bluuebunny/crossref_metadata_2025 huggingface dataset:
Thực trạng tự kỳ thị của người bệnh HIV/AIDS điều trị ngoại trú tại bệnh viện đa khoa huyện Mường La, tỉnh Sơn La năm 2019 và một số yếu tố liên quan
Authors: Nguyễn Thị Huyền Trang , Sa Phương Băng , Sa Trọng Kiên , Quảng Văn An , Nguyễn Thị Bình An
Published: October 2021

*Thông tin chung:Tình trạng tự kỳ thị của người nhiễm HIV/AIDS là một trong những rào cản quan trọng hàng đầu trong việc phòng ngừa và điều trị HIV.

*Phương pháp:Nghiên cứu mô tả cắt ngang về tình trạng tự kì thị của 211 đối tượng người bệnh điều trị ARV từ 3 tháng trở lên tại bệnh viên đa khoa huyện Mường La, tỉnh Sơn La năm 2019.

*Kết quả:Có 76,3% đối tượng tự kì thị với tình trạng HIV của mình, trong đó phần lớn đối tượng cảm thấy bị người khác xét đoán, kì thị 67,3%; 21,3% cảm thấy thất vọng xấu hổ, 4,7% cảm thấy có lỗi và tự đổ lỗi cho bản thân. Phân tích mô hình hồi quy logistic đa biến cho thấy khả năng tự kì thị cao hơn ở đối tượng là nữ giới OR=4,47 (95%CI: 1,90-10,05); không chia sẻ tình trạng sức khoẻ với họ hàng OR=3,02 (95%CI: 1,43-6,39); không chia sẻ tình trạng sức khoẻ với bạn bè OR=3,63 (95%CI: 1,01-13,03), mối liên quan có ý nghĩa thống kê với p<0,05. 

*Kết luận:Tình trạng tự kì thị trong nghiên cứu khá cao, một số đặc điểm liên quan tình trạng chia sẻ tình trạng sức khỏe liên quan đến tình trạng tự kì thị của đối tượng.
A QUALITATIVE STUDY OF UNINTENTIONAL PROCRASTINATION, DEPRESSION AND BODY IMAGE IN INDIA
Authors: Karthikeyan Ranjini , Bhaumik Amiya
Published: October 2021

Procrastination can lead to depression and depression can result in procrastination. Depression is a withdrawal from normal psychological functioning. The way you perceive about your body is your cognitive body image. This can lead to excessive concern with body shape and weight. Behaviors in which you relate as a result of your body image encompass your behavioral body image. Depressed people interact less with the world than they did when they were functioning in a healthy way of thinking and behaving. Depressed people withdraw from the world because they may find human interaction too stressful and threatening. Anotable symptom in depression is a lack of drive to initiate or perform any task. This study is interview research aims to assess the amount of unintentional procrastination in body image concerned depressed patients in efforts to justify the symptoms. The sample size consists of 30 depressed patients‟ age ranging from 21-60 which includes both men and women, identified with symptoms of depression due to body image and patients who have been treated with antidepressants for 3months-6years. The Unintentional Procrastination Scale by Bruce A.Fernie (2016) is used in this study. Results revealed from the test conducted, Out of 30 depressed patients, above 25% to 40% of the patients responded with moderate agreement. Most of them face disturbances in their occupational lives, because of the unintentional procrastination that bothers them. Keywords: Procrastination, Depression, Body Image
Fractional electrolyte excretion and osmolality in the early diagnosis of acute kidney injury in cats with urethral obstruction
Authors: Xavier Júnior Francisco Antônio Félix , Morais Glayciane Bezerra de , Pereira Thyago Habner de Souza , Carvalho Isadora Oliveira de , Silva Fernanda Menezes de Oliveira e , Sampaio Tiago Lima , Martins Alice Maria Costa , Monteiro Helena Serra Azul , Silva Isaac Neto Goes da , Evangelista Janaina Serra Azul Monteiro
Published: October 2021

Acute Kidney Injury (AKI) can be defined as a spectrum of diseases associated with a sudden onset of a renal failure status, the feline patient has azotemia, the disorder in fractional electrolyte excretion (FE), and shedding of epithelial cells from renal tubular segments observed in the urinary sediment. Thus, the objective of the present study was to evaluate the FE, plasma and urinary osmolality, and urinary specific gravity (USG) in cats that spontaneously developed AKI due to urethral obstruction (UO) and healthy cats. Blood and urine samples were collected from a group of 20 cats diagnosed with AKI secondary to urethral obstruction (GAKI; n=20) and clinically healthy cats (GC; n=15). The serum creatinine (sCre) and urinary creatinine (uCre), were measured by spectrophotometry, serum and urinary analyzes of sodium, potassium and chloride by ion selective electrode device and serum and urinary osmolarity by osmometer. The GAKI results were statistically compared with those of the CG using Student's t tests to assess normal data, while the Maan-Whitney test was used for non-normal data. A significant increase in the sCr, sK, FENa, FECl and RFI parameters of the GAKI cats when compared to the GC (p < 0.05). The sCl, USG, uCr, uK and uOSM parameters decreased significantly when compared between the two groups. Thus, given the established methodology and the results found, it is possible to infer that an increase in EFNa, EFCl in addition to the RFI and a decrease in USG and uOSM were associated with cats with AKI and can serve as markers of kidney damage, as well as monitoring the prognosis.
ENFERMAGEM NA PREVENÇÃO E CONTROLE DE INFECÇÃO DE NEONATOS: REVISÃO INTEGRATIVA
Authors: Nascimento de Albuquerque Roberto , De Andrade Bezerra Caroline , Caetano Martins Thaís Kelly , Santos Silva Carla Andréia , Da Silva Ramos Pedro Henrique
Published: October 2021

Mundialmente, o número de mortes entre neonatos foi de 2,4 milhões em 2019, ocorrendo aproximadamente 7.000 mortes por dia. Neste mesmo ano, o Brasil apresentou um registro de 24.504 óbitos de neonatos por causas evitáveis. Os enfermeiros desempenham importantes ações no cuidado de neonatos nascidos em qualquer condição gestacional, sejam eles saudáveis ou com infecção congênita ou adquirida. Nesse contexto, o objetivo deste estudo foi identificar ações de saúde desenvolvidas pela equipe de enfermagem na prevenção e controle de infecção de neonatos. Tratou-se de uma revisão integrativa de literatura nas bases de dados eletrônicas LILACS, BDENF e MEDLINE, com artigos publicados entre 2011 a 2021, disponíveis na íntegra, em português, inglês e espanhol.  Inicialmente foram encontrados 386. Após a aplicação dos critérios de inclusão e exclusão, foram selecionados 15 artigos para comporem a discussão deste artigo. Importantes ações da equipe de enfermagem foram demonstradas, destacando-se a lavagem das mãos, a utilização de proteção pessoal, os cuidados com a pele e para a implantação de cateteres centrais, orientações relacionadas à amamentação e os cuidados envolvendo a participação dos pais. Conclui-se que os enfermeiros neonatais realizam intervenções de alta complexidade, além de atuar na prevenção e promoção à saúde. Trabalhos educativos continuados para seu aperfeiçoamento é importante visando atualizar e melhorar a qualidade e segurança do cuidado de enfermagem.
TRASMISSÃO DE ZIKA VÍRUS DURANTE A GESTAÇÃO EM RECÉM-NASCIDOS E MICROCEFALIA: UMA REVISÃO NARRATIVA
Authors: Souza Ana Caroline Nogueira Moreira , Oliveira Jessyca Zanella Ferreira de , Moreira Gabriel Spechoto , Perillo Ana Luísa
Published: October 2021

O Brasil foi o primeiro país a identificar uma possível relação entre a infecção pelo vírus Zika na gestação e a ocorrência de microcefalia em recém-nascidos (RN). A partir do estabelecimento de uma força tarefa nacional, dentre os primeiros 35 casos de RN com microcefalia notificados em oito estados do país (Agosto e Outubro de 2015), todas as mães residiam ou visitaram áreas infectadas pelo vírus durante a gestação. Esta pesquisa teve por objetivo buscar evidências na literatura, acerca dos achados sobre a relação entre a infecção pelo vírus Zika durante a gestação e as consequências neonatais, por meio de uma revisão narrativa. Para a construção da presente revisão, foi determinado algumas etapas: definição e refinamento do tema de pesquisa; determinação dos critérios de inclusão e exclusão dos artigos pesquisados, discussão dos resultados obtidos e descrição da síntese do conhecimento obtido. As plataformas escolhidas foram: Scielo, PubMed e Web of Science, as palavras-chave utilizadas foram “child” e “Zika Vírus”. Como critério de inclusão foram obtidos artigos publicados no período de 2015 a 2020, nos idiomas português e/ou inglês. Foram excluídos artigos publicados fora dos padrões determinados acima. As anomalias no (Sistema Nervoso Central) SNC dos pacientes acometidos com ZV revelam características especificas para crianças, durante o seu desenvolvimento. Estas anomalias podem ser representadas como convulsões, disfagia, irritabilidade, hipertonia, hiperreflexia e reflexos arcaicos aumentados. Apesar de muitos estudos acerca do ZV e a associação da microcefalia, através a transmissão via transplacentária, não é possível confirmar com precisão o desencadeamento por ambos. Ainda não se sabe ao certo o mecanismo que leva ao surgimento da microcefalia por meio da infecção do Zika vírus. O que tudo indica é que a infecção e a inflamação geradas pelo micro-organismo causem danos na estrutura e replicação das células nervosas.
Human Resource Management Practices and Employee Performance in Canon Chemicals Limited in Kenya
Authors:   Kenyatta University, Muchiri Nyaguthii Roselyn , Muli Vika Dr. Jedidah ,   Kenyatta University
Published: October 2021

Although several studies have been done on the notion and context of Human Resource Management Practices (HRMPs) and their influence on employee performance in numerous organizations, none has been done within the cosmetic industry in Kenya. Therefore, there was a need for a study to be carried out concentrating on Kenya's cosmetic industry on what HRMPs impact on employee performance. The study was conducted at Canon Chemicals Limited in Mavoko Sub County, Kenya. The specific objectives were to determine the effects of compensation and workers participation on employee performance. The study utilized descriptive research design. A sample of 40 participants was selected using census approach since the population at Canon Chemicals Limited was small. A structured questionnaire was used to collect data from the study participants and all the distributed questionnaires were duly filled and returned. Descriptive statistics used were frequencies and percentage distribution, while inferential analysis were correlations and regression. The findings of the study suggest a moderate relationship between HRMPs and overall employee performance. Contrary to expected results, regression analysis did not show a significant relationship between HRMPs under consideration and employee performance. Therefore, HRMPs should not be generalized to enhance employee performance; rather, other confounding factors that are out of scope in this current study may play a significant role in overall employee performance. The result of this study is an indication that Canon Chemicals Limited should improve on all the aspects of human resource management practices that include employee compensation and employee participation to spur overall employee performance. The organization needs to carry out regular surveys and have merit employee motivation and embrace a human resource management practices policy. Keywords: Human Resource Management Practices (HRMPs), Performance Management.
DILEMA PELAKU PERKAWINAN LEVIRAT
Authors: Ivamut Endemina
Published: October 2021

Dilema pelaku perkawinan Levirat adalah perkawinan yang di lakukan oleh saudara-saudara atau kerabat yang masih memiliki ikatan hubungan kekeluargaan, yang dilakukan dengan tujuan menegahkan nama orang yang meninggal tanpa memiliki keturunan. Tetapi yang sering terjadi adalah pihak yang diharuskan melakukam perkawinan ipar ini menolak karena tidak ingin merusak hak-haknya. Itulah sebabnya dasar dari perkawinan Levirat ini adalah KASIH. Didalam KASIH tidak ada yang namanya keterpaksaan tetapi kasih itu dilakukan dengan sabar dan sukarela, intinya: dasar dari penebusan adalah kasih.
PRINSIP-PRINSIP MENDIDIK ANAK USIA 0-12 TAHUN BERDASARKAN ULANGAN 6:1-9
Authors: Dowansiba Agustina
Published: October 2021

Tumbuh kembang anak ditentukan oleh cara mendidik anak yang tepat, yang dilakukan oleh orang tua maupun guru berdasarkan pertumbuhan usia yang sedang dialaminya. Mendidik memiliki arti yang luas diantaranya proses mengajar, membimbing mengarahakan memberi motivasi atau dorongan, menasehati, mendisiplinkan, menuntun dan memberi petunjuk untuk mencapai suatu tujuan yang memiliki niliai-nilai yaitu tercapainya perubahan sikap dari seseorang yang dididik. Prinsip-prinsip anak usia 0-12 tahun menurut Ulangan 6;1-9 dan implementasi bagai orang tua suku Arfak merupakan topik yang sangat penting untuk dibahas berhubungan dengan cara mendidik anak dalam lingkup suku Arfak. Mendidik anak usia 0-12 tahun menurut ulangan 6:1-9 dipandang sebagai pola pendidikan berdasarkan Alkitab. Oleh karena itu pembahasan ini sangat relevan bagi semua suku, bangsa dan bahasa tidak terkecuali suku Arfak. Begitu banyak keluarga yang tidak harmonis, dimana kasih sanyang ditutupi oleh kemarahan dan kejengkelan. Masih banyak keluarga yang dalam keseharian hidupnya selalu diliputih oleh perselisihan, suasana muram, kekecewaan, timbul percocokan, dan rasa dendam di antara anggota keluarga. Sesungguhnya, kebahagiaan paling besar dan kepuasan paling mendalam serta ketenangan batin paling dalam, semunya berasal dari kehidupan keluarga yang penuh kasih sayan dan harmonis.
Dialling up Learning: Testing the Impact of Delivering Educational Content via IVR to Students and Teachers in Ghana
Authors: Afoakwah Edmund , Carballo Francisco , Caro Alex , D’Cunha Samantha , Dobrowolski Stephanie , Fallon Alexandra
Published: October 2021

An output of the EdTech Hub, https://edtechhub.org
RECENT ADVANCEMENTS AND DEVELOPMENTS IN FLOATING DRUG DELIVERY SYSTEM - AN APPROACH FOR GASTRO RETENTION
Authors:   Department of Pharmaceutics KLEUs College of Pharmacy Belgaum- 590010, Karnataka, India., Dandagi P.M. , Dhople N.G. , Dessai G.A , Gadad A.P.
Published: October 2021

Technological attempts have been made in the research and development of rate controlled oral drugdelivery systems to overcome physiological adversities, such as short gastric residence times (GRT) andunpredictable gastric emptying times (GET). Several approaches are currently utilized in the prolongationof the GRT, including floating drug delivery systems (FDDS), swelling and expanding systems, polymericbioadhesive systems, high density systems, modified shape systems and other delayed gastric emptyingdevices. In this review, current & recent developments of stomach specific FDDS are discussed. Therecent developments of FDDS including the physiological and formulation variables affecting gastricretention, approaches to design floating systems, and their classification and formulation aspects arecovered in detail. Although tremendous advances have been seen in oral controlled drug delivery systemin the last two decades, this system has had limited success in the case of drugs with a poor absorptionwindow throughout the GIT (Gastro Intestinal Tract).
RP-HPLC METHOD DEVELOPMENT FOR THE ASSAY OF AMPHOTERICIN B
Authors:   Vignan Institute of Pharmaceutical Sciences Deshmukhi, Nalgonda, Andhra Pradesh - 508284, India., Mohankrishna L , Reddy P. J. , Reddy. B. P , Navya P.
Published: October 2021

A sensitive and precise HPLC procedure has been developed for the assay of amphotericin B in bulk samples and pharmaceutical formulations by using a C18 column [Kromosil, C18, (5 µm, 4.6mm x 250 mm; Make. Waters)], and mobile phase combination is 1% formic acid in water and acetonitrile in ratio of 45:55 V/V. The procedure has been validated as per the ICH guidelines. The λmax of detection was fixed at 407 nm, so that there was less interference from mobile phase with highest sensitivity according to UV analysis. Calibration plots were linear in the range of 10-100 µg/mL and the LOD and LOQ were 0.02 µg/mL and 0.06 µg/mL respectively. The high recovery and low relative standard deviation confirm the suitability of the method for routine quality control determination of amphotericin B in different formulations.
INVESTIGATION OF SOLUBILITY ENHANCEMENT OF PRASUGREL HYDROCHLORIDE: NANOSUSPENSIONS AND CYCLODEXTRIN INCLUSION COMPLEXES
Authors:   Mother Teresa College of Pharmacy NFC Nagar, RR Dist, 501301, Andhra Pradesh, India., Devara R. K , Reddipogu P. , Kumar S , Rambabu B. , Jithan A. , Habibuddin M.
Published: October 2021

The objective of this study was to investigate nanosuspensions, hydroxypropyl-β-cyclodextrin (HPβCD) complexes and SLS powders for enhancing the solubility and dissolution rate of Prasugrel HCl (PHCl) so as to reduce the fluctuations in its oral bioavailability. PHCl nanosuspensions were prepared using evaporative precipitation method. HPβCD inclusion complexes of PHCl were prepared using physical mixture, co-evaporation and kneading methods. Powders of the pure drug with different SLS amounts were prepared. The formulations were characterized using techniques such as powder x-ray diffractometry, scanning electron microscopy, in vitro dissolution and in vivo absorption in rats. To further aid in the betterment of development of nevirapine nanosuspension, in vitro in vivo correlation (IVIVC) was established using deconvolution technique. Nanosuspensions and HPβCD inclusion complexes of PHCl were successfully prepared. The dissolution rate and oral absorption of PHCl in the form of nanosuspensions was significantly higher than that of HPβCD complexes, SLS powders as well as pure drug. All the techniques investigated in this study can be used to enhance dissolution rate and oral absorption of prasugrel HCl and thus can reduce the fluctuations in its oral bioavailability. Nanosuspensions demonstrated to be better and superior technique when compared to other techniques investigated in enhancing oral bioavailability of PHCl. IVIVC that could aid in further formulation development of PHCl nanosuspension was successfully developed using a deconvolution approach.
ISOLATION AND CHARACTERIZATION OF EXOPOLYSACCHARIDES FROM LACTIC ACID BACTERIA AND ITS USE IN FORMULATION DEVELOPMENT
Authors:   Department of Pharmaceutics KLEUs College of Pharmacy Belgaum-590010, Karnataka, India, Gadad A. P. , Singh R. , Darbha N. S , Dandagi P. M.
Published: October 2021

Exopolysaccharides (EPS) are polymers that consist principally of carbohydrates and are excreted by some microorganisms onto the outside of their cell walls. Several strains of lactic acid bacteria (LAB) are able to produce EPS which can be used as natural additives to enhance the rheology and texture of novel food products. they are considered as food-grade microorganisms known as Generally Recognized as Safe (GRAS). Various milk and curd samples were screened for the isolation of lactobacilli. The colonies were subcultured in milk media (50%) maintained at 20º C for 72 hours under anaerobic conditions for the production of EPS. EPS was then isolated after ethanol precipitation. Two promising EPS were obtained from two different milk samples and named as EPS 1 and EPS 5. The two EPS were isolated showing promising results. The isolated EPS were evaluated as an excipient in the formulation development and were explored as binder in tablets. The tablets were evaluated for hardness, friability, weight uniformity, disintegration and invitro dissolution profiles. The binding property of the two EPS was investigated in diclofenac tablets formulated by wet granulation using polyvinylpyrrolidone (PVP) and gelatin. Results indicated that formulation prepared with EPS have shown good hardness and friability in tablet formulations when compared to PVP and gelatin.
EVALUATION OF ANTIARTHRITIC ACTIVITY OF YOGRAJ GUGGUL FORMULATION IN FREUNDS ADJUVANT INDUCED POLY-ARTHRITIC RAT MODEL
Authors:   Sinhgad Institute of Pharmaceutical Sciences (SIPS) Kusgaon (Bk), Off Mumbai- Pune Expressway, Lonavala, Pune 410 401, India., Kaneria M , Sharma G. , Wadekar R. R. , Pereira M. , Naik S. R
Published: October 2021

The paper discusses evaluation of antiarthritic activity of Yograj guggul formulation in freund’s adjuvant induced poly-arthritis rat model. The findings demonstrate that the treatment with Yograj guggul formulation (200, 400 mg/kg/day) for 14 days produced a significant anti-arthritic activity (decreased arthritic index), inhibited connective tissue metabolism (reduced hydroxyproline and hexosamine content of edematous tissue) and caused haematological alterations (WBC, RBC, ESR and differential cell count) occur during Freund’s adjuvant induced polyarthritis in rats. The antiarthritic effect of Yograj guggul formulation at 400 mg/kg was comparable to that of reference drug, diclofenac sodium (10 mg/kg). The antiarthritic activity observed in the present study may be attributed to the various herbs present in the formulation. It is proposed that, the Yograj guggul formulation elicited antiarthritic activity largely due to the prevention of connective tissue breakdown, decreased capillary permeability and improvement of immune system.
IN VITRO CHARACTERISTICS OF MODIFIED PULSINCAP FORMULATION WITH MESALAMINE FOR ULCERATIVE COLITIS TREATMENT
Authors:   Department of Pharmaceutics Sree Vidyanikethan College of Pharmacy A.Rangampet, Tirupati - 517102 Andhra Pradesh, India., Vadlamudi H. C , Prasanna Raju Y , Rubia Y. B , Vulava J. , Vandana K.R
Published: October 2021

The present work aims at fabricating the colon specific drug delivery of mesalamine (MES) by modified pulsincap technique and using natural polysaccharides. Mesalamine being poorly water soluble drug, solubility has been increased by solid dispersion technique using natural polymers such as guar gum (GG), hupu gum (HG) and xanthan gum (XG). Solid dispersions were prepared by kneading method at 1:1, 1:2 and 1:3 weight ratios (drug:polymer). The solid dispersions were characterized by FTIR, DSC studies and evaluated for practical yield, drug content. Saturation solubility, pH dependent solubility, phase solubility studies and dissolution studies were carried out. The solubility of the formulated solid dispersions was high when compared to pure drug. The order of drug release from the solid dispersions prepared by different gums are as follows GG>HG>XG and different ratio exhibited release as 1:3>1:2>1:1. The optimized solid dispersions have been exploited in the formulation of pulsincaps. Bodies were made insoluble by formaldehyde treatment. Solid dispersions of mesalamine were filled in the bodies. Guar gum (GG) was used as hydrogel plug. Sealing of body and cap was done using ethyl cellulose. Ethyl cellulose coating was employed on pulsincaps to ensure the capsule empties from the stomach intact. The pulsincaps were assessed for their dissolution profiles. Percent MES release from pulsincaps prepared with pure MES, MES-GG, MES-HG and MES-XG solid dispersions were found to be 63.22, 96.25, 94.90 and 93.05 respectively. Our studies have shown very effective and desirable mesalamine release profiles by pulsincap formulations at simulated colon pH condition, which can enable the drug delivery specifically at colon segment.
Formación de diseñadores del siglo XXI para el siglo XXI
Authors: Forero Salazar Sandra , Luna Maldonado Carlos Manuel
Published: October 2021

El presente texto hace un breve recorrido por diferentes propósitos de formación para el mundo actual, iniciando por la descripción del contexto mundial desde una mirada general hasta un panorama particular en Diseño, seguido por la descripción de los desafíos a los que la educación debe responder en tiempos de globalización. Finalmente se aborda la propuesta que desde el Programa de Diseño Industrial de la Universidad de Pamplona se ha implementado para la formación de diseñadores en el Siglo XXI para el Siglo XXI y en la cual se tiene como fundamento curricular la proyectación ambiental.
Participación, co-diseño y colaboración
Authors: Amador-Cardona Paula Camila , Navarro Peralta María Victoria , Ortegón Juan Paulo , Quintana Lemus Mauro F. , Ruíz Mary Evelyn
Published: October 2021

El Taller Interinstitucional de la Red Académica de Diseño - RAD, en funcionamiento desde 2002, se propone la evangelización en diseño frente al sector productivo. Tarea para la cual cuenta con el apoyo de la Cámara de Comercio de Bogotá y su estrategia de clusters. En la versión 33, el Taller RAD se reformula, tomando el co-diseño como método para organizar el trabajo conjunto entre profesores, estudiantes y empresarios. En esta ponencia se examinan los movimientos de participación, co-diseño y colaboración en conversación con la metodología desarrollada para el taller, compuesta por la construcción de problemas, síntesis de diseño y ciclos de prototipado; así como los resultados de esta primera versión en la que se identificaron importantes lecciones para la gestión del trabajo en el aula, la preparación de los docentes para un taller de co-diseño, la definición de los roles de los stakeholders y la propia gestión de un proyecto de colaboración entre academia y empresa. Finalmente se formulan recomendaciones para atender a los principales obstáculos encontrados en este camino de colaboración.
Diseño Gráfico
Authors: Uscátegui Mireya , Castellanos Alejandra , Lasso Juan Gabriel
Published: October 2021

La profesionalización del diseño en Colombia, como en otros países de la región, enfrenta hoy la concurrencia de múltiples requerimientos que provenientes de diversos contextos desafían el campo curricular de los programas de formación universitaria de diseñadores en los niveles de pregrado y postgrado. En tal virtud, los autores, miembros del grupo de investigación Currículo y Universidad de la Universidad de Nariño, adelantaron un proceso de investigación curricular durante el período comprendido del 2017 al 2019 orientado a la renovación del programa de diseño gráfico de esta institución cuyo resultado fue una propuesta curricular que pretende un cambio incremental (Christensen, 2013; Acaroglu, 2017) del currículo tal que a partir de su implementación vaya abriendo nuevos caminos hacia la inter y transdisciplinariedad como epistemologías que prefiguran hoy el horizonte del diseño bajo el propósito de incidir efectivamente en el entorno desde el concepto de diseño gráfico con sentido social (Hidalgo, 2013). El documento que en esta ocasión se presenta comprende el aspecto investigativo-metodológico, la propuesta propiamente dicha y una discusión derivada de las experiencias de construcción y/o renovación curricular en el campo del diseño.
ProFuture: shaping the future of microalgae proteins in Europe
Authors: Castellari Massimo
Published: October 2021

ProFuture: shaping the future of microalgae proteins in Europe
Agenda 2030 para el Desarrollo Sostenible:
Authors: De Jesús Dávila Amelisse Yamel
Published: October 2021

La situación que atraviesa Puerto Rico en los últimos años presenta grandes retos sociales, económicos y políticos a enfrentar.  Una de las tendencias para dar respuesta a estos desafíos ha sido retomar el concepto de desarrollo sostenible, incorporando una perspectiva de derechos humanos, como referente para hacer cara a las complejas problemáticas vividas cotidianamente.  Las organizaciones internacionales han apostado a la Agenda 2030 para el Desarrollo Sostenible como guía para el alcance de sociedades justas en la era de capitalismo avanzado. Esto tiene repercusiones para con el ejercicio de la profesión de trabajo social en esta coyuntura.  En este trabajo se abordan algunas de ellas. [Palabras claves: desarrollo, desarrollo sostenible, Objetivos Desarrollo Sostenible, trabajo social, derechos humanos, proyecto profesional].
costos sociales del carácter punitivo contra las drogas
Authors: Rivera Diaz Marinilda , Sanchez Leniel Arroyo
Published: October 2021

Hablar sobre el costo social que tiene el carácter punitivo contra las drogas, requiere mirar la construcción socio histórica del concepto mismo y de la persona consumidora. Pero ello, también requiere de un análisis sobre aquellos determinantes sociales, particularmente estructurales, que inciden en el consumo problemático de las drogas y en la violación a los derechos humanos de esa persona. Este artículo tiene el propósito de analizar las nociones del uso de drogas que se han gestado desde las diversas instancias de la sociedad y el estado, con mayor énfasis en la política de Guerra Contra las Drogas y el impacto que esto tiene en la persona consumidora. Además, se discutirá la desigualdad social como factor apremiante del fenómeno de las drogas, apartándonos de la mirada individualista y punitiva, al reconocer los determinantes sociales de la salud y el marco de los derechos humanos como importantes coordenadas para el tratamiento de personas con uso problemático de las drogas.
Birth Defects following Levetiracetam Use in Pregnancy – A Case Report
Authors:   Department of Pediatrics, Guru Teg Bahadur (GTB) Hospital, New Delhi, India, Pandey Mukul , Batra Prerna ,   Department of Pediatrics, Guru Teg Bahadur (GTB) Hospital, New Delhi, India
Published: October 2021

There is a lack of substantial data on the safety of Levetiracetam during pregnancy in the context of the potential teratogenic effect on the newborn. We report a probable case of levetiracetam birth defects in a newborn with multiple congenital anomalies.
Dyslipidaemia - Current and Future Treatment Paradigm
Authors:   Fortis Hospital Mohali, Punjab, India, Kochar Arun
Published: October 2021

Dyslipidaemia is one of the major risk factors for coronary vascular disorders. Dyslipidaemia prevention and management can have a great impact on cardiovascular morbidity and mortality. There are many lipid-modifying pharmacological medicines on the market, and more are being developed. New guidelines recommend aggressive lipid-lowering targets depending on the atherosclerotic cardiovascular (ASCVD) risk. Depending on the risk of these risks, new guidelines advocate aggressive lipidlowering targets. For many years, statins had been the standard care, and demonstrated to reduce the risk of cardiovascular events. Novel molecules such as PCSK9 inhibitors, selective inhibitors of microsomal triglyceride transfer protein, small interfering RNA (siRNA), and antisense oligonucleotide drugs, could be interesting new additions to effective lipid-lowering therapy, are now accessible. We look into the history, method of action, key clinical studies, and side effects of therapeutic targets for dyslipidaemia to see where they fit into the therapy armamentarium now and in the future.
Oclusão de artéria ilíaca diagnosticada por Ultrassom Point of Care
Authors: Dos Santos Souza Felipe , Machado Benincá Vitor
Published: October 2021

Objetivo: descrever uso do Ultrassom Point of Care (POCUS) para o diagnóstico rápido de oclusão de artéria ilíaca em um departamento de emergência. Relato de caso: paciente masculino, 65 anos, chega a unidade de emergência, com queixa de dor nas costas que irradiava para membro inferior direito. Comorbidades: Hipertensão Arterial Sistêmica (HAS), Diabetes Mellitus (DM) e Doença Coronariana Aguda (DAC). USG da região de ilíacas que revelou: oclusão arterial subaguda em região ilíaca direita, demonstrando ausência do fluxo. Conclusões: os sintomas apresentados em um quadro sugestivo de oclusão de artéria subaguda envolvem: dor intensa, sensação polar ou frio, parestesias ou anestesias, palidez dos membros e ausência de pulsos. Nesse caso, observa-se que a utilização do método POCUS foi fundamental no diagnóstico e manejo da emergência do paciente à beira do leito.
Colaboração institucional entre Ministério Público, Poder Judiciário e os profissionais de psicologia das políticas públicas de assistência social e de saúde
Authors: Viana Diego Mendonça
Published: October 2021

O trabalho objetiva discutir os diversos e complexos fatores que envolvem a colaboração interinstitucional entre Ministério Público (MP), Poder Judiciário (PJ) e as equipes multiprofissionais das políticas públicas de Assistência Social e de Saúde no estado do Ceará. A metodologia consistiu na análise quantitativa e qualitativa das demandas dos anos de 2013 e 2015 sobre as requisições do MP ou do PJ. Os resultados evidenciam que as requisições para as equipes de políticas públicas produzem sobrecarga de trabalho, conflitos éticos, bem como aumento das tensões entre equipes e população acompanhada. Concluiu-se que se faz necessário que o MP e o PJ formem suas equipes de apoio com profissionais peritos e assistentes técnicos, e que estes trabalhem em colaboração com os profissionais das políticas públicas, bem como se faz necessário o estabelecimento de diálogo interinstitucional para melhoria dos fluxos de colaboração.
papel dos estados-membros na melhoria da paroteção ambiental brasileira
Authors: Farias Paulo José Leite
Published: October 2021

Este artigo mostra que a federação brasileira potencializa mecanismo institucional de proteção ambiental na medida em que um estado-membro pode se constituir em bem-sucedido laboratório de proteção ambiental por meio do federalismo de cooperação, que lhe garante autonomia parcial para legislar a respeito da proteção do meio ambiente, permitindo adequação entre as normas ambientais e os diferentes biomas brasileiros. Ademais, a garantia de um piso nacional de proteção por meio das normas federais gerais garante a unidade da proteção.
estado de coisas inconstitucional da saúde e o necessário diálogo institucional entre as funções estatais
Authors: Lima Rodrigo de Luna
Published: October 2021

O presente artigo discorre sobre a possível existência do Es­tado de Coisas Inconstitucional na saúde pública do Brasil. Para tanto, apresenta o conceito de direito fundamental e o analisa sob a ótica de suas dimensões objetiva e subjetiva, discute sobre a dis­crepância entre previsão normativa e realidade fática como espécie de inconstitucionalidade, discorre sobre aspectos da titularidade do direito à saúde, apresenta o conceito e requisitos do Estado de Coisas Inconstitucional e discute a possível existência dessa inconstitucio­nalidade na saúde pública do Brasil. Por fim, pondera a necessidade dos Diálogos Institucionais com o objetivo de solucionar omissões estatais e deficiências nas políticas públicas em saúde. Para tanto, este trabalho sustenta-se numa pesquisa exploratória, utilizando-se a abordagem qualitativa para evidenciar a análise valorativa acerca do objeto de pesquisa. Para subsidiar o corpus teórico para discussão da temática, lançou-se mão da pesquisa bibliográfica, em artigos, sites jurídicos, livros e outros.
A HISTÓRIA DA DEFICIÊNCIA, A INTERNAÇÃO PSIQUIÁTRICA E A ATUAÇÃO DO MINISTÉRIO PÚBLICO EM ALGUNS CASOS PARADIGMÁTICOS
Authors: Caramuru Pessoa Auber Anna
Published: October 2021

O objetivo deste artigo é (i) traçar um panorama histórico sobre o tratamento dado a indivíduos com deficiência, utilizando Michel Foucault como referencial teórico; e (ii) por meio de metodologia exploratória e indutiva, fazer um apanhado de casos em que a discussão em torno da institucionalização psiquiátrica no Brasil ganhou espaço, verificando-se três exemplos de atuações diversas do Ministério Público, quais sejam, pela (a) elaboração de relatórios investigativos sobre a situação de pessoas em condição de internação; (b) atuação no caso Ximenes Lopes versus Brasil; e (c) elaboração de Termo de Ajuste de Conduta no município de Sorocaba (SP).
Biodiesel production from catfish (Pangasius) fat via ultrasound- assisted method
Authors: Intan Shafinaz Abd Manaf  , Mohd Hasbi Ab. Rahim  , Gaanty Pragas Maniam
Published: October 2021

This paper reports studies in ultrasound-assisted heterogeneous solid catalyzed (CaO) synthesis of biodiesel from catfish (Pangasius) fat. Ultrasonication provides a faster chemical reaction, and the rate enhancements, refereed by cavitation that causes the building- up of pressures and temperatures, as well as increased catalytic surface areas and improve mass transfer. This novel method offers significant advantages such as shorter reaction time and less energy consumption than the conventional method, efficient molar ratio of methanol to triglycerides and provides the mechanical energy for mixing. The required activation energy for initiating the transesterification reaction and so, it gives a higher yield by transesterification of oils into biodiesel. The optimized reaction conditions were as follows: methanol to oil molar ratio of 15:1; catalyst (B-CaO), 9 wt. %; reaction temperature, 65 ± 2 °C; reaction time, 1 h at a working frequency of 42 kHz and the power supply of 100W. Highest conversion of 96.4 wt. % was achieved.
Effect of salt on growth and ethanol production of ethanologenic yeasts – A preliminary investigation
Authors: Binita Dev  , Balasubramanian P  , Jayabalan R
Published: October 2021

Seawater can reduce the freshwater footprint in bioethanol industries by replacing it in several bioprocessing steps in bioethanol production. However, the yeasts must be salt tolerant and be able to produce ethanol in seawater. In the present study, the salt tolerance capacity of two ethanologenic yeasts was checked in YPD and YPX media in the presence and absence of salt by comparing their growth and fermentation ability to produce ethanol. P. stiptis NCIM 3498 performed better regarding ethanol production when compared to S. cerevisiae NCIM 3570. The presence of salt did not impact the glucose and xylose fermentation by the yeasts.
Green biomass to biogas – A study on anaerobic monodigestion of para grass
Authors: Ajcharapa Chuanchai  , Sawitree Tipnee  , Yuwalee Unpaprom  , Keng-Tung Wu
Published: October 2021

Recently, biogas production through anaerobic digestion technology has advanced massively. At the moment, caused by high energy demand and environmental concerns as the world’s population increases, the drive for anaerobic digestion processes is achievement drive within research and the industry for sustainable energy generation. The study evaluated biogas production from anaerobic mono-digestion of para grass in laboratory scale studies. In addition, improvement of the biogas yield from the grass via chemical pretreatment and leaching bed reactors was studied. Methane content of biogas was 54.36 % by mono- substrate. The results revealed that para grass can be treated anaerobically and are a good source of biogas.
Culturing of green photosynthetic microalgae (Chlorella sp.) using palm oil mill effluent (POME) for future biodiesel production
Authors: Nithin B. R.  , Prakash Bhuyar  , Marlen Trejo  , Mohd Hasbi Ab. Rahim  , Gaanty Pragas Maniam  , Natanamurugaraj Govindan
Published: October 2021

Nowadays, the water pollution is leading issue due to palm oil mill effluent (POME), waste from palm oil production is a big problem to Malaysia which is largest palm oil producers. POME containing large amount of chemical oxygen demand (COD) which can cause severe pollution to the environment especially water. This present study designed for culturing green algae (Chlorella sp.) isolated from Pantai Balok, Kuantan which is most common microalgae with palm oil mill effluent (POME). Chlorella sp. was cultured using BG-11 medium with the addition of POME as experiment and without POME as control. The POME responsible for the growth of green algae is studied by measurement of the growth rate, total cell count and chemical oxygen demand (COD) for both conditions. The composition for control and experiment is also measured and determined by using Gas Chromatography Mass Spectrometry (GCMS). From the results, it is observed that the total cell count and growth rate of Chlorella sp. greater in presence of POME since the green microalgae absorbs the essential nutrients from the POME as their nutrients. GCMS revealed that the difference in composition for both the conditions. Results concluded that several COD also vigorously deplete with the help of green algae digestion. Cultivation of Chlorella sp. in POME will help in future water pollution treatment.
Sea grape (Caulerpa lentillifera) cultivation in artificial seawater closed system
Authors: Udomluk Sompong  , Jirayu Mingkaew  , Doungporn Amornlerdpison  , Kriangsak Mengumphan
Published: October 2021

In the present study, the daily relative growth rates of the green macroalga (sea grape, Caulerpa lentillifera) in artificial seawater closed system with cement ponds was evaluated. Cultivation in artificial seawater was investigated for the combined impact of three significant aspects: algal productivity, water quality and nutritional value. Sea grape was cultured for 30 days and important factors were analyzed weekly, and the results showed that the fastest growth rate (productivity rate) was recorded in the second week at 23.27 g.day-1. After that, biomass yield was steadily decreased to 11.67 g.day-1 in the fourth week. The ranges of the experimental cultivation conditions were salinity (29.13 - 31.54 ppt), pH (8.42 - 9.41), air temperature (12.14 - 35.13ºC), water temperature (21.02 - 24.64ºC), light intensity (0 - 35,350.00 lux), electrical conductivity, EC (46.67 - 48.62 ms.cm-1), total dissolved solids, TDS (25.22 - 26.14 g.l-1) and alkalinity (74.00 - 106.67 mg.l-1). During cultivation, the EC was high and the values were quite stable. The amount of ammonia-nitrogen, nitrite-nitrogen, nitrate-nitrogen ranged were 0.17 - 7.20, 2.04 - 8.51 and 2.06 - 3.60 mg.l-1, respectively. The amount of inorganic phosphorus (phosphate phosphorus) was between 0.58 - 0.91 mg.l-1. The nutritional value of cultivated sea grape was performed by dry algal weight and the amount of protein, fat, moisture, ash, fiber and carbohydrate were 24.44 ± 4.329, 2.07 ± 0.13, 8.53 ± 0.40, 38.99 ± 0.30, 14.50 ± 1.28 and 11.47%, respectively. This artificial seawater grown algae contained a high amount of protein (24.44%), and our study results show that artificial seawater cultivation presents positive production of nutritions.
Synthesis and characterization of TiO2 and palm oil fiber ash hybrid photocatalysts for seawater pretreatment
Authors: Abdulkarim Abdulrahman Mohamed Suliman  , Ruzinah Isha  , Mazrul Nizam Abu Seman  , Abdul Latif Ahmad
Published: October 2021

Titanium dioxide (TiO2) has been used in various applications such as air purification, water purification, and photoelectrochemical conversion systems. However, developing advanced materials with enhanced performance for catalytic applications, especially water treatment, is highly required. This work aims to study the effect of (TiO2) photocatalyst in pretreatment seawater desalination. The catalyst with a mass ratio of TiO2: palm oil fibre ash (POFA) at 0:100, 40:60, 60:40, and 100:0 was synthesized via wet impregnation. The catalyst was calcined at 500 ℃ for four hours. The mixture of artificial seawater and catalyst at a mass ratio of photocatalyst: artificial seawater at 1:300 was put in a one-litre borosilicate photo-reactor fixed with mercury light of 350 nm for two hours with stirring at 1000 rpm. In this investigation, an evaporator was used to collect the freshwater. The fresh and spent catalysts were characterized via X-Ray Diffractogram (XRD), Nitrogen physisorption analysis, Diffuse Reflectance Spectrometer (DRS), Scanning Electron Microscopy (SEM), and Energy Dispersive X-Ray Spectroscopy (EDX). The catalyst with Ti: palm oil fibre ash (POFA) at 40:60 and 60:40 can reduce the COD at 45 % and 41%, respectively. As more OPFA was added into the hybrid TiO2 catalyst, there has been a change in the properties of seawater due to the use of special evaporators, especially EC and TDS. It can be deduced that the hybrid TiO2 photocatalyst synthesized with OPFA has vast potential to treat seawater.
Eco-friendly natural rubber latex and modified starch-based adhesive for wood-based panels application- A review
Authors: Triveni Soubam  , Arun Gupta
Published: October 2021

The use of formaldehyde-based synthetic adhesives for the development of wood-based panels has increased rapidly in the industry. Synthetic adhesives are regarded as a threat to human health and a pollutant because they emit formaldehyde's carcinogenic gas. The breakthrough has prompted to seek for a long-term solution to the formaldehyde threat with natural resources. There has been a significant rise in bio-based adhesive technology and development in the wood-based panel industry. The current review article is intended to present the potentials and the drawbacks of the development of bio-adhesives from sustainable resources such as natural rubber latex (NRL) and starch. This review also discussed the chemical modification and crosslinkers of starch to improve water resistance and adhesion properties. Moreover, this article discusses the compatibility of modified rice starch and NRL for their conclusive applications as wood-based panels adhesive. The findings suggested that bio-based adhesives could replace more synthetic-based adhesives with comparable performance in the near future.
Evaluation of cattail characteristics as an invasive wetland plant and biomass usage management for biogas generation
Authors: Obey Gotore  , Vadzanayi Mushayi  , Sawitree Tipnee
Published: October 2021

The fossil fuel-based linear economy has many severe drawbacks, including the need for energy security and the resulting environmental degradation. In a new cycle of the bio-economy that is becoming increasingly important, biomass waste has been used to generate energy while reducing pollution and greenhouse gas emissions. The growth of renewable energy will be substantial in the reduction of greenhouse gas emissions in order to achieve the ambitious goal of becoming carbon neutral by the mid-century. It appears that using anaerobic digestion technology to produce methane-rich biogas from biomass has a great deal of potential in this scenario. The cattail fresh and dry biomass substrate with pig wastes as inoculum was tested for biogas production. Cattail's highly complex lignocellulosic structures make it challenging to decompose as a biogas substrate. Alkaline pretreatment is one of the efficient tools in solubilizing lignin. As a result, chemical pretreatment of biomass (2 % sodium hydroxide) was a unique method for increasing biogas generation by reducing complex polymers of lignocellulosic materials into simpler molecules that microorganisms could digest. The fresh and dry biomass substrate added fermenter was produced with 57% and 60% methane, respectively.