bluuebunny/crossref_metadata_2025 huggingface dataset:
A method of chained recommendation for charging piles in internet of vehicles
Authors: Zhang Tianle , Zheng Liwen , Jiang Yu , Tian Zhihong , Du Xiaojiang , Guizani Mohsen
Published: July 2020

With the popularization of new energy electric vehicles (EVs), the recommendation algorithm is widely used in the relatively new field of charge piles. At the same time, the construction of charging infrastructure is facing increasing demand and more severe challenges. With the ubiquity of Internet of vehicles (IoVs), inter-vehicle communication can share information about the charging experience and traffic condition to help achieving better charging recommendation and higher energy efficiency. The recommendation of charging piles is of great value. However, the existing methods related to such recommendation consider inadequate reference factors and most of them are generalized for all users, rather than personalized for specific populations. In this paper, we propose a recommendation method based on dynamic charging area mechanism, which recommends the appropriate initial charging area according to the user's warning level, and dynamically changes the charging area according to the real-time state of EVs and charging piles. The recommendation method based on a classification chain provides more personalized services for users according to different charging needs and improves the utilization ratio of charging piles. This satisfies users' multilevel charging demands and realizes a more effective charging planning, which is beneficial to overall balance. The chained recommendation method mainly consists of three modules: intention detection, warning levels classification, and chained recommendation. The dynamic charging area mechanism reduces the occurrence of recommendation conflict and provides more personalized service for users according to different charging needs. Simulations and computations validate the correctness and effectiveness of the proposed method.
Worsening Child Outcomes? Caregiver Imprisonment and Its Impact on Child Poverty, Health, Well-being and Education in Uganda
Authors: Butler Michelle , Misinde Cyprian
Published: July 2020

Increasingly, research investigates how the imprisonment of those with child care responsibilities may affect children and their outcomes. However, this research is often conducted in high-income, developed countries, with little known about its impact in low-income, least developed countries. This study starts to address this gap by examining if the imprisonment of those with child care responsibilities in Uganda, a low-income least developed country, may affect child poverty, wellbeing, health, diet, and education. Drawing on 76 interviews conducted with 61 adults and 15 children, participants were asked to recount what affect, if any, imprisonment of the child’s caregiver was believed to have on child poverty, health, wellbeing, diet, and education. The findings reveal that imprisonment was believed to have a largely negative effect on these aspects of children’s lives for most children, hindering government efforts to improve child outcomes and tackle key development challenges. Based on these findings, it is argued that our theoretical understanding of imprisonment and its effects may need to be broadened to include how differing socio-economic policy contexts may moderate the impact of imprisonment on child outcomes.
Identification of Genes Involved in Root Growth Inhibition Under Lead Stress by Transcriptome Profiling in Arabidopsis
Authors: Zheng Shuangshuang , Ren Panrong , Zhai Mingtong , Li Chuanyou , Chen Qian
Published: July 2020

Lead (Pb) is a heavy metal with high toxicity to plants. Root is the major organ to respond to Pb stress. However, little is known about how plant roots perceive Pb stress signaling. Here, we describe the transcriptome of Arabidopsis root tips under Pb stress using the RNA-seq assay. A total of 703 differentially expressed genes (DEGs) were identified and expressed at every time points. Some early-responsive DEGs (1 h) were predicted to be negatively involved in cell elongation and cell expansion, while some late-responsive DEGs (24 h) positively participated in defense of oxidative stress. Hydrogen peroxide (H2O2) and superoxide (O2−) were increased significantly in root tips under Pb stress. Cell wall extension related gene XYLOGLUCAN ENDOTRANSGLUCOSYLASE/HYDROLASE 18 (XTH18) was induced in root tips, and xth18 showed reduced root growth inhibition by Pb stress. Our results revealed the potential mechanism of root growth inhibition by Pb stress and shed light for the further study.
Niṣkāmakarma and the Prisoner’s Dilemma
Authors: Lehtonen Tommi
Published: July 2020

TheBhagavadgītā, part of the sixth book of the Hindu epic TheMahābhārata, offers a practical approach tomokṣa, or liberation, and freedom fromsaṃsāra, or the cycle of death and rebirth. According to the approach, known askarmayoga(‘the yoga of action’), salvation results from attention to duty and the recognition of past acts that inform the present and will direct the future. In theBhagavadgītā, Kṛṣṇa advocates selfless action as the ideal path to realizing the truth about oneself as well as the ultimate reality. Kṛṣṇa proclaims that humans have rights only to actions and not to their results, whether good or bad (2.47). Therefore, humans should not desire any results whatsoever. The prisoner’s dilemma is a fictional story that shows why individuals who seek only their personal benefit meet worse outcomes than those possible by cooperating with others. The dilemma provides an effective, albeit often overlooked, method for studying the Hindu principle ofniṣkāmakarma(‘desireless action’) that is arguably the central teaching of theBhagavadgītā. In the context of the prisoner’s dilemma, a prisoner who wants to upholdniṣkāmakarmamay choose one of two decision-making strategies: to be indifferent and leave the decision to chance or to either pursue the common good or the other person’s benefit instead of his or her own. Assuming that followers ofniṣkāmakarmacan be goal-oriented, the second strategy is more appropriate than the first, as long as one pursues unselfish goals and remains both indifferent and uncommitted to personal benefit.
Management of the Patient with Heart Failure and an Implantable Pulmonary Artery Hemodynamic Sensor
Authors: Abraham Jacob , McCann Patrick J. , Guglin Maya E. , Bhimaraj Arvind , Benjamin Terrie-Ann S. , Robinson Monique R. , Jonsson Orvar T. , Feitell Scott C. , Bhatt Kunjan A. , Bennett Mosi K. , Heywood J.T. ,   on behalf of Hemodynamic Frontiers in Heart Failure (HF2) Investigators
Published: July 2020

Purpose of Review

Heart failure (HF) management guided by hemodynamics obtained from an implantable pulmonary artery pressure (PAP) sensor (CardioMEMS) improves symptoms and reduces HF hospitalizations (HFH). This paper reviews the theoretical basis of pulmonary vascular physiology, summarizes recently published data about CardioMEMS, and provides practical guidelines for patient selection and management.

Recent Findings

Compared to patients managed by standard care, HF patients randomized to PAP-guided treatment have a higher frequency of medication adjustments, resulting in lower PAP and fewer HFH. Real-world analyses further support associations between implant of the CardioMEMS sensor with reductions in PAP, hospitalizations, and mortality.

Implantable, wireless hemodynamic sensor technology is a promising remote monitoring platform for chronic HF. A phased approach using a treatment algorithm may improve the efficiency and effectiveness of pressure-guided therapy.
Effects of Cerebellar tDCS on Inhibitory Control: Evidence from a Go/NoGo Task
Authors: Mannarelli Daniela , Pauletti Caterina , Petritis Alessia , Delle Chiaie Roberto , Currà Antonio , Trompetto Carlo , Fattapposta Francesco
Published: July 2020

Response inhibition as an executive function refers to the ability to suppress inappropriate but prepotent responses. Several brain regions have been implicated in the process underlying inhibitory control, including the cerebellum. The aim of the present study was to explore the role of the cerebellum in executive functioning, particularly in response inhibition. For this purpose, we transitorily inhibited cerebellar activity by means of cathodal tDCS and studied the effects of this inhibition on ERP components elicited during a Go/NoGo task in healthy subjects. Sixteen healthy subjects underwent a Go/NoGo task prior to and after cathodal and sham cerebellar tDCS in separate sessions. A reduction in N2-NoGo amplitude and a prolongation in N2-NoGo latency emerged after cathodal tDCS whereas no differences were detected after sham stimulation. Moreover, commission errors in NoGo trials were significantly higher after cathodal tDCS than at the basal evaluation. No differences emerged between performances in Go trials and those after sham stimulation. These data indicate that cerebellar inhibition following cathodal stimulation alters the ability to allocate attentional resources to stimuli containing conflict information and the inhibitory control. The cerebellum may regulate the attentional mechanisms of stimulus orientation and inhibitory control both directly, by making predictions of errors or behaviors related to errors, and indirectly, by controlling the functioning of the cerebral cortical areas involved in the perception of conflict signals and of the basal ganglia involved in the inhibitory control of movement.
Can we Use Conceptual Spaces to Model Moral Principles?
Authors: Verheyen Steven , Peterson Martin
Published: July 2020

Can the theory of conceptual spaces developed by Peter Gärdenfors (2000, 2014) and others be applied to moral issues? Martin Peterson (2017) argues that several moral principles can be construed as regions in a shared similarity space, but Kristin Shrader-Frechette (2017) and Gert-Jan Lokhorst (2018) question Peterson’s claim. They argue that the moral similarity judgments used to construct the space are underspecified and subjective. In this paper, we present new data indicating that moral principles can indeed be construed as regions in a multidimensional conceptual space on the basis of moral similarity judgments. Four hundred and seventy-five students taking a course in engineering ethics completed a survey in which they were presented with ten cases (moral choice situations) featuring ethical issues related to technology and engineering. Participants were asked to judge the moral similarity of each pair of cases (45 comparisons) and to select which moral principle (from a list of five alternatives plus a sixth option: “none of the principle listed here”) they believed should be applied for resolving the case. We used interval multidimensional scaling (MDS) as well as individual differences scaling (INDSCAL) for analyzing the moral similarity judgments. Despite noteworthy individual variations in the judgments, the five moral principles included in the study were discernable in the aggregate multidimensional spaces, even for participants with no previous exposure to the principles. Participants tended to apply the same moral principles to cases rated as morally similar. Our overall conclusion is that moral similarity judgments, and their representation in multidimensional spaces, can help us identify moral principles that are relevant for assessing difficult moral choice situations.
Synchronic and diachronic identity for elementary particles
Authors: Bigaj Tomasz
Published: July 2020

The main focus of this paper is on the notion of transtemporal (diachronic) identity applied to quantum particles. I pose the question of how the symmetrization postulate with respect to instantaneous states of particles of the same type affects the possibility of identifying interacting particles before and after their interaction. The answer to this question turns out to be contingent upon the choice between two available conceptions of synchronic individuation of quantum particles that I call the orthodox and heterodox approaches. I argue that the heterodox approach offers a better explanation of the known experimental facts regarding particle interactions, and I probe deeper the concepts of synchronic and diachronic identity emerging from this approach.
Habitat selection of white-tailed deer fawns and their dams in the Northern Great Plains
Authors: Michel Eric S. , Gullikson Bailey S. , Brackel Katherine L. , Schaffer Brian A. , Jenks Jonathan A. , Jensen William F.
Published: July 2020

Habitat availability can affect important life-history traits such as survival; however, little information exists on how microhabitat characteristics found at parturition sites selected by dams and bed sites selected by their offspring differ from the surrounding area and from each other. Therefore, we assessed how vegetation affected maternal parturition and offspring bed site selection for white-tailed deer (Odocoileus virginianus) in the Northern Great Plains. Dams selected for sites with decreased vegetation height, potentially improving their visibility, which may increase their ability to escape approaching predators. Conversely, there was no variation between vegetative characteristics at neonate bed sites and their associated random sites, indicating grasslands provide adequate concealment for neonates. Dams possess the ability to flee from approaching predators, thus increasing the importance of visibility while giving birth. Conversely, neonates depend on fear bradycardia as their main antipredator defense, so concealment is more important. Our results suggest that vegetation structure is an important characteristic to white-tailed deer as habitat needs vary between adults and neonates.
Detection of distal ureteral stones in pregnancy using transvaginal ultrasound
Authors: Bold Michael S. , Boyum James H. , Potretzke Aaron M. , Rose Carl H. , Atwell Thomas D. , Sviggum Erik B. , Goss Brian C. , Brown Douglas L.
Published: July 2020

Aims

To determine the performance of transvaginal ultrasound for the visualization of distal ureteral stones in pregnant patients with renal colic and to evaluate the diagnostic value of secondary findings suggestive of obstructing ureteral stone disease.

Methods

We retrospectively identified 129 pregnant patients with a total of 142 encounters with both abdominal and transvaginal ultrasound. Ultrasound images for each patient were reviewed recording the presence of stone with location, hydronephrosis, resistive indices (RI), and status of the ureteral jets. Patients were subcategorized into two groups based on the visualization of distal ureteral stone.

Results

The transvaginal technique identified 94% (N = 16/17) of sonographically detected stones in the distal ureter/urethra, while the transabdominal technique identified 29% (N = 5/17). The combined imaging for initial assessment of renal colic in pregnancy demonstrated a sensitivity of 89%, specificity 100%, and negative predictive value (NPV) of 98%. The frequency of hydronephrosis was statistically greater in the visualized stone group (94% vs 51%). Mean RI was identical in both groups however the delta RI was significantly elevated in those patients with distal ureteral stones with a mean delta RI value of 0.05. The rate of absence of ureteral jets was not statistically significant.

Conclusion

The present data would suggest a utility of transvaginal ultrasound for the evaluation of the pregnant patient with 94% of distal stones being detected transvaginal versus 29% transabdominally. Additionally, there was significantly increased hydronephrosis and elevated RIs in patients with distal ureteral stones.
Ciproterone acetato e meningiomi: lo stato dell’arte
Authors: Senofonte Giulia , Pallotti Francesco , Lombardo Francesco
Published: July 2020

Sommario

L’impiego di ciproterone acetato è stato associato all’insorgenza di meningiomi nella popolazione generale e in quella transgender. Il maggiore rischio sembra correlato alla dose impiegata e al tempo in cui si segue la terapia e più alta è l’incidenza di meningiomi nella popolazione transgender femminile che non nella popolazione generale. Massima attenzione deve essere posta dal clinico a eventuali sintomi presenti e, per minimizzare tale rischio, scegliere il minor dosaggio efficace possibile.
Herzfrequenzvariabilitätsanalyse in der betriebsärztlichen Praxis
Authors: Böckelmann I. , Sammito S.
Published: July 2020

In dem vorliegenden Beitrag werden basierend auf einer selektiven Literaturrecherche und unter Berücksichtigung aktueller Leitlinien die Rahmenbedingungen der Herzfrequenzvariabilitätsanalyse (HRV-Analyse), die Auswahl der HRV-Parameter bei den verschiedenen Fragestellungen und die Möglichkeiten der Nutzbarkeit der HRV für die betriebsärztliche Praxis zusammengefasst. Inzwischen in der praktischen Anwendung gut etabliert, werden die HRV-Parameter als Beanspruchungsindikatoren für die Einschätzung der Regulationsmechanismen und funktionalen Reserven des Herz-Kreislauf-Systems eingesetzt.
DeepECT: The Deep Embedded Cluster Tree
Authors: Mautz Dominik , Plant Claudia , Böhm Christian
Published: July 2020

The idea of combining the high representational power of deep learning techniques with clustering methods has gained much attention in recent years. Optimizing a clustering objective and the dataset representation simultaneously has been shown to be advantageous over separately optimizing them. So far, however, all proposed methods have been using a flat clustering strategy, with the actual number of clusters known a priori. In this paper, we propose the Deep Embedded Cluster Tree (DeepECT), the first divisive hierarchical embedded clustering method. The cluster tree does not need to know the actual number of clusters during optimization. Instead, the level of detail to be analyzed can be chosen afterward and for each sub-tree separately. An optional data-augmentation-based extension allows DeepECT to ignore prior-known invariances of the dataset, such as affine transformations in image data. We evaluate and show the advantages of DeepECT in extensive experiments.
Bayesian covariance structure modelling for measurement invariance testing
Authors: Fox Jean-Paul , Koops Jesse , Feskens Remco , Beinhauer Lukas
Published: July 2020

In a Bayesian Covariance Structure Model (BCSM) the dependence structure implied by random item parameters is modelled directly through the covariance structure. The corresponding measurement invariance assumption for an item is represented by an additional correlation in the item responses in a group. The BCSM for measurement invariance testing is defined for mixed response types, where the additional correlation is tested with the Bayes factor. It is shown that measurement invariance can be tested simultaneously across items and thresholds for multiple groups. This avoids the risk of capitalization on chance that occurs in multiple-step procedures and avoids cumbersome procedures where items are examined sequentially. The proposed measurement invariance procedure is applied to PISA data, where the advantages of the method are illustrated.
Functional and cognitive outcomes after COVID-19 delirium
Authors: Mcloughlin Benjamin C. , Miles Amy , Webb Thomas E. , Knopp Paul , Eyres Clodagh , Fabbri Ambra , Humphries Fiona , Davis Daniel
Published: July 2020

Purpose

To ascertain delirium prevalence and outcomes in COVID-19.

Methods

We conducted a point-prevalence study in a cohort of COVID-19 inpatients at University College Hospital. Delirium was defined by DSM-IV criteria. The primary outcome was all-cause mortality at 4 weeks; secondary outcomes were physical and cognitive function.

Results

In 71 patients (mean age 61, 75% men), 31 (42%) had delirium, of which only 12 (39%) had been recognised by the clinical team. At 4 weeks, 20 (28%) had died, 26 (36%) were interviewed by telephone and 21 (30%) remained as inpatients. Physical function was substantially worse in people after delirium − 50 out of 166 points (95% CI − 83 to − 17,p = 0.01). Mean cognitive scores at follow-up were similar and delirium was not associated with mortality in this sample.

Conclusions

Our findings indicate that delirium is common, yet under-recognised. Delirium is associated with functional impairments in the medium term.
Advances in targeting EGFR allosteric site as anti-NSCLC therapy to overcome the drug resistance
Authors: Maity Swastika , Pai K. Sreedhara Ranganath , Nayak Yogendra
Published: July 2020

Background

The epidermal growth factor receptor (EGFR) inhibitors represent the first-line therapy regimen for non-small cell lung cancer (NSCLC). Most of these inhibitors target the ATP-site to stop the aggressive development of NSCLC. Stabilization of the ATP-binding on EGFR is difficult due to autophosphorylation of the EGFR domain. This leads to activation of nonintrinsic influence of the tumor microenvironment and expression of anti-apoptotic pathways and drug resistance.

Methods

The NSCLC related literature search was carried out using online databases such as Scopus, Web of Sciences, PubMed, Protein Data Bank and UniPort for the last ten years and selected articles are referred for discussion in this review.

Results

To overcome the problem of mutations in NSCLC, the allosteric site of EGFR was targeted, which shows significant therapeutic outcome without causing resistance. Compounds like EAI001, EAI045 JBJ-04-125-02, DDC4002 and a series of small molecules with an affinity towards the EGFR allosteric site are reported and are under the investigational stage. These compounds are categorized under fourth-generation anti-NSCLC agents.

Conclusion

Composition of this review highlights the advantage of inhibiting allosteric site in the EGFRTK receptor domains and presents a comparative analysis of the new fourth-generation anti-NSCLC agents to overcome the drug resistance.
Solidification effects of snowfall on sea-ice freeze-up: results from an onsite experimental study
Authors: Toyota Takenobu , Ono Takashi , Tanikawa Tomonori , Wongpan Pat , Nomura Daiki
Published: July 2020

Although the effects of snow during sea-ice growth have been investigated for sea ice which is thick enough to accommodate dry snow, those for thin sea ice have not been paid much attention due to the difficulty in observing them. Observations are complicated by the presence of slush and its subsequent freeze-up, and the surface heat budget might be sensitive to the additional ice thickness. An onsite short-term land fast sea-ice freeze-up experiment in the Saroma-ko Lagoon, Hokkaido, Japan was carried out to examine the effects of snowfall on the structure and surface heat budget of thin sea ice, based on observational results and a 1-D thermodynamic model. We found that snowfall contributes to the solidification of the surface slush layer, contributing ice thickness that is comparable to the snowfall amount and affecting the crystal texture significantly. On the other hand, the basal ice growth rate and turbulent heat flux were not significantly affected, being <3.1 × 10−8m s−1and 3 W m−2, respectively. This finding may validate the omission in past studies of snow effect in estimating ice production rates in polynyas and has implications about the reconstruction of growth history from sample analysis.
Response of the Public to Preventive Measures of COVID-19 in Iraqi Kurdistan
Authors: Abdulah Deldar Morad , Aziz Qazli Salem Said , Suleman Sherzad Khudeida
Published: July 2020

Objectives:

On March 1, 2020, the Kurdistan Region Government (KRG) announced 4 confirmed cases of coronavirus disease (COVID-19). We aimed to explore the response of the public toward the prevention principles against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Methods:

The investigators invited individuals from different geographic areas of Duhok Governorate of Iraqi Kurdistan in March 2020.

Results:

The mean age of the participants was 25.74 (16‐95 years). The mean score and prevalence of fear toward SARS-CoV-2 infection was 4.40 of 10 and 81.9%, respectively. A small percentage of participants did not minimize their exposures by reducing close contacts and transmission of respiratory droplets (14.5%) and visited public areas during the epidemic (28.7%). The study revealed that 30.8% of the participants do not use face masks or tissues when they sneeze in public areas. Most of the participants wash their hands when they suspect a possible transmission of the SARS-CoV-2 pathogen (94.6%) and clean or disinfect pathogen contamination-suspected areas at home (84.6%). The study also revealed that some participants (11.2%), due to a lower education, did not visit a medical clinic when they experienced possible symptoms of SARS-CoV-2 infection. Participants agreed with the health policies of KRG against the COVID-19 outbreak (90.8%).

Conclusions:

Some individuals do not adhere to preventive measures against SARS-CoV-2 infection.
Changes in Body Weight, Physical Activity, and Lifestyle During the Semi-lockdown Period After the Outbreak of COVID-19 in China: An Online Survey
Authors: He Ming , Xian Yin , Lv Xiaodong , He Jinsong , Ren Yixing
Published: July 2020

Objectives:

The outbreak of novel coronavirus (COVID-19) provided an opportunity to undertake an online survey to study the relationships between body weight changes with changes in physical activity and lifestyle during an unusual event of forced isolation, or quarantine.

Methods:

We distributed an electronic questionnaire using the popular social application WeChat to adults from any province of China except Hubei Province, the epicenter of the outbreak. The questionnaire asked for demographic information, body weight, physical activity, and lifestyle factors before and during the quarantine.

Results:

Of 376 questionnaires returned, 339 were valid (90.2%). During the period of semi-lockdown, both females and males with BMI <24 gained weight, males with BMI ≥24 lost weight, and females with BMI ≥24 gained weight. The average steps per day and the average moderate or vigorous-intensity exercise declined significantly for both males and females during the semi-lockdown. Changes in body weight inversely correlated with changes in steps per day and moderate or vigorous-intensity exercise during the quarantine.

Conclusions:

Normal weight individuals, who are not normally troubled by overweight or obesity, had less awareness of weight gain than people with a BMI ≥ 24. Under the conditions of the semi-lockdown, they tended to gain weight.
Emergency Care Systems: The Missing Link for Effective Treatment of COVID-19 in Africa
Authors: Calvello Hynes Emilie J. , Bills Corey B.
Published: July 2020

Cases of COVID-19 are rising quickly on the African continent. A critical element of any health system response to such a surge of active cases is the existence of functional emergency care systems. Yet, these systems are markedly underdeveloped in African countries. This short letter reviews the key role emergency medicine plays in epidemic disease response and actions that ministries of health can take now to shore up gaps in emergency care capacity to avoid needless death and suffering of COVID-19 patients.
Why We Need More Histories of Low-Status Institutions
Authors: Bañuelos Nidia
Published: July 2020

As scholars of higher education regularly point out, American universities face a fundamental tension between access and exclusion. On the one hand, as publicly supported institutions operating in a democracy, they are charged with promoting social mobility and sharing knowledge that can improve society. On the other, they are tasked with identifying and supporting elites—those talented, ambitious, and hardworking individuals who deserve the most money and accolades. In his 1993 History of Education Society presidential address, “Race, Meritocracy, and the American Academy during the Immediate Post-World War II Era,” historian James Anderson describes one way in which northern white colleges and universities coped with this tension after World War II. During this time, Fred Wale, director of education for the Julius Rosenwald Fund, compiled a list of 150 outstanding black scholars with degrees from schools like the University of Chicago, Harvard, Columbia, and the University of Michigan; extensive teaching experience at historically black colleges and universities (HBCUs); and highly regarded publication records. Wale sent his list to hundreds of university presidents, encouraging them to consider these qualified candidates for faculty appointments. His efforts made minimal impact: between 1945 and 1947, only twenty-three of the scholars on Wale's list were offered permanent faculty positions at northern white universities.
Moche Mortuary Pottery and Culture Change
Authors: Quilter Jeffrey
Published: July 2020

In this article, I investigate the Northern and Southern Moche archaeological cultures by evaluating the data gathered and theories developed since their first identification 25 years ago. I suggest that what was previously considered the Southern Moche tradition was the dominant one throughout most of the North Coast, with regional variations, prior to about AD 650. After that date, the “Classic Moche” tradition ended in both regions and was succeeded by distinct Northern and Southern ceramic and mortuary traditions and, inferentially, reorganized social, political, and religious systems as well. The relations between regional mortuary and other traditions and fineware styles are considered in light of pan-regional dynamics including the ascendancy of the Wari Empire.
Estimating dispersal and evolutionary dynamics in diploporan blastozoans (Echinodermata) across the great Ordovician biodiversification event
Authors: Lam Adriane R. , Sheffield Sarah L. , Matzke Nicholas J.
Published: July 2020

Echinoderms make up a substantial component of Ordovician marine invertebrates, yet their speciation and dispersal history as inferred within a rigorous phylogenetic and statistical framework is lacking. We use biogeographic stochastic mapping (BSM; implemented in the R package BioGeoBEARS) to infer ancestral area relationships and the number and type of dispersal events through the Ordovician for diploporan blastozoans and related species. The BSM analysis was divided into three time slices to analyze how dispersal paths changed before and during the great Ordovician biodiversification event (GOBE) and within the Late Ordovician mass extinction intervals. The best-fit biogeographic model incorporated jump dispersal, indicating this was an important speciation strategy. Reconstructed areas within the phylogeny indicate the first diploporan blastozoans likely originated within Baltica or Gondwana. Dispersal, jump dispersal, and sympatry dominated the BSM inference through the Ordovician, while dispersal paths varied in time. Long-distance dispersal events in the Early Ordovician indicate distance was not a significant predictor of dispersal, whereas increased dispersal events between Baltica and Laurentia are apparent during the GOBE, indicating these areas were important to blastozoan speciation. During the Late Ordovician, there is an increase in dispersal events among all paleocontinents. The drivers of dispersal are attributed to oceanic and epicontinental currents. Speciation events plotted against geochemical data indicate that blastozoans may not have responded to climate cooling events and other geochemical perturbations, but additional data will continue to shed light on the drivers of early Paleozoic blastozoan speciation and dispersal patterns.
BRITAIN'S ROYAL BALLET IN APARTHEID SOUTH AFRICA, 1960
Authors: QUINTON LAURA
Published: July 2020

This article reconstructs and analyses, for the first time, the Royal Ballet's state-sponsored tour of apartheid South Africa from February to April 1960. It traces the public outcry surrounding the company's decision to exclude its only dancer of colour, as well as the tour's planning, execution, and continuation through the Sharpeville massacre, local reception, and aftermath. In this episode of the post-war period, politics and high culture operated in tandem to sustain Britain's imperial connections amid decolonization and the Cold War. The article proposes a reframing of the ‘Wind of Change’ moment, analyses the role of ballet in Britain's cultural Cold War, and underscores the British state's willingness to set aside human and moral concerns for political advantage. Above all, it argues that, rather than being peripheral to, or merely reflecting, the British state's agenda, ballet enacted its politics.
THE COSMOPOLITAN HISTORIOGRAPHY OF TWENTIETH-CENTURY FEDERALISM
Authors: FEJZULA MERVE
Published: July 2020

This article examines the historiographical debate over federalism between the 1930s and 1960s. In their most sweeping iterations, revisionists have sought to unravel the history of the nation-state, by using the history of anti-colonial federalist demands for equal incorporation into imperial states as evidence against a teleology of nationalist independence. In perceiving the democratic potentialities embedded within imperial state forms, revisionists argue that anti-colonial federalists therefore belong within a cosmopolitan tradition of seeking democratic supra-national governance beyond empire and nation. Some iterations of ‘post-colonial cosmopolitanism’ have unfortunately channelled debate into an opposition between federalism and nationalism, while also generating methodological republicanism, the tendency to view proto-republics within imperial formations. This review challenges these interpretive shortcomings and argues instead that federalism ought to be understood as part of a contest about the state as such. By integrating scholarship on French and British imperial federalism with recent work on regional federalisms in European and African contexts, this essay centres a whole range of ideological variations of ‘cosmopolitanism’ that adapted federalism to their critiques of the state. Ultimately, this reframing of federalist historiography enables new insights into contests about, and not just over, twentieth-century states.
Timing and order of exposure to two echinostome species affect patterns of infection in larval amphibians
Authors: Billet Logan S. , Wuerthner Vanessa P. , Hua Jessica , Relyea Rick A. , Hoverman Jason T.
Published: July 2020

The study of priority effects with respect to coinfections is still in its infancy. Moreover, existing coinfection studies typically focus on infection outcomes associated with exposure to distinct sets of parasite species, despite that functionally and morphologically similar parasite species commonly coexist in nature. Therefore, it is important to understand how interactions between similar parasites influence infection outcomes. Surveys at seven ponds in northwest Pennsylvania found that multiple species of echinostomes commonly co-occur. Using a larval anuran host (Rana pipiens) and the two most commonly identified echinostome species from our field surveys (Echinostoma trivolvis and Echinoparyphium lineage 3), we examined how species composition and timing of exposure affect patterns of infection. When tadpoles were exposed to both parasites simultaneously, infection loads were higher than when exposed to Echinoparyphium alone but similar to being exposed to Echinostoma alone. When tadpoles were sequentially exposed to the parasite species, tadpoles first exposed to Echinoparyphium had 23% lower infection loads than tadpoles first exposed to Echinostoma. These findings demonstrate that exposure timing and order, even with similar parasites, can influence coinfection outcomes, and emphasize the importance of using molecular methods to identify parasites for ecological studies.
Effect of alcohol use disorder family history on cognitive function
Authors: Khemiri Lotfi , Franck Johan , Jayaram-Lindström Nitya
Published: July 2020

Background

Alcohol use disorder (AUD) is associated with cognitive deficits but little is known to what degree this is caused by genetically influenced traits, i.e. endophenotypes, present before the onset of the disorder. The aim of the current study was to investigate to what degree family history (FH) of AUD is associated with cognitive functions.

Methods

Case-control cross-sectional study at an outpatient addiction research clinic. Treatment-seeking AUD patients (n = 106) were compared to healthy controls (HC; n = 90), matched for age and sex. The HC group was further subdivided into AUD FH positive (FH+; n = 47) or negative (FH−; n = 39) based on the Family Tree Questionnaire. Participants underwent psychiatric and substance use assessments, completed the Barratt Impulsiveness Scale and performed a comprehensive battery of neuropsychological tests assessing response inhibition, decision making, attention, working memory, and emotional recognition.

Results

Compared to HC, AUD patients exhibited elevated self-rated impulsivity (p < 0.001; d = 0.62), as well as significantly poorer response inhibition (p = 0.001; d = 0.51), attention (p = 0.021; d = 0.38) and information gathering in decision making (p = 0.073; d = 0.34). Similar to AUD patients, FH+ individuals exhibited elevated self-rated impulsivity (p = 0.096; d = 0.46), and in addition significantly worse future planning capacity (p < 0.001; d = 0.76) and prolonged emotional recognition response time (p = 0.010; d = 0.60) compared to FH−, while no other significant differences were found between FH+ and FH−.

Conclusions

Elevated impulsivity, poor performance in future planning and emotional processing speed may be potential cognitive endophenotypes in AUD. These cognitive domains represent putative targets for prevention strategies and treatment of AUD.
Effects of semantic plausibility, syntactic complexity and n-gram frequency on children's sentence repetition
Authors: POLIŠENSKÁ Kamila , CHIAT Shula , SZEWCZYK Jakub , TWOMEY Katherine E.
Published: July 2020

Theories of language processing differ with respect to the role of abstract syntax and semantics vs surface-level lexical co-occurrence (n-gram) frequency. The contribution of each of these factors has been demonstrated in previous studies of children and adults, but none have investigated them jointly. This study evaluated the role of all three factors in a sentence repetition task performed by children aged 4–7 and 11–12 years. It was found that semantic plausibility benefitted performance in both age groups; syntactic complexity disadvantaged the younger group but benefitted the older group; while contrary to previous findings, n-gram frequency did not facilitate, and in a post-hoc analysis even hampered, performance. This new evidence suggests that n-gram frequency effects might be restricted to the highly constrained and frequent n-grams used in previous investigations, and that semantics and morphosyntax play a more powerful role than n-gram frequency, supporting the role of abstract linguistic knowledge in children's sentence processing.
On different load configurations for mixed-mode load-pull measurements, hybrid imperfections, and tuning ranges
Authors: Veit David , Gadringer Michael , Leitgeb Erich
Published: July 2020

Each of the various methods for mixed-mode load-pull measurements, which can be found in literature, has its own advantages and disadvantages. In this publication, we analyze two of the most commonly used setups and a third setup of which we provided an initial treatment in a previous publication. We investigated the impact of 180° hybrids on the tuning capabilities of a mixed-mode load-pull system. Furthermore, we provide a rule-of-thumb to easily estimate this impact using only some specifications of hybrids. For all analyzed setups, we use measurement results to show that the tuning range of the newly proposed setup is superior compared to the other setups, though hardware effort and tuning complexity are greater.
Miniature drone antenna design for the detection of airliners
Authors: Sidibe Alassane , Loubet Gaël , Takacs Alexandru , Ferré Guillaume , Ghiotto Anthony
Published: July 2020

In this paper, the design of a miniature antenna dedicated to the detection of airliners through the demodulation of Automatic Dependence Surveillance-Broadcast system (ADS-B) signals is presented. This antenna is designed for being embedded on the top of a drone in order to detect and avoid collisions with airliners. This antenna consists of an array of Planar Inverted-F Antennas, a quadrature feed network (FN) and a reflector plane (RP). The FN is designed to have output signals with the same amplitude and a 90° phase difference between each other. It achieves circular polarization and maintains the axial ratio of the antenna under −3 dB at the desired frequency (1.09 GHz). The antenna with the FN was manufactured and characterized. It weighs approximately 145 kg with its RP. The measured gain of the proposed antenna is about +3.7 dBi. To validate the design, the manufactured antenna was tested with a Universal Software Radio Peripheral for the processing of ADS-B signals at the French National Microwaves Days 2019 (JNM) student contest. The detection of airliners can reach up to 437 km.
Insulin sensitivity in male sheep born to ewes treated with testosterone during pregnancy
Authors: Carrasco Albert , Recabarren Mónica P. , Rojas-García Pedro P. , Silva Nelson , Fuenzalida Jonathan , Sir-Petermann Teresa , Recabarren Sergio E.
Published: July 2020

In animal models, exposure to excess testosterone during gestation induces polycystic ovary syndrome (PCOS)-like reproductive and metabolic traits in female offspring, suggesting that the hyperandrogenemic intrauterine environment may have a role in the etiology of PCOS. Additionally, few studies have also addressed metabolic and reproductive outcomes in male offspring. In the present study, the intravenous glucose tolerance test (IGTT) was used to assess the insulin–glucose homeostasis at various ages during sexual development in male sheep born to testosterone-treated ewes. To further analyze the programming effect of testosterone on insulin–glucose homeostasis, indexes of insulin sensitivity were assessed in orchidectomized post-pubertal males born to testosterone-treated ewes (Torq-males) and orchidectomized post-puberal controls (Corq-males) before and 48 h after a testosterone injection. There was no difference in insulin sensitivity indexes between males born to testosterone-treated ewes (T-males) and control males born to control ewes (C-males) at 5, 10, 20 and 30 weeks of age, representing the infantile, early and late pre-pubertal, and early post-pubertal stage of sexual development, respectively. In orchidectomized males, basal levels of insulin and glucose were not different between both groups before and after the testosterone injection; however, Torq-males released more insulin before and after T challenge during the first 20 min of the test. Despite this, plasma glucose concentrations were not different in both groups during IVGTT, resulting in an insulin sensitivity index composite similar between groups. We concluded that the effect of prenatal exposure to excess testosterone may reprogram the pancreatic β-cells insulin release in ovine males, with effects more evident in castrated males versus intact males.
The Costs of Conflict and Support for the Use of Force: Accounting for Information Equivalence in Survey Experiments
Authors: McDonald Jared , Walsh James Igoe
Published: July 2020

How do the costs of conflict influence public support for the use of force? Existing research finds that weapons that eliminate the possibility of military casualties, such as drones, increase popular support for engaging in conflict. We argue that this effect may be overstated because the choice of weapons technology is endogenous to conflict. Leaders may select to use drones in conflicts where the risk of harm to ground forces is especially high. To address this, we replicate and extend the research design of Walsh and Schulzke across three survey experiments. The key innovation in our experiments is that subjects are led to believe that the choice of attack type – drones or ground troops – is determined by weather conditions rather than strategic considerations. We find that support for military action does not differ across treatments in which subjects are told that the attack involves drone strikes or ground troops.
Rad50 mediates DNA demethylation to establish pluripotent reprogramming
Authors: Park Hanseul , Cho Byounggook , Kim Jongpil
Published: July 2020

DNA demethylation is characterized by the loss of methyl groups from 5-methylcytosine, and this activity is involved in various biological processes in mammalian cell development and differentiation. In particular, dynamic DNA demethylation in the process of somatic cell reprogramming is required for successful iPSC generation. In the present study, we reported the role of Rad50 in the DNA demethylation process during somatic cell reprogramming. We found that Rad50 was highly expressed in pluripotent stem cells and that Rad50 regulated global DNA demethylation levels. Importantly, the overexpression of Rad50 resulted in the enhanced efficiency of iPSC generation via increased DNA demethylation, whereas Rad50 knockdown led to DNA hypermethylation, which suppressed somatic cell reprogramming into iPSCs. Moreover, we found that Rad50 associated with Tet1 to facilitate the DNA demethylation process in pluripotent reprogramming. Therefore, our findings highlight the novel role of Rad50 in the DNA demethylation process during somatic cell reprogramming.
NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90
Authors: Chen Wenwen , Wang Wei , Sun Xiaoxia , Xie Shanshan , Xu Xiaoyang , Liu Min , Yang Chunxia , Li Min , Zhang Wen , Liu Wei , Wang Liangjing , Zhou Tianhua , Yang Yuehong
Published: July 2020

Cell migration plays pivotal roles in many biological processes; however, its underlying mechanism remains unclear. Here, we find that NudC-like protein 2 (NudCL2), a cochaperone of heat shock protein 90 (Hsp90), modulates cell migration by stabilizing both myosin-9 and lissencephaly protein 1 (LIS1). Either knockdown or knockout of NudCL2 significantly increases single-cell migration, but has no significant effect on collective cell migration. Immunoprecipitation–mass spectrometry and western blotting analyses reveal that NudCL2 binds to myosin-9 in mammalian cells. Depletion of NudCL2 not only decreases myosin-9 protein levels, but also results in actin disorganization. Ectopic expression of myosin-9 efficiently reverses defects in actin disorganization and single-cell migration in cells depleted of NudCL2. Interestingly, knockdown of myosin-9 increases both single and collective cell migration. Depletion of LIS1, a NudCL2 client protein, suppresses both single and collective cell migration, which exhibits the opposite effect compared with myosin-9 depletion. Co-depletion of myosin-9 and LIS1 promotes single-cell migration, resembling the phenotype caused by NudCL2 depletion. Furthermore, inhibition of Hsp90 ATPase activity also reduces the Hsp90-interacting protein myosin-9 stability and increases single-cell migration. Forced expression of Hsp90 efficiently reverses myosin-9 protein instability and the defects induced by NudCL2 depletion, but not vice versa. Taken together, these data suggest that NudCL2 plays an important role in the precise regulation of cell migration by stabilizing both myosin-9 and LIS1 via Hsp90 pathway.