bluuebunny/crossref_metadata_2025 huggingface dataset:
Proximicin A-C as prospective HER2-positive and negative breast cancer drugs: Molecular docking and in silico ADME modeling (Preprint)
Authors: Aung Thet htwe
Published: April 2022

BACKGROUND

Breast cancer is the second leading cause of cancer related death among women worldwide. Proximicin A-C are bioactive chemicals produced by the marine Verrucosispora strain, which have been shown to have potent cytostatic effect against human breast cancer [MCF 7]. HER2 (Human epidermal growth factor receptor 2) is a gene that has been linked to breast cancer development.

OBJECTIVE

The study’s goals are to (1) forecast the intensity of binding affinity and interactions between HER2 and proximicin A-C, and (2) analyze ADME characteristics of proximicin A-C (Absorption, Distribution, Metabolism, and Excretion).

METHODS

The CB-Dock web service was used to dock proximicin A-B and commonly used breast cancer medicines Neratinib (Nerlynx) and Talazoparib against HER2, and protein-ligand interaction findings were collected via the protein-ligand interaction profiler (PLP) web server. The SwissADME web server was used to investigate ADME properties of the substances.

RESULTS

In terms of docking, proximicin A has a vina score of -8.6, proximicin B and C has a score of -10, Talazoparib has a vina score of -8.5, and Neratinib (Nerlynx) has a vina score of -10.2 on CB-Dock. This means that proximicin B and C bind to HER2 more strongly than proximicin A and Talazoparib. Furthermore, their high binding affinity is equivalent to Neratinibs (Nerlynx). Talazoparib has a lower binding affinity for HER2 than proximicin A. With HER2, all three chemicals have a strong hydrogen bond and hydrophobic contact. SwissADME estimated that all three substances follow the Lipinski rule (RO5) and have a bioavailability score of 0.55. They don’t have any structural issue in medicinal chemistry (no alerts in PAINS and Brenk forecasts), and their synthetic accessibility scales range from 3 to 3.5. Only proximicin A, on the other hand, has the leadlikeness feature. All three drugs failed to cross the blood-brain barrier (BBB) in terms of pharmacokinetics. Proximicin A has a high absorption rate in the GI tract, whereas proximicin B-C has a low absorption rate in the GI tract (GI). Similarly, proximicin A is neither a P-gp substrate nor a CYP1A2, CYP2C19, CYP2C9, CYP2D6, or CYP3A4 inhibitor. Proximicin B-C, on the other hand, are P-gp substrates, and proximicin C is an inhibitor of all provided CYP enzymes, whilst proximicin B inhibits only three.

CONCLUSIONS

Overall, proximicin A-B could be used as a possible breast cancer therapeutic candidate. Proximicin B-C will outperform proximicin A in terms of therapeutic efficacy. Proximicin A, on the other hand, will have better ADME qualities than Proximicin B-C.

CLINICALTRIAL

This study will provide the lead information for developing a new breast cancer medication with a good pharmacological profile.
The state of microcirculation, the hemostasis system, and level of proteins irisin and CCL11 in young and old rats
Authors:   Federal State Budgetary Educational Institution of Higher Educa tion ", Manaeva Irina N. ,   Altai State Medical University", Bondarchuk Yulia A. ,   Federal State Budgetary Educational Institution of Higher Educa tion "Altai State Medical University", Shakhmatov Igor I. ,   Federal State Budgetary Educational Institution of Higher Educa tion "Altai State Medical University", Moskalenko Svetlana V. ,   Federal State Budgetary Educational Institution of Higher Educa tion "Altai State Medical University", Bobrov Igor P. ,   Federal State Budgetary Educational Institution of Higher Educa tion "Altai State Medical University", Marshalkina Polina S. ,   Federal State Budgetary Educational Institution of Higher Educa tion "Altai State Medical University", Prokopets Daria A. ,   Federal State Budgetary Educational Institution of Higher Educa tion "Altai State Medical University"
Published: April 2022

A significant role in the development of cardiovascular pathology in old age belongs to age-related changes in the microvasculature and the hemostatic system. The development of age-related diseases is influenced by both the level and the ratio of the proteins «youth» (irisin) and «old age» (CCL11). To carry out effective prevention of the occurrence of these diseases, it is necessary to study the characteristics of the functioning of an aging organism. The aim is to assess the state of the microvasculature, the hemostasis system, the level of the proteins irisin and the chemokine CCL11 in young and old rats. Young and old male rats (28 individuals) of the Wistar line were used in the experiment. The state of the microvasculature, the hemostasis system of animals, the level of the proteins irisin and CCL11 were studied. In old rats, compared with young animals, at the microcirculatory level, spasm of arterioles was observed on the background of a decrease in nutritional blood flow. An increase in the aggregation activity of platelets in aged animals was accompanied by hypercoagulation, recorded using clotting and global techniques, as well as a decrease in the anticoagulant activity of blood plasma and activation of fibrinolysis. In addition, in older animals, a decrease in the level of the irisin protein was recorded, while the chemokine CCL11 increased. So, with increasing age, there is a significant deterioration in the state of the microvasculature, hypercoagulative shifts in the hemostasis system and unfavorable changes in the level and ratio of proteins of "outh" and "old age".
PRECISE MEASUREMENT OF ORBITAL AND PHYSICAL PARAMETERS OF BRIGHT DETACHED SOLAR ANALOG ECLIPSING BINARIES
Authors: Çakırlı Ö , Hoyman B. , Bulut S. , Derviçoğlu A. , Kayhan C.
Published: April 2022

We combined photometry from the All Sky Automated Survey (ASAS) and the Transiting Exoplanet Survey Satellite (TESS) with high-resolution spectroscopy from the ESO public archive to obtain, for the first time, absolute physical and orbital parameters for six double-lined detached eclipsing binary systems with solar-type components. The atmospheric parameters of the stars have been determined from the individual spectra obtained from a disentangling method. One of the targets resulted in a triple system, and lines coming from three components in spectra show that each component's contribution to the total light is approximately equal. For the six systems the masses and radii of the components were obtained with a precision better than 3%. A comparison of the observed stellar parameters with the prediction of stellar evolution based on the MESA stellar evolution code shows reasonable agreement.
A STUDY ON DIFFERENT ATTITUDE STRATEGIES AND MISSION PARAMETERS BASED ON LIGHTSAIL-2
Authors: Meireles L. G. , Prado A. F. B. A. , de Melo C. F. , Pereira M. C.
Published: April 2022

The Planetary Society's LightSail-2 mission successfully validated the orbital maneuvering capability of a solar radiation pressure (SRP) propelled spacecraft. This paper presents a study on two alternative attitude strategies for the orientation of a solar sail. The goal is to increase the effect of the SRP acceleration over the spacecraft's orbital trajectory, with the intention of maintaining or even gaining altitude over time. Furthermore, one of these strategies was employed while varying a few of the mission's parameters to determine if it would be viable to maintain the spacecraft's average altitude. Results show that it is possible to increase the average altitude of the spacecraft over time while still reducing the number of maneuvers necessary to change the spacecraft's attitude. With that result in hand, it is also possible to change some of the mission parameters without compromising the solar sailing performance.
FIRST LIGHT CURVE ANALYSIS OF THE MODERATE FILL-OUT CONTACT BINARY SYSTEMS TYC 2402-643-1, TYC 2703-1235-1 AND TYC 2913-2145-1
Authors: Barani C. , Acerbi F. , Popov V.
Published: April 2022

We present the results of our study of the W Ursae Majoris eclipsing binary systems (EW) TYC 2402-643-1, TYC 2703-1235-1 and TYC 2913-2145-1 based on CCD observations obtained using Sloan g’ and i' filters. The light curves were analysed using the latest version of the Wilson-Devinney code, and the obtained data were used to estimate the physical parameters of the systems. TYC 2402-643-1 and TYC 2913-2145-1, having mass ratio < 0.25, can be classified as Extreme Mass Ratio Binary (EMRBs) systems and belong to the A-subtype class of the EW. The third one, TYC 2703-1235-1, having mass ratio q about 3 (1/q = 0.33) belongs to W-subtype class of the EW. The absolute dimensions of the primaries and secondaries were estimated and investigated using different evolutionary diagrams. The parameters of the progenitors of the components of the systems were calculated and the results are consistent with the determination of the subtypes.
CCD PHOTOMETRY AND EVOLUTIONARY STATUS OF THE HADS VARIABLE PT COM
Authors: Alton K. B.
Published: April 2022

Multi-color (BVIc) CCD-derived photometric data were acquired from PT Com, a pulsating variable classified as a high amplitude δ Scuti-type system. Analysis of precise time-series lightcurve data was accomplished using discrete Fourier transformation which revealed a mean fundamental mode (f0) of oscillation at 12.178364 ± 0.000083 d−1 along with at least three other partial harmonics (2f0, 3f0 and 4f0). No other statistically significant frequency shared by all bandpasses was resolved following successive pre-whitening of each residual signal. A secular analysis of the fundamental pulse period since 1999 was facilitated by the addition of 35 new times-of-maximum. The evolutionary status, age and physical nature of PT Com were investigated using the PAdova & TRieste Stellar Evolution Code for generating stellar tracks and isochrones.
Study on the Strength Characteristics and Mechanism of Weathered TUFF
Authors: Abiola Ajagbe , Li-Quan Wu
Published: April 2022

Abstract: Many countries in the world has a large number of tuff like cultural relics that have many historical history. These kinds of cultural relics tuff have experienced many natural weathering in the long historical years. Natural weathering like air pollution since industrialization, acid rain erosion and many different degrees of artificial damage, they are suffering from different degrees of surface degradation and decay, erosion and even destruction and a strong typhoon effect. Under consideration and effective protective measures are not taken, irreparable losses will be caused. People who are coming for tourism to look at the historical and cultural relics are in danger. Therefore, it is urgent to deeply study the weathering damage mechanism of stone cultural relics, and to develop stone cultural relics protection materials and construction technical measures. In this paper we will research by understanding the theoretical characteristics and relationship between tuff strength and weathering degree and weathering damage mechanism of stone, and characteristics of rock and mineral composition so that we can theoretically address by studying the weathering damage mechanism. Keywords: Natural stone decay; tuff materials, rock mechanics, weathering damage.
Power Genration Using By Peltier Module
Authors: Halmare Mr. Abhay , Zade Shreya Damodhar , Parchake Simran Ramkrushna , Borkar Ritesh Siddharth
Published: April 2022

Abstract: Purpose of making this project is to generate electrical energy from bad materials cow dung , dry paddy fields, dry leaf and bad stuff etc. and store that electrical energy in the battery through the circuit and use that electrical energy to operate the whole project. And the LED bulb is shown to be turned on and the use of filters to control pollution from energy production .So in this our Project we show successfully How to generate electricity by Waste Materials And Store electricity in Battery successfully. The main aim behind this project is to reduce the pollution, and recycle the wastage and reuse them and finally to produce the electricity from waste. Energy harvesting is the main focus of the researchers all over the world. It is because of deployment of million sensor nodes and bottleneck of battery. This method avails various methods like piezoelectric, electromagnetic, solar and thermoelectric. Keywords: LED (Light emitting diode), Electromagnetic, Thermoelectric, Voltage, Sag, Piezoelectric, Power Quality
Adoption of Electrical Vehicles in India
Authors: Bhavsar Sumedh , Gaikwad Saurav , Patil Vedant , Bari Abdul
Published: April 2022

Abstract: Greenhouse gas emission, fast depletion of fossil fuels, the oil crisis and the increased cost of petroleum products are the major factors that need a shift from internal combustion engines to Electric Vehicles. The use of electric cars is an active action in conserving the environment. The use of these cars promotes the protection of the environment by reducing greenhouse gas emissions while promoting renewable energy sources that are less likely to amount to the carbon footprint. Electric cars function by plugging into a charge point and taking electricity from the grid. They store the electricity in rechargeable batteries that power an electric motor, which turns the wheels. Electric cars accelerate faster than vehicles with traditional fuel engines so they feel lighter to drive. India launched "National Electric Mobility Mission Plan (NEMMP) 2020" in 2013, which aims promotion of hybrid and EVs in the country to achieve national energy security. Even after this the total sales of EV's in India was only about 0.0068% of the total sales of vehicles in India. Increasing long-term gasoline price and concerns on the impact of emissions have inspired alternative technologies like electric vehicles (EVs). The automotive manufacturers are facing difficulties in understanding the needs and wants of the customer. This research aims at helping the automobile manufacturers to understand the customer better. The insights gained from this research will help policymakers around the world in crafting transportation and energy policies in the EV transportation system. Lack of study on this topic in India is the reason for a gap in consumer adoption and scientific research EVs. Filling that gap is the motive of this research overall, this project involves processes like design, analysis, fabrication and assembling of different components. Keywords: Electrical Vehicle, Adoption, Design, Analysis, Surveys.
Smart Cities through IoT
Authors: Srivastava Adarsh , Yadav Ankit , Sharma Ashwani , Sharma Sourav , Kumar Mr. Dharmesh
Published: April 2022

Abstract: The enormous utilization of Internet of Things (IoT) is allowing Smart City projects and initiatives all overthe world. The IoT is a modular approach to merge various sensors with all the solutions. Due to the advancements in technologies, smart cities have been considered as a versatile parameter in order to control, monitor and operate in different fields (like electrical fault detection, corporation duties etc.) in an efficient manner without costing much of time and manpower thereby making the city smarter than before. Cities canbe interfaced with Internet of Things(IoT) which finds many applications in the conversion of a city to a Smart City. In this paper, a sincere attempt has been taken to list out the essentials of Smart Cities and to overcome the issues faced by normal cities. Also, the main purpose of this paper is that of providing a detailed review on the concepts of smart cities and their applications in different fields. In particular, this concept describes the IoT technologies for smart cities and the main features of a smart city. Keywords: Internet of Things(IoT), smart city, environment, sensors, electrical system.
A Comparative Study on Hardened Properties of Concrete by Partial Replacement of Cement with Metakaolin by Experimental and ANSYS Approach
Authors: Meshram Rutuja A. , Satone Dr. Swapneel , Kundu Er. Dipartha
Published: April 2022

Abstract: The literature study shows that some industrial waste material such as fly ash, GGBS, silica fume, metakaoline, etc. are good way to exchange cement in concrete and make it durable, strong, economic and environment friendly and also gives strength as per conventional concrete. These materials are often used as supplementary cementitious material because the replacement of cement in various percentages and make it high performance concrete which may be utilized in high rise building, flyovers, bridges, etc In this literature review study metakaoline looks to be promising supplementary cementitious material for high performance concrete. The substitution proportion of metakaoline is to be used was 0%, 10%, 20%, 30%, 40% by the weight of the cement. The cubes were made to check the compressive strength at 7, 28 and 56 days of curing. The results shows the many difference between the replacing mix upto last percent has effect on strength as compared with mix without metakaolin. Keywords: Metakaoline, concrete mix, compressive strength, ANSYS
PENGANGGURAN TERBUKA DAN DETERMINANNYA DI INDONESIA TAHUN 2013-2017
Authors: Salsabella Apsari Demmy , Hidayat Wahyu , Kusuma Hendra
Published: April 2022

The level of open unemployment is the percentage of unemployment to the total labor force. The purpose of this study was to analyze the effect of population, GRDP, and education level on the level of open acquisition in Indonesia in 2013-2017. The type of data used in this study is secondary data, data collection in this study uses multiple linear regression methods. The data used consists of panel data. The population has a negative and significant effect, while the GRDP has a positive and significant effect, and the level of education has a positive and significant effect on the level of open acquisition.
ANALISIS TINGKAT DAYA SERAP ANGGARAN BELANJA DAERAH DI KOTA MALANG
Authors: Krisdiyanawati Luluk , Abdullah Muhammad Faisal , Syaifullah Yunan
Published: April 2022

The purpose of this research is to understand the level of absorptive capacity of regional expenditure budgets in Malang City and to understand the effect  of planning  variables, procurement of goods and services variables, and human sesource variables on the  absorption of regional expenditure budgets in Malang. 
This type of research  is  quantitative  research. The population in this research were 20 regional work units in Malang in the form of Agency and Department. The sample of this research is the Regional  Financial and Asset Agency, Planning Research and Development Agency, Education and Culture Department, Health Department, and Environment Department in Malang City with  respondents occupying positions related to the budget, namely the authority  of  budgets users, officials making commitments, the technical executive officer of the  activity, the official signing the payment order, and the treasurer of the expenditure.
The technical analysis used is multiple linear regression. The results of this research indicated that the human resources variable has a significant  positive effect on the absorption of regional budgets. While the planning variable and the procurement  of goods and services variable do not significantly influence the absorption capacity of the budget
ANALISIS FAKTOR YANG MEMPENGARUHI TINGKAT KEMISKINAN PROVINSI DI PULAU JAWA
Authors: Sari Liya nur , Nuraini Ida
Published: April 2022

Poverty is an issue that must be resolved by a country, especially developing countries. Poverty is also influenced by many factors such as income, health, education, unemployment and access to goods and services. The study research the effect of literacy rate, life expectancy, and an unemployment rate of poverty every province in Java Island in 2014-201. The research uses quantitative method. Data analysis using the panel data model by common effect, fixed effect and random effect. While for the best estimation model using chow test, Hausman test and LM test. The results of this study indicate that the best estimation model this study is a random effect model, which means literacy rate significantly negative effect on poverty, life expectancy significant positive effect on poverty, and unemployment rate significantly positive effect on poverty. Therefore, the government is expected to improve the quality of a strong planning strategy so that is can be achieved the purpose for the welfare of the poor, which is a form of success in developing a country.
ANALISIS FAKTOR YANG MEMPENGARUHI PROFITABILITAS (ROA) BANK SYARIAH DI INDONESIA TAHUN 2014-2018
Authors: Ramadhanty Rizky , Soelistyo Aris
Published: April 2022

Syariah banks is that implement syariah principle in Indonesian. Has introduced banking instutions using syaria system can be a alternative choice for muslim communities in Indonesian. In Indonesia, syariah banks have begun to develop since the issue of law No. 7 year 1992 on banking. As institutions that are important role banks need to pay attention to their performance to operate properly. Performance levels can be assessed using one of the profitability indicators that is Return On Asset (ROA). ROA is a description of the bank’s productivity in managing its funds to get the overall profit. There are indicators related to ROA analysis such as FRD, CAR, BOPO. The purpose of this research is to know the influence of FDR, CAR, BOPO on the profitability of ROA on syariah banks in Indonesian. The method used is multiple regression. Data is processed through e-views. The number of samples used is 13 syariah banks. The result showed the fDR signicantly negative effect on ROA with a coefficient value of -3.77E and a probability of 0.019, CAR has a significant positive effect on ROA with a coefficient value of 0.205 and a value of probability 0.0004, BOPO has a significant negative effect with a coefficient negative effect with a coefficient value of -0.106 and a probability of 0.000. FDR, CAR, BOPO is a simultan effect on ROA
ANALISIS PENGARUH DANA DESA TERHADAP PEMBANGUNAN INFRASTRUKTUR DI KECAMATAN NGLEGOK KABUPATEN BLITAR
Authors: Supriadi Verren Elyviana , Soelistyo Aris , Syaifullah Yunan
Published: April 2022

The purpose of this study is to determine the effect of Village Funds, Capital Expenditures, and Population Amounts for Infrastructure Development in Nglegok District in 2015-2019. This type of research is quantitative descriptive. The type of data used is secondary data obtained from the Office of Community and Village Empowerment (DPMD) in the form of financial statements of the Village Budget (APBDes).Census technique is used to determine the population in this population in this study. The sample of this research is 10 villages in Nglegok District.The data collection technique used is the documentation method. The technical analysis used is panel data regression. The results of this study suggested that the Village Fund variable has a significant positive effect on infrastructure development, the Capital Expenditure variable has a significant positive effect on infrastructure development, and the population has a significant negative effect on infrastructure development in Nglegok District.
Analisis Pengaruh Ekspor dan Impor terhadap Pertumbuhan ekonomi di negara ASEAN tahun 2013-2017
Authors: Pico Nurhaliza
Published: April 2022

Tujuan penelitian ini adalah untuk mengetahui pengaruh ekspor dan impor terhadap pertumbuhan ekonomi (GDP) di negara ASEAN tahun 2013-2017. Jumlah sampel yang digunakan adalah 10 negara. Metode yang digunakan adalah pendekatan kuantitatif menggunakan data sekunder yang diperoleh dari laporan keuangan tahunan dari masing-masing negara. Alat analisis yang digunakan adalah regresi data panel. Data dioalah melalui E-views. Hasil penelitian menunjukan bahwa ekspor dan impor berpengaruh positif signifikan terhadap pertumbuhan ekonomi(GDP). Dalam penelitian ini peneliti memiliki keterbatasan hanya menggunakan 5 tahun dan hanya menggunakan variabel ekspor dan impor sebagai variabel independen sehingga dapat mempengaruhi terhadap hasil penelitian. Untuk peneliti selanjutnya diharapkan dapat mengembangkan jumlah variabel dan dapat menambahkan waktu pengamatan
PENGARUH BI-RATE DAN LOAN TO DEPOSIT RATIO (LDR) TERHADAP KREDIT BERMASALAH PADA BANK UMUM BUMN
Authors: Widiawati Nanda Galuh , Abdullah Muhammad Faisal
Published: April 2022

This study aims to analyze the effect of the BI-Rate and Loan To Deposit Ratio (LDR) on Non Performing-Loans (NPL) at state-owned commercial banks. This study uses secondary data sources obtained using the documentation method. The samples in this study were 4 BUMN banks with saturated or census sampling techniques. The period used in this study was 15 years, from 2005 - 2019. The analysis technique used was Panel Data Regression.The results of the study simultaneously and partially show that the independent variable significantly influences the Non Performing Loan (NPL), the BI-Rate Variable has a significant positive effect on the probability amounting to 0.0119, while the Loan To Deposit Ratio (LDR) variable has a significant negative effect on the probability amounting to 0.0000.
PENGARUH KEMITRAAN USAHA KOPERASI SUSU TERHADAP JUMLAH PENDAPATAN PETERNAK SAPI PERAH DI DESA GEGER KECAMATAN SENDANG KABUPATEN TULUNGAGUNG
Authors: Hardiyanti Endra , Susilowati Dwi , Arifin Zainal
Published: April 2022

A dairy cooperative business is a part of income that has a major impact on the economy of rural communities. In this study, there is a partnership between the Desa Tani Wilis unit and cooperative dairy farmers who are connected to improve the quality of milk so that milk can be further increased to be ready to be marketed to Nestle's milk factory, and increase the income of dairy farmers. The results showed that this partnership was quite successful because of the beneficial partnership for the breeders. The results showed that the initial capital, the number of cows, and the length of time they were members of the cooperative affected the income of dairy farmers. By taking 30 samples in Geger Village, Sendang District, Tulungagung Regency. The method used is SPSS and uses income analysis, multiple regression analysis, and statistical tests. The results of this study indicate that the variables of initial capital, number of cows, and length of time being members of the cooperative have a significant effect on income.
TINGKAT KESEJAHTERAAN PETANI TAMBAK UDANG DI DESA KALISOGO KECAMATAN JABON KABUPATEN SIDOARJO
Authors: Subyantoro Tyamaudy , Nuraini Ida , Kusuma Hendra
Published: April 2022

The purpose of this study was to determine the level of welfare of shrimp farm farmers in Kalisogo Village, Jabon District, Sidoarjo Regency and determine the effect of price variables, production variables, and land area variabels on Farmer exchange rates. This type of research is quantitative research. The population in this study was 187 shrimp farm farmers in Kalisogo Village, Jabon District, Sidoarjo Regency and the sample of this study was 38 respondents in shrimp pond farmers in Kalisogo Village, Jabon District, Sidoarjo Regency.The technical analysis used is multiple linear regression and the farmer exchange rate method. The results of this study indicate that the production variable has a positive effect on the farmer exchange rate variable and the land area variable has a positive effect on the farmer exchange rate variable while the price variable has no significant effect on the farmer exchange rate variable. the farmer exchange rate method if more than 100 then experiences a surplus of the overall yield of 102,84 which means that the farmer exchange rate is fulfilled and can be further developed.
ANALISIS PENGARUH INVESTASI DAN TENAGA KERJA TERHADAP NILAI INDUSTRI SEKTOR INDUSTRI MANUFAKTUR DI JAWA TIMUR TAHUN 1999-2018
Authors: Cans Linda Rukmana , Riyanto Wahyu Hidayat
Published: April 2022

The purpose of this study was to determine the effect of investment and labor on the production value of the manufacturing industry sector in East Java 1999-2018. The number of samples used is 20 years. The method used is a quantitative approach using secondary data obtained from data from the Central Statistics Agency (BPS). The analytical tool used is multiple linear regression. Data is processed through E-views. The results showed that investment and labor had a significant positive effect on the value of production in the manufacturing industry sector. In this study the researcher has a limitation of only using 20 years and only using investment and labor variables as an independent variable so that it can influence the research results. The next researcher is expected to be able to develop the number of variables and be able to add observation time.
ANALISIS FAKTOR YANG BERPENGARUH TERHADAP PENDAPATAN PEDAGANG PASAR MANGLI KABUPATEN JEMBER
Authors: Firdaus Nadir Muhammad kahfi , Boedirochminarni Arfida , Wahyudi Muhammad Sri
Published: April 2022

Many factors influence the income of sellers. This research was aimed to examine the possible factors that affected the amount of income obtained by sellers of Mangli Market. This research was categorized as a descriptive research using quantitative method. This research was conducted in Mangli Market with 163 population of sellers. The samples in this research were 62 respondents taken by using slovin formula technique. Meanwhile the method of data collection were using questionnaires and conducting interview. The variables used included business capital, the duration of business practice, working hours and sellers’ income. The data analysis used was Multiple Linear Regression (OLS) with level of significance of 5%. The result show that the variable of capital significant positive effect of .021 the duration of business practice significant positive effect of .029 ) and working hours significant positive effect of .006 has simultaneously positive effect and significant to income. For individual, capital variable has no effect and significant at the income influence in Mangli Market  Mangli Village. Kaliwates  sub district, Jember districts
PENGARUH INDUSTRI PENGOLAHAN, TENAGA KERJA, DAN INFLASI TERHADAP PERTUMBUHAN EKONOMI DI JAWA TIMUR TAHUN 1981-2018
Authors: Kusumawardani Maya Wulan , Nuraini Ida
Published: April 2022

Economic growth is one indicator that is used as a benchmark for the success of the development of an area in East Java whether it has increased or decreased. This study aims to determine how much influence or variables that can influence economic growth in East Java. The analytical tool used in this study is multiple linear regression with time series data interpolated with statistical measurements using Eviews computer by using the classic assumption test and the F t-test analysis. In the results of research that have been carried out it is known that the processing industry has a positive and significant influence on economic growth in East Java with the results of the coefficient 24.73977 and the probability result of 0.0117 as the labor variable which also has a positive and significant effect with the results obtained the regression coefficient is 45.17394 and the probability result is 0.0229 while the inflation variable has a negative and significant effect on economic growth with the results of the regression coefficient of -0.251741 with a probability  result of 0.0043.
ANALISIS PENGARUH INFLASI, PDRB, DAN UPAH MINIMUM TERHADAP PENYERAPAN TENAGA KERJA DI JAWA TIMUR
Authors: Warapsari Esthi Bhakti , Hidayat Wahyu , Rochminarni Arfida
Published: April 2022

The population growth in Indonesia has been increasing steadily, so has the population growth in East Java Province. An increase in population will lead to an increase in the number of workers. The increasing number of workers will become a problem in the world of employment, if the number of workers available is not proportional to the demand for workers who are able to absorb. The results of this study indicate that the results of the study were negative and insignificant to the workforce in East Java Province with a coefficient of -0,000508 and a probability yield of 0.3650, while the GRDP had a positive and significant effect on labor in the East Java Province with a coefficient of 0,026689 and the probability result of  0.0468, and the minimum wage have a positive and significant effect on labor in the Province of East Java with a coefficient result of 0.132291 and a probability result of  0.0000.
ANALISIS POTENSI PARIWISATA DI PULAU KANGEAN
Authors: Hayani Asmaul , Zuhroh Idah , Cantika Sri Budi
Published: April 2022

This study aims to analyze the tourism potential on Kangean Island as mandated by the Minister of Home Affairs Regulation No. 01 of 2007 explaining that recreational parks are one type of urban green open space (RTHKP). In the Law of the Republic of Indonesia No.10 of 2009 concerning tourism is a variety of facilities and services provided by stakeholders such as the community, entrepreneurs, local governments. Potential tourism in the Kangean islands based on natural tourism with the natural conditions and the quality of the beautiful beaches, this condition really has the opportunity to be developed into a tourist destination Kangean islands. The potential that exists in Kangean Island is identified through five aspects, namely: Uniqueness, diversity, natural wealth, beach quality, and beauty and to find out whether or not it is a tourism tourism area using SWOT analysts by looking at the strengths, weaknesses, opportunities and threats in each tourist spot.. The method used in this research is descriptive qualitative research, and the results of the study show that tourism in Kangean Island is feasible to be developed because its potential is very promising.
PENGARUH JUMLAH INDUSTRI, TENAGA KERJA, DAN PENGELUARAN PEMERINTAH TERHADAP PERTUMBUHAN EKONOMI DI KAWASAN GERBANGKERTASUSILA TAHUN 2014-2018
Authors: Laxa Anggie Triteleiea , Soliestyo Aris
Published: April 2022

GERBANGKERTASUSILA in East Java Province is the highest contributor to GRDP in East Java Province. The purpose of the research itself is to determine the influence of the number of industries, labor, and government spending with economic growth in the GERBANGKERTASUSILA region in 2014-2018. In this study, the Gross Regional Domestic Product (GRDP) data on the number of industries, labor in the industrial sector, and government expenditure in the industrial sector over a period of five years is 2014-2018. The method in this study uses Panel Data which is a combination of time series data (2014-2018) and cross data (seven regencies / cities) in East Java Province as well as the Random Effect approach model. The data analysis of this study used multiple linear regression with the source of the data obtained from BPS (Statistics Indonesia) which then processed the data using Eviews-9. The results of this study indicate that each variable of the number of industries, labor, and government spending has a significant and positive influence on economic growth in the GERBANGKERTASUSILA region in 2014-2018.
Analisis Pengangguran Terbuka Di Provinsi Jawa Tengah Tahun 2015-2019
Authors: Anggraini Zila Anggraini
Published: April 2022

Unemployment is one of the problems in economic development in every country. If the amount of eviction is high, it can cause social insecurity and worsen existing poverty. This study aims to determine the effect of Education Level and PMDN on Open Unemployment in Districts and Cities of Central Java Province in the period 2015-2019. Analysis techniques using the data panel regression analysis method and traditional assumptions using the Eviews 9 tool. This study showed that simultaneously the variable Level of Education and PMDN had a significant effect on Open Unemployment in Districts and Cities of Central Java Province in 2015-2019. At the same time, partially variable Education Level has a significant negative effect on Open Unemployment in districts and cities of Central Java Province. The variable Domestic Investment (PMDN) has an insignificant positive impact on Open Unemployment in Districts and Cities of Central Java Province in 2015-2019.
Analisis Faktor-Faktor Yang Mempengaruhi Belanja Daerah Kabupaten/Kota Provinsi Nusa Tenggara Timur Tahun 2015-2019
Authors: Nasution Ainun Ningsih , Susilowati Dwi
Published: April 2022

This study aims to determine the effect of Regional Taxes, Regional Retribution, Special Allocation Funds, and the amount on District / City Regional Expenditure in East Nusa Tenggara Province for 2015 – 2019. In this study, researchers used a sampling technique whit a sampling method, amounting to 21 districts and one city, using panel data. In this study, the fixed effect method is the best model. The results of this study are local taxes, special allocation funds, and total population have a positive and significant effect on regional spending in East Nusa Tenggara Timur Province. In contrast, local charges positively and significantly affect provincial expenditure on East Nusa Tenggara Province.
Determinan Ketimpangan Distribusi Pendapatan di Karesidenan Malang Tahun 2015-2019
Authors: Ramadhan Yery Arif Ramadhan , Setyo Wahyu Sulistyono
Published: April 2022

This research examines the effect of the total population, minimum wages, and economic growth against income distribution inequality. The object in the study is a residency of Malang. The research used secondary data in 2015-2019 obtained from the Central Bureau of Statistics Republic of Indonesia. The data analysis technique in this research used the panel data regression analysis. The results indicate that total population and minimum wages significantly influence income distribution inequality, while economic growth has no impact on income distribution inequality.
Analisis Tingkat Pendapatan Pedagang Kaki Lima Di Kawasan Wisata Lembah Indah Kecamatan Ngajum Kabupaten Malang
Authors: Yunita Lisa
Published: April 2022

This study aims to determine how much the income of street vendors in Lembah Indah Tourist area, Ngajum District, Malang Regency and How the influence t of capital, length of business, and working hours on the income of street vendors in Lembah Indah Tourist area, Ngajum District, Malang Regency. The data used in this study are primary data obtained using field research sourced from street vendors in the Lembah Indah tourist area as a sample. The data were analyzed using descriptive qualitative and quantitative descriptive analysis methods with data collection techniques through an open questionnaire. The samples taken were all traders, amounting to 25 respondents using census techniques. The analysis tool uses SPSS, including normality test, multicollinearity test, heteroscedasticity test, autocorrelation test, t-test, F test, and determinant coefficient. This study indicates that the variables of initial capital, length of business, and working hours have a significant effect on income.
PERAN UMKM DALAM MENANGGULANGI KEMISKINAN DI PROVINSI JAWA TIMUR
Authors: Anugerah Fajrin Novi , Nuraini Ida
Published: April 2022

This study aims to determine the effect of the number of MSMEs and labors of MSMEs to the poverty of East Java during the period 2017-2018. The variables dependent used in this study is the number of poverty in East Java, while the independent variable are number of MSMEs and labor of MSMEs in East Java This study used panel data regression analysis techniques. The selected model in this study by Chow Test and Hausman Test is fixed effect method (FEM). The data used in this research is secondary data. The results of this study indicate a Prob (F-statistic) value of 0.000000. It can be said that simultaneously the variable number of MSMEs and labor of MSMEs have an effect on poverty of East Java. A value Determinasi Coeficient (R2) is 65.65% Panel data regression calculation results in this study indicate that a variable number of MSMEs with t-Statistics amounted to -7.677828  and probability amounted to 0,0000 means variable number of MSMEs have a negative influence and significant impact on poverty, while the variable labor MSMEs with t-Statistics amounted to -0.971239 and probability amounted to 0,3379 means variable number labor of MSMEs has no effect on poverty. Partially, the variable Number of MSMEs and number labor of MSMEs with F-Probability amounted to 0.000000 so that it can be concluded that the two variables have a positive and significant effect on poverty
Determinan Kemiskinan Di Kabupaten Tuban
Authors: Pradita Agus Hari , Riyanto Wahyu Hidayat
Published: April 2022

The purpose of this research is to know the infulnce Product Domestic Regional Bruto (PDRB) and open unemployment rate on the number of poverty in Tuban Regency the period 2000-2019. The sampel in the study was taken from BPS as much 20 years. The research method used is a quantitative method. The analysis technique used multiple linear regression models with a significant  α 0,05 which was supported by the classical assumption test. The research results prove that PDRB variable has a negative and significant on the number of poverty. While the open unemployment rate variabel has a positive and significant on the number of poverty in Tuban Regency period 2000-2019.
EFEKTIVITAS TENAGA KERJA DAN INVESTASI ASING DALAM PERTUMBUHAN PDB PERKAPITA NEGARA ASEAN
Authors: Saputra Ryandhica Angga , Susilowati Dwi , Arifin Zainal
Published: April 2022

Increase in Gross Domestic Product (GDP) is a major problem that results in any economic development in all countries. Developing countries always have difficulty getting high economic growth, this is because developing countries have not achieved economic stability. Supporting factors, including labor and foreign investment, are factors that greatly affect the country's GDP growth. The samples of Asean countries used include Indonesia, Malaysia, the Philippines, Thailand, Myanmar, Vietnam and Cambodia with vulnerable years from 2000 to 2018. Using data on X1 Labor and X2 Foreign Investment (FDI) and processed using the panel data method on E-views and the results show that foreign labor and investment have a significant effect on GDP per capita growth in Asean countries. It is proven that the increase in foreign investment (FDI) each period will have an impact on labor demand so that the GDP per capita produced by each country will also increase.
ANALISIS DAMPAK EKONOMI PANDEMI COVID-19 TERHADAP PENGRAJIN BATIK DI KECAMATAN KEREK TUBAN
Authors: Wakhidah Laila Murningsih Novrian , Abdullah Muhammad Faisal , Kusuma Hendra
Published: April 2022

The purpose of this study was to see the difference in the economic impact of the condition of the batik craftsmen of Gedog during the Covid-19 pandemic compared to before the Covid-19 in Kerek District, Tuban Regency. The object of this research is the craftsmen of Gedog written batik in Kerek District, with a total of 54 craftsmen. The type of data collected is primary data with a closed questionnaire data collection technique. Data analysis methods include descriptive statistical test, normality test and Wilcoxom test. The results of this study indicate that t there is a difference during the Covid-19 pandemic compared to before the Covid-19 Gedog written batik craftsmen in Kerek District, Tuban Regency. The positive impact of the increase in time before the Covid-19 in Gedog written batik is that the community has achieved independence in improving their economy through new skills in making Gedog batik so that they get a bigger income than before. On the negative side, when there was Covid-19, people felt tired due to a lack of production and marketing due to large-scale restrictions which resulted in reduced income and public interest.
ANALISIS PENGARUH INVESTASI, NET EKSPOR DAN PENGELUARAN PEMERINTAH TERHADAP PERTUMBUHAN EKONOMI INDONESIA
Authors: Pangestin Yahya Yakaria , Soelistyo Aris , Suliswanto Muhammad Sri Wahyudi
Published: April 2022

Broadly, this research aims to find out how free variables affect Investment, Net Exports and Government Spending on Indonesia's Economic Growth. The type of data used is annual data starting from 2000 to 2019. The methods used are Partial Adjustment Model (PAM), Hypothesis Test and Classic Assumption Test. The results of the classic assumption test show that the normality test in this study meets the assumption of normality, the auto correlation test in this study did not have auto correlation and the heteroscedasticity test in this study avoided heteroscedasticity. Investment Variable has a positive effect on Indonesia's economic growth, Net Export variables have an insignificant positive effect on Indonesia's economic growth and Government Expenditure has a positive and significant effect on Indonesia's economic growth. Simultaneously variable Investment, Net Export and Government Expenditure simultaneously affect Indonesia's economic growth with a probability value of 0.0000.
ANALISIS PENGARUH SUKU BUNGA, INFLASI DAN PDB TERHADAP JUMLAH PERMINTAAN KREDIT PERBANKAN DI INDONESIA TAHUN 2009-2019
Authors: Arianti Riski Nur , Abdullah Muhammad Faisal
Published: April 2022

Credit demand has an important role and affects economic growth. The demand for credit can be influenced by various factors, both internal and external. This study aims to see how much influence the macroeconomic factors have on the demand for bank credit in Indonesia. The data used in this research is secondary data in the form of quarterly data for the 2009-2019 period. The results show that simultaneously there is a significant positive effect contributed by the variable rate of inflation, exchange rate, and Gross Domestic Product on banking stock prices in Indonesia with a Prob value. F-statistic 0.0000 <0.05. The partial results show that interest rates have a significant negative effect on banking stock prices, inflation has a negative and insignificant effect on bank credit demand, while Gross Domestic Product has a significant positive effect on bank credit demand in Indonesia
PENGARUH PEMBANGUNAN INFRASTRUKTUR JALAN RAYA DAN LISTRIK TERHADAP PDRB DI KOTA MOJOKERTO
Authors: Prasetya Dhimas Ilham , Nuraini Ida , Kusuma Hendra
Published: April 2022

The purpose of this research is to know the effect of road condition,electricity on PDRB in Mojokerto City. . The method used is a quantitative approach using secondary data obtained from the annual report of BPS of Mojokerto City. The analytical tool used is multiple linear regression. Data was processed through E-views. The results showed that road condition variable and electricity variable have a significant positive effect on PDRB of Mojokerto City. In this study researchers have limitations using only 16 years and using road condition variable and electricity variable as an independent variable so that it can affect theresearch results. The next researcher is expected to beable to develop the number of variables and be able to add observation time.
Pengaruh Harga Minyak Dunia, Inflasi, Konsumsi Rumah Tangga terhadap Pertumbuhan Ekonomi Indonesia
Authors: Almaya Ulin Nuhaella , Rianto Wahyu Hidayat , Hadi Syamsul
Published: April 2022

This study aims to determine the effect of world oil prices, inflation, and household consumption on economic growth in Indonesia. This research is a type of descriptive research with a quantitative approach using the annual time series in 1988-2018. The analysis technique used in this study is multiple linear regressions with 31 samples. The results showed that both simultaneously and partially, world oil prices and inflation had a significant (negative) effect and household consumption had a significant (positive) effect on economic growth. Based on research results, the government can improve and build oil and gas infrastructure so that it can  optimize oil production. This is very useful because it will reduce oil imports and also reduce the inflation rate. The government can also establish monetary policy and fiscal policy to maintain inflation stability. Other policies that can be done are by increasing the amount of goods produced so that the number of goods in circulation increases, setting maximum prices for several types of goods, and also making policies that can control the inflation rate so as to encourage domestic consumption due to price stability, so that consumption expenditure can be increase or can be stable