bluuebunny/crossref_metadata_2025 huggingface dataset:
In Silico Studies on Anti-Stress Compounds of Ethanolic Root Extract of Hemidesmus indicus L.
Authors: Daddam Jayasimha R. , Sreenivasulu Basha , Umamahesh Katike , Peddanna Kotha , Rao Dowlathabad M.
Published: December 2019

Background:

Alternative medicine is available for those diseases which cannot be treated by conventional medicine. Ayurveda and herbal medicines are important alternative methods in which the treatment is done with extracts of different medicinal plants. This work is concerned with the evaluation of anti-stress bioactive compounds from the ethanolic root extract of Hemidesmus indicus.

Methods:

Gas chromatography and Mass Spectrum studies are used to identify the compounds present in the ethanolic extract based on the retention time, area. In order to perform docking studies, Vasopressin model is generated using modeling by Modeller 9v7. Vasopressin structure is developed based on the crystal structure of neurophysin-oxytocin from Bos taurus (PDB ID: 1NPO_A) collected from the PDB data bank. Using molecular dynamics simulation methods, the final predicted structure is obtained and further analyzed by verifying 3D and PROCHECK programs, confirmed that the final model is reliable. The identified compounds are docked to vasopressin for the prediction of anti-stress activity using GOLD 3.0.1 software.

Results:

The predicted model of Vasopressin structure is stabilized and confirmed that it is a reliable structure for docking studies. The results indicated ARG4, THR7, ASP9, ASP26, ALA32, ALA 80 in Vasopressin are important determinant residues in binding as they have strong hydrogen bonding with phytocompounds. Among the 21 phytocompounds identified and docked, molecule Deoxiinositol, pentakis- O-(trimethylsilyl) showed the best docking results with Vasopressin.

Conclusion:

The identified compounds were used for anti-stress activity by insilico method with Vasopressin which plays an important role in causing stress and hence selected for inhibitory studies with phytocompounds. The phytocompounds are inhibiting vasopressin through hydrogen bodings and are important in protein-ligand interactions. Docking results showed that out of twenty-one compounds, Deoxiinositol, pentakis-O-(trimethylsilyl) showed best docking energy to the Vasopressin.
Cancer Cell-derived Secretory Factors in Breast Cancer-associated Lung Metastasis: Their Mechanism and Future Prospects
Authors: Urooj Tabinda , Wasim Bushra , Mushtaq Shamim , Shah Syed Nudrat Nawaid , Shah Muzna
Published: December 2019

:

In Breast cancer, Lung is the second most common site of metastasis after the bone. Various
factors are responsible for Lung metastasis occurring secondary to Breast cancer. Cancer cellderived
secretory factors are commonly known as ‘Cancer Secretomes’. They exhibit a prompt role
in the mechanism of Breast cancer lung metastasis. They are also major constituents of hostassociated
tumor microenvironment. Through cross-talk between cancer cells and the extracellular
matrix components, cancer cell-derived extracellular matrix components (CCECs) such as
hyaluronan, collagens, laminin and fibronectin cause ECM remodeling at the primary site (breast) of
cancer. However, at the secondary site (lung), tenascin C, periostin and lysyl oxidase, along with
pro-metastatic molecules Coco and GALNT14, contribute to the formation of pre-metastatic niche
(PMN) by promoting ECM remodeling and lung metastatic cells colonization. Cancer cell-derived
secretory factors by inducing cancer cell proliferation at the primary site, their invasion through the
tissues and vessels and early colonization of metastatic cells in the PMN, potentiate the mechanism
of Lung metastasis in Breast cancer.

:

On the basis of biochemical structure, these secretory factors are broadly classified into proteins and
non-proteins. This is the first review that has highlighted the role of cancer cell-derived secretory
factors in Breast cancer Lung metastasis (BCLM). It also enumerates various researches that have
been conducted to date in breast cancer cell lines and animal models that depict the prompt role of
various types of cancer cell-derived secretory factors involved in the process of Breast cancer lung
metastasis. In the future, by therapeutically targeting these cancer driven molecules, this specific
type of organ-tropic metastasis in breast cancer can be successfully treated.
The Modulation of Pain by Metabotropic Glutamate Receptors 7 and 8 in the Dorsal Striatum
Authors: Boccella Serena , Marabese Ida , Guida Francesca , Luongo Livio , Maione Sabatino , Palazzo Enza
Published: December 2019

The dorsal striatum, apart from controlling voluntary movement, displays a recently demonstrated pain inhibition. It is connected to the descending pain modulatory system and in particular to the rostral ventromedial medulla through the medullary dorsal reticular nucleus. Diseases of the basal ganglia, such as Parkinson's disease, in addition to being characterized by motor disorders, are associated with pain and hyperactivation of the excitatory transmission. A way to counteract glutamatergic hyperactivation is through the activation of group III metabotropic glutamate receptors (mGluRs), which are located on presynaptic terminals inhibiting neurotransmitter release. So far the mGluRs of group III have been the least investigated, owing to a lack of selective tools. More recently, selective ligands for each mGluR of group III, in particular positive and negative allosteric modulators, have been developed and the role of each subtype is starting to emerge. The neuroprotective potential of group III mGluRs in pathological conditions, such as those characterized by elevate glutamate, has been recently shown. In the dorsal striatum, mGluR7 and mGluR8 are located at glutamatergic corticostriatal terminals and their stimulation inhibits pain in pathological conditions such as neuropathic pain. The two receptors in the dorsal striatum have instead a different role in pain control in normal conditions. This review will discuss recent results focusing on the contribution of mGluR7 and mGluR8 in the dorsal striatal control of pain. The role of mGluR4, whose antiparkinsonian activity is widely reported, will also be addressed.
Recent Advances and Future Perspectives in Pharmaceutical Analysis
Authors: Bakirhan Nurgul K. , Ozkan Sibel A.
Published: December 2019

The role of the analytical methods and their validations has been important in quantification of drugs from their
dosage forms or biological samples in recent years. Development of analytical methodscoupled with each other, is useful
for the investigation of behavior of drugs or metabolites or impurities, and is also a useful tool for sensitive detections.
The recent roles of spectroscopy, chromatography, titrimetry, electrochemistry and capillary electrophoresis have been
explained here.
Lentiviral-Mediated Beclin-1 Overexpression Inhibits Cell Proliferation and Induces Autophagy of Human Esophageal Carcinoma Eca109 Cell Xenograft in Nude Mice
Authors: Zhang Junhe , Dong Weihua
Published: December 2019

Background:

Esophageal carcinoma is one of the common malignant tumors in digestive
tract. BECLIN-1 is a key gene that regulates autophagy, and its abnormal expression may be related
with many human tumors. However, the mechanism of BECLIN-1 in esophageal carcinoma remains
unknown.

Objective:

In this study, we explored the effect of BECLIN-1 overexpression on tumor growth in mice
with esophageal carcinoma and its mechanism.

Methods:

Recombined lentiviral vector containing BECLIN-1 was used to transfect human esophageal
carcinoma Eca109 cells and establish stable cell line. qRT-PCR was used to detect BECLIN-1 mRNA
level in the transfected Eca109 cells, CCK-8 assay was used to detect cell proliferation. Beclin-1, P62
and LC3-II protein expression levels in Eca109 cells were detected using Western blot analysis. Subcutaneous
xenograft nude mice model of human esophageal carcinoma was established, and the tumor
growths in Beclin-1 group, control group and empty vector group were monitored. Beclin-1 protein
expression in vivo was detected by immunohistochemistry.

Results:

Beclin-1 mRNA and protein were overexpressed in Eca109 cells. Compared with empty vector
group, the growth rate of cells transfected with BECLIN-1 decreased significantly. Compared with
the control group and empty vector group, the expression level of P62 protein in beclin-1 group was
significantly decreased, while the expression level of LC3-II protein was significantly increased. The
tumor growth rate in nude mice of Beclin-1 group was significantly lower than that of the control
group and empty vector group, and Beclin-1 protein was mainly expressed in Beclin-1 group in vivo.

Conclusion:

BECLIN-1 can induce autophagy in esophageal carcinoma Eca109 cells, and it can significantly
inhibit the growth of esophageal carcinoma.
Cisplatin and Probiotic Biomass Loaded Pessaries for the Management of Cervical Cancer
Authors: Negi Deepa , Singh Amandeep , Joshi Navin , Mishra Neeraj
Published: December 2019

Introduction:

Cancer is a type of disease, in which the growth of cells is abnormal and uncontrolled.
One of the most common cancers among women is cervical cancer. In India, cervical cancer is one of leading
causes of cancer mortality among women 30 to 69 years of age, accounting for 17% of all cancer deaths. The
work present here shows the combined effects of anticancer drug along with probiotics to circumvent the side
effects associated with chemotherapy and to enhance the therapeutic effect.

Material and Methods:

Cisplatin and drug loaded pessaries were prepared by melt mold method using the
blend of PEG’s (Polyethylene Glycol) and further characterized for various in vitro and in vivo parameters.

Result and Discussion:

The free radical scavenging activity of probiotic Lactobacillus rhamnosus by DPPH
(2,2-diphenyl-1-picrylhydrazyl) assay was observed to be 60.77μg/mL The mean weight variation, melting time,
content uniformity, friability and hardness of the prepared pessary were 1.25±0.025mg, 10.86±0.64min,
99.89±0.74, 0.25%, 2.2kg/cm2. Histopathology studies presented that the developed formulation are safe for
local delivery of cisplatin.

Conclusion:

This study provides the basis for a combination of local delivery approach along with the beneficial
effects of probiotic strain which could be better a approach for the treatment of cervical cancer.
Isolated Linear Discoid Lupus Erythematosus of Scalp Following Lines of Blaschko
Authors: Almurayshid Abdurrahman , Al Obaid Sulaiman
Published: December 2019

Discoid lupus erythematosus (DLE) is an inflammatory autoimmune disease leading to scarring and hair loss. Linear Discoid lupus erythematosus has been mentioned in the literature as a rare variant. This article describes isolated linear DLE of the scalp. We present a 26-year-old Saudi male who had unilateral linear DLE of the scalp with no involvement of other body sites and no systemic manifestations. This case is the first case of isolated linear DLE on the scalp. This presentation should be considered as a differential diagnosis of linear scarring alopecia as a distinct morphological pattern of DLE.
Photonic Crystal Based Bio-Sensor Detection in Nanophotonic Structure Using FEM Method
Authors: Ghoumazi Mehdi , Hocini Abdesselam
Published: December 2019

Background & Objective:

In this article, a nano-cell coupled 2D photonic crystal
waveguide bio- detection platform is proposed for the detection of organic liquids such as water,
ethanol, glycerol, benzene and bromine for different refractive indices (n).

Methods:

The detection characteristics are analyzed and obtained for the band diagram, before and
after change of radius (r) as well as after the injection of liquids into the heart of the nanostructure
cell at the resonant wavelength (λ res). Also, we extracted variations from the power flow norm (P)
to the resonance and the transmission (T) for each material. This nanostructure for different (n) materials
used, gives (P) at different levels to the resonance. This explains the importance of the refractive
index parameter (n) which plays a crucial role in the detection of materials.

Results & Conclusion:

The proposed biosensor enables the detection of liquids. This is shown
through the numerical results obtained. These results give a good observation of the different behavior
of the signal in the presence of the liquids used which depend on their refractive indices 'n'. This
parameter 'n' is very important for detection when it varies from material to material. The proposed
biosensor can be used in several research areas, particularly in medical and environmental applications.
Intuitionistic Fuzzy Score Function Based Multi-Criteria Decision Making Method for Selection of Cloud Service Provider
Authors: Agrawal Sonal , Tripathi Pradeep
Published: December 2019

Aims & Background:

Cloud Computing (CC) has received great attention from the
scholarly researchers and IT companies. CC is a standard that offers services through the Internet.
The standard has been manipulated by existing skills (such as collect, peer-to-peer and grid computing)
and currently accepted by approximately all major associations. Various associations like
as Microsoft and Facebook have revealed momentous investments in CC and currently offer services
with top levels of reliability. The well-organized and precise evaluation of cloud-based
communication network is an essential step in assurance both the business constancy and the continuous
open services.

Objectives & Methods:

To select and rank the CC service providers, we introduce an Improved
Score Function (ISF) based Multi-Criteria Decision-Making (MCDM) approach. The proposed
approach is developed to solve the MCDM problems with partly unknown weight. To do this, the
criteria preferences are given in terms of Intuitionistic Fuzzy Sets (IFSs). Numerical example is
illustrated to show the effectiveness of the proposed approach over the previous ones.

Results:

A decision making problem of cloud computing service provider has been considered for
signifying the developed technique and finishes with the outcomes coincide with the already developed
methods which confirms the solidity of the developed method.

Conclusion:

For future, we plan to implement the proposed technique on various decision making
problems, clustering and multi-objective problems. Also, we plan to extend our method under different
uncertain atmosphere by using other MCDM methods.
Isolated Word-Based Spoken Dialogue System Using Odia Phones
Authors: Swain Basanta K. , Mohanty Sanghamitra , Chowdhary Chiranji L.
Published: December 2019

Aims:

To develop Spoken Dialogue System in Indian language with Voice response and
voice based biometric feature.

Backgrounds:

Most of research works in spoken dialogue system are carried out in U.S. and Europe
and currently, few government funding projects on spoken dialogue system (SDS)
are carried out in Indian academic institutes.

Objective:

We have tried to use our developed spoken language system to eliminate the desktop
clutter. It is very normal tendency of computer users to place the most frequently used files, folders,
applications shortcuts on their computer’s desktop. Cluttering of desktop not only slows down
the productivity of computer but also looks very messy and very difficult to find files as well.
Therefore, we tried to use the spoken dialogue system to eliminate the desktop clutters in painless
manner and the services are provided to the computer users by opening the files, folders and frequently
used application of users in spoken command mode with voice response.

Methods:

In this research article, we have attempted to utilize an Indian spoken language for
communication with spoken dialogue system. We have adopted a statistical machine learning algorithm
called Hidden Markov Model for development of speech recognition engine. The speaker
verification module is developed using fuzzy c-means algorithm. Speech synthesis is carried out
using diphone corpus.

Results:

The speaker verification module has yielded satisfactory results with average accuracy of
66.2% using FCM algorithm. It is also seen that fundamental frequency and formant frequency carry
the distinctive characteristics of speaker verification over Indian spoken language. The vital
module of SDS i.e. speech recognition engine is developed by using HMM, a statistical algorithm.
It is observed that word accuracy of ASR engine is 78.22 % and 62.31 % for seen and unseen users
respectively. The voice response is given to the user in terms of synthesized speech. The audio
quality of synthesized speech is measured using the MOS test. The MOS test value is found as 3.8
and 3.6 over two distinct groups of listeners.

Conclusion:

In this research paper, we have developed a spoken dialogue system based on Odia
language phone set. We have integrated speaker verification module in order to provide additional
biometric based security.
Improving Data-Throughput in Energy Harvesting Wireless Sensor Networks Using a Data Mule
Authors: Kumar Naween , Dash Dinesh
Published: December 2019

Background:

In Energy Harvesting Wireless Sensor Networks (EH-WSNs), sensors are
harvesting energy from the renewable environment to make their operations endless and uninterrupted.
However, in such a network, the time-varying nature of harvesting imposes a challenging
issue in obtaining improved data-throughput. The use of a static-sink in EH-WSNs to improve data-
throughput is less reliable because there is no assurance of the network connectivity. To alleviate
such shortcomings, a Data Mule (MDM) has been introduced in EH-WSN for collecting sensors’
data. In this article, the MDM-based distance constrained tour finding problem is formulated
such that the data-throughput can be improved within a given delay constraint.

Methods:

To solve the problem, we devise two different heuristic algorithms based on two different
metrics.

Results:

The obtained experimental results demonstrate that the devised algorithms are more effective
than the existing algorithms in terms of data-throughput.

Conclusion:

The data-throughput values of the first proposed algorithm are about 6.14% and
3.56% better than the other for two different data gathering time durations of 100 sec and 800 sec.
The data-throughput values of the second proposed algorithm are about 5.03% and 5.25% better
than the other for two different data gathering time durations of 100 sec and 800 sec.
Allometric equations for total aboveground dry biomass and carbon content of Pinus occidentalis trees
Authors: Bueno-López Santiago Wigberto , García-Lucas Encarnación , Caraballo-Rojas Luis Rene
Published: December 2019

Although precise species-specific aboveground tree biomass equations are needed in the Dominican Republic to quantify potential carbon storage in the context of climate change and sustainable forest management, there has been a lack of available information concerning total aboveground biomass and/or carbon content for naturally occurring Pinus occidentalis trees. The objectives of the study were to develop species-specific allometric biomass models for P. occidentalis, as well as to assess variation in carbon concentration among stem plus bark, branches and foliage by means of chemical analyses. Predictor variables included diameter at breast height (DBH) and total tree height (H), alone and in combination. Model fitting methods employing linear and nonlinear regression techniques were used and evaluated based on goodness-of-fit criteria. Two competing biomass models produced similar goodness-of-fit statistics: model 4, fitted by the Weighted Non-linear Least Squares technique, , and model 6, fitted by modeling the variance component and applying the Maximum Likelihood method, . Average carbon concentration (%) was highest in foliage tissue (49.8%), followed by branches (46.37%) and, lastly, stem plus bark (45.95%). On average, each individual tree is storing 175 kg of total aboveground carbon. To our knowledge, this is the first account reporting carbon fraction for this tropical species. Calculated wood carbon fractions from the study can be easily incorporated into forest C accounting, and may reduce errors in forest C valuations, which nowadays are performed using global estimates published elsewhere.
Применение высокочастотной ЭПР спектроскопии для идентификации и разделения позиций азота и ванадия в кристаллах и гетероструктурах карбида кремния
Authors: Единач Е.В. , Криворучко А.Д. , Гурин А.С. , Музафарова М.В. , Ильин И.В. , Бабунц Р.А. , Романов Н.Г. , Бадалян А.Г. , Баранов П.Г.
Published: December 2019

Abstract The advantage of the high-frequency spectroscopy of electron paramagnetic resonance (EPR) for the identification of nitrogen donors and a deep compensating vanadium impurity in various crystallographic positions of the silicon-carbide crystal is shown. Measurements are performed using a new generation EPR spectrometer operating in the continuous wave and pulsed modes at frequencies of 94 and 130 GHz in a wide range of magnetic fields (–7–7 T) and temperatures (1.5–300 K). A magneto-optical closed-cycle cryogenic system (Spectormag PT), highly stable generators (94 and 130 GHz), and a cavity-free system for supplying microwave power to the sample are used.
Приближенный метод описания эволюции, предшествующей коалесценции
Authors: Курасов В.Б.
Published: December 2019

A new approximate method to describe the evolution of the system at the period after the end of essential consumption of a metastable phase and before the coalescence is proposed. The properties of evolution during this period are analyzed and it is shown why the Lifshic-Slesov asymptote is attained so quickly.
Вертикальное смещение магнитооптической петли гистерезиса в магнитоплазмонном нанокомпозите
Authors: Томилин С.В. , Бержанский В.Н. , Шапошников А.Н. , Прокопов А.Р. , Каравайников А.В. , Милюкова Е.Т. , Михайлова Т.В. , Томилина О.А.
Published: December 2019

In article the synthesis and investigation results of magneto-optical (MO) properties of thin-film nanocomposite, which is a bismuth-substituted Bi: YIG ferrite garnet layer with Au plasmon nanoparticles are representative. The effect of vertical shift of MO hysteresis loops (relative to the origin of coordinates) was detected with study of MO properties during remagnetization of the magnetoplasmon composite structure. It’s shown that the observed effect is most pronounced near the condition of localized plasmon resonance in the metal nanoparticles system which make up the magnetoplasmonic composite.
Экспериментальные и теоретические исследования эффективности автономных компактных многоэтажных ветроэлектростанций
Authors: Кунакбаев Т. , Танашева Н.К. , Дюсембаева А.Н. , Шаймерденова К.М. , Сагитжанов Б.М.
Published: December 2019

A study of compact multi-story wind farms created by the authors for the first time in the world. Their effectiveness due to autonomy, compactness and use of the phenomenon is shown, drafts arising between floors. Due to this, compact multi-story wind farms will have certain advantages over conventional wind farms and individual wind generators of the same power
Колебательно-вращательный анализ "горячей" полосы 2ν_2-ν-=SUB=-2-=/SUB=- молекул -=SUP=-15-=/SUP=-NH-=SUB=-2-=/SUB=-D и -=SUP=-15-=/SUP=-NHD-=SUB=-2-=/SUB=-
Authors: Фомченко А.Л. , Белова А.С. , Кузнецов А.В.
Published: December 2019

The high-resolution spectra of the “hot” 2ν2-ν2 band of the 15NH2D and 15NHD2 molecules were studied for the first time. The analysis is based on the ground state combination differences method. As a result, the energy structure of the inversion-vibrational state (v2 = 2, s) was obtained for both studied molecules; more than 480 vibrational-rotational transitions of the “hot” bands were assign. The values ​​of the upper energy levels determined on the basis of the line positions were used as initial data to determine the spectroscopic parameters of the state (v2 = 2, s).
Спектрально-люминесцентные и генерационные свойства растворов мероцианинового красителя в присутствии наночастиц серебра
Authors: Афанасьев Д.А. , Ибраев Н.Х. , Омарова Г.С. , Кулинич А.В. , Ищенко А.А.
Published: December 2019

Исследовано влияние наночастиц (НЧ) серебра на спектрально-люминесцентные и генерационные свойства положительно сольватохромного мероцианинового красителя в этанольном растворе. Обнаружен рост сечения поглощения, интенсивности и длительности флуоресценции красителя при добавлении в раствор НЧ. Это обусловливает снижение порога генерации мероцианина. В результате в присутствии НЧ серебра (CAg=10-12 mol/L) ее удалось получить при той же концентрации (10-4 mol/L) красителя, при которой она не была достигнута в их отсутствие. Показательно, что плотность мощности лазерной накачки в первом случае была меньше, чем в последнем. Ключевые слова: мероцианиновый краситель, наночастицы серебра, плазмонный эффект, интенсивность поглощения и флуоресценции, вынужденное излучение.
К теории рассеяния Мандельштама-Бриллюэна в плазменном слое
Authors: Двинин С.А. , Солихов Д.К. , Нурулхаков Ш.С.
Published: December 2019

The evolution of a perturbation from a local source for Mandel'shtam-Brillouin scattering in a plasma layer with unlimited length is calculated. Perturbation over time in this case can either leave the scattering region through one of the two boundaries, or propagate along the layer at a speed below sound wave propagation speed, with an exponential growth, or a fall in perturbation amplitude. In the particular case of strictly backward scattering (the scattering angle is π), this propagation velocity is zero. The paper calculates the threshold instability fields and the instability increments, taking into account both convective losses and collisional attenuation of waves. It is shown that the instability threshold for scattering at an arbitrary angle can be lower than for strictly backwards scattering and when the threshold is exceeded by the intensity of the pump wave; the scattering increment at an angle can also be higher than the increment for backscattering. When the threshold is greatly exceeded, the convective losses can be neglected, and the largest increment is observed for backward scattering.
Изменение морфологии, структуры и микротвердости образцов циркониевого сплава в результате воздействия лазерными импульсами
Authors: Проскуряков В.И. , Родионов И.В. , Кошуро В.А. , Куц Л.Е. , Перинская И.В.
Published: December 2019

The results of experimental studies on the modification of the surface layer of zirconium alloy grade E 110 by the action of pulsed laser radiation are presented. It was established that, as a result of laser treatment, the morphology of the surface layer changes with the formation of nanoparticles up to 50 nm in size. The relief of the treated surface becomes structurally heterogeneous, containing phases of zirconium and monoclinic ZrO2 dioxide. It was revealed that, as a result of exposure to laser pulses, a significant increase in the microhardness of the surface of zirconium samples occurs to 27.1 ± 0.1 GPa.
Применение полимерных пленок с наночастицами серебра для улучшения спектральных характеристик фотоэлектрических преобразователей
Authors: Лунин Л.С. , Девицкий О.В. , Кравцов А.А. , Пащенко A.С.
Published: December 2019

A method of the production of polyvinyl butyral films with silver nanoparticles was developed. Properties of the resulting films as anti-reflecting coatings for silicon photovoltaic converters (photoconverters) were studied. The experiments were carried out on samples with and without Si3N4 coating. It was indicated that, at maximum concentration of silver nanoparticles (7 mmol/l), the increase in the external quantum efficiency in the spectral range from 500 to 1000 nm was more than 20 % for the samples without Si3N4 coating. In the case of the engineered functional coatings onto the photoconverters with Si3N4, the quantum efficiency increased on average by 10 % in the range from 400 to 1000 nm, and by 15–20 % in the range from 320 to 400 nm.
Kazania adwentowe
Authors: Ostafiński Witold , Panuś Kazimierz
Published: December 2019

Niniejszy tom zawiera polskie kazania adwentowe od średniowiecza do początków XXI stulecia we współczesnej transkrypcji, opatrzone niezbędnym komentarzem. Mimo znacznego zróżnicowania sprawności językowej autorów, poziomu ich wykształcenia, konfesji oraz stosowanych przez nich środków wyrazu i siły przytaczanych argumentów wspólnym ich dążeniem było pragnienie przygotowania słuchaczy na przyjście Pana: zarówno w dniu Jego narodzin, pamiątkę czego celebruje się co roku 25 grudnia, jak i podczas paruzji, gdy – jak wyznajemy w Credo – „przyjdzie sądzić żywych i umarłych”, oraz to pomiędzy nimi, gdy rodzi się w człowieku przez życie sakramentalne. O ile dawniej kaznodzieje silnie podkreślali pokutny charakter adwentu, o tyle dzisiaj bardziej zwracają uwagę na fakt, iż jest to czas pobożnego i radosnego oczekiwania, także na drugie przyjście Chrystusa.
Accuracy of Machine Learning Algorithms for the Diagnosis of Autism Spectrum Disorder: Systematic Review and Meta-Analysis of Brain Magnetic Resonance Imaging Studies
Authors: Moon Sun Jae , Hwang Jinseub , Kana Rajesh , Torous John , Kim Jung Won
Published: December 2019

Background

In the recent years, machine learning algorithms have been more widely and increasingly applied in biomedical fields. In particular, their application has been drawing more attention in the field of psychiatry, for instance, as diagnostic tests/tools for autism spectrum disorder (ASD). However, given their complexity and potential clinical implications, there is an ongoing need for further research on their accuracy.

Objective

This study aimed to perform a systematic review and meta-analysis to summarize the available evidence for the accuracy of machine learning algorithms in diagnosing ASD.

Methods

The following databases were searched on November 28, 2018: MEDLINE, EMBASE, CINAHL Complete (with Open Dissertations), PsycINFO, and Institute of Electrical and Electronics Engineers Xplore Digital Library. Studies that used a machine learning algorithm partially or fully for distinguishing individuals with ASD from control subjects and provided accuracy measures were included in our analysis. The bivariate random effects model was applied to the pooled data in a meta-analysis. A subgroup analysis was used to investigate and resolve the source of heterogeneity between studies. True-positive, false-positive, false-negative, and true-negative values from individual studies were used to calculate the pooled sensitivity and specificity values, draw Summary Receiver Operating Characteristics curves, and obtain the area under the curve (AUC) and partial AUC (pAUC).

Results

A total of 43 studies were included for the final analysis, of which a meta-analysis was performed on 40 studies (53 samples with 12,128 participants). A structural magnetic resonance imaging (sMRI) subgroup meta-analysis (12 samples with 1776 participants) showed a sensitivity of 0.83 (95% CI 0.76-0.89), a specificity of 0.84 (95% CI 0.74-0.91), and AUC/pAUC of 0.90/0.83. A functional magnetic resonance imaging/deep neural network subgroup meta-analysis (5 samples with 1345 participants) showed a sensitivity of 0.69 (95% CI 0.62-0.75), specificity of 0.66 (95% CI 0.61-0.70), and AUC/pAUC of 0.71/0.67.

Conclusions

The accuracy of machine learning algorithms for diagnosis of ASD was considered acceptable by few accuracy measures only in cases of sMRI use; however, given the many limitations indicated in our study, further well-designed studies are warranted to extend the potential use of machine learning algorithms to clinical settings.

Trial Registration

PROSPERO CRD42018117779; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=117779
Influence of Cognitive Functioning on Powered Mobility Device Use: Protocol for a Systematic Review
Authors: Pellichero Alice , Kenyon Lisa K , Best Krista Lynn , Sorita Éric , Lamontagne Marie-Eve , Lavoie Marie Denise , Routhier François
Published: December 2019

Background

Power mobility devices (PMD) are critical to achieving independent mobility and social participation for many individuals who have trouble walking. Provision of PMDs is complex, with cognitive functioning expressed by clinicians as a major concern. Even if PMD use can be predicted by the level of cognitive functioning, outcome tools used to assess readiness do not consider how cognitive functioning may affect PMD use.

Objective

The specific aims of this review are to identify existing assessments used to assess cognitive functioning and PMD use, classify cognitive functions that are identified within existing assessments related to PMD use, and explore the relationships between cognitive functioning (ie, executive functions and attention) and PMD use.

Methods

A systematic review will be conducted using the electronic databases MEDLINE (Ovid), CINAHL, Embase, PsycINFO (Ovid), and Web of Science based on the concepts of PMD performance and capacity, and cognitive functioning. To be included, studies must have: a sample of PMD users (inclusive of age and diagnoses), an assessment of cognitive functioning, and an assessment of PMD capacity or performance. The International Classification of Functioning, Disability and Health will be used to classify cognitive functions. Study quality will be assessed using the Mixed Methods Appraisal Tool. Qualitative and quantitative studies will be analyzed in a complementary manner depending on their designs; a result-based convergent synthesis design will be applied.

Results

This proposed systematic review protocol has been registered in PROSPERO (CRD42019118957). It was funded by the Quebec Rehabilitation Research Network and approved on February 2019.

Conclusions

Results will inform the development of a PMD driving program that aims to enhance cognition. The results of this study will enhance understanding of the influence of cognitive functioning on PMD use and will support the clinical practice in choosing appropriate evaluative tools.

Trial Registration

PROSPERO CRD42019118957; https://www.crd.york.ac.uk/PROSPERO/display_record.php? RecordID=118957

International Registered Report Identifier (IRRID)

DERR1-10.2196/16534
Innovation in Pediatric Medical Devices: Proceedings From The West Coast Consortium for Technology & Innovation in Pediatrics 2019 Annual Stakeholder Summit (Preprint)
Authors: Espinoza Juan , Cooper Kathryne , Afari Nadine , Shah Payal , Batchu Sriharinarayana , Bar-Cohen Yaniv
Published: December 2019

UNSTRUCTURED

Pediatric medical devices cover a broad array of indications and risk profiles, and have helped to reduce disease burden and improve quality of life for numerous children. However, many of the devices used in pediatrics are not intended for or tested on children. Several barriers have been identified that pose difficulties in bringing pediatric medical devices to the market. These include a small market and small sample size; unique design considerations; regulatory complexities; lack of infrastructure for research, development, and evaluation; and low return on investment. In 2007, the Food and Drug Administration (FDA) created the Pediatric Device Consortia (PDC) Grants Program under the administration of the Office of Orphan Products Development. In 2018, the FDA awarded over US $30 million to five new PDCs. The West Coast Consortium for Technology & Innovation in Pediatrics (CTIP) is one of these PDCs and is centered at the Children’s Hospital Los Angeles. In February 2019, CTIP convened its primary stakeholders to discuss its priorities and activities for the new grant cycle. In this paper, we have presented a report of the summit proceedings to raise awareness and advocate for patients and pediatric medical device innovators as well as to inform the activities and priorities of other organizations and agencies engaged in pediatric medical device development.
Kertas Saring sebagai Media Transpor Darah untuk Pemeriksaan Antibodi Rabies
Authors: Wijayanti Retno , Damayanti Retno , Murtini Sri
Published: December 2019

Rabies is a zoonotic disease. Rabies protection level detection was performed using antibody titration. Blood sampling activities in the field require special handling to avoid blood lysis, the sample delivery requires a cold chain with a stable temperature. Alternative method forwhole blood sample delivery using filter paper were carried out on 48 samples from susceptible animals (dogs and cats) transpored through the Soekarno Hatta Agricultural Quarantine Center. This  study was designed to investigate the feasibility of filter paper sampling of blood at temperature of 26 °C to detect of rabies antibodies using indirect method of ELISA. The results of statistical analysis of  Randomized Block Design and Tukey's test showed that the antibody titres of whole blood extracted from filter paper diluted in the PBS T 100 μl were equivalent to antibody titres of serum. Assesment of filter paper capability has sensitivity and specificity as much as 96% and 76%, positive predictive value of 67%, negative predictive value of  94% and reliability level of filter paper were 0.5 is moderate category. This indicates that the filter paper can be used as an alternative method of blood transport medium for rabies ELISA test.
Validasi Metode Analisis Tetrasiklin pada Ikan Nila (Oreochromis sp.) menggunakan Alat Kromatografi Cair Kinerja Tinggi (KCKT)
Authors: Hakimah Nisa , Satria Gagak Donny , Pawestri Wari , Indarjulianto Soedarmanto
Published: December 2019

Antibiotics are substances that capable of inhibiting the growth of or killing microorganisms. The presence of residues in the tissues are associated with continuous use of antibiotics for long periods of time. The antibiotic residue that is often detected in freshwater fishery products is tetracycline. One method of analysis of tetracycline residues in fish meat is widely developed using high performance liquid chromatography (HPLC). This research was aimed to validate the method of analysis of tetracycline content in tilapia meat by using HPLC Shimadzu 6.1. The mobile phase consisting of methanol: acetonitrile: oxalic acid (5:15:80) with 1 ml / min flow rate, detector UV Vis with wavelength 355 nm, and C18Shim-pack column size 150 L x 4,6 mm at temperature of 30oC. The result of this research showed values corresponding to validation criteria based on parameters of specificity, precision, accuracy, linearity, limit of detection, and limit of quantification. Tetracycline analysis using HPLC tool has good and acurate validity as the first step in detecting the tetracycline level in tilapia meat.
Efektifitas Penambahan Insulin dalam Media Maturasi dan atau Media Kultur pada Tingkat Maturasi Oosit dan Perkembangan Awal Embrio Sapi secara In Vitro
Authors: Karja Ni Wayan Kurniani , Nanda Syafri , Setiadi Mohamad Agus
Published: December 2019

This study was aimed to determine the effect of insulin supplementation in maturation and/or culture medium on nuclear maturation rate and the early bovine embryo development in vitro. Oocytes were collected and matured in maturation media without (IVM I-) or with (IVM I+) 10 ug/µL insulin at incubator 5% CO2 and the temperature of 39 °C, for early embryonic development evaluation, oocytes were divided into 4 groups, without the supplementation of insulin to the maturation medium and culture (IVM I-/IVC I-), insulin supplementation only the maturation medium (IVM I+/IVC I-), insulin supplementation only in the culture medium (IVM I-/IVC I+), and the combination of insulin supplementation to the maturation medium and culture (IVM I+/IVC I+). The result showed that supplementation of insulin to the maturation medium increased number nuclear maturation was higher 87.7% (P<0.05) compared to treatment without supplementation of insulin (70.1%). Cleavage rate in treatment IVM was higher IVM I-/IVC I- (55.8%), IVM I+/IVC I- (64.1%), IVM I-/IVC I+ (59.9%) (P<0.05). Result of the other were showed that early bovine embryo on day-4 cultured (IVC) reached 16 cell on treatment IVM I-/IVC I+(31,9%) and IVM I+/IVC I+ (27,1%) were higher compared to treatment IVM I-/IVC I-(2.9%) and IVM I+/IVC I- (2.5%) (P<0.05). In conclusion, supplementation of insulin to maturation medium and culture medium can increase nuclear maturation rate and improved early embryo cleavage rate.
Studi In-Vivo Ekstrak Daun Teh Hijau (Camellia Sinensis) sebagai Alternatif anti Bakteri Eschericia Coli pada Ayam Broiler
Authors: Sutrisno Bambang , Wasito R. , Kurniasih Kurniasih , Widyarini Sitarina , Kristianingrum Yuli Purwandari , Sugiyono Sugiyono
Published: December 2019

The prevalence of colibasillosis  in chicken farms in Indonesia is very high, treatment using antibiotics is experiencing resistance, so it is necessary to look for alternatives to antibacterial. The study was aimed to determine the antibacterial effect of green tea leaf extract on broiler chickens infected with Eschericia coli by looking at the score of macroscopic lesions strengthened by histopathological examination, heterophile examination, plasma protein and fibrinogen. The research used 20 day old broilers (DOC) which were randomly divided into 4 groups, group A group B, group C and group D, each consisting of 5 DOC broilers. While maintaining ND and Gumboro vaccines on schedule like maintenance in general. At the age of 21 days all broilers in each group began to be treated as controls (Group A) without infecting E. coli and were not given 0,1g/ml  water extract of green tea leaves (Camillia sinensis). Group B, intratracheal-infected broilers with local strains of E.coli were 108 cells / ml according to 0,5  Mc Farland standard, and were not given green tea leaf extract. Group C, broilers infected by intratracheal with local strains of E. coli 108 cells / ml by 0,5 Mc Farland standard, and given to drink green tea leaf extract (Camillia sinensis) 0,1 g/ml and group D, broilers were given drinking green tea leaf extract (Camillia sinensis) 0,1g/ml. During the treatment all of chickens were given food and drink ad libitum. Fourteen days after infection of E.coli, 5 chickens in each group were collected to collect blood for heterophyll, total plasma protein (TPP) and fibrinogen. And then were euthanasied  with Mg SO4 saturated solution intravenously injection and necropsied  for gross and histpathological examination. Analysis of blood tests results were used one way of anova  (SPSS version 22 program), whereas for gross and histopathological examination with descriptive analysis. The results showed that the gross examination and histopathological organs of brolier infected with E. coli without being given a green tea extract experienced airsacculitis, pericarditis, perihepatitis and peritonitis, whereas broilers infected with E. coli and given green tea extract does not indicate the presence of inflammation. Examination of heterophile counts and blood fibrinogen levels had shown a difference (P <0.05), in broilers infected with E. coli and given green tea extracts had lower amounts of hetrophils and fibrinogen levels. While blood TPP levels were not significantly different (P> 0.05). The conclusion can be drawn, that the study of in vivo green tea extract (Camelia sinensis) 0,1g/ml has the potential to inhibit the infection of Eschericia coli bacteria in broiler chickens.
Aktivitas Ekstrak Daun Tithonia Diversifolia Terhadap Regulasi Kadar Adiponektin pada Diabetes Melitus Tikus Putih Wistar
Authors: Solfaine Rondius , Muniroh Lailatul , Mubarokah Wida Wahidah
Published: December 2019

Diabetes Melitus is a group of metabolic diseases characterized by hyperglycemia due to lack of insulin secretion or insulin activity resistance. Chronic hyperglycemia in diabetes is associated with long-term damage, dysfunction, and failure of various organs, especially the kidneys, kidneys, nerves, heart and blood vessels. The purpose of this study was to analyze the activity of Adiponektin, superoxide dismutase, malondialdehyde, and glucose level in Streptozotocin-induced diabetic wistar rats. All wistar rats were divided into 4 groups, control (D0), induction group (D1), thitonia extract dose 100 mg / kg bw (D2) and catechin dose 10 mg/kg bw (D3) for 7 days. Model diabetes were used by induction of streptozotocin (Stz) at dosage 60 mg / kg bw intraperitoneally (ip) for 7 days. On the 8th day after the treatment, all groups of rats were sacrificed for blood samples for measured levels of superoxide dismutase and malondialdehyde and Adiponektine protein using Elisa technique, and measure of glucose level with calorimetry technique. Statistical analysis of data to examine differences in treatment and control was conducted by one way Anova test with a 95% confidence level (α=0.05). The results showed that there were differences in glucose levels (p = 0.020) and Adiponektin (p = 0.001) between the control and treatment groups, but there were no differences in level of MDA (p = 0.103) and SOD (p = 0.207 ) between groups. Base on the results of the study concluded that the administration of Tithonia Diversifolia leaf extract could reduce blood sugar and Adiponectin concentrations significantly (p≤0.05) in streptozotocin-induced diabetic on rats.
La La franja fronteriza Chiapas-Guatemala. Notas de campo
Authors: Camacho velázquez Dolores
Published: December 2019

Se ofrece una narrativa sintética sobre avances de un proyecto de investigación que tiene como objetivo «Identificar, describir y reflexionar de manera colectiva sobre la complejidad que encierran las dinámicas sociales en la franja fronteriza Chiapas-Guatemala». Se adelantan resultados sobre los recorridos de campo efectuados y que tuvieron la pretensión de identificar algunos de los elementos que definen la vida en la frontera desde la perspectiva de quienes la habitan y, por supuesto, de sus interlocutores, en este caso un grupo de investigadores que llegamos a su territorio a preguntarles qué piensan sobre su vida en lo que llamamos la franja fronteriza de Chiapas-Guatemala. Se toma como contexto lo que se sabe de la frontera a través de libros y medios de comunicación, así como la discusión generada en los seminarios sobre el concepto de frontera
Umpolung in reactions catalyzed by thiamine pyrophosphate dependent enzymes
Authors: J. Boluda Carlos , Juncá Carolina , Soto Emily , De la Cruz Darah , Peña Anny
Published: December 2019

El intercambio temporal del carácter electrofílico/nucleofí-lico de un átomo mediante manipulación química, es cono-cido con el vocablo alemán de umpolung. Esta inversión de polaridad permite explorar nuevas posibilidades sintéticas que no pueden llevarse a cabo partiendo de la reactividad normal de los grupos funcionales. Se trata de una herra-mienta sintética útil, que también es utilizada por ciertas enzimas en determinadas reacciones bioquímicas que tienen lugar en las células. Las enzimas dependientes del pirofosfato de tiamina, como la piruvato descarboxilasa, la piruvato deshidrogenasa, la α-cetoglutarato deshidrogenasa, la deshidrogenasa de α-cetoácidos de cadena ramificada y la transcetolasa, proporcionan ejemplos claros de umpolungen reacciones celulares. En esta revisión, tras una discusión sobre el significado del término umpolung encontrado en la literatura química, se analizan los mecanismos de reacción y el significado bioquímico de las transformaciones llevadas a cabo por las enzimas mencionadas.
Emotive Figures as "Shown" Emotion in Italian Post-Unification Conduct Books (1860-1900)
Authors: Paternoster Annick
Published: December 2019

Within a digital corpus of 20 Italian post-unification conduct books (1860 to 1900), UAM CorpusTool is used to perform a manual annotation of 13 emotive rhetorical figures as indices of “shown” emotion (émotion montrée, Micheli 2014). The analysis consists in two text mining tasks: classification, which identifies emotive figures using the 13 categories, and clustering, which identifies groups, i.e. clusters where emotive figures co-occur. Emotive clusters mainly discuss diligence and parsimony—personal values linked to self-improvement for which reader agreement is not taken for granted. In this corpus they function as “moving” values, that is, values acting recurrently as contexts for “argued” emotion (émotion étayée, Micheli 2014).