bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of postnatal exposure to mixtures of bisphenol A and phthalates on children’s IQ at 5 years of age: Mothers and Children's Environmental Health (MOCEH) Study
Authors: Ham Da Jeong , Ha Mina , Park Hyesook , Hong Yun-Chul , Kim Yangho , Ha Eunhee , Bae Sanghyuk
Published: March 2023

Background

Early childhood is important for neurodevelopment, and exposure to endocrine disruptors such as bisphenol A (BPA) and phthalates in this period may cause neurodevelopmental disorders and delays. The present study examined the association between exposure to mixtures of BPA and phthalates in early childhood and IQ at 5 years of age.

Methods

The Mother and Children's Environmental Health (MOCEH) study is a prospective birth cohort study conducted in Korea with 1751 pregnant women enrolled from 2006 to 2010. A total of 152 children was included in the analyses. We measured children’s urinary concentrations of metabolites of endocrine-disrupting chemicals (BPA, mono-(2-ethyl-5-oxohexyl) phthalate, mono-(2-ethyl-5-hydroxyhexyl) phthalate, and mono-(2-ethyl-5-butyl) phthalate) at ages of 24 and 36 months. We evaluated the children’s IQ with the Korean Wechsler Intelligence Test at the age of 5 years. After adjusting for potential confounders, a multiple linear regression was conducted to examine the associations between individual endocrine-disrupting chemicals and the IQ of the children. Weighted Quantile Sum (WQS) regression and quantile-based g-computation were used to assess the association between IQ at age 5 and exposure to mixtures of BPA and phthalates.

Results

In the single-chemical analyses, mono-(2-ethyl-5-butyl) phthalate exposure at 36 months was adversely associated with children’s IQ (β = -4.93, 95% confidence interval (CI): -9.22, -0.64). In the WQS regression and quantile-based g-computation analyses, exposure to the mixture of BPA and phthalates was associated with lower IQ [β = -9.126 (P-value = 0.051) and β = -9.18 (P-value = 0.049), respectively]. The largest contributor to the overall association was exposure to mono-(2-ethyl-5-butyl) phthalate at 36 months.

Conclusions

In the present study, postnatal exposure to mixtures of BPA and phthalates was associated with decreased IQ of children at age 5.

Trial registration

Not applicable
Suitable habitats shifting toward human-dominated landscapes of Asian elephants in China
Authors: Yu Qiupeng , Hu Zhechang , Huang Cheng , Xu Tongmei , Onditi Kenneth Otieno , Li Xueyou , Jiang Xuelong
Published: March 2023

Although intensifying human activity in Asian elephants' natural habitats has led to gradual habitat changes, fragmentation, and contraction in recent decades, their population has continued to increase and disperse due to a series of conservation efforts, resulting in increased severe human-elephant conflicts. The habitat adaptation strategies of Asian elephants remain unclear. Here, we used the maximum entropy models to explore habitat selection strategies of Asian elephants at different spatial scales in Southwest China based on the occurrence data. Using habitat suitability predictions, we identified the key environmental, anthropogenic, and climatic variables influencing Asian elephants' habitat utilization. We also assessed the historical dispersal trend of Asian elephants and the overlap between suitable habitat ranges and human-dominated regions. The results showed that inherent topographic variables, such as elevation and slope, strongly influence the habitat selection of Asian elephants across spatial scales and that human activity influence is stronger at larger scales. There is currently approximately 17,744 km2 of suitable habitat and 25,590 km2 of sub-suitable habitat for Asian elephants in China, mainly in Xishuangbanna and central and south Pu'er, with 63.73% of these habitats overlapping human-dominated regions. Under the high-emissions climate change scenario, suitable and sub-suitable habitats of Asian elephants would shrink by 61% and 31% by the 2050s. In areas of high overlaps between suitable habitats of Asian elephants and human-dominated regions, strategies such as habitat restoration, construction of ecological corridors, and land use improvement could effectively alleviate human-elephant conflict and promote human-elephant coexistence.
Analysis of genomic copy number variation in 48 azoospermia patients with chromosomal abnormalities
Authors: liu yongjie , Shi Dongmei , Dai Liang , Zhang Fan , Wang Guoping
Published: March 2023

Background: To explore the copy number variation (CNV) of genome in azoospermia patients with chromosomal abnormalities, and to lay a foundation for elucidating the genetic factors of spermatogenesis.
Methods: 204 patients with azoospermia were analyzed by G banding karyotype analysis; The next generation sequencing technology (NGS) is used to detect CNV, screen out CNVs related genes, and determine by referring to the latest published data of human genome hg19 version, genome variation database (DGV), human chromosome imbalance and phenotype database (DECIPHER), online human Mendelian genetic database (OMIM), University of California Santa Cruz database (UCSC), PubMed and other public databases. All data are entered into EXCEL table, and the percentage and proportion of each indicator are statistically analyzed.
Results: Among 204 patients with azoospermia, 48 patients had chromosomal abnormalities (23.53%), of which 47, XXY (47.92%), 46, X, Yqh - (12.50%), 46, XY, 16qh+(6.25%) accounted for more than 5%; Chromosome abnormalities were found in 48 patients, including 43 patients with CNV, including 28 patients with 1 CNV, 11 patients with 2 CNVs, 2 patients with 3 CNVs, and 2 patients with 4 CNVs. The X chromosome (39.68%), Y chromosome (14.29%), and chromosome 15 (6.35%) accounted for more than 5% of the total; Among 63 CNVs, the fragment size was 0.10~2.38Mb, and 90 related genes were detected, including 26 deletions and 64 repeats.
Conclusion:G-banding karyotype analysis combined with NGS detection can provide more complete genetic evaluation for azoospermic patients, which is worth popularizing.
High throughput 13C-metabolic flux analysis of 3-hydroxypropionic acid producing Pichia pastoris reveals limited availability of acetyl-CoA and ATP due to tight control of the glycolytic flux
Authors: Fina Albert , Millard Pierre , Albiol Joan , Ferrer Pau , Heux Stephanie
Published: March 2023

Background
Production of 3-hydroxypropionic acid (3-HP) through the malonyl-CoA pathway has yielded promising results in Pichia pastoris (Komagataella phaffii), demonstrating the potential of this cell factory to produce this platform chemical and other acetyl-CoA-derived products using glycerol as a carbon source. However, further metabolic engineering of the original P. pastoris 3-HP-producing strains resulted in unexpected outcomes, e.g. significantly lower product yield and/or growth rate. To gain understanding on the metabolic constraints underlying these observations, the fluxome of ten 3-HP-producing P. pastoris strains has been characterized using a high throughput 13C-metabolic flux analysis platform.
Results
Results indicate that the expression of the NADH kinase leads to a reduction in the fluxes of the pentose phosphate pathway reactions. Moreover, an increase in the pentose phosphate pathway fluxes was observed when the cytosolic acetyl-CoA pathway was overexpressed. Results also show that the tight control of the glycolytic flux hampers cell growth due to limited acetyl-CoA biosynthesis. When the cytosolic acetyl-CoA synthesis pathway was overexpressed, the cell growth increased, but the product yield decreased due to higher growth-associated ATP costs. Finally, the six most relevant strains were also cultured at pH 3.5 to characterize their fluxome. Similar results were obtained at pH 3.5 and pH 5.
Conclusions
The reported results provide valuable information on the adaptation of the fluxome of Pichia pastoris when genetic modifications are made to increase the availability of NADPH and cytosolic acetyl-CoA. Such knowledge can guide further metabolic engineering of these strains. Moreover, the first insights into the adaptation of P. pastoris to an acidic pH are also provided, which is of high interest for the downstream processing of carboxylic acids production.
Exploring sensory sensitivity, cortical excitability, and habituation using the pattern-reversal task across the episodic migraine spectrum: A case-control study
Authors: Marti-Marca Angela , Vilà-Balló Adrià , Cerdá-Company Xim , Ikumi Nara , Torres-Ferrus Marta , Caronna Edoardo , Gallardo Victor J , Alpuente Alicia , Torralba Mireia , Soto-Faraco Salvador , Pozo-Rosich Patricia
Published: March 2023

Background
Migraine is a cyclic, neurosensory disorder characterized by recurrent headaches and altered sensory processing. In particular, hypersensitivity to visual stimuli, measured with questionnaires and sensory thresholds, as well as abnormal cortical excitability, and a lack of habituation, assessed with visual evoked potentials elicited by pattern-reversal stimulation, have been reported. Here, the goal was to assess sensory sensitivity, cortical excitability, and habituation using two experiments and determine whether factors such as age and/or disease severity may exert a modulatory influence on them.
Methods
Two similar experiments were carried out, the first comparing 24 young, episodic migraine patients and 28 healthy age- and gender-matched controls and the second 36 middle-aged, episodic migraine patients and 30 healthy age- and gender-matched controls. A neurologist confirmed the diagnoses. Migraine phases were obtained using eDiaries. Sensory sensitivity was assessed with the Sensory Perception Quotient and group comparisons were carried out. We obtained pattern-reversal visual evoked potentials and calculated the N1-P1 Peak-to-Peak amplitude. Two linear mixed-effects models were fitted to this data. The first model had Block (first block, last block) and Group as fixed factors, whereas the second model had Trial (all trials) and Group as fixed factors. Participant was included as a random factor in both. N1-P1 first block amplitude was used to assess cortical excitability and habituation was defined as a decrease of N1-P1 amplitude across Blocks/Trials. Both experiments were performed interictally.
Results
The final samples consisted of 18 patients with episodic migraine and 27 headache-free controls (first experiment) and 19 patients and 29 controls (second experiment). In both experiments, patients reported increased visual hypersensitivity on the Sensory Perception Quotient as compared to controls. Regarding N1-P1 peak-to-peak data, there was no main effect of Group, indicating no differences in cortical excitability between groups. Finally, significant main effects of both Block and Trial were found indicating normal habituation in both groups, regardless of age and headache frequency.
Conclusions
The results of this study yielded significant hypersensitivity in patients but similar habituation and cortical excitability, as compared to headache-free controls. Therefore, the mechanisms of sensory-attentional processing in response to PR stimulation may be mostly intact.
Implementation of Block-Based Diagonal and Quadrantal Symmetry type 2D-FIR Filter Architectures using DA Technique
Authors: R V. Srilatha , Juliet A. Vimala , Thuraka Esther Rani , Odugu Venkata Krishna
Published: March 2023

An efficient architecture of two-dimensional (2D) Finite Impulse Response (FIR) filters is required to process the images. The architectures implemented in VLSI design and optimization achieve better performance in terms of metrics such as power consumption, area, and delay. The 2D FIR filter architectures can be implemented using parallel or block processing to increase the throughput of the architecture and to prune the number of clock cycles required for image processing. The symmetry in the filter coefficients decreases the number of multipliers, whereas the multiplier block is very complex and a power hunger block in the filter architecture. In this work, two types of symmetry architectures such as diagonal symmetry and quadrantal symmetry filters are proposed. The remaining multipliers required for the filter architecture are replaced by Distribute Arithmetic (DA) logic. The memory-based DA reduces the LUT size and hence the area, power, and delay are reduced in the filter architecture. Block processing, symmetry, and DA concepts are introduced here to optimize the 2D FIR filter architecture. The proposed architectures are implemented in 45nm CMOS technology using Cadence Genus Synthesis tools and area, delay, power, Area-Delay Product (ADP), and Power-Dealy Product (PDP) results are obtained and compared with state-of-the-art works. The ADP value of the proposed diagonal symmetry architecture is decreased by a maximum of 73.35%, and a minimum of 28.9%, and the PDP value is decreased by a maximum of 87%, and a minimum of 21.27% when compared to the existing works. The ADP and PDP values of the proposed quadrantal symmetry are decreased by a minimum of 28.9%, and 27.74% when compared to the works, respectively.
Acetone O-(2-naphthylsulfonyl)oxime Alleviates the Toxic Effects of Cadmium Stress in Maize Seedlings by Increasing the Phenolic Substance Content and Antioxidant System Activity
Authors: YETİŞSİN Fuat , AHNEAK Esin
Published: March 2023

Cadmium (Cd) is a heavy metal that can have toxic effects on plants even in trace amounts in the soil. In this study, we aimed to elucidate the role of exogenous O-(2-naphthylsulfonyl)oxime (ANSO) in maize plants under Cd stress. For this purpose, the following experimental groups were formed: The control group will be kept in distilled water for 18 hours, the second group will be kept in ANSO (0.3 mM) for 6 hours and then in distilled water for 12 hours, the third group will be in distilled water for 6 hours and then in Cd solution (100 μM) for 12 hours, fourth group ANSO (0.3 mM) for 6 hours, followed by 12 hours of Cd solution (100 µM). When ANSO+Cd application is compared to Cd, the Cd content increased 7.8 times, while the ABA content decreased. RWC content, which was reduced by Cd stress, was not changed by ANSO pre-treatment. Chlorophyll content, which decreased with Cd treatment, increased with ANSO+Cd treatment. While the carotenoid content increased with Cd application, it increased much with ANSO+Cd application. The H2O2 content and lipid peroxidation increased in the plant with Cd stress and decreased with ANSO pre-treatment. With ANSO+Cd treatment, GPX activity decreased compared to Cd treatment, but CAT and APX values increased. ANSO pre-treatment did not significantly change SOD activity. Cd application increased proline content compared to control, but proline content decreased compared to Cd with ANSO pre-treatment. In ANSO+CD application, ascorbic acid, cinnamic acid and catechol values increased compared to the values in plants treated with Cd alone, but the trans-coumaric acid value decreased. As a result, it can be said that ANSO pre-application to maize seedlings under Cd stress provides the preservation of the ion balance of the cells by chelating Cd+2 ions in the cell wall and vacuoles.
Effect of early administration of tolvaptan on pleural effusion post-hepatectomy
Authors: Iida Hiroya , Maehira Hiromitsu , Mori Haruki , Nitta Nobuhito , Maekawa Takeru , Takebayashi Katsushi , Kaida Sachiko , Miyake Toru , Tani Masaji
Published: March 2023

Purpose: In this study, the efficacy of tolvaptan administration at the early stage post-hepatectomy was evaluated to control pleural effusion and improve the postoperative course.
Methods: Patients were administered tolvaptan (7.5 mg) and spironolactone (25 mg) from postoperative day 1 to 5 (tolvaptan group, n=68) for 13 months. Early administration of tolvaptan was not given in the control group (n=68) but diuretics were appropriately administered according to the patient's condition. The amount of pleural effusion on computed tomography on postoperative day 5 was compared between the two groups.
Results: The amount of pleural effusion and increase in body weight on postoperative day 5 showed significant differences in both groups (p<0.001 and p=0.019, respectively). However, the rate of pleural aspiration and the duration of postoperative hospitalization did not show any significant differences. The amount of intraoperative blood loss and lack of early administration of tolvaptan were identified as independent risk factors contributing to pleural effusionon multivariate analysis.
Conclusion: Early administration of tolvaptan to post-hepatectomy patients was found to be capable of controlling postoperative pleural effusion and increase in body weight, but it did not reduce the rate of pleural aspiration or the hospitalization period.
Increasing incidence of syphilis among men living with HIV in Croatia during the COVID-19 years 2020 and 2021
Authors: Begovac Josip , Pintar Vanja Romih , Vrsaljko Nina , Močibob Loris , Bogdanić Nikolina , Zekan Šime , Rode Oktavija Đaković
Published: March 2023

We conducted a nationwide longitudinal observational study to estimate the incidence of syphilis in a cohort of male persons living with HIV (PLWH) in Croatia in the pre-COVID-19 and COVID-19 years. Data were reviewed and extracted from the clinical database. We analyzed 1187 PLWH (> 18 years) in care in Croatia from 2018 to 2021 and used Poisson regression to calculate rates. We observed a 91.4% increase in incidence between 2019 and 2020; the overall rate was 6.0/100 person-years, and the annual rate ranged from 3.3/100 person-years in 2018 to 9.3/100 person-years in 2021. We found higher rates in men who have sex with men, PLWH with a baseline history of syphilis, PLWH with a more recent HIV diagnosis, and a lower rate in those who had clinical AIDS. The rate of syphilis serological testing was 3.5% lower in 2020 compared to 2019. Recurrent syphilis was more likely asymptomatic compared to the first episodes. In conclusion, during the COVID-19 epidemic years there was a huge increase in syphilis. Results highlight the need for enhanced and novel prevention interventions.
Involvement of ApoE4 in dementia with Lewy bodies in the prodromal and demented stages: evaluation of the Strasbourg cohort
Authors: Bousiges Olivier , Cretin Benjamin , Muller Candice , Botzung Anne , Sanna Lea , Anthony Pierre , Philippi Nathalie , Demuynck Catherine , Blanc Frédéric
Published: March 2023

Background:ApoE4 as a risk factor for AD is no longer a matter of debate. However, it is still an issue for dementia with Lewy bodies (DLB).We wanted to determine the involvement of ApoE4 according to different clinical parameters in our cohort of patients from Strasbourg.Methods:ApoE genotyping was performed on the AlphaLewyMA cohort. In this cohort, 197 patients were genotyped. Among them 105 DLB patients, 37 Alzheimer’s disease (AD), 29 comorbidity AD/DLB and 26 control subjects (CS). These groups are also classified according to the stage of evolution of the disease: prodromal or demented. We analyzed other parameters in relation to ApoE4, such as socio-educational levels (SEL) and Alzheimer CSF biomarkers (t-Tau, P-Tau, Aβ-42 and Aβ40).Results:There were significantly more ApoE4 carriers in the AD (51.4%) and AD/DLB (72.4%) groups compared to the DLB (25.7%) and CS (11.5%) groups (P<0.0001). No significant difference was found between the percentage of ApoE4 in the DLB and CS groups, idem between AD and AD/DLB groups. For AD group, we find a correlation between the age of onset of the disease and the SEL. For DLB group, the correlation does not reach significance despite a strong trend (p = 0.056). Interestingly, in this latter group, taking the median of SEL (Education=11 years, i.e. one year before bachelor), the group of patients with high SEL (≥ 11) has significantly more patients with ApoE4 than the group of patients with low SEL (<11). Finally, the AD biomarkers do not seem to be impacted by the presence of ApoE4, except for Aβ42. DLB ApoE4 demented patients show a more marked decrease of CSF Aβ42.Conclusions:ApoE4 does not appear to be a risk factor for “pure” DLB patients with the possible exception of patients with high SEL. In the DLB group, ApoE4 would be responsible for the Aβ42 decrease between the prodromal and demented group, suggesting a strong link between ApoE4 and amyloidopathy thus confirming its strong link with AD.Trial registration: ClinicalTrials.gov, (AlphaLewyMa, Identifier: NCT01876459)
Restructuration des répertoires langagiers de migrant·e·s de la République du Congo en Lorraine
Authors:   , Reimer Peter
Published: March 2023

Cette thèse étudie la complexité du plurilinguisme des migrant·e·s d’origine de la République du Congo en Lorraine à travers le prisme de la restructuration des répertoires langagiers. En affûtant la conceptualisation de la restructuration des répertoires langagiers par l’étude du plurilinguisme des migrant·e·s d’origine congolaise, cette recherche ouvre de nouvelles perspectives pour les recherches portant sur le plurilinguisme, notamment concernant les mobilités transgénérationnelles et la diversité des processus de restructuration façonnant les répertoires langagiers. En se focalisant sur les biographies langagières et migratoires de 15 individus migrants, sur leurs réseaux sociaux et sur leurs ressources langagières, cette étude révèle la diversité des processus et des facteurs au cœur des restructurations des répertoires langagiers à travers une étude ethnographique multi-située en Lorraine et au Congo. La compréhension de la diversité des dynamiques restructurant les connaissances langagières des enquêté·e·s passe par l’étude des situations de socialisation langagière au Congo dans leur historicité, des itinéraires de migration et des restructurations des réseaux sociaux ainsi que des répertoires langagiers dans l’installation en Lorraine. Les participations à la société lorraine et ses groupes sociaux imprègnent les identifications, les orientations sociales et les positionnements dans les réseaux sociaux et vice-versa. Les répertoires langagiers apparaissent comme des enregistrements de la mobilité des individus et de celle des générations antérieures ainsi que de leur entourage. Les restructurations concernent entre autres les ressources associées au français, aux langues congolaises et à d’autres langues appropriées par la migration. Les ressources du français sont restructurées par les migrant·e·s en s’appropriant les ressources courantes dans différentes situations sociales en Lorraine, en marquant et/ou en dissimulant les ressources appropriées ailleurs et inappropriées dans ces situations. En même temps, un savoir de différenciation des ressources, dont font aussi partie les schémas de catégorisation et les stratégies communicatives, est développé et une (in)sécurité langagière se manifeste. Les ressources associées aux langues congolaises, leurs fonctions sociales et leurs représentations sont restructurées dans des processus d’attrition, d’actualisation, de transformation et d’élaboration langagière. Les ressources associées à d’autres langues européennes appropriées par la migration sont reléguées au second plan et se perdent lentement par manque d’usage. Enfin, les connaissances liées à la gestion du plurilinguisme, de la diversité culturelle et de l’altérité, appropriées dans les mêmes situations de diversité, aident au traitement interne des expériences des mobilités spatiales et sociales ainsi que des restructurations des répertoires langagiers.
Day-extension Blue Light Inhibits Flowering of Chrysanthemum When the Short Main Photoperiod Includes Far-red Light
Authors: Kohler Annika E. , Birtell Eva M. , Runkle Erik S. , Meng Qingwu
Published: March 2023

Chrysanthemum (Chrysanthemum ×morifolium) is a common ornamental crop with a qualitative short-day flowering response. Extending a short day with moderate blue [B (400–500 nm)] light inhibits flowering in greenhouse conditions with sunlight but does not indoors (without sunlight) under B + red [R (600–700 nm)] light or white light. We postulated that the contrasting responses to B light as a day extension depended on far-red [FR (700–800 nm)] light during the day, which is plentiful under sunlight but lacking indoors under B+R or white light-emitting diodes. To study this response in three chrysanthemum cultivars, we delivered indoor lighting treatments at two locations with an 11-hour main photoperiod of B, green [G (500–600 nm)], R, and FR light, where subscript values indicate the photon flux density (in µmol·m−2·s−1) of each waveband: B60R120, B60G60R60, and B60R60FR60. After each short main photoperiod, plants received 0 or 4 hours of day-extension lighting of 60 µmol·m−2·s−1 of B light (B60). Under all treatments except B60R60FR60 with day-extension B60, it took ‘Chelsey Pink’, ‘Gigi Gold’, and ‘Gigi Yellow’ 13 to 17 days to reach the first visible inflorescence and 42 to 51 days to the first open flower. In contrast, plants grown under B60R60FR60 with day-extension B60 took 41 to 67 days to reach the first visible inflorescence with few plants developing open flowers. Plants were tallest at the first open flower and after 9 weeks of treatments when grown under B60R60FR60 with day-extension B60. These results indicate that the inclusion of FR light, but not G light, in the main photoperiod is necessary for day-extension B light to inhibit flowering in chrysanthemum. On the basis of these results and those of other studies, we postulate that the spectral dependence of flowering in chrysanthemum depends on whether and how the phytochrome photoequilibrium changes during the day. In particular, a sufficiently high daytime phytochrome photoequilibrium (e.g., under B+R and B+G+R light) could establish a predominant mode of floral signaling that prevents perception of subsequent B light as a long day.
Cuerpos excluidos en la escuela pública colombiana contemporánea: discursos y prácticas
Authors: Urrego Bolivar Edith Tatiana
Published: March 2023

El cuerpo como escenario de exclusión en la escuela pública colombiana, es una propuesta que consiste en un ejercicio de carácter descriptivo, motivado principalmente por una experiencia práctica de aula en una Institución educativa de Sabaneta, Antioquia, en los grados décimo y once, y seguidamente de la lectura de autores tales como Pablo Scharagrodsky, Mascareño, Martínez, entre otros, así como también de lineamientos normativos y constitucionales. El trabajo está enmarcado en la pregunta por el cuerpo como escenario de encuentros, desencuentros, posibilidades, pero a su vez de tensiones e interdicciones que lo regulan y configuran un ambiente social determinado. La reflexión examina prácticas y discursos segregacionistas sobre un cuerpo que excede la fisiología y que se constituye desde docentes y estudiantes como un territorio en el que subyacen ideas promotoras de un orden excluyente y legitimado en el tiempo, que segrega determinadas condiciones corporales tales como el color de piel, la fisionomía, la orientación social, el género, o la orientación religiosa.
Aprovechamiento energético del lavado industrial de la empresa Relianz CAT
Authors: Cardona-Palacio Luis Fernando , Martínez Monsalve Víctor Orlando
Published: March 2023

Se desarrolla un sistema de mejoramiento energético con los gases de escape generados a partir del proceso de lavado de componentes del taller de desarme de la empresa Relianz CAT, localizada en Soledad, departamento del Atlántico-Colombia. Inicialmente se realizaron mediciones para conocer las condiciones operacionales actuales del proceso y el análisis de los posibles flujos para realizar la mejora energética. Posteriormente, se realiza una búsqueda bibliográfica de técnicas utilizadas en la industria para la recuperación energética y así definir la red de intercambiadores de calor y servicios industriales necesarios para lograr un adecuado aprovechamiento de la energía térmica de la empresa. A partir de lo anterior se decidió proponer un intercambiador de tubos y coraza TEMA G de cuatro pasos por los tubos, 246 tubos y 1,8 m de longitud. Se logra una temperatura de precalentamiento de agua superior a los 60 °C con un ahorro energético de 2653 kW, en cuanto al vapor de salida se tiene un flujo de condensado 1,11 kg/s. Con el intercambiador de calor de tubos y coraza propuesto se lograría un ahorro mensual de COP 51.383.040 y un tiempo de recuperación de la inversión inferior a dos meses. Además, con la propuesta de diseño se tiene un ahorro de emisiones de dióxido de carbono de 26 toneladas de dióxido de carbono por año y un posible ahorro de volumen de agua mensual de 28877 m3 que puede ser utilizado en sistemas de riego, limpieza inicial de componentes, y aseo de instalaciones.
Influencia de la música en el comportamiento de los adolescentes
Authors: Marín Jhon Steven
Published: March 2023

La música ha acompañado al ser humano y, además, ha servido como elemento para identificar culturas y maneras de actuar. En la actualidad se conoce que está directamente relacionada con nuestra actividad cerebral, generando así toda clase de estímulos que pueden llegar al movimiento. Hoy en día, los ritmos y melodías tienen más lugar en la sociedad. La música llega al hombre tanto por gusto, como por saturación de su exterior. Esto ocurre en gran medida con los jóvenes, quienes en su nueva etapa buscan otros ambientes en los cuales puedan interactuar y sentirse identificados, uno de estos es el musical, aquel que se encuentra bajo una industria bastante globalizada que puede llegar a casi todas partes del mundo. Sin embargo, esta relación puede generar comportamientos rebeldes e inapropiados en los adolescentes, pues con quienes negocian su identidad, les interesa más las ganancias que pueden generar las canciones, que los efectos comunicativos que esta ejerce en los adolescentes. Por esta razón, es necesario que la sociedad le dé más visibilidad a la música y lo que esta puede traer en el comportamiento de los jóvenes.
Celos patológicos e impulsividad: un actual dilema en las relaciones de pareja
Authors: Pimienta Sierra María Isabel , Arias Henao Leidy Johana , Urango Rodríguez Sindy Marcely , Calle Muñoz Raul Antonio , Tapias Medina Yesid Felipe , Carmona-Cardona César Andrés
Published: March 2023

Aunque los celos patológicos y la impulsividad son temas que han estado presentes en la literatura y que actualmente afectan las relaciones de pareja, existe una controversia en cuanto a la relación entre ambos. El propósito del presente artículo es analizar los celos patológicos y la impulsividad desde diferentes planteamientos y cómo influyen entre sí en ciertos comportamientos considerados mal adaptativos, que no solo afectan a la persona que los sufre, sino también a la pareja. Seencontraron siete estudios que examinaron la impulsividad en relación con los celos patológicos, de estos, dos encontraron una estrecha correspondencia entre ambas variables de las cuales se plantea que la impulsividad como rasgo estápresente en los celos patológicos y generan un desajuste social; otros estudios correlacionan las variables por medio de distintos factores influyentes (trastornos de personalidad, psicopatía, apego ansioso ambivalente).
Reflexión sobre las emociones políticas
Authors: Arbeláez Ochoa John
Published: March 2023

Durante los recientes comicios para elegir al presidente de la República de Colombia, tuvimos ocasión de ser testigos de la más despreciable manipulación de las emociones de un pueblo ignaro, alimentadas por la ira de unos y el miedo de otros y, en general, por una crasa ignorancia sobre lo que debe ser la conciencia política seria, cimentada en reflexiones y análisis para llegar a fondo y comprender las propuestas de cada uno de los candidatos...
La Igualdad de las mujeres y los hombres, evolución ineludible de la humanidad
Authors: Pareja Reynaldo
Published: March 2023

La Igualdad de las mujeres y los hombres, es una evolución ineludible de la humanidad a pesar de las estructuras sociales, económicas y políticas que han mantenido el dominio masculino sobre las mujeres durante tantos miles de años, antes de que comenzara a darse un cambio dramático hacia finales del siglo XIX y a lo largo de todo el siglo XX con una continuación obvia en el siglo XXI...
Relationship between determinants of higher education and economic development: The case of Kazakhstan
Authors: Karabayev Shyngys , Nurgaliyeva Kuralay , Kredina Anna , Bekturganova Makpal , Aimagambetov Yerkara
Published: March 2023

This study aims to examine the relationship between higher education and economic development determinants in Kazakhstan’s regions. The paper used two sets of indicators of three-time series: 2010, 2015, and 2020. The analysis constructed a correlation using a panel dataset for 15 regions of Kazakhstan compiled by the Statistics Bureau of Kazakhstan and the National Bank. The first set reflects the determinants of higher education (number of students in colleges and universities, number of teaching staff, and the existing ICT infrastructure in universities). The second set includes indicators of regional economic development (GRP per capita and the population’s income level). The results showed a causal relationship between economic development and the determinants of higher education in the regions of Kazakhstan, which depend on the period. Surprisingly, the number of university students has almost no effect on GRP per capita and the population’s income level. For 2015–2020, the study observed the emergence and strengthening of correlations between economic growth and the development of innovations in universities. The findings also identified Mangystau, Atyrau, North Kazakhstan, and Pavlodar as regions with low innovation development in education. Therefore, the country’s higher education development policy should encourage and strengthen knowledge management systems in these regions. The study concludes that higher education and economic indicators significantly influence the growth of the economy in Kazakhstan.
AcknowledgmentThe study was carried out within the framework of program-targeted IRN BR18574240 funding by the Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan “Development Strategy of Kazakhstan Regional Potential: Assessment of Socio-Cultural and Economic Potentials, Roadmap, Models and Scenarios Planning”.
ENGELLİ EVDE BAKIM HİZMETLERİNDE KARŞILAŞILABİLECEK SORUNLAR ÜZERİNE BİR DEĞERLENDİRME
Authors: KÖK Hilal
Published: March 2023

Engelli evde bakım hizmetlerinin temel amacı engelli bireyin yaşamını aile içinde destekleyerek bağımsız yaşamına katkı sunmaktır. Engelli evde bakım hizmetleri engellinin evinde ihtiyaçlarının giderilmesine yönelik çalışmaları içermektedir. Engelli evde bakım aylığı ise informal bakım olarak nitelendirilen ağır engelli bireye akrabası tarafından bakım sorumluluğunun yerine getirilmesi karşılığında her ay düzenli olarak ödenen nakdi yardımdır. Bu derleme makalede öncelikle evde bakım kavramı, evde bakım hizmeti ihtiyacı, evde bakım hizmetinin amacı ve bu hizmetin mevzuat temellendirmesine değinilerek evde bakım hizmeti ve evde bakım aylığı uygulamalarında karşılaşılabilecek birbirinden farklı sorunlar tartışılmıştır. Sorunlara ilişkin değerlendirme ve çözüm önerileri mevcut uygulamalar, engelli birey, bakım veren ve uygulayıcılar perspektifinden ele alınmıştır. Çalışmada engelli evde bakım hizmet sunumu, gelir kriteri, mevzuat, yapılan sosyal incelemeler, uygulayıcıların niteliği, bakım verenin ihtiyaçları vb. pek çok konunun ele alınarak değerlendirilmesi amaçlanmıştır. Son olarak yapılan değerlendirmeler ışığında uygulamalardaki olası sorunların giderilerek hizmet sunumundaki kalitenin artırılmasına dair pek çok öneri sunulmuştur.
YAPISAL VE SAYISAL ÖZELLİKLERİYLE TÜRK TOPLUMUNDA AİLE: GEÇ OSMANLI VE ERKEN CUMHURİYET DÖNEMİ MAHKEME KAYITLARINA GÖRE MUCUR AİLESİ
Authors: KARAKILIÇ Cem
Published: March 2023

Mahkeme kayıtları bir toplumun bütün kodlarını içinde barındıran ayrıntılı envanterdir. Burada aile bağının kuruluş öyküsünü, evlenme ve boşanma usullerini, şiddetin aileye yansıyan yüzünü, İslam hukukunun pratiklerini, ailenin ekonomik faaliyetlerini, üretim ve tüketim stratejilerini ya da içinde yaşadığı kolektif mekânların özelliklerini bulmak mümkündür. Bu çalışmanın amacı mahkeme kayıtlarından yola çıkarak Osmanlı ve erken cumhuriyet dönemi Mucur ailesi hakkında senkronik ve diyakronik bir okuma gerçekleştirmek, hane halkının sayısal ve yapısal özelliklerini kullanarak yörenin sosyo-kültürel ve sosyo-ekonomik özelliklerini tespit etmek, ailenin teamül ve temayüllerini maksimize etmek suretiyle insanı, haneyi, sokağı, ve toplumu anlamaya çalışmaktır. Araştırma konumuz çalışmanın sınırlarını ve kapsamını içeren kısa bir giriş ile Mucur ailesinin yapısal ve sayısal özelliklerini-tabi ki, mahkeme kayıtlarına yansıyan yüzüyle- ihtiva eden beş başlıktan oluşmaktadır. Araştırma yöntemimiz örnek olay incelemelerine dayanan dolaylı (vasıtalı) gözlemlerdir. Araştırma konusunun tespit ve teşekkülünde 6, 7, 8, 9, 10, 12, 13, 16, 18, 19, 21, 23, 24, 25, 26, 27, 28, 30, 31, 32, 33, 34, 35 numaralı Kırşehir Şer’iyye Sicillerinde bulunan mukavele, senet, satış, vakfiye, vekâlet, kefalet, vesayet, veraset, ıtk, borçlanma, tereke/taksim, evlenme, boşanma, itaat gibi dava tutanaklarından yararlanılmıştır. Ayrıca İslam hukukunun ayrıntılarını anlaşılır kılabilmek için çağdaş kaynaklardan da istifade edilmiştir.
İSTATİSTİKLER IŞIĞINDA YAŞLI BAKIM HİZMETLERİ ALANINDA ÜLKEMİZDE UYGULANAN POLİTİKALAR
Authors: SAKAR Zeynep Müjde
Published: March 2023

Bu çalışma ile ülkemizde gerçekleştirilen yaşlı bakımıyla ilgili gelişmeler ele alınmıştır. Yaşlı bakımının dönem içerisinde geçirdiği değişim vurgulanmaya çalışılmış ve çekirdek aile, köyden kente göç gibi olguların üzerinde durularak yaşlı bakımıyla ilişkilendirilmiştir.

Çalışmamızın öznesi olan “yaşlı bakımı” konusunda Cumhuriyetin ilk yıllarında çalışmalar yeterli ölçüde değildir. Yaşlı bakımıyla ilgili çalışmalar genel manada yerel bir özellik taşıyordu. Bu dönemde Genellikle belediyeler üzerinden yürütülmeye çalışılan sistem önemli ölçüde ihtiyacı karşılayamamıştır. İhtiyacı karşılama konusunda bir takım sıkıntıların çıkmasıyla bu alanda önemli çalışmalar yapıldı Öyle ki 1960’larla birlikte hız kazanacak olan çalışmalar bugünün şekillenmesin de etkili olacaktı.

Özellikle 1961 Anayasası’nda sosyal devletten bahsedilmesi ve 1963’te Sosyal Hizmetler Genel Müdürlüğünün kurulması bu yolda atılan önemli adımlar arasındadır. Ayrıca planlı kalkınma döneminin başlaması ve konumuzla ilgili bir takım çalışmaların üzerinde durulması gelişimin hızlanmasını sağlamıştır. Bütün bunların yanında 2828 sayılı Sosyal Hizmetler ve Çocuk Esirgeme Kurumu Kanunu’nun kabul edilmesiyle ciddi anlamda mesafe alınmıştır. Son dönemde yapılan evde bakım hizmeti çalışmaları, destekleyici bakım hizmeti ve yaşlı yaşam evi gibi uygulamalar bu konuda ne kadar ilerlediğimizin bir kanıtı niteliğindedir
Socio-Political Telegram Channels Reporter and Lentach as New Media
Authors: Solomin Valentin , Karev Nikita
Published: March 2023

The article describes new digital mass media that engage users in content creation and distribution. The research covered the content published in Telegram channels Reporter and Lentach between November 29 and December 12, 2021. The analysis revealed such properties of new media as interactivity, hypertextuality, convergence, digital content, and media environment. The channels use the Telegram platform to interact with readers. They cover the entire range of socially significant topics in typical journalistic genres. However, Reporter specializes in a qualitative analysis of socially significant topics, while Lentach reflects the event agenda in an ironic and sarcastic manner. The research prospects have two main tasks: 1) to identify the optimal forms of formation and promotion of content for messengers and social networks; 2) to develop models of interaction with the audience. The results of the study can be applied by media community workers, media analysts, and new media researchers.
Intentional Precedent Phenomena in Internet Media
Authors: Ragimova Farida
Published: March 2023

This article introduces the phenomenon of intentionality in media texts with a precedent phenomenon in the headline. The author studied the way intentionality develops, functions, and structures itself. Journalists often incorporate precedent phenomena into the media text to demonstrate their intention and creativity. However, the intentional nature of online texts is a major text-forming feature that makes the sender choose particular linguistic means to affect the addressee. The intentional potential of using precedents from different subject areas in media texts showed the following trends: the corpus of precedents expands, and precedent units redistribute themselves relative to the core and periphery.
Segments and Subclasses of Pseudo-Borrowed Onyms in the German Literary Language
Authors: Volkova A. B. , Kobenko Yu. V.
Published: March 2023

The article describes a system-structural analysis of 311 German pseudo-borrowings. The research objective was to classify pseudo-borrowed onyms in the German literary language as pseudo-borrowings or proper names. Pseudo-borrowed onyms are different from assimilates, erratives, pseudomotives, homeonims, memorative fictionyms, and pseudo-Latin cognomens. The sampling was based on six criteria: 1) the onyms developed from a morpheme of the donor language; 2) they violate the principle of reversibility; 3) they belong to the category of  nomina propria ; 4) they are capitalized; 5) they belong to the German language; 6) they imitate a foreign language. German pseudo-borrowed onyms are represented by fourteen segments, the largest of which are the Maccaronian (Common Romanian) segments of pseudo-Latinisms (88 units, 28.3 %) and pseudo-Italianisms (80 units, 25.7 %). The largest onymic subclasses are represented by anthroponyms in the subset of realonyms (36 units, 11.6 %) and fictionyms (149 units, 47.9 %), as well as pragmonyms in the pseudo-Italian segment (70 units, 22.5 %). Fictionyms (166 units, 53 %) dominate over realonyms and come from translated fiction. Pseudo-borrowed onyms differ from appellants in their word formation because they are not tied to prestigious donor languages. The hybrid specificity of pseudo-borrowed onyms make it impossible to localize them as onymic or appellative.
High-sensitivity Troponin (hs-Tn) for Cardiovascular Risk
Prognostication: A Systematic Review and Meta-analysis
Authors: Sagris Marios , Antonopoulos Alexios S. , Angelopoulos Andreas , Papanikolaou Paraskevi , Simantiris Spyridon , Vamvakaris Constantinos , Koumpoura Alkmini , Farmaki Maria , Antoniades Charalambos , Tsioufis Constantinos , Tousoulis Dimitris
Published: March 2023

Background:

Chronic low-grade inflammation is involved in coronary atherosclerosis
progression whereas recent research efforts suggest that preventative methods should be
tailored to the “residual inflammatory risk”. As such, modalities for the early identification of
the risk have to be investigated.

Methods:

We performed a systematic review and meta-analysis according to the PRISMA
guidelines. Any study that presented the prognostic value of high sensitivity troponin (hs-cTn)
of vascular inflammation in stable patients without known cardiac heart disease was considered
to be potentially eligible. The Medline (PubMed) database was searched up to April 22,
2021. The main endpoint was the difference in c-index (Δ[c-index]) with the use of hs-cTn
for major adverse cardiovascular events (MACEs), cardiovascular and all-cause mortality.
We calculated I2 to test heterogeneity.

Results:

In total, 44 studies and 112,288 stable patients without known coronary heart disease
were included in this meta-analysis. The mean follow-up duration of the whole cohort was 6.8
± 1.1 years. 77,004 (68.5%) of the patients presented at low cardiovascular risk while 35,284
(31.5%) in high. The overall pooled estimate of Δ[c-index] for MACE was 1.4% (95%CI:
0.7-2.1, I2=0%) and for cardiovascular death 1.3% (95%CI: 0.3-2.3, I2=0%). Finally, the overall
pooled estimate of Δ[c-index] for all-cause mortality was 3% (95%CI: 1.9-3.9, I2=86%),
while high heterogeneity was observed between the studies.

Conclusion:

The predictive usefulness of changes in hs-cTn measures in stable individuals
with either high or low cardiovascular risk, demonstrates that assessing vascular inflammation
in addition to clinical risk factors enhances risk prediction for cardiovascular events and allcause
mortality. Further prospective studies are necessary to confirm these findings and assist
clinical decision-making regarding the most optimal prevention strategy.
Individual and Combined Antifungal Activities of Artemisia herba alba and
Ammoides verticillata Essential Oils against the Three Main Pathogenic
Microorganisms of Potato
Authors: Medjahed Ilyas Moubarek , Benyelles Nassira Gaouar , Senouci Hanane , Gaouar Manel Yadi
Published: March 2023

Background:

Potatoes are extremely important compared to other vegetable crops. Several species of fungi cause severe damage to different components of the plant (leaves, stems, and tubers), leading to significant losses during cultivation and even after harvest. In the framework of the investigation for alternative methods against the proliferation of these fungi, the present work focuses on the study of the antifungal effect of essential oils of some plants that could be used to solve these problems without the use of harmful chemical substances.

Aim and Purpose:

This study aims to discuss the chemical composition of essential oils of Artemisia herba alba and Ammoides verticillata and evaluate their in vitro and in vivo antifungal activities in order to prevent fungal diseases of potatoes and replace chemical pesticides that cause neurodegenerative diseases.

Methods::

Essential oils extracted from the aerial parts of the plants Artemesia herba alba and Ammoides verticillata were analyzed by gas chromatography-mass spectrometry (GC/MS) and tested individually and in combination for their antifungal effects against Fusarium solani, Penicillium expansum, and Aspergillus flavus, by the radial growth technique.

Results:

The essential oil of A. herba alba was mainly composed of hydrocarbon monoterpenes (80.8%), while the oil of A. verticillata was mainly composed of oxygenated monoterpenes (54.4%). The study on the antifungal effect of essential oils in vitro showed that essential oil of A. Verticillata was more effective against P. expansum (64.40%) than A. flovus (41.10%) and F. solani (53.30%), and the oil of A.herba alba was more effective against A. flavus (54.40%) and (42%) F. Solani. While the combination of these two essential oils of A. verticillata and A. herba-alba gave excellent results, i.e., 100% against P. expansum and A. flavus and 94.40% against F. solani and provided an in vivo protection to the potato in the range of 80% to 90% against the three fungi.

Conclusion:

A. herba alba and A. verticillata individual and combined essential oils are very effective antifungal biocides that can be used as an alternative to chemical pesticides to prevent their harmful effects on health.