bluuebunny/crossref_metadata_2025 huggingface dataset:
Gads Regulates the Expansion Phase of CD8+ T Cell-Mediated Immunity
Authors: Zhang Elizabeth Yan , Parker Brooks L. , Yankee Thomas M.
Published: March 2011

The Gads adaptor protein is critical for TCR-mediated Ca2+ mobilization. We investigated the effect of Gads deficiency on the proliferation of CD8+ T cells following peptide stimulation and in the context of infection with an intracellular pathogen. We stimulated CD8+ T cells from Gads+/+ OT-I and Gads−/− OT-I mice with cognate Ag (SIINFEKL) or altered peptide ligand. In vitro experiments revealed that Gads was required for optimal proliferation of CD8+ T cells. This defect was most evident at the early time points of proliferation and when low doses of Ag were used as stimuli. Cell cycle analysis demonstrated that Gads−/− CD8+ T cells had impaired TCR-mediated exit from the G0 phase of the cell cycle. Furthermore, Gads−/− CD8+ T cells had delayed expression of c-myc and CD69 upon the stimulation with SIINFEKL. We then investigated how Gads deficiency would impact CD8+ T cell-mediated immunity in the context of infection with an intracellular pathogen. At early time points, Gads+/+ and Gads−/− CD8+ T cells proliferated to a similar extent, despite the fact that expression of CD69 and CD25 was reduced in the absence of Gads. After 5 d postinfection, Gads was required to sustain the expansion phase of the immune response; the peak response of Gads−/− cells was significantly lower than for Gads+/+ cells. However, Gads was not required for the differentiation of naive CD8+ T cells into memory cells. We conclude that the primary function of Gads is to regulate the sensitivity of the TCR to Ag ligation.
The Usefulness of Biological and Neuroimaging Markers for the Diagnosis of Early‐Onset Alzheimer′s Disease
Authors: Padovani Alessandro , Gilberti Nicola , Borroni Barbara
Published: March 2011

The recent proposed criteria for Alzheimer′s Disease (AD) have strongly claimed the usefulness of biological and neuroimaging markers for early identification AD. Cerebrospinal fluid (CSF) Tau/Abeta ratio, hippocampal atrophy, posterior cingulate, and neocortical associative area hypometabolism, or amyloid burden evaluated by PiB compound, held the premises to increase diagnostic accuracy in the preclinical disease stages. Despite many efforts to identify subjects at risk of developing AD, less attention has been paid to presenile AD diagnosis. A few data are already available in early onset AD, mainly obtained in cases of monogenic disorder. In this paper, we discuss the current literature on the role of biological and neuroimaging markers in presenile AD.
Morning vs. evening feed delivery for lactating dairy cows
Authors: Nikkhah A. , Furedi C. J. , Kennedy A. D. , Scott S. L. , Wittenberg K. M. , Crow G. H. , Plaizier J. C.
Published: March 2011

Nikkhah, A., Furedi, C. J., Kennedy, A. D., Scott, S. L., Wittenberg, K. M. Crow, G. H. and Plaizier, J. C. 2011. Morning vs. evening feed delivery for lactating dairy cows. Can. J. Anim. Sci. 91: 113–122. A study was conducted to investigate the effects of changing feed delivery time from morning (0900) to evening (2100) on feed intake, diurnal feed intake patterns, digestion, rumen fermentation, milk production and composition, as well as on several blood metabolites. Eight (four ruminally cannulated) lactating Holstein cows, consisting of four primiparous and four multiparous cows, were used in the study. The change in the time of feed delivery increased the proportion of feed consumed within 3 h of feed delivery in all cows (54.7 vs. 46.3±4.1%, means±SE, P=0.05), but increased daily dry matter intake only in primiparous cows (18.5 vs. 20.4±0.7 kg d−1, P=0.05). Average daily concentrations of blood glucose, lactate, urea and β-hydroxybutyrate (BHBA) as well as rumen pH and concentrations of volatile fatty acids (VFA) were not affected by feed delivery time. However, rumen pH was lower (P<0.05), at 5 and 6 h after feed delivery, while total rumen VFA and acetate were higher (P<0.05) only at 6 h after feed delivery in cows fed in the evening. Also, compared with feed delivery at 0900, feeding cows at 2100 resulted in lower (P<0.05) blood glucose and urea at 2 h after feed delivery, and increased BHBA (P<0.05) at 4 and 6 h after feed delivery. Cows fed at 2100 tended to produce more milk fat than those fed at 0900 (1.11 vs. 0.97±0.07 kg d−1, P=0.08). Milk yield and milk protein were not affected by the time of feed delivery. Changing the feed delivery time from morning to evening increased apparent total tract digestibility of dry matter, nitrogen, and neutral detergent fibre. The results of this study suggest that changing time of feed delivery from 0900 to 2100 increases feed consumption within 3 h after this delivery and rumen fermentation within 6 h after this delivery, changes diurnal patterns of glucose, urea and BHBA in peripheral blood, tends to increase milk fat, and increases nutrient digestibilities.
The effects of feeding untreated and formic acid-treated colostrum ad libitum on intake and immunoglobulin levels in dairy calves
Authors: Collings L. K. M. , Proudfoot K. L. , Veira D. M.
Published: March 2011

Collings, L. K. M., Proudfoot, K. L. and Veira, D. M. 2011. The effects of feeding untreated and formic acid treated colostrum ad libitum on intake and immunoglobulin levels in dairy calves. Can. J. Anim. Sci. 91: 55–59. Newborn dairy bull calves were fed 4 L of colostrum by esophageal feeder or offered untreated or formic acid-treated colostrum ad libitum for 24 h; effects on intake, serum immunoglobulin G (IgG) levels and behavior were measured. The untreated ad libitum group consumed more colostrum (6 vs. 4 L) but had comparable serum IgG levels to the control (27.8 vs. 28.1 mg mL−1). Adding formic acid to colostrum successfully reduced total bacteria and coliform counts; however, it reduced 24 h ad libitum consumption. Formic acid is not a practical preservation agent for colostrum offered ad libitum to newborn calves.
Review: Effects of feeding sugars on productivity of lactating dairy cows
Authors: Oba Masahito
Published: March 2011

Oba, M. 2011. Review: Effects of feeding sugars on productivity of lactating dairy cows. Can. J. Anim. Sci. 91: 37–46. Sugars are water-soluble carbohydrates that are readily available in the rumen. Although sugars ferment faster than starch or fibre in the rumen, the rates of disaccharide hydrolysis and monosaccharide fermentation vary greatly depending on the type of sugar and rumen environment. Despite rapid fermentation in the rumen and their potential to provide greater fermentable energy to enhance microbial protein production, feeding sugars in place of dietary starch sources may not decrease rumen pH or improve N utilization efficiency and milk protein production in dairy cows. However, feeding high-sugar diets often increases dry matter intake, butyrate concentration in the rumen, and milk fat yield. These nutritional characteristics of sugars may allow us to use high-sugar feedstuffs as an alternative energy source for lactating dairy cows to increase dietary energy density with reduced risk of rumen acidosis, but there is little evidence in the literature to indicate that the synchrony of rumen fermentation would be enhanced by feeding high-sugar diets with high soluble protein. Greater butyrate production from feeding high-sugar diets is expected to enhance proliferation of gut tissues, but its physiological mechanisms and effects of butyrate metabolism on overall productivity of dairy cows warrant further investigations.
Inverse modelling of European N2O emissions: assimilating observations from different networks
Authors: Corazza M. , Bergamaschi P. , Vermeulen A. T. , Aalto T. , Haszpra L. , Meinhardt F. , O'Doherty S. , Thompson R. , Moncrieff J. , Popa E. , Steinbacher M. , Jordan A. , Dlugokencky E. , Brühl C. , Krol M. , Dentener F.
Published: March 2011

Abstract. We describe the setup and first results of an inverse modelling system for atmospheric N2O, based on a four-dimensional variational (4DVAR) technique and the atmospheric transport zoom model TM5. We focus in this study on the European domain, utilizing a comprehensive set of quasi-continuous measurements over Europe, complemented by N2O measurements from the Earth System Research Laboratory of the National Oceanic and Atmospheric Administration (NOAA/ESRL) cooperative global air sampling network. Despite ongoing measurement comparisons among networks parallel measurements at a limited number of stations show that significant offsets exist among the different laboratories. Since the spatial gradients of N2O mixing ratios are of the same order of magnitude as these biases, the direct use of these biased datasets would lead to significant errors in the derived emissions. Therefore, in order to also use measurements with unknown offsets, a new bias correction scheme has been implemented within the TM5-4DVAR inverse modelling system, thus allowing the simultaneous assimilation of observations from different networks. The N2O bias corrections determined in the TM5-4DVAR system agree within ~0.1 ppb (dry-air mole fraction) with the bias derived from the measurements at monitoring stations where parallel NOAA discrete air samples are available. The N2O emissions derived for the northwest European and east European countries for 2006 show good agreement with the bottom-up emission inventories reported to the United Nations Framework Convention on Climate Change (UNFCCC). Moreover, the inverse model can significantly narrow the uncertainty range reported in N2O emission inventories for these countries, while the lack of measurements does not allow to reduce the uncertainties of emission estimates in southern Europe. Several sensitivity experiments were performed to test the robustness of the results. It is shown that also inversions without detailed a priori spatio-temporal emission distributions are capable to reproduce major regional emission patterns within the footprint of the existing atmospheric network, demonstrating the strong constraints of the atmospheric observations on the derived emissions.
Concurrent observations of atomic iodine, molecular iodine and ultrafine particles in a coastal environment
Authors: Mahajan A. S. , Sorribas M. , Gómez Martín J. C. , MacDonald S. M. , Gil M. , Plane J. M. C. , Saiz-Lopez A.
Published: March 2011

Abstract. Simultaneous measurements of atomic iodine (I), molecular iodine (I2) and ultrafine particles were made at O Grove, Galicia (42.50° N, 8.87° W), on the northwest coast of Spain. The observations show a strong tidal signature, and indicate that the most probable sources of reactive iodine species are the exposed macroalgae during low tide. For the first time, I2 and I were concurrently measured revealing a high average I2/I ratio of ~32, which is higher than previously inferred by modelling studies. A 1-dimensional photochemical model is employed to simulate the observations showing that the high I2/I ratio can be reproduced in the presence of fast vertical mixing close to the surface, or using an extra chemical loss for I atoms with an unknown species. There is a lack of strong correlation between the I2/I and ultrafine particles, indicating that although they both have macroalgal sources, these were not at the same location. The model simulations also suggest that the source of the observed ultrafine particles is likely not very close to the measurement site, in order for the particles to form and grow, but the source for I and I2 must be local. Finally, the effect of NOx levels on iodine oxides, and the conditions under which iodine particle bursts will be suppressed, are explored.
Quantifying nitrate dynamics in an oligotrophic lake using Δ17O
Authors: Tsunogai U. , Daita S. , Komatsu D. D. , Nakagawa F. , Tanaka A.
Published: March 2011

Abstract. The stable isotopic compositions of nitrate, including the 17O anomalies (Δ17O), were determined twice in 1 yr (June and August 2007) in the oligotrophic water column of Lake Mashu, Japan. These data were then used to quantify the geochemical dynamics of nitrate in the lake, by using the deposition rate of the atmospheric nitrate onto the entire catchment area of the lake. The total amount of nitrate in the lake water decreased from 4.2 to 2.1 Mmol during the period between the observations, while the average Δ17O values remained uniform at +2.5‰. The Δ17O values corresponded to an small and uniform mixing ratio of atmospheric nitrate to total nitrate of 9.7 ± 0.8%. These results indicate that 0.52 ± 0.34 Mmol of the remineralized nitrate was fed into the water column through nitrification, while 2.6 ± 0.4 Mmol of nitrate was simultaneously removed from the water column by assimilation, during the period between the observations. The lake water dissolved nitrate was characterized by rapid removal through assimilation during summer until it was almost completely removed from the euphotic layer, as well as continuous feeding into the lake through nitrification (3.2 ± 0.3 Mmol a−1) and deposition (0.35 ± 0.2 Mmol a−1), regardless of the seasons. The 15N-depleted nitrogen isotopic compositions of nitrate were as low as −6.5‰ in June, which also indicates that in-lake nitrification is the major source of nitrate in the lake and suggests that there is low potential for denitrification in and around the lake. Atmospheric nitrate deposited into the lake will be assimilated quickly, having a mean residence time of 1.2 ± 0.1 yr. In addition, more than 90% of the assimilated nitrate will be remineralized to nitrate and re-assimilated via active nitrogen cycling in the lake.
Stable water isotopes of precipitation and firn cores from the northern Antarctic Peninsula region as a proxy for climate reconstruction
Authors: Fernandoy F. , Meyer H. , Tonelli M.
Published: March 2011

Abstract. In order to investigate the climate variability in the north Antarctic Peninsula region, this paper focuses on the relationship between stable isotope content of precipitation and firn, and main meteorological variables (air temperature, relative humidity, sea surface temperature, and sea ice extent). Between 2008 and 2010, we collected precipitation samples and retrieved firn cores from several key sites in this region. We conclude that the deuterium excess oscillation represents a robust indicator of the meteorological variability on a seasonal to sub-seasonal scale. Low absolute deuterium excess values and the synchronous variation of both deuterium excess and air temperature imply that the evaporation of moisture occurs in the adjacent Southern Ocean. The δ18O–air temperature relationship is complicated and significant only at a (multi) seasonal scale. Backward trajectory calculations show that air-parcels arriving at the region during precipitation events predominantly originate at the South Pacific Ocean and Bellingshausen Sea. These investigations will be used as a calibration for on-going and future research in the area, suggesting that appropriate locations are located above 600 m a.s.l. We selected the Plateau Laclavere, Antarctic Peninsula as the most promising site for a deeper drilling campaign.
Rapid Room‐Temperature Synthesis of Metal–Organic Framework HKUST‐1 Crystals in Bulk and as Oriented and Patterned Thin Films
Authors: Zhuang Jin‐Liang , Ceglarek Doris , Pethuraj Sangeetha , Terfort Andreas
Published: March 2011

Whereas the preparation of defined metal–organic framework (MOF) materials via hydrothermal or diffusion methods typically requires hours to days, our simple precipitation route opens the access to the well‐known HKUST‐1 frameworks within minutes. Crucial for the formation of a well‐defined, crystalline material is the choice of suitable precipitating solvents, with methanol and ethanol being the most favorable ones. This approach could be extended to the formation of dense, surface‐mounted MOF films (so‐called SURMOFs), in particular if the surfaces are decorated with suitable binding groups by formation of self‐assembled monolayers (SAMs). By combination with micro‐contact printing (μCP), patterned SURMOFs became accessible, in which the precipitating solvent is decisive on the formation of either spatially restricted films or single particles.
Automatic differentiation‐based quadrature method of moments for solving population balance equations
Authors: Kariwala Vinay , Cao Yi , K. Nagy Zoltan
Published: March 2011

The quadrature method of moments (QMOM) is a promising tool for the solution of population balance equations. QMOM requires solving differential algebraic equations (DAEs) consisting of ordinary differential equations related to the evolution of moments and nonlinear algebraic equations resulting from the quadrature approximation of moments. The available techniques for QMOM are computationally expensive and are able to solve for only a few moments due to numerical robustness deficiencies. In this article, the use of automatic differentiation (AD) is proposed for solution of DAEs arising in QMOM. In the proposed method, the variables of interest are approximated using high‐order Taylor series. The use of AD and Taylor series gives rise to algebraic equations, which can be solved sequentially to obtain high‐fidelity solution of the DAEs. Benchmark examples involving different mechanisms are used to demonstrate the superior accuracy, computational advantage, and robustness of AD‐QMOM over the existing state‐of‐the‐art technique, that is, DAE‐QMOM. © 2011 American Institute of Chemical Engineers AIChE J, 2012
Measurements and computation of low mass transfer coefficients for FCC particles with ozone decomposition reaction
Authors: Kashyap Mayank , Gidaspow Dimitri
Published: March 2011

The mass transfer coefficients and Sherwood numbers for catalyzed fluid cracking catalyst particles were measured and computed in a two‐dimensional (2‐D) bubbling fluidized bed, with ozone decomposition reaction. The measured and computed Sherwood numbers, using 3‐ and 2‐D kinetic theory based computational fluid dynamics simulations, were of the order of 10−6–10−2. The low Sherwood numbers were in reasonable agreement with the literature data for small particles, at low Reynolds numbers. The computational fluid dynamics simulations showed that it is possible to compute conversions in fluidized bed reactors without using the conventional model with empirical mass transfer coefficients. © 2011 American Institute of Chemical Engineers AIChE J, 2012
Collagenous Skeleton of the Rat Mystacial Pad
Authors: Haidarliu Sebastian , Simony Erez , Golomb David , Ahissar Ehud
Published: March 2011

Anatomical and functional integrity of the rat mystacial pad (MP) is dependent on the intrinsic organization of its extracellular matrix. By using collagen autofluorescence, in the rat MP, we revealed a collagenous skeleton that interconnects whisker follicles, corium, and deep collagen layers. We suggest that this skeleton supports MP tissues, mediates force transmission from muscles to whiskers, facilitates whisker retraction after protraction, and limits MP extensibility. Anat Rec, 2011. © 2011 Wiley‐Liss, Inc.
Logistic risk model for mortality following elective abdominal aortic aneurysm repair
Authors: Grant S W , Grayson A D , Purkayastha D , Wilson S D , McCollum C
Published: March 2011

Background

The aim was to develop a multivariable risk prediction model for 30-day mortality following elective abdominal aortic aneurysm (AAA) repair.

Methods

Data collected prospectively on 2765 consecutive patients undergoing elective open and endovascular AAA repair from September 1999 to October 2009 in the North West of England were split randomly into development (1936 patients) and validation (829) data sets. Logistic regression analysis was undertaken to identify risk factors for 30-day mortality.

Results

Ninety-eight deaths (5·1 per cent) were recorded in the development data set. Variables associated with 30-day mortality included: increasing age (P = 0·005), female sex (P = 0·002), diabetes (P = 0·029), raised serum creatinine level (P = 0·006), respiratory disease (P = 0·031), antiplatelet medication (P < 0·001) and open surgery (P = 0·002). The area under the receiver operating characteristic (ROC) curve for predicted probability of 30-day mortality in the development and validation data sets was 0·73 and 0·70 respectively. Observed versus expected 30-day mortality was 3·2 versus 2·0 per cent (P = 0·272) in low-risk, 6·1 versus 5·1 per cent (P = 0·671) in medium-risk and 11·1 versus 10·7 per cent (P = 0·879) in high-risk patients.

Conclusion

This multivariable model for predicting 30-day mortality following elective AAA repair can be used clinically to calculate patient-specific risk and is useful for case-mix adjustment. The model predicted well across all risk groups in the validation data set.
Development and validation of high‐performance liquid chromatography/electrospray ionization mass spectrometry for assay of madecassoside in rat plasma and its application to pharmacokinetic study
Authors: Han Wen‐Jing , Xia Yu‐Feng , Dai Yue
Published: March 2011

A rapid, sensitive and specific high‐performance liquid chromatography/electrospray ionization mass spectrometric (LC‐ESI‐MS) method was developed and validated for the quantification of madecassoside, a major active constituent of Centella asiatica (L.) Urb. herbs, in rat plasma. With paeoniflorin as an internal standard (IS), a simple liquid–liquid extraction process was employed for the plasma sample preparation. Chromatographic separation was achieved within 6 min on a Shim‐pack CLC‐ODS column using acetonitrile and water (60:40, v/v) containing 0.1% (v/v) formic acid as the mobile phase. The detection was performed by MS with electrospray ionization interface in negative selected ion monitoring (SIM) mode. The linear range was 11–5500 ng/mL with the square regression coefficient (r2) of 0.9995. The lower limit of quantification was 11 ng/mL. The intra‐ and inter‐ day precision ranged from 4.99 to 9.03%, and the accuracy was between 95.82 and 111.80%. The average recoveries of madecassoside and IS from spiked plasma samples were >92%. The developed method was successfully applied to the pharmacokinetic study of madecassoside in rats after an oral administration. Copyright © 2011 John Wiley & Sons, Ltd.
Palladium‐Catalyzed Direct Benzylation of Xanthines
Authors: Sahnoun Sophian , Messaoudi Samir , Brion Jean‐Daniel , Alami Mouâd
Published: March 2011

An efficient and versatile synthetic palladium‐catalyzed sp2 CH bond activation approach for the preparation of a series of C8‐benzyl xanthines has been developed using benzyl chlorides as coupling partners. The reactions take place rapidly in 1,4‐dioxane and proceed in the presence of [PdCl2(MeCN)2]/P(o‐tolyl)3 as a catalyst system and Cs2CO3 as a base to afford good to excellent yields of the corresponding C8‐benzylated xanthines of biological interest.
A Heme–Peptide Metalloenzyme Mimetic with Natural Peroxidase‐Like Activity
Authors: Nastri Flavia , Lista Liliana , Ringhieri Paola , Vitale Rosa , Faiella Marina , Andreozzi Concetta , Travascio Paola , Maglio Ornella , Lombardi Angela , Pavone Vincenzo
Published: March 2011

Mimicking enzymes with alternative molecules represents an important objective in synthetic biology, aimed to obtain new chemical entities for specific applications. This objective is hampered by the large size and complexity of enzymes. The manipulation of their structures often leads to a reduction of enzyme activity. Herein, we describe the spectroscopic and functional characterization of FeIII–mimochrome VI, a 3.5 kDa synthetic heme–protein model, which displays a peroxidase‐like catalytic activity. By the use of hydrogen peroxide, FeIII–mimochrome VI efficiently catalyzes the oxidation of several substrates, with a typical Michaelis–Menten mechanism and with several multiple turnovers. The catalytic efficiency of FeIII–mimochrome VI in the oxidation of 2,2′‐azino‐di(3‐ethyl‐benzothiazoline‐6‐sulfonic acid (ABTS) and guaiacol (kcat/Km=4417 and 870 mM−1 s−1, respectively) is comparable to that of native horseradish peroxidase (HRP, kcat/Km=5125 and 500 mM−1 s−1, respectively). FeIII–mimochrome VI also converts phenol to 4‐ and 2‐nitrophenol in the presence of NO2− and H2O2 in high yields. These results demonstrate that small synthetic peptides can impart high enzyme activities to metal cofactors, and anticipate the possibility of constructing new biocatalysts tailored to specific functions.
A Series of Tripodal Cysteine Derivatives as Water‐Soluble Chelators that are Highly Selective for Copper(I)
Authors: Pujol Anaïs M. , Gateau Christelle , Lebrun Colette , Delangle Pascale
Published: March 2011

A series of tripodal ligands derived from nitrilotriacetic acid and extended by three converging, metal‐binding, cysteine chains was synthesised. Their ability to bind soft metal ions thanks to their three thiolate functions was investigated by means of complementary analytical and spectroscopic methods. Three ligands that differ by the nature of the carbonyl group next to the coordinating thiolate functions were studied: L1 (ester), L2 (amide) and L3 (carboxylate). The negatively charged derivative L3, which bears three carboxylate functions close to the metal binding site, gives polynuclear copper(I) complexes of low stability. In contrast, the ester and amide derivatives L1 and L2 are efficient CuI chelators with very high affinities, close to that reported for the metal‐sequestering metallothioneins (log K≈19). Interestingly, these two ligands form mononuclear copper complexes with a unique MS3 coordination in water solution. An intramolecular hydrogen‐bond network involving the amide functions in the upper cavity of the tripodal ligands stabilises these mononuclear complexes and was evidenced by the very low chemical‐shift temperature coefficient of the secondary amide protons. Moreover, L1 and L2 display large selectivities for the targeted metal ion that is, CuI, with respect to bioavailable ZnII. Therefore the two sulfur‐based tripods L1 and L2 are of potential interest for intracellular copper detoxication in vivo, without altering the homeostasis of the essential metal ion ZnII.
ChemInform Abstract: CsAlZr2(PO4)4: An Anhydrous Aluminum Zirconium Phosphate with a Novel Three‐Dimensional Framework.
Authors: Zhao Dan , Li Fei‐Fei , Zhang Ai‐Yun , Yang Lei , Zhu Rui
Published: March 2011

Single crystals of the title compound are grown from mixture of Cs2CO3, Al2O3, ZrO2, and NH4H2PO4 with a Cs:Al:Zr:P molar ratio of 1.66:1:1:8 (Pt crucible, 1173 K, 20 h).
ChemInform Abstract: Structural Evolution of Magnesium Difluoride: From an Amorphous Deposit to a New Polymorph.
Authors: Bach Andreas , Fischer Dieter , Mu Xiaoke , Sigle Wilfried , van Aken Peter A. , Jansen Martin
Published: March 2011

Amorphous samples of MgF2 are deposited on substrates below ‐100 °C and the structural transformations occurring upon warming are monitored by in situ powder XRD and TEM.
ChemInform Abstract: Magnetic Properties and Magnetocaloric Effect in GdCo3B2 Compound.
Authors: Li Lingwei , Nishimura Katsuhiko , Igawa Hiroto , Huo Dexuan
Published: March 2011

The title compound is prepared by arc melting of stoichiometric amounts of the elements followed by annealing at 1073 K for one week.
ChemInform Abstract: Preparation and Characterization of La1‐xKxFeO3 (x = 0—1) by self‐Propagating High‐Temperature Synthesis for Use as Soot Combustion Catalyst.
Authors: Taniguchi Keita , Okinaka Noriyuki , Akiyama Tomohiro
Published: March 2011

The potassium‐substituted LaFeO3 title perovskites are prepared by self‐propagating high‐temperature synthesis from mixtures of La2O3, K2CO3, Fe, and NaClO4 which are ignited using an electrically heated carbon foil.
ChemInform Abstract: Mn—Zn Soft Magnetic Ferrite Nanoparticles Synthesized from Spent Alkaline Zn—Mn Batteries.
Authors: Hu Ping , Pan De'an , Zhang Shengen , Tian Jianjun , Volinsky Alex A.
Published: March 2011

Mn0.5Zn0.5Fe2O4 nanoparticles are prepared using spent alkaline batteries as raw materials by a multi‐step process including acid leaching, chemical treatment of iron shells, and citrate—nitrate precursor auto‐combustion.
ChemInform Abstract: Superparamagnetic Nanoparticle‐Supported (S)‐Diphenylprolinol Trimethylsilyl Ether as a Recyclable Catalyst for Asymmetric Michael Addition in Water.
Authors: Wang Bang Gen , Ma Bao Chun , Wang Qiong , Wang Wei
Published: March 2011

The catalyst can be easily recovered and used for four times with decreasing yields but without significant loss in selectivity.
ChemInform Abstract: Catalytic Hydroalkoxylation of Alkenes by Iron(III) Catalyst.
Authors: Ke Fang , Li Zhengkai , Xiang Haifeng , Zhou Xiangge
Published: March 2011

An efficient method for the Markovnikov‐type addition of alcohols to mono‐substituted olefins is developed using FeCl3 as an inexpensive catalyst.
ChemInform Abstract: Synthesis and Biological Activity Test of Some New Five Membered Heterocycles.
Authors: Xia Qingchun , Xu Dongfang , He Qizhuang , Li Xingyu , Sun Dazhi
Published: March 2011

All synthesized compounds are screened for their in vitro antimicrobial activity against E.
ChemInform Abstract: Cobalt Carbaporphyrin‐Catalyzed Cyclopropanation.
Authors: Fields Kimberly B. , Engle James T. , Sripothongnak Saovalak , Kim Chungsik , Zhang X. Peter , Ziegler Christopher J.
Published: March 2011

Cobalt carbaporphyrinoids catalyze the cyclopropanation of styrene with a higher trans‐selectivity than the corresponding porphyrin and phthalocyanine complexes.
ChemInform Abstract: Synthesis of Amino Acid Derived Enaminones via Wolff Rearrangement Using Vinylogous Amides as Carbon Nucleophiles.
Authors: Seki Hajime , Georg Gunda I.
Published: March 2011

Diazoketones derived from amino acids are converted into monocyclic, bicyclic, and tricyclic enaminones via Wolff rearrangement.
ChemInform Abstract: Domino Gold‐Catalyzed Rearrangement and Fluorination of Propargyl Acetates.
Authors: De Haro Teresa , Nevado Cristina
Published: March 2011

An efficient method for the synthesis of α‐fluoroenones (II) is elaborated using a gold‐catalyzed rearrangement of propargyl acetates (I) in the presence of a fluorination agent.
ChemInform Abstract: Visible‐Light Photoredox Catalysis: Dehalogenation of Vicinal Dibromo‐, α‐Halo‐, and α,α‐Dibromocarbonyl Compounds.
Authors: Maji Tapan , Karmakar Ananta , Reiser Oliver
Published: March 2011

In the presence of RuCl2(bipy)3, ascorbic acid, 1,5‐dimethoxynaphthalene, and visible light the title compounds undergo mild and efficient dehalogenation to afford alkenes, alkynes, monobromides, and ketones.
ChemInform Abstract: (Bromodimethyl)sulfonium Bromide‐Mediated Thiolysis of Epoxides: An Easy Access to β‐Hydroxy Sulfides and Benzoxathiepinones in Solvent‐Free Conditions.
Authors: Shailaja M. , Manjula A. , Rao B. Vittal
Published: March 2011

The title sulfonium bromide efficiently promotes the thiolysis of epoxides producing β‐hydroxy sulfides in excellent yields and short reaction times.
ChemInform Abstract: A Multiligand Based Pd Catalyst for C—N Cross‐Coupling Reactions.
Authors: Fors Brett P. , Buchwald Stephen L.
Published: March 2011

A palladium catalyst based on two different biarylphosphine ligands (BrettPhos and RuPhos) is shown to not only encompass the substrate scope and activity of each ligand alone but also manifests its own reactivity.
ChemInform Abstract: An Eco‐Sustainable Erbium(III) Triflate Catalyzed Formation and Cleavage of tert‐Butyl Ethers.
Authors: Procopio Antonio , Costanzo Paola , Curini Massimo , Nardi Monica , Oliverio Manuela , Paonessa Rosina
Published: March 2011

Er(OTf)3 is found to be an efficient catalyst for the formation of tert‐butyl ethers from aliphatic alcohols and phenols under mild solvent‐free conditions.
ChemInform Abstract: Regioselective Cobalt‐Catalyzed Alder‐ene Reaction Toward Silicon‐ and Boron‐Functionalized Building Blocks.
Authors: Hilt Gerhard , Erver Florian , Harms Klaus
Published: March 2011

The title reaction is used in many reactions for the preparation of the target compounds They are mainly formed as (E) or (Z) isomers, respectively.
ChemInform Abstract: Synthesis and Reactivity of β,γ‐Dihalogenated Unsaturated Acids: Application to the Synthesis of 4‐Substituted 5H‐Furan‐2‐ones.
Authors: Lamande‐Langle S. , Ngi S. Inack , Anselmi E. , Allouchi H. , Duchene A. , Abarbri M. , Thibonnet J.
Published: March 2011

Direct halogenation of butadienoic acid affords E/Z‐mixtures of β,γ‐dihalogenated unsaturated acids.
ChemInform Abstract: Efficient Solvent‐Free Synthesis of Urea Derivatives Using Selenium‐Catalyzed Carbonylation of Amines with Carbon Monoxides and Oxygen.
Authors: Mizuno Takumi , Nakai Takeo , Mihara Masatoshi
Published: March 2011

A Se‐catalyzed carbonylation/oxidation sequence allows the conversion of diamines, primary and secondary amines into the corresponding urea derivatives.
ChemInform Abstract: Asymmetric Cyclopropanation of β,γ‐Unsaturated α‐Ketoesters with Stabilized Sulfur Ylides Catalyzed by C2‐Symmetric Ureas.
Authors: Cheng Ying , An Jing , Lu Liang‐Qiu , Luo Lan , Wang Zheng‐Yi , Chen Jia‐Rong , Xiao Wen‐Jing
Published: March 2011

In the presence of URE, ketoesters of type (I) efficiently undergo coupling with sulfur ylides like (II) to afford 1,2,3‐trisubstituted cyclopropanes with moderate to good diastereo‐ and enantioselectivity.
ChemInform Abstract: Versatile Method for the Synthesis of 4‐Aminocyclopentenones: Dysprosium (III) Triflate Catalyzed Aza‐Piancatelli Rearrangement.
Authors: Veits Gesine K. , Wenz Donald R. , Read de Alaniz Javier
Published: March 2011

The aza‐Piancatelli rearrangement affords a single trans diastereomer from both aryl‐ and alkyl‐substituted furylcarbinols.
ChemInform Abstract: Cross‐Coupling Reactions of Two Different Activated Alkenes Through Tetrabutylammonium Fluoride (TBAF) Promoted Deprotonation/Activation Strategy: A Regioselective Construction of Quaternary Carbon Centers.
Authors: Zhang Jing‐Li , Gong Yue‐Fa
Published: March 2011

Optimized conditions allow the preparation of most target compounds within a short time.
ChemInform Abstract: Copper‐Catalyzed Hydroxylation of Aryl Halides with Tetrabutylammonium Hydroxide: Synthesis of Substituted Phenols and Alkyl Aryl Ethers.
Authors: Paul Rajesh , Ali M. A. , Punniyamurthy Tharmalingam
Published: March 2011

Treatment of aryl halides under conditions A) results in the efficient formation of phenols.
ChemInform Abstract: Asymmetric Iron‐Catalyzed Hydrosilane Reduction of Ketones: Effect of Zinc Metal upon the Absolute Configuration.
Authors: Inagaki Tomohiko , Ito Akihiro , Ito Jun‐ichi , Nishiyama Hisao
Published: March 2011

The (S,S)‐BOPA/FeCl2 complex (II) is activated in the presence of Zn and affords the (S)‐configurated alcohol.
ChemInform Abstract: Enantioselective Ring Opening Reaction of meso‐Epoxides with Aromatic and Aliphatic Amines Catalyzed by Magnesium Complexes of BINOL Derivatives.
Authors: Bao Hongli , Wu Jiang , Li Hongji , Wang Zheng , You Tianpa , Ding Kuiling
Published: March 2011

The reaction with anilines is catalyzed by the (R)‐BINOL/Bu2Mg/MeLi system and tolerates a wide range of functional groups [cf.
ChemInform Abstract: Azetidine‐Derived Bifunctional Organocatalysts for Michael Reactions.
Authors: Menguy Laurence , Couty Francois
Published: March 2011

An aminomethylazetidine derivative generates, on reaction with aryl isothiocyanate, a bifunctional thiourea which smoothly catalyzes the asymmetric Michael addition of β‐dicarbonyl compounds with β‐nitrostyrenes ( up to 86% e.e.).
ChemInform Abstract: Lewis Acid‐Catalyzed Isomerization of 2‐Arylcyclopropane‐1,1‐dicarboxylates: A New Efficient Route to 2‐Styrylmalonates.
Authors: Chagarovskiy Alexey O. , Ivanova Olga A. , Rakhmankulov Eduard R. , Budynina Ekaterina M. , Trushkov Igor V. , Melnikov Mikhail Ya.
Published: March 2011

The isomerizations proceed chemo‐, regio‐ and stereoselectively to give (E)‐styrylmalonates and heterocyclic analogues.
ChemInform Abstract: Formamide as an Ammonia Synthon in Amination of Acid Chlorides.
Authors: Srinivasan S. , Manisankar P.
Published: March 2011

For the first time formamide is used as convenient source of ammonia in the direct conversion of acid chlorides to primary amides.
ChemInform Abstract: Chiral Calcium Organophosphate Catalyzed Enantioselective Electrophilic Amination of Enamides.
Authors: Drouet Fleur , Lalli Claudia , Liu Hua , Masson Geraldine , Zhu Jieping
Published: March 2011

Direct amination of the (E)‐enamides followed by in situ hydrolysis or reduction leads to formation of 2‐hydrazinoketones or syn‐1,2‐disubstituted 1,2‐diamines.
ChemInform Abstract: Rhenium Complex as a Useful Catalyst for Acylative Cleavage of Ethers.
Authors: Umeda Rui , Kaiba Kenta , Tanaka Toshimasa , Takahashi Yuuki , Nishimura Takashi , Nishiyama Yutaka
Published: March 2011

The Re‐catalyzed acylative cleavage of the C—O bond of ethers with acyl chlorides produces the corresponding esters in good yields.
ChemInform Abstract: Geometry‐Selective Synthesis of (E) or (Z) N‐Vinyl Ureas (N‐Carbamoyl Enamines).
Authors: Lefranc Julien , Tetlow Daniel J. , Donnard Morgan , Minassi Alberto , Galvez Erik , Clayden Jonathan
Published: March 2011

Starting from acetophenone substrates, 1,1‐disubstituted vinylureas of type (VI) and (VIII) are generated with moderate yields via N‐methyl imines [cf.
ChemInform Abstract: Synthesis of Benzodiquinanes via Tandem Palladium‐Catalyzed Semipinacol Rearrangement and Direct Arylation.
Authors: Schweinitz Angelika , Chtchemelinine Andrei , Orellana Arturo
Published: March 2011

The process renders possible an easy access to the rare tricyclic skeleton and tolerates various substituents at the aryl rings.
ChemInform Abstract: Chiral Primary Amine Catalyzed Asymmetric Epoxidation of α‐Substituted Acroleins.
Authors: Li Jiuyuan , Fu Niankai , Zhang Long , Zhou Pengxin , Luo Sanzhong , Cheng Jin‐Pei
Published: March 2011

The reaction is limited to α‐benzyl or alkyl‐substituted substrates.
ChemInform Abstract: Synthesis of Functionalized Dihydrothiophenes from Doubly Activated Cyclopropanes Using Tetrathiomolybdate as the Sulfur Transfer Reagent.
Authors: Gopinath Purushothaman , Chandrasekaran Srinivasan
Published: March 2011

A simple approach to various 2‐amino‐4,5‐dihydrothiophenes is reported.
ChemInform Abstract: Palladium‐Catalyzed Asymmetric Benzylation of 3‐Aryl Oxindoles.
Authors: Trost Barry M. , Czabaniuk Lara C.
Published: March 2011

Asymmetric benzylation of 3‐aryloxindoles (I) proceeds with good enantioselectivity (up to 96% e.e.) in the presence of a Pd—chiral bisphosphine catalyst to give oxindoles containing a quaternary all‐carbon stereocenter at position 3 (III) and (V).
ChemInform Abstract: Highly Efficient InBr3 Catalyzed Michael Addition of Indoles to α,β‐Unsaturated Esters.
Authors: Liu Ping , Chen Wei , Ren Kai , Wang Lei
Published: March 2011

The title method proceeds under safe and mild experimental conditions and offers important motifs for the synthesis of 3‐substituted indoles, e.g. as natural products.
ChemInform Abstract: Regiocontrolled Synthesis of Ring‐Fused Thieno[2,3‐c]pyrazoles Through 1,3‐Dipolar Cycloaddition of Nitrile Imines with Sulfur‐Based Acetylenes.
Authors: Chandanshive Jay Zumbar , Bonini Bianca Flavia , Gentili Denis , Fochi Mariafrancesca , Bernardi Luca , Comes Franchini Mauro
Published: March 2011

The sulfur controls the regiochemistry of the reaction.
ChemInform Abstract: A Facile 1,3‐Dipolar Cycloaddition of Azomethine Ylides to 2‐Arylidene‐1,3‐indanediones: Synthesis of Dispiro‐Oxindolylpyrrolothiazoles and Their Antimycobacterial Evaluation.
Authors: Maheswari Shanmugavel Uma , Balamurugan Kamaraj , Perumal Subbu , Yogeeswari Perumal , Sriram Dharmarajan
Published: March 2011

Compound (IVg) exhibits the highest in vitro activity against Mycobacterium tuberculosis H37Rv (MTB) and is about 3.4 times more active than ciprofloxacin and 5.4 times more potent than ethambutol.
ChemInform Abstract: Identification of Two Novel VHR Phosphatase Inhibitors with Structure‐Based Virtual Screening.
Authors: Park Hwangseo , Jeon Jeong‐Yi , Jeong Dae‐Gwin , Ryu Seong Eon
Published: March 2011

Compounds (I) and (II) exhibit significant inhibitory activity against VHR phosphatase.
ChemInform Abstract: Molecular Diversity of Tonghaosu Analogues, Selective Oxidation of the exo‐Cyclic Double Bond of Spiroacetal Enol Ethers and Diastereoselective Synthesis of Spiro‐Pyranone.
Authors: Yin Biaolin , Lai Jinqiang , Zhang Zeren , Wu Yulin
Published: March 2011

A facile method for the synthesis of compounds (II) and (III) is developed.
ChemInform Abstract: Asymmetric Synthesis of cis‐3,4‐Disubstituted Chromans and Dihydrocoumarins via an Organocatalytic Michael Addition/Hemiacetalization Reaction.
Authors: Enders Dieter , Wang Chuan , Yang Xuena , Raabe Gerhard
Published: March 2011

Domino Michael addition—hemiacetalization reaction of aliphatic aldehydes with o‐(β‐nitrovinyl)phenols is efficiently catalyzed by a prolinol‐derived organocatalyst to give cis‐disubstituted chromanols (III)/(VII) in excellent yields and stereoselectivities.
ChemInform Abstract: Task Specific Onium Salt as Soluble Support in Multicomponent Synthesis of 4‐Aryl‐2‐amino‐3‐ethoxycarbonyl‐naphthopyrans.
Authors: Lu Cuifen , Zhang Li , Yang Guichun , Chen Zuxing
Published: March 2011

The compound (I) is employed successfully as soluble support for the synthesis of the naphthopyrans (IV).
ChemInform Abstract: Synthesis and Biological Evaluation of 2‐Aminoisonicotinic Acid Analogues as HIF‐1α Inhibitors.
Authors: Xia Yan , Won Misun , Kang Jung Eun , Park Song‐Kyu , Lee Kiho , Kim Hwan‐Mook , Lee Kyeong
Published: March 2011

A series of 2‐aminoisonicotinic acid derivatives such as (I) and (II) is synthesized and evaluated for their in vitro HIF‐1 inhibitory activity.
ChemInform Abstract: Facile Synthesis of 1‐(Isoquinolin‐1‐yl)ureas by Silver Triflate Catalyzed Tandem Reactions of 2‐Alkynylbenzaldoximes with Carbodiimides.
Authors: Ye Shengqing , Wang Huanhuan , Wu Jie
Published: March 2011

Tandem 6‐endo cyclization, [3+2] cycloaddition, and subsequent rearrangement are involved.
ChemInform Abstract: Sodium Acetate Catalyzed Multicomponent Cyclization of Aromatic Aldehydes, Acetone and Meldrum Acid.
Authors: An Lin , Yang Feng , Yao Rong , Yan Chaoguo
Published: March 2011

A diastereospecific, simple, and practical synthesis of the compounds (IV) is presented.
ChemInform Abstract: Design, Synthesis and SAR of Thienopyridines as Potent CHK1 Inhibitors.
Authors: Zhao Lianyun , Zhang Yingxin , Dai Chaoyang , Guzi Timothy , Wiswell Derek , Seghezzi Wolfgang , Parry David , Fischmann Thierry , Siddiqui M. Arshad
Published: March 2011

Rigidification of the conformation behavior of a known CHK1 inhibitor leads to a constraint core possessing a thienopyridine template.
ChemInform Abstract: Synthesis of 2‐Aryl‐4‐(R‐sulfanylmethyl)‐3‐methyl‐6,7‐dihydro‐2H‐pyrazolo [3,4‐d]pyridazin‐7‐ones.
Authors: Matiichuk V. S. , Potopnyk M. A. , Obushak N. D.
Published: March 2011

An efficient method for the synthesis of functionally substituted 2‐aryl‐6,7‐dihydro‐2H‐pyrazolo[3,4‐d]pyridazin‐7‐ones (28 examples) is developed.
ChemInform Abstract: Functionalization of (2S)‐Isopropyl‐5‐iodo‐2,3‐dihydro‐4(H)‐pyrimidin‐4‐ones by a Suzuki—Miyaura Cross‐Coupling Reaction Using Aryltrifluoroborate Salts: Convenient Enantioselective Preparation of α‐Substituted β‐Amino Acids.
Authors: Stefani Helio A. , Amaral Monica F. Z. J. , Reyes‐Rangel Gloria , Vargas‐Caporali Jorge , Juaristi Eusebio
Published: March 2011

A large variety of groups present in the potassium aryltrifluoroborates (‐CF3, ‐OMe, ‐SEt, ‐CN, ‐CHO, ‐Cl, ‐Cbz, ‐OH) are tolerated in the title reaction.
ChemInform Abstract: Regioselective Sonogashira Cross‐Coupling Reactions of 6‐Chloro‐2,8‐diiodo‐9‐THP‐9H‐purine with Alkyne Derivatives.
Authors: Ibrahim Nada , Chevot Franciane , Legraverend Michel
Published: March 2011

The titled purine diiodo purine derivative (II) is an interesting novel substrate for the preparation of 2‐alkynylated and 2,8‐dialkynylated purines via regioselective cross‐coupling reactions with alkynes.
ChemInform Abstract: Synthesis of Benzotriazine and Aryltriazene Derivatives Starting from 2‐Azidobenzonitrile Derivatives.
Authors: Nakhai Azadeh , Stensland Birgitta , Svensson Per H. , Bergman Jan
Published: March 2011

The reactions of 2‐azidobenzonitrile derivatives (I) with alkyl magnesium halides give benzotriazines in moderate yields accompanied by aminobenzonitriles (IV).
ChemInform Abstract: Synthesis and Spectroscopic Characterization Study of Some Cyclic‐Azodioxides.
Authors: Al‐Magmoy Mohammad A. Naser , Al‐Shamkhani Zeki A. Nasir , Essa Ali Hashem
Published: March 2011

The title compounds are white crystalline solids.
ChemInform Abstract: Synthesis of Macrocyclic Tetrazoles for Rapid Photoinduced Bioorthogonal 1,3‐Dipolar Cycloaddition Reactions.
Authors: Yu Zhipeng , Lim Reyna K. V. , Lin Qing
Published: March 2011

A series of structurally novel macrocyclic diphenyltetrazoles such as (III) or (IX) is prepared by inserting a bridge between the two flanking phenyl rings.
ChemInform Abstract: Expected and Unexpected Reactions of 1,3‐Benzothiazine Derivatives. Part 1. Ring Transformation of β‐Lactam‐Condensed 1,3‐Benzothiazines into 4,5‐Dihydro‐1,4‐benzothiazepines and Indolo‐1,4‐benzothiazepines.
Authors: Fodor Lajos , Csomos Peter , Holczbauer Tamas , Kalman Alajos , Csampai Antal , Sohar Pal
Published: March 2011

Treatment of readily prepared lactam‐fused benzothiazines (III) with a large excess of sodium methoxide in methanol unexpectedly gives indolo‐1,4‐benzothiazepines (V) instead of the expected 4,5‐dihydro‐1,4‐benzothiazepines (VI).
ChemInform Abstract: Gold‐Catalyzed Cycloisomerization Reactions of Boronated Enynes.
Authors: Lee Jack Chang Hung , Hall Dennis G.
Published: March 2011

A protocol for the Au‐catalyzed cycloisomerization of boronated enynes is developed.
ChemInform Abstract: Palladium‐Catalyzed Regio‐, Diastereo‐, and Enantioselective Allylic Alkylation of Acylsilanes with Monosubstituted Allyl Substrates.
Authors: Chen Jian‐Ping , Ding Chang‐Hua , Liu Wei , Hou Xue‐Long , Dai Li‐Xin
Published: March 2011

The method provides products with high regio‐, diastereo‐, and enantioselectivities.
ChemInform Abstract: Synthesis of Water‐Tolerant Indium Homoenolate in Aqueous Media and Its Application in the Synthesis of 1,4‐Dicarbonyl Compounds via Palladium‐Catalyzed Coupling with Acid Chloride.
Authors: Shen Zhi‐Liang , Goh Kelvin Kau Kiat , Cheong Hao‐Lun , Wong Colin Hong An , Lai Yin‐Chang , Yang Yong‐Sheng , Loh Teck‐Peng
Published: March 2011

The synthetic utility of the indium homoenolates (II) is demonstrated by the synthesis of 1,4‐dicarbonyl compounds which are not readily available by conventional methods.
ChemInform Abstract: Ixorapeptide I and Ixorapeptide II, Bioactive Peptides Isolated from Ixora coccinea.
Authors: Lee Chia‐Lin , Liao Yung‐Chih , Hwang Tsong‐Long , Wu Chin‐Chung , Chang Fang‐Rong , Wu Yang‐Chang
Published: March 2011

The Me‐OH extract of the tropical roadside plant exhibits significant anti‐platelet aggregation and anti‐inflammatory effects.
ChemInform Abstract: Synthesis of Stereoisomers of Cryptofolione 6′‐Mono‐ and 4′,6′‐Di‐O‐benzyl Ethers.
Authors: Sabitha Gowravaram , Bhaskar Vangala , Reddy S. Siva Sankara , Yadav J. S.
Published: March 2011

The synthesis of the title compounds (I) starts from commercially available L‐malic acid.
ChemInform Abstract: Discovery of New Azaindole‐Based PI3Kα Inhibitors: Apoptotic and Antiangiogenic Effect on Cancer Cells.
Authors: Hong Seunghee , Lee Soyoung , Kim Bomi , Lee Hyunseung , Hong Soon‐Sun , Hong Sungwoo
Published: March 2011

Among a variety of azaindoles the derivative (I) exhibits strong antiangiogenic effects on cancer cells.
ChemInform Abstract: The Novel Benzopyran Class of Selective Cyclooxygenase‐2‐ Inhibitors. Part 3. The Three Microdose Candidates.
Authors: Wang Jane L. , et al. et al.
Published: March 2011

Design, synthesis, SAR, and human half‐life data of a novel series of potent and selective COX‐2 inhibitors (I) based on the 2‐trifluoromethyl‐2H‐benzopyran‐3‐carboxylic acid scaffold are reported.
ChemInform Abstract: Novel TNF‐α Converting Enzyme (TACE) Inhibitors as Potential Treatment for Inflammatory Diseases.
Authors: Girijavallabhan Vinay M. , et al. et al.
Published: March 2011

A series of acetylene‐based hydantoin inhibitors of the TACE enzyme is obtained in a convergent manner.