bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of using different biological products on IL-1β TNF-α, PGE2 concentrations in rabbits with periodontitis
Authors: Salim Jaafer Samer , Ben Amor Faten
Published: August 2024

Introduction: Platelet‐rich plasma (PRP) is a plasma fraction of autologous blood with a high platelet concentration, containing key cytokines and growth factors.Methods: This study, conducted in the Clinical Surgery Department of the College of Dentistry, University of Al-Muthanna, involved 20 New Zealand white rabbits divided into four groups. A 1mm gingival wound was created on each rabbit, followed by immediate injections:10μl saline10μl PRP10μl Platelet‐poor plasma (PPP)3ng hepatocyte growth factor (HGF) in 10μl engineered tendon matrixRabbits were sacrificed on days 0, 1, 3, 5, and 12 for tissue harvesting.Results: Interleukin 1 beta Increased in PPP group compared to HGF, PRP, and control groups. Tumor Necrosis Factor alpha: Increased in PPP group.While,PRP significantly reduced PGE2 levels on days 1, 3, and 5. On day 12, levels were low in both PRP and control groups. PPP slightly reduced PGE2 on days 1, 3, and 5. HGF reduced PGE2 on days 1, 3, and 12, with a transient response on day 0.Conclusion: PRP sustains the up-regulation of proinflammatory factors like Interleukin 1 beta and Tumor Necrosis Factor alpha. Its anti-inflammatory function is partially mediated through HGF, producing similar anti-inflammatory effects.
Evaluation of learning from an articulating axis: A formative experience
Authors: Orjuela Roa Cristian Harrison , Bustos Fuentes Yeimy Katherine , Plaza Maldonado Rodrigo , Lesmes Martínez Óscar Mauricio , Castañeda Polanco Juan Gabriel
Published: August 2024

Introduction: Learning evaluation in Colombia is regulated, implemented, and established under a training and competency approach. However, there are many challenges that this entails due to the complexity and domain of the evaluative actions managed by educational institutions.Objective: Evaluate the scope of an articulating axis of the area of natural sciences from the first to the eleventh grade, through the competency performances that are established for a learning journey.Methods: A cross-sectional design was used to evaluate students' competencies from an articulating axis; data were collected between November 2022 and February 2023 in an unofficial educational institution. The sample was 827 students and correlates with convenience sampling. They were applied eleven instruments that complied with the DCE and their respective validation.Results: Significant differences were observed between the competency performances for the grades evaluated, especially in primary school, which defined the behavior of the competencies and learning that were evaluated on the axis. The visualization on the dynamic dashboard shows the patterns and regularities for each level of performance, allowing the identification of learning that required strengthening.Conclusions: An articulating axis in the natural sciences was evaluated through a focus on structuring competencies and learning between the grades of the curriculum. This allowed us to question traditional evaluation and promote a formative evaluation that detects specific weaknesses, facilitating pertinent improvements.
Trends in research on nature tourism-induced diseases in the SCOPUS database
Authors: Sánchez-Castillo Verenice , Ávila Romero Rita , Juárez Olascoaga Bernardo Gerardo
Published: August 2024

Tourism is a multidimensional activity that involves various economic, social, cultural and environmental aspects, and among the types of tourism, nature tourism can be a risk factor for health, as travellers can be exposed to various diseases. The aim of the research is to analyse research trends on diseases caused by nature tourism in the SCOPUS database. The research paradigm is quantitative, based on a bibliometric study, using a descriptive and retrospective approach. Only review and research articles were considered, without language restriction. The behaviour of the research was positive and increasing, with a maximum peak of 30 research papers, predominantly research articles in the area of environmental sciences. The most productive country with 25 papers was the United States, while the most prominent affiliation was Griffith University with four research papers from Australia. Three lines of scientific research and the most productive authors in the subject were identified, as well as an analysis of the citation levels in the period. Nature tourism, also referred to in the literature as ecotourism or green tourism, is a type of travel that focuses on the exploration and enjoyment of nature's diversity, allowing travellers to connect with the land and biodiversity
Cesarean Section: Medical, Social and Moral and Ethical Factors
Authors: Omarova Gulzhakhan , Sultanova Zhanat , Aimbetova Aliya , Saduakassova Shynar , Yuldasheva Ainura
Published: August 2024

Introduction: a cesarean section (C-section) is a surgical procedure used to deliver a baby through incisions in the abdomen and uterus. It is a common procedure, but it carries various medical, social, moral, and ethical considerations.Objective: to evaluate medical, social, moral, and ethical factors related to cesarean sections.Method: conducted a descriptive cross-sectional study on 100 pregnant women undergoing cesarean sections using nonrandom purposive sampling. Data (quantitative and qualitative) collected through a pretested questionnaire, analyzed with SPSS 26 and Atlas.ti.Results: significant associations were found in age (p=0,033), education (p=0,043), socioeconomic status (p=0,046), and BMI (p=0,048). Obstetric factors, including parity (p=0,033), delivery place (p=0,035), child weight at birth (p=0,000), and major indications for CS (p=0,048), demonstrated substantial impact. Ethical considerations showed significant associations with maternal autonomy (P=0,040), medical necessity (P=0,038), resource allocation (P=0,038), bonding impact (P=0,037), unnecessary interventions (P=0,033), reproductive autonomy (P=0,046), cultural sensitivity (P=0,028), and provider accountability (P=0,042).Conclusions: study emphasizes tailored maternal care, reveals sociodemographic, obstetric influences, intricate ethical dimensions
Exploring computational methods in the statistical analysis of imprecise medical data: between epistemology and ontology
Authors: Nieto Sánchez Zulmary Carolina , Bravo Valero Antonio José
Published: August 2024

The accuracy of the results is essential to evaluate the effectiveness of statistical methods in the analysis of medical data with uncertainty. Indicators such as margin of error, percent agreement and coefficient of determination quantified accuracy under epistemic and ontological uncertainty. The stability of the methods was assessed by variation in trend analysis, sensitivity to small variations and model robustness. Data reliability focused on the selection of methods that effectively handle epistemic uncertainty, recording assumptions, sensitivity analysis and internal consistency. Ontological imprecision was quantified using the fuzzy membership degree and the overlap coefficient. The exploration of computational methods underlined the importance of accuracy and the handling of epistemic and ontological uncertainty, ensuring reliable results. The geometric mean filter, with a score of 0,7790, stood out as the best for its accuracy and ability to effectively handle uncertainty
Community Health Workers and mHealth: adoption of strategies for the prevention of cervical cancer in Argentina
Authors: Sánchez Antelo Victoria , Paolino Melisa Paolino , Arrossi Silvina
Published: August 2024

Introduction: the ATICA strategy was a multicomponent mHealth intervention based on sending SMS messages to HPV+ women to promote triage cytology. After 60 days, an email and a SMS message were also sent to the Community Health Worker (CHW) to visit women who had not attended triage. Aim: to analyze the perceptions of CHWs about barriers and facilitators of the implementation of the multicomponent intervention and their intention to adopt it.Methods: we evaluated the implementation of the intervention using the Consolidated Framework for Implementation Research (CFIR) and RE-AIM framework. CHWs were asked to complete an anonymous, self-administered survey to evaluate their intention to adopt the intervention and to identify barriers and facilitators. We measured the association between intention to adopt the ATICA strategy and CFIR constructs. We used IBM SPSS software to calculate the chi-square and evaluate associations.Results: of the 221 CHWs in the ATICA study, 197 completed the survey. 78,3 % of them would adopt the strategy in their work without differences between sociodemographic profiles or according to familiarity with phone use. The intention to adopt ATICA was higher among those who perceived it as a relative advantage (81 % vs. 62,5 %; p=0,04) and among those who found it easy to register phone numbers (81,8 % vs. 64,3 %; p=0,04). 98,3 % stated that strategies were needed to expand triage coverage in the province.Conclusion: the high intention to adopt the ATICA strategy among CHWs will contribute to the future scaling-up of the intervention
Cognitive skills and critical thinking interventions for the development of academic writing in higher education students: a systematic review
Authors: Sandoval-Cárcamo Joselin , Arias-Roa Nicole , Arancibia-Gutiérrez Beatriz Magaly
Published: August 2024

This systematic review examines interventions designed to improve academic writing skills and emphasizes the importance of interaction between students, instructors, and/or writing tutors during the composition process.The main objective of this review is to characterize the interventions focused on cognitive skills for the development of academic writing in higher education students that have been implemented in Latin American and Ibero-American countries.To carry out this Systematic Review, the PRISMA recommendations were followed and, in addition, a documentary research and content analysis strategy was implemented with the purpose of examining the different definitions of cognitive abilities used in the selected studies.In total, nine articles that met the established criteria were identified and analyzed. A comprehensive and updated view of interventions aimed at improving academic writing skills in the context of higher education is offered, focusing on the application of cognitive skills and critical thinking as key tools for this purpose
The effects of professional identity on retention intention of international Chinese language teachers in Guizhou colleges and universities: The chain mediating role of job satisfaction and career commitmen
Authors: Wu Zudan , Fu Jianping
Published: August 2024

This study investigates the influence of international Chinese language teachers' professional identity on their intention to stay in Guizhou universities. The focus is on understanding the chain mediating role of job satisfaction and career commitment in this relationship. Objectives: The primary objective is to analyze the correlation between teachers' professional identity and their intention to stay in the profession. Additionally, the study aims to evaluate the mediating effects of job satisfaction and career commitment on this relationship. Methods: Data were collected from international Chinese language teachers working in Guizhou universities. Statistical analysis was conducted to examine the relationships among professional identity, job satisfaction, career commitment, and intention to stay. Results: The analysis revealed a significant positive correlation between teachers' professional identity and their intention to stay in the profession. Furthermore, both job satisfaction and career commitment were found to play crucial mediating roles in this relationship. Conclusions: The findings suggest that enhancing teachers' professional identity and job satisfaction, as well as strengthening their career commitment, can effectively increase their willingness to remain in the profession. This is critical for stabilizing the teaching workforce and improving educational quality. The study provides valuable insights for university administrators to develop more reasonable and effective teacher management and incentive policies
The Influence of Family Factors on Emotional Intelligence in ABK
Authors: Oktavia Oktavia , Aprianif Aprianif
Published: August 2024

This study aims to analyze the influence of family factors on the emotional intelligence of children with special needs (ABK) at Al Ihsan 01 Special School in South Tangerang. Emotional intelligence is measured as the dependent variable, while the independent variables in this study include gender, child’s age, family economic factors, mother's age during pregnancy, parental education, and the presence of a special assistant. Data was collected through questionnaires distributed to parents and interviews with teachers, based on Goleman’s (2009) emotional intelligence indicators. The results of this study are expected to provide a deeper understanding of the role of family factors in the development of emotional intelligence in children with special needs and offer recommendations for more effective educational strategies in special schools
Southeast Asian Identity Culture: Dynamics, Diversity, and Integration in the Context of Globalization
Authors: Abbasovna Abbasovna
Published: August 2024

This research explores the dynamics of identity culture in Southeast Asia, focusing on how globalization affects and shapes cultural identities in the region. Using a literature review approach, this study analyzes various literature sources to identify key themes related to cultural diversity, the influence of globalization, and cultural hybridity. Key findings show that Southeast Asia has a rich cultural diversity, with each country in the region displaying unique traditions and customs. However, globalization brings challenges in the form of cultural homogenization that threatens local uniqueness. Nonetheless, Southeast Asian societies also demonstrate adaptability through cultural hybridity, reflecting the merger of traditional and global elements. This research highlights the importance of preserving local culture while participating in the flow of globalization and proposes policies that support cultural education as well as the preservation of local heritage. These findings provide new insights into how cultural identities in Southeast Asia continue to evolve and transform amid global change.
Peran Media Sosial dalam Pemasaran Online Bolen Gita di Kota Tangerang
Authors: Hermana Muhammad Fajrin , Kafi Vivi , Fahira Fitya
Published: August 2024

Penelitian ini bertujuan untuk mengeksplorasi peran penting media sosial, khususnya Instagram dan WhatsApp Business, dalam strategi pemasaran online UMKM Bolen Gita di Kota Tangerang. Sebagai pemilik bisnis, Gita memanfaatkan media sosial untuk membangun kesadaran merek, berkomunikasi langsung dengan pelanggan, menjangkau pasar yang lebih luas, serta mengumpulkan masukan yang berharga. Melalui Instagram, Gita mampu menampilkan produknya secara menarik dan inspiratif, sementara WhatsApp Business memberikan platform untuk interaksi langsung dan personal dengan pelanggan. Penelitian ini menggunakan pendekatan kualitatif dengan teknik purposive sampling, yang melibatkan observasi langsung dan wawancara. Hasil penelitian menunjukkan bahwa Gita berhasil mengelola akun media sosialnya secara efektif untuk mengembangkan bisnisnya, meningkatkan minat dan loyalitas pelanggan melalui pendekatan yang lebih personal dan interaktif.
EFFECT OF STATIC OPENER IN THORACIC OUTLET SYNDROME: A CASE REPORT
Authors: VERMA VISHAL , BIJALWAN KUNAL , KASHYAP DIVYA , SANDILYA ABHISHEK KUMAR
Published: August 2024

Thoracic outlet syndrome (TOS), a challenging clinical scenario, arises from neurovascular compression within the thoracic outlet, resulting in upper extremity symptoms. This case study examines the effectiveness of the static opener technique, a conservative physical therapy approach targeting postural anomalies and muscle imbalances that contribute to TOS. A 45-year-old female office worker with persistent upper extremity pain, numbness, and weakness underwent a five-week intervention using the static opener method. Pre- and post-treatment objective assessments included pain intensity (Visual Analog Scale), numbness/tingling severity (Numeric Rating Scale), upper extremity strength (Manual Muscle Testing), and functional status (Disabilities of the Arm, Shoulder, and Hand questionnaire). The patient experienced a 50% reduction in pain intensity, a 57% reduction in numbness/tingling severity, improvement from 3/5 to 4/5 in upper extremity strength, and a 38% reduction in functional disability (as measured by the DASH score). The patient reported satisfaction with symptom relief and improved daily function. These findings suggest that the static opener technique may be a promising adjunctive therapy for managing TOS symptoms, and further research is needed to validate its effectiveness in larger, controlled studies.
Keywords: Thoracic outlet syndrome, postural anomalies, tingling, opener technique, physical therapy.
The public health and economic burden of long COVID in Australia, 2022–24: a modelling study
Authors: Costantino Valentina , Grafton Quentin , Kompas Tom , Chu Long , Honeyman Damian , Notaras Adriana , MacIntyre C Raina
Published: August 2024

Objective

To estimate the number of people in Australia with long COVID by age group, and the associated medium term productivity and economic losses.

Study design

Modelling study: a susceptible–exposed–infected–recovered (SEIR) model to estimate the number of people with long COVID over time following single infections, and a labour supply model to estimate productivity losses as a proportion of gross domestic product (GDP).

Setting

Australia, 2022–2024.

Main outcome measures

Estimated number of people infected with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) during 2022–2023 (based on serosurvey data) who have long COVID, 2022–2024, by age group; estimated GDP loss during 2022 caused by reduced labour supply attributable to long COVID.

Results

Our model projected that the number of people with long COVID following a single infection in 2022 would peak in September 2022, when 310 341–1 374 805 people (1.2–5.4% of Australians) would have symptoms of long COVID, declining to 172 530–872 799 people (0.7–3.4%) in December 2024, including 7902–30 002 children aged 0–4 years (0.6–2.2%). The estimated mean labour loss attributable to long COVID in 2022 was projected to be 102.4 million (95% confidence interval [CI], 50.4–162.2 million) worked hours, equivalent to 0.48% (95% CI, 0.24–0.76%) of total worked hours in Australia during the 2020–21 financial year. The estimated mean GDP loss caused by the projected decline in labour supply and reduced use of other production factors was $9.6 billion (95% CI, $4.7–15.2 billion), or 0.5% of GDP. The estimated labour loss was greatest for people aged 30–39 years (27.5 million [95% CI, 16.0–41.0 million] hours; 26.9% of total labour loss) and people aged 40–49 years (24.5 million [95% CI, 12.1–38.7 million] hours; 23.9% of total labour loss).

Conclusion

Widespread SARS‐CoV‐2 infections in Australia mean that even a small proportion of infected people developing long COVID‐related illness and disability could have important population health and economic effects. A paradigm shift is needed, from a sole focus on the immediate effects of coronavirus disease 2019 (COVID‐19) to preventing and treating COVID‐19 and treating long COVID, with implications for vaccine and antiviral policy and other mitigation of COVID‐19.
Gruplarla Sosyal Hizmet Uygulamalarında Travma Bilgili Yaklaşım
Authors: Pak Güre Merve Deniz , Çatulay Doğucan , Apaydın Yüsra Selin
Published: August 2024

Travma, bireyin başa çıkma yeteneğini aşan, işlevselliğini önemli ölçüde bozan, fiziksel, psikososyal ve bilişsel açıdan olumsuz etkilere neden olan bir olaya veya olaylar dizisine verilen tepkidir. Sosyal hizmet uzmanları şiddet, ihmal, istismar, hastalık, kayıp, afet ve göç gibi çeşitli travmatik yaşam olaylarını deneyimleyen müracaatçılarla çalışmaktadır. Sosyal hizmet uzmanları travmatik stres tepkileri gösteren müracaatçılarla grupla sosyal hizmet uygulamaları gerçekleştirmektedir. Travmanın çok yönlü etkileri, travmatik yaşam olayını deneyimleyen bireylerin ihtiyaçlarını karşılamaya yönelik etkili müdahale için özel bir çerçeve gerektirmektedir. Travmanın etkisini anlamayı, tanımayı ve tepki vermeyi içeren travma bilgili yaklaşım bunların başında gelmektedir. Bu çalışmanın amacı grupla sosyal hizmet uygulamalarında travma bilgili yaklaşımın nasıl kullanılacağı ile ilgili ilkelerin ortaya konulmasıdır. Travma bilgili yaklaşım, sosyal hizmet müdahalelerinin travma yaşayan bireylerin ihtiyaçlarına ve deneyimlerine duyarlı olmasını sağlayarak yeniden travmatizasyonu en aza indirmeyi, iyileşmeyi ve dayanıklılığı desteklemeyi amaçlamaktadır. Travma bilgili yaklaşımın güvenlik, güvenilirlik ve şeffaflık, güçlendirme, seçim, saygı, iş birliği ve karşılıklılık ilkeleri bulunmaktadır. Bu ilkeler grupla sosyal hizmet uygulamalarında güvenlik ve güven duygusunun oluşturulması, açık iletişimin ve karşılıklı saygının geliştirilmesi, seçim ve iş birliği yapabilmenin desteklenmesi ve nihai olarak güçlenmenin sağlanması için bir çerçeve sunmaktadır.
Peripheral lymphadenopathy of unknown origin in adults: a diagnostic approach emphasizing the malignancy hypothesis
Authors: Hanzalova Ivana , Matter Maurice
Published: August 2024

The term lymphadenopathy refers to an abnormality in size, consistency or morphological aspect of one or several lymph nodes. Although lymphadenopathies are commonly observed in everyday clinical practice, the difficulty of differentiating benign and malignant disease may delay therapeutic approaches. The present review aims to update diagnostic algorithms in different clinical situations based on the currently available literature.
A literature review was performed to assess current knowledge of and to update the diagnostic approach. A short clinical vignette was used as an example of a typical clinical presentation. This case of metastatic lymphadenopathy with incomplete patient history demonstrates how misleading such lymphadenopathy may be, leading to a delayed diagnosis and even a fatal outcome.
Any lymphadenopathy persisting for more than 2 weeks should be considered suspicious and deserves further investigation. Precise clinical examination, meticulous history-taking and a search for associated symptomatology are still cornerstones for diagnosing the origin of the condition. The next diagnostic step depends on the anatomical region and the specific patient’s situation. Imaging starts with ultrasound, while computed tomography (CT) and magnetic resonance imaging (MRI) allow assessment of the surrounding structures. If the diagnosis remains uncertain, tissue sampling and histological analyses should be performed.
Except for head and neck loco-regional lymphadenopathy, there are no methodical guidelines for persistent lymphadenopathy. The present review clarifies several confusing and complex situations. The accuracy of fine needle aspiration cytology could be increased by using core needle biopsy with immunocytologic and flow cytometric methods. Notably, except in the head and neck area, open biopsy remains the best option when lymphoma is suspected or when inconclusive results of previous fine needle aspiration cytology or core needle biopsy are obtained. The incidence of malignant lymphadenopathy varies with its location and the various diagnostic strategies. In metastatic lymphadenopathy of unknown primary origin, European Society for Medical Oncology (ESMO) guidelines and modern methods like next-generation sequencing (NGS) may help to manage such complex cases.
Dispensed drugs during pregnancy in outpatient care between 2015 and 2021 in Switzerland: a retrospective analysis of Swiss healthcare claims data
Authors: Marxer Carole A. , Graber Sereina M. , Surbek Daniel , Panchaud Alice , Meier Christoph R. , Spoendlin Julia
Published: August 2024

AIM OF THE STUDY: We aimed to evaluate the utilisation of all prescribed drugs during pregnancy dispensed in outpatient care in Switzerland between 2015 and 2021.
METHODS: We conducted a descriptive study using the Swiss Helsana claims database (2015-2021). We established a cohort of pregnancies by identifying deliveries and estimating the date of the last menstrual period. We analysed the drug burden during a 270-day pre-pregnancy period, during pregnancy (overall and by trimester), and during a 270-day postpartum period. Subsequently, we quantified 1) the median number of drug dispensations (total vs. unique drug claims); and 2) the prevalence of exposure to at least one dispensed drug and the number of dispensed drugs (0, 1, 2, 3, 4, and ≥5); and 3) the 15 most frequently dispensed drugs were identified during each period, overall and stratified by maternal age.
RESULTS: Among 34,584 pregnant women (5.6% of all successful pregnancies in Switzerland), 87.5% claimed at least one drug (not including vitamins, supplements, and vaccines), and 33.3% claimed at least five drugs during pregnancy. During trimester 1 alone, 8.2% of women claimed at least five distinct drugs. The proportion of women who claimed prescribed drugs was lower pre-pregnancy (69.1%) and similar postpartum (85.6%) when compared to during pregnancy (87.5%). The most frequently claimed drugs during pregnancy were meaningfully different during pregnancy than before and after.
CONCLUSIONS: This study suggests that 8 of 10 women in Switzerland are exposed to prescribed drugs during pregnancy. Most drugs dispensed during pregnancy are comparatively well investigated and are considered safe. However, the high drug burden in this vulnerable patient population underlines the importance of evidence on the benefit-risk profile of individual drugs taken during pregnancy.
It has been 30 years since the first alcohol septal ablation for hypertrophic obstructive cardiomyopathy was performed
Authors: Veselka Josef
Published: August 2024

No abstract available.
Severe Neuropathic Back Pain as the Initial Presentation in Angiostrongylus cantonensis Infection: The Role of ICU Management in Overcoming Diagnostic and Analgosedation Challenges
Authors: Nindya Auerkari Aino , Sedono Rudyanto , Pryambodho Pryambodho
Published: August 2024

Introduction: Angiostrongylus cantonensis is a parasitic nematode that typically inhabits the pulmonary arteries of rats but can also reside in the central nervous systems of rats and mollusks. Humans can become infected with A. cantonensis by eating infected hosts or consuming contaminated food, especially if it is raw or undercooked. This infection can lead to various neurological symptoms, including neuropathic pain, which is often an early indication of the condition. In this report, we present a case in which the patient experienced neuropathic pain as the initial clinical manifestation of A. cantonensis infection. Case Presentation: We present a rare case of a 27-year-old female who required intensive care unit (ICU) monitoring due to heavy sedation after receiving high doses of sedative-analgesics for back pain. The patient reported experiencing severe, slow-progressing low back pain radiating to her arms and legs. The pain was described as sharp, tingling, and numbing, severely limiting her movements. To manage the pain, a combination of morphine, intermittent fentanyl, ketamine, dexmedetomidine, duloxetine, and pregabalin was administered. Consequently, the patient had to be intubated due to the effects of the analgesics. During the first two weeks in the ICU, diagnosis proved challenging as the MRI was normal and the initial lumbar puncture revealed only an eosinophilic infection. However, during a follow-up lumbar puncture, multiple parasites were discovered in the cerebrospinal fluid, which were identified as A. cantonensis. The patient remains on a ventilator as the infection has affected the spinal nerve roots, cord, meninges, and brain. We explore the crucial role of ICU care in providing both supportive and definitive treatment for this patient. Conclusions: This report underscores the critical role of the ICU in providing care for a patient with a progressively deteriorating condition without an initial definitive diagnosis. The ICU's ability to deliver optimal pain relief and sedation, advanced monitoring, and prompt therapy for deteriorating symptoms was of utmost significance. Furthermore, the multidisciplinary team in the ICU was instrumental in managing the continuum of care for the patient.
Construction of CeRNA Regulatory Network Based on WGCNA to Reveal Potential Prognostic Biomarkers for AML Cancer
Authors: Larki Ard Darabi Fateme , Dehdar Mahsa , Azizi-Tabesh Ghasem
Published: August 2024

Background: Acute myeloid leukemia (AML) is a type of blood cancer with diverse genetic pathogenesis. The identification of potential molecular biomarkers could improve the AML diagnosis and targeted therapy. Recently, competing endogenous RNAs (ceRNAs) became an active area in cancer research to determine molecular mechanisms underlying tumor development. Objectives: The aim of the present study was to investigate the key molecular biomarkers that are closely related to AML through bioinformatics analysis. Methods: In this research, the RNA-seq data of 151 AML patients and 151 corresponding health samples were retrieved from The Cancer Genome Atlas (TCGA) database and GTEx Portal (genotype-tissue expression), respectively. After that we screened the differentially expressed long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and mRNAs by “limma” package in R to construct the co-expression network ceRNA (miRNA-lncRNA-mRNA) with weighted gene co-expression network analysis (WGCNA) package in R and Cytoscape (version 3.7.2) software, respectively. Then the relevant modules were identified and functional enrichment analysis was used to uncover the modules that are biologically related to AML cancer. Results: Based on our bioinformatics studies, we constructed a significant module which contain 333 genes. Among them, five up-regulated miRNAs with the highest GS (gene significant), include hsa-miR-374B, hsa-miR-553, hsa-miR-3679, hsa-miR-548L, hsa-miR-597 and five down-regulated miRNAs with the lowest GS including hsa-miR-3934, hsa-miR-4746, hsa-miR-466, hsa-miR-6722, hsa-miR-4490. For protein-coding genes (PCGs), the top-five up-regulated PCGs with the highest GS were AMIGO3, H2AC17, SPACA5, GPR21, and OR13C3. The top-five down-regulated PCGs with the lowest GS were XBP1, TOMM6, TREX1, TNFRSF6B, and BOLA2. Among the lncRNAs, the five up-regulated lncRNAs with the highest level of GS were GREP1, ZBTB20-AS2, LINC01596, LINC00345, and RMRP. The five down-regulated lncRNAs with the lowest GS were LINC01609, LINC01707, LINC02270, LINC02309, and LINC02243. These lncRNAs can serve as potential biomarkers to distinguish between AML and normal samples. Conclusions: Finally, considering the role of ceRNA network in various biological processes, examining the role of ceRNAs in AML may provide a deeper insight into molecular mechanisms underlying the pathogenesis of cancer. This understanding may propose potential biomarkers for diagnosis and therapeutic interventions.
Prediction and Course of Diastolic Dysfunction in COVID-19 Associated Pediatric Multisystem Inflammatory Syndrome
Authors: Ozyilmaz Isa , Yakut Kahraman , Yakut Nurhayat , Bekece Esma , Cansaran Tanıdır Ibrahim , Öztürk Erkut
Published: August 2024

Background: To predict the risk for diastolic dysfunction on admission and assess repetitive cardiac function during the follow-up of individuals diagnosed with multisystem inflammatory syndrome associated with COVID-19 (MIS-C). Methods: This prospective, single-center study comprises patients who were divided into two groups: Mitral E/e'≥8 and mitral E/e' < 8 on the first admission. During follow-up, patients underwent repeated echocardiography (on the first admission and at 1 week, 1 month, and 3 months post-procedure) between December 2020 and June 2022. Results: Among the 92 patients included in this study, 32 are females. Procalcitonin, erythrocyte sedimentation rate, B-type natriuretic peptide (proBNP), ferritin, and interleukin-6 (IL-6) values were found to be significantly higher in the E/e' ≥ 8 groups than that in the mitral valve E/e' 70.3, proBNP of > 278.5, and procalcitonin of > 2.4 was identified as an effective cut-off point in the mitral E/e’(> 8) for patients with MIS-C area under the curve (AUC) = 0.743, 95% confidence interval (CI) = 0.599 - 0.887, P = 0.005, sensitivity: 72%, specificity: 74% for IL-6; AUC = 0.680, 95% CI = 0.535 - 0.825, P = 0.037, sensitivity: 72%, specificity: 60% for proBNP; and AUC = 0.672, 95% CI = 0.528 - 0.816, P = 0.046, sensitivity: 72%, specificity: 60% for procalcitonin). Conclusions: Tissue Doppler imaging findings of diastolic dysfunction seem to be improved until the third month. Tissue Doppler imaging findings of diastolic dysfunction appear to ameliorate until the third month. Mitral valve E/e’> 8 value is significantly associated with IL-6, proBNP, and procalcitonin values in patients with MIS-C. IL-6, proBNP, and procalcitonin values were determined as independent high-risk indicators for left ventricular diastolic dysfunction.
Association Between Bladder Cancer and Environmental Risk Factors in Guilan Province: A Case-Control Study
Authors: Amoie Foumani Orchideh , Asri Yasaman , Atarchi Mir saeed , Esmaeili Samaneh , Shahrokhi Damavand Reza , Sadeghi Gholamreza , Kazemnezhad Leyli Ehsan , Marefati Majid
Published: August 2024

Background: Occupational settings expose workers to various substances linked to cancer risk, influenced by exposure intensity and duration. Considering the diverse work conditions across Iranian cities and the unexplored link between occupation and bladder cancer (BC) in Guilan Province, identifying high-risk occupations and industries is imperative for implementing preventive measures in the region. Objectives: To investigate the effect of people's occupations on bladder cancer in Guilan Province. Methods: The study encompassed 266 diagnosed BC patients in Guilan Province who received treatment at local healthcare centers, along with 191 control individuals aged 18 and over. Data for the cases were meticulously recorded in medical records at the Guilan Cancer Registry. The same checklists, including demographic characteristics, comorbidities, addiction status, water consumption habits, environmental exposures, current and previous occupation, previous history of cancer, and family history of cancer, were recorded for the controls. Odds ratios and their 95% confidence intervals were estimated using adjusted logistic regression (LR). Results: The study found that the odds ratio of bladder cancer (BC) was 2.80 (95% CI: 1.26 - 6.21) for the age group 60 - 70 years and 18.2 (95% CI: 7.31 - 45.6) for individuals above 70 years. Rural dwelling increased the risk by 5.06-fold, while well water consumption and regular opium use amplified it by 6.12-fold and 2.58-fold, respectively. Exposure to tar and carbon derivatives led to a 3.53-fold increase in risk, and exposure to combustion/greenhouse gases showed a 10.72-fold increase. Chemical-related occupations, tar, carbon derivatives, smoking, and opium consumption were significant risk factors. Conclusions: Occupations involving chemical substances such as greenhouse gases, tar, and carbon derivatives are associated with a higher risk of bladder cancer (BC). Furthermore, smoking, opium use, and well water consumption significantly elevate the risk of this cancer.
The Relationship Between Motivational Regulations and Intention to Continue Sport in Injured Athletes
Authors: Behzadnia Behzad , Fazeli Haniyeh , Rezaei Fahimeh , Moazam Saleh
Published: August 2024

Background: Injured athletes are prone to quit sports due to several factors, including changes in motivational regulations, and their intention to continue in sport comes with special challenges. Objectives: Based on the self-determination theory (SDT), we investigated the relationship between motivational regulations and intention to continue sport in athletes with a history of injury. Methods: One hundred twenty-one injured athletes (M age = 24.68, SD = 7.74) participated in this study and filled out a multi-section questionnaire. Results: Path analysis showed that injured athletes’ introjected regulation positively predicted their intention to continue in sport (path coefficient = 0.30). Conclusions: Findings showed that introjected regulation would consider as impornat criteria in persitising sport in athletes after experiencing injury.
Keniscayaan Merintis Program Kreatif Produktif Di Usia Tua Desa Tegalsari Kecamatan Plered Kabupaten Cirebon
Authors: Lela Citra , Vidiati Cory , Kharimah Kharimah , Hilmi Mamba’atul , Anindya Meyfa Dwi Hana , Muzdhalifah Muzdhalifah
Published: August 2024

This paper was prepared as a contribution from KPM students of Bunga Bangsa Islamic University Cirebon who are concerned about the welfare of elderly. The paradigm that the elderly population is not economically productive and often suffers from various diseases has become a special concern for students in community service programs. Various activities are carried out to stimulate the fine and gross motor skills of the elderly, which at the same time proves that they need attention and appreciation from society, family, and the state. The implications of this community service program are very positive for the elderly in Tegalsari Village, Plered District, Cirebon Regency. Although there are time constraints in program implementation, this can be overcome by creating successor cadres. overcome by creating successor cadres who are able to continue the program. Thus, the benefits can be felt sustainably by the elderly community in the village. Students hope that this effort will not only improve the welfare of the elderly but also build community awareness of the importance of their role and support. Through this service, it is hoped that a society that cares more and appreciates the existence of the elderly as an important part of the community will be realized
Information Literacy Among Users of Selected Children's Library in Nigeria
Authors: Mesagan, Olanike Faith
Published: August 2024

Information literacy among children in the contemporary world has bring about the need to investigate the importance of children libraries in acquiring literacy among library users. The study investigated information literacy skills for effective information resource utilization among users of Children Center Library, University of Nigeria Nsukka. The study used qualitative study design, data was collected using focus group discussion. Content analysis was use for data analysis. Instrument was validated by three (3) experts (two from Department of Library and Information and one from measurement and evaluation unit of the Department of Science Education), University of Nigeria, Nsukka. Findings revealed that children in CCL lacks the ability to recognize the needed information, to search and locate needed materials on catalogues. It also revealed that important skills are needed by the children. The extent of application of information literacy skills among the children is on the average. The barriers to information literacy among the users includes lack of access to information sources in the center library, limited parental involvement, information overload, peer pressure, spending much time on television, poor knowledge of librarians, fear of rejection among mates, language barriers, etc. Solutions include provision of unlimited access to information sources, parents assisting their kids at home, adequate training of librarians, good relationship between the children and staff, giving children sufficient time in the library and language tutoring among others.
Impact of Nutrition on Mental Health and Wellbeing of Primary School Children in a rural suburb of Enugu State, Nigeria
Authors: Osita Victor Ossai
Published: August 2024

The purpose of this study was to investigate the impact of nutrition on mental health and wellbeing in a rural suburb of Nigeria among primary school children. The study was conducted using an ex post facto design. Using a multi stage and random sampling procedure, 197 primary school children were selected from five migrant farmers schools in a rural suburb in Nigeria.  The researcher adapted two instruments: Children’s Mental Health Questionnaire (CMHQ) and Children’s Wellbeing Index (CWI). The Children’s Mental Health Questionnaire (CMHQ) is a 15-item questionnaire which measures the children’s level of depression, anxiety, suicidal thoughts and behaviour. Also, the Children’s Well-being Index (CWI) measures six dimensions of wellbeing such as self-acceptance, life satisfaction, personal growth, positive inter-personal relations, adaptability, and quality of life. The results showed that nutrition significantly impacted on the mental health of primary school children (β = .915; t = 31.1771; p-value = 0.000). Furthermore, the results showed that nutrition significantly impacted the well-being of primary school children (β = .949; t = 42.014; p-value = 0.000). It is recommended that interventions targeted at alleviating the plights of these vulnerable children should be a top priority for the government and non-governmental organizations.   It is also further recommended that laudable government programmes such as ‘school feeding programme’ in Nigeria should be revitalized to supplement the diets of school children who are exposed to malnutrition.
EFEKTIVITAS KOMUNIKASI ASERTIF DALAM MENINGKATKAN KETERAMPILAN PENGELOLAAN KEUANGAN MAHASISWA MELALUI PELATIHAN FINANCIAL LIFE SKILL
Authors: Wahyu Utomo Raden , Yusuf Ramayani , Hatimatunnisani Hani
Published: August 2024

Penelitian ini bertujuan untuk mengevaluasi efektivitas integrasi komunikasi asertif dalam pelatihan financial life skill terhadap peningkatan keterampilan pengelolaan keuangan mahasiswa. Di tengah kompleksitas ekonomi yang semakin meningkat, keterampilan pengelolaan keuangan menjadi sangat penting bagi mahasiswa, namun sering kali kurang mendapat perhatian dalam kurikulum pendidikan tinggi. Studi ini menggabungkan elemen komunikasi asertif ke dalam program pelatihan keuangan konvensional untuk menilai dampaknya terhadap pemahaman dan penerapan konsep keuangan oleh mahasiswa. Metode penelitian menggunakan desain eksperimental dengan kelompok pelatihan mahasiswa pada modul Komunikasi Asertif pada serangkaian kegiatan pelatihan Financial Life Skills.  Hasil penelitian menunjukkan peningkatan signifikan dalam keterampilan berkomunikasi mahasiswa. Temuan ini menggarisbawahi pentingnya mengintegrasikan komunikasi asertif ke dalam pelatihan Financial Life Skills untuk mahasiswa. Implikasi dari penelitian ini mencakup rekomendasi untuk merevisi kurikulum pendidikan keuangan di perguruan tinggi dan pengembangan program pelatihan yang lebih komprehensif yang menggabungkan keterampilan teknis dan komunikasi.
Father's Attitude In Breastfeeding Support: Literatur Riview
Authors: Syamsuri Prasida Yunita
Published: August 2024

This study aimed to determine the attitudes of fathers in breastfeeding support. Through the application of inclusion and exclusion criteria, this study was a literature review from the last five years, 2019-2024. PubMed and Google Scholar databases were used as data sources, and the publish or perish tool was used to search for publications using the keywords breastfeeding, father support, and father attitudes. An example of a study protocol used by researchers is the Preferred Reporting Items for PRISMA technique. This was a literature review study that used search strategies and inclusion and exclusion criteria. A total of 391 articles were retrieved from PubMed and Google Scholar databases after duplicate records were removed. The selection process involved evaluating the title and abstract, study design, population, and outcomes. Full texts of some articles were accessible. Ultimately, this review contains ten studies. Fathers' attitudes in supporting breastfeeding have a major impact on the achievement of breastfeeding success
Under-reporting Tuberculosis Cases At Private Health Sector: A Scoping Review
Authors: Suryanti Suryanti , Ahmed Idris Adewale
Published: August 2024

Tuberculosis (TB) remains a formidable threat to human civilization, with several factors contributing to its increasing burden. Challenges such as inconsistent case finding and diagnosis procedures, inadequate reporting, under diagnosing, unreliable drug supply, and substandard monitoring and recording practices collectively exacerbate the problems associated with TB. A major hurdle in effective TB control, especially in high-incidence countries where the private sector is heavily involved, is the significant underreporting of cases. To learn more about under reporting at private health sector, we conducted this scoping review. We screening articles related to under reporting at private health sector in PubMed, Google Scholars, and Science Direct electronic database. We included 36 studies of 95 screened records, of which observational (26), experimental (9), and qualitative (4) studies. Under reporting is influenced by various factors, including patient characteristics (such as being male, pediatric, or over 65 years old), health worker’s issues (unqualified or overworked personnel, staff shortages, lack of awareness, and insufficient incentives), and health systems (poor supervision, accountability, and a lack of support for hospital notification systems or complex health information management systems). Addressing these multifaceted issues is crucial for improving TB control efforts worldwide.
The Development And Validity Of A Mobile Application For Preventing 30 Days Re-Admission Among Heart Failure Patients
Authors: Amalia Irma Nur
Published: August 2024

Objective: To create and validate the expert validity evidence and content of a prototype mobile application for preventing 30 days readmission among heart failure patients. Method: Examination of technology advancement from the perspective of contextualized instructional design. During the analysis phase, five patients participated in a qualitative study and scope review to determine the content that would be included in the application. In the validation stage, cardiologist, specialist nurses and IT expert evaluated the content through face validity assessment. Data were analyzed using descriptive statistics. Results: The prototype of the application, called “Tele-Heart Nursing Care” has an interface and free navigation screens covering the Daily Monitoring for heart failure patients include Vital sign and Sign-Symptom monitoring, adherence of diet, exercise and medication. The app also features an educational guide, resources for early recognition of clinical signs, do's and don'ts to prevent the risk of relapse. The consultation feature is also available in a wide selection of themes for patients to choose from. Both the target audience and experts found the technology to be sufficient. Conclusion: It was feasible to create and verify the look and content of the “Tele-Heart Nursing Care” application prototype, which demonstrates the potential to promote self-care in people with heart failure