bluuebunny/crossref_metadata_2025 huggingface dataset:
The Necessity of Human Papillomavirus Vaccination in Men: A Narrative Review
Authors: Kim Sooyoun , Bae Sangrak
Published: January 2025

Anogenital wart caused by human papillomavirus (HPV) is the most common sexually transmitted infection. High-risk strains, such as types 16 and 18, cause penile cancer in men, cervical and vulvar cancers in women, and head and neck cancers and anal cancer in both sexes. Since these malignant tumors can be prevented through vaccination, the importance of vaccination is emphasized. However, because HPV is known to cause cervical cancer, vaccination is only being administered to women. Some countries vaccinate men as well, but in South Korea, only girls are included in the National Immunization Program. However, screening for HPV in men is not possible, and the virus causes various malignant tumors, with a sharp increase in head and neck cancers, as well as a surge in genital warts in the country. In addition, HPV worsens sperm quality. Moreover, the need for vaccines is increasing as the known methods for preventing HPV-related diseases in men are decreasing and the disease burden is increasing. As cost-effectiveness studies have shown that the cost-effectiveness of vaccination is lower for men than for women, it is unlikely that male vaccination will be included in national immunization programs. Many countries overseas, especially a very small number of OECD (Organization for Economic Cooperation and Development) countries including South Korea, are implementing mandatory vaccination for women. Vaccinating men and women, would be cost-effective and efficient in achieving herd immunity. In addition to herd immunity, the inclusion of male vaccination in the National Immunization Program is imperative given the rapidly increasing incidence of diseases in men.
Category-activity puzzles as resources for humor in L2 classrooms
Authors: Çopur Nimet
Published: January 2025

Categories are inference-rich and do implicative work storing a great deal of knowledge that members of a society have about the society. Drawing on Membership Categorization Analysis, and sequential analysis from Conversation Analysis, this study explores participants’ categorial orientations in talk-in-interaction that is produced and/or treated as humorous in the Second Language (L2) classrooms. More specifically, this study presents an in-depth analysis of the way category-activity puzzles, which display incongruous combination of membership categories and category-bound activities, are formed, and made relevant and consequential in talk that is produced and/or treated as humorous. In doing so, it unpacks how participants invoke, negotiate, and deal with category-activity puzzles as resources for producing and/or treating utterances as humorous in L2 classrooms. The analysis will also illustrate the way participants use their understanding of common-sense knowledge and category memberships as a resource in managing and negotiating incongruities created through category-puzzles, which are treated as humorous. As such, this study contributes to the growing body of MCA and humor studies in classrooms and advances our understanding with regards to the categorial orientations of participants in L2 classrooms.
Evaluating the seismic out-of-plane capacity of unreinforced masonry walls: effects of cantilevered masses
Authors: Helm Lukas , Sadegh-Azar Hamid
Published: January 2025

Unreinforced masonry walls are highly susceptible to out-of-plane loads during seismic events. The rocking behavior of masonry walls under seismic loads is a nonlinear, time-dependent process, best represented by nonlinear dynamic time-history simulations. However, discrete modeling of complete wall systems – including bricks, mortar joints, and boundary conditions – is typically impractical. To achieve simplicity and precision, an idealized single-degree-of-freedom (SDOF) model is often preferred. Several authors have developed methods to determine the force-displacement relationship of unreinforced masonry walls, but experimental investigations have shown that critical influencing factors are often neglected. A new model has been developed to address these gaps, incorporating real-world parameters such as vertical stiffness and dynamic effects, and has been experimentally verified through shaking table tests. In the present work, the model is extended to include the effects of cantilevered loads, which significantly impact the structural behavior of walls. Dynamic analyses using real earthquake records reveal that higher cantilevered loads lead to earlier failures and greater deformations, particularly in slender configurations. These findings highlight the critical need for precise modeling and consideration of cantilevered loads in seismic design, especially for safety-critical structures like nuclear facilities.
The oldest farmers’ settlement from Poland. New interdisciplinary data on chronology and economy from the Gwoździec site
Authors: Czekaj-Zastawny Agnieszka , Rauba-Bukowska Anna , Kukułka Agnieszka , Craig Oliver E. , England Fiona , Kotula Andreas , Kufel-Diakowska Bernadeta , Lityńska-Zając Maria , Lucquin Alexandre , Moskal-del Hoyo Magdalena , Oberc Tomasz , Robson Harry K. , Wilczyński Jarosław
Published: January 2025

In der zweiten Hälfte des 6. Jahrtausends v. Chr. wanderten die ersten mit der Bandkeramik verbundenen Bauern aus und ihre Kultur verbreitete sich in die Gebiete nördlich der Karpaten. Bisher hatte man angenommen, dass diese frühneolithische Ausbreitung in einen Zeitraum um ca. 5500–5400 v. Chr. fällt, was sich vor allem auf vergleichende Studien der stilistischen Merkmale der Keramik stützte. Seit einiger Zeit gibt es jedoch bei zahlreichen Forschern Zweifel, ob die Art der Dekoration der Gefäße mit absoluten Daten übereinstimmt. Um dieses Problem anzugehen, führen die Autoren seit einigen Jahren ein Projekt über die älteste LBK-Siedlung nördlich der Karpaten durch. Ausgangspunkt ist die Stätte in Gwoździec. Die dort durchgeführten Forschungen und die aus interdisziplinären Analysen resultierenden Schlussfolgerungen erwiesen sich als äußerst wichtig für die gesamte Zone nördlich der Karpaten. Ihr Ergebnis ist eine Überarbeitung der Radiokarbonchronologie in Bezug auf den Keramikstil. Außerdem wurde eine große Menge neuer Daten über das Alltagsleben dieser Gemeinschaften gewonnen.
A INFÂNCIA INDÍGENA: PESQUISA COM CRIANÇAS NA ALDEIA CANUANÃ (FORMOSO DO ARAGUAIA - TO)
Authors: Polese Nathalia Cunha
Published: January 2025

O presente trabalho teve como principal objetivo investigar a maneira como as crianças indígenas da aldeia Canuanã transitam entre as suas culturas infantis e o universo cultural em que vivem; compreender a infância indígena a partir do olhar dos infantes e analisar a relação das crianças com os modos específicos de socialização da sua comunidade e com as influências interculturais presentes no seu contexto social. Para isto, optou-se pela pesquisa etnográfica na aldeia Canuanã (Formoso do Araguaia -TO), nos anos de 2012 e 2013, na qual se buscou uma perspectiva antropológica de desvelar este universo infantil a partir do olhar das crianças indígenas, utilizando como instrumento principal a observação participante. Também contamos com instrumentos lúdicos como produção de desenhos, andanças pela comunidade orientadas pelas crianças, fotografias, brincadeiras em geral. Os resultados da análise apontaram para três categorias que orientaram o presente estudo: o rio, os mitos e a educação bilíngue e intercultural, que estiveram presentes nas falas e no cotidiano daquele universo infantil.
SUCESSÃO E LIMINARIDADE: O CASO DO TERREIRO DA GOMEIA
Authors: Pereira Rodrigo
Published: January 2025

O presente trabalho visa apresentar o extinto Terreiro da Gomeia (Duque de Caxias/RJ). Por uma vertente abordaremos o histórico da formação do local e a liderança exercida pelo babalorixá Joãozinho da Gomeia. Por outro analisaremos, pelo referencial teórico de Victor Turner, as fases de um rito de passagem, em especial, desenvolveremos uma crítica sobre o postulado do autor quanto a manutenção da ordem social após o término do rito. O artigo focará na análise do evento de seu falecimento e no conflito sucessório instaurado após isto. Descreveremos os grupos de interesse relacionados a disputa de liderança e como isso resultou no fechamento do Axé e a abertura de outra casa de candomblé com o mesmo nome, ação realizada por um grupo considerado dissidente.
NECESSIDADE DE MAIOR CRÍTICA ÀS FONTES HISTORIOGRÁFICAS SOBRE OS ÍNDIOS NO BRASIL: CONTRIBUIÇÕES À ETNO-HISTÓRIA, ETNOARQUEOLOGIA E À ARQUEOLOGIA PRÉ-HISTÓRICA
Authors: Deminicis Rafael Borges
Published: January 2025

As analogias feitas pelo uso de fontes historiográficas (mapas, imagens, manuscritos etc.), principalmente as que abordam os povos indígenas encontrados no Brasil, sem uma metodologia crítica de análise dessas fontes, têm criado algumas armadilhas aos estudos nos campos da etno-história e da etnoarqueologia. Portanto, o que poderia auxiliar no descobrimento da história e das identidades étnicas das inúmeras sociedades tribais remotas ou indígenas sul-americanas, traz cada vez mais encobrimento. Neste sentido, uma dialética serial das fontes se faz extremamente necessária. O panorama do que existe acumulado no Brasil sobre métodos de crítica das fontes historiográficas sobre as sociedades indígenas é extremamente raro, resumindo-se a duas referências: o trabalho de síntese dos grandes contextos sociais de produção das fontes criado pelo sociólogo Florestan Fernandes; e o sistema de observação das particularidades das fontes, a “sociologia dos viajantes”, do antropólogo João Pacheco de Oliveira. Um primeiro passo na direção de uma dialética e serial às referidas fontes seria a combinação desses dois métodos.
RECURSOS NATURAIS E COTIDIANO: POPULAÇÃO RIBEIRINHA E A GESTÃO DA RDS ALCOBAÇA – UHE TUCURUÍ/PA
Authors: Almeida Neila de Jesus Ribeiro , Cañete Voyner Ravena
Published: January 2025

A implantação de hidrelétricas na Amazônia brasileira tem ocasionado sérios problemas socioambientais - processo migratório de populações de várias regiões do país, impactos negativos sobre o meio ambiente e em comunidades tradicionais que sobreviviam diretamente dos recursos extraídos da área atingida.  Embora medidas mitigadoras desses impactos estejam sendo desenvolvidas, pode-se observar a ineficácia da gestão nessas áreas. Este artigo analisa os impactos socioambientais provocados pela construção da Usina Hidrelétrica de Tucuruí na Amazônia paraense, especificamente em uma Unidade de Conservação de Uso Sustentável - Reserva de Desenvolvimento Sustentável Alcobaça. Usando entrevistas e observação direta a pesquisa se debruça especialmente sobre o cotidiano da população ribeirinha da reserva, descrevendo os aspectos de formação do lago e a realidade contemporânea dessas populações afetadas por mais um projeto desenvolvimentista implementado na Amazônia brasileira.
MOVILIZACIONES INDÍGENAS Y PROTESTAS SOCIO-AMBIENTALES EN EL SALAR DE ATACAMA-NORTE DE CHILE
Authors: García Paola Bolados , Boccara Guillaume
Published: January 2025

Después del retorno a la democracia en Chile -a fines del siglo pasado-, se inicia un proceso de reconocimiento formal de los pueblos originarios a través de una política indígena y multicultural. No obstante, esta coincidió con el avance y la consolidación del modelo neoliberal impuesto durante el régimen militar a mediados de la década de 1970, el cual continuó privatizando recursos naturales concentrados en territorios indígenas. En este trabajo mostramos como este neoliberalismo multicultural desplegado en un contexto de nuevas privatizaciones, fue contestado y resistido por las poblaciones indígenas atacameñas en el norte de Chile a mediados de la primera década del nuevo siglo, poniendo en crisis las relaciones con el estado y las empresas -principalmente mineras y turísticas-, presentes en su territorio. Nos centramos en las luchas emprendidas por las comunidades atacameñas a mediados del 2000 y sus intentos por recuperar los recursos naturales y culturales mercantilizados bajo un discurso de derechos indígenas y ambientales propagado por los gobiernos socialistas de Ricardo Lagos (2000-2006) y Michelle Bachelet (2006-2010).
POVOS INDÍGENAS, SOCIEDADE MODERNA E PROJETOS (DITOS) DE DESENVOLVIMENTO NACIONAL
Authors: Caldeira Vanessa Alvarenga
Published: January 2025

Este artigo tem como objetivo apresentar uma reflexão sobre a condução de processos de licenciamento ambiental de empreendimentos localizados em áreas incidentes ou próximas a terras indígenas no Brasil. A análise se baseia em trabalhos de consultoria realizados na área de licenciamento ambiental, em pesquisa bibliográfica, bem como em acompanhamento do tema junto aos movimentos indígenas e ao poder público. O artigo analisa o atual modelo de licenciamento ambiental vigente no país; a prática comum de concessão de licenças ambientais sem que estudos de componente indígena tenham sido realizados ou concluídos; e a resistência do Estado brasileiro e de empreendedores em efetivamente ouvirem os povos indígenas nesses processos.
ESTÉTICA E EXPERIÊNCIA DO GOSTO: contribuições para o debate sobre paladar, gastronomia e arte
Authors: Benemann Nicole Weber
Published: January 2025

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RELAÇÕES DO ALIMENTAR E RELAÇÕES QUE ALIMENTAM: El Tambo e a Mamacocha no norte do Peru
Authors: Peñafiel Adriana Paola Paredes
Published: January 2025

Neste artigo analiso a noção do alimentar dos camponeses do centro poblado El Tambo que se organizam para vigiar continuamente a lagoa Mamacocha que está localizada na região do Conga, onde será instalado um projeto de mineração a céu aberto com o mesmo nome. A partir de pesquisa de abordagem etnográfica entre 2013 e 2014, observei que a relacionalidade dos camponeses com a lagoa Mamacocha é ativada pela realidade da experiência vivida com a água, mas que é coproduzida com histórias orais e com encontros com ambientalistas. O alimentar é a palavra que emerge nos meus diálogos com os camponeses onde se torna visível uma cadeia complexa de eventos que leva a uma firme oposição contra o projeto de mineração Conga. Ao mesmo tempo, um novo e dinâmico território se torna visível onde Mamacocha tem um papel fundamental e é por isso que os camponeses estendem o seu papel para com a comunidade como Guardiões das Lagoas.
RESILIENCIA Y CAMBIOS DEL SISTEMA PRODUCTIVO EN LA AGRICULTURA FAMILIAR DE LA NUEVA RURALIDAD EUROPEA: el caso del queso de oveja en la Sierra de Cádiz (España)
Authors: López Moreno Ignacio , Aguilar Criado Encarnación
Published: January 2025

El presente artículo analiza las estrategias surgidas dentro de los sistemas productivos de la agricultura familiar como respuesta a desequilibrios generados por cambios normativos formales. La metodología de la investigación se ha basado en la etnografía, siguiendo las técnicas de entrevistas y observación participante características del trabajo de campo en antropología social. Esta estrategia, fundamentalmente cualitativa, nos permitió analizar las consecuencias de las transiciones de productos propios de economías domésticas y sistemas agrarios tradicionales, a la economía de la calidad que caracteriza a la Nueva Ruralidad europea que ha tenido un especial desarrollo en España por la fuerte implementación de las Iniciativas Europeas LEADER I, II y + desde 1991. Para ello, y partiendo de una perspectiva compleja y sistémica, estudiamos distintos sistemas productivos de las familias productoras de queso de la Sierra de Cádiz, esta perspectiva permite analizar las transformaciones que dieron lugar a la generación de dos modelos diferentes pero complementarios: el artesanal y el industrial. Nuestro trabajo demuestra la resiliencia de las economías familiares de productores queseros tradicionales, que siguen conviviendo con nuevos productores industriales dentro del competitivo mercado de los productos agroalimentarios de calidad. La persistencia de unos y la aparición de otros, demuestra la capacidad de adaptación de las economías rurales a los nuevos retos de la globalización y la complejidad de la Nueva Ruralidad.
PARA TURISTA VER (E PROVAR): dos usos do patrimônio gastronômico no contexto do turismo
Authors: Gimenes-Minasse Maria Henriqueta S. G.
Published: January 2025

As práticas alimentares e seus serviços tem importância fundamental para o desenvolvimento do turismo, atuando tanto como serviço essencial quanto atrativo turístico. Uma vez reconhecida como uma prática cultural, a alimentação torna-se elemento de grande importância para a diferenciação e competividade de alguns destinos turísticos. Este ensaio, escrito com o apoio de uma pesquisa bibliográfica, traz reflexões sobre o processo de transformação de elementos do patrimônio gastronômico em atrativos turísticos e os efeitos desse processo, comentando exemplos que retratam modificações na forma de produção e consumo de alimentos, bem como alterações nos hábitos alimentares locais causados pelo desenvolvimento da atividade turística.
¿PORQUE SEGUIMOS COMIENDO LOS ALIMENTOS DE LA CHACRA? Sentidos de los alimentos en el noroeste argentino
Authors: Sammartino Gloria Verónica
Published: January 2025

Las conductas ligadas a la alimentación son dinámicas, están afectadas por las condiciones socioeconómicas y políticas que inciden en las prácticas y los sentidos alimentarios. Sin embargo los ritmos de estos cambios están influenciados por los valores grupales y las prácticas del pasado que inciden en la perdurabilidad de ciertos elementos que parecerían poder resistir a las innovaciones e introducción de variedades y tecnologías nuevas. En este artículo analizamos los significados alimentarios que emergen del análisis de  relatos de personas de una región del noroeste argentino, la Quebrada de Humahuaca, provincia de Jujuy, con el propósito de visualizar algunos aspectos claves para el esbozo de explicaciones acerca de las situaciones concretas que inciden en las continuidades y modificaciones alimentarias, en la que se ponen en tensión las relaciones dadas en el marco de la expansión de la producción y consumo masivo de alimentos que provienen de las cadenas agroalimentarias hegemónicas, junto a modalidades de producción y consumo de alimentos que, con graduaciones, escapan a dicha lógica, pues existe una esfera de producción de alimentos orientada al autoconsumo.
TENDÊNCIAS NO MOVIMENTO DE RE-LOCALIZAÇÃO ALIMENTAR BRASILEIRO: uma análise de Iniciativas Colaborativas de Compras
Authors: Preiss Potira Viegas , Marques Flávia Charão
Published: January 2025

Este artigo tem como objetivo apresentar uma caracterização do cenário brasileiro de Iniciativas Colaborativas de Compras. Inspira-se em dados coletados em levantamento realizado em 2014, complementados por uma revisão da literatura. A partir do perfil básico dos grupos e suas dinâmicas de funcionamento são tecidas considerações sobre o impacto que o envolvimento em tais iniciativas têm para com as práticas sociais dos atores envolvidos. Também, introduzimos um breve diálogo entre as convergências e as divergências em torno de iniciativas brasileiras e iniciativas similares atuantes na Europa, contribuindo para o debate de como estas experiências podem trazer aportes ao movimento de re-localização alimentar.
COMIDA PARA PENSAR: apresentando um dossiê...
Authors: Menasche Renata , Collaço Janine Helfst Leicht , Tempass Mártin César
Published: January 2025

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Application of a macrocyclization strategy in kinase inhibitor development
Authors: Xing Kun , Li Shujun , Li Jinghuan , Liu Dan , Huang Min , Zhao Linxiang
Published: January 2025

Kinases have a pivotal role in phosphorylation and kinase dysregulation has been implicated in the occurrence and progression of various diseases. By mid-2024 the Food and Drug Administration had approved 81 small-molecule kinase inhibitors targeting greater than 30 kinases, providing substantial clinical benefits for patients with cancer and other diseases. However, many reported kinase inhibitors exhibit poor target selectivity, limited solubility, and issues with drug resistance. To address these challenges medicinal chemists have used a macrocyclization strategy to optimize these molecules and three macrocyclic kinase inhibitors (lorlatinib [ALK/ROS1], pacritinib [Flt3/JAK2], and repotrectinib [TRK/ROS1]) have received FDA approval. The macrocyclization strategy is now widely used to enhance kinase inhibitory activity, overcome drug resistance caused by point mutations, improve kinase selectivity, and optimize drug-like properties. In this review we provide a comprehensive overview of the utilization of macrocyclization in the optimization of kinase inhibitors by detailing the structural modification process from lead compounds to macrocyclic molecules that has been applied in recent years. In addition, we discuss the limitations of existing macrocyclic kinase inhibitors and propose key considerations for the development of improved macrocyclic molecules. We aim for this review to offer valuable insights for future advances in kinase inhibitor development.
Thirty years of StAR gazing. Expanding the universe of the steroidogenic acute regulatory protein
Authors: Miller Walter L
Published: January 2025

The current understanding of the biology, biochemistry and genetics of the steroidogenic acute regulatory protein (StAR) and its deficiency state (lipoid congenital adrenal hyperplasia, lipoid CAH) involves the complex interplay of four areas of study: the acute regulation of steroidogenesis, clinical phenomena in lipoid CAH, the enzymatic conversion of cholesterol to pregnenolone in steroidogenic mitochondria, and the cell biology of StAR. This review traces the origins of these areas of study, describes how they have been woven into an increasingly coherent fabric and tries to explore some remaining loose ends in this ongoing field of endocrine research. Extensive research from multiple laboratories has established that StAR is required for the rapid, abundant steroidal responses of the adrenals and gonads, but all steroidogenic cells, especially the placenta, also have StAR-independent steroidogenesis, whose basis remains under investigation. Lipoid CAH is the StAR knockout of nature whose complex (and unexpected) clinical features are explained by the ‘two-hit model’, in which StAR-dependent steroidogenesis and StAR-independent steroidogenesis are lost sequentially. StAR is targeted to mitochondria and acts on the outer mitochondrial membrane before being imported via the ‘translocase of outer membrane’ system and is then inactivated by mitochondrial proteases. A role for the ‘translocator protein’ (TSPO) has long been proposed, but an essential role for TSPO is excluded by recent transgenic mouse experiments. Crystal structures show that a StAR molecule can bind one cholesterol but does not explain how each StAR molecule triggers the import of hundreds of cholesterol molecules; this is the most pressing area for future research.
Heurísticas para la evaluación de sitios web de bibliotecas universitarias
Authors: Valenzuela Cristian , Oliveros Sergio , Reyes-Lillo Danilo , Valdenegro Boris , Núñez Claudia
Published: January 2025

In this article, a detailed review of the research that works on usability heuristics to examine the web spaces of university libraries is proposed. The objective is to detect the usability heuristics necessary to evaluate the websites of university libraries, according to scientific literature, between 2012 and 2022. The research was developed using the systematic review methodology, specifically the scoping review modality, applied to six bibliographic databases. Among the results, it is established that there are three categories of heuristics: matching, non-matching and those that have been expressly designed for university libraries. It is concluded that the development of heuristics for university libraries is incipient and that the analysis of a space as complex as this requires a layered heuristic evaluation and the application of different evaluation instruments depending on the purpose of the service and the content of the website.
MARCHA HUMANA Y DEPORTE EN DE INCESSU ANIMALIUM DE ARISTÓTELES. EL SALTO CON PESAS DE LOS GRIEGOS
Authors: RODRÍGUEZ LÓPEZ Juan
Published: January 2025

El artículo selecciona y analiza las explicaciones sobre la marcha humana en De Incessu Animalium de Aristóteles, sus principios explicativos, especialmente los referidos a que a) “la naturaleza hace siempre lo más adecuado y no se queda corta en su tarea” según las posibilidades de cada animal; b) las dimensiones corporales aristotélicas, especialmente la dimensión “alto-bajo”, que distingue la marcha bípeda y bípedo-erguida humana, de las del resto de los animales y la dimensión derecha-izquierda, debido a que en el humano y en todos los animales el “origen del movimiento está en la derecha”. Se aplica este principio a la preferencia generalizada, aparentemente contradictoria, de los saltadores de longitud diestros de realizar su batida con el pie izquierdo. Se analiza la extensa comparación que Aristóteles realiza entre la marcha humana y la de las aves y cuadrúpedos. Finalmente, a partir de la afirmación de Aristóteles en De Incessu Animalium de que “los saltadores saltan más con pesas que sin ellas”, se investiga la forma del salto griego de la antigüedad, proponiendo como hipótesis compatible con las fuentes históricas y experimentos recientes, el salto quíntuple con carrera previa, batida con un solo pie (necesaria por coordinación con la carrera previa y contrastada con las fuentes) y posteriores cuatro saltos a pies juntos.
ЭВОЛЮЦИЯ ПРЕДСТАВЛЕНИЙ О САМООРГАНИЗАЦИИ В ХИМИЧЕСКИХ СИСТЕМАХ: ОТ КИНЕТИЧЕСКИХ ТЕОРИЙ К СИНЕРГЕТИКЕ
Authors: ГОРДЕЕВ А.Ю. , МУКИН В.А.
Published: January 2025

Статья посвящена истории зарождения, роста и трансляции научного знания, связанного с фундаментальными аспектами самоорганизации в химических системах, начиная от роли кинетических теорий и заканчивая применением современных технологий и методов исследования. Цель работы заключается в системном обосновании закономерности самоорганизации в химии. Кроме того, выявлены и обоснованы основные принципы и механизмы синергетического подхода к химическому исследованию. Предложен комплекс логически структурированных операций, направленных на генерирование новых научных знаний в области химии. Показано, что синергетический подход открывает возможность получения знаний, выходящих за пределы ожидаемого научного результата.

The article deals with the history of the origin, growth and translation of scientific knowledge related to the fundamental aspects of selforganization in chemical systems, starting from the role of kinetic theories and ending with the use of modern technologies and research methods. The purpose of the work is to systematically substantiate the patterns of selforganization in chemistry. In addition, the basic principles and mechanisms of the synergistic approach to chemical research are identified and substantiated. A set of logically structured operations aimed at generating new scientific knowledge in the field of chemistry is proposed. It is shown that the synergetic approach opens up the possibility of obtaining knowledge that goes beyond the expected scientific result.
Critical Examination of Gender Equality in Responsible Research and Innovation context: A Bibliometric Analysis
Authors: Bagočiūnė Laura
Published: January 2025

Introduction. Responsible Research and Innovation (RRI) is increasingly crucial for addressing societal challenges and promoting sustainable economic growth. While RRI principles have been institutionalized in Europe, gender equality (GE) within this framework remains underexplored. GE policy in the European Union (EU), rooted in gender mainstreaming since 1999, addresses socially constructed roles shaped by intersecting factors like race and class. Recognized as a human right and vital for sustainable development, GE enhances participation, eliminates barriers, and integrates gender perspectives into research. This study examines the integration of GE within the RRI framework to address this gap.
Method. A two level bibliometric analysis was conducted using Scopus and Web of Science (WoS) databases, focusing on English-language, open-access articles published between 1985 and 2024. Following the application of exclusion criteria, a total of 2134 documents were analyzed, comprising 2045 in Phase 1 and 89 in Phase 2.
Analysis. The analysis revealed a significant underrepresentation of GE within the RRI discourse. Despite a growing interest in RRI, there is a lack of meta-analytical studies focusing on GE, with research predominantly addressing broader aspects of RRI.
Results. From the 2134 documents analyzed, only 89 explicitly addressed GE within the RRI context. Co-occurrence networks identified four primary RRI clusters emphasizing sustainability, governance, education and ethics. GE related keywords formed smaller, peripheral clusters, indicating marginal representation. The findings underscore a lack of systemic integration of GE into the broader RRI framework.
Conclusions. The study highlights the critical need to prioritize GE within the RRI agenda by embedding it across all its dimensions. Addressing this gap will enhance the inclusivity, societal relevance, and ethical alignment of RRI initiatives. Policymakers and institutional leaders must champion GE as a foundational element of RRI to advance sustainable and equitable innovation.
Kamilla’s Letter to Aleksandra, or Not Just a Letter
Authors: Griškaitė Reda
Published: January 2025

In this publication, the letter-manifesto of the writer Kamilla z Narbuttów Jurewiczowa (or Kamilla Na­rbuttówna vel Kamilla Narbutt, ~1815–1881), first published in 1852 in Vilnius, is presented. It explores the issues of gender equality, woman’s freedom(s) and powers, as well as questions of women’s education, which are closely related to the still-sensitive problem of a writing woman. Both the original letter-manifesto in Polish and its translation into Lithuanian (with subject-related commentaries) are provided to the reader.
Conceptual Principles for Researching the Demographic Resilience of Ukrainian Society
Authors: OLEKSANDR GLADUN , IRYNA KURYLO , DMYTRO SHUSHPANOV , SVITLANA AKSYONOVA , OLEKSII POZNIAK
Published: January 2025

Theoretical and practical aspects of demographic resilience have been studied by many scientists across different countries. However, for each country, these issues require tailored analysis and adaptation to specific conditions. The purpose of this study is to determine the place of demographic resilience and its components, analyze them with adaptation to Ukraine’s particular conditions in order to form the key directions of achieving the resilience of Ukrainian society in the post-war period. The primary methods used in this research include abstract-logical, sociological, classification-analytical methods and synergistic approach. The novelty of the study lies in the development of conceptual foundations for analyzing the demographic resilience of Ukrainian society in the current context. The authors’ definition of demographic resilience is provided: it is explained as the ability to ensure the change of generations, maintain the desired demographic balance, maintain basic functions and social structures, minimizing the negative consequences of destructions and contributing to recovery. The following components of demographic resilience are proposed: reproductive resilience, resilience of age and sex population structure, family resilience, social or age group resilience, life preservation, resilience of the healthcare system, and migration resilience. The relationships between these components and economic and social resilience, education, and the realization of the “demographic dividend” are analyzed. Criteria for assessing the components of demographic resilience are proposed. Healthcare system resilience and health resilience are treated as distinct components of demographic resilience, yet they are closely interconnected. Both are integrated and influenced by various factors. The migration component is examined in the context of immigration, emigration, and the accommodation and adaptation of internally displaced persons. Demographic resilience in Ukraine has been influenced by both the COVID-19 pandemic and, more significantly, the full-scale Russian-Ukrainian war. Their effects cause the need for further quantitative assessment of the individual components of demographic resilience and the development of specific measures to strengthen it.
Ensuring Resilience of Social Support for the Population of Ukraine During Hybrid Crises and Disasters
Authors: LIUDMYLA CHERENKO , ANNA REUT , YULIIA KLYMENKO
Published: January 2025

The article provides an overview of the challenges and specific features of the social support system’s functioning during a crisis period. The highlighted problems include the following: first, Ukraine’s state social obligations have traditionally exceeded the financial and economic capacity to fulfill them for decades; second, the outdated model of social support, which does not guarantee the resilience of the quality of life; third, the low social return of the main support programs for the population reduces the effectiveness of assistance, even in a relatively stable environment; fourth, the imperfect mechanism and low level of institutionalization of monitoring and evaluation of the social support system hinder effective reform and prompt transformation of the system during crises. The authors identified the main needs and vulnerable groups in the context of state social support provision. The pandemic and the war have exacerbated the gap between the needs of vulnerable groups and the system’s capabilities, thus creating additional challenges. The novelty of the study lies in interpreting the resilience of social support from two perspectives: ensuring the self-sufficiency of the system during periods of hybrid crises and disasters, and its ability to foster societal resilience through supporting vulnerable groups. The aim of the work is to identify the key issues of Ukraine’s social support system that prevent timely and effective responses to challenges during periods of hybrid crises and disasters, as well as to assess the system’s self-sufficiency and its role in ensuring the resilience of Ukrainian society. The study used bibliometrics, economic-statistical, monographic, statistical, calculation methods, as well as methods of qualitative and comparative analysis, modeling and abstract-logical method.

It is determined that the successful resolution of the existing problems in the social support system and ensuring its resilience during crises is possible by adhering to the principle of the relevance of assistance to the recipient when providing support. During crises, this can be achieved through effective management of a limited number of social programs, achieving their universality regardless of the nature of the crisis, and ensuring the timely implementation of new short-term measures. In crisis situations, it is necessary to have information that is promptly received and allows for tracking the real state of affairs, changes, and current needs. It is important to institutionalize the monitoring process and implement its results into practice during the reform of social assistance programs and when choosing policy directions. This will ensure the resilience of the system and the quality of life for the population by optimizing costs, increasing social returns, targeting, and timely assistance.
CONCERNING THE LATENT INFECTION PROGRAMS OF EPSTEIN-BARR VIRUS IN B-CELLS OF CHRONIC LYMPHOCYTIC LEUKEMIA
Authors:   RE Kavetsky Institute of experimental pathology, oncology and radiobiology of National Academy of sciences of Ukraine,, Kovalevska L. , Matveeva A. ,   RE Kavetsky Institute of experimental pathology, oncology and radiobiology of National Academy of sciences of Ukraine,, Tytorenko I. ,   The state non-profit enterprise “National Cancer Institute”, Kyiv, Ukraine, Kryachok I. ,   The state non-profit enterprise “National Cancer Institute”, Kyiv, Ukraine
Published: January 2025

The treatment of hematological diseases is one of the most complex problems of modern medicine. It is known that humoral immunity is based on B-lymphocytes, which at the terminal stages of differentiation turn into antibody-forming immunoblasts and plasma cells. Chronic lymphocytic leukemia (CLL) develops with a significant increase in phenotypically mature but immunocompetent B lymphocytes, that are characterized by the presence of atypical patterns of marker expression. The reasons for the inhibition of the cell signaling pathway responsible for proliferation and apoptosis in mature B lymphocytes of patients with CLL are extremely important, but still poorly understood. In-depth analysis of the key players of signaling cascades and transcription factors that are functionally suppressed in CLL will improve the prognosis of the disease and help develop personalized treatment for such patients.
Advances in the Treatment of Neonatal Coarctation of the Aorta
Authors: Hysko Klea , Bertram Harald , Bobylev Dmitry , Horke Alexander , Hansmann Georg
Published: January 2025

Coarctation of the aorta (CoA) is a potentially life-threatening congenital and obstructive anomaly of the distal aortic arch. After constriction of the ductus arteriosus, neonates may develop critical CoA in the isthmus area and present with severe left ventricular dysfunction or even cardiac failure. Low cardiac output and abdominal hypoperfusion (distal to the coarctation) may lead to metabolic derangements and clinical deterioration.

Most neonates can be adequately stabilized with critical care support; however, patients who demonstrate treatment-resistant left ventricular dysfunction and end organ damage are often considered too unstable for primary surgical CoA repair. In this particular setting, transcatheter intervention is often regarded as more beneficial than prolonged intensive care. Specialized centers have proposed different approaches to critical CoA treatment. Nevertheless, individual therapy decisions are based on patient condition as well as the experience and expertise of the interdisciplinary team. This article focuses on isolated neonatal CoA (as opposed to CoA in complex congenital heart disease). Advances in neonatal diagnosis, critical care, transcatheter interventions, and surgical techniques have led to lower mortality and reintervention rates and have improved outcomes in neonates with critical CoA.

Issues requiring further study include the optimal timing of definitive surgical CoA repair and the question how the severity of aortic obstruction and the choice of surgical technique affect long-term neurologic outcome.
The London Art of Plagiarisn, Part One
Authors: Lucraft Fiona
Published: January 2025

In 1783 a book called The London Art of Cookery and Housekeeper's Complete Assistant was published, as the work of 'John Farley, Principal Cook at the London Tavern'. It was a popular success and had reached its 12th edition by 1811. 
In 1989 the author of this essay, an enthusiastic amateur cook with literary and historical interests, borrowed simultaneously from a library a reprint of Farley's book and a reprint of Elizabeth Raffald's The Experienced English Housekeeper. 
As a result, one of the boldest and biggest and most cunning acts of plagiarism in the whole history of cookery books has, after 200 years of successful deception, been exposed. 
We particularly asked Fiona Lucraft to describe her detective work in detail, not only because of its intrinsic fascination but also because the details throw interesting light on a host of subsidiary matters.
Znaczenie regulacji prawnych w dobie kryzysu gospodarczego. Wybrane zagadnienia
Authors: Jastrzębski Robert
Published: January 2025

Artykuł podejmuje kwestię znaczenia regulacji prawnych w okresie kryzysu gospodarczego, w szczególności wpływu stanowionego prawa na przebieg kryzysu. Tekst składa się z czterech części. Pierwsza z nich dotyczy pojęcia kryzysu ekonomicznego oraz cykliczności tego zjawiska, w tym kryzysu ekonomicznego w krajach socjalistycznych. W drugiej zwrócono uwagę na pojęcie ustawodawstwa, ekonomicznej analizy prawa oraz zagadnienie wpływu ustawodawcy na przebieg koniunktury gospodarczej. Trzecia część zawiera przykłady regulacji kryzysowych oraz opisuje ich wpływ na proces kryzysu. Podane w niej zostały przykłady dotyczące m.in. lichwy wojennej, wielkiego kryzysu gospodarczego lat 30., tj. programu reform ekonomicznych w Stanach Zjednoczonych (New Deal), oraz ustawodawstwa antykryzysowego w państwie polskim sprzed drugiej wojny światowej, które dotyczyło przede wszystkim tzw. akcji finansowo-rolnej, akcji oszczędnościowo-oddłużeniowej samorządu terytorialnego, kredytu długoterminowego oraz ustawodawstwa antykartelowego. Ponadto zwrócono uwagę na kryzys finansowy 2008 r. oraz kryzys wynikający z ogólnoświatowej epidemii koronawirusa, która wybuchła w listopadzie 2019 r. W przypadku ostatniego z kryzysów omówione zostały tzw. tarcze antykryzysowe, które miały głównie charakter moratoryjny (odroczeniowy), zwolnieniowy oraz ulgowy. W podsumowaniu stwierdzono, że ustawodawstwo antykryzysowe ma wyjątkowy charakter oraz zwykle narusza podstawowe zasady prawa. Poza tym ustawodawstwo to charakteryzuje się doraźnym przeciwdziałaniem objawom kryzysu i ma charakter etapowy. Na zakończenie zaznaczono, że państwo przy pomocy legislacji nie jest w stanie zmienić przebiegu koniunktury gospodarczej, a co za tym idzie, wydać aktów prawnych, które zlikwidują jakikolwiek kryzys.
Courtroom Theatrics in the Letter of James
Authors: Batten Alicia J.
Published: January 2025

Since the eighteenth century, interpreters of the Letter of James have pointed to a judicial assembly as the envisaged background for Jas 2:1–7. In particular, commentators have identified rabbinic examples as parallels for the type of setting that the letter describes. However, one can also consider Jas 2:1–7 in light of the theatricality of the Roman courtroom. Theatrics figured centrally in Roman social and political life. In Roman juridical contexts visual effects such as gestures and dress functioned importantly for the outcome of a trial. In this study I consider Jas 2:1–7 in comparison with court proceedings and legal issues, but with a focus on the dress of the man in “shining clothes” (ἐσθῆτι λαμπρᾷ) and the poor man in “dirty clothes” (ῥυπαρᾷ ἐσθῆτι). I explore the peculiar Roman practice of donning “filthy” (sordes) dress as a means of procuring support from jurors and judges, who themselves were susceptible to participating in partiality. I argue that a court setting makes the most sense for Jas 2:1–7: Why else would the letter writer include these details of dress?
DIESEL SPRAY CHARACTERISTICS OF MULTI-HOLE INJECTORS UNDER GEOMETRICAL SIMILARITY CONDITION
Authors: Jin Yu , Zhang Yifan , Dong Pengbo , Zhai Chang , Nishida Keiya , Wang Yang , Leng Xianyin
Published: January 2025

Small-bore engines are popular due to low CO2 emissions and low fuel consumption. To simplify the
design steps for various engine sizes, similarity theory was applied to engines. In this paper, the spray
characteristics of non-evaporating sprays for multi-hole diesel injectors under the geometrical similarity
condition were investigated by diffused background illumination (DBI). The similarity theory is
based on Chikahisa theory, Wakuri momentum theory, and Inagaki analysis of geometrical similarity.
Under the similarity condition, the injectors with hole diameters of 0.07, 0.101, and 0.133 mm were
used at injection pressures of 45, 93, and 160 MPa, respectively. In addition, the injection pressure of
160 MPa was set as the same injection pressure condition for comparison. The results show that under
the similarity condition and the same injection pressure conditions, spray tip penetration, spray angle,
and other parameters follow the same trend of variation of hole diameters, except for the air-fuel ratio.
The scaled spray tip penetration and the scaled spray cone angle (the angle at 30 times the hole diameters
from the nozzle tip of the injector) of the three injectors under the similarity condition are well
matched. However, for the injector with a hole diameter of 0.133 mm, the scaled spray angle (the angle at half of the spray tip penetration) is larger than others at the start of the injection, and the scaled air-fuel
ratio is larger throughout the process. The difference in internal flow is responsible for the variation
of the scaled spray parameters of the injector with 0.133 mm hole diameter compared to the others.
Coriolis effect mitigation for single particle motion in centrifugal hypergravity field
Authors: Zhao Y. , Liu J. C. , Zhan Z. S. , Liang T. , Luo Y. X. , Shi C. Y.
Published: January 2025

The Coriolis effect, induced by centrifugal hypergravity, can significantly distort granular flow when studying the rapid flow characteristics of landslides and debris avalanches using centrifuge modelling approaches. This effect can either modify flow density or alter trajectory paths depending on flume arrangement, thus leading to inaccuracies in experimental outcomes. In this study, a lateral tilting method is proposed to mitigate the Coriolis effect for single particle motion in vertically arranged flumes, aiming to rectify the particle’s trajectory. The theoretical formulas for this method are initially derived, followed by validation through centrifugal hypergravity experiments and discrete element method simulations. The results indicate that the proposed method can reduce the offset of particle trajectory induced by Coriolis force to a certain extent. Specifically, when the flume is tilted laterally by 9°, the particle’s trajectory shows minimal offset, closely resembling the trajectory under normal gravity conditions. Moreover, theoretical results indicate that the single particle trajectory is independent of the g-level.
Exploration on Issues Related to Welfare of Medical Personnel in Grassroots Hospitals
Authors: Gao Junchen , Zhang Jian , Lv Moqi , Ge Pan , Yang Yanqi , Zhang Nan , Zhou Dangxia
Published: January 2025

Grassroots hospitals, like other medical service institutions, are public welfare undertakings that the government provides services to the people. Because of its own close to home, quick medical treatment, good effect, grassroots hospitals has an important role in the treatment of small diseases. However, this feature also brings the drawbacks of heavy tasks, low pay and low status for medical workers, which directly lead to the difficulties in the introduction of outstanding talents and the loss of current workers. In view of this situation, this paper discusses how to supplement the existing programs to solve these problems through literature comparison, puts forward the program of improving welfare benefits, and bring views on the existing problems and how to further improve the living standards of grass-roots doctors