bluuebunny/crossref_metadata_2025 huggingface dataset:
Covalent-Fragment Screening of Brd4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites
Authors: Olp Michael , Sprague Daniel , Kathman Stefan , Xu Ziyang , Statsyuk Alexandar , Smith Brian
Published: July 2019

Brd4, a member of the bromodomain and extraterminal domain (BET) family, has emerged as a promising epigenetic target in cancer and inflammatory disorders. All reported BET family ligands bind within the bromodomain acetyl-lysine binding sites and competitively inhibit BET protein interaction with acetylated chromatin. Alternative chemical probes that act orthogonally to the highly-conserved acetyl-lysine binding sites may exhibit selectivity within the BET family and avoid recently reported toxicity in clinical trials of BET bromodomain inhibitors. Here, we report the first identification of a ligandable site on a bromodomain outside the acetyl-lysine binding site. Inspired by our computational prediction of hotspots adjacent to non-homologous cysteine residues within the C-terminal Brd4 bromodomain (Brd4-BD2), we performed a mid-throughput mass spectrometry screen to identify cysteine-reactive fragments that covalently and selectively modify Brd4. Subsequent mass spectrometry, NMR and computational docking analyses of electrophilic fragment hits revealed a novel ligandable site near Cys356 that is unique to Brd4 among all human bromodomains. This site is orthogonal to the Brd4-BD2 acetyl-lysine binding site as Cys356 modification did not impact binding of the pan-BET bromodomain inhibitor JQ1 in fluorescence polarization assays. Finally, we tethered covalent fragments to JQ1 and performed NanoBRET assays to provide proof of principle that this orthogonal site can be covalently targeted in intact human cells. Overall, we demonstrate the potential of targeting sites orthogonal to bromodomain acetyl-lysine binding sites to develop bivalent and covalent inhibitors that displace Brd4 from chromatin.
Nickel-Catalyzed Acylation of Aryl Bromides with Acyl Imidazoles
Authors: Zhuo Junming , Zhang Yong , Li Zijian , Li Chao
Published: July 2019

Alkyl imidazolides were herein found to be viable coupling partners for the Ni-catalyzed acylation of aryl bromides. This cross-coupling reaction features a broad substrate scope and be performed in an extremely cost-efficient fashion. Mechanistically, formation of acyl radicals via reduction of imidazolides represents a major departure from other reported radical acylation reactions. Of particular note, extensive studies revealed an intriguing radical chain mechanism and a remarkable CO-extrusion-recombination phenomenon. Finally, the practicality of this cross-coupling was demonstrated with a gram-scale reaction for the synthesis of a furan diterpenoid natural product.
Nanoparticle synthesis approaches at a glance
Authors: Wali Muhammad  , Iqra Haleem  , Naimat Ullah  , Muhammad Qasim Khan  , Senthil Kumar N
Published: July 2019

Nanotechnology has opened a new era for scientists and engineers to build nanomaterials with diverse applications. Nowadays, nanotechnology plays a vital role in each and every sector due to its extraordinary physical and chemical properties. It deals with development and synthesis of variety of nanoparticles (NPs), which ranging from 1 to 100 nm. The major approaches used for the synthesis of NPs are top to bottom and bottom to up which mainly included physical, chemical and biological methodologies. This mini review highlights synthesis of NPs through various approaches specifically targeted biological route.
Evaluation of antibacterial and in vivo wound healing activity of carbon dot nanoparticles
Authors: H Muktha , R Sharath , Nagaraju Kottam  , S Srinath , Y Randhir
Published: July 2019

Treating post-surgical wound is one of the major challenges in the field of medical Science due to the several disadvantages posed by the antibiotics. The antimicrobial and Wound healing activity of metal based nanoparticles were well known, but the effects of carbon dot nanoparticles (C-Dots) are less explored. In the present study a wet chemical method for the synthesis of C-Dots from sucrose, glucose and fructose was developed and they were characterized by UV-Visible, Fluorescent spectroscopic techniques and the pharmaceutical applications such as antibacterial and the wound healing activities were evaluated. The study revealed that the C-Dots synthesized from Sucrose (SCD) and Glucose (GCD) showed potent antibacterial activity against both positive and negative bacterial strains at 12.5µl/ml (0.1 ± 0.003) and Fructose (FCD) at 50 µl/ml (0.1 ± 0.01) compared to the vehicle Control (0.61 ± 0.06). The wound healing of SCD (367.8 ± 15.2) was observed better than the Control (280.8 ± 10.72) and FCD (326.8 ± 9.41). GCD (166.8 ± 10.83) skin tissues indicated best healing as compared to FCD (135.8 ± 8.29), SCD (157.3 ± 16.97) and Control (135.8 ± 8.29). The results suggest that C-Dots applied topically possess wound healing activity and have potential applications as a bacteriostatic agent.
Planning workshop in a Listening and Reception Group in Mental Health / Oficina de planejamento num grupo de Escuta e Acolhimento em Saúde Mental / Taller de planificación en un grupo de Escuta y Acogida en Salud Mental
Authors: Barros Adriana Lima , Pedrosa José Ivo
Published: July 2019

Objetivo: Planejar as ações a serem realizadas no ano de 2019 no Grupo de Escuta e Acolhimento em saúde mental de maneira participativa e atendendo aos conteúdos dos integrantes do grupo possibilitando o fortalecimento da corresponsabilização bem como a produção de saberes de forma integrada com a equipe. Metodologia: trata-se de um relato de experiência de uma oficina de planejamento realizada no grupo de escuta e acolhimento. Trata – se de um grupo de apoio em saúde mental. Nas atividades de Oficina os participantes são chamados a construir junto, fazer, realizar, ser partícipe da ação que era uma das intenções da atividade. Resultados: A metodologia da oficina favorece a participação, colocou o usuário da saúde mental como autor do planejamento das ações do grupo, fortaleceu o processo criativo e construtivo na relação dos usuários com a equipe que acompanha os usuários. Conclusão: O trabalho com na saúde mental é uma importante estratégia de fortalecimento de autonomia e as oficinas auxiliam no processo participativo.Descritores: Saúde Mental. Grupos de apoio. Oficinas de trabalho
Teenagers sexual and reproductive health promotion: experience report / Promoção da saúde sexual e reprodutiva de adolescentes: relato de experiência / Promoción de la salud sexual y reproductiva de adolescentes..
Authors: Soares Pires Galvão Mariana Portela , Macêdo Edileusa Dos Santos , Evangelista de Araújo Telma Maria
Published: July 2019

Objetivo: descrever a experiência de uma estratégia educativa voltada para a saúde sexual e reprodutiva de adolescentes. Metodologia: trata-se de um relato de experiência resultado da realização de intervenções educativas voltadas para a saúde sexual e reprodutiva de adolescentes estudantes de uma escola pública localizada no município de Teresina e vinculada ao Programa Saúde na Escola, desenvolvidas no período de março a maio de 2017. As atividades foram executadas pela enfermeira e pela dentista da equipe de saúde da família e abrangeram um quantitativo de 95 adolescentes estudantes do ensino médio com faixa etária entre 15 e 18 anos. Resultados: houve discussões a respeito das principais Infecções Sexualmente Transmissíveis e métodos contraceptivos utilizando materiais didáticos e ilustrativos e adotando estratégias participativas e problematizadoras. Conclusão: observou-se que esta abordagem diferenciada motivou os jovens a aprender, analisar e avaliar as fontes de informações, se tornarem capazes de fazer escolhas inteligentes e mudar o seu comportamento.Descritores: Adolescente. Sexualidade. Promoção da Saúde.
Applicability of action research as a methodological approach with Community Health Agents: report of experience / Aplicabilidade da pesquisa-ação como abordagem metodológica com Agentes Comunitários de Saúde: relato de experiência / Aplicabilidad de la pesquisa-acción como abordaje metodológico con agentes comunitarios de salud..
Authors: Rodrigues Ana Paula Brito , Sales Jaqueline Carvalho e Silva
Published: July 2019

Objetivo: relatar a experiência de uma mestranda, na aplicabilidade da pesquisa-ação como abordagem metodológica, tendo como participantes Agentes Comunitários de Saúde. Metodologia: trata-se de estudo descritivo, do tipo relato de experiência, desenvolvido em uma Unidade Básica de Saúde, na cidade de Teresina, Piauí, Brasil. Este relato foi construído a partir da prática vivenciada por uma mestranda, durante a coleta de dados de seu Trabalho de Conclusão de Mestrado no qual utilizou a abordagem metodológica da pesquisa-ação, nos meses de fevereiro e março de 2019. Resultados: a experiência da aplicação da abordagem metodológica da pesquisa-ação com Agentes Comunitários de Saúde com a realização de uma reunião de negociação e dois seminários temáticos, com dinâmicas apoiadas no Método Criativo Sensível, sendo elas Brainstormig e Recorte e Colagem, permitiu a produção de dados para posterior análise e troca de conhecimento, pois ao fim de cada seminário foram realizadas miniexposições relacionadas a temática. Considerações finais: a metodologia da pesquisa-ação permitiu ao participante em um sítio crítico e reflexivo, o potencializa como um transformador de realidade, logo melhora a sua atuação e fortalece a atenção básica.Descritores: Metodologia; Pesquisa Qualitativa; Agentes Comunitários de Saúde; Enfermagem
LivingMind: who cares for you, takes care of the other/ VivaMente: quem cuida de si, já cuida do outro/ VivaMente: quien cuida de sí, ya cuida del outro
Authors: Andrade Risocelly Dos Santos , OLIVEIRA MILLA JANE CARVALHO DE , ROCHA SILVANA SANTIAGO DA
Published: July 2019

Objetivo: apresentar o relato de experiência de ações de promoção da saúde desenvolvidas em um grupo operativo com profissionais de uma equipe da Estratégia Saúde da Família e Núcleo Ampliado de Saúde da Família e Atenção Básica em um município do nordeste brasileiro. Metodologia: trata-se de um estudo descritivo, do tipo relato de experiência, produzido a partir de reflexões das autoras diante das suas práticas profissionais, especialmente quanto a condução do referido grupo, denominado VivaMente. Utilizou-se o diário de campo como ferramenta de registro para a produção das informações e sistematização do relato. Resultados: os espaços de encontros possibilitam refletir sobre os benefícios que as ações de promoção da saúde podem gerar. O grupo VivaMente oportunizou aos profissionais espaços de fala e escuta, os participantes puderam expor aflições e angústias, compreender conflitos, estimular a resiliência e estabelecer relações equilibradas em equipe. Considerações Finais: Esta experiência possibilitou crescimento profissional e pessoal bastante significativo por entender o quanto à utilização de tecnologias leves e ações psicoeducativas mostraram-se estratégias eficazes na promoção da saúde, especialmente quando se refere ao profissional da área.Descritores: Profissional da saúde. Promoção da saúde. Qualidade de vida.
Health education as a social, collective practice: experience report / Educação em saúde como prática social, coletiva: relato de experiência / Educación en salud como práctica social..
Authors: Luz Paulo Cesar De Moura , Tajra Fábio Solon
Published: July 2019

Objetivo: apresentar o relato de experiência de práticas de educação em saúde em um município do nordeste brasileiro como prática social / coletiva. Metodologia: trata-se de um estudo descritivo, do tipo relato de experiência, produzido a partir de reflexões do autor diante das suas práticas profissionais. As informações foram produzidas e analisadas de forma sistematizada por meio de um diário de campo reflexivo. Resultados: A estratégia da problematização subsidiou a identificação do problema, discussão dos possíveis fatores e determinantes, a teorização, as hipóteses de solução e propiciou a implementação das soluções geradas no processo, com destaque à roda de quarteirão na comunidade. Posteriormente, foi realizada a avaliação da intervenção, subsidiada pela Matriz FOFA. Considerações finais: Observou-se a necessidade de alavancar o desenvolvimento de ações de promoção da saúde. Acredita-se que essa ação possa ter disparado reflexões entre os participantes, além de ter oportunizado possível transformação, sobretudo, nas práticas dos profissionais da ESF e sob uma perspectiva teórico-metodológica. Descritores: Promoção da Saúde. Educação em Saúde. Estratégia Saúde da Família. Hanseníase.
Screening of cognitive deficits in bedridden eldery: experience report / Rastreio de déficit cognitivo em idosos acamados: relato de experiência/ Detección de déficits cognitivos en los ancianos acamados: relato de experiencia
Authors: Nunes Ana Paula Moura Pontes , Da Silva Joaquim José Marques , Carvalho Samuel Moura , Paiva Adriana De Azevedo , Mascarenhas Márcio Dênis Medeiros , Campelo Viriato
Published: July 2019

Objetivo: relatar a experiência no rastreio de déficit cognitivo em idosos acamados no domicilio. Metodologia: trata-se de um estudo descritivo, do tipo relato de experiência, desenvolvido com 30 idosos atendidos pela Estratégia de Saúde da Família de Teresina-PI, no período de agosto a outubro de 2018. Resultados: a experiência demonstrou a eficácia do MEEM para avaliação do estado mental de idosos, pois possibilitou a identificação de funções cognitivas. Foi observado, ainda, a necessidade de um acompanhamento sistemático e regular aos idosos que não possuíam condições de comparecer até a unidade de saúde, os quais apresentavam alguma patologia crônica. Considerações finais: A aplicação desse instrumento denotou para o grupo ser um instrumento de baixo custo e tecnologia a disposição dos profissionais da atenção primária em saúde dando substrato na obtenção de informações subsidiem tanto o diagnóstico etiológico do quadro em questão quanto o planejamento e execução das medidas terapêuticas e de reabilitação a serem realizadas em cada caso.Descritores: Demência. Depressão. Assistência a Idosos. Estratégia Saúde da Família.
DAMPAK KEKERASAN DALAM RUMAH TANGGA TERHADAP TINGKAT PERAWATAN DIRI
Authors: Purwati Eka , Herniyatun H , Astutiningrum Diah
Published: July 2019

Data of national commission of women (2005) in 2005 shows that there has been 455 cases of domestic violence, domestic violence is either physical or non physical, done actively or in a passive way (not done), desired by the perpetrator, and no adverse effect on the victim (physical or psychological). The effect can be seen from the daily victims of domestic violence. Self care is one of daily activities of the victim. There are various reasons for the lack of self care physical fatigue and loss of consciousness.The study is aimed to determine the influence of domestic violence on the level self care. This is a non experimental study using cross sectional approach. The samples consist of 30 respondents. The data analysis technique is Chi Square.Analysis of the data indicated a significant count of p=1.000 physical abuse, p=1.000 psychical abuse, p=1.000 economic abuse, p=1.000 sexual abuse. p > 0.05 means that there is no significant effect among the physical, emotional, economic, and sexual domestic violence with the level of self care. While the results of p count of domestic violence with self care show p 1.000 or p > 0,05. Keywords: Domestic Violence, Self Care.
VIDEO MEDIA PEMBELAJARAN PERAWATAN LUKA ULKUS DIABETES MELLITUS
Authors: Suwaryo Putra Agina Widyaswara , Kristianto Heri
Published: July 2019

The learning process is very important to distribute or transfer the knowledge of the teachers or lecturers to students. The application requires a sample or samples of nursing actions, for example the theory that describes the treatment of wounds it will be understood when it is accompanied by a video that is directly applicable wound care performed by nurses to patients (real and the method can play a role). So there needs to be a solution or alternative to solve the problem.Method of product design; instructional media, which produces video instructional media. Video media that has been created contains ulcer wound care diabetes mellitus duration of 25 minutes 37 seconds. Video content on the reviews wound ulcer diabetes mellitus, causes, the occurrence of injury, investigation and physical examination needs to be done to determine the diagnosis or problem. Keywords: Video instructional media, ulcer wound care
GAMBARAN SIKAP PENDIDIKAN KESEHATAN DENGAN ROLE PLAYING TENTANG PENCEGAHAN SEKS BEBAS PADA PADA MAHASISWA PRODI D III KEBIDANAN
Authors: Puspitaningrum Dewi , Istiana Siti
Published: July 2019

Free sex is an exploration or try and as an outlet for fun. Based on the above phenomenon, we need a health education, which is expected to role-playing method of prevention can change the behavior of free sex free sex positive prevention, where the method of role playing is a way of mastering the learning materials through the development of students' imagination and appreciation. This study aims to describe the health education on the prevention of sexual role playing freely. The method used is descriptive number of 90 student population, with a sample of 47 female students with simple random sampling technique. The research data collection by using instruments such as questionnaires and role playing scenarios.The results of this study indicate the attitude of the respondent before health education with the support of role playing as many as 28 respondents (59.6%) and that do not support as many as 19 respondents (40.4%). And after health education with role playing obtained that supports as many as 34 respondents (72.3%) and that do not support as many as 13 people (27.7%). The results of this study has been no improvement after the method of role playing, so that the learning methods that lead on the prevention of free sex easier terstimulus expected positive behavior on the prevention of free sex. Suggestions of this study can stimulate positive behavior in the prevention of teen sex, emphasizing preventive health curriculum on sex, as well as improve the community involved in supporting the prevention of free sex attitudes regardless of it's taboo. Keywords: attitudes of health education, preventive free sex, role playing
HUBUNGAN KETERSEDIAAN FASILITAS PENUNJANG TERHADAP KEBERHASILAN PEMBERIAN ASI EKSKLUSIF PADA IBU YANG BEKERJA SEBAGAI TENAGA KESEHATAN
Authors: Budiyanto B , Asti Arnika Dwi , Yuwono Podo
Published: July 2019

In 2013, UNICEF states that 136.7 million babies were born around the world and only 32.6% were exclusively breastfed. Riskesdas data coverage in the Indonesian Exclusive breastfeeding fluctuate and tend to decrease from 31.0% in 2010 to 30.2% in 2013 28% exclusive breastfeeding failure because mothers have to work. A research conducted in the health center Hartatik Bahorok Langkat (2010) obtained 20% of health workers providing exclusive breastfeeding and 80% did not give exclusive breastfeeding. From the results of research in the village Yuliarsi Sawangan Depok West Java (2012), 66.7% of working mothers had supporting facilities for exclusive breastfeeding in the workplace and 33.3% did not have supporting facilities. In PKU Muhammadiyah Gombong Hospital there are 32 female health workers who have toddlers.This study is to determine the correlation between the availability of supporting facilities for exclusive breastfeeding women with the succeed of exclusive breastfeeding of mothers who work as health care givers in PKU Muhammadiyah Gombong Hospital. This study  is an analytic survey research using cross sectional approach. The samples consist of 32 respondents with 6 months - 5 years children taken by using total sampling technique. Data processing technique is SPSS 17 computer program with chi-square statistical test. Of 3.1% of respondents give exclusive breastfeeding and 96.9% are non­exclusive. 90.6% of respondents give formula milk. Based on SPSS calculations using chi-square test no facilities are associated with exclusive breastfeeding. Keywords; Exclusive breastfeeding, facilities
GAMBARAN PERAN KADER DALAM PELAKSANAAN PROGRAM PERENCANAAN PERSALINAN DAN PENCEGAHAN KOMPLIKASI (P4K) DI WILAYAH KERJA PUSKESMAS PADURESO KABUPATEN KEBUMEN
Authors: Kusumastuti K , Novyriana Eka , Utami Dwi
Published: July 2019

Mortality and morbidity is a big problem in a developing  country such as Indonesia. Minister of Health in 2007 planned a program of labor Planning and Complications Prevention (Indonesian=P4K) by using stickers as efforts to accelerate the decline in infant mortality rate (IMR) and maternal mortality rate (MMR). By implementation of this Program, there should be a good role of midwives, kader, religious leaders, community leaders, husbands, pregnant women and families.This study is to find out the overview of kader’s role in labor planning program and complication Prevention in Padureso Kebumen.This is a descriptive research using observasional design. There are 37 respondents as the samples research by using simple random sampling. The instruments are questioner and interview.The  overview of kader’s role in labor planning program and complication Prevention in Padureso Kebumen is categorized good (43.2%), kader’s role in filling sticker format is categorized bad (27.0%), kader’s role in facilitating the family is categorized good (32.4%), kader’s role in gaining agreement is categorized (54.1%), monitoring result is categorized bad (62.2%), kader’s role in evaluating result is categorized bad (67.6%), and kader’s role in performing report is categorized bad (59%). Keywords:    kader’s role, labor planning program and complication Prevention implementation
PENGARUH POSISI MENERAN MIRING KIRI DENGAN KEJADIAN RUPTURE PERINEUM DI BPS SUGIYATI PETANAHAN
Authors: Astuti Dyah Puji , Handoyo H , Pangestika Dewi Ayu
Published: July 2019

Bleeding  of post partum it be came the first reason 40% mother died in Indonesia. The way of birth caused the second of bluding after atonia uteri, it happened nearly the first given birth, the happened of rupture perineum it be caused by the mother factor paritas and the distant of given birth, or the story of given birth, the mother psycology, the elacitas perineum, ekstraksi vacum, the given birth position, the heavy of baby body and episiotomi. The happening became rupture perineum, it could cause bluding and infection in the parturition time.This study is  to know the influence of birth position towards the incident perineum ruptured during delivery babies in BPS Sugiyati Petanahan.This method of this study was quast exsperiment. The subject of these study were 43 women which had delivery babies. There were 22 women used half sit down position and 21 women used left side position. Data were collected by observation and analyzed by chi-square. This study show that   (1) from 43 women given birth which they did given birth in BPS Sugiyati Petanahan , for the half sit down position was done by 22 women (51,16%), while the other21 women were used left side position (48,84%); (2) 26 women (60,47%) who had delivery babies had perineum ruptured in the left side positition many of 17 women (39,53%) and on the half sit down position many of 9 (20,93%), while the mother given birth did not had rupture many of 17 (39,53%)  in the left side position they were 4 (9,30%) and the half sit down position they were 13 (30,23%). (3) statistical analyzed by chi square showed significant difference perineum ruptured incident betwen half sit down position and left side position p= 0,007 (p < 0,05). Keywords: birth position, delivery babies, left side position, half sit down position
PENGARUH STIMULASI PEMBERIAN TABLET HISAP VITAMIN CTERHADAP PENINGKATAN SEKRESI SALIVA PADA PASIEN GAGALGINJAL KRONIK YANGMENJALANI TERAPI HEMODIALISADI RS PKU MUHAMMADIYAH GOMBONG
Authors: Utoyo Bambang , Yuwono Podo , Tri Kusumawati Wening
Published: July 2019

Chronic renal failure is a progressive deterioration in kidney function and irreversible, in where the body is unable to maintain fluid balance and electrolyte metabolism. Inpractice, patients must limit fluid diet to prevent complications. However, such action may affect some aspect of the human body, that is dry mouth or xerostomiadue to decrease saliva production. To reduce patient complaint, actions which can be done is to stimulate gland salivary with chemical stimulation using lozenges sour taste vitamin C. The aim of this study is to the determine the stimulation effect of the vitamin C lozenges provision to increase salivary secretion in patients with chronic renal failure undergoing hemodialysis therapy in PKU Muhammadiyah Gombong Hospital.This study used a quasi experimental design with pretest — postest design. Samples amounts 42 respondents, consisting of 21 respondents control and 21 respondents intervention by using Purposive Sampling technique. Data analysis technique using Paired t Test to determine whether there were significant differences in salivary secretion in the pretest and postest.Based on a statistical test Paired t Test found a significant increase in the salivary secretion between pretest saliva and postest one intervention group with a value of p=0,003. In conclusion, stimulation of vitamin C lozenges giving has affect to increase saliva secretion in patients with chronic renal failure undergoing hemodialysis therapy in PKU Muhammadiyah Gombong Hospital. Keywords: stimulation, secretion of saliva, chronic renal failure
KEPENTINGAN BERSAMA PERAWAT-DOKTER DENGAN KUALITAS PELAYANAN KEPERAWATAN
Authors: Anggarawati Tuti , Wulan Sari Novita
Published: July 2019

Nurse is as front line of component health care provider, so it determine the image of hospital. So the quality of nursing care is ahigh impactin the quality of health services. Nurse-physician relationship is a significant role in providing health services to patients. Collaboration between nurse-physician relationships are the foundation of a broader, not only serves to protect the rights, powers and responsibilities of nurses and doctors, but also serves to improve nursing care. This study aimed to know relationship quality nurse-physician collaboration: relationship of common interest with the quality nursing services. The methods used in this study was descriptive analytic cross sectional design of the study on nurses and doctors in general hospitals Tugurejo Semarangin accordance with the inclusion and exclusion criteria of the sample at 186 with a sampling technique in probability sampling with stratified random sampling. Bivariate data analysis using Chi Square.The result show that there are a relationshipof common interest with nursing services (p= 0,000).   Keywords : Nursing services, collaboration, common interest
PENERAPAN TINDAKAN KEPERAWATAN GENERALIS TERHADAP KECEMASAN SISWA SMA MENGHADAPI UJIAN NASIONAL
Authors: Agustin Ike Mardiyati , Septiana Miss , Asti Arnika Dwi
Published: July 2019

Ujian nasional (UN) merupakan suatu tahapan untuk mengukur pencapaian standar kompetensi siswa lulusan nasional pada jenjang satuan pendidikan tingkat SMA. Ujian nasional sering disebut sebagai salah satu sumber kecemasan siswa karena adanya perasaan tertekan, khawatir, dan takut akan kegagalan, yang banyak dirasakan siswa saat menghadapi UN. Berdasarkan hal tersebut dibutuhkan suatu bentuk upaya penanganan dan pencegahan untuk mengatasi kecemasan siswa SMA dalam menghadapi UN melalui tindakan keperawatan.Tujuan penulisan ini adalah memberikan gambaran hasil penerapan tindakan keperawatan generalis terhadap tingkat kecemasan siswa SMA menghadapi ujian nasional. Metode yang digunakan adalah deskripif analitik, pada 64 orang siswa SMA. Hasil penelitian ini menunjukan tingkat kecemasan siswa SMA menghadapi ujian adalah sedang,  penerapan tindakan keperawatan generalis menunjukan penurunan tanda dan gejala kecemasan paling banyak pada aspek perilaku dengan peningkatan kemampuan tertinggi adalah kemampuan melakukan teknik 5 jari.Tindakan keperawatan generalis ini direkomendasikan untuk mengatasi tingkat kecemasan sedang pada siswa yang mengahadapi ujian nasional. Kata Kunci: Ujian Nasional, Kecemasan, Siswa SMA, Tindakan keperawatan generalis.
PERUBAHAN KUALITAS HIDUP DAN KENYAMANAN SEHARI-HARI DENGAN SWISS BALL EXERCISE PADA SKOLIOSIS SEDANG
Authors: Fitriyani Aris , Hartati H , Handoyo H
Published: July 2019

Scoliosis is a disorder of the spine in the form of abnormal lateral curvature, it can occur in one or more vertebral regions. Approximately, 4% of all aged 10-14 years experience scoliosis. Therefore, it is necessary to act to reduce the degree of scoliosis therapy. This study aimed to determine the influence of the Swiss Ball Exercise (SBE) to decrease the degree of light idiopathic scoliosis and the quality of life as well as everyday comfort in aged 6-25 years.Type of quasi-experimental research or quasy experiment with pre-experimental design pre post test one group design is equipped with in-depth interviews at 3 participants. The total sample of 24 respondents gets Swiss ball exercise. This research was conducted at RSOP in 2014. The analysis used was Wilcoxon test.The results of the study 37.3% aged 19-25 years and 91.7% were female. The degree of scoliosis before SBE 91.7% had 21-40 degrees. After SBE for  3 months did not occur difference in the degree of scoliosis but there were improvements in the quality and comfort of the everyday that is not rigid, reduced pain, feeling stronger / not easy to accomplish, and more healthy so be able to do daily activities well and tolerance due to the pull curvature of the spine.It can be concluded that SBE is effective for improvement of quality of life and everyday comfort at moderate scoliosis and reduce the degree of scoliosis <21, a mild degree. Keywords: Swiss ball exercise, Degree of Scoliosis
KONSEP DIRI PENDERITA TB PARU DI RS PKU MUHAMMADIYAH GOMBONG
Authors: Saraswati Rina , Hasanah Nur , Al Ummah Muhammad Basirun
Published: July 2019

Introduction: The self-concept is all thoughts, beliefs and faiths that make the person know about him and affect his contact with others. Usually self-concept of pulmonary tuberculosis patients is impaired resulting from physical changes such as becoming physically thinner, paler, frequent coughing, body weaknesses and decrease of physical ability. Based on preliminary studies on eight respondents 75% experiencing body image disorder, 75% self-ideal disorder, 100% self-role disorder, 50% self-esteem disorder.The aim of this researrch is to determine self-concept of pulmonary tuberculosis patients in PKU Muhammadiyah Hospital of Gombong.The present study used descriptive quantitative method with survey approach. The total samples were 31 people taken by purposive sampling technique. The data were taken by questionnaires and analyzed using univariate analysis.The frequency distribution based on the self-concept were less (83.9%), mediocre (9.7%), and good category (6.5%). The body image were less (83.9%), mediocre (9.7%), good (6.5%). The self-ideal were less (90.3%), and mediocre category (9.7%). Personal identity were less (58.1%), enough (22.6%), and good category (19.4%). The self-role were less (54.8%), good (25.8%), and mediocre category (19.4%). Self-esteem were less (51.6%), mediocre (32.3%), and good category (16.1%).The largest percentage of the self-concept, body image, self-ideal, personal identity, self-role, and self-esteem of pulmonary tuberculosis patients was less category. Keywords: self-concept, body image, self-ideal, personal identity, self-role, self-esteem, pulmonary tuberculosis patients
GLASGOW COMA SCALE (GCS), TEKANAN DARAH DAN KADAR HEMOGLOBIN SEBAGAI PREDIKTOR KEMATIANPADA PASIEN CEDERA KEPALA
Authors: Sumarno S , Hidajat Moch. , Rini Ika Setyo
Published: July 2019

The number of incidence and mortality of patients with traumatic brain injury (TBI) is high, so it is called for better service, on the other hand healthcare care facilities, particularly bed of intensive care unit (ICU) limited. So often the hospital should perform a selection against patients. Mortality predictors can be used as tool for selection. The aims of this research is to gain a predictive model of mortality in isolativeTBI patients using a standardized examination in Emergency Department. Design of this study is a observational study with prospective approach. Respondents totaled 49 person byconsecutive sampling.The results of this research show that there is a correlation between all the independence variables with mortality of the patient.GCS (p<0,001, r=0,732), TDS (p=0,005, r=0,420), MAP (p=0,005, r=0,429), Hb (p=0,048, r=0,272). The result of logistic regression showed that GCS is the most dominant factor related to patient mortality is GCS (p=0,002, correlation coefisient = - 0,906). Keywords : Traumatic brain injury, mortality predictor, GCS, components of GCS
HUBUNGAN PENGETAHUAN ORANG TUA TENTANG MAKANAN JAJANAN DENGAN KEJADIAN DIARE PADA ANAK SD NEGERI 1 BUAYAN KECAMATAN BUAYAN KABUPATEN KEBUMEN
Authors: Ernawati E , Maryani Asih
Published: July 2019

Snack foods that are less qualified health and nutrition will threaten the health of school-age children as gastrointestinal diseases, one of which is diarrhea.This study aims to determine the relationship of parental knowledge about street food with the incidence of diarrhea in children SD Negeri 1 Buayan District of Kebumen.This study uses descriptive correlative with retrospective approach. The study population 192 respondents. The research sample 66 respondents. This study was conducted in February-March 2016. The samples were taken using simple random sampling technique. Analysis of data using the Kolmogorov-Smirnov correlation test with significance level of 0.05. Based on the research results, the majority of parental knowledge about good hawker food as much as 53 (80.3%) of respondents and elementary school children who are not suffering from diarrhea were 58 (87.9%) persons. The results of the analysis with the Kolmogorov-Smirnov can be known p-value of 0.008 with (p <0.05) so that there is a significant relationship between parental knowledge about street food with the incidence of diarrhea in children SD Negeri 1 Buayan District of Kebumen.There is a relationship between parental knowledge about street food with the incidence of diarrhea in children SD Negeri 1 Buayan District of Kebumen. Keywords: Diarrhea, Food Snacks, Knowledge
KOMBINASI PIJAT PUNGGUNG DAN ENDORPHIN TERHADAP PRODUKSI ASI PADA IBU POST PARTUM
Authors: Dewi Adinda Putri Sari , Indrayani Eni , Khanifah Rina
Published: July 2019

The high infant mortality rate in Indonesia can be prevented through early breastfeeding (ASI) and exclusive breastfeeding.Combination Back Massage and Endorphin is one of interventions that hopped to help post partum mothers in increasing breast milk production and to support breastfeed for the newborn. To find out the effectiveness of combination of back massage and endorphin to breast milk production in postpartum mothers. The study used quasi experiment  using post test only design with control group. The samples were taken using  consecutive sampling with a total of  22  samples for each group (intervention and control). Bivariat  analysis used  chi square  with  a significance level of p <0.05. The results indicate that there is a  difference in milk production between the intervention and the control groups with an OR of 0,2 (95% CI: 0,060 to 0,770). Parity and frequency of breastfeeding have significant correlation with breast milk production. Mother’s age, parity, work, obesity, and frequency of breastfeeding have no significant correlation with breast milk production. The conclusions of this research are combination of back massage and endorphin to breast milk production.
CASE REPORT: AFIRMASI POSITIF PADA HARGA DIRI RENDAH SITUASIONAL PASIEN FRAKTUR FEMUR
Authors: Agustin Ike Mardiati , Handayani Sri
Published: July 2019

Patients with fractures will experience a decrease in physical condition, dependence on medical actions that result in changes in the patient's life, disability and role change due to physical limitations can raise the psychological problem of low situational self-esteem. The purpose of this paper describes the results of the application of positive affirmation therapy on low self-esteem situational patients fracture of the femur. The methodology used was analytic descriptive with case study approach on 5 patients of femur fracture who experienced low situational self esteem. Results The application of positive affirmation therapy is effective in lowering the symptoms of low self-esteem situational symptoms with medical diagnoses of femoral fracture with a decrease of cognitive, affective, physiological, behavioral and social signs. A positive affirmation therapy recommendation is recommended for patients with physical problems with psychological low self-esteem situational problems
PEMBERIAN TERAPI OKSIGEN PADA PASIEN ACUTE CORONARY SYNDROME DENGAN CHEST PAIN DI INSTALASI GAWAT DARURAT
Authors: Rachmawati Dewi
Published: July 2019

Emergency nurses’s somehow actually routine use of supplemental oxygen theraphy in chest pain patient because of acute coronary syndrome is done, without know that routine oxygen theraphy may potentially cause harm. The used method was by collecting and analyzing related textbook and articles with the use of supplemental oxygen theraphy in chest pain patient because of acute coronary syndrome. The literatures were obtained from textbook and electronic articles such as ScienceDirect, World Health Organization, Google Scholar, PubMed and ClinicalKey with textbook and article criteria that were published from 2000 to 2015. The result is routine use of supplemental oxygen theraphy for Acute Coronary Syndrome (ACS) with chest pain based on physical assessment and level of oxygen saturation. The patient of ACS with chest pain without sign and symtoms hypoxia or respiratory distress, syok and heart failure with oxygen saturation ≥94% then without oxygen theraphy, if the patient with one or all of sign and symtoms above with oxygen saturation <94% then oxygen therapy can be given with initial administration is 4 L/minute and in titration until oxygen saturation ≥94% with administered more than than 6 hours. The next reassessment is done to the patient. If the condition of the airway patent, the patient can breathe spontaneously, normal breathing (especially rhythm, depth and no respiratory muscle use), respiratory or oxygenation problems minimally and oxygen saturation > 94% then oxygen therapy can be given with nasal cannul 4-6L / minute or simple mask from 6- 10L / minute. If the patient is emergency condition with airway patent, spontaneous breathing with adequate depth ventilation and requiring oxygen in high concentrations may then be provided with a non-rebreathing mask. The conclucion is routine use of supplemental oxygen theraphy in acute coronary syndrom with chest pain not recommended and the oxygen theraphy can be given if the patient with oxygen saturation <94% or sign and symtoms hypoxia or respiratory distress, breathlessness, syok and heart failure Key word :Acute Coronary Syndrome, Chest Pain, Emergency Unit, Oxygen Therapy
PENGARUH PEMBERIAN EKSTRAK AKAR PASAK BUMI (EURYCOMA LONGIFORA JACK) TERSTANDAR TERHADAP GAMBARAN HISTOPATOLOGIK TESTIS TIKUS WISTAR
Authors: Miyarso Condro Suro , Widiastuti Tri Cahyani , Kiromah Naelaz Zukhruf Wakhidatul
Published: July 2019

The root of pasak bumi (Eurycoma longifolia, Jack) is one of plant from Indonesia known as aphrodisiac. The study about its standardized extract as aphrodisiac was show increasing libido, testosterone level, FSH and LH on male rats. This study was conducted to evaluate testosterone level and histopathological changes of the testes of male rats of standardized extract of pasak bumi root. There are 50 old male rats which ages 3-4 months old divided to five groups. Group I as negative control was administered aquadestilata. Group II as positive control was administered testosterone (Andriol®). Group III, IV and V ware given standardized extract of pasak bumi root at the dose 50, 100 and 200 mg/kg body weight Respectively. The extract was given orally twice a day for six days and forty nine days and then the testes was taken out on 7th and 50th day. The histopathological of the testes was evaluated using quantitative parameter by the presence of testes weight, number and diameter of Leydig cells. Testosterone level was taken on 7th and 50th day used ELISA method. The results were analyzed using parametric test, one way ANOVA (P<0,05), post hoc Dunnet (2-sided) (P < 0,05). The result of this study shows that the standardized extract of pasak bumi root was not effect on histopathological changes of the testes but it could increased the level of testosterone m at the dose 100 and 200 mg/kg body weight.  Key word : Eurycoma longifolia, Jack, aphrodisiac, histopathological testes testosteron
KUALITAS BAKTERIOLOGI AIR MINUM ISI ULANG DITINJAU DARI METODE DISINFEKSI YANG DIGUNAKAN DI KABUPATEN NGAWI
Authors: Prayitno Suhadi
Published: July 2019

Cases, concerns and complaints in public about refill drinking water,  low businessmen DAMIU are checked routinely product processed as well as the mandate of the Consumer Protection Act, Kepmerindag RI and Permenkes RI on monitoring refill drinking water background for the author to conduct research. Purpose to describe the bacteriological quality of refill drinking water in terms of disinfection method used in District Ngawi. This method is descriptive study and cluster sampling to 49 samples DAMIU in District Ngawi with the results of the method used, namely ultraviolet disinfection, ozonation and reverse  osmosis. The results bacteriological quality (total coliforms) of any disinfection method shows a different picture, which shows the method of disinfection reverse osmosis bacteriological quality with the percentage of 50.00%, followed by ozonation method of 46.15% and the latter by the ultraviolet method percentage value 44.12 %. The ability of any reduction in total coliform disinfection method shows a different picture, in which the reverse osmosis method of disinfection showed total coliform reduction percentage of 94.08%, followed by ozonation method of 91.46% and the latter by the ultraviolet method percentage value 86.09%. The conclusion willingness, support and cooperation of all stakeholders is needed to improve the supervision, guidance and inspection of the quality of refill drinking water in Ngawi. Key word : water, disinfection, coliform
PROFIL KROMATOGRAFI EKSTRAK ETANOL KELOPAK BUNGA MAMBROS HIJAU
Authors: Handayani Eka Wuri
Published: July 2019

Green patchouli or rosella (Hibiscus sabdariffa L.) has many properties and traditionally the flower petals can be used to treat diseases. Based on this, this study aims to identify the chemical content of ethanol extract chromatography from green mrambos flower petals (Hibiscus sabdariffa L.). This research was carried out with the extraction of green mrambos flower petals using maceration method with ethenol 96% solvent. Identification of chemical components was done by tube test and paper chromatography and thin layer chromatography.The results showed that the results of tube test and ethanol extract chromatography from green mrambos flower petals (Hibiscus sabdariffa L.) obtained the presence of flavonoid compounds, polyphenols and saponins which these three compounds could be efficacious as antifungi.  Key word : Ethanol extract of green mambambos flower, tube test, chromatography
GAMBARAN KUALITAS HIDUP LANSIA DI WILAYAH KERJA PUSKESMAS BOJONG I KABUPATEN PEKALONGAN
Authors: Aniyati Sri , Kamalah Aisyah Dzil
Published: July 2019

Elderly is the last stage of development of human life. Elderly often experience physical, psychological, social or problems with the environment around them. This is make an affects in elderly’re quality of life. This study aims to determine the quality of life of the elderly who live in working area of puskesmas Bojong I Kabupeten Pekalongan. This research uses descriptive quantitative research design. Researchers describe QAL elderly by using a WHOQAL measuring instrument is a Quality Of Life (QAL) by WHO. The Quality Of Life (QAL) picture of the elderly in the working area of the Puskesmas Bojong I is largely adequate (74%). (72%) is sufficient, social (74%) enough and environment (64%) enough. In the future, efforts can be made to improve the quality of life of the elderly both physically, psychologically, socially and environmentally.
ANXIETY LEVELS DURING MENARCHE AMONG FEMALE STUDENTS AT STATE JUNIOR HIGH SCHOOL 1 OF AYAH
Authors: Sumarsih Tri , Nurfadillah Marina , Dwi Asti Arnika
Published: July 2019

Menarche is the early menstruation that usually occurs at the age of 10-14 years. It is the culmination of a series of changes in adolescents who are stepping on adulthood. These changes bring about various questions, feelings of confusion, fear and anxiety. The purpose to know the anxiety during menarche (first menstruation) of female students of State Junior High School 1 of Ayah. This study uses descriptive method with cross sectional approach. The populations are all female students of State Junior High School 1 of Ayah who have experienced menarche. Samples were taken by using simple random sampling technique on 170 respondents. Instrument used in this study was DASS (Depression Anxiety Stress Scale). Data was analyzed by using univariate analysis. Based on the research conducted, there were 67 respondents (39.4%) experienced light anxiety during menarche. It is advisable for adolescents who are going into adulthood to get lot of knowledge about menarche.Key word : anxiety, menarche, teenager
GAMBARAN TINGKAT PENGETAHUAN KELUARGA TENTANG BAHAYA PEROKOK PASIF DI DUSUN JARANAN PANGGUNGHARJO SEWON BANTUL TAHUN 2015
Authors: Yuliana Fatimah Eka , - Maryana , - Sugeng
Published: July 2019

The effects of cigarette smoking are not only borne by those who smoke, but also felt by passive smokers. Passive smokers are more inhale of cigarrette smoke with more particles of a substance. The data of Susenas shows the prevalence of passive smokers in Indonesia amounted to 48,9% or 97.560.002 inhabitans, which consist of 31,88% in men and 66% in women. Surveys shows that more than 90% of active smokers have admitted to smoking in home when they were together with other family members.This research aims to know the description of family's level knowledge  about the danger of passive smoker in  Dusun Jaranan Panggungharjo Sewon Bantul. The research method used was descriptive survey. The research was done in 2015. The research location was in the village of Jaranan, Panggungharjo Sewon Bantul, Yogyakarta. Subjects of this research were members of the family in Jaranan, Panggungharjo, Sewon Bantul who become passieve smokers with productive age (15 – 64 years old) as many as 71 people. This research used proportional random sampling.  The research instrument was a questionnaire of 30 statements. Data were analyzed using frequency distribution. In this research showed that 64,7% of respondent were aged over 31 years, 43,6% of respondent had a recent education junior high school,54,92% were housewifes, 93,36% of respondent got the smoke at home, and 64,78% of respondent were inhaled cigarette smoke average <1 hour. From data processing obtained results of the research showed family's level knowledge  about the danger of passive smoker was good by 51 respondent (71,8%), qiute as much as 20 respondent (28,2%), and no respondent who had less knowledge level. The description of family's level knowledge  about the danger of passive smoker in  Dusun Jaranan Panggungharjo Sewon Bantul was in good categories (71,8%).  Key word : family, knowledge, the dangers of passive smokers