bluuebunny/crossref_metadata_2025 huggingface dataset:
BALITUNG PUTRA DAERAH YANG SUKSES MENJADI RAJA MATARAM KUNA
Authors: Tjahjono Baskoro Daru
Published: May 2019

Balitung was not a direct descendent of Çailendra dynasty – royal family who ruled Old Mataram Kingdom. He was a prince from Watukura (South Kedu). His title showed his origins – Rakai Watukura Dyah Balitung.Before mounted the throne of Old Mataram he was a Rakai in Watak Watukura. which is titled haji. Watak Watukura is a part of Old Mataram region which was located far from the capital city. Therefore Balitung is a native of Watukura region.Balitung became a king of Old Mataram because of his marriage to Rakai Watuhumalang’s daugter, a ruler of Mataram before him. Mantyasih inscription mentioned his title as haji or a subordinat ruler. But as a king, he was succeeded to expand the territory of Old Mataram and became one of the famous kings. A large number of inscription were published by him. The distribution of his inscription covered a vast territory, including Central and East Java.
Синтез, физико-химические свойства и противомикробная активность конъюгатов полимиксина B1 с полиглутаровым альдегидом
Authors: Шалыгина Виолетта В. , Власова Елена Н. , Ананьева Елена П. , Гайдукова Виктория А.
Published: May 2019

По реакции восстановительного аминирования синтезированы конъюгаты полимиксина B1 с полиглутаровым альдегидом. Синтезированные полимерные производные антибиотика протестированы на антимикробную активность по отношению к грамотрицательным и грамположительным бактериям. Установлено, что полимиксин B1 стабилен в условиях реакции и основными структурными факторами, влияющими на антимикробную активность конъюгатов, являются их состав и строение полимерной цепи полиглутарового альдегида. Конъюгаты полимер — антибиотик хорошо растворимы в водных растворах и в органических растворителях.
Квантово-химическое моделирование десорбции винпоцетина с поверхности частиц кремния и диоксида кремния
Authors: Полковникова Юлия Александровна , Леньшин Александр Сергеевич , Сливкин А. И.
Published: May 2019

Проведен сравнительный анализ энергии активации десорбции винпоцетина с поверхности кремния и диоксида кремния. Установлено, что молекулярный механизм десорбции винпоцетина отличается в зависимости от адсорбента и состояния ионизации, которое в свою очередь зависит от величины pH. При десорбции с гидрофобной поверхности кремния без заместителей определяющую роль в процессе десорбции играют неполярные взаимодействия между адсорбентом и винпоцетином. На основе квантово-химической оценки энергии активации можно сделать вывод о более прочном связывании винпоцетина с оксидом кремния в водной среде при pH 6,8 и 7 по сравнению с кремнием. При pH 2 энергии активации десорбции винпоцетина с поверхности кремния и оксида кремния статистически неразличимы и имеют статистически меньшие значения по сравнению с энергиями активации при pH 6,8 и 7.
Количественное определение рибавирина спектрофотометрическим методом
Authors: Киенская Карина Игоревна , Ильюшенко Екатерина В. , Сардушкин Макар Владимирович , Гузнова Наталья Юрьевна , Колдаева Т. Ю. , Кусмаев А. М. , Ибрагимова Римма Рамильевна , Белова И. А. , Кухаренко А. В. , Шапошникова Л. И. , Завьялова О. В. , Авраменко Григорий Владимирович
Published: May 2019

Предложена методика количественного определения рибавирина методом УФ-спектрофотометрии. В валидационных испытаниях доказана пригодность методики. Показана возможность спектрофотометрического определения рибавирина в таблетках.
Гиполипидемическое действие экстрактов лекарственных растений при экспериментальном сахарном диабете
Authors: Венгеровский Александр Исаакович , Якимова Татьяна Витальевна , Насанова Очирма Насаковна
Published: May 2019

При экспериментальном сахарном диабете, вызванном у крыс стрептозотоцином и диетой с высоким (30 %) содержанием жиров, водные экстракты листьев крапивы двудомной (100 мг/кг) и корней лопуха большого (25 мг/кг) уменьшали в крови содержание глюкозы, триглицеридов, общего холестерина, липопротеинов низкой и очень низкой плотности, повышали содержание холестерина и белка липопротеинов высокой плотности, препятствовали окислению липопротеинов низкой плотности, гликозилированию белков липопротеинов высокой плотности и гемоглобина. Гиполипидемическое действие растительных экстрактов не уменьшалось при кормлении животных пищей с высоким содержанием жиров. Росиглитазон проявлял более значительные гипогликемический и гиполипидемический эффекты на фоне диеты с низким содержанием жиров. В составе экстрактов крапивы и лопуха противодиабетическое действие оказывают флавоноиды и каротиноиды.
Количественное определение производного гамма-аминомасляной кислоты мефебута в биологических пробах методом ВЭЖХ
Authors: Смирнова Людмила Андреевна , Рябуха Анна Федоровна , Сучков Евгений Александрович , Кузнецов Константин Александрович , Тюренков Иван Николаевич , Бакулин Дмитрий Александрович
Published: May 2019

Разработан метод ВЭЖХ количественного определения для проведения фармакокинетического анализа мефебута. Метод высокочувствителен и селективен и может быть использован для определения в биологическом материале. Способ пробоподготовки подобран оптимально и не оказывает значимого влияния на среднюю ошибку измерения хроматографического метода количественного определения.
PATEN TERHADAP APLIKASI PROGRAM KOMPUTER BERBASIS FINANCIAL AND TECHNOLOGY DI INDONESIA
Authors: Marfistasari Anik , Kurniawati Ennys , Indraswati Badzlina Putri
Published: May 2019

Patents as Intellectual Property Rights which are included in exclusive rights that contain legal construction. It basically must provide legal protection for the application of financial and techology-based on computer programs in Indonesia, where it is given to the novelty of the invention, inventive steps contained in it; and the success of inventions that should be applicable in industries that are developing at this time. To get tsshe assurance and legal protection against fintech programs invention, it is necessary to be followed up on legislation in the field of intellectual property, especially in terms of special patents which it related the fintceh programs inventions in Indonesia, which are expected to provide solutions to the legal problems in Indonesia and to provide a clear legal direction related the fintech programs inventions, on the other hand, with the existence of the legislation in the field of special patent it is expected that can obtain balanced legal protection related to computer programs. Which must be in accordance with the purpose of the invention itself to support the maximum efforts to achieve people's welfare .
PERTANGGUNGJAWABAN PIDANA ATAS PENYALAHGUNAAN PEMBAYARAN BEA PEROLEHAN HAK ATAS TANAH DAN BANGUNAN (BPHTB) OLEH PEJABAT PEMBUAT AKTA TANAH (PPAT)
Authors: Nisya’ Intifada Atin
Published: May 2019

This journal is entitled as Criminal Liability for Misappropriation Payments for the Acquisition of Land and Building Rights (BPHTB) by Official Certifier of Title Deeds (PPAT). Normative juridical legal research was applied in this study. The approach used in this problem is the legal approach (statute approach), case approach (case approach), and conceptual approach (conceptual approach).

            The background study of this thesis is about the problem for the notary as the Official Certifier of Title Deeds / Land Deed Official (PPAT) who is involved in a criminal act. There are several cases of tax evasion and also fictitious tax invoices. One of the cases in this case is the PPAT in Semarang, which ended is subject to criminal acts of Corruption. It was proved by the tax payment money when he should have paid the tax but not paid and she did some data manipulation to enrich himself. In order to establish an action as a violation against the law, the loss of state finances or just against the law has an item belonging to another person in his power, where the goods are not from the proceeds of crime. Based on this background, there are two main issues, namely How does the Ratio Decide in court decisions related to cases of misuse of BPHTB payments made by PPAT and What is the validity of the sale and purchase deed if BPHTB tax invoice and PPh (final) falsified?
KEDUDUKAN HUKUM AKTA JAMINAN FIDUSIA YANG TIDAK DIDAFTARKAN
Authors: Huru Fince Ferdelina
Published: May 2019

One of the features of the fiduciary guarantee is the executorial nature of the fiduciary guarantee on the fiduciary guarantee certificate. To obtain these rights, the guarantee must be registered with the Fiduciary Guarantee Registration Office. But in its implementation, there are still many fiduciary guarantees that are not registered with the Fiduciary Registration Office. This study analyzes the legal consequences of fiduciary guarantees that are not registered and legal protection to creditors if the Fiduciary deed is not registered. The research method used is normative legal research, namely legal research conducted by examining library materials or secondary legal material while the problem approach is carried out using a legal approach and conceptual approach. The results of the study show that the legal consequences of fiduciary guarantee deeds, which have no legal force at all in carrying out executions and against objects of fiduciary guarantee do not give birth to material rights inherent in fiduciary guarantees. As a result of not registering a fiduciary deed, there is no legal protection at all for creditors
PENGARUH SIKAP BELANJA ONLINE TERHADAP TRUST MELALUI MEDIATOR KEPUASAN PELANGGAN
Authors: Selviana  , Setyowati Retno Budi
Published: May 2019

Technological advances are increasingly developing, making the internet not only used forcommunication and information sources, but also as an electronic trading medium or betterknown as e-commerce (electronic commerce). In e-commerce, many products are sold andpurchased online at prices that can compete with store prices. Easy transaction processesthat can be done anytime and anywhere and the price of goods is more affordable, making ecommercea shopping option. Therefore, through this research the researcher wants to knowthe attitude of online shopping towards trusts through customer satisfaction mediators.Research respondents were people who had been shopping online on the Indonesian networkand used it themselves. The number are 184 people with accidental sampling technique. Datacollection using the google.docs questionnaire which was distributed through Whats up anddata analysis using path analysis with the Lisrel program. The results of the analysis showthat there is an influence of online shopping attitudes towards trusts through customersatisfactionmediators.
Recent Experimental Work on ‘Ought’ Implies ‘Can’
Authors: Semler Jen , Henne Paul
Published: May 2019

While philosophers generally accept some version of the principle ‘ought’ implies ‘can’, recent work in experimental philosophy and cognitive science provides evidence against a presupposition or a conceptual entailment from ‘ought’ to ‘can’. Here, we review some of this evidence, its effect on particular formulations of the principle, and future directions for cognitive scientists and philosophers.
Kompetensi Pengawas Supervisi Pendidikan pada SMP di Semarang
Authors: Roza Nelfa
Published: May 2019

Dua hal yang harus dimiliki oleh seorang pengawas sekolah yaitu kualifikasi dan kompetensi.Tanggung jawab seorang pengawas sekolah adalah meningkatkan kualitas proses belajarmengajar dan hasil belajar siswa dalam rangka pencapaian tujuan pendidikan, terlebih pada eraglobalisasi saat ini tuntutan seorang pengawas sekolah menjadi lebih berat. Tujuan yang ingindicapai dalam artikel yang saya kutip adalah mengetahui gambaran pengawas dalam supervisiakademik pada SMP di kota semarang. Hasil penelitian diperoleh beberapa temuan penilaianterhadapa kompetensi pengawas sekolah dalam supoervisi akadenmik yaitu terkait dengan (1)pembimbingan kepala sekolah pada tiap mata pelajaran dari rumpun mata pelajaran yangrelevan, (2) berkenaan dengan tugasnya untuk membimbing guru dalam menyusun silabus tiapmata pelajaran berdasarkan pengembangan KTSP, (3) pembimbing dalam melaksanakankegiatan pembelajaran/bimbingan (di kelas, laboraturium, dan atau di lapangan) untuk tiapmata pelajaran dalam rumpun mata pelajaran yang relevan. Berdasarkan bebrapa temuantersebut perlu diacari solusinya, agar hubungan antara supervisor dan supervisee dapat berjalandengan lancar tanpa ada hambatan, melalui penilaian multirater (berdasarkan teori 360 degreefeedback). Harapannya agar pengawas sekolah mengetahui kekurangan dan adanya perbaikandi masa depan.
A Solution for Dynamic Spectrum Management in Mission-Critical UAV Networks
Authors: Shamsoshoara Alireza
Published: May 2019

In this paper, we study the problem of spectrum scarcity in a network of unmanned aerial vehicles (UAVs) during mission-critical applications such as disaster monitoring and public safety missions, where the pre-allocated spectrum is not sufficient to offer a high data transmission rate for real-time video streaming. In such scenarios, the UAV network can lease part of the spectrum of a terrestrial licensed network in exchange for providing relaying service. In order to optimize the performance of the UAV network and prolong its lifetime, some of the UAVs will function as a relay for the primary network while the rest of the UAVs carry out their sensing tasks. Here, we propose a team reinforcement learning algorithm performed by the UAV's controller unit to determine the optimum allocation of sensing and relaying tasks among the UAVs as well as their relocation strategy at each time. We analyze the convergence of our algorithm and present simulation results to evaluate the system throughput in different scenarios.
Pengawasan supervisi akademik pada SMP di Semarang
Authors: Roza Nelfa
Published: May 2019

Dua hal yang harus dimiliki oleh seorang pengawas sekolah yaitu kualifikasi dan kompetensi. Tanggung jawab seorang pengawas sekolah adalah meningkatkan kualitas proses belajar mengajar dan hasil belajar siswa dalam rangka pencapaian tujuan pendidikan, terlebih pada era globalisasi saat ini tuntutan seorang pengawas sekolah menjadi lebih berat. Tujuan yang ingin dicapai dalam artikel yang saya kutip adalah mengetahui gambaran pengawas dalam supervisi akademik pada SMP di kota semarang. Hasil penelitian diperoleh beberapa temuan penilaian terhadapa kompetensi pengawas sekolah dalam supoervisi akadenmik yaitu terkait dengan (1) pembimbingan kepala sekolah pada tiap mata pelajaran dari rumpun mata pelajaran yang relevan, (2) berkenaan dengan tugasnya untuk membimbing guru dalam menyusun silabus tiap mata pelajaran berdasarkan pengembangan KTSP, (3) pembimbing dalam melaksanakan kegiatan pembelajaran/bimbingan (di kelas, laboraturium, dan atau di lapangan) untuk tiap mata pelajaran dalam rumpun mata pelajaran yang relevan. Berdasarkan bebrapa temuan tersebut perlu diacari solusinya, agar hubungan antara supervisor dan supervisee dapat berjalan dengan lancar tanpa ada hambatan, melalui penilaian multirater (berdasarkan teori 360 degree feedback). Harapannya agar pengawas sekolah mengetahui kekurangan dan adanya perbaikan masa depan.
Teachers versus Extension Agents from Education Perspective
Authors: Budiaji Weksi
Published: May 2019

Teachers are educators that educate people in formal educations, namely elementary and secondary levels. They have a formal qualification. Meanwhile, extension agents work in informal education. Teachers and extension agents have differences in their targeted participants, materials, and education approach. The targeted participants of teachers are students having specific level while the extension agents have adult farmers, breeders, and fishermen. Teachers educate and teach good models or examples using their professional activities that is pedagogic approach. They opt of the method depending on the class level in line with the education and curriculum goals. Because they teach using determined curriculum, they are independent from any conflict of interests. On the other hand, extension agents not only educate and teach, but also drive and motivate the participants using adult education approach. They disseminate recommended innovation to the participants and persuade them using particular methods and techniques based on the participants’ knowledge, stance, geographical location and needs so that they are voluntary adopt the innovation. Both teachers and extension agents share similarity in their missions, teaching and educating people. (citation: Budiaji, W., Mulyaningsih, A., and Mulyani, S. 2014. Proceeding of International Seminar on Education 2014, pp 161-165, May 03 2014.)
Space and Memory (far) beyond the Hippocampus: Many Subcortical Structures also Support Cognitive Mapping and Mnemonic Processing
Authors: O'Mara Shane , Aggleton John
Published: May 2019

Memory research remains focused on just a few brain structures – in particular, the hippocampal formation (the hippocampus and entorhinal cortex). Three key discoveries promote this continued focus: the striking demonstrations of enduring anterograde amnesia after bilateral hippocampal damage; the realisation that synapses in the hippocampal formation are plastic e.g., when responding to short bursts of patterned stimulation (‘long-term potentiation’ or LTP); and the discovery of a panoply of spatially-tuned cells, principally surveyed in the hippocampal formation (place cells coding for position; head-direction cells, providing compass-like information; and grid cells, providing a metric for 3D space). Recent anatomical, behavioural, and electrophysiological work extends this picture to a growing network of subcortical brain structures (including the anterior thalamic nuclei, rostral midline thalamic nuclei, and the claustrum). There are, for example, spatially-tuned cells in all of these regions, including cells with properties similar to place cells of the hippocampus proper. These findings add new perspectives to what had been originally been proposed - but often overlooked - half a century ago: that damage to an extended network of structures connected to the hippocampal formation results in diencephalic amnesia. We suggest these new findings extend spatial signalling in the brain far beyond the hippocampal formation, with profound implications for theories of the neural bases of spatial and mnemonic functions.
Mapping visual features onto numbers
Authors: Brockbank Erik , Vul Edward
Published: May 2019

Modern society frequently requires that we express our subjective senses in objective, shared formal systems; this entails mapping multiple internal variables onto a common scale. Here we ask whether we accomplish this feat in the case of estimating number by learning a single mapping between explicit numbers and one integrated subjective estimate of numerosity, or if we separately map different perceptual features onto numbers. We present people with arrays of dots and ask them to report how many dots there are; we rely on the systematic under/overestimation of number at higher quantities to estimate error in the mapping function. By comparing how this error changes over time, as the mapping fluctuates for different visual cues to numerosity, we can evaluate whether these cues share a single mapping, or are mapped onto number individually. We find that area, size, and density all share a common mapping, indicating that people obtain a unified subjective estimate of numerosity before mapping it onto the formal number line.
What information shapes and shifts people’s attitudes about capital punishment?
Authors: Miske Olivia Anne , Schweitzer Nicholas , Horne Zachary
Published: May 2019

Although most Americans support capital punishment, many people have misconceptions about its efﬁcacy and administration (e.g., that capital punishment deters crime). Can correcting people’s inaccurate attitudes change their support for the death penalty? If not, are there other strategies that might shift people’s attitudes about the death penalty? Some research suggests that statistical information can correct misconceptions about polarizing topics. Still, statistics might be irrelevant for some people because they may support capital punishment for purely retributive reasons, suggesting other argumentative strategies may be more effective. In Studies 1 and 2, we examined what attitudes shape endorsement of capital punishment and compared how two different interventions shifted these attitudes. Altogether, our ﬁndings suggest that attitudes about capital punishment are based on more than just retributive motives, and that correcting misconceptions related to its administration reduces support for capital punishment.
Computational observation: Challenges and opportunities of automated observation within algorithmically curated media environments using a browser plug-in
Authors: Haim Mario , Nienierza Angela
Published: May 2019

A lot of modern media use is guided by algorithmic curation, a phenomenon that is in desperate need of empirical observation, but for which adequate methodological tools are largely missing. To fill this gap, computational observation offers a novel approach—the unobtrusive and automated collection of information encountered within algorithmically curated media environments by means of a browser plug-in. In contrast to prior methodological approaches, browser plug-ins allow for reliable capture and repetitive analysis of both content and context at the point of the actual user encounter. After discussing the technological, ethical, and practical considerations relevant to this automated solution, we present our open-source browser plug-in as an element in an adequate multi-method design, along with potential links to panel surveys and content analysis. Ultimately, we present a proof-of-concept study in the realm of news exposure on Facebook; we successfully deployed the plug-in to Chrome and Firefox, and we combined the computational observation with a two-wave panel survey. Although this study suffered from severe recruitment difficulties, the results indicate that the methodological setup is reliable and ready to implement for data collection within a variety of studies on media use and media effects.
Cutaneous Manifestations of Thyroid Hormone Disorder
Authors: Sijapati Karuna Singh , Rijal Arpana , Agrawal Sudha , Khadka Dhan Keshar , Maskey Robin
Published: May 2019

Introduction: Thyroid hormone disorder (THD), a major health problem, is associated with a wide range of diseases. One of the organs, which  shows this wide range of clinical signs is the skin. Some dermatological findings may be the first symptoms of THD. Therefore, this study was planned to determine various cutaneous manifestations of THD that can be used as a diagnostic marker for THD. In Nepal due to lack of awareness, thyroid diseases may go unnoticed .So, cutaneous manifestations help in early diagnosis and treatment of THD.

Objectives: To identify cutaneous manifestations of THD and to evaluate dermatological manifestations specific for THD. 

Materials and methods: Seventy six patients with diagnosis of THD attending endocrine clinic of Internal Medicine Department in BPKIHS, Dharan were consecutively assessed for cutaneous changes by detailed history and clinical examination. As a control group, 26 age and  sex matched individuals without THD were included to assess frequency of cutaneous manifestation in normal individuals. 

Results: Fifty five (72.3%) cases and 4(15.4%) control had skin changes. This observation was statistically significant with OR-14.4(95% CI4.43 – 46.78) and p<0.001.Hair changes (OR-2.100, 95% CI 0.647-6.821 and p=0.210) and nail changes (OR-1.818, 95% CI 0.371-8.902 and p=0.726) had no statistically significant association with THD.

Conclusion: THD may present as or be associated with many changes in skin, hair and nails.
Clinico-epidemiological Profile of Women with Non-venereal Vulval Diseases: A Hospital-based Observational Study
Authors: Joshi Smita , Shrestha Shristi , Joshi Anshumala
Published: May 2019

Intorduction: Vulval disorders can be of venereal and non-venereal etiology. Establishing non-venereal causation of vulval disorder helps in alleviating fears in patients with the condition. These patients are better dealt in a multidisciplinary clinic as patients with these disorders frequently visit dermatologists and gynecologists for the treatment.

Objectives: To study the clinico-demographic profile of women with non-venereal vulval disorders and to determine their relative frequency.

Materials and Methods: This is an observational, descriptive study done at the Departments of Dermatology and Venereology and Gynecology and Obstetrics, Nepal Medical College Teaching Hospital. All consenting female patients with problems pertaining to female external genitalia were recruited for the study after excluding venereal diseases. Details of the patients were obtained and entered in a predesigned proforma.

Results: Seventy-five females were recruited during a period of 20 months with a mean age of 34.79±17.90 years. Majority were married, uneducated and homemakers. Duration of disease ranged from 3 days to 35 years. Itching was the commonest presenting complaint (82.67%) followed by redness (32.00%), burning sensation (26.67%), white lesions (24.00%) and pain (24.00%). Commonest diagnosis was lichen sclerosus (17.33%), followed by candidiasis (14.67%). Patients presenting with vulval symptoms without lesions were diagnosed with non-specific vulval pruritus (9.33%) and vulvodynia (2.67%).

Conclusion: Itching is the most common presenting complaint and contrary to the popular belief, inflammatory disorders especially lichen sclerosus, rather than infections were common diagnoses in females with non-venereal vulval disorders.
Profile of Clients of HIV Testing and Counseling in a Tertiary Care Center and Need of Testing in Tuberculosis
Authors: Shrestha Smriti , Karn Dharmendra , Tamrakar Dipesh , Madhup Surendra , Karmacharya Biraj Man
Published: May 2019

Introduction: Sexually transmitted infection is public health issue that amplifies HIV burden globally. At National Center of AIDS and STD Control, annual reported STI are rising steeply recently. Incidence of HIV is 0.03% while prevalence in adult population is less than 1%. National HIV testing guidelines 2017 recommends HIV tests should be performed in tuberculosis and medical conditions. However, it is not routinely done in Nepal.

Objective: To assess profile of STI and HIV among patients attending HIV testing and counseling center of tertiary hospital, and to assess fraction of tuberculosis patients undergoing HIV testing.

Materials and Methods: All patients attending HIV testing and counseling center were tested for HIV. Tests for STI were done based on patient symptoms. Data collected were analyzed with SPSS.

Results: Suspected STI (41.1%) was commonest cause of HIV testing. Among STI, gram positive diplococcic were noted in 11.5% and 3.4% had PCR positive Chlamydia. Only 19.4% (7 out of 36) of total tuberculosis patients in hospital were screened for HIV, among which, 57.14% (4 out of 7) were seropositive for HIV, which is noteworthy.

Conclusion: Our study shows patterns of STI, and that gonorrhea and chlamydia could be underdiagnosed in Nepal. Every patient with tuberculosis should routinely be screened for HIV. But only small fraction of tuberculosis patients underwent HIV screening, out of which HIV positivity was high, reflecting the gap and need for routine HIV screening in TB patients.
Efficiency of meloxicam application in complex treatment of patients with osteoarthrosis combined with hypertension
Authors: Kuznecova L P , Bondar M. V.
Published: May 2019

Objective: To evaluate the efficacy of the therapy performed 12 months after initiation of treatment in patients with osteoarthrosis (OA) combined with hypertension (GC) with treatment with meloxicam at a dose of 7.5 mg/day and 80 mg/day and 160 mg/day "difores".

Materials and methods: under observation in outpatient settings, there were 60 patients on OA 1–2 stages, in combination with GC 2 degree, 2–3 degrees. The average age of patients with OA was 64.4 ± 7.5 years, patients with OA in combination with GC – 62.13 ± 8.2 years – 41 (68.3 %) women and 19 (31.7 %) men. Duration of the disease was in patients with OA – (9.66 ± 4.7) years, in patients with a comorbidity of OA and GC – (9.4 ± 6.0) years, respectively.

To perform the research tasks, all patients were divided into 3 groups of 30 patients in each of them. The first group – patients with OA without GC, the second one – patients with a combination of OA and GC, the third group of comparison contained practically healthy persons.

All patients complained of pain syndrome of varying degrees of severity. Patients of the first two groups received methoxy at a dose of 7.5 mg per day as baseline therapy; meloxicam and antihypertensive drug "diforsi" at a dose of 80 mg per day – patients in the second group were taken, but in 29 % of patients in this group "diormos" was prescribed at a dose of 160 mg. Duration of treatment was 12 months.

A general clinical examination was performed inall patients at the beginning of the study, and after treatment: general blood tests, office blood pressure measurements, electrocardiography (ECG), daily blood pressure monitoring (DMAT), radiography of the knee joints.

Results:

According to the results, the positive effect of using meloxicam caused a significant decrease in the severity of pain in the first and second groups according to the visual analog scale (VAS): (by 27.8 % and 29.8 % respectively, p < 0.05) and the Lequesne index (respectively 27.1 % and 30.9 %, p < 0.05).

Also, the analgesic and anti-inflammatory effect of meloxicam and its positive effect on the clinical course of OA were revealed: joint pain decreased, functional capacity in-creased, general well-being and quality of life of patients improved.
Primary headache associated with sexual activity
Authors: Білошицький В В
Published: May 2019

Пацієнт, 48 років, звернувся зі скаргами на приступи інтенсивного головного болю, що виникає під час оргазму. Уперше такий приступ виник за 13 днів до консультації під час статевого акту з новою партнеркою, який супроводжувався значним сексуальним збудженням. Напад повторився через 3 дні під час наступного статевого акту і ще за 6 днів після другого. Відчуття болю з’являється в лівій потиличній ділянці голови, інтенсивність зростає протягом 3 секунд, допоки не виникає надзвичайно сильний біль (VAS 8–9), який при розпитуванні пацієнт характеризує як найсильніший у житті («наче лусне голова»). Біль локалізується в лівій потилично-скроневій ділянці з відчуттям «тиску на очі». Інтенсивний біль тривав 1,5–2 хвилини, потім його вираженість зменшувалася до VAS 3, і такий остаточний біль зберігався до 1,5 години. На початку на-паду пацієнт приймав 2 таблетки спазмалгону (метамізол натрію моногідрат, пітофенону гідрохлорид, фенпіверинію бромід).Головний біль не супроводжується нудотою, фото- й фонофобією. Також немає вегетативних проявів, характерних для тригемінальних вегетативних цефалгій (ін’єкція кон’юнктиви та/або сльозотеча, закладення носа та/або ринорея, набряк повік, потіння лоба та обличчя, почервоніння лоба та обличчя, відчуття закладення вуха, міоз та/або птоз).Під час третього нападу пацієнт, відчувши «пульсацію в голові», зменшив активність і рівень збудження, внаслідок чого біль не сягнув вище рівня VAS 4 і згодом припинився. Пацієнт зазначає, що замолоду мав один епізод головного болю (не пов’язаного з сексуальною активністю), що тривав кілька днів. Із 35-річного віку з’явилися головні болі тієї ж локалізації (ліва потилично-скронева ділянка), тупі, низької інтенсивності (VAS 3), які виникають при фізичних навантаженнях, особливо пов’язаних із нахилами («качання черевного преса» – не більше 15 нахилів, робота на городі – сапання).При нападах інтенсивного головного болю, що настають вибухоподібно, у тому числі при першому нападі головного болю, пов’язаного з сексуальною активністю, завжди слід виключати такі види патології, як субарахноїдальний крововилив, внутрішньочерепна й екстракраніальна артеріальна дисекція та синдром оборотної мозкової вазоконстрикції – reversible cerebral vasoconstriction syndrome (RCVS). Ми призначили мультиспіральну комп’ютерну томографію (МСКТ) черепа й головного мозку з МСКТ-ангіографією, яка не виявила патологічних змін.
Периневральна катетеризація сідничного нерва при хронічних ішемічних больових синдромах нижньої кінцівки
Authors: Валенко О О , Лясковський Є М
Published: May 2019

Актуальність: хронічний больовий синдром при ішемічній акралгії є інтенсивним і виснажливим та ефективно не піддається медикаментозній корекції навіть при використанні мультимодальних схем.

Мета: досягти ефективного, тривалого, безпечного знеболення та покращення мікроциркуляції при хронічній ішемії стопи.

Матеріали та методи: ультразвукова навігація, поздовжнє розташування та оптимальне розміщення кінчика катетера, периневральне депо розчином гідроксіетилкрохмалю, підшкірне тунелювання.

Результати: ефективний контроль больового синдрому. Тривале функціонування катетера з використанням безпечних доз місцевого анестетику. Прискорення регенерації ран за рахунок покращення тканинної перфузії.

Висновки: оптимальне розміщення кінчика катетера під контролем ультразвуку зменшує дози місцевого анестетику. Передумовами для ефективного виконання маніпуляції є створення периневрального депо розчином гідроксіетилкрохмалю. Запобіганню дислокації сприяє катетеризація поздовжнім шляхом та надійна фіксація підшкірним тунелюванням.

Перспективи подальшого дослідження: безпечність більш тривалого використання катетера, доцільність ад’ювантів, доплерівський аналіз динаміки комплаєнсу та кровотоку тибіальних артерій.

Конфлікт інтересів. Відсутній.
Mieux comprendre l’empowermentdu consommateur
Authors: Fayn Marie-Georges , des Garets Véronique , Rivière Arnaud
Published: May 2019

Bien que le marketing se soit intéressé tardivement à l’empowerment, la profusion et la diversité des recherches, ainsi que l’absence d’une vision consensuelle, nécessitent un travail de clarification. Cet article propose ainsi de faire état des débats au sein de la littérature scientifique et de préciser les distinctions conceptuelles avec des notions connexes. Par ailleurs, considérant les évolutions récentes engendrées par le web participatif et le nouveau statut du consommateur-citoyen, ce travail propose, à partir d’une vision multidisciplinaire du concept originel, un enrichissement de l’approche de l’empowermenten marketing.
Center Rondon project and university extension
Authors: Peranzoni Vaneza Cauduro , Nascimento da Silva Alieze , Nascimento da Silva Carine , Possamai Menezes Luana , Nascimento da Silva Alieze
Published: May 2019

This work explores the experience of team participation the University of Cruz Alta Cruz Alta Rio Grande do Sul, Rondon Project. With goal to integrate the student to reality Brazil, and develop political, economic, and health care activities education for the poor, in January 2012, teachers and students visited the city of Aguiarnópolis, state of Tocantins in Brazil. The project is the intellectual effort of research and understanding of the process history, involving the saga of Brazilian Cândido Mariano Rondon and his legacy to the formation of anthropologists. This study proposes a reflection on Rondon Project while the university democratization of space public, considering it essential to approach institution with society. The Rondon Project is an extension activity that aims to consolidate the sense of social responsibility in university, knowledge on different Brazilian realities and production local collective projects.  It is intended, finally, contribute through this study to highlight the importance of alliance between scientific knowledge and empirical in everyone's life citizens, and the contribution of the Rondon Project to provide this exchange of knowledge between students and underserved communities.
National Reporting in the Framework of Human Rights Treaties
Authors: Karlas Jan
Published: May 2019

The key input into the monitoring of the implementation of universalhuman rights treaties is provided by national implementation reports. Inspite of the importance of these reports, there is a large variation in thequantities of these reports submitted by individual states. The existingresearch on this issue is considerably limited, especially in its empiricalscope. This text tests several explanatory hypotheses offered by thecontemporary literature on the participation of states in human rightstreaties and on the external transparency of states. The empirical analysiscarried out in the text involves the most recent data related to the coreuniversal treaties. This analysis reveals that the explanatory factor that is byfar the most statistically and substantively significant for the examinedtopic is the level of report submission for each region.
Evaluation of two Pseudomonas strains isolated from a maize rhizosphere as a plant growth promoting rhizobacteria
Authors: Chu Thanh Nguyen , Nguyen Nhi Yen , Dao Diep Ngoc , Tran Bao Thi Hoai , Hoang Minh Thi Thanh , Bui Le Van
Published: May 2019

Plant growth promoting rhizobacteria (PGPR) are free-living soil bacteria (rhizosphere bacteria), rhizoplane bacteria or endophytic bacteria that may promote plant growth and suppress plant diseases. The aim of this study is to evaluate effects of 2 rhizobacteria strains belonging to the genus Pseudomonas isolated from maize rhizosphere on the plant growth promotion. The in vitro tests showed that both of strain could fix nitrogen, solubilize phosphate, produced phytohormones (IAA and GAs), and improved the germination and growth of Arabidopsis thaliana. Under the greenhouse condition, growth parameters of bacteria inoculated maizes (fresh weight of shoot, dry weight of root, chlorophyll content) were also increased significantly than those of uninoculated ones. Our results reported 2 promising bacteria strain candidates and revealed their potential as a biological agent for eco-friendly agricultural practices.
Implementasi Strategi Membaca dan Menghafal Al Qur’an dan Pengaruhnya Terhadap Kemampuan Membaca dan Menulis Arab permulaan
Authors: Setiawan Akhmad Pandu
Published: May 2019

It was realized and became a consensus that education including Islamic education had a big contribution in realizing a superior civilization of the nation. But the fact states that the direction of Islamic education is still lagging behind and not to mention the dualism of the education system in Indonesia that is dictoomic (contradictory which tends to distance from one another) Based on the problem statement, this study aims to describe the Implementation Strategy of reading and memorizing the Qur'an and its influence on the ability to read and write Arabic beginning. This study follows an exploratory, descriptive and explanatory research design. The population is 23,960 children consisting of 279 Institutions (Al-Qur'an Education Park). The method of sampling in this study is that this study uses a simple random sampling system with the Slovin formula and from the members of the population taken as samples there are 100 respondents with the level of sig. p (0.01) In this study the authors used multiple linear regression analysis techniques. The results of this study concluded that there was a significant positive effect on the implementation of reading and memorizing strategies for the ability to read and write Arabic beginning
Studi al-Qur’an dan Hadits Mengenai Konsep Tarbiyah Iradah dalam Konsepsi Manajemen Sumber Daya Manusia (MSDM)
Authors: Ubaidillah Aan Eko Khusni
Published: May 2019

The lack of interest of the community in choosing Islamic education institutions is actually not because there has been a shift in Values ​​or religious ties that are starting to fade, but because most existing Islamic education institutions are less promising in the future and less responsive to current and future demands and demands. In fact, there are at least three things that are considered by the community in choosing educational institutions, namely Values ​​(religion), social status and ideals. The purpose of this article is to discuss the conception of Human Resource Management in students, especially related to Tarbiyatul Iradah. From the description that has been presented about the Study of the Qur'an and Hadith regarding the tarbiyah Iradah concept in the conception of Human Resource Management (HRM), it can be concluded as follows: 1) High quality human resources are resources that are able to create not only comparative value, but also innovative-generative competitive value using the highest energy such as intelligence, creativity, and imagination. 2) HR management that is effective and efficient towards our human beings, must go through four basic steps, namely; First, awareness that humans are servants of Allah SWT (Abdullah) and at the same time are His caliphs on earth; Secondly, as His caliph, every action must be based on the concept of being fair and not tyrannizing anyone; Third, synchronization between organizational goals and individual HR goals, namely Allah SWT, and; Fourth, the reference in human resource management is the character of the Prophet (Siddiq, Amanah, Fathanah, and Tabligh) 3) Tarbiyah as an effort in educating humans with the knowledge carried out by educators on the physical and spiritual development of students towards the formation of the main personality obedient to God, virtuous noble character, high knowledge and physical and spiritual health. Tarbiyah elements; a) Understanding and appreciation of Islam, b) Growth, Care and maintenance of faith, c) Growth of potential and talent so that it becomes a skill, d) The existence of stages (marhaliyah)
Shaping the Next Generation Pharmaceutical Supply Chain Control Tower with Autonomous Intelligence
Authors: Liotine Matthew
Published: May 2019

This paper summarizes the findings of an industry panel study evaluating how new Autonomous Intelligence technologies, such as artificial intelligence and machine learning, impact the system and operational architecture of supply chain control tower (CT) implementations that serve the pharmaceutical industry. Such technologies can shift CTs to a model in which real-time information gathering, analysis, and decision making are possible. This can be achieved by leveraging these technologies to better manage decision complexity and execute decisions at levels that cannot otherwise be managed easily by humans. Some of the key points identified are in the areas of the fundamental capabilities that need to be supported and the improved level of decision visibility that they provide. We also consider some the challenges in achieving this, which include data quality and integrity, collaboration and data sharing across supply chain tiers, cross-system interoperability, decision-validation and organizational impacts, among others.
Economía colaborativa y regulación: un análisis prospectivo
Authors: Ordóñez de Haro José Manuel , Torres José Luis
Published: May 2019

La denominada economía colaborativa ha experimentado un intenso proceso de expansión du­rante las últimas décadas, principalmente en lo que respecta a determinados servicios en el sector turístico y el transporte. Aunque este fenómeno no es nuevo, ya que históricamente ha tenido una gran importancia en las economías anteriores a la revolución industrial, su resurgimiento en los úl­timos años está asociado a factores tecnológicos y a la acumulación de capital doméstico en forma de bienes duraderos. El progreso tecnológico y el desarrollo de las tecnologías de la información y la comunicación (TIC) han posibilitado la eliminación de determinadas barreras de mercado y limitaciones de información, permitiendo a los hogares dedicar recursos de la producción domés­tica a la producción de bienes y servicios que son ofrecidos a otros consumidores. En este trabajo proponemos un marco teórico en el que estudiar el sector de la economía colaborativa, junto con el sector productivo de mercado y el sector de producción doméstica en el hogar. Estos tres secto­res presentan características diferenciadas en términos de los factores productivos que se utilizan en cada uno de ellos, definiéndose la economía colaborativa como un sector intermedio entre la producción tradicional de mercado y la producción doméstica. Sobre la base de esta propuesta, se identifican una serie de problemas que se plantean en la regulación de la economía colaborativa, así como algunas consideraciones respecto a los servicios turísticos y de transporte en este contexto.
¿Son los indultos en España proporcionales a la pena impuesta?
Authors: Abreu José , Jiménez Juan Luis
Published: May 2019

La figura del indulto, a pesar de su legalidad, genera controversia desde la perspectiva jurídi­ca y social. En este trabajo, y utilizando una muestra de los indultos concedidos en España entre diciembre de 1995 y enero de 2013, perseguimos ahondar en el análisis de este tópico a través del estudio de la proporcionalidad de los indultos, entendida como la relación entre la pena indulta­da y/o conmutada y el tamaño de la pena originalmente impuesta. Los resultados señalan que se indulta más porcentaje a quienes más pena fue impuesta. Esta falta de proporcionalidad de los indultos se ve incrementada porque sea un gobierno conservador el que conceda el indulto; que se realice en época de bonanza económica; o que el indulto haya sido solicitado por una Cofra­día, entre otros. El análisis confiere un mayor grado de subjetividad a esta controvertida figura.
Utilization of Management of Writing Scientific in the Learning Process in Higher Education
Authors: Moeins Anoesyirwan , Sudaryono Sudaryono , Khoirunisa Alfiah
Published: May 2019

In a scientific work, it is closely related to a writing management. Writing which is a writing activity is inseparable in the learning process. Writing can also be used as a management communication tool in conveying information. There are 4 (four) written communication elements as media tools. But recently a new paradigm has begun to develop that a management of scientific work does not have to be based on scientific research, but also a study of a problem that is analyzed professionally by experts. With the method of description using 5 (five) principles in the management of scientific writing to solve problems. So writing management is needed in compiling scientific papers in order to create good work by following the development of the industrial era 4.0. Thus, the task of intellectuals and intellectuals is not only able to read, but also must be able to manage writing about scientific writings and master the procedures for preparing scientific works. Utilization of Management of Writing Scientific Writing in the Learning Process in Higher Education.

Keywords: management of scientific work, management of writing, scientific work.