bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Olefin Preparation via Palladium‐Catalyzed Oxidative De‐Azotative and De‐Sulfitative Internal Cross‐Coupling of Sulfonylhydrazones.
Authors: Tan Hongyu , Houpis Ioannis , Liu Renmao , Wang Youchu , Chen Zhilong
Published: October 2015

Highly substituted aromatic olefins are obtained by a new, effective, and atom‐economical intramolecular cross‐coupling reaction of the corresponding electron‐rich aromatic sulfonylhydrazones involving a formal extrusion of SO2 and N2.
ChemInform Abstract: A Nano Tetraimine Pd(0) Complex: Synthesis, Characterization, Computational Studies and Catalytic Applications in the Heck—Mizoroki Reaction in Water.
Authors: Mandegani Zeinab , Asadi Mozaffar , Asadi Zahra , Mohajeri Afshan , Iranpoor Nasser , Omidvar Akbar
Published: October 2015

A newly synthesized nano tetraimine Pd(0) complex (PTIC) is used as an efficient catalyst in Heck—Mizoroki reactions to afford a series of (het)aryl alkenes.
ChemInform Abstract: A Detachable Ester Bond Enables Perfect Z‐Alkylations of Olefins for the Synthesis of Tri‐ and Tetrasubstituted Alkenes.
Authors: Nishikata Takashi , Nakamura Kimiaki , Inoue Yuki , Ishikawa Shingo
Published: October 2015

The esterification‐alkylation reaction of vinyl phenols (I) with bromides (II) gives rise to lactones (III), which are converted into Z‐alkylated styrenes (IV) after hydrolysis.
ChemInform Abstract: A Bimetallic Iridium(II) Catalyst: [{Ir(IDipp)(H)}2][BF4]2 (IDipp = 1,3‐bis(2,6‐diisopropylphenylimidazol‐2‐ylidene))
Authors: Rubio‐Perez Laura , Iglesias Manuel , Munarriz Julen , Polo Victor , Sanz Miguel Pablo J. , Perez‐Torrente Jesus J. , Oro Luis A.
Published: October 2015

is used for the hydroalkynylation of imines
ChemInform Abstract: The Coupling Reactions of Aryl Halides and Phenols Catalyzed by Palladium and MOP‐Type Ligands.
Authors: Zhang Yi , Ni Gang , Li Chengjun , Xu Sheng , Zhang Zhaoguo , Xie Xiaomin
Published: October 2015

Optimized reactions conditions are developed for the Pd‐catalyzed coupling of aryl halides and phenols.
ChemInform Abstract: Rhodium‐Catalyzed Synthesis of Aryl Ketones from Carboxylic Acid Anhydrides and Potassium Aryltrifluoroborates in the Presence of CuI.
Authors: Liu Xia , Yi Ze , Yi Maocong , Wang Jianhui , Liu Guiyan
Published: October 2015

Aliphatic carboxylic anhydrides do not react with potassium phenyltrifluoroborate under the reaction conditions.
ChemInform Abstract: Metal Free Sulfenylation of Active Methylene Compounds and Indole: TBATB Mediated Synthesis.
Authors: Rahaman Rajjakfur , Devi Namita , Barman Pranjit
Published: October 2015

Various diaryldisulfides as well as diethyldisulfide are used as sulfenylating agents according to the title reaction providing the products in high yields.
ChemInform Abstract: Di‐ and Tri‐Nuclear‐Palladium Complexes Bearing Piperidoimidazolin‐2‐ylidenes: Synthesis, Characterization, and Catalytic Applications.
Authors: Tuerkmen Guelsah , Atik Aylin , Sahin Zarife Sibel , Tuerkmen Hayati
Published: October 2015

A trinuclear palladium N‐heterocyclic carbene complex is found to efficiently catalyze Heck‐coupling reactions of styrene with aryl bromides and Suzuki—Miyaura couplings of phenylboronic acid with aryl chlorides.
ChemInform Abstract: Nickel‐Catalyzed Dual C—C σ Bond Activation to Construct Carbocyclic Skeletons.
Authors: Nakai Kenichiro , Kurahashi Takuya , Matsubara Seijiro
Published: October 2015

Terminal alkynes fail in this reaction due to oligomerization.
ChemInform Abstract: Gold(I)‐Catalyzed Selective Heterocyclization of Propargylic Thioureas: Mechanistic Study of Competitive Gold‐Activation Mode.
Authors: Jiang Yu , Wei Yin , Tang Xiang‐Ying , Shi Min
Published: October 2015

A new selective gold(I)‐catalyzed intramolecular heterocyclization of homopropargylic isothiocyanates, erroneously named propargylic thioureas, is developed, efficiently affording two kinds of cycloadducts in moderate to excellent yields with a broad substrate scope.
ChemInform Abstract: Phosphine‐Catalyzed Diastereoselective Synthesis of β‐Lactones from Disubstituted Ketenes and α‐Chiral Oxyaldehydes.
Authors: Mondal Mukulesh , Chen Shi , Othman Nabil , Wheeler Kraig A. , Kerrigan Nessan J.
Published: October 2015

Cyclization of ketenes with glyceraldehyde acetonides gives β‐lactones diastereoselectively.
ChemInform Abstract: An Unexpected Thermal [1,3]‐[1,3]‐para Rearrangement of Chromone‐3‐ylmethyl Aryl Ethers: Mechanism and Application of the Intercepted [1,3]‐Rearranged Intermediates to the Synthesis of cis‐Homopterocarpans.
Authors: Devarajan Krishnan , Devaraj Somasundaram , Balasubramanian Kalpattu K , Bhagavathy Shanmugasundaram
Published: October 2015

Chromone‐3‐ylmethyl aryl ethers (I) undergo a novel domino [1,3]‐[1,3]‐rearrangement to give 4′‐hydroxyhomoisoflavones (II) under thermal conditions whereas, the para‐substituted ethers (IV) lead to 2′‐hydroxyhomoisoflavones instead of the expected Claisen rearrangement.
ChemInform Abstract: Highly Efficient Regioselective Synthesis of Pyrroles via a Tandem Enamine Formation—Michael Addition—Cyclization Sequence under Catalyst‐ and Solvent‐Free Conditions.
Authors: Vivekanand Thavaraj , Vinoth Perumal , Agieshkumar B. , Sampath Natarajan , Sudalai Arumugam , Menendez J. Carlos , Sridharan Vellaisamy
Published: October 2015

A convenient catalyst‐free, three‐component procedure is developed for the synthesis of tetrasubstituted pyrroles under solvent‐free conditions and in green solvents glycerol, PEG‐200 and water.
ChemInform Abstract: “On Water” Direct Catalytic Vinylogous Henry (Nitroaldol) Reactions of Isatins for the Efficient Synthesis of Isoxazole Substituted 3‐Hydroxyindolin‐2‐ones.
Authors: Zhang Yong , Wei Biao‐Wen , Lin Hui , Zhang Ling , Liu Jin‐Xiang , Luo Hai‐Qing , Fan Xiao‐Lin
Published: October 2015

A highly efficient and environmentally benign access to medicinally important isoxazole‐substituted 3‐hydroxy‐2‐oxindole derivatives by a new direct vinylogous Henry addition of dialkyl‐4‐nitroisoxazoles to isatins is described.
ChemInform Abstract: Enantioselective Synthesis of 3‐Fluoro‐3‐allyl‐oxindoles via Phosphine‐Catalyzed Asymmetric γ‐Addition of 3‐Fluoro‐oxindoles to 2,3‐Butadienoates.
Authors: Wang Tianli , Hoon Ding Long , Lu Yixin
Published: October 2015

The addition product can be easily converted into the 3‐allyl substituted oxindole derivative (V).
ChemInform Abstract: Catalytic Intramolecular Decarbonylative Coupling of 3‐Aminocyclobutenones and Alkenes: A Unique Approach to [3.1.0] Bicycles.
Authors: Zhou Xuan , Zafar Imran , Dong Guangbin
Published: October 2015

N‐but‐2‐enyl‐ and N‐but‐3‐enyl‐substituted substrates do not give the desired product.
ChemInform Abstract: Iron‐Catalyzed Diastereoselective Intramolecular Olefin Aminobromination with Bromide Ion.
Authors: Tian Jun‐Shan , Zhu Cheng‐Liang , Chen Yun‐Rong , Xu Hao
Published: October 2015

The new method is suitable for both internal and terminal olefins and provides a convenient approach to vicinal bromo primary amines.
ChemInform Abstract: Microwave Assisted Azide—Alkyne Cycloaddition Reaction Using Polymer Supported Cu(I) as a Catalytic Species: A Solventless Approach.
Authors: Taher Abu , Nandi Debkumar , Islam Rafique Ul , Choudhary Meenakshi , Mallick Kaushik
Published: October 2015

Newly synthesized polymer supported copper(I) composite is used as an effective catalyst for a 1,3‐dipolar cycloaddition reaction between terminal alkynes and azides to synthesize 1,2,3‐triazoles with excellent yields using a microwave irradiation technique in the absence of any solvent.
ChemInform Abstract: Gold‐Catalyzed Selective Oxidation of 4‐Oxahepta‐1,6‐diynes to 2H‐Pyran‐3(6H)‐ones and Chromen‐3(4H)‐ones via β‐Gold Vinyl Cation Intermediates.
Authors: Ji Kegong , Liu Xiang , Du Bowen , Yang Fang , Gao Jinming
Published: October 2015

The title reaction leads to pyranones (II), and benzochromenones (IV) in the presence of 2 mol% catalyst loading.
ChemInform Abstract: Carbonyl Olefination of Diaryl Ketones with Heteroaryl Sulfoxides.
Authors: Gao Bing , Hu Jingyu , Zhao Yanchuan , Hu Jinbo
Published: October 2015

Hitherto unknown Julia—Kocienski type olefination reactions of 2‐pyridyl sulfoxides and 1,3‐benzothiazol‐2‐yl sulfoxides are described.
ChemInform Abstract: Organocatalytic Asymmetric Intramolecular aza‐Henry Reaction: Facile Synthesis of trans‐2,3‐Disubstituted Tetrahydroquinolines.
Authors: Maity Rajendra , Pan Subhas Chandra
Published: October 2015

The products are obtained in high yields and with moderate enantioselectivities with the latter being significantly improved by recrystallization.
ChemInform Abstract: Single Step Incorporation of Carboxylic Acid Groups in the Lower Rim of Calix[4]arenes: A Recyclable Catalyst Towards Assembly of Diverse Five Ring Fused Acridines.
Authors: Sarkar Piyali , Mukhopadhyay Chhanda
Published: October 2015

New calix[4]arene grafted tricarboxylic acid is employed as an recyclable organocatalyst for the environmentally benign synthesis of substituted five ring‐fused acridine derivatives by the reaction of isatins with dimedone, alkyl/aryl amines, and diethyl acetylenedicarboxylate in PEG/H2O.
ChemInform Abstract: Efficient Approach to Mesoionic Triazolo[5,1‐a]isoquinolium Through Rhodium‐Catalyzed Annulation of Triazoles and Internal Alkynes.
Authors: Zhao Shixian , Yu Ruicheng , Chen Wanzhi , Liu Miaochang , Wu Huayue
Published: October 2015

Depending on the additive, 4‐aryltriazoles (I) are either annelated to the title compounds or vinylated at both ortho positions of the arene moiety relative to the triazole residue.
ChemInform Abstract: Synthesis of gem‐Bis‐phosphonates with (3‐Aryl‐4,5‐dihydroisoxazol‐5‐yl)methylamino Moiety.
Authors: Brel Valery K.
Published: October 2015

Title compounds (VI) with two pharmacophore sites, aminomethylene 1,1‐bisphosphonate fragment and 3‐arylisoxazoline moiety, are synthesized in good yields by a simple method.
ChemInform Abstract: New Limonoids from the Seeds of Xylocarpus granatum
Authors: Shi Qing‐Wen , et al.
Published: October 2015

isolation and structure of the novel limonoids (I)—(III)
ChemInform Abstract: Palladium‐Catalyzed Oxidative Synthesis of Highly Functionalized Ortholactones.
Authors: Baddeley Kate L. , Cao Qun , Muldoon Mark J. , Cook Matthew J.
Published: October 2015

A palladium‐catalyzed oxidative reaction is reported which converts dihydropyrans to their corresponding ortholactone.
ChemInform Abstract: Direct Staudinger—Phosphonite Reaction Provides Methylphosphonamidates as Inhibitors of CE4 De‐N‐Acetylases.
Authors: Ariyakumaran Rishikesh , Pokrovskaya Varvara , Little Dustin J. , Howell P. Lynne , Nitz Mark
Published: October 2015

6 examples
ChemInform Abstract: A New Indole Alkaloid from Cleome droserifolia.
Authors: Hussain Javid , Khan Hidayatullah , Ali Liaqat , Latif Khan Abdul , Ur Rehman Najeeb , Jahangir Sajid , Al‐Harrasi Ahmed
Published: October 2015

The title compound (I) appears to be a potent urease inhibitor.
ChemInform Abstract: Chemical Constituents of Anisodus luridus Roots and Their Antimicrobial Screening.
Authors: Verma Mradul , Lal Das Lalit Kumar , Gangwar Mayank , Sahai Mahendra , Nath Gopal , Singh Tryambak Deo
Published: October 2015

First time, potentially antimicrobial alkaloids β‐sitosterol, esculetin, β‐sitosterol‐β‐D‐glucoside, apohyoscyamine, and hyoscyamine are isolated from the methanolic extract of roots of Anisodus luridus.
ChemInform Abstract: Three New Coumarins from Saposhnikovia divaricata and Their Porcine Epidemic Diarrhea Virus (PEDV) Inhibitory Activity.
Authors: Yang Jun‐Li , Dhodary Basanta , Quy Ha Thi Kim , Kim Jinwoong , Kim Eunhee , Oh Won Keun
Published: October 2015

The new compounds (I)‐(III) show moderate inhibitory activity against PEDV in a dose‐dependent manner without any cytotoxicity.
ChemInform Abstract: Nickel Hexacyanoferrate as Suitable Alternative to Ag for Electrochemical Lithium Recovery.
Authors: Trocoli R. , Battistel A. , La Mantia F.
Published: October 2015

KNiFe(CN)6 with the Prussian blue structure precipitates from aqueous solutions of Ni(NO3)2 and K3Fe(CN)6 (sonication, 70 °C, 30 min).
ChemInform Abstract: Synthesis and Biological Activity of (γ‐Arylpyridino)‐dibenzoaza‐14‐crown‐4 Ethers.
Authors: Le Tuan Anh , Truong Hieu Hong , Thi Thanh Phoung Nguyen , Thi Nhung Dao , To Hai Tung , Thi Ha Pham , Soldatenkov Anatoly T.
Published: October 2015

Title compounds (III) are easily synthesized in one step.
ChemInform Abstract: Chemical Vapor Deposition of Monolayer Rhenium Disulfide (ReS2).
Authors: Tiwary Chandra Sekhar , et al.
Published: October 2015

Monolayer and multilayer ReS2 thin films are obtained by low‐temperature CVD (450 °C, 20 min) of NH4ReO4 and S on a Si/SiO2 (285 nm) wafer using Ar as carrier gas for S.
ChemInform Abstract: Progress in High‐Entropy Alloys
Authors: Gao Michael C.
Published: October 2015

Review: 9 refs.
ChemInform Abstract: Adsorption of NO and CO and Specific Features of Their Interaction on the Pt(100) Surface
Authors: Smirnov M. Yu.
Published: October 2015

Review: 127 refs.
ChemInform Abstract: Hybrid Organic—Inorganic Perovskites (HOIPs): Opportunities and Challenges
Authors: Kahn Antoine , et al.
Published: October 2015

Review: 91 refs.
ChemInform Abstract: Aromaticity Switching in Porphyrinoids
Authors: Pawlicki Milosz , Latos‐Grazynski Lechoslaw
Published: October 2015

Review: 95 refs.
ChemInform Abstract: Transition Metal‐Catalyzed C—H Bond Functionalizations by the Use of Diverse Directing Groups
Authors: Chen Zhengkai , Wang Binjie , Zhang Jitan , Yu Wenlong , Liu Zhanxiang , Zhang Yuhong
Published: October 2015

Review: [641 refs.
ChemInform Abstract: Stereoselective Electrophilic Cyclization
Authors: Sakakura Akira , Ishihara Kazuaki
Published: October 2015

Review: [rational design of monofunctionalized chiral Lewis base catalysts for enantioselective iodo‐ and protocyclizations as well as nucleophilic phosphite‐urea cooperative catalysts for the stereoselective promotion of electrophilic bromocyclizations; 31 refs.
ChemInform Abstract: Recent Advances in the Base‐Induced Sommelet—Hauser Rearrangement of Amino Acid Derived Ammonium Ylides
Authors: Tayama Eiji
Published: October 2015

Review: [26 refs.
ChemInform Abstract: Synthesis of Lobeline, Lobelane and Their Analogues. A Review
Authors: Zheng Guangrong , Crooks Peter A.
Published: October 2015

Review: 53 refs.
ChemInform Abstract: Ir‐Catalyzed Enantioselective Group Transfer Reactions
Authors: Schafer Andrew G. , Blakey Simon B.
Published: October 2015

Review: 50 refs.
ChemInform Abstract: Porous Polymer Catalysts with Hierarchical Structures
Authors: Sun Qi , Dai Zhifeng , Meng Xiangju , Xiao Feng‐Shou
Published: October 2015

Review: design, syntheses, and catalytic properties; 50 refs.
ChemInform Abstract: Hafnium Trifluoromethanesulfonate [Hf(OTf)4] as a Unique Lewis Acid in Organic Synthesis
Authors: Ishitani Haruro , Suzuki Hirotsugu , Saito Yuki , Yamashita Yasuhiro , Kobayashi Shu
Published: October 2015

Review: [62 refs.
ChemInform Abstract: Palladium‐Catalyzed Asymmetric Conjugate Addition of Arylboronic Acids to α,β‐Unsaturated Cyclic Electrophiles
Authors: Shockley Samantha E. , Holder Jeffrey C. , Stoltz Brian M.
Published: October 2015

Review: [32 refs.
ChemInform Abstract: Phytochemical Constituents and Biological Activities of Plants from the Genus dryopteris
Authors: Han Xue , Li Zheng , Li Chen‐Yang , Jia Wei‐Na , Wang Hong‐Tao , Wang Chun‐Hua
Published: October 2015

Review: 102 refs.
ChemInform Abstract: Towards Efficient Chemical Synthesis via Engineering Enzyme Catalysis in Biomimetic Nanoreactors
Authors: Liu Jia , Yang Qihua , Li Can
Published: October 2015

Review: [86 refs.
ChemInform Abstract: Advanced Developments in Cyclic Polymers: Synthesis, Applications, and Perspectives
Authors: Zhu Yinghuai , Hosmane Narayan S.
Published: October 2015

Review: 106 refs.
ChemInform Abstract: Anion‐π Interactions with Fluoroarenes
Authors: Giese Michael , Albrecht Markus , Rissanen Kari
Published: October 2015

Review: 166 refs.
ChemInform Abstract: The “Speedy” Synthesis of Atom‐Specific 15N Imino/Amido‐Labeled RNA
Authors: Neuner Sandro , Santner Tobias , Kreutz Christoph , Micura Ronald
Published: October 2015

Review: 82 refs.
ChemInform Abstract: Recent Advances in Biocatalytic Promiscuity: Hydrolase‐Catalyzed Reactions for Nonconventional Transformations
Authors: Lopez‐Iglesias Maria , Gotor‐Fernandez Vicente
Published: October 2015

Review: [102 refs.
ChemInform Abstract: Trimethylenemethane Diyl Mediated Tandem Cycloaddition Reactions: Mechanism Based Design of Synthetic Strategies
Authors: Lee Hee‐Yoon
Published: October 2015

Review: 71 refs.
ChemInform Abstract: Computational Studies of Synthetically Relevant Homogeneous Organometallic Catalysis Involving Ni, Pd, Ir, and Rh: An Overview of Commonly Employed DFT Methods and Mechanistic Insights
Authors: Sperger Theresa , Sanhueza Italo A. , Kalvet Indrek , Schoenebeck Franziska
Published: October 2015

Review: 590 refs.
ChemInform Abstract: Advancements in Wastewater Characterization Through NMR Spectroscopy: Review
Authors: Alves Filho Elenilson G. , Alexandre e Silva Lorena M. , Ferreira Antonio G.
Published: October 2015

Review: 131 refs.
ChemInform Abstract: Design Strategies of Fluorescent Probes for Selective Detection Among Biothiols
Authors: Niu Li‐Ya , Chen Yu‐Zhe , Zheng Hai‐Rong , Wu Li‐Zhu , Tung Chen‐Ho , Yang Qing‐Zheng
Published: October 2015

Review: 98 refs.
ChemInform Abstract: In situ EPR Spectroscopy in Heterogeneous Catalysis: Stepchild or Ray of Hope
Authors: Brueckner Angelika
Published: October 2015

Review: 61 refs.
Heteromerous Bistricyclic Aromatic Enes: Dynamic Stereochemistry of Xanthylidene‐Anthrones
Authors: Suissa M. Rachel , Cohen Shmuel , Pogodin Sergey , Agranat Israel
Published: October 2015

The heteromerous bistricyclic aromatic ene (BAE) 2,2'‐dimethyl‐10‐(9H‐xanthylidene)‐9(10H)‐anthrone (DMXA) was synthesized by a condensation of 10,10‐dichloro‐2‐methylxanthene with 2‐methylanthrone. X‐ray crystallography of (E)‐DMXA and xanthylidene‐anthrone (XA) indicated that the molecules adopt anti‐folded conformations with folding dihedral angles of 44°/44° and 39°/41°, respectively. The crystal structure of anti‐folded (E)‐DMXA does not indicate any xanthenylium–anthracenolate push–pull effect. E,Z‐diastereomerization of DMXA was studied by 1H‐NMR coalescence‐temperature measurements at different magnetic field strengths and by kinetic equilibration experiments. Free energy of activation for this process was 81.5 (±1.3) kJ/mol. B3LYP/6‐311+G(d,p) calculations showed that anti‐folded conformers of XA, (E)‐DMXA, bianthrone (AA), and dixanthylene (XX) were global minima. The twisted conformers of XA, AA, and XX were local minima (ΔG298 = 16, 18, and 24 kJ/mol) with a substantial dipolar xanthenylium–anthracenolate dipolar contribution for XA. Chirality 27:919–928, 2015. © 2015 Wiley Periodicals, Inc.
Lehrstück über Geschichte
Authors: Cornils Boy
Published: October 2015

Wie schon viele Unternehmen der Chemischen Industrie, zahlreiche Organisationen und selbst das Auswärtige Amt, so hat auch die Gesellschaft Deutscher Chemiker (GDCh) die Geschichte ihrer Vorgängervereine im Dritten Reich als VDCh (Verein Deutscher Chemiker) und DChG (Deutsche Chemische Gesellschaft, beides Gesellschaften, die vorzugsweise Industrie‐ bzw. Hochschulchemiker als Mitglieder umfaßten), Revue passieren lassen und mit dem vorliegenden Buch von H. Maier eine sehr eingehende und bedrückende Schilderung vorgelegt. Auf 741 Seiten (und einem Gewicht von 1,6 kg) wird unter dem Obertiel “Chemiker im Dritten Reich” mit dem Untertitel “Die Deutsche Chemische Gesellschaft und der Verein Deutscher Chemiker im NS‐Herrschaftsapparat” die Herkunft, das Verhalten und das Schicksal der beiden Gesellschaften der deutschen Chemiker geschildert.
Koffein gegen Stress
Authors: Fischer‐Henningsen Doris
Published: October 2015

Chronischer Stress kann krank machen. Koffein kann über eine Blockade des Adenosinrezeptors A2A Stresssymptome offenbar lindern oder ihnen sogar vorbeugen. Das hat ein internationales Forscherteam unter Federführung der portugiesischen Universität Coimbra kürzlich publiziert [1].
Efficient Light‐Driven Water Oxidation Catalysis by Dinuclear Ruthenium Complexes
Authors: Berardi Serena , Francàs Laia , Neudeck Sven , Maji Somnath , Benet‐Buchholz Jordi , Meyer Franc , Llobet Antoni
Published: October 2015

Mastering the light‐induced four‐electron oxidation of water to molecular oxygen is a key step towards the achievement of overall water splitting to produce alternative solar fuels. In this work, we report two rugged molecular pyrazolate‐based diruthenium complexes that efficiently catalyze visible‐light‐driven water oxidation. These complexes were fully characterized both in the solid state (by X‐ray diffraction analysis) and in solution (spectroscopically and electrochemically). Benchmark performances for homogeneous oxygen production have been obtained for both catalysts in the presence of a photosensitizer and a sacrificial electron acceptor at pH 7, and a turnover frequency of up to 11.1 s−1 and a turnover number of 5300 were obtained after three successive catalytic runs. Under the same experimental conditions with the same setup, the pyrazolate‐based diruthenium complexes outperform other well‐known water oxidation catalysts owing to both electrochemical and mechanistic aspects.
Comprehensive interactome of Otx2 in the adult mouse neural retina
Authors: Fant Bruno , Samuel Alexander , Audebert Stéphane , Couzon Agnès , El Nagar Salsabiel , Billon Nathalie , Lamonerie Thomas
Published: October 2015

The Otx2 homeodomain transcription factor exerts multiple functions in specific developmental contexts, probably through the regulation of different sets of genes. Protein partners of Otx2 have been shown to modulate its activity. Therefore, the Otx2 interactome may play a key role in selecting a precise target‐gene repertoire, hence determining its function in a specific tissue. To address the nature of Otx2 interactome, we generated a new recombinant Otx2CTAP‐tag mouse line, designed for protein complexes purification. We validated this mouse line by establishing the Otx2 interactome in the adult neural retina. In this tissue, Otx2 is thought to have overlapping function with its paralog Crx. Our analysis revealed that, in contrary to Crx, Otx2 did not develop interactions with proteins that are known to regulate phototransduction genes but showed specific partnership with factors associated with retinal development. The relationship between Otx2 and Crx in the neural retina should therefore be considered as complementarity rather than redundancy. Furthermore, study of the Otx2 interactome revealed strong associations with RNA processing and translation machineries, suggesting unexpected roles for Otx2 in the regulation of selected target genes all along the transcription/translation pathway. The Otx2CTAP‐tag line, therefore, appears suitable for a systematic approach to Otx2 protein–protein interactions. genesis 53:685–694, 2015. © 2015 Wiley Periodicals, Inc.
Globotriaosylceramide inhibits iNKT‐cell activation in a CD1d‐dependent manner
Authors: Pereira Catia S. , Sa‐Miranda Clara , De Libero Gennaro , Mori Lucia , Macedo Maria Fatima
Published: October 2015

Globotriaosylceramide (Gb3) is a glycosphingolipid present in cellular membranes that progressively accumulates in Fabry disease. Invariant Natural Killer T (iNKT) cells are a population of lipid‐specific T cells that are phenotypically and functionally altered in Fabry disease. The mechanisms responsible for the iNKT‐cell alterations in Fabry disease are not well understood. Here, we analyzed the effect of Gb3 on CD1d‐mediated iNKT‐cell activation in vitro using human cells and in vivo in the mouse model. We found that Gb3 competes with endogenous and exogenous antigens for CD1d binding, thereby reducing the activation of iNKT cells. This effect was exerted by a reduction in the amount of stimulatory CD1d:α–GalCer complexes in the presence of Gb3 as demonstrated by using an mAb specific for the complex. We also found that administration of Gb3 delivered to the same APC as α‐GalCer, induces reduced iNKT‐cell activation in vivo. This work highlights the complexity of iNKT‐cell activation and the importance of nonantigenic glycosphingolipids in the modulation of this process.
IL‐2 and IL‐15 regulate CD8+ memory T‐cell differentiation but are dispensable for protective recall responses
Authors: Mathieu Cédric , Beltra Jean‐Christophe , Charpentier Tania , Bourbonnais Sara , Di Santo James P. , Lamarre Alain , Decaluwe Hélène
Published: October 2015

The ability to mount effective secondary responses is a cardinal feature of memory CD8+ T cells. An understanding of the factors that regulate the generation and recall capacities of memory T cells remains to be ascertained. Several cues indicate that two highly related cytokines, IL‐2 and IL‐15, share redundant functions in this process. To establish their combined roles in memory CD8+ T‐cell development, maintenance, and secondary responses, we compared the outcome of adoptively transferred IL2Rβ+/− or IL2Rβ−/− CD8+ T cells after an acute viral infection in mice. Our results demonstrate that both IL‐2 and IL‐15 signals condition the differentiation of primary and secondary short‐lived effector cells by altering the transcriptional network governing lineage choices. These two cytokines also regulate the homeostasis of the memory T‐cell pool, with effector memory CD8+ T cells being the most sensitive to these two interleukins. Noticeably, the inability to respond to both cytokines limits the proliferation and survival of primary and secondary effectors cells, whereas it does not preclude potent cytotoxic functions and viral control either initially or upon rechallenge. Globally, these results indicate that lack of IL‐2 and IL‐15 signaling modulates the CD8+ T‐cell differentiation program but does not impede adequate effector functions.
Synthesis and Characterization of Chloro‐ and Alkyliron Complexes with N‐Donor Ligands and Their Reactivity towards CO2
Authors: Roth Cristina E. , Dibenedetto Angela , Aresta Michele
Published: October 2015

New iron(II) compounds with N‐donor ligands [2,2′‐bipyridine (bpy) and 2‐(2‐pyridyl)ethylamine (pyea)] were synthesized, and their reactivity with carbon dioxide was investigated. The reactions of Fe(bpy)(pyea)Cl2 (1) with CO2 (0.9 MPa) afforded the carbamato derivative Fe(bpy)(pyea‐CO2)Cl2 (2), which reacted with CH3Li to afford the monomethyl carbamato complex Fe(bpy)(pyea‐CO2)ClCH3 (3), an example of a carbamato species that is stable over a carboxylato moiety. Fe[(bpy)(pyea)](CH3)2 (4), obtained by reaction of 1 with CH3Li, was treated with CO2 (0.3–0.5 MPa) to afford the dicarboxylato species Fe[(bpy)(pyea)](O2CCH3)2 (5), which provides evidence of normal double insertion of CO2 into the Fe–C bond. The reaction of 5 with HCl afforded 1 and CH3–CO2H, which confirmed the mode of bonding of the –O2CCH3 moiety to the Fe center. To verify the preference of insertion of CO2 into the Fe–C or the Fe–N bond, 1 was treated with MeLi (1 equiv.), and Fe(bpy)(pyea)Cl(CH3) (6) was isolated as a low‐melting solid. The latter was treated with CO2 (0.5 MPa), and the product of insertion into the Fe–CH3 bond was observed as the only carboxylate (7). The faster insertion into the Fe–CH3 bond is explained by the fact that the N donor is quaternarized upon interaction with the metal center and has no free electrons available to interact with the C acceptor of the cumulene molecule; thus, more‐forcing conditions (0.9 MPa) are required for the insertion to occur.
Solid‐Supported Iodonium Salts for Fluorinations
Authors: Edwards Richard , de Vries Wilke , Westwell Andrew D. , Daniels Stephen , Wirth Thomas
Published: October 2015

Solid‐supported iodonium salt precursors have been prepared and used for the production of fluoroarenes. The importance of the resin functionality for the attachment of the iodonium salt moieties has been demonstrated. Furthermore, the production of new iodonium salt precursors for fluorination has been achieved by an alternative and improved method with respect to those previously described. The successful radiofluorination of a simple solid‐supported precursor with no‐carrier‐added (n.c.a.) [18F]fluoride shows the suitability of the method for the production of useful PET synthons.
Brain activity modifications following spinal cord stimulation for chronic neuropathic pain: A systematic review
Authors: Bentley L. D. , Duarte R. V. , Furlong P. L. , Ashford R. L. , Raphael J. H.
Published: October 2015

Background and objective

Spinal cord stimulation (SCS) is believed to exert supraspinal effects; however, these mechanisms are still far from fully elucidated. This systematic review aims to assess existing neurophysiological and functional neuroimaging literature to reveal current knowledge regarding the effects of SCS for chronic neuropathic pain on brain activity, to identify gaps in knowledge, and to suggest directions for future research.

Databases and data treatment

Electronic databases and hand‐search of reference lists were employed to identify publications investigating brain activity associated with SCS in patients with chronic neuropathic pain, using neurophysiological and functional neuroimaging techniques (fMRI, PET, MEG, EEG). Studies investigating patients with SCS for chronic neuropathic pain and studying brain activity related to SCS were included. Demographic data (age, gender), study factors (imaging modality, patient diagnoses, pain area, duration of SCS at recording, stimulus used) and brain areas activated were extracted from the included studies.

Results

Twenty‐four studies were included. Thirteen studies used neuroelectrical imaging techniques, eight studies used haemodynamic imaging techniques, two studies employed both neuroelectrical and haemodynamic techniques separately, and one study investigated cerebral neurobiology.

Conclusions

The limited available evidence regarding supraspinal mechanisms of SCS does not allow us to develop any conclusive theories. However, the studies included appear to show an inhibitory effect of SCS on somatosensory evoked potentials, as well as identifying the thalamus and anterior cingulate cortex as potential mediators of the pain experience. The lack of substantial evidence in this area highlights the need for large‐scale controlled studies of this kind.
Recent applications of CE‐ and HPLC‐MS in the analysis of human fluids
Authors: Iadarola Paolo , Fumagalli Marco , Bardoni Anna Maria , Salvini Roberta , Viglio Simona
Published: October 2015

The present review intends to cover the literature on the use of CE‐/LC‐MS for the analysis of human fluids, from 2010 until present. It has been planned to provide an overview of the most recent practical applications of these techniques to less extensively used human body fluids, including, bronchoalveolar lavage fluid, synovial fluid, nipple aspirate, tear fluid, breast fluid, amniotic fluid, and cerumen. Potential pitfalls related to fluid collection and sample preparation, with particular attention to sample clean‐up procedures, and methods of analysis, from the research laboratory to a clinical setting will also be addressed. While being apparent that proteomics/metabolomics represent the most prominent approaches for global identification/quantification of putative biomarkers for a variety of human diseases, evidence is also provided of the suitability of these sophisticated techniques for the detection of heterogeneous components carried by these fluids.
Telomere measurement in individuals occupationally exposed to pesticide mixtures in tobacco fields
Authors: Kahl Vívian Francília Silva , Simon Daniel , Salvador Mirian , Branco Cátia dos Santos , Dias Johnny Ferraz , da Silva Fernanda Rabaioli , de Souza Claudia Telles , da Silva Juliana
Published: October 2015

Occupational exposure to pesticides in tobacco fields causes genetic damage in farmers. The aim of this study was to analyze tobacco farmers chronically exposed to low doses of pesticides and nicotine (present in the tobacco leaves) in relation to absolute telomere length (aTL), and explore the influence of lifestyle characteristics, oxidative stress, and inorganic element levels. DNA was isolated from peripheral blood samples from agricultural workers and non‐exposed individuals, and aTL was measured by quantitative real time polymerase chain reaction (qPCR) analysis. Oxidative stress (thiobarbituric acid reactive substances [TBARS], which measures oxidative damage to lipids; and toxic equivalent antioxidant capacity [TEAC], which measures total equivalent antioxidant capacity) was evaluated in serum, and inorganic element content was analyzed in whole blood through particle‐induced X‐ray emission technique. It was found that exposure to pesticides and tobacco smoking had significant effects on aTL. Individuals occupationally exposed to complex mixtures of pesticides in tobacco fields and individuals who smoked had decreased aTL compared with the non‐exposed group. TBARS and TEAC were significantly elevated in the exposed group. There were no significant differences in inorganic elements. There was no evidence of an influence of age, gender, consumption of alcoholic beverages, or intake of fruits and vegetables on aTL within the groups. In addition, years of work in the tobacco field in the exposed group did not influence any of the variables analyzed. Although further studies were needed, these results suggested differences in telomere maintenance in tobacco farmers compared with the control group, indicating that telomere length may be a good biomarker of occupational exposure. Environ. Mol. Mutagen. 57:74–84, 2016. © 2015 Wiley Periodicals, Inc.
House Prices and Current Account Imbalances in OECD Countries
Authors: Arestis Philip , Gonzalez‐Martinez Ana Rosa
Published: October 2015

This contribution attempts to provide theoretical propositions and empirical evidence on the ‘obscure’ relationship between current account imbalances and house prices. We propose a theoretical framework, which studies the interaction between house prices and current account imbalances and also pays special attention to the role played by fiscal and monetary policies. In a second stage of this contribution, our theoretical framework is estimated empirically by using data from 17 OECD economies, which spans the period 1970–2013. In doing so, the least squares technique with breakpoints is employed. Copyright © 2015 John Wiley & Sons, Ltd.
Exploring the Value of the Substance Abuse Subtle Screening Inventory–3 for Predicting Attrition and Recidivism Among Perpetrators of Intimate Partner Violence
Authors: VanMeter Carrie , Laux John M. , Piazza Nick , Ritchie Martin , Tucker‐Gail Kasey
Published: October 2015

This study explored the potential value of the Substance Abuse Subtle Screening Inventory–3 (SASSI‐3; F. G. Miller & Lazowski, ) as a means of predicting program attrition and recidivism among perpetrators of intimate partner violence, concluding that the SASSI‐3 is not an adequate predictor.
Development of chitosan/poly‐γ‐glutamic acid/pluronic/curcumin nanoparticles in chitosan dressings for wound regeneration
Authors: Lin Yu‐Hsin , Lin Jui‐Hsiang , Hong Ya‐Shiuan
Published: October 2015

The hydrophobic polyphenol curcumin has anti‐inflammatory, antimicrobial, and wound‐healing properties that warrant its pharmacological consideration. We report a curcumin nanoparticle with a tripolymeric composite that can be used as a delivery device for wound healing. The present composite nanoparticles were prepared with three biocompatible polymers of chitosan, poly‐γ‐glutamic acid, and pluronic using a simple ionic gelation technology. Pluronic was used to enhance the solubility of curcumin in chitosan/poly‐γ‐glutamic acid nanoparticles, leading to the incorporation of chitosan/poly‐γ‐glutamic acid/pluronic/curcumin nanoparticles into chitosan membranes, and reduced inflammation and bacterial infection during wound regeneration. Nanoparticles were of 193.1 ± 8.9 nm and had a zeta potential of 20.6 ± 2.4 mV. Moreover, in vitro analyses indicated controlled curcumin release in a simulated skin tissue model. Subsequent in vivo studies show that chitosan wound dressing containing chitosan/poly‐γ‐glutamic acid/pluronic/curcumin nanoparticles promoted neocollagen regeneration and tissue reconstruction. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 81–90, 2017.
Improving healthcare worker hand hygiene adherence before patient contact: A multimodal intervention of hand hygiene practice in Three Japanese tertiary care centers
Authors: Sakihama Tomoko , Honda Hitoshi , Saint Sanjay , Fowler Karen E. , Kamiya Toru , Sato Yumiko , Iuchi Ritsuko , Tokuda Yasuharu
Published: October 2015

BACKGROUND

Though hand hygiene is an important method of preventing healthcare‐associated infection, we found suboptimal hand hygiene adherence among healthcare workers in 4 diverse Japanese hospitals (adherence rates of 11%–25%).

OBJECTIVE

Our goal was to assess multimodal hand hygiene intervention coupled with a contest to improve hand hygiene adherence.

SETTING

A total of 3 to 4 inpatient wards in 3 Japanese hospitals.

DESIGN

Pre‐post intervention study.

INTERVENTION

The intervention was a multimodal hand hygiene intervention recommended by the World Health Organization that was tailored to each facility. The hospital with the highest adherence after the intervention was given $5000 US dollars and a trophy, provided by an American coinvestigator unaffiliated with any of the Japanese hospitals.

MEASUREMENT

We tracked hand hygiene adherence rates before patient contact for each unit and hospital and compared these to pre‐intervention adherence rates.

RESULTS

We observed 2982 postintervention provider‐patient encounters in 10 units across 3 hospitals. Hand hygiene adherence rates were improved overall after the intervention (18% pre‐ to 33% postintervention; P < 0.001), but postintervention adherence rates varied considerably: hospital A + 29%, B + 5%, C + 8%. Hospital A won the contest with 40% adherence after the intervention.

CONCLUSIONS

Using a novel contest coupled with a multimodal intervention successfully improved hand hygiene rates among Japanese healthcare workers. Given the overall low rates, however, further improvement is necessary. Journal of Hospital Medicine 2016;11:199–205. © 2015 Society of Hospital Medicine
Reliability and Validity of the Chinese Version of the Solution‐Focused Inventory in College Students
Authors: Yang Hongfei , Hai Tang
Published: October 2015

The psychometrics of the Chinese Solution‐Focused Inventory (CSFI) was studied in Chinese college students. Confirmatory factor analysis confirmed the 3‐factor structure. All subscales showed good reliability and convergent and incremental validity. Results of hierarchical regression analyses indicated that the 3 subscales accounted for additional variance in psychological adjustment above and beyond resilience. These findings indicated that the CSFI is reliable and valid. Implications, limitations, and future study orientations are discussed.

Se estudió la psicometría del Inventario Chino Centrado en Soluciones (CSFI, por sus siglas en inglés) en estudiantes universitarios chinos. El análisis de confirmación de factores confirmó la estructura de 3 factores. Todas las subescalas mostraron buena confiabilidad, además de validez convergente y progresiva. Los resultados de los análisis de regresión jerárquica indicaron que las 3 subescalas representaron la varianza adicional en el ajuste psicológico más allá de la resiliencia. Estos hallazgos indicaron que el CSFI es válido y confiable. Se discuten las implicaciones, limitaciones y orientaciones para estudios futuros.
A Phenomenological Inquiry of Clients' Experiences of Receiving a Humanistically Oriented Therapeutic Letter From Their Counselor Between Counseling Sessions
Authors: LAMPRECHT LOGAN M.
Published: October 2015

This qualitative study investigated the lived experiences of 6 female clients who received a humanistically oriented letter from their counselor between counseling appointments. Five core themes resulted concerning shared perspectives of the letter's impact on the recipients. A brief discussion, including limitations and recommendations, is provided.
Negative bias illumination stress assessment of indium gallium zinc oxide thin‐film transistors
Authors: Hoshino Ken , Wager John
Published: October 2015

Electrical performance stability of indium gallium zinc oxide (IGZO) thin‐film transistors (TFTs) is evaluated under negative bias illumination stress (NBIS). A bottom‐gate IGZO TFT whose top surface is passivated with zinc tin silicon oxide (ZTSO) exhibits a dramatic improvement in NBIS stability compared with that of an unpassivated, bottom‐gate IGZO TFT. Oxygen chemisorption/desorption at the channel layer top surface is proposed to explain why an unpassivated TFT exhibits significantly more NBIS than a passivated TFT.
Reliability of measures of quadriceps muscle function using magnetic stimulation
Authors: Tofari Paul J. , Opar David A. , Kemp Justin G. , Billaut Francois , Cormack Stuart
Published: October 2015

Introduction: Magnetic stimulation can be used to assess muscle function by calculating voluntary activation using an interpolated twitch during maximal voluntary contractions (MVCs) and control twitches to potentiated muscle. In this study we assessed the reliability of torque, electromyography (EMG), and voluntary activation variables. Methods: Fifteen men completed 5 testing sessions (2 familiarization and 3 reliability trials) to assess quadriceps femoris muscle function. Intra‐ and interday reliability levels of torque and EMG variables were estimated using typical error ± 90% confidence limits, expressed as percentage [coefficient of variation (CV)] and intraclass correlation coefficient. The smallest worthwhile change was calculated as 0.2 × between‐participant standard deviation. Results: Intra‐ and interday torque variables for MVC were reliable (CV < 4%, ICC 0.98, and CV < 5%, ICC 0.99, respectively). EMG variables were less reliable than torque variables, with CVs ranging from 7% to 18%. Conclusion: Magnetic stimulation of the femoral nerve is a reliable method for assessing muscle function. Muscle Nerve 53: 770–778, 2016
Peritumoral tissue compression is predictive of exudate flux in a rat model of cerebral tumor: an MRI study in an embedded tumor
Authors: Ewing James R. , Nagaraja Tavarekere N. , Aryal Madhava P. , Keenan Kelly A. , Elmghirbi Rasha , Bagher‐Ebadian Hassan , Panda Swayamprava , Lu Mei , Mikkelsen Tom , Cabral Glauber , Brown Stephen L.
Published: October 2015

MRI estimates of extracellular volume and tumor exudate flux in peritumoral tissue are demonstrated in an experimental model of cerebral tumor. Peritumoral extracellular volume predicted the tumor exudate flux.

Eighteen RNU athymic rats were inoculated intracerebrally with U251MG tumor cells and studied with dynamic contrast enhanced MRI (DCE‐MRI) approximately 18 days post implantation. Using a model selection paradigm and a novel application of Patlak and Logan plots to DCE‐MRI data, the distribution volume (i.e. tissue porosity) in the leaky rim of the tumor and that in the tissue external to the rim (the outer rim) were estimated, as was the tumor exudate flow from the inner rim of the tumor through the outer rim.

Distribution volume in the outer rim was approximately half that of the inner adjacent region (p < 1 × 10−4). The distribution volume of the outer ring was significantly correlated (R2 = 0.9) with tumor exudate flow from the inner rim. Thus, peritumoral extracellular volume predicted the rate of tumor exudate flux. One explanation for these data is that perfusion, i.e. the delivery of blood to the tumor, was regulated by the compression of the mostly normal tissue of the tumor rim, and that the tumor exudate flow was limited by tumor perfusion. Copyright © 2015 John Wiley & Sons, Ltd.
A proteomics approach to identifying key protein targets involved in VEGF inhibitor mediated attenuation of bleomycin‐induced pulmonary fibrosis
Authors: Kulkarni Yogesh M. , Dutta Sucharita , Iyer Anand Krishnan V. , Venkatadri Rajkumar , Kaushik Vivek , Ramesh Vani , Wright Clayton A. , Semmes Oliver John , Yakisich Juan S. , Azad Neelam
Published: October 2015

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with a life expectancy of less than 5 years post diagnosis for most patients. Poor molecular characterization of IPF has led to insufficient understanding of the pathogenesis of the disease, resulting in lack of effective therapies. In this study, we have integrated a label‐free LC‐MS based approach with systems biology to identify signaling pathways and regulatory nodes within protein interaction networks that govern phenotypic changes that may lead to IPF. Ingenuity Pathway Analysis of proteins modulated in response to bleomycin treatment identified PI3K/Akt and Wnt signaling as the most significant profibrotic pathways. Similar analysis of proteins modulated in response to vascular endothelial growth factor (VEGF) inhibitor (CBO‐P11) treatment identified natural killer cell signaling and PTEN signaling as the most significant antifibrotic pathways. Mechanistic/mammalian target of rapamycin (mTOR) and extracellular signal‐regulated kinase (ERK) were identified to be key mediators of pro‐ and antifibrotic response, where bleomycin (BLM) treatment resulted in increased expression and VEGF inhibitor treatment attenuated expression of mTOR and ERK. Using a BLM mouse model of pulmonary fibrosis and VEGF inhibitor CBO‐P11 as a therapeutic measure, we identified a comprehensive set of signaling pathways and proteins that contribute to the pathogenesis of pulmonary fibrosis that can be targeted for therapy against this fatal disease.
The role of illness perceptions in adherence to surveillance in patients with familial adenomatous polyposis (FAP)
Authors: Eriksson Lars E. , Fritzell Kaisa , Rixon Lorna , Björk Jan , Wettergren Lena
Published: October 2015

Objective

The aim of the study was to examine patients' beliefs about having familial adenomatous polyposis (FAP), a hereditary colorectal cancer syndrome, and how these beliefs are associated with adherence to endoscopic surveillance.

Methods

Adult patients diagnosed with FAP on the national Swedish polyposis register who had undergone prophylactic colorectal surgery (n 209, response rate 76%) completed the Illness Perception Questionnaire (IPQ). Logistic regression analysis was used to investigate the relationships between illness perceptions and adherence, when controlling for demographic and clinical factors.

Results

FAP was less distressing in men and those with fewer symptoms, reporting less serious consequences and more coherent understanding of FAP. Non‐adherence (14%) to surveillance was associated with being older, having undergone surgery less recently and no history of malignancy. Patients' beliefs about their FAP were able to explain unique variance in non‐adherence, in particular those who believed FAP was less distressing.

Conclusions

Patients who were non‐adherent to endoscopic surveillance had more positive perceptions about their FAP and, in particular, were less emotionally affected compared to those who adhered. As non‐adherence implies a greater risk of future malignancies, special efforts are required to effectively prevent cancer in all patients with FAP. Those who have lived with the condition for a long time, and are not troubled by gastrointestinal symptoms or worried about their FAP, may be in need of specific information and support. Further prospective research is required to examine emotional predictors and consequences of non‐adherence. Copyright © 2015 John Wiley & Sons, Ltd.