bluuebunny/crossref_metadata_2025 huggingface dataset:
Study on Ultrasonic Characteristics and Prediction of Rock with Different Pore Sizes
Authors: Wang Lei , Nie Wen , Xie Ming , Wang Zi , Lu Wei , Chen Dongmei , Lin Weinan
Published: May 2024

The internal defects of rocks are the main cause of instability and failure in underground engineering. Therefore, using ultrasonic monitoring technology to study the defect characteristics of rocks containing voids is of great significance. The research results indicate that with the increase in the pore size, the longitudinal wave velocity and first wave amplitude of rocks containing voids decrease, the attenuation coefficient increases, and the difference in ultrasonic parameters between rocks containing voids and intact rocks increases, resulting in a significant decrease in the rock integrity. The propagation of ultrasonic waves in porous rocks can be divided into three stages, where obvious ultrasonic reflection, diffraction, and scattering occur. The attenuation of sound pressure is significant, and the ultrasonic sound pressure is negatively linearly correlated with the pore size. Based on the amplitude, velocity, and pressure of ultrasonic waves, an ANN‐based method for predicting the pore size of rocks is proposed, which inverts and predicts the pore size of rock masses with high prediction accuracy.
Electronically Tunable Grounded and Floating Capacitance Multipliers Using a Single Active Element
Authors: Seechaiya Nuttapon , Jaikla Winai , Chaichana Amornchai , Silapan Phamorn , Supavarasuwat Piya , Suwanjan Peerawut
Published: May 2024

A capacitance multiplier is an active circuit designed specifically to increase the capacitance of a passive capacitor to a significantly higher capacitance level. In this paper, the use of a voltage differencing differential difference amplifier (VDDDA), an electronically controllable active device for designing grounded and floating capacitance multipliers, is proposed. The capacitance multipliers proposed in this study are extremely simple and consist of a VDDDA, a resistor, and a capacitor. The multiplication factor (Kc) can be electronically controlled by adjusting the external bias current (IB). It offers an easy way of controlling it by utilizing a microcontroller for modern analog signal processing systems. The multiplication factor has the potential to be adjusted to a value that is either less than or greater than one, hence widening the variety of uses. The grounded capacitance multiplier can be easily transformed into a floating one by utilizing Zc-VDDDA. PSpice simulation and experimentation with a VDDDA realized from commercially available integrated circuits were used to test the performance of the proposed capacitance multipliers. The multiplication factor is electronically adjustable, ranging in approximation from 0.56 to 13.94. The operating frequency range is approximately three frequency decades. The realization of the lagging and leading phase shifters using the proposed capacitance multiplier is also examined and proven. The results reveal that the lagging and leading phase shifts are electronically tuned via the multiplication factor of the proposed capacitance multipliers.
Bioequivalence and Safety of Two Formulations of Tofacitinib Citrate Tablets in Healthy Chinese Volunteers under Fasting and Fed Conditions: Randomized, Open‐Label, 2‐Period, Single‐Dose, Crossover Trials
Authors: Liu Yanping , Ning Yuping , Shi Yan , Xu Man , Tao Juanmin , Dong Yafen , Ma Jun , Qiu Yan
Published: May 2024

Purpose. To evaluate the bioequivalence of two different tofacitinib citrate tablets formulations among healthy Chinese subjects under fasting and fed conditions and to observe the safety of test preparation and reference preparation in healthy subjects. Method. This randomized, open‐label, 2‐period, crossover, bioequivalence study included 64 healthy Chinese subjects (fasting: n = 32, fed: n = 32). The subjects were assigned to receive a single 5‐mg dose of the test or a reference tofacitinib citrate tablets. Blood samples were collected at predose and up to 24 hours after dosing. Area under the plasma concentration time curve from zero to the last measurable concentration (AUC0-t), the area from time zero to infinite (AUC0-∞), and maximum plasma concentration (Cmax) were used for bioequivalence assessment. Safety assessment was conducted by vital signs, physical examination, laboratory examination, and 12‐lead electrocardiogram during the study, from the time the subject receiving the test drug to the end of the last visit. Results. Under fed condition, the 90% CIs of the geometric mean ratios of the test/reference for tofacitinib citrate tablets were 98.40–104.16% for AUC0-t, 89.96–116.70% for Cmax, and 98.50–104.15% for AUC0-∞. Under fasting condition, the 90% CIs of the geometric mean ratios of the test/reference for tofacitinib citrate tablets were 93.65–101.60% for AUC0-t, 90.06–109.15% for Cmax, and 93.88–101.51% for AUC0-∞. There were no serious events. Conclusion. The 90% CI for the geometric mean ratio (test/reference) of Cmax, AUC0-t, and AUC0-∞ were within the range of 80.00%–125.00%, indicating that the test formulation was equivalent to the reference formulation in healthy Chinese subjects under both fasting and fed conditions. They are similar in terms of safety. This trial is registered with CTR20190366.
STAT3 Expression and Its Correlation with PD‐L1 Expression in Non‐Hodgkin’s Lymphoma and Hodgkin’s Lymphoma at Dr. Saiful Anwar Regional Public Hospital in Malang, Indonesian Population
Authors: Hambalie Ailen Oktaviana , Norahmawati Eviana , Endharti Agustina Tri , Retnani Diah Prabawati , Rahmadiani Nayla
Published: May 2024

Background. Lymphomas are malignant lymphocyte neoplasms that globally account for 10% of cancers in individuals aged <20 years. Malignant lymphomas are divided into Hodgkin’s lymphoma (HL) and non‐Hodgkin’s lymphoma (NHL). Despite the availability of many therapeutic modalities for lymphoma, such as Brentuximab vedotin, Nivolumab, and Pembrolizumab, it is still necessary to identify appropriate strategies with minimal side effects. Immunotherapy is a promising approach, exemplified by targeting JAK/STAT3 signaling, which can inhibit tumor growth and enhance antitumor immune responses. Hence, STAT3 (signal transducer and activator of transcription 3) is a promising therapeutic target. PD‐L1 (programmed death-ligand 1), an immune checkpoint molecule, is used as a frontline treatment for various cancers. This study aims to determine STAT3 expression and its correlation with PD‐L1 expression in NHL and HL to serve as a basis for further research on anti‐STAT3 and its combination with other therapy targets. Methods. Samples were obtained from paraffin blocks of patients with confirmed diagnoses of NHL and HL, and then immunohistochemical staining was carried out with PD‐L1 and STAT3 antibodies. The collected data were then analyzed using SPSS. Results. Among the 10 HL patients, no patients (0%) expressed STAT3, while nine patients (90%) expressed PD‐L1. Among the 10 NHL patients, 1 patient (10%) expressed STAT3, while six patients (60%) expressed PD‐L1. There were no significant differences in STAT3 expression and PD‐L1 expression between HL patients and NHL patients. There was no correlation between STAT3 and PD‐L1 expression in HL and NHL because almost all STAT3 expressions were negative. Conclusion. Although this study revealed no differences between STAT3 and PD‐L1 expression in HL and NHL and no significant correlation between STAT3 and PD‐L1 expression in HL and NHL, this may serve as the basis for understanding the role of STAT3 and PD‐L1 in the regulation of HL and NHL, which may be useful for further research targeting STAT3 and PD‐L1 immunotherapy in HL and NHL.
FAP Serves as a Prognostic Biomarker in Head and Neck Squamous Cell Carcinoma
Authors: Liao Zhanpeng , Fan Haidong , Weng Junquan , Zhou Jieyu , Zheng Yuyan
Published: May 2024

Head and neck squamous cell carcinoma (HNSCC) poses significant challenges with poor survival rates and limited therapeutic strategies. Our study, using The Cancer Genome Atlas (TCGA) data, assesses cancer‐associated fibroblast (CAF) gene signatures’ clinical relevance. In our analysis across TCGA tumor types, differential gene expression analysis revealed that fibroblast activation protein (FAP) is upregulated in tumor tissues and associated with poorer survival rates in HNSCC. Furthermore, mechanistic studies employing gene‐silencing techniques substantiated that FAP knockout led to a significant decrease in cellular proliferation, invasion, and migration in HNSCC cell lines. Through Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses, we established that high FAP expression correlates with vital biological processes such as extracellular matrix organization, angiogenesis, and cellular motility. Importantly, FAP was found to regulate these processes by promoting the expression of key proteins involved in epithelial–mesenchymal transition‐related pathways. Additionally, our analysis revealed a significant correlation between FAP expression and the expression profiles of immune checkpoint molecules, underscoring its potential role in immune modulation. Collectively, our findings illuminate FAP’s pivotal role in HNSCC pathogenesis and its potential as a prognostic biomarker and therapeutic target. This research lays the groundwork for understanding the multifaceted roles and regulatory mechanisms of CAFs in HNSCC, thereby offering valuable perspectives for the development of targeted therapeutic strategies aimed at improving patient outcomes.
Giant Ganglioneuroma of the Lumbar Spine: A Rare Cause of Radiculopathy
Authors: Altalhi Lina , Alayyaf Abdulaziz , Bin-Mahfooz Mohammed , Alhumoudi Duaa , Alkhaibary Ali , AlSufiani Fahd , Alassiri Ali H. , AlQahatani Saad , Khairy Sami , Alkhani Ahmed
Published: May 2024

Background. Ganglioneuroma (GN) is a rare, benign tumor that originates from neural crest cells and can potentially affect any anatomical site within the sympathetic nervous system. Typically, GNs are more frequently reported in children and young adults, with a slightly higher prevalence in females. We are reporting a rare case of a giant lumbar spine ganglioneuroma by outlining the clinical presentation, radiological finding, management, and outcome. Case Description. A 37‐year‐old female presented with low back pain radiating to the right lower limb for few years. Neurological examination revealed bilateral lower limb hyperreflexia (+3). Lumbar spine CT and MRI revealed a right paravertebral soft tissue lesion with heterogeneous signal intensity and enhancement at L1 to L3. The patient underwent complete resection of the lesion via a retroperitoneal approach. The surgery was uneventful. The histopathological sections were suggestive of mature ganglioneuroma. She was discharged in stable condition with follow‐up at neurosurgery clinic. Conclusion. Giant ganglioneuromas are rare, benign tumors of sympathetic neurons. Complete surgical resection is the most effective therapeutic option for ganglioneuroma to avoid recurrence. Given the benign nature of ganglioneuroma, chemotherapy and radiotherapy tend to have a limited role following surgical resection.
Targeting Acute Myeloid Leukemia Stem Cells through Perturbation of Mitochondrial Calcium
Authors: Sheth Anagha Inguva , Althoff Mark J. , Tolison Hunter , Engel Krysta , Amaya Maria L. , Krug Anna E. , Young Tracy N. , Minhajuddin Mohammad , Pei Shanshan , Patel Sweta B. , Winters Amanda , Miller Regan , Shelton Ian T. , St-Germain Jonathan , Ling Tianyi , Jones Courtney L. , Raught Brian , Gillen Austin E. , Ransom Monica , Staggs Sarah , Smith Clayton A. , Pollyea Daniel A. , Stevens Brett M. , Jordan Craig T.
Published: May 2024

Acute myeloid leukemia stem cells (LSCs) are uniquely reliant on oxidative phosphorylation (OXPHOS) for survival. Moreover, maintenance of OXPHOS is dependent on BCL-2, creating a therapeutic opportunity to target LSCs using the BCL-2 inhibitor venetoclax. Although venetoclax-based regimens have shown promising clinical activity, the emergence of drug resistance is prevalent. Thus, in the present study, we investigated how mitochondrial properties may influence venetoclax responsiveness. Our data show that utilization of mitochondrial calcium is fundamentally different between drug-responsive and nonresponsive LSCs. By comparison, venetoclax-resistant LSCs demonstrate an active metabolic (i.e., OXPHOS) status with relatively high levels of calcium. Consequently, we tested genetic and pharmacological approaches to target the mitochondrial calcium uniporter. We demonstrate that inhibition of calcium uptake reduces OXPHOS and leads to eradication of venetoclax-resistant LSCs. These findings demonstrate a central role for calcium signaling in LSCs and provide an avenue for clinical management of venetoclax resistance.

Significance: We identify increased utilization of mitochondrial calcium as a distinct metabolic requirement of venetoclax-resistant LSCs and demonstrate the potential of targeting mitochondrial calcium uptake as a therapeutic strategy.
A queda da Marquesa D'Ancre impressa dos dois lados do Canal da Mancha (1617)
Authors: Liebel Silvia
Published: May 2024

Em 24 de abril de 1617, chegava ao fim a prodigiosa influência de um casal de italianos sobre a regente da França, Marie de Médicis. Ao articular o assassinato do marquês d’Ancre, marechal da França e figura-chave na condução dos negócios do reino, o delfim Louis XIII garantiu sua ascensão ao trono e o isolamento da rainha-mãe, apoiando-se sobre a distribuição das riquezas do falecido entre seus apoiadores. Restava, contudo, a questão em torno do que fazer com a viúva Léonora Dori, herdeira legítima de Concini. Através da análise das representações da marquesa em folhetos franceses e ingleses, este artigo reconstrói as facetas que lhe foram atribuídas e as visões contrastantes em torno de seu grau de influência na França do início do século XVII. No entrecruzamento entre a História do Impresso, a História das Mulheres e a História das Emoções, este artigo se volta à reflexão sobre a mobilidade dos textos e o impacto dos impressos baratos na constituição de um dado imaginário em torno do feminino e da formação da opinião na França moderna.
Endovascular Versus Medical Management in Distal Medium Vessel Occlusion Stroke: The DUSK Study
Authors: Mohammaden Mahmoud H. , Souza Viana Lorena , Abdelhamid Hend , Olive-Gadea Marta , Rodrigo-Gisbert Marc , Requena Manuel , Martins Pedro N. , Matsoukas Stavros , Schuldt Braxton R. , Fifi Johanna T. , Farooqui Mudassir , Vivanco-Suarez Juan , Ortega-Gutierrez Santiago , Klein Piers , Abdalkader Mohamad , Vigilante Nicholas , Siegler James E. , Moreira Ferreira Felipe , Peng Sophia , Alaraj Ali , Haussen Diogo C. , Nguyen Thanh N. , Nogueira Raul G.
Published: May 2024

BACKGROUND:

Endovascular treatment (EVT) is part of the usual care for proximal vessel occlusion strokes. However, the safety and effectiveness of EVT for distal medium vessel occlusions remain unclear. We sought to compare the clinical outcomes of EVT to medical management (MM) for isolated distal medium vessel occlusions.

METHODS:

This is a retrospective analysis of prospectively collected data from seven comprehensive stroke centers. Patients were included if they had isolated distal medium vessel occlusion strokes due to middle cerebral artery M3/M4, anterior cerebral artery A2/A3, or posterior cerebral artery P1/P2 segments. Patients treated with EVT or MM were compared with multivariable logistic regression and inverse probability of treatment weighting. The primary outcome was the shift in the degree of disability as measured by the modified Rankin Scale (mRS) at 90 days. Secondary outcomes included 90-day good (mRS score, 0–2) and excellent (mRS score, 0–1) outcomes. Safety measures included symptomatic intracranial hemorrhage and 90-day mortality.

RESULTS:

A total of 321 patients were included in the analysis (EVT, 179; MM, 142; 40.8% treated with intravenous thrombolysis). In the inverse probability of treatment weighting model, there were no significant differences between EVT and MM in terms of the overall degree of disability (mRS ordinal shift; adjusted odds ratio [aOR], 1.25 [95% CI, 0.95–1.64];
P
=0.110), rates of good (mRS score, 0–2; aOR, 1.32 [95% CI, 0.97–1.80];
P
=0.075) and excellent (aOR, 1.32 [95% CI, 0.94–1.85];
P
=0.098) outcomes, or mortality (aOR, 1.20 [95% CI, 0.78–1.85];
P
=0.395) at 90 days. The multivariable regression model showed similar findings. Moreover, there was no difference between EVT and MM in rates of symptomatic intracranial hemorrhage in the multivariable regression model (aOR, 0.57 [95% CI, 0.21–1.58];
P
=0.277), but the inverse probability of treatment weighting model showed a lower likelihood of symptomatic intracranial hemorrhage (aOR, 0.46 [95% CI, 0.24–0.85];
P
=0.013) in the EVT group.

CONCLUSIONS:

This multicenter study failed to demonstrate any significant outcome differences among patients with isolated distal medium vessel occlusions treated with EVT versus MM. These findings reinforce clinical equipoise. Randomized clinical trials are ongoing and will provide more definite evidence.
Infection and Pediatric Arterial Ischemic Stroke Presumably Related to Focal Cerebral Arteriopathy: Data From the COVID-19 Pandemic
Authors: Tudorache Raluca , Jaboyedoff Manon , Gabet Amélie , Olié Valérie , Angoulvant François , Tuppin Philippe , Lesuffleur Thomas , Kossorotoff Manoelle
Published: May 2024

BACKGROUND:

Infection may trigger pediatric arterial ischemic stroke (PAIS), notably when related to focal cerebral arteriopathy. Community- and individual-level nonpharmaceutical interventions during the COVID-19 pandemic resulted in a major decrease in pediatric viral infections. We explored the consequences on the incidence of PAIS.

METHODS:

Using national public health databases, we identified children hospitalized between 2015 and 2022 with PAIS. Using an age proxy (29 days to 7 years) and excluding patients with cardiac and hematologic conditions, we focused on children with PAIS presumably related to focal cerebral arteriopathy or with no definite cause. Considering the delay between infection and PAIS occurrence, we compared a prepandemic reference period, a period with nonpharmaceutical interventions, and a post-nonpharmaceutical intervention period.

RESULTS:

Interrupted time-series analyses of the monthly incidence of PAIS in this group showed a significant decrease in the nonpharmaceutical intervention period compared with the prepandemic period: −33.5% (95% CI, −55.2%, −1.3%);
P
=0.043.

CONCLUSIONS:

These data support the association between infection and PAIS presumably related to focal cerebral arteriopathy.
The Freedom of Thought, Conscience, and Religion in the Age of Neuroscience
Authors: Relaño Pastor Eugenia
Published: May 2024

While the prominence of neuroscience and neurotechnologies has generated intensive debates about the normative analysis of the ethical-legal challenges in public opinion and academia, these debates are relatively scarce among law and religion experts. To overcome the shortfall, this contribution describes the impact of the main neuroscientific applications on the right of freedom of thought, conscience, and religion. Considering how neurosciences techniques can alter the mind, decode thoughts, and enhance cognitive functions, particularly individual thought and conscience, I suggest revising the traditional dichotomy of forum internum and forum externum of the right to freedom of thought, conscience, and religion and rethinking the protection of the forum internum, which is at risk in the Age of Neuroscience.
Edible cockroaches as food and feed – A systematic review on health benefits, nutritional aspects and consumer acceptance
Authors: Siddiqui S.A. , Hadus M.C.I. , Fitriani A. , Guleria V. , Kuppusamy S. , Bhattacharjee B. , Yudhistira B. , Maggiolino A.
Published: May 2024

Cockroaches have been the subject of scientific investigation due of their potential as a protein source. While cockroaches are commonly associated with a repulsive image and can pose as pests in residential environments, several kinds of cockroaches have been classified as edible. There are several commonly encountered species of cockroaches, including Periplaneta americana Linnaeus, 1758, Periplaneta australasiae Fabricius, 1775, Blaberus craniifer Burmeister, 1838, Blatta orientalis Linnaeus, 1758, Neostylopyga rhombifolia Stoll, 1813, and Periplaneta fuliginosa Serville, 1839. While there is not universal acceptance of cockroaches as a food source, a significant number of individuals from many countries have developed a cultural practice of consuming them. The nations encompassed within this group are Vietnam, Thailand, and Mexico. The utilization of cockroach as a potential protein substitute is linked to its substantial nutritional composition, particularly its high protein and amino acid content. This paper offers a detailed overview of cockroaches, encompassing their characteristics, nutritional composition, bioactive properties, the utilization of cockroaches as a food source, processed food derived from cockroaches, their cultivation, and potential adverse effects associated with the consumption of cockroaches. This publication is anticipated to serve as a valuable reference for comprehending the utilization of cockroaches as a constituent in food.
Turning Night into Day: The Creation and Validation of Synthetic Nighttime Visible Imagery Using the Visible Infrared Imaging Radiometer Suite (VIIRS) Day–Night Band (DNB) and Machine Learning
Authors: Pasillas Chandra M. , Kummerow Christian , Bell Michael , Miller Steven D.
Published: May 2024

Meteorological satellite imagery is a critical asset for observing and forecasting weather phenomena. The Joint Polar Satellite System (JPSS) Visible Infrared Imaging Radiometer Suite (VIIRS) Day–Night Band (DNB) sensor collects measurements from moonlight, airglow, and artificial lights. DNB radiances are then manipulated and scaled with a focus on digital display. DNB imagery performance is tied to the lunar cycle, with the best performance during the full moon and the worst with the new moon. We propose using feed-forward neural network models to transform brightness temperatures and wavelength differences in the infrared spectrum to a pseudo-lunar reflectance value based on lunar reflectance values derived from observed DNB radiances. JPSS NOAA-20 and Suomi National Polar-Orbiting Partnership (SNPP) satellite data over the North Pacific Ocean at night for full moon periods from December 2018 to November 2020 were used to design the models. The pseudo-lunar reflectance values are quantitatively compared to DNB lunar reflectance, providing the first-ever lunar reflectance baseline metrics. The resulting imagery product, Machine Learning Nighttime Visible Imagery (ML-NVI), is qualitatively compared to DNB lunar reflectance and infrared imagery across the lunar cycle. The imagery goal is not only to improve upon the consistent performance of DNB imagery products across the lunar cycle, but ultimately to lay the foundation for transitioning the algorithm to geostationary sensors, making global continuous nighttime imagery possible. ML-NVI demonstrates its ability to provide DNB-derived imagery with consistent contrast and representation of clouds across the full lunar cycle for nighttime cloud detection.

Significance Statement

This study explores the creation and evaluation of a feed-forward neural network to generate synthetic lunar reflectance values and imagery from VIIRS infrared channels. The model creates lunar reflectance values typical of full moon scenes, enabling quantifiable comparisons for nighttime imagery evaluations. Additionally, it creates imagery that highlights low clouds better than its infrared counterparts. Results indicate the ability to create visually consistent nighttime visible imagery across the full lunar cycle for the improved nighttime detection of low clouds. Wavelengths chosen are available on both polar and geostationary satellite sensors to support the utilization of the algorithm on multiple sensor platforms for improved temporal resolution and greater simultaneous geographic coverage over polar orbiters alone.
Palliative Intervention for Malignant Bowel Obstruction Comes at a Cost: A National Inpatient Study
Authors: Sun Beatrice J. , Tennakoon Lakshika , Spain David A. , Lee Byrne
Published: May 2024

Background: Malignant bowel obstruction (MBO) due to peritoneal carcinomatosis (PC) is associated with poor outcomes. Optimal management for palliation remains unclear. This study aims to characterize nonoperative, procedural, and operative management strategies for MBO and evaluate its association with mortality and cost.

Materials and Methods: ICD-10 coding identified patient admissions from the 2018 to 2019 National Inpatient Sample (NIS) for MBO with PC from gastrointestinal or ovarian primary cancers. Management was categorized as nonoperative, procedural, or surgical. Multivariate analysis was used to associate treatment with mortality and cost.

Results: 356,316 patient admissions were identified, with a mean age of 63 years. Gender, race, and insurance status were similar among groups. Length of stay (LOS) was longest in the surgical group (surgical: 17 days; procedural: 14 days; nonoperative: 7 days; P = .001). In comparison to nonoperative, procedural and surgical patients had statistically higher hospital charges, post-discharge medical needs, palliative care consults, and admission to rehab centers. Mortality was 7% in nonoperative, 9% in procedural, and 8% in surgical ( P = .007) groups. In adjusted analyses, older age, palliative care consult, and non-Medicare payer status were associated with higher mortality. Compared to nonoperative, procedural and surgical groups resulted in increased costs (procedural: $17K more; surgical: $30K more).

Conclusions: Admissions for procedural and surgical treatment of MBO are associated with increased LOS, hospital costs, and discharge needs. Optimal management remains challenging. Clinicians must examine all options prior to recommending palliative interventions given a trend towards higher resource utilization and mortality.
FAST and Furious About Quality: Impact of Continuous Review and Feedback on Point-of-Care Ultrasound Examinations
Authors: Reis Nicholas C. , Handspiker Erin A. , Bauerle Wayne B. , Reese Vanessa , Benton Adam J. , Castillo Roberto C. , Robins Lisa K. , Ramirez Christine L. , Braverman Maxwell A. , Thomas Peter G.
Published: May 2024

Background: Focused Assessment with Sonography in Trauma (FAST) examination is a point-of-care ultrasound study used to evaluate for abdominal hemorrhage, pneumothorax, or pericardial blood in trauma patients as an adjunct to their initial assessment. The quality of the image can be limited, and its diagnostic value is heavily dependent on operator skill. Our objective was to determine whether a standardized review process improved image quality and reduced incidence of nondiagnostic or insufficient imaging by 10% over a 6-month period.

Study Design: Between July 1, 2021, and March 31, 2022, we evaluated 1106 trauma activations at our level II trauma center. Two exams per practitioner per month were reviewed by an emergency medicine trained traumatologist with specialized training in point-of-care ultrasound and board certification in echocardiography. Priority was given to exams on patients with known injuries identified on other studies. If there were no exams that matched these criteria, random exams were selected. Images were reviewed for image quality, diagnostic accuracy, and labeling with counseling given to the provider if indicated. Categorical variables were compared using chi squared analysis, while continuous non-normally distributed variables were compared using the Mann-Whitney U test.

Results: A total of 305 FAST exams were reviewed (186 pre-intervention and 119 during intervention). Image quality improved from 46.3% (n = 31/65) to 79.0% (n = 94/119) ( P < .01) with need for counseling falling from 63.1% (n = 41/65) pre-QI to 42.0% (n = 50/119) post-QI ( P < .01). Incidence of detectable injury, BMI, ISS, and AIS body regions were consistent across the study period. This was seen in both the geriatric and non-geriatric cohorts despite a significant increase in ISS in the post-intervention geriatric patients.

Discussion: A FAST review program is associated with improvement in image quality and decreased need for counseling of trauma providers.
A Novel Common Canister Protocol for Albuterol Sulfate Metered Dose Inhalers: Conservation Strategy and Clinical Outcomes Amid COVID-19 Pandemic
Authors: Tsai Mei , Suggett Jason , Co Anthony , Ginder Tammy
Published: May 2024

The COVID-19 pandemic led to unprecedented shortages of albuterol sulfate metered dose inhalers (MDIs) utilized in the supportive management of respiratory symptoms in patients with SARS-CoV-2 infections. The risk of generating infective aerosols in nebulized treatments increased the demand for metered dose delivery, leading to a worldwide shortage of albuterol sulfate MDIs. Previous common canister protocols involve the recycling and cleaning of canisters for multiple patient use, however have not undergone quality control studies on viral cross-contamination. Torrance Memorial Medical Center utilized an off-label method of common canister administration through spacer devices, forgoing the need for sterilization while conserving albuterol sulfate during a public health emergency. A retrospective review of this emergency department protocol was conducted on 329 patients receiving this novel albuterol sulfate common canister method over a 10-month period between 3/23/2020 to 1/23/2021. Results showed 265 patients (80.5%) had improved aeration determined by breath sounds evaluation by the respiratory therapist and patient interview. Purchasing records reviewed since 3/1/2020 show purchases were sufficient to sustain albuterol sulfate MDI supply so that no treatments were delayed omitted during the 10-month evaluation period. This novel approach to common canister delivery offers a promising measure to conserve a vital inhaled medication during a public health emergency and could serve as a basis for future development of conservation and quality control studies.
Financial Inclusion—A Study of Informal Workers from Delhi NCR
Authors: Gill Kawal , Arora Gurminder Kaur , Kalra Jappanjyot Kaur
Published: May 2024

Financial inclusion is a process of providing financial services to everyone at an affordable cost, particularly to weaker sections and low-income groups. The study analyses the level of awareness, usage of banking services and other financial benefits and explores the hindrances to financial inclusion faced by the informal workers in Delhi National Capital Region (NCR). An empirical survey is done, and 760 responses are evaluated to understand the level of financial inclusion using correlation, logit regression analysis, etc. Findings of the study indicate that level of financial awareness and inclusion increase with age, education and income for fixed salary workers. Major hindrances to financial inclusion are lack of savings for using financial services, lack of necessary documentation and lack of trust in the formal banking system. Therefore, the government needs to make more efforts to reach out to the urban poor and informal workers for all-around inclusiveness.

JEL Codes: D14, E26, G2, J46, O1
Evaluation of Mpox Exposures and Outcomes in Workplaces, 6 Jurisdictions, June 1–August 31, 2022
Authors: de Perio Marie A. , Horter Libby , Still William , Meh Ie , Persson Nancy , Berns Abby L. , Salinas Andrea , Murphy Katherine , Lafferty Allison G. , Daltry Daniel , Mackey Skyler , Sockwell Denise C. , Adams Jeremy , Rivas Jenniffer , Somerville Nicholas J. , Valencia Diana
Published: May 2024

Objectives:

The risk for mpox virus (MPXV) transmission in most workplaces has not been thoroughly assessed in the context of the 2022 global mpox outbreak. Our objectives were to describe mpox case patients who worked while infectious and the subsequent workplace contact tracing efforts, risk assessments, and outcomes.

Methods:

The Centers for Disease Control and Prevention requested information from health departments in the United States in September 2022 to identify people with confirmed or probable mpox who worked outside the home while infectious, either before or after diagnosis, from June 1 through August 31, 2022. We collected and summarized data on demographic, clinical, and workplace characteristics of case patients and workplace contact investigations. We stratified data by industry and occupation categories.

Results:

In total, 102 case patients were reported by 6 jurisdictions. The most common industries were accommodation and food services (19.8%) and professional business, management, and technical services (17.0%). Contact investigations identified 178 total contacts; 54 cases (52.9%) had no contacts identified. Of 178 contacts, 54 (30.3%) were recommended to receive postexposure prophylaxis (PEP) and 18 (10.1%) received PEP. None of the contacts developed a rash or were tested for orthopox or mpox, and none were reported to have confirmed or probable mpox.

Conclusion:

Data from 6 jurisdictions suggest that the risk of MPXV transmission from workers to others in workplace settings in many industries is low. These findings might support future updates to exposure risk classifications and work activity recommendations for patients. These findings also demonstrate the importance of collecting and analyzing occupation and industry data in case reports to better understand risks in workplaces.
Do bilateral investment treaties help post-coup countries attract foreign investment?
Authors: Chen Jia , Xin Ge , Ye Fangjin
Published: May 2024

Studies of international investment treaties have debated whether these agreements independently increase foreign investment flows. This article contributes to the debate by contextualizing the impact of bilateral investment treaties on post-coup domestic political environments. We argue that these treaties enable capital-receiving countries to live up to their commitments of investment protection and promote foreign investment when signatories’ capacity for investor protection has been compromised by the political turmoil of coup events. Using a sample that covers 81 countries between 1970 and 2017, we find that bilateral investment treaties are positively associated with foreign investment in post-coup countries, and that this association is strongest in the immediate years following the coup and attenuates gradually over time. This finding potentially lends support to theorizations of bilateral investment treaties as substitutes, rather than complements, to domestic institutions in fostering investment activities.
Singlet oxygen production of Zn-Ag-In-S quantum dots for photodynamic treatment of cancer cells and bacteria
Authors: Sheng Yang , Qing Danni , Li Naijun , Zhang Peng , Sun Yixin , Zhang Rong
Published: May 2024

Zn-Ag-In-S (ZAIS) quantum dots (QDs) were synthesized with various Ag-to-In ratios and used as novel photosensitizers for photodynamic therapy (PDT) on cancer cell inhibition and bacterial sterilization, and their structural, optical, and photodynamic properties were investigated. The alloyed QDs displayed a photoluminescence quantum yield of 72% with a long fluorescence lifetime of 5.3 μs when the Ag-to-In ratio was 1:3, suggesting a good opportunity as a dual functional platform for fluorescence imaging and PDT. The ZAIS QDs were then coated with amphiphilic brush copolymer poly(maleic anhydride-alt-1-octadecene) (PMAO) before application. The 1O2 quantum yield of the ZAIS/PMAO was measured to be 8%, which was higher than previously reported CdSe QDs and comparable to some organic photosensitizers. Moreover, the ZAIS QDs showed excellent stability in aqueous and biological media, unlike organic photosensitizers that tend to degrade over time. The in vitro PDT against human melanoma cell line (A2058) and Staphylococcus aureus shows about 30% inhibition rate upon 20 min light irradiation. Cell staining images clearly demonstrated that co-treatment with ZAIS QDs and light irradiation effectively killed A2058 cells, demonstrating the potential of ZAIS QDs as novel and versatile photosensitizers for PDT in cancer and bacterial treatment, and provides useful information for future designing of QD-based photosensitizers.
Association of c.+677 C>T (rs1801133) and c.+1298 A>C (rs1801131) MTHFR genetic variants with cardiometabolic and disease risk in systemic lupus erythematosus patients: A cross-sectional study
Authors: Pesqueda-Cendejas Karen , Parra-Rojas Isela , Campos-López Bertha , Mora-García Paulina E. , Ruiz-Ballesteros Adolfo I. , Rivera-Escoto Melissa , Cerpa-Cruz Sergio , De la Cruz-Mosso Ulises
Published: May 2024

Systemic lupus erythematosus (SLE) patients present a high prevalence of cardiometabolic risk, associated with worse clinical manifestations and mortality. Folate, an essential micronutrient that participates in vital immune cellular functions, could positively affect the cardiometabolic and disease risk in SLE, through the methylenetetrahydrofolate reductase (MTHFR) enzyme, which participates in the folate metabolism, where single nucleotide variants (SNVs) have been described as a potential genetic risk factor for SLE. The aim of this study was to determine the association of the c.+677 C>T (rs1801133) and c.+1298 A>C (rs1801131) MTHFR genetic variants with cardiometabolic risk and clinical disease variables in SLE patients. A case-control study was conducted on 394 unrelated Mexican-mestizo women: 199 with SLE according to the 1997 SLE-ACR criteria and 196 control subjects (CS). Folic acid and homocysteine levels were evaluated by immunoassays. Genotyping of MTHFR genetic variants was carried out by allelic discrimination. No significant differences were found for folic acid ( p = .15) and homocysteine serum levels ( p = .59) between groups. According to the CC c.+677 MTHFR genotype, this was associated with low cardiovascular disease (CVD) risk by the Castelli index (OR = 0.42; p = .03) in SLE patients. The TC (OR = 1.3; p = .03) and the TA (OR = 1.6; p < .01) haplotypes from c.+677 C>T plus c.+1298 MTHFR were associated with SLE risk, while the CC MTHFR haplotype (OR = 0.5; p = .01) was found as a non-risk factor for the disease. In conclusion, the TC and the TA MTHFR haplotypes are associated with disease risk; meanwhile, the CC c.+677 MTHFR genotype confers lower cardiometabolic risk in Mexican-mestizo SLE patients.
Are plain language summaries more readable than scientific abstracts? Evidence from six biomedical and life sciences journals
Authors: Wen Ju , Yi Lan
Published: May 2024

In recent decades, members of the general public have become increasingly reliant on findings of scientific studies for decision-making. However, scientific writing usually features a heavy use of technical language, which may pose challenges for people outside of the scientific community. To alleviate this issue, plain language summaries were introduced to provide a brief summary of scientific papers in clear and accessible language. Despite increasing attention paid to the research of plain language summaries, little is known about whether these summaries are readable for the intended audiences. Based on a large corpus sampled from six biomedical and life sciences journals, the present study examined the readability and jargon use of plain language summaries and scientific abstracts on a technical level. It was found that (1) plain language summaries were more readable than scientific abstracts, (2) the reading grade levels of plain language summaries were moderately correlated with that of scientific abstracts, (3) researchers used less jargon in plain language summaries than in scientific abstracts, and (4) the readability of and the jargon use in both plain language summaries and scientific abstracts exceeded the recommended threshold for the general public. The findings were discussed with possible explanations. Implications for academic writing and scientific communication were offered.
Embodiment of Pharmacist Intervention in Palliative Care and Augmentation of a Curriculum for its Assessment
Authors: Thomas Ann Lithia , Nasouha Asiya , Anil Aswanth , Chandrasekhar Dilip , Palasseri Pallavi
Published: May 2024

Background

Palliative care is the care of patients who have progressive, life-threatening illnesses and who are facing death in the foreseeable future. Since there is a growing need for pharmacist’s intervention in palliative care and there is a gap in the education of palliative care for pharmacy students, this study aims to identify roles and services that have to be performed by palliative care pharmacists in medication-related areas and also to formulate an add-on course to train pharmacy graduates.

Materials and Methods

A prospective interventional study was done in the palliative care centre in Perinthalmanna, Kerala, India. Relevant data were pooled and analysed for drug-related problems. Necessary interventions were made. Results were interpreted and an add-on course for the training of pharmacy graduates was formulated.

Results

A total of 88 patients were included in the study. The most prevalent conditions in our palliative setting were kidney disease, liver disease, cancer and stroke. Notably, 38 and 10 cases were found to have drug interactions and drug duplications, respectively. Four patients required dosage adjustments. Fifty cases involved pharmacist intervention which improved the outcome by 80%. At the end of the study, a curriculum was formulated to implement a 3-month add-on course entitled ‘PALLIATIVE PHARMACY’ under the guidance of an Expert committee for training pharmacists and pharmacy students.

Conclusion

The study identified that there are various roles a pharmacist must undertake in a palliative setup. The involvement of pharmacists in patients’ treatment helps to prevent drug-related problems to a greater extent. The addition of an integrated course for the management of palliative care patients will help to improve the learning as well as practical skills of pharmacists. Incorporating basic and clinical sciences in the therapeutic course is an effective learning plan.
Human Papilloma Virus Infection and Gene Subtypes Analysis in Women Undergoing Physical Examinations: A 2015-2020 Study in Wenzhou, China
Authors: Gao Yang , Zhang Mengqi , Zheng Yuanyuan , Huang Hong , Xie Hongli
Published: May 2024

Background

Persistent infection with high-risk human papillomavirus (HPV) is closely related to cervical cancer. The epidemiologic characteristics of cervical HPV have regional differences. Therefore, it is necessary to develop the most favorable policies according to the actual situation of each region to prevent and reduce the prevalence of cervical cancer. This retrospective cross-sectional study investigated the prevalence, gene subtypes, and temporal trends of HPV in women undergoing physical examination in Wenzhou, to provide a decision-making basis for further prevention and control of HPV.

Methods

A total of 31 131 cervical exfoliated cell specimens obtained from physical examinations in Wenzhou, a coastal city of China, from 2015 to 2020 were collected. The age distribution was analyzed using the chi-squared test, and the time change trend was analyzed using the Mann–Kendall trend test. On this basis, the distribution characteristics of the HPV subtypes were analyzed.

Results

The total prevalence rate was 9.55%, and the prevalence rate in different age groups ranged from 7.77% to 14.16%. The prevalence rate in different years was 8.84%-11.83%. The prevalence rate was bimodal; it was highest in the group 25 years old, followed by the group >61 years old. The top five high-risk gene subtypes were HPV52, HPV58, HPV53, HPV16, and HPV39, whereas the low-risk subtypes were HPV61, HPV81, HPV44, HPV43, and HPV55. Of all the positive samples, 76.03% were infected with a high-risk subtype.

Conclusion

Most female HPV patients in Wenzhou are infected with high-risk gene subtypes. Therefore, physical examination and screening for HPV should be further strengthened, and the corresponding vaccination policy should focus on high-risk gene subtypes.
Exploring Risk Factors for Lower Extremity Deep Vein Thrombosis Patients with Co-existing Pulmonary Embolism Based on Multiple Logistic Regression Model
Authors: Zu Jiahong , Yang Tao
Published: May 2024

Valuable data on deep vein thrombosis (DVT) patients with coexisting pulmonary embolism (PE) is scarce. This study aimed to identify risk factors associated with these patients and develop logistic regression models to select high-risk DVT patients with coexisting PE. We retrospectively collected data on 150 DVT patients between July 15, 2022, and June 15, 2023, dividing them into groups based on the presence of coexisting PE. Univariate and multivariate logistic regression analyses were performed to identify significant risk factors and construct predictive models. Discrimination and calibration statistics evaluated the validation and accuracy of the developed models. Of the 130 patients analyzed, 40 (30.77%) had coexisting PE. Univariate analysis revealed four significant predictors of DVT patients with coexisting PE: sex (OR 3.83, 95% CI: [1.76; 8.59], P = 0.001), body mass index (BMI) (OR 1.50, 95% CI: [1.28; 1.75], P < 0.001), chronic disease (OR 5.15, 95% CI: [2.32; 11.8], P < 0.001), and high-density lipoprotein (HDL) (OR 0.03, 95% CI: [0.01; 0.20], P < 0.001). Additionally, BMI > 24 kg/m2 (OR 9.70, 95% CI: [2.70; 67.5], P < 0.001) and BMI > 28 kg/m2 (OR 4.80, 95% CI: [2.15; 11.0], P < 0.001) were associated with concurrent PE. Three multiple regression models were constructed, with areas under the receiver-operating characteristic curves of 0.925 (95% CI: [0.882; 0.968]), 0.908 (95% CI: [0.859; 0.957]), and 0.890 (95% CI: [0.836; 0.944]), respectively. Sex, BMI, chronic disease, and HDL levels are significant predictors of DVT patients with coexisting PE.
Racial and Ethnic Composition of Departments of Health Policy & Management and Health Education & Behavioral Sciences
Authors: Bather Jemar R. , Furr-Holden Debra , Burke Emily M. , Plepys Christine M. , Gilbert Keon L. , Goodman Melody S.
Published: May 2024

The diversity of racial/ethnic representation in the health services and policy research (HSPR) workforce plays a crucial role in addressing the health needs of underserved populations. We assessed changes (between 2012 and 2022) in the racial/ethnic composition of students and faculty from departments of Health Policy & Management (HPM) and Health Education & Behavioral Sciences (HEBS) among the Association of Schools and Programs of Public Health member institutions. We analyzed annual data from over 40 institutions that reported student and faculty data in 2012 and 2022 within each department. Racial/ethnic populations included American Indian/Alaska Native (AI/AN), Asian, Hispanic, Native Hawaiian/Pacific Islander (NH/PI), Black, White, Unknown, and Multiracial. We conducted analyses by department and examined racial/ethnic composition by student status, degree level, faculty rank, and tenure status. We found statistically significant increases in Black assistant professors (HPM and HEBS) and tenured faculty (HPM), Hispanic graduates and tenure-track faculty (HPM), Asian professors (HPM: full and tenured, HEBS: associate and tenured), and Multiracial students and graduates (HPM and HEBS). Statistically significant decreases were observed in White professors (HPM: assistant and full, HEBS: all ranks) and tenure-track faculty (HPM and HEBS), AI/AN associate professors and tenured faculty (HEBS), Hispanic associate professors (HPM), Asian assistant professors (HEBS), and NH/PI students (HPM and HEBS). Our findings highlight the importance of increasing racial/ethnic representation. Strategies to achieve this include facilitating workshops to raise awareness about the structural barriers encountered by Hispanic faculty, providing research support, evaluating promotion processes, establishing more pathway programs, and fostering interdisciplinary academic environments studying AI/AN or NH/PI populations.