bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Data 1 from GTP Signaling Links Metabolism, DNA Repair, and Responses to Genotoxic Stress
Authors: Zhou Weihua , Zhao Zitong , Lin Angelica , Yang John Z. , Xu Jie , Wilder-Romans Kari , Yang Annabel , Li Jing , Solanki Sumeet , Speth Jennifer M. , Walker Natalie , Scott Andrew J. , Wang Lu , Wen Bo , Andren Anthony , Zhang Li , Kothari Ayesha U. , Yao Yangyang , Peterson Erik R. , Korimerla Navyateja , Werner Christian K. , Ullrich Alexander , Liang Jessica , Jacobson Janna , Palavalasa Sravya , O’Brien Alexandra M. , Elaimy Ameer L. , Ferris Sean P. , Zhao Shuang G. , Sarkaria Jann N. , Győrffy Balázs , Zhang Shuqun , Al-Holou Wajd N. , Umemura Yoshie , Morgan Meredith A. , Lawrence Theodore S. , Lyssiotis Costas A. , Peters-Golden Marc , Shah Yatrik M. , Wahl Daniel R.
Published: January 2024

Supplementary Data 1 shows the original data of phosphoproteomic assay in Figure 2.
Supplementary Table 2 from SUV39H1 Ablation Enhances Long-term CAR T Function in Solid Tumors
Authors: López-Cobo Sheila , Fuentealba Jaime R. , Gueguen Paul , Bonté Pierre-Emmanuel , Tsalkitzi Kyriaki , Chacón Irena , Glauzy Salomé , Bohineust Armelle , Biquand Ariane , Silva Lisseth , Gouveia Zelia , Goudot Christel , Perez Franck , Saitakis Michael , Amigorena Sebastian
Published: January 2024

Numbers of cells analyzed by single-cell RNA-seq and identification genes used for cluster definitions. Related to Figures 3 and S4.
Supplementary Figures S1-S8 from SUV39H1 Ablation Enhances Long-term CAR T Function in Solid Tumors
Authors: López-Cobo Sheila , Fuentealba Jaime R. , Gueguen Paul , Bonté Pierre-Emmanuel , Tsalkitzi Kyriaki , Chacón Irena , Glauzy Salomé , Bohineust Armelle , Biquand Ariane , Silva Lisseth , Gouveia Zelia , Goudot Christel , Perez Franck , Saitakis Michael , Amigorena Sebastian
Published: January 2024

Supplementary Figures and Legends, Supplementary Table Legends
Supplementary Figure S1.Engineering SUV39H1-deficient human T cells. Supplementary Figure S2. SUV39H1-deficient T cells show enhanced stem/memory and less effector/exhausted phenotype. Supplementary Figure S3. SUV39H1 deletion in CAR T cells promotes stronger rejection of liquid and solid tumors. Supplementary Figure S4. Single-cell transcriptomics reveals enrichment of stem/memory cells and signatures in SUV39H1-deficient CAR T cells. Supplementary Figure S5. Enhanced self-renewal in SUV39H1-deficient stem/memory populations. Supplementary Figure 6. SUV39H1-deficient memory CAR T cell signature correlates with clinical response. Supplementary Figure 7. SUV39H1 ablation induces chromatin opening at stem/memory loci in all CAR T cell subpopulations. Supplementary Figure 8. SUV39H1-deficient BBz-CAR T cells show stronger memory persistence and mediate long-term protection against tumor rechallenge.
Table S5 from Quantifying the Expanding Landscape of Clinical Actionability for Patients with Cancer
Authors: Suehnholz Sarah P. , Nissan Moriah H. , Zhang Hongxin , Kundra Ritika , Nandakumar Subhiksha , Lu Calvin , Carrero Stephanie , Dhaneshwar Amanda , Fernandez Nicole , Xu Benjamin W. , Arcila Maria E. , Zehir Ahmet , Syed Aijazuddin , Brannon A. Rose , Rudolph Julia E. , Paraiso Eder , Sabbatini Paul J. , Levine Ross L. , Dogan Ahmet , Gao Jianjiong , Ladanyi Marc , Drilon Alexander , Berger Michael F. , Solit David B. , Schultz Nikolaus , Chakravarty Debyani
Published: January 2024

Table S5: Genes associated with an OncoKB Therapeutic Level of Evidence (1, 2 or 3A) in March of 2017
Supplementary Table S5 from AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity against Prostate Cancer
Authors: Nolan-Stevaux Olivier , Li Cong , Liang Lingming , Zhan Jinghui , Estrada Juan , Osgood Tao , Li Fei , Zhang Hanzhi , Case Ryan , Murawsky Christopher M. , Estes Bram , Moore Gregory L. , Bernett Matthew J. , Muchhal Umesh , Desjarlais John R. , Staley Binnaz K. , Stevens Jennitte , Cooke Keegan S. , Aeffner Famke , Thomas Oliver , Stieglmaier Julia , Lee Jae-Lyun , Coxon Angela , Bailis Julie M.
Published: January 2024

Cell lines used in this study.
Figure S2 from Quantifying the Expanding Landscape of Clinical Actionability for Patients with Cancer
Authors: Suehnholz Sarah P. , Nissan Moriah H. , Zhang Hongxin , Kundra Ritika , Nandakumar Subhiksha , Lu Calvin , Carrero Stephanie , Dhaneshwar Amanda , Fernandez Nicole , Xu Benjamin W. , Arcila Maria E. , Zehir Ahmet , Syed Aijazuddin , Brannon A. Rose , Rudolph Julia E. , Paraiso Eder , Sabbatini Paul J. , Levine Ross L. , Dogan Ahmet , Gao Jianjiong , Ladanyi Marc , Drilon Alexander , Berger Michael F. , Solit David B. , Schultz Nikolaus , Chakravarty Debyani
Published: January 2024

For solid tumor samples from the MSK-IMPACT subset of the AACR Project GENIE dataset with n≥100, (a) the median number of oncogenic and actionable (gray), oncogenic and non-actionable (light blue), or total (orange) mutations per sample per cancer type, and (b) the percentage of samples that carry zero, one, two, or three or more actionable mutations (as defined by OncoKB version October 2022) per sample.
Supplementary Figure S3 from AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity against Prostate Cancer
Authors: Nolan-Stevaux Olivier , Li Cong , Liang Lingming , Zhan Jinghui , Estrada Juan , Osgood Tao , Li Fei , Zhang Hanzhi , Case Ryan , Murawsky Christopher M. , Estes Bram , Moore Gregory L. , Bernett Matthew J. , Muchhal Umesh , Desjarlais John R. , Staley Binnaz K. , Stevens Jennitte , Cooke Keegan S. , Aeffner Famke , Thomas Oliver , Stieglmaier Julia , Lee Jae-Lyun , Coxon Angela , Bailis Julie M.
Published: January 2024

Structure determination of the AMG 509
Fab:STEAP1 complex
Supplementary Figure S2 from AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity against Prostate Cancer
Authors: Nolan-Stevaux Olivier , Li Cong , Liang Lingming , Zhan Jinghui , Estrada Juan , Osgood Tao , Li Fei , Zhang Hanzhi , Case Ryan , Murawsky Christopher M. , Estes Bram , Moore Gregory L. , Bernett Matthew J. , Muchhal Umesh , Desjarlais John R. , Staley Binnaz K. , Stevens Jennitte , Cooke Keegan S. , Aeffner Famke , Thomas Oliver , Stieglmaier Julia , Lee Jae-Lyun , Coxon Angela , Bailis Julie M.
Published: January 2024

Avidity-dependent activity of AMG 509.
Supplementary Figure S1 from AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity against Prostate Cancer
Authors: Nolan-Stevaux Olivier , Li Cong , Liang Lingming , Zhan Jinghui , Estrada Juan , Osgood Tao , Li Fei , Zhang Hanzhi , Case Ryan , Murawsky Christopher M. , Estes Bram , Moore Gregory L. , Bernett Matthew J. , Muchhal Umesh , Desjarlais John R. , Staley Binnaz K. , Stevens Jennitte , Cooke Keegan S. , Aeffner Famke , Thomas Oliver , Stieglmaier Julia , Lee Jae-Lyun , Coxon Angela , Bailis Julie M.
Published: January 2024

AMG 509 specificity for STEAP1.
Data from First-in-Human Study of the Reversible BTK Inhibitor Nemtabrutinib in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia and B-Cell Non–Hodgkin Lymphoma
Authors: Woyach Jennifer A. , Stephens Deborah M. , Flinn Ian W. , Bhat Seema A. , Savage Ronald E. , Chai Feng , Eathiraj Sudharshan , Reiff Sean D. , Muhowski Elizabeth M. , Granlund Lindsey , Szuszkiewicz Lyndsey , Wang Wayne , Schwartz Brian , Ghori Razi , Farooqui Mohammed Z.H. , Byrd John C.
Published: January 2024

Abstract
Nemtabrutinib is an orally bioavailable, reversible inhibitor of Bruton tyrosine kinase (BTK) and C481S mutant BTK. We evaluated the safety, pharmacology, and antitumor activity of nemtabrutinib in relapsed/refractory hematologic malignancies. Forty-eight patients with chronic lymphocytic leukemia (CLL), B-cell non–Hodgkin lymphoma (NHL), or Waldenström macroglobulinemia (WM), relapsed/refractory after ≥2 prior therapies were enrolled in the open-label, single-arm, phase I MK-1026-001 study (NCT03162536) to receive nemtabrutinib 5 to 75 mg once daily in 28-day cycles. Dose finding progressed using a 3 + 3 dose escalation design. Primary endpoints were safety and the recommended phase II dose (RP2D). Among 47 treated patients, 29 had CLL, 17 had NHL, and 1 had WM. Grade ≥3 treatment-emergent adverse events occurred in 37 (89%), most commonly neutropenia (11; 23.4%), febrile neutropenia (7; 14.9%), and pneumonia (7; 14.9%). The RP2D was 65 mg daily. An overall response rate of 75% was observed in patients with CLL at 65 mg daily.
Significance:
This first-in-human phase I study demonstrates the safety and preliminary efficacy of nemtabrutinib in patients with relapsed/refractory B-cell malignancies. These data support further exploration of nemtabrutinib in larger clinical studies.

This article is featured in Selected Articles from This Issue, p. 5
Bispecific T-cell Engagers in Metastatic Castration-Resistant Prostate Cancer
Authors: Hage Chehade Chadi , Gebrael Georges , Agarwal Neeraj
Published: January 2024

To date, immune targeting agents have provided limited benefits in patients with metastatic prostate cancer. Bispecific T-cell engagers, especially targeting STEAP1, have shown encouraging results in preclinical and phase I studies and thus represent a novel and promising treatment option in this setting.

See related article by Nolan-Stevaux et al., p. 90 (7).

See related article by Kelly et al., p. 76 (8).
Tumor-Derived RAB21+ABHD12+ sEVs Drive the Premetastatic Microenvironment in the Lung
Authors: Wu Kun , Li Yan , Ji Yikang , Liu Chun , Wang Xiaoning , Guo Haiyan , Zhang Jianjun , He Yue
Published: January 2024

Tumor metastasis is a spatial and temporal process that starts with remodeling to generate a proper premetastatic niche in a distant tissue. Infiltration of immunosuppressive macrophages is one of the notable characteristics in the premetastatic niche, which is a fundamental requirement for primary tumor metastasis. Here, we demonstrated that small extracellular vesicles (sEV) carrying RAB21 homed to lung macrophages and interacted with integrin-β1 on macrophages. ABHD12 expression was high in lung metastatic tumors and was mostly expressed by macrophages. Head and neck squamous cell carcinoma (HNSCC)–derived sEVs carrying ABHD12-polarized macrophages toward an immunosuppressive phenotype, driving premetastatic niche formation, which facilitated lung metastasis. ABHD12 additionally upregulated S1PR1 by activating the AKT–FoxO1 pathway in macrophages, and significantly enhanced antitumor responses were observed in tumor models treated with agents targeting both S1PR1 and PD-1. Collectively, our study suggests that RAB21+ABHD12+ sEVs derived from HNSCC cells contribute to the formation of the immunosuppressive microenvironment in the premetastatic niche and are a potential therapeutic target for enhancing the antitumor efficacy of anti–PD-1 therapy.
Supplementary Table S3 from A Systems Biology Approach to Understand the Racial Disparities in Colorectal Cancer
Authors: Nwaokorie Annabelle , Kolch Walter , Fey Dirk
Published: January 2024

This file contains the results to the survival analysis performed across each patient cohort for each signal transduction network.
Supplementary Table S2 from A Systems Biology Approach to Understand the Racial Disparities in Colorectal Cancer
Authors: Nwaokorie Annabelle , Kolch Walter , Fey Dirk
Published: January 2024

This file contains an overview of the datasets used and the analyses performed.
FIGURE 2 from A Systems Biology Approach to Understand the Racial Disparities in Colorectal Cancer
Authors: Nwaokorie Annabelle , Kolch Walter , Fey Dirk
Published: January 2024

Kaplan–Meier curves of overall survival for the most significant gene of each colorectal cancer STN for the Black/AA and White cohort. A, WNT7B for WNT STN for the Black/AA cohort. B, CSNK1A1 for WNT STN for the White cohort. C, TP73 for TP53 STN for the Black/AA cohort. D, IGFBP3 for TP53 STN for the White cohort. E, EID2 for TGFβ STN for the Black/AA cohort. F, RAC1 for TGFβ STN for the White cohort. G, NTF4 for PI3K-Akt STN for the Black/AA cohort. H, BRAC1 for PI3K-Akt STN for the White cohort. I, EIF4E for mTOR STN for the Black/AA cohort. J, RRAGB for mTOR STN for the White cohort. K, CACNA2D4 for MAPK STN for the Black/AA cohort. L, TGFB2 for MAPK and Cell Cycle STN for the White cohort. M, YWHAQ for Cell Cycle STN for the Black/AA cohort. N, CASP6 for Apoptosis STN for the Black/AA cohort. O, IKBKG for Apoptosis STN for the White cohort. P, NOTCH3 for Notch STN for the Black/AA cohort. Q, DTX1 for Notch STN for the White cohort. The patients were stratified into two groups according to the expression level of the indicated gene. The optimal cutoff was determined using Kaplan–Meier scanning (see Materials and Methods). The groups are represented as high (orange line), and low (blue line), where n indicates the total number of patients in each group. Statistical significance was tested using a log-rank test. HR = hazard ratio. CI95% = 95% confidence interval. P-val = P-value.
FIGURE 1 from A Systems Biology Approach to Understand the Racial Disparities in Colorectal Cancer
Authors: Nwaokorie Annabelle , Kolch Walter , Fey Dirk
Published: January 2024

Distribution of the log2 HRs from Black/AA and White cohorts. A, All genes analyzed in each STN combined. B, The subset of genes significant in both cohorts (overlapping significant genes). Blue, genes with concordant survival associations. Red, genes with opposing survival associations between the Black/AA and White cohorts: LAMB4 (HR Black/AA: 2.5976, White: 0.1145), SUMO1 (HR Black/AA: 1.8014, White: 0.2320), IFNAR1 (HR Black/AA: 2.8226, White: 0.2461), DLL3 (HR Black/AA: 1.6974, White: 0.2236), CCND3 (HR Black/AA: 1.6956, White: 0.3233), CHD8 (HR Black/AA: 0.5704, White: 5.1594), AKT1 (HR Black/AA: 0.3929, White: 3.8042), and FZD6 (HR Black/AA: 0.1856, White: 3.5509).
Mac-2-Binding Protein Glycosylation Isomer to Albumin Ratio Predicts Bacterial Infections in Cirrhotic Patients
Authors: Wu Pei-Shan , Hsieh Yun-Cheng , Lee Pei-Chang , Yang Tsung-Chieh , Chen Yu-Jen , Yang Ying-Ying , Huang Hui-Chun , Hsu Shao-Jung , Huo Teh-Ia , Lee Kuei-Chuan , Lin Han-Chieh , Hou Ming-Chih
Published: January 2024

Introduction: Mac-2-binding protein glycosylation isomer (M2BPGi) is a novel biomarker for liver fibrosis, but little is known about its role in cirrhosis-associated clinical outcomes. This study aimed to investigate the predictive role of M2BPGi in cirrhosis-associated complications. Methods: One hundred and forty-nine cirrhotic patients were retrospectively enrolled. Patients were followed up for 1 year, and cirrhosis-associated clinical events were recorded. Receiver operating characteristic curve (ROC) analysis was used to establish the values of the predictive models for cirrhotic outcomes, and Cox proportional hazards regression models were used to identify predictors of clinical outcomes. Results: Sixty (40.3%) patients experienced cirrhosis-associated clinical events and had higher M2BPGi levels compared to those without events (8.7 vs. 5.1 cutoff index, p < 0.001). The most common cirrhosis-associated complications were bacterial infections (24.2%). On ROC analysis, M2BPGi to albumin ratio (M2BPGi/albumin) had comparable discriminant abilities for all cirrhosis-associated events (area under the ROC curve [AUC] = 0.74) compared with M2BPGi, Child-Pugh, model for end-stage liver disease, albumin-bilirubin scores, and neutrophil-to-lymphocyte ratio and was superior to M2BPGi alone for all bacterial infectious events (AUC = 0.80). Cox regression analysis revealed that the M2BPGi/albumin, but not M2BPGi alone, independently predicted all cirrhosis-associated events (hazard ratio [HR] = 1.34, p = 0.038) and all bacterial infectious events (HR = 1.51, p = 0.011) within 1 year. However, M2BPGi/albumin did not predict other cirrhotic complications and transplant-free survival. Discussion/Conclusion: M2BPGi/albumin might serve as a potential prognostic indicator for patients with cirrhosis, particularly for predicting bacterial infections.
Spontaneous Reattachment of a Detached Sutured Descemet-Stripping Automated Endothelial Keratoplasty Graft
Authors: Gad Rania E. , Kahn Jonathan , Trief Danielle
Published: January 2024

Introduction: This is a case report of a spontaneous reattachment of Descemet-stripping automated endothelial keratoplasty (DSAEK). This graft was primarily sutured, and 20% sulfur hexafluoride (SF6) was injected into the anterior chamber, followed by graft detachment and spontaneous reattachment, 3 months later. Case Presentation: A 78-year-old male presented with DSAEK graft detachment, which was the patient’s second DSAEK (the first also did not adhere). During the second surgery, the DSAEK graft was sutured and 20% SF6 was injected intraoperatively. Graft reattachment occurred without any intervention or repositioning 3 months after the 2nd DSAEK surgery. Conclusion: Spontaneous DSEAK late graft reattachment is possible, particularly in the setting of an anchoring suture. In some patients, waiting can be an option that can spare the patient the possible risks of graft repositioning, rebubbling, or repeating the DSAEK. Suturing the DSAEK graft primarily may have served as an anchor to keep the graft approximate and aid in attachment. A graft suture can be considered in the setting of a previously failed DSAEK due to DSAEK graft detachment.
Achieving Cochlear Therapeutic Hypothermia through Irrigation of the Mastoid and Tympanic Cavities
Authors: Beatrous Britton , Arteaga Alberto A. , Mckee Elizabeth , Spankovich Christopher
Published: January 2024

Introduction: Mild therapeutic hypothermia (MTH) is an exciting nonpharmaceutical otoprotection strategy. In this study, we applied simple irrigation of the tympanic and mastoid cavities to understand the timing of both achieving MTH and recovery back to euthermic temperatures for application in the clinical setting. Methods: Three human temporal bones were used in this study in the temporal bone laboratory. A standard mastoidectomy was performed on each followed by the insertion of temperature probes into the basal turn of the cochlea via a middle cranial fossa approach. The temporal bones were warmed in heated bead baths to 37°C. The tympanic and mastoid cavities were then irrigated with room temperature water, and intracochlear temperature readings were recorded every minute. After 15 min, irrigation was stopped, and temperature readings were collected until temporal bones returned to euthermic levels. Results: Intracochlear MTH was achieved within the first minute of irrigating the tympanic and mastoid cavities. Intracochlear temperatures plateaued after 5 min around 30°C. Discontinuation of irrigation resulted in the temperature rising logarithmically above the MTH levels after 9–10 min. Conclusion: Intracochlear MTH can be achieved via irrigation of the tympanic and mastoid cavities with room temperature irrigation within 60 s. After irrigation for 5 min, hypothermic temperatures will remain therapeutic for 10 min following cessation of irrigation.
Application of gut bacterial profiling information in precision nutrition for obesity and weight loss management
Authors: Ramos-Lopez Omar , Aranaz Paula , Riezu-Boj Jose I. , Milagro Fermin I.
Published: January 2024

Background: It has been suggested that the dysfunction of the gut microbiome can have deleterious effects on the regulation of body weight and adiposity by affecting energy metabolism. In this context, gut bacterial profiling studies have contributed to characterize specific bacteria associated with obesity. This review covers the information driven by gut bacterial profiling analyses and emphasizes the potential application of this knowledge in precision nutrition strategies for obesity understanding and weight loss management.
Summary: Gut bacterial profiling studies have identified bacterial families that are more abundant in obese than in non-obese individuals (i.e. Prevotellaeae, Ruminococcaceae, and Veillonellaceae) as well as other families that have been repeatedly found more abundant in non-obese people (i.e. Christensenellaceae and Coriobacteriaceae), suggesting that an increase in their relative amount could be an interesting target in weight-loss treatments. Also, some gut-derived metabolites have been related to the regulation of body weight, including short chain fatty acids (SCFA), trimethylamine-N-oxide (TMAO), and branched-chain and aromatic amino acids. Moreover, gut microbiota profiles may play a role in determining weight loss responses to specific nutritional treatments for the precise management of obesity. Thus, incorporating gut microbiota features may improve the performance of integrative models to predict weight loss outcomes.
Key Messages: The application of gut bacterial profiling information is of great value for precision nutrition in metabolic diseases, since it contributes to the understanding of the role of the gut microbiota in obesity onset and progression, facilitates the identification of potential microorganism targets, and allows the personalization of tailored weight loss diets as well as the prediction of adiposity outcomes based on the gut bacterial profiling of each individual. Integrating microbiota information with other omics knowledge (genetics, epigenetics, transcriptomics, proteomics, and metabolomics) may provide a more comprehensive understanding of the molecular and physiological events underlying obesity and adiposity outcomes for precision nutrition.
Associations between Urinary Concentrations of Polycyclic Aromatic Hydrocarbons and Overactive Bladder in US Adults: Data from the National Health and Nutrition Examination Survey 2005–2016
Authors: Pu Shihang , Li Qi , Tao Zhijun , Wang Songbo , Meng Xiangyu , Wang Shangqian , Wang Zengjun
Published: January 2024

Introduction: Polycyclic aromatic hydrocarbons (PAHs) are a group of chemicals that can induce oxidative stress and related cytotoxicity. Whether urinary concentrations of PAHs have effects on overactive bladder (OAB) in the general population is still unclear. This study investigated the associations between urinary PAHs and OAB. Methods: 7,146 adults aged over 20 who participated in the US National Health and Nutrition Examination Survey 2005–2016 were studied. The impact of the six PAHs on OAB was evaluated by multivariate logistic regression, and percent changes related to different quartiles of those six PAH levels were calculated. Confounders including age, logarithmic urinary creatinine, gender, race, body mass index, educational level, marriage, poverty income ratio, diabetes, hypertension, and metabolic syndrome were controlled. Results: There is a significant positive correlation between urinary concentrations of the six PAHs we include in the study and the occurrence of OAB. Furthermore, individuals with higher PAH levels also reported a more severe OAB symptom score (OABSS). Conclusions: Our findings revealed that adult men in the USA with higher urinary PAHs had a higher risk of OAB incidence. These findings suggest the importance of strong environmental regulation of PAHs to protect population health. However, the underlying mechanisms still need further exploration.
On the object of a functional semiology: towards a typology of indices
Authors: Barreto Eugenio Israel Chávez
Published: January 2024

The article touches upon two problems that arose in the development of semiology in the second half of the twentieth century, namely: (1) the debate over the proper object of semiology: signification or communication? and (2) the problem of how a typology of indices (indications), which underlies the conception of the proper object of semiology, can be established. In order to tackle these problems, the article restricts itself to a treatment of the works by the main representatives of a functional semiology, to wit, Georges Mounin, Eric Buyssens and Luis Prieto. Especially the works of Prieto are used to unravel a typology of indices that ultimately allows to conceive the object of a specific semiology of signification and to clearly present its aims.
Quatre questions sur la sémiotique : son histoire, sa place, ses bases épistémologiques
Authors: Badir Sémir , Cigana Lorenzo , Lemos Carolina Lindenberg , Sofia Estanislao
Published: January 2024

À l’occasion de la publication de Pratiques discursives du savoir. Le cas sémiotique (2022), les animateurs du présent dossier ont adressé à son auteur, Sémir Badir, quatre questions relatives à l’historiographie et l’épistémologie de la sémiotique. La première question aborde différentes manières de concevoir l’histoire de la sémiotique, soit autour d’un projet théorique, soit autour d’une notion, en cherchant à identifier son destinataire idéal. La deuxième question porte sur les liens entre les théories de Saussure, de Hjelmslev et de Greimas. Badir défend l’intérêt d’une approche discursive (plutôt que notionnelle ou théorique), consistant à mettre en évidence le contexte disciplinaire, la matérialité du discours ainsi que le domaine épistémique dans lesquels ces liens sont posés, s’affichent et se rendent actifs. Un troisième volet concerne l’évolution de la sémiotique postgreimassienne. L’existence d’un programme de recherche n’est pas douteuse. Mais, au lieu de conduire à des applications étendues, la sémiotique revient constamment vers ses propres fondements théoriques. On s’interroge finalement sur les rapports qu’entretient la sémiotique avec les disciplines voisines. Le programme de la sémiotique prétend avoir des répercussions sur l’organisation générale des sciences, mettant ainsi en évidence le statut épistémologique particulier, non disciplinarisé, de cette pratique discursive du savoir.
Influência da demanda verde de clientes e do eco controle na ecoinovação e no crescimento sustentável das empresas do setor da carne bovina
Authors: Bortoluzzi Daiane Antonini , Lunkes Rogério João , Zambra Elisandra Marisa
Published: January 2024

A pesquisa tem por objetivo analisar a influência da demanda verde de clientes e do eco controle na ecoinovação e no crescimento sustentável em empresas do setor de carne bovina. Para atingir o objetivo foi aplicado um questionário com gestores de 95 empresas do setor da carne bovina do Brasil. Os dados foram analisados por meio da modelagem de equações estruturais (PLS-SEM). Os resultados mostram que o eco controle afeta positivamente e significativamente a ecoinovação e o crescimento sustentável. A demanda verde do cliente e ecoinovação influenciam no crescimento sustentável das empresas de carne bovina. Ainda mostramos que ecoinovação exerce um papel importante na relação entre eco controle e crescimento sustentável. Os resultados demonstram que não apenas os ecocontroles melhoram o crescimento sustentável, mas também que a ecoinovação pode trazer resultados complementares importantes na gestão ambiental.
Comunicação e liderança: em busca da dimensão sensível
Authors: Christofoli Márcia Pillon , Scroferneker Cleusa Maria Andrade
Published: January 2024

Neste artigo nos propomos a discutir sobre a dimensão sensível da liderança, ancorada na ideia de hermenêutica em profundidade (Thompson, 2009). A articulação entre o referencial teórico e as entrevistas realizadas com os líderes da Aliança para Inovação evidenciou que a liderança sensível está aberta ao diálogo, ao conhecimento compartilhado e à escuta. Viabiliza-se na dimensão do afeto e da espiritualidade, no sentido de reconhecimento do outro como seu igual, ou seja, na dimensão humana e sensível da comunicação.
Provider Care Segregation and Hospital‐Region Racial Disparities in the United States for Acute Ischemic Stroke and Endovascular Therapy Outcomes
Authors: Daniel David , Maillie Luke , Dhamoon Mandip S.
Published: January 2024

Background

Reasons for racial disparities in the use and outcomes of endovascular treatment (ET) are not known. We examined patterns in care segregation for acute ischemic stroke (AIS) in the United States, and outcomes of segregation of care after ET.

Methods and Results

We used deidentified Medicare data sets to identify AIS admissions between January 1, 2016 and December 31, 2019, using validated
International Classification of Diseases, Tenth Revision
(
ICD‐10
) codes. For AIS, we calculated (1) the proportion of White patients at the hospital, (2) the proportional difference in the proportion of White patients between hospital patients and the county, and (3) provider care segregation by the dissimilarity index for ET cases. Using unadjusted and adjusted multilevel logistic models, we examined associations between measures of segregation and outcomes of discharge home, inpatient mortality, and 30‐day mortality. The mean proportional difference in the proportion of White patients comparing hospitalized patients with AIS to the county race distribution was 0.015 (SD, 0.219) at the hospital level. For ET, the mean proportional difference in the proportion of White patients comparing patients receiving ET to the county race distribution was much higher, at 0.146 (SD, 0.374). The dissimilarity index for ET providers was high, with a mean of 0.48 (SD, 0.29) across all hospitals. Black patients with AIS (compared with White patients) had reduced odds of discharge home, inpatient mortality, and 30‐day mortality.

Conclusions

In this national study with contemporary data in the endovascular era of AIS treatment, we found substantial evidence for segregation of care in the United States, not for only AIS in general but also especially for ET.
Association of Periprocedural Inflammatory Activation With Increased Risk for Early Coronary Stent Thrombosis
Authors: Krychtiuk Konstantin A. , Bräu Konstantin , Schauer Stephanie , Sator Alexander , Galli Lukas , Baierl Andreas , Hengstenberg Christian , Gangl Clemens , Lang Irene M. , Roth Christian , Berger Rudolf , Speidl Walter S.
Published: January 2024

Background

Stent thrombosis is a rare but deleterious event. Routine coronary angiography with percutaneous coronary intervention (PCI) is often deferred in the presence of laboratory markers of acute inflammation to prevent complications. The aim of this study was to investigate whether an acute inflammatory state is associated with an increased risk of early stent thrombosis.

Methods and Results

Within a prospective single‐center registry, the association between preprocedural acute inflammatory activation, defined as C‐reactive protein plasma levels >50 mg/L or a leukocyte count >12 g/L, and occurrence of early (≤30 days) stent thrombosis was evaluated. In total, 11 327 patients underwent PCI and of those, 6880 patients had laboratory results available. 49.6% of the study population received PCI for an acute coronary syndrome and 50.4% for stable ischemic heart disease. In patients with signs of acute inflammatory activation (24.9%), PCI was associated with a significantly increased risk for stent thrombosis (hazard ratio, 2.89;
P
<0.00001), independent of age, sex, kidney function, number and type of stents, presence of multivessel disease, choice of P2Y12 inhibitor, and clinical presentation. Elevated laboratory markers of acute inflammation were associated with the occurrence of stent thrombosis in both patients with acute coronary syndrome (hazard ratio, 2.63;
P
<0.001) and in patients with stable ischemic heart disease (hazard ratio, 3.57;
P
<0.001).

Conclusions

An acute inflammatory state at the time of PCI was associated with a significantly increased risk of early stent thrombosis. Evidence of acute inflammation should result in deferred PCI in elective patients, while future studies are needed for patients with acute coronary syndrome.
Use of Technetium‐99m‐Pyrophosphate Single‐Photon Emission Computed Tomography/Computed Tomography in Monitoring Therapeutic Changes of Eplontersen in Patients With Hereditary Transthyretin Amyloid Cardiomyopathy
Authors: Yu An‐Li , Chen Yi‐Chieh , Tsai Cheng‐Hsuan , Wu Yuan‐Kun Aden , Su Mao‐Yuan , Chou Chia‐Hung , Shun Chia‐Tung , Hsueh Hsueh‐Wen , Juang Jimmy Jyh‐Ming , Lee Ming‐Jen , Tseng Ping‐Huei , Hsu Chia‐Hua , Hsieh Sung‐Tsang , Ko Chi‐Lun , Cheng Mei‐Fang , Chao Chi‐Chao , Lin Yen‐Hung
Published: January 2024

Background

Hereditary transthyretin amyloid cardiomyopathy (hATTR‐CM) is a progressive and fatal disease. Recent evidence indicates that bone scintigraphy may serve as a tool to monitor the effectiveness of hATTR‐CM treatment. The objective of this study was to examine how eplontersen therapy influences the semiquantitative uptake of technetium‐99m‐pyrophosphate in individuals diagnosed with hATTR‐CM.

Methods and Results

We retrospectively analyzed a prospective cohort from the NEURO‐TTRansform trial, including patients with hATTR‐CM receiving eplontersen (45 mg/4 weeks). A control group comprised patients with hATTR‐CM who had not received eplontersen, inotersen, tafamidis, or patisiran. Technetium‐99m‐pyrophosphate single‐photon emission computed tomography/computed tomography was conducted at baseline and during follow‐up. Thirteen patients with hATTR‐CM were enrolled, with 6 receiving eplontersen and 7 serving as the control group. The median follow‐up time was 544 days. The eplontersen group exhibited a significant decrease in volumetric heart and lung ratio (3.774 to 2.979,
P
=0.028), whereas the control group showed no significant change (4.079 to 3.915,
P
=0.237). Patients receiving eplontersen demonstrated a significantly greater reduction in volumetric heart and lung ratio compared with the control group (−20.7% versus −3.4%,
P
=0.007).

Conclusions

The volumetric heart and lung ratio used to quantify technetium‐99m‐pyrophosphate uptake showed a significant reduction subsequent to eplontersen treatment in individuals diagnosed with hATTR‐CM. These findings suggest the potential efficacy of eplontersen in treating hATTR‐CM and highlight the value of technetium‐99m‐pyrophosphate single‐photon emission computed tomography/computed tomography as a tool for monitoring therapeutic effectiveness.
Parent–Offspring Associations of Ideal Cardiovascular Health Metrics: Findings From the 2014 to 2021 Korea National Health and Nutrition Examination Survey
Authors: Hoang Manh Thang , Jung Sun Jae , Lee Hokyou , Kim Hyeon Chang
Published: January 2024

Background

Studies have reported the strength of cardiovascular health (CVH) metrics in parent–offspring relationships. This study aimed to describe the sex‐specific associations between CVH in parents and adult offspring.

Methods and Results

This study was conducted on the Korea National Health and Nutrition Examination Survey data set, which analyzed trios of mother–father–child, with the child's age from 20 to 39 years. To use the nature of sampling design, survey weighting was applied to all our analyses. Ideal CVH was defined as a cluster of at least 5 ideal individual CVH metrics. We examined the association between parents and their adult offspring regarding clustering CVH and individual CVH metrics through odds ratios and 95% CIs using multiple logistic regression with standard errors adjusted for within‐family clustering. The study included 1267 married couples comprising 748 sons and 819 daughters. After adjusting for household income and offspring's sex, age, education, and alcohol consumption, an offspring with either parent attaining a nonideal CVH was 3.52 times more likely to have nonideal CVH. Fathers' nonideal CVH was significantly positively associated with the daughters' nonideal CVH. Maternal nonideal CVH was significantly positively associated with the son's nonideal CVH. When analyzing individual CVH metrics, ideal status in fathers or mothers reduced the likelihood of their offspring having a nonideal status.

Conclusions

This cross‐sectional study showed positive and differential associations of CVH and its components between parents' and offsprings' nonideal status. Our hypothesis‐generating results suggest the relevance of using CVH as a composite indicator in family‐centered approaches and heart‐health interventions.
Association Between Clonal Hematopoiesis Driver Mutations, Immune Cell Function, and the Vasculometabolic Complications of Obesity
Authors: Tercan Helin , Cossins Benjamin C. , van Deuren Rosanne C. , Rutten Joost H. W. , Joosten Leo A. B. , Netea Mihai G. , Hoischen Alexander , Bekkering Siroon , Riksen Niels P.
Published: January 2024

Background

Obesity is accompanied by dysregulated inflammation, which can contribute to vasculometabolic complications including metabolic syndrome and atherosclerosis. Recently, clonal hematopoiesis of indeterminate potential (CHIP) has emerged as a risk factor for cardiovascular diseases. We aimed to determine how CHIP is related to immune cell function, systemic inflammation, and vasculometabolic complications in obese individuals.

Methods and Results

Two hundred ninety‐seven individuals with overweight and obesity, between the ages of 54 and 81 years, were recruited in a cross‐sectional study. Clonal hematopoiesis driver mutations (CHDMs) were identified with an ultrasensitive targeted assay. Assessment of carotid artery atherosclerosis was performed with ultrasound. Detailed immunological parameters, including cytokine production capacity of peripheral blood mononuclear cells, and targeted plasma proteomics analysis, were studied. Adipose tissue inflammation was determined in subcutaneous fat biopsies. Individuals with CHIP had higher concentrations of circulating IL (interleukin)‐6. Total number of leukocytes and neutrophils were higher in individuals with CHIP. In contrast, ex vivo cytokine production capacity of peripheral blood mononuclear cells was significantly lower in individuals with CHIP. Sex‐stratified analysis showed that men with CHDMs had significantly higher leukocyte and neutrophil counts, and ex vivo cytokine production capacity was lower in women with CHDMs. Surprisingly, the presence of atherosclerotic plaques was significantly lower in individuals with CHDMs. There was no relation between CHIP and metabolic syndrome.

Conclusions

In individuals with overweight or obesity, CHDMs are not associated with vasculometabolic complications, but rather with a lower presence of carotid plaques. CHDMs associate with increased circulating inflammatory markers and leukocyte numbers, but a lower peripheral blood mononuclear cell cytokine production capacity.
Pediatric Out‐of‐Hospital Cardiac Arrest: The Role of the Telecommunicator in Recognition of Cardiac Arrest and Delivery of Bystander Cardiopulmonary Resuscitation
Authors: Lewis Miranda M. , Pache Killian , Guan Sally , Shin Jenny , Parayil Megin , Counts Catherine R. , Drucker Chris , Sayre Michael R. , Kudenchuk Peter J. , Eisenberg Mickey , Rea Thomas D.
Published: January 2024

Background

Telecommunicator CPR (T‐CPR), whereby emergency dispatch facilitates cardiac arrest recognition and coaches CPR over the telephone, is an important strategy to increase early recognition and bystander CPR in adult out‐of‐hospital cardiac arrest (OHCA). Little is known about this treatment strategy in the pediatric population. We investigated the role of T‐CPR and related performance among pediatric OHCA.

Methods and Results

This study was a retrospective cohort investigation of OHCA among individuals <18 years in King County, Washington, from April 1, 2013, to December 31, 2019. We reviewed the 911 audio recordings to determine if and how bystander CPR was delivered (unassisted or T‐CPR), key time intervals in recognition of arrest, and key components of T‐CPR delivery. Of the 185 eligible pediatric OHCAs, 23% (n=43) had bystander CPR initiated unassisted, 59% (n=109) required T‐CPR, and 18% (n=33) did not receive CPR before emergency medical services arrival. Among all cases, cardiac arrest was recognized by the telecommunicator in 89% (n=165). Among those receiving T‐CPR, the median (interquartile range) interval from start of call to OHCA recognition was 59 seconds (38–87) and first CPR intervention was 115 seconds (94–162). When stratified by age (≤8 versus >8), the older age group was less likely to receive CPR before emergency medical services arrival (88% versus 69%,
P
=0.002). For those receiving T‐CPR, bystanders spent a median of 207 seconds (133–270) performing CPR. The median compression rate was 93 per minute (82–107) among those receiving T‐CPR.

Conclusions

T‐CPR is an important strategy to increase early recognition and early CPR among pediatric OHCA.
Effectiveness of Hypertension Management Strategies in SPRINT‐Eligible US Adults: A Simulation Study
Authors: Zhang Fengdi , Bryant Kelsey B. , Moran Andrew E. , Zhang Yiyi , Cohen Jordana B. , Bress Adam P. , Sheppard James P. , King Jordan B. , Derington Catherine G. , Weintraub William S. , Kronish Ian M. , Shea Steven , Bellows Brandon K.
Published: January 2024

Background

Despite reducing cardiovascular disease (CVD) events and death in SPRINT (Systolic Blood Pressure Intervention Trial), intensive systolic blood pressure goals have not been adopted in the United States. This study aimed to simulate the potential long‐term impact of 4 hypertension management strategies in SPRINT‐eligible US adults.

Methods and Results

The validated Blood Pressure Control–Cardiovascular Disease Policy Model, a discrete event simulation of hypertension care processes (ie, visit frequency, blood pressure [BP] measurement accuracy, medication intensification, and medication adherence) and CVD outcomes, was populated with 25 000 SPRINT‐eligible US adults. Four hypertension management strategies were simulated: (1) usual care targeting BP <140/90 mm Hg (Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure usual care), (2) intensive care per the SPRINT protocol targeting BP <120/90 mm Hg (SPRINT intensive), (3) usual care targeting guideline‐recommended BP <130/80 mm Hg (American College of Cardiology/American Heart Association usual care), and (4) team‐based care added to usual care and targeting BP <130/80 mm Hg. Relative to the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure usual care, among the 18.1 million SPRINT‐eligible US adults, an estimated 138 100 total CVD events could be prevented per year with SPRINT intensive, 33 900 with American College of Cardiology/American Heart Association usual care, and 89 100 with team‐based care. Compared with the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure usual care, SPRINT intensive care was projected to increase treatment‐related serious adverse events by 77 600 per year, American College of Cardiology/American Heart Association usual care by 33 300, and team‐based care by 27 200.

Conclusions

As BP control has declined in recent years, health systems must prioritize hypertension management and invest in effective strategies. Adding team‐based care to usual care may be a pragmatic way to manage risk in this high‐CVD‐risk population.
“A Distinctly Busy Man” – Lieutenant Colonel (Dr) Frederick Holles Brennan, First Officer Commanding of the 1st South African Irish Regiment, 1861–1927
Authors: Snyders Hendrik
Published: January 2024

Lieutenant Colonel Frederick Holles Brennan, formerly the commanding officer of the 1st South African Irish Regiment, medical officer of the Transvaal Volunteers, surgeon to the Hawarden Castle hospital ship and recipient of the Volunteer Officer’s Decoration and Long Service Medal during active service, is a forgotten name in South African military history today. Canadian-born Brennan, a qualified medical doctor, emigrated to South Africa during the 1890s. After settling in Johannesburg, he established a successful medical practice and became an integral part of the Irish-Canadian diasporic community on the Witwatersrand. This was complemented by active involvement in a range of charitable causes, in addition to participating in both the Anglo-Boer War (on the side of the British) and the First World War. From 1894–1927, Brennan made a fundamental contribution to the development of the South African military and sports history, without compromising his Irish-Canadian identity.
Near-Surface Atmospheric Response to Meso- and Submesoscale Current and Thermal Feedbacks
Authors: Conejero Carlos , Renault Lionel , Desbiolles Fabien , McWilliams J. C. , Giordani Hervé
Published: January 2024

Current feedback (CFB) and thermal feedback (TFB) have been shown to strongly influence both atmospheric and oceanic dynamics at the oceanic mesoscale (10–250 km). At smaller scales, oceanic submesoscale currents (SMCs; 0.1–10 km) have a major influence on the ocean’s energy budget, variability, and ecosystems. However, submesoscale air–sea interactions are not well understood because of observational and modeling limitations related to their scales. Here, we use a realistic submesoscale-permitting coupled oceanic and atmospheric model to quantify the spatiotemporal variability of TFB and CFB coupling in the northwest tropical Atlantic Ocean. While CFB still acts as a submesoscale eddy killer by inducing an energy sink from the SMCs to the atmosphere, it appears to be more efficient at the submesoscale by approximately 30% than at the mesoscale. Submesoscale CFB affects the surface stress, however, the finite time scale of SMCs for adjusting the atmospheric boundary layer results in a diminished low-level wind response, weakening partial ocean reenergization by about 70%. Unlike at the mesoscale, submesoscale CFB induces stress/wind convergence/divergence, influencing the atmospheric boundary layer through vertical motions. The linear relationship between the surface stress derivative or wind derivative fields and sea surface temperature gradients, widespread at the mesoscale, decreases by approximately 35% ± 7% or 77% ± 10%, respectively, at the submesoscale. In addition, submesoscale TFB induces turbulent heat fluxes comparable to those at the mesoscale. Seasonal variability in meso- and submesoscale CFB and TFB coupling is mostly related to background wind speed. Also, disentangling submesoscale CFB and TFB is challenging because they can reinforce or counteract each other.