bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of interferon-based therapy with risk of autoimmune diseases in patients with chronic hepatitis C virus infection: A population-based Taiwanese cohort study
Authors: Chou Shu-Ming , Yeh Hsing-Jung , Lin Tzu-Min , Chang Yu-Sheng , Hsu Hui-Ching , Shen Yu-Chuan , Kuo Tzu-Tung , Chen Jin-Hua , Chen Shu-Chuan , Chang Chi-Ching
Published: October 2022

Background

Interferon in combination with ribavirin has been the standard of care for chronic hepatitis C virus infection (HCV) for the past few decades. However, its effect on the risk of autoimmune diseases (ADs) among patients with HCV infection remains unclear. We assessed the potential association between interferon-based therapy (IBT) and AD risk in patients with HCV infection.

Methods

This retrospective cohort study identified patients diagnosed with HCV infection between January 1, 2006, and December 31, 2015, from Taiwan’s National Health Insurance Research Database. In total, 16,029 patients with HCV infection who received IBT and 141,214 patients with HCV infection who did not receive IBT were included. Both cohorts were followed up to assess the development of ADs. Hazard ratios (HRs) were calculated using the Cox proportional hazards regression model, which was adjusted for potential confounders.

Results

The median follow-up period for IBT and non-IBT users was 4.53 and 3.34 years, respectively. No significant difference in the risk of overall ADs (adjusted HR [aHR]: 0.96, 95% confidence interval [CI]: 0.81–1.14) or systemic ADs (aHR: 0.88, 95% CI: 0.71–1.10) was noted during the study period. However, a slight increase in the risk of organ-specific ADs was noted among IBT users (incidence rate ratio: 1.33, 95% CI: 1.02–1.72). Furthermore, analysis of AD subgroups revealed a significant increase in the risks of Graves’ disease (aHR: 6.06, 95% CI: 1.27–28.8) and Hashimoto’s thyroiditis (aHR 1.49, 95% CI 1.01–2.21) among IBT users.

Conclusions

IBT use increases the risk of autoimmune thyroid diseases (Hashimoto’s thyroiditis and Graves’ disease) in patients with HCV infection to a greater extent than non-IBT use.
Extraction efficiency of different microplastic polymers from deep-sea sediments and their quantitative relevance
Authors: Canensi Sara , Barucca Gianni , Corinaldesi Cinzia
Published: October 2022

An increasing number of methods for extracting microplastic particles from marine sediments have been published but without evaluating the extraction efficiency. Furthermore, while most of the procedures developed have been applied to sandy sediments from shallow water habitats, specific and standardized procedures for deep-water sediments (> 200 meters deep) are limited. In this study, we describe a specific protocol for extracting microplastics (2- 1000 µm) from deep-sea sediments and for quantifying and identifying them. We also assessed its extraction efficiency, which resulted in a high recovery (on average ca. 60%, and up to 80%) particularly, for polyethylene, polypropylene, and polystyrene. This method can be applied to all fine-grained/muddy sediments and allows the extraction of even the smallest fraction of microplastics (<20 µm), which are expected to have the most severe effects on marine biodiversity and ecosystem functioning and ultimately also have implications for human health.
Nanotexturing TiO2 over carbon nanotubes for high-energy and high-power density pseudocapacitors in organic electrolytes
Authors: Poirot N. , Rajalingam V. , Murgu R. N. , Omnée R. , Raymundo-Piñero E.
Published: October 2022

Titanium oxides have been considered potential electrode materials for pseudocapacitors because of their exceptional properties, such as high thermal and chemical stabilities, ready availability and low cost. However, they are not ideal for practical applications due to their poor ionic and electrical conductivity. The electrochemical performance of TiO2 can be greatly improved if the material is nanotextured by reducing the particle size in optimizing the synthesis pathway. Actually, for metallic oxides, the electrochemical performance significantly depends on the particle size/morphology. At relatively low current densities the higher capacity values are exhibited by noncrystalline TiO2 having 2 nm particle size, with values reaching 704 C g−1. However, only thin electrodes are able to operate at a high charge density, limiting the energy density of the final device. Here, we propose a solution to circumvent such a drawback by further nanotexturing TiO2 over multiwalled carbon nanotubes (CNTs). For that purpose, CNTs were introduced during oxide preparation. The synthesis protocol has been optimized for obtaining a uniform coverage of small TiO2 particles on the surface of the CNTs. At low current densities, high mass loading TiO2/CNT composites electrodes are able to deliver capacitances as high as 480 F g−1 and the presence of CNTs allows keeping 70% of the capacitance at high current densities while only 27% is retained when using a regular conductivity agent as carbon black. The results demonstrate that uniform nanotexturation of TiO2 over CNTs allows good rate capabilities to be obtained for thick electrodes having sufficient active material loading to achieve high specific energy and power densities.
Bacteria-mediated cancer therapy: A versatile bio-sapper with translational potential
Authors: Luo Miao , Chen Xiaoyu , Gao Haojin , Yang Fan , Chen Jianxiang , Qiao Yiting
Published: October 2022

Bacteria are important symbionts for humans, which sustain substantial influences on our health. Interestingly, some bastrains have been identified to have therapeutic applications, notably for antitumor activity. Thereby, oncologists have developed various therapeutic models and investigated the potential antitumor mechanisms for bacteria-mediated cancer therapy (BCT). Even though BCT has a long history and exhibits remarkable therapeutic efficacy in pre-clinical animal models, its clinical translation still lags and requires further breakthroughs. This review aims to focus on the established strains of therapeutic bacteria and their antitumor mechanisms, including the stimulation of host immune responses, direct cytotoxicity, the interference on cellular signal transduction, extracellular matrix remodeling, neoangiogenesis, and metabolism, as well as vehicles for drug delivery and gene therapy. Moreover, a brief discussion is proposed regarding the important future directions for this fantastic research field of BCT at the end of this review.
SSX addiction in melanoma propagates tumor growth and metastasis
Authors: Traynor Sofie , Ebstrup Malene Laage , Gammelgaard Odd Lilleng , Mansoori Behzad , Terp Mikkel Green , Rein Cecilie Rose Hauge , Rattenborg Sofie , Pedersen Christina Bøg , Ditzel Henrik Jørn , Gjerstorff Morten Frier
Published: October 2022

Cancer/testis antigens are receiving attention as targets for cancer therapy due to their germ- and cancer cell-restricted expression. However, many of these antigens are inconsistently expressed among cancer types and individual tumors. Here, we show that members of the SSX cancer/testis antigen family comprise attractive targets in the majority of melanoma patients, as SSX is expressed in more than 90% of primary melanomas and metastases and plays a critical role in metastatic progression. Accordingly, SSX silencing in melanoma mouse xenograft models reduced tumor growth and completely abolished the formation of metastatic lesions in lungs and livers. Mechanistically, we demonstrate that silencing SSX in melanoma cells induces cell cycle S-phase stalling, leading to proliferative arrest and enhanced apoptosis, which elucidates the inhibitory effect of SSX loss on tumor growth and colonization capacity. Silencing SSX further compromised the capacity of melanoma cells to migrate and invade, influencing these cells’ capability to spread and colonize. Taken together, these studies highlight SSX proteins as pivotal targets in melanoma with implications for blocking metastatic progression.
Chuanzhitongluo capsule ameliorates microcirculatory dysfunction in rats: Efficacy evaluation and metabolic profiles
Authors: Sun Yuanfang , Cheng Guoliang , Du Lijing , Gan Yu , Li Bing , Yan Shikai , Shao Mingguo , Jin Huizi , Li Shasha
Published: October 2022

Background: Ischemic stroke is a leading cause of mortality and disability worldwide. Microcirculatory dysfunction is the foremost hindrance for a good clinical prognosis in ischemic stroke patients. Clinical researches show that Chuanzhitongluo capsule (CZTL) has a curative effect during the recovery period of ischemic stroke, which contributes to a good prognosis. However, it is not known whether CZTL treats ischemic stroke by ameliorating microcirculation dysfunction.

Objective: In this study, we investigated the influence of CZTL on microcirculation and its underlying mechanism.

Methods: A rat model of acute microcirculatory dysfunction was established by stimuli of adrenaline and ice water. The microcirculatory damage in model rats and the efficacy of CZTL were assessed by detecting laser speckle contrast imaging, coagulation function, hemorheology, vasomotor factor and microcirculation function. The potential mechanism of CZTL action was explored by the untargeted metabolomic analysis based on ultra-performance liquid chromatography-quadrupole-time of flight-mass spectrometry.

Results: Laser speckle contrast imaging showed that model rats suffered low perfusion in ears, feet and tails, and CZTL treatment increased microcirculatory blood flow. Coagulation function detection results showed that CZTL diminished the reduction of thrombin time, prothrombin time, activated partial thromboplastin time and the elevated fibrinogen level caused by acute microcirculatory dysfunction. Furthermore, CZTL could recover the increased blood viscosity as well as the abnormal vasomotor and microcirculation function in rats with acute microcirculatory dysfunction. Metabolomics analysis indicated that CZTL might regulate sphingolipid metabolism and arachidonic acid metabolism to exert protective effects on microcirculation.

Conclusion: These results elucidated that CZTL was highly effective against microcirculatory dysfunction and its potential mechanisms related with the modulation of sphingolipid and arachidonic acid metabolic pathways. The present study provided a new perspective on the clinical application of CZTL, and it contribute to explore novel therapeutic drug against microcirculatory dysfunction.
Effectiveness of perampanel in the treatment of pediatric patients with focal epilepsy and ESES: A single-center retrospective study
Authors: Yu Tao , Teng Zi-Teng , Liu Xue-Yan , Wang Hua
Published: October 2022

Objective: To investigate the therapeutic effect and influencing factors of perampanel (PER) on electrical status epilepticus during sleep (ESES).

Methods: We retrospectively analyzed the clinical data of pediatric patients with focal epilepsy and ESES who were treated at the Epilepsy Center of Shengjing Hospital of China Medical University between January 2016 and March 2022. Changes in the spike wave index (SWI) after 24 weeks of PER add-on treatment were compared. Kaplan‒Meier survival analysis, the log-rank test and multivariate Cox regression analysis were performed.

Results: A total of 54 pediatric patients met the inclusion criteria, including 33 males and 21 females. The mean age at the diagnosis of epilepsy was 6.41 ± 2.14 years and at ESES diagnosis was 7.58 ± 2.40 years. The mean ESES duration before add-on PER was 25.31 ± 15.12 months. The mean age of the patients at add-on PER initiation was 9.69 ± 2.12 years. The ESES resolved in 29 children after 6 months of PER add-on treatment, and the response rate was 53.7%. Univariate analysis with the log-rank test showed that the therapeutic effect of PER differed according to the age at ESES diagnosis and ESES duration before add-on PER treatment. Multivariate Cox regression analysis showed that only ESES duration before PER administration was a risk factor for PER treatment failure, and the other factors had no effect on the therapeutic effect.

Conclusion: PER add-on treatment has a good therapeutic effect on ESES and can be used as an alternative to corticosteroid and benzodiazepines. The therapeutic effect of PER add-on treatment was not related to the dose. A longer ESES duration results in a worse therapeutic effect. Therefore, more aggressive treatment measures should be implemented for ESES.
Systematic review of ethnomedicine, phytochemistry, and pharmacology of Cyperi Rhizoma
Authors: Wang Fengyou , Zhang Shihao , Zhang Jiaxu , Yuan Fu
Published: October 2022

Cyperi Rhizoma(CR) is the dry rhizome ofCyperus rotundusL., a Cyperaceae plant. It has a long history of clinical medication and is known as the “holy medicine” of gynecology. CR smells sweet and bitter. It has the effect of soothing the liver and relieving depression, regulating qi, regulating meridian and relieving pain. It can be used to treat liver qi stagnation, chest pain, spleen and stomach qi stagnation, hernia pain, irregular menstruation and other diseases. At present, the main chemical constituents isolated from CR are volatile oil, flavonoids and terpenes. Modern pharmacological studies have shown that CR has a wide range of pharmacological activities, including antidepressant, hypoglycemic, antioxidant, anti-inflammatory, antipyretic and analgesic effects. In this paper, the botany, traditional application, phytochemistry, pharmacological effects, processing and other aspects of CR are reviewed. At the same time, the shortcomings of current research of CR are discussed in depth, and the possible solutions are put forward in order to find a breakthrough point for future research of CR.
Working memory in pre-school children with autism spectrum disorder: An eye-tracking study
Authors: Zacharov Oleg , Huster Rene Jürgen , Kaale Anett
Published: October 2022

Working memory (WM) was examined in pre-school children with Autism spectrum disorder (ASD) and children with typical development using eye-tracking technology. The children were presented with a digital A-not-B task (with a short and a long waiting condition) where they passively viewed animations of a moving train. Moreover, the current study investigated the relationship between non-verbal mental age (NVMA) and the performance on the task. No group differences were found in the average looking durations between the ASD and typically developing (TD) groups on either the short or long waiting conditions. Although the NVMA of the ASD group was lower than that of the TD group there were no correlations between NVMA and task performance in either group. The results suggest that WM in young children with ASD might not be different from that of TD children. However, the results might be due to ceiling effects of the task and thus needs to be further investigated.
Diminished ability to integrate target stimuli with context during emotional recognition in individuals with broad autism phenotype
Authors: Cha Woo-Jin , Lee Jang-Han
Published: October 2022

Individuals with broad autism phenotype (BAP) have a tendency not to integrate emotional stimuli with the surrounding context. They have also shown different patterns and abilities in processing positive and negative emotions. This study aimed to examine whether the effect of context on target stimuli could vary depending on the type of target emotion in individuals with BAP. Based on the Broad Autism Phenotype Questionnaire (BAPQ) and Autism-Spectrum Quotient (AQ), 36 individuals with BAP and 33 healthy controls were selected. All the participants performed an overlap-emotional task consisting of six conditions: 2 (congruence: congruent and incongruent) × 3 (emotion: fearful, sad, and happy). Reaction time and accuracy were measured as dependent variables. The results revealed that the individuals with BAP showed no difference in reaction time between the condition of congruence and incongruence, but that the control group was faster to categorize facial expression on the condition of congruence than that of incongruence regardless of the type of target emotion. There were no differences between the two groups in any of the conditions with regard to accuracy. These findings indicate that individuals with BAP tend not to integrate target emotions with contextual information, a feature that could worsen the speed of emotional recognition in individuals with BAP. This study confirmed that the individuals with BAP have different cognition patterns in emotional recognition than the control group.
Role of employee loneliness, job uncertainty and psychological distress in employee-based brand equity: Mediating role of employee exhaustion
Authors: Chen Hao , Li Jingya , Li Juan , Bao Jiaying
Published: October 2022

Employee-based brand equity plays a crucial role in building organizations' brand equity, and organizations strive to maintain it because of its stimulating effect on competitive achievement. Based on psychological contract and stress theory, this study developed a model that points out the antecedents which can play an adverse role in the EBBE building process. This study explores the role of employee loneliness, job uncertainty, and psychological distress on employee-based brand equity. This study also explores the mediating role of emotional exhaustion in these relationships. For the empirical analyses of the model, this study gathered data based on a 459 sample size under a time-lag approach from the employees of clothing brands in China. This study analyzed the data through partial least square structural equation modeling (PLS-SEM). For this purpose, SmartPLS software was used. The outcomes revealed that employee loneliness has no direct relationship with employee-based brand equity; however, job uncertainty and psychological distress negatively influence employee-based brand equity, such as job uncertainty and psychological distress reduce employee-brand-based equity. Moreover, emotional exhaustion mediates the relationship between employee loneliness and employee-based brand equity and job uncertainty and employee-based brand equity; however, emotional exhaustion does not mediate the relationship between psychological distress and employee-based brand equity. Finally, practical implications, limitations, and future directions are discussed in this study.
Examining distribution patterns of foraging and non-foraging sperm whales in Hawaiian waters using visual and passive acoustic data
Authors: Barkley Yvonne M. , Sakai Taiki , Oleson Erin M. , Franklin Erik C.
Published: October 2022

Following the end of over a century of intensive commercial whaling in 1986, the monitoring and assessment of sperm whale populations is essential for guiding management and conservation decisions for their recovery. Species distribution models (SDMs) are a useful tool for examining and predicting cetacean distribution patterns and typically incorporate visual, ship-based observations. However, understanding sperm whale distribution and habitat use based solely on surface visual observations is challenging due to the significant amount of time sperm whales spend foraging at depth. For the endangered sperm whale population occurring in Hawaiian waters, we used visual and passive acoustic data collected during four annual NOAA marine mammal line-transect surveys and a suite of biologically relevant environmental variables to develop SDMs within a generalized additive modeling framework to study the distribution of sperm whale groups throughout the island chain. Additionally, the passive acoustic data allowed us to differentiate sperm whale groups as foraging or non-foraging based on their click types to account for differences in distribution and behavior within the archipelago. Foraging groups were predicted primarily in the northwestern region of the archipelago between Laysan Island and Pearl and Hermes Reef as well as north of Maui and Hawaiʻi in the main Hawaiian Islands. Non-foraging groups were predicted to be more uniformly distributed throughout the archipelago. Foraging whale models selected temperature at 584 m depth, surface chlorophyll, and location, while the only significant variables for non-foraging whale models included the standard deviation of sea surface height and location. Each variable provides insight into the oceanographic processes influencing prey abundance and, thus, sperm whale foraging behavior. This study furthers our understanding of the distribution patterns for the sperm whale population in Hawaiʻi and contributes methods for building SDMs with visual and passive acoustic data that may be applied to other cetacean species.
FORMATION OF COGNITIVE ACTIVITY IN STUDENTS WITH SPECIAL EDUCATIONAL NEEDS (SEN) DURING RESEARCH WORK IN THE LESSONS OF THE NATURAL CYCLE
Authors: ВARANNIK N. , DYACHENKO-BOGUN M.
Published: October 2022

The article analyzes the importance of research work in the natural sciences in the formation of cognitive activity of students with special educational processes, as well as the organization of the educational process for such children. The essence of inclusive education is revealed. Emphasis is also placed on the fact that in recent years there is a growing need to train teachers and educational institutions to teach children with SEN, development and further improvement of educational and methodological support (individual curricula, special programs, textbooks and teaching aids, taking into account personal requirements). activity approach in education of children with psychophysical development disorders, effective teaching and learning technologies suitable for polymorphic contingent of students), creation of special conditions (availability of buildings and premises, use of appropriate forms and methods of educational work, psychological and pedagogical support, cooperation with parents or persons replacing them, providing a child with special educational needs with psychological and pedagogical correctional assistance). A brief description of the characteristics of children with certain educational needs, which need to pay attention to the teacher in the organization of the educational process. It also describes the need to involve children with SEN in research work in natural sciences that contribute to the understanding of the essence of the world. As a result of such work, students 'cognitive and creative activities are intensified, communication and interaction skills are developed, and it also helps to determine students' career guidance.
FORMATION OF PERSONALITY’S READINESS FOR SUSTAINABLE CONSUMPTION
Authors: BULCHENKO D. , TODOROVA I.
Published: October 2022

The article is devoted to the analysis of meaningful and sustainable consumption as a psychological phenomenon that reflects the current need of society in the formation of personalities’ readiness for the conscious consumption, which is motivated by ecological and social factors. It revealed that today consumption is an important type of human activity through which the formation and manifestation of his personality takes place and the ability to perform an action can be realized. The components and psychological criteria of readiness for sustainable consumption are identified, three levels of readiness for sustainable consumption are characterized, targets and means of forming sustainable consumption are outlined, and the needs for changes in the education system for sustainable consumption and training of practical psychologists to work with consumer behavior are justified.
INTERNATIONAL EXPERIENCE OF THE IMPLEMENTATION OF INCLUSIVE EDUCATION IN THE EUROPEAN COUNTRIES
Authors: GREBA I. , LEVRINTS M.
Published: October 2022

The article analyzes the international experience of legal regulation of inclusive education and its implementation in European countries, including Belgium, Spain, Italy and Germany. The main tendencies in the development of the education systems of European countries are the deepening of its spiritual and cultural components and bolstering of humanistic orientation in the educational process. The present paper highlights the main stages in the development of inclusive education, increased attention to children with special educational needs, and activation of their integration into society, characteristic of some European countries in the 70-the 80s of the XX century. Spurred by the body of specialized academic knowledge about special educational needs, the quality of inclusive education is gradually rising. Joint education and upbringing have become an integral part of European education, though the means of its implementation differ around its countries. In particular, special education institutions have been almost eliminated in Spain, Italy, Greece, and Portugal. Despite the differences in the current types and levels of educational institutions, secondary education in Western Europe is one of the key elements of the modern European model of social organization. For the post-Soviet countries, this system provides a window into ways of attending to pedagogical and social problems that arise alongside the implementation of inclusive education.
EVOLUTION OF IDEAS OF EDUCATION FOR SUSTAINABLE EDUCATION
Authors: ILCHENKO V. , HUZ K.
Published: October 2022

The article deals with the evolution of ideas of education for sustainable development. Special attention is given to the pedagogical technology «Dovkillya» («Environment») as a variant of ESD. The authors analyzed the achievements of the model of education for sustainable development of society and indicate the direction of improvement of the model in accordance with the new standard of education. The areas of activity of the department of integration of the content of general secondary education of the Institute of Pedagogy of the National Academy of Sciences of Ukraine, which together with the Department of Methodology of the Content of Education of the PANO named after M. V. Ostrogradskyi plans to update the educational and methodological support of the model of education for sustainable development «Dovkillya» in accordance with the State Standard of General Secondary Education (2021). «Dovkillya» programs for grades 1-4 have been developed and approved by the Ministry of Education and Culture, educational and methodological support for the «Dovkillya» course for grades 1-6, and a study of its impact on the development of students' verbal and non-verbal intelligence, levels of their social maturity and health is planned, as this was investigated during the implementation of the model of education for sustainable development «Dovkillya».
PSYCHOLOGICAL AND PEDAGOGICAL FEATURES OF SPORTS ACTIVITY OF WATER SPORTS ATHLETES
Authors: KRAVCHENKO I. , FESENKO L. , KRAVCHENKO R.
Published: October 2022

Maintaining and improving the health of the population has always been one of the key issues in society. Today, young people choose a healthy lifestyle and play sports. Sport is one of the typical social models of a person's life struggle for his own place in society, an arena for self-affirmation and public demonstration of one's own active life position. The high level of sporting achievements and competition in water sports makes a number of demands on the physical and mental capabilities of the athlete. The modern development of the system of psychological and pedagogical support for the training of water sports athletes requires clarification of the essence, content and structure of sports activities.The article reflects the psychological features of the activities of athletes in water sports: outlines the nature of the interaction of athletes with sports entities; it is provided that the combined-individual nature of the interaction of swimmers during competitions is provided by the dominant monofrontal mental activity of athletes.
PREPARETION OF FUTURE EDUCATORS FOR AND ETHICAL EDUCATION OF PRESCHOOLERS BY MEANS OF ART
Authors: LARINA I. , DAVYDOVA M. , DOLIA Y.
Published: October 2022

In the times of decline of many indicators of life quality, one of the key problems of our society is the issue of moral education of the younger generation. The state of society, where aggression, conflict, cruelty, war, crime are becoming commonplace, significantly reduces the chances of children for moral and ethical development. Ideals are disappearing, there is no clear idea of what ideals should be. Overcoming this crisis in the life of society and in the lives of individuals is possible only if the revival of the truly spiritual foundations of our society, its morality.

In the process of moral development during preschool childhood, under the influence of adults, the orientation of the individual is formed - the system of motives for behavior. An important role in solving the problem of moral and ethical education of preschoolers belongs to the educator, his professional competence.

One of the most important means of moral and ethical education is art, its varieties (musical, visual, theatrical). Art is an inexhaustible source of various emotions. It contributes to the emergence of children's emotional attitude to the events described in theatrical performances, to the images of music and fine arts, to their own manifestations in the performance of collective creative exercises.

The direct impact on the acquisition of moral values by preschoolers in the process of communicating with art depends entirely on the educator, on his professional competence. The content, methods of teaching, personality and knowledge of the educator, who passes his worldview, culture, moral experience to the next generation, are of decisive importance. All this is a system of influences that guides the personal development of children.

Preparation of future educators for the implementation of moral and ethical education of preschoolers is realized through the introduction into the educational process at the Faculty of Preschool Education of Kharkiv National Pedagogical University named after GS Skovoroda various types of children's creative activities (games, technical and artistic modeling, music); saturation of educational space with practice-oriented situations close to real life.

The use of technology of integration of arts plays an important role in teaching disciplines of aesthetic orientation. This technology provides students with mastery of the means of creative activity and helps to create a situation of success, which due to the real «living» of students in various arts provides a qualitatively new level of organization of interaction between teachers and students.

Preparation of future educators for moral and ethical education of preschoolers is a continuous managed process that should orient applicants to cultural values, formation of ideas about the culture of the Ukrainian people and ensure the implementation of the competence approach in future professional pedagogical activities.
PRINCIPLES, METHODS, FORMS AND TYPES OF THE ORGANIZATION OF STUDENT SELF-GOVERNMENT IN THE UNIVERSITIES OF UKRAINE IN THE 19TH – EARLY 20TH CENTURIES
Authors: MOKLIAK V.
Published: October 2022

In the process of scientific research, it was found that the following bodies of student self-government were active during the studied period: Stage I (1804–1863) – student economic organizations, scientific societies, society of lovers of domestic literature, Bible society, literary circles, public intellectual circles, Slavophile circles, student theater, Kharkiv-Kyiv secret society, social court (court of honor), student libraries and reading rooms, private libraries, Lithuanian Corporation of Kyiv University, mutual aid funds, communes; Stage ІІ (1863–1884) – mutual aid societies, compatriots, student canteens, mutual aid funds, educational circles and public educational organizations, self-education circles, libraries, self-education circles; Stage ІІІ (1884–1900) – fellowships, library associations, cash registers and mutual aid societies, scientific circles, student canteens, Union Councils, Kharkiv Union Council of United Organizations and Fellowships, Ukrainian Student Community, Union Council of United Fellowships and Organizations, and the Executive Committee of the Imperial Novorossiysk University; Stage IV (1900–1917) – elders, student military wives, canteens, professional unions, cash registers and mutual aid societies, student shops, scholarship commissions, social courts, fellows, scientific circles, student senate, Council of Student Deputies of Kharkiv Imperial University.

The principles of student self-government (democracy, legality, openness, equality, accountability, responsibility, etc.) are highlighted; methods (communication, introspection, conversation, discussion, the example of an older person, self-control, etc.); forms (associations, communes, communities, mutual aid funds, circles, library associations, partnership courts, etc.); types (general meetings, congresses, gatherings, gatherings, classes, meetings, etc.).

Students (the “eternal students” certainly played a special role in it) by combining the traditions and customs of their educational institution, created rules of behavior in the student environment, which were strictly followed, appealed to these rules at student courts of honor. These rules were called “codes of honor”. They were never rigidly fixed and were mostly fixed conventionally. They included a list of the so-called “natural rights of a student”. They are: the right to be called a student and wear a student uniform (the main feature of corporate style); the right to inviolability and impunity; recognition of guilt and punishment for it belonged to the competence of the court of honor only (“presumption of innocence”); the right to board; the right to corporate assistance; the right to create student organizations.
PECULIARITIES OF TRAINING OF RUNNING AND BASICS OF TRACK AND FIELD ATHLETICS TECHNIQUE
Authors: MOROZ F. , GAVRYSHKO S.
Published: October 2022

A healthy way of life is the effective and reliable means of maintenance and strengthening of health in the training of running. The lesson of physical culture plays the important role in the system of various organizational forms that is the basic form of physical education of a learner in the peculiarity of training of bases of technique on track-and-field. The mentioned tasks in the training of running are realized by purposeful maintenance, correct organization and selection of dosage of physical exercises taking into account the state of health, physical development, age-old and sexual features of students.

In physical education classes, while learning to run, students acquire a fairly complete knowledge of motor activities, acquire the necessary motor skills and abilities. Athletics can improve your ability to control your movements, make them fast and economical. And the main tasks of athletics classes are to further improve health, promote proper physical development and comprehensive training of students. When performing athletic exercises, almost all muscle groups of the body are strengthened, dexterity and endurance are developed. Volitional qualities are also brought up in the process of running, the ability to calculate one's strengths and overcome obstacles is developed.
PROFESSIONAL CULTURE AND COMPETENCE OF MAYBE OFFICERS: RELATIONSHIP AND PROVIDING WAREHOUSEHOLDERS
Authors: ONIPKO V.
Published: October 2022

In the article, in line with the problem of rozbudovi i zmіtsnennya Zbroynyh Forces and right-wing military formations of Ukraine, the need for the development of professional culture of future officers in the military ZVO, which should be methodical, advanced and technologically advanced, has been updated.

Metoyu stattі in ruslі rozglyadu Especially realіzatsії provіdnih metodologіchnih zdobutkіv suchasnoї teorії that practice profesіynoї pіdgotovki th dosyagnen gumanіtarnih that psycho-pedagogіchnih Sciences at vіyskovіy sferі viznacheno aktualіzatsіyu power pіdvischennya rіvnya profesіynoї culture maybutnіh ofіtserіv zasobami formuvannya such її komponentnіv, yak methodically doslіdnitska th, tehnologіchna kompetentnіst .

The concept of "professional competence" has been tlumed as a suborder of the concept of "professional culture" and such that it is based on the professional instrumental competencies of a future officer, how to avenge: a methodical skladnik - understanding and ker_vnitstvo fahovim dokіllya, organization and optimization of the hour, as well as reducing the vibudovuvat strategy of learning, solving and solving problems; doslidnitsky skladnik - volodinnya directing to a thorough improvement of knowledge, intelligence, skills, readiness and motivation to wine work and improvement of її results; technologic warehousing – building of victorious equipment, zdіbnosti and computer skills of information management; communicative skladnik – linguistic vminnya and competence.
SELF-ASSESSMENT OF EDUCATIONAL ACTIVITY OF GENERAL SECONDARY EDUCATION INSTITUTION
Authors: REZNIK S.
Published: October 2022

In order to ensure the provision of quality educational services in general secondary education, it is necessary to systematically identify positive and negative factors that affect the functioning of the institution, to conduct a comprehensive study - self-assessment of educational activities. It is the systematic monitoring of results and their adjustment that contribute to the effective strategic development of the educational institution and the construction of an internal system  of quality of education.

The article analyzes the algorithm of self-assessment of educational activities, which secondary schools conducted once every 10 years before the certification of the educational institution, without involving all participants of educational process, subjectively assessing management processes and demonstrating only a formal attitude to its conduct.

At the present stage, general secondary education institutions are obliged to create and ensure the functioning of the internal system of quality assurance of education, which provides for annual self-assessment of educational activities, but there is no technology and tools for internal monitoring.

Given that each secondary school must develop its own algorithm for evaluating all educational processes, there is an indicative list of internal monitoring measures and tools, (the factor-criterion model) with the help of which you can objectively assess the educational activities of the educational institution.

The results of self-assessment are an effective tool to check the correctness of the set course of development of a general secondary education institution and to make adjustments to the development strategy of the institution in order to improve the quality of educational services.
APPLICATION OF GEOGRAPHICAL INFORMATION SYSTEM IN THE TRAINING OF FUTURE GEOGRAPHY TEACHERS
Authors: FEDІI O. , VISHNIKIN L. , SHUKANOVA A.
Published: October 2022

The most important condition for training specialists in modern higher education institutions is the possession of information systems and technologies. The article highlights the relevance of training future teachers of geography via using modern geographic information systems. Informatization of society ensures the future development of science, education, production, forms a reality.

For future teachers of geography it is important to be able to apply modern methods of information processing, use databases to develop projects based on modern geographical information systems.

The article analyzed the importance of using software in the educational process on the example of open GIS SAGA and QGIS, the use of resources of EO Browser, Giovanni, Google (GoogleEarth). The specifics of the work of students of geographical specialties is the ability to operate with data that have geo-referenced objects, their mutual location in the territory, consistency between many factors of territorial organization. The result of such activities is a developed geographical map or system project. They demonstrate the patterns of distribution of objects or processes in the territory.

The article identifies competency-oriented approaches in teaching future geography teachers in an information-modernized educational space. Working with open GIS SAGA during the implementation of practical tasks allows you to form general and professional competencies, soft skills – the ability to act collectively and teamwork skills.

The importance of geographic information systems makes it necessary to increase the number of hours in student curricula. The curriculum for the training of specialists is constantly being improved by making suggestions by students, teachers, and stakeholders.
PROJECT METHOD IN THE COURSE “FUNDAMENTALS OF ANTHROPOLOGY, BIOLOGY AND HUMAN GENETICS”: FORMATION OF PROFESSIONAL COMPETENCES IN WOULD-BE TEACHERS OF BIOLOGY AND HEALTH STUDIES
Authors: YUSYPIVA T.
Published: October 2022

The paper studies the methodological aspects of applying the project method by students majoring in 014. Secondary education in the course "Fundamentals of Anthropology, Biology and Human Genetics" and the formation of professional competencies of would-be teachers of Biology and Human Health in the field of Genetics. It is shown that the use of project technology for the study of the course of human genetics is only possible with high professionalism of the teacher. The teacher must thoroughly develop methods of working with the project, formulate clear instructions for its implementation, evaluation criteria, provide methodological support, and act as a facilitator during the project. It is demonstrated that project work on human genetics is a holistic structural didactic unit that has its purpose, content, and a problem task, solution to which requires performing a series of structured sub-tasks.

It is ascertained that the student effective work on the project includes stages of searching for scientific literature on methodological aspects of the role of clinical and genealogical method in human genetic research and genealogical analysis; collecting data on the family on the basis of research (starting with proband); formation of a legend on this basis and formulation of a task to determine the probability of occurrence in the family of a proband of children with the studied feature; compilation of a pedigree chart; analysis of the constructed pedigree; determining the type of inheritance of the studied trait; calculating the probability of birth in the family of proband offspring with the studied trait.

It was found that on competing the project 57.1% of students achieved a high level of formation of the general and special competencies in the future specialty, 17.9% - intermediate level, 21.4% - sufficient, and 3.6% - low level. The research proves the effectiveness of project method in the study of the course "Fundamentals of Anthropology, Biology and Human Genetics" for the formation of general and special competencies in would-be teachers of biology and human health in the field of genetics. Not only the level of motivation of students to obtain genetic knowledge increased, but also their interest in the project, as such work helps to expand knowledge about close and distant relatives, family relationships, increase respect for their own family, development of logical thinking, and creative thinking.
Evaluación formativa en el proceso enseñanza y aprendizaje durante la pandemia COVID-19
Authors: Casa-Coila Manuela Daishy , Yana Salluca Marisol , Mamani Jilaja Dometila , Alanoca Gutierrez Rebeca , Perez Argollo Katia
Published: October 2022

La evaluación formativa en el proceso de enseñanza y aprendizaje, fue un reto durante la pandemia de la COVID-19. El objetivo del estudio es analizar la evaluación formativa en educación durante la pandemia. La metodología fue la búsqueda y selección de 22 artículos científicos indexadas en bases de datos de Scopus, Web Of Science, Scielo, los estudios recopilados de evaluación en el marco del enfoque por competencias durante la educación en tiempos de pandemia, partiendo de las evidencias de aprendizaje de acuerdo con los criterios de evaluación establecidos en el desarrollo del proceso de aprendizaje. La conclusión fue que la retroalimentación oportuna es un proceso efectivo para valorar los desempeños de los estudiantes en el logro del aprendizaje, centrados en la calidad del producto, ello es logrado mediante la autoevaluación, autonomía, motivación y reflexión para mejorar el aprendizaje en los estudiantes.
Gestión educativa estratégica de calidad en una I.E. Pública de Ancash
Authors: Malpaso Morales Rosana Claudia , Lapa Huaman Gloria
Published: October 2022

Este estudio plantea con finalidad determinar el proceso predominante de la Gestión Educativa Estratégica de calidad, que aporten en la transformación de la gestión que desarrollan los directivos a partir del liderazgo pedagógico; ya que es el segundo factor de influencia en los logros de aprendizaje. El propósito de estudio es generar condiciones para que se produzca el cambio, y al líder directivo, la preparación para afrontar la complejidad. La metodología corresponde a un nivel correlacional, con enfoque cuantitativo, el tipo de estudio descriptivo explicativo de diseño no experimental; por tanto, se ha revisado información científica que datan desde los años 2002 al 2017, como referencias bibliográficas, palabras clave, dichas bases de datos consultadas corresponden a Scielo, Scopus. Se concluye que, para lograr una Gestión Educativa Estratégica de calidad se debe tomar en cuenta los principios de la Gestión educativa.
Chemical Characteristics and Essential Nutrients of Agroindustrial Effluents in Malaysia
Authors: HABIB M.A.B.
Published: October 2022

Three major agroindustrial effluents, namely, palm oil mill effluent (POME), latex concentrate rubber effluent (LCRE) and standard Malaysian rubber effluent (SMRE), were analyzed for chemical characteristics and biochemical properties and their essential nutrients evaluated. All the three raw effluents were highly acidic and did not contain dissolved oxygen. The raw POME contained significantly (p<0.05) higher chemical oxygen demand (COD) than raw LCRE followed by SMRE, indicating a high load of organic nutrients in these ef­fluents. Crude protein in raw SMRE and LCRE was significantly higher than that in raw POME. But crude lipids, carbohydrate and ash content of raw POME were found to differ significantly (p<0.05) from those of raw LCRE and SMRE. All the 11 essential amino acids were available in raw LCRE, SMRE and POME. The POME contained higher amounts of unsaturated fatty acids such as oleic acid (18: ln-9), linoleic acid (18: 2n-6), linolenic acid (18: 3n-3) and arachidonic acid (20: 2n-6) than the other effluents. However, very little amounts of eicosapentaenoic acid (20:5n-3) were available in POME only. All together, 27 essential minerals were detected by scanning electron microscope and 22 essential minerals were quantified by Inductively Coupled Plasma Mass Spectrophotometer, among which, Fe, Zn, P, Mg, Mn, Ca, K, Cr, Co, Cu, S, Se, Al, Sn, B, Mo, V, Li and Pb were found to be significantly (p<0.01) higher in raw POME than in the other effluents.