bluuebunny/crossref_metadata_2025 huggingface dataset:
State marketing in the improvement of pension provision in Ukraine
Authors: Safin O. , Sendetska S.
Published: February 2022

The paper aims to determine the features and justify the need to use state marketing to meet public needs as one of the types of marketing. It has been found out that the main goal of state marketing is to study and form a complex of needs (individual, group, public) and develop eﬀective ways to satisfy them, taking into account real economic opportunities and other limiting factors.
The study reveals the diﬀerence in state marketing and the political and social one. It is indicated that state marketing, along with well-known marketing tools, uses administrative, organizational, regulatory and other levers of inﬂuence.
It has been established that the state represented by the central and local government bodies is the main subject of state marketing. The state can directly participate in meeting needs and (or) create an environment and conditions for their implementation.
Some aspects of state marketing use are considered on the example of meeting the need for material support for people of retirement age. The main components of the set of state marketing in pension provision have been determined.
It has been proven that they are all interconnected and interdependent and require research, further improvement and development.
The key important tasks of the pension reform are considered. The decisive role of the state in pension provision has been proved. It is noted that radical measures are inappropriate to apply in the pension system reforming - it is necessary to predict the social consequences of the decisions taken, since they are often accompanied with active public protests. Therefore, any pension reform must be accompanied by appropriate marketing communications.
The main goal of state marketing in pension provision is determined. It involves the development of a pension system aimed at qualitative satisfaction of individual and collective needs in pension provision, as well as in creating conditions conducive to its eﬀective functioning.
It is indicated that a comprehensive approach is required to reform the pension system along with improving the entire social protection system in the state, economic development stimulation, increase in the level of the population wages and employment.
Key words: needs, state marketing, marketing, pension provision, pension, political marketing, social marketing.
Financing of agricultural enterprises: analysis of long-term trends and structural changes
Authors: Buriak A. , Boiko S. , Demianenko I.
Published: February 2022

The article is devoted to the study of long-term trends in the financing of agricultural enterprises in Ukraine.
It is argued that agriculture is one of the most important types of economic activity for the Ukrainian economy, as together with other related types of economic activity (processing industry, trade) form about half of GDP. In such conditions, an important task of ensuring the sustainable development of agriculture is the financing of agricultural enterprises while respecting the principles of sufficiency and financial stability.
The application of a system of absolute and relative indicators for empirical assessment of financing of agricultural enterprises of Ukraine, as well as technologies of regression analysis, correlation analysis is proposed.
It is established that the financial resources of agricultural enterprises of Ukraine in the study period (2009–2019) increased 7.2 times, which exceeds the growth rate of total financial resources of enterprises in the economy and by type of economic activity (transport, warehousing, postal and chickens). activities, industry, construction, wholesale and retail trade, financial and insurance activities, etc.).
It is argued that the periodization of financing of agricultural enterprises of Ukraine in the long run on the basis of seven features (total financial resources, equity, long-term liabilities, current liabilities, level of financial stability, priorities by size of enterprises and priorities by type agricultural activity).
The empirical assessment of financial support of agricultural enterprises of Ukraine allowed to distinguish three periods: 2010–2013 – toincrease in financial resources of agricultural enterprises of Ukraine with the predominance of equity, ensuring the financial stability of enterprises, violated payment discipline; 2014–2016 – toreduction of financial resources of agricultural enterprises under the condition of predominance of borrowed funds, partial loss of financial stability of enterprises during economic, currency and political instability; 2017–2019 – toincrease in financial resources of agricultural enterprises in the direction of restoring financial potential with the transition of importance to medium and small agricultural enterprises specializing in the cultivation of annual and biennial crops, livestock, ancillary activities in agriculture and post-harvest activities.
Keywords: agriculture, financing of agricultural enterprises, financial resources, equity, loan capital, long-term trends.
The importance role and place of online resources in widespread agroinnovation
Authors: Korinets R. , Bachynskyi R.
Published: February 2022

It has been proven that agricultural micro and small agricultural enterprises are limited in access to the best modern agricultural practices due to the presence of both objective and subjective factors.
The online resource center "Best practices of farmer-farmer practices" aims to provide agricultural MMAE with practical knowledge and demonstration base of modern agricultural technologies in Ukraine and the world, which can be implemented in the fruit and vegetable sector, livestock, aquaculture, poultry (except chickens). confectionery and craft products. Such a resource should become a communication platform, first of all, between those who implement modern approaches and technologies and their potential followers.
Given that the key beneficiaries of the resource center are business entities, the idea of transforming the center into a business entity that provides services to both such entities and authorities, local governments for the successful implementation of agricultural policy is obviously development of rural entrepreneurship.
Thus, the resource center "Best practices of farmer-farmer" will help to solve the problems and challenges not only of producers, distributors and implementers of agricultural innovations, best agricultural practices, but also the executive and local governments.
The services provided through the online platform "Best Agricultural Practices for MMAE " will be able to disseminate innovative technologies that have practical application among small and medium-sized businesses in the field of agribusiness.
Using the online platform as a communicator, it is planned to ensure constant and effective communication between agricultural producers, scientists, educators and advisors.
Creating an information resource on a sectoral basis will allow to concentrate in one place information about the best modern agricultural practices and provide access to them for end users - agricultural producers, using existing channels of information dissemination in the system of agricultural advisory.
Key words: innovation, agricultural enterprise, online platform, advisory, agricultural practice.
Transformation of the tourism industry in the digital economy
Authors: Stryzhak O.
Published: February 2022

The article is devoted to defining the transformations of the tourism industry under the influence of the digitalization of socio-economic relations. The tourism industry is one of those industries that have proven to be the most sensitive to digital transformation. Digital technologies affect all aspects of tourism activities - from designing creating a chain of tourist product- to forming a hotel rating in the digital space. In this context, changes in the concept of tourism activity in the context of the formation of a digital economy require the development of an appropriate scientific and methodological base.
The study determined the existence of a relationship between indicators of the level of digitalization and the state of tourism development in the country. The level of digitalization of the country is proposed to be assessed by the World Digital Competitiveness Ranking (WDCR). An indicator reflecting the state of tourism development in a country is the Travel & Tourism Competitiveness Index (TTCI). The panel sample of the study covers 63 countries in 2019. Based on the analysis, it was concluded that the further development of tourism in the context of the formation of the digital economy is impossible without focusing on the features of the introduction of digital technologies in the tourism industry.
The main directions of digitalization of the tourism industry have been identified, such as the introduction of booking systems for hotel and transport services, the spread of augmented reality technologies, the development of social networks and tourist Internet resources and communication channels, etc., as well as the problems that it causes.
A matrix of SWOT analysis of the development of the tourism sector of Ukraine in the digital economy is proposed. Applying an approach to identifying opportunities and threats, strengths and weaknesses in the development of the domestic tourism sector in the digital economy will allow tourism entities to implement a balanced development strategy.
Key words: tourism, tourism industry, tourism product, digital economy, digitalization, digital technologies.
A Cadaveric Study of Thread Cubital Tunnel Release with Newly Developed Threads
Authors: Kang Minsuk , Nam Yong Seok , Kim In Jong , Park Hae-Yeon , Ham Jung Ryul , Kim Jae Min
Published: February 2022

Objective : The percutaneous thread transection technique is a surgical dissecting method using a dissecting thread inserted through a needle under ultrasound guidance without skin incision. As the new dissecting threads were developed domestically, this cadaver study was conducted to compare the effectiveness and safety between the new threads (ultra V sswire and smartwire-01) and a pre-existing commercial dissecting thread (loop & shear) by demonstrating a modified looped thread cubital tunnel release.Methods : The percutaneous cubital tunnel release procedure was performed on 29 fresh cadaveric upper extremities. The preexisting commercial thread was used in 5 upper extremities. The two newly developed threads were used in 24 upper extremities. Two practitioners performed the procedures separately. After the modified looped thread cubital release, anatomical and histological analyses were performed by a blinded anatomist. The presence of the dissected cubital tunnel and damaged adjacent soft tissue was assessed.Results : Out of the 29 cadaveric upper extremities, 27 specimens showed complete dissection of the Osborne ligament and the proximal fascia of the flexor carpi ulnaris muscle. One specimen was incompletely dissected in each of the ultra V sswire and smartwire-01 groups. There were no injuries of adjacent structures including the ulnar nerve, ulnar artery, medial antebrachial cutaneous nerve, or flexor tendon with either the commercial thread or the newly developed threads. The anatomical analysis revealed clear and sharp incisional margins of the cubital tunnel in the Smartwire-01 and loop & shear groups. All three kinds of threads maintained proper linear elasticity for easy handling during the procedure. The smartwire-01 provided higher visibility in ultrasound than the other threads.Conclusion : The newly developed threads were effective and safe for use in the thread cubital tunnel release procedure.
Obtención de espumas metálicas utilizando como metal principal aluminio comercial y reciclado con diversos agentes espumantes
Authors: Espasandin José Manuel , Canteros Ofelia Jessica Soledad , Barabas Leonardo Gastón , Malachevsky María Teresa
Published: February 2022

Se realizó el presente trabajo basado en la fabricación de espumas metálicas mediante la técnica de pulvimetalurgia. Para la fabricación de muestras, se emplearon polvos de aluminio comercial y reciclado. En algunos experimentos se adicionó cobre en polvo como aleante, tanto comercial como reciclado. Se utilizaron bicarbonato de sodio (NaHCO3) y carbonato de calcio (CaCO3) cómo agentes espumantes. Los polvos se mezclaron en diferentes proporciones. Se sometieron a un prensado con presiones y temperaturas diversas. Se espumaron en el horno a temperaturas de entre 640 ºC y 900 ºC en periodos de tiempos que varían entre 1,5 minutos y 30 minutos. Todos los métodos y procedimientos utilizados permitieron la obtención de espumas, que mediante imágenes fotográficas y/o tomografía de rayos X demuestran cualitativamente diferencias estructurales. Tales como el tipo, forma y distribución de los poros, y aparición de fallas internas (fisuras) normales a la dirección de compactación de la muestra durante el proceso de compresión unidireccional de los polvos en el estado verde.
Electrospray Deposition of Multiwalled Carbon Nanotubes-OH/ Polyvinylidene Fluoride Nanocomposites for Volatile Organic Compounds (VOCs) Detection
Authors: Joaquim Akinwunmi , Paul Omari , Thai Anthony , Jones Aya , Falconer April , Mu Richard , Williams Frances
Published: February 2022

In this work, we report on the synthesis and performance evaluation of electrosprayed multi-walled carbon nanotubes (MWCNTs)/ Polyvinylidene Fluoride (PVDF) nanocomposite materials for gas detection of volatile organic compounds. MWCNTs are characterized by a hollow structure, large surface area and several unique properties that make them potentially excellent for gas sensing. However, in order to improve their sensitivity, stability and reproducibility effects, the carbon nanotubes were doped with PVDF polymer in a minimal concentration such that it utilizes its strong binding effect with interconnected nanotubes and the substrate and further, the polymer does not affect the dominance of MWCNTs on the surface as observed from SEM characterization. The electrospray deposition technique, combined with sonication, was used to ensure the MWCNT was dispersed evenly in the polymer matrix, as MWCNTs tend to aggregate due to their strong Van der Waals forces. The sensing mechanism and the kinetic adsorption of gases on the sensors were studied and the experimental result shows that MWCNT-OH/PVDF sensor revealed a larger sensitivity than that of MWCNT-OH sensor to tested VOCs at room temperature.
Qualidade da assistência e humanização do cuidado à saúde da mulher no período de parto no contexto de São Tomé e Príncipe, África Subsaariana
Authors: Uhatela Wilsa Kaina Managem Fernandes , Schimith Maria Denise , Oliveira Gabriela , Weiller Teresinha Heck
Published: February 2022

Objetivo: refletir sobre a qualidade da assistência e humanização do parto a partir da análise de produções cientificas. Método: trata-se de uma reflexão teórica fundamentada na análise de produções cientificas. A busca foi realizada na base de dado PUBMED e na Biblioteca Virtual em Saúde (BVS) e SCIELO, no período de fevereiro a abril de 2021, mediante a estratégia de busca: “assistência à saúde” AND “qualidade” AND “humanização do parto”. Foram incluídos estudos primários publicados em português, inglês ou espanhol, disponíveis na íntegra, e excluídos estudos que não atenderam ao objetivo do trabalho. A seleção se deu a partir dos títulos, em seguida, a leitura dos resumos e textos na íntegra. Resultados: em relação ao idioma de publicação, quatro estavam disponíveis na língua inglesa, dois em espanhol e oito em português, todos foram publicados entre 2017 a 2020. Quanto ao local da realização do estudo, dois foram realizados na Colômbia, um estudo realizado na Tanzânia, um estudo realizado em Moçambique e dez estudos realizados no Brasil. Quando analisados os temas dos trabalhos, dois artigos abordaram assuntos relacionados ao programa de humanização do parto e nascimento, cinco sobre a humanização do parto e sete sobre a assistência humanizada no período de pré e pós parto. Conclusão: a partir dos resultados discutidos neste artigo, infere-se a necessidade de aprofundar estudos sobre a temática e elaborar estratégias e tecnologias em saúde que ajudarão na promoção da qualidade da assistência ao parto nas instituições de saúde em São Tomé e Príncipe.
Avaliação da atividade antimicrobiana do extrato de Malpighia emarginata frente à Escherichia coli e Sthaphylococcus aureus in vitro
Authors: Silva Guilherme Douglas Freitas , Lima Pedro Henrique da Silva , Silva Antônio Rogério , Freitas Érisson Rubens Araújo , Silva Felipe Sousa da , Gondim Samuel de Lima , Silva Ana Beatriz de Sousa , Rebouças Maria Eduarda Sales , Silva Dinardo Alves da , Souza Filho Jose Ossian Almeida
Published: February 2022

A ação de plantas, seus fenois e bioativos têm sido alvo de intensa investigação científica, constituindo uma importante fonte de novos fármacos para atualidade. O objetivo deste trabalho direcionou-se em avaliar a atividade antimicrobiana interativa, in vitro, dos extratos do cultivo orgânico da acerola, Malphigia emarginata, frente às cepas padrão Staphylococcus aureus CLITS 2275 FIOCRUZ, e Escherichia coli CLIST 3862 FIOCRUZ. Para tanto foram feita análise físico-química. Os resultados revelaram que os extratos testados da acerola em dois estados de maturação, Verde e Madura, apresentaram atividade frente às cepas de S. aureus e E. coli, com halos de inibição médios 9,7 e 9,5 mm para a madura; e 11,15 e 10,67 mm para a verde; comparados com o controle positivo, álcool etílico a 96 %. Atividade antimicrobiana mostrou-se semelhantes, por não apresentarem diferença significativa (p < 0,05). Nas análises físico-química foram utilizados os extratos verde e maduras, junto com seus insumos, entre os extratos o pH ficou entre 4,07 e 5,23; sólidos solúveis 0,80 a 0,92 %, teor de ácido cítrico 1,40 a 1,43 %; em açúcares redutores 2,29 a 8,92 %, em ácido ascórbico (mg/100g) variou entre 2491,30 e 3406,34. De modo que, o uso dos extratos desse estudo merece um olhar muito cuidadoso pela possibilidade de atuação diretiva abrindo margem tanto pela análise das cepas, quanto os dados obtidos no físico-químico assim sendo um possível meio para elaboração de fármacos.
Uso do Remdesivir no tratamento da Covid-19: uma revisão integrativa
Authors: Malacrida Gabrielly Alves , Santos Gabriel Henrique Maximino , Pereira Valéria Cataneli , Keller Rogéria
Published: February 2022

O presente estudo teve por objetivo determinar a eficácia, efetividade e segurança do Remdesivir no tratamento para a Covid-19 através de uma revisão integrativa. A busca dos artigos foi realizada em março de 2021 nas bases de dados Pubmed, Scielo, Embase e Cochrane. Para guiar essa pesquisa, levantou-se a questão norteadora: “Qual o papel do Remdesivir no tratamento da Covid-19 em humanos?”. Foram utilizados os descritores “Covid ou Sars-Cov-2 ou Coronavirus” e “treatment” e “Remdesivir”. Os critérios de inclusão foram estudos primários originais que abordassem o tema proposto, disponíveis na integra, entre 2019-2021, nos idiomas português ou inglês. Dos 3012 artigos encontrados, foram utilizados 17 que atenderam os critérios de inclusão. A maioria dos estudos encontrados relatou uma melhora no quadro dos pacientes tratados com Remdesivir, porém é importante ressaltar que a terapia com o medicamento também apresentou diversos efeitos colaterais e não alterou o índice de mortalidade. Com base nos dados analisados, o Remdesivir demonstrou resultados promissores, sugerindo um perfil de risco-benefício favorável, porém até onde se foi observado, a tava de óbitos não foi alterada e seu uso prolongado pode desencadear efeitos colaterais indesejáveis.
Diversidade e Formação Humana Integral: uma relação convergente
Authors: Silva Leonardo Bezerra da , Sousa Antonia de Abreu
Published: February 2022

O propósito central deste artigo é investigar quais os aspectos gerais estão relacionados à educação na (e para) a diversidade e como essas questões se relacionam e convergem com as postulações de uma Formação Humana Integral, tendo como contexto a Educação Profissional e Tecnológica (EPT). Ao demonstrarmos essas convergências propomo-nos a responder a seguinte indagação: Seria, de fato, o estudo da diversidade uma questão preponderante para o processo de formação humana em sua integralidade? Para tanto, foi realizada uma análise bibliográfica acerca da temática, com enfoque nos conceitos e contextualizações da diversidade, identidade e diferença, destacando como essas concepções estão permeadas pelas relações de poder existentes na sociedade e influem em suas construções sociais. Como direcionamento argumentativo, o artigo destaca alguns aspectos relacionados às diversidades de gênero, étnico-racial e sexual. Ao final da pesquisa foi possível reconhecer a real convergência entre o estudo histórico crítico da diversidade com as concepções da Formação Humana Integral, uma vez que a diversidade se encontra no escopo das relações sociais onde a vida é produzida, sendo que é justamente a análise crítica da totalidade das relações sociais um dos compromissos da Formação Humana Integral. Ademais, ao oferecer um estudo aprofundado das questões inerentes à diversidade, é possível compreender a gênese histórica de fenômenos como o racismo, o machismo e a homofobia e vislumbrar alternativas para a construção de uma sociedade mais justa e igualitária.
Desafios da adesão ao tratamento terapêutico do programa Hiperdia na Estratégia Saúde da Família: o médico de família como educador
Authors: Cirino Flaviano da Costa , Cirino Geruza Sales Galdino , Fassarella Michel Barros , Galdino Gabriel Antônio Sales , Ribeiro Wanderson Alves , Neves Keila do Carmo , Fassarella Bruna Porath Azevedo
Published: February 2022

Trata-se de uma pesquisa bibliográfica de abordagem qualitativa e caráter descritivo que tem como objeto de estudo adesão ao tratamento terapêutico no programa Hiperdia, que objetivou descrever as contribuições do médico de família no processo de adesão ao tratamento terapêutico do programa Hiperdia na Estratégia Saúde da Família. Como metodologia, utilizou-se a Biblioteca Virtual de Saúde, nas bases de informações LILACS, BDENF, MEDLINE e SCIELO, com recorte temporal de 2015 a 2019. O programa da Hiperdia se constitui como uma estratégia: De acompanhamento de usuários hipertensos e/ou diabéticos, com as funções de vincular o paciente à Unidade Básica de Saúde e à Equipe de Saúde da Família Fazem parte da proposta do programa estabelecer vínculos entre usuários e equipe e considerando sua realidade social, convergindo com a perspectiva de um cuidado mais integrador, e voltado para uma dimensão mais holística do ser. A relação médico-paciente é de grande relevância para adesão tratamento. O vínculo presume uma relação de compreensão, apoio, escuta e estímulo à narração. Sendo assim, estimula uma relação horizontal, de confiança, com liberdade para o paciente tirar suas dúvidas. Conclui-se ainda, que as orientações do médico de família são necessárias no que se refere ao tratamento medicamentoso e não medicamentoso. Diante disso, além das recomendações sobre mudanças na alimentação e diminuição do sedentarismo, no tratamento do Diabetes e da Hipertensão Arterial, orientam-se os pacientes sobre a necessidade de modificações no estilo de vida e a grande relevância do suporte familiar, como grupo de apoio.
Pemanfaatan Limbah Ikan Sidat (Anguilla marmorata) Untuk Meningkatkan Pertumbuhan Ikan Lele (Clarias sp.)
Authors: Murtini Sri , Neksidin Neksidin , Fekri Latifa , Adimu Hasan Eldin
Published: February 2022

Tujuan penelitian ini adalah untuk mengkaji nutrisi yang terdapat pada limbah ikan sidat (Anguilla marmorata) yang dapat dimanfaatkan ikan lele (Clarias sp.) sebagai pakan tambahan. Penelitian ini menggunakan rancangan acak lengkap yang terdiri dari 2 perlakuan dengan masing-masing 3 ulangan. Pemeliharaan dilakukan selama 30 hari. Jumlah ikan yang ditebar adalah 5 ekor/akuarium. Akuarium yang digunakan berukuran 30x40x50cm. Perlakuan A: pemeliharaan ikan lele dengan pakan komersil 3% dari biomassa, perlakuan B: pemeliharaan lele dengan pakan komersil 1% dari biomassa ditambahkan limbah sidat cair 3 liter/3 hari. Hasil pengujian kandungan nutrisi pada limbah sidat cair memiliki nilai protein sebesar 4% dengan kandungan amoniak sebesar 0,037 mg/L. Nilai SR ikan lele pada masing-masing perlakuan adalah 100%. Laju pertumbuhan spesifik pada perlakuan A sebesar 2,31% sedangkan pada perlakuan B sebesar 1,63%.  Biomassa ikan lele pada perlakuan A mengalami peningkatan sebesar 100% sementara perlakuan B biomassa ikan lele meningkat 65%. Namun berdasarkan hasil analisis statistik menunjukkan bahwa tidak ada perbedaan nyata antar perlakuan (p>0,05) baik itu pada pengujian sintasan, laju pertumbuhan spesifik maupun konversi pakan. Hal ini menunjukkan bahwa pemanfaatan limbah ikan sidat dapat mendukung peningkatan pertumbuhan ikan lele.Kata kunci: ikan lele, limbah pemeliharaan  ikan sidat, pakan.
PENGARUH KOMPETENSI PERSONIL, KEPRIBADIAN DAN TEAM WORK TERHADAP KUALITAS LAYANAN DI POLRES MUNA
Authors: Mane Firmansyah , Madjid Rahmat , Aliddin Laode Asfahyadin
Published: February 2022

This study aims to determine the effect of personnel competence, personality, and team work on the quality of service at the Muna Police. This research approach is a survey with an explanatory research design. Data was collected in a cross section by using an instrument in the form of a questionnaire or questionnaire. The population of this study were all members of the National Police at the Muna Police Station, Southeast Sulawesi Province. The size of the research sample was 82 people using a random technique based on strata (stratified proportional random sampling). Data analysis with descriptive analysis and Multiple Linear RegressionThe results showed that competence, personality, and team work had a positive and significant effect either simultaneously or partially on service quality. Thus it can be said that changes in competence improvement are reflected through improvements, skills and attitudes; personality reflected through interpersonal relationships, friendliness, conscientiousness, emotional stability and openness to experience, as well as teamwork reflected through high participation, open communication, listening to members well, sharing leadership, and self-assessment have positive and significant contributions in supporting improvement of service quality at the Muna Resort Police..
COVID-19: DAMPAK TERHADAP HARGA SAHAM SYARIAH DI ASEAN
Authors: Bintari Vivi Indah , Kusnandar Deasy Lestary
Published: February 2022

The purpose of this study was to examine the differences in Sharia stock prices before and after the announcement of the first case of COVID-19 in ASEAN. The population in this study were all countries that are members of ASEAN using purposive sampling method so that a sample of 3 countries was obtained, namely Indonesia (JII), Malaysia (FTSE HIJRAH) and Thailand (SETS). The method used in this research is an event study using paired sample t-test. Based on the test results, it is known that there are significant differences in the stock index JII ,FTSE HIJRAH, SETS before and after the announcement of the first case COVID-19 case in ASEAN.
Segementasi Potential Entrepeneur Dan Aspek-Aspek Mempengaruhinya Di Indonesia: Pemanfaatan Data Global Entrepreneurship Monitor
Authors: Lubis Deltha Airuzsh
Published: February 2022

Entrepreneurial activity is considered as one of the solutions in reducing the unemployment rate because it can absorb labor and encourage national economic development. Several Asian countries have experienced economic changes over the last three decades which were marked by an increase in the number of business activities and business output with the direction of achievement in line with the pace of economic growth. Meanwhile, novice business actors at the national level are still relatively low. Based on this, it is interesting to explore the segmentation of potential entrepreneurs and startups and the aspects that influence it by utilizing GEM data. The results showed that with the Chi-Squared Automatic Interaction Detection (CHAID) method, people living on the island of Java with an age range of 35-44 years with the status of working at home, or working full time or part time, are likely to become potential entrepreneurs around 59.7%. The results of the logistic regression show that internal factors (career choice, business skills and knowledge, and fear of failure in entrepreneurship), and external factors (people around who are also entrepreneurs, the first opportunity to start a business, media showing business success stories, and respectable social status of business people) affects the increase in potential entrepreneurs.
ABOUT MODERN POSSIBILITIES OF REUSING ROAD-BUILDING MATERIALS WHEN REPAIRING ROAD PAVEMENTS OF AN IMPROVED LIGHTWEIGHT TYPE
Authors: Holovko Serhiy
Published: February 2022

At present, when developing design solutions for the repair of non-rigid road pavements of an improved lightweight type, they provide for the device of a base layer using cold recycling technology or from a crushed stone-sand mixture treated with a mineral or complex binder, and two layers of asphalt concrete are laid on top. Based on the results of exploratory studies aimed at wider reuse of road building materials, it is proposed, when repairing a road surface of an improved lightweight type, instead of the top layer of a base made of asphalt concrete, arrange a layer of road material made by the technology of cold recycling ” in the mixer” using an organic binder, and the bottom layer of the base should be made of road material made by the technology of cold recycling “on the road” using a mineral or complex binder. Considering that Ukraine has insufficient experience in preparing mixtures using cold recycling technology using foamed bitumen or bitumen emulsion, the features of their manufacture are given. After milling the asphalt concrete, the bottom layer of the base is reinforced from the road material made using the cold recycling technology “on the road” using a mineral or complex binder. Layers of materials arranged according to the technology of cold recycling, due to processing with a small amount of binders, have insufficient resistance to the action of the wheels of vehicles, and therefore, on top of these layers, it is necessary to arrange a coating layer of materials that provide resistance to dynamic action. The given approach allows to obtain a reduction in the cost of pavement repair due to a decrease in energy consumption for the preparation of asphalt concrete, since the production of materials using cold recycling technologies does not provide for heating the material.
ANALYSIS, FEASIBILITY AND POSSIBILITY OF USING MODERN EQUIPMENT FOR TESTING OF ROAD MARKING MATERIALS IN ACCORDANCE WITH THE EUROPEAN STANDARDS
Authors: Hostev Yuriy , Kostrulova Tetyana
Published: February 2022

The current stage of the road sector development is characterized by the increased demand in the road marking. For the arrangement of road marking, various materials are used: paint, retroreflective glass beads, plastics of cold and hot application, polymer strips, prefabricated items, etc. Each material has its own set of unique characteristics related to durability, retroreflectivity, cost of application and life cycle. Due to the expansion of the production range of road marking materials, their choice becomes a difficult task and it should be carried out while taking into account the following requirements: normative distances of visibility must be ensured in all weather conditions 24 hours a day; long-term preservation (resistance to environmental impacts); road marking must not interfere with the vehicles movement, it should foster gliding. In order to properly select the road marking materials, the road traffic level and the predicted operation life cycle should be taken into account. For optimal selection, it is primarily necessary to review the quality characteristics of the materials through the testing of their physical, mechanical, technological and functional characteristics. Commonly, the roads owners require the quality requirements for the materials in accordance with the European standards. Technical requirements for road marking materials and methods of their testing which are lacking in the Ukrainian standards are considered. A list of equipment for the required tests according to the European standards is given. Basing on the analysis results, it can be noted that in order to ensure the compliance of the Ukrainian laboratories abilities to check the quality of technical characteristics of materials according to the European standards, the new equipment should be provided (Tregers device, Stormer viscometer, X-ray fluorescence analyzer, wear test bench and others) as well as mastering the new testing methods. Due to the high cost of the devices and equipment (for example, of the wear test bench), it is necessary to build the test sites on the roads or establish contacts with the European laboratories on the possibility of transferring the samples of materials to them for testing.
Xenon-Enhanced Dynamic Dual-Energy CT Is Able to Quantify Sinus Ventilation Using Laminar and Pulsating Air-/Gas Flow Before and After Surgery: A Pilot Study in a Cadaver Model
Authors: Becker Sven , Huppertz Tilman , Möller Winfried , Havel Miriam , Schuster Maria , Becker Anne Merle , Sailer Martin , Schuschnig Uwe , Johnson Thorsten R.
Published: February 2022

Background

Chronic rhinosinusitis is a common disease with a significant impact on the quality of life. Topical drug delivery to the paranasal sinuses is not efficient to prevent sinus surgery or expensive biologic treatment in a lot of cases as the affected mucosa is not reached. More efficient approaches for topical drug delivery are, therefore, necessary. In the current study, dual-energy CT (DECT) imaging was used to examine sinus ventilation before and after sinus surgery using a pulsating xenon gas ventilator in a cadaver head.

Methods

Xenon gas was administered to the nasal cavity of a cadaver head with a laminar flow of 7 L/min and with pulsating xenon-flow (45 Hz frequency, 25 mbar amplitude). Nasal cavity and paranasal sinuses were imaged by DECT. This procedure was repeated after functional endoscopic sinus surgery (FESS). Based on the enhancement levels in the different sinuses, regional xenon concentrations were calculated.

Results

Xenon-related enhancement could not be detected in most of the sinuses during laminar gas flow. By superimposing laminar flow with pulsation, DECT imaging revealed a xenon wash-in and wash-out in the sinuses. After FESS, xenon enhancement was immediately seen in all sinuses and reached higher concentrations than before surgery.

Conclusion

Xenon-enhanced DECT can be used to visualize and quantify sinus ventilation. Pulsating air-/gas flow was superior to laminar flow for the administration of xenon to the paranasal sinuses. FESS leads to successful ventilation of all paranasal sinuses.
CFTR Modulators Restore Acidification of Autophago-Lysosomes and Bacterial Clearance in Cystic Fibrosis Macrophages
Authors: Badr Asmaa , Eltobgy Mostafa , Krause Kathrin , Hamilton Kaitlin , Estfanous Shady , Daily Kylene P. , Abu Khweek Arwa , Hegazi Ahmad , Anne Midhun N. K. , Carafice Cierra , Robledo-Avila Frank , Saqr Youssra , Zhang Xiaoli , Bonfield Tracey L. , Gavrilin Mikhail A. , Partida-Sanchez Santiago , Seveau Stephanie , Cormet-Boyaka Estelle , Amer Amal O.
Published: February 2022

Cystic fibrosis (CF) human and mouse macrophages are defective in their ability to clear bacteria such as Burkholderia cenocepacia. The autophagy process in CF (F508del) macrophages is halted, and the underlying mechanism remains unclear. Furthermore, the role of CFTR in maintaining the acidification of endosomal and lysosomal compartments in CF cells has been a subject of debate. Using 3D reconstruction of z-stack confocal images, we show that CFTR is recruited to LC3-labeled autophagosomes harboring B. cenocepacia. Using several complementary approaches, we report that CF macrophages display defective lysosomal acidification and degradative function for cargos destined to autophagosomes, whereas non-autophagosomal cargos are effectively degraded within acidic compartments. Notably, treatment of CF macrophages with CFTR modulators (tezacaftor/ivacaftor) improved the autophagy flux, lysosomal acidification and function, and bacterial clearance. In addition, CFTR modulators improved CFTR function as demonstrated by patch-clamp. In conclusion, CFTR regulates the acidification of a specific subset of lysosomes that specifically fuse with autophagosomes. Therefore, our study describes a new biological location and function for CFTR in autophago-lysosomes and clarifies the long-standing discrepancies in the field.
Postoperative Serum Creatinine Serves as a Prognostic Predictor of Cardiac Surgery Patients
Authors: Hou Jian , Shang Liqun , Huang Suiqing , Ao Yuanhan , Yao Jianping , Wu Zhongkai
Published: February 2022

Background

Serum creatinine, an important diagnostic indicator for acute kidney injury (AKI), was considered to be a risk factor for cardiovascular disease. This study aimed to investigate the significance of postoperative serum creatinine in predicting the prognosis of cardiac surgery patients.

Methods

The Medical Information Mart for Intensive Care III (MIMIC-III) database was used to extract the clinical data. Adult (≥18 years) cardiac surgery patients in the database were enrolled. The correlation of postoperative serum creatinine with lengths of intensive care unit (ICU) stay was analyzed with Spearman correlation, and the association of postoperative serum creatinine with hospital mortality was analyzed with chi-square tests. Multivariable logistic regression was used to identify postoperative serum creatinine as an independent prognostic factor for hospital mortality.

Results

A total of 6,001 patients were enrolled in our study, among whom, 108 patients (1.8%) died in the hospital. Non-survivors had much higher postoperative serum creatinine levels (initial: 0.8 vs. 1.2 mg/dl, P < 0.001; maximum: 1.1 vs. 2.8 mg/dl, P < 0.001; minimum: 0.8 vs.1.1 mg/dl, P < 0.001). Positive correlations were observed between postoperative serum creatinine (P < 0.001) and lengths of ICU stay. For all models, postoperative initial creatinine, postoperative maximum creatinine, and postoperative minimum creatinine were all positively associated with hospital mortality (all P < 0.001). The predictive performance of postoperative serum creatinine was moderately good (area under the curve (AUC) for initial creatinine = 0.7583; AUC for maximum creatinine = 0.8413; AUC for minimum creatinine = 0.7063).

Conclusions

This study demonstrated the potential to use postcardiac surgery serum creatinine as an outcome indicator.
A Comparative Study of the Clinical Benefits of Rivaroxaban and Warfarin in Patients With Non-valvular Atrial Fibrillation With High Bleeding Risk
Authors: Liu Peng-Hui , Liu Ze-Hua , Niu Ming-Hui , Chen Ping , Shi Yuan-Bin , He Fei , Guo Rong
Published: February 2022

Objective

To compare the clinical benefits of rivaroxaban and warfarin in patients with non-valvular atrial fibrillation (NVAF) with high bleeding risk.

Methods

A retrospective study was conducted on patients with high bleeding risk NVAF who were hospitalized at the First Affiliated Hospital of Zhengzhou University between May 31, 2016 and May 31, 2019 and took at least rivaroxaban and warfarin. The clinical benefits of both drugs were assessed by efficacy benefit and safety risk. The primary efficacy benefit was a composite end point for stroke (both ischemic and hemorrhagic) and systemic embolism. The secondary efficacy end points were death and myocardial infarction (MI). The principal safety end point was the composite end point of fatal bleeding and critical organ bleeding.

Results

A total of 1,246 patients with high bleeding risk were enrolled, including 787 patients in the rivaroxaban group and 459 patients in the warfarin group. Results of the primary efficacy benefit endpoint were obtained from 104 patients (13.2%) in the rivaroxaban group and 88 (19.2%) patients in the warfarin group (hazard ratio [HR]: 0.681; 95% confidence interval [CI]: 0.512–0.906; P < 0.001 for non-inferiority). The principal safety end points were observed in 49 (6.23%) patients in the rivaroxaban group and in 55 (11.98%) patients in the warfarin group (HR: 0.469 in the rivaroxaban group; 95% CI: 0.314–0.702; P < 0.001). With respect to secondary efficacy and benefit endpoints, 28 (3.56%) patients in the rivaroxaban group and 22 (4.79%) patients in the warfarin group died, with an HR of 0.760 (95% CI: 0.435–1.329; P = 0.336); 32 (4.07%) patients in the rivaroxaban group; and 26 (5.66%) patients in the warfarin group had MI, with an HR of 1.940 (95% CI: 0.495–1.069, P = 0.254) in the rivaroxaban group.

Conclusions

Rivaroxaban is non-inferior to warfarin in the prevention of stroke and systemic embolism in patients with high blood NVAF. Rivaroxaban is superior to warfarin in reducing fatal bleeding and bleeding in critical organs.

Clinical Trial Registration

Chinese Clinical Trials Registry, identifier ChiCTR2100052454.
Gestational Diabetes Mellitus and Preeclampsia: Correlation and Influencing Factors
Authors: Yang Ying , Wu Na
Published: February 2022

Gestational diabetes mellitus (GDM) and preeclampsia (PE) are common pregnancy complications with similar risk factors and pathophysiological changes. Evidence from previous studies suggests that the incidence of PE is significantly increased in women with GDM, but whether GDM is independently related to the occurrence of PE has remained controversial. GDM complicated by PE further increases perinatal adverse events with greater impact on the future maternal and offspring health. Identify factors associated with PE in women with GDM women, specifically those that are controllable, is important for improving pregnancy outcomes. This paper provides the findings of a review on the correlation between GDM and PE, factors associated with PE in women with GDM, possible mechanisms, and predictive markers. Most studies concluded that GDM is independently associated with PE in singleton pregnancy, and optimizing the treatment and management of GDM can reduce the incidence of PE, which is very helpful to improve pregnancy outcomes.
Effects of SGLT-2 Inhibitors on Vascular Endothelial Function and Arterial Stiffness in Subjects With Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Wei Ran , Wang Weihao , Pan Qi , Guo Lixin
Published: February 2022

Objective

This systematic review and meta-analysis aimed to evaluate the effects of SGLT-2 inhibitors (SGLT-2i) on endothelial function and arteriosclerosis in diabetic patients.

Methods

Randomized controlled trials (RCTs) were retrieved from PubMed, Embase, Cochrane Library, and Web of Science databases to evaluate the effects of SGLT-2i on endothelial function and atherosclerosis in type 2 diabetic patients.

Results

We selected 9 RCTs and 2 cohort studys involving 868 patients. Of these, six studies provided flow-mediated dilation (FMD) levels before and after the intervention. The pooled analysis showed that SGLT-2i could significantly improve the FMD compared to the control group (SMD: 0.18, 95% CI: 0.02 ~ 0.34, P = 0.03). Three studies provided the change in FMD before and after the intervention. Pooled analysis showed no significant differences in FMD change between the SGLT-2i group and the control group. (MD: 2.1, 95%-CI: -0.11~4.31, P = 0.06). Five studies showed pulse wave velocity (PWV) results. Pooled analysis showed no significant differences in the change in PWV between the SGLT-2i group and the control group (SMD: 0.11, 95%-CI: − 0.15 ~ 0.37, P = 0.4).

Conclusions

The ability of SGLT-2 inhibitors to improve FMD was significant, but there was no significant effect on PWV levels. SGLT-2i was superior to other antidiabetic agents in improving arterial endothelial function.
A Comparison Study of Multi-Objective Bonobo Optimizers for Optimal Integration of Distributed Generation in Distribution Systems
Authors: Eid Ahmad , Kamel Salah , Hassan Mohamed H. , Khan Baseem
Published: February 2022

In this paper, the three newly published Multi-Objective Bonobo Optimizer (MOBO) variants are assessed and evaluated using statistical analysis for solving the multi-objective optimization of Distributed Generation (DG) into distribution systems. The main objectives of the study are to minimize system loss and enhance voltage profile. While the first variant, MOBO1, depends on the sort and grid-index approach, the second variant, MOBO2, relies on the Non-dominated Sorting Genetic Algorithm-II (NSGA-II) algorithm technique. The last variant, MOBO3, is inspired by the Multi-objective Evolutionary Algorithm based on Decomposition (MOEA/D). The three MOBO algorithms are compared to themselves and to other algorithms solving the same optimization problem. These algorithms include the MOJAYA, Multi-Objective Artificial Ecosystem-Based Algorithm (MOAEO), Multi-Objective Gravitational Search Algorithm (MOGSA), and Multi-Objective Particle Swarm Optimization (MOPSO). The 33-bus and 85-bus radial distribution systems are used test systems for solving the optimal allocation of single- and three-DG units operating at unity power factor. In order to find the best compromise solution, the Pareto Optimal front method is adopted with the help of a fuzzy-based function. The obtained results show the effectiveness of the MOBO variants compared with other algorithms in terms of different statistical parameters and multi-objective performance metrics such as diversity, hypervolume, spacing, and set coverage. While the MOBO algorithm reduces power loss and TVD by 39.59 and 68.31% for a single DG, they are reduced to 58.13 and 88.44% for three DG units allocated to the 33-bus distribution system, respectively. On the other hand, the MOBO algorithm reduces power loss and TVD by 37.28 and 66.84% for a single DG, respectively, they are decreased to 46.35 and 82.53% for three DG units assigned to the 85-bus distribution system. Among the three MOBO variants, it is found that the MOBO1 is superior for a single-DG allocation, while the MOBO3 is the best for the allocation of three-DG units.
Influence of the Casing Eccentricity on the Cement Sheath Sealing Integrity in the Tie-Back Interval Under the Complex Temperature and Pressure Conditions of Deep-Water Oil and Gas Wells
Authors: Li Zhong , Wu Yi , Xie Renjun , Wu Zhiqiang
Published: February 2022

The integrity of cement sheath seals in casing connection sections is an important part of preventing air channelization. It is of great significance to evaluate the failure mechanism of cement sheath seals in casing connection sections under complex temperatures, pressures, and casing eccentricities. Based on the self-developed high-temperature and high-pressure full-size casing connection period of the cement sheath seal integrity evaluation device and the casing loading/unloading casing eccentricity influence on the cement sheath seal failure under the experimental conditions, it is concluded that the casing pressure changes, annulus preset pressure, and casing eccentricity influence the law of cement sheath seal integrity. The results show that the following: ① Casing eccentricity has an important influence on the failure of the cement sheath seal when the casing is loaded, and to ensure the integrity of the cement sheath seal the casing should be greater than 75%; ② in the case that the annular pressure is not set, casing eccentricity has little influence on the integrity of the cement annular seal during casing unloading, and sealing failure occurs when pressure unloading is 15–20 MPa; ③ when there is a preset pressure in the annulus, casing eccentricity has a great influence on seal failure during unloading. The greater the preset pressure in the annulus is, the better the seal integrity of the cement annulus. The research results provide an important basis for ensuring the integrity of cement sheath seals in casing connection sections.