bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis, Structural, Optical and Optoelectrical Properties of the Chemically Deposited Cu2BaGeS4 Thin Films
Authors: Alsulami Abdullah , Alsalme Ali
Published: December 2023

In this work, thin films of copper barium germanium sulfide (Cu2BaGeS4) were generated via the chemical bath deposition technique. The X-ray diffractometer identified the Cu2BaGeS4 layers’ crystal structure. It showed that the Cu2BaGeS4 films have a hexagonal structure. The EDAX results demonstrated stoichiometric composition, which validated the composition of the Cu2BaGeS4 layers. However, the Cu2BaGeS4 sheets under investigation showed a direct energy gap, as demonstrated by the linear optical analysis, with the E

g
falling from 1.61 to 1.42 eV as the sample thickness rose from 239 to 463 nm. As the film thickness increased, the refractive index and Urbach energy values improved as well. Additionally, the examined Cu2BaGeS4 sheets’ optoelectrical indices, including optical dielectric constants, electrical conductivity, optical mobility, and optical conductivity, improved with thickness. This work shows that increasing the layer thickness enhanced the magnitudes of the nonlinear optical index of the novel Cu2BaGeS4 sheets. Cu2BaGeS4 layers tended to acquire p-type properties, as demonstrated by the hot probe test.
Enteric glial cell network function is required for epithelial barrier restitution following intestinal ischemic injury in the early postnatal period
Authors: Ziegler Amanda L. , Caldwell Madison L. , Craig Sara E. , Hellstrom Emily A. , Sheridan Anastasia E. , Touvron Melissa S. , Pridgen Tiffany A. , Magness Scott T. , Odle Jack , Van Landeghem Laurianne , Blikslager Anthony T.
Published: December 2023

This study refines a powerful translational pig model, defining an age-dependent relationship between enteric glia and the intestinal epithelium during intestinal ischemic injury and confirming an important role for enteric glial cell (EGC) activity in driving mucosal barrier restitution. This study suggests that targeting the enteric glial network could lead to novel interventions to improve recovery from intestinal injury in neonatal patients.
Real‐Time Frequency Adaptive Tracking Control of the WPT System Based on Apparent Power Detection
Authors: Feng Hongwei , Liu Yuanyuan , Huang Conggui , Xie Linbo , Qi Bin
Published: December 2023

In wireless power transfer (WPT) systems, inverters are used to achieve high‐frequency conversion of DC/AC, and their conversion efficiency and working frequency are key factors affecting the system’s power transfer efficiency. In practical applications, many hardware issues, such as power transistor shutdown and loss, are the main reasons that affect the inverter conversion efficiency. On the other hand, the working frequency of WPT systems ranges from hundreds of kHz to a few MHz, and traditional voltage and current phasor estimation requires a very high sampling rate which is difficult to achieve. To overcome these limitations, this paper introduces a phase‐shifting full bridge inverter using a zero‐voltage switching (ZVS) soft switching technology to optimize the conversion efficiency of the inverter. Meanwhile, apparent power is introduced to detect the operating frequency and phase angle. Combined with an FPGA soft switching control strategy, this approach allows for the quick adjustment of the driving pulse of MOS transistors, as well as the voltage and current at the transmitting end, to a completely symmetrical state in real‐time, effectively suppressing frequency offset and achieving efficient frequency tracking control and maximum efficiency tracking (MET) control of the WPT system. Through simulation and experiments, the ZVS soft switching technology has been achieved with the inverter control strategy, leading to improved conversion efficiency. The frequency offset that can be corrected can reach 0.1 Hz using the apparent power detection method, and the maximum transfer efficiency of the WPT system can reach 91%.
Solidifying Fenofibrate Nanocrystal Suspension: A Scalable Approach via Granulation Method
Authors: Tran Bao Ngoc , Tran Hiep Tuan , Le Giang Thi , Tran Ha Phuong , Le Khanh Ngoc , Do Huy Hoang , Dao Anh Hoang , Nguyen Chien Ngoc
Published: December 2023

The pharmaceutical industry has highlighted particle-size reduction via preparing aqueous suspensions containing nano- or submicron drug particles. Owing to the risk of agglomeration and complications during the manufacturing of solid dosage forms, the problems associated with the solidification of nanosuspensions need to be addressed. Herein, the nanocrystallized suspension of fenofibrate (Feno) was prepared using the wet-milling technique, and then two solidification methods, mixing (liquid mixing) and granulation (dry powder blending and wet massing) methods, were investigated. The solidification process involved the adsorption of Feno as a very thin layer on the high-surface-area Florite® to prevent drug accumulation. The critical quality attributes, particle size and dissolution rate, were performed. Infrared spectroscopy, X-ray diffraction, differential scanning calorimetry, and scanning electron microscopy were also used to monitor the existence and physical state of drug molecules in the carrier. The final solidified powders and tablets containing Feno nanocrystals improved the dissolution profile (>90% in 15 min), in which the physical properties of Feno were maintained during solidification and tableting. In general, the granulation method is more advantageous than the mixing method in terms of maintaining amorphous proportion and dissolution rate. These results implied a potential approach for manufacturing solid dosage forms from nanoscale products.
Well-Posedness in Variable-Exponent Function Spaces for the Three-Dimensional Micropolar Fluid Equations
Authors: Abidin Muhammad Zainul , Marwan Muhammad , Ullah Naeem , Mohamed Zidan Ahmed
Published: December 2023

In this paper, we work on the Cauchy problem of the three-dimensional micropolar fluid equations. For small initial data, in the variable-exponent Fourier–Besov spaces, we achieve the global well-posedness result. The Littlewood–Paley decomposition method and the Fourier-localization technique are main tools to obtain the results. Moreover, the results discussed in our work show the Gevrey class regularity of solution to the Cauchy problem of micropolar fluid equations.
Spontaneous Extensive Type A Aortic Dissection in an Older Female with No Risk Factors: A Rare Clinical Presentation
Authors: Lathiya Maulik K. , Cullinan Susan M.
Published: December 2023

Background. Aortic dissection (AD) is a rare but serious medical emergency where the aorta’s inner layer tears. Females are less likely to develop it than males, and AD cases with unusual symptoms can be hard to diagnose. Diagnosing AD can be further complicated as its symptoms and electrocardiogram (ECG) changes can mimic acute coronary syndrome, and it is challenging to distinguish it without risk factors. Case Report. This case report describes a 60-year-old female patient who presented with unusual symptoms, including pain in her chest, neck, left arm, and lower extremities. An electrocardiogram (ECG) revealed ST elevation in leads aVR and V1, as well as severe ST depression and T wave inversion in the inferior and lateral leads, which can mimic acute coronary syndrome. Despite initial treatment with nitroglycerin, the patient’s pain worsened, and a CT angiography revealed type A aortic dissection extending from the aortic root to the right external iliac artery. Immediate surgery was recommended, which significantly improved the patient’s condition. Conclusions. Be aware of aortic dissection and its symptoms, even if there are no risk factors or recognizable symptoms. Consider aortic dissection as a potential diagnosis if ECG changes are present. Ongoing education can help decrease mortality and increase awareness.
Seed Germination Enhancement of Two Balanites Species (B. aegyptiaca (L.) Del. and B. rotundifolia (Tiegh.) Blatt.) Using Different Presowing Treatments in Ethiopia
Authors: Seid Mohammed Adefa , Wondimu Tigist , Degu Asfaw , Assefa Awol
Published: December 2023

B. aegyptiaca and B. rotundifolia are known to be multipurpose trees with various uses and values. Therefore, the aim of this study was to investigate the seed germination behaviours of B. aegyptiaca and B. rotundifolia under different presowing treatments. Hence, seeds were collected from the Central and Southern Ethiopian Rift Valley regions. Then, a total of 864 fruits (seeds) subjected to eight different presowing treatments and planted in pots arranged in a completely randomized design (CRD) were tested for each species. The mean germination percentage (GP), mean daily germination percentage (GD), mean germination time (GT), and mean germination index (GI) were computed. One-way ANOVA showed the presence of significant GP, GD, GT, and GI among treatment groups at p<0.05 under both Balanites species. For B. aegyptiaca, Tukey’s HSD test showed that seeds soaked with 98% H2SO4 for 10 minutes (98HSO10m) and 20 minutes (98HSO20m) have the highest GPs (87 ± 8.8 and 82 ± 10.2, respectively) that are significant at p<0.05. The seeds soaked in 75°C hot water for 10 minutes and subsequently cooled for 12 hours (HW75d), 98HSO10m, and 98HSO20m have the highest GDs (2%) that are significant at p<0.05. Moreover, 98HSO20m, 98HSO10m, and seeds soaked in cold water for 48 hours at room temperature of 25°C (CW48h) have the shortest GTs (24 ± 2.2, 25 ± 0.5, and 25 ± 1.3, respectively), and 98HSO10m and 98HSO20m have the highest GIs (1.04 ± 0.09 and 1.01 ± 0.08, respectively) that are significant at p<0.05. For B. rotundifolia, the control recorded the highest cumulative germination (i.e., 71), followed by CW48h (i.e., 51). However, Tukey’s HSD tests generally indicated that no treatment group resulted in significant differences in the means of GP, GD, GT, and GI at p<0.05. So, no treatment group was observed to enhance the germination of B. rotundifolia compared to the control. However, this study generally indicated potential seed enhancement technologies for B. aegyptiaca with greater implications for propagation, conservation, and sustainable utilization of the species in the agricultural and pastoral communities of Ethiopia.
Compendium of Clinical Variant Classification for 2,246 Unique ABCA4 Variants to Clarify Variant Pathogenicity in Stargardt Disease Using a Modified ACMG/AMP Framework
Authors: Cornelis Stéphanie S. , Bauwens Miriam , Haer-Wigman Lonneke , De Bruyne Marieke , Pantrangi Madhulatha , De Baere Elfride , Hufnagel Robert B. , Dhaenens Claire-Marie , Cremers Frans P. M.
Published: December 2023

Biallelic variants in ABCA4 cause Stargardt disease (STGD1), the most frequent heritable macular disease. Determination of the pathogenicity of variants in ABCA4 proves to be difficult due to (1) the high number of benign and pathogenic variants in the gene; (2) the presence of many rare ABCA4 variants; (3) the presence of complex alleles for which phasing data are absent; (4) the extensive variable expressivity of this disease and (5) reduced penetrance of hypomorphic variants. Therefore, the classification of many variants in ABCA4 is currently of uncertain significance. Here, we complemented the ABCA4 Leiden Open Variation Database (LOVD) with data from ~11,000 probands with ABCA4-associated inherited retinal diseases from literature up to the end of 2020. We carefully adapted the ACMG/AMP classifications to ABCA4 incorporating ClinGen recommendations and assigned these classifications to all 2,246 unique variants from the ABCA4 LOVD to increase the knowledge of pathogenicity. In total, 1,248 variants were categorized with a likely pathogenic or pathogenic classification, whereas 194 variants were categorized with a likely benign or benign classification. This uniform and improved structured reclassification, incorporating the largest dataset of ABCA4-associated retinopathy cases so far, will improve both the diagnosis as well as genetic counselling for individuals with ABCA4-associated retinopathy.
Land Use and Land Cover Dynamics: Deriving Forces and Perceptions of Local Community in Derashe, Southern Ethiopia
Authors: Taye Agegnehu , Anbacha Abiyot , Girma Firehiywet
Published: December 2023

Changes in land use and land cover (LULC) reached a point where we must reconcile. Thus, this study was conducted to assess the LULC changes, deriving forces, and the local community perceptions in Derashe, Southern Ethiopia. Landsat Series sensors’ 4, 5, and 8 imagery was used to analyze the LULC over the year. Focus group discussions (FGDs) and key informant interviews (KIIs) were used to assess the deriving force and perceptions. Maximum likelihood of the supervised digital image classification technique was employed. Postclassification was used to detect and quantify changes. Deriving force and perception data were analyzed through descriptive statistics and narration. Five major LULC classes were identified. A major increase was observed in settlement and agricultural land by displacing forest and bush lands. However, the water body was fluctuated. According to the local community, the agricultural land expansion and growing population pressure are the major proximate and underlying deriving forces, respectively. Therefore, proper design for efficient use is necessary.
MPO Expression of Background Neutrophils in MPO Negative Acute Promyelocytic Leukemia, An Easy Clue to Corroborate a Challenging Diagnosis: A Case Report and Review of Literature
Authors: Krishnamurthy Kritika , Choudhuri Jui , Ramesh K. H. , Wang Yanhua
Published: December 2023

Acute promyelocytic leukemia (APL) is characterized by the pathogenic driver fusion transcript PML-RARA resulting from the t(15;17) translocation. Early recognition of APL with prompt ATRA induction has a decisive impact on the early death rate. The preliminary diagnosis of APL relies heavily on cytomorphology and flow cytometry. In APL with variant morphology, such as the microgranular variant, immunophenotype, especially the bright MPO positivity is the basis of diagnosis. Till date, only five cases of APL with reduced/absent MPO have been described in literature. The identification of MPO deficiency based on genetic testing would involve at the least a MPO gene scanning with NGS, followed by microarray to identify somatic uniparental disomy in heterozygotes. This testing is not only redundant given the scant clinical implications of heterozygous MPO deficiency but also time consuming. An easy way to identify background MPO deficiency confounding the immunophenotype of a myeloid neoplasm is the MPO expression in background neutrophils gated on the initial flow cytometry. A dim MPO in the background neutrophils, in the morphological setting of APL, can identify underlying MPO deficiency, clarifying the immunophenotypic ambiguity and thus establishing an unequivocal diagnosis as seen in the current case.
Adipose Tissue-Derived Extracellular Vesicles: A Promising Biomarker and Therapeutic Strategy for Metabolic Disorders
Authors: Liu Wenhui , Liu Tianyan , Zhao Qingyu , Ma Junqiu , Jiang Jiajia , Shi Hui
Published: December 2023

Adipose tissue plays an important role in systemic energy metabolism, and its dysfunction can lead to severe metabolic disorders. Various cells in adipose tissue communicate with each other to maintain metabolic homeostasis. Extracellular vesicles (EVs) are recognized as novel medium for remote intercellular communication by transferring various bioactive molecules from parental cells to distant target cells. Increasing evidence suggests that the endocrine functions of adipose tissue and even the metabolic homeostasis are largely affected by different cell-derived EVs, such as insulin signaling, lipolysis, and metabolically triggered inflammation regulations. Here, we provide an overview focused on the role of EVs released by different cell types of adipose tissue in metabolic diseases and their possible molecular mechanisms and highlight the potential applications of EVs as biomarkers and therapeutic targets. Moreover, the current EVs-based therapeutic strategies have also been discussed. This trial is registered with NCT05475418.
Differential Regulation of the STING Pathway in Human Papillomavirus–Positive and -Negative Head and Neck Cancers
Authors: Saulters Emma L. , Kennedy Paul T. , Carter Rachel J. , Alsufyani Abdullah , Jones Terence M. , Woolley John F. , Dahal Lekh N.
Published: December 2023

Squamous cell carcinomas, which arise from the cells that line the mucosal surfaces of the head and neck, represent the most common type of head and neck cancers (HNSCC). Human papillomavirus (HPV) infection has been strongly associated with the development of oropharyngeal cancers, which are cancers that occur in the back of the throat, including the tonsils and base of the tongue. HNSCCs with and without HPV infection have distinct pathology, with HPV-positive patients having higher levels of immune infiltration, activation in the tumor microenvironment and better response to radiation and chemotherapy. It is, however, unclear whether HPV infection in HNSCCs has the potential to activate innate-immune sensing pathways and if these cancers possess intrinsic immunogenicity associated with HPV infection. Here we investigate the innate immune stimulator of interferon genes (STING) pathway and immune responses to STING activation in HNSCCs and uncover fundamental differences in the regulation of this pathway in cell lines versus primary human clinical specimens. We show that while STING is differentially expressed in HPV-positive and -negative HNSCC cell lines, they exhibit a gross functional defect in signaling through this pathway. However, STING activation in immune cell populations generated immune signatures predicted to elicit useful tumoricidal mechanisms. In contrast, IHC analysis of human tissue microarrays revealed enhanced STING expression in HPV-related tumors and high intratumoral expression of STING correlated with increased survival.

Significance:

STING is an important innate immune sensor of cytosolic DNA, inducing essential antiviral and antitumoral responses. This research shows that STING expression is enhanced in HPV-positive HNSCC patient tissue, with high intratumoral STING expression correlating with increased survival. In addition, STING activation in immune cell populations augmented antitumoral effects against HNSCCs, suggesting patients may benefit from the use of STING agonists in combination with traditional therapies.
Dapagliflozin Ameliorates Ovulation Disorders via Attenuating Activated Microglia-Mediated Hypothalamic Inflammation in HFD-Fed Mice
Authors: Chen Xiaolin , Xiao Zhuoni , Liu Qing , Luo Deng , Cai Yuli , Fan Mingxia
Published: December 2023

Introduction: Sodium-glucose cotransporter 2 inhibitors (SGLT2is) have shown neuroprotective effects in obese mice. However, whether SGLT2i can ameliorate high-fat diet (HFD)-related ovulation disorders remains unknown. The aim of this research was to investigate whether dapagliflozin improves HFD-induced ovulatory dysfunction by attenuating microglia-mediated hypothalamic inflammation. Methods: C57BL/6J female mice fed HFD were treated with dapagliflozin (1 mg/kg) for 22 weeks. Plasma insulin, leptin, luteinizing hormone (LH), estradiol (E2), and IL-1β levels were also tested. Microglial morphology, cell numbers, and SGLT2 expression were evaluated using immunofluorescence. The expression of IL-1β, NLRP3, kisspeptin, gonadotropin-releasing hormone (GnRH), SGLT2, insulin, and leptin receptors in the hypothalamus was determined using immunohistochemical staining. We also examined the effects of dapagliflozin on glucose metabolism and the release of inflammatory factor in palmitic acid (PA)-treated HMC3 cells. Results: As expected, dapagliflozin improved HFD-induced metabolic disturbances, peripheral versus central insulin and leptin resistance and also restored the regular estrous cycle. Furthermore, dapagliflozin blunted microglia activation, NLRP3 inflammasome priming, hypothalamic inflammation, and increased the expression of GnRH and kisspeptin at proestrus in the hypothalamus. Additionally, dapagliflozin markedly reduced IL-6 and NO release and fat accumulation, decreased lactic acid production and glucose consumption, and inhibited mammalian target of rapamycin (mTOR) and hexokinase 2 (HK2) expression in PA-treated HMC3 cells. These effects suggest that dapagliflozin reduced the mTOR/HK2-mediated aerobic glycolysis. Conclusions: Dapagliflozin improved HFD-related ovulation disorders by regulating glucose metabolism through mTOR/HK2 signaling and attenuating microglia-mediated hypothalamic inflammation. These results validate the novel role for the neuroprotection of SGLT2i in HFD-induced obesity and ovulation disorders.
Report of new myristica swamp ecosystems from the Western Ghats at Pathanapuram, Kerala, India
Authors: Joseph Niji , R. Sreejai  , M. Ajayakumar
Published: December 2023

We present a new distributional report of myristica swamp ecosystems in the Western Ghats at Pathanapuram, Kerala, India based on several distinct field surveys from April 2022 to June 2022. From Kerala, myristica swamp has previously been reported mainly from Shendurney Wildlife Sanctuary, Kulathupuzha Reserve Forests, and adjoining regions of the Anchal forest ranges in southern Western Ghats. The present study described and illustrated the occurrence of myristica swamp from the Pathanapuram forest range in Kerala for the first time. The observed myristica swamps from the Pathanapuram forest range are seen inside the Ambanar model forest station and Punnala forest station limits. A total of 18 myristica swamp patches from Ambanar and seven myristica swamps from Punnala were reported and captured. A pilot survey from these sites suggests they are abundant with various faunal and floral wealth. Therefore, recognition and conservation of these ecosystems are essential and vital and suggest further surveys and conservation efforts.
Recent record of Eurasian Otter Lutra lutra (Linnaeus, 1758) (Mammalia: Carnivora: Mustellidae) from Kerala part of the Western Ghats, India and an insight into the behaviour and habitat preferences
Authors: Mohan Sreehari K. , Lathish R. Nath  , K.S. Subin  , Sreekumar K. Govindankutty  , P.O. Nameer
Published: December 2023

We report a recent record of the elusive Eurasian Otter Lutra lutra from Kerala, through a direct observation in the higher reaches of the Chinnar Wildlife Sanctuary within the Western Ghats, southern India. Field observation involved the sighting of two Eurasian Otters in a rocky-torrential stream in March 2020. The otters displayed a hyperactive foraging behaviour, searching among submerged rocks and crevices, followed by occasional dives. They seemed particularly interested in areas where water rushed with force, avoiding locations with low water flow or shallow pools. The observation site, at 1,275 m altitude in Chinnar Wildlife Sanctuary, located in the Western Ghats of Kerala region, featured wet evergreen vegetation, transitional sholas (stunted evergreen forests), and riparian patches along a stream characterised by rapid water flow, boulders, and fallen trees. This habitat, as observed by others, was also indicative of Asian Small-clawed Otter Aonyx cinereus suitability, suggesting potential resource partitioning between the two otter species. This discovery challenges previous assumptions about the preferred habitat of Eurasian Otters in the Western Ghats and emphasizes the need for comprehensive research on the taxonomy, distribution, population status, and behaviour of these possibly sympatric species of otters, the Asian Small-clawed Otter and the Eurasian Otter. Such studies are crucial for the conservation of both these species, which face threats from habitat loss, sand mining, hunting, and population decline. Preserving and restoring riparian vegetation in the higher reaches of the Western Ghats is essential for their protection within this biodiversity hotspot.
First confirmed record of Arabian Gazelle Gazella arabica Lichtenstein, 1827 (Mammalia: Artiodactyla: Bovidae) on Masirah Island, off the coast of eastern Oman in the Arabian Sea
Authors: Al Said Taimur , Al Rawahi Haitham , Al Ansari Maha , Al Hinai Al Mutasim , Al Amri Ahmed , Al Wahaibi Ahmed , Al Farsi Ghasi , Al Wahibi Saud , Al Farsi Salman
Published: December 2023

In Oman, the Arabian Gazelle Gazella arabica is known to be distributed in the Hajar mountains of the north, desert plains in central of Oman, and Jabal Samhan foothills & Nejd area in the south. We report the first confirmed record of the Arabian Gazelle on Masirah island, 15 km off the mainland of eastern Oman. This finding was part of a national survey of biodiversity in Oman in which 29 camera traps were set to survey the majority of the island which covers about 400 km2. Only two camera traps detected Arabian Gazelle, in an area covering only 22 km2. The survey on the island suggests that the population is small and isolated. Future research studies are required both in the field of ecology and genetics.
Identifying potential habitats of Himalayan Red Panda Ailurus fulgens (Cuvier, 1825) (Mammalia: Carnivora: Ailuridae) in Neora Valley National Park, West Bengal, India
Authors: Bhutia Sangay W. , Giri Asim , Gupta Pranita , Holeyachi Basavaraj S.
Published: December 2023

The Himalayan Red Panda Ailurus fulgens (Cuvier, 1825) is a globally Endangered species whose population is reported to be declining in the wild. It is a priority species for the Neora Valley National Park (NVNP) since it is the flagship species of this ecosystem. Moreover, this landscape functions as an important connecting link of the Himalayan Red Panda habitat between the state of West Bengal and Sikkim. The spatial habitat of the Himalayan Red Panda in this National Park is little known. Our study attempts to identify the spatial distribution of potential habitats for the Himalayan Red Panda using the maximum entropy algorithm (MaxEnt 3.4.1). The model predicted a 55 km2 of potential habitat with the current climate scenario. With climate change, predicted potential habitats are likely to experience significant loss and upward shift to a relatively higher elevation. Hence, the management of the NVNP should identify the potential habitats and accomplish realistic goals to help conserve the Red Pandas.­­
Three new additions to the flora of Himachal Pradesh, India from Khokhan Wildlife Sanctuary, Kullu District
Authors: Sharma Ashutosh , S. Noorunnisa Begum  , G.S. Goraya  , Gopal S. Rawat  , Vaneet Jishtu
Published: December 2023

Chamabainia cuspidata Wight (Urticaceae), Debregeasia orientalis C.J.Chen (Urticaceae), and Hydrocotyle himalaica P.K.Mukh. (Araliaceae) are being reported here as new additions to the flora of Himachal Pradesh, India. All three species were collected from Khokhan Wildlife Sanctuary in Kullu district. Of these, H. himalaica also forms an addition to the flora of western Himalayan region. Detailed description, distribution, information on habitat and colour photographs of all three species are provided for easy identification in the field.
Association Between Delays in Time to Bystander CPR and Survival for Witnessed Cardiac Arrest in the United States
Authors: Nguyen Dan D. , Spertus John A. , Kennedy Kevin F. , Gupta Kashvi , Uzendu Anezi I. , McNally Bryan F. , Chan Paul S.
Published: December 2023

BACKGROUND:

Prompt initiation of bystander cardiopulmonary resuscitation (CPR) is critical to survival for out-of-hospital cardiac arrest (OHCA). However, the association between delays in bystander CPR and OHCA survival is poorly understood.

METHODS:

In this observational study using a nationally representative US registry, we identified patients who received bystander CPR from a layperson for a witnessed OHCA from 2013 to 2021. Hierarchical logistic regression was used to estimate the association between time to CPR (<1 minute versus 2–3, 4–5, 6–7, 8–9, and ≥10-minute intervals) and survival to hospital discharge and favorable neurological survival (survival to discharge with cerebral performance category of 1 or 2 [ie, without severe neurological disability]).

RESULTS:

Of 78 048 patients with a witnessed OHCA treated with bystander CPR, the mean age was 63.5±15.7 years and 25, 197 (32.3%) were women. The median time to bystander CPR was 2 (1–5) minutes, with 10% of patients having a≥10-minute delay before initiation of CPR. Overall, 15 000 (19.2%) patients survived to hospital discharge and 13 159 (16.9%) had favorable neurological survival. There was a graded inverse relationship between time to bystander CPR and survival to hospital discharge (
P
for trend <0.001). Compared with patients who received CPR within 1 minute, those with a time to CPR of 2 to 3 minutes were 9% less likely to survive to discharge (adjusted odds ratio, 0.91 [95% CI, 0.87–0.95]) and those with a time to CPR 4 to 5 minutes were 27% less likely to survive (adjusted odds ratio, 0.73 [95% CI, 0.68–0.77]). A similar graded inverse relationship was found between time to bystander CPR and favorable neurological survival (
P
for trend <0.001).

CONCLUSIONS:

Among patients with witnessed OHCA, there was a dose-response relationship between delays in bystander initiation of CPR and lower survival rates.
A naturalized diploid Fragaria sp. (Rosaceae) found in southern Chile as revealed by morphological, ploidy and cytogenetic analyses
Authors: FIGUEROA CARLOS R. , QUILODRÁN MANUEL , PEÑAILILLO PATRICIO , BAEZA CARLOS M. , ARREY-SALAS OSCAR
Published: December 2023

Fragaria genus has a worldwide distribution and different ploidy levels. The only wild Fragaria species described in Chile is the octoploid Fragaria chiloensis. In a group of Fragaria accessions from southern Chile including Fragaria chiloensis subsp. chiloensis f. patagonica individuals, an accession named Fragaria-MEN, caught our attention because it shows notable phenotypic differences compared to the rest of the accessions. Fragaria-MEN was collected near the Menetue hot springs (Araucania Region, Chile) and differs from the other F. chiloensis plants mainly in leaf morphology. Due to these differences, we carried out a full morphology description of Fragaria-MEN individuals and then a characterization of the chromosomes and genome size to verify the ploidy level. Morphological analysis reveals close vegetative and reproductive characteristics shared with the non-native diploid Fragaria vesca ‘Hawaii’ species. We also observed a DNA amount according to the diploidy (2n = 2× = 14) revealed by cytological analysis of chromosomes. We propose Fragaria-MEN as F. vesca population that should have been introduced and now is naturalized in the Araucania Region of Chile.
A new species, Hoya honglenae and the first report of H. acuminata and H. phuwuaensis (Apocynaceae, Asclepiadoideae) in the flora of Vietnam
Authors: NGUYEN VAN CANH , AVERYANOV LEONID V. , NGUYEN QUOC BAO , DANG VAN SON , NGUYEN VAN KHUONG , MAISAK TATIANA V. , TRUONG BA VUONG
Published: December 2023

Three species of the genus Hoya (Apocynaceae, Asclepiadoideae) are newly reported for the flora of Vietnam. One species, Hoya honglenae, is described and illustrated as new to science, and two species, H. acuminata and H. phuwuaensis, are reported as new national records known earlier, respectively, in Bhutan, Bangladesh, NE India, W China, Myanmar; and NE Thailand. The new species discovered in Phu Quoc Island (Kien Giang Province) morphologically is most close to H. phuwuaensis, but differs in the entire, straight leaf margin, leaves sparsely white speckled adaxially and dirty purple speckled abaxially, smaller yellow flowers, conoid, obtuse, distally up-cured outer angle of corona lobes, and much longer anther appendages. The paper provides morphological descriptions, data on habitat, phenology, distribution, estimated conservation status, taxonomic notes, a list of studied specimens, and color illustrations for all studied species. Taking into consideration our new data, the genus in Vietnam currently includes 44 species.
Severe Convective Storms in Limited Instability Organized by Pattern and Distribution
Authors: Campbell Trevor A. , Lackmann Gary M. , Molina Maria J. , Parker Matthew D.
Published: December 2023

Severe convection occurring in high-shear, low-CAPE (HSLC) environments is a common cool-season threat in the southeastern United States. Previous studies of HSLC convection document the increased operational challenges that these environments present compared to their high-CAPE counterparts, corresponding to higher false-alarm ratios and lower probability of detection for severe watches and warnings. These environments can exhibit rapid destabilization in the hours prior to convection, sometimes associated with the release of potential instability. Here, we use self-organizing maps (SOMs) to objectively identify environmental patterns accompanying HSLC cool-season severe events and associate them with variations in severe weather frequency and distribution. Large-scale patterns exhibit modest variation within the HSLC subclass, featuring strong surface cyclones accompanied by vigorous upper-tropospheric troughs and northward-extending regions of instability, consistent with prior studies. In most patterns, severe weather occurs immediately ahead of a cold front. Other convective ingredients, such as lower-tropospheric vertical wind shear, near-surface equivalent potential temperature (θe) advection, and the release of potential instability, varied more significantly across patterns. No single variable used to train SOMs consistently demonstrated differences in the distribution of severe weather occurrence across patterns. Comparison of SOMs based on upper and lower quartiles of severe occurrence demonstrated that the release of potential instability was most consistently associated with higher-impact events in comparison to other convective ingredients. Overall, we find that previously developed HSLC composite parameters reasonably identify high-impact HSLC events.

Significance Statement

Even when atmospheric instability is not optimal for severe convective storms, in some situations they can still occur, presenting increased challenges to forecasters. These marginal environments may occur at night or during the cool season, when people are less attuned to severe weather threats. Here, we use a sorting algorithm to classify different weather patterns accompanying such storms, and we distinguish which specific patterns and weather system features are most strongly associated with severe storms. Our goals are to increase situational awareness for forecasters and to improve understanding of the processes leading to severe convection in marginal environments.
Clinical Characteristics and Management of Peripancreatic Arterial Aneurysms: A 20-year Experience
Authors: Kang Jihee , Kim Sejun , Yang Shin-Seok , Kim Young-Wook , Do Young-Soo , Park Kwang-Bo , Park Yang-Jin
Published: December 2023

Pancreaticoduodenal and gastroduodenal artery aneurysms (PDAAs and GDAAs) are rare visceral aneurysms. Considering the rupture risk regardless of size, treatment should be provided promptly. We reviewed the characteristics and management of peripancreatic aneurysms in a retrospective, single-center review of consecutive patients with PDAAs and GDAAs between 2000 and 2022. Demographics, clinical characteristics, radiologic features, treatment, and outcomes were recorded. Nineteen PDAAs and seven GDAAs were identified in 24 patients. The median sizes of the PDAAs and GDAAs were 21 mm (range: 8–50 mm) and 14 mm (range: 11–32 mm), respectively. There were 4 ruptured cases (15.4%). Ten aneurysms (38.5%) had concomitant visceral aneurysms, and 16 (61.6%) were associated with celiac pathology. Aneurysms were managed using endovascular in 12 (46.2%), surgical in 4 (15.4%), and combined methods in 3 (11.5%) cases; 7 patients (26.9%) were lost to follow-up or refused treatments. During a median 13.8-month follow-up (range: 1–147.6), two complications (7.7%) occurred including pancreatitis and coil migration into the superior mesenteric artery after embolization within 30 days. After 30 days, aorto-common hepatic artery bypass graft stenosis was identified in one PDAA. Depending on the characteristics of peripancreatic aneurysms, endovascular, surgical, and hybrid approaches might all be practical treatment options.
The Logic of Hatred: Pentecostal Normativity in Political Public Spheres in Zambia
Authors: Kaunda Chammah
Published: December 2023

This article draws upon Ubuntu philosophy to reframe and construct a pentecostal constructive theology of hatred. It critiques contemporary manifestations of public hatred within Pentecostalism in Zambia, particularly in relation to the Christian nation clause in the constitution. The article argues that constitutionalizing Christianity perpetuates pentecostal normativity in political public spheres, institutionalizing religious-based political hatred. The exclusive reliance on pentecostal literal exegesis of scriptures fosters hierarchical dynamics, enforces norms, and obstructs dissenting voices and religious pluralistic character of the nation. The article contends Ubuntu constructive spirituality of hatred is essential for developing functional, moral, prophetic leadership and a just democratic nation. It proposes a theology of mutually transformative constructive hatred of evil as a means of countering prevailing destructive hatred in public discourse.
Rejoicing in God’s World and Delighting in Humankind: Proverbs 8.1–11, 22–23, 30–35: Address to the Opening Convocation of the 2023–24 Academic Year at Yale Divinity School
Authors: Morgan Teresa
Published: December 2023

Yale Divinity School begins the academic year with an ‘Opening Convocation’, a service of thanksgiving and dedication which includes a short speech, drawing on a bible reading, normally given by a member of the faculty.
Perspectives on Being a Bishop’s Chaplain
Authors: Knights Chris
Published: December 2023

In this article, the role of a chaplain to Church of England bishop is described and reflected on.
Relationship Between Export and Economic Growth: Evidence from West African Countries
Authors: Kulu Evans
Published: December 2023

The export-led growth hypothesis (ELGH) postulates that export is a major driver of economic growth. This study tests this hypothesis and further analyses the determinants of exports in the case of West African countries. An annual panel data spanning from 2008 to 2018 was used. Findings from the system GMM and OLS estimations validate the ELGH in West Africa. The results also reveal that foreign direct investment, employment, remittances, land area and infrastructure are significant boosters of export while population, real effective exchange rate and taxes on international trade are detrimental to export performance in the region. The study recommends the relaxation of taxes especially on international trade to encourage businesses that produce to feed the export sectors, provide an enabling environment for businesses and also attract foreign investors.

JEL Codes: F14, F21, O55
Constitutive modeling and simulation of polyethylene foam under quasi-static and impact loading
Authors: Fu Zhiqiang , Zhang Wujie , Zhao Tong , Wang Yan , Duan Liying , Liu Haozhe
Published: December 2023

In this paper, quasi-static and dynamic compression experiments were carried out on polyethylene foam by a universal material testing machine and a drop tower impact device. The mechanical response characteristics and energy absorption capacity of polyethylene foam under quasi-static and moderate strain rate (4 × 10−3–102s−1) loading conditions were obtained. An improved constitutive model of strain-rate term coupling strain and strain rate was established based on the Sherwood–Frost phenomenological constitutive model and Johnson–Cook constitutive model. Low Density Foam model combined in the finite element software ABAQUS with the improved constitutive model was used as the parameter definition of polyethylene foam material in the simulation. The drop-tower impact tests at different heights were simulated, and the simulation results were compared with the actual drop tower impact test results. The results showed that the peak acceleration errors between simulation and experiment were less than 7.1%, verifying the accuracy of the constitutive model. This study provides a method of constitutive models and finite element simulation to the performance of polymer foams.
Mechanical characterization of lattice structure produced by additive manufacturing under torsion and compression
Authors: Akbay Özgün Ceren , Özdemir Burak , Bahçe Erkan , Emir Ender , Uslu Uysal Mine
Published: December 2023

In the present paper, the torsion and compression behaviors of lattice structures were studied. The PLA (Polylactic Acid) materials were used in assembly and produced by additive manufacturing method. The structure and lattice behaviors were investigated by Digital Image Correlation (DIC) system during experimental study. Models created using three different unit cell model as Trunch Octa Dense, Trunch Octa Light, Body Diagonals With Nodes and two different, 70 mm and 140 mm, total length size. The influence of the unit cell model, cell size on the strength of the structure were studied by compression and torsion experiments. The maximum compressive stress and maximum torsion were obtained and their deformations were presented. The highest maximum torque was determined in Body Diagonals With Nodes cell model and 140 mm due to the fact that the cell model structure compatible with torsion. The highest compressive stress was determined in Trunch Octa Light cell model and 140 mm cell length.
Progressive damage analysis for fatigue life prediction in plain weave composites: A multi-scale approach
Authors: Ghanavaty Amir Mohammad , Mosalmani Reza , Shishesaz Mohammad
Published: December 2023

This study introduces an analytical micromechanical model considering progressive damage designed to predict the elastic and strength properties of plain weave composites subjected to fatigue loading. The presented model is composed of a multi-scale micromechanical model, wherein a progressive damage mechanism has been incorporated. During the development of this multi-scale micromechanical model, a representative volume element was chosen and homogenized, utilizing assumptions pertaining to identical out-of-plane stresses and in-plane strains. These assumptions satisfy the conditions of equilibrium and displacement continuity in the representative volume element and, through a three-step process, enhance the model’s accuracy in applying the damage model and predicting the elastic properties of plain weave composites under static loading. Subsequently, the damage mechanism was progressively developed by accounting for the crucial role of matrix crack growth. This was achieved by employing the kinetic theory of fracture for polymers and integrating it with the multi-scale micromechanical model. Ultimately, the elastic and strength properties of plain weave composites under fatigue loading were predicted. A comparison of the results derived from the present model with those available in the literature demonstrated a high degree of agreement.
Mode Ⅰ–Governed fracture energy and maximum normal traction of a CFRP rod
Authors: Tobata Yuta , Naito Kimiyoshi , Tanks Jonathon
Published: December 2023

This study develops a double cantilever beam test by using a specific fixture for measuring the representative critical energy release rate of rigid composite rods. Carbon fiber reinforced epoxy composite rod was used for the evaluation. Finite element analysis applying Cohesive Zone Model was used to estimate the relationship between load and displacement. In addition, for verifying the effect of specimen width on the measurement, the representative critical energy release rate was estimated and compared with reference to the crack length measured from the center or outer tip of the crack. The numerical results showed close value to that of experiment. This suggests that an effective representative critical energy release rate can be measured by the proposed method.
Reducing delamination risk with response surface methodology-supported drilling analysis for Nomex® aramid fiber composites
Authors: Yarar Eser
Published: December 2023

This article presents a comprehensive experimental investigation into the drilling behavior of Nomex®, a type of aramid fiber. The study specifically examines the impact of various cutting parameters and drill bit types on drilling outcomes. While Nomex® offers many advantages, difficult chip evacuation during drilling of aramid fiber composites can lead to surface defects and delamination. The research aims to explore how drilling parameters—such as spindle speed, feed rate—and four distinct drill bit types affect drilling performance. The analysis encompasses factors such as thrust force, torque, and surface roughness, studied under different drilling conditions and with various drill bit types. Moreover, the research assesses peeling and push-out delamination factors to gain insights into drill bit and coating characteristics. An examination of burr and chipping further enhances the comprehension of drilling performance. To determine the most effective drilling conditions, the study employs multi-response optimization. The optimal drilling performance is achieved with a combination of a 0.1 mm/rev feed rate, 1402.82 r/min spindle speed, and HSS-TiN drill type. This configuration successfully integrates responses, resulting in a composite desirability value of 0.95.
Reported Policies, Guidance, and Related Resources for the Determination of Special Education and Related Services
Authors: Kouo Jennifer L. , Harkins-Brown Andrea R. , Phung Vy H.
Published: December 2023

The Individualized Education Program (IEP) contains information that is critical to ensuring that a student with a disability (SWD) is receiving specially designed instruction as well as the appropriate related services and supports to make meaningful progress in the educational system. With varied practices across states, with some practices characterized by a formulaic approach rather than a student-centered decision-making process, the purpose of this review is to summarize the findings of currently available guidance related to determining the type and amount of special education and related services. This review aims to counteract practices that are not in alignment with the Individuals with Disabilities Education Act (IDEA), and to ensure that state and district guidance for IEP development promotes individualized development of special education and related services based on the unique needs of each student. The themes emphasize the importance of individualized, team-based, and flexible decision-making, the application of evidence-based practices, and ensuring clarity within the IEP. The article further presents the complexity of determining special education and related services while also recognizing the true constraints that exist and encroach upon student-centered and data-driven decisions made within IEP Teams.