bluuebunny/crossref_metadata_2025 huggingface dataset:
Economic, environmental, and social sustainability of Alternate Wetting and Drying irrigation for rice in northern Italy
Authors: Gharsallah Olfa , Rienzner Michele , Mayer Alice , Tkachenko Darya , Corsi Stefano , Vuciterna Rina , Romani Marco , Ricciardelli Andrea , Cadei Elisa , Trevisan Marco , Lamastra Lucrezia , Tediosi Alice , Voccia Diego , Facchi Arianna
Published: July 2023

Italy is Europe's leading rice producer, with over half of total production almost totally concentrated in the north-western part of the Padana plain. In this area, rice irrigation has traditionally been carried out by wet seeding and continuous flooding. The replacement of this technique with the dry seeding and delayed flooding in the last 15 years brought economic benefits to farmers but also strong impacts to the water resource system of the area, characterized by a strong interaction between irrigation and shallow aquifer levels. Wet seeding and Alternate Wetting and Drying (AWD) could be seen as an alternative irrigation strategy; however, its environmental, economic and social sustainability must be investigated before supporting the dissemination of this “water-saving” irrigation technique over the territory in cooperation with decision-makers and water resource managers. In this paper, the results of an experimental activity carried out in a platform established in the main Italian rice district to compare three irrigation strategies (wet seeding and traditional flooding—WFL, dry seeding and delayed flooding from around the 3-leaf stage—DFL, wet seeding and alternated wetting and drying from the tillering stage—AWD) and data further provided by the farm holder (agronomic inputs and economic costs for the three options) were used to assess their economic and environmental sustainability through an assessment procedure based on quantitative indicators. Interviews with rice growers in the area were used to identify barriers to the adoption of AWD and subsequently propose ways to overcome them. AWD proved to be economically viable and to reduce the irrigation need in the peak month (June) without significantly affecting rice yield or quality (cadmium and arsenic content in rice grain). Additionally, it guarantees the recharging of the phreatic aquifer in the first period of the irrigation season, while reducing the methane (CH4) emissions, facing another significant environmental challenge of rice cultivation. Rice growers in the region stated their willingness to adopt AWD, although they would need technical, technological and financial support. The assessment procedure adopted in this paper proved to be effective for comparing rice irrigation techniques and is available for further studies.
Investigating the effect of large solar flares on the ionosphere based on novel Digisonde data comparing three different methods
Authors: Buzás Attila , Kouba Daniel , Mielich Jens , Burešová Dalia , Mošna Zbyšek , Koucká Knížová Petra , Barta Veronika
Published: July 2023

Increased solar radiation during solar flare events can cause additional ionization and enhanced absorption of the electromagnetic (EM) waves in the ionosphere leading to partial or even total radio fade-outs. In this study, the ionospheric response to large solar flares has been investigated using the ionosonde data from Juliusruh (54.63° N, 13.37° E), Průhonice (49.98° N, 14.55° E) and San Vito (40.6° N, 17.8° E) Digisonde (DPS-4D) stations. We studied the effect of 13 intense (>C4.8) solar flares that occurred between 06:00 and 16:30 (UT, daytime LT = UT+1 h) from 04 to 10 September 2017 using three different methods. A novel method based on the amplitude data of the measured EM waves is used to calculate and investigate the relative absorption changes (compared to quiet period) occurring during the flares. The amplitude data are compared with the variation of the fmin parameter (fmin, the minimum measured frequency, it is considered as a qualitative proxy for the “non-deviative” radio wave absorption). Furthermore, the signal-to-noise ratio (SNR) measured by the Digisondes was used as well to quantify and characterize the fade-out events and the ionospheric absorption. In order to compare the three different methods, residuals have been defined for all parameters, which provide the percentage changes compared to the selected reference periods. Total and partial radio fade-outs, increased values (+0.4%–318%) of the fmin parameter, and +20%–1400% amplitude changes (measured at 2.5 and 4 MHz) were experienced during and after the investigated flares. Generally, the observed changes depended on the intensity, solar zenith angle and duration of the flare events. Although the three different methods have their own advantages/disadvantages and their limitations, the combination of them seems to be an efficient approach to monitor the ionospheric response to solar flares.
Urbanization and food security: evidence from Mali
Authors: Macalou Moussa , Keita Sekou I , Coulibaly Adama B. , Diamoutene Abdoul Karim
Published: July 2023

Income poverty remains the main root of urban food insecurity as purchased food represents a major component of the spending of urban residents. The rapid and increasing urbanization and urban sprawl are major concerns for food security in Mali. In Mali, 3.6% of households, are severely food insecure and the food insecurity prevalence rate for urban households is 7.5%. The effect of urbanization on households’ food security was assessed in the literature using only a single measure of food security. In this regard, this study analyzed the effect of urbanization on both objective and subjective measures of food security in Mali, using data from the national survey on food security and nutrition (ENSAN). The data collection was conducted by the Early Warning System against Famine (SAP) on 9,782 households in February 2018. For the objective measure of food security, the study used an OLS model to estimate the effect of urbanization on household food expenditure per capita. Using the household hunger scale (HHS) score, the study estimated two models (logit and ordered probit) to capture the effect of urbanization on subjective measures of food security. The results of the OLS and logit models showed that households living in urban areas are less food secure compared to their counterparts living in rural areas. The results from the ordered probit also confirmed that urban households are more food insecure (mildly and moderately) compared to their counterparts living in rural areas. Based on these results, the study recommends to decision-makers to take into account urban poor households when setting up food safety net programmes.
Research on sustainable development of agricultural product cold chain logistics under public safety emergencies
Authors: He Yuze , Liu Mingfei
Published: July 2023

Under a sudden public security event, as agricultural cold chain logistics has the characteristics of many participating subjects and wide spatial and temporal distribution, it is extremely vulnerable to shocks. Even minor disruptions in logistics can result in a significant impact on the daily lives of residents. Therefore, improving the resilience of agricultural cold-chain logistics is crucial for sustainable development. This paper studies the sustainable development path of agricultural cold chain logistics from a resilience perspective. Through rooting theory, the process of resilience in agricultural cold chain logistics under sudden public safety events is explored. Based on the knowledge meta-model, three elements of resilience events, resilient subjects, and resilience measures are used to contextualize the resilience process, and finally, using Bayesian networks and fuzzy set theory, a contextual derivation model of the resilience process of agricultural cold chain logistics under sudden public safety events is created. The results show that the resilience process of sustainable development consists of a resistance period, an adaptation period, a readjustment period, and an innovation period, during which the government and enterprises jointly take measures to effectively resist the impact of public emergencies, and further enhance the resilience through innovative development to ensure the sustainable development of agricultural cold chain logistics.
Molecular characteristics and zoonotic potential of enteric protists in domestic dogs and cats in Egypt
Authors: Elmahallawy Ehab Kotb , Gareh Ahmed , Abu-Okail Akram , Köster Pamela C. , Dashti Alejandro , Asseri Jamal , Gouda Asmaa Aboelabbas , Mubaraki Murad A. , Mohamed Sara Abdel-Aal , Mohamed Yasser M. , Hassan Ehssan Ahmed , Elgendy Mohamed , Hernández-Castro Carolina , Bailo Begoña , González-Barrio David , Xiao Lihua , Carmena David
Published: July 2023

Introduction

Domestic dogs and cats can be a source of human infection by a wide diversity of zoonotic pathogens including parasites. Genotyping and subtyping tools are useful in assessing the true public health relevance of canine and feline infections by these pathogens. This study investigated the occurrence, genetic diversity, and zoonotic potential of common diarrhea-causing enteric protist parasites in household dogs and cats in Egypt, a country where this information is particularly scarce.

Methods

In this prospective, cross-sectional study a total of 352 individual fecal samples were collected from dogs (n = 218) and cats (n = 134) in three Egyptian governorates (Dakahlia, Gharbeya, and Giza) during July–December 2021. Detection and identification of Cryptosporidium spp., Giardia duodenalis, Enterocytozoon bieneusi, and Blastocystis sp. were carried out by PCR and Sanger sequencing. Basic epidemiological variables (geographical origin, sex, age, and breed) were examined for association with occurrence of infection by enteric protists.

Results and discussion

The overall prevalence rates of Cryptosporidium spp. and G. duodenalis were 1.8% (95% CI: 0.5–4.6) and 38.5% (95% CI: 32.0–45.3), respectively, in dogs, and 6.0% (95% CI: 2.6–11.4) and 32.1% (95% CI: 24.3–40.7), respectively, in cats. All canine and feline fecal samples analyzed tested negative for E. bieneusi and Blastocystis sp. Dogs from Giza governorate and cats from Dakahlia governorate were at higher risk of infection by Cryptosporidium spp. (p = 0.0006) and G. duodenalis (p = 0.00001), respectively. Sequence analyses identified host-adapted Cryptosporidium canis (n = 4, one of them belonging to novel subtype XXe2) and G. duodenalis assemblages C (n = 1) and D (n = 3) in dogs. In cats the zoonotic C. parvum (n = 5) was more prevalent than host-adapted C. felis (n = 1). Household dogs had a limited (but not negligible) role as source of human giardiasis and cryptosporidiosis, but the unexpected high frequency of zoonotic C. parvum in domestic cats might be a public health concern. This is the first molecular-based description of Cryptosporidium spp. infections in cats in the African continent to date. Molecular epidemiological data provided here can assist health authorities and policy makers in designing and implementing effective campaigns to minimize the transmission of enteric protists in Egypt.
Greenhouse Gas Emissions in the Agricultural and Industrial Sectors—Change Trends, Economic Conditions, and Country Classification: Evidence from the European Union
Authors: Murawska Anna , Goryńska-Goldmann Elżbieta
Published: July 2023

The decrease in the level of greenhouse gas (GHG) emissions from industry and agriculture is one of the biggest challenges that European Union (EU) countries have to face. Their economic development should occur under the conditions of limiting the pressure on the environment. The agricultural and industrial sectors play a key role in ensuring food security, technological progress, job security, social well-being, economic competitiveness, and sustainable development. The main purpose of this article was to identify and compare the level, trends, and variability in greenhouse gas emissions from industry and agriculture in EU countries in 2010–2019, to create classes of countries with similar gas emissions, and to analyze the average values of their economic conditions. The original contribution to the article was to investigate whether there is a relationship between the level of greenhouse gas emissions and the economic development of countries and other economic indicators characterizing the sectors of industry and agriculture. Empirical data were obtained from the Eurostat and Ilostat databases. Basic descriptive statistics, classification methods, multiple regression, and correlation methods were used in the study. The industrial and agricultural sectors in EU countries emit similar amounts of greenhouse gases into the environment. In the years 2010–2019, the percentage share of emissions from these sectors in total gas emissions was growing dynamically, but no evidence was found indicating that those countries that emitted the most greenhouse gases significantly reduced their emissions in the decade under review. Moreover, EU countries are still significantly and invariably differentiated in this respect. Greenhouse gas emissions from industry and agriculture are influenced by the economic characteristics of these sectors, such as the level of GDP per capita, the scale of investment by enterprises, the expenditure on research and development, as well as employment in these sectors. The findings of this study show that total greenhouse gas emissions from all sources increase with countries’ economic growth, while a higher level of support of EU countries for research and development, and a greater share of employment in both industry and agriculture, translate into higher greenhouse gas emissions from these sectors. These conclusions may be useful for decision makers in developed and developing countries, as well as those in the industrial and agricultural sectors, in controlling and verifying the possible causes of greenhouse gas emissions in terms of the need to reduce their negative role on the environment and human health.
Effects of a Natural Polyphenolic Product from Olive Mill Wastewater on Oxidative Stress and Post-Weaning Diarrhea in Piglets
Authors: Papakonstantinou Georgios I. , Meletis Eleftherios , Petrotos Konstantinos , Kostoulas Polychronis , Tsekouras Nikolaos , Kantere Maria C. , Voulgarakis Nikolaos , Gougoulis Dimitrios , Filippopoulos Leonidas , Christodoulopoulos Georgios , Athanasiou Labrini V. , Papatsiros Vasileios G.
Published: July 2023

The present study aimed to investigate the effects of a commercial phytogenic feed additive (PFA) on the prevention of post-weaning diarrhea and oxidative stress in piglets. The concentrations of thiobarbituric acid reactive substances (TBARS) and protein carbonyls (CARBS) were investigated as biomarkers for oxidative damage, as were the health and performance parameters of weaned piglets. In total, 100 weaned piglets were divided into two groups: a control group (T1), which was fed regular weaning feed; an experimental group (T2), which was fed regular weaning feed supplemented with a phenolic feed additive (PFA) for 3 weeks. The TBARS and CARBS concentrations in plasma samples from 20 piglets per group were measured at 45 and 65 days of age. Fecal samples were collected from 24 weaned piglets per group using FTA ELUTE cards. Diarrhea score, body weight (BW) at weaning, and average daily weight gain (ADWG) were recorded. The TBARS (p < 0.001) and CARBS (p = 0.001) concentrations were significantly higher in the T1 group compared to those in the T2 group. The lowest diarrhea score was noted in the T2 group for the age groups of 45 (p < 0.001) and 65 days (p = 0.008). In conclusion, the use of a phenolic PFA in the current study had beneficial antioxidative and antimicrobial effects on weaned piglets, which improved their health and growth performance.
Spatial Variability Analysis of Wheat Nitrogen Yield Response: A Case Study of Henan Province, China
Authors: Feng Xiaojie , Li Yixin , Zhao Yanfeng , Chen Jie
Published: July 2023

The overapplication of nitrogen to wheat reduces profits and has adverse environmental consequences. Machine learning techniques are employed to identify the factors that hold the most potential in improving nitrogen recommendations. The database used in our analysis consisted of a formula fertilization project, the second soil census of China, and cultivated land fertility evaluation. The results showed that the wheat nitrogen yield response was mainly concentrated around 1300–2400 kg/ha in Henan Province, with the highest values observed in the southern and eastern regions and the lowest in the northern region. The soil nitrogen content, nitrogen fertilizer, wet nitrogen deposition, dry nitrogen deposition, and soil nitrogen supply capacity were mainly concentrated around 0.65–1.30 g/kg, 173–203 kg N/ha, 15–39 kg N/(ha yr), 7–49 kg N/(ha yr), and 105–150 kg N/ha, respectively. When comparing the spatial distribution of the soil nitrogen content, nitrogen fertilizer, and nitrogen deposition, we found that the soil nitrogen supply capacity emerged as the predominant factor controlling wheat grain production. Soil types, precipitation, and temperature demonstrated a notable positive correlation with the soil nitrogen supply capacity. Given this background, it would be unreasonable to rely solely on the soil nitrogen content as the standard for fertilizer management. Particularly in high-yield fields, our focus should be on preserving optimal soil fertility by placing greater emphasis on the soil nitrogen supply capacity rather than simply reducing fertilizer application during wheat growth.
Function of Soybean miR159 Family Members in Plant Responses to Low Phosphorus, High Salinity, and Abscisic Acid Treatment
Authors: Li Bodi , Tao Ping , Xu Feng , He Pingan , Wang Jinxiang
Published: July 2023

MicroRNAs (miRNAs) regulate plant growth and development and plant responses to biotic and abiotic stresses. Although extensive studies show that miR159 family members regulate leaf and flower development in Arabidopsis thaliana, the roles of miRNAs in soybean (Glycine max) are poorly understood. Here, we identified six MIR159 genes in soybean, MIR159a–MIR159f, and investigate their expression patterns in plants under low-phosphorus (low-P), NaCl, or abscisic acid (ABA) treatments. In soybean leaves, MIR159e and MIR159f expression was induced by low-P treatment, while in roots, MIR159b, MIR159c, MIR159e, and MIR159f expression was upregulated. In flowers, low-P led to upregulation of MIR159a, MIR159b, MIR159c, and MIR159f but downregulation of MIR159d and MIR159e. In soybean nodules, MIR159b was upregulated but MIR159a, MIR159c, and MIR159d was downregulated under P deficiency. NaCl treatment induced MIR159a, MIR159b, MIR159c, and MIR159e expression in leaves and MIR159a–MIR159f expression in roots. ABA treatment upregulated MIR159a, MIR159b, and MIR159c but downregulated MIR159d, MIR159e, and MIR159f in leaves. These results suggest that miR159 family members function in plant abiotic stress responses. Moreover, total P content in leaves was significantly lower in plants overexpressing MIR159e than in the wild type, suggesting that miR159e may regulate P absorption and transport in soybean plants.
Central and Peripheral Fatigue Evaluation during Physical Exercise in Athletic Horses by Means of Raman Spectroscopy
Authors: Acri Giuseppe , Testagrossa Barbara , Piccione Giuseppe , Arfuso Francesca , Giudice Elisabetta , Giannetto Claudia
Published: July 2023

The evaluation of the performance levels in athletic horses is of major importance to prevent sports injuries. Raman spectroscopy is an innovative technique that allows for a rapid evaluation of biomolecules in biological fluids. It also permits qualitative and quantitative sample analyses, which lead to the simultaneous determination of the components of the examined biological fluids. On the basis of this, the Raman spectroscopy technique was applied on serum samples collected from five Italian Saddle horses subjected to a standardized obstacle course preceded by a warm-up to evaluate the applicability of this technique for the assessment of central and peripheral fatigue in athletic horses. Blood samples were collected via jugular venipuncture in a vacutainer tube with a clot activator before exercise, immediately after exercise, and 30 min and 1 h after the end of the obstacle course. Observing the obtained Raman spectra, the major changes due to the experimental conditions appeared in the (1300–1360) cm−1 and (1385–1520) cm−1 bands. In the (1300–1360) cm−1 band, lipids and tryptophan were identified; in the (1385–1520) cm−1 band, leucine, glycine, isoleucine, lactic acid, tripeptide, adenosine, and beta carotene were identified. A significant effect of exercise was recorded on all the sub-bands. In particular, a change immediately after exercise versus before exercise was found. Moreover, the mean lactic concentration was positively correlated with the Raman area of the sub-band assigned to lactic acid. In this context, the application of Raman spectroscopy on blood serum samples represents a useful technique for secondary-structure protein identification to investigate the metabolic changes that occur in athletic horses during physical exercise.
Bacteria in Normal Canine Milk Analyzed by Blood Agar Medium
Authors: Kolasinac Sabina Sibcic , Moe Lars , Rootwelt Vibeke , Sørum Henning
Published: July 2023

Studies of microbiota in normal canine milk from healthy dams are sparse. As is the case with blood and urine, it was considered that milk contains no microbiota. Any discovery of bacteria in canine milk is, therefore, often noted to be a result of contamination during sampling or interpreted as mastitis and treated with antibiotics. Milk was collected twice within 19 days after natural parturition from 11 lactating dams, with no general or local clinical signs of mastitis or other disease. The skin and teats were prepared with an antimicrobial protocol prior to each milk sampling. In total, 210 milk samples were collected and assessed for a number of bacterial colonies grown on each plate. Bacterial growth was detected in 180 samples (86%). Staphylococcus pseudintermedius, Enterococcus spp., Clostridium spp., Coagulase-Negative Staphylococci (CoNS), Streptococcus spp., Streptococcus canis, Bacillus spp., Pasteurella spp., and Escherichia coli were identified from pure and/or mixed bacterial growth, listed in descending order of occurrence. Despite the small sample size, the consistent occurrence of bacteria in early postpartum dams indicates a genuine occurrence of bacteria in canine milk, rather than random contamination. The finding of bacteria in the milk of dams should not, therefore, be the sole argument for the diagnosis of mastitis.
RNA-Seq Analysis of Peripheral Whole Blood from Dairy Bulls with High and Low Antibody-Mediated Immune Responses—A Preliminary Study
Authors: Zhao Xiuxin , Luo Hanpeng , Lu Haibo , Ma Longgang , Li Yanqin , Dou Jinhuan , Zhang Junxing , Ma Yun , Li Jianbin , Wang Yachun
Published: July 2023

Enhancing the immune response through breeding is regarded as an effective strategy for improving animal health, as dairy cattle identified as high immune responders are reported to have a decreased prevalence of economically significant diseases. The identification of differentially expressed genes (DEGs) associated with immune responses might be an effective tool for breeding healthy dairy cattle. In this study, antibody-mediated immune responses (AMIRs) were induced by the immunization of hen egg white lysozyme (HEWL) in six Chinese Holstein dairy bulls divided into high- and low-AMIR groups based on their HEWL antibody level. Then, RNA-seq was applied to explore the transcriptome of peripheral whole blood between the two comparison groups. As a result, several major upregulated and downregulated genes were identified and attributed to the regulation of locomotion, tissue development, immune response, and detoxification. In addition, the result of the KEGG pathway analysis revealed that most DEGs were enriched in pathways related to disease, inflammation, and immune response, including antigen processing and presentation, Staphylococcus aureus infection, intestinal immune network for IgA production, cytokine–cytokine receptor interaction, and complement and coagulation cascades. Moreover, six genes (BOLA-DQA5, C5, CXCL2, HBA, LTF, and COL1A1) were validated using RT-qPCR, which may provide information for genomic selection in breeding programs. These results broaden the knowledge of the immune response mechanism in dairy bulls, which has strong implications for breeding cattle with an enhanced AMIR.
Characterization of FCI (Fédération Cynologique Internationale) Grades for Hip Dysplasia in Five Dog Breeds
Authors: Pinna Stefania , Vezzoni Aldo , Di Benedetto Matteo , Lambertini Carlotta , Tassani Chiara
Published: July 2023

The aim of this retrospective study was to verify whether the radiographic morphologic differences detected within the first three grades of hip dysplasia (A, B, C) of each of the five selected breeds and within the same breeds were statistically significant enough to require a breed-specific evaluation. A total of 422 technical evaluation forms of hip dysplasia (HD) in Labrador Retrievers, Golden Retrievers, Rottweilers, Bernese Mountain dogs, and German Shepherd dogs were obtained from the Fédération Cynologique Internationale (FCI) archive. The data were evaluated using a descriptive statistical analysis. In Labrador Retrievers, the craniolateral acetabular rim and femoral head position were already altered in unaffected dogs; however, within the various FCI grades, the most severe changes involved the conformation of the femoral neck. All the radiographic parameters of the Golden Retriever hips changed progressively and evenly. Significant radiographic changes between FCI grades were found in the German Shepherd dogs, and the alterations involving the acetabulum were more severe and appeared earlier than in the femoral head and neck. In the Bernese Mountain dogs, the most severe alterations were in the position of the femoral head and joint space while the femoral head and neck showed no significant progression between grades. All the radiographic parameters of non-dysplastic Rottweilers were normal; however, the progression of the primary signs was similar to the other breeds, although with lower severity. In conclusion, no significant prevalence of the radiographic features was observed for any specific breed. However, significant individual breed variations in the primary radiographic parameters were found between dogs with and without dysplasia which could be useful for better understanding the consequences of biomechanical differences between breeds.
An Ultrasound-Guided Latero-Ventral Approach to Perform the Quadratus Lumborum Block in Dog Cadavers
Authors: Marchina-Gonçalves André , Laredo Francisco G. , Gil Francisco , Soler Marta , Agut Amalia , Redondo José Ignacio , Belda Eliseo
Published: July 2023

The QL block is a high-level locoregional anesthesia technique, which aims to provide analgesia to the abdomen. Several approaches of the QL block have been studied to find out which one allows a greater distribution of the injectate. The aim of this study is to compare the traditional interfascial QL block (IQL) with a new latero-ventral approach (LVQL). We hypothesize that this new approach could be safer and easier to perform, since the injectate is administered more superficially and further away from vital structures. Our second objective is to assess whether a higher volume of injectate (0.6 mL/kg) could reach the ventral branches of the last thoracic nerves, leading to a blockade of the cranial abdomen. Six thawed canine cadavers (12 hemiabdomens) were used for this purpose. Both approaches were performed in all cadavers. A combination of methylene blue/iopromide was administered to each hemiabdomen, randomly assigned to the LVQL or IQL. No differences were found regarding the ease of perform the LVQL with respect to IQL. The results show that both techniques reached the ventral branches from L1 to L3, although only the IQL consistently stained the sympathetic trunk (5/6 IQL vs. 1/6 LVQL). The use of a higher volume did not enhance a more cranial distribution of the injectate.
Impact of Menopausal Status and Recurrent UTIs on Symptoms, Severity, and Daily Life: Findings from an Online Survey of Women Reporting a Recent UTI
Authors: Sanyaolu Leigh N. , Cooper Emily , Read Brieze , Ahmed Haroon , Lecky Donna M.
Published: July 2023

Introduction: Current UKHSA UTI diagnostic guidance advises empirical antibiotics if two of the following symptoms are present: cloudy urine, dysuria, and new onset nocturia. Hormonal changes during menopause may impact UTI symptoms, and qualitative studies suggest women with recurrent UTIs may present with different UTI symptoms. This study aims to assess whether menopausal status and the presence of recurrent UTIs impact UTI symptoms in women. Methods: An e-survey was conducted between 13 March 2021 and 13 April 2021. Women aged 16 years or older with a history of a UTI in the last year were eligible for inclusion. We defined menopause as those aged 45–64 years; pre-menopause as those less than 45 years; and post-menopause as those 65 years and older. Recurrent UTIs were defined as three or more UTIs in the last year. The data were weighted to be representative of the UK population. Crude unadjusted and adjusted odds ratios were estimated using logistic regression. Results: In total, 1096 women reported a UTI in the last year. There were significant differences in UTI symptoms based on menopausal status and the presence of recurrent UTIs. Post-menopausal women self-reported more incontinence (OR 2.76, 95% CI 1.50,5.09), whereas menopausal women reported more nocturia. Women with recurrent UTIs reported less dysuria, more severe symptoms (OR 1.93 95% CI 1.37,2.73) and a greater impact on daily life (OR 1.68, 95% CI 1.19,2.37). Conclusions: This survey provides evidence that acute UTIs present differently based on menopausal status and in women with recurrent UTIs. It is important that healthcare professionals are aware of these differences when assessing women presenting with an acute UTI and, therefore, further research in this area is needed.
Oral Tetracycline-Class Drugs in Dermatology: Impact of Food Intake on Absorption and Efficacy
Authors: Tao Rachel E. , Prajapati Stuti , Pixley Jessica N. , Grada Ayman , Feldman Steven R.
Published: July 2023

Tetracycline-class drugs are frequently used in dermatology for their anti-inflammatory properties to treat skin diseases such as acne, rosacea, and hidradenitis suppurativa (HS). The American Academy of Dermatology (AAD) clinical guidelines do not offer guidance regarding the co-administration of food with tetracycline-class drugs. The objectives of this study were to review the available evidence regarding whether taking tetracycline-class drugs with food decreases systemic absorption and is associated with an impact on clinical efficacy. A literature search was conducted using the PubMed database between February to May 2023 using the keywords “tetracycline-class drugs”, “pharmacokinetics”, “absorption”, and “dermatology”. Inclusion criteria included articles written in English and relevant to the absorption and efficacy of tetracycline-class drugs. This search yielded 131 articles written between 1977 to 2022, of which 29 met the criteria for review. United States Food and Drug Administration (FDA)-approved prescribing information for oral formulations of tetracycline, doxycycline, minocycline, and sarecycline were reviewed. Systemic absorption of tetracycline decreased when co-administered with food. Systemic absorption of oral doxycycline and minocycline was variable with food co-administration. The impact on bioavailability varied with the drug formulation and dosage. The absorption of oral sarecycline decreased when administered with food. Sarecycline is the only oral antibiotic where population pharmacokinetic studies demonstrated limited or no impact of food intake on clinical efficacy. There are no available data for other tetracycline-class drugs in dermatology. If patients find it more tolerable to take doxycycline, minocycline, and sarecycline with food to avoid gastrointestinal distress, this may merit consideration to encourage patient adherence. Since the impact of food intake on absorption varied with the dosage form of doxycycline and minocycline, consulting the appropriate package insert may give clinicians additional insight into differences in the various formulations.
Response of the Glutathione (GSH) Antioxidant Defense System to Oxidative Injury in Necrotizing Enterocolitis
Authors: Golubkova Alena , Leiva Tyler , Snyder Katherine , Schlegel Camille , Bonvicino Sarah M. , Agbaga Martin-Paul , Brush Richard S. , Hansen Jason M. , Vitiello Peter F. , Hunter Catherine J.
Published: July 2023

Necrotizing enterocolitis (NEC) is a neonatal intestinal disease associated with oxidative stress. The targets of peroxidation and the role of the innate intestinal epithelial antioxidant defense system are ill-defined. We hypothesized that oxidative stress in NEC correlates with oxidized GSH redox potentials, lipid peroxidation, and a dysfunctional antioxidant system. Methods: Intestinal samples from infants +/− NEC were generated into enteroids and incubated with lipopolysaccharide (LPS) and hypoxia to induce experimental NEC. HPLC assayed GSH redox potentials. Lipid peroxidation was measured by flow cytometry. Immunoblotting measured glutathione peroxidase 4 (Gpx4) expression. Results: GSH redox potentials were more oxidized in NEC intestinal tissue and enteroids as compared to controls. Lipid radicals in NEC-induced enteroids were significantly increased. Human intestinal tissue with active NEC and treated enteroid cultures revealed decreased levels of Gpx4. Conclusions: The ability of neonatal intestine to mitigate radical accumulation plays a role in its capacity to overcome oxidative stress. Accumulation of lipid radicals is confirmed after treatment of enteroids with NEC-triggering stimuli. Decreased Gpx4 diminishes a cell’s ability to effectively neutralize lipid radicals. When lipid peroxidation overwhelms antioxidant machinery, cellular death ensues. Identification of the mechanisms behind GSH-dependent enzyme dysfunction in NEC may provide insights into strategies for reversing radical damage.
Polycyclic Aromatic Hydrocarbon Occurrence and Formation in Processed Meat, Edible Oils, and Cereal-Derived Products: A Review
Authors: Palade Laurentiu Mihai , Negoiță Mioara , Adascălului Alina Cristina , Mihai Adriana Laura
Published: July 2023

The chemical group comprising polycyclic aromatic hydrocarbons (PAHs) has received prolonged evaluation and scrutiny in the past several decades. PAHs are ubiquitous carcinogenic pollutants and pose a significant threat to human health through their environmental prevalence and distribution. Regardless of their origin, natural or anthropogenic, PAHs generally stem from the incomplete combustion of organic materials. Dietary intake, one of the main routes of human exposure to PAHs, is modulated by pre-existing food contamination (air, water, soil) and their formation and accumulation during food processing. To this end, processing techniques and cooking options entailing thermal treatment carry additional weight in determining the PAH levels in the final product. With the background provided, this study aims to provide an improved understanding of PAH occurrence in meat, edible oils, and cereal products. The factors influencing PAH formation, including operational conditions and parameters, product composition, and storage settings, are described. The discussion also addresses reduction directions with respect to influencing factors informing the choice of the employed technique, fuel type, time–temperature settings, and ingredient variations. Considering the disparities caused by wide variations in PAH contamination, challenges associated with PAH control requirements are also outlined in the context of relevant preventive approaches during food processing.
Construction of Color Prediction Model for Damaged Korla Pears during Storage Period
Authors: Zhang Rui , Li Shiyuan , Liu Yang , Li Guowei , Jiang Xin , Fan Xiuwen
Published: July 2023

In this work, to scientifically predict the color of damaged Korla fragrant pears during the storage period with lower economic loss and improved added value of the fragrant pears, eight pericarp color prediction models of damaged Korla fragrant pears during the storage period were established. These models had different membership functions, which were based on the adaptive neuro-fuzzy inference system (ANFIS). The optimal model was chosen and verified. Finally, the pericarp color of fragrant pears was accurately predicted through the degree of damage and storage time. According to the acquired test results, the pericarp brightness (L*) decreased, while both the red–green (a*) and yellow–blue (b*) values increased as the storage time prolonged. In addition, the pericarp color of the damaged fragrant pears during the storage period could be well predicted by using the ANFIS model. More specifically, the model with a membership function of trimf showed the optimal prediction effects of L*, a*, and b* (RMSE = 0.1089, R2 = 0.9773; RMSE = 0.5894, R2 = 0.9853; and RMSE = 0.2360, R2 = 0.9772). Our work provides valuable insights for the prediction of the quality of Korla fragrant pears during the storage period.
A Study on Heater Design for Crystal Growth of GaAs Ingot Using Growth Temperature Simulation
Authors: Park Youngtae , Park Hyunbum
Published: July 2023

In this work, a study on large-diameter GaAs ingot growth is presented. Optimized temperature control technology is developed. Horizontal and vertical temperature application technologies with optimum conditions are investigated. The design result is verified through thermal analysis. In addition, polishing process technology for large-diameter GaAs substrates is developed. Simulation data were used to carry out experiments to determine the optimum temperature conditions. As a result of the defect analysis, the final manufacturing result is found to have excellent thickness variations. This presents the validity of the manufacturing process developed in this work.
Comparative Analysis of Hybrid-Electric Regional Aircraft with Tube-and-Wing and Box-Wing Airframes: A Performance Study
Authors: Palaia Giuseppe , Abu Salem Karim , Quarta Alessandro A.
Published: July 2023

The continuously expanding transport aviation sector has a significant impact on climate change, and measures must be taken to limit its environmental impact. The study of advanced airframes, which may increase the lift-to-drag ratio and structural efficiency, and the development of innovative high-efficient powertrains, could be a way to achieve air transport decarbonization. This paper explores this broad topic by proposing a classical performance comparison between an aircraft with a traditional tube-and-wing (TW) airframe and a corresponding one with an advanced box-wing (BW) lifting architecture, both equipped with a parallel hybrid-electric powertrain. In fact, the propulsion technologies selected for this comparative study are consistent with the 2035 forecast, and both aircraft concepts are designed to belong to the regional transport category. The comparison between TW and BW is conducted on a conceptual and multi-disciplinary level, offering an analysis of the competitive benefits and limitations in terms of the aerodynamic, structural, and propulsive performance of the two configurations. The metrics selected to make the comparison are related to aircraft performance, such as the structural weight, the block fuel, or the energy required to accomplish the assigned mission. The outcomes obtained highlight the potential of BW airframes coupled with hybrid-electric powertrains to reduce fuel consumption, and hence the related greenhouse gas emissions, because of improvements introduced by this advanced architecture in both the aircraft’s empty weight and energy efficiency.
Cognitive Load Approach to Digital Comics Creation: A Student-Centered Learning Case
Authors: Apostolou Dimitris , Linardatos Gerasimos
Published: July 2023

The use of comics and their creation is an especially promising tool to enable students to construct new knowledge. Comics have already been adopted in many applied sciences disciplines, as the combination of text and images has been recognized as a powerful learning tool. Educational activities and tools, however, must not create an overload on students’ working memory that could hinder learning. In the current study, we investigated, through pre-test and post-test performance, the effect of digital comics creation on students’ efforts to construct new knowledge. Furthermore, through the multidimensional NASA-TLX, we assessed the cognitive load imposed on students. The results were in favor of digital comics creation, ranking it as an efficient instructional activity. Specifically, the students’ performance after digital comics creation improved and the imposed load on students was normal. Also, studying the weighing procedure between the NASA-TLX dimensions, frustration and temporal demand were found to be the most aggravating dimensions. Finally, implications for teachers and future research recommendations are discussed.
Estimation of the Network Reliability for a Stochastic Cold Chain Network with Multi-State Travel Time
Authors: Nguyen Thi-Phuong , Huang Chin-Lung , Lin Yi-Kuei
Published: July 2023

A stochastic cold chain (SCC) is a common supply chain in real life that emphasizes the need for commodities to arrive fresh within time constraints. In previous research on supply chains, the time factor was regarded as a fixed number. However, the travel time is a stochastic factor due to traffic and weather conditions during the delivery. Therefore, this paper concentrates on the two multi-state factors simultaneously. Network reliability is one of the performance indexes used to assess the cold chain efficacy, defined as the probability that the flow of SCC can satisfy the demand within the delivery time threshold. The SCC with two multi-state factors is modeled as a stochastic cold chain network with multi-state travel time (SCCNMT). To calculate the network reliability of an SCCNMT, we will calculate the demand reliability and time reliability separately, treating them as independent events, and multiply the demand and time reliability to estimate the network reliability of the two multi-state factors.
Obtaining the Effective Dielectric Permittivity of a Conducting Surface in the Terahertz Range via the Characteristics of Surface Plasmon Polaritons
Authors: Gerasimov Vasily Valerievich , Nikitin Alexey Konstantinovich , Lemzyakov Alexey Georgievich , Azarov Ivan Aleksandrovich , Kotelnikov Igor Aleksandrovich
Published: July 2023

With the intensive development of data transmitting and processing devices in the terahertz (THz) frequency range, an important part of which are integrated plasmonic components and communication lines, it becomes necessary to measure correctly the optical constants of their conductive surfaces. In this paper, we describe a reliable method for determining the effective permittivity εm of a metal surface from the measured characteristics (refractive and absorption indices) of THz surface plasmon polaritons (SPPs). The novelty of the method is the conduction of measurements on a metal surface with a dielectric layer of subwavelength thickness, suppressing the radiative losses of SPPs, which are not taken into account by the SPP dispersion equation. The method is tested on a number of flat “gold sputtering–zinc sulfide layer–air” structures with the use of the THz radiation (λ0 = 141 μm) from the Novosibirsk free electron laser (NovoFEL). The SPP characteristics are determined from interferograms measured with a plasmon Michelson interferometer. It is found that the method allows a significant increase in the accuracy of the εm in comparison with measurements on the same metal surface without a dielectric layer.
One-Class Learning for AI-Generated Essay Detection
Authors: Corizzo Roberto , Leal-Arenas Sebastian
Published: July 2023

Detection of AI-generated content is a crucially important task considering the increasing attention towards AI tools, such as ChatGPT, and the raised concerns with regard to academic integrity. Existing text classification approaches, including neural-network-based and feature-based methods, are mostly tailored for English data, and they are typically limited to a supervised learning setting. Although one-class learning methods are more suitable for classification tasks, their effectiveness in essay detection is still unknown. In this paper, this gap is explored by adopting linguistic features and one-class learning models for AI-generated essay detection. Detection performance of different models is assessed in different settings, where positively labeled data, i.e., AI-generated essays, are unavailable for model training. Results with two datasets containing essays in L2 English and L2 Spanish show that it is feasible to accurately detect AI-generated essays. The analysis reveals which models and which sets of linguistic features are more powerful than others in the detection task.
Understanding the Effect of Age on Force Production and Symmetry during Water Exercises: Differences between Young Adults and Older Women
Authors: Santos Catarina C. , Soares Susana , Costa Mário J.
Published: July 2023

Participants from across the age span participate in water fitness sessions. This challenges instructors to create proper exercise prescriptions. The aim of this study was to understand the effect of age on force production and symmetry during water exercises. Twenty-six women were categorized into two groups: (i) young adult (n = 13; 23.61 ± 1.15 years) and (ii) older (n = 13; 67.38 ± 3.48 years). Women performed a horizontal upper limbs adduction during an incremental protocol comprising four music cadences increased every 30 s (105, 120, 135, and 150 b∙min−1). A differential pressure system composed of two sensors was used to measure the in-water force and to estimate the symmetry index. Young adults showed higher in-water forces (43–67 N) when compared with their older counterparts (31–55 N). No differences were observed between groups for the symmetry index. The cadences of 105–120 and 120–135 lead to different in-water force of the dominant limb in both groups, while the force of the non-dominant limb showed mix-findings. In conclusion, water fitness instructors should be aware that the same music cadence may trigger different kinetic behaviors in different ages, but without impairing symmetry when exercising at 120–135 b∙min−1.