bluuebunny/crossref_metadata_2025 huggingface dataset:
Erdheim-Chester disease with Rosai-Dorfman-like lesions: treatment with methotrexate, anakinra and upadacitinib
Authors: Portegys Jan , Heidemeier Anke , Rosenwald Andreas , Gernert Michael , Fröhlich Matthias , Hueper Sebastian , Strunz Patrick Pascal , Rasche Leo , Schmalzing Marc
Published: January 2023

Erdheim-Chester disease (ECD) is a non-Langerhans cell histiocytosis characterised by clonal expansion of histiocytes in various organs. These induce an inflammatory environment, which leads to damage of the affected areas. Recently, a new disease entity was proposed encompassing key features of ECD but also of Rosai-Dorfman-Destombes disease, another histiocytosis. Mitogen-activated protein kinase kinase 1 (MAP2K1)mutations seem to present a specific genetic lesion for this subtype.

Here, we describe a case of this new disease entity with clinical, radiological and genetic findings compatible with ECD but histological findings compatible with Rosai-Dorfman-Destombes disease. In particular, there were intraabdominal and retroperitoneal lesions, which tested positive for a (c.167A>C; p.Q56P) mutation of the MAP2K1 gene. On histological examination, S100-positive, giant histiocytes with focal emperipolesis of haematological cells in addition to infiltration by lymphocytes and granulocytes were seen.

As described for this rare variant of ECD, there was also bilateral testicular infiltration. We also describe a manifestation of oligoarthritis in this patient with ECD.

The patient was treated with methotrexate and prednisolone. While radiological response to this regime was excellent, arthritis persisted. We added anakinra, which induced a response of the arthritis for more than a year. Due to treatment failure therapy was switched to upadacitinib, which induced a remission of the arthritis as well.

This case adds a rare phenotype to an already rare presentation of ECD. The patient responded to immunosuppressive therapy.
$$P_{cc}^N$$ states in a unitarized coupled-channel approach
Authors: Shen Chao-Wei , Lin Yong-hui , Meißner Ulf-G.
Published: January 2023

Starting from an effective Lagrangian with heavy quark spin symmetry embedded, the coupled-channel dynamics of the doubly charmed systems $$D^{(*)} \Sigma _c^{(*)}$$

D

(

∗
)

Σ
c

(

∗
)

is investigated. The potential underlying our investigation includes t-channel pseudoscalar and vector meson exchanges. A series of S-wave bound states with isospin $$I=1/2$$

I
=
1
/
2

is found by applying the first iterated solution of the N/D method: one state with binding energy 23  MeV in the $$5/2^-$$

5
/

2
-

$$D^*\Sigma _c^*$$

D
∗

Σ
c
∗

channel, three states with binding energy 26, 30 and 7 MeV (relative to the thresholds from low to high, respectively) in the $$3/2^-$$

3
/

2
-

$$D\Sigma _c^*$$

D

Σ
c
∗

-$$D^*\Sigma _c$$

D
∗

Σ
c

-$$D^*\Sigma _c^*$$

D
∗

Σ
c
∗

system and three states with binding energy 32, 8 and 16 MeV in the $$1/2^-$$

1
/

2
-

$$D\Sigma _c$$

D

Σ
c

-$$D^*\Sigma _c$$

D
∗

Σ
c

-$$D^*\Sigma _c^*$$

D
∗

Σ
c
∗

system. Those $$P_{cc}^N$$

P

cc

N

states serve as the open-charm partners of the hidden charm pentaquarks $$P_{\psi }^N$$

P

ψ

N

observed by the LHCb Collaboration.
Synergistic Amplification Signal Based on CoNPs and Melamine for Simultaneous Quantification of Epinephrine and Serotonin
Authors: Shan Chen-Wei , Feng Xiao-Zhen , Han Guo-Cheng , Chen Zhencheng , Kraatz Heinz-Bernhard
Published: January 2023

Here we report an electrochemical sensor for the detection of epinephrine (EP) and serotonin (5-HT), two important neurotransmitters in the mammalian central nervous system, which are also present in serum. Their concentration will affect the psychological and physiological activities of the human body, especially in regulating emotions. Therefore, it is very important to detect EP and 5-HT simultaneously. Herein, cobalt nanoparticles (CoNPs) and melamine (MEL) were deposited on a glassy carbon electrode (GCE) by cyclic voltammetry (CV), resulting in an electrochemical sensor (MEL/CoNPs/GCE) that allowed the detection of both EP (0.23 V) and 5-HT (0.38 V vs. Ag/AgCl). Square wave voltammetry (SWV) measurements allowed us to establish a linear range of EP and 5-HT in the range of 5.00 to 500.00 μmol·l−1, with a limit of detection of 1.60 μmol·l−1 for EP, and of 2.52 μmol·l−1 for 5-HT. The detection sensitivity were 1.38 and 1.62 μA·μM−1·cm−2 for EP and 5-HT. Finally, the sensor also was used to detect serum with a recovery of 92.8% to 98.2% for EP, 98.7% to 99.0% for 5-HT, with RSD of 3.3%, indicated that it can be used for the rapid and simultaneous detection of EP and 5-HT.
Epinephrine iontophoresis attenuates changes in skin blood flow and abolishes cutaneous contamination of near-infrared diffuse correlation spectroscopy estimations of muscle perfusion
Authors: Bartlett Miles F. , Palmero-Canton Alberto , Oneglia Andrew P. , Mireles Julissa , Brothers R. Matthew , Trowbridge Cynthia A. , Wilkes Dustin , Nelson Michael D.
Published: January 2023

Near-infrared diffuse correlation spectroscopy (NIR-DCS) is an optical imaging technique for measuring relative changes in skeletal muscle microvascular perfusion (i.e., fold change above baseline) during reactive hyperemia testing and exercise and is reported as a blood flow index (BFI). Although it is generally accepted that changes in BFI are primarily driven by changes in muscle perfusion, it is well known that large, hyperthermia-induced changes in cutaneous blood flow can uncouple this relationship. What remains unknown, is how much of an impact that changes in cutaneous perfusion have on NIR-DCS BFI and estimates of skeletal muscle perfusion under thermoneutral conditions, where changes in cutaneous blood flow are assumed to be relatively low. We therefore used epinephrine iontophoresis to pharmacologically block changes in cutaneous perfusion throughout a battery of experimental procedures. The data show that 1) epinephrine iontophoresis attenuates changes in cutaneous perfusion for up to 4-h posttreatment, even in the face of significant neural and local stimuli, 2) under thermoneutral conditions, cutaneous perfusion does not significantly impact NIR-DCS BFI during reactive hyperemia testing or moderate-intensity exercise, and 3) during passive whole body heat stress, when cutaneous vasodilation is pronounced, epinephrine iontophoresis preserves NIR-DCS measures of skeletal muscle BFI during moderate-intensity exercise. Collectively, these data suggest that cutaneous perfusion is unlikely to have a major impact on NIR-DCS estimates of skeletal muscle BFI under thermoneutral conditions, but that epinephrine iontophoresis can be used to abolish cutaneous contamination of the NIR-DCS BFI signal during studies where skin blood flow may be elevated but skeletal muscle perfusion is of specific interest.
Machine Learning Integrated Multivariate Water Quality Control Framework for Prawn Harvesting from Fresh Water Ponds
Authors: Kaur Gaganpreet , Braveen M. , Krishnapriya Singamaneni , Wawale Surindar Gopalrao , Castillo-Picon Jorge , Malhotra Dheeraj , Osei-Owusu Jonathan
Published: January 2023

Water contamination, temperature imbalance, feed, space, and cost are key issues that traditional fish farming encounters. The aquaculture business still confronts obstacles such as the development of improved monitoring systems, the early detection of outbreaks, enormous mortality, and promoting sustainability, all of which are open problems that need to be solved. The goal of this study is to provide a machine learning (ML)-based aquaculture solution that boosts prawn growth and production in ponds. The study described a proposed framework that collects data using sensors, analyses it using a machine learning framework, and provides results like a preferred list of water quality (QOW) variables that affect prawn development and yield, as well as pond categorization into low, medium, and high prawn-producing ponds. In this study, we use eight distinct machine-learning classifiers to discover the driving elements that influence the development and yield of aquatic food products in ponds in terms of QOW variables, as well as three feature selection approaches to identify the aspects that have the largest impact on the pond's total harvest performance. To validate and obtain satisfying results, the suggested system was installed and tested. The average F score and accuracy when yield is employed as a harvest parameter are determined to be 0.85 and 0.78, respectively. The average merit ratings of temperature, dissolved oxygen, and salinity are significantly higher than those of the other QOW components. The temperature variations are greatest during the second, fourth, and seventh weeks. Temperature, salinity, and dissolved oxygen are the three QOW variables that have the largest influence on overall pond harvest performance, according to the data. Additionally, it has been discovered that a key QOW factor in separating high-yielding ponds from low-yielding ponds is the temperature change following stocking.
The Lower Limb Movements of the Fetus in Uterus: A Narrative Review
Authors: Zhao Xiaoxue , Awrejcewicz Jan , Li Jianpeng , He Yuhuan , Gu Yaodong
Published: January 2023

The fetus movements play an important role in fetal well-being. With the continuous advancement of real-time scanning machines, it is feasible to observe the fetus movement in detail. The characteristics of fetal lower limb movements in prenatal examination have not been systematically investigated. This review proposes the patterns of fetal lower limb movements, the maternal influence on fetal lower limb movements, and the application of fetal lower limb movements for the diagnosis of prenatal diseases. A systematic search of literature on the lower limb movements of the fetus in uterus was performed in the databases, namely, Web of Science and Scopus. Thirty-four publications were selected. This review demonstrates that isolated fetal lower limb movements are rare and always accompanied with the movements of other body segments. Detection of the presence of fetal leg movements seems to be of no diagnostic value for fetuses with prenatal diseases. The isolated lower limb movement was statistically significant different between fetuses of low- and high-risk pregnant women. The coordinated movements of the fetal lower limbs and other parts should be considered when analyzing fetal movements in the future study.
An Adaptive Injection Model for Pansharpening
Authors: Song Qun , Ding Chen , Ren Junhua , Liu Lili , Lu Hangyuan
Published: January 2023

Pansharpening technology is used to acquire a multispectral image with high spatial resolution from a panchromatic (PAN) image and a multispectral (MS) image. The detail injection model is popular for its flexibility. However, the accuracy of the injection gain and the extracted details may greatly influence the quality of the pansharpened image. This paper proposes an adaptive injection model to solve these problems. For detail extraction, we present a Gaussian filter estimation algorithm by exploring the intrinsic character of the MS sensor and convolving the PAN image with the filter to adaptively optimize the details to be consistent with the character of the MS image. For the adaptive injection coefficient, we iteratively adjust the coefficient by balancing the spectral and spatial fidelity. By multiplying the optimized details and injection gain, the final HRMS is obtained with the injection model. The performance of the proposed model is analyzed and a large number of tests are carried out on various satellite datasets. Compared to some advanced pansharpening methods, the results prove that our method can achieve the best fusion quality both subjectively and objectively.
Application of Artificial Intelligence in Anatomical Structure Recognition of Standard Section of Fetal Heart
Authors: Wu Huiling , Wu Bingzheng , Lai Fangping , Liu Peizhong , Lyu Guorong , He Shaozheng , Dai Jiangfeng
Published: January 2023

Congenital heart defect (CHD) refers to the overall structural abnormality of the heart or large blood vessels in the chest cavity. It is the most common type of fetal congenital defects. Prenatal diagnosis of congenital heart disease can improve the prognosis of the fetus to a certain extent. At present, prenatal diagnosis of CHD mainly uses 2D ultrasound to directly evaluate the development and function of fetal heart and main structures in the second trimester of pregnancy. Artificial recognition of fetal heart 2D ultrasound is a highly complex and tedious task, which requires a long period of prenatal training and practical experience. Compared with manual scanning, computer automatic identification and classification can significantly save time, ensure efficiency, and improve the accuracy of diagnosis. In this paper, an effective artificial intelligence recognition model is established by combining ultrasound images with artificial intelligence technology to assist ultrasound doctors in prenatal ultrasound fetal heart standard section recognition. The method data in this paper were obtained from the Second Affiliated Hospital of Fujian Medical University. The fetal apical four‐chamber heart section, three vessel catheter section, three vessel trachea section, right ventricular outflow tract section, and left ventricular outflow tract section were collected at 20‐24 weeks of gestation. 2687 image data were used for model establishment, and 673 image data were used for model validation. The experiment shows that the map value of this method in identifying different anatomical structures reaches 94.30%, the average accuracy rate reaches 94.60%, the average recall rate reaches 91.0%, and the average F1 coefficient reaches 93.40%. The experimental results show that this method can effectively identify the anatomical structures of different fetal heart sections and judge the standard sections according to these anatomical structures, which can provide an auxiliary diagnostic basis for ultrasound doctors to scan and lay a solid foundation for the diagnosis of congenital heart disease.
Diversity and Antimicrobial Activities of Actinobacteria Isolated from Mining Soils in Midelt Region, Morocco
Authors: Ait Assou Soumia , Anissi Jaouad , Sendide Khalid , El Hassouni Mohammed
Published: January 2023

Multidrug-resistant bacteria have emerged as a serious global health threat that requires, more than ever before, an urgent need for novel and more effective drugs. In this regard, the present study sheds light on the diversity and antimicrobial potential of Actinobacteria isolates in mining ecosystems. We have indeed investigated the production of bioactive molecules by the Actinobacteria isolated from abandoned mining areas in Midelt, Morocco, where average contents of lead (Pb) and cadmium (Cd) are higher than normal world levels. One hundred and forty-five Actinobacteria isolates were isolated and characterized based on morphological, chemotaxonomical, biochemical, and molecular data. Most of the 145 isolates were identified as Streptomyces. Isolates affiliated to the genera Amycolatopsis, Lentzea, Actinopolymorpha, and Pseudonocardia were also found. Antimicrobial producing potentials of Actinobacteria isolates were assessed against eight test microorganisms Gram+ and Gram− bacteria and yeast. Out of 145 isolates, 51 showed antimicrobial activities against at least one test microorganism. 31 isolates inhibited only bacteria, 7 showed activity against bacteria and Candida albicans, and 13 displayed activity against C. albicans solely. Our findings suggest that Actinobacteria isolated from natural heavy metal ecosystems may be a valuable source of novel secondary metabolites and therefore of new biotechnologically promising antimicrobial compounds.
Mechanism and Control of Water–Rock Coupling-Induced Disaster when Mining below the Unconsolidated Confined Aquifer
Authors: Li Zhihua , Yang Ke , Hua Xinzhu , Liu Cheng , Zhou Peng , Ge Shengwen
Published: January 2023

Theoretical analysis and numerical simulation were conducted to study the disaster-causing mechanism of structural instability of the overlying strata induced by water–rock coupling and effectively prevent and control the powered support jammed accident during mining below the unconsolidated confined aquifer. The influencing factors on the stability of the overlying strata structure were analyzed, and the numerical simulation method of unconsolidated confined aquifer was designed. The disaster-causing mechanism and the evolution process of the stress–displacement–crack field of the overlying strata induced by water–rock coupling were discovered. Meanwhile, the prevention measures for the structural instability of the overlying strata were proposed and verified in some engineering practice. Results show that the stability of the overlying strata structure reduces with the increase in hydraulic pressure, the breaking interval of the main roof, and the decrease in the overlying strata strength and waterproof coal pillar height. The overlying strata structure keeps a stable equilibrium state before the fracture planes through a whole waterproof coal–rock pillar. When the hydraulic pressure is small or the bedrock surface is a thick topsoil layer, the sliding block is in a state of limit equilibrium for the decrease of pressure on the sliding block while the fracture planes through a whole waterproof coal–rock pillar because of the action of unloading during an overlying strata movement. When the hydraulic pressure is high, the pressure on the sliding block remains constant at about hydraulic pressure, and the intact shear fall of the sliding block occurs as a result of the hydraulic pressure of the confined aquifer and the weight of the sliding block, which may result in a powered support jammed accident. However, this type of accident can be prevented by drainage for decreasing hydraulic pressure, presplitting blasting of the hard main roof, overlying strata grouting reinforcement, and increasing the height of the waterproof coal–rock pillar.
Investigation of Magnesium and Chromium Fillers FSW Dissimilar Joint of AA6063 and AA 5154
Authors: Krishnamoorthi Sangeetha , Prabhahar M. , Prakash S. , Prabhu L. , Bhaskar K. , Suku Akhil V. , Shijindas K. P. , Sooraj S. L. , Haiter Lenin A.
Published: January 2023

Friction stir welding (FSW) is a solid-state metal joining process. There is no melting and recasting of metal while welding is used. Some of the defects commonly encountered in FSW are tunnel defect, bond, cracks, pin holes, and pipping defects. The defects occur because of improper metal mixing and less heat input in the weld nugget zone. In the fusion welding process, a filler rod is employed to form a quality weld with superior mechanical properties. In this work magnesium and chromium powders are used as filler materials. The purpose of this study is to ascertain whether filler materials and manufacturing processes have an impact on the weld nugget zone spot weld joint formation as well as the mechanical and abrasive properties of welded joints. This study's FSW filler materials mixing ratio and process parameters were improved by using the Central Composite Design (CCD) idea, which is discussed in more detail below Response Surface Methodology (RSM). The best empirical relationship between the parameters was provided by the CCD. The mathematical relationships were established to forecast the maximum tensile strength, maximum weld nugget hardness, and minimum corrosion rate by incorporating filler materials with process parameters. The optimal processing factors combination is predicted by conducting the validation test. The optimum parameters were the tool rotatory speed 600–1000 revolution per minute, welding speed 60 to 180 mm/min, plunge depth of 0.05 to 0.25 mm, center distance between the sample is 0–4 mm, as well as powder mixing ratio of 90 : 10, 92.5 : 7.5, 95 : 5, 97.5 : 2.5, and 100 : 0, the tensile test, microhardness, and corrosion rate analysis were conducted on the weld specimen. The welded test specimen provides better joint strength, weld nugget hardness, and enhanced corrosion resistance properties. The microstructure analysis shows the fine grain structure and homogeneous distribution of filler material with the base metal in the welded area.
Progressive Failure Analysis of Soil Slope with Strain Softening Behavior Based on Peridynamics
Authors: Wang Chen , Zhao Jianhui , Zheng Weifeng
Published: January 2023

In this study, the nonlocal, nonordinary state-based peridynamics (NOSBPD) is introduced as a novel regularization technique to study the strain localization and progressive failure of soil slopes due to strain softening behavior. The NOSBPD formulations are introduced first, and then the strain-softening Mohr–Coulomb model is incorporated into the nonlocal framework. The implicit formulations of the nonlinear NOSBPD model under the plane strain condition combined with the energy dissipation-based arc-length method to avoid the limitations of the force and displacement control in the nonlinear analysis are given. Numerical examples, including the plane strain biaxial experiments and slope models, validate the effectiveness of the proposed method in terms of alleviating mesh sensitivity. The results show that this nonlocal method can remove the mesh dependence, and the localized shear band is related to the nonlocal parameter δ. The proposed method involves being able to capture strength mobilization in different parts of the sliding surface during the progressive failure process of the soil slope. It can avoid the dilemma that the peak strength is too dangerous and the residual strength is too conservative due to the rigid body assumption in the limit equilibrium method.
Physical Activity among Rural Residents in Eastern, Central, and Western Provinces of China: A Cross‐Sectional Survey
Authors: Liang Cheng-Yao , Zheng Zhi-Yuan , Wu Yu-Gao , Li Zhuo-Yang , Wang Ping , Wang Yi-Yang , Lin Bai-Xue , Fang Jing
Published: January 2023

Physical activity (PA) in which physical exercise (PE) is an important component is probably the most important intervention for preventing noncommunicable diseases (NCDs). However, few studies on PA and PE of rural residents in China were reported. This study conducted the first population‐based cross‐sectional survey in three provinces of China in 2021 that examined both PA and PE as well as the associated factors of rural residents. The International Physical Activity Questionnaire Short Form (IPAQ‐S) was used, and a total of 3780 rural residents were surveyed. The result showed that 22.2% of the rural residents were physical inactivity and rural residents reporting practice of PE was 54.4%. Binary logistic regression analyses showed that being female, people aged between 15 to 34 years or 60 years old and above, employees of governmental departments/retirees, school students, the unemployed, and people with NCDs were risk factors of PA while ethnic minority groups, smoking, and alcohol consumption were risk factors of PE. Health promotion programme aiming at increasing people’s PA in rural China is urgently needed, and it should focus on the population groups of the female, people aged 60 years and above, school students, the unemployed, and people with NCDs.
Tribological Characterization of Epoxy Hybrid Composites Reinforced with Al2O3 Nanofiller
Authors: Dilip Kumar K. , Shantharaja M. , Kiran M. D. , Rajesh M. , Kumar Nithin , Lenin Haiter
Published: January 2023

The addition of fillers to polymer composites induces a positive influence on the mechanical and tribological properties of the hybrid composites. These properties can be validated for possible uses such as automobile, construction, shipping, aerospace, sports equipment, electronics, and biomedical domains. In the present research, epoxy matrix reinforced with nylon-6 fibers and glass fibers were prepared using the solution blend technique. Alumina nanoparticles are added as fillers to enhance the properties of epoxy hybrid composites. The large surface area of interaction of nanofillers exhibits better adhesion between matrix and fibers of composites, and it significantly affects the various properties of composites. The tribological characteristics of fabricated epoxy hybrid composites were evaluated under various parameters and conditions. The results revealed that the addition of nanofiller significantly reduces the wear loss of epoxy hybrid nanocomposites. The wear resistance of epoxy hybrid composites increased with increase in addition of nanofiller up to 1.0%, and it slightly decreased with the further addition of filler. The Taguchi analysis was carried out for the least coefficient of friction and specific wear rate. The analysis found that the specific wear rate and coefficient of friction mainly depend on load, followed by speed and nanofiller. The fractured and worn surface of Al2O3-filled epoxy hybrid composites was analysed using SEM.
On Generalized Caristi Type Satisfying Admissibility Mappings
Authors: Almazah Mohammed M. A. , Hardan Basel , Hamoud Ahmed A. , Ali Faisal A. M.
Published: January 2023

In this article, the existence and uniqueness of a fixed point were investigated using the concept of

σ
,
γ

-contractive in the context of Hausdorff metric space. A well-known Caristi type is primarily generalized by the new results. The result is improved by building up an example.
Anastomotic Leakages after Surgery for Gastroesophageal Cancer: A Systematic Review and Meta-Analysis on Endoscopic versus Surgical Management
Authors: Azevedo Isabel , Ortigão Raquel , Pimentel-Nunes Pedro , Bastos Pedro , Silva Rui , Dinis-Ribeiro Mário , Libânio Diogo
Published: January 2023

Introduction: With the increase of esophageal and gastric cancer, surgery will be more often performed. Anastomotic leakage (AL) is one of the most feared postoperative complications of gastroesophageal surgery. It can be managed by conservative, endoscopic (such as endoscopic vacuum therapy and stenting), or surgical methods, but optimal treatment remains controversial. The aim of our meta-analysis was to compare (a) endoscopic and surgical interventions and (b) different endoscopic treatments for AL following gastroesophageal cancer surgery. Methods: Systematic review and meta-analysis, with search in three online databases for studies evaluating surgical and endoscopic treatments for AL following gastroesophageal cancer surgery. Results: A total of 32 studies comprising 1,080 patients were included. Compared with surgical intervention, endoscopic treatment presented similar clinical success, hospital length of stay, and intensive care unit length of stay, but lower in-hospital mortality (6.4% [95% CI: 3.8–9.6%] vs. 35.8% [95% CI: 23.9–48.5%]. Endoscopic vacuum therapy was associated with a lower rate of complications (OR 0.348 [95% CI: 0.127–0.954]), shorter ICU length of stay (mean difference −14.77 days [95% CI: −26.57 to −2.98]), and time until AL resolution (17.6 days [95% CI: 14.1–21.2] vs. 39.4 days [95% CI: 27.0–51.8]) when compared with stenting, but there were no significant differences in terms of clinical success, mortality, reinterventions, or hospital length of stay. Conclusions: Endoscopic treatment, in particular endoscopic vacuum therapy, seems safer and more effective when compared with surgery. However, more robust comparative studies are needed, especially for clarifying which is the best treatment in specific situations (according to patient and leak characteristics).
A Dutch Pre-DSM Attempt at Psychiatric Classification
Authors: Sno Herman N.
Published: January 2023

Considering the growing sense of ambivalence about the merits of the DSM, the time seems right for the re-evaluation of nosological attempts and efforts in the pre-DSM era. One example of these attempts is the CHAM system developed by the Dutch psychiatrist R.M. Silbermann (1932–1976). This system is intended as a simple classification with 20 “psychiatric states,” which are classified based on the presence of one of 12 hierarchically arranged core symptoms or key characteristics, while all “hierarchically higher” symptoms are excluded without inference about the “hierarchically lower” symptoms. Its scientific evidence is, as yet, insufficiently substantiated. However, disqualifying the CHAM system as an outdated Dutch folklore is like throwing out the baby with the bathwater. The CHAM system emerges as clinically straightforward, didactically fruitful, and consistent with more modern initiatives in descriptive psychopathology. Studying pre-DSM attempts such as Silbermann’s CHAM system can stimulate psychopathological thinking and serve as a source of inspiration for future phenomenological research in psychiatry.
Short Brown Parallel Lines on the Proximal Nail Fold. Clinical-Dermoscopic-Histologic Correlation of a Melanocytic Nevus of the Eponychium
Authors: Algarra-Sahuquillo Judit , Ramos-Rodríguez Daniel , Santos-e-Silva Caldeira-Marques María-Luísa , Mercader-Salvans Júlia , Rodríguez-Rodríguez Rosa-Nieves , Hernández-León Carmen-Nieves , Guimerá Martin-Neda Francisco
Published: January 2023

Introduction: Although Hutchinson’s sign can appear associated with benign conditions, dermoscopic findings of non-melanoma eponychium pigmentation have not yet been described in the literature. We report for the first time to our knowledge the dermoscopic findings of an acral nevus located in the proximal nail fold as well as its clinical-dermoscopic-histologic correlation. Case Report: A twenty-year-old patient presented with a homogeneous longitudinal melanonychia on the left-hand thumb, with benign dermoscopic pattern, and an irregular, 6-mm, dark-brown hyperpigmented macule on the adjacent eponychium (Hutchinson’s sign). The eponychium lesion showed on dermoscopy two irregular brown-black pigmented blotches, with superimposed parallel brown lines on a brushy distribution, with a thicker terminal end. The histopathologic examination of the proximal nail fold was performed, revealing scattered nevus cells in the epidermal basal layer and dermal-epidermal junction thecae, without any atypia or mitosis. These features were consistent with nevus of the proximal nail fold. Discussion: Previous descriptions of benign hyponychium’s pigmentations, despite the malignant appearance of the overlying melanonychia, were reported to have a similar dermoscopic pattern, known as longitudinal brushy pigmentation. This newly described dermoscopic sign on the eponychium may help distinguish Hutchinson’s sign related to subungual melanoma to non-melanoma Hutchinson’s sign.
Xpert MTB/RIF in the Diagnosis of Mediastinal Tuberculous Lymphadenitis by Endoscopic Ultrasound-Guided Needle Aspiration Techniques: A Systematic Review and Meta-Analysis
Authors: Mondoni Michele , Saderi Laura , Puci Mariangela Valentina , De Pascalis Sabrina , Re Beatrice , Centanni Stefano , Sotgiu Giovanni
Published: January 2023

Background: Lymphadenopathy is one of the most prevalent clinical manifestations of extrapulmonary tuberculosis. Endosonography is the recommended technique in the diagnostic work-up of mediastinal lymphadenopathies. Xpert MTB/RIF assay is a self-contained cartridge-based fully automated DNA testing platform which can accurately detect both tuberculosis and mycobacterial resistance to rifampicin. A few studies assessed its accuracy for mediastinal lymph node aspirates collected using endosonography. A systematic review of observational studies was performed to provide a pooled estimate of sensitivity and specificity of Xpert MTB/RIF in the diagnosis of mediastinal tuberculous lymphadenitis using endoscopic ultrasound-guided needle aspiration techniques. Methods: A search of the scientific evidence was carried out using PubMed, Embase, and Scopus. Articles describing observational studies on Xpert MTB/RIF in the diagnosis of mediastinal tuberculous lymphadenitis using endoscopic ultrasound-guided needle aspiration techniques were selected. Results: Eight studies met the inclusion criteria. The overall pooled sensitivity was 61% (95% CI = 55–68%; I2 = 66.3%; p = 0.004), overall pooled specificity was 89% (95% CI = 85–91%; I2 = 90.1%; p < 0.0001). Area under the sROC curve was 0.68. Only one study reported data on rifampin resistance detection and showed a sensitivity of 83.3% and a specificity of 16%. Conclusions: Xpert MTB/RIF shows a good accuracy in the diagnosis of mediastinal mycobacterial lymphadenitis by endosonographic needle aspiration techniques. It should be always recommended for suspected mediastinal tuberculosis.
Entdeckung von Autoantigenen bei der Haarverluststörung Alopecia areata: Implikation von posttranslationalen Modifikationen
Authors: Jadeja Shahnawaz D. , Tobin Desmond J.
Published: January 2023

Alopecia areata (AA) ist eine chronische, multifaktorielle, polygene und heterogene Erkrankung, die wachsende Haarfollikel bei anfälligen Personen betrifft und zu einem nicht vernarbenden und reversiblen Haarausfall mit höchst unvorhersehbarem Verlauf führt. Trotz sehr erheblichem Forschungsaufwand bleibt die Art des/der auslösenden Faktors/en, der/die für die Initiierung von AA in einem bestimmten Haarfollikel verantwortlich ist (sind), unklar, was weitgehend auf signifikante Wissenslücken bezüglich der genauen Abfolge der ätiopathogenen Ereignisse bei dieser Dermatose zurückzuführen ist. Jedoch sind krankheitsbedingte Veränderungen in der Immunkompetenz im unteren Bereich des wachsenden Haarfollikels zusammen mit einer aktiven Immunantwort (humoral und zellulär) auf Haarfollikel-assoziierte Antigene wichtige Schlüsselphänomene. Die genaue Identität des/der Haarfollikel-Antigens/e, das/die mit dem Ausbruch der AA-Krankheit in Verbindung steht/stehen, blieb schwer zu fassen. Während es von einigen als eher philosophische Frage angesehen werden mag, ist auch unklar, ob immunvermittelter Haarausfall bei AA die Folge von a) einer ektopischen (d.h. an einer abnormalen Stelle) Immunantwort auf native (unmodifizierte), vom gesunden Haarfollikel exprimierte Selbst-Antigene ist oder von b) einer normalen Immunantwort gegen modifizierte Selbst-Antigene (oder Neoantigene) oder von c) einer normalen Immunantwort gegen Selbst-Antigene (modifiziert/nicht modifiziert), die zuvor für das Immunsystem nicht sichtbar waren (weil sie konformationell versteckt oder sequestriert waren), aber auf eine MHC-I/II-Molekül-abhängige Weise exponiert und präsentierbar werden. Während sich einige potenzielle Haarfollikel-Zielantigene bei AA abzuzeichnen beginnen, mit einer potenziellen Rolle von Trichohyalin, ist noch unklar, ob dies den anfänglichen und immundominanten antigenen Fokus bei AA darstellt oder ob es nur eines aus einem wachsenden Repertoire von Antigenen ist, die mit den exponierten Gewebeschäden im Haarfollikel assoziiert sind und sekundär zur Krankheit beitragen. Die Bestätigung der Autoantigenidentität ist für unser Verständnis der AA-Ätiopathogenese und folglich für die Entwicklung einer fundierteren therapeutischen Strategie von großer Bedeutung. Große Fortschritte sind bei der Entdeckung von Autoantigenen im Zusammenhang mit anderen Autoimmunerkrankungen erzielt worden. Insbesondere können einige dieser Erkrankungen darüber Aufschluss geben, wie posttranslationale Modifikationen (z.B. Citrullinierung, Desamidierung usw.) von Haarfollikel-spezifischen Proteinen ihre Antigenität erhöhen und so dazu beitragen können, den Anti-Haarfollikel-Immunangriff bei AA voranzutreiben.
Deriving equivalent structure of elements for low density parity check codes construction
Authors: Ahmad Zaeni Jenjen , Muzhofi Fandy Ali , Solehudin Cecep , Anwar Khoirul , Ismail Nanang
Published: January 2023

This paper proposes a method to derive equivalent coding structures of elements to construct low density parity check (LDPC) codes. We propose stairs LDPC (SLDPC) codes to demonstrate the effectiveness of the proposed method, which is expected to be beneficial for short block-length transmissions, but providing high coding rate. The equivalent coding structures are both for transmitter and receiver to: (i) reduce the encoding and decoding computational complexity, and (ii) search possibility of finding new coding scheme and observe their performances. We evaluate the validity of the method by confirming the equality in performances of the SLDPC codes in terms of bit-error-rate (BER) followed by investigation on their performance gaps to the Shannon limit via a series of computer simulations. The results show that the SLDPC codes have the same BER performance with that of the low density generator matrix (LDGM) codes confirming the validity of the proposed equivalent matrix derivation. This result indicates that different graphs can provide the same performances, because their equivalent matrices are the same. This result is expected to open new insight for the designing simple channel coding for short block-length LDPC codes having high coding rate for future less power consumption applications.
Transformation to a smart factory using NodeMCU with Blynk platform
Authors: Abdulhakeem Hailan Maryam , Munqith Albaker Baraa , Shyaa Alwan Muwafaq
Published: January 2023

Incorporating internet of things (IoT) in industrial systems prompted the development of industrial internet of things (IIoT) systems, which in turn enable the automation of intelligent devices to gather, analyze, and transmit data from industrial systems in real-time. This paper develops a low-cost and smart industrial remote monitoring and control system based on NodeMCU microcontrollers and Blynk server platform. It is deployed to remotely monitor manufacturer's environment and industrial equipment and control them autonomously. Also, it protects the manufacturer's employees from fire catastrophe by warning them using a buzzer and notification. The system comprises two main parts, sensing and actuation. The sensing part consists of three subsystems that measure temperature and humidity, water flow, and flame. The actuation part consists of a water pump, light, and fan. A powerful user interface is developed based on the Blynk platform. The proposed system controls the water pump by sensing water flow autonomously. In addition, based on a fire detected, a protection system is implemented to shut down the electricity from load in case of fire event occurs. Several testing scenarios were carried on to check the response of the system, and the result shows successful implementation of the proposal to handle different situations.
IoT cloud based noise intensity monitoring system
Authors: Fatema Tashfat , Hakim Md. Azizul , Khan Mim Tanjila , Jahan Mitu Mushrat , Paul Bijan
Published: January 2023

According to a survey published by the United Nations Environment Program (UNEP) last month, Dhaka, Bangladesh’s capital, is the world’s noisiest metropolis. Dhaka is consistently ranked as one of the most polluted cities in the world. The World Health Organization (WHO) has set a noise intensity limit of 55 decibels for a certain region. Dhaka, on the other hand, was determined to be twice as loud, at 110 to 132 decibels. As many as 66 percent of traffic cops work on the road to control traffic, and this high noise intensity noise is causing them hearing and sleeping problems on a daily basis. Furthermore, loud noises can increase blood pressure and pulse rates, produce mental stress, and interfere with amusement and personal interactions. Keeping all of this in mind, we designed a real-time noise pollution monitoring system that will assist in conducting experiments in this type of environment by evaluating noise intensity and automatically sending data to a IoT cloud-based platform.
Virtual machine tree task scheduling for load balancing in cloud computing
Authors: Kummar Maurya Santosh , Malik Suraj , Kumar Neeraj
Published: January 2023

The increasing number of publications towards cloud computing proves that much research and development has been done, especially for task scheduling. Organizations are eager to get more customized technology to run the most smoothly in the provision of visual cloud services for fruity users. As the circumstances of Covid indicate to technology that everyone should run digitally, the workload on machines increased. For workload solutions, organizations are trying to balance the situation with the successful operation of cloud services to use appropriate services/resources. Nevertheless, the issues are still to be resolved by researchers, so we respect all my friends who are putting a lot of effort into developing new techniques. A proposed paper is showing a new collation with the load balancing factor by implementing quality of service (QoS) and virtual machine tree (VMT). A CloudSim toolkit will then be used to compare them. A tree structure graph is included in the VMT algorithm to schedule tasks with the appropriate distribution on each machine. The QoS algorithm performs the task of scheduling based on the service required by the user with the best quality and satisfies the user.
Personal identification using lip print furrows
Authors: Afif Anai Tamara , S. Mersal Samira , M. Mostafa Mostafa-Sami
Published: January 2023

There are common techniques for personal identification such as fingerprint recognition, face recognition, and iris recognition. In this paper, we suggest a new method for personal identification using lip print furrows. This method will be useful in forensics services. This study aims to identify people by their lip print patterns that are unique for each person. Lip print features are extracted from the lip print images by using the vertical Sobel operator, diagonal ±45 lines, and hough transform. A lip print pattern was formed for each person containing only the furrows (the extracted features) that were extracted from 3 lip print images for that person. The correlation coefficients and the mean squared error (MSE) are provided and passed to the support vector machine (SVM) for the classification process. The suggested method gives good results. A comparison between the results of the proposed method and other methods was presented.
Discriminative analysis of wavelets for efficient medical image compression
Authors: Sivaraman Deepa , Jebanazer Jeneetha , Balasubramanian Bhuvaneswari
Published: January 2023

Critical diagnostic information inferred using state of the artradiology techniques helps radiologists in determining the severity of diseases and hence suggest suitable treatment procedures. As a result, dealing with medical image compression necessitates a trade-off between good perceptual quality and high compression rate. The objective of this work is twofold, i) to investigate the effect of increasing the number of encoding loops on medical image compression parameters, and ii) to determine the most suitable wavelet for medical image compression. Haar, Daubechies, Biorthogonal Demeyer, Coifletand Symlet wavelets are used for comparison. Six different sets of medical images are used for testing and from the results obtained it is observed that increasing the number of encoding loops results in better compression parameters but increasing beyond 9 has no significant effect on compression parameters and thus the optimum choice for the number of encoding loops is 9. From the second analysis it is observed that changing the type of wavelets used has no significant effect on the compression parameters.
SDSFLF: fault localization framework for optical communication using software digital switching network
Authors: Raju Chitra , Rajagopal Sudarmani , Venusamy Kanagaraj , Suriyan Kannadhasan , Alagarsamy Manjunathan
Published: January 2023

Optical network is an emerging technology for data communication inworldwide. The information is transmitted from the source to destination through the fiber optics. All optical network (AON) provides good transmission transparency, good expandability, large bandwidth, lower bit error rate (BER), and high processing speed. Link failure and node failure haveconsistently occurred in the traditional methods. In order to overcome the above mentioned issues, this paper proposes a robust software defined switching enabled fault localization framework (SDSFLF) to monitor the node and link failure in an AON. In this work, a novel faulty node localization (FNL) algorithm is exploited to locate the faulty node. Then, the software defined faulty link detection (SDFLD) algorithm that addresses the problem of link failure. The failures are localized in multi traffic stream (MTS) and multi agent system (MAS). Thus, the throughput is improved in SDSFLF compared than other existing methods like traditional routing and wavelength assignment (RWA), simulated annealing (SA) algorithm, attackaware RWA (A-RWA) convex, longest path first (LPF) ordering, and biggest source-destination node degree (BND) ordering. The performance of the proposed algorithm is evaluated in terms of network load, wavelength utilization, packet loss rate, and burst loss rate. Hence, proposed SDSFLF assures that high performance is achieved than other traditional techniques.
Effects of wood texture and color on aesthetic pleasure: two experimental studies
Authors: Dai Zetian , Xue Juan , Wang Shoushan
Published: January 2023

The texture and color on wood are key factors that influence an individual's perception of it. However, little research has been done to confirm what kind of pattern in textures and colors are more likely to evoke individual aesthetic pleasure. Therefore, twenty-four decorative wood from northern China were selected, identified, and quantified in their colors with a CR-5 Colorimeter. We picked out eight kinds of wood with optimal texture characteristics through feature-fusion wood grain recognition (FWGR) and enhanced the texture features with photoshop in VR space. The result show that, in the color dimension, woods in the hue range of 20-25 and saturation of 65-75 were considered beautiful for individual perception of aesthetic. In the texture dimension, the size of the space affects the individual's preference for texture. When the pattern of the wood ray is continuous and clear, the individual's perception of its fluidity is enhanced; while for the fuzzy and interrupted pattern of the wood ray, the individual does not follow the fluidity of the line but focuses on the overall uniformity.
Automation irrigation system using arduino for smart crop field productivity
Authors: Alagarsam Manjunathan , Devakadacham Sterlin Rani , Subramani Hariharan , Viswanathan Srinath , Johnmathew Jazizevelyn , Suriyan Kannadhasan
Published: January 2023

Agriculture is essential to the prosperity of agricultural countries like India. Thus, the suggested strategy is to use automation and internet of thing (IoT) technology to make agriculture smart. Applications enabled by the IoTs include irrigation decision assistance, crop growth monitoring and selection, and more. an Arduino-powered technology that boosts agricultural productivity. This study's main goal is to find the least quantity of water necessary to grow crops. Most farmers squander a lot of time on the fields rather than concentrating on the water that plants have access to at the right moment. The suggested system determines the required amount of water based on the data obtained from the sensors. Two sensors provide data on the soil's temperature, humidity, amount of sunlight each day, and soil temperature to the base station. The suggested systems must determine the amount of water required for irrigation based on these criteria. The system's main benefit is the use of precision agriculture (PA) in conjunction with cloud computing, which will maximise the use of water fertilisers while maximising crop yields and also assist in determining field weather conditions.
Águas da discórdia: a transposição das águas do Rio São Francisco e as mudanças de curso da missão indigenista católica
Authors: Rufino Marcos Pereira
Published: January 2023

A atividade missionária católica direcionada aos índios esteve, a partir da fase inaugurada pela criação do Conselho Indigenista Missionário (Cimi), nos anos de 1970, voltada prioritariamente para o tratamento das questões relativas aos direitos indígenas, afirmados a partir de princípios irredutíveis e inegociáveis. Nos últimos anos, todavia, percebemos uma gradativa reorientação dessa atividade para a incorporação de questões ambientais na pauta indigenista da missão. Neste artigo, discuto o caso da transposição do Rio São Francisco e suas controvérsias, e as possibilidades que este caso nos oferece para repensar as práticas contemporâneas da atuação da Igreja Católica junto aos povos indígenas no país.