bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Strategi Marketing Mix dan Brand Image Terhadap Loyalitas Pelanggan Minimarket Alfamart di Gandaria Jakarta Selatan
Authors: Ningsih Fery Herna
Published: May 2022

Strategi Marketing Mix merupakan kunci keberhasilan penyampaian produk kepada konsumen atau calon konsumennya. Citra Merek memberikan keyakinan kepada konsumen terhadap produk yang dibelinya. Dengan terpenuhinya kebutuhan konsumen akan suatu produk akan menimbulkan loyalitas pelanggan. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh Bauran Pemasaran dan Citra Merek terhadap loyalitas pelanggan , baik secara simultan maupun parsial. Metode yang digunakan dalam penelitian ini adalah metode survey teknik  korelasional. Analisis data yang digunakan adalah korelasi sederhana, korelasi parsial, korelasi ganda, regresi sederhana dan regresi ganda. Hasil uji hipotesis menyimpulkan: (a) terdapat hubungan positif antara X1 dengan Y sebesar () = 0,5223; persamaan regresi Ŷ = 38,72 + 0,63X1; kontribusi X1 terhadap Y sebesar 27,28%, (b) terdapat hubungan positif antara X2 dengan Y sebesar () = 0,4471; persamaan regresi Ŷ = 53,84 + 0,47X2; kontribusi X2 terhadap Y sebesar 19,99%, (c) terdapat hubungan positif antara X1 dan X2 secara simultan terhadap Y sebesar 0,5730; persamaan regresi Ŷ= 25,85 + 0,481X1 + 0,275X2; kontribusi X1, dan X2 terhadap Y sebesar 32,83%, artinya bahwa 32,83% variabel bauran pemasaran dan citra merek memberi sumbangan (kontribusi) terhadap loyalitas pelanggan, sedang sisanya 67,17 % dipengaruhi oleh variabel lain. Berdasarkan penelitian ini dasarankan (1) Peningkatan Strategi Marketing Mix yaitu digital marketing. Dengan digital marketing pesan yang disampaikan cepat sehingga menimbulkan pembelian berulang dan menambah konsumen baru. (2) Memiliki identitas pembeda dan karakter yang unik untuk menunjukkan kosistensi perusahaan. (3) Meneruskan konsistensi perusahaan dengan cara mempertahankan kualitas produk, mempertahankan karakter brand, mempertahankan hubungan baik dengan konsumen dan berbagai aspek lainnya.Kata Kunci: Strategi Marketing Mix, Brand Image dan Loyalitas Pelanggan
Deskripsi Karakter Gemar Membaca Pada Mata Pelajaran IPA Di Sekolah Menengah Pertama
Authors: Firmansyah Riko , Zain Muhammad Sofyan
Published: May 2022

Tujuan penelitian: Penelitian ini dilakukan untuk mengetahui kegemaran membaca siswa SMP melalui 4 indikator antara lain sikap umum terhadap membaca IPA, preferensi membaca IPA, efek membaca terhadap kemampuan siswa, dan pandangan positif siswa terhadap membaca sehingga berguna bagi pembaca agar mengetahui bagaimana kondisi kesenangan membaca siswa SMP saat ini
Metodologi: Penelitian dilakukan di SMPN 19 Kota Jambi, SMP Xaverius 2 Jambi, dan SMPN 17 Kota Jambi dengan jumlah sampel sebanyak 411 orang siswa dari kelas VII, VIII, dan IX dengan teknik sampling yang digunakan adalah cluster sampling. Desain penelitian yang digunakan adalah explanatory design. Instrumen kuantitatif berupa instrumen kesenangan membaca terdiri dari 38 butir pernyataan, sedangkan instrumen kualitatif berupa interview kepada 9 siswa dari 3 sekolah. Teknik pengumpulan data dilakukan dengan survei (field research).
Temuan utama: Hasil penelitian ini menunjukkan indikator sikap umum terhadap membaca berada pada skala netral, indikator preferensi membaca berada pada skala netral, indikator efek membaca terhadap kemampuan berada pada skala setuju, indikator pandangan negatif siswa terhadap membaca berada pada skala tidak setuju. Hasil wawancara hasil wawancara dengan siswa menunjukkan bahwa kegemaran membaca siswa sudah baik.
Keterbaruan penelitian: Sikap umum terhadap membaca merupakan indikator yang menunjukkan bagaimana pandangan positif siswa tentang berbagai hal mengenai membaca secara umum. Indikator ini akan diukur oleh peneliti untuk mengetahui baik atau tidaknya membaca untuk siswa.
variedades de la experiencia abductiva
Authors: Duarte Antonio
Published: May 2022

Siguiendo la propuesta de Peirce en su Argumento Olvidado, en este artículo trataremos de observar la equivalencia generativa y metodológica de lo que llamaremos las experiencias abductivas religiosas y científicas. Para articular estas conexiones, nos apoyaremos también en las conferencias Gifford de William James (1901-1902) reunidas bajo el título Las variedades de la experiencia religiosa. Estudiaremos ampliamente, además, la universalidad de los procesos mentales que llevan a la generación de las abducciones más creativas y que Peirce denominó Musement; para finalizar, trataremos de justificar esta universalidad por un descubrimiento muy reciente de la neurociencia, la red neural por defecto.
Chemistry of polyhalogenated nitrobutadienes, 17: Efficient synthesis of persubstituted chloroquinolinyl-1H-pyrazoles and evaluation of their antimalarial, anti-SARS-CoV-2, antibacterial, and cytotoxic activities
Authors: Zapol’skii Viktor A , Berneburg Isabell , Bilitewski Ursula , Dillenberger Melissa , Becker Katja , Jungwirth Stefan , Shekhar Aditya , Krueger Bastian , Kaufmann Dieter E
Published: May 2022

A series of 26 novel 1-(7-chloroquinolin-4-yl)-4-nitro-1H-pyrazoles bearing a dichloromethyl and an amino or thio moiety at C3 and C5 has been prepared in yields up to 72% from the reaction of 1,1-bisazolyl-, 1-azolyl-1-amino-, and 1-thioperchloro-2-nitrobuta-1,3-dienes with 7-chloro-4-hydrazinylquinoline. A new way for the formation of a pyrazole cycle from 3-methyl-2-(2,3,3-trichloro-1-nitroallylidene)oxazolidine (6) is also described. In addition, the antimalarial activity of the synthesized compounds has been evaluated in vitro against the protozoan malaria parasite Plasmodium falciparum. Notably, the 7-chloro-4-(5-(dichloromethyl)-4-nitro-3-(1H-1,2,4-triazol-1-yl)-1H-pyrazol-1-yl)quinoline (3b) and 7-chloro-4-(3-((4-chlorophenyl)thio)-5-(dichloromethyl)-4-nitro-1H-pyrazol-1-yl)quinoline (9e) inhibited the growth of the chloroquine-sensitive Plasmodium falciparum strain 3D7 with EC50 values of 0.2 ± 0.1 µM (85 ng/mL, 200 nM) and 0.2 ± 0.04 µM (100 ng/mL, 200 nM), respectively. Two compounds (3b and 10d) have also been tested for anti-SARS-CoV-2, antibacterial, and cytotoxic activity.
ORTAOKUL SÖZLÜ ANLATIM ÖZ YETERLİK ALGI ÖLÇEĞİ: GEÇERLİK VE GÜVENİRLİK ÇALIŞMASI
Authors: DEMİR Selvi , BÖREKÇİ Muhsine
Published: May 2022

Bu araştırmada ortaokul öğrencilerinin sözlü anlatım öz yeterlik algılarını belirleyebilmek için bir veri toplama aracı geliştirmek amaçlanmıştır. Bu doğrultuda ilk olarak 2018 Türkçe Dersi Öğretim Programı’nda yer alan kazanımlar, Gee’nin söylem çözümleme basamakları ve ilgili alanyazın sözlü anlatım öz yeterlik açısından incelenerek madde havuzu oluşturulmuştur. Oluşturulan 70 maddelik deneysel formun, ön uygulama olarak 112 ortaokul öğrencisiyle “Sesli Düşünme Yöntemi” kullanılarak anlaşılırlık ve seviye bakımından uygunluğu test edilmiştir. Daha sonra deneysel form uzman görüşüne sunulmuştur. Uzman görüşleri doğrultusunda oluşturulan ölçeğin taslağı 334 ortaokul öğrencisine uygulanmıştır. Açımlayıcı faktör analizi sonucunda deneysel formun iki faktörlü modele uygun olduğu belirlenmiştir. Faktörlerin tümünün açıkladığı varyans yüzdesi %69; ölçeğin tüm maddeleri için güvenirlik katsayısı Cronbach alfa .86 olarak hesaplanmıştır. Doğrulayıcı faktör analizi için 832 ortaokul öğrencisine uygulanan ölçekten elde edilen verilerin analiz sonuçlarının uyumlu olduğu ve önerilen modelin kabul edilebilir olduğu sonucuna ulaşılmıştır. Ölçeğe son hâli verildikten sonra Cronbach alfa değeri .89 olarak belirlenmiştir. Mplus programı aracılığıyla yapılan analizlerde 4’lü Likert tipinde 27 maddelik sözlü anlatım öz yeterlik algı ölçeği geliştirilmiştir. Ulaşılan sonuçlar, OSAÖYAÖ’nün geçerli ve güvenilir bir ölçme aracı olduğunu ortaya koymaktadır.
ÖĞRETMENLERİN STEM EĞİTİMİNE YÖNELİK FARKINDALIK, TUTUM VE SINIF İÇİ UYGULAMA ÖZYETERLİK ALGILARININ İNCELENMESİ
Authors: YAMAN Fikriye , AŞILIOĞLU Bayram
Published: May 2022

Bu araştırmayla öğretmenlerin STEM eğitimine yönelik farkındalık, tutum ve sınıf içi uygulama özyeterlik algılarının incelenmesi amaçlanmıştır. Çalışmada betimsel araştırma yöntemi benimsenmiştir. Araştırmanın evrenini, 2018-2019 eğitim öğretim yılında Diyarbakır ili merkez ilçelerindeki (Bağlar, Kayapınar, Sur ve Yenişehir) ilkokullarda görev yapan sınıf öğretmenleri, ortaokullarda görev yapan fen bilimleri, matematik, bilişim teknolojileri ve teknoloji tasarım öğretmenleri oluşturmaktadır. Araştırma kapsamında 609 öğretmene ulaşılmıştır. Araştırmanın verileri; Çevik (2017) tarafından geliştirilen “STEM Farkındalık Ölçeği”; Yaman (2020) tarafından geliştirilen “STEM Eğitimine Yönelik Tutum Ölçeği” ve “STEM Sınıf İçi Uygulama Özyeterlik Algı Ölçeği” ile toplanmıştır. Araştırma sonuçlarına göre; öğretmenlerin STEM eğitimine yönelik farkındalık düzeyleri, ölçeğin; “Öğrenciye Etkisi” ve “Öğretmene Etkisi” alt boyutlarında yüksektir. Öğretmenlerin STEM eğitimine yönelik farkındalık düzeyleri, ölçeğin; “Derse Etkisi” alt boyutunda ve orta düzeydedir. Öğretmenlerin, STEM eğitimine yönelik tutumları olumludur. Öğretmenlerin STEM eğitimine yönelik sınıf içi uygulama özyeterlik algıları, hem ölçeğin genelinde hem de alt boyutlarda olumludur.
MATEMATİK UYGULAMALARI DERSİNİN VARLIĞI VE SEÇİM SÜRECİ
Authors: ALBAYRAKOĞLU Özlem , KILIÇ Abdurrahman
Published: May 2022

Seçmeli Matematik Uygulamaları (MU) dersinin varlığına ve seçim sürecine dair öğrenci ve öğretmen görüşlerinin incelenmesinin amaçlandığı bu araştırma nitel yaklaşıma göre yapılandırılmış bir durum çalışmasıdır. Araştırma sürecinde; ortaokul matematik öğretmenleri ve MU dersini yürüten diğer branş öğretmenleriyle görüşmeler, MU dersi öğrencileriyle ise görüşmeler ve odak grup görüşmeleri yapılarak veri toplanmıştır. Verilerin analizinde içerik analizi yöntemi kullanılmıştır. Sonuçlara göre, MU dersi bilişsel ve duyuşsal gelişimi destekleyen, işbirlikli öğrenme becerisi geliştiren, matematik dersine takviye olan ve merkezî sınavlara hazırlık çalışmaları yapılabilmesine fırsat veren varlığı olumlu bir ders olarak algılanmaktadır. Fakat merkezî sınavlara hazırlık için etüt dersi olarak algılanması MU Dersi Öğretim Programı’nın amaçları ile uyuşmamaktadır. Diğer yönden, MU dersi altyapı eksikliği, öğrencilerin dersi ciddiye almaması, ders içeriğinin yetersiz bulunması ve matematik dersinin devamı niteliğinde yürütülmesi nedeniyle varlığı olumsuz bir ders olarak değerlendirilmektedir. MU dersinin seçim aşamasında öğrencilerin veliler, öğretmenler ve okul yönetimi tarafından yönlendirildikleri belirtilmektedir. Özetle, seçmeli ders misyonuna aykırı olarak MU dersinin seçim aşamasında genellikle öğrencilerin özgürce hareket edemedikleri ve yetenekleri-istekleri doğrultusunda bu dersi seçemedikleri görülmektedir.
OKUL PSİKOLOJİK DANIŞMANLARININ DAVRANIM SORUNLARI GÖSTEREN LİSE ÖĞRENCİLERİYLE ÇALIŞMA DENEYİMLERİ
Authors: KILIÇ Cafer , ŞENSOY Gözde , İKİZ Ebru
Published: May 2022

Davranım sorunları gösteren öğrencilere okul ortamında müdahale edilmesinde sorumluluk alan kişilerin başında okul psikolojik danışmanları gelmektedir. Bu öğrenciler, okul psikolojik danışma ve rehberlik servisine en fazla gelen/yönlendirilen grupların başında gelmektedir. Saldırganlık, madde kullanımı, istismar, zorbalık, kendine zarar verme eğilimleri olan öğrencilerin bireysel sorunları akran ilişkileri, akademik başarı, suça sürüklenme gibi farklı alanlarda çeşitli sorunlara da neden olmaktadır. Olumsuz, hayati ya da adli sorunlar yaşanmadan bu öğrencilere erken müdahalede bulunulması gerekmektedir. Bu çalışmanın amacı okul psikolojik danışmanlarının davranım sorunları gösteren öğrencilerle çalışma deneyimlerini çok yönlü incelemektir. Bu araştırma nitel araştırma yaklaşımına göre tasarlanmıştır. Uşak ilindeki liselerde çalışan okul psikolojik danışmanlarından maksimum çeşitlilik örnekleme yöntemiyle ulaşılan 15 okul psikolojik danışmanı ile nitel görüşmeler yapılmıştır. Nitel verilerin analizi sonucunda yaygın davranım sorunları, davranım sorunlarının nedenleri, kullanılan yaklaşım ve teknikler, iş birliği ve ihtiyaçlar ortaya çıkmıştır.
BİRİNCİ VE İKİNCİ SINIFTA OKUMA BECERİLERİNİN GELİŞİMİ VE MATTHEW ETKİSİ: BOYLAMSAL BİR ÇALIŞMANIN SONUÇLARI
Authors: ERGÜL Cevriye , BAHAP KUDRET Zeynep , AKOĞLU Gözde , ÖKCÜN AKÇAMUŞ Meral Çilem , KILIÇ TÜLÜ Burcu , DEMİR Ergül
Published: May 2022

Bu çalışmada çocukların okuma performansları birinci sınıftan ikinci sınıfın sonuna kadar boylamsal olarak izlenmiş ve düşük okuma başarısının çocuklar arasında ne oranda gözlendiği, birinci sınıfta gözlenen performansın ikinci sınıfta ne oranda sürdürüldüğü, performanslarında Matthew etkisi gözlenip gözlenmediği ve farklı düzeylerde okuma başarısı gösteren çocukların ne tür SED ve cinsiyet özellikleri gösterdikleri betimsel olarak incelenmiştir. Ankara’daki 45 okulda yürütülen çalışmaya tipik gelişim gösteren toplam 427 çocuk katılmıştır. Çocukların okuma performansları Okuma Yazma Değerlendirme Bataryası (OYAB) kullanılarak birinci ve ikinci sınıf boyunca dört kez değerlendirilmiştir. Elde edilen sonuçlar düşük okuma performansı gösteren çocukların oranının %34 olduğunu, birinci sınıftaki düşük okuma performansının %66,9 oranında ikinci sınıfta da sürdürüldüğünü, farklı düzeylerde okuma başarısı gösteren gruplar arasındaki farkın ilerleyen dönemlerde artarak devam ettiğini ve böylece Matthew etkisinin oluştuğunu göstermiştir. Ayrıca, alt-SED’den gelen çocukların okuma güçlükleri açısından daha yüksek risk taşıdıkları ve kızların daha büyük oranda düşük okuma başarısı gösterdikleri bulunmuştur. Sonuçlar alanyazın ve uygulamalar açısından ayrıntılı tartışılmıştır.
Influence of Service Quality on Customer Engagement with Customer Emotions as an Intervening Variable in Aman Cepat Company
Authors: Susanto Veronica Puspitasari , Herdinata Christian
Published: May 2022

Aman Cepat is a family business that runs in the shipping service sector. Aman Cepat has problems in sales which have not reached the sales target. Moreover, Aman Cepat has customer complaints regarding its ser- vice quality dimensions (personnel, outcome, and social quality), and cur- rently, competition in the expedition service sector is getting tougher. This research aims to test and analyze the influence of service quality dimen- sions towards customer emotions and the effect of customer emotions on customer engagement of Aman Cepat. The benefit of this research is that it is expected that the Aman Cepat Company can provide better quality in service. This research has novelty in the field of the industry being studied. The population of this research is the active B2B customer of the company, and the samples are 78 respondents, who were chosen using the saturated sampling method. This research uses the Partial Least Square Structural Equation Modelling. The results show those service quality dimensions have a significant influence on customer emotions, and the customer emotions variable also has a considerable influence on the customer engagement of Aman Cepat.
Technology Acceptance Model (TAM) Factors and Social Factors Analysis through Attitude towards to Use on Intention to Purchase of Kisah Kita Ngopi Online Café
Authors: Bramantyo Paskalis Dio , Utami Christina Whidya
Published: May 2022

The covid-19 pandemic has forced entrepreneurs to switch to online sales, including Kisah Kita Ngopi (KKN) Café. It is essential to know the factors that affect a customer’s Intention to Purchase when online, such as the TAM Factors (perceived usefulness, perceived ease of use) and social factors (social influence, peer influence) attitude towards to use in using online applications. This research uses the SEM data analysis method as- sisted by Partial Least Square (PLS) software. Data collection is carried out by distributing questionnaires in the form of Google forms to people in Sidoarjo and Surabaya who have made online purchases at the KKN Café. In this study, the random sampling technique obtained 85 respondents. The results of this study indicate that (1) perceived usefulness affects atti- tude toward mobile app use, (2) perceived ease of use affects attitude to- ward mobile app use, (3) social influence does not affect attitude toward mobile app use, (4) peer influence affects attitude towards mobile app use, (5) attitude towards mobile app user does not affect intention to purchase, (6) perceived usefulness does not affect intention to purchase, (7) perceived ease of use does not affect intention to purchase, (8) social influence does not affect intention to purchase, and (9) peer influence does not affect intention to purchase. Therefore, based on the results of this study, it can be concluded that the TAM factors scores are higher than those related to social factors with regards to attitude towards to use.
“WING DENTURE” FOR THE MANANGEMENT OF PROCLINED PREMAXILLA WITH LABIAL UNDERCUTA CASE REPORT
Authors: J Dhivya Priya , S Arunpriyatharsini , R Sridharan , M Mohamed Ejaj
Published: May 2022

Esthetics plays a vital role in the prosthodontic rehabilitations. In patients with proclined premaxillary region/labial undercut, it is challenging to the prosthodontist to achieve the desirable esthetics. In this article we will discussing about a non-surgical management of the proclined premaxilla in a complete denture patient using a modified flange.
Diagnosis and Management of Cracked Mandibular Molar Tooth: A Case Report
Authors: Sreeprakash Aparnna , Yadav Sanjna
Published: May 2022

A cracked tooth is a thin surface disruption of enamel and dentin, and possibly cementum, of unknown depth or extension. Depending on crack extent and crack location, treatment for cracked teeth can range from composite resin restorations or crowns to root canal treatment followed by cuspal coverage or sometimes extraction. This case report presents diagnosis and management of a cracked mandibular molar tooth with root canal treatment.
Effect of Mulligan Bent Leg Raise Technique on Low Back Pain Subjects with Radiculopathy
Authors:   Chief civil surgeon, Govt. Head Quarters Hospital, Cuddalore district, Tamil Nadu, India., Sivasubramaniyan K , Arul Pragassame Dr. S. ,   Asst Professor, Department of PMR, RMMCH, Annamalai University, Tamil Nadu, India., Srinivasan Dr. B ,   Asst Professor, Department of PMR, RMMCH, Annamalai University, Tamil Nadu, India., Jerry C ,   Department of PMR, RMMCH, Annamalai University, Tamil Nadu, India
Published: May 2022

Brain Mulligan pioneered the use of manual therapy techniques. In clinical practise, these approaches are often utilised. Among many techniques, bent leg raise is an innovative technique that is said to improve the range of straight leg raise, reduce pain, and reduce the degree of impairment in low back pain with radiculopathy. Clinical trial has not sufficiently demonstrated the efficacy of this approach. As a result, research on the effectiveness of the bent leg raise approach in low back pain with radiculopathy on pain and range of motion is required. 30 male subjects with straight leg raise limitations ranging from 300 to 700 were divided into two groups of 15 each (A and B). Mulligan bent leg raise technique, interferential therapy, intermittent pelvic traction, and spinal extension exercise were administered to Group A. Interferential therapy, intermittent pelvic traction, and spinal extension exercise were administered to Group B for 5 days. The pain and range of straight leg raise were assessed before and after treatment using the Numerical pain rating scale and a universal goniometer, respectively. In Group A, there was statistically significant reduction in NPRS score and improvement in SLR range and the calculated (t=29.078, P value=0.001), (t=22.149, P=0.001). In Group B, there was statistically significant reduction in NPRS score and improvement in SLR range and the calculated (t=20.917, P value=0.001), (t=9.287, P=0.001). When comparing Group, A and B, there was statistically significant reduction in NPRS score and improvement in SLR range was observed in group A. The study concludes that Mulligan bent leg raise is effective in reducing pain and improvement in range of straight leg raise in low back pain subjects with radiculopathy.
Optimization of an Exopolysaccharide Production from Bacillus Aerogenes by Response Surface Methodology
Authors:   Associate professor, Department of Pharmaceutical Biotechnology, Krishna Teja Pharmacy College, Tirupati. 517 506, Chandrasekaran V S , Ganesh Dr M ,   Head & Professor, Department of Biochemistry, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai., Latha Dr S ,   Assistant Professor, Department of Pharmacognosy, Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai., Umasankar Dr K ,   Head & Professor, Department of Pharmaceutics, Krishna Teja Pharmacy College, Tirupati. 517 506., Asirvatham Dr. Adlyne Reena ,   Associate Professor and Consultant, Endocrinology, Sri Ramachandra Institute of Higher Education and Research (DU)
Published: May 2022

Associate Professor and Consultant, Endocrinology, Sri Ramachandra Institute of Higher Education and Research (DU)
CRICKET ANALYSIS USING MACHINE LEARNING
Authors:   Assistant Professor,CSE, Sreyas institute of engineering and Technology, Telangana, India., P Vijaya Lakshmi , Haripriya Kanike ,   Sreyas institute of engineering and Technology, Telangana, India., Gangishetti Saipavan ,   Sreyas institute of engineering and Technology, Telangana, India., VLB Gayatri Thummalapalli ,   Sreyas institute of engineering and Technology, Telangana, India., Yarlagadda Snehith ,   Sreyas institute of engineering and Technology, Telangana, India.
Published: May 2022

This project uses machine learning algorithms to set the matter of predicting match results supported historical matches information. ML is used to predict the match result variable by developing classification models based on certain freelance variables like player’s position, their batting and bowling performances, weather, location, etc. However, we have a tendency to 1st analyze the info and train the models then it’s straightforward to predict the match results. We as a team utilize SVM and Random Forest machine learning algorithms to research and predict the result of the sport, and it'll facilitate the coaches of the team acquire knowledge and analyze, wherever really the team goes wrong and also the space of the development. the method involves preparing the model supported previous matches history, then the developed model gets evaluated on associate degree separate future match to calculate its effectiveness
HIV medication to prevent fetal infection during pregnancy
Authors:   Filantropia Clinical Hospital, Bucharest, Romania, Cioroba Teodora Gabriela , Gica Nicolae ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Filantropia Clinical Hospital, Bucharest, Romania, Botezatu Radu ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Filantropia Clinical Hospital, Bucharest, Romania, Peltecu Gheorghe ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Filantropia Clinical Hospital, Bucharest, Romania, Panaitescu Anca Maria ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Filantropia Clinical Hospital, Bucharest, Romania
Published: May 2022

When it has been declared a global epidemic, HIV infection became a challenge for medical world. Even if there is only one healed case cited in literature, treatment for HIV-infection have evolved during time leading to very good results in disease control and limitation of virus transmission. When it comes for viral transmission, an essential research topic became the prevention of mother to fetal transmission. In the long run, many discovered antiretroviral drugs proved to be efficient in controlling HIV infection during pregnancy and thereby in reducing the risk of viral transmission to the fetus. But along with use of the HIV-treatment in pregnancy, many questions have appeared. Are the drugs safe for the fetus, or are there any adverse pregnancy outcomes? Should the treatment be adjusted for the desired results in pregnancy, or should the initial treatment be changed when the pregnancy is diagnosed? Many retrospective or prospective observational studies and comparative studies have been conducted in order to answer those questions and to analyze the efficacy and the safety of mostly used antiretroviral drugs in pregnancy. This article reviews the existing studies, guidelines and recommendations regarding the combined antiretroviral HIV treatment during pregnancy for fetal infection prevention.
Endocrinological disorders in children with cutis-laxa syndromes
Authors:   Research Department, ARTHOPE SRL, Bucharest, Romania, Iancu Mirela Elena ,   Endocrinology Department, Elias Emergency Hospital, Bucharest, Romania, Albu Alice Ioana ,   Endocrinology Department, Elias Emergency Hospital, Bucharest, Romania,   "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania, Vlad Raluca Maria ,   "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania,   "Grigore Alexandrescu" Emergency Children’s Hospital, Bucharest, Romania, Albu Dragos Nicolae ,   "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania
Published: May 2022

Cutis laxa syndromes is a rare, multisystem disorder, which primary involves the skin, caused by various mutations in genes that code structural or functional components of the elastic fiber, resulting in heterogenous manifestations. Diagnosis is primarily based on the physical examination, but supported by molecular tests, and guides treatment and monitoring of the patients. Endocrinological complications are sparsely described, with short stature, osteoporosis and fractures being the most frequent. The precise mechanisms are not elucidated and reports about condition-specific treatments are rare. This review provides an overview of the endocrinological disturbances reported in association with cutis laxa syndromes.
Phenotypic manifestations of C5orf42 pathogenic variants
Authors:   “Dr. Nicolae Robanescu” National Clinical Center for Children’s Neurorehabilitation, Bucharest, Romania, Shelby Elena-Silvia , Cocos Relu ,   Chair of Medical Genetics, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Leanca Madalina Cristina ,   “Dr. Nicolae Robanescu” National Clinical Center for Children’s Neurorehabilitation, Bucharest, Romania, Mirea Andrada ,   “Dr. Nicolae Robanescu” National Clinical Center for Children’s Neurorehabilitation, Bucharest, Romania,   Faculty of Midwifery and Nursing, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Barca Diana ,   “Prof. Dr. Alexandru Obregia” Psychiatry Hospital, Bucharest, Romania
Published: May 2022

Joubert syndrome is a genetic disease with an autosomal-recessive or X-linked inheritance pattern caused by pathogenic variants in at least 35 genes, all encoding structures of the primary cilium involved in signaling pathways that coordinate the normal development of the kidneys, retina, brain, liver and skeletal system. The symptoms can consist in cystic renal disease and renal dystrophy, oculomotor apraxia, global developmental delay, hypotonia evolving into ataxia, skeletal and endocrine abnormalities, abnormal breathing patterns and congenital hepatic fibrosis, with the neurologic and ophthalmologic manifestations appearing early in life. The diagnostic hallmark is “the molar tooth sign”, a malformation of the brainstem and cerebellum easily identifiable using brain imaging techniques. As Joubert syndrome is a highly heterogeneous disease with a large type of phenotypes, it is oftentimes underdiagnosed. This article presents a case of Joubert syndrome type 17, a rare syndrome with many features overlapping orofaciodigital syndrome type VI. Adding to the rarity of this disease, our patient is homozygous and heterozygous for two pathogenic variants in C5orf42, with one located upstream of the other, thus manifesting the phenotype of a compound heterozygous in this gene. We believe that the presentation of this rare syndrome is useful to the pediatric practice by facilitating a fast diagnosis of these patients, which helps provide genetic counselling to the patients and their families.
Enthesitis – a review on the ultrasonographic assessment
Authors:   Department of Rheumatology, University of Medicine and Pharmacy of Craiova, Romania, Dumitrascu Roxana Mihaela , Vreju Florentin Ananu ,   Department of Rheumatology, University of Medicine and Pharmacy of Craiova, Romania, Barbulescu Andreea Lili ,   Department of Pharmacology, University of Medicine and Pharmacy of Craiova, Romania, Trasca Beatrice Andreea ,   Department of Rheumatology, University of Medicine and Pharmacy of Craiova, Romania, Dascalu Rucsandra Cristina ,   Department of Rheumatology, University of Medicine and Pharmacy of Craiova, Romania, Gofita Cristina Elena ,   Department of Rheumatology, University of Medicine and Pharmacy of Craiova, Romania, Ciurea Paulina Lucia ,   Department of Rheumatology, University of Medicine and Pharmacy of Craiova, Romania, Dinescu Stefan Cristian ,   Department of Rheumatology, University of Medicine and Pharmacy of Craiova, Romania
Published: May 2022

The potential benefit gained from ultrasonography examination of the enthesis been extensively studied. Enthesitis plays a key role in pathogenesis of spondyloarthritis and thus, understanding the diagnostic and therapeutic implications has shaped the way clinicians view its importance in clinical practice. The development of high-quality imaging technologies offered a great opportunity to obtain more detailed analysis of the enthesis structure and also differentiate acute from chronic lesions. Several taskforce groups, including OMERACT, highlighted the diagnostic performance of ultrasonography for the detection of enthesitis. Panels of experts have also provided consensus-based definitions of elementary lesions in order to standardize the approach of US-defined enthesitis. Enthesitis is considered one of the main clinical domains in psoriatic arthritis patients and several trials have adopted its use as a potential outcome measure, although research carried out until now, still lacks uniformity between methods used to assess enthesitis. Multiple semiquantitative scoring systems of enthesitis using ultrasonography have been developed in the last two decades and these may provide a more standardized approach in future research.
Where borders meet: Psoriasic arthritis and the cardiovascular risk
Authors:   “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Doca Ana-Maria , Pomirleanu Cristina ,   Rheumatology 2 Department, Clinical Rehabilitation Hospital, Iasi, Romania,   “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Ancuta Codrina ,   Rheumatology 2 Department, Clinical Rehabilitation Hospital, Iasi, Romania,   “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania
Published: May 2022

Objective: We aimed to estimate the long-term global cardiovascular risk (GCVR) in patients with psoriatic arthritis (PsA) and to identify factors correlated with this risk among traditional and non-traditional risk factors. Material and method: Cross-sectional observational study enrolling 45 consecutive patients with PsA without known atherosclerotic disease or heart failure, attending an outpatient rheumatology department over 12 months. Disease-related parameters (clinical phenotype, inflammation tests, type of medication), traditional cardiovascular risk factors (smoking, obesity, dyslipidemia, hypertension, diabetes) and 10-year GCVR (Framingham Heart Study online platform) were collected in all patients according to a predefined protocol. Results: 57.77% of patients were female, with a mean age of 52.1 years; hypertension (46.66%), dyslipidemia and current smoking (20% each) were reported as main traditional cardiovascular risk factors in our cohort. 46.67% patients presented with high cardiovascular risk, 37.78% with intermediate risk, while only 15.55% with low risk. Framingham risk score correlated with coronary atherosclerosis, its sensitivity for the detection of CV risk factors being high (p<0.05). However, no statistically significant correlation was identified between moderate and elevated cardiovascular risk score and lipids, DAPSA score, pain severity and body mass index (p>0.05). Conclusion: Traditional cardiovascular risk factors were reported in a significant proportion of PsA patients, but cannot entirely explain the global cardiovascular risk; additionally, more than half of patients were stratified as having high or intermediate cardiovascular risk. Different factors could interfere with 10-year cardiovascular risk.
Implant rehabilitation with Strategic Implant® technology in two stage implants – bone addition, sinus-lift failure (cases presentation)
Authors:   Evidence & Research Department, International Implant Foundation, Munich, Germany, Fodor Calin Romulus ,   Immediate Loading SRL, Gherla, Romania, Cretu Romana ,   Bonjour Dental Clinic, Cluj-Napoca, Romania, Purghel Teodor ,   CMI Dr. Purghel Teodor, Jibou, Romania
Published: May 2022

In this article, the authors want to present the possibilities of solving some difficult cases, treated in a conventional surgical and implant manner and which were a failure, as well as the possibilities of avoiding these failures using Strategic Implant® technology. In the first case presented, the patient goes through bone augmentation procedures, without reaching the time of implant insertion and prosthesis, with the loss of bone addition on one side of the mandible, the case being later completed with corticobasal implants in immediate prosthetic loading. The second case in which the patient successively loses the inserted two stage implants, without reaching their functional load, resorts to the treatment with corticobasal implants in immediate loading and the fixed prosthetic restoration of the mandible in 3 days postimplantation. The last case in which the patient comes for the removal of a maxillary prosthetic work fixed on 4 two stage implants with bone addition and unilateral sinuslift, with mobility, and in which the treatment with corticobasal implants and fixed prosthetic work in 3 days was the optimal way of treatment. These cases as well as the feedback of the treatment after a number of years show us that the treatment with corticobasal implants can be made much easier using only the native bone of the patient using implants that adapt to the morphology of the existing bone and a immediate loading protocol to allow the optimal functioning of prosthetic works; knowledge of surgical and prosthetic protocols of Strategic Implant® technology lead to predictable prosthetic results with minimally invasive surgery, without sinus lift and bone addition, in a short time of 3 days from the surgical step until the final oral rehabilitation.
The role of periodontal ligament elasticity in periodontal changes - numerical simulation
Authors:   Doctoral School of Dental Medicine “Titu Maiorescu” University, Bucharest, Romania, Capra Andrei , Biclesanu Cornelia ,   Faculty of Dental Medicine “Titu Maiorescu” University, Bucharest, Romania, Buruiana Ana Maria ,   Faculty of Dental Medicine “Titu Maiorescu” University, Bucharest, Romania
Published: May 2022

The clinical applications of oral mucosal biomechanics are particularly important in determining how stimulation can be performed for tissue remodeling, in understanding the level of pressure that can be applied to the painful threshold, in osseous resorption, and the availability of tissue movement. This study shows, through the finite element, the way in which the periodontal ligament behaves at the level of all dental surfaces in nonlinear model and 3 levels of alveolar bone retraction (0 %, 50%, 75%). From the point of view of geometric construction, each model consists of 3 independent components: the alveolar bone, the periodontal ligament (PL) and the tooth. The deformities on the lingual surface are very small compared to the other surfaces. The deformity increases progressively with the loss of the supporting bone. From a physiological point of view, the nonlinear model is much closer to reality because it simulates the reaction of the tissue to its immediate loading by a very low rigidity after which, due to the hydrostatic pressure created in the interstitial fluid, the value of tissue rigidity increases exponentially.
FOSTERING DESTINATION CREATIVITY THROUGH TOURISM LIFESTYLE ENTREPRENEURSHIP: EXPLORING THE MODERATING EFFECT OF FINANCIAL ORIENTATION
Authors: Dias Álvaro , Azambuja Tatiana
Published: May 2022

The motivations and desires of tourists are constantly changing, and in this context, entrepreneurship demonstrates a significant contribution. Especially in the tourism industry, lifestyle entrepreneurs stand out for their contribution not only to the tourism sector, but also by their community attachment. Entrepreneurs with a lifestyle, goals, characteristics, and attitudes are distinct from other entrepreneurs. This research aims to portray the factors influencing their satisfaction with life perception, an important topic to understand their willingness to stay in the community. To this end, a survey was applied to 115 tourism lifestyle entrepreneurs, a data generated was analysed with partial least squares for confirmatory factor analysis. Findings reveal that networking, atmosphere, place attachment positively influence satisfaction with life. Furthermore, findings indicate that the financial objectives moderate these relationships, meaning that the way they conceive and act in their business also influences their satisfaction with life.
Direct Constraints on the Extremely Metal-poor Massive Stars Underlying Nebular C iv Emission from Ultra-deep HST/COS Ultraviolet Spectroscopy
Authors: Senchyna Peter , Stark Daniel P. , Charlot Stéphane , Plat Adele , Chevallard Jacopo , Chen Zuyi , Jones Tucker , Sanders Ryan L. , Rudie Gwen C. , Cooper Thomas J. , Bruzual Gustavo
Published: May 2022

Metal-poor nearby galaxies hosting massive stars have a fundamental role to play in our understanding of both high-redshift galaxies and low-metallicity stellar populations. But while much attention has been focused on their bright nebular gas emission, the massive stars that power it remain challenging to constrain. Here we present exceptionally deep Hubble Space Telescope ultraviolet spectra targeting six local (z < 0.02) galaxies that power strong nebular C iv emission approaching that encountered at z > 6. We find that the strength and spectral profile of the nebular C iv in these new spectra follow a sequence evocative of resonant scattering models, indicating that the hot circumgalactic medium likely plays a key role in regulating C iv escape locally. We constrain the metallicity of the massive stars in each galaxy by fitting the forest of photospheric absorption lines, reporting measurements driven by iron that lie uniformly below 10% solar. Comparison with the gas-phase oxygen abundances reveals evidence for enhancement in O/Fe 2–4 times above solar across the sample, robust to assumptions about the absolute gas-phase metallicity scale. This supports the idea that these local systems are more chemically similar to their primordial high-redshift counterparts than to the bulk of nearby galaxies. Finally, we find significant tension between the strong stellar wind profiles observed and our population synthesis models constrained by the photospheric forest in our highest-quality spectra. This reinforces the need for caution in interpreting wind lines in isolation at high redshift, but also suggests a unique path toward validating fundamental massive star physics at extremely low metallicity with integrated ultraviolet spectra.
A Search for Massive Galaxy Population in a Protocluster of LAEs at z = 2.39 near the Radio Galaxy 53W002
Authors: Yonekura Naoki , Kajisawa Masaru , Hamaguchi Erika , Mawatari Ken , Yamada Toru
Published: May 2022

We searched for massive galaxy population in the known large-scale high-density structure of Lyα emitters (LAEs) at z = 2.39 near the radio galaxy 53W002 by using imaging data from

B
,

V
,

i
′
,

J
,

H
,

and

K

s

bands taken with Suprime-Cam and MOIRCS on the Subaru telescope. We selected 62 protocluster member candidates by their JHK

s
-band colors and spectral energy distribution (SED) fitting analysis (JHK

s
-selected galaxies) in our survey field of

70.2

arcmin

2

and compared their physical properties estimated from the SED fitting with a comparison sample in the COSMOS field. We found significant number density excesses for the JHK

s
-selected galaxies in the 53W002 field at K

s
< 22.25, J − K

s
> 2, or V − K

s
> 4. In particular, the number density of the JHK

s
-selected galaxies with K

s
< 22.25 and J − K

s
> 2 in the 53W002 field is nine times higher than the comparison sample. Most of those with K

s
< 22.25 and J − K

s
> 2 are massive galaxies with M

s
> 1011
M
⊙, and their specific star formation rates (sSFRs) of 10−11–10−10 yr−1 suggest that the star formation has not yet stopped completely. We also found a density excess of quiescent galaxies with M

s
= 5 × 1010
M
⊙ to 1011
M
⊙ and sSFR < 10−11 yr−1, as well as that of low-mass galaxies with M

s
= 109.75–1010
M
⊙ and various sSFRs. The massive galaxies with M

s
> 1011
M
⊙ are not located at the density peaks of LAEs but widely distributed along a similar direction to the structure of LAEs over ∼15–20 comoving Mpc. On the other hand, the quiescent galaxies with sSFR < 10−11 yr−1 clearly avoid the structure of LAEs. Our results suggest that massive galaxies also exist in this protocluster discovered by the moderate overdensity of LAEs and their star formation activities depend on location in the protocluster.
Predicting Solar Energetic Particles Using SDO/HMI Vector Magnetic Data Products and a Bidirectional LSTM Network
Authors: Abduallah Yasser , Jordanova Vania K. , Liu Hao , Li Qin , Wang Jason T. L. , Wang Haimin
Published: May 2022

Solar energetic particles (SEPs) are an essential source of space radiation, and are hazardous for humans in space, spacecraft, and technology in general. In this paper, we propose a deep-learning method, specifically a bidirectional long short-term memory (biLSTM) network, to predict if an active region (AR) would produce an SEP event given that (i) the AR will produce an M- or X-class flare and a coronal mass ejection (CME) associated with the flare, or (ii) the AR will produce an M- or X-class flare regardless of whether or not the flare is associated with a CME. The data samples used in this study are collected from the Geostationary Operational Environmental Satellite's X-ray flare catalogs provided by the National Centers for Environmental Information. We select M- and X-class flares with identified ARs in the catalogs for the period between 2010 and 2021, and find the associations of flares, CMEs, and SEPs in the Space Weather Database of Notifications, Knowledge, Information during the same period. Each data sample contains physical parameters collected from the Helioseismic and Magnetic Imager on board the Solar Dynamics Observatory. Experimental results based on different performance metrics demonstrate that the proposed biLSTM network is better than related machine-learning algorithms for the two SEP prediction tasks studied here. We also discuss extensions of our approach for probabilistic forecasting and calibration with empirical evaluation.
Relationship between Monocarboxylate Transporter-4 Expression and Breast Cancer Clinicopathology and Subtype in Sanglah General Hospital, Denpasar, Indonesia
Authors: Nicolas Gede Andry , Sudarsa I Wayan , Adiputra Putu Anda Tusta , Wihandani Desak Made , Supadmanaba I Gede Putu
Published: May 2022

BACKGROUND: Based on the global cancer observatory (GLOBOCAN) data, in 2018, there were 18.1 million new breast cancer cases. Breast cancer is the second-most common malignancy after lung cancer, which contributed to 11.6% of all new cancer cases in 2018. Breast cancer is the second-leading cause of death in women in developing countries. The activity of Warburg and reverse Warburg effects on breast cancer is reflected by the expression patterns of two molecules, namely caveolin-1 and monocarboxylate transporter-4 (MCT-4). MCT-4 is a transmembrane transport protein that functions in the transport of lactate from the cytoplasm to the intercellular fluid.

METHODS: This is a cross-sectional analytical study to determine the relationship between MCT-4 expression and breast cancer clinicopathology and subtypes. The study was conducted between April and May of 2020 with 62 breast cancer patients as samples in Sanglah General Hospital, Denpasar. Analysis was done with SPSS 25.

RESULTS: A logistic regression analysis was performed to analyze the relationship between the dependent variable (MCT-4) and covariates (stage, grade, and subtype). Of the three variables that were significantly associated with MCT-4 expression, only clinical stage and subtype (luminal and non-luminal) remained independently associated with MCT-4 expression. Analysis on the clinical stage and subtype variables showed an adjusted OR of 4.727 (p = 0.047; 95% CI: 1.109–21.922) and 17.850 (p = 0.009; 95% CI: 2.069–154.003), respectively. This suggests that MCT-4 has a significant association with subtype and clinical stage which increases the risk of progression of the cancer stage as well as the risk of developing a more malignant (non-luminal) subtype.

CONCLUSION: High MCT-4 expression was significantly associated with malignant subtypes, high histological-grade cancer, and an advanced breast cancer.
Chimonobambusa sangzhiensis (Poaceae, Bambusoideae), a new combination supported by morphological and molecular evidence
Authors: Niu Zheng-Yang , Cai Zhuo-Yu , Liao Chun-Lin , Xia Nian-He
Published: May 2022

This study elucidates the taxonomic position of Indosasa sangzhiensis in considering whether it belongs to Indosasa or Chimonobambusa. Based on morphological and molecular phylogenetic evidence, our results explicitly indicated that I. sangzhiensis should be a member of Chimonobambusa, rather than Indosasa, and is a distinct species closely related to C. communis, C. opienensis and C. puberula. Thus, the new combination Chimonobambusa sangzhiensis (B.M.Yang) N.H.Xia & Z.Y.Niu is made. A detailed description as well as two color plates of this species are also provided.
Role Reversal: In-Situ Simulation to Enhance the Value of Interprofessional Team-Based Care
Authors: Muirhead Lisa , Kaplan Barbara , Childs Jennifer , Brevick Indira , Cadet Anne , Ibraheem Muhammad YaQutullah , Kemp LaWanda , Coffee-Dunning Karla , Echt Katharina V.
Published: May 2022

Background:

Effective interprofessional team-based care relies critically on understanding and valuing the role of each team member. Using role reversal with multiple levels of interprofessional education trainees, we developed an in-situ simulation learning experience to enhance team-based care coordination.

Method:

A mixed-methods approach was used to examine participants' readiness, perceived value, and attitude toward interprofessional learning using in-situ simulation in the context of role reversal.

Results:

Data collected to explore the attitudes related to collaboration in solving a complex clinical case revealed that trainees valued the interprofessional educational (IPE) experience, perceived simulation-based learning as conducive to understanding professional roles, and recognized the value of a team-based approach to Veteran-centered care.

Conclusion:

In-situ simulation using role reversal provides a rich and practical approach for IPE implementation where interdisciplinary role appreciation and team-based care can be promoted.

[
J Nurs Educ
. 2022;61(10):595–598.]