bluuebunny/crossref_metadata_2025 huggingface dataset:
COVID-19, NEUROCOVID-19 AND COGNITIVE IMPAIRMENT IN ELDERLY AND OLD PATIENTS (literature review)
Authors: Курмаев Д.П. , Булгакова С.В. , Тренева Е.В. , Косарева О.В. , Шаронова Л.А. , Долгих Ю.А.
Published: May 2023

Новая коронавирусная инфекция COVID-19 вызывает поражение многих органов и систем, является полиорганным заболеванием. Многие исследователи изучают связь новой коронавирусной инфекции с полиморбидной патологией, старческой астенией, саркопенией. Вирус SARSCoV-2 обладает свойством тропности к нервной ткани, поэтому в спектр клинических проявлений и последствий перенесенной болезни могут присоединяться ольфакторные, вкусовые нарушения, а также нарушения когнитивных функций. Болезнь Альцгеймера является самой частой причиной деменции в мире. Представляет интерес наличие связи между перенесенной коронавирусной инфекцией и развитием когнитивных нарушений, в том числе болезни Альцгеймера.

The new coronavirus infection COVID-19 causes damage to many organs and systems, is a multi-organ disease. Many researchers are studying the relationship of the new coronavirus infection with polymorbid pathology, frailty, sarcopenia. The SARS-CoV-2 virus has the property of neurotropism, therefore, olfactory, taste disorders, as well as cognitive impairments can join the spectrum of clinical manifestations and consequences of the disease. Alzheimer’s disease is the most common cause of dementia in the world. It is of interest that there is a link between the coronavirus infection and the development of cognitive impairment, including Alzheimer’s disease.
PROBLEMS OF CHOOSING HYPOGLYCEMIC THERAPY IN ELDERLY PATIENTS (literature review)
Authors: Булгакова С.В. , Долгих Ю.А. , Шаронова Л.А. , Косарева О.В. , Тренева Е.В. , Курмаев Д.П.
Published: May 2023

Сахарный диабет 2-го типа (СД2) является одним из распространенных неинфекционных заболеваний в мире. Среди лиц с СД2 преобладают пациенты старшей возрастной группы — 60,5 % всех больных старше 65 лет, а пик распространенности приходится на возраст 65–69 лет. Лечение этой патологии у пациентов пожилого возраста имеет определенные особенности, что связано с высоким уровнем полиморбидности. Терапия СД2 должна быть направлена не только на компенсацию уровня гликемии, но и на лечение и профилактику осложнений СД, улучшение качества жизни больных. При выборе сахароснижающей терапии следует учитывать влияние препаратов на сердечно-сосудистую систему и функцию почек, а также риск гипогликемии, которая чаще встречается у лиц старшего возраста и влияет на когнитивную функцию таких пациентов. В данном обзоре рассмотрены возможности использования у больных пожилого и старческого возраста различных групп сахароснижающих препаратов.

Type 2 diabetes mellitus is one of the most common non-infectious diseases in the world. Among people with type 2 diabetes, patients of the older age group predominate: 60,5 % of all patients are over 65 years old, and the peak prevalence is at the age of 65–69 years. The treatment of this pathology in elderly patients has certain features, which is associated with a high level of polymorbidity in these patients. Therapy for type 2 diabetes should be aimed not only at compensating the level of glycemia, but also at treating and preventing complications of diabetes, and improving the quality of life of patients. The choice of hypoglycemic therapy should take into account the effect of drugs on the cardiovascular system and kidney function, as well as the risk of hypoglycemia, which is more common in older people and affects the cognitive function of such patients. This review discusses the possibilities of using various groups of antidiabetic drugs in elderly and old patients.
Eskuinetiko erlatiboak euskaraz, izen ardatzaren ondoretik (ere) hedatzen direnak (eta V). Ikuspegi orokorra
Authors: Hidalgo Eizagirre Víctor
Published: May 2023

Artikuluan bateratzen ditu autoreak aurreko beste zenbait lanetan atalka aztertutako euskarazko izen ardatzaren eskuinetiko erlatiboen gaineko datu estatistikoak (erlatibo hautsiak, izen ardatz determinatugabeen ondoko erlatiboak eta izen ardatz determinatuen ondokoak -(e)n… aposizioak, zein… erlatiboak, bait- erlatiboak). Eta eskuinetiko erlatiboon erabileraren lotura aztertzen da (batzuetan zuzena) esaldi erlatiboen luzerarekin. Bai eta ere esaldi erlatibo hauen kokagunearekin esaldi nagusiko aditzaren aurre edo ondorenean. Aldi berean ematen da, eskuinetiko erlatiboen erakusgarri, aurreko artikuluetan jaso gabeko aho zein idatzizko beste hainbat erabilera adibide berri. Amaitzeko, eskematikoki erakusten dira esaldi erlatibo jokatuen aukerak euskaraz, nola hauen ordez ahozko hizkeran sistematikoki erabili ohi diren beste zenbait egiturarenak ere.
Gramatikalizazio-prozesu bat: Baina enklitikoa
Authors: Rotaetxe Amusategi Karmele
Published: May 2023

Azterlan honek proposatzen du -Baina enklitikoa deritzan euskal unitatea eskala batean sailkatzea, non tarteko lekua hartuko lukeen baina juntagailuaren eta kontzesiorako menderagailuen artean. Hipotesi hau justifikatzeko, aipatutako unitatea aztertzen da bere ezaugarri semantiko eta formalen bidez. Portaera fonikoa eta distribuzioaren portaera bezalako probek agerian uzten dute ez dela juntagailua, baina juntagailuaren idatzitako forma bera badu ere. Baina beste proba formal batzuk ikusita, ezin da -baina enklitikoa menderagailuen artean kokatu, nahiz eta bere esangurak kontzesio menderakuntzaerlazioa adierazten duen. Horregatik esaten da [–juntagailu], [–menderagailu] elementua dela. Azpimarratzen da -baina enklitikoak duen mugikortasuna esaldiko elementu ezberdinei eransteko, eta ez bakarrik aditz jokatuei, menderagailu kasuetan jazoten denez. Propietate honen azalpena gramatikalizazio prozesu batean bilatu behar dela aipatzen du ikerlanak. -Baina enklitikoak gramatikalizazio prozesu batean sartuta izanez gero, baina juntagailua baino gramatikalagoa da baina kontzesio-menderagailuak baino gutxiago. Antzeko prozesua katalanez ere ematen da, non bukatuta dagoen; euskaraz, ordea, amaitu barik dugu.
El euskara en la administración navarra a finales del XVIII. Tensa relación entre el hospital y el ayuntamiento de Pamplona
Authors: Urrizola Hualde Ricardo
Published: May 2023

En el presente artículo se da cuenta del nombramiento, por parte de la corporación pamplonesa, de un capellán para el Hospital General de Pamplona que no sabía hablar ni entender la lengua vasca. La situación que se creó con este nombramiento, novedoso por ser el primero que se hizo en sacerdote no euskaldun, aparece reflejada en unas cartas que se cruzaron entre la junta del hospital, órgano gestor de la institución, y el alcalde y concejales de Pamplona, verdaderos patronos del hospital. A lo largo de este artículo se puede comprobar el enfrentamiento que hubo entre dos grandes poderes: el civil, encarnado por la corporación de Pamplona, y el religioso, representado por altos cargos de la catedral y de la orden de San Juan. Como eje de la polémica aparece lo que los religiosos llamaban “ayudar a bien morir”. Aparecen también en este artículo diversas informaciones sobre otros casos, siempre relacionados con el Hospital General, en los cuales destaca la importancia que en esos años se le daba al conocimiento del euskera, a fin de garantizar un buen servicio a todos los ciudadanos de Navarra.
Defensive lawfare and deterrence: Analysis of Latvia’s approach to legal bases in the context of hybrid warfare (2014-2022)
Authors: Bodnieks Valerijs
Published: May 2023

Following the ‘hybrid form’ of Russian aggression in Ukraine that emerged in 2014, the period after February 24th, 2022 is referred to as the ‘new reality’. Hence, the question that needs to be addressed is how to deter and prevent Russian aggression of this kind. The national legal framework against the aggressor is a part of the deterrence policy and can be construed as defensive lawfare. Focusing on Latvia, the aim of the paper is to analyse defensive lawfare and deterrence in the context of hybrid warfare. The following research question has been identified: What is Latvia’s approach to establishing defensive lawfare in terms of hybrid warfare? For the empirical analysis, the chronological framework has been set from 2014 to 2022. To complete the empirical analysis of the present paper, both qualitative and quantitative research has been implemented comprising document analysis and semi-structured interviews, as well as content analysis, respectively. The improvement of a regulatory base and the development of deterrence, whilst using regulatory acts, is an element of deterrence and a way to act legally. The law can be used as a weapon. Lawfare, a concept with three definitions, has two forms: defensive a nd offensive. Latvia’s legal base includes a regulation to overcome hybrid threats and to implement a broad-spectrum of defence measures. Latvia’s regulatory framework is designed for defence purposes, whilst also being a way of promoting deterrence. Decision makers must be able to manoeuvre with the powers assigned to them.
STRATEGI PENGEMBANGAN INDUSTRI ALAT BERAT DI BALI (STUDI KASUS CV. DANA KARYA)
Authors: Mandira I Made Chandra , Cahya Damayanti Gusti Agung Ayu Putu
Published: May 2023

This study aims to develop a marketing strategy that can be applied to heavy equipment rental CV. Dana Karya in order to survive from similar competitors. The research method uses mixed methods with an exploratory research approach. Data collection techniques were carried out by means of interviews, questionnaires and documentation which were tested using technical triangulation. Informants were obtained through purposive sampling technique as many as 7 people, namely, company owners, employees and customers. This study was analyzed using the SWOT analysis technique using weights, ratings on IFAS and EFAS calculations which were then analyzed using the business life cycle. The results of this study indicate that the company's position obtained from the results of the total score of IFAS and EFAS is in quadrant 1 by implementing an aggressive growth strategy (growth-oriented strategy) that focuses on SO (Strength – Opportunities) strategy by utilizing all of the company's internal strengths to seize and take advantage of opportunities externally as much as possible. Based on the classification of internal - external factors, it is obtained that the IE matrix which is in cell 1 shows CV. Dana Karya is in a growth and build position. In relation to the business life cycle, the position of CV's heavy equipment rental business can be identified. CV. Dana Karya is currently in the growth phase.
A STUDY ON INTERNET AWARENESS, INTERNET ATTITUDE AND INTERNET BROWSING BEHAVIOUR AMONG B.Ed., TRAINEES IN THANJAVUR DISTRICT.
Authors: R. Ravitha A. , Vaishnav R.
Published: May 2023

The main objective of the study is to nd the Internet awareness, Internet attitude, Internet browsing behavior among the
B.Ed., Trainees in thanjavur district with their different dimensions of Age, Gender, Major subject ,Qualication ,Type of
college, Gender of college ,Locality of college and Internet usage time. To analyse Internet awareness, Internet attitude, Internet browsing
behavior among the B.Ed., Trainees by collecting the data from thanjavur district B.Ed., college students. For this investigation, a questionnaire
developed the scholar to seek the information from the student teachers. we took 300 samples to investigate and the result shows there is no
signicant difference in the Internet awareness of the B.Ed., trainees and in all dimensions with respect to the variables. The study also showed a
signicance difference in men and women student teacher related to the Internet attitude. The Internet browsing behavior have signicant
inuence on the B.Ed., trainees in thanjavur district.
CHALLENGES IN MANAGEMENT OF BORDERLINE LEPROMATOUS LEPROSY COMPLICATED BY DAPSONE INDUCED HEMOLYTIC ANEMIA AND LEPRA REACTION: A CASE REPORT.
Authors: Mohan Ajay , Jamadar Shubham , Pai Kalpita , Dongre Pushkar
Published: May 2023

Multidrug therapy for Leprosy is currently done with Dapsone, Clofazimine and Rifampicin. Dapsone is known to cause
hemolytic anemia and this adverse event during MDT seems to be more frequent than reported. Lepra reactions can occur
at presentation, during treatment or even after completion of MDT. Inadequate and interruption of treatment is an obstacle to eradication. 65 year
old female clinically diagnosed leprosy, as patient developed multiple hypopigmented plaques on skin and swelling and decreased sensation over
right hand initiated on MDT presented with complains of hematuria on Day 4 of therapy. Blood investigation revealed hemolytic anemia.
Dapsone was stopped and blood products given. Dapsone inhibits bacterial synthesis of Dihydrofolic acid. The main side-effects usually
described are allergic, such as itchy rash and exfoliative dermatitis, hemolytic anemia (HA), jaundice, methemoglobinemia and dapsone
syndrome. Type 1 reaction or “reversal reaction" presents with worsening of pre-existing skin lesions, thickening of nerve ber with neuropathy
and edema. Type 2 reaction or erythema nodosum leprosum (ENL) have painful erythematous skin nodules. This case highlights fundamental
understanding of the treatment options, prompt diagnosis and treatment of reactions which are essential to reduce disease burden and improve
patient's quality of life.
TECHNOLOGICAL CHALLENGES IN LAST MILE ON DEMAND FOOD DELIVERY : PERSPECTIVE FROM FOOD DELIVERY RIDERS WITH SPECIAL REFERENCE TO COIMBATORE CITY, TAMILNADU, INDIA
Authors: K S Sumina , Gomathi M.
Published: May 2023

On-demand food delivery workers play an important role in the ODFD (On-Demand Food Delivery) supply chain. This
study investigates the technological problems that riders encountered while delivering meals. A questionnaire distribution
was done in order to gather information from users of the Swiggy and Zomato platforms, and 100 people participated in the study. The study's
ndings imply that the respondents are dealing with a variety of difculties, including technological ones brought on by the device (a mobile
phone) and platform algorithmic setup..The key problems are the overall setup of the algorithm, its boss-like forcefulness, lack of safety as a result
algorithmic setup, and its boss-like setup.
AFFORDABLE REHABILITATION OF A POST-COVID MUCORMYCOSIS ORBITAL DEFECT BY AN ACRYLIC ORBITAL PROSTHESIS: A CASE REPORT
Authors: Tasar Doyir , Acharya Anaida , Sahoo Jyotirmayee , Patro Tapan Kumar , Dhal Angurbala , Garhnayak Lokanath , Kumar Ullash
Published: May 2023

Mucormycosis is a fungal infection caused by inhalation of Mucor and Rhizopus spores in the atmosphere. While healthy
individuals are mostly immune to these fungi, immunocompromised patients are susceptible and can develop a severe
infection. The Post- Covid Pandemic Indian population had seen many immunocompromised patients suffering from mucormycosis. This was
frequently treated with antifungal therapy and surgical excision which often lead to formation of oro-nasal communication and orbital defects.
This case report includes rehabilitation of an orbital defect caused as a complication of post- covid mucormycosis by 2-piece magnet and
anatomical undercut retained acrylic orbital prosthesis.
METHYLPREDNISOLONE - THE SAVIOR IN CHILDREN WITH MULTISYSTEM INFLAMMATORY SYNDROME (MIS-C)
Authors: Anand Anand , S M Spoorthi , K B Chethan , Patil Mugunagowda
Published: May 2023

Background: Multisystem inammatory syndrome in children (MIS-C), also known as pediatric inammatory
multisystem syndrome is a new entity and is fatal disease that is temporally associated with SARS-COV 2
(PIMS-TS) [1]. We aimed at studying varied clinical presentation, management and outcome in children with MIS-C associated with
covid-19 treated with IvIg and methylprednisolone at tertiary care centre, Davangere. This is a retrospective observational Methods:
study conducted at two tertiary care hospitals at Davangere from October 2020 to August 2021 (11 months.). All cases who fullled
WHO criteria for MIS-C were included in the study. Institutional ethics committee approval was taken. Data was obtained from
hospital records .Parameters studied were demographics, symptomatology, laboratory markers, medications and immediate outcome. All
children were then grouped into 2. Group 1- those who presented with shock and group 2- those who presented without shock . Data
were entered and analyzed using SPSS software version 22.0. For interpretation of results signicance was adopted at p-value less
than 0.005 and at 95% condence interval. A total of 182 patients w Results: ith MIS-C were treated during the study period. The
median age of presentation was 6.8±4.5 years. We had 14 cases of infants. M:F ratio 1.35:1 showing no sex predilection. Children who
presented with shock had signicant symptoms of pain abdomen, tachypnoea, Lower GCS and lower saturation levels and had
signicantly higher CRP, LDH, ferritin, D-dimer levels and had lower albumin levels which is statistically signicant . Also
requirement of IVIg was signicantly more in children with shock (TABLE 2). Out of 182 children with MIS-C, only 21 received
IVIg and rest all received only steroids - methylprednisolone ( due to nancial constraints ). However the outcome did not vary much
with IVIg or steroids. IV methylprednisolone pulse therapy was associated with favorable immediate outcome which is comparable
with IVIg in our study. Mortality in our series was 6.04% which is comparable to international studies [11,12]. In our Conclusion
study most of our children with MIS-C recovered with timely use of pulse methylprednisolone therapy alone with favourable short
term outcomes. Thus in resource limited settings methylprednisolone pulse therapy can help in saving lot of young children with MISC.
HYPONATREMIA SERVING AS A MORTALITY INDICATOR FOR ACUTE ST ELEVATION MYOCARDIAL INFARCTION
Authors: A. Soni Namita , Bharadwaja Malempati , Paramshetti Siddhiraj , Koleti Kranthi
Published: May 2023

INTRODUCTION: Acute ST-elevation myocardial infarction (STEMI) is a clinical syndrome involving myocardial
ischemia, ECG changes and chest pain. In the developed world, the incidence and prevalence of coronary artery disease
has decreased signicantly over the last three decades whereas it has increased in the developing world. Hyponatremia, dened as a serum
sodium concentration of less than 135 mmol/l, has prevalence ranging from 12.5% to 23.2% in patients with STEMI7 and around 25 % in
patients with heart failure8. Hyponatremia is common after MI, though may not be a complication, is associated with adverse outcome in
hospitalized patients. The plasma sodium concentrations rise, once the clinical improvement sets in. AIM: To nd prognostic importance of
hyponatremia in acute ST elevation myocardial infarction. MATERIALS& METHODS: 94 cases of Acute ST-elevation myocardial infarction
(STEMI) fullling inclusion and exclusion criteria were enrolled in present study . After an overnight fasting, blood was taken for general routine
investigations and lipid prole. Serum sodium levels were obtained on admission(day0), on day1, day2 and day3 along with 2D
echocardiography ndings on admission. RESULTS: In survivors' group have mean age of 51.0±12.44, 21% were females and 79% were males,
22% with hyponatremia, 44% were smokers, 23% were diabetics, 17% were hypertensives, 79% were in Killip class I 19% were in Killip class II,
1% in Killip class III and 1% in Killip class IV and mean ejection fraction was 43.23±3.35 as compared to non-survivors' group. Odd's ratio for
30day mortality is higher in groups with hyponatremia i.e., Group2 (6.88) and Group3 (4.00) when compared to Group1 i.e., (0.06) suggesting
increased risk of mortality with hyponatremia. Hyponatremia on admission or early CONCLUSION: development of hyponatremia in acuteSTEMI patients can be used as an independent predictor of 30day mortality.
CLINICAL PROFILE OF POLYCYTHEMIA IN SMALL FOR GESTATIONAL AGE NEONATES ADMITTED TO THE NEONATAL INTENSIVE CARE UNIT OF A TERTIARY CARE HOSPITAL
Authors: Saharia Kangkan , Narayan Baruah Manab , Biswanath Pranabjit , Kumar Nath Ananta
Published: May 2023

Background:-Polycythemia is the principal cause of hyperviscosity of blood in neonates and is associated with serious,
sometimes life threatening complication of the brain, heart, kidney, lungs and intestines. The incidence is high in small
for gestational age neonates. To assess the incidence, clinical prole of Aim:- polycythemia among Inborn small for gestational age newborns
admitted in the Neonatal Intensive Care Unit of Jorhat Medical College and Hospital. Objectives:-To determine the incidence of polycythemia
among small for gestational babies admitted in the Neonatal Intensive Care Unit of Jorhat Medical College & Hospital, and to assess the pattern
of clinical manifestations and complications attributable to polycythemia. Method:-130 consecutive small for gestational age inborn babies
admitted into the NICU of Jorhat Medical College and Hospital, Jorhat during the period of 1 year from May 2021 to April 2022 were screened
for polycythemia at 2 - 4 hours of postnatal age using venous hematocrit. The newborns were considered polycythemic if the venous hematocrit
was ≥65%. The incidence of polycythemia in small for gestational age was 31.5% Results:- (41 out of 130 babies). Among the 130 small for
gestational age babies, 57 were preterm,49 were term and 24 were post term. The incidence of polycythemia was 29.2%in preterm, 36.7 % in
term and 24.3% in post term babies. Among the polycythemic babies, icterus(70.7%) was the commonest clinical manifestation followed by
lethargy (60.9%) and tachypnoea (36.5%).Hyperbilirubinemia (70.7%) was the commonest laboratory abnormality followed by
thrombocytopenia(63.4%), hypokalemia (17.07%) , hypernatraemia (9.7%), hypoglycaemia (7.3%) , hypocalcemia (7.3%), hyperkalemia
(4.8%) and hyponatremia (2.4%).39 babies underwent partial exchange transfusion with normal saline for correction of polycythemia. There
was improvement in clinical features and hematocrit levels following partial exchange transfusion. Two asymptomatic babies did not undergo
partial exchange transfusion and were managed conservatively. Conclusion:-Polycythemia is a silent clinical condition which if unrecognized
can result in signicant morbidity in neonates. As incidence is high in small for gestational age newborns, these babies must be actively screened
for its timely detection and management in order to prevent complications attributable to polycythemia-hyperviscosity syndrome. Key words:-
Neonatal polycythemia, small for gestational age, Hematocrit, Partial exchange transfusion
SUBXIPHOID VIDEO ASSISTED THORACOSCOPIC SURGERY (VATS) FOR CHEST TRAUMA AND COMPLICATIONS
Authors: Srivastava Ayush , Kansal Akshit
Published: May 2023

Introduction: Subxiphoid approach Video Assisted Thoracoscopic Surgery (VATS) is a minimally invasive surgical
technique which can applied to variety of thoracic procedures with unanimous results even in emergency conditions such
as chest trauma. This paper presents uniport-subxiphoid approach Video Assisted Thora Aim: coscopic Surgery (VATS) used in chest trauma and
its detailed analysis. In this study, a total of 30 patients from November Material and Methods: 2022 to March 2023 underwent Subxiphoid
approach Video Assisted Thoracoscopic Surgery (VATS) for the management of haemothorax and complications post chest trauma. In a Result:
total of 30 patients from November 2022 to March 2023, Single port subxiphoid approach Video Assisted Thoracoscopic Surgery (VATS) was
used to successfully conclude the surgery essential in all these patients presenting to Teerthanker Mahaveer Medical College and Hospital, post
chest trauma. Additionally, 3 patients who developed bronchopleural stula post chest trauma also underwent correction using uniport
subxiphoid Video Assisted Thoracoscopic Surgery (VATS). No postoperative wound infection was noted. Complete Haemothorax removal was
achieved in all these patients. There was no case noted of post operative wound infection. All the patients were discharged early. Conclusion:
Classical Median Sternotomy is the standard approach for haemothorax evacuation as indicated in previous studies. However, access through
classical median sternotomy is associated with a higher risk of local infection and sternal instability. Additionally, it may sometimes be burdened
with a high perioperative risk due to massive mediastinal adhesions in the late postoperative period. The uniport subxiphoid approach Video
Assisted Thoracoscopic Surgery (VATS) is an effective procedure for evacuating haemothorax and correcting chest complications post trauma.
Subxiphoid Video Assisted Thoracoscopic Surgery (VATS) intervention is also associated with decreased rates of chest infections and superior
cosmesis. Moreover, it signicantly reduced the duration of ventilator dependency. The clinical outcomes were signicantly better for patients
undergoing uniport Subxiphoid Video Assisted Thoracoscopic Surgery (VATS).
RAPID DIAGNOSIS OF RESPIRATORY DISTRESS SYNDROME BY ORAL ASPIRATE IN PREMATURE NEWBORNS – A PROSPECTIVE COMPARATIVE STUDY
Authors: Ahmad G Jakati Asif , Gowda Manje , Chandrashekar Chandrashekar
Published: May 2023

Background and Objectives: Respiratory distress syndrome is common in premature infants; frequency is inversely
proportional to gestation and birth weight. RDS is mostly caused by surfactant deciency. For the diagnosis of RDS in
newborns, the stable microbubble test on gastric aspirate and amniotic uid has been employed. The major goal of this study was to assess how
well the stable microbubble test might predict RDS from oral aspirates of preterm babies. A prospective comparative study was Methodology:
done on 73 inborn preterm neonates of AJIMS, Mangalore over the period of 18 months. Neonates with gestation <37weeks were included in the
study. Oral sample was collected as soon as baby delivered. Stable microbubble test was done for all the babies, number of stable microbubbles
were compared between newborns with RDS and newborns without RDS. Number of stable microbubbles were also compared with requirement
of surfactant, use of CPAP and ventilator. The mean number of stable microbubbles i Results: n those with RDS was 17.77 SD ± 6.746 and in
those without RDS was 31.14 SD ± 8.26. At a cut-off level of ≤25 microbubbles with Sensitivity 87%, specicity 78.57%, PPV 75% and NPV
89.2%. The ndings of our study suggest that sensitivity of chest x-ray in detecting RDS was 77.4%, specicity 92.86%. The negative and
positive predictive value of chest x-ray in detecting RDS were 84.78% and 88.89% respectively. In comparison to Chest X ray in Conclusion:
detection of RDS, stable microbubble test was found to be more sensitive at a cut off value of <25 stable microbubbles. However, specicity was
found to be better with chest x-ray. Hence, stable microbubble test can be considered as a better screening test for RDS in preterm.
A STUDY ON ASSOCIATION OF MATERNAL AND CHILD HEALTH VARIABLES WITH BIRTH SPACING IN INDIA
Authors: Sahu Priyanka , M. H. Zaidi S. , Mishra Prabhaker , Mishra Shambhavi
Published: May 2023

Introduction- Birth spacing is an important element of the population growth of any country and has a strong relationship
with maternal and child health. It is dened as the time interval between two consecutive live births of children.
Methodology- The present study used secondary data from NFHS-4 that was conducted in 2015-2016. We restricted our sample to those
reproductive women age 15-49 years who had reported at least two pregnancies in the reproductive calendar, with the most recent of those births
having occurred in ve years preceding the survey. If women had more than two children then birth spacing of last two was taken for analysis. This
study included, a total of 104907 women in the nal analysis sample. Majority 82027 Results- (78.2%) women were residing in rural areas of
India while 228880 (21.8%) were residence of urban area. 44376 (42.3%) of the women had age group of 25-29 years. Approximately three fourth
76591(73.0%) mothers have given birth to 2-3 children. Male child preponderance was seen in this analysis. Caesarean section was done in 11198
(10.7%) mothers. The authors suggest that authorities from union and state governments, hea Conclusion- lth ofcials, other stakeholders and
policymakers should contribute towards improving birth spacing practices through various educational campaigns, family planning activities
and benets to the couples having 2 children at the prescribed birth interval promoting good health of mothers as well as child.
THE ADVERSE EFFECT OF HEALING COMPLICATIONS TO THE OUTCOME OF GBR – A 'SPLIT MOUTH' CASE REPORT
Authors: Giragosyan Krikor , Ivanova Vasilena , Chenchev Ivan
Published: May 2023

Inadequate alveolar process width and height can be overcome by the utilization of distraction osteogenesis, split crest
technique or a sinus lift, however many clinical scenarios require the use of guided bone regeneration (GBR). When
vertical deciencies are present, the collective opinion is that non-resorbable membranes should be employed in the augmentation procedure.
While remaining form stable throughout the healing period is advantageous for vertical regeneration, the non-resorbable membranes' biological
properties do not aid the primary intention closure over the grafted region in any way. As a result, membrane exposures occur which have
emphatically negative effect on the regeneration process. There certainly is an abundance of evidence on the detrimental effect of healing
complications on the GBR process, however the information regarding the outcome of the bone regeneration process involving exposed vs
unexposed sites in the same individual is scarce.
A STUDY OF JOB SATISFACTION AND MENTAL HEALTH OF HIGHER SCHOOL TEACHERS IN THANJAVUR DISTRICT
Authors: Maslin Abila A. , Selvaraj T.
Published: May 2023

This is the overall pattern, or integration of his structure, modes of behavior, interests, attitudes, intellectual abilities,
aptitudes and many other distinguishable characteristic.. Viewing a person as he goes, we usually obtain a total impression
of his personality as ''agreeable'','' disagreeable'','' dominating '',''submissive'' about the various activities of his everyday life or the like.
Psychology, however, vises the individual more analytically. Little can be done scientically with an overall impression . Thus, if the person
comes under psychological experiment on personality his behavior may be observed in various situations. Thus the term personality refers to the
whole individual Therefore, to identify the attitude of teachers towards teaching profession in relation to their job satisfaction is the need of hour.
The most distinctive feature of any individual is his personality Hence, the investigator attempts to study the attitude of teachers towards teaching
of higher school teachers relation to their job satisfaction
A PROSPECTIVE RANDOMISED CLINICAL TRIAL TO EVALUATE THE EFFECT OF FIBULAR PLATING IN TWO STAGED TREATMENT OF TIBIAL PLAFOND FRACTURES
Authors: Dutta Nayanmoni , Gayan Mondeep , Kumbang Protul , N.G Harikrishnan
Published: May 2023

Introduction: A single blinded randomized clinical trial of distal plafond fractures , who were treated with primary
external xation with and without bular plating followed by distal tibial plating .Sincere efforts were made to analyze
and compare the results of bular xation and staged protocol in tibial plafond fractures. A prospective study was Materials and Methods:
conducted for 40 cases of tibial plafond fractures who were aged between 18yrs - 65yrs and presented within 2 weeks of injury. Randomization
was done to allocate 20 patients each into two treatment models – a)External xation with bular plating , b)External xation without bular
plating. Second stage distal tibial lock plating was done in all cases and follow up was carried out. Results: Statistically signicant differences
were found in case of operating time, duration of hospital stay in favour of external xation without bula plating group, but these may not be
clinically signicant. Delay in second stage tibial plating was more in bular plating group. Fibula plating reduces rotational malalignment more
signicantly than coronal and saggital plane malalignment. There is no signicant early union , malunion or nonunion on comparing both groups.
Both the procedures gave equally good functional results. We recommend two stage protoc Conclusion: ol for management of plafond fracture to
decrease complication rate and bular xation is not always necessary in those cases with undisplaced lateral column. Displaced bular fractures
which destabilize the ankle mortise should always be picked up for bular plating.
TEMPORARY PACEMAKER INSERTION CAUSING RIGHT VENTRICLE PERFORATION WITH CARDIAC TAMPONADE AND DIAPHRAGMATIC INJURY.
Authors: Srivastava Ayush , Kansal Akshit , Garg Akash
Published: May 2023

Cardiac perforation post pacemaker insertion is a rare complication. However, acute right ventricular perforation
presenting with hemopericardium leading to cardiac tamponade is a life-threatening condition which may prove fatal
without urgent intervention. The diagnosis is based on clinical presentation of the patient post procedure along with chest Xray, Computed
tomography (CT) scan and echocardiographic study. Management of the perforation is based on clinical assessment of the patient. Rapidly
progressing pericardial effusion or neighbouring organ injury result in haemodynamic instability for which urgent surgical intervention is
indispensable.
UNUSUAL PRESENTATION OF LUPUS NEPHRITIS IN A 22 YEAR OLD MALE : A CASE REPORT
Authors: Pawar Akshay , Jamadar Shubham , Gaikwad Madhukar , Pawar Abhijeet
Published: May 2023

Systemic lupus erythematosus (SLE) is an autoimmune disease in which organ and cell undergo damage initially
mediated by tissue binding autoantibodies & immune complexes.In most patients, autoantibodies are present for a few
years before the rst clinical symptoms appears. It is ve to six times more prevalent in women than in men .Nephritis is usually the most serious
manifestation of SLE, particularly because nephritis and infection are the leading cause of mortality in the rst decade of disease. We present a
case of a 22 yr old male who came with complaint of bilateral pedal oedema and pufness of face since 1 month . On examination, patient was
stable hemodynamically with pulse of 88 per minute, blood pressure of 110/80 millimeter of mercury with room air saturation of 99 percent and
jugular venous pressure of 6-7 millimeters of water. He also had pallor in lower palpebral conjunctiva and bilateral pitting pedal oedema.There
was no clubbing, icterus,cyanosis or lymphadenopathy. His routine blood investigations showed anaemia , leucocytosis , elevated creatinine,
hyperkalaemia , hypoalbuminemia, iron deciency ,urine routine microscopy suggestive of RBC cast 60-70/high power eld . Complement C3
and C4 were low, ANA positive grade 3(1:1000) homogeneous and cytoplasmic speckled, ANA BLOT positive for dsDNA, nucleosome,
Histones, Sm/RNP,Mi2b.His ultrasound (USG) revealed bilateral bulky kidney and heterogeneous with raised cortical echogenicity and normal
size. His renal biopsy was done which showed diffuse lupus nephritis(ISN/RPS2018 modication)class IV and indices(modied NIH) of
activity 15/24 and chronicity 2/12, necrotizing vascular lesions along with evidence of vascular immune deposits in diffuse immunoorescence
studies and associated inammatory cells are noted. Patient received intravenous pulse therapy of methyl prednisolone 1gram for 5 days with
monitoring of kidney function test. Patient was put on cyclophosphamide with hemodialysis for immunosuppression because patient was not
responding to steroids, as seen by rising serum creatinine and urea levels and declining urine output. The patient improved dramatically, urine
output increased and serum creatinine and urea decreased, therefore haemodialysis was discontinued, and the patient was managed
conservatively and discharged on oral prednisolone with a monthly cyclophospmide injection.
A REVIEW STUDY ON GREEN SYNTHESIS OF SCHIFF BASES
Authors: Sharma Ankit , K. Arora S.
Published: May 2023

Green chemistry offers signicant nancial and environmental advantages over traditional synthesis methods. It
accomplishes this by subtly suggesting methods and tools. The present interest in green chemistry has proposed a further
necessity for organic synthesis, where novel reaction conditions must locate, lowering the demand for hazardous ingredients or damaging organic
solvents. These green approaches must improve selectivity, speed up reaction times, and facilitate product separation as compared to traditional
routes. The rst synthesis of Schiff bases was recorded by Hugo Schiff in the 19th century (imines). A primary amine and an aldehyde are often
combined to form a Schiff base, which is an aldehyde with an azomethine group (C=N group) instead of a C=O group. In order to determine the
best approach that gives greater yields in less time while maintaining an environmentally friendly atmosphere, this study aims to concentrate on
the green synthetic techniques utilised for Schiff bases synthesis. The review considered a number of environmentally friendly synthetics
methods, among which microwave irradiation is considered to be the best, followed by ultrasonic, employing natural acids, and grinding
techniques.
CASE REPORT ON SPLENIC CYST- A SURGICAL ARCANE!
Authors: P. Gayathre S. , Kalaiselvi P. , Silambuselvi K.
Published: May 2023

Splenic cyst is a rare clinical presentation with an incidence of 0.07% in general population and are mostly asymptomatic. According to the
presence or absence of cellular epithelial lining, these cysts are classied into primary and secondary cysts. A splenic cyst (ICD-10 code D73.4) is
considered rare because it does not always manifest itself, and it is not so easy to nd it in the spleen covered with the peritoneum. Often a cyst of
this localization is detected during an examination of the abdominal cavity for a completely different reason.[1] We Report a case of Symptomatic
Splenic cyst which was successfully intervened surgically
A STUDY 0F PREVALENCE OF ANEMIA IN CKD PATIENTS ADMITTED IN GUWAHATI MEDICAL COLLEGE AND HOSPITAL.
Authors: Kalita Ajay , Ch Kalita Bipul
Published: May 2023

Background:Chronic kidney disease (CKD) is characterised by impaired kidney function, a persistent decline in glomerular ltration rate (GFR),
and a spectrum of diverse pathophysiologic processes. Anemia in CKD may be treated and identied early, which may reduce cardiovascular
morbidity and mortality. Early anemia treatment in CKD patients may delay the onset of ESRD and increase survival. Materials And Method:
A hospital based observational study was conducted in different units of Medicine department of Guwahati Medical College and Hospital during
the period from 1st July 2021 to 30th June 2022 enrolling 100 patients who fullled the inclusion criteria. Results: In the present study anemia was
present in all cases. The hemoglobin (Hb) level ranged from 3.5 to 11gm/dl with mean of 7.97 gm/dl. Majority (61%) of the cases had Hb level
between 7-10 gm/dl and 32% had Hb level less than 7gm/dl. The hemoglobin distribution was categorized into mild, moderate and severe and then
prevalence of anemia in different stages of CKD was obtained. It showed Stage 5 CKD to have statistically signicant anemia for Hb<9gm%.
Conclusion: It was found that all the subjects in the study group had anemia. The severity of anemia progressed with stage of the disease. I
Therefore, it is crucial to handle anemia in chronic kidney disease patients so that the appropriate measures can be taken to stop the progression of CKD.
CORRELATION BETWEEN BRANDWEIN-GENSLER'S HISTOLOGIC RISK MODEL AND BRODER'S HISTOLOGICAL GRADING IN ORAL SQUAMOUS CELL CARCINOMAS
Authors: Sharma Saket , P. Hiryur S. , Akbari Suruchi , Bhungaliya Radhika
Published: May 2023

Introduction: Several clinicopathological and molecular factors have been used to prognosticate and predict outcomes in the patients of oral
squamous cell carcinomas (OSCC). Many histological grading systems have been described, however there is a lack of agreement as to a
satisfactory robust predictive model. The Brandwein-Gensler risk model has been validated in various multicentre studies as a reliable prognostic
model for advanced as well as early disease. The Broders grading system, still recommended by WHO, is probably the best-known attempt at
prognostication with subjective assessment of key histological features. This study was conducted to evaluate various histological prognostic
markers in case of Oral Squamous Cell Carcinomas (OSCC) and understand their correlation with each other. Total 66 Materials and Methods:
excised specimens of Oral squamous cell carcinomas were retrospectively analysed and Histologic risk scoring was done according to the
Histologic risk model (HRM) given by Brandwein-Gensler et al. Broder's histological grading was done on the basis of differentiation of tumor.
Results: Histological grading of tumor based on differentiation of tumor shows poor correlation with Brandwein-Gensler's Histologic risk model
with a sensitivity and specicity of 34.7% and 52.9% respectively; inferring that differentiation status of tumor is not a good parameter for
prognostic evaluation of Oral Squamous Cell Carcinomas. However, owing to the fact that no poorly differentiated tumor was noted in the current
study, further evaluation and large sample size is required to conrm. Researc Conclusion: h on predictive and prognostic biomarkers has ignited
hope for individualizing therapy to facilitate better survival and reduce overtreatment in the patients of oral SCC. There is no signicant association
between differentiation of tumor and WPOI. No signicant correlation exists between differentiation of tumor and Histologic risk model scoring
thereby inferring that histological differentiation of tumor is not a good prognostic parameter.
FUNCTIONAL OUTCOME OF INTRA-ARTICULAR CALCANEAL FRACTURES FIXED WITH PERCUTANEOUS SCREWS - A PROSPECTIVE STUDY
Authors: A Anish , James Boblee , M Antony Abraham , T Kamalesh , Anand Gokul , G Kamalakannan
Published: May 2023

Background: The treatment of displaced calcaneum fractures has been a subject of intense discussion. Displaced intra-articular calcaneum
fractures gives poor result with conservative treatment and requires reduction and internal xation for favourable long-term results. Open
procedures are more prone to complications regarding wound healing. Percutaneous xation offers a middle pathway in treating simpler variety of
displaced calcaneal fractures. The aim of the study was to access the functional outcome of intra articular fracture calcaneum managed with closed
reduction and percutaneous screw xation. This study was done in department of Orthopa Methods: edics Aarupadai veedu Medical college and
hospital, Pondicherry. Twenty-six intra-articular calcaneal fractures treated with closed reduction and percutaneous screw xation under image
intensier. For the research, 26 individuals of either sex were accepted. Patients received thorough information about the trial, and formal written
consent was acquired. The study was conducted from August 2020 to September 2022. The follow-up phase lasted up to 6 months. Analysis and
research were conducted on the outcomes of 26 fractures in 26 individuals. The examined data was discussed and compared to comparable series in
the literature. A master chart that covers all the factors and variables taken into account was posted. Twenty-six cases evaluated (one Results:
patient had lost follow-up), all fractures were united, average time of union was 8 weeks. The mean AOFAS score was 73.08% of 26 patients had
good, 23.08% patients had fair and 3.85% patients had poor result on a 6 month follow up. Average postoperative Bohler's angle 26.42 degrees and
post-operative Gissane angle was 122 degrees. Treatment of intra-articular frac Conclusions: tures of calcaneum is challenging but close reduction
and internal xation with 4.5 cannulated cancellous screws yields favorable outcome in majority of cases.
ROLE OF PLATELET TRANSFUSION IN DENGUE PATIENTS WITHS BLEEDING TEN
Authors: Bhatt Dipali , Parekh Manushi , Chavada Jitendra , N Shah Shaila
Published: May 2023

Introduction: Dengue fever and dengue hemorrhagic fever (1) are usually a benign condition caused by an arthropod borne virus and bleeding is one of the dreaded complications associated with higher mortality in DHF/DSS (1) Dysfunction of platelets are Prothrombotic complications associated with severe cases of dengue. Thus, platelets could be considered cells that are active against the anti DENV immune response. Platelet transfusion is given in those patients who are either bleeding or having other hemorrhagic symptoms along with thrombocytopenia. AProspective study was conducted of 100 dengue positive patients with bleeding tendency in department of pathology, Government medical college and Sir. T. Hospital, Bhavnagar, Gujarat during period of July 2020 to MAY 2021.The patient who received multiple platelet transfusions showed post transfusion platelet increment of >0.5x105/mm3 from each unit
EFFECTIVENESS OF ULTRASOUND GUIDED SUPRASCAPULAR NERVE BLOCK BY PULSED RADIOFREQUENCY ABLATION AND METHYLPREDNISOLONE INJECTION WITH LIGNOCAINE IN IMPROVING UPPER LIMB FUNCTION IN HEMIPLEGIC PATIENT WITH SHOULDER PAIN A RANDOMIZED CONTROLLED STUDY
Authors: Deb Suman , Bimol Naorem , Anamika Chanu Yendrembam , Miku Wuppi
Published: May 2023

Objective:- To compare the effectiveness of ultrasound guided suprascapular nerve block by pulsed radiofrequency ablation and
methylprednisolone injection with lignocaine in improving upper limb function in hemiplegic patient with shoulder pain Methods:- Sixty patients
with hemiplegia with shoulder pain were included in a prospective, randomized controlled trial, which were distributed in two groups. The study
group received ultrasound guided pulse radiofrequency ablation (PRFA) of suprascapular nerve, while the control group received single injection
of 80mg methylprednisolone and 2 ml of 2% lignocaine. Outcome measures used were MAS (Motor assessment scale), VAS (visual analogue
scale), SPADI (shoulder pain and disability index) and assessment were done at baseline, 1 week, 4 weeks and 12 weeks follow ups. Results:-All
outcome measures in the study group and in the control group showed signicant improvement from the baseline (P< 0.05). Acomparison of the 2
groups indicated signicantly greater improvement in the study group at all times in MAS, VAS and SPADI scores (all P< 0.05). Conclusions:The
present study found that ultrasound guided pulsed radiofrequency ablation and methylprednisolone block of suprascapular nerve rendered
improvement in upper limb function and pain till 12 weeks. However, in terms of faster onset of disability reduction with greater pain relief, pulsed
radiofrequency ablation of suprascapular nerve showed statistically signicant improvement in almost all outcome measures. Therefore, it is
suggested that it might be the treatment of choice in future for improving upper limb function in patients with hemiplegia with shoulder pain.