bluuebunny/crossref_metadata_2025 huggingface dataset:
Exemption from serving a sentence with probation of a person who committed bribery, in case of concluding agreements in criminal proceedings
Authors: Bilokon O. G.
Published: December 2022

The article is devoted to the study of the problem of release from probation of a person who has committed a corruption criminal offense, including bribery, in the case of entering into agreements in criminal proceedings (reconciliation agreements and plea agreements). Analyzed. two different approaches that exist today in the theory of criminal law and in law enforcement practice regarding the possibility / impossibility of release from serving a sentence with probation of a person who committed a corruption criminal offense, based on part 2 of Article 75 of the Criminal Code of Ukraine.

The first approach is that determining the content of Part 2 of Article 75 of the Criminal Code of Ukraine should be done, first, by establishing its systemic connections with the provisions of Part 1 of this article. In addition, scientists suggest that the provisions of Part 2 of Article 75 of the Criminal Code of Ukraine should be systematically interpreted also with other provisions of this Code, in particular with the provisions of Art. 69 of the Criminal Code of Ukraine, part 1 of which contains a prohibition on the imposition of a lighter punishment than that prescribed by law for committing corruption offenses without any restrictions, that is, even in the case of concluding a corresponding agreement. The opposite interpretation, according to supporters of the first approach, indicates a violation of the systematic way of interpreting legal norms.

Scientists who adhere to a different approach note that parts 1 and 2 of Article 75 of the Criminal Code of Ukraine should be interpreted separately. At the same time, they note that part 2 of Article 75 of the Criminal Code of Ukraine does not directly prohibit exemption from serving a sentence with probation for committing corruption crimes based on plea agreements for corruption crimes. In the opinion of these scientists, the refusal of a person convicted of a crime provided for in the footnote of Article 45 of the Criminal Code of Ukraine to be released from serving a sentence based on part 2 of Article 75 of the Criminal Code of Ukraine can be legal only if appropriate changes are made to the legislation. This approach is also followed in the judicial practice of the High Anti-Corruption Court.

The article actually supports the second of the above approaches and substantiates it, in particular, by different adjustments to parts 1 and 2 of Article 75 of the Criminal Code of Ukraine, the legal nature of the criminal procedural compromise. Arguments are given in favor of distinguishing a new type of agreement in criminal proceedings in the Criminal Procedure Code of Ukraine - an agreement on cooperation.

In order to avoid different approaches, it is proposed to amend Part 2 of Article 75 of the Criminal Code of Ukraine.

Key words: bribery, corruption criminal offense, release from sentence with probation, plea agreement, settlement agreement.
According to the publicity of the bank deposit agreement under the civil legislation of Ukrainе
Authors: D’yachenko T.
Published: December 2022

The statute extends the power of civil legislation to a bank deposit agreement, for the participation of physical assets, as a public agreement. The indications are considered by the author as one of the applications of the exchange on the principle of «freedom of contract» in the civil circulation of Ukraine, which is directed at the defense of the weak side of the civil contract, which is a physical person who places the contract of a bank deposit with the bank. On the basis of the scientific research carried out by the author, the author states for such banks the right to entitle the depositor - an individual in the bank deposit agreement laid down in the bank deposit agreement, as well as the specificity of the parties to the bank deposit agreement, in which the depositor is an individual, vimg part 2. 633 Central Committee of Ukraine. The author has established that banks have laid down agreements on bank deposits with physical persons, like “great investors”, for the model of the agreement, with additions, they could have part 2 of article 633 of the Central Committee of Ukraine, є complicate It is pointed out that it is practically impossible to standardize the mind of a bank deposit agreement for such companies, looking at those who are able to agree on a bank deposit, from the side of potential depositors can be different. In general, there are also hybrid agreements on bank deposits for the participation of physical assets, for example, received by the bank on the minds of a subordinate board.

The aim of the article. Based on a comprehensive analysis of civil law of Ukraine, to investigate the legal regulation of the bank deposit agreement, under which the depositor is an individual, as a public contract, to investigate the requirements of the law to such agreements, and provide suggestions for improving existing civil law. Results. Taking into account the above, we can conclude that under the conditions of expediency of maintaining the publicity of the bank deposit agreement, with the participation of individuals, at the level of Part 2 of Art. 158 of the Civil Code of Ukraine, it is advisable to give the right to the National Bank of Ukraine to determine the bank deposit agreements in which the depositor is an individual, such as the rules of Part 2 of Art. 633 of the Civil Code of Ukraine do not apply.

Key words: deposit, agreement, bank deposit agreement, public agreement, admission agreement, pennies, goiter, subordination borg.
The right to life and the right to health: the fundamental principles of transplantology in constitutional law
Authors: Chornenka D. S.
Published: December 2022

The article examines basic human rights. Among the fundamental and inalienable human rights is the right to life. Yes, Art. 27 of the Constitution of Ukraine guarantees everyone an inalienable right to life. It states that no one can be arbitrarily deprived of life. The duty of the state is to protect human life. This right is closely related to human health. It is emphasized that human life depends on the state of its health. Often health is a major component for conservation and prolonged life. Accordingly, organ transplantation, as a way of saving life, is especially important, and therefore the problems of transplanting organs and tissues are drawn by scientists, and not only from the medical sphere.

Transplantation of organs and tissues of the human body is one of the most promising and at the same time quite in demand of modern medicine, which has made it possible to treat a number of serious diseases. Transplantation of organs and tissues, as a means of real assistance to patients who need it, has a number of characteristic features that distinguish this method from other medicinal effects. This is due to the presence of a donor-a person who in most cases does not require medical care, as well as problems of moral and ethical and general legal content. These circumstances substantiate the importance and need to regulate public relations in the field of transplantology. It is emphasized that the analysis of the norms in force in this area shows that many issues of transplantation of organs and tissues are either not regulated at all or need to improve legal regulation. The legal aspects of the problem of organ and tissue transplantation are extremely relevant. That is why transplantology as a science of transplanting organs and (or) tissues of a person should be based on the law, which is based on the protection of fundamental rights, freedoms and human dignity of every citizen. From the point of view of ethics, the problem of transplantology differs significantly depending on whether it is about the sampling of organs and tissues for transplanting organs in a living person or from the body of the dead. Solving these ethical problems depends largely on the state of legislation in the state, including constitutional ones.

Key words: human rights, right to life, right to health, somatic rights, transplantation, recipient, donor, legal regulation of donation, health care, human body, human body tissues.
The Organizational Development Strategy of a Waste Bank at Bank Sampah Regensi by Using SWOT Analysis
Authors: Yulian Lutfi , Yandri Pitri
Published: December 2022

Waste is still one of the factors of environmental pollution. The rate of increase in waste every year increases without the addition of TPS. Along with the confirmation of the Corona virus and many community activities are done from home, such as shopping and online selling activities. Without realizing it, these activities cause new waste, such as tape, bubble wrap, and plastic wrap. Waste reduction and management can be done through waste banks. As in Cisoka Indah Regensi Housing, there is a Bank Sampah Regensi. The Bank Sampah Regensi is run by teenagers in RT.03 RW.06. Where their average age is still a student. This study aims to identify the weaknesses, strengths, opportunities and threats of the Bank Sampah Regensi and provide recommendations for the best strategies that the Bank Sampah Regensi can take for the development of the Bank Sampah Regensi organization. This research is a qualitative descriptive research with descriptive analysis techniques and quantitative SWOT of IFAS and EFAS. The sampling technique uses purposive sampling. The results of this study show that the Regence Waste Bank is in quadrant I, meaning that the organization is in a strong position and has the opportunity. The recommended strategy is to support aggressive policies (growth oriented strategy), namely: sensitivity training, team building, and management by objective. As well as the Strenghts-Opportunity strategy and the Weakness-Opportunity strategy.
Choice of an experimental model and modeling method in the study of the pathogenesis and methods of treatment of age-related macular degeneration (review)
Authors: Khodzhaev N. S. , Chuprov A. D. , Kim S. M. , Stadnikov A. A.
Published: December 2022

Background. Experimental modeling of various pathological processes in the organ of vision is an integral part of both fundamental and applied research. For a deeper understanding of the pathogenesis of age-related macular degeneration (AMD) and testing of new methods of its treatment, various experimental models of AMD in animals have been developed. However, at the stage of setting up the experiment, each researcher faces the difficult task of choosing an adequate animal model that has the closest homology with human anatomy and pathology, as well as a method for modeling it.

Purpose. To analyze the literature data concerning the choice of AMD experimental model and methods for its modeling, to assess the advantages and limitations of their use in the study of the pathogenesis and effectiveness of modern methods for treating this ophthalmopathology.

Materials and methods. The analysis of publications on PubMed, eLibrary, Cyberleninka resources for the period from 2000 year to the present has been carried out.

Results. The review considers the criteria for selecting experimental models and groups of animals most often used as an object of study (mice, rats, rabbits, pigs and primates). Among the methods for AMD modeling, chemically induced methods (using sodium iodate, N-methyl-N-nitrosourea and cobalt chloride), as well as physically induced methods (mechanical and light damage to reti na) were analyzed.

Conclusion. The use of rabbits as an object of study, even though the macular area is absent, is a well-established model of AMD, in view of the fact that the structure of their reti na corresponds to the general structure of the mammalian retina in areas of greatest visual acuity. Light-induced retinal damage occupies a leading position among AMD modeling methods, which is characterized by a number of advantages – control of the time and intensity of exposure to obtain the required degree of degeneration. The information presented in this review will allow researchers to choose the most adequate model among experimental animals and a method for modeling AMD.
Обзор научных публикаций
Authors: Editorial Article
Published: December 2022

Цифровизация общества, начало которой положено в середине прошлого века, оказывает свое влияние на орган зрения, увеличивая нагрузку на мышечно-аккомодационный аппарат, изменяет глазную поверхность. Комплекс симптомов, возникающих при работе с экранами, выделен в отдельную нозологию – «компьютерный зрительный синдром». Количество научных публикаций на эту тему увеличивается с каждым годом. В данном обзоре приведены резюме статей, отражающие такие исследования. Используя ссылку DOI, вы можете ознакомиться с полными текстами этих работ.
Alat Kendali Kelembaban pada Budidaya Jamur Tiram di Pondok Pesantren Darussalam
Authors: Dewatama Denda , Fauziyah Mila , Fauziyah Mila , Priyadi Bambang , Hariyadi Herman , Komarudin Achmad , Adhisuwignjo Supriatna
Published: December 2022

Yayasan Pendidikan Islam (YAPSI) Darussalam merupakan salah satu lembaga pendidikan yang menaugi Pondok Pesantren (PP) Darussalam yang berasa di desa Jatiguwi Kecamatan Sumber Puncung Kabupaten Malang. PP Darussalam merupakan pondok pesantren yang menaungi santri usia sekolah yang berasal dari keluarga prasejahtera mulai dari tingkat SD-SMP. Selain fokus pada pendidikan sekolah formal santri pada PP Darussalam juga dibekali dengan pelajaran keagamaan Islam dan kewirausahaan untuk membekali dan membantu perekonomian para santri. Salah satu bidang kewirausahaan yang dikembangkan untuk ketahanan ekonomi santri adalah usaha dibidang pembudidayaan jamur tiram. PP Darussalam mempunyai kumbung jamur seluas 4m x 4m dengan kapasitas 500 baglog, dengan hasil 2kg/hari. Hal ini bisa dibilang tingkat keberhasilannya kecil karena seharusnya bisa mendapatkan 4-6kg/hari, selain itu kapasitas masih bisa ditingkatkan sampai dengan 1000 baglog. Hasil analisa dari tim pelaksana PKM dan pihak pesantren menyebutkan kegagalan dalam budidaya jamur tiram disebabkan karena perawatan kumbung jamur tidak maksimal karena semua dilakukan secara manual.Oleh karena itu dibutuhkan alat otomasi kendali kelembaban pada budidaya jamur tiram. Alat yang dibuat mempunyai empat (4) mode yaitu:1 mode full otomatis dan 3 mode semi otomatis. Mode-mode yang dibuat agar alat dapat bekerja sesuai dengan perubahan kondisi lingkungan yang berbeda. Selain menghibahkan alat, pelaksanaan PKM ini juga memberikan pelatihan kepada pengelola pondok berupa pelatihan pengoperasian dan perawatan sederhana alat yang dihibahkan.
Analisis Pemanfaatan Smart PJU Panel Surya di Desa Banjarejo – Pakis – Kab.Malang
Authors: Imron Ridzki  , Budi Eko Prasetyo  , Chandra Wiharya  , Asfari Hariz Santoso  , Lukman Hakim
Published: December 2022

Energi surya memiliki kemampuan untuk menghasilkan listrik dengan biaya bahan bakar yang dapat diabaikan, tidak menyebabkan polusi dan tidak ada risiko adanya lonjakan harga bahan bakar. Penggunaan energi surya sebagai sumber energi listrik salah satunya adalah untuk penerangan jalan umum. Pemanfaatan panel surya sebagai smart street lighting di desa banjarejo dusun Ngamprong RT.02 RW.04 Kecamatan Pakis Kabupaten Malang didasari kondisi bahwa pemasangan lampu penerangan jalan masih bersifat individu masyarakat yang bersedia memberikan sambungan listrik untuk penerangan jalan. Selain itu sering kali dalam menyalakan dan memadamkan lampu penerangan jalan mengalami keterlambatan. Dari hasil analisis maka didapatkan penghematan energi listrik sebesar 21.6 kWh untuk model 1 dan 14.04 kWh untuk model 2 di setiap 30 harinya. Model 2 dalah model yang paling hemat, sehingga setting yang digunakan dalah setting model 2.
Sosialisasi Motivasi Berwirausaha Bagi Ibu-Ibu PKK RW 20 Kelurahan Bunulrejo Kota Malang
Authors: Lilies Nur Aini  , Sanita Dhakirah  , Ayu Febrianti Puspitasari  , Suci Nurfauziah  , Ane Fany Novitasari
Published: December 2022

Kontribusi perempuan dalam mensejahterakan kehidupan keluarga sangat besar, selain menjadi pengelola urusan rumah tangga, perempuan juga dituntut untuk membantu dalam mencari nafkah demi mencukupi kehidupan sehari-hari yaitu dengan cara berwirausaha. Jiwa wirausaha perlu untuk ditumbuhkan dengan dengan dorongan motivasi berwirausaha yang baik. Sasaran yang akan dituju dalam pengabdian masyarakat kali ini adalah Ibu-ibu PKK RW 20 Kelurahan Bunulrejo Kota Malang. Ibu-ibu PKK sebenarnya merupakan salah satu aset yang dimiliki di dalam keluarga khususnya dan di wilayah kampung pada umumnya dan secara mayoritas usia ibu-ibu PKK yang ada merupakan usia produktif. Akan tetapi mereka belumlah memiliki bekal yang cukup dalam rangka memajukan kampungnya, karena skill, pengalaman dalam bekerja mereka masih sangat minim Tujuan dari pengabdian ini adalah memberikan dorongan motivasi kepada ibu-ibu PKK untuk berwirausaha, Hasil luaran pengabdian ini diharapkan agar ibu-ibu PKK dapat meningkatkan motivasi untuk memulai usaha. Hasil evaluasi kegiatan pengabdian menunjukkan tercapainya target kegiatan yang meliputi keberhasilan target jumlah peserta pelatihan, ketercapaian tujuan sosialisasi, ketercapaian target materi serta kemampuan peserta dalam penguasaan materi. Kegiatan ini mendapatkan sambutan dan antusiasme yang baik terbukti dengan keaktifan peserta dalam berpartisipasi selama kegiatan berlangsung.
Pelatihan Instalasi Dan Penataan Sistem Tata Suara Bagi Mushola Al-Khoir, Di RT 01/ RW 09, Desa Tegalweru, Kecamatan Dau, Kabupaten Malang
Authors: Fakhruddin Muhammad , Mashudi Imam , Muzaki Mochamad , Wicaksono Hangga , Pramita Sari Nurlia , Pranoto Bayu
Published: December 2022

Indonesia merupakan negara muslim terbesar di dunia, dengan jumlah 264 juta penduduk yang tersebar di berbagai pulau. Dengan mayoritas penduduk Indonesia yang beragama muslim maka jumlah tempat peribadatan atau masjid dan mushola jumlahnya sebanding dengan penduduknya. Saat ini terdapat sekitar 250 ribu masjid dan 550 ribu mushola. Namun dari jumlah tersebut tercatat ribuan masjid masih mempunyai peralatan dan penataan sistem tata suara yang buruk. Mushola Al-Khoir yang terletak di Desa Tegalweru, Kecamatan Dau, Kabupaten Malang memiliki system tata suara yang kurang baik, padahal system tersebut harus rutin digunakan untuk kegiatan Mushola Al-Khoir sehari-hari, seperti mengumandangkan adzan, memberikan pengumuman terkait dengan kegiatan sosial, pengajian, dan sebagainya. Pada pengabdian ini diusulkan pelatihan instalasi dan penataan sistem tata suara di Mushola Al-Khoir, Desa Tegalweru, Kecamatan Dau, Kabupaten Malang. Diharapkan dengan adanya pelatihan dan penataan sistem tata suara ini kualitas suara yang dihasilkan semakin bagus sehingga membuat nyaman masyarakat yang ingin beribadah. Selain itu, dengan adanya pelatihan ini diharapkan ketika system tata suara rusak, pengurus mushola dapat memperbaikinya sendiri.
Pembuatan Sarana Papan Nama Dan Petunjuk Arah Menuju Kerajinan Anyaman Bambu Di Desa Duwet Kecamatan Tumpang Kabupaten Malang
Authors: Kadek Suarjuna Batubulan  , Putra Prima Arhandi  , Annisa Taufika Firdausi  , Vipkas Al Hadid Firdaus  , Ade Ismail  , Rizky Ardiansyah
Published: December 2022

Desa Duwet Krajan merupakan Desa yang terletak dikaki gunung tengger, terbagi atas tiga dusun, Swaru paling bawah, Krajan dan Dusun Tosari, Desa Duwet Krajan berbatasan timur dengan TNBTS sebelah selatan berbatasan dengan Kecamatan Poncokusumo sedangkan paling barat berbatasan dengan Desa Tulus Besar Kecamatan Tumpang utara berbatsana dengan Desa Duwet Kecamatan Tumpang. Untuk dapat menuju ke desa Duwet tersebut dari jalan utama membutuhkan jarak sekitar kurang lebih 4 kilometer dan itupun banyak sekali tikungan dan simpangan sehingga dapat membuat pengunjung tersesat. Dari hasil observsi banyak sekali pengunjung yang tidak tahu arah untuk menuju ke lokasi desa tersebut sehingga pengabdian ini akan membuatkan papan nama dan penunjuk arah yang akan memudahkan bagi pengunjung. Hasil yang diharapkan bagi masyarakat yang ingin berkunjung ke desa bambu duwet untuk membeli anyaman bambu dapat mengikuti papan penunjuk arah tersebut dan tidak tersesat untuk menuju lokasi tersebut. Didalam pengujian kepuasan pelanggan tersebut dapat dilihat bahwa 98% pengabdian ini bermanfaat dan 2% masih belum memutuskan karena ada yang tidak sesuai tulisan didalam penunjuk arah sebab ada huruf yang salah tetapi tidak lama kemudian tim pengabdian merevisi dari hasil yang diinginkan.
Reflection Habituation on The Online Tutorial
Authors: Mestika Sekarwinahyu  , Amalia Sapriati  , Ucu Rahayu
Published: December 2022

This study aims to produce a reflective learning program that can be applied to the online tutorial for the final project to improve students' reflective thinking skills. Through a series of phased activities, a reflective learning program using discussion as the core of activities followed by reflection activities using the Gibbs’ reflective cycle has produced a reflective learning program in an online tutorial that is ready to be tested. The test was conducted to measure the students' reflective thinking level before and after using the program using the Kember reflective thinking level instrument. The study show that the program has the main characteristic of sharpening students' reflective thinking skills.  After using the program, students' reflective thinking skills showed an increase in the highest score at the critical reflection level. The program has the advantage that students will get used to doing reflection and can practice higher-order thinking skills through discussion activities. Program limitations occurred because of the effect of program characteristics, namely, students must have high motivation, discipline, and independent learning, students must have sufficient computer and IT skill.  The program has the potential to increase the ability of reflection to support a change/shift towards a higher level of reflective thinking.
Hubungan Perilaku Ibu dalam Pemberian Asi Eksklusif dan Pemberian MP-ASI terhadap Kejadian Stunting di Kelurahan Naioni Kota Kupang
Authors: Rifandy Muhammad Rifqy , Nur Marselinus Laga , Riwu Rut Rosina
Published: December 2022

Stunting merupakan kondisi kronis yang menggambarkan terhambatnya pertumbuhan karena malnutrisi jangka panjang yang ditandai dengan indeks panjang badan dibanding umur (PB/U) atau tinggi badan dibanding umur (TB/U) dengan batas z-score kurang dari -2 SD. Kejadian stunting pada balita disebabkan karena perilaku ibu yang kurang baik. Penelitian ini bertujuan untuk menganalisis perilaku ibu dalam halnya pengetahuan, sikap dan tindakan dalam pemberian ASI eksklusif dan MP-ASI terhadap kejadian stunting di Kelurahan Naioni Kota Kupang. Jenis penelitian yang digunakan adalah observasi analitik dengan rancangan case control­. Sampel dalam penelitian ini sebanyak 60 ibu yang memiliki anak balita yang dibagi menjadi 30 untuk balita stunting dan 30 untuk balita normal di Kelurahan Naioni Kota Kupang. Analisis data yang digunakan adalah analisis univariabel dan analisis bivariabel, dengan uji statistik chi-square. Hasil penelitian ini menunjukkan bahwa faktor yang berpengaruh terhadap kejadian stunting adalah pengetahuan ASI eksklusif p=0,041, OR=4,333, sikap pemberian ASI p=0,000, OR=18,000, tindakan pemberian ASI p=0,000, OR=13,143, pengetahuan MP-ASI p=0,003, OR=10,706, sikap pemberian MP-ASI p=0,000, OR= 11,667 dan tindakan pemberian MP-ASI p=0,002, OR= 6,417. Kesimpulan dari penelitian ini adalah stunting berhubungan dengan perilaku ibu dalam pemberian ASI dan pemberian MP-ASI di Kelurahan Naioni Kota Kupang
Pengaruh Suhu Penyimpanan Terhadap Jumlah Eritrosit Pada Transfusi Darah di Rumah Sakit Bank Darah RSUD Dr. Soedarso Pontianak
Authors: Sri Tumpuk  , Laila Kamilla  , Linda Triana
Published: December 2022

Transfusi adalah proses pemindahan darah dari donatur kepada resipien, guna memperbaiki kondisi anemia dengan menggunakan darah yang berkualitas baik. Darah sebelum didonasikan akan disimpan pada refrigerator. Pada penyimpanan, darah akan mengalami berbagai perubahan komponen, termasuk jumlah trombosit, jumlah eritrosit dan kadar hemoglobin. Penyimpanan PRC didalam blood bank dengan suhu standar 10C - 60C mengurangi lisis, pendinginan diharapkan memperlambat metabolisme, mengurangi metabolisme glukosa, meningkatkan kelangsungan hidup PRC. Penyimpanan RBC dengan pendinginan cepat di bawah 150C dapat mencegah hilangnya diphosphoglycerate (DPG) dari RBC. Penelitian ini bertujuan untuk mengetahui pengaruh suhu 20C, 40C, dan 60C terhadap jumlah eritrosit pada darah tranfusi di Bank Darah Rumah Sakit Umum Daerah Dr. Soedarso Pontianak. Desain penelitian berbentuk eksperimen semu. Teknik sampling yang digunakan adalah purposive sampling, dengan jumlah sampel sebanyak 27 sampel, dilakukan dengan 3 perlakuan, 9 kali pengulangan dengan suhu 20C, 40C dan 60C. Perhitungan eritrosit menggunakan metode Automatic Cell Counter. Hasil uji statistic Kendall’s tau didapatkan nilai p (0,673) < α 0,05 berarti Ha ditolak. Sehingga, tidak ada pengaruh suhu penyimpanan suhu 20C, 40C dan 60C terhadap jumlah eritrosit pada darah donor sukarela di Bank Darah Rumah Sakit Umum Daerah Dr. Soedarso Pontianak
Review of recent developments in iodine wasteform production
Authors: Asmussen R. Matthew , Turner Joshua , Chong Saehwa , Riley Brian J.
Published: December 2022

Radioiodine capture and immobilization is not only important to consider during the operation of reactors (i.e., I-131), during nuclear accidents (i.e., I-131 and I-129) or nuclear fuel reprocessing (i.e., I-131 and I-129), but also during disposal of nuclear wastes (i.e., I-129). Most disposal plans for I-129-containing waste forms (including spent nuclear fuel) propose to store them in underground repositories. Here, iodine can be highly mobile and, given its radiotoxicity, needs to be carefully managed to minimize long-term environmental impacts arising from disposal. Typically, any process that has been used to capture iodine from reprocessing or in a reactor is not suitable for direct disposal, rather conversion into a wasteform for disposal is required. The objectives of these materials are to use either chemical immobilization or physical encapsulation to reduce the leaching of iodine by groundwaters. Some of the more recent ideas have been to design capture materials that better align with disposal concepts, making the industrial processing requirements easier. Research on iodine capture materials and wasteforms has been extensive. This review will act as both an update on the state of the research since the last time it was comprehensively summarized, and an evaluation of the industrial techniques required to create the proposed iodine wasteforms in terms of resulting material chemistry and applicability.
Identification of Vibrio ponticus as a bacterial pathogen of coral trout Plectropomus leopardus
Authors: Gai Chunlei , Liu Jie , Zheng Xurui , Xu La , Ye Haibin
Published: December 2022

Vibrio ponticus is a vital pathogen with potential danger for aquaculture animals. Yet V. ponticus pathogenic to the coral trout Plectropomus leopardus is still unknown. In this study, a virulent bacterial strain, temporarily named DX2, was isolated from diseased coral trout suffering liver necrosis with cell vacuolar degeneration, and was identified molecularly and phenotypically as V. ponticus. Besides, the DX2 isolate showed an LD50 value of 6.64×105 CFU mL-1, developed multiple resistances to cephalosporins, macrolides, penicillins, peptides, and sulfonamides antimicrobials, and was highly susceptible to doxycycline and florfenicol in aquaculture use. To the best of our knowledge, this is the first report of the pathogenicity of V. ponticus to the coral trout, and the findings provide a reference for the control of pathogenic V. ponticus in the coral trout.
Case report: Diagnosis of visceral leishmaniasis using metagenomic next-generation sequencing and bone marrow smear
Authors: Zhang Xiaogang , Liu Yanqing , Zhang Mingming , Wang Zhiqiang , Feng Xing , Yang Liu , Wang Yajing , Liu Juan , Zhao Dongbao
Published: December 2022

Visceral leishmaniasis (VL) is a chronic infectious disease transmitted by sandflies. The primary clinical manifestations are remittent fever, pancytopenia, and splenomegaly. As VL is rare with atypical symptoms, its diagnosis is often incorrect, missed, or delayed. Without appropriate treatment, the case fatality rate of symptomatic disease is more than 95%, but the prognosis is good if diagnosed and treated timeously. We report a case of VL that was diagnosed using metagenomic next-generation sequencing (mNGS) of a peripheral blood sample. By using mNGS and a bone marrow smear, we were able to make a timely diagnosis. The patient was treated with antimony, rapidly recovered, and was discharged from the hospital. This case illustrates the value of mNGS for making a timely diagnosis of VL.
C-reactive protein and statins in heart failure with reduced and preserved ejection fraction
Authors: Park Jin Joo , Yoon Minjae , Cho Hyoung-Won , Cho Hyun-Jai , Kim Kye Hun , Yang Dong Heon , Yoo Byung-Su , Kang Seok-Min , Baek Sang Hong , Jeon Eun-Seok , Kim Jae-Joong , Cho Myeong-Chan , Chae Shung Chull , Oh Byung-Hee , Choi Dong-Ju
Published: December 2022

Background

High C-reactive protein (CRP) levels are associated with poor outcomes of heart failure (HF), and statins are known to reduce CRP levels. We investigated the prognostic value of CRP and statin in patients with HF with reduced and preserved ejection fraction (EF).

Methods

Altogether, 3,831 patients from the Korean Acute Heart Failure registry were included and stratified according to the tertiles of CRP levels (T1: CRP < 0.30 mg/dL, T2: 0.30–1.14 mg/dL, and T3: CRP > 1.14 mg/dL). HF with reduced EF (HFrEF), HF with mildly reduced EF (HFmrEF), and HF with preserved EF (HFpEF) were defined as left ventricular ejection fraction (LVEF) ≤ 40%, 41–49%, ≥50%, respectively. The primary endpoints were all-cause, in-hospital, and post-discharge mortality.

Results

No significant correlation was observed between CRP levels and LVEF (r = 0.02, P = 0.131). The prevalence of risk factors increased gradually from T1 to T3 in both the types of HF. Overall, 139 (3.6%) and 1,269 (34.4%) patients died during the index admission and follow-up (median: 995 days), respectively. After adjustment, each increase in the CRP tertiles was independently associated with in-hospital mortality (HFrEF: OR 1.58 and 95% CI 1.09–2.30, HFmrEF: OR 1.51 and 95% CI 0.72–3.52, and HFpEF: OR 2.98, 95% CI 1.46–6.73) and post-discharge mortality (HFrEF: HR 1.20, 95% CI 1.08–1.33, HFmrEF: HR 1.38 and 95% CI 1.12–1.70, and HFpEF: HR 1.37, 95% CI 1.02–1.85). In only patients with LVEF > 40% with highest CRP tertile, statin-users showed better survival trend than those without statins.

Conclusion

CRP is an excellent prognostic marker for HFrEF, HFmrEF, and HFpEF, implying that the neurohumoral and inflammatory pathways might be independent pathways. Statins may be beneficial in HF patients with increased CRP levels.

Clinical trial registration

[https://clinicaltrials.gov/], identifier [NCT013 89843].
Effect of posterior pericardiotomy in cardiac surgery: A systematic review and meta-analysis of randomized controlled trials
Authors: Soletti Giovanni Jr , Perezgrovas-Olaria Roberto , Harik Lamia , Rahouma Mohamed , Dimagli Arnaldo , Alzghari Talal , Demetres Michelle , Bratton Brenden A. , Yaghmour Mohammad , Satija Divyaam , Lau Christopher , Girardi Leonard N. , Salemo Tomas A. , Gaudino Mario
Published: December 2022

Background

Posterior pericardiotomy (PP) has been shown to reduce the incidence of pericardial effusion and postoperative atrial fibrillation (POAF) after cardiac surgery. However, the procedure and the totality of its effects are poorly known in the cardiac surgery community. We performed a study-level meta-analysis of randomized controlled trials (RCTs) to evaluate the impact of PP in cardiac surgery patients.

Methods

A systematic literature search was conducted on three medical databases (Ovid MEDLINE, Ovid Embase, Cochrane Library) to identify RCTs reporting outcomes of patients that received a PP or no intervention after cardiac surgery. The primary outcome was the incidence of POAF. Key secondary outcomes were operative mortality, incidence of pericardial and pleural effusion, cardiac tamponade, length of stay (LOS), pulmonary complications, amount of chest drainage, need for intra-aortic balloon pump, and re-exploration for bleeding.

Results

Eighteen RCTs totaling 3,531 patients were included. PP was associated with a significantly lower incidence of POAF (odds ratio [OR] 0.45, 95% confidence interval [CI] 0.32–0.64, P < 0.0001), early (OR 0.18, 95% CI 0.10–0.34, P < 0.0001) and late pericardial effusion (incidence rate ratio 0.13, 95% CI 0.06–0.29, P < 0.0001), and cardiac tamponade (risk difference −0.02, 95% CI −0.04 to −0.01, P = 0.001). PP was associated with a higher incidence of pleural effusion (OR 1.42, 95% CI 1.06–1.90, P = 0.02), but not pulmonary complications (OR 0.82, 95% CI 0.56–1.19; P = 0.38). No differences in other outcomes, including operative mortality, were found.

Conclusions

PP is a safe and effective intervention that significantly decreases the incidence of POAF and pericardial effusion following cardiac surgery.

Systematic review registration

https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=261485, identifier: CRD42021261485.
Expanding the horizon for breast cancer screening in India through artificial intelligent technologies -A mini-review
Authors: Bhattacharya Sudip , Varshney Saurabh , Heidler Petra , Tripathi Shailesh K.
Published: December 2022

Introduction

Breast cancer is one of the most common cancer among Indian women, with an incidence of 25.8 per 100,000 women according to the Ministry of Health and Family Welfare. Late detection is responsible for poor quality of life (QOL), and it is the leading cause of death. In metropolitan regions, one in every 22 women will have breast cancer over their lifetime; but in rural areas, one in every 60 women will develop breast cancer as per estimates.

Aim and objective

This paper aims to describe the various AI based breast screening technologies which are used in breast cancer screening in India.

Methodology

The literature search was done using “Pub Med,” “Google scholar,” and “Scopus” databases for the key terms “technology,” “cancer research,” “artificial intelligence,” “mammography”, “breast cancer,” “cancer,” and/or “neoplasia in breast.” All the relevant articles were included to support this mini review.

Results

We found that emerging artificial intelligent technologies namely “Niramai”, “iBreastExam,” “MammoAssist” are emerging as an hope for early detection by screening in resource poor settings, in turn, which can improve the QOL among breast cancer patients.
Using health information technology to support the needs of Children with Medical Complexity: Mapping review of consumer informatics applications
Authors: Asan Onur , Elkefi Safa , Clouser Katharine N. , Percy Stephen
Published: December 2022

Background

Children with medical complexity (CMC) are fragile populations that require continuous care and supervision. CMC family caregivers experience many challenges trying to address CMC patients' needs which puts these caregivers in a stressful situation that may negatively impact the care of CMC patients. Consumer informatics might help these caregivers in coordinating care. However, few consumer informatics applications explicitly focus on supporting CMC caregivers' needs.

Objective

This systematic mapping literature review aims to provide an overview and a structured understanding of the consumer informatics designed for CMC and their caregivers.

Methods

We followed a systematic mapping literature review process to provide an overview of the existing Consumer Informatics literature for CMC, which is the scope of our study. We screened IEEE Xplore, Web of Science, and PubMed databases using a preset list of mesh terms that cover the use of medical informatics by children with medical complexities and their caregivers. The selected articles are peer-reviewed English publications that were empirically validated from January 2002 to January 2022. After selecting and filtering the articles, we analyzed them based on the preset mapping questions using the following criteria: publication year, publication source, research type, contribution type, empirical type, the need addressed, target audience, technology users, and consumer informatics' type.

Results

The initial search resulted in a number of (N = 2,275) articles, and 17 selected publications were included. The results showed an increasing interest in CMC consumer informatics publications over time. Most of the studies were published in 2021, and feasibility research is the dominant research type. The most used technology was telehealth and telemedicine, followed by mobile health. The technologies addressed various needs, including; coordination & follow-up, medical safety, education & social support, daily living activities, shared decision making, information seeking, and emotional support. Most of the efforts were focused on ensuring good coordination and follow-up.

Conclusions

CMC consumer informatics is a promising research field to present novel initiatives and approaches to manage the caregivers' workload. Future research should be shifted toward providing more evidence-based studies to examine the effectiveness of CMC consumer informatics solutions and identify the related challenges and limitations.
Deprescribing as a strategy for improving safety of medicines in older people: Clinical and regulatory perspective
Authors: Crisafulli Salvatore , Poluzzi Elisabetta , Lunghi Carlotta , Di Francesco Vincenzo , Pellizzari Luca , Pasina Luca , Elli Chiara , Trotta Francesco , Cangini Agnese , Trevisan Caterina , Zazzara Maria Beatrice , Onder Graziano , Trifirò Gianluca
Published: December 2022

The ageing process is associated with an increased probability of accumulating health deficits, chronic conditions and geriatric syndromes, leading to a growing prevalence of multimorbidity, defined as the co-occurrence of two or more chronic conditions (of which, at least one physical condition). One of the most frequent and direct consequences of multimorbidity, especially amongst older adults, is polypharmacy, a condition characterized by the concomitant use of five or more drugs per day. Polypharmacy is one of the main risk factors for adverse clinical outcomes, including drug-drug interactions and adverse drug reactions, also resulting in increased hospitalizations, morbidity, and increased use of healthcare resources, with considerable implications for healthcare costs. Deprescribing is one of potential approaches to reduce inappropriate prescribing and it is defined as the stopping or dose reduction of medications that are either inappropriate or unnecessary, especially among patients with polypharmacy. In this review, the major issues associated with polypharmacy among older people, the current guidelines for the management of polypharmacy and the strategies to implement deprescribing in different settings (i.e., hospital setting, nursing homes and general practice) are discussed.
Misperception of body weight and associated socioeconomic and health-related factors among Korean female adults: A nationwide population-based study
Authors: Joo Yoonjung Yoonie , Kim Jina , Lee Kiwon , Cho Geum Joon , Yi Kyong Wook
Published: December 2022

Background

Misperception of body weight is associated with various psychological and health problems, including obesity, eating disorders, and mental problems. To date, female-specific risk factors, including socioeconomic or health-related lifestyle features, or their indicative performance for the misperception in Asian women according to age groups remain unknown.

Objectives

To investigate the prevalence and associated risk factors for the mismatch in self-perceived body weight and evaluated the classification performance of the identified risk factors across age groups in female adults.

Methods

We analyzed data of 22,121 women (age 19–97 years) from the 7-year Korea National Health and Nutrition Examination Survey dataset (2010-2016). We evaluated self-perceived body weight of the participants with their actual weight using the body mass index cut-off and grouped them by age: early adulthood (19–45), middle adulthood (46–59), and late adulthood (≥60). Logistic regression was conducted in each age group based on their weight misperception. The classification performance of the identified risk factors was evaluated with a bagging tree ensemble model with 5-fold cross-validation.

Results

22.2% (n=4,916) of the study participants incorrectly perceived their body weight, of which 14.1% (n=3,110) and 8.2% (n=1,806) were in the underestimated and overestimated groups. Among the age groups, the proportion of participants who misperceived their body weight was highest in late adulthood (31.8%) and the rate of overestimation was highest in early adulthood (14.1%). We found that a lower education level, absence of menopause, perception of themselves as unhealthy, and efforts for weight management were significantly associated with the overall misperception (overestimation or underestimation) of body weight across age groups. Based on the identified risk factors, the highest area under the receiver operating curve (AUROC) and accuracy of the best classification model (weight overestimation in all participants) were 0.758 and 0.761, respectively. Adding various associated lifestyle factors to the baseline model resulted in an average increase of 0.159 and 0.135 in AUROC for classifying weight underestimation and overestimation, respectively.

Conclusions

Age, education level, marital status, absence of menopause, amount of exercise, efforts for weight management (gain, loss, and maintenance), and self-perceived health status were significantly associated with the mismatch of body weight.
Impact of glucose metabolism on the developing brain
Authors: Cacciatore Marta , Grasso Eleonora Agata , Tripodi Roberta , Chiarelli Francesco
Published: December 2022

Glucose is the most important substrate for proper brain functioning and development, with an increased glucose consumption in relation to the need of creating new brain structures and connections. Therefore, alterations in glucose homeostasis will inevitably be associated with changes in the development of the Nervous System. Several studies demonstrated how the alteration of glucose homeostasis - both hyper and hypoglycemia- may interfere with the development of brain structures and cognitivity, including deficits in intelligence quotient, anomalies in learning and memory, as well as differences in the executive functions. Importantly, differences in brain structure and functionality were found after a single episode of diabetic ketoacidosis suggesting the importance of glycemic control and stressing the need of screening programs for type 1 diabetes to protect children from this dramatic condition. The exciting progresses of the neuroimaging techniques such as diffusion tensor imaging, has helped to improve the understanding of the effects, outcomes and mechanisms underlying brain changes following dysglycemia, and will lead to more insights on the physio-pathological mechanisms and related neurological consequences about hyper and hypoglycemia.
Physiological and pathological roles of Ang II and Ang- (1-7) in the female reproductive system
Authors: Liu Yuanyuan , Hao Haomeng , Lan Tingting , Jia Rui , Cao Mingya , Zhou Liang , Zhao Zhiming , Pan Wensen
Published: December 2022

The local Renin-Angiotensin System (RAS) has been demonstrated to exist in a wide range of tissues and organs, In the female reproductive system, it is mainly found in the ovary, uterus and placenta. The RAS system is made up of a series of active substances and enzymes, in addition to the circulating endocrine renin-angiotensin system. The active peptides Angiotensin II (Ang II) and Angiotensin (1-7) (Ang-(1-7)), in particular, appear to have distinct activities in the local RAS system, which also controls blood pressure and electrolytes. Therefore, in addition to these features, angiotensin and its receptors in the reproductive system seemingly get involved in reproductive processes, such as follicle growth and development, as well as physiological functions of the placenta and uterus. In addition, changes in local RAS components may induce reproductive diseases as well as pathological states such as cancer. In most tissues, Ang II and Ang- (1-7) seem to maintain antagonistic effects, but this conclusion is not always true in the reproductive system, where they play similar functions in some physiological and pathological roles. This review investigated how Ang II, Ang- (1-7) and their receptors were expressed, localized, and active in the female reproductive system. This review also summarized their effects on follicle development, uterine and placental physiological functions. The changes of local RAS components in a series of reproductive system diseases including infertility related diseases and cancer and their influence on the occurrence and development of diseases were elucidated. This article reviews the physiological and pathological roles of Ang II and Ang- (1-7) in female reproductive system,a very intricate system of tissue factors that operate as agonists and antagonists was found. Besides, the development of novel therapeutic strategies targeting components of this system may be a research direction in future.
Preoperative prediction of residual back pain after vertebral augmentation for osteoporotic vertebral compression fractures: Initial application of a radiomics score based nomogram
Authors: Ge Chen , Chen Zhe , Lin Yazhou , Zheng Yuehuan , Cao Peng , Chen Xiaoyong
Published: December 2022

Background

Most patients with osteoporotic vertebral compression fracture (OVCF) obtain pain relief after vertebral augmentation, but some will experience residual back pain (RBP) after surgery. Although several risk factors of RBP have been reported, it is still difficult to estimate the risk of RBP preoperatively. Radiomics is helpful for disease diagnosis and outcome prediction by establishing complementary relationships between human-recognizable and computer-extracted features. However, musculoskeletal radiomics investigations are less frequently reported.

Objective

This study aims to establish a radiomics score (rad-score) based nomogram for the preoperative prediction of RBP in OVCF patients.

Methods

The training cohort of 731 OVCF patients was used for nomogram development, and the validation cohort was utilized for performance test. RBP was determined as the score of visual analogue scale ≥ 4 at both 3 and 30 days following surgery. After normalization, the RBP-related radiomics features were selected to create rad-scores. These rad-scores, along with the RBP predictors initially identified by univariate analyses, were included in the multivariate analysis to establish a nomogram for the assessment of the RBP risk in OVCF patients preoperatively.

Results

A total of 81 patients (11.2%) developed RBP postoperatively. We finally selected 8 radiomics features from 1316 features extracted from each segmented image to determine the rad-score. Multivariate analysis revealed that the rad-score plus bone mineral density, intravertebral cleft, and thoracolumbar fascia injury were independent factors of RBP. Our nomograms based on these factors demonstrated good discrimination, calibration, and clinical utility in both training and validation cohorts. Furthermore, it achieved better performance than the rad-score itself, as well as the nomogram only incorporating regular features.

Conclusion

We developed and validated a nomogram incorporating the rad-score and regular features for preoperative prediction of the RBP risk in OVCF patients, which contributed to improved surgical outcomes and patient satisfaction.