bluuebunny/crossref_metadata_2025 huggingface dataset:
Privacy Aware Data Aggregation with Application in Voting Systems
Authors: Bayat Arash
Published: January 2025

Turning raw data into informative insights is an essential procedure. When data is public, the aggregated information is trusted it can be reproduced. However, it is difficult to achieve trust when the data is private. An obvious example is the voting system where votes are kept in secret, yet everyone needs to trust the count. The problem is to achieve privacy and trust together.Traditional paper-based voting satisfy privacy because the voter's identity is detached from the ballot. However, trust is not satisfied. It relies on the fact that a considerable change in the count requires a large number of election staff to be involved (which is difficult to achieve). Apart from being expensive to perform, post-election protests show that paper-based voting is not trusted as claimed. Paper-based voting remains the only effective solution as it is much more difficult to address privacy-trust problem in electronic voting. Advanced technologies in digital security (i.e. homomorphic encryption, block chain, etc.) have been widely used to address this problem [1,2,3,4,5,6,7,8,9,10,11].This article introduces a novel approach that satisfies both trust and privacy in the aggregation of private data. Tow implementations of the proposed approach for the voting system are also described. In the proposed method, each party encrypts its data and publishes the encrypted data publicly. Aggregation on encrypted data results in decrypted information without the need for decryption process.
Composite Electrolytes for Supercapacitors
Authors: Fu Lijun , Qu Qunting , Liu Lili , Holze Rudolf
Published: January 2025

Composite electrolytes for applications in electrochemical energy technology, i.e. in batteries and supercapacitors, are gaining increasing attention. In the absence of a commonly accepted definition a ternary combination of materials, e.g. a polymer with an electrolyte salt or electrolyte salt solution and a third conductivity-enhancing constituent, is assumed as a definition of a composite electrolyte in the following review. Relevant fundamentals and reported research results up to explanations of the observed effects and improvements are reviewed. Future perspectives and directions of further research are indicated.
Quantitative Assessment of Fixational Disparity Using a Binocular Eye-Tracking Technique in Children with Strabismus
Authors: Hou Xiaoyi , Yang Xubo , Chen Bingjie , Liao Yong Chuan
Published: January 2025

Fixational eye movements are important for holding the central visual field on a target for a certain period. In this study, we aimed to quantitatively assess fixational dispari-ties using binocular eye-tracking in strabismus children (before and after surgical alignment) and normal children. Fixational disparity of 117 children (4 – 18 years; 57 with strabismus and 60 age-similar normal controls) were recorded under binocular viewing with corrected refractive errors. Disparities in gaze positions relative to the target location were recorded from both eyes. Main outcome measures included fixa-tion disparities along horizontal and vertical axes in the fixation test. Children with strabismus exhibited significant (P<0.001) fixational disparities than normal children in both horizontal and vertical directions. Additionally, children with esotropia versus exotropia had poorer fixational function. Fixational disparities were significantly de-creased in the horizontal direction after strabismus surgery. A significant negative correlation was observed between binocular best-corrected visual acuity and fixation disparities in children with strabismus. Children with strabismus had significant fixa-tional disparities that were observably diminished in the horizontal direction after surgical alignment. Binocular assessment of fixational disparities can provide a more comprehensive evaluation of visual function in strabismus
Narrativas de professoras que atuam com a Educação Matemática de Jovens e Adultos
Authors: Freire Paula Silvestre , Vieira André Ricardo Lucas
Published: January 2025

O presente artigo tem como objetivo analisar a inserção da Educação Matemática Crítica nas práticas pedagógicas de professoras que ensinam Matemática na Educação de Jovens e Adultos (EJA). O estudo fundamenta-se na base epistemológica da pesquisa qualitativa em que o sujeito e a realidade formativa são concebidos como indissociáveis. Trata-se de um estudo de caso realizado com três professoras da rede pública do município de Senhor do Bonfim-BA, que atuam no Ensino Médio da modalidade EJA, tendo como dispositivo de recolha de informações, o questionário e a entrevista narrativa. O estudo evidenciou que as professoras encontram dificuldades para trazer a abordagem da Educação Matemática Crítica em suas práticas educativas na sala de aula, o que revela a necessidade de uma formação continuada para que se possa potencializar a dimensão crítica no ensino de Matemática na Educação de Jovens e Adultos.
Efficacy of combination therapy for severe cervical intraepithelial neoplasia
Authors:   Saint Petersburg State Medical University, Saint Petersburg, Russian Federation, Shapovalova E.A. , Shkarupa I.A. ,   Saint Petersburg State Medical University, Saint Petersburg, Russian Federation, Khachaturyan A.R. ,   Saint Petersburg State Medical University, Saint Petersburg, Russian Federation,   D.O.Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine, Saint Petersburg, Russian Federation, Frolova E.S. ,   Saint Petersburg State Medical University, Saint Petersburg, Russian Federation, Zelimkhanova Ya.A. ,   Saint Petersburg State Medical University, Saint Petersburg, Russian Federation, Vinogradova A.N. ,   Saint Petersburg State Medical University, Saint Petersburg, Russian Federation, Savina A.A. ,   Saint Petersburg State Medical University, Saint Petersburg, Russian Federation
Published: January 2025

Objective. To evaluate the long-term efficacy and safety of combination therapy (excision + photodynamic therapy (PDT)) for severe cervical intraepithelial neoplasia (CIN) associated with human papillomavirus (HPV) of high carcinogenic risk (HCR).
Patients and methods. This study presents a retrospective analysis of case histories and outpatient records of 58 women who underwent combination therapy for severe CIN between January 2018 and June 2019. The mean age of patients was 33.1 ± ± 7.3 years. At the first stage, patients underwent large loop excision of the transformation zone (LLETZ, 17.2%) or cone biopsy (82.8%). After 2–3 months, PDT was performed using a chlorin e6-based photosensitizer. Therapy efficacy was evaluated by Co-testing (HPV HCR DNA and cytology of ecto- and endocervical smears) after 3, 6, 12 months, and annually thereafter.
Results. The severity of squamous intraepithelial lesions according to the results of histological examination was distributed as follows: CIN II – 29.3% of cases, CIN III – 69.0%, cancer in situ – 1.7%. A positive resection margin was determined in 44.8% of patients. The overall efficacy of combination therapy (a negative Co-test) was 96.3%: 5 patients underwent two sessions of PDT, 4 patients had persistent HPV infection for a year and a half after one session of PDT, with subsequent elimination. The therapy performed was ineffective in 2 patients, while all women with a positive resection margin had a complete curative
effect. No significant complications were noted during and after therapy. No disease recurrence was detected during a 4-year follow-up.
Conclusion. PDT in combination with diagnostic excision is an effective and safe treatment method for severe CIN associated with HPV, which ensures a long recurrence-free period with continuous follow-up.
Gestagens in pharmacotherapy for endometriosis: pathogenetic rationale, long-term clinical efficacy and safety
Authors:   Patrice Lumumba Peoples’ Friendship University of Russia (RUDN), Moscow, Russian Federation, Orazov M.R. , Radzinsky V.E. ,   Patrice Lumumba Peoples’ Friendship University of Russia (RUDN), Moscow, Russian Federation, Dolgov E.D. ,   Patrice Lumumba Peoples’ Friendship University of Russia (RUDN), Moscow, Russian Federation
Published: January 2025

Endometriosis remains one of the most controversial diseases in modern gynecology. Many new discoveries regarding the pathogenesis of endometriosis raise even more questions in terms of therapeutic approaches to this nosology. According to international and federal guidelines, pharmacotherapy with gestagens is the preferred treatment for symptomatic endometriosis, but these protocols lack data on the specific advantages and disadvantages of such a broad pharmacological group. This review presents the most used gestagens in clinical practice not only from a pharmacological but also from a clinical-pathogenetic perspective to identify the most effective, safe, and prioritized progestin for the long-term treatment of endometriosis.
Key words: endometriosis, gestagens, dienogest, levonorgestrel, norethisterone acetate, medroxyprogesterone acetate, dydrogesterone
Practical realization of chiral nonlinearity for strong topological protection
Authors: Guo Xinxin , Jezequel Lucien , Padlewski Mathieu , Lissek Hervé , Delplace Pierre , Fleury Romain
Published: January 2025

Nonlinear topology has been much less inquired compared to its linear counterpart. Existing advances have focused on nonlinearities of limited magnitudes and fairly homogeneous types. As such, the realizations have rarely been concerned with the requirements for nonlinearity. Here we explore nonlinear topological protection by determining nonlinear rules and demonstrate their relevance in real-world experiments. We take advantage of chiral symmetry and identify the condition for its continuation in general nonlinear environments. Applying it to one-dimensional topological lattices, we show possible evolution paths for zero-energy edge states that preserve topologically nontrivial phases regardless of the specifics of the chiral nonlinearities. Based on an acoustic prototype design with non-local nonlinearities, we theoretically, numerically, and experimentally implement the nonlinear topological edge states that persist in all nonlinear degrees and directions without any frequency shift. Our findings unveil a broad family of nonlinearities compatible with topological non-triviality, establishing a solid ground for future drilling in the emergent field of nonlinear topology.
NEGLECTED SPINAL SUBDURAL HEMATOMA AFTER LUMBAR PUNCTURES FOR INTRATHECAL CHEMOTHERAPY, A CASE REPORT
Authors:   Departement of Neurosurgery, Faculty of Medicine of Agadir, Ibn Zohr University Agadir, Morocco., Benyaich Z. , Jamaleddine El Idrissi A. ,   Departement of Neurosurgery, Faculty of Medicine of Agadir, Ibn Zohr University Agadir, Morocco., Amghar M. ,   Departement of Neurosurgery, Faculty of Medicine of Agadir, Ibn Zohr University Agadir, Morocco., Laffinti N. ,   Departement of Neurosurgery, Faculty of Medicine of Agadir, Ibn Zohr University Agadir, Morocco., Lmejjati M. ,   Departement of Neurosurgery, Faculty of Medicine of Agadir, Ibn Zohr University Agadir, Morocco.
Published: January 2025

Spinal subdural hematoma is a rare complication of lumbar puncture. It could be overlooked with devastating neurological consequences due to a delay in diagnosis. We report the case of 18 years-old woman followed for leukemia who presented a cauda equina syndrome after lumbar punctures for intrathecal chemotherapy. The Magnetic Resonance Imaging showed a thoraco-lumbar spinal subdural hematoma. The treatment consisted on a surgical evacuation of the hematoma after L2 laminectomy. On follow-up, the patient did not improve significantly. This observation shows that haemato-oncologists should be mindful of subdural hematoma as a possible complication of intrathecal chemotherapy and confirms the severity of the prognosis for late surgery.
PEDIATRIC BRAIN TUMORS: INSIGHTS FROM THE RADIOTHERAPY DEPARTMENT AT HASSAN II UNIVERSITY HOSPITAL, FES, MOROCCO
Authors: Wissal Hassani , Ouhaila Kanounin , Samia Khalif , Kaoutar Soussy , Fatima Zahra Farhane , Zenab Alami , Fatouria Bouha
Published: January 2025

Introduction: Pediatric brain tumors are the second most common type of cancer in children, and despite improvements in diagnosis and treatment, they remain a leading cause of cancer-related mortality. This study aims to describe the clinical, epidemiological, and therapeutic characteristics of children treated for brain tumors at Hassan II University Hospital, Fes.

Methods: A retrospective study of 38 children under 15 years old diagnosed with primary brain tumors between January 2013 and December 2022. Data on clinical presentation, tumor type, treatment, and outcomes were analyzed using descriptive statistics. Results: The mean age at diagnosis was 7.37 years, with a male predominance (58%). Most patients presented with intracranial hypertension (78%) and neurological deficits (44%). Medulloblastoma (42.1%) was the most common tumor type. Surgical intervention was performed in all cases, with 55.26% achieving complete resection. Radiotherapy was used in 86%, and chemotherapy in 44.7%. Acute toxicities included nausea and hematological complications, while late effects included cognitive delays and sensory impairments. Remission was achieved in 89.47% of patients within three months, with a 39.47% mortality rate.

Conclusion: While treatment for pediatric brain tumors has improved, the risk of recurrence and long-term complications remains a significant challenge. Early diagnosis and tailored treatment protocols are crucial for improving survival and quality of life in these patients.
TRADITIONAL BEVERAGES TRADING BY USING NATURAL HERBALS AND SPICES IN MADURAI IN TAMILNADU: A STUDY
Authors:   Assistant Professor, Department of History, Mannar Thirumalai Naicker College, Pasumalai, Madurai., Rajagopal S. , Praiya R. ,   Assistant Professor, Department of History, Mannar Thirumalai Naicker College, Pasumalai, Madurai.
Published: January 2025

Cultural heritage city Madurai is famous for its Dravidian style temple but also, renowned for traditional beverages and food. In the modern world, people commonly like more modern delicious cold and hot beverages easily available in the local market. In Madurai city of Tamilnadu state, the traditional drinks Gigarthanda, Paruthi Paal, Sukku Coffee, Melagu Rasam, and Aatukkaal Soup are available in fresh, healthy and nutritious drinks in the local shops and street vendors market. The functional drinks are incorporated with natural herbal medicine and spices materials such as cardamom, pepper, piper jongum, dried ginger, basil seeds, palm jaggery and cotton seeds. The ingredients incorporated in beverages cure the symptoms of cough, cold, headache, pain, vomiting, fever and indigestion issues. So, visitors from inside and outside Madurai in Tamilnadu and international tourists like the local beverages. Traditional beverages of different varieties are very popular and they can be liked by children to old people. Regarding the traditional beverages in Madurai city by using natural herbals and spices, preparation available shops, the cost of the drinks and results we will discuss in detail.
IMPACT OF CLIMATE CHANGE ON REPRODUCTION AND MIGRATION OF CHELONIA MYDAS ALONG THE WEST AFRICAN COAST
Authors:   Higher Institute of Veterinary Sciences and Medicine ISSMV of Dalaba-Guinea, Guinea., Bilivogui Pascal , Konate Daouda ,   Rogbane-Conakry Oceanographic Research Center CERESCOR BP: 1615 Rogbane Conakry, Guinea., Moussa Kamano Saa ,   Rogbane-Conakry Oceanographic Research Center CERESCOR BP: 1615 Rogbane Conakry, Guinea., Diallo Hadiatou ,   Higher Institute of Veterinary Sciences and Medicine ISSMV of Dalaba-Guinea, Guinea., Bangoura Facinet ,   Higher Institute of Veterinary Sciences and Medicine ISSMV of Dalaba-Guinea, Guinea., Seth Camara Kadiatou ,   Higher Institute of Veterinary Sciences and Medicine ISSMV of Dalaba-Guinea, Guinea.
Published: January 2025

In an ever-changing world, the sustainable protection of marine biodiversity along the Guinean coast is a necessity. This work focuses on the current situation of the green turtle (Chelonia mydas) on Katrack Island in Guinea. The aim of this study is to highlight the current situation of the green turtle (Chelonia mydas) on Katrack Island in Guinea. The methodology adopted includes consultation with officials, managers, and fishermen, patrols over a 90-day period, and processing of the collected data. Consultation with officials confirmed the presence of turtles on Katrack Island. Patrols led to the discovery of 33 green turtle nests containing 3,713 eggs, 31 tracks with nests, 13 strandings, 5 accidental captures, one recovered shell, and two tracks without nests. The discovered eggs were transplanted into a monitored enclosure. 2,695 baby turtles hatched after an incubation period of 45 to 60 days. The sex ratio at hatching was 71% female and 29% male. Regarding maturity stages, 64% were sub-adults, 23% adults, and 11% juveniles. These results demonstrate that the Guinean coast is frequently visited by green turtles. However, sustainable protection is necessary to ensure the conservation of this species in the region.
RAISING PERFORMANCE BY INTELLIGENT SUPPLY CHAIN REFORM
Authors: Li Kerui
Published: January 2025

The fourth industrial revolution has created new opportunities for global industries. This dissertation discusses the advantages of supply chain intelligence and proposes a framework for the intelligent supply chain reform of small and medium-sized enterprises (SMEs). The study confirms that the various technologies brought by Industry 4.0 will support the intelligent transformation of supply chains, with particularly significant benefits for SMEs. Given that the adoption of these technologies requires time to develop and mature, NVIVO12 is employed as the analysis software to select and analyze relevant literature from the past decade. This qualitative research applies word frequency analysis, node analysis, and text analysis methods. The dissertation identifies the key goals and directions for intelligent supply chain reform. Finally, it offers suggestions for SMEs reform and outlines potential directions for future research in the field.
EFFECT OF MODIFIED SLOW BREATHING EXERCISE ON PULMONARY FUNCTION IN HEALTHY, ADULT MALES-AN INTERVENTIONAL STUDY
Authors:   Assistant Professor, Dept. of Physiology, AIIMS Mangalagiri., Naik G. Sunil , G.K. Pal ,   Senior Professor, Dept. of Physiology, JIPMER., P. Dipankar Satish ,   Additional Professor, Dept.of Physiology, AIIMS Mangalagiri., G.S Gaur ,   Senior Professor, Dept. of Physiology, JIPMER.
Published: January 2025

Different types of breathing exercise have varied effects on pulmonary function parameters in an individual. To study the effect of a modified Slow breathing exercise on pulmonary function parameters in adult Males.

Settings and Design: This was a randomized control, interventional study carried out at Advanced Centre for Yoga Therapy Education and Research (ACYTER), Department of Physiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry.

Materials and Methods: Hundred healthy, male volunteers were recruited and randomized into control group, n=50 and Modified Slow breathing exercise(study), n=50. Modified Slow breathing exercise training was given to the study group for 30 minutes a day, 5 times/week for a total period of 12 weeks, under supervision of certified yoga trainers. Forced vital capacity (FVC), Forced end expiratory volume at the end of 1 sec (FEV1), FEV1/FVC ratio, Peak expiratory flow rate (PEFR), Forced expiratory flow 25-75% (FEF25-75) were recorded at baseline and after 12 weeks. No intervention was given for control group. Statistical analysis was done using appropriate analytical methods by SPSS software ver.19.0.

Results: FVC, FEV1, FVC/FEV1, PEFR, FEF25-75 decreased significantly (P<0.05) in the study group following 12 weeks of modified Anuloma Viloma pranayama. No significant change was observed in the control group.

Conclusion: Twelve weeks of modified Slow breathing exercise significantly improved the pulmonary function parameters. This indicates that our modified alternate nostril breathing exercise is equally effective in improving the pulmonary function parameters.
LE CARCINOME ADENOSQUAMEUX DE LA PEAU : A PROPOS DUN CAS
Authors:   Service de Chirurgie Plastique Reparatrice de lHopital Militaire Moulay Ismail-Meknes., Kartite D. , Moujahid A. ,   Service de Chirurgie Plastique Reparatrice et des Brules de lHopital Militaire dInstruction Mohamed V-Rabat., Khales A. ,   Service de Chirurgie Plastique Reparatrice et des Brules de lHopital Militaire dInstruction Mohamed V-Rabat., Achbouk A. ,   Service de Chirurgie Plastique Reparatrice et des Brules de lHopital Militaire dInstruction Mohamed V-Rabat., Ribag Y. ,   Service de Chirurgie Plastique Reparatrice et des Brules de lHopital Militaire dInstruction Mohamed V-Rabat., Elkhatib K. ,   Service de Chirurgie Plastique Reparatrice et des Brules de lHopital Militaire dInstruction Mohamed V-Rabat.
Published: January 2025

Le carcinome adenosquameux cutane, considere comme un sous-type agressif de carcinome epidermoide, est une tumeur maligne rare de la peau presentant des caracteristiques squameuses et glandulaires. Il se manifeste souvent par des papules ou plaques indurees, erythemateuses et keratosiques, localisees sur la tete ou le cou des patients ages ayant des antecedents de dommages actiniques. Lexposition solaire reste le facteur de risque majeur. La surveillance etroite est essentielle, car les recidives locoregionales sont frequentes, bien que les metastases adistance soient rares. Il sagit dun patient de 52 ans, seropositif pour le VIH sous traitement antiretroviral, qui consulte pour une tumeur frontale droite apparue depuis 18 mois. La tumeur mesurant 1,5 cm x 1 cm, ulcero-bourgeonnante et mobile. Une biopsie montre une proliferation tumorale malpighienne epitheliale. Un bilan dextension est prescrit, revelant labsence dextension osseuse et dadenopathies. La chirurgie est realisee avec une marge de 10 mm. Lanalyse histologique confirme le diagnostic de carcinome adenosquameux cutane avec infiltration perineurale, sans embole vasculaire. Les marges chirurgicales etaient saines, avec une marge profonde a 2 mm, necessitant une reprise avec reconstruction par lambeau en H, et une surveillance etroite est instauree. Apres 3 mois de surveillance, le patient est perdu de vue, et revient un an plus tard avec une masse jugale droite douloureuse, qui peut etre soit une nouvelle localisation, soit une metastase ganglionnaire. Un scanner revele une formation tissulaire parotidienne et des nodules pulmonaires. Une TEP au F-FDGconfirme une masse tumorale et des metastases. Une chimiotherapie est indiquee. Souligner linteret du ganglion sentinelle dans la prevention des metastases ganglionnaire. Le traitement optimal inclut la chirurgie de Mohs et la radiotherapie adjuvante pour les cas avances. Un diagnostic precoce et une prise en charge therapeutique adaptee sont cruciaux pour ameliorer le pronostic de cette tumeur agressive.
SOCIO-ENVIRONMENTAL IMPACTS OF THE TEXTILE CHAIN: CONSUMER KNOWLEDGE AND BEHAVIOR
Authors:   PhD in Environmental Sciences (UFSCar) Federal University of Sao Carlos (UFSCar)., Siebert Fernanda , Costa Goncalves Juliano ,   PhD in Environmental Engineering Sciences (USP), Professor, Federal University of Sao Carlos (UFSCar).
Published: January 2025

Although many media outlets are currently addressing the impact of the textile fashion chain, there is a way through which outlets consumers find out about it. In this context, a questionnaire of knowledge and consumer behavior about clothing products. The results show that more than 50% of the consumers answered off of many impacts related to the fashion chain no of the origin of the products they buy; However, they consider it important to obtain more knowledge to deal with the problem described, it is suggested that communication and environmental education policies be expanded.
Presentación volumen 12
Authors: Castrillón C. Andrés Alfredo
Published: January 2025

Perseitas ha perseverado en el tiempo como una revista que divulga el pensamiento, la investigación, la reflexión y los diversos estudios filosóficos, teológicos, humanísticos, así como las creaciones artísticas, en procura de presentar resultados valiosos para el amplio público orientándose a un diálogo abierto, franco y respetuoso.
Service innovation in telecommunication: The path to customer loyalty through enhanced customer satisfaction
Authors: Kumar Chaudhary Manoj , Mani Ghimire Dinesh , Dhungana Madan , Kumar Chaudhary Rajesh , Adhikari Madhav , Thapa Shubhechchha
Published: January 2025

This study focuses on the Nepalese telecom sector, where service innovation is crucial for increasing customer satisfaction and gaining loyalty. In the rapidly evolving technological landscape, telecom service providers must continuously improve their offerings and customer experiences to draw in new customers and maintain their competitiveness. Based on a sample of 245 telecom customers, this study investigates how innovative service offerings lead to higher satisfaction levels and, in turn, greater customer loyalty. This study uses structural equation modeling (SEM) and a quantitative research approach to examine the association between customer satisfaction, customer loyalty, and service innovation in Nepal’s telecom industry. The study confirmed that service innovation (β = 0.23, p ≤ 0.01) directly influences customer satisfaction and significantly (β = 0.32, p ≤ 0.01) enhances customer loyalty in the Nepalese telecom sector. However, the study finds a negligible indirect impact of service innovation (β = 0.12, UL = 0.292, LL = -0.003) on customer loyalty when customer satisfaction is considered a mediator, indicating that customer satisfaction does not fully influence this relationship in the Nepalese telecom sector, suggesting that other variables, such as price sensitivity, switching costs, and consistency in service quality may also affect the relationship between service innovation, customer satisfaction, and loyalty. The results of this study will help the Nepalese telecom sector reevaluate its service innovation attempts, guiding executives to update their programs by offering new, reliable, high-quality services at affordable prices while considering different aspects of service innovation for strategic planning to attract loyal customers.
The interplay between knowledge management and organizational performance measurement through the mediating effect of innovation capability
Authors: A. Abou-Moghli Azzam
Published: January 2025

Knowledge management is a ‘know-how’ expression through which companies can access and apply their shared knowledge to achieve innovation, improve performance, and attain long-term competitive advantage. The present study investigates the association between knowledge management and organizational performance measurement with innovation capability mediating in the Jordanian Telecommunication sector. Descriptive and inferential statistics, such as regression analysis and structural equation modeling, were used to analyze 575 responses from employees working in major telecommunication companies like Zain, Orange, and Umniah. The performances of knowledge management impact on organizational performance measurement results were positive, with the R-square amounting to 0.803. The change of each predictor variable in terms of B was: Knowledge Creation, 0.179; Knowledge Storage, 0.196; Knowledge Sharing, 0.399; Knowledge Application, 0.221; and Knowledge Evaluation, 0.234. Further, Innovation capability positively mediates the impact of knowledge management on organizational performance measurement. Overall, the study’s findings emphasize that an enterprise should effectively handle its intellectual assets and enhance its innovation capabilities since it may have the potential to hold a competitive advantage and overall performance in an advanced era.
Acknowledgment The author is grateful to Middle East University, Amman, Jordan, for the financial support to cover this article’s publishing fee.
Urban waterlogging simulation of derived short-duration double-peak rainstorm pattern
Authors: Zhang Jinping , Kong Lingli , Li Xuechun
Published: January 2025

It is actually difficult to quantify the characteristics of short-duration double-peak rainstorm (SDDPR), so the current study on the urban waterlogging simulation of its rainstorm pattern is rare. In this study, a new derivation methodology of SDDPR considering rainfall statistics correlations is proposed. With the non-source inundation method with the geographic information system (GIS)-based storm water management model (SWMM), urban waterlogging is simulated to present the hydrological and hydrodynamic characteristics. The results show that the proposed new derivation methodology of SDDPR reflects the actual rainstorm well, and the simulated urban waterlogging situation of the derived rainstorm confirms the different characteristics of surface ponding at junctions, flow in conduits, and outflows in outlets: with the increase of conditional probability and recurrence period (RP), the situation with average ponding hour-duration and earlier ponding time has increased, which represents more retention water can be produced quickly. With the change of RP from 1 to 10 years, the rate of overloaded conduit numbers with its full-flow time being beyond 0.5 h to total conduit numbers has added from 48 to 78%, waterlogging area of the study area has increased from 105,400 to 2,080,000 m2, ponding depth attains to 50 cm gradually, and the southeast in the study area is prone to be waterlogged.
Advanced Pain Management in Patients with Terminal Cancer
Authors: Khojayeva Kamilla , Aubakirova Mina , Viderman Dmitriy
Published: January 2025

Understanding and managing pain in patients with terminal cancer is a vital
aspect of palliative care, aimed at relieving suffering and improving quality of life in the
final stages of illness. Studies indicate that approximately 50% of patients with stage 4
cancer report moderate to severe pain, with a quarter experiencing severe cancer-related
pain. Despite opioid prescriptions in 97% of cases, a significant portion of patients continues
to suffer unresolved pain during the last week of life. Cancer-related pain is multifaceted,
often involving nociceptive, neuropathic, and mixed elements, necessitating a
thorough, multidimensional approach to both assessment and treatment. The challenge
of opioid tolerance and the potential for addiction demands careful monitoring. Interventional
therapies, including nerve blocks and spinal cord stimulation, are gaining attention
as valuable complements or alternatives to opioid use. Additionally, alternative
methods like yoga, special diets, and food supplements provide diverse options for managing
pain. Psychological therapies, including cognitive-behavioral techniques and mindfulness,
address the mental and emotional dimensions of pain. Emerging technologies,
including artificial intelligence, hold promise for optimizing pain management in terminal
cancer care. This review explores advanced pain management strategies, focusing on
traditional opioid therapies, modern pharmaceutical innovations, and non-pharmacological
approaches such as alternative medicine, massage, dietary interventions, and psychological
therapy.
Role of Glycolysis and Nitric Oxide Pathway Crosstalk in Macrophages in Atherosclerosis
Authors: Kotlyarov Stanislav
Published: January 2025

Atherosclerosis is a complex multifactorial process that occurs in the vascular
wall over many years and is responsible for a number of major diseases that affect quality
of life and prognosis. A growing body of evidence supports the notion that immune
mechanisms underlie atherogenesis. Macrophages are considered one of the key participants
in atherogenesis, but their role in this process is multifaceted, which is largely due
to the peculiarities of their cellular metabolism. Glycolysis is not only an important
metabolic pathway in macrophages, but is also associated with their immune functions.
Glycolysis in macrophages has complex regulatory pathways and is cross-linked with nitric
oxide, which together determine the immune function of these cells. Thus, the immune
and metabolic links underlying atherogenesis are of research and clinical interest
in terms of their potential therapeutic opportunities.
Untargeted Metabolomics and Bioactivities Assessment of Xylaria ellisii, an Endophytic Fungus Isolated from the Leaf of the Plant Acorus calamus Linn.
Authors: Prajapati Chandrabhan , Rai Sachchida Nand , Singh Anurag Kumar , Rajak Naina , Garg Neha , Singh Santosh Kumar
Published: January 2025

Introduction:

Fungal endophytes have mutualistic associations with the plant's host, communicating
through genetic and metabolic processes. As a result, they gain the ability to generate therapeutically
effective metabolites and their derivatives.

Methods:

The current study aims to assess antioxidant potential along with the identification of robust metabolites
within the crude extract of a potent endophytic fungus Xylaria ellisii isolated from leaf tissues of the
Acorus calamus Linn plant.Four endophytic fungi were obtained from leaf tissues of Acorus calamus Linn.,
and identified morphologically and molecularly as distinct species. Each ethyl acetate extract of the isolated
fungi exhibited a unique chemical profile in the HPTLC fingerprint at various wavelengths. The ethyl acetate
(EA) extract from the fungal strain ACL-4 (Xylaria ellisii) demonstrated the strongest antioxidant activity
among the four fungal endophytes examined, with an EC50 value of 292.64 ± 3.558 μg/mL. Remarkably, fungal
endophyte ACL-4 extract exhibited superior antimicrobial activity at the less concentrations compared to
ACL-ME extract of leaf crude.

Results:

The extract of ACL-ME-treated HEK 293T cells exhibited significant toxicity, with an IC50 value of
1481.74 ± 23.772 μg/mL, compared to fungal strain ACL-4-treated HEK 293T cells, which had an IC50 value
greater than 2000 μg/mL. Consequently, the crude extract of ACL-4 and ACL-ME along with the standard
drug methotrexate exhibited cytotoxic activity against cancer cell line MDA-MB-231 with IC50 concentrations
of 146.65 ± 0.394 μg/mL, 528.46 ± 10.912 μg/mL, and 134.11 ± 3.446 μg/mL, respectively. A total of 2,255
compounds were detected through LC-HRMS-based metabolomics in the crude metabolites of Xylaria ellisii,
with certain compounds identified in multiple instances. Among this repertoire, 62 robust bioactive compounds
were identified through meticulous screening, guided by existing literature. Comparative HPTLC fingerprint
analysis, along with antioxidant efficacy assays of ethyl acetate extracts of Xylaria ellisii derived
from Acorus calamus leaves and Cassia fistula twigs revealed the host-specific production of bioactive chemicals.

Conclusion:

The top-scoring Keap1 inhibitors derived from Xylaria ellisii, including Pregabalin (-6.083
Kcal/mol), Ferulic acid (-5.434 Kcal/mol), (R)-Piperidine-2-carboxylic acid (-5.31 Kcal/mol), Genipin (-5.197
Kcal/mol), and Brivaracetam (-5.17 Kcal/mol), respectively were considered as Keap 1 inhibitors, potentially
mitigate oxidative stress.
Interesting Metformin-Based Derivatives with Versatile Pharmacology
Authors: Sahu Rakesh , Shah Kamal
Published: January 2025

Metformin is a popular biguanide medicine because of its efficacy and inexpensive cost. Over time,
other applications of metformin were found, and the advantages of metformin for diverse conditions such as
anticancer, anti-inflammatory, anticoagulant, antimicrobial, and many more were studied. Although the underlying
mechanism of these numerous benefits remains unknown, repurposing it is a smart concept, as it offers several
advantages, including reduced development and research costs. However, taking it as-is may result in unwanted
pharmacokinetics and mild to severe adverse effects. To overcome these, several researchers experimented
and reported modified metformin derivatives that had better pharmacological potential, favorable pharmacokinetics,
and fewer side effects. This review, therefore, sheds light on the current therapeutic expansion of
non-metal derivatives of metformin along with their synthesis methods and evaluated outcomes. This will support
researchers studying these modified or replaced metformins in the scientific community.
Neurological Insights into 16p11.2- And 22q11.2-Related Disorders: A
Mini-Review
Authors: Lu Yung-Hsiu , Chen Yann-Jang , Lin Shan-Ju , Hsu Ting-Rong , Niu Dau-Ming , Lin Wei-Sheng
Published: January 2025

Copy Number Variations (CNVs) involving 16p11.2 or 22q11.2 are often linked to neurodevelopmental and neuropsychiatric disorders, including autism spectrum disorder, attention deficit hyperactivity disorder, cognitive impairment, epilepsy, and schizophrenia. The pathogenetic
mechanisms underlying these neurological phenotypes remain incompletely understood, partly
due to the multitude of genes involved and the complex gene-gene interactions at these loci.
Nonetheless, recent advances in experimental technology and bioinformatics have greatly enhanced our understanding of the neurobiology of 16p11.2- and 22q11.2-related disorders. Herein,
we aim to provide an updated mini-review on neurological aspects of these disease-associated CNVs, with emphasis on clinical and mechanistic insights as well as potential therapeutic implications.
Recent Advances in Nanotherapeutics and Theranostics for Squamous Cell Carcinoma: A Comprehensive Review
Authors: Sharma Neeraj , KUMAR ABHIRAM , Sambhakar Sharda , Bhatia Daksh , Hussain Sahil , Mursal Mohd , Singh Bishambar , Narayan Kumar Pranav
Published: January 2025

Recent advancements in nanotherapeutics have revolutionized cancer treatment through
the integration of diagnostic and therapeutic modalities, known as theranostics. This critical review
examines the current landscape of nanotherapeutics for various cancers, such as bladder and head and
neck squamous cell carcinoma, highlighting current advancements in nanotherapeutics and challenges.
Key approaches discussed include biomimetic smart nanocarriers, polymeric smart nanocarriers,
inorganic-based smart nanocarriers, and nanorobots. Furthermore, diverse nanomaterials have been
explored in theranostics, including liposomes, polymeric nanoparticles, and inorganic nanoparticles
such as quantum dots and mesoporous silica nanoparticles. Furthermore, the integration of imaging
techniques such as surface-enhanced Raman scattering (SERS) and positron emission tomography
(PET) with therapeutic nanoparticles has been analyzed for potential clinical applications.
In Silico Pharmacogenomic Assessment of Glucagon-like Peptide-1 (GLP1) Agonists and the Genetic Addiction Risk Score (GARS) Related Pathways: Implications for Suicide Ideation and Substance Use Disorder
Authors: Sharafshah Alireza , Lewandrowski Kai-Uwe , Gold Mark S. , Fuehrlein Brian , Ashford J. Wes , Thanos Panayotis K. , Wang Gene Jack , Hanna Colin , Cadet Jean Lud , Gardner Eliot L. , Khalsa Jag H. , Braverman Eric R. , Baron David , Elman Igor , Dennen Catherine A. , Bowirrat Abdalla , Pinhasov Albert , Modestino Edward J. , Carney Paul R. , Cortese Rene , Fiorelli Rossano Kepler Alvim , Schmidt Sergio , Pollack Aryeh R. , Badgaiyan Rajendra D. , Blum Kenneth
Published: January 2025

Introduction:

Glucagon-Like Peptide-1 Receptor (GLP1R) agonists have become widespread
anti-obesity/diabetes pharmaceuticals in the United States.

Aim:

This article aimed to provide our current knowledge on the plausible mechanisms linked to the
role of Ozempic (Semaglutide), which is generalized as one of the anti-addiction compounds.

Methods:

The effects of GLP1R agonists in Alcohol Use Disorder (AUD) and substance use disorder
(SUD) are mediated, in part, through the downregulation of dopamine signaling. We posit that while
GLP1R agonism could offer therapeutic advantages in hyperdopaminergia, it may be detrimental in
patients with hypodopaminergia, potentially leading to long-term induction of Suicidal Ideation (SI).
The alleged posit of GLP1 agonists to induce dopamine homeostasis is incorrect. This study refined
31 genes based on the targets of Ozempic, GLP1R, and related enzymes for SI and 10 genes of the
Genetic Addiction Risk Score (GARS) test. STRING-MODEL refined 29 genes, and further primary
analyses indicated associations of GLP1R with DRD3, BDNF, CREB1, CRH, IL6, and DPP4.

Results:

In-depth silico enrichment analysis revealed an association between candidate genes and
depressive phenotypes linked with dopaminergic signaling. Finally, through primary and in-depth
silico analyses, we demonstrated multiple findings supporting that GLP1R agonists can induce depression
phenotypes.

Conclusion:

Our findings suggest that associated polymorphisms seem to have overlapping effects
with addictive behaviors of Reward Deficiency Syndrome (RDS) and dopamine regulation. Consequently,
GLP1R agonists may represent a double-edged sword, potentially triggering both antiaddictive
effects and SI by exacerbating depressive phenotypes. Thus, we encourage the scientific
community to perform further empirical clinical studies to confirm this proposed pathway.
Stable Gastric Pentadecapeptide BPC 157 as a Therapy of Severe Electrolyte Disturbances in Rats
Authors: Grubisic Marija Medvidovic , Strbe Sanja , Barisic Ivan , Balenovic Dijana , Stambolija Vasilije , Lozic Marin , Ostojic Sanja Barsic , Oreskovic Ivana , Zizek Helena , Brcic Klara , Coric Luka , Staresinic Mario , Blagaic Vladimir , Oreskovic Lidija Beketic , Halle Zeljka Belosic , Matek Danijel , Soldo Dragan , Grizelj Boris , Blagaic Alenka Boban , Skrtic Anita , Sikiric Predrag , Seiwerth Sven
Published: January 2025

This review explores the therapeutic potential of the stable gastric pentadecapeptide BPC
157 in addressing electrolyte imbalances, specifically hyperkalemia, hypokalemia, hypermagnesemia,
and hyperlithemia. In hyperkalemia, BPC 157 demonstrated a comprehensive counteractive effect
against KCl overdose (intraperitoneally, intragastrically, and in vitro), effectively mitigating
symptoms such as muscular weakness, hypertension, sphincter dysfunction, arrhythmias, and lethality.
It also counteracted the adverse effects of succinylcholine and magnesium overdose, including
systemic muscle paralysis, arrhythmias, and hyperkalemia. In hypokalemia, BPC 157 (administered
prophylactically or therapeutically, intraperitoneally or intragastrically) prevented fatal outcomes
and addressed furosemide-induced hypokalemia, ECG changes, AV conduction block, ventricular
arrhythmias, and skeletal muscle myoclonus. Following magnesium overdose, BPC 157 alleviated
muscle weakness, brain lesions, and hyperkalemia-induced complications. In vitro studies (HEK293
cells) revealed the ability of BPC 157 to counteract hyperkalemia- and hypermagnesemia-induced
depolarization and hypokalemia-induced hyperpolarization. In lithium intoxication, BPC 157 promoted
collateral pathway activation, resolved vascular and multiorgan failure, and counteracted advanced
Virchow triad conditions and occlusion-like syndromes. Collectively, these findings underscore
the therapeutic promise of BPC 157 in managing electrolyte imbalances and warrant further
investigation.
Developing the Learning Curve Model to Enhance Construction Project Scheduling and Cost Estimating
Authors: Salman Alaa , Sodangi Mahmoud
Published: January 2025

Aim

The aim of the study is to develop a scheduling and cost estimation model for repetitive construction units by applying the learning curve theory and to contribute to advancements in construction project management practices, promoting efficiency and competitiveness within the industry.

Background

Construction projects, particularly those with repetitive units like housing developments, face ongoing challenges in accurate scheduling and cost estimation. Traditional estimation methods often overlook the impact of learning effects, which can improve productivity and reduce costs as crews gain experience. Learning curve theory, widely applied in manufacturing, offers a framework to model these gains in construction settings. Integrating learning curves into project planning has the potential to enhance accuracy in forecasting timelines and budgets, ultimately improving project efficiency and resource management.

Objective

The objective of this study is to develop and apply a learning curve model to enhance scheduling and cost estimation in repetitive construction projects, particularly in a multi-unit housing project.

Methods

By incorporating historical data and analyzing critical factors that impact project duration and cost, a more reliable forecasting model is developed. The learning curves are created using a three-point approach, supported by artificial neural networks (ANN) and the relative importance index (RII), to systematically assess cost divisions and influential project factors.

Results

The results indicate that the learning curve model can achieve time savings of 27% and labor cost savings of 36% compared to traditional estimation methods that do not consider the effect of the learning curve in construction projects.

Conclusion

This research demonstrates that learning curve models, combined with advanced data analysis techniques, provide a robust framework for optimizing project schedules and budgets, ultimately leading to more efficient resource utilization and cost-effective project outcomes. In other words, the study presented in this paper is significant as it can lead to improved project outcomes, cost savings, better resource management, and overall advancement in the construction industry's practices and competitiveness. This approach allows for accurate scheduling and cost forecasting based on data-driven insights.