bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficient and simultaneous immobilization of fluoride and lead in water and tea garden soil by bayberry tannin foam loaded zirconium
Authors: Huang Xiaolu , Zhang Mei , Wang Minghui , Wen Zhuoyu , Jiang Yamei , Sui Yunhao , Li Xiaoting , Ma Jun , Liao Yang
Published: May 2023

Human activities have led to various pollution in the environment, and the combined pollution of fluoride and lead in acidic tea garden soil has received much attention. The key to eliminating this combined pollution is to immobilize pollutants simultaneously, thus preventing their migration from tea garden soil to tea trees. In this paper, the natural product bayberry tannin was employed as raw material to fabricate functional materials (TF-Zr) for simultaneous adsorption of fluorine (F) and lead (Pb) in water and soil by the reactivity of tannin with Pb2+ and the affinity of Zr with F. The characterization techniques such as SEM-Mapping, EDS, FT-IR, XPS were utilized to probe the adsorption mechanism. The results showed that TF-Zr could simultaneously and efficiently adsorb F− and Pb2+ with the adsorption capacity of 5.02 mg/g (Pb) and 4.55 mg/g (F), and the adsorption processes were both in accordance with the proposed secondary kinetic adsorption model. Besides, the presence of F− promoted the adsorption of Pb2+ by TF-Zr. The materials were applied into the tea garden soil to explore its effect on the variation of F and Pb forms in tea garden soil. It was found that the proportion of water-soluble fluorine, exchangeable fluorine and exchangeable lead in the tea garden soil decreased significantly, while the proportion of residual fluorine and residual lead increased evidently, illustrating TF-Zr possessed eximious fixation effect on the highly reactive fluorine and lead in the soil and facilitated their conversion to the more stable residue state. Therefore, TF-Zr can be used for the efficient and simultaneous immobilization of fluorine and lead in water and tea garden soil.
The effect of tDCS on mind wandering in adults with and without ADHD:
Authors: Nejati Vahid , Majidinezhad Maryam , Yavari Fateme , Nitsche Michael
Published: May 2023

Objective Individuals with attention deficit- hyperactivity disorder (ADHD) have a higher propensity to mind wandering. The ventromedial prefrontal cortex (vmPFC) and dorsolateral prefrontal cortex (dlPFC), which show reduced functionality in individuals with ADHD, are involved in mind wandering.Methods Forty adults with or without ADHD received transcranial direct current stimulation (tDCS) in three different conditions including anodal left dlPFC/cathodal right vmPFC stimulation, the reversed montage, and a sham stimulation. During stimulation, in each session, participants performed the sustained attention to response task as a measure of attentional performance, and a task-unrelated thoughts task to monitor mind wandering.Results A significant main effect of stimulation condition was identified for attentional performance and task-unrelated thoughts. Anodal left dlPFC coupled with cathodal right vmPFC stimulation improved attention task performance and reduced mind wandering. Furthermore, higher baseline mind wandering and ADHD scores independent from the diagnostic group were associated with larger beneficial effects of tDCS on mind wandering.Conclusion These results described the role of the left dlPFC and the right vmPFC on attentional performance and mind wandering in adults with and without ADHD. tDCS had beneficial effects on mind wandering, and attention with simultaneous anodal left dlPFC and cathodal right vmPFC stimulation, and the size of the effects on mind wandering depended on mind wandering before intervention, and ADHD scores.
Bioassay-guided purification of α-glucosidase inhibitor fatty acids from Padina tetrastromatica
Authors: Moheimanian Nioofar , Mirkhani Hossein , Edraki Najmeh , Poustforoosh Alireza , Momeni Safieh , Khalighian Najmeh , Zidorn Christian , Sohrabipour Jelveh , Jassbi Amir Reza
Published: May 2023

Anti-diabetic potential of a brown alga, Padina tetrastromatica, from the coastline of the Persian Gulf, using bioassay-guided purification approach yielded the most active α-glucosidase inhibitor agents as fatty acids. Initially, the yeast’s α-glucosidase inhibition of the MeOH and 80% MeOH extracts were evaluated via a colorimetric assay. The liquid-liquid fractionation of 80% MeOH extract, as the most potent α-glucosidase inhibitor, resulted in four fractions, n-hexane, ethyl acetate, n-butanol and water. Hexane and ethyl acetate fractions were selected for further studies, with the IC50 values of 38.0 ± 0.3 µg/mL and 53.7 ± 2.6 µg/mL, respectively. Followed by investigating α-glucosidase inhibition of the sub-fractions from the hexane fraction, using flash column chromatography, F18-21 selected as the most potent enzyme inhibitor. After further purifications of F18-21 by semi preparative HPLC, the mentioned fraction and two purified compounds, 8-octadecenoic acid (8) and all-cis-5,8,11,14-eicosatetraenoic acid (10) were subjected to GC-MS analysis for the identification. In addition, 1D and 2D NMR evaluations were performed for characterisation of 8-octadecenoic acid. Furthermore, three fatty acids, all-cis-8,11,14,17-eicosatetraenoic acid (6), cis-9,12-octadecadienoic acid (7), and all-cis-5,8,11,14,17-eicosapentaenoic acid (11), were isolated from the ethyl acetate fraction and identified, by HPLC and GC-MS techniques, respectively. Finally, α-glucosidase inhibition percent of the purified fatty acids were evaluated in two concentrations in the microplates, which showed their great potential for further investigations as anti-diabetic agents, in comparison with acarbose, as the positive control. Furthermore, molecular docking analysis and MD simulation were applied to investigate the structure activity of the purified compounds.
Multi-Stimuli-Responsive Biocompatible Magnetic Nanocarrier as Drug delivery System to MC7 Breast Cancer Cells
Authors: Ehsanimehr Sedigheh , Moghadam Peyman Najafi , Dehaen Wim , Shafiei-Irannejad Vahid
Published: May 2023

Efforts are ongoing to develop effective controlled-release therapeutic systems through innovative functional targeted drug delivery systems (TDDS). Functional polymeric nanocarriers are crucial in delivering therapeutic drugs efficiently into tumors. This study designed a redox/pH-responsive functional drug delivery platform with ligands for targeting MC7 breast cancer cells using a core-shell biocompatible magnetic nanocarrier. The process involved synthesizing oleic acid-coated Fe3O4@SiO2 nanoparticles, modifying pluronic F127 (PF 127) with maleic anhydride and aminating it to form PF127-NH2, linking L-cysteine to PF127-NH2, and condensing carboxymethyl-β-cyclodextrin (CM-β-CD) to PF127-NH2/L-cysteine, which was targeted by folic acid (FA). The resulting PF127-NH2/L-cysteine-CM-β-CD-FA formed LCMNPs-SS in the presence of oleic acid-coated Fe3O4@SiO2. Doxorubicin (DOX) was used as a model drug and loaded into the LCMNPs-SS nanocarrier. The LCMNPs-SS nanocarrier exhibited excellent properties for controlled release, with release rate and level controllable by adding an external magnet and adjusting the DTT concentration. Additionally, the LCMNPs-SS nanocarrier could disassemble under the effects of oxidant or pH, allowing for fine-tuning of drug release in response to temperature and pH or multiple stimuli.
Nivolumab after cyclophosphamide and doxorubicin induction chemotherapy in previously treated patients with EGFR or ALK wild type non-squamous cell non-small cell lung cancer with less than 10% of PD-L1 expression
Authors: AHN Beung Chul , Park Charny , Lee Sang-Jin , Hong Sehwa , Hwang Ji-Eun , Kwon KyoungSuk , Kim Kyung-Hee , Kim Hyae Young , Lee Geon Kook , Lee Youngjoo , Han Ji-Youn
Published: May 2023

Purpose
To investigate whether cyclophosphamide (C) and adriamycin (A) induction therapy (IT) prior to nivolumab could enhance the efficacy of nivolumab in previously treated patients with non-squamous (NSQ) non–small-cell lung cancer (NSCLC) with less than 10% PD-L1 expression.
Methods
Patients received four cycles of CA-IT (C,500 mg/m2 and D, 50 mg/m2) every 3weeks. Nivolumab was given 360 mg every 3 weeks from the second cycle. After 4 cycles of CA-IT, nivolumab 480 mg was administered every 4 weeks. We collected blood samples for next-generation sequencing, fluorescence-activated Cell Sorting (FACS) to characterize immune cells, and liquid chromatography-tandem mass spectrometry to identify potential biomarkers.
Results
A total of 22 patients were enrolled. The median progression-free and overall survivals were 2.4 months (95% CI, 1.3–3.5) and 11.6 months (95% CI, 5.3–18.0), respectively. Two patients with a partial response received nivolumab for 2 years without disease progression. FACS revealed the lowest ratio of myeloid-derived suppressor cells (MDSCs) to CD8 + T-cell throughout the treatment in responders. Proteomic analysis identified a consistent upregulation of extracellular matrix-receptor interactions and phagosome pathways in the responders. Among the differentially expressed proteins, the transferrin receptor protein (TRFC), which mediates ferroptosis and phagocytosis, was higher in responders than in non-responders before treatment.
Conclusions
CA-IT did not improve nivolumab efficacy in NSQ-NSCLCs with low PD-L1 expression. However, CA-IT induced deceasing MDSC resulted in durable response. Higher baseline TRFC levels may predict favorable response to nivolumab in NSCLC with low PD-L1 expression.
Trial Registration: NCT03808480
Serum uric acid predicts progression of islet beta cell function decline in female patients with type 2 diabetes mellitus
Authors: Li Minchao , Li Nan , Wu Haidi , Lou Qinglin , Yu Jiangyi , Gu Liubao , Huang Liji
Published: May 2023

Background: It remains controversial whether serum uric acid (SUA) level can predict beta cell function decline in patients with type 2 diabetes mellitus. The present study aims to investigate the association between baseline SUA levels and longitudinal islet beta cell changes in a cohort of Chinese type 2 diabetes patients.
Methods: In the present single-center longitudinal retrospective study, 473 type 2 diabetes patients who received standard 75g oral glucose tolerance test (OGTT) and insulin release test both at baseline and after follow-up were included. Beta cell function was assessed using the homeostasis model. Cox hazards regression analysis was used to evaluate the association between levels of SUA and decline of beta cell function.
Results: At baseline, patients with higher SUA levels had higher triglyceride level (p=0.000), higher BMI (p=0.003), higher level of HbA1c (p=0.000) and HOMA-B (p=0.000). In contrast, during follow-up, a higher annual rate of decline in beta cell function (RHOMA-B) was found in females with the highest uric acid than patients with lower uric acid (p=0.017), but not in males (p=0.494). In addition, a positive correlation was observed between SUA and RHOMA-B in total (r=0.103, p=0.043) and in females (r=0.192, p=0.032). SUA levels were not correlated to RHOMA-B in males throughout. Consistently, multivariate analysis revealed that HOMA-IR (p=0.025) was the only one independent predictor of beta cell function decline in males, whereas elevated SUA (p=0.008) and age (p=0.009) were independently associated with longitudinal beta cell function impairment independently of potential confounders in females.
Conclusions: An independent positive association between SUA and long-term beta cell function decline was demonstrated in female patients with type 2 diabetes, but not in males. A potential close association and interaction among uric acid metabolism, sexual hormones, and insulin secretion capability might exist in type 2 diabetes patients.
Enhancing the antimicrobial sensitivity of Staphylococcus aureus with herbal extracts as an adjunctive treatment for reversing antibiotic resistance
Authors: Do Anh Duy , Van Thach Phan , Nguyen Thi-Phuong , Bui Le Minh
Published: May 2023

Background and aim:
Staphylococcus aureus is a significant public health concern due to its ability to develop antibiotic resistance. Biofilm formation or the enhancement of bacterial cell membrane permeability contributes to antibiotic resistance ability. Herbal therapy presents a promising strategy to overcome antibiotic resistance challenges. This study aims to investigate the potential of herbal extracts to reverse antibiotic resistance in S. aureus.
Experimental Procedure:
In this study, both Wild-type and Kanamycin-adapted (Km-adapted) S. aureus strains were pre-treated with herbal extracts derived from Zingiber zerumbet (ZZ), Eucalyptus globulus (EG), Andrographis paniculata (AP), Clerodendrum inerme(CI), Combretum quadrangular (CQ), and Plectranthus amboinicus (PA) at subinhibitory concentrations. The effects of these extracts on biofilm formation, bacterial cell surface hydrophobicity, cell permeability, and kanamycin sensitivity on pre-treated S. aureus were evaluated.
Results:
Our results demonstrated that S. aureus formed thick biofilms that were less sensitive to Km treatment, particularly in Km-adapted strains. However, extracts from ZZ, EG, and AP effectively reduced biofilm formation in both wild-type and Km-adapted strains and decreased bacterial cell surface hydrophobicity. Additionally, all herbal extracts increased the permeability of S. aureus cells, resulting in enhanced antibiotic sensitivity.
Conclusion:
Herbal therapy has the potential to reverse antibiotic resistance and reduce the necessary antibiotic dosage for treating S. aureus-related infections.
Impact of GSM-EMW exposure on the markers of oxidative stress in fetal rat liver
Authors: Salameh Mariam , Zeitoun-Ghandour Sukaina , Sabra Lina , Daher Ahmad , Khalil Mahmoud , Joumaa Wissam H.
Published: May 2023

The current study investigated the effects of 24 hours/day prenatal exposure to global system for mobile communication electromagnetic fields (GSM-EMFs), 900 MHZ-induced electromagnetic radiation (EMR), on oxidative stress (OS) status, apoptotic, and inflammatory changes in liver of rats during their fetal development period. Fifty-two Sprague-Dawley pregnant rats were equally divided into control and exposed groups. Whole embryos were removed at 7.5 dpc (days post coitus), while liver tissues were extracted from embryos at 11.5, 15.5, and 19.5 dpc. For exposed animals, results showed an increased OS reflected by high levels of malondialdehyde (MDA), a decrease in cytosolic superoxide dismutase (cytoSOD) activity, in mitochondrial superoxide dismutase (mitoSOD) levels and catalase (CAT) mRNA expression but also in hepatic nuclear factor erythroïd 2-related Factor 2 (Nrf-2), protein kinase B (Akt1), and intercellular adhesion molecule-1 (ICAM-1) mRNA expression at 15.5 dpc. Moreover, GSM-EMR exposure was shown to significantly decrease mitoSOD and CAT activities at almost all studied ages. Thus, rat embryos may be protected by their mothers from OS, apoptotic, and pro-inflammatory responses till a sensitive developmental stage, during a continuous prenatal EMR exposure. This protection could be then created from the embryos themselves.
Formation of Agshell/Aucore Bimetallic Nanoparticles by Pulsed Laser Ablation and Chemical Reduction Methods: The Effect Green Laser Wavelength and Colloidal/Solution Concentration
Authors: Mohebi Elham , AdibAmini Shaghayegh , Sari Amir Hossein , Dorranian Davoud
Published: May 2023

The main purpose of this experimental research is to study the effects of different silver concentrations on the optical properties of bimetallic Agshell/Aucore nanoparticles. The gold nanoparticles are ablated by the PLAL technique of the gold target on the bottom of the container. The container is filled with colloidal silver nanoparticles and manufactured by chemical reduction. The colloidal solution of mixed nanoparticles is irradiated by the second harmonic of the pulsed laser Nd:YAG laser at 532 nm wavelength. The peak absorption of gold nanoparticles around 530 nm is used to transfer laser energy to nanoparticles and synthesis the Agshell/Aucore bimetallic nanoparticles. The volumetric ratio of nanoparticle solutions are the experimental variables. Bimetallic nanoparticles are distinguished by the following: X-ray diffraction pattern (XRD), spectroscopy in the range of UV-Vis-NIR and IR, Dynamic light scattering (DLS), Energy Dispersive Spectroscopy (EDS), Photoluminescence spectrum (PL) and, Fourier transform infrared spectroscopy (FT-IR). In addition, FE-SEM and TEM images are used to investigate nanoparticle size and morphology. One of the objectives of this research is the preparation of stable bimetallic systems and the study of optical properties, in order to check the reactivity of silver nanoparticles in the bimetallic system. Moreover, the shell thickness and catalytic properties of bimetallic structure with a different silver concentration is discussed. The following, dipole mode is shown in the visible area for every samples and quadrupole mode is not detected in sample with high silver concentration.
Production of Domestic Utensils Using Waste Polyethylene Terephthalate (Pet) Bottle Caps Without the AID of Industrial Machines
Authors: ICHETAONYE SIMON
Published: May 2023

This study presents the production of domestic utensils using waste PET bottle caps without the aid of industrial machines. This aims to explore the feasibility of recycling waste PET bottle caps as raw materials for domestic utensils, such as cups and bowls, to reduce waste and provide an eco-friendly alternative to traditional (industrial-made) plastic utensils. This study lies in its approach to utilizing waste PET caps, which are typically not recycled due to their small size and low value. Additionally, the increasing amount of plastic waste and the need for sustainable solutions to reduce it has always been a factor. Although, several types of research have been carried out on the use of waste PET bottles/caps as a reinforcement for construction materials, sustainable textiles, and solid fuel, little to on research is reported on using waste PET bottle caps for the production of domestic utensils. Experimental tests were conducted to determine the physical and mechanical attributes of the domestic utensils, which include water absorption, hardness, compressive strength, and drop test. The test analysis shows that the domestic utensils for waste PET bottle caps reveal comparable and optimal physical and mechanical properties compared to the traditional plastic utensils. The waste PET bottle caps utensils (cup and bowl) sample recorded a minimal water absorption rate of 0 %, maximum hardness, and compressive strength value of 74 and 90 HV; 69 and 87 N/mm2, respectively. Thus, this suggests that waste PET bottle caps can be recycled into domestic utensils with promising results since it presents a practical solution that can contribute to more sustainable future, a viable solution that addresses both environmental problems and the need for sustainable alternatives to traditional plastic utensils.
A hybrid model based on Discrete wavelet prediction (DWT), Bidirectional recurrent neural networks to wind speed prediction
Authors: Barjasteh Arezoo , Ghafouri Seyyed Hamid , Hashemipour Malihe
Published: May 2023

Wind speed is the main driver of wind power output, but its inherent fluctuations and deviations present significant challenges for power system security and power quality. Accurate short-term wind power forecasting is necessary to ensure the stability and integration of wind energy into the grid. Non-stationarity is a major challenge in analyzing wind speed data, and change-point detection are essential for optimal resource allocation. This paper addresses the issue of short-term wind power forecasting for stable and effective wind energy system operation. To predict non-stationary data and detect change points, non-stationary data must first be transformed into stationary data. Discrete wavelet transformation (DWT) is used to decompose wind speed traces into low- and high-frequency components for more accurate predictions using deep learning algorithms. The proposed approach uses a Gated Recurrent Unit (GRU) network, which has a concise network structure and requires less computational load, making it suitable for quickly predicting short-term and long-term dependencies in wind speed data. Experiments demonstrate that the proposed method outperforms other cutting-edge methods in terms of prediction accuracy.
Autophagic degradation of CDK4 is responsible for G0/G1 cell cycle arrest in NVP-BEZ235-treated neuroblastoma
Authors: Liu Zhen , Wang Xiao–Yang , Wang Han-Wei , Liu Shan-Ling , Zhang Chao , Guo Ying , Gao Feng-Hou
Published: May 2023

CDK4 is highly expressed and correlated with poor prognosis and decreased survival in advanced NB. Seeking a regimen that selectively targets CDK4 degradation is a potentially promising therapeutic strategy relative to conventional CDK4 inhibitors.In this work, we determined that autophagy as a new pathway for the degradation of CDK4. Firstly, autophagic degradation of CDK4 is critical for NVP-BEZ235-induced G0/G1 arrest and growth inhibition via the blockade of autophagy-related gene Beclin1. Secondly, we observed the first evidence that the p62 binds to CDK4 and then enter autophagolysosome to degradate CDK4 in a CTSB-dependent manner in NVP-BEZ235 treated NB cells. Analogous results regarding the interaction p62 with CDK4 were observed in NVP-BEZ235 treated neuroblastoma xenograft mouse model. These results not only established the pivotal role of the autophagy pathway in CDK4 turnover but also suggest the potential application of NVP-BEZ235 or other drugs via the therapeutic modulation of autophagic degradation of CDK4 protein in NB.
Assessment of awareness and knowledge of Syrian Private University students about ophthalmoplastic surgical procedures
Authors: Almouselli Alaa , Alrwaili Ammar , Salman Afraa
Published: May 2023

Background There was a gap in the literature regarding the knowledge of healthcare professionals, including medical students, about eye plastic surgery. In this study, we aimed to assess the perception and knowledge among medical students about ophthalmic plastic surgery.Methods A cross-sectional study was conducted at the Syrian Private University through a questionnaire designed by the professor supervising the research. The questionnaire was distributed between medical students, from the first to the sixth year. 501 male and female students participated in the study. Data collected from 30 September 2022 to 30 November 2022. All participants were informed of the study requirements and those who agreed to participate were enrolled.Results The study included 501 medical students, and females represented more than half of the sample, 286 (57.1%), compared to males 215 (42.9%). Predominant age group was (21–25 years) 338 (67.5%). for the academic stage, the fourth year accounted for the largest percentage, 132 (26.3%). We found that a small percentage of the students had previously undergone ocular plastic surgery 30 (6%). Most of students answered that they do not want to become a specialist in ophthalmic plastic surgery 277 (55.3%). More than half of the students answered that ophthalmic plastic surgery is high risk 259 (51.7%). We found that females 23 (8%) had previously undergone surgery at a greater rate than males 7 (3.3%). Regarding the areas of ophthalmic plastic surgery, it was found that there was a low awareness among students about the types of these operations, while it was found that they had good awareness about cases that could be treated through ophthalmic plastic surgery. As for the students’ source of information, the largest percentage of study at the university was 271 (25.1%).Conclusion The study showed that medical students lack appropriate knowledge about eye plastic surgery, and this may have contributed to their lack of interest in engaging in this specialty in the future.
Comprehensive characterization of the effect of mineralocorticoid receptor antagonism with spironolactone on the renin-angiotensin-aldosterone system in healthy dogs.
Authors: Masters Allison K , Ward Jessica L , Guillot Emilie , Domenig Oliver , Yuan Lingnan , Mochel Jonathan P
Published: May 2023

Objective –
To characterize the dose-exposure-response effect of spironolactone on biomarkers of the classical and alternative arms of the renin-angiotensin-aldosterone system (RAAS) in healthy dogs.
Animals –
Ten healthy purpose-bred Beagle dogs.
Procedures –
Study dogs were randomly allocated to 2 spironolactone dosing groups (2 mg/kg PO q24hr, 4 mg/kg PO q24hr). The dogs received 7-day courses of spironolactone followed by a 14-day washout period in a crossover (AB/BA) design. Angiotensin peptides and aldosterone were measured in serum using equilibrium analysis, and plasma canrenone and 7-α-thiomethyl spironolactone (TMS) were quantified via liquid chromatography-mass spectrometry/mass spectroscopy (LC-MS/MS). Study results were compared before and after dosing and between groups.
Results –
Following spironolactone treatment, dogs had a significant increase in serum aldosterone concentration (P = 0.07), with no statistical differences between dosing groups. Significant increases in angiotensin II (P = 0.09), angiotensin I (P = 0.08), angiotensin 1–5 (P = 0.08), and a surrogate marker for plasma renin activity (P = 0.06) were detected compared to baseline following spironolactone treatment during the second treatment period only. Overall, changes from baseline did not significantly differ between spironolactone dosages. RAAS analytes were weakly correlated (R < 0.4) with spironolactone dosage and plasma canrenone or plasma TMS. There were no adverse clinical or biochemical effects seen at any spironolactone dosage during treatment.
Conclusions –
Treatment with spironolactone increased serum aldosterone concentration in healthy dogs and impacted other biomarkers of the classical and alternative arms of the RAAS. There was no difference in effect on the RAAS between 2 and 4 mg/kg/day dosing. Dosage of 4 mg/kg/day was safe and well-tolerated in healthy dogs.
Mathematical modeling of the heat transfer process in a dense blown layer of granular material
Authors: Boshkova Irina , Mukminov Ihor
Published: May 2023

The object of research: a mathematical model of unsteady heat transfer between particles forming a dense layer in a heat exchange channel and an air flow passing through the layer.

Investigated problem: obtaining a mathematical model adequate to the physical phenomenon will significantly expand the field of research, reduce the time for determining the thermal characteristics of heat transfer and data processing.

The main scientific results: an explicit analytical dependence is obtained that allows calculating the local temperature of the layer in an arbitrary cross-section of the channel at selected moments of time. The presented analytical dependence was verified by analyzing the calculated data on the material temperatures in the channel obtained by varying the main physical quantities: the effect of the heating duration, heat transfer coefficient, porosity, and density on the temperature distribution was studied. The temperatures along the length of the channel were calculated at different points in time with the following initial data: material - gravel: c=860, ρ=1500, λ=0.6, ε=0.4; aud=800. Based on the results of the calculations for the time τ=60 s, τ=900 s, τ=1800 s, τ=2400 s, τ=1800 s, the graphs shown in the paper are constructed. It is shown that the mathematical model adequately describes the process of heating a layer of granular material in a heat exchange channel and allows obtaining satisfactory data on the temperature distribution along the length at different points in time. The calculated data correlate satisfactorily with the experimental results.

Innovative technological product is an analytical dependence obtained for the first time, which is necessary for inclusion in the calculation method of regenerative heat exchangers intended for the utilization of low-potential heat flows.

The area of practical use of the research results is the heat engineering calculations of regenerative heat exchangers with a dense granular packing. The consumers of the developed regenerators are greenhouses and food industry. Such industries are characterized by a low-potential level of thermal emissions, the heat of which is difficult to utilize using existing heat exchange equipment.

Scope of the innovative product: design bureaus focused on the design of innovative heat exchangers for the utilization of low-potential heat flows, and research laboratories studying the processes of heat exchange between a dense layer of granular material and a through gas (air) flow.
Development of a new type of household appliances – refrigerators with a heating chamber
Authors: Titlov Oleksandr , Hratii Tetiana
Published: May 2023

The object of this study is absorption-type refrigeration appliances, which allow to expand the functionality of household appliances without additional energy consumption.

Investigated problem: The aim of this study: firstly, due to the novelty of the proposed technique, it was necessary to show the real possibility of obtaining the temperature level required for technological processes (up to 70 °C); secondly, taking into account the experience gained in experimental studies, it was necessary to propose new designs for solving the problems of refrigeration and heat treatment of food products and raw materials in domestic conditions.

The main scientific results: It is shown that the development of devices that combine the functions of refrigeration storage and heat treatment of food products, semi-finished products and agricultural raw materials can become a promising area for energy saving in household appliances. In such household combined appliances, the heat released during the implementation of the refrigeration cycle is not immediately removed to the environment, but is transferred to a special heating chamber, while the temperature in the volume of the heating chamber is maintained higher than the air temperature in the room. The effect of energy saving is achieved by expanding the functionality of household appliances without attracting additional energy costs.

The original designs of combined absorption-type household appliances are proposed, a description of their operation, advantages and disadvantages, and areas of application are given.

The area of practical use of the research results: In the course of experimental studies, it was shown that the introduction of an additional heating chamber into the structure of household absorption refrigerators, thermally connected with the lifting section by the dephlegmator of the absorption refrigeration unit, does not lead to an increase in energy consumption (according to the test results below than in the standard version by 5 %) and does not impair the performance of the cooling chambers.

The area of practical use of the research results: household energy-saving appliances.

Innovative technological product: the use of an evaporation-condensation cycle that provides highly efficient heat transfer at a distance of up to 1 meter from the heat dissipation zone of the refrigeration unit to the usable volume of the heating chamber of the household appliance.
Ukrainian dual use export control evolution: historical pickles
Authors: Kartuzov Egor
Published: May 2023

A prime object of this effort was to evaluate the premises of appearance and historical evolution of export control and transfer of dual use (DU) technologies emerged in Ukraine after 1991.

Investigated problem: Liquidation of Soviet's monopoly on foreign trade in 1990s, a change in relations between the state and commodity producers, and a massive entry of unprepared exporters chasing maximum profits into the world market could not be envisaged in a full swing at that time by young and unexperienced Ukrainian export control system. The paper looks into Ukrainian DU technology transfer (TT) through a prism of historical premises. Those premises have been formed and are still found standing amongst technology offeror/end user and other TT players. Needless to say, that a technology transfer is a complicated, multi-leveled and multi-players process being impacted and followed with few factors and historically pre-set conditions that constrain its success or failure at the end. The development of DU technologies continues in a quagmire of conflicting interests, the ongoing war in Ukraine, national security and export control rationales.

For the time being, debates on Ukrainian DU technologies and their misuse so far lack creativity and rather blurred; political and diplomatic initiatives came finally to nowhere trying to find turnkey solutions, all this is quite a challenge nowadays.

The results of this analytical endeavor make a further solid floor for further debates in terms of politics, legislation and export control
Trends in the development of the processing of melons and gourds
Authors: Alimardanova Mariam , Tlevlessova Dinara , Syzdykova Laila , Karlygash Abdieva , Petrenko Yelena , Brindyukova Alexandra
Published: May 2023

The review of equipment for processing and technology of processing melons and gourds is given. Primary processing of gourds has not been industrialized in the CIS countries and abroad until recent years. Theoretical prerequisites for the creation of products based on melon are presented, the issues of rational use of melon for the production of long-term storage products are highlighted. The main physical-mechanical and rheological properties of pumpkin, melon and watermelon fruits are given. The proposed options for equipment and technological lines for the processing of watermelon, melon, pumpkin fruits are presented. The technologies for processing the fruits of watermelon and melon are described.

The object of research: Melons and gourds, namely processing technology

Investigated problem: Imperfect technologies for processing melon fruits.

The main scientific results: systematization of data on the problem of processing melon fruits for food in order to choose a rational way to improve processing technologies.

The area of practical use of the research results: The bottom line is the developed technologies

Innovative technological product: technology for processing gourds.

Scope of the technological innovative product: food industry (Food production).
El ciclón “YAKU” * en la historia peruana
Authors: Deza Rivasplata Jaime
Published: May 2023

En la naturaleza no existen fenómenos, todo tiene un ritmo que por millones de años ha formado al planeta y la vida en la biósfera; pero el hombre lo desconoce, he ahí su tragedia. Nada es inmutable. Todo cambia a consecuencia de una serie de factores que reaccionan en cadena: Movimientos de inclinación, balanceo, precesión, enfriamiento y calentamiento terrestre, corrientes marinas de acercamiento e influencia periódica que inciden en la ontogénesis(*) de las especies, vientos, lluvias, climas… todos constituyen las fuerzas normativas de evolución en la biósfera. Los ríos secos, lagos, lagunas, humedales, albuferas, chorrillos, tienen un proceso, un ritmo que los activa, que se evidencia también en ríos subterráneos, estratos hídricos, filtraciones a través de las cuales escurre el agua de lluvias intensas al mar.
Influence of general government expenditure on the development of sports entrepreneurship: The case of some OECD countries
Authors: Nazarov Vugar , Kalantarly Nailya , Hajiyev Jamal , Hasanova Gulnar , Hashimova Albina
Published: May 2023

The low level of the nation’s health and physical activity highlights the need to find additional mechanisms for the development of the sports sphere, one of which is to increase its financing. This paper aims to investigate how an increase in general government expenditure on recreation and sports affects sports entrepreneurship (turnover or gross premium written in the sports industry; value added at factor cost of sports enterprises; sports industry market size) and the share of the population involved in sports (as an indicator characterizing the development of sports). The study used the panel unit root test and fixed and random effects models. Modeling proved that the increase in general government expenditure on recreation and sports by 1% largely determines the increase in value added at factor cost of sports enterprises (by 5.48%). A significantly less effect is for turnover or gross premium written in the sports industry (by 0.85%), and the smallest is for the sports industry market size (by 0.4%). A 1% increase in general government expenditure on recreation and sport has the greatest impact in the Czech Republic (by 2.37%) and Slovakia (by 2.44%) and the least – in Australia (by 0.4%). The share of the population involved in sports is almost independent of general government expenditure on recreation and sports in all 10 OECD countries.
Imperative of Request of Indonesian and Japanese Language
Authors: Rachman Zulfikar
Published: May 2023

The research aimed to find the imperative of requests and their politeness in the Indonesian and Japanese languages. It also aimed to analyze the similarities and dissimilarities between both languages. The method applied in the research was comparative studies. The data on both languages were collected from novels, movie dialogue, email, questionnaires, SNS (LINE, WhatsApp, Instagram, Facebook), and daily conversation corpus. As a result, the request markers "tolong" and "mohon" change an imperative into requesting expression. "Boleh" and "bisa" are necessary to construct an interrogative imperative of request. On the other hand, in the Japanese language, there are onkei hyōgen (~te kureru/~te kudasaru/~te morau/~te itadakeru) and ganbō hyōgen (~tai, ~te hoshii). It also has positive (masu), negative (nai/masen), assertive (masuka/desuka), and tentative (deshōka) forms. In the Indonesian and Japanese languages, commanding has the lowest politeness, followed by requesting expression. The permission request is the politest. Also, the imperative of request shows modesty and does not strongly force the audience. The imperative of request in the Indonesian language is a command that got request markers "tolong" and "mohon" to soften the command intention. On the contrary, the Japanese separate the imperative of command and request forms.
Discovering the Prosodic Domain of Aceh Hakka Tone Sandhi
Authors: Lee Johnny , Ling Wang-Chen
Published: May 2023

The research investigated the tonal system of the Hakka dialect spoken in the Aceh province of Indonesia. The aim of the research was twofold. First, it retranscribed the dialect’s tonal inventory and provided a comparison with Meixian Hakka and the inventory found in Chen’s (2007) research. Second, it analyzed the Shang Tone Sandhi Rule (STSR) of the dialect and its prosodic domain. The data were collected with a careful design based on the number of syllables, different prosodic structures, and a variety of tonal combinations. The data were collected from two informants, who were female Hakka native speakers that originated from Banda Aceh, Indonesia. The research used mainly an impressionistic approach with some support from Praat Version 6.2.14 to evaluate the pitch of the tones. As for the research’s transcription, the researchers opt for the simpler yet phonologically distinct three-level height system (H, M, L) rather than the five-pitch category of Chao. The research identifies that there are six tonal values in this dialect. The tonal alternation rule, i.e., STSR, operates in a multisyllabic domain, and only the tone at the end of a domain is intact from tonal alternation. The STSR is not sensitive to the syntactic domain c-command relation of the Direct Reference Hypothesis. It also behaves differently compared to the Guangxing dialect Yangping Tone Sandhi Rule. As for prosody, the hierarchical domain of the rule in Aceh Hakka is bounded within the Utterance (U), which is different from the Yinping tone sandhi domain in Meinong Hakka, in which tone sandhi is blocked by the I domain (intonational phrase domain). Therefore, the researchers postulate that the domain for Aceh Hakka Shang tone sandhi lies in the Utterance (U).
The Correlation between Student’s Perception and Comprehension Achievement of the English Language Derivational Morphology
Authors: Bunau Eusabinus
Published: May 2023

The research investigated the correlation between the perception and achievement of the students of English language derivational morphology comprehension. The perception was what was claimed, and the achievement was what was gained. There were primary and secondary data in the research. The primary data were collected by survey, and the secondary data were taken from the mid-test score record documented in the Academic Information System. The survey was implemented by distributing 18 questionnaire statements to 62 respondent students enrolling in English Morphology class. The non-parametric data resulted from the Likert Scale of 1 to 4 options. The perception was interpreted using the index percentage equation, and the interval of percentage was 25. Moreover, the achievement was calculated using the mean score equation. The Pearson Product Moment formula was applied to compute the correlation between perception and achievement. It is revealed that the students’ perception index on the English language derivational morphology is 52,53%, falling into the criteria of 50,01%-75,00% with the category of ‘I get it’. Furthermore, the mean score of student achievement is 76,45 and is categorized as ‘good’, placing in the range of 70,00-79,99. The research concludes that the null hypothesis is accepted, and the perception does not correlate linearly with the achievement of the comprehension of the English language derivational morphology. The correlation coefficient is -0,04365, and the category of the correlation is negligible. Despite the correlation and its category, this research infers that the perception is understandable, and comprehension is achievable.
Analysis of Regional Budget Management Performance at Regional Finance Agency of Pamekasan Regency
Authors: Kamaroellah R. Agoes , Syafik Moh.
Published: May 2023

The research aimed to analyze the performance of regional income, expenditure budget, and budget performance of revenue and expenditure at the Regional Finance Board of Pamekasan Regency during 2013-2016. In this descriptive quantitative research, data source was the Regional Expenditure's financial performance by considering the Budget Realization Report's information (Laporan Realisasi Anggaran/LRA). The analysis involved a three-step analysis, variance analysis, growth of regional expenditure, and suitability analysis of regional expenditure. The research reveals that most of the periods studied experience more expected differences, amplified with the target budget realization revenue from 2013-2016 has an average rate of 100,05%. The degree of decentralization of Kabupaten Pamekasan shows an average of 24,16%, which is considered below the percentage criteria of Original Local Government Revenue (OLGR) to Total Revenue Area (Total Pendapatan Daerah/TPD) ranging from 0,00-10,00%. Revenue Financial Performance District Pamekasan experiences an increase in Financial Performance Revenue, which is indicated by a positive growth rate of 8,29%. The level of dependency of Pamekasan Regency in 2013-2016 is very high, indicated by the average Local Financial Dependency Ratio above 50%. The results suggest that there is a dependence of the Pamekasan Government on central government or provincial government. The surplus occurs due to the intensification and extensification of original local growth revenue in the form of taxes, levies, and other income.
Abnormal Return Analysis Before and After General Election in Asia
Authors: Lesmana Steven , Sumani Sumani
Published: May 2023

The research aimed to examine the capital market`s reaction to political events as seen from the abnormal return using the event study concept. Since there are conflicting results of similar previous studies, further research is needed. The research used event study methods, cumulative average abnormal return (CAAR) to compare abnormal returns during the general election. The research intended to compare stock market activities where there are general elections in four countries in Asia which conduct general elections every five years, and with the condition that the general elections in those countries must be completed within one day. The calculation was carried out on the stock index`s daily data representing the country in the last five events general elections in each country. The research used an estimated period of 120 days and a time of observation of 33 days. Research shows no significant difference between the average abnormal returns before and after the general election event in the last five events for all the countries tested. It can occur due to various factors, such as the anticipation made by investors, investors' behavior, and the amount and speed of information circulating. Further research is required to find out the form of the country`s efficient market.
Role of Threshold of Free Shipping Promotion and Product Type on Impulsive Buying Behaviour in E-Commerce Platform
Authors: Yendola Readdy Aria , Windasari Nila Armelia
Published: May 2023

The research proposed a new insight on how the threshold of free shipping (TFS) promotion type and product type could affect consumers to buy impulsively through emotional consumer reaction of hedonic motivation and positive affect, using the S-O-R model. The data were analyzed based on 188 responses who had completed questionnaires. Data were collected using the purposive sampling method with a minimum sample size of 138 from GPower calculation. The research used ANOVA and Regression Analysis to assess the model and utilizes SPSS. The result clearly illustrates that the maximum threshold of free shipping type with the hedonic product would lead more to consumer hedonic motivation. At the same time, the minimum threshold of free shipping type will induce too when combined with utilitarian products. Furthermore, consumer feelings of hedonic motivation and positive affect play an essential role in determining consumers’ impulsive buying behavior. The research benefits stakeholders in using and maximizing the free shipping promotion program.
Strategic Marketing Approach of Indonesia Aluminium Mineral Industry: Upstream and Downstream Analysis
Authors: Abdinagoro Sri Bramantoro , Hamsal Mohammad
Published: May 2023

The research aimed to determine the causes of imports by analyzing the upstream and downstream sides of the existing aluminium industrial chain. The research applied a descriptive-exploratory approach by collecting secondary data from credible sources. Interviews and focus group discussions with appropriate experts were also conducted to obtain supporting data. Research shows that aluminium imports will continue both in the short and long term. It is due to the upstream supply, especially in aluminium smelters, which cannot keep up with the increasing demand. Even though the market opportunity, especially in the automotive, construction, and power cable segments, is enormous and continues to grow, if there is not enough supply, the deficit of aluminium metal will continue to occur. It takes encouragement from the Government's political will to provide ease of electricity sources, increase production capacity and technology, change the mindset from relying on traders solely towards the mindset of the industrialist.