Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma
Authors: Bernatsky Sasha , Velásquez García Héctor A , Spinelli John J , Gaffney Patrick , Smedby Karin E , Ramsey-Goldman Rosalind , Wang Sophia S , Adami Hans-Olov , Albanes Demetrius , Angelucci Emanuele , Ansell Stephen M , Asmann Yan W , Becker Nikolaus , Benavente Yolanda , Berndt Sonja I , Bertrand Kimberly A , Birmann Brenda M , Boeing Heiner , Boffetta Paolo , Bracci Paige M , Brennan Paul , Brooks-Wilson Angela R , Cerhan James R , Chanock Stephen J , Clavel Jacqueline , Conde Lucia , Cotenbader Karen H , Cox David G , Cozen Wendy , Crouch Simon , De Roos Anneclaire J , de Sanjose Silvia , Di Lollo Simonetta , Diver W Ryan , Dogan Ahmet , Foretova Lenka , Ghesquières Hervé , Giles Graham G , Glimelius Bengt , Habermann Thomas M , Haioun Corinne , Hartge Patricia , Hjalgrim Henrik , Holford Theodore R , Holly Elizabeth A , Jackson Rebecca D , Kaaks Rudolph , Kane Eleanor , Kelly Rachel S , Klein Robert J , Kraft Peter , Kricker Anne , Lan Qing , Lawrence Charles , Liebow Mark , Lightfoot Tracy , Link Brian K , Maynadie Marc , McKay James , Melbye Mads , Molina Thierry J , Monnereau Alain , Morton Lindsay M , Nieters Alexandra , North Kari E , Novak Anne J , Offit Kenneth , Purdue Mark P , Rais Marco , Riby Jacques , Roman Eve , Rothman Nathaniel , Salles Gilles , Severi Gianluca , Severson Richard K , Skibola Christine F , Slager Susan L , Smith Alex , Smith Martyn T , Southey Melissa C , Staines Anthony , Teras Lauren R , Thompson Carrie A , Tilly Hervé , Tinker Lesley F , Tjonneland Anne , Turner Jenny , Vajdic Claire M , Vermeulen Roel C H , Vijai Joseph , Vineis Paolo , Virtamo Jarmo , Wang Zhaoming , Weinstein Stephanie , Witzig Thomas E , Zelenetz Andrew , Zeleniuch-Jacquotte Anne , Zhang Yawei , Zheng Tongzhang , Zucca Mariagrazia , Clarke Ann E 
Published: November 2017

Objective

Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL.

Methods

GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis.

Results

Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765.

Conclusions

These data suggest several plausible genetic links between DLBCL and SLE.