bluuebunny/crossref_metadata_2025 huggingface dataset:
Safety of Continuing Anticoagulation Prior to Cardiac Catheterization in Pediatric Patients: A Los Angeles Center Experience
Authors: Rao Mounica Y. , Sullivan Patrick M. , Takao Cheryl , Badran Sarah , Patel Neil D.
Published: February 2023

This is the first report specifically describing outcomes of pediatric patients who underwent cardiac catheterization while on uninterrupted anticoagulation. One hundred forty-four cardiac catheterizations were identified that met inclusion criteria at our institution from 11/2014 to 10/2019. The median age and weight of the patients were 6.3 [0.01–20.9] years and 19.3 [2.1–172.5] kg, respectively. Seventy-eight (54%) catheterizations involved inpatients. The most common cardiac diagnoses among the cohort were single ventricle (n = 41), conotruncal defects (n = 37), and structurally normal heart (n = 16). The most common indications for anticoagulation were arterial/venous thrombus (n = 45), Fontan physiology (n = 32), and mechanical valve thrombus prophylaxis (n = 27). The anticoagulation medications used were warfarin (n = 57), heparin (n = 52), enoxaparin (n = 25), fondaparinux (n = 5), rivaroxaban (n = 2), and both heparin and warfarin (n = 3). Interventions were performed in 96 cases (67%). The median length of the procedure was 122.5 [15–760] minutes, and the median time to achieve hemostasis was 18.0 [range: 5–76, IQR: 13–25] minutes. Adverse events were present in 11 cases (7.6%), and of those only 2 cases (1.4%) were bleeding-related complications. Our single-center data suggest that performing cardiac catheterization on pediatric patients while on uninterrupted anticoagulation is safe and does not substantially increase the risk of bleeding complications based on a cohort of patients that varied in age, size, diagnosis, medical complexity, and type of intervention performed. Patients on warfarin therapy for a mechanical valve are most likely to benefit from this practice, as the ability to continue warfarin therapy avoids the need for bridging and other interruption-related complications.
Energy content of krill and amphipods in the Barents Sea from summer to winter: variation across species and size
Authors: Nowicki Robynne C. , Borgå Katrine , Gabrielsen Geir Wing , Varpe Øystein
Published: February 2023

Arctic zooplankton develop large energy reserves, as an adaptation to strong seasonality, making them valuable prey items. We quantified the energy content (kJ g−1 dry weight) of abundant krill (arcto-boreal, Thysanoessa inermis and boreal, Meganyctiphanes norvegica) and amphipods (Arctic, Themisto libellula and sub-Arctic-boreal, Themisto abyssorum) in the Barents Sea in late summer (August) and early winter (December). Variation in energy content was attributed to species-specific traits and body size categories, the latter in part as a proxy for ontogeny. T. inermis had the highest energy content, (Aug: 26.8 ± 1.5 (SD) kJ g−1) and remained similar from summer to winter. Energy content increased in M. norvegica and decreased in both amphipod species, with the lowest energy content being in T. abyssorum (Dec: 17.8 ± 0.8 kJ g−1). The effect of body size varied between species, with energy content increasing with size in T. inermis and T. libellula, and no change with size in M. norvegica and T. abyssorum. The reproductive stages of T. libellula differed in energy content, being highest in gravid females. Energy content varied with species’ dependence on energy storage. Our findings highlight how phylogenetically and morphologically similar prey items cannot necessarily be considered equal from a predator´s perspective. Energetically, the northern T. inermis was higher quality compared to the more southern M. norvegica, and mostly so during summer. Ecological models and management strategies should consider such variation in prey quality, especially as Arctic borealization is expected to change species composition and the energetic landscape for predators.
Radiation dose optimization for photon-counting CT coronary artery calcium scoring for different patient sizes: a dynamic phantom study
Authors: Dobrolinska Magdalena M. , van der Werf Niels R. , van der Bie Judith , de Groen Joël , Dijkshoorn Marcel , Booij Ronald , Budde Ricardo P. J. , Greuter Marcel J. W. , van Straten Marcel
Published: February 2023

Purpose

To systematically assess the radiation dose reduction potential of coronary artery calcium (CAC) assessments with photon-counting computed tomography (PCCT) by changing the tube potential for different patient sizes with a dynamic phantom.

Methods

A hollow artery, containing three calcifications of different densities, was translated at velocities corresponding to 0, < 60, 60–75, and > 75 beats per minute within an anthropomorphic phantom. Extension rings were used to simulate average- and large -sized patients. PCCT scans were made with the reference clinical protocol (tube potential of 120 kilovolt (kV)), and with 70, 90, Sn100, Sn140, and 140 kV at identical image quality levels. All acquisitions were reconstructed at a virtual monoenergetic energy level of 70 keV. For each calcification, Agatston scores and contrast-to-noise ratios (CNR) were determined, and compared to the reference with Wilcoxon signed-rank tests, with p < 0.05 indicating significant differences.

Results

A decrease in radiation dose (22%) was achieved at Sn100 kV for the average-sized phantom. For the large phantom, Sn100 and Sn140 kV resulted in a decrease in radiation doses of 19% and 3%, respectively. Irrespective of CAC density, Sn100 and 140 kVp did not result in significantly different CNR. Only at Sn100 kV were there no significant differences in Agatston scores for all CAC densities, heart rates, and phantom sizes.

Conclusion

PCCT at tube voltage of 100 kV with added tin filtration and reconstructed at 70 keV enables a ≥ 19% dose reduction compared to 120 kV, independent of phantom size, CAC density, and heart rate.

Key Points

• Photon-counting CT allows for reduced radiation dose acquisitions (up to 19%) for coronary calcium assessment by reducing tube voltage while reconstructing at a normal monoE level of 70 keV.

• Tube voltage reduction is possible for medium and large patient sizes, without affecting the Agatston score outcome.
Localization and tracking of stationary users for augmented reality
Authors: Baker Lewis , Ventura Jonathan , Langlotz Tobias , Gul Shazia , Mills Steven , Zollmann Stefanie
Published: February 2023

In augmented reality applications it is essential to know the position and orientation of the user to correctly register virtual 3D content in the user’s field of view. For this purpose, visual tracking through simultaneous localization and mapping (SLAM) is often used. However, when applied to the commonly occurring situation where the users are mostly stationary, many methods presented in previous research have two key limitations. First, SLAM techniques alone do not address the problem of global localization with respect to prior models of the environment. Global localization is essential in many applications where multiple users are expected to track within a shared space, such as spectators at a sporting event. Secondly, these methods often assume significant translational movement to accurately reconstruct and track from a local model of the environment, causing challenges for many stationary applications. In this paper, we extend recent research on Spherical Localization and Tracking to support relocalization after tracking failure, as well as global localization in large shared environments, and optimize the method for operation on mobile hardware. We also evaluate various state-of-the-art localization approaches, the robustness of our visual tracking method, and demonstrate the effectiveness of our system in real-life scenarios.
Feasibility and preliminary effectiveness of a psychosocial support program for adolescent and young adult cancer patients in clinical practice: a retrospective observational study
Authors: Hirayama Takatoshi , Fujimori Maiko , Ito Yoshinori , Ishida Yuji , Tsumura Akemi , Ozawa Miwa , Maeda Naoko , Yamamoto Kazuhito , Takita Sakie , Mori Makiko , Tanaka Kyoko , Horibe Keizo , Akechi Tatsuo
Published: February 2023

Purpose

Adolescent and young adult cancer patients (AYAs) often experience profound psychological distress, with various unmet supportive care needs that can be alleviated with appropriate screening and attention by healthcare workers. The Distress Thermometer and Problem List-Japanese version (DTPL-J) is our previously developed screening tool to facilitate individual support of AYAs. This study evaluated the feasibility and preliminary effectiveness of a psychosocial support program based on the DTPL-J for AYAs in clinical practice.

Methods

This multicenter, retrospective, observational study included 19 of 126 wards and 9 of 75 outpatient clinics at 8 institutions in Japan. Over 200 patients were expected to participate during the eligibility period. Patients participated in a support program at least once, and approximately once a month based on the DTPL-J results. The program was evaluated using the RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) implementation framework.

Results

The screening rate of the 361 participants was 90.3%, suggesting high feasibility. Distress Thermometer scores, the number of supportive care needs, and the rates of AYAs with high distress were significantly reduced 1 month after screening (p < 0.05), suggesting the preliminary effectiveness of the program. The program was continued at the 8 institutions as part of routine care after the study.

Conclusion

Analysis using the RE-AIM suggested the sufficient feasibility and preliminary effectiveness of a psychosocial support program based on the DTPL-J for AYAs.

Trial registration

University Hospital Medical Information Network (UMIN CTR) UMIN000042857. Registered 25 December 2020—Retrospectively registered.
Constant rank theorems for curvature problems via a viscosity approach
Authors: Bryan Paul , Ivaki Mohammad N. , Scheuer Julian
Published: February 2023

An important set of theorems in geometric analysis consists of constant rank theorems for a wide variety of curvature problems. In this paper, for geometric curvature problems in compact and non-compact settings, we provide new proofs which are both elementary and short. Moreover, we employ our method to obtain constant rank theorems for homogeneous and non-homogeneous curvature equations in new geometric settings. One of the essential ingredients for our method is a generalization of a differential inequality in a viscosity sense satisfied by the smallest eigenvalue of a linear map Brendle et al. (Acta Math 219:1–16, 2017) to the one for the subtrace. The viscosity approach provides a concise way to work around the well known technical hurdle that eigenvalues are only Lipschitz in general. This paves the way for a simple induction argument.
Compensatory mechanisms from different exercise intensities in type 2 diabetes: a secondary analysis of a 1-year randomized controlled trial
Authors: Correia Inês R. , Hetherington-Rauth Megan , Magalhães João P. , Júdice Pedro B. , Rosa Gil B. , Henriques-Neto Duarte , Manas Asier , Ara Ignacio , Silva Analiza M. , Sardinha Luís B.
Published: February 2023

Aims

This investigation aimed to determine the effect of different intensities of training on non-exercise physical activity (NEPA) and estimated thermogenesis (NEAT) from a 1-year exercise randomized controlled trial (RCT) in individuals with type 2 diabetes mellitus (T2DM) on non-training days. Additionally, changes in NEPA and estimated NEAT in those who failed (low-responders) or succeeded (high-responders) in attaining exercise-derived clinically meaningful reductions in body weight (BW) and fat mass (FM) (i.e., 6% for FM and 3% for BW) was assessed.

Methods

Individuals with T2DM (n = 80) were enrolled in a RCT with three groups: resistance training combined with moderate-intensity continuous training (MICT) or high-intensity interval training (HIIT) and a control group. Of the 80 participants, 56 (completed data) were considered for this secondary analysis. NEPA and estimated NEAT were obtained by accelerometry and body composition through dual-energy X-ray absorptiometry.

Results

After adjustments, no time*group interactions were found for estimated NEAT in the MICT (β = − 5.33, p = 0.366) and HIIT (β = − 5.70, p = 0.283), as well as for NEPA in the MICT (β = − 452.83, p = 0.833) and HIIT (β = − 2770.76, p = 0.201), when compared to controls. No compensatory changes in NEPA and estimated NEAT were observed when considering both low-responders and high-responders to FM and BW when compared to controls.

Conclusions

Both MICT and HIIT did not result in any compensatory changes in estimated NEAT and NEPA with the intervention on non-training days. Moreover, no changes in estimated NEAT and NEPA were found when categorizing our participants as low-responders and high-responders to FM and BW when compared to controls.

Trial registration clinicaltrials.gov ID.

NCT03144505.
Sensor integrating plain bearings: design of an energy-autonomous, temperature-based condition monitoring system
Authors: Baszenski Thao , Kauth Kevin , Kratz Karl-Heinz , Gutiérrez Guzmán Francisco , Jacobs Georg , Gemmeke Tobias
Published: February 2023

Plain bearings are increasingly being used under mixed friction, resulting in a higher risk of wear-induced failure. Therefore, the relevance of condition monitoring is increasing, which can enable the early detection of wear inducing conditions. The presented work focuses on the development of an energy-autonomous, temperature-based condition monitoring system for plain bearings. The components of the condition monitoring system are to be integrated directly into the machine element and operating data to be transmitted wirelessly.

The fundamental monitoring approach pursued, is the in-operando calculation of the lubrication gap height via the standardized Gümbel-curve based on the temperature map in the plain bearing. If the gap height undercuts a critical threshold, the plain bearing will operate in mixed friction. Thus, representing a potentially wear-causing operating point. The energy required for operating the system is harvested thermoelectrically within the plain bearing via thermo-generators, which use the temperature gradients in the plain bearing during operation.

In this work, the simulative evaluation of the harvestable energy will be presented. The usable temperature difference will be determined for varying positioning of the energy harvester. The results obtained allow the subsequent manufacture of a first Sensor integrating Machine Element (SiME)-prototype. In this context a feasible setup regarding the types and number of sensors as well as a microcontroller for processing the measured data will be defined with respect to the harvestable energy. Furthermore, the principle for temperature-based gap height determination will be introduced, applied for different operating points and compared to simulative results.
The Western origins of mindfulness therapy in ancient Rome
Authors: Cavanna Andrea E. , Purpura Giulia , Riva Anna , Nacinovich Renata , Seri Stefano
Published: February 2023

Stoic philosophy has multiple parallels with cognitive behavioural therapy interventions. In their ancient texts, the Roman Stoics present a set of theoretical principles and behavioural strategies that are directly relevant to the clinical care of patients with a wide range of neuropsychiatric conditions. Mindfulness is a key component of the ‘third wave’ of modern psychotherapy that closely resembles the ancient Stoic practice of attention or ‘concentration on the present moment’. Stoic mindfulness draws attention to one of the main principles driving both Stoicism and modern psychotherapy: the assumption that cognitive activity (reasoning) mediates emotions and behaviours. This principle can be traced back to Epictetus’ Enchiridion, where he recognises that ‘men are disturbed not by things, but by the views which they take of things’. It has been shown that cognitive behavioural therapies and mindfulness-based interventions directed at patients with neuropsychiatric disorders were originally developed as Stoic-inspired treatment interventions. Both Albert Ellis and Aaron Beck (the founders of rational emotive behaviour therapy and cognitive behavioural therapy, respectively) explicitly acknowledged the role of Stoicism as the philosophical precursor of their treatment approaches. The effective implementation of evidence-based guidelines would benefit from an increased awareness of the influence of the Stoic tradition of philosophical therapy on the treatment approaches currently in use in neuropsychiatry.
Left-truncated health insurance claims data: theoretical review and empirical application
Authors: Weißbach Rafael , Dörre Achim , Wied Dominik , Doblhammer Gabriele , Fink Anne
Published: February 2023

From the inventory of the health insurer AOK in 2004, we draw a sample of a quarter million people and follow each person’s health claims continuously until 2013. Our aim is to estimate the effect of a stroke on the dementia onset probability for Germans born in the first half of the 20th century. People deceased before 2004 are randomly left-truncated, and especially their number is unknown. Filtrations, modelling the missing data, enable circumventing the unknown number of truncated persons by using a conditional likelihood. Dementia onset after 2013 is a fixed right-censoring event. For each observed health history, Jacod’s formula yields its conditional likelihood contribution. Asymptotic normality of the estimated intensities is derived, related to a sample size definition including the number of truncated people. The standard error results from the asymptotic normality and is easily computable, despite the unknown sample size. The claims data reveal that after a stroke, with time measured in years, the intensity of dementia onset increases from 0.02 to 0.07. Using the independence of the two estimated intensities, a 95% confidence interval for their difference is [0.053, 0.057]. The effect halves when we extend the analysis to an age-inhomogeneous model, but does not change further when we additionally adjust for multi-morbidity.
Suprapontine Structures Modulate Brainstem and Spinal Networks
Authors: Mohammadshirazi Atiyeh , Apicella Rosamaria , Zylberberg Benjamín A. , Mazzone Graciela L. , Taccola Giuliano
Published: February 2023

Several spinal motor output and essential rhythmic behaviors are controlled by supraspinal structures, although their contribution to neuronal networks for respiration and locomotion at birth still requires better characterization. As preparations of isolated brainstem and spinal networks only focus on local circuitry, we introduced the in vitro central nervous system (CNS) from neonatal rodents to simultaneously record a stable respiratory rhythm from both cervical and lumbar ventral roots (VRs).

Electrical pulses supplied to multiple sites of brainstem evoked distinct VR responses with staggered onset in the rostro-caudal direction. Stimulation of ventrolateral medulla (VLM) resulted in higher events from homolateral VRs. Stimulating a lumbar dorsal root (DR) elicited responses even from cervical VRs, albeit small and delayed, confirming functional ascending pathways. Oximetric assessments detected optimal oxygen levels on brainstem and cortical surfaces, and histological analysis of internal brain structures indicated preserved neuron viability without astrogliosis. Serial ablations showed precollicular decerebration reducing respiratory burst duration and frequency and diminishing the area of lumbar DR and VR potentials elicited by DR stimulation, while pontobulbar transection increased the frequency and duration of respiratory bursts. Keeping legs attached allows for expressing a respiratory rhythm during hindlimb stimulation. Trains of pulses evoked episodes of fictive locomotion (FL) when delivered to VLM or to a DR, the latter with a slightly better FL than in isolated cords.

In summary, suprapontine centers regulate spontaneous respiratory rhythms, as well as electrically evoked reflexes and spinal network activity. The current approach contributes to clarifying modulatory brain influences on the brainstem and spinal microcircuits during development.

Graphical Abstract

Novel preparation of the entire isolated CNS from newborn rats unveils suprapontine modulation on brainstem and spinal networks. Preparation views (A) with and without legs attached (B). Successful fictive respiration occurs with fast dissection from P0-P2 rats (C). Decerebration speeds up respiratory rhythm (D) and reduces spinal reflexes derived from both ventral and dorsal lumbar roots (E).
How Cultural Transmission Through Objects Impacts Inferences About Cultural Evolution
Authors: Crema Enrico R. , Bortolini Eugenio , Lake Mark
Published: February 2023

The cross-fertilisation between biological and cultural evolution has led to an extensive borrowing of key concepts, theories, and statistical methods for studying temporal variation in the frequency of cultural variants. Archaeologists have been among the front-runners of those engaging with this endeavour, and the last 2 decades have seen a number of case studies where modes of social learning were inferred from the changing frequencies of artefacts. Here, we employ a simulation model to review and examine under-discussed assumptions shared by many of these applications on the nature of what constitutes the ‘population’ under study. We specifically ask (1) whether cultural transmission via ‘objects’ (i.e. public manifestations of cultural traits) generates distinct patterns from those expected from direct transmission between individuals and (2) whether basing inference on the frequency of objects rather than on the frequency of mental representations underlying the production of those objects may lead to biased interpretations. Our results show that the rate at which ideational cultural traits are embedded in objects, and shared as such, has a measurable impact on how we infer cultural transmission processes when analysing frequency-based archaeological data. At the same time, when cultural transmission is entirely mediated by the material representation of ideas, we argue that copying error should be interpreted as a two-step process which may occur in either one or both of embedding information in objects and retrieving it from them.
Characterizing Schwarz maps by tracial inequalities
Authors: Carlen Eric , Müller-Hermes Alexander
Published: February 2023

Let$$\phi $$ϕbe a positive map from the$$n\times n$$n×nmatrices$$\mathcal {M}_n$$Mnto the$$m\times m$$m×mmatrices$$\mathcal {M}_m$$Mm. It is known that$$\phi $$ϕis 2-positive if and only if for all$$K\in \mathcal {M}_n$$K∈Mnand all strictly positive$$X\in \mathcal {M}_n$$X∈Mn,$$\phi (K^*X^{-1}K) \geqslant \phi (K)^*\phi (X)^{-1}\phi (K)$$ϕ(K∗X-1K)⩾ϕ(K)∗ϕ(X)-1ϕ(K). This inequality is not generally true if$$\phi $$ϕis merely a Schwarz map. We show that the corresponding tracial inequality$${{\,\textrm{Tr}\,}}[\phi (K^*X^{-1}K)] \geqslant {{\,\textrm{Tr}\,}}[\phi (K)^*\phi (X)^{-1}\phi (K)]$$Tr[ϕ(K∗X-1K)]⩾Tr[ϕ(K)∗ϕ(X)-1ϕ(K)]holds for a wider class of positive maps that is specified here. We also comment on the connections of this inequality with various monotonicity statements that have found wide use in mathematical physics, and apply it, and a close relative, to obtain some new, definitive results.
Explosive Events in the Quiet Sun Near and Beyond the Solar Limb Observed with the Interface Region Imaging Spectrograph (IRIS)
Authors: Alissandrakis C. E. , Vial J.-C.
Published: February 2023

We study point-like explosive events (EE), characterized by emission in the far wings of spectral lines, in a quiet region near the South Pole, using Interface Region Imaging Spectrograph (IRIS) spectra at two slit positions, slit-jaw (SJ) observations, and Atmospheric Imaging Assembly (AIA) images. The events were best visible in Si iv spectra; they were weak in SJs, occasionally visible in 1600 Å and 304 Å AIA images, and invisible in higher temperature AIA images. We identified EEs from position–time images in the far wings of the Si iv lines and measured their distance from the limb. A Gaussian model of the height distribution showed that EEs occur in a narrow (0.9′′) height range, centered at 3.2′′ above the continuum limb at 2832.0 Å. On the disk, we found that they occur in network boundaries. Further, we studied the line profiles of two bright EEs above the limb and one on the disk. We found that what appears as broad-band emission is actually a superposition of 2 – 3 narrow-band Gaussian components with well-separated line profiles, indicating that material is expelled towards and/or away from the observer in discrete episodes in time and in space. The expelled plasma accelerates quickly, reaching line-of-sight (LOS) velocities up to 90 km s−1. Overall, the motion was practically along the LOS, as the velocity on the plane of the sky was small. In some cases, tilted spectra were observed that could be interpreted in terms of rotating motions of up to 30 km s−1. We did not find any strong absorption features in the wing of the Si iv lines, although in one case, a very weak absorption feature was detected. No motions indicative of jets were detected in SJ or AIA images. Reconnection in an asymmetric magnetic-field geometry, in the middle or near the top of small loops, is a plausible explanation of their observational characteristics.
Audiologists’ perceived value of ototoxicity management and barriers to implementation for at-risk cancer patients in VA: the OtoMIC survey
Authors: Konrad-Martin Dawn , Polaski Rachel , DeBacker J. Riley , Theodoroff Sarah M. , Garinis Angela , Lacey Cecilia , Johansson Kirsten , Mannino Rosemarie , Milnes Trisha , Hungerford Michelle , Clark Khaya D.
Published: February 2023

Purpose

Platinum-based chemotherapies used to treat many types of cancers are ototoxic. Ototoxicity management (OtoM) to mitigate the ototoxic outcomes of cancer survivors is recommended practice yet it is not a standard part of oncologic care. Although more than 10,000 patients each year are treated with platinum-based chemotherapies at the US Veterans Health Administration (VA), the current state of OtoM in VA is not well-defined. This study reports on a national survey of VA audiologists’ perceptions regarding OtoM in cancer patients.

Methods

A 26-item online survey was administered to VA audiologists and service chiefs across the VA’s 18 regional systems of care. Descriptive statistics and deductive thematic analysis were used to analyze the data.

Results

The 61 respondents included at least one from each VA region. All reported they felt some form of OtoM was necessary for at-risk cancer patients. A pre-treatment baseline, the ability to detect ototoxicity early, and management of ototoxic effects both during and after treatment were considered high value objectives of OtoM by respondents. Roughly half reported routinely providing these services for patients receiving cisplatin and carboplatin. Respondents disagreed regarding appropriate hearing testing schedules and how to co-manage OtoM responsibilities with oncology. They identified barriers to care that conformed to three themes: care and referral coordination with oncology, audiology workload, and lack of protocols.

Conclusions

Although VA audiologists value providing OtoM for cancer patients, only about half perform OtoM for highly ototoxic treatment regimens. The OtoMIC survey provides clinician perspectives to benchmark and address OtoM care gaps.

Implications for cancer survivors

Collaboration between oncology and audiology is needed to improve current OtoM processes, so that cancer survivors can have more control over their long term hearing health.
Socially Assistive Devices in Healthcare–a Systematic Review of Empirical Evidence from an Ethical Perspective
Authors: Haltaufderheide Joschka , Lucht Annika , Strünck Christoph , Vollmann Jochen
Published: February 2023

Socially assistive devices such as care robots or companions have been advocated as a promising tool in elderly care in Western healthcare systems. Ethical debates indicate various challenges. An important part of the ethical evaluation is to understand how users interact with these devices and how interaction influences users’ perceptions and their ability to express themselves. In this review, we report and critically appraise findings of non-comparative empirical studies with regard to these effects from an ethical perspective.

Electronic databases and other sources were queried using a comprehensive search strategy generating 9851 records. Studies were screened independently by two authors. Methodological quality of studies was assessed. For 22 reports on 21 datasets using a non-comparative design a narrative synthesis was performed.

Data shows positive findings in regard to attitudes and emotional reactions of users. Varying perception of a social relation and social presence are the most commonly observed traits of interaction. Users struggle with understanding technical complexities while functionality of the devices is limited. This leads to a behavioral alignment of users towards the requirements of the devices to be able to make use of them.

This evidence adds to three important ethical debates on the use of socially assistive devices in healthcare in regard to (1) reliability of existing empirical evidence to inform normative judgements, (2) ethical significance of the social presence of devices and (3) user autonomy in regard to behavioral alignment.
How Neurotech Start-Ups Envision Ethical Futures: Demarcation, Deferral, Delegation
Authors: Knopf Sophia , Frahm Nina , M. Pfotenhauer Sebastian
Published: February 2023

Like many ethics debates surrounding emerging technologies, neuroethics is increasingly concerned with the private sector. Here, entrepreneurial visions and claims of how neurotechnology innovation will revolutionize society—from brain-computer-interfaces to neural enhancement and cognitive phenotyping—are confronted with public and policy concerns about the risks and ethical challenges related to such innovations. But while neuroethics frameworks have a longer track record in public sector research such as the U.S. BRAIN Initiative, much less is known about how businesses—and especially start-ups—address ethics in tech development. In this paper, we investigate how actors in the field frame and enact ethics as part of their innovative R&D processes and business models. Drawing on an empirical case study on direct-to-consumer (DTC) neurotechnology start-ups, we find that actors engage in careful boundary-work to anticipate and address public critique of their technologies, which allows them to delineate a manageable scope of their ethics integration. In particular, boundaries are drawn around four areas: the technology’s actual capability, purpose, safety and evidence-base. By drawing such lines of demarcation, we suggest that start-ups make their visions of ethical neurotechnology in society more acceptable, plausible and desirable, favoring their innovations while at the same time assigning discrete responsibilities for ethics. These visions establish a link from the present into the future, mobilizing the latter as promissory place where a technology’s benefits will materialize and to which certain ethical issues can be deferred. In turn, the present is constructed as a moment in which ethical engagement could be delegated to permissive regulatory standards and scientific authority. Our empirical tracing of the construction of ‘ethical realities’ in and by start-ups offers new inroads for ethics research and governance in tech industries beyond neurotechnology.
The Dual Therapeutic Potential of Ottelione A on Carbon Tetrachloride-induced Hepatic Toxicity in Mice
Authors: Zahran Rasha Fekry , EL-sayed Lina Mahmoud , Hoye Thomas Robert , Ayyad Seif-Eldin Nasr
Published: February 2023

Background

Some herbal natural products play an important role in protecting organisms from the toxic effect of some xenobiotics. The present study was designed to evaluate the potential therapeutic effects of Ottelione A (OTTE) against carbon tetrachloride(CCl4)-induced toxicity in mice.

Methods

Adult male Swiss albino mice were divided into six groups: group I was used as a normal control received olive oil; group II received DMSO; group III received OTTE; group IV received CCl4 in olive oil, (injected i.p) 3 times/week for 6 weeks; group V received the same CCl4 regimen as group IV followed by OTTE injected for 15 days, and group VI first received OTTE injected for 15 days followed by the same CCl4 regimen as group IV. Some biochemical and histological parameters were investigated.

Results

Our results showed that the administration of CCl4 caused hepatotoxicity, as monitored by the significant increase in biochemical parameters concerning the olive oil group. Treatment with OTTE appeare d to be effective against hepatotoxic and liver changes induced by CCl4, as evidenced by the improvement of the same parameters.

Conclusion

Ottelione A (OTTE) has good antioxidant and therapeutic properties, which can help in preventing CCl4-induced hepatotoxicity in both pre-treatment and post-treatment modes.

Graphical Abstract
$$SU(2)^2$$-Invariant Gauge Theory on Asymptotically Conical Calabi–Yau 3-Folds
Authors: Stein Jakob
Published: February 2023

We give a complete description of the behaviour of Calabi–Yau instantons and monopoles with an$$SU(2)^2$$SU(2)2-symmetry, on Calabi–Yau 3-folds with asymptotically conical geometry and$$SU(2)^2$$SU(2)2acting with co-homogeneity one. We consider gauge theory on the smoothing and small resolution of the conifold, and on the canonical bundle of$$\mathbb{C}\mathbb{P}^1 \times \mathbb{C}\mathbb{P}^1$$CP1×CP1, with their known asymptotically conical co-homogeneity one Calabi–Yau metrics, and find new one-parameter families of invariant instantons. We also entirely classify the relevant moduli-spaces of instantons and monopoles satisfying a natural curvature decay condition, and show that the expected bubbling phenomena occur in these families of instantons.
The Role of Cow’s Milk Consumption in Breast Cancer Initiation and Progression
Authors: Melnik Bodo C. , John Swen Malte , Carrera-Bastos Pedro , Cordain Loren , Leitzmann Claus , Weiskirchen Ralf , Schmitz Gerd
Published: February 2023

Purpose of Review

This review evaluates cow milk’s impact on breast carcinogenesis by linking recent epidemiological evidence and new insights into the molecular signaling of milk and its constituents in breast cancer (BCa) pathogenesis.

Recent Findings

Recent prospective cohort studies support the association between cow’s milk consumption and the risk of estrogen receptor-α-positive (ER+) BCa. Milk is a complex biological fluid that increases systemic insulin-like growth factor 1 (IGF-1), insulin and estrogen signaling, and interacting hormonal promoters of BCa. Further potential oncogenic components of commercial milk include exosomal microRNAs (miR-148a-3p, miR-21-5p), bovine meat and milk factors, aflatoxin M1, bisphenol A, pesticides, and micro- and nanoplastics. Individuals with BRCA1 loss-of-function mutations and FTO and IGF1 gain-of-function polymorphisms enhancing IGF-1/mTORC1 signaling may be at increased risk for milk-induced ER+ BCa.

Recent prospective epidemiological and pathobiochemical studies identify commercial milk consumption as a critical risk factor of ER+ BCa. Large meta-analyses gathering individuals of different ethnic origins with milk derived from dairy cows of varying genetic backgrounds and diverse feeding procedures as well as missing data on thermal processing of milk (pasteurization versus ultra-heat treatment) make multi-national meta-analyses unsuitable for BCa risk estimations in susceptible populations. Future studies are required that consider all vulnerable periods of breast carcinogenesis to cow’s milk exposure, beginning during the perinatal period and puberty, since these are the most critical periods of mammary gland morphogenesis. Notwithstanding the need for better studies including detailed information on milk processing and vulnerable periods of human breast carcinogenesis, the available evidence suggests that dietary guidelines on milk consumption may have to be reconsidered.
Increase in methicillin-susceptible Staphylococcus aureus bloodstream infections in Switzerland: a nationwide surveillance study (2008–2021)
Authors: Renggli Luzia , Gasser Michael , Buetti Niccolò , Kronenberg Andreas ,   the Swiss Centre for Antibiotic Resistance
Published: February 2023

Purpose

An increasing burden of Staphylococcus aureus bloodstream infections (BSI), despite a decrease in the percentage of methicillin-resistant S. aureus (MRSA), was described recently in other European countries. The main aim of this study was to analyse recent temporal trends of S. aureus, methicillin-susceptible S. aureus (MSSA) and MRSA BSI for Switzerland as well as the different linguistic regions within Switzerland. An additional aim was to estimate potential differences among patient-based and epidemiological risk factors.

Methods

A retrospective observational study was conducted in Switzerland over a period of 14 years (2008–2021). Trends in S. aureus, MSSA and MRSA BSI were analysed by applying linear regression models.

Results

Staphylococcus aureus BSI increased by + 30% from 19.7 to 25.6 cases per 100,000 inhabitants between 2008 and 2021 (P < 0.01) in Switzerland. Thereof, MSSA increased by + 37% from 17.8 to 24.4 cases per 100,000 inhabitants (P < 0.01). MRSA decreased from 1.9 to 1.2 cases per 100,000 inhabitants (P < 0.01), which was driven by decreasing incidence in the French-speaking region. MSSA BSI increased significantly (P < 0.01) in both linguistic regions. A further stratification revealed that incidence increased the most in male patients of the age group ≥ 80 years of the German-speaking region.

Conclusion

The increasing health burden of MSSA BSI in Switzerland indicates that not only proportions of resistant microorganisms but also total BSI incidences should be monitored. In addition, data stratification revealed that the increase was mainly driven by an increasing incidence in elderly males of the German-speaking region.
Residual stress stability of HFMI-treated transverse attachments under variable amplitude loading with the P(1/3) and the linear spectrum
Authors: Löschner Daniel , Diekhoff Paul , Schiller Richard , Engelhardt Imke , Nitschke-Pagel Thomas , Dilger Klaus
Published: February 2023

The potential of HFMI treatment to increase fatigue life under service loading remains in debate. However, some recent studies show that even under variable amplitude loading (VAL), fatigue strength is increased compared to untreated welds. Discussions generally focus on the stability of initial compressive residual stresses, which may be reduced during VAL due to high peak stresses. In this context, the potential of HFMI treatment is often only attributed to residual stress stability. This study presents further results on the effect of VAL with a P(1/3) and a linear load spectrum on the residual stress stability of HFMI-treated transverse stiffeners (TS) made of mild steel (S355) and high-strength steel (S700M). The impact of random, High-Low and Low-High loading sequences on the fatigue strength as well as on the residual stress behaviour of HFMI-treated joints will be discussed.
Classification for the Concrete Syntax of Graph-Like Modeling Languages
Authors: Wrobel Gregor , Scheffler Robert
Published: February 2023

A classification scheme for Graph-Like Modeling Languages (GLML) is presented in this paper. The novelty of this classifier lies in its application to a meta-model for GLML that deviates from the simple graph model and underlies a large number of GLML. The main goal of using this classification scheme is to support the reuse of layout algorithms for GLML. GLML are used directly or indirectly for the development of software by model-based software engineering techniques. In other domains, graph-like models are artifacts (e.g., circuit diagrams, energy flow diagrams) that serve as input for downstream specialized applications (simulators, optimizers). The concrete syntax of a language for creating, editing, and understanding models is highly important for the development of modeling tools. Layout methods for the used languages have to be implemented to achieve software tools with good usability. Developing layout algorithms is a complex topic that is covered by the specialized field of Graph Drawing. However, there is no existing procedure to determine which layout algorithm can be used for a GLML. Matching layout algorithms to GLML can be achieved by applying the presented classification scheme.
Modulation of allergic contact dermatitis via gut microbiota modified by diet, vitamins, probiotics, prebiotics, and antibiotics
Authors: Kiecka Aneta , Macura Barbara , Szczepanik Marian
Published: February 2023

Allergic contact dermatitis is one of the most common recorded occupational diseases. There are many different substances that the skin comes into contact with on a daily basis and that can cause ACD, e.g., preservatives, surfactants, and antimicrobial agents. The development of a mouse model of ACD has provided insight into the immune mechanisms involved. Drugs used in the treatment of skin diseases have many side effects. Therefore, alternative methods of suppressing the immune response to reduce the symptoms of skin diseases are being sought. In recent years, high hopes have been placed on dietary modulation and supplementation to affect the intestinal microbial composition and promote anti-inflammatory responses. In addition, other studies have shown the crucial role of intestinal microbiota in many immune-mediated diseases. Recognition and characterization of pro- and anti-inflammatory nutrients and supplements may be crucial to support the treatment of diseases such as atopic dermatitis, acne vulgaris, psoriasis, and allergic contact dermatitis.
Systematic literature review of the role of e-commerce in providing pathways to sustainability for poverty alleviation in Sub-Saharan Africa
Authors: Cordes Darrold L. , Marinova Dora
Published: February 2023

Poverty elimination by 2030 is the major initiative of the United Nations Sustainable Development Goals. However, poverty in Sub-Saharan Africa is rising. There is an absence of structural reform for transformational change across the region. E-commerce is an enabler of small and large businesses in developed economies. Community-led initiatives for poverty alleviation may benefit from the transactional capabilities of e-commerce for direct trade with suppliers and consumers. Well-structured small and medium-size enterprises (SMEs) can foster local innovation and entrepreneurship, and collaboration between SMEs can enhance product development and marketing strategies. This review aims to discover formal research into the application of e-commerce in sustainable development models for poverty alleviation in Sub-Saharan Africa, and the extent of innovation, entrepreneurship, and collaboration among SMEs. The review found an absence of formal research into theories and practical strategies for sustainability innovations across the low-income spectrum. Organizational structures have not been developed to stimulate outreach, to foster innovation and entrepreneurship, or to embrace technology. Further, there is limited discussion on the importance of collaboration for the sharing of knowledge and joint business activities, but there is acknowledgement that SMEs can provide spatially diversified sustainable development. This article proposes a framework for the implementation and management of networks of SMEs focused on the sustainable development of low-income communities.
High ultraviolet-B sensitivity due to lower CPD photolyase activity is needed for biotic stress response to the rice blast fungus, Magnaporthe oryzae
Authors: Mmbando Gideon S. , Ando Sugihiro , Takahashi Hideki , Hidema Jun
Published: February 2023

Sensitivity to ultraviolet-B (UVB, 280–315 nm) radiation varies widely among rice (Oryza sativa) cultivars due to differences in the activity of cyclobutane pyrimidines dimer (CPD) photolyase. Interestingly, cultivars with high UVB sensitivity and low CPD photolyase activity have been domesticated in tropical areas with high UVB radiation. Here, we investigated how differences in CPD photolyase activity affect plant resistance to the rice blast fungus, Magnaporthe oryzae, which is one of the other major stresses. We used Asian and African rice cultivars and transgenic lines with different CPD photolyase activities to evaluate the interaction effects of CPD photolyase activity on resistance to M. oryzae. In UVB-resistant rice plants overexpressing CPD photolyase, 12 h of low-dose UVB (0.4 W m−2) pretreatment enhanced sensitivity to M. oryzae. In contrast, UVB-sensitive rice (transgenic rice with antisense CPD photolyase, A-S; and rice cultivars with low CPD photolyase activity) showed resistance to M. oryzae. Several defense-related genes were upregulated in UVB-sensitive rice compared to UVB-resistant rice. UVB-pretreated A-S plants showed decreased multicellular infection and robust accumulation of reactive oxygen species. High UVB-induced CPD accumulation promoted defense responses and cross-protection mechanisms against rice blast disease. This may indicate a trade-off between high UVB sensitivity and biotic stress tolerance in tropical rice cultivars.

Graphical Abstract
Stable anisotropic minimal hypersurfaces in
Authors: Chodosh Otis , Li Chao
Published: February 2023

We show that a complete, two-sided, stable immersed anisotropic minimal hypersurface in$\mathbf {R}^4$has intrinsic cubic volume growth, provided the parametric elliptic integral is$C^2$-close to the area functional. We also obtain an interior volume upper bound for stable anisotropic minimal hypersurfaces in the unit ball. We can estimate the constants explicitly in all of our results. In particular, this paper gives an alternative proof of our recent stable Bernstein theorem for minimal hypersurfaces in$\mathbf {R}^4$. The new proof is more closely related to techniques from the study of strictly positive scalar curvature.