bluuebunny/crossref_metadata_2025 huggingface dataset:
Uncertainty-aware prediction of chemical reaction yields with graph neural networks
Authors: Kwon Youngchun , Lee Dongseon , Choi Youn-Suk , Kang Seokho
Published: January 2022

In this paper, we present a data-driven method for the uncertainty-aware prediction of chemical reaction yields. The reactants and products in a chemical reaction are represented as a set of molecular graphs. The predictive distribution of the yield is modeled as a graph neural network that directly processes a set of graphs with permutation invariance. Uncertainty-aware learning and inference are applied to the model to make accurate predictions and to evaluate their uncertainty. We demonstrate the effectiveness of the proposed method on benchmark datasets with various settings. Compared to the existing methods, the proposed method improves the prediction and uncertainty quantification performance in most settings.
1,3-Butadiene: a ubiquitous environmental mutagen and its associations with diseases
Authors: Chen Wan-Qi , Zhang Xin-Yu
Published: January 2022

1,3-Butadiene (BD) is a petrochemical manufactured in high volumes. It is a human carcinogen and can induce lymphohematopoietic cancers, particularly leukemia, in occupationally-exposed workers. BD is an air pollutant with the major environmental sources being automobile exhaust and tobacco smoke. It is one of the major constituents and is considered the most carcinogenic compound in cigarette smoke. The BD concentrations in urban areas usually vary between 0.01 and 3.3 μg/m3 but can be significantly higher in some microenvironments. For BD exposure of the general population, microenvironments, particularly indoor microenvironments, are the primary determinant and environmental tobacco smoke is the main contributor. BD has high cancer risk and has been ranked the second or the third in the environmental pollutants monitored in most urban areas, with the cancer risks exceeding 10-5. Mutagenicity/carcinogenicity of BD is mediated by its genotoxic metabolites but the specific metabolite(s) responsible for the effects in humans have not been determined. BD can be bioactivated to yield three mutagenic epoxide metabolites by cytochrome P450 enzymes, or potentially be biotransformed into a mutagenic chlorohydrin by myeloperoxidase, a peroxidase almost specifically present in neutrophils and monocytes. Several urinary BD biomarkers have been developed, among which N-acetyl-S-(4-hydroxy-2-buten-1-yl)-L-cysteine is the most sensitive and is suitable for biomonitoring BD exposure in the general population. Exposure to BD has been associated with leukemia, cardiovascular disease, and possibly reproductive effects, and may be associated with several cancers, autism, and asthma in children. Collectively, BD is a ubiquitous pollutant that has been associated with a range of adverse health effects and diseases with children being a subpopulation with potentially greater susceptibility. Its adverse effects on human health may have been underestimated and more studies are needed.
Gouty arthritis and kidney function outcomes and serum uric acid level variations in obese patients following bariatric surgery
Authors: Balata Mona G. , Helal Ahmed H. , Mohamed Ashraf H. , Habib Alaa-Uddin , Awad Mahmoud , Sherif Mohamed
Published: January 2022

Background

Obesity is an independent risk factor for chronic kidney disease (CKD) and is the strongest known modifiable risk factor for hyperuricemia and gout. We aimed to discover the outcome of serum uric acid (SUA), gouty arthritis, and kidney function in obese patients after bariatric surgery and possible links with BMI variations.

Methods

Retrospective study has been performed in National Hospital in Riyadh, KSA, between Jan. 2018 to Jan. 2020. We studied only 98 patients who met our inclusion criteria. Patients followed-up at 1 month (for gouty attack only) postoperative, 3 months postoperative, and 6 months postoperative for body mass index (BMI), serum creatinine, dipstick urinalysis, SUA, and estimated glomerular filtration rate (eGFR). Radiological studies, medical history, follow up radiological studies, and clinical follow up were obtained from the hospital data system.

Results

A total of 98 patients with mean eGFR were 90.65 ± 29.34 ml/min/1.73 m2, mean SUA 5.56 ± 1.84 mg/dl, and mean BMI was 45.28 ± 7.25 kg/m2, at surgery. Mean BMI had decreased significantly to 38.52 ± 6.05 kg/m2 at 3 months and to 34.61 ± 5.35 kg/m2 at 6 months (P < 0.001). The mean GFR had improved significantly (99.14 ± 23.32 ml/min/1.73 m2) at 6 months (P < 0.001). Interestingly, proteinuria had resolved in 17 patients out of 23 patients at 6 months. Number of gouty attacks was decreased during the first month post-surgery (P < 0.001). SUA level was significantly decreased (4.32 ± 1.27 mg/dl) (P < 0.001). SUA showed significant negative correlations with eGFR at 3 months and positively significant correlations with BMI at 3 and 6 months. By multinomial logistic regression, BMI and initial eGFR were the independent predictive variables for the outcome of eGFR at 6 months, while male gender and initial SUA were the independent predictive variables on the outcome of SUA at 6 months. Postoperatively in gouty arthritis patients, the number of joints affected, patient global VAS assessment, and number of gouty attacks were significantly reduced (P < 0.001).

Conclusion

Bariatric surgery has been associated with reduction of BMI and subsequently reduction of SUA levels, gouty attacks, and improvement of eGFR.
Zebrafish vascular quantification: a tool for quantification of three-dimensional zebrafish cerebrovascular architecture by automated image analysis
Authors: Kugler Elisabeth C. , Frost James , Silva Vishmi , Plant Karen , Chhabria Karishma , Chico Tim J. A. , Armitage Paul A.
Published: January 2022

Zebrafish transgenic lines and light sheet fluorescence microscopy allow in-depth insights into three-dimensional vascular development in vivo. However, quantification of the zebrafish cerebral vasculature in 3D remains highly challenging. Here, we describe and test an image analysis workflow for 3D quantification of the total or regional zebrafish brain vasculature, called zebrafish vasculature quantification (ZVQ). It provides the first landmark- or object-based vascular inter-sample registration of the zebrafish cerebral vasculature, producing population average maps allowing rapid assessment of intra- and inter-group vascular anatomy. ZVQ also extracts a range of quantitative vascular parameters from a user-specified region of interest, including volume, surface area, density, branching points, length, radius and complexity. Application of ZVQ to 13 experimental conditions, including embryonic development, pharmacological manipulations and morpholino-induced gene knockdown, shows that ZVQ is robust, allows extraction of biologically relevant information and quantification of vascular alteration, and can provide novel insights into vascular biology. To allow dissemination, the code for quantification, a graphical user interface and workflow documentation are provided. Together, ZVQ provides the first open-source quantitative approach to assess the 3D cerebrovascular architecture in zebrafish.
Aster repulsion drives short-ranged ordering in the Drosophila syncytial blastoderm
Authors: de-Carvalho Jorge , Tlili Sham , Hufnagel Lars , Saunders Timothy E. , Telley Ivo A.
Published: January 2022

Biological systems are highly complex, yet notably ordered structures can emerge. During syncytial stage development of the Drosophila melanogaster embryo, nuclei synchronously divide for nine cycles within a single cell, after which most of the nuclei reach the cell cortex. The arrival of nuclei at the cortex occurs with remarkable positional order, which is important for subsequent cellularisation and morphological transformations. Yet, the mechanical principles underlying this lattice-like positional order of nuclei remain untested. Here, using quantification of nuclei position and division orientation together with embryo explants, we show that short-ranged repulsive interactions between microtubule asters ensure the regular distribution and maintenance of nuclear positions in the embryo. Such ordered nuclear positioning still occurs with the loss of actin caps and even the loss of the nuclei themselves; the asters can self-organise with similar distribution to nuclei in the wild-type embryo. The explant assay enabled us to deduce the nature of the mechanical interaction between pairs of nuclei. We used this to predict how the nuclear division axis orientation changes upon nucleus removal from the embryo cortex, which we confirmed in vivo with laser ablation. Overall, we show that short-ranged microtubule-mediated repulsive interactions between asters are important for ordering in the early Drosophila embryo and minimising positional irregularity.
Benefits and limitations for the use of radiation dose management systems in medical imaging. Practical experience in a university hospital
Authors: Vano Eliseo , Fernández José M , Ten José I. , Sanchez Roberto M.
Published: January 2022

Objectives:

Radiation dose management systems (DMS) are currently used to help improve radiation protection in medical imaging and interventions. This study presents our experience using a homemade DMS called DOLQA (Dose On-Line for Quality Assurance).

Methods:

Our DMS is connected to 14 X-ray systems in a university hospital linked to the central data repository of a large network of 16 public hospitals in the Autonomous Community of Madrid, with 6.7 million inhabitants. The system allows us to manage individual patient dose data and groups of procedures with the same clinical indications, and compare them with diagnostic reference levels (DRLs). The system can also help to prioritise optimisation actions.

Results:

This study includes results of imaging examinations from 2020, with 37,601 procedures and 286,471 radiation events included in the radiation dose structured reports (RDSR), for computed tomography (CT), interventional procedures, positron emission tomography-CT (PET-CT) and mammography.

Conclusions:

The benefits of the system include: automatic registration and management of patient doses, creation of dose reports for patients, information on recurrent examinations, high dose alerts, and help to define optimisation actions. The system requires the support of medical physicists and implication of radiologists and radiographers. DMSs must undergo periodic quality controls and audit reports must be drawn up and submitted to the hospital’s quality committee. The drawbacks of DMSs include the need for continuous external support (medical physics experts, radiologists, radiographers, technical services of imaging equipment and hospital informatics services) and the need to include data on clinical indication for the imaging procedures.

Advances in knowledge:

DMS perform automatic management of radiation doses, produces patient dose reports, and registers high dose alerts to suggest optimisation actions. Benefits and limitations are derived from the practical experience in a large university hospital.
Can detection and prediction models for Alzheimer’s Disease be applied to Prodromal Parkinson’s Disease using explainable artificial intelligence? A brief report on Digital Neuro Signatures.
Authors: Tarnanas Ioannis , Vlamos Panagiotis , Harms Dr Robbert ,   The RADAR-AD Consortium
Published: January 2022

Parkinson's disease (PD) is the fastest growing neurodegeneration and has a prediagnostic phase with a lot of challenges to identify clinical and laboratory biomarkers for those in the earliest stages or those 'at risk'. Despite the current research effort, further progress in this field hinges on the more effective application of digital biomarker and artificial intelligence applications at the prediagnostic stages of PD. It is of the highest importance to stratify such prediagnostic subjects that seem to have the most neuroprotective benefit from drugs. However, current initiatives to identify individuals at risk or in the earliest stages that might be candidates for future clinical trials are still challenging due to the limited accuracy and explainability of existing prediagnostic detection and progression prediction solutions. In this brief paper, we report on a novel digital neuro signature (DNS) for prodromal-PD based on selected digital biomarkers previously discovered on preclinical Alzheimer's disease. (AD). Our preliminary results demonstrated a standard DNS signature for both preclinical AD and prodromal PD, containing a ranked selection of features. This novel DNS signature was rapidly repurposed out of 793 digital biomarker features and selected the top 20 digital biomarkers that are predictive and could detect both the biological signature of preclinical AD and the biological mechanism of a-synucleinopathy in prodromal PD. The resulting model can provide physicians with a pool of patients potentially eligible for therapy and comes along with information about the importance of the digital biomarkers that are predictive, based on SHapley Additive exPlanations (SHAP). Similar initiatives could clarify the stage before and around diagnosis, enabling the field to push into unchartered territory at the earliest stages of the disease.
Analysis of financial and economic activities
Authors: Golubeva Tat'yana
Published: January 2022

The textbook discusses the theoretical foundations of economic analysis as a system of knowledge about the subject and objects, method and tasks, methodology and organization of analytical work at the enterprise. The methods of managerial and financial analysis of the business entity's activities, including the calculation of reserves for improving the results of production and economic activity, are presented.
Meets the requirements of the federal state educational standards of secondary vocational education of the latest generation.
For students of secondary vocational educational institutions studying in an enlarged group of specialties 38.02.00 "Economics and Management".
Standardization, metrology and conformity assessment. Practicum
Authors: Nikolaevaya Mariya , Lebedeva Tamara , Kartashova Larisa
Published: January 2022

The textbook presents the methodology of practical work established by the work programs, as well as situational tasks. It is planned to use innovative pedagogical technologies in a number of works, such as analysis of practical situations, federal laws, standards and business games. The textbook is an addition to the textbook by M.A. Nikolaeva and L.V. Kartashova "Standardization, metrology and conformity assessment".
Meets the requirements of the federal state educational standards of higher education of the latest generation.
For university students studying in the areas of training 38.03.06 "Trade business" and 38.03.07 "Commodity science".
Accounting in the restaurant and hotel business and tourism
Authors: Kas'yanova Svetlana
Published: January 2022

The textbook outlines the theoretical and applied aspects of the organization and accounting features, which allow assessing the effectiveness of its management with a proper degree of completeness and reliability. The latest legislative changes have been taken into account.
All the material is distributed on topics between theoretical, practical and seminar classes, as well as independent work of students in the form of discussions, presentations, situational tasks, test tasks.
The use of methodological materials will allow students to rationally allocate their time while studying the discipline, get a sufficiently adequate aggregate score and rating assessment and form professional skills.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
The textbook contains a set of developments for the preparation of bachelors in the field of accounting that meet the requirements of the educational program in the field of training 38.03.01 "Economics".
Introduction to the profession of "architect"
Authors: Oselko Ninel'
Published: January 2022

In the textbook, the author shows the future specialist what opportunities knowledge and skills give for practical activity, how wide is the field of architecture, where each student can find what he will eventually do.
It provides theoretical training and is designed to broaden the horizons of a young architect, to show the necessary tools for self-improvement in the profession.
For students, postgraduates and teachers of architectural and construction universities, as well as anyone interested in architecture and construction.
Fundamentals of professional intercultural communication
Authors: Baryshnikov Nikolay
Published: January 2022

The textbook examines the fundamental problems of professional intercultural communication, outlines the main components of the professional competence of a specialist in intercultural communication, his personal qualities necessary for successful professional activity.
The author's concept of attack strategies and self-defense strategies in the communicative battles of professionals is presented.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
For students studying in the areas of training and specialties: 45.03.02 "Linguistics": profiles "Theory and practice of intercultural communication" and "Theory and methodology of teaching foreign languages and cultures"; 45.05.01 "Translation and translation studies"; 41.03.05 "International relations"; 41.06.01 "Political sciences and regional studies". It is also of interest to specialists in the field of intercultural communication.
The system "seaport - "dry" port"
Authors: Murav'ev Dmitriy , Rahmangulov Aleksandr , Osincev Nikita , Kornilov Sergey , Cyganov Aleksandr
Published: January 2022

The monograph presents an approach to solving the problem of increasing the throughput and processing capacity of seaports in conditions of limiting their territorial dislocation and increasing the unevenness of external and internal cargo flows. The basis of the approach is the proposed system of the main parameters of the dry port and the methodology of simulation modeling of the functioning of the system "seaport - dry port". The material is illustrated with examples of the implementation of the developed approach, including model scenarios of multi-agent optimization of the parameters of the system under study. The proposed approach and the developed methodology can be used to justify management decisions on the balanced development of transport and logistics infrastructure of the regions hosting sea and dry ports.
It is intended for specialists of transport and logistics companies, engineering and technical workers engaged in solving problems in the field of logistics, supply chain management and transport infrastructure design. In addition, it is recommended to students in the following programs: postgraduate studies 23.06.01 "Land transport engineering and technology" (focus "Transport and transport-technological systems of the country, its regions and cities, organization of production in transport") and 27.06.01 "Management in technical systems" (focus "Management of transportation processes"); master's degree 23.04.01 "Technology of transport processes" (profile "Organization of transportation and management in a single transport system"); bachelor's degree 38.03.02 "Management" (profile "Logistics") and 23.03.01 "Technology of transport processes".
Digital labor platforms: new forms of labor organization and regulation
Authors: Savel'eva Ekaterina
Published: January 2022

The monograph presents an extensive study of new forms of labor organization in the context of the development of technical, technological, financial, economic and socio-cultural factors. The distinctive features of digital labor platforms, their classification, as well as the strategies of key players in the global and Russian-speaking distance labor markets are given. Based on the analysis of current international analytical reviews, foreign and domestic scientific publications, current legislation and court decisions, the author gives approaches and methods of regulatory regulation of platform labor.
The author does not ignore such controversial issues as: direct and indirect methods of state influence on the activities of digital labor platforms, problems of social responsibility, as well as prospects for the development of platform cooperativism in the world and Russia as an alternative to labor platforms focused on the global level.
It is of interest to researchers, government authorities, teachers of higher educational institutions, graduate students and students studying these problems.
Environmental sustainability control system of economic entities
Authors: Chhutiashvili Lela
Published: January 2022

The monograph is devoted to a comprehensive analysis of the environmental sustainability control system of economic entities, both internal (internal control services) and external (state supervision (control) and audit). Effective control of the environmental sustainability of economic entities carried out by audit organizations and internal control units in cooperation with state supervision (control) and audit of nature users is carried out in order to verify the compliance of the nature of their environmental activities, products and environmental management systems with current legislation, standards, rules, requirements in the field of environmental protection and to confirm the reliability of their reporting. Confirming the reliability of the reporting of economic entities, environmental supervisors are able to conduct an independent assessment of the environmental sustainability and effectiveness of the environmental activities of the audited organizations, issue their proposals and recommendations for making informed decisions by various stakeholders.
The interaction of audit organizations with the internal control (audit) services of enterprises and state supervision (control) and audit bodies will contribute to the timely preparation of reliable accounting and consolidated financial statements by enterprises and increase the efficiency of their environmental activities.
It is intended for researchers, students, postgraduates and undergraduates, entrepreneurs, managers and anyone interested in the problems of environmental sustainability control of economic entities.
Evil: the experience of philosophical research
Authors: Gorohov Pavel
Published: January 2022

The monograph is devoted to a holistic consideration of the phenomenon of evil. It examines and analyzes philosophical ideas about the nature of evil, which can be found among outstanding thinkers. The figure of the Devil as the main antagonist of God, the "fallen angel" and the progenitor of evil is studied. The main and, in the author's opinion, the most important types and modes of evil, such as hatred, meanness, betrayal, crime, etc., are analyzed.
Designed for everyone interested in the problems of modern philosophy, cultural studies and ethics.
Rowing electric installations: overview, analysis, development prospects
Authors: Burkov Aleksey , Mihanoshin Viktor
Published: January 2022

The monograph provides an overview and analysis of ship's rowing electrical installations, modern scientific and technical solutions aimed at improving the theory and practice of electrical systems of ship propulsion systems are considered. Solutions of urgent problems related to the development of rowing electric installations of small-tonnage vessels based on the introduction of combined power plants, including electrochemical sources of electricity (batteries), are proposed.
It is intended for scientific and educational purposes and is aimed at specialists in the field of ship power engineering, cadets and students of electromechanical specialties of educational institutions.
Theoretical aspects of the formation and development of the ecological economy in Russia
Authors: Gadzhiev Nazirhan , Konovalenko Sergey , Trofimov Mihail
Published: January 2022

The monograph is devoted to the place and role of ecology and environmental safety in ensuring sustainable socio-economic development of society. In the conditions of the forced transition of the economies of the leading countries of the world from an industrial type to a new formation of a green economy aimed at ensuring the preservation of ecological systems and the maximum reduction of damage to the biodiversity of ecological systems, the Russian Federation faces the task of forming a new course of socio-economic development of society focused on the preservation of natural potential and ecology at a level normal for the maintenance of the vital activity of society, flora and fauna in the foreseeable future and in the long term.
The role and importance of environmental safety in the system of ensuring the economic security of the state are outlined, the concept of the ideology of "Global Commons" in ensuring sustainable socio-economic development of society is considered, the problems and prospects of the implementation of the program "Green Course of Russia" are analyzed, special aspects of environmental audit, accounting and control, damage assessment in the field of ecology are investigated. Special attention is paid to the forecast of the dynamics of key environmental indicators for the medium term. The main directions of increasing the effectiveness of the mechanism for ensuring environmental safety in a market economy are proposed.
For a wide range of readers interested in environmental economics. It will be useful for students, postgraduates and teachers of economic universities.
Competitiveness of organizations and territories
Authors: Antonov Gennadiy , Ivanova Ol'ga , Tumin Valeriy , Kostromin Petr
Published: January 2022

The textbook discusses the issues of managing the competitiveness of organizations and territories, including the theory of competition, its role in the economy, types and strategies of competition.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
It is intended for university students studying in bachelor's and master's degrees in the areas of training "Management", "Economics", "State and Municipal Management", "Housing and communal infrastructure", "Trade", "Quality Management", as well as in engineering and technological areas and specialties studying disciplines of economic, organizational and managerial cycles; for graduate students, students of business schools and advanced training and retraining courses. It can be useful for university teachers, employees of research and consulting firms, business structures, managers and specialists of enterprises.
CONTROL SUPPLY OF THE COST-MANAGEMENT SYSTEM OF ENTERPRISES
Authors: Klychova Guzaliya , Zakirova Alsu , Nigmatullina Nuriya , Zakirov Zufar , Nurieva Regina
Published: January 2022

In modern conditions, a number of factors affect the activities of enterprises, which include a tough competitive environment, limited material resources, and the economic crisis caused by the COVID-19 pandemic. To improve its efficiency, it is necessary to minimize the costs of manufacturing products, performing work and providing services. Effective and rational internal control contributes to the solution of this task. In this regard, issues related to the organizational and methodological support of control over production costs are of particular relevance. The research was carried out in order to study organizational aspects and develop directions for improving the methodological support of internal control of production costs. As one of the internal control tools, it is advisable to use the internal control working document (ICWD) “Test for assessing the accounting system of production costs”, which allows you to collect information on the validity and reliability of accounting for production costs and calculating the cost of production; on the procedures used in the system of internal control over production costs and the effectiveness of these procedures; on the general principles of organizing the primary, synthetic and analytical accounting of production costs, on the rationing of material resources at the enterprise. To systematize the information collected during the internal control of primary accounting, the ICWD “Checking the primary accounting of production costs” is suitable. Using the ICWD developed within the framework of the study “Checking compliance with the norms of consumption of material assets in production”, it is possible to establish the validity of material costs and generalize the results of checking the norms of inventories for production. For internal control of work-in-progress, it is proposed to use the ICWD “Questionnaire for assessing the organization and accounting of inventory of work in progress”.
STRUCTURE OF CEREAL-LEGUME HERBALS WITH DIFFERENT METHODS OF SOWING AND IRRIGATION IN ARID CONDITIONS OF THE LOWER VOLGA
Authors: Kudryashova Natal'ya , Bulahtina Galina , Kudryashov Aleksandr , Hyupinin Andrey
Published: January 2022

In recent years, livestock farms in the Astrakhan region have mainly used grasses from natural hayfields and pastures for fodder. But, due to the sharp aridization of the climate, and, as a consequence, the more frequent droughts, as well as the unregulated growth of the number of animals on farms, the reserves of natural herbage are often insufficient. Therefore, the region began to increase the area of sown hayfields for irrigation. The aim of the work is to study the effect of various irrigation methods on the productivity of cereal-leguminous mixtures with multi-cut use in the conditions of light chestnut soils of the Northern Caspian region. The studies were carried out in 2017-2020 in the Astrakhan region. All studied irrigation methods (sprinkler irrigation, drip irrigation with a belt laying depth of 0.0, 0.15, 0.25, 0.35 and 0.45 m, periodic flooding), with the exception of subsoil irrigation, with an ordinary method of sowing contributed to the development of both cereals and legumes. In these variants of the experiment, cereals occupied a significant part in the total herbage - from 40.0 to 61.0%. When using the spread sowing method, only in one variant, the share of cereal grasses was 54.0% (periodic flooding). In all others with this method of sowing, the amount of cereals in the total mass was insignificant, or they were completely absent. The widespread method of sowing was also the most productive in all the years of research. The maximum yield in the experiment was noted in all variants of the experiment in the third year of the life of grasses in 2019.The highest productivity with the spread method of sowing was noted in 2019 in the variants of the experiment with a belt laying depth of 0.25, 0.35 and 0.45 m and amounted to 98.1, 104.4 and 111.0 t/ha, respectively. In the variants with the row-sowing method, the yield was lower than with the wide-spread one. The highest yield with this method of sowing was also noted in 2019 in variants with subsurface drip irrigation with a belt laying depth of 0.35 and 0.45 m and amounted to 105.5 and 104.8 t/ha, respectively
PRODUCTIVITY AND QUALITY EVALUATION OF TARRAGON AND THYME GROWN UNDER ARTIFICIAL LIGHT
Authors: Makarov Petr , Makarova Tatyana , Samoylenko Zoya , Gulakova Natalya , Kravchenko Inessa
Published: January 2022

The research aimed at evaluation of productivity and quality of tarragon and thyme medicinal material was carried out on hydroponic installations during 2019-2020. The objects under study were Monarkh and Gudvin tarragon varieties as well as Medok and Zmeyka thyme varieties. The plants were grown in mineral cotton substratum. Fertikea Hydro complex fertiliser with microelements and calcium nitrate were used. The growing conditions: ambient temperature +22…+25℃, solution temperature +20℃, ambient humidity 55…65%. Experiment regimens: growing under white LEDs (luminous flux 8000 lm, color temperature 4000 K, PPF 165 mkmol/s/m2) and color LEDs (combination of red, blue and white LEDs (32:16:32), luminous flux 6573 lm, PPF 143 mkmol/s/m2), for 16-hour light regimen. We found that thyme grown on a vertical hydroponic system increase its biomass 2.0…3.5 times compared to the conventional growing. The highest productivity of Zmeyka thyme variety is reached under white light, while for both the tarragon varieties and Medok thyme variety it is reached under coloured LEDs. Chlorophyll-a content in green biomass is a little higher under coloured LEDs for Zmeyka thyme variety and Gudvin tarragon variety, while the reverse trend is observed for Monarkh tarragon variety. All the varieties show higher chlorophyll-b content under coloured LEDs. Combined chlorophyll-a and chlorophyll-b content increases under coloured LEDs for the thyme varieties and Gudvin tarragon variety. Monarkh tarragon variety shows the highest combined chlorophyll content under white LEDs. Carotenoid concentration in Medok thyme variety and Monarkh tarragon variety is higher under white LEDs and it is higher under color LEDs for the rest of the varieties. Flavonoids in the studied varieties accumulate statistically better (1.5…3.0 times) under white LEDs
NUTRITIONAL VALUE OF GRAIN VARIETIES OF SPRING BARLEY OF TATAR RESEARCH INSTITUTE SELECTION
Authors: Blohin Vasiliy , Nikiforova Irina , Ganieva Irina , Serzhanov Igor
Published: January 2022

Four varieties and 3 promising lines of spring barley breeding by Tatar Research Institute of Agriculture were studied for grain nutrition to identify the most promising ones. The work was conducted in 2015-2017 in Predkamye Republic of Tatarstan. Grey forest soil, humus content 3.35-3.52 % (GOST 26213-91), alkaline-hydrolyzable nitrogen 85.0...94.0 mg/kg (by A.H. Kornfield), mobile phosphorus 251...287 and exchangeable potassium 149...167 mg/kg (by Kirsanov; GOST 26207-91). The predecessor is winter rye, the repetition is fourfold, the standard grade is Raushan. It was found that line k-295-12, on average over 3 years, significantly exceeded the standard by 27.77 g in crude protein content; by 20.0 g in digestible protein content and by 7.35 g in digestible protein content per feeding unit. The variability of sugar content in varieties was 30.67 ... 47.0 g, significantly exceeded the standard by 13.33 g variety Tevkech (47.0 g) and by 13.0 g line k-23-13 (46.67 g). The fat content was formed in the standard 19.03 g, varieties Kamashevsky, Endan and lines k-23-23, k-561-13 and k-295-12 exceeded it by 7.47; 5.77; 11.47; 9.84 and 5.67 g, respectively. The exchange energy content in grain ranged from 14.42 MJ of the variety Raushan, to 14.72 MJ of the line k-295-12, with no significant differences between genotypes. In the dry year of 2015, the crude and digestible protein content was 148.0...165.0 and 110.74...118.8 g, respectively, and in 2016 it was 129.00...164.4 and 92.88...118.37 g, respectively. In favorable 2017, the content of crude and digestible protein were lower, the varieties Raushan and Tevkech were characterized by the greatest decrease in crude and digestible protein (65.7 and 67.4 % to the level of 2015). On average over 3 years, the best line was k-295-12 for the set of indicators of grain nutrition
Implementation of the optimal construction of a combination device and evaluation of reliability by output voltage
Authors: Makarenko F. , Yagodkin A. , Zolnikov Konstantin , Denisova O.
Published: January 2022

The theoretical propositions of the algebra of logic are considered. It is noted that the current microcircuitry based on the algebra of logic contains logical statements: true (yes) is a logical unit, false (no) is a logical zero. Based on the given logical function: ((ABC)×D + A×(BCD) + A×(BC)×D + (AB)×(CD), frontal, minimal, transformed minimal variants of the combination device are implemented, as well as minimized variants in the bases "AND-NOT" and "OR-NOT". A combination device based on import-substituting chips of 155, 176 series has been designed. The analysis of the obtained devices is made from the standpoint of technical and economic indicators, in particular, an assessment of the number of logic elements used, an assessment of the symmetry of the structure, as a result, a reduction in energy consumption, an increase in performance, improvements in parameters for reliability of functioning, a decrease in weight and size characteristics. Assuming that the law of change of the information parameter U1 is close to linear, taking into account the effect of temperature as boundary values for the elements of the applied microcircuits, taking the values -60 °C and +120°. Accordingly, the parametric reliability of the optimal implementation of the device according to the output voltage parameter is calculated. The conclusion is made about the inverse dependence of parametric reliability on temperature growth. A recommendation is given when evaluating parametric reliability for a number of other information parameters about the need to take into account both the number of chips used and the type of their interconnections.
Sensitivity analysis and test results of the electronic component base to the effects of heavy charged particles
Authors: Zolnikov V. , Yagodkin A. , Antsiferova V. , Evdokimova Svetlana , Skvortsova Tatyana , Grosheva Ekaterina
Published: January 2022

The work is devoted to the study of the sensitivity of the electronic component base (ECB) to the effects of heavy charged particles. At the same time, the degree of sensitivity is distinguished depending on the functional group of ECB products to the effects of ionization radiation from outer space and on the design and technological design of ECB products. The paper presents the characteristics and conditions for the use of ECB in the radio-electronic equipment of outer space to ensure minimal sensitivity to the effects of ionization radiation and to the thyristor effect. After the sensitivity analysis of ECB products is carried out, a preliminary selection of ECB is performed, requiring testing. The article discusses the criteria for determining the ECB that requires testing and is possible to use without testing. The methods of increasing the durability of radio-electronic equipment of space equipment and the directions of optimization of the methodology of analysis of ECB lists are determined.
R&D of the PERT basic model for project planning
Authors: Novikova Tatyana , Evdokimova Svetlana , Novikov A.
Published: January 2022

The guiding principles of project implementation are planning. The discrepancy in time, cost, and quality between the plan and the actual implementation of the project requires management decisions supported by an analysis of the optimization of the duration of the project and the search for reserves to reduce the implementation time. For this purpose, a basic PERT model for a specific project was developed, early and late deadlines for work, time reserves, and a critical path were calculated. This work is aimed at applying methods of evaluation and analysis of projects to find optimal solutions and control the efficiency of time and costs in project planning, by varying the work on the project and the executors of the work. The results of this study showed that there are quite large time reserves for works 5-7, 7-9, 6-9, etc., which makes it possible to redistribute work between performers and allows you to vary performers during the implementation of several projects simultaneously.
Kategorie otwierające na neuroróżnorodność studentów
Authors: Cierzniewska Ryszarda , Podgórska-Jachnik Dorota
Published: January 2022

Celem badań jest próba wydobywania i nadania sensów i znaczeń istotnym kontekstom pracy pedagogicznej prowadzonej przez nauczyciela akademickiego ze studentami neuroróżnorodnymi Niezbywalną okolicznością uprawiania myśli i praktyki edukacyjnej jest rzeczywistość systemowa, instytucjonalna i społeczna oraz usytuowanie w niej człowieka wraz z jego trancendentalnością, specyficznością w każdym wymiarze bytu. Przedmiot badań, jakim jest neuroróżnorodność studentów, został osadzony w ramy (kontekst) trzech kategorii służących opisowi kategorii neuroróżnorodności i edukacji studentów neuroróżnorodnych. Wybrane kategorie to: autorstwo własnego życia, samostanowienie i emancypacja. Nie deklarujemy ich szczegółowej charakterystyki, natomiast wydobywamy wątki służące ukazaniu ich potencjału dla otwarcia dyskusji naukowej o neuroróżnorodności. Motywem docelowym jest jednak wpisanie praktyki dydaktycznej w paradygmat myślenia i działania akademickiego zgodnego z kategorią neuroróżnorodności. Kierunek hermeneutycznej pracy wyznacza problem główny: Jaka jest istota procesu kształcenia w uczelni wyższej studentów neuroróżnorodnych? Hermeneutyczne rozważaniach prowadzone są logice paradygmatu konstruktywistycznego odnoszącego się do dydaktycznych i społecznych wymiarów tworzenia rzeczywistości edukacyjnej. Materiał badawczy stanowią teorie oraz opublikowane teksty źródłowe z przeprowadzonych eksploracji, dotyczące różnych wymiarów obecności w uczelni wyższej studentów ze spektrum autyzmu.
Różnice płci w odstępowaniu od przestępczości
Authors: Biel Krzysztof
Published: January 2022

Odstąpienie od przestępczości stało się w kryminologii i praktyce resocjalizacyjnej dominującą kategorią badawczą ostatnich dekad. Coraz lepsze rozumienie procesu wraz z identyfikacją czynników wspierających odstąpienie od przestępczości pozwala na stosowanie bardziej adekwatnych praktyk resocjalizacyjnych i wzmacnianie aktywności przestępców w ich dążeniu do zerwania z życiem przestępczym. Niniejszy artykuł ma na celu prezentację współczesnej wiedzy o procesie odstąpienia od przestępczości u kobiet i mężczyzn. Najpierw autor prezentuje główne ujęcia definicyjne. Następnie analizuje czynniki strukturalne i indywidualne obecne w procesie odstąpienia od przestępczości. Akcentowane są przede wszystkim różnice występujące u kobiet i mężczyzn. Mężczyźni odstępują od przestępczości w wyniku działania czynników związanych ze statusem społecznym (zatrudnienie, małżeństwo), podczas gdy kobiety akcentują rolę czynników związanych z relacjami osobistymi (rodziną, przyjaciółmi, znajomymi, kuratorami, terapeutami) w procesie zmiany. Analiza literatury stanowi niezbędny etap zrozumienia procesu odstąpienia od przestępczości, co pozwala na projektowanie i prowadzenie badań własnych wśród różnych grup przestępców. Na koniec autor podaje wskazówki dla praktyki resocjalizacyjnej: trzeba wierzyć w potencjał osoby i go wspierać, a równocześnie podejmować konieczne kroki terapeutyczne, należy wzmacniać motywację przestępców do zmiany stylu życia poprzez koncentrację na mocnych stronach jednostki, zwracać uwagę na odmienność płci w procesie odstąpienia od przestępczości oraz tworzyć przyjazne środowisko do zmiany, w którym zaangażowanych jest wiele agend społecznych.
Real dimension of the Lie algebra of S-skew-Hermitian matrices
Authors: Caalim Jonathan , Tanaka Yu-ichi
Published: January 2022

Let $M_n(\mathbb{C})$ be the set of $n\times n$ matrices over the complex numbers. Let $S \in M_n(\mathbb{C})$. A matrix $A\in M_n(\mathbb{C})$ is said to be $S$-skew-Hermitian if $SA^*=-AS$ where $A^*$ is the conjugate transpose of $A$. The set $\mathfrak{u}_S$ of all $S$-skew-Hermitian matrices is a Lie algebra. In this paper, we give a real dimension formula for $\mathfrak{u}_S$ using the Jordan block decomposition of the cosquare $S(S^*)^{-1}$ of $S$ when $S$ is nonsingular.
Suppression of the non-linear background in a multimode fibre CARS endoscope
Authors: Pikálek Tomáš , Stibůrek Miroslav , Simpson Stephen , Čižmár Tomáš , Trägårdh Johanna
Published: January 2022

Multimode fibres show great potential for use as miniature endoscopes for imaging deep in tissue with minimal damage. When used for coherent anti-Stokes Raman scattering (CARS) microscopy with femtosecond excitation sources, a high band-width probe is required to efficiently focus the broadband laser pulses at the sample plane. Although graded-index (GRIN) fibres have a large bandwidth, it is accompanied by a strong background signal from four-wave mixing and other non-linear processes occurring inside the fibre. We demonstrate that using a composite probe consisting of a GRIN fibre with a spliced on step-index fibre reduces the intensity of the non-linear background by more than one order of magnitude without significantly decreasing the focusing performance of the probe. Using this composite probe we acquire CARS images of biologically relevant tissue such as myelinated axons in the brain with good contrast.
Computing a projection operator onto the null space of a linear imaging operator: tutorial
Authors: Kuo Joseph , Granstedt Jason , Villa Umberto , Anastasio Mark A.
Published: January 2022

Many imaging systems can be approximately described by a linear operator that maps an object property to a collection of discrete measurements. However, even in the absence of measurement noise, such operators are generally “blind” to certain components of the object, and hence information is lost in the imaging process. Mathematically, this is explained by the fact that the imaging operator can possess a null space. All objects in the null space, by definition, are mapped to a collection of identically zero measurements and are hence invisible to the imaging system. As such, characterizing the null space of an imaging operator is of fundamental importance when comparing and/or designing imaging systems. A characterization of the null space can also facilitate the design of regularization strategies for image reconstruction methods. Characterizing the null space via an associated projection operator is, in general, a computationally demanding task. In this tutorial, computational procedures for establishing projection operators that map an object to the null space of a discrete-to-discrete imaging operator are surveyed. A new machine-learning-based approach that employs a linear autoencoder is also presented. The procedures are demonstrated by use of biomedical imaging examples, and their computational complexities and memory requirements are compared.
Direct-focusing surface-emitting laser
Authors: Hirose Kazuyoshi , Kamei Hiroki , Sugiyama Takahiro
Published: January 2022

Focusing is a fundamental optical technique that has been widely implemented via lenses. Here, we demonstrate direct focusing from a band-edge surface-emitting laser, whose emission area is 200 µm × 200 µm, without any lenses. To achieve this, a phase-modulating layer is incorporated into the laser cavity. This layer acts simultaneously as a lasing cavity similar to that of a photonic crystal laser and as a holographic spatial-phase modulator, which transforms the output beam into a focusing beam by slightly shifting the positions of holes from a periodic square lattice. Beam profiles along the surface normal clearly show that direct focusing occurs with a focal length and focal spot size of 310 µm and 6.1 µm, respectively. The focal length agrees well with the theoretical value, and the focal spot size is 2.0 times the diffraction-limited size, which indicates that the higher transverse modes are sufficiently suppressed. In addition, the power density at the focus is 540 times higher than that at the near-field plane. Interestingly, a focus pattern is also observed in the opposite direction at the near-field plane, which indicates that a converging beam and a diverging beam are simultaneously emitted because of the nature of the in-plane band-edge laser. The conventional beam patterns of semiconductor laser cavities are limited to the regime of two-dimensional projection based on a Fourier hologram. In contrast, we demonstrate the simplest form of a three-dimensional point cloud based on a Fresnel hologram, which is quite useful for micro-sensing applications such as microfluidics, flow cytometry, blood sensors, and endoscopy.