bluuebunny/crossref_metadata_2025 huggingface dataset:
Quality of Relationships Between Residential Staff and Youth: A Systematic Review
Authors: Pinheiro Micaela , Magalhães Eunice , Calheiros Maria Manuela , Macdonald Diana
Published: December 2022

Regardless of the type of residential care context, entering in care is an impactful event that involves the separation of young people from their relatives, as well as the need to adapt to a new context. This adaptation might be facilitated by the quality of relationships with professionals in these settings, which in turn may positively impact young people’s psychological adjustment.

Purpose: The current systematic review aims to identify the factors that might be associated with quality relationships in residential homes (i.e., generalist care, therapeutic care, juvenile justice settings) at different ecological levels.

Method: A systematic electronic search was conducted in eight databases: Academic Search Complete, APA PsycArticles, APA PsycINFO, Psychology and Behavioral Sciences Collection, ERIC, MEDLINE, Web of Science and Scopus, using a combination of words related with quality relationship, residential care, children, and adolescent. Based on the PRISMA statement, 919 manuscripts were yielded, and thirteen studies met the inclusion criteria.

Results: Child (e.g., gender or age), professionals (e.g., professionals’ characteristics, behaviors, and skills), organizational (e.g., Ratios of children to professionals on staff) and cross-cutting factors (e.g., time spent together, length of relationship) were found to be associated with quality relationships between professionals and young people in care.

Discussion: The residential care settings should be able to provide appropriate resources and services which address young people’s complex needs. Practical implications are discussed.
National Climate Change Risk Assessments to inform adaptation policy priorities and environmental sustainability outcomes: a knowledge systems perspective
Authors: Brown Iain , Berry Pam
Published: December 2022

National Climate Change Risk Assessments (CCRAs) have a key role in informing priorities for adaptation policy but face significant challenges due to multiple facets of risk and adaptation. Issues are especially pronounced for meeting goals of environmental sustainability due to the complex dynamics of socio-ecological systems. In practice, a CCRA can therefore differ from its original conceptual blueprint. These challenges are explored from a knowledge systems perspective, focusing on the role of stakeholders/policymakers, risk descriptors, methods, evidence sources, and scientists. A UK case study evaluates recent developments (CCRA3) including identification of policy urgency through adaptation shortfalls and its application to the natural environment. Important science-policy issues are also highlighted regarding inclusion of opportunities, systemic risks, residual risks, and risk tolerance. A general conclusion is that CCRAs inevitably leave open questions which lead back to their evolving role in the science-policy interface. A knowledge systems perspective identifies CCRAs as open, adaptive, reflexive processes that help redefine interpretations of risk and adaptation, rather than just providing a specific policy-relevant product. This perspective identifies scope for progressive refinement of CCRAs to enhance collective science-policy adaptive capacity whilst also engaging wider society. For environmental sustainability, this open process can be used to iteratively redefine robust future pathways and system reference conditions that also better reflect evolving societal perceptions and tolerance on sustainability risk in the face of climate change.
Multi-level emulation of tsunami simulations over Cilacap, South Java, Indonesia
Authors: Ehara Ayao , Salmanidou Dimitra M. , Heidarzadeh Mohammad , Guillas Serge
Published: December 2022

Carrying out a Probabilistic Tsunami Hazard Assessment (PTHA) requires a large number of simulations done at a high resolution. Statistical emulation builds a surrogate to replace the simulator and thus reduces computational costs when propagating uncertainties from the earthquake sources to the tsunami inundations. To reduce further these costs, we propose here to build emulators that exploit multiple levels of resolution and a sequential design of computer experiments. By running a few tsunami simulations at high resolution and many more simulations at lower resolutions we are able to provide realistic assessments whereas, for the same budget, using only the high resolution tsunami simulations do not provide a satisfactory outcome. As a result, PTHA can be considered with higher precision using the highest spatial resolutions, and for impacts over larger regions. We provide an illustration to the city of Cilacap in Indonesia that demonstrates the benefit of our approach.
Isolation and endemism in the subterranean aquatic snails of the genus Belgrandiella A. J. Wagner, 1928 (Caenogastropoda: Truncatelloidea: Hydrobiidae)
Authors: Jaszczyńska Aleksandra , Falniowski Andrzej , Prevorčnik Simona , Osikowski Artur , Hofman Sebastian
Published: December 2022

The Western Balkans hosts the richest subterranean aquatic gastropod fauna in the world. The main factors shaping intraspecies diversity are thought to be isolation and endemism. In the genusBelgrandiella, minute snails inhabiting subterranean waters and springs in Central Europe and Balkans, molecular studies have shown much fewer valid species than previously anticipated. The present study applies mitochondrial cytochrome c oxidase subunit I, histone 3, and RAPD analysis, to check the inter- and intraspecies genetic diversity in 36Belgrandiellapopulations from caves, springs and interstitial aquifers. The level of gene flow is assessed to check if these snails form a widespread genetically uniform metapopulation or rather follow the highly endemic pattern. The studied populations have been assigned to six species. In the most widely distributedB. kuscerifrom 21 populations, 60 sequenced specimens represent 16 haplotypes. While the same haplotypes are present in distant populations, gene flow between the other populations is low. Nei distances for RAPD show no geographic pattern. The interspecies differences in COI evidently confirm the time of speciation in Pleistocene, before karstification, which rejects speciation within isolated caves. The pattern observed inBelgrandiellaseems more similar to the one described inMontenegrospeumthan inKerkia.
“Burning Villages”: Leo Katz’s Novels on the 1907 Romanian Peasants’ Revolt and the Question of Antisemitism
Authors: Kaltenbrunner Andreea
Published: December 2022

This article explores the Jewish question in the context of the 1907 Romanian Peasants’ Revolt through the novels of the Austrian Jewish communist Leo Katz. Katz witnessed the uprising as a youth from his native village situated on the border between the Habsburg Empire, Romania, and Tsarist Russia. He wrote two novels about the revolt: one in 1940 and the other in 1946. The present study examines the violent clashes that unfolded at the border and how the writer approached the concept of antisemitism in the context of the revolt. Relying mainly on Katz’s personal papers, the article shows that Katz’s understanding of antisemitism was related to his communist beliefs. This changed following debates on antisemitism that he and other German-speaking communists had while in exile in Mexico, where Katz spent most of World War Il. Although Katz includes more details on antisemitism in his second novel, he does not address the anti-Jewish violence perpetrated by the rural masses, which is an aspect otherwise well documented by the Austro-Hungarian border authorities. Katz’s novels are the most comprehensive Jewish narratives on the 1907 Romanian Peasants’ Revolt and represent a Jewish intellectual’s struggle to make sense of the rising antisemitism in that tri-border area at the turn of the twentieth century.
A Turn-On–Type Fluorescence Resonance Energy Transfer Eco-friendly Method for Nitazoxanide Quantification in Pharmaceutical Dosage Form and Spiked Plasma: Evaluation of Greenness Profile Using Different Assessment Tools
Authors: Mostafa Eman A. , Elkady Ehab F. , El-Didamoony Mai A. , Batakoushy Hany A.
Published: December 2022

A brand-new class of anti-infective drugs that work against bacteria, viruses, and protozoan parasites is nitazoxanide and related thiazolides. Thiazolides have also been shown to cause cell cycle arrest and apoptotic cell death in cancer cells in recent years. In this study, an eco-friendly, spectrofluorimetric technique that is verified, easy, and sensitive has been proposed for quantifying nitazoxanide (NTZ), a broad-spectrum antiparasitic drug. When NTZ is reduced with zinc (Zn) powder in an acidic media, a highly fluorescent product is produced. To get the highest sensitivity, different experimental conditions impacting the response were examined and optimized. Following excitation at 299 nm, scanning of the fluorescent product was done at 440 nm. The intensity of the fluorescence was proportional to the drug concentration in the range of 0.1–0.6 μg/mL. The approach was validated according to International Conference on Harmonization (ICH) guidelines, and the outcome was satisfactory. The detection and quantitation limits were calculated to be 0.013 and 0.038 μg/mL, respectively. The suggested technique was successful in analyzing commercially available NTZ dosage forms. Furthermore, the proposed technique was used to assess NTZ levels in human plasma and it was bio-analytically validated according to European Medicines Agency (EMA) guidelines. The suggested method can be used in quality control laboratories as well as in pharmacokinetic studies. In order to picture the green profile of the developed method, four greenness assessment tools have been applied. National Environmental Methods Index (NEMI), analytical Eco-Scale Assessment (ESA), Green Analytical Procedure Index (GAPI) and Analytical Greenness metric (AGREE) are the relatively most widely used metrics. So, they were utilized to perform a detailed greenness comparison between the proposed method and some of the reported methods for the determination of NTZ. The developed method was found to be an excellent green method with the highest AGREE score.
Hidden attractors in Chua circuit: mathematical theory meets physical experiments
Authors: Kuznetsov Nikolay , Mokaev Timur , Ponomarenko Vladimir , Seleznev Evgeniy , Stankevich Nataliya , Chua Leon
Published: December 2022

After the discovery in early 1960s by E. Lorenz and Y. Ueda of the first example of a chaotic attractor in numerical simulation of a real physical process, a new scientific direction of analysis of chaotic behavior in dynamical systems arose. Despite the key role of this first discovery, later on a number of works have appeared supposing that chaotic attractors of the considered dynamical models are rather artificial, computer-induced objects, i.e., they are generated not due to the physical nature of the process, but only by errors arising from the application of approximate numerical methods and finite-precision computations. Further justification for the possibility of a real existence of chaos in the study of a physical system developed in two directions. Within the first direction, effective analytic-numerical methods were invented providing the so-called computer-assisted proof of the existence of a chaotic attractor. In the framework of the second direction, attempts were made to detect chaotic behavior directly in a physical experiment, by designing a proper experimental setup. The first remarkable result in this direction is the experiment of L. Chua, in which he designed a simple RLC circuit (Chua circuit) containing a nonlinear element (Chua diode), and managed to demonstrate the real evidence of chaotic behavior in this circuit on the screen of oscilloscope. The mathematical model of the Chua circuit (further, Chua system) is also known to be the first example of a system in which the existence of a chaotic hidden attractor was discovered and the bifurcation scenario of its birth was described. Despite the nontriviality of this discovery and cogency of the procedure for hidden attractor localization, the question of detecting this type of attractor in a physical experiment remained open. This article aims to give an exhaustive answer to this question, demonstrating both a detailed formulation of a radiophysical experiment on the localization of a hidden attractor in the Chua circuit, as well as a thorough description of the relationship between a physical experiment, mathematical modeling, and computer simulation.
Surgical Treatment of Craniopharyngiomas in Adults: Comparison between Primary Surgery and Surgery for Recurrence
Authors: Zamora Rocío Evangelista , Grimm Florian , Adib Sasan Darius , Bornemann Antje , Honegger Jürgen
Published: December 2022

Objective

Few studies have investigated the differences in outcomes between primary and repeat surgery for a craniopharyngioma in adults. As a result, a treatment concept for adult patients with a craniopharyngioma has not yet been established. The present study aimed to retrospectively analyze adult patients with craniopharyngioma to compare surgical outcomes between primary surgery and surgery for recurrence.

Methods

The demographic and clinical data of 68 adult patients with craniopharyngioma who had primary surgery (n=50) or surgery for recurrence (n=18) were retrospectively analyzed. In addition, the patients were followed up for an average of 38.6 months (range: 1–133 months).

Results

The cohorts of patients undergoing primary surgery or repeat surgery did not differ preoperatively in terms of demographic data, or radiological tumor features. However, patients with recurrent craniopharyngioma had significantly more pituitary hormone deficits and hypothalamo-pituitary disorders before surgery compared with patients with newly diagnosed craniopharyngioma. The success rate of complete resection in primary surgery was 53.2%. Even after repeat surgery, a satisfactory rate of complete resection of 35.7% was achieved. Operative morbidity was increased neither in patients with repeat surgery compared with those with primary surgery (postoperative bleeding P=0.560; meningitis P=1.000; CSF leak P=0.666; visual disturbance P=0.717) nor in patients with complete resection compared with those with partial resection. We found no difference in recurrence-free survival between initial surgery and repeat surgery (P=0.733). The recurrence rate was significantly lower after complete resection (6.9%) than after partial resection (47.8%; P<0.001).

Conclusion

Attempting complete resection is justified for not only those with newly diagnosed craniopharyngioma but also for those with recurrent craniopharyngioma. However, the surgeon must settle for less than total resection if postoperative morbidity is anticipated.
Approaches and outcomes of Robotic-Assisted Thoracic Surgery (RATS) for lung cancer: a narrative review
Authors: Mattioni Giovanni , Palleschi Alessandro , Mendogni Paolo , Tosi Davide
Published: December 2022

Robotic-Assisted Thoracic Surgery (RATS) is considered one of the main issues of present thoracic surgery. RATS is a minimally invasive surgical technique allowing enhanced view, accurate and complex movements, and high ergonomics for the surgeon. Despite these advantages, its application in lung procedures has been limited, mainly by its costs. Since now many different approaches have been proposed and the experience in RATS for lungs ranges from wedge resection to pneumonectomy and is mainly related to lung cancer. The present narrative review explores main approaches and outcomes of RATS lobectomy for lung cancer. A non-systematic review of literature was conducted using the PubMed search engine. An overview of lung robotic surgery is given, and main approaches of robotic lobectomy for lung cancer are exposed. Initial experiences of biportal and uniportal RATS are also described. So far, retrospective analysis reported satisfactory robotic operative outcomes, and comparison with VATS might suggest a more accurate lymphadenectomy. Some Authors might even suggest better perioperative outcomes too. From an oncological standpoint, no definitive prospective study has yet been published but several retrospective analyses report oncological outcomes comparable to those of VATS and open surgery. Literature suggests that RATS for lung procedures is safe and effective and should be considered as a valid additional surgical option.
Relatively Bounded Perturbations of J-Non-Negative Operators
Authors: Philipp Friedrich
Published: December 2022

We improve known perturbation results for self-adjoint operators in Hilbert spaces and prove spectral enclosures for diagonally dominant J-self-adjoint operator matrices. These are used in the proof of the central result, a perturbation theorem for J-non-negative operators. The results are applied to singular indefinite Sturm-Liouville operators with $$L^p$$

L
p

-potentials. Known bounds on the non-real eigenvalues of such operators are improved.
A study on the chemical profile and the derived health effects of heavy-duty machinery aerosol with a focus on the impact of alternative fuels
Authors: Gawlitta Nadine , Orasche Jürgen , Geldenhuys Genna-Leigh , Jakobi Gert , Wattrus Mark , Jennerwein Maximilian , Michalke Bernhard , Gröger Thomas , Forbes Patricia , Zimmermann Ralf
Published: December 2022

The combustion of petroleum-based fossil fuels is associated with a high environmental burden. Several alternative fuels, including synthetic fuels (e.g., gas-to-liquid, GTL) and biofuels (e.g., rapeseed methyl ester, RME) have been studied in the last few years. While the advantages for the environment (sustainability of biofuels) are well known, research on the resulting health effects from combustion aerosols of these alternative fuels is still scarce. Consequently, we investigated the chemical combustion profile from three distinct fuel types, including a petroleum-based fossil fuel (B0) and two alternative fuels (GTL, RME) under real exposure conditions. We sampled particulate matter (PM2.5, PM0.25) and the gas phase from heavy-duty machinery and evaluated the general pattern of volatile and semi-volatile organic compounds, elemental and organic carbon as well as a range of transition metals in the size segregated PM and/or gas phase. The use of comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry enabled us to classify distinct methylated PAHs in the PM samples and its high abundance, especially in the fine fraction of PM. We found that (methylated) PAHs were highly abundant in the PM of B0 compared to GTL and RME. Highest concentrations of targeted aromatic species in the gas phase were released from B0. In summary, we demonstrated that GTL and RME combustion released lower amounts of chemical compounds related to adverse health effects, thus, the substitution of petroleum-based fuels could improve air quality for human and the environment.
2D and 3D visualization of aquifer sediments, surface water seepage and groundwater flow using DC-resistivity, DC-IP, and SP methods, West El-Minia, Egypt
Authors: Ammar A. I. , Kamal K. A. , El-Boghdady M. F. M. , Ebrahem O.
Published: December 2022

In this study, the SP, DC-Resistivity and DC-TDIP methods were used and included 21 sites for determining the groundwater conditions and visualizing the aquifer sediments, surface water seepage, and groundwater flow in 2D and 3D. The results indicated the occurrence of Quaternary and Tertiary deposits, as well as shallow aquifer of Eocene fractured limestone and Quaternary deposits. The resistivity, chargeability and SP values were compared with each other and 2D and 3D visualization models were designed for these values to understand the sediment distribution and its geological and hydrogeological implications. High to medium, low and very low chargeability values indicated the compact sediments with high shale content, water-bearing layers and freshwater zones and dry sediments, respectively, and varied with the water amount, salinity and effective porosity. Low to very low values of SP indicated the occurrence and high accumulation of groundwater and an increase in shale, permeability and groundwater flow and source, and possibly salinity. The results showed that the resistivity, chargeability and SP values had an important role in separating the dry and saturated sediments and defining the fault zone, determining the source of surface water seepage, classifying the depths of high, medium and low groundwater accumulation and flow and permeability. The IP depended highly on the water amount and shale content and it was interesting in groundwater exploration with resistivity and in differentiating between groundwater and clays. The SP assisted in delineating the surface water seepage and groundwater source and flow direction, and predicting the sediments permeability.
Design optimization of cross-counter flow compact heat exchanger for energy recovery ventilator
Authors: Kim Won Seok
Published: December 2022

Energy recovery ventilators (ERVs) are the key equipment to fresh air ventilation, which is helpful for the control of respiratory diseases like COVID-19. In this paper, design optimization of the compact heat exchanger in a proposed heat recovery ventilator of the energy efficient building has been carried out and discussed. Appropriate theoretical models are required to evaluate system performance and potential energy savings. This is challenging because of the complexity of the preferred module combining cross- and counter-flow regions. The objective of the design optimization is to maximize the heat transfer effectiveness and to minimize the pressure loss of the compact heat exchanger with limited space. In this study, the allowable dimensions, heat transfer specifications and design requirements of the proposed heat exchanger are firstly defined. Then, the flow configuration, numbers, and dimensions of the air flow channels inside the heat exchanger are identified as the design parameters. A systematic design and optimization method for heat exchanger effectiveness improvement is explored. Furthermore, a detailed mathematical modeling is conducted and validated against the experimental results using the effectiveness-NTU method. It is found that the proposed modeling method is expected to be used to design of the compact heat exchanger. Finally, guidelines for improving the heat transfer effectiveness of air-to-air heat recovery ventilator were derived.
Asymptomatic screening for severe acute respiratory coronavirus virus 2 (SARS-CoV-2) as an infection prevention measure in healthcare facilities: Challenges and considerations
Authors: Talbot Thomas R. , Hayden Mary K. , Yokoe Deborah S. , Malani Anurag N. , Amer Hala A. , Kalu Ibukunoluwa C. , Logan Latania K. , Moehring Rebekah W. , Munoz-Price Silvia , Palmore Tara N. , Weber David J. , Wright Sharon B. ,   for the SHEA Board of Trustees
Published: December 2022

Executive summary

Testing of asymptomatic patients for severe acute respiratory coronavirus virus 2 (SARS-CoV-2) (ie, “asymptomatic screening) to attempt to reduce the risk of nosocomial transmission has been extensive and resource intensive, and such testing is of unclear benefit when added to other layers of infection prevention mitigation controls. In addition, the logistic challenges and costs related to screening program implementation, data noting the lack of substantial aerosol generation with elective controlled intubation, extubation, and other procedures, and the adverse patient and facility consequences of asymptomatic screening call into question the utility of this infection prevention intervention. Consequently, the Society for Healthcare Epidemiology of America (SHEA) recommends against routine universal use of asymptomatic screening for SARS-CoV-2 in healthcare facilities. Specifically, preprocedure asymptomatic screening is unlikely to provide incremental benefit in preventing SARS-CoV-2 transmission in the procedural and perioperative environment when other infection prevention strategies are in place, and it should not be considered a requirement for all patients. Admission screening may be beneficial during times of increased virus transmission in some settings where other layers of controls are limited (eg, behavioral health, congregate care, or shared patient rooms), but widespread routine use of admission asymptomatic screening is not recommended over strengthening other infection prevention controls. In this commentary, we outline the challenges surrounding the use of asymptomatic screening, including logistics and costs of implementing a screening program, and adverse patient and facility consequences. We review data pertaining to the lack of substantial aerosol generation during elective controlled intubation, extubation, and other procedures, and we provide guidance for when asymptomatic screening for SARS-CoV-2 may be considered in a limited scope.
Pointwise Assouad dimension for measures
Authors: Anttila Roope
Published: December 2022

We introduce a pointwise variant of the Assouad dimension for measures on metric spaces, and study its properties in relation to the global Assouad dimension. We show that, in general, the value of the pointwise Assouad dimension may differ from the global counterpart, but in many classical cases, the pointwise Assouad dimension exhibits similar exact dimensionality properties as the classical local dimension, namely it equals the global Assouad dimension almost everywhere. We also prove an explicit formula for the Assouad dimension of certain invariant measures with place-dependent probabilities supported on self-conformal sets.
How prevalent is a cancer-protective lifestyle? Adherence to the 2018 World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations in Switzerland
Authors: Karavasiloglou Nena , Pestoni Giulia , Pannen Sarah Theresa , Schönenberger Katja Angela , Kuhn Tilman , Rohrmann Sabine
Published: December 2022

Population monitoring of lifestyle behaviours that are crucial as risk and protective factors for major chronic diseases is vital for the identification of priority areas for public health. In this study, we aimed to investigate the prevalence of adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) cancer prevention recommendations in Switzerland, overall and by selected sociodemographic and lifestyle characteristics. Data from the population-based, cross-sectional survey menuCH were used. We constructed a score reflecting adherence to the 2018 WCRF/AICR cancer prevention recommendations. Multinomial logistic regression models were fitted to investigate the association of sociodemographic and lifestyle characteristics with the level of adherence to the WCRF/AICR cancer prevention recommendations. The least frequently met cancer prevention recommendations were the ones on fibre intake (met by 13·7 %), red and processed meat (25·4 %), and ultra-processed food (33·3 %) consumption, while the recommendation on physical activity was met by almost 80 %. Women and individuals with tertiary education were more likely to have a score of ≥ 5 (as a reflection of adherence to the cancer prevention recommendations), compared with men or those who completed secondary education, respectively. Current smokers were less likely to have a score of ≥ 5, compared with never smokers. A high proportion of the population in Switzerland was found to not adhere closely to the WCRF/AICR cancer prevention recommendations. Differences were detected based on sociodemographic characteristics. Education and policy actions are needed to facilitate the adoption of a cancer-protective lifestyle.
FP-injective dimensions and Gorenstein homology
Authors: Yang Gang , Wang Junpeng
Published: December 2022

Let $R$ be a left coherent ring. It is proven that if an $R$-module $M$ has a finite FP-injective dimension, then the Gorenstein projective (resp. Gorenstein flat) dimension and the projective (resp. flat) dimension coincide. Also, we obtain that the pair ($\mathcal {GP},\, \mathcal {GP}^{\perp }$) forms a projective cotorsion pair under some mild conditions.
Beyond playing 20 questions with nature: Integrative experiment design in the social and behavioral sciences
Authors: Almaatouq Abdullah , Griffiths Thomas L. , Suchow Jordan W. , Whiting Mark E. , Evans James , Watts Duncan J.
Published: December 2022

The dominant paradigm of experiments in the social and behavioral sciences views an experiment as a test of a theory, where the theory is assumed to generalize beyond the experiment's specific conditions. According to this view, which Alan Newell once characterized as “playing twenty questions with nature,” theory is advanced one experiment at a time, and the integration of disparate findings is assumed to happen via the scientific publishing process. In this article, we argue that the process of integration is at best inefficient, and at worst it does not, in fact, occur. We further show that the challenge of integration cannot be adequately addressed by recently proposed reforms that focus on the reliability and replicability of individual findings, nor simply by conducting more or larger experiments. Rather, the problem arises from the imprecise nature of social and behavioral theories and, consequently, a lack of commensurability across experiments conducted under different conditions. Therefore, researchers must fundamentally rethink how they design experiments and how the experiments relate to theory. We specifically describe an alternative framework, integrative experiment design, which intrinsically promotes commensurability and continuous integration of knowledge. In this paradigm, researchers explicitly map the design space of possible experiments associated with a given research question, embracing many potentially relevant theories rather than focusing on just one. Researchers then iteratively generate theories and test them with experiments explicitly sampled from the design space, allowing results to be integrated across experiments. Given recent methodological and technological developments, we conclude that this approach is feasible and would generate more-reliable, more-cumulative empirical and theoretical knowledge than the current paradigm – and with far greater efficiency.
Differential Relations Between Facets of Agreeableness and Ability-Based Measures of Strategic Emotional Intelligence
Authors: Hellwig Susan , Schulze Ralf
Published: December 2022

Abstract: Since classical intelligence factors are almost independent of personality, independence from personality is expected analogously for new intelligence factors, such as Emotional Intelligence (EI). However, performance tests of Strategic EI, in particular, consistently show a positive relationship with self-reports of Agreeableness which has not yet been the subject of more detailed investigations. This paper aims to elucidate this relationship with a focus on facet-level relationships. In a study with N = 176 participants, the correlations between two strategic EI measures on the one hand, and measures of the Big Five personality factors as well as the facets of Agreeableness, on the other hand, are estimated at the level of latent variables. The results suggest that the relationships vary markedly by the facet of Agreeableness. Strategic EI measures are specifically correlated with measures of Agreeableness facets that include agreeable behavior for which emotional abilities are required. Furthermore, the results indicate that the strength of relationships between EI measures with personality traits depends on the scoring procedures (consensus vs. theory-based scoring) used for tests of EI.
Early Adolescent Cognitive and Affective Empathy
Authors: Dillon-Owens Cody , Findley-Van Nostrand Danielle , Ojanen Tiina , Buchholz Christopher , Valdes Olivia
Published: December 2022

Abstract. Cognitive and affective empathy have diverging relations to social–emotional adjustment. However, particularly during adolescence, these associations are not thoroughly understood. Using the Basic Empathy Scale (BES), we examined cognitive and affective empathy (including emotional contagion and emotional disconnection) in association with social–emotional adjustment (negative affect, shyness, social self-efficacy, friendship quality, and peer victimization) in early adolescents ( N = 321). Cognitive empathy and emotional contagion showed divergent links (cognitive empathy was related to positive adjustment, while emotional contagion was related to negative adjustment but also higher friendship quality). Emotional disconnection was negatively associated with social self-efficacy, supporting affective empathy as having multiple factors itself. The findings further validate the BES as a three-factor measure and have implications for understanding social–emotional adjustment in youth.
The Effect of Pseudofrazil Particle Entrainment on Salinity Measurements
Authors: Richter Maren Elisabeth , Smith Inga J. , Everts Jonathan R. , Russell Peter , Langhorne Pat J. , Leonard Greg H.
Published: December 2022

Salinity effects of particles entrained into conductivity cells have previously mainly been studied in the context of suspended sediment. Particles influencing conductivity cells can also be small ice crystals (frazil) that may form in supercooled water. The detection of supercooled water depends on accurate, high precision temperature, salinity and pressure measurements. As it is currently not possible to measure salinity in situ, the standard procedure is to measure conductance over a known volume and calculate salinity. Frazil ice entrained into a conductivity cell changes the volume of conductive fluid in the conductivity cell, thus changing the conductivity, salinity and supercooling measurements. We present results on the effect of entraining microplastic into a Sea‐Bird Electronics conductivity cell to simulate the effect of frazil. We show that particle volumes comparable to frazil volumes observed in the ocean change the measured conductivity and led to changes in calculated supercooling between 0.3 and 10 mK, possibly up to the same order of magnitude as naturally observed supercooling in the ocean. Further, we demonstrate that where supercooling is present, natural frazil ice concentrations can have an appreciable effect on parameters calculated with both the Equation of State of Seawater 1980 and Thermodynamic Equation of Seawater 2010 equations of state of seawater. Thus, to ensure accurate measurements in locations of very high frazil concentration, the entrainment of frazil needs to be prevented, which is not possible with methods currently available, or corrected for. An example for such a correction is given and could be modified to be applicable to other particles, for example, sediment.
Bayesian Quantification and Reduction of Uncertainties in 3D Geomechanical‐Numerical Models
Authors: Ziegler Moritz O. , Heidbach Oliver
Published: December 2022

The distance to failure of the upper crustal rock in the prevalent stress field is of importance to better understand fault reactivation by natural and induced processes as well as to plan and manage georeservoirs. In particular, the contemporary stress state is one of the key ingredients for this assessment. To provide a continuous description of the 3D absolute stress state geomechanical‐numerical models are used. However, stress magnitude data for model calibration are sparse and incomplete and thus, the resulting model uncertainties are large. In order to reduce the uncertainties, we incorporate additional constraints on stress magnitudes to check the plausibility of different data‐based stress states. We use formation integrity tests, borehole breakouts, drilling induced fractures, and observations of seismicity and distinct seismological quiescence. This information is weighted according to its confidence and the agreement with the different modeled stress states is assessed. The information is introduced to a Bayesian approach to estimate weights of the modeled stress states and thereby identify their plausibility. A case study in southern Germany shows the ability of the approach to identify from a wide range of stress states a small number of plausible ones and reject implausible stress states. This significantly reduces the number of stress states and thus lowers the model uncertainties.
Lithospheric S Wave Velocity Variations Beneath the Mackenzie Mountains and Northern Canadian Cordillera
Authors: Schutt Derek L. , Porritt Robert W. , Estève Clément , Audet Pascal , Gosselin Jeremy M. , Schaeffer Andrew J. , Aster Richard C. , Freymueller Jeffrey T. , Cubley Joel F.
Published: December 2022

The Mackenzie Mountains (MMs) in the Yukon and Northwest Territories, Canada, are an enigmatic mountain range. They are currently uplifting (Leonard et al., 2008, https//doi.org/10.1029/2007JB005456), yet are about 700 km from the nearest plate boundary. Their arcuate shape is distinct and extends over 100 km eastward from the general trend of the Northern Canadian Cordillera. To better assess the cause and conditions of the current uplift, we processed ambient seismic noise data from a linear array of broadband seismographs crossing the mountains, along with other regional seismic stations, to estimate Rayleigh wave phase velocities between 6 and 40 s periods. From this, we estimated phase velocity dispersion and performed a tomographic inversion to estimate VS. Tomography reveals a low‐velocity structure that extends upward from the base of the ∼50–66 km thick lithosphere to the upper crust, and we hypothesize that inferred low density and low rigidity associated with the VS anomaly localizes the ongoing uplift and thrust‐dominated seismicity of the MMs. Additionally, we find relatively low crustal velocities that extend to the west of the MMs, suggesting that strain transfer from the Gulf of Alaska plate boundary plays a driving role as the crust translates to the northeast and buckles up against the craton consistent with the orogenic float hypothesis of Mazzotti and Hyndman (2002, https//doi.org/10.1130/0091-7613(2002)030〈0495:YCASTA〉2.0.CO;2). Finally, we observe lithospheric azimuthal anisotropy with an NW‐SE fast direction. This is nearly orthogonal to teleseismic shear wave splitting measurements in the central MMs, and suggests that asthenosphere flow and lithospheric strain are not aligned in this region.
Linking environmental injustices in Detroit, MI to institutional racial segregation through historical federal redlining
Authors: Shkembi Abas , Smith Lauren M. , Neitzel Richard L.
Published: December 2022

Objectives

To identify the most pervasive environmental exposures driving environmental disparities today associated with historical redlining in Detroit.

Methods

We overlaid Detroit’s 1939 Home Owners’ Loan Corporation (HOLC) shapefile from the Mapping Inequality project onto the EPA EJScreen and the DOT National Transportation Noise maps to analyze differences in current demographic and environmental indicators between historically redlined (D-grade) and non-redlined neighborhoods using simple linear regression and a boosted classification tree algorithm.

Results

Historically redlined neighborhoods in Detroit experienced significantly higher environmental hazards than non-redlined neighborhoods in the form of 12.1% (95% CI: 7.2–17.1%) higher levels of diesel particulate matter (PM), 32.2% (95% CI: 3.3–69.3%) larger traffic volumes, and 65.7% (95% CI: 8.6–152.8%) higher exposure to hazardous road noise (LEQ(24h) >70 dBA). Historically redlined neighborhoods were situated near 1.7-times (95% CI: 1.4–2.1) more hazardous waste sites and twice as many (95% CI: 1.5–2.7) risk management plan (RMP) sites than non-redlined neighborhoods. The lifetime cancer risk from inhalation of air toxics was 4.4% (95% CI: 2.9–6.6%) higher in historically redlined communities, and the risk of adverse respiratory health outcomes from air toxics was 3.9% (95% CI: 2.1–5.6%) higher. All factors considered together, among the environmental hazards considered, the most pervasive hazards in historically redlined communities are proximity to RMP sites, hazardous road noise, diesel PM, and cancer risk from air pollution.

Conclusions

Historically redlined neighborhoods may have a disproportionately higher risk of developing cancer and adverse respiratory health outcomes from air toxics. Policies targeting air and noise pollution from transportation sources, particularly from sources of diesel exhaust, in historically redlined neighborhoods may ameliorate some of the impacts of structural environmental racism from historical redlining in Detroit.
Functional investigation of SLC1A2 variants associated with epilepsy
Authors: Qu Qi , Zhang Wenlong , Wang Ji , Mai Dongmei , Ren Siqiang , Qu Shaogang , Zhang Yunlong
Published: December 2022

Epilepsy is a common neurological disorder and glutamate excitotoxicity plays a key role in epileptic pathogenesis. Astrocytic glutamate transporter GLT-1 is responsible for preventing excitotoxicity via clearing extracellular accumulated glutamate. Previously, three variants (G82R, L85P, and P289R) in SLC1A2 (encoding GLT-1) have been clinically reported to be associated with epilepsy. However, the functional validation and underlying mechanism of these GLT-1 variants in epilepsy remain undetermined. In this study, we reported that these disease-linked mutants significantly decrease glutamate uptake, cell membrane expression of the glutamate transporter, and glutamate-elicited current. Additionally, we found that these variants may disturbed stromal-interacting molecule 1 (STIM1)/Orai1-mediated store-operated Ca2+ entry (SOCE) machinery in the endoplasmic reticulum (ER), in which GLT-1 may be a new partner of SOCE. Furthermore, knock-in mice with disease-associated variants showed a hyperactive phenotype accompanied by reduced glutamate transporter expression. Therefore, GLT-1 is a promising and reliable therapeutic target for epilepsy interventions.
Tumor immune microenvironment and immunotherapy efficacy in BRAF mutation non-small-cell lung cancer
Authors: Li Hui , Zhang Yongchang , Xu Yanjun , Huang Zhiyu , Cheng Guoping , Xie Mingyin , Zhou Zichao , Yu Yangyang , Xi Wenjing , Fan Yun
Published: December 2022

Previous small-size studies reported BRAF-mutated NSCLC patients have comparable sensitivity to immune checkpoint inhibitors (ICIs). However, how BRAF mutation affects the tumor immune microenvironment (TIME) is unknown. We performed Nanostring-panel RNA sequencing to evaluate TIME in 57 BRAF mutated and wild-type (WT) NSCLC specimens (cohort A). The efficacy of ICI monotherapy or combined therapies was determined in 417 patients with WT and BRAF mutated NSCLC (cohort B). We found that BRAF-mutant tumors had similar ratios of CD8+ T cells to Tregs, the balance of cytotoxicity gene expression signatures and immune suppressive features, and similar ICI-response-related biomarkers to WT NSCLC. A similar TIME pattern was observed between the BRAF V600E and Non-V600E subgroups of NSCLC. The further retrospective study confirmed that treatment with ICI monotherapy or combined therapies resulted in similar overall survival (OS) (HR: 0.85; 95% CI, 0.56 to 1.30; p = 0.47) and progress-free survival (PFS) (HR: 1.02; 95% CI, 0.72 to 1.44; p = 0.91) of patients with WT (n = 358) and BRAF mutant (n = 59) NSCLC. Similarly, both patients with BRAF V600E or Non-V600E NSCLC had similar responses to immunotherapy. Our findings support that BRAF mutation did not modulate TIME in NSCLC and therapeutic responses to ICIs. Patients with NSCLC harboring BRAF mutation should not be denied treatment with ICIs.
SARS-CoV-2 vaccination-infection pattern imprints and diversifies T cell differentiation and neutralizing response against Omicron subvariants
Authors: Wang Junxiang , Li Kaiyi , Mei Xinyue , Cao Jinpeng , Zhong Jiaying , Huang Peiyu , Luo Qi , Li Guichang , Wei Rui , Zhong Nanshan , Zhao Zhuxiang , Wang Zhongfang
Published: December 2022

The effects of different SARS-CoV-2 vaccinations and variant infection histories on imprinting population immunity and their influence on emerging escape mutants remain unclear. We found that Omicron (BA.1) breakthrough infection, regardless of vaccination with two-dose mRNA vaccines (M-M-o) or two-dose inactivated vaccines (I-I-o), led to higher neutralizing antibody levels against different variants and stronger T-cell responses than Delta breakthrough infection after two-dose inactivated vaccine vaccination (I-I-δ). Furthermore, different vaccination-infection patterns imprinted virus-specific T-cell differentiation; M-M-ο showed higher S/M/N/E-specific CD4+ T cells and less portion of virus-specific CD45RA+CD27–CD8+ T cells by ex vivo assay. Breakthrough infection groups showed higher proliferation and multi-function capacity by in vitro assay than three-dose inactivated vaccine inoculated group (I-I-I). Thus, under wide vaccination coverage, the higher immunogenicity with the Omicron variant may have helped to eliminate the population of Delta variant. Overall, our data contribute to our understanding of immune imprinting in different sub-populations and may guide future vaccination programs.
Calcium-permeable channelrhodopsins for the photocontrol of calcium signalling
Authors: Fernandez Lahore Rodrigo G. , Pampaloni Niccolò P. , Schiewer Enrico , Heim M.-Marcel , Tillert Linda , Vierock Johannes , Oppermann Johannes , Walther Jakob , Schmitz Dietmar , Owald David , Plested Andrew J. R. , Rost Benjamin R. , Hegemann Peter
Published: December 2022

Channelrhodopsins are light-gated ion channels used to control excitability of designated cells in large networks with high spatiotemporal resolution. While ChRs selective for H+, Na+, K+ and anions have been discovered or engineered, Ca2+-selective ChRs have not been reported to date. Here, we analyse ChRs and mutant derivatives with regard to their Ca2+ permeability and improve their Ca2+ affinity by targeted mutagenesis at the central selectivity filter. The engineered channels, termed CapChR1 and CapChR2 for calcium-permeable channelrhodopsins, exhibit reduced sodium and proton conductance in connection with strongly improved Ca2+ permeation at negative voltage and low extracellular Ca2+ concentrations. In cultured cells and neurons, CapChR2 reliably increases intracellular Ca2+ concentrations. Moreover, CapChR2 can robustly trigger Ca2+ signalling in hippocampal neurons. When expressed together with genetically encoded Ca2+ indicators in Drosophila melanogaster mushroom body output neurons, CapChRs mediate light-evoked Ca2+ entry in brain explants.
Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation
Authors: Lim Ryan G. , Al-Dalahmah Osama , Wu Jie , Gold Maxwell P. , Reidling Jack C. , Tang Guomei , Adam Miriam , Dansu David K. , Park Hye-Jin , Casaccia Patrizia , Miramontes Ricardo , Reyes-Ortiz Andrea M. , Lau Alice , Hickman Richard A. , Khan Fatima , Paryani Fahad , Tang Alice , Ofori Kenneth , Miyoshi Emily , Michael Neethu , McClure Nicolette , Flowers Xena E. , Vonsattel Jean Paul , Davidson Shawn , Menon Vilas , Swarup Vivek , Fraenkel Ernest , Goldman James E. , Thompson Leslie M.
Published: December 2022

The complexity of affected brain regions and cell types is a challenge for Huntington’s disease (HD) treatment. Here we use single nucleus RNA sequencing to investigate molecular pathology in the cortex and striatum from R6/2 mice and human HD post-mortem tissue. We identify cell type-specific and -agnostic signatures suggesting oligodendrocytes (OLs) and oligodendrocyte precursors (OPCs) are arrested in intermediate maturation states. OL-lineage regulatorsOLIG1andOLIG2are negatively correlated with CAG length in human OPCs, and ATACseq analysis of HD mouse NeuN-negative cells shows decreased accessibility regulated by OL maturation genes. The data implicates glucose and lipid metabolism in abnormal cell maturation and identifyPRKCEand Thiamine Pyrophosphokinase 1 (TPK1) as central genes. Thiamine/biotin treatment of R6/1 HD mice to compensate forTPK1dysregulation restores OL maturation and rescues neuronal pathology. Our insights into HD OL pathology spans multiple brain regions and link OL maturation deficits to abnormal thiamine metabolism.