bluuebunny/crossref_metadata_2025 huggingface dataset:
The potential of pharmacotranscriptomic markers for predicting mycophenolic acid efficacy in children with steroid-dependent nephrotic syndrome
Authors: Pakhomova V. P. , Morozov S. L. , Voinova V. Yu. , Shimanova A. B.
Published: November 2024

Nephrotic syndrome is one of the most common glomerular diseases in childhood. It is known that about half of patients with nephrotic syndrome develop dependence on steroid therapy, which requires the inclusion of a treatment regimen of selective immunosuppressive therapy. Mycophenolic acid (MPA) has been identified as a promising drug for steroid-resistant nephrotic syndrome, and it forms the basis of immunosuppressive therapy for this condition. The present study evaluates the importance of determining the expression of genes responsible for the metabolism of mycophenolic acid in patients with steroid-dependent nephrotic syndrome to maintain stable clinical and laboratory remission of the disease. The article demonstrates the significance and role of MDR1, UGT1A7, UGT1A9 and UGT2B7 gene expression as potential markers of increased risk of relapses and opens up prospects for the use of a transcriptomic approach to identify patients who require careful selection of pharmacotherapy. Although the results obtained are promising, changes in the expression of metabolic enzymes are only one of several factors that contribute to the effectiveness of treatment. Based on these data, it may be possible in the future to develop personalized monitoring strategies that can help tailor treatment to individual patients and increase its effectiveness.
Phenotypic and genotypic features of children with familial hypercholesterolemia
Authors: Sadykova D. I. , Slastnikova E. S. , Galimova L. F. , Shagimardanova E. I. , Nigmatullina R. R. , Salakhova K. R. , Khaliullina Ch. D.
Published: November 2024

Dyslipidemia is a metabolic disorder in which the ratio of lipid particles in the blood changes. It is often associated with other conditions and diseases during childhood. Lipid metabolism disorders in children can be divided into two categories: primary, which are inherited from parents or occur de novo, and secondary, which occur during life. Familial hypercholesterolemia is the most common type of primary disorder, characterized by an increase in blood lipoprotein levels. However, the lipid composition in children with established familial hypercholesterolemia can vary. One factor that may contribute to higher lipid levels in these children is the presence of mutations in the apolipoprotein E gene.

Purpose of the study was to investigate the phenotypic and genotypic features of children with familial hypercholesterolemia in order to better understand this condition.

Materials and methods. Children with a clinical diagnosis of familial hypercholesterolemia underwent DNA sequencing to identify mutations in genes related to LDLR, APOB, LDLRAP1, and APOE genes.

Results. Children with familial hypercholesterolemia most often carry the polymorphism c.388T>C in the ApoE gene (g.45411941T>C, p.Cys130Arg, rs429358). Also, 24.1% of children were found to be isolated carriers of various ApoE haplotypes, which are risk factors for dyslipidemia. In children with a pathogenic mutation characteristic of familial hypercholesterolemia and carriage of polymorphisms in the ApoE gene, the LDL level was statistically higher compared to non-carriers.

Conclusion. Carriage of various polymorphisms in the ApoE gene in children with familial hypercholesterolemia may lead to an increase in the already elevated levels of LDL and total cholesterol.
Pathomorphosis of acute otitis media in children: when does a pediatric infection become surgical?
Authors: Abramenkova A. S. , Luchkina E. V. , Andreeva I. G. , Mamleev R. N.
Published: November 2024

The incidence of complications from acute otitis media in children, such as mastoiditis, tends to increase. We analyzed 57 case histories of children who had undergone an anthromastoidotomy. The main reasons for treatment failures in acute otitis media include underestimating the vaccination status of the child, lack of antibiotic therapy, prescribing antibiotics in low doses or for a short period of time, using drugs that are not active against pneumococcal infections, and prescribing only topical therapy. Considering these factors can reduce the need for surgery in pediatric patients with this infection.
Percepção Ambiental e Etnobotânica na Comunidade Paraíso Grande, Humaitá-AM, Brasil
Authors: Cavalcante Felipe Sant'Anna , Chaves Rosineide Campos , Souza Doraci Brito de , Furtado Fabiana Caetano , Scudeller Veridiana Vizoni
Published: November 2024

Este estudo teve como objetivo realizar uma análise das condições socioeconômicas, etnobotânicas e da percepção ambiental na comunidade Paraíso Grande em Humaitá-AM. Utilizou-se uma abordagem mista, incluindo entrevistas e questionários semiestruturados aplicados para 20 famílias. Os resultados revelaram que a comunidade é predominantemente composta por pessoas com idades entre 20 e 40 anos. A maioria (30%) dos entrevistados é casada e apresenta em média dois filhos. Em geral as famílias ganham menos que um salário-mínimo para sua sobrevivência, por meio do trabalho na roça/agricultura. Observou-se uma ampla gama quanto ao nível de escolaridade dos entrevistados, prevalecendo o ensino fundamental incompleto. Foram mencionadas 31 espécies medicinais, sendo as mais citadas o mastruz, hortelã, limão e acerola. As doenças mais citadas entre as tratadas com plantas medicinais foram gripe, infecções em geral, dores no estômago e problemas cardíacos. Todos os entrevistados afirmaram que utilizam as plantas medicinais no preparo de medicamentos para alívio ou cura de doenças e cultivaram algumas dessas em seus quintais. A grande maioria dos entrevistados foi composta por mulheres e adquiriram esse conhecimento oriundo de seus familiares. As folhas foram a parte da planta mais usada e preparada em forma de chá. Além disso, a comunidade utiliza as plantas medicinais pois no local que residem não existe atendimento médico de saúde, o que estimula o uso desses vegetais na cura e/ou alívio de doenças. Dentre os problemas ambientais que a comunidade enfrenta ou já enfrentou, destacou-se as enchentes, seguido de queimadas e desmatamentos, os quais acabam prejudicando o crescimento e desenvolvimento das plantas. Dessa forma, é recomendado evitar esses problemas ambientais para a conservação dessas espécies vegetais tão importantes na comunidade.
Matas Ripárias do Cerrado sob Intensa Fragmentação Apresentam Alta Diversidade, porém baixa Similaridade de Espécies
Authors: Reis Jessica Silva dos Silva dos , Junqueira Daniela Inácio , Lemke-de-Castro Mara , Deus Marcos Henrique André de , Barroso Renata de Freitas , Pedroso Everton Tizo
Published: November 2024

A vegetação natural da Bacia Hidrográfica do Rio Meia Ponte encontra-se marcantemente fragmentada em consequência da conversão de hábitat nas últimas décadas. Desse modo, realizou-se um estudo descritivo dos padrões fitossociológico, taxonômico e de diversidade florística em comunidades ripárias do Cerrado na Microrregião Meia Ponte de Goiás. Foram monitorados 32 transectos de 20m x 4m, subdivididos em quatro cursos d’água afluentes em três microbacias hidrográficas. Para a identificação taxonômica, foram consideradas a composição vegetativa, as características morfológicas e o comparativo da diversidade florística entre as áreas de estudo. Desse modo, foram encontrados 6.285 indivíduos vivos de angiospermas, representando uma riqueza de 152 espécies divididas em 57 famílias. As famílias mais representativas (totalizando 51% da abundância) foram: Acanthaceae, Annonaceae, Fabaceae, Malvaceae, Meliaceae, Poaceae e Rubiaceae. Observa-se pelas análises fitossociológicas uma composição de espécies vegetais característica e típica de formações ripárias do Cerrado sul goiano. Para tal, registrou-se áreas com composição florística heterogênea, elevada abundância, riqueza e variabilidade de espécies com baixa uniformidade entre as áreas de estudo. Ainda, os resultados sugerem uma maior distribuição vegetativa nas matas ripárias sob a presença de estresse ambiental. Esses resultados confirmam a importância de medidas de conservação das Áreas de Preservação Permanentes (APPs) do Cerrado e da Bacia Hidrográfica do Rio Meia Ponte. No entanto, recomendam-se estudos das formas de uso da terra e cobertura de solo, passados, atuais e futuros (sensoriamento remoto), para compreensão do efeito histórico das ações humanas sob a vegetação das áreas estudadas.
Broń oblężnicza epoki średniowiecza i jej zastosowanie (XI –XII w.) w świetle najnowszych badań
Authors: Juchimiuk Hubert
Published: November 2024

Sztuka i technika oblężnicza były jednymi z ważniejszych aspektów średniowiecznych teatrów wojennych. Już od starożytności opracowywano narzędzia służące zdobywaniu miast i niszczeniu umocnień przeciwnika. Niestety, ze względu na niewielką ilość źródeł, zarówno tych pisanych, jak i niepisanych, stan wiedzy jest niewystarczający i dotyczy to tak badań źródłoznawczych, jak i tych z zakresu archeologii eksperymentalnej. Rolą tego artykułu jest usystematyzowanie dostępnej wiedzy na temat przyrządów oblężniczych epoki średniowiecza, a następnie przybliżenie jej użyteczności w wojsku piastowskim w oparciu o dostępną literaturę i źródła, którymi dla epoki wczesnopiastowskiej są: Kronika Polska Anonima zwanego Gallem oraz Kronika Thietmara.
THE EFFECT OF MARINATION WITH RED GINGER (Zingiber officinale Rosc.) ON CHEMICAL AND HEDONIC QUALITY OF DRIED BEEF
Authors:   Universitas Diponegoro, Dwiloka Bambang , Prasasti Rahel Nathania ,   Universitas Diponegoro, Nurwantoro Nurwantoro ,   Universitas Diponegoro
Published: November 2024

Red ginger (Zingiber officinale Rosc.) is a commonly utilized spice plant in blends and marinades. The research was conducted to determine the effect of different red ginger blend concentrations on fat levels, protein levels, antioxidant activity, and hedonic quality of dried beef. The research used a Randomized Block Design and descriptive analysis. Treatments were differentiated by adding different concentrations of red ginger blend (P0 = 0%, P1 = 5%, P2 = 10%, P3 = 15%, and P4 = 20%). The addition of a 15% red ginger blend is the best treatment for the chemical properties of dried beef, while the addition of a 5% red ginger blend is the best treatment for the hedonic properties of dried beef.
Op straat geïntimideerd, in het parlement genegeerd. Vrouwen en de 'inclusieve' democratie tijdens de Bataafse republiek
Authors: Hagen Edwina
Published: November 2024

Vrouwen verschaften zich tijdens de Bataafse republiek toegang tot het parlementair gezag door collectief te petitioneren. Hoewel de oprichters van het (eerste) parlement een democratische inclusieve[re] regering pretendeerden, drukten de volksvertegenwoordigers de stem van petitionerende burgeressen (‘vrouwtjes’) weg uit het publieke discours. Deze strategie kan worden geduid als ‘silencing’, een van de vele beproefde vormen van karaktermoord.
Re-wilding the Night: Understanding How Darkness Is Valued Through the Nighttime Light Ecology of Bonn Botanical Gardens
Authors: Griffiths Rupert , Powell Alison , Stone Taylor , Dunn Nick , Dijkstra Iris , Hector Luca , Müller Andreas Christian
Published: November 2024

Rewilding the Night is an interdisciplinary research project that aims to reimagine the urban night by capturing and communicating the qualities and rhythms of both artificial and natural light at night. Through a collaborative and experimental approach, the project seeks to make the urban night legible by employing sensor technologies and data visualization techniques, thus fostering a deeper engagement with and appreciation for urban darkness. The project has three aims—first, to capture and analyse environmental light data in Bonn Botanical Gardens, Germany to create an accessible understanding of the variations in natural and artificial nighttime light. Second, to use this groundwork to inform subsequent workshops to capture public perceptions and values regarding darkness; and third, to develop lighting prototypes that respond to light data and the insights gained through the workshops. Central to the project is the re-evaluation of urban darkness by questioning and expanding the normative frameworks surrounding urban lighting. The project underscores the importance of interdisciplinary research and design in addressing complex urban challenges, offering a model for future research aimed at creating more livable, sustainable, and inclusive urban night environments for both humans and non-humans.
Echoes of Dissent: The Transformative Power of Sound in Iran's Urban Nightscapes
Authors: Dadpour Rana
Published: November 2024

The suppression of public dissent in Iran has catalysed alternative forms of resistance, most notably Nocturnal Rooftop Slogan Chanting (NRSC). This study explores NRSC as an urban phenomenon, illuminating its role in reshaping nightscapes under an authoritarian regime. How can politically disenfranchised citizens reclaim urban spaces and assert their voices under oppressive conditions? It is argued that NRSC creates alternative sonic geographies, challenging conventional narratives of nightscapes and expanding spaces of dissent. Combining theoretical analysis with empirical observations, this study includes a thematic analysis of 158 videos of NRSC from 2021 to 2023 and provides insights into the characteristics and content of these protests. The findings reveal that NRSC fosters communal identities and challenges state control through the creation of dispersed, anonymous, yet interconnected acts of sonic occupation. It thus transforms urban nights into platforms for collective expression and symbolic resistance. The study also demonstrates that NRSC's effectiveness lies in its ability to leverage the urban nightscape, particularly the vertical dimension of rooftops, to create a pervasive soundscape of dissent. It invites further research into the role of sensory experiences in shaping political landscapes and suggests a re-evaluation of urban nights as crucial spaces of identity formation and resistance.
Stability Improvement of Multimachine System Using Back-To-Back Converters
Authors: Wang Minyang , Zhang Daming , Yuan Liang
Published: November 2024

As the penetration level of inverter-based generators continues to increase, it becomes crucial to reduce power oscillations between inverters and synchronous generators (SG) to improve system stability. This paper uses a multimachine system as the research platform and proposes a grid separation method employing a multi-terminal back-to-back converter. The converter is designed to be placed at the point of common coupling (PCC) in the original multimachine system and can divide the original grid into multiple microgrid regions while retaining the ability to transmit power between different regions. Each microgrid or region contains a self-regulated power source such as grid-forming (GFM) inverter or synchronous generator, which controls key power characteristics such as frequency and voltage within its region. The back-to-back converter facilitates power transmission between different regions. The AC-DC-AC conversion process ensures isolation and simplification of control over each microgrid’s power characteristics. The performance of inverters with different control strategies in each microgrid has been investigated, and the characteristics of various inverters are compared and demonstrated. Additionally, it was found that the battery storage requirements in each inverter-based microgrid are reduced using this method. The results are verified through MATLAB/SIMULINK simulations.
Digital Health Innovations to Catalyze the Transition to Value-Based Health Care
Authors: Zhang Lan , Bullen Christopher , Chen Jinsong
Published: November 2024

The health care industry is currently going through a transformation due to the integration of technologies and the shift toward value-based health care (VBHC). This article explores how digital health solutions play a role in advancing VBHC, highlighting both the challenges and opportunities associated with adopting these technologies. Digital health, which includes mobile health, wearable devices, telehealth, and personalized medicine, shows promise in improving diagnostic accuracy, treatment options, and overall health outcomes. The article delves into the concept of transformation in health care by emphasizing its potential to reform care delivery through data communication, patient engagement, and operational efficiency. Moreover, it examines the principles of VBHC, with a focus on patient outcomes, and emphasizes how digital platforms play a role in treatment among tertiary hospitals by using patient-reported outcome measures. The article discusses challenges that come with implementing VBHC, such as stakeholder engagement and standardization of patient-reported outcome measures. It also highlights the role played by health innovators in facilitating the transition toward VBHC models. Through real-life case examples, this article illustrates how digital platforms have had an impact on efficiencies, patient outcomes, and empowerment. In conclusion, it envisions directions for solutions in VBHC by emphasizing the need for interoperability, standardization, and collaborative efforts among stakeholders to fully realize the potential of digital transformation in health care. This research highlights the impact of digital health in creating a health care system that focuses on providing high-quality, efficient, and patient-centered care.
The Impact of the COVID-19 Pandemic on Oldest-Old Social Capital and Health and the Role of Digital Inequalities: Longitudinal Cohort Study
Authors: Valla Luca Guido , Rossi Michele , Gaia Alessandra , Guaita Antonio , Rolandi Elena
Published: November 2024

Background

During the COVID-19 pandemic, information and communication technology (ICT) became crucial for staying connected with loved ones and accessing health services. In this scenario, disparities in ICT use may have exacerbated other forms of inequality, especially among older adults who were less familiar with technology and more vulnerable to severe COVID-19 health consequences.

Objective

This study investigated changes in ICT use, psychological and physical health, and social capital before and after the pandemic among the oldest old population (aged 80 years or older after the pandemic) and explored how internet use influenced these changes.

Methods

We leveraged data from the InveCe.Ab study, a population-based longitudinal cohort of people born between 1935 and 1939 and living in Abbiategrasso, a municipality on the outskirts of Milan, Italy. Participants underwent multidimensional assessment at baseline (2010) and after 2, 4, 8, and 12 years. We restricted our analysis to cohort members who participated in the last wave (ie, 2022) and who did not have a diagnosis of dementia (n=391). We used linear mixed models to assess the impact of COVID-19 and time on changes in social capital, physical and psychological health, and ICT use in a discontinuity regression design while controlling for age, sex, education, and income satisfaction. Then, we assessed the influence of internet use and its interaction with COVID-19 on these changes.

Results

COVID-19 had a significant impact on social relationships (β=–4.35, 95% CI 6.38 to –2.32; P<.001), cultural activities (β=–.55, 95% CI –0.75 to –0.35; P<.001), cognitive functioning (β=–1.00, 95% CI –1.28 to –0.72; P<.001), depressive symptoms (β=.42, 95% CI 0.10-0.74; P=.009), physical health (β=.07, 95% CI 0.04-0.10; P<.001), and ICT use (β=–.11, 95% CI –0.18 to –0.03; P=.008). Internet use predicts reduced depressive symptoms (β=–.56, 95% CI –1.07 to –0.06; P=.03) over time. The interaction between internet use and COVID-19 was significant for cultural activities (β=–.73, 95% CI –1.22 to –0.24; P=.003) and cognitive functioning (β=1.36, 95% CI 0.67-2.05; P<.001).

Conclusions

The pandemic had adverse effects on older adults’ health and social capital. Contrary to expectations, even ICT use dropped significantly after the pandemic. Internet users maintained higher psychological health regardless of time and COVID-19 status. However, COVID-19 was associated with a steeper decline in cognitive functioning among internet nonusers. Policy makers may develop initiatives to encourage ICT adoption among older adults or strengthen their digital skills.

Trial Registration

ClinicalTrials.gov NCT01345110; https://clinicaltrials.gov/study/NCT01345110
Study on The Impact of Gelatin Coating Containing Lactobacillus acidophilus and Lactobacillus reuteri on Chicken Fillets Shelf Life
Authors: Kamal Rohullah , Ahmadzai Noorullah , Samimi Sayed Rahman
Published: November 2024

The purpose of this study is to assess how chicken fillet shelf life and sensory evaluation are affected by 1% Gelatin coating containing Lactobacillus acidophilus PTCC 1643 and Lactobacillus reuteri ATCC 1655. Probiotic-containing cultures were introduced straight to the coating solution in this investigation. Measures were taken of the chemical (pH, TVB-N, peroxide value), microbiological (Total viable count (TVC), psychrotrophic count (PTC), Enterobacteriaceae, and Pseudomonas spp.), and sensory properties. During the storage of the chicken fillet, which was kept at 4° C for intervals of 0, 3, 6, 9, and 12 days, the antimicrobial properties of the coating in the groups treated with gelatin, Lactobacillus acidophilus, and Lactobacillus reuteri were significantly (p<0.05) higher than those in the control groups, despite the fact that the results showed the highest chemical properties and sensory score across all parameters. However, gelatin + Lactobacillus reuteri and gelatin + Lactobacillus acidophilus did not differ significantly (p<0.05). Additionally, samples treated with gelatin and probiotics showed no changes in color or texture, but their odor and taste scores decreased. We draw the conclusion that gelatin is an appropriate matrix for probiotic incorporation and long-term fillet storage.
Lemongrass-Synthesized Silver Nanoparticles as Preservatives of Fermented Locust Beans
Authors: Saliu Bolanle Kudirat , Agbabiaka Tariq Oluwakunmi , Akolade Jubril Olayinka
Published: November 2024

Fermented locust beans (FLB), produced from Parkia biglobosa (Mimosaceae-Fabaceae), are used in many parts of West Africa, including Nigeria, as condiments to enhance the taste and nutritional quality of foods. These benefits are, however, marred by the short shelf-life of FLB. Traditional preservative methods and the use of chemicals have their shortcomings. This study, therefore, investigated the effectiveness of lemongrass-synthesized silver nanoparticles (LSSNP) as a preservative of FLB. The LSSNP was prepared, characterized, and used to treat fresh FLB at 10% v/w. Dynamic light scattering analysis revealed a mean hydrodynamic size of 89 nm for the LSSNP, while transmission electron micrograph showed roughly spherical particles with an average size of 100 nm. Bacillus licheniformis KGEB16, B. licheniformis APBSWPTB167, B. licheniformis PS4, B. subtilis CICC10148, and Enterobacter xiangfangensis M5S2B6 isolated were susceptible to LSSNP with comparable zones of inhibition to reference antibiotics. A significant reduction of the microbial load of FLB by up to 63.7% due to LSSNP treatment was achieved. The organoleptic and proximate properties of LSSNP-treated FLB were preserved. A histo-morphological study showed normal hepatic architecture in rats fed with LSSNP-treated FLB. This study showed that LSSNP possesses antimicrobial properties and can be employed as a green and safe alternative for the preservationof FLB.
Fiber-Reinforced composite resin bridges as a treatment alternative for posterior missing tooth
Authors: Waskitho Arief , Putri Anggun Kharisma
Published: November 2024

Dental restoration alternatives for posterior missing tooth range from dental bridges to implant dentures. Fiber-reinforced composite (FRC) resin bridge is one option for the replacement of a single tooth missing. FRC bridge is known as an alternative replacement method for single posterior missing tooth with minimally invasive preparation of abutment teeth. The simplicity of the production method in the FRC bridge provides the possibility of a single-visit bridge treatment. This report aims to present two successful treatments for missing posterior tooth by two different methods of immediate restoration using the FRC resin bridge. Treatments were performed directly using two different fiber materials, pre-impregnated quartz unidirectional fiber, and quartz fiber post. The use of unidirectional quartz fiber and quartz fiber post in the posterior tooth exhibited superior results due to its strength and geometry of fiber placement. In conclusion, the fiber-reinforced composite bridge is a possible option for managing the upper posterior missing tooth.
Research on the Visual Image Shaping of Tourism Brand in Panyu District, Guangzhou
Authors: Pei Wen
Published: November 2024

The prominent visual image of regional tourism brands often gives people a strong attraction and profound influence, increases the recognition of regional tourism, and stimulates consumers' consumption desire. For tourism practitioners, the creative application of tourism brands and visual images is conducive to product innovation and promotion. The first part of this paper introduces the research background, purpose and significance of the subject; The second part defines the concept and discusses the basic theory. The third part takes Panyu District as an example, analyzes the development and change of tourism brand image, probes into the factors that affect tourism brand, and studies the visual image building of tourism brand law on this basis. The aim is to provide some reference ideas for regional tourism brand visual image building and brand quality improvement.
A Corpus-Based Analysis of Pauses in Chinese-English Consecutive Interpreting of Chinese English Majors
Authors: Qin Wenxinxin
Published: November 2024

This study aims to investigate pause characteristics and probe into the main reason for unnatural pauses in Chinese-English consecutive interpreting. The data were from the Parallel Corpus of Chinese EFL Learners-Spoken (PACCEL-S), which includes phonetic materials in the interpretation part of TEM-8. Forty interpreters were divided into four groups according to their scores and gender. Their recordings and transcribed texts were annotated and analyzed to provide a comprehensive overview of pausing. The findings are: (1) Pauses often occur in C-E CI. Interpreters use more UPs and unnatural pauses. (2) There is no interaction between proficiency and gender in pause duration and frequency, as well as the two indicators of unnatural pauses. (3) UP duration is affected by proficiency, and females tend to produce more FPs and unnatural pauses. (4) FP and UP invariably occur together but do not show linear correlation. (5) Interpreters tend to pause before content words, and unnatural pauses are mainly induced by notional word retrieval difficulty. By discussing pauses and explaining the leading motivation for unnatural pauses from the perspective of lexical retrieval, this study informs readers of the nature and features of pauses and provides suggestions for stakeholders.
Mercury Menace: Unraveling Accumulation and Impact in China's Southern Lakes: A Mini Review
Authors: Wang Yang , Ma Yang
Published: November 2024

This review explores mercury pollution in China's southern lake region, focusing on its accumulation in aquatic plants and the resulting ecological and human health impacts. Mercury's transformation within ecosystems disrupts biodiversity and food webs, posing significant environmental threats. Human exposure, primarily through contaminated fish, leads to serious health risks. The review highlights future research directions, including advanced detection technologies, phytoremediation strategies, and the influence of climate change on mercury dynamics. Emphasizing the need for improved risk assessments and effective policy frameworks, the article advocates for interdisciplinary approaches to mitigate mercury pollution. By integrating scientific innovation and community engagement, sustainable management and protection of both ecosystems and human health can be achieved.
Partidos políticos locales en Hidalgo: creación y permanencia en la competencia electoral
Authors: Hernández López Jovany
Published: November 2024

La conformación de partidos políticos locales, y la participación ciudadana hidalguense a través de estos, denotan un binomio en el cual, la interacción entre ambas figuras, resulta tener connotaciones que facilitan la posibilidad de creación, y de manera simultánea, desafíos para la permanencia de los primeros, en más de un proceso electoral, de tal forma que resulta relevante identificar las distintas aristas en el caso local del estado de Hidalgo, que se ha registrado desde el último proceso electoral local de renovación de ayuntamientos en 2020, en el que participaron por primera vez en su historia. A través de la presente investigación se busca, en un primer momento, describir el contexto nacional en el que compiten los partidos políticos locales frente a los partidos políticos nacionales, y la posibilidad, no sólo de mantener el registro, sino de ser un actor con posibilidades reales de ocupar cargos de elección popular. En un segundo momento, se pretende analizar el contexto partidista local del estado de Hidalgo; ya que, en 2018, se conformaron los primeros dos partidos políticos locales, y en 2019, derivado de la pérdida del registro nacional de dos partidos políticos, se sumaron dos nuevos partidos políticos locales, dando con ello un total de 4 partidos políticos locales. En este sentido, es necesario describir la normativa, el proceso y los resultados electorales de los mismos como consecuencia del apoyo o desafecto ciudadano.
AI-ACCIDENT-EYE
Authors: Kulkarni Mayuresh
Published: November 2024

Due to the sheer rise in vehicle accidents, there is an increasing demand for effective early vehicle crash detection and alert systems. We propose a vehicle crash detection system with sophisticated components such as raspberry pi, sensors, APIs, web browser automation and communication modules to improvise vehicle crash detection performance. The existing concept presents extreme Gradient Boosting, a Machine Learning approach for identifying accidents utilizing a set of real time data. Working on this method considering single dataset such as upstream and downstream averages, results in a lower efficiency. While most existing vehicle crash detection systems depend on single modal data, our proposed vehicle crash detection system uses an ensemble machine learning model based on multi modal data such as accelerometer, gyroscope, and shock sensor data. In order to verify that an accident has happened, a message is sent to the user, if the user does not respond to the call within 30 seconds, our detection system immediately conveys the exact location of the accident occurred to the nearest hospital within 82 seconds via voice message. Also another voice message enclosing the information about the location of the accident along with the hospital name will be sent to the trusted person specified by the user. The experimental results indicate that the proposed vehicle crash detection system performs significantly better than single classifiers. With the help of this application, we preserve the state of humanity and generate harmony in our society.
TREATMENT OF COMMINUTED MANDIBULAR FRACTURE WITH CLOSED REDUCTION AND MANDIBULAR FIXATION VERSUS OPEN REDUCTION AND INTERNAL FIXATION
Authors: Al-Rahbi Lutf Mohammed , Gamel Mohammed Ali Mohammed Fathael , Al-Shamahy Hassan Abdulwahab , Al-Ashwal Ahmed Abdulah
Published: November 2024

Background and aims: Injuries from firearms remain a serious public health concern, contributing significantly to our society's morbidity, mortality, and costs. Securing an airway, controlling bleeding, determining other injuries, and conclusively repairing the traumatic facial abnormalities are the four primary phases in the care of patients with gunshot wounds to the face. This study aimed to compare the effects of two treatment approaches for mandibular gunshot injuries: closed reduction and maxillomandibular fixation (MMF) against open reduction and internal fixation.
Methods: Between 2020 and 2023, mandibular fractures were found in two equal groups at the Military Hospital in Sana'a, Yemen, where the Department of Oral and Maxillofacial Surgery conducted the study. Twenty patients in group A received treatment by closed reduction and maxillo-mandibular fixation, and another twenty patients in group B received treatment by open reduction and internal fixation. Then complications following surgery were studied. Every patient had made a follow-up call between the second and eighth weeks; following the surgery, both groups' cases of postoperative infection, malocclusion, non-union or malunion of fracture fragments, facial asymmetry, exposed plates, and bone resorption were recorded and assessed radiographically and clinically.
Results: The study analyzed patients with mandible fractures, focusing on G.S.I. and bomb explosions. Most injuries occurred in the body, with parasymphsis being the most common site. Bone exposure was prevalent in 95% of patients. After a two-week follow-up, the ORIF treatment method was associated with more post-operative complications than the CR-MMF treatment method. Wound contraction was more common in the ORIF group (22.5%), followed by bone loss (15%). Plate exposure, nonunion, and malunion were more prevalent in the ORIF group.
Conclusions: In comparison to open reduction with internal fixation, it was determined that closed reduction is the most efficient and dependable management strategy for treating comminuted fractures of the mandible brought on by gunshot injuries. It also has a lower rate of complications.
                 
Peer Review History:
Received 18 July 2024;   Reviewed 13 September 2024; Accepted 20 October; Available online 15 November 2024
Academic Editor:  Dr. A.A. Mgbahurike, University of Port Harcourt, Nigeria, amaka_mgbahurike@yahoo.com
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Dr. Adebayo Gege Grace Iyabo, University of Ibadan, Nigeria, funbimbola@gmail.com
Dr. Ahmed Mohammed Al-Haddad, Hadhramout University, Al-Mukalla, Yemen, ahmedalhaddad@yahoo.com
COMPARATIVE OF PIEZOELECTRIC AND CONVENTIONAL OSTEOTOMY FOR LOWER THIRD MOLAR IMPACTION EXTRACTION WITH SUBMUCOSAL DEXAMETHASONE INJECTION
Authors: Senan Sohaib Ezzi Dhaif Allah , Farhan Abdullah HT , Shareef Ala،a Ahmed M , Al-Shamahy Hassan Abdulwahab
Published: November 2024

Background and aim: The most common procedure performed in the outpatient setting in maxillofacial surgery practices is the extraction of impacted third molars. This technique often requires incision, flap reflection, and bone removal, which causes tissue stress and involves large amounts of connective tissue and blood vessels in the third molar area. The aim of this study was to examine decompression surgery and the rotary technique alone and to evaluate the combined effect of decompression surgery and conventional osteotomy with submucosal dexamethasone injection on the sequelae after surgical extraction of impacted mandibular third molars.
Methodology: With a sample of sixty individuals, a randomized controlled clinical trial was carried out. Four groups of fifteen participants each were created: Group 1 was for conventional rotatory therapy; Group 2 was for conventional rotatory therapy plus a 4 mg dose of dexamethasone following surgery; Group 3 was for piezosurgery; and Group 4 was for piezosurgery plus a 4 mg dose of dexamethasone following surgery. The surgical working time was determined in minutes, the maximum mouth opening was measured in millimeters at baseline and on the second, fifth, and seventh day using a Vernier Caliper, and the postoperative pain was quantified using a Visual Analog Scale (VAS) every day for the first week.
Result: A study involving 36 women and 24 men aged 21-32 years performed a procedure involving impacted lower third molars, with a 100% success rate. All patients showed soft tissue healing without serious events or infection. Pain levels were greater in group 3 (3.7 degrees) and lower in group 2 (2.6 degrees). No significant differences were found in pain levels of dexamethasone injection among the four groups.
Conclusion: The use of submucosal dexamethasone injection with conventional and electrosurgical osteotomy is beneficial for alleviating post operative complication after removal of impacted third molar surgery.
                         
Peer Review History:
Received 11 July 2024;   Reviewed 17 September 2024; Accepted 23 October; Available online 15 November 2024
Academic Editor: Dr. Ali Abdullah Al-yahawi, Al-Razi university, Department of Pharmacy, Yemen, alyahawipharm@yahoo.com
Average Peer review marks at initial stage: 5.5/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Dr. Ahmad Abdelsattar El-Ebiary, Tanta University Hospitals, Tanta, Egypt, a.ebiary@med.tanta.edu.eg
Dr. George Zhu, Tehran University of Medical Sciences, Tehran, Iran, sansan4240732@163.com
THE CURRENT TRENDS OF PSORIASIS TREATMENT IN DERMATOLOGICAL PRACTICE
Authors: Abuarij Mutaia , Alyahawi Ali , Alkaf Ali
Published: November 2024

Psoriasis is associated with many complications. The severity of the disease can range from mild or moderate to severe. Treatment for this condition should be long-term and multifaceted, and may change over time based on the condition severity. Treatment for patients with psoriasis often includes treatment of the underlying pathophysiology. Other treatments for psoriasis include topical medications, phototherapy, and medications (nonspecific/biologic and biologic). Pharmacologic therapy is generally guided by disease severity and impact on patient quality of life, ranging from topical medications to phototherapy and, when necessary, systemic medications. However, challenges remain, including side effects, poor treatment, high costs, and variability in individual responses. Recent biologics have proven effective in psoriasis; on the other hand, there are differences among these drugs such as mechanisms of action, duration of response, and side effects. Biologics are often used to treat moderate to severe psoriasis and can be the treatment of choice, particularly in patients with comorbidities such as psoriatic arthritis or in whom psoriasis treatments such as methotrexate or cyclosporine are contraindicated. Different types of therapy are often used in combination. Combined therapies may improve treatment. Clinical guidelines classify psoriasis as mild or mild to severe, with mild lesions managed locally and moderate to severe lesions managed systemically.
                 
Peer Review History:
Received 8 July 2024;   Reviewed 11 September 2024; Accepted 17 October; Available online 15 November 2024
Academic Editor: Dr. Marwa A. A. Fayed, University of Sadat City, Egypt, maafayed@gmail.com
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Dr.  Murtaza M. Tambuwala, Ulster University, Ireland, m.tambuwala@ulster.ac.uk
Dr. Nada Farrag, Misr International University, Egypt, Nada_Hazem87@hotmail.com
HYBRID HYDROGELS INCORPORATING NANOPARTICLES, THEIR TYPES, DEVELOPMENT, AND APPLICATIONS: A COMPREHENSIVE REVIEW OF NANOGELS
Authors: Nadeem Ayesha , Saqib Zarqa , Arif Arooj , Abid Laraib , Shahzadi Huzaima , Saghir Arisha , Khan Esha , Afzaal Tahreem , Saadat Shanza , Rasheed Namra , Mustafa Muhammad Abid , Iqbal Muhammad Zahid
Published: November 2024

Nanogels have become significant in biomedical science research due to various unique characteristics. Hydrogels are three-dimensional crosslinked polymer networks that swell by absorbing aqueous solvents. These polymeric networks with sizes from nanometers to micrometres incorporate features of both hydrogels and nanoparticles, exhibiting high efficiency in drug delivery, tissue engineering, and biosensing. The synthesis process involves the chemical and physical crosslinking process, and the nanoparticles can be incorporated either during gelation or in situ. The resulting hydrogel nanoparticle composites exhibit high drug encapsulation capacity, adjustable swelling behaviour, biocompatibility, and responsiveness to stimuli like pH, temperature, and enzymes. They are of uniform size and less toxic, ideal for controlled and targeted drug delivery, and improved therapeutic effectiveness. Newer developments have highlighted its applications in cancer therapy, cardiovascular treatment, wound healing, and neurodegenerative disease management. This review provides a comprehensive analysis of the types of nanogel, the development process and wide-ranging applications, along with insights into future developments in this promising field.
                  
Peer Review History:
Received 6 July 2024;   Reviewed 11 September 2024; Accepted 19 October; Available online 15 November 2024
Academic Editor: Dr. Tamer Elhabibi, Suez Canal University, Egypt, tamer_hassan@pharm.suez.edu.eg
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.5/10
Reviewers:
Dr. Mohsen Ali Al-Hamzi, Thamar University, Factuality of Dentistry, Yemen. mohsenalhamzi@gmail.com
Md. Monirul Islam, Department of Pharmacy, Faculty of Health Sciences, Northern University Bangladesh, Dhaka, Bangladesh.  monirul.islam@nub.ac.bd
RECRIA INTENSIVA A PASTO (RIP) NA BOVINOCULTURA: Revisão narrativa de literatura
Authors: Nunes Victor Jordão Pimentel , Rodrigues Fernando Miller Sousa , Vieira Paulo Rufino Paulino
Published: November 2024

IPR (Intensive Pasture Rearing) is a supplementation program carried out with animals in the rearing phase, allowing them to enter the fattening phase in less time. IPR can reduce the production cycle, in addition to accelerating cash flow and increasing the number of cattle per hectare, allowing for a reduction in reproductive and slaughter age. This study consisted of basic research with a qualitative approach with a descriptive objective, using the narrative literature review method, collecting scientific articles and theses found in Google Scholar databases being carried out from October 2023 to May 2024. The IPR protocol proves to be an effective way of raising cattle that allows the producer to reduce production costs by maintaining animals with good body weight gain and shortening the rearing phase, which associated with good genetic selection, it can lead to reproductive precocity in the herd. However, as it is a recent technique, more studies are needed to demonstrate the effects of IPR on animal nutrition and the reproductive cycle of cattle.
ABORDAGENS TERAPÊUTICAS NO TRATAMENTO ESTÉTICO DE ESTRIAS: Uma revisão da literatura
Authors: Oliveira Paula Eduarda de Camargos , Ferreira Lílian de Abreu
Published: November 2024

Stretch marks are common skin lesions in the field of aesthetics that can cause psychological distress and anxiety in affected individuals due to their disfiguring appearance on the skin, especially in women, in addition to causing burning and itching when they appear on the skin. Their etiology is currently unknown and risk factors include family history, excessive weight gain, pregnancy, diseases and chronic use of corticosteroids. The abdomen, breasts, buttocks and thighs are the most predisposed areas to the appearance of stretch marks. The objective of the study was to review the most recent literature on the most commonly used and new treatment modalities and to analyze the critical points and difficulties in the treatment of stretch marks in recent years. A qualitative narrative review of the literature was carried out through a search for articles published in Portuguese and English limited to the last 5 years in the CAPES journal database and Google Scholar. The treatment modalities found in the studies were diverse and included everything from topical treatments to laser and LED procedures, microneedling, chemical peels, carboxytherapy, radiofrequency, and other more invasive therapies such as filler injections. Among the treatment modalities that have been explored so far, the therapeutic targets broadly include increasing collagen production, reducing vascularization, increasing pigmentation, and increasing pigmentation. It was possible to conclude that there is still no “gold standard” for the treatment of stretch marks, although all single treatment modalities showed significant improvement in the appearance of stretch marks, making the skin firmer and more elastic. In general, the combination of modalities is clinically more effective than isolated therapies, but their choice should be carefully defined in each case.
ORGANIZAÇÃO DA DEMANDA EM SAÚDE BUCAL E A VULNERABILIDADE FAMILIAR: Revisão narrativa da literatura
Authors: Ribeiro Karina de Fátima da Silva , Ribeiro Mariane Fernandes
Published: November 2024

This article aims to present the importance of oral health in people's lives as well as in the context of the Unified Health System (SUS) and highlight the relevance of this public health system for the low-income population in Brazil. Brazil has a significant portion of the population living in a situation of socioeconomic vulnerability, and oral health is essential for people's general well-being and quality of life. During this research, the relevance of public policies in the area of oral health will be presented. It will be emphasized that many oral pathologies are considered public health problems due to their high prevalence and severity, as well as the impact that these pathologies have on people's lives. The research used the hypothetical-deductive method with bibliographical research and literature analysis that deals with the perspective of oral health in Brazil with a focus, as already mentioned, on populations in situations of economic vulnerability. At the end of the research, it was found that having effective public policies aimed at meeting oral health demands is of fundamental importance for promoting human dignity, as well as for citizens' quality of life. However, unfortunately, Brazil does not guarantee universal access for its population in a state of social vulnerability.
Modelo de predicción para la extensión de la vida productiva en registros censurados de ganado Holstein de México
Authors: Nuñez-Soto Sandra Giovanna , García-Ruíz Adriana , Toledo Alvarado Hugo Oswaldo , Ruiz-López Felipe de Jesús
Published: November 2024

El objetivo de este estudio fue predecir los meses en producción a los 84 meses de edad (MEP84) para incluir información de animales aún vivos en la evaluación genética de longevidad a partir de información productiva y reproductiva para establecer la longevidad completa como MEP84. Los registros se obtuvieron de animales nacidos entre 1986 y 2020 de la asociación Holstein de México. Para predecir MEP84, se ajustó un modelo de regresión lineal para el 1er parto, al 2do, al 3º, al 4º y al 5º parto antes de 84 meses de edad. El modelo incluyó información de las vacas con longevidades completas como la producción de leche en kilogramos ajustada a 305 días EM (PE) en el parto actual, los meses en producción acumulados previos al parto actual (MACL), los meses en producción en el parto actual (MLPA), el índice de gestación en el parto actual (IDG), el índice del estado de la lactación en el parto actual (EDL) y la edad al primer parto en meses (EPP) en su efecto lineal y cuadrático (EPP2). El modelo explicó del 44 al 98 % de la variación observada en MEP84. La mayoría de los coeficientes de regresión para expandir las longevidades fueron significativos y positivos (P<0.01). La media del coeficiente para IDG fue negativo en todos los partos (-0.7159 ± 0.0171 y -2.0632 ± 0.0732). El modelo propuesto permitió incluir a vacas que aún no terminan su vida productiva, siendo de interés en las evaluaciones genéticas de longevidad.