bluuebunny/crossref_metadata_2025 huggingface dataset:
Lateral Flow Immunoassay for Visible Detection of Human Brucellosis Based on Blue Silica Nanoparticles
Authors: Ge Lirui , Wang Dan , Lian Fengnan , Zhao Jinbin , Wang Yue , Zhao Yuyi , Zhang Lanting , Wang Juan , Song Xiuling , Li Jinhua , Xu Kun
Published: December 2021

Brucellosis is a highly contagious zoonosis chronic infectious disease with a strong latent capability to endanger human health and economic development via direct or indirect ways. However, the existing methods for brucellosis diagnosis are time-consuming and expensive as they require a tedious experimental procedure and a sophisticated experimental device and performance. To overcome these defects, it is truly necessary to establish a real-time, on-site, and rapid detection method for human brucellosis. Here, a lateral flow immunoassay (LFIA) with a rapid, sensitive, and alternative diagnostic procedure for human brucellosis with a high degree of accuracy was developed based on blue silica nanoparticles (SiNPs), Staphylococcal protein A (SPA), and surface Lipopolysaccharide of Brucella spp. (LPS), which can be applied for rapid and feasible detection of human brucellosis. To our knowledge, this is the first report that uses blue SiNPs as a signal probe of LFIA for the rapid diagnosis of human brucellosis. The precursor of blue SiNPs@SPA such as colorless SiNPs and blue SiNPs was synthesized at first and then coupled with SPA onto the surface of blue SiNPs by covalent bond to prepare blue SiNPs@SPA as a capture signal to catch the antibody in the brucellosis-positive serum. When SPA was combined with the antibodies in the brucellosis-positive serum, it was captured by LPS on the test line, forming an antigen–antibody sandwich structure, resulting in the T line turning blue. Finally, the results showed that it is acceptable to use blue SiNPs as visible labels of LFIA, and standard brucellosis serum (containing Brucella spp. antibody at 1,000 IU/ml) could be detected at a dilution of 10−5 and the detection limit of this method was 0.01 IU/ml. Moreover, it also demonstrated good specificity and accuracy for the detection of real human serum samples. Above all, the blue SiNPs-based LFIA that we developed provides a rapid, highly accurate, and inexpensive on-site diagnosis of human brucellosis, and shows great promise in clinical diagnostics for other diseases.
Germplasm Screening of Green Manure Rapeseed through the Effects of Short-Term Decomposition on Soil Nutrients and Microorganisms
Authors: Wang Xiaodan , Ma Hua , Guan Chunyun , Guan Mei
Published: December 2021

The rapidly emerging fertilizer rapeseed used as green manure has wide applications for use. However, there have been few studies on its decomposition and effects on soil nutrients and microorganisms after its decay. In this study, 12 rapeseed lines to be screened were decomposed through a randomized block field design with two green-manure-specific varieties as the controls. The contents of nitrogen, phosphorus, and potassium from the plants, soil nutrients, and microbial changes after degradation were measured. There were substantial differences in the rates of decomposition and cumulative release of nutrients among the different lines after 30 days of rolling. The contents of phosphorus and potassium in the soil were 1.23–2.03 and 3.93–6.32 times those before decomposition, respectively. In addition, there was a significant difference in the relative content of soil microorganisms at the phylum level after the decomposition of different species of rapeseeds. Most of the top 20 bacterial groups significantly correlated with the characteristics of plant decomposition and soil nutrient content, including Proteobacteria, Actinomycetes, Armatimonadetes, Rokubacteria, and Planctomycetes. A principal component analysis showed that the soil microorganisms and nutrients are the leading factors that enable the evaluation of the decomposing characteristics of green manure rapeseed. Numbers 5 (purple leaf mustard) and 8 (Xiafang self-seeding) were more effective than two controls, which can be used as excellent types of germplasm to promote the breeding of green manure rapeseed.
Effects of Sex Class, a Combined Androgen and Estrogen Implant, and Pasture Supplementation on Growth and Carcass Performance and Meat Quality of Zebu-Type Grass-Fed Cattle
Authors: Huerta-Leidenz Nelson , Jerez-Timaure Nancy , Sarturi Jhones Onorino , Brashears Mindy M. , Miller Markus F. , Moya Alexis , Godoy Susmira
Published: December 2021

Forty-seven Zebu calves were used to determine the effects of class (bull or steer), supplementation (SUPPL, a poultry litter-based supplement or mineral supplementation), and implant (20 mg estradiol combined with 120 mg of trenbolone acetate or no implant) on growth and carcass performance and beef eating quality. The average daily gain (ADG) of implanted cattle significantly increased for steers, but not for bulls. The SUPPL treatment increased ADG by 8.63% from day 0 to end, and shortened in 73.3 d the time to reach 480 kg BW (p < 0.01). Compared to bulls, the steer carcasses exhibited more desirable maturity and finish scores, thicker back fat (p < 0.05), and yielded greater (p < 0.01) percentages of high-value boneless subprimals (HVBLS) (+1.64%) and total cuts (1.35%). The SUPPL bulls dressed 2.63 and 1.63% greater than non-supplemented bulls and SUPPL steers, respectively (p < 0.05). Meat sensory quality was subtly affected (p < 0.05) by sex class or supplementation. The implant did not affect (p > 0.05) shear force or sensory ratings. The supplementation improved key growth performance traits while it adversely affected tenderness-related sensory traits. The implant enhanced the rate of gain of steers only, without improving cut-out yields or inducing adverse effects on palatability traits in both steers and bulls.
Offshore Occurrence of a Migratory Bat, Pipistrellus nathusii, Depends on Seasonality and Weather Conditions
Authors: Lagerveld Sander , Jonge Poerink Bob , Geelhoed Steve C. V.
Published: December 2021

Bats regularly migrate over the North Sea, but information on the environmental conditions when this occurs is scarce. Detailed information is urgently needed on the conditions under which bats can be expected offshore, as the number of offshore windfarms that can cause fatalities amongst bats in the North Sea is increasing rapidly. We performed ultrasonic acoustic monitoring at multiple nearshore locations at sea between 2012 and 2016 for, in total, 480 monitoring nights. We modelled the offshore occurrence of Nathusius’ pipistrelle in autumn as a function of weather conditions, seasonality, and the lunar cycle using a generalized additive mixed model (GAMM). We investigated which covariates are important using backward selection based on a likelihood ratio test. Our model showed that important explanatory variables for the offshore occurrence of Nathusius’ pipistrelle are seasonality (night in year), wind speed, wind direction, and temperature. The species’ migration is strongest in early September, with east-northeasterly tailwinds, wind speeds < 5 m/s, and temperatures > 15 °C. Lunar cycle, cloud cover, atmospheric pressure, atmospheric pressure change, rain, and visibility were excluded during the model selection. These results provide valuable input to reduce bat fatalities in offshore wind farms by taking mitigation measures.
Canine Epithelial Thymic Tumors: Outcome in 28 Dogs Treated by Surgery
Authors: Martano Marina , Buracco Paolo , Morello Emanuela Maria
Published: December 2021

Thymoma is a tumor rarely reported in dogs and should be differentiated from mediastinal lymphoma. Clinical signs may have a late onset, and thymoma is often diagnosed when symptoms related to the space-occupying effect or paraneoplastic syndromes occur. CT and fine-needle aspirates or core biopsies are helpful in differential diagnosis, but flow cytometry may improve the pre-operative diagnostic ability. Concurrent paraneoplastic syndromes such as myasthenia gravis and hypercalcemia have been reported; however, their role as prognostic factors is not well determined. Surgical excision is the treatment of choice; adjuvant radiotherapy and/or chemotherapy may prolong survival in cases of incomplete excision or when a thymic carcinoma is diagnosed. Local recurrence and metastasis are infrequently reported; therefore, a long survival time is expected if the tumor is completely excised or if adjuvant therapy is undertaken. This article reports the authors’ experience with 28 dogs affected by 18 thymomas and 10 thymic carcinomas. The median overall survival in this series was 1173 days, and the median disease-free interval was 903 days. Dogs with thymic carcinoma had significantly shorter disease-free intervals and shorter, although not statistically significant, survival times. Dogs with Masaoka Stage III tumors had worse outcomes.
A Perspective on Li/S Battery Design: Modeling and Development Approaches
Authors: McCreary Chase , An Yuhui , Kim Sun Ung , Hwa Yoon
Published: December 2021

Lithium/sulfur (Li/S) cells that offer an ultrahigh theoretical specific energy of 2600 Wh/kg are considered one of the most promising next-generation rechargeable battery systems for the electrification of transportation. However, the commercialization of Li/S cells remains challenging, despite the recent advancements in materials development for sulfur electrodes and electrolytes, due to several critical issues such as the insufficient obtainable specific energy and relatively poor cyclability. This review aims to introduce electrode manufacturing and modeling methodologies and the current issues to be overcome. The obtainable specific energy values of Li/S pouch cells are calculated with respect to various parameters (e.g., sulfur mass loading, sulfur content, sulfur utilization, electrolyte-volume-to-sulfur-weight ratio, and electrode porosity) to demonstrate the design requirements for achieving a high specific energy of >300 Wh/kg. Finally, the prospects for rational modeling and manufacturing strategies are discussed, to establish a new design standard for Li/S batteries.
MicroRNA and Alternative mRNA Splicing Events in Cancer Drug Response/Resistance: Potent Therapeutic Targets
Authors: Marima Rahaba , Francies Flavia Zita , Hull Rodney , Molefi Thulo , Oyomno Meryl , Khanyile Richard , Mbatha Sikhumbuzo , Mabongo Mzubanzi , Owen Bates David , Dlamini Zodwa
Published: December 2021

Cancer is a multifaceted disease that involves several molecular mechanisms including changes in gene expression. Two important processes altered in cancer that lead to changes in gene expression include altered microRNA (miRNA) expression and aberrant splicing events. MiRNAs are short non-coding RNAs that play a central role in regulating RNA silencing and gene expression. Alternative splicing increases the diversity of the proteome by producing several different spliced mRNAs from a single gene for translation. MiRNA expression and alternative splicing events are rigorously regulated processes. Dysregulation of miRNA and splicing events promote carcinogenesis and drug resistance in cancers including breast, cervical, prostate, colorectal, ovarian and leukemia. Alternative splicing may change the target mRNA 3′UTR binding site. This alteration can affect the produced protein and may ultimately affect the drug affinity of target proteins, eventually leading to drug resistance. Drug resistance can be caused by intrinsic and extrinsic factors. The interplay between miRNA and alternative splicing is largely due to splicing resulting in altered 3′UTR targeted binding of miRNAs. This can result in the altered targeting of these isoforms and altered drug targets and drug resistance. Furthermore, the increasing prevalence of cancer drug resistance poses a substantial challenge in the management of the disease. Henceforth, molecular alterations have become highly attractive drug targets to reverse the aberrant effects of miRNAs and splicing events that promote malignancy and drug resistance. While the miRNA–mRNA splicing interplay in cancer drug resistance remains largely to be elucidated, this review focuses on miRNA and alternative mRNA splicing (AS) events in breast, cervical, prostate, colorectal and ovarian cancer, as well as leukemia, and the role these events play in drug resistance. MiRNA induced cancer drug resistance; alternative mRNA splicing (AS) in cancer drug resistance; the interplay between AS and miRNA in chemoresistance will be discussed. Despite this great potential, the interplay between aberrant splicing events and miRNA is understudied but holds great potential in deciphering miRNA-mediated drug resistance.
Prostaglandin F2 and EP2 Agonists Exert Different Effects on 3D 3T3-L1 Spheroids during Their Culture Phase
Authors: Ida Yosuke , Furuhashi Masato , Watanabe Megumi , Umetsu Araya , Hikage Fumihito , Ohguro Hiroshi
Published: December 2021

To elucidate the effects of switching a PGF2α agonist, bimatoprost acid (BIM-A), to an EP2 agonist (Omidenepag—OMD; butaprost—Buta) or reversing the switching on adipose tissue, two-dimensional (2D) and three-dimensional (3D) cultures of 3T3-L1 cells were analyzed by lipid staining and according to the mRNA expression of adipogenesis-related genes (Pparγ, Ap2, and Leptin), components of the extracellular matrix (ECM; collagen1 (Col1), Col4, Col6, and fibronectin (Fn)), and the sizes and stiffness of the 3D spheroids. Switching from BIM-A to EP2 agonists caused (1) suppression of lipid staining and downregulation of most adipogenesis-related genes, (2) smaller and stiffer 3D spheroids, and (3) upregulation of Col1 and Fn, downregulation of Col4 (2D), or up-regulation of all ECM genes (3D, BIM-A to OMD), as well as downregulation of Col6 (3D, BIM-A to Buta). In contrast, reversing the switching resulted in (1) an enhancement in lipid staining (2D) and a significant upregulation of adipogenesis-related genes (2D, 3D Buta to BIM-A), (2) larger and slightly stiffer 3D spheroids, and (3) upregulation of Col1 and Fn (2D). These collective findings indicate that the switching orders of BIM-A and EP2 agonists have a significant effect on lipid metabolism, ECM expression, and the physical stiffness of 3T3-L1 cells.
Intraoperative Rupture of an Intracranial, Extradural Hydatid Cyst: Case Report and Treatment Options
Authors: Cindea Cosmin-Nicodim , Saceleanu Vicentiu , Saceleanu Adriana
Published: December 2021

A 23-year-old woman was presented to the Emergency Unit with intracranial hypertension syndrome and blindness in her left eye which had started recently. A cranial native computed tomography scan and a magnetic resonance imaging (MRI) with contrast examinations revealed a giant intracranial cystic lesion, extending into the left frontal lobe, which was compressing the optic chiasm and eroding the internal plate of the left frontal bone. Surgical craniotomy was performed for evacuation and decompression, but during the craniotomy the cyst ruptured. After assessing the degree of erosion of the internal bone plate, we concluded that the primary origin of the cyst was intraosseous. With the dura mater being intact, abundant lavage with H2O2 was applied and the bone flap was replaced after rigorous bone scraping. Imaging control at six and twelve months identified no recurrence of the cyst. In the literature, hydatid cysts located in the skull bone are very rare and most of them rupture intraoperatively. Given their extremely low incidence in developed countries, any neurosurgeons’ experience with such pathology is limited and in some cases surgery cannot be delayed. In the case of intracerebral hydatid cysts, a neurosurgeon usually has only one shot at surgery, so simple and quick-to-access therapeutic guidelines must be developed in order to inform the choice of surgical technique. We conclude that the most successful surgical approach could be double concentric craniotomy. This surgical technique is used in intracerebral tumors, which also have an important bone invasion.
Melanoma Management during the COVID-19 Pandemic Emergency: A Literature Review and Single-Center Experience
Authors: Cariti Caterina , Merli Martina , Avallone Gianluca , Rubatto Marco , Marra Elena , Fava Paolo , Caliendo Virginia , Picciotto Franco , Gualdi Giulio , Stanganelli Ignazio , Fierro Maria Teresa , Ribero Simone , Quaglino Pietro
Published: December 2021

Background: The current COVID-19 pandemic has influenced the modus operandi of all fields of medicine, significantly impacting patients with oncological diseases and multiple comorbidities. Thus, in recent months, the establishment of melanoma management during the emergency has become a major area of interest. In addition to original articles, case reports and specific guidelines for the period have been developed. Purpose: This article aims to evaluate whether melanoma management has been changed by the outbreak of COVID-19, and if so, what the consequences are. We summarized the main issues concerning the screening of suspicious lesions, the diagnosis of primary melanoma, and the management of early-stage and advanced melanomas during the pandemic. Additionally, we report on the experience of our dermatological clinic in northern Italy. Methods: We performed a literature review evaluating articles on melanomas and COVID-19 published in the last two years on PubMed, as well as considering publications by major healthcare organizations. Concerning oncological practice in our center, we collected data on surgical and therapeutic procedures in patients with a melanoma performed during the first months of the pandemic. Conclusions: During the emergency period, the evaluation of suspicious skin lesions was ensured as much as possible. However, the reduced level of access to medical care led to a documented delay in the diagnosis of new melanomas. When detected, the management of early-stage and advanced melanomas was fully guaranteed, whereas the follow-up visits of disease-free patients have been postponed or replaced with a teleconsultation when possible.
EWSR1-WT1 Target Genes and Therapeutic Options Identified in a Novel DSRCT In Vitro Model
Authors: Bleijs Margit , Pleijte Corine , Engels Sem , Ringnalda Femke , Meyer-Wentrup Friederike , van de Wetering Marc , Clevers Hans
Published: December 2021

Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive soft tissue sarcoma with a lack of effective treatment options and a poor prognosis. DSRCT is characterized by a chromosomal translocation, resulting in the EWSR1-WT1 gene fusion. The molecular mechanisms driving DSRCT are poorly understood, and a paucity of preclinical models hampers DSRCT research. Here, we establish a novel primary patient-derived DSRCT in vitro model, recapitulating the original tumor. We find that EWSR1-WT1 expression affects cell shape and cell survival, and we identify downstream target genes of the EWSR1-WT1 fusion. Additionally, this preclinical in vitro model allows for medium-throughput drug screening. We discover sensitivity to several drugs, including compounds targeting RTKs. MERTK, which has been described as a therapeutic target for several malignancies, correlates with EWSR1-WT1 expression. Inhibition of MERTK with the small-molecule inhibitor UNC2025 results in reduced proliferation of DSRCT cells in vitro, suggesting MERTK as a therapeutic target in DSRCT. This study underscores the usefulness of preclinical in vitro models for studying molecular mechanisms and potential therapeutic options.
Overexpression of Neuroglobin Promotes Energy Metabolism and Autophagy Induction in Human Neuroblastoma SH-SY5Y Cells
Authors: Manganelli Valeria , Salvatori Illari , Costanzo Michele , Capozzi Antonella , Caissutti Daniela , Caterino Marianna , Valle Cristiana , Ferri Alberto , Sorice Maurizio , Ruoppolo Margherita , Garofalo Tina , Misasi Roberta
Published: December 2021

Neuroglobin (NGB) is an O2-binding globin mainly expressed in the central and peripheral nervous systems and cerebrospinal fluid. Previously, it was demonstrated that NGB overexpression protects cells from hypoxia-induced death. To investigate processes promoted by NGB overexpression, we used a cellular model of neuroblastoma stably overexpressing an NGB-FLAG construct. We used a proteomic approach to identify the specific profile following NGB overexpression. To evaluate the role of NGB overexpression in increasing energetic metabolism, we measured oxygen consumption rate (OCR) and the extracellular acidification rate through Seahorse XF technology. The effect on autophagy induction was evaluated by analyzing SQSTM1/p62 and LC3-II expression. Proteomic analysis revealed several differentially regulated proteins, involved in oxidative phosphorylation and integral mitochondrial proteins linked to energy metabolism. The analysis of mitochondrial metabolism demonstrated that NGB overexpression increases mitochondrial ATP production. Indeed, NGB overexpression enhances bioenergetic metabolism, increasing OCR and oxygen consumption. Analysis of autophagy induction revealed an increase of LC3-II together with a significant decrease of SQSTM1/p62, and NGB-LC3-II association during autophagosome formation. These results highlight the active participation of NGB in several cellular processes that can be upregulated in response to NGB overexpression, playing a role in the adaptive response to stress in neuroblastoma cells.
A New Player in Jasmonate-Mediated Stomatal Closure: The Arabidopsis thaliana Copper Amine Oxidase β
Authors: Fraudentali Ilaria , Pedalino Chiara , Tavladoraki Paraskevi , Angelini Riccardo , Cona Alessandra
Published: December 2021

Plant defence responses to adverse environmental conditions include different stress signalling, allowing plant acclimation and survival. Among these responses one of the most common, immediate, and effective is the modulation of the stomatal aperture, which integrates different transduction pathways involving hydrogen peroxide (H2O2), calcium (Ca2+), nitric oxide (NO), phytohormones and other signalling components. The Arabidopsis thaliana copper amine oxidases β (AtCuAOβ) encodes an apoplastic CuAO expressed in guard cells and root protoxylem tissues which oxidizes polyamines to aminoaldehydes with the production of H2O2 and ammonia. Here, its role in stomatal closure, signalled by the wound-associated phytohormone methyl-jasmonate (MeJA) was explored by pharmacological and genetic approaches. Obtained data show that AtCuAOβ tissue-specific expression is induced by MeJA, especially in stomata guard cells. Interestingly, two Atcuaoβ T-DNA insertional mutants are unresponsive to this hormone, showing a compromised MeJA-mediated stomatal closure compared to the wild-type (WT) plants. Coherently, Atcuaoβ mutants also show compromised H2O2-production in guard cells upon MeJA treatment. Furthermore, the H2O2 scavenger N,N1-dimethylthiourea (DMTU) and the CuAO-specific inhibitor 2-bromoethylamine (2-BrEtA) both reversed the MeJA-induced stomatal closure and the H2O2 production in WT plants. Our data suggest that AtCuAOβ is involved in the H2O2 production implicated in MeJA-induced stomatal closure.
Molecular Basis of Accelerated Aging with Immune Dysfunction-Mediated Inflammation (Inflamm-Aging) in Patients with Systemic Sclerosis
Authors: Shen Chieh-Yu , Lu Cheng-Hsun , Wu Cheng-Han , Li Ko-Jen , Kuo Yu-Min , Hsieh Song-Chou , Yu Chia-Li
Published: December 2021

Systemic sclerosis (SSc) is a chronic connective tissue disorder characterized by immune dysregulation, chronic inflammation, vascular endothelial cell dysfunction, and progressive tissue fibrosis of the skin and internal organs. Moreover, increased cancer incidence and accelerated aging are also found. The increased cancer incidence is believed to be a result of chromosome instability. Accelerated cellular senescence has been confirmed by the shortening of telomere length due to increased DNA breakage, abnormal DNA repair response, and telomerase deficiency mediated by enhanced oxidative/nitrative stresses. The immune dysfunctions of SSc patients are manifested by excessive production of proinflammatory cytokines IL-1, IL-6, IL-17, IFN-α, and TNF-α, which can elicit potent tissue inflammation followed by tissue fibrosis. Furthermore, a number of autoantibodies including anti-topoisomerase 1 (anti-TOPO-1), anti-centromere (ACA or anti-CENP-B), anti-RNA polymerase enzyme (anti-RNAP III), anti-ribonuclear proteins (anti-U1, U2, and U11/U12 RNP), anti-nucleolar antigens (anti-Th/T0, anti-NOR90, anti-Ku, anti-RuvBL1/2, and anti-PM/Scl), and anti-telomere-associated proteins were also found. Based on these data, inflamm-aging caused by immune dysfunction-mediated inflammation exists in patients with SSc. Hence, increased cellular senescence is elicited by the interactions among excessive oxidative stress, pro-inflammatory cytokines, and autoantibodies. In the present review, we will discuss in detail the molecular basis of chromosome instability, increased oxidative stress, and functional adaptation by deranged immunome, which are related to inflamm-aging in patients with SSc.
What Are the Psycho-Social and Information Needs of Adolescents and Young Adults Cancer Care Consumers with Intellectual Disability? A Systematic Review of Evidence with Recommendations for Future Research and Practice
Authors: Ní Shé Éidín , McDonald Fiona E. J. , Mimmo Laurel , Ross Xiomara Skrabal , Newman Bronwyn , Patterson Pandora , Harrison Reema
Published: December 2021

People with intellectual disability have unmet health needs and experience health inequalities. There is limited literature regarding cancer care for children, adolescents, and young adults (AYA) with intellectual disability despite rising cancer incidence rates in this population. This systematic review aimed to identify the psycho-social and information support needs of AYA cancer care consumers with intellectual disability to generate recommendations for future research and cancer care service delivery enhancement. We searched eight databases yielding 798 articles. Following abstract and full-text review, we identified 12 articles meeting our inclusion criteria. Our three themes related to communication and accessible information; supports and system navigation, cancer service provider training, and reasonable adjustments. There was a lack of user-friendly, accessible information about cancer and screening programs available. Both paid and family carers are critical in accessing cancer supports, services, and screening programs for AYA with intellectual disability. Ongoing training should be provided to healthcare professionals regarding the importance of care screening for AYAs with intellectual disability. This review recommends that AYA with intellectual disability and their family carers be involved in developing tailored cancer services. This should focus on enabling inclusive screening programs, accessible consent, and challenging the enduring paternalism of support services via training and appropriate communication tools.
Electrical Properties in Ta2NiSe5 Film and van der Waals Heterojunction
Authors: Fukai Masaya , Urakami Noriyuki , Hashimoto Yoshio
Published: December 2021

Ternary Ta2NiSe5 is a novel electronic material having the property of an excitonic insulator at room temperature. The electrical properties of Ta2NiSe5 have not been elucidated in detail. We discuss the electronic properties in Ta2NiSe5 films and the formation of heterojunctions. Hall effect measurements showed p-type conductivity. The activation energies estimated from the temperature dependence of the carrier concentration were seen to be 0.17 eV and 0.12 eV, at approximately 300 and 400 K, respectively. It was observed that carrier generation behavior changes at the critical temperature of the excitonic insulator state (328 K). The temperature dependence of the Hall mobility below the critical temperature nearly follows the bell-shaped curves for conventional semiconductor materials. A MoS2/Ta2NiSe5 van der Waals heterojunction was fabricated using the transfer method. Rectification characteristics, which depend on the gate bias voltage, were obtained. The barrier height at the MoS2/Ta2NiSe5 heterointerface and the on/off ratio could be modulated by applying a gate bias voltage, suggesting that the carrier transport was exhibited in band-to-band flow. Our demonstration suggests that the knowledge of Ta2NiSe5 increased as an electronic material, and diode performance was successfully achieved for the electronic device applications.
Data Shepherding in Nanotechnology: An Antimicrobial Functionality Data Capture Template
Authors: Furxhi Irini , Varesano Alessio , Salman Hesham , Mirzaei Mahsa , Battistello Vittoria , Tomasoni Ivonne Tonani , Blosi Magda
Published: December 2021

In this paper, we exhibit how to construct a template for capturing antimicrobial capacity data of nanomaterials or nanoenabled products. The template promotes the principles of making data scientifically findable, accessible, interoperable and reusable (FAIR), encouraging scientists to reuse it. The template construction roadmap entails the following steps: (1) recognize appropriate stakeholders, (2) allocate surveys to collect a general explanation of the data that will be created, (3) comprehend each stakeholder’s requirements, (4) cooperating and using straightforward communication with the participants for the selection of the minimum data requirement reporting and (5) template layout and ontological annotation. We provide an annotated template for capturing antimicrobial data, increasing their interoperability while populating it with real measurements as an example. By applying the roadmap or by utilizing the template portrayed herein, in the case of a safe-by-design nanoproject (Anticipating Safety Issues at the Design of Nano Product Development (ASINA)), data creators of antimicrobial assessments can store the data using the FAIR approach. Furthermore, data shepherds and scientists can skip the lengthy template generation process and speed up the community’s progress on the FAIR route.
Guided Insertion of Temporary Anchorage Device in Form of Orthodontic Titanium Miniscrews with Customized 3D Templates—A Systematic Review with Meta-Analysis of Clinical Studies
Authors: Jedliński Maciej , Janiszewska-Olszowska Joanna , Mazur Marta , Ottolenghi Livia , Grocholewicz Katarzyna , Galluccio Gabriella
Published: December 2021

(1) Background: Miniscrew insertion, using a surgical guide, aims to avoid possible adverse effects or complications. With the higher availability of both 3D imaging and printing, 3D surgical guides have been used more frequently in orthodontics. The aim of the present systematic review was to find scientific clinical evidence concerning the precision of the 3D guided insertion of miniscrews for temporary orthodontic anchorage. (2) Methods: Literature searches were performed in the following five search engines: Pubmed (Medline), Pubmed Central, Scopus, Web of Science and Embase on 10 September 2021 (articles from 1950 to 10 September 2021). A meta-analysis was performed using the random-effect model, with Standardized Mean Differences (SMD) and 95% confidence intervals (95% CI) calculated as effect estimates. The heterogeneity was assessed quantitatively. (3) Results: The search strategy identified 671 potential articles. After the removal of duplicates, 530 articles were analyzed. Subsequently, 487 papers were excluded, because they were not associated with the subject of the study. Of the remaining 43 papers, 34 were excluded because they did not meet the methodological criteria. Finally, only nine papers were subjected to a qualitative analysis. (4) Conclusions: The current literature concerning guided miniscrew insertion reveals, for the most part, a low methodological level. High-quality clinical trials are in the minority. The use of surgical guides increases insertion accuracy, stability and reduces the failure rate of orthodontic miniscrews. Tooth-borne insertion guides supported on the edges of the teeth ensure a higher insertion precision compared to mucosa-borne ones. The study protocol was registered in PROSPERO under the number CRD42021267248.
Directed Surface Plasmon Resonance for Hot Carrier Applications
Authors: Forcherio Gregory T. , Boltersdorf Jonathan
Published: December 2021

The Special Issue, entitled Directed Surface Plasmon Resonance for Hot Carrier Applications, is a collection of four original articles centered around harnessing energetically “hot” carriers in tailored plasmonic materials for emergent applications in energy harvesting and sensing [...]
Efficient Proximal Gradient Algorithms for Joint Graphical Lasso
Authors: Chen Jie , Shimmura Ryosuke , Suzuki Joe
Published: December 2021

We consider learning as an undirected graphical model from sparse data. While several efficient algorithms have been proposed for graphical lasso (GL), the alternating direction method of multipliers (ADMM) is the main approach taken concerning joint graphical lasso (JGL). We propose proximal gradient procedures with and without a backtracking option for the JGL. These procedures are first-order methods and relatively simple, and the subproblems are solved efficiently in closed form. We further show the boundedness for the solution of the JGL problem and the iterates in the algorithms. The numerical results indicate that the proposed algorithms can achieve high accuracy and precision, and their efficiency is competitive with state-of-the-art algorithms.
Simple Equations Method and Non-Linear Differential Equations with Non-Polynomial Non-Linearity
Authors: Vitanov Nikolay K. , Dimitrova Zlatinka I.
Published: December 2021

We discuss the application of the Simple Equations Method (SEsM) for obtaining exact solutions of non-linear differential equations to several cases of equations containing non-polynomial non-linearity. The main idea of the study is to use an appropriate transformation at Step (1.) of SEsM. This transformation has to convert the non-polynomial non- linearity to polynomial non-linearity. Then, an appropriate solution is constructed. This solution is a composite function of solutions of more simple equations. The application of the solution reduces the differential equation to a system of non-linear algebraic equations. We list 10 possible appropriate transformations. Two examples for the application of the methodology are presented. In the first example, we obtain kink and anti- kink solutions of the solved equation. The second example illustrates another point of the study. The point is as follows. In some cases, the simple equations used in SEsM do not have solutions expressed by elementary functions or by the frequently used special functions. In such cases, we can use a special function, which is the solution of an appropriate ordinary differential equation, containing polynomial non-linearity. Specific cases of the use of this function are presented in the second example.
A Review on the Challenges of Using Zeolite 13X as Heat Storage Systems for the Residential Sector
Authors: Banaei Amirhossein , Zanj Amir
Published: December 2021

In recent years, several attempts have been made to promote renewable energy in the residential sector to help reducing its CO2 emissions. Among existing approaches utilizing substances capable of directly storing and transporting thermal energy has recently become a point of interest. Zeolite 13X with exceptional capacity to safely store thermal energy for long periods and release heat due to its unique molecular structure is known to be one of the best options serving this purpose. However, the application of this ceramic as a heat storage material in the residential sector is associated with significant challenges dictated by the limitations of the sector, such as space restrictions and affordability. The current review attempts to explore the extent of these challenges, mainly related to design and efficiency from different perspectives. The main aim here is to provide a clear vision for a better understanding of the state of the art of this technology and to help to identify possible solutions fostering the adaptation of this technology to the residential sector.
Traffic Intersection Lane Control Using Radio Frequency Identification and 5G Communication
Authors: Paszkiewicz Andrzej , Pawłowicz Bartosz , Trybus Bartosz , Salach Mateusz
Published: December 2021

This article deals with automated urban traffic management, and proposes a new comprehensive infrastructure solution for dynamic traffic direction switching at intersection lines. It was assumed that the currently used solutions based on video monitoring are unreliable. Therefore, the Radio Frequency IDentification (RFID) technique was introduced, in which vehicles are counted and, if necessary, identified in order to estimate the flows on individual lanes. The data is acquired in real time using fifth-generation wireless communications (5G). The Pots and Ising models derived from the theory of statistical physics were used in a novel way to determine the state of direction traffic lights. The models were verified by simulations using data collected from real traffic observations. The results were presented for two exemplary intersections.
Grid-Scale Battery Energy Storage Operation in Australian Electricity Spot and Contingency Reserve Markets
Authors: Bayborodina Ekaterina , Negnevitsky Michael , Franklin Evan , Washusen Alison
Published: December 2021

Conventional fossil-fuel-based power systems are undergoing rapid transformation via the replacement of coal-fired generation with wind and solar farms. The stochastic and intermittent nature of such renewable sources demands alternative dispatchable technology capable of meeting system stability and reliability needs. Battery energy storage can play a crucial role in enabling the high uptake of wind and solar generation. However, battery life is very sensitive to the way battery energy storage systems (BESS) are operated. In this paper, we propose a framework to analyse battery operation in the Australian National Electricity Market (NEM) electricity spot and contingency reserve markets. We investigate battery operation in different states of Australia under various operating strategies. By considering battery degradation costs within the operating strategy, BESS can generate revenue from the energy market without significantly compromising battery life. Participating in contingency markets, batteries can substantially increase their revenue with almost no impact on battery health. Finally, when battery systems are introduced into highly volatile markets (such as South Australia) more aggressive cycling of batteries leads to accelerated battery aging, which may be justified by increased revenue. The findings also suggest that with falling replacement costs, the operation of battery energy systems can be adjusted, increasing immediate revenues and moving the battery end-of-life conditions closer.
Climate Risk with Particular Emphasis on the Relationship with Credit-Risk Assessment: What We Learn from Poland
Authors: Nehrebecka Natalia
Published: December 2021

This research seeks to identify non-financial enterprises exposed to the climate risk relating to transition risks and at the same time use of bank loans, as well as to conduct stress tests to take account of the financial risk related to climate change. The workflow through which to determine the ability of the banking sector to assess the potential impact of climate risk entails parts based around economic sector and company level. The procedure based on the sectoral level identifies vulnerable economic sectors (in the Sectoral Module), while the procedure based on company level (the Company Module) refers to scenarios presented in stress tests to estimate the probability of default under stressful conditions related to the introduction of a direct carbon tax. The introduction of the average direct carbon tax (EUR 75/tCO2) in fact results in increased expenditure and reduced sales revenues among enterprises from sectors with a high CO2 impact, with the result being a decrease in the profitability of enterprises, along with a simultaneously higher level of debt; an increase in the probability of default (PD) from 3.6%, at the end of 2020 in the baseline macroeconomic scenario, to between 6.31% and 10.12%; and increased commercial bank capital requirements. Financial institutions should thus use PD under stressful conditions relating to climate risk as suggestions to downgrade under the expert module.
Accessible Modeling of the German Energy Transition: An Open, Compact, and Validated Model
Authors: Barbosa Julia , Ripp Christopher , Steinke Florian
Published: December 2021

We present an easily accessible model for dispatch and expansion planning of the German multi-modal energy system from today until 2050. The model can be used with low efforts while comparing favorably with historic data and other studies of future developments. More specifically, the model is based on a linear programming partial equilibrium framework and uses a compact set of technologies to ease the comprehension for new modelers. It contains all equations and parameters needed, with the data sources and model assumptions documented in detail. All code and data are openly accessible and usable. The model can reproduce today’s energy mix and its CO2 emissions with deviations below 10%. The generated energy transition path, for an 80% CO2 reduction scenario until 2050, is consistent with leading studies on this topic. Our work thus summarizes the key insights of previous works and can serve as a validated and ready-to-use platform for other modelers to examine additional hypotheses.
Seeking the Pressure Points: Catalysing Low Carbon Changes from the Middle-Out in Offices and Schools
Authors: Willan Catherine , Janda Kathryn B. , Kenington David
Published: December 2021

Non-domestic buildings are frequently characterised as resistant to top-down low-carbon and energy-efficiency policy. Complex relationships amongst building stakeholders are often blamed. “Middle actors”—professionals situated between policymakers and building users—can use their agency and capacity to facilitate energy and carbon decision-making from the “middle-out”. We use semi-structured interviews with expert middle actors working with schools and commercial offices, firstly, to explore their experience of energy and low-carbon decision-making in buildings and, secondly, to reflect on the evolution of middle actors’ role within it. Our exploratory findings suggest that a situated sensitivity to organisational “pressure points” can enhance middle actors’ agency and capacity to catalyse change. We find shifts in the ecology of the “middle”, as the UK’s Net Zero and Environmental, Social and Governance (ESG) agendas pull in new middle actors (such as the financial community) and issues (such as wellbeing and social value) to non-domestic buildings. These issues may work in reinforcing ways with organisational pressure points. Policy should capitalise on this impetus by looking beyond the physicality of individual buildings and engage with middle actors at a systemic level. This could create greater synergies with organisational concerns and strategies of building stakeholders.
Evaluating the Impact of Energy Efficiency Building Codes for Residential Buildings in the GCC
Authors: Elnabawi Mohamed H.
Published: December 2021

In arid climates, almost half of the urban peak load of energy demand is used to supply cooling and air-conditioning in the summertime. The pressure placed on energy resources to satisfy inhabitants’ indoor comfort requirements is mounting due to accelerated urbanisation rates in developing countries and has led countries such as those in the GCC (Gulf Cooperation Council) to establish sustainable building codes to enhance their environmental performance. Using the extensive parametric energy simulations provided by DesignBuilder, this study addresses the potential of applying different GCC energy efficiency measures to reduce annual energy consumption and carbon emissions in a typical residential dwelling in the Kingdom of Bahrain. To do so, first, a base case validation simulation model was generated, followed by four design scenarios addressing the minimum requirements for Bahrain’s Energy Conservation Code, Abu Dhabi’s ESTIDAMA 1, Saudi Arabia’s code, and Kuwait’s building code. Then, a feasibility study was conducted using the simple payback period (SPP) and lifecycle cost (LCC) analysis. Overall energy and carbon emission (CO2) reduction showed the potential for building sustainable codes to improve building environmental performance throughout the year. In terms of energy performance and CO2 reduction, Abu Dhabi’s ESTIDAMA 1 code recorded the best energy savings at a 24.4% and a 26.3% reduction in carbon emissions, followed by the Saudi code with a 14.6% annual energy savings and 12.3% less carbon emissions. Regarding the economic analysis, although the SPP indicates the Bahraini code offered payback in just under two years for subsidised energy and half a year for unsubsidised, the LCC analysis suggests that applying Abu Dhabi’s ESTIDAMA 1 code was the most feasible, followed by the Saudi building code. Consequently, the study suggests a comprehensive evaluation of the relationship between the sustainable building codes and their economic feasibility in order to enhance and promote the wide application in the GCC based on the code’s capabilities and their benefits for residential households and the overall economy.
Shapes and Rise Velocities of Single Bubbles in a Confined Annular Channel: Experiments and Numerical Simulations
Authors: Cioncolini Andrea , Magnini Mirco
Published: December 2021

Shapes and rise velocities of single air bubbles rising through stagnant water confined inside an annular channel were investigated by means of experiments and numerical simulations. Fast video imaging and image processing were used for the experiments, whilst the numerical simulations were carried out using the volume of fluid method and the open-source package OpenFOAM. The confinement of the annular channel did not affect the qualitative behavior of the bubbles, which exhibited a wobbling rise dynamic similar to that observed in bubbles rising through unconfined liquids. The effect of the confinement on the shape and rise velocity was evident; the bubbles were less deformed and rose slower in comparison with bubbles rising through unconfined liquids. The present data and numerical simulations, as well as the data collected from the literature for use here, indicate that the size, shape, and rise velocity of single bubbles are closely linked together, and prediction methods that fail to recognize this perform poorly. This study and the limited evidence documented in the literature indicate that the confinement effects observed in non-circular channels of complex shape are more complicated than those observed with circular tubes, and much less well understood.
Effect of Welsh Onion on Taste Components and Sensory Characteristics of Porcine Bone Soup
Authors: Liang Li , Zhou Chenchen , Zhang Yuyu , Sun Baoguo
Published: December 2021

To investigate the effect of welsh onion on taste components and sensory characteristics in porcine bone soup, the stewing condition was as follows: the material–liquid ratio (m/V) was 1:1, the stewing time was 5.0 h, and the ratio of welsh onion was 2.5%. Then, the content of taste components was measured. The content of free amino acids in porcine bone soup with welsh onion (PWS) was higher than the sum of welsh onion soup (WS) and porcine bone soup (PS); particularly, the umami amino acids increased by 35.73% compared with PS. Significant increases in four organic acids (lactic acid, pyroglutamic acid, citric acid and ascorbic acid), two 5′-nucleotides (5′-AMP and 5′-GMP) and three mineral elements (K, Ca and Mg) were observed in PWS. Compared with PS, the equivalent umami concentration (EUC) value was increased from 79.09 to 106.47 mg MSG/100 g in PWS, which was due to the high content of umami amino acids and the synergistic effect with 5′-nucleotides. The results of the sensory analysis indicated a certain enhancement of umami taste in PWS, and the sweet and salty tastes were also increased with the addition of welsh onion. The correlation analysis was consistent with the variation of the components tested above.