bluuebunny/crossref_metadata_2025 huggingface dataset:
Challenging the Gold Standard Transurethral Resection of the Prostate with Holmium Laser Enucleation in the Treatment of Benign Prostatic Hyperplasia: Paradigm Shift in Northern Cyprus
Authors: Bayraktar Necmi
Published: September 2024

Benign prostatic hyperplasia (BPH) is a common condition among men over the age of 50, which can significantly impact their quality of life. Transurethral Resection of the Prostate (TURP) has long been considered the gold standard for the surgical treatment of BPH because of its effectiveness and integration into urology training. However, in recent years, Holmium Laser Enucleation of the Prostate (HoLEP) has gained popularity owing to reduced bleeding, shorter hospitalization, and faster recovery times. This study aimed to evaluate the transition from TURP to HoLEP among urologists at Burhan Nalbantoğlu State Hospital by analyzing learning curves, complication rates, and patient outcomes. The study results suggest that HoLEP offers several advantages over TURP, including shorter hospital stay and lower postoperative complications, although it requires significant training and investment. Overall, this study supports HoLEP as a promising alternative to TURP, reflecting a shift in the paradigm of BPH management.
Pathophysiology of Sepsis: A Potential Pathway for Defining Distinct Clinical Phenotypes and Potential Targeted Therapies Including Therapeutic Plasma Exchange
Authors: Keith Philip , Conrad Taylor , Eaton Jonathan , Keith Scott Louie
Published: September 2024

Sepsis is now understood to be a syndrome affecting numerous pathways with both damage related patterns and pathogen attributed patterns. It is also becoming clear that there is a phenotypic response to those insults. We now see that sepsis requires patient specific therapy and not just a uniform therapeutic strategy. Therapeutic plasma exchange (TPE) is one phenotypic driven intervention that is being shown to improve clinical outcomes and many different clinical markers in severe cases of sepsis. As our knowledge of these phenotypes progresses, so does our understanding of the use of TPE. This chapter will briefly outline the current understanding of sepsis and begin to define severe sepsis response phenotypes while expanding on the use of TPE as a therapeutic intervention.
Food Legumes for Sustainable Crop Intensification of Rice-Based Cropping Systems: Bolstering Food and Nutritional Security in South Asia
Authors: Kaul Smita , Singh Akanksha , Biradar Chandrashekhar , Kumar Shiv
Published: September 2024

Food legume crops are gaining significant recognition as a crucial option for sustainable intensification of rice fallows in rainfed lowland agroecology, offering substantial potential to enhance food and nutritional security while enhancing soil health and ecosystem services. In South Asia, 22.3 million hectares of fallow land offer opportunities to boost food legume production, nutrition, soil health, and smallholder farmer income by leveraging legumes’ nitrogen-fixing ability and integrating them into cropping systems to improve soil organic carbon and reduce greenhouse gas emissions. Legume-based intensification and diversification have been accompanied by innovations that include short-duration, nutrient-dense, high-yielding varieties that fit well in the rice fallow system. Innovative seed systems, coupled with effective value addition support, market linkages, and intensive extension efforts, are positioned to enable farmers to choose food legumes as a sustainable option for crop intensification and diversification. Despite advancements, challenges such as location-specific innovations and scaling up adoption of modern technologies must be addressed to fully realize the impact of food legumes in cereal-based cropping systems. This chapter highlights the importance of introducing food legumes to sustainably intensify rice-based cropping systems in South Asia, covering existing approaches, potential scope, challenges, and associated socioeconomic and environmental impacts.
An Immersive Collaborative Virtual Environment for Surgical Planning: Project VR-Surgical
Authors: Boulanger Pierre
Published: September 2024

This chapter describes VR-Surgical, an immersive collaborative virtual reality environment designed to assist medical teams to perform surgical planning. This prototype is designed to improve surgical planning between medical teams in both remote and co-located settings. The system makes it possible to define, adjust, and annotate virtual resections of organs’ 3D surfaces and 2D image slices from MRI and CT scans. By integrating Insight Toolkit (ITK) core capabilities with VR-Surgical, it is possible to process, register, and visualize various imaging modalities during the meeting. This chapter discusses the fundamental components of a prototype system and a small pilot usability study conducted by two teams of radiologists and surgeons. It shows significant improvements in time and accuracy of the surgical planning process.
MOOC for lifelong learning: training critical, reflective and self-regulating students at university level
Authors: Enrique Díaz Camacho José , Alejandra Garcimarrero Espino Eli , Núñez Mercado Patricia , Yelní Díaz Oviedo Heidy
Published: September 2024

This project presents a report on the implementation of a course enriched with information and communication technologies aimed at the training of more critical, reflective and self-regulated undergraduate students in a Mexican university. With this objective in mind, this study used the best online teaching practices, as defined in a previous study, applying them in an enriched, supported and technology-based learning environment through online university courses. The instrument developed in the previous project was used to evaluate the teacher’s performance as a measure of educational gain using a statistical correlational methodology. This survey was administered to students from a Mexican university to obtain an account of the best teaching practices and correlate them with student performance. Once the data was collected, the results were analysed and graphed, and the corresponding reports were prepared. It can be concluded that by using appropriate teaching techniques and methods, it is possible to prepare critical, reflective and self-regulating students.
A Time Series Approach to Assess the Impact of the COVID-19 Pandemic on the South African Tourism Sector
Authors: Chipumuro Musara , Chikobvu Delson , Makoni Tendai
Published: September 2024

The chapter examines tourism flows all over the world with a special case of all foreign tourists to South Africa (SA) from January 2009 to December 2023. A time series approach is used, and the model obtained is used to forecast and evaluate the effects of COVID-19 on total tourist arrivals in SA. The model forecasts are used in comparison with actual tourist arrivals after February 2020 when COVID-19 restrictions were employed. Monthly data on arrivals of all tourists to SA was considered. The ARIMA (0,1,1)(0,1,1)12 model was obtained considering its lowest value of the Bayesian Information Criterion (BIC) through the Box and Jenkins methodology. The forecasting power of the model is evidenced by its Mean Absolute Percentage Error (MAPE) of 1.934579. The effects of COVID-19 are realized form the difference in forecasts made and actual figures recorded from March 2020 when COVID-19 restrictions were effected. This study gives an overview of the contribution being realized from tourism receipts through an analysis of tourist arrivals before, during and after the COVID-19 pandemic. This helps inform various tourism stakeholders on how best the tourism sector may be revived through informative forecasts, good planning and policy formulation strategies.
Staging in cervical cancer
Authors: Konal Merve
Published: September 2024

Cervical cancer remains a significant health concern globally, particularly in low- and middle-income countries. Accurate staging of cervical cancer is critical as it directly influences treatment decisions and prognostic assessments. This chapter provides a comprehensive overview of the staging methodologies used in cervical cancer, highlighting the International Federation of Gynecology and Obstetrics (FIGO) and the Tumor, Node, Metastasis (TNM) staging systems. It delves into diagnostic methods, including clinical examination, advanced imaging techniques, and pathological evaluation, and discusses recent advancements such as molecular imaging, biomarkers, and artificial intelligence. The chapter also explores the clinical implications of staging, including its role in treatment planning, prognostic evaluation, and follow-up care. Additionally, it addresses the challenges and future directions in cervical cancer staging, emphasizing the importance of emerging technologies and personalized medicine approaches. By enhancing the accuracy of staging, these advancements aim to improve patient outcomes and quality of life for those affected by cervical cancer.
Data-Mediated Environments: Reality after the Metaverse
Authors: Heemsbergen Luke
Published: September 2024

This chapter examines augmented reality (AR) not as a mere visual overlay of the virtual on the real but as fundamentally relational media between compute and environment. It does so to build toward a definition of the metaverse as media that perceive and persistently relate the physical world with computed data. Tracing mediation technologies (from print to metaverse) that continually shape our reality, this chapter critiques current electro-atomic divides tied to a continuum of virtuality and reality. This chapter explores how a relational understanding of compute and environment constructs and mediates perceivable reality by drawing from foundational concepts like Milgram and Kishino’s continuum, modern works of art and product-science that Extend Reality, and the philosophy of Karen Barad. Understanding the augmentation of reality through this relational, integrative perspective is crucial for not only developing precision of what the metaverse is but also accurate understanding for experiencing and regulating the futures of connection that the metaverse offers.
Application of infrared spectroscopy in the field of tumor
Authors: Chen Luobei , Zhu Kejing
Published: September 2024

Cancer is currently the leading cause of death in countries and an important obstacle to extending national life expectancy. Due to the delayed reporting of results and the delay of patient care caused by the current medical workflow, the result will affect the treatment and prognosis of patients and bring potential economic burden to medical institutions. The development of novel, low-cost, and rapid diagnostic platforms is the key to breaking through the current diagnosis and treatment dilemma. The potential of infrared (IR) spectroscopy as a powerful clinical tool is very clear, as can be seen from countless proof-of-principle studies with high specificity and sensitivity for disease detection and classification. Therefore, for cancer screening, rapid detection, simple operation, low cost, and alternative or auxiliary diagnostic technology infrared spectroscopy has important potential.
Perspective Chapter: Targeting the Myeloid Compartment – Innovative Immunotherapy Strategies for Malignant Brain Tumors
Authors: Christine Kienzler Jenny
Published: September 2024

This chapter explores the complex immune landscape of malignant brain tumors and the potential of immunotherapy in their treatment. It focuses on the predominant role of tumor-associated macrophages in the tumor microenvironment, including monocyte-derived macrophages, microglia, and border-associated macrophages. We discuss the results of various immunotherapy trials, including immune checkpoint blockade. While some approaches have shown promise, particularly in brain metastases, many have faced challenges in improving patient outcomes, especially in glioblastoma. The section highlights the importance of understanding the diverse functions of myeloid cells in the tumor microenvironment and proposes strategies for targeting these cells. Finally, we emphasize the need for more comprehensive research on the macrophage niche to develop effective immunotherapies for malignant brain tumors, potentially revolutionizing treatment approaches in this challenging field.
PROSPECTIVE DESIGNS OF RECOVERABLE SUSPENSIONS OF TRAILER LINKS OF LOGGING ROAD TRAINS
Authors: Posmetev Valeriy , Nikonov Vadim , Avdyuhin Aleksandr , Siz'min Igor , Matyashov Aleksey
Published: September 2024

The article considers specific features and consequences of operation of timber road transport when driving in difficult natural and climatic conditions on logging roads with insufficient level of development. The necessity of increasing the efficiency of timber removal by logging road trains by using recuperative shock absorbers in the designs of their trailer links is substantiated. The article describes the operation of the proposed schemes of recuperative hydraulic drives, allowing suspension shock absorbers to convert and accumulate the energy of the working fluid during the movement of logging road trains on uneven logging roads.
Strategie učení cizího jazyka při kooperativním učení metodou eduscrum: přehledová studie
Authors: Hlavicová Anna
Published: September 2024

This literature review study aims to summarize current research on foreign language learning strategies and offers a structured perspective on issues related to the topic of the dissertation research, which will investigate cooperative language learning using the eduScrum method with focus on learning strategies. The results of the research show what learning strategies students use during foreign language learning. The study focuses on learning strategies at different levels of education, from primary to higher education.
Training Tomorrow’s Journalists: An Analysis of Student Newspaper Content
Authors: Schmidt Hans C. ,   Pennsylvania Communication Association
Published: September 2024

The changing nature of media and journalism has heightened the importance of quality journalism education and the hands-on experience that students gain while working at campus newspa-pers. To better understand what skills journalism students are developing, this study involved a content analysis of six of the nation’s top student newspapers and a survey of student newspa-per staff members across the country. Results demonstrate that student journalists cover certain topics frequently, neglect other topics, and use limited sources.
Women Leaders in Higher Education: Constructing an Active Voice
Authors: McKenzie Kelly Lynch , Halstead Tammy J. ,   Pennsylvania Communication Association
Published: September 2024

Despite a substantial increase in the number of women with advanced degrees in higher education, women leaders remain un-derrepresented in top leadership positions. This continued un-derrepresentation in numbers and status indicates that having more women in the university pipeline is not enough to improve the leadership status of women in higher education. Therefore, a fundamental change is needed in the approach that women take when considering and pursuing leadership positions. This quali-tative study proposes that an essential component of this change should be an increase in women’s use of an “active voice” on college campuses. This study investigates how seven successful women leaders in higher education have constructed and imple-mented an active voice in developing their own leadership skills, and advancing opportunities for future women leaders, despite barriers that traditionally impede leadership attainment for wom-en in higher education. Collectively, the stories of the seven women leaders depict higher education as a complex environment in which women struggle not only for equality, but also for their voices to be heard by both men and women.
Exploring the Pattern of Coursera Network onTwitter: How Far Are MOOCs Reaching Out?
Authors: Tu Haijing ,   Pennsylvania Communication Association
Published: September 2024

Simultaneous to Massive Open Online Courses (MOOCs) crossing cul-tural and geographical boundaries, their dissemination across social networks is intensifying. This research thus first maps the path of the spread of MOOCs using Coursera’s Twitter account and explores the characteristics of this particular social network. Further, by conducting a social network analysis of the hashtag discussions about MOOCs, this research explores just how far-reaching MOOCs actually are. The research finds the Twitter network of Coursera to be loosely connected with a low closeness centrality and a high betweenness centrality. Because the pattern of this network shows that subjects (nodes) in the network are not clustered around the Coursera account, no obvious threshold was identified that plays a key role in its cascading of information. At the same time, the thematic discussion on MOOCs demonstrates a pattern in which relatively few influential players dominate the discussion, and the network is centralized around these dominant players without much interactivity between ordinary users with less influence.
Interruptions and Gender in TV Political Commentary
Authors: DeGerlia Allison May ,   Pennsylvania Communication Association
Published: September 2024

This research extends the work done by West & Zimmerman (1983) and Zhao & Gantz (2003) to examine gender differences in interruptions on non-fictional political television program-ming. The goal was to find out if the findings of previous re-search, namely that males interrupt more and more disruptively than females, apply to group cross-sex talk among professionals, as well as to learn if age and political affiliation might be rele-vant to interruptions. A sample of approximately 40 minutes of cross-sex talk of the HBO TV show Real Time with Bill Maher was recorded from three different episodes and transcribed using Jefferson’s transcription method. The findings showed that wom-en were more likely to be interrupted and with more disruptive interruptions. In addition, women were interrupted at a higher frequency and on average talked less. It was also found that the age of the women correlated with the amount of interruptions, the way they were interrupted, and the amount of talk. Implica-tions of these findings are discussed.
Even The Strongest Have Weaknesses
Authors: Shepard Gretchen Frances ,   Pennsylvania Communication Association
Published: September 2024

This oral history interview with a Salt-Wasting Adrenal Hyper-plasia patient demonstrates the importance of direct physician/patient communication with parents as well as with their under-aged children. Throughout the interview, I found that there were positive and negative interactions that suggested a need for im-proved medical communication training. The most significant was the lack of communication between the patient, who was di-agnosed at birth, and the medical professionals. Earlier research shows that most people believe that children are not interested in their medical treatment, but newer studies have found that this is not the case. The patient narrator stated that the doctors would not communicate to him but rather only to his parents, who did not have enough background to understand the medical terminol-ogy used. This caused them to leave the appointment confused. Since this was an era before the internet, they were unable to Google any questions or words they did not understand. This left him and his parents in the dark when it came to his medical treat-ment. Although that was over 40 years ago, I believe this problem still exists in the medical scene today. Although there has been some communication improvement, the evidence uncovered in this interview suggests that medical communication training is needed to improve upon how medical students deal with younger patients.
OVERVIEW OF INTESTINAL COCCIDIAN PARASITES IN HUMAN BEINGS
Authors: Prakash Dr. Vidyut
Published: September 2024

Intestinal Coccidian parasites are a group of protozoan parasites belong to phylum Apicomplexa ,class coccidea , family Eimeriidae. [Table-1] Some of the common intestinal coccidian parasites that infect humans include Cryptosporidium spp., Cyclospora cayetanensis, and Isospora spp. The importance of intestinal coccidian parasites in immunocompromised patients lies in the increased risk of severe disease and the potential for opportunistic infections. In immunocompetent individuals, infection with intestinal coccidian parasites may cause self-limiting symptoms such as loose stool, pain abdomen, nausea and vomiting. However, in immunosupressed individuals , such as those with HIV/AIDS, organ transplants, or undergoing chemotherapy, these infections can lead to severe and potentially life-threatening complications. Immunocompromised individuals are more susceptible to developing chronic and disseminated infections with intestinal coccidian parasites. The parasites can cause prolonged diarrhea, malabsorption, weight loss, dehydration, and electrolyte imbalances in these patients. Additionally, coccidian parasites may lead to extra intestinal manifestations, such as biliary tract involvement or systemic dissemination, leads to significant morbidity and mortality in immunocompromised individuals. Monitoring and managing coccidian parasite infections in immunocompromised patients are crucial to prevent complications and improve clinical outcomes. Strategies for prevention, early detection, and treatment of coccidian parasite infections are essential in this vulnerable patient population.
MONOCLONAL ANTIBODIES: A PROMISING WEAPON AGAINST THE SILENT PAN-DEMIC OF MULTIDRUG-RESISTANT BACTERIA
Authors: Jana Manoj Kumar , Chiang Ming-Hsien
Published: September 2024

The global threat of antimicrobial resistance (AMR) has reached critical levels, presenting an unprecedented challenge to public health and economic stability worldwide. (Cassini et al., 2019; CDC, 2019). Recent data paint a stark picture: annually, AMR is responsible for an estimated 1.27 million deaths globally, with projections suggesting this could rise to 10 million by 2050 if current trends persist (O‘Neill, 2014). In the United States alone, more than 2.8 million antibiotic-resistant infections occur each year, resulting in over 35,000 deaths (CDC, 2022). The COVID-19 pandemic has further exacerbated this crisis. Despite guidelines recommending against routine antibiotic use for SARS-CoV-2 infections, a comprehensive study revealed that nearly 75% of COVID-19 patients received prophylactic antibiotics, even though only 8.6% had confirmed bacterial co-infections (Langford et al., 2021). This widespread misuse of antibiotics has accelerated the development of resistance. Following the peak of the pandemic, the U.S. Centers for Disease Control and Prevention reported a alarming 15% increase in hospital-acquired antimicrobial-resistant infections (Antimicrobial Resistance, 2022). Particularly concerning is the rise in resistant strains of common pathogens, including MRSA, VRE, MDR Pseudomonas aeruginosa, and carbapenem-resistant Acinetobacter, which collectively account for a significant proportion of AMR-related deaths.
ARTIFICIAL INTELLIGENCE AND BIG DATA ANALYSIS
Authors: Pandey Neha
Published: September 2024

Artificial Intelligence (AI), a dynamic discipline within computer science, stands as a driving force in simulating intelligent behaviors in machines. In the specialized realm of medical microbiology, AI systems leverage the capabilities of machine learning algorithms to navigate extensive datasets, unravel intricate patterns, and conduct predictive analyses. This sophisticated application of AI is pivotal, not only amplifying our comprehension of microbial interactions but also furnishing crucial insights into the intricate landscape of infectious diseases (Goodswen et al., 2021; Shelke, Badge, & Bankar, 2023; Bellini et al., 2022). The scope of AI in medical microbiology transcends conventional methodologies, presenting a revolutionary paradigm for unraveling microbial complexities. Through the analysis of genomic, proteomic, and clinical data, AI systems contribute significantly to a more holistic understanding of infectious diseases. These systems showcase the ability to discern subtle patterns indicative of specific microbial strains, forecast disease trajectories, and pinpoint potential drug targets (Goodswen et al., 2021; Shelke, Badge, & Bankar, 2023; Bellini et al., 2022).
AN OVERVIEW OF URINARY TRACT INFECTION
Authors: Sarkar Dr. Rajesh , Wondwosen Dr. Biniyam , Fikru Dr. Abdi , Shume Tadesse
Published: September 2024

The urogenital tract is the union of the reproductive and urinary tract systems. Both systems are susceptible to disease because of their openness to the external environment. Among the most prevalent bacterial infections, urinary tract infections (UTIs) impact 150 million individuals globally (Mlugu et al., 2023). Uropathogenic E. Coli (UPEC), the most frequent cause of UTIs, can form a biofilm associated with antibiotic resistance (AMR) (Mlugu et al., 2023). A microbiome that is out of balance can cause some infections, while external exposure can cause others (Kim and Lee, 2023). When STIs traverse the reproductive organs, they can result in severe morbidity and reduced fertility. Due to variations in urogenital anatomy, males and females may be affected by urogenital infections in different ways (Van Gerwen, Muzny, and Marrazzo, 2022). Although both men and women can have infections, UTIs are more common in women, with approximately 50% of cases happening in women throughout their lives (Health Exchange, 2024).
CAMPYLOBACTER
Authors: Smith Margaret Ordonez
Published: September 2024

Campylobacter is in the family of Campylobacteraceae. In 1963 E. J M. Sebald and M. Veron discovered it and was classified as a Vibrio. There are 24 species that affect humans and animals (73,75,103,117)
VIRUSES CAUSING HUMAN DISEASES
Authors: Das Dr. Priti
Published: September 2024

Epidemiology studies the distribution and dynamics of diseases and factors influencing their occurrence in populations. It examines how virus characteristics, host susceptibility, and environmental factors impact infection risk. By analyzing quantitative data, virus epidemiology seeks to understand disease patterns, identify outbreak sources, develop prevention strategies, and explore the role of viruses in disease. It also aids in evaluating transmission modes and testing vaccines and treatments on a large scale.
A CLINICAL CASE STUDY TO EVALUATE THE EFFICACY OF VIDDHA AGNI KARMA IN GRIDHRASI W.S.R TO SCIATICA SYNDROME
Authors: Ranjan Madhu , Meghana Ms
Published: September 2024

Gridhrasi (Sciatica Syndrome) is one of the Vatavyadhi and the most prevalent disorders that affects the lower limb and causes morbidity throughout the productive years of life, making it difficult to walk. It is characterized by pain, stiffness, and recurrent twitching sensation felt along the course of sciatic nerve in the buttocks, low back, thighs, back of knee, calf region, and foot, along with restricted movement of the affected body parts, as it is caused by aggravated Vata Dosha. If the disease is caused by both Vata and KaphaDosha, it results in drowsiness, heaviness and anorexia as additional symptoms. Sciatica Syndrome have become a disorder with a high prevalence, estimated to have 10 million cases reported annually from India. Especially in the 40–60year age group in males. Both Acharya Sushruta and Acharya Charaka mentioned AgnikarmaChikitsa in the management of Gridhrasi (Sciatica Syndrome) at the site of Antara-Kandara-GulphaPradesha. Considering these, in present study Gridhrasi was treated with Viddha Agni Karma and the results were evaluated for the study at each stage.
OVERVIEW OF SOIL EROSION
Authors: Vimalananth T , Ramaswamy Muthu Dinesh Kumar , Kumar P. Arun
Published: September 2024

Soil, a complex and dynamic natural resource, plays a pivotal role in supporting terrestrial ecosystems and providing essential services to humanity. This abstract delves into the multifaceted nature of soil by exploring its composition, properties, and functions, highlighting its critical importance in sustainable land management. The composition of soil involves a heterogeneous mixture of mineral particles, organic matter, water, air, and various microorganisms. The interactions between these components give rise to distinct soil horizons, each with its unique characteristics that influence soil's physical, chemical, and biological properties.
NON ALCOHOLIC FATTY LIVER DISEASE (NAFLD) - AN EMERGING & HIDDEN DISEASE IN ALMOST ALL
Authors: Sedhunivas Dr R.
Published: September 2024

Non-alcoholic fatty liver disease is becoming prevalent in India and all around the world due to faulty food style and low physical activity. This chapter provides a deep insight into the Non-alcoholic fatty liver disease on the causes, symptoms and path physiology thus a deep comprehensive cover on the topic. Physiotherapy exercises and testing is been described in the shorter format for the easy understanding.
FUTURISTIC TRENDS IN DIAGNOSTIC AND MOLECULAR MICROBIOLOGY
Authors: Bhattacharyya Dr. Sayan
Published: September 2024

Diagnostic microbiology has evolved very fast over the last few decades. Now many advanced techniques are available in the armamentarium of the laboratory scientist, which save time and provide sensitive and specific results. Most of these advanced techniques are available in medical bacteriology and mycology, but medical virology is also witnessing rapid advancements. The authors will elaborate these in this chapter. However the interested reader is also referred to the references listed at the end of this chapter for developing a more holistic notion of this subject.
Combination of structural and functional ophthalmological and radiological methods for differentiating normal-tension glaucoma: clinical case
Authors: Rozhko A. A. , Gazizova I. R.
Published: September 2024

Glaucoma is only partially associated with increased intraocular pressure. Normal-tension glaucoma (NTG) is a form of open-angle glaucoma in which optic nerve damage and visual field defects are present despite a baseline intraocular pressure of less than 21 mmHg. The exact mechanism by which anatomical and functional damage occurs remains unknown in patients with NTG. The proposed theories, mechanical and vascular, do not fully explain the pathogenesis of the disease. This dictates the need to perform both structural and functional ophthalmological and radiological diagnostic methods in differentiating the diagnosis. The authors analyzed a clinical case of NTG in 66-year-old patient over 3-year period of the disease. The results presented in the article allow us to conclude that traditional ophthalmological examinations remain relevant. Energy metabolism and dysfunctional neurodegeneration metabolic pathways play a role in the pathophysiology of NTG. The role of cerebral glucose metabolism is not fully understood and requires study in NTG. It may provide clinicians with additional opportunities for diagnosing and treating the disease.
Etiology and pathogenesis of pelvic floor dysfunction (literature review)
Authors: Murashko O. V. , Podgornaya A. S. , Zakharko A. Y.
Published: September 2024

Pelvic floor dysfunction (PFD) in women includes conditions such as vaginal relaxation syndrome (VRS), pelvic organ prolapse (POP), urinary and fecal incontinence, obstructed defecation, and sexual dysfunction. Etiopathogenesis is associated with disorders of the pelvic floor fixing apparatus that arise due to traumatic childbirth, genetic changes in the structure of connective tissue (polymorphism of the gene for connective tissue enzymes NAT2). Techniques used to diagnose pelvic floor injuries include x-rays, computed tomography, magnetic resonance imaging (MRI), and ultrasound. In this publication, we presented an overview of the most relevant and recent data on the etiopathogenesis, diagnosis of DTD.
Smooth muscle tumors of uncertain malignant potential (STUMP): current state of the problem
Authors: Zaharko A. Yu. , Podgornaya A. S. , Murashko O. V. , Zhandarov М. Yu. , Rombalskaya A. R.
Published: September 2024

The most common type of uterine tumors are smooth muscle tumors: benign leiomyomas, smooth muscle tumors of uncertain malignant potential (STUMP), sarcomas. The incidence of STUMP is difficult to estimate. They account for 1,3% of all uterine malignancies. A thorough histopathological examination is necessary to confirm the correct diagnosis of STUMP due to the unreliability of preoperative imaging techniques for differentiating between leiomyoma, STUMP and leiomyosarcoma. Compared with sarcomas, STUMP have a better prognosis, but their biological potential is uncertain because recurrence, malignancy, and metastasis are possible many years later. Considering the rarity of tumors with uncertain malignant potential, the small number of publications on their treatment, there are no clinical recommendations for the management and treatment of patients with this pathology. The article reviews current data on the diagnosis and differential diagnosis of smooth muscle tumors, management tactics, treatment, and prognosis of patients with STUMP.
Embryotoxic effect of experimental dark deprivation
Authors: Sobolevskaya I. S. , Pashinskaya E. S. , Pashinskaya A. K. , Ignateva I. V. , Pobyarzhin V. V. , Sedlovskaya S. M. , Sobolevsky S. L. , Yashkina A. V.
Published: September 2024

The article presents the results of fundamental research into the effect of dark deprivation on female rats during pregnancy. Dark deprivation leads to a decrease in the number of living embryos by 3,4 times, 3,1 times and 3,3 times on the 7th, 14th and 21st days. A decrease in the average weight of embryos was revealed by 1.9 times on the 7th day, by 1.5 times on the 14th day and by 1.8 times on the 21st day.

A significant decrease in the average craniocaudal size of embryos in the experimental group was recorded. This indicator decreased by 2,7 times on the 7th day, by 1,8 times on the 14th day and by 1,8 times on the 21st day. Preimplantation death due to chronodestruction showed an increase of 4,3 times relative to the control at the final stage of the study (day 21). There was an increase in post-implantation death under the influence of constant light on the 7th day to 70,51%, on the 14th day – to 68,26%, on the 21st day – to 69,71%.

The findings may have important translational implications and will be used to find effective methods to prevent complications in pregnant women with disrupted circadian rhythms.
AS PRÁTICAS PEDAGÓGICAS FRENTE À APRENDIZAGEM DO ALUNO COM DEFICIÊNCIA
Authors: Ferreira Eladio
Published: September 2024

O presente artigo foi pensado e construído na tentativa de contribuir na prática pedagógica de professores, que muitas vezes se veem despreparados e incapazes de ensinar alunos com deficiência, propondo- lhes reflexões em torno de suas ações educativas frente à inclusão do aluno com deficiência no ensino regular. Por isso, é crucial discutirmos sobre algumas técnicas de ensino, defendidas por autores da educação que podem servir como auxilio do professor no ato de ensinar a fim de se promover uma mudança de atitudes em relação aos conceitos do que seja a inclusão, permitindo que o educador favoreça a seu educando um espaço acolhedor, em que o aprender se faça em todas suas manifestações, sejam elas intelectuais, sociais, culturas e físicas pra que estes sejam reconhecidos e valorizados nas suas diferenças.
O impacto do Programa Ensino Médio Inovador sobre as proficiências do Sistema de Avaliação da Educação Básica (SAEB) em Santa Catarina
Authors: Abregú Marcos Ezequiel , Romanello Michele
Published: September 2024

O objetivo do artigo é avaliar o impacto do programa ensino médio inovador sobre a proficiência em língua portuguesa e matemática do Sistema de avaliação da educação básica dos alunos do terceiro ano do ensino médio no ano de 2019 em Santa Catarina. Para conseguir esse objetivo a metodologia utilizada é quantitativa: o método quase experimental do pareamento por escore de propensão (PSM) é aplicado utilizando os dados do SAEB. 
Após a aplicação do pareamento com escore de propensão, foram identificados um efeito não significante estatisticamente sobre a proficiência em língua portuguesa e um positivo, significante estatisticamente, de 11,33 pontos sobre a proficiência em matemática.
De acordo com esses resultados, o Ensino médio inovador não apresenta efeitos sobre a proficiência em língua portuguesa, enquanto, por outro lado, proporciona um efeito positivo sobre a proficiência em matemática. O programa precisa assim expandir o esforço para ampliar os conhecimentos na área de língua portuguesa e humanística in geral. Ainda que não seja um dos objetivos do ProEMI, esse resultado poderia ser facilmente alcançado, considerando que alguns dos objetivos do ProEMI, como a ampliação do tempo dos estudantes na escola integral e a interdisciplinaridade, podem incentivar a aprendizagem na área de língua portuguesa.
Restaurantes verdes: relato de experiência de oficinas sustentáveis em restaurantes comunitários
Authors: Miranda Priscila Cortes do Prado , Maynard Dayanne da Costa , Almeida Andrea Gonçalves de
Published: September 2024

Os restaurantes sustentáveis baseiam-se na implementação de uma gestão ambiental e estão intimamente relacionados à gestão da qualidade por meio de um conjunto de instrumentos e programas, que visam proporcionar um processo de mudança organizacional e melhoria contínua da qualidade ambiental dos serviços e produtos. Com o objetivo de implantar um programa de desenvolvimento sustentável que transforme restaurantes comunitários em unidades sustentáveis, este estudo de intervenção foi realizado em 12 restaurantes comunitários do Brasil. Foram realizados quatro encontros em cada um dos doze restaurantes comunitários para realizar oficinas sustentáveis. As oficinas sustentáveis mostraram um efeito positivo na conscientização das empresas e dos funcionários em relação às práticas sustentáveis e 100% dos entrevistados responderam que essas práticas foram importantes e geraram reflexão e mudanças entre os funcionários.
Relato de experiência sobre o etnoturismo em Roraima como alternativa sustentável para autogestão
Authors: Cavalcante Jordana de Souza
Published: September 2024

O relato de experiência descreve a vivência realizada na comunidade indígena Raposa I, localizada na terra indígena Raposa Serra do Sol (TIRSS), em Normandia/Roraima. A visita técnica foi realizada em parceria do Instituto Federal de Roraima com a comunidade e teve por objetivo propiciar aos acadêmicos do Curso de Tecnologia em Gestão de Turismo e Pós-graduação do IFRR/Campus Boa Vista a experiência.  O relato compartilha a experiência vivida na comunidade citada, durante uma viagem de visita técnica a um projeto piloto de etnoturismo conforme plano de visitação segundo instrução normativa da FUNAI, que regulariza etnoturismo em terras indígenas. Para descrever o relato, a autora realizou observação direta, descrição de relatos em diário de bordo, além de registros de fotos e imagens da experiência no evento Panela de Barro, em novembro de 2019 na comunidade. Além disso, em janeiro de 2023, o plano recebeu a carta de anuência da FUNAI, sendo a primeira comunidade indígena de Roraima a ter etnoturismo.
Pengaruh Adsorben Karbon Aktif Dan Bleaching Earth (Be) Terhadap Kemurnian Stearin Miniplant Politeknik Kampar
Authors: Khairiah Hanifah , Sihotang Antonius
Published: September 2024

The use of chemical fertilizers that are not equalized with organic fertilizers can damage the soil fertility and it is not environmentally friendly, because the microorganisms which have a role in decompose process will not develop. On the other hand, the high prices of organic fertilizers make farmers reluctant to use organic fertilizers. To solve this problem, farmers could be used microorganism with culturing process. The purpose of this research is to determine the comparison of EM4 with culturing process and EM4 in commercial liquid organic fertilizer that applied in mustard plants. This study used a completely randomized design with three treatments, where the treatment was explained as P0 (control), P1 (EM4 commercial), P2( EM4 by culturing process ). The data were taken in the form of plant height, leaf width, and number of leaves of mustard plants. The conclusion of this study was the application of EM4 with culturing process can accelerate the growth of new leaves, the length and width compared with commercial EM4 and control plants.
Optimalisasi Pengelompokkan Data Produksi Kelapa Sawit Menggunakan Algoritma K-Medoids
Authors: Nasari Fina
Published: September 2024

Kelapa sawit merupakan salah satu tanaman yang banyak dikembangkan diarea perkebunana di provinsi Riau. Luas area dan produksi kelapa sawit provinsi Riau menjadi salah satu yang tertinggi diindonesia. Penyebaran perkebunana kelapa sawit yang hamper diseluruh kabupaten/kota diprovinsi riau, perlu adanya pengelompokkan daerah berdasarkan jumlah produksi. berdasarkan akurasi dan eksekusi  algoritma k-medoids lebih baik dari algoritma k-means dalam pengelompokkan data. Tujuan dari penelitian ini adalah mengelompokkan daerah produksi kelapa sawit dengan dalam 2 kelompok, 3 dan 5 kelompok. Dari hasil pengelompokkan tersebut akan dilihat kelompok terbaik berdasarkan nilai DBI terkecil. Hasil penelitian untuk jenis 2 kelompok diperoleh hasil 7 data pada kelompok 1 dan 5 data pada kelompok 2. Untuk jenis 3 kelompok diperoleh hasil 5 data pada kelompok 1, 4 data pada kelompok 2 dan 3 data pada kelompok 3, sedangkan jenis 5 kelompok diperoleh hasil 3 data pada kelompok 1, 2 dan 4, 1 data pada kelompok 3 dan  2 data pada kelompok 4. Berdasarkan nilai DBI diperoleh jenis kelompok 2 menjadi jenis kelompok terbaik dengan nilai DBI -159796492242,667.
Perancangan Sistem Ppic Guna Mengoptimalkan Proses Produksi Cetak Cover LKS (Lembar Kerja Siswa) Di CV Madyotomo
Authors: Thaufik Kurniawan  , Febrina Agusti  , Ringgo Ismoyo Buwono
Published: September 2024

Printing is an industry that is constantly evolving and adapting to changing market demands, as well as an increasing focus on sustainability. CV Madyotomo is a company engaged in the printing sector. When excessive incoming orders cause a buildup of print orders of up to 110% of production capacity, this makes employees often have to do overtime. The purpose of this research is to design a PPIC system that is useful for planning and scheduling production so that the entire production process can run smoothly and employees don't have to work overtime too often. PPIC system design can be done using Forecasting with the moving average method and single exponential smoothing. From this research, the results of the forecasting methods used for each level are different. For elementary school level (Elementary School) using the Moving Average method. For junior high school level (junior high school) using the single exponential smoothing method. For SMA level (High School) using the single exponential smoothing method. For MPS (Master Production Schedule) production, the number of daily print orders that must be fulfilled is 78,095. The proposed overtime with MPS in 9 days totals 36 hours. The difference in the frequency of company overtime with overtime according to MPS is as much as 28 hours, this of course will also affect the expenses for the wages paid, of course it will be less than before.
Perencanaan Bahan Baku Cat Leatherpaint Menggunakan Metode Material Requirement Planning
Authors: Horasman Purba  , Andung Jati Nugroho
Published: September 2024

PT. Yogyakarta Art Creations is an industry that produces paint, shoes, jeans, which are divided into two materials, foam and canvas. This company has two types of shoe paint which are produced, including types of paint made from canvas and paint made from leather with various colors. The raw materials needed in the manufacture of these paints include water, color pigments, paint reinforcers, paint fasteners and special mixtures for make canvas paint and leather. in each period of one month there can be up to 700 pcs of products with different types of products, with a total income of IDR 125,000,000 each month. However, from February 2023 to March 2023, the company experienced a swelling of raw materials that did not match the predetermined data, so it was necessary to plan shoe polish production in order to determine the appropriate supply of raw materials for each period. The Material Requirement Planning (MRP) method is used to determine what materials or components must be made or purchased, how much is needed and when it is needed. Based on research that has been carried out through several data processing, it can be concluded that raw material inventory control is carried out by forecasting based on past data requests (February 2022 to March 2023) and then the lotting technique used to assist the MRP calculation process is the Method Lot for lot (LFL), Economic Order Quantity (EOQ), and Period Order Quantity (POQ).
Analisis Manajemen Persediaan Bahan Dengan Material Requirements Planning Metode Lot Sizing (Studi Kasus : PT Madubaru PG Madukismo)
Authors: Duta Ariana  , Suseno
Published: September 2024

PT Madubaru PG Madukismo is one of the sugar companies in Padokan, Tirtonirmolo, Kasihan, Bantul, Yogyakarta. In its production needs in one process the production machine covers a capacity of 30,000 quintals per day. The need for sugar for consumers per month is 11,816 tons with sugarcane as much as 164,165 tons, but because PT Madubaru Madukismo has limited land available only 230,000 tons, the company takes from farmers directly to meet its production capacity. In 1 truck, the average can load 56 quintals / truck, it also depends on the condition of the truck and the condition of the sugarcane. from June to November 2022, there was a shortage of raw material stocks of 754,990 tons and a shortage of additional materials of 301,595 liters from June to November from the need for use of 361,914 liters. So using engineering techniques in Material Requirement Planning can be used in planning the amount and scheduling of raw material needs in the company, because it can produce two very important decisions, namely in the form of lots to be ordered and when is the right time to place an order. Techniques that can be used for raw material scheduling, one of which is by using the Material Requirement Planning (MRP) method or raw material inventory planning system, Economic Order Quantity (EOQ) and Period Order Quantity (POQ) where from these methods which is more effective for determining future raw material scheduling.