bluuebunny/crossref_metadata_2025 huggingface dataset:
Understanding Vitiligo: Causes, Diagnosis, Promising Advances in Treatment and Management and the Impact on Mental Health
Authors: Rama Rao Tadikonda , Sharmeen Hafsa , Tabassum Afshaan , Jasmine Sena Jessy
Published: April 2024

Vitiligo is a chronic skin disorder characterized by the loss of pigmentation, resulting in white patches on the skin. The condition arises from the destruction of melanocytes, the cells responsible for producing melanin, the pigment that gives colour to the skin, hair, and eyes. Although the exact etiology of vitiligo remains elusive, it is believed to involve a complex interplay of genetic, autoimmune, and environmental factors.

This overview provides the key aspects of vitiligo, including its epidemiology, pathogenesis, clinical manifestations, and current treatment approaches. The prevalence of vitiligo varies globally, affecting individuals of all ethnic backgrounds and age groups.

The autoimmune hypothesis proposes that the immune system mistakenly targets and attacks melanocytes, leading to their destruction. Triggering factors, such as oxidative stress, viral infections, and neural factors, may contribute to the initiation and progression of vitiligo.

Clinically, vitiligo can significantly impact the quality of life for affected individuals, both psychologically and socially. The distribution and extent of involvement vary, and the condition can affect any part of the body.

Various treatment modalities are available for vitiligo, ranging from topical corticosteroids and calcineurin inhibitors to phototherapy and surgical interventions. While these approaches may help to re-pigment the skin to some extent, there is no definitive cure, and the outcomes can be unpredictable. Ongoing research is focused on understanding the molecular mechanisms underlying vitiligo and developing targeted therapies to address the root causes of the disease.

Keywords: Vitiligo, Autoimmune, Melanocytes, Pigmentation, Corticosteroids, Quality of life.
Toxic Epidermal Necrolysis: A Case Report to Oral Acyclovir
Authors: Reddy B SathyaNarayana , Molla Alisha , Gohil Chyta Pravin , Patel Nidhi Mayur
Published: April 2024

SJS/TEN is a rare, potentially life threatening, immune-complex-mediated cutaneous adverse drug reaction. Almost one-third of cases are idiopathic. This syndrome is associated with drug treatment as well as infectious agents, neoplasia, and connective tissue diseases. Here we report a 36-year-old male presenting with toxic epidermal necrolysis after 2 days of oral acyclovir.

Keywords: Toxic epidermal necrolysis; Stevens-Johnson Syndrome; acyclovir
Binge drinking and the risks to adolescent health
Authors: Del Ciampo Luiz Antonio , Del Ciampo Ieda Regina Lopes
Published: April 2024

Adolescence is a phase characterized by physical, emotional and social changes that make adolescents more susceptible to risky practices and behaviors. One of these common practices is excessive alcohol consumption, known as “binge drinking”, which causes numerous acute and chronic health problems. This article presents some characteristics observed in adolescent development and the consequences of excessive alcohol consumption for physical and emotional health, and its repercussions on community life.

Keywords: Adolescence, Alcohol, Binge Drinking, Adolescent Health
Hemşirelerin Sosyal Medyada Gelişmeleri Kaçırma Korkusu ile Bakım Davranışları Arasındaki İlişki
Authors: Aydınlı Ayşe , Kaplan Uyan Tuğçe , Ağralı Hatice
Published: April 2024

Amaç: Bu çalışma hemşirelerin gelişmeleri kaçırma korku (FoMO) düzeyleri ile bakım davranışları arasındaki ilişkinin incelenmesi amacıyla yürütüldü.

Yöntem: Tanımlayıcı ve kesitsel tipte yapılan araştırmanın verileri Aralık 2022- Nisan 2023 tarihleri arasında toplandı. Araştırmanın evrenini bir şehir hastanesinde çalışan hemşireler, örneklemini ise araştırmaya katılmayı kabul eden ve dahil edilme kriterlerini sağlayan 270 hemşire oluşturdu. Veriler, “Kişisel Bilgi Formu”, “Gelişmeleri Kaçırma Korkusu Ölçeği” ve “Bakım Davranışları Ölçeği-24” kullanılarak araştırmacılar tarafından toplandı. Verilerin değerlendirilmesinde tanımlayıcı istatistikler, Bağımsız örneklem t-testi, Tek yönlü varyans analizi ve korelasyon kullanılmıştır.

Bulgular: Hemşirelerin gelişmeleri kaçırma korkusu puanının ortalaması 21,70 ±7,389 ve bakım davranışları puanının ortalamaları 5,28 ±0,545 bulundu. Bakım davranışları puanı ile gelişmeleri kaçırma korkusu puanı arasında düşük düzeyde negatif yönde anlamlı doğrusal bir ilişki olduğu görülmüştür (r=-0,174; p<0,01). Ayrıca bakım davranışları bilgi-beceri alt boyutunun puan ortalaması 5,51 ±0,526, güvence alt boyutunun puan ortalaması 5,27 ±0,575, saygılı olma alt boyutunun puan ortalaması 5,23 ±0,615, bağlılık alt boyutunun puan ortalaması ise 5,15 ±0,673 olarak bulunmuştur. 30 yaş altı, bildirimleri kontrol etme sıklığı ve sosyal medya kullanım süresi fazla olan hemşirelerin FoMO düzeyleri daha yüksekti.

Sonuçlar: Bu çalışmada hemşirelerin FoMO puan ortalamalarının orta düzeyde, bakım davranışlarının yüksek düzeyde olduğu söylenebilir. Hemşirelerin sosyal medyada geçirdikleri zamanın artmasının, bakım davranışlarını olumsuz yönde etkilediği belirlenmiştir. Bu doğrultuda hemşirelerin bilinçli bir şekilde akıllı telefon ve sosyal medya kullanımı konusunda farkındalıklarının artırılması önerilir.
ETERMINATION OF THE CYLINDER-BY-CYLINDER POWER OF AN INTERNAL COMBUSTION ENGINE OPERATING IN FREE ACCELERATION MODE
Authors:   Novosibirsk State Agricultural University, Novosibirsk, Russian Federation, KURNOSOV A.F. , GUSKOV YU.A. ,   Novosibirsk State Agricultural University, Novosibirsk, Russian Federation, DOLGUSHIN A.A. ,   Novosibirsk State Agricultural University, Novosibirsk, Russian Federation
Published: April 2024

Efficient operation of transport and technological machines for agricultural purposes is impossible without a timely assessment of the energy performance of their internal combustion engines. The torque and power of each cylinder can be estimated by the magnitude of the reactions of the engine support when operating in free acceleration mode with some of the cylinders disconnected. (Research purpose) The research purpose is improving the method of determining the cylinder-by-cylinder power of an internal combustion engine in the free acceleration mode by the magnitude of the reactions on its supports. (Materials and methods) Developed a methodology for estimating the power of each engine cylinder by the magnitude of the reactions on its supports and the current value of the crankshaft speed. Experimental studies were carried out on a diesel four-cylinder four-stroke engine D-243. During the execution of the research program, the fuel supply to one or two cylinders was gradually turned off, the engine operation mode was set to free acceleration, and forces arising in the supports were recorded using strain gauges and a set of measuring equipment. The following research methods were applied: a priori ranking, regression and computational analysis. (Results and discussion) It was found that the maximum torque is reached in the crankshaft speed range of 1298-1467 revolutions per minute and is 285 nanometers when all cylinders are running, 219 - when three cylinders are running and 148 - when two cylinders are running. The maximum value of the effective power was 57.8 kilowatts for all cylinders, 34 for three cylinders and 22 for two cylinders. It was determined when assessing engine power during the alternate shutdown of one of the cylinders that the effective engine power varies in the range of 33-33.4 kilowatts. (Conclusions) The obtained results of experimental studies can be used in the implementation of a method for operational control of the power of each cylinder of an internal combustion engine under operating conditions.
Simulación de la etapa de recuperación y purificación de dióxido de carbono en la producción de etanol
Authors: Cruz Llerena Arletis , Pérez Ones Osney , Zumalacárregui de Cárdenas Lourdes , Almira Barceló Kendra , Rosales Saborit Diana Rosa
Published: April 2024

La recuperación de dióxido de carbono (CO2) en las destilerías de etanol es un factor importante que aporta beneficios económicos y ambientales. El objetivo de esta investigación fue obtener un modelo de simulación validado para la evaluación de la etapa de recuperación y purificación de CO2 en una destilería cubana. La metodología empleada consistió en obtención y validación del modelo de simulación en Aspen Hysys v.10.0, evaluación de alternativas de mejoras, y realización de un análisis técnico-económico. En el desarrollo de la simulación, se seleccionó NRTL para la estimación de las propiedades para el equilibrio entre el agua y las sustancias orgánicas a bajas presiones en la fase líquida e ideal para la fase vapor. Para el refrigerante, se seleccionó el modelo de Antoine, aplicable para sistemas a bajas presiones y considerando que el comportamiento de la fase líquida es ideal. El modelo de simulación obtenido en el caso base fue validado con los datos reales del proceso con un máximo error relativo inferior al 8 %. Se evaluaron cinco alternativas del ciclo de refrigeración en las que se emplearon nuevos refrigerantes (R-404a, R-290, R-152a, R-600a, R-417a) y se analizó la influencia de las variables de operación en los indicadores de comportamiento del sistema de refrigeración. Desde el punto de vista técnico, la mejor alternativa fue el R-600a, pero en comparación con el caso base, los resultados fueron inferiores. Con el empleo de los nuevos refrigerantes, al rediseñar el ciclo de refrigeración no se obtuvieron rendimientos superiores al 60%.
Improvement of neutropenia in 2 adolescent cases treated with empagliflozin for glycogen storage disease type Ib
Authors: Bae Hyunwoo
Published: April 2024

Neutropenia and elevated concentrations of hepatic transaminases often lead to referrals from emergency or outpatient departments to relevant specialists to diagnose underlying inborn errors of metabolism. Glycogen storage disease type (GSD) Ib, a rare congenital disorder of glucose metabolism caused by the SLC37A4 gene mutations, shows various manifestations, including persistent neutropenia and elevated hepatic transaminases. Empagliflozin has demonstrated its efficacy in treating GSD Ib-associated neutropenia by reducing the entry of 1,5-anhydroglucitol-6-phosphate into the neutrophils. This article reports successful empagliflozin therapy for GSD Ib-related neutropenia in 2 Korean adolescents. Diagnosing GSD Ib is complex and usually initiated by a referral from emergency or outpatient departments when there is a high index of suspicion. Once diagnosed, empagliflozin shows promising outcomes in restoring counts and function of the neutrophils without severe adverse effects in children with GSD Ib, supporting it as a safe and effective therapeutic option for GSD Ib-associated neutropenia.
Driving sustainable financial management: An investigation of factors influencing the use of digitals technologies by MSMEs
Authors: Ramayanti Rizka , Rachmawati Nurul Aisyah , Setiawan Rudi , Azhar Zubir
Published: April 2024

Following the rapid growth of technology, accounting information systems are also expanding. It is now possible to digitally generate financial reports or records that are part of an accounting information system using specific software. A financial accounting application can fully, rapidly, accurately, and comprehensively automate bookkeeping (Putri, Amrulloh, et al., 2023; Mahardhika, 2019). This study examines the impact of usefulness, ease of use, and compliance on the actual use of financial apps using a methodology based on the Technology Acceptance Model (TAM). Google Forms were utilized to conduct an online survey for data collection. The research sample consisted of 123 participants. The respondents are Indonesian micro, small, and medium-sized companies (MSMEs). This investigation employs a structural equation model (SEM). The study’s findings indicate that ease of use and compliance have a favourable and significant impact on the actual use of financial applications. In the meantime, usefulness benefits finances but is irrelevant to the application’s real use. Thus, it is possible to conclude that these findings help elevate the significance of MSME perspectives about using financial reports apps. In terms of applying financial reports applications, the research concludes with findings that can significantly influence and pave the path to a sustainable future.
Displacement of occluder after left atrial appendage closure（LAAC）:A case report
Authors: Mao Xiaobo , Lin Yan
Published: April 2024

The efficacy and safety of left atrial appendage occlusion (LAAO) in
preventing non valvular atrial fibrillation stroke have been confirmed
by multiple randomized controlled and registered studies,and have been
recommended by several guidelines for stroke prevention in patients with
atrial fibrillation at high risk of stroke.We reported an 80-year- old
male
Acumulación de sólidos, un aspecto crítico en los sistemas acuícolas intensivos: alternativas para una gestión sostenible
Authors: Chaverra-Garcés Sara Cristina
Published: April 2024

La mantención de la calidad del agua en los sistemas intensivos de producción acuícola se ha convertido en un desafío a la hora de cumplir con criterios desostenibilidad. Uno de los principales problemas que enfrenta la acuicultura actual se encuentra relacionado con la rápida acumulación de residuos sólidos y compuestos inorgánicos. A continuación se presenta una revisión actualizada sobre estrategias que están siendo implementadas para mitigar el impacto generado por la acumulación de desechos orgánicos e inorgánicos en sistemas cerrados intensivos tipo RAS y tecnología biofloc (BFT) con miras a fortalecer la economía circular en la industria acuícola. Dentro de las tecnologías ambientalmente adecuadas se destaca el papel de los microorganismos como agentes biorremediadores, especialmente la acción de bacterias amonio y nitrito oxidantes así como de bacterias fotosintéticas. Del mismo modo, la incorporación de bacilos y poliquetos ha demostrado tener éxito en el manejo de sedimentos. Por su parte, los sistemas multitróficos que integran diversas especies acuáticas de gran valor nutricional y comercial como algas, moluscos, crustáceos y equinodermos también han obtenido resultados exitosos en la gestión sostenible de efluentes. En el caso de los efluentes de origen marino se ha propuesto la integración con plantas halófitas del género Sarcocornia cuyos usos han sido promisorios y tienen potencial en la industria agrícola y de biocombustibles. A pesar de los recientes avances en la implementación de estas tecnologías alternativas aún hace falta mayor investigación relacionada con la aplicación a mayor escala, mecanismos de acción de los biorremediadores, valorización de los procesos, evaluación del ciclo de vida, sostenibilidad y resiliencia en los sistemas acuícolas intensivos. Asimismo es preciso fortalecer el apoyo entre entidades del sector acuícola y ambiental para lograr un mayor impacto en la disminución de la contaminación y la gestión sostenible de los recursos naturales.
Elliptic Quaternion and Elliptic linear Interpolation
Authors: Rahebi Melisa , Yaylı Yusuf
Published: April 2024

Spherical spline quaternion interpolation has been done on sphere in Euclidean space using quaternions. In this paper, we have been done elliptic quaternion linear interpolation on ellipsoid using elliptic quaternions. This interpolation curve is called Elerp elliptic linear interpolation. In addition, ESquad (spline elliptic quaternion interpolation) is defined by using the group structure feature of elliptic quaternion on ellipsoid.
Mutual Images of Romanians and Hungarians in Proverbs Collected in the Nineteenth Century
Authors: MITU Sorin
Published: April 2024

This article analyzes Romanian and Hungarian proverbs collected in the nineteenth century that convey images of the Other. These were published mostly in the masive collections of proverbs, sayings, and riddles edited by András Dugonics, Ede Margalits, and Iuliu Zanne. Proverbs speak first of all about the differences between “us” and “them,” about the negative traits of those around us, by which we identify ourselves and which highlight our superiority and “normality” in relation to dangerous and peculiar strangers around us. Peasants did not reflect on their neighbours in order to outline an objective portrait of them, but to display and reinforce their own cultural features, setting themselves apart from the strangers surrounding them. For this reason, they usually mocked and did not praise the Other. Mockery and ridicule were much more common than positive assessments, regardless of whether the relations between the two communities were good or bad. In this general framework, the popular images of the two peasant communities were agreeable and conveyed a sense of closeness and familiarity rather than a high degree of otherness, as was the case with the imagological relationships maintained with the Gypsies or the Jews.
Rezumat. Acest articol analizează proverbe româneşti şi maghiare culese în secolul al XIX-lea care transmit imagini ale celuilalt. Acestea au fost publicate în mare parte în colecţiile masive de proverbe, zicători şi ghicitori editate de András Dugonics, Ede Margalits şi Iuliu Zanne. Proverbele vorbesc în primul rând despre diferenţele dintre „noi” şi „ei”, despre trăsăturile negative ale celor din jurul nostru, prin care ne identificăm şi care ne evidenţiază superioritatea şi „normalitatea” în raport cu străinii periculoşi şi ciudaţi din jurul nostru. Ţăranii nu reflectau asupra vecinilor lor pentru a contura un portret obiectiv al acestora, ci pentru a-şi etala şi întări propriile trăsături culturale, deosebindu-se de străinii din jurul lor. Din acest motiv, de obicei i-au batjocorit şi nu l-au lăudat pe Celălalt. Batjocura şi ridicolul erau mult mai frecvente decât aprecierile pozitive, indiferent dacă relaţiile dintre cele două comunităţi erau bune sau rele. În acest cadru general, imaginile populare ale celor două comunităţi ţărăneşti erau agreabile şi transmiteau un sentiment de apropiere şi familiaritate mai degrabă decât un grad ridicat de alteritate, aşa cum era cazul relaţiilor imagologice întreţinute cu ţiganii sau cu evreii.
Cuvinte-cheie: Români, Maghiari, proverbe, secolul al XIX-lea, imagologie istorică
Article: history; Received: 19.02.2023; Revised: 03.11.2023 Accepted: 17.12.2023; Available online: 30.01.2024
Journalist, Spy, Propagandist: About Vándory Lajos and His Activity in Romania (1876–1885)
Authors: GHENGHEA Mircea-Cristian
Published: April 2024

Towards the end of the 19th century, the relations between Austria-Hungary and Romania experienced several delicate episodes, caused by the diametrically opposed interests of the two sides regarding the specific realities of South-Eastern Europe. The rulers in Vienna and especially those in Budapest could only see the Romanian state as an obstacle to their plans, and therefore tried to quickly learn and decipher the diplomatic and political intentions and initiatives of the Romanian decision-makers. On different occasions, in order to obtain the necessary information, they resorted to setting up and supporting networks of influencers, propagandists and spies, both in Transylvania and across the Carpathians. The present article aims to add details to the depiction of an interesting figure, Vándory Lajos, who, according to the press of the time and several archival documents, was one of those who operated within the territory of the Romanian state as a spy, under the cover of working as a journalist. At various times, by his actions, he contributed to the further straining of the already problematic Romanian-Hungarian relations.
Rezumat: Spre sfârşitul secolului al XIX-lea, relaţiile dintre Austro-Ungaria şi România au cunoscut mai multe episoade delicate, provocate de interesele diametral opuse ale celor două părţi cu privire la realităţile specifice sud-estului Europei. Conducătorii de la Viena şi mai ales de la Budapesta nu puteau vedea în statul român decât un obstacol în calea planurilor lor, încercând, în consecinţă, să cunoască şi să descifreze cât mai repede intenţiile şi iniţiativele diplomatice şi politice ale factorilor decidenţi din România. Pentru obţinerea informaţiilor necesare, au făcut apel în diverse rânduri la constituirea şi sprijinirea unor reţele de agenţi de influenţă, propagandişti şi spioni, atât în Transilvania, cât şi peste Carpaţi. Prin intermediul textului nostru, încercăm să contribuim la completarea imaginii unui interesant personaj, Vándory Lajos, care, aşa cum arată presa vremii şi documentele de arhivă, a fost unul din cei care au activat pe teritoriul statului român în calitate de spion, sub acoperirea îndeletnicirii de gazetar. În diferite momente, prin acţiunile sale, a contribuit la tensionarea suplimentară a relaţiilor româno-maghiare, oricum problematice.
Cuvinte-cheie: Vándory Lajos, relaţii româno-maghiare, presă, propagandă, spionaj.
Article: history; Received: 08.10.2023; Revised: 30.10.2023 Accepted: 01.11.2023; Available online: 30.01.2024
A Review of Generations X and Y’ Work Values and Attitudes Across North America and Europe
Authors: NEGRUȘA Adina Letiția
Published: April 2024

The Generational Theory, on the other hand, has been used uniformly in numerous studies without taking into account the historical, social, and cultural variations from one place to another. Because Generation X, and Millennials are currently the most significant generational cohorts for the employment market, this study aims to investigate from a historical perspective the fundamental and work value, leadership styles, and work attitudes of these generations, taking into account regional differences between the North America and European nations. The review indicates that an increasing number of studies have adopted the assumption that, regardless differences in social and economic situations of different nations, generational cohorts have the same patterns and biases. The research conducted in this article contributes to enhancing the approach of generational theory in organizational behaviors studies and highlighting the idea of stark disparities across various areas and nations based on various historical occurrences.
Article history: Received: February 22, 2024; Reviewed: March 10, 2024; Accepted: March 25, 2024; Available online: March 29, 2024.
JEL classification: N30, J10.
Pets In Advertising or How to Influence Consumers?
Authors: KULCSÁR Erika , HARMATI Anikó
Published: April 2024

Animals have always played an important role in the history of humanity. We only have to think of prehistoric cave paintings, or the relationship between our grandparents and animals, or recall the iconic films Alpha or Hachi, A Dog’s Tale. However, it is important to note that the nature of the relationship between animals and humans has changed over time. Whereas in the past their relationship was mainly characterised by respect: maintaining their personal independence; nowadays this relationship has taken on a different dimension, as pets – in most families – live in the same household, receiving the same level of attention as the rest of the family. The primary objectives of this study are (1) to identify the product/service categories that are not targeted at dogs and pets, but they appear as the primary communicators in the promotion of the product or service, (2) to identify the characteristics that fundamentally define this type of advertising.
Article history: Received: November 22, 2023; Reviewed: February 2, 2024; Accepted: March 7, 2024; Available online: March 29, 2024.
JEL classification: M37.
La investigación participativa en proyectos de diseño
Authors: Mejía Modesto Beatriz Irene , Hernández García Montserrat Paola , Zizumbo Alamilla Alda María
Published: April 2024

This document exposes the characteristics, origins, objectives and stages of the participatory research methodology, placing it as a research methodology applied mainly in the fields of social sciences. Seeking to contribute to the change in mentality that is required today, in terms of what the designer’s task should be and his way of designing, focusing on the real needs of people. The benefit of integrating participatory research and participatory design in projects is raised, especially those with a community intervention approach. Projects are exposed in which this methodology has been applied, community participation has been achieved, laying the foundations of community empowerment.
Collagen derived from a giant African snail (Achatina achatina) for biomedical applications
Authors: Pomary Dustin , Korkor Belinda Selase , Asimeng Bernard Owusu , Katu Solomon Kingsley , Paemka Lily , Apalangya Vitus Atanga. , Mensah Bismark , Foster E. Johan , Tiburu Elvis K.
Published: April 2024

Achatina achatina (AA) is a rich source of collagen due to its large size, but it is underutilized. Type I collagen was extracted from AA to serve as an alternative to existing collagen sources. The collagen was extracted at varying alkaline and temperature conditions to determine the optimal parameters that would give a high yield of acid-soluble collagen. The extracted collagen was characterised using X-ray diffraction, Fourier transform infrared (FTIR) spectrometry, thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC) to confirm the integrity and purity of the extracted collagen. The type of collagen was determined using sodium dodecyl sulphate-polyacrylamide gel electrophoresis. The α-1, α-2, and dimer electrophoresis bands confirmed that the collagen is type I, and the XRD data supported the findings. The highest collagen yield was obtained at 4 ℃ for 48 h, which decreased with increasing temperature due to the instability of the protein in acid at high temperatures. A cytotoxicity test was conducted using an Alamar blue assay. The AA collagen-treated normal prostate cell line (PNT2) showed no significant difference from the untreated control cells. The high-quality type I collagen extracted from AA has the potential for biomedical and other industrial applications.
Development of an Advanced Control Algorithm for DAB DC/DC Converters: Inrush Current Limitation and Enhanced Operation in Transient States.
Authors: Bachman Serafin , Turzyński Marek
Published: April 2024

The publication addresses the dynamic state challenges encountered during development of a Dual Active Bridge (DAB) converter within DC microgrid systems. The conventional startup method is identified as instigating a cascade of unfavorable outcomes, encompassing elevated starting current, transformer current asymmetry, DC voltage distortions, EMI and heightened thermal stress on semiconductor components. Additionally, it necessitates precise calibration of magnetic components and diodes. A proposed remedy to these issues is introduced, involving a control method based on an additional phase shift to modulate the current of the primary H bridge. This novel control methodology is posited as a means to mitigate the aforementioned undesirable effects associated with traditional converter initiation techniques. The research also delves into considerations of proper design procedure for the converter. Emphasis is placed on integrating the novel control methodology into the design framework to effectively address challenges arising during transient states. Validation of the proposed solution is substantiated through a series of laboratory tests, the results of which are comprehensively presented in the article. These tests affirm the efficiency of the system when incorporating the novel control methodology, thereby substantiating its practical utility in mitigating the identified issues during the initiation phase of the DAB converter in DC microgrid systems.
The effect of coating process thermal cycle on mechanical properties of AA6061-T6 used for load-carrying elements of a space instrument: a case study
Authors: Barciński Tomasz , Kosturek Robert , Kowalski Tomasz , Bzowski Maciej , Wawrzaszek Roman , Mostowy Karol , Baran Jędrzej , Daukszo Maciej
Published: April 2024

Components used for the structure of the GLObal Solar Wind Structure experiment in the NASA Interstellar Mapping and Acceleration Probe space mission, made of AA6061-T6 alloy, are subjected to the coating process, where the temperature affects its mechanical properties. The aim of this paper is to examine the impact of the coating thermal cycle on the mechanical properties of AA6061-T6 alloy, which is the load-carrying material in a spaceborne instrument. As a part of the manufacturing process, the parts made of AA6061-T6 are subjected to a coating process at a temperature of about 220°C for a time longer than 1h. This treatment modifies the mechanical properties of the alloy. To evaluate the consequences of this change for spaceborne components, mechanical testing and numerical simulation were carried out. It was found that as a result of the coating process, the reduction in AA6061-T6 yield strength is about 16%, which entails a decrease in the margins of safety by 25% at its maximum.
Radiographic identification of challenging gastrointestinal tract foreign bodies: a descriptive study of how appearance varies in air versus water to aid interpretation
Authors: Yuen Franco , Dennison Sophie
Published: April 2024

OBJECTIVE

To provide veterinarians with updated radiographic descriptions of select radiolucent foreign material in a simulated gastrointestinal environment.

SAMPLE

368 veterinarian respondents from the US.

METHODS

An online survey was administered between June 18, 2023, and July 2, 2023, through a private veterinarian-based social media group. Representative commonly ingested foreign bodies were radiographed surrounded by air and water to simulate being within the gastrointestinal tract. Two examiners evaluated and qualified the opacity of the objects for each environment.

RESULTS

The private social media group had a total of 3,900 members including veterinarians from all disciplines. A total of 362 small animal veterinarians (9.3% of the group) responded to the study reporting a total of 123 foreign objects that were not causing mechanical obstruction at the time of initial presentation. Sixty-eight foreign bodies were reported greater than or equal to 5 times and grouped as balls (n = 4), food (9), fabric (14), wood (3), soft plastic (14), hard plastic (18), or other (6). Most (98.5% [67/68]) objects were easily identifiable in air. In water, 23.5% (16/68) of the objects were obscured, and 39.7% (27/68) had inversion of the major opacity when compared to the opacity in air.

CLINICAL RELEVANCE

The opacity of some ingested radiolucent material can invert relative to air or fluid, which may reflect substantial differences in detection following repositioning. When known dietary indiscretion occurs, radiographing a sample of the material in air and water will improve the accuracy of assessment.
Immunotherapy with genetically engineered T cells holds promise for the treatment of nonmalignant diseases in the dog
Authors: Mason Nicola J.
Published: April 2024

The ability to genetically redirect the antigenic specificity of T cells using chimeric antigen receptors (CAR) has led to unprecedented durable clinical remissions in human patients with relapsed/refractory hematological malignancies. This remarkable advance in successful immune cell engineering has now led to investigations into the application of CAR–T-cell technology to treat nonmalignant diseases. The use of CAR-T cells to target and eliminate specific cell subsets involved in the pathogenesis of autoimmunity, fibrosis, senescence, and infectious disease represents a new direction for adoptive cell therapies. While the use of CAR-T cells for nonmalignant disease is still in its infancy, early reports of dramatic clinical responses to CAR-T cells targeting CD19+ B cells in patients with severe autoimmune disease raise the possibility that this approach could lead to durable remissions, eliminating the need for ongoing conventional immunosuppressive therapies. Excitingly, nonmalignant disease processes that may be addressed by CAR–T-cell therapy in humans also occur in our canine populations. Given that technologies for developing canine CAR constructs are now available, robust protocols have been described for generating canine CAR-T cells, and experience is being gathered with their clinical use in oncology, it is anticipated that CAR-T cells will soon enter the veterinary clinics for the treatment of debilitating nonmalignant diseases. Here, we provide a broad overview of CAR–T-cell therapies for nonmalignant diseases and extrapolate these advances into the veterinary space, highlighting areas in which canine CAR-T cells are poised to enter the clinics for the treatment of nonmalignant disease.
Abundant 2480 Ma Detrital Zircons in ∼1740 Ma Vishnu Schist in Northwestern Arizona: Derivation From the Matachewan Large Igneous Province?
Authors: Spencer Jon E. , Doe Michael F. , Domanik Kenneth J.
Published: April 2024

Detrital zircon grains in the ∼1740–1750 Ma Vishnu Schist and similar rock units in northwestern Arizona consist of up to 30% grains dated by U-Pb isotopic analysis at 2470–2490 Ma. These zircon grains are distributed over ∼40,000 km2 and define an age peak at 2480.0 ± 27.3 Ma (2SE). These grains have yielded unusually consistent 207Pb/206Pb dates, with generally smaller analytical uncertainty and greater concordance to ideal U-Pb evolution than grains of other ages. A weighted mean age of 2480 ± 0.9 Ma (2SE) for this zircon population reflects consistent analytical results and high analytical precision but not the accuracy of the age. The source of these zircons has not been identified. To better characterize the unidentified source, we analyzed 45 of these grains for trace and rare-earth elements by laser-ablation mass spectrometry and scanned 16 grains with an electron microprobe to identify mineral inclusions. Mass spectrometer determinations of Sc/Yb and Nb/Sc support derivation from an oceanic-island igneous source. Electron microprobe scans revealed quartz in 5 of 16 grains, indicating a felsic source. The low variability in 207Pb/206Pb dates and a generally linear relationship between U and Th support zircon derivation from a single igneous unit or closely related set of units without xenocrystic zircons. A literature search for other zircon populations with similar age and U/Th ratios identified ∼2480 Ma zircons in a Mesoproterozoic(?) metapsammite and conglomerate in southwestern Montana. This sandstone was deposited near the margin of the Wyoming craton and contains almost entirely 2400–3600 Ma zircons, unlike zircon grains in Vishnu Schist which include a large population of 1730–1900 Ma zircons. From this relationship we infer that the 2480 Ma zircons in both areas were derived from a source in the Wyoming craton. We conclude that the 2480 Ma Vishnu zircons were derived from a felsic batholith that formed above and from hotspot magma related to the ∼2450–2480 Ma Matachewan Large Igneous Province, that this batholith formed by mixing between a mantle-derived hotspot magma and assimilated Archean continental crust, and that the source rock was emplaced during initial rifting between the Wyoming craton and the Superior province.
Spatiality of Human Visceral Leishmaniasis in Maranhão, Brazil
Authors: Silva Danielle Pereira Costa , Périco Eduardo , Silveira Eliane Fraga da , Schröder Nádia Teresinha
Published: April 2024

Objective: the study analyzed the spatio-temporal and epidemiological behavior of HVL in the state of Maranhão, between 2010 and 2020.
 
Theoretical framework: In Brasil, HVL is one of several diseases with compulsory notification, and is registered in 21 Federation Units, establishing itself in the five Brasilian regions. The Northeast region has the highest number of recorded cases, considered a focus of transmission of the disease, with Maranhão being one of the states with the highest occurrence.
 
Method: the study used secondary data from the Notifiable Diseases Information System. The incidence rate, lethality rate, mortality rate, Odds Ratio and Annual Increment Rate were calculated.
 
Results and conclusions: pointed to an endemic scenario of the disease. The predominant profile was male, aged between 1 and 9 years old, brown color/race, primary education and urban residence area. It is necessary to monitor the environment where vectors are present to control them and reduce the possibility of illness.
 
Implications: the study is relevant as it contributes with epidemiological data and health indicators from an endemic region, so that health authorities can implement surveillance actions, health education and carry out public health interventions respecting socioeconomic differences and local environmental.
 
Novelty: the identification of areas at risk for the disease in a given region allows us to know their spatiality, the population's chances of becoming ill and the rate of increase in the disease.
The Moderating Role of Reader Characteristics on E-Book Reading Intention in Thailand: A Multigroup Analysis
Authors: Sinchawarnwat Thipsuda , Pankham Sumaman
Published: April 2024

Purpose: This investigation explores the moderating role of reader characteristics in shaping individuals' intentions to engage in e-book reading in Thailand.
 
Theoretical Framework: Drawing upon a diverse sample of readers in Thailand, this analysis employs advanced statistical techniques to assess the moderating effects of reader characteristics, including sex, age, education level, income, and devices used to read e-books.
 
Design/methodology/approach: Utilizing a quantitative approach, the study analyzes responses from 701 Thai people who have engaged with a minimum of five e-books to understand the moderating role of reader characteristics on e-book reading intention in Thailand.
 
Findings: The results from the structural equation model analysis showed that several factors in the proposed model had a significant influence on intention to read e-books. These factors include trust, diversity of e-book options, social norms, and resource usage.
 
Practical implications: The results that come from this investigation contribute to the growing body of literature on digital reading behavior and offer practical implications for stakeholders in the publishing sector and government organizations that promote reading. By comprehending how reader characteristics moderate the factors influencing e-book reading intentions, tailored strategies can be developed to promote digital literacy and enhance the adoption of e-books in the Thai market. As the global landscape of reading continues to evolve, this research offers a precious viewpoint to explore the intricate interplay between individual characteristics and the digital reading experience in Thailand.
 
Originality/value: Limited research has examined the moderating influence of reader characteristics on the intention to read e-books. Therefore, this study seeks to address this gap in the existing literature by conducting a multigroup analysis in the context of Thailand.
An Exploration of Demographic Characteristics Concerning Accommodation Choice Behavior of Tourists in Luong Prabang, Lao PDR
Authors: Putachote Nitipon , Chokpiriyawat Thanuset
Published: April 2024

Introduction: The lodging industry plays a crucial role in the tourism sector, with tourists' choices influenced by various factors, including demographic characteristics. Understanding how demographic factors impact tourists' lodging preferences is essential for effective marketing strategies. This study investigates the relationship between tourists' demographic characteristics and their lodging choice behaviors in Luang Prabang, Lao PDR.
 
Methodology: Data were collected from 390 tourists using surveys conducted in Luang Prabang. Demographic characteristics examined include gender, age, education, occupation, country of origin, and income. Lodging choice behaviors analyzed encompass lodging, staying duration, room type, transportation, room cost, and spending cost. The Chi-square statistical method was employed to analyze the data.
 
Results: The analysis revealed significant associations between tourists' demographic characteristics and their lodging choice behaviors. Gender was found to influence lodging preferences, with differences observed in the choice of hotel size, staying duration, and booking methods among different age groups. These findings underscore the importance of considering demographic factors in marketing strategies within the hotel industry.
 
Discussion: The study highlights the relevance of demographic segmentation in understanding and catering to tourists' diverse lodging preferences. By tailoring marketing strategies to specific demographic profiles, businesses can better meet the needs and preferences of different tourist segments. Additionally, the findings contribute to existing literature on the role of demographic factors in shaping tourists' lodging choices.
Economic and Financial Viability of Pig Farming in the Integrated Termination System
Authors: Krüger Silvana Dalmutt , Bergamin Welington , Souto Adriana Morales Alencar , Zanin Antonio
Published: April 2024

Objective: The study aims to compare the economic and financial viability of expanding the pig farming activity carried out in the finishing system, on a rural property in the municipality of Xavantina/SC.
 
Search method: Methodologically, the research is descriptive, carried out through a case study and qualitative analysis. From the collection of data relating to batches from the period 2019 and 2020, a statement of the results of the pig farming activity was prepared. Discounted payback, Internal Rate of Return (IRR) and Net Present Value (NPV) were used for analysis.
 
Main results: Economic results demonstrate the net margin per batch of pigs of up to 64% in the current finishing system. With the increase in investments, the net margin is up to 44% per lot. The results show a financial return time of 10 years, 11 months and 8 days, with an IRR of 10.08% in the current situation. Considering the investments in expanding the new piggery and the revenue and expense projections, the financial return will occur in 18 years, 11 months and 8 days, with the IRR at 10.02%. In general, the results demonstrate the importance of rural accounting as a support instrument in monitoring activities developed to support the economic-financial analysis of investments and the decision-making process.
Innovation and Sustainable Public Budget Under the Aegis of The Triple Bottom Line (Tbl) And the Sustainable Development Goals (SDGs)
Authors: Silva Maria Valesca Damásio de Carvalho , Silva Marcelo Santana , Pereira Aliger dos Santos
Published: April 2024

Objective: to identify how the public budgets of the municipalities of the Metropolitan Region of Salvador-RMS are committed to the Triple Bottom Line (TBL) and the Sustainable Development Goals (SDGs), highlighting the innovative proposal to analyze them.
 
Theoretical Framework: Innovation has become the "order of the day" in the public sector. In addition to its role as a promoter through the private sector, creating an innovation ecosystem and delivering it to companies, the public sector has been seeking to make important innovations in the modus faciendi in its internal management from its budget. The articulation of government planning and the new paradigm of TBL and SDGs in public management needs to become a reality, a practice that is considered as an organizational innovation based on the planning and analysis of public budgets.
 
Method: Use a deductive and qualitative approach of exploratory nature, with statistical treatment, idealization and calculation of the "Indicator of the Dimension of Expenditures in the Budget" (IDGO) for the economic, environmental and social dimensions of the 13 municipalities of the Metropolitan Region of Salvador – RMS-BA.
 
Results and Conclusion: The results indicated that there is a preponderance of the social IDGO to the detriment of the economic and environmental IDGOs in the budgets studied. and that, particularly the environmental dimension, needs more attention in budget allocation.
 
Research Implications: From this analysis proposal for a sustainable public budget, municipal public managers can innovate in their management from reallocations and more careful planning of budgets, allocating financial resources in a more balanced way.
El fundamento lingüístico de la lectura
Authors: Bastidas Alfonso
Published: April 2024

Resumen
Adquisición del lenguaje y desarrollo del conocimiento
Authors: Baena Luis A.
Published: April 2024

Resumen
Consideraciones sicolingüísticas sobre la lectura en una segunda lengua
Authors: Navarrete Antonio , Villa Tito
Published: April 2024

Resumen
Characterization of the key distinguishing features of a digital platform as a business model
Authors: Nikolaev Pavel Viktorovich
Published: April 2024

The purpose of the study is to identify the most characteristic features of the business model of the digital platform and further compare them with the empirical experience gained in the analysis of the Yandex.Market company. The objectives of the study include determining the main characteristics of the digital platform as a business model, analyzing Yandex.Market, its core business, competitive advantages, and environment, as well as identifying the correspondence between the company's business model and previously established key features of the digital platform and analyzing the advantages that participants receive from interacting with the platform. The object of the study is the main factors of change and further business development under the influence of digital transformation. The subject of the study is the key features of the digital platform's business model in the Russian market, using the example of Yandex.Market. To achieve the goals of the research, theoretical methods such as literature analysis, studying interviews with business experts, synthesizing new knowledge based on them, conducting modeling, and empirical methods such as the method of expert assessments, experiment and observation of the company's activities. The importance of using digital technologies are now recognized by all participants in both the business and scientific community. This contributes to the emergence of a large number of studies devoted to this topic. So this work is aimed at identifying those features that are inherent in one of the most effective business models of our time, namely the digital platform. Considering the experience of Yandex.Market makes the work especially relevant for Russia. The scientific novelty of the work consists in identifying unique features inherent only in the business model of a digital platform using the example of one of the Russian platform companies. The work also examines in detail the experience of Yandex.Market and the key advantages that make the platform company one of the most successful in the Russian market.