bluuebunny/crossref_metadata_2025 huggingface dataset:
Kajian Perkembangan Industri Buku Cerita Anak Bergambar di Indonesia pada Era Digital
Authors: Lutfiputri Nadia Farah
Published: December 2022

Perkembangan teknologi di era digital turut memberikan pengaruh ke perkembangan buku cerita bergambar. Studi ini bertujuan untuk melihat perkembangan buku cerita anak bergambar di Indonesia pada era digital, terutama terkait dengan pengaplikasian konsep hypermedia (penggabungan berbagai format media), interaktivitas (interaksi antara pembaca dengan teks atau media baca), dan gamifikasi (pengaplikasian elemen dan prinsip gim dalam teks bacaan). Dengan melakukan kajian secara desk research dan wawancara dengan orang tua, temuan studi ini menunjukkan bahwa sudah semakin banyak buku cerita anak bergambar yang hadir dalam format digital di Indonesia, terutama e-book. Selain itu, sudah mulai bermunculan juga aplikasi buku yang dilengkapi dengan elemen hypermedia, interaktivitas, dan gamifikasi. Meskipun demikian, orang tua masih cenderung memilih buku berformat fisik daripada digital untuk anaknya. Alasannya adalah walaupun kehadiran buku berformat digital telah menawarkan sejumlah kelebihan, namun sifatnya masih menjadi pelengkap atau alternatif, alih-alih menggantikan keberadaan buku fisik secara sepenuhnya.
Media Digital Menstimulasi Keterampilan Numerasi Anak Usia Dini di Lembaga PAUD
Authors: Maghfirah Febry , Satriana Malpaleni , Sagita Antung Dewi Nurliana , Haryani Wiwik , Jafar Farny Sutriany , Yindayati Yindayati , Norhafifah Norhafifah
Published: December 2022

Keterampilan numerasi anak usia dini sangat penting distimulasi untuk mengembangkan pengetahuan dan keterampilan peserta didik dalam menginterpretasikan angka dan keterampilan operasi bilang dalam kehidupan sehari-hari. Penelitian bertujuan untuk mengungkap efektivitas media digital dalam menstimulasi keterampilan numerasi khususnya pengetahuan angka dan keterampilan operasi bilangan anak usia dini di Lembaga PAUD. Penelitian menggunakan metode kualitatif dengan pendekatan studi kasus. Partisipan dalam penelitian ini yaitu 25 guru PAUD dari 15 lembaga PAUD yang ada di wilayah Pulau Kalimantan. Penelitian ini menggunakan wawancara dan dokumentasi. Hasil penelitian menunjukkan bahwa media digital yang mencakup berbagai elemen media seperti teks, gambar, audio, video, dan animasi efektif dalam menstimulasi keterampilan numerasi anak khususnya dalam pengetahuan angka dan operasi bilangan. Impikasi pada penelitian ini adalah media digital efektif dalam menstimulasi keterampilan numerasi khusunya dalam pengetahuan angka dan keterampilan operasi bilangan anak usia dini di lembaga PAUD.
Hadith Learning Strategies in Early Childhood Education
Authors: Rofiki Moh. , Nadrah Nadrah , Hasanudin Cahyo , Suttrisno Suttrisno , Ananda Rizki , Siahaan Kevin William Andri
Published: December 2022

There are two schools that carry out hadith learning in PAUD, namely PAUD RA Al Falah and PAUD Barokah in Pematangsiantar City. The Hadith learning education program delivered at RA Al Falah PAUD aims to shape and mold the personality of early childhood based on Faith and Piety, while the Hadith learning education program delivered at Barokah PAUD aims to form a generation with the character of the Prophet who has noble and noble character. character building. The purpose of this study was to determine learning strategies in PAUD. This study uses a descriptive qualitative approach with a multi-site design with data collection through interviews, observation and documentation. These stages include reduction, presentation and conclusion with research conducted on the RA Al Falah Al-Qur'an PAUD Program and the Barokah PAUD Program in Pematangsiantar City. The results of the research obtained by the RA Al Falah Qur'an PAUD Program and the Barokah PAUD Program Pematangsiantar City were the implementation of hadith learning strategies every day after reading prayers, reading Asmaul Husna, short suras. The conclusion of this research is the implementation strategy of developing aspects of child development through hadith learning, which is carried out classically and individually has been considered successful; its implementation is considered successful, and the results are also very good because friendly character education in all its aspects has improved significantly.
Determinan Faktor Orang Tua Millenial dalam Pendidikan Anak Usia Dini
Authors: Darojah Rani , Wijayanti Urip Tri , Sugiharti Sri
Published: December 2022

Generasi millennial dibesarkan dalam lingkungan masifnya penggunaan teknologi informasi, sangat bergantung pada internet yang mengakses seluruh informasi termasuk pendidikan anak usia dini (PAUD). Keberadaan lembaga PAUD tersebar diberbagai daerah. Namun, 37,4% orang tua milenial di provinsi Jawa Tengah tidak berpartisipasi menyekolahkan anaknya di PAUD. Tujuan penelitian, mengetahui determinan faktor orang tua millennial dalam pendidikan anak usia dini di provinsi Jawa Tengah. Jenis penelitian kuantitatif desain belah lintang. Respondennya  orang tua milenial dan memiliki anak usia pra sekolah. Jumlah responden 1448 orang. Analisis secara univariat dan bivariate menggunakan uji statistik chi square tingkat signifikansi 5%. Hasil penelitian menunjukkan, orang tua millennial yang tinggal di perdesaan, berpendidikan tinggi dan bekerja belum banyak berpartisipasi menyekolahkan anaknya di PAUD. Untuk itu penelitian ini diharapkan bermanfaat bagi Dinas Pendidikan untuk semakin meningkatkan sosialisasi dan publikasi pentingnya PAUD pada para orang tua yang bertempat tinggal di perdesaan dengan tingkat pendidikan tinggi dan bekerja, sehingga mereka tergerak berpartisipasi mengikutkan anaknya di PAUD.
Implementation of Augmented Reality (AR) as A Teaching Media in English Language Learning in Elementary School
Authors: Shaumiwaty Shaumiwaty , Fatmawati Endang , Sari Heni Novita , Vanda Yoiceta , Herman Herman
Published: December 2022

This study discussed the application of augmented reality as a medium of learning in English subjects in elementary schools. This study used multimodal analysis. The theory used is Multimodal by Kress and Leeuwen. The object of this research was a teacher who teaches English subjects in elementary schools. The location of this research is at one Elementary school in Medan city. In data collection used nonverbal data in the form of images, assisted by recording techniques, with the method of listening. The data collection instrument used a questionnaire, and an interview sheet. The results of this study are teachers are able to use Augmented Reality-based learning media in learning English well. Hence, there is an increase in student learning outcomes in English subjects after using Augmented Reality-based learning media. Based on the data obtained, it can be concluded that there is an increase in student learning outcomes before and after use which is obtained through the results of the pre-test and post-test, and teachers and students feel more fun in learning seen from the results of filling out the questionnaire which is carried out to obtain a score that is categorized as very good
Pengembangan Media Pembelajaran Anak Usia Dini berbasis Augmented Reality
Authors: Nasution Nurliana , Darmayunata Yuvi , Wahyuni Sri
Published: December 2022

Mengoptimalkan kegunaan smartphone khususnya bagi anak usia dini adalah penerapan teknologi Augmented Reality, yaitu teknologi yang menggabungkan objek dunia maya dengan dunia nyata secara realtime. Adapun tujuan penelitian adalah tersusunnya sebuah media berbasis Augmented Reality yang dapat diterapkan di lembaga pendidikan anak usia dini dan melihat peningkatan pemahaman guru mengenai penggunaan augmented reality. Penelitian ini menggunakan metode pengembangan dengan tahapan penelitian Analysis, Desain, Development, Implementation dan Evaluation. Subjek penelitian adalah guru pada TK Madani Cendekia Rumbai. Adapun hasil penelitian yaitu tersusunnya media pembelajaran berbasis augmented reality dan terjadi peningkatan pengetahuan dan pemahaman guru setelah dilakukan ujicoba kurikulum berbasis augmented reality pada subjek penelitian yang telah dilakukan, terdapat peningkatan yang signifikan pengetahuan guru antara sebelum dengan sesudah mengikuti ujicoba model kurikulum berbasis augmented reality.
Implementasi Pembelajaran STEAM melalui Kegiatan Fun Cooking Sebagai Pembelajaran Abad 21
Authors: Agusniatih Andi , R. Sri Muliana
Published: December 2022

Permasalahan dalam penelitian ini yaitu adanya perbedaan perkembangan kognitif, motorik, bahasa, dan kreativitas seni anak dengan tahapan perkembangan anak karena kurangnya pemberian stimulasi baik dari guru maupun orang tua  untuk merangsang minat anak dalam belajar. Sehubungan dengan masalah tersebut, penelitian ini bertujuan mengimplementasikan metode STEAM (Science, Technology, Engineering, Art, dan Mathematics) melalui kegiatan fun cooking sebagai metode pembelajaran abad 21. Jenis penelitian ini yaitu kualitatif deskriptif dengan menggunakan metode analisis data dari Miles dan Huberman. Teknik pengumpulan data melalui observasi, wawancara, dan dokumentasi. Sampel dalam penelitian ini yaitu kelompok B TK Samporoa DWP yang berjumlah 15 anak  yang kurang mendapatkan stimulasi dari guru maupun orang tua . Hasil penelitian dari kegiatan fun cooking menggunakan metode STEAM menunjukkan adanya ketertarikan 14 dari 15 anak dalam proses belajar yang dapat merangsang perkembangan kognitif, motorik, bahasa, dan kreatifitas seni anak sehingga kesimpulan dari penelitian ini adalah metode STEAM dapat diaplikasikan sebagai alternatif metode pembelajaran abad 21.
Implementasi STEAM dalam Mengkonstruksi Kesetaraan Gender pada Anak Usia Dini
Authors: Rini Ratu Yustika , Mutaqin Moh Fikri Tanzil , Fajari Laksmi Evasufi Widi
Published: December 2022

Pendekatan Science Technology EngineeringArts Mathematics (STEAM) pada anak usia dini hadir dikarenakan adanya tuntutakn era revolusi Industi 4.0, yang mampu menstimulus skills abad 21. Namun dalam pengintegrasian bidang-bidang ilmu STEAM dengan kegiatan bermain anak masih ditemukan kesenjangan gender. Penelitian ini bertujuan mengkaji implementasi STEAM dalam mengkonstruksi kesetaraan gender pada anak usia dini. Metode penelitian yang digunakan adalah kualitatif dengan pendekatan studi kasus. Subjek penelitian ini adalah anak berusia 5-6 tahun sebanyak 17 anak, 2 guru dan kepala sekolah. Teknik pengambilan sampel yang digunakan adalah teknik purposive sampling. Pengumpulan data dilakukan dengan wawancara, observasi dan studi dokumentasi. Teknik analisis menggunakan tematik analisis dan memvalidasi ulangkan dengan teknik triangulasi. Hasil penelitian menunjukkan bahwa (1) implementasi STEAM di PAUD; serta (2) kegiatan STEAM dan proses konstruksi kesetaraan gender. Penelitian ini menyimpulkan bahwa implementasi STEAM merupakan praktik baik untuk mengkonstruksi kesetaraan gender pada anak usia dini.
Permainan Tradisional Engklek dalam Meningkatkan Motorik Kasar Anak Usia Dini
Authors: Darmawati Novia Budhiarini , Widyasari Choiriyah
Published: December 2022

Perkembangan fisik motorik menjadi faktor penting dalam perkembangan individu secara keselurahan, untuk itu guru mampu meningkatkan kemampuan motorik kasar anak dengan melakukan berbagai aktivitas yang bisa menstimulus dan mengembangkan kemampuan motorik kasar. Studi ini bertujuan guna mengungkap bagaimana peran permainan tradisional untuk meningkatkan kemampuan motorik kasar anak. Penelitian dilakukan dengan metode studi kasus secara kualitatif. Teknik pengumpulan datanya meliputi wawancara, observasi, dan dokumentasi. Proses analisis data meliputi beberapa tahapan yakni reduksi dan penyajian data, serta pengambilan kesimpulan. Hasil studi ini menyimpulkan ketarampilan motorik kasar anak usia dini bisa dikembangkan melalui permainan tradisional Engklek dengan terpenuhinya beberapa indikator yaitu anak mampu menjaga keseimbangan tubuh, dapat menjaga kekuatan tubuh saat bermain, dan dapat bermain dengan lincah.
Kearifan Lokal Lereng Sindoro-Sumbing dalam Membangun Profil Pancasila Anak Usia Dini
Authors: Erviana Yurita , Agus Faisal Vava Imam
Published: December 2022

Pembentukan karakter sejak usia dini dari lingkungan keluarga, masyarakat dan sekolah dengan diajarkan tradisi dan adat istiadat yang dijalankan oleh rakyat mengandung nilai kecerdasan, pengetahuan dan moral untuk membangun peradaban masyarakat kedepannya. Tujuan dari penelitian ini untuk melihat peran masyarakat dalam menanamkan nilai kearifan lokal untuk membentuk profil Pancasila AUD serta melihat dampaknya yang ditinjau Dari Prespektif Agama, Budaya Dan Abad-21. Penelitian ini menggunakan pendekatan Community Based Research (CBR) dalam empat tahap yaitu Laying Foundation, Planning, Information Gathering and Analysis, dan Acting on Finding. Penelitian menggunakan penggabungan metode kuantitatif dan kualitatif.  Analisis data secara kualitatif untuk mendeskripsikan hasil dari FGD, quisioner hasil wawancara dan observasi, analisis data kuantitatif untuk mendiskirpsikan hasil dari angket . Hasil penelitian ini adalah hasil wawancara, pengamatan dan dokumentasi menunjukan informasi adanya sinergitas antara pihak desa, Lembaga pendidikan dan orang tua serta masyarakat dalam pembiasaan nilai-nilai kearifan lokal untuk membentuk karakter anak sejak usia dini, sehingga membentuk profil Pancasila.
APE Tradisional: Penanaman Rasa Cinta Tanah Air Berbasis Etnomatematika pada Anak Usia Dini
Authors: Rahmawati Ida Yeni , Wahyudi Wahyudi , Cahyono Hadi , Fadlillah M.
Published: December 2022

Alat permainan edukatif (APE) tradisional salah satu alat yang digunakan untuk menumbuhkan rasa cinta tanah air pada anak usia dini. APE tradisional juga mengandung unsur matematika. Penelitian ini bertujuan untuk mendeskripsikan APE tradisional pada playground budaya dalam menanamkan rasa cinta tanah air berbasis etnomatematika. Etnomatematika sendiri merupakan pembaruan budaya dengan matematika. Penelitian ini merupakan penelitian deskriptif kualitatif dengan menggunakan teknik triangulasi sebagai teknik untuk mengetahui keabsahan data, guna mengunji kebenaran hasil penelitian tersebut. Hasil penelitian ini menunjukkan bahwa beberapa APE tradisional yang terdapat pada playground budaya yang telah dikembangkan di TK Negeri Pembina Ponorogo yang diantaranya APE egrang batok, dam-daman, bakiak, congklak, dan engklak memuat unsur etnomatematika. Unsur-unsur tersebut yang berkaitan dengan anak usia dini adalah konsep berhitung (penjumlahan dan pengurangan), bangun datar, bangun ruang, dan logika matematika. APE tradisional ini juga mampu menumbuhkan rasa cinta tanah air seperti adil, tolerasi, kerjasama, gotong royong yang menunjukkan suatu persatuan dan kesatuan dalam bernegara. Dengan ini, APE tradisional di Indonesia akan tetap terlestarikan
STEAM-Based Learning Media: Assisting in Developing Children’s Skills
Authors: Hasibuan Rachma , Fitri Ruqoyyah , Dewi Utari
Published: December 2022

STEAM is a learning approach combining science, technology, engineering, arts/creativity, and mathematics. STEAM is not only a part of group studies, but also holistically integrates multiple approaches to solve problem. This research is a type of developmental research that aims to create a STEAM-based learning media for early childhood education through the ADDIE model. The data were collected from through one-group pretest-posttest design and analyzed according to the ADDIE developmental research technique. Participants of this research were young children aged 4-6 years who attended preschool and ECE teachers. The result shows that the developed media are proved to be valid in term of material and media feasibility. Moreover, it shows its practicality and effectiveness which comply with the standard use for early childhood education learning media; thus, it indicates that the developed media can be implemented as learning media for early childhood edu
Influence of Early Childhood Programs Literacy Movement on Students’ Interest and Reading Ability
Authors: Prasetia Indra , Lisnasari Srie Faizah , Gajah Nurhamidah , Karo Sekali Pelista Br , Rahman Arief Aulia
Published: December 2022

Minat dan kemampuan membaca permulaan siswa PAUD masih tergolong sangat rendah, terutama pada keterampilan membaca permulaan. Hal ini menunjukkan bahwa proses pendidikan pada program PAUD belum efektif dalam mengembangkan kompetensi dan minat siswa terhadap ilmu pengetahuan. Oleh karena itu, gerakan literasi sekolah dirasa sangat penting untuk dilaksanakan di sekolah sebagai salah satu cara dan upaya menumbuhkan minat dan keterampilan membaca permulaan siswa. Tujuan penelitian ini adalah untuk menganalisis pelaksanaan program literasi sekolah dan dampaknya terhadap minat dan kemampuan membaca permulaan siswa. Penelitian ini menggunakan pendekatan deskriptif kuantitatif dengan alat pengumpulan data berupa angket dan tes keterampilan membaca permulaan yang diberikan kepada siswa PAUD sebagai responden penelitian. Hasil penelitian menunjukkan bahwa pelaksanaan gerakan literasi sekolah berpengaruh terhadap minat dan kemampuan membaca permulaan siswa PAUD. Implikasi penelitian ini diharapkan menjadi evaluasi dalam mengatasi kesulitan membaca permulaan siswa
LncRNA HIF1A-AS1 Regulates the Cellular Function of HUVECs by Globally Regulating mRNA and miRNA Expression
Authors: Gong Zhiqiang , Yang Jin , Dong Junjie , Li Haotian , Wang Bing , Du Kaili , Zhang Chunqiang , Chen Lingqiang
Published: December 2022

Background: Long non-coding RNA (lncRNA) hypoxia inducible factor 1α-antisense RNA 1 (HIF1A-AS1) serves critical roles in cardiovascular diseases (CVDs). Vascular endothelial cells (VECs) are vulnerable to stimuli. Our previous study revealed that knockdown of HIF1A-AS1 reduces palmitic acid-induced apoptosis and promotes the proliferation of human VECs (HUVECs); however, the underlying mechanism remains unclear. Material and Methods: Cell Counting Kit-8, flow cytometry, transwell invasion, and wound healing were applied to detect the function of HUVECs. Moreover, miRNA sequencing (miRNA-seq) and RNA sequencing (RNA-seq) were conducted to uncover its underlying mechanism. Quantitative Polymerase Chain Reaction (qPCR) was implemented to assess the accuracy of miRNA-seq. A co-expression network was generated to determine the relationship between differentially expressed miRNAs (DEmiRNAs) and differentially expressed genes (DEGs). Results: Knockdown of HIF1A-AS1 promoted the proliferation, migration, and invasion but reduced the apoptosis of HUVECs, and the overexpression of this lncRNA had the opposite effect. Numerous DEmiRNAs and DEGs were identified, which might contribute to this phenomenon. Multiple target genes of DEmiRNAs were associated with cell proliferation and apoptosis, and overlapped with DEGs identified from RNA-seq. Finally, the network manifested that lncRNA HIF1A-AS1 moderated the function of HUVECs by not only regulating the expression of some genes directly but also by influencing a few miRNAs to indirectly mediate the expression of mRNAs. Conclusions: The results suggested that HIF1A-AS1 might regulate HUVEC function by not only regulating the expression of some genes directly but also by influencing some miRNAs to indirectly mediate the expression level of mRNA.
Development and implementation of a concept for substitution of the highly hazardous substances with safe chemical alternatives
Authors: Khamidulina Khalidia Kh. , Proskurina Angelina S. , Tarasova Elena V.
Published: December 2022

Introduction. The concept of chemical substitution is now increasingly included in policy and regulatory efforts around the world to reduce the risks of chemicals to human health and the environment, as well as in industry initiatives for the sustainable management of chemicals. With the exception of conventional substances regulated by EEC documents, unfortunately, there is no legislatively established mechanism for identifying, banning and limiting the production and consumption of highly hazardous chemical compounds in the Russian Federation. The purpose of the research is to develop and scientifically substantiate the concept of replacing highly hazardous chemicals with safer alternatives. Materials and methods. The guidelines and recommendations of the OECD, WHO, ILO, FAO, UNEP, as well as regulatory and methodological documents of the EU, the USA, Canada and other states on the criteria for classifying substances as highly hazardous, organizing and monitoring them in environmental objects and selection of safe chemical alternatives were studied and analyzed. Results. The concept of substitution includes the scientific substantiation of the criteria for classifying substances as highly hazardous, the organization and generalization of data from monitoring the human environment and the circulation of hazardous chemical products on the market, the development of a list of highly hazardous chemicals that are priority for regulation; selection of safe alternatives and their comparative analysis, taking into account the assessment of the advantages of the alternative over the existing technology/substance, implementation of management decisions. The criteria for identifying substances of highly concern and selecting their alternatives are the following indicators: biological activity (carcinogens, mutagens, reprotoxicants class 1A and 1B in accordance with GHS, endocrine disruptors); stability in the environment; bioaccumulative potential; the possibility of cross-media transfer; aquatic toxicity (acute and chronic toxicity of hazard class 1 in accordance with GHS); production volumes (volumes of emissions and discharges); number of contacts. Conclusion. The analysis of the international practice of regulating highly hazardous chemicals indicates the need to implement at the national level and within the framework of the Eurasian Economic Union a program for the systematic monitoring of high-risk chemicals circulating on the market in order to withdraw them from circulation and replace them with safe analogues. Implementation of the concept of replacing highly hazardous substances with safe chemical alternatives allows to create a draft national list of banned and restricted highly hazardous chemicals relevant to various industries (food, materials, basic chemistry).
Toxicological and hygienic study of imidourea as antibacterial preservative for pharmaceutical and cosmetic products
Authors: Golubeva Margarita I. , Bidevkina Marina V. , Sheina Natalia I. , Budanova Elena V. , Vinogradova Arina I. , Bobrineva Irina A. , Fedorova Emma A.
Published: December 2022

Introduction. Imidourea is widely used as an antibacterial preservative in the pharmaceutical and cosmetic industries. There are literature data on the toxicity and specific effect of the substance, but there are no hygienic standards in the air of the working area necessary to protect the health of workers. The study aims to substantiate the approximate safe level of exposure (ASLE) of imidourea in the air of the working area based on the study of the nature of biological action in various ways of entry into the body. Materials and methods. The researchers chose the methods for studying the functions of organs and systems of experimental animals after a single inhalation of the substance at concentrations of 35.3±5.7 mg/m3 and 6.1±1.7 mg/m3 taking into account the literature data on the biological effect of the compound under study. We studied the antimicrobial effect of the substance on the intestinal microbiota of rats after 24 hours and 144 hours after inhalation exposure. Results. During inhalation of the substance in both concentrations, the researchers observed disturbances in the balance of the intestinal microflora, which were characterized by changes in the number of individual representatives of the normal microbiota, which corresponds to the initial signs of dysbiosis of the 1st degree. 144 hours after exposure, the microflora balance was almost restored. Inhalation exposure to imidourea at a concentration of 35.3 mg /m3 also revealed changes in the functional parameters of the liver (decreased activity of alkaline phosphatase and glucose concentration in blood serum) and kidneys (decreased content and rate of protein excretion in urine). Conclusion. Imidourea in the inhalation route of admission has a general toxic, sensitizing, weak antimicrobial effect. We recommend to use the ASLE of imidourea in the air of the working area of 1.5 mg/m3 (aerosol). Ethics. The Ethics Commission of JSC "VNC BAS" adopted and approved the imidourea research program (Protocol No. 3 of 11.02.2020).
Parameters of spontaneous and benzene-induced cell death of spermatozoa under in vitro conditions in male employees of an oil production enterprise with impaired fertility
Authors: Alikina Inga N. , Dolgikh Oleg V.
Published: December 2022

Introduction. Every year there is a steady increase in the frequency of male infertility both in Russia and in other countries of the world with the concomitant low efficiency of recognizing the causes of its idiopathic forms. The explanation for the increase in infertility are: harmful production factors, including chemical ones, progressive deterioration of the quality of the urban environment, which has a significant impact on the reproductive health of the urbanized population, recurring economic crises that negatively affect the human psyche, mass consumption of substandard products and medicines. These factors, primarily chemical production, negatively affect the reproductive system, including the differentiation of male germ cells, as a cause of fertility disorders. The aim of the study to consider in vitro spontaneous and benzene-induced features of sperm apoptosis in male oil industry workers with impaired fertility. Materials and methods. We have conducted an experimental study of biological material (ejaculate) in 50 men with reproductive disorders (26-49 years old), employees of an oil production enterprise. To conduct the experiment in vitro, the researchers used seminal fluid samples. A benzene solution at a concentration of 0.001 micrograms/ml was used as an in vitro induction factor (selected experimentally). We divided the analyzed samples into 2 equal parts to study the spontaneous and benzene-induced expression of apoptosis markers (CD25+, CD95+, bax, p53, Annexin V-FITC and Propidium Iodide, Caspasa-3), which the researchers determined by flow cytometry. Results. There were no significant deviations of intracellular markers of sperm apoptosis (bax, p53, Annexin V-FITC+7AAD+, Annexin V-FITC+7AAD-, Caspasa-3), however, experts observed differences in the expression of CD95+ and CD25+ membrane proteins by 20% and 10% compared to the spontaneous level, which is associated with the acceleration of the events of programmed sperm death (p<0.05). Conclusion. The results obtained in an in vitro experiment on modeling the apoptosis program by induction with hapten (benzene) showed that violations of sperm cell death are associated with overexpression of the key receptor for triggering apoptosis CD95, as well as a marker of early activation of CD25 cells, which reflects benzene modification of the cell death scenario along the path of its excessive stimulation.
The relationship of electroencephalography (EEG) and neuroenergocarting indicators in vibration disease
Authors: Shevchenko Oksana I. , Katamanova Elena V. , Lakhman Oleg L.
Published: December 2022

Introduction. This article presents the results of a study of the relationship of phenomena characterizing the state of regulation of neurophysiological and energy processes in vibration disease (VD). The study aims to identify the relationships characterizing the state of regulation of neurophysiological and energy processes, according to the parameters of EEG and the level of constant potential (LCP) in patients with vibration disease. Materials and methods. We have examined thirty seven patients with VB caused by the combined effects of local and general vibration, thirty healthy men (comparison group). The researchers used electroencephalography and neurogenetic mapping techniques. Results. In the group of patients with VB, the nature of EEG activity was manifested by a change in the topical organization of the main normal EEG rhythms: the alpha rhythm, when compared with the comparison group, is more represented in the parietal leads (alpha rhythm index 30.7(15.8-53.5) and 45.3(34.9-59.5)% at p=0.010, respectively), beta1-rhythm - in a small, approximately the same amount, in all leads (in the right frontal from 3.7(2.8-5.6) and 6(3.8-8.2)% at p=0.020, in the left central leads up to 5.9(4.8-7.7) and 8.3(5.9-12.1)% at p=0.018, respectively). The delta rhythm index prevailed in the right frontal region 57.3(47.1-74.8) and 17(12-19)% at p=0.013, respectively. We have revealed a negative correlation of the delta rhythm index in the left frontal (Fp1), left central (C3), left parietal (P3), left occipital (O3), left temporal (T3) regions and LCP in the central (Cz) (r=-0.34; -0.32; -0.35; -0.39; -0.44; p=0.036; 0.048; 0.033; 0.016; 0.006, respectively). An increase in the theta rhythm index in the anterior frontal left lead (Fp1) can be associated with an increase in SCP in the occipital lobe of the right hemisphere (Pd-Ps, r=0.50; p=0.001). Limitations. Limitations are presented in the form of a small number of individuals in groups, insufficient depth of study of foreign literature materials on the issue under study. Conclusion. Interdependent disorders of neurofunctional activity in VB are: an increase in the theta rhythm index in the frontal, central regions of the left hemisphere with a right-hemisphere increase in neuroenergy exchange in the frontal, temporal, parietal regions; an increase in the delta rhythm index of the rhythm in the left hemisphere with a decrease in the LCP in the central parietal region. The strengthening of interhemispheric interaction with compensatory activation of the subdominant hemisphere is probably associated with the strain of adaptive potential, mechanisms for maintaining homeostasis, allowing to reduce neurological deficit by neuroplasticity.
MAKNA DAN BUDAYA OKO MAMA PADA KOMUNITAS UAB METO TIMOR TENGAH SELATAN
Authors: Nenoliu Rince Jefni
Published: December 2022

Dimensi dalam Ekolinguistik yang diaplikasikan untuk membedah maknabudaya oko mama dengan melihat parameter relasi yang diajukan oleh Haugen,Bangand Door dan kawan-kawan memberikan kejelasan akan makna, nilai dan fungsi okomama dalam kehidupan atoin meto secara faktual budaya, oko mama sangat adaptifdan respondik terhadap berbagai kalangan di kabupaten Timor Tengah Selatan. Halini merupakan salah satu nilai sosial yang dapat dimanfaatkan untuk mendorongperkembangan diri sebagai anak bangsa yang berkarakter.
Tenun Malakaa
Authors: Seran Aprilia Gresiani
Published: December 2022

Tais marobo Malaka adalah kain yang paling istimewa untuk kabupaten malaka
Budaya Kenoto Dan Perkawinan Adat Sabu
Authors: WILLA VIKTORIA SUSANA
Published: December 2022

Tradisi orang sabu merupakan suatu tradisi yang telah di wariskan oleh leluhur secara turun temurun yang harus di taati dan di hormati misalnya dalam pelaksanaan perkawinan adat orang sabu yang biasanya di lakukan saat melaksanakan perkawinan harus melalui suatu proses acara adat yang di sebut kenoto
Two and a Half Decades of Tahitian Noni Juice Research
Authors: West Brett
Published: December 2022

A review of Tahitian Noni Juice research since 1996 is presented and discussed.
Underestimated_Events_in_Silence_Research_Preprint
Authors: Dilba Dominik , Meyer Bertolt
Published: December 2022

Employee silence research stipulates that silence requires input to share, which we posit stems from encountering workplace events. We argue that the validity of relationships between employee silence and outcomes is limited without taking preceding events into account: Employees might not encounter relevant events and therefore cannot show silence. Further, workplace events can have independent effects on the outcomes attributed to silence, potentially confounding the effects of silence and preceding events. Drawing on an existing cross-cultural dataset (N = 8,222 in 35 samples), we show that some samples include up to 60% of participants who did not encounter relevant events. Using data from a German utility company (N = 572 in 129 teams), we demonstrate that the associations between employee silence and outcomes like burnout are overestimated if effects of events are left unaccounted. Lastly, a simulation study shows that biased silence-outcome relations are generalizable whenever events have independent effects on the outcome of interest.
MAKALAH Kritik Seni Musik Gereja Dan Hymne
Authors: Betty Andi
Published: December 2022

Musik gereja adalah bagian dari ibadah atau pelayanan di gereja. Setiap denominasi gereja mempunyai penataan musik gereja masing-masing sesuai dengan tradisi atau kebiasaan gereja tersebut. Gereja Sinta di Kuala Kapuas sebagai salah satu gereja yang cukup tua dari segi usia diharapkan menjadi barometer di tingkat lokal atau bahkan di tingkat regional Gereja Selama ini dalam perkembangannya musik gereja di Gereja Sinta telah diatur sedemikian rupa untuk meningkatkan kualitas bernyanyi dan kuantitas nyanyian jemaat yang dinyanyikan. Dalam penelitian ini penulis mencoba mengangkat permasalahan dan perkembangan musik gereja di Gereja Sinta Kuala Kapuas. Tujuannya untuk mendapatkan suatu gambaran umum sehingga nantinya diharapkan akan dilakukan solusi-solusi yang bersifat konstruktif untuk peningkatan kualitas dan kuantitas bernyanyi nyanyian jemaat. Dengan metode penelitian deskriptif kualitatif akan dipaparkan data penelitian dari hasil wawancara mendalam. Kesimpulan dari penelitian ini musik gereja di Gereja Sinta Kuala Kapuas telah berkembang cukup baik secara penataan dan diatur sedemikian rupa dalam bentuk latihan dan penjadwalan pada berita jemaat Minggu dan dilaksanakan oleh organis serta pemandu lagu.
KEARIFAN LOKAL UME KEBUBU
Authors: BORO NELLY RANGGA
Published: December 2022

Kearifan lokal dapat diartikan sebagai kemampuan suatu masyarakat untuk beradaptasi, mengatur, serta mengolah lingkungan alam dan budaya yang memengaruhi kehidupan mereka
The Dry Sky: Futures for Humanity’s Modification of the Atmospheric Water Cycle
Authors: Keys Patrick , Wang-Erlandsson Lan , Moore Michele-Lee , Pranindita Agnes , Stenzel Fabian , Varis Olli , Warrier Rekha , Wong R. Bin , D'Odorico Paolo , Folke Carl
Published: December 2022

Humanity is modifying the atmospheric water cycle, via land use, climate change, air pollution, and weather modification. Given the implications of this, we present a theoretical framing of atmospheric water as an economic good. Historically, atmospheric water was tacitly considered a ‘public good’ since it was neither actively consumed (rival) nor controlled (exclusive). However, given anthropogenic changes, atmospheric water is becoming 'common-pool’ (rival, non-excludable) or 'club’ (non-rival, excludable). Moreover, advancements in weather modification presage water becoming a 'private’ good (i.e. rival, excludable). In this research, we explore the implications of different economic goods framings using story-based scenarios of human modifications of the atmospheric water cycle. We blend computational text analysis with expert perspectives to create science fiction prototypes of the future. The economic goods framing highlights that social choices play an enormous role in how the future will unfold with regard to human interaction with the atmospheric water cycle. The narrative scenarios serve two purposes. First, they provide creative artifacts for the investigation of future interactions with the atmospheric water cycle, that are rooted in a scientific evidence base. Second, they articulate trajectories of our coupled social-hydrological world that require deeper interrogation and anticipation in the present.
Evaluation of a male-specific psychotherapeutic program for major depressive disorder compared to cognitive behavioral therapy and waitlist: Study protocol for a six-arm randomized clinical superiority trial examining depressed eugonadal and hypogonadal men receiving testosterone
Authors: Walther Andreas , Ehlert Ulrike , Schneeberger Michèle , Eggenberger Lukas , Flückiger Christoph , Komlenac Nikola , Heald Adrian , Rice Tim , Palm Simona , Seidler Zac E. , Ogrodniczuk John S. , Olive John , Rice Simon , Kealy David , Weber Rainer , Zimmermann David
Published: December 2022

Background: Treatment of major depressive disorder (MDD) in men is complicated by the endorsement of traditional masculinity ideologies (TMI) often leading to reluctance towards psychotherapy, therapy interfering processes, or premature termination. In addition, it has been shown that men with MDD have a significantly increased risk of being hypogonadal (e.g. total testosterone levels < 12.1nmol/l). Therefore, it is recommended to examine depressed men with regard to their testosterone status and if hypogonadism is present to combine psychotherapy with testosterone treatment (TT).Aim: This project aims to evaluate a male-specific psychotherapeutic program (MSPP) for MDD in depressed eugonadal and hypogonadal men receiving testosterone in comparison to a standard cognitive behavioral therapy (CBT) for MDD and a Waitlist.Methods: The study presents a 2x3 factorial study design. In total, 144 men aged between 25 and 50 will be stratified by testosterone status (eugonadal / hypogonadal) and then randomized into one of the three conditions (MSPP, CBT or Waitlist). Additionally, a healthy control group of 100 men will be recruited, which will undergo only baseline assessments. Both standardized psychotherapy programs will encompass 18 sessions delivered in a weekly manner. Aligned with the TT-related medical visits of the 72 hypogonadal men, all participants will be followed up with clinical assessments and bio sampling at weeks 0, 6, 15, 24, 36.Discussion: This study represents the first attempt to test a male-specific psychotherapy for MDD in a single-setting compared to standard CBT and a Waitlist control condition using randomized clinical trial methodology. In addition, the potential positive adjunct effect of psychotherapy to TT in reducing depressive burden and improving quality of life in hypogonadal depressed men represents a neglected research area and might introduce new hypogonadism screening procedures in depressed men and combined treatment approaches for depressed men suffering from hypogonadism. Limitations are the rigorous inclusion and exclusion criteria, which limit the generalizability of the study results to first episode treatment naïve depressed men.
Industrial embeddedness and regional economic resistance in Europe
Authors: Kitsos Tasos , Grabner Simone Maria , Incera Andre Carrascal
Published: December 2022

We study the role of local industrial embeddedness (the share of regional inter-industry economic activity that is anchored to a region) on regional resistance (the difference between pre- and post-crisis employment) to the 2008 Great Recession (GR) in EU and UK NUTS2 regions. The recession had profound effects in regional economies, which showed diverse performance based on their capacity to absorb the shock. The concept of economic resilience has been brought to the center of attention with several contributions exploring its determinants. However, the impact of the embeddedness of local economic systems in terms of sales and supplies has been largely unexplored. We use regional input-output tables to approximate the embeddedness of local economies between and, fixed-effects and quantile regressions to test its relationship to regional resistance between 2008 and 2011. We find that during the GR, regional industries opted to change input rather than output markets. Additionally, embeddedness has a curvilinear relationship to regional resistance which varies across the distribution of regional resistance performance. Finally, at the industry level we find regional embeddedness to be important to the resistance of manufacturing and financial and business services and sectoral embeddedness to matter more for the resistance of construction and wholesale, retail & IT. Our findings highlight nuances that policymakers should be aware of in planning for resilience.
Family Policies and Couples' Division of Housework Following Childbirth in Germany, 1994-2019
Authors: Zoch Gundula , Heyne Stefanie
Published: December 2022

We examine how the re-traditionalization effect of childbirth on couples’ division of housework has evolved over time as a result of major family policy change. Supportive family policies are associated with a more egalitarian division of labor. However, it remains unclear how a country’s transition from a modernized male breadwinner regime that supports maternal care to family policies that promote maternal employment and paternal caregiving change couples’ gender-typical division of housework in the long run. We use representative survey data from the GSOEP (1994 – 2019, N=14,752) and estimate the re-traditionalization effect of childbirth on mothers’ absolute and relative time-use on housework over 4 policy periods with linear fixed-effects regression models. Across all periods, mothers take on larger absolute and relative levels of housework after childbirth, with a more pronounced and persistent gender-typical division in West than in East Germany. However, mothers spend somewhat less absolute and relative time on housework in recent periods with stronger levels of de-familiarizing and dual-earner/dual-carer policies than in earlier periods with policies supporting maternal caregiving. We find somewhat smaller and less persistent re-traditionalization effects of childbirth in more supportive work-family policy periods. In sum, the small changes illustrate that even in contexts of enormous policy change, progress towards a less gender-typical division of housework has been slow and rather small.
Opportunity and Challenges of Interventional Cardiology
Authors: Karki D. B.
Published: December 2022

No abstract available.
Evaluation of the Diagnostic Potential of Liver Aminotransferases and Alkaline Phosphatase in Patients with Cardiovascular Diseases
Authors: Yadav N. K. , Pokharel D. R. , Kathayat G. , Sigdel M. , Hussain I.
Published: December 2022

Background Cardiovascular diseases (CVDs) are the major cause of morbidity and mortality, particularly in developing countries. Early diagnosis with the best diagnostic marker is highly desired for the prevention and timely treatment of CVDs. However, there is still a dearth of an ideal marker for the detection of CVDs.

Objective To explore the diagnostic potential of liver aminotransferases (AST and ALT), and alkaline phosphatase for the diagnosis of CVDs without liver involvement.

Method This was a cross-sectional study conducted among 200 adult patients with CVDs, who visited the cardiology and emergency units of Manipal Teaching Hospital, Pokhara, Nepal. The study was conducted from January 2018 to December 2020. The baseline data on family history, anthropometry, baseline biochemical parameters, liver enzymes, and cardiac biomarkers were collected using standard and validated methods. The data were analyzed using SPSS version 21 and MedCalc software 2021.

Result The diagnostic sensitivity of aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase were 53.7%, 52.6%, and 33.7% and specificity were 99%, 90%, and 90% respectively. The area under the curve (AUC) of AST, ALT, and ALP were 0.78, 0.73, and 0.52 respectively. ROC curve indicated that serum AST and ALT activity was a better reliable marker than the serum ALP activities.

Conclusion Our study suggests that serum aspartate aminotransferase and alanine aminotransferase but not alkaline phosphatase could have some diagnostic potential to diagnose the risk of CVDs. However, they could not replace the currently adopted cardiac biomarkers such as cTnI and CK-MB.
Oral Health Care Practice and Circumstances during Covid-19 among Dental Patients in Tertiary Care Hospital in Nepal
Authors: Prajapati D. , Hada B. , Ghimire G. , KC S. , Singh S. , Makaju S. , Mahanta S. K.
Published: December 2022

Background Patients are hesitant to enter a dental hospital because of the significant danger of cross infection and illness transmission due to rapid spread of corona virus.

Objective To assess knowledge regarding Covid-19, oral health practices and circumstances on dental treatment during a pandemic.

Method Cross sectional study was conducted among patients visiting dental department of Dhulikhel hospital from September to October 2020. Questionnaires were interviewed following safety protocols regarding the pandemic and descriptive analysis was performed. Both verbal and written consent as well as ethical approval was taken before the study.

Result A total 411 patients aged 14 to 75 years old from 14 different districts across Nepal participated in the study. All of the patient were free of Covid-19 symptoms and had strong knowledge and awareness about disease transmission. During the crisis 96% of the people maintain good oral hygiene while 25.8% acquire new dental problems where majority experienced oral discomfort and swelling, 93.2% of them did not attend a dental clinic or hospital in the interim owing to fear and inaccessibility. Majority of the participants were impressed by the safety precautions and preparations during treatment and 99.3% strongly suggest or pledge to visit dental department if necessary during the pandemic.

Conclusion Dental patient visiting Dhulikhel hospital is highly aware of current health crisis, possible transmission and preventive measures. Proper safe hospital setup can encourage them to seek dental treatment during crisis. Dental pain and swelling in Endodontic department recorded most common dental emergency during this pandemic.
Comparative Study of Common Bile Duct Diameter between Normal and Post Cholecystectomy Cases Using Trans-abdominal Ultrasonography
Authors: Paudel R. C. , Karki S. , Suwal S. , Palikhe A. , Mandal D. , Manandhar M.
Published: December 2022

Background Increase in common bile duct diameter can occur because of different causes. Post cholecystectomy status is one of the potential causes. Many studies done in the past show different results and are hence inconclusive.

Objective To see if the post cholecystectomy cases would have a statistically significant change in common bile duct diameter.

Method We carried out a study in 100 cases (46 post cholecystectomy cases and 54 cases with intact gall bladder, measuring their common bile duct diameters and performing an unpaired t test to see if the mean in common bile duct among these two groups of cases was statistically significant.

Result One hundred cases, 46 post cholecystectomy cases and 54 cases with intact gall bladder were included in our study. An unpaired t-test was used to compare the common bile duct diameters in these two groups. Our findings showed that the difference in common bile duct diameter between the cases with intact gall bladder and those who underwent cholecystectomy was significant for both one tailed and two tailed studies (p < 0.001). Hence, it can be stated that post cholecystectomy status increases the common bile duct diameter.

Conclusion An increased Common bile duct diameter in post cholecystectomy case could be because of the post cholecystectomy status itself and not due to some other obstructive cause. So careful decision is necessary before subjecting the patient to further invasive/non-invasive investigations and treatments.