bluuebunny/crossref_metadata_2025 huggingface dataset:
Mulheres intérpretes do Brasil
Authors: Arboleya Arilda , Galetti Camila Carolina Hildebrand , Guebert Caroline Aparecida , Franco Emilly Gabriela Menezes , Costa Hilton
Published: June 2022

Ao longo do curso do desenvolvimento sócio-histórico e acadêmico nacional, as intelectuais brasileiras produziram diversos trabalhos de interpretação do Brasil que, pela rotina de apagamentos e invisibilizações propiciadas e naturalizadas pela engenharia patriarcal, foram marginalizados na construção dos cânones do Pensamento Social. Este Dossiê “Mulheres intérpretes do Brasil” se propõe a discutir alguns desses modais que não lograram consagração na disputa da narrativa explicadora da nação de suas épocas, ponderando acerca de seus temas e recortes, de suas formas e estratégias, de suas singularidades, barreiras e potencialidades.
Modeling and Role-Modeling Theory on Stunting Children in the Perspective of Philosophy
Authors: Alifatin Aini
Published: June 2022

Stunting, during the Covid-19 pandemic, is increasingly becoming a big problem in the world, especially in poor and developing countries. Observational studies have shown that stunting is associated with poor nutrition, especially a plant-based diet, inflammation, caused by infection, enteric dysfunction, an environment with clean water, inadequate sanitation and hygiene (WASH), and endogenous inflammation associated with excess adiposity. This causes nutritional interventions to be often unsuccessful (Kemenkes RI, 2018).The government intervenes to reduce stunting to the target party, which is divided into two categories. The first category is specific nutrition intervention, namely monitoring children under five at the posyandu, giving immunizations, giving vitamin A, giving Supplementary Foods (PMT), and others. The second category is sensitive nutrition interventions, namely the provision of drinking water and proper sanitation, postnatal family planning (KB) services, providing information related to stunting, food social assistance, conditional cash assistance, and others. (KEMEN-PMK, 2018). WHO states, that the impact of stunting can be divided into short-term and long-term impacts. The short-term impacts are; increased incidence of morbidity and mortality; cognitive, motor, and verbal development in children is not optimal; and increased healthcare costs. While the long-term impact; Posture that is not optimal as an adult (shorter than usual); Increased risk of obesity and other diseases; The decline in reproductive health; Less than optimal learning capacity and performance during school years; and Low productivity and work capacity (Kemenkes RI, 2018). The nursing goal is to help people achieve quality, holistic health. Implementation of Modeling and Role Modeling Theory is an option in implementing nursing care for children with stunting. “Modeling” is gaining an understanding of the client’s world from the client’s perspective. That is to build a “model” of the client’s worldview. “Role‑Modeling” is based on the assumption that all humans want to interact with others, they want to carry out selected roles in society. Role-Modeling is using the client’s model of the world to plan interventions that meet his or her perceived needs, grow, develop and heal. Role-Modeling requires that we aim to build trust, promote a positive orientation and a sense of control, affirm strengths and set specific mutual goals.
“And I commit to giving good masters to the province”: Abílio César Borges and the rehabilitation of the Bahia Teacher
Authors: Almeida Cíntia Borges de , Silva Marcelo Gomes da , Bonfim Raquel Freire
Published: June 2022

The purpose of this article analyzed aspects of the ideal education, present elements in the speech of Abílio César Borges, through his proposal to reform education, as the General Director of Studies, with special attention to his proposals to respect teaching work. Through historical method, documentary research is anchored in the Report on Public Instruction of the Province of Bahia, in 1856. The methodological operation took place using the discourse analysis category, based on Foucault (2013; 2021); operating with the concept of intellectual, by Sirinelli (2003); in dialogue with Saviani (2000), Gondra and Sampaio (2010) and Alonso (2015) to problematize Abílio's trajectory in the historical-educational field.The Report, source and object of analysis, allowed to capture data concerning provincial public education, as well as a range of representations of the debates of the time, through patterns and perspectives that made up an ideal of education and civility.
Aspirin May Be a Suitable Prophylaxis for Patients with a History of Venous Thromboembolism Undergoing Total Joint Arthroplasty
Authors: Ludwick Leanne , Shohat Noam , Van Nest Duncan , Paladino Joseph , Ledesma Jonathan , Parvizi Javad
Published: June 2022

Background:

In recent years, aspirin has become a popular agent for venous thromboembolism (VTE) prophylaxis following total joint arthroplasty (TJA). Yet patients with a history of VTE are often given more aggressive prophylactic agents because of their increased baseline risk. The purpose of this study was to assess whether aspirin is an effective prophylactic agent in patients with a history of VTE.

Methods:

This was a single-institution, retrospective cohort study. The electronic clinical records of 36,333 patients undergoing TJA between 2008 and 2020 were reviewed. Data on demographic characteristics, comorbidities, intraoperative factors, and postoperative complications were collected. A propensity score-matched analysis was performed, as well as a multivariate regression analysis to account for confounders.

Results:

Of the 36,333 patients undergoing TJA, 1,087 patients (3.0%) had a history of VTE and were not receiving chronic non-aspirin. The risk for subsequent VTE was significantly higher (p = 0.03) in patients with a history of VTE (1.4%) compared with patients without prior VTE (0.9%). However, the incidence of VTE was not significantly lower (p = 0.208) in patients with a history of VTE who received aspirin (0.4%) compared with patients who received other VTE prophylaxis (1.5%). Propensity score matching showed no difference in VTE rates between the 2 groups (2.2% compared with 0.55%; p = 0.372). In a regression analysis accounting for VTE risk, the administration of aspirin was not associated with an increased risk for subsequent VTE (adjusted odds ratio, 0.32 [95% confidence interval, 0.02 to 1.66]; p = 0.274).

Conclusions:

Our findings suggest that, although patients with a history of VTE have an increased baseline risk for subsequent VTE, aspirin may be a suitable VTE prophylaxis in this group of patients.

Level of Evidence:

Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Simulated Herbicide Spray Retention on Floating Aquatic Plants as Affected by Carrier Volume and Adjuvant Type
Authors: Mudge Christopher R. , Getsinger Kurt D. , Sperry Benjamin P.
Published: June 2022

Foliar delivery of herbicides is a common means for plant management in aquatic environments. Though this technique is decades old, little is known about vegetative spray retention relative to this application method. A more complete understanding of maximizing herbicide retention could lead to improved plant management while simultaneously decreasing pesticide load in aquatic environments. Therefore, outdoor mesocosm experiments were conducted in 2020 to evaluate the effect of adjuvant type on foliar spray retention in waterhyacinth [Eichhornia crassipes (Mart.) Solms]. Additionally, the effect of carrier volume on spray retention in waterhyacinth, waterlettuce (Pistia stratiotes L.), and giant salvinia (Salvinia molesta D.S. Mitchell) was documented. Spray deposition did not differ among the nine adjuvants tested; however, spray retention was reduced 6% to 11% when an adjuvant was excluded from the spray solution. The effect of carrier volume on spray retention in waterhyacinth, waterlettuce, and giant salvinia was also investigated. Decreases in spray retention were most sensitive to increased carrier volume in waterhyacinth, followed by giant salvinia and waterlettuce. Among species, spray retention potential, as determined by intercept estimates, was greatest in waterlettuce and giant salvinia regardless of carrier volume. Asymptotes estimates for waterhyacinth, waterlettuce, and giant salvinia were 33%, 46%, and 79% spray retention, respectively. In other words, spray retention was the lowest and remained relatively constant at these values for the high carrier volumes tested (935 and 1,870 L ha⁻¹), which were likely due to the presence of pubescence on leaves and flatter leaf architecture represented by waterlettuce and giant salvinia compared to the glabrous vertical leaves of waterhyacinth. Future research will evaluate these concepts under field condition.
Use of Cryotherapy to Treat Obstructing Papilloma of an Accessory Tracheal Bronchus - Case Report
Authors: Adams Alexandra , Steiner Federico A
Published: June 2022

Background:
Tracheal papillomatosis is a relatively rare condition with limited data on successful treatment modalities. To our knowledge, this is the first report to describe a papilloma arising from an accessory bronchus. Furthermore, this case report demonstrates successful treatment with clinical and patient-centered improvements after use of Spray Cryotherapy
Case Presentation:
A 71-year-old woman presented with one year history of recurrent fevers and intermittent hemoptysis. Imaging and video bronchoscopy revealed an obstructing papilloma of an accessory tracheal bronchus to the right upper lobe. She was treated with debridement followed by multiple cryotherapy treatments resulting in resolution of her symptoms and post-obstructive pneumonia on imaging.
Conclusions:
This case report not only supports existing literature on the use of cryotherapy for airway diseases but also presents a unique form of obstructing papilloma confined to an accessory bronchus.
Human iPSC-Derived Neural Stem Cells with ALDH5A1 Mutation as a Model of Succinic Semialdehyde Dehydrogenase Deficiency
Authors: Chen Xiaodan , Peng Minzhi , Cai Yanna , Zhou Chengcheng , Liu Li
Published: June 2022

Background: Succinic semialdehyde dehydrogenase deficiency (SSADH-D) is an autosomal recessive gamma-aminobutyric acid (GABA) metabolism disorder that can arise due to ALDH5A1 mutations, resulting in severe, progressive, untreatable neurodegeneration. The SSADH-D is primarily studied using simplified model symptoms such as HEK293 cells overexpressing genes of interest, but such overexpression can result in protein aggregation or pathway saturation that may not be representative of actual underlying disease phenotypes. Methods: We utilized a CRISPR/Cas9 approach to generate human iPSC cell lines bearing ALDH5A1 mutations. Through screening, two different mutant cell lines, namely NM_001080.3: c.727_735del (p.L243_S245del) and NM_001080.3: c.730_738del (p.A244_Q246del) were obtained. Then, we induced iPSCs to neural stem cells and analyzed the characteristics of ALDH5A1 mutations in stem cells. Results: The hiPSC and NSC cell lines presented typical stem cell-like morphology. We found exciting changes in ALDH5A1 expression and GABA accumulation by comparing different cell lines. In addition, we found that the mutant cell lines had a splicing variant by analyzing the cDNA between the wild-type and the mutant cell lines. Conclusions: iPSC represents a promising in vitro model of SSADH-D that can be used to study early central nervous system developmental alterations and pathogenic mechanisms.
Cutaneous Toxic Effects in tumor patients treated with Programmed Cell Death Protein-1 checkpoint inhibitors and/or Programmed Death-Ligand 1 checkpoint inhibitors and its association with survival: a systematic review and meta-analysis
Authors: Zhao Fangmin , Zhu Junjing , Shao Tianyu , Chen Shuyi , Zhang Gaochenxi , Shu Qijin
Published: June 2022

Objective
To systematically review the cohort studies about the relation between immune-related Cutaneous Adverse Events(irCAEs) and clinical benefit in patients treated with Programmed Cell Death Protein-1(PD-1)/Programmed Death-Ligand 1(PD-L1) inhibitors through meta-analysis.
Methods
PubMed, Embase, Cochrane database, China National Knowledge Infrastructure, Wanfang Database of China Science Periodical Database and Chongqing VIP were searched for cohort studies from inception to 1 November 2020. The primary outcomes were objective response rate (ORR), progression-free survival (PFS) and overall survival (OS). Complete response (CR), partial response (PR), stable disease (SD), and progressive disease (PD) were examined as secondary outcomes. A pooled relative risk (RR) and hazard ratio (HR) with 95% confidence intervals (CI) were calculated.
Results
Nine studies (2105 participants) were included. Compared with non-irCAEs patients treated with PD-1/PD-L1 inhibitors, the ORR of patients with irCAEs was higher (RR 2.38, 95% CI 1.91 to 2.98). Patients occurred irCAEs were more likely to report CR (RR 3.68, 95% CI 0.67 to 20.14), PR (RR 3.11, 95% CI 1.95 to 4.96), and SD (RR 1.11, 95% CI 0.79 to 1.55), and less likely to get PD (RR 0.39, 95% CI 0.19 to 0.80). For survival data, irCAEs development was significantly associated with both PFS (HR 0.37, 95% CI 0.29 to 0.48) and OS (HR 0.50, 95% CI 0.42 to 0.60).
Conclusions
The occurrence of irCAEs was associated with a lower risk of tumor progression or death. Awareness of irCAEs is important as an indicator of robust antitumor immunity and associated improved survival.
Systematic review registration:
PROSPERO CRD42021250251.
Health Image Generation Technology Of Oilfield Distribution Network Considering Equipment Health Index And Operation And Maintenance Strategy
Authors: yang yang
Published: June 2022

A comprehensive grasp of the health status of existing distribution equipment and networks is the need of daily operation and maintenance management of distribution network and improvement of efficiency, the starting point of intelligent distribution network construction, and the cornerstone of all modern distribution technology research and application (energy internet, big data, cloud computing, Internet of Things). In order to solve the problems of state detection, power system efficient planning, operation and maintenance, etc. This paper selects the evaluation indexes suitable for smart grid from the aspects of safety, economy, reliability and environmental protection, and establishes a comprehensive evaluation index system of smart distribution network health, which divides the health state of oilfield distribution network into health, sub-health, general defects and serious defects. At the same time, this paper puts forward a generation technology of distribution network health degree portrait based on analytic hierarchy process and entropy weight method. In this paper, the health index is obtained by weighting the characteristic key quantity through the health degree evaluation method. In the selection of the key characteristic quantity, the line loss rate, power factor and line voltage are selected as the key characteristic quantity, and three indexes of safety, economy and reliability are taken as the standard. First, the entropy weight method was used to calculate the weight of the key feature quantity, then the health grade G was determined according to the key feature factors, and finally the health grade H was determined by the weighting of each factor. Dividing different health levels into different colors can eventually generate a straight line of health portraits at different times and days.
A Battery-Less hybrid in-tire pressure monitoring SoC for road vehicles using Adaptive Bayesian System and optimized wireless communication model
Authors: Vasantharaj A , Nandhagopal N , Murugesan Ramya , Mathew O Cyril
Published: June 2022

A tire-pressure monitoring system (TPMS) monitors air pressure present inside the pneumatic tires on automobiles. It reports the driver about the real-time air pressure of the tire by using easy low pressure warning light or a pictorial display. This research paper proposes a battery less hybrid TPMS SoC for road vehicles. This proposed hybrid TPMS calculates the pressure for only one tire, in order to evaluate the pressure of remaining wheels by utilizing the available sensors. The TPMS consists of two phases which are: data fusion and wireless transmission link. In the data fusion phase, the adaptive bayesian model is introduced for data fusion to enhance the accuracy value of pressure and temperature calculates in the TPMS. This adaptive Bayesian system estimation is utilized to fuse the multi-sensor data to minimize the uncertainty of the calculation and it enhance the system accuracy by reducing the data redundancy. It also deals with the imprecision of sensory assessment because of the occurred noise in the environment and feasible malfunction of hardware. In the second phase, the wireless transmission link consist of transmitter and receiver. To establish the reliability of the wireless communication method, we construct in tire data transmitter and receiver. It proceed the data communication link to the transmitter and the receiver to transfer and receive some needed information about the pressure and temperature. The main objective of this proposed battery less hybrid TPMS is to reduce the core power and effectively enhance the performance of SoC of TPMS. The performance metrics which are considered in this research such as: measurement of fusion errors and sensors, utilization of power in the pressure and temperature sensor, the transmitter phase noise and the output spectrum, the proposed method area, efficiency, frequency and output power are evaluated prove the effectiveness of the proposed battery less hybrid TPMS Soc.
Non symmetry of the function ζ(s)/s
Authors: OUKIL Walid
Published: June 2022

We prove that $\frac{\zeta(s)}{s} \neq\overline{\Big(\frac{\zeta(1-s)}{1-s}\Big)}$ for every $\Re(s)\in(0,\frac{1}{2})$ and $\Im(s)>0$, where $\zeta$ is the Riemann Zeta function. In the end of the paper, we give a discussion about the Riemann hypothesis.
CNN Technique For Detecting Alzheimer’s Disease by using MRI Images
Authors: Jathinsai Dronavalli , Narisetti Suhas , Pilla Adi Vishnu , P Sasi kumar
Published: June 2022

Alzheimer’s Disease(AD) is very common neurological diseases these days. Alzheimer’s is one such gradual disorder that destroys memory and other significant mental functions that leads to dementia. It is necessary to detect and treat it in the initial stages itself in order to avoid any major disintegration. Using normal medical methods AD is very difficult to detect, So they used various classifications using MRI images to detect. In order to get better result, Image acquisition and pre-processing has been done. Over these years there are several approaches to detect and treat the brain diseases, now as the technology progressing rapidly this project has come up with an idea to integrate deep learning techniques to detect and understand the severity of brain’s condition of patient.
Stochastic Model Predictive Control Strategy with Short-term Forecast Optimal SOC for a Plug-in Hybrid Electric Vehicle
Authors: Lin Xinyou , Chen Xiankang , Xu Xinhao
Published: June 2022

Both the stochastic traffic information and State of Charge (SOC) are great impact on the performance of the plug-in parallel hybrid electric vehicle (PHEV). The application of velocity prediction offers the forthcoming trip information directly to estimate the driving power and arrange the SOC. To address this issue, a Stochastic Model Predictive Control (SMPC) based energy management strategy ( EMS) considering short-term forecast optimal SOC is proposed. Firstly, a multiple linear regression of engine and battery is developed for SMPC oriented application, respectively. Then, the velocity prediction model is developed based Markov Chain and the reference SOC optimized by Dynamic Programming (DP) using the forthcoming information. On this basis, the SMPC based EMS with the short-term optimal SOC is constituted. Finally, the various prediction horizon and driver styles are discussed to validate the proposed strategy. The normal MPC and the DP are used as benchmark strategies for comparison to evaluate the evolution of short-term optimal SOC and performance of SMPC based EMS. The test results indicate that the SMPC with the short-term optimal SOC made it possible to promote the EMS with capable of significantly improving the fuel economy of the plug-in PHEV.
Does new-type urbanization curb haze pollution? A case study from China
Authors: Yang Shuwang , Liu Shanshan , Wu Ting , Zhai Ziyu
Published: June 2022

The rapid urbanization process has led to a high concentration of population and economic activities in urban space, thus leading to severe environmental pollution. The concept of new-type urbanization has been proposed in China to combat the pollution associated with urbanization, whereas little literature has focused on correctly identifying the impact and its influencing mechanism of new-type urbanization on haze pollution to improve the quality of urban development. Therefore, this study analyzed the theoretical mechanism of the impact of new-type urbanization on haze pollution, uses Chinese provincial-level panel data from 2007 to 2018, and employed a STIRPAT model with interaction effects for empirical testing. The results found that new-type urbanization significantly reduced haze pollution levels nationwide and in the central and western regions during the study period. In terms of the influencing mechanism, new-type urbanization reduced haze pollution by optimizing the level of intensive urban land use, upgrading the industrial structure and enhancing technological innovation. However, the influencing mechanism was regionally heterogeneous. This research provides a theoretical basis for better implementation of new-type urbanization construction and effective promotion of green and sustainable urban development.
Effects of dry season supplementation of Calliandra calothyrsus leaf-meal mixed with maize-bran on dairy cattle milk productivity in the West Usambara Highlands, Tanzania
Authors: Maleko David Dawson , Msalya George M. , Mtei Kelvin M.
Published: June 2022

The dry seasons decline in milk production due to insufficient feed supply to dairy cattle poses a great challenge to sustainability of smallholder dairy production systems in Tanzania. Locally produced leguminous fodder tree leaf meals combined with maize bran provide a great potential for overcoming the dry season protein-energy deficit in the basal roughage feeds. This study evaluated the effects of dry season Calliandra calothyrsus (Calliandra) leaf-meal: maize-bran based protein-energy homemade supplementary ration (HSR) on milk production of lactating cross-bred dairy cows in the Western Usambara Highlands (WUHs), Tanzania. Complete randomized design was employed whereby four groups of 4 lactating dairy cows were subjected to four levels of HSR rationed at 0, 2, 4 and 6 kg/cow/day. The lactating cows which were not subjected to HSR supplementation (0 kg/cow/day) were left under farmers’ feeding practices as a control. HSR had significant effect on dry season milk yields (P < 0.001) whereby milk yields were 2.7, 4.5, 5.6 and 6.1 litres/cow/day for 0, 2, 4 and 6 kg HSR/cow/day, respectively. In addition, simulated year-round daily milk yields indicated that 4 and 6 kg HSR/cow/day would double the milk yields. Nevertheless, there was overall significant difference in the income to cost ratios (P = 0.02) whereby it was 0.50, 0.79, 1.06 and 1.09 for 0, 2, 4 and 6 kg HSR/cow/day, respectively. However, the income to cost ratios for 4 and 6 kg HSR/cow/day did not differ significantly (P < 0.05). In conclusion, if the dairy farmers in WUHs are to produce profitable milk amounts during the dry seasons the supplementation level of 4 kg HSR/cow/day to the basal diets is recommended.
Upper gastrointestinal bleeding related to an eroded gastrosplenic collateral lately after splenic artery embolization: a case report and review of the literature
Authors: Thillo Anna Van , Buyck Pieter-Jan , Gool Stijn Van , Croonen Cleo , Maleux Geert
Published: June 2022

Background
Upper gastrointestinal, non-variceal haemorrhage can be related to various etiologies, including peptic ulcer, neoplasm, gastritis, Dieulafoy lesions and other, rare underlying diseases. In this report, we present another, very rare etiology of arterial, gastric bleeding.
Case presentation
: A 49-year-old man presented with melena; gastroscopy revealed blood in the stomach without active bleeding source. Computed tomography angiography demonstrated a cluster of enlarged gastrosplenic arterial collaterals in the gastric wall and coils in the splenic artery, related to an embolization procedure 30-years ago for splenic trauma. Definitive treatment included catheter-directed glue embolization of the left gastric artery and the enlarged gastrosplenic collaterals. The postinterventional course was uneventful and no recurrence of upper gastrointestinal bleeding was noted after 6 months of follow-up.
Conclusions
Upper gastrointestinal bleeding associated with eroded gastrosplenic collaterals can be successfully treated with glue-embolization.
The abnormal expression of circ-ARAP2 promotes ESCC progression through regulating miR-761/FOXM1 axis-mediated stemness and the endothelial-mesenchymal transition
Authors: Xu Pei , Wang Lei , Liu Qingtao , Gao Pengkai , Hu Fengqing , Xie Xiao , Jiang Lianyong , Bi Rui , Ding Fangbao , Yang Qi , Xiao Haibo
Published: June 2022

Circular RNAs (circRNAs) belong to a novel class of noncoding RNA that gained more attention in human cancer pathogenesis. The role of circRNA in esophageal squamous cell carcinoma (ESCC) is largely unclear. Present investigation was to characterize new circRNAs regulating ESCC progression and explore the regulatory mechanisms in ESCC. In this study, circRNAs differentially expressed in ESCC and adjacent normal tissues were characterized via high-throughput sequencing. Then the differentially expressed circRNA between ESCC and adjacent normal tissues were investigated using Rt-qPCR. The role of circ-ARAP2 expression on tumor progression were detected in both in vivo and in vitro. Luciferase reporter assays were used to identify the relationships among circ-ARAP2, microRNA (miR)-761 and the cell cycle regulator Forkhead Box M1 (FOXM1). The result of the expression profile analyses regarding human circRNAs in ESCC demonstrated that circ-ARAP2 was up-regulated significantly in both ESCC tissues and cell lines. Downregulation circ-ARAP2 suppressed ESCC proliferation, tumor growth and metastasis inboth in vivo and in vitro. The data also suggested that miR-761 and FOXM1 were circ-ARAP2 downstream targets which were confirmed through luciferase reporter analysis. Overexpression of FOXM1 or inhibiting miR-761 restored ESCC cell proliferation and invasion ability after silencing circ-ARAP2. The study also found that circ-ARAP2 influenced the endothelial-mesenchymal transition (EMT) and cancer stem cells differently by regulating miR-761/FOXM1. In one word, the results demonstrated that abnormal circ-ARAP2 expression promoted ESCC progression by regulating miR-761/FOXM1 axis-mediated stemness and EMT.
Prevention of penehyclidine on postoperative nausea and vomiting in patients with thyroid surgery: a prospective, randomized, double-blinded comparison
Authors: Lu Ting , Li Rongrong , Sun Jiacheng , Chen Jing
Published: June 2022

Backgroud: Postoperative nausea and vomiting (PONV) is one of the most common complication after thyroid surgery under general anesthesia. Propofol-based total intravenous anesthesia (TIVA) has been documented to prevent PONV in patients undergoing thyroid surgery. Penehyclidine, an anticholinergic agent with an elimination half-life over 10 hours, is widely used as premedication to reduce glandular secretion. This study was to explore the preventative effects of penehyclidine with propofol based TIVA to single-TIVA on PONV in patients undergoing thyroid surgery.Methods: A total of 100 patients scheduled for thyroid surgery were randomly assigned into penehyclidine group or TIVA group. Propofol was used for TIVA in all patients. There were no patients who received premedication. Patients were administrated with 5ml of normal saline or 0.5mg of penehyclidin soon after anesthesia induction. The incidence of nausea and vomiting, severity of nausea, the requirement of rescue antiemetics, and adverse effects were investigated during the first 24 hours in 2 time periods (0-2 h and 2-24 h). Results: The overall PONV incidence during the 24 h after surgery was significantly lower in the penehyclidine group compared with the TIVA group (12% vs 36%, P < 0.005). Besides, the incidence of nausea and vomiting were significantly lower in the penehyclidine group compared with the TIVA group at 2-24 h after surgery. However, there was no significant difference between the two groups at 0-2 h after surgery.Conclusions: Penehyclidine with propofol based TIVA was more effective in PONV than TIVA, especially 2-24 h after thyroid surgery. Trial registration: https://www.chictr.org.cn/edit.aspx?pid=132463&htm=4 (Ref: ChiCTR2100050278, the full date of first registration: 25/08/2021).
MicroRNA-34a-5p promotes the progression of osteoarthritis secondary to developmental dysplasia of the hip by restraining SESN2-induced autophagy
Authors: Wang Jun , Sun Yanshan , Xu Meng , Wang Congcong , Liu Xiaoguang , Li Xiaopeng , Zhang Yimin
Published: June 2022

Osteoarthritis (OA), a late-stage complication of developmental dysplasia of the hip (DDH), is a key factor leading to further degeneration of joint function. Studies have shown that Sestrin2 (SESN2) is a positive regulator in protecting articular cartilage from degradation. However, the regulatory effects of SESN2 on DDH-OA and its upstream regulators still remain obscure. Here, we first identified that the expression of SESN2 significantly decreased in the cartilage of DDH-OA samples, with an expression trend negatively correlated with OA severity. Using RNA sequencing, we identified that the upregulation of miR-34a-5p may be an important factor for the decrease in SESN2 expression. Mechanistically, we showed that miR-34a-5p could significantly inhibit the expression of SESN2, thereby promoting the activity of the mTOR signaling pathway. We also found that miR-34a-5p significantly inhibited SESN2-induced autophagy. We further validated that knocking down miR-34a-5p in vivo resulted in significant increase of SESN2 expression and autophagy activity in DDH-OA cartilage. Our study suggests that miR-34a-5p is a negative regulator of DDH-OA, and may provide a new target for the prevention of DDH-OA.
Correlation between serum total bilirubin and survival in advanced cancer with obstructive jaundice after percutaneous biliary drainage
Authors: Zhang Fujun , Zhu Wenliang , Guo Huanqing , Hu Pan , He Xu
Published: June 2022

Purpose
The main purpose of our study was to evaluate the impact of a decreased proportion of total serum bilirubin after percutaneous transhepatic biliary drainage (PTBD) on survival and to identify prognostic factors associated with survival in patients with malignant obstruction jaundice (MOJ).
Methods
From July 2010 to February 2021, 269 patients with MOJ were included. Survival time and prognostic factors were analyzed by Kaplan–Meier curves and the Cox model. The cut-off value of a decrease in the proportion of total serum bilirubin level that predicted patient mortality was determined by receiver operating characteristic (ROC) curves.
Results
The overall median survival time after PTBD was 135 days (min13-max1276 days-95% IC:117–153). The overall survival (OS) improved from 95 days to 243 days when the procedure achieved functional success. Multivariate analysis demonstrated that functionally successful drainage and post-drainage treatment were independent positive prognostic factors, but the total bilirubin after drainage and tumor size were independent negative predictive values. The cut-off value of the proportional decrease in the total serum bilirubin level for predicting the clinical prognosis was 0.44.
Conclusions
Palliative care after drainage can prolong patient survival and improve their quality of life. A decreased proportion of total serum bilirubin after PTBD could be used to predict the survival prognosis in patients.
Sub-retinal pigment epithelium tubules in non- neovascular age-related macular degeneration
Authors: Fragiotta Serena , Parravano Mariacristina , Sacconi Riccardo , Costanzo Eliana , Geronimo Daniele , Prascina Francesco , Capuano Vittorio , Souied Eric H , Han Ian C. , Mullins Robert , Querques Giuseppe
Published: June 2022

Purpose
To describe a novel optical coherence tomography (OCT) signature resembling sub-retinal pigment epithelium (RPE) tubules (SRT) in non-neovascular age-related macular degeneration (AMD).
Methods
Patients suffering from non-neovascular AMD with complete medical records and multimodal imaging were retrospectively revised in three different tertiary care centers. Multimodal imaging included color fundus photograph, spectral-domain OCT (Spectralis, Heidelberg Engineering, Germany), fundus autofluorescence, OCT angiography (RTVue XR Avanti, Optovue, Inc., Fremont, CA).
Results
A total of 7 eyes of 7 patients with drusenoid pigment epithelium detachment (PED) were consecutively analyzed. The sub-RPE tubules appeared as ovoidal structures with a hyperreflective contour and hyporeflective interior appreciable in the sub-RPE-basal lamina (BL) space on OCT B-scan. The anatomical location of the sub-RPE formations was lying above the Bruch’s membrane in 5/7 cases (71.4%) or floating in the sub-RPE-BL space in 2/7 cases (28.6%). En-face OCTA revealed a curvilinear tubulation-like structure corresponding to SRT without flow signal.
Conclusions
Sub-RPE tubules represent a newly identified OCT signature observed in eyes with drusenoid PED. The presumed origin may include a variant of calcified structure or alternatively activated RPE cells with some residual BL or basal laminar deposits attracted to BrM for craving oxygen.
Prognostic Impact of Conversion Hepatectomy for Initially Unresectable Colorectal Liver Metastasis
Authors: Takamizawa Yasuyuki , Inoue Manabu , Moritani Konosuke , Tsukamoto Shunsuke , Esaki Minoru , Shimada Kazuaki , Kanemitsu Yukihide
Published: June 2022

Purpose: This study evaluated the prognostic impact of conversion hepatectomy in patients with initially unresectable colorectal liver metastasis (CRLM) and to identify prognostic factors after conversion hepatectomy.Methods: Correlations of conversion hepatectomy with relapse-free survival (RFS) and overall survival (OS) were retrospectively investigated in 554 consecutive patients who underwent hepatectomy for CRLM in 2000–2017. Prognostic factors after conversion hepatectomy were examined in multivariable analysis.Results: Five hundred and nine patients (92%) had initially resectable CRLM at the time of diagnosis and underwent hepatectomy (primary resection group) and 45 (8%) underwent conversion hepatectomy following chemotherapy (conversion group). The 5-year RFS was 30.0% in the primary resection group and 19.8% in the conversion group (p=0.042); the respective 5-year OS rates were 62.0% and 52.4% (p=0.253). Multivariable analysis did not identify conversion hepatectomy as a significant prognostic factor for RFS (hazard ratio [HR] 0.95, 95% confidence interval [CI] 0.65–1.38, p=0.787) or OS (HR 1.12, 95% CI 0.69–1.83, p=0.643). In the conversion group, multivariable analysis identified timing of liver metastases (synchronous: HR 3.14, 95% CI 1.20–8.24, p=0.020) and the preoperative CEA level to be independent prognostic factors for RFS (>5 ng/ml: HR 3.10, 95% CI 1.45–6.61, p=0.003) and OS (>5 ng/ml: HR 3.29, 95% CI 1.18–9.17, p=0.023).Conclusions: RFS and OS rates after conversion hepatectomy were not inferior to those after primary resection in patients with CRLM. Patients with a normal CEA level before hepatectomy can be expected to have a good long-term prognosis after conversion hepatectomy.
Heparin-modified acellular dermal matrix/chitosan-doped polydopamine nanoparticles composite sponge scaffold loaded with CGF: promoting full-thickness defect wound healing
Authors: Yang Lei , Chen Lianglong , Huang Chaoyang , Zhong Yu , Chen Yujia , Zhang Huihui , Zheng Zijun , Jiang Ziwei , Wei Xuerong , Peng Yujie , Huang Lei , Niu Libin , Gao Yanbin , Ma Jun
Published: June 2022

Background
Although acellular dermal matrix (ADM) and concentrated growth factor (CGF) are both used in regenerative medicine, CGF has been hampered by problems such as burst release, and ADM is only used as an outer dressing for wound healing. In this study, we aim to prepare composite scaffolds (CADMS-G-2-Hep) with good NIR photothermal response, antibacterial activity, and drug delivery ability by introducing polydopamine nanoparticles (PDA NPS) with excellent NIR photothermal conversion ability into ADM and chitosan (CS) interpenetrating network structure and heparinization modification.
Method
Firstly, a physical-chemical double cross-linked composite network was constructed by using chemical cross-sections and the mutual entanglement of ADM and CS chains under freezing conditions. Secondly, the heparinization modification made the composite scaffold with good biocompatibility and cell/tissue affinity, significantly promoting cell adhesion and proliferation and achieving adequate fixation and slow release of CGF. Finally, PDA-NPS have excellent NIR photothermal conversion ability and can significantly promote the survival of autologous skin grafts in rats. One-way ANOVA with Bonferroni posthoc analysis was used to determine whether a statistically, significant difference exists between groups.
Result
In vivo experiments, this composite biomaterial promoted angiogenesis, cell proliferation, and adhesion, improved skin survival of full-thickness skin defect wounds, reduced graft shrinkage and scar formation and promoted wound healing and tissue remodeling.
Conclusion
CADMS-G-2-Hep has the potential as a novel scaffold material capable of delivering CGF, which can promote full-layer skin defect healing through a one-step strategy.
Stochastic parameter-shift rule for quantum metrology with general Hamiltonians
Authors: Ho Le Bin
Published: June 2022

Recently, quantum metrology with multiplicative Hamiltonians has been proposed in the variational quantum algorithms, from which the estimation precision can be adaptively optimized via the variational circuits. Systems with general Hamiltonians, however, still lack these variational schemes. This work introduces a quantum-circuit-based approach for studying quantum metrology with general Hamiltonians. We present a stochastic parameter-shift rule for the derivatives of the evolved quantum state under the parameterized gates in the circuit, whereby the quantum Fisher information can be obtained. Here the parameters are those we wish to estimate. We find that our scheme can be executed in universal quantum computers under the family of parameterized gates. Moreover, in the examples of the magnetic field estimation, we show the consistency between the results obtained from the stochastic parameter-shift rule and the exact results, while the results obtained from the standard parameter-shift rule slightly deviate from the exact ones. Our work sheds new light on studying quantum metrology with general Hamiltonians using quantum circuit algorithms.
Methodology, Assessment and Application of Biotope Mapping for Urban Parks in China: A Case Study on Riverside Park, Yichang
Authors: Zhao Cong-cong , Yang Yu-qi , Hu Yuan-dong
Published: June 2022

China, like many other countries in the world, has declining biodiversity caused by urbanization. Urban parks are a patchwork of distinct biotopes and have significant conservation value for biodiversity. Biotope mapping is an essential tool for urban biodiversity conservation, ecological spatial planning and ecosystem management, however there are few studies on it in China. This study explores a practical scheme of biotope classification, assessment and application for urban parks. We updated a classification scheme which integrated vegetation structure to make it clearer and more appropriate for urban parks in factor selection and grade. To identify problems in the biotope, the assessment tool assessed biotope fragmentation and spontaneous vegetation diversity. The number of patches (NP), mean patch size (MPS) and fragmentation index (FI) were used to measure biotope fragmentation, and for species level we used the richness index and the Jaccard index. These methods were applied to Riverside Park, Yichang as a case study site to verify the applicability and explore methods for biodiversity conservation and restoration based on biotope mapping. The results show that this classification scheme has the potential to become a standard system for urban parks in China, according to the advantages of recognition of human activities and other species, wide applicability and easy learning. It is also shows that the evaluation method integreting fragmentation and diversity is feasible and reliable to identify the problems of biotope types, and practical strategies are developed according to the assessment results. Our findings provide guidance and reference for professionals on a new method to take urban biodiversity conservation and restoration from research to practice.
Evaluating Impact of Land Use and Land Cover Change under Climate Change on a Lake System
Authors: GUNACTI Mert Can , GUL Gülay ONUSLUEL , CETINKAYA Cem Polat , GUL Ali , BARBAROS Filiz
Published: June 2022

Persistent pressures that relate to nonstationary climate variations and land use/cover changes (LULCC) keep affecting water resources and their associated environmental services with increasing impact trends worldwide. Lake Marmara, located in Gediz River Basin in Western Turkey, is already considered among the environmentally degraded water resources while counted with a priority wetland due to historical habitats and ecosystem functions. The region is remarkably threatened to its extinction under the combined impacts of both climate and LULCC related concerns. While intensive agricultural practices around the region deplete the lake's inflow sources, low levels of the lake water provide breeding ground for various algae types and cause eutrophication and related massive fish population decreases, in a way restricting local communities' access to fundamental ecosystem services for their survivability. The study investigates the effects of LULCC in the example of Lake Marmara in an environmental scope and provides water balance modelling that is utilized to help examine hydrologic conditions of the lake. Future LULCC and water balance projections are also incorporated to evaluate probable views in near future ahead with the main target of providing a valuable tool for the decision and policy making processes.
Hypofractionated radiotherapy in intermediate-risk prostate cancer patients: long-term results.
Authors: Valeriani Maurizio , Staso Mario Di , Facondo Giuseppe , Vullo Gianluca , De Sanctis Vitaliana , Gravina Giovanni Luca , Pagliuca Milena Di Genesio , Osti Mattia Falchetto , Binfili Pierluigi
Published: June 2022

Background: To evaluate survival and toxicities outcomes in a series of patients with intermediate-risk prostate cancer (PCa) treated with hypofractionated radiotherapy (HyRT) + androgen deprivation therapy (ADT) with or without image guided radiotherapy (IGRT) and to investigate the impact of different variables.Methods: This is a multi-centric study. From January 2005 and December 2019, we treated 313 intermediate risk Pca patients (T2b–T2c or Gleason Score 7 or pre-treatment PSA 10 to 20 ng/mL) with HyRT. Patients received 54,75 Gy in 15 fraction in 5 weeks plus 9 months of neo-adjuvant, concomitant and adjuvant ADT with or without IGRT.Results: Median follow-up was 91.6 months (range 5.1-167.8 months). Median OS was not reached, the 8 and 10-year OS were 81.9 % and 72.4%, respectively. Median CSS was not reached, the 8 and 10-year CSS were 97.9 % and 94.5%, respectively. PSA at first follow-up <0.8 ng/ml was significantly related to better oncological outcomes (CSS, bRFS, LRFS, cPFS, MFS) in both univariate and multivariate analysis. After PS matching Grade 2-3 acute and cumulative late GU (p=0.153 and p=0.581, respectively) and GI (p=0.196 and p=0.925, respectively) toxicity were not statistically different in patients treated with or without IGRT.Conclusions: HyRT is effective and safe regardless of the use of the IGRT. PSA at first follow-up is an easy-accessible prognostic factor that may help the clinicians to identify patients who necessitate a treatment intensification.
Evidence of seasonal changes in air quality and occupation-specific variations in pulmonary function and haematological parameters among some workers in Enugu Southeast Nigeria
Authors: Ibeneme Sam Chidi , Ativie Rita Nkechi , Ibeneme Georgian Chiaka , Myezwa Hellen , Ezuma Amarachi Destiny , Nnamani Amaka , Ezeofor Salome , Nwankwo Maduabuchukwu Joseph , Ettu Theresa Ucheoma , Nwosu Akachukwu Omumuagwaula , Okoye Ifeoma , Fortwengel Gerhard
Published: June 2022

Background
Upsurge in cardiopulmonary dysfunctions in Enugu, Nigeria, involved mainly cement workers, automobile spray painters, woodworkers, and civil servants (cleaners) and was worsened in the dry season, suggesting the need for an occupation-specific characterization of the disease features and seasonal evaluation of air quality for prevention and management.
Methods
We conducted a randomized cross-sectional study of eighty consenting participants (in Achara Layout, Enugu), comprising 20 cement workers (39.50 ± 14.95years), 20 automobile painters (40.75 ± 9.85years), 20 woodworkers (52.20 ± 9.77years), and 20 cleaners (42.30 ± 9.06years). The air quality, some hematological (fibrinogen-Fc, and C-reactive protein-CRP), and cardiopulmonary parameters were measured and analyzed using ANCOVA, at p < 0.05.
Results
The dry season particulate matter (PM) in ambient air exceeded the WHO standards in the New layout [PM10 = 541.17 ± 258.72µg.m− 3; PM2.5=72.92 ± 25.81µg.m− 3] and the university campus [PM10 = 244 ± 74.79µg.m− 3 ; PM2.5=30.33 ± 16.10µg.m− 3], but the former was twice higher. The PM differed significantly (p < 0.05) across the sites. Forced expiratory volume at the first second (FEV1) (F = 6.128, p = 0.001), and Peak expiratory flow rate (PEFR) (F = 5.523, p = 0.002), differed significantly across the groups. FEV1/FVC% was < 70% in cement workers (55.33%) and woodworkers (61.79%), unlike, automobile painters (72.22%) and cleaners (70.66%). FEV1 and work duration were significantly and negatively related in cement workers (r=-0.46, r2 = 0.2116, p = 0.041, one-tailed). CRP (normal range ≤ 3.0mg/L) and FC (normal range-1.5-3.0g/L) varied in cement workers (3.32 ± 0.93mg/L versus 3.01 ± 0.85g/L), automobile painters (2.90 ± 1.19mg/L versus 2.54 ± 0.99g/), woodworkers (2.79 ± 1.10mg/L versus 2.37 ± 0.92g/L) and cleaners (3.06 ± 0.82mg/L versus 2.54 ± 0.70g/L).
Conclusion(s):
Poor air quality was evident at the study sites, especially in the dry season. Cement workers and spray painters showed significant risks of obstructive pulmonary diseases while woodworkers had restrictive lung diseases. Cement workers and cleaners recorded the highest risk of coronary heart disease (CRP ≥ 3.0mg/L). The similarity in Fc and CRP trends suggests a role for the inflammation-sensitive proteins in the determination of cardiovascular risk in cement workers and cleaners. Therefore, there are occupation-specific disease endpoints of public health interest that likewise warrant specific preventive and management approaches among the workers.