bluuebunny/crossref_metadata_2025 huggingface dataset:
Tendencias en la estimulación temprana. Estudio de caso en la comunidad Nueva Vida
Authors: Reyes Ruiz María Inmaculada , Rengifo Barciona María Lorena , Nieto Silva Rosa María , Tacuri Mejía Rosa Leonela , González Rivera Pedro Luis
Published: October 2023

A partir de la complejidad de la realidad actual, este libro tiene como objeto de estudio las tendencias principales en la estimulación temprana. Para lograrlo, se exploran los fundamentos que se relacionan con el enfoque social de la educación, se analiza la contraposición entre la escuela tradicional y la escuela activa, se examinan las corrientes pedagógicas más recientes y se considera la perspectiva internacional en el ámbito de la estimulación temprana en Ecuador. Además, se presentan conceptos cruciales acerca del modelo pedagógico del programa aplicado a los niños de la comunidad Nueva Vida de la ciudad de Guayaquil.En este contexto, docentes y estudiantes de Educación Inicial trabajaron arduamente en el marco del programa comunitario para impulsar la formación de los niños más pequeños. Los resultados obtenidos respaldaron estas acciones, convirtiendo este texto en una invitación a priorizar la estimulación temprana en los infantes, con la firme intención de promover su desarrollo como individuos responsables y constructivos.
A fenntartható fejlődés mérési lehetőségei az Európai Unióban az Agenda 2030 indikátorai alapján
Authors: Kozma Dorottya Edina
Published: October 2023

A szerző kutatásának alapját az Agenda 2030 a fenntartható fejlődésért keretprogram mutatószámai alkotják, melyek segítségével a 2014 és 2018 közötti időszakra vonatkozóan vizsgálja a fenntartható fejlődés mérési lehetőségeit az Európai Unióban. A kvantitatív kutatás során olyan különböző statisztikai és ökonometriai módszerek kerültek alkalmazásra, mint a faktoranalízis, korreláció analízis, a skálaösszehangoló transzformációs és a klaszteranalízis. A kutatás fő célja, hogy bemutassa mennyire szerteágazó a fenntartható fejlődés mérésének lehetősége és az, hogy az Agenda 2030 adatbázisának mutatószámai milyen mértékben csökkenthetők a kiválasztott módszerek segítségével.
Performance profile for ILCA class elite sailors. Differences between men and women
Authors: Manzanares Aarón , Encarnación-Martínez Alberto , Chicoy-García Ion , Segado Francisco
Published: October 2023

In sport sailing, there are three fundamental pillars of performance for dinghy sailors (physical condition, cognitive ability and equipment). One of the decisive moments in a single-handed dinghy race is sailing upwind, as it requires a high physical demand from the sailors to keep the boat flat and make the best decisions according to the tactical conditions of the race. The objective of the research is (i) to analyze the performance of elite sailors on the hiking position in a dynamic virtual sailing situation and (ii) to measure the lower body muscle fatigue in the hiking action. The sample consisted of 10 sailors from the Ilca sailing class and belonging to the Olympic teams of the Norwegian, Mexican and Spanish national teams, 6 of them men (Mage=31.67, SDage=6.861) and 4 women, (Mage=30.50, SDage=4.655). The fatigue protocol consisted of a static test and a dynamic test of the sac body position. Both tests measure the sailors’ effort up to extreme fatigue or loss of position. The test was performed on the vSail-Trainer® sailing simulator, which allows to reproduce real sailing conditions and displays data on boat control variables. The results obtained show statistically significant differences between the group of women and men on boat speed (P=0.039), distance sailed (P<0.001) and hiking effort (P=0.002). There are statistically significant differences in lower body power pre and post fatigue test. This does not lead to the conclusion that the simulator is a valid tool to assess fatigue specifically in Ilca class sailors.
Analysis and simulation of turbulent flow around an immersed body with constant temperature using the Immersed Boundary Method
Authors: Santos Rômulo Damasclin Chaves dos , Sales Jorge Henrique de Oliveira
Published: October 2023

In this study, we present an immersed boundary method to analyze interactions between fluids and bodies in two-dimensional (2D) flows around complex geometries, focusing on heat transfer and turbulence. The method uses an Eulerian grid for the fluid, and another Lagrangian grid for the immersed body, ensuring conditions of no slip and considering heat exchanges. We use Navier-Stokes and energy equations with Smagorinsky (LES) and Spalart-Allmaras (URANS) turbulence models. A computational code was implemented to calculate lift, drag and Nusselt coefficients, comparing the results with previous studies at different Reynolds numbers. This research advances the understanding of fluid-body interactions in complex geometries and thermofluid dynamics.
CT and MRI image fusion based on variance and pixel significance
Authors: Latreche Boubakeur
Published: October 2023

In the medical imaging field, images are obtained using various modalities, including the computed tomography procedure and the magnetic resonance imaging procedure. In which every image contains different information from the other image. For better treatment and diagnosis of a patient, a single composite image must be created by fusing all the pertinent data. This process is known as image fusion. We present an innovative and effective image fusion technique utilizing ILWT and DCT for combining brain-related medical images acquired through there are two steps to this strategy. First, the variance is employed as a contrast evaluation in the DCT domain to combine the approximation coefficients generated by the ILWT decomposition. Second, the coefficients representing the fine details are combined by finding the ideal weighted average based on the importance of the pixels in the ILWT domain. Our method is straightforward, making it simple and suitable for deployment in real-time applications. The experimental results demonstrate our method's outstanding performance with regard to both result quality and in contrast to a number of picture fusion techniques.
Inventario de competencias clave para los pilotos de la Fuerza Aérea Colombiana
Authors: Ramírez Segura Bryan , Rodríguez Suárez Carolina
Published: October 2023

La gestión de las amenazas y errores en la aviación militar requiere que los pilotos cuenten con competencias que les permitan tener un desempeño resiliente frente a un entorno altamente demandante, en constante cambio, con condiciones de alto riesgo e incertidumbre. Con el propósito de identificar y estandarizar esas competencias bajo un modelo distintivo para la Fuerza Aérea Colombiana, se presenta un trabajo de investigación de diseño mixto explorativo secuencial, donde se abordó las competencias contempladas por el Apéndice I del Documento 9995 de la OACI (2013) las cuales determinaron el punto de partida para la investigación, se establecen 10 competencias claves específicas para la formación de un piloto militar evaluadas y validadas por Oficiales, Directores de seguridad Operacional, Director de medicina aeroespacial y Pilotos de la FAC, incluyendo su descripción y sus comportamientos observables asociados, articulando la regulación emocional como proceso subyacente e indivisible al despliegue de las mismas y con la resiliencia como propósito final de su desarrollo, de modo que su articulación con el entrenamiento pueda generar un impacto directo sobre la disminución de eventos por factor humano y se afiance la seguridad operacional en la Fuerza Aérea Colombiana.
The Migration Dilemma of the Younger Generation from the Perspective of Wage Purchasing Power
Authors: Wypych Nataniel , Zawolska Zuzanna
Published: October 2023

The purpose of the article. The aim of the article is to determine whether there is a need to differentiate between countries in terms of the amount of aid they provide for the return of their citizens, and in which of the European countries a person can save the most and build up wealth in the fastest way.

Methodology. The study is based on historical data from 2016 to 2021 on average salaries, average cost of living, average price per square meter of housing in a country’s capital and the average price of a VW Golf IV car in 37 European countries.

Results of the research. In the general view of the study presented below, the countries to which economic migration can bring the most benefits are Switzerland, Luxembourg, and Denmark. On the other hand, countries that may not meet economic needs include North Macedonia, Moldova, Montenegro, and Albania. One can save the fastest per square meter of housing in Belgium, Iceland, and Switzerland. The fastest way for people to save money for a car is available in Switzerland, Luxembourg, and Great Britain.
Safeguarding Its Way to Security or Not – Should Fintech Become a Bank(Tech)?
Authors: Pawlak Kamila
Published: October 2023

The purpose of the article. This article explores the trend of fintech firms obtaining banking licenses, challenging their traditional advantage of not being banking institutions. It investigates two hypotheses:

H1 – Banking licenses bring more opportunities than threats for fintech companies;H2 – Obtaining licenses positively impacts their profitability.

Methodology. The study utilizes the literature review and applies Porter’s Five Forces methodology to assess the strategic implications of banking licenses for fintech firms. Financial analysis is conducted on three selected companies based on market capitalization, banking license timeline, and geographical diversification. Profitability ratios (ROE and ROA) are analyzed before and after obtaining the license.

Results of the research. Fintech firms with banking licenses experience more opportunities than threats, as confirmed by Porter’s analysis. However, only one out of three analysed companies immediately improved profitability ratios after obtaining the license. In conclusion, obtaining banking licenses opens growth opportunities for fintech firms, but immediate profitability improvements are not guaranteed. Additional requirements and challenges arise during the transition to a banking area. The study acknowledges limitations and suggests further research to confirm and expand these findings in the evolving fintech landscape.
L1 Gene based Molecular Characterization of Bovine Papillomavirus Type 1 (BPV1) Isolated from Cutaneous Warts of Cattle, Maharashtra
Authors: Tumlam, Uma M. , Desai, Dhruv. N. , Muglikar, Dushyant. M. , Pawade Mrunalini. M. , Mhase Prashant. P.
Published: October 2023

Background: Bovine papillomatosis (BP) is distributed worldwide among cattle but is relatively less common in buffaloes. Prevalence of this disease is established in buffaloes from India and Italy caused by bovine papilloma virus (BPV). The current study aimed to study the detection of bovine papilloma virus from cutaneous warts by polymerase chain reaction and confirmed by nucleotide sequencing and phylogenetic analysis. Methods: In this study a total of 10 wart samples from affected cattle were aseptically collected. Grossly, most of cutaneous warts were of variable sizes, rough or coarse in texture, grayish/blackish/flesh colored, irregular in shape (dome or button) or resembling cauliflower-like masses and elevated from skin surface by broad base. Molecular characterization of viral DNA from wart samples and partial gene sequencing, its analysis were carried out by using bioinformatics tools to establish the phylogenetic relationship. Result: In our investigation it revealed that out of total 10 cutaneous wart tissue samples, only six cattle were positive for BPV-1 while all the samples were found negative for BPV-2. The phylogenetic analysis of BPV-1gene of papilloma virus of cattle showed 100% homology with already reported sequence from china. The BPV-1 partial sequences generated in present study revealed close homology as well as with the earlier published BPV-1 sequences on NCBI.
Alleviating Impact of PEG Induced Drought Stress on Maize Seed Germination and Vigour with Effective Seed Priming Agents
Authors: Manavalagan Nivethitha , Velusamy Manonmani , Jerlin R. , Kalarani M.K. , Easwaran Kokiladevi
Published: October 2023

Background: Drought stress poses a significant challenge to agricultural productivity, particularly in regions with limited water availability. Maize, a staple crop worldwide, is highly susceptible to drought stress, leading to reduced seed germination, stunted growth and ultimately diminished yields. Addressing this issue, in this study various phytohormones and polyamines were used as priming agents for seeds to evaluate its performance to mitigate drought stress in maize seed germination and vigour. It plays crucial roles in regulating plant growth and development, as well as responses to various environmental stresses, including drought. These hormones modulate physiological and biochemical processes, leading to adaptive changes that helps maize plants to cope with water scarcity. Methods: The experiment was conducted by exposing maize seeds primed with different phytohormones and polyamines in optimum along with non primed seeds (control) to various levels of PEG concentration ranging from -0.2 MPa to -1.0 MPa for creating drought stress. Primed seeds subjected to a germination test. The seedling growth parameters and seed vigour were evaluated to analyse better performing seed priming treatment to mitigate drought stress. Result: From the experiment it is concluded that increase in concentration of PEG (from -0.2 Mpa to -1.0 MPa) decreased the seed germination and seed vigour traits in maize. Among seed priming treatments, seeds primed with melatonin 150 µM showed greater performance seedling vigour and its related traits even under water deficit stress condition. In conclusion, seed priming with melatonin exhibited superior efficacy in mitigating drought stress in maize. This finding highlights the potential of melatonin as a promising seed priming agent for enhancing drought tolerance in maize seeds. As seed priming is simple, easy and cost effective method, farmers can use this technology as one of their practice to eliminate the effect of drought stress in maize crop.
Predicting Potential Bankruptcy PT. Wismilak Inti Makmur, Tbk Using The Altman Z-Score Method
Authors: Maulana Wahyu , Andrianingsih Very
Published: October 2023

Indonesia is one of the countries that are still pro and contra towards cigarettes. Cigarettes are considered one of the dangerous products for public health and safety, but on the other hand the cigarette industry is the largest contributor to tax revenue in Indonesia. This study aims to determine the company's financial performance and to determine the potential for bankruptcy using the Altman z-score method at PT. Wismilak Inti Makmur Tbk. The type of research is descriptive quantitative while the population is all financial reports published by companies and the sample is financial statements for 2017-2021. Data collection techniques using the method of documentation. The data analysis technique used the modified Altman z-score method. Based on the results of the analysis and discussion of the modified altman z-score, it can be concluded that the company's financial condition for the 2017-2021 period is in good or healthy condition because the Z-score value is > 2.6. Even though in 2021 the z-score will decrease slightly, it is not at risk of going bankrupt. Suggestions for companies, in order to maintain financial performance every year in order to stay in good health
A Single-center Experience of Synchronous and Metachronous Hematologic and Oncologic Tumors
Authors: YAVAŞOĞLU Filiz , ÖZDEMİR Çiğdem , ŞENOL Yiğit , DEMİR Hacer , BAYKARA Meltem
Published: October 2023

The incidence of cancer is increasing in the world. With the developments in cancer treatment, the life expectancy of patients is prolonged and the incidence of secondary malignancies is increasing. We retrospetively patients with syncronous / metachronous oncological malignancies accompanying hematological malignancies in a newly established hematology center. Data were obtained from the medical records. Demographic data, treatments and overall survival of the patients were evaluated. Twenty eight (6%) of 433 patients hematological malignancies were included in the study. 12 patients (42.9) were diagnosed with syncronous and 16 (57.1%) patients with metachronous hematologic-oncologic tumors. Sixteen of the patients were male,twelve were female. In syncronous tumors, the most common hematologic malignancy was Non-hodgkın lymphoma (NHL), while the most common oncologic malignancies were thyroid papillary cancer and colon cancer. In metachronous tumors, the most common malignancies were NHL and breast cancer. The median time between diagnosis of metachronous tumors was 49.5 months (8-192 months). The median survival of patients with syncronous malignancies was 19 months (SE=12.19) (95% CI 0-42.89), with metachronous malignancies was 22 months (SE=14.0) (95% CI 0-49.44). There was no statistically significant difference in the comparison of survival curves of patients with syncronous and metachronous malignancies (p=0.382). Oncological malignancies accompanying hematological malignancies are not uncommon. There is no standart treatment for syncronous / metachronous hematologic malignancies. In the presence of syncronous multipl malignancies should be evaluated individually.
Evaluating e-Connect: Mitigating Race by Gender Disparities in Behavioral Health Referral Among Youths on Probation, Northeast United States, 2019
Authors: Ryan Margaret E. , Elkington Katherine S. , Sarapas Casey , Sichel Corianna , Taxman Faye , Dennis Michael L. , Wasserman Gail A.
Published: October 2023

Addressing the behavioral health needs of youths involved in the justice system is key to reducing recidivism risk and preventing long-term system involvement. However, rates of treatment referral and initiation remain low, especially among minoritized youths and boys. The e-Connect System, a digital, clinical decision support system, addresses this problem by increasing rates of behavioral health treatment referral and initiation rates among youths on probation. In this study, we examine whether e-Connect helps improve equity in referral and treatment initiation outcomes. (Am J Public Health. 2023;113(12):1267–1270. https://doi.org/10.2105/AJPH.2023.307417 )
Corpora electrónicos en la formación del traductor/intérprete: una propuesta didáctica para el desarrollo de la competencia traductora
Authors: Rodríguez Faneca Cristina
Published: October 2023

En este trabajo se presenta una propuesta didáctica para el desarrollo de la competencia instrumental del traductor en formación desde una perspectiva socioconstructivista a través del trabajo con corpus ad hoc. Estas unidades didácticas se encuentran insertas, a su vez, dentro de la programación de una asignatura de carácter instrumental y, por ello, la temporalización de la enseñanza, la programación y la evaluación formativa resultan primordiales. Además, se pretende que dichas unidades didácticas supongan un acercamiento realista al papel de los corpus ad hoc como herramienta de documentación en el contexto de la práctica profesional de la traducción, además de implicar la participación de los estudiantes de forma activa en el proceso de enseñanza-aprendizaje.
Diferencias y similitudes entre los sistemas de salud europeos: el caso de Alemania y España aplicado a la traducción jurada de textos médico-legales
Authors: Lemke Katrin Vanessa
Published: October 2023

No cabe duda de que la movilidad de las personas ha aumentado en las últimas décadas y, con ella, la necesidad de traducciones como las de textos médico-legales en el par de idiomas alemán-español. Para poder lograr una traducción de calidad, el traductor médico ha de conocer a fondo el ámbito en el que se mueve y, no solo el de la medicina en su sentido más estricto, sino también el sistema de salud al que el documento pertenece. Por este motivo, nos propusimos estudiar los sistemas de salud alemán y español en el contexto de la seguridad social y los modelos existentes, analizándolos y comparándolos, para determinar, finalmente, sus diferencias y similitudes, cuyo conocimiento servirá de apoyo al traductor médico alemán-español.
Entornos virtuales de aprendizaje en la adquisición de lenguas extranjeras: una aproximación bibliográfica aplicada a la enseñanza-aprendizaje del alemán, español, francés e inglés como L2
Authors: Intriago Cedeño Guillermo
Published: October 2023

El presente trabajo ofrece una revisión bibliográfica en torno a los estudios existentes sobre entornos virtuales de aprendizaje aplicados a la enseñanza y el aprendizaje del español como lengua extranjera (ELE), y el alemán, el francés y el inglés como segunda lengua o L2.
Unmanned aircraft systems and tracer dyes : potential for monitoring herbicide spray distribution
Authors: Mudge Christopher , Suir Glenn , Sperry Benjamin
Published: October 2023

Chemical control of nuisance aquatic vegetation has long been the most widely utilized management tool due to its high level of efficacy, limited environmental impacts, and relatively low cost. However, unprecise application of herbicides can lead to uncontrolled invasive plants and unintended management costs. Therefore, precision herbicide delivery techniques are being developed to improve invasive plant control and minimize impacts to non-target plants. These technological advancements have the potential to enhance aquatic ecosystem protection from invasive species while reducing associated management costs. Despite the benefits of using registered herbicides for aquatic plant control in efforts to restore aquatic habitats, their use is often misunderstood and opposed by public stakeholders. This can lead to significant challenges related to chemical control of nuisance aquatic vegetation. Thus, US Army Corps of Engineers (USACE) Districts seek improved methods to monitor and quantify the distribution (i.e., amount of herbicide retained on plant foliage compared to those deposited into the water column) of herbicides applied in aquatic systems. Monitoring herbicide movement in aquatic systems can be tedious and costly using standard analytical methods. However, since the inert fluorescent tracer dye Rhodamine WT (RWT) closely mimics product movement in the aquatic environment it has been used as a cost-effective surrogate for herbicides tracing. The use of RWT (or other inert tracer dyes) can be an efficient way to quantify herbicide retention and deposition following foliar treatments. However, the collection of operational spray deposition data in large populations of invasive floating and emergent plant stands is labor intensive and costly. One proposed solution is the use of remote sensing methods as an alternative to traditional in situ samples. Specifically, using unmanned aircraft systems (UAS) in conjunction with RWT could provide more efficient monitoring and quantification of herbicide spray distribution and in-water concentrations when using RWT in combination with herbicides. A better understanding of UAS capabilities and limitations is key as this technology is being explored for improved and integrated management of aquatic plants in the U.S. This technical note (TN) provides a review of literature to assess the state of knowledge and technologies that can assist USACE Districts and partners with tracking herbicide movement (using RWT as a surrogate or additive), which could improve operational monitoring, thus reducing the level of uncertainty related to chemical applications and non-target impacts, and thus improve management in aquatic systems.
Review of riparian models for assessing ecological impacts and benefits
Authors: Wiest Samantha , Hernandez-Abrams Darixa , McKay S.
Published: October 2023

Riparian zones are key transitional ecosystems between upland and aquatic zones, and these systems are often degraded due to both land use change and stream processes (e.g., deforestation and water impoundments and/or diversions). These important ecosystems require restoration because of the many benefits they provide ranging from providing habitat for diverse species to promoting water quality. Restoration practitioners, regulators, and researchers require riparian assessment methods and models to efficiently guide mitigation and restoration planning. This technical note (TN) compiles a subset of existing riparian tools and evaluates them relative to model objectives, modeling approach, and input variables. Findings are synthesized into a gap analysis of these models to inform future riparian model development and improve riparian assessment.
Beneficial use of dredged material : a workshop to explore engineered drainage soils for stormwater management
Authors: Theiling Charles , Lees Ray
Published: October 2023

Beneficial use of dredged material in engineered soils is an alternative to achieve environmental and economic sustainability for waterway operations. Engineered soils can combine navigation and environmental dredging with municipal and commercial waste streams to create a valuable commercial soil product while reducing public operating costs, creating economic opportunity, and creating better soil products for lower cost. The need, opportunities, and challenges to establishing an Illinois Waterway-based commercial soil industry were explored by river, highway, stormwater, environmental resource managers, and industry experts in a workshop in Peoria, IL, on 4–5 September 2019.
Sobre Silêncios e Naturalizações: Uma Análise Crítica do Discurso da Formulação do I Plano Nacional de Desenvolvimento (I PND) (1972-1974)
Authors: Rocha Machado Joao Guilherme , Pineda Andréa Martini
Published: October 2023

Objetivo da pesquisa: Interpretar os discursos presentes na formulação do I Plano Nacional de Desenvolvimento (I PND), a partir das escolhas linguísticas feitas pelo governo militar vigente à época.

Enquadramento teórico: A base teórica para o artigo está ancorada na Virada Argumentativa e na Análise do Discurso.

Metodologia: É realizada uma triangulação entre a Análise do Discurso Francesa e a Análise Crítica do Discurso, nas perspectivas de Michel Pêcheux e Norman Fairclough, respectivamente, para examinar o I PND.

Resultados: O Plano buscou construir o ideário de um “modelo brasileiro de desenvolvimento”, que beneficiaria de forma equilibrada toda a população brasileira. Identificamos a presença de silêncios (não-ditos) no texto do I PND como o contexto não democrático que o Brasil vivia, a não participação dos cidadãos como sujeitos ativos do desenvolvimento nacional e a escolha linguística por vocábulos como Revolução, democracia e índole brasileira. A partir da Formação Ideológica-Discursiva (FID) presente à época, o discurso do I PND reproduziu a dominação da grande burguesia nacional sobre os trabalhadores e do regime militar sobre os grupos opositores, por meio de um texto ideologicamente construído. Ao apresentar-se de forma “naturalizada” como o único modelo brasileiro de desenvolvimento, silencia os rastros do processo de dominação.

Originalidade: O I PND costuma ser analisado sob uma perspectiva de Economia. O presente artigo buscou um novo olhar, partindo do campo de políticas públicas, ancorado na Virada Argumentativa e na Análise do Discurso para examinar o Plano, com o mesmo rigor e validade acadêmica.

Contribuições teóricas e práticas:  A principal contribuição do trabalho é mostrar como um plano de desenvolvimento econômico, costumeiramente apresentado como técnico e neutro, é atravessado por aspectos discursivos. A Virada Argumentativa, e mais especificamente a Análise do Discurso - usualmente utilizados para analisar políticas sociais – aqui são utilizadas para examinar políticas públicas econômicas.
Divisionalização na Administração Pública e seus Reflexos na Institucionalização de um Sistema de Informação Gerencial Financeiro
Authors: Leal Guimarães Duanne Emanuel , Da Silva de Oliveira Raimunda Macilena , Figueira Marquezan Luiz Henrique , Pimentel Gonzaga Rosimeire
Published: October 2023

Resumo:

Objetivo da pesquisa: Analisar como a estrutura divisionalizada de uma Autarquia Pública Federal motiva ou inibe a institucionalização de um Sistema de Informação Gerencial Financeiro (SIGF), sob o enfoque da New Institutional Sociology (NIS).

Enquadramento teórico: A Teoria Institucional, analisada sob perspectiva da New Institutional Sociology – NIS, incorporou o modelo de Tolbert e Zucker (2006) como lente de análise dos fatores motivadores e inibidores da institucionalização do SIGF.

Metodologia: A pesquisa caracteriza-se como descritiva, com abordagem qualitativa, e foi realizada por meio de estudo de caso.

Resultados: A estrutura divisional foi compreendida como um dos aspectos internos que motivaram a fase da habitualização do SIGF, pela necessidade de padronização, de modo a facilitar a aferição do desempenho dessas unidades. No Estágio da Semi-institucionalização, os resultados indicaram que as características das unidades e gestores divisionais atuaram ora como motivadora e ora inibidora da institucionalização. No Estágio da Total institucionalização, não se percebeu influência das características da estrutura divisionalizada, senão aquela indireta e derivada das fases da habitualização e objetificação, que permitiu ao SIGF avançar na fase de sedimentação.

Originalidade: Há uma compreensão incipiente da institucionalização de SIG em certos ambientes institucionais. Pesquisas anteriores voltadas ao setor público não analisaram a interlocução entre divisionalização e institucionalização de SIG.

Contribuições teóricas e práticas: Os resultados podem contribuir com a literatura no sentido de apresentar como um ambiente divisionalizado se reflete na institucionalização de SIG no setor público. Identificar potenciais elementos que motivam ou inibem a institucionalização de um SIG no contexto de unidades divisionais podem resultar em SIG projetados adequadamente a essa realidade, que contribuem para uma maior racionalização dos recursos públicos, e favorecem a otimização dos benefícios propostos pelo sistema, haja vista o reforço de sua utilidade para o alcance dos objetivos institucionais.

Palavras-chave: Institucionalização, Divisionalização, Fatores Motivadores e Inibidores.
Forensic significance of intracardiac expressions of Nrf2 in acute myocardial ischemia
Authors: Hiyamizu Shion , Ishida Yuko , Yasuda Haruki , Kuninaka Yumi , Nosaka Mizuho , Ishigami Akiko , Shimada Emi , Kimura Akihiko , Yamamoto Hiroki , Osako Miyu , Zhang Wei , Goto Utako , Kamata Ten , Kondo Toshikazu
Published: October 2023

When exposed to oxidative and electrophilic stresses, a protective antioxidant response initiates through nuclear factor erythroid 2-related factor 2 (Nrf2). Nonetheless, the extent of its importance in the forensic diagnosis of acute ischemic heart diseases (AIHD), such as myocardial infarction (MI), remains uncertain. On the other hand, immunohistochemical analyses of fibronectin (FN) and the terminal complement complex (C5b-9) prove valuable in identifying myocardial ischemia that precedes necrosis during the postmortem diagnosis of sudden cardiac death. In this study, we investigated the immunohistochemical levels of Nrf2, FN, and C5b-9 in human cardiac samples to explore their forensic relevance in the identification of acute cardiac ischemia. The heart samples were obtained from 25 AIHD cases and 39 non-AIHD cases as controls. Nrf2 showed the localization in the nuclei of cardiomyocytes while FN and C5b-9 were detected in the myocardial cytoplasm. The number of intranuclear Nrf2 positive signals in cardiomyocytes increased in AIHD cases compared to control cases. In addition, grading of positive portions for cardiac FN and C5b-9 in myocardium was also significantly enhanced in AIHD, compared to controls. Collectively, these results indicate that immunohistochemical investigation of Nrf2 combined with FN, and/or C5b-9 holds potential for identifying early-stage myocardial ischemic lesions in cases of sudden cardiac death.
Retention strategies are routinely communicated to potential trial participants but often differ from what was planned in the trial protocol; an analysis of patient information leaflets and their corresponding protocols.
Authors: Murphy Ellen , Gillies Katie , Shiely Frances
Published: October 2023

Background
Retaining participants in randomised controlled trials (RCTs) is challenging and trial teams are often required to use strategies to ensure retention or improve it. Other than monetary incentives, there is no requirement to disclose the use of retention strategies to the participant. Additionally, not all retention strategies are planned at the design stage of a trial, but some protocols include plans to use strategies to promote participant retention. It is yet unknown if these plans are communicated in the corresponding PILs. The purpose of our study was to determine if Patient Information Leaflets (PILs) communicate plans to promote participant retention and if so, are these outlined in the corresponding trial protocol.
Methods
157 PILs and their 121 corresponding protocols from Clinical Trial Units (CTUs) in the UK were analysed. Directed (deductive) qualitative content analysis was used to analyse the participant retention text from the PILs. Data were presented using a narrative summary and frequencies where appropriate.
Results
Plans to promote participant retention were communicated in 81.5% (n = 75) of PILs. Fifty-six percent (n = 42) of PILs communicated plans to use ‘combined strategies’ to promote participant retention. The most common individual retention strategy was telling the participants that data collection for the trial would be scheduled during routine care visits (16%; n = 12 PILs). The importance of retention and the impact that missing, or deleted, data has on the trial were explained in 6.5% (n = 6) and 5.4% (n = 5) of PILs respectively. Out of the 59 PILs and 58 matching protocols that communicated plans to use strategies to promote participant retention, 18.6% (n = 11) communicated the same information, the remaining 81.4% (n = 48) of PILs either only partially communicated the same information or did not communicate the same information.
Conclusion
Retention strategies are frequently communicated to potential trial participants in PILs however the information provided often differs from the content in the corresponding protocol. Participant retention considerations are best done at the design phase of the trial and we encourage trial teams to be consistent in the communication of these strategies in both the protocol and PIL.
Effect Of Ambient Lead on Progesterone and Pregnancy-Associated Glycoprotein 1 And Their Relationship To Abortion In Zaraibi Goats: A Field Study
Authors: Harb Gamal M. , Mosaad Abrar F. , El-Nakhla Sayed M. , El-Rasoul Ferial H. Abd , El-Din Ahmed M. Shehab , Ali Atef A. , Harb Gamal M.
Published: October 2023

This study aimed to investigate the impact of ambient lead (Pb) exposure on progesterone (P4) and pregnancy-associated glycoprotein 1 (PAG1) and their relationship with abortion in Egyptian Zaraibi goats, C. hircus. To achieve this, 40 female goats (does) were mated with highly fertile male goats, resulting in a total of 28 pregnant goats. Eight of them aborted, and each of the 12 pregnant goats gave birth to one kid, whereas the remaining eight gave birth to twins. The current data demonstrated that the levels of blood Pb in aborted goats were significantly higher than those in non-aborted goats at all pregnancy stages, and this was followed by significant decreases in serum PAG1 and P4. Furthermore, there were substantial inverse associations between blood Pb concentration and levels of PAG1 and P4, with markedly negative correlation coefficients of -0.88 and − 0.77, respectively, in aborted goats. The threshold level (cut-off point) of Pb required to cause abortion was ≥ 32.08 µg/dl, but for PAG1 and P4 were respectively ≤ 0.95 ng/ml and ≤ 0.48 ng/ml. Additionally, cut-off levels of ≥12.34 ng/ml and ≥ 31.52 ng/ml for P4 and PAG1, respectively, were needed to deliver twins. In conclusion, pollution-induced increases in Pb bioavailability resulted in dramatic decreases in P4 and PAG1 levels, leading to abortions. PAG1 and P4 levels are also key factors in determining whether Zaraibi goats will give birth to twins.
A Stepped Wedge Cluster Randomized Trial to evaluate the effectiveness of a Community leader-driven kit-based Diabetes-Self-Management-Education approach in improving diabetes control and care: A study protocol for The DElhi Diabetes INTervention Trial (DEDINTT)
Authors: Nagpal Jitender , Rawat Swapnil , Gupta Lovely , Negi Avantika , Oraon Divya Shashi
Published: October 2023

Introduction:
Diabetes self-management education (DSME) helps patients self-manage their condition and improve outcomes/quality of life. However, access to DSME is limited, particularly in low-income areas. This study aims to develop a DSME training kit (EK-DIN), understand barriers to implementation and evaluate the effectiveness and sustainability of Community Leader (CL) based rollout using a stepped wedge cluster randomised trial format.
Methods and Analysis:
The mixed methods study will begin with a qualitative study to evaluate the facilitators and barriers towards CL-based DSME. The in-depth interview notes will be transcribed for thematic analysis. These results will be utilized for a stakeholder’s workshop to develop the EK-DIN kit, a patient-interfacing app, and an implementation plan. Roll-out will be conducted in 30 clusters in Delhi preselected by the DEDICOM-II survey in 5 steps (6 clusters every three months:2 each from each socio-economic category; randomly selected per sequence). A CL from each cluster will be trained in using the EK-DIN kit /app over one month. The trained CL will conduct DSME sessions amongst the cluster residents using the EK-DIN kits provided fortnightly for three months. Compliance and blood parameters data will be collected at baseline, three months after the intervention and every quarter thereafter till completion. Change in HbA1c before and after the intervention will be evaluated as the primary outcome using the swCRTdesign package for R version 4.0.2 and the swSummary function. The sustainability of the effects will be evaluated using the change in quarterly parameters after intervention completion.
Discussion:
A positive result will set the template for a generalisable public health intervention with proven community effectiveness, sustainability, cost-effectiveness and positive quality of life impact. While a negative result will require the testing of alternative approaches it would still add substantially to existing knowledge on the subject. Given the diverse socio-cultural setting in which the trial is being proposed and the high power of the study, the results (positive or negative) should be widely applicable and have policy implications.
Trial Registration Number:CTRI/2023/07/054963
Remediation of brewery wastewater and reuse for β-glucans production by basidiomycete fungi
Authors: Timm Thaynã Gonçalves , Schipmann Djonice Beatriz Doege , Costa Tania Maria , Tavares Lorena Benathar Ballod
Published: October 2023

Purpose
This paper aims to assess the potential of basidiomycete fungi to mycoremediate brewery wastewater and generate a bioactive molecule (β-glucan) for industrial applications.
Methods
Six basidiomycete fungi, Ganoderma applanatum, Ganoderma lipsiense, Pleurotus ostreatus, Pycnoporus sanguineus, Lentinula edodes, and Oudemansiela canarii were grown in submerged fermentation using brewery wastewater (BW). β-glucan production, biomass concentration, reducing sugar content, and pH were evaluated and the fungus with the highest β-glucan production was subjected to a kinetic study of β-glucan production.
Results
Results showed that BW has important nutrients for fungi growth and all species had high biomass production. The highest production of β-glucans was for G. lipsiense (23.87%) and its kinetic study showed the highest production of β-glucans at 14 days and the greatest increase in biomass at 21 days. There was a correlation between the production of β-glucans and the consumption of BW substrate and a decrease in chemical oxygen demand (81% at 21 days), nitrate (<3.00 mg L-1), total phosphorus (66.326 mg L-1), and total dissolved solids (634.1 mg L-1).
Conclusion
This study highlighted a sustainable use of BW for its remediation besides fungal biomass production as a source of a high-value product for the biotechnology industry, opening prospects in the circular bioeconomy.
Two conserved transcription factors and a histone deubiquitinase regulate the mitochondrial unfolded protein response and longevity interacting with insulin signalling.
Authors: Artal-Sanz Marta , Fernandez-Abascal Jesús , Hernando-Rodríguez Blanca , Rodríguez-Palero María Jesús , Cabanillas Aitor Jarit , Martínez-Bueno David , Pérez-Jiménez Mercedes , Clavijo-Bernal Enrique , Cambón Aitana , Cases Ildefonso
Published: October 2023

Ageing is characterized by physiological decline and increased risk of agerelated diseases. The mitochondrial prohibitin (PHB) complex, a ringlike structure in the inner mitochondrial membrane, is critical to mitochondrial function and proteostasis. Depletion of PHB has opposite effects on ageing, shortening lifespan in wildtype worms while extending the lifespan of different metabolically compromised animals, including that of insulin/IGF-1like signalling (IIS) receptor mutants daf-2(e1370). Lack of PHB strongly induces the mitochondrial unfolded protein response (UPRmt) to maintain mitochondrial proteostasis, while daf-2 mutants attenuate the UPRmt triggered by PHB depletion. In this study, we aimed at identifying new pathways involved in the regulation of the PHBmediated mitochondrial stress response, as well as mechanisms responsible for the opposite longevity outcomes of PHB depletion. Towards this aim, we carried out a genomewide double RNAi screen, depleting C. elegans genes having a human orthologue, in PHBdepleted otherwise wild-type animals and PHBdepleted IIS mutants. We uncovered both known and new PHB genetic interactors affecting the UPRmt in the different genetic backgrounds. We identified two new transcription factors ZNF-622 and TLF-1 as specific regulators of the mitochondrial stress response. We further established chromatin remodelling via the histone deubiquitination protein USP-48 as a strong differential modulator of the mitochondrial stress response and ageing in wild-type and IIS mutants. Furthermore, we suggest USP-48 as a regulator of gene expression upon mitochondrial stress and defective IIS signalling as its nuclear expression is elevated in such conditions. Finally, we observe that the UPRmt induction by lack of USP-48 is largely independent of ATFS-1 and fully independent of DVE-1, the canonical UPRmt transcription factors. Interestingly, lack of USP-48 increases nuclear DVE-1 levels, while DVE-1 depletion further increases the UPRmt in usp-48 mutants. Overall, this study identifies new players specifically involved in the regulation of the mitochondrial stress response and longevity and sheds light on the processes contributing to the differential effect in ageing of PHB depletion in wild-type and metabolically compromised animals.
Demystifying the phase diagrams of deep eutectic solvents within an extensive chemical space
Authors: Fajar Adroit T.N. , Hanada Takafumi , Hartono Aditya D. , Goto Masahiro
Published: October 2023

Assessing the formation of a deep eutectic solvent (DES) necessitates a solid-liquid equilibrium (SLE) phase diagram. Yet, many studies focusing on DES applications do not include this diagram because of challenges in measurement, leading to misidentified eutectic points. The present study provides a practical approach for estimating the SLE phase diagram of any binary mixture from the structural information, utilizing machine learning and quantum chemical techniques. By pinpointing the eutectic point coordinates within an extensive chemical space, we highlighted the impact of the mole fractions and melting properties on the eutectic temperatures. Our results also showed the potential for misclassifying ideal eutectic mixtures, and even regular solutions, as DESs if one solely observes liquefaction phenomena. Molecular dynamics simulations of selected mixtures at the eutectic points emphasized the pivotal role of hydrogen bonds in dictating mixture behavior. This approach promises to streamline DES design by isolating potential search areas.
Inexpensive Volcanic Ash Catalyst for Pyrolysis of Plastic Waste into Fuel Using Sequential Thermo-Catalytic Reactor
Authors: Suhartono Suhartono , Romli Ate , Prabowo Bambang Hari , Saputra Dede Irawan , Zulfakri Zulfakri , Suharto Suharto , Achmad Feerzet , Hendriyana Hendriyana , Nurdini Lulu
Published: October 2023

Single-stage thermal pyrolysis of plastic waste produces liquid fuel (LF) of low quality and quantity and requires high temperature and long complete pyrolysis time. Pyrolysis of plastic waste via thermal and catalytic route using an existing sequential pyrolysis reactor and catalytic reformer was addressed to overcome this issue. Each low density polyethylene (LDPE) and polystyrene (Styrofoam) waste was converted plastic waste into LF at intervals of 200–400 oC and a pyrolysis time of 30–90 minutes. Low-cost and type of catalyst, such as volcanic ash was divined as important roles in the characteristics and quantity of LF produced. The volcanic ash is revisited to find a better and more effective catalyst in converting plastic waste into LF due to it contains quite high SiO2 and Al2O3. The volcanic ash was activated physically and chemically. The catalyst characteristics were observed based on Brunauer-Emmet-Teller (BET) and Scanning Electron Microscopy–Energy Dispersion Spectroscopy (SEM-EDS) analysis. The properties and influence of using this catalyst in a reformer for second-stage degradation of plastic waste were observed. The characteristics of LF were observed by flash point, smoke point, ignition point, density, viscosity, calorific value, and GC-MS analysis. The results of the BET analysis of activated volcanic ash and inactivated volcanic ash showed a surface area of 3.8475 m2/g and 1.1188 m2/g, respectively. The results of SEM-EDS analysis depicted that the content of SiO2 and Al2O3 in volcanic ash was quite high of 81.89% and 5.57%, respectively with a better adsorption rate than inactive volcanic ash. The most dominant LF composition of styrofoam and LDPE is C8H8 (70.323%) and C10H20 (25.831%), respectively. LF fraction of LDPE pyrolysis has the largest composition in the range of C9–C14 carbon atoms of 61.27% as a high aliphatic proportion. Whereas the LF fraction from styrofoam pyrolysis has the largest composition in the range of C5–C9 carbon atoms of 92.49% with a low percentage of aliphatic hydrocarbons alkanes (paraffin) and alkenes (olefin). Based on the results characteristics and GC-MS analysis, the LF of LDPE pyrolysis is the closest hydrocarbon composition to kerosene, whereas the LF fraction from styrofoam is on par with gasoline fuel, with higher quality compared to commercial gasoline.
Sensitivity analysis for Sisko nanofluid flow through stretching surface using response surface methodology
Authors: Upreti Himanshu , Uddin Ziya , Pandey Alok Kumar , Joshi Navneet
Published: October 2023

In this research the influences of quadratic Boussinesq approximation and quadratic thermal radiation on heat transfer analysis of magnetized Sisko nanofluid flow with Cattaneo-Christov (CC) heat flux through stretching surface was studied using response surface methodology (RSM). The upshots of the transformed differential equations is attained by bvp4c method. The heat transfer and skin friction calculations are done for acting parameters i.e., magnetic field, Eckert number, Forchheimer parameter, thermal relaxation parameter, radiation parameter, porosity parameter, and Biot number. For sensitivity analysis, the response surface method with FCC design is utilized. From the outcomes, it was concluded that the friction coefficient and Nusselt number have positive sensitivities for Forchheimer parameter. Moreover, heat transfer rate is declined with increase in magnetic field, Biot number and thermal relaxation parameter values for the conditions shear thickening (n<1) and shear thinning (n<1) .