bluuebunny/crossref_metadata_2025 huggingface dataset:
Rare Case Presentation And Reporting of an Unusual Cause of Loin Mass.
Authors: Jamshed Bashir  , Syed Razi Muhammad  , Asma Jabeen
Published: June 2024

Objective: To determine the presentation and pathological findings of a rare case of huge abdominal mass.Material and Methods: This case study of “rare case presentation and reporting of an unusual cause of lionmass "was carried out in Muhammad medical college Mirpurkhas. over a period of one year from January 2012to January 2013 in the department of surgery.Retro Peritoneal abdominal mass was sent to hospital laboratory for biopsy and other pathological findings.Results: A 65 years old man was feeling abdominal mass for 25years. During surgery we found a large, round,fatty mass in the retroperitoneal space, which was easily removed by surgery. On further cutting most of the central part of mass was necrosed and partly liquefied and dark brown in colour. Section showed tumor. Tumor wascomposed of variegated tissue predominantly variable thick vascular channels separated by oval. Spindle andlarge polyhedral cells containing bland nuclei. Their cytoplasm ranged from pale, densely, esinophilic to granularin appearance. Benign looking kidney tissue with feature of chronic pyelonephritis was also present.Conclusion: We concluded that the abdominal mass from the kidney / retroperitoneal soft tissue was benignmesenchyme tumor more in favor of angiomyolipoma.
UNVEILING THE DYNAMICS OF HYBRID AMBIDEXTERITY: A STUDY ON EVOLVING ORGANIZATIONAL ROLES FOR EMPLOYEES AND LEADERS IN PROCESS-DRIVEN ENTERPRISES
Authors:   Faculty of Management, University of Gdansk, Sopot, Poland, Siciński Jędrzej
Published: June 2024

In response to the contemporary challenges in the economic environment, organizations are compelled to seek management concepts and methods that enable dynamic adaptation to factors generated in their surroundings. This pursuit has led to a quest for an integrative perspective on various management formulas within the systemic and structural dimensions of an organization. This article employs the principles of ambidexterity and Business Process Management (BPM). The study, conducted through a survey involving 332 large organizations in Poland (both ambidextrous organizations and those that have not implemented this concept), delves into the association between process-oriented employee and leadership roles concerning diverse approaches to achieving ambidexterity. The findings provide an overview of the surveyed large organizations, shedding light on the implemented roles of employees, leaders and process owners within the context of various ambidextrous strategies (structural, contextual, sequential, hybrid). All considered employee and leadership roles supported the ambidexterity strategy. The strength of the association was moderate at best.
Performance optimisation techniques for Conflict-free Replicated Data Types (CRDT)
Authors: Rabeshko Yurii , Turbal Yurii
Published: June 2024

The research relevance is determined by the need for distributed data handling optimisation that does not cause conflicts during replication, since the introduction of such types of data leads to an increase in the need for their optimisation and performance. The study aims to develop techniques to improve the efficiency of various types of data with conflict-free replication. To achieve this goal, the methods of analysis and experimentation were used. The study results demonstrate that the use of certain optimised methods of conflict-free data types in replication leads to a significant improvement in efficiency and reduction of resource costs. The results show that caching and precomputation, asynchronous synchronisation, and local processing are the most effective methods for improving the efficiency of Conflict-free Replicated Data Types. It is established that the choice of a specific method for improving the performance of Conflict-free Replicated Data Types should be justified and based on a careful analysis of the requirements and characteristics of a particular distributed system. This takes into account user needs, data criticality, edit frequency, etc. The research includes the development and optimisation of synchronisation algorithms that significantly improve the performance of these types of data in distributed systems. The work includes simple software implementations for detailed analysis and study of methods for optimising the performance of data types in conflict-free replications. The introduction of distributed computing has made it possible to optimise the processes of data replication and synchronisation, which helps to reduce overheads and improve system performance. It is concluded that the study is of practical importance since the use of optimised conflict-free data types with replication in real distributed systems can improve their efficiency and reliability. The practical significance of the study lies in the possibility of applying optimised methods of data types with conflict-free replication in real distributed systems, which will increase their performance and ensure efficient operation under conditions of high load and limited resource potential
Simultaneous Estimation of Quercetine and Betanine by RP-HPLC from Herbal Formulations Used in Nutritional Deficiencies
Authors:   Assistant Professor, Dept. of Pharmaceutical science, Sardar Patel University, V.V. Nagar-388120, Gujarat, India, Patel Bhavna A. , Patel Pathikkumar J. ,   Associate Professor, Smt. S M Shah Pharmacy College, Mahemdavad, Ahmedabad, Gujarat-387130, India
Published: June 2024

Background: Medicinal plants have curative properties due to the presence of various complex chemical substances of different compositions, which are found as secondary plant metabolites in one or more parts of the plants. Moringa oleifera from Moringaceae and Beta vulgaris root are, native to India, grows in the tropical and subtropical regions of the world. It is commonly known as 'drumstick tree' or 'horseradish tree' or 'miracle tree’. Incorporation of more herbal powder leads to much complexity. Above plants were chosen for their utmost nutritional values. Result: Herbal tablet and granules were prepared and evaluated further for various Physico-chemical parameters as a nutritional supplement. Promising results indicate that prepared formulations have potential as supplements. Conclusion: Present communication mainly focused on estimation of marker components by Reverse Phase-High Performance Liquid Chromatography. It showed the presence of enough number of secondary metabolites and minerals which can be easily consumed by all age groups.
Delitos económicos: los llamados delitos de cuello blanco
Authors: Pizarro Carballo Fernando José
Published: June 2024

Los primeros estudios criminológicos destacaban la criminalidad como aquel fenómeno que se dirige en contrariedad a la colectividad, no obstante, esa percepción de criminalidad subyace sus orígenes en los estratos más bajos de la sociedad, impulsada en gran medida por una serie de factores propios de esta clase social, por lo que históricamente se ha dejado por fuera del análisis una delincuencia no convencional, de cuello blanco, criminalidad económica, o delitos económicos entre otros sinónimos, lo que ha ocasionado que el análisis de los delitos económicos sea ambiguo e indeterminado, propiciando que la criminalidad económica permanezca impune ante el control represivo del estado. Estos delitos son cometidos por personas de alto poder económico y político, provenientes de los estratos más altos de la sociedad, aprovechando su posición privilegiada. Debido a esta característica, a los delincuentes económicos se les facilita evadir fácilmente la responsabilidad penal y no ser sujeto de crítica y estigmatización, como sí ocurre con los delincuentes comunes. Asimismo, a la hora que se cometen estos actos, se afectan bienes jurídicos supraindividuales e intereses difusos,por lo que este trabajo investigativo mediante una vasta recopilación de información, tiene por objeto poner en evidencia la gran problemática que representan estos delitos, así como las graves implicaciones en la persecución de los delincuentes económicos y las cuantiosas consecuencias que acarrean, ya que estos delitos suelen quedar en la impunidad, lo que eventualmente genera que los delincuentes nunca sean llevados a instancias judiciales para que respondan por sus ilícitos.
La compra del establecimiento comercial como concentración económica
Authors: Paniagua Rodríguez Cristhel , Fallas Amador Vanessa , Castro Anzellini Fabián , Solano Fallas Oscar
Published: June 2024

El presente ensayo presenta una guía especializada en adquisiciones y fusiones corporativas, brindando asesoramiento legal. Cuenta con un manual técnico, dirigido de manera específica a los accionistas minoritarios, su enfoque meticuloso se centra en la toma de decisiones hipotéticas vinculadas a las concentraciones económicas, proporcionando herramientas necesarias para preservar los derechos e intereses de este segmento esencial en el tejido empresarial. En sintonía con todas las obligaciones legales establecidas por Costa Rica respecto a estas operaciones, mostraremos cómo abordar la complejidad de las concentraciones económicas de manera proactiva, este enfoque estratégico no solo limita al cumplimiento normativo, sino que también buscamossobrepasar las expectativas al proporcionar una orientación robusta para un sector de accionistas en específico como lo son los minoristas. Consideramos la importancia crítica de los accionistas minoritarios en el entramado corporativo, por lo que la protección de sus derechos se convierte en un elemento fundamental en el diseño de estrategias y soluciones. Además, la garantía de un proceso transparente y conforme a la legalidad se complementa con la maximización de los beneficios para los accionistas minoritarios, reconociendo su papel esencial en el éxito conjunto de las empresas. Con un compromiso inquebrantable con la integridad, este documento se erige como faro en el paisaje de concentraciones económicas, ofreciendo una orientación práctica y un enfoque propositivo, por lo que brindamos esta guía como un recurso fundamental para aquellos nmersos en procesos de concentración económica y les brindamos una perspectiva clara al enfrentar los retos inherentes a estas complejas transacciones empresariales.
E-government Implementation in Calamba Water District and Public Trust: Basis for Enhancement Program
Authors: Espiel Abby Mae
Published: June 2024

The research comprehensively analyzed the relationship between the e-government implementation of Calamba Water District (CWD) and the level of public trust among the concessionaires. It also delved into the challenges faced by concessionaires in utilizing CWD e-government services and the factors influencing their trust in its implementation. The study employed a descriptive-correlational design and surveyed 397 CWD concessionaires in Calamba, Laguna, who had internet access and were actively engaged with CWD e-government services. Data collection was facilitated using a carefully selected research instrument and was analyzed using statistical treatments including simple mean, Four-point Likert Scale, standard deviation, and Pearson r. The research revealed a significant correlation between CWD's egovernment implementation and the level of public trust among concessionaires. Specifically, the study revealed a substantial link between the level of e-government implementation in terms of ICT infrastructure, online services communication, human capital, privacy and security risks, ease of use, and usefulness of egovernment services and public trust level among the concessionaires in terms of information, service, system quality, technology, and the government institution. It indicated that the higher the level of egovernment implementation, the higher the public trust level among the concessionaires. Based on these findings, the study recommended an enhancement program to improve various aspects of the current egovernment implementation of Calamba Water District. The proposed program focuses on addressing privacy and security risks, enhancing the user-friendliness of CWD e-government services, improving service quality related to ICT infrastructure and online communication, and enhancing the competency of CWD personnel. These enhancements are expected to bolster the overall program and ultimately increase public trust among concessionaires.
En mangesidig recoveryprosess: En metasyntese av evalueringsrapporter om musikkterapi i psykisk helse- og rusfeltet
Authors: Trzebinski Marcus , Tuastad Lars
Published: June 2024

Hensikten med denne artikkelen er å samle og strukturere brukererfaringer fra musikkterapi innen psykisk helse- og rusfeltet i Norge og bidra med ny innsikt i hvilken rolle musikkterapi kan ha i brukernes recoveryprosess. Artikkelen er en metasyntese med utgangspunkt i 8 evalueringsrapporter fra 5 forskjellige kommuner med til sammen 102 deltakere. Analysen er inspirert av stegvis induktiv-deduktiv metode (SDI). Funnene tyder på at recovery kan være en mangesidig prosess hvor musikkterapi kan bidra på flere områder, med flere fellesnevnere mellom psykisk helse- og rusfeltet. Akronymet CHIME, som viser til temaene tilknytning, håp, identitet, mening og myndiggjøring, med utvidelsen D, som viser til utfordringer, består av tema som kan gjenspeile områdene musikkterapi støtter oppunder i brukernes recoveryprosess.
Arte e Revolução
Authors: Ciro Augusto
Published: June 2024

Neste artigo, analisaremos a posição de Marcuse num debate que coloca o autor em algum grau de colisão com o movimento da Living Art e com a New Left. A partir das suas formulações sobre a função da arte na sociedade unidimensional, destacadas nas obras A sociedade como obra de arte (1967), Arte na sociedade unidimensional (1967) e o capítulo Arte e Revolução, do livro Contra-Revolução e Revolta (1972), evidenciaremos as questões relativas ao papel político da arte, sua relação com a sociedade e seu potencial emancipatório, sobretudo na defesa que o autor faz da forma estética e da alienação artística.
The Factors Affecting Learners' Enrollment into STEM Programs in TVET Institutions within Kisumu County, Kenya
Authors: Kevin Otieno, RDN Ochieng
Published: June 2024

There is presently a lot of debate around science, technology, engineering, and mathematics (STEM) programmes and how they prepare trainees for the future economy and innovation. Moreover, the debate has been even more about inclusion of female trainees to pursue STEM programmes in technical, vocational, education, and training (TVET) institutions in Kenya. While this is the scenario, it is important to understand the various factors that motivate or demotivate trainees’ enrollment into these programmes. In this light, this paper seeks to investigate factors that either motivate or demotivate trainees to enroll into STEM programmes and compare the influence of such factors between female and male trainees. The study adopted a survey design where questionnaires and focus group discussions were used as the data collection approaches. 5 TVET institutions, both private and public, within Kisumu County were randomly selected, and purposive sampling used to identify 120 respondents, 87 males and 33 females, for the structured semi-structured questionnaires and case narration. Study findings showed that socioeconomic factors; parents’ level of education and personal factors (self-motivation and confidence and attainment of social and academic satisfaction) are the key factors influencing trainees’ enrolment into STEM programmes in TVET institutions within Kisumu County. However, there was significant difference in motivating factors between female and male trainees for enrolment into STEM programmes. It is recommended that trainees, both male and females, should be given equal opportunities to pursue their careers in STEM.
Socio-Economic Factors Impacting Education Attainment in Primary Schools in Katagum LGA, Bauchi State Nigeria
Authors: Bello Mohammed , K. Chumba Sammy
Published: June 2024

In recognizing education as a fundamental right, Nigeria has striven to eliminate barriers that impede access, ensuring that learners from diverse backgrounds can thrive and contribute meaningfully to society. This endeavor is grounded in the belief that education is not just a privilege but a powerful catalyst for personal growth, social progress, and global harmony. However, despite this, Nigeria has the highest number of children not enrolled in school even globally. This study explores socio economic factors affecting enrollment in primary schools in Katagum Local Government Area in Nigeria. The Human Capital Theory by economists Gary Becker and Theodore Schultz guided this study. A qualitative study, framed within an interpretivism paradigm, drawn on a phenomenology design was used. 29 participants were purposively sampled from the study's population who are stakeholders of primary education including parents, teachers, head teachers and Education Secretary while the data were generated using interviews and focus group discussions and thematically analysed. Trustworthiness was ensured and ethical principles were adhered to. Findings revealed that the stakeholders perceived socio-economic factors affecting enrollment in primary schools as poverty, child labour, distance norms and location of the school, influx of Internally Displaced Persons, belief system and unemployment. It was envisioned that, strategies like abolishing of school fees, shifting socio-cultural norms, introduction of skills acquisition, school's improvement projects and offering financial incentives to poor families would improve and sustain enrollment in primary schools.
The Reliability and Availability of Renewable Energy Sources in Kenya
Authors: Amos Kiprono Keter , Kiplagat Hoseah
Published: June 2024

The research sought to evaluate the reliability and availability of renewable energy sources in Kenya by examining the available literature regarding the state of energy production and consumption of the renewable energy sources. Several studies have been conducted to establish the capacity of the renewable electrical power sources including hydroelectric power, geothermal sources, wind power, solar energy and biofuels. Regarding production of electricity, the existing capacity is barely able to keep up with demand. The research used systematic review as the methodology of collecting relevant data for analysis. Given that more than 38% (2021) of Kenyas electricity comes from hydropower, the situation is particularly difficult during the dry months of the year when water levels are low. Capacity gaps are then compensated by expensive thermal generation based on fossil fuels. Geothermal power has the capacity to be the most significant source of renewable energy with a potential of up to 7000MW. The reliability indices of the renewable energy sources, based on System Average Interruption Frequency Index (SAIFI) are at 1.98 (SAIFI) and at 4.37, based on the Customer Average Interruption Duration Index (CAIDI), which are below the international global standards. The research concluded that increased consumption of electricity, availability of alternate energy sources, amount of restoration time and number of planned interruptions have a significance influence on the reliability of a renewable energy source, with restoration time being the most significant. It is therefore recommended that new technologies and innovations that lead to reduced power interruptions and greenhouse gas emission be adopted.
IMPLEMENTATION OF TECHNOLOGY AND INFORMATION DEVELOPMENTS IN IMPROVING INDONESIAN EDUCATION
Authors: Fitriansyah Aswin
Published: June 2024

This research aims to analyze the implementation of technological and information developments in enhancing education in Indonesia. Using a qualitative descriptive method, this study concludes that the current educational landscape actively leverages technological and information advancements to improve the quality of national education. One crucial step in enhancing the quality of national education involves revitalizing the learning processes. The integration of technology, information, and communication plays a significant role in the learning phases. The utilization of technology, information, and communication can stimulate students' creativity during the learning process. Besides serving as a learning tool, technology, information, and communication can also be used to distribute teaching materials and facilitate communication in the learning process. Thus, the comprehensive use of technology, information, and communication contributes significantly to improving the quality of education in Indonesia.
ПРАВО НА ОБРАЗОВАЊЕ МАЛОЛЕТНИКА ТОКОМ ИЗВРШЕЊА КРИВИЧНИХ САНКЦИЈА– НОРМАТИВНО-ПЕНОЛОШКИ ПРИСТУП
Authors: Mirić Filip
Published: June 2024

Образовање је основно људско право. Кроз процес образовања људи стичу знања и вештине потребна за обављање послова којим обезбеђују средства за егзистенцију, поштујући притом моралне и правне норме. Овако одређено, образовање је од изузетног значаја за ресоцијализацију малолетника током извршења кривичних санкција јер се на тај начин стварају неопходни услови за сузбијање криминолошког, кривичноправног и пенолошког поврата. Имајући све ово у виду, у раду ће бити анализирано право на образовање малолетника током извршења кривичних санкција, кроз приказ релевантних одредби најзначајнијих међународноправних аката. Циљ рада је да се укаже на значај образовања као облика третмана. На крају рада ће бити указано и на практичне проблеме приликом остваривања права на образовање у институцијама за извршење кривичних санкција за малолетнике, што раду даје и пенолошки значај.
COMMUNICATION STYLES OF SOCIAL NETWORKS AND CYBERBULLYING
Authors: Banović Silva
Published: June 2024

The research was conducted to examine communication styles on social networks and the prevalence of cyberbullying among the citizens of Bosnia and Herzegovina. The survey included 250 respondents, of both sexes, from the territory of Bosnia and Herzegovina. Respondents answered individually via an online questionnaire. The results showed that social networks are widely used in Bosnia and Herzegovina; as many as 94.8% of respondents use Facebook, 82.3% use Instagram, and 32.9% use Tik Tok. All three communication styles (aggressive, passive, and assertive) are also present when communicating online on social networks. Assertive and passive ways of communicating are more common than aggressive ones. At least a third of the respondents included in this research were exposed to cyberbullying. Along with the numerous advantages of communication via social networks, it has its disadvantages. The existence of victims of violent communication on social networks is a non-negligible fact. There is an obvious necessity to detect and remediate this relatively new social problem, and also the need to provide adequate social and counseling services for the protection of the citizens of Bosnia and Herzegovina against violent online communication.
AKCIONO ISTRAŽIVANJE U FUNKCIJI PREVENCIJE VRŠNJAČKOG NASILJA
Authors: Maran Marijana
Published: June 2024

Sam naziv akcionih istaţivanja ukazuje na pojmove koji podrazumijevaju akciju, promjene, traganje, iznalaţenje, participaciju, fleksibilnost, poboljšanje, unapreĊenje, kreativnost, dijalektiĉnost, povratnu informacija itd. Svaki od nadevenih pojmova je usmjeren na poboljšanje vaspitno-obrazovne prakse. Autori radasu akciono istraţivanje stavili u funkciju prevencije vršnjaĉkog nasilja. Analizirajući nivoe prevencije vršnjaĉkog nasilja (primarni, sekundarni i tercijalni) uvidjeli su znaĉaj preventivnog djelovanja u odnosnu na naknadna dejstva. Efekti ovakvog vida djelovanja posebno su došli do izraţaja u fazama akcionog istraţivanja i njihovim cikliĉnim ponavljanjima. Na uzorku od 426 ispitanika, uĉenika srednje škole, primenjeno je akciono istraţivanje po modeluspiralnog toka, ĉiji su autori Veljko BanĊur i Nikola Potkonjak (1999). Model spiralnog toka, po svojoj strukturi i mogućnosti primjene, posebno je prilogoĊen uslovima u našim školama. Rezultati istraţivanja pokazuju da se primjenom akcionog istraţivanja u funkciji programa prevencije vršnjaĉkog nasilja u srednjoj školi, moţe doprinijeti kvalitativnim promjenama u ponašanju uĉenika, što potvrĊuje ĉinjenicu da se vršnjaĉko nasilje i nasilje uopšte moţe sprijeĉiti kvalitetnom pedagoškom intervencijom i prevencijom, kao i primjenom adekvatnih i kvalitetno osmišljenih programa prevencije prilagoĊenih svim uzrastima u školi, kroz posebne programe prevencije ili u okviru ĉasova razredne zajednice.
PRIKAZ STANJA MALOLJETNIĈKE DELINKVENCIJE NA PODRUĈJU UNSKO-SANSKOG KANTONA
Authors: Balić Rahmanović Smaila
Published: June 2024

Maloljetniĉka delinkvencija je ozbiljan problem s kojim se suoĉava društvo u cijelom svijetu te zahtijeva paţnju i rješavanje na razliĉitim razinama zbog svoje kompleksnosti i osjetljivosti. Mnogobrojni su faktori koji dovode do pojave maloljetniĉke delinkvencije, a zbog svojih specifikacija i uĉestalosti posebno se izdavajaju socio-kulturni faktori meĊu koje ubrajamo: porodicu, školu, slobodno vrijeme, sredstva masovne komunikacije, ratne i postratne prilike, ekonomske krize, siromaštvo, nezaposlenost, urbanizaciju i migraciju. Maloljetniĉka delinkvencija moţe imati dugotrajne negativne posljedice za maloljetnika, porodicu i društvo u cjelini. Djeca koja se bave delinkventnim ponašanjem su sklonija školskom neuspjehu, napuštanju škole, problemima s mentalnim zdravljem i daljnjem kriminalnom ponašanju u odrasloj dobi. Društvo kao cjelina treba biti svjesno problema maloljetniĉke delinkvencije i uloţiti napore u pronalaţenju dugoroĉnih rješenja kako bi se osiguralo zdravo i sigurno okruţenje za sve mlade ljude. Ovaj rad istraţuje prevalenciju maloljetniĉke delinkvencije na podruĉju Unsko-sanskog kantona. Cilj rada je analizom podataka kojima raspolaţe Ministarstvo unutarnjih poslova USK-a utvrditi broj maloljetnih poĉinitelja kaznenih i prekršajnih djela registriranih u protekle tri godine na ovom podruĉju.
RIZICI SOCIJALNOG RAZVOJA REPUBLIKE SRPSKE
Authors: Lepir Ljubo
Published: June 2024

Socijalni razvoj Republike Srpske odreĊen je društveno-ekonomskim procesima karakteristiĉnim za postkonfliktno i tranzicijsko društvo. Socijalna razgradnja društva koja je uslijedila nakon propasti socijalistiĉkog koncepta razvoja intezivirana je posljedicama ratnih sukoba tokom devedesetih godina prošlog vijeka i posljedicama prirodnih nepogoda u prvim decenijama 21. vijeka. U meĊuvremenu su se desili globalni procesi koji su dodatno odredili socijalni razvoj Bosne i Hercegovine i Republike Srpske u njoj. Ekonomske turbulencije na globalnom svjetskom trţištu kapitala, 2007. godine, pandemija korona virusa 2020. i rat u Ukrajini 2022. godine dodatno su poremetili socijalnu stabilnost društva Republike Srpske. Konstantni sukob na relaciji drţava - entitet ĉitavo vrijeme je djelovao kao politiĉki katalizator sve veće socijalne neizvjesnosti graĊana, a posebno onih koji su socijalno najosjetljiviji. Promjene ekonomskog okruţenja, demografski procesi, vanjskopolitiĉki i unutarpolitiĉki kontekst uveliko su uticali na kljuĉne rizike socijalnog razvoja Republike Srpske. Siromašni, djeca i mladi, lica sa invaliditetom, starija lica, ţene i pripadnici manjinskih grupa ĉine socijalno najosjetljivije grupe na ĉijim sudbinama se najzornije mogu identifikovati kljuĉni rizici socijalnog razvoja savremenog društva Republike Srpske, a to su: depopulacija, siromaštvo i ekonomska deprivacija, nezaposlenost, kriza porodice i porodiĉnih vrijednosti, rodna neravnopravnost, ugroţenost mentalnog zdravlja i dr. Ĉlanak se bavi uzrocima i posljedicama pojedinih socijalnih rizika na razvoj Republike Srpske, sa implikacijama na socijalno najosjetljivije kategorije stanovništva.
SAVREMENI DRUŠTVENI MEDIJI I RIZIĈNA SEKSUALNA PONAŠANJA MLADIH
Authors: Jovanoski Nela
Published: June 2024

Seksualno ponašanje mladih nije samo pod uticajem individualnih intenzivnih promena s kojima se adolescenti suoĉavaju, nego je i pod uticajem društvenog okruţenja. Današnja shvatanja mladih odreĊena su procesom globalizacije i formiraju se pod izuzetno snaţnim uticajem masovne kulture i medija. Lakoća korišćenja društvenih medija, njihova dostupnost velikom broju adolescenata, percipirana anonimnost vezano za pruţanje osetljivih tema vezano za pruţanje seksualnih informacija povećala su interesovanje istraţivaĉa za istraţivanje veze izmeĊu izloţenosti seksualnom medijskom sadrţaju i riziĉnim seksualnim ponašanjima mladih što ĉini predmet ovog rada. Cilj rada je ukazivanje na znaĉaj ispitivanja uticaja savremenih društvenih medija na riziĉna ponašanja mladih, sa posebnim osvrtom na to kako se seksualni sadrţaji tumaĉe i inkorporiraju u njihove ţivote.
RIZIĈNA PONAŠANJA I MENTALNO ZDRAVLJE DJECE I MLADIH – RODITELJSKA PERSPEKTIVA
Authors: Zloković Jasminka , Tomac Lucija
Published: June 2024

Adolescencija je vrijeme znaĉajnih psihiĉkih, tjelesnih i društvenih promjena obiljeţeno razvojem stavova i mišljenja o ljudima i okolini te traţenjem sebe i svojega mjesta u promjenjivom svijetu. TakoĊer, ona predstavlja razdoblje visokog rizika za razvoj poteškoća u funkcioniranju liĉnosti i pojavu riziĉnih i disfunkcionalnih ponašanja. Jednu od kljuĉnih dimenzija u ţivotu djeteta predstavljaju odnosi u obitelji i ponašanja njihovih roditelja. Mnogi su rizici u obitelji i široj okolini kojima su izloţena djeca i mladi što (ne)izravno utjeĉe i na njihovo emocionalno funkcioniranje i mentalno zdravlje. Istraţivanje je provedeno 2023. godine na namjernom uzorku od 195 ispitanika, odraslih osoba starijih od 18 godina. Prikupljanje podataka provedeno je anketnim upitnikom kreiran za potrebe ovog istraţivanja. Rezultati ukazuju na niţe procjene emocionalnog funkcioniranja djece i mladih u odnosu na tjelesno i intelektualno funkcioniranje. Odgovori ukazuju na probleme ponašanja djece prema roditeljima, drugoj djeci i sebi samome kao i uoĉene anksioznosti, depresivnih stanja i destruktivnih te na probleme nasilja. Najveći broj ispitanika ne uoĉava riziĉne faktore u obitelj (obiteljsko nasilje, psihiĉka oboljenja, ovisnosti, seksualni poremećaji i dr.) pri ĉemu se najviše istiĉe problem nezdravih ţivotnih stilova unutar obitelji. Zabrinutost za djecu i mlade povezuju s utjecajem medija i virtualnih sadrţaja, izostankom roditeljskih kompetencija, nepoštivanjem roditeljskog autoriteta i ignoriranjem moralnih vrijednosti u obitelji i široj okolini. Ispitanici istiĉu postojanje loših odnosa u obitelji izmeĊu djece i roditelja, ali ne uoĉavaju problem preuranjene seksualne aktivnosti ni sklonosti nasilju, dugotrajna noćna izbivanja ili konzumaciju droga i opijata što je u disparitetu sa sluţbenim pokazateljima. U prevenciji riziĉnih ponašanja kod djece i mladih ispitanici istiĉu znaĉaj ĉimbenika iz spektra komunikacije i pozitivnih odnosa i nenasilnog rješavanja konflikata. Navedeno govori u prilog isticanju i znaĉaju primarne prevencije, poticanju mentalnog zdravlja i mogućnosti osnaţivanja obitelji da bi se djeca i mladi znali nositi sa stresnim situacijama i mnogim drugim svakodnevnim izazovima.
ВЛИЈАНИЕТО НА СЕМЕЈСТВОТО И УЧИЛИШТЕТО ЗА СПРЕЧУВАЊЕ НА СПОРТСКОТО КЛАДЕЊЕ КАЈ МЛАДИТЕ
Authors: Stefanovski Dragan
Published: June 2024

Практикувањето на современото урбано живеење кај младите подразбира и подобар социоекономски статус кај истите. Економската криза со која со децении се соочува населението во Р. Македонија, доведе до дополнително раслојување на населението од кое како најзагрозена е средношколската популација. Во овој контекст се појавуваат најразлични форми низ кои младите се обидуваат да дојдат до средства преку кои соодветно ќе се реализираат. Во трудот кој претставува теоретско емпириска студија, вниманието го насочувам на феноменот хазард и спортско обложување меѓу средношколската популација, од аспект на детектирање на оваа девијантна појава, согледувајќи ја можноста за нејзино попречување од страна на семејството и училиштето. Ќе одговориме на прашањето дали во обложувањето лежи инстиктот за брзо богатење, или пак истото се доживува како забава, пополнување на слободното време и начин на социјализација со своите врсници, надминувајќи ја така општествената изолираност, социјална исклученост како и кризата на идентитет. Ќе се обидеме да одговориме колку семејството, и училиштето преку својот образовен курикулум може да одговори на предизвикот што значи заштита на младиот човек од девијантната појава детектирана во спортското кладење и слични на него обложувања. Воедно, дали дислокацијата на спортските обложувалници на соодветна оддалеченост од образовните установи, позитивно ќе се одрази на правилното трасирање на патот на креативна млада личност.
ULOGA RODITELJA U VASPITANJU DETETA ZA ČUVANJE ZDRAVLJA
Authors: Budimir - Ninković Gordana , Župljanin Melida , Minić Vesna Lj.
Published: June 2024

Brzi razvoj nauke, tehnike i digitalizacije, savremeni naĉin ţivota dece - mladih i odraslih utiĉu na zdravlje. Zdravlje deteta je tema koja najviše privlaĉi paţnju roditelja. Za oĉuvanje zdravlja deteta znĉajno je da roditelji obezbede potrebne uslove da dete odraste u zdravu osobu. Imajući u vidu savremene uslove ţivota, deca su sve više upućena na tehniku- društvene mreţe, a sve manje vremena provode sa roditeljima. Ishrana, vazduh i aktivnosti su polazna osnova zdravlja. S obzirom da dete ima stalnu potrebu da bude aktivno znaĉajno je “praćenje” i usmeravanje. U tom cilju je vaţno da roditelji podstiĉu dete da što više vremena provodi u igri na sveţem vazduhu. Pri tom treba razvijati ljubav prema sportu i kreativnim aktivnostima. U svemu tome uloga roditelja je kompleksna i veoma sloţena. Njihova odgovornost je usmerena na: oĉuvanje zdravlja i sigurnosti dece, unapredjenje njihovog psiho- fiziĉkog razvoja, podsticanje socijalnih veština, praćenje i podršku intelektualnog razvoja. Za uspešan razvoj i vaspitanje roditelji treba da deluju pozitivnim primerom, da budu dosledni, principijelni i umereni.
Optimization for nutritional fortification of wheat–millet composite flour mixture by response surface methodology
Authors: Chaudhary Gaurav , Kumar Monu , Sehrawat Anita Rani , Kumar Sandeep , Tripathi Sachidanand
Published: June 2024

This study intends to optimize the production and evaluation of the nutritional quality of composite flour comprising wheat and millet. The experimental design for the composite flour was laid down using the I-optimal mixture design of response surface methodology (RSM). With an extensive literature survey, wheat, finger millet, barnyard millet, and foxtail millet were selected to understand the health benefits of wheat flour. A total of 24 flour blends were prepared by incorporating wheat flour (40–85%), finger millet flour (5–20%), barnyard millet flour (5–20%), and foxtail millet (5–20%) as independent variables; however, the responses were protein, antinutrient (Tannin), and antioxidants (1,1-diphenyl 2-picryl hydrazyl). The statistical and numerical optimization technique of RSM was used to optimize multiple responses simultaneously. After optimization, eight distinct solutions were obtained using the software. Out of the eight solutions, the best optimum level of fortified mixture was selected and wheat (51.09%), finger millet (20%), barnyard millet (8.91%), and foxtail millet (20%) with protein content (23.19 mg g–1), antinutrient content (9.07 mg g–1), and antioxidant activity (61.52%), along with the highest desirability (0.845), were found to be the best. The optimized mixed flour obtained from wheat and millet blends had superior nutritional properties, making it an appropriate choice for consumers with dietary requirements, particularly those allergic to gluten. Furthermore, the optimized wheat–millet flour is suitable for large-scale production and can be used to improve consumers’ nutrient delivery and protein requirements. The study optimized composite flour through mixture design application and highlighted the applicability of RSM in the food industry. The outcome indicates that fortified flour finds its applicability in the food industry, particularly for products such as biscuits, noodles, pasta, and other bakery items.
Rayleigh analysis and numerical simulations of metal-mesh/ transparent conducting oxide composite transparent electrode
Authors: Ding Yi-Yang , Zou Shuai , Sun Hua , Su Xiao-Dong ,   Jiangsu Key Laboratory of Thin Films, School of Physical Science and Technology, Soochow University, Suzhou 215006, China,   Jiangsu Key Laboratory of Advanced Negative Carbon Technologies, Suzhou 215123, China
Published: June 2024

Transparent conducting oxides (TCOs), especially indium tin oxides (ITOs), have played an important role in realizing optoelectronics devices. Composite electrodes fabricated by introducing different types of metal-meshes into TCO have exhibited improved electric properties as well as good transparency. This technology can also reduce the demand for ITO and provide the candidates of flexible electrodes for wearable devices. Analysis of the electric properties of this type of electrode, such as the variance of the sheet resistance of the composite electrodes with the embedded mesh structure parameters, can provide a theoretical basis for designing and fabricating this electrode. But detailed studies are still lacking. This work focuses on the electrical property analysis of the typical square hole and grid shaped metal mesh-TCO composite electrodes based on Rayleigh model and finite-element simulation, respectively. The electric potential distribution and current density distribution are obtained from the finite element calculations, revealing that the dramatic deformation of the metallic channels in the composite results in the failure of a conventional Rayleigh model for the moderate and high opening rates. Accordingly, we adopt a lattice correction to the Rayleigh model to reduce the channel deformation by increasing the symmetry of the exterior boundary of the lattice cell. A comparison of the results from the simulations with those from the second-order approximation of the lattice-adapted Rayleigh model shows that the new analytic form of the effective conductivity is applicable to a much larger opening-rate range for both the monolayer and the sandwich structures of metal-mesh TCO composite electrodes. The variances of the sheet resistance and the effective conductivity with different material and structure parameters of the composite electrodes are calculated and discussed based on the lattice-adapted Rayleigh approximation. The results are well consistent with experimental results. A comparison of our model with other theoretical models is also made, showing that this lattice-adapted Rayleigh approximation can be used as a simple and efficient theoretical tool to analyze and design the concerned transparent composite electrodes.
A unique multi-synaptic mechanism involving acetylcholine and GABA regulates dopamine release in the nucleus accumbens through early adolescence in male rats
Authors: Iacino Melody C , Stowe Taylor A , Pitts Elizabeth G , Sexton Lacey L , Macauley Shannon L , Ferris Mark J
Published: June 2024

Adolescence is characterized by changes in reward-related behaviors, social behaviors, and decision-making. These behavioral changes are necessary for the transition into adulthood, but they also increase vulnerability to the development of a range of psychiatric disorders. Major reorganization of the dopamine system during adolescence is thought to underlie, in part, the associated behavioral changes and increased vulnerability. Here, we utilized fast scan cyclic voltammetry and microdialysis to examine differences in dopamine release as well as mechanisms that underlie differential dopamine signaling in the nucleus accumbens (NAc) core of adolescent (P28-35) and adult (P70-90) male rats. We show baseline differences between adult and adolescent-stimulated dopamine release in male rats, as well as opposite effects of the α6 nicotinic acetylcholine receptor (nAChR) on modulating dopamine release. The α6-selective blocker, α-conotoxin, increased dopamine release in early adolescent rats, but decreased dopamine release in rats beginning in middle adolescence and extending through adulthood. Strikingly, blockade of GABAA and GABAB receptors revealed that this α6-mediated increase in adolescent dopamine release requires NAc GABA signaling to occur. We confirm the role of α6 nAChRs and GABA in mediating this effect in vivo using microdialysis. Results herein suggest a multisynaptic mechanism potentially unique to the period of development that includes early adolescence, involving acetylcholine acting at α6-containing nAChRs to drive inhibitory GABA tone on dopamine release.
Untargeted Pixel-by-Pixel Imaging of Metabolite Ratio Pairs as a Novel Tool for Biomedical Discovery in Mass Spectrometry Imaging
Authors: Cheng Huiyong , Miller Dawson , Southwell Nneka , Fischer Joshua L. , Taylor Isobel , Salbaum J. Michael , Kappen Claudia , Hu Fenghua , Yang Cha , Gross Steven S. , D’Aurelio Marilena , Chen Qiuying
Published: June 2024

Mass spectrometry imaging (MSI) is a powerful technology used to define the spatial distribution and relative abundance of structurally identified and yet-undefined metabolites across tissue cryosections. While numerous software packages enable pixel-by-pixel imaging of individual metabolites, the research community lacks a discovery tool that images all metabolite abundance ratio pairs. Importantly, recognition of correlated metabolite pairs informs discovery of unanticipated molecules contributing to shared metabolic pathways, uncovers hidden metabolic heterogeneity across cells and tissue subregions, and indicates single-timepoint flux through pathways of interest. Here, we describe the development and implementation of an untargeted R package workflow for pixel-by-pixel ratio imaging of all metabolites detected in an MSI experiment. Considering untargeted MSI studies of murine brain and embryogenesis, we demonstrate that ratio imaging minimizes systematic data variation introduced by sample handling and instrument drift, markedly enhances spatial image resolution, and reveals previously unrecognized metabotype-distinct tissue regions. Furthermore, ratio imaging facilitates identification of novel regional biomarkers and provides anatomical information regarding spatial distribution of metabolite-linked biochemical pathways. The algorithm described herein is applicable to any MSI dataset containing spatial information for metabolites, peptides or proteins, offering a potent tool to enhance knowledge obtained from current spatial metabolite profiling technologies.
Resting natural killer cells promote the progress of colon cancer liver metastasis by elevating tumor-derived sSCF
Authors: Mao Chenchen , Chen Yanyu , Xing Dong , Zhang Teming , Mei Dianfeng , Han Zheng , Xie Wangkai , Long Cong , Lin Yangxuan , Yu Jiaye , Xiang Dan , Lu Mingdong , Shen Xian , Xue Xiangyang
Published: June 2024

The abundance and biological contribution of Natural killer (NK) cells in cancer are controversial. Here, we aim to uncover clinical relevance and cellular roles of NK cells in colon cancer liver metastasis (CCLM)We integrated single-cell RNA sequencing, spatial transcriptomics, and bulk RNA-sequencing datasets to investigate NK cells’ biological properties and functions in the microenvironment of primary and liver metastatic tumors. Results were validated through an in vitro co-culture experiment based on bioinformatics analysis.We used single-cell RNA sequencing and spatial transcriptomics to map the immune cellular landscape of colon cancer and well-matched liver metastatic cancer. We discovered that GZMK+ resting NK cells increased significantly in tumor tissues and were enriched in the tumor regions of both diseases. After combining bulk RNA and clinical data, we observed that these NK cell subsets contributed to a worse prognosis. Meanwhile, KIR2DL4+ activated NK cells exhibited the opposite position and relevance. Pseudotime cell trajectory analysis revealed the evolution of activated to resting NK cells. In vitro experiments further confirmed that tumor-cell-co-cultured NK cells exhibited a resting status, as evidenced by decreased KIR2DL4 expression. Functional experiments finally revealed that NK cells exhibited tumor-activating characteristics by promoting the dissociation and release of SCF on the tumor cells membrane depending on cell-to-cell interaction, as the supernatant of the co-culture system enhanced tumor progression.Together, our findings revealed a population of protumorigenic NK cells that may be exploited for novel therapeutic strategies to improve therapeutic outcomes for patients with CCLM.
Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing
Authors: Zhou Jiale , Zhao Ding , Li Jinze , Kong Deqiang , Li Xiangrui , Zhang Renquan , Liang Yuru , Gao Xun , Qian Yuqiang , Wang Di , Chen Jiahui , Lai Liangxue , Han Yang , Li Zhanjun
Published: June 2024

5-Methylcytosine (m
5
C) is one of the major post-transcriptional modifications in mRNA and is highly involved in the pathogenesis of various diseases. However, the capacity of existing assays for accurately and comprehensively transcriptome-wide m
5
C mapping still needs improvement. Here, we develop a detection method named DRAM (deaminase and reader protein assisted RNA methylation analysis), in which deaminases (APOBEC1 and TadA-8e) are fused with m
5
C reader proteins (ALYREF and YBX1) to identify the m
5
C sites through deamination events neighboring the methylation sites. This antibody-free and bisulfite-free approach provides transcriptome-wide editing regions which are highly overlapped with the publicly available BS-seq datasets and allows for a more stable and comprehensive identification of the m
5
C loci. In addition, DRAM system even supports ultra-low input RNA (10ng) and monitor the dynamic accumulation of cellular m
5
C. We anticipate that the DRAM system could pave the way for uncovering further biological functions of m
5
C modifications.