bluuebunny/crossref_metadata_2025 huggingface dataset:
METHOD DEVELOPMENT AND VALIDATION OF SIMULTANEOUS ESTIMATION OF PREGABALIN AND ETORICOXIB IN BULK AND PHARMACEUTICAL DOSAGE FORM BY UV-VISIBLE SPECTROSCOPY
Authors:   Department of Pharmaceutical Analysis, Grace College of Pharmacy, Kodunthirapully -678 004, Palakkad, Kerala, India, B. Akhil M. , Kutty Sheeja V. , Haribabu Yellina , K Nihila
Published: August 2023

A simple, accurate, precise and economical method has been developed for the simultaneous estimation of pregabalin and etoricoxib in combined dosage form by using double point standardization method. Methanol is used as the solvent and chromogenic agent added was bromocresol green. Bromocresol green is only reactive with pregabalin form a green colour ion pair complex. l max of pregabalin and etoricoxib was at 618 nm and 235 nm, respectively. The method was found to be linear in the range of 6-22 µg mL-1 for pregabalin and 4.8-17.6 µg mL-1 for etoricoxib. Validation parameters was performed and method was found to be linear, accurate, precise, rugged and robust.
CHEMOMETRICS OPTIMIZED GREEN LIQUID CHROMATOGRAPHY METHOD FOR SIMULTANEOUS ESTIMATION OF PREGABALIN AND ETORICOXIB IN COMBINED TABLET FORMULATION
Authors:   Department of Pharmaceutical Analysis & Quality Assurance, Roland Institute of Pharmaceutical Sciences, Berhampur- 760 010, Odisha, India, Panda Sagar S. , Routa Pratap C. , Bera Ravi Kumar V.V.
Published: August 2023

Pregabalin and etoricoxib have been recently approved as a potent fixed-dose combination to treat patients with neuropathic back pain effectively. The present investigation quantified both drugs by using a liquid chromatography method using principles of analytical quality-by-design. We assessed the risks, sorted critical method variables and studied their influence on critical analytical attributes using the BoxBehnken design. The optimal chromatographic solutions used acetonitrile: 10 mMol L-1 phosphate buffer of pH 3.51 (70:30 V/V) as the mobile phase. A C-18 column (250 mm × 4.6 mm, 5 µm) with mobile phase flow at 0.9 mL min-1 was used to achieve separation. The developed method's specificity, linearity, accuracy and precision were fair. Furthermore, the method was selective and recovered both analytes to their maximum extent. Additionally, the national environmental methods index approach revealed superior method greenness of the used method for routine quantification of pregabalin and etoricoxib from pharmaceutical samples.
BIOASSAY GUIDED HEPATOPROTECTIVE ACTIVITY OF POLYGONATUM CIRRHIFOLIUM AGAINST ISONIAZID AND RIFAMPICIN INDUCED HEPATOTOXICITY IN RATS
Authors:   Department of Pharmaceutical Chemistry, KIET School of Pharmacy, KIET Group of Institutions, Delhi-NCR, Ghaziabad - 201 206, Uttar Pradesh, India, Grover Parul , Ghai Roma , Nagarajan K. , Kumar Vinay , Goel Richa , Kaur Charanpreet , Chauhan Reenu
Published: August 2023

The present investigation was performed to examine the hepatoprotective effect of the aqueous ethanolic extract of Polygonatum cirrhifolium in antitubercular drug-induced liver damage. P. cirrhifolium rhizomes were crushed, dissolved in various solvents (in order of polarity), and then tested for phytochemicals. Based on their findings, mass extraction utilizing the ethanol-water mixture (50: 50) was carried out using the Soxhlet method. The doses for animal research were established through acute toxicity tests. The hepatoprotective potential of aqueous ethanolic extract (50:50) of rhizomes was determined in Wistar rats at doses of 200 mg kg-1 and 400 mg kg-1 p.o. per day. Blood samples were examined for the biochemical markers SGOT, SGPT, ALP, total bilirubin, and albumin. Histopathology of the liver was also conducted followed by in vitro anti-oxidant studies. Simultaneously, the extract was subjected to LCMS characterization. P. cirrhifolium extract at both the doses 200 mg kg-1 and 400 mg kg-1 has shown significant hepatoprotective activity against hepatotoxicity induced by INH+ RIF in a dose-dependent manner, as depicted by the significant changes in the values of blood biomarkers and in vitro anti-oxidant studies. Histopathological studies showed that the treatment with 200 mg kg-1 and 400 mg kg-1 of P. cirrhifolium exhibited regeneration of liver architecture and portal system by reducing the haemorrhage and inflammatory infiltrate. LC-MS characterization showed serpentine, 5-hydroxy methylfurfural and cephalotaxine as active constituents. It can be inferred that hydroethanolic extract of P. cirrhifolium protects the liver from anti-TB induced toxicity and this protection could be due to the active phytoconstituents.
FEASIBILITY OF ZEBRAFISH LARVA MODEL AS A VIABLE SUBSTITUTE TO RAT NON-EVERTED SAC MODEL FOR PERMEATION EVALUATION OF BCS III DRUGS
Authors: Devarajan Padma V. , Joshi Bhagyashri ,   Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Deemed University, Elite Status and Centre of Excellence (Maharashtra), N.P. Marg, Matunga East, Mumbai- 400 019, Maharashtra, India
Published: August 2023

The oral route is the most convenient route of drug administration. Many drugs exhibit poor oral bioavailability. BCS III drugs exhibit high solubility and present a massive challenge due to poor permeability. Different permeation enhancers viz., nonionic Cremophor® RH 40, Tween® 80 and Lutrol® F68, anionic docusate sodium with sodium cholate, and anionic polymer sodium carboxymethyl cellulose were evaluated using rat non-everted sac method and zebrafish larva model. Maximum permeation enhancement was seen with docusate sodium for both drugs. The permeation enhancement ratio for netilmicin sulphate was 4.07±0.657, while for deferoxamine mesylate it was 1.482±0.378. Cremophor® RH 40 enabled augmented flux of netilmicin sulphate, and Tween® 80 showed enhanced permeation of deferoxamine mesylate. An excellent correlation was observed between apparent permeability and flux with drug absorbed per zebrafish larva (µg) (R2 = 0.938) for netilmicin sulphate and for deferoxamine mesylate (R2 = 0.9397). An important outcome of the study is the demonstration of the feasibility of the zebrafish larvae model as a viable substitute to the non-everted sac method, which could also enable screening of potential permeation enhancers for the development of orally bioavailable formulations of BCS III.
IT IS TIME TO TAKE ADVANTAGE OF IN VITRO CELL BASED MODELS
Authors: Johnson T. Sudhakar ,   Guest editor & Head, Technical (Phytopharma) Viridis BioPharma Pvt. Ltd.
Published: August 2023

Dear Reader, Preclinical tests are crucial for assessing the toxicity and safety of new drugs before moving on to evaluating their efficacy and immunogenicity. Animal models, as well as alternatives, have long been used to study human biology and pathology. However, animal experimentation has been restricted in recent years due to increasing complexities in animal usage and growing concerns about animal welfare groups. There have been ethical concerns raised about the unnecessary or excessive use of experimental animals. As a result, many jurisdictions, including the Indian government, the European Union (EU), the United States, Canada, and South Korea, have restricted usage of experimental animals. Another reason for the limitation of using animals in experiments is uncertainty of results. According to one study, 90% of experimental drugs fail clinical trials, implying that they do not accurately reflect human physiology. The Indian government recently amended the New Drugs and Clinical Trials 2023 (NDCT) Act aimed at fostering the replacement, reduction and refinement of animal testing and the use of non-animal and human-relevant methods to assess the safety and efficacy of new drugs.
Effect of Strength Conditioning on the Playing Skills of Sepaktakraw Athletes Universitas Pahlawan Tuanku Tambusai
Authors: Jufrianis
Published: August 2023

The  purpose  of  the study. The purpose of this study was to determine the extent of the effect of strength conditioning training on the playing skills of sepak takraw athletes at Pahlawan Tuanku Tambusai University.

Materials and methods. The method used is path analysis research method to see the direct influence between variable X on variable Y with a population and sample of 25 people. The data in this study are the results of strength and physical fitness conditioning tests which were analyzed using test requirements path analysis techniques.

Results. The results of the research that has been conducted on the strength and conditioning variables on the physical fitness level of the Sepak Takraw Athletes at the University of Pahlawan Tuanku Tambusai found a direct influence between strength and conditioning (X1) the playing skills of the Sepak Takraw Athletes at the University of Pahlawan Tuanku Tambusai of 0.721. This can be seen in the Coffesient Table which shows the value of sig. 0.000. It turns out that the value of sig. 0.000 is smaller than the probability value of 0.05 or a value of 0.05 > 0.000, so it can be concluded that strength and conditioning have a direct effect on the playing skills of Sepak Takraw Athletes at Hero University Tuanku Tambusai.

Conclusions. The Conclusion From the test results show that physical strength is very influential on the skills of playing Sepak Takraw on the athletes of the Hero University Tuanku Tambusai.
Comparison of photocell and stopwatch time in a 20 meter sprint: A case study of a non-trained analyst
Authors: Loureiro Ivo , Moreira Ruben , Silva Ruben , Sampaio João , Teixeira Tiago , Lourenço Rodrigo , Branquinho Luís , Flores Pedro , Fortunato Alvaro , Forte Pedro
Published: August 2023

The purpose of the study. Running speed represents a global marker of individual performance and provides a simple method of objective measurement of motor performance for use in clinical and research environments. Speed is most often at relatively short distances at normal or fast pace, using methods of obtaining manual time (e.g., stopwatch) or automated (e.g., photocells).

Materials and methods. The sample consisted of 25 students, 12 males and 13 females, all 13 years old and walked a course 20 meters away, we used to obtain the time elapsed the time, and the method by photocells. The agreement was examined using Bland and Altman graphs and linear regression.

Results. There are significant and strong differences between the evaluation methods (T =14,205; p<0,001) and there is a significant and strong correlation between the variables (r = 0.902; p<0.001).

Conclusions. This study suggests that for measurement in research context or in sports aimed at high yield it is advisable to use photocell, and the use of the timing method for recreational use.
Early release as an element of a progressive system of serving a sentence
Authors: Санташов А.Л.
Published: August 2023

В статье рассматриваются виды оснований досрочного освобождения в контексте их стимулирующего воздействия на поведение осужденных. Анализируются мнения ученых о правовой природе и составе прогрессивной системы отбывания наказания. Отмечается главенствующая роль воспитательной работы, а именно мер поощрения, которые изменяют правовое положение осужденных, в досрочном формировании у них уважительного отношения к человеку, обществу, труду, нормам стимулировании их правопослушного поведения. Количественные и качественные характеристики мер поощрения являются показателем эффективности воспитательной работы. В итоге делается вывод о том, что только являющиеся законным интересом основания досрочного освобождения являются стимулом к правомерному поведению осужденных, тем самым проявляют себя в качестве элемента прогрессивной системы. Предлагаются некоторые изменения в действующее уголовно-исполнительное законодательство, которые позволят более наглядно отобразить важнейший законный интерес осужденных — досрочное освобождение, что в свою очередь позитивно отразится на стимулировании правопослушного поведения.

This article examines the types of grounds for early release in the context of their stimulating effect on the behavior of convicts. The opinions of scientists on the legal nature and composition of the progressive system of serving sentences are analyzed. The predominant role of educational work, namely incentive measures that change the legal status of convicts, is noted in the early formation of their respectful attitude to a person, society, work, and the norms of stimulating their law-abiding behavior. Quantitative and qualitative characteristics of incentive measures are an indicator of the effectiveness of educational work. As a result, it is concluded that only the grounds for early release, which are a legitimate interest, are an incentive to the lawful behavior of convicts, thereby manifesting themselves as an element of a progressive system. Some amendments to the current penal enforcement legislation are proposed, which will allow more clearly displaying the most important legitimate interest of convicts — early release, which in turn will have a positive impact on stimulating law–abiding behavior.
The penal characteristics of detention and problems of implementation of the educational colony regime
Authors: Тепляшин П.В.
Published: August 2023

В статье раскрывается определение режима исправительного учреждения в широком и узком смысле и демонстрируется основная направленность режима в воспитательных колониях. Рассматриваются правоограничения и функции режима. Через призму прогрессивной системы исполнения наказания показан механизм реализации обычных, облегченных, строгих и льготных условий в воспитательной колонии. Изложены критерии, на основе которых разграничиваются данные условия отбывания наказания несовершеннолетними осужденными. Обозначены отдельные организационно-правовые проблемы реализации порядка исполнения и отбывания лишения свободы несовершеннолетними лицами. В контексте применения мер поощрения и взыскания освещены некоторые дискуссионные вопросы уголовно-исполнительного характера. Изложены особенности обеспечения режимных требований. Сформулирован вывод о перспективах оптимизации общественных отношений, существующих в сфере исполнения и отбывания несовершеннолетними лишения свободы.

The article reveals the definition of correctional regime in a broad and narrow sense and demonstrates the main focus of the regime in educational colonies. The law-restrictions and functions of the regime are examined. The mechanism of realization of regular, light, strict and preferential conditions in educational colony is shown through the prism of progressive system of execution of punishment. The criteria on the basis of which these conditions are distinguished for the serving of sentences by juvenile inmates are set out. Separate organizational and legal problems of implementation of the procedure of execution and serving of imprisonment by juveniles are outlined. Some debatable issues of penal nature are highlighted in the context of the application of incentives and penalties. The specific features of the regime’s requirements are outlined. The conclusion about the prospects of optimization of social relations existing in the sphere of execution and serving of imprisonment by juveniles is formulated.
Humanization of the regime in correctional institutions of the Republic of Belarus
Authors: Шабаль В.С.
Published: August 2023

В статье обозначены основные подходы к содержанию и функциям установленного порядка исполнения и отбывания наказания в виде лишения свободы на определенный срок. Проведен анализ позиций авторов на данную проблему в Республике Беларусь и Российской Федерации. Делается вывод, что существующий режим в исправительных учреждениях Республики Беларусь не соответствует целям уголовной ответственности и требует корректировки в части гуманизации процессов исполнения наказания. Все это обусловливает актуальность исследования режима в исправительных учреждениях. Установлено, что многие правоограничения, а также сами по себе условия отбывания наказания включают в себя кару преступника за совершенное преступление, не способствуя при этом реализации целей применения наказания. Автором предлагается подвергнуть комплексному и системному пересмотру установленный порядок исполнения и отбывания наказания в виде лишения свободы на определенный срок в целях гуманизации условий отбывания наказания, включая оборудование учреждений, расширение правового статуса осужденных, получения ими посылок, предоставления свиданий и прочее. Результаты, полученные в ходе исследования, могут быть использованы как в правоприменительной практике исправительных учреждений, так и в качестве разработки законопроекта о внесении соответствующих изменений в Уголовно-исполнительный кодекс Республики Беларусь.

The article outlines the main approaches to the content and functions of the established procedure for the execution and serving of a sentence in the form of imprisonment for a certain period. An analysis of the positions of the authors on this problem in the Republic of Belarus and the Russian Federation was carried out. It is concluded that the existing regime in correctional institutions of the Republic of Belarus does not correspond to the goals of criminal liability and requires adjustment in terms of the humanization of the processes of execution of punishment. It has been established that many legal restrictions, as well as the conditions of serving a sentence themselves, include punishing the offender for the crime committed, while not contributing to the implementation of the goals of the application of punishment. The author proposes to subject a comprehensive and systematic review of the established procedure for the execution and serving of a sentence of imprisonment for a certain period in order to humanize the conditions for serving a sentence, including the equipment of institutions, expanding the legal status of convicts, receiving parcels, providing visits, etc.
The place of accounting and registration activities of the penal system in the system of information support for the investigation of crime
Authors: Кремлев М.В. , Волков Д.Ю.
Published: August 2023

В статье дана оценка некоторым существующим механизмам получения информации, возникающей в процессе отбывания и исполнения наказания. Предложено разделять данную информацию на три большие группы, отражающие конкретные виды уголовно-исполнительной деятельности. Отмечена важность указанных групп информации для должностных лиц органов предварительного расследования как на этапе возбуждения уголовного дела, так и в процессе его производства. Приведенный тезис подтвержден сравнительным анализом качества информации, возникающей в процессе исполнения уголовного наказания, с теоретическими положениями криминалистической науки и содержанием действующего уголовно-процессуального законодательства. Дополнительным аргументом выступает проведенное анкетирование, а также опрос следователей и дознавателей. Установлена важность обращения к информационным ресурсам УИС. Выявлены основные проблемы получения криминалистически значимой информации из информационно-справочных систем УИС. Указанные проблемы носят технический и нормативно-правовой характер. С учетом современных технических возможностей предложены основные направления деятельности по совершенствованию информационного взаимодействия между различными ведомствами.

This article assesses some of the existing mechanisms for obtaining information that arises in the process of serving and executing a sentence. It is proposed to divide this information into three large groups, reflecting specific types of penitentiary activities. The importance of these groups of penitentiary information for officials of the preliminary investigation bodies, both at the stage of initiating a criminal case and in the process of its production, is noted. The above thesis is confirmed by a comparative analysis of the quality of penitentiary information with the theoretical provisions of forensic science and the content of the current criminal procedure legislation. An additional argument is the survey conducted, as well as a survey of investigators and interrogators. The importance of accessing the information resources of the penal system has been established. The main problems of obtaining forensically significant information from the information and reference systems of the penal system are identified. These problems are of a technical and regulatory nature. Taking into account modern technical capabilities, the main directions of activity to improve information interaction between various departments are proposed.
Operational-search prevention in the execution of punishment in the form of deprivation of liberty: concept and features
Authors: Иваньков И.А.
Published: August 2023

В статье рассматриваются вопросы оперативно-розыскной профилактики в оперативно-розыскном обеспечении исполнения и отбывания наказания в пенитенциарной системе России. Высказаны суждения относительно возможности проведения оперативно-розыскных мероприятий оперативными подразделениями исправительных учреждений с целью профилактики правонарушений при исполнении и отбывании наказания в виде лишения свободы. Отмечается недостаточная теоретическая проработка дефиниции «оперативно-розыскная профилактика» применительно к практике деятельности оперативных подразделений уголовно-исполнительной системы России на современном этапе. На основе анализа, существующих научных определений данного направления деятельности оперативных подразделений уголовно-исполнительной системы, законодательства, регламентирующего профилактику в Российской Федерации, а также полномочий субъектов оперативно-розыскной деятельности при исполнении наказания в виде лишения свободы предлагается авторская дефиниция понятия пенитенциарной оперативно-розыскной профилактики.

The article considers the issues of operational-search prevention in operational-search enforcement and serving sentences in the penitentiary system of Russia. The author made judgments about the possibility of conducting preventive-search activities by operational units of correctional institutions in order to prevent offenses in the execution and serving of sentences in the form of imprisonment. There is an insufficient theoretical definition of operational-search prevention in relation to the practice of the operational units of the penitentiary system of Russia at the present stage. Based on the analysis, existing scientific definitions of this area of activity of the operational units of the penal system, legislation regulating prevention in the Russian Federation, as well as the powers of the subjects of operational-search activity in the execution of punishment in the form of imprisonment, an author’s definition of the concept of penitentiary operational-search prevention is proposed.
On the issue of preventing the commission of new crimes by those sentenced to deprivation of liberty as the goal of penal legislation
Authors: Бочкарев В.В. , Горбань Д.В.
Published: August 2023

В статье рассматривается вопрос законодательного оформления юридической конструкции предупредительного воздействия уголовно-исполнительного законодательства. Анализируется предупредительное воздействие на осужденных в правовых актах советского периода, определяется значение и роль данного процесса в учреждениях, исполняющих наказания, связанные с изоляцией. Проводится анализ общего законодательства в области предупредительного воздействия, реализуемого в рамках всех правоохранительных органов. Рассматриваются ведомственные нормативные правовые акты, определяющие предупредительное воздействие на осужденных к лишению свободы, а также указания, обзоры, методические рекомендации и письма, подготовленные профильными управлениями ФСИН России для реализации предупредительного воздействия на осужденных к лишению свободы. Анализируется исправительное направление уголовно-исполнительного законодательства на уровне целей, задач, принципов, средств и предмета уголовно-исполнительного законодательства. Рассматривается предупреждение совершения осужденными новых преступлений в уголовно-исполнительном законодательстве стран ближнего зарубежья. Предлагается закрепить предупреждение совершения преступлений в рамках системы средств, принципов, задач и предмета уголовно-исполнительного законодательства.

The article considers the issue of legislative registration of the legal structure of the preventive impact of penal legislation. The preventive effect on convicts in the legal acts of the Soviet period is analyzed, the meaning and role of this process in institutions that carry out punishments related to isolation is determined. An analysis of the general legislation in the field of preventive impact is being carried out within the framework of all law enforcement agencies. Departmental regulatory legal acts are considered that determine the preventive effect on convicts to imprisonment, as well as instructions, reviews, guidelines and letters prepared by the relevant departments of the Federal Penitentiary Service of Russia for the implementation of the preventive effect on convicts to imprisonment. The correctional direction of penal law is analyzed at the level of goals, tasks, principles, means and subject matter of penal law. The prevention of new crimes committed by convicts in the penal legislation of neighboring countries is being considered. It is proposed to consolidate the prevention of crimes within the framework of the system of means, principles, tasks and the subject of criminal law.
XXII All-Russian Scientific and Practical Conference “Penal system today: interaction of science and practice”
Authors: Чириков А.Г.
Published: August 2023

19–20 октября 2022 г. состоялась XXII ежегодная всероссийская научно-практическая конференция «Уголовно-исполнительная система сегодня: взаимодействие науки и практики» — традиционное мероприятие, проводимое Кузбасским институтом ФСИН России. В мероприятии приняли участие ведущие ученые научных и образовательных организаций Федеральной службы исполнения наказаний, Министерства внутренних дел, Федеральной службы войск национальной гвардии и Министерства науки и высшего образования Российской Федерации, руководители и практические работники территориальных органов ФСИН, МВД России, судов, прокуратуры, адвокатуры, министерства науки и высшего образования Кузбасса, образовательных организаций города Новокузнецка, общественных и иных организаций. В публикации кратко изложены цели и задачи мероприятия, охарактеризован круг участников конференции, представлены основное содержание наиболее ярких и содержательных докладов, тематика секционных заседаний и круглых столов, проведенных в рамках мероприятия.

On October 19-20, 2022, the XXII annual All-Russian scientific and practical conference “Penal System Today: Interaction of Science and Practice” was held, it’s a traditional event held by the Kuzbass Institute of the Federal Penal Service of Russia. The event was attended by leading scientists of scientific and educational organizations of the Federal Penal Service, the Ministry of Internal Affairs, the Federal Service of the National Guard and the Ministry of Science and Higher Education of the Russian Federation, heads and practitioners of the territorial bodies of the Federal Penal Service, the Ministry of Internal Affairs of Russia, courts, prosecutors, lawyers, the Ministry of Science and Higher Education of Kuzbass, educational organizations of the city of Novokuznetsk, public and other organizations. The publication summarizes the goals and objectives of the event, describes the circle of conference participants, presents the main content of the most striking and meaningful reports, the topics of sectional meetings and round tables held within the framework of the event.
Legal innovations of the Internal Regulations for Detention Centres of the penal System of the Russian Federation, 2022
Authors: Закаржевский Н.Н.
Published: August 2023

В статье приведена позиция автора по отдельным правовым проблемам в части реализации нововведений в принятых в 2022 г. Правилах внутреннего распорядка следственных изоляторов уголовно-исполнительной системы РФ (далее — Правила СИЗО). На основе проведенного статистического и правового исследования положений новых Правил СИЗО в сравнении с предыдущими Правилами СИЗО и иными нормативно-правовыми актами установлены некоторые положительные нововведения, а также отдельные недостатки, как правового, так и технического характера. Предлагаются соответствующие изменения и дополнения.Материал способствует пониманию новых аспектов принятых Правил СИЗО, а также их грамотной реализации в правоприменительной деятельности.

The article points out the author’s position on certain legal problems in terms of the implementation of innovations in the adopted in 2022 Rules of internal regulations of remand prisons of the criminal executive system of the Russian Federation (hereinafter — Rules). On the basis of the conducted statistical and legal study of the provisions of the new Rules in comparison with the previous Rules of remand centres and other normative legal acts some positive innovations as well as certain drawbacks of both legal and technical nature are established. Appropriate amendments and additions are suggested. The material contributes to the understanding of the new aspects of the adopted Rules, as well as their proper implementation in law enforcement activities.
About the directions of development of public-private partnership in the penal sphere as a way of implementing public influence in relation to convicts
Authors: Малолеткина Н.С. , Скиба А.П.
Published: August 2023

В статье на основе анализа теории и законодательства делается вывод о необходимости разработки теоретико-правовых аспектов в целом общественного воздействия как средства исправления осужденных и, в частности, государственно-частного партнерства в пенитенциарной сфере как способа его реализации. Выделяется ряд направлений развития государственно-частного партнерства в пенитенциарной сфере: пересмотр теоретических, организационных и правовых аспектов привлечения осужденных к труду, включая разработку концепции права осужденных на труд, в том числе на занятие предпринимательской деятельностью; создание частных учреждений и их отдельных «негосударственных» участков (медицинских, производственных и пр.); привлечение осужденных для заселения недостаточно обжитых территорий России, а также их инфраструктурного и экономического развития; расширение получения осужденными образования, включая высшего, в том числе в негосударственных образовательных организациях; внедрение медиативных технологий, в том числе с привлечением саморегулируемых организаций; расширение взаимодействия с религиозными организациями, а также более четкое определение правового положения всех участников реализации права осужденных на свободу совести и вероисповедания; обеспечение соблюдения прав осужденных путем реализации общественного контроля.

Based on the analysis of theory and legislation, the article concludes that it is necessary to develop theoretical and legal aspects of public influence in general as a means of correcting convicts and, in particular, public-private partnership in the penitentiary sphere as a way of its implementation. A number of directions for the development of public-private partnership in the penitentiary sphere are highlighted: the revision of the theoretical, organizational and legal aspects of attracting convicts to work, including the development of the concept of the right of convicts to work, including to engage in entrepreneurial activity; the creation of private institutions and their separate “non-state” sites (medical, industrial, etc.); the involvement of convicts for the settlement of insufficiently inhabited territories of Russia, as well as their infrastructural and economic development; expansion of education by convicts, including higher education, including in non-governmental educational organizations; introduction of mediation technologies, including with the involvement of self-regulating organizations; expansion of interaction with religious organizations, as well as a clearer definition of the legal status of all participants in the realization of the right of convicts to freedom of conscience and religion; ensuring compliance with the rights of convicts through the implementation of public control.
Exemption from criminal liability and punishment after changing the category of crime to a lesser one
Authors: Беларева О.А.
Published: August 2023

В статье рассматриваются вопросы, касающиеся уголовно-правовых последствий применения судом положений ч. 6 ст. 15 УК РФ. Автор проследил эволюцию взглядов Пленума Верховного Суда РФ на возможность освобождения от уголовной ответственности и наказания после изменения категории преступления с тяжкого на средней тяжести, отметил недостатки некоторых рекомендаций, проанализировал влияние позиции высшего судебного органа на судебную практику. В работе отмечается, что разъяснения Пленума ВС РФ не привели к единообразию судебной практики, поскольку ни уголовное, ни уголовно-процессуальное законодательство не содержат оснований для освобождения как от уголовной ответственности, так и от наказания при изменении категории преступления. В статье приводятся примеры судебной практики, отражающие многообразие способов процессуального оформления принимаемых судами решений, показано, что судьи, по разному оценивая объем правовых последствий изменения категории преступления, затрудняясь с мотивировкой основания и правовой сущности освобождения в выносимом решении, не видя законных способов выполнения рекомендаций высшего судебного органа, пытаются выбирать из незаконных решений «менее незаконное». Автором представлен обзор предложений по совершенствованию уголовного законодательства и практики его применения в части освобождения от уголовной ответственности и наказания после изменения категории преступления на меньшую.

The article discusses issues concerning the criminal consequences of the court’s application of the provisions of Pt. 6 of Art. 15 of the Criminal Code of the Russian Federation. The author traced the evolution of the views of the Plenum of the Supreme Court of the Russian Federation on the possibility of exemption from criminal liability and punishment after changing the category of crime from grave to moderate, noted the shortcomings of some recommendations, analyzed the influence of the position of the supreme judicial body on judicial practice. The paper notes that the explanations of the Plenum of the Supreme Court of the Russian Federation did not lead to uniformity of judicial practice, since neither criminal nor criminal procedure legislation contains grounds for exemption from both criminal liability and punishment when changing the category of crime. The article provides examples of judicial practice reflecting the variety of ways of procedural registration of decisions made by courts, it is shown that judges, differently assessing the scope of legal consequences of changing the category of crime, finding it difficult to motivate the grounds and legal essence of the release in the decision, not seeing legitimate ways to implement the recommendations of the supreme judicial authority, try to choose from illegal decisions “less illegal”. The author presents an overview of proposals for improving criminal legislation and the practice of its application in terms of exemption from criminal liability and punishment after changing the category of crime to a lesser one.
COVID-19 vaccination hesitancy and associated factors among the business community in Lira City, Uganda: a cross-sectional research
Authors: Kigongo Eustes , Achan Everlyne , Opio Bosco , Akello Anne Ruth , Musinguzi Marvin , Tumwesigye Raymond , Kabunga Amir , Puleh Sean Steven
Published: August 2023

Background: As of November 26, 2021, at least seven different vaccines across three platforms have been distributed globally. These vaccines include Pfizer/BioNTech released on December 31, 2020, AstraZeneca on February 16, 2021, Janssen by Johnson and Johnson on March 12, 2021, Moderna on April 30, 2021, Sinopharm on May 7, 2021, Sinovac CoronaVac on July 1, 2021, and COVAXIN on November 3, 2021. Despite this unprecedented scientific discovery, vaccine hesitancy is seen as a stumbling block towards achieving herd immunity in the battle to control this global pandemic. The effectiveness of vaccines has been based on the principle that the community was willing to take up the vaccine to achieve herd immunity. This study aimed to assess COVID-19 vaccination hesitancy and associated factors among the business community in Lira City, Uganda.Methods: Descriptive cross-sectional design was conducted among the business community from Lira City in Northern Uganda. The sample size was 421, however, only 407 members of the business community who responded were included in the analysis.Results: Of the 407 participants, 57.3% were females, 52.5% were married, 88.4% were Langi by Tribe, 43.5% had tertiary education, 33.4% were Anglicans, and 40.1% were market vendors. Results also show that about 32.3% of the respondents had either delayed or refused to take the COVID-19 vaccine. The correlates of vaccination hesitance were education level (aOR; 3.63, 95%CI; 1.49-8.79, p=0.04), having a chronic medical condition (aOR; 2.7, 95%CI; 1.39-5.38, p=0.04) and certainty in the COVID-19 vaccines (aOR; 0.27, 95%CI; 0.017-0.51, p=0.02). Respondents who had primary level education had a more than 2-fold increased odds of acceptance of COVID-19 vaccination compared to those who had not attained any formal education. Individuals who had chronic medical conditions had more than 2-fold increased odds of accepting the COVID-19 vaccine compared to those who did not have any chronic medical conditions. Those who were certain about the COVID-19 vaccine were 73% less likely to hesitate vaccination as compared to their counterparts who were uncertain. Conclusion: The study found a substantially high level of COVID-19 vaccination hesitancy in Lira City and its predictors were level of education, chronic medical conditions and certainty in COVID-19 vaccines. For this reason, it is important to raise awareness among the business community about the vaccine. To increase uptake, policymakers and other stakeholders need to create effective communication techniques for behavior change.
CLINICAL FEATURES AND OUTCOMES OF PATIENTS WITH METASTATIC BREAST CANCER
Authors: RASHID AA , TOOR MT , MUNIR AB , ABRO NA , SHAFIQ B
Published: August 2023

The retrospective study was conducted in the Department of Oncology, Hameed Latif Hospital, JPMC & GINUM, from January 2020 to January 2023 to assess the shift in the prognosis of MBC over time in the real-life clinical setting. Patients were divided into groups based on disease diagnosis (Group I: January 2020-January 2021 and Group II: January 2022-January 2023) and disease presentation (de novo vs. recurrent), and the correlation between prognostic factors and survival was assessed. A total of 781 patients were included in the study, 240 in Group I and 541 in Group II. There were 484 (61.9%)  HR+, 210 (26.8%) HER2+, and 86 (11.01%)  TN cases. 412 (53%) had recurrent disease, with a gradual increase in frequency (P <0.001). Incidence of HR+ disease (56%) was significantly higher than HER2+(20%) and TN subtypes (12%)(P<0.001). 375 (48%) had dnMBC, consisting of 52%  with HR+ disease, 29% withHER2+ and 5.8% having TNMBC. Despite a gradual decrease in frequency, de novo disease was most common in the HER2+ subtype (62% in Group I vs. 49% in Group II, P = 0.007). A higher number of subjects with HR+ disease had chemotherapy in Group I compared to Group II (P=0.01), while endocrine therapy (ET) was more common in Group II (n = 238, 44%) compared to Group I (n = 118; 38.4%) (P=0.14). There were significant variations among pathological subtypes; HR+ was 18.0 months,  HER2+ was 17.0 months, and  TNBC was 10 months ( P< 0.001). The median OS among all patients after a follow-up of 36 months was 50.0 (47.0-54.0) months. TN group had the worst OS of 27 months (P<0.001). The impact of modern treatment approaches in Group I vs. Group II (52 vs. 52 months) was insignificant. Advancement in the treatment is associated with improved prognosis of MBC, particularly for luminal B-HER2+. TNBC has the worst prognosis and is the most challenging to treat. The findings of this study will provide insight into disease patterns and survival, which can be valuable for improving outcomes through the use of novel treatment.
Apresentação do Dossiê: Continuidades Esquecidas e Rupturas Construídas entre Ditaduras e Democracias
Authors: Azevedo Ana Carina
Published: August 2023

Independentemente do modo como se processaram, as mudanças de regime político são, por norma, analisadas sob a lente da ruptura, sendo dada uma atenção insuficiente aos elementos de continuidade presentes nos mais variados níveis. Neste texto de apresentação são abordadas algumas das questões teóricas subjacentes aos estudos apresentados no dossiê temático. São destacadas as problemáticas ligadas à divisão do tempo histórico e os impactos das escolhas relativas à definição das balizas cronológicas dos trabalhos de investigação; as questões que envolvem as noções de continuidade e mudança; e a centralidade destes temas nos estudos sobre transições políticas. Argumenta-se que o modo como o passado é interpretado é devedor da forma como estas problemáticas são ou não incorporadas e problematizadas pelos pesquisadores. No final, conclui-se que uma análise transversal entre regimes políticos permite esbater rupturas fictícias e identificar continuidades escondidas, transformando a nossa compreensão sobre o passado e sobre o seu impacto no presente.
The Use of the Lateral Tibial Line to Assess Ankle Alignment: A Preliminary Investigation
Authors: Striano Brendan M. , Patel Shalin S. , Parker Emily , Vaughn Joshua J. , Smith Jeremy T. , Harris Mitchel B. , Chiodo Christopher P.
Published: August 2023

Background:

Although the medial clear space (MCS) is commonly used to assess talar alignment and ankle stability, its measurement is variable with multiple reported normal values. We have observed that the lateral tibial shaft is a reliable landmark to assess talar alignment. The objective of the current investigation was to determine the normal relationship of the lateral tibia to the superolateral talus using a tangent drawn inferiorly from the lateral tibial shaft, which we refer to as the “lateral tibial line” (LTL).

Methods:

The relationship of the LTL to the superolateral talus was assessed by three reviewers on 99 standing ankle mortise radiographs in uninjured patients. This relationship was quantified by measuring the distance (in millimeters) between the LTL and the superolateral talus. In addition, the interobserver reliability of the LTL measurement was recorded and compared with that of the MCS.

Results:

The median value for the distance between the superolateral talus and LTL was −0.50 mm with an interquartile range of −1.4 to 0.0 mm. The LTL was within 1 mm of the lateral talus in 176 of 297 reviewer measurements (59.3%). Moreover, it was either lateral to or at most 1 mm medial to the lateral talus in 90.9% of cases. The LTL measurement also demonstrated good interobserver reliability (0.764, 95% confidence interval, 0.670 to 0.834), similar to the measurement of MCS (0.742, 95% confidence interval, 0.539 to 0.846).

Conclusions:

The relationship between the LTL and superolateral talus is easily measured with good reliability for assessing the anatomic relationship of the tibia and talus. The LTL uncommonly fell more than 1 mm medial to the superolateral talus, as might be seen with displaced ankle fractures. These findings will hopefully serve as a basis for future studies evaluating its role in assessing lateral displacement and stability of isolated fibula fractures.

Level of evidence:

Level III, retrospective review.
ANALYSIS OF TALENT POOL MANAGEMENT (TALENT MANAGEMENT) IN IMPROVING ORGANIZATIONAL PERFORMANCE OF PT PLN MAIN UNIT DISTRIBUTION OF NORTH SUMATRA UP3 RANTAUPRAPAT
Authors: Cosine Melvin Sitorus Pane  , Nazaruddin  , Iskandarini
Published: August 2023

Employee performance can optimize the quality and quantity of production with more productive performance. Making employees or employees more able to explore the knowledge and skills needed to achieve company or organizational goals. The effect of talent pool management on organizational performance is a complex research topic, but in general it can be said that good management talent pool has the potential to improve overall organizational performance. Human resource management is carried out using a process of analyzing, developing and utilizing talent in a sustainable and effective way to meet business needs, in other words this is talent management. Talent management according to Wibowo (2020) is a concept that starts from how to plan, acquire, develop,
College English teaching based on peer feedback in writing tasks under the perspective of New Liberal Arts
Authors: Pan Yu
Published: August 2023

This study aims to explore the teaching model of medical universities’ English education based on peer feedback in writing classes under the new liberal arts perspective. Using construstivism as the theoretical framework, the scaffolding theory as the analytical framework, this study employs experimental control methods and utilizes SPSS software for data analysis to evaluate the effectiveness of peer feedback in improving writing abilities. In-depth text analyses of questionnaires and reflection reports are conducted to examine the mediating effects of this strategy on students’ text revision, academic discourse knowledge, cultural literacy, and research awareness, and to investigate how peer feedback contributes to the cultivation of autonomous learning, self-assessment, and critical thinking. The findings confirm that peer feedback not only enhances students’ writing levels but also fosters their deep learning habits. This study provides an effective teaching model that integrates deep learning and ideological education for medical universities’ English instruction based on peer feedback in writing classes under the new liberal arts perspective.
Qualitative Characteristics of Accounting Information (Declared with IFRS Standards) and Financial Performance : Statistical Study and Correlation Test
Authors: Ait Bahabbaz Mohammed , Karim Khaddouj
Published: August 2023

In an international context characterized by the dismantling of economic barriers, the globalization of monetary operations and the fluidity of financial movements, the application of IFRS standards is no longer a luxury, but rather an increasingly persistent necessity for Moroccan and international companies. In this context, and using a statistical analysis on SPSS, this research aims to assess the correlation between the quality of accounting information (declared in accordance with IFRS standards) and the financial performance (in short term and in medium and long term) of Moroccan companies. This quantitative research which uses a Likert-type questionnaire scored from 1 to 5, and through the responses collected from a sample of 314 individuals (composed of accountants, chartered accountants, professors, trainers, doctors and doctoral students), target to demonstrate and verify, statistically, the relationship of correlation and interdependence that connects between « the qualitative characteristics of accounting information » and « the financial performance ». The results confirmed a negative correlation « in the short term » between the aforementioned variables and a positive correlation relationship between the same variables « in the medium and short term ». In the medium and long term, the positive correlation between « the qualitative characteristics of the accounting information declared according to IFRS » and « the financial performance », will probably be a factor that encourages companies to practice international accounting standards despite the costs incurred to ensure this passage.