bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessing quantitative EEG spectrograms to identify non‐epileptic events
Authors: Goenka Ajay , Boro Alexis , Yozawitz Elissa
Published: August 2019

Aims. To evaluate the sensitivity and specificity of quantitative EEG (QEEG) spectrograms in order to distinguish epileptic from non‐epileptic events.

Methods. Seventeen patients with paroxysmal non‐epileptic events, captured during EEG monitoring, were retrospectively assessed using QEEG spectrograms. These patients were compared to a control group of 13 consecutive patients (ages 25‐60 years) with epileptic seizures of similar semiology. Assessment of raw EEG was employed as the gold standard against which epileptic and non‐epileptic events were validated. QEEG spectrograms, available using Persyst 12 EEG system integration software, were each assessed with respect to their usefulness to distinguish epileptic from non‐epileptic seizures. The given spectrogram was interpreted as indicating a seizure if, at the time of the clinically identified event, it showed a visually significant change from baseline.

Results. Eighty‐two clinically identified paroxysmal events were analysed (46 non‐epileptic and 36 epileptic). The “seizure detector trend analysis” spectrogram correctly classified 33/46 (71%) non‐epileptic events (no seizure indicated during a clinically identified event) vs. 29/36 (81%) epileptic seizures (seizure indicated during a clinically identified event) (p=0.013). Similarly, “rhythmicity spectrogram”, FFT spectrogram, “asymmetry relative spectrogram”, and integrated‐amplitude EEG spectrogram detected 28/46 (61%), 30/46 (65%), 22/46 (48%) and 27/46 (59%) non‐epileptic events vs. 27/36 (75%), 25/36 (69%), 25/36 (69%) and 27/36 (75%) epileptic events, respectively.

Conclusions. High sensitivities and specificities for QEEG seizure detection analyses suggest that QEEG may have a role at the bedside to facilitate early differentiation between epileptic seizures and non‐epileptic events in order to avoid unnecessary administration of antiepileptic drugs and possible iatrogenic consequences.
Atonic seizures in children with surgically remediable epilepsy: a motor system seizure phenotype?
Authors: Scholly Julia , Bartolomei Fabrice , Valenti‐Hirsch Maria Paola , Boulay Clotilde , De Saint Martin Anne , Timofeev Alexander , Kehrli Pierre , Hirsch Edouard
Published: August 2019

Aim. Atonic seizures are common in some epileptic syndromes beginning in infancy or early childhood but they are rarely described in epilepsy with focal seizures of structural aetiology. We aimed to characterize the electroclinical features of atonic seizures in surgically remediable paediatric patients and to study the spatiotemporal organization of the underlying epileptogenic networks.

Methods. We retrospectively analysed two consecutive, longitudinally evaluated and surgically treated paediatric patients presenting with atonic seizures as a manifestation of pharmacoresistant epilepsy of structural aetiology, evidenced by scalp‐ and stereotactic intracerebral video‐EEG‐recordings. A quantitative analysis of the epileptogenic zone organization was performed using the “epileptogenicity index”.

Results. Long‐lasting generalized ictal atonia, occurring in infancy, was a predominant clinical feature in both patients, with some hints of focal origin present in one case. The seizure phenotype evolved at later age into subtle segmental atonia, associated with prominent positive motor signs. The epileptogenic zone was localized within the dorsolateral or mesiolateral premotor region. Its spatial organization was focal, matching the lesional cortex in one and distributed involving several lesional and non‐lesional structures in the other case. The emergence of atonic semiology temporally correlated with involvement of both lateral and mesial premotor, as well as primary motor areas.

Conclusion. We hypothesize that atonic seizures may be considered as a motor system seizure phenotype in the setting of structural epilepsy. Complete removal of the epileptogenic area provided excellent seizure control.
Exceptional response to brivaracetam in a patient with refractory idiopathic generalized epilepsy and absence seizures
Authors: Grande‐Martín Alberto , Sopelana‐Garay David , Pardal‐Fernández José Manuel , Sánchez‐Honrubia Rosa María , Sánchez‐Larsen Álvaro Abelardo
Published: August 2019

Brivaracetam is currently indicated as adjunctive therapy for patients with focal‐onset seizures with or without secondary generalization. However, it has been suggested that it could provide broad‐spectrum efficacy given its similarity to levetiracetam and based on the results from preclinical studies and others of patients with generalized epilepsy. We present the case of a woman with refractory idiopathic generalized epilepsy and absence seizures with dramatic response to brivaracetam. Our report supports a consideration of treatment with this new antiepileptic drug on a case‐by‐case basis in patients with refractory generalized epilepsy, while we await further studies on this topic.
Sleep‐related hypermotor epilepsy activated by rapid eye movement sleep
Authors: Wang Xiaoli , Marcuse Lara V , Jin Lang , Zhang Ying , Zhang Wenjuan , Chen Beibei , Yuan Na , Wang Bi , Liu Yonghong
Published: August 2019

Most sleep‐related seizures occur during non‐rapid eye movement (NREM) sleep, particularly during stage changes. Sleep‐related hypermotor epilepsy (SHE) is a rare epileptic syndrome characterized by paroxysmal motor seizures, mainly arising from NREM sleep. Here, we report a patient with SHE who had seven seizures captured on video‐EEG‐polysomnography during REM sleep. Ictal semiology of this patient ranged from brief paroxysmal arousals to hypermotor seizures. On EEG‐polysomnography, the spontaneous arousals were more frequent during REM than NREM sleep, with a considerably higher arousal index in REM sleep (20/hour). While the reason for seizures during REM sleep in this patient is unclear, we speculate that the threshold and mechanisms of arousal during different sleep stages may be related to the occurrence of seizures. [Published with video sequences on www.epilepticdisorders.com].
Ictal spitting in non‐dominant temporal lobe epilepsy: an anatomo‐electrophysiological correlation
Authors: Quevedo‐Diaz Marcos , Campo Adrià Tauste , Vila‐Vidal Manel , Principe Alessandro , Ley Miguel , Rocamora Rodrigo
Published: August 2019

We report a patient presenting drug‐resistant, non‐dominant temporal lobe epilepsy with ictal spitting and prosopometamorphopsia, both extremely rare semiologies. Second‐phase pre‐surgical monitoring was performed using SEEG due to lesion‐negative imaging and the rare semiology. The seizure onset zone was delimited to the right anterior hippocampus and the temporobasal cortex, with the propagation zone within the entorhinal cortex. Interestingly, direct electrical stimulation to the entorhinal cortex, which was reproduced in a number of trials, evoked spitting without leading to seizures or post‐discharges. After the resection of the epileptogenic zone, the patient remained seizure‐free without AEDs for a follow‐up period of five years (Engel Class 1a). The neuropathology revealed a focal cortical dysplasia type FCD‐Ia. Spectral analysis of intracranial ictal EEG (iEEG) data suggested a possible role of the basal temporal and entorhinal cortex as a necessary node in ictal spitting. [Published with video sequences onwww.epilepticdisorders.com].
Electroclinical and radiological observation of dysfunctional zones in a patient with neurosyphilis
Authors: Sakai Katsuya , Yazawa Shogo , Sugimoto Akiko , Nakao Koichi , Tsuruta Kazuhito , Ochiai Eiji , Suzuki Yukiko , Matsuhashi Masao
Published: August 2019

We report a 33‐year‐old Japanese man who suffered from repetitive generalized tonic‐clonic seizures which were medically intractable. Neurosyphilis was serologically diagnosed in blood and cerebrospinal fluid, and penicillin G (PcG) was consequently effective. The EEG during PcG pre‐treatment showed frequent right occipital spikes and right frontocentral slow waves, which disappeared after treatment. During pre‐treatment, positron emission tomography with 18‐fluorodeoxyglucose and Tc‐99m ethyl cysteinate dimer single‐photon emission computed tomography revealed occipital hypermetabolism and hyperperfusion (“hot” area) and fronto‐temporo‐parietal hypometabolism and hypoperfusion (“cool” area) over the right hemisphere. The spike sources of magnetoencephalography during pre‐treatment were localized to “hot” areas, and the slow activities were distributed to the fronto‐temporo‐parietal region, corresponding to “cool” areas. The inflammatory seizure focus and reversible dysfunctional zone associated with neurosyphilis were clearly delineated using these techniques.
Atypical postictal transient subcortical T2 hypointensity in a newly diagnosed diabetic patient with seizures
Authors: Paoletti Matteo , Bacila Ana , Pichiecchio Anna , Farina Lisa Maria , Rognone Elisa , Cremascoli Riccardo , Fanucchi Simona , Manni Raffaele , Bastianello Stefano
Published: August 2019

Common postictal MRI findings include transient cortical T2 hyperintensity, restricted diffusion, and gyral and/or adjacent leptomeningeal contrast enhancement. In certain uncommon pathological conditions, other signal abnormalities can be present, suggesting a different underlying pathogenic mechanism. We report the case of a 66‐year‐old man, recently diagnosed with diabetes mellitus type 2, presenting with new‐onset visual and auditory hallucinations, “absence” seizures, and repeated peaks of hyperglycaemia without hyperketonaemia or increased serum osmolarity. EEG confirmed epileptic discharges in the right temporal region and MRI showed vast subcortical T2 hypointensity in the right temporal lobe, without any cortical hyperintensity, restricted diffusion, or contrast enhancement. Subcortical signal abnormality and EEG discharges resolved after a month of follow‐up, with a small juxtacortical gliotic focus as a sequela. Peaks in hyperglycaemia have been reported to be responsible for T2 hypointense subcortical abnormalities through a proconvulsant mechanism linked to increased ketone body concentrations. Hyperosmolarity and hyperketonaemia were not evident in this case, however, transient accumulation of free radicals that alter the intercellular space can be considered the presumable cause of this finding. In summary, it is important to consider any unusual findings on postictal MRI in order to avoid errors in interpretation.
A comparison between the 1981 and 2017 International League Against Epilepsy classification of seizure types based on an outpatient setting
Authors: Gao Hui , Sander Josemir W. , Xiao Yingfeng , Zhang Yingying , Zhou Dong
Published: August 2019

Aim. To compare between the 1981 and 2017 International League Against Epilepsy (ILAE) classification of seizure types based on an outpatient setting.

Methods. We retrospectively reviewed 200 patients from our outpatient epilepsy registry. Based on clinical information, their seizure types were classified according to ILAE official reports, and differences between the 1981 and 2017 classifications were compared. All unclassifiable cases based on either one or both classification systems were discussed.

Results. The 200 patients had a total of 243 manifestations. Some terms in the 2017 classification clearly correspond to those of the 1981 classification, while others lack clarity and are more controversial. The three most frequently encountered seizure types based on the 2017 classification were focal to bilateral tonic‐clonic (83; 34.1%), unknown‐onset tonic‐clonic (56; 23.0%), and focal impaired awareness (52; 21.4%). Based on the 1981 classification, the three most frequently encountered seizure types were unclassified (89; 36.6%), secondary generalized tonic‐clonic (sGTCS) (83; 34.1%), and complex partial (CPS) (36; 14.8%). Seventy‐five of 89 (84.3%) unclassified cases based on the 1981 classification were classified using the 2017 classification mainly due to the addition of the “unknown origin” category and a combination of different levels of terms (level of awareness and motor/non‐motor features). In 14 cases, seizures were unclassifiable using both classification systems; eight were rare manifestations with unclear awareness or unusual bilateral movements and six were due to a lack of detailed description.

Conclusion The 2017 seizure classification greatly reduces the number of unclassifiable cases. The combination of awareness level and motor/non‐motor features introduces greater flexibility and allows for detailed seizure description. Several cases, however, remain unclassified, but these are mostly due to a lack of understanding of epilepsy. The 2017 seizure classification demonstrates a steady transition from the 1981 classification with acceptable consistency and improvements.
Probable dysimmune epilepsia partialis continua manifesting as epileptic moving toes syndrome: electroclinical features of a challenging case
Authors: Brigo Francesco , Vogrig Alberto , Bratti Arianna , Tavernelli Veronica , Nardone Raffaele , Trinka Eugen
Published: August 2019

Epilepsia partialis continua (EPC) is a rare form of focal status epilepticus. We describe a 22‐year‐old woman with EPC manifesting with isolated toe movements, prevalent over the left side and initially misdiagnosed as psychogenic, clinically almost indistinguishable from those observed in “painful legs and moving toes syndrome”. The continuous involuntary movements with EMG correlates of twitches lasting <100 ms, the sharp waves over fronto‐central regions on EEG, and the marked asymmetry in somatosensory evoked potentials with higher cortical amplitude over the right side following peripheral stimulation over the left foot confirmed the epileptic nature of the symptoms, leading to the diagnosis of EPC. The toe movements were markedly reduced following steroid therapy, whereas the infusion of immunoglobulins caused aseptic meningitis. Despite an extensive diagnostic work‐up (including a search for antibodies for paraneoplastic and autoimmune encephalitis), an ultimate aetiological diagnosis was not reached, although the dramatic response to corticosteroids strongly supported an underlying dysimmune pathophysiology. Diagnosing EPC can be challenging, especially if movements are confined to a very small body region or strongly resemble movements encountered in other conditions. EEG‐EMG monitoring should be performed in patients with continuous involuntary muscular jerks in order not to overlook a diagnosis of EPC. [Published with video sequences onwww.epilepticdisorders.com].
Genetic literacy series: genetic epilepsy with febrile seizures plus
Authors: Myers Kenneth A. , Scheffer Ingrid E. , Berkovic Samuel F. ,   on behalf of the ILAE Genetics Commission
Published: August 2019

Genetic epilepsy with febrile seizures plus (GEFS+) is a familial epilepsy syndrome in which affected individuals within a family typically have a variety of epilepsy phenotypes, varying from simple febrile seizures and febrile seizures plus with a good outcome to severe epileptic encephalopathies. Here, we review the spectrum of epilepsy phenotypes, the genetic architecture of GEFS+, and the implicated genes. Using an illustrative clinical case study, we describe important steps in managing patients with GEFS+: making the diagnosis of GEFS+, appropriate genetic testing, and counselling.
Inadequate benzodiazepine dosing may result in progression to refractory and non‐convulsive status epilepticus
Authors: Rao Shishir Keekana , Mahulikar Advait , Ibrahim Mohammad , Shah Aashit , Seraji‐Bozorgzad Navid , Mohamed Wazim
Published: August 2019

Aims. Status epilepticus (SE) is defined as ongoing seizures lasting longer than five minutes or multiple seizures without recovery. Benzodiazepines (BZDs) are first‐line agents for the management of SE. Our objective was to evaluate BZD dosing in SE patients and its effects on clinical/electrographic outcomes.

Methods. A retrospective analysis was conducted from a prospective database of SE patients admitted to a university‐based neurocritical care unit. The initial presentation and progression to refractory SE (RSE) and non‐convulsive SE (NCSE) with coma was evaluated. Outcome measures included length of stay (LOS), rates of intubation, ventilator‐dependent days, and Glasgow outcome scale (GOS). The lorazepam equivalent (LE) dosage of BZDs administered was calculated and we analysed variations in progression if 4 mg or more of LE (adequate BZDs) was administered.

Results. Among 100 patients, the median dose of LE was 3 mg (IQR: 2–5 mg). Only 31% of patients received adequate BZDs. Only 18.9% of patients with NCSE without coma received adequate BZDs (p=0.04). Among patients progressing to RSE, 75.4% had not received adequate BZDs (p=0.04) and among patients developing NCSE with coma, 80.6% did not receive adequate BZDs (p=0.07). Escalating doses of BZDs were associated with a decrease in cumulative incidences of RSE (correlation coefficient r=‐0.6; p=0.04) and NCSE with coma (correlation coefficient r=‐0.7; p=0.003). Outcome measures were not influenced by BZD dosing.

Conclusion. The majority of our patients were not adequately dosed with BZDs. Inadequate BZD dosing progressed to RSE and had a tendency to lead to NCSE with coma. Our study demonstrates the need to develop a hospital‐wide protocol to guide first responders in the management of SE.
Electroclinical history of a five‐year‐old girl with GRIN1‐related early‐onset epileptic encephalopathy: a video‐case study
Authors: Pironti Erica , Granata Francesca , Cucinotta Francesca , Gagliano Antonella , Efthymiou Stephanie , Houlden Henry , Salpietro Vincenzo , Di Rosa Gabriella
Published: August 2019

De novo mutations in the GRIN1 gene have been recently reported as the molecular cause of a broad‐spectrum early‐onset neurological phenotype. Here, we describe a five‐year‐old girl with an early‐onset epileptic encephalopathy associated with an infantile hyperkinetic movement disorder and oculomotor abnormalities. Whole‐exome sequencing identified a novel p.Met641Leu de novo variant in the GRIN1 gene as the cause of the phenotype. In silico analysis suggested that the p.Met641Leu variant would alter the gating property of the ion channel, with the involved methionine residue facing towards the ion pore. Long‐term systematic video‐EEG allowed us to report on the electroclinical history and, specifically, on the semiology of the hyperkinetic movement disorder and oculomotor abnormalities resembling oculogyric crises in our patient. Our findings and a review of the recent literature reinforce the notion of GRIN1‐encephalopathy as a recognizable neurological phenotype that should be suspected in early‐onset epilepsy associated with hyperkinetic movement disorders. [Published with video sequence on www.epilepticdisorders.com]
Refractory epilepsy secondary to anti‐GAD encephalitis treated with DBS post SEEG evaluation: a novel case report based on stimulation findings
Authors: Gillinder Lisa , Lehn Alexander , Papacostas Jason , Olson Sarah , Blum Stefan , Dionisio Sasha
Published: August 2019

We report a case of medically refractory anti‐GAD encephalitis which was treated with deep brain stimulation (DBS) after seizure termination was achieved using cortical stimulation during stereo‐electroencephalography (SEEG) evaluation. The patient underwent bilateral SEEG implantation and cortical stimulation. Upon stimulation, mimicking the intrinsic seizures (at 1 Hz), it was possible to induce seizures with typical semiology, on multiple attempts. Stimulation during these seizures with high frequency (50 Hz) resulted in complete termination of the seizure. DBS was inserted after the SEEG evaluation, targeting the bilateral anterior nucleus of the thalamus. There was a sustained reduction in seizure frequency and severity 12 months post insertion. There were also improvements in quality of life. To the best of our knowledge, this is the only case reported in which DBS was successfully used to treat refractory epilepsy in a patient with seizures that were proven to be responsive to electrical stimulation during SEEG recording.
The natural history of nodding syndrome
Authors: Idro Richard , Ogwang Rodney , Kayongo Edward , Gumisiriza Norbert , Lanyero Agnes , Kakooza‐Mwesige Angelina , Opar Bernard
Published: August 2019

Aims. Nodding syndrome is a poorly understood acquired disorder affecting children in sub‐Saharan Africa. The aetiology and pathogenesis are unknown, and no specific treatment is available. Affected children have a distinctive feature (repeated clusters of head nodding) and progressively develop many other features. In an earlier pilot study, we proposed a five‐level clinical staging system. The present study aimed to describe the early features and natural history of nodding syndrome and refine the proposed clinical stages.

Methods. This was a retrospective study of the progressive development of symptoms and complications of nodding syndrome. Participants were a cohort of patients who had been identified by community health workers and were referred for treatment. A detailed history was obtained to document the chronological development of symptoms before and after onset of head nodding and a physical examination and disability assessment performed by a team of clinicians and therapists.

Results. A total of 210 children were recruited. The mean age at the onset of head nodding was 7.5 (SD: 3.0) years. Five overlapping clinical stages were recognised: prodromal, head nodding, convulsive seizures, multiple impairments, and severe disability stages. Clinical features before the onset of head nodding (prodromal features) included periods of staring blankly or being inattentive, complaints of dizziness, excessive sleepiness, lethargy, and general body weakness, all occurring two weeks to 24 months before nodding developed. After the onset of head nodding, patients progressively developed convulsive seizures, cognitive and psychiatric dysfunction, physical deformities, growth arrest, and eventually, in some patients, severe disability.

Conclusions. The description of the natural history of nodding syndrome and especially the prodromal features has the potential of providing a means for the early identification of at‐risk patients and the prompt initiation of interventions before extensive brain injury develops. The wide spectrum of symptoms and complications emphasises the need for multi‐disciplinary investigations and care.
Intractable apnoeic seizures in a child with a deletion typically associated with Williams syndrome
Authors: Jan Saber , Ochi Ayako , Kagawa Kota , Gill Peter , Guttmann Astrid , Otsubo Hiroshi , Kobayashi Jeff
Published: August 2019

Williams‐Beuren syndrome is rarely associated with epilepsy. One previously reported case showed an association with apnoeic seizures while a few other cases showed an association with infantile epileptic spasms and generalized and focal seizures. We report the case of a 13‐month‐old boy with a deletion typically associated with Williams‐Beuren syndrome, who presented with isolated apnoeic seizures which were refractory to multiple antiepileptic drugs but partially responsive to the ketogenic diet. The diagnosis was challenging due to a complex cardiac history, gastroesophageal reflux, and normal interictal EEG findings. This case highlights the importance of prolonged EEG monitoring in suspected cases of apnoeic seizures. Further, given the reported cases of unexplained sudden death in Williams‐Beuren syndrome, this case raises the possibility of an association between apnoeic seizures and unexplained sudden death. [Published with video sequence on www.epilepticdisorders.com]
Juvenile absence epilepsy relapsing as recurrent absence status, mimicking transient global amnesia, in an elderly patient
Authors: Muccioli Lorenzo , Licchetta Laura , Stipa Carlotta , Tinuper Paolo , Bisulli Francesca
Published: August 2019

We describe a 68‐year‐old woman who had typical absence seizures since 14 years of age. The absences were refractory to treatment and persisted into adulthood, with no seizure‐free periods until seizure control at 59 years of age. After six years of being seizure‐free, she presented with an episode characterized by mental confusion, abnormal behaviour, and amnesia, lasting for several hours. An EEG performed the day after, when the patient had already recovered, was unremarkable. The episode was interpreted as transient global amnesia. After two and three years, respectively, she presented with two analogous episodes lasting >24 hours. An EEG disclosed, on both occasions, subcontinuous generalized spike‐and‐wave discharges, consistent with absence status epilepticus (AS). The last episode occurred at 68 years of age and was successfully treated with intravenous lorazepam. After one month of follow‐up, no further episodes occurred.

AS is common in juvenile absence epilepsy, however, our patient showed a rather atypical course, characterized by refractory and persistent absences during adolescence and adulthood, and a tendency for AS to recur with no more absences in later life. Despite the known epilepsy history, AS episodes were initially misdiagnosed. Moreover, EEG recording and subsequent treatment were not performed until the second day of status.
Hemiconvulsion‐Hemiplegia‐Epilepsy in a girl with cobalamin C deficiency
Authors: Myers Kenneth A. , Dudley Roy WR. , Srour Myriam
Published: August 2019

Hemiconvulsion‐Hemiplegia‐Epilepsy initially involves an infantile presentation of febrile focal motor status epilepticus, with subsequent hemiplegia of the initially affected side. Months to years later, affected children go on to develop a chronic epilepsy with recurrent focal seizures which are often refractory to treatment. This uncommon paediatric epilepsy syndrome is poorly understood, with only a very small minority of cases associated with an underlying genetic or metabolic abnormality.

We present a four‐year‐old girl with genetic cobalamin C deficiency who had a dramatic presentation with Hemiconvulsion‐Hemiplegia‐Epilepsy. She had febrile focal status epilepticus, with right hemiconvulsive seizures for nearly 10 hours, ultimately requiring a midazolam infusion. Over subsequent days, she developed progressively worsening cerebral oedema, leading to herniation and requiring a craniectomy to relieve pressure.

This girl's presentation is the first association of cobalamin deficiency with hemiconvulsion‐hemiplegia‐epilepsy; and illustrates the importance of considering this entity when patients with this metabolic disorder present with acute deterioration. More importantly, the case also raises the possibility that derangements of cobalamin metabolism could be a contributing factor in cases of hemiconvulsion‐hemiplegia‐epilepsy, as well as febrile seizures in general.
Marcial Prado (2001): Diccionario de falsos amigos. Inglés-español, Madrid, Gredos
Authors: Aguilar Lourdes
Published: August 2019

Reseña: Marcial Prado (2001): Diccionario de falsos amigos. Inglés-español, Madrid, Gredos.
El disfraz de democracia en la bruma espesa del totalitarismo neoliberal
Authors: Ríos-Alvarado Arnaldo
Published: August 2019

El “fantasma de la medición” para el proceso de “indización” se pasea por las universidades colombianas a la caza de los esfuerzos editoriales, todavía hoy incipientes, en las llamadas revistas “científicas”, supeditadas a índices “objetivos” de citación donde ser editor se ha convertido en una maldición. La relación ciencia “visible” y calidad “se mide ahora por el número de citaciones de una publicación, con el agravante que cada vez se escribe más y se lee menos. “Quienes se quedaron con un lugar en el mundo de los que compiten por los puntos seguirán siendo medidos y entenderán que la clasificación de las revistas tiene el sentido final en la clasificación de los investigadores, quienes en adelante portarán letras capitales virtuales adheridas a sus nombres y a sus títulos y pertenecerán a un sistema de castas, al estilo colonial, pero con A1, A2, B, C y el resto. Pero esto último no será ajeno a su práctica cotidiana de exclusiones, pendencias y silenciamientos” (Suarez, 2017, p.14). Por esto uno de los problemas centrales para abordar y reflexionar es el asunto de la ética y su relación con la pasión de la actividad editorial. ¿A donde nos llevara el camino que nos están marcando y que dócilmente hemos emprendido por el miedo a perder la indexación?
DIREITO, ECONOMIA E DESENVOLVIMENTO: DO DESMONTE DA CONSTITUIÇÃO DIRIGENTE DE 1988 A “COMMONLIZAÇÃO” DO DIREITO BRASILEIRO
Authors: Bazzanella Sandro Luiz , Albuquerque Camila L. Nandi de
Published: August 2019

O presente artigo reflete as implicâncias entre direito, economia e desenvolvimento diante do acelerado do ideário neoliberal sobre o Estado brasileiro. A exigências da economia financeirizada global de desregulamentação e da flexibilização do Estado de bem-estar social estabelecido pela constituição de 1988, impedem a consolidação de um projeto de desenvolvimento nacional, bem como reduzem o Estado a uma agência garantidora do livre mercado e, dos contratos de remuneração da economia financeirizada. E neste contexto, a Constituição de 1988, elaborada na perspectiva de uma constituição dirigente do projeto de desenvolvimento nacional foi submetida à constantes reformas em seu texto constitucional. Trata-se de adequá-la as exigências da lógica de mercado. E neste contexto, o direito vai se adequando as demandas de legalidade desta (des)ordem requeridas pelo capital, nas formas mais evidentes da judicialização da política e do ativismo judicial.
The Effect of Perinatal Fish Oil Supplement on Perinatal Depression: A Systemic Review and Meta- Analysis of Randomized Clinical Trials
Authors: S Helman , RB Baker , M Hassan , T Nafee , J Yang , V Vuddanda
Published: August 2019

Background: Perinatal depression is a common complication of pregnancy and can have severe and long-termadverse effects on both mother and infant. Randomized controlled trials (RCT) assessing the effect of fish oilsupplements on perinatal depression have shown mixed results.Objectives: We performed a systematic review and meta-analysis to assess the effects of fish oil supplementation during pregnancy on perinatal depression.Methods: A comprehensive search of MEDLINE (PubMed), EMBASE, and Cochrane Central Registry were conducted in adherence with the PRISMA guideline. Only RCTs published in English from January 2000 to date were included. The participants were pregnant women receiving fish oil supplementation or placebo. Summary effect measure of each study was converted to a common effect measure (log odds ratio) and its variance was calculated to estimate the pooled odds ratio and its 95% confidence Interval using random Effects model. Heterogeneity was assessed used restricted maximum likelihood method.Results: Nine trials were included in our analysis (2,979 women). Prevention Cohort (n = 5): Fish oil supplementation during pregnancy was associated with reduced risk of developing perinatal depression (OR: 0.87; CI: 0.076 to 0.99; p = 0.03). Treatment Cohort (n = 4) Fish oil supplementation during pregnancy was associated with reduced risk of persistent perinatal depression during postpartum period but did not reach statistical significance.Conclusion: In conclusion, a meta-analysis of included RCTs data shows a significant reduction in incidences of perinatal depression in women who received fish oil supplements during pregnancy. However, there was no evidence for a similar effect among women diagnosed with perinatal depression or women with major depressive disorder.
Forecasting of the Generation of Municipal Solid Waste in Large Cities
Authors: Mikhailova N.V. , Yasinskaya A.V.
Published: August 2019

Using the example of a forecast developed for St. Petersburg, an analysis was made of typical problems and nuances for Russian megalopolises that should be taken into account when predicting the volume of municipal solid waste (MSW). A statistical method is described that is recommended for a long-term forecast of the generation of MSW in the Russian Federation. The results of waste generation forecasting in St. Petersburg until 2030 are given. Recommendations are given on improving statistical accounting in the field of municipal solid waste management.
Recycling of Ceramic and Polymeric Wastes in the Production of Surfacing Composite Materials
Authors: Torlova A.S. , Vitkalova I.A. , Pikalov E.S. , Selivanov O.G.
Published: August 2019

Presents the results of research on the development of a method for joint utilization of polystyrene foam and brick waste with obtaining a polymer composite material for the production of wall cladding products. This method consists in grinding the waste polystyrene foam with their subsequent dissolution in carbon tetrachloride and cold mixing the resulting solution with a crushed brick. This method reduces the energy intensity of production, eliminates thermal decomposition of the polymer binder during processing and makes it possible to jointly dispose of two types of large-tonnage waste. Products that can be obtained from the developed material, according to the values of frost resistance and water absorption, meet the requirements for products for external facing of walls and sole plates of facades.
Justification of Measures to Reduce the Health Risk from Air Pollution by Suspended Particles Less than Ten Micrometers (PM10) on the Urban Road Network
Authors: Trofimenko Yu.V. , Chizhova V.S.
Published: August 2019

A method for assessing the risk of air pollution by suspended particles smaller than ten micrometers (PM10) on the street road network (SRN) of the large city is presented. It includes an assessment of the intensity of the release and distribution in air of PM10, the sources of which are exhaust gases from vehicles with diesel engines, tire wear, and road surface wear. An assessment is made of the chronic and carcinogenic risk to public health from exposure to PM10 in the air in a roadside area. Substantiated measures to reduce the risk to public health from PM10 air pollution in the SRN.
Engaging Faculty in Learning Analytics: Agents of Institutional Culture Change
Authors: Rehrey George , Shepard Linda , Hostetter Carol , Reynolds Amberly Maurine , Groth Dennis
Published: August 2019

To successfully implement Learning Analytics (LA) systems within higher education, we need to engage administrators, faculty, and staff alike. This paper is by and primarily for practitioners. We suggest implementation strategies that consider the human factor in adopting new technologies by analyzing the viability of our Learning Analytics Fellows Program (LAFP), where faculty are empowered as agents of institutional change. This program directly addresses known barriers to the use of LA, dealing with culture management, adoption, and sustainability. The Fellows program engages faculty in inquiry about student success, providing them with a view of the student experience through institutional data. Faculty, with their knowledge of students and programs as well as their research expertise, are well-positioned to advance LA efforts on our campuses. In our case, faculty are also the end users of their findings, and are able to provide input into the design of the analytical tools created for them. Expanding on a paper presented at the LAK 18 conference (Rehrey, Groth, Fiorini, Hostetter, & Shepard, 2018), we describe the rationale for the implementation strategy, reflect on the effectiveness of this strategy by analyzing self-reports from our LAFP, and consider the broader impacts of this approach for the future.
Creative Thinking in Qualitative Research and Analysis
Authors: Konecki Krzysztof T.
Published: August 2019

I would like to present the possibility of broadening the traditional methodological and technical skills of researcher and analyst, but also the intellectual capacity of the researcher associated with combining data, categorizing, linking categories, as well as the interpretation of the causes and consequences of the emergence of certain social phenomena. Some methodologies, methods, and research techniques are more conducive to creative conceptual and interpretive solutions. Therefore, I describe the serendipity phenomenon in such methodologies as grounded theory, ethnography, phenomenological research, and contemplative inquiry. The problem of intuition in qualitative research will be also described in the paper. There will be presented also some suggestions how to be creative in qualitative research. From the review of issues of creativity in qualitative research we can derive the following conclusions: Creativity in qualitative research depends on the strength of a priori conceptualization and stiffness of the adapted methods of research and analysis. If the methodology is more flexible (as the methodology of grounded theory), the researcher can get to phenomena that he/she has not realized and which are still scantily explored in his/her field of expertise. The phenomenological and contemplative approaches allow the use of the investigator’s feelings and experience as they appear in the studied phenomena, which usually does not take place in objectifying and positivistic research. The investigator may therefore consciously use these methodologies and approaches that foster creativity. The researchers can improve their skills in thinking and creative action by doing some methodical exercises (journal writing, writing poetry as a summary of the collected data, the use of art as representation of the phenomenon, the use of meditation, observation of the body feelings, humor, etc.).
Practice and challenges in provision of guidance and counselling services in secondary schools of South Gondar, Ethiopia
Authors: Kelkay Asrat Dagnew
Published: August 2019

The main purpose of the study was to assess the provision of guidance and counselling service in South Godar secondary schools. It was designed to study the types of service provided by service providers in South Gondar secondary schools and to investigate the attitude and awareness of Guidance & Counselling Committee (GCC) members, teachers, principals and students towards the usefulness of guidance and counselling services/programme. The study was conducted using a descriptive survey design from five secondary schools using questionnaires and interview as data gathering instruments. The total number of sampled respondents was 173, of which 100 (students) selected by simple random sampling, five school principals, 49 teachers, 19 GCC members/service providers were selected using comprehensive sampling technique. Statistical data analysis techniques were used to analyse the data and thematic analysis, i.e., qualitative analysis, was used to interpret interview and open-ended questionnaires. The study revealed that most of the secondary school service providers were provided behavioural and academic counselling and educational counselling for their students in their respective schools. The study also indicated that positive attitude and promising awareness towards guidance and counselling service among the four category respondents.

Keywords: Challenges, counselling guidance, practice and secondary school.
Status of counselling services in secondary schools in Keren sub-zone, Anseba Region, Eritrea
Authors: Andegiorgis Ghebrehiwet Eyasu
Published: August 2019

The purpose of the study was to assess status of counselling services in secondary schools in Keren sub-zone, Anseba region, Eritrea. The research was anchored on Social Learning Theory of Albert Bandura. The study used convergent parallel mixed method research design. Questionnaires and interview guide were used to collect the data. A sample of 306 students, 20 teachers, 5 head masters, 5 teacher counsellors were used for this study. Systematic sampling, simple random and purposive sampling were used to select the schools and the participants. The validity and reliability of the instruments was guaranteed by piloting and Cronbach Alpha technique. Data gathered through questionnaires were processed using descriptive statistical techniques involving frequencies, percentages and means. The results were then presented using tables, pie charts and bar graphs. Data gathered through interview guides were analysed and presented using quotes, themes and narrative descriptions. The findings of the study showed that counselling was minimally used in the secondary schools in Keren subzone. Majority of students, 57.6% and teachers, 75% reported that their schools did not have counselling service.

Key words: Counselling services, status, students, counsellor, teacher, head teachers.
ATRAKSI BARONGSAI: DARI KLENTENG KE MALL” SEBUAH FENOMENA DESAKRALISASI SIMBOL RITUAL AGAMA
Authors: Sani Amilda
Published: August 2019

Dimana melihat ekspresi simbol-simbol agama di Indonesia? Maka jawabannya adalah Mall. Mall adalah ruang publik dimana setiap individu dapat mengaksesnya secara bebas dan memberi makna terhadap segala ekspresi yang muncul di ruang tersebut, salah satunya adalah diberikannya ruang untuk munculnya simbol-simbol keagamaan dengan tujuan yang sama yaitu komersialisasi dengan tujuan menarik keuntungan.
The Effect of Problem Based Learning to Critical Thinking Ability of M1 Students in Plant Biotechnology Materials
Authors: Choiriya Iir Nur , Narulita Erlia , Chuseng Areerat
Published: August 2019

This study aimed to determine the effect of learning based on learning problems on students' critical thinking skills in plant biotechnology materials. This research is a quasi-experimental type using the design of "Post test and pretest, Non Equivalent Control Group Design" which consists of two experimental classes. The first experimental class used the Problem Based Learning learning model and the second class used a discussion learning model. Problem-based learning motivates students to learn independently to find information themselves from various sources, such as the environment, media and the internet. This learning trains students to think critically about contextual problems related to the material so as to improve students' cognitive abilities ranging from identifying problems, formulating hypotheses, analyzing problems, evaluating and concluding.
O indígena e a cidade
Authors: Batistoti Aleida Fontoura , Latosinski Karina Trevisan
Published: August 2019

Este artigo aborda a presença indígena, majoritariamente da etnia Terena, na área urbana de Campo Grande/MS, perpassa seu processo de migração e aprofunda-se nos principais signos existentes nas Aldeias Urbanas (AUs) deste município. Objetivou-se analisar as condições de vida, as habitações e demandas dessas AUs como forma de caracterizar a presença do indígena no espaço ur bano e contribuir cientificamente com a temática. Assim, foram avaliadas seis aldeias conforme sua realidade de criação (contexto histórico e implantação urbana) e atual estado de conservação (tipo de moradias e necessidades da comunidade). Logo, identificou-se que a migração dos indígenas se dá principalmente pela busca de qualidade de vida e oportunidades, além da efetivação e criação de políticas públicas que os contemple, já que o cenário atual é de precariedade e exclusão físico-social, dissonante com a cultura desse povo.
Apresentação
Authors: Rua
Published: August 2019

Abrimos o ano de 2019 com muitas e variadas publicações que nos animam, em termos de política científica, a insistir na abertura de espaços como este que a Revista Rua proporciona. Neste volume 25, as análises são de múltiplas áreas com lugares teóricos distintos e recortes analíticos bem diversos.
Modelling wine astringency from its chemical composition using machine learning algorithms
Authors: Sáenz-Navajas Maria P , Ferrero-del-Teso Sara , Romero Miguel , Pascual Darío , Diaz David , Ferreira Vicente , Fernández-Zurbano Purificación
Published: August 2019

Aims: The present work aims to predict sensory astringency from wine chemical composition using machine learning algorithms.Material and results: Moristel grapes from different vineblocks and at different stages of ripening were collected. Eleven different wines were produced in 75 L tanks in triplicate, and further sensory factors were described by the rate-all-that-apply method with a trained panel of participants. The polyphenolic composition was characterised in wines by measuring the concentration and activity of tannins using UHPLC-UV/VIS, the mean degree of polymerisation (mDP. and the composition of tannins using thiolysis followed by UHPLC-MS. Conventional oenological parameters were analysed using FTIR and UV-Vis. Machine learning was applied to build models for predicting a wines astringency from its chemical composition. The best model was obtained using the support vector regressor (radial kernel) algorithm presenting a root-mean-square error (RMSE) value of 0.190.Conclusions: The main variables of the astringency model were the % of procyanidins constituting tannins and ethanol content, followed by other eight variables related to tannin structure and acidity.Significance of the study: These results increase the knowledge of chemical variables related to the perception of wine astringency and provide tools to control and optimise grape and wine production stages to modulate astringency and maximise quality and the consumer appeal of wines.
UPAYA MENINGKATKAN HASIL BELAJAR IPS SISWA KELAS 7.2 SMPN 3 MALANG MELALUI MODEL STUDENT TEAM ACHIEVEMENT DIVISION (STAD) PADA MATERI PENDUDUK INDONESIA DAN PEMANFAATAN SUMBER DAYA ALAM
Authors: Suriyanto Suriyanto
Published: August 2019

Tujuan penelitian ini adalah untuk meningkatkan hasil belajar IPS Siswa kelas 7.2 semester 2 SMPN 3 Malang pada materi Penduduk Indonesia dan Pemanfaatan Sumber Daya Alam melalui penerapan model pembelajaran kooperatif tipe Student Teams Achievement Division. Hasil penelitian menunjukkan bahwa ada peningkatan hasil belajar sebelum dan sesudah menggunakan model pembelajaran tipe STAD dengan ditunjukan data sebagai berikut. Ketuntasan belajar sebelum pra tindakan yaitu sebesar 60% kemudian siklus I meningkat 63,33%, dan siklus II meningkat menjadi 80%.
PENGARUH TINGKAT PENDIDIKAN DAN PENDAPATAN ORANG TUA TERHADAP PRESTASI BELAJAR IPS SISWA KELAS VIII DI MTS AZZAINIYAH I RANDUMERAK KECAMATAN PAITON KABUPATEN PROBOLINGGO TAHUN AJARAN 2013/2014
Authors: Solehoddin Solehoddin
Published: August 2019

Pendidikan di sekolah merupakan suatu usaha untuk membantu siswa dalam perkembangan sesuai dengan bakat dan kemampuan anak. Tingkat keberhasilan dari masing-masing anak banyak dipengaruhi oleh beberapa faktor antara lain faktor latar belakang keluarga, tingkat pendidikan, dan tingkat pendapatan orang tua yang mempengaruhi prestasi belajar siswa. Metode penelitian yang digunakan dalam penelitian ini adalah metode data primer yang berupa angket dan dan sekunder yang berupa rapot siswa semester I mata pelajaran IPS kelas VIII Di MTs Azzainiyah I Randumerak,Kecamatan paiton Kabupaten Probolinggo Tahun pelajaran 2013/2014 .berdasarkan hasil penelitian didapatkan dan setelah diadakan analisis data diperoleh rhitung (X1) sebesar 0,759 dan rhitung (X2) sebesar 0,617 sedangkan thitung (X1) sebesar 0,035 dan thitung (X2)sebesar 0,011. Sedangkan  Fhitung sebesar 0,000  dan kontribusi efektif dari kedua variabel tingkat pendidikan dan tingkat pendapatan orang tua tersebut sebesar 62,9%. terhadap prestasi belajar dan sisanya sebesar 37,1%.dari kesimpulan di atas ada pengaruh yang positih dan signifikan antara pendidikan dan pendapatan orang tua terhadap prestasi belajar siswa.