bluuebunny/crossref_metadata_2025 huggingface dataset:
Isolated 17,20-Lyase Deficiency in a CYB5A Mutated Female With Normal Sexual Development and Fertility
Authors: Leung Mei Tik , Cheung Hoi Ning , Iu Yan Ping , Choi Cheung Hei , Tiu Sau Cheung , Shek Chi Chung
Published: November 2019

Isolated 17,20-lyase deficiency may be caused by mutations in the CYP17A1 (coding for cytochrome P450c17), POR (coding for cytochrome P450 oxidoreductase) and CYB5A (coding for microsomal cytochrome b5) genes. Of these, mutations in the CYB5A gene have thus far only been described in genetic males who presented with methemoglobinemia and 46,XY disorders of sex development (DSD) due to 17,20-lyase deficiency.

A 24-year-old Chinese woman presented to the hematology outpatient clinic with purplish discoloration of fingers, toes, and lips since childhood. Investigations confirmed methemoglobinemia. A homozygous c.105C>G (p.Tyr35Ter) nonsense mutation was detected in the CYB5A gene. Hormonal studies showed isolated 17,20-lyase deficiency. Interestingly, she had a completely normal female phenotype with no DSD, normal pubertal development, and spontaneous pregnancy giving birth uneventfully to a healthy female infant.

The sex hormone-related features of genetic females with 17,20-lyase deficiency due to cytochrome b5 gene mutation appear to differ from that of females with 17,20-lyase deficiency caused by other genetic defects who presented with hypergonadotropic hypogonadism and infertility and differ from genetic males with the same mutation.
Three by Three: Lisa Cholodenko’s Attachment Trilogy
Authors: Wallace Lee
Published: November 2019

Lisa Cholodenko’s three films High Art (US, 1998), Laurel Canyon (US, 2002), and The Kids Are All Right (US, 2010) all tell the same story: a sexual and emotional ingenue arrives in a tightly circumscribed social world that both resembles and departs from a conventional family. At its heart is an established couple whose seemingly secure erotic bond is marked by deep ambivalence. This bond is stretched beyond recognition as it bends to the presence of the sexual outsider, who is first incorporated into, then ejected from, the pseudofamilial world. Though irreparably altered, the established couple survives—and may even be strengthened by—the sexual, spatial, and professional infidelity that forms the central plot of the film. No longer disavowed, the ambivalence that has marked the couple’s formation from the outset is now under-stood to be fundamental to their ongoing attachment. Whether the relationships are straight, gay, or bisexual; maternal, paternal, or filial; motivated, situational, or opportunistic; whether the worlds they inhabit are those of art photography, popular music, or medicine; whether their compulsions are addictive, obsessive, or narcissistic; the common story is basically the same, as is the lesson that attends it: attachment is always ambivalent. That is part of its satisfaction. End of story. Or, begin again. This article invokes Stanley Cavell’s classic account of the Hollywood comedy of remarriage in order to place Cholodenko’s trilogy within a wider popular conversation about attachment and ambivalence in the era of marriage equality.
Opening Statements: Theme Singing and Shifting Paradigms for Voicing Feminine Subjectivities as Television Music
Authors: Vesey Alyxandra
Published: November 2019

This article argues that more scholarly attention should be paid to women’s contributions to the practice of “theme singing,” or the textual and industrial practices of using vocalists as sonic proxies for television characters by articulating programs’ thematic concerns and embodying their tonal dimension in television shows’ credit sequences and soundtracks. Though vulnerable to muting and time shifting, female recording artists—and black women in particular—have always been a fixture of US television production by helping build televisual worlds as theme singers. These professionals help cultivate television programs’ aural sensibilities by literally giving voice to a show’s premise and, in so doing, raise the volume on women’s place in television storytelling as otherwise marginalized subjects. This essay identifies three different types of theme singing that are especially common in television storytelling: theme singing as declaration of selfhood, theme singing as expression of kinship, and theme singing as assertion of community. Further, it analyzes Solange’s and SZA’s involvement with Insecure (HBO, 2016–) as music consultant and soundtrack contributor, respectively, to identify an emerging pattern within contemporary television production of shifting the tonal and thematic properties of theme singing onto licensing by dispensing with original theme music altogether while potentially amplifying more women’s voices as source music.
Patterns of formation of spinal inhibition in humans
Authors: Челноков Андрей , Chelnokov Andrey , Городничев Руслан , Gorodnichev Ruslan
Published: November 2019

The monograph is devoted to the study of age-related features of presynaptic, recurrent, non-reciprocal and reciprocal inhibition of the human spinal cord. New data on the formation of structures and functions of the spinal cord, peripheral nervous system, skeletal muscles in pre - and postnatal ontogenesis are summarized. Modern data on presynaptic, recurrent, nonreciprocal and reciprocal inhibition in the Central nervous system are presented. The original methodological techniques adapted by the authors for the study of various types of inhibition in the human spinal cord are presented. The age stages of formation and formation of different types of spinal inhibition in humans are described, age-related features of inhibitory processes in the implementation of arbitrary motor activity are analyzed.
The monograph is intended for neurophysiologists, pediatricians, specialists in the field of age physiology, teachers of pedagogical, sports and medical universities.
Imaginary Points in Cartesian Coordinate System
Authors: Гирш А. , Girsh A. , Короткий Виктор , Korotkiy Viktor
Published: November 2019

Geometric models are considered that allow symbolic representation of imaginary points on a real Cartesian coordinate plane XY. The models are based on the fact that through every pair of imaginary conjugate points A~B with complex coordinates x = a ± jb, y = c ± jd one unique real line m passes. For the image of imaginary points, it is proposed to use the graphic symbol m{OL} consisting of the line m passing through the imaginary points, the center O of the elliptic involution σ with imaginary double points A~B on the line m, and the Laguerre point L, from which the corresponding points involutions σ are projected by an orthogonal pencil of lines. According to A.G. Hirsch, the symbol m{OL} is called the marker of imaginary conjugate points A~B. A theorem is proved that establishes a one-to-one correspondence between the real Cartesian coordinates of the points O, L of the marker, and the complex Cartesian coordinates of the pair of imaginary conjugate points represented by this marker. The proved theorem allows us to solve both the direct problem (the construction of a marker depicting these imaginary points) and the inverse problem (the determination of the Cartesian coordinates of imaginary points represented by the marker). A graphical algorithm for constructing a circle passing through a real point and through a pair of imaginary conjugate points is proposed. An example of the graph-analytical determination of the Cartesian coordinates of imaginary points of intersection of two conics that have no common real points is considered.
A Mathematical Description of the Rotation of a Point Around an Elliptic Axis in Some Special Cases
Authors: Антонова И. , Antonova I. , Беглов И. , Beglov I. , Соломонова Е. , Solomonova E.
Published: November 2019

Previously, we developed a constructive method for modeling surfaces of rotation with axes, which were second-order curves such as circle, ellipse, parabola and hyperbola [1]. We also described the principle of constructing a mathematical model [23] corresponding to this constructive technique [2], and expressed the method in mathematical form. In this paper, we applied the previously developed mathematical model that allows us to determine the trajectory of rotation of a point around an elliptical axis to some special cases of the location of this point and identified the features of each of them. We applied the previously accepted terminology and the system of designating points, straight and curved lines involved in the search for circular trajectories of rotation of points. We analyzed the cases of the location of the generating point on the coordinate axes. We determined in mathematical form the trajectory of the point located in these positions. This entry is represented as systems of parametrically given equations. The article also describes a step-by-step algorithm used to find the equation of a circle, which is the trajectory of rotation of a point around an elliptic axis. We applied this algorithm to various positions of the generating point relative to the elliptic axis foci. We applied the previously developed criteria for selecting near and far centers of rotation relative to one of the focuses of the ellipse. The results of these mathematical studies will be used in the future to create a computer program capable of generating digital 3D-models of surfaces formed by the rotation of arbitrary sets forming points around the curves of the axes of the second order.
The Effect of Physical Activities on Physical Education Learning Outcomes
Authors: P Eva Julianti , Dlis Firmansyah , Asmawi Moch
Published: November 2019

This study aimed to find the effect of physical activity on academic performance of physical education. The research method used in this research is quantitative approach, survey method with test and measurement technique. The population of the research was students at a public secondary school in East Jakarta, and 216 students of 6 classes grade eight participating in this research. There is a positive influence of physical activity on student learning outcome of physical education. Physical activity has a direct positive effect on learning outcomes of physical education. This means that increasing physical activity will lead to an increase in physical education learning outcomes. Implication of the present study is that efforts can be made to improve learning outcomes physical education through structured physical activity, by providing physical activities, games and sports chosen to achieve educational goals.
Influence of mineral water of well No. 3 of Semyanivka village of Poltava district of Poltava region (Ukraine) on the structural and functional state of the kidneys with experimental nephritis
Authors: Gushcha S. , Nasibullin B. , Zukow W. , Balashova I. , Koieva К. , Volyanska V. , Arabaji M.
Published: November 2019

In an experiment on white rats with toxic nephritis, pathological changes in the structural and functional state of the kidneys were determined. An increase in the daily diuresis (p <0.001) was found, due to an increase in the glomerular filtration rate by (p <0.001) and a significant decrease in the percentage of fluid back-suction (p <0.001). The excretion of creatinine and urea increased by (p <0.01), and the excretion of chloride ions, on the contrary, decreased (p <0.01). Application on the background of the development of low-mineralized silicon chloride-hydrocarbonate sodium water leads to partial normalization of kidney function - the volume of diuresis is moderately restored by increasing the tubular reabsorption against the background of a significant increase in the glomerular filtration rate and a significant increase in the amount of silica. The manifestations of inflammation in the kidneys disappear, but the destructive changes of the nephrons remain. The partial restoration of the activity of redox enzymes has been established.
A GATA E O GATO SEM E COM BOTAS: OS CONTOS DE BASILE E DE PERRAULT PELO VIÉS DA INTERTEXTUALIDADE
Authors: Reis Adriana Aparecida de Jesus , Tommasello Ramos Maria Celeste
Published: November 2019

Estudo comparativo entre a narrativa maravilhosa, conhecida como “Cagliuso”, presente na obra Pentamerone, do italiano Giambattista Basile (1566-1632), e “Mestre gato ou o gato de botas”, do francês Charles Perrault (1628-1703), que, segundo Coelho (1991), foi inspirada na narrativa italiana de Basile, mas não existem comprovações históricas do contato do escritor francês com os textos do escritor italiano. Com base nas considerações de Darnton (1986), Mendes (2000) e Samoyault (2008), entre outros, verificamos os pontos em comum e as divergências para compreender se há bases para a afirmação de que o conto de Perrault seria uma releitura intertextual do conto de Basile.
A ERA DAS CARTAS: O DIÁRIO DA PROCURA DE COMPAGNON POR BARTHES
Authors: Di Sevo Rosa Dafne
Published: November 2019

Resenha do livro A era das cartas.
Apresentação Edição 30
Authors: Palimpsesto Revista
Published: November 2019

Apresentação Edição 30
O "ENTRE-LUGAR" DO DISCURSO DE SILVIANO SANTIAGO: UMA CONVERSA SOBRE LITERATURA E CULTURA COM O MESTRE
Authors: Palimpsesto Revista
Published: November 2019

Entrevista com o Prof. Silviano Santiago para o número 30.
The Care Quality Commission's factual accuracy check guidance: an update
Authors: Hart Anna
Published: November 2019

The 10-day period allowed to providers for comment on the factual accuracy of draft reports is a critical phase. The recent changes to this process are easily missed, but may mean a difference between ratings. Anna Hart clarifies these small yet crucial updates to the regulatory guidance
Embracing the Cascade part 2: clinical decision making in equine gastric disease
Authors: Redpath Adam , Bowen Mark
Published: November 2019

Equine gastric disease, previously referred to as Equine Gastric Ulcer Syndrome (EGUS), is now defined as two distinct disorders. Equine Squamous Gastric Disease (ESGD) is a condition of the equine stomach that is predominantly ulcerative. Equine Glandular Gastric Disease (EGGD) describes the disease of the glandular mucosa, typically a non-ulcerative condition of the pyloric region of the stomach. Acid suppression is the mainstay of therapy for ESGD, and oral omeprazole is the only medication authorised for the management of gastric ulcers (i.e. ESGD), where it is generally effective. Alternative (unauthorised) agents are usually only considered where there is treatment failure, and histamine antagonists, other proton pump inhibitors, or long-acting injectable formulations may be useful in those situations. Management of EGGD requires the use of unauthorised medicines, since no medicines are authorised for its treatment. Misoprostol, long-acting injectable omeprazole and a combination of omeprazole with sucralfate have all been described in its management and can be justified in different clinical scenarios, under the prescribing cascade.
The Effect of Organic Waste Potential of Mersin and Adana Provinces on Biogas Energy Production
Authors: Yelmen B. , Cakir M.T.
Published: November 2019

In this study, the current state of organic wastes obtained from plant, animal, kitchen and industrial sewage sludge plants in Mersin and Adana provinces and biogas energy production potential were investigated. In this study, data on animals and plants were obtained from Adana and Mersin Provincial Directorate of Agriculture and data on kitchen and industrial wastes were obtained from Adana and Mersin Metropolitan Municipality. As a result of this study, the daily amount of organic matter produced in animal, vegetable, kitchen and sewage sludge plants in Mersin province is 16 801.48 tons and the amount of biogas produced from these wastes is 557 432.47 m3 and the electricity generated from methane is 2 619.93 MWh. It has been identified. In Adana province, the daily organic matter produced in animal, vegetable, kitchen and sewage sludge plants is 24 517.35 tons and the amount of biogas produced from these wastes is 637 882.68 m3 and the electricity generated from methane is 2 998.05 MWh. In Mersin, 33% of the electricity generated from organic wastes was obtained from treatment sludge, 57% from animal manure, 4% from agricultural waste and 6% from kitchen waste. In Adana, 39% of the electricity generated from organic wastes was obtained from treatment sludge, 36% from animal manure, 15% from agricultural wastes and 10% from kitchen wastes. Adana Province; In terms of organic matter produced in animal, vegetable, kitchen and sewage sludge plants, it is determined that it is approximately 19% more than Mersin province and it is about 7% more in terms of electrical energy produced from methane.
Antibiofilm Activity and Biocorrosion Control by Means of Essential Oil from Lippiagracilis Schauer (Verbenaceae) Microemulsion System
Authors: Viana Marcelino Gevilbergue , Lutterbach Márcia Tereza Soares , Albuquerque Cynthia Cavalcanti de , Da Silva Djalma Ribeiro , Diniz Jaécio Carlos , Fernandes Teixeira Ewerton Richard , Do Nascimento Santos Francisco Josiel , Dos Santos Everaldo Silvino
Published: November 2019

In this study the use of the essential oil from a Lippiagracilis Schauer micro emulsion system as a biocide and antibiofouling agent upon biofilms as well as the effect of this micro emulsion on the corrosion rate of AISI 1020 carbon steel was investigated. The results showed that a microemulsion type Winsor-IV was efficient in preventing the biofouling formation after 96 hours of contact and inhibited the growth of the sulfate reducing, iron-oxidizing bacteria as well as the fungi forming the biofilms after the 16 days of contact time. The antimicrobial action was likely due to a formation of a protective film.
R&D Portfolio Management: the case study of a big energy company in Brazil
Authors: Pfitzner Mariana Savedra , Carvalho Ruy de Quadros
Published: November 2019

DOI: http://dx.doi.org/10.13071/regec.2317-5087.2012.1.1.4038.74-94Portfolio Management entails the systematic evaluation, selection and prioritization of R&D projects in the organizational context. The aim of this article is to discuss the use of tools for managing the R&D portfolio in the Brazilian electricity sector, using the case study of an energy distribution company as an analytical support. In this sector, investment in research projects and guidelines for their completion are enforced by law. Otherwise, energy companies would not invest in R&D, they would rather buy equipment and systems from international suppliers. The execution of these projects is also strongly supervised by ANEEL, which guarantees that their results will turn into new products, patents, job creation, tariff reduction and operational efficiency for the company. If projects do not accomplish with government criteria, energy companies may be strongly penalized. In order to avoid such risk, companies may implement Portfolio Management tools.
Expediente
Authors: Santos Glicia Vieira dos
Published: November 2019

DOI: http://dx.doi.org/10.13071/regec.2317-5087.2012.1.1.4899.1-4Apresenta a edição de lançamento da Revista Gestão & Conexões (Management and Connections Journal), v1, n1, jul./dez. 2012.
Inovação em Serviços e sua Gestão: um balanço das teorias internacionais contemporâneas
Authors: Lenhari Luciana Cristina , Carvalho Ruy de Quadros
Published: November 2019

DOI: http://dx.doi.org/10.13071/regec.2317-5087.2013.2.2.4646.75-101O objetivo deste artigo é mostrar o atual estado da arte das discussões acerca do tema da inovação em serviços e sua gestão. Para atingir este objetivo o artigo apresenta uma revisão crítica da literatura com base nos principais autores que vêm se dedicando a esta discussão nos últimos 20 anos. Desta revisão resultou uma síntese de como o debate foi construído, seus principais avanços e gargalos, notadamente quando o foco é gestão da inovação. Conclui-se que o campo da gestão da inovação em serviços representa uma excelente oportunidade de pesquisa para os próximos anos, com espaço para a proposição de “novos” modelos que possam ser mais adequados para as empresas de serviços que atuam no contexto brasileiro.
Acessibilidade sob Diferentes Pontos de Vista: caminhos percorridos pelo pesquisador com deficiência visual
Authors: Arnais Magali Aparecida de Oliveira , Stadoan Diego de Bernardin , Zattera Vilson
Published: November 2019

DOI: http://dx.doi.org/10.13071/regec.2317-5087.2014.3.1.5051.92-106. As tecnologias evoluem em ritmo acelerado, no entanto a acessibilidade para as pessoas com deficiência visual ainda não está devidamente considerada no ambiente acadêmico. Este artigo objetiva apresentar relatos individuais, escritos a partir da percepção de dois alunos/pesquisadores com deficiência visual, usuários do Laboratório de Acessibilidade da Biblioteca Central Cesar Lattes da Universidade Estadual de Campinas (LAB/BCCL/Unicamp), como recurso para aprofundar o conhecimento sobre acessibilidade no ambiente acadêmico. Três aspectos no quesito acessibilidade são apontados por esses usuários: a arquitetônica, a comunicacional levando-se em conta o uso das novas tecnologias e a atitudinal. O aluno/pesquisador com deficiência visual no ensino superior aprende caminhos alternativos para atingir seus objetivos, aponta desde ações de políticas públicas na criação de instrumentos diferentes para uma mesma finalidade às atitudes pró ativas na construção do conceito de acessibilidade.
Towards a Decological Praxis
Authors: Nogueira-Godsey Elaine
Published: November 2019

Abstract in English

In this paper, I argue that social justice cannot be fully realized without affirming its intrinsic ties to environmental justice, and further that these ties point toward a ‘decological praxis.‘ Decological praxis is a truncation of decolonial ecological pedagogy. It is a praxis that I am crafting and one which I propose that those concerned with justice-oriented theological education can have in common, as it offers possibilities to partake in a progressively shared intersectional decolonial theological methodology. It is decolonial because this is a practice focused in training the mind to emancipate oneself, the other and nature from long-standing hierarchical patterns of power reproducing colonial modes of relationships. I propose that we use decological praxis as the orienting principle to teach, research and learn from each other's experiences of social and environmental injustice. I conclude by proposing that this praxis may result in a culture of decoloniality, which brings into light the need to investigate the effects of coloniality in our own, temporal and local, lived experiences and to do so via a process of deliberate self-reflexivity.

Key words: Environmental Justice, Ecofeminism, Theology, Coloniality, Decolonial Pedagogical Praxis.
The Mountain of Youth: Converting American Buddhism and the Authority of the Monk-Convert Paradigm
Authors: Baker Drew
Published: November 2019

Abstract English

This article examines generational shifts in popular narratives pertaining to dominant formations of Buddhism in the United States from 1950 to the 1990s through a postcolonial lens particularly sensitive to age, children, and family dynamics. A close read of Jack Kerouac's novels and the film Little Buddha identifies important features of this genealogy. This analysis shows that white Buddhist American converts' power and visibility have been reinforced by the Orientalist notion of a monk-convert lineage which presents the convert—represented as a free white young adult—as the sole heroic incarnation of the present and future of Buddhism in the modern world.

Key words: Buddhism, Conversion, Religion and Age, Orientalism
The Afterlives of Torture: The Global Implications of Reactionary US Politics
Authors: Hajjar Lisa
Published: November 2019

None
When push comes to shove: dynamics of unionising in the Israeli high-tech sector
Authors: Fisher Ben , Fisher Eran
Published: November 2019

This article examines the unprecedented unionising trend among Israeli hightech workers since 2014, based on a field study conducted during 2017-2018. It outlines the concrete constellations that made unionising possible, and the inner dynamics of unionising efforts. It identifies the roots of the trend, maps the different parties involved and analyses the interests, methods and practices that made unionising in this sector possible and even successful.
Influence of Fuel on Structure, Morphology, Magnetic Properties and
Photocatalytic Activity of NiFe2O4 Nanoparticles
Authors: Nguyen Loan T.T. , Nguyen Lan T.H. , Hang N.T.T. , Hai Nguyen Quang , Hau Vu Thi , Nguyen Duy Trinh , T. Dao To-Uyen
Published: November 2019

The present study attempted the synthesis of nickel ferrite (NiFe2O4) nanoparticles via solution combustion technique with urea as the fuel. The synthesized samples was structurally characterized by a series of different techniques including TGA/DSC, X-ray powder diffraction, energy dispersive X-ray, scanning electron microscope, transmission electronic microscopy, Brunauer-Emmett-Teller and Fourier transform infrared spectroscopy. A vibrating sample magnetometer (VSM) was also employed to investigate the magnetic properties of nickel ferrite at room temperature. The results showed that the crystallite size of the NiFe2O4 nanoparticles declined from 45.8 to 33.7 nm in response
to elevated amount of urea in the precursor. The photocatalytic activity of NiFe2O4 nanoparticles was investigated by using rhodamine B dye under visible light.
Synthesis, Molecular Docking and Antimicrobial Studies of Some Novel 1,4-Dihydropyridine Derivatives
Authors: Ashokkumar D. , Ramalingam G. , Gopalakrishnan M.
Published: November 2019

Three components one pot synthesis of some novel triazole substituted 1,4-dihydropyridine compounds from the simple condensation reaction of ethyl acetoacetate, 4-amino triazole and aromatic aldehyde has been demonstrated using on low cost and efficient acetic acid catalyst in solvent free condition followed by microwave irradiation method. The newly synthesized 1,4-dihydropyridine compounds exhibit in excellent yield. The synthesized dihydropyridine derivatives are screened for antimicrobial properties and molecular docking study.
The Politics of ‘Economic Inclusion’ in Canada: Past, Present, Prospects
Authors: Hale Geoffrey
Published: November 2019

Abstract

This article examines Canada’s relative success in restoring ‘economic inclusion’ and ‘inclusive growth’ between the political and economic disruptions of the 1990s and the mid-2010s. Noting competing views of the concept of ‘inclusion’, it explores four major factors which contributed to reducing domestic tensions during this period. These include the intentional accommodation of diverse regional interests through increased decentralization of Canadian federalism, the use of international trade policies to facilitate largely complementary regional economic policies, the restoration of fiscal sustainability in federal economic policies and to varying degrees across provinces, and the cultivation of cross-partisan consensus on immigration policies to avoid the social polarization experienced in other industrial countries. It concludes by noting areas of political vulnerability with the potential to disrupt this consensus.
Lipid peroxidation parameters and activities of lysosomal enzymes in diabetics
Authors: Chugunova L. G. , Dubinina I. I.
Published: November 2019

The processes of lipid peroxidation and activities of lysosomal enzymes were studied in 56 patients with type I and II diabetes mellitus. The rate of lipid peroxidation of red cell membranes was assessed from the activities of enzymatic (NADPH-dependent) and nonenzymatic (ascorbate-dependent) . lipid peroxidation, from accumulation of acylhydroperoxides, in- termolecular joints, and from spontaneous red cell hemolysis. Activities of lysosomal enzymes (cathepsines, acid DNAse, and P-galactosidase) were measured in leukoconcentrate. The activity of enzymatic system of lipid peroxidation and acylhydroperoxide content in red cell membranes were found increased. In parallel with this, a deficiency in leukocytic lysosomes of P-galactosidase and DNAse was revealed. The detected metabolic disturbances may be regarded as one of the pathogenetic mechanisms of development of diabetic angiopathies. A relationship was revealed between changes in lipid peroxidation parameters and activities of lysosomal enzymes, on the one hand, and diabetes mellitus type and duration, on the other.
Usage of plasmapheresis in combined therapy of diabetics
Authors: Sokolov Ye. I. , Podachina S. V. , Zabotnov V. I. , Zanina Ye. B.
Published: November 2019

Clinical observations have repeatedly proved that myocardial infarction in patients with diabetes mellitus (DM) is much more difficult, gives greater mortality, its complications such as acute heart failure, arrhythmia, and relapses are more often observed. The basis of the atherosclerotic process both in diabetes and without it, the main place is given to hyperlipoproteinemia (hypercholesterolemia, hypertriglyceridemia and hypoalpha-cholesterolemia). Most patients with severe type I diabetes mellitus (insulin-dependent, IDDM) and type II diabetes mellitus (non-insulin-dependent, NIDDM) showed an increase in plasma levels of low and very low density lipoprotein cholesterol (cholesterol-LDL and cholesterol-VLDL, respectively) and a decrease high density lipoprotein cholesterol (HDL-C; anti-atherogenic factor).

The use of lipid-lowering drugs for the correction of hyperlipoproteinemia in patients with diabetes is often ineffective or the effect obtained is short-term in nature, side reactions often develop. In recent years, in order to reduce the level of lipids in blood plasma (coronary heart disease, familial hypercholesterolemia, etc.), extracorporeal methods aimed at massive removal of the plasma lipid pool have begun to be used. According to the authors, the rapid and massive removal of atherogenic lipid fractions from plasma contributes to the release of the steroid from the tissue pool.

In the pathogenesis of the development of vascular complications in patients with IDDM and NIDDM, a significant place is given to dysfunction of erythrocyte membranes. Functional disorders are directly dependent on violations of the structure of membrane lipids. Changes in the structure of the lipid bilayer of the erythrocyte membrane in patients with diabetes contribute to increased microviscosity of membranes, reduced deformability, and hinder their passage through the microcirculation system, which can be the cause of tissue hypoxia and one of the links in the pathogenesis of angiopathy in patients with diabetes.

The aim of this work was to study the possible correction of the lipid spectrum of blood plasma and erythrocyte membranes in patients with diabetes when the plasmapheresis method is included in the complex therapy.
Prolactin and TSH secretion in functional tests in patients with primary hypothyroidism and hyperprolactinemia
Authors: Chernova T. O. , Kolesnikova G. S. , Mudretsova S. V. , Serpukhovitin S. Yu. , Goncharov N. P. , Goncharov G. A.
Published: November 2019

It was previously proposed that hyperprolactinemia in primary hypothyroidism is caused by enhanced release of hypothalamic TRH leading to elevation of both TSH and prolactin levels. Since the dopaminergic system is involved in regulation of prolactin and TSH secretion, we attempted to evaluate the origin of hyperprolactinemia in patients with primary hypothyroidism using tests with metoclopramide, a dopaminergic blocker (10 mg, i.v) and TRH. Two groups of patients were examined: 20 women with primary hypothyroidism and normal prolactin levels (group A) and 10 women with primary hypothyroidism and hyperprolactinemia (mean basal prolactin level 1514.8 + 300.8 mIU/ml). Prolactin reaction in metoclopramide test in group A was markedly increased vs. control group (1131 and 776%, respectively). In group В prolactin reaction in metoclopramide test was blurred (299%), similarly as in patients with microprolactinomas. We came to a conclusion that hyperprolactinemia in patients with primary hypothyroidism is unlikely to be caused by excessive TRH release, but possibly by the presence of subclinical microadenoma which manifests by the hypothyroid state or, possibly, by disturbed dopaminergic regulation of prolactin and TSH secretion in patients with primary hypothyroidism.
The content of gamma-aminobutyric acid and its synthesis enzyme activity in the blood plasma of children exposed to ionizing radiation because of the Chernobyl power plant accident
Authors: Bolshova Ye. K. , Mishunina T. M. , Malinovskaya T. N. , Kukhta I. N. , Samson O. Ya.
Published: November 2019

Marked individual fluctuations in blood levels of GABA and GDC revealed in 35 to 50% of adolescents exposed to ionizing radiation several years before indicate the presence of an imbalance in the GABA-ergic system. These children (with GABA- ergic system disturbances) represent a group at risk of developing remote effects of radiation exposure presenting as disturbed rhythms and terms of sexual maturation, of growth, thyroid and adrenal abnormalities, and they should be regularly checked up.
Triiodothyronin recepton in exposure to low-dose ionizing radiation
Authors: Nikolayeva L. A. , Danilova L. I. , Kholodova Ye. A.
Published: November 2019

Effects of ionizing radiation in doses 0.5 and 1 Gy on triiodothyronin reception by rat peripheral blood lymphocytes were examined 3, 10, and 30 days after exposure. Binding capacity of 125-1 labeled triiodothyronin by lymphocyte receptors was found to change depending on the dose of external irradiation and time elapsed since the exposure. The most marked and earliest changes in the parameters of hormonal-receptor interaction were observed after irradiation in dose 1 Gy.
Philosophy for Children: Some Assumptions and Implications
Authors: Lipman Matthew
Published: November 2019

It is a pleasure to be able to thank the editors of Ethik und Sozialwissenschaften for inviting me to write this paper about the Philosophy for Children program, with which I have been associated since it began at the end of the 1960's
A Research in China Based on the Moral Judgement Test
Authors: Yang Shaogang , Wu Huihong
Published: November 2019

In this research we use “the Moral Judgment Test” as an instrument that is developed by Professor Georg Lind in 1976, but is a Chinese version with some revisions, with 724 students whose ages are from 14 years old to 27 years old as the participants. The results show that: the C-scores are increased with the increase of the students’ age, but there are some fluctuations among different grades. It is obvious that the school education do could improve students’ abilities of moral judgment, but there exist some instability factors. There are no significant differences in their C-scores between male and female students, among different grades within certain schools and universities, and among students with various professions, the key schools and the regular schools as well as the two-year and the four-year college students.
Misrecognized Violence against Women and Perpetrated by Women. Seeking Remedies
Authors: Dutka Joanna
Published: November 2019

This paper explores the misrecognition of women's experience with violence in order to understand better what kinds of approaches to the problem would make it possible to design successful strategies for the prevention of violence. Violence itself, as well as common misconceptions regarding its mechanisms, carries ramifications that go far beyond direct and physical injury. The prevalence of violence and lack of social awareness regarding its mechanisms result in limitations to the social participation of many individuals and groups. Among the groups affected, women have an important place, both due to their number and the way that femininity relates to and disturbs other identities.
Influence of Rapid Transit on Accessibility Pattern and Economic Linkage at Urban Agglomeration Scale in China
Authors: Hong Wuyang , Su Mo
Published: November 2019

The development of high-speed railways has become an important factor influencing regional pattern changes in China. In this study, an accessibility evaluation model was constructed in combination with regional scale and regional center city to research the effect of high-speed rails on accessibility in the South Jiangsu, an urban agglomeration in China. Based on accessibility index, urban economic and social statistics data were used in conjunction with a gravity model to analyze the characteristics and evolvement of economic relations in this area. The result shows that high-speed rails improve overall regional accessibility, significantly benefit regions along rail lines, and makes middle- and long-distance journeys more convenient for the general public. High-speed rails play a particularly dominant role in the evolution of economic linkage and effectively strengthen the ties between cities. When the bonds between cities along rail lines greatly improve, a basic framework of economic relations is formed. Finally this paper discusses the imbalance arising from the effect of high-speed rails, proposing such suggestions as improving urban traffic and building expressways that connect high-speed rail stations in marginal areas to improve accessibility.
Near Infrared Spectroscopic Study of Trioctahedral Chlorites and Its Remote Sensing Application
Authors: Yang Min , Han Ling , Xu Youning , Ke Hailing , Zhou Ningchao , Dong Hui , Liu San , Qiao Gang
Published: November 2019

The mineral chemistry of thirteen trioctahedral chlorite samples from four regions in northwestern China, having a wide range of Fe and Mg contents and relatively constant Al and Si contents, were studied via raman spectroscopy, near infrared (NIR) spectroscopy, X-ray diffraction (XRD) analysis and electron - probe microanalysis. Five absorption features of the twenty samples near 4525, 4440, 4350, 4270 and 4180 cm−1 were observed, and two diagnostic features at 4440 and 4270 cm−1 were recognized. Assignments of the two diagnostic features were made for two combination bands ((ν+δ)(AlAl)O−OH and (ν+δ)(SiAl)O−OH) by regression with Raman fundamental absorptions. Furthermore, the determinant factors of the NIR band position were found by comparing the band positions with relative components. The results showed that Fe2+/(Fe2++Mg) values are negatively correlated with the two NIR combination bands. The findings provide an interpretation of the NIR band formation and demonstrate a simple way to use NIR spectroscopy to discriminate between chlorites with different components. More importantly, a simple example of mapping Fe-rich and Mg-rich chlorites were executed using remote sensing data based on this theory. The spectroscopic detection of mineral chemical variations in chlorites provides geologists with a tool with which to collect information on hydrothermal alteration zones from hyperspectral-resolution remote sensing data.
An apple a day …
Authors: Stifter David
Published: November 2019

This article presents hitherto overlooked evidence that suggests that the Old Irish word for the ‘apple’, ubull, was originally a neuter u-stem. This is then integrated into a general picture of the words for ‘apple’ in Celtic and Indo-European. Along the way, several other problems are discussed: it is demonstrated that the normal, if not regular, genitive plural of neuter u-stems in Old Irish had the ending -Ø; the rules for the operation of MacNeill’s Law after b /β/ are refined; and the question of the regular reflex of *su̯ in Old Irish is investigated.
On Indo-European superlative suffixes
Authors: Luján Eugenio R.
Published: November 2019

The goal of this paper is to provide some insights into the degree morphology of the ancient IE languages, specifically the superlative suffixes *‑is-toand *‑is- ̊mo-, which have a wider dialectal distribution and could go back to PIE. The relationship of those superlative suffixes to ordinal suffixes is known, but its nature has not been appropriately explained. The suffixes *‑to- and *‑mo- must have originated in the ordinals as thematic formations derived from cardinals and then expanded to the superlatives through the ordinal ‘first’ and other semantically related adjectives (‘last’ and polar/spatial adjectives). Those words provide the semantic and combinatory links between ordinals and superlatives that account for the shared morphology, as the textual evidence also proves. The use of *‑to- and *‑mo- in all those words across the Indo-European languages shows a systematic correlation. The suffixes *‑is-to- and *‑is- ̊mo- are a nice example of transparent nesting, since both include the zero-grade of the comparative suffix. They must have started as relative superlatives, given that ‘first’, ‘last’ and the other related words cannot be absolute superlatives. This is in accordance with a general tendency of evolution of the expressions of the superlative degree.
The Effect of Heating Temperature on Total Phenolic Content, Antioxidant Activity, and Phenolic Compounds of Plum and Mahaleb Fruits
Authors: Ghafoor Kashif , Ahmed Isam A. Mohamed , Doğu Süleyman , Uslu Nurhan , Fadimu Gbemisola J. , Al Juhaimi Fahad , Babiker Elfadıl E , Özcan Mehmet Musa
Published: November 2019

The effect of heating at different temperatures (60, 80, 90, 110, and 130 °C) on the total phenolic content, antioxidant activity, and phenolic compounds present in plum and mahaleb fruits was investigated. The antioxidant activity values and total phenolic contents of fresh plum (93.82% measured by DPPH method, 787.79 mg gallic acid equivalent (GAE)/100 g dry weight determined by Folin method) and mahaleb fruits (81.80%, 634.47 mg GAE/100 g dry weight) were higher than plum and mahaleb fruits dried at different temperatures (p < 0.05). Generally, the heating process caused a reduction in both total phenolic content and antioxidant activity for plum and mahaleb. While (+)-catechin (92.62 mg/kg), 1,2-dihydroxybenzene (132.15 mg/kg), gallic acid (107.01 mg/kg), and 3,4-dihydroxybenzoic acid (74.59 mg/kg) are the key phenolic compounds in fresh plum, (+)-catechin, 3,4-dihydroxybenzoic acid, 1,2-dihydroxybenzene, and syringic and caffeic acids were the major phenolic compounds of mahaleb fruits. The polyphenol content of fruits and the class of phenolics present are significantly affected by heating temperature.
Approaches to Play Directing in Contemporary Nigerian Theatre: A Study of Segun Adefila and Bolanle Austen-Peters
Authors: Mark Gasper Tekena
Published: November 2019

Documentation remains one of the major challenges of the Nigerian theatre; as a result many theatrical performances have gone into oblivion. Studies have been conducted that have given birth to the many approaches to play production and theories of directing in the Nigerian theatre. However, most of these studies focused on directors in educational theatres, as many directors outside the academia seem not to have attracted much scholarly interest in terms of documentation. This research documents the directorial approaches of two Nigerian directors – Segun Adefila and Bolanle Austen-Peters – using four productions and will be of benefit to theatre scholarship and the industry. The study employs a qualitative method of research, and the findings reveal Segun Adefila as an anti-realistic director and Bolanle Austen-Peters as a realistic director. Also, both directors use film to support live drama in their productions. This study therefore recommends that directors embrace the use of film in live theatre, in line with technological trends around the world.
Death and contact-induced rebirth of impersonal pronouns. A case study
Authors: D'Alessandro Roberta
Published: November 2019

Abruzzese, a southern Italian variety spoken in the central Italian region of Abruzzo, makes use of an impersonal pronoun, nomə, which is the continuation of Latin hŏmo (D'Alessandro & Alexiadou 2006). Nomə is used both as an arbitrary 3rd person pronoun and as a generic pronoun. Its use was quite widespread in the Abruzzo and Molise regions until about 50 years ago; however, as a result of heavy contact with Italian, it has recently been almost completely abandoned, and appears to be used only by the older generation of speakers. Its function has also been reshaped, in that it mostly serves as a marker of plurality on verbs.

The loss of impersonal pronouns is a common trend in the European area, as witnessed by the typological study conducted by Giacalone Ramat & Sansò (2007). This typological trend, particularly combined with the significant decay of the dialects in favor of a generalized use of regional Italian, means that the creation of new impersonal pronouns is wholly unexpected. However, it appears that a new impersonal pronoun, annə, is in fact emerging in Abruzzese, and is almost entirely replacing nomə in most areas of Eastern Abruzzo. The development of this impersonal pronoun is following a rather unusual path, seeming to be the result of the re-adaptation of an auxiliary borrowed from Italian.

This paper examines the diachronic development of both pronouns, showing that they follow opposite paths. While nomə is grammaticalizing into a plural marker, annə is degrammaticalizing into an arbitrary pronoun.
Influence of Gait Retraining on Running Economy: A Review and Potential Applications
Authors: Moran Matthew F. , Wager Justin C.
Published: November 2019

Running gait retraining has been reported to reduce lower-extremity loads and the risk for some running-related injuries. This has provided evidence that distance running gait can safely be modified in runners. Optimal running gait at a given speed is the product of anthropometric, neuromuscular, fatigue, and external factors. Because running biomechanics are integrally linked with economy, a major determinant of endurance running performance, it is conceivable that gait retraining could improve performance. The evidence investigating the influence of gait retraining on running economy will be evaluated and potential applications discussed.
Experimental Determination of Limits of Detection for Volatile Organic Compounds in Ambient Air Measured by Automatic Gas Chromatograph and Comparison with Reference Methods
Authors: Gutiérrez-Sama Sara , Bazin Damien , Robert Michel , Amiet Franck
Published: November 2019

Automatic gas chromatograph (auto-GCs) manufacturers perform an experimental method for a simple, rapid, and low-cost detection limit evaluation for volatile organic compounds in ambient air. The principle is the estimation of a minimum area of a peak. It is a relevant area value that discerns a real peak from the ground noise. This experimental limit of detection is equal to the minimum area unit multiplied by a known ratio concentration or area unit defined after calibration. Three different international methods have been compared with this experimental method: the calibration curve method issued in Europe for Monitoring Certification Scheme, the method detection limit issued during a gas chromatograph evaluation study organized by the U.S. Environmental Protection Agency, and a third international method based on an approach by the use of background noise. The exploitation of the different results concludes that this experimental method gives values in the same order of magnitude as the other methods. This experimental approach is concrete and beneficial for the improvement of auto-GCs: less ground noise, more sample volume trapped, and increase in the value area unit or mass injected.