bluuebunny/crossref_metadata_2025 huggingface dataset:
Data from A Phase I/II Trial of HER2 Vaccine–Primed Autologous T-Cell Infusions in Patients with Treatment Refractory HER2–Overexpressing Breast Cancer
Authors: Disis Mary L. , Dang Yushe , Coveler Andrew L. , Childs Jennifer S. , Higgins Doreen M. , Liu Ying , Zhou Jing , Mackay Sean , Salazar Lupe G.
Published: September 2023

AbstractPurpose:
High levels of type I T cells are needed for tumor eradication. We evaluated whether the HER2-specific vaccine–primed T cells are readily expanded ex vivo to achieve levels needed for therapeutic infusion.
Patients and Methods:
Phase I/II nonrandomized trial of escalating doses of ex vivo–expanded HER2-specific T cells after in vivo priming with a multiple peptide–based HER2 intracellular domain (ICD) vaccine. Vaccines were given weekly for a total of three immunizations. Two weeks after the third vaccine, patients underwent leukapheresis for T-cell expansion, then received three escalating cell doses over 7- to 10-day intervals. Booster vaccines were administered after the T-cell infusions. The primary objective was safety. The secondary objectives included extent and persistence of HER2-specific T cells, development of epitope spreading, and clinical response. Patients received a CT scan prior to enrollment and 1 month after the last T-cell infusion.
Results:
Nineteen patients received T-cell infusions. Treatment was well tolerated. One month after the last T-cell infusion, 82% of patients had significantly augmented T cells to at least one of the immunizing epitopes and 81% of patients demonstrated enhanced intramolecular epitope spreading compared with baseline (P < 0.05). There were no complete responses, one partial response (6%), and eight patients with stable disease (47%), for a disease control rate of 53%. The median survival for those with progressive disease was 20.5 months and for responders (PR+SD) was 45.0 months.
Conclusions:
Adoptive transfer of HER2 vaccine–primed T cells was feasible, was associated with minimal toxicity, and resulted in an increased overall survival in responding patients.

See related commentary by Crosby et al., p. 3256
Data from A Bifunctional PARP-HDAC Inhibitor with Activity in Ewing Sarcoma
Authors: Ramos Louise , Truong Sarah , Zhai Beibei , Joshi Jay , Ghaidi Fariba , Lizardo Michael M. , Shyp Taras , Kung Sonia H.Y. , Rezakhanlou Alireza M. , Oo Htoo Zarni , Adomat Hans , Le Bihan Stephane , Collins Colin , Bacha Jeffrey , Brown Dennis , Langlands John , Shen Wang , Lallous Nada , Sorensen Poul H. , Daugaard Mads
Published: September 2023

AbstractPurpose:
Histone deacetylase (HDAC) inhibition has been shown to induce pharmacologic “BRCAness” in cancer cells with proficient DNA repair activity. This provides a rationale for exploring combination treatments with HDAC and PARP inhibition in cancer types that are insensitive to single-agent PARP inhibitors (PARPi). Here, we report the concept and characterization of a novel bifunctional PARPi (kt-3283) with dual activity toward PARP1/2 and HDAC enzymes in Ewing sarcoma cells.
Experimental Design:
Inhibition of PARP1/2 and HDAC was measured using PARP1/2, HDAC activity, and PAR formation assays. Cytotoxicity was assessed by IncuCyte live cell imaging, CellTiter-Glo, and spheroid assays. Cell-cycle profiles were determined using propidium iodide staining and flow cytometry. DNA damage was examined by γH2AX expression and comet assay. Inhibition of metastatic potential by kt-3283 was evaluated via ex vivo pulmonary metastasis assay (PuMA).
Results:
Compared with FDA-approved PARP (olaparib) and HDAC (vorinostat) inhibitors, kt-3283 displayed enhanced cytotoxicity in Ewing sarcoma models. The kt-3283-induced cytotoxicity was associated with strong S and G2–M cell-cycle arrest in nanomolar concentration range and elevated DNA damage as assessed by γH2AX tracking and comet assays. In three-dimensional spheroid models of Ewing sarcoma, kt-3283 showed efficacy in lower concentrations than olaparib and vorinostat, and kt-3283 inhibited colonization of Ewing sarcoma cells in the ex vivo PuMA model.
Conclusions:
Our data demonstrate the preclinical justification for studying the benefit of dual PARP and HDAC inhibition in the treatment of Ewing sarcoma in a clinical trial and provides proof-of-concept for a bifunctional single-molecule therapeutic strategy.
Druggable Targets in Cytokine Release Syndromes
Authors: Luri-Rey Carlos , Eguren-Santamaria Iñaki , Matos Ignacio , Berraondo Pedro , Melero Ignacio
Published: September 2023

Bispecific T-cell engagers and chimeric antigen receptor T cells share the problem of eliciting acute systemic inflammation episodes known as cytokine release syndrome. Knowledge on the sequential waves of cytokines that can be neutralized with clinically available agents is crucial to prevent or treat this condition without jeopardizing the antitumor therapeutic outcome.

See related article by Leclercq-Cohen et al., p. 4449
Figure S1 from Fibronectin Contributes to a BRAF Inhibitor–driven Invasive Phenotype in Thyroid Cancer through EGR1, Which Can Be Blocked by Inhibition of ERK1/2
Authors: Hicks Hannah M. , Pozdeyev Nikita , Sams Sharon B. , Pugazhenthi Umarani , Bales Elise S. , Hofmann Marie-Claude , McKenna Logan R. , Schweppe Rebecca E.
Published: September 2023

Figure S1. BRAF-V600E-mutated thyroid cancer cells lines exhibit varying levels of migration and baseline invasiveness.
Data from HTLV-1 bZIP Factor-Induced Reprogramming of Lactate Metabolism and Epigenetic Status Promote Leukemic Cell Expansion
Authors: Toyoda Kosuke , Yasunaga Jun-ichirou , Shichijo Takafumi , Arima Yuichiro , Tsujita Kenichi , Tanaka Azusa , Salah Tarig , Zhang Wenyi , Hussein Osama , Sonoda Miyu , Watanabe Miho , Kurita Daisuke , Nakashima Kazutaka , Yamada Kyohei , Miyoshi Hiroaki , Ohshima Koichi , Matsuoka Masao
Published: September 2023

Abstract
Acceleration of glycolysis is a common trait of cancer. A key metabolite, lactate, is typically secreted from cancer cells because its accumulation is toxic. Here, we report that a viral oncogene, HTLV-1 bZIP factor (HBZ), bimodally upregulates TAp73 to promote lactate excretion from adult T-cell leukemia-lymphoma (ATL) cells. HBZ protein binds to EZH2 and reduces its occupancy of the TAp73 promoter. Meanwhile, HBZ RNA activates TAp73 transcription via the BATF3-IRF4 machinery. TAp73 upregulates the lactate transporters MCT1 and MCT4. Inactivation of TAp73 leads to intracellular accumulation of lactate, inducing cell death in ATL cells. Furthermore, TAp73 knockout diminishes the development of inflammation in HBZ-transgenic mice. An MCT1/4 inhibitor, syrosingopine, decreases the growth of ATL cells in vitro and in vivo. MCT1/4 expression is positively correlated with TAp73 in many cancers, and MCT1/4 upregulation is associated with dismal prognosis. Activation of the TAp73–MCT1/4 pathway could be a common mechanism contributing to cancer metabolism.
Significance:
An antisense gene encoded in HTLV-1, HBZ, reprograms lactate metabolism and epigenetic modification by inducing TAp73 in virus-positive leukemic cells. A positive correlation between TAp73 and its target genes is also observed in many other cancer cells, suggesting that this is a common mechanism for cellular oncogenesis.

This article is featured in Selected Articles from This Issue, p. 337
Data from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Authors: Chen Lanpeng , Pronk Eline , van Dijk Claire , Bian Yujie , Feyen Jacqueline , van Tienhoven Tim , Yildirim Meltem , Pisterzi Paola , De Jong Madelon M E. , Bastidas Alejandro , Hoogenboezem Remco M. , Wevers Chiel , Bindels Eric M. , Löwenberg Bob , Cupedo Tom , Sanders Mathijs A. , Raaijmakers Marc HGP.
Published: September 2023

Abstract
Cancer initiation is orchestrated by interplay between tumor-initiating cells and their stromal/immune environment. Here, by adapted single-cell RNA sequencing, we decipher the predicted signaling between tissue-resident hematopoietic stem/progenitor cells (HSPCs) and their neoplastic counterparts with their native niches in the human bone marrow. LEPR+ stromal cells are identified as central regulators of hematopoiesis through predicted interactions with all cells in the marrow. Inflammatory niche remodeling and the resulting deprivation of critical HSPC regulatory factors is predicted to repress high-output HSC subsets in NPM1-mutated AML, with relative resistance of clonal cells. Stromal gene signatures reflective of niche remodeling are associated with reduced relapse rates and favorable outcome after chemotherapy across all genetic risk categories. Elucidation of the intercellular signaling defining human AML, thus predicts that inflammatory remodeling of stem cell niches drives tissue repression and clonal selection, but may pose a vulnerability for relapse-initiating cells in the context of chemotherapeutic treatment.
Utilização da distração óssea no tratamento de pacientes com Sequência de Pierre Robin
Authors: Santos Igor Bustamante Ferreira dos , Machado Ingrid Aquino , Barros Lorena de Oliveira , Souza Ana Cristina Rodrigues Antunes de
Published: September 2023

Introdução: A sequência de Pierre Robin é uma tríade de anomalias caracterizada por micrognatia, glossoptose e fissura palatina. Estão descritas na literatura algumas modalidades de tratamento para melhorar a qualidade de vida dos  pacientes com esta síndrome, como a distração óssea. Objetivo: Este artigo científico objetivou demonstrar a possibilidade de utilização da distração óssea na correção das anomalias advindas desta alteração. Materiais e métodos: Realizou-se uma busca de artigos em bases de dados eletrônicos e foram selecionados artigos escritos nos idiomas inglês e português, cujos temas abordados iam de encontro com o proposto por este trabalho e auxiliavam em sua produção. Resultados: Indivíduos com a Sequência de Pierre Robin apresentam características funcionais e estéticas comprometidas, afetando, consequentemente, as suas qualidades de vida. Conclusão: Concluiu-se que para uma reabilitação e um tratamento adequado, a técnica da distração óssea se mostrou muito eficaz. Cabe ressaltar a necessidade essencial de uma equipe multidisciplinar em atuação.
Antimicrobial photodynamic and photobiomodulation adjuvant therapies for medication-related osteonecrosis of the jaw – Report of two cases with long-term follow-up
Authors: Paiva Angela B. P. , Pereira Beatriz C. , Brozoski Mariana A. , Araújo Julia G. L. , Deboni Maria Cristina Zindel
Published: September 2023

Medication-related osteonecrosis of the jaw (MRONJ) is a relatively rare condition with high morbidity. In this study, we report the management of two recalcitrant cases of MRONJ in the mandibles of two older women who received treatment with alendronate for osteoporosis. Sequestrectomies, combined with antimicrobial photodynamic therapy (aPDT) and photobiomodulation (PBMT), were performed in both patients. During perioperative and weekly postoperative aPDT sessions, a diode laser treated three anatomical points by emitting a continuous gallium-aluminum-arsenide wave at 660 nm (red laser), 0.028 cm2, 0.1 W, 3.57 W/cm2 for 90 s per point, 9 J per point, 321 J/cm2, and a total energy of 27 J. PBMT was applied weekly after surgery at 808 nm wavelength (other parameters being equal) for wound healing and pain relief. Both patients were followed-up for two years without any report of recurrence. Thus, aPDT and PBMT can be considered non-invasive adjuvant therapies for MRONJ without any adverse effects.
“At Sea, At Odds, Astray, Adrift” : Linguistic Destabilization in Jhumpa Lahiri’s Self-Translated Novel Whereabouts
Authors: Wanner Adrian
Published: September 2023

This article compares the Italian original of Jhumpa Lahiri’s novel Dove mi trovo (2018) with the English self-translation, which was published in 2021 under the title Whereabouts. Lahiri claims that her embrace of Italian was a means to escape the alienation caused by her bilingual upbringing in Bengali and English. Paradoxically, this quest for wholeness was coupled with insecurity in Italian, a language in which Lahiri only achieved fluency in middle age. Self-translation puts this linguistic ambiguity to a new stress test. In the confrontation between Lahiri’s Italian-language and Anglophone selves, her English becomes affected by Italian calques, creating a hybridized language mirroring the author’s own hybrid linguistic consciousness.
Range extension of Marchantia formosana (Marchantiaceae, Marchantiophyta), with an updated key to Marchantiaceae taxa in East Asia
Authors: ZHENG TIAN-XIONG , LONG DAVID G. , SHIMAMURA MASAKI
Published: September 2023

Marchantia formosana is newly reported from Yunnan, China. An updated key to the East Asian taxa of the family Marchantiaceae is also provided.
Seasonal Variability of Near-Inertial/Semidiurnal Fluctuations and Turbulence in the Subarctic North Atlantic
Authors: Kunze Eric , Lien Ren-Chieh , Whalen Caitlin B. , Girton James B. , Ma Barry , Buijsman Maarten C.
Published: September 2023

Six profiling floats measured water-mass properties (T, S), horizontal velocities (u, υ), and microstructure thermal-variance dissipation rates χT in the upper ∼1 km of the Iceland and Irminger Basins in the eastern subpolar North Atlantic from June 2019 to April 2021. The floats drifted into slope boundary currents to travel counterclockwise around the basins. Pairs of velocity profiles half an inertial period apart were collected every 7–14 days. These half-inertial-period pairs are separated into subinertial eddy (sum) and inertial/semidiurnal (difference) motions. Eddy flow speeds are ∼O(0.1) m s−1 in the upper 400 m, diminishing to ∼O(0.01) m s−1 by ∼800-m depth. In late summer through early spring, near-inertial motions are energized in the surface layer and permanent pycnocline to at least 800-m depth almost simultaneously (within the 14-day temporal resolution), suggesting rapid transformation of large-horizontal-scale surface-layer inertial oscillations into near-inertial internal waves with high vertical group velocities through interactions with eddy vorticity gradients (effective β). During the same period, internal-wave vertical shear variance was 2–5 times canonical midlatitude magnitudes and dominantly clockwise-with-depth (downward energy propagation). In late spring and early summer, shear levels are comparable to canonical midlatitude values and dominantly counterclockwise-with-depth (upward energy propagation), particularly over major topographic ridges. Turbulent diapycnal diffusivities K ∼ O(10−4) m2 s−1 are an order of magnitude larger than canonical midlatitude values. Depth-averaged (10–1000 m) diffusivities exhibit factor-of-3 month-by-month variability with minima in early August.
Collective Action Infrastructure: The Downstream Effects of Urban Neighborhood Organizing
Authors: Chriswell Kaitlyn , Huberts Alyssa
Published: September 2023

What explains variation in neighborhood problem-solving? We argue that collective action infrastructure—place-based connections, organizations, knowledge, and practices formed while organizing—can reduce the costs of local collective action, even in communities without preexisting social and civic organizations. We adapt theories from the social movements literature about mobilizing structures and personal networks to the neighborhood context and propose that, even absent preexisting structures, an initial act of organizing in the face of a salient problem can itself facilitate future organizing. In contrast to expectations that local organizations will disband quickly upon achieving their initial goal, we argue that, because neighborhood problem-solving involves fixed costs and overlapping constituencies, local organizing infrastructure is often repurposable across issue areas. Observational data, a natural experiment, and a survey experiment from an online survey of residents across Mexico City demonstrate these downstream effects of organizing, even across unrelated issues.
Europe: Divided Over AUKUS and China
Authors: Mouritzen Hans
Published: September 2023

The AUKUS deterrence strategy towards China contrasts with the more cooperative EU Indo-Pacific strategy. In Europe, this can be traced to the fact that the UK and France/Germany support different geopolitical world views. European (and possibly Western) cohesion requires that geographical and geo-economic heterogeneities, together with Chinese wedging, are overcome. This can only happen, if at all, if the expensive partner receives a significant “solidarity reward.”
Dynamic 3D effects of single fiber tensile break within unidirectional composites including resin plasticity, residual stress, interfacial debonding and sliding friction
Authors: Ganesh Raja , Gillespie John W
Published: September 2023

To study the dynamics of a single fiber tensile break within an S-Glass/epoxy composite and the associated effects of stress wave propagation in the fibers, interface and matrix, a 3D micromechanical Finite Element (FE) model with a hexagonal packing of parallel fibers is developed. The effects of a dynamic fiber break on energy dissipation associated with resin plasticity and interface debonding using cohesive traction laws are included. The 3D FE model also incorporates process-induced residual stresses that induces radial compression at the fiber-matrix interface due the mismatch in CTE and Poisson’s ratios between the fiber and matrix. During dynamic fiber failure where interface debonding occurs, radial compressive residual stresses lead to additional frictional energy dissipation in the debond region of the interface. A map of the dynamic stress concentration factor (SCF) values on the surface (along the axial as well as circumferential directions) of the fibers which are neighboring the fiber break is generated. A stability criterion based on an energy balance between elastic strain energy released by the fiber and energy dissipation (resin plasticity, interphase debonding and frictional sliding) is established to predict maximum fiber strength that initiates unstable debonding of the interface characteristic of axial splitting of the unidirectional composite loaded in tension. The FE modeling results also indicate that the dynamic fiber break introduces strain rates on the order of 106/s in the fiber and matrix, and up to 1012/s in the interphase.
A Critique of Abraham Maslow and Carl Rogers as Educators
Authors: Feigenbaum Kenneth D.
Published: September 2023

In this article, the author examines the thoughts of Abraham Maslow and Carl Rogers on teaching and higher education themes, particularly the humanistic psychology approach to education. It reviews Maslow’s expert introduction of materials on psychology, literature, ethics, and philosophy in class, which demonstrates an interdisciplinary approach to teaching students. Maslow developed ideal core goals for college, emphasizing student creativity and experiences in the educational process, whereas Rogers tended to take a humanistic psychology approach to teaching. His philosophy emphasizes student-centered learning and client-centered therapy. Rogers considered the teacher a facilitator of learning, who builds relationships with students based on empathy, trust, and prioritizing of student needs, whereas Maslow adopted a hybrid position on education. His undergraduate teaching views included a student-directed curriculum and degrees of empathic involvement; yet he maintained a disciplinarian expert’s authority. His approach is also compared with that of graduate education. By contrast, Rogers’s view on education was homogeneous, making no distinctions as to what a student is supposed to learn at each level. This article compares the educational perspectives of two “giants” of humanistic psychology.
The Positive Impact of Combining Motor Imagery, Action Observation and Coach’s Feedback on Archery Accuracy of Young Athletes
Authors: Gmamdya Hatem , Souissi Mohamed Abdelkader , Bougrine Houda , Baaziz Mohamed , Noomen Guelmami  , Majdi Bouazizi , Robin Nicolas , Bali Naila
Published: September 2023

In recent years, learning and motor control researchers have examined, in diverse ways, the practical strategies that enhance motor skill acquisition in sport. In this study we investigated the impact of combining Motor Imagery (MI), Feedback (F), and Action Observation (AO) on the quality of archery longbow shooting at a 10-meter target. We randomly assigned 60 young athletes to (a) a Control group (Control), (b) a Feedback and Motor Imagery group (F + MI), and (c) a Feedback, Motor Imagery, and Action Observation group (F + MI + AO). Over an 8-week intervention period athletes performed two training sessions per week. During each session, all participants engaged in two blocks of ten effective shots. Performance improvement was significantly greater in the F + MI + AO group than in the two other groups, confirming the beneficial impact of combining all three methods of improving archery accuracy. These findings suggest practical recommendations for athletes and trainers for delivering optimal mental training to improve shooting accuracy for these archers.
Don’t Isolate Yourself in Workplace: A Serial Mediation Model of How Does Relationship Conflict Reduce Knowledge Employee’s Creativity
Authors: So Chungwai , Yao Qichun , Lin Xinyue , Du Juan
Published: September 2023

Past studies have revealed that relationship conflict has negative effects on individual performance. To avoid the losses caused by such conflicts, individuals often choose to avoid interacting with coworkers instead of confronting the issues. However, our present study sheds light on the dark side of this avoidance strategy: it may diminish an individual’s creativity. Our study aimed to examine the appropriate response for knowledge employees when faced with relationship conflict. The results indicate that relationship conflict triggers a sequential response, which significantly hampers the creativity of knowledge employees. Specifically, coworker ostracism and knowledge hoarding play serial mediating roles in the impact of relationship conflict on the creativity of knowledge employees. Furthermore, the level of emotional intelligence determines the ability of knowledge employees to effectively manage the negative consequences of relationship conflict. The results provide theoretical and practical insights that help to better explain the impact of relationship conflict on creativity.
Trapped in a Pathological Paradigm: Critiques of Suicidology Scholarship and Practice
Authors: Jackson-Lowman Huberta , Chioneso Nkechinyelum A. , Utsey Shawn O. , Williams Steven C.
Published: September 2023

Suicide among Africana youth, ages 10–19, is increasing at a faster rate than all ethnoracial groups in the US. Over four decades, epidemiological data reveal an upward trend in Africana youth suicidal behavior. We contend that the rising rates of Africana youth suicide cannot be effectively addressed because suicidology is trapped in a pathological paradigm based on the imposition of European cultural hegemony. Focusing on Africana youth, two critiques are presented. First, the inefficacy of universalism as a standard in suicidology is delineated. Intrapsychic, individually oriented approaches are overemphasized and a culturally incongruent epistemology undergirds scientific methodologies; thus, advancing culturally dystonic suicide prevention/intervention efforts. Second, the underinvestigated role of contextual oppressive factors in gender disparities discussions, risk factors impacting Africana youth, and the salience of social integration as a protective factor are deconstructed. Recommendations for multidisciplinary training/curricula, collaboration with social justice organizations, and supporting culturally defined and practice-based evidence approaches are outlined.
Active versus expectant management for premature rupture of membranes at term: A randomized, controlled study
Authors: Awkadigwe Fredrick I. , Ezugwu Frank O. , Eleje George U. , Nweze Sylvester O. , Odugu Boniface U. , Dinwoke Victor O. , Olu Ephraim A. , Ortuanya Kelvin E. , Ezenwaeze Malachy N. , Eze Obiechina C. , Onyekpa Johnson I. , Ofor Ifeanyichukwu J. , Onah Osmond O. , Omeje Chimdalu U. , Ezike Andre U. , Enyinna Perpetua K. , Malachy Divinefavour E. , Okafor Chigozie G.
Published: September 2023

Objective

To compare the effects on feto-maternal outcomes of expectant versus active management for premature rupture of membranes (PROM) at term.

Methods

This was a prospective randomized (1:1) controlled study involving 86 pregnant-women who received either expectant management (n = 43) or active management with misoprostol (n = 43) for PROM at term. Primary outcome was route of delivery. Secondary outcomes were: PROM to presentation interval; latency period; PROM to delivery interval; recruitment to delivery interval; labour and delivery complications.

Results

Baseline-characteristics were similar between groups. There was no significant difference between active and expectant groups in mean PROM to presentation/admission, or PROM to delivery. However, mean latency period (11.1 ± 7.3 hours vs 8.8 ± 5.5 hours) and mean recruitment to delivery intervals after PROM (14.7 ± 5.2 hours vs 11.8 ± 5.0 hours) were significantly shorter for the active group compared with the expectant group. Although the rate of caesarean section was less in expectant management group (21%) compared with the active management group (30%), the difference was not statistically significant. There were no significant differences between groups in delivery or perinatal complications.

Conclusion

Active and expectant management for PROM at term gave comparable outcomes in terms of methods of delivery and complications. However, active management significantly shortened the latency period and induction to delivery intervals compared with expectant management. Trial-Registration: Pan-African-trial-registry-(PACTR)-approval-number PACTR202206797734088
Comparing effects of sad melody versus sad lyrics on mood
Authors: Pond Nathan , Leavens David
Published: September 2023

While researchers have consistently found that music can evoke discrete emotions in people cross-culturally, there is little consensus regarding the mechanisms underpinning this effect. The present study aimed to gain further insight into how music influences emotions, investigating whether the lyrics or the melody of a sad piece of non-classical music had a greater influence on mood. The researchers presented a sample of 251 participants with isolated melody, isolated lyrics, and the original version of a sad pop-ballad in turn, measuring the influence of each on mood using the Brief Mood Introspection Scale (BMIS). A one-way repeated measures ANOVA revealed that all versions of the song significantly reduced mood scores from baseline, with the isolated lyrics and original version of the song reducing mood to a greater magnitude than the melody. The results suggested that both the lyrics and melody of the music influenced mood, though the lyrics appeared to do so to a greater extent. Furthermore, a thematic analysis of open-response questions provided preliminary evidence that the semantic content of lyrics was more influential on mood than the vocal expression of lyrics. Future research should aim to replicate these findings, using both positively and negatively emotionally valenced musical stimuli.
Impact of recycled polypropylene on the specific properties of stretched polypropylene tapes for woven bag
Authors: Daoudi Hamza , Semlali Fatima-Zahra , Kassab Zineb , Ablouh El-Houssaine , Bouhfid Rachid , Qaiss Abou El Kacem , El Achaby Mounir
Published: September 2023

To create woven bag packaging for Nitrogen-Phosphorus-Potassium (NPK) fertilizer granules, this work conducted an experimental study on the utilization of recycled polypropylene (RPP) in stretched polypropylene (PP) tapes. By altering the amount of RPP using an industrial-scale stretching tapes extrusion technique, the as-obtained RPP granules were utilized to develop three stretched tape composite series filled with 0.9, 2.8, and 3.6 wt% of RPP, respectively. The series of produced composites were described in terms of their structural, rheological, mechanical, and thermal characteristics. It was found that the inclusion of RPP into PP stretched tape composites improved the composites’ rigidity but reduced their toughness, due to the cumulative legacy effect of calcite particles and the RPP oxidative effect from the reprocessing history. However, RPP has shown good results in terms of storage modulus and strain at break, hence can be utilized in textile and engineering applications.
Construction and demolition waste framework of circular economy: A mini review
Authors: Papamichael Iliana , Voukkali Irene , Loizia Pantelitsa , Zorpas Antonis A
Published: September 2023

As the demand for materials continues to increase and building lifespans shorten, the construction industry faces mounting pressure to reduce its material and environmental impacts. Mismanagement of construction and demolition waste (CDW) can have severe environmental consequences. To address this, material recovery and circular economy approaches offer significant potential for reducing construction waste through the sustainable use of resources. Existing circular economy and material recovery models that prioritize recycling and reuse efforts demonstrate a sustained commitment to supporting circular practices in the construction and demolition sector. The goal is to minimize waste production, which poses environmental challenges such as raw material shortages and sustainability concerns. Using Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement for recruiting relevant literature, this mini review aims to identify the obstacles to implementing circular economy practices in the construction industry, while exploring opportunities for material recovery and circularity. The ultimate aim is to facilitate a fair and smooth transition towards sustainable development, while addressing environmental, social and economic barriers. A more sustainable and circular approach to building construction and management can be attained by considering all the aspects of the CDW cycle, resulting in significant benefits for the environment and society as a whole.
Changes in the Correlates for Intimate Partner Violence Against Women in Vietnam: Evidence From the 2010 and 2019 National Prevalence Surveys
Authors: Vyas Seema , Jansen Henrica A.F.M. , Viet Nga Nguyen Thi , Gardner Jessica , Loan Tran Thi Bich , Phan Hien
Published: September 2023

This study sought to understand whether the risk and protective factors associated with current partner violence changed in Vietnam using findings from two comparable surveys conducted in 2010 and 2019. Fifteen (2010) and 17 (2019) factors were significantly associated with violence, and the level of consistency was high—nonpartner sexual violence, respondent and partner prior abuse, men's expressions of masculinity, and indicators of low economic status continue to put women at risk. Gender-transformative approaches that address power inequalities, foster positive parenting, and promote the political and social influence of women are required and should be adapted to the Vietnam context.
Evaluation of proteinuria monitoring practice patterns and treatment implications in patients with cancer receiving bevacizumab products
Authors: Sturgill Kuan , Dicke Katie , Zangardi Mark , Osborne Kara
Published: September 2023

Introduction

Proteinuria is a well-known toxicity of bevacizumab which can lead to kidney injury or nephrotic syndrome. There is little guidance on the frequency of monitoring and management of those that experience bevacizumab-induced proteinuria. Previous literature has suggested routine monitoring with every dose has limited clinical significance. Currently, there is no standardization of proteinuria monitoring at OhioHealth.

Methods

This retrospective descriptive study included 100 adult patients who received at least 3 doses of a bevacizumab product for a malignant condition at any OhioHealth facility from April 15, 2022 to October 15, 2022. The primary outcome was to describe the average number of proteinuria tests ordered over the course of therapy.

Results

Of the 100 patients evaluated, 91 received proteinuria monitoring during treatment with bevacizumab. The overall average number of tests completed per patient per month based on treatment period of bevacizumab was 1.51. Twenty-two of 91 patients (24%) developed grade 2+ proteinuria. Average time to first grade 2+ proteinuria event was 5.7 months. A history of baseline renal dysfunction or chronic kidney disease was the only predefined factor found to be significantly associated with developing grade 2+ proteinuria. The most common treatment modification following a grade 2+ proteinuria result was a delay in therapy.

Conclusion

Proteinuria monitoring may not be necessary for short definitive courses of bevacizumab and closer monitoring should be considered in patients with baseline renal dysfunction or CKD. Future direction includes evaluating the cost of varying proteinuria tests and developing a recommendation for OhioHealth to standardize testing.
Pressure–Volume Loops for Reviewing Right Ventricular Physiology and Failure in the Context of Left Ventricular Assist Device Implantation
Authors: Bouchez Stefaan , Erb Joachim , Foubert Luc , Mauermann Eckhard
Published: September 2023

Right ventricular (RV) function is complex as a number of determinants beyond preload, inotropy and afterload play a fundamental role. In particular, arterial elastance (Ea), ventriculo-arterial coupling (VAC), and (systolic) ventricular interdependence play a vital role for the right ventricle. Understanding and actively visualizing these interactions in the failing RV as well as in the altered hemodynamic and morphological situation of left ventricular assist device (LVAD) implantation may aid clinicians in their understanding of RV dysfunction and failure. While, admittedly, hard data is scarce and invasive pressure-volume loop measurements will not become routine in cardiac surgery, we hope that clinicians will benefit from the comprehensive, simulation-based review of RV pathology. In particular, the aim of this article is to first, address and clarify the pathophysiologic hemodynamic factors that lead to RV dysfunction and then, second, expand upon this basis examining the changes occurring by LVAD implantation. This is illustrated using Harvi software which shows elastance, ventricular arterial coupling, and ventricular interdependence by simultaneously showing pressure volume loops of the right and left ventricle.
Adolescence Mental Health Disorders and Precarious School-to- Work Trajectories: The Role of Family Background and Gender
Authors: Jensen Maria Reinholdt , Hermansen Åsmund
Published: September 2023

This article investigates the role of family socio-economic status (SES) as a buffer for adolescents with mental health disorders (MHDs) against entering precarious school-to-work trajectories. We follow a cohort born in Norway in 1992 from the age of 16–25 using data from administrative registers. We find that externalizing disorders, to a higher degree than internalizing disorders (registered in the 16–18 age range), are associated with subsequent precarious school-to-work trajectories (measured from January 2011 to December 2017) for both genders. In boys, high family SES seems to buffer the negative impact of externalizing disorders on entering precarious school-to-work trajectories, but not for internalizing disorders. In contrast, in girls, high-SES families partly buffer the negative impact of internalizing disorders, but not for externalizing disorders. Thus, this paper broadens the current perspective on how the impact of MHDs on entering school-to-work trajectories is interrelated with social class and gender.
Are the local sky temperature models and the global thermal standard model EN ISO 6946(2017) numerically compatible?
Authors: Ficker Tomáš
Published: September 2023

Local sky temperature models are often used by researchers to improve the estimation of building heat losses. Besides the local sky temperature models, there is a global temperature model implemented in EN ISO 6946(2017) that may also produce reasonable results if it is conveniently applied. To assess the competitiveness of global and local models, it is desirable to perform a direct numerical comparison of their results. Such a comparison has not been published so far. This study aims to analyze the computational differences between three models of sky temperature, namely, the Swinbank model, the universal model and the standard model implemented in EN ISO 6946(2017). The study verifies the robustness of the global thermal standard model to account for the acting of the cold sky on building envelopes compared to local sky models specially designed for this purpose. The quasi-nocturnal conditions are supposed to reveal the main features of the long-wave infrared interactions between the building facade and the sky. The study has proved the capability of the global standard model to successively compete with the local sky temperature models at least within the conditions of the quasi-nocturnal environment.
Assessment of a hydraulic bottle jack as an effective device for controlling vibration and mitigating the effects of earthquakes
Authors: Wahrhaftig Alexandre de Macêdo , Menezes Cibele Mota , Conceiçao Rodrigo Oliveira da Silva , Oliveira Iago Goncalves de , Ozdemir Ozge
Published: September 2023

The aim of this work was to assess the capability of a hydraulic bottle jack to control vibrations and the effects of earthquakes. The first stage of the present investigation focused on determining the axial stiffness of the apparatus, in order to relate its behavior to that of a linear elastic element. To do this, uniaxial compression tests were carried out using a manually controlled servo system. In the second stage, a conceptual application based on the field of mechanical vibrations was considered. The experimental results confirmed the hypothesis of linear behavior and showed that the stiffness coefficient had distinct values of magnitude that depended on the cylinder height. Simulations were conducted in which the frequencies and the peak displacements of an idealized SDOF system subjected to earthquake excitation were adjusted based on the experimental stiffness. It was possible to conclude that the equipment analyzed here is an effective tool for controlling vibration and reducing displacement during a seismic event, and can be calibrated according to the specific conditions of operation. This is an important aspect of safety and functionality for mechanical and structural systems.
Initial boundary layer state of typical model-scale jet nozzles and its impact on noise
Authors: Zaman KBMQ
Published: September 2023

A set of 2-inch diameter nozzles is used to investigate the effect of varying exit boundary layer (BL) states on the radiated noise from high-subsonic jets. It is confirmed that nozzles involving turbulent boundary layers are the quietest while others, involving nominally-laminar BLs, are noisier. A turbulent BL is thicker and there is simply an effect of thickness on noise. A thicker BL results in a decrease in the sound pressure spectral amplitudes due to a less vigorous growth of instability waves in the jet’s shear layer. A nominally-laminar BL, besides being thinner, may also involve significantly higher turbulence intensities, much higher than that in a turbulent BL. Such a BL state, referred to as ‘highly disturbed laminar’, results in the largest noise amplitudes especially on the high-frequency side of the spectrum. This transitional state, often encountered with model scale nozzles, involves a ‘Blasius-like’ mean velocity profile but large velocity fluctuation intensities and intermittency. The higher initial turbulence adds to the increase in high-frequency noise. The results leave little doubt that an anomaly noted with subsonic jet noise databases in the literature is due to similar effects of differences in the initial boundary layer state.
Attentional control systems for emergent strategic issues in the post-Chandlerian world
Authors: Love E Geoffrey
Published: September 2023

Scholars have recently emphasized a need to advance the attention-based view to account for a new “post-Chandlerian” environment wherein firms organized along Chandlerian m-form lines are increasingly unable to cope with rapid and discontinuous changes and strategic issues that can emerge anywhere in the organization. This article works to make such an advance by drawing on the underdeveloped idea of attentional control—that is direction of members’ attention—within the attention-based view. The article develops the concept of attentional control systems and, as its core contribution, proposes that firms can use issue-specific emergent attentional control systems to address emergent strategic issues that are characteristic of post-Chandlerian environments. Key components of these systems include emergent, issue-specific communication channels, reconfigured roles, and interactive control practices. These three interrelated attentional control mechanisms enable attentional dynamism and high-quality attention to be directed toward emergent strategic issues, thus mediating effective strategic decision-making as well as resource commitment and ultimately enhancing strategic adaptation.
“I don’t like to ask for charity”: The possibilities of social inclusion among immigrant low-income Latina mothers via feminist action research
Authors: Cedeño Diana
Published: September 2023

This Feminist Action Research (FAR) examines the impact of economic and societal exclusion on low-income Latina mothers. The study, conducted in an urban community in the Northeast U.S., aimed to foster social inclusion among low-income Latina mothers via a financial intervention. Data were collected from 12 participants, and the intervention emphasized curriculum negotiation and critical thinking. Descriptions and roles of positionality are considered and contextualized. Findings exemplified economic and societal exclusion in the form of economic deprivation and experiences of discrimination, along with experiences of personal agency, solidarity, and social inclusion. Conclusions include a discussion on the potential of FAR within poverty research, along with practical implications in developing community change.
Dimensionless study of the fiber arrangement on particle filtration characteristics in a multi-fiber filter
Authors: Fan Jianhua , Yang Kun , Zhang Liang , Wang Lu , Han Zhiwu
Published: September 2023

In this paper, two-dimensional numerical simulations are performed to investigate the particle filtration performance of multi-fiber filters using computational fluid dynamics ( CFD) technology. We combine fluid and particle properties as well as fiber size into single dimensionless numbers to analyze the influence of fiber arrangements on the system pressure drop and capture efficiency during the filtration process. The results indicate that the motion and deposition of aerosol particles significantly depend on the combined effects of Brownian diffusion, interception and inertial impaction mechanisms. The capture of aerosol particles with diameters less than 0.1 [Formula: see text] is strongly determined by the Brownian diffusion mechanism. For the case where interception and inertia impaction mechanisms dominate, particles with diameters in the range of 1–10 [Formula: see text] are more easily captured. In addition, the filter with a staggered fiber array structure exhibits a higher capture efficiency than that of parallel and random cases. From the quality factor standpoint, filters with both the staggered and random fiber arrangements show a better filtration performance. The research results can provide a fundamental understanding of the particle filtration process and the theoretical basis for filter design and optimization.
Risk Factors for Ulcer Recurrence in Diabetic Patients Managed by an Integrated Foot Care Protocol
Authors: Giurato Laura , Andrea Panunzi , Meloni Marco , Pecchioli Chiara , D’Ambrogi Emanuela , Uccioli Luigi
Published: September 2023

The aim of our study was to identify risk factors for the recurrence of diabetic foot ulcers (DFUs) in a selected population of patients in secondary prevention treated, according to International Guidelines, with an integrated foot care protocol by a referral diabetic foot clinic. A retrospective study was performed with the inclusion of selected outpatients with diabetes at higher risk for ulceration with a history of previous ulcer and/or amputation followed in our diabetic foot clinic between January 2015 and December 2021. According to the presence or absence of recurrence, patients were divided into 2 groups: ulcer recurrence and without ulcer recurrence. One hundred twenty-seven (127) patients were included, 47 patients (37%) developed an ulcer recurrence while 80 patients (63%) did not. The mean age was 71.7 years; 65% were male; 97% were affected by type 2 diabetes with a mean duration of 21.1 years, the mean HbA1c was 63 + 21 mmol/mol. Both groups of patients had foot deformities, such as claw and hammertoes; hallux valgus, and prominent metatarsal heads (MTHs). The presence of deformity was significantly associated with ulceration. The group with ulcer recurrence showed a higher rate of prominence MTHs in comparison to a group without ulcer recurrence. The MTHs resulted as the only independent predictor for recurrence. This study shows that the presence of the prominent MTH is a significant risk factor for ulcer recurrence in a selected population of diabetic foot patients treated in the best way with integrated foot care.
Epidemiology of adult hand injuries presenting to a tertiary hand surgery unit: a review of 4216 cases
Authors: Kankam Hadyn K. N. , Ibrahim Hussein , Liew Mei Sien , Hauff Ellie , Tullie Sebastian , Parthiban Sunil , Chester Darren L.
Published: September 2023

This study investigates the pattern of hand injuries presenting to a UK regional tertiary centre. All referrals to our Hand Surgery Unit in 2019 were reviewed. Subgroup analyses of sex, deprivation, occupational injuries and assault cases were carried out. Over the study period, 4216 cases were referred. Most were male (70%), with a median age of 36 years and from a deprived area (75.2%). Soft tissue injury was documented in 53.6% and bone injury (fracture/dislocation) in 52.4%. Surgical management was required in 2214 (52.5%) cases. Work-related injuries accounted for 16.7% of cases and were more likely to require surgery. Assault-related injuries accounted for 8% of cases, with a male preponderance. Our findings can help facilitate service provision and guide regional and national prevention policies.

Level of evidence: III