bluuebunny/crossref_metadata_2025 huggingface dataset:
Diagnostic value of serum pentraxin-3 in deep vein thrombosis disease
Authors: Erol Yasin , Aygun Ali , Demir Selim , Mentese Ahmet , Mentese Umit , Gunduz Abdulkadir
Published: February 2023

Aim: We investigated the diagnostic value of Pentraxin 3 (PTX-3), a marker that increases in vascular and inflammatory pathologies, in patients admitted to hospital with deep vein thrombosis clinic.
Materials and Methods: 44 patients admitted to the a tertiary medical faculty hospital and a tertiary training and research hospital, with suspect of deep vein thrombosis included in our study. Patients confirmed to have DVT by doppler ultrasonography named as DVT(+) group, and patients not confirmed to have DVT by doppler ultrasonography named as DVT (-). PTX-3 levels determined in blood samples and compared between these groups.
Results: Median levels of D-dimer in DVT(+) group was 3.92 μg/ml (1.57- 6.05), and in DVT (-) group was 1.47 μg/ml (0.97-2.37), and a statistically significant difference was found between these groups (p<0.05). Median levels of Pentraxin-3 in DVT(+) group was 0.42 (0.36-0.49) μg/ml, and in DVT(-) group 0.40 (0.37-0.49) μg/ml, and there was no significant difference found between these groups (p˃0.05).
Conclusion: According to our study, PTX-3 is not a suitable diagnostic marker for the diagnosis of deep vein thrombosis. We think that the value of PTX-3 in the diagnosis of deep vein thrombosis now need to be confirmed with broader, controlled studies.
Preparing reports in cases with blunt trauma to the heart area: Three cases
Authors: Teke Hacer , Balci Yasemin
Published: February 2023

This case series has been prepared to create a perspective to evaluate blunt heart trauma, in which physical and psychological effects of trauma are seen together, in clinical forensic medicine practices. Case 1:A-50-year-old female patient with a history of hypertension had a heart attack in the first 24 hours after blunt trauma, she had an angiography and a coronary stent inserted. Case 2: A 60-year-old woman with no known disease fell after one of the children who entered her garden without permission kicked her ; she had angiography within 24 hours due to chest pain and stenocardia and found that she had coronary heart disease. Case 3: A 60-year-old man with a history of atherosclerotic heart disease had argued with neighbours and had a blow to his chest; in the emergency service, hospitalization was recommended to the patient due to left bundle branch block and troponin results; However, he refused hospitalization and left the hospital. Forensic medical evaluation of heart attack and rhythm disorders after blunt chest trauma or arguments is an important issue. Medical evaluation in terms of heart damage following blunt chest traumas is one of the factors that contribute to forensic reports prepared after the incident.
Thermal tolerance of Cronobacter sakazakii and Cronobacter pulveris in reconstituted infant milk formula
Authors: Garbaj Aboubaker , Farag Samira , Sherif Jihan , Lawila Aml , Eshamah Hanan , Azwai Salah , Gammoudi Fatim , Naas Hesham , Salabi Allaaeddin , Eldaghayes Ibrahim
Published: February 2023

Background: Cronobacter species is the most significant foodborne pathogens in infant milk formula (IMF). These pathogens have been incriminated in sever form of neonatal meningitis, sepsis and necrotizing enterocolitis with high mortality rate.
Aim: The current study was performed to demonstrate the effect of heat stress on Cronobacter spp. (C. sakazakii and C. pulveris) in reconstituted IMF (RIMF).
Methods: The reconstituted formula was inoculated with five C. sakazakii isolates and four C. pulveris isolates separately. The nine isolates of Cronobacter spp. were heated in RIMF at 48, 52, 56, 60, 64 and 66°C. The D- and z-values were determined by using linear regression analysis.
Results: The D˗values of all isolates of C. sakazakii (CS1, CS3, CS4, CS5 and CS6) at 48°C, 52°C, 56°C, 60°C, 64°C, 66°C ranged from 7.29 ˗ 23.47, 2.77˗15.50, 0.62˗1.04, 0.62˗1.02, 0.62˗1.00, 0.62˗1.00 min, respectively, while the z˗ values extended from 2.50˗4.28°C. The D˗ values of C. pulveris isolates (CP1, CP2, CP3, CP4) ranged from 7.60 ˗ 22.32, 1.42 ˗ 8.45, 0.62 ˗ 1.08, 0.62 ˗ 0.78, 0.62 ˗ 0.78, 0.62 ˗ 0.79 min. at 48°C, 52°C, 56°C, 60°C, 64°C, 66°C, respectively and the calculated z-values ranged from 3.33 ˗ 4.89°C.
Conclusion: This study may contribute to improve the understanding of behavior of C. sakazakii and C. pulveris isolates in RIMF at various heat stress temperature and may participate in effective control of this pathogens in infant’s foods production.
Use of a gum elastic bougie in a cat with severe upper airway stenosis
Authors: Kato Keiko , Itami Takaharu , Torisu Shidow , Sakai Toshikazu , Yamashita Kazuto
Published: February 2023

Background: Gum elastic bougie (GEB) is an airway management device for patients who are difficult to intubate and their use has been reported in human medicine. However, to our knowledge, no reports in veterinary medicine have described oxygenation using GEB. We describe a case in which GEB was used to maintain oxygenation in a cat with severe upper airway stenosis.
Case Description: A 10-year-old neutered male domestic shorthair cat was diagnosed with a laryngeal tumour with severe upper airway stenosis. During anaesthesia induction, normal laryngeal structure could not be confirmed; orotracheal intubation was difficult, resulting in a “cannot intubate, cannot oxygenate” status. The GEB was inserted, making it possible to oxygenate the cat until a permanent tracheostoma could be created, but hypoventilation was noted.
Conclusion: Although gum elastic bougies are not useful for proper ventilation, they can be useful for temporary oxygenation in veterinary medicine when airway management is difficult.
Age changes in extramural digestive glands of sheep and rabbits in the postembryonic period
Authors: Zhakiyanova Meiramgul , Seilgazina Saule , Ygiyeva Akerke , Dzhamanova Gulnara , Derbyshev Kamil
Published: February 2023

Background: The study of the peculiarities of the anatomy of sheep and rabbits digestive systems is an important way to improve the efficiency of this animals' breeding.
Aim: The aim of the presented research was to study structural changes of such digestive glands as the liver and the pancreas which occur in the process of ontogenesis in sheep and rabbits.
Methods: Sheep of the “Kazakh fat-tailed semi-coarse-wooled” breed (n=8) raised in the “Sayan” private peasant agriculture and rabbits of the “Grey Giant” breed (n=8), raised on the mini rabbit farm of the Agriculture Faculty of Shakarim University were used in the research
Formed two experimental animal groups (of sheep, “Kazakh fat-tailed semi-coarse-wooled” breed, n=8; rabbits, “Grey Giant” breed, n=8). The liver and pancreas' ontogenesis development has been studied in these animals.
Results: The study presents a holistic view on a macro-microscopic structure of the liver and the pancreas of animals in crucial age periods, stages and phases of postembryonic ontogenesis (by the example of sheep and rabbits). The authors have traced age stages of adaptive change and structural-functional change of stromal-parenchymatous structures of the liver in sheep and rabbits taking into account stages and crucial phases of development.
Conclusion: Development of the liver and the pancreas are characterized by a discontinuous growth in the process of postnatal ontogenesis. A crucially important period is the first months after the birth, during which the weight and functionality of these organs grow rapidly.
Curcuma longa supplementation reduce MDA, TNF-α, and IL-6 levels in a rat model exposed to soot particulates
Authors: Aminuddin Muhammad , Sargowo Djanggan , Sardjono Teguh , Widjiati Widjiati
Published: February 2023

Background: Particulate Matter (PM) is one of the important components in air pollution that can cause endothelial vascular dysfunction through exacerbation of atherosclerosis and inflammation of the respiratory system. Increased levels of MDA in blood plasma can be an indicator of oxidative stress. Then, macrophages can secrete proinflammatory cytokines will stimulate immune cells and vascular endothelial cells to release inflammatory cytokines, such as interleukin-6 (IL-6) and tumor necrotic factor-α (TNF-α). Curcuma longa works by scavenging the active free radicals involved in the peroxidation process.
Aims: This study aims to prove that the administration of Curcuma longa can reduce MDA, TNF-α, and IL-6 levels in Rattus novergicus exposed to soot particulates.
Methods: The subjects of this study were 30 male rats which were divided into 5 treatment groups with the following: (C0): negative control; (C+): positive control; (T1):Treatment group 2, rats exposed to particulate soot at a concentration of 1064 mg/m3 for 8 hours and given Curcuma longa at a dose of 1 mg/kg bw; (T2): Treatment group 3 was rats exposed to soot particulates at a concentration of 1064 mg/m3 for 8 hours and given Curcuma longa at a dose of 2 mg/kg bw; (T3) :Treatment group 4 was rats exposed to soot particulates at a concentration of 1064 mg/m3 for 8 hours and given Curcuma longa at a dose of 3 mg/kg bw.
Giving the Curcuma longa extract orally with a probe every day for 30 days after treatment of exposure to soot. Examination of MDA, TNF-, and IL-6 levels with the ELISA method.
Results: The administration of Curcuma longa can reduce MDA while the lowest MDA levels were obtained in the T3 treatment with an average of 1.542 ± 0.231. The results of the description of the lowest levels of TNF-α were obtained in the C-treatment with an average of 55.981 ± 4.689. Then, the lowest levels of IL-6 were obtained in the C-treatment with an average of 2.292±0.461.
Conclusion: The results stated that the administration of Curcuma longa could reduce MDA levels, TNF-α, and IL-6 levels. Curcuma longa as an anti-inflammatory and anti-oxidant play an effective role in inhibiting inflammation by decreasing IL-6 cytokine and TNF-α. Curcuma longa can inhibit lipid peroxidation initiated by free radicals then reduce MDA levels.
Mites associated with budgerigars Melopsittacus undulatus (Psittaciformes: Psittacidae) and the first report of Ornithonyssus bursa (Mesostigmata: Macronyssidae) in Mexico
Authors: Rejon Julian , Cauich Ingrid , Dzul Julio , Toledo Nohemi , Chim Wilbert , Perez Jose , Viana Karla , Baak Carlos
Published: February 2023

Background: Hematophagous mites affect numerous bird species, causing severe injuries to the budgerigars. Some species can cause dermatitis in humans.
Aims: The purpose was to morphologically identify the mites related to budgerigars (Melopsittacus undulatus) and their nests in Yucatan, Mexico.
Methods: In May 2022, a private budgerigar hatchery was visited and mites were collected from the bodies of the birds and their nests. The morphological traits of the mites were confirmed by scanning electron microscopy.
Results: Four of 30 birds showed severe clinical signs of mite infestation. The Budgerigars revealed lesions in the cere, nostrils, eyelids, beak, and paws. The bird's skin showed signs of dryness and beige colouring. The birds with severe damage also presented anorexia and had deformed paws and beaks. The parasitosis was caused by the "burrowing mites", Knemidocoptes pilae (Lavoipierre and Griffiths, 1951). The burrowing mites and the Grallacheles bakeri (De Leon 1962) were recovered and identified from paw scabs. To eliminate mites, a topical application of Ivermectin was administered to the necks of the birds. The dose was a single, which has a residuality of 21 days. Two drops (0.115mg/ml) of ivermectin were applied to each bird. A gradual reduction in crusted lesions due to mite mortality was noted. The "tropical fowl mite" Ornithonyssus bursa (Berlese, 1888) was identified in the nests, which represent the first record in Mexico.
Conclusions: Three species of mites were discovered in a single budgerigar hatchery. This emphasizes the importance of deworming birds and keeping a clean environment in their cages to reduce the potential for parasitic mite infestation.
Molecular genotyping, histopathological and immunohistochemical studies of bovine papillomatosis
Authors: Gharban Hasanain , Shaeli Sattar , Hussen Talal
Published: February 2023

Background: Bovine papillomatosis (BP) is considered the most common health problem in large cattle farms.
Aim: This study attempts to confirm clinically suspected BP in cattle by PCR assay, histopathology, IHC, and genotyping analysis of local isolates.
Methods: According to morphological appearance and lesion features, a cross sectional study of 54 clinically diagnosed BP cattle was assigned to this current investigation from May to August (2021) in Al-Kut district (Wasit Province, Iraq) private veterinary clinics using purposive sampling technique based on set criteria. The cattle were diagnosed clinically, and the tissues were collected and some fixed in 10% neutral buffered formalin and other stored frozen and examined by histopathological technique, immunohistochemistry, and PCR assays.
Results: Using PCR assay, all cattle were positive for the BPV L1 gene. According to detect the L1 gene, analysis of the phylogenetic tree showed that local BPV cattle isolates were closely related to the NCBI-BLAST BPV type-1 and type-2 of the Polish equine isolate (KF284133.1) and BPV Brazilian Bos taurus isolate (MH187961.1), respectively. Histological detection showed there were acanthosis, hperkeratosis, epidermal thickening, severe infiltration of mononuclear cells, massive hemorrhage, dermal fibroplasia, multifocal spongiosis, moderate neovascularization, moderate to severe elongation of the retention ridge towards the dermis, parakeratosis, rings of calcification, and necrosis with nuclear pyknosis of some spinosum cells. Immunohistochemical findings of tumor necrosis factor-alpha (TNF-), epidermal growth factor receptor (EGFR) and Fascin showed a significant variation in values of immunoreaction in the dermis and epidermis. These results ranged from negative (0) to mild positive (+1) to moderate positive (+2) reactions.
Conclusion: The study provided essential molecular and genotyping data to improve our knowledge by emphasizing the crucial of IHC as an elegant diagnostic method to detect cellular alterations.
Evaluation of efflux pump inhibitory activity of some plant extracts and using them as adjuvants to potentiate the inhibitory activity of some antibiotics against Staphylococcus aureus
Authors: Alsallami Dhama , Alsultan Amjed , Abbas Kadhim , Clarke Simon
Published: February 2023

Background: Antibiotic resistant pathogens became a real global threat for human and animal health. This needs to concentrate the efforts to minimise and control these organisms. Efflux pumps are considered as one of the important strategies used by bacteria to exclude the harm materials out of the cell. Inhibition of these pumps can be an active strategy against multidrug resistance (MDR) pathogens. There are two source of efflux pump inhibitors can be used, chemical and natural inhibitors. The chemical origin efflux pump inhibitors have many toxic side effects while the natural origin characterized by a wide margin of safety for the host cell.
Aim: In this study the ability of some plant extracts like (propolis show rosemary, clove, capsaicin and cumin) to potentiate the inhibitory activity of some antibiotics as (ciprofloxacin, erythromycin, gentamycin, tetracycline and ampicillin) against S. aureus pathogen were tested.
Methods: Efflux pump inhibitory activity of the selected plant extracts were tested using ethidium bromide accumulation assay.
Results: The results have shown that Propolis has a significant synergistic effect in combination with ciprofloxacin, erythromycin and gentamycin. While, it has no effect with tetracycline or ampicillin. Also, no synergic effect was noticed in combination of the MIC for the selected plant extracts (rosemary, clove, capsaicin and cumin) with any of the tested antibiotics. Interestingly, according to the results of EtBr accumulation assay, Propolis has potent inhibitory activity against S. aureus (MRS usa300) pump system.
Conclusion: This study suggests that Propolis might act as a resistance breaker that is able to restore the activity of ciprofloxacin, erythromycin and gentamycin against S. aureus strains, in case of the Efflux-mediated antimicrobial resistance mechanisms.
Methanol extract of Black soldier fly (Hermetia illucens) prepupae against Aeromonas and Staphylococcus aureus bacteria in vitro and in silico
Authors: Qosimah Dahliatul , Santosa Sanarto , Maftuch Maftuch , Khotimah Husnul , Fitri Loeki , am Aulanni , Suwanti Lucia
Published: February 2023

Background: Staphylococcus and Aeromonas bacteria are pathogens in humans and animals. The therapy disrupts the virulence structure of the bacteria, resulting in bacterial death. Currently, chemical drugs have resulted in many resistant bacteria, so it is necessary to find alternative natural materials that are not toxic and do not quickly induce resistance.
Aims: This study aimed to analyze the potential of methanol extract from BSF prepupa as an antibacterial agent against S. aureus and Aeromonas through in silico and in vitro tests.
Methods: The BSF prepupae methanol extract was then analyzed for protein and fatty acid contents. Molecular docking of the active ingredients (defensin, chitin, and chitosan as well as fatty acids) in BSF was downloaded from the NCBI database and docked with the Hex Cuda 8.0 program, Correlation type parameters Shape + Electro and Grid Dimension 0.6. Docking results were analyzed using the Discovery Studio program version 21.1.1.
Results: The highest fatty acid contents in the extract were palmitic acid and myristic acid. Methanol extract from BSF prepupae acted as a bactericidal agent against S. aureus at a concentration of 320 mg/ml, in contrast to Aeromonas, which still showed bacterial growth. The results of the in silico test showed that defensin–aerolysin and defensin–hemolysin were bound to the same active site area. However, the amount of binding energy produced by 69-Defensin-83-aerolysin was higher than all defensin types in BSF against Aeromonas. Chitin and chitosan showed a bond on the active site of aerolysin and hemolysin, but chitosan had a stronger bond than chitin. In silico study also showed the strongest binding affinity of BSF fatty acids to isoleucyl-tRNA synthetase of S. aureus.
Conclusion: The study showed that methanol extract from BSF prepupae had more potential as an antibacterial agent against S. aureus than Aeromonas in vitro and in silico.
Clinicopathological study of sarcomatoid renal cell carcinoma in animals in East Java, Indonesia, from 2017 to 2022
Authors: Prakoso Yos , Widyarini Sitarina , Faresy Fradika , Utomo Yudha
Published: February 2023

Background: Renal cell carcinoma (RCC) is common cancer derived from the renal epithelium. One of the rarest cases of RCC is sarcomatoid RCC (sRCC). The occurrence of sRCC in animals is not clearly demonstrated.
Aim: This study aimed to observe the clinicopathological characteristics of sRCC in animals from East Java, Indonesia, from 2017 to 2022.
Methods: This study used patients which were histopathologically diagnosed with sRCC in our laboratory from 2017 to 2022. The data of clinical characteristics of animals, hematology, serology, histopathology, and immunohistochemistry were retrieved and tabulated. The data was qualitatively and quantitatively analyzed using a simple descriptive method and SPSS version 26, respectively.
Results: Fourteen cases of sRCC in animals have been identified in this study. It was found in rodents, dogs, and cats. sRCC predominantly occurred in rodents (57.14%) without specific clinical signs. The common histopathological findings of sRCC were epithelial renal cells transition into elongated atypical spindle cells. In addition, other histopathological patterns of a renal epithelial cell such as clear cell, tubule-cystic, and papillary also have been found. Immunohistochemistry by using antibodies demonstrates that PAX8 is expressed on sRCC tissue samples 92.85% (13/14 samples). Hence, PAX8 could be used as a supporting method for establishing the diagnosis of sRCC in animals. Hematology and serological tests did not correlate to type of sRCC either pure sRCC or dedifferentiated sRCC. sRCC result in hypercreatinemia in rodents and dogs.
Conclusions: This study shows that the incidence of sRCC in animals is rare. Animals with sRCC did not show any specific clinical signs. The histopathological finding is quite difficult to be differentiated from the other RCC. PAX8 expression on renal tissue samples is useful in supporting the diagnosis of sRCC in animals.
Vitamin D ameliorates liver pathology in mice caused by exposure to endocrine disruptor bisphenol A
Authors: Griw Mohamed , Zaed Suhila , Hdud Ismail , Shaibi Taher
Published: February 2023

Background: Increasing evidence suggests that bisphenol A (BPA) induces liver pathological changes. Further, an association between BPA and circulating vitamin D (VitD) levels were documented.
Aim: The role of VitD in BPA-induced liver pathological changes was explored in this study.
Methods: Healthy 4.5-week-old male (n=35) and female (n=35) Swiss albino mice were used in this study. The animals were randomly divided into control and treated groups. The control groups were further divided into sham (no treatment) and vehicle (corn oil), whereas the treated groups were also divided into VitD (2195U/kg), BPA (50μg/kg), and BPA+VitD (50μg/kg+2195U/kg) groups. For six weeks (twice a week), the animals were dosed intraperitoneally (IP). One week later (at 10.5-weeks-old), the animals were sacrificed for biochemical and histological analyses.
Results: BPA produced a considerable rise in the body and liver weights in both genders of mice when compared to control mice. BPA also caused significant increases in the liver damage markers alanine transaminase (ALT), alkaline phosphatase (ALP), and gamma-glutamyl transferase (GGT). It also induced liver histopathological changes, including higher apoptotic indices in both genders. On the other hand, treatment with VitD considerably reduced liver damage and slightly decreased the apoptotic index rate. The ALP, ALT, and GGT levels were also markedly reduced. VitD has been proven to have a protective effect on both genders.
Conclusions: According to our findings, VitD protects mice from BPA-induced liver damage, possibly via suppressing liver damage markers.
Detection of antibodies to avian leukosis virus in commercial poultry farms in Kaduna State, Northwestern Nigeria
Authors: Bitrus Inuwa , Yiltawe Wungak , Fakilahyel Amina , Ibrahim Amina , Oyekan Olumuyiwa , Hussaini Ularamu
Published: February 2023

Objective: Since 100 years ago, the avian leukosis virus (ALV) was discovered but has remained a threat to poultry production globally, inducing neoplastic diseases of different pathotypes, immu¬nosuppression, growth retardation, and a drop in egg production, thereby resulting in great eco¬nomic losses for both commercial and local poultry farmers. This study investigates the status of the ALV in commercial poultry farms in Kaduna State, Nigeria.
Materials and Methods: Two hundred and fifty sera samples were collected across five local governments in Kaduna State, Nigeria, between January 2017 and May 2018: Chikun, Lere, Kaduna North, Kaduna South, and Sabon Gari and were screened for ALV using the enzyme-linked immu¬nosorbent assay.
Results: A total prevalence of 78.9% (CI: 73.4–83.53) was recorded. The highest prevalence of 82% (CI: 69.53–90.85) was recorded in a commercial poultry farm in Sabon-gari; 80% (CI: 67.24– 89.37), 78% (CI: 64.99–87.85), 78% (CI: 64.99–87.85), and 76% (CI: 62.77–86.3) were recorded for Kaduna North, Lere, Kaduna South, and Chikun commercial poultry farms. For layers, cockerels, and broilers, the detection rate was 86.5% (CI: 79.99–91.58), 75.0% (CI: 24.23–98.75), and 69.6% (CI: 60.66–77.62). At the age level, the highest rate was recorded in older birds, with 86.7% (CI: 74.32–94.41), while 77.1% (CI: 70.7–82.44) was recorded for the young birds, with no significant difference (p > 0.05) between the two age groups.
Conclusion: The study indicated that ALV is prevalent in commercial poultry farms in Kaduna State, Nigeria. It was recommended that further studies be conducted on the molecular charac¬terization of the virus. Adequate preventive and control measures must be implemented because the economic impact of ALV on the poultry industry is enormous.
DESAFIOS DO PROCESSO DE ALFABETIZAÇÃO EM TEMPOS DE PANDEMIA
Authors: Aragão Manoel Soares de , Klein Michele Andreia
Published: February 2023

No Brasil por causa da pandemia as escolas foram fechadas e medidas alternativas de continuação do ensino foram iniciadas. O objetivo do trabalho é realizar um levantamento bibliográfico do impacto que o covid-19 proporcionou nas crianças em processo de alfabetização e letramento, pais e professores e as principais dificuldades encontradas e com isso fazer algumas indagações. A metodologia utilizada foi de uma pesquisa bibliográfica exploratória de enfoque qualitativo. Utilizou-se como base de dados o portal da CAPES selecionando artigos de janeiro de 2020 a março de 2022 com pesquisa realizada no dia 20/03/2022. A primeira fase da filtragem foi a exclusão dos artigos repetidos e a segunda etapa foi a leitura do título e averiguação se está de acordo com o tema. Após essas seleções, foi realizada a leitura de todos e separados 10 artigos científicos, realizando-se uma síntese de acordo com o objetivo. As dificuldades encontradas foram enormes, porém novamente as maiores dificuldades ficaram a mercê de crianças e famílias mais pobres. Porém, também mostrou-se uma resiliência por parte de mães e educadores na busca da continuação dos estudos. O real impacto na aprendizagem das crianças ainda não está claro e precisamos buscar mais estudos em cima deste tema. Provavelmente mais trabalhos serão publicados para nos ajudar a entender este contexto com os alunos, já com as aulas presenciais, porém o que realmente foi deixado claro, foi que houve um aumento da desigualdade educacional durante a pandemia e a necessidade de maiores investimentos na educação pública no Brasil.
A AUTONOMIA DOS RAMOS JURÍDICOS E O DIREITO DO AGRONEGÓCIO: REFLEXÕES A PARTIR DA TEORIA DO CONSTRUTIVISMO LÓGICO-SEMÂNTICO
Authors: Schmidt Vinícius Pomar , Novais Fabrício Muraro
Published: February 2023

O presente trabalho possui como tema, em sentido mais amplo, a questão da divisão do Direito em ramos especializados, assunto que, em tempos atuais, tem-se mostrado cada vez mais suscetível de estudo, devido à proliferação de variadas propostas de criação de disciplinas jurídicas supostamente autônomas. O recorte temático é feito por meio do Direito do Agronegócio, o qual tem ganhado enorme destaque no quadro jurídico nacional, diante, notadamente, da importância desta atividade econômica para os rumos da nação. Questiona-se, pois, qual o melhor modo de posicionar o Direito do Agronegócio dentro do Direito nacional; se seria ele um ramo jurídico autônomo, ou não. Existem várias perspectivas possíveis de serem adotadas para solucionar o problema proposto, mas será utilizada uma teoria de base, a teoria do Construtivismo lógico-semântico, da qual se pretende extrair possíveis respostas. Por isso que, para este artigo, o método dedutivo se apresenta como caminho mais razoável e eficiente. O intuito é verificar, portanto, quais as contribuições que tal teoria pode dar ao tema da divisão do Direito, para que, depois do confronto de hipóteses, possa-se chegar à melhor saída quanto à autonomia, ou não, do chamado Direito do Agronegócio.
EVOLUÇÃO DO TRANSTORNO DO ESPECTRO AUTISTA EM CRIANÇAS ASSOCIADA A PRÁTICA DE EXERCÍCIO FÍSICO
Authors: Sobrinho Isadora Trindade , Roza Isadora Fonseca Santa , Dantas Ana Margarida Carvalho de Oliveira , Cavalcanti Maria Eduarda César Nunes , Graca Raquel Torres da , Fermiano Paula Zanforlin
Published: February 2023

O transtorno do espectro autista (TEA) é caracterizado por um transtorno do neurodesenvolvimento, que compromete o desenvolvimento cognitivo, social e linguístico. Dados da Organização Mundial da Saúde confirmam que 1 a cada 160 crianças vão ter TEA. O exercício físico (EF) é imprescindível para saúde e bem estar de qualquer indivíduo, e cada vez mais está sendo introduzido nas terapias de desenvolvimento de portadores de TEA.
SAÚDE MENTAL DO TRABALHADOR E O ALTO CUSTO DA ASSISTÊNCIA MÉDICA: UMA ANÁLISE POR MEIO DO APRENDIZADO DE MÁQUINA
Authors: Seleme Ana Luísa Gonçalves Gomes Coelho , Cubas João Mário , Carvalho Deborah Ribeiro
Published: February 2023

Objetivo: Identificar variáveis de saúde mental do trabalhador relacionadas ao alto custo nos planos de saúde, por meio do aprendizado de máquina. Método: Pesquisa quantitativa, retrospectiva e de caráter descritivo, com dados administrativos de demandas por procedimentos de saúde de janeiro de 2019 a março de 2021, e de questionário de saúde, aplicado em outubro de 2020, de 586 trabalhadores, assistidos por um plano de saúde. A pesquisa compreendeu quatro etapas: (i) pré-processamento das bases de dados; (ii) construção do modelo com uso do algoritmo random forest; (iii) avaliação das variáveis preditoras, com base no método de importância de Gini; (iv) avaliação dos resultados por especialistas em gestão de saúde. Resultados: Variáveis relacionadas aos transtornos mentais: transtorno bipolar, uso de bebida alcoólica, ansiedade e depressão, foram identificadas como preditoras de casos de alto custo: transtorno bipolar, uso de bebida alcoólica, ansiedade e depressão aos casos de alto custo. Houve concordância dos especialistas quanto a relação destas variáveis com o desfecho alto custo. Considerações finais: Apoiar iniciativas de saúde nas empresas pode promover mudanças que impactam não somente na saúde dos trabalhadores, mas também na produtividade e resultados das organizações, ampliando a atuação de ambulatórios e de gestores de saúde ocupacional.
INCORPORATION AND RELEASE OF HAMAMELIS VIRGINIANA IN “SCAFFOLDS” PRECURSOR MATRIX: AN APPROACH WITH THE “THIN PLATE SPLINE” INTERPOLATION METHOD
Authors: Cubiça Thássio Brandão , Ribeiro Raquel de Souza , Gobbi Vinícius Guedes , da Silva Talita Goulart , Pereira Debora Baptista , De Almeida Hellen Regina Oliveira , Mendonça Tiago dos Santos , Mendonça Roberta Helena
Published: February 2023

In recent years, tissue engineering has been developing methodologies to potentialize the regeneration of injured tissues, such as using biomaterials to obtain scaffolds performing the controlled release of drugs. The polymers polyhydroxy butyrate (PHB) and chitosan (CHI) have been used in the production of matrices applied to scaffold production. This study aims to produce and evaluate matrices containing different proportions of PHB and CHI using the compression molding technique. These matrices can form scaffolds after drug incorporation of Hamamelis virginiana (HV).  In order to predict the swelling of the matrices, the Thin Plate Spline Interpolation method (TPSIM) was used to generate three-dimensional data fitted, showing the influence of time and concentration variables on drug absorption. Results show that the percentage of CHI in the samples determines the swelling degree of the matrices. According to scanning electron microscopy analyses, increasing this polymer's quantity modifies the matrix's morphology, making it more heterogeneous. The sample with 50% by weight composition of CHI showed better-swelling results and samples loaded with HV demonstrated drug release ability. Thus, the obtained matrices have great potential to work as scaffolds and drug delivery systems, and therefore, they are promising products for application in tissue engineering.
FAKE NEWS NAS ELEIÇÕES, DIREITO DA PERSONALIDADE E RESPONSABILIDADE
Authors: Guilherme Luiz Antônio Cardoso de Melo , Dias Clara Angélica Gonçalves Cavalcanti , Neto Ubirajara Coelho
Published: February 2023

O uso de informação contendo inverdades ou fatos deturpados, sobretudo, veiculação de notícias falsas ou “fake news”, é um fenômeno que tende a ocasionar ônus diversos a micro ou macro cenários. O presente artigo possui caráter descritivo analítico e busca debater as fake news nas eleições e sua relação ao Direito de Personalidade e de Responsabilidade, à luz da jurisprudência brasileira sobre uso de desinformação e fake news. O estudo se desenvolve a partir da análise dos conceitos do termo Fake News, e sua relação com a desinformação e a evolução da pós-verdade relacionando a tríade ao processo eleitoral, e os impactos que a fake news - desinformação pós-verdade. A seguir, o texto se debruça na análise do Direito à Personalidade e da Dignidade da Pessoa Humana, que são inerentes ao indivíduo e como esses direitos são afetados pelos processos de enfatização das fake news, dentro das perspectivas dos direitos individuais e coletivos ora fundamentados na Constituição. Por fim, o estudo aborda as questões referentes à responsabilidade civil e criminal do indivíduo que efetiva a ação de fabricação ou difusão das fake News, desinformação e promoção do fenômeno da pós-verdade, bem como os impactos causados por tais ações. A luz do que foi trazido no presente podemos então concluir que a proteção aos direitos à personalidade é resguardado em todas as esferas do direito. O uso indiscriminado de desinformação e fake news no processo eleitoral brasileiro, tende a impactar negativamente a ordem democrática, logo os direitos de personalidade, e, portanto, as ações de combate e educação devem ser imputadas e concretas no cotidiano da população, à luz da Constituição, com base na legislação infraconstitucional, na doutrina e na jurisprudência brasileira.
ANÁLISE DO PERFIL EPIDEMIOLÓGICO DE AUTOMEDICAÇÃO DURANTE A PANDEMIA DE COVID-19
Authors: Cunha Carolina Procath , Borges Lorena Lima Martins Silva , Martins Camila Lima
Published: February 2023

Introdução: Mesmo sem a comprovação de eficácia, o aumento do uso de medicamentos para prevenção do COVID- 19 e devido as consequências do isolamento social já vêm sendo relatado no Brasil e no mundo. Dessa forma, o presente estudo objetivou analisar o perfil epidemiológico em relação a automedicação durante a pandemia de COVID-19. Materiais e métodos: Trata-se de uma revisão sistemática da literatura, realizada no período de Fevereiro a Outubro de 2021, por meio de pesquisas na base de dados: Scientific Eletronic Library Online (Scielo) e Google Acadêmico. Os descritores utilizados foram: automedicação, pandemia, COVID-18, perfil epidemiológico, restringindo a pesquisa ao período de pandemia de COVID-19. Após determinação dos critérios restaram 13 artigos para coleta de dados. Resultado: Os artigos analisados evidenciaram a prevalência maior da automedicação entre as mulheres se comparado com os homens. Foram observados também grupos específicos de automedicação, em regiões com o sistema de saúde menos eficaz, presença de crianças no domicílio, religiosidade, universitários e indivíduos com quadros de ansiedade. Conclusão: O aumento da automedicação durante a pandemia de COVID-19 evidencia a necessidade da adoção de medidas eficazes de orientação e prevenção da automedicação em grupos específicos da população.
INCLUSÃO FEMININA NA CADEIA DE SUPRIMENTO (SUPPLY CHAIN): UM ESTUDO DE CASO SOBRE DIVERSIDADE DE GÊNERO
Authors: Ponte Bruna Nobre , Neto João Pinheiro de Barros
Published: February 2023

O debate e a adoção de ações afirmativas que combatem as desigualdades, sejam elas em qual setor for, estão em praticamente todos os tópicos de discussões do dia a dia da sociedade, visando alcançar um mundo mais justo em termos sociais, políticos, econômicos, de gênero, religiosos e no trabalho. Nesse sentido, os movimentos de empoderamento feminino atualmente são muito atuantes sobre a equidade em relação a carreiras nas organizações, mas em buscas rápidas na internet ao procurar por “Lideranças femininas” evidencia-se que os conteúdos se referem à baixa porcentagem de mulheres em cargos de gestão e liderança. Algumas áreas organizacionais são ainda muito masculinas, a exemplo da cadeia de suprimentos (supply chain). Esta pesquisa trata de um estudo de caso exploratório que objetivou identificar os motivos pelos quais a presença feminina é reduzida nesse setor. O estudo indica que há necessidade de ações afirmativas para estimular mais mulheres a ingressarem na área de supply chain e de maior divulgação das atividades dessa área dentro e fora das empresas de modo a alcançar o público feminino ainda nas instituições de ensino, de forma que direcionem suas carreiras para essa importante área das organizações. A limitação desta pesquisa é o fato de se tratar de um estudo de caso único, que visa explorar o assunto e levantar algumas hipóteses, portanto, sugere-se a realização de outros estudos abrangendo mais empresas com amostra estatística visando obter resultados generalizáveis.
SEQUÊNCIA DIDÁTICA INTERDISCIPLINAR COM FOCO NAS COMPETÊNCIAS TÉCNICAS E HABILIDADES SOCIAIS UTILIZANDO ABP
Authors: Magalhães Daniel Franz Reich
Published: February 2023

Este trabalho apresenta uma sequência didática interdisciplinar através de um projeto de práticas de ensino na área de segurança, meio-ambiente e saúde para estudantes de um curso profissionalizante da rede federal, que dialoga com os objetivos gerais, específicos e competências definidas para o egresso do curso técnico em automação industrial, conforme projeto pedagógico do curso. Este projeto teve como foco a formação técnica, mas também humana, explicitando a necessidade de desenvolvimento das habilidades sociais, tais como liderança, trabalho em equipe, comunicação assertiva, responsabilidade, criatividade. Observou-se que no desenvolvimento do projeto, o ensino em formato de projetos interdisciplinares possibilita uma aprendizagem mais significativa, além de potencializar o desenvolvimento das habilidades sociais. Ratificando o caráter qualitativo e interdisciplinar desta pesquisa, este projeto apresentou como diferencial o foco no desenvolvimento de competências técnicas e habilidades sociais em conjunto. A sequência didática interdisciplinar, a partir das metodologias ativas de ensino e aprendizagem, em específico o ensino e a aprendizagem baseada em problemas (ABP), promove maior significado aos conteúdos aprendidos e potencializa as habilidades sociais. A temática de segurança, meio-ambiente e saúde é considerada de extrema importância para a formação profissionalizante e, metodologias diferenciadas de ensino, contribuem para uma comunicação assertiva com os alunos e uma maior contextualização dos assuntos a serem trabalhados com os alunos, evitando a aprendizagem puramente mecânica. Este projeto pode e deve ser continuado em outras temáticas, promovendo maior desenvolvimento técnico e humano, tanto dos alunos como dos docentes.
RECONSTRUÇÃO DA HELICE EM ESTÁGIO ÚNICO COM RETALHO PÓS-AURICULAR BIPEDICULADO E ENXERTO DE CARTILAGEM
Authors: Gomez Pablo Marcelo Vimos , Gazzola Daniel Nardino , Sangalli Marlei , Meneguzzi Karina , Hernandez Stefany Goudzenko , Duarte Felipe Oliveira
Published: February 2023

Introdução: A reconstrução de defeitos condro cutáneos de orelha após trauma, excisão tumoral e queimaduras podem ser desafiadores para o cirurgião, aquí apresentamos uma técnica de fácil execução, com resultado estético e funcional satisfatório. Relato do Caso: Os autores descrevem o caso de um paciente com defeito do contorno helicoidal após trauma e sua reconstrução cirúrgica tardia com técnica de retalho pós-auricular bipediculado com enxertia da cartilagem ipsilateral num único estágio cirúrgico.
DIABETES MELLITUS TIPO 1 NA INFÂNCIA E APARECIMENTO DE OUTRAS DOENÇAS AUTOIMUNE
Authors: Roza Isadora Fonseca Santa , De Alencar Maria Eduarda Japiassu , Do Nascimento Graciliano Ramos Alencar
Published: February 2023

Diabetes Mellitus tipo 1 (DM1) é compreendido por ser uma doença autoimune crônica que, além da deficiência da produção insulina, afeta o funcionamento dos receptores Toll-Like. Em 2020 foi calculado que cerca de 1,1 milhão de crianças e adolescentes com menos de 20 anos têm DM1. Porém, por a diabetes ser uma doença sistémica, o decaimento do estado geral de saúde e estresse pode levar ao aparecimento de outras doenças autoimunes secundárias.
PENGARUH INDUSTRI KECIL KERAJINAN UMUM DAN INDUSTRI KECIL PENGOLAHAN PANGAN TERHADAP PENYERAPAN TENAGA KERJA SEKTOR INFORMAL DI KABUPATEN WAROPEN
Authors: Waspada Meliala Waspada Meliala
Published: February 2023

Tujuan penelitian ini adalah; untuk mengetahui trend perkembangan jumlah tenaga kerja; peningkatan rata-rata jumlah penyerapan tenaga kerja; tingkat signifikansi pengaruh gabungan, dan parsial dari industri kecil kerajinan umum dan industri kecil pengolahan pangan terhadap penyerapan tenaga kerja sektor informal, di Kabupaten Waropen periode 2008 sampai 2016. Desain penelitian adalah jenis asosiatif atau causal, dengan dua variabel independen dan satu variabel dependen. Variabel independen pertama (X1) adalah industri kecil kerajinan umum, kedua (X2) yaitu industri kecil pengolahan pangan. Variabel dependen (Y) adalah penyerapan tenaga kerja. Hasil penelitian menunjukkan, bahwa trend perkembangan jumlah industri kecil kerajinan umum adalah 66,22 unit setiap tahun, dengan rata-rata peningkatan sebesar 3,32 unit per tahun, dan industri kecil pengolahan pangan adalah 49,67 unit setiap tahun, dengan rata-rata peningkatan sebesar 2,55 unit per tahun; Pengukuran parameter model dengan nilai intercept garis regresi linear majemuk sebesar 0,0476 dengan arah negatif, Koefisien regresi b1 senilai 1,1387 dengan arah positif, dan Nilai koefisien regresi b2 mengindikasikan bahwa untuk setiap kenaikan sebesar satu unit dalam jumlah industri kecil pengolahan pangan bertendensi meningkatkan jumlah tenaga kerja yang dapat diserap kedua jenis industri kecil termaksud rata-rata sebesar  6,17 orang; Nilai koefisien korelasi majemuk yang diperoleh sebesar  0,9956 mengindikasikan adanya korelasi yang sangat tinggi antara kedua variabel independen dengan variabel tak bebasnya; Nilai koefisien korelasi parsial memperlihatkan bahwa dengan mengabaikan tendensi linear salah satu variabel bebas, baik jumlah industri kecil kerajinan umum (r = 0,9995) maupun industri kecil pengolahan pangan (r = 0,9999), secara terpisah memberikan pengaruh parsial yang sangat kuat dan positif terhadap penyerapan tenaga kerja di Kabupaten Waropen.
Teaching English Online Using Video Conferencing: The Challenges to EFL Instructors and Their Solutions
Authors: Nguyen Tat Hiep , Nguyen Thi Ngoc Uyen
Published: February 2023

The purpose of this study is to discover the challenges that English teachers face when teaching online English via video conference. The authors hope to discover some remedies from that to resolve these issues. In this study, the author used qualitative research methodologies to examine the different challenges EFL teachers encounter when instructing English online via video conferencing and how they overcome those difficulties. This investigation aims to become aware of English teachers' challenges when instructing online via video conferences. Also, the authors would like to discover how English teachers use video-conferencing software when teaching online and how they overcome these difficulties. The researcher used interviews and questionnaire techniques to collect data. The same questions from an online interview with ten English teachers were given through a Google form. The first question stated that there were five difficulties that English teachers had to overcome when teaching online: internet connectivity, media, a lack of interaction between students and teachers, low skill, and technical issues. There are four alternative responses to the second research question: role plays are widely used in instructional activities to improve teacher-student engagement, and quiet teaching and learning environments are widely used in instructional activities to increase teacher-student engagement.
WATCHING ATTITUDE FACTORS IN DELIVERING MUKBANG SHOWS
Authors: Styawan Zenyt , Buwana Danang Sangga
Published: February 2023

Mukbang is an opportunity to find sustenance. This research using 8 concepts consisting of attraction in delivery, voyeurism mediation, perceptions of novelty, loneliness, health awareness, collectivity, social normatives and intentions watch. This study uses a positivism paradigm using quantitative approach and survey methods. The population in this study were adolescents age 15 to 17 years old. Based on research results this shows that the normative influence of Tanboy kun loneliness appeal to consciousness health with the collective perception of novelty in mediating voyeurism the delivery of mukbang (X) affects the intention to watch (Y) students of SMKN 1 Bekasi.
THE EFFECT OF LEVERAGE, ACCEPTABLE TURNOVER AND INVENTORY TURNOVER ON COMPANY PROFITABILITY
Authors: Kartika Annisa Dwi , Hertati Lesi , Munandar Aris
Published: February 2023

This study aims to determine the effect of leverage, accounts receivable turnover and inventory turnover on profitability in food and beverage industry companies listed on the IDX for 2019-2021. This research is quantitative in nature. The sample used consisted of 18 companies from a population of 26 food and beverage companies listed on the Indonesian Stock Exchange in 2019-2021. This study makes use of Indonesia Stock Exchange as a secondary data. The method of data analysis employed is panel data regression. The results showed that Profitability is a predictable growth or reduction in annual earnings. Significant profit capability indicates the company's potential to generate high profits, resulting in a rise in dividend payout. Hence, the potential to generate profits will influence the decision of investors to raise their capital investment in the business.
PENGARUH PERTUMBUHAN RASIO KEUANGAN, PENJUALAN DAN DIVIDEN TERHADAP PTP NUSANTARA II KEBUN ARSO KABUPATEN KEEROM
Authors: Heluka Elius
Published: February 2023

Investor membutuhkan beberapa informasi untuk membantu membuat keputusan investasi yang tepat. Penelitian ini bertujuan untuk mengetahui pengaruh kinerja keuangan terhadap keputusan manajemen dalam membayar dividen kepada pemegang saham. Rasio tersebut digunakan untuk penelitian likuiditas, profitabilitas, pertumbuhan penjualan dan dividen implikasinya terhadap harga saham. Di sana pencarian menunjukkan fundamental perusahaan; aspek keuangannya menjadi pertimbangan dan implikasinya pada harga saham. Penelitian ini menggunakan metode egresi linier untuk menganalisis pengaruh profitabilitas, likuiditas, pertumbuhan penjualan dan dividen terhadap harga saham di Bursa Efek Indonesia selama 3 tahun berturut-turut mulai tahun 2013 sampai dengan tahun 2015. Hasil penelitian menunjukkan bahwa profitabilitas berpengaruh terhadap return saham. Sedangkan likuiditas, pertumbuhan dan dividen tidak berpengaruh terhadap harga saham.
PENGARUH KUALITAS LAYANAN TERHADAP KEPUASAN PELANGGAN RUMAH TANGGA PADA PT. PLN (Persero) RAYON JAYAPURA
Authors: Melmambessy Dani
Published: February 2023

Hasil penelitian ini menunjukkan bahwa kualitas layanan berpengaruh terhadap kepuasan pelanggan rumah tangga pada PT. PLN (Persero) Rayon Jayapura dapat terbukti karena hasil nilai t hitung variabel kualitas layanan (X) sebesar 9,976 > nilai t tabel 1,644 dengan tingkat signifikansi sebesar 0,000 < á 0,05. Persamaan regresi dalam penelitian ini yaitu Y = 0,677 + 0,854X yang menunjukkan bahwa nilai konstanta 0,677 yang berarti bahwa apabila tidak memperhitungkan variabel kualitas layanan (X) maka kepuasan pelanggan rumah tangga pada PT. PLN (Persero) Rayon Jayapura sebesar 0,677 dan nilai koefisien regresi (R) sebesar 0,854 menunjukkan bahwa apabila kualitas layanan meningkat sebesar satu maka, akan berpengaruh terhadap meningkatnya kepuasan pelanggan rumah tangga pada PT. PLN (Persero) Rayon Jayapura sebesar 0,854.Nilai koefisien korelasi (R) sebesar 0,712 menunjukkan bahwa terdapat hubungan yang kuat antara kualitas layanan terhadap kepuasan pelanggan rumah tangga pada PT. PLN (Persero) Rayon Jayapura dan nilai koefisien determinasi R² sebesar 0,506 menunjukkan bahwa variabel bebas kualitas layanan (X) mampu mempengaruhi atau menerangkan variabel terikat yaitu kepuasan pelanggan rumah tangga (Y) pada PT. PLN (Persero) Rayon Jayapura sebesar 0,506 atau 50,6% sedangkan sisanya sebesar 0,494 atau 49,4% dipengaruhi oleh variabel lain yang tidak diteliti dalam penelitian ini.