bluuebunny/crossref_metadata_2025 huggingface dataset:
Cross-Cultural Adaptation and Validation of the Italian Version of the Dysphagia Handicap Index (I-DHI)
Authors: Ginocchio Daniela , Ninfa Aurora , Pizzorni Nicole , Lunetta Christian , Sansone Valeria Ada , Schindler Antonio
Published: September 2021

The Dysphagia Handicap Index (DHI) is a valid Health-related Quality of Life (HRQOL) questionnaire for patients with oropharyngeal dysphagia (OD) of heterogeneous etiologies. The study aimed at crossculturally translating and adapting the DHI into Italian (I-DHI) and analyzing I-DHI reliability, validity, and interpretability. The I-DHI was developed according to Beaton et al. 5-stage process and completed by 75 adult OD patients and 166 healthy adults. Twenty-six patients filled out the I-DHI twice, 2 weeks apart, for test–retest reliability purposes. Sixty-two patients completed the Italian-Swallowing Quality of Life Questionnaire (I-SWAL-QoL) for criterion validity analysis. Construct validity was tested comparing I-DHI scores among patients with different instrumentally assessed and self-rated OD severity, comparing patients and healthy participants and testing Spearman’s correlations among I-DHI subscales. I-DHI interpretability was assessed and normative data were generated. Participants autonomously completed the I-DHI in maximum 10 min. Reliability proved satisfactory for all I-DHI subscales (internal consistency: α > .76; test–retest reliability: intraclass correlation coefficient > .96, k = .81). Mild to moderate correlations (− .26 ≤ ρ ≤ − .72) were found between I-DHI and I-SWAL-QoL subscales. Construct validity proved satisfactory as (i) moderate to strong correlations (.51 ≤ ρ ≤ .90) were found among I-DHI subscales; (ii) patients with more severe instrumentally or self-assessed OD reported higher I-DHI scores (p < .05); and (iii) OD patients scored higher at I-DHI compared to healthy participants (p < .05). Interpretability analyses revealed a floor effect for the Emotional subscale only and higher I-DHI scores (p < .05) for healthy participants > 65 years. In conclusion, the I-DHI is a reliable and valid HRQOL tool for Italian adults with OD.
Policy invariant explicit shaping: an efficient alternative to reward shaping
Authors: Behboudian Paniz , Satsangi Yash , Taylor Matthew E. , Harutyunyan Anna , Bowling Michael
Published: September 2021

Reinforcement learning(RL) is a powerful learning paradigm in which agents can learn to maximize sparse and delayed reward signals. Although RL has had many impressive successes in complex domains, learning can take hours, days, or even years of training data. A major challenge of contemporary RL research is to discover how to learn with less data. Previous work has shown that domain information can be successfully used to shape the reward; by adding additional reward information, the agent can learn with much less data. Furthermore, if the reward is constructed from a potential function, the optimal policy is guaranteed to be unaltered. While suchpotential-based reward shaping(PBRS) holds promise, it is limited by the need for a well-defined potential function. Ideally, we would like to be able to take arbitrary advice from a human or other agent and improve performance without affecting the optimal policy. The recently introduceddynamic potential-based advice(DPBA) was proposed to tackle this challenge by predicting the potential function values as part of the learning process. However, this article demonstrates theoretically and empirically that, while DPBA can facilitate learning with good advice, it does in fact alter the optimal policy. We further show that when adding the correction term to “fix” DPBA it no longer shows effective shaping with good advice. We then present a simple method calledpolicy invariant explicit shaping(PIES) and show theoretically and empirically that PIES can use arbitrary advice, speed-up learning, and leave the optimal policy unchanged.
Cadmium affects autophagy in the human intestinal cells Caco-2 through ROS-mediated ERK activation
Authors: Mireault Myriam , Xiao Yong , Barbeau Benoît , Jumarie Catherine
Published: September 2021

Cadmium is a toxic metal that enters the food chain. Following oral ingestion, the intestinal epithelium has the capacity to accumulate high levels of this metal. We have previously shown that Cd induces ERK1/2 activation in differentiated but not proliferative human enterocytic-like Caco-2 cells. As autophagy is a dynamic process that plays a critical role in intestinal mucosa, we aimed the present study 1) to investigate the role of p-ERK1/2 in constitutive autophagy in proliferative Caco-2 cells and 2) to investigate whether Cd-induced activation of ERK1/2 modifies autophagic activity in postconfluent Caco-2 cell monolayers. Western blot analyses of ERK1/2 and autophagic markers (LC3, SQSTM1), and cellular staining with acridine orange showed that ERK1/2 and autophagic activities both decreased with time in culture. GFP-LC3 fluorescence was also associated with proliferative cells and the presence of a constitutive ERK1/2-dependent autophagic flux was demonstrated in proliferative but not in postconfluent cells. In the latter condition, serum and glucose deprivation triggered autophagy via a transient phosphorylation of ERK1/2, whereas Cd-modified autophagy via a ROS-dependent sustained activation of ERK1/2. Basal autophagy flux in proliferative cells and Cd-induced increases in autophagic markers in postconfluent cells both involved p-ERK1/2. Whether Cd blocks autophagic flux in older cell cultures remains to be clarified but our data suggest dual effects. Our results prompt further studies investigating the consequences that Cd-induced ERK1/2 activation and the related effect on autophagy may have on the intestinal cells, which may accumulate and trap high levels of Cd under some nutritional conditions.

Graphical abstract
Attention Biases to Threat in Infants and Parents: Links to Parental and Infant Anxiety Dispositions
Authors: Aktar Evin , Nimphy Cosima A. , Kret Mariska E. , Pérez-Edgar Koraly , Raijmakers Maartje E. J. , Bögels Susan M.
Published: September 2021

Parent-to-child transmission of information processing biases to threat is a potential causal mechanism in the family aggregation of anxiety symptoms and traits. This study is the first to investigate the link between infants’ and parents’ attention bias to dynamic threat-relevant (versus happy) emotional expressions. Moreover, the associations between infant attention and anxiety dispositions in infants and parents were explored. Using a cross-sectional design, we tested 211 infants in three age groups: 5-to-7-month-olds (n = 71), 11-to-13-month-olds (n = 73), and 17-to-19-month-olds (n = 67), and 216 parents (153 mothers). Infant and parental dwell times to angry and fearful versus happy facial expressions were measured via eye-tracking. The parents also reported on their anxiety and stress. Ratings of infant temperamental fear and distress were averaged across both parents. Parents and infants tended to show an attention bias for fearful faces with marginally longer dwell times to fearful versus happy faces. Parents dwelled longer on angry versus happy faces, whereas infants showed an avoidant pattern with longer dwell times to happy versus angry expressions. There was a significant positive association between infant and parent attention to emotional expressions. Parental anxiety dispositions were not related to their own or their infant’s attention bias. No significant link emerged between infants’ temperament and attention bias. We conclude that an association between parental and infant attention may already be evident in the early years of life, whereas a link between anxiety dispositions and attention biases may not hold in community samples.
Experimental testing of density- and season-dependent growth in vegetative Fucus aquaculture and modelling of growth over one year for different cultivation scenarios
Authors: Meichssner Rafael , Krost Peter , Schulz Rüdiger
Published: September 2021

In the Kiel Fjord, western Baltic Sea, an experimental culture of Fucus vesiculosus and Fucus serratus has been established in order to develop a sustainable method for biomass production of these species. The cultivation method includes the unattached rearing of fronds in drifting baskets and their vegetative reproduction by cutting of small vegetative apices. In this study, we performed culture experiments to measure growth rates with this method at different initial stocking densities (1–5 kg m−2) and during different seasons of the year. Using the results, we modelled growth over 1 year for different cultivation scenarios (different initial stocking densities (1–4.75 kg m−2) and harvest densities (1.25–5 kg m−2)) in order to identify optimal scenarios and estimate annual yields and the number of necessary harvests in these scenarios. Fucus vesiculosus showed a parabolic yield–density relationship with decreasing yields at high initial stocking densities (> 2.5 kg m−2). In contrast, F. serratus showed an asymptotic yield–density relationship with rather constant yields at high initial stocking densities. Both species showed a typical seasonal growth pattern with low growth rates during winter and high growth rates during summer; however, F. serratus seemed to be growth limited during summer which was not observed for F. vesiculosus. The modelling results reflected the results of the Density experiment: for F. vesiculosus, optimal cultivation scenarios were found for intermediate cultivation densities (initial stocking densities, 1.75–2.25 kg m−2; harvest densities, 3–4 kg m−2); for F. serratus, optimal cultivation scenarios included higher densities (initial stocking densities, 2.5–4 kg m−2; harvest density, 5 kg m−2). The model scenarios predicted maximal annual yields of 6.65–6.76 kg m−2 for F. vesiculosus and 6.88–6.99 kg m−2 for F. serratus. For both species, the number of harvests necessary to achieve these yields varied depending on the cultivation scenario from 2 to 6. Scenarios with only 1 harvest per year yielded slightly lower annual yields. We conclude that the modelling results offer a valid and helpful orientation for future efforts to produce Fucus species in commercial culture.
Psychosocial Working Conditions Play an Important Role in the Return-to-Work Process After Total Knee and Hip Arthroplasty
Authors: Kamp Tamara , Brouwer Sandra , Hylkema Tjerk H. , van Beveren Jan , Rijk Paul C. , Brouwer Reinoud W. , Stevens Martin
Published: September 2021

Purpose Both personal and work-related factors affect return to work (RTW) after total knee arthroplasty (TKA) and total hip arthroplasty (THA). Little is known about work-related factors associated with the recovery process. This study aimed to determine which work-related factors are associated with time to RTW for both TKA and THA patients. Methods A prospective multicenter survey study was conducted that included patients aged 18–63, had a paid job and were scheduled to undergo primary TKA/THA. Surveys were completed preoperatively, 6 weeks, and 3, 6, and 12 months postoperatively, and included four domains of work-related factors: work characteristics, physical working conditions, psychosocial working conditions and work adjustments. Control variables included age, sex, education, and comorbidity. Time to RTW was defined as days from surgery until RTW. Multivariate linear regression analyses were conducted separately for TKA/THA patients. Results Enrolled were 246 patients (n = 146 TKA, n = 100 THA, median age 56 years, 57% female). Median time to RTW was 79 days (IQR 52.0–146.0). Mainly physical tasks (TKA: B 58.2, 95%CI 9.5–106.8; THA: B 52.1, 95%CI 14.1–90.2) and a combination of physical and mental tasks (TKA: B 50.2, 95%CI 6.4–94.0; THA B 54.0, 95%CI 24.2–83.7) were associated with longer time to RTW after both TKA and THA. More possibilities for personal job development (B − 12.8, 95%CI − 25.3–0.4) and more work recognition (B − 13.2, 95%CI − 25.5 to − 0.9) were significantly associated with shorter time to RTW after TKA. Higher quality of supervisor leadership (B − 14.1, 95%CI − 22.2 to − 6.0) was significantly associated with shorter time to RTW after THA. Conclusion The findings of this study stress the importance of psychosocial working conditions, besides type of job tasks, in RTW after TKA/THA. Further research on work-related factors is needed, as arthroplasty is being performed on an increasingly younger population of knee and hip OA patients for whom participating in work is of critical importance.
Adolescent Victim Types Across the Popularity Status Hierarchy: Differences in Internalizing Symptoms
Authors: Malamut Sarah T. , Dawes Molly , van den Berg Yvonne , Lansu Tessa A. M. , Schwartz David , Cillessen Antonius H. N.
Published: September 2021

Previous studies have called attention to the fact that popular youth are not immune to peer victimization, suggesting there is heterogeneity in the popularity of victims. Yet, no study to date has determined whether victims with different levels of popularity status can be identified using person-oriented analysis. Such analysis is critically needed to confirm the existence of popular victims. Further, there remains a paucity of research on internalizing indices of such popular victims, especially compared to other victim and non-victim groups. To address this gap in the research literature, the current study used latent profile analysis to identify subgroups of victims based on victimization (self- and peer-report) and popularity (peer-report). This study sought to verify the existence of popular victims and to compare victim subgroups on loneliness and self-esteem. Participants were 804 Dutch adolescents (50.2% boys, Mage = 13.65 years, ranging from 11.29 to 16.75 years). The results revealed six subgroups, including a group of popular self-identified victims. Popular self-identified victims were generally less lonely than other victims, but had higher loneliness and lower self-esteem than non-victims. Implications are discussed for understanding the victimization experiences of high-status youth.
Paradoxes of truth-in-context-X
Authors: Gauker Christopher
Published: September 2021

We may suppose that the truth predicate that we utilize in our semantic metalanguage is a two-place predicate relating sentences to contexts, thetruth-in-context-Xpredicate. Seeming paradoxes pertaining to the truth-in-context-X predicate can be blocked by placing restrictions on the structure of contexts. While contexts must specify a domain of contexts, and what a context constant denotes relative to a context must be a context in the context domain of that context, no context may belong to its own context domain. A generalization of that restriction appears to block all of the paradoxes of truth-in-context-X. This restriction entails that, in a certain sense, we cannot talk about the context we are in. This result will be defended, up to a point, on broadly ontological grounds. It will also be conjectured that our semantic metalanguage can be regarded as semantically closed.
A unique venue of discoveries in structural chemistry and structural biology: the 75-year and 60-year jubilees of the MRC Laboratory of Molecular Biology—a personal tribute
Authors: Hargittai Istvan , Hargittai Magdolna
Published: September 2021

In 1962, the MRC Laboratory of Molecular Biology in Cambridge, UK, moved into a new building and continued a success story that had begun 15 before. Milestone discoveries and Nobel Prizes have followed ever since. They have led to profound changes in our basic ideas about the nature of life and the way medicine operates. Structural chemistry has paved the way for this unprecedented progress.
Seismic velocity modeling in the digital transformation era: a review of the role of machine learning
Authors: AlAli Abdullah , Anifowose Fatai
Published: September 2021

Seismic velocity modeling is a crucial step in seismic processing that enables the use of velocity information from both seismic and wells to map the depth and thickness of subsurface layers interpreted from seismic images. The velocity can be obtained in the form of normal moveout (NMO) velocity or by an inversion (optimization) process such as in full-waveform inversion (FWI). These methods have several limitations. These limitations include enormous time consumption in the case of NMO due to manual and heavy human involvement in the picking. As an optimization problem, it incurs high cost and suffers from nonlinearity issues. Researchers have proposed various machine learning (ML) techniques including unsupervised, supervised, and semi-supervised learning methods to model the velocity more efficiently. The focus of the studies is mostly to automate the NMO velocity picking, improve the convergence in FWI, and apply FWI using ML directly from the data. In the purview of the digital transformation roadmap of the petroleum industry, this paper presents a chronologic review of these studies, appraises the progress made so far, and concludes with a set of recommendations to overcome the prevailing challenges through the implementation of more advanced ML methodologies. We hope that this work will benefit experts, young professionals, and ML enthusiasts to help push forward their research efforts to achieving complete automation of the NMO velocity and further enhancing the performance of ML applications used in the FWI framework.
Role of Predictive Mortality Calculator in Antenatal Assessment of Congenital Diaphragmatic Hernia
Authors: Ishak Azril , Abu Hassan Hasyma , Mohd Jamil Amilia Afzan , Ramesh Vairavan
Published: September 2021

Congenital diaphragmatic hernia (CDH) is one of the most common major congenital anomalies. In utero visceral organ herniation into the thoracic cavity can result in lung hypoplasia and pulmonary hypertension may ensue. Post-natal mortality rates in isolated CDH remain high reaching up to 80% in severe cases. Several prenatal predictors of morbidity and mortality have been proposed. Reliable predictive markers can aid clinicians in providing effective family counselling, prediction of survival, and propose therapeutic options. Decreased total fetal lung volume (TFLV) via magnetic resonance imaging (MRI) has been reported to be significantly associated with mortality. We report on 2 cases of CDH, with fetal MRI performed at third trimester, focusing on the TFLV and observed-to-expected TFLV. We would like to highlight the importance of predictive mortality calculator which provides statistical data for healthcare providers in counselling families and aids in risk-stratification.
Recurrent Fetal Hydrops: Importance of Genetic Testing with Exome Sequencing—A Case Report
Authors: Raman Srimathy , Prakash Prakruthi K. , Shirodkar Savitha , Gururaj Shreelakshmi , Venkataram Padmalatha
Published: September 2021

We report the case of a pregnant lady who had hydrops fetalis in three successive pregnancies and discuss the possible genetic causes and the systematic approach to evaluation of her pregnancy and her future reproductive options. Hydrops fetalis can occur due to a heterogeneous number of causes. Systematic evaluation helps in determining the cause which then determines the prognosis as well as recurrence in future pregnancies. Recurrent hydrops though rare, can occur because of single gene defects causing hematological, neurological, cardiac conditions, etc. Genetic testing and consideration of the role of exome sequencing is important in counseling families regarding their future pregnancy options as well as to offer prenatal diagnosis.
Effects of Three Genres of Focus Music on Heart Rate Variability and Sustained Attention
Authors: Kirk Ulrich , Ngnoumen Christelle , Clausel Alicia , Purvis Clare Kennedy
Published: September 2021

Previous research has demonstrated restorative effects of music, showing that exposure to music yields mental health benefits that include improvement in stress management. However, it remains unclear whether the benefits of “on the spot” music interventions extend to cognitive performance. The present study explored whether music can be applied as a low-cost, non-invasive “on the spot” intervention to improve cognitive performance and physiological effects. Specifically, studies has yet to examine whether the effects of different genres of focus music extend beyond stress management to include cognitive performance and physiological effects. To address this gap in the literature, the current study recruited 120 healthy adults in a fully randomized procedure involving three experimental groups of participants and a control group. Each experimental group was exposed to one specific genre of focus music compared to a no-music control group. In a between-group design, the study exposed three separate groups to jazz music, piano music, and lo-fi music respectively. The fourth group was a no-music control group. The study employed a 3-day experimental procedure and a follow-up procedure in which participants completed two attention monitoring tasks. Participants completed focus music interventions with a duration of 15 and 45 min. The follow-up procedure aimed to experimentally induce music familiarity and probe its effect on cognitive performance. To assess cardiovascular effects, heart rate variability (HRV) data was collected during the music intervention period and during a baseline period. Results showed performance differences across the three active music groups on the sustained attention to response task (SART) compared to the no-music control group. Furthermore, the study showed a physiological effect in the direction of increased parasympathetic activity indexed as an increased HRV response in the three active music groups compared to the no-music control group, adding to convergent lines of evidence suggesting that music can enhance parasympathetic activity and cognitive performance. In addition, the study found that music familiarity (relative to music unfamiliarity) influenced cognitive performance in the direction of faster reaction times (RTs) during the music intervention period in which participants were exposed to the attentional network task (ANT) and an increase in the physiological response in the familiar relative to the unfamiliar music condition. In summary, the study found evidence of a pronounced effect of three types of focus music on both cognitive performance and the underlying physiological response. Thus, focus music holds promise as an evidence-based intervention offering mental health benefits through physiological improvements and enhancement of cognitive processing.
A Generalized Approach to Longitudinal Momentum Determination in Cylindrical Straw Tube Detectors
Authors: Ikegami Andersson Walter , Akram Adeel , Johansson Tord , Kliemt Ralf , Papenbrock Michael , Regina Jenny , Schönning Karin , Stockmanns Tobias
Published: September 2021

The upcoming PANDA experiment at FAIR will be among a new generation of particle physics experiments to employ a novel event filtering system realised purely in software, i.e. a software trigger. To educate its triggering decisions, online reconstruction algorithms need to offer outstanding performance in terms of efficiency and track quality. We present a method to reconstruct longitudinal track parameters in PANDA’s Straw Tube Tracker, which is general enough to be easily added to other track finding algorithms that focus on transversal reconstruction. For the pattern recognition part of this method, three approaches are employed and compared: a combinatorial path finding approach, a Hough transformation, and a recursive annealing fit. In a systematic comparison, the recursive annealing fit was found to outperform the other approaches in every category of quality parameters and reaches a reconstruction efficacy of 95% and higher. Due to its computational simplicity, the recursive annealing fit was also found to have faster execution times compared to the other algorithms.
Online exams and the COVID-19 pandemic: a hybrid modified FMEA, QFD, and k-means approach to enhance fairness
Authors: Gorgani Hamid Haghshenas , Shabani Sharif
Published: September 2021

COVID-19 pandemic caused an increasing demand for online academic classes, which led to the demand for effective online exams with regards to limitations on time and resources. Consequently, holding online exams with sufficient reliability and effectiveness became one of the most critical and challenging subjects in higher education. Therefore, it is essential to have a preventive algorithm to allocate time and financial resources effectively. In the present study, a fair test with sufficient validity is first defined, and then by analogy with an engineering product, the design process is implemented on it. For this purpose, a hybrid method based on FMEA, which is a preventive method to identify potential failure modes and prioritize their risk, is employed. The method's output is provided to the QFD algorithm as the needs of product customers. Then, the proposed solutions to prevent failures are weighted and prioritized as the product's technical features. Some modifications are made to the classic form of FMEA in the proposed method to eliminate its deficiencies and contradictions. Therefore, our proposed algorithm is a precautionary approach that works to prevent breakdowns instead of fixing them following their occurrence. This issue is very effective in increasing the efficiency of activities in times of crisis. Eventually, a prioritized list of preventive actions is provided, allowing us to choose from available solutions in the circumstances with limited time and budgetary, where we cannot take all possible actions.
Three-dimensional strain analysis of asphalt pavement based on vehicle–pavement model of interaction
Authors: Zhang Runfeng , Liu Xiaolan , Zhang Xianmin
Published: September 2021

This study analyzes the 3D (3D) strain on a pavement by using a model of a vehicle with seven degrees of freedom and that of a road in elastic half-space by using the finite element software ANSYS. The results are as follows: The 3D strain on the two wheels along the centerline was significantly influenced by the superposition of the wheel, and the 3D strain under a single wheel was far higher than that along the centerline of two wheels, and represented the most unfavorable position on the road. The vertical strain consisted mainly of compressive strain at different depths, and that at the bottom of the pavement was slightly higher than that on top. The longitudinal and transverse strains were all compressive strains on top of the pavement and tensile strains at the bottom, respectively. The longitudinal and transverse strains both on top and at the bottom of the pavement were similar. The authors then analyzed the influence of the thickness of the pavement, its modulus, and equivalent resilient modulus on the vertical compressive strain, longitudinal tensile strain, and transverse tensile strain in case of a single wheel. Furthermore, a model to predict the 3D strain under the comprehensive effect of the structural parameters of the road was established. It can provide the basis and a reference for the design, construction, fault detection, and maintenance of roads.
In vitro antiplasmodial activity, cytotoxicity, antioxidant action and GC-FID analysis of Allanblackia floribunda Oliv
Authors: Irabor Francis , Ebohon Osamudiamen , Erhunse Nekpen , Okugbo Osariemen T. , Omoregie Ehimwenma S.
Published: September 2021

This study evaluated the in vitro antiplasmodial efficacy and cytotoxicity of Allanbackia floribunda stem bark extract, leaf extract and oil. It also assessed the phytochemical compositions and antioxidant action of the stem bark fractions as well as the phytochemical fingerprint of the most active fraction (dichloromethane). Trager and Jensen method was used to culture Plasmodium falciparum, Mark III test developed by WHO was used to assess the antiplasmodial activity of the plant’s crude extract and fractions against the ring stage of P. falciparum strain, Pf3D7. Cytotoxicity was determined against Vero cell line using microculture tetrazolium (MTT) test. Gas chromatography with flame ionization detection (GC-FID) was employed to identify phytochemical fingerprint of the most active fraction. The stem bark extract had better antiplasmodial activity (IC50Pf3D7 of 4.3 ± 0.17 μg/mL) compared with the leaf extract (IC50Pf3D7, 8.0 ± 0.28 μg/mL) and oil (IC50Pf3D7 > 100 μg/mL). Both the leaf and stem bark extracts were found to be non-cytotoxic compared with the standard cytotoxic drug, doxorubicin. The selectivity indices (S.I.) of the extracts against the parasite were 20.06 and 8.85 for the stem bark and leaf respectively. Dichloromethane fraction had the highest inhibition against the P. falciparum parasite with IC50Pf3D7 of 1.51 μg/ mL. GC-FID analysis showed high presence antiplasmodial flavonoids and terpenes. This investigation confirmed that A. floribunda stem bark has potent activity against P. falciparum, and it is relatively safe to normal cell.

Article Highlights

Allanblackia floribunda methanol stem bark and leaf extracts could inhibit the growth of chloroquine sensitive Plasmodium falciparum (Pf3D7) in vitro.

The stem bark infusion of Allanblackia floribunda was found to be nontoxic and safe at moderate doses to normal cell line (Vero cell line).

Dichloromethane fraction of the stem bark showed excellent inhibition against chloroquine sensitive malaria parasite.
Exploring How and Why to Develop Patient-Centered Packaging: A Multiple-Case Study with Pharmaceutical Companies
Authors: Carli Lorenzini Giana , Olsson Annika
Published: September 2021

Background

Patient centricity has gained attention ranging from regulatory authorities to patient advocacy groups, calling for pharmaceutical companies to revise their traditional business approach to drug development by including the development of solutions that are meaningful in patients’ lives. Medication packaging is one area where empirical evidence is lacking about the incorporation of patient centricity. This study aimed to explore patient centricity applied to pharmaceutical companies’ packaging, and to identify the specific challenges faced and lessons learned when developing patient-centered packaging.

Methods

The study followed a multiple-case study research approach based on five cases of patient-centered packaging development in mid- and large-sized pharmaceutical companies.

Results

Patient-centered packaging is often associated with the intuitive and self-explanatory use of the medication by patients. Patient-centered packaging comes with challenges, but also offers opportunities for the creation of better solutions for patients and learning for the teams involved. To overcome these challenges, it is essential to build a business case that justifies such development, one where patient needs are present from the start and aligned with other imperative deadlines of drug development, with stakeholders onboard.

Conclusion

Patient-centered packaging is the exception rather than the norm in packaging development due to a conventional approach where packaging plays an ancillary role to drug protection. The cases presented here challenge this approach and can inspire other companies to carry out patient-centered packaging development. The cases are also relevant to other actors who are interested in continuously promoting the dialogue about patient centricity in healthcare.
Spaces of Measures and their Applications to Structured Population Models
Authors: Düll Christian , Gwiazda Piotr , Marciniak-Czochra Anna , Skrzeczkowski Jakub
Published: September 2021

Structured population models are transport-type equations often applied to describe evolution of heterogeneous populations of biological cells, animals or humans, including phenomena such as crowd dynamics or pedestrian flows. This book introduces the mathematical underpinnings of these applications, providing a comprehensive analytical framework for structured population models in spaces of Radon measures. The unified approach allows for the study of transport processes on structures that are not vector spaces (such as traffic flow on graphs) and enables the analysis of the numerical algorithms used in applications. Presenting a coherent account of over a decade of research in the area, the text includes appendices outlining the necessary background material and discusses current trends in the theory, enabling graduate students to jump quickly into research.
Paths to Kingship in Medieval Latin Europe, c. 950–1200
Authors: Weiler Björn
Published: September 2021

Medieval Europe was a world of kings, but what did this mean to those who did not themselves wear a crown? How could they prevent corrupt and evil men from seizing the throne? How could they ensure that rulers would not turn into tyrants? Drawing on a rich array of remarkable sources, this engaging study explores how the fears and hopes of a ruler's subjects shaped both the idea and the practice of power. It traces the inherent uncertainty of royal rule from the creation of kingship and the recurring crises of royal successions, through the education of heirs and the intrigue of medieval elections, to the splendour of a king's coronation, and the pivotal early years of his reign. Monks, crusaders, knights, kings (and those who wanted to be kings) are among a rich cast of characters who sought to make sense of and benefit from an institution that was an object of both desire and fear.
Global Corpse Politics
Authors: Auchter Jessica
Published: September 2021

Taboos have long been considered key examples of norms in global politics, with important strategic effects. Auchter focuses on how obscenity functions as a regulatory norm by focusing on dead body images. Obscenity matters precisely because it is applied inconsistently across multiple cases. Examining empirical cases including ISIS beheadings, the death of Muammar Qaddafi, Syrian torture victims, and the fake death images of Osama bin Laden, this book offers a rich theoretical explanation of the process by which the taboo surrounding dead body images is transgressed and upheld, through mechanisms including trigger warnings and media framings. This corpse politics sheds light on political communities and the structures in place that preserve them, including the taboos that regulate purported obscene images. Auchter questions the notion that the key debate at play in visual politics related to the dead body image is whether to display or not to display, and instead narrates various degrees of visibility, invisibility, and hyper-visibility.
The Cambridge History of Atheism
Authors: Ruse Michael
Published: September 2021

The two-volume Cambridge History of Atheism offers an authoritative and up to date account of a subject of contemporary interest. Comprised of sixty essays by an international team of scholars, this History is comprehensive in scope. The essays are written from a variety of disciplinary perspectives, including religious studies, philosophy, sociology, and classics. Offering a global overview of the subject, from antiquity to the present, the volumes examine the phenomenon of unbelief in the context of Christian, Islamic, Buddhist, Hindu, and Jewish societies. They explore atheism and the early modern Scientific Revolution, as well as the development of Charles Darwin's theory of evolution and its continuing implications. The History also includes general survey essays on the impact of scepticism, agnosticism and atheism, as well as contemporary assessments of thinking. Providing essential information on the nature and history of atheism, The Cambridge History of Atheism will be indispensable for both scholarship and teaching, at all levels.
The Economics and Regulation of Network Industries
Authors: Vogelsang Ingo
Published: September 2021

Have you ever wondered how your telephone company or Internet service provider can give you access to almost all people in the world, or how electricity suppliers can compete with each other if there is only one electric supply line passing through your street? This Element deals with the economics and public regulation of such network industries. It puts particular emphasis on the specific economic concepts used for analyzing them and on the regulatory reform movement and the compatibility of regulation and competition. Worldwide most of these industries have changed dramatically in recent years, telecommunications in particular. Network industries mostly exhibit economies of scale in production and similar economies in consumption. Both of these properties cause market power problems that often require industry-specific regulation. However, due to technological and market changes network policies have moved on from end-user regulation to wholesale regulation and in some cases to deregulation.
The Information Revolution in Early Modern Europe
Authors: Dover Paul M.
Published: September 2021

This provocative new history of early modern Europe argues that changes in the generation, preservation and circulation of information, chiefly on newly available and affordable paper, constituted an 'information revolution'. In commerce, finance, statecraft, scholarly life, science, and communication, early modern Europeans were compelled to place a new premium on information management. These developments had a profound and transformative impact on European life. The huge expansion in paper records and the accompanying efforts to store, share, organize and taxonomize them are intertwined with many of the essential developments in the early modern period, including the rise of the state, the Print Revolution, the Scientific Revolution, and the Republic of Letters. Engaging with historical questions across many fields of human activity, Paul M. Dover interprets the historical significance of this 'information revolution' for the present day, and suggests thought-provoking parallels with the informational challenges of the digital age.
Cyberbullying and internet safety: a survey of child and adolescent mental health practitioners
Authors: Lonergan Aoife , Moriarty Amy , McNicholas Fiona , Byrne Triona
Published: September 2021

Objectives:

Cyberbullying is increasingly recognised as a threat for young people’s mental health. Young people and their families may not know how to stay safe online or how to respond following unsafe internet experiences. This study aimed to examine Child and Adolescent Mental Health Service (CAMHS) staff perceived knowledge, practice and attitudes towards cyberbullying (CB) and internet safety (IS), and their training needs.

Methods:

A descriptive, survey design was used. 59 CAMHS clinicians completed a study specific online survey examining their knowledge, practice, attitudes and training needs regarding CB and IS. Frequency and descriptive statistics were conducted on participant responses.

Results:

Clinicians reported that risky internet behaviour and CB were frequent experiences reported by youth attending their clinical practice. Professionals were aware of potential adverse effects on the young person, including social withdrawal, low self-esteem, anxiety, self-injurious behaviour and suicidal thoughts. Training for young people on online behaviour and good digital citizenship skills was a highly endorsed preference. The majority of respondents felt CAMHS staff have a role in supporting families and managing IS and identified training and resource materials as strategies to assist them in this regard.

Conclusions:

Findings support a need for clinicians to regularly inquire about internet use, safety and adverse online experiences. The ongoing development of resources and training in CB and IS for CAMHS clinicians, children and caregivers is necessary. Further research is warranted due to the small sample size and the subjective nature of the current study.
Evolution of wake structures behind oscillating hydrofoils with combined heaving and pitching motion
Authors: Verma Suyash , Hemmati Arman
Published: September 2021

The wake of an oscillating teardrop hydrofoil with combined heaving and pitching motion was studied numerically at Reynolds number of 8000 and Strouhal numbers of

$St=0.21{-}0.94$

. The lower Strouhal number exhibited high efficiency propulsion with small thrust generation. However, larger thrust generation at high

$St$

required more power, which lowered the propulsive efficiency. Quantitative assessment of vortex evolution, along with qualitative investigation of the formation and interaction of primary structures, revealed the association with elliptic instability characteristics for both co-rotating and counter-rotating vortex structures in both wakes. With respect to advection of the leading-edge vortex, the pressure distribution further depicted evidence of spanwise instability with distinct temporal evolution along the suction and pressure surfaces of the oscillating foil. Three-dimensional assessment of wake structures located downstream of the trailing edge depicted the existence of dislocations associated with primary vortex ‘rollers’. At low

$St$

, these were limited to fine spanwise corrugations (valleys and bulges) on weaker leading edge rollers, which enlarged as the rollers advected downstream. In contrast, at high

$St$

, the wake exhibited conjoint hairpin-horseshoe vortex structures that led to stronger deformations on the coupled vortex rollers. The statistical characteristics of secondary structures resembled the long wavelength mode and mode A identified previously for purely pitching and heaving foils, respectively. They also mimicked mode B for stationary cylinders. Novel wake models are introduced based on a complete vivid three-dimensional depiction of coherent wake structures.
Structured input–output analysis of transitional wall-bounded flows
Authors: Liu Chang , Gayme Dennice F.
Published: September 2021

Input–output analysis of transitional channel flows has proven to be a valuable analytical tool for identifying important flow structures and energetic motions. The traditional approach abstracts the nonlinear terms as forcing that is unstructured, in the sense that this forcing is not directly tied to the underlying nonlinearity in the dynamics. This paper instead employs a structured-singular-value-based approach that preserves certain input–output properties of the nonlinear forcing function in an effort to recover the larger range of key flow features identified through nonlinear analysis, experiments and direct numerical simulation (DNS) of transitional channel flows. Application of this method to transitional plane Couette and plane Poiseuille flows leads to not only the identification of the streamwise coherent structures predicted through traditional input–output approaches, but also the characterization of the oblique flow structures as those requiring the least energy to induce transition, in agreement with DNS studies, and nonlinear optimal perturbation analysis. The proposed approach also captures the recently observed oblique turbulent bands that have been linked to transition in experiments and DNS with very large channel size. The ability to identify the larger amplification of the streamwise varying structures predicted from DNS and nonlinear analysis in both flow regimes suggests that the structured approach allows one to maintain the nonlinear effects associated with weakening of the lift-up mechanism, which is known to dominate the linear operator. Capturing this key nonlinear effect enables the prediction of a wider range of known transitional flow structures within the analytical input–output modelling paradigm.
Kurdistan on the Sèvres Centenary: How a Distinct People Became the World’s Largest Stateless Nation
Authors: Radpey Loqman
Published: September 2021

In August 1920, the political fate of the Kurdish nation, along with its territory, Kurdistan, were on the line, after the Allies asserted their interest in national rights to self-determination following World War I. Under the Treaty of Sèvres, Kurds were acknowledged as an ethno-political entity in the Wilsonian perspective, yet the ideal of self-determination failed to crystallize as a full legal right to independent nationhood. Thus, Kurdish statehood was annulled. In contrast, the drawing of states’ boundaries in Europe took place mostly along national lines. The result has been an untenable diversity across regions affected by the War in the varieties of self-determination, arguing that some peoples’ nationhood was credited with less legitimacy than others. The departure of imperial powers and subsequently the League of Nations from self-determination for achieving territorial independence came as a result of imperialist world policies to reorder political influence. With the adoption of self-determination as one of the purposes of the UN in 1945, and with the crystallization of self-determination as a legal right in 1966 and the subsequent campaign of decolonization, it could be argued the Kurds’ status was not repositioned and in some way is invisible to the law of self-determination, as applied.
Global Capital Cycles and Market Discipline: Perceptions of Developing-Country Borrowers
Authors: Zeitz Alexandra O.
Published: September 2021

Developing countries are often thought to be particularly exposed to the constraints of global markets. Facing scrutiny from foreign investors, why do developing-country governments enter international bond markets, especially when they can access cheaper finance from international financial institutions? I argue that borrowing governments' perception of market constraints depends on global liquidity. When bond markets are highly liquid, investors become more risk acceptant and governments perceive the political costs of borrowing to be lower, especially compared to the conditionality of concessional loans. I use data on the timing of bond issues and three case studies—Ethiopia, Ghana, and Kenya—to demonstrate that choices to issue debt were shaped by global liquidity. These findings nuance debates about how markets constrain governments, emphasizing that market constraints are conditional on systemic factors, including, global liquidity.
Complications of combination intranasal corticosteroids and anti-retroviral therapy
Authors: James J , Caulley L , Collins J , Hopkins C
Published: September 2021

Background

Intranasal corticosteroids are widely used for management of many upper airway diseases because of their ability to effectively deliver local relief of inflammation.

Case report

This paper presents the case of a 51-year-old man with human immunodeficiency virus treated with ritonavir who was started on fluticasone intranasal spray for presumed chronic rhinosinusitis. Months after starting this therapy, he developed symptoms of Cushing's syndrome and avascular necrosis of the shoulder due to the pharmacological interactions between fluticasone and ritonavir.

Conclusion

Although intranasal corticosteroids are deemed a low-risk route of drug administration, clinicians need to be vigilant in appropriately prescribing corticosteroids in the setting of drug potentiators, particularly in these high-risk patients. Alternative corticosteroids such as beclomethasone dipropionate should be considered in such cases.
Analysis of the isotropic and anisotropic Grad–Shafranov equation
Authors: Jeyakumar S. , Pfefferlé D. , Hole M.J. , Qu Z.S.
Published: September 2021

Pressure anisotropy is a commonly observed phenomenon in tokamak plasmas, due to external heating methods such as neutral beam injection and ion-cyclotron resonance heating. Equilibrium models for tokamaks are constructed by solving the Grad–Shafranov equation; such models, however, do not account for pressure anisotropy since ideal magnetohydrodynamics assumes a scalar pressure. A modified Grad–Shafranov equation can be derived to include anisotropic pressure and toroidal flow by including drift-kinetic effects from the guiding-centre model of particle motion. In this work, we have studied the mathematical well-posedness of these two problems by showing the existence and uniqueness of solutions to the Grad–Shafranov equation both in the standard isotropic case and when including pressure anisotropy and toroidal flow. A new fixed-point approach is used to show the existence of solutions in the Sobolev space

$H_0^1$

to the Grad–Shafranov equation, and sufficient criteria for their uniqueness are derived. The conditions required for the existence of solutions to the modified Grad–Shafranov equation are also constructed.