bluuebunny/crossref_metadata_2025 huggingface dataset:
The effects of laminectomy surgery on pain, functional disability, sensitization and active trigger points in subjects with lumbar disc herniation
Authors: Ezzati K. , Rehanian Z. , Yousefzadeh-Chabok Sh. , Ghadarjani Sh. , Davoudi-Kiakalayeh A.
Published: July 2023

Objectives. To evaluate the effects of laminectomy surgery on pain, functional disability, sensitization and active trigger points in subjects with lumbar disc herniation.

Methods. This study was a prospective pre‑post single group study. Seventy‑one patients (42 male and 29 female) have been enrolled in the research with an age range of 20–60 (48 ± 13.41). During 48 hours before surgery, patients were examined by a physiotherapist. Pain intensity were measured by visual analogue scale, disability by oswestry index (Persian version) and sensitivity level using pressure algometer. Three month after laminectomy, the patients were re‑examined for mentioned outcomes again.

Results. The majority of the patients (23 cases, 32.4 %) revealed 3 active trigger points of the muscles before surgery. 60 subjects (84.5 %) experienced a gradual onset of leg pain without a trauma history. Lumbar multifidus (74.9 %), medial gastrocnemius (73.2 %), soleus (70.4) gluteus medius (62 %) were the most involved muscles with trigger points before laminectomy. On the other hand, after laminectomy medial gastrocnemius (54.9 %), lateral gastrocnemius (53.5 %), soleus (50.7 %), multifidus (39.4 %) and quadratus lumborum (39.4 %) were the most involved muscles with trigger points. The existence of trigger points in longissimus thoracis (p = 0.04), quadratus lumborum (p = 0.001), gluteus maximus (p = 0.04) and tibialis anterior (p = 0.02) were decreased significantly after laminectomy. Pain, disability and pain pressure threshold revealed significant differences before and after surgery.

Discussion. The pattern of active trigger points of muscles was different before and after surgery. Multifidus and gastrocnemius were the most prevalent muscles with myofascial pain syndrome before and after surgery respectively.

Conclusion. The present study revealed that pain, disability, number and prevalence of trigger points decreased after lumbar laminectomy. Nevertheless, pressure pain threshold of trigger points increased after surgery. The pattern of active trigger points of muscles was different before and after surgery. Multifidus and gastrocnemius were the most prevalent muscles with myofascial pain syndrome before and after surgery respectively. In fact, current results showed that active trigger points should be considered before and after laminectomy surgery
Circular multiple burr hole for surgical removal of an extra and intracranial meningioma (technical note)
Authors: Haiat N. P. , Pereira M. G. , Gonsalves D. G. , Pires Aguiar P. H. , Lopes B. M. , Estevão I. A. , Pacheco C. C. , Aguiar P. H.
Published: July 2023

Introduction. Intracranial meningiomas are the most common primary central nervous system tumors and are mostly benign, arising from the meninges surrounding the brain, nerves, and vessels. An obstacle to the surgical resection of meningiomas is the risk of injury to the superior sagittal sinus and the resulting compromise to the integrity of the venous drainage. This article describes a circular multiple trepanation technique, which can be used to safely perform resection of extracranial and intracranial meningiomas, aiming to reach the largest possible tumor area, since patient prognosis is directly proportional to tumor resection.

Surgical technique. The first step is to make a horseshoe incision, then drill burr holes, forming a circumference around the bone meningioma. The next step is to connect the orifices, incising the dura mater affected by the tumor along the periphery of the extracranial meningioma. Subsequently, the bone and the dura mater are elevated. Thus, the bone and dural part are separated from the intradural part, which is, in turn, removed later. Results. The circular multiple trepanation technique was performed and a gross total resection of the extracranial and intracranial meningioma (Simpson grade I) was achieved. The postoperative period showed positive results, with an improvement in the patient’s eye disorder and interruption of generalized tonic‑clonic seizures.

Conclusion. The circular multiple trepanation approach for treating extracranial and intracranial meningiomas described in this note is performed safely and effectively, with good patient prognosis. Although it is a recognized option, it has been insufficiently described, and it is therefore important to expand the knowledge and proper use of this technique among neurosurgeons.
ON THE PARABOLIC PARTITIONS OF A NUMBER
Authors: Vega F. Javier de
Published: July 2023

The paper solves the enumeration of the set of partitions of in which the nondecreasing sequence of parts , is contained in a degree-2 polynomial . This is a generalization of the partitions of a number into arithmetic progressions. We also study the problem of dividing into parts whose differences between consecutive parts are consecutive integers. In particular, we focus on the problem of the sum of consecutive triangular numbers.
http://jmsronline.com/archive-article/management-of-hyperglycemia-in-diabetics-with-cardiovascular-disease
Authors: MS Sridhar
Published: July 2023

Purpose: To present a case of systemic sclerosis with asymmetrical skin involvement, decreased tear production not responding to topical cyclosporine therapy and corneal edema in one eye. Methods: An 84 years old female diagnosed with scleroderma two years ago presented with history of decreased vision in the left eye of 10 days duration. Results: She had generalised tight skin which was more on the left side. The skin of the face including the eyelids was tight. Her best corrected visual acuity was 20/30, N6 in the right eye and in the left eye, it was 20/200. The Schirmer’s test without anaesthesia revealed a value of 3 mm in the right eye and 1 mm in the left eye. Anterior segment evaluation showed clear cornea with no guttata in the right eye. In the left eye, there was stromal oedema involving inferior half of the cornea with superficial blood vessels inferiorly. Both the corneas showed central superficial punctuate keratopathy. Anterior segment optical coherence tomography showed normal cornea in the right eye, whereas in the left eye there was hyper-reflectivity at the level of Descemet’s membrane suggestive of increased fibrosis and the corneal thickness was more. Conclusions: Systemic sclerosis can present with asymmetrical skin involvement, decreased tear production not responding to topical cyclosporine therapy and corneal edema in one eye. Further studies are warranted to develop treatment strategies of managing corneal edema in systemic sclerosis. Keywords: systemic sclerosis (SSc); scleroderma; secondary Sjogren’s syndrome; corneal oedema; anterior segment optical coherence tomography
“Mountains” on the Draft of the Land of Fort Narym by S.U. Remezov
Authors: Barsukov E. V. , Chernaya M. P.
Published: July 2023

This article describes an unusual source—the “Draft of the Land of Fort Narym” from the “Sketchbook of Siberia” by Semen Remezov. This is a spatial-graphic model, rendering late 17th-century realities in a conventional schematic manner. It covers the Narymsky and Ketsky uyezds (currently, northern Tomsk Region, known as Narym Territory). The encoded information relates to the history, geography, ethnography, settlement, and infrastructure at this territory in the late 17th century. One of the features represents elevations. We discuss its accuracy and relevance to the history and culture of the Narym Territory, and outline the ways of solving related problems. To render elevations, the cartographer used two types of conventional signs: those actually representing mountains and ranges, and thick lines. We conclude that “mountains” on the draft refer to real geographic features of the Narym Territory, described by 17th–19th century travelers and scholars and by the local oral tradition, and supported by modern geographical records. S.U. Remezov represented elevated areas with reference to their practical meaning for Russian reclamation.
Color stability of composite materials to food colorants: A laboratory study
Authors: Glebova Daria A. , Permyakova Anastasia V. , Shashmurina Anna B. , Gladarevskaya Ekaterina I. , Shashmurina Victoria R. , Nikolayev Alexander I.
Published: July 2023

BACKGROUND: Maintaining the esthetic characteristics of direct composite restorations for a long time is relevant. The color stability of food colorants is an important esthetic characteristic of a composite material. Comparative information about the color stability of modern composite restorative materials and recommendations based on optimal clinical results for direct composite restoration are of interest.
AIM: To compare the color stability of modern composite restorative materials with the most common food colorants in laboratory conditions.
MATERIALS AND METHODS: The color stability of modern restorative materials, namely, Restavrin (Technodent, Russia), GrandioSO (VOCO, Germany), Harmonize (Kerr, USA), Charisma Classic (Kulzer, Germany), Filtek Z250 (3M, USA/Germany), and Estelite Asteria (Tokuyama, Japan), were assessed. Black coffee, black tea, carbonated soft drink cola, dry red wine, and cognac were used as coloring solutions. The samples were exposed for 14 days, and the temperature was 37 C. The control solution was distilled water. Vita Easyshade Advance 4.0 spectrophotometer was used. The average deviation of the color of the studied samples from the reference indicators (∆E), total color stability of the studied materials ( ∆Em), and coloring potential of different coloring solutions in relation to composite materials ( ∆Ec) were determined.
RESULTS: The deviation of the color of the studied samples of composite materials from the reference indicators (∆Е) depending on the coloring solution was assessed. The total color stability of the studied materials in relation to food colorants ( ∆Em) as this characteristic deteriorates was as follows: Estelite Asteria, 8.640.08; Harmonize, 10.300.14; Restavrin, 12.300.12; GrandioSO, 12.960.10; Charisma Classic, 13.940.14; and Filtek Z250,15.820.15. The most aggressive food colorants with respect to composite restorative materials were black coffee ( ∆Ec=20.080.12), dry red wine ( ∆Ec=19.180.10), and black tea ( ∆Ec=18.54 0.15).
CONCLUSION: Information about the color stability of composite materials in relation to food colorants allows planning the restoration of teeth located in an esthetically significant area, taking into account the eating habits of patients.
Biological profile of the follicular fluid. A pilot study
Authors: Bespalova Olesya N. , Shengelia Margarita O. , Zagaynova Valeriya A. , Chepanov Sergey V. , Komarova Evgeniia M. , Kogan Igor Yu.
Published: July 2023

BACKGROUND: One of the most important research areas in the field of reproductive medicine is the search for biochemical and immunological parameters of oocyte quality and predicting the effectiveness of assisted reproductive technology protocols.
AIM: The aim of this study was to evaluate the expression of follicular fluid soluble human leukocyte antigen-G, human leukocyte antigen-E, human leukocyte antigen-C, progesterone-inducing blocking factor, and relaxin levels in women with reproductive disorders.
MATERIALS AND METHODS: This prospective cohort study included 22 patients undergoing infertility treatment in a superovulation stimulation protocol using gonadotropin-releasing hormone antagonists. The inclusion criteria were age from 25 to 39 years, tubal-peritoneal factor infertility, and voluntary participation informed consent. The levels of soluble human leukocyte antigen-G, human leukocyte antigen-E, human leukocyte antigen-C, progesterone-inducing blocking factor, and relaxin in follicular fluid samples were determined on the day of transvaginal follicle puncture by enzyme immunoassay.
RESULTS: We established an inverse correlation between the expression levels of progesterone-inducing blocking factor and relaxin (r = 0.450) in the follicular fluid, antibodies to thyroperoxidase (r = 0.649), and thyroid-stimulating hormone (r = 0.519). We also found a direct correlation between human leukocyte antigen-E parameters in the follicular fluid, age (r = 0.813) and Body Mass Index (r = 0.866), as well as between human leukocyte antigen-C expression levels and total testosterone (r = 0.960). No data were obtained on any significant correlations between the studied biomarkers and the number of received oocytes.
CONCLUSIONS: In this comprehensive study, we were the first who found the expression levels of five different follicular fluid components, namely, soluble human leukocyte antigen-G, human leukocyte antigen-E, human leukocyte antigen-C, progesterone-inducing blocking factor, and relaxin. Such a complex assessment of the follicular fluid can allow for establishing the quality of the oocyte to predict the onset of pregnancy in an in vitro fertilization protocol.
Premature rupture of membranes: the current state of the problem and approaches to the rational tactics of labor management
Authors: Morozova Maria A. , Bezhenar Vitaly F.
Published: July 2023

Premature rupture of membranes occurs in 220% of all pregnancies. The possibility of identifying risk factors and pre dicting this complication are of great interest in practical obstetrics. This review article highlights the current state of the problem and presents approaches to the rational tactics of labor management in case of premature rupture of membranes. We also present the algorithms for the management of labor in the Obstetrics and Gynecology Clinic, Academician I.P. Pavlov First Saint Petersburg State Medical University.
The history of the Journal of Obstetrics and Women’s Diseases (to the 135th anniversary of the first issue and the 25th anniversary of the revived edition)
Authors: Aylamazyan Eduard K. , Kira Evgeny F. , Rodin Igor G.
Published: July 2023

This article is dedicated to the 25th anniversary of modern history and the 135th anniversary of the first domestic publication of the Journal of Obstetrics and Womens Diseases. The article traces the history of the Journal, its development and state of the art, while reflecting amazing facts, sometimes filled with drama. The Journal of Obstetrics and Womens Diseases has become a prominent publication, thanks to which practitioners, even in the remotest corners of Russia, can be aware of advanced medical technologies and important scientific events, and acquainted with the latest achievements in the field of obstetrics and gynecology, as is evidenced by leading articles published in the Journal.
Uridine increases endurance and improves the rehabilitation of experimental animals after physical performance
Authors: Krylova Irina B. , Selina Elena N.
Published: July 2023

BACKGROUND: The pharmacological correction of metabolic processes, providing an increase in the efficiency and duration of physical performance and contributing to rapid rehabilitation, is an important component of the regulation of adaptation. Previously, we found that the pyrimidine nucleoside uridine exhibits antihypoxic properties, activates mitochondrial K+ATP channels (mitoKATP), normalizes energy metabolism, reduces lipid peroxidation, activates the antioxidant system, and increases glycogen content. The substance with such properties was assumed to increase endurance and improve recovery after physical performance.
AIM: To examine the effect of uridine on the endurance of experimental animals in the forced swimming test under different intensities of physical performance and their rehabilitation.
MATERIALS AND METHODS: Experiments were performed on male Wistar rats (350380 g) and male outbred mice (2530 g). In the first series, the effect of uridine on the rats endurance was studied in the forced swimming test with a load of 5%, 7%, or 10% of the animal weight. In the second series, the effect of uridine on the first phase of recovery was evaluated in a three-load swimming test. Mice with 10% load were subjected to a swimming test three times, after which the trail index the ratio of time of the third trail to the first trail was determined. The frequency of animals with low, medium, and high recovery ability was estimated. Uridine 30 mg/kg or physiological saline (control) was administered 30 min before testing, 5-hydroxidecanoate (5-HD, mitoKATP blocker) 5 mg/kg 45 min before testing, and mexidol (reference drug) 200 mg/kg 50 min before testing.
RESULTS: Uridine increased the critical swimming duration by 58% and 44% at 5% and 7% exercise, respectively, in comparison with control. At 7% load, the drug increased the period before the appearance of the first signs of fatigue by 100%. After the blockade of mitoKATP channels, the effect of uridine decreased by 40% in the presence of fatigue and 24% in critical swimming duration. In the three-load swimming test, uridine increased the trail index by 1.5 times, which was comparable to the effect of mexidol, and increased the number of animals with a high ability to recover by 2.6 times. The use of uridine after mitoKATP channel blockade did not lead to a decrease of its positive effect and the blockade of channels with 5-HD did not affect rehabilitation.
CONCLUSIONS: Uridine increases the endurance of rats with a medium load in the forced swimming test and the rehabilitation of mice in the three-load swimming test. It also increases the number of animals with a high ability to recover after a swimming performance. The mechanism of its effects was realized both through the activation of mitoKATP channels and, probably, the stimulation of glycogenesis.
Effect of synthetic folic acid surplus on neurological symptoms in offspring
Authors: Kachanov Dmitriy A. , Tikchonova Aleksandra A. , Orlova Veronika S. , Dzhanbekova Karina  R. , Fedotova Milena S. , Karabanova Anna V.
Published: July 2023

BACKGROUND: Folic acid is crucial for vital activities in both macro- and microorganisms. It is necessary for methylation, nucleotide synthesis, methionine formation, and reduction of the toxic effects of homocysteine. The addition of synthetic folic acid to the diet of pregnant women and those at pre-pregnancy preparation significantly reduced the risks of fetal neural tube defects, heart defects, and defects in other organs and systems. Folic acid can also help improve fertility potential. However, adverse effects of folic acid proficite on the health of older adults (asymptomatic B12-deficient status) and offspring of mothers taking high doses prescribed by medical specialists were reported, such as risks of infectious, inflammatory, and allergic diseases of the upper respiratory tract in children, eczema, psychomotor developmental disorders, and insulin resistance. In 1980, the direct excitatory effect of folic acid on synaptic transmission in the central nervous system was confirmed. This is due to the molecular structure because it contains L-glutamate.
AIM: To prove the correlation among probable neuropathologies, including a reduced threshold of seizures, a high risk of epilepsy in a model of offspring of Wistar rats with high-dose folate throughout gestation, and pre-pregnancy preparation.
MATERIALS AND METHODS: Experiments on Wistar rats (n = 45) were conducted to determine the occurrence of the first convulsive event by introducing 20% caffeine solution at the rate of 100 mg/kg of weight intraperitoneally.
RESULTS: In the control group, the average clonus time was 1779.6 s; in the experimental group with a 1 mg/kg folic acid per diet dosage, it was 797.3 s; and in the second group with a 5 mg/kg folic acid per diet, it was 439.7 s (p 0.01).
CONCLUSION: The difference in the convulsive threshold may be due to changes in synaptic density following excess levels of synthetic folic acid during neural tube formation and subsequently during the differentiation of nervous tissue in the central nervous system (particularly, in the third trimester with a massive appearance of glutamatergic receptors), which can affect neurogenesis and neural network formation.
Evaluation to prevent influenza Evaluation of Control Measure Against Influenza Epidemic by Multiagent Simulation
Authors: Iwanaga Saori
Published: July 2023

Background: At the campus of Japan Coast Academy in January 2017, 37 of 150 students developed influenza (situation A). Besides, 18 of 56 students at the training ship and 13 of 109 students at the campus of the academy developed influenza in January 2019 at same time (situation B and C). The rare data of the three situations including behavioral history data of students, daily clinical data of influenza-positive students and social contact data of students were collected and directly analyzed. Then, using a proposed spatio-temporal Susceptible – Exposed – Pre-infectious – Infectious – Recovered (SEPIR) model, the incubation period and the infectivity rate from asymptomatic people were calculated. And multiagent simulation (MAS) of influenza epidemic has been performed using spatio-temporal SEPIR model and has been validated. Aim: Effective non-pharmaceutical interventions to prevent influenza epidemic is described. Methods: The epidemic is defined using ratio of daily patients in the community. Then, situation A and B are classified as epidemics, but situation C is not. Using the validated MAS, three measures of infection control (preventive measure such as wearing mask, school closure when 20 % of patients are discovered and that when first patients are discovered) against influenza in the two epidemic situations A and B are evaluated. The criteria for evaluation are the frequency of epidemic and the ratio of total patients. Results: The frequency of epidemic by the school closures as infection control measure is 100 %, whereas, those by the preventive measure are low (4.5 % and 22.9 %) in two epidemic situations. The ratio of total patients by the school closures are above 80 % and those by the preventive measure are low (7.6 % and 23.0 %) in two epidemic situations. Conclusions: MAS suggests that the preventive measure such as wearing masks, washing hands and better ventilating rooms is useful. Then, the preventive measure is recommended after winter vacation or three-day weekend in January not school closure.
Case Report of a Relapse of Mantle Cell Lymphoma on Patient with Chronic Infection with Covid-19
Authors: Bendari Mounia , Elbouzidi Abderrahmane , Ahnach Mariam , Benchekroun Said
Published: July 2023

Background: Mantle cell lymphoma (MCL) is a distinct subtype of Non-Hodgkin Lymphoma (NHL), it affects 5 to 8% of NHL, it is a clinically heterogeneous disease occurring within a heterogeneous patient population. The median age at time of diagnosis is over 65 years old. The incidence increased with age, and also affects man more than women with ratio of 3 to 1. Overall survivor is different according to subtype of lymphoma. Most patients present at advanced stage, and 30% present in leukemic phase. Case report: We report a case of 60-year-old women with relapsed mantle cell lymphoma. The patient had no medical past history. The diagnosis of mantle cell lymphoma was made in 2019 revealed by anemic syndrome, the morphological and histological study of lymph node and bone marrow biopsy confirmed the mantle cell lymphoma with expression of CD19+, CD20+, CD5+, CD23-, Cyclin D1+, and KI 67 at 60%. The PET Scan showed FDG-avid disease, the laboratory studies remarques for high level of LDH, elevated B2 microglobulin. The patient underwent R-DHAP regimen (Rituximab, Aracytine, Cisplatin, prednisone) and achieved complete remission after 2 curses, the PET Scan was negative, and the bone marrow biopsy was normal, the collect of hematopoietic stem cell was performed, and the patients received 2 other courses of RDHAP regimen. She does not benefit from autologous hematopoietic stem cell transplant (HSCT) because of severe infection of COVID19. In reality, patient had a server pneumoniae with chronic fever, she was admitted for intravenous antibiotics, all biological exam showed a high level of C- reactive protein, and high level of d-dimers, but no sign of relapse was found. The patient still febrile during 6 months. Autologous hematopoietic stem cell transplant was not realized, but she received maintenance treatment with Rituximab. One year later, the patient developed a mass under the knee with deep deterioration of general condition, relapse was suspected, the surgical biopsy was performed and histological study confirmed the relapse of mantle cell lymphoma. The aim of this case report is to describe the difficulties to manage mantle cell lymphoma associated to covid 19 infection and report the consequences of therapeutic decision. Conclusion: Not all mantle cell lymphoma is the same, it is crucial to identify patients appropriate for aggressive treatment, autologous hematopoietic stem cell transplant improves event free survival with unclear benefit in all patients, maintenance Rituximab improves overall survivor. Minimal residual disease may guide future therapeutic decisions and help physicians manage these patients. Our patient does not receive autologous hematopoietic stem cell transplant and suffers from chronic Covid19 infection. This association is complicated for the physician and the difficulties of access to targeted therapy in our country limits the therapeutic proposals for patients in relapse.
Reversal of Direct Oral Anticoagulants: Meeting a Need & Filling a Gap
Authors: Lindhoff-Last Edelgard , Ansell Jack
Published: July 2023

Presently, three reversal strategies are available to reverse the anticoagulant activity of the direct oral anticoagulants, each with various limitations or drawbacks. A new reversal agent that addresses some of these limitations or gaps in therapy is in advanced clinical trials. Ciraparantag is a small molecule specifically designed to bind non-covalently by charge-charge interaction to unfractionated heparin and low molecular weight heparin. It shows similar binding characteristics to the direct oral anticoagulants with no off-target binding of selected proteins or commonly used drugs demonstrated to date. Ciraparantag reaches maximum concentration within minutes following intravenous administration with a half-life of 12 – 19 minutes. It is primarily hydrolyzed by serum peptidases into two metabolites, neither of which has substantial activity. Ciraparantag and its metabolites are recovered almost entirely in the urine. In animal models of bleeding a single intravenous dose of ciraparantag given at peak concentrations of an anticoagulant significantly reduces blood loss. In Phase 1/2 clinical trials, ciraparantag restores coagulation in direct oral anticoagulant-treated healthy volunteers with in minutes with a sustained effect over 24 hours. The drug is well tolerated with minor side effects, the most common of which is a flush or sensation of warmth after administration. As a phase 3 trial is in preparation to clinically prove its effectiveness, ciraparantag appears to address many of the short-comings of current reversal strategies.
Large Variation in Diagnosis and Treatment of Chyle Leak after Pancreatic Surgery: A Nationwide Insight
Authors: Rietveld S.C.M , Latenstein A.E.J , Besselink M.G.H , Haverkamp J.A , Haver J.T.M
Published: July 2023

Background: In the current literature different diagnosis and treatment strategies for chyle leak after pancreatic surgery are described. In 2017, the International Study Group for Pancreatic Surgery defined a consensus-based definition for diagnosis. However, consensus on the optimal treatment strategy is lacking. Aim: The aim of this multicenter study is to investigate the current treatment and diagnosis of chyle leak after pancreatic surgery in clinical practice in the Netherlands to gain insight into practical applications of chyle leak. Methods: A nationwide survey about the diagnosis and treatment of chyle leak was sent to specialized dieticians and pancreatic surgeons from all 16 pancreatic centers collaborating in the Dutch Pancreatic Cancer Group. Data was quantitative processed according to thematic content analysis and by using descriptive analysis. Results: In total, 16 dieticians from 16 centers and 20 surgeons from 12 centers completed the questionnaire. Analysis showed that the International Study Group for Pancreatic Surgery-definition for chyle leak was used in clinical practice by 31% (n=11) of the respondents. The results show also large nationwide variation in treatment of chyle leak after pancreatic surgery, as well between as within centers. The most common treatment was a step-up approach of nutritional therapies (44% (n=16)), which starts with an enteral fat restricted diet enriched with medium chain fatty acids followed by total parenteral nutrition. Conclusion This study shows that the current diagnosis and treatment strategies for chyle leak after pancreatic surgery in clinical practice on a nationwide scale are different. More comparable studies are needed to define the optimal treatment strategy for chyle leak. There is need for an international multidisciplinary (sub)working group to reach consensus on the treatment strategy of chyle leak and to discuss implementation strategies for clinical practice.
Using Service-Learning Experiences to Improve Cultural Competence in Pre-Professional Dietetic Students
Authors: Huye Holly
Published: July 2023

Cultural encounters were used in a senior-level undergraduate nutrition capstone course to enhance students’ cultural competence attitudes and skills. The course included a service-learning component for which students met weekly with international students who were enrolled in an intensive English language program as conversation partners. The course content and structure focused on Campinha-Bacote’s cultural competence model. The model includes 5 constructs: cultural awareness, cultural knowledge, cultural skill, cultural encounters, and cultural desire. This capstone, writing-intensive course included creative writing activities, discussion, journaling, and reflection papers. The 20-item Inventory for Assessing the Process of Cultural Competence Among Healthcare Professionals-Student Version© was used as the pre-post-test measure. Paired sample t-tests were used to calculate outcomes. A significant increase from pre-test to post-test in the total score was found (t(18) = -6.852, p < 0.001). Pre- and post-test scores indicated students were operating at a culturally competent level. There were significant increases in all constructs with notable increases in cultural knowledge and cultural skill constructs. A course dedicated to developing pre-professional healthcare students’ cultural competence levels may better prepare them for professional practice.
Effect of Mobile-Based Application Usage on Time in Range and Time above Range in Patients with Diabetes Mellitus: A Pilot Cohort Retrospective Study
Authors: Akulova Mikhalina , Nesterova Anna , Isaacs Diana , Molodkin Eugene , Ushakov Mike
Published: July 2023

Achieving recommended glucose targets is challenging for many people with diabetes. An application that assists in self-management through continuous glucose monitoring may help reduce glycemic variability and help people with diabetes reach glucose targets. We aimed to evaluate how a digital collection of meal photos and postprandial continuous glucose monitoring data may impact glycemic stability. We assessed people with type 1 or type 2 diabetes and a time in range of <70%. Glucose parameters were measured at the beginning of application usage and after 14 days. To exclude time in range improvement due to continuous glucose monitoring use, the preceding glucose data of each user were collected in a control cohort. The intervention was via a photo-based food diary combined with continuous glucose monitoring data history. Users (n=21) demonstrated significant improvements in time in range (11.0%±5.0, P=.001) and time above range (-12.0%±5.0, P=.001). Combining continuous glucose monitoring data with meal photos in a mobile application could help improve time in range and time above range. A photo-based diabetes management application with visualized continuous glucose monitoring data and connection to specific meals allows better understanding of different meal-related decisions among individuals, thus decreasing fluctuations in glucose levels. Further research is needed to evaluate time in range and time above range changes caused by the regular use of the digital food diary combined with continuous glucose monitoring data.
Why have people with dementia problems with walking and balance?
Authors: Rakt Jan , Grunwald2 Steve
Published: July 2023

Introduction: The walking performance and the balance are elements that change by people with dementia even before the diagnosis -dementia – is established. The reason is still a mystery, still there are investigations that think on an increase of pathological neurological increasing tone -paratonia. Investigations of that tone-increase are done in the beginning of this disease but mostly in a sitting-relax- position. But then is often a slight or even no increase present, but to know the impact, the tone measurement should be measure when people are performed this activity. Method: To invest the impact of movements by people with dementia, we have taken the Rikli and Jones - Senior Fitness Test- by 35 participant with the diagnosis dementia. Further we did tests as the B.B.S., Tinetti, Statiek test and the tone measurement -Mas-P when walking or immediately after in stand or when stand was no option in sit. Results: All participants give a worse results on the elements, balance, speed and walking and scored almost equal with age equal persons without dementia on the other items. The other tests (B.B.S., Tinetti, Statiek test) were also lesser and all had a higher tone when this measurement was done immediately after the walking/balance performance and certainly when they are doing the performance. Conclusion: The impact of the pathological neurological tone (paratonia) was evident in this investigation of 35 people with dementia. The tone was the most important factor that interfered with the speed, walking and balance performance. But this asked for further investigation what walking and balance do with the tone of people with dementia. Further is it a question of an treatment as fall prevention on the way given now, has an effect or maybe has an negative influence on the balance performance. To get a better treatment than must the tone decrease, to get the possibilities of selectivity and speed possible and that is only possible in an gravity decreasing environment as par example water. That should be THE therapy that can slowdown the disease and stimulated the balance performance much longer than when the situation has to deal with gravity and thus an increase tone. Why have people with dementia problems with walking and balance? Authorship Credit: “Criteria authorship scientific article” has been used “Equal Contribution” (EC)
The Coupling between Epilepsy and Cortical Spreading Depression of Leão
Authors: Mayevsky Avraham
Published: July 2023

Objectives: The discovery of cortical spreading depression 80 years ago by Leão was intimately connected to epilepsy research. In our studies we found that monitoring of brain hemodynamics, metabolic ionic and electrical activities are very similar in the two pathophysiological events. Here we are presenting the coupling between epilepsy and cortical spreading depression while monitoring of mitochondrial nicotinamide adenine dinucleotide-NADH together with other physiological parameters in real time in vivo. Methods: Rats and Mongolian gerbils were used in three models of induction of epilepsy, namely injection of pentylenetetrazol-metrazol, exposure of the rats to hyperbaric oxygenation in a pressure chamber and using a strain of gerbils that are developing seizures spontaneously. We monitored brain oxygen levels, mitochondrial NADH, extracellular potassium levels, Direct Current-DC steady potential and electroencephalography-EEG in the very slightly anesthetized animals. Results: The results could be summarized as follows: 1. In almost all animal tested cortical spreading depression was developed and recorded after 1-3 minutes of seizures activity. 2. Mitochondrial NADH redox state was more oxidized during the two events. 3. The oxidation of NADH during the Cortical Spreading Depression- CSD was 3-4 times relative to the seizure’s interval. 4. The increase in extracellular potassium levels was also 3-4 times higher during the CSD event. Significance: Under the two recorded events a clear correlation between the process of oxygen (energy) demand or consumption and oxygen (energy) supply was found. The results suggest that the accumulation of extracellular potassium during the epileptic activity is probably the trigger for the development of CSD in the 3 model used.
The evaluation of the German SARS-CoV-2 test strategy - a multifactorial view
Authors: Homagk Lars
Published: July 2023

With SARS-CoV-2 in 2019 a coronavirus started circulating, for which the population showed no specific defense mechanisms of the immune system due to its clear distinction from the previously circulating coronavirus strains. Nevertheless, in 2021 there was a significant decrease in respiratory infections with a simultaneous significant increase in pandemic-related SARS-CoV-2 infections found. There is also a reduction in reported cases of respiratory diseases, especially in the pandemic year 2021. The aim of this study is to show optimizations in the test strategy during a pandemic and thus derive the improvement of civil protection. For Evaluation the data of GrippeWeb, the RKI’s Survstat® tool and the RKI’s reporting data on the new coronavirus were used. In addition, an evaluation of billing data from the EBM from 2017 to 2022 for the GOP 32816 as well as an evaluation of data on sick leave and illness statistics from 2019 to 2021 and the consideration of inpatient and outpatient health costs based on the data requested in writing from the Federal Ministry of Health was performed. The data from the Influenza Working Group shows an average of 300,000 annual reports for ARI per year. In 2019 it increased to 1,985,985 reports, in 2020 (5,453,017) and in 2021 to 29,681,158.There is also a correlation between the SARS-CoV-2 test frequency and the positive results, as well as an increase in the previously 6% positive rate for SARS-CoV-2 to over 50% in 2022. At the same time decreases the medical burden due to acute respiratory diseases (ARI) contrary to the increase of the acute respiratory diseases reported to the RKI with 2684%. What has been neglected so far is that corona viruses (HCoV) have been responsible for around 5- 10% of acute respiratory infections for decades. The comprehensive Covid-19 control measures, including the obligation to wear masks, apparently had no significant impact on reducing the spread of Covid-19, since there was also no decrease in infections with the adenovirus or RS virus in 2020 and 2021. Furthermore, an infection positive rate should not be used as a criterion for infection avoidance strategies and the recording of test results should always be validated and controlled. Only the testing of symptomatic persons should be remunerated and only these validated test results should be considered in the registration. In addition, the DIVI register for the inpatient area with recording of the main admission diagnosis and the data from the electronic transmission of sick notes to the health insurance companies for the outpatient area could be used in real time to decide on containment measures in the context of the pandemic.
Alpha-Fetoprotein: A Revolutionary Anti-Cancer Drug
Authors: Pak Vladimir
Published: July 2023

Alpha-fetoprotein is an oncofetal protein the embryo produces during fetal development. The protein serves two critical functions simultaneously: it delivers nutrients to growing embryo cells and immature myeloid-derived suppressor cells, so the mother’s immune system doesn’t attack the embryo. The protein is present in minuscule amounts in adults and elevated alpha-fetoprotein levels serve as pregnancy or tumor markers. Exogenous alpha-fetoprotein has a new application as an immunotherapy drug. It can deliver drugs in a natural shuttle manner to myeloid-derived suppressor cells and stimulate them to calm the hyperactive immune response during many physiological and pathological conditions. On the other hand, alpha-fetoprotein loaded with toxins kills myeloid-derived suppressor cells and unleashes natural killer cells and cytotoxic lymphocytes to erase cancer. Most cancers have cells that specifically bind alpha-fetoprotein, and this protein targets chemotherapy to them also. So, alpha-fetoprotein with toxins combines both potent cancer immunotherapy and targeted chemotherapy activities. Alpha-fetoprotein can be chemically conjugated with or bind toxins non-covalently. Both preparations have demonstrated superior efficacy and safety compared to chemotherapy alone. Alpha-fetoprotein-toxin immuno/chemotherapy is not personalized. There is no need to preselect patients for cancer treatments as they have elevated myeloid-derived suppressor cell levels. The anti-cancer efficacy of porcine alpha-fetoprotein non-covalent complexes with selected toxins administered orally is a remarkable discovery that needs research. Cancer treatment and prevention are different issues, and they could need different approaches. Alpha-fetoprotein administration with drugs or toxins could be as effective in early cancer and metastasis prevention as mifepristone pills in pregnancy prevention.
Вопросы обеспечения промышленной безопасности на объектах нефтегазовой отрасли
Authors: Александрова В.Е.
Published: July 2023

В данной статье рассматривается вопрос обеспечения пожарной безопасности объектов нефтегазового комплекса, который в современном мире стал как никогда остро, поскольку произошел резкий скачок роста строительства объектов нефтегазовой отрасли промышленности. Вместе с ростом предприятий происходит и усложнение технологических процессов и производств, что влечет за собой увеличение количества взаимосвязанных элементов, и как следствие, рост возможных отказов. Особое внимание к обеспечению, в том числе, и пожарной безопасности особо опасных объектов нашло свое отражение в законодательстве Российской Федерации
Предложение по разработке технологии биоконверсии осадков сточных вод
Authors: Дистанов., Р.Ш , Семѐнова . О.Л
Published: July 2023

В данной статье приведен вариант решения проблем утилизации осадков сточных вод, предполагающий использование ресурсосберегающей технологии биоконверсии с внедрением биогазовой установки для выработки электрической энергии
Автоматизация процесса выявления нарушений правил на волейбольных матчах с использованием систем видеофиксации и алгоритмов компьютерного зрения
Authors: Котов А.Е. , Трофимова Е.В.
Published: July 2023

В статье рассматриваются существующие проблемы автоматизации процессов принятия решений в спорных ситуациях на волейбольных матчах с использованием систем видеофиксации и алгоритмов компьютерного зрения на примере реализации такой системы в автономной некоммерческой организации «Волейбольный клуб «Зенит – Санкт-Петербург»»
Разработка приложения подбора средств контейнеризации для различных сервисных платформ
Authors: Чернышев В.А , Трофимова Е.В.
Published: July 2023

В статье рассматривается проблема выбора средств контейнеризации программного обеспечения для различных серверных платформ, приведен тщательный и детальный анализ доступных технологий контейнеризации. Описано разработанное автором приложение для сравнения средств контейнеризации на основе классификации. Подробно рассмотрены технологии для реализации разработки программного обеспечения для подбора средств контейнеризации. Приведен пример использования разработанного приложения для выбора средств контейнеризации для LMS-системы Университета ИТМО, сравнивались такие аспекты, как время работы и используемые ресурсы
Проблемы систем регистрации и аутентификации в web-приложении
Authors: Александрова Л.Н , Самсонов И.Ю
Published: July 2023

В статье затрагиваются некоторые проблемы, возникающие при обмене данными между страницами сайта, в частности при регистрации и аутентификации клиентов. Описаны способы хранения информации на стороне клиента и сервера, проанализированы их преимущества и недостатки. Приведены примеры реализации программного кода.
Перспективы перехода электронного правительства к цифровому на примере развития и совершенствования СЭД
Authors: Бабкина А.О, , Мхитарян Л.А, , Перова М.В.
Published: July 2023

Данная научно-исследовательская работа посвящена анализу процесса перехода электронного правительства к цифровому. Основой для анализа выступают практические примеры внедрения, развития и совершенствования СЭД в государственных структурах России. Определены некоторые аспекты развития СЭД в системах электронного правительства, выделены шаги для дальнейшего наиболее эффективного перехода к цифровому правительству
Обзор и сопоставление в задачах обработки естественного языка сверхточных и рекуррентных нейронных сетей
Authors: Бритов В.С , Мартышкин А.И. , Данилов Е.А
Published: July 2023

В статье представлены современные подходы в обработке естественного языка с использованием нейронных сетей, такие как рекуррентные и сверточные нейронные сети и нейросети на основе транформеров, с целью изучения их видов, преимуществ использования, основных принципов работы и сравнения между собой.
Применение нейронных сетей для автоматизации процессов проверки домашних заданий, экзаменов, обнаружения и исправления ошибок в выполняемых студентами задачах
Authors: Данилюк А.И , Баринов Д.М , Косьянова М.С
Published: July 2023

Данная статья рассматривает возможности применения нейронных сетей для автоматизации процессов проверки домашних заданий, экзаменов, а также обнаружения и исправления ошибок в задачах, выполняемых студентами. В статье описывается, как нейронные сети могут помочь улучшить качество обучения студентов, выявляя популярные ошибки, которые они совершают при выполнении задач, и предлагая соответствующие рекомендации. Также обсуждаются возможности снижения количества ошибок, допущенных при проверке домашних заданий и экзаменов, благодаря использованию нейронных сетей. В статье подчеркивается, что правильное обучение и настройка нейронных сетей, а также использование данных высокого качества, являются ключевыми факторами для достижения наилучших результатов в образовательной сфере
Создание графического интерфейса пользователя кроссплатформенного приложения, используя фреймворк flutter
Authors: Лаврентьев Д.О., , Белаш В.Ю.
Published: July 2023

Статья посвящена вопросам разработки интерфейса пользователя для кроссплатформенного приложения «Электронный журнал». Рассмотрен вопрос о возможностях фреймворка flutter, приведены примеры реализации элементов пользовательского интерфейса.
Об оценке среднего ускорения последовательной композиции конвейерных систем с ограничениями
Authors: Трещев И.А.
Published: July 2023

В работе рассмотрены конвейерные системы, для которых формально введена операция параллельной и последовательной композиции. Для последовательной композиции конвейерных систем с ограничениями приводится среднее ускорение вычислений. Сформулирована теорема для оценки максимально достижимого ускорения последовательной композиции группы конвейерных систем.
Восстановление срока исковой давности
Authors: Редин И.С.
Published: July 2023

Статья посвящена проблеме восстановления срока исковой давности, обусловлено, что следует понимать под восстановлением срока исковой давности и какие обязательные условия применяются судами для восстановления срока исковой давности.
СКВ как проблема диагностики в педиатрии (клинический случай)
Authors: Молдатилесова Н.К. , Мырзатай М.Е. , Сыдық П.Ж. , Баймаханова Г.Қ. , Скосарев И.А.
Published: July 2023

Представлен краткий анализ распространенности, заболеваемости системной красной волчанки у детей, с последующим изложением клинического случая данного заболевания у ребенка Б. 15л. , при значительных трудностях постановки диагноза.