bluuebunny/crossref_metadata_2025 huggingface dataset:
Learning abnormal physical examination signs: an introductory course
Authors: Sabirov Albert , Chludzinski Melodie , Eminof Emin , Eddy Alexis , Gallagher John , Jung Ichabod
Published: March 2023

Context

The acquisition of clinical skills is an essential part of the osteopathic medical school curriculum. Preclinical medical students, especially at osteopathic medical schools, have limited exposure to abnormal physical examination (PE) findings that are not typically seen in a student’s peers or in a standardized patient (SP). The early exposure of first-year medical students (MS1s) to normal and abnormal findings in the simulation settings better equips them to identify abnormalities when they encounter them in a clinical setting.

Objectives

The aim of this project was to develop and implement the introductory course on learning abnormal PE signs and pathophysiology of abnormal clinical findings to address the educational needs of MS1s.

Methods

The didactic part of the course consisted of PowerPoint presentations and lecture on the topics related to the simulation. The practical skill session was 60 min, during which time students first practiced PE signs and then were assessed on their ability to accurately identify abnormal PE signs on a high-fidelity (HF) mannequin. Faculty instructors guided students through clinical cases and challenged them with probing questions in clinically relevant content. Before- and after-simulation evaluations were created to assess students’ skills and confidence. Student satisfaction levels after the training course were also assessed.

Results

This study demonstrated significant improvements in five PE skills (p<0.0001) after the introductory course of abnormal PE clinical signs. The average score for five clinical skills increased from 63.1 to 88.74% (before to after simulation). The confidence of students in performing clinical skills and their understanding of the pathophysiology of abnormal clinical findings also increased significantly (p<0.0001) after simulation activity and educational instruction. The average confidence score increased from 3.3 to 4.5% (before to after simulation) on a 5-point Likert scale. Survey results demonstrated high satisfaction with the course among learners with mean satisfaction score 4.7 ± 0.4 on 5-point Likert scale. The introductory course was well received by MS1s and they left positive feedback.

Conclusions

This introductory course offered MS1s with novice PE skills the ability to learn a variety of abnormal PE signs, including heart murmurs and rhythms, lung sounds, measurement of blood pressure (BP), and palpation of the femoral pulse. This course also allowed abnormal PE findings to be taught in a time-efficient and faculty-resource–efficient manner.
Environmental effects of marble quarry operations in Burdur Lake Basin (Burdur-Turkey)
Authors: Ozcelik Mehmet
Published: April 2023

Marble is the most important natural material because of its structural features and its long durability. It is mined at operated quarries on hill slopes. The original landform is permanently altered, and vegetation cover is destroyed. Another important feature of marble quarries is the large amount of waste materials released during the quarrying process. In the last decades, together with the visible effects of global warming and climate change, fresh water resources are rapidly depleted and polluted due to careless land use. Quarrying operations are among the most important stakeholders of this process. Environmental effects of quarry activities depend on the location of the site in the landscape, the vertical and horizontal dimensions of the excavation, the methods used to excavate the marble, and the formation of the geological structure. Furthermore, the region's seismicity, microclimate conditions, ecological condition, and surface and groundwater conditions are all factors influencing environmental degradation. Additionally, numerous serious environmental impacts associated with quarrying activities near the site, such as visual pollution, water, dust, noise, air pollution, vibration, land subsidence, and landslides, will cause health issues and unpredictable biodiversity loss. Quarrying operations have the potential to impact pre-existing ecosystems, including groundwater depletion, loss of fertile topsoil, forest degradation, and human health. This article aims to draw attention to various serious environmental impacts, health problems and biodiversity loss resulting from quarrying operations in Burdur Lake Basin.
Development and application of modular bamboo-composite wall construction
Authors: Zhou Haiying , Sun Fengbo , Li Haidong , Zhang Wenfu , Cheng Haitao , Chen Linbi , Yu Zhiming , Chen Fuming , Wang Ge
Published: March 2023

The objective of this study was to design and develop a novel type of modular bamboo-composite wall using bamboo bundle veneer/wood veneer laminated composite (BLVL) with excellent physical and mechanical properties. The physical and mechanical properties of the important component of the bamboo-composite wall, BLVL, were characterized and the thermal insulation properties of three types of walls composed of different thickness of structural layers were studied. The results showed that the physical-mechanical properties of BLVL-composite walls were excellent. For BLVL wall panels, parallel and perpendicular to the glue layer, the static bending strength and elastic modulus were 137.8 MPa and 124.1 MPa vs. 1.37 GPa and 1.06 GPa, respectively. The internal bonding performance of BLVL was 3.07 MPa, 3 times greater than the standard requirement. The total heat transfer coefficients for models І and II of the bamboo-composite walls were 0.46 and 0.43 W/(m2·K), respectively, in line with the requirements of the “Public Building Energy Efficiency Design Standards” GB/T 50189-2005. The development of novel bamboo composite wall and its promotion and application in fabricated buildings have important market prospects and ecological and social values.
On the Security Analysis of Lee, Hwang & Lee (2004) and Song & Kim (2000) Key Exchange / Agreement Protocols
Authors: Choo Kim-Kwang Raymond
Published: March 2023

We revisit the password-based group key exchange protocol due to Lee et al. (2004), which carries a claimed proof of security in the Bresson et al. model under the intractability of the Decisional Diffie–Hellman problem (DDH) and Computational Diffie–Hellman (CDH) problem. We reveal a previously unpublished flaw in the protocol and its proof, whereby we demonstrate that the protocol violates the definition of security in the model. To provide a better insight into the protocol and proof failures, we present a fixed protocol. We hope our analysis will enable similar mistakes to be avoided in the future. We also revisit protocol 4 of Song and Kim (2000), and reveal a previously unpublished flaw in the protocol (i.e., a reflection attack).
Effect of Proton Pump Inhibitor Treatment in “PPI Non-responsive” Patients with Eosinophilic Esophagitis
Authors: Thakkar Kisan P , Philpott Hamish , Lafata Sean , Fowler Mark , Keene Staci , Iuga Alina , Dellon E.
Published: March 2023

Background and Aims: Some eosinophilic esophagitis (EoE) patients can have a decline in eosinophil count after proton pump inhibitor (PPI) treatment without achieving histologic response, but little is known about this group. We aimed to determine the effect of PPIs on reducing esophageal eosinophilia in patients deemed non-responsive to PPI therapy.

Methods: We analyzed prospectively collected cohort data from newly diagnosed adults with EoE who were histologic non-responders (≥15 eos/hpf) to PPI-only therapy. Symptoms, endoscopic histologic features were assessed before and after PPI. Pre- and post-PPI treatment esophageal biopsies were read by pathologists to determine peak eosinophil counts and other histologic findings.

Results: Of 125 patients, peak eosinophil counts were 102.1 ± 69.8 and 102.9 ± 101.1 (p=0.93) before and after PPI treatment, respectively, but lamina propria fibrosis decreased from 97% to 41% (p<0.001). Heartburn frequency also decreased (19% to 11%; p=0.006), though endoscopic findings did not change. There were 75 patients (60%) who had some decrease in eosinophil counts, with 30 patients (24%) having ≥50% decrease in counts. When comparing the ≥50% and <50% decrease groups, differences in endoscopic features were identified, but the ≥50% group had improvement in eosinophil degranulation, microabscesses, spongiosis, and basal cell hyperplasia.

Conclusion: Peak eosinophil counts did not decrease overall after PPI treatment, but symptoms of heartburn improved. Approximately a quarter had ≥50% decrease in eosinophil counts, with associated decreases in other histologic findings. Further research may consider what role PPIs have in this subset of non-responders or in combination therapies.
ARIMA model for COVID-19 and its prediction in India
Authors: Shukla Kamlesh Kumar , Rahman Syed Azizur , Singh Ranjana , Shanker Rama
Published: April 2023

In this paper, autoregressive integrated moving average (ARIMA) model has been applied to know the trend and to predict future pattern of present COVID-19 in India. Accuracy of the model has been checked. Data from July 1, 2020 to August 3, 2021 has been taken for the study. We estimated ARIMA model to forecast the epidemic trend over the period after July 1, 2020, by using the Indian epidemiological data (www.COVID19india.org)1 at national level. The data refer to the number of daily confirmed, total confirmed and deceased cases officially registered by the Indian Ministry of Health (https://api.COVID19india.org/) for the considered period. The main aim of this study is to know the trend of COVID-19 daily cases as well as deceased cases, and forecast for next 120days after August 3, using appropriate ARIMA model.
Isolated hepatomegaly became Her’s – a case report
Authors: Jose Priya , Ganesh Solai , A Anitha , Kumar Kommu Peter Prasanth
Published: April 2023

Glycogen storage diseases (GSDs) are a group of inherited metabolic disorders caused by mutations in one of the several enzymes involved in glycogen synthesis or breakdown. GSD VI is caused by mutations of PYGL gene encoding hepatic glycogen phosphorylase on chromosome 14q22.1, which has a major role in glycogen metabolism. We report a case of 2year old girl child presented with complaints of slowly progressive abdominal distention of one year duration. Abdominal examination revealed hepatomegaly (liver span 9cm). Lab investigations revealed mild anemia, hypertriglyceridemia and normal liver function. Liver biopsy showed marked elevation of glycogen content in liver with structurally normal glycogen which was consistent with GSD. Sanger sequencing done to identify the subtype of GSD showed PYGL gene mutation, pathogenic variant of type-VIGSD. In the case of isolated hepatomegaly, a glycogen storage disease must be considered in the differential diagnosis and Sanger sequencing must be done for confirmation and prognostication
Modern paradigms and megatrends of industrialdevelopment
Authors:   Institute of Idustrial Economy of NAS of Ukraine, Zbarazska Larysa
Published: April 2023

Implementation of long-term strategies by all industrial stakeholders. The global nature of the challenges necessitates the organic and harmonious integration of all national economies into a new paradigmatic development framework. This requires active rethinking of strategic concepts and industrial policies by political and economic elites at the national, regional, and global levels. There is a growing trend towards expanding the targeted multi-dimensionality of industrial development as a component of holistic socio-economic systems at any level. Thus, the task of deepening the balance and harmonization of individual vectors and processes, both in the sector itself and in related sectors of the economy, is becoming more urgent. As part of the implementation of the imperatives of the socio-humanitarian paradigm, megatrends are being formed to prioritize the inclusion of humanitarian progress goals in industrial strategies and policies, transition to customer-oriented business models, and reorientation of industrial activities to form/expand the "comfort zone" (in various dimensions). The trend of systemic changes in the models of production use of all types of resources on the basis of maximizing resources’ efficiency and environmental safety is strategically important for global industrial development. This will lead to a shift in emphasis in long-term strategies from maximizing the volume and quantity to optimizing the structural and quality parameters of industrial production. The prospects for implementing the innovative paradigm of industrial development will be mainly determined by the scale and dynamics of 4IR deployment in key technological areas (digitalization, robotics, Internet of Things, artificial intelligence, etc.). For sustainable and inclusive development permanent innovative adaptability to changes is becoming a necessary property of industrial production and economic systems at all levels. In the context of the technological trend caused by the 4IR, the factors of information and communication and human resources are becoming increasingly important. The implementation of the innovative paradigm of industrial development contributes to the dynamic formation and deployment of the trend of creativity in the development and modernization of business models and industrial projects. At the current stage of world industrial development, the implementation of the globalization paradigm is accompanied by contradictory phenomena. However, the economic effects of globalization, which have already manifested themselves or are potentially possible, provide grounds to consider the trends caused by it as relatively stable long-term trends. The current processes of national/regional autonomisation should be viewed as a tactical adaptation maneuver in the economic policy of states and regional entities.
Rotational inertia-based tuned-mass-damper for controlling force transmission
Authors: Barredo Eduardo , Mazón-Valadez Cuauhtémoc , Mendoza-Larios José Gabriel , Maldonado-Bravo Irving Abdiel
Published: March 2023

Nowadays, the inerter device has become one of most popular mechanical devices in the vibration absorption field for both stationary and non-stationary mechanical structures. One of the problems commonly reported in the literature is the force transmission control in the foundations that support the machines, which is generally addressed by using either isolators or classic dynamic vibration absorbers (DVAs). However, the mechanical energy dissipation capability of these two solutions is still limited. This work focuses on improving the control performance for the conventional absorber using the inerter’s inertial mass amplification and negative stiffness effects. In order to fairly evaluate the control performance of the DVA based on grounded inerter, the  and  optimization criteria are proposed. When the dimensionless frequency response function (FRF) of the transmissibility is minimized at the resonant peaks, the  criterion reveals an improvement of 29.74% in mitigating harmonic vibration. Finally, the total vibration energy transmitted to the foundation is minimized via  criterion that provides an improvement of 33.03%.
Behavior of a new laterally top-loaded post-grouted micropile in highly porous lateritic soil
Authors: Barbosa Yuri , Heryaldo Pinheiro Tarozzo Murilo , José Rocha de Albuquerque Paulo , De Carvalho David
Published: March 2023

The use of micropiles has been increasing in recent years, mostly for horizontally loaded cases. Given the little information about this foundation type under lateral top-loading, especially in high-porosity and collapsible soils, a total of four transversal loading tests were carried out in a new post-grouted micropile configuration with length of 17 m and diameter of 0.3 m, two in natural soil moisture conditions and two in flooded conditions. Load-displacement curves and the horizontal reaction coefficient of the new micropile were obtained. Results were compared with other pile types laterally tested under the same conditions and in the same geological and geotechnical contexts. Generally, results were better than the other pile types, mainly under saturated condition. The new micropile proved to be a better and more efficient alternative for local lateritic soil treatment when compared with the soil-cement treatment.
Calibration and validation of models to estimate the hydraulic parameters of a confined aquifer in a tropical region
Authors: Huguet-Sierra Gerardo Arturo , Márquez-Romance Adriana Mercedes , Guevara- Pérez Edilberto , Pérez-Pacheco Sergio Alejandro , Buroz-Castillo Eduardo
Published: March 2023

This article deals with the calibration and validation of models for water yield from a confined aquifer in a tropical region. From 2015 to 2019, 20 variable flow pumping tests were carried out. The average pumping flows varied between 0.07 and 17.4 L/s; the average drawdown of the water levels, between 5.99 and 50.94 m; the values of transmissivity and storage coefficient were lower than 77 m 2 /day and 6 x 10 -5, for probability of non-exceedance of 85%. In the calibration stage, the mean values of the coefficients of the proposed models a and b were in the order of 10 1 and 10 3. The determination coefficients obtained in the statistical adjustment of the proposed models are satisfactory, they varied between 76 and 85%. The validation stage revealed that the models need to be tested with a larger number of data.
Genotyping of rickettsias circulating in the territories of the Altai Republic and Khabarovsk krai
Authors: Shtrek Sergey V. , Rudakov Nikolay V. , Shpynov Stanislav N. , Sannikov Alexey V. , Samoylenko I. E. , Shchuchinova Liliya D. , Trotsenko Olga E. , Dragomeretskaya Anna G. , Matushchenko Elena V.
Published: April 2023

The aim of the study was to verificate of the causative agent of Siberian tick-borne typhus (STT) upon ixodic tick mixed infection on the territory of the Altai Republic and Khabarovsk Krai using an integrated molecular biological approach. Materials and methods. The material for the study was presented as 304 imago of ixodic mites of six species. The ticks were collected on the territory of the Altai Republic and the Khabarovsk Krai in the years 20142022. Rickettsia DNA was identified by two-round PCR using genus- and species-specific primers for gltA and ompA genes, followed by sequencing and using PCR reagent kits RealBest DNA R. sibirica/R. heilongjiangensis (Vector-Best, Novosibirsk). Results. The detection of rickettsia in ticks in the Altai Republic was 82.6% (CI: 69.196.1), in the Khabarovsk Krai 53.1% (CI: 44.961.3). The species composition of rickettsias in various species of ixodic mites in these territories, endemic to Siberian tick typhus, is characterized by the presence of mixed forms. Rickettsia sibirica and R. raoultii were found in ticks Dermacentor nuttalli, Haemaphysalis concinna, D. silvarum. Only Candidatus R. tarasevichiae were detected in Ixodes persulcatus, I. pavlovsky mites and I. pavlovsky/persulcatus hybrids. The DNA of R. heilongjiangensis was found in H. mites. concinna in the Khabarovsk Krai. The DNA of Candidatus R. tarasevichiae is also present in the ticks of D. nuttalli and H. concinna from the Altai Republic. The DNA of the classic pathogenic species, R. sibirica, was detected in ticks D. nuttalli and H. concinna in the Altai Republic, ticks D. silvarum, H. concinna and H. japonica douglasi in the Khabarovsk Krai. In addition, in the Khabarovsk Krai, the DNA of R. heilongjiangensis was detected in H. concinna ticks, and a DNA fragment common to R. sibirica subsp. mongolitimonae and R. conorii was detected in H. japonica douglasi ticks, which requires further study. Candidatus R. tarasevichiae is common in Ixodes mites (I. persulcatus, I. pavlovsky and their hybrids), in the Altai Republic in D. nuttalli and H. concinna. R mites. raoultii was detected in ticks of the genus Dermacentor D. nuttalli in the Altai Republic and D. silvarum in the Khabarovsk Krai. Conclusions. During molecular biological monitoring of rickettsias in endemic territories, the detection of R. raoultii masks the presence of the etiological agent of STT R. sibirica. This phenomenon makes it possible to explain the high incidence of STT in the studied territories, with the rare detectability of R. sibirica DNA during molecular biological screening in ixodic mites.
Assessing the susceptibility levels of chestnut cultivars/genotypes to Asian chestnut gall wasp (Dryocosmus kuriphilus Yasumatsu)
Authors: MÜFTÜOĞLU Başak , MERT Cevriye , GENÇER Nimet Sema
Published: March 2023

The Asian chestnut gall wasp Dryocosmus kuriphilus is a major insect pest affecting chestnut trees worldwide. Due to the galls that it creates on shoots and leaves, this pest prevents shoot development and blooming and decreases the fruit yield. In Türkiye, this pest was first seen in Gacık village of Yalova province in the year 2014. Today, it is seen in orchards and forests in different provinces of Marmara, Aegean, and Black Sea regions. The medium- and long-term control of this pest can be improved by making use of resistant or less-susceptible cultivars and hybrid clones. The susceptibility levels of our cultivars to this pest are not known. For this purpose, by using three infestation indicators, the susceptibility to Asian chestnut gall wasp (ACGW) of 3 hybrids (Castanea sativa x Castanea crenate) and 20 cultivars/genotypes (C. sativa), which came to the forefront via selection studies, were assessed for five years (2017-2021). The susceptibility to ACGW varied between the tested genotypes/cultivars and, since no gall development was observed in ‘YD-1’, ‘Tülü’, and ‘Ertan’ cultivars of C. sativa species, they were determined to be completely resistant to ACGW. Furthermore, the numbers of ACGW eggs on the buds of cultivars were recorded and it was found that ACGW laid eggs on the buds of all the cultivars. In microscopic analyses, it was revealed that the resistance originated from the prevention of larva development within the bud. The finding that resistant cultivars belong to C. sativa species is thought to be important for future genetic breeding programs.
The use of phytotherapy in hepatocellular carcinoma – a systematic review
Authors: URSU Cristina P. , MOIȘ Emil I. , FURCEA Luminița E. , POP Rodica S. , URSU Ștefan , SCHLANGER Diana , CIOCAN Andra , ZAHARIE Florin V. , PUIA Aida , AL HAJJAR Nadim , GRAUR Florin
Published: March 2023

Hepatocellular carcinoma (HCC) is one of the most common malignant tumours and the second most frequent cause of cancer-related death worldwide. The aim of this review is to identify whether phytotherapy has an effect over the treatment of HCC or if it is suitable as a combination with chemotherapy. A systematic review was performed in order to offer current information over the use of phytotherapy in HCC. We conducted an electronic search of articles published in English in peer reviewed journals between 2012-2022. After keywords were associated, 302 articles were found. After the exclusion of articles which did not meet the inclusion criteria, there were 77 articles eligible for abstract evaluation. The following were discarded: two case report, one systematic review, 36 in vitro studies and nine studies which discussed other pathologies or with no regard to phytotherapy. The remaining articles encompassed 27 in vivo studies of phytotherapy in hepatocellular carcinoma and two randomized control trials. This selection process is illustrated in the Prisma Flow Diagram. Amongst the evaluated articles, two of them researched the effect of phytotherapy over human subjects in two randomized control trials, while the others illustrated the outcomes of phytotherapy over hepatocellular carcinoma cells and murine specimens. To sum up, phytotherapy has proven its usefulness in hepatocellular carcinoma, especially throughout the following mechanisms: anti-inflammatory effect, suppressing malignant cell proliferation, inhibiting angiogenesis, stimulating apoptosis, and even sensitizing cells to chemotherapy.
Curso virtual en gestión de proyectos para la presentación de propuestas de reparación de los miembros de la fuerza pública ante la Jurisdicción Especial para la Paz
Authors: Cardozo Garcia Mayra Alejandra
Published: April 2023

Introducción: El presente artículo muestra los resultados de la manera como los AVA se constituyen en una herramienta esencial tanto para la estructura y diseño, como para la ejecución de cualquier tipo de curso virtual.

Metodología: El enfoque metodológico socio-constructivista y el aprendizaje por competencias permite el abordaje del propósito investigativo de corte mixto. La estructura curricular soportada en el curso se basa en la tríada Saber–Ser–Hacer, y se articula por medio de la taxonomía SOLO.

Resultados: El curso virtual en gestión de proyectos para la presentación de propuestas de reparación de los miembros de la fuerza pública ante la Jurisdicción Especial para la Paz, con sus seis módulos compartidos a través de Moodle, acoge la estrategia Social-Ad para llegar a la población objetivo. La prueba piloto se aplica a 11 participantes y ofrece resultados satisfactorios. La encuesta registra impresiones y recomendaciones; se atiende el informe alrededor de los estándares de evaluación y el informe sobre desarrollo del curso y desempeño de participantes.

Conclusiones: Abordar las temáticas curriculares en gestión de proyectos aprovechando los ambientes virtuales, resulta ser favorable, augurando la efectividad de su implementación entre sus usuarios.

Palabras clave: Ambiente Virtual de Aprendizaje, Curso virtual, Gestión de Proyectos, Jurisdicción Especial para la Paz, Miembros Fuerza Pública
Impacto del uso de TIC en los niveles de comprensión lectora en estudiantes del grado 5°JM del Colegio Nicolás Gómez Dávila
Authors: Romero Henao Edna Viviana , Melo Fontecha Sara
Published: April 2023

El proceso de investigación que se propuso en este documento aportó una descripción del impacto que tiene el uso de herramientas digitales que han logrado envolver al estudiante y a su vez, permitió establecer si además de elevar los niveles motivacionales pudo influir en el desarrollo de habilidades relacionadas con procesos de comprensión lectora. Por ello, el objetivo general plantea: “Describir el impacto del uso de las TIC en los niveles de comprensión lectora en estudiantes del grado 5°JM del Colegio Nicolás Gómez Dávila”. Para ello, fue necesario ahondar en las siguientes categorías de análisis: Comprensión Lectora, Herramientas TIC y Acompañamiento familiar en procesos de comprensión lectora. El enfoque de la investigación fue de carácter cualitativo y el diseño de la investigación estuvo bajo las premisas de la investigación – acción.

Para dar cuenta del objetivo de la investigación se aplicaron los siguientes instrumentos validados por un experto: una encuesta a los padres de familia, tres pruebas de entrada y tres pruebas de salida de comprensión lectora a 15 estudiantes del grado 5°JM.

Esto permitió generar algunas recomendaciones dirigidas al fortalecimiento de la compresión lectora mediada por las TIC.
The genus Hishimonus Ishihara in Australia (Hemiptera: Cicadellidae: Deltocephalinae: Opsiini) including description of three new species
Authors: Fletcher Murray , Dai Wu
Published: March 2023

The Australian species of Hishimonus Ishihara are reviewed. Three new species are added to the fauna: H. leichhardti sp. nov, H. malipatili sp. nov. and H. spatulatus sp. nov. Hishimonus diffractus Dai & Fletcher, is recorded from Australia for the first time and H. passiflorae (Evans) is redescribed. H. melaleucae (Kirkaldy) is excluded from the genus. A key for the determination of the Australian species of Hishimonus is provided. The relationships of the Australian fauna with the Oriental fauna are briefly discussed.
¿Por qué visitar lifestyle centers? Variables alternativas de atracción a través de un modelo de ecuaciones estructurales
Authors: Ortegón Cortázar Leonardo
Published: April 2023

sta investigación analiza los factores de atracción aplicados a los nuevos formatos de centros comerciales llamados lifestyle centers, que nacen para satisfacer las nuevas demandas de estilos de vida, con una mayor variedad de servicios y experiencias que mejoren la lealtad de visita, donde todavía existe un escaso número de investigaciones. Para tal efecto, se desarrolló un estudio de carácter explicativo a través de una encuesta aplicada a 398 visitantes. El análisis estadístico se realizó mediante una solución factorial y un modelo de ecuaciones estructurales para estimar los efectos de nueve variables latentes hacia la variable dependiente intención de visita. Los resultados revelan la existencia de los factores propuestos (accesibilidad y conveniencia, variedad de la oferta, ambiente físico, entretenimiento permanente, percepción de lujo, ambiente eco-natural, usos de tecnología, eventos especiales y calidad del servicio, complementando la literatura. Se discuten los efectos significativos de cada factor de atracción y su capacidad para influir en la intención de visita. Las conclusiones señalan una mayor relevancia frente a otras variables latentes tradicionales del ambiente físico, la calidad del servicio, la accesibilidad, realización de eventos, la presencia de servicios de tecnología, cuestiones que no habían sido documentadas en estudios previos, por lo que esta investigación contribuye al conocimientopara mejorar la capacidad de atracción de los lifestyle centers.
Covid-19 Salgınının Konut Tercihleri Üzerindeki Etkisi: İzmir İli Örneği
Authors: DİYADİN LENGER Aslı
Published: March 2023

Covid-19 salgını tüm dünyada, bir yılı aşkın bir süredir ekonomi, eğitim, sosyal yaşam ve çalışma hayatı gibi birçok alanda etkisini göstermektedir. Covid-19 salgınının etkisiyle bireylerin tüketim alışkanlıkları ve tercihlerinde belirgin değişiklikler yaşanmıştır. Temizlik ürünlerinin tüketimi artmış, maske zorunlu bir ihtiyaç haline gelmiş, hayat tarzında değişikliğe gidilmiştir. Bu bağlamda, çalışmanın temel amacı, Covid-19 salgınının tüketicilerin konut tercihleri üzerinde bir etkisi olup olmadığını anlamaktır. Çalışmada, dünyaca tanınan ve zincir olan bir konut danışmanlık firmasının İzmir ilinde faaliyet gösteren, bir ofisi (20 emlak danışmanı) ile görüşülmüş ve derinlemesine mülakat yöntemiyle veri toplanmıştır. Çalışmanın sonucunda, son bir yılda tüketicilerin konut tercihleri üzerinde keskin bir değişim olduğu ortaya çıkmıştır. Müstakil evlere doğru kayan talep ile birlikte, konut alımlarında nakit ödeme yöntemi tercihinin arttığı sonucu ortaya çıkmıştır. Artan talebin etkisiyle, fiyatlar yükselmiş ve yetersiz alan sebebiyle, yerleşim merkezden uzağa doğru kaymıştır.
Determinant Factors that Influence Customers' Experience in Fast Food Restaurants in Sungai Petani, Kedah
Authors: Jaini Azila , Ahmad Nor Asma , Mat Zaib Siti Zamanira
Published: March 2023

This study investigates the relationship between total restaurant quality and customers' experience in a local fast food restaurant. The objectives of this study are to determine the factors that lead to customers' positive experience and to recognize the elements that encourage people to dine-in at a chosen fast food restaurant. The study was conducted quantitatively, in which the convenience sampling method was chosen to collect the data. 373 questionnaires were collected and the findings were analyzed using the Predictive Analytics Software (PASW). Four critical factors of total restaurant quality were tested and the findings of this study proved that there is a positive relationship between three factors (food quality, service quality, and perceived value) and customers? experience. Perceived value is the main reason for people to dine-in at a chosen fast food restaurant. Overall, this study suggests that a fast food restaurant should focus on delivering services to the customers and simultaneously enhancing the other qualities in order to capture long-term relations with customers.
Overview of current software capabilities for EEG recording and analyzing
Authors: Ivanov A. A.
Published: April 2023

This article is aimed at familiarizing medical specialists involved in the registration and analysis of electroencephalographic (EEG) examinations with the basic principles of work and the capabilities of current computer software for EEG recording and analyzing. Understanding the basics of how the software works should help medical staff use all its functionality correctly and ultimately improve the quality of medical care. The basic and innovative capabilities of computer software in the field of mathematical processing and analysis of EEG signals are discussed, the limitations of using mathematical processing methods are described.
Determination of in Vitro Antioxidant, Antimicrobial Properties and COX-1/COX-2 Enzyme Inhibition Activity of Capparis Sicula
Authors: ACAR Nağihan , ÇELİKEZEN Fatih Çağlar , ŞAHİN İbrahim Halil , FIRAT Mehmet , KOÇYİĞİT Recep , KİREÇCİ Oğuz Ayhan
Published: April 2023

Since synthetic drugs cause many side effects and have a high cost, there has been increasing interest in the development of herbal-based drugs that have fewer side effects and are relatively inexpensive. Capparis sicula is traditionally used in the treatment of some diseases among people. For this purpose, the antioxidant and antimicrobial properties of the methanol extract of the Capparis sicula plant and its inhibitory effects on COX-1 and COX-2 enzymes were investigated. In the study, the antioxidant properties of the Capparis sicula plant were determined by DPPH and CUPRAC methods, while its antimicrobial properties were determined by the disk diffusion method. The effect of Capparis sicula on COX-1 and COX-2 enzymes was determined colorimetrically using commercial kits. The results showed that Capparis sicula had a significant antioxidant effect, but did not have any antimicrobial effect on standard strains of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Candida albicans. In addition, the inhibitory effect on the COX-1 enzyme was 4.23% for the first time, and the inhibition effect on the COX-2 enzyme was determined as 23.21%. As a result, the pharmaceutical, food and cosmetic industries can use Capparis sicula as an important source of natural raw materials.
Ansiedad y percepción subjetiva del esfuerzo en deportistas de Wushu - Sanda
Authors: Rondon H Jorge Mario
Published: March 2023

Es un estudio de enfoque cuantitativo, con diseño no experimental, descriptivo, transversal, con un muestreo por conveniencia; con el objetivo de analizar aspectos de carga psicológica pre competencia de la Selección Colombia de Wushu modalidad Sanda. Participaron un total de 23 deportistas élite, adscritos y debidamente afiliados a la FCW (73.9% hombres y 26% mujeres) con rango de edad 20-35 años (M=25 DT=4.59). Se les aplicó, la prueba de P.S.E. y ansiedad, considerando que el impacto de las cargas no depende sólo de su coste energético, sino que incluye la influencia de otros estresores morfológicos, sociales y psicológicos. A nivel de P.S.E. se observó que los hombres percibieron el esfuerzo como Moderado (3) y un poco severo (4) en tanto que las mujeres percibieron el esfuerzo cómo severo (5,6) incidiendo de pronto en los niveles de ansiedad. Por otra parte, los resultados arrojados en nivel de ansiedad estado y depresión muestran con mayor incidencia a las mujeres siendo este un estado emocional o condición transitoria, a diferencia de los hombres que presentan mayores niveles de ansiedad rasgo disposición conductual. Para el análisis y procesamiento de la información se utilizó el paquete estadístico STATA, versión 15.0 para Windows.
Individual Adaptation in the Face of Enterprise IT Changes in the Organization
Authors: Hanafizadeh Payam , Taherianfar Ahmad , Alami Neisi Masood
Published: March 2023

Individual adaptation plays an important role in using enterprise information technology (IT). In the life cycle of enterprise IT in the organization, various factors can change IT and its related work tasks. Therefore, users have to adapt to these changes. Since the use of information technology depends on the capabilities acquired through individual adaptation behaviours, it is essential to examine these behaviours in more detail. This study presents the factors affecting individual adaptation behaviours as a model. The results of the experimental test of the model show that technology experience and IT knowledge affect an individual’s perception of task difficulty, and personality traits moderate the relationship between task difficulty and individual adaptation behaviours. One of the advantages of the proposed model is separating the roles of managers and users in different periods of enterprise IT adaptation. Also, paying attention to users’ personal characteristics in explaining the differences in adaptation behaviours among employees is another advantage of this model.
Editorial: From History to Infrastructure
Authors: Campbell Leith H.
Published: March 2023

This editorial comes in three parts: encouragement to delve into the start of long-distance telecommunications in Australia; some remarks on telecommunications as infrastructure; and a brief introduction to the papers in this issue.
Development and validation of stability indicating RP-HPLC method for determination of aspirin and pantoprazole sodium in synthetic mixture stability indicating HPLC method
Authors: Yadav Preeti , Patel Pinak , Shukla Rashmi , Detholia Krunal , Singh Anamika
Published: April 2023

The present study describes a new accurate and precise stability indicating reverse phase HPLC method for quantitative computation of pantoprazole sodium and Aspirin from physical simulated mixture. The proposed chromatographic method employs Hypersil ODS C18 column (250 x 4.6 mm, 5μ) as the stationary phase and combination of methyl alcohol and water in ratio of 70: 30 v/v as the elution medium. Overall separation was carried out at 0.8 ml/minute flow rate and elution was monitored at 254 nm. The proposed system gave well resolved peak of Aspirin and Pantoprazole sodium with elution time of 2.32 and 5.85 minute respectively. Same system was effective in separation of active components and degradation products when the components were subjected to forced degradation as per regulatory guidelines (ICHQ1). Finally, the optimized method was successfully validated as per ICH Q2R1 guidelines and applied for quantitative analysis of both active components in synthetic mixture.
Micromorphological soil assessment in abandoned quarry dumps of the Central Caucasus, Russia
Authors: TEMBOTOV Rustam , ABAKUMOV Evgeny , Jİ Xiaowen
Published: April 2023

This study compared the micromorphological and agrochemical metrics in soils from the quarry dumps and zonal soils, the Central Caucasus. Soil micromorphological investigations are important tool for evaluation of soil dynamics after anthropogenic impacts on terrestrial ecosystems. The results showed that the carbon content in the primary soil of the sand and gravel quarries was lower than that in the reference soil. The differences detected were statistically significant for both the Urvan plot soils (t = 11.95; p = 0.000) and the Progress plot soils (t = 18.73; p = 0.000). In contrast, in the quarry with clay bottom substrate (Gerpegezh), no significant difference was found between the reference and postmine soils. The reference soil around the sand and gravel quarries was slightly more acidic than the primary soil. In the clay quarry, the primary soil was more acidic with a strong acidic value, while the reference soil was neutral. The difference of nutrients (P, K, NH4+, NO3-) between the primary and reference soils were negligible. The only exception was the NO3- content in the reference soil of Progress settlement, where it was significantly higher (t = 4.19; p = 0.002) than in the original soil of the site. No difference was observed for the mineral component of the primary soil. Investigation of key zonal soils of the region. Zonal Caucasus soils: Phaeozem Gleiyc, Phaeozem and Umbric Retisol are different in terms of micro texture. Thus, Phaeozem Gleiyc characterizes by microstructure composed by primary angular mineral forms. Phaeozem and Retisol demonstrated formation of biogenic structure with alteration of mineral particles. Data obtained show that rapid self revegetation of the quarries results in initialization of primary soil formation and transformation of the soil microstructure and organization on the micro level.
Assessment of land use land cover dynamics and its impact on springs water in Ritung Khola Sub-Watershed, Myagdi district, Nepal
Authors: TİMİLSİNA Sachin , SHRESTHA Saurav , TRİPATHİ Shankar , BHATTARAİ Rajeev , MİSHRA Shambhu Kumar , REGMİ Raju Raj , PAUDEL Diwakar , MİYA Mahamad Sayab
Published: April 2023

Land Use Land Cover (LULC) Change has emerged as a significant environmental issue and a worry for the sustainable use of natural resources. This study was performed to determine the rate in change of land cover and its significant impact on springs water in the Ritung Khola sub-watershed of Myagdi district, Nepal, between 2010 and 2020. This study analyzes LULC dynamics and it’s impact on springs water using satellite imageries (Landsat 5 TM and Landsat 8 OLI/TIRS) and focus group discussions with the inhabitants. We used Supervised Maximum Likelihood Classification algorithm to classify attributes of the LULC changes. The results demonstrated a significant change in LULC during those ten years (2010-2020). The area covered by agricultural land and human settlements significantly increased by 313.54% and 367.14%, respectively. On the contrary, barren land, water bodies and forest cover have been reduced by 37.52%, 13.16% and 5.26%, respectively. The number of active springs followed decreasing trend as many of them were completely displaced or dried due to erosions and frequent landslides. The findings from this study are expected to facilitate the planning process adopted to prevent springs under the threat of extension and mitigate the water scarcity problem.
Molecular mechanisms of wound healing: the role of zinc as an essential microelement
Authors: Lebedeva Svetlana A. , Galenko-Yaroshevsky (Jr.) Pavel A. , Samsonov Mikhail Yu. , Erlich Arkadiy B. , Zelenskaya Anait V. , Margaryan Arus G. , Materenchuk Maria Yu. , Arshinov Iaroslav R. , Zharov Yuriy V. , Shelemekh Olga V. , Lomsadze Izabella G. , Demura Tatiana A.
Published: April 2023

Introduction: In the course of evolution, humans developed a number of complex multi-step wound healing mechanisms which limit the infectious agents access to the bloodstream, protect the organism from blood loss, and restore skin integrity. The process of skin wound healing includes the following stages: haemostasis, inflammation, proliferation, and remodeling. These processes are possible because of modulators, growth factors, cytokines, matrix metalloproteinases and cellular receptors, as well as some trace elements like zinc.
Materials and Methods: The presented data was analyzed and compiled using all relevant articles describing the role of zinc in blood coagulation, proliferation, damaged tissues regeneration and angiogenesis.
Results and Discussion: There are some on-going studies about zinc effects on blood coagulation, proliferation, damaged tissues regeneration and angiogenesis. However, molecular mechanisms of these processes are not yet fully understood and require further study.  The analysis of scientific efforts to investigate the role of zinc in wound healing molecular mechanisms is especially relevant to the understanding of treatment of skin wound injuries.
Conclusion: Wound healing is a complex multi-phase process consisting of several phases. Each stage involves metal ions, primarily zinc, which stimulates re-epithelialization, decreases inflammation and bacterial growth. The use of known zinc-based drugs is accompanied by side effects and low efficacy due to low skin absorption. These factors significantly limit use of such drugs and highlight the urgency of finding new, more effective and safe treatment. The emerging field of nanobiotechnology may provide an alternative platform to develop new therapeutic agents for the wound healing process.
Graphical Abstract
A case developing bilateral bullae due to COVID-19 infection and operated for recurrent pneumothorax
Authors: ERSÖZ KÖSE Elçin , BOYACIOĞLU Kaan Ayberk , ALPARSLAN BEKİR Sümeyye , ATİNKAYA BAYTEMİR Cansel , YALÇINKAYA İrfan
Published: April 2023

In December 2019, a novel coronavirus (COVID-19) pneumonia emerged in Wuhan, China and has rapidly spread to multiple countries worldwide. Pulmonary parenchymal opacities are often observed during chest radiography. Pneumothorax was reported in 1% of patients in studies. In this paper, we aimed to present a patient with a history of long-term hospitalization in intensive care unit due to COVID-19 pneumonia who was operated for right recurrent pneumothorax secondary to COVID-19 after discharge.
Public policies for wellbeing with justice : a theoretical discussion based on capabilities and opportunities
Authors: Krishnakumar Jaya
Published: March 2023

En este artículo defendemos la idea de que la combinación de estas teorías arroja nueva y útil luz para entender el bienestar y su relación con las políticas públicas, por la forma en que complementan el razonamiento positivo y el normativo, dando respuesta a nuestras dos preguntas. A lo largo de este documento, argumentamos que ni CA ni EOp, por sí solos, presentan una combinación de bienestar y justicia que pueda proporcionar lineamientos formales de política para mejorar el bienestar con justicia a través de un principio de optimización adecuado. Presentamos argumentos en busca de respuestas claras a nuestras dos preguntas y mostramos que una integración ordenada de elementos de ambos enfoques conduce a una solución plausible. El artículo está estructurado de la siguiente manera: en la sección 2 presentamos algunos enunciados básicos de las teorías de Sen y Roemer, recordando brevemente sus elementos esenciales. En las secciones 3 y 4 analizamos respuestas plausibles a las dos preguntas planteadas en estos párrafos introductorios, respectivamente, en torno al enfoque CA y EOp. En la sección 5 proponemos una combinación teórica así como una derivación técnica de nuestra política óptima e ilustramos su utilidad. Finalmente la sección 6 concluye
Antidepressants and Suicide: 7,829 Inquests in England and Wales, 2003–2020
Authors: Read John
Published: March 2023

Background:Antidepressant (AD) medications increase suicidality for some, or all, age groups. Some, or all, types of ADs, are frequently used in suicides involving overdoses.

Methods:The article examines a previously unanalyzed data set summarizing 7,829 media reports of Coroners’ inquests in England and Wales that mention ADs, between 2003 and 2020.

Results:The most frequently cited ADs were SSRIs (48.9%) and tricyclics (24.6%). The specific drugs cited most often were the SSRI drug citalopram (19.8%) and the tricyclic drug amitriptyline (17.5%). Of 2,329 cases of death by overdose, 933 (40.1%) were overdoses of ADs, 512 of which (54.9%) did not involve other substances. The ADs most frequently named were amitriptyline (186), and citalopram (86). A further 929 were overdoses of unnamed medicines, a proportion of which may have been ADs.

Limitations:The data set, which relies primarily on archives of local newspapers, is incomplete and therefore underestimates the total numbers involved. The accuracy of coroners’ verdicts is not perfect.

Conclusions:If preventing suicide is a primary reason for prescribing ADs, this data set includes several thousand people for whom the drugs clearly did not work. Furthermore, about 1,000 people used the drugs that were supposed to alleviate their depression to kill themselves. Systematic analyses of all inquests would be more informative. Meanwhile, reducing the overprescribing of these relatively ineffective and, for some, lethally dangerous substances is suggested, to reduce suicides.