bluuebunny/crossref_metadata_2025 huggingface dataset:
El sistema de salud en Colombia 1945-2020: entre la realidad y el imaginario social
Authors: Morales Sánchez Luis Gonzalo
Published: January 2025

Este ensayo describe los principales hechos sociales, políticos y económicos del mundo entre 1919 y 1993 que enmarcaron el desarrollo de la protección social en salud en Colombia. Al Tratado de Versalles al final de la Primera Guerra Mundial en 1919, que creó la Organización Internacional del Trabajo, le siguieron la Gran Depresión mundial en 1929 y la Segunda Guerra Mundial en 1939. Luego, se inicia (1945) un período de crecimiento económico conocido como los Estados de Bienestar, que finaliza con la crisis mundial del petróleo en 1973, que se asocia al surgimiento del Neoliberalismo. China y la URSS también son analizados como formas de organización social no capitalista. En Colombia, la protección social en salud comienza con la creación del Ministerio de Salud y los Seguros Sociales (1945), continua con el Sistema Nacional de Salud (1976) y finaliza con el Sistema General de Seguridad Social en Salud (1993), que algunos califican de receta neoliberal y retroceso social, lo que sigue siendo motivo de debate.
Estado, salud y políticas públicas. Reflexiones sobre los agentes sanitarios en Posadas y Eldorado, Misiones-Argentina
Authors: Martínez Jorge Nicolás , Avalos Miguel Alejandro , Báez María Fernanda
Published: January 2025

Objetivo Analizar la política pública de la provincia de Misiones-Argentina en materia de atención primaria de la salud, específicamente el Programa de Promotores de Salud.
Metodología La metodología utilizada fue cualitativa, desde una orientación etnográfica. Integramos los datos obtenidos en las entrevistas y las observaciones de dos investigaciones realizadas en las localidades de Posadas (2013-2016) y Eldorado (2017-2018).
Resultados Los promotores son nexos entre la población y el sistema de salud, se ubican en las márgenes del sistema y trabajan en las márgenes de la sociedad. Tres elementos son característicos de su práctica: a) reproducen la mirada biomédica; b) ofician de traductores entre el saber letrado y la población; y c) posibilitan y promueven ciertas acciones transaccionales de los sujetos.
Conclusiones Los promotores, en cuanto “nexos”, ocupan una posición estratégica y privilegiada que podría ser potenciada de manera más efectiva en la implementación de políticas públicas en el territorio, particularmente en lo que hace a prácticas de prevención y promoción de la salud.
Reflexiones sobre lineamientos formativos en Trabajo Social en la Corporación Universitaria Rafael Núñez
Authors: Zambrano Vanegas Rafael Alberto , Gonzalez Navarro Rocio Margarita
Published: January 2025

El artículo presenta las reflexiones sobre la formación en Trabajo Social realizadas por docentes, estudiantes y egresados del programa de Trabajo Social de la Corporación Universitaria Rafael Núñez, campus Cartagena y Barranquilla, a la luz del proceso desarrollado por la Comisión de Actualización de Criterios de Formación en Trabajo Social del Consejo Nacional para la Educación en Trabajo Social (Conets) y en el marco de la construcción participativa local, regional y nacional de lineamientos para la formación profesional, desarrollada entre 2020 a 2022. Se presentan para ello los antecedentes históricos y gremiales del Conets, los referentes conceptuales y las tendencias en Latinoamérica que sustentan la pluralidad en la formación profesional, el proceso de elaboración de lineamientos curriculares para la formación en Trabajo Social en Colombia y la metodología desarrollada en la Corporación Universitaria Rafael Núñez. Además, se abordan los aportes referidos al proceso de formación a partir del planteamiento de tres preguntas orientadoras de acuerdo con los temas centrales apropiados en la formación profesional, su pertinencia en relación con el contexto actual, la profesión y la formación en Trabajo Social, además de otras temáticas conexas.
Expropriações contemporâneas: reflexões sobre a situação trágica do povo Yanomami no Brasil
Authors: Claudino Guimarães Karoline , Martins Pinheiro Silvia Silva
Published: January 2025

Este artigo tem como objetivo principal analisar criticamente, a partir de uma perspectiva marxista, os processos expropriatórios contemporâneos, considerado como uma de suas expressões mais nítidas e brutais na atualidade a situação dos povos Yanomami. Tal cenário envolve não apenas a dinâmica capitalista no contexto de crise, mas também o acirramento da política neoliberal no Brasil, a qual, nos últimos anos tem refletido no aumento e na aceleração das expropriações. Esse aprofundamento tem impactado direta e indiretamente as condições de vida e de subsistência não apenas da classe trabalhadora, mas, ainda,  dos povos originários, que seguem padecendo, sobretudo, devido ao avanço dos garimpos ilegais em territórios indígenas, da falta de políticas públicas e da degradação e destruição do meio ambiente.
Cambios socioambientales en un ecosistema de páramo seco en el nororiente de Colombia
Authors: Amorocho Pérez Amanda Patricia , Aceros Gualdrón Juan Carlos , Serrano Acevedo Nathalia
Published: January 2025

Los páramos son ecosistemas que se han convertido en zonas de intervención agrícola. Esta situación los ha vuelto vulnerables al deterioro medioambiental. Sin embargo, las investigaciones sobre la presencia del ser humano en los páramos colombianos son escasas. Este trabajo buscó conocer la vida social en el páramo de Berlín y su interacción con el entorno natural, a través de un diagnóstico participativo. Este proceso propició la implicación de la población en la reflexión sobre los cambios socioambientales. Los resultados muestran la crisis a la que se enfrentan los pobladores ante las transformaciones socioeconómicas de su territorio.
Del bienestar individual a los cuidados colectivos. Experiencias asociativas de las mujeres (in)migradas en España
Authors: Cuadra Durán Cristina , Agrela Romero Belén
Published: January 2025

Este artículo está enmarcado en una investigación sobre cuidados comunitarios articulados por mujeres (in)migradas (2020-2024) y estudia los vínculos de interdependencia que construyen en España las mujeres procedentes de Latinoamérica mediante la participación en agrupaciones y asociaciones comunitarias autogestionadas. A partir de las reflexiones y prácticas que tejen en torno a la colectivización de sus autocuidados, analizamos las estrategias para asegurar la reproducción de sus vidas e incidir en los actuales debates y desafíos sobre organización social de los cuidados en el sur de Europa.
Negociación sociotécnica
Authors: Calvo Dafne , Cabrera Altieri Daniel H.
Published: January 2025

En este artículo exploramos teóricamente la interacción entre comunidades sociotécnicas y tecnología desde las prácticas de la negociación. La negociación se presenta como un proceso complejo que implica conflictos y acuerdos dentro de los movimientos sociales. Mediante un análisis cualitativo de las comunidades sociotécnicas en España, comprobamos que sus usos, discursos y valores en torno a la tecnología implican cuestiones individuales, colectivas y oposicionales. Concluimos que la existencia de la negociación en las comunidades está íntimamente ligada a la asimetría de la apropiación tecnológica, que implica una revisión constante de los límites de sus prácticas asociadas. Al mismo tiempo, la negociación ofrece a las comunidades una mayor flexibilidad y adaptabilidad al contexto en el que opera su acción colectiva.
A dinâmica dos campos discursivos de ação de um movimento social feminista no enfretamento da violência obstétrica no Amazonas
Authors: Brito Rayana Gonçalves de , Miguez Sâmia Feitosa , Neves André Luiz Machado das
Published: January 2025

A ação política e discursiva dos movimentos sociais no combate à violência obstétrica está sendo desenhado em todo o país. Tomou-se como unidade de análise o contexto de atuação de um movimento feminista do estado, a Humaniza Coletivo Feminista. Realizou-se pesquisa de campo com abordagem qualitativa de dados, que combinou técnicas, como entrevistas, levantamento documental, observação direta e caderneta de campo. A pesquisa foi ancorada na noção de campos discursivos de ação, de Sônia Alvarez, e revelou que na judicialização dos casos de violência obstétrica, novas pautas e estratégias reconfiguram o repertório de atuação dos movimentos sociais para se fazer justiça e elaboram nova gramática política, baseada no diálogo e parceria com o estado e poder político, visando o compromisso com o combate à violência obstétrica no Amazonas.
La catalogación de los conocimientos tradicionales
Authors: Vargas-Chaves Iván
Published: January 2025

La falta de protección adecuada de los conocimientos tradicionales facilita su apropiación indebida por terceros, sin el consentimiento de las comunidades poseedoras. En este contexto, la catalogación o elaboración de inventarios de conocimientos tradicionales y expresiones culturales surge como una alternativa para fortalecer los mecanismos de protección de estos saberes ancestrales. Este artículo analiza las ventajas y desafíos de la catalogación de este conocimiento, con el objetivo de establecer un marco conceptual y unas reflexiones que aporten en los debates y futuras aproximaciones sobre este tema. A partir de una revisión sistemática de literatura especializada, y desde un enfoque de metodología de análisis documental, desde este estudio se identifican aspectos a favor y los riesgos potenciales de este proceso de catalogación. Como aportes, se formulan a modo de propuesta unos principios y criterios mínimos para una catalogación ética, que incluyen el respeto a la propiedad intelectual, la participación de los poseedores tradicionales mediante una consulta previa y la confidencialidad sobre la información y conocimientos recopilados. Por último, se concluye que es necesario considerar otras dimensiones socioculturales, como la equidad en la distribución de beneficios, la protección de la identidad cultural y el diálogo intercultural.
Autoconceito e representações sociais de brasileiros acerca de suas vivências LGBTQIA+
Authors: De Sousa Barros Neto Raimundo Nonato , Fernandes de Araújo Ludgleydson , Cardoso Ferreira Alda Vanessa
Published: January 2025

Objetivo. A pesquisa teve por objetivo identificar os elementos constituintes do autoconceito e a estrutura representacional de brasileiros acerca de suas vivências LGBTQIA+. Método. O estudo contou com a participação de 120 pessoas LGBTQIA+, com idade entre 18 e 42 anos (M = 27.19 e DT = 5.95). Para a coleta de dados, utilizou-se um questionário sociodemográfico e o Teste de Associação Livre de Palavras (TALP), com o estímulo indutor “Eu mesmo”. Resultados. A análise indicou que os participantes apresentaram representações positivas de si mesmos, sugerindo um autoconceito saudável. Entretanto, apesar dos traços positivos predominantes, os estressores enfrentados por pessoas LGBTQIA+ podem afetar negativamente o autoconceito. Nesse sentido, algumas das palavras evocadas após a apresentação do estímulo indutor se referem a características e sentimentos negativos, associados a um autoconceito empobrecido.
GENERALIDADES. PRINCIPIOS DE DERECHO PRIVADO y DEL DERECHO REAL EN GENERAL.
Authors: Rojas Herrera Óscar Miguel
Published: January 2025

La siguiente investigación realiza un análisis de los elementos y componentes más relevantes de los Derechos Reales. Esto con el fin de realizar una compilación de conceptos, características, teorías, tesis entre otros aspectos de los cursos de Derechos Reales I y Derechos Reales II, con el objetivo de facilitar el estudio de las personas interesadas en el tema. Además, el siguiente cuadernillo realiza un análisis de Derecho Comparado con países de Argentina y España, para brindar una visión más amplia de algunos temas con la legislación nacional.
Participación de las mujeres en la pesca artesanal en el norte del Perú en el contexto del cambio climático
Authors: Alarcón Guadalupe , Tam Jorge , Zavala José
Published: January 2025

En Perú, la participación de la mujer en la pesca artesanal ha sido invisibilizada y poco estudiada, en especial porque su participación en el proceso de extracción pesquera está restringida en muchas comunidades artesanales. Por tal motivo, el objetivo del presente estudio es caracterizar la participación de las mujeres involucradas en la pesca artesanal en las caletas de El Ñuro y Los Órganos del norte del Perú, bajo el contexto del cambio climático. A través de métodos participativos, se analizaron los capitales y medios de vida de las mujeres, su participación en la cadena productiva de la pesca artesanal, y elco-diseño de acciones afirmativas para su adaptación al cambio climático. Se encontró que las mujeres participan en procesos pesqueros como: preparación, manipuleo, venta primaria, transporte y venta final; sin embargo, para futuros proyectos de pesca artesanal con enfoque de género son necesarias acciones afirmativas como el procesamiento convalor agregado, la producción de biofertilizantes, el ecoturismo, la acuicultura sostenible,la gastronomía y las artesanías marinas.
La nominalización del “científico” y “científica” durante la Revolución Científica
Authors: Laris Pardo Jorge Alejandro
Published: January 2025

En la historiografía de la ciencia actual, que está fuertemente influenciada por corrientes anglosajonas, se ha vuelto obligatorio señalar que William Whewell (1794-1866) acuñó en 1834 la palabra “scientist” en inglés, debido a la dificultad de encontrar una voz equivalente al alemán “natur-forscher”. El propósito de este documento es cuestionar si es correcto aplicar esta reflexión para la evolución de la palabra “científico” o “científica”. Con ello en mente, se sustenta el estudio de la nominalización de esta palabra en el español. Se estudian fuentes históricas con el auxilio de herramientas digitales como el Corpus del  Diccionario histórico de la lengua española (CDH), el Corpus Diacrónico del español (CORDE) y el Nuevo Tesoro Lexicográfico de la Lengua Española (NTLLE) de la Real Academia de la Lengua Española; el Diccionario de la Ciencia y de la Técnica del Renacimiento de la Universidad de Salamanca; así como la base de datos de Google Ngram. Estas búsquedas se han complementado con testimonios que el autor ha recabado a lo largo de sus investigaciones y un diálogo con la historiografía pertinente. Se concluye que la evolución de nuestra palabra “científica” o “científica” no corresponde a la anglosajona. Por el contrario, su origen se encuentra en un largo proceso de nominalización.
Complejidad en el concepto de comunidad en estudios académicos en ciencias sociales: reflexiones y desafíos
Authors: Uribe Lopera Lucas , González Montero Sebastian Alejandro , Vinaccia Alpi Stefano , Montoya Tomás
Published: January 2025

El concepto de comunidad es ampliamente utilizado en las ciencias sociales, perosu uso polisémico y general puede limitar la comprensión de realidades socialescomplejas. Este artículo presenta una reflexión sobre el concepto de comunidad a partirde un análisis sistemático de su uso en la literatura académica de 2022. Se priorizaron2430 artículos académicos y se analizaron 7 categorías conceptuales donde seevidencia una diversidad de enfoques y perspectivas, pero también una falta de claridadconceptual y una falta de atención a la simetría de los actores humanos y no humanosen la construcción de comunidades.
LA PERICIA ODONTOLÓGICA FORENSE EN EL PROCESO PENAL COSTARRICENSE: A PROPÓSITO DE LA VALORACIÓN PROBATORIA SOBRE EL ANÁLISIS COMPARATIVO DE HUELLAS DE MORDEDURA
Authors: Jiménez Solano Francisco
Published: January 2025

Este artículo tiene como objetivo analizar algunos aspectos generales del análisis comparativo de huellas de mordedura, dentro del universo de pericias practicadas por la odontología forense. Dicho análisis comparativo ha sido objeto de fuertes críticas por la literatura académica en los Estados Unidos, donde se ha cuestionado la metodología utilizada, la fiabilidad de sus resultados y las premisas de las cuales se parte para darle una suerte de sustento científico. La discusión ha adquirido especial relevancia a partir de la exoneración de personas condenadas penalmente con fundamento en comparaciones de huellas de mordeduras con impresiones dentales, una vez prueba científica de mayor entidad (como el ADN) ha permitido corroborar su inocencia. En Costa Rica, no es una probanza ampliamente utilizada, y no se cuenta con ejemplos en la jurisprudencia que permitan examinar el razonamiento probatorio al valorarla. Sin embargo, el Organismo de Investigación Judicial cuenta con una Unidad de Odontología Forense y dicho análisis comparativo dentro de las pericias que pueden practicarse. De allí que sea relevante apreciar las objeciones que se le han planteado en otras latitudes, para procurar una correcta valoración y el uso adecuado de los mecanismos procesales puestos a disposición de los profesionales en Derecho que deban cuestionarla.
¡EL “FETO” ES NIÑO! ANÁLISIS DEL SUJETO PASIVO DEL DELITO DE ABORTO.
Authors: Funes Orellana Jorge
Published: January 2025

Partiendo del concepto jurídico de “persona” y “niño” introducido por las normas internacionales de derechos humanos, se demuestra que el “feto” es persona y niño.
Prediction of SOC content using NIR spectroscopy and DSANN
Authors: Jakkan Digambar Aggayya , Ghare Pradnya , Kumar Nirmal , Sakode Chandrashekhar
Published: January 2025

Soil organic carbon (SOC) levels directly affect the production and health of crops. Making use of a database of the usefulness of using the 350–2,500 nm Near Infra Red (NIR) spectroscopy data range on 200 soil samples from the Indian state of Uttar Pradesh was evaluated in this study. The more sophisticated Artificial Neural Network, to choose the spectral components that were used to forecast SOC, Random Forest (RF) and Ensemble Lasso-Ridge Regression (ELRR) were utilized. In the preprocessing, the inversion derivative, logarithmic(log) derivative, and logarithmic base to 10(log10x) derivatives were employed to duplicate the spectrum wavelength. The main characteristic of spectrum wavelength for SOC were found to be within the range of 350 and 450 nm, per the results. The best accurate estimation of SOC content was obtained by combining the suggested DSANN or Dropout Sequential ANN technique with the Log10x pre-processed data. The R-squared (R2), RMSE, and RPIQ (Ratio of Performance in Inter Quartile Distance) values for the testing dataset were 0.83, 0.08, and 4.32, respectively.
Investigating the mechanical performance of innovative bean pod ash particulates reinforced in AA6063 alloy for construction and building applications
Authors: Ben Festus , Olubambi Peter Apata
Published: January 2025

The AA6063, renowned for its corrosion resistance, faces limitations in construction and building applications due to its low mechanical strength. Bean pod ash (BPAp), a byproduct of the agro-waste heat-treatment process, presents an innovative and sustainable alternative to synthetic reinforcements. This study aims to improve the mechanical properties of AA6063 by incorporating BPAp and a hybrid of BPAp and alumina. Four aluminum matrix composites (AMCs), including unreinforced AA6063, were fabricated using a two-step stir-casting process with 10 wt.% BPAp and alumina in varying weight ratios. The microstructure, porosity, hardness, tensile strength, Young’s modulus, and ductility of the AMCs were evaluated. SEM analysis showed uniform BPAp dispersion and porosity below 4%, indicating lightweight AMCs. The composites exhibited enhanced mechanical properties, showing increased hardness (74.70-to-105.04 BHN), tensile strength (118.87-to-207.49 MPa), ductility (5.00-to-12.22%), and Young’s modulus (13.25-to-15.63 GPa). These findings demonstrate that BPAp effectively enhances AA6063 and offers a cost-effective, eco-friendly reinforcement solution.

Graphical abstract
Integration of modern technologies into the usual teaching process using biological markers as a predictor of disease development and progression
Authors: Ostanko V. L.
Published: January 2025

The article summarizes the experience of modern teaching methods at the Department of Hospital Internal Medicine with a course of rehabilitation, physiotherapy and sports medicine of the Siberian State Medical University. The methods of art and multitherapy, flipped classroom, ways of using biomarkers in practice, including a gastropanel, diagnostic indices and scales as prognostic values for the course and outcome of diseases are considered. The methods of teacher-simulated patient and bedside teaching with an "unknown" patient are considered, as well as the potential of problem-based classes and integrative lectures. The potential of distance teaching technologies is expanded.
Model for Strengthening Teachers' Innovative Work Behavior in Facing the Challenges of the Society 5.0 Era in Indonesia
Authors: Sherly . , Efendi . , Sihombing Humiras Betty Marlina , Romy Elly , Sudirman Acai
Published: January 2025

This research aimed to analyze model for strengthening innovative work behavior of North Sumatra teachers in facing the challenges of Society 5.0 era. Quantitative and SEM methods were adopted with Partial Least Squares Modeling (PLS-SEM) through transformational leadership, creative self-efficacy, proactive personality, and organizational support. In this context, new opportunities were obtained for a deeper understanding of the complex relationships between key variables influencing innovative work behavior model of teachers. Additionally, the research sample comprised 200 teachers in North Sumatra Province, Indonesia. The data analysis used the SEM method with PLS-SEM. The results showed that transformational leadership, creative self-efficacy, proactive personality, and organizational support had a positive and significant effect on innovative work behavior. Concerning the implications, innovative work behavior of teachers served as a critical factor in ensuring the quality of education was adaptive and relevant to the demands of Society 5.0 era. Policymakers could use the result to design more effective training and development programs, focusing on transformational leadership, strengthening creative self-efficacy, and providing better organizational support.
Перечень нормативно-правовых актов, определяющих подготовку врачей-лечебников, врачей-терапевтов и врачей общей практики (семейных врачей) 2024г.
Authors: Шепель Р. Н. , Астанина С.  Ю. , Закроева А.  Г. , Викторова И. A. , Ховаева Я. Б. , Друк И. В. , Тетенева А. В. , Бакиров Б. А. , Самойлов Т. В.
Published: January 2025

В соответствии с планом работы Координационного совета преподавателей кафедр терапевтических дисциплин образовательных организаций Российской Федерации.
GIS-based drought assessment for water-sensitive urban planning in Anantapur district
Authors: Dharmavarapu Aparna Sai , Navya Dasari N.V.S. , Shravya Achanala , Sarfraj Shaik
Published: January 2025

GIS technological assessment of drought conditions is essential for water-sensitive development, especially in areas like Anantapur District in Andhra Pradesh. This semi-arid region faces severe water scarcity, worsened by weather patterns and farming methods. GIS offers a comprehensive method for assessing, visualising, and managing drought vulnerabilities, enabling targeted interventions. By evaluating the spatial distribution of drought vulnerability, GIS techniques facilitate the creation of spatial maps that highlight climate and environmental factors. The Weighted Overlay Tool of GIS generates a drought vulnerability index, incorporating variables like vegetation, soil moisture, and precipitation levels to provide a detailed understanding of drought effects. GIS modelling also identifies suitable sites for groundwater recharge by integrating successful water management practices. This study aims to enhance inter-district assistance and self-sustainability by mapping interventions to ensure efficient resource use. The results offer valuable insights to policymakers and urban planners, promoting sustainable development in Anantapur. Additionally, the approach provides a replicable model for other water-scarce regions, aiding decision-makers in resource allocation and infrastructure development to mitigate drought impacts.
Interplay between Skeletal Muscle Catabolism and Remodeling of Arteriovenous Fistula via YAP1 Signaling
Authors: Wu Yongdong , Lee Tae Hoon , Cheng Owen H. , Peden Eric , Li Qingtian , Wang Jun , Huang Fengzhang , Melancon Marites P. , Sheikh-Hamad David , Wang Tao , Truong Luan , Mitch William , Liang Ming , Cheng Jizhong
Published: January 2025

Background:

Arteriovenous (AV) fistulas are the preferred access for dialysis but have a high incidence of failure. This study aims to understand the crosstalk between skeletal muscle catabolism and AV fistula maturation failure.

Methods:

Skeletal muscle metabolism and AV fistula maturation were evaluated in mice with chronic kidney disease (CKD). The roles of myostatin and YAP1 in regulating the transdifferentiation of adventitial mesenchymal stem cells (mesenchymal stem cells) and intima hyperplasia in AV fistula were investigated. Nanoparticles carrying a YAP1 inhibitor, verteporfin, with light irradiation-controlled release were synthesized and applied to AV fistula.

Results:

Increased trichrome signals and stenosis were observed in AV fistulas from mice treated with myostatin and from mice with CKD. In contrast, blocking myostatin function with an anti-myostatin peptibody not only improved body weight and muscle size in CKD mice but also decreased neointima formation in AV fistulas. In cultured mesenchymal stem cells, myostatin induced YAP1 expression, promoting the differentiation of mesenchymal stem cells into myofibroblasts and inducing extracellular matrix deposition. Red light irradiation-controlled release of verteporfin from nanoparticles blocked YAP1 activation and alleviated myostatin-induced mesenchymal stem cell activation. Periadventitial application and red-light irradiation of nanoparticles carrying verteporfin significantly suppressed stiffening and neointima formation in AV fistula.

Conclusions:

CKD induced muscle wasting leading to increased production of myostatin, which stimulated mesenchymal stem cell activation and vascular fibrosis linked to AV fistula stenosis. YAP1 signaling was activated in these processes. Red-light irradiation-controlled release of verteporfin offered a feasible approach for local vascular drug intervention to improve AV fistula maturation.
Ascertaining the Effectiveness of Coordination Training Interventions in Enhancing Sports Performance: A Systematic Review and Meta-analysis
Authors: Saini Ashwani , Dubey Bipin Kumar , Vishwakarma Rakesh
Published: January 2025

Objectives. The study aimed to analyze the effects of training programs that focused on various coordination exercises to improve the sports performance and coordination of athletes.
Materials and methods. An electronic review was conducted to compile the literature related to this issue, using Scopus, PubMed, Google Scholar and ProQuest databases. Following a systematic search, eleven studies carried out between 2014 to 2024 were considered appropriate for meta-analysis and were retrieved and analysed. The studies included were confined to different coordination interventions, such as balance, rhythm, agility, neuromuscular training, jump ropeladder exercises, spatial orientation, non-sports specific and proprioceptive training, ranging from 6 weeks to an annual macrocycle with participants (sub-junior and junior levels) from different sports.
Results. The meta-analysis revealed a small effect size improvement for balance training (E = 0.38; 95 % CI = -0.66-2.54; p = 0.25), a large effect size and significant enhancement for coordination and rhythm training (E = 2.2; 95 % CI= -0.98-1.45; p = 0.70). Additionally, it was noted a moderate effect size and substantial improvement for a specific coordinative ability training (E = 1.8; 95 % CI = -0.84-2.99; p = 0.00) when compared the experimental group with the control group. The results of 11 studies established a significant effect size of various coordination training interventions in improving motor coordination of athletes. However, the impact of these interventions on sports skills and performance remains limited and inadequate.
Conclusions. After a thorough analysis, it was concluded that various training regimens involving different stimuli, means and methods, comprising proprioceptive training, spatial training, motor rhythm training, neuromuscular training, balance training, coordination training drills using ladders, wobble board, bosu balls, trampoline and dynamic games, as well as non-specific sports training with basic exercises, have been found to be effective in enhancing motor coordination and sports skills.
CLASSIFIERS OF TECHNOLOGICAL POLICY INSTRUMENTS AND THEIR REFLECTION IN COUNTRY EXPERIENCES
Authors:   National Research University Higher School of Economics, Shashkov Artem , Malekova Dina ,   National Research University Higher School of Economics, Veselitskaya Natalia ,   National Research University Higher School of Economics
Published: January 2025

Modern technological policy plays a crucial role in stimulating economic growth and enhancing national competitiveness. However, the absence of a unified and systematic classification of technological policy instruments hinders a comprehensive and targeted approach to their utilization. It is hypothesized that existing classifiers do not fully capture the real experiences and potential applications of these instruments. This study conducts a critical analysis of current classifications based on the experiences of leading technological powers, including Russia, China, the United States, Japan and Republic of Korea. An additional foundation for examining classification elements is the indicative approach, which plays a significant role in implementing technological policy within theoretical frameworks of public administration, such as New Public Management and New Public Governance. The analysis reveals several shortcomings of existing classifications, including excessive simplification, a multiplicity of classification criteria, insufficient detail on the instruments, and a lack of universality, which collectively impede a thorough understanding of diverse technological policy approaches. Consequently, this research aims to develop a new universal classification of technological policy instruments that reflects their targeted nature, considers international experience, and exhibits a higher level of universality and systematicity. The development of this classification aims to improve the effectiveness of technological policy instrument application in achieving strategic development goals while creating a more transparent and comprehensible system for analyzing and evaluating the effectiveness of technological policies.
Optimized CTAB DNA extraction for different tissues v1
Authors: Godinez-Vidal Damaris , C Groen Simon
Published: January 2025

CTAB (cetyltrimethylammonium bromide) DNA extraction is a method for isolating genomic DNA from different tissues. This method employs a cationic detergent to break down cell membranes and contain contamination or interference from compounds such plant secondary metabolites. We have modified the CTAB protocol to suit DNA isolation from different tissue types. We found that by adjusting the percentage of CTAB in combination with modifying subsequent washing steps, total DNA recovery is optimized and increased. For plants, this protocol has been used with different solanaceous plants such asCapsicum annuum,Nicotiana benthamiana,Nicotiana tabacum,Solanum lycopersicum, andSolanum tuberosum, whose phenolic acid content is usually an obstacle to obtaining genomic DNA free of contamination. This protocol has also been used withArabidopsis thaliana, Marchantia polymorpha,Oryza sativa, and differentCitrusandPopulusspecies. For animals, this protocol has been used with root-knot nematodes (Meloidogynespp.), cyst nematodes (GloboderaandHeteroderaspp.), aphids, mites, and thrips. This protocol has also been used with mammalian hair follicles and sperm. For fungi, this protocol has been used with mycelia of different fungal genera. This protocol allows for standardization of DNA extraction, optimization with regard to tissue type, and improved repeatability across studies.
Effect of sarcopenic obesity on treatment results in patients with malignant tumors of the gastrointestinal tract: systematic review
Authors: Boldyreva T. S. , Lyadov V. K.
Published: January 2025

Background. Tumors of the gastrointestinal (GI) tract are characterized by high morbidity and poor prognosis. Over the past decade, sarcopenia (skeletal muscle depletion), myosteatosis, sarcopenic obesity were all shown to have negative prognostic effect in patients with various GI malignancies. However, the role of sarcopenic obesity (SO) in patients with GI tumors remains controversial. We have summarized clinical trial data on the effect of SO on treatment results in patients with malignant GI tumors who underwent surgical and/or drug antitumor treatment.

Materials and methods. Thisstudy was conducted in comliance with the Preferred Reporting Itemsfor Systematic Review and Meta-Analyses (PRISMA) guidelines. PubMed and Cochrane Library databases were searched for relevant original studies published between January 2009 and December 2022 reporting postoperative complication rate and mortality, long-term survival and chemotherapy toxicity in SO patients with GI cancers.

Results. Twenty four studies with 9,601 patients were included. The percentage of SO patients ranged from 2.6 to 51 %. Due to significant heterogeneity of SO determination methods and varying threshold values, the association between SO and outcomes of interest was inconsistent. SO was significantly associated with development of major postoperative complications in six studies. In contrast, three studies did not show any effect of SO on postoperative complications. Only two studies demonstrated that the mortality rate was significantly higher among patients with SO compared to those without SO. Four studies using multivariate analysis showed statistically significant effect of SO on long-term survival, one study – on disease-free survival. However, three trials contradicted this finding and reported that SO was not a negative prognostic factor of long-term survival in GI cancer patients. Three studies investigating SO effect on the outcomes of drug antitumor treatment showed negative effect of SO on chemotherapy toxicity.

Conclusion. There is considerable heterogeneity in methods used to define SO in the literature, and current data is limited. Standardized terminology and deeper understanding of sarcopenic obesity pathophysiology is needed to further understand the effect of obesity and sarcopenia on clinical trajectory of patients with GI cancer.
Exploring Conventional Approaches for Color Image Denoising: A Comparative Study
Authors: D. Uppalapati Nagasubhadra
Published: January 2025

Image denoising plays a critical role in enhancing the quality of digital images by removing unwanted noise while preserving important image details. Among various noise types, color image denoising presents unique challenges due to the complex correlation between color channels. This paper explores conventional denoising approaches specifically tailored for color images, focusing on well-established techniques such as median filtering, Gaussian smoothing, bilateral filtering, Non-Local Means (NLM), and wavelet-based denoising. Each method is analyzed for its effectiveness in suppressing noise while maintaining image integrity. We perform a comparative study to evaluate the performance of these techniques across different noise models, including Gaussian, salt-and-pepper, and speckle noise. Objective metrics such as Peak Signal-to-Noise Ratio (PSNR) and Root Mean Square Error (RMSE) are used to assess image quality post-denoising. Our results highlight the strengths and limitations of each method, offering insights into which conventional approaches are most suitable for specific noise types and image content. This comparative analysis serves as a foundation for further research and development of advanced denoising techniques.
Characteristics of polymorphism of genes involved in the regulation of glucose metabolism and steroid hormone synthesis in patients with polycystic ovary syndrome
Authors: Osinovskaya Natalia S. , Abashova Elena I. , Yarmolinskaya Maria I. , Bredgauer Maria D. , Sultanov Iskender Yu. , Nasykhova Yulia A. , Glotov Andrey S.
Published: January 2025

Background: Polycystic ovary syndrome is an urgent problem of gynecological endocrinology. Currently, a number of genes have been studied that control glucose metabolism and are involved in the synthesis, conversion into an active form and transport of steroid hormones, mutations in which with a certain degree of reliability can serve as a diagnostic criterion for polycystic ovary syndrome.
Aim: The aim of this study was to evaluate the PPARG Pro12Ala, INS 223HphI AT, and SHBG (TAAAA)n gene polymorphisms in patients with polycystic ovary syndrome and in healthy individuals.
Materials and methods: The polymerase chain reaction method and restriction fragment length polymorphism analysis were used. The frequencies of alleles and genotypes of polymorphic variants were studied in 136 women with polycystic ovary syndrome and 47 women in the control group: Pro12Ala (PPARG gene), 223HphI AT, (INS gene) and (TAAAA)n repeats (SHBG gene).
Results: The distribution of the allele and genotype frequencies for the PPARG (rs1801282) and INS (rs689) genes in patients with polycystic ovary syndrome and in healthy individuals did not differ. The distribution of the genotype frequencies in the group of women with polycystic ovary syndrome differed (p = 0.02) from that in the control group for the (TAAAA)n polymorphism in the SHBG gene. In the presence of a long repeat in the SHBG gene in at least one of the homologous chromosomes, the probability of a woman having polycystic ovary syndrome increases by 2.5 times. Patients with a verified A/A genotype (INS), in the presence of an SHBG gene allele with a long repeat, have a ten-fold higher risk of developing polycystic ovary syndrome than women with SHBG gene short alleles.
Conclusions: Patients with long repeats in the SHBG gene are at risk for developing polycystic ovary syndrome with phenotypes A, B, and C, especially in combination with the presence of the A/A genotype, class I (INS).
The effect of hyaluronic acid-enriched transfer medium on the implantation rate in frozen-thawed embryo transfer cycles
Authors: Lesik Elena A. , Komarova Evgenia M. , Ishchuk Mariia A. , Ob’edkova Ksenia V. , Sagurova Yanina M. , Safarian Galina Kh. , Makhmadalieva Manizha R. , Milyutina Yuliya P. , Gzgzyan Alexander M. , Tapilskaya Natalia I. , Bespalova Olesya N.
Published: January 2025

Background: The treatment strategy for patients with a history of multiple failures in in vitro fertilization cycles remains a subject of active research. Embryo transfer in cryocycles is known to be more successful than “fresh” embryo transfer, when ovarian stimulation, follicle puncture, fertilization, and embryo culture were performed but the overall efficiency of in vitro fertilization cycles decreases with maternal age and transfer of poor quality embryos. One of the key factors influencing the failure of high quality embryo implantation is the deficiency of the adhesive matrix, which ensures the interaction between the embryo and the endometrium. The implementation of protocols that include the use of hyaluronic acid-enriched transfer media in the process of embryo transfer is a promising direction for improving implantation outcomes. Special attention of researchers is paid to determining the indications for the use of this technique.
Aim: The aim of this study was to evaluate the effect of hyaluronic acid-enriched transfer media on the pregnancy rate in cryocycles.
Materials and methods: This retrospective cohort comparative study, included 609 women who underwent controlled ovarian stimulation and frozen-thawed embryo transfer.
Results: The main outcomes of frozen-thawed embryo transfer cycles were analyzed, taking into account the quality of the transferred embryos and the use of hyaluronic acid-enriched transfer media. The latter was not shown to be associated with an increase in biochemical and clinical pregnancy rates in women under 35 years of age with a history of repeated implantation failures or after transfer of poor quality embryos. However, in patients over 40 years of age with poor quality embryos, the use of hyaluronic acid-enriched transfer media was effective, since it increased the clinical pregnancy rate. As expected, our data showed an increase in the clinical pregnancy rate in women with high quality embryos on the day of transfer, regardless of the patient’s age. At the same time, in patients with a thin (thickness less than 7 mm) endometrium or a history of miscarriage, the use of hyaluronic acid-enriched transfer media was also associated with an increase in the clinical pregnancy rate and live birth during embryo transfer in cryocycles.
Conclusions: The data obtained have shown that the use of hyaluronic acid-enriched transfer media in cryocycles may be recommended for women over 40 years of age, regardless of the quality of the transferred embryos, as well as for women of any reproductive age with a thin endometrium and a history of miscarriage when transferring good quality embryos.
Assessment of the current knowledge of obstetricians and gynecologists about preconception screening. A sociological survey
Authors: Postnikova Tatiana B. , Mikhailova Anastasiia A. , Bespalova Olesya N. , Talantova Olga E. , Glotov Andrey S.
Published: January 2025

Background: Preconception screening is testing for carriage of recessive mutations of monogenic diseases in healthy spouses at the stage of pregnancy planning. In the Russian Federation, genetic testing and subsequent consultation by obstetricians and gynecologists are only carried out in two or three specialized centers. Obstetricians and gynecologists of the outpatient care service as the primary level of prevention do not often have information about these diseases and know where to refer patients for examination. It is not their responsibility to provide advice on this matter, but they should know the genetic centers where the patient or couple can be referred for further consultation. Increasing the level of knowledge of obstetricians and gynecologists will allow the widespread introduction of preconception screening as the primary stage of the prevention of hereditary diseases.
Aim: The aim of this study was to determine, based on the analysis of questionnaire data, the current level of knowledge and interest of obstetricians and gynecologists regarding issues of preconception screening.
Materials and methods: This study was conducted in the categorical field of medical sociology as one-time continuous research. A hundred of obstetricians and gynecologists from St. Petersburg, Russia who work in antenatal clinics, hospitals and private medical institutions participated in this sociological study on a voluntary and anonymous basis. To conduct the survey, an original questionnaire was developed, which included 21 questions. The survey was carried out using an electronic questionnaire (Google form).
Results: As a result of the survey, a hundred of obstetricians and gynecologists took part, including local doctors at district antenatal clinics, inpatient doctors, heads of departments, as well as obstetricians and gynecologists from private medical organizations. Analysis of the sociological survey data showed a satisfactory level of theoretical knowledge of obstetricians and gynecologists regarding preconception screening. At the same time, there is no general algorithm for managing data of the patients, their routing, and the scope of examination and diagnosis.
Conclusions: Our study emphasizes that the problem of preconception screening is relevant and requires a deeper understanding by obstetricians and gynecologists. The development of a methodological manual for obstetricians and gynecologists will increase the level of awareness of specialists, optimize the routing of potential patients and increase the effectiveness of the prevention of hereditary diseases with a recessive type of inheritance.
Microalbuminuria, neutrophil gelatinase-associated lipocalin (NGAL), and kidney injury molecule-1 (KIM-1) as predictors of preeclampsia and gestational diabetes mellitus
Authors: Bezhenar Vitaliy F. , Grigoreva Olesia A. , Galkina Olga V. , Anpilova Anastasiia O.
Published: January 2025

Background: The health of young women of reproductive age is a key factor that directly influences the health of future generations. Therefore, early detection of chronic diseases, including chronic kidney disease, in this category of patients is one of the primary objectives of healthcare services. From an obstetric perspective, preventing chronic kidney disease can be linked to the early detection and prediction of preeclampsia and gestational diabetes mellitus. In the literature, there are studies that investigate microalbuminuria, neutrophil gelatinase-associated lipocalin (NGAL), and kidney injury molecule-1 (KIM-1) as predictors of these obstetric complications.
Aim: The aim of this study was to evaluate microalbuminuria, KIM-1, and NGAL as markers for the development of gestational diabetes mellitus and preeclampsia.
Materials and methods: This prospective study was conducted at the Department of Obstetrics and Gynecology, Academician I.P. Pavlov First Saint Petersburg State Medical University (Saint Petersburg, Russia) and involved 280 pregnant women during the first trimester at 6-13 weeks of gestation. The concentrations of microalbuminuria, KIM-1, and NGAL were measured. The second stage involved assessing the course of pregnancy and the development of obstetric complications in the participants. ROC analysis was performed to assess biological markers as predictors of preeclampsia, and predictive value was evaluated by the area under the ROC curve.
Results: The urinary KIM-1 levels in all patients were within the reference values. Microalbuminuria in the range from 30 to 300 mg/L was detected in 20 patients (7.14%). Gestational diabetes mellitus was more common in patients with microalbuminuria above 30 mg/L (p = 0.0358). Elevated serum NGAL levels above the reference values (106 ng/L) were observed in 96 patients (34.2%). Urinary NGAL levels exceeded 9.8 ng/L in 203 patients (72.5%). Moderate or severe preeclampsia developed in 63 (22.5%) pregnant women. ROC analysis of NGAL’s predictive ability showed high sensitivity and specificity for preeclampsia prediction (sensitivity 95.24%, specificity 93.09%, area under the ROC curve 0.93).
Conclusions: The data obtained suggest that the assessment of albuminuria, serum NGAL, and urinary NGAL levels in the blood serum and urine of pregnant women during the first trimester of gestation may serve as early prognostic biomarkers for gestational diabetes mellitus and preeclampsia.
edición milanesa, sin año, de La Diana como clave para la datación de la muerte de Montemayor
Authors: Montero Delgado Juan
Published: January 2025

Aunque no se ha podido probar documentalmente, la muerte de Montemayor suele fecharse en febrero de 1561, en el Piamonte. En paralelo, la edición milanesa, sin año, de La Diana, impresa en vida del autor con su participación, suele fecharse en 1560. Sin embargo, la evidencia textual de que esta edición deriva de la impresa en Barcelona, 1561 (colofón: 21 de enero) imposibilita de hecho que el escritor muriese en la fecha habitualmente aceptada. Hay que pensar, más bien, que esa Diana se imprimió a finales de 1561 o principios de 1562, y que el escritor murió probablemente en febrero, sí, pero de 1562.