bluuebunny/crossref_metadata_2025 huggingface dataset:
Germinated Brown Rice Protects H9c2 Cardiomyocyte against Simulated Ischemic/Reperfusion Injury via Mediated Mitochondria Function
Authors: Demeekul Kanokwan , Suthammarak Wichit , Petchdee Soontaree
Published: May 2020

Background

Ischemia/reperfusion (I/R) injury is the major mechanism during Ischemic Heart Disease (IHD). The key modulator of I/R injury is dysregulation of mitochondria function. Germinated Brown Rice (GBR) has recommended as a bio-functional food and has clarified the potential properties in several effects. However, the effect of GBR mediated cardioprotective properties, focusing on the role of mitochondrial function, remains unexplored. Thus, this study aims to investigate the cardioprotective effects of GBR pretreatment against simulated I/R injury.
Results

H9c2 cardiomyocytes were incubated with GBR at a concentration of 5 ƞg/ml for 24 hours and/or simulated I/R (sI/R) for 40 minutes. Cell viability and cell apoptosis were assessed by 7-AAD staining and AnnexinV/PI staining, respectively. For evaluation of mitochondrial functions, not only mitochondrial membrane potential was determined by JC-1 staining but also mitochondrial respiration was represented by oxygen consumption rate (OCR) using Seahorse Flux analyzer. The results revealed that administration of GBR prior to sI/R significantly decreased the percentage of cell death and total cell apoptosis in H9c2 during stimulation of ischemic/reperfusion. In addition, pretreatment of cardiomyocytes with GBR remarkably stabilized mitochondrial membrane potential and improved impaired mitochondrial respiration in simulated-H9c2 injury.
Conclusion

the present research is the first study to report the effective cardioprotection of GBR. Pretreatment of GBR potentially protects H9c2 cardiomyocytes against sI/R injury through mitochondrial function. The underlying therapeutic activities are possibly associated with its bio-functional compounds. However, the underlying mechanism on cardioprotective effects of GBR needs further studies.
Endotracheal tube cuff pressure – how fast paramedics can learn the optimal inflation? - comparison of different methods
Authors: Ilczak Tomasz Piotr , Cwiertnia Michal Tomasz , Bialon Piotr , Szlagor Michal , Kudlacik Beata , Rak Małgorzata , Bialka Szymon , Ubych Adam , Stasicki Arkadiusz , Waksmanska Wioletta , Bujok Jan , Mikulska Monika , Bobinski Rafal , Kawecki Marek Stanisław
Published: May 2020

Background

Tracheal intubation is the optimal method for opening up the airways. Performed correctly, it prevents stomach contents from entering the respiratory tract, and allows asynchronous CPR to be conducted during sudden cardiac arrest. An important element of correct intubation is proper inflation of the endotracheal tube cuff. Research has shown that when medical personnel use the palpation technique, the cuff is usually inflated incorrectly. This can result in numerous health complications for the patient.
Methods

This research was conducted in 2020 on a group of paramedics participating in the 15th International Winter Championship of Medical Rescuers in Bielsko-Biała. The aim of the research was to assess two methods of inflating the endotracheal tube cuff. Method A involved inflating the cuff using a syringe and assessing the pressure in the control cuff using the palpation technique. Method B involved inflating the cuff using a manometer. During the inflation, both the cuff inflation pressure and the time required to complete the procedure were recorded. Analysis was also conducted on whether completion of certified ALS and ACLS training had any influence on the effectiveness of the inflation procedure.
Results

The research showed that paramedics using method B significantly more often inflated the endotracheal tube cuff to the correct pressure than those using method A. However, when method B was used, the procedure took longer to conduct. The study also showed that completion of certified ALS or ACLS training did not have a significant influence on proper inflation of the cuff. Those who had completed certified training courses took significantly longer to inflate the endotracheal tube cuff when using method A.
Conclusions

Inflation of the endotracheal tube cuff by use of a syringe, followed by the palpation technique for assessing the inflation of the cuff balloon is ineffective. Paramedic teams should be equipped with manometers to be used for inflating the endotracheal tube cuff.
Treatment Failure with combined csDMARDs increases the risk of Low Muscle Mass in women with Rheumatoid Arthritis: a cross-sectional study
Authors: Ramirez-Villafaña Melissa , Rodriguez-Jimenez N Alejandra , Gamez-Nava Jorge I , Aceves-Aceves Javier A , Saldaña-Cruz Ana M , Cardona-Muñoz Ernesto G. , Totsuka-Sutto Sylvia E , Ponce-Guarneros J Manuel , Cons-Molina Fidencio , Trujillo Xochitl , Huerta Miguel , Cruz-Jentoft Alfonso J , Gonzalez-Lopez Laura
Published: May 2020

Background Low muscle mass (myopenia) is frequent in rheumatoid arthritis (RA) patients with a long-disease duration. Although, the use of combined therapy with conventional synthetic DMARDs (csDMARDs) is one of the main strategies observed in these patients; there is a lack of information if the failure to these therapies increases the risk of myopenia. Objective: To evaluate whether the treatment failure to combined therapy with conventional synthetic DMARDs is an independent risk factor for low skeletal muscle mass in women with RA. Methods This cross-sectional study compared 277 women with RA (cases) and 237 women from non-rheumatic population (controls). In RA patients, we assessed clinical, epidemiological, and therapeutic variables (identifying treatment failure to combined therapy with csDMARDs. The skeletal muscle index (SMI) was estimated by DXA. Low skeletal muscle mass was defined as SMI<5.45 kg/m2. Multivariate logistic regression analyses were used to a) evaluate whether RA is an independent risk factor of myopenia in comparison with non-rheumatic population and b) identify if treatment failure with csDMARDs is an independent risk factor of myopenia in RA. Results RA patients had a higher prevalence of low skeletal muscle mass than controls (27.8% vs. 15.6%, p=0.001). After adjusting for other factors, RA patients had higher risk of low skeletal muscle mass than controls (OR: 2.7, 95%CI:1.7 to 4.5). Risk factors of low muscle mass in RA patients; were: menopause (OR: 2.3, 95%CI: 1.2 to 4.6, p=0.02) and a failure to combined therapy with csDMARDs (OR: 2.4, 95%CI: 1.10 to 5.81, p=0.03). Conclusions Rheumatoid arthritis is associated with an increased risk of myopenia. Treatment Failure with conventional-synthetic DMARDs constitutes a strong risk factor for deteriorated skeletal muscle mass.
Quality of Work Life and Associated Factors among Nurses Working in Wollega Zones Governmental Hospitals, West Ethiopia, 2018
Authors: Mosisa Getu , Abadiga Muktar , Oluma Adugna , Wakuma Bizuneh
Published: May 2020

Background Quality of work-life refers to the extent to which members of a work organization can satisfy their personal needs through their work experience in the organization. High quality of working life is critical for healthcare organizations to attract and retain qualified, committed and motivated employees and also lead to high task performance. However, there are few studies regarding quality of work life among nurses in Ethiopia. The objective of this study was to assess quality of work life and associated factors among nurses working in Wollega Zones governmental hospitals, 2018.Methods Institutional based cross - sectional study design was conducted on 212 nurses working in wollega zones governmental hospitals from November to December, 2018. The study participants were selected by using simple random sampling techniques. The data was entered into Epi data version 3.1 and then exported into Statistical Package for the Social Sciences window version 20.0 for analysis. Multiple regression analysis was conducted to identify factors associated with quality of working life of nurses. Statistical significance was declared at p<0.05.Result A total of 212 nurses were involved in the study. The study revealed that about 108(50.5% of nurses have good quality of work life. Income and dependent family were significantly associated with quality of work life. In this study, Nurses who have no dependent family were 2.72 (AOR 2.72, 95% CI: 1.38, 5.38) times more likely to have good quality of work life compared to those who have dependent family. Nurses whose monthly income 446-5294 were 2.39(AOR 2.39 95% CI: 1.08, 5.37) times more likely to have good quality of work life compared to those who got less than 3653.Conclusion Nearly half of nurses were dissatisfied with the quality of their work life . The study revealed that monthly income and presence of dependent family showed significant association with quality of work life. Bringing up and maintaining a higher level of quality of work life among nurses is a key to promote job satisfaction and enhance quality of patient care.
Factors associated with patient satisfaction with perioperative anesthesia care at Hawassa university comprehensive specialized hospital, Ethiopia: Cross-sectional study design
Authors: Siraneh Amanu Gashaw , Welda Getahun Dendir , Chanko Kebreab Paulos
Published: May 2020

Background

Patient satisfaction in relation to perioperative anesthesia care represents an essential aspect of quality health care management. The assessment of patient satisfaction is a reality of practice today for good patient satisfaction with health care provider interaction and health influencing factors.
Objectives

To assess the magnitude and associated factor of patient satisfaction towards anesthesia care at Hawassa University comprehensive specialized Hospital April 5, – May 5, 2019Gc.
Method:

A prospective cross-sectional study design was employed in an adult surgical patient scheduled for surgery under general anesthesia and the regional anesthesia level of satisfaction and factor associated with satisfaction was analyzed. Data was entered info version 7 and transfer to SPSS version 25 .0 for analysis. Normality test checked by using Shapiro-Wilk and Kolmogorov-Smirnov the data was normally distributed. Then the frequency, percentage, and cross-tabulation with different variables were determined, lastly, the magnitude and associated factor analyzed by binary logistic regression a multivariate logistic regression. Variables P-value < 0.2 binary logistic regression included in a multivariate logistic regression and p_value less than 0.05 was Taken as statistically significant.
Result

A Total of 200patient included in this study with a response rate of 100%. The main finding of this study was predictors of perioperative patient dissatisfaction were general anesthesia, duration of surgery, nausea, and vomiting, and pain after surgery. The magnitude of patient satisfaction is 60%. Odds of the patient who took general anesthesia were 2.31(1.096, 4.142) p = 0.026 more dissatisfied than regional anesthesia. Odds of the patient duration of surgery 2-3hr 0.313(0.124, 0.792) less likely dissatisfied than the duration of surgery 1hr.The odds of patient nausea and vomiting AOR = 2.575(1.163, 5.698) P = 002 more likely dissatisfied than didn’t have nausea and vomiting. The odds of patient pain after surgery AOR = 2.28(1.084, 4.76) more likely dissatisfied than the patient didn’t have pain after surgery.
Conclusion

patient satisfaction with perioperative anesthesia care Compared to another study magnitude of satisfaction very low, regular study and intervention should do every time /year in order to increase patient satisfaction.
Quantum Gene Chain Coding Bidirectional Neural Network for Residual Useful Life Prediction of Rotating Machinery
Authors: Li Feng , Cheng Yang-Yang , Tang Bao-Ping , Zhou Xue-Ming , Xiong Rui-Ping
Published: May 2020

In classical recurrent neural networks, the pre- and post-relationships of time series tend to be neglected so that long-term overall memory is generally inaccessible; meanwhile, the weights are transferred and updated mainly by the gradient descent method, which leads to their low prediction accuracy and high computation cost in the application of residual useful life (RUL) prediction of rotating machinery (RM). In view of this, a quantum gene chain coding bidirectional neural network (QGCCBNN) is proposed to predict RUL of RM in this paper. In our proposed QGCCBNN, the quantum bidirectional transmission mechanism is designed to establish the pre- and post-relationships of time series for readjusting the weight parameters according to the feedback from the output layer, so that higher consistency between the input information and the overall memory of the network can be realized, thus endowing QGCCBNN with better nonlinear approximation ability. Moreover, in order to improve the global optimization ability and convergence speed, the quantum gene chain coding instead of gradient descent method is constructed to transmit and update data, in which the qubit probability amplitude real number coding is adopted and the cosine and sinusoidal qubit probability amplitudes corresponding to the minimum loss function are compared with those of the current time by the phase selection matrix for the directional parallel updating of the weight parameters. On this basis, a new RUL prediction method for RM is proposed, and higher prediction accuracy as well as desirable efficiency can be obtained due to the advantages of QGCCBNN in nonlinear approximation ability and convergence speed. The experimental example for RUL prediction of a double-row roller bearing demonstrates the effectiveness of our proposed method.
The impact of COVID-19 on pregnancy and neonatal health: a systematic review
Authors: Mirbeyk Mona , Rezaei Nima
Published: May 2020

Background: In December 2019, a novel coronavirus disease (COVID-19) emerged in Wuhan, China. With an incredible rate of contagion, it has reached all over the world, with more than 2 million confirmed cases at the mid of April. However, the vertical transmission of COVID-19 is uncertain. This is a systematic review of published studies concerning pregnant women with confirmed COVID-19 and their neonates.Methods: We performed a systematic search in Pubmed, Web of Sciences, Google Scholar, Scopus, and World Health Organization (WHO) COVID-19 database to find articles reporting clinical data of COVID-19-positive pregnant women and their neonates.Results: 37 articles, involving 364 pregnant women with COVID-19 and 302 neonates, were included. The vast majority of pregnant patients were in their third trimester of pregnancy, and only 45 cases were in the first or second trimester (12.4%). Most mothers described mild to moderate manifestations of COVID-19. Of 364 pregnant women, 25 were asymptomatic at the time of admission. The most common symptoms were fever (62.4%) and cough (45.3%). Two maternal deaths occurred. Some pregnant patients (12.1%) had a negative SARS‐CoV‐2 test but displayed clinical manifestations and abnormalities in computed tomography (CT) scan related to COVID‐19. Twenty‐two (6.0%) pregnant patients developed severe pneumonia. Two maternal deaths occurred from severe pneumonia and multiple organ dysfunction. Studies included a total of 302 neonates from mothers with COVID‐19. Of the studies that provided data on the timing of birth, there were 65 (23.6%) preterm neonates. One baby was born dead from a mother who also died from COVID-19. Of the babies born alive from mothers with COVID‐19, five newborns faced critical conditions, and two of which later died. A total of 219 neonates underwent nasopharyngeal specimen collection for SARS‐CoV‐2, of which 11 tested positive (5%). Seventeen studies examined samples of the placenta, breast milk, umbilical cord, and amniotic fluid, and all tested negative except one amniotic fluid sample.Conclusions: A systematic review of published studies confirm that the course of COVID-19 in pregnant women resembles that of other populations. However, there is not sufficient evidence to establish an idea that COVID-19 would not complicate pregnancy.
Structure-Based Screening of Novel Lichen Compounds for SARS Coronavirus Main protease (Mpro) and Angiotensin-Converting Enzyme 2 (ACE2) inhibitory potentials as multi-target inhibitors of COVID-19
Authors: Joshi Tanuja , Sharma Priyanka , Joshi Tushar , Pundir Hemlata , Mathpal Shalini , Chandra Subhash
Published: May 2020

Outbreak of SARS-CoV-2 and massing death caused by it all over world has imposed great concern on scientific community to develop potential drugs to combat with Coronaviruas disease 19 ( COVID-19 ). In this regard, lichen metabolites may offer a vast reservoir for discovery of anti-viral drug candidates. Therefore to find novel compounds against COVID-19, we created a library of 412 lichen compounds and subjected to virtual screening against two molecular targets; SARS-CoV-2 target- Main protease (Mpro) and host cell target- Angiotensin-converting enzyme 2 (ACE2). All the ligands were virtually screened, and 80 compounds were found to have better docking score with both the targets. These compounds were assessed for druglikeness analysis where 27 compounds were found to fit well for redocking studies. The results of redocking by X-Score showed that 7 out of 27 compounds were found to have high affinities with Mpro as well ACE2 which reflect that these compounds can function as dual inhibitors. Molecular docking, druglikeness, X-Score and toxicity analysis resulting seven novel lichen compounds (Orcinyllecanorate, Siphulin, Fremontol, Gyrophoric acid, Rhizocarpic acid, Ovoic acid, and Umbilicaric acid) with Mpro and ACE2 multi-target activities and they can be used as hit compounds to develop potential antiviral agents against SARS-CoV-2. These lichen compounds may be a suitable candidate for further experimental analysis.
Acute Pulmonary Embolism In Non-Hospitalized Covid-19 Patients Referred To CTPA By Emergency Department
Authors: Alban GERVAISE , Caroline BOUZAD , Evelyne PEROUX , Carole HELISSEY
Published: May 2020

Objectives: To evaluate the prevalence of acute pulmonary embolism (APE) in non-hospitalized COVID-19 patients referred to CT pulmonary angiography (CTPA) by Emergency Department.Methods: From March 14 to April 6, 2020, 72 non-hospitalized patients referred by Emergency Department to CTPA for COVID-19 pneumonia were retrospectively identified. Relevant clinical and laboratory data and CT scan findings were collected for each patient. CTPA scans were reviewed by two radiologists to determinate the presence or absence of APE. Clinical classification, lung involvement of COVID-19 pneumonia and CT total severity score were compared between APE group and Non-APE group.Results: APE was identified in 13 (18%) CTPA scans. The mean age and D-dimer of patients from APE group were higher in comparison with Non-APE group (74.4 vs. 59.6 years, p=0.008 and 7.29 vs. 3.29 µg/ml, p=0.011). There was no significant difference between APE and Non-APE groups concerning clinical type, COVID-19 pneumonia lung lesions (ground-glass opacity: 85 vs. 97%; consolidation: 69 vs. 68%; crazy paving: 38% vs. 37%; linear reticulation: 69 vs. 78%), CT severity score (6.3 vs. 7.1, p=0.365), quality of CTPA (1.8 vs. 2.0, p=0.518) and pleural effusion (38% vs. 19%, p=0.146).Conclusions: Non-hospitalized patients with COVID-19 pneumonia referred to CT-scan by Emergency Departments are at risk of APE. Presence of APE was not limited to severe or critical clinical type of COVID-19 pneumonia.
Broad-spectrum inhibition of coronavirus main and papain-like proteases by HCV drugs
Authors: Anson Brandon J. , Chapman Mackenzie E. , Lendy Emma K. , Pshenychnyi Sergii , D’Aquila Richard T. , Satchell Karla J. F. , Mesecar Andrew D.
Published: May 2020

Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has led to over 200,000 deaths thus far. We screened a library of approved antiviral drugs against the two SARS-CoV-2 proteases, 3C-like/main protease (3CLpro/Mpro) and papain-like protease (PLpro), which are essential for viral replication and attractive drug targets. Three HCV protease inhibitors were tested and found to inhibit 3CLpro and PLpro enzymes from Alpha-, Beta- and Gamma-coronaviruses. Anti-HIV drugs had no activity. Boceprevir and telaprevir inhibited 3CLpro, with boceprevir inhibiting eight of nine coronavirus 3CLpro enzymes tested including from SARS-CoV-2, MERS and SARS-CoV. Asunaprevir inhibited PLpro from SARS-CoV-2 and four other coronaviruses. The 1.4 Å X-ray structure of boceprevir bound to 3CLpro was determined to explain its broad-spectrum activity and guide structure-based design of inhibitors of multiple coronaviruses.Authors Brandon J. Anson, Mackenzie E. Chapman, and Emma K. Lendy contributed equally to this work.
Pengembangan Perangkat Pembelajaran Matematika dengan Pendekatan Matematika Realistik pada Pokok Bahasan Tabung untuk SMP Negeri 2 Nanga Taman Kelas IX
Authors: Yupinus Lusius , Ichsan Ichsan , Ardiawan Yadi
Published: May 2020

Tujuan dalam penelitian pengembangan ini adalah untuk mendapatkan desain pengembangan perangkat pembelajaran matematika berupa RPP dan LKS dengan pendekatan matematika realistik pada pokok bahasan tabung untuk SMP Negeri 2 Nanga Taman kelas IX. Selain itu, penelitian ini juga bertujuan untuk menguji tingkat kevalidan, kepraktisan, dan keefektifan perangkat pembelajaran dengan pendekatan matematika realistik pada pokok bahasan tabung. Penelitian ini merupakan penelitian pengembangan dengan model pengembangan 4-D yang meliputi define, design, develop, dan dissemination. Hasil penelitian menunjukkan bahwa berdasarkan penilaian ahli materi, ahli media, dan guru matematika perangkat pembelajaran yang dikembangkan memiliki kriteria sangat valid dengan rata-rata total skor 190,33 untuk RPP dan 297,5 untuk LKS. Berdasarkan pada hasil pengisian angket respon siswa dan angket respon guru dapat disimpulkan bahwa perangkat pembelajaran yang dikembangkan memiliki kriteria sangat praktis dalam penggunaannya dengan rata-rata total skor 91,1 untuk angket respon siswa dan jumlah 84 untuk angket respon guru. Sedangkan, berdasarkan pada hasil pengisian observasi keterlaksanaan pembelajaran dan hasil tes evaluasi hasil belajar dapat disimpulkan bahwa perangkat pembelajaran yang dikembangkan memiliki tingkat keefektifan yang yang sangat baik dengan persentase keterlaksanaan pembelajaran 94,87% dan persentase ketuntasan siswa 95 %.

Kata kunci: matematika realistik, perangkat pembeljaran, tabung.
KONTROVERSI JIDAT HITAM DI MADURA: Studi Penafsiran Komparatif-Sektarian QS. al-Fatḥ [48]: 29
Authors: Zamzami Mohammad Subhan
Published: May 2020

This paper reveals athar al-sujūd’s interpretation in QS. al-Fatḥ [48]: 29 behind the controversy of the stigma of black foreheads against certain groups in Islam. This paper is a result of literature and fieldwork research based on comparative interpretation methods (tafsīr muqārin) on five tafsīr books from different schools and interviews with some figures from different religious organizations in Madura. This research has discovered that the controversy from the stigma of a black forehead was not only triggered by different interpretations of athar al-sujūd in QS. al-Fatḥ [48]: 29, but also by several hadiths narrated by Aḥmad, al-Bayhaqī, and al-Bukhārī, which cause controversy among Muslims in Madura. In fact, no group in Islam wants such controversy, either as the subject of the accuser or the accused as a group of black foreheads.
PENGARUH PROMOTION MOTIVATIONAL SYSTEM, PREVENTION MOTIVATIONAL SYSTEM DAN RISK PREFERENCE TERHADAP PEMBENTUKAN PORTOFOLIO INVESTASI BERISIKO
Authors: Kurniawan Wahyu Aji , Dewanti Patriani Wahyu
Published: May 2020

Abstrak: Pengaruh Promotion motivational System, Prevention Motivational System, dan risk Preference Terhadap Pembentukan Portofolio Investasi Berisiko. Penelitian ini bertujuan untuk mengetahui: (1) Apakah terdapat perbedaan pembentukan portofolio investasi berisiko antara individu dengan promotion motivational system dan prevention motivational system, (2) Pengaruh promotion motivational system terhadap pembentukan portofolio investasi berisiko, (3) Pengaruh prevention motivational system terhadap pembentukan portofolio investasi berisiko, dan (4) Pengaruh risk preference terhadap pembentukan portofolio investasi berisiko. Teknik pengumpulan data yang digunakan adalah purposive sampling. Uji hipotesis yang digunakan adalah uji independent sample t-test dan uji analisis regresi linier sederhana. Hasil penelitian menunjukkan bahwa: (1) Terdapat perbedaan pembentukan portofolio investasi berisiko antara individu dengan promotion motivational system dan prevention motivational system, (2) Promotion motivational system tidak berpengaruh terhadap pembentukan portofolio investasi berisiko, (3) Prevention motivational system tidak berpengaruh terhadap pembentukan portofolio investasi berisiko, (4) Risk preference tidak berpengaruh terhadap pembentukan portofolio investasi berisiko.Kata Kunci: Promotion Motivational System, Prevention Motivational System, Risk Preference, Pembentukan Portofolio Investasi Berisiko.
DETERMINAN MOTIVASI KERJA PEGAWAI DAN KINERJA PANTI ASUHAN DI YOGYAKARTA
Authors: Pratolo Suryo , Binary Javanti , Sofyani Hafiez
Published: May 2020

Abstrak: Determinan Motivasi Kerja Pegawai dan Kinerja Panti Asuhan di Yogyakarta. Penelitian ini bertujuan untuk menguji pengaruh akuntabilitas, budaya organisasi dan kepemimpinan etis terhadap motivasi kerja pegawai dan terhadap kinerja panti asuhan. Penelitian ini menggunakan pendekatan uji korelasi yang berguna untuk menjelaskan ada tidaknya hubungan antar variabel. Dalam penelitian ini sampel terdiri dari 30 panti asuhan dipilih menggunakan teknik random sampling. Uji korelasi dengan teknik analisis regresi berganda digunakan untuk menguji hipotesis. Sebelum kami menguji hipotesis, analisis faktor dan uji asumsi klasik dilakukan untuk menguji validitas dan reliabilitas instrumen dan kualitas data. Hasil penelitian menunjukkan bahwa budaya organisasi dan kepemimpinan etis berpengaruh positif terhadap motivasi kerja karyawan panti asuhan dan kinerja panti asuhan. Sedangkan akuntabilitas hanya secara positif memengaruhi kinerja panti asuhan dan tidak terhadap motivasi kerja karyawan panti asuhan.Kata kunci: akuntabilitas, kepemimpinan etis, komitmen organisasi, budaya organisasi, kinerja organisasi, kepemimpinan transformasional, motivasi kerja
PERAN RELIGIUSITAS DAN BATASAN WAKTU AUDIT TERHADAP EFEKTIVITAS FUNGSI INTERNAL AUDIT DI BMT KARISMA MAGELANG
Authors: Nurcahya Yulida Army , Ismawati Ema , Bharata Risma Wira
Published: May 2020

Abstrak: Peran Religiusitas Dan Batasan Waktu Audit Terhadap Efektivitas Fungsi Internal Audit Di BMT Karisma Magelang Penelitian ini bertujuan untuk mengetahui peran religiusitas dan batasan waktu audit terhadap efektivitas fungsi audit internal di Baitul Mal Wa Tamwil (BMT) Karisma, Magelang. Terlibatnya sifat religiusitas pada sumber daya manusia di lembaga keuangan syariah, dan adanya batasan waktu yang berlaku dapat mempengaruhi efektivitas fungsi audit.  Penelitian ini menggunakan metode kualitatif dengan menggunakan teknik wawancara untuk pengumpulan data. Narasumber dalam penelitian ini adalah 2 orang auditor internal yang telah menjalani profesi audit internal di BMT Karisma, Magelang. Hasil penelitian ini menunjukkan Religiusitas individu akan meningkatkan integritas dan independensi auditor yang kemudian dapat mencapai keefektifan fungsi audit internal. Adanya religiusitas di setiap individu akan mewujudkan kinerja yang penuh kehati – hatian, ketelitian, ketekunan dan terhindar dari kecurangan. Dengan terwujudnya efektivitas fungsi audit internal melalui faktor religiusitas akan menghasilkan laporan audit yang berkualitas dan dapat dipercaya, serta menjadi langkah untuk memajukan lembaga keuangan syariah. Batasan waktu sejalan dengan tingkat efektivitas fungsi audit internal. Auditor perlu menjalankan manajemen waktu di atas batasan waktu yang telah ditentukan. Sehingga, auditor dapat menuntaskan tugasnya, dan memenuhi fungsi auditor secara efektif. Kata kunci: Religiusitas, Batasan Waktu Audit, Efektivitas Fungsi Audit
The Feasibility and Utility of a Personal Health Record for Persons With Dementia and Their Family Caregivers for Web-Based Care Coordination: Mixed Methods Study
Authors: Peterson Colleen M , Mikal Jude P , McCarron Hayley R , Finlay Jessica M , Mitchell Lauren L , Gaugler Joseph E
Published: May 2020

Background

Managing the complex and long-term care needs of persons living with Alzheimer disease and related dementias (ADRD) can adversely impact the health of informal caregivers and their care recipients. Web-based personal health records (PHRs) are one way to potentially alleviate a caregiver’s burden by simplifying ADRD health care management

Objective

This study aimed to evaluate Personal Health Record for Persons with Dementia and Their Family Caregivers (PHR-ADRD), a free web-based information exchange tool, using a multiphase mixed methods approach.

Methods

Dementia caregivers (N=34) were surveyed for their well-being and perceptions of PHR-ADRD feasibility and utility at 6 and 12 months using close- and open-ended questions as well as a semistructured interview (n=8). Exploratory analyses compared participants’ characteristics as well as PHR-ADRD use and experiences based on overall favorability status.

Results

Feasibility and utility scores decreased over time, but a subset of participants indicated that the system was helpful. Quantitative comparisons could not explain why some participants indicated favorable, neutral, or unfavorable views of the system overall or had not engaged with PHR-ADRD. Qualitative findings suggested that technology literacy and primary care provider buy-in were barriers. Both qualitative and qualitative findings indicated that time constraints to learn and use the system affected most participants.

Conclusions

Development and dissemination of PHRs for family caregivers of persons with ADRD should aim to make systems user-friendly for persons with limited time and technological literacy. Establishing health care provider buy-in may be essential to the future success of any PHR system.
Mobile Health Usage, Preferences, Barriers, and eHealth Literacy in Rheumatology: Patient Survey Study (Preprint)
Authors: Knitza Johannes , Simon David , Lambrecht Antonia , Raab Christina , Tascilar Koray , Hagen Melanie , Kleyer Arnd , Bayat Sara , Derungs Adrian , Amft Oliver , Schett Georg , Hueber Axel J
Published: May 2020

BACKGROUND

Mobile health (mHealth) defines the support and practice of health care using mobile devices and promises to improve the current treatment situation of patients with chronic diseases. Little is known about mHealth usage and digital preferences of patients with chronic rheumatic diseases.

OBJECTIVE

The aim of the study was to explore mHealth usage, preferences, barriers, and eHealth literacy reported by German patients with rheumatic diseases.

METHODS

Between December 2018 and January 2019, patients (recruited consecutively) with rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis were asked to complete a paper-based survey. The survey included questions on sociodemographics, health characteristics, mHealth usage, eHealth literacy using eHealth Literacy Scale (eHEALS), and communication and information preferences.

RESULTS

Of the patients (N=193) who completed the survey, 176 patients (91.2%) regularly used a smartphone, and 89 patients (46.1%) regularly used social media. Patients (132/193, 68.4%) believed that using medical apps could be beneficial for their own health. Out of 193 patients, only 8 (4.1%) were currently using medical apps, and only 22 patients (11.4%) stated that they knew useful rheumatology websites/mobile apps. Nearly all patients (188/193, 97.4%) would agree to share their mobile app data for research purposes. Out of 193 patients, 129 (66.8%) would regularly enter data using an app, and 146 patients (75.6%) would welcome official mobile app recommendations from the national rheumatology society. The preferred duration for data entry was not more than 15 minutes (110/193, 57.0%), and the preferred frequency was weekly (59/193, 30.6%). Medication information was the most desired app feature (150/193, 77.7%). Internet was the most frequently utilized source of information (144/193, 74.6%). The mean eHealth literacy was low (26.3/40) and was positively correlated with younger age, app use, belief in benefit of using medical apps, and current internet use to obtain health information.

CONCLUSIONS

Patients with rheumatic diseases are very eager to use mHealth technologies to better understand their chronic diseases. This open-mindedness is counterbalanced by low mHealth usage and competency. Personalized mHealth solutions and clear implementation recommendations are needed to realize the full potential of mHealth in rheumatology.
Differential Diagnosis of COVID-19 and Influenza: a Web-Based Predictive Tool Designed with Available Data from China and the U.S. (Preprint)
Authors: Alemi Farrokh , Vang Jee , Guralnik Elina , Roess Amira
Published: May 2020

BACKGROUND

Limited guidance is available on how community-based health care providers can diagnose COVID-19 or how employers can monitor employees’ symptoms upon return to work following shelter-in-place or other state-enforced orders.

OBJECTIVE

This analysis provides a method of assessing risk of COVID-19 in the community as opposed to hospital settings.

METHODS

Published data shows how asymptomatic COVID-19 patients can be diagnosed based on demographic (age, race, and gender), clinical (i.e. anosmia, blood oxygen levels), and exposure (i.e. close contact in health care setting, use of public transportation, recent travel, social distancing practices) data. For symptomatic patients we contrast symptoms of COVID-19 patients (709 Chinese and 272 United States) patients against 2,885 United States influenza and 884 other influenza-like illnesses patients. Two models were developed for diagnosing COVID-19 in the community-based settings: 1) during flu season and 2) after flu season. Accuracy of the predictions was calculated using the micro average, and the sample weighted micro average, Area under the Receiver Operating Characteristic (AROC) curves.

RESULTS

Fever and cough were the two most common COVID-19 symptoms. If clinicians use these two symptoms, they would make numerous errors (AROC=0.49). They would correctly diagnose 48% of COVID-19 patients, and correct ruling out of 68% of non-COVID-19 patients. In contrast to the simplified rules, using all patients’ symptoms (not just fever and cough) correctly diagnosed COVID-19 with AROC of 0.79.

CONCLUSIONS

Community-based health care providers and large employers screening employees returning to work need continuously updated tools that adjust for flu season and the diagnostic value of known signs and symptoms of COVID-19. Simplified rules do not work. Diagnosing COVID-19 in the community settings requires probabilistic inferences that are beyond human capabilities. To assist in the rapid diagnoses, we developed a free web calculator: http://hi.gmu.edu/c19
The Challenges Confronting Countries in the Tropics Affected by Covid-19
Authors: Kakonge Amb. Dr. John O.
Published: May 2020

Compared with other regions of the world, countries in the Tropics appear to have less Covid-19 cases and lower death rates. Warmer temperatures and higher humidity have been proposed as an explanation. An alternative interpretation is that the figures result from a lack of aggressive testing. Regardless of the cause, this paper suggests that the way in which governments respond to the pandemic has a significant impact on containing the pandemic. Additionally, pressing challenges for countries in the Tropics are a lack of water and sanitation, insufficient personal protective equipment, and inadequate training of clinical staff. Suggestions for moving forward are proposed.
STUDENTS’ ABILITY TO READ STATISTICAL DIAGRAM
Authors: Sutiarso Sugeng
Published: May 2020

Reading diagrams is an important ability needed by college students, particularly to writing their thesis. This ability could help students in describing and communicating the results of their research. Conversely, the inability to read diagrams causes errors in interpreting the results of the research. This descriptive qualitative study aims to describe the ability of students to read diagrams in terms of gender differences and the tendency to choose problems between bar/line diagrams, and the reasons behind the difficulties for students reading diagrams. This study involved 25 students of Mathematics Education, University of Lampung. Research data were collected using test and interview instrument. The results showed that students’ability both male and female to read diagrams was classified as moderate, the ability to read bar charts of female students was higher than that of male students but the ability to read line diagrams of male students was higher than female students, female students tend to choose bar diagrams rather than line diagrams while male students tend to choose line diagrams rather than bar diagrams, and the cause of difficulties in reading diagrams for female students were errors in understanding the meaning words while male students were errors of logical thinking in associating data with other data.
EDUCATORS’ PERCEPTION OF BLENDED LEARNING MODELS ON MATHEMATICS LEARNING
Authors: Faradillah Ayu , Hadi Windia
Published: May 2020

The main objective of this research is to analyze and compare educators' perceptions of the application of the BL model in mathematics learning. The stages of research carried out in this study began with the manufacture of questionnaires both for educators and students. Next the researchers asked one of the lecturers and mathematics teachers to validate it. Based on the results of the validation conducted, the questionnaire was declared to be appropriate to be used by correcting a selection of words so it would not have a double meaning. In the next stage, researchers distributed the questionnaire to educators in schools and universities in several provincies in Indonesia After obtaining the data, researchers analyzed the data using WinStep. The results of the questionnaire showed that there was one question on the questionnaire that was difficult to be agreed upon by lecturers and teachers, namely the 16th statement that revealed students felt they needed more time to complete online assignments when dealing with graphics / diagrams / tables / other on mathematical material
Review of Cervical Cancer Preventive and Screening Strategies in India
Authors: Meena Devi , Chand Subhash , Kumar Deovrat
Published: May 2020

Cervical cancer (CC) rapidly spread in the women. CC is the cancer which start from the cervix this is the 1st stage and 3rd most common type cancer in women’s worldwide. Continuously, Human papillomavirus (HPV) infection is the higher&strongest epidemiologic risk factor for CC.HPV-16 and HPV-18, these are type virus with high-risk HPV types. But at present many types of techniques available as – Pap smear test, Colposcopy, HPV virus test/detection, Visual inspection of cervix with 5% acetic acid, and Visual inspection of cervix with Lugol’s Iodine.The majority of diagnosis with CC will be analyzed more than 13000 and rate of death 4000 with women in United States and it also deadline disease in India. It is one of the cancer which is preventable. This article studied with in PubMed and Google scholar, studies about cervical cancer from Wikipedia and you-tube also. And it is only meta-analysis or multi-institutional, review article and research studies were considered for analysis of cervical cancer. The most important risk factor is determined with human beings Human papillomavirus (HPV) which traditional in worldwide. This is the type of cancer which is screening and detect in the early stage by the screening methods. In this article, abstracted published studies about to year between during 1995-2018 which has been carried out in worldwide on CC with significance on screening test methods.  Basically, Pap smear is the method of screening for cytology but now a day many studies have been accomplish to investigate different methods as well as visual inspection method.

Keywords: Cervical Cancer screening, HPV, Screening methods, Pap Smear test, India United State.
An Advanced Review on Resealed Erythrocytes
Authors: Begum Gousia S. , D Mustafa
Published: May 2020

Now a days there are numerous applications have been proposed for the use of resealed erythrocytes as carrier for drugs, enzyme replacement therapy etc. Until other carrier systems come of age, resealed erythrocytes technology will remain an active field for the further research. The use of resealed erythrocytes shows potential for a safe and effective delivery of various bioactive molecules for effective targeting. In coming future, erythrocyte based drug delivery system with their capability to afford controlled and site specific drug delivery have been developed for disease management. Erythrocyte carriers are “Nano devices in the field of Nanotechnology”. A large amount of valuable work is needed so as to utilize the potentials of erythrocytes in passive as well as active targeting of drugs in diseases like cancer. At present erythrocytes are most effective carriers in novel drug delivery systems considering their tremendous potential. Hence the present article is reviewed about method of drug loading, evaluation and applications of RSE.
Lead Exposure Causes Alteration of Haematological Indices in Adult Female Wistar Rats
Authors: I Adeyomoye O , A Adewumi N
Published: May 2020

Objective: Lead is a heavy metal widely distributed in the environment. It is known to be a toxicant and has no biological function. Humans are constantly exposed to lead from many sources and its effects on the haematological indices have not been fully elucidated. Therefore, this study aimed to investigate the changes in haematological profile of adult female Wistar rats exposed to lead.

Design: Forty-five female Wistar rats with average weight of 150 ± 20g were randomly distributed into 3 groups of 15 rats each. Group 1 served as the control and was exposed to water only, group 2 was exposed to lead acetate (500mg/L) while group 3 was exposed to lead acetate (1000mg/L). The rats were exposed to lead for 52 days. On the 26th, 39th and 52nd days of exposure, five rats (n=5) were sacrificed from each group after mild anaesthesia and their blood samples were taken into EDTA bottles for haematological analysis using blood auto-analyzer. Results were analyzed using two-way ANOVA and p<0.05 were considered statistically significant.

Main outcome measure: There was significant increase (p<0.05) in white blood cell and lymphocyte counts in 500mg/L and 1000mg/L lead exposed groups when compared to the control. There was significant decrease (p<0.05) in monocyte and granulocyte counts in 500mg/L and 1000mg/L lead exposed groups when compared to control group. Platelet counts significantly increased (p<0.05) in 500mg/L and 1000mg/L lead exposed groups when compared to control group.

Conclusion: In conclusion, exposure to lead at 500 and 1000mg/L increased white blood cells, lymphocyte and platelet counts while it decreased monocyte and granulocyte counts in adult female Wistar rats. Therefore, lead at the exposed levels caused some alterations in the haematological parametersin adult female Wistar rats.
Quality Assessment of Antibiotic Oral Drug Formulations Marketed In Katsina State, Nigeria
Authors: Lawal Mukhtar Gambo , Mukhtar Muhammad Dauda , Magashi Abdulkadir Magaji
Published: May 2020

There are increasing reports on the high incidence of substandard drugs, especially in developing countries.Pharmaceutical products have been reported to contain either no, low, or excessive amounts of the active pharmaceutical ingredient (API). Inview of the above, 112 samples of six different antibiotic oral drug formulations were evaluated for chemical quality by assessing the presence and the percentage content of the stated active pharmaceutical ingredients using validated HPLC assay as described in the official monograph of the British and United Stated pharmacopoeia. The result indicates that 43 (38.4%) had active ingredients outside the set pharmacopoeial limit and therefore were non-compliant to the BP and the USP specifications for percentage content.  Ampiclox and Cotrimoxazole had the highest proportion of samples with active ingredient outside the pharmacopoeial limit, and in three samples (one Augmentin and two Ampiclox), no active ingredient was detected. The presence of API lower than the claimed content declared on the packaging was the primary cause of non-compliance. The potential implications of the use of substandard drugs are treatment failure and the development of drug-resistance.
Absence of Renal Protection of an Aqueous Extract of Lemongrass (Cymbopogon citratus) Cultivated in Costa Rica, Using a Model of Acute Renal Failure in Wistar Rats
Authors: Navilla Apú Leitón , Manuel Fallas Ramírez Jose , Josué Orozco Aguilar , Alexander Rodríguez Arrieta Jesús , José Mora Román Juan
Published: May 2020

citratus, known as zacate de limón (lemongrass), is commonly used in Costa Rica for the treatment of "kidney diseases." Therefore, the activity as renal protector of an aqueous extract of this plant was evaluated after oral administration, in a model of acute kidney injury (AKI) in female Wistar rats. For this, an aqueous extract was characterized by thin layer chromatography and qualitative phytochemical tests. An AKI model induced by potassium chromate in female Wistar rats was carried out. The serum concentration of creatinine, sodium, potassium and glucose were determined, as well as the concentrations of creatinine, sodium, potassium, glucose and proteins in urine, together with the urinary flow determination. A histopathological analysis of the subjects’ kidneys was performed, and the presence of kidney damage was identified. The characterization of the extract by thin layer chromatography, and ferric chloride, Shinoda and Wilson tests gave negative results for phenols, tannins and flavonoids. No positive changes were observed in renal function markers in urine. No histopathological evidence of nephroprotective activity of the aqueous extract of C. citratus was found. It is concluded that the aqueous extract of C. citratus obtained by infusion does not possess nephroprotective activity at a dose of 150 mg/kg evaluated by the AKI in female Wistar rats.
Antiinflammatory Activity of Pagoda Flower (Clerodendrum Paniculatum L.) Ethanol Extract Using Paw Edema Method
Authors: Hafiz Ihsanul , Ginting Mandike
Published: May 2020

Objectives: The purpose of this study was to determine antiinflammatory activity of pagoda flower (Clerodendrum paniculatum L.) ethanolic extract

Design: This study uses an experimental laboratory design. This research uses paw edema method by inducing carrageenin in the legs of male white rats as an induction of inflammation.

Interventions: The sample used was pagoda flower ethanol extract in various dosages of 25, 50 and 100 mg / kg. As a comparison, acetosal dose 33 mg / kg was used. Na CMC suspension was used as a negative control.

Main outcome measure: The results in this study are the difference in the volume of edema volume from rat feet per unit time. The measurement of the rat's leg volume was measured at 30, 60, 120, 180, 240 and 300 minutes.

Conclusion: Pagoda flower ethanol extract does not have good anti-inflammatory activity. there were no significant differences between groups except at dose 100 and positive control at minute 300 of negative control.