bluuebunny/crossref_metadata_2025 huggingface dataset:
Acreditación internacional: experiencia de la facultad de ingeniería de la Universidad Nacional de Colombia
Authors: Camacho Tamayo Jesús Hernán , Vega Herrera Jenny Marcela , Guzmán Pardo María Alejandra
Published: October 2024

La búsqueda de la excelencia educativa en el ámbito universitario ha llevado a instituciones de todo el mundo a someterse a procesos de acreditación internacional. Estos procedimientos no solo validan la calidad de los programas académicos, sino que también proporcionan una plataforma para la mejora continua y el reconocimiento global. En el contexto de la Facultad de Ingeniería de la Universidad Nacional de Colombia, después de varios procesos de acreditación con el Consejo Nacional de Acreditación Nacional (CNA) y los resultados positivos por parte de la evaluación externa, en el año 2014 se decidió iniciar con los esfuerzos para obtener la acreditación con el sello ABET. Luego de un arduo proceso, en el año 2019 se obtuvo la acreditación para el programa de Ingeniería Química y en 2020 para Ingeniería Eléctrica y Electrónica, con los aprendizajes obtenidos y reconociendo el interés de los egresados de la Facultad en ejercer su profesión en Europa, en 2019 se realizó un acercamiento para obtener la acreditación con el sello EUR-ACE, esto permitió que luego de una reflexión curricular, definición de resultados de aprendizaje en 2022 se obtuviera la acreditación internacional para los programas de ingeniería agrícola, ingeniería civil, ingeniería mecánica e ingeniería mecatrónica. La acreditación internacional no sólo válida la calidad de los programas académicos ofrecidos por la institución, sino que también ha promovido la alineación con estándares globales de excelencia. En el caso de la Facultad de Ingeniería de la Universidad Nacional de Colombia, la obtención de estas acreditaciones ha sido un proceso que ha implicado una rigurosa evaluación de sus programas, así como un compromiso institucional con la mejora continua y la innovación educativa. A lo largo de este trabajo, se exploran los distintos aspectos de la experiencia de la Facultad de Ingeniería en su búsqueda por la acreditación internacional. Se examinan los desafíos enfrentados, los procesos implementados para cumplir con los estándares establecidos, los beneficios obtenidos y las lecciones aprendidas a lo largo de este camino. Este trabajo busca ofrecer una visión integral y reflexiva sobre la importancia y el impacto de la acreditación internacional en el ámbito educativo y académico, con un enfoque específico en la experiencia de la institución.
Transformación de la Supply Chain Management: abordando la industria 4.0 y la planeación colaborativa mediante el pensamiento sistémico y el critical thinking
Authors: López Astudillo Andrés , Rodríguez Guzmán José Camilo
Published: October 2024

La Industria 4.0, corresponde a un movimiento que involucra tecnologías digitales avanzadas en los procesos logísticos y de relaciones, estructurando las cadenas de suministros. Con el objetivo plantear un escenario de discusión y generar una reflexión al lector con respecto los beneficios que ofrece la industria 4.0 y la planeación colaborativa, dentro de las cadenas de suministros, se desarrolló un análisis teórico de su aplicación. Este proyecto de investigación deja como resultado una metodología para abordar artículos científicos a partir de la construcción de macro mapas mentales, partiendo desde la lectura y análisis de los documentos hasta proponer integraciones de informaciones que aparentemente no tenían un grado de relación visible. De esta manera, consolidando una herramienta iterativa que se puede aplicar a cualquier contexto académico e investigativo y que a su vez fomenta la creatividad y actúa como una fuente de estructuración visual y de organización de ideas. Otro beneficio identificado, mediante esta metodología, es la aplicación de conocimientos que se habían adquirido en las fases tempranas de la carrera de ingeniería industrial y que no habían sido retomados nuevamente como un conjunto. Para llevar a cabo este cometido, se tomaron como base de lectura artículos científicos orientados a ambas temáticas. Una vez procesados los textos, se utilizó la metodología del pensamiento sistémico aplicando el arte de conectar, obteniendo de esta manera dos mapas sistémicos cada uno con 207 y 235 nodos respectivamente, en los que se abordan los aspectos teóricos e implicaciones prácticas de los artículos en cuestión, complementados con comentarios que resumen/aportan a secciones específicas de los mapas. En un segundo paso, la aplicación de Critical Thinking, mediante el contraste de información, la interconexión, la ampliación de nodos y la unificación de saberes, se logró consolidar un tercer gran mapa de 440 nodos que condensa y desarrolla, de una mejor manera, lo suministrado en los anteriores mapas y a la vez es complementado con los conocimientos de los autores y otros textos existentes de la literatura. Desde un punto de vista estructural, con este pensamiento se logró realizar las abstracciones de los elementos, de mayor relevancia, pertenecientes a los artículos, obteniendo una visión que da cuenta del funcionamiento global, características, factores determinantes y la inclusión de buenas prácticas en la industria 4.0 y la planeación colaborativa. A partir de este pensamiento, se propone el siguiente texto (siendo el resultado definitivo que se puede llegar en términos de conciencia y criticidad) en el que se aterrizan las ideas, conceptos y opiniones de la industria 4.0 y la planeación colaborativa, donde se puede llevar a cabo una extrapolación bajo el marco común, hacia el ámbito empresarial colombiano.
Aprendizaje de los procesos de producción a través del video juego Good Company
Authors: Calderón Matta Andrés , López Astudillo Andrés
Published: October 2024

La Industria 4.0, corresponde a un movimiento que involucra tecnologías digitales avanzadas en los procesos logísticos y de relaciones, estructurando las cadenas de suministros. Con el objetivo plantear un escenario de discusión y generar una reflexión al lector con respecto los beneficios que ofrece la industria 4.0 y la planeación colaborativa, dentro de las cadenas de suministros, se desarrolló un análisis teórico de su aplicación. Este proyecto de investigación deja como resultado una metodología para abordar artículos científicos a partir de la construcción de macro mapas mentales, partiendo desde la lectura y análisis de los documentos hasta proponer integraciones de informaciones que aparentemente no tenían un grado de relación visible. De esta manera, consolidando una herramienta iterativa que se puede aplicar a cualquier contexto académico e investigativo y que a su vez fomenta la creatividad y actúa como una fuente de estructuración visual y de organización de ideas. Otro beneficio identificado, mediante esta metodología, es la aplicación de conocimientos que se habían adquirido en las fases tempranas de la carrera de ingeniería industrial y que no habían sido retomados nuevamente como un conjunto. científicos orientados a ambas temáticas. Una vez procesados los textos, se utilizó la metodología del pensamiento sistémico aplicando el arte de conectar, obteniendo de esta manera dos mapas sistémicos cada uno con 207 y 235 nodos respectivamente, en los que se abordan los aspectos teóricos e implicaciones prácticas de los artículos en cuestión. Para llevar a cabo este cometido, se tomaron como base de lectura artículos y mapas. En un segundo paso, la aplicación de Critical Thinking, mediante el contraste de información, la interconexión, la ampliación de nodos y la unificación de saberes, se logró consolidar un tercer gran mapa de 440 nodos que condensa y desarrolla, de una mejor manera, lo suministrado en los anteriores mapas y a la vez es complementado con los conocimientos de los autores y otros textos existentes de la literatura. Desde un punto de vista estructural, con este pensamiento se logró realizar las abstracciones de los elementos, de mayor relevancia, pertenecientes a los artículos, obteniendo una visión que da cuenta del funcionamiento global, características, factores determinantes y la inclusión de buenas prácticas en la industria 4.0 y la planeación colaborativa. A partir de este pensamiento, se propone el siguiente texto (siendo el resultado definitivo que se puede llegar en términos de conciencia y criticidad) en el que se aterrizan las ideas, conceptos y opiniones de la industria 4.0 y la planeación colaborativa, donde se puede llevar a cabo una extrapolación bajo el marco común, hacia el ámbito empresarial colombiano.
El papel de la formación académica y la experiencia docente en la conceptualización del campo conceptual de la electrostática
Authors: López Garduza Felipe Augusto , Cabral Rosetti Luis Gustavo , Ramírez Díaz Mario Humberto
Published: October 2024

El aprendizaje de los conceptos de física a nivel universitario está influenciado por diferentes factores entre los que destaca el dominio del profesor de estos conceptos y su forma de enseñarlos. Este trabajo presenta el análisis de la comprensión del campo conceptual de la electrostática (fuerza electrostática, campo eléctrico y potencial eléctrico) en un grupo de ocho profesores del área de física de la Universidad Aeronáutica en Querétaro, México. El análisis considera su formación académica y su experiencia docente y, en particular, su experiencia impartiendo la asignatura de electricidad y magnetismo. La conceptualización fue evaluada mediante una evaluación diagnóstica diseñada para este fin, seguido de una entrevista semiestructurada. Durante la entrevista se profundizó sobre la forma en la que conceptualizan el campo conceptual y la forma y secuencia con la que abordan estos conceptos en clase. Las respuestas de los profesores no solamente proporcionan información sobre su conceptualización sino también sobre su apertura para cuestionarse esta conceptualización y en general, su apertura al aprendizaje continuo. El análisis muestra que tener formación académica en el área de física no es garantía de una correcta conceptualización y enseñanza de los conceptos. El factor que resulta ser relevante para este grupo de profesores es su experiencia impartiendo (y planeando) la asignatura, así como la disposición a participar en actividades de desarrollo profesional docente y su apertura a seguir aprendiendo independientemente del grado académico alcanzado.
Diseño de un juego serio para el aprendizaje de temáticas de brecha de género en la facultad de minas
Authors: López Roldán Mariana , Rojas López Miguel David , Londoño Vásquez Laura Marcela
Published: October 2024

El propósito de este estudio es desarrollar y validar un juego que aborde las brechas de género, una problemática relevante a nivel global que impacta significativamente en la educación y en áreas STEM, utilizando los juegos serios como herramienta de enseñanza-aprendizaje. Se comienza con una revisión bibliográfica para identificar los conceptos, elementos y variables que contribuyen a la existencia de la brecha de género en la sociedad y en entornos educativos, con un enfoque particular en la formación y comprensión de estas disparidades en áreas STEM entre estudiantes universitarios de la Facultad de Minas. Luego, se procede con el diseño del juego "Brechas" mediante una metodología específica para el diseño de juegos serios, que consta de tres fases: pre-diseño, diseño y testeo. La fase de testeo involucra encuestas de evaluación diseñadas para identificar y validar el aprendizaje proporcionado por el juego. Los resultados obtenidos de estas evaluaciones se presentarán en este documento.
Comparison of 2-D and 3-D Analysis of Running Kinematics and Actual Versus Predicted Running Kinetics
Authors: Martinez Caitlyn , Garbett Seth , Hiromasa Kristen , Jackson Rhandi , Miya Eric , Miya Michelle , White Joshua D , Baum Brian S , Reinking Mark F
Published: October 2024

Background

Providing clinicians with an accurate method to predict kinetic measurements using 2D kinematic motion analysis is crucial to the management of distance runners. Evidence is needed to compare the accuracy of 2D and 3D kinematic measurements as well as measured and estimated kinetic variables.

Purposes

The objectives of this study were to (1) compare 2D video analysis of running kinematics with gold standard 3D motion capture and, (2) to evaluate published equations which estimate running kinetics using 2D kinematic and spatiotemporal values and modify these equations based on study findings.

Design

Controlled laboratory study, cross-sectional design

Methods

Runners who averaged at least 20 miles per week were invited to participate. Athletes ran on an instrumented treadmill at their preferred training pace for a 6-minute warm-up. Markers were placed over designated anatomical landmarks on both sides of the pelvis as well as the left lower extremity. Subjects then ran at their preferred speed and kinematic data were recorded using both the 2D and 3D camera systems at 240 frames/second. Additionally, ground reaction forces were recorded at 1200Hz. 2D and 3D kinematic values were compared and published kinetic prediction formulas were tested. Linear regression was used to develop new prediction equations for average loading rate (AVG_LR), peak vertical ground reaction force (VERT_GRF), and peak braking force (PK_BRK). Paired t-tests were used to assess differences between the 2D and 3D kinematic variables and the measured (MEAS) and calculated (CALC) kinetic variables.

Results

Thirty runners (13 men and 17 women) voluntarily consented to participate in this study and the mean age of the participants was 31.8 years (range 20 to 48 years). Although significant differences existed, all 2D kinematic measures were within 2°-5° of 3D kinematic measures. Published prediction equations for AVG_LR and VERT_GRF were supported, but new prediction equations showed higher R2 for AVG_LR (0.52) and VERT_GRF (0.75) compared to previous work. A new prediction equation for PK_BRK was developed. No significant differences were found between the MEAS and CALC kinetic variables using the new equations.

Conclusion

Accurate predictions of kinetic variables can be made using spatiotemporal and 2D kinematic variables.

Level of Evidence

Level 2
Gestión presupuestaria en empresas privadas: principios y elaboración
Authors: Orellana Orellana Carlos Patricio , Orellana Orellana Edison Fernando , Pesantez Molina Wilson Geovanny
Published: October 2024

Este libro ofrece una guía exhaustiva sobre la gestión presupuestaria en empresas privadas, abordando la naturaleza, tipos y principios que rigen la elaboración del presupuesto. Con un enfoque práctico, busca satisfacer las necesidades tanto de estudiantes de administración como de profesionales en el campo empresarial.
Hezkuntza-berrikuntzarako esperientzia
Authors: Guerra Bilbao Nagore , Aizpurua Sanz Alaitz , Aróstegui Barandica Igone , Berasategui Sancho Naiara , Arribillaga Iriarte Ana , Jaureguizar Alboniga-Mayor Joana
Published: October 2024

Lan honetan, Euskal Herriko Unibertsitateko (UPV/EHU) 370 ikaslerekin egindako hezkuntza-berrikuntzako esperientzia bat aurkezten da. Kasuaren metodoan oinarrituta, diziplinarteko ikuspegi batetik eta ikaskuntza kooperatiboaren bidez, ezagutza teorikoa benetako egoerekin eta testuinguru profesionalekin erlazionatu nahi izan da. Kasuaren metodoa hezkuntza-beharrak dituen ikasle batean oinarrituta dago. Psikologia, Lehen Hezkuntza eta Gizarte Hezkuntzako ikasleak taldetan antolatu ziren eta kasua diziplinarteko ikuspegi batetik aztertu eta ebatzi zuten. Hainbat parte-hartzailek galdetegi batzuk bete zituzten kasuaren lanketarekin hasi aurretik eta ondoren, haien motibazioa eta ikaskuntza kooperatiboaren eta diziplinartekotasunaren inguruko pertzepzioa ezagutzeko. Emaitzetan ikusten denaren arabera, ezberdintasun esanguratsuak lortu ziren aldagai guztietan proiektuan parte hartu aurreko eta ondorengo puntuazioen artean. Beraz, lan honetan agerian geratzen da diziplinartekotasunean eta kasuaren metodoan oinarritutako hezkuntza-estrategien erabilerak hobetu egiten duela ikasleek ikas-kuntza kooperatiboari eta diziplinartekotasunari buruz duten pertzepzioa, bai eta haien motibazioan ere. as their motivation.
THE URGENCY OF DEVELOPING STUDENT’S HABITS OF MIND IN HIGH SCHOOL BIOLOGY LEARNING IN BANDUNG
Authors: Bariroh Ghurrotul , Rochintaniawati Diana , Nuraeni Eni , Nurjhani Kusumastuti Mimin
Published: October 2024

Habits of mind is one of the dimensions of long-term learning that allow productive actions to occur and can produce positive student character in solving problems in their lives. The importance of habits of mind is in contrast to the ability of habits of mind of students in one of the high schools in Bandung City which is still low. Based on this, the researcher aims to analyze the biology learning process carried out by teachers to further understand the factors that influence students' habits of mind. The method used in this research is quantitative descriptive. The sample was chosen using convenience sampling, so that 34 samples were obtained from class X students and biology teacher at one of the state high schools in Bandung City. The research results show that the low level of students' habits of mind is because teacher has not implemented how to develop students' habits of mind in classroom learning. Differentiated learning, student centers, reflection activities, and learning independence in using resources are the next researchers' recommendations for interventions to improve students' habits of mind.
INDUCTION OF DROUGHT RESISTANCE IN MELON (Cucumis melo L.) M15 WITH HORMOPRIMING BRASSINOSTEROID BASED ON MORFOLOGY, ANATOMY, AND PHYSIOLOGY ASPECTS
Authors: Rifki Arif Nur Rifki , Solichatun  , Pitoyo Ari
Published: October 2024

Melon productivity in Indonesia has been declining. Global climate change is affecting the productivity of melons. Long-term droughts have contributed to a reduction in plant growth and development. Hormopriming is an alternative to increase the germination and growth of melon plants by soaking seeds in a solution of plant growth regulators. Brassinosteroid can enhance germination and plant tolerance under drought conditions. The objective of this research is to examine the impact of brassinosteroid hormopriming treatment on the germination and growth of melon plants subjected to various degrees of drought stress. The study utilized a two-factor fully randomized design. The brassinosteroid concentrations used were 0, 0.05, 0.10, and 0.15 ppm. Media with different water capacities of 75%, 50%, and 25% Space Capacity (SC) were used to test drought stress resistance. Water capacities were examined using the gravimetric method. This study's findings suggest that treating melon plants with brassinosteroid variations can induce drought resistance in M15 melons. A brassinosteroid concentration of 0.15 ppm is the best concentration, as it can increase all parameters of plant growth and adaptation under each variation of water availability provided. The findings of this study can serve as a reference for melon cultivators constrained by dry land conditions to increase the efficiency of cultivation.
1,2,3-БЕНЗОТРИАЗОЛАТНЫЙ КЛАСТЕРНЫЙ КОМПЛЕКС (Bu4N)2[W6I8(N3C6H4)6]
Authors: Михайлов М.А. , Берёзин А.С. , Сухих Т.С. , Шевень Д.Г. , Компаньков Н.Б. , Соколов М.Н. , Тагильцев К.А.
Published: October 2024

Синтезирован новый 1,2,3-бензотриазолатный люминесцентный кластерный комплекс (Bu4N)2[W6I8(N3C6H4)6] (I), для сокристаллизата c 1,2,3-бензотриазолом, (Bu4N)2[W6I8(N3C6H4)6]·4(N3C6H5), установлена кристаллическая структура. По данным РСА, атомы вольфрама кластерного ядра {W6I8}4+ монодентатно координированы атомами 1-N азота 1,2,3-бензотриазолатных лигандов. Для порошкового образца нового соединения I выявлена яркая фосфоресценция c максимумом на 640 нм, значительный квантовый выход эмиссии (φ = 24%, τ = 266 мкс) в условиях контакта с кислородом воздуха является редким примером для октаэдрических кластерных комплексов типа [{M6X8}L6].
LIFE SKILLS AWARENESS: A STUDY OF HIGHER SECONDARY STUDENTS
Authors: Vemula Muttu , Lalramthari Christina
Published: October 2024

In today's rapidly evolving educational landscape, the primary focus has traditionally been on imparting knowledge and information. Student success was often measured by their ability to excel in examinations, achieve academic accolades, and pursue careers requiring specialized knowledge in a specific field. However, this paradigm is shifting. Education is no longer confined to textbooks and conventional classrooms. It is imperative for students to not only excel academically but also master the art of living.Life skills, often called soft skills or essential skills, are gaining prominence as an integral component of education. These abilities behaviors, and knowledge extend beyond academic disciplines and equipment for navigating the real- world problems. While academic knowledge remains undeniably important, life skills provide the foundation for leading successful, fulfilling lives. The realization that students need more than just scholastic achievement has led to a reinterpretation of educational goals. This research tries to examine the significance of life skills in education, their multifaceted nature, and their capacity to prepare students for success in a society that values practical knowledge, interpersonal skills, and adaptability as much as academic knowledge. By examining communication skills, problem-solving techniques, financial literacy, time management, emotional intelligence, and digital literacy, we will explore how these components of life skills are the cornerstone of overarching education.The study focused on Class XII students from two higher secondary schools in Aizawl District. A sample of 150 students (68 male, 82 female) were randomly selected from the population. A self-developed questionnaire was administered to the students during classroom visits. Responses were kept confidential. Statistical techniques such as mean, standard deviation, and t-tests were employed for data analysis and assess life skills awareness of each respondent.The analysis revealed that significant differences were found among male and female students in effective communication skills, accompanied by higher scores of male students. However, no significant differences were found between male and female students in critical thinking skills. Additionally, no noteworthy variations were observed among students from nuclear and joint families in any of the assessed life skills. While this study offers insightful information about life skills awareness among higher secondary students, more investigation or research is needed to explore the factors influencing the development of these skills in order to cultivate effective strategies for incorporating them into educational curricula. By emphasizing the importance of life skills, educational institutions can empower students to navigate the challenges of the 21st century and lead successful, fulfilling lives.
Perfil clínico y epidemiológico de una población pediátrica latinoamericana con vitíligo
Authors: Vargas-Navia Natalia , Velasquez Tafur Lina , Calderón Juan Camilo , Lozano Edgar Andrés , Arias David Andrés , Diaz Gómez Claudia Juliana
Published: October 2024

Introducción: El vitíligo pediátrico presenta diferencias clínicas respecto al vitíligo del adulto. Existen pocos estudios en América Latina que describan las características clínicas y epidemiológicas del vitíligo en niños y adolescentes.
Objetivo: Describir los datos clínico-epidemiológicos, demográficos, antecedentes familiares, factores desencadenantes y comorbilidades en una población infantil con vitíligo atendida en un hospital de referencia de Cali, Colombia.
Materiales y métodos: Estudio observacional descriptivo transversal. Se incluyeron setenta y cinco pacientes con diagnóstico de vitíligo entre 0 y 17 años de edad, quienes fueron atendidos en consulta externa entre julio de 2015 y marzo de 2019. Se analizaron datos clínico-epidemiológicos incluyendo el tipo de vitíligo más frecuente, edad de aparición. de la enfermedad, sexo, educación, antecedentes personales y familiares, factores relacionados, comorbilidades y tratamiento.
Resultados: 75 pacientes pediátricos con vitiligo, de los cuales 65,3% fueron mujeres y 34,7% hombres, con una mediana de edad de 11 años y con edad de inicio de la enfermedad entre 6 y 10 años en el 41,3% de los casos. La forma clínica más frecuente fue el vitíligo no segmentario (78,7%), con la localización más frecuente en cabeza y cuello (57,3%). Se identificó fenómeno de Koebner en el 9,7%, halo nevus en el 5,3% de los pacientes, presencia de estrés emocional previo en el 14,7% y antecedentes familiares de vitíligo en el 9,3%.
Conclusiones: Los hallazgos son similares a los registrados en otros estudios latinoamericanos, destacando que la enfermedad es más común en la población femenina, comienza en la edad escolar y que existe mayor frecuencia de vitíligo no segmentario.
Histiocitosis de células de langerhans una actualización basada en un caso real
Authors: Zavala-Mena Mario , Jimeno-Ortega Isabel , Aedo-Inostroza Gabriel
Published: October 2024

Recién nacido de 39 semanas sexo masculino, con peso adecuado para la edad gestacional, parto vaginal sin complicaciones, madre multípara de 2 de 37 años controles prenatales no revelaron alteraciones.
Se interconsulta dermatología por lesión tumoral congénita en zona plantar de pie izquierdo.
Al examen destaca lesión tumoral de 2 centímetros de diámetro, bien delimitada erosionada con costras en superficie, asociada a lesiones alrededor papulares eritemato-amarillentas y vesiculares de contenido claro
Se realizó escisión completa de la lesión  revelando a la histopatología una Infiltración dermo-epidérmica con células histiocíticas de estirpe linfoide de núcleo ovalado vesiculoso y citoplasma amplio eosinofílico, acompañadas de células gigantes multinucleadas, con inmunohistoquímica positiva para S100, CD1A y Langerina.
Impact of Cost Structure on Indonesia Food Industry Value Added
Authors: Robiani Bernadette , Mukhlis Mukhlis , Hamira Hamira , Apriani Deassy
Published: October 2024

The food industry is a consistently growing sector, even in challenging economic conditions, driven by population growth and increased demand. Recognizing its importance, the Indonesian government has identified the food and beverage industry as a key sector in its Industry 4.0 roadmap. However, challenges such as reliance on imported raw materials and high labor absorption rates persist. This study analyzes the impact of cost structure on the value-added in Indonesia's food industry from 2017 to 2021, using data from Indonesia Statistics on large and medium industries. The Panel Data Regression results reveal that raw material costs and fixed capital costs positively and significantly affect value-added. These findings suggest that effective cost management, innovation, and the use of advanced technology are crucial for optimizing value-added in this sector.
"OMIX" TECHNOLOGIES: BIOCHEMICAL FEATURES OF ACTION NEURO- AND TISSUE-SPECIFIC MARKERS (REVIEW)
Authors: Teplyashina E. , Malinovskaya N. , Shadrina L.
Published: October 2024

The article presents the results of research on modern analytical technologies, which are becoming more important. It is shown that an actively devel-oping approach to early diagnosis of diseases is metabolomics, which studies the biochemical transformations of molecules in the cells of the body. Metabolomic studies based on nuclear magnetic resonance spectroscopy and mass spectrometry open up many opportunities for studying the com-plete metabolomic profile and especially its disorders resulting from adverse environmental factors or gene expression transformation (epigenetics). It is proved that the most common research methods in the framework of modern metabolomics are considered to be metabolic fingerprinting and metabolic profiling. The large possibilities of metabolomic profiling allow us to solve a significant number of fundamental and clinical problems. Fundamental and clinical scientific data have demonstrated the feasibility of a multilateral study of the genesis and course of neurodegenerative disor-ders and cardiovascular diseases at the molecular level. Violation of metabolic pathways in certain organs and tissues can lead to significant changes in the composition of circulating peripheral blood metabolites or brain neurometabolites. Metabolism covers a wide range of biochemical reactions of the body and a diverse set of metabolites, therefore, pathological factors are able to change the metabolic profile of the body at different levels. Analysis of domestic and foreign literature has shown that quantitative determination of lipids in biological samples (lipidomics) is considered equally important in metabolic profiling. This opens up great opportunities for the study of metabolic transformations of lipid molecules, as well as lipid-dependent mechanisms, which is extremely important for the study of neurodegenerative, neurological and neuropsychiatric disorders, since, depend-ing on the associated biochemical pathways of the disease, lipids serve as potential marker molecules of these disorders and can be regarded as necessary diagnostic techniques. The conclusion is formulated about the importance of studying metabolic disorders, a more detailed understanding of the pathogenetic mechanisms of the occurrence of diseases at the molecular level, the search for new marker molecules and additional factors leading to pathological conditions of the body.
ANXIOLYTIC ACTION OF OROSTACHYS SPINOSA DRY EXTRACT
Authors: Razuvaeva Ya. , Bayandueva E. , Toropova A. , Nikolaeva I.
Published: October 2024

The study purpose: to evaluate the anxiolytic effect of the Orostachys spinosa dry extract. Material and methods. The studies were carried out on Wistar rats. An aqueous solution of the O. spinosa extract at doses of 50, 100 and 200 mg/kg was administered to the experimental groups animals for 14 days prior to testing. The anxiolytic effect of the O. spinosa extract was evaluated in the tests: "open field", "elevated plus maze", "light/dark chamber", "unmotivated aggression" and "conflict situation" according to Vogel. Results. It was found that the O. spinosa extract at doses of 100 and 200 mg/kg increases the vertical, horizontal activity and the index of the mink reflex in the "open field"; the entries number and the time into the open arms in the elevated plus maze; the transitions number and the time spent in the light section in the "light/dark chamber". Under conditions of "punishable behavior", the O. spinosa extract at a dose of 100 mg/kg exhibits anti-aggressive and anxiolytic effects. The studied extract reduces the anxiogenic effects of bicuculline and picrotoxin in the Vogel test. Conclusion. The O. spinosa dry extract has an anxiolytic effect, which is due to its stimulating effect on the GABAergic system.
THE EFFECT OF HIGH-TEMPERATURETREATMENT ON THE SORPTION PROPERTIES OF NATURAL BLUE CLAY
Authors: Kormishina A. , Markevich M.
Published: October 2024

Relevance. Natural mineral clays are widely used not only in technology, but also in medicine, cosmetology, and the food industry, due to their unique properties. The high degree of dispersion, sorption-adhesive properties of clay materials, as well as the rich mineral composition also determine their therapeutic effect. Depending on the area and purpose of use, clays are subjected to heat treatment, which can lead to a change in their properties. The purpose of the work is to study the influence of various heat treatment modes on the sorption properties of clay for its further use in pharmaceutical practice. Material and methods. The object of study is Kimmeridgian blue powdery of clay blue Undory in the Ulyanovsk region. Determination of clay moisture content was carried out using an AND MF–5 moisture analyzer (Japan). To completely remove moisture from clay by high-temperature treatment, an SNOL 7.2/1100 electric furnace (Lithuania) was used. The influence of the clay calcination regime on the thermal stability of the clay powder and the ongoing endo- and exothermic effects with loss of sample mass was studied using a Q-1500D derivatograph (Hungary). Adsorption activity was assessed by direct spectrophotometry using an SF-56 “LOMO-Spectrum” spectrophotometer (Russia). Results. DTA of the derivatogram showed the thermal stability of the clay powder in the temperature range from 20°C to 900°C with variations in endo- and exothermic effects. Based on these data, heat treatment modes and sample exposure time were selected. The experiment showed a statistically significant decrease in adsorption activity with increasing temperature and various variations in exposure time. Conclusions. To preserve the adsorption properties of clay blue Undory when removing moisture from it, it is not rational to use high-temperature treatment. The most optimal parameters for drying clay are: temperature 80 ° C, exposure time - 240 minutes.
DEVELOPMENT OF APPROACHES TO THE ANALYSIS OF ELEMENTAL IMPURITIES IN TITANIUM DIOXIDE (ARSENIC DEFINITION)
Authors: Paskar I. , Kapiturova O. , Borkovskaya E. , Troshin V. , Paskar N.
Published: October 2024

I.M. Sechenov First Moscow State Medical University (Sechenov University) Ministry of Health of the Russian Federation (Moscow, Russia) Relevance. Titanium dioxide plays an important role at all stages of the drug’s life cycle: from protecting active ingredients to improving the quality of care for patients when taking the drug. Despite the ongoing debate about its safe use, it remains one of the most sought-after adjuvants in the phar-maceutical industry today. An important factor in the safety of any component of the drug is the control of its content of elemental impurities. Since for titanium dioxide the pharmaceutical requirements for the content of elemental impurities differ significantly, it was advisable to develop approaches to their definition under the most stringent regulations. Research objective. This work is devoted to the development of approaches to the analysis and further validation of the method of determination of arsenic in the substance titanium dioxide at the level of 1 ppm. Material and methods. The basis of the used method was the conditions of the monograph USP «Titanium Dioxide», where a solution of silver di-ethyldithiocarbatum is used as an arsenic reagent. All the reagents and materials used were pharmacopoeic. A sample of titanium dioxide, produced by Venator Germany GmbH, Germany, was used as the research object. The validation of the methodology was carried out in accordance with the re-quirements of the State Pharmacopoeia of the Russian Federation on the following characteristics: specificity, linearity, LOQ, correctness, repeatability, intralaboratory precision and range of the technique. Results. The application of the technique using diethyldithiocarbamate silver as reagent to determine arsenic at 1 ppm is shown. At the same time, the validation evaluation of the methodology showed that the obtained results met the criteria of acceptability for all the studied characteristics. Conclusions. Due to its properties, the substance titanium dioxide remains in demand in the pharmaceutical industry as a adjuvant. In this case, one of the factors of its safe use is the control of its content of elemental impurities. Due to the wide variety of pharmacopoeic requirements for the content of elemental impurities in the substance titanium dioxide. This study demon-strated the applicability of the technique using diethyldithiocarbamate silver as a reagent to determine arsenic at the most stringent of its standards (1 ppm). The validation of the technique proved that it was possible to quantify the arsenic content of titanium dioxide in the range from 50% (LOQ) to 150% of the specification level.
ANTIOXIDANT ACTIVITY OF 2-ARYL-7,7-DIMETHYL-5-OXO-5,6,7,8-TETRAHYDROQUINOLINE-4-CARBOXYLIC ACIDS
Authors: Zykova S. , Namyatova K. , Ovchinnikov D. , Shurov S.
Published: October 2024

Relevance. Oxidative stress is an imbalance between the production of reactive oxygen species and the ability of the endogenous antioxidant sys-tem, and is also part of the pathogenesis of a number of diseases. Recently, antioxidants have been included in the complex treatment of many pathological conditions, so the search for compounds with an antioxidant effect is relevant. Aim. Study of the antioxidant activity of 2-aryl-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydroquinoline-4-carboxylic acids in a model of oxidative stress induced by hydrogen peroxide in a cell culture of E. coli strain "Ecolume." Material and methods. 2-Aryl-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydroquinoline-4-carboxylic acids were obtained as a result of the interaction of 4-aroyl-2,4-dioxobutane acids with 3-amino-5,5-dimethylcyclohex-2-enone. The evaluation of the antioxidant activity of the synthesized compounds was carried out by an indirect method of assessing changes in the fluorescence of E. coli cell culture strain "Ecolume" using a model of oxidative stress in-duced by hydrogen peroxide. Results. Among 2-aryl-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydroquinoline-4-carboxylic acids, compounds with antioxidant activity exceeding the reference standard – trolox were found. Conclusions. Investigation of the antioxidant activity of 9 compounds of the 2-aryl-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydroquinoline-4-carboxylic acid se-ries using E. coli cell culture as a biosensor.
THE STUDY OF THE YELLOW TETRAZOLIUM SALT REDUCTION TO FORMAZAN IN HеLa CELLS
Authors: Semushkina A. , Kabanov D.
Published: October 2024

Relevance. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test is one of the most common used methods for determining cell viability (cytotoxicity) during cell response to plant’s extract or individual extract’s compound. Despite of extensive use of this method it remains unclear whether plasma membrane of cells is destroyed by MTT-formazan crystals during MTT reduction to MTT-formazan; whether the MTT-formazan is lost after cell destruction by MTT-formazan crystals. The purpose of this study was to assess by microscopy and spectrophotometry methods the possibility of MTT-formazan releasing into cultural medium during MTT reduction to MTT-formazan by HeLa cells. Material and methods. HeLa cells were grown on coverslips in Weighing bottles, incubated with MTT (0.1 or 0.5 mg/ml final concentrations) and visualized by light microscopy after 30 min, 60 min, 120 min and 240 min after MTT addition. For spectrophotometry measurements cells (5×104 cells/well) were added to a 96-well plate followed by MTT. The absorbance spectrum was recorded after 30 min, 60 min, 120 min and 240 min after MTT addition. Results. Microscopic examination revealed two phases in MTT reduction by cells to MTT-formazan – the formation of granules and crystals of MTT-formazan. The maximum ratio of crystals to granules of MTT-formazan and almost complete destruction of cells were observed by light microscopy at 240 min of incubation with MTT. However, in the study by spectrophotometry after cell destruction by dimethyl sulfoxide the values of optical density of the MTT-formazan after 120 min as well as 240 min of incubation were almost the same. Therefore, the transformation of MTT-formazan from granules to crystals does not affect the optical density despite of cell destruction. Culture medium without cells did not reduce MTT to MTT-formazan. In the supernatant from cells without their destruction the significant production of MTT-formazan was also not observed. Conclusions. MTT-formazan crystals do not dissolve in the culture medium but dissolve in hydrophobic solvents such as dimethyl sulfoxide. In this regard the destruction of cells by MTT-formazan crystals does not lead to significant loss of MTT-formazan during MTT reduction by HeLa cells and does not significantly effect on results of cytotoxicity determined by MTT test.
DEVELOPMENT OF COMPOSITIONS AND TECHNOLOGY OF GELS CONTAINING PHYTOEXTRACTS
Authors: Kovtun E. , Stepanova E. , Kulshmanova N. , Kulgav Е. , Pleten` A. , Prokopov A. , Tatarenko-Kozmina T.
Published: October 2024

Relevance. Today, interest in the use of natural medicinal substances, medicinal products created on their basis and corresponding dosage forms continues to develop. This interest is associated with the unique properties of various phytocompositions, as well as with the intensive development of such classical sciences as biology, chemistry, and pharmacology. An urgent task is the development and introduction into production of original do-mestic dosage forms for external use, created on the basis of medicinal plant raw materials, which will solve the issues of successful pharmacother-apy for a number of diseases. The purpose of our research is to develop optimal compositions of gels based on Ginkgo biloba leaves and Rhodiola rosea rhizomes with roots of thick extracts, their biopharmaceutical studies in vitro for subsequent more in-depth pharmacotechnological studies. Material and methods. The object of our research is soft dosage forms developed on the basis of thick extracts of Ginkgo biloba leaves and Rho-diola rosea rhizomes with roots. Thick extracts were obtained by condensation in a rotary vacuum evaporator), into which the extracts and an alcohol-water-glycerin mixture 1:6:3 were placed. The ratio of thick extract and solvent mixture was 1:1. Mixing was carried out with a stirrer rotating no more than 30 rpm at room temperature until the mass was completely homogenized. The release of biologically active substances was studied by direct dif-fusion into agar and gelatin gels and by equilibrium dialysis through a semipermeable membrane. Results. Studies have shown that the most complete and rapid release of the active complex of the thick extract of Rhodiola rosea occurs from the Na-CMC base (TU 9199-001-07508109-2004). The highest degree of release of the active complex of the thick extract of Ginkgo biloba is observed from the chitosan base (TU 9289-067-00472124-03 Bioprogress LLC). Conclusions. In vitro biopharmaceutical studies were carried out to determine the level of release of the studied active substances of thick extracts of Rhodiola rosea rhizomes with roots and Ginkgo biloba leaves from various gel compositions, allowing to select the optimal composition of the dos-age form.
Design of Microhydro Power Plant Prototype by Utilizing Irrigation Water in Rice Fields Based on IoT
Authors: Handini Wike , Widanti Nurdina , Lestari Sri Wiji , Haqq Ahmad Raafi , Hafizh Ahmad , Mulyadi Bagus
Published: October 2024

With increasing energy consumption where energy use still comes from fossil energy sources, so that renewable energy development efforts are needed. Utilization of renewable energy with seasonal conditions in Indonesia where rainfall is quite high, besides that there are also many rivers, waterfalls, irrigation water available in Indonesia and almost spread throughout the region. So this condition can be utilized in the water sector where flowing water is used to drive a turbine connected to a DC generator to produce a DC power source. The generating system used is the Micro Hydro Power Plant (MHP) by utilizing irrigation water in rice fields. The methods used in this research are literature study, site observation, system design, testing and data collection. In the data collection and observations made, the river flow is mathematically calculated regarding the water discharge, and also monitors the results using the IoT application.
Model of Tsunami Mitigation and Evacuation Routes in Pancer Banyuwangi
Authors: Trisnawati Trisnawati , Surjono Surjono , Hakiem Luchman
Published: October 2024

Banyuwangi has the largest tsunami disaster risk in East Java, about 45,305 affected people, Rp. 160,886,000,- for the risk of physical losses, Rp. 106,414,000,- for the risk of economic losses and 84 ha of environmental losses (BNPB, 2023). In addition, according to historical data, Banyuwangi was hit by tsunami on June 9, 1994 with magnitude of 7.8 which caused a maximum run up of 14.0 m and killed 238 lives (BNPB, 2023). Also based on Undang- undang No. 24 Tahun 2007 concerning Disaster Management, Indonesia should have preventive and mitigation measures for tsunami disasters both before and after as an effort to reduce the disaster risk (Putra, 2009) . Tsunami modeling in southern Java using COMCOT v1.7 as tsunami worst case scenario in Banyuwangi is the first step for mitigation. The initial results of COMCOT were then used for preparing tsunami disaster evacuation route planning based on the Tsunami Natural Disaster Evacuation Route Planning Guidelines, Dirjen Bina Marga, 2023. The final step is validation/routing survey of the 8 (eight) routes that have been determined. 2 (two) of the 8 (eight) routes fulfill the guidelines for planning tsunami mitigation routes. However, all routes can be considered due to the distribution of settlements, the number of affected residents and the number of routes needed
RANCANG BANGUN APLIKASI SIMULASI TES TOEFL BERBASIS WEBSITE (STUDI KASUS: PROGRAM STUDI TEKNIK INFORMATIKA UNIVERSITAS MATARAM)
Authors: Astuti Yuli Yana , Anjarwani Sri Endang , Irmawati Budi
Published: October 2024

One measure of a person's English proficiency can be seen from the TOEFL test scores obtained. TOEFL (Test of English as a Foreign Language) is a test used to measure a person's English proficiency. If the TOEFL test score has reached a predetermined standard, it can be used for various selection requirements, such as scholarships and college graduation requirements. Based on the regulation of the Chancellor of the University of Mataram Number 7 of 2021 Article 17 Paragraph 8 Letter g, students who wish to conduct a thesis trial need to attach a certificate of completion of the TOEFL test first as proof that the student has indeed taken the TOEFL test and passed the score determined by the program. respective studies or majors, including the Informatics Engineering Study Program. So that in this study the authors will design and build a website based TOEFL test simulation application at the Informatics Engineering Department, University of Mataram. This study uses the CodeIgniter (CI) framework and the personal extreme programming (PXP) system development method. Testing on this application uses the black box testing method and the Mean Opinion Score (MOS). The result is that the application can run properly according to its respective functionality and get a MOS value of 4.6 where this value shows that the TOEFL test simulation application has good quality to use.
RANCANG BANGUN SISTEM INFORMASI “OBATPEDIA” SEBAGAI MEDIA EDUKASI TENTANG OBAT-OBATAN BERBASIS WEBSITE
Authors: Rizki Muhammad Ainur , Murpratiwi Santi Ika , Anjarwani Sri Endang
Published: October 2024

Today, the ease of obtaining medicines for the public has improved significantly thanks to developments in technology and healthcare infrastructure. Access to medicines has become easier through pharmacies. A survey of 35 community members in Lombok, West Nusa Tenggara showed that 85.3% stored medicines without doctor's instructions and needed education on the proper use of medicines. A survey of 23 pharmacists also showed that 95.5% of pharmacists need a drug education platform that makes it easier for them to provide drug education. Departing from the problem of the lack of public understanding of medicines and the need for pharmacists to provide drug education easily, this study aims to design and build an information system, “ObatPedia,” as an educational media about website-based medicines. The method used is Personal Extreme Programming (PXP) because this website will be developed flexibly, quickly, and responsive to change. In this method, some stages are passed, including Planning, Iteration, Initialization, Design, Implementation, and Testing, so the website can be developed with the expected features and usability. The results Mean opinion score of this system a Mean Opinion score of 4.345 from the public and 4.472 from pharmacists on a scale of 1 to 5, which shows that users strongly agree that the ObatPedia website can help to increase public knowledge and understanding of medicines.