bluuebunny/crossref_metadata_2025 huggingface dataset:
Renal post-mortem findings in myeloproliferative and myelodysplastic/myeloproliferative neoplasms
Authors: Person Fermin , Meyer Sara C. , Hopfer Helmut , Menter Thomas
Published: June 2021

Myeloproliferative neoplasms (MPN) are a heterogeneous group of hematological disorders presenting with an increased proliferation in one or several hematological cell lines. Renal manifestations of MPN have not been fully characterized so far. To morphologically assess the potential renal involvement in MPN patients, we analyzed histomorphological findings of a post-mortem cohort (n = 57) with a disease history of Philadelphia-negative MPN including polycythaemia vera, primary myelofibrosis, essential thrombocythemia, or chronic myelomonocytic leukemia (CMML). Seven (12.2%) patients presented with a pattern of diffuse glomerulosclerosis not attributable to diabetic or hypertensive nephropathy. Weak C4d staining suggestive for chronic thrombotic microangiopathy (TMA) was observed in 4/7 cases. Glomerulonephritis was excluded by light microscopy and immunohistochemistry. Patients with a pattern of diffuse glomerulosclerosis did not differ from the rest of the cohort regarding MPN subtype, disease duration, age, or sex. No significant proteinuria had been observed before death. Further findings attributed to MPNs were extramedullary hematopoiesis (n = 5; 8.8%) and tumor involvement in advanced disease (n = 4; 7.0%). Other common findings included arteriolosclerosis (n = 18; 31.6%) and signs of shock (n = 8; 14.0%). To our knowledge, this study is so far the largest investigating renal findings in MPN patients. There may be a causal relationship between idiopathic diffuse glomerular sclerosis and MPN, although its clinical significance and pathophysiology remain uncertain with TMA probably being relevant in a subgroup of cases. Our findings demonstrate the spectrum of renal findings in MPN from early to terminal disease of which hematologists should be aware of in daily clinical practice.
Fire-mediated germination syndromes in Leucadendron (Proteaceae) and their functional correlates
Authors: Newton Rosemary J. , Mackenzie Berin D. E. , Lamont Byron B. , Gomez-Barreiro Pablo , Cowling Richard M. , He Tianhua
Published: June 2021

A mechanistic understanding of fire-driven seedling recruitment is essential for effective conservation management of fire-prone vegetation, such as South African fynbos, especially with rare and threatened taxa. The genusLeucadendron(Proteaceae) is an ideal candidate for comparative germination studies, comprising 85 species with a mixture of contrasting life-history traits (killed by fire vs able to resprout; serotinous vs geosporous) and seed morphologies (nutlets vs winged achenes). Individual and combined effects of heat and smoke on seed germination of 40 species were quantified in the laboratory, and Bayesian inference applied to distinguish biologically meaningful treatment effects from non-zero, but biologically trivial, effects. Three germination syndromes were identified based on whether germination was dependent on, enhanced by, or independent of direct fire cues (heat and smoke). Seed storage location was the most reliable predictor of germination syndromes, with soil-stored seeds c. 80% more likely to respond to direct fire cues (primarily smoke) than canopy-stored seeds. Notable exceptions wereL. linifolium, with an absolute requirement for smoke to germinate (the third serotinous species so reported), and two other serotinous species with smoke-enhanced germination. Nutlet-bearing species, whether serotinous or geosporous, were c. 70% more likely to respond to fire cues than winged seeds, but there was no evidence for an effect of phylogeny or persistence strategy on germination. This comprehensive account of seed germination characteristics and identification of germination syndromes and their predictors, supports propagation, conservation and restoration initiatives in this iconic fynbos genus and other fire-prone shrubs with canopy or soil-stored seeds.
Rapid and sensitive mycoplasma detection system using image-based deep learning
Authors: Iseoka Hiroko , Sasai Masao , Miyagawa Shigeru , Takekita Kazuhiro , Date Satoshi , Ayame Hirohito , Nishida Azusa , Sanami Sho , Hayakawa Takao , Sawa Yoshiki
Published: June 2021

A major concern in the clinical application of cell therapy is the manufacturing cost of cell products, which mainly depends on quality control. The mycoplasma test, an important biological test in cell therapy, takes several weeks to detect a microorganism and is extremely expensive. Furthermore, the manual detection of mycoplasma from images requires high-level expertise. We hypothesized that a mycoplasma identification program using a convolutional neural network could reduce the test time and improve sensitivity. To this end, we developed a program comprising three parts (mycoplasma detection, prediction, and cell counting) that allows users to evaluate the sample and verify infected/non-infected cells identified by the program. In experiments conducted, stained DNA images of positive and negative control using mycoplasma-infected and non-infected Vero cells, respectively, were used as training data, and the program results were compared with those of conventional methods, such as manual counting based on visual observation. The minimum detectable mycoplasma contaminations for manual counting and the proposed program were 10 and 5 CFU (colony-forming unit), respectively, and the test time for manual counting was 20 times that for the proposed program. These results suggest that the proposed system can realize a low-cost and streamlined manufacturing process for cellular products in cell-based research and clinical applications.
Business cycle and mortality in Spain
Authors: Cervini-Plá María , Vall-Castelló Judit
Published: June 2021

In the last couple of decades, there has been a lot of interest on the impact of macroeconomic fluctuations on health and mortality rates. Many studies, for different countries, find that mortality is procyclical. However, studies examining the effects of more recent recessions are less conclusive, finding mortality to be less procyclical, or even countercyclical. In this paper, using data of Spanish provinces from 1999 to 2016, we investigate how this relationship works in the context of a country that is subject to extreme business cycle fluctuations. Furthermore, we analyze the impact of unemployment for different mortality causes and we explore differences by sex, age group and level of education. In general terms, we find mortality to be procyclical so that when the economy is in a recession, mortality falls. When exploring mortality causes, we show that deaths from cardiovascular disease, cancer, senility, transport accidents and homicides are procyclical. By sex, we find procyclicality for both men and women. By age, mortality is procyclical for all age groups; however, the causes of death that result in this procyclical behavior are specific to each age group. By educational level, suicide appears as a countercyclical cause for individuals with intermediate levels of education.
Modification of Airflow Structure Due to Wave Breaking on a Submerged Topography
Authors: Vollestad Petter , Jensen Atle
Published: June 2021

Experimental results from a combined wind–wave tank are presented. Wind profiles and resulting wind–wave spectra are described, and an investigation of the airflow above breaking waves is presented. Monochromatic waves created by the wave maker are directed towards a submerged topography. This causes the waves to break at a predictable location, facilitating particle-image-velocimetry measurements of the airflow above steep breaking and non-breaking waves. We analyze how the breaking state modifies the airflow structure, and in particular the extent of the sheltered area on the leeward side of the waves. Results illustrate that while the geometrical properties of the waves greatly influence the airflow structure on the leeward side of the waves, the state of breaking (i.e., whether the waves are currently in a state of active breaking) is not observed to have a clear effect on the extent of the separated flow region, or on the velocity distribution within the sheltered region.
Quantification of myocardial ischemia and subtended myocardial mass at adenosine stress cardiac computed tomography: a feasibility study
Authors: van Driest F. Y. , van der Geest R. J. , Broersen A. , Dijkstra J. , el Mahdiui M. , Jukema J. W. , Scholte A. J. H. A.
Published: June 2021

Combination of coronary computed tomography angiography (CCTA) and adenosine stress CT myocardial perfusion (CTP) allows for coronary artery lesion assessment as well as myocardial ischemia. However, myocardial ischemia on CTP is nowadays assessed semi-quantitatively by visual analysis. The aim of this study was to fully quantify myocardial ischemia and the subtended myocardial mass on CTP. We included 33 patients referred for a combined CCTA and adenosine stress CTP protocol, with good or excellent imaging quality on CTP. The coronary artery tree was automatically extracted from the CCTA and the relevant coronary artery lesions with a significant stenosis (≥ 50%) were manually defined using dedicated software. Secondly, epicardial and endocardial contours along with CT perfusion deficits were semi-automatically defined in short-axis reformatted images using MASS software. A Voronoi-based segmentation algorithm was used to quantify the subtended myocardial mass, distal from each relevant coronary artery lesion. Perfusion defect and subtended myocardial mass were spatially registered to the CTA. Finally, the subtended myocardial mass per lesion, total subtended myocardial mass and perfusion defect mass (per lesion) were measured. Voronoi-based segmentation was successful in all cases. We assessed a total of 64 relevant coronary artery lesions. Average values for left ventricular mass, total subtended mass and perfusion defect mass were 118, 69 and 7 g respectively. In 19/33 patients (58%) the total perfusion defect mass could be distributed over the relevant coronary artery lesion(s). Quantification of myocardial ischemia and subtended myocardial mass seem feasible at adenosine stress CTP and allows to quantitatively correlate coronary artery lesions to corresponding areas of myocardial hypoperfusion at CCTA and adenosine stress CTP.
Center-Based Child Care and Differential Improvements in the Child Development Outcomes of Disadvantaged Children
Authors: Reynolds Sarah Anne
Published: June 2021

Background

Research finds center-based child care typically benefits children of low socio-economic status (SES) but few studies have examined if it also reduces inequalities in developmental disadvantage.

Objective

I test if the length of time in center-based care between ages one and three years associates with child development scores at age three years, focusing on the impact for groups of children in the lower tercile of child development scores and in the lower SES tercile.

Method

Using data from 1,606 children collected in a nationally representative Chilean survey, I apply a value-added approach to measure gains in child development scores between age one and three years that are associated with length of time in center-based child care.

Results

Disadvantages at age one year were associated with lower child development scores at age three years. No benefits of additional time in center-based care were found for the non-disadvantaged group, but positive associations were found between more time in center-based care and child development outcomes for children with the SES disadvantage only. Center-based care was not associated with child development trajectories of children with lower child development scores at age one year, no matter their SES status.

Conclusions

There is evidence that Chilean center-based child care reduces SES inequality in child development scores between ages one and three years, but only if children already were not low-scorers at age one year.
Actions in Slow Motion: Theoretical and Methodological Reflections on Temporality in Actions and Intersubjective Understanding
Authors: Schmidl Alexander
Published: June 2021

This article examines the connection between actions, temporality, and media-based observation. Slow motion technology is currently being used especially in sports to examine and evaluate athletes’ actions more precisely in order to identify potential infringements of rules. Starting with a phenomenological perspective, this article engages in a critical assessment of the degree to which the intentions underlying athletes’ actions become clearer if their actions are slowed down using slow motion. It transpires that a more in-depth understanding is not possible because the process of time-stretching using media technology tends to obscure intersubjective understanding. Nevertheless, the use of different playback speeds does increase observers’ sensitivity to the temporality of action and observation. This is particularly the case when greater emphasis is placed on the body and its role in the formation and carrying out of intentions. With the phenomenological view and in special consideration of the body and the subjective intentionality, the paper contributes to a discussion about the connection of time and (inter-)action already led in ethnomethodology and conversation analysis. These findings mark a contribution to empirical social research as well, which is increasingly using video material in action analysis and should take slow motion as a possible augmented but also manipulated access to actions into account adequately. To this end, this article suggests a method for identifying the merits and demerits of using slow motion to analyse actions, and discusses the methodological implications of temporality in observation.
Haematopoietic Stem Cell Transplant for Norovirus-Induced Intestinal Failure in X-linked Agammaglobulinemia
Authors: Shillitoe Ben M. J. , Ponsford Mark , Slatter Mary A. , Evans Jennifer , Struik Siske , Cosgrove Mike , Doull Iolo , Jolles Stephen , Gennery Andrew R.
Published: June 2021

Since the first clinical description in 1952, immunoglobulin replacement therapy remains the mainstay of treatment of patients with X-linked agammaglobulinemia (XLA). However, this therapy only replaces IgG isotype and does not compensate for the loss of Bruton tyrosine kinase in non-B-lymphocytes. Patients may still therefore develop complications despite current standard of care. Here, we describe an XLA patient with persistent chronic norovirus infection, refractory to treatment and causing intestinal failure. The patient underwent haematopoietic stem cell transplantation, curing XLA and allowed clearance of norovirus prior to humoral immunoreconstitution, suggesting non-humoral immunodeficiency in these patients.
Physicochemical properties of Mn1.45Co1.45Cu0.1O4 spinel coating deposited on the Crofer 22 H ferritic steel and exposed to high-temperature oxidation under thermal cycling conditions
Authors: Mazur Łukasz , Molin Sebastian , Dąbek Jarosław , Durczak Karol , Pyzalski Michał , Brylewski Tomasz
Published: June 2021

The Crofer 22 H ferritic steel substrate was coated with an Mn1.45Co1.45Cu0.1O4 spinel by means of electrophoresis. After high-temperature oxidation under thermal cycling conditions, the physicochemical properties of the obtained system were evaluated. During 48-h cycles that involved heating the samples up to temperatures of either 750 or 800 °C, the oxidation kinetics of both coated and unmodified steel approximately obeyed the parabolic rate law. The unmodified steel was oxidized at a higher rate than the system consisting of the substrate and the coating. In its bulk form, the spinel consisted entirely of the cubic phase and it exhibited high electrical conductivity. The Mn1.45Co1.45Cu0.1O4 coating, on the other hand, was compact and consisted of two phases—the cubic and the tetragonal one—and it was characterized by good adhesion to the metallic substrate. After cyclic oxidation studies conducted for the two investigated temperatures (750 or 800 °C), the coating was determined to provide a considerable improvement in the electrical properties of the Crofer 22 H ferritic steel, as demonstrated by the area-specific resistance values measured for the steel/coating system. The evaporation rate of chromium measured for these samples likewise indicates that the coating is capable of acting as an effective barrier against the formation of volatile compounds of chromium. The Mn1.45Co1.45Cu0.1O4 spinel can therefore be considered a suitable material for a coating on the Crofer 22 H ferritic steel, with intermediate-temperature solid oxide electrolyzer cells as the target application.
An integrated framework of coastal flood modelling under the failures of sea dikes: a case study in Shanghai
Authors: Ke Qian , Yin Jiangshan , Bricker Jeremy D. , Savage Nicholas , Buonomo Erasmo , Ye Qinghua , Visser Paul , Dong Guangtao , Wang Shuai , Tian Zhan , Sun Laixiang , Toumi Ralf , Jonkman Sebastiaan N.
Published: June 2021

Climate change leads to sea level rise worldwide, as well as increases in the intensity and frequency of tropical cyclones (TCs). Storm surge induced by TC’s, together with spring tides, threatens to cause failure of flood defenses, resulting in massive flooding in low-lying coastal areas. However, limited research has been done on the combined effects of the increasing intensity of TCs and sea level rise on the characteristics of coastal flooding due to the failure of sea dikes. This paper investigates the spatial variation of coastal flooding due to the failure of sea dikes subject to past and future TC climatology and sea level rise, via a case study of a low-lying deltaic city- Shanghai, China. Using a hydrodynamic model and a spectral wave model, storm tide and wave parameters were calculated as input for an empirical model of overtopping discharge rate. The results show that the change of storm climatology together with relative sea level rise (RSLR) largely exacerbates the coastal hazard for Shanghai in the future, in which RSLR is likely to have a larger effect than the TC climatology change on future coastal flooding in Shanghai. In addition, the coastal flood hazard will increase to a large extent in terms of the flood water volume for each corresponding given return period. The approach developed in this paper can also be utilized to investigate future flood risk for other low-lying coastal regions.
On a poset of quantum exact promise problems
Authors: Combarro Elías F. , Vallecorsa Sofia , Meglio Alberto Di , Piñera Alejandro , Rúa Ignacio Fernández
Published: June 2021

Two of the most well-known quantum algorithms, those introduced by Deutsch–Jozsa and Bernstein–Vazirani, can solve promise problems with just one function query, showing an oracular separation with deterministic classical algorithms. In this work, we generalise those methods to study a family of quantum algorithms that can, with just one query, exactly solve promise problems stated over Boolean functions. We also show that these problems can be naturally ordered, inducing a partially ordered set of promise problems. We study the properties of such a poset, showing that the Deutsch–Jozsa and Bernstein–Vazirani problems are, in a certain sense, extremal problems in it, determining some of its automorphisms and proving that it is connected. We also prove that, for the problems in the poset, the corresponding classical query complexities can take any value between 1 and $$2^{n-1}+1$$

2

n
-
1

+
1

.
Blood–brain barrier leakage at baseline and cognitive decline in cerebral small vessel disease: a 2-year follow-up study
Authors: Kerkhofs Danielle , Wong Sau May , Zhang Eleana , Uiterwijk Renske , Hoff Erik I. , Jansen Jacobus F. A. , Staals Julie , Backes Walter H. , van Oostenbrugge Robert J.
Published: June 2021

Blood–brain barrier (BBB) dysfunction is one of the pathophysiological mechanisms in cerebral small vessel disease (SVD). Previously, it was shown that BBB leakage volume is larger in patients with SVD compared with controls. In this study, we investigated the link between BBB leakage and cognitive decline over 2 years in patients with cSVD. At baseline, 51 patients with clinically overt cSVD (lacunar stroke or mild vascular cognitive impairment) received a dynamic contrast-enhanced MRI scan to quantify BBB permeability in the normal-appearing white matter (NAWM), white matter hyperintensities (WMH), cortical grey matter (CGM), and deep grey matter (DGM). Cognitive function in the domain executive function, information processing speed, and memory was measured in all patients at baseline and after 2 years. The association between baseline BBB leakage and cognitive decline over 2 years was determined with multivariable linear regression analysis, corrected for age, sex, educational level, baseline WMH volume, and baseline brain volume. Regression analyses showed that higher baseline leakage volume and rate in the NAWM and CGM were significantly associated with increased overall cognitive decline. Furthermore, higher baseline leakage volume in the NAWM and CGM, and higher baseline leakage rate in the CGM were significantly associated with increased decline in executive function. This longitudinal study showed that higher BBB leakage at baseline is associated with stronger cognitive decline, specifically in executive function, over 2 years of follow-up in patients with cSVD. These results emphasize the key role of BBB disruption in the pathophysiology and clinical progression of cSVD.
Speed-of-sound imaging using diverging waves
Authors: Rau Richard , Schweizer Dieter , Vishnevskiy Valery , Goksel Orcun
Published: June 2021

Purpose.

Due to its safe, low-cost, portable, and real-time nature, ultrasound is a prominent imaging method in computer-assisted interventions. However, typical B-mode ultrasound images have limited contrast and tissue differentiation capability for several clinical applications.

Methods.

Recent introduction of imaging speed-of-sound (SoS) in soft tissues using conventional ultrasound systems and transducers has great potential in clinical translation providing additional imaging contrast, e.g., in intervention planning, navigation, and guidance applications. However, current pulse-echo SoS imaging methods relying on plane wave (PW) sequences are highly prone to aberration effects, therefore suboptimal in image quality. In this paper we propose using diverging waves (DW) for SoS imaging and study this comparatively to PW.

Results.

We demonstrate wavefront aberration and its effects on the key step of displacement tracking in the SoS reconstruction pipeline, comparatively between PW and DW on a synthetic example. We then present the parameterization sensitivity of both approaches on a set of simulated phantoms. Analyzing SoS imaging performance comparatively indicates that using DW instead of PW, the reconstruction accuracy improves by over 20% in root-mean-square-error (RMSE) and by 42% in contrast-to-noise ratio (CNR). We then demonstrate SoS reconstructions with actual US acquisitions of a breast phantom. With our proposed DW, CNR for a high contrast tumor-representative inclusion is improved by 42%, while for a low contrast cyst-representative inclusion a 2.8-fold improvement is achieved.

Conclusion.

SoS imaging, so far only studied using a plane wave transmission scheme, can be made more reliable and accurate using DW. The high imaging contrast of DW-based SoS imaging will thus facilitate the clinical translation of the method and utilization in computer-assisted interventions such as ultrasound-guided biopsies, where B-Mode contrast is often to low to detect potential lesions.
“Journey into hell […where] migrants froze to death”; a critical stylistic analysis of European newspapers’ first response to the 2019 Essex Lorry deaths
Authors: Gregoriou Christiana , Ras Ilse A. , Muždeka Nina
Published: June 2021

In the early hours of October 23rd, 2019, 39 people were found dead in a refrigerated lorry in Grays, Essex, UK. This case attracted media interest across the world; in the 48-h period after the story broke, reporting on this discovery extended to newspapers not just in the UK, but also across Europe. This study uses elements of Critical Stylistics (Jeffries 2010) to analyse and compare first response articles published by European dailies in relation to the event at Grays, to address the nature of this reporting. We found that linguistic choices tend to dramatise what happened, criminalise victims, and even presume the driver’s innocence, with the international criminal network he is presupposed to be part of remaining only speculated on. Though there are attempts to distribute some accountability to governments and policies, as well as structural systemic factors such as war and poverty, responsibility for these factors tends to be diffused, and hence unallocated, this helping ultimately justify draconic law enforcement and border security policies. By highlighting linguistic trends and underlying ideologies which we in turn question, we address the need to tend to the structural causes of such transnational people movement-related crime (i.e. trafficking and smuggling) and shift accountability to governments.
The Impact of Strategic Core-Component Reuse on Product Life Cycles
Authors: Mihale-Wilson Cristina , Felka Patrick , Hinz Oliver , Spann Martin
Published: June 2021

The mobile games business is an ever-increasing sub-sector of the entertainment industry. Due to its high profitability but also high risk and competitive atmosphere, game publishers need to develop strategies that allow them to release new products at a high rate, but without compromising the already short lifespan of the firms' existing games. Successful game publishers must enlarge their user base by continually releasing new and entertaining games, while simultaneously motivating the current user base of existing games to remain active for more extended periods. Since the core-component reuse strategy has proven successful in other software products, this study investigates the advantages and drawbacks of this strategy in mobile games. Drawing on the widely accepted Product Life Cycle concept, the study investigates whether the introduction of a new mobile game built with core-components of an existing mobile game curtails the incumbent's product life cycle. Based on real and granular data on the gaming activity of a popular mobile game, the authors find that by promoting multi-homing (i.e., by smartly interlinking the incumbent and new product with each other so that users start consuming both games in parallel), the core-component reuse strategy can prolong the lifespan of the incumbent game.
Automated Breast Ultrasound: Technical Aspects, Impact on Breast Screening, and Future Perspectives
Authors: Allajbeu Iris , Hickman Sarah E , Payne Nicholas , Moyle Penelope , Taylor Kathryn , Sharma Nisha , Gilbert Fiona J
Published: June 2021

Purpose of Review

Automated breast ultrasound (ABUS) is a three-dimensional imaging technique, used as a supplemental screening tool in women with dense breasts. This review considers the technical aspects, pitfalls, and the use of ABUS in screening and clinical practice, together with new developments and future perspectives.

Recent Findings

ABUS has been approved in the USA and Europe as a screening tool for asymptomatic women with dense breasts in addition to mammography. Supplemental US screening has high sensitivity for cancer detection, especially early-stage invasive cancers, and reduces the frequency of interval cancers. ABUS has similar diagnostic performance to handheld ultrasound (HHUS) and is designed to overcome the drawbacks of operator dependence and poor reproducibility. Concerns with ABUS, like HHUS, include relatively high recall rates and lengthy reading time when compared to mammography. ABUS is a new technique with unique features; therefore, adequate training is required to improve detection and reduce false positives. Computer-aided detection may reduce reading times and improve cancer detection. Other potential applications of ABUS include local staging, treatment response evaluation, breast density assessment, and integration of radiomics.

ABUS provides an efficient, reproducible, and comprehensive supplemental imaging technique in breast screening. Developments with computer-aided detection may improve the sensitivity and specificity as well as radiologist confidence and reduce reading times, making this modality acceptable in large volume screening centers.
Routines: towards the Complexity of Organizational Intentionality
Authors: Makowski Piotr Tomasz
Published: June 2021

The paper explores the topic of organizational routines from a philosophical vantage point to see how the philosophy of action may help improve its understanding in organizational research. The main goal is to show the distinctive complexity of the intentional picture of routines. In this respect, the paper clarifies the interrelations between psychological habits and routines and describes similarities and differences between them. It also highlights the special place of mindfulness as a psycho-cognitive mechanism of action meta-control in intentional explanations of routine complexity.
Coupler force reduction method for multiple-unit trains using a new hierarchical control system
Authors: Jackiewicz Jacek
Published: June 2021

During traction and braking of multiple-unit trains, substantial longitudinal dynamic forces might occur in couplers due to the non-optimal distribution of traction and braking forces generated by self-propelled carriages. These dynamic forces might create shocks affecting the reduction of endurance of the weakest train structural components primarily. Thus, the overall operational safety of the train is also lowered. The purpose of the paper is to develop a new control system to supervise the activities related to the longitudinal dynamics of each train carriage in a multiple-unit train to reduce the longitudinal coupler forces acting during train traction and braking. The hierarchical structure of the control system consists of two levels. The first master level of control works like standard cruise control. However, the reduction of longitudinal coupler forces is achieved by applying a second level of slave control systems with a control configuration of feedback compensation.
Frequently asked questions and answers (if any) in patients with adrenal incidentaloma
Authors: Ceccato F. , Barbot M. , Scaroni C. , Boscaro M.
Published: June 2021

Purpose

Adrenal incidentalomas (AIs) are incidentally discovered adrenal masses, during an imaging study undertaken for other reasons than the suspicion of adrenal disease. Their management is not a minor concern for patients and health-care related costs, since their increasing prevalence in the aging population. The exclusion of malignancy is the first question to attempt, then a careful evaluation of adrenal hormones is suggested. Surgery should be considered in case of overt secretion (primary aldosteronism, adrenal Cushing’s Syndrome or pheochromocytoma), however the management of subclinical secretion is still a matter of debate.

Methods

The aim of the present narrative review is to offer a practical guidance regarding the management of AI, by providing evidence-based answers to frequently asked questions.

Conclusion

The clinical experience is of utmost importance: a personalized diagnostic-therapeutic approach, based upon multidisciplinary discussion, is suggested.
POI recommendation method using LSTM-attention in LBSN considering privacy protection
Authors: Wang Kun , Wang Xiaofeng , Lu Xuan
Published: June 2021

Aiming at the problems of traditional point of interest (POI), such as sparse data, lack of negative feedback, and dynamic and periodic changes of user preferences, a POI recommendation method using deep learning in location-based social networks (LBSN) considering privacy protection is proposed. First, the idea of Embedding is used to quantify the user information, friend relationship, POI information, and so on, so as to obtain the internal relationship of the location. Then, based on the user's history and current POI check-in sequence set, the long- and short-term attention mechanism (LSA) is constructed, and the quantified information is used as the input of LSA to better capture the user's long-term and short-term preferences. Finally, the social network information and semantic information are fitted in different input layers, and the time and geographical location information of user's historical behavior are used to recommend the next POI for users. Gowalla and Brightkite datasets are used to demonstrate the proposed method. The results show that the performance of the proposed method is better than other comparison methods under different sparsity, location sequence length, and embedding length. When the number of iterations is 500, the recommended method tends to be stable, and the accuracy is 0.27. Moreover, the recommendation time of the proposed method is less than 130 ms, which is better than other comparative deep learning methods.
Robotic embankment
Authors: Jud Dominic , Hurkxkens Ilmar , Girot Christophe , Hutter Marco
Published: June 2021

Automating earth-moving tasks has the potential to resolve labour-shortage, allow for unseen designs and foster sustainability through using on-site materials. In this interdisciplinary project involving robotics and landscape architecture, we combine our previous work on autonomous excavation of free-form shapes, dynamic landscape design and terrain modelling tools into a robotic landscape system. It tightly connects survey, design and fabrication to exchange information in real-time during fabrication. We purposely built a LiDAR survey drone for tight integration. The design environment contains terrain modelling tools to balance cut and fill volumes for material-neutral, on-site construction. Its parametric nature allows it to adapt the geometry to changing site conditions during fabrication. Our autonomous walking excavator is used to create these free-form shapes in natural granular material. We propose an excavation planner for free-form embankments that computes the next excavation location and subsequently the location where the excavated soil should be dumped. This robotic excavation system achieves the world’s first autonomous completion of free-form embankments with high accuracy. A $$20\hbox { m}$$

20

m

long S-shaped and a two-faced embankment with a corner with roughly 0.03–0.05 m average error were created.
Application of improved data-driven diagnostics workflow based on coupled hydro-mechanical model for stimulation candidate selection in a complex carbonate reservoir
Authors: Talebian Seyedeh Hosna , Enayati Najafabadi Mohammad , Fahimifar Ahmad
Published: June 2021

The focus of the present paper is on utilizing a comprehensive diagnostics workflow that combines coupled hydro-mechanical modeling with production data-driven diagnostics for optimization of stimulation candidate selection process. Reservoir fluids production and production-induced depletion affect reservoir mechanical environment due to reduced pore pressure and increased effective stress and the consequent porosity and permeability reduction, depending on rock sensitivity to stress changes. The coupled formation damage index (CFDI) is implemented in the traditional stimulation candidate selection workflow to capture the effect of production-induced stress changes on the near-wellbore permeability over time. The top potential stimulation candidates are recognized based on heterogeneity index, static formation damage index, and the CFDI parameter. CFDI is a dynamic parameter for stimulation candidate selection through estimating time-dependent permeability changes induced by stress state and fluid pressure. Probabilistic type curves and decline curve analysis of candidate wells versus reservoir unit are also applied to complement the stimulation and production enhancement candidate selection.
The Short- and Long-Term Costs of a Severe Drought on Retail Peanut Butter Prices and Consumers
Authors: Dong Xiao , Astill Gregory M.
Published: June 2021

This article investigates the short- and long-term costs of an extreme weather event on retail food prices and consumer expenditures. We utilize the 2011 severe peanut drought as a quasi-natural experiment and find that retail peanut butter prices increased 21.3% as a result of the drought-driven shock in farm peanut production and prices. Moreover, we identify long-term costs due to positive asymmetric price transmission as retail peanut butter prices returned to pre-shock levels much more slowly and remained on average 6.2% higher for 4 years after farm peanut prices returned to pre-shock levels. For consumers, the drought increased peanut butter costs, and the persistence of higher prices in peanut butter led to long-term consumer costs. Peanut butter expenditure on average increased by 4.8% post-shock, with lower-income households increasing expenditures even more. A simple calculation estimates that higher peanut butter prices inflicted a cost of $1.08 billion during the shock, and sticky post-shock peanut butter prices imposed a cost of $628 million to U.S. consumers.
Analysis of call detail records to inform the COVID-19 response in Ghana—opportunities and challenges
Authors: Li Tracey , Bowers Rachel , Seidu Omar , Akoto-Bamfo Gloria , Bessah David , Owusu Victor , Smeets Laurent
Published: June 2021

Telecommunications data are being explored by many countries as a new source of data that can be incorporated into their national statistical systems. In particular, “mobile positioning data” are increasingly being used to study population movements and population distributions. However, the legal, ethical, and technical complexities of working with this type of data often pose many barriers, which can prevent the data from being used at the times when it is most urgently needed. We demonstrate how having a robust public–private partnership framework, a privacy-preserving technical setup, and a communications strategy already in place, prior to an emergency, can enable governments to harness the advantages of telecommunications data at the times when it is most valuable. However, even once these foundations are in place, the challenges of competing priorities, managing expectations, and maintaining communication with data consumers during a pandemic mean that the potential of the data is not automatically translated into direct impact. This highlights the importance of sensitisation exercises, targeted at potential data users, to make clear the potential and limitations of the data, as well as the importance of being able to maintain direct communication with data users. The views expressed in this work belong solely to the authors and should not be interpreted as the views of their institutions.
The Autocrat's Corruption Dilemma
Authors: Carothers Christopher
Published: June 2021

A large body of scholarship shows that autocrats can use corruption strategically to strengthen their political hold, such as by distributing rents to their supporters. However, this scholarship often overlooks how corruption may also politically damage autocrats. I argue that corruption often brings substantial political costs alongside its advantages, resulting in a ‘corruption dilemma’ for autocrats. I show that in recent years, public anger over corruption has led to numerous anti-government protests and has been a major cause of autocrats being ousted from power. How politically costly corruption is depends on factors such as the public's tolerance for corruption, whether the autocrat is accountable to quasi-democratic institutions and whether the autocrat can credibly claim to be fighting corruption. The case of Malaysia illustrates how relying on corrupt practices to stay in power can backfire even in a long-standing authoritarian regime. My analysis advances our understanding of corruption's mixed role in authoritarian durability and authoritarian strategies of rule.
The Allocation of Committee Chairs and the Oversight of Coalition Cabinets in Belgium
Authors: Chiru Mihail , De Winter Lieven
Published: June 2021

The appointment of committee chairs to monitor the actions of ministers belonging to coalition partners has received considerably less attention than other mechanisms of policing the coalition agreement at executive or legislative level. We take a longitudinal perspective focusing on 11 Belgian cabinets (1980–2018) to study the determinants of such appointments and whether there is a substitution effect between shadow chairs, junior ministers and coalition agreements. Our findings indicate that the probability of appointing a shadow committee chair is higher when the ideological distance between the minister's party and the coalition is larger. Other key findings are that ministers facing hostile junior ministers tend to be shadowed by committee chairs as well, while shadow chairs are also more frequent in minimum winning coalitions.
A public health perspective on mental health: lessons for population health in the 21st century
Authors: Lucey James V.
Published: June 2021

In December 2019, clinicians and academics from the disciplines of public health and psychiatry met in Dublin at the Royal College of Surgeons in Ireland (RCSI), to restate their shared commitment to population health. The purpose of this review is to bring our discussion to a wider audience. The meeting could not have been more timely. Six weeks later, the COVID-19 emergency emerged in China and within 12 months it had swept the world. This paper, the contents of which were presented at that meeting in December recommended that future healthcare would be guided more by public health perspectives and informed by an understanding of health economics, population health and the lessons learned by psychiatry in the 20th century. Ultimately two issues are at stake in 21st century healthcare: the sustainability of our healthcare systems and the maintenance of public support for population health. We must plan for the next generation of healthcare. We need to do this now since it is clear that COVID-19 marks the beginning of 21st century medicine.
A product form for the general stochastic matching model
Authors: Moyal Pascal , Bušić Ana , Mairesse Jean
Published: June 2021

We consider a stochastic matching model with a general compatibility graph, as introduced by Mairesse and Moyal (2016). We show that the natural necessary condition of stability of the system is also sufficient for the natural ‘first-come, first-matched’ matching policy. To do so, we derive the stationary distribution under a remarkable product form, by using an original dynamic reversibility property related to that of Adan, Bušić, Mairesse, and Weiss (2018) for the bipartite matching model.
Random additions in urns of integers
Authors: Simper Mackenzie
Published: June 2021

Consider an urn containing balls labeled with integer values. Define a discrete-time random process by drawing two balls, one at a time and with replacement, and noting the labels. Add a new ball labeled with the sum of the two drawn labels. This model was introduced by Siegmund and Yakir (2005) Ann. Prob.33, 2036 for labels taking values in a finite group, in which case the distribution defined by the urn converges to the uniform distribution on the group. For the urn of integers, the main result of this paper is an exponential limit law. The mean of the exponential is a random variable with distribution depending on the starting configuration. This is a novel urn model which combines multi-drawing and an infinite type of balls. The proof of convergence uses the contraction method for recursive distributional equations.
The impact of coronavirus disease 2019 on suspected head and neck cancer two-week-wait referrals
Authors: Bhamra N , Gorman B , Arnold W , Rajah A , Jolly K , Nieto H , Fussey J , Liew L
Published: June 2021

Background

The impact of coronavirus disease 2019 extends far beyond the immediate burden on healthcare systems caused by hospitalisation of patients with the disease itself.

Objective

To investigate the impact of the coronavirus disease 2019 pandemic on the referral rate of patients to the suspected head and neck cancer two-week-wait clinic.

Methods

A multicentre retrospective study was performed investigating data collected for all patients attending the suspected head and neck cancer two-week-wait clinic in ENT departments in the West Midlands.

Results

A total of 509 fast-track referrals were received from February to April in 2019, compared to 399 referrals in 2020. April 2020 saw a 62.4 per cent reduction in referral rate compared to April 2019.

Conclusion

The coronavirus disease 2019 pandemic has resulted in changes to health-seeking behaviours, and healthcare provision and delivery. Urgent policy interventions may be required to compensate for the hidden impact that the coronavirus disease 2019 pandemic has had on those with cancer.
Advanced soft robot modeling in ChainQueen
Authors: Spielberg Andrew , Du Tao , Hu Yuanming , Rus Daniela , Matusik Wojciech
Published: June 2021

We present extensions to ChainQueen, an open source, fully differentiable material point method simulator for soft robotics. Previous work established ChainQueen as a powerful tool for inference, control, and co-design for soft robotics. We detail enhancements to ChainQueen, allowing for more efficient simulation and optimization and expressive co-optimization over material properties and geometric parameters. We package our simulator extensions in an easy-to-use, modular application programming interface (API) with predefined observation models, controllers, actuators, optimizers, and geometric processing tools, making it simple to prototype complex experiments in 50 lines or fewer. We demonstrate the power of our simulator extensions in over nine simulated experiments.
Autonomous vehicle self-localization in urban environments based on 3D curvature feature points – Monte Carlo localization
Authors: Liu Qi , Di Xiaoguang , Xu Binfeng
Published: June 2021

This paper proposes a map-based localization system for autonomous vehicle self-localization in urban environments, which is composed of a pose graph mapping method and 3D curvature feature points – Monte Carlo Localization algorithm (3DCF-MCL). The advantage of 3DCF-MCL is that it combines the high accuracy of the 3D feature points registration and the robustness of particle filter. Experimental results show that 3DCF-MCL can provide an accurate localization for autonomous vehicles with the 3D point cloud map that generated by our mapping method. Compared with other map-based localization algorithms, it demonstrates that 3DCF-MCL outperforms them.