bluuebunny/crossref_metadata_2025 huggingface dataset:
SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome
Authors: Janer Alexandre , Prudent Julien , Paupe Vincent , Fahiminiya Somayyeh , Majewski Jacek , Sgarioto Nicolas , Des Rosiers Christine , Forest Anik , Lin Zhen‐Yuan , Gingras Anne‐Claude , Mitchell Grant , McBride Heidi M , Shoubridge Eric A
Published: July 2016

Mitochondria form a dynamic network that responds to physiological signals and metabolic stresses by altering the balance between fusion and fission. Mitochondrial fusion is orchestrated by conserved GTPases MFN1/2 and OPA1, a process coordinated in yeast by Ugo1, a mitochondrial metabolite carrier family protein. We uncovered a homozygous missense mutation in SLC25A46, the mammalian orthologue of Ugo1, in a subject with Leigh syndrome. SLC25A46 is an integral outer membrane protein that interacts with MFN2, OPA1, and the mitochondrial contact site and cristae organizing system (MICOS) complex. The subject mutation destabilizes the protein, leading to mitochondrial hyperfusion, alterations in endoplasmic reticulum (ER) morphology, impaired cellular respiration, and premature cellular senescence. The MICOS complex is disrupted in subject fibroblasts, resulting in strikingly abnormal mitochondrial architecture, with markedly shortened cristae. SLC25A46 also interacts with the ER membrane protein complex EMC, and phospholipid composition is altered in subject mitochondria. These results show that SLC25A46 plays a role in a mitochondrial/ER pathway that facilitates lipid transfer, and link altered mitochondrial dynamics to early‐onset neurodegenerative disease and cell fate decisions.
Early-life glucocorticoids programme behaviour and metabolism in adulthood in zebrafish
Authors: Wilson K S , Tucker C S , Al-Dujaili E A S , Holmes M C , Hadoke P W F , Kenyon C J , Denvir M A
Published: July 2016

Glucocorticoids (GCs)in uteroinfluence embryonic development with consequent programmed effects on adult physiology and pathophysiology and altered susceptibility to cardiovascular disease. However, in viviparous species, studies of these processes are compromised by secondary maternal influences. The zebrafish, being fertilised externally, avoids this problem and has been used here to investigate the effects of transient alterations in GC activity during early development. Embryonic fish were treated either with dexamethasone (a synthetic GC), an antisense GC receptor (GR) morpholino (GR Mo), or hypoxia for the first 120h post fertilisation (hpf); responses were measured during embryonic treatment or later, post treatment, in adults. All treatments reduced cortisol levels in embryonic fish to similar levels. However, morpholino- and hypoxia-treated embryos showed delayed physical development (slower hatching and straightening of head–trunk angle, shorter body length), less locomotor activity, reduced tactile responses and anxiogenic activity. In contrast, dexamethasone-treated embryos showed advanced development and thigmotaxis but no change in locomotor activity or tactile responses. Gene expression changes were consistent with increased (dexamethasone) and decreased (hypoxia, GR Mo) GC activity. In adults, stressed cortisol values were increased with dexamethasone and decreased by GR Mo and hypoxia pre-treatments. Other responses were similarly differentially affected. In three separate tests of behaviour, dexamethasone-programmed fish appeared ‘bolder’ than matched controls, whereas Mo and hypoxia pre-treated fish were unaffected or more reserved. Similarly, the dexamethasone group but not the Mo or hypoxia groups were heavier, longer and had a greater girth than controls. Hyperglycaemia and expression of GC responsive gene (pepck) were also increased in the dexamethasone group. We conclude that GC activity controls many aspects of early-life growth and development in the zebrafish and that, like other species, manipulating GC status pharmacologically, physiologically or genetically in early life leads to programmable metabolic and behavioural traits in adulthood.
Case Report of Methemoglobinemia in a Toddler Secondary to Topical Dapsone Exposure
Authors: Graff Danielle M. , Bosse George M. , Sullivan Janice
Published: July 2016

Aczone gel 5% contains dapsone and is a commonly used topical dermatologic therapy for acne in adolescents and adults. We describe the first reported pediatric case of a previously healthy girl presenting with acute onset of methemoglobinemia after exposure to her sibling’s Aczone gel. The patient was successfully treated with methylene blue initially and subsequently needed an additional dose for rebound methemoglobinemia. This case demonstrates the complications of systemic absorption of dapsone in the pediatric population resulting in clinically significant methemoglobinemia from a single topical application.
Fetal Alcohol Growth Restriction and Cognitive Impairment
Authors: Carter R. Colin , Jacobson Joseph L. , Molteno Christopher D. , Dodge Neil C. , Meintjes Ernesta M. , Jacobson Sandra W.
Published: July 2016

BACKGROUND:

Although both fetal and long-term growth restriction are well documented in fetal alcohol spectrum disorders, effects on pattern of growth trajectory have not been characterized. Furthermore, the degree to which growth trajectories are related to fetal alcohol-related neurocognitive deficits is unknown.

METHODS:

Ninety-three heavy drinking pregnant women and 64 controls were recruited at initiation of prenatal care in Cape Town, South Africa. Small for gestational age (SGA) was defined as birth weight <10th percentile. Length/height, weight, and head circumference were measured at 6.5 and 12 months and 5, 9, and 13 years. Four growth trajectories were identified: SGA with long-term postnatal growth restriction (length/height-for-age <10th percentile through 13 years); SGA with catch-up growth; no SGA or postnatal growth restriction; and late-onset postnatal stunting. IQ was assessed at 5 and 10 years, and learning, memory, and executive function at 10 years.

RESULTS:

Children born SGA with postnatal growth restriction were most heavily exposed. Exposure was intermediate for those born SGA with catch-up growth and lowest for those without prenatal or postnatal growth restriction. Effects on neurocognition were strongest in children with both prenatal and long-term growth restriction, more moderate in those with fetal growth restriction and postnatal catch-up, and weakest in those without growth restriction.

CONCLUSIONS:

These findings validate the use of growth restriction in the diagnosis of fetal alcohol spectrum disorders and identify growth trajectory as a biomarker of which heavily exposed children are at greatest risk for cognitive developmental deficits.
Fractional Flow Reserve Measurement by Computed Tomography: An Alternative to the Stress Test
Authors: Lee Ji Hyun ,   Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, New York, NY, USA,   Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, New York, NY, USA,   Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, New York, NY, USA, Rizvi Asim ,   Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, New York, NY, USA, Lin Fay Y ,   Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, New York, NY, USA,   Departments of Radiology and Medicine, Weill Cornell Medical College, New York, NY, USA, Min James K ,   Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, New York, NY, USA,   Departments of Radiology and Medicine, Weill Cornell Medical College, New York, NY, USA, Hartaigh Bríain ó , Han Donghee
Published: July 2016

Recent advances in computed tomographic technology have contributed towards improving coronary computed tomography angiography (CCTA) in determining the severity of coronary artery disease anatomically. Although the viability of CCTA has most often been confined to anatomical assessment, recent development has enabled evaluation of the haemodynamic significance of coronary artery disease. In light of this, CCTA-derived fractional flow reserve (FFRCT), a novel imaging modality, now permits the physiological assessment of coronary artery disease. To date, several studies have documented the diagnostic performance of FFRCT, and more trials are being performed that will further substantiate this technique. The present paper provides an overview and discussion of the available evidence for FFRCT in the clinical setting as well as potential future directions of FFRCT.
La publicidad alimentaria como factor de cambio en las prácticas alimentarias en la ciudad de Medellín, 1950-1970
Authors: Rodríguez Cossio Luz Aidé
Published: July 2016

La finalidad de este artículo fue estudiar la forma en que la industria alimentaria posicionó sus productos por medio de la publicidad en las décadas del 50 y 60 del siglo XX en Medellín. Para ello, se tratarán algunos temas o argumentos que los anuncios utilizaron para este propósito. La recopilación de la publicidad sobre alimentos industriales en el periódico El Colombiano y la revista Cromos permitió constituir el material con el que se realizó el análisis de la manera en que las fábricas alimenticias promocionaron la nueva oferta de comestibles. La continua reiteración de los argumentos con relación a la salud fue la razón para que éste hiciera parte del análisis. El otro argumento fue el de la comodidad o servicio, en el que la rapidez y facilidad que se incorporaba con estos artículos en la preparación de la comida, fue importante para las amas de casa.
Los viajes de J. G. Eberhard por la Amazonia Colombiana
Authors: Cabrera Gabriel
Published: July 2016

Esta es la transcripción comentada de un viajero no citado en la literatura sobre la región.
Intelectuales, política y religión en Colombia en el siglo XIX: José Manuel Groot y los escritores católicos
Authors: Jiménez Ángel Andrés
Published: July 2016

Este artículo analiza los factores objetivos y subjetivos, los aspectos políticos y sociales que caracterizaron, inspiraron y justificaron la producción periodística, literaria e historiográfica de los escritores católicos en la segunda mitad del siglo XIX en Colombia, centrándose en José Manuel Groot. Primero, se presenta un bosquejo de la configuración del catolicismo colombiano durante la hegemonía liberal para luego aludir a los canales y espacios a través de los cuales estos intelectuales difundieron sus trabajos y fortalecieron los vínculos sociales entre ellos. En tercer lugar, se abordarán las funciones particulares que estos escritores asumieron como propias así como sus enfrentamientos con la jerarquía eclesiástica. Por último, se plantean algunos puntos de reflexión con respecto a la autonomía del intelectual decimonónico, su autopercepción y a la importancia de las trayectorias individuales y colectivas en la historia de los intelectuales en Colombia.
El debate marxista sobre los modos de producción coloniales latinoamericanos en el seno de la intelectualidad argentina (1890-1973)
Authors: Bosch Alessio Constanza Daniela
Published: July 2016

La determinación de la índole de la economía colonial ha constituido una preocupación que ha excedido ampliamente el campo del materialismo histórico. Sin embargo, ha sido en el ámbito del marxismo en donde el debate ha acopiado la mayor parte de las intervenciones, tomando como punto de partida el concepto de “modo de producción” o “formación socio-económica” y haciendo hincapié en la pregunta acerca de los orígenes del capitalismo y de las raíces del atraso de las colonias americanas. Mientras algunos intelectuales afirmaron su carácter predominantemente feudal, otros optaron, en cambio, por definirlo como “capitalismo colonial”. El presente trabajo se propone, por tanto, analizar desde una perspectiva crítica de la Historia Intelectual, las tesis materialistas acerca de los modos de producción coloniales en América Latina, a fines de examinar las visiones en pugna de la historiografía marxista local acerca de los orígenes y el desarrollo del capitalismo en  la actual Argentina.
ANTHROPOLOGICAL INTENTION OF PHILOSOPHIZING OF RENE DESCARTES AND ITS MANIFESTATION IN THE TEXT «THE RULES»
Authors: Malivskyi Anatolii
Published: July 2016

Purpose. Based on the understanding of The New Time philosophy as a response to the challenges of the era in relation to the construction of an objective picture of the world and the self-creation of man, to analyze the main options for evaluating the ambivalence of the basic intention of the philosophy of Descartes in the research literature and to clarify the nature of ambiguity. To justify the dominant nature of anthropological intention in the text of the «Rules for Guiding the Mind in Searching for the Truth». Novelty. The nature of the ambivalence of the basic intention of the text of the "Rules" is clarified as a form of two basic existences, opposite to the New Time, namely the query on the objectivity of scientific knowledge and inquiry in anthropology as a cornerstone of philosophy. The author of the article proves the domination of anthropological component of the text «The Rules» in front of scientific knowledge. Conclusions. The main manifestations of ambivalence of basic directivity of philosophizing of Rene Descartes to construction of an objective picture of the world and self-creation of person were described. The determining influence on the process of the establishment of basic intention of the specificity of the experience of mathematical knowledge and Plato’s and Aristotle’s tradition of philosophizing for the first, and of personal tradition of Christianity in the second place was emphasized. In the reference to the text «The Rules» of Descartes the ambiguity of the basic direction was argued, the nature and domination of the anthropological intention were justified.
ANTHROPOLOGICAL DESCARTES’ RATIONALISM AND IT'S HUSSERL’S RECEPTION
Authors: Malivskyi Anatolii M.
Published: July 2016

Purpose. The article is aimed to figure out the features of Husserl's reception of anthropological Descartes rationalism. Its implementation requires a consistent solution of the following tasks: 1) schematically express a modern vision of the basic intentions of philosophizing as an anthropological rationalism; 2) highlight the main points of the Husserl's reception of Descartes’ rationalism as the deanthropologizing and analyze radicalization of its basic design as the reanthropologizing. Conclusions. When clarifying the question of the method of reception and completion of the philosophical Descartes’ project in the doctrine of Edmund Husserl, the author finds that the originality of his reception of anthropological Descartes’ rationalism appears as the paradoxical union of denying the existence of anthropology in the base project and the rediscovery of its key role in the radicalization of Descartes. Thinking of its way, he comes to the rediscovery some of the key ideas of the French philosopher, rooted in his anthropological rationalism. Among them is the basic intention of the ambivalence, the rejection of Descartes’ ideas of panrationalism, recognition irreducibility of philosophical method to the mathematical, constitutive of human presence in the new rationalism. Prospects for further research in understanding the author sees a meaningful relationship and continuity of the two great thinkers - namely, the personal nature of philosophizing and the ethical focus of their searching. Originality. Appeal to the reception of Husserl's Cartesian project confirms the thesis of an essential importance for the basic anthropological project of Descartes. The presented version of Husserl reception base project Descartes is a reproduction of the surface age stereotypes, which link the quest of the philosopher with the natural sciences and neglected anthropological measurements. The proposed version of the radicalization of Descartes’ project is largely rediscovery of the key importance of anthropological measurements in the quest for the founder of rationalism. Although Husserl himself afraid of phenomenology transformation into anthropology, significant trends anthropologization rationalism for his pursuit is certain.
MARTIN HEIDEGGER’S BLACK NOTEBOOKS AND POLITICAL ECONOMY OF CONTEMPORARY PHILOSOPHICAL CRITIQUE
Authors: Karpenko A. O.
Published: July 2016

The purpose of the study is to determine the key strategies of philosophical criticism of Heidegger’s Black Notebooks, whose achievement is realized in the following tasks: 1) to identify the body of texts that represent the discourse of philosophical criticism of Heidegger notes; 2) to reveal the typological features of the different strategies of interpreting Black Notebooks; 3) to reconstruct a thematic horizon of Heidegger studies, opened up by discussion on published notes. The methodology combines elements of discourse analysis with traditional methods of historical and philosophical criticism. Scientific novelty is expressed in the following: 1) philosophical discourse of the Notebooks’ reception includes texts of narrowly specialized character (Gatherings collection of articles), as well as reflections of key philosophers (A. Badiou, J.-L. Nancy) 2) basic strategies in philosophical critique of Black Notebooks convey the overall structure of the discourse of interpretation of Heidegger’s legacy, distributed between apologetics and ideological criticism; 3) Black Notebooks have exacerbated the problem of architectonics of Gesammtausgabe and formed the textual basis for the study of "silence" period in philosophical life of Heidegger. Conclusions. The discourse of philosophical critique of Heidegger’s notes proves evidence for ideological charge of philosophizing and justifies socially oriented approaches of historical and philosophical studies examining philosophizing as a special cultural practice, not as a form of sublime creativity.
Cardiogenic Shock and Respiratory Failure in a Patient With Metastatic Melanoma Receiving Trametinib Therapy
Authors: Tseng Diane , Mason Xenos L. , Neilan Tomas G. , Sullivan Ryan J.
Published: July 2016

Life-threatening heart failure can occur with trametinib therapy and is reversible. This article provides recommendations for evaluation of patients receiving trametinib, including those who develop severe cardiomyopathy.
Railway infrastructure assurance for Heathrow Express
Authors: Tully Kieran , Yates Andy
Published: July 2016

The purpose of this paper is to show that the assurance process by railway infrastructure managers is not overly onerous and can benefit the project by identifying risks at an early stage in the project’s life cycle and provide guidance on acceptable control measures. The control measures adopted can provide a greater level of certainty on project risk, cost and programme. This paper looks at project risk, operational risk and strategic risk exported by the 2012 London temporary departure terminal as a case study to illustrate the assurance process. It describes how the project is presented to the review panel, how the project is assessed and the control measures adopted for low-, medium- and high-risk projects. The paper details requirements for a tunnel monitoring plan where applicable and the ongoing emergency preparedness planning during the life cycle of the project. It covers the completion of the project with regard to the interface with the Heathrow Express infrastructure.
Образование как стратегический ресурс
Authors: Головин Юрий Алексеевич
Published: July 2016

В статье автор анализирует современную систему образования и отмечает, что на сегодняшнем этапе развития цивилизации глобальное, повсеместное, насильственное внедрение либеральных ценностей и либеральной идеологии отменило, в конечном итоге, общечеловеческие ценности, мораль, нравственность. Либеральному, рыночному обществу не нужны личности, а, следовательно, вообще не нужно фундаментальное гуманитарное образование, воспитывающее эти личности — нужны послушные исполнители и активные потребители. 
Международная научная конференция «Цивилизационная идентичность в современном мире. Философия — Культура — Политика» (26–27 мая 2016 г., г. Москва)
Authors: Костина Анна Владимировна
Published: July 2016

В статье представлен обзор работы Международной научной конференции «Цивилизационная идентичность в современном мире. Философия — Культура — Политика», которая прошла в Московском гуманитарном университете 26–27 мая 2016 г.
Формы коммуникативного сотрудничества в вузе в условиях информационно-технологических перемен
Authors: Коханая Ольга Евгеньевна
Published: July 2016

Создание в вузе учебных студенческих медиаструктур, где студенты приобретают навыки, необходимые им в дальнейшей профессиональной деятельности,  в современных условиях представляется по-настоящему актуальным. При использовании метода моделирования и проектной методики создается особая учебно-воспитательная среда, когда учебно-практическая деятельность имеет моделирующую функцию.
Вышло в свет пятитомное собрание сочинений И. М. Ильинского
Authors: Луков Валерий Андреевич , Захаров Николай Владимирович
Published: July 2016

В статье анонсируется новое издание 2016 года — собрание сочинений в пяти томах доктора философских наук, профессора, ректора Московского гуманитарного университета И. М. Ильинского.
Intervención en la planificación de la escritura en primer curso de Enseñanza Primaria || Intervention in writing planning processes in first-grade primary school students
Authors: Roldán-Prego Lucía , González-Seijas Rosa María
Published: July 2016

El objetivo de este trabajo fue analizar la eficacia de un programa de intervención en el proceso de planificación de la escritura de narraciones (cuentos) y descripciones en alumnos de primer curso de primaria. Los participantes fueron 40 niños de una escuela pública, de los cuales 20 recibieron instrucción en el programa (grupo experimental), mientras que los otros 20 no recibieron ninguna instrucción adicional (grupo control). En el grupo experimental tenían una media de edad de 6.7 años y en el grupo control 6.4 años. El programa se desarrolló en 15 sesiones de 45 minutos de duración, tres veces a la semana. Los niños fueron evaluados antes y después de la aplicación del programa utilizando una adaptación de los criterios de Tindal y Hasbrouck (1991). Los resultados muestran mejoras significativas en los procesos de planificación de la escritura en el grupo experimental, sobre todo en la generación de ideas y en su organización. Estos resultados tienen implicaciones directas en educación, ya que plantean estrategias para intervenir en el proceso de planificación de la escritura en el aula.
Perfil psicopatológico en adolescentes con problemas graves del comportamiento || Psychopathological profile adolescents with serious behavioral problems
Authors: Orrego José Manuel , Paino María Mercedes , Fonseca-Pedrero Eduardo
Published: July 2016

El principal objetivo de este estudio fue tratar de concretar cuáles son los diferentes rasgos psicopatológicos y comportamentales de los alumnos “altamente perturbadores” que son considerados por las autoridades educativas del Principado de Asturias, España como el colectivo con más dificultades para la intervención escolar ordinaria. Se ha seleccionado una muestra representativa de 43 alumnos con estas características, 41 varones, con una media de edad de 13.35 años (DT=1.06) y se ha comparado su perfil con un grupo control normal de alumnos. Los resultados indicaron que los alumnos con comportamientos perturbadores presentaron mayores puntuaciones medias en la mayoría de las escalas del “Inventario multifásico de la personalidad de Minnesota para adolescentes” que el Grupo Control de comparación. También los alumnos con estos comportamientos mostraron mayores puntuaciones medias en los síndromes generales del “Youth self report” en comparación con el anterior Grupo Control. Estos resultados permiten identificar y describir un perfil psicopatológico característico de este tipo de colectivo educativo, con el fin de establecer y mejorar las estrategias y programas de intervención. Futuras investigaciones deberían llevar a cabo seguimientos longitudinales, así como el análisis de otros marcadores de riesgo, como endofenotipos.
Maturidade psicológica e independência financeira: um estudo com adultos emergentes universitários || Psychological maturity and financial independence: A study with college emerging adults
Authors: Andrade Claudia
Published: July 2016

Nas últimas décadas assistiu-se a um conjunto de alterações sociais que exercem influência sobre os modos como a transição para a idade adulta é efetuada, bem como a importância que é dada aos critérios para que se seja considerado adulto. O presente estudo explora os critérios associados à representação de adulto, junto de uma amostra de adultos emergentes a frequentar o ensino superior. O estudo de natureza qualitativa foi efetuado com recurso à técnica dos grupos focais. Os resultados permitiram destacar a importância de dois critérios, um dos critérios de natureza psicológica (maturidade psicológica) e um de caráter instrumental (independência financeira) como sendo os marcadores que aparecem associados à representação do estatuto social de adulto. Outros critérios como competências familiares, transições normativas, adesão às normas e parâmetros biológicas, legais e a acontecimentos sociais, como casar, por exemplo, são, de uma forma geral, percecionados como pouco relevantes na definição da idade adulta. Os resultados são discutidos e analisados no quadro da adultez emergente em estudantes do ensino superior.
Lego Robots & Autism Spectrum Disorder: a potential partnership?
Authors: Costa Sandra , Soares Filomena , Santos Cristina , Pereira Ana , Moreira Maria
Published: July 2016

Individuals with autism spectrum disorder (ASD) present difficulties in developing social behaviours, in communicating gestural or verbally, and they may present some repetitive motor activities. The objective of this study was to improve social competences and to enable the transfer of acquired skills of five children with ASD and intellectual disabilities using a low-cost Lego robot as a mediator. The proposed methodology was divided in five phases: Familiarization, Pre-test, Practice, Post-Test and Transfer of Skills. The study ran in two sequential periods at different places. Each of these periods tackled different individual research questions and goals (taking into account the target group). During each period, the proposed methodology had to be adjusted according to the current context. Therefore, different experimental scenarios and corresponding specific goals had to be delineated. Results show that joint attention of the children increased over the sessions; and interaction with the researcher was verified. Furthermore, results show that there was an effective transfer of skills in the addressed case studies. This reinforces conclusions that robots seem, in fact, powerful tools that should be explored concerning this target population. But a more detailed study is required. The proposed methodology can be used by professionals and parents as a complement to common interventions.
Transpositions Within User-Posted YouTube Lyric Videos: A Corpus Study
Authors: Plazak Joseph
Published: July 2016

There are many practical reasons why experiences of a given musical work tend to be heard repeatedly at the same pitch transposition level, especially recordings of musical works.  Yet here, a corpus study is presented that challenges this very basic assumption of music perception.  In 2011, an initial corpus of 100 user-posted YouTube videos was collected in order to investigate the prevalence of transposition and tempo alterations within these videos.  Results found 42% of these videos contained nominal changes of pitch (36%) and/or tempo (22%). Using the same methodology, a follow-up study was performed in 2015 and found only that 24% of user-posted videos contained these same alterations. Implications for these observations are discussed in light of musical communication models, YouTubeology, and absolute pitch memory.
Big Data, Big Questions: A Closer Look at the Yale–Classical Archives Corpus (c. 2015)
Authors: De Clercq Trevor
Published: July 2016

This paper responds to the article by Christopher White and Ian Quinn, in which these authors introduce the Yale-Classical Archives Corpus (YCAC). I begin by making some general observations about the corpus, especially with regard to ramifications of the keyboard-performance origins of many pieces in the original MIDI collection. I then assess the accuracy of the scale-degree and local-key fields in the database, which were generated by the Bellman-Budge key-finding algorithm. I point out that some of the inaccuracies from the key-finding algorithm's output may influence the results we obtain from statistical studies of this corpus. I also offer an alternative analysis to the authors' finding that the ratio of V7 to V chords increases over time in common-practice music. Specifically, I conjecture that this finding may be the result of (or related to) increasing instrumental resources over time. I close with some recommendations for future versions of the corpus, such as enabling end users to help repair transcription errors as well as offer ground truths for harmonic analyses and key area information.
Treatment modalities for hyperpigmented skin lesions: A brief overview
Authors: Khoo Yan Teng , Halim Ahmad Sukari
Published: July 2016

Skin hyperpigmentation involves a broad range of skin conditions, including epidermal pigmented lesions, dermal pigmented lesions, and mixed pigmented lesions. Treatment includes various modalities such as brightening cream, chemical peeling, and laser therapy. Responses to various treatment modalities can be quite varied depending on the type of treatment and the degree of pigmentation. Sometimes a lesion can lighten or even partially disappear, while other lesions may recur. This paper provides a brief overview of treatment modalities available for hyperpigmented skin lesions including the importance of photoprotection, various types of brightening creams, suitable types of chemical peels, specific laser therapies targeted for skin hyperpigmentation, and surgery.
Curcumin augments cytostatic and anti-invasive effects of mitoxantrone on carcinosar-coma cells in vitro
Authors: Luty Marcin , Kwiecień Edyta , Firlej Magdalena , Łabędź-Masłowska Anna , Paw Milena , Madeja Zbigniew , Czyż Jarosław
Published: July 2016

Numerous adverse effects limit the applicability of mitoxantrone for the treatment of drug-resistant tumors, including carcinosarcoma. Here, we estimated the additive effects of mitoxantrone and curcumin, a plant-derived biomolecule isolated from Curcuma longa, on the neoplastic and invasive potential of carcinosarcoma cells in vitro. Curcumin augmented cytostatic, cytotoxic and anti-invasive effects of mitoxantrone on Walker-256 cells. It also strengthened inhibitory effects of mitoxantrone on the motility of drug-resistant Walker-256 cells that had retained the viability after long-term mitoxantrone/curcumin treatment. Thus, curcumin reduces the effective doses of mitoxantrone and augments its interference with the invasive potential of drug-resistant carcinosarcoma cells.
¿Quimera o Fénix? El recorrido europeo y latinoamericano hacia un derecho común de contratos
Authors: Ferrante Alfredo
Published: July 2016

En el trabajo se realizan algunas reflexiones críticas sobre el proceso de unificación del derecho privado europeo que, después de un cuarto de siglo, se encuentra en un proceso menguante y vacilante. Al mismo tiempo se hace hincapié en las nuevas iniciativas que se han creado en Latinoamérica y en la importancia que la Convención de Viena sigue revistiendo en la actualidad en ambos continentes.
Los requisitos del vicio redhibitorio en la compraventa según el Código Civil chileno-colombiano
Authors: Oviedo Albán Jorge
Published: July 2016

El presente artículo aborda el estudio de los requisitos que debe presentar el vicio redhibitorio en el contrato de compraventa: graves, ocultos y anteriores al contrato, como supuesto de la acción redhibitoria y de la acción de rebaja de precio, según su regulación en el Código Civil de Chile y Colombia. A partir del estudio de las normas, la doctrina y la jurisprudencia de ambos países, con elementos de derecho comparado, se identifican los problemas recurrentes que se han presentado en casos decididos por los tribunales chilenos y colombianos, así como los aspectos objeto de debate doctrinal surgidos a propósito de cada uno de tales requisitos y las soluciones propuestas.
El cumplimiento específico de los contratos de servicio en el derecho español: perspectivas sustantiva y procesal
Authors: Severin Fuster Gonzalo
Published: July 2016

Este trabajo pretende analizar, en el derecho español vigente, en qué medida es posible afirmar que, tratándose de contratos de servicios, el cliente tiene derecho a obtener el cumplimiento específico en caso de incumplimiento contractual. Debido a la existencia de un derecho al cumplimiento específico o in natura, y por su carácter “preferente”, este remedio puede – y debe– analizarse desde dos perspectivas que, si bien son complementarias, son diferentes. Una es la perspectiva sustantiva y la otra es la perspectiva procesal. Este trabajo aborda y desarrolla ambas perspectivas.
Reglas supletivas “sancionatorias” en el derecho de contratos colombiano: el caso del contrato de transporte
Authors: Monroy C. Daniel A.
Published: July 2016

A finales de la década de 1980, Ayres y Gertner propusieron una controversial teoría sobre cómo integrar el contenido de lagunas en contratos incompletos, acuñando la noción de “penalty default rule” (regla supletiva sancionatoria) para referirse a aquella regla que “sanciona” el silencio de las partes integrando al contrato una regla supletiva que “no” coincide con lo que la mayoría de las partes hubiesen querido. Bajo esta premisa, el artículo pretende demostrar que dichas reglas supletivas sancionatorias existen en el derecho de contratos colombiano. Así, (I) propone una metodología para identificar situaciones contractuales hipotéticas donde conviene establecer reglas supletivas sancionatorias; (II) somete a prueba la metodología a la luz del principal caso de estudio descrito por Ayres y Gertner, y (III) replica la metodología con un caso propio del derecho de contratos colombiano.
La aplicación de la acción por daño contingente en Chile, Colombia y Ecuador: del modelo de Bello a nuestros días
Authors: Diez Schwerter José Luis
Published: July 2016

Este trabajo tiene por finalidad analizar la aplicación de la original acción general por daño contingente que Andrés Bello aportó a la codificación latinoamericana, con especial interés en los textos chileno, colombiano y ecuatoriano de responsabilidad civil, partiendo de la base de que en ellos se comparte un mismo modelo normativo general: el Código Civil chileno (promulgado el 14 de diciembre de 1855, y adoptado luego en Colombia y Ecuador), por medio de su consagración expresa en dichos países, evidenciando el estado de su aplicación y disímil evolución entre ellos.
La oposición eficaz. Análisis basado en el proceso monitorio del Código General del Proceso
Authors: Corchuelo Uribe Daniela , León Gil Mónica Alejandra
Published: July 2016

El proceso monitorio es una herramienta novedosa en Colombia. Se erige como la forma más eficaz de solucionar controversias cuando los acreedores no disponen de título ejecutivo, y busca garantizar la tutela efectiva del crédito, procurando la celeridad y eficiencia de la administración de justicia. Su característica esencial es la inversión del contradictorio. Allí, el deudor manifiesta las razones por las que considera no deber, por medio de una oposición, que según el Código debe ser fundada, sin que determine su alcance. Este estudio busca dotar de contenido la oposición con el fin de ofrecer herramientas al intérprete, para que decida atendiendo a los principios del derecho procesal.
IMPLEMENTAÇÃO E AVALIAÇÃO DE UM BIODIGESTOR DE PRODUÇÃO DESCONTÍNUA
Authors: Duarte Neto Ely Dias , Alvarenga Leonardo Henrique , Costa Lilian De Melo , Nascimento Paulo Henrique , Silveira Rafael Zanini , Leite Leonardo Henrique de Melo
Published: July 2016

O desenvolvimento do ser humano está intrinsecamente ligado aos tipos de energia que teve acesso. O domínio sobre o fogo foi o primeiro grande passo para a humanidade. O uso do GAS NATURAL tem início no século XX nos EUA, mas com as exportações da Rússia, que possui a maior reserva do planeta, o gás natural tomou espaço do carvão nas termoelétricas. Hoje o gás natural se tornou o energético mais utilizado em termoelétricas e seu consumo vem crescendo em todo o mundo. Este artigo descreve um experimento de implantação de um biodigestor mostrando a equivalência entre a produção de biogás, a quantidade de material utilizado e a prática que procura prover um pequeno produtor de uma fonte energética. A biomassa, após passar pelo biodigestor e ter produzido o biogás, também tem como produto o biofertilizante, para a fertilização dos solos.
ESTUDO DAS ENERGIAS E FUNÇÕES DE ONDA
Authors: Prado Sílvio José
Published: July 2016

Neste trabalho são calculadas a estrutura eletrônica e as funções de onda de um ponto quântico cilíndrico de CdTe. O modelo utilizado para realizar o cálculo se baseia no Hamiltoniano k.p 8×8 de Kane-Weiler, o qual leva em consideração a forte mistura entre as bandas de condução e de valência, assim como permite estudar o conjunto de simetrias associadas com estes estados eletrônicos. Observe-se que, uma vez definido um cilindro de altura 2Hz, ao variar o raio o caráter do segundo e terceiro níveis de energia da banda de valência sofrem mudanças entre os estados de buraco pesado e buraco leve, devido a cruzamentos e anti-cruzamentos entre os níveis de energia.
Assessment of Balance Disorders in Patients after Ankle Fractures
Authors: Wang Cuixiao , Chen Shao , Qiao Meina , Xu Yueqing , Zhao Jinkui
Published: July 2016

Purpose: The objective of the study is to evaluate the balance disorders in patients with surgical treatment of ankle fractures with the use of Sunlight Tetrax. Methods:The subjects in the study were 20 patients with ankle fractures treated surgically（after six months of the procedure）and the control group comprised 21 healthy subjects. Two groups compare the general stability index (ST), the high frequency of Fourier transformation (F5-F6),the body weight distribution index (WDI) ,synchronicity of foot under natural standing on solid surface with eyes opened and natural standing on solid surface with eyes closed and the fall index (FI). Results: The fall index (FI) and the stability index (ST) under natural standing on solid surface with eyes opened of two groups were statistically significant differences. The balance of patients with ankle fracture after 6 months with surgical procedure is significantly poorer than healthy subjects. 
INFORMATION NEEDS OF FARM WOMEN OF UTTARAKHAND
Authors: Sharma Arpita
Published: July 2016

Farm women in Uttarakhand play an important role in managing different kinds of farming and home affairs. Information for women involved in an enterprise is important to understand the production process and the economics of production. A sample of 100 farm women was selected using Simple Random Sampling technique. The survey research design was used for data collection. Data were also collected through interview schedule. Data were analyzed using quantitative approaches. Results show that the information needs of farm women are mostly occupation driven. Farm women were found to have a need for information about dairy farming as also for home management. Most of the farm women depend on the friends, husband, neighbors and other native sources like local leaders and educated people for their information needs. Thus, their primary and most important sources of information are friends, husband, neighbors and other native sources.
ICT Productivity in Agriculture
Authors: Chhetri Anoj
Published: July 2016

This paper describes about how to apply information and communication technologies (ICTs) to solve agricultural problems. It presents research findings on Agriculture ICT (AgICT) impact on the agricultural performance. It talks about how ICT enhances extension services by applying tools such as mobile phone, SMS, call centres, etc. This papers presents some research findings on the ICT productivity stating that farmers using AgICT in farming activities have increased 5.91 % of their farm productivity compared to the immediate past year while farmers having no exposure to AgICT increased only 3.90% of farm productivity. This can apparently be assumed that the AgICT alone can contribute 2.01% increase in farm productivity.
Impediments Faced By Women SHGs under Integrated Watershed Management Programme
Authors: BARIYA M. K. , Kanani P. R. , Parmar S. J.
Published: July 2016

The present study was an attempt to identify the impediments faced by SHGs under Integrated Watershed Management Programme (IWMP). A total of 90 women self help group members as respondents were selected from Amreli district of Gujarat. The study findings revealed that the self help group women mainly encountered with the lack of knowledge in record maintenance. Their dependency on family male member was another impediment in solving money problems. Handling of bank account in which SHG Women were unaware of the rules has continuation of project and its expansion in other villages by establishing new SHG and addition of new activities have been largely suggested by most SHG-women. Although they were found not competent in performing bank formalities, yet their co-ordination among members and interpersonal trust were intact. Internal loaning and loaning through bank, clashes in their loan taking time, lack of time for meeting, dependency on members of family, and lack of marketing information needed major reforms as suggested by SHG members.
DISTRIBUIÇÃO SAZONAL DOS SEDIMENTOS NA PRAIA DO FAROL, ILHA DO CABO FRIO, ARRAIAL DO CABO, RIO DE JANEIRO
Authors: Quadros Patrícia , Castro João Wagner de Alencar , Guedes Eliane , Pereira Victor César Ribeiro
Published: July 2016

Praias podem ser definidas como depósitos de material inconsolidados localizados na interface entre o mar e terra ou podem estar relacionadas a corpos aquosos de grandes proporções. A Ilha do Cabo Frio, localizada no município de Arraial do Cabo, extremo leste do Estado do Rio de Janeiro, é constituída por rochas alcalinas sieníticas e ortognaisses e um único depósito de praia. O presente trabalho tem como principal objetivo a caracterização dos sedimentos de praia da Ilha do Cabo Frio sob o ponto de vista sedimentológico e sazonal, utilizando o software ArcGis Desktop 10.2 para facilitar a visualização dos resultados obtidos. O método de trabalho utilizado abrangeu as seguintes fases: 1) Pesquisa bibliográfica sobre a geologia local, eventos climáticos e padrões de correntes; 2) Trabalho de campo para coleta de amostras de sedimento de praia, distribuídos nas faces de ante-praia, praia e pós-praia. Foram coletadas 42 amostras no total, sendo destas 21 no período inverno (agosto/2013) e 21 no período de verão (março/2014); 3) Processamento do material coletado onde foram feitos estudos granulométricos por processos de peneiramento e visualização e interpretação dos resultados no SEDIGRAPH; 4) Criação de mapas com a distribuição granulométrica dos sedimentos nos períodos de inverno e verão. Os resultados obtidos apontam para uma predominância de material tamanho areia média bem selecionada na etapa de inveno e de tamanho areia fina moderadamente bem selecionada na etapa verão.  A ocorrência de material mais grosso no período de inverno pode estar relacionada há uma maior concentração de frentes frias com frequentes incidências de ondas provenientes de sudeste e sudoeste, enquanto no período de verão predomina a ação de ondas de nordeste, que desempenham um importante papel na seleção do grão. As ondas de sudeste e sudoeste também favorecem o transporte de sedimentos em direção a nordeste da praia do Farol fazendo com que esta seja mais espessa neste seguimento. Já as ondas de nordeste incidem com ligeiro ângulo de ataque sobre a praia, gerando correntes que remobilizam os sedimentos da ante-praia e da face de praia em direção ao segmento sudoeste. Podemos concluir, para os sedimentos de praia da Ilha do Cabo Frio, que sua distribuição sazonal e seleção está relacionada diretamente aos eventos climáticos que ocorrem na região assim como as correntes de mobilização locais.
MORFOMETRIA DA BACIA DO RIO SÃO JOÃO, MG: UMA PROPOSTA DE ENTENDIMENTO DOS LIMITES E DA DINÂMICA DAS SUPERFÍCIES EROSIVAS
Authors: Soares Samia Passarella , Ladeira Francisco Sérgio Bernardes , Liesenberg Veraldo
Published: July 2016

Os parâmetros morfométricos da superfície do relevo são essenciais para a caracterização e o entendimento da formação de uma paisagem, especialmente em áreas que passaram por processos erosivos e tectônicos bem marcados, como o caso da região da Bacia do Rio São João, no sudoeste de Minas Gerais. Com o propósito de reconhecer os traços tectônicos que pudessem interferir no desenvolvimento do canal e por fim afetar os ciclos erosivos, foram realizadas uma série de análises geomorfológicas; tais como a Isobase, o Fator de simetria topográfica transversal com assimetria da bacia de drenagem  e a Curva e integral hipsométrica. Estes índeces foram produzidos através do software TecDEM, que compilou em sua interfacie de trabalho todo o procedimento e rotina, utilizando-se apenas das informações espaciais do modelo digital de elevação (SRTM). Estas análises, favoreceram satisfatoriamente o entendimento das estruturas e do relevo no contexto da bacia, assim evidenciando os domínios topográficos e limites das superfícies, a dinâmica erosiva,  o deslocamento dos canais pertencentes as bacias de quarta e quinta ordem, e por fim o momento de transição do relevo.
GEOMORFOLOGIA DOS MACIÇOS DE PORTALEGRE E MARTINS – NE DO BRASIL: INVERSÃO DO RELEVO EM ANÁLISE
Authors: Maia Rúbson Pinheiro , Bétard François , Bezerra Francisco Hilário
Published: July 2016

Os processos que levam a inversão do relevo podem ocorrer quando há um alçamento de uma determinada superfície pela tectônica ou pela erosão diferencial. Nesse processo, antigas áreas agradacionais podem ser alçadas a cotas elevadas, transformando baixos em altos topográficos. Níveis sedimentares preservados sobre superfícies elevadas podem constituir importantes indicadores de processos de inversão do relevo, uma vez que constituem um antigo nível de base deposicional. No Nordeste Brasileiro, vários maciços cristalinos apresentam-se parcialmente recobertos pela Formação Serra dos Martins (FSM), que constitui uma unidade sedimentar de origem continental situada entre as cotas 650 e 700m. Os sistemas deposicionais da FSM já são bem conhecidos, mas sua cronologia foi e ainda é fruto de discussões que embasam diferentes modelos de evolução geomorfológica. Nesse trabalho foram analisados diferentes aspectos da evolução geológica e geomorfológica em contraposição as tentativas de posicionamento cronológico absoluto e relativo da FSM. Por fim, concluímos que as reativações tectônicas cenozoicas ao longo da zona de cisalhamento Portalegre e o soerguimento cenozoico resultante do vulcanismo neógeno (underplating) contribuíram para a alteração dos níveis de base de erosão levando à dissecação. A resistência associada a litologia granítica das suítes intrusivas e o capeamento laterítico contribuíram para a erosão diferencial do embasamento circunjacente, levando a inversão do relevo que resultou na elevação da Formação Serra dos Martins as suas cotas atuais.