bluuebunny/crossref_metadata_2025 huggingface dataset:
Anguish and fears about attitude towards Covid-19 vaccines: contrasts between yes and no vax
Authors: Zatti Alberto , Riva Nicoletta
Published: May 2022

The present research investigates the possible causes of resistance to vaccination against the COVID-19 virus. A significant percentage of different countries' populations is refractory to being vaccinated (i.e., in October 2021, in Italy, 20% aged 40–50 years old). A 92-item questionnaire was filled in by a sample of 613 subjects, of which 50.4% said they were against COVID-19 vaccines (63.1% female). Guided by the hypothesis that emotionality constitutes a basis of pre-reflective judgment, items relating to fear, anger and anguish were introduced in the survey. The subjects compiled the Difficulties in Emotional Regulation Scale. The differences between the means of the two samples evaluated with the Student test show that it is, above all, the underlying anguish that constitutes the primary discriminant between the two samples. No Vax mainly considers external the sources of anguish, while Yes Vax sources of anguish appear more internal. From this result an interpretation is advanced: it seems more difficult for No Vax to trust authority recommendations/obligations to get vaccinated because anguish is located just outside the one's body, where Authority dominates.
Sexual Function Following Treatment for Stress Urinary Incontinence with Bulk Injection Therapy and Mid-Urethral Sling Surgery
Authors: Latul Yani P. , Casteleijn Fenne M. , Zwolsman Sandra E. , Roovers Jan-Paul W.R.
Published: May 2022

Background

Peri-urethral bulking injections (PBI) gain popularity for the treatment of stress urinary incontinence (SUI), but – in contrast to mid-urethral sling (MUS) surgery – little is known about its impact on sexual function.

Methods

This was a secondary analysis of a prospective cohort study that included patients with moderate to severe SUI undergoing either MUS surgery or PBI with polydimethylsiloxane Urolastic (PDMS-U). The validated Dutch and English version of the ‘Pelvic Organ Prolapse and/or Urinary Incontinence Sexual Function Questionnaire – IUGA Revised’ (PISQ-IR) was used to assess sexual function at baseline, at 6 and 12 months of follow-up. For between-group analysis, differences in baseline characteristics were corrected using multivariate analysis of covariance.

Outcomes

The primary outcome was the PISQ-IR single summary score of sexually active (SA) women following both procedures, calculated by mean calculation. Secondary outcomes were the PISQ-IR subscale scores of SA and non-sexually active (NSA) women, the proportions of sexual activity and subjective improvement (‘Patient Global Impression of Improvement’ (PGI-I)).

Results

A total of 259 women (MUS: n = 146, PBI: n = 113) were included in this study. The PISQ-IR single summary score of SA women improved following both interventions (in the MUS group from 3.2 to 3.4 and in the PBI group from 3.0 to 3.3 after 12 months). After correcting for differences in baseline characteristics, the PISQ-IR summary score at 6 and 12 months was similar for both treatment groups. For SA women, condition-specific and condition-impact subscale scores significantly improved following both procedures.

Clinical implications

In treating SUI, PBI is inferior to MUS surgery. However, there is a need for less invasive strategies, especially for women who are unfit for surgery or have contraindications. Sexual function improves after PBI using PDMS-U, which is relevant for the counselling of women with SUI about available treatment options.

Strengths & limitations

Strength: until this study, there was a lack of knowledge about the effects of PBI on sexual function. Limitation: there may be indication bias as we did not perform a randomized controlled trial.

Conclusion

PBI using PMDS-U and MUS surgery for the treatment of SUI improve sexual function equally in SA women, mainly by decreasing the condition’s impact on sexual activity and quality.
Human Dignity in International Law
Authors: Le Moli Ginevra
Published: May 2022

Over the past two centuries, the concept of human dignity has moved from the fringes to the centre of the international legal system. This book is the first detailed historical, theoretical and legal investigation of human dignity as a normative value, the intellectual sources that shaped its legal recognition, and the main legal instruments used to give it expression in international law. Ginevra Le Moli addresses the broad historical and philosophical developments relating to the legal expression of dignity and the doctrinal geography of human dignity in international law, with a focus on international humanitarian law, international human rights law and international criminal law. The book fills a major lacuna in the literature by providing a comprehensive account of dignity within international law that draws on an extensive documentary and archival basis and a vast body of decisions of international judicial and quasi-judicial bodies.
The Risks of Trustworthy Artificial Intelligence: The Case of the European Travel Information and Authorisation System
Authors: Derave Charly , Genicot Nathan , Hetmanska Nina
Published: May 2022

In recent years, the European Union (EU) has strongly promoted a human-centric and trustworthy approach to artificial intelligence (AI). The 2021 proposal for a Regulation on AI that the EU seeks to establish as a global standard is the latest step in the matter. However, little attention has been paid to the EU’s use of AI to pursue its own purposes, despite its wide use of digital technologies, notably in the field of border management. Yet, such attention allows us to confront the highly moral discourse that characterises EU institutions’ communications and legislative acts with a concrete example of how the promoted values are realised “on the ground”. From this perspective, this paper takes the case study of the European Travel Information and Authorisation System (ETIAS), an EU information technology system (planned to become operational in May 2023) that will provide travel authorisation to visa-exempt third-country nationals using a profiling algorithm. The paper shows, on the one hand, that ETIAS constitutes another piece in the massive infrastructure of digital surveillance of third-country nationals that the EU has been building for years. On the other hand, ETIAS’s algorithmic process is shown to be an instrument of differential exclusion that could well have an adverse impact on certain groups of foreign travellers. Ultimately, this paper argues that far from falling outside the scope of the trustworthy approach to AI championed by the EU, ETIAS – and more broadly the systematic risk evaluation predominant in the EU’s use of AI – is a constitutive part of it.
The Trees of the Forest: Uncovering Small-Scale Producers in an Industrial District, 1781–1851
Authors: Lane Joe
Published: May 2022

This article uses trade directories and notifications in theLondon Gazetteto reconstruct the Potteries industrial district at the firm level for 1781 to 1851, a dynamic period of growth for a knowledge-intensive industry. It cuts across the organizational spectrum of the district in terms of the scale and scope of firms traditionally examined by including both the larger lead-firms and the smaller firms for which limited or no business records survive. It addresses difficulties associated with analysis of early clusters before the late nineteenth century. Directories offer a consistent series of records that, when cross-referenced with theGazetteand local newspapers, allow for detailed examination of firm behavior and the structure of the district during a formative growth period. Analysis highlights patterns of cooperative competition in an industry in which tacit knowledge played a crucial role as a source of competitive advantage, raises questions for future research, and provides an empirical base on which to consider further investigation of the trees that made up the forest.
How should we understand “bias” as a thick concept in recruitment discrimination studies?
Authors: Seppälä Päivi
Published: May 2022

Cesario criticizes the experimental design of studies of bias by claiming that acting on stereotypes in the experimental situation might not be an “error” from a Bayesian perspective. However, social psychologists might have an ethical reason to label the observed decision-maker biases as “erroneous.” Decision-making can be considered as “biased” and “erroneous,” because it reflects illegal and morally condemnable discrimination.
Two thousand years after Archimedes, psychologist finds three topics that will simply not yield to the experimental method
Authors: Payne B. Keith , Banaji Mahzarin R.
Published: May 2022

Cesario argues that experiments cannot illuminate real group disparities because they leave out factors that operate in ordinary life. But what Cesario calls flaws are, in fact, the point of the experimental method. Of all the topics in science, we have to wonder why racial discrimination would be uniquely unsuited for investigating with experiments. The argument to give up the most powerful scientific method to study one of the hardest problems we confront is laughable.
Reply to the commentaries: A radical revision of experimental social psychology is still needed
Authors: Cesario Joseph
Published: May 2022

Are the landscapes of real-world decisions adequately represented in our laboratory tasks? Are the goals and expertise of experimental participants the same as real-world decision-makers? Are we neglecting crucial forces that lead to group outcomes? Are the contingencies necessary for producing experimental demonstrations of bias present in the real world? In the target article, I argued that the answers to these questions are needed to understand whether and how laboratory research can inform real-world group disparities. Most of the commentaries defending experimental social psychology neglected to directly address these main arguments. The commentaries defending implicit bias only revealed the inadequacy of this concept for explaining group disparities. The major conclusions from the target article remain intact, suggesting that experimental social psychology must undergo major changes to contribute to our understanding of group disparities.
Resolving uncertainty in historical observations of the Adélie penguin breeding distribution in southern Prydz Bay, East Antarctica
Authors: Southwell Colin , Emmerson Louise
Published: May 2022

The sophisticated spatial reference tools that exist today greatly facilitate studies of spatial ecology. Historically, however, the lack of such tools meant that spatial data were often imprecise, ambiguous or sometimes inaccurate. This can hinder or confound assessments of whether species distributions have changed in the past over decadal timescales. This is the case for Adélie penguins breeding at the southern limit of their breeding range in East Antarctica. In this short note, we resolve uncertainties in the locations of Adélie penguin breeding sites observed in the first population survey in Prydz Bay in 1981 by examining the original working notes of that work in combination with data from a recent survey in 2009 and a recently published spatial reference and identification system for coastal East Antarctica. By clarifying the historical locations, we conclude that the Adélie penguin breeding distribution has remained unchanged in this region over the past three decades, and we provide a robust baseline for assessing change in the future.
Domain specificity of differential susceptibility: Testing an evolutionary theory of temperament in early childhood
Authors: Hentges Rochelle F. , Davies Patrick T. , Sturge-Apple Melissa L.
Published: May 2022

According to differential susceptibility theory (DST), some children may be more sensitive to both positive and negative features of the environment. However, research has generated a list of widely disparate temperamental traits that may reflect differential susceptibility to the environment. In addition, findings have implicated these temperament × environment interactions in predicting a wide variety of child outcomes. This study uses a novel evolutionary model of temperament to examine whether differential susceptibility operates in a domain-general or domain-specific manner. Using a racially and socioeconomically diverse sample of 243 preschoolers and their parents (56% female; 48% African American), we examined the interactions between maternal and paternal parenting quality and two evolutionary informed temperament profiles (i.e., Hawks and Doves) in predicting changes in teacher-reported conduct problems and depressive symptoms from preschool to first grade. Results suggest that differential susceptibility operates in a domain-specific fashion. Specifically, the “Hawk” temperament was differentially susceptible to maternal parenting in predicting externalizing problems. In contrast, the “Dove” temperament was susceptible to both paternal and maternal parenting quality in predicting changes in depressive symptoms. Findings provide support for an integrative framework that synthesizes DST with an evolutionary, function-based approach to temperament.
A distributionally ambiguous two-stage stochastic approach for investment in renewable generation
Authors: BORGES PEDRO , SAGASTIZÁBAL CLAUDIA , SOLODOV MIKHAIL , TOMASGARD ASGEIR
Published: May 2022

The optimal expansion of a power system with reduced carbon footprint entails dealing with uncertainty about the distribution of the random variables involved in the decision process. Optimisation under ambiguity sets provides a mechanism to suitably deal with such a setting. For two-stage stochastic linear programs, we propose a new model that is between the optimistic and pessimistic paradigms in distributionally robust stochastic optimisation. When using Wasserstein balls as ambiguity sets, the resulting optimisation problem has nonsmooth convex constraints depending on the number of scenarios and a bilinear objective function. We propose a decomposition method along scenarios that converges to a solution, provided a global optimisation solver for bilinear programs with polyhedral feasible sets is available. The solution procedure is applied to a case study on expansion of energy generation that takes into account sustainability goals for 2050 in Europe, under uncertain future market conditions.
Long-term results of the Warden procedure for right partial anomalous pulmonary venous connection
Authors: Dubost Clément , Pavy Carine , Maminirina Pierre , Benbrik Nadir , Baron Olivier
Published: May 2022

Introduction:

Surgery is considered as the first-line therapeutic strategy of partial anomalous pulmonary venous connection. The Warden technique has very good short-term results. The aim of this study is to evaluate the stability of these good results over a long period of follow-up.

Materials and Methods:

We reviewed all patients who underwent a Warden procedure for partial anomalous pulmonary venous connection between 1997 and 2017 in our centre. A total of 73 patients were included. The median age was 14 years (5 months–72 years). Post-operative data were obtained through our hospital network. Late follow-up data were obtained through referrals, cardiologist letters and directly from the patient.

Results:

The mean length of follow-up was 8 years and the longest time was 22 years (range, 1–22). Twenty-five percent of our cohort had more than 10 years of follow-up. There were no cardio-vascular deaths. Eight (11.6%) patients suffered from post-operative rhythm disturbances, 5 (7.2%) of which were permanent. Two (2.9%) patients required a pacemaker implantation. At the end of the follow-up period, only one patient remained pacemaker dependent. There were no pulmonary vein obstructions. Two (2.9%) caval vein stenosis were detected, one at 7 months and the other at 7 years. These patients were treated by angioplasty alone. Five (6.8%) patients were lost to follow-up.

Conclusions:

The good short-term results of the Warden procedure for right partial anomalous pulmonary venous connection appear to persist in the long term, with excellent freedom from pulmonary and caval stenosis in adolescence through to adulthood.
Etanercept with IVIg for acute Kawasaki disease: a long-term follow-up on the EATAK trial
Authors: Sagiv Eyal , Slee April , Buffone Ashley , Choueiter Nadine F. , Dahdah Nagib S. , Portman Michael A.
Published: May 2022

Background:

The Etanercept as Adjunctive Treatment for Acute Kawasaki Disease, a phase-3 clinical trial, showed that etanercept reduced the prevalence of IVIg resistance in acute Kawasaki disease. In patients who presented with coronary artery involvement, it reduced the maximal size and short-term progression of coronary artery dilation. Following up with this patient group, we evaluated the potential long-term benefit of etanercept for coronary disease.

Methods:

Patients were followed for at least 1 year after the trial. The size of dilated arteries (z-score ≥ 2.5) was measured at each follow-up visit. The z-score and size change from baseline were evaluated at each visit and compared between patients who received etanercept versus placebo at the initial trial.

Results:

Forty patients who received etanercept (22) or placebo (18) in the Etanercept as Adjunctive Treatment for Acute Kawasaki Disease trial were included. All patients showed a persistent decrease in coronary artery size measurement: 23.3 versus 5.9% at the 6-month visit, 24 versus 13.1% at the 1-year visit, and 20.8 versus 19.3% at the ≥ 2-year visit for etanercept or placebo, respectively, with similar results for decrease in coronary artery z-scores. In a multivariate analysis, correcting for patients’ growth, a greater size reduction for patients on the etanercept arm versus placebo was proved significant for the 6-month (p = 0.005) and the 1-year visits (p = 0.019) with a similar end outcome at the ≥ 2-year visit.

Discussion:

Primary adjunctive therapy with etanercept for children with acute Kawasaki disease does not change the end outcome of coronary artery disease but may promote earlier resolution of artery dilation.
Predicting the frequency of transgressive RILs and minimum population size required for their recovery in horse gram (Macrotyloma uniflorum (Lam.) Verdc)
Authors: Chandana B. R. , Ramesh S. , Kirankumar R. , Basanagouda G.
Published: May 2022

Early elimination of poor crosses based on an objective criterion allows increased allocation of resources only to a few promising crosses for identifying superior recombinant inbred lines (RILs) for use as pure-line cultivars in self-pollinated crops. Early generation (F2:3) prediction of frequency of superior RILs that could be derived from advanced generations of crosses is one such criterion. We predicted the frequency of transgressive RILs from two horse gram crosses (namely HPKM 320 × CRIDA18-R and IC 361290 × Palem 1) for primary branches per plant, pods per plant, pod weight per plant and grain weight per plant based on mid parental value, additive genetic effects and additive genetic variance estimated from trait means of parents, and their F2 and F2:3 generations. The predicted frequency of RILs that transgressed better parent/two checks varied with the cross and the trait within a cross. The frequencies of transgressive RILs predicted from IC 361290 × Palem 1 were higher than those predicted from HPKM 320 × CRIDA 18-R for three of the four traits. As expected, the minimum population size required to recover the transgressive RILs predicted from IC 361290 × Palem 1 was relatively smaller than that from IC 361290 × Palem 1. Increased allocation of resources for handling segregating populations derived from IC 361290 × Palem 1 is expected to result in superior RILs for use as cultivars. We believe that the objective criterion used in our study is handy in identifying superior RILs in early segregating populations derived from a few promising crosses.
Diapir Melting of Subducted Mélange Generating Alkaline Arc Magmatism and Its Implications for Material Recycling at Subduction Zone Settings
Authors: Wang Kai , Cai Keda , Sun Min , Wang Xiangsong , Xia Xiao‐Ping , Zhang Bo , Wan Bo
Published: May 2022

Alkaline rocks crop out in subduction‐related volcanic arcs globally, whose genesis is explained by partial melting of hybrid diapiric mélanges in the mantle wedge. Such a new model has not yet been evidenced by field‐based investigations, where mélanges and alkaline arc rocks have spatial‐temporal and genetic connections. In this study, we identified these two types of rock units exposed in Western Tianshan, and established their petrogenetic relationship through field, geochronologic, geochemical, and thermodynamic investigations. Our results suggest that partial melts produced by melting of the mélange matrix at pressures of 2.8–2.4 GPa and 1.8–1.4 GPa with temperatures of 1000–1200°C can replicate the major‐element contents and trace‐element abundances of the regional alkaline arc rocks. This finding not only supports the hypothesis that diapir melting of subducted mélanges has a capacity to generate alkaline arc magma, but also provides insight into material recycling at subduction zone settings.
Climatology and Seasonal Variations of Temperatures and Gravity Wave Activities in the Mesopause Region Above Ft. Collins, CO (40.6°N, 105.1°W)
Authors: She Chiao‐Yao , Yan Zhao‐Ai , Gardner Chester S. , Krueger David A. , Hu Xiong
Published: May 2022

Utilizing 956 nights of Na lidar nocturnal mesopause region temperature profiles acquired at Fort Collins, CO (40.6°N, 105.1°W) over a 20‐year period (March 1990–2010), we deduce background nightly mean temperature and the square of the buoyancy frequency N2(z) at 2‐km resolution between 83 and 105 km. The temperature climatology reveals the two‐level mesopause structure with clarity and sharp mesopause transitions, resulting in 102 days of summer from Days 121 to 222 of the year. The same data set analyzed at 10‐min and 1‐km resolution gives the gravity wave (GW) temperature perturbations Ti'(z) and the wave variance Var(T′(z)) and GW potential energy Epm(z) between 85 and 100 km. Seasonal averages of GW Var(T′(z)) and Epm(z) between 90 and 100 km, show that Var(T′) for spring and autumn are comparable and lower than for summer and winter. Due mainly to the higher background stability, or larger N2(z) in summer, Epm(z) between 85 and 100 km is comparable in spring, summer, and autumn seasons, but ∼30%–45% smaller than the winter values at the same altitude. The uncertainties are about 4% for winter and about 5% for the other three seasons. The values for Epm are (156.0, 176.2, 145.6, and 186.2 J/kg) at 85 km for (spring, summer, autumn, and winter) respectively, (125.4, 120.2, 115.2, and 168.7 J/kg) at 93 km, and (207.5, 180.5, 213.1, and 278.6 J/kg) at 100 km. Going up in altitude, all profiles first decrease and then increase, suggesting that climatologically, GWs break below 85 km.
Origin of Late Quaternary Gravel and Drainage Basin Expansion in the Northern Chinese Tian Shan: Insights From Sediment Provenance Analyses
Authors: Lu Honghua , Jiang Yutong , Li Bingjing , Pang Jianzhang , Wu Dengyun , Pang Lichen , Zheng Xiangmin , Li Youli
Published: May 2022

The source‐to‐sink relationship between a sedimentary basin and its adjacent mountain range is vital for understanding the genesis of piedmont coarse‐grained sediments and the evolution of mountain topography. By integrating zircon U‐Pb dating and heavy mineral assemblage analyses on 15 samples, this work focuses on the change of the provenance with time in the Urumqi River Neogene‐Pleistocene continental sequence in the northern Chinese Tian Shan foreland, which has been chronologically constrained to range from ∼6.8 to ∼0.55 Ma. The results of the integrated provenance analyses reveal two shifts in provenance during the periods of 4.6–2.5 and 0.9–0.55 Ma, yielding new zircon U‐Pb age signals from the glacier‐covered headwaters of the Urumqi River. These two identified provenance adjustments are causally related to enhanced glacial erosion in the high mountain. We propose that enhanced glacial erosion could have caused southward expansion of the Urumqi River drainage basin, increased production of coarse‐grained materials with new zircon U‐Pb age signals, and finally accumulation of piedmont alluvial gravel. The observed topographic and sedimentary responses to enhanced glaciation could have been common phenomena during the late Quaternary in alpine areas, where a large number of alluvial fans are widely distributed like aprons along the mountain front, as seen in the piedmonts of the Tian Shan in the arid interior of Asia.
High Free‐Tropospheric Aitken‐Mode Aerosol Concentrations Buffer Cloud Droplet Concentrations in Large‐Eddy Simulations of Precipitating Stratocumulus
Authors: Wyant Matthew C. , Bretherton Christopher S. , Wood Robert , Blossey Peter N. , McCoy Isabel L.
Published: May 2022

A new Aitken mode aerosol microphysics scheme is developed for a large eddy simulation model in order to better investigate cloud‐aerosol interactions in the marine boundary layer and to study the Aitken buffering hypothesis of McCoy et al. (2021), https://doi.org/10.1029/2020jd033529. This scheme extends the single‐mode two‐moment prognostic aerosol scheme of Berner et al. (2013), https://doi.org/10.5194/acp-13-12549-2013. Seven prognostic variables represent accumulation and Aitken log‐normal aerosol modes in air and droplets as well as 3 gas species. Scavenging of interstitial and other unactivated aerosol by cloud and rain drops are treated using the scheme described in Berner et al. (2013), https://doi.org/10.5194/acp-13-12549-2013. The scheme includes coagulation of unactivated aerosol and a simple chemistry model with gas phase H2SO4, SO2, and DMS as prognostic variables to capture basic influences of sulfur chemistry on the model aerosols. Nucleation of H2SO4 aerosol particles from gas‐phase H2SO4 is neglected. A deep, precipitating stratocumulus case (VAMOS Ocean Cloud Atmosphere Land Study RF06) is used to test the new scheme. The presence of the Aitken mode aerosol increases the cloud droplet concentration through activation of the larger Aitken particles and delays the creation of an ultraclean, strongly precipitating cumulus state. Scavenging of unactivated accumulation and Aitken particles by cloud and precipitation droplets accelerates the collapse. Increasing either the above‐inversion Aitken concentration or the surface Aitken flux increases the Aitken population in the boundary layer and prevents the transition to an ultraclean state.
Glacial Knowledge Gaps Impede Resilience to Sea Level Rise
Authors: Catania Ginny , Moon Twila , Aschwanden Andy
Published: May 2022

Changes to the support, culture, and community organization of U.S. glaciology are needed to advance understanding of glacial change and better predict rising seas and other ice loss impacts.
Blue LED-pumped intense short-wave infrared luminescence based on Cr3+-Yb3+-co-doped phosphors
Authors: Zhang Yan , Miao Shihai , Liang Yanjie , Liang Chao , Chen Dongxun , Shan Xihui , Sun Kangning , Wang Xiao-Jun
Published: May 2022

The growing demand for spectroscopy applications in the areas of agriculture, retail and healthcare has led to extensive research on infrared light sources. The ability of phosphors to absorb blue light from commercial LED and convert the excitation energy into long-wavelength infrared luminescence is crucial for the design of cost-effective and high-performance phosphor-converted infrared LEDs. However, the lack of ideal blue-pumped short-wave infrared (SWIR) phosphors with an emission peak longer than 900 nm greatly limits the development of SWIR LEDs using light converter technology. Here we have developed a series of SWIR-emitting materials with high luminescence efficiency and excellent thermal stability by co-doping Cr3+-Yb3+ ion pairs into Lu0.2Sc0.8BO3 host materials. Benefitting from strong light absorption of Cr3+ in the blue waveband and very efficient Cr3+→Yb3+ energy transfer, the as-synthesized Lu0.2Sc0.8BO3:Cr3+,Yb3+ phosphor emits intense SWIR light in the 900–1200 nm from Yb3+ under excitation with blue light at ~460 nm. The optimized phosphor presents an internal quantum yield of 73.6% and the SWIR luminescence intensity at 100 °C can still keep 88.4% of the starting value at 25 °C. SWIR LED prototype device based on Lu0.2Sc0.8BO3:Cr3+,Yb3+ phosphor exhibits exceptional luminescence performance, delivering SWIR radiant power of 18.4 mW with 9.3% of blue-to-SWIR power conversion efficiency and 5.0% of electricity-to-SWIR light energy conversion efficiency at 120 mA driving current. Moreover, under the illumination of high-power SWIR LED, covert information identification and night vision lighting have been realized, demonstrating a very bright prospect for practical applications.
Localised structuring of metal-semiconductor cores in silica clad fibres using laser-driven thermal gradients
Authors: Song Seunghan , Laurell Fredrik , Meehan Bailey , Hawkins Thomas W. , Ballato John , Gibson Ursula J.
Published: May 2022

The molten core drawing method allows scalable fabrication of novel core fibres with kilometre lengths. With metal and semiconducting components combined in a glass-clad fibre, CO2 laser irradiation was used to write localised structures in the core materials. Thermal gradients in axial and transverse directions allowed the controlled introduction, segregation and chemical reaction of metal components within an initially pure silicon core, and restructuring of heterogeneous material. Gold and tin longitudinal electrode fabrication, segregation of GaSb and Si into parallel layers, and Al doping of a GaSb core were demonstrated. Gold was introduced into Si fibres to purify the core or weld an exposed fibre core to a Si wafer. Ga and Sb introduced from opposite ends of a silicon fibre reacted to form III-V GaSb within the Group IV Si host, as confirmed by structural and chemical analysis and room temperature photoluminescence.
Cryo-EM structure of human glucose transporter GLUT4
Authors: Yuan Yafei , Kong Fang , Xu Hanwen , Zhu Angqi , Yan Nieng , Yan Chuangye
Published: May 2022

GLUT4 is the primary glucose transporter in adipose and skeletal muscle tissues. Its cellular trafficking is regulated by insulin signaling. Failed or reduced plasma membrane localization of GLUT4 is associated with diabetes. Here, we report the cryo-EM structures of human GLUT4 bound to a small molecule inhibitor cytochalasin B (CCB) at resolutions of 3.3 Å in both detergent micelles and lipid nanodiscs. CCB-bound GLUT4 exhibits an inward-open conformation. Despite the nearly identical conformation of the transmembrane domain to GLUT1, the cryo-EM structure reveals an extracellular glycosylation site and an intracellular helix that is invisible in the crystal structure of GLUT1. The structural study presented here lays the foundation for further mechanistic investigation of the modulation of GLUT4 trafficking. Our methods for cryo-EM analysis of GLUT4 will also facilitate structural determination of many other small size solute carriers.
CO2/carbonate-mediated electrochemical water oxidation to hydrogen peroxide
Authors: Fan Lei , Bai Xiaowan , Xia Chuan , Zhang Xiao , Zhao Xunhua , Xia Yang , Wu Zhen-Yu , Lu Yingying , Liu Yuanyue , Wang Haotian
Published: May 2022

Electrochemical water oxidation reaction (WOR) to hydrogen peroxide (H2O2) via a 2e− pathway provides a sustainable H2O2 synthetic route, but is challenged by the traditional 4e− counterpart of oxygen evolution. Here we report a CO2/carbonate mediation approach to steering the WOR pathway from 4e− to 2e−. Using fluorine-doped tin oxide electrode in carbonate solutions, we achieved high H2O2 selectivity of up to 87%, and delivered unprecedented H2O2 partial currents of up to 1.3 A cm−2, which represents orders of magnitude improvement compared to literature. Molecular dynamics simulations, coupled with electron paramagnetic resonance and isotope labeling experiments, suggested that carbonate mediates the WOR pathway to H2O2 through the formation of carbonate radical and percarbonate intermediates. The high selectivity, industrial-relevant activity, and good durability open up practical opportunities for delocalized H2O2 production.
Amazonian terrestrial water balance inferred from satellite-observed water vapor isotopes
Authors: Shi Mingjie , Worden John R. , Bailey Adriana , Noone David , Risi Camille , Fu Rong , Worden Sarah , Herman Robert , Payne Vivienne , Pagano Thomas , Bowman Kevin , Bloom A. Anthony , Saatchi Sassan , Liu Junjie , Fisher Joshua B.
Published: May 2022

Atmospheric humidity and soil moisture in the Amazon forest are tightly coupled to the region’s water balance, or the difference between two moisture fluxes, evapotranspiration minus precipitation (ET-P). However, large and poorly characterized uncertainties in both fluxes, and in their difference, make it challenging to evaluate spatiotemporal variations of water balance and its dependence on ET or P. Here, we show that satellite observations of the HDO/H2O ratio of water vapor are sensitive to spatiotemporal variations of ET-P over the Amazon. When calibrated by basin-scale and mass-balance estimates of ET-P derived from terrestrial water storage and river discharge measurements, the isotopic data demonstrate that rainfall controls wet Amazon water balance variability, but ET becomes important in regulating water balance and its variability in the dry Amazon. Changes in the drivers of ET, such as above ground biomass, could therefore have a larger impact on soil moisture and humidity in the dry (southern and eastern) Amazon relative to the wet Amazon.
Immunogenicity and safety of an intradermal ChAdOx1 nCoV-19 boost in a healthy population
Authors: Pinpathomrat Nawamin , Intapiboon Porntip , Seepathomnarong Purilap , Ongarj Jomkwan , Sophonmanee Ratchanon , Hengprakop Jariya , Surasombatpattana Smonrapat , Uppanisakorn Supattra , Mahasirimongkol Surakameth , Sawaengdee Waritta , Phumiamorn Supaporn , Sapsutthipas Sompong , Kongkamol Chanon , Ingviya Thammasin , Sangsupawanich Pasuree , Chusri Sarunyou
Published: May 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. Two doses of an inactivated SARS-CoV-2 vaccine (CoronaVac) have been shown to be insufficient to protect against variants of concern (VOCs), while viral vector vaccines remain protective against the infection. Herein, we conducted a preliminary study to evaluate the safety and immunity in an adult population who received the conventional 2 dosage-regimen of inactivated SARS-CoV-2 vaccine; with an additional intradermal ChAdOx1 nCoV-19 reciprocal dosage (1:5). An Intramuscular ChAdOx1 nCoV-19 booster was also included as a control. Immediate and delayed local reactions were frequently observed in the fractional intradermal boost, but systemic side effects were significantly decreased compared to the conventional intramuscular boost. The anti-RBD-IgG levels, the neutralising function against delta variants, and T cell responses were significantly increased after boosting via both routes. Interestingly, the shorter interval elicited higher immunogenicity compared to the extended interval. Taken together, a reciprocal dosage of intradermal ChAdOx1 nCoV-19 booster reduces systemic adverse reactions and enhances non inferiority humoral and cellular immune responses compared to a full dose of intramuscular boosting. These findings provide for an effective vaccine management during the shortages of vaccine supply.
Giant magnetochiral anisotropy from quantum-confined surface states of topological insulator nanowires
Authors: Legg Henry F. , Rößler Matthias , Münning Felix , Fan Dingxun , Breunig Oliver , Bliesener Andrea , Lippertz Gertjan , Uday Anjana , Taskin A. A. , Loss Daniel , Klinovaja Jelena , Ando Yoichi
Published: May 2022

Wireless technology relies on the conversion of alternating electromagnetic fields into direct currents, a process known as rectification. Although rectifiers are normally based on semiconductor diodes, quantum mechanical non-reciprocal transport effects that enable a highly controllable rectification were recently discovered1–9. One such effect is magnetochiral anisotropy (MCA)6–9, in which the resistance of a material or a device depends on both the direction of the current flow and an applied magnetic field. However, the size of rectification possible due to MCA is usually extremely small because MCA relies on inversion symmetry breaking that leads to the manifestation of spin–orbit coupling, which is a relativistic effect6–8. In typical materials, the rectification coefficient γ due to MCA is usually ∣γ∣ ≲ 1 A−1 T−1 (refs. 8–12) and the maximum values reported so far are ∣γ∣ ≈ 100 A−1 T−1 in carbon nanotubes13 and ZrTe5 (ref. 14). Here, to overcome this limitation, we artificially break the inversion symmetry via an applied gate voltage in thin topological insulator (TI) nanowire heterostructures and theoretically predict that such a symmetry breaking can lead to a giant MCA effect. Our prediction is confirmed via experiments on thin bulk-insulating (Bi1−xSbx)2Te3 (BST) TI nanowires, in which we observe an MCA consistent with theory and ∣γ∣ ≈ 100,000 A−1 T−1, a very large MCA rectification coefficient in a normal conductor.
Safety and antiviral activity of triple combination broadly neutralizing monoclonal antibody therapy against HIV-1: a phase 1 clinical trial
Authors: Julg Boris , Stephenson Kathryn E. , Wagh Kshitij , Tan Sabrina C. , Zash Rebecca , Walsh Stephen , Ansel Jessica , Kanjilal Diane , Nkolola Joseph , Walker-Sperling Victoria E. K. , Ophel Jasper , Yanosick Katherine , Borducchi Erica N. , Maxfield Lori , Abbink Peter , Peter Lauren , Yates Nicole L. , Wesley Martina S. , Hassell Tom , Gelderblom Huub C. , deCamp Allen , Mayer Bryan T. , Sato Alicia , Gerber Monica W. , Giorgi Elena E. , Gama Lucio , Koup Richard A. , Mascola John R. , Monczor Ana , Lupo Sofia , Rolle Charlotte-Paige , Arduino Roberto , DeJesus Edwin , Tomaras Georgia D. , Seaman Michael S. , Korber Bette , Barouch Dan H.
Published: May 2022

HIV-1 therapy with single or dual broadly neutralizing antibodies (bNAbs) has shown viral escape, indicating that at least a triple bNAb therapy may be needed for robust suppression of viremia. We performed a two-part study consisting of a single-center, randomized, double-blind, dose-escalation, placebo-controlled first-in-human trial of the HIV-1 V2-glycan-specific antibody PGDM1400 alone or in combination with the V3-glycan-specific antibody PGT121 in 24 adults without HIV in part 1, as well as a multi-center, open-label trial of the combination of PGDM1400, PGT121 and the CD4-binding-site antibody VRC07-523LS in five viremic adults living with HIV not on antiretroviral therapy (ART) in part 2 (NCT03205917). The primary endpoints were safety, tolerability and pharmacokinetics for both parts and antiviral activity among viremic adults living with HIV and not on ART for part 2 of the study. The secondary endpoints were changes in CD4+ T cell counts and development of HIV-1 sequence variations associated with PGDM1400, PGT121 and VRC07-523LS resistance in part 2. Intravenously administered PGDM1400 was safe and well-tolerated at doses up to 30 mg kg−1 and when given in combination with PGT121 and VRC07-523LS. A single intravenous infusion of 20 mg kg−1 of each of the three antibodies reduced plasma HIV RNA levels in viremic individuals by a maximum mean of 2.04 log10 copies per ml; however, viral rebound occurred in all participants within a median of 20 days after nadir. Rebound viruses demonstrated partial to complete resistance to PGDM1400 and PGT121 in vitro, whereas susceptibility to VRC07-523LS was preserved. Viral rebound occurred despite mean VRC07-523LS serum concentrations of 93 µg ml−1. The trial met the pre-specified endpoints. Our data suggest that future bNAb combinations likely need to achieve broad antiviral activity, while also maintaining high serum concentrations, to mediate viral control.
A studyforrest extension, MEG recordings while watching the audio-visual movie “Forrest Gump”
Authors: Liu Xingyu , Dai Yuxuan , Xie Hailun , Zhen Zonglei
Published: May 2022

Naturalistic stimuli, such as movies, are being increasingly used to map brain function because of their high ecological validity. The pioneering studyforrest and other naturalistic neuroimaging projects have provided free access to multiple movie-watching functional magnetic resonance imaging (fMRI) datasets to prompt the community for naturalistic experimental paradigms. However, sluggish blood-oxygenation-level-dependent fMRI signals are incapable of resolving neuronal activity with the temporal resolution at which it unfolds. Instead, magnetoencephalography (MEG) measures changes in the magnetic field produced by neuronal activity and is able to capture rich dynamics of the brain at the millisecond level while watching naturalistic movies. Herein, we present the first public prolonged MEG dataset collected from 11 participants while watching the 2 h long audio-visual movie “Forrest Gump”. Minimally preprocessed data was also provided to facilitate the use of the dataset. As a studyforrest extension, we envision that this dataset, together with fMRI data from the studyforrest project, will serve as a foundation for exploring the neural dynamics of various cognitive functions in real-world contexts.
Serum levels of anti-PF4 IgG after AZD1222 (ChAdOx1 nCoV-19) vaccination
Authors: Cohen Taylor S. , Kelly Elizabeth J. , Nylander Sven , Bansal Himanshu , Jepson Brett M. , Bhuyan Prakash , Sobieszczyk Magdalena E. , Falsey Ann R.
Published: May 2022

Rare cases of thrombosis with thrombocytopenia syndrome (TTS) have been reported after AZD1222. Anti-platelet factor-4 (PF4) antibodies were observed in patients following presentation of TTS, however it is unclear if AZD1222 was responsible for inducing production of anti-PF4. Paired samples (baseline and day-15) from a phase 3 trial of AZD1222 vs placebo were analyzed for anti-PF4 levels; 19/1727 (1.1%, AZD1222) vs 7/857 (0.8%, placebo) participants were anti-PF4-IgG-negative at baseline but had moderate Day-15 levels (P = 0.676) and 0/35 and 1/20 (5.0%) had moderate levels at baseline but high Day-15 levels. These data indicate that AZD1222 does not induce a clinically relevant general increase in anti-PF4 IgG.
Closed-wound negative pressure therapy dressing after loop ostomy closure: a retrospective comparative study
Authors: Curchod P. , Clerc D. , Jurt J. , Hubner M. , Hahnloser D. , Demartines N. , Grass F.
Published: May 2022

Closed-wound negative pressure wound therapy (NPWT) dressings were recently introduced with the purpose to reduce incisional surgical site infections (iSSI) in high-risk wounds. The aim of this study was to compare iSSI rates in patients after ostomy closure with and without additional application of a closed-wound NPWT dressing. Single-center retrospective analysis of consecutive patients undergoing ileo- or colostomy closure over an 8-year period (January 2013—January 2021). Intradermal non-purse string technique with absorbable sutures were used in all patients. Since November 2018, all patients (study group) received a NPWT device for a maximum of 5 days postoperatively (PICO, SMITH AND NEPHEW). Primary outcome was iSSI rate within 30 days of surgery. SSI was defined in accordance with the Center of Disease Control (CDC) classification and included superficial and deep incisional SSI. Data was retrieved from the institutional enhanced recovery after surgery (ERAS) database, with standardized complication assessment by trained abstractors. In total, 85 patients (25%) in the study group were comparable with 252 (75%) patients in the control group regarding demographics (age, gender, body mass index, ASA score), ostomy type and anastomotic technique (all p > 0.05), but not wound contamination class (class III: 5% vs 0%, p < 0.001). Median time to NPWT removal was 4 (IQR 3–5) days. Incisional SSI were observed in 4 patients (4.7%) in the study group and in 27 patients (10.7%) in the control group (p = 0.097). These preliminary results suggest a potential benefit of systematic application of the NPWT device after loop ostomy closure. A randomized controlled study is needed.
A Novel CNN-based Bi-LSTM parallel model with attention mechanism for human activity recognition with noisy data
Authors: Yin Xiaochun , Liu Zengguang , Liu Deyong , Ren Xiaojun
Published: May 2022

Boosted by mobile communication technologies, Human Activity Recognition (HAR) based on smartphones has attracted more and more attentions of researchers. One of the main challenges is the classification time and accuracy in processing long-time dependent sequence samples with noisy or missed data. In this paper, a 1-D Convolution Neural Network (CNN)-based bi-directional Long Short-Term Memory (LSTM) parallel model with attention mechanism (ConvBLSTM-PMwA) is proposed. The original features of sensors are segmented into sub-segments by well-designed equal time step sliding window, and fed into 1-D CNN-based bi-directional LSTM parallel layer to accelerate feature extraction with noisy and missed data. The weights of extracted features are redistributed by attention mechanism and integrated into complete features. At last, the final classification results are obtained with the full connection layer. The performance is evaluated on public UCI and WISDM HAR datasets. The results show that the ConvBLSTM-PMwA model performs better than the existing CNN and RNN models in both classification accuracy (96.71%) and computational time complexity (1.1 times faster at least), even if facing HAR data with noise.
Three-dimensional gait analysis of lower extremity gait parameters in Japanese children aged 6 to 12 years
Authors: Ito Tadashi , Noritake Koji , Ito Yuji , Tomita Hidehito , Mizusawa Jun , Sugiura Hiroshi , Matsunaga Naomichi , Ochi Nobuhiko , Sugiura Hideshi
Published: May 2022

We aimed to develop gait standards for gait parameters in school-aged Japanese children and assess age-related differences in gait patterns and parameters. Children aged 6–12 years (n = 424) were recruited from two elementary schools. An instrumented three-dimensional gait analysis system was used to record each child's gait kinematics, kinetics, and spatiotemporal parameters. Participants were subdivided into three age groups (Group A, 6–8 years; Group B, 9–10 years; and Group C, 11–12 years). LMS Chartmaker, version 2.54, was used to create a developmental chart for the gait pattern. The non-normalized step and stride lengths were significantly longer, and the cadence was lower in older children; however, the opposite outcome occurred when analyzing normalized data. Ankle moment differed significantly by age, and the maximum ankle moment was higher in older children than that in younger children. Furthermore, the hip and knee flexion angles during gait and the normalized spatiotemporal parameters of Japanese children aged 6–12 years differed by age and from those of children from other countries. The centile chart of the gait pattern is a useful tool for clinicians to assess developmental changes in the gait pattern and detect gait abnormalities in children.