bluuebunny/crossref_metadata_2025 huggingface dataset:
Prediction by genetic MATS of 4CMenB vaccine strain coverage of invasive meningococcal serogroup B isolates circulating in Taiwan between 2003 and 2020
Authors: Muzzi Alessandro , Lu Min-Chi , Mori Elena , Biolchi Alessia , Fu Tiffany , Serino Laura
Published: May 2024

Neisseria meningitidis
serogroup B (NmB) strains have diverse antigens, necessitating methods for predicting meningococcal serogroup B (MenB) vaccine strain coverage. The genetic Meningococcal Antigen Typing System (gMATS), a correlate of MATS estimates, predicts strain coverage by the 4-component MenB (4CMenB) vaccine in cultivable and non-cultivable NmB isolates. In Taiwan, 134 invasive, disease-causing NmB isolates were collected in 2003–2020 (23.1%, 4.5%, 5.2%, 29.8%, and 37.3% from individuals aged ≤11 months, 12–23 months, 2–4 years, 5–29 years, and ≥30 years, respectively). NmB isolates were characterized by whole-genome sequencing and vaccine antigen genotyping, and 4CMenB strain coverage was predicted using gMATS. Analysis of phylogenetic relationships with 502 global NmB genomes showed that most isolates belonged to three global hyperinvasive clonal complexes: ST-4821 (27.6%), ST-32 (23.9%), and ST-41/44 (14.9%). Predicted strain coverage by gMATS was 62.7%, with 27.6% isolates covered, 2.2% not covered, and 66.4% unpredictable by gMATS. Age group coverage point estimates ranged from 42.9% (2–4 years) to 66.1% (≤11 months). Antigen coverage estimates and percentages predicted as covered/not covered were highly variable, with higher estimates for isolates with one or more gMATS-positive antigens than for isolates positive for one 4CMenB antigen. In conclusion, this first study on NmB strain coverage by 4CMenB in Taiwan shows 62.7% coverage by gMATS, with predictable coverage for 29.8% of isolates. These could be underestimated since the gMATS calculation does not consider synergistic mechanisms associated with simultaneous antibody binding to multiple targets elicited by multicomponent vaccines or the contributions of minor outer membrane vesicle vaccine components.

IMPORTANCE

Meningococcal diseases, caused by the bacterium
Neisseria meningitidis
(meningococcus), include meningitis and septicemia. Although rare, invasive meningococcal disease is often severe and can be fatal. Nearly all cases are caused by six meningococcal serogroups (types), including meningococcal serogroup B. Vaccines are available against meningococcal serogroup B, but the antigens targeted by these vaccines have highly variable genetic features and expression levels, so the effectiveness of vaccination may vary depending on the strains circulating in particular countries. It is therefore important to test meningococcal serogroup B strains isolated from specific populations to estimate the percentage of bacterial strains that a vaccine can protect against (vaccine strain coverage). Meningococcal isolates were collected in Taiwan between 2003 and 2020, of which 134 were identified as serogroup B. We did further investigations on these isolates, including using a method (called gMATS) to predict vaccine strain coverage by the 4-component meningococcal serogroup B vaccine (4CMenB).
10: ADJUSTMENT THE BEST STRATEGIES TO NEW EVIDENCE-BASED TEACHING: NEED TO CHANGE AND PROSPECTIVE FOR FUTURE
Authors: Taghipour Nikta , mosalanejad leili , Javdani Farshid , abdollahifard Saeed
Published: May 2024

Background and aims:

Evidence-based teaching has the potential to promote processing in learners that leads to better transfer of skills and knowledge to the workplace and contributes to the emergence of adaptive expertise. Research shows that evidence-based teaching strategies are likely to have the largest impact on student results. In this article we have tried to adapt evidence-based teaching with SPICES model and explore some the appropriate strategies to teaching evidence-based curriculum. Also we addressed some the new method of teaching that is adjustable to these strategies in teaching and learning in evidence- based curricula.

Methods:

This study covers the period of 2007–2013. Researches were done initially by single keywords and using OR/AND, for combining words such as: evidence-based education, teaching methods, teaching strategies, Spices strategies for identify publications from SID, IRANMEDEX, MAGIRAN, OVID, PROQUET, CINAHL, Google scholar, web of sciences and PubMed databases. A total of 309 publications were found, from which, after excluding duplication and non-related papers, only 28 publications were considered relevant to the subject and were examined thoroughly.

Results:

The best strategies which are considerable in teaching evidences- based content include: Clear Lesson Goals, Show & Tell, questioning to check for understanding, summaries new learning in a graphical way, practice makes perfect, Provide Your Students with Feedback, Be Flexible About How Long It Takes to Learn, Get Students Working Together and se meta-cognition. These strategies are adjustable to SPICES pattern in designing curriculum in medical education in some part as student's center, community based education, problem based learning that can be present in new method of teaching and learning such as team based, problem based, case based learning and so on.

Conclusion:

It is the responsibility of the academic institutions and policy-makers in medical education to provide condition that promotes evidence-based strategies and adjust to teaching method. It decreases the gap between theory and practice and it also promotes the quality of teaching- learning process in evidence-based contents.
104: QUALITY OF SLEEP AND DAILY ACTIVITY OF THE ELDERLY IN ZANJAN
Authors: Salimi Sedigeh , Pakpour Vahid , Hosseiny Raziehsadat
Published: May 2024

Background and aims:

Poor quality of sleep and daily activity in elderly people are associated with many physical and psychological problems that increase disability and need to use health services. The aim of this study was to determine the relationship between daily activities and quality of sleep in the elderly people.

Methods:

This Study was a correlational-descriptive study on390 elderly people in Zanjan in 2013. The sampling was done using a cluster and multistage method. Data were collected via face-to-face interview, using Pittsburgh Sleep Quality Index (PSQI) and a questionnaire on “activities of daily living” (ADL) and “instrumental activities of daily living” (IADL). Data analysis was performed using descriptive statistic including number, percentage, mean, standard deviation, and inferential statistical tests including Spearman's rank correlation coefficient, independent t-test and one-way analysis of variance.

Results:

The mean score of ADL and IADL was 11.58±0.81 (score range 0–14) and 11.23±2.93 (score range 0–18), respectively. In addition, 85.7%of the subjects in the study had poor sleep quality and only 14.3% had good sleep quality. The results also indicated no significant relationship between the daily activities and quality of sleep in the elderly, while Instrumental activities had a weak positive and significant correlation with their sleep quality (P≥0.05).

Conclusion:

Although the elderly in this study have poor sleep quality, they are independent in performing ADL and IADL. Furthermore, there is a weak and direct correlation between sleep quality and instrumental activities of the old people. Improvement of activity in the elderly can improve their quality of sleep.
105: RELATIONSHIP BETWEEN ANTENATAL AND POSTPARTUM DEPRESSION WITH WEIGHT RETENTION 1 YEAR AFTER CHILDBIRTH
Authors: Pourmehr Hanieh Salehi , Farshbafkhalili Azizeh , Mohammadi Fatemeh , Malakouti Jamileh , Rafiee Somayyeh , Abdi Mozhgan , Jafarilar Nayyer
Published: May 2024

Background and aims:

Prevalence of Obesity among childbearing age women has increased markedly in recent decades, and it has become a major health problem with probably impact on mental health of obese women. For many women, returning to prepregnancy weight is a challenge. This study performed to examine the extent to which trimesters of pregnancy and early postpartum depression is associated with weight retention 1 year after childbirth.

Methods:

In a prospective cohort study of 307 women enrolled in Project with title “association between prepregnancy BMI and postpartum depression”, 62 women with class 2 and 3 of obesity and 245 with normal prepregnancy BMI, reported depressive symptoms on the Edinburgh Postnatal Depression Scale (EPDS) at 1st, 2nd and 3rd trimesters of pregnancy and 6-8 weeks postpartum. A score >13 indicated probable depression. Associations between antenatal and postpartum depression with risk of substantial weight retention (at least 5 kg) 1 year after childbirth were assessed.

Results:

One hundred and forty nine women (76.8%) with normal prepregnancy BMI were not depressed during or after pregnancy, while these amounts were 22 women (47.8%) in obese group. 32 (16.5%) in normal BMI and 7 women (15.2%) in obese group experienced antenatal depression only, 5 (2.6%) in normal group and 6 (13.0%) in obese group experienced postpartum depression only and 8 (4.1%) in normal group and 11 women (23.9%) in obese group experienced both antenatal and postpartum depression (p<0.001). At 1 year, participants retained a mean of 2.52 kg (range −10 to 17) in normal BMI group and 18.1% retained at least 5 kg and in obese group slightly decrease was shown: −0.02 kg (range −14 to 12) with 11.1% with retained weight at least 5 kg. Binary logistic regression analyses, after adjustment for weight-related covariates, maternal sociodemographics, and parity, antenatal and postpartum depression showed antenatal depression, either alone or in combination with postpartum depression, was not associated with substantial weight retention (odds ratio (OR): 1.02, 95% confidence interval (CI): 0.94, 1.10).

Conclusion:

The results showed that obese women are most prone to have postpartum depression. However there was no association between substantial weight retention in the first postpartum year in our study, more research with high sample size and all BMI groups are needed. Moreover identifying the other risk factors for weight retention after birth to prevent obesity and its sequels on women to better decision making in prenatal care guidelines contents are required.
12: AN EVIDENCE-BASED REVIEW REGARDING OFF-LABEL PRESCRIPTIONS OF POLIDOCANOL
Authors: Ebrahimi Seyyed Reza Sadat
Published: May 2024

Polidocanol is approved for its competence in treatment of varicose veins and spider veins; however, unfortunately, many of its off-label uses are still underappreciated. Lack of an appropriate comprehensive review for off-label uses of this medication troubles physicians about making evidence-based decisions on prescribing it for its various outstanding off-label uses. This article attempts to provide physicians with the latest information concerning successful and unsuccessful use of polidocanol as an alternative treatment for esophageal and gastric varices, tendinopathy and epicondylitis, vascular malformations, varicocele, hydrocele and spermatocele, aneurysmal bone cysts, Itching, management of gastrointestinal bleeding, simple renal cysts, reducing the incidence and severity of radio-induced dermatitis, and hemorrhoids. Polidocanol eligibility as an alternative prescription, in comparison to other standard medications in each condition, is also discussed meticulously afterwards in this paper.
124: THE EFFECT OF EDUCATIONAL PACKAGE ON FUNCTIONAL STATUS OF PRIMIPAROUS WOMEN IN POSTPARTUM PERIOD: A RANDOMIZED CONTROLLED CLINICAL TRIAL
Authors: Shafaie Fahimeh Sehati , Mirghafourvand Mojgan , Bagherinia Marzieh
Published: May 2024

Background and aims:

Postpartum period is an important transition for parents, infants and families physiologically, emotionally and socially. The aim of this study was to determine the effect of training packages on functional status in the postpartum period.

Method:

This randomized controlled clinical trial was conducted on 136 primiparous women who were referred to health centers in Tabriz, Iran, for their second postpartum care (10–15 days after delivery). Primiparous women aged 18–35 with singleton pregnancy and term birth (37–42 weeks) were randomly assigned to training (n=68) and control (n=68) groups. The education group was provided with a face to face training session, three phone sessions, and a booklet. The control group received the routine postpartum care in days 1–3, 10–15, and 42–60. Participants completed the functional status questionnaire before the intervention and eight weeks postpartum. ANCOVA with adjustments for baseline score was used for analysis.

Results:

No statistically significant difference was found between the two groups in terms of socio-demographic characteristics except for infant's gender (p>0.05). At 6 weeks after the intervention and by adjusting for baseline scores, mean scores of functional status (Adjusted mean difference: 0.9; CI 95%: 0.8 to 1.03, p<0.001) in educational group were significantly higher than the control.

Conclusion:

Results showed that training women have a positive effect in improving their functional status.
133: THE EFFECT OF ZINGIBER OFFICINALE (GINGER) ON HYPERTENSION; A SYSTEMATIC REVIEW OF RANDOMISED CONTROLLED TRIALS
Authors: Torabi Mitra , Naeemzadeh Farnaz , Ebrahimi Vida , Taleschian-Tabrizi Negar , Pashazadeh Fariba , Nazemie Hossein
Published: May 2024

Background and aims:

Zingiber Officinale, commonly known as ginger, has been widely used traditionally in the daily diet and a variety of medicinal purposes. There are some animal studies on the hypotensive mechanism of ginger. The aim of this systematic review was to extract the evidence from all human participant randomized and quasi-randomized controlled trials that have assessed the effects of ginger on the blood pressure (BP) of any population.

Methods:

Databases including Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, CINAHL, ISI Web of Science and also local databases including Sid, magiran, iranmedex were searched up to June, 2016 without language limitation. Relevant bibliographies were also searched. Titles and abstracts were assessed independently by two reviewers and full papers of relevant articles were obtained and assessed. Randomized and quasi-randomized controlled trials on humans were enrolled in the review. Data extraction and risk of bias assessment were done by two reviewers independently and in a case of discrepancy final decision was made by the third reviewer. Meta-analysis was not possible because of heterogeneity of data and incomplete reporting of findings, thus results were synthesized narratively.

Results:

Initial searches yielded 60 articles. After analyzing full-text papers, 2 Randomized Controlled Trials (RCTs) met the inclusion criteria. A double blind RCT (n=70) compared the effect of ginger with placebo on cardiovascular risk factors in diabetic patients. There was no significant (p>0.05) effect on systolic nor diastolic pressure (Mean arterial blood pressure (MABP) changes was 0.1±1.1). A randomized three armed safety trial (n=60) studied the effects of 50 and 100mg/kg ginger and placebo in healthy subjects. 100 mg/kg dose significantly (p<0.05) lowered systolic BP from 114.3±3.22 mm Hg to 105.5±3.13 and diastolic BP from 73.3±3.35 mm Hg to 70.5±3.39 mm Hg within two hours.

Conclusion:

According to animal studies ginger has the potential to offer a natural alternative dietary supplementation to conventional anti-hypertensive agents, but still there is not enough evidence supporting this claim and current limited evidence is controversial. More human trials studying the effect of ginger on hypertensive patients using different dosage of a standardized extract are needed.
135: THE EFFECTS OF OBESITY AND VITAMIN D IN BODY RESPONSE TO HEPATITIS B VACCINE
Authors: Moludi Jalal , Alizadeh Mohammad
Published: May 2024

Background and aims:

Hepatitis B vaccination is the most successful way to prevent the virus infection. Serum concentration of vitamin D has recently been proposed as a novel predictor of response to antiviral treatment in chronic hepatitis infection. The main target of this paper was to review the recent knowledge regarding the association between obesity and vitamin D level and immune response to Hepatitis B vaccines.

Methods:

This review was written by referring to research literature including 32 articles published from 200 to 2015 on PubMed, Google Scholar, and Scopus databases. Searches were undertake on the key phrases of Hepatitis B, Obesity(overweight), Hepatitis B vaccine, antibody titre,Vitamin D level and other similar keywords. References included a variety of research papers (descriptive and analytical) and intervention articles.

Results:

In healthy patients, adequate hepatitis B surface antibody (HBsAb) titer is the most important for prevent hepatitis B. Secondly, obesity cased vitamin D insufficiency and immune system dysfunction. In patients with overweight, vitamin D deficiency is associated with a poor antibody formation upon hepatitis B vaccination, therefore hepatitis B vaccine maybe require booster doses at obese population should be considered.

Conclusion:

this review revealed an association between vitamin D deficiency and poor body response to vaccination in obese patients. The reduced immune response of overweight patients to immunization can be harmful not only for the patient but also for the community. In conclusion, vitamin D levels measured previously starting the vaccination should be considered.
145: THE PREVALENCE OF FATTY LIVER IN OVERWEIGHT AND OBESE CHILDREN COMPARED TO NORMAL CHILDREN
Authors: Zare Mostafa , Zhiani Asgharzade A , Mostafavi S , Abbasi F , Karimi M , Sobhani Shahmirzadi M , Zarei H , Gharib MH
Published: May 2024

Background and aims:

Nonalcoholic fatty liver disease is the most common cause of liver disease worldwide and is defined as a disorder of excess fat accumulation in the liver. This study aimed to determine the prevalence of fatty liver among overweight and obese children compared to normal children.

Methods:

This case-control study was conducted on 90 children ages 5 to 13. Children's Body Mass Index (BMI) was determined and the three groups obese (95% >BMI), over weight (85–95% BMI) and normal (5–85% BMI) divided. People in the study were matched for age and sex. Liver enzymes (ALT & AST) and lipid profile were measured and a radiologist who didn't know children's BMI examined them based on fatty liver sonographic parameters. And finally data analyzed using SPSS (Ver-18), ANOVA and Tukey's tests. Sometimes data distribution wasn't normal and Kruskal-Wallis test was used.

Results:

The prevalence of fatty liver was 23/3% in obese children that was higher compared with normal (16/7%) and over weight (16/7%) children. Based on the result of this study the prevalence of fatty liver wasn't significantly different between the sexes. AST was significantly higher in children with normal BMI (p<0.01) as well as cholesterol levels showed there was a significant difference among the three groups.

Conclusion:

Based on developing a large number of obese children in this age to fatty liver, these children should be using weight and waist circumference as an indicator of obesity and measuring LDL and ALT as risk factors of fatty liver disease and have regular screening.
147: THE ROLE OF MEDICAL LIBRARIANS IN PROMOTING EVIDENCE BASE MEDICINE IN IRAN
Authors: Motamedi Fatemeh , Khanjani Narges
Published: May 2024

Background and aims:

Evidence based medicine (EBM) is a systematic process that allows physicians and decision makers to access the most reliable and up to date information for the well-being of their patients and the society. The support of medical librarians is essential in this process. The present article reviews the role of medical librarians in EBM in Iran.

Methods:

In this review, information was gathered by searching different databases including PubMed, Science Direct, SID, Google Scholar and Scopus by these key words: (clinical librarian OR medical librarian OR medical informationist) AND (Evidence-Based Medicine OR Evidence-based practice) AND Iran. Retrieved articles were screened and the relevant articles were chosen.

Results:

Performing a comprehensive search and choosing the best relevant information is an important step in EBM. Librarians and medical informationists play an important role in finding, screening and appraising relevant medical literature and supporting clinicians in answering their medical questions. However, little research has been done in Iran and their role has not been well valued even in university hospitals in Iran.

Conclusion:

Librarians and medical informationists have an important role in improving medical decision making and encouraging the use of up to date literature. They can also help by cooperating in teaching efficient search skills and holding appropriate evidence based medicine journal clubs. Librarians should be used more efficiently to improve the quality of medical services and decrease the cost of medical treatment in Iran.
15: APPLICATION OF ACTION RESEARCH IN IMPROVING ADMINISTRATIVE AND FINANCIAL PROCESSES
Authors: Ahari Alireza Mahboob , Mousazadeh Yalda , Forootan Sara
Published: May 2024

Background and aims:

the administrative and financial activities are the most important affairs in any organization and include all affairs related to assets, staffs, formulating and implementing rules related to staff, supply of equipment and equipment for the organization. According to necessity of documentation and integration the different processes for each organizational unit, the aim of this study was identifying and promoting of administrative and financial processes of Management & Medical informatics faculty, Tabriz University of Medical Sciences.

Methods:

This study was a qualitative research with action research approach. Based on this approach after identifying the problem, planning is done for data collection. Planning includes recognizing the current condition of administrative and financial processes, identifying tasks and job description related to these processes and designing proper process by employee opinions about the process. Interviews were conducted in order to identify current conditions and proper form of process in implementation phase. Proper form of the process was found after negotiation with employee and was shown in the flowcharts. Checklist was used for assessing results.

Results:

There were no documented processes, before the study period. After the interviews, it became clear that employees apply too much personal opinions in all process. After the transcription and assessing interviews, according to job description and employee opinion, proper form of the processes were drawn. totally 44 process was identified and drawn that included 7 process related to public affairs office, 16 process related to staffing process, 2 process related to the secretariat, 12 accounting process and 7 process related to property office.

Conclusion:

In this study, the proper form of all process were identified and presented in the form of a booklet. Correct form and step by step process can avoid from arbitrary and sporadic in affairs, as well as duplication, waste of time and resources and customer dissatisfaction.
151: A LOOK AT THE EDUCATION AND PRACTICE OF EVIDENCE BASED LIBRARIANSHIP (EBL)
Authors: Gavgani Vahideh Zarea , Siamian Hasan
Published: May 2024

Background and aims:

The aim of this study was to find out the educational Model of Evidence Based Library and information Practice in the world. It will answer to the following questions: What are the reputed field names for EBL in other countries? In which levels (course or lesson) it is teaching, currently? Which universities are admitting for EBL? In which degrees EBL is supported? What is the prospect for Iranian Ministry of Health to establish this field of study?

Methods:

The study used citation and library method to find and describe the situation and quality of faculties offering the EBL as course or lesson. Reputed citation databases were searched for evidence and the Google search engine was employed to find and review the websites of universities which are delivering EBL.

Results:

The finding of this study shows that since the emergence of evidence based librarianship in the literature it has witnessed plenty names and currently is known as Evidence Based Library and Information Practice in the literature. It is offered by United States; Canadian and UK based universities in both the course and lesson level of education. It is almost offered in post graduate, post master and post-doctoral model. It has potential to be delivered as essential post master course for every discipline with research base.

Conclusion:

This study suggests a master of evidence based information management for Iran with Ministry of Health and Medical Education license. The best model for Iran would be interdisciplinary model of education by Medical Library and Information Science Department and Iranian Center of Evidence Based Medicine joint execution.
155: A STUDY OF CORRELATION BETWEEN THE USE OF EVIDENCE IN IRANIAN NURSES' CLINICAL JUDGMENT AND DECISION MAKING WITH SOME RELATED FACTORS IN 2015
Authors: Seidi Jamal , Alhani Fatemah , Salsali Mahvash , Kazemnejad Anoushirvan
Published: May 2024

Background and aims:

one of the main factors determining the competency of an individual in clinical judgment and decision making is the way which he/she use available evidences. The present study was set aiming at investigating the use of various evidences for clinical judgment and decision making in nursing career and assessing its relationship with various factors.

Methods:

The present cross-sectional study, which was a research project approved by The National Institute for Health Research at the University of Kurdistan, Iran, was conducted during 2015. A total number of 360 nurses were selected using the multistage cluster sampling method. The tool used for collecting data was composed of three main parts; (1) demographic information and clinical condition, (2) underlying factors (seven items), and (3) the use of various evidences (11 items). A content validity ratio higher than 0.49 and content validity index higher than 0.79 confirmed that the questionnaire was validated. The reliability of the questionnaire was evaluated using the Pearson's correlation coefficient (r=0.92). Finally, the data were analyzed using SPSS software package and various statistical tests, such as Pearson's correlation coefficient and multiple regressions.

Results:

there was observed a negative significant correlation between the level and type of evidence used by individuals with the urgency of the clinical condition (r=–0.58). Further, there was a positive significant correlation between the level and type of evidence used by individuals and their education level (P-value<0.05). However, no significant correlation was found between the use of evidence with age, experience, and gender. Regarding the underlying factors in using evidence, there was a positive significant correlation between the use of evidence with the availability of resources and clinical equipment (r=0.92), educational facilities (r=0.64), management support (r=0.76), organization (r=0.58), and physicians (r=0.84) (P-value<0.05).

Conclusion:

it can be concluded from the present study that the improvement of clinical condition and skills in emergencies and enhancing the availability of required resources and facilities would facilitate the use of evidences. Moreover, it was observed that nurses were less desired to use clinical guidelines and scientific documents, and they preferred to use other tools such as experience, regulations standards, clinical and Para-clinical documents. Hence, it is recommended that the availability of these resources should be promoted.
159: ASSESSMENT OF THE QUALITY OF REPORTING ON RANDOMIZED CONTROLLED TRIALS IN DIABETES BETWEEN HIGH AND LOW IMPACT FACTOR AND SJR JOURNALS
Authors: Aletaha Azadeh , Soltani Akbar , Baradaran Hamid Reza
Published: May 2024

Background and aims:

The primary objective of this study was to evaluate the quality of randomized controlled clinical trial reports in diabetes research in Iran and the secondary objective included identifying any associations between CONSORT quality and surrogate markers of article quality, including high and low impact factor and SJR journals.

Methods:

184 RCTs studies conducted on Diabetes mellitus in Iran. ANOVA and Pearson correlation was used to analyze the relationship among group with each article for reports of (RCTs) conducted on Diabetes mellitus that were index in ISI, Scopus, PubMed or other international journals index based an impact factor and SJR index. For the purposes of this study, we selected all articles published in English and indexed in PubMed, ISI, Scopus and other international journals between 2004 to 2014.

Results:

In all, 269 articles were retrieved from the search of the ten databases. Of these, 184 articles were selected. The mean CONSORT score of the 184 RCTs was 8.11 out of 17 (31.7%, range 6–12, SD 1.38). The poorest-reported items were all item. No paper adequately reported all items in the CONSORT checklist. There was no correlation between the quality of CONSORT score and the IF and SJR Journals (Pearson:-0.065, P: 3.84.29). In addition, there was no statistical difference in CONSORT score between group and within group IF or SJR journal designs (ANOVA: P value: 0.7, the mean CONSORT score of the 184 RCTs was 8.63 from 17 scores).

Conclusion:

In conclusion, our findings suggest that the that the authors, funding agencies, peer reviewers, and journal-editors in RCTs in diabetes has an important role to enhance the quality of RCTs and collaborate to enhance the integration of CONSORT into the RCT publication process Evolution and further extension of CONSORT will hopefully help to incorporate studies with alternative methodologies.
161: BRIDGING BETWEEN PATIENTS PREFERENCE AND EVIDENCE BASED PRACTICE ACCORDING TO GUIDELINES IN OSTEOARTHRITIS MANAGEMENT: A QUALITATIVE STUDY
Authors: Behshid Mozhgan , Zamanzadeh Vahid , Ahmadi Fazlollah , Irajpoor Alireza
Published: May 2024

Background and aims:

Osteoarthritis is the major cause of disability worldwide that causes significant problems in activities of daily living and deeply affects the quality of life. Osteoarthritis is predicted to become one of the major causes of disability in future that necessitates comprehensive global plans for resolving this health issue in accordance with patients' local culture, beliefs and attitudes. This study was a part of PhD dissertation that was conducted to carry out an in-depth examination of the experiences of patients with OA about their use of strategies for the OA self-management and compare them with scientific evidences.

Methods:

The present qualitative study was conducted using a conventional content analysis approach on 33participantincluding patients with OA, their family members and healthcare personnel who were selected by purposive sampling. Data were collected through unstructured and semi-structured interviews and continued until data saturation occurred. Data analysis was carried out simultaneously. Guba and Lincoln's standards of rigor and trustworthiness were respected including the credibility, transferability, dependability and conformability of the data. A narrative systematic review was conducted on osteoarthritis care guidelines and algorithms in order to compare patients' preference with scientific evidences.

Results:

The analysis of the data revealed four main categories, including: Conservative approach in selecting treatment modalities, trend toward traditional treatment, Preferring complementary and alternative medicine, and concerns and barriers treatment modalities. The review of literature demonstrated little attention by professionals to the patients' values or priorities. Comparing of the modalities that were preferred by patients with scientific guidelines indicated some inconsistencies.

Conclusion:

Patient's perceptions, preference, and adherence to treatment, play an essential role in relieving nagging symptoms and treatments outcomes. Although guidelines are used to define best practices in osteoarthritis care, patient preference that derived from their local culture, beliefs and attitudes should be considered to operationalization. Participating the patients on the therapeutic goal setting as well as clinical decision-making, and supervising the use of complementary treatments are recommended. Patients should be involved in the development of clinical practice guidelines.
17: ASSESSING THE BARRIERS TO EVIDENCE-BASED PRACTICE FROM THE PERSPECTIVE OF NURSES IN INTENSIVE CARE UNITS SOCIAL SECURITY HOSPITALS IN TABRIZ
Authors: Sakhlou Zakiyeh Imani , Foroughei Masoumeh Ranjbar , Khameslou Mehdi Ajri
Published: May 2024

Background and aims:

In intensive care unit, patients' conditions are more complex and more likely to be at risk of complications and death; therefore, implementing of interventions based on the best evidence is the key issue for nurses. Bridging the gap between scientific evidence and patient care is necessary to accurately identify barriers so; the aim of this study was to determine the barriers to implementing evidence-based care from nurse's view-point in intensive care, social security hospitals in Tabriz.

Methods:

This is a descriptive- analytical research in which 60 nurses working in intensive care units (ICU, CCU, Dialysis) of social security hospitals in Tabriz participated using census sampling and barriers to implementing EBP were examined using a Funk's EBP Barriers scale which is divided into four subscales: subscales erelated to Nurses, hospital or organization, the quality of research and subscale on how to submit the findings of research. The data were analyzed by descriptive statistical tests (chi-square and Fisher). The significance level of 0.05 was considered in the statistical analysis.

Results:

The average age of the samples was 36.34. Mostly women (71.2%), mostly undergraduate education (89.8%) and mostly with formal employment status (94.9%) were. Subscale of the Nurses had no significant relationship with any of the variables. Subscale related to organization, with age, education amount and employment status, subscale related to the quality of research with education amount and subscale on how to submit the findings of research with age, gender, work experience and employment status had significant relationship. Overall, education amount and employment status had significant relationship with barriers to implementing evidence-based practice, in this way the nurses had formal employment status and higher education, did more evidence-based care.

Conclusion:

It is necessary hospitals provide conditions that research and using the results to be given priority. Only nursing education and giving them more authority couldn't be sufficient to implement research findings in clinical practice so, organizational climates of hospitals need to change and reform.
182: IRANIAN ACADEMIC'S VIEWPOINT CONCERNING RESEARCH SOCIAL NETWORKS (RSNS)
Authors: Abdekhoda Mohammadhiwa , Salehi Narges , Gavgani Vahide zare
Published: May 2024

Background and aims:

Research Social Network (RSNs), resulted from the emergence of Web 2, allows researchers to present their works, to communicate with other colleges, to create new discoveries, and to collaborate. This study aimed to survey the Iranian academic's viewpoint concerning Research Social Networks (RSNs).

Methods:

This was a descriptive study in which 250 researchers from Kerman University of Medical Sciences were selected by stratify randomized modeling. Iranian researcher's viewpoint concerning the Mission, Goals and capabilities of Research Social Networks (RSNs), were studied by a researcher-developed questionnaire. Collected data were analyzed by SPSS software (version 16) using descriptive statistics.

Results:

The results showed that majority of participants (65 percent) are familiar with the RSNs and have their accounts on them. The data also revealed that Iranian academics have affirmative viewpoint regarding RSNs Mission, goals and its capabilities. Participants use RSN to meet new researchers (71 percent), find information (55 percent), sharing experience (52 percent), and contribute in discussions (35 percent).

Conclusion:

RSNs are valuable and useful for Iranian academics and is great opportunity to associate with other researches in global network of sciences. Well-designed and properly supported RSNs infrastructures and encouraged researchers to joint RSNs should be considered by mangers and policy makers.
193: RELIABILITY AND ACCEPTABILITY OF THE REFERENCES OF THE ARTICLES IN THE FIELD OF PEDIATRICS NUTRITION ON UP-TO-DATE DATABASE BASED ON BIBLIOMETRIC AND ALTMETRICS
Authors: Ghazavi Roghayeh , Mazaheri Elaheh
Published: May 2024

Background and aims:

Considering that Up-to-date database is one of the well-known and reliable databases in the field of evidence-based medicine (EBM), it is expected that the referred papers in the articles are the valid ones on the topic concerned. The aim of this study was to evaluate the credibility and acceptability of the references of the Articles in the Field of Pediatrics Nutrition on Up-to-date Database based on bibliometric and altmetrics indexes.

Methods:

The studied articles were retrieved from database by searching word “nutrition” in the field of “Pediatrics”. After assessing the first 100 retrieved articles, 30 articles were selected with more relevancies. In the next phase, the indexes of all 1934 references used in 30 articles, which were in the Scopus database, extracted and entered in the prepared checklist. These indicators involved bibliometrics indexes such as Citation Count, Field-Weighted Citation Impact, and Citation Benchmarking as well as altmetrics indexes like Scholarly Activity (Mendeley and CiteULike), Scholarly Activity benchmarking, Scholarly Commentary (Blogs, Reviews), Mass Media, Social Activity (Twitter, Facebook) and Social Activity benchmarking. In addition, in order to determine the validity of the journals that publish these papers, SJR, IPP and SNIP indexes were extracted from Scopus database and entered the checklist.

Results:

The mean of Citation Benchmarking, Scholarly Activity benchmarking and Social Activity benchmarking with percentile of 80.5, 70 and 12.8, respectively indicated that validity of the used articles in terms of bibliometrics indexes had relatively good condition; but regarding to altmetrics indexes, in Scholarly Activity and Social Activity were in moderate and weak conditions, respectively. SJR and SNIP indexes of the journals with an average mean of 2.5 also indicated a moderate status for used journals.

Conclusion:

Due to the fact that the use of articles in the scientific community allocate more importance to determine their reliability and acceptability, high ranking of this index is a positive point, but it is still necessary to increase this rank with further use of the articles in the top percentile. The gap between scientific and social indexes is very high; this also demands more assessment of high percentile articles of these indexes in order to determine the cause of this difference.
197: THE EFFECT OF FISH-OIL SUPPLEMENTATION ON MATERNAL AND NEONATAL OUTCOMES: A TRIPLE BLIND RANDOMIZED CONTROLLED TRIAL
Authors: Khalili Azizeh Farshbaf , Ostad-Rahimi Alireza , Pourmehr Hanieh Salehi , Malakouti Jamileh , Agdam Nayyer Jafarilar , Shahrisa Elham
Published: May 2024

Background and aims:

To evaluate the effect of fish oil supplementation on pregnancy outcomes in mother and newborn.

Method:

This randomized, triple-blinded placebo-controlled trial was conducted on 150 pregnant women aged 18–35 from February 2014 to April 2015 in Tabriz, Iran. Participants assigned to receive either 1000 mg fish oil supplements containing 180 mg eicosapentaenoic acid and 120 mg docosahexanoic acid from week 20 of gestation to birth. Primary outcome measure was birth weight. Gestational duration, preterm labour, low birth weight (LBW), length, and head circumference, maternal serum DHA and EPA level at 35–37 weeks were also examined. The statistical analysis was intent-to-treat.

Results:

Demographic characteristics were similar in both groups (P>0.05). The mean (SD) birth weight in the fish oil and placebo groups were 3256g (362) and 3172g (447), respectively (adjusted MD=84.1g; [95% CI –24.8, 193.2]). Five (7.6%) neonates in the placebo versus no case in the fish oil group were born with LBW (p=0.02). The rate of preterm labour was lower in the fish oil group (adjusted OR=0.74; [95% CI 0.16, 3.42]). However, there were no statistically significant differences in the maternal outcomes (P>0.05) with exception of the proportion of maternal serum DHA fatty acid at 35–37 weeks (P<0.001).

Conclusion:

Although low dose fish oil supplementation increased birth weight, its effect was not statistically significant. The frequency of LBW was significantly reduced in the intervention group but the observed reduction needs to be confirmed in future larger investigations using different doses of omega-3.
2: A PILOT STUDY OF EVALUATION OF GUIDELINES ADHERENCE FOR LATENT TUBERCULOSIS INFECTION PATIENTS USING TNF-ANTAGONISTS IN A MEDICAL CENTER IN TAIWAN
Authors: Lin Chih-Sheng , Yao Man-Lih , Chen Chih-Fang , Lee Wei-Ying
Published: May 2024

Background and aims:

Use of anti-TNF agents increases the risk of TB, especially in Asian countries. The guideline suggested that the treatment of latent TB infection (LTBI) is recommended with oral isoniazid (INH) nine months and used TNF-α antagonist four weeks after treatment. However, the TB infection prevention by using TNF-α antagonist remains unclear in Taiwan. We evaluated the adherence rates of patients received anti -TNF agents with latent tuberculosis infection (LTBI) prophylaxis treatment.

Methods:

Retrospectively collected the medical records of outpatient received adalimumab from Jan. 2014 to Dec. 2015. Brio Query version 6 as a computer program to collect patient information

Results:

There are 49 patients included in this study. Eighteen percent (9/49) of the patients received LTBI prophylaxis. Seventy eight percent (7/9) patients were found of positive QuantiFERON test, and 22% (2/9) revealed intermediate results. One of the patient with Anti-HBc (+) and HCV (+) ceased treatment four months later. He was found of ALT level increase to 98 IU/L while taking INH again in the first month. The liver function returned to normal after INH discontinuation. The other 89% (8/9) completed 9 months treatment course. One of them is hepatitis B carrier with liver function impairment after taking medicine for six months. This individual case was done in closely monitored by doctor, and hepatic function return to normal three months after treatment.

Conclusion:

This study shows the risk of INH-induced liver function impairment is higher than the other country. The QuantiFERON testing are highly recommend if patients taking TNF-α inhibitor and another therapy instead seems to be more in line with prophylaxis for tuberculosis in Taiwan.
201: THE QUALITY ASSESSMENT OF STUDIES OF DIAGNOSTIC ACCURACY PUBLISHED IN THE CANCER JOURNALS
Authors: Azizi Hanieh , Khodashenas Shiva , Pirmohammadi Saeedeh , Lotfipour Tohid
Published: May 2024

Background and aims:

A cancer diagnosis is life-damaging on many levels, and people react to the diagnosis and treatment of cancer differently and receiving a cancer diagnosis is a stressful event all over the world. Our aim is to evaluate the quality of reporting of all diagnostic studies published in two major cancer journals using the Standards for Reporting of Diagnostic Accuracy (STARD) initiative parameters.

Methods:

we hand-searched Cancer Journal for Clinicians and Cancer Medicine journals for all abstracts of diagnostic studies published. They independently assessed the reporting quality of the English version of all eligible abstracts based on a modified version of the STARD. The STARD checklist of 25 items and flow chart was used to evaluate the quality of each publication.

Results:

We totally found 739 articles. All studies were published between 1996–2015. A total of 27 publications were included as diagnostic studies. There were 21 articles that have cheeked more than half of STARD checklist items on them. The most checked item was state the research questions with 21 cheeks and the least cheeked item was report the determination of the results with 3 cheeks on it.

Conclusion:

The reporting quality of abstracts of diagnostic accuracy in the Cancer Journal for Clinicians and Cancer Medicine journals needs to be improved the current standards of reporting of diagnostic accuracy tests are highly variable. The STARD initiative may be a useful tool for appraising the strengths and weaknesses of diagnostic accuracy studies.
202: THE RELATION BETWEEN IRANIAN MEDICAL SCIENCE RESEARCH IN WEB OF SCIENCE DATABASE AND BURDEN OF DISEASE IN IRAN
Authors: Foroughi Zahra , Davodi Ali , Alizadeh-Navaei Reza
Published: May 2024

Background and aims:

Scientific productions have been accelerated in Iran in past decades but their association with health problems and disease burden is doubtful. The aim of this study was to assess the relationship between Iranian scientific productions (published in 2010–2015) with disease burden in Iran using Web of Science database.

Methods:

Data was collected using Scientometric indicators, direct observation, and note taking. The current research included all articles written by Iranian researchers during 2010 to 2015which were published in Web of Science – indexed journals. The search was limited to the affiliation ‘Iran’ and was performed using different keywords including road accident, ischemic heart diseases, major depression disorders, and cerebral vascular diseases, Back Pain, Osteoarthritis, Knee, Anemia, Iron-Deficiency, Bipolar Disorder and Pulmonary Disease, Chronic Obstructive. These were believed to have the highest disease burden. Then, the scientometric outputs were recorded and the relationship between scientific productions with disease burden was investigated.

Results:

In total, 1800 articles had been published in Web of Science – indexed journals. Among them depression disorders and Cerebrovascular Disorders had the highest (1296 records) and lowest (18 records) records, respectively. Major depression disorders were found to have the greatest h-index and the highest percentage of scientific productions with at Average Citations per Year was associated with Major depression. There was a direct correlation between years of life lost due to premature mortality (r=0.8, P=0.2), years lived with disability (r=0.333, p=0.381), with scientific productions.

Conclusion:

our results showed Iranian scientific productions in Web of Science data set are not related to disease burden.