bluuebunny/crossref_metadata_2025 huggingface dataset:
Interpretational issues with the bifactor model: a commentary on ‘Defining the p-Factor: An Empirical Test of Five Leading Theories’ by Southward, Cheavens, and Coccaro
Authors: Dolan Conor V. , Borsboom Denny
Published: April 2023

Southward, Cheavens, and Coccaro (2022, Psychological Medicine) conducted an ambitious investigation aimed at determining the nature of the general p factor of psychopathology by considering the correlation between the p factor and five candidate constructs. Generally, in this area of research, the bifactor model is preferred to the second order common factor model. In this commentary, we identify several interpretational issues concerning the bifactor model, which are based on a realistic psychometric view of latent variables. These issues may hamper the study of the nature of p factor model using the bifactor model.
Based on human-like variable admittance control for human–robot collaborative motion
Authors: Wang Chengyun , Zhao Jing
Published: April 2023

Admittance control of the robot is an important method to improve human–robot collaborative performance. However, it displays poor matching between admittance parameters and human–robot collaborative motion. This results in poor motion performance when the robot interacts with the changeable environment (human). Therefore, to improve the performance of human–robot collaboration, the human-like variable admittance parameter regulator (HVAPR) based on the change rate of interaction force is proposed by studying the human arm’s static and dynamic admittance parameters in human–human collaborative motion. HVAPR can generate admittance parameters matching with human collaborative motion. To test the performance of the proposed HVAPR, the human–robot collaborative motion experiment based on HVAPR is designed and compared with the variable admittance parameter regulator (VAPR). The satisfaction, recognition ratio, and recognition confidence of the two admittance parameter regulators are statistically analyzed via questionnaire. Simultaneously, the trajectory and interaction force of the robot are analyzed, and the performance of the human–robot collaborative motion is assessed and compared using the trajectory smoothness index and average energy index. The results show that HVAPR is superior to VAPR in human–robot collaborative satisfaction, robot trajectory smoothness, and average energy consumption.
Mid-term follow-up after COVID-19 vaccination in adults with CHD: a prospective study
Authors: Fusco Flavia , Scognamiglio Giancarlo , Roma Anna Selvaggia , Abbate Massimiliana , Papaccioli Giovanni , Merola Assunta , Palma Michela , Borrelli Nunzia , Barracano Rosaria , Correra Anna , Grimaldi Nicola , Ciriello Giovanni Domenico , D’Abbraccio Maurizio , Scavone Cristina , Capuano Annalisa , Sarubbi Berardo
Published: April 2023

Background:

Long-term data on COVID-19 vaccine safety, immunogenicity, and acceptance in adults with CHD are lacking.

Methods:

This is a prospective study including adults with CHD patients undergoing COVID-19 vaccination from January 2021 to June 2022. Data on adverse events, antispike IgG titre, previous or subsequent COVID-19 infection, booster doses, and patients’ attitude towards vaccination were collected.

Results:

Four hundred and ninety CHD patients (36 ± 13 years, 53% male, 94% with moderate/complex defects) were prospectively included: 433 (88%) received a Pfizer–BioNTech mRNA vaccine, 31 (6%) Moderna mRNA vaccine, 23 (5%) AstraZeneca–Oxford ChAdOx1 nCov-19 vaccine, and 3 (0.6%) Janssen Vaccine; 310 (63%) received a booster dose. Median follow-up after vaccination was 1.53 [1.41–1.58] years. No major adverse event was reported. Eighty-two fully vaccinated patients contracted COVID-19 during follow-up after a median of 5.4 [4.3–6.5] months from the last dose. One patient with Ebstein’s disease died from severe COVID-19. Symptoms’ duration in patients who tested positive after vaccination was significantly shorter than in the group tested positive before vaccination (5.5 [3–8] versus 9 [2.2–15] days, p = 0.04). Median antispike IgG titre measured in 280 individuals (57%) at a median of 1.4 [0.7–3.3] months from the last dose was 2381 [901–8307] BAU/ml. Sixty patients (12%) also showed positive antinucleocapsid antibodies, demonstrating previous SARS-COV2 exposure. Twenty-nine percent appeared to have concerns regarding vaccine safety and 42% reported fearing potential effects of the vaccine on their cardiac disease before discussing with their CHD cardiologist.

Conclusion:

COVID-19 vaccines appear safe in the mid-term follow-up in adults with CHD with satisfactory immunogenicity and reduction of symptoms’ duration in case of infection.
Coronary artery bypass grafting in children aged under 1 year: a report of three cases
Authors: Maeda Toshi , Yoshizawa Kosuke , Mori Otohime
Published: April 2023

We performed coronary artery bypass grafting with the internal thoracic artery in three infants. Grafts were patent in all cases. One patient was lost due to chronic heart failure. Coronary artery bypass grafting can be performed even in infancy, and early surgical intervention may be necessary when myocardial ischaemia is recognised.
Militarization and privatization of security: From the War on Drugs to the fight against organized crime in Latin America
Authors: Perret Antoine
Published: April 2023

Fifty-two years ago, in 1971, President Nixon declared the “War on Drugs”, identifying drug abuse as a public enemy in the United States. Since then, US drug policy has been militarized and, more recently, privatized. Every year, the US government increasingly contracts private military and security companies to provide intelligence, logistical support and training to armed forces in drug-producing or drug-transit States. In Latin America, this militarization and privatization has increased the intensity of violence and has complexified domestic situations, to the extent that the existing international legal regimes now seem inappropriate to respond to the challenges posed by the War on Drugs. On the one hand, human rights law does not adequately address situations where the State faces organized crime groups that are able to control territory. On the other hand, international humanitarian law (IHL) was not created to address law enforcement situations, which the War on Drugs and the fight against organized crime ostensibly are.

This article examines the situation in Latin America, looking at examples of different types of situations through the lens of intensity and organization of the group involved and, in some cases, the group's control over territory. It discusses the application of IHL and human rights law (focusing on the inter-American system of human rights) in these situations and their complementarity, and debates how these bodies of law are adapting or may need to be adapted.
A wearable real-time kinetic measurement sensor setup for human locomotion
Authors: Wang Huawei , Basu Akash , Durandau Guillaume , Sartori Massimo
Published: April 2023

Current laboratory-based setups (optical marker cameras + force plates) for human motion measurement require participants to stay in a constrained capture region which forbids rich movement types. This study established a fully wearable system, based on commercially available sensors (inertial measurement units + pressure insoles), that can measure both kinematic and kinetic motion data simultaneously and support wireless frame-by-frame streaming. In addition, its capability and accuracy were tested against a conventional laboratory-based setup. An experiment was conducted, with 9 participants wearing the wearable measurement system and performing 13 daily motion activities, from slow walking to fast running, together with vertical jump, squat, lunge, and single-leg landing, inside the capture space of the laboratory-based motion capture system. The recorded sensor data were post-processed to obtain joint angles, ground reaction forces (GRFs), and joint torques (via multi-body inverse dynamics). Compared to the laboratory-based system, the established wearable measurement system can measure accurate information of all lower limb joint angles (Pearson’sr = 0.929), vertical GRFs (Pearson’sr = 0.954), and ankle joint torques (Pearson’sr = 0.917). Center of pressure (CoP) in the anterior–posterior direction and knee joint torques were fairly matched (Pearson’sr = 0.683 and 0.612, respectively). Calculated hip joint torques and measured medial–lateral CoP did not match with the laboratory-based system (Pearson’sr = 0.21 and 0.47, respectively). Furthermore, both raw and processed datasets are openly accessible (https://doi.org/10.5281/zenodo.6457662). Documentation, data processing codes, and guidelines to establish the real-time wearable kinetic measurement system are also shared (https://github.com/HuaweiWang/WearableMeasurementSystem).
Long‐Term Variation of Dust Devils in East Asia During 1959–2021
Authors: Du P. , Huang Z. , Tang S. , Dong Q. , Bi J. , Yu X. , Gu Q.
Published: April 2023

Dust devils play an important role in dust transport by carrying it from the surface into the atmosphere, especially in summer. However, information on how dust devils changed in the past decades and what caused these changes remains lacking. Based on thermodynamic criteria and ERA5 reanalysis data set, this study investigated the long‐term variation of favorable conditions for dust devil occurrence in East Asia over the past 63 years and defined it as potential dust devil and dusty plume (PDDP) occurrence in hours. Annual mean frequency of PDDP in East Asia was approximately 217.2 hr from 1959 to 2021. An overall downward trend in PDDP frequency has been found over 63 years in East Asia among which strong PDDPs drop significantly at the fastest rate while the weak ones dropped insignificantly. Moreover, PDDP frequency in the Gobi Desert increased but they decreased in the Taklimakan Desert. The monthly variation of PDDP shows a single‐peak structure with a tendency for the peak to move from June to July. For the diurnal changes, PDDP mainly occurred between 10:00 and 16:00 at local time (LT), with over 60% of them happening between 12:00 LT and 14:00 LT. We also found a negative correlation between precipitation and PDDP occurrence. This study provides a comprehensive understanding of favorable conditions for dust devil occurrence in East Asia over the past decades, which is of great importance to further evaluate its impact on climate, environment as well as ecosystem.
Hydrogen May Push Some Exoplanets off a Cliff
Authors: Nov�kov� Julie
Published: April 2023

High-pressure reactions of hydrogen and iron could explain gaps in the distribution of exoplanets.
Validation and refinement of the 2022 European LeukemiaNet genetic risk stratification of acute myeloid leukemia
Authors: Rausch Christian , Rothenberg-Thurley Maja , Dufour Annika , Schneider Stephanie , Gittinger Hanna , Sauerland Cristina , Görlich Dennis , Krug Utz , Berdel Wolfgang E. , Woermann Bernhard J. , Hiddemann Wolfgang , Braess Jan , von Bergwelt-Baildon Michael , Spiekermann Karsten , Herold Tobias , Metzeler Klaus H.
Published: April 2023

The revised 2022 European LeukemiaNet (ELN) AML risk stratification system requires validation in large, homogeneously treated cohorts. We studied 1118 newly diagnosed AML patients (median age, 58 years; range, 18–86 years) who received cytarabine-based induction chemotherapy between 1999 and 2012 and compared ELN-2022 to the previous ELN-2017 risk classification. Key findings were validated in a cohort of 1160 mostly younger patients. ELN-2022 reclassified 15% of patients, 3% into more favorable, and 12% into more adverse risk groups. This was mainly driven by patients reclassified from intermediate- to adverse-risk based on additional myelodysplasia-related mutations being included as adverse-risk markers. These patients (n = 79) had significantly better outcomes than patients with other adverse-risk genotypes (5-year OS, 26% vs. 12%) and resembled the remaining intermediate-risk group. Overall, time-dependent ROC curves and Harrel’s C-index controlling for age, sex, and AML type (de novo vs. sAML/tAML) show slightly worse prognostic discrimination of ELN-2022 compared to ELN-2017 for OS. Further refinement of ELN-2022 without including additional genetic markers is possible, in particular by recognizing TP53-mutated patients with complex karyotypes as “very adverse”. In summary, the ELN-2022 risk classification identifies a larger group of adverse-risk patients at the cost of slightly reduced prognostic accuracy compared to ELN-2017.
Unveiling the complexity of spatiotemporal soliton molecules in real time
Authors: Guo Yuankai , Lin Wei , Wang Wenlong , Zhang Runsen , Liu Tao , Xu Yiqing , Wei Xiaoming , Yang Zhongmin
Published: April 2023

Observing the dynamics of 3D soliton molecules can hold great opportunities for unveiling the mechanism of molecular complexity and other nonlinear problems. In spite of this fantastic potential, real-time visualization of their dynamics occurring on femtosecond-to-picosecond time scales is still challenging, particularly when high-spatiotemporal-resolution and long-term observation are required. In this work, we observe the real-time speckle-resolved spectral-temporal dynamics of 3D soliton molecules for a long time interval using multispeckle spectral-temporal measurement technology. Diverse real-time dynamics of 3D soliton molecules are captured for the first time, including the speckle-resolved birth, spatiotemporal interaction, and internal vibration of 3D soliton molecules. Further studies show that nonlinear spatiotemporal coupling associated with a large average-chirp gradient over the speckled mode profile plays a significant role in these dynamics. These efforts may shed new light on decomposing the complexity of 3D soliton molecules, and create an analogy between 3D soliton molecules and chemical molecules.
A bacterial autotransporter impairs innate immune responses by targeting the transcription factor TFE3
Authors: Ta Atri , Ricci-Azevedo Rafael , Vasudevan Swathy O. , Wright Skylar S. , Kumari Puja , Havira Morena S. , Surendran Nair Meera , Rathinam Vijay A. , Vanaja Sivapriya Kailasan
Published: April 2023

Type I interferons (IFNs) are consequential cytokines in antibacterial defense. Whether and how bacterial pathogens inhibit innate immune receptor-driven type I IFN expression remains mostly unknown. By screening a library of enterohemorrhagic Escherichia coli (EHEC) mutants, we uncovered EhaF, an uncharacterized protein, as an inhibitor of innate immune responses including IFNs. Further analyses identified EhaF as a secreted autotransporter—a type of bacterial secretion system with no known innate immune-modulatory function—that translocates into host cell cytosol and inhibit IFN response to EHEC. Mechanistically, EhaF interacts with and inhibits the MiT/TFE family transcription factor TFE3 resulting in impaired TANK phosphorylation and consequently, reduced IRF3 activation and type I IFN expression. Notably, EhaF-mediated innate immune suppression promotes EHEC colonization and pathogenesis in vivo. Overall, this study has uncovered a previously unknown autotransporter-based bacterial strategy that targets a specific transcription factor to subvert innate host defense.
Targeting advanced prostate cancer with STEAP1 chimeric antigen receptor T cell and tumor-localized IL-12 immunotherapy
Authors: Bhatia Vipul , Kamat Nikhil V. , Pariva Tiffany E. , Wu Li-Ting , Tsao Annabelle , Sasaki Koichi , Sun Huiyun , Javier Gerardo , Nutt Sam , Coleman Ilsa , Hitchcock Lauren , Zhang Ailin , Rudoy Dmytro , Gulati Roman , Patel Radhika A. , Roudier Martine P. , True Lawrence D. , Srivastava Shivani , Morrissey Colm M. , Haffner Michael C. , Nelson Peter S. , Priceman Saul J. , Ishihara Jun , Lee John K.
Published: April 2023

Six transmembrane epithelial antigen of the prostate 1 (STEAP1) is a cell surface antigen for therapeutic targeting in prostate cancer. Here, we report broad expression of STEAP1 relative to prostate-specific membrane antigen (PSMA) in lethal metastatic prostate cancers and the development of a STEAP1-directed chimeric antigen receptor (CAR) T cell therapy. STEAP1 CAR T cells demonstrate reactivity in low antigen density, antitumor activity across metastatic prostate cancer models, and safety in a human STEAP1 knock-in mouse model. STEAP1 antigen escape is a recurrent mechanism of treatment resistance and is associated with diminished tumor antigen processing and presentation. The application of tumor-localized interleukin-12 (IL-12) therapy in the form of a collagen binding domain (CBD)-IL-12 fusion protein combined with STEAP1 CAR T cell therapy enhances antitumor efficacy by remodeling the immunologically cold tumor microenvironment of prostate cancer and combating STEAP1 antigen escape through the engagement of host immunity and epitope spreading.
Greater traditionalism predicts COVID-19 precautionary behaviors across 27 societies
Authors: Samore Theodore , Fessler Daniel M. T. , Sparks Adam Maxwell , Holbrook Colin , Aarøe Lene , Baeza Carmen Gloria , Barbato María Teresa , Barclay Pat , Berniūnas Renatas , Contreras-Garduño Jorge , Costa-Neves Bernardo , del Pilar Grazioso Maria , Elmas Pınar , Fedor Peter , Fernandez Ana Maria , Fernández-Morales Regina , Garcia-Marques Leonel , Giraldo-Perez Paulina , Gul Pelin , Habacht Fanny , Hasan Youssef , Hernandez Earl John , Jarmakowski Tomasz , Kamble Shanmukh , Kameda Tatsuya , Kim Bia , Kupfer Tom R. , Kurita Maho , Li Norman P. , Lu Junsong , Luberti Francesca R. , Maegli María Andrée , Mejia Marinés , Morvinski Coby , Naito Aoi , Ng’ang’a Alice , de Oliveira Angélica Nascimento , Posner Daniel N. , Prokop Pavol , Shani Yaniv , Solorzano Walter Omar Paniagua , Stieger Stefan , Suryani Angela Oktavia , Tan Lynn K. L. , Tybur Joshua M. , Viciana Hugo , Visine Amandine , Wang Jin , Wang Xiao-Tian
Published: April 2023

People vary both in their embrace of their society’s traditions, and in their perception of hazards as salient and necessitating a response. Over evolutionary time, traditions have offered avenues for addressing hazards, plausibly resulting in linkages between orientations toward tradition and orientations toward danger. Emerging research documents connections between traditionalism and threat responsivity, including pathogen-avoidance motivations. Additionally, because hazard-mitigating behaviors can conflict with competing priorities, associations between traditionalism and pathogen avoidance may hinge on contextually contingent tradeoffs. The COVID-19 pandemic provides a real-world test of the posited relationship between traditionalism and hazard avoidance. Across 27 societies (N = 7844), we find that, in a majority of countries, individuals’ endorsement of tradition positively correlates with their adherence to costly COVID-19-avoidance behaviors; accounting for some of the conflicts that arise between public health precautions and other objectives further strengthens this evidence that traditionalism is associated with greater attention to hazards.
Neuronal growth on high-aspect-ratio diamond nanopillar arrays for biosensing applications
Authors: Losero Elena , Jagannath Somanath , Pezzoli Maurizio , Goblot Valentin , Babashah Hossein , Lashuel Hilal A. , Galland Christophe , Quack Niels
Published: April 2023

Monitoring neuronal activity with simultaneously high spatial and temporal resolution in living cell cultures is crucial to advance understanding of the development and functioning of our brain, and to gain further insights in the origin of brain disorders. While it has been demonstrated that the quantum sensing capabilities of nitrogen-vacancy (NV) centers in diamond allow real time detection of action potentials from large neurons in marine invertebrates, quantum monitoring of mammalian neurons (presenting much smaller dimensions and thus producing much lower signal and requiring higher spatial resolution) has hitherto remained elusive. In this context, diamond nanostructuring can offer the opportunity to boost the diamond platform sensitivity to the required level. However, a comprehensive analysis of the impact of a nanostructured diamond surface on the neuronal viability and growth was lacking. Here, we pattern a single crystal diamond surface with large-scale nanopillar arrays and we successfully demonstrate growth of a network of living and functional primary mouse hippocampal neurons on it. Our study on geometrical parameters reveals preferential growth along the nanopillar grid axes with excellent physical contact between cell membrane and nanopillar apex. Our results suggest that neuron growth can be tailored on diamond nanopillars to realize a nanophotonic quantum sensing platform for wide-field and label-free neuronal activity recording with sub-cellular resolution.
Disentangling diagnostic object properties for human scene categorization
Authors: Wiesmann Sandro L. , Võ Melissa L.-H.
Published: April 2023

It usually only takes a single glance to categorize our environment into different scene categories (e.g. a kitchen or a highway). Object information has been suggested to play a crucial role in this process, and some proposals even claim that the recognition of a single object can be sufficient to categorize the scene around it. Here, we tested this claim in four behavioural experiments by having participants categorize real-world scene photographs that were reduced to a single, cut-out object. We show that single objects can indeed be sufficient for correct scene categorization and that scene category information can be extracted within 50 ms of object presentation. Furthermore, we identified object frequency and specificity for the target scene category as the most important object properties for human scene categorization. Interestingly, despite the statistical definition of specificity and frequency, human ratings of these properties were better predictors of scene categorization behaviour than more objective statistics derived from databases of labelled real-world images. Taken together, our findings support a central role of object information during human scene categorization, showing that single objects can be indicative of a scene category if they are assumed to frequently and exclusively occur in a certain environment.
Morphological and organic spectroscopic studies of a 44-million-year-old leaf beetle (Coleoptera: Chrysomelidae) in amber with endogenous remains of chitin
Authors: Mitchell Jerit L. , McKellar Ryan C. , Barbi Mauricio , Coulson Ian M. , Bukejs Andris
Published: April 2023

This study details the quality of preservation of amber deposits in the Eocene. Through Baltic amber crack-out studies using Synchrotron Micro-Computed Tomography and Scanning Electron Microscopy it was found that the cuticle of a specimen of leaf beetle (Crepidodera tertiotertiaria (Alticini: Galerucinae: Chrysomelidae)) is exceptionally well preserved. Spectroscopic analysis using Synchrotron Fourier Transform Infrared Spectroscopy suggests presence of degraded $$\upalpha$$
α
-chitin in multiple areas of the cuticle, and Energy Dispersive Spectroscopy supports the presence of organic preservation. This remarkable preservation is likely the result of several factors such as the favourable antimicrobial and physical shielding properties of Baltic amber as compared to other depositional media, coupled to rapid dehydration of the beetle early in its taphonomic process. We provide evidence that crack-out studies of amber inclusions, although inherently destructive of fossils, are an underutilised method for probing exceptional preservation in deep time.
Conservative management of early-stage endometrial cancer for fertility preservation: a survey study among Swedish gynecologists and gynecological oncologists
Authors: Iliadis Stavros I. , Gambadauro Pietro
Published: April 2023

Conservative management of endometrial cancer (CMEC) is viable for women with early-stage disease wishing to preserve fertility, but there is poor knowledge regarding clinicians’ attitudes towards treatment or guidelines adherence. This 55-item survey study investigated CMEC-related experience, practice and attitudes among clinically active Swedish gynecologists and gynecological oncologists, focusing on reproductive eligibility criteria. The survey consisted of a general and two specific subsets, selectively delivered to clinicians active in infertility (subset A) and endometrial cancer (subset B) care. Answers from 218 clinicians were included. More than half agreed on CMEC whereas only 5% explicitly disagreed. The majority supported a fertility work-up to substantiate reasonable chances to pregnancy and live birth. Most disagreed about CMEC in case of previous unsuccessful fertility treatments, while more than 1/3 disagreed about CMEC in known fertility problems, recurrent miscarriages or previous children. Over 50% of respondents in subset A (n = 107) found it applicable with fertility investigations such as ovarian reserve testing or, in case of male partner, semen analysis. Respondents in subset B (n = 165) agreed on items based on existing recommendations regarding the oncological management of CMEC, including the use of continuous progestins, hysteroscopic resection of macroscopic lesions, control biopsy with curettage or hysteroscopy after 6 months of treatment, pursuing pregnancy as soon as possible after complete response, and performing a hysterectomy once live birth is achieved. While many clinicians were familiar with CMEC, the overall experience is limited. Fertility specialists seem less involved than oncologists in patient care but there is broad support for fertility-related eligibility criteria.
Screening of single nucleotide polymorphisms within HLA region related to hematopoietic stem cell transplantation using MassARRAY technology
Authors: Tsai Shu-Hui , Chang Pi-Yueh , Wen Ying-Hao , Lin Wei-Tzu , Hsu Fang-Ping , Chen Ding-Ping
Published: April 2023

A growing number of studies showed that single nucleotide polymorphisms (SNPs) in the human leukocyte antigen (HLA)-related genes were associated with the outcome of hematopoietic stem cell transplantation (HSCT). Thus, other SNPs located nearby the classical HLA genes must be considered in HSCT. We evaluated the clinical feasibility of MassARRAY by comparing to Sanger sequencing. The PCR amplicons with each one of the 17 loci that were related to the outcomes of HSCT published by our previous study were transferred onto a SpectroCHIP Array for genotyping by mass spectrometry. The sensitivity of MassARRAY was 97.9% (614/627) and the specificity was 100% (1281/1281), where the positive predictive value (PPV) was 100% (614/614) and the negative predictive value (NPV) was 99.0% (1281/1294). MassARRAY is high-throughput, which can accurately analyze multiple SNPs at the same time. Based on these properties, we proposed that it could be an efficient method to match the genotype between the graft and the recipient before transplantation.
Proteomics reveals specific biological changes induced by the normothermic machine perfusion of donor kidneys with a significant up-regulation of Latexin
Authors: Zaza Gianluigi , Neri Flavia , Bruschi Maurizio , Granata Simona , Petretto Andrea , Bartolucci Martina , di Bella Caterina , Candiano Giovanni , Stallone Giovanni , Gesualdo Loreto , Furian Lucrezia
Published: April 2023

Renal normothermic machine perfusion (NMP) is an organ preservation method based on the circulation of a warm (35–37 °C) perfusion solution through the renal vasculature to deliver oxygen and nutrients. However, its biological effects on marginal kidneys are unclear. We therefore used mass spectrometry to determine the proteomic profile of kidney tissue and urine from eight organs reconditioned for 120 min using a Kidney Assist device. Biopsies were taken during the pre-implantation histological evaluation (T-1), at the start of back table preparation (T0), and after 60 and 120 min of perfusion (T60, T120). Urine samples were collected at T0 (urine produced in the first 15 min after the beginning of normothermic reperfusion), T30, T60 and T120. Multiple algorithms, support vector machine learning and partial least squares discriminant analysis were used to select the most discriminative proteins during NMP. Statistical analysis revealed the upregulation of 169 proteins and the downregulation of 196 during NMP. Machine learning algorithms identified the top 50 most discriminative proteins, five of which were concomitantly upregulated (LXN, ETFB, NUDT3, CYCS and UQCRC1) and six downregulated (CFHR3, C1S, CFI, KNG1, SERPINC1 and F9) in the kidney and urine after NMP. Latexin (LXN), an endogenous carboxypeptidase inhibitor, resulted the most-upregulated protein at T120, and this result was confirmed by ELISA. In addition, functional analysis revealed that the most strongly upregulated proteins were involved in the oxidative phosphorylation system and ATP synthesis, whereas the downregulated proteins represented the complement system and coagulation cascade. Our proteomic analysis demonstrated that even brief periods of NMP induce remarkable metabolic and biochemical changes in marginal organs, which supports the use of this promising technique in the clinic.
Complete response to alectinib in ALK-fusion metastatic salivary ductal carcinoma
Authors: Adashek Jacob J. , Sapkota Surendra , de Castro Luna Rodrigo , Seiwert Tanguy Y.
Published: April 2023

The advent of next-generation sequencing (NGS) has allowed for the identification of novel therapeutic targets for patients with uncommon cancers. It is well known that fusion translocations are potent driver of cancer pathogenesis and can render tumors exquisitely sensitive to matching targeted therapies. Here we describe a patient with ALK-fusion positive widely metastatic salivary ductal carcinoma, who achieved a durable complete response from alectinib, a potent and specific ALK tyrosine kinase inhibitor. This case serves as another reminder that ALK-fusions can be targeted regardless of histology and can afford patients dramatic and durable benefit. It also emphasizes the need for insurance coverage for such beneficial therapies. While ALK fusions are exceedingly rare in salivary ductal carcinoma, the presence of multiple other targetable aberrations supports the recommendation for universal NGS testing for such tumors.
Reprogramming of human peripheral blood mononuclear cells into induced mesenchymal stromal cells using non-integrating vectors
Authors: Chen Wanqiu , Wang Chenguang , Yang Zhi-Xue , Zhang Feng , Wen Wei , Schaniel Christoph , Mi Xianqiang , Bock Matthew , Zhang Xiao-Bing , Qiu Hongyu , Wang Charles
Published: April 2023

Mesenchymal stromal cells (MSCs) have great value in cell therapies. The MSC therapies have many challenges due to its inconsistent potency and limited quantity. Here, we report a strategy to generate induced MSCs (iMSCs) by directly reprogramming human peripheral blood mononuclear cells (PBMCs) with OCT4, SOX9, MYC, KLF4, and BCL-XL using a nonintegrating episomal vector system. While OCT4 was not required to reprogram PBMCs into iMSCs, omission of OCT4 significantly impaired iMSC functionality. The omission of OCT4 resulted in significantly downregulating MSC lineage specific and mesoderm-regulating genes, including SRPX, COL5A1, SOX4, SALL4, TWIST1. When reprogramming PBMCs in the absence of OCT4, 67 genes were significantly hypermethylated with reduced transcriptional expression. These data indicate that transient expression of OCT4 may serve as a universal reprogramming factor by increasing chromatin accessibility and promoting demethylation. Our findings represent an approach to produce functional MSCs, and aid in identifying putative function associated MSC markers.
Fungi-enabled hierarchical porous magnetic carbon derived from biomass for efficient remediation of As(iii)-contaminated water and soil: performance and mechanism
Authors: Jin Qian , Cui Jianghu
Published: April 2023

In this study, fungi-enabled hierarchical porous magnetic carbon (FPC/nZVI) with an ultrahigh surface area was synthesized using fungal fermentation and used for the efficient remediation of As(iii) in water and soil.
Imidazole-based artificial synapses for neuromorphic computing: a cluster-type conductive filament via controllable nanocluster nucleation
Authors: Oh Jungyeop , Yang Sang Yoon , Kim Sungkyu , Lee Changhyeon , Cha Jun-Hwe , Jang Byung Chul , Im Sung Gap , Choi Sung-Yool
Published: April 2023

Neuromorphic systems, conducting bridging random-access memory, initiated chemical vapor deposition, copolymerization, deep neural networks, and artificial synapses.
Improving the activity of horseradish peroxidase in betaine-based natural deep eutectic systems
Authors: Meneses Liane , Gajardo-Parra Nicolás F. , Cea-Klapp Esteban , Garrido José Matías , Held Christoph , Duarte Ana Rita , Paiva Alexandre
Published: April 2023

In this work, the activity and thermostability of horseradish peroxidase (HRP) in betaine-based natural deep eutectic systems (NADESs) was measured and studied by molecular simulations.
Insights into the deactivation mechanism of a self-supported nickel electrode for 5-hydroxymethyl furfural electrooxidation: focus on the stability of the electrode as a whole
Authors: Liu Fangbing , Lin Nan , Xin Deyuan , Li Xinxin , Cong Linchuan , Han Fuyu , Lin Haibo
Published: April 2023

Three routes were proposed based on the structure of a self-supported NiOx loaded nickel foam electrode under operating conditions, which are: catalytically active layer shedding, nickel matrix dissolution, and the accelerated shedding effect of OER.
Computational screening of two-dimensional metal-benzenehexathial for the oxygen reduction reaction
Authors: Wei Shuya , Zhou Xiaocheng , Wang Yu , Li Yafei
Published: April 2023

Two-dimensional metal-benzenehexathial sheets are promising catalysts for the oxygen reduction reaction.
Metal–organic framework clustering through the lens of transfer learning
Authors: Cooper Gregory M. , Colón Yamil J.
Published: April 2023

Transfer learning performance across the textural space of metal–organic frameworks depends on the distance in principal component space.
Hyaluronidase-trigger nanocarriers for targeted delivery of anti-liver cancer compound
Authors: Xu Junxin , Chen Siling , Yang Jianmei , Nie Zhengquan , He Junnan , Zhao Yong , Liu Xiaoqing , Zhang Jin , Zhao Yan
Published: April 2023

HA/(MI)7-β-CD NCs exhibits HA receptor-mediated targeting and disassembly properties under HAase stimulation, which was utilized to trap, targeted deliver and controlled release of anti-liver cancer compound CSL.
Aptamer modified Zr-based porphyrinic nanoscale metal–organic frameworks for active-targeted chemo-photodynamic therapy of tumors
Authors: Feng Haidi , Zhao Lu , Bai Zhiqiang , Xin Zhihui , Wang Chaoyu , Liu Lizhen , Song Jinping , Zhang Haifei , Bai Yunfeng , Feng Feng
Published: April 2023

In this work, an aptamer MUC1 modified nanoplatform DOX@PCN@Apt-M was proposed for tumor active-targeted chemo-photodynamic therapy.
Theoretical insights into the amplified optical gain of hexagonal germanium by strain engineering
Authors: Mayengbam Rishikanta , Tan Chuan Seng , Fan Weijun
Published: April 2023

Effect of strain on the light emission nature of hexagonal germanium studied using DFT. Increase in amplification and bandwidth of optical gain observed due to increased electron concentration in Γ−7c state and enhanced momentum matrix.
Toxic effects and bioaccumulation of pinacolyl methylphosphonate acid in zebrafish following soman exposure to a water environment
Authors: Zong Xing-Xing , Cao Niannian , Jing Qian , Chen Xuejun , Shi Tong , Zhang Ruihua , Shi Jingjing , Wang Chen , Li Liqin
Published: April 2023

Pinacolyl methylphosphonate acid bioaccumulation in zebrafish could be the reason for zebrafish dyskinesia and histopathologic lesions observed following soman exposure.
Fully stretchable textile-based triboelectric nanogenerators with crepe-paper-induced surface microstructures
Authors: Kim Da Eun , Shin Siho , Zhang Gengjia , Choi Daegil , Jung Jaehyo
Published: April 2023

Several studies have been conducted on textile-based TENGs (T-TENGs) with high performance and wearability, which can efficiently harvest energy based on human body motions. STENG is a self-powered device capable of supplying power to small and portable electronic devices.
Scalable synthesis of soluble crystalline ionic-graphdiyne by controlled ion expansion
Authors: Wang Lingling , Qi Lu , Zhang Qinglei , Xue Binghui , Zheng Zhiqiang , Yin Panchao , Xue Yurui , Yang Wenlong , Li Yuliang
Published: April 2023

A highly soluble, interlayer-expanded, and crystalline ionic graphdiyne was obtained through “framework charge-induced intercalation (FCII)” strategy.
Interlayer modification and single-layer exfoliation of the Ruddlesden–Popper perovskite oxynitride K2LaTa2O6N to improve photocatalytic H2 evolution activity
Authors: Shiroma Yuta , Mogi Hiroto , Mashiko Takeaki , Yasuda Shuhei , Nishioka Shunta , Yokoi Toshiyuki , Ida Shintaro , Kimoto Koji , Maeda Kazuhiko
Published: April 2023

Ethylamine-intercalated HxK2−xLaTa2O6N, further modified with a Pt cocatalyst, exhibited 60 times height photocatalytic activity for H2 evolution under visible light, as compared with the parent layered material.
Automatic textual description of colorectal polyp features: explainable artificial intelligence
Authors: Thijssen Ayla , Schreuder Ramon-Michel , Fonollà Roger , van der Zander Quirine , Scheeve Thom , Winkens Bjorn , Subramaniam Sharmila , Bhandari Pradeep , de With Peter , Masclee Ad , van der Sommen Fons , Schoon Erik
Published: April 2023

Computer-aided diagnosis systems (CADx) can improve colorectal polyp (CRP) optical diagnosis. For integration into clinical practice, better understanding of artificial intelligence (AI) by endoscopists is needed. We aimed to develop an explainable AI CADx capable of automatically generating textual descriptions of CRPs. For training and testing of this CADx, textual descriptions of CRP size and features according to the Blue Light Imaging (BLI) Adenoma Serrated International Classification (BASIC) were used, describing CRP surface, pit pattern, and vessels. CADx was tested using BLI images of 55 CRPs. Reference descriptions with agreement by at least five out of six expert endoscopists were used as gold standard. CADx performance was analyzed by calculating agreement between the CADx generated descriptions and reference descriptions. CADx development for automatic textual description of CRP features succeeded. Gwet’s AC1 values comparing the reference and generated descriptions per CRP feature were: size 0.496, surface-mucus 0.930, surface-regularity 0.926, surface-depression 0.940, pits-features 0.921, pits-type 0.957, pits-distribution 0.167, and vessels 0.778. CADx performance differed per CRP feature and was particularly high for surface descriptors while size and pits-distribution description need improvement. Explainable AI can help comprehend reasoning behind CADx diagnoses and therefore facilitate integration into clinical practice and increase trust in AI.
Cerebrospinal Fluid Leakage from Scrotum Secondary to Ventriculoperitoneal Shunt Migration
Authors: Topp Gregory , Entezami Pouya , Ambati Shashikanth , Szewczyk Benjamin , Adamo Matthew A.
Published: April 2023

Ventriculoperitoneal (VP) shunts are a common neurosurgical procedure used to treat hydrocephalus. Despite their efficacy, many shunts fail and require revisions. The most common causes of shunt failure include obstruction, infection, migration, and perforation. Extraperitoneal migrations require urgent attention. We present a case of migration to the scrotum, a unique complication that may be present in young patients due to the presence of a patent processus vaginalis. Here, we discuss a case of a 16-month-old male patient with a VP shunt presenting with cerebrospinal fluid (CSF) drainage from his scrotum after an indirect hernia repair. This case represents an important reminder for physicians about the sequelae associated with VP shunt complications, particularly extraperitoneal migration, and brings awareness to the underlying factors that may increase this risk.
Influence of motivation on teachers’ job performance
Authors: kumari Joti , Kumar Jai
Published: April 2023

Motivation is the key to success in educational institutions, and it empowers a teacher to work with an affection that contributes to the accomplishment of hierarchical objectives. Yet, what drives school teachers to be pleased or motivated to achieve exceptional performance? This contemplation must be considered thoroughly in different regions with different predictors. Therefore, this study aims to identify the factors influencing teachers’ motivation and evaluate the influence of motivation on teachers’ job performance in private schools in Mirpurkhas, Pakistan. We use quantitative statistics and a partial least-squares structural equation modeling (PLS-SEM analysis) design; the data was collected through a survey questionnaire. We found that motivation significantly influences teachers’ job performance. The study revealed that self-determined and non-self-determined motivation and factors influencing teachers’ motivation significantly impact teachers’ job performance. The administration must formulate teachers’ motivational policies and practices to meet their needs. Furthermore, school administrations should provide adequate resources like bonuses, rewards, good communication, moral support, emotional support, and an increment in salaries to ensure quality learning and yield high performance from their teaching staff to improve the relevant education system.
Deep learning of nonlinear flame fronts development due to Darrieus–Landau instability
Authors: Yu Rixin
Published: April 2023

The Darrieus–Landau instability is studied using a data-driven, deep neural network approach. The task is set up to learn a time-advancement operator mapping any given flame front to a future time. A recurrent application of such an operator rolls out a long sequence of predicted flame fronts, and a learned operator is required to not only make accurate short-term predictions but also reproduce characteristic nonlinear behavior, such as fractal front structures and detached flame pockets. Using two datasets of flame front solutions obtained from a heavy-duty direct numerical simulation and a light-duty modeling equation, we compare the performance of three state-of-art operator-regression network methods: convolutional neural networks, Fourier neural operator (FNO), and deep operator network. We show that, for learning complicated front evolution, FNO gives the best recurrent predictions in both the short and long term. A consistent extension allowing the operator-regression networks to handle complicated flame front shape is achieved by representing the latter as an implicit curve.
The toad less travelled: comparing life histories, ecological niches, and potential habitat of Asian black-spined toads and cane toads
Authors: Kelly C. L. , Schwarzkopf L. , Christy T. M. , Kennedy M. S.
Published: April 2023

Context Invasive vertebrates have significant negative impacts on biodiversity and agricultural production worldwide. Increased connectivity among countries, through trade and tourism, is escalating the rate of introductions of vertebrate species, particularly herpetofauna, across international borders. In Australia, Asian black-spined toads (ABSTs; Duttaphrynus melanostictus) are one of the species most intercepted at borders. They are considered a biosecurity risk because of the potential for negative environmental impacts, similar to those caused by cane toads (Rhinella marina). Aims We aimed to compare ABSTs with cane toads to investigate potential impacts and distribution of ABSTs in the Australian context. We also aimed to identify knowledge gaps regarding ABST biology and the potential role of cane toads in an ABST invasion in Australia. Methods We undertook a literature review to obtain published data to compare the life history characteristics of ABSTs and cane toads. We also modelled climatic niche overlap and compared suitable habitat for both species in Australia. Key results Our results show ABSTs and cane toads have broadly similar reproductive life histories and feeding niches. In particular, similarities include large clutch sizes, preferred oviposition sites, and diet at tadpole and adult life stages. In Australia, the species share suitable potential habitat, particularly in North Queensland, where the majority of ABST incursions have occurred. The species differ in size, call characteristics, clutch size relative to body size, and egg development rate, although the environment also influences these traits. We identify gaps in our knowledge of ABST spatial ecology, thermal tolerances, water reliance, and habitat. Conclusions ABSTs pose a significant biosecurity threat to Australia. Similarities in life history to cane toads means they may have similar impacts, but may have a more limited distribution in Australia. Invasion of Australia by ABSTs would likely result in interactions with cane toads, but it is not possible to accurately determine the outcomes of those interactions without further investigation. Implications Addressing knowledge gaps and quantitatively determining the potential for competition between ABSTs and cane toads will assist surveillance and response planning for ABST incursions in Australia.
Is linguistic decision-making constrained by the same cognitive factors in student and in professional
translation?
Authors: De Sutter Gert , Lefer Marie-Aude , Vanroy Bram
Published: April 2023

This article analyses the extent to which four well-known general cognitive constraints – syntactic priming,
cognitive routinisation, markedness of coding and structural integration – impact the linguistic output of translation students
and professional translators similarly. It takes subject placement variation in Dutch as a test case to gauge the effect of the
four constraints and relies on a controlled corpus of student and professional French-to-Dutch L1 news translations, from which
all declarative main clauses with either a preverbal or a postverbal subject were extracted. All corpus instances were annotated
for four random variables, the fixed variable expertise and ten other fixed variables, which were considered good proxies
for the cognitive constraints. A mixed-effects regression analysis reveals that by and large the cognitive constraints have an
identical effect on student and professional translators’ output, with priming and structural integration having the strongest
impact on subject placement. However, students diverge from professionals when translating French clauses with a left-dislocated
adjunct into Dutch, which is interpreted as an indication of a difference in automatisation when dealing with specific
French-Dutch cross-linguistic differences.
La construction < DÉT poss. 1re pers. sing. + N évoquant le divin
>
Authors: Dostie Gaétane
Published: April 2023

Cet article porte sur quatre locutions, à savoir mon dieu, mon doux, ma foi et my
god. Leur similarité de forme et leur appartenance à un même paradigme sémantique amènent à se questionner sur leur
éventuelle équivalence sémantique et fonctionnelle dans les interactions verbales à l’oral. Pour répondre à cette question, un
examen attentif des collocations propres aux locutions à l’étude est entrepris. Deux propositions sont formulées. D’une part, il y
aurait une opposition claire entre les sens exprimés et les fonctions assumées par les locutions selon leur visée (rétrospective
avec mon dieu, mon doux et my god et prospective avec ma foi). D’autre part,
il y aurait une symétrie sémantique et fonctionnelle parfaite entre deux des locutions qui ont une visée rétrospective, à savoir
mon dieu et mon doux en français québécois, et un rapprochement net entre ces deux
dernières et my god.