrated jointly with some of the key detection performance. Finally, the E‐SSA random access protocol performance are reported for Additive White Gaussian Noise and satellite mobile channels. Copyright © 2014 John Wiley & Sons, Ltd.
Eigenfunctions of crack problems in the Mindlin plate theory
Authors: Bäcker D. , Kuna M. , Häusler C.
Published: May 2014

Based on the Mindlin plate theory the eigenfunctions for a through‐thickness crack in a bending and twisting plate have been derived. The results are given as power series in terms of deflection, rotation and stresses. By introducing two auxiliary functions in the Mindlin plate theory we obtained two decoupled partial differential equations of the fourth and second order. This system of partial differential equations allows for each crack face to describe all three types of static boundary conditions. The first eigenfunction of the stress state shows the same singular near‐tip field at the crack tip known from two‐ and three‐dimensional crack analyses as well as from Reissner's plate theory. The second eigenfunction similarly characterizes the constant stress parallel to the crack as the T‐stress in plane elastic problems.
Disclosure of Funding Sources and Conflicts of Interest in Phase III Surgical Trials: Survey of Ten General Surgery Journals
Authors: Bridoux Valérie , Moutel Grégoire , Schwarz Lilian , Michot Francis , Herve Christian , Tuech Jean‐Jacques
Published: May 2014

Background

Discussions regarding disclosure of funding sources and conflicts of interest (COI) in published peer‐reviewed journal articles are becoming increasingly more common and intense. The aim of the present study was to examine whether randomized controlled trials (RCTs) published in leading surgery journals report funding sources and COI.

Methods

All articles reporting randomized controlled phase III trials published January 2005 through December 2010 were chosen for review from ten international journals. We evaluated the number of disclosed funding sources and COI, and the factors associated with such disclosures.

Results

From a review of 657 RCT from the ten journals, we discovered that presence or absence of a funding source and COI was disclosed by 47 % (309) and 25.1 % (165), respectively. Most articles in “International Committee of Medical Journal Editors (ICMJE)‐affiliated journals” did not disclose COI. Disclosure of funding was associated with a journal impact factor >3 (51.7 vs 41.6 %; p < 0.01), statistician/epidemiologist involvement (64.2 vs 43.7 %; p < 0.001), publication after 2008 (52.9 vs 41.1 %; p < 0.01), and the journal being ICMJE‐affiliated (49.3 vs 40 %; p < 0.05). Conflict of interest disclosure was associated with publication after 2008 (38.7 vs 11.3 %; p < 0.001), and with the journal not being affiliated with ICMJE (36.9 vs 21.3 %; p < 0.001).

Conclusions

Of the published studies we investigated, over half did not disclose funding sources (i.e., whether or not there was a funding source), and almost three quarters did not disclose whether COI existed. Our findings suggest the need to adopt best current practices regarding disclosure of competing interests to fulfill responsibilities to readers and, ultimately, to patients.
Spectral Analysis and Euler Deconvolution Technique of Gravity Data to Decipher the Basement Depth in the Dehradun-Badrinath Area
Authors: Ghosh G. K. , Singh C. L.
Published: May 2014

The stratigraphic and tectonic setting in the northwest part of Himalayan belt is complex and thrusted due to the collision of Indian plate and the Eurasian plate. During the past, the Himalaya is divided into four parts; these are Outer Himalaya, Lesser Himalaya, Greater or Higher Himalaya and Tethys Himalaya. The appearance of basement rocks played a significant role in the Himalayan periphery for stratigraphic, structural and tectonic movement. The deformation pattern of the crustal rocks causing the rise of basement rocks which constitutes an integral part of crustal configuration during the evolutionary stages of the Himalaya. In this study, an attempt has been made to estimate the basement depth configuration using spectral analysis and Euler deconvolution technique of gravity data in the northwest Himalaya region. The elevation increases continuously from 500 m to 5100 m in SW to NE direction, however, Bouguer gravity anomaly decreases continuously from -130 mGal to -390 mGal in SW to NE direction due to the isostaic adjustment. Gravity anomaly is very low near Harsil, Badrinath and Joshimath area and observed higher elevation due to the deep rooted basement. However, there are extrusion of crystalline basement in and around the Badrinath area due to the resettlement of geologic process which are overlaid to the top surface of the sedimentary layers. Euler deconvolution technique has been applied to detect the direct basement depth and results show a good correlation with the average depth of the spectral analysis and other works carried by different authors. Three gravity profiles are selected in appropriate places orienting SW-NE direction with a profile length of 160 km, 150 km and 140 km respectively in the study area for calculating the average depth of the basement rock. The average basement depth calculated is around 11.27 km using the spectral analysis technique and results are well correlated with the results of various workers. Euler deconvolution studies along the three selected profiles have been interpreted. It has been observed that there are more number of cluster points falling between depth ranges of 10 to 15 km, dipping in SW to NE direction. Euler’s study shows deep rooted connection near Main Frontal Thrust (MFT), Main Boundary Thrust (MBT), Main Central Thrust (MCT), Bearing Thrust (BT) and Vaikrita Thrust (VT) locations as per profile study. Based on these studies three geological models have been prepared along the profiles showing different tectonic resettlement and depth of crystalline basement. Crystalline rocks exposed at the surface may be due to uplift along the shear in the MCT zone by kinetic flow basically, Munsiayari Thrust (MT) and VT in the of NW-Himalaya region.
Nine Years of GPS Measurements of Crustal Deformation at Imphal, Indo-Burmese Wedge
Authors: Singh Laishram Sunil , Gahalaut V. K. , Kumar Arun
Published: May 2014

We report results of 9 years of GPS measurements of crustal deformation at Imphal, Manipur, a site located in the Indo-Burmese wedge of northwest Sunda arc. The analysis of these measurements suggests that the site moves at a rate of about 36.3±0.5 mm/year towards N55º in the ITRF2008. With respect to the Indian plate it moves at a rate of 16.7 mm/year towards N222º, i.e., predominantly towards southwest. The site is located about 15 km east of the Churachandpur Mao fault (CMF), which is reported to accommodate part of the India-Sunda motion. The site motion is not significantly affected by the earthquakes that occurred in the nearby region. However, the 2004 Sumatra-Andaman earthquake caused a coseismic displacement of ∼ 3-5 mm predominantly towards southwest. The site motion is almost linear, with some seasonal variation, and does not show any evidence of accelerated slip or slow earthquake on the CMF or along the plate boundary.
Electrical Resistivity and Hydrochemical Indicators Distinguishing Chemical Characteristics of Subsurface Pollution at Cuddalore Coast, Tamil Nadu
Authors: Sonkamble Sahebrao
Published: May 2014

Electrical resistivity methods are applied extensively for shallow sub-surface objectives but it has constraints in distinguishing the chemical characteristics of the medium. However, this complexity can be resolved by integrated investigations where geophysical anomaly would be validated with hydro-geochemical data. The present study highlights the notable importance of integrated geophysical and hydrogeological investigations in demarcating sub-surface pollution due to saline water intrusion and industrial effluents at Cuddalore coast in India. Geophysical scanning encompassing a total of 35 vertical electrical sounding (VES) were validated with drilling lithologs, water level and water quality parameters from a network of 125 observation wells at a test site of 17 km2. To understand the spatial variation of sub-surface contamination, two profiles of apparent resistivity sections were generated covering VES points parallel to the coast. Results revealed that, the low order of resistivity range 3 to 10 Ω-m (up to 30-40 m depth) and total dissolved solids range 2000 to 10,000 mg/l of groundwater reflects sub-surface contamination but cannot distinguish kind of salinity which is further verified by chemical analysis of Ca2+ (1200-2041 mg/l), SO42− (3000-9480 mg/l) which confirms the gypsum pollution and Na+ (750-1000 mg/l), Cl− (1000-2000 mg/l) designate the marine water contamination. Further, static groundwater head measurements demarcate the study area into above mean sea level (MSL) and below MSL zones. This study has provided a rapid and comprehensive picture about spatial variations of groundwater contamination which can help in planning, protection and safe management of coastal aquifers in India and worldwide.
Ectomycorrhizal communities associated with silver fir seedlings (Abies alba Mill.) differ largely in mature silver fir stands and in Scots pine forecrops
Authors: Ważny Rafał
Published: May 2014

Context

The requirement for rebuilding forecrop stands besides replacement of meadow vegetation with forest plants and formation of soil humus is the presence of a compatible ectomycorrhizal (ECM) fungal community.

Aims

This study aims to assess ectomycorrhizal fungi diversity associated with silver fir (Abies alba Mill.) seedlings regenerating in silver fir stands and Scots pine forecrops.

Methods

One-year-old seedlings were sampled in six study sites: three mature fir forests and three pine forests. ECM fungi were identified by polymerase chain reaction amplification and sequencing of the internal transcribed spacer of rDNA.

Results

The mean mycorrhizal colonization exceeded 90 %. Thirty-six ectomycorrhizal taxa were identified in fir stands and 23 in pine forecrops; ten out of these species were common to both stands. The fungal communities were different between study sites (R = 0.1721, p = 0.0001). Tomentella stuposa was the only species present at all sites.

Conclusion

Silver fir seedlings in Scots pine forecrops supported smaller ECM fungal communities than communities identified in mature silver fir stands. Nevertheless, fungal colonization of seedling roots was similar in both cases. This suggests that pine stands afforested on formerly arable land bear enough ECM species to allow survival and growth of silver fir seedlings.
Outside the Inside: A Review of Soft-Tissue Abnormalities Seen on Thoracoabdominal Computed Tomography
Authors: Frank Susan J. , Friedman Shari , Flusberg Milana , Wolf Ellen L. , Stein Marjorie W.
Published: May 2014

In this review, we illustrate the computed tomographic features of thoracoabdominal soft-tissue abnormalities, which may be easily overlooked and often can provide important information regarding systemic processes. Examples include necrotizing fasciitis, heterotopic ossification, fat necrosis, benign and malignant neoplasms, endometriosis, and collagen vascular disease as well as systemic and congenital pathology.
Inhibitors of the Cdc34 acidic loop: A computational investigation integrating molecular dynamics, virtual screening and docking approaches
Authors: Arrigoni Alberto , Bertini Luca , De Gioia Luca , Papaleo Elena
Published: May 2014

Here, we carried out a computational study based on molecular dynamics, virtual screening and docking to identify potential inhibitory compounds of Cdc34, modulating the acidic loop conformation. The molecules identified in this study have been designed to act as molecular hinges that can bind the acidic loop in its closed conformation, thus inhibiting the Cdc34‐mediated ubiquitination cascade at the ubiquitin‐charging step. In particular, we proposed a pharmacophore model featuring two amino groups in the central part of the model and two lateral aromatic chains, which respectively establish electrostatic interactions with the acidic loop (Asp 108 and Glu 109) and a hydrogen bond with Ser 139, which is one of the key residues for Cdc34 activity.
Campylobacter jejuni gene cj0511 encodes a serine peptidase essential for colonisation
Authors: Karlyshev A.V. , Thacker G. , Jones M.A. , Clements M.O. , Wren B.W.
Published: May 2014

According to MEROPS peptidase database, Campylobacter species encode 64 predicted peptidases. However, proteolytic properties of only a few of these proteins have been confirmed experimentally. In this study we identified and characterised a Campylobacter jejuni gene cj0511 encoding a novel peptidase. The proteolytic activity associated with this enzyme was demonstrated in cell lysates. Moreover, enzymatic studies conducted with a purified protein confirmed a prediction of it being a serine peptidase. Furthermore, cj0511 mutant was found to be severely attenuated in chicken colonisation model, suggesting a role of the Cj0511 protein in infection.
Attenuating depletion using goal priming
Authors: Walsh Darlene
Published: May 2014

This research examines how goal priming can attenuate the depletion effect. Using different self‐control goals (i.e., savings and healthy eating) and different measures of self‐control ability (i.e., willingness to buy and actual consumption), this study reveals that when people were primed with cues related to a self‐control goal and then depleted, the effect of depletion on a subsequent self‐control task (related to the primed goal) became attenuated. Also, depleted people, relative to nondepleted people, reported a lower level of commitment to a self‐control goal; however, when cues related to a self‐control goal were primed, their level of goal commitment increased, weakening the depletion effect. This research clarifies questions related to the process underlying depletion, while highlighting the importance of goal commitment (a measure of motivation) in understanding depletion.
Transcriptional coexpression network reveals the involvement of varying stem cell features with different dysregulations in different gastric cancer subtypes
Authors: Kalamohan Kalaivani , Periasamy Jayaprakash , Bhaskar Rao Divya , Barnabas Georgina D. , Ponnaiyan Srigayatri , Ganesan Kumaresan
Published: May 2014

Despite the advancements in the cancer therapeutics, gastric cancer ranks as the second most common cancers with high global mortality rate. Integrative functional genomic investigation is a powerful approach to understand the major dysregulations and to identify the potential targets toward the development of targeted therapeutics for various cancers. Intestinal and diffuse type gastric tumors remain the major subtypes and the molecular determinants and drivers of these distinct subtypes remain unidentified. In this investigation, by exploring the network of gene coexpression association in gastric tumors, mRNA expressions of 20,318 genes across 200 gastric tumors were categorized into 21 modules. The genes and the hub genes of the modules show gastric cancer subtype specific expression. The expression patterns of the modules were correlated with intestinal and diffuse subtypes as well as with the differentiation status of gastric tumors. Among these, G1 module has been identified as a major driving force of diffuse type gastric tumors with the features of (i) enriched mesenchymal, mesenchymal stem cell like, and mesenchymal derived multiple lineages, (ii) elevated OCT1 mediated transcription, (iii) involvement of Notch activation, and (iv) reduced polycomb mediated epigenetic repression. G13 module has been identified as key factor in intestinal type gastric tumors and found to have the characteristic features of (i) involvement of embryonic stem cell like properties, (ii) Wnt, MYC and E2F mediated transcription programs, and (iii) involvement of polycomb mediated repression. Thus the differential transcription programs, differential epigenetic regulation and varying stem cell features involved in two major subtypes of gastric cancer were delineated by exploring the gene coexpression network. The identified subtype specific dysregulations could be optimally employed in developing subtype specific therapeutic targeting strategies for gastric cancer.
Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer
Authors: Abdel-Fatah Tarek M.A. , Russell Roslin , Albarakati Nada , Maloney David J. , Dorjsuren Dorjbal , Rueda Oscar M. , Moseley Paul , Mohan Vivek , Sun Hongmao , Abbotts Rachel , Mukherjee Abhik , Agarwal Devika , Illuzzi Jennifer L. , Jadhav Ajit , Simeonov Anton , Ball Graham , Chan Stephen , Caldas Carlos , Ellis Ian O. , Wilson David M. , Madhusudan Srinivasan
Published: May 2014

FEN1 has key roles in Okazaki fragment maturation during replication, long patch base excision repair, rescue of stalled replication forks, maintenance of telomere stability and apoptosis. FEN1 may be dysregulated in breast and ovarian cancers and have clinicopathological significance in patients. We comprehensively investigated FEN1 mRNA expression in multiple cohorts of breast cancer [training set (128), test set (249), external validation (1952)]. FEN1 protein expression was evaluated in 568 oestrogen receptor (ER) negative breast cancers, 894 ER positive breast cancers and 156 ovarian epithelial cancers. FEN1 mRNA overexpression was highly significantly associated with high grade (p = 4.89 × 10−57), high mitotic index (p = 5.25 × 10−28), pleomorphism (p = 6.31 × 10−19), ER negative (p = 9.02 × 10−35), PR negative (p = 9.24 × 10−24), triple negative phenotype (p = 6.67 × 10−21), PAM50.Her2 (p = 5.19 × 10−13), PAM50. Basal (p = 2.7 × 10−41), PAM50.LumB (p = 1.56 × 10−26), integrative molecular cluster 1 (intClust.1) (p = 7.47 × 10−12), intClust.5 (p = 4.05 × 10−12) and intClust. 10 (p = 7.59 × 10−38) breast cancers. FEN1 mRNA overexpression is associated with poor breast cancer specific survival in univariate (p = 4.4 × 10−16) and multivariate analysis (p = 9.19 × 10−7). At the protein level, in ER positive tumours, FEN1 overexpression remains significantly linked to high grade, high mitotic index and pleomorphism (ps < 0.01). In ER negative tumours, high FEN1 is significantly associated with pleomorphism, tumour type, lymphovascular invasion, triple negative phenotype, EGFR and HER2 expression (ps < 0.05). In ER positive as well as in ER negative tumours, FEN1 protein overexpression is associated with poor survival in univariate and multivariate analysis (ps < 0.01). In ovarian epithelial cancers, similarly, FEN1 overexpression is associated with high grade, high stage and poor survival (ps < 0.05). We conclude that FEN1 is a promising biomarker in breast and ovarian epithelial cancer.
A multiple profile approach to the palynological reconstruction of Norse landscapes in Greenland's Eastern Settlement
Authors: Ledger Paul M. , Edwards Kevin J. , Schofield J. Edward
Published: May 2014

Palynological research is increasingly revealing the landscape impacts of Norse colonisation in southern Greenland. Typically, although not exclusively, these studies are from depositional environments with highly localised pollen source areas close to fjord-side centres of medieval power. In contrast, this paper presents data from Vatnahverfi, an inland district of the Eastern Settlement, and explores the emergence of a cultural landscape through three pollen sequences at variable distances from Norse farms. Two are from mires with small pollen source areas close to (<100 m) and distant from (≥1500 m) probable farming activities. The other provides a more regional signal of vegetation change, albeit one located close to a Norse settlement.Landnámis marked primarily through an increase in microscopic charcoal and the appearance of pollen fromRumex acetosella, although significant differences between profiles are noted. Close to Norse ruins, pollen productivity from grassland communities increases and woodland and scrub representation declines. Further from archaeological remains, palynologically inferred human activity is primarily characterised by decreased productivity, notably declining influx from woodland and scrub species, reflecting grazing herbivores or coppicing. Abandonment of Vatnahverfi is indicated from the late 14th to early 15th century AD.
Sanctity and Pilgrimage in Medieval Southern Italy, 1000–1200
Authors: Oldfield Paul
Published: May 2014

Southern Italy's strategic location at the crossroads of the Mediterranean gave it a unique position as a frontier for the major religious faiths of the medieval world, where Latin Christian, Greek Christian and Muslim communities coexisted. In this study, the first to offer a comprehensive analysis of sanctity and pilgrimage in southern Italy between 1000 and 1200, Paul Oldfield presents a fascinating picture of a politically and culturally fragmented land which, as well as hosting its own important relics as important pilgrimage centres, was a transit point for pilgrims and commercial traffic. Drawing on a diverse range of sources from hagiographical material to calendars, martyrologies, charters and pilgrim travel guides, the book examines how sanctity functioned at this key cultural crossroads and, by integrating the analysis of sanctity with that of pilgrimage, offers important new insights into society, cross-cultural interaction and faith in the region and across the medieval world.
Iambic Poetics in the Roman Empire
Authors: Hawkins Tom
Published: May 2014

This is the first book to study the impact of invective poetics associated with early Greek iambic poetry on Roman imperial authors and audiences. It demonstrates how authors as varied as Ovid and Gregory Nazianzen wove recognizable elements of the iambic tradition (e.g. meter, motifs, or poetic biographies) into other literary forms (e.g. elegy, oratorical prose, anthologies of fables), and it shows that the humorous, scurrilous, efficacious aggression of Archilochus continued to facilitate negotiations of power and social relations long after Horace's Epodes. The eclectic approach encompasses Greek and Latin, prose and poetry, and exploratory interludes appended to each chapter help to open four centuries of later classical literature to wider debates about the function, propriety and value of the lowest and most debated poetic form from archaic Greece. Each chapter presents a unique variation on how these imperial authors became Archilochus – however briefly and to whatever end.
Secularism and Religion in Nineteenth-Century Germany
Authors: Weir Todd H.
Published: May 2014

Negotiating the boundaries of the secular and of the religious is a core aspect of modern experience. In mid-nineteenth-century Germany, secularism emerged to oppose church establishment, conservative orthodoxy, and national division between Catholics, Protestants, and Jews. Yet, as historian Todd H. Weir argues in this provocative book, early secularism was not the opposite of religion. It developed in the rationalist dissent of Free Religion and, even as secularism took more atheistic forms in Freethought and Monism, it was subject to the forces of the confessional system it sought to dismantle. Similar to its religious competitors, it elaborated a clear worldview, sustained social milieus, and was integrated into the political system. Secularism was, in many ways, Germany's fourth confession. While challenging assumptions about the causes and course of the Kulturkampf and modern antisemitism, this study casts new light on the history of popular science, radical politics, and social reform.
Performing Anti-Slavery
Authors: Cima Gay Gibson
Published: May 2014

In Performing Anti-Slavery, Gay Gibson Cima reimagines the connection between the self and the other within activist performance, providing fascinating new insights into women's nineteenth-century reform efforts, revising the history of abolition, and illuminating an affective repertoire that haunts both present-day theatrical stages and anti-trafficking organizations. Cima argues that black and white American women in the nineteenth-century abolitionist movement transformed mainstream performance practices into successful activism. In family circles, literary associations, religious gatherings, and transatlantic anti-slavery societies, women debated activist performance strategies across racial and religious differences: they staged abolitionist dialogues, recited anti-slavery poems, gave speeches, shared narratives, and published essays. Drawing on liberal religious traditions as well as the Eastern notion of transmigration, Elizabeth Chandler, Sarah Forten, Maria W. Stewart, Sarah Douglass, Lucretia Mott, Ellen Craft and others forged activist pathways that reverberate to this day.
Discussions on Climate and Cosmology
Authors: Croll James
Published: May 2014

The cause of the ice ages was a puzzle to nineteenth-century climatologists. One of the most popular theories was that the affected continents must somehow have been hugely elevated and, like mountains, iced over. However, in this 1885 study of the problem, James Croll (1821–90) argues that such staggering movement would have been impossible. Instead, he puts forward a new theory: that the eccentricity of the earth's orbit changes at regular intervals over long periods, creating 'great secular summers and winters'. Adopting a meticulous approach to the facts, he disproves a host of well-established notions across several disciplines and makes some remarkable deductions, including the effect of ocean currents on climate, the temperature of space, and even the age of the sun. With a focus on logical argument and explanation rather than mathematics, his book remains fascinating and accessible to students in the history of science.
Violence and the State in Languedoc, 1250–1400
Authors: Firnhaber-Baker Justine
Published: May 2014

Although it is often assumed that resurgent royal government eliminated so-called 'private warfare', the French judicial archives reveal nearly one hundred such wars waged in Languedoc and the Auvergne between the mid-thirteenth and the end of the fourteenth century. Royal administrators often intervened in these wars, but not always in order to suppress 'private violence' in favour of 'public justice'. They frequently recognised elites' own power and legitimate prerogatives, and elites were often fully complicit with royal intervention. Much of the engagement between royal officers and local elites came through informal processes of negotiation and settlement, rather than through the imposition of official justice. The expansion of royal authority was due as much to local cooperation as to conflict, a fact that ensured its survival during the fourteenth-century crises. This book thus provides a new narrative of the rise of the French state and a fresh perspective on aristocratic violence.
Direct numerical simulation of high-speed transition due to an isolated roughness element
Authors: Subbareddy Pramod K. , Bartkowicz Matthew D. , Candler Graham V.
Published: May 2014

We study the transition of a Mach 6 laminar boundary layer due to an isolated cylindrical roughness element using large-scale direct numerical simulations (DNS). Three flow conditions, corresponding to experiments conducted at the Purdue Mach 6 quiet wind tunnel are simulated. Solutions are obtained using a high-order, low-dissipation scheme for the convection terms in the Navier–Stokes equations. The lowest Reynolds number ($Re$) case is steady, whereas the two higher $Re$ cases break down to a quasi-turbulent state. Statistics from the highest $Re$ case show the presence of a wedge of fully developed turbulent flow towards the end of the domain. The simulations do not employ forcing of any kind, apart from the roughness element itself, and the results suggest a self-sustaining mechanism that causes the flow to transition at a sufficiently large Reynolds number. Statistics, including spectra, are compared with available experimental data. Visualizations of the flow explore the dominant and dynamically significant flow structures: the upstream shock system, the horseshoe vortices formed in the upstream separated boundary layer and the shear layer that separates from the top and sides of the cylindrical roughness element. Streamwise and spanwise planes of data were used to perform a dynamic mode decomposition (DMD) (Rowley et al., J. Fluid Mech., vol. 641, 2009, pp. 115–127; Schmid, J. Fluid Mech., vol. 656, 2010, pp. 5–28).
High Rayleigh number convection in a three-dimensional porous medium
Authors: Hewitt Duncan R. , Neufeld Jerome A. , Lister John R.
Published: May 2014

High-resolution numerical simulations of statistically steady convection in a three-dimensional porous medium are presented for Rayleigh numbers $Ra \leqslant 2 \times 10^4$. Measurements of the Nusselt number $Nu$ in the range $1750 \leqslant Ra \leqslant 2 \times 10^4$ are well fitted by a relationship of the form $Nu = \alpha _3 Ra + \beta _3$, for $\alpha _3 = 9.6 \times 10^{-3}$ and $\beta _3 = 4.6$. This fit indicates that the classical linear scaling $Nu \sim Ra$ is attained, and that $Nu$ is asymptotically approximately $40\, \%$ larger than in two dimensions. The dynamical flow structure in the range $1750 \leqslant Ra \leqslant 2\times 10^4$ is analysed, and the interior of the flow is found to be increasingly well described as $Ra \to \infty $ by a heat-exchanger model, which describes steady interleaving columnar flow with horizontal wavenumber $k$ and a linear background temperature field. Measurements of the interior wavenumber are approximately fitted by $k\sim Ra^{0.52 \pm 0.05}$, which is distinguishably stronger than the two-dimensional scaling of $k\sim Ra^{0.4}$.
A perceptually grounded model of the singular–plural distinction
Authors: WALLES HAYDEN , ROBINS ANTHONY , KNOTT ALISTAIR
Published: May 2014

abstract

Embodied theories of language posit that the human brain’s adaptations for language exploit pre-existing perceptual and motor mechanisms for interacting with the world. In this paper we propose an embodied account of the linguistic distinction between singular and plural, encoded in the system of grammatical number in many of the world’s languages. We introduce a neural network model of visual object classification and spatial attention, informed by a collection of findings in psychology and neuroscience. The classification component of the model computes the type associated with a visual stimulus without identifying the number of objects present. The distinction between singular and plural is made by a separate mechanism in the attentional system, which directs the classifier towards the local or global features of the stimulus. The classifier can directly deliver the semantics of uninflected concrete noun stems, while the attentional mechanism can directly deliver the semantics of singular and plural number features.
Colonial Debt, Resistance to U.S. Military Presence, Trustworthiness of Pro-U.S. Military Information Sources, and Support for the Military Buildup on Guam
Authors: Dalisay Francis
Published: May 2014

In this exploratory study, a representative community survey of 319 registered voters was conducted in the island of Guam to analyse the relationships between colonial debt (an internalised acceptance of colonisation), resistance to U.S. military presence, support for an impending U.S. military buildup in the island, and the perceived trustworthiness of information sources supportive of the buildup — that is, U.S. officials and the Pacific Daily News, a local newspaper. Results suggest that colonial debt was associated with less resistance to U.S. military presence, more support for the military buildup, and higher trustworthiness of two information sources supportive of the buildup. Resistance to U.S. military presence was linked with less support for the buildup and less trustworthiness of the two information sources. Implications and limitations are discussed.
KORÁNYI’S LEMMA FOR HOMOGENEOUS SIEGEL DOMAINS OF TYPE II. APPLICATIONS AND EXTENDED RESULTS
Authors: BÉKOLLÉ DAVID , ISHI HIDEYUKI , NANA CYRILLE
Published: May 2014

We show that the modulus of the Bergman kernel$\def \xmlpi #1{}\def \mathsfbi #1{\boldsymbol {\mathsf {#1}}}\let \le =\leqslant \let \leq =\leqslant \let \ge =\geqslant \let \geq =\geqslant \def \Pr {\mathit {Pr}}\def \Fr {\mathit {Fr}}\def \Rey {\mathit {Re}}B(z, \zeta )$of a general homogeneous Siegel domain of type II is ‘almost constant’ uniformly with respect to$z$when$\zeta $varies inside a Bergman ball. The control is expressed in terms of the Bergman distance. This result was proved by A. Korányi for symmetric Siegel domains of type II. Subsequently, R. R. Coifman and R. Rochberg used it to establish an atomic decomposition theorem and an interpolation theorem by functions in Bergman spaces$A^p$on these domains. The atomic decomposition theorem and the interpolation theorem are extended here to the general homogeneous case using the same tools. We further extend the range of exponents$p$via functional analysis using recent estimates.
Perturbed energy balance and hydration status in ultra-endurance runners during a 24 h ultra-marathon
Authors: Costa Ricardo J. S. , Gill Samantha K. , Hankey Joanne , Wright Alice , Marczak Slawomir
Published: May 2014

The present study aimed to assess the adequacy of energy, macronutrients and water intakes of ultra-endurance runners (UER) competing in a 24 h ultra-marathon (distance range: 122–208 km). Thead libitumfood and fluid intakes of the UER (n25) were recorded throughout the competition and analysed using dietary analysis software. Body mass (BM), urinary ketone presence, plasma osmolality (POsmol) and volume change were determined at pre- and post-competition time points. Data were analysed using appropriatettests, with significance set atP <0·05. The total energy intake and expenditure of the UER were 20 (sd12) and 55 (sd11) MJ, respectively (control (CON) (n17): 12 (sd1) and 14 (sd5) MJ, respectively). The protein, carbohydrate and fat intakes of the UER were 1·1 (sd0·4), 11·3 (sd7·0) and 1·5 (sd0·7) g/kg BM, respectively. The rate of carbohydrate intake during the competition was 37 (sd24) g/h. The total water intake of the UER was 9·1 (sd4·0) litres (CON: 2·1 (sd1·0) litres), while the rate of water intake was 378 (sd164) ml/h. Significant BM loss occurred at pre- to post-competition time points (P =0·001) in the UER (1·6 (sd2·0) %). No significant changes in POsmolvalues were observed at pre- (285 (sd11) mOsmol/kg) to post-competition (287 (sd10) mOsmol/kg) time points in the UER and were lower than those recorded in the CON group (P <0·05). However, plasma volume (PV) increased at post-competition time points in the UER (10·2 (sd9·7) %;P <0·001). Urinary ketones were evident in the post-competition samples of 90 % of the UER. Energy deficit was observed in all the UER, with only one UER achieving the benchmark recommendations for carbohydrate intake during endurance exercise. Despite the relatively low water intake rates recorded in the UER, hypohydration does not appear to be an issue, considering increases in PVvalues observed in the majority (80 %) of the UER. Population-specific dietary recommendations may be beneficial and warranted.
A genetic analysis of diapause in crosses of a southern and a northern strain of the cabbage beetle Colaphellus bowringi (Coleoptera: chrysomelidae)
Authors: Chen C. , Xiao L. , He H.M. , Xu J. , Xue F.S.
Published: May 2014

As a consequence of geographical variation in diapause mechanism in the cabbage beetle, Colaphellus bowringi, the southern strains enter diapause as an adult in response to long photoperiod, whereas the northern strains enter diapause in response to temperature. In the present study, we examined the inheritance of diapause by crossing a southern Xiushui strain (XS) with a most-northern Harbin strain (HB). The southern XS strain showed a clear short-day response for the induction of diapause, whereas the most-northern strain entered diapause regardless of photoperiod. Interestingly, the XS×HB progeny showed a short-day response, but the HB×XS progeny had no photoperiodic response, indicating that photoperiodic induction of diapause is influenced by maternal genotype. The incidence of diapause of F1 progeny was intermediate between their parents under short daylengths of 12 and 13 h. However, there was a sexual asymmetry, with the female parent exerting a greater effect on diapause incidence than the male parent, indicating a sex linkage in the inheritance of diapause induction. The χ2 test in C. bowringi revealed that the inheritance of diapause does not fit an additive hypothesis and also that the capacity for diapause is transmitted genetically (or possibly epigenetically) in a manner of incomplete dominance. These results suggest that a number of genetic factors are associated with differences in diapause capability in this beetle.
Duplicative or Complementary? The Relationship between Policy Consulting and Internal Policy Analysis in Canadian Government
Authors: Howlett Michael , Migone Andrea , Tan Seck L.
Published: May 2014

Policy consultants are external analysts who provide paid policy-related advice to governments on a contractual basis. Previous research on policy work has examined the work done within governments and by policy consultants separately but has not systematically compared and contrasted the two. A key question regarding the nature of policy advisory practices and policy advice systems in general, however, is whether consultants are duplicating the work of government officials in order to help “triangulate” internal advice or whether there is more of a complementary approach in which consultants supplement the work of internal analysts. This article explores the differences among the two groups using data collected over the past five years in two sets of surveys into internal and external policy work in Canada. The analysis finds a “complementary” relationship to exist, contrary to the conventional wisdom that outside or external advice is sought mainly in order to avoid biases in internal advice.
Let's Go to the Moon: Science Fiction in the North Korean Children's MagazineAdong Munhak, 1956–1965
Authors: Zur Dafna
Published: May 2014

Science fiction narratives appeared in the North Korean children's magazineAdong munhakbetween 1956 and 1965, and they bear witness to the significant Soviet influence in this formative period of the DPRK. Moving beyond questions of authenticity and imitation, however, this article locates the science fiction narrative within North Korean discourses on children's literature preoccupied with the role of fiction as both a reflection of the real and a projection of the imminent, utopian future. Through a close reading of science fiction narratives from this period, this article underscores the way in which science, technology, and the environment are implicated in North Korean political discourses of development, and points to the way in which these works resolve the inherent tension between the desirable and seemingly contradictory qualities of the ideal scientist—obedient servant of the collective and indefatigable questioner—to establish the child-scientist as the new protagonist of the DPRK.