bluuebunny/crossref_metadata_2025 huggingface dataset:
Contagious symptoms: The need to tell stories and the health of the form
Authors: Dawes Durneen Lucy
Published: May 2022

Lucy Dawes Durneen introduces the first of two Special Issues of Short Fiction in Theory and Practice dedicated to the theme of ‘the health of the short story’. She considers the short story’s formal affinity with instability, fractured spaces and the fragility of existence, along with its ability to heal. She also comments on the way in which metaphors drawn from health are often deployed in relation to anxieties about the status and the survival of the short story form. She reflects on the literary context of writing and publishing during the COVID-19 pandemic and introduces the reader to the contents of the journal.
Investigation of proteomic profiles in canine lymphoma using tandem mass tag-based quantitative proteomics approach
Authors: Fonghem Piyanoot , Pisitkun Trairak , Rattanapinyopituk Kasem , Sirivisoot Sirintra , Rungsipipat Anudep
Published: May 2022

Background and Aim: Specific tumor biomarkers are useful for the early diagnosis of cancer or can predict the recurrence of neoplastic disease in humans and animals. Lymphoma in dogs could be classified into B-, T-, and NK-cell origins. T-cell lymphoma has the worst prognosis with a shorter survival time and disease-free interval. This study aimed to identify the differential serum protein expressions of canine B- and T-cell lymphomas compared with healthy dogs using a tandem mass tag (TMT)-based quantitative proteomics.

Materials and Methods: Serum samples were collected from 20 untreated canine lymphomas (14 B-cells and 6 T-cells) and four healthy control dogs. Sera peptides from each sample were processed for TMT 10-plex tagging and analyzed using liquid chromatography-mass spectrometry (MS). Differential proteome profiling was then compared between lymphoma and control.

Results: We discovered 20 elevated and 14 decreased serum proteins in the lymphoma group relative to the healthy group. Six candidate increased proteins in canine lymphomas were beta-actin cytoplasmic 1 (ACTB, p=0.04), haptoglobin (p=0.002), beta-2 microglobulin (β2M, p=0.007), beta-2 glycoprotein 1 (APOH, p=0.03), metalloproteinase inhibitor 1 (TIMP-1, p=0.03), and CD44 antigen (p=0.02). When compared between B- and T-cell lymphomas, B-cell phenotypes had upregulated immunoglobulin (Ig) heavy chain V region GOM (p=0.02), clusterin (p=0.01), apolipoprotein C1 (APOC1, p=0.05), and plasminogen (p=0.02).

Conclusion: These findings were investigated quantitative serum proteomes between B- and T-cell lymphomas using TMT-based MS. ACTB, β2M, APOH, TIMP-1, CD44 antigen, Ig heavy chain V region GOM, and APOC1 are novel candidate proteins and might serve as a lymphoma biomarker in dogs. However, evaluation with an increased sample size is needed to confirm their diagnostic and prognostic ability.
A simultaneous pancreas-kidney transplantation for type 1 diabetes mellitus after a long-term of receiving hemodialysis renal replacement therapy. Clinical сase
Authors: Salimkhanov R. Kh. , Yevloyeva M. I. , Severina A. S. , Shamkhalova M. Sh. , Trubitsyna N. P. , Moysyuk Y. G.
Published: May 2022

At the present time, a simultaneous pancreas-kidney transplantation (SPKT) is an effective method of treatment for patients on renal replacement therapy by hemodialysis program in the outcome of the terminal stage of diabetic nephropathy. This method of treatment solves several problems: it reduces the severity of intoxication syndrome, contributes to the achievement of euglycemia in most cases, which certainly allows to slow the progression of micro- and macrovascular complications of diabetes. Despite of positive effect of euglycaemia and kidney function normalization, the accumulated metabolic memory legacy of long-term uncompensated diabetes mellitus is realized, which makes a posttransplantational rehabilitation of patients difficult. A duration of hemodialysis therapy is known as a cardiovascular events risk factor, which affects the surgery result and favorable posttransplant period. More often after successful SPKT microvascular diabetic complications are stabilized, but macrovascular diabetic complications, diabetic neuroosteoarthropathy and mineral and bone disease are progressed. That’s why is necessary to perform regular examination after SPKT by a team of specialists, including nephrologist, endocrinologist, cardiologist, ophthalmologist with correction of ongoing therapy. Therefore both the preparation of  the patient for transplantation with the earliest possible placement on the waiting list and the post-transplant rehabilitation afterwards are extremely important.
Editorial : Voices from Around the Globe
Authors: Schreiber Birgit , Luescher Thierry M , Moja Teboho
Published: May 2022

JSAA has been seeking to provide an opportunity for Student Affairs professionals and higher education scholars from around the globe to share their research and experiences of student services and student affairs programmes from their respective regional andinstitutional contexts. This has been given a specific platform with the guest-edited issue “Voices from Around the Globe” which is the result of a collaboration with the International Association of Student Affairs and Services (IASAS), and particularly with the guest editors, Kathleen Callahan and Chinedu Mba.In this respect, we are pleased that the present issue highlights the intersection of global and local issues in Student Affairs, and of debates around local professionalisation and epistemic-discursive communities of practice in Student Affairs. Global and local issues are not so much about the spatial but the framework and lens of Student Affairs, which simultaneously aim to be locally relevant and embedded, and globally referenced to an overarching set of guidelines abstracted from the local and articulated at the global. Correspondingly it is instructive to invoke the notion of the Global Gemeinschaft(Robertson, 1995) as one community in the world, with many communities inherent within it; the notion that new identity is shaped by global-international and global-local influences on the epistemic-discursive community of Student Affairs (Castell, 1997). Furthermore, the JSAA-IASAS collaborative issue also brings into focus global trends and their local expression, including the reorganisation of knowledge in Student Affairs in relation to changing local realities. By foregrounding Botswana, China, South Africa and the USA, a comparative discourse is set up which is part of the global
Interpersonal Conflicts and Styles of Managing Conflicts among Students at Bahir Dar University, Ethiopia
Authors: Bazezew Arega , Neka Mulugeta
Published: May 2022

Interpersonal conflict happens everywhere and at any time and is inherent in all societies. However, the methods of managing such conflict are quite different from one organisation to the other. The general objective of the study was to assess interpersonal conflicts and styles of managing conflictsamong students at Bahir Dar University. Mixed-methods research composed of quantitative and qualitative approaches was implemented for the study. One-way Multivariate Analysis of Variance was employed to identify the interaction effect between dependent and independent variables. The study showed that the major sources of conflicts were ethnic differences, religious diversity, sexual abuse, theft and insulting. It was also noted that compromising, avoiding and collaborating were frequently used conflict management styles between students. It is recommended that university leaders and students be expected to understand the real causes of conflicts for healthier management styles.
Employee Satisfaction and its Impact on Faculty Members' Performance at Al Ain University of Science and Technology in the UAE
Authors: Al-Kassem Dr. Amer Hani , Marwaha Sunita
Published: May 2022

This study aims to determine the level of job satisfaction and examine factors affecting job satisfaction among Faculty members at Al Ain University of Science and Technology in the United Arab Emirates. A sample of 110 faculty members, responded to the study. Job satisfaction was measured by The Brayfield Rothe Job Satisfaction Index as modified by Warner and self-efficacy by the General Self-efficacy Scale. T-test analysis, Pearson correlation, one-way analysis of variance with Tukey post hoc and multiple regression analyses were employed. Results indicated that faculty members had a high level of job satisfaction. Moreover, results showed differences in the level of job satisfaction for men with higher academic ranks and more teaching experience. No significant difference in job satisfaction could be seen among married and bachelor faculty members. Therefore, this variable was excluded from the further analysis. The result of stepwise multiple linear regression showed that the independent variables (self-efficacy, gender, age, teaching experience, and academic rank) accounted for 46.7% of the variance in the job satisfaction of faculty members. Findings showed that higher self-efficacy aligned with high levels of job satisfaction hence self-efficacy emerged as the most significant predictor of job satisfaction. Recommendations include that higher education policymakers in the United Arab Emirates must focus attention on self-efficacy and its inclusion in recruitment review and training & development of faculty, as an effort to improve faculty members’ job satisfaction.
In vitro propagation and somaclonal variation study of Phlogacanthus thyrsiformis Nees an ethnic medicinal plant
Authors: Baro Tikendrajit , Das Sandeep
Published: May 2022

Bodoland Territorial Region is very rich in natural bioresources, and the Bodo tribes of the region use numerous ethnic medicinal plants to treat different kinds of diseases. Phlogacanthus thyrsiformis Nees is an important medicinal shrub species used in the region to treat different kinds of diseases. The objectives of the present study were to develop an efficient in vitro mass propagation technique of the species using nodal explant and study genetic stability in the genome of in vitro propagated plantlets by different RAPD markers. Effective explant surface sterilisation resulted at 2 minutes of treatment with 0.1% mercuric chloride. Explant responses were found most effective in the full strength MS + 1mg/l BAP (6- benzyl amino purine), and explant highest shoot proliferation multiplication and rooting were found in the media MS + 1 mg/l BAP + 0.250 mg/l NAA. Ex vitro rooting of micro propagated plants was most effective when the explants were dipped in 1mg/l IBA for an hour. RAPD assays were conducted using eight sets of random primers (OPC02, OPC05, OPC07, OPC08, OPC09, OPX06, DK2 and OPA01). All the primers except OPC07 and OPA01 formed monomorphic DNA bands in gel electrophoresis and polymorphism was detected by OPC07 and OPA01 primer.
Diagnosis and Clinical Features in Autoimmune-Mediated Movement Disorders
Authors: Hsieh Pei-Chen , Wu Yih-Ru
Published: May 2022

Movement disorders are common manifestations in autoimmune-mediated encephalitis. This group of diseases is suspected to be triggered by infection or neoplasm. Certain phenotypes correlate with specific autoantibody-related neurological disorders, such as orofacial-lingual dyskinesia with N-methyl-D-aspartate receptor encephalitis and faciobrachial dystonic seizures with leucine-rich glioma-inactivated protein 1 encephalitis. Early diagnosis and treatment, especially for autoantibodies targeting neuronal surface antigens, can improve prognosis. In contrast, the presence of autoantibodies against intracellular neuronal agents warrants screening for underlying malignancy. However, early clinical diagnosis is challenging because these diseases can be misdiagnosed. In this article, we review the distinctive clinical phenotypes, magnetic resonance imaging findings, and current treatment options for autoimmune-mediated encephalitis.
Non‐invasive MR imaging techniques for measuring femoral arterial flow in a pediatric and adolescent cohort
Authors: Caterini Jessica E. , Rendall Kate , Cifra Barbara , Schneiderman Jane E. , Ratjen Felix , Seed Mike , Rayner Tammy , Weiss Ruth , McCrindle Brian W. , Noseworthy Michael D. , Williams Craig A. , Barker Alan R. , Wells Gregory D.
Published: May 2022

Magnetic Resonance Imaging (MRI) is well‐suited for imaging peripheral blood flow due to its non‐invasive nature and excellent spatial resolution. Although MRI is routinely used in adults to assess physiological changes in chronic diseases, there are currently no MRI‐based data quantifying arterial flow in pediatric or adolescent populations during exercise. Therefore the current research sought to document femoral arterial blood flow at rest and following exercise in a pediatric‐adolescent population using phase contrast MRI, and to present test‐retest reliability data for this method. Ten healthy children and adolescents (4 male; mean age 14.8 ± 2.4 years) completed bloodwork and resting and exercise MRI. Baseline images consisted of PC‐MRI of the femoral artery at rest and following a 5 × 30 s of in‐magnet exercise. To evaluate test‐retest reliability, five participants returned for repeat testing. All participants successfully completed exercise testing in the MRI. Baseline flow demonstrated excellent reliability (ICC = 0.93, p = 0.006), and peak exercise and delta rest‐peak flow demonstrated good reliability (peak exercise ICC = 0.89, p = 0.002, delta rest‐peak ICC = 0.87, p = 0.003) between‐visits. All three flow measurements demonstrated excellent reliability when assessed with coefficients of variance (CV’s) (rest: CV = 6.2%; peak exercise: CV = 7.3%; delta rest‐peak: CV = 7.1%). The mean bias was small for femoral arterial flow. There was no significant mean bias between femoral artery flow visits 1 and 2 at peak exercise. There were no correlations between age or height and any of the flow measurements. There were no significant differences between male and female participants for any of the flow measurements. The current study determined that peripheral arterial blood flow in children and adolescents can be evaluated using non‐invasive phase contrast MRI. The MRI‐based techniques that were used in the current study for measuring arterial flow in pediatric and adolescent patients demonstrated acceptable test‐retest reliability both at rest and immediately post‐exercise.
Supercomplex supercomplexes: Raison d’etre and functional significance of supramolecular organization in oxidative phosphorylation
Authors: Nath Sunil
Published: May 2022

Following structural determination by recent advances in electron cryomicroscopy, it is now well established that the respiratory Complexes I–IV in oxidative phosphorylation (OXPHOS) are organized into supercomplexes in the respirasome. Nonetheless, the reason for the existence of the OXPHOS supercomplexes and their functional role remains an enigma. Several hypotheses have been proposed for the existence of these supercomplex supercomplexes. A commonly-held view asserts that they enhance catalysis by substrate channeling. However, this – and other views – has been challenged based on structural and biophysical information. Hence, new ideas, concepts, and frameworks are needed. Here, a new model of energy transfer in OXPHOS is developed on the basis of biochemical data on the pure competitive inhibition of anionic substrates like succinate by the classical anionic uncouplers of OXPHOS (2,4-dinitrophenol, carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone, and dicoumarol), and pharmacological data on the unique site-selective, energy-linked inhibition of energy conservation pathways in mitochondria induced by the guanidine derivatives. It is further found that uncouplers themselves are site-specific and exhibit differential selectivity and efficacy in reversing the inhibition caused by the Site 1/Complex I or Site 2/Complexes II–III-selective guanidine derivatives. These results lead to new vistas and sufficient complexity in the network of energy conservation pathways in the mitochondrial respiratory chain that necessitate discrete points of interaction with two classes of guanidine derivatives and uncoupling agents and thereby separate and distinct energy transfer pathways between Site 1 and Site 2 and the intermediate that energizes adenosine triphosphate (ATP) synthesis by Complex V. Interpretation based on Mitchell’s single-ion chemiosmotic theory that postulates only a single energy pool is inadequate to rationalize the data and account for the required complexity. The above results and available information are shown to be explained by Nath’s two-ion theory of energy coupling and ATP synthesis, involving coupled movement of succinate anions and protons, along with the requirement postulated by the theory for maintenance of homeostasis and ion translocation across the energy-transducing membrane of both succinate monoanions and succinate dianions by Complexes I–V in the OXPHOS supercomplexes. The new model of energy transfer in mitochondria is mapped onto the solved structures of the supercomplexes and integrated into a consistent model with the three-dimensional electron microscope computer tomography visualization of the internal structure of the cristae membranes in mammalian mitochondria. The model also offers valuable insights into diseased states induced in type 2 diabetes and especially in Alzheimer’s and other neurodegenerative diseases that involve mitochondrial dysfunction.
Developing a skills-based practical chemistry programme: an integrated, spiral curriculum approach
Authors: Campbell Craig D. , Midson Megan O. , Bergstrom Mann Patrick E. , Cahill Samuel T. , Green Nicholas J. B. , Harris Matthew T. , Hibble Simon J. , O’Sullivan Saskia K. E. , To Trang , Rowlands Lucy J. , Smallwood Zoe M. , Vallance Claire , Worrall Andrew F. , Stewart Malcolm I.
Published: May 2022

Teaching practical laboratory skills is a key component of preparing undergraduate students for future careers in chemistry and elsewhere. In this paper, we present our new strategy to teach practical skills to undergraduate chemistry students. We report a Skills Inventory, a list of the suggested practical skills a graduate chemist should possess; this list was compiled by chemists across the UK. In our new practical course we begin by decoupling the practical skill from the theoretical background, compelling students to first master the basic processes needed to carry out a specific technique. In what we have termed a ‘spiral curriculum’ approach, skills are revisited on multiple occasions, with increasing complexity and greater emphasis on underlying theory. The new course makes links across traditional subdisciplines of chemistry to avoid compartmentalisation of ideas.
Machine learning doped MgB2 superconductor critical temperature from topological indices
Authors: Zhang Yun , Xu Xiaojie
Published: May 2022

Due to the absence of weak-links in grain boundaries, less anisotropy, and high availabilities at reasonable cost, magnesium boride, MgB2, has been studied extensively in the past decade. It has relatively high critical temperature, which is correlated to crystallographic and electronic structures. Two topological indices, the electric connectivity index and valence energy level connectivity, are characteristics of compound branching. We develop the Gaussian process regression (GPR) model to shed light on the relationship between topological descriptors and superconducting transition temperature for doped MgB2 superconductors. The model is highly accurate and stable, which contributes to fast predictions of superconducting transition temperature.
The study of the particle size effect on the physical properties of TiO2/cellulose acetate composite films
Authors: Ali Hajer A. , Hameed Nahida J.
Published: May 2022

The cast method was used to synthesize cellulose acetate (CA)/titanium oxide (TiO2) composites by varying TiO2 particle sizes at different weight ratios of 1, 1.5, 2, 2.5, and 3 wt%. The relationship between structural diversity and performance was explored. Microstructures and chemical composition of as-prepared composite films were revealed using field-emission scanning electron microscopy and Fourier-transform infrared spectroscopy. The tensile strength increased from 46.8 MPa for pure CA to 54.7 MPa for the CA-1% micro-TiO2 composite and 81.7 MPa for the CA-2% nano-TiO2 composite, according to the mechanical properties. The tensile strength decreased due to some degrees of agglomeration of filler particles above a critical content. UV-vis transmittance spectra showed that pure CA was almost transparent, CA-micro-TiO2 films were less transparent than pure CA, and CA-nano-TiO2 films could efficiently block the light. XRD diffraction for the synthesized membranes was performed. The patterns of micro-TiO2 and nano-TiO2 were shown as 2θ = 25° for the anatase phase and 2θ = 18.5 for the pure CA film, respectively. The hydrophilicity of films was also measured using the sessile drop technique. The contact angle value for the pure CA was 61.3°. As the amount of TiO2 added to the films increased, the contact angles of the CA-micro TiO2 and CA-nano TiO2 films reduced from 53.2° to 29° and from 51.5° to 27°, respectively. The produced films’ improved wettability indicated that these films could be employed as filters.
A 2-bp deletion mutation in SMPD1 gene leading to lysosomal acid sphingomyelinase deficiency in a Chinese consanguineous pedigree
Authors: Kang Han , Zhou Min , Xie Chengxiu , Lu Kangmo
Published: May 2022

Objectives

Niemann–Pick disease type A (NPDA, MIM: 257200) is an autosomal recessive sphingolipidosis caused by lysosomal acid sphingomyelinase (ASM) deficiency. A cluster of genes located at chromosome 11p15 have been reported to be imprinted genes, such as TSSC5, TSSC3, and ZNF215 that flanking SMPD1 gene. It was reported by a few recent studies that SMPD1 gene was paternally imprinted and maternally preferentially expressed.

Case presentation

A five-month-old boy with severe anemia, hepatosplenomegly and bone marrow foam cells was recruited from a complete cousin couple. To determine whether boy suffered from NPDA, ASM activity and SMPD1 gene sequencing were performed on available individuals of this pedigree including the proband, his parents and sister. The ASM activities of proband and parents showed deficiency (17.7 nmol/h/g-protein) and about 50% decreased (83.3 nmol/h/g-protein), respectively, compared with normal controls (204.5 nmol/h/g-protein). SMPD1 gene sequencing in the proband revealed a homozygous mutation c.1420_1421del, which leads to an open reading frameshift and a premature stop codon. The parents and some individuals of this family demonstrated heterozygous mutation at this locus. To investigate whether SMPD1 gene is imprinted as reported previously, the expression of RNA level was studied in the whole family members available. The members with heterozygous mutation for c.1420_1421del showed that both paternal and maternal inherited alleles were expressed.

Conclusions

This study reported a c.1420_1421del mutation in SMPD1 gene which caused ASM activity decrease and this locus was biallelically expressed in heterozygous subjects implicating SMPD1 is not imprinted in this family.
Steady state thermal hydraulic modelling of WWR-S tank-in-pool research reactor for the purpose of its power upgrading
Authors: Ibrahim Said M.A. , Esawy Mohamed H. , Yousif Hossam I.
Published: May 2022

This paper presents a newly developed steady state core thermal hydraulic model (named SSTH-RR10 model) for upgrading the Egyptian first Research Reactor (ETRR-1), from its original power of 2 MWth to a higher level of 10 MWth, by considering different types of nuclear fuels. The SSTH-RR10 model is capable to predict and calculate, by means of a developed computer program, all the steady state thermal hydraulic parameters for the defined core configuration for each fuel type at 10 MWth. Three different fuel types were investigated: the reference fuel EK-10 rod type, the MTR plate type, and the IRT-4M ducted type. For each fuel type, the distribution of central fuel, clad, and coolant temperatures for average and hot channels of the core were predicted in the axial direction. Power distributions and pressure gradients were predicted as well. Moreover, the program calculates the safety limits and margins against the critical phenomena encountered such as the Onset of Nucleate Boiling (ONB), Departure from Nucleate Boiling (DNB), and the Onset of Flow Instability (OFI). Results of the SSTH-RR10 program for benchmarks of powers of 2 and 10 MWth are verified by comparing it with the published results of the International Atomic Energy Agency (IAEA), and those published for other programs such as PARET code, and very good agreement is found. The safety margins against ONB and DNB were evaluated in which the minimum DNB ratio was found to be about 3.1, which gives a sufficient margin against the DNB. The present work gives confidence in the model results and applications.
The latest cutoff value of high-sensitivity cardiac troponin I (access hs-TnI) for major adverse cardiac events during the perioperative period of coronary artery bypass grafting: a retrospective study from a single heart center
Authors: Li Shan-shan , Nan Wen-hui , Yin Yue , Qin Li , Jia Mei , Yue Zhi-hong
Published: May 2022

Objectives

To investigate the latest cutoff value of high-sensitivity cardiac troponin I for major adverse cardiac events (MACEs) during the perioperative period of coronary artery bypass grafting (CABG).

Methods

A total of 200 patients, into MACEs and non-MACEs groups according to the occurrence of MACEs over a 12 day postoperative period underwent a complete baseline history survey, physical examination, 12-lead electrocardiogram (ECG), and laboratory examination during a preoperative cardiology consultation. Serum levels of hs-TnI, myohemoglobin, creatine kinase MB isoform (CK-MB), and B-type natriuretic peptide were assessed using a Beckman DXI800 automatic chemiluminescence immune analyzer.

Results

The 200 patients were classified into the MACEs (n=10) and non-MACEs (n=190) groups. Based on a receiver-operating characteristic analysis, the optimal 4–6 h postoperative hs-TnI, CK-MB, and MYO joint cut-off levels for predicting perioperative MACEs were 2,622.3 pg/mL, 17.9 ng/mL, and 190.2 ng/mL, respectively. The AUC was 0.779 (95% confidence interval: 0.622–0.937; p<0.05) with a sensitivity of 80.0% and a specificity of 74.0%. When the hs-TnI, CK-MB, and MYO levels exceeded the joint cut-off levels, the incidence of MACEs was significantly increased during the perioperative period (Log rank p<0.05). Cox regression analysis showed that dyslipidemia, left ventricular ejection fraction <50%, hs-TnI level, and myohemoglobin level were the main risk factors for MACEs after CABG (p<0.05).

Conclusion

An hs-TnI level of 2,622.3 pg/mL, CK-MB level of 17.9 ng/mL, and MYO level of 190.2 ng/mL were the cutoff values for predicting MACEs. Dyslipidemia, left ventricular ejection fraction <50%, hs-TnI level, and myohemoglobin level were the main risk factors for MACEs after CABG.
Linezolid for resistant Gram-positive bacterial infections in children under 12 years: A meta-analysis
Authors: Wu Qian , Xu Xiaohua , Tian Mingqing , Jiang Jianyang
Published: May 2022

Both linezolid and vancomycin have good efficacy in the treatment of resistant Gram-positive bacterial infections. This systematic review and meta-analysis aimed to compare the efficacy and safety of linezolid vs vancomycin for the treatment of resistant Gram-positive bacterial infections in children under 12 years.

Five randomly controlled trials involving 638 children that were treated with linezolid and vancomycin for resistant Gram-positive bacterial infections were searched from medical databases. Meta-analysis showed that linezolid and vancomycin had equivalent efficacies in clinical cure rates in the intent-to-treat population (95% confidence interval [CI] 0.88, 2.09) and microbiologically evaluable patients (95% CI: 0.46, 2.47). Linezolid and vancomycin also had equivalent pathogen eradication rates for Staphylococcus aureus (95% CI: 0.31, 4.81), methicillin-resistant S. aureus (95% CI: 0.36, 5.34), Enterococcus faecalis (95% CI: 0.32, 8.76), and coagulase-negative Staphylococci (95% CI: 0.43, 4.01). Vancomycin resulted in a higher incidence of alanine aminotransferase increase (95% CI: 0.37, 0.97), red man syndrome (95% CI: 0.01, 0.28), and rash (95% CI: 0.11, 0.73) than linezolid. Clinically, linezolid had a superior safety to vancomycin for resistant Gram-positive infections.

Linezolid might be prescribed for the treatment of resistant Gram-positive bacterial infections in children under 12 years.
Process-Panentheism and the “Only Way” Argument
Authors: Langby Lina
Published: May 2022

Given panentheism, when trying to offer a plausible solution to the problem of evil, what is the most promising way forward? In this article, I argue that a panentheist who wants to answer the problem of evil by using the “only way” argument should embrace the metaphysics of process theism. In other words, she ought to be a process-panentheist. Process theism is a version of panentheism, while panentheism generally need not to imply process theism. I shall use the terms “process-panentheist” and “non-process-panentheist” to differentiate adherents of these two forms of panentheism. I examine the “only way” argument as a possible theodicy for panentheists and conclude that it is only a convincing theodicy for the panentheist if (i) she is a process-panentheist, or (ii) she thinks this is the best possible world. If she is a non-process-panentheist or does not think this is the best possible world, the “only way” approach fails to be a coherent theodicy.
A rhetoric of inauthenticity: critical object images in Woolf’s Victorian scenes
Authors: Sönmez Margaret J.-M.
Published: May 2022

This paper extends the fields of visual and object semiosis, style, and rhetoric by introducing the concept of critical object images. It identifies five of their rhetorical functions in literature and demonstrates the semiotic and rhetorical specificity and force of literary object images. Inter-disciplinary concepts and theories used in the study are introduced before the concept is tested and developed through analyses of object images with critical roles in the Victorian scenes of Virginia Woolf’s novels. The inductive analyses trace the semiosis and stylistic affordances (meanings) of the selected critical object images, with reference to three categories of kitsch inauthenticity, and their formal and cultural contexts, noting the rhetorical function(s) they serve. Multimodal stylistics and the semiotics of visual images and of objects are used in these analyses, and the unique contribution of critical object images as rhetorical elements in literature is uncovered and explained. The analysis of Woolf’s representation of selected objects shows how the critical object images function rhetorically, through their stylistic connotations (here of kitsch inauthenticity), to present unambiguous meanings that are not openly stated in the texts’ verbal discourse.
Influence of leading edge point on aerodynamic performance of asymmetric leading edge compressor airfoils
Authors: Yang Guanhua , Gao Limin , Wang Haohao , Chang Longrui
Published: May 2022

Leading edge (LE) plays a prominent role in compressor flow. The asymmetric leading edge (ASYLE) has shown superiorities to symmetric LE in blade aerodynamic performance. However, the influencing rules of ASYLE design parameters are still ambiguous. In this work, numerical calculations were conducted to investigate the influencing effects of LE point curvature and position. The results show that the operating range of ASYLE blades expand with the decrease of LE point curvature, which helps to moderate LE flow acceleration, while the LE point position mainly affects the operating range. It is also revealed that the SSLE curvature peak is supposed to be close to LE point, and the maximum value of PSLE curvature should be restricted.
Lower and Middle Palaeolithic evidence from the North Aegean coastline of Çanakkale, Turkey
Authors: Bulut Hande , Taşkıran Harun , Özçelik Kadriye , Karahan Göknur
Published: May 2022

TheÇanakkale-Balıkesir Coastline Palaeolithic Survey Projectcovers the Çanakkale and Balıkesir coastlines of the Aegean. It aims to reveal Palaeolithic assemblages and their connection to the surrounding islands—primarily Lesbos. In 2021, four important findspots were detected on the Çanakkale coastline, and more than 500 lithics were uncovered, exhibiting the characteristics of large cutting tools, as well as pebble and prepared core technologies. These tools attest to the presence of hominins along the Çanakkale coastline during the Lower Palaeolithic.
Perceived Motor Synchrony With the Beat is More Strongly Related to Groove Than Measured Synchrony
Authors: Matthews Tomas E. , Witek Maria A. G. , Thibodeau Joseph L. N. , Vuust Peter , Penhune Virginia B.
Published: May 2022

The sensation of groove can be defined as the pleasurable urge to move to rhythmic music. When moving to the beat of a rhythm, both how well movements are synchronized to the beat, and the perceived difficulty in doing so, are associated with groove. Interestingly, when tapping to a rhythm, participants tend to overestimate their synchrony, suggesting a potential discrepancy between perceived and measured synchrony, which may impact their relative relation with groove. However, these relations, and the influence of syncopation and musicianship on these relations, have yet to be tested. Therefore, we asked participants to listen to 50 drum patterns with varying rhythmic complexity and rate their sensation of groove. They then tapped to the beat of the same drum patterns and rated how well they thought their taps synchronized with the beat. Perceived synchrony showed a stronger relation with groove ratings than measured synchrony and syncopation, and this effect was strongest for medium complexity rhythms. We interpret these results in the context of meter-based temporal predictions. We propose that the certainty of these predictions determine the weight and number of movements that are perceived as synchronous and thus reflect rewarding prediction confirmations.
Investigating the Shared Meaning of Metaphorical Sound Attributes
Authors: Rosi Victor , Houix Olivier , Misdariis Nicolas , Susini Patrick
Published: May 2022

Music or sound professionals use specific terminology to communicate about timbre. Some key terms do not come from the sound domain and do not have a clear definition due to their metaphorical nature. This work aims to reveal shared meanings of four well-used timbre attributes: bright, warm, round, and rough. We conducted two complementary studies with French sound and music experts (e.g., composers, sound engineers, sound designers, musicians, etc.). First, we led interviews to gather definitions and instrumental sound examples for the four attributes (N = 32). Second, using an online survey, we tested the relevance and consensus on multiple descriptions most frequently evoked during the interviews (N = 51). The analysis of the rich corpus of verbalizations from the interviews yielded the main description strategies used by the experts, namely acoustic, metaphorical, and source-related. We also derived definitions for the attributes based on significantly relevant and consensual descriptions according to the survey results. Importantly, the definitions rely heavily on metaphorical descriptions. In sum, this study presents an overview of the shared meaning and perception of four metaphorical timbre attributes in the French language.
The Influence of Eggshell Powder as Additive on the Physical and Mechanical Properties of Stone Mastic Asphalt
Authors: Hong Chee Goh , P.J. Ramadhansyah
Published: May 2022

Stone mastic asphalt (SMA) has been widely used in Europe since the early 1960s, followed by numberous trials in countries such as the USA and Australia, where it has been positioned as a premium pavement surfacing course purposely for heavy duty pavements, highways and other roads with heavy truck traffic. In addition, Malaysia's demand for 900 million eggs per month produces a significant amount of solid waste. If all these eggshells were recycled and used for fertiliser or other purposes, this would help to reduce the overall amount of solid waste to a certain level. The eggshell in the solid food waste has been studied in detail and found to be suitable for processing into eggshell powder (EP) additives and applied to today's construction industry. Thus, this research learnt the influence of EP as bitumen modification in stone mastic asphalt (SMA) in term of physical and mechanical properties. Moreover, this research also determines the optimum percentage of EP as the bitumen modifier by the combination of 0%, 4%, 8% and 12%. The physical properties of SMA can determine through cantabro loss, permeability and marshall stability test, while the mechanical properties of SMA can determine through indirect tensile strength. In short, 12% of ESP was the optimum percentage as bitumen modifier in SMA, it increased the strength in the mechanical properties from 201 kPa to 230 kPa.
The Influence of Drop Panel's Dimensions on the Punching Shear Resistance in Ultra-High-Performance Fiber-Reinforced Concrete Flat Slabs
Authors: Muhammed Twana Ali , Rahim Karim Dr. Ferhad
Published: May 2022

Ultra-high performance fiber reinforced concrete (UHPFRC) is a high-performance cementitious material with enhanced tension, compression, and toughness, strengths in the post crack region with high ductility, toughness, and durability. The companies prefer to use it to construct highly durable structures such as high-rise buildings, towers, and bridges. In addition, the thickness of the flat slab produced by UHPFRC might be thinner than the conventional concrete. One problem that has always been a concern in a flat slab is the punching shear failure since this failure is brittle and occurs suddenly without any previous notice. Besides, the position of the critical section for punching shear could be changed based on the thickness of the drop panel and the inclusion of fiber in the concrete. This paper highlights the effect of drop panels dimension on the punching shear resistance in UHPFRC flat slabs. The four two-way interior UHPFRC supported flat slab panels, consisting of one control flat slab without drop panels and three-flat slabs with different sizes of drop panels (10.5%,14.5%, and 19%) of the total area of slab drop panels, tested under punching load. Results indicated that the covered area of flat slabs by drop panel around 10.5% improved punching load up to %20 and 37% at the crack and ultimate loads. Furthermore, the test results show that the efficient covered area for resisting punching was 10.5% of the total area of the tested slab. Besides, the deflection values, strain in reinforcement and concrete, rotation at supports, and the inclination angles of cracks were improved due to the stiffness enhancement in the flat slabs.
Hyperlactatemia as a Risk Stratification for Postinfarction Ventricular Septal Rupture
Authors: Kinoshita Takeshi , Asai Tohru , Suzuki Tomoaki
Published: May 2022

Background: Surgical repair for postinfarction ventricular septal rupture (VSR) is a challenging operation, especially in the acute phase with unstable hemodynamics. We retrospectively examined the value of measuring lactate, which can be a quantitative indicator of end-organ ischemia caused by multiple factors including ineffective cardiac output, for risk stratification in patients undergoing surgical repair.
Methods: From April 2008 to December 2018, 33 consecutive patients were admitted to our hospital with a diagnosis of VSR and underwent VSR repair surgery within 24 hours of admission. We categorized patients into 3 groups based on the distribution of preoperative blood lactate level: <5 mmol/L (n = 16), 5 to 10 mmol/L (n = 11), and >10 mmol/L (n = 6).
Results: There was no intraoperative death, but the prognosis for patients with lactate >10 mmol/L was extremely poor, with a median postoperative survival time of only 23 days [25th percentile 6, 75th percentile 30]. Five of 6 patients (83%) died within 30 days after surgery. The risk-adjusted hazard ratio (95% confidence interval) for mortality per 1 SD (0.41-unit) increase in log-transformed preoperative lactate level (equivalent to a 4.10-fold increase) was 2.85 (1.57 to 5.19). Patients with lactate 5 to 10 mmol/L had 3.95-fold and those with lactate >10 mmol/L had 6.03-fold higher risk of mortality than those with lactate <5 mmol/L.
Conclusion: Elevation of preoperative serum lactate is significantly associated with mortality in patients who underwent VSR repair. The findings of this study highlight the value of measuring lactate level for risk stratification.
CONTROL STRATEGIES TO ELIMINATE HARMONICS IN POWER GENERATION SYSTEMS BASED ON A DOUBLY-FED INDUCTION GENERATOR
Authors:   Institute of Electrodynamics of the National Academy of Sciences of Ukraine,  pr. Peremohy, 56, Kyiv, 03057, Ukraine, Kondratenko I.P. , Karlov A.N. ,   Institute of Electrodynamics of the National Academy of Sciences of Ukraine,  pr. Peremohy, 56, Kyiv, 03057, Ukraine, Kryshchuk R.S. ,   Institute of Electrodynamics of the National Academy of Sciences of Ukraine,  pr. Peremohy, 56, Kyiv, 03057, Ukraine
Published: May 2022

The action of high-density pulsed currents (109 A/m2) leads to the appearance of the electro-plastic effect in metal products. It is proposed to use magnetic pulse treatment of nonmagnetic plates by electromagnetic inductors with a U-shaped magnetic circuit for local flow pulsed currents in the nonmagnetic plates. The work aims to establish an influence of a ferromagnetic platform with nonlinear magnetic permeability on pulsed eddy currents and magnetic pressure of nonmagnetic metal plates with different electrical conductivity in modeling magnetic pulse treatment of welded joints to achieve the electro-plastic effect. Numerical simulation of pulsed electromagnetic fields by the finite element method is used. The current calculation in the inductor's winding is performed by solving the equations of the magnetic field and the electric circuit equations for a discrete-time interval. A power source is a capacitor that is charged to a specific voltage. To study the effect of the ferromagnetic platform on eddy currents and forces in a nonmagnetic plate with its different electrical conductivity, the same pulsed current in the inductor's winding is used. The dependence of amplitude values of eddy current density and magnetic pressure on the surfaces of nonmagnetic plates of different electrical conductivity is investigated. The influence of the presence and absence of a ferromagnetic platform and its electrical conductivity and magnetic permeability on the values ​​of eddy currents and magnetic pressure in the nonmagnetic plate have been studied. Ref. 13, fig. 7, table.
DEVICE FOR CORRECTING THE LINE VOLTAGE WAVEFORM THAT FEEDS A HIGH-POWER CON-TROLLED RECTIFIER
Authors:   Institute of Electrodynamics of the National Academy of Sciences of Ukraine,  pr. Peremohy, 56, Kyiv, 03057, Ukraine, Chyzhenko O.I. , Blinov I.V. ,   Institute of Electrodynamics of the National Academy of Sciences of Ukraine,  pr. Peremohy, 56, Kyiv, 03057, Ukraine
Published: May 2022

A circuit solution of a device for correcting the waveform of the mains voltage, which feeds a controlled semiconductor rectifier of comparable power, is proposed. The sags and swells in the mains phase voltage, which occur during current switching from one phase to another, are compensated by correction pulses, which are transformed into these phases from the phase, which is not involved in switching, using transformers. The mains phase voltage correction circuit, which generates the correction pulses, is connected to the rectifier by four groups of gates in each phase. These groups contain two counter-parallel controlled thyristors, which connect the rectifier to the network phases and its neutral conductor. An algorithm for controlling the controlled thyristors is described. Ref. 8, fig. 2.
FEASIBILITY STUDY ON THE SELECTION OF PHASE DESIGN AND OVERHEAD LINE WIRE CROSS-SECTION
Authors:   Institute of Electrodynamics of the National Academy of Sciences of Ukraine,  pr. Peremohy, 56, Kyiv, 03057, Ukraine, Kuchanskyy V.V. , Lykhovyd Y.H. ,   Ukrenergo National Energy Company Private Joint-Stock Company,  St. Simona Petliury, 25, Kyiv, 01032, Ukraine
Published: May 2022

The paper analyzes the existing method of choosing the cross-section of wires by the method of an interval of economic curves. It is shown that the cross-section of the wires and the design parameters of the lines must correspond to the ratio between the cost of construction and the cost of optimizing the design of phase wires. The algorithm of application of this method for 330 kV power transmission lines with split phase is substantiated. A current load search algorithm has been developed and proposed, in which it is assumed to switch to the use of split-phase wires with minimal costs. Many arrays of curves are constructed, which allows for choosing the cross-section of wires and the conditions under which it is necessary to split the phase wire. Algorithms for selecting economically feasible wire cross-sections and methods for determining the conditions of profitability of overhead power lines are presented. The optimization of the cross-section and construction of the line phases was carried out, and the conditions of expedient phase splitting and application of lines of increased natural power were determined. The least-squares method was used to approximate the lower envelope. Ref. 9, fig. 3, table.
An Ethical Analysis of Newborn Congenital Cytomegalovirus Screening
Authors: Pesch Megan H. , Danziger Phoebe , Ross Lainie Friedman , Antommaria Armand H. Matheny
Published: May 2022

Congenital cytomegalovirus (cCMV) affects approximately 1 in every 200 US infants and can be associated with long-term neurodevelopmental sequelae, including sensorineural hearing loss, cerebral palsy, and intellectual disability. As cCMV is infrequently diagnosed based on clinical suspicion alone, newborn cCMV screening programs have been gaining traction, especially hearing-targeted programs which only test infants who fail their newborn hearing screen. cCMV screening programs raise unique ethical dilemmas of both under- and over-diagnosis of cCMV. In this Ethics Rounds, we present a case in which the parents of a child with symptomatic cCMV that was not recognized until 4 years of age urge the birth hospital to implement a cCMV screening program. We then ask a parent-clinician, a medical ethicist and pediatrician, and a primary care pediatrician to comment on how they would advise the hospital administration and consider the ethical and clinical implications of a cCMV screening program. The commentaries herein arrive at differing conclusions about cCMV screening. The first highlights the developmental advantages of early cCMV detection, supporting a broad approach to treatment beyond antiviral medication alone. The second explores cCMV screening from the perspective of newborn screening as a public health program, noting shortcomings in available testing platforms, and raising concerns about overdiagnosis and overtreatment. The final commentary challenges the risks of undue parental anxiety and vulnerable child syndrome as a barrier to screening, instead considering cCMV screening as a controlled opportunity to understand and support the experiences of affected children and their families.