bluuebunny/crossref_metadata_2025 huggingface dataset:
EFISIENSI BAITUL MAL WA TAMWIL (BMT) DI SURABAYA TAHUN 2012-2017 DENGAN DATA ENVELOPMENT ANALYSIS (DEA)
Authors: Valencia Kirana Rosadhillah  , Fatin Fadhilah Hasib
Published: November 2022

Penelitian ini bertujuan untuk mengetahui apakah BMT di Surabaya sudah mencapai tingkat efisiensi dalam kegiatan operasional nya dari tahun 2012-2017 atau belum. Penelitian ini menggunakan pendekatan kuantitatif. Teknik analisis yang digunakan adalah Data Envelopment Analysis. Penelitian ini menggunakan data primer dimana secara langsung mengambil data laporan keuangan BMT dari pihak BMT tersebut. Hasil penelitian menunjukkan bahwa nilai efisiensi dari hasil pengolahan VRS lebih tinggi dibandingkan hasil pengolahan CRS. Pada asumsi CRS dan VRS, secara keseluruhan BMT di Surabaya belum efisien dari tahun 2012-2017 dan BMT di Surabaya berada pada skala disekonomis, yaitu BMT di Surabaya belum mampu secara optimal dalam memberdayakan sumberdaya nya (input) untuk menghasilkan output sehingga BMT di Surabaya harus melakukan perbaikan dalam mengelola input agar dapat meningkatkan nilai efisien nya dan berada pada skala efisien.
Dental Health Knowledge Improvement about Malocclusion After Oral and Dental Health Empowerment at Miftahul Ulum Melirang Islamic Junior High School, Melirang Village, Bungah District, Gresik
Authors: Ardani I Gusti Aju Wahju , Narmada Ida Bagus , Rahmawati Dwi
Published: November 2022

Background: Malocclusion is one of dental health problem that may affect the oral health in adolescences. The dental health education delivered is expected to be able to change the dental health behaviour of individuals or communities from unhealthy to healthy behaviour. Purpose: To increase knowledge of oral health, especially the level of knowledge of malocclusion by means of empowerment of dental health knowledge at Madrasah Tsanawiyah Miftahul Ulum Melirang Junior High School, Gresik. Methods: A total of 100 junior high school children from grade tenth, eleventh, twelfth were included in the study. Data was collected by instructing participants to fill out a pre-test questionnaire on Google drive, then a teledentistry was conducted and ended by filling out a post-test questionnaire to determine the increase in oral health knowledge for evaluation of dental health empowerment. Results: The main level of knowledge of dental and oral health is good (50%), moderate (40%) and low (10%). Knowledge about dental malocclusion is only 40% who have good knowledge about malocclusion, others are low enough to reach 20% knowledge and other respondents have moderate 40%. After the dental health empowerment program, the knowledge of the participant regarding the oral health was enhanced. Conclusion: the dental and oral health empowerment was performed successfully that increased the level of knowledge of children and teachers is still less than optimal about knowledge of malocclusion, so it is necessary to carry out socialization actions regarding the impact of malocclusion.
Sialorrhea with Neurological Diseases in Oral Medicine Fields: A Narrative Review
Authors: Ernawati Diah Savitri , Pasaribu Togu Andrie Simon
Published: November 2022

Background: Sialorrhea also known as drooling, literally means excessive saliva flow. In patients with neurological conditions such as Parkinson’s disease, cerebral palsy, and stroke. drooling or sialorrhea conditions can be a problem in their lives. In patients with neurological disorders, they experience impaired coordination of facial and mouth muscle movement. Purpose: To describe a review comprehensive management of sialorrhea in neurological, then quality of life can be improved. Reviews: literature search was done thorough literature search between 2008-2020 was done using Science direct, Pubmed and Google Scholar. Conclusion: Treatment for sialorrhea includes non-medical therapy, medical therapy, botulinum toxin, radiotherapy and surgical treatment. Oral medicine specialist dentists have a role in the care of sialorrhea patients with neurological disorders in terms of oral care related as a result of sialorrhea such as perioral dermatitis.
WOMEN’S AUTONOMY AND UNINTENDED PREGNANCY: AN IDHS 2017 DATA ANALYSIS
Authors: Naibaho Margareth Maya Parulianta , Fajarningtiyas Desy Nuri , Arifa Riza Fatma , Pancanugraha Andi
Published: November 2022

Unintended pregnancy impacts hugely on maternal and child health. This study aimed to examine the influence of women’s autonomy on unintended pregnancies including unwanted and mistimed pregnancies. Using the Indonesia Demographic and Health Survey (IDHS) 2017, this study analyzed 12,624 currently married women who had birth within five years preceding the survey. Women’s autonomy was constructed from several variables related to women’s decision on obtaining health care, visiting family, and spending large household purchase. The result of logistic regression analysis showed that women’s autonomy affected significantly on unintended pregnancy after controlling other variables. However, it implied a negative correlation in which autonomous women were 1.3 more likely to experience unintended pregnancy than their counterparts. Both parity and birth interval showed the biggest influences on unintended pregnancy; the odds ratios were 2.7 and 3.1 respectively. Women who married at age 21 years and above, lived in rural areas and decided the number of children to have with husbands tended to have a lower risk facing an unintended pregnancy. Improving IEC and counseling about family planning and reproductive health is expected to increase couples’ knowledge. Therefore, the decisions on the number of children and contraceptive use can be made jointly and unintended pregnancy will be prevented.
THE CORRELATION BETWEEN HEREDITY AND MASS MEDIA EXPOSURE FACTORS ON THE EARLY MENARCHE INCIDENT ON ADOLESCENT GIRLS
Authors: Tamo Agrini Yesiska , Anis Wahyul , Presetyo Budi
Published: November 2022

Menarche is the first menstruation that occurs in young women. The normal age is 12-14 years, but now there’s a tendency to decrease to younger age. The purpose of this study was to analyze the correlation of heredity and mass media exposure factors with the incidence of early menarche in adolescent girls at SMPN 56 Surabaya. The study used an observational analytic design with a cross-sectional approach. The sample of this research was adolescent girls of 7th-8th grade of SMPN 56 Surabaya and mothers, taken using simple random sampling method. The instrument was a questionnaire distributed online. The research data analyzed using the Chi-square test. The results showed that 39.13% adolescent girls who experienced early menarche had mothers who had a history of early menarche. The mass media exposure with a light level was 15.21% experienced premature menarche, while 84.78% experienced early menarche. The results of the Chi-square correlation test analysis between heredity and the incidence of early menarche in young girls stated that there was no relationship between the two variables with p = 0.068. The results of Chi-square analysis between the mass media exposure factors and the incidence of early menarche in young women obtained p value = 0.030, which can be concluded that there is a relationship between the two variables. The study concluded that there is a relationship between exposure to mass media and the incidence of menarche in young women so that supervision of adolescent girls is needed in accessing information in the mass media.
DIFFERENCE OF DIVORCE DETERMINATION IN INDONESIA: A STUDY SYSTEMATIC LITERATURE REVIEW
Authors: Latifah Luluk , Ritonga Iskandar
Published: November 2022

The divorce rate is getting more and more concerning. The number of divorce rate shows a significant increase both nationally and regionally in Indonesia. During 2019, there were 480,618 divorce cases. This divorce rate increased by 18% compared to the previous year which amounted to 408,202 cases. This paper aims to determine the determinants of divorce in Indonesia, using a Systematic Literature Review of 20 journals published by indexed publishers. The results based on the mapping state that the differentiation of the determinants of divorce in Indonesia very much depends on each region. However, all of them can be mapped into 16 factors that cause divorce, namely: economic factors, responsibility, continuous quarrels, harmony, infidelity, domestic violence, jealousy, leaving a partner, forced marriage, apostasy/leaving Islam, drunkenness and gambling, obstructed communication, interference/third party intervention, incompatibility, unhealthy polygamy, and moral crisis. The conclusion of this study is that the strongest determinant of divorce in Indonesia in each region is the economic factor. Economic factors are the strongest factor causing divorce, because the cause of divorce in almost all areas with the highest frequency and the highest percentage is also compared to other causes of divorce.
The genus Canthium (Rubiaceae, Vanguerieae) in Thailand, with a note on the typification of the genus
Authors:   Naturalis Biodiversity Center, section Botany, P.O. Box 9517, 2300 RA Leiden, The Netherlands, De Wilde Willem J.J.O. , Duyfjes Brigitta E.E. ,   Naturalis Biodiversity Center, section Botany, P.O. Box 9517, 2300 RA Leiden, The Netherlands
Published: November 2022

Canthium s.s. comprises sixteen species in Thailand. They are described and annotated, and placed in a key to the species. The type species of the genus is Canthium parviflorum, from India, but this name is not antedated by C. coromandelicum, which is a different species. Canthium parviflorum is lectotypified. For Thailand three new species, Canthium flavovirens, C. grandiflorum, and C. rotundum are described, and thirteen lectotypes are designated.
TELAAH KONSEP OTAK DALAM AL-QUR’AN
Authors: Tamin Andi Khuzaimah
Published: November 2022

The dichotomy between religion and science does not only occur in the west, but also occurs in Islamic civilization after the golden age of Islam during the caliphate of the Abbasid dynasty. To get the relationship between religion and science, the researchers focused this research on how the Qur'an views the brain which is the container for human thinking. The resulting relationship between the Qur'an and the brain later is a natural theological integration relationship promoted by Ian Barbour. That way, the brain as a microcosm of nature becomes a supporter of experimentation (aqli) from the scientific verses of the Qur'an which are the source of naqli for Muslims. Therefore, it will be revealed how the concept of the brain in the Qur'an, whether the brain itself is mentioned in the Qur'an or is the brain only mentioned for its functions.
KONSEP WAHYU DALAM AL-QUR’AN PERSPEKTIF SEKTE AHMADIYAH
Authors: Mujahidin Muhammad Saekul
Published: November 2022

The Prophet (saw) said: “Difference among my Ummah is a mercy.” The emergence of new sects is a manifestation of the current current of human thought. This thought movement always affects the human condition, both positive and negative influences. The emergence of the Ahmadiyah sect, including the reformers of the Islamic world. Mirza Ghulam Ahmad is al-Mahdi and al-Masih. This study uses a library research approach. Revelation in the Ahmadiyah perspective has been confirmed in suras al-Jumu’ah/62:3 and as-Shaff/61:6, that both are the same and agree that the verse refers to the second coming of the Prophet Muhammad in the form of Mirza Ghulam Ahmad. Then the revelation referred to by other Ahmadiyah schools is not like the revelation in the Qur’an but the revelation of tajdid (renewal revelation) or muhaddas revelation (revelation received directly through direct dialogue with God).
PERKEMBANGAN TEMA JIHAD DALAM AL-QUR’AN BERDASARKAN KRONOLOGI MEHDĪ BAZARGĀN
Authors: Raa Muhamad
Published: November 2022

The misunderstanding about the doctrine of jihad, especially that echoed by jihadist-extremist groups, some start from a rigid reading of the text of the Qur'an. It is obvious that there is a need for a fresh new method of reading of the verses under the theme of jihad, namely tafsir mawḍūʿī-nuzūli or thematic-chronological interpretation. Using the Qur'anic chronology introduced by Mehdī Bazargān and the periodization he worked on on the same book, followed by linguistic-lexical approach, it can be found the development of jihad verses from (1) nonviolent jihad verses, to (2) jus ad bellum, and (3) juice in bello. Also in Bazargān's chronology it can also be seen that surah Al-Tawbah [9] :5, which was known as the verses of the sword, does not abrogated previous jihad-themed verses. This is because the message of jihad is closed with a prohibition for believers to act antagonistic to those who have been hostile to them and command them to cooperate with each other in goodness and piety.
Явная схема для решения нелинейного уравнения теплопроводности
Authors: Четверушкин Борис Николаевич , Chetverushkin Boris Nikolaevich , Ольховская Ольга Гургеновна , Olkhovskaya Ol'ga Gurgenovna , Гасилов Владимир Анатольевич , Gasilov Vladimir Anatol'evich
Published: November 2022

Разработан алгоритм численного решения нелинейных задач теплопроводности, хорошо адаптированный к архитектуре высокопроизводительных вычислительных систем. Метод основан на гиперболической модели теплопроводности с малым параметром при второй производной по времени и явной разностной схеме. Новая схема обеспечивает разрешение нелинейности со вторым порядком по времени с приемлемым временным шагом. Предложен эвристический алгоритм выбора параметров трехслойной разностной схемы. Обсуждается приложение к моделированию динамики плазмы.
Difficulties associated with differential diagnosis between cystic fibrosis and primary ciliary dyskinesia
Authors:   Research Centre for Medical Genetics, Moscow, Russian Federation, Zhekaite E.K. ,   Research and Clinical Institute of Childhood, Ministry of Health of Moscow Region, Moscow, Russian Federation, Voronkova A.Yu. ,   Research Centre for Medical Genetics, Moscow, Russian Federation,   Research and Clinical Institute of Childhood, Ministry of Health of Moscow Region, Moscow, Russian Federation, Adyan T.A. ,   Research Centre for Medical Genetics, Moscow, Russian Federation,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: November 2022

Differential diagnosis between some orphan diseases might be challenging for doctors. Cystic fibrosis and primary ciliary dyskinesia share the main pathogenetic feature, which is the accumulation of viscous inflammatory secretion in the lumen of the respiratory tract and impaired mechanisms of its escalation. Clinical manifestations of both diseases are similar. Objective. To demonstrate the difficulties associated with differential diagnosis between cystic fibrosis and primary ciliary dyskinesia on the example of a clinical case. We describe a patient who was initially diagnosed with cystic fibrosis in the Research and Clinical Institute of Childhood, but then was diagnosed with primary ciliary dyskinesia in the Department of Pulmonology, Y.E Veltischev Research and Clinical Institute for Pediatrics, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia. This case demonstrates the need for a more careful and thorough examination of children with chronic bronchopulmonary diseases, since some of them may share most of their clinical manifestations, for example cystic fibrosis and primary ciliary dyskinesia. Key words: cystic fibrosis, ciliary dyskinesia, differential diagnosis, light microscopy, sweat test, next-generation sequencing
Clinical characteristics of the pathogenic variant L138ins of the CFTR gene in patients with cystic fibrosis
Authors:   Academician E.A.Wagner Perm State Medical University, Perm, Russian Federation, Shadrina V.V. , Krasovsky S.A. ,   Scientific Research Institute of Pulmonology of the Federal Medical and Biological Agency of Russia, Moscow, Russian Federation, Zhekaite E.K. ,   Research Centre for Medical Genetics, Moscow, Russian Federation, Kondratyeva E.I. ,   Research Centre for Medical Genetics, Moscow, Russian Federation, Furman E.G. ,   Academician E.A.Wagner Perm State Medical University, Perm, Russian Federation
Published: November 2022

In this study, we analyzed phenotypic manifestations and clinical course of cystic fibrosis (CF) in patients with the pathogenic variant L138ins of the CFTR gene. The L138ins variant is rarely detected in CF patients worldwide, but is quite common in different regions of the Russian Federation, particularly in the Middle Urals. Before the neonatal screening implementation, the majority of CF patients with the L138ins variant were diagnosed late because of the mild disease course and dubious results of sweat tests. Such patients usually have elevated levels of immunoreactive trypsinogen (IRT) in the neonatal period, which enables early diagnosis; however, false-negative results in CF patients have also been reported. There were cases of male infertility among CF patients with the L138ins variant, while women had their reproductive function preserved. There were also cases of asymptomatic pancreatic hyperenzymemia in children. Respiratory infections caused by Pseudomonas aeruginosa are not very common in this group of patients. However, adult patients have more severe respiratory manifestations (even with a fatal outcome) than children. Thus, despite the mild disease phenotype in patients with the L138ins variant, the residual function of the protein is not sufficient to ensure normal functioning of lungs. Key words: cystic fibrosis, pathogenic CFTR variants, L138ins
Effectiveness of neonatal screening for cystic fibrosis in the Russian Federation
Authors:   Research Centre for Medical Genetics, Moscow, Russian Federation, V.D.Sherman V.D.Sherman ,   Scientific Research Clinical Institute of Childhood Ministry of Health of the Moscow region, Moscow, Russian Federation, S.I.Kutsev S.I.Kutsev ,   Research Centre for Medical Genetics, Moscow, Russian Federation, V.L.Izhevskaya V.L.Izhevskaya ,   Research Centre for Medical Genetics, Moscow, Russian Federation, E.I.Kondratyeva E.I.Kondratyeva ,   Research Centre for Medical Genetics, Moscow, Russian Federation,   Scientific Research Clinical Institute of Childhood Ministry of Health of the Moscow region, Moscow, Russian Federation
Published: November 2022

Mass neonatal screening (NS) for cystic fibrosis (CF) has been performed in the Russian Federation since 2006–2007. It includes measurement of serum immunoreactive trypsinogen (IRT) in the first week of life and repeated testing on day 21–28 in case of positive first test. The sweat test is used to confirm the diagnosis. Objective. To evaluate the effectiveness of neonatal screening for cystic fibrosis in the Russian Federation. Materials and methods. We collected information on key parameters of NS for cystic fibrosis for 2019 from regional specialists in medical genetics. Results. We collected information form 50 regions of the Russian Federation, where a total of 1,009,832 newborns had been examined. The number of newborns with elevated IRT was 9,138 (0.9%); 1388 (0.1%) newborns tested positive at reexamination. CF was diagnosed in 104 newborns. Two pathogenic variants in the CFTR gene were detected in 78 infants with CF (75%); one pathogenic variant, in 20 infants (19%); no pathogenic variants, in 3 infants (2.9%). The NS protocol was not completed in 395 patients (4.3%). False negative screening results were observed in 8 newborns (7.1%), including two with meconium ileus. The sensitivity of screening was approximately 93%. One hundred and four infants tested positive at reexamination had no final diagnosis. The mean age at examination by a CF specialist was 41 (±21) days. More than two-thirds of newborns (73%) were diagnosed in outpatient departments, while the remaining patients (27%) were diagnosed in hospitals. We obtained mean cut-off values for IRT. Conclusion. Dynamic analysis of NS performance is a promising approach for its optimization. Key words: cystic fibrosis, neonatal screening, immunoreactive trypsinogen, sweat test, false positive result
Pancreatitis in children with cystic fibrosis and preserved pancreatic exocrine function
Authors:   Research Centre for Medical Genetics, Moscow, Russian Federation, Voronkova A.Yu. ,   Scientific Research Clinical Institute of Childhood Ministry of Health of the Moscow region, Moscow, Russian Federation, Kondratyeva E.I. ,   Research Centre for Medical Genetics, Moscow, Russian Federation,   Scientific Research Clinical Institute of Childhood Ministry of Health of the Moscow region, Moscow, Russian Federation, Nikolaeva E.D. ,   Research Centre for Medical Genetics, Moscow, Russian Federation,   Scientific Research Clinical Institute of Childhood Ministry of Health of the Moscow region, Moscow, Russian Federation, Pasnova E.V. ,   Scientific Research Clinical Institute of Childhood Ministry of Health of the Moscow region, Moscow, Russian Federation, Fatkhullina I.R. ,   Research Centre for Medical Genetics, Moscow, Russian Federation,   Scientific Research Clinical Institute of Childhood Ministry of Health of the Moscow region, Moscow, Russian Federation, Odinaeva N.D. ,   Scientific Research Clinical Institute of Childhood Ministry of Health of the Moscow region, Moscow, Russian Federation
Published: November 2022

The pancreas is one of the main organs affected by the dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Pancreatitis can be a symptom of cystic fibrosis (CF) or a CFTR-related disorder. Genetic variants of the CFTR gene causing CF or having varying clinical significance are observed in 32–48% of patients. Approximately 20% of patients with mild genotypes are expected to develop pancreatitis. We report three cases of pancreatitis in children with CF and preserved pancreatic function. We focus on the challenges associated with the assessment of pancreatic insufficiency grade, suffering of children with recurrent acute and chronic pancreatitis, difficulties associated with the diagnosis and interpretation of laboratory parameters, problems of prognosis of pancreatitis development and progression in patients with pathogenic variants of the CFTR gene. Patients with mild pathogenic variants of the CFTR gene can have their pancreatic elastase-1 level reduced over time, which necessitates its annual monitoring. Patients with mild pathogenic variants should be routinely tested for pancreatic amylase, lipase, and diastase; and undergo examination using visualization methods. All CF patients require complete genotype verification to identify those with a mild genotype. Patients with recurrent pancreatitis should be checked for heterozygous pathogenic variants of the CFTR gene or CF verification. Key words: CFTR gene, cystic fibrosis, mild genotype, pancreas, pancreatitis, pancreatic elastase
Efficacy of lumacaftor/ivacaftor in a child with severe cystic fibrosis
Authors:   Russian Pediatric Clinical Hospital, N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Goryainova A.V. , Semykin S.Yu. ,   Russian Pediatric Clinical Hospital, N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Mikhalaki P.I. ,   Russian Pediatric Clinical Hospital, N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: November 2022

We report a case of successful treatment of severe mixed cystic fibrosis in a 11-year-old child using lumacaftor 100 mg/ivacaftor 125mg, a CFTR modulator. This case shows that lumacaftor/ivacaftor is effective in patients who already developed chronic respiratory failure and have low basal FEV1. Key words: CFTR modulators, lumacaftor/ivacaftor, cystic fibrosis
Tailored approach to the treatment of pulmonary mycobacteriosis in patients with cystic fibrosis
Authors:   Central Research Institute of Tuberculosis, Moscow, Russian Federation, Panova L.V. , Ovsyankina E.S. ,   Central Research Institute of Tuberculosis, Moscow, Russian Federation, Kondratyeva E.I. ,   Research Center for Medical Genetics, Moscow, Russian Federation, Nikolaeva E.D. ,   Research Center for Medical Genetics, Moscow, Russian Federation
Published: November 2022

Diagnosis, treatment, and follow-up of children with cystic fibrosis and pulmonary mycobacteriosis pose a challenge due to lack of scientifically justified clinical recommendations on patient management. The article provides two clinical observations, illustrating a personalized approach to administration of antibacterial therapy to children with cystic fibrosis and bronchopulmonary comorbidity caused by nontuberculous mycobacteria. Clinical, microbiological, and radiological study results were interpreted to define treatment tactics. Key words: children, cystic fibrosis, pulmonary mycobacteriosis, nontuberculous mycobacteria
Current understanding of vitamin D and genetic regulation of inflammation on the example of bronchial asthma
Authors:   Research Clinical Institute of Childhood of the Ministry of Health of the Moscow region, Moscow, Russian Federation, Loshkova E.V. ,   Siberian State Medical University, Tomsk, Russian Federation, Kondratyeva E.I. ,   Research Clinical Institute of Childhood of the Ministry of Health of the Moscow region, Moscow, Russian Federation,   Research Centre for Medical Genetics, Moscow, Russian Federation, Malinovskaya M.G. ,   Research Clinical Institute of Childhood of the Ministry of Health of the Moscow region, Moscow, Russian Federation, Yankina G.N. ,   Siberian State Medical University, Tomsk, Russian Federation
Published: November 2022

Bronchial asthma (BA) is a heterogeneous chronic inflammatory disease characterized by a variety of symptoms in the form of wheezing, breathlessness, chest tightness and/or cough, as well as variable exhaled airflow limitation, with both the combination of symptoms and airflow limitation changing with time and intensity. Asthma is associated with both airway hyperresponsiveness to direct or indirect stimuli and chronic airway inflammation. Therapy for BA in accordance with national guidelines and clinical recommendations successfully controls asthma symptoms in most patients. However, there are several problems. Firstly, up to 5% of patients with asthma have a refractory course, respond inadequately to traditional therapeutic approaches and, therefore, are at greater risk of life-threatening asthma exacerbations. Secondly, a significant number of patients, even with mild to moderate asthma, have poor symptom control and may experience severe exacerbations. Low vitamin D levels are associated with decreased lung function, increased asthma exacerbations, and drug use, although it is not clear whether there is a causal relationship between these observations, and whether asthma patients may benefit from vitamin D supplementation. The authors present in this literature review the mechanisms by which vitamin D can reduce the severity of inflammation in BA. The research is focused on studying the mechanisms of chronic respiratory inflammation and their exogenous and genetic regulation involving genetic variants of the VDR gene and vitamin D metabolites. Keywords: children, vitamin D, 25(OH)D deficiency, asthma, inflammation, VDR
Feminicidio en Ciudad Juárez. Representaciones en discursos audiovisuales
Authors: Buenrostro Pérez Carolina
Published: November 2022

El feminicidio en México es un grave problema que continúa creciendo a lo largo y ancho del país sin que existan acciones efectivas por parte del Estado para su resolución. Por el contrario, es un tema tabú para el Gobierno mexicano, cuyo discurso continúa minimizando el problema e invisibilizando a las víctimas. Sin duda, desde hace ya casi tres décadas, Ciudad Juárez se convirtió en el cronotopo emblemático del feminicidio en México y el mundo por el alto número de asesinatos de mujeres que se registraron en esta ciudad.
Nazi Almanyası’na Giden Süreci Yaratmak: Paris Barış Konferansı, Versailles Antlaşması ve Weimar Almanyası
Authors: ÖZEL ÖZCAN Merve Suna , TUTUŞ Lütfi
Published: November 2022

Amaç: Bu makalenin amacı, Weimar Almanyası’nda Nazi iktidarının inşasında Paris Barış Konferansı ve Versailles Anlaşması’nın rolünün ve ilişkisinin incelenmesidir.
Tasarım/Yöntem: Çalışma, küresel çapta yarattığı etki kapsamında I. Dünya Savaşı sonrasında Alman topraklarında yaşanan gelişmeleri incelemektedir. Bu etkileri görebilmek adına çalışma tek vakalı örnek olay incelenmesidir. Buradaki temel metot tarihsel örnek odaklı olarak örnek olay odaklıdır. Bu sayede çalışmada uluslararası alanda yaşanan süreci anlama adına tanımlayıcı bir analiz sunulacaktır.
Bulgular: Paris Barış Konferansı’nda ABD, Fransa ve İngiltere Almanya’yı Avrupa Kıtası’nın “ötekisi” konumunda ele almışlardır. Öteki’nin hayat sahası (lebensraum) Versailles Antlaşması ile belirlenirken, kurulan kukla rejimle antlaşma şartları uygulanmak istenmiştir. Buna rağmen Kıta’da yeni bir denge uğruna atılan adımlar faşist yönetimin iktidarını hazırlamıştır.
Sınırlılıklar: Almanya’da Nazi iktidarına giden süreç incelenirken ABD, İngiltere ve Fransa’nın yaklaşımları ele alınarak aktör bağlamında bir sınırlamaya gidilmiştir. Paris Barış Konferansı’nda Almanya’yı ilgilendiren konular ve Versailles Antlaşması’nın belli başlı şartları üzerinden tartışmanın yürütülmesi, makalenin amacının ortaya çıkartılması adına bir diğer sınırlılık oluşturmuştur.
Özgünlük/Değer: Daha önceki Avrupa uyumlarının aksine bu defa Avrupa Kıtası’nın dışından bir aktör yani ABD idealist enstrümanları ile realist geleneğin Avrupalı güçlerinin karşısındadır. Realist ve idealist gelenek arasındaki sistemin algılanış farklılıkları fikirsel çatışmaya dönüşmüştür. Bu çatışma Paris Barış Konferansı’nda ele alınan konular ve Versailles Antlaşması’nın maddeleri üzerinden kendini açık ederken, aktörler istemeye istemeye de olsa Avrupa’da ulus-devletlerin ilk faşist yönetimini yaratmışlardır. Çalışmanın özgünlüğü de uluslararası ilişkiler disiplinin ilk yıllarında karşı karşıya gelen bu iki anlayış arasındaki çatışmanın Nazi Almanya’sını nasıl inşa ettiğinin incelenmesidir.
Buku Ajar Bahasa Arab Kelas 4 Madrasah Ibtidaiyah: Analisis Standar 5C ACTFL
Authors: Cahya Kiki , Ainin Moh. , Sanusi Anwar
Published: November 2022

5C’s of the American Council on Teaching of Foreign Languages ​​(ACTFL) is a standard in teaching foreign languages ​​in the United States, which emphasizes five important and interrelated things in teaching foreign languages; communication, culture, connections, comparisons, and communities. The 5C’s of ACTFL are used as a guide in creating a curriculum that can enable students to develop various skills, gain insights from other cultures, connect language skills acquired with other scientific fields, develop insights by comparison, and participate in a multilingual society. This study aim to answer the question of the results of the ACTFL 5C’s standard analysis in the Arabic textbooks for class 4 in Madrasah Ibtidaiyah published by the Ministry of Religion of the Republic of Indonesia. This type of research is library research conducted with research objects or library data collection. The analysis found that the Arabic textbook complies with the ACTFL 5C’s standard. The Arabic textbook can optimize learning Arabic for elementary school; Madrasah Ibtidaiyah class 4. In detail, the percentage of the ACTFL 5C’s standard is 31% communication, 25% cultures, 22% connections, 14% comparisons, and 8% communities.
FABRICATION OF PLASTIC SCINTILLATOR USING POLYSTYRENE MATRIX BASED
Authors: Nuri Hafni Lissa , Pancoko Marliyadi , Jami Abdul , Subhiyah Hana , Ardiyati Tanti , Sari Dian Maya , Desviana Adinda Tisha
Published: November 2022

Experiments on making a plastic scintillator with polystyrene as a base material mixed with fluorescent compounds (primary and secondary dopants) have been performed. Primary dopants (PTP) used to produce emission at wavelengths of visible light and secondary dopants (POPOP) to shift the visible wavelengths to wavelengths that could be detected by Photomultiplier Tube (PMT) ) were carried out. Experiments were performed on the melting points condition of these materials, which had previously been subjected to a thermo-mechanical analysis using a Thermogravimetric Analysis-Differential Scanning Calorimetry (TGA-DSC) machine, where the melting point was in the range of 200-240°C. Furthermore, the fabrication was carried out using the extrusion technique, where polystyrene pellets mixed with PTP (1.5% by weight) and POPOP (0.05% by weight) were fed into an extrusion machine which has four hot areas to obtain a thin plate plastic scintillator. The plates were then analyzed with a UV-Vis Spectrophotometer to determine the absorption spectrum and Fluorescence Spectrophotometer to determine the emission spectrum. From the results of the analysis, it was found that the samples that went through scintillation pellets and without the addition of antioxidants had absorption spectrum data of 330 nm and emission spectrum of 421 nm. These values are in accordance with the characteristics of plastic scintillators on the market.
Coalition of Faith Leaders, Community Organizations, and Governmental Organizations to Implement a COVID-19 Campaign in a Latino Neighborhood, Baltimore, Maryland, 2020–2021
Authors: Bigelow Benjamin F. , Martínez Diego A. , Phillips Katherine , Parent Cassandra , Saxton Ronald E. , Yang Cui , Page Kathleen R.
Published: November 2022

The disproportionate impact of COVID-19 on low-income Latinos with limited access to health care services prompted the expansion of community-based COVID-19 services. From June 25, 2020, to May 20, 2021, we established a coalition of faith leaders, community organizations, and governmental organizations to implement a Spanish-language hotline and social media campaign that linked people to a COVID-19 testing site at a local church in a high-density Latino neighborhood in Baltimore, Maryland. This retrospective analysis compared the characteristics of Latinos accessing testing in community versus health care facility–based settings. (Am J Public Health. 2022;112(S9):S913–S917. https://doi.org/10.2105/AJPH.2022.307074 )
Forecasting Iranian Government Responses to Cyberattacks
Authors: Givens Austen , Sanders Nikki , Douglas Corye J.
Published: November 2022

Extant scholarship on Iranian cyber warfare emphasizes the ways in which Tehran’s cyber capabilities might be employed offensively to achieve its foreign policy objectives. Comparatively little attention, however, has been given to the ways in which Iran might leverage these same cyber assets in retaliatory strikes. This article argues that because of the unique combination of endogenous and exogenous variables affecting contemporary Iran, including diplomatic isolation and economic sanctions, as well as Iran’s historical track record of carrying out its foreign policy through proxies, Iranian cyber retaliation is likely to be executed through third parties, mostly symbolic in nature, and proportionate in scale.
Machine-Learning Model Improves Gas Lift Performance and Well Integrity
Authors: Carpenter Chris
Published: November 2022

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This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper SPE 205134, “Machine-Learning Application for Gas Lift Performance and Well Integrity,” by Mostafa Sa’eed Yakoot, SPE, Gulf of Suez Petroleum; Adel M.S. Ragab, SPE, Suez University; and Omar Mahmoud, SPE, Future University in Egypt. The paper has not been peer reviewed.

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The main objective of this work is to use machine-learning (ML) algorithms to develop a powerful model to predict well-integrity (WI) risk categories of gas-lifted wells. The model described in the complete paper can predict well-risk level and provide a unique method to convert associated failure risk of each element in the well envelope into tangible values.

ML Model

The model can be subdivided into four submodels as follows:

- The predictive model, which predicts the risk status of wells and classifies their integrity level into five categories rather than three broad-range categories, as in qualitative risk classification. The five categories are

-- Category 1, which is too risky

-- Category 2, which is still too risky but less so than Category 1

-- Category 3, which is medium risk but can be elevated if additional barrier failures occur

-- Category 4, which is low risk but features some impaired barriers

-- Category 5, which is the lowest in risk

- The failure model, which identifies whether the well is considered to be in failure mode. In addition, the model can identify wells that require prompt mitigation.

- The suboptimal model, which identifies wells operating out of the integrity envelope.

- The diagnosis model, which locates the root of cause of WI impairment and introduces an action plan.

This classification was performed using ML algorithms such as logistic regression, decision trees, random forest, Gaussian, K-nearest neighbor, and support-vector machine classifiers.
Gill proteome networks explain energy homeostasis during salinity stress in Oreochromis mossambicus
Authors: Root Larken , Kültz Dietmar
Published: November 2022

Acclimations of Oreochromis mossambicus to elevated salinity were conducted with multiple rates of salinity increase and durations of exposure to determine the rate-independent maximum salinity limit and the incipient lethal salinity. Quantitative proteomics of over 3000 gill proteins simultaneously was performed to analyze molecular phenotypes associated with treatments representative of key zones in the salinity-level x duration matrix. For this purpose, a species- and tissue-specific data-independent acquisition (DIA) assay library of MSMS spectra was created. From these DIA data, protein networks representing complex molecular phenotypes associated with salinity acclimation were generated. Organismal performance indicators of salinity tolerance were then correlated with salinity-regulated protein networks. O. mossambicus was determined to have a wide “zone of resistance” from approximately 75g/kg salinity to 120g/kg, which fish survive for a limited period with eventual loss of function. Crossing the critical threshold salinity into the zone of resistance corresponds with blood osmolality increasing beyond 400 mOsm, significantly reduced body condition factor, and cessation of feeding. Gill protein networks impacted at extreme salinity levels both above and below the critical salinity threshold include increased energy metabolism, especially upregulation of electron transport chain proteins, and regulation of specific osmoregulatory proteins. Cytoskeletal, cell adhesion, and extracellular matrix proteins are enriched in regulation network patterns that are sensitive to the critical salinity threshold. Network analysis of these patterns provides deep insight into specific mechanisms of energy homeostasis during salinity stress.
Does exposure to green or blue space impact dietary intake and food choices among adults? A Systematic Literature Review.
Authors: Gilbourne Claire A. , Scarry Alan , Tierney Audrey C. , Connor Eibhlís M. O’
Published: November 2022

The health benefits of exposure to greenspace are well researched; however, causal pathways for improved health outcomes are complex, and evidence is minimal on potential moderating factors. This review aimed to assess the strength of the evidence and potential impact of exposure to green and blue spaces on dietary outcomes in adults. The inclusion criteria for the review were based on the PICO criteria. Five databases were searched: CINAHL, GreenFILE, AMED, Medline, and PubMed, accessed on 14th June 2021. The Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Analytical Cross-Sectional Studies was used for quality assessment in all studies. Due to heterogeneity, narrative synthesis was conducted to evaluate the relationships between the included studies. Four observational studies which reported diet-related outcomes were included in the review, and participants within the studies ranged from 554 to > 350,000 participants. Other health outcomes, including physical activity and obesity, have also been reported. Socioeconomic status (SES) was identified as a significant determinant of dietary intake and food choice. Two studies found that dietary patterns were not correlated with exposure to greenspace. Due to the small number of articles retrieved and the paucity of evidence, the findings need to be interpreted with caution. Further research is required to elucidate the complex mechanisms involved. Research is also needed to determine which greenspace attributes impact dietary intake and food choices among adults. When developing public health interventions, the significant health benefits associated with different socioeconomic groups should be considered.
Exploratory cross-sectional study to evaluate the metalloproteinases role as ‘immunoscore’ for HPV-induced cervical lesions
Authors: Lopes Gisele Silva , Rocha Natália Pereira , Russomano Fabio Bastos , Avvad-Portari Elyzabeth , Andrade Cecília Vianna , Furtado Yara Lúcia , Guerra-Neto Nereu Gilberto Moraes , Roma Eric Henrique , Bonecini-Almeida Maria da Gloria , Fernandes Ana Teresa Gomes
Published: November 2022

Cervical cancer (CC) is the fourth most common type of cancer among women and is responsible for about 8% of female cancer deaths worldwide. Understanding how the tumor microenvironment behaves is essential to realize the carcinogenic process, and thus infer possible prognostic biomarkers in the CC development. One of the prognostic factors that has aroused interest in recent years is the increased expression of metalloproteinases (MMPs) in tumor tissues, which is associated with tumor growth and metastasis, and recurrence of degradation of extracellular matrix (ECM) components in tissues of different tumors. Thus, our objective is to evaluate the in situ distribution of MMPs+ cells (MMP-2, -7, -9), as well as TIMP-2+, EphA2+ and EfrinA1+ cells in intraepithelial (IE) and marginal stroma (MS) areas using the technique of immunohistochemistry and immunoscore analysis in low- and high-grade squamous intraepithelial lesions (LSIL and HSIL, respectively) and CC. We observed in MS, a high distribution of MMPs+ (-2, -7 and − 9), TIMP2+ and EPHA2+ cells in the HSIL and CC group compared to the control. Regarding IE, we observed this same pattern, except in EPHA2 where there was a decrease in the positive cells distribution in CC compared to control and LSIL. Regarding the “immunoscore”, from 15 possible profiles, we found statistical differences in only 9 (MMP-2+/MMP-9+, MMP-2+/EphA2+, MMP-7+/MMP-9+, MMP- 7+/TIMP-2+, MMP-7+/EphA2+, MMP-9+/EphA2+, TIMP-2+/EphA2+, TIMP-2+/EphrA1+ and EphA2+/EphrA1+) when the groups were compared. However, only the MMP-7+/MMP-9+ profile can be used as a prognostic factor for the development of CC and the MMP-7+/EphA2+, MMP-9+/EphA2+ and TIMP-2+/EphA2+ profiles may be related to the development of precancerous lesions. A more comprehensive review of longitudinal studies should be performed to link these “immunoscores” to CC progression and validate their value as a prognostic method.
Preparation, Characterization and Antiviral Evaluation of Curcumin-PLGA and Curcumin-metal oxide nanocomposite against SARS-CoV-2
Authors: Elbadawy Zahraa Ahmed , Mostafa Ahmed , Ragab Ghada M. , Shama Nora. M. Abo , El-Dek Samaa , El-Shahawy Ahmed A. G.
Published: November 2022

Our usual control strategies for viral infections are still not as effective as demand, and the need for different ways of treatment is still of high priority. Viruses undergo genetic mutations that prevent specific drugs from affecting new strains. This research is concerned with the usage of nanotechnology in the preparation of natural drug classes that can be more effective when dealing with emerging pathogens. Curcumin is a natural extract of Curcuma longa that is known for its wide therapeutically effect due to its binding with different enzymes and proteins in the body. The curcumin can bind to viral proteins and block their activity; however it has poor water solubility and bioavailability. Likely, curcumin nanoparticles have much better solubility and bioavailability. This can improve our traditional treatment or prophylactic methods for viral infections and pandemics. This study is concerned with curcumin nanoparticle formulations and their anti-viral activity. Curcumin has been loaded onto PLGA to form Cur-PLGA nanoparticles. In parallel, curcumin was added to ZnO to form a Cur-ZnO composite. The compositions of PLGA and ZnO preparations with different concentrations of curcumin were confirmed with a panel of physiochemical assays. In vitro, the Cur-ZnO composite demonstrated significantly higher anti-SARS-CoV-2 activity than Cur-PLGA with significantly higher host cell safety. The study emphasizes the preference of curcumin composite nanoparticles over curcumin loaded nanoparticles. This study highlights the robust antiviral activity of different curcumin-based ZnO nanoparticles. This preliminary study demands further preclinical and clinical studies to confirm the obtained results in vivo.
Oxidation of alcohols to carbonyl compounds over graphene oxide functionalized with copper-thiazole as a catalyst
Authors: Dehbanipour Zahra , Zarnegaryan Ali
Published: November 2022

‎‒‎The catalytic behaviour of [Cu(II)Br2-BTP@MNPs] and [Cu(II)Br2-BTP@GO] catalysts have been studied for the oxidation of alcohol derivatives. The comparative study indicates that the [Cu(II)Br2-BTP@GO] possesses better catalytic activity over the [Cu(II)Br2-BTP@MNPs] catalyst. In this reaction, we used a green solvent such as water in presence oftert-Butyl hydroperoxide (tert-BuOOH) as oxidant. The prepared catalyst was characterized by AAS, XRD, FE-SEM, TEM, TGA, elemental analysis and FT-IR spectroscopic techniques, also FT-IR spectroscopy and X-ray diffraction (XRD) were used for characterization of recovered catalyst. The catalyst is stable and can be recovered even after five consecutive cycles of reaction with only a slight loss in its catalytic activity.
Cytotoxic, anti-proliferative, and apoptotic evaluation of Ramalina sinensis (Lichenized fungus, Ramalinaceae) on oral squamous cell carcinoma cell line; in-vitro study
Authors: Karimi Hanieh , Koopaie Maryam , Sohrabi Mohammad , Norouzi Hooman
Published: November 2022

Background: In response to the poor prognosis of oral squamous cell carcinoma (OSCC), the most frequent cancer in the oral cavity, efforts have been made to create more effective treatment methods based on natural products. Lichens are a source of active pharmacologic compounds, which have lately been discovered to be helpful in cancer treatment. Current research seeks to evaluate the impact of Ramalina sinensis (R. sinensis) lichen on the cell viability and apoptosis of OSCC cell lines, considering lichens’ anti-inflammatory and anticancer capabilities.
Methods: R. sinensis was selected for investigation of its effects on human oral squamous cell carcinoma cell line (KB cell line, NCBI Code: C152) and acetone and effect of methanol extract of R. sinensison OSCC cell line was investigated. The chemical composition and metabolic profiling of R. sinensis were investigated. Viability was assessed by MTT assay analysis, and apoptotic cells were measured using flow cytometry analysis. Scratch assay was used to assess cell migration.
Results: The chemical composition of R. sinensis was investigated using LC-ESI-MS/MS, and 33 unique compounds in acetone and methanol extract of R. sinensis were detected. The proliferation of KB cells was gradually but significantly inhibited by 6.25, 12.5, 25, 50, 100, and 200 μg/mL in a time-dependent manner. There was a statistically significant difference between acetone and methanol extract in the inhibition of cell proliferation. Flow cytometry results indicate an increase in apoptosis of OSCC cells by acetone extract. R. sinensis significantly inhibited the migration and invasion of OSCC cells in a concentration-dependent manner.
Conclusion: The results of the present study showed the positive effects of R. sinensis extract on the apoptosis of OSCC cells and the anticancer effects of R. sinensisextracts.