Incidence, management and outcomes in hepatic artery complications after paediatric liver transplantation: protocol of the retrospective, international, multicentre HEPATIC Registry
Authors: Li Weihao , van der Doef Hubert P J , Wildhaber Barbara E , Marra Paolo , Bravi Michela , Pinelli Domenico , Minetto Julia , Dip Marcelo , Sierre Sergio , de Santibañes Martin , Ardiles Victoria , Uno Jimmy Walker , Hardikar Winita , Bates Sue , Goh Lynette , Aldrian Denise , Seisenbacher Jonathan , Vogel Georg F , Neto Joao Seda , Antunes da Fonseca Eduardo , Magalhães Costa Carolina , Ferreira Cristina T , Nader Luiza S , Farina Marco A , Dajani Khaled Z , Parente Alessandro , Bigam David L , Liang Ting-Bo , Bai Xueli , Zhang Wei , Gonsorčíková Lucie , Froněk Jiří , Bohuš Šimon , Franchi-Abella Stéphanie , Gonzales Emmanuel , Guérin Florent , Junge Norman , Baumann Ulrich , Richter Nicolas , Hartleif Steffen , Sturm Ekkehard , Rajakannu Muthukumarassamy , Palaniappan Kumar , Rela Mohamed , Pawaria Arti , Rajakrishnan Haritha , Surendran Sudhindran , Kumar Mukesh , Agarwal Shaleen , Gupta Subhash , Asthana Sonal , Bandewar Vaishnavi , Raichurkar Karthik , Spada Marco , Monti Lidia , Alterio Tommaso , Yanagi Yusuke , Uchida Hajime , Komine Ryuji , Evans Helen , Carr-Boyd Peter , Duncan David , Stefanowicz Marek , Latka-Grot Julita , Kolesnik Adam , Broering Dieter C , Raptis Dimitri A , Ann H Marquez Kris , Mali Vidyadhar , Aw Marion , Beretta Marisa , Van der Schyff Francisca , Quintero-Bernabeu Jesús , Mercadal-Hally Maria , Larrarte K Mauricio , Andres Ane M , Hernandez-Oliveros Francisco , Frauca Esteban , Casswall Thomas , Jorns Carl , Delle Martin , Gupte Girish , Sharif Khalid , McGuirk Simon , Superina Riccardo , Caicedo Juan Carlos , Jaramillo Catalina , Bitterfeld Leandra , Kastenberg Zachary , Shah Amit A , Domenick Bryanna , Acord Michael R , Mazariegos George V , Soltys Kyle , DiNorcia Joseph , Antala Swanti , Florman Sander S , Buchholz Bettina M , Herden Uta , Fischer Lutz , Dierckx Rudi A J O , Hartog Hermien , Bokkers Reinoud P H 
Published: June 2024

Introduction

Hepatic artery complications (HACs), such as a thrombosis or stenosis, are serious causes of morbidity and mortality after paediatric liver transplantation (LT). This study will investigate the incidence, current management practices and outcomes in paediatric patients with HAC after LT, including early and late complications.

Methods and analysis

The HEPatic Artery stenosis and Thrombosis after liver transplantation In Children (HEPATIC) Registry is an international, retrospective, multicentre, observational study. Any paediatric patient diagnosed with HAC and treated for HAC (at age <18 years) after paediatric LT within a 20-year time period will be included. The primary outcomes are graft and patient survivals. The secondary outcomes are technical success of the intervention, primary and secondary patency after HAC intervention, intraprocedural and postprocedural complications, description of current management practices, and incidence of HAC.

Ethics and dissemination

All participating sites will obtain local ethical approval and (waiver of) informed consent following the regulations on the conduct of observational clinical studies. The results will be disseminated through scientific presentations at conferences and through publication in peer-reviewed journals.

Trial registration number

The HEPATIC registry is registered at the ClinicalTrials.gov website; Registry Identifier:NCT05818644.