bluuebunny/crossref_metadata_2025 huggingface dataset:
Snrpb is required in murine neural crest cells for proper splicing and craniofacial morphogenesis
Authors: Alam Sabrina Shameen , Kumar Shruti , Beauchamp Marie-Claude , Bareke Eric , Boucher Alexia , Nzirorera Nadine , Dong Yanchen , Padilla Reinnier , Zhang Si Jing , Majewski Jacek , Jerome-Majewska Loydie A.
Published: May 2022

Heterozygous mutations in SNRPB, an essential core component of the five small ribonucleoprotein particles of the spliceosome, are responsible for cerebrocostomandibular syndrome (CCMS). We show that Snrpb heterozygous mouse embryos arrest shortly after implantation. Additionally, heterozygous deletion of Snrpb in the developing brain and neural crest cells models craniofacial malformations found in CCMS, and results in death shortly after birth. RNAseq analysis of mutant heads prior to morphological defects revealed increased exon skipping and intron retention in association with increased 5′ splice site strength. We found increased exon skipping in negative regulators of the P53 pathway, along with increased levels of nuclear P53 and P53 target genes. However, removing Trp53 in Snrpb heterozygous mutant neural crest cells did not completely rescue craniofacial development. We also found a small but significant increase in exon skipping of several transcripts required for head and midface development, including Smad2 and Rere. Furthermore, mutant embryos exhibited ectopic or missing expression of Fgf8 and Shh, which are required to coordinate face and brain development. Thus, we propose that mis-splicing of transcripts that regulate P53 activity and craniofacial-specific genes contributes to craniofacial malformations.

This article has an associated First Person interview with the first author of the paper.
VEGF-A controls the expression of its regulator of angiogenic functions, dopamine D2 receptor, on endothelial cells
Authors: Sarkar Chandrani , Chakroborty Debanjan , Goswami Sandeep , Fan Hao , Mo Xiaokui , Basu Sujit
Published: May 2022

We have previously demonstrated significant upregulation of dopamine D2 (DAD2) receptor (DRD2) expression on tumor endothelial cells. The dopamine D2 receptors, upon activation, inhibit the proangiogenic actions of vascular endothelial growth factor-A (VEGF-A, also known as vascular permeability factor). Interestingly, unlike tumor endothelial cells, normal endothelial cells exhibit very low to no expression of dopamine D2 receptors. Here, for the first time, we demonstrate that through paracrine signaling, VEGF-A can control the expression of dopamine D2 receptors on endothelial cells via Krüppel-like factor 11 (KLF11)-extracellular signal-regulated kinase (ERK) 1/2 pathway. These results thus reveal a novel bidirectional communication between VEGF-A and DAD2 receptors.
The physiological cost of colour change: evidence, implications and mitigations
Authors: Alfakih Ateah , Watt Penelope J. , Nadeau Nicola J.
Published: May 2022

Animals benefit from phenotypic plasticity in changing environments, but this can come at a cost. Colour change, used for camouflage, communication, thermoregulation and UV protection, represents one of the most common plastic traits in nature and is categorised as morphological or physiological depending on the mechanism and speed of the change. Colour change has been assumed to carry physiological costs, but current knowledge has not advanced beyond this basic assumption. The costs of changing colour will shape the evolution of colour change in animals, yet no coherent research has been conducted in this area, leaving a gap in our understanding. Therefore, in this Review, we examine the direct and indirect evidence of the physiological cost of colour change from the cellular to the population level, in animals that utilise chromatophores in colour change. Our Review concludes that the physiological costs result from either one or a combination of the processes of (i) production, (ii) translocation and (iii) maintenance of pigments within the colour-containing cells (chromatophores). In addition, both types of colour change (morphological and physiological) pose costs as they require energy for hormone production and neural signalling. Moreover, our Review upholds the hypothesis that, if repetitively used, rapid colour change (i.e. seconds–minutes) is more costly than slow colour change (days–weeks) given that rapidly colour-changing animals show mitigations, such as avoiding colour change when possible. We discuss the potential implications of this cost on colour change, behaviour and evolution of colour-changing animals, generating testable hypotheses and emphasising the need for future work to address this gap.
Rhodium-catalyzed C6-Selective Alkoxycarbonylation of Pyridones
Authors: Suzuki Hirotsugu , Ito Yuki , Matsuda Takanori
Published: May 2022

A novel method for the rhodium-catalyzed C6-selective alkoxycarbonylation of 2-pyridones is developed. This protocol offers a facile and direct synthetic route to 2-pyridone-6-carboxylates, for which C–H functionalization has never been realized. The reaction proceeds without the use of a stoichiometric additive and by using dialkyl dicarbonates as the alkoxycarbonyl source. The protocol can be successfully employed for a large-scale reaction.
Μελέτη αναγκαιότητας μασχαλιαίου λεμφαδενικού καθαρισμού σε γυναίκες με θετικούς (≤3) φρουρούς λεμφαδένες σε καρκίνο μαστού σταδίου Τ1-2
Authors: Περιστέρη Δήμητρα
Published: May 2022

Ο μασχαλιαίος λεμφαδενικός καθαρισμός (ΛΚΜ) αποτελεί ουσιαστικό μέρος της χειρουργικής θεραπείας για τον πρώιμο διηθητικό καρκίνο του μαστού σε περιπτώσεις 3 ή περισσότερων θετικών λεμφαδένων φρουρών(ΛΦ) ή σε κλινικά θετική εξέταση της μασχάλης προεγχειρητικά. Συμβάλλει σημαντικά όχι μόνο στη σταδιοποίηση της νόσου, αλλά και στον ογκολογικό έλεγχο της σύστοιχης μασχαλιαίας χώρας. Παρόλα αυτά, σύμφωνα με πρόσφατες διεθνείς μελέτες, ο ΛΚΜ δεν φαίνεται να υπερτερεί συγκριτικά με την απλή βιοψία των φρουρών λεμφαδένων σε ασθενείς με περιορισμένες≤ 3 μεταστάσεις στους λεμφαδένες αυτούς. Για τον λόγο αυτό δεν πρέπει να θεωρείται ως πρώτη γραμμή θεραπείας στο συγκεκριμένο πληθυσμό ασθενών.Σκοπός της παρούσας διατριβής ήταν μελετήσει την υπεροχή ή όχι (non-inferiority) του ΛΚΜ ως προς την επίπτωση λεμφοιδήματος, άλγους άνω άκρου, διαταραχών κινητικότητας του ώμου καθώς και πιθανότητας τοπικής υποτροπής της σύστοιχης μασχάλης συγκριτικά με την απλή βιοψία του λεμφαδένα φρουρού σε ασθενείς με T1-2 καρκίνο μαστού που έχουν ≤3 θετικούς ΛΦ και που υποβάλλονται είτε σε Ευρεία Τοπική Εκτομή (ΕΤΕ) ή Ολική Μαστεκτομή (ΟΜ) και Ακτινοθεραπεία.Υλικό-Μέθοδοι: Η μελέτη παρατήρησης συμπεριέλαβε συνολικά 99 ασθενείς, για το χρονικό διάστημα από Δεκέμβριο 2015- Μάϊο 2021. Στη μελέτη συμπεριλήφθηκαν όλοι οι ασθενείς με καρκίνο μαστού σταδίου ΤI-II (cT<5cm) με κλινικά μη ψηλαφητούς μασχαλιαίους λεμφαδένες (cN0) οι οποίοι υποβλήθηκαν είτε σε ΕΤΕ ή ΟΜ και διεγχειρητική βιοψία ΛΦ. Χωρίσθηκαν σε δυο ομάδες ΛΦ-ΛΚΜ. Η ομάδα ελέγχου περιλάμβανε τις ασθενείς που στην ταχεία βιοψία του ΛΦ και σε περίπτωση θετικού λεμφαδένα ακολούθησε ΛΚΜ σε συνδυασμό με χημειοθεραπεία/ορμονοθεραπεία. Η ομάδα ασθενών περιέλαβε τις ασθενείς που είχαν ≤3 θετικούς ΛΦ στην ταχεία βιοψία και διεγχειρητικά δεν προχώρησαν σε ΛΚΜ αλλά ακολούθησαν το πρωτόκολλο μετεγχειρητικής ακτινοβολίας σε συνδυασμό με χημειοθεραπεία/ορμονοθεραπεία. Αποτελέσματα: Η πιθανότητα λεμφοιδήματος > 3 εκατοστών είναι σημαντικά υψηλότερη στους ασθενείς με επέμβαση ΛΚΜ (OR=50 με 95% διάστημα εμπιστοσύνης 10,75 – 250). Η πιθανότητα μειωμένης κινητικότητας του ώμου είναι σημαντικά υψηλότερη στους ασθενείς με επέμβαση ΛΚΜ (OR=5,56 με 95% διάστημα εμπιστοσύνης 2,049 – 14,925), όπως επίσης και η πιθανότητα άλγους σύστοιχου άνω άκρου είναι σημαντικά υψηλότερη στην ίδια ομάδα ασθενών (OR=9,433 με 95% διάστημα εμπιστοσύνης 3,759 – 23,809). Τέλος, η πιθανότητα τοπικής υποτροπής της σύστοιχης μασχάλης είναι ισότιμα ανάλογη και στα δύο είδη επεμβάσεων.Συμπέρασμα: Συνιστούμε την αποφυγή του ΛΚΜ σε ασθενείς με πρώιμο καρκίνο του μαστού Τ1-2, με λιγότερους από τρεις θετικούς ΛΦ (είτε μικρομεταστάσεις ή μακρομεταστάσεις). Η παράλειψη του ΛΚΜ είναι επί του παρόντος η καλύτερη δυνατή θεραπευτική επιλογή, δεδομένου ότι οι ασθενείς μπορούν εναλλακτικά και με ασφάλεια να λάβουν ακτινοθεραπεία, κατάλληλη συστηματική χημειοθεραπεία ή/και ορμονική θεραπεία με σημαντικά μειωμένη νοσηρότητα και χωρίς επιπλέον κίνδυνο τοπικής υποτροπής.
Αναπαραστάσεις του θηλυκού στην ελληνική παιδική λογοτεχνία
Authors: Καρανικολάου Θεοπούλα
Published: May 2022

Η παιδική λογοτεχνία αποτελεί αναπόσπαστο κομμάτι της παιδικής ηλικίας, λειτουργώντας τόσο ως μέσο ψυχαγωγίας όσο και κοινωνικοποίησης των παιδιών. Μέσα από τις έμφυλες αναπαραστάσεις των βιβλίων, τα παιδιά διαμορφώνουν αντιλήψεις για το φύλο τους και προσλαμβάνουν πρότυπα συμπεριφοράς για τους έμφυλους ρόλους που θα κληθούν να παίξουν ως ενήλικες. Η παρούσα διατριβή μελετά τις αναπαραστάσεις του θηλυκού στην ελληνική παιδική λογοτεχνία της τελευταίας δεκαετίας και συγκεκριμένα για τα έτη 2009 - 2019, προκειμένου να διαπιστωθεί εάν το γυναικείο φύλο απεικονίζεται στερεοτυπικά στα σύγχρονα παιδικά βιβλία. Κατά την ανάλυση των βιβλίων λαμβάνονται υπόψη η θεωρία της φεμινιστικής λογοτεχνικής κριτικής, οι θεωρητικές προσεγγίσεις για τον εντοπισμό της ιδεολογίας σε λογοτεχνικά έργα, κείμενα και εικόνες, αλλά και οι σχετικές με τα φύλα κοινωνικές συνθήκες που επικρατούν στην Ελλάδα, όπως αυτά παρουσιάζονται στο θεωρητικό μέρος της διατριβής. Για τους σκοπούς της έρευνας επιλέχθηκε ένα τυχαίο δείγμα 45 βιβλίων, στο οποίο εφαρμόστηκε η μέθοδος ανάλυσης περιεχομένου σε κείμενα και εικόνες. Από την ανάλυση του δείγματος διαπιστώθηκε η αποσπασματική και στερεοτυπική απεικόνιση του θηλυκού στην πλειοψηφία των βιβλίων, με τους γυναικείους χαρακτήρες να εμφανίζονται συχνότερα σε δεύτερους ρόλους και παράλληλα να συγκεντρώνουν μια περιορισμένη γκάμα χαρακτηριστικών (εξωτερικής εμφάνισης, προσωπικότητας και κοινωνικής συμπεριφοράς), συμβατών με τα στερεότυπα του φύλου τους. Τα ευρήματα της έρευνας υποδεικνύουν ότι η παιδική λογοτεχνία διέπεται από έμφυλες προκαταλήψεις, παρέχοντας στα παιδιά-αναγνώστες περιοριστικά για το φύλο τους πρότυπα.
Research on desktop object grasping based on ellipse fitting
Authors: Zhang Shaolin , Ge Yueguang , Chang Wenkai , Wang Haitao , Wang Shuo
Published: May 2022

The grasping operation task in service scenes faces several problems including too many kinds of objects and a large amount of training data. This paper focuses on the grasping strategy and pose detection in desktop object grasping tasks. A grasping strategy is given based on the combination of desktop normal vector detection, object category detection, and grasping pose detection. The grasping pose is calculated by ellipse fitting on the depth map. An optimal function is designed to evaluate the possibility of the object sliding along the ellipse axis and the stability of the grasping height. The most reliable grasping pose is selected. Finally, experiments were carried out with a six-degree-of-freedom manipulator, and the proposed grasping method achieved effective grasping of desktop objects without prior knowledge of the object.
Unleashing frugal innovation in private higher education institutions via intellectual capital and Information technology capability: a systematic literature review
Authors: Jayabalan Jayamalathi , Dorasamy Magiswary , Raman Murali , Sambasivan Murali , Harun Sharbani
Published: May 2022

Background: Given the persistent challenges to the higher education business model, private higher education institutions (PHEIs) are exploring myriad ways to increase enrolment and income, while aggressively managing spending. Many PHEIs are facing financial distress and struggling because of decreasing budgets and declining revenue. Thus, carving unique strategies that direct the institution to focus on its core competencies, making additional budget cuts without compromising quality, developing new revenue streams, embracing new technology, and offering affordable programs, will ultimately lead to financial success. Frugal innovation (FI) can shed light on these challenges.

Methods: This paper presents a systematic literature review to investigate and analyse prior research that focused on FI within the sphere of intellectual capital (IC) and information technology capabilities (ITC) research, and their relationships in PHEIs. Transfield’s five phases were employed to extract journal articles published over a thirty-year period (1990 to 2020) from major online databases using keyword searches. Although an initial search generated 76,025 papers, the search for IC and FI yielded 41 papers, and finally only two papers were selected as they clearly related IC with FI.

Results: There was a research gap in the literature published from 1990 to 2020 regarding IC applications to achieve FI. This work revealed that IC and ITC research for FI in PHEI remain insufficiently explored.  

Conclusions: Further research is required on the evaluation model of IC, ITC and FI, methodologies, empirical analysis, and the development of measurement metrics. A limitation to this study is the number of keywords selected.
Implementing living evidence to inform health decisions: A strategy for building capacity in health sector (Protocol)
Authors: Rojas-Reyes María Ximena , Urrutia Chuchí Gerard , Rada Gabriel , Alonso Pablo , Rigau Comas David , Auladell-Rispau Ariadna
Published: May 2022

Every day important healthcare decisions are made with incomplete or outdated information about the effects of the healthcare interventions available, what delivers the best value for the health system and where more research is needed. It is necessary to invest in strategies that allow access to reliable and updated evidence on which to base health decisions.

The objective is to develop and evaluate a strategy for building the capacity among different actors of a country’s health system to implement the model known as “Living Evidence” [LE] in the evidence synthesis and dissemination of knowledge transfer [KT] products to inform health decisions. The study will involve professional members of health system organizations in charge of developing KT products to inform health decisions.

The project will be developed in three complementary phases: 1) LE-implementation framework development through review of the literature, brainstorming meetings, user testing, and expert consultation; 2) training in LE tools and strategies; 3) developing LE synthesis for KT products by applying the framework to real-life diverse situations.

To achieve the capacity-building strategy assessment goal, several surveys and interviews will take place during the process to assess: 1) the LE-implementation framework for the incorporation of LE synthesis in the development of KT products; 2) the training workshops; 3) the whole capacity-building strategy used for health system organizations be able of implementing the LE as part of the KT products they regularly produce.

The expected results are an effective capacity-building strategy for health system organizations to implement the living evidence model in different KT products; a LE-implementation framework to be applicable to any country or region to incorporate LE in the KT products; LE synthesis for KT products directly applicable to the real-setting situations; integration of Epistemonikos-L.OVE platform for keeping the LE process in the development and updating of KT products.
Pulmonary embolism in COVID-19
Authors: Ilyina-Stohniienko V. , Kharchenko Yu. , Zaretska A. , Savchuk A. , Kolotvin A.
Published: May 2022

COVID-19 pandemic is recognized as a present day major public health burden. Risk factors for developing a more severe course of COVID-19 include increased levels of C-reactive protein and D-dimer. Pulmonary embolism (PE) is challenging in patients with COVID-19. The purpose: to analyze clinical and paraclinical manifestations of PE in patients with COVID-19 in order to develop a system for its early diagnosis, prediction of complications, prevention and treatment. 52 patients aged 28 - 81 y.o. with a diagnosis "Acute respiratory disease COVID-19" have been examined during 2020-2021. (98.08±1.9)% of PE patients had a history of one or more comorbidities, including obesity (80.77%), coronary heart disease (96.15%), hypertension (98.08%), peripheral arteries (92.3%), type 2 diabetes mellitus (48.08%). Evaluation of laboratory parameters revealed increasing lymphocytopenia, leukocytosis, neutrophilia, thrombocytopenia (p<0.05). Biochemical parameters showed high CRP, increase in creatinine, decrease in glomerular filtration rate (p<0.05). A direct relationship was found between overweight and an increase in the content of C-RP in COVID-19 and PE patients. Conclusions: age over 65, hypertension and obesity are risk factors for severe course of COVID-19 and PE.
Lost Marie Curies: Parental Impact on the Probability of Becoming an Inventor
Authors: Hoisl Karin , Kongsted Hans Christian , Mariani Myriam
Published: May 2022

This research investigates the role of parents in explaining the surprisingly low presence of women among inventors despite their increase among graduates from science, technology, engineering and mathematics (STEM) subjects. With Danish registry data on the population born between 1966 and 1985 and an experimental setting crafted on siblings’ gender composition, we find that the transmission of inventorship from parents to children disfavors daughters if they have a (second-born) brother. We complement this analysis with evidence about the role of parental factors at different stages of children’s education. Overall, our results confirm that parental role models matter for children’s education, especially at early stages and, through this, increase the probability of a child’s becoming an inventor. However, the direct transmission of inventorship that favors boys much more than girls seems to be affected by gendered expectations developed by parents about daughters’ and sons’ returns from inventorship. Our study contributes to explaining who becomes an inventor and why by adding an important boundary condition to the literature: Parents are intermediaries who, based on their own interpretation of external information about inventive jobs, contribute to create or limit opportunities for their children.

This paper was accepted by Olav Sorenson, organizations.

Funding: The authors got financial funding from the Novo Nordisk Foundation in the course of the project “Investments, incentives, and the impact of Danish research (Triple-I-Research)” [Grant NNF16OC0021444].

Supplemental Material: Data files and the online appendix are available at https://doi.org/10.1287/mnsc.2022.4432 .
Public Opinion and Impression Management in the Communication of Performance During the Second Iraq War
Authors: Audia Pino G. , Rousseau Horacio E. , Stimmler Mary Kate
Published: May 2022

Although studies show that organizations engaged in controversial actions often aim to minimize the release of threatening information, scholars know relatively little about what may prompt organizations to increase transparency in these situations. In this study, we focus on support from public opinion as a condition that may influence the disclosure of sensitive performance information to the public. Using the second Iraq War as an empirical context, we focus on the extent to which public officials—Pentagon spokespersons—release and frame information about war performance. This outcome is critical because the way in which organizations communicate their performance to outsiders has often been regarded as a key defensive impression management tactic. We hypothesize that high public support for the war will increase the likelihood that Pentagon officials release information about sensitive combat performance indicators in their press briefings and identify contingencies, such as adversity and organizational spokespersons’ power, that moderate this relationship. We also explore whether high public support decreases the strategic use of alternate performance frames that emphasize metrics that signal progress toward a desirable end state. Using a unique data set based on the coding of press briefings, public opinion data, and other public sources, we find support for several of our hypotheses. We discuss implications for understanding the relationship between public opinion and impression management and highlight the importance of extending this research to nongovernmental organizations.

Supplemental Material: The online appendix is available at https://doi.org/10.1287/orsc.2022.1598 .
EDUKASI MENOPAUSE DAN ANDROPAUSE GUNA MEWUJUDKAN LANSIA SEHAT DAN PRODUKTIF DI KELURAHAN COKRODININGRATAN KECAMATAN JETIS YOGYAKARTA
Authors: Utami Fitriana Putri , Udin Rizaldy , Pratama Risqi Fitriyadi Rizal , Nugroho Aditya
Published: May 2022

Peningkatan Usia Harapan Hidup (UHH) diproyeksikan akan terus berlangsung, sehingga mengakibatkan peningkatan jumlah orang lanjut usia (lansia) pada masa mendatang. Masa lanjut usia ditandai dengan adanya menopause pada seorang wanita dan andropause pada pria. Masa ini sering disertai dengan adanya keluhan atau gangguan yang dapat mengganggu aktivitas sehari-hari. Keluhan-keluhan tersebut dapat diatasi dengan adanya persiapan fisik dan psikis menjelang lansia. Kegiatan pengabdian masyarakat ini bertujuan untuk memberikan informasi mengenai menopause dan andropause bagi lansia dan pra-lansia di RW 03, 04, dan 05 di Kelurahan Cokrodiningratan, Kec. Jetis, Kota Yogyakarta yang dilaksanakan selama tiga hari pada bulan November 2019, menggunakan metode penyuluhan dan tanya jawab.Â  Hasil dari kegiatan edukasi ini terlihat peserta kegiatan antusias dalam bertanya tentang materi yang disampaikan dan aktif menceritakan kisah mereka saat awal memasuki masa menopause dan andropause. Reaksi seseorang berupa suka atau tidak suka pada materi yang diterima merupakan faktor yang memegang peranan penting dalam pembentukan sikap akibat adanya kegiatan pendidikan dan pelatihan.
UPAYA PENCEGAHAN PENYAKIT YANG DISEBABKAN OLEH TIKUS DI RT 05 DAN 06 DUSUN PRINGGOLAYAN, BANGUNTAPAN BANTUL, D.I YOGYAKARTA
Authors: Parisudha Annisa Parisudha , Jannah Arihni Arihatal , Apriani Dewi , Puspitarini Elsa Nurdyah , Faatihah Utari Esi , Wijayanti Riana Dyah
Published: May 2022

Penyakit yang disebabkan oleh tikus menjadi kekhawatiran tersendiri di wilayah pemukiman penduduk heterogen dan juga padat. Upaya pencegahan dilakukan melalui program penyuluhan yang bertujuan untuk mengantisipasi terjadinya penyakit yang tidak diharapkan yang dapat dibawa oleh tikus. Metode program penyuluhan dilakukan melalui media banner yang berisikan kiat-kiat yang dapat dilakukan oleh masyarakat untuk mencegah terjadinya penyakit yang disebabkan oleh tikus. Dampak dari program yang dilakukan diketahui adanya kesadaran masyarakat yang muncul untuk berupaya menjalankan pesan-pesan yang tercantum didalam banner.Â Â
ASPEK KESELAMATAN DAN KESEHATAN KERJA PADA FASILITAS PELAYANAN KESEHATAN DI INSTANSI KESEHATAN WILAYAH KERJA PUSKESMAS BANGUNTAPAN III
Authors: Rifai Muchamad , Winanto Yokas Siswan , Maâ€™rifah Ulil , Asri Inaya Larang , Safitri Rizqi Nur Anis , Azmi Nur
Published: May 2022

Keselamatan dan kesehatan kerja di fasilitas pelayanan kesehatan merupakan salah satu upaya perlindungan terhadap tenaga kerja. Pada beberapa instansi kesehatan yang berada di wilayah kerja Puskesmas Banguntapan III, masih ditemukan beberapa permasalahan seperti penggunaan Alat Pelindung Diri (APD) dalam bekerja yang tidak lengkap serta tidak adanya media promosi keselamatan dan kesehatan kerja.Â  Masih kurangnya pengetahuan tentang pentingnya penerapan budaya keselamatan dan kesehatan kerja di beberapa instansi kesehatan membuat para pekerja tidak begitu memperhatikan aspek tersebut dan dapat menyebabkan terjadinya kecelakaan kerja. Untuk menanggulangi hal tersebut dilakukan intervensi ke beberapa instansi kesehatan. Tujuannya yaitu untuk meningkatkan pengetahuan pekerja tentang keselamatan dan kesehatan kerja di fasilitas pelayanan kesehatan, serta mengurangi risiko terjadinya kecelakaan kerja di tempat kerja. Metode yang digunakan yaitu pemberian Â media promosi keselamatan dan kesehatan kerja berupa poster dan leaflet, serta penyuluhan yang dilaksanakan dari tanggal 29 Januari sampai 27 Februari 2020. Hasil dari kegiatan tersebut yaitu pekerja menerima poster untuk dipasang di dinding dan leaflet untuk mereka baca, dan selainÂ  itu pekerja memiliki pengetahuan yang belum mereka ketahui sebelumnya tentang Keselamatan dan Kesehatan Kerja. Dampak program ini adalah pekerja telah sadar menggunakan APD dengan lengkap ketika bekerja.
PENINGKATAN PENGETAHUAN RUMAH SEHAT DENGAN METODE CERAMAH DAN LEAFLET DI DUSUN MODALAN
Authors: Sukesi Tri Wahyuni , Maurizka Isna Rahma , Pratiwi Ratih Dian , Kahar Mir Vindahati , Sari Dyah Ayu Puspita , Indriani Nur Safani , Santi Santi
Published: May 2022

Rumah merupakan lingkungan yang paling dekat masyarakat. Rumah yang tidak sehat dapat menimbulkan permasalahan-permasalahan kesehatan bagi penghuninya. Dusun Modalan Desa Banguntapan RT 8 dan RT 9 masih terdapat rumah yang belum memenuhi kriteria rumah sehat. Tujuan dari pengabdian kepada masyarakat ini adalah memberikan edukasi kepada masyarakat mengenai rumah sehat untuk meningkatkan kesehatan rumah sehingga penyakit berbasis lingkungan rumah dapat dikurangi. Metode yang digunakan dalam kegiatan penyuluhan pada pengabdian masyarakat ini yaitu dengan ceramah dan leaflet. Materi yang disajikan berkaitan dengan rumah sehat seperti indikator rumah sehat dan penyakit yang ditimbulkan bila rumah tidak sehat. Pembagian leaflet kepada peserta yang hadir pada saat intervensi terdiri dari tiga tema yaitu rumah sehat, sumber air bersih dan lima pilar Sanitasi Total Berbasis Masyarakat (STBM). Sasaran kegiatan pengabdian ini adalah warga masyarakat di Â Dusun Modalan. Kegiatan pengabdian kepada masyarakat berjalan dengan lancar, masyarakat memberikan respon yang positif terhadap kegiatan yang dilaksanakan. Masyarakat berpartisipasi aktif dalam setiap rangkaian kegiatan pengabdian kepada masyarakat ini.
UPAYA PEMBERDAYAAN PENINGKATAN RUMAH SEHAT DI DUSUN PRINGGOLAYAN KECAMATAN BANGUNTAPAN TAHUN 2020
Authors: Maulana Muchsin , Yuliana Deta , Listari Irma , Fadhila Nurul , Aulia Ranissa , Rahma Syfa Alifah , Hestiyani Teti
Published: May 2022

The house is a basic human need to live and as a means of interaction between fellow residents and even the environment. Community life of RT 04 and 07 Pringgolayan village are still very simple. So that it affects the awareness of environmental health, especially in managing and maintaining the hygiene of each resident's home. There are still many houses that do not open windows every day and there are wigglers in the bathtub. Therefore, further education is needed at the family level on how to keep the house healthy. The purpose of this activity is to provide education about the efforts that can be made to improve healthy homes. The method used is through counseling about efforts to improve healthy homes and by distributing leaflets to each resident's home. The target are PKK women RT 04 and 07 Pringgolayan village. When the activity is carried out, mothers can actively participate and capture the education that has been delivered. The impact obtained is that PKK women can increase knowledge and increase awareness to make their homes healthy.
Effects of Complex Korean Medicine Treatment on a Patient with Knee Pain and Ankylosis Following a Distal Femur Osteotomy: A Case Report
Authors: Park Han Bin , Heo Eun Sil , Yoo Dong Hwi , Jang Won Suk , Kwon Oh Bin , Choi Ki Won , Kwon Min Jin , Kim Tae Ju , Jang Seon Woo , Kwon Oh Hoon
Published: May 2022

Distal femur osteotomy (DFO) is a controlled surgical break of the femur performed to allow realignment of the limb. Redistribution of the load aims to correct the abnormal mechanical weight-bearing axes in patients with abnormal alignment of the lower extremities, and degenerative changes in the knee joint. This report describes a complex Korean medicine treatment for a patient complaining of knee pain and stiffness following a DFO. Post-operative care for the patient lasted 78 days with treatment including pharmacopuncture, acupuncture, herbal medicine, cupping therapy, and physiotherapy. The effectiveness of the treatments was evaluated using the numerical rating scale, range of motion of the knee, and by physical examination. After treatment, these evaluation indicators improved, suggesting that the complex Korean medicine treatment received by the patient was an appropriate treatment for knee pain and stiffness following a DFO.
Postsecondary Success Stories: Perspectives of Adults With Intellectual and Developmental Disabilities
Authors: Brendli Katherine R. , Kozachuk Lindsay
Published: May 2022

The Individuals With Disabilities Education Act (IDEA) of 2004 highlights the need for special education and related personnel to prepare youth with disabilities for adulthood, particularly in the areas of postsecondary education, employment, and independent living. In accordance with this policy, our study used qualitative case reporting to examine the personal perspectives of three adults with IDD in the outcome domains outlined by the IDEA. Using positive psychology and self-determination theories, we sought to better understand the diverse factors that contributed to the participants' “successes” in these areas. Results revealed a series of evidence-based predictors of success contributed to overcoming challenges to employment, postsecondary education, and independent living for participants. Implications for research, policy, and practice are discussed.
Multifunctional tunable visible light metalens based on double-layer barium titanate
Authors: Lv Shuyuan , Wang Rong , Luo Wenfeng , Bai Yuchi , Meng Fei
Published: May 2022

A tunable metalens plays an indispensable role in the development of integrated optics, multi-imaging systems, etc. We propose a multifunctional tunable metalens that combines a double-layer barium titanate (BTO) structure and geometric phase in the visible light band. The refractive indices of the upper and lower layer BTO nanorods can be tuned continuously and independently by applying external voltage (0–60 V), and the lower layer can be converted between a full-wave plate and normal scattering unit, while the scatterers of the upper layer can be switched between a half-wave plate and full-wave plate. The voltages of the upper and lower layers can be adjusted to achieve different functions such as optical switches, conversion between monofocal and bifocal metalenses, adjustment of bifocal intensity, and broadband focusing (585–690 nm). Simulation results show that the multifunctional tunable metalens has a good focusing effect. A metalens with high focusing efficiency, dynamic reconfigurability, and a switching function has tremendous application potential in the fields of multifunctional devices, biomedicine, optical communication, imaging, and so on.
Stress management using fNIRS and binaural beats stimulation
Authors: Al-Shargie Fares , Katmah Rateb , Tariq Usman , Babiloni Fabio , Al-Mughairbi Fadwa , Al-Nashash Hasan
Published: May 2022

In this study, we investigate the effectiveness of binaural beats stimulation (BBs) in enhancing cognitive vigilance and mitigating mental stress level at the workplace. We developed an experimental protocol under four cognitive conditions: high vigilance (HV), vigilance enhancement (VE), mental stress (MS) and stress mitigation (SM). The VE and SM conditions were achieved by listening to 16 Hz of BBs. We assessed the four cognitive conditions using salivary alpha-amylase, behavioral responses, and Functional Near-Infrared Spectroscopy (fNIRS). We quantified the vigilance and stress levels using the reaction time (RT) to stimuli, accuracy of detection, and the functional connectivity metrics of the fNIRS estimated by Phase Locking Values (PLV). We propose using the orthogonal minimum spanning tree (OMST) to determine the true connectivity network patterns of the PLV. Our results show that listening to 16-Hz BBs has significantly reduced the level of alpha amylase by 44%, reduced the RT to stimuli by 20% and increased the accuracy of target detection by 25%, (p < 0.001). The analysis of the connectivity network across the four different cognitive conditions revealed several statistically significant trends. Specifically, a significant increase in connectivity between the right and left dorsolateral prefrontal cortex (DLPFC) areas and left orbitofrontal cortex was found during the vigilance enhancement condition compared to the high vigilance. Likewise, similar patterns were found between the right and left DLPFC, orbitofrontal cortex, right ventrolateral prefrontal cortex (VLPFC) and right frontopolar PFC (prefrontal cortex) area during stress mitigation compared to mental stress. Furthermore, the connectivity network under stress condition alone showed significant connectivity increase between the VLPFC and DLPFC compared to other areas. The laterality index demonstrated left frontal laterality under high vigilance and VE conditions, and right DLPFC and left frontopolar PFC while under mental stress. Overall, our results showed that BBs can be used for vigilance enhancement and stress mitigation.
Non-invasive visualization of amyloid-beta deposits in Alzheimer amyloidosis mice using magnetic resonance imaging and fluorescence molecular tomography
Authors: Ren Wuwei , Li Linlin , Zhang Jianru , Vaas Markus , Klohs Jan , Ripoll Jorge , Wolf Martin , Ni Ruiqing , Rudin Markus
Published: May 2022

Abnormal cerebral accumulation of amyloid-beta peptide (Aβ) is a major hallmark of Alzheimer’s disease. Non-invasive monitoring of Aβ deposits enables assessing the disease burden in patients and animal models mimicking aspects of the human disease as well as evaluating the efficacy of Aβ-modulating therapies. Previous in vivo assessments of plaque load have been predominantly based on macroscopic fluorescence reflectance imaging (FRI) and confocal or two-photon microscopy using Aβ-specific imaging agents. However, the former method lacks depth resolution, whereas the latter is restricted by the limited field of view preventing a full coverage of the large brain region. Here, we utilized a fluorescence molecular tomography (FMT)-magnetic resonance imaging (MRI) pipeline with the curcumin derivative fluorescent probe CRANAD-2 to achieve full 3D brain coverage for detecting Aβ accumulation in the arcAβ mouse model of cerebral amyloidosis. A homebuilt FMT system was used for data acquisition, whereas a customized software platform enabled the integration of MRI-derived anatomical information as prior information for FMT image reconstruction. The results obtained from the FMT-MRI study were compared to those from conventional planar FRI recorded under similar physiological conditions, yielding comparable time courses of the fluorescence intensity following intravenous injection of CRANAD-2 in a region-of-interest comprising the brain. In conclusion, we have demonstrated the feasibility of visualizing Aβ deposition in 3D using a multimodal FMT-MRI strategy. This hybrid imaging method provides complementary anatomical, physiological and molecular information, thereby enabling the detailed characterization of the disease status in arcAβ mouse models, which can also facilitate monitoring the efficacy of putative treatments targeting Aβ.
Numerical simulation of optical refractometric sensing of multiple disease markers based on lab-in-a-fiber
Authors: Zheng Zhou , Li Zhengying , Du Qingguo
Published: May 2022

A multi-parameter optical refractometric sensor based on lab-in-a-fiber is proposed and its sensing properties have been investigated. Based on the particular three suspended-core fiber, the sensor has three channels for liquid circulation and three suspended cores for detection. The multiple disease markers can be detected by coating the specific bio-recognition layer on the surface of three channels. The bio-recognition layer thickness, representing the concentration of the disease markers, can then be measured by the wavelength of fiber Bragg grating inscribed in each suspended core. Owing to the triple symmetry of the fiber, the sensitivity of each core is similar. The simulation results show that the grating wavelength linearly changes with the bio-recognition layer thickness variation. Through the sensitivity matrix, the sensitivity of the sensor is 0.362 nm/nm and the sensing accuracy is ± 1 nm.
2m-distance external cavity VECSEL for wireless charging applications
Authors: Zhang Zhuo , Zhang Jianwei , Zhou Yinli , Zhang Xing , Li Zhiwei , Zhang Jiye , Zhang Jun , Gong Yuxiang , Liu Tianjiao , Mu Jingfei , Ning Yongqiang , Qin Li , Wang Lijun
Published: May 2022

We characterize laser generation in an ultralong air cavity (several meters in length) using an optical-pumped semiconductor gain chip for laser wireless charging applications. The study realizes laser generation in an external air cavity with a length of 200 cm, for the first time, and achieves a maximum output laser power of more than 86.3 mW. Furthermore, the laser oscillation can be maintained even when the output mirror of laser is off-axis within 1.6 cm. Thus, a long external cavity laser would ease the alignment between the laser beam and charging terminal, making it suitable for laser wireless charging applications.
Block compressive sensing chaotic embedded encryption for MCF-OFDM transmission system
Authors: Zhong Qing , Guo Zhiruo , Liu Bo , Ren Jianxin , Mao Yaya , Wu Xiangyu , Wu Yongfeng , Zhao Lilong , Sun Tingting , Ullah Rahat
Published: May 2022

In this paper, we propose a block compressive sensing (BCS) based chaotic embedded encryption scheme for multi-core fiber orthogonal frequency division multiplexing (MCF-OFDM) system. BCS technology is used to recover the entire desired information from the small amounts of data. Meanwhile, a four-dimensional discrete chaotic encryption model generates four masking factors, which are respectively used for coefficient random permutation (CRP), measurement matrix, diffusion and singular value decomposition (SVD) embedding to achieve ultra-high security encryption of four different dimensions. In terms of compressive sensing, CRP can make the discrete cosine transform (DCT) coefficient distribute randomly to improve the sampling efficiency of BCS. Compared with the data without compressive sensing, the data volume is reduced by 75%. In chaotic encryption, SVD technology embeds secret images of noise-like after initial encryption into carrier images to generate encrypted images with visual security. The key space reaches 10120 and it realizes the dual protection of source image data and external representation. The proposed scheme using a 2km 7-core optical fiber achieves a 78.75 Gb/s transmission of encrypted OFDM signals. The received optical power is greater than -14 dBm, and the bit error rate (BER) of core1-core7 is lower than 10−3. When the compression ratio sets to 0.25 and the attack range of encrypted data is up to 30%, the image can still recover the outline and general information. The experimental results show that this scheme can improve the security performance and reduce the complexity of information transmission system. Furthermore, the scheme combines The BCS chaotic embedded encryption technology with MCF-OFDM system, which has a good application prospect in the future optical networks.
Programmable high-order mode control method based on acoustically induced fiber grating
Authors: Wu Haocun , Xu Jiangtao , Zhu Yi , Zeng Xianglong
Published: May 2022

We demonstrate a programmable high-order mode control method that can be implemented in high-power fiber lasers. 2 W average-power mode-locked pulses are obtained based on a mode-locked fiber laser working in dissipative soliton resonance regime. The fundamental mode (LP01) is fully or partially converted to the high-order modes (LP11a/b) via an acoustically-induced fiber grating. The mode-superposition fields are recorded using an optical 4f system, and mode components are subsequently analyzed by a mode decomposition algorithm. Our experiments suggest that the mode patterns are stable and dynamically switchable. The method is expected to possess good application value in optical tweezers, fiber communication, laser material processing and other research fields.
Bistable reflection and beam shifts with excitation of surface plasmons in a saturable absorbing medium
Authors: Cai Yuan-Ping , Wan Ren-Gang
Published: May 2022

We investigate the nonlinear reflection of a light beam from a Kretschmann configuration with saturable absorbing medium. The absorption of medium has direct influence on the intrinsic loss of the system, thus affecting the reflectivity and the phase variation when the surface plasmons are resonantly excited. As the incident power changes, the reflectivity can be switched between high and low values and exhibits absorptive optical bistability as a result of the inherent positive feedback by the intensity-dependent saturation effect. The Goos-Hänchen and the Imbert-Fedorov shifts of the reflected beam have the same bistable behavior as the reflectance. The effects of the thickness of metal film and the linear absorption coefficient on the hysteresis loop are analyzed in detail by considering the system losses and the saturated absorption. The bistable reflection and beam shifts may have applications in all-optical devices, such as optical switching.
Tapered self-written waveguide for a silicon photonic chip I/O
Authors: Saito Yohei , Shikama Kota , Tsuchizawa Tai , Sato Norio
Published: May 2022

An optical coupling method with high alignment tolerance by self-written waveguide (SWW) formation is a promising candidate for co-packaged optics (CPO) by silicon photonics (SiPh). However, conventional SWWs cannot be used with Si waveguides because visible light for SWW formation cannot radiate from the waveguide facet. Here, we devised a new, to the best of our knowledge, optical circuit with SiOxNy waveguides for SWW formation from an SiPh chip. With our circuit, we achieved optical coupling between an SiPh chip and a standard single-mode fiber (SSMF) with a tapered SWW (TSWW). The lowest excess coupling loss compared to butt coupling with a high-numerical aperture (NA) fiber is approximately 0.6 dB over the C-band with the TSWW. In addition, our coupling method has higher alignment tolerances than butt coupling with a high-NA fiber (HNF).
Ultra-compact diode-pumped single-frequency Ti:sapphire laser
Authors: Lagatsky Alexander A. , Bonner Gerald M. , Schlosser Peter J. , Stothard David J. M. , McKnight Loyd J.
Published: May 2022

In this Letter, we report on the development of an ultra-compact
single-frequency Ti:sapphire laser under direct diode pumping.
Single-longitudinal-mode operation is realized from a miniature
plane-parallel resonator using a volume Bragg grating as an output
coupler. InGaN laser diodes operating at around 470 nm and 490 nm with
a combined power of 6.7 W are used as an optical pump. A maximum
output power of 700 mW is generated during single-frequency operation
at 813.4 nm. A laser linewidth of 2.4 MHz is measured during
free-running operation, which is reduced to about 180 kHz when the
laser is locked to an external reference cavity.
Cascaded Raman amplifiers based on fluorotellurite fibers
Authors: Jiao Yadong , Meng Fanchao , Jia Zhixu , Guo Qi , Yu Yongsen , Zheng Chuantao , Ohishi Yasutake , Qin Weiping , Qin Guanshi
Published: May 2022

In this letter, we demonstrate efficient cascaded Raman amplification in fluorotellurite fibers pumped by a 1550 nm nanosecond laser. All-solid fluorotellurite fibers with a core diameter of ∼ 5 µm are fabricated by using a rod-in-tube method. By using a continuous wave (CW) 1765 nm fiber laser as the signal source for first-order Raman amplification, the amplified 1765 nm laser with an average output power of ∼ 190.9 mW and a pulse width of ∼ 3.42 ns is obtained from a 3 m long fluorotellurite fiber for an average pump power of ∼ 519.35 mW and an input signal power of ∼ 1.05 mW, corresponding to a net gain of ∼ 22.6 dB and an optical-to-optical conversion efficiency of 36.76%. Furthermore, a CW 2049.2 nm fiber laser combined with the above 1765 nm laser are used as the signal sources for second-order cascaded Raman amplification. As the power of the 1765 nm and 2049.2 nm lasers are set as 1.05 and 1.00 mW, respectively, the amplified 2049.2 nm laser with an average output power of ∼ 135.35 mW and a pulse width of ∼ 3.36 ns is obtained from the fluorotellurite fiber for an average pump power of ∼ 558.37 mW, corresponding to a net gain of ∼ 21.3 dB and an optical-to-optical conversion efficiency of 24.24%. As the length of the fluorotellurite fiber is increased to 10 m, third-order cascaded Raman amplification is observed by using a 2442.6 nm signal generated by four-wave mixing and the above 1765/2049.2 nm lasers as the signal sources, causing the generation of the amplified 2442.6 nm laser with an average output power of ∼ 18.84 mW. Our results show that fluorotellurite fibers are promising gain media for constructing cascaded Raman fiber amplifiers with a wide range of wavelengths.
Diet-responsive transcriptional regulation of insulin in a single neuron controls systemic metabolism
Authors: Handley Ava , Wu Qiuli , Sherry Tessa , Cornell Rebecca , Pocock Roger
Published: May 2022

Metabolic homeostasis is coordinated through a robust network of signaling pathways acting across all tissues. A key part of this network is insulin-like signaling, which is fundamental for surviving glucose stress. Here, we show that Caenorhabditis elegans fed excess dietary glucose reduce insulin-1 (INS-1) expression specifically in the BAG glutamatergic sensory neurons. We demonstrate that INS-1 expression in the BAG neurons is directly controlled by the transcription factor ETS-5, which is also down-regulated by glucose. We further find that INS-1 acts exclusively from the BAG neurons, and not other INS-1-expressing neurons, to systemically inhibit fat storage via the insulin-like receptor DAF-2. Together, these findings reveal an intertissue regulatory pathway where regulation of insulin expression in a specific neuron controls systemic metabolism in response to excess dietary glucose.
Implementation of E-exams during the COVID-19 pandemic: A quantitative study in higher education
Authors: Eltahir Mohd. Elmagzoub , Alsalhi Najeh Rajeh , Al-Qatawneh Sami Sulieman
Published: May 2022

The primary aim of this study was to identify the degree of acceptance of e-exams by undergraduate students at Ajman University during the spread of the COVID-19 pandemic. The study used the descriptive approach. A questionnaire consisting of 27 items was distributed to 1986 undergraduate students. The results of the study showed that undergraduate students demonstrated a moderate degree of acceptance of the implementation of e-exams during the spread of the COVID-19 pandemic, with females students finding them more acceptable than male students. Discipline and academic year also showed an impact on such acceptance, with Pharmacy & Health Science College students, and those in their third academic year demonstrating the highest levels of acceptance. Implications of the study raise awareness of the importance of addressing challenges associated with e-exams such as strict computer technology settings.