bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of polymorphisms of renin angiotensin system and endothelial nitric oxide synthase genes with premature cardiovascular disease in an Iranian population
Authors: Poorzand Hoorak , Fazeli Bahareh , Khajavi Omid , Gholoobi Arash , Keihanian Faeze , Morovatdar Negar
Published: September 2022

Introduction: The study on polymorphisms and their relationship with diseases is very important for risk assessment. The aim of this study was to determine the relationship between early risk of coronary artery disease(CAD) with renin angiotensin(RAS) genes and endothelial nitric oxide synthase(eNOS) gene in a sample of the Iranian population.
Methods & Materials: In this cross-sectional study, 63 patients with premature CAD and 72 healthy samples were enrolled. Polymorphism of the promotor region of eNOS- and ACE-I/D(Angiotensin Converting Enzyme-I/D) polymorphism were evaluated. Polymerase chain reaction(PCR) test and PCR-RFLP(Restriction Fragment Length Polymorphism) was performed for ACE and eNOS-786 gene, respectively.
Results: The frequency of deletion(D) for ACE gene was 96% for patients and 61% for healthy controls and was significantly higher in patients(P<0.001). Conversely, the number of defective C allele for eNOS gene was similar in both groups(p>0.9).
Conclusion: ACE polymorphism seems to be an independent risk factor for premature CAD.
A tradeoff between enterovirus A71 particle stability and cell entry
Authors: Catching Adam , Yeh Ming Te , Bianco Simone , Capponi Sara , Andino Raul
Published: September 2022

A central role of viral capsids is to protect the viral genome from the harsh extracellular environment while facilitating initiation of infection when the virus encounters a target cell. Viruses are thought to have evolved an optimal equilibrium between particle stability and efficiency of cell entry. In this study, we genetically perturbed this equilibrium in a non-enveloped virus, enterovirus A71 to determine its structural basis. We isolated a single-point mutation variant with increased particle thermotolerance and decreased efficiency of cell entry. Using cryo-electron microscopy and molecular dynamics simulations, we determined that the thermostable native particles have acquired an expanded conformation that results in a significant increase in protein dynamics. Examining the uncoating intermediate states of the thermostable variant suggests a pathway, where the lipid pocket factor is released first, followed by internal VP4 and finally the viral RNA.
A New enhanced Fuzzy Support Vector Machine with Pinball Loss
Authors: Verma Ram Nayan , Srivast Rakesh , Subbarao Naidu , Singh Gajendra Pratap
Published: September 2022

The fuzzy support vector machine (FSVM) assigns each sample a fuzzy membership value based on its relevance, making it less sensitive to noise or outliers in the data. Although FSVM has had some success in avoiding the negative effects of noise, it uses hinge loss, which maximizes the shortest distance between two classes and is ineffective in dealing with feature noise near the decision boundary. Furthermore, whereas FSVM concentrates on misclassification errors, it neglects to consider the critical within-class scatter minimization. We present a Fuzzy support vector machine with pinball loss (FPin-SVM), which is a fuzzy extension of a reformulation of a recently proposed support vector machine with pinball loss (Pin-SVM) with several significant improvements, to improve the performance of FSVM. First, because we used the squared L2- norm of errors variables instead of the L1 norm, our FPin-SVM is a strongly convex minimization problem; second, to speed up the training procedure, solutions of the proposed FPin-SVM, as an unconstrained minimization problem, are obtained using the functional iterative and Newton methods. Third, it is proposed to solve the minimization problem directly in primal. Unlike FSVM and Pin-SVM, our FPin-SVM does not require a toolbox for optimization. We dig deeper into the features of FPin-SVM, such as noise insensitivity and within-class scatter minimization. We conducted experiments on synthetic and real-world datasets with various sounds to validate the usefulness of the suggested approach. Compared to the SVM, FSVM, and Pin-SVM, the presented approaches demonstrate equivalent or superior generalization performance in less training time.
Effects of controlled-release fertilizer on N2O emissions in wheat under elevated CO2 and temperature
Authors: Liu Qi , Liu Yajing , Hao Xingyu , Song Chunxu , Zong Yuzheng , Zhang Dongsheng , Shi Xinrui , Li Ping
Published: September 2022

[Aims] N2O emitted by agricultural ecosystems has a great impact on global warming and climate change. The use of controlled-release fertilizers (CRF) can reduce greenhouse gas emissions. However, the general patterns and variability of nitrogen functional genes in response to CRF associated with N2O emission have not been synthesized under climate change.
[Methods] We investigated the effects of elevated CO2 concentration (EC), elevated temperature (ET), and their combination (ECET) on enzyme activities and gene abundances.
[Results] We found that the cumulative N2O emissions was in the range of 0.39–1.65 kg·ha−1 in the wheat-growing season, accounting for 0.54%–2.29% of the total nitrogen input. EC remarkably reduced the cumulative N2O emissions. The greenhouse gas emissions under ECET were less than the sum of the individual effects. ECET had no synergistic effect with or without CRF. N2O emissions were considerably positively correlated with ammonia-oxidizing bacteria (AOB) at elongation stage. CRF can reduce N2O emissions by reducing enzyme activities. Decreased gene abundances of ammonia-oxidizing archaea, AOB, nirS, and nosZ at the elongation stage and increased ratio of N2O production to reduction at the two stages were observed when compared ET+CRF with ET. CRF can reduce N2O emissions under climate change, especially under EC alone or ET alone. CRF and EC remarkably reduced the global warming potential.
[Conclusions] The results of our study enable the establishment of effective mitigation measures for N2O emissions under future climate scenarios.
Mistreatment of women during childbirth and its influencing factors in maternity hospitals in Tehran, Iran: a formative qualitative multi-stakeholder study
Authors: Mirzania Marjan , Shakibazadeh Elham , Bohren Meghan A. , Hantoushzadeh Sedigheh , Babaey Farah , Khajavi Abdoljavad , Foroushani Abbas Rahimi
Published: September 2022

Background
Mistreatment during labour and childbirth is a common experience for many women around the world. A picture of the nature and types of mistreatment; and especially its influencing factors has not yet been identified in Iran. This study aimed to explore the manifestations of mistreatment and its influencing factors in maternity hospitals in Tehran.
Methods
A formative qualitative study was conducted using in-depth face-to-face interviews between October 2021 and May 2022 in five public hospitals. Participants included women, maternity healthcare providers, and managers at hospital and Ministry of Health levels. Participants were selected using purposive sampling. Recorded interviews were transcribed verbatim and thematically analyzed with a combined deductive and inductive approach using MAXQDA 18.
Results
A total of 60 interviews were conducted. Women experienced various forms of mistreatment during labour and childbirth, including verbal abuse, frequent and painful vaginal examinations, neglect and abandonment, lack of supportive care, denial of mobility and pain relief, and physical abuse. Four main themes were identified as the drivers of mistreatment: (1) individual-level factors (healthcare providers perception about women’s limited knowledge on childbirth process, untrained companions, mismatched expectations of women for care, and discrimination based on ethnicity or low socioeconomic status); (2) healthcare provider-level factors (healthcare provider stress/stressful working conditions, healthcare providers with limited personal experience of pregnancy and childbirth, neglect of midwives' identities by doctors, poor educational contents and curriculum, and low salary and lack of incentive); (3) hospital-level factors (lack of staff, lack of supervision and control, type of hospital, inadequate physical structures); and (4) national health system-level factors (lack of access to pain management during labour and childbirth and perceptions about forced vaginal birth in public hospitals).
Conclusions
There are multiple level drivers for mistreatment which requires multifaceted interventions. These interventions should emphasize training of pregnant women and their companions, training healthcare providers, encouraging and managing work shifts, strengthening the position of midwives in public hospitals. Moreover, continuous monitoring of the performance of providers, increase staff numbers and improvement of physical space of the maternity wards, as well as implementation of the related guidelines, including painless childbirth, should also be considered.
Renal Toxicity Caused by Diethylene Glycol: an Overview
Authors: Araujo Stanley Almeida , Faria Barbara Caroline Dias , Vasconcelos Julia Cunha , Cruz Aniel Feitosa da , de Souza Vitor Santos , Wanderley David Campos , Silva Ana Cristina Simoes e
Published: September 2022

Diethylene glycol (DEG) is nephrotoxic, potentially resulting in high morbidity and mortality. Its main nephrotoxic by-product is diglycolic acid (DGA). This narrative overview summarizes selected literature with a focus on clinical findings, pathophysiology, diagnosis including morphological features of renal biopsies, and management. The kidney injury in DEG poisoning is secondary to proximal tubular necrosis caused by DGA. Marked vacuolization and edema of epithelial cells obstruct the lumen, reducing urine flow and, consequently, resulting in anuria and uremia. The clinical alterations due to DEG poisoning are dose-dependent. Patients may present with gastrointestinal symptoms and anion gap metabolic acidosis, followed by renal failure, and, later, encephalopathy and neuropathy. Although this three-phase pattern has been described, signs and symptoms may be overlapping. Data about DEG intoxication is scarce. Sometimes the diagnosis is challenging. The management includes supportive care, gastric decontamination, correction of acid-base disorders, and hemodialysis. The understanding of the metabolic processes related to DEG poisoning may contribute to its management, preventing death, serious sequels, or irreversible lesions.
Renal Saturations and Acute Kidney Injury in the Preterm Infant with Patent Ductus Arteriosus
Authors: Rose Laura , Frymoyer Adam , Bhombal Shazia , Chock Valerie
Published: September 2022

Objective: Decreased near-infrared spectroscopy (NIRS) measures of renal saturation (Rsat) have identified hemodynamically significant PDA (hsPDA) and may delineate infants at risk for acute kidney injury (AKI).
Design: Review of infants 29 weeks gestation undergoing NIRS and echocardiography due to concern for PDA. hsPDA was defined by two of the following: moderate-large size, left to right shunt, aortic flow reversal, left atrial enlargement. AKI was defined by neonatal KDIGO. Rsat and cerebral saturation (Csat) were evaluated for 24 hours before echocardiography.
Result: Among 77 infants, hsPDA was found on echocardiography in 59 (77%). There were no differences in hsPDA in infants with and without AKI. Rsat was not associated with AKI (p=0.3) or hsPDA (p=0.5). Infants on dopamine had less Rsat variability (p=0.001).
Conclusion: Rsat prior to echocardiography did not discriminate AKI in the preterm hsPDA population, however data may not capture optimal timing of Rsat measurement before AKI.
WITHDRAWN: The climb that never ends: is the intergenerational upward mobility a predictor of individual preference for redistribution? The Hong Kong case.
Authors: Ippolito Marzia , Gaeta Giuseppe Lucio
Published: September 2022

This paper studies the link between intergenerational mobility and preferences for redistribution among Hongkongers. Using cross-sectional microdata, we support the hypothesis that climbing the income ladder triggers more favourable attitudes towards redistribution. However, we provide evidence that this happens especially among those who, despite the income mobility, still lay at the bottom of the income scale.
JEL codes: D31, D72, H23
Improved Diagnostic Accuracy and Sensitivity to Longitudinal Change in ALS with Multimodal MRI of the Brain and Cervical Cord
Authors: Pisharady Pramod , Eberly Lynn , Adanyeguh Isaac , Manousakis Georgios , Guliani Gaurav , Walk David , Lenglet Christophe
Published: September 2022

We demonstrate high sensitivity for detecting longitudinal change as well as diagnostic sensitivity in ALS by applying recent advances in MRI data acquisition and analysis to multimodal brain and cervical spinal cord data. We acquired high quality diffusion MRI data from the brain and cervical cord, and high quality T1 data from the brain, of 20 participants with ALS and 20 healthy control participants. Ten participants with ALS and 14 healthy control participants, and 11 participants with ALS and 13 healthy control participants were re-scanned at 6-month and 12-month follow-up visits respectively. We analyzed cross-sectional differences and longitudinal changes in brain diffusion metrics and cortical thickness to identify white and gray matter areas affected by the disease. We also used fixel-based microstructure measures, i.e. fiber density and fiber cross-section, that are found more sensitive to longitudinal changes. Combining the brain metrics with our previously reported diffusion and cross-sectional area measures of the spinal cord, we demonstrate improved disease diagnostic accuracy and sensitivity through multimodal analysis of cross-sectional data, including high sensitivity for diagnosis of lower motor neuron-predominant ALS. Fiber density and cross-section provided the greatest sensitivity for change in our longitudinal dataset. We demonstrate evidence of progression in a cohort of 11 participants with slowly progressive ALS, including in participants with very slow change in ALSFRS-R (less than 0.5 points per month). More importantly, we demonstrate that longitudinal change is detectable at a six-month follow-up visit. Our findings suggest that fixel-based measures may serve as potential biomarkers of disease progression in clinical trials. We also provide a comprehensive list of affected areas both in the white matter and cortical gray matter, and report correlations between ALSFRS-R and the fiber density and cross-section.
Paleomagnetic evidence for episodic construction of the Mamiyadake tephra ring
Authors: YASUDA YUKI
Published: September 2022

Tephra rings that surround maar craters are typically inferred from field observations to be emplaced rapidly over a time period of days to years and thus monogenetic, which is, however, rarely assessed quantitatively. This paper reports the discovery of polygenetic origin of the Mamiyadake tephra ring (Japan), comparing the paleomagnetic directions obtained from throughout the stratigraphy. The new data show that the paleomagnetic directions change systematically with height through the sections, which is interpreted to record paleosecular variation (PSV) of the geomagnetic field during formation of the tephra ring. The paleomagnetic results, together with using an average rate of PSV in Japan, indicate that the Mamiyadake tephra ring was constructed episodically with five major eruptive episodes, separated by centuries or longer, over at least 1000 years. The findings demonstrate that detailed paleomagnetic characterization can uncover the temporal evolution of tephra rings, providing a useful criterion for identifying time breaks, even where field evidence is lacking, and a minimum estimate of the time interval for their emplacement. The approach used here may be applicable to volcanoes of any type.
Bioinspired Smart Dual-Responsive Actuator with Janus Structure and Complete Biodegradability
Authors: Yang Tiantian , You Jingxuan , Yin Chunchun , Zhang Jinming , Wang Yirong , Zhang Jun
Published: September 2022

Smart materials that respond to external stimuli are the top choice as actuators. Herein, inspired by the natural plants, a smart dual-responsive actuator with Janus structure was fabricated from natural cellulose. Two cellulose derivatives with controllable chemical structure acted as the responsive elements, including ethanol-responsive cellulose 3,5-di-tert-butyl-4-hydroxybenzoate (CBH) and water-responsive carboxymethyl cellulose (CMC). Via changing the degree of substitution of 3,5-di-tert-butyl-4-hydroxybenzoate, the solubility, swellable property and swellable ratio of CBH in ethanol were precisely adjusted. After transforming the partial carboxylate group into the carboxylic acid, water-swellable CMC was obtained. Combining the ethanol-swellable CBH with water-swellable CMC by two-step blade-coating process, a Janus film was fabricated with dual-driven motility and complete biodegradability. This eco-friendly dual-responsive film can predict the concentration of ethanol/water mixture according to the different deformation angle. Moreover, it can be acted as a dual-responsive single-pole double-throw switch, indicating a huge potential in practical eco-friendly actuator.
Soil-transmitted helminth infection among school-age children in Ogoja, Nigeria: implication for control
Authors: Imalele Edema Enogiomwan , Braide Ekanem Ikpi , Emanghe Ubleni Etta , Effanga Emmanuel Offiong , Usang Anok Ukam
Published: September 2022

The study aimed at assessing the prevalence and risk factors of soil-transmitted helminthiases amongst school-aged children in Ogoja Local Government Area, Cross River State. Faecal samples were collected from 504 participants and analysed using the Kato-Katz technique. A total of 232 (46.0%) samples were positive for soil-transmitted helminths. The overall prevalence of Ascaris lumbricoides, hookworm, Trichuris trichiura, and Strongyloides stercoralis were 14.1%, 16.5%, 2.6%, and 12.9% respectively. The prevalence of infections were higher among males (46.6%) than females (45.4%). Overall parasitic infection was higher in the 5–7 year age group (65.6%) than in the other age groups (p = 0.000). Infection intensities of A. lumbricoides (84.00 EPG) (p = 0.044) and T. trichiura (96.00 EPG) (p = 0.041) were higher in school-age children aged 14–16 years. A. lumbricoides and hookworm co-infection (8.7%) was the most common mixed infection and was significantly higher in males than females. School-aged children who did not have prior knowledge about soil-transmitted helminth infections, the habit of drinking water without boiling, open defecation, use of pit latrine and children who did not have toilet facilities in school were significantly associated with soil-transmitted helminthiases. There was a significant relationship between washing hands after using the toilet, the habit of putting on footwear outside the house, and soil-transmitted helminth infection. In addition to preventive chemotherapy, control measures should focus on health education, providing clean drinking water, proper disposal of human excreta and sewage, and environmental hygiene.
An Extensive Survey on the Use of Supervised Machine Learning Techniques in the Past Two Decades for Prediction of Drug Side Effects
Authors: Das Pranab , Mazumder Dilwar Hussain
Published: September 2022

Side Effects (SE) of drugs are one of the common reasons for drug failure that may halt the whole drug discovery pipeline. Therefore, predicting the side effects of the drug is vital in drug development, discovery, and design. Supervised machine learning-based side effects prediction task has recently received much attention since it reduces time, chemical waste, design complexity, risk of failure, and cost. The advancement of supervised learning approaches for predicting side effects have emerged as essential computational tools. Still, there are several challenges to predict drug side effects. Thus, a near-exhaustive survey is carried out in this paper on the use of supervised machine learning approaches employed in drug side effects prediction in the past two decades. In addition, this paper also summarized the drug descriptor required for the side effects prediction task, commonly utilized drug properties sources, computational models, and their performances. Finally, the research gap, open problems, and challenges for the further supervised learning-based side effects prediction task have been discussed.
The Effect of Ultrasonication on the Fibrillar/ Oligomeric Structures of Aβ 1-42 at Different Concentrations
Authors: Faridi Nassim , Sanjay-Pour Maryam , Wang Ping , Bathaie S. Zahra
Published: September 2022

The number of disease states linked the aberrant regular protein conformations to oligomers and amyloid fibrils. Amyloid beta 1–42 (Aβ1−42) peptide is very hydrophobic and quickly forms the β-rich structure and fibrillar protein aggregates in some solutions and buffer conditions. Ultrasonication pulses can disrupt amyloid fibrils to smaller fragments and produce Aβ1−42 peptides of different sizes and oligomers. Herein, we investigated the effects of buffer and ultrasonication on Aβ1−42 structure at low and high concentrations. The electrophoresis and Western blot results showed that Aβ1−42 fibrils were disrupted into different sizes after ultrasonication. The transmission electron microscopy results indicated Aβ1−42 at low concentration (25 µM) in Ham’s/F12 phenol red-free culture medium formed short-size fragments and oligomers. In comparison, Aβ1−42 at higher concentration (100 µM) formed fibrils that break down into smaller fragments after ultrasonication. However, after regrowth, it formed mature fibrils again. The cell cytotoxicity results indicated more toxicity of Aβ1−42 oligomers formed at low concentration (25 µM) against PC12 cells than other forms. In conclusion, by applying ultrasonication pulses and controlling peptide concentration and buffer condition, we can rich Aβ1−42 aggregates with a particular size and molecular structure.
Impaired insulin-stimulated myocardial glucose metabolic rate is associated with reduced myocardial energetic efficiency
Authors: Succurro Elena , Cicone Francesco , Papa Annalisa , Miceli Sofia , Vizza Patrizia , Fiorentino Teresa Vanessa , Perticone Maria , Sciacqua Angela , Guzzi Pietro Hiram , Veltri Pierangelo , Cascini Giuseppe Lucio , Andreozzi Francesco , Sesti Giorgio
Published: September 2022

Background: Alterations in myocardial mechano-energetic efficiency (MEEi), which represents the capability of the left ventricles to convert the chemical energy obtained by oxidative metabolism into mechanical work, have been associated with cardiovascular disease. Although whole-body insulin resistance has been related to impaired myocardial MEEi, it is unknown the relationship between cardiac insulin resistance and MEEi. Aim of this study was to evaluate the relationship between insulin-stimulated myocardial glucose metabolic rate (MrGlu) and myocardial MEEi in subjects having different degrees of glucose tolerance.
Methods: We evaluated insulin-stimulated myocardial MrGlu using cardiac dynamic positron emission tomography (PET) with 18F-Fluorodeoxyglucose (18F-FDG) combined with euglycemic-hyperinsulinemic clamp, and myocardial MEEi in 57 individuals without history of coronary heart disease having different degrees of glucose tolerance. The subjects were stratified into tertiles according to their myocardial MrGlu values.
Results: After adjusting for age, gender and BMI, subjects in I tertile showed a decrease in myocardial MEEi (0.31±0.05 vs 0.42±0.14 ml/sec*g, P=0.02), and an increase in myocardial oxygen consumption (MVO2) (10153±1375 vs 7816±1229 mmHg*bpm, P<0.0001) as compared with subjects in III tertile. Univariate correlations showed that insulin-stimulated myocardial MrGlu was positively correlated with MEEi and whole-body glucose disposal, and negatively correlated with waist circumference, fasting plasma glucose, HbA1c and MVO2. In a multivariate regression analysis running a model including several CV risk factors, the only variable that remained significantly associated with MEEi was myocardial MrGlu (b 0.346; P=0.01).
Conclusions: These data suggest that an impairment in insulin-stimulated myocardial glucose metabolism is an independent contributor of depressed myocardial MEEi in subjects without history of CHD.
Biofunctionalized carbon nanotubes as a smart nanomaterial immobilized on a tissue culture polystyrene plate for promoting neuronal outgrowth
Authors: Kim Hyun-Soo , Leong Kam W. , Kim Gi Jin , Shin Ueon Sang , Kim Hae-Won , Hwang Ji-Young
Published: September 2022

Carbon nanotubes (CNTs) offer attractive attributes that are useful in innovative biomaterial design for neuroscience research due to their nanoscale features, modifiable chemical functionalities, and tunable electrical properties. In this study, we developed a simple and cost-effective fabrication method for advanced surface-modified cell culture system by immobilizing biofunctionalized CNTs onto commercial tissue culture polystyrene plates. This active substrate was examined to understand the effects of electrical, morphological, and chemical interactions with CNT-entrapped drug, bpV as a PTEN inhibitor, on the neuronal differentiation of PC-12 cells. Compared to control, the percentage of neuronal cells stimulating neurites increased by a factor of 4.0, 7.8, and 10.0, when cultured on immobilized carboxylated CNT substrate, PEGylated CNT substrate, and PEGylated CNT substrate in the presence of 10 nM bpV, respectively. The bpV-loaded CNT substrates down-regulated the expression of PTEN and up-regulated the Akt/ERK signaling pathway, thereby providing the mechanism for the improved neuronal outgrowth. These results highlight the promise of the biofunctionalized CNTs as the electroactive and drug-releasing smart nanomaterials for promoting neuronal outgrowth and suggest their potential utility in future neural regeneration applications.
Pre-biologic screening and biologic monitoring in a tertiary dermatology department in Ireland
Authors: Howard-James Claudine , Malouf Martine Malouf , O'Brennan Eimear
Published: September 2022

Introduction
Biologic therapies are important treatments for dermatological conditions. They have immense therapeutic benefit, but they are not without side effects.
Aim
This audit plans to evaluate adherence to the British Association of Dermatology guidelines for biologic therapy for psoriasis.
Methods
We retrospectively identified patients attending Dermatology OPD established on biologic therapy for a diagnosis of psoriasis, hidradenitis suppurativa(HS) or necrobiosis liopoidica(NL). A chart review was carried out. Records were anonymised and analysed to identify demographics, primary diagnosis, biologic agent and associated investigations.
Results
In total, 50 patients were audited. Median age was 46 with 58% being female. Primary diagnosis was psoriasis in 82%, HS in 30% and NL in 2%. Seven patients(14%) had dual diagnoses of psoriasis and HS.
Seven biologic agents were in use in this cohort; most commonly Adalimumab(in 52%), then Ustekinumab(26%) and Etanercept(8%).
At baseline, disease severity scores were documented in 68% and 87% had a full viral screen. Vaccination status was documented in 80%. In groups eligible for national screening programmes; <37.5% were asked about participation. Of 19 women of childbearing potential, 21% were asked about pregnancy planning.
At last review, disease severity was documented in 94% and minimal response criteria met in 84%.
Conclusion
We identified areas of strengths and weakness in biologic pre-screening and monitoring. Strengths include viral screening, weaknesses include family planning discussions. We created screening and monitoring checklists which are being implemented in our tertiary Dermatology OPD. We plan to re-audit in six months, to include a larger sample size.
Two-dimensional Numerical Simulation of Suspended Sediment Transport in Lobo Reservoir(Western-central of Côte D’ivoire)
Authors: Koffi Bérenger , Sanchez Martin , Kouamé Kouadio Jean Olivier , Amemou Hilaire , Yangouliba Gnibga Issoufou , Kouassi Kouakou Lazare
Published: September 2022

Built to improve the water supply of the populations of the city of Daloa, the water reservoir of the Lobo River is no longer functioning properly due to sedimentation phenomena. This study aims to understand the hydro-sedimentary functioning of the reservoir for better management. Based on the river flows, bathymetric surveys, suspended solids concentrations, settling velocity, a two-dimensional modelling of the flows and sedimentation of the Lobo River reservoir was carried out using the MIKE 21FM/MT software. The simulation results indicate that the hydrodynamic model could reproduce the variation of water levels at the free surface of the reservoir. The results are very sensitive to the boundary conditions of the model but also to the initial conditions. A strong influence of the initial conditions on the long-term stability of the models was observed. It could be seen that in all cases the deposition rate tends towards a final value which only depends on the river flow. The trapping efficiency of the reservoir is between 26.7% and 80.4%. The different simulation scenarios indicate that the deposition thicknesses are between 0.02 and 48 mm and that the deposition occurs when the flow is loaded, during the rise and fall phase of the hydrograph. The old intake, the new intake and the weir are the preferred areas for sediment deposition in the Lobo reservoir.
Prophylactic endoscopic double endoloop hemostasis for large pedunculated colorectal polyps with a stalk: a single-center study (with video)
Authors: Ai Xinbo , Zhou Bin , Huang Yaoming , Lai Linmin , Wang Zhenjiang , Xu Xiaohong , Chen Yuping
Published: September 2022

Background and Aims: This study aimed to explore a novel prophylactic endoscopic therapy for post-polypectomy bleeding of larger colon polyps with a stalk (≥15 mm) and improve clinical outcomes. We also evaluated the feasibility and safety of prophylactic double endoloop hemostasis (PDEH) for larger colon polyps with a stalk (≥15 mm). Methods: This single-center prospective study included 16 patients with larger colon polyps with stalks (≥15 mm) between January 2020 and March 2022. The first endoloop (MAJ-254, MAJ-340; Olympus, Tokyo, Japan) was positioned at the base of the stalk, followed by conventional snare polypectomy. The second endoloop passed through the tail of the first endoloop and slowly approached the base. It was then successfully placed near the first endoloop to decrease the possibility of delayed bleeding. Results: A total of 16 enrolled patients underwent complete endoscopic resection, as confirmed by histopathology (three females, 13 males). The mean age of the patients was 49.8±13.8 years, and 10 patients had polyps in the sigmoid colon (62.5%). The mean diameter of all polyps was 25.6±9.5 mm, and the largest polyp had a diameter of 50 mm. Meanwhile, the mean width of the pedunculated polyps was 7.5±1.3 mm. Only six patients underwent cap-assisted endoscopic polypectomy (46.1%). The mean procedure time was 11.5±2.8 min with or without cap assistance. Additionally, the mean hospital stay was 1.7±0.4 days. Conclusions: PDEHwas found to be a feasible and safe technique for larger pedunculated colon polyps.
Progress on the unfair 0-1-polynomials conjecture using linear recurrences and numerical analysis
Authors: Ghidelli Luca
Published: September 2022

If the product of two monic polynomials with real nonnegative coefficients has all coefficients equal to 0 or 1, does it follow that all the coefficients of the two factors are also equal to 0 or 1? % Here is an equivalent formulation of this intriguing problem: is it possible to weigh unfairly a pair of dice so that the probabilities of every possible outcome (roll them and take the sum) were the same? If the two dice have six faces numbered 1 to 6, it is easy to show that the answer is no. But for general dice with finitely many faces, this is an open problem with no significant advancement since 1937. In this paper we examine, in some sense, the first infinite family of cases that cannot be treated with classical methods: the first die has three faces numbered with 0,2 and 5, while the second die is arbitrary. In other words, we examine factorizations of 0-1-polynomials with one factor equal to x5+a x2 +1 for some nonnegative a. We discover that this case may be solved (that is, necessarily a=0 or a=1) using the theory of linear recurrence sequences, computation of resultants, as well as analytic and numerical approximations.
2020
MSC Classification: Primary 12D05 , 60B15 , 60-08 , 11B39 , 13P15 , 26C10; Secondary 00A08 , 11C08 , 60A10 , 11C20 , 26A05 , 26D05 , 65H04.
WITHDRAWN: Deeply understanding delivery of Tetracycline under different morphologies of ZIF-8
Authors: Luan Tran Ba , Lam Nguyen Truong
Published: September 2022

Facile and biocompatible fabrication of ZIF-8 (zeolite imidazole framework) and its modifications are reported in two ways: TiO2@ZIF-8 and creating mesoporous. Adding a small amount of surfactant changes the traditional crystal morphology to mesoporous and reduces the amount of base needed compared to normal synthesis, thus minimizing environmental impact. The resulting crystals were characterized by X-ray diffraction (XRD), Scanning electron microscopy (SEM), Infrared Spectroscopy meter (FTIR), and nitrogen adsorption measurements, which revealed the mesoporous and TiO2@ZIF-8 with polyhedral morphology. The examination of Tetracycline (TC) delivery was thoroughly studied on these hybrids ZIF-8. The loading and release of TC were controlled under the influence of factors such as morphology, and electrostatic force... by experiment data and estimating mechanism. For the first time, the number of molecules of TC adsorbed outer ZIF-8 surface area and inside its structure was investigated. This study demonstrates a green synthesis of mesoporous and TiO2@ZIF-8, maintaining an excellent yield and scalability, successfully applying for TC delivery study, and exposes the important effects of the porous structure on drug loading and release.
Serum Metabolomic Profiles for Human Gastric Adenocarcinoma Discrimination
Authors: Zhu Cailin , Liu Hui , Li Hongtao , Bi Weiyun , Bai Bin , Zhao Qingchuan
Published: September 2022

As one of the most common cancers, Gastric cancer (GC) exhibits high incidence and mortality. Recent studies have indicated that serum tumor markers can provide valuable diagnostic information for GC. In this study, we examine the clinicopathological significance of preoperative serum tumor markers and serum metabolites on gastric adenocarcinoma patients. We first perform the serum metabolic profiling of 139 gastric adenocarcinoma patients and 156 healthy controls by the Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS). Based on these chemometric results, we then identify three metabolites, namely phosphatidylcholine (PC) (34:1), palmitoyl-L-carnitine and m/z 361.234, as “potential marker metabolites”. Finally, we perform the ROC curve analysis on the three potential marker metabolites to distinguish the 12 early gastric adenocarcinoma patients from healthy controls. Our analysis has yielded an AUC of 0.973, with 91.7% on sensitivity and 93.6% on specificity at the best cut-off point. Our study has empirically shown that serum metabolomics is amenable for the minimally invasive diagnosis of human gastric adenocarcinoma.
Sailing past the End of the World and discovering the Island
Authors: Anous Tarek , Meineri Marco , Pelliconi Pietro , Sonner Julian
Published: September 2022

Large black holes in anti-de Sitter space have positive specific heat and do not evaporate. In order to mimic the behavior of evaporating black holes, one may couple the system to an external bath. In this paper we explore a rich family of such models, namely ones obtained by coupling two holographic CFTs along a shared interface (ICFTs).
We focus on the limit where the bulk solution is characterized by a thin brane separating the two individual duals. These systems may be interpreted in a double holographic way, where one integrates out the bath and ends up with a lower-dimensional gravitational braneworld dual to the interface degrees of freedom. Our setup has the advantage that all observables can be defined and calculated by only relying on standard rules of AdS/CFT. We exploit this to establish a number of general results, relying on a detailed analysis of the geodesics in the bulk. Firstly, we prove that the entropy of Hawking radiation in the braneworld is obtained by extremizing the generalized entropy, and moreover that at late times a so-called `island saddle' gives the dominant contribution. We also derive Takayanagi's prescription for calculating entanglement entropies in BCFTs as a limit of our ICFT results.
The linkage between green banking practices and green loyalty: A customer perspective
Authors: S. Pawar Deepthi , Munuswamy Jothi
Published: September 2022

The aim of this study is to explore the bank customers’ perceptions towards green banking practices. This study uses a convenient sampling method. Pre-tested questionnaires were employed to collect data. The data were collected conveniently from 358 bank customers. However, the final sample includes 304 responses after ignoring null responses (n = 304). The Structural equation modeling (SEM) was applied for the analyses. The significant results of the study indicate that green banking practices positively influence green image (p = 0.001) and green trust (p = 0.025), while it does not significantly affect green loyalty (p = 0.642). The mediation analysis reveals that green image mediates the relationship between green banking practices and green loyalty, while green trust does not mediate the relationship between the same. The results have practical implications for banking institutions in India to recognize the importance of environmental initiatives in influencing the decisions of bank customers.
Pengaruh Penggunaan Internet Terhadap Minat dan Perilaku Belajar Siswa
Authors: Rizalia Syarif , Sunartin Sunartin , Mansyur Mansyur
Published: September 2022

Tujuan penelitian ini adalah mengetahui pengaruh penggunaan internet terhadap minat belajar biologi siswa, mengetahui pengaruh penggunaan internet terhadap perilaku belajar biologi siswa, dan mengetahui pengaruh penggunaan internet terhadap minat dan perilaku belajar biologi siswa. Penelitian ini merupakan penelitian kuantitatif dengan menggunakan metode Survey (menggunakan angket). Hasil penelitian menunjukkan bahwa: 1) Penggunaan internet berpengaruh positif dan signifikan terhadap minat belajar Biologi siswa, dibuktikan dengan nilai signifikansi 0,000 0,05 sehingga H1 diterima, yang berarti terdapat pengaruh positif dan signifikan antara variabel X terhadap variabel Y1; 2) Penggunaan internet berpengaruh positif dan signifikan terhadap perilaku belajar Biologi siswa, dibuktikan dengan nilai signifikansi 0,000 0,05 sehingga H1 diterima, yang berarti terdapat pengaruh positif dan signifikan antara variabel X terhadap variabel Y2; 3) Penggunaan internet berpengaruh simultan terhadap minat dan  perilaku belajar, dibuktikan dengan nilai simultan yang didapatkan dari hasil uji manova (Multivariate Analysis of Anova) dengan nilai signifikansi rata-rata berada dibawah 0,05.
Erva-Mate e a Conservação dos Ervais Nativos na Argentina
Authors: Gerhardt Marcos
Published: September 2022

Aborda a história das sociedades humanas que, no território argentino, se dedicaram à extração, ao beneficiamento e ao comércio da erva-mate (Ilex paraguariensis, St. Hilaire) ou foram consumidores do produto durante a segunda metade do século XIX e nas primeiras décadas do século XX. Aborda, ainda, os esforços para a conservação dos ervais nativos, que eram parte da floresta e a rápida transformação dessa paisagem em áreas desmatadas designadas aos cultivos agrícolas e ao plantio de ervais. Emprega a abordagem da História Ambiental e utiliza variadas fontes de pesquisa, com destaque para os documentos oficiais, publicações na imprensa periódica e a produção bibliográfica da época. Conclui que a legislação de proteção aos ervais nativos e as políticas públicas foram insuficientes para a sua conservação, prevalecendo os interesses econômicos que levaram à drástica redução dos ervais silvestres no período estudado.
Contra a Correnteza: Conservação, Restauração e Recuperação Ambiental no Vale do Rio Doce
Authors: Espindola Haruf Salmen , Vilarino Maria Terezinha Bretas , Souza Bianca de Jesus , Mifarreg Iesmy Elisa Gomes
Published: September 2022

O artigo parte da contação da expansão da história ambiental produzida no Brasil e sua centralidade em enredos trágicos, para redirecionar o olhar para aqueles que teimaram em ir contra a correnteza. Usa os estudos de casos para demonstrar a relevância de a história ambiental voltar-se com mais intensidade para a temática da conservação, restauração e recuperação ecológico/ambiental. Os estudos de casos são utilizados para estimular o redirecionamento do olhar do historiador ambiental para além da perspectiva trágica de devastação e colapso. Este artigo se propõe a apresentar três casos relacionados a iniciativas não-governamentais de conservação, restauração e recuperação no médio rio Doce/MG. No primeiro apresentamos a Reserva Privada de Patrimônio Natural – RPPN – Feliciano Miguel Abdala, no município de Caratinga; em seguida a experiência de restauração RPPN Fazenda Bulcão pelo Instituto Terra; e, finalmente, o esforço da ONG Centro Agroecológico Tamanduá da e recuperação de áreas degradadas, com destaque para a Comunidade Quilombola de Ilha Funda, no município de Periquito.
Usos de la Cartografía Histórica y la Toponimia en la Historia Ambiental Latinoamericana
Authors: Miraglia Marina
Published: September 2022

El estudio y análisis del ambiente en las últimas décadas y a nivel global, ha cobrado centralidad en las ciencias sociales y humanas, recientemente denominadas Humanidades Ambientales, tales como la Sociología, el Urbanismo, la Economía, la Antropología y la Arqueología, y especialmente la Geografía y la Historia, y dentro de ésta, la Historia Ambiental.
Del análisis historiográfico de las principales producciones académicas latinoamericanas de los últimos años, se observa el uso extendido de la Cartografía Histórica y la Toponimia, como fuentes de datos secundarios en investigaciones geográficas e históricas, al mismo tiempo que, en la Historia Ambiental, son recientes y escasas sus aplicaciones.
En este artículo, el principal objetivo es presentar los aportes de la Cartografía Histórica y la Toponimia como fuentes de datos históricos en el análisis e interpretación, en el marco de la Historia Ambiental, las relaciones territoriales y ambientales producidas entre los sistemas político, socio económicos, culturales y naturales.
Para una mejor comprensión de la importancia del uso de estas fuentes, se ejemplifican algunas aplicaciones de la Toponimia y Cartografía Histórica en la Historia Ambiental, a través de una selección de trabajos realizados en Argentina, Colombia, México y Chile en la última década.
The laparoscopic isolation of a splenic artery aneurysm: a case report
Authors: Odintsov N.S. , Belova Yu.K. , Vanyurkin A.G. , Kudaev Yu.A. , Neimark A.E. , Chernyavskiy M.A.
Published: September 2022

Splenic artery aneurysm is a rather rare abnormality, and its treatment is a pressing issue due to high morbidity and mortality in case of its rupture.Our aim is to show the advantages of the laparoscopy for splenic artery aneurysms.Patient P., 81 years old, was admitted for surgical treatment of the splenic artery aneurysm. Angiography revealed the tortuosity of the splenic artery with a 28-mm distal aneurysm. Laparoscopic treatment of the aneurysm was performed using a stapler. No complications were observed during the postoperative period, so the patient was discharged on day 5.The laparoscopic treatment is a method of choice in patients with a tortuos splenic artery and a distal aneurysm to spare a spleen.
Received 20 December 2021. Revised 13 April 2022. Accepted 26 April 2022.
Informed consent: The patient’s informed consent to use the records for medical purposes is obtained.
Funding: The study did not have sponsorship.
Conflict of interest: Authors declare no conflict of interest.
Contribution of the authorsLiterature review: A.G. Vanyurkin, Yu.A. KudaevDrafting the article: N.S. Odintsov, Yu.K. BelovaCritical revision of the article: A.E. Neimark, M.A. ChernyavskiySurgical treatment: A.E. NeimarkFinal approval of the version to be published: N.S. Odintsov, Yu.K. Belova, A.G. Vanyurkin, Yu.A. Kudaev, A.E. Neimark, M.A. Chernyavskiy
Evaluation of the Mechanism of Action of Rosemary Volatile Oil in the
Treatment of Alzheimer's Disease Using Gas Chromatography -mass
Spectrometry Analysis and Network Pharmacology
Authors: Zhou Peijie , Wang Xuan , Zhao Yijun , She Xinhua , Jia Yanzhuo , Wang Wenfei , Li Jia , Luo Xiangning
Published: September 2022

Objective:

This study aimed to investigate the active components and mechanism of action
of rosemary volatile oil for treating Alzheimer's disease (AD) using network pharmacology.

Methods:

We obtained the constituents of the rosemary volatile oil by searching Chinese herbal
systemic pharmacological databases and analytical platforms and constructed the constituent-target
networks by predicting and screening the action targets of the rosemary volatile oil constituents using
SwissTargetPrediction, metaTarFisher, and Pubchem. We obtained the AD-related targets using
the Genecards, OMIM, and DisGeNET databases and constructed the protein-protein interaction
networks (PPI) using the STRING database in Venny 2.1.0 graph to identify the cross-targets
by screening the core-acting targets. Cytoscape 3.8.2 software was used to construct a componenttarget-
pathway network to screen the potential active components of the rosemary volatile oil for
the treatment of AD and predict the mechanism of action of the rosemary volatile oil for the treatment
of AD in combination with existing pharmacological studies. We performed a gene ontology
(GO) biological process and a Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment
analysis of the targets of the rosemary volatile oil for the treatment of AD using R language and
molecular docking using Discovery Studio 4.0 software to validate their biological activities.

Results:

A network constructed using gas chromatography-mass spectrometry (GC-MS) analysis
identified 26 potentially active ingredients in the rosemary volatile oil. We retrieved a total of
10762 AD targets from Genecards and other databases. Our GO enrichment analysis yielded 39 entries
(P < 0.05), including 14 entries for biological processes, five entries for cellular composition,
and 20 entries for molecular function. A total of 14 entries (P < 0.05) were then enriched in the
KEGG pathway that primarily involved the IL-17 signaling pathway and the AGE-RAGE pathway.

Conclusion:

The active components of rosemary volatile oil had good inhibition of the inflammatory
response. This study provides a reference and guidance for the in-depth study on rosemary
volatile oil for the treatment of AD.