bluuebunny/crossref_metadata_2025 huggingface dataset:
Hipocalcemia grave como manifestación atípica de enfermedad celíaca seronegativa en un paciente con lupus eritematoso sistémico: reporte de un caso
Authors: Mejía Cardona Andrés Felipe , Rivera Martínez Wilfredo Antonio , Suárez Correa Juliana , Escobar Stein Juliana
Published: December 2023

Objetivo: describir la presentación clínica y diagnóstico de un episodio de hipocalcemia grave en un paciente con lupus eritematoso sistémico (LES) en remisión, con diarrea crónica que condujo al diagnóstico de enfermedad celíaca (EC).
Presentación del caso: paciente de 22 años, con diagnóstico de LES a los 10 años, en remisión. Consultó por 2 meses de evolución de parestesias, espasmos musculares, mialgias y episodios de tetania en la semana previa, asociado a diarrea posprandial malabsortiva. Sus laboratorios mostraron hipocalcemia grave, déficit de vitamina D, hipomagnesemia grave e hipopotasemia leve. En el estudio para EC la serología reportó antitransglutaminasa tisular IgA, antigliadina IgA e IgG normales y niveles de IgA total bajos. La enteroscopia evidenció bulboduodenitis erosiva, con atrofia de las vellosidades y aumento de linfocitos intraepiteliales en la patología, que junto al estudio inmunohistoquímico permitieron concluir el diagnóstico de EC, tipo Marsh 3a. Se inició el manejo con una dieta libre de gluten, con una respuesta clínica positiva.
Conclusión: la EC debe sospecharse en pacientes con LES que inicien con diarrea, dolor abdominal, náuseas/vómitos, aftosis oral recurrente y anemia. En los casos de EC seronegativa, los cuales son poco comunes, se deben descartar otras causas de atrofia de las vellosidades principalmente infecciosas, tóxicas e inmunitarias. Existe una asociación entre EC y LES, por lo cual el diagnóstico debe ser precoz y oportuno con el mejor esquema de pruebas disponible para lograr realizar un tratamiento efectivo antes de que se presenten las complicaciones.
Credit Accessibility and Growth of Small and Medium Enterprises in Bujumbura, Burundi
Authors: Delphin Bariko , Awolusi Olawumi Dele
Published: December 2023

The purpose of this study was to investigate the effect of credit accessibility on the growth of small and medium enterprises in Bujumbura, Burundi. The study was guided by the following objectives: i) to determine the effect of creditworthiness to credit accessibility on the growth of SMEs in Bujumbura; ii) to establish the effect of business characteristics to credit accessibility on the growth of SMEs in Bujumbura, and iii) to examine the effect of information available to credit accessibility on the growth of SMEs in Bujumbura. The study employed a descriptive survey research design. The target population was 347 and the sample size determined using the Slovenes formula was 186, but 167 respondents participated successfully in the study. The research instrument was a questionnaire and data were analyzed using frequency and percentage tables, mean and standard deviations, and linear and multiple regression analyses. The study found that creditworthiness to access credit had a significant effect on the growth of SMEs (Adjusted R2=0.059, p=0.001). In addition, the study revealed that business characteristics to access credit had a significant effect on the growth of SMEs (Adjusted R2=0.242, p=0.000). Furthermore, the study revealed that information available to access credit had a significant effect on the growth of SMEs (Adjusted R2=0.116, p=0.000). The study concluded that credit accessibility significantly affects the growth of SMEs. Thus, the study recommended that the owners of SMEs should strive to ensure that they have collateral security and proper documentation before they seek credit from financial institutions, SMEs should also form and register an association that is recognizable by law in Burundi. Likewise, the owners of SMEs should seek the support of professional auditors to audit their books of accounts at least every year.
O conceito de política pública e política educacional
Authors: Ó Celso Francisco do , Santos Caio Vinicius dos , Lorenzi Carla Cristina Biazi
Published: December 2023

Este artigo propõe realizar uma breve reflexão sobre a noção da implementação de políticas públicas, traçando um paralelo entre os meios pelos quais elas são estabelecidas como instrumento de organização da estrutura pública e seus desdobramentos que acabam influenciando a sociedade e sua organização. Foram utilizados Frey (2000), Sarmento (2012), Lascoumes e Galès (2012) e Mainardes, Ferreira e Tello (2011) para fundamentar a discussão. Trata-se, portanto, de um estudo bibliográfico de caráter qualitativo. Assim, o presente estudo buscou evidenciar que a política pública e a política educacional são instrumentos do Estado que devem contribuir para a sociedade, qualificando as práticas de órgãos públicos e tornando-os mais acessíveis.
Removal of lead and cadmium from aqueous solution using octacalcium phosphate as an adsorbent
Authors: Mirkovc Miljana , Bracanovic Ivan , Krstic Aleksandar , Djukic Dunja , Dodevski Vladimir , Kalijadis Ana
Published: December 2023

Octacalcium phosphate (OCP) is a material from the calcium phosphate group with a crystal structure similar to hydroxyapatite. The removal process of lead and cadmium in aqueous solution using octacalcium phosphate material was investigated. OCP material was synthesized by the solution precipitation method. The structural and phase properties of OCP before and after the removal process were determined by the X-ray diffraction (XRD) method. Microstructural and semi-quantitative analysis of the material was investigated by scanning electron microscopy and energy dispersive X-ray spectroscopy (SEM-EDS). Characteristic bands and functional group determination were revealed using the Fourier-transform infrared spectroscopy with attenuated total reflection (FTIR-ATR). As target pollutants, Cd(II) and Pb(II) were chosen in adsorption experiments. Results show that OCP in the first 10 min has a very fast removal rate for Pb(II); the equilibrium state was reached after 10 min with more than 98 % adsorption efficiency. Results for Cd(II), results showed the same removal rate but somewhat lower adsorption efficiency, amounted to approximately 63 %.
Physicochemical properties of bioplastic based on hydroxyethylcellulose and polyvinylpyrrolidone blend
Authors: Anwar Budiman , Nurhashiva Citra , Arwa Raihanah , Yuliani Galuh
Published: December 2023

The aim of this study is to develop a bioplastic based on hydroxyethylcellulose (HEC) and polyvinilpyrrolidone (PVP) which is applied as packaging materials. The effect of incorporation of PVP into HEC on the physicochemical properties of its blend films are investigated. The FTIR and DSC analysis denote that incorporation of PVP induce the intermolecular hydrogen bonds to occur more intensely. The XRD diffractograms indicate that the incorporation of PVP reduces the crystallinity of the film. The mechanical properties of the films become greater as the PVP content increases, and the optimum composition of HEC/PVP is at 5:3 mass ratio with a tensile strength of 34.8?3.4 MPa; elongation at break 104.3?4.9 %; and an elastic modulus of 0.10?0.02 GPa. The SEM and DSC analysis signify an excellent compatibility and miscibility between HEC and PVP. The incorporation of PVP increase the transparency and hydrophilicity of the film. The water vapor transmission rate of the films is relatively unchanged due to the incorporation of PVP. The TGA and DSC analysis reveal that the incorporation of PVP increases the thermal stability and the glass transition temperature of the film. This bioplastic film could be an alternative for biodegradable packaging material.
The effect of in-bed leg cycling exercises on muscle strength in patients with intensive care unit-acquired weakness: a single-center retrospective study
Authors: Shinohara Ayato , Kagaya Hitoshi , Komura Hidefumi , Ozaki Yusuke , Teranishi Toshio , Nakamura Tomoyuki , Nishida Osamu , Otaka Yohei
Published: December 2023

Objective: To examine the effect of in-bed leg cycling exercise on patients with intensive care unit-acquired weakness (ICU-AW).
Design: Single-center retrospective study.
Subjects/Patients: Patients admitted to the ICU between January 2019 and March 2023 were enrolled in the ergometer group, and those admitted to the ICU between August 2017 and December 2018 were enrolled in the control group.
Methods: The ergometer group performed in-bed leg cycling exercises 5 times per week for 20 min from the day of ICU-AW diagnosis. Furthermore, the ergometer group received 1 early mobilization session per day according to the early mobilization protocol, whereas the control group received 1 or 2 sessions per day. The number of patients with recovery from ICU-AW at ICU discharge and improvement in physical functions were compared.
Results: Significantly more patients in the ergometer group recovered from ICU-AW than in the control group (87.0% vs 60.6%, p = 0.039). Regarding physical function, the ergometer group showed significantly higher improvement efficiency in Medical Research Council sum score (1.0 [0.7–2.1] vs 0.1 [0.0–0.2], p < 0.001).
Conclusion: In-bed leg cycling exercise, in addition to the early mobilization protocol, reduced the number of patients with ICU-AW at ICU discharge.
Análisis estructural de un pórtico aplicando el método de rigidez
Authors:   Universidad Nacional Intercultural de la Selva Central Juan Santos Atahualpa, Chanchamayo, Perú., Rupay Vargas Marcos Josué , Baltazar Ariza Yesenia Ayeli ,   Universidad Nacional Intercultural de la Selva Central Juan Santos Atahualpa, Chanchamayo, Perú., Malpartida Quispe Abel Luis ,   Universidad Nacional Intercultural de la Selva Central Juan Santos Atahualpa, Chanchamayo, Perú.
Published: December 2023

Con esta investigación se ha desarrollado el análisis y la resolución a través del método de la rigidez sistematizado de una estructura con sección constante. Para su ejecución hemos empleado el método de la rigidez sistematizado y los procedimientos propios vistos en el curso de Análisis Estructural II en la UNISCJSA, siendo propios del sistema lo siguiente: Determinación del Sistema Q-D [Q], Determinación del sistema q-d (Local) Determinación de los coeficientes de Rigidez [K], Ensamblaje de la Matriz de Rigidez, Vector de Deformación [D] y fuerza de cada q-d, Respecto a la estructura desarrollada, tiene como características lo siguiente; es un pórtico con sección variable ABCDE. En la barra AB presenta una carga distribuida de 3 ton/m, Se considera el EA = ∞ en toda la estructura. Entonces se ha empleado un Sistema Q – D con cuatro grados de libertad posteriormente se ha calculado los valores correspondientes para cada elemento con la ayuda de la tabla de coeficientes de rigidez con sección constante y/o variable, asimismo se realizó el sistema complementario que consta en liberar a cada grado de libertad local para finalmente determinar la matriz de rigidez global y seguir con el proceso de encontrar la deformación y por último el valor de cada grado de libertad.
Assessment of Tetracyclines Residues Contamination in Chicken Meat Samples of Algiers Slaughterhouses Level
Authors: Radia Zamoum
Published: December 2023

Food contamination with antimicrobial residues may occur, entailing assessment and monitoring of the contamination level in edible tissue. In that way, 151 chicken meat samples were randomly collected from Algiers slaughterhouses. Otherwise, two analytical methods are validated for the simultaneous determination of oxytetracycline, tetracycline, doxycycline and chlortetracycline residues in edible chicken tissues, by liquid chromatography combined with mass spectrometry detection. Beforehand, an extraction step is performed. Indeed, acetonitrile is used as an extraction solvent for the qualitative method, and then the quantitative method is carried out after a preliminary extraction with an acidified EDTA-McIlvaine buffer, followed by a solid-phase extraction cleanup. Validation qualitative method results were satisfactory in terms of specificity (100%), sensivity, detection capability (CCß) and detection limit (LOD). Furthermore, validation results of the quantitative method was pertinent to the EU commission criteria. Thus, determination coefficient (r2) values were between de 0.91 to 0.98%, where the lowest values were observed for doxycycline. Trueness was between 85.5% and 104.8, expect for tetracycline (76.6% at 150µg/kg) and doxycycline (134.7% at 100µg/kg). As for intraday and interday precision, values respectively ranged between 12.5 and 26% and between 14 and 35%, except doxycycline for which precision values were higher. The methods have been successfully used for the identification, confirmation and quantification of tetracyclines in chicken muscle samples. Consequently, 25 samples were suspects in regard tetracyclines residues. The comparison of these samples with the QC at MRL (100µg/kg) revealed five samples needed a quantification. Thus, oxytetracycline, its epimer and doxycycline identified in samples were quantified. Indeed, all samples contained oxytetracycline and its epimer, doxycycline or both showed levels less than the decision limit (CCα).
A Connectivity between LRP-1 and Alzheimer’s Disease: Modulating the Transport and Clearance of Tau and Aβ Clearance from the Brain to the Liver
Authors: Duffy Lawrence K
Published: December 2023

A paucity of knowledge exists in our understanding of the axonal clearance of both beta amyloid (Aβ) and Tau proteins to the liver. Peripheral clearance by the liver can remove 40–50% of Aβ burden in the brain through the glial-lymphatic (glymphatic) system, transport across the blood brain barrier and mediated by low-density lipoprotein receptor-related peptide 1 (LRP-1). The lack of LDL receptors (LDLR) enhances amyloid deposition in the brain while LDLR overexpression increases the rate of Aβ entering the hepatic system. It’s important to consider the effects of organ failure on the development of AD. There are four main factors which contribute to clearance from the body. Blood flow, transport across the blood brain barrier, uptake into the liver, and elimination from the body through bile excretion all play an important role in the clearance of bioaccumulated toxic Aβ and Tau AD inducing proteins.
Exposure of Zebrafish (Danio rerio) to Clioquinol Reveals Embryological and Developmental Toxicity
Authors: Franco Jeferson Luis
Published: December 2023

Clioquinol (CQ) belongs to the 8-hydroxyquinoline family of antimicrobial agents. In the 1970s, CQ was withdrawn from the market due to reported neurotoxicity in humans. Although oral use was discontinued, topical formulations for treating fungal and parasitic infections remained available. With the potential reintroduction of oral CQ formulations for novel indications, a comprehensive understanding of its toxicity is essential. Thus, this study aimed to investigate the embryonic developmental toxicity of CQ in zebrafish. Embryos were exposed to concentrations of 0.1, 0.5, 1.0, 1.5, and 2.0 μg/ml of CQ for 168 hours, during which physiological, morphological, and behavioral parameters were assessed. Results indicate that CQ exhibited toxicity, causing 100% mortality within the first 48 hours at concentrations of 1.5 and 2.0 μg/ml. Additionally, a delay in hatching rate was observed after 72 hours of exposure to 1 μg/ml, and morphological abnormalities were evident at lower concentrations. Furthermore, exploratory behavior was evaluated in 7-day-old post-fertilization larvae exposed to the lowest CQ concentration, where severe morphological alterations were not observed. Exposure to CQ at 0.1 µg/ml led to altered swimming patterns, suggesting possible locomotor damage induced by CQ exposure. In conclusion, this study is the first to demonstrate the potential embryotoxicity of CQ in zebrafish, highlighting the importance of understanding the toxicity profile before considering its reintroduction for oral use.
The Role of VGLL4 in Development and Progression of Tumors
Authors: Yu Wei
Published: December 2023

The Hippo pathway plays an important role in controlling the size of organs, as well as cell proliferation, apoptosis and tumor formation. VGLL is a recently discovered family of proteins that can interact with TEAD, a transcription factor downstream of the Hippo pathway, and is an important regulatory factor in tumorigenesis. Unlike other members of the VGLL family, VGLL4 contains two TDU domains that can compete with YAP to bind TEADs to inhibit the transcriptional function of YAP. Overexpression of VGLL4 can inhibit malignant transformation of cells and is considered a tumor suppressor. VGLL4, as a transcriptional cofactor of the Hippo pathway, is involved in regulating the occurrence and development of tumors. Further studying the role and mechanism of VGLL4 in Hippo and other tumor-related pathways in the development and progression of cancer will provide new ideas for the prevention and treatment of human tumors.
Effect of Indian Herbal Formulation on Hepatomegaly: An Evidence Based Case Report
Authors: S Pandit
Published: December 2023

Enlargement of the liver, or hepatomegaly, occurs due to fatty liver disease, liver abscess, hepatitis, liver fibrosis, and carcinoma. Clinical diagnosis and PET CT scan revealed hepatomegaly with abscess in a 60-year-old male patient with a history of left laparoscopic radial nephrectomy due to cancer. The patient’s blood contained somewhat elevated levels of hepatic enzymes, including gamma glutamyl transferase (γ-GT), alkaline phosphatase (AKP) and alanine transaminase (ALT), which were indicative of damage to the liver cells. Diabetes, high blood pressure, obesity, and viral hepatitis were not reported. For a period of 12 weeks, the patient consumed oral Body Revival® liquid (BR) at a dose of 5 ml on alternate days. Physical, clinical, and laboratory examinations were conducted every four weeks. The patient’s liver enzymes were found to be within normal range following a 12-week course of BR treatment, and a CT scan examination showed that the patient’s liver had neither a confluent nor an abscess. At that time, there were no signs of liver abscess, hepatomegaly, or NAFLD.The patient had a full recovery after receiving Body Revival®.
EVALUASI PENGEMBANGAN PROFESIONALISME GURU MATA PELAJARAN EKONOMI DI SMA NEGERI KECAMATAN MUARA KUANG
Authors: Fahrianuddin Fahrianuddin , Fitria Happy , Mulyadi Mulyadi
Published: December 2023

This study aimed at evaluating and describing the Professionalism Development of Economics Subject Teachers at SMA Negeri Muara Kuang District. This research is a descriptive qualitative research. This research was conducted at SMA Negeri 1 Muara Kuang and SMA Negeri 2 Muara Kuang. The research subjects were the head of SMAN 1 Muara Kuang, the head of SMAN 2 Muara Kuang, the deputy head of SMAN 1 Muara Kuang, the deputy head of SMAN 2 Muara Kuang. 2 teachers at SMAN 1 Muara Kuang, 1 teacher at SMAN 2 Muara Kuang and 2 Supervisors for Development. Data collection techniques with observation, documentation and interviews. The data analysis technique was carried out in three stages: (1) data reduction, (2) data presentation, (3) conclusion drawing. The results showed that the development of the professionalism of the Economics Subject teacher at SMA Negeri Muara Kuang District had paid attention to all aspects of the context component, implemented several aspects of the input and process components. However, the output components have not been implemented properly.
PEMBELAJARAN BERDIFERENSIASI SEBAGAI MODUL AJAR PROJEK PENGUATAN PROFIL PELAJAR PANCASILA PADA SMK
Authors: Musa Anton , Dzakiyyuddin Mohammad , Ali Nurzen Amin Aang
Published: December 2023

This research was conducted due to the policy of renewing the national curriculum to the Merdeka Belajar curriculum, which contains Differentiated Learning approach and the Project for Strengthening the Pancasila Student Profile (P5) for elementary to high school levels. The interesting thing to study here is how to implement this policy in the realm of vocational education at SMK (Vocational High School). This research aims to investigate how the differentiated learning approach is implemented on the Project for Strengthening the Pancasila Student Profile in vocational schools. This research uses a qualitative approach with descriptive analysis methods. Data collection uses observation, interviews, and documentation studies. Miles and Huberman's interactive analysis techniques are used in data analysis, including data reduction, display, and conclusion drawing. This research shows that planning involves analyzing school readiness, forming committees, establishing success indicators, providing P5 training for teachers, mapping students using diagnostic assessments, determining P5 themes, and designing learning modules. Implementation includes P5 socialization, differentiated learning processes, product guidance, and productive expo projects. Evaluation has been carried out through reflection sessions at the end of each lesson, performance rubrics, and written tests. In general, a differentiated learning approach as module for the Project for Strengthening the Profile of Pancasila Students in Vocational Schools has been implemented continuously and has had a positive impact on students, as shown by increased enthusiasm and satisfactory assessment results.
KEBIJAKAN CYBER ISLAMIC UNIVERSITY DALAM PENINGKATAN SDM DI ERA SOCIETY 5.0
Authors: Fadli Faisal , Miftah Muhammad
Published: December 2023

The Indonesian government, through the Ministry of Religion, has established the Islamic University cyber policy as one of the Ministry of Religion's 7 policy priorities. The cyber-Islamic university policy is motivated by the issue of equal distribution of education (especially Islamic education) in Indonesia which is still minimal. The Ministry of Religion records that there are tens of thousands of teacher educators who have not studied at university level. This then became one of the reasons for formulating a cyber-Islamic university policy with IAIN Nurjati as the first pilot project. In its implementation, CIU policy not only has a role in equalizing education in Indonesia, but also has a role in improving human resources in Indonesia. Human resources or HR is something that needs to be improved, in relation to the progress of the times until we reach the 5.0 era. In this research, the researcher aims to analyze the Islamic University cyber policy as one of the ways the government has taken to improve human resources and the role of this policy in preparing Indonesian society to adapt to the Society 5.0 era. The research method used by researchers is library research, using the Ministry of Religion Decree regarding the appointment of IAIN Nurjadi as a pilot project for implementing CIU policies as the main data source. Researchers use a theory related to society 5.0 which was initiated by Fukuda, the idea is that society 5.0 has a humanist side where humans are made the center so that society can experience a quality social atmosphere. The results of this research are that researchers found that human resources are an important thing to improve in the era of society 5.0, and one way to improve human resources in Indonesia is the implementation of the cyber-Islamic university policy
Heart Dominated by Solitary Coronary: A Case Report
Authors: Jafri Anwar Nabeel , Alqarni Mohammed Hassan Muaidh , Al Shehri Mohammad
Published: December 2023

The prevalence of coronary artery anomalies has been detected in 0.6% to 1.5% of coronary angiography. They are found since birth but usually with no significant symptoms and it does not generally manifest as myocardial ischemia however, malignant outcomes have been reported. Single coronary arteries are rare congenital anomalies in which the entire circulation for the heart is supplied by a coronary artery originating from a single ostium. It is challenging to recognize the anomaly of the patient’s coronaries, experiencing percutaneous coronary intervention (PCI) procedure, undergoing coronary artery surgery, or receiving a prosthetic valve replacement. In our case, we document a patient who underwent PCI for multi-vessel coronary lesions and in whom the atypical origin of the single left coronary artery, with the right coronary artery (RCA) emerging from the distal left circumflex artery (LCX), which was previously undetected.
FINANCIAL SHENANIGANS AND COMPANY CHARACTERISTICS IN INDONESIA PUBLIC COMPANY
Authors: Murni Siti Asiah , Tumewu James
Published: December 2023

Financial shenanigans are moves made by a company's management with the intention of falsifying the company's financial status and stated performance. The goal of this study is to clarify if financial considerations and company size have an impact on a company's propensity to engage in financial misdeeds in Indonesian public companies. Financial leverage, financial stability, personal financial need, and return on assets are the financial characteristics that were examined in this study. An Indonesian firm that has gone public serves as the study's sample. Purposive sampling was used in this study's sampling. This study's analysis method makes use of multiple linear regression. The findings revealed that the company was unaffected by all variables except for financial leverage.
ENTREPRENEURSHIP ORIENTATION, MARKET ORIENTATION AND INNOVATION TOWARD COMPETITIVE ADVANTAGE
Authors: Yani Ahmad , Jauhari Ahmad
Published: December 2023

This research was conducted to find out about the marketing strategies of the emping mlinjo business actors which are less effective from the aspect of entrepreneurial orientation, market orientation and the absence of product innovation. The location of this research is the Small & Medium Industry Center (IKM) Krupuk Emping Mlinjo Mojo Kediri. Respondents in this study were business actors as many as 31 people who were used as samples. The analysis technique was carried out by descriptive analysis and inferential statistics through validity, reliability, classical assumption tests, multiple linear regression tests, t tests and F tests. The entrepreneurial orientation variable partially and significantly affects the competitive advantage of emping mlinjo SMEs in Mojo Kediri with a t count of 3,844 > t table of 2,039 with a significant value of 0.001 < 0.05. The market orientation variable partially has no effect on the competitive advantage of the emping mlinjo SMEs in Mojo Kediri with a t count of 1.181 < t table of 2,039 with a significant value of 0.248 > 0.05. The innovation variable partially and significantly influences the competitive advantage of the emping mlinjo SMEs in Mojo Kediri with t count of 2,485 > t table of 2,039 with a significant value of 0.019 < 0.05. Simultaneously entrepreneurial orientation, market orientation and innovation have a significant effect on the competitive advantage of business actors in the emping mlinjo Mojo Kediri IKM. This result is evidenced by the calculated F value in this study of 18.769 and the significance value of F is 0.000 is <0.05. It is hoped that business actors will continue to focus their efforts on factors that can help in navigating the competition with innovation and looking at market share so that they have a competitive advantage.
GENERACIÓN DE DATOS SINTETICOS PARA EVALUAR LA ENFERMEDAD INFECCIOSA LEUCOSIS BOVINA
Authors: Ballesteros-Ricaurte Javier Antoni , González-Sanabria Juan Sebastián , Ordóñez Hugo
Published: December 2023

Los proyectos que se desarrollan en el sector de salud animal se enfrentan a limitaciones tecnológicas y científicas debido a la falta de información consistente y confiable, y a los altos costos que supone la recolección de información para los ganaderos. Así mismo, las limitaciones jurídicas en la divulgación de información por razones como las leyes de protección de datos conllevan atrasos en el desarrollo de políticas y estrategias, lo mismo que en la toma de decisiones. Ante esta falta de disponibilidad de información surge como solución la generación de datos sintéticos a partir de un conjunto de datos originales. Así, en este artículo se presenta un estudio a través del cual se valoraron tres métodos para generar datos sintéticos que reflejan el comportamiento de una enfermedad bovina en un conjunto de datos reales. El trabajo se basó en comparar algoritmos de aprendizaje automático, herramientas y métodos basados en modelos para mejorar el realismo de los datos sintéticos referidos al comportamiento de la enfermedad. El objetivo trazado fue encontrar el mejor modelo para la generación de datos sintéticos utilizando el caso de la enfermedad infecciosa mastitis bovina, ya que no se cuenta con suficientes datos sobre ella. Para validar los datos sintéticos fue necesario contrastar el conjunto de datos original y la información sintética, en busca de que el método seleccionado generara datos sintéticos con cualidades similares a las del conjunto de datos original.
Features of teaching hygiene in the medical university considering specialization and digitalization
Authors: Fertikova TE , Chernykh NYu , Melikhova EP , Skrebneva AV , Libina II , Khatuaev RO , Vasilieva MV
Published: December 2023

The issue of organizing the teaching of hygiene considering specialization of the medical university faculties is relevant in the context of digitalization. Proficiency in digital skill determines the modern professional physician’s competitiveness. The paper provides analysis of the use of digital technologies to study the relevant issues of hygiene. Educational process at the Department of General Hygiene of the Voronezh State Medical University is built on the principle of uniformity and consistency. Professional educational trajectory, including that on digital platforms, considers the teaching continuity, from fundamental theoretical subjects to clinical and specialized ones. Within the framework of educational process, issues of special hygiene, such as specifics of structure and use of medical institutions, features of professional activity of physicians of various specialties, are considered. Conventional methods to teach hygiene are supplemented with the differentially used innovative teaching techniques. The business game method is successfully used by the future clinicians to master the topic “Food Poisoning”. The method of creating educational videos for visual demonstration of laboratory work can be used in distant learning. The digital learning method demonstrates the possibility of using advanced digital devices and internet-based technologies in preventive medicine. It seems necessary to further improve the educational process at all the faculties as educational and professional standards, as well as the academic passport for Hygiene, are updated.
INOVASI PENILAIAN KUALITAS AIR SUNGAI BERBASIS KONDISI MAKROINVERTEBRATA MENGGUNAKAN FORMULA DYTERAasDAS
Authors: Yudistira Risky , Prawati Eri , Rolia Eva
Published: December 2023

Dengan menggabungkan data lapangan tentang makroinvertebrata dan kondisi lingkungan, formula ini memberikan gambaran yang lebih komprehensif tentang kualitas air sungai. Penilaian kualitas air sungai berdasarkan makroinvertebrata memiliki potensi untuk menjadi alat yang lebih sensitif dan informatif dalam memantau kesehatan ekosistem sungai. Selain itu, formula DYTERasDAS juga dapat memberikan panduan yang lebih tepat dalam merancang dan mengimplementasikan tindakan konservasi dan perbaikan kualitas air sungai. Penelitian ini diharapkan dapat memberikan kontribusi yang signifikan dalam upaya pelestarian dan pengelolaan sungai-sungai yang sangat berharga bagi kehidupan manusia dan ekosistem. Sub daerah aliran sungai (DAS) Metro merupakan salah satu aliran sungai yang membentang di Kabupaten Pada daerah metro terdapat luas daerah kasus kali ini bertepatan di kecamatan metro yang berada di Metro Pusat dengan luas wilayah 11,71 km²/sq. ,Kecamatan Metro Utara dengan luas wilayah 22,14 km²/sq, dan Kecamatan Metro Selatan dengan luas wilayah 15,01 km²/sq.Dalam penelitian ini menggunakan metode kuantitatif dengan cara identifikasi lokasi untuk mengetahui kesehatan DAS dan pengambilan sampel indicator makhluk makroinverteberata berdasarkan pengaruh lingkungan di DAS Metro yang bertepatan di Kecamatan Metro Pusat, Metro Selatan, Metro Utara. Dimana penelitian dilakukan dengan metode survei dan analisa. Dapat disimpulkan bahwa di Kecamatan Metro Pusat dan Metro Selatan terdapat beberapa lokasi yang telah diperiksa dengan skor indikator biotik makroinvertebrata yang sangat tinggi, yang kemungkinan merupakan salah satu sungai dengan tingkat pencemaran yang cukup signifikan, dibandinkan dengan Kecamatan Metro Utara yang telah di periksa skor indikator biotilik makroinvertebrata yang masih terjaga ekosistem nya dengan pencemaran sangat ringan. Dalam perhitungan DYTERasDAS menggunakan indikator makroinverteberata tersebut menggunakan kualitas renjim aliran air (KRA) terdapat kualifikasi pemulihan yang sangat rendah dengan nilai 0,096 dan koefisien aliran tahunan dengan beberapa Sub DAS di Kecamatan Metro masih bisa di katakana sangat tinggi dengan nilai 911,0 di bulan bulan Mei. Perhitungan menggunakan formula DYTERasDAS ternyata dapat di jelaskan bahwa sungai sungai yang di Kecamatan Metro Pusat ternyata masih terbilang rendah Sub penilaian asesmen kondisi bentaran sungai yaitu 2,16 sedangkan di Kecamatan Metro Selatan dan Metro Utara terbilang tinggi.
Global prevalence of enterobiasis in young children over the past 20 years: a systematic review and meta-analysis
Authors: Lashaki Elham Kia , Mizani Azadeh , Hosseini Seyed Abdollah , Habibi Bentolhoda , Taherkhani Khadijeh , Javadi Amir , Taremiha AliReza , Dodangeh Samira
Published: December 2023

Parasitic infections are the most common diseases worldwide, and enterobiasis is a common parasitic infection in children. Various studies have reported on the prevalence of Enterobius vermicularis in different regions of the world. However, no study has gathered and analyzed this data systematically. Our systematic review and meta-analysis investigated the overall prevalence of E. vermicularis among children globally. Data were extracted from 4 available databases for studies published from January 2002 to April 2022. The quality of the included studies was scored based on the standard Strengthening the Reporting of Observational Studies in Epidemiology. A random-effect model was chosen to calculate the pooled prevalence and corresponding 95% confidence interval (CI) according to the degree of heterogeneity in the included studies. Thus, 40 publications (42 data sets) that included 3,279 children with enterobiasis met all criteria and were included in the analysis. The meta-analysis showed that heterogeneity among the included studies was high (Q=4,399.35, I2=99.96%; df=41; p<0.001). The pooled global prevalence of enterobiasis among the studied children was 12.9% (95% CI, 8.2%–17.7%). Our systematic review and meta-analysis estimated that, for the past 20 years, 12.9% of children around the world have been infected with E. vermicularis.
Analysis of Total Phenol and Flavonoid Compounds in Temulawak (Curcuma xanthorrhiza Roxb.) Tablets Based on Differences in Maltodextine Concentration
Authors: Indriani Dina Wahyu , Mutiarani Nadya , Lastriyanto Anang
Published: December 2023

Temulawak (Curcuma xanthorrhiza Roxb.)  has empirical phenolics and flavonoids which can act as antioxidants. The purpose of this study was to produce tablets of temulawak (Curcuma xanthorrhiza Roxb.) with variations in the addition of maltodextrin concentration and to find the best results. This research was conducted using a non-factorial Randomised Block Design (RBD) with 3 treatment levels, the ratio of maltodextrin to 1:2 (50%), 1:4 (25%) and 1:6 (16.70%).  The results of this study showed that all tablets formed met the requirements of BPOM Number 32 of 2019 such that the tablets must be less than or equal to 10% and all the shaped tablets had a uniform weight. The tablets with 1:2 (50%) treatment had the highest value which was able to produce the highest total mean value of phenolics and flavonoids when compared with 1:4 (25%), 1:6 (16,70%) and control treatments. In a 1:2 (50%) treatment, the total phenolic value was 3.63 mg GAE/g ± 0.09, while the total flavonoid value was 6.11 mg QE/g ± 0.30. Therefore, it can be stated that the maltodextrin concentration treatment with a ratio of 1:2 (50%) was the optimum method for producing temulawak (Curcuma xanthorrhiza Roxb.) tablets in this study.
Competitiveness of higher education systems: Exploring the role of migration flow
Authors: Kwilinski Aleksy , Lyulyov Oleksii , Pimonenko Tetyana , Pudryk Denys
Published: December 2023

Intellectual capital is one of the most crucial determinants of long-term economic development. The countries compete for highly skilled labor and talented youth. State regulatory interventions aim to, on the one hand, facilitate the retention of foreign high-productivity intellectual capital in the host country, transforming ‘educational’ and ‘scientific’ migrants into residents, and on the other hand, prevent the outflow of their own qualified workforce. The paper aims to outline the role of the nation’s higher education system in the influx and outflow of labor resources. A two-stage approach is applied: 1) maximum likelihood—to cluster the EU countries and the potential candidates to become members of EU countries based on the integrated competitiveness of their higher education systems, considering quantitative, qualitative, and internationalization aspects; 2) logit and probit models—to estimate the likelihood of net migration flow surpassing baseline cluster levels and the probability of migration intensity changes for each cluster. Empirical findings allow the identification of four country clusters. Forecasts indicate the highest likelihood of increased net migration flow in the second cluster (66.7%) and a significant likelihood in the third cluster (23.4%). However, the likelihood of such an increase is statistically insignificant for countries in the first and fourth clusters. The conclusions emphasize the need for regulatory interventions that enhance higher education quality, ensure equal access for migrants, foster population literacy, and facilitate lifelong learning. Such measures are imperative to safeguard the nation’s intellectual potential and deter labor emigration.
Green knowledge management to achieve corporate sustainable development
Authors: Widyanti Rahmi , Rajiani Ismi , Basuki Basuki
Published: December 2023

The mining industry significantly impacts the three pillars of sustainable development: the economy, the environment, and society. Therefore, it is essential to incorporate sustainability principles into operational practices. Organizations can accomplish this through knowledge management activities and diverse knowledge resources. A study of 300 employees from two of the largest mining corporations in South Kalimantan, Indonesia, found that four out of five elements of knowledge management—green knowledge acquisition, green knowledge storage, green knowledge application, and green knowledge creation—have a direct impact on the sustainability of businesses. The calculation was determined using Structural Equation Modelling (SEM). However, the study also found that the influence of collectivist cultural norms inhibits the direct effect of green knowledge sharing on corporate sustainable development. The finding suggests that companies operating in collectivist cultures may need to take additional measures to encourage knowledge sharing, such as rewarding employees for sharing their expertise on green initiatives, supportive organizational culture, clear expectations, and opportunities for social interaction.
A Novel Approach for Solving Nonlinear Time Fractional Fisher Partial Differential Equations
Authors: Shwayyea Rana T.
Published: December 2023

This study focuses on solving non-linear time fractional Fisher partial differential equations using analytical series solutions. The authors consider the Caputo fractional derivative in their formulas, which adds accuracy to the results. They introduce a novel method called LRPS which proves to be a powerful tool for obtaining precise analytical and numerical solutions for these equations. The LRPS method emphasizes precision, effectiveness, and practical application, making it suitable for various fields such as physics, engineering, and finance. Due to the importance of accuracy, effectiveness and method of application in this approach, it is highlighted that accurate solutions can be obtained when there is a pattern in the parts of the series, while approximate estimates are provided otherwise. The LRPS method is presented as a powerful technique specifically designed for solving nonlinear fractional Fisher partial differential equations.
Strongly J-n-Coherent rings
Authors: Zhu Zhanmin
Published: December 2023

Let $R$ be a ring and $n$ a fixed positive integer. A right $R$-module $M$ is called strongly $J$-$n$-injective if every $R$-homomorphism from an $n$-generated small submodule of a free right $R$-module $F$ to $M$ extends to a homomorphism of $F$ to $M$; a right $R$-module $V$ is said to be
strongly $J$-$n$-flat, if for every $n$-generated small submodule $T$ of a free left $R$-module $F$, the canonical map $V\otimes T\rightarrow V\otimes F$ is monic; a ring $R$ is called left strongly $J$-$n$-coherent if every $n$-generated small submodule of a free left $R$-module is finitely presented; a ring $R$ is said to be left $J$-$n$-semihereditary if every $n$-generated small left ideal of $R$ is projective. We study strongly $J$-$n$-injective modules, strongly $J$-$n$-flat modules and left strongly $J$-$n$-coherent rings. Using the concepts of strongly $J$-$n$-injectivity and strongly $J$-$n$-flatness of modules, we also present some characterizations of strongly $J$-$n$-coherent rings and $J$-$n$-semihereditary rings.
Enhanced intestinal permeability to 51Cr-labeled EDTA in dogs with small intestinal disease
Authors: Hall Edward J. , Batt Roger M.
Published: December 2023

Intestinal permeability in dogs with small intestinal disease was measured by quantitation of 24-hour urinary excretion of 51Cr-labeled EDTA following intragastric administration. Permeability was high in dogs with a variety of naturally acquired small intestinal diseases including wheat-sensitive enteropathy of Irish Setters, small intestinal bacterial overgrowth, and giardiasis, and permeability was decreased after successful treatment. These findings indicate that the assessment of intestinal permeability may be a useful technique for detecting small intestinal disease and for monitoring the efficacy of treatment in dogs.
Serologic and histologic diagnosis of toxoplasmic abortions in sheep in Oregon
Authors: Dubey J. P. , Sonn R. J. , Hedstrom O. , Snyder S. P. , Lassen E. D.
Published: December 2023

Between 1983 and 1989, we examined 586 fetuses and dead lambs submitted to a diagnostic laboratory in Oregon. Toxoplasmosis was diagnosed in 74 (12.6%), campylobacteriosis in 89 (15.2%), chlamydiosis in 75 (12.8%), miscellaneous infections in 153 (26.1%), noninfectious causes in 37 (6.3%), and undetermined causes in 158 (27.0%). Detection of Toxoplasma gondii agglutinating antibodies (≥ 20) in body fluids or heart serum was considered specific for the diagnosis of toxoplasmosis in ovine fetuses or lambs. Toxoplasma gondii antibody titers (reciprocal) in 285 fluids from fetuses or dead lambs were < 20 (64.5%), 20 (4.5%), 40 (1.7%), 80 (0.7%), 160 (2.1%), 320 (1.7%), 640 (4.9%), 1,280 (2.8%), 2.560 (4.5%), 5,120 (3.8%), 10,240 (2.1%), and ≥ 20,480 (6.3%).
Prevalence of Toxoplasma gondii antibodies in dairy goats from 1982 to 1984
Authors: Dubey J. P. , Adams D. S.
Published: December 2023

Serum samples from 1,000 dairy goats from northwest United States (1982 to 1984) were examined for Toxoplasma gondii antibodies by a modified agglutination test. Toxoplasma gondii antibody titers were <1:40 for 779 goats, 1:40 for 153 goats, and ≥1:400 for 68 goats. Seroprevalence increased with age of goats; 3.7% of 54 six-month-old goats were seropositive (≥1:40) vs 17.8% of 218 one-year-old goats.
Seroprevalence of Actinobacillus (Haemophilus) pleuropneumoniae serotype-1 infection in swine herds in Quebec
Authors: Vaillancourt Jean-Pierre , Martineau Guy-Pierre , Larivière Serge , Higgins Robert , Mittal Khyali R.
Published: December 2023

Seroprevalence of Actinobacillus (Haemophilus) pleuropneumoniae serotype-1 infection was evaluated in pigs on 7 farms in Quebec. Commercial cross-bred herds A to G, ranging from 110 to 235 sows and infected with A pleuropneumoniae serotype-1 were selected. Five pigs/litter were selected at random and were identified (group 1). Blood samples were obtained from group-1 pigs at 2 to 4, 14, 28, 42, and 56 days of age. Blood also was obtained from group-1 pigs remaining in the postweaning unit at 70 days of age, and from 20 to 40 sows 1 to 3 times.

To determine prevalence of seropositive pigs in all age groups for the entire study period in herds C to G, blood samples were obtained from 20 pigs/age group (group 2) selected at random at 28, 42, and 56 days of age at each visit. Group-1 pigs were included when they reached 28, 42, and 56 days of age. Pigs were serologically monitored in herds A and B for 3 months and in herds C to G for 5 to 6 months.

Serologic status of pigs at 2 to 4 days of age was not statistically associated with status at 42 days (P = 0.6293) and at 56 days (P = 0.3098) of age for the same pigs. Therefore, seronegative pigs 2 to 4 days old did not seroconvert earlier than did those with detectable maternal antibodies at 2 to 4 days old. Only about 50% of the 70-day-old pigs were seropositive at 56 days. Seemingly, pigs seroconverted late in the postweaning period.

Prevalence of seropositive 42- and 56-day-old pigs varied among and within herds over a short period. The prevalence of A pleuropneumoniae infection in the adult population was not related to the prevalence of the infection in weaned pigs.
Antibody production and tissue irritation in swine vaccinated with Actinobacillus bacterins containing various adjuvants
Authors: Straw B. E. , Shin S. , Callihan D. , Petersen M.
Published: December 2023

The effects that Actinobacillus pleuro-pneumoniae bacterins containing paraffin (mineral) oil, Al(OH)3, or lecithin-base oil adjuvants had on antibody production and muscle irritation were studied. Four hundred and thirty-two pigs were vaccinated twice (864 injection sites) at a 30-day interval. To assess effects of skin surface contamination on tissue reaction, 247 of the injections were made through skin soiled with manure. Serum samples for antibody determination and tissue samples were obtained at slaughter (15 to 90 days after vaccination). Bacterins containing Al(OH)3 or 5% lecithin-base oil as an adjuvant resulted in minimal tissue irritation. Bacterins containing paraffin oil or >20% lecithin-base oil were more irritating to muscle, often resulting in a granuloma or an abscess at the injection site. Pigs given bacterins containing Al(OH)3 adjuvant had lower antibody titers than did pigs given bacterins containing paraffin oil or lecithin-base oil adjuvants.
Protozoal encephalomyelitis in horses: 82 cases (1972-1986)
Authors: Boy Mary Gardiner , Galligan David T. , Divers Thomas J.
Published: December 2023

Medical records of 82 horses with clinical signs of neurologic disease and histologic lesions suggestive of protozoal encephalomyelitis were reviewed. The presence of a protozoan parasite in the cns was not influenced by prior treatment of the horse with corticosteroids. Prior treatment of horses with trimethoprim-sulfonamide alone or in combination with pyrimethamine resulted in a decreased number of horses in which a protozoan parasite was detected in the cns at necropsy. The mean age of affected horses was 3.62 ± 2.78 years, with male and Standardbred horses being overrepresented, compared with that of the hospital population of horses that were studied at the same time.