bluuebunny/crossref_metadata_2025 huggingface dataset:
Horse-Derived Ceramide Accentuates Glucosylceramide Synthase and Ceramide Synthase 3 by Activating PPARβ/δ and/or PPARγ to Stimulate Ceramide Synthesis
Authors: Igarashi Tami , Yanagi Hiroki , Yagi Masayuki , Ichihashi Masamitsu , Imokawa Genji
Published: February 2023

Horse-derived ceramide (HC), which contains galactosylceramides as its main component, significantly improves skin symptoms when applied topically to patients with atopic dermatitis. We speculated that efficacy resulted from the amelioration of epidermal ceramide metabolism, and we characterized those effects using reconstructed human epidermal equivalents. Lipid analysis, RT-PCR and Western blotting revealed that HC significantly increased the total ceramide content of the stratum corneum (SC), accompanied by significantly increased gene and/or protein expression levels of ceramide synthase (CERS) 3, fatty acid elongase (ELOVL) 4, glucosylceramide synthase (GCS), β-glucocerebrosidase, sphingomyelin synthase and acid sphingomyelinase. Mechanistic analyses using cultures of primary human keratinocytes revealed the marked stimulatory effects of HC on the mRNA expression levels of CERS3, ELOVL4 and GCS under high calcium-derived differentiation conditions. Signaling analyses demonstrated that an antagonist of PPARβ/δ significantly abrogated the HC-stimulated mRNA expression levels of GCS, CERS3 and ELOVL4. GW9662, an antagonist of PPARγ, significantly abolished the HC-up-regulated mRNA expression levels of GCS and ELOVL4, but not of CERS3. These findings suggest that HC has the distinct potential to accentuate the expression of GCS, CERS3 and ELOVL4 via the activation of PPARβ/δ and/or PPARγ to accelerate ceramide synthesis in the SC.
Role of the Intestinal Microbiota in the Genesis of Major Depression and the Response to Antidepressant Drug Therapy: A Narrative Review
Authors: Mundula Tiziana , Baldi Simone , Gerace Elisabetta , Amedei Amedeo
Published: February 2023

A major depressive disorder is a serious mental illness characterized by a pervasive low mood that negatively concerns personal life, work life, or education, affecting millions of people worldwide. To date, due to the complexity of the disease, the most common and effective treatments consist of a multi-therapy approach, including psychological, social, and pharmacological support with antidepressant drugs. In general, antidepressants are effective in correcting chemical imbalances of neurotransmitters in the brain, but recent evidence has underlined the pivotal role of gut microbiota (GM) also in the regulation of their pharmacokinetics/pharmacodynamics, through indirect or direct mechanisms. The study of these complex interactions between GM and drugs is currently under the spotlight, and it has been recently named “pharmacomicrobiomics”. Hence, the purpose of this review is to summarize the contribution of GM and its metabolites in depression, as well as their role in the metabolism and activity of antidepressant drugs, in order to pave the way for the personalized administration of antidepressant therapies.
The Effectiveness of Suffruticosol B in Treating Lung Cancer by the Laser Trapping Technique
Authors: Goangul Mulugeta S. , Solomon Rance M. , Devito Daniel L. , Brown Charles A. , Coopper James , Erenso Daniel B. , Gao Ying , Pellizzaro Aline , Revalee Jennifer M. , Crogman Horace T.
Published: February 2023

We used laser trapping to study the effects of suffruticosol B on lung cancer cells. Physical and mechanical changes were found to be statistically significant, with a 63.97% increase over untreated cells and a 79.57% increase over untreated cells after treatment for 3 or 6 h, respectively. The treatment affected the internal structure of the cells, with changes in their elastic properties. The cellular responses showed that treatment with suffruticosol B resulted in the decreased proliferation and invasion of cancer cells. These results suggest that the treatment may be useful in preventing or treating lung cancer.
Multicriteria Assessment for Calculating the Optimal Content of Calcium-Rich Fly Ash in Metakaolin-Based Geopolymers
Authors: Sharko Artem , Louda Petr , Nguyen Van Vu , Buczkowska Katarzyna Ewa , Stepanchikov Dmitry , Ercoli Roberto , Kascak Patrik , Le Van Su
Published: February 2023

This study examines the impact of calcium-rich fly ash as an additive on metakaolin-based geopolymers. Six types of fly ash (FA1-FA7) from different thermal power plants in the Czech Republic were collected and characterized based on their physical and chemical properties. The addition of fly ash into the geopolymers was evaluated through a multicriteria assessment that focused on density and mechanical properties. By using a multi-criteria approach, the assessment provides a comprehensive and holistic evaluation of the material, allowing for a more informed decision about the optimal addition of additives. This approach helps to minimize any negative impact on the material’s properties while maximizing the utilization of the by-product. The result is an optimized geopolymer mixture with improved properties and increased sustainability, as the by-product is used beneficially. Furthermore, calcium content is the key factor that affects the physical properties of geopolymers by accelerating the curing time. This rapid process can result in reduced strength with increasing fly ash content. The multicriteria assessment revealed that the optimal condition is achieved using fly ash (FA2) from the Loucovice thermal power plant (5.2 wt.% Ca) that was treated at a temperature of 615 °C. The flexural strength of FA2-based geopolymers increased by 13% compared to concrete (standard). However, the addition of fly ash significantly reduced the compressive strength of geopolymers throughout the range of specimens. The Charpy impact strength of FA2 was higher than the standard due to the presence of unburned biomass solids in the ash structure that can absorb energy easily.
Neuroprotective Effects of Geopung-Chunghyuldan Based on Its Salvianolic Acid B Content Using an In Vivo Stroke Model
Authors: Lee Han-Gyul , Kwon Seungwon , Moon Sang-Kwan , Cho Seung-Yeon , Park Seong-Uk , Jung Woo-Sang , Park Jung-Mi , Ko Chang-Nam , Cho Ki-Ho
Published: February 2023

Background: Geopung-Chunghyuldan (GCD) has neuroprotective properties. Salviae miltiorrhizae Radix plays an essential role in GCD’s effect. The Salviae miltiorrhizae Radix marker compound is salvianolic acid B; however, its content is not uniform among samples. This study aimed to evaluate the neuroprotective effects of GCD based on salvianolic acid B content. Methods: The neuroprotective effects of GCD based on the salvianolic acid B content were evaluated by measuring infarct volume 24 h after permanent middle cerebral artery occlusion in an in vivo stroke model. For the experimental group, each GCD was administered immediately before surgery. The control groups were administered distilled water and aspirin (30 mg/kg) in the same way. The salvianolic acid B content in five types of Salviae Miltiorrhizae Radix (two Chinese and three Korean regions) based on different cultivation regions was analyzed by high-performance liquid chromatography. Results: Three samples met the Korean and Chinese Pharmacopeia standards for salvianolic acid B. However, two samples did not. GCDs with high salvianolic acid B showed marked neuroprotective effects compared to the control groups, whereas GCDs with low salvianolic acid B did not. Conclusions: The salvianolic acid B content of Salviae miltiorrhizae Radix affects the neuroprotection effect of GCD. Stable, raw Salviae miltiorrhizae Radix is essential for GCD homogenization.
Invasion Potential of Ornamental Terrestrial Gastropods in Europe Based on Climate Matching
Authors: Bohatá Lucie , Patoka Jiří
Published: February 2023

Invasive species are one of the main causes of biodiversity loss worldwide. Pet trade is a well-known pathway for the introduction of non-native species. Prevention is the most effective, least time-consuming, and least financially demanding way to protect biodiversity against the spreading of invasive species. The main part of prevention is the early detection of a potentially high-risk species, as well as the successful implementation of prevention strategies in legislation and practice. This study summarizes the pre-introduction screening of pet-traded terrestrial gastropod species and their potential occurrence in the EU territory. Based on the list of species traded in the Czech Republic, one of the most important global hubs of the pet trade, 51 species (49 snails and 2 slugs) were analysed. Due to a lack of certain native occurrence data, only 29 species (28 snails and 1 slug) from 10 families were modelled using MaxEnt software. Twenty species from seven families have potential occurrence in the EU territory. Based on MaxEnt modelling, we considered the following species to be high-risk candidates for the EU: Anguispira alternata, A. strongylodes, Laevicaulis alte, Megalobulismus oblongus, Rumina decollata, and R. saharica. Based on this estimation, we present considerations with which to further improve the risk assessment and recommend continuous monitoring of the pet trade market.
Histopathological Diagnosis of Malignant Melanoma at the Dawn of 2023: Knowledge Gained and New Challenges
Authors: Cazzato Gerardo
Published: February 2023

Year after year, the incidence and prevalence rates of cutaneous Malignant Melanoma (MM) show a continuous increase and, according to the most up-to-date American Cancer Society (ACS) projections, it is estimated that 97,610 new melanomas will be diagnosed in 2023 (about 58,120 in men and 39,490 in women) and approximately 7990 people are expected to die of melanoma (about 5420 men and 2570 women) [...]
The Nexus between Crime Rates, Poverty, and Income Inequality: A Case Study of Indonesia
Authors: Sugiharti Lilik , Purwono Rudi , Esquivias Miguel Angel , Rohmawati Hilda
Published: February 2023

This study examines whether income inequality and poverty are determinants of crime rates across 34 provinces in Indonesia. Three indicators of income inequality and four poverty measures are tested to examine whether the dimension and degree of unequal welfare distribution are linked to crime occurrences. We use panel data from 2010 to 2019 with the Generalized Method of Moments (GMM) approach. The findings indicate that higher income levels and wider income inequality are associated with higher crime rates. Our first indicator of income inequality, non-food expenditure, has a larger impact on crime rates than our second and third indicators, i.e., the gap in food expenditure and the Gini ratio. Poverty is also positively associated with crime. The wider the poverty gap (a measure of poverty) and the severity index, the higher the deprivation levels among the poor, which lead to more crime. The significant and positive effect of poverty on crime rates, and the positive nexus between crime, income, and inequality suggest that Indonesia will face a higher crime risk as the country becomes increasingly more affluent. In such a scenario, policymakers can leverage education and investment (domestic and foreign) to minimize the crime rate. The government could also strengthen crime prevention programs, crime settlement systems, and policing in Indonesia, and raise the budget for social assistance.
Design and Assessment of Survey in a 360-Degree Feedback Environment for Student Satisfaction Analysis Applied to Industrial Engineering Degrees in Spain
Authors: Granados-Ortiz Francisco-Javier , Gómez-Merino Ana Isabel , Jiménez-Galea Jesús Javier , Santos-Ráez Isidro María , Fernandez-Lozano Juan Jesús , Gómez-de-Gabriel Jesús Manuel , Ortega-Casanova Joaquín
Published: February 2023

The number of students enrolled in engineering studies in Spain is in decline, mainly due to the difficulty in passing the subjects, whose factors may be linked to the science-related content of the subject, a very demanding evaluation system or a lack of active participation of students. The main objective of this study is to provide the student with a 360-degree feedback tool and a survey, from which lecturers can extract the degree of satisfaction of students in its application in a standardized way in scientific-technological activities of BSc/MSc in industrial engineering to quantify learning and motivation. The involvement of students in the assessment process was carried out in three phases: peer-assessment (among students), self-assessment (student himself) and hetero-assessment (teaching staff). After that, a survey was designed, which was validated through confirmatory factor analysis. Ninety-nine percent of the students valued this evaluation experience very positively with respect to the objectivity of the criteria used in the methodology and the material provided by the teaching staff. The fact that only 37.5% of the students considered this experience very favorable for their learning and self-training shows the importance of the teaching staff in their learning process and suggests a need to find complementary improvements to this evaluation system in industrial engineering degrees.
Online Mode of Teaching and Learning Process in Engineering Discipline: Teacher Perspective on Challenges Faced and Recommendations
Authors: Akhtar Saleem , Nadeem Muhammad , Rashdan Mostafa , Hussain Bashir , Ansari Ejaz Ahmad , Aslam Mian Hassan
Published: February 2023

The COVID-19 pandemic has affected people from almost every walk of life in general and academia in particular. It had a huge impact on teaching and learning resulting in a sudden shift from classroom and face-to-face teaching to distance and online teaching and learning. This sudden shift created a lot of ruckuses in the teaching of engineering disciplines. This study is pertinent to the examination of faculty perceptions of online teaching in Pakistani universities and the obstacles they face in teaching engineering students through the online mode during this pandemic. The research takes a quantitative and sample survey approach. A Google form questionnaire was used to collect the data from a sample of 91 faculty members from the engineering discipline of different universities in Pakistan during 2022. According to the study’s findings, faculty generally have a favorable opinion of virtual teaching in the context of COVID-19 for closing the achievement gap and guiding students’ futures in difficult times. However, they ran into a number of challenges when teaching online, including technological difficulties, problems with student participation, challenges with online tests and assessments, etc. The results of this study will urge educational institutions and policymakers to use the most up-to-date instructional methodologies and offer teachers ongoing professional development in order to improve the quality of online teaching, learning, and assessment in universities. Previous studies discussed a number of obstacles faced by students in virtual teaching in higher education, overlooking the perception and challenges faced by the engineering faculty. The present study replenishes this gap.
Factors That Influence Mobile Learning among University Students in Romania
Authors: Voicu Mirela-Catrinel , Muntean Mihaela
Published: February 2023

During the pandemic years, universities worldwide adopted online teaching on a large scale. Besides desktop systems or laptops, many students also use smartphones for online learning. In our paper, we propose a hybrid theoretical model to analyze the continuance intention to use mobile learning in higher education. The scientific demarche is carried out from different perspectives opened by the models and theories integrated in a unitary approach. In addition to the main constructs taken from the Technology Acceptance Model (TAM) and the Unified Theory of Acceptance and Use of Technology (UTAUT), the research model was enriched with new capabilities by considering the Motivational Model (MM), Flow Theory (FT) and the Social Cognitive Theory (SCT). The research model was applied to the Romanian higher education environment and proved that perceived usefulness (PU), habit (HB), perceived skill (PS), and self-efficacy (SE) directly influence the continuance intention to use (CU) smartphones in higher education. Further, performance expectancy (PFE), intrinsic motivation (IM), perceived ease of use (PEOU), and perceived enjoyment (PE) indirectly influence the continuance intention to use (CU). We presented our results according to top studies on the critical challenges and factors influencing smart mobile learning success usage during the COVID-19 pandemic. Thus, we found that Romanian universities provide excellent IT infrastructure and top management support and that creating habits of using m-learning in the context of university classes will strengthen the university culture. The conclusions of the undertaken research represent a starting point in the diversification and flexibility of educational processes in Romanian universities.
Characterization of the Dynamic RON of 600 V GaN Switches under Operating Conditions
Authors: Alemanno Alessio , Santarelli Alberto , Sangiorgi Enrico , Florian Corrado
Published: February 2023

High-voltage GaN switches can offer tremendous advantages over silicon counterparts for the development of high-efficiency switching-mode power converters at high commutation frequency. Nonetheless, GaN devices are prone to charge-trapping effects that can be particularly relevant in the early-stage development of new technologies. Charge-trapping mechanisms are responsible for the degradation of the dynamic ON-resistance (RON) with respect to its static value: this degradation is typically dependent on the blocking voltage, the commutation frequency and temperature, and is responsible for the reduction of power converter efficiency. The characterization of this phenomenon is very valuable for the development of a new process to compare different technological solutions or for the final assessment of performance. This characterization cannot be made with traditional static or small signal measurements since RON degradation is triggered by application-like dynamic device excitations. In this paper, we propose a technique for the characterization of the dynamic RON of high-voltage GaN switches under real operating conditions: this technique is based on the design of a half bridge switching leg in which the DUT is operated under conditions that resemble its operation in a power converter. With this setup, the characterization of a 600 V GaN switch dynamic RON is performed as a function of variable blocking voltages and commutation frequency. Additionally, this technique allows the separation of thermal and trapping effects, enabling the characterization of the dynamic RON at different temperatures.
A Review on Process Modeling and Simulation of Cryogenic Carbon Capture for Post-Combustion Treatment
Authors: Asgharian Hossein , Iov Florin , Araya Samuel Simon , Pedersen Thomas Helmer , Nielsen Mads Pagh , Baniasadi Ehsan , Liso Vincenzo
Published: February 2023

The cryogenic carbon capture (CCC) process is a promising post-combustion CO2 removal method. This method is very novel compared with conventional and well-developed methods. However, cryogenic carbon capture is not yet commercially available despite its techno-economic benefits. Thus, a model-based design approach for this process can provide valuable information. This paper will first introduce the cryogenic carbon capture process. Then, a comprehensive literature overview that focuses on different methods for modeling the process at the component level will be given. The modelling methods which are deemed most effective are presented more in depth for each of the key system components. These methods are compared with each other in terms of complexity and accuracy and the simplest methods with an acceptable level of precision for modelling a specific component in the CCC process are recommended. Furthermore, potential research areas in modeling and simulation of the CCC process are also highlighted.
Research on Aerodynamic Design of an End Wall Based on a Quasi-3D Optimization Method
Authors: Yan Tingsong , Chen Huanlong , Wu Zhiqian , Liu Yang , Yan Peigang
Published: February 2023

To investigate the effects of different passage structures on the aerodynamic performance of the transonic fans, this paper develops a reliable and practical quasi-3D optimization method for the hub based on the experimental data of Stage 67. In the method, the hub profile of Stage 67 can be optimized without changing the geometrical data of the blades. The optimization results show that stream tube diffusion characteristics depend on the hub profile’s curvature in the boundary layer near the hub. In the front part of the hub, the end wall with a concave construction can enhance the expansion of the stream tubes near the root of the rotor blade, which helps control the diffusion flow of viscous fluid effectively to decrease the low-energy fluid’s energy degradation and radial secondary flow in the boundary layer. In the latter part of the hub, the end wall with a convex construction facilitates the shrinkage of stream tubes to decrease the secondary flow loss and separated flow loss by controlling the separation of the boundary layer efficiently. This construction of the hub profile is beneficial to promote the aerodynamic performance of a transonic fan.
Life Cycle Assessment of Luminescent Solar Concentrators Integrated into a Smart Window
Authors: Muteri Vincenzo , Longo Sonia , Traverso Marzia , Palumbo Elisabetta , Bua Letizia , Cellura Maurizio , Testa Daniele , Guarino Francesco
Published: February 2023

The main goal of this paper is to assess the life cycle environmental impacts of a multifunctional smart window luminescent solar concentrator (SW–LSC) prototype through the application of the Life Cycle Assessment methodology. To the authors’ knowledge, this is one of the first studies on the topic. The analysis followed a cradle to gate approach, considering the assembly and maintenance phase as well as the end of life, examined separately through a recycling/landfill scenario. A comparison of the impacts of LSC modules with those of some building-integrated photovoltaic technologies was carried out. Results showed that the global warming potential (100 years) for SW–LSC was 5.91 × 103 kg CO2eq and the manufacturing phase had the greatest impact (about 96%). The recycling/landfill scenario results showed the possibility to reduce impacts by an average of 45%. A dominance analysis of SW–LSC components showed that the aluminum frame was the main hotspot (about 60% contribution), followed by the light-shelf (about 19%). Batteries and motors for the shading system were the biggest contributors in the abiotic depletion potential category (36% and 30%, respectively). An alternative scenario, which involved the use of 75% recycled aluminum for the window frame, highlighted the possibility to reduce environmental impacts from 3% to 46%. Finally, the comparison results showed that the LSC modules’ impacts were on average 870% lower than that of various PV technologies when compared on the basis of m2; on the contrary, LSC modules had the highest impacts in all categories (from 200% to 1900%) when compared with other PV technologies on the basis of 1 kWh of energy generated. The results could be used for the definition of eco-design strategies for the examined device, in order to support the scaling-up process and to put “greener” systems onto the market.
Traveling Wave-Based Fault Localization in FACTS-Compensated Transmission Line via Signal Decomposition Techniques
Authors: Mishra Saswati , Gupta Shubhrata , Yadav Anamika , Abdelaziz Almoataz Y.
Published: February 2023

Modern power systems are structurally complex and are vulnerable to undesirable events like faults. In the event of faults in transmission line, accurate fault location improves restoration process, thereby enhancing the reliability of the overall system. Fault location methods (FLMs) are tools which assist in identifying fault locations quickly. However, the accuracy of these FLMs gets affected in the presence of flexible alternating current transmission system (FACTS) devices. Therefore, in this work, the performance of four different signal decomposition techniques aided traveling wave aided FLMs are qualitatively compared in the context of fault localization in FACTS-compensated systems. FLMs based on intrinsic time decomposition (ITD), empirical mode decomposition (EMD), S-transform (ST), and estimation of signal parameters via rotational invariance technique (ESPRIT) are investigated. The accuracy of FLMs is tested for different cases of series, shunt, and series-shunt FACTS-compensated systems. A 500 kV system employed with 100 MVAr FACTS device is used for simulation. The instant of arrival wave at end of transmission line is from all aforementioned FLMs. The obtained ATWs are used in fault localization. Further, the associated percentage errors are calculated. The results suggest that EMD and ESPRIT-based FLMs are more accurate than others.
Opportunities for Promoting Healthy Homes and Long-Lasting Energy-Efficient Behaviour among Families with Children in Portugal
Authors: Gabriel Marta Fonseca , Cardoso João Pedro , Felgueiras Fátima , Azeredo Joana , Filipe David , Conradie Peter , Van Hove Stephanie , Mourão Zenaida , Anagnostopoulos Filippos , Azevedo Isabel
Published: February 2023

Energy poverty vulnerability constitutes a significant concern in Portugal, with 17.5% of the population being unable to keep their home adequately warm. Furthermore, there is evidence that a substantial number of children live in unhealthy homes. This study aims to comprehensively characterise a sample of 101 Portuguese families with children and their homes in order to identify opportunities for actions for promoting long-lasting energy efficiency and environment health-promoting behavioural changes. To accomplish this aim, two tools—a building survey checklist and a questionnaire to participants—were developed and implemented to collect harmonised data on building-specific characteristics and on participants’ socioeconomic status and behaviour. The home visits for recruitment and data collection were conducted from July 2021 to April 2022. The results suggest that, for the population under study, the main opportunities for improvement include: (i) replacing low energy-efficient technologies, with high emission rates, namely those used for heating purposes, with cleaner and more efficient alternatives; (ii) providing citizens with detailed information about their home’s energy use and indoor air quality and (iii) educating the population on the best-practices for reducing indoor air stuffiness, mitigating the risk of hazardous exposures, improving thermal comfort and saving energy.
Comparative Levelized Cost Analysis of Transmitting Renewable Solar Energy
Authors: Thai Clinton , Brouwer Jack
Published: February 2023

A bottom-up cost analysis for delivering utility-scale PV-generated electricity as hydrogen through pipelines and as electricity through power is undertaken. Techno-economic, generation, and demand data for California are used to calculate the levelized cost of transmitting (LCOT) energy and the levelized cost of electricity (LCOE) prior to distribution. High-voltage levels of 230 kV and 500 kV and 24-inch and 36-inch pipelines for 100 to 700 miles of transmission are considered. At 100 miles of transmission, the cost of transmission between each medium is comparable. At longer distances, the pipeline scenarios become increasingly cheaper at low utilization levels. The all-electric pathways utilizing battery energy storage systems can meet 95% of the load for as low as 356 USD/MWh, whereas when meeting 100% of load with the hydrogen gas turbine and fuel cell pathways, the costs are 278 and 322 USD/MWh, respectively.
Comparative Analysis of Heating Efficiency of a Single-Well Geothermal System in the Cold Region of Northeast China
Authors: Feng Bo , Ren Hao , Yang Yabin , Cui Zhenpeng , Zhao Jichu
Published: February 2023

Geothermal energy is a type of renewable energy that has rich reserves, is clean, environmentally friendly and has been widely used in the heating industry. The single-well closed-loop geothermal system is a technology with the characteristics of “taking heat without taking water” and is mainly used for geothermal energy heating. Although the heating requirements in the cold region of Northeast China are urgent, the traditional heating mode not only has high economic costs but also causes serious damage to the environment. Therefore, it is of important practical significance to change the heating structure and develop and utilize geothermal energy for heating according to local conditions. In this study, the actual operating single-well geothermal system in the Songyuan area of Jilin Province is used as a case study, and a numerical model is established based on the T2WELL simulation program. The flow production temperature and heat extraction response law of the single-well system in the M1 and M2 wells are contrasted and analyzed under the three key factors of geothermal gradient and injection temperature and flow rate. Based on the simulation results, an optimized development and utilization plan for the M1 and M2 wells is proposed. These results provide a theoretical reference and heating potential evaluation for the promotion of single-well geothermal systems in Northeast China. Taking the geothermal gradient of 4.2 ° C/hm as an example, after 30 years of operation, the heat extraction of the M1 well is 406 kW, and that of the M2 well is 589 kW. Compared with the M1 well, although the M2 well has higher heat extraction, the radial variation in reservoir temperature is more than 50 m under long-term operation, which is not conducive to long-term development and utilization.
A Hierarchical Cooperative Frequency Regulation Control Strategy of Wind-Storage-Load in a Microgrid Based on Model Prediction
Authors: Wang Yicong , Liu Chang , Liu Zhiwei , Wang Tingtao , Ke Fangchao , Yang Dongjun , Zhang Dongyin , Miao Shihong
Published: February 2023

In order to give full play to the frequency regulation ability of multiple types of resources such as wind power, energy storage, and controllable load in a microgrid, this paper proposes a hierarchical cooperative frequency regulation control strategy of wind-storage-load in a microgrid based on model prediction. Firstly, according to the operation characteristics of each resource in the microgrid, a hierarchical cooperative frequency regulation architecture of wind-storage-load is constructed. On this basis, the frequency regulation control models of wind power, energy storage, and controllable load are established, respectively, and the calculation method of the characteristic index of the system frequency response is proposed. Then, taking the maximum frequency deviation as the stratification index, a hierarchical cooperative frequency regulation control strategy of wind-storage-load based on model prediction is proposed, and a power compensation strategy for connecting the wind turbine frequency support is proposed for the wind turbine speed recovery stage. Finally, a microgrid model including wind power, energy storage, and controllable load is built on Matlab/Simulink for simulation analysis. The simulation results show that the proposed control strategy can control wind power, energy storage, and controllable load to participate in frequency modulation in advance, and improve the frequency stability of the system.
High-Gravity Fermentation for Bioethanol Production from Industrial Spent Black Cherry Brine Supplemented with Whey
Authors: Gómez Cardozo Javier Ricardo , Beigbeder Jean-Baptiste , Dantas Julia Maria de Madeiros , Lavoie Jean-Michel
Published: February 2023

By-products from different industries could represent an available source of carbon and nitrogen which could be used for bioethanol production using conventional Saccharomyces cerevisiae yeast. Spent cherry brine and whey are acid food by-products which have a high organic matter content and toxic compounds, and their discharges represent significant environmental and economic challenges. In this study, different combinations of urea, yeast concentrations, and whey as a nutrient source were tested for bioethanol production scale-up using 96-well microplates as well as 7.5 L to 100 L bioreactors. For bioethanol production in vials, the addition of urea allowed increasing the bioethanol yield by about 10%. Bioethanol production in the 7.5 L and 100 L bioreactors was 73.2 g·L−1 and 103.5 g·L−1 with a sugar consumption of 81.5% and 94.8%, respectively, using spent cherry brine diluted into whey (200 g·L−1 of total sugars) supplemented with 0.5 g·L−1 urea and 0.5 g·L−1 yeast at 30 °C and a pH of 5.0 after 96 h of fermentation for both systems. The results allow these by-products to be considered low-economic-value alternatives for fuel- or food-grade bioethanol production.
Collaborative Storage and Resolution Method between Layers in Hierarchical ICN Name Resolution Systems
Authors: Li Yanxia , Li Yang
Published: February 2023

Name resolution system is an important infrastructure in Information Centric Networking (ICN) network architecture of identifier–locator separation mode. In the Local Name Resolution System (LNMRS), a hierarchical name resolution system for latency-sensitive scenarios; higher-level resolution nodes serve more users and suffer more storage pressure, which causes the problem of unbalanced storage load between layers, and requires inter-layer collaborative storage under the constraint of deterministic service latency characteristics. In this paper, we use the constraints required for inter-layer collaborative resolution to construct an index neighbor structure and perform collaborative storage based on this structure. This method relieves storage pressure on high-level resolution nodes. Experimental results show that the increase of total storage load brought by the proposed method is 57.1% of that by MGreedy algorithm, 8.1% of that by Greedy algorithm, and 0.8% of that by the K-Mediod algorithm when relieving the same storage load for high-level resolution nodes. Meanwhile, deterministic service latency feature is still sustained when our proposed method is used for collaborative resolution.
Levels and Health Risk Assessment of Polycyclic Aromatic Hydrocarbons in Vegetable Oils and Frying Oils by Using the Margin of Exposure (MOE) and the Incremental Lifetime Cancer Risk (ILCR) Approach in China
Authors: Liu Qing , Wu Pinggu , Zhou Pingping , Luo Pengjie
Published: February 2023

A total of 139 vegetable oils and 48 frying oils produced in China were tested for the levels of 15 Environmental Protection Agency-regulated polycyclic aromatic hydrocarbons (PAHs). The analysis was completed by high-performance liquid chromatography-fluorescence detection (HPLC-FLD). The limit of detection and limit of quantitation were ranged between 0.2–0.3 and 0.6–1 μg/kg, respectively. The average recovery was 58.6–90.6%. The highest mean of total PAHs was found in peanut oil (3.31 μg/kg), while the lowest content was found in olive oil (0.39 μg/kg). In brief, 32.4% of vegetable oils exceeded the European Union maximum levels in China. The detected level of total PAHs in vegetable oils was lower than the frying oils. The mean dietary exposure to PAH15 ranged from 0.197 to 2.051 ng BaPeq/kg bw/day. The margin of exposure values was greater than 10,000, and the cumulative probabilities of the incremental lifetime cancer risk of different age groups were less than the priority risk level (10−4). Therefore, there was no potential health concern for specific populations.
TCF7L1 Regulates LGR5 Expression in Colorectal Cancer Cells
Authors: King Carli M. , Marx Olivia M. , Ding Wei , Koltun Walter A. , Yochum Gregory S.
Published: February 2023

Mutations in components of the Wnt/β-catenin signaling pathway drive colorectal cancer (CRC), in part, by deregulating expression of genes controlled by the T-cell factor (TCF) family of transcription factors. TCFs contain a conserved DNA binding domain that mediates association with TCF binding elements (TBEs) within Wnt-responsive DNA elements (WREs). Intestinal stem cell marker, leucine-rich-repeat containing G-protein-coupled receptor 5 (LGR5), is a Wnt target gene that has been implicated in CRC stem cell plasticity. However, the WREs at the LGR5 gene locus and how TCF factors directly regulate LGR5 gene expression in CRC have not been fully defined. Here, we report that TCF family member, TCF7L1, plays a significant role in regulating LGR5 expression in CRC cells. We demonstrate that TCF7L1 binds to a novel promoter-proximal WRE through association with a consensus TBE at the LGR5 locus to repress LGR5 expression. Using CRISPR activation and interference (CRISPRa/i) technologies to direct epigenetic modulation, we demonstrate that this WRE is a critical regulator of LGR5 expression and spheroid formation capacity of CRC cells. Furthermore, we found that restoring LGR5 expression rescues the TCF7L1-mediated reduction in spheroid formation efficiency. These results demonstrate a role for TCF7L1 in repressing LGR5 gene expression to govern the spheroid formation potential of CRC cells.
Obesity-Related Factors in Adult Women with Early Menarche
Authors: Cho Hunha , Han Jeong-Won
Published: February 2023

The average menarche age among South Korean women has decreased over time. Early menarche in women causes a higher incidence of obesity owing to the continuous fat accumulation induced by prolonged exposure to estrogen and adrenal steroids. Identifying the factors affecting obesity in women who experience early menarche is essential for managing obesity in adult women. This study aimed to analyze the factors associated with obesity in adult women who experienced early menarche and to provide basic data for obesity management. This study was a cross-sectional and descriptive survey from the seventh Korea National Health and Nutrition Examination. A total of 371 women aged ≥ 19 years experienced early menarche, and the propensity matching method was used to analyze the obesity-related factors identified in previous studies. The results showed that obesity in adult women with early menarche was negatively associated with the level of aerobic exercise (OR = 0.53, 95% CI = 0.30–0.93, p = 0.028) and muscle-strengthening exercise (OR = 0.33, 95% CI = 0.17–0.64, p = 0.001). Future longitudinal studies on girls who experience early menarche are needed to address female obesity prevention at every stage of life, and, based on these findings, obesity management programs can be developed and applied and their effectiveness determined.
Health Status and Activity Discomfort among Elderly Drivers: Reality of Health Awareness
Authors: Jeong Sang-Hoon , Kim Eun-Yeob , Lee Seung-Jin , Choi Woo-June , Oh Chilhwan , Sung Hwa-Jung , Kim Jaeyoung
Published: February 2023

As the number of elderly drivers rapidly increases worldwide, interest in the dangers of driving is growing as accidents rise. The purpose of this study was to conduct a statistical analysis of the driving risk factors of elderly drivers. In this analysis, data from the government organization’s open data were used for the secondary processing of 10,097 people. Of the 9990 respondents, 2168 were current drivers, 1552 were past drivers but were not driving presently, and 6270 did not have a driver’s license; the participants were divided into groups accordingly. The elderly drivers who were current drivers had a better subjective health status than those who were not. Visual and hearing aids were used in the current driving group, and their depression symptoms reduced as they drove. The elderly who were current drivers experienced difficulties while driving in terms of decreased vision, hearing loss, reduced arm/leg reaction speed, decreased judgment of the road conditions such as signals and intersections, and a decreased sense of speed. The results suggest that elderly drivers are unaware of the medical conditions that can negatively affect their driving. This study contributes to the safety management of elderly drivers by understanding their mental and physical status.
Study on the Relationship between Urban Street-Greenery Rate and Land Surface Temperature Considering Local Climate Zone
Authors: Wang Xinyue , Li Zhengrui , Ding Shuangxin , Sun Xiufeng , Qin Hua , Ji Jianwan , Zhang Rui
Published: February 2023

Relationship exploration between the street-greenery rate (SGR) of different street types and land surface temperature (LST) is of great significance for realizing regional sustainable development goals. Given the lack of consideration of the local climate zone concept (LCZ), Chongqing’s Inner Ring region was selected as a case to assess the relationship between SGR and LST. Firstly, the LST was retrieved based on Landsat 8 imagery, which was calibrated by the atmospheric correction method; next, the street-greenery rates of different streets were calculated based on the semantic segmentation method; finally, street types were classified in detail by introducing LCZ, and the relationship between SGR and LST was investigated. The results showed that: (1) The LST spatial distribution pattern was closely related to human activity, with the high-temperature zones mainly concentrated in the core commercial areas, dense residential areas, and industrial cluster areas; (2) The average SGR values of expressways, main trunk roads, secondary trunk roads, and branch roads were 21.70%, 22.40%, 24.60%, and 26.70%, respectively. The level of SGR will decrease when the street width increases; (3) There is a negative correlation between the SGR and the LST in most streets. Among them, the LST of secondary trunk roads in low-rise and low-density built-up areas with a south-north orientation had a strong negative correlation with the SGR. Moreover, the wider the street, the higher the cooling efficiency of plants. Specifically, the LST of streets in low-rise and low-density built-up areas with south-north orientation may decrease by 1°C when the street-greenery rate is increased by 3.57%.
Analysis of Non-Compulsory Influenza and COVID-19 Vaccination among Polish Soldiers
Authors: Ejchman-Pac Ewelina , Wójtowicz Julian , Zawadzka Magdalena
Published: February 2023

The COVID-19 pandemic posed many challenges in epidemiology, health care, and vaccinology. Pharmaceutical and biotechnology companies had to develop effective vaccines as soon as possible in order to halt the spread of infection outbreaks and enable the start of the National Vaccination Program. Firstly, medical services and security services (the army, fire brigade, and police), i.e., those most involved in the fight against the effects of the COVID-19 pandemic, were included in the aforementioned program. The presented publication analyzes the amount and type of vaccination against COVID-19 and influenza among Polish soldiers. Influenza, like COVID-19, is a viral disease that can vary in its course (from mild to acute and life-threatening). Both coronaviruses and influenza viruses are characterized by high genetic variability, resulting in the need for repeated vaccination during each autumn and winter season. Acquired data comes from the Central Register of Vaccination of Professional Soldiers. The collected material was statistically processed. The average level of the phenomenon was presented as a time series using a chronological average. In the analyzed period (December 2020–December 2021), the lowest vaccinations against COVID-19 were performed in December 2020, which is due to the schedule of the National Vaccination Program in Poland. In contrast, the highest number of vaccinations were administered between April and June 2021, or approximately 70.5% of all vaccines administered. In the case of influenza, there is a clear increase in the number of vaccinations during the autumn and winter seasons, which coincides with peaks in disease during these periods. Between August 2020 and January 2021, there is a noticeable increase in the number of flu injections given, nearly 50% compared to the previous period, which may be related to the simultaneous persistence of the COVID-19 pandemic and greater attention to one’s own health. Non-mandatory vaccination is an important point in the vaccination schedule for soldiers. Numerous public campaigns combating misinformation and raising awareness of the need for immunization will help convince even more people, not only among soldiers but also the civilian population, to vaccinate.
Radiofrequency Thermal Ablation for the Treatment of Chronic Insufficiency of the Saphenous Vein—A Comparative Retrospective Study
Authors: Andercou Octavian , Stancu Bogdan , Coman Horațiu Flaviu , Cucuruz Beatrix , Noppeney Thomas , Marian Dorin
Published: February 2023

Objectives: The broad spectrum of chronic venous disease encompasses varicose veins, edema, hyperpigmentation and venous ulcers. Radiofrequency thermal ablation is indicated for the treatment of superficial venous reflux of the lower limb. Our research is a comparative clinical study that aims to identify the most effective and safest therapeutic method in the management of chronic venous insufficiency of the lower limbs. Materials and methods: Patients admitted to the Department of Surgery of the University of Medicine and Pharmacy in Cluj-Napoca, Romania, with the clinical diagnosis of varicose veins of the lower limbs, treated by thermal ablation with radiofrequency or by open surgical techniques during the year 2022, were included. Results: A percentage of 50.9% of the patients were treated by the radiofrequency thermal ablation procedure and 49.1% by surgical treatment. More than half of them were hospitalized for 2 days. The duration of hospitalization was significantly longer in patients who had postoperative complications (p < 0.001). The chance of being treated by open surgical treatment for a small saphenous vein is 10.11 times higher than by radiofrequency thermal ablation. Conclusion: According to the applied tests, there is no statistical difference between the group treated by radiofrequency thermal ablation and the one surgically treated in terms of sex, age, origin, CEAP clinical stage at hospitalization, clinical diagnosis at hospitalization and affected lower limb.
Measurement Properties of Self-Report Questionnaires for Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis of Commonly Used Instruments
Authors: Sanchez-Andrades Maria Jose , Vinolo-Gil Maria Jesus , Casuso-Holgado María Jesús , Barón-López Javier , Rodríguez-Huguet Manuel , Martín-Valero Rocío
Published: February 2023

(1) Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. There is no evidence on the analysis of the measurement instruments available to assess quality of life in these patients, following the consensus-based standards for the selection of health measurement instruments (COSMIN) checklist; (2) Methods: A systematic review was performed in PubMed, Embase, PEDro, Web of Science and Cochrane. The psychometric properties of the questionnaires were determined by using the COSMIN checklist. Two searches were carried out. This systematic review was registered in PROSPERO (CRD42021249005); (3) Results: There were four published articles that analysed the measurement properties in patients with ALS for the following scales: Amyotrophic Lateral Sclerosis Assessment Questionnaire 40, Amyotrophic Lateral Sclerosis-Specific Quality of Life Questionnaire, Short Form 36 Healthy Survey, Epworth Sleepiness Scale and Sickness Impact Profile. Another five scales also met the inclusion criteria: ALS-Depression-Inventory, State Trait Anxiety-Inventory, World Health Organization Quality of Life, Schedule for the Evaluation of Individual Quality of Life, Amyotrophic Lateral Sclerosis Assessment Questionnaire 5. Most Patient Reported Outcome Measures (PROMs) present a low-quality synthesis of evidence. It was observed an excellent pooled reliability of 0.92 (95% Confidence Interval: 0.83–0.96, I2 = 87.3%) for four dimensions for questionnaires ALSAQ-40. (4) Conclusions: There is little evidence on generic instruments. Future studies are necessary to develop new tools.