bluuebunny/crossref_metadata_2025 huggingface dataset:
Pelatihan Akuntansi Manajemen dengan Penerapan Transaction Processing System bagi UMKM yang Berproduksi Menurut Pesanan di Banda Aceh
Authors: Ahmad Lukman , Idwan Harry , Imilda Imilda , Tarmizi Tarmizi
Published: September 2023

Pencatatan transaksi adalah kegiatan rutin yang harus dilakukan dalam operasional bisnis. Merupakan kegiatan data-entry yang sangat diperlukan untuk proses bisnis selanjutnya. Transaction Processing System (TPS) adalah pendukung untuk system informasi lainnya, seperti sistem Informasi akuntansi yang sangat diperlukan oleh manajemen suatu bidang usaha. Termasuk UMKM membutuhkan TPS untuk operasinal bisinisnya. Di pasaran telah banyak tersedian aplikasi TPS bahkan berupa mesin kasir Cash Register. Namun bagi UMKM yang memproduksi barang berdasarkan pesanan khusus (special order) haruslah memiliki TPS khusus yang dapat disebut Order Register System. Kemudian hasilnya dapat ditidak-lanjuti ke proses akuntansi, dan untuk pengambilan keputusan. Semua kegiatan itu termasuk kedalam manajemen akuntansi. Di dunia bisnis, UMKM membutuhkan ketrampilan dan pengetahuan tersebut agar dapat bersaing dan berkembang. Jadi pelaksanaan kegiatan Pengabdian Kepada Masyarakat (PKM) yang dilakukan adalah memberikan pelatihan pengaplikasian TPS dan akuntansi manajemen. Sedangkan UMKM objek pelaksanaannya di Al Mathar Bingkai, kelurahan Peunayong, kecamtan Kuta Alam, kota Banda Aceh. Hasil kegiatan pengabdian kepada masyarakat menunjukan bahwa para peserta dapat mengaplikasikan bagaimana memudahkan keputusan bisnis, mempredisksi bisnis di masa mendatang, menganalisa tingkat pengembalian, untuk dapat mengidentifikasi masalah bisnis dan untuk perencanaan bisnis.
Pemberdayaan Ibu PKK Melalui Pemanfaatan Material Daur Ulang Botol Bekas Untuk Pembuatan Tanaman Hias Dengan Media Vertikal Garden Pada Masa New Normal Covid-19
Authors: Budiyono Debora , Kurniawan Hendra , Sumiati Astri , Putri Rona Sari Mahaji , Putri Sri Andika
Published: September 2023

Pada masa new normal Covid-19 memberikan banyak dampak seperti batasan kegiatan di luar dan kondisi ini berdampak pada masyarakat Indonesia sehingga kurang aktif dan kreatif serta secara kesehatan (psikologis) telah merasa bosan dengan rutinitas sama yang diam di rumah saja. Salah satu kelompok masyarakat yang mengalami mati suri yaitu kelompok ibu PKK Perumahan Landungsari, Kabupaten Malang. Potensi yang dapat dikembangkan yaitu keinginan kelompok ibu PKK Perumahan Landungsari, Kabupaten Malang untuk dapat beraktivitas dengan memanfaatkan sisa limbah keluarga yang cukup banyak di rumah masing-masing seperti seperti botol  bekas. Tujuan kegiatan pengabdian kepada masyarakat adalah membantu kelompok para ibu PKK Perumahan Landungsari memanfaatkan limbah botol bekas  untuk pembuatan tanaman hias vertikal garden pada masa new normal Covid-19. Metode yang digunakan dalam pengabdian kepada masayarakat yaitu pelatihan sedangkan untuk implementasikan solusi yang telah dilaksanakan yaitu persiapan, pelaksanaan, dan evaluasi. Berdasarkan hasil kegiatan pengabdian yang telah dilakukan bahwa ibu PKK Perumahan Landungsari sangat antusias belajar terkait pembuatan tanaman hias vertical garden dengan menggunakan botol bekas. Sedangkan tingkat keberhasilan pembuatan vertical garden yang telah dilakukan berhasil sebanyak 90% dengan indikator tanaman hias dapat hidup dengan baik. Selain itu warga perumahan Landungsari memiliki vertical garden yang fungsional dan estetika pada masing-masing rumah tempat tinggal.
Pencatatan Laporan Posyandu Di Wilayah Kerja Puskesmas Sukorame Kota Kediri
Authors: Nurwijayanti Nurwijayanti , Sofyan Wahyu Kumara Sofyan Wahyu , Wijaya Putri Retno , Sudibdyo Agung , Hidayat Poppy , JS Armando Hadyono , Dwi Jaya Adetya Wahyu , Amalya Gretta Hapsari
Published: September 2023

Sistem pelaporan hasil penimbangan balita yang masih manual membuat waktu pelaporan lebih lama. Dukungan teknologi dan kemampuan kader dimungkinkan mampu mempercepat sistem pelaporan kepada ahli gizi. Tujuan dari pengabdian masyarakat ini implementasi aplikasi sederhana dalam Pencatatan Laporan Posyandu di Wilayah Kerja Puskesmas Sukorame Kota Kediri. Metode yang digunakan dalam kegiatan ini adalah uji coba link untuk mencatat laporan hasil timbang balita secara online. Tim membuat link yang dibagikan kepada kader untuk melaporkan hasil timbang balita secara online. Tim membuat link evaluasi kegiatan pelaporan online. Hasil pengabdian masyarakat ini menghasilkan respon positif dari seluruh kader. Adapun kendala yang dihadapi adalah gangguan jaringan dan pemahaman terhadap teknologi antar kader yang berbeda.
Inovasi Tanaman Refugia Dan Pupuk Hijau Di Kebun Sayur Cantewa Kelurahan Mojolangu, Kota Malang
Authors: Wicaksono Karuniawan Puji , Permanasari Paramyta Nila , Saitama Akbar , Zahro Frelyta Ainus , Sandy Yohana Avelia , Tyasmoro Setyono Yudo , Sebayang Husni Thamrin , Widaryanto Eko
Published: September 2023

Pemakaian pestisida maupun pupuk kimia secara terus menerus pada tanaman akan memberi dampak negatif terhadap lingkungan, tanaman bahkan manusia. Dampak lainnya yaitu tingginya biaya yang dikeluarkan oleh petani dan dapat membunuh organisme yang berperan sebagai musuh alami bagi hama tanaman. Tujuan kegiatan ini yaitu meningkatkan pemahaman kelompok tani perkotaan untuk penerapan tanaman Refugia dan Pupuk Hijau pada budidaya tanaman pangan maupun hortikultura. Kegiatan ini dilakukan secara luring dan daring pada bulan September Tahun 2021. Kegiatan ini dimulai dengan menyebarkan kuisioner untuk pengambilan data primer, dilanjutkan dengan penyuluhan dan diskusi bersama, serta yang terakhir yaitu pembagian modul untuk bahan materi. Pengendalian OPT dengan cara pemanfaatan tanaman refugia akan dapat memberikan teknologi yang ramah lingkungan, ekonomis, dan dapat memperindah lahan tanaman budidaya pertanian khususnya pada kegiatan ini adalah tanaman sayuran di Kebun Sayur Cantewa Kelurahan Mojolangu, Kota Malang. Tanaman refugia sangat memiliki potensi yang tinggi untuk dikembangkan, cara peenggunaanya relatif murah, mudah dan sederhana. Pembuatan dan perbanyakan Tanaman Refugia diharapkan menjadi sebuah alternatif bahan pengendalian OPT pada tanaman pangan. Kemudian dapat segera dikembangkan rumah pupuk untuk pembuatan pupuk hijau di Kebun Sayur Cantewa untuk memperbaiki tanah serta dapat memberika nnutrisi bagi tanaman dengan mengurangi penggunaan pupuk anorganik atau kimia.
Tamasya Edukasi Daring (TARING) Sebagai Kegiatan Edukasi Di Luar Kelas Saat Pandemi Covid-19
Authors: Rizqi Miftakhul , Annisa Indah Chairun , Dwi Putra Andi Kurniawan , Noviana Premitha Evi , Etty Ettyani , Dhewy Risdiana Chandra
Published: September 2023

Di masa pandemi Covid-19 ini pembelajaran tetap harus dilakukan meskipun melalui daring. Oleh karena itu peserta didik perlu diberikan berbagai pilihan media untuk mendukung proses belajarnya, salah satunya yaitu melalui tayangan video jelajah virtual Tamsya Edukasi Daring. Program ini bertujuan untuk memberikan sensasi jalan-jalan langsung bagi peserta didik di tempat-tempat wisata yang belum pernah dikunjungi. Terutama tempat-tempat wisata yang berbiaya mahal. Sasaran dari program ini yaitu Bimbel dan TPQ Amanah di Kecematan Sukodono, Kabupaten Sidoarjo, yang mana sebagian besar peserta didik di tempat tersebut merupakan kalangan masyarakat menengah ke bawah. Metode pelaksanaan kegiatan ini adalah penentuan lokasi wisata, pengambilan gambar di tempat wisata yang dituju, penyatuan gambar menjadi bentuk video, pengisian suara, penyuntingan akhir video, penayangan hasil video ke peserta didik, dan pengisian angket respons oleh peserta didik. Hasil dari kegiatan ini yaitu berupa video dari berbagai tempat, dan buku pedoman pelaksanaan kegiatan pengabdian. Kemudian dengan adanya hasil video tamasya edukasi daring ini dapat menjadi salah satu media pembelajaran yang sudah disesuaikan dengan kurikulum.
Pendampingan Lansia Menuju Sehat Dengan Tanaman Obat Keluarga (TOGA)
Authors: Oktavianisya Nelyta , Aliftitah Sugesti , Inayati Hosnu
Published: September 2023

Usia lanjut adalah masa perkembangan yang  ditandai  dengan  menurunnya  sistem dalam tubuh yaitu  kondisi fisik,  mental dan sosial yang akan mempengaruhu kualitas hidupnya. Program yang dapat meningkatkam kesehatan lansia adalah memberikan aktifitas lansia agar selalu berbahagia, bersosialisasi dan berkarya atau produktif. Masalah yang ada di Desa Kebundadap Timur adalah kegiatan lansia di Desa Kebundadap Timur yang terlalu monoton sehingga mengganggu kesehatan lansia salah satunya dapat menimbulkan stress, dan dampaknya bisa menurunkan kualitas hidup lansia. Di Desa Kebundadap Timur sebanyak 75% lansia mengalami stress sedang, alasan stress disebabkan oleh kegiatan yang monoton sebanyak 80%. Solusi terhadap masalah itu adalah dilakukannya pemberdayaan lansia dalam sehat lansia dengan tanaman obat keluaraga (TOGA). Metode pada PKM ini yaitu sosialisasi untuk meningkatkan pengetahuan lansia dan tahap selanjutnya dilakukan pendampingan dalam menanam TOGA tersebut. Lansia juga diberikan modul untuk membantu mereka mengetahui manfaat TOGA yang mereka tanam. Kegiatan PKM dilakukan di Desa Kebundadap Timur pada bulan Februari-Agustus 2022. Hasil kegiatan pemberdayaan lansia ini berdampak baik yaitu terdapat 90% lansia yang tingkat stresnya ringan karena melakukan kegiatan menanam TOGA.
Pemanfaatan Maggot Untuk Pengolahan Sampah Organik Di Kecamatan Kedungkandang, Kota Malang
Authors: Tantalu Lorine , Supartini Nonok , Indawan Edyson , Ahmadi Kgs
Published: September 2023

Pupa Maggot memiliki potensi yang luar biasa dalam pengelolaan Sampah Organik Dapur (SOD). Sebagai bentuk kerjasama dengan pengelola Bank Sampah M-230 di Kelurahan Cemorokandang, Kecamatan kedungkandang Kota Malang, peneliti dalam hal ini membantu pewujudkan redesign kandang budidaya lalat black soldier sebagai bagian dari indukan dalam siklus budidaya maggot yang terkendala adanya kerusakan kandang. Sebagai bentuk implementasi terkait kepeduluan terhadap pengurangan timbunan sampah organik dapur, peneliti besama pemilik Bank Sampah M-230 memberikan pemahaman terkait penggunaan tong dekomposer dengan memanfaatkan maggot untuk melakukan biokonversi sampah organik menjadi lebih ramah lingkungan, sekaligus memberikan tong dekomposer kepada perwakilan POKJA. Hasil dari pengelolaan sampah menggunakan maggot ini dapat juga dapat diaplikasikan menjadi pupuk organik yang dapat diterapkan pada tanaman rumah tangga yang dimiliki di lingkungan Kelurahan Cemorokandang tersebut.
Pembelajaran Bahasa Indonesia Pada Anak Down Syndrome Di Lembaga Kesejahteraan Sosial (LKS) Darul Azhar Karangploso
Authors: Lestari Erma , Pravitha Cattleya Wahyu , Kamhar Muhammad Yusi , Tama Triadi , Lestari Rizky
Published: September 2023

Pembelajaran berbahasa Indonesia penting untuk dipelajari oleh setiap warga negara Indonesia, tanpa mengenal usia, asal wilayah, dan kondisi fisik serta mental. Perbedaan fisik dan mental yang disebut dengan istilah anak berkebutuhan khusus memiliki hak yang sama dalam mendapatkan pelayanan pendidikan, namun berbeda dengan kondisi real di LKS Darul Azhar Karangploso. Anak-anak di lembaga tersebut belum mendapatkan pelayanan pembelajaran maksimal, hal ini dibuktikan dengan anak-anak belum dapat membaca menulis, bahkan berbicarapun sangat sulit. Hal ini tentu menjadi faktor utama adalah minimnya SDM dan perhatian dari pihak pengelola. Pendampingan pembelajaran Bahasa Indonesia oleh tim abdimas Unmer Malang sebagai langkah untuk memberikan perhatian kepada masyarakat. Pengabdian fokus pada anak-anak berkebutuhan khusus di lingkungan LKS Darul Azhar Karangploso yang masih minimnya perhatian. Berdasarkan kondisi sosial tersebut, tim abdimas memandang kegiatan pendampingan pembelajaran ini penting dilakukan untuk memberikan pengalaman belajar. Hal ini dilakukan dengan harapan anak-anak berkebutuhan khusus seperti down syndrome dapat beradaptasi dan survive di semua tantangan hidupnya kelak. Kegiatan pendampingan pembelajaran Bahasa Indonesia dilakukan melalui empat tahapan. Pertama, tim abdimas melakukan observasi awal dengan tujuan untuk menggali informasi terkait dengan tingkat penguasaan anak-anak ABK terhadap keterampilan berbahasa. Kedua, tim abdimas akan melakukan penyusunan skema kegiatan yang dibutuhkan saat pengabdian dilakukan. Ketiga, tim abdimas melaksanakan kegiatan pendampingan, dan keempat tim abdimas akan melakukan evaluasi hasil kegiatan yang telah dilaksanakan dan hasil evaluasi dijadikan sebagai pijakan bagi tim abdimas untuk menentukan tindakan lanjutan. Melalui tiga tahapan tersebut tim abdimas melihat ada kemajuan berbahasa Indonesia.
Pelatihan Pembuatan Cabai Bubuk Sebagai Upaya Meningkatkan Potensi Olahan Cabai Dan Meningkatkan Keterampilan Badan Usaha Milik Desa Dan Kelompok Kerja Desa Gunungrejo, Kecamatan Singosari, Kabupaten Malang
Authors: Indira Ida Ayu Putri , Sabilla Rizky Ayu , Shafarudin Tsary Haniya , Pramudya Mohamad Syah Dafa
Published: September 2023

Desa Gunungrejo terletak di Kecamatan Singosari, Kabupaten Malang, Provinsi Jawa Timur. Mayoritas penduduk Desa Gunungrejo mempunyai mata pencaharian sebagai petani. Salah satu komoditas yang memiliki potensi untuk dikembangkan adalah tanaman cabai rawit. Terdapat permasalahan terkait Sumber Daya Manusia (SDM) yang terbatas dapat dilihat dari rendahnya produktivitas pengolahan komoditas yang ada. Masyarakat cenderung konsumtif dan kurang memaksimalkan sektor ekonomi kreatif terlihat dari ketersediaan UMKM yang sedikit. Sebelum diadakannya kegiatan mengenai penanggulangan permasalahan tersebut, mahasiswa KKN-T melakukan survei dan diskusi terkait pengolahan pada komoditas cabai rawit menjadi produk yang memiliki daya simpan lebih lama dan memiliiki nilai ekonomis yang lebih tinggi. Beberapa program pemberdayaan yang dilakukan diawali dengan mengadakan persiapan, penyuluhan pelatihan pengolahan, dan pengemasan cabai rawit segar menjadi produk berupa cabai bubuk, serta pelabelan yang sesuai dengan produk. Program ini bertujuan untuk meningkatkan keterampilan masyarakat dalam mengolah cabai rawit, mengurangi resiko terjadinya kerugian saat harga cabai rawit mengalami penurunan yang cukup siginifikan, dan menjadikan usaha sampingan sehingga dapat meningkatkan penghasilan warga desa.
Peningkatan Kesiapsiagaan Masyarakat Mane Kareung, Kecamatan Blang Mangat, Kota Lhokseumawe dalam Menghadapi Bencana Banjir
Authors: Utariningsih Wheny , Qaristy Hafiza , Khairunnisa Dila , Novalia Vera , Saifullah T.
Published: September 2023

Permasalahan banjir di Desa Mane Kareung terjadi setiap tahun di musim penghujan. Meskipun sering terjadi banjir dan sering mengakibatkan masyarakat harus mengungsi, permasalahan yang terjadi dalam bencana adalah masih rendahnya pencegahan yang dilakukan. Permasalahan tersebut didukung oleh anggapan masyarakat bahwa yang menjadi penanggungjawab penuh atas kejadian bencana adalah pemerintah. Setelah berdiskusi dengan pihak Desa Mane Kareung yang diwakili oleh Keuchik disimpulkan bahwa Desa Mane Kareung yang merupakan desa dengan risiko bencana tinggi yang belum mendapatkan penyuluhan tentang bencana banjir. Oleh karena itu perlu dilaksanakan upaya dalam meningkatkan kesiapsiagaan masyarakat dalam menghadapi bencana banjir. Secara umum tujuan pengabdian kepada masyarakat ini adalah untuk meningkatkan pengetahuan masyarakat serta rencana tanggap darurat masyarakat Desa Mane Kareung ketika terjadi bencana banjir agar dapat meningkatkan kesiapsiagaan masyarakat. Pelaksanaan kegiatan penyuluhan ini dengan ceramah menggunakan metode pendekatan berbasis masyarakat, komprehensif dan partisipatif. Luaran dari kegiatan pengabdian ini adalah meningkatnya pengetahuan masyarakat Desa Mane Kareung tentang bencana banjir dan meningkatnya kesiapsiagaan masyarakat dalam menghadapi bencana banjir.
Pemetaan Potensi UMKM Desa Kucur dan Pendampingan Strategi Pemasaran Produk di Komunitas Klinik Usaha Desa Kucur
Authors: Widyaningrum Santi , Cahyadi Rino Tam
Published: September 2023

Usaha Mikro, Kecil dan Menengah (UMKM) memiliki kontribusi besar dalam menopang perekonomian daerah di Indonesia. Salah satu daerah yang menjadi fokus pengabdian adalah Desa Kucur di Kabupaten Malang karena berdasarkan RPJM-DES, kondisi UMKM di Desa Kucur membutuhkan pendampingan, pengembangan dan pemberian pelatihan untuk meningkatkan kualitas operasional UMKM. Tahun 2021 Desa Kucur membentuk komunitas pelaku usaha yang disebut Klinik Usaha dengan tujuan agar warga Desa Kucur dapat memperoleh pelatihan dan pendampingan pengembangan UMKM. Pada kesempatan ini, tim abdimas berkolaborasi dengan komunitas Klinik Usaha membuat pemetaan potensi usaha Desa Kucur dan sosialisasi teknik pemasaran bagi pelaku UMKM di sana. Diawali dengan forum group discussion (FGD) secara mendalam dengan Ibu Wiwin selaku Ketua Komunitas Klinik Usaha Desa Kucur kemudian dilakukan profiling peserta komunitas dan diketahui terdapat 11 UMKM dari perwakilan dusun Klaseman, Klampok, dan Krajan di komunitas Klinik Usaha Desa Kucur dengan kondisi 90% UMKM tergolong industri Mikro, 50% belum memiliki ijin legalitas usaha, dan pemenuhan sumber daya produksi dan permodalan berasal dari lingkungan setempat. Dari 11 UMKM tersebut hanya 27% yang memperluas pasar ke luar kota serta hanya 18% yang melakukan pencatatan keuangan secara rutin. Pengetahuan tentang strategi pemasaran terutama mengenai e-marketing juga lemah. Dengan permasalahan tersebut diperlukan pelatihan dan pendampingan lanjutan tentang pengelolaan usaha UMKM khususnya dari bidang yang menjadi kelemahan pelaku UMKM di Desa Kucur saat ini, seperti tentang literasi keuangan, strategi penetapan harga, serta aplikasi digital marketing.
PENGARUH KOMPENSASI FINANSIAL TERHADAP LOYALITAS KARYAWAN DENGAN KOMITMEN ORGANISASIONAL SEBAGAI VARIABEL MEDIASI
Authors: Karim Jichan Zairah M. Nur , Jabid Abdullah W , Kamis Ruslan A
Published: September 2023

ABSTRACTObjective: This study aims to determine the effect of financial compensation on loyalty through organizational commitment. This research is a type of quantitative research, because the research method is based on positivistic (concrete data), the research data is in the form of numbers that will be measured using statistics as a means of calculating the test to produce a certain conclusion. The population in this study were all employees of PT. Rum Timur Raya has 100 employees who are still actively working.Methodology: The data analysis method used is multiple linear regression using the SPSS 20.0 program. and the Partial Least Square (PLS) approach using the SmartPLS 3.8 statistical program.Finding: The first, second, third, and fourth (H) hypotheses were accepted because the t statistic value was greater than t table, and the p value was smaller than alpha 0.05.Conclusion: The results of this study indicate that: (1) Financial Compensation has a positive and significant effect on Employee Loyalty; (2) Financial Compensation has a positive and significant effect on organizational commitment; (3) Organizational Commitment has a positive and significant effect on Employee Loyalty; and (4) organizational commitment capable of mediating is able to mediate the effect of financial compensation on employee loyalty is significant, because the t statistic is greater than t table.
ANATOMY OF THE ENDEMIC ALYSSUM PATERI SUBSP. PATERI
Authors: YAYLA Şeyda , HÜRKUL Muhammed Mesud
Published: September 2023

Objective: Alyssum pateri Nyár. subsp. pateri is an endemic plant known as "kanatlı kevke" in Türkiye. The plant is perennial and in semi-shrub form. The plant is traditionally used externally in the treatment of rheumatism in Bingöl (Türkiye). Microscopic analysis of the anatomical structures of plants can provide useful information for taxonomic classification. Light microscopy analysis is a widely used and effective method for the identification of medicinal plants. In this study, the anatomical features of the A. pateri subsp. pateri were examined.
Material and Method: The plant material was collected from Ankara (Türkiye). The samples were protected in 70% alcohol. The cross and surface sections were cut by hand with a razor blade into microscopic preparation form. A Leica DM 4000B microscope was used for anatomical analysis and micro photographs.
Result and Discussion: The anatomical characters of the leaf, petiole and stem of the Alyssum pateri subsp. pateri were revealed. The leaf is dorsiventral and contains 1-2 rows of palisade parenchyma. Cruciferous stomata and stellate hairs are located on the lower epidermis. The petiole cross-section is sulcate and stellate hairs are observed in the epidermal layer. The main vein is arc-shaped and is accompanied by lateral veins. The stem is disc-shaped. Stem epidermis contains stellate hairs. The interfascicular tissue between the xylem strands of the vascular bundles is composed lignified cells. Vascular bundles are surrounded by a pericyclic sclerenchymatous cap.
The Effect of Using E-WoHealth on Knowledge, Attitudes and Behaviors About Body Image and Anemia in Young Women
Authors: Ishak Fadlun , Sanusi Baso Yusring , Ahmad Mardiana , Nilawati Usman Andi , Soraya Riu Deviana , Tamar Muhammad
Published: September 2023

The prevalence of anemia in adolescents in Indonesia has increased by 32%, meaning that 3-4 out of 10 adolescents suffer from anemia in the age group 15-24 years is the largest proportion who experience anemia. This research uses the Combined Method (Research and Development), and the research design uses pre-experimental. The research design develops and validates learning media, namely E-WoHealth, in several stages: analysis of learning media needs, learning media development, design, expert test validation, TAM test, and tininal product of media. The development stage starts with an analysis of the needs of students at Junior High School, Six Gorontalo City. The findings show that the pre-test and post-test values for knowledge, attitudes, and behavior of young women have increased significantly, with a p-value of 0.000 <0.05, meaning that there are differences in the knowledge, attitudes, and behavior of young women before and after being educated using E-WoHealth. In conclusion, web-based E-WoHealth has an effect on the knowledge, attitudes, and behavior of young women regarding body image and anemia. Video and e-modules can be used as alternative educational media to prevent health problems in adolescents, especially anemia. They can improve the habits or behavior of adolescents by assessing themselves by comparing themselves with others to create self-confidence or body image. Positive for teenagers. It is hoped that schools can apply various methods, one of which is the use of animated videos and e-modules that can be accessed using smartphones.
The Influence of Selenium on Telomere Length and DNA Damage as Indicators of Age-Related Changes: A Systematic Literature Review
Authors: Bohari  , Mujahidah Fatimah Fitriani , Susilowati Erna , Marhamah Marhamah , Rimbawan Rimbawan
Published: September 2023

The study aimed to analyze the relationship of selenium to telomere length and DNA damage that reflect aging-related changes at the genome and cellular level. This study used the Systematic Literature Review method to summarize evidence regarding the potential of selenium as an anti-aging agent. It was conducted in April and May 2023. The initial stage was to identify research questions consisting of PICO (Population, Intervention, Comparator, and Outcome). The population involved adults and intervened with selenium, did not use a comparator, and used non-epigenetic biomarker outcomes, namely telomere length and DNA damage which reflect aging-related changes at the genome and cellular level. The reviews were obtained from various countries, including Sweden, France, the United States, Australia, and Brazil. The research subjects used were also diverse and at wide intervals, ranging from young people (20-30 years) to adults (> 70 years). A total of 4 of the 7 studies used a cross-sectional study scheme, 1 case-control, and 2 used an experimental design. Adequate selenium intake can potentially affect telomere length and telomere length maintenance. However, the relationship between selenium and telomere length can be affected by other factors, such as the individual's age and health conditions. Selenium intake may be an important factor in maintaining telomere length and preventing age-related diseases.  Selenium supplementation may be beneficial for people with low selenium levels or who are at risk of age-related diseases. Further research is needed to confirm the findings of this study and to determine the optimal dose of selenium for maintaining telomere length.
The Prone Position Improves the Oxygenation Status of Patients with COVID-19 (Systematic Review-Meta Analysis)
Authors: Rohwandi Rohmat , Rumahorbo Hotma , Lindayani Linlin , Susilawati Susilawati , Badrujamaludin Asep
Published: September 2023

Hypoxemia in Corona Virus 19 patients requires supportive and rehabilitative treatment. PP is a technique that is considered to be safe for improving patient oxygenation. This review aimed to determine a cumulative effect of PP on oxygenation status in COVID-19 patients.The method used The search was carried out independently and systematically on the ProQuest, PubMed, Science Direct, Google Scholar and Semantic Scholar databases from January 2020, until June 2022.  Article screening was carried out through 3 stages: screening duplicate articles, titles and abstracts, and full-text screening by the expected criteria with preferred Items for PRISMA Standards. The quality assessment of the article uses the Joanna Briggs Institute (JBI) checklist form and the Review Manager software. The results A total of 323 articles were evaluated using an RCT or Quasi Experiment design with a control group. It was found that PP had an influence on changes in the value of the ROX index, PaO2/ FiO2 Ratio, SPO2, and SaO2 / FiO2 Ratio with p-value 0.05. Qualitatively, several positive results were obtained from the synthesis of each research. PP was assessed using a ventilation-perfusion matching mechanism in increasing oxygenation and preventing lung injuries.It is concluded that  PP was considered safe even though it caused side effects but it could still be done with good monitoring from health providers.
Novel therapeutics and emerging technology in haemostasis and thrombosis: highlights from the British society for haemostasis and thrombosis annual meeting
Authors: Whyte Claire S. , Morrow Gael B. , Gauer Julia S. , Montague Samantha J. , Nicolson Philip L. R.
Published: September 2023

The 2023 annual meeting of the British Society for Haemostasis and Thrombosis (BSHT) was held in Birmingham, United Kingdom. The theme of this year's meeting was novel therapeutics and emerging technology. Here, the exciting research presented at the meeting is discussed.
In vivo tracking transplanted cardiomyocytes derived from human induced pluripotent stem cells using nuclear medicine imaging
Authors: Saito Yukihiro , Nose Naoko , Iida Toshihiro , Akazawa Kaoru , Kanno Takayuki , Fujimoto Yuki , Sasaki Takanori , Akehi Masaru , Higuchi Takahiro , Akagi Satoshi , Yoshida Masashi , Miyoshi Toru , Ito Hiroshi , Nakamura Kazufumi
Published: September 2023

Introduction

Transplantation of human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) is a promising treatment for heart failure. Information on long-term cell engraftment after transplantation is clinically important. However, clinically applicable evaluation methods have not yet been established.

Methods

In this study, to noninvasively assess transplanted cell engraftment, human SLC5A5, which encodes a sodium/iodide symporter (NIS) that transports radioactive tracers such as 125I, 18F-tetrafluoroborate (TFB), and 99mTc-pertechnetate (99mTcO4−), was transduced into human induced pluripotent stem cells (iPSCs), and nuclear medicine imaging was used to track engrafted human iPSC-CMs.

Results

To evaluate the pluripotency of NIS-expressing human iPSCs, they were subcutaneously transplanted into immunodeficient rats. Teratomas were detected by 99mTcO4− single photon emission computed tomography (SPECT/CT) imaging. NIS expression and the uptake ability of 125I were maintained in purified human iPSC-CMs. NIS-expressing human iPSC-CMs transplanted into immunodeficient rats could be detected over time using 99mTcO4− SPECT/CT imaging. Unexpectedly, NIS expression affected cell proliferation of human iPSCs and iPSC-derived cells.

Discussion

Such functionally designed iPSC-CMs have potential clinical applications as a noninvasive method of grafted cell evaluation, but further studies are needed to determine the effects of NIS transduction on cellular characteristics and functions.
Short-interval second ejaculation improves sperm quality, blastocyst formation in oligoasthenozoospermic males in ICSI cycles: a time-lapse sibling oocytes study
Authors: Li Yaoxuan , Wang Shikai , Li Dawen , Huang Yueyue , Liu Haifang , Zhang Xiaohui , Qin Jie , Mao Xianbao , Li Zhengda , Chen Liangshi , Wei Pingpin , Shi Wen , Xue Lintao
Published: September 2023

Background

Does short-interval second ejaculation improve sperm quality, embryo development and clinical outcomes for oligoasthenozoospermia males received intracytoplasmic sperm injection (ICSI) treatment?

Methods

All enrolled male patients underwent short-interval secondary ejaculation on the day of oocyte retrieval, and 786 sibling MII oocytes from 67 cycles were equally divided into two groups based on whether the injected spermatozoons originated from the first or second ejaculation. Semen parameters, embryo development efficiency, morphokinetic parameters and clinical outcomes were compared between the two groups to assess the efficiency and clinical value of short-interval second ejaculation in ICSI cycles.

Results

Short-interval second ejaculation significantly improved sperm motility, normal morphological rate, and sperm DNA integrity both before and after sperm swim-up. The high-quality blastocyst rate (24.79% versus 14.67%), available blastocyst rate (57.56% versus 48.44%), and oocyte utilization rate (52.93% versus 45.29%) were significantly higher in the second ejaculation group (P<0.05). The clinical pregnancy rate (59.09% versus 47.37%), implantation rate (42.11% versus 32.35%) and live birth rate (40.91% versus 31.58%) were higher in the second ejaculation group, but the differences were not significant (P>0.05). Time-lapse analysis showed that morphokinetic time points after the 7-cell stage were earlier in the second ejaculation group but without a significant difference (P>0.05), and abnormal embryo cleavage patterns between the two groups were not significantly different (P>0.05).

Conclusions

Short-interval second ejaculation significantly improves sperm quality in oligoasthenozoospermic males, and is beneficial for blastocyst formation efficiency in ICSI cycles. This study suggested a non-invasive and simple but effective strategy for improving ICSI treatment outcomes.
Opportunities and challenges of converging technology and blended finance for REDD+ implementation
Authors: Jang Eun-Kyung , Kwak Dongheon , Choi Gayoung , Moon Jooyeon
Published: September 2023

The importance of Reducing Emissions from Deforestation and Forest Degradation (REDD+) has been elevated within the new climate framework outlined by the Paris Agreement, placing a significant emphasis on encouraging nations to adopt and promote REDD+ strategies. The success of REDD+ is highly dependent on financial resources that aid in addressing and mitigating the primary causes of deforestation and forest degradation. Furthermore, REDD+ projects utilize technology to counter challenges such as land-use changes for agriculture, infrastructure development, illegal logging, fuelwood collection, and forest fires. This study investigates the status of REDD+ projects, which are aimed at combating global deforestation and climate change, supported by the Climate Technology Center Network (CTCN) and the Green Climate Fund (GCF), both of which are critical mechanisms under the United Nations Framework Convention on Climate Change (UNFCCC). We examined these projects through the lenses of technology convergence and finance blending. The analysis revealed that the CTCN and GCF predominantly support projects leveraging technology for forest disaster management. In addition, the agricultural sector demonstrated the highest degree of technology convergence. The findings indicate that a strategic approach for securing private funding involves integrating mitigation and adaptation efforts in projects. Furthermore, partnerships can facilitate the blending of financial strategies to mitigate risks. The study highlights the potential of technology convergence in enhancing the feasibility of scaling up REDD+ projects by promoting stakeholder engagement and catalyzing the private capital influx.
Case report: genetic analysis of a novel frameshift mutation in FMR1 gene in a Chinese family
Authors: Jin Chunlei , Zhang Xiangdong , Lei Qiang , Chen Penglong , Hu Hui , Shen Shuangshuang , Liu Jiao , Ye Shixuanbao
Published: September 2023

Fragile X syndrome (FXS) [OMIM 300624] is a common X-linked inherited syndrome with an incidence only second to that of trisomy 21. More than 95% of fragile X syndrome is caused by reduced or absent fragile X intellectual disability protein 1 (FMRP) synthesis due to dynamic mutation expansion of the CGG triplet repeat in the 5′UTR and abnormal methylation of the FMR1 (fragile X messenger ribonucleoprotein 1) gene [OMIM 309550]. Less than 5% of cases are caused by abnormal function of the FMRP due to point mutations or deletions in the FMR1 gene. In a proband with clinical suspicion of FXS and no CGG duplication, we found the presence of c.585_586del (p.Lys195AsnfsTer8) in exon 7 of the FMR1 gene using whole exome sequencing (WES). This variant resulted in frameshift and a premature stop codon after 8 aberrant amino acids. This variant is a novel pathogenic mutation, as determined by pedigree analysis, which has not been reported in any database or literature.
The mechanisms and factors that induce trained immunity in arthropods and mollusks
Authors: Zhao Mingming , Lin Zhongyang , Zheng Zhihong , Yao Defu , Yang Shen , Zhao Yongzhen , Chen Xiuli , Aweya Jude Juventus , Zhang Yueling
Published: September 2023

Besides dividing the organism’s immune system into adaptive and innate immunity, it has long been thought that only adaptive immunity can establish immune memory. However, many studies have shown that innate immunity can also build immunological memory through epigenetic reprogramming and modifications to resist pathogens’ reinfection, known as trained immunity. This paper reviews the role of mitochondrial metabolism and epigenetic modifications and describes the molecular foundation in the trained immunity of arthropods and mollusks. Mitochondrial metabolism and epigenetic modifications complement each other and play a key role in trained immunity.
Novel bimodal TRBD1-TRBD2 rearrangements with dual or absent D-region contribute to TRB V-(D)-J combinatorial diversity
Authors: Smirnova Anastasia O. , Miroshnichenkova Anna M. , Belyaeva Laima D. , Kelmanson Ilya V. , Lebedev Yuri B. , Mamedov Ilgar Z. , Chudakov Dmitriy M. , Komkov Alexander Y.
Published: September 2023

T-cell receptor (TR) diversity of the variable domains is generated by recombination of both the alpha (TRA) and beta (TRB) chains. The textbook process of TRB chain production starts with TRBD and TRBJ gene rearrangement, followed by the rearrangement of a TRBV gene to the partially rearranged D-J gene. Unsuccessful V-D-J TRB rearrangements lead to apoptosis of the cell. Here, we performed deep sequencing of the poorly explored pool of partial TRBD1-TRBD2 rearrangements in T-cell genomic DNA. We reconstructed full repertoires of human partial TRBD1-TRBD2 rearrangements using novel sequencing and validated them by detecting V-D-J recombination-specific byproducts: excision circles containing the recombination signal (RS) joint 5’D2-RS – 3’D1-RS. Identified rearrangements were in compliance with the classical 12/23 rule, common for humans, rats, and mice and contained typical V-D-J recombination footprints. Interestingly, we detected a bimodal distribution of D-D junctions indicating two active recombination sites producing long and short D-D rearrangements. Long TRB D-D rearrangements with two D-regions are coding joints D1-D2 remaining classically on the chromosome. The short TRB D-D rearrangements with no D-region are signal joints, the coding joint D1-D2 being excised from the chromosome. They both contribute to the TRB V-(D)-J combinatorial diversity. Indeed, short D-D rearrangements may be followed by direct V-J2 recombination. Long D-D rearrangements may recombine further with J2 and V genes forming partial D1-D2-J2 and then complete V-D1-D2-J2 rearrangement. Productive TRB V-D1-D2-J2 chains are present and expressed in thousands of clones of human antigen-experienced memory T cells proving their capacity for antigen recognition and actual participation in the immune response.
Low-intensity pulsed ultrasound of different intensities differently affects myocardial ischemia/reperfusion injury by modulating cardiac oxidative stress and inflammatory reaction
Authors: Cao Quan , Liu Lian , Hu Yugang , Cao Sheng , Tan Tuantuan , Huang Xin , Deng Qing , Chen Jinling , Guo Ruiqiang , Zhou Qing
Published: September 2023

Introduction

The prevalence of ischemic heart disease has reached pandemic levels worldwide. Early revascularization is currently the most effective therapy for ischemic heart diseases but paradoxically induces myocardial ischemia/reperfusion (MI/R) injury. Cardiac inflammatory reaction and oxidative stress are primarily involved in the pathology of MI/R injury. Low-intensity pulsed ultrasound (LIPUS) has been demonstrated to reduce cell injury by protecting against inflammatory reaction and oxidative stress in many diseases, including cardiovascular diseases, but rarely on MI/R injury.

Methods

This study was designed to clarify whether LIPUS alleviates MI/R injury by alleviating inflammatory reaction and oxidative stress. Simultaneously, we have also tried to confirm which intensity of the LIPUS might be more suitable to ameliorate the MI/R injury, as well as to clarify the signaling mechanisms. MI/R and simulated ischemia/reperfusion (SI/R) were respectively induced in Sprague Dawley rats and human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs). LIPUS treatment, biochemical measurements, cell death assay, estimation of cardiac oxidative stress and inflammatory reaction, and protein detections by western blotting were performed according to the protocol.

Results

In our study, both in vivo and in vitro, LIPUS of 0.1 W/cm2 (LIPUS0.1) and 0.5 W/cm2 (LIPUS0.5) make no significant difference in the cardiomyocytes under normoxic condition. Under the hypoxic condition, MI/R injury, inflammatory reaction, and oxidative stress were partially ameliorated by LIPUS0.5 but were significantly aggravated by LIPUS of 2.5 W/cm2 (LIPUS2.5) both in vivo and in vitro. The activation of the apoptosis signal-regulating kinase 1 (ASK1)/c-Jun N-terminal kinase (JNK) pathway in cardiomyocytes with MI/R injury was partly rectified LIPUS0.5 both in vivo and in vitro.

Conclusion

Our study firstly demonstrated that LIPUS of different intensities differently affects MI/R injury by regulating cardiac inflammatory reaction and oxidative stress. Modulations on the ASK1/JNK pathway are the signaling mechanism by which LIPUS0.5 exerts cardioprotective effects. LIPUS0.5 is promising for clinical translation in protecting against MI/R injury. This will be great welfare for patients suffering from MI/R injury.
Increased gut permeability and bacterial translocation are associated with fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome: implications for disease-related biomarker discovery
Authors: Martín Franz , Blanco-Suárez Manuel , Zambrano Paola , Cáceres Oscar , Almirall Miriam , Alegre-Martín José , Lobo Beatriz , González-Castro Ana Maria , Santos Javier , Domingo Joan Carles , Jurek Joanna , Castro-Marrero Jesús
Published: September 2023

Background

There is growing evidence of the significance of gastrointestinal complaints in the impairment of the intestinal mucosal barrier function and inflammation in fibromyalgia (FM) and in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). However, data on intestinal permeability and gut barrier dysfunction in FM and ME/CFS are still limited with conflicting results. This study aimed to assess circulating biomarkers potentially related to intestinal barrier dysfunction and bacterial translocation and their association with self-reported symptoms in these conditions.

Methods

A pilot multicenter, cross-sectional cohort study with consecutive enrolment of 22 patients with FM, 30 with ME/CFS and 26 matched healthy controls. Plasma levels of anti-beta-lactoglobulin antibodies (IgG anti-β-LGB), zonulin-1 (ZO-1), lipopolysaccharides (LPS), soluble CD14 (sCD14) and interleukin-1-beta (IL-1β) were assayed using ELISA. Demographic and clinical characteristics of the participants were recorded using validated self-reported outcome measures. The diagnostic accuracy of each biomarker was assessed using the receiver operating characteristic (ROC) curve analysis.

Results

FM patients had significantly higher levels of anti-β-LGB, ZO-1, LPS, and sCD14 than healthy controls (all P < 0.0001). In ME/CFS patients, levels of anti-β-LGB, ZO-1, LPS, and sCD14 were significantly higher than controls, but lower than in FM (all P < 0.01), while there was no significant difference in IL-1β level. In the FM and ME/CFS cohorts, both anti-β-LGB and ZO-1 correlated significantly with LPS and sCD14 (P < 0.001 for both). In the FM group, both anti-β-LGB and ZO-1 were correlated significantly with physical and mental health components on the SF-36 scale (P < 0.05); whereas IL-1β negatively correlated with the COMPASS-31 score (P < 0.05). In the ME/CFS cohort, ZO-1 was positively correlated with the COMPASS-31 score (P < 0.05). The ROC curve analysis indicated a strong ability of anti-β-LGB, ZO-1, LPS and sCD14 to predictively distinguish between FM and ME/CFS from healthy controls (P < 0.0001).

Conclusion

Biomarkers of intestinal barrier function and inflammation were associated with autonomic dysfunction assessed by COMPASS-31 scores in FM and ME/CFS respectively. Anti-β-LGB antibodies, ZO-1, LPS, and sCD14 may be putative predictors of intestinal barrier dysfunction in these cohorts. Further studies are needed to assess whether these findings are causal and can therefore be applied in clinical practice.
Genetic investigation of Nordic patients with complement-mediated kidney diseases
Authors: Rydberg Viktor , Aradottir Sigridur Sunna , Kristoffersson Ann-Charlotte , Svitacheva Naila , Karpman Diana
Published: September 2023

Background

Complement activation in atypical hemolytic uremic syndrome (aHUS), C3 glomerulonephropathy (C3G) and immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN) may be associated with rare genetic variants. Here we describe gene variants in the Swedish and Norwegian populations.

Methods

Patients with these diagnoses (N=141) were referred for genetic screening. Sanger or next-generation sequencing were performed to identify genetic variants in 16 genes associated with these conditions. Nonsynonymous genetic variants are described when they have a minor allele frequency of <1% or were previously reported as being disease-associated.

Results

In patients with aHUS (n=94, one also had IC-MPGN) 68 different genetic variants or deletions were identified in 60 patients, of which 18 were novel. Thirty-two patients had more than one genetic variant. In patients with C3G (n=40) 29 genetic variants, deletions or duplications were identified in 15 patients, of which 9 were novel. Eight patients had more than one variant. In patients with IC-MPGN (n=7) five genetic variants were identified in five patients. Factor H variants were the most frequent in aHUS and C3 variants in C3G. Seventeen variants occurred in more than one condition.

Conclusion

Genetic screening of patients with aHUS, C3G and IC-MPGN is of paramount importance for diagnostics and treatment. In this study, we describe genetic assessment of Nordic patients in which 26 novel variants were found.
High efficiency dye-sensitized solar cells with a novel two dimensional Cd-V-LDH photoanode
Authors: Bendary Samar H. , Hashem Amira A. , Mahmoud Sawsan A.
Published: September 2023

The present study demonstrates a novel photoanode layer double hydroxide (LDH) for dye-sensitized solar cells (DSSCs). The search for a photoanode (PA) with low cost and high power conversion efficiency (PCE) has become one of the most significant challenges facing researchers. LDH has proven successful as a photocatalyst in various fields. In this paper, a novel Cd-V-LDH with a molar ratio of Cd:V = 1:1 was synthesized by the coprecipitation method and used as a novel PA in DSSCS. X-ray diffraction (XRD), Raman spectroscopy, Scanning electron microscopy (SEM), Fourier Transform infrared spectroscopy (FTIR), Nitrogen sorption analysis, UV–Vis absorption spectrum, Electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) were used to examine the produced Cd-V-LDH. Cd-V-LDH as PA, Eosin Y (EY) as a photosensitizer, LiI-I2 as a liquid electrolyte, and g-C3N4 (GN) as a photocathode (PC) are the component of DSSCs. The series cells of DSSCs were assembled and the available variables have been studied to achieve the best performance under normal conditions. These variables, e.g., concentration and pH of EY, active area of PA, and different types of PC, e.g., graphene oxide (GO), commercial carbon (CC), and (GN). The open circuit voltage (VOC) and short circuit current density (JSC) for the Cd-V-LDH/EY/LiI-I2/GN system were observed to be 705 mV and 12.40 mA/cm2, and has a PCE of 5.4% comparable to Cd-V-LDH/EY/LiI-I2/GO and Cd-V-LDH/EY/LiI-I2/CC, which have PCEs of 4.9% and 3.8%, respectively, in the identical testing conditions.
Case report: A case of acute exacerbation of interstitial pneumonia associated with TAFRO syndrome
Authors: Shimada Yoshitaka , Nagaba Yasushi , Fujino Mako , Okawa Hiroyuki , Ehara Kaori , Shishido Eri , Okada Shinya , Yokomori Hiroaki
Published: September 2023

Cytokine storm caused by the overproduction of inflammatory interleukin (IL)-6 plays a central role in the development of acute inflammation. The extremely rare disease, TAFRO syndrome, progresses quickly. Renal dysfunction, fever, reticulin fibrosis, anasarca, thrombocytopenia, and organomegaly with pathological findings such as idiopathic multicentric Castleman disease are all characteristics of TAFRO syndrome. Interstitial pneumonia (IP), which is not characteristic of this disease, is probably a complication of the inflammatory process. An 88-year-old man presented with a 3-day history of fever, dry cough, and progressive dyspnea. After he was first treated with antibiotics, he was transferred to our hospital because he showed no improvement. Data showed hemoglobin Hb 90.00 (SI) (9.0 g/dL); leukocyte count WBC 23 × 109/L (SI) [23,000/μL (neutrophils 87.5%, lymphocytes 2.5%, blast cells 0%)]; hemoglobin 90 g/L (9.0 g/dL); platelet count 101.00 × 109/L (10 100/μL); lactate dehydrogenase 4.78 μkat/L (286 U/L); serum albumin 25.00 g/L (2.5 g/dL); blood urea nitrogen 18.17 μmol/L (50.9 mg/dL); creatinine 285.53 μmol/L (3.23 mg/dL); C-reactive protein 161.50 mg/L (16.15 mg/dL); IL-61830 pg/mL; and surfactant protein D level 26.6 ng/mL. Findings from computed tomography indicated increased ground-glass opacities without traction bronchiectasis consistent with acute IP. The diagnosis was leukocytosis and progressive kidney injury. After bone marrow aspiration caused by persistent pancytopenia, mild reticulin fibrosis was identified. Because of the high IL-6 concentration, which revealed small atrophic follicles with regressed germinal centers surrounded by several lymphocytes, right inguinal lymph node biopsy was performed. Two minor and three major criteria led to diagnosis of TAFRO syndrome. Administrations of antibiotic therapy and methylprednisolone pulse therapy were ineffective. After rapid progress of respiratory failure, the patient died on day 30 of hospitalization. Autopsy of lung tissues showed diffuse alveolar damage with hyaline membranes. Based on these findings, we diagnosed acute exacerbation of IP associated with TAFRO syndrome due to IL-6 overproduction-associated cytokine storm.