bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of Long Term Cyclamate and Saccharin Consumption on Biochemical Parameters in Healthy Individuals and Type 2 Diabetes Mellitus Patients
Authors: Hasan Husni Muhammed , Alkass Suad Yousif , de Oliveira Daniele Suzete Persike
Published: November 2022

Previous studies on saccharin and cyclamate were either limited to experimental animals or lacking evaluation of their long-term consumption effects in humans. This study evaluated the effect of chronic consumption of saccharin and cyclamate on biochemical parameters in healthy individuals and patients with type 2 diabetes mellitus. Healthy and diabetic individuals were classified into two groups based on whether they consumed sweeteners or not. The participants were classified according to the amount of sweetener consumed per day and duration of consumption. Serum catalase activity, peroxynitrite, ceruloplasmin and malondialdehyde concentrations were determined. Glycated hemoglobin, fasting glucose, creatinine, alanine transaminase and lipid profile were also evaluated. Saccharin and cyclamate increased HbA1C (+ 11.16%), MDA (+ 52.38%), TG (+ 16.74%), LDL (+ 13.39%) and TC/HDL (+ 13.11%) in healthy volunteers. Diabetic patients consuming sweetener showed increased FSG (+ 17.51%), ceruloplasmin (+ 13.17%) and MDA (+ 8.92%). Diabetic patients showed positive correlation between the number of tablets consumed per day with FSG and serum creatinine. Positive correlation was found between the duration of sweetener consumption and FSG as well as TG. consumption of saccharin and cyclamate affected biochemical parameters related to metabolic functions in a time and dose dependent manner and appear to increase oxidative stress in healthy and diabetic type 2 patients.
‘Our Bodies are Not Strong Anymore’: A Focus Group Study of Health Risk Perception of Ambient Air Pollution Near a Petrochemical Industry.
Authors: Okoye Ogochukwu , Carnegie Elaine , Luca Mora
Published: November 2022

Background
Ambient air pollution has persisted in many communities resulting in chronic human exposure to unhealthy pollutants. Epidemiological studies on air pollution have been mainly quantitative with a dearth of information on health risk perception, a key component of environmental health risk management. The aim of this qualitative study was to illuminate the health risk perception of ambient air pollution amongst persons residing near a petrochemical industry. In addition, determine their perception of existing control measures and ideas for more effective control.
Methods
A focus group study of residents near a petrochemical refinery. Participants were purposively selected based on age, sex, long-term residence in the community, occupation, and involvement with community leadership. Three 90mins face-to-face focus groups and one individual interview were conducted while observing COVID-19 safety precautions. The moderator guided discussions using a pre-formed topic guide. All discussions were audio-recorded, transcribed manually and coded using NVivo soft-ware. Data analysis was conducted using reflective thematic analysis proposed by Braun and Clarke.
Results
Twenty-four adults agreed to participate; 23 in three focus groups and one individual interview. Six themes were inductively generated from the data as follows: Negative perception of the environment, the refinery is to blame, Air pollution is seen or smelt, Air pollution is associated with health and non-health risks, Poor response to air pollution: everyone is to blame, and Government is primarily responsible for healthy air quality. The participants perceived their ambient air was polluted mainly by activities of petrochemical industries, but were not aware of the extent of its potential health implications. Key suggestions for air pollution control included stopping gas flaring, regulating tanker drivers and illegal artisanal refineries, environmental health education, dissemination of research findings to stakeholders, access to affordable health care and providing incentives for community members
Conclusions Participants perceive their ambient air was unhealthy, however concern about the health risks was shaped by demographic, socio-economic and other contextual factors. Existing mitigating efforts were perceived as inadequate and the key barriers were poor environmental health literacy and political factors. More inclusive and collaborative approaches are required for improved environmental and public health.
Helium administration is more effective during piston-driven high-frequency oscillatory ventilation than conventional mechanical ventilation in a rabbit model
Authors: Akiyama Louis , Tatsunami Shinobu , Akita Mieko , Shimizu Naoki
Published: November 2022

Background
Low-molecular-weight gases such as helium are more likely to form laminar flows. Using helium-oxygen mixtures instead of nitrogen-oxygen mixtures during mechanical ventilation has been shown to accelerate carbon dioxide (CO2) excretion. Helium-oxygen mixtures have been used with mechanical ventilator settings such as high-frequency oscillatory ventilation (HFOV) and conventional mechanical ventilation (CMV). However, to the best of our knowledge, studies have not been conducted to determine the optimal ventilator setting for the promotion of CO2 excretion when helium is administered. This study aimed to compare the efficacy of using helium-oxygen gas mixtures between pressure-controlled CMV and piston-driven HFOV in rabbit models. CO2 transition was evaluated using blood gas analysis performed during and after helium administration. Experimental data were analyzed using parametric statistical methods. A repeated measures analysis of variance was used to compare CO2 excretion between HFOV and CMV.
Results
There was no statistically significant difference in the partial pressure of CO2 (PaCO2) or oxygen (PaO2) values before or after helium administration. Compared with pre-helium administration, PaCO2 values during helium administration were decreased under both CMV and piston-driven HFOV. Moreover, the PaCO2 transition during helium administration while using piston-driven HFOV was shown to be statistically significantly different (P < 0.001).
Conclusions
This study demonstrated that helium enhances CO2 elimination more significantly during piston-driven HFOV compared with that in CMV in rabbit models with normal lungs. With further study and clinical trials, these results imply that the use of HFOV while using a helium-oxygen mixture may improve CO2 excretion.
Untangling the inhibitory effect of dust aerosols on weak precipitation
Authors: Wang Jinyan , Xie Xiangshan , Ding Ruiqiang , Yasheng Dilinuer , Wang Tianyu , Sun Caixia , wang Zhiyi
Published: November 2022

As one of the most abundant and widely distributed aerosols in the troposphere, dust aerosols act as condensation nucleus to alter the life cycle of clouds and precipitation, thus affecting weather and climate. However, the effects of dust aerosols on precipitation are still not fully understood, particularly for the raindrop size distribution (DSD) of weak precipitation and thus warrant investigations. Taking multiple precipitation episodes occurring from March 15th to April 1st, 2021 in Pudong, Shanghai, China as an example, we attempt to reveal the underlying impacts of dust aerosols on weak precipitation’s DSD. Compared with the weak precipitation events with and without dust aerosols, we find that dust aerosols may inhibit weak precipitation. In details, the mean mass weighted average diameter (Dm) of dust-carrying precipitation is much smaller than the weak precipitation without dust aerosols, while the mean value of normalized intercept parameters (Log10Nw) of dust carrying precipitation is greater than the dust-free precipitation. Moreover, the dust-carrying precipitation episodes have higher (lower) number concentration of small (large) raindrops than the precipitation events without dust aerosols, demonstrating that dust aerosols could lead to a significant increase (decrease) in the number concentration of small (large) raindrops. As a results, dust aerosols are favorable to stimulate a more concentrated distribution of raindrop size and a smaller spectral width, prolonging the life of clouds and thus inhibiting weak precipitation. These findings highlight the inhibitory effect of dust aerosols on weak precipitation and can provide scientific insights for weather and climate prediction.
DSS For Personal Financial Planning
Authors: Kannammal A , Harini C , Roshini G
Published: November 2022

Personal financial planning is an essential tool for people over various age groups that assists people in planning their financial needs for now and later as years move on. The planning includes segregation of money into various activities that might include daily expenses, emergency expenses and savings. For an employee who plans to save for the future it becomes necessary to plan his daily expenditure, and select an appropriate investment strategy which will in turn decrease financial risk in later ages of retirement. Financial management professionals help in managing funds into controlled transactions which will later provide the investor a greater financial support and return over years. It is not always efficient and reliable to find professionals who provide financial solutions with sound knowledge on returns through the investment analyzing the risk involved, to make financial planning a more reliable and easy approach, using softwares are the better ways. Through a software or analytical based approach it is always possible to ensure that there are sufficient funds available for individuals at any stage of life. Financial management tools help individuals cultivate a habit of budgeting their expenses and avoid unnecessary spending, also, they tend to prioritize tier spending patterns. This also helps to identify the full cashflow for both monthly and yearly expenses and saving then this plan recommends some investment plan from the range of risk-taking score for each individual.
Bifurcation analysis for a diffusive predator-prey system with spatial heterogeneity and delays
Authors: Zhang Hua , Wei Junjie
Published: November 2022

In this paper, we consider a diffusive Lotka-Volterra predator-prey system with spatial heterogeneity and two delays. We first show that there exists a nonconstant positive steady state when the diffusion rates of prey and predator are large. Then we obtain the stability of the steady state and show the existence of a Hopf bifurcation. Moreover, some numerical simulations are provided to illustrate our theoretical results.
MSC 2010: 35K57, 37G15, 37N25, 92D25
Single-cell RNA sequencing and molecular docking reveal sinomenine can treat postherpetic neuralgia by regulating the expression of MMP2
Authors: Zhang Hongli , Zhao Yong
Published: November 2022

Objective: The pathogenesis of postherpetic neuralgia is not clear, the pain is severe, the duration is long, and the treatment effect is poor. We explored the potential mechanism of sinomenine in the treatment of postherpetic neuralgia based on single-cell sequencing and molecular docking technology and provided a theoretical basis for studying the pathogenesis of postherpetic neuralgia.
Methods: Based on single-cell sequencing analysis and bioinformatics, the possible pain-causing factors of postherpetic neuralgia were identified, and the interaction between sinomenine and the target protein was analyzed using the molecular docking technique. First, the genes related to sinomenine and postherpetic neuralgia were found through various databases. Then, single-cell gene sequencing was used to identify pain-related marker genes and their role in cell subsets. The intersection of the differentially expressed (|LogFC|>1) marker gene and the postherpetic neuralgia-related genes in single-cell sequencing was used as the postherpetic neuralgia pain-causing gene set. Intersection of sinomenine and hub genes was used to identify the target genes that interact with each other, and sinomenine was molecularly docked with the target genes.
Results: A total of 2524 postherpetic neuralgia-related genes and 43 sinomenine-related genes were identified through Genecard, CTD, and the GEO database. Single-cell gene sequencing was performed and revealed a total of 680 marker genes between pain and pain-free cell populations |logFC|>1. Pain-associated subpopulations were annotated mainly with microglia and astrocytes. And there were 125 intersection genes associated with postherpetic neuralgia. These genes were associated with the development of postherpetic neuralgia. 42 hub gene were identified from these crossover genes. MMP2 is the common gene of hub genes and sinomenine-related genes. Molecular docking discovers better affinity and stability between sinomenine and MMP2 protein.
Conclusion: This study combined single cell analysis, bioinformatics and molecular docking to identify MMP2 as a potential target for sinomenine in the treatment of postherpetic neuralgia, which may act on microglia to alleviate pain by regulating the neuroinflammatory response and ion pathways.
Clinical outcomes of sodium bicarbonate therapy in critically ill pediatric patients with metabolic acidosis are associated with chloride
Authors: Liu Huaqing , Cao Yanmei , Xue Xiaoyan , Hong Yi , Lu Meihua , Bai Zhenjiang , Wu Shuiyan
Published: November 2022

Background: Metabolic acidosis is a common acid-base imbalance in critically ill patients. Whether sodium bicarbonate (SB) can improve clinical outcomes in the treatment of metabolic acidosis is still controversial. The aim of this study was to determine the factors influencing the clinical efficacy of SB in the treatment of metabolic acidosis and the potential benefit to patients.
Methods: Patients with metabolic acidosis who were treated with or without SB were identified and grouped from a retrospective cohort (Pediatric Intensive Care Unit [PICU] database), from which the clinical data were extracted. The in-hospital mortality curves of the acid-base balance parameters of patients in the two groups were drawn and fitted using the locally-weighted scatter plot smoothing (LOWESS) method. The prevalence ratios (PRs) of in-hospital mortality were estimated by log-binomial regression based on the maximum likelihood method, and the potential confounders, such as age and disease category, were adjusted.
Results: A total of 6,167 children with metabolic acidosis were enrolled, of whom 2,626 (42.58%) were treated with SB. The overall analysis showed that there was no significant difference in the in-hospital mortality rates (9.71% vs. 10.56%, p = 0.275) between children in the SB treatment and non-treatment groups, adjusted PR = 0.929 (95% CI, 0.802-1.072). There was no significant difference in the in-hospital mortality rates as a function of pH and HCO3- between the two groups. The in-hospital mortality rate as a function of chloride was significantly different; specifically, the curve of the untreated group was U-shaped and the curve of the treated group was L-shaped. The curves of the two groups crossed at 110 mmol/L of chloride after LOWESS fitting. There was no statistically significant difference in the risk of death between the SB treatment and non-treatment groups at a chloride < 107 mmol/L and a chloride >113 mmol/L. In the chloride < 107 mmol/L subgroup, SB treatment had a 41.7% increased risk of in-hospital death (adjusted PR=1.417, 95% CI, 1.069−1.481) and a 35.9% increased risk of 28-day death (adjusted PR=1.359, 95% CI, 1.315−1.474). In the chloride≥113 mmol/L subgroup, SB treatment had a 61.1% reduced risk of in-hospital death (adjusted PR=0.389, 95% CI, 0.268−0.553) and a 56.4% reduced risk of 28-day death (adjusted PR=0.436, 95% CI, 0.295−0.631). The median length of stay in the PICU of children in the SB group was also shorter than children in the non-treatment group when the chloride concentration was ≥110 mmol/L.
Conclusions: The clinical outcomes of SB in the treatment of metabolic acidosis are associated with chloride. When the chloride concentration was high (> 110 mmol/L), children benefited from SB treatment and when the chloride concentration was low (< 107 mmol/L), the risk of death increased.
Criticality in transient behavior of coupled oscillator system towards Chimera and Synchronization
Authors: Yao Nan , Zhang Qianyun , Ren Deyi , Li You-Jun , Su Chun-Wang , Huang Zi-Gang
Published: November 2022

Chimera states in spatiotemporal dynamical systems have been investigated in physical, chemical, and biological systems. While how the system is steering towards different final destinies upon spatially localized perturbation is still unknown. Through systematic numerical analysis of the evolution of the spatiotemporal pattern of the multi-cluster chimera states, we uncover a critical behavior of the system in transient time towards either chimera or synchronization as the final stable state. Based on adequate verification, we fit and analyze the distribution of the transient time, and observe power-law variation process as perturbation strengths approaches the critical point, which divided the phase of stable chimera and synchronization states. Moreover, the comparison between different clusters systems shows that the critical points of odd and even clusters converge in proportional like sequences as the cluster number approaches infinity, implying that this critical behavior can be modeled and enabling the articulation of a phenomenological model. Our work explores the criticality in transient behavior as well as the phase transition from chimera to synchronization under increasing perturbation, which may shed new insights to controlling coupled oscillator system with the help of perturbation through inducing phase transition between symmetry and asymmetry self-organized states.
Poor Self-Care Practices and Associated Factors among Type 2 Adult Diabetic Patients on Follow-Up Care at Public Health Facilities of Adama Town, Oromia, Ethiopia
Authors: Deybasso Haji Aman , Bekele Nardos Tilahun , Habtewold Ephrem Menikullih
Published: November 2022

Background Self-care practice plays a significant role in the reduction of life-threatening conditions. The study assessed the magnitude of poor self-care practices and associated factors among type 2 adult diabetic patients in Adama town in Ethiopia. Methods Institution-based cross-sectional study was conducted among 404 patients. Self-care practice was assessed by the summary of diabetes self-care activities questionnaires. Binary logistic regression was used to identify factors associated with poor self-care practices. Adjusted odds ratio with a 95% confidence interval was used to assess the strength of associations. The statistical significance was declared for a p-value < 0.05. Results The magnitude of poor self-care practices was 54% [95%CI: 49.1, 58.6]. Being divorced (AOR = 3.5; 95% CI: 1.0, 12.2), lower level of knowledge (AOR = 1.70; 95% CI: 1.0, 2.8), being on insulin (AOR = 6.3; 95% CI: 1.9, 20.6), taking oral medication (AOR = 8.6; 95% CI: 3.0, 24.5), unaware of fasting blood sugar (AOR = 2.9; 95% CI: 1.6, 5.2), not a member of diabetic association (AOR = 3.6; 95%CI: 1.7, 7.5), lack frequent social support (AOR = 2.9; 95% CI: 1.7, 4.9), and poor perceived benefit of self-care practices (AOR = 1.84; 95% CI: 1.0, 3.2) were associated with poor self-care practices. Conclusion The magnitude of poor self-care practices was higher than the national finding. Marital status, knowledge of diabetes and the level of fasting blood sugar, social support, types of medications, perceived benefit of self-care practices, and membership in the diabetic associations were independent determinants of poor self-care practices.
The role of LOXL2 induced by glucose metabolism-activated NF-κB in maintaining drug resistance through EMT and cancer stemness in gemcitabine-resistant pancreatic cancer
Authors: Lee Yun Sun , Kim Hyung Sun , Kim Hyo Jung , Kang Hyeon Woong , Lee Da Eun , Kim Myeong Jin , Hong Woosol Chris , Kim Ju Hyun , Kim Minsoo , Park Joon Seong
Published: November 2022

Purpose
Gemcitabine is considered a standard treatment for pancreatic cancer, but developing drug resistance greatly limits the effectiveness of chemotherapy and increases the rate of recurrence. Lysyl oxide-like 2 (LOXL2) is highly expressed in pancreatic cancer and is involved in carcinogenesis and EMT regulation. However, studies on the role of LOXL2 in drug resistance are limited. Here, we investigated the mechanism of LOXL2 induction and the effect of LOXL2 on EMT and CSC in gemcitabine-resistant pancreatic cancer.
Methods
Tissue samples from 20 patients with pancreatic ductal adenocarcinoma (PDAC) who received adjuvant gemcitabine-based chemotherapy at Gangnam Severance Hospital. Expression of EMT and stemness markers was analyzed by western blot, qPCR, and flow cytometry, and stem cell capacity was compared using a 3D culture system and spheroid formation assay. Tumor growth and response to gemcitabine in vivo were also determined in mouse models.
Results
Activated NF-κB directly induces transcription by binding to the promoters of LOXL2 and ZEB1. The EMT process was significantly inhibited by the coregulation of ZEB1 and LOXL2. In addition, LOXL2 inhibition reduced the expression of cancer stemness markers and stemness by regulating MAPK signaling activity. LOXL2 inhibits tumor growth of gemcitabine-resistant pancreatic cancer cells and increases the sensitivity to gemcitabine in mouse models.
Conclusion
We identified a specific mechanism for inducing LOXL2 overexpression in gemcitabine-resistant pancreatic cancer. Taken together, our results suggest LOXL2 has an important regulatory role in maintaining gemcitabine resistance and may be an effective therapeutic target to treat pancreatic cancer.
Morphology, mechanical performance and flame resistance of acrylonitrile butadiene styrene (ABS)/polyphenylene oxide (PPO) blends incorporated with halloysite nanoclay and polyphenylene ether-grafted maleic anhydride
Authors: Tuan Vu Manh , Dat Nguyen Huu , Huynh Mai Duc , Trung Tran Huu , Cong Do Van , Thai Nguyen Thi , Long Pham The , Hai Luong Nhu , Giang Nguyen Vu
Published: November 2022

In this work, the incorporation of halloysite nanotubes (HNTs) and polyphenylene ether-grafted maleic anhydride copolymer (FB) into acrylonitrile butadiene styrene (ABS)/polyphenylene oxide (PPO) blend has been investigated with the aim of enhancing the compatibility and performance of the blends. ABS/PPO blend (AP) with the weight ratio of ABS/PPO = 70/30 with 5 wt.% loading of FB and different weight contents of HNTs were elaborated by melt blending process, and their properties were studied. The SEM observation revealed that AP blend exhibited dispersed phases of PPO droplets with clear gaps between PPO and ABS phases, indicating poor adhesion between the polymers in the blend. As the compatibilizer, FB effectively enhanced the inter-phase interaction, minimizing the formation of interfacial gaps, which was evidenced by the SEM images, leading to the adhesion between ABS, PPO and HNTs phases. As the result, the mechanical performance of the AP blend were significantly improved with the addition of FB and HNTs. At 5 wt.% of HNT, the AP/FB/HNT blend exhibited tensile strength of 37.47 MPa and flexural strength of 59.09 MPa compared to 26.60 MPa and 39.45 MPa of neat AP, respectively. The glass transition points of the modified blends showed shifts compared to the neat AP, which indicating the improvement in miscibility of the modified-AP blends. The thermal stability and flame resistance of the blends were also enhanced with the introduction of HNTs and FB, evidenced with the V-1 rating in the UL-94 test as well as the increase in limiting oxygen index (LOI). These results demonstrated that the incorporation of HNTs and FB is a promising and simple method to improve the properties of ABS/PPO blends.
The psoas muscle density as a predictor of postoperative complications in elderly patients undergoing rectal cancer resection
Authors: Xiao Yunzhou , Wen Xiaoting , Ying Yingying , Zhang Xiaoyan , Li Luyao , Wang Zhongchu , Su Miaoguang , Zheng Xiangwu , Miao Shouliang
Published: November 2022

ObjectiveMuscle depletion that impairs normal physiological function in elderly patients leads to poor prognosis. This study aimed to evaluate the association between total abdominal muscle area (TAMA), total psoas area (TPA), psoas muscle density (PMD), and short-term postoperative complications in elderly patients with rectal cancer.
MethodsAll elderly patients underwent rectal cancer resection with perioperative abdominal computed tomography (CT). Complications were assessed according to the Clavien-Dindo classification. Severe complications were defined as grade III-V following the Clavien-Dindo classification. Univariate and multivariate analyses were performed to evaluate risk factors of short-term severe postoperative complications.
ResultsThe cohort consisted of 191 patients with a mean age of 73.60±8.81 years. Among them, 138 (72.25%) patients had Clavien-Dindo 0- II, 53 (27.75%) patients had severe postoperative complications (Clavien-Dindo III-V), and 1(0.52%) patient died within 30 days of surgery. PMD was significantly higher in the Clavien-Dindo 0-II cohort compared to the Clavien-Dindo III-V cohort (p=0.004). Nevertheless, TAMA and TPA failed to exhibit significant differences. Moreover, the multivariate regression analysis implied that advanced age [OR 1.07 95%CI (1.02–1.13) p=0.013], male [OR 5.03 95%CI (1.76-14.41) p=0.003], high CCI score [OR 3.60 95%CI (1.44-9.00) p=0.006], and low PMD [OR 0.94 95%CI (0.88-0.99) p=0.04] were independent risk factors of Clavien-Dindo III-V.
ConclusionPreoperative assessment of the PMD on CT can be a simple and practical method for identifying elderly patients with rectal cancer at risk for severe postoperative complications.
Granulomatous Prostatitis after Bacille Calmette-Guérin Instillation Resembles Prostate Carcinoma: A Case Report
Authors: Yao Yu , Ji Jun-Jie , Wang Hai-Yun , Sun Li-Jiang , Zhang Gui-Ming
Published: November 2022

Background: Bacille Calmette-Guérin (BCG) instillation is recommended in patients with non-muscle-invasive bladder cancer who have intermediate-risk and high-risk tumors. However, granulomatous prostatitis is a rare complication induced by BCG instillation, which can easily be misdiagnosed as prostate cancer. Here, we report a case of granulomatous prostatitis that resembled prostate cancer.
Case presentation: A 64-year-old Chinese man who was diagnosed with non-muscle-invasive bladder cancer received BCG instillation. Three days later, he was diagnosed with urinary tract infection. He stopped BCG instillation and received anti-infective therapy. BCG instillation was restarted 14 months later. Three months after BCG restart, he presented with rising levels of total prostate-specific antigen (PSA) (9.14 ng/mL) and a decreasing ratio of free PSA/total PSA (0.09). Digital rectal examination revealed a moderately enlarged, non-painful prostate gland with normal density. In multiparametric prostate magnetic resonance imaging (MRI), axial T2-weighted images showed a 28 mm × 20 mm diffuse abnormality with a low signal in the right peripheral zone. On diffusion-weighted MRI with a high b-value, the lesion was seen as a markedly hyperintense focus, which was consistent with a lesion with a Prostate Imaging Reporting and Data System score of 5, with a hypointense signal on an apparent diffusion coefficient map image. Considering the possibility of prostate cancer, a prostate biopsy was conducted. Histopathology showed benign prostate tissue with typical features of granulomatous prostatitis. The nucleic acid test for tuberculosis was performed and the result was positive. The patient was finally diagnosed with BCG-induced granulomatous prostatitis. Thereafter, he stopped BCG instillation again and received anti-tuberculosis treatment. During a follow-up visit after 10 months, the patient presented with no evidence of tumor recurrence or symptoms of tuberculosis.
Conclusion: Although histopathology is the only way to accurately differentiate between BCG-induced granulomatous prostatitis and prostate cancer, some clues such as temporarily elevated PSA levels and a high signal followed by a low-signal abnormality on high b-value diffusion-weighted MRI are important indicators of BCG-induced granulomatous prostatitis.
How the Quantity and Hue Contrast of Interface Color Coding Affect Human Perception: Evidence from Two EEG Studies
Authors: Ma Changyun , Wang Haiyan , Wu Jinchun , Xue Chengqi
Published: November 2022

Background Color has considerable effects on physiological and psychological perception in human-machine interaction, but it is unclear how the coding methods of interface color affect users’ perception. The present study investigated the impacts of two dimensions of color coding, quantity and hue contrast, on visual perception from three aspects: brain activity, emotional experience, and visual comfort.
Methods Based on the HSV color space, two sets of experiments were designed with three quantity levels of colors and four quantity levels of hues (8, 16, 36 X 1, 2, 4, Random) as well as five combinations of two hue contrasts (30º, 60º, 120º, 180º, 240º in the HSV hue wheel). Participants’ brain activities were monitored within 2000ms of viewing the color stimuli, and subjective evaluations of their emotional and visual experiences were collected. Significant differences were observed in the synchronization of delta (0-4 Hz) and theta (4–8 Hz) bands in the 0-500ms time window and gamma (30-100Hz) oscillation throughout the presentation by using event-related spectral perturbations (ERSPs).
Results Expanded color elicited significantly higher arousal of emotion, along with stronger delta and theta band synchronization in the parietal and occipital lobes and enhanced gamma power in the posterior cortex, indicating increased visual processing workload and attention input. Grouping on identical hue significantly weakened the activation of delta and theta bands and did not enhance gamma oscillation as shape Gestalt as the number of groups rose, suggesting that color grouping capably lessens the perceptual load of visual processing. In addition, sharper hue contrasts significantly boosted delta and theta band activity and enhanced low gamma (30-50Hz) activation, and undermined visual experience compared with softer combinations, which might relate to the concentric antagonistic receptive fields of visual cells.
Conclusion This paper gives the first elucidation of the eﬀects of color coding on neural activity and subjective perceptions, contributing to the neuroergonomic study of interface color design. These findings bridge the gap between the neural activity of color vision and mental experience during color perception.
Vitamin D Receptor Gene Polymorphism and Serum Vitamin D Levels with the Risk of Colorectal Cancer: An Observational Case-Control Study
Authors: Yassıbaş Emine , Önen Hacer İlke , Kerem Mustafa , Toka Onur , Samur Gülhan
Published: November 2022

Purpose: Colorectal cancer (CRC) is the third leading cause of cancer death in the world, and its incidence is steadily rising. Understanding the role of modifiable risk factors in colorectal carcinogenesis is one of the primary prevention strategies. This research was conducted to evaluate the relationship between serum vitamin D levels, vitamin D receptor (VDR) gene polymorphisms, and CRC risk.
Methods: Fifty-one CRC patients who were diagnosed within the last three months prior to the study and 51 individuals adjusted by age and sex with the study group were included as controls. Serum vitamin D levels and four different VDR gene polymorphisms (ApaI, BsmI, FokI, and TaqI) were analyzed. Logistic regression analysis was made for the serum vitamin D levels and VDR gene polymorphisms.
Results: It was determined that serum vitamin D deficiency (≤20 ng/mL) increases the CRC risk approximately 5.5 times (OR: 5.452, 95%CI: 1.909-15.568). Also, BsmI, ApaI, TaqI and FokI polymorphisms were not significantly associated with CRC risk (p>0.05). Serum 25(OH)D levels were evaluated according to VDR polymorphism genotypes, it was found that CRC patients with heterozygous (Bb and Aa) genotypes of BsmI and ApaI polymorphisms had significantly lower serum 25(OH)D levels than controls with the same genotype (p<0.05). The distribution of haplotypes did not differ statistically between the groups (p>0.05).
Conclusions: Developing strategies to achieve normal serum vitamin D levels are important to decrease CRC prevalence. To better understanding these associations, further studies with larger sample sizes and other vitamin D pathway genes are needed.
Carbon footprint assessment of a wood multi-residential building considering biogenic carbon
Authors: Ouellet-Plamondon Claudiane , Ramseier Livia , Balouktsi Maria , Delem Laetitia , Foliente Greg , Francart Nicolas , Garcia Antonio , Hoxha Endrit , Lützkendorf Thomas , Rasmussen Freja Nygaard , Peuportier Bruno , Butler Jared , Birgisdottir Harpa , Dowdell David , Dixit Manish , Gomes Vanessa , Silva Maristela Gomes da , Gómez Juan Carlos , Wiik Marianne Kjendseth , Llatas Carmen , Mateus Ricardo , Pulgrossi Lizzie M. , Röck Martin , Saade Marcella Ruschi Mendes , Passer Alexander , Satola Daniel , Seo Seongwon , Verdaguer Bernardette Soust , Veselka Jakub , Volf Martin , Zhang Xiaojin , Frischknecht Rolf
Published: November 2022

Wood and other bio-based building materials are often perceived as a good choice from a climate mitigation perspective. This article compares the life cycle assessment of the same multi-residential building from the perspective of 16 countries participating in the international project Annex 72 of the International Energy Agency to determine the effects of different datasets and methods of accounting for biogenic carbon in wood construction. Three assessment methods are herein considered: two recognized in the standards (the so-called 0/0 method and –1/+1 method) and a variation of the latter (–1/+1* method) used in Australia, Canada, France, and New Zealand. The 0/0 method considers neither fixation in the production stage nor releases of biogenic carbon at the end of a wood product’s life. In contrast, the –1/+1 method accounts for the fixation of biogenic carbon in the production stage and its release in the end-of-life stage, irrespective of the disposal scenario (recycling, incineration orlandfill). The -1/+1 method assumes that landfills offer only a temporary sequestration of carbon. In the –1/+1* variation, landfills and recycling are considered a partly permanent sequestration of biogenic carbon and thus fewer emissions are accounted for in the end-of-life stage. We examine the variability of the calculated life cycle-based greenhouse gas emissions calculated for a case study building by each participating country, within the same assessment method and across the methods. The results vary substantially. The main reasons for deviations are whether or not landfills and recycling are considered a partly permanent sequestration of biogenic carbon and a mismatch in the biogenic carbon balance. Our findings support the need for further research and to develop practical guidelines to harmonize life cycle assessment methods of buildings with bio-based materials.
Effects of Adriamycin-Cytoxan Chemotherapy on Hematological and Electrolyte Parameters among Breast Cancer Patients
Authors: Abiye Fikremariam , Leminie Abebaye Aragaw
Published: November 2022

Background Adriamycin-Cytoxan (AC) is a common chemotherapy treatment for breast cancer (BC) patients. Its electrolyte and hematological adverse effects have not been addressed adequately. Objective This study aimed to assess the effect of AC on hematological and electrolyte parameters among BC patients. Methods A hospital-based comparative cross-sectional study design was conducted from March to November 2022. Randomly selected AC-treated (n = 100) and untreated (n = 100) patients were included. Structured questionnaire and medical records were used to collect sociodemographic data. Anthropometric parameters, hematological indices, and serum electrolytes were measured. Cobas Integra 400+and SYSMEX-XT-4000i were used to analyze serum electrolytes and hematological indices respectively. The data were analyzed using SPSS version 25. Independent t-test and chi-square test were used. P-value \(<\)0.05 was considered statistically significant. Results AC-treated patients’ mean TWBC, NE, LY, RBC, Hgb, HCT, and Na+values were significantly reduced (p < 0.05) than patients with no treatment. However, mean EO, PLT counts, RDW, K+, and PCT values were significantly increased (p < 0.05). Moreover, the mean EO count was significantly increased (p < 0.05) for AC-treated advanced cancer-stage patients. Conclusion The majority of blood cells and serum sodium were affected by AC treatment. Incorporating these parameters in the routine analysis and further studies on the detailed mechanism of action of this drug is required.
Perfil Epidemiológico da Violência contra a Mulher em um Município da Região Sul do Brasil
Authors: Amaral Marcelo Augusto , Dultra Jean Carlos Ramos , Mackincs Gustavo Pereira , Amaral Vitória
Published: November 2022

Introdução: A violência contra a mulher é um problema de saúde pública que traz consequências para a saúde das vítimas e familiares envolvidos, além de suscitar sentimentos como o medo, a angústia, a baixa autoestima, a autodepreciação, o distanciamento social e a dificuldade nas relações interpessoais. Objetivo: Descrever as agressões físicas sofridas por mulheres de um município da região Sul do Brasil, e avaliar os fatores sociodemográficos envolvidos no processo da violência. Material e Métodos: Trata-se de um estudo descritivo analítico transversal, realizado em 319 laudos de mulheres de 18-50 anos atendidas pela Delegacia da Mulher de Maringá/PR, no período compreendido entre janeiro de 2015 a dezembro de 2019. Resultados: Identificou-se que as mulheres com idade média de 32,2±8,7 anos, brancas (86,84%), solteiras (52,35%) e com ocupação profissional do lar (7,52%) foram as principais vítimas da violência do estudo. As lesões mais frequentes foram equimose (43,14%), escoriação (26,67%), hematomas (11,24%) e abuso sexual (3,92%), acometendo principalmente os membros superiores (35,65%), inferiores (20,18%), região maxilofacial (19,27%) e cabeça (8,26%). As lesões em região maxilofacial, de cabeça e pescoço, totalizaram 27,53% da violência sofrida pelas vítimas submetidas aos exames de corpo de delito. A idade das mulheres esteve associada à violência doméstica e/ou de gênero e a elevada prevalência de casos foi observada no ano de 2019 (p<0,05). Conclusão: As mulheres na faixa etária próxima aos 32 anos, de pele branca, solteiras e cuidadoras do lar representam um perfil de risco para a violência doméstica e/ou de gênero. Os traumatismos maxilofaciais são frequentes e evidenciam a importante relação entre a Odontologia e a violência contra as mulheres, bem como revelam sua relevância sobre a qualidade de vida desta população.
Fibroma Odontogênico Periférico Exuberante com Cemento-Ossificação em Paciente Indígena: Relato de Caso
Authors: Souza Karolina Vidinha Figueiredo de , Cabral Lioney Nobre , Pinheiro Tiago Novaes , Oliveira Vivian Bentes de
Published: November 2022

Introdução: na classificação da OMS de 2017, o fibroma cemento-ossificante se enquadra no grupo de tumores odontogênicos benignos mesenquimais/ectomesenquimais, sendo definido como uma neoplasia rara de tecido conjuntivo fibroso maduro, clinicamente se apresenta como lesão exofítica bem delimitada na gengiva, de superfície lisa, formando nódulos macios ou sólidos, com base séssil ou pediculada de coloração rósea, consistência chegando por vezes à dureza óssea. Objetivo: mostrar caso clínico de paciente gênero feminino de 32 anos, apresentando massa nodular, pediculada, com coloração normocrômica em região vestibular e lingual de rebordo mandibular esquerdo, tamanho de 5cm, com consistência firme à palpação. Material e método: por exames de imagem de tomografia computadorizada foi observada lesão hipodensa nodular, expansiva e corticalizada, em vertente esquerda do corpo mandibular. Para elucidação diagnóstica, foi realizada bópsia excisional, sendo a peça foi submetida à análise histopatológica. Resultado: feita a interrelação das características clínicas, imageológicas e exame histopatológico, obteve-se diagnóstico de fibroma odontogênico cemento-ossificante periférico. Conclusão: o controle dos prováveis fatores causais auxilia na prevenção, para pacientes já acometidos e tratados, faz-se necessário o acompanhamento e orientações pós-operatória para evitar recidiva.
Reabilitação com Prótese Obturadora Maxilar após Exérese de Carcinoma Sinosal INI1-(SMARCB1)-Deficiente
Authors: Herszon Maitê Rabelo , Roldâo Thaíssa Freitas , Braga Francisco Pantoja , Nichthauser Brigitte , Leal Cristiane Maria Brasil
Published: November 2022

Ressecções cirúrgicas para tratamento de carcinomas sinosais provocam alterações severas na aparência, interferindo na autoestima dos pacientes e induzindo-os ao isolamento social. A reabilitação com próteses bucomaxilofaciais é a modalidade de tratamento preferível em casos de tumores com altas taxas de recidiva em que a correção cirúrgica é contraindicada, pois melhora a estética e atenua as dificuldades de mastigação, deglutição e fonação. Este artigo objetiva relatar um caso de reabilitação utilizando prótese obturadora maxilar em paciente submetido à maxilectomia parcial que originou comunicação bucosinusal. Paciente do gênero masculino, 32 anos, procurou atendimento odontológico após exérese de um carcinoma sinosal raro. Após anamnese, exames intra e extraoral e análise radiográficas, foi planejada a confecção de prótese parcial removível superior com obturador palatino. Após moldagem da arcada superior, foi obtido o modelo de estudo que foi levado ao delineador, e foi planejada a armação metálica da prótese parcial removível. Foram executados os nichos e desgastes compensatórios e em seguida a moldagem de trabalho, originando o modelo de trabalho sobre o qual foi confeccionada a armação metálica. Após prova da armação metálica e registro oclusal, os modelos foram montados no articulador semiajustável, os dentes foram selecionados e montados. Na prova estética e funcional dos dentes foi constatado o restabelecimento estético e fonético do paciente. Em seguida, foram realizadas moldagem com boca fechada, acrilização, instalação e proservações da prótese. Conclui-se que a prótese obturadora palatina veda a comunicação bucosinusal e promove melhorias na estética, fonética e mastigação, restabelecendo autoconfiança e ressocialização do paciente.
Prevalence of Caries in Schoolchildren in the Rural Area of a Small Municipality in the South of Minas Gerais, Brazil
Authors: Freitas Érica Michelle Gonçalves de Lima , Maciel Ivana Maria Esteves , Schiavianato Larissa Maçais Carvalho , Oliveira Gleisson Miranda de , Gasque Kellen Cristina da Silva , Caldeira Amanda Valentim , Lima Daniela Coêlho de , Pereira Alessandro Aparecido
Published: November 2022

Introduction: Despite advances in caries treatment, the disease still afflicts populations deprived of access to goods and services. Objective: To determine the prevalence of dental caries as well as the dental treatment needs for children aged five to twelve years old from rural public schools in Alfenas/MG. Material and method: Cross-sectional descriptive observational study, carried out through an epidemiological survey, in which data were collected through clinical examination of 364 children from five rural schools in the city. These tests were performed by a calibrated examiner (intra-observer kappa = 0.93), within the institutions, after signing the Free and Informed Consent Form by the person in charge. The prevalence of caries and the need for dental evaluation were observed, using the DMFT and DMFT-D according to the codes and criteria recommended by the WHO. For data collection and analysis, they were processed in the EPIBUCO program, version 2004. Result: At 5 years of age, there was a prevalence of caries in 70% of the children, dmft of 2.98 and a mean of 2.13 deciduous trees in need of restorative intervention, corresponding to 71.44% of dmft. At 12 years of age, a DMFT of 2.20 and a mean of 0.8 permanent teeth in need of restorative intervention per individual were reported, which represents 36.44% of the index. Conclusion: The results show the high prevalence of caries in children from rural schools, thus showing a worse condition than that observed in the Brazilian population, being also below the O.M.S. goals.
Osteomielite Hematogênica Aguda do Punho em Crianças com Síndrome Compartimental: Relato de Caso
Authors: Resende Giovanna Medeiros , Cruz Mário Augusto Ferreira , Machado Carla Pérez , Rezende Luis Guilherme Rosifini Alves , Pavione Tatiana Silveira Santiago
Published: November 2022

A osteomielite hematogênica aguda (OHA) é uma condição relativamente comum em crianças menores de 5 anos, mais frequentemente localizada no fêmur ou na tíbia. Apresentamos um caso incomum de paciente atendido em um hospital da rede privada de saúde em Aracaju-SE com OHA de rádio distal complicada com abscesso subperiosteal e síndrome compartimental. O relato clínico reafirma a importância do diagnóstico e tratamento precoces visto que maior parte das complicações estão relacionadas ao longo prazo da infecção, dentre elas o abscesso subperiosteal e a síndrome compartimental.
Are different responses related to the different affective features? CHAID analysis study
Authors: ÖZYETER Neslihan Tuğçe
Published: November 2022

In education, examining students' learning in detail, determining their strengths and weaknesses and giving effective feedback have gained importance over time. The aim of this study is to determine the distribution of students’ answers to the reading comprehension achievement test items which were written at different cognitive levels and to investigate the affective variables that are effective in classifying students based on their incorrect, blank, and unrelated answers identified via rubric. For this purpose, a reading comprehension achievement test, a student information form, the perceived academic self-efficacy scale and the learned helplessness tendency scale were used to collect data. The student information form included perseverance, achievement motivation, exposure to bullying and test anxiety subscales. A rubric was used to determine the students’ response categories. According to the findings of the study, the rate of blank and incorrect answers increases as the cognitive level of the items become more complex. While the most correct response rates are decreasing, partially-correct answers are increasing relatively. While students' learned helplessness tendencies were effective in classifying their blank and unrelated answers at the most basic reading comprehension level, as the cognitive process became more complex, the affective characteristics classifying the student responses increased in number. It was concluded that these variables are important in improving the students’ answers and in leading them to the partially correct and the most correct answer. It can be suggested to create trainings and classroom environments that will equip and improve students’ features about these variables.