bluuebunny/crossref_metadata_2025 huggingface dataset:
The impact of modifier genes on cone-rod dystrophy heterogeneity: An explorative familial pilot study and a hypothesis on neurotransmission impairment
Authors: Donato Luigi , Alibrandi Simona , Scimone Concetta , Rinaldi Carmela , Dascola Angela , Calamuneri Alessandro , D’Angelo Rosalia , Sidoti Antonina
Published: December 2022

Cone-rod dystrophies (CORDs) are a heterogeneous group of inherited retinopathies (IRDs) with more than 30 already known disease-causing genes. Uncertain phenotypes and extended range of intra- and interfamilial heterogenicity make still difficult to determine a precise genotype-phenotype correlation. Here, we used a next-generation sequencing approach to study a Sicilian family with a suspected form of CORD. Affected family members underwent ophthalmological examinations and a proband, blind from 50 years, underwent whole genome and exome sequencing. Variant analysis was enriched by pathway analysis and relevant variants were, then, investigated in other family members and in 100 healthy controls from Messina. CORD diagnosis with an intricate pattern of symptoms was confirmed by ophthalmological examinations. A total of about 50,000 variants were identified in both proband’s genome and exome. All affected family members presented specific genotypes mainly determined by mutated GUCY2D gene, and different phenotypical traits, mainly related to focus and color perception. Thus, we looked for possible modifier genes. According to relationship with GUCY2D, predicted functional effects, eye localization, and ocular disease affinity, only 9 variants, carried by 6 genes (CACNG8, PAX2, RXRG, CCDC175, PDE4DIP and LTF), survived the filtering. These genes encode key proteins involved in cone development and survival, and retina neurotransmission. Among analyzed variants, CACNG8c.*6819A>T and the new CCDC175 c.76C>T showed extremely low frequency in the control group, suggesting a key role on disease phenotypes. Such discovery could enforce the role of modifier genes into CORD onset/progression, contributing to improve diagnostic test towards a better personalized medicine.
A Patient with Monoclonal Gammopathy of Undetermined Significance and Detected Philadelphia Chromosome
Authors: Tran Truc , Cai Jennifer , Ji Ping , Qing Xin
Published: December 2022

Background
Monoclonal gammopathy of undetermined significance (MGUS) and chronic myeloid leukemia (CML) are diseases of different lineages. The diagnosis of both MGUS and CML in the same patient is a rare occurrence and has not been reported in much literature.

Case Presentation
We describe a 56-year-old man with a history of rheumatoid arthritis incidentally found to have an increase in IgA paraprotein. With less than 10% monoclonal plasma cells on the bone marrow biopsy and absence of hypercalcemia, renal failure, anemia and bone lesions, MGUS was diagnosed. The conventional cytogenetics at the time showed the presence of the Philadelphia chromosome in 30% of metaphases. However, there was no morphologic evidence of CML in the peripheral blood or bone marrow. Patient received no treatment and lost follow-up until 3 years later when a routine CBC showed leukocytosis and thrombocytosis. CML, chronic phase was diagnosed following a bone marrow aspiration and biopsy with Philadelphia chromosome observed in 100% of metaphases. Patient was treated with imatinib and later switched to dasatinib and complete molecular remission was continued to be achieved.

Discussion and Conclusion
Here we report a case of pre-leukemic CML as an incidental finding during the diagnosis of MGUS. The possible underlying mechanisms of the association are discussed although the exact cause of the coexistence is unclear.
Cerebrovascular Infarction Presenting as Bilateral Internuclear Ophthalmoplegia in a 75 y/o Patient
Authors: J. Agustin Kim
Published: December 2022

Objective
To present a case of Bilateral Internuclear Ophthalmoplegia in a 75yo patient

Case Description
A 75 year old, Filipino, male, known hypertensive for 10 years, but not compliant to medications, presented with a sudden onset binocular horizontal, diplopia and bilateral exotropia associated with dizziness. No other symptoms like slurring of speech, body weakness, numbness were noted. Primary gaze exotropia, abduction nystagmus, gaze evoked vertical nystagmus were also noted. Imaging was done which revealed hypodense focus in the subcortical region of the right centrum semiovale extending to the right corona radiata, with unremarkable orbits, midbrain and pons findings.

WEBINO was still considered even without the presence of a pontine lesion in the imaging. The patient was advised patching and was asked to follow up after a month
INADEQUACY OF ENVIRONMENTAL CONDITIONS AND LEARNING CHARACTERISTICS AT THE UNIVERSITY: STRATEGIES FOR TEACHING MANAGEMENT
Authors: Sousa Thiago Ferreira de , Barros Gerleison Ribeiro , Brandão Alex Carneiro , Fonseca Sandra Celina Fernandes
Published: December 2022

O objetivo deste estudo foi caracterizar, como ferramenta para a gestão de ensino, a autoavaliação negativa das condições do ambiente e características de aprendizagem na universidade, por universitários, de acordo com a habilitação (licenciatura e bacharelado) entre três anos. Para tal foi utilizada a Escala Condições do Ambiente e Características de Aprendizagem na Universidade (CACAU) que integra o questionário Indicadores de Saúde e Qualidade de Vida em Acadêmicos (ISAQ-A). Houve a participação de 1.084, 1.085 e 1.041 universitários em três inquéritos realizados nos anos de 2010, 2012 e 2014, respectivamente. Os estudantes universitários dos cursos do bacharelado apresentaram um aumento linear das frequências relativas de autoavaliação negativa das condições de estrutura das salas de aula e foram mais propensos a avaliar o seu nível de conhecimento antes do ingresso no ensino superior em condição de inadequação. Conclui-se que a Escala CACAU representa uma importante estratégia para a gestão do ensino superior no Brasil.
DIETA E SONO NO IDOSO
Authors: Fonseca Sandra C. F. , Mourão-Carvalhal Maria Isabel , Mendes Márcia , Coelho Eduarda Maria Rocha Teles de Castro
Published: December 2022

A má qualidade e a redução do número de horas de sono, resultante do processo de envelhecimento, são queixa comum em indivíduos idosos. Neste contexto, com este trabalho pretendemos refletir sobre a importância que a alimentação tem na melhoria da qualidade e duração do sono em idosos. A pesquisa foi realizada tendo como bases de dados a PubMed, a B-on e a Scopus, empregando os seguintes descritores “diet”, “sleep”, “elderly”. Constatámos que existem poucos estudos que relacionam as duas variáveis, e os resultados indiciam a eficácia da alimentação como uma intervenção não farmacológica ao nível da melhoria da qualidade e duração do sono em idosos, contribuindo assim para uma melhor qualidade de vida e bem-estar. A educação/promoção de um estilo de vida saudável, com particular atenção na alimentação e nutrição, deverá ser contemplada ao longo do ciclo de vida e, particularmente, na formação dos profissionais com vista a promover a melhoria nos padrões de saúde e na qualidade de vida e do sono na terceira idade.
RETENTION FACTORS IN THE ADMINISTRATION COURSE: A STUDY AT THE VALE DO ACARAÚ STATE UNIVERSITY
Authors: Filho Francisco O. C. , Bezerra Sefisa Quixadá
Published: December 2022

Neste trabalho trabalharemos um tema transversal: a administração e a educação como uma política pública, que deve ser ofertada com qualidade pelo Estado a todos os brasileiros. O estudo foi desenvolvido desde 2019 a partir de um prévio levantamento de dados que foi apresentado na Iniciação Científica desta universidade e despertou a continuidade da pesquisa devido ao alto quantitativo de alunos retidos e evadidos no curso de Administração. Analisaremos a retenção como a condição que um aluno de um curso superior tem de manter-se além do período estipulado da integralização, a fim de concluí-lo. O presente estudo buscará identificar os motivos pelos os quais os alunos do curso de Administração da Universidade Estadual Vale do Acaraú (UVA) irão concluir seu curso em um tempo maior que cinco anos, período considerado normal pelo projeto pedagógico que o curso estabelece. O estudo teve pesquisa direta realizada através de aplicação de questionário pelo Google Forms com os alunos. Os dados indicam que questões relativas à estrutura curricular do curso, os casos de greve na instituição, a conciliação entre trabalho e estudos, são alguns dos fatores de retenção. Em contrapartida, houve indicativos que essa retenção poderia ser reduzida com acompanhamento para aqueles alunos que apresentam dificuldades em relação a formas e horários de disciplinas.
A INTERVENÇÃO DAS ONG NAS ZONAS RURAIS DA GUINÉ-BISSAU
Authors: Oliveira Patrícia , Rodrigues Maria José
Published: December 2022

O presente texto enquadra-se num trabalho mais amplo realizado no âmbito do mestrado em Educação Ambiental, no Instituto Politécnico de Bragança, cuja finalidade era descrever o trabalho da Educação Ambiental, desenvolvido nas comunidades rurais da Guiné-Bissau (GB) por Organizações Não Governamentais (ONG). Consideramos que na GB é imperativo o desenvolvimento da educação ambiental em todos os contextos, principalmente no âmbito não formal e informal, para promover mudanças de comportamento, atitudes e valores em relação à sociedade, ao ambiente, entre outros. Neste contexto, para este texto definimos como objetivo: conhecer as intervenções das ONG no âmbito ambiental nas comunidades rurais da GB. Relativamente à natureza da investigação trata-se de um estudo qualitativo, com características descritivas. Para recolha de dados recorreu-se à análise documental. Os resultados evidenciaram que as ONG realizam ações de EA nas comunidades. Estas ações promovem mudanças visíveis nas comunidades. A cultura local é sempre tida em conta na elaboração e execução de projetos, sendo fundamental reforçar o envolvimento e o comprometimento como forma de proporcionar a participação de todos e principalmente das mulheres e no seu empoderamento.
ART AND THE CREATIVE PROCESS IN EDUCATION FOR ENGINEERS: A STUDY FOCUSED ON UTFPR, BRAZIL
Authors: Auzani Adriana Santos , Silva Levi Leonido , Morgado Elsa Maria Gabriel , Pereira Antonino Manuel de Almeida
Published: December 2022

Esta pesquisa teve como objetivo estudar a função da arte na promoção da criatividade nos processos formativos dos acadêmicos de engenharia da Universidade Tecnológica Federal do Paraná (UTFPR), enquanto fator de inovação tecnológica. Desenvolvida no âmbito do paradigma construtivista, foi utlizado o método qualitativo, nomeadamente o estudo de caso.  A fonte de recolha de dados utlizada foi a entrevista semiestruturada, tendo os respetivos guiões sido desenvolvidos no âmbito da Teoria das Representações Sociais de Serge Moscovici (1978). O campo de estudo foi constituído por 10 estudantes e egressos, por 10 professores, coordenadores e diretores de Ensino e do Campus de Pato Branco, pelo Reitor da universidade e por 4 empresários. A técnica de tratamento de dados utlizada foi a análise de conteúdo.  De entre as principais conclusões, saliente-se que os entrevistados entendem que a arte pode contribuir para a melhoria da formação académica do estudante de engenharia uma vez que proporciona novos pontos de vista, promove a criatividade e a inovação. Defendem também que atividades como o teatro podem estimular a capacidade criativa em ambiente universitário dos engenheiros já que permite a promoção da comunicação e expressão, desenvolvimento de um profissional mais completo e favorece a capacidade de abstração. Por último, entendem que a arte e suas diversas expressões estéticas são importantes na formação acadêmica do engenheiro no que diz respeito à criação de projetos inovadores, uma vez que favorece a inspiração, a inovação e a integração em equipes.
PEMBAHARUAN SISTEM PRESIDENTIAL THRESHOLD DI INDONESIA BERDASARKAN KONSEP PRISMATIKA HUKUM
Authors: Arifudin Arifudin , Zoelva Hamdan
Published: December 2022

Presidential threshold merupakan persyaratan bagi partai atau gabungan partai politik yang akan mengusung calon Presiden dan Wakil Presiden dalam pemilu. Namun, Presidential threshold perlu dilakukan pembaharuan melalui konsep prismatika hukum agar memiliki dampak pada kualitas demokrasi. Tujuan dari penelitian ini untuk mengetahui dinamika pengaturan presidential threshold; kelemahan pengaturan presidential threshold; dan pembaharuan sistem presidential threshold di Indonesia berdasarkan konsep prismatika hukum. Hasil pembahasan dengan metode penelitian yuridis normatif ini adalah dinamika presidential threshold terdapat pada besaran prosentase perolehan kursi di DPR atau suara sah secara nasional. Kelemahan presidential threshold yaitu terbukanya peluang otoritaririanisme dan praktik oligarki dalam berdemokrasi. Sedangkan pembaharuan sistem presidential threshold melalui konsep prismatika hukum dapat dikonstruksikan dengan memadukan unsur kuantitas dan kualitas dalam pencalonan presiden dan wakil presiden.
METAVERSE AND ITS IMPLICATION IN LAW AND BUSINESS
Authors: Johan Suwinto
Published: December 2022

We hear that the future world is the world of the Metaverse. Metaverse is a virtual space created by digital versions of various aspects of life. This study aims to examine the function of law in the metaverse world. This study uses a normative juridical method. This study concludes that the metaverse world still requires the implementation of different laws. The current laws and regulations need to make implementation adjustments in the metaverse world. The change from the real world to the virtual world is like how communication in the real world becomes digital communication that we are experiencing. Adjustments to human behavior must be accompanied by adjustments to the governing regulations. State boundaries become fictitious, and applicable laws do not recognize state and government boundaries.
Daftar Isi Jurnal Hukum Progresif, Vol. 10, No. 2, Oktober 2022
Authors: Progresif Jurnal Hukum
Published: December 2022

Daftar Isi Jurnal Hukum Progresif, Vol. 10, No. 2, Oktober 2022
Súdne spory v oblasti transferového oceňovania na Slovensku – relevancia OECD smernice o transferovom oceňovaní
Authors: Kačaljak Matej
Published: December 2022

The legal relevance of the OECD TP Guidelines in Slovakia has already been addressed in the previous literature with the seemingly surprising conclusion that despite its general acceptance in practice, it is not a source of law and the principle of iura novit curia does not apply to it. The object of this article is to supplement the existing state of knowledge by identifying the reasons that led to the procedural tactics of taxpayers who challenged the OECD TP Guidelines and its legal relevance en bloc in Slovakia and formulating considerations on how the OECD TP Guidelines should be approached in both application and judicial practice. Disputes between taxpayers and tax administrators to date indicate that there are fundamental defects in the approach to the OECD TP Guidelines, where its individual sentences are referred to as legal norms, which inevitably leads to disputes over the interpretation of this non-binding (soft law) document. Thus, a prerequisite for the OECD TP Guidelines to be enforced is their consistent application by both taxpayers and tax administrators. However, despite the above, it cannot be reasonably expected the OECD TP Guidelines would be relevant in the event of litigation. None of the statements contained therein are capable of overcoming the factual situation established by the evidence gathered (i.e., establishing a legal fiction) or of completing the factual situation where it is not apparent from the evidence (i.e., establishing a legal presumption). The key in a dispute before the court will therefore always be a proper finding of the facts and precise reasoning in any tax assessment decision. This understandably raises the demands on the quality of the tax administrator’s reasons for its decisions.
Enhancing bilingual resources in third language acquisition: towards pedagogical translanguaging
Authors: Cenoz Jasone , Gorter Durk
Published: December 2022

Third language acquisition in educational contexts is nowadays expanding in monolingual and multilingual contexts. One reason is the mobility of the population that results in an increasing number of home languages that are different from the school languages. Another reason is the spread of the teaching of English as a third language in multilingual school contexts where two other languages are also taught. Third language acquisition is a complex phenomenon that shares many characteristics with second language acquisition but also has some specific differences related to the effect of bilingualism on third language acquisition, multilingual learners’ repertoires and the specific role of metalinguistic awareness in language learning. The aim of this paper is threefold: 1) to look at the potential advantages of bilingualism on L3 considering the great diversity of situations in which an L3 is learned in school contexts; 2) to look at the similarities and differences between second and third language acquisition and 3) to discuss how pedagogical translanguaging can enhance bilingual resources so that L3 learners can develop an optimal use of their resources.
Two case reports of skin vasculitis following the COVID-19 immunization
Authors: Chomičienė Anželika , Černiauskas Kęstutis , Linauskienė Kotryna , Meškauskas Raimundas , Malinauskienė Laura
Published: December 2022

The coronavirus 2019 (COVID-19) disease is now responsible for one of the most challenging and concerning pandemics. Since December 2020, the world has had access to COVID-19 prophylaxis; thus, we encounter adverse events from vaccination more often due to the vast vaccination range. We present two case reports of difficult-to-treat skin vasculitis due to COVID-19 vaccination that were successfully treated in a tertiary-level university hospital. When encountering systemic treatment, resistant skin vasculitis plasmapheresis could be a choice of treatment.
INSTAGRAM Y DERECHO: LAS TIC COMO HERRAMIENTAS DE INNOVACIÓN DOCENTE
Authors: Simó Soler Elisa
Published: December 2022

La incorporación de las tecnologías digitales en la educación universitaria deviene un requisito ineludible. La presencia de dispositivos electrónicos en las aulas y la impartición de docencia a una generación nativa digital, fija las condiciones materiales para el empleo de Tecnologías de la Información y la Comunicación en Derecho. La iniciativa de integrar Instagram como herramienta de aprendizaje en el grado en Derecho se justifica tanto por su adaptabilidad como por los índices de uso en las franjas de edad del alumnado. En particular, el perfil @miopiajudicial surge como canal de divulgación jurídica y repositorio virtual de cuestiones relacionadas con la visibilización de estereotipos de género en la Administración de Justicia. Su implementación como proyecto piloto abre una ventana de oportunidad a su inserción en el sistema de aprendizaje-enseñanza del Derecho incitando a la participación del estudiantado. La creación de una publicación en Instagram exige la adquisición y puesta en práctica de un conjunto de competencias y habilidades que no solo la Facultad debe transmitir, sino que son de plena utilidad para el ejercicio posterior de las profesiones jurídicas (búsqueda de resoluciones judiciales, precisión terminológica, síntesis de conceptos, argumentación escrita, exposición oral, entre otras). Pese a la inversión de tiempo y la complejidad de traducir conceptos a un lenguaje inteligible, la versatilidad, la multidisciplinariedad y la interacción que la red social proporciona constituyen beneficios suficientes para superar los inconvenientes iniciales que se verán reducidos por la propia dinámica de trabajo. Frente a la memorística individual irreductible, Instagram ofrece la posibilidad de un aprendizaje cooperativo sobre cuestiones prácticas, además del impacto social por la difusión de conocimiento.
LECTURA Y EDUCACIÓN: HÁBITOS LECTORES EN LOS CENTROS DE SECUNDARIA DE GALICIA
Authors: Vega Gemma R.
Published: December 2022

La competencia lectora supone una parte fundamental para el desarrollo del pensamiento crítico de los jóvenes. Considerando esta premisa, este artículo recoge los resultados de una investigación, de enfoque cuantitativo, dedicada a conocer los hábitos lectores de una muestra representativa de estudiantes de Educación Secundaria Obligatoria y de Bachillerato en cuatro contextos educativos diferentes localizados en Galicia. El estudio se ha centrado, sobre todo, en el análisis de las prácticas lectoras a partir de los catorce años, una edad, según indica el Barómetro de Hábitos de Lectura y Compra de Libros (elaborado por la Federación de Gremios de Editores de España con el respaldo del Ministerio de Cultura y Deportes), en la que comienza a decaer el interés por la lectura. Se realizó un estudio, de corte transversal, empleando para la recogida de datos un cuestionario. Una vez obtenidos los resultados, se observa una afección creciente por la lectura por parte del alumnado encuestado. En contraste, los adolescentes gallegos no son lectores frecuentes y manifiestan que el tiempo dedicado a la lectura no es motivado por su propia elección, sino que les viene como una imposición exógena. Se concluye promoviendo la necesidad de combinar la lectura impuesta con la lectura libre.
La didáctica de la Historia desde la fragmentación y la instrumentalización: Un estudio de caso a partir del desarrollo de la conciencia histórica en el BEESEC, Universidad Nacional, Costa Rica (2021)
Authors: Esquivel Vega Jeffry Aurelio , Campos Fonseca Gustavo Adolfo , Jiménez Álvarez Dennis Josué
Published: December 2022

The objective of this article is to analyze the teaching and learning processes present in the experiences of the initial training of people graduating from the baccalaureate in Social Studies and Civic Education of the UNA related to historical awareness. It was based on theoretical postulates on historical consciousness and historical narratives by Rüssen and Plá respectively, as well as the ideas on initial teacher training and didactics of history proposed by Ramírez, Pagès, Benejam and Plá. The methodology was centered within the qualitative paradigm with a phenomenal approach, since the study subjects were eight people graduated from BEESEC in the year 2021. It was concluded that the study subjects were permeated by a fragmented discourse between the notions of teaching and the historical content, due to the influence of the practices and speeches given during the classes of the curricular framework.
FROM THE RULE OF LAW TO ECONOMIC EFFICIENCY AND INCREASING LEVEL OF LIVING: ECONOMIC AND LEGAL ANALYSIS (THE THEORETICAL ASPECT)
Authors: SEREDA V.
Published: December 2022

Introduction. Today, overcoming income inequality and poverty is the basis of sustainable development. Against the background of the actualization of innovations, the scientometric substantiation of the doctrinal role of the rule of law on the interdisciplinary basis of law and the economy of innovations as a rudder of equal access of actors toeconomic chances is an essential component of the economic and legal platform of effective economic dynamics.Problem Statement. The vector of research is the identification of modern key factors influencing the rule oflaw on the economic levers of forming an economic and legal platform for effective economic dynamics and forreducing income inequality.Purpose. Economic and legal analysis of the concept of the rule of law, substantiation of its driving force foreffective economic dynamics and welfare growth.Material and Methods. The basis of the research methodology is the anthropological axis of the researchdiscourse.Analytical, historical and method of retrospective analysis of scientometric theoretical works, forecasting, economic and legal analysis, empirical method.Results. A vector for the development of an interdisciplinary economic and legal concept of promoting the rule of law for the effectiveness of economic dynamics in the information economy with a view to improving welfare by activating the quality of human capital has been initiated.Conclusions. Scientific and theoretical dynamics of the conceptual basis of the rule of law on a cross-sectoralbasis of law and economics as a driver of equal access of actors to economic opportunities, innovation, entrepreneurship is an important component of effective economic and legal platform for the modern domestic development and the overcoming of inequality.
Atrial fibrillation in a patient with lung cancer: a case report
Authors: Shupenina E. Yu. , Vyzhigin D. I. , Gaganov L. E. , Novosel E. O.
Published: December 2022

Introduction. Cancer remains one of the most common causes of death in the world, second only to cardiovascular diseases. The use of novel chemotherapeutic and targeted agents has significantly improved the prognosis of this group of patients. However, this significantly increased the number of cardiotoxic complications of anticancer therapy, including arrhythmias, in particular atrial fibrillation (AF), which negatively affects the prognosis.

Brief description. The purpose of this article was to describe the case of a 64-yearold woman with central right lung lower lobe cancer. Upon admission to the chemotherapy department, the patient was first diagnosed with paroxysmal AF. After chemical cardioversion, the first course of multiagent chemotherapy (MAC) was performed as follows: paclitaxel 280 mg and carboplatin 450 mg, which was complicated by the development of recurrent AF episode. During subsequent MAC courses, arrhythmia episodes regularly occurred. During the next AF episode, the patient was hospitalized at the City Clinical Hospital № 51, where she died despite intensive therapy. Postmortem examination ruled out tumor invasion into the left atrium.

Discussion. For the AF development, the patient had prerequisites in the form of a significantly remodeled left atrial myocardium. Chemotherapy agents used as antitumor therapy are characterized by the common development of cardiotoxicity, including variety of arrhythmias. The occurrence of AF episodes coincided with the course of MAC, which suggested its cardiotoxic manifestations. Postmortem examination confirmed the high probability of an association between AF episodes and MAC.

Conclusion. The presented case illustrates the difficulties encountered by oncologists and cardiologists in determining the genesis and treatment of complex arrhythmias in cancer patients.
Results of thrombectomy in lower-extremity ischemia in patients with COVID-19 and respiratory failure of different severity
Authors: Polyanskaya E. A. , Sidorova K. V. , Oberina A. P. , Lider R. Yu. , Korotkikh A. V. , Beglaryan Zh. G. , Snigur A. A. , Mukhtorov O. Sh. , Lebedev O. V. , Golokhvastov S. V. , Artyukhov S. V. , Ageev I. I. , Rogova А. А. , Kalichkin I. A. , Kazantsev A. N.
Published: December 2022

Aim. To analyze the results of thrombectomy in lower-extremity ischemia in patients with coronavirus disease 2019 (COVID-19) and respiratory failure of different severity.

Material and methods. This retrospective, cohort, comparative study for the period from May 1, 2020 to March 1, 2022 included 305 patients with acute lower-extremity ischemia and COVID-19. Depending on the type of oxygen support, three groups of patients were formed: group 1 (n=168) — nasal oxygen insufflation; group 2 (n=92) — non-invasive ventilation (NIV); group 3 (n=45) — artificial ventilation (AV). Thrombectomy was carried out according to the standard technique using Fogarty catheters (3F-6F — depending on the vessel size). After the diagnosis was established before and after the start of surgical treatment, all patients received the following therapy: Unfractionated IV heparin infusion at an initial rate of 1000 U/r, adjusted to maintain the activated partial thromboplastin time at 2-3 times the normal value; 2. Oral acetylsalicylic acid 125 mg; 3. Analgesics.

Results. Myocardial infarction and ischemic stroke were not detected in the total sample. The highest number of deaths (group 1: 5,3%, n=9; group 2: 72,8%, n=67; group 3: 100%, n=45; p<0,0001), retrombosis (group 1 : 18,4%, n=31; group 2: 69,5%, n=64; group 3: 91,1%, n=41; p<0,0001) and limb amputations (group 1: 9,5%, n=16; group 2: 56,5%, n=52; group 3: 91,1%, n=41; p<0,0001) was recorded in group 3 patients.

Conclusion. In patients receiving mechanical ventilation, COVID-19 have more aggressive course, which is expressed in an increase in laboratory para- meters (C-reactive protein, ferritin, interleukin-6, D-dimer), the severity of pneumonia and location of thrombosis in the tibial arteries. Among patients with COVID-19 receiving mechanical ventilation, the greatest number of rethromboses (91,1%), limb amputations (91,1%), and deaths (100%) are noted, which suggests the expediency of abandoning open thrombectomy in favor of anticoagulant/antiplatelet therapy in this cohort of patients. The development of arterial thrombosis in patients with COVID-19 receiving mechanical ventilation is an indicator of a high risk of death. Open thrombectomy in combination with anticoagulant/antiplatelet therapy is most effective in patients on nasal oxygen insufflation or NIV.
Russian consensus statement on the diagnosis and treatment of patients with carotid stenosis
Authors: Chernyavsky M. A. , Irtyuga O. B. , Yanishevsky S. N. , Alieva A. S. , Samochernykh K. A. , Abramov K. B. , Vavilova T. V. , Lukyanchikov V. A. , Kurapeev D. I. , Vanyurkin A. G. , Chernova D. V. , Shelukhanov N. K. , Kozlyonok А. V. , Kavteladze Z. A. , Malevanny M. V. , Vinogradov R. A. , Khafizov T. N. , Ivanova G. E. , Zhukovskaya N. V. , Fokin A. A. , Ignatiev I. M. , Karpenko A. A. , Ignatenko P. V. , Astapov D. A. , Semenov V. Yu. , Porkhanov V. A. , Krylov V. V. , Usachev D. Yu. , Svetlikov A. V. , Alekyan B. G. , Akchurin R. S. , Chernyavsky A. M. , Konradi A. O. , Shlyakhto E. V.
Published: December 2022

Carotid stenosis is a multidisciplinary problem that requires the involvement of a specialists’ team, including cardiovascular surgeons, neurosurgeons, endovascular surgeons, cardiologists, neurologists, and internists. In this consensus statement, a group of experts considered the main stages of diagnosing carotid stenosis, as well as discussed, the necessary prevention methods and features of choosing the optimal treatment approach. The aim was to provide concise and structured information on the management of patients with carotid stenosis. This document was developed based on the updated clinical guidelines of the European Society for Vascular Surgery and the American Association for Vascular Surgery, taking into account the consensus opinion of Russian experts.
Therapy for hypertension and dyslipidemia: potential of Lipertans (on the example of a clinical observation)
Authors: Kashtalap V. V.
Published: December 2022

The article presents epidemiological data on the high prevalence of hypertension and dyslipidemia comorbidity in the general population, as well as shows the leading role of these key cardiovascular risk factors in the development of cardiovascular events. At the same time, within the primary prevention, the adherence of patients to the lipid-lowering therapy remains low. Fixed-dose combinations (Lipertans) based on antihypertensive (amlodipine, perindopril) and lipid-lowering drugs (atorvastatin) can significantly increase the effectiveness of therapy.
Revisão sistemática de células solares de silício base n: estruturas e eficiências
Authors: Vanzetto A. B. , Moehlecke A. , Crestani T. , Britto J. V. Z. , Zanesco I.
Published: December 2022

Resumo Células solares com emissor e face posterior passivada (PERC, passivated emitter and rear cell) vêm dominando o mercado fotovoltaico em razão de seu processo de fabricação ser compatível com as linhas industriais que vinham sendo utilizadas e pela produção de dispositivos de alta eficiência. Atualmente o silício tipo p é o mais utilizado pela indústria de células solares, mas o silício tipo n deve ganhar mercado nos próximos anos juntamente com o emprego de lâminas de espessura reduzida. O objetivo deste trabalho é apresentar uma revisão sistemática dos principais estudos na área de células solares base n, sendo elas do tipo PERC, PERT (passivated emitter-rear totally diffused) e TOPCon (tunnel oxide passivated contact), com ênfase para a abordagem de contatos seletivos, emissores seletivos e nos processos utilizados, bem como na análise de células solares de espessura reduzida em relação ao padrão da indústria atual.
Teacher education practices of an experienced teacher in an induction program: a case study
Authors: Reali Aline Maria de Medeiros Rodrigues , Souza Ana Paula Gestoso de
Published: December 2022

Abstract Considering the theoretical references on the teaching knowledge base, conversations between teachers, and the teacher's thoughts, we analyze the formative practice of an experienced teacher while acting as a mentor to a novice teacher in an induction program. We conducted a descriptive-analytical exploratory case study about the virtual interactions established between them. The analysis of the mentor’s written narrative unveils her pedagogical reasoning through several formative actions related to the novice. The analysis of the mentor's written narratives revealed her pedagogical reasoning through several formative actions related to the novices' practices and the problems she faced. The reflective processes encouraged the mentee to look at her practice, design alternative ways of acting, and implement them
Uma análise exploratória sobre seleção e inclusão no Ensino Superior brasileiro: do mérito herdado ao mérito relacional
Authors: Barbosa Maria Lígia de Oliveira , Pires André
Published: December 2022

Resumo Este artigo tem por objetivo propor uma análise exploratória sobre os sentidos do mérito nas políticas de inclusão no ensino superior brasileiro. O estudo focaliza o Enem, o Sistema de Seleção Unificada (Sisu), a Lei de Cotas de 2012 e o Programa de Inclusão com Mérito no Ensino Superior Público Paulista (PIMESP) das Universidades Estaduais Paulistas. O texto inicia-se com uma discussão sobre o mérito, a partir de produções clássicas e contemporâneas, para tratar, em seguida, das mudanças ocorridas nos princípios organizadores das políticas de seleção e acesso ao ensino, que passaram do mérito universal ao mérito relacional. A terceira parte trata de algumas ações institucionais que conjugaram o ENEM, a Lei de Cotas de 2012 e o Sisu como exemplos de articulação entre o mérito universal e o relacional no ingresso. O Pimesp, ao abolir critérios vinculados ao mérito relacional, acabou sendo objeto de muitas críticas. O artigo destaca a necessidade de que a revisão da referida Lei de Cotas, prevista para 2022, preserve este importante mecanismo de inclusão. A expansão do ingresso no ensino superior traz também desafios em relação às políticas de permanência e de egressos para que estas levem em conta a dimensão relacional do mérito.
Higher Education internationalization: how do Education field studies address the topic?
Authors: Moreira Claudia Regina Baukat Silveira , Ribeiro Mariana Pires
Published: December 2022

Abstract Arguing that the early 21st century saw an important push to higher education internationalization, this study shows the results of a bibliographical review on the topic. To do so, a set of 36 articles, published between 2014 and 2019, in education journals of excellence were selected via specific research descriptors. From our analysis it seems that, although most articles can be categorized either from the perspective of students’ experiences or from a public policy to internationalize higher education, we find great porosity in addressing the theme, which hinders summarization.
Variability in quantitative parameters of instrumental swallowing assessments: a scoping review protocol
Authors: Bandeira Jayne de Freitas , Magalhães Desiré Dominique Diniz de , Pernambuco Leandro de Araújo
Published: December 2022

ABSTRACT Purpose: to present a scoping review protocol mapping scientific evidence on the level of variability in quantitative parameters or outcomes extracted with instrumental swallowing examinations. Methods: a protocol following the methodological approach designed by the Joanna Briggs Institute and the scoping review recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols - extension for scoping reviews (PRISMA-ScR). The search will be made in PubMed/MEDLINE, LILACS, Cochrane Library, EMBASE, Web of Science, Scopus, and CINAHL and the grey literature (Google Scholar and ProQuest) with a search strategy developed for PubMed/MEDLINE, adapted for each database. Two independent reviewers will initially select articles by title and abstract, and the full text of the selected ones will be read and analyzed according to the eligibility criteria. Data will be extracted from the selected articles in a standardized form, and the results will be presented in a flowchart and narrative summary, following PRISMA-ScR guidelines. Final considerations: the scoping review resulting from this protocol is expected to present the overall state of the scientific evidence and identify gaps in the topic that need to be addressed in studies.
Fonoaudiologia em estética da face: efeito de duas estratégias para musculatura supra-hioidea
Authors: Ferreira Daniele Barreto da Cunha , Furlan Renata Maria Moreira Moraes , Frazão Yasmin Salles , Motta Andréa Rodrigues
Published: December 2022

RESUMO Objetivo: verificar os efeitos do exercício de pressão de língua contra a papila incisiva, realizado de forma isolada e associada ao treino funcional da deglutição, na atividade elétrica da musculatura supra-hioidea e na autopercepção da mudança estética na região submandibular. Métodos: estudo experimental, analítico e prospectivo, realizado com 27 mulheres entre 30 e 78 anos, divididas em dois grupos de tratamento (G1 e G2) e um grupo controle (GC). Os indivíduos foram submetidos a oito semanas de treinamento, sendo que o G1 realizou somente o exercício pressão de língua contra a papila incisiva, o G2 realizou o mesmo exercício associado ao treino da deglutição e o GC não foi submetido a qualquer intervenção. A atividade elétrica da musculatura supra-hioidea foi obtida por meio da eletromiografia de superfície no início e ao final do estudo, quando também foi aplicado um questionário de autopercepção dos possíveis resultados estéticos obtidos. Foram utilizados os testes Qui-quadrado de Pearson, Exato de Fisher, Mann Whitney, Kruskal Wallis e Wilcoxon, com nível de significância de 5%. Resultados: foram encontradas diferenças estatisticamente significativas na atividade elétrica entre os valores inicial e final tanto no G1 quanto no G2, fato não observado no GC. Não houve diferença significativa entre os grupos em relação à autopercepção da melhora visual e da melhora muscular. Conclusão: as duas estratégias analisadas mostraram-se igualmente eficazes para promover o maior recrutamento da musculatura supra-hioidea, porém, sem impacto na autopercepção da mudança estética na região submandibular.
Estilo e formação na filosofia do jovem Nietzsche: o caso Schopenhauer
Authors: Gonçalves Alexander
Published: December 2022

Resumo: O escopo desta investigação consiste em averiguar em que medida o estilo (Stil), para o jovem Nietzsche, consiste num meio através do qual o filósofo realiza a suprema tarefa da filosofia: a formação (Bildung). Parto da afirmação de que o problema estilístico compõe um dos principais elementos da avaliação que o jovem filósofo faz da formação e da cultura (Kultur) alemãs de seu tempo para, por fim, apresentar de que modo Nietzsche encontra no caráter extemporâneo do estilo e da filosofia de Schopenhauer o caminho para a superação da barbárie (Barbarei).
O jovem e a formação (Bildung) do gênio no jovem Nietzsche
Authors: Carvalho Cassiano Lucas Silva
Published: December 2022

Resumo: O objetivo deste artigo consiste em investigar qual seria o papel do jovem nas críticas do jovem Nietzsche à cultura alemã nas Considerações Extemporâneas. Em um primeiro momento, investigaremos sob o viés da formação (Bildung) de que maneira o jovem pode contribuir para a cultura. Nesse sentido, investigaremos a hipótese de que o jovem possui algum tipo de relação com a formação (Bildung) do gênio.
Relação entre educação, cultura e vida para o professor Nietzsche
Authors: Benvenho Célia Machado
Published: December 2022

Resumo: As reflexões de Nietzsche sobre a educação e a cultura alemã de sua época surgem no contexto em que ele, como professor, está envolvido diretamente com essas questões. Elas podem ser encontradas especialmente em dois trabalhos desse período: nas Conferências sobre o futuro de nossos estabelecimentos de formação, de 1872, e na Terceira Consideração Extemporânea: Schopenhauer como educador, de 1874. Interessa-nos, nesses textos, identificar as críticas que Nietzsche faz à educação de seu tempo e analisar sua “proposta educativa” em que educação, vida e cultura se encontram estreitamente vinculadas a ponto de promoveram uma cultura autêntica.
Family and Community Medicine Residency: graduates’ insights about their education and work process
Authors: Cavalcante Gecilda Régia Ramalho Vale , Cavalcante Rafael Ramalho Vale , Trindade Thiago Gomes da , Oliveira Felipe Proenço de , Pessoa Talitha Rodrigues Ribeiro Fernandes
Published: December 2022

The article analyzed how the Residency in Family and Community Medicine (RFCM) in a capital of the Northern region of Brazil contributed to the formation and development of the current work process of its graduates. This is an exploratory, descriptive and cross-sectional study, with a qualitative approach focused on 31 graduates, through electronic questionnaires with open questions. The answers were interpreted based on the Content Analysis Thematic technique, constituting four empirical categories: training in Family and Community Medicine (FCM) in the graduate’s work process; recognition and application of the attributes of Primary Health Care (PHC); potentials of the FCM training and the challenges of the specialty. The analyzed data show that the studied Programs contribute to the education for professional practice and the profile of its graduates through the strengthening and implementation of the Primary Health Care (PHC) attributes, also extending beyond the specialty.
Application of graphene oxide as (nano) reinforcement in epoxy composites
Authors: Edwards Elilton Rodrigues , Almeida Érica Cristina , Santos Marivaldo Batista dos , Oliveira Alan Santos
Published: December 2022

ABSTRACT Composite with nanometric particles have been used as a structural reinforcement to improve the mechanical properties in polymeric materials. The use of graphene has shown excellent results such as Young's modulus of 1 TPa, tensile strength of about 130 GPa, thermal conductivity of 5000 W/mK, electrical conductivity of up to 6000 S/cm, in addition to presenting great carrier mobility of loads of 2x105 cm2.V-1.s-1. Thus, the mechanical properties in the epoxy resin based on diglycidyl ether of bisphenol A were evaluated with the addition of increasing percentages of graphene oxide (GO) in order to evaluate the mechanical properties in this material. The synthesis of GO was made from natural graphite by the Hummers method. The nanostructured composites were manufactured with a mixture of 0.1%, 0.2%, 0.5% and 1% by weight of GO. The characterizations of the materials were made by FTIR-ATR, DRX, RAMAN, MEV and TGA. The mechanical properties were evaluated by increasing the impact energy Izod absorbed in composites with lower GO content. The results showed that with the increase in the amount of graphene oxide there was an increase in the mechanical properties and that the increase in the OG charge in the matrix generated agglomerations, impairing the impact absorption in the mechanical properties of the material making it necessary a rigorous process of dispersion of these nanometric materials in the polymeric matrix.
IMPACT OF COVID-19 LOCKDOWN PRECAUTIONS ON AIR POLLUTANTS IN TURKEY
Authors: GÜNEŞ DURAK Sevgi
Published: December 2022

Due to the COVID-19 pandemic, the precautions taken in the early period of the pandemic have had a significant impact on the reduction of air pollutants. In this research, the changes in the concentrations of some air pollutants (PM10, NO2, SO2, CO, O3) concentrations have been investigated and evaluated between March 15 - May 31, 2019 and March 15 - May 31, 2020 in Turkey. According to the results, PM10, NO2 and SO2 concentrations decreased by up to 75%, 80% and 77% respectively. However, there has been an increase in CO and O3 concentrations in many cities. Pearson’s correlation analysis showed that there is a strong relevance between NO2 - CO and O3 - CO concentrations in the lockdown period. In addition, with the precautions, the positive correlation between PM10 and NO2 and between SO2 and CO increased, and the negative correlation between PM10 and O3 decreased.
BETONARME KİRİŞLERİN DAVRANIŞINI ETKİLEYEN PARAMETRELERİN DENEYSEL İNCELENMESİ
Authors: ESEN Barış , GÜNDOĞAY Abdullah , YAMAN Sıla , TEKELİ KABAŞ Hamide , DEMİR Fuat
Published: December 2022

Kiriş elemanlar, döşemelerden gelen düşey yükler ile deprem, rüzgar yükü gibi yatay yüklerin kolon elemanlara aktarılmasını sağlarlar. Dolayısıyla kirişlerin kapasite değerlerine etki eden parametrelerin net olarak ortaya konulması, kolonların kapasitesinin belirlenmesi kadar önem taşımaktadır. Ülkemizdeki mevcut betonarme binaların büyük çoğunluğunda beton basınç dayanımının proje dayanımından düşük olması, çekme donatısı oranının ve etriye aralığının yönetmeliklerde verilen sınır değerlere uygun olmaması karşılaşılan temel kusurlar arasında sayılabilir. Bu çalışmada, kiriş elemanlarda, beton dayanımı, çekme donatısı miktarı ve etriye aralığı parametrelerinin kiriş kapasitesi üzerindeki etkisi ½ ölçekli 16 adet betonarme kiriş numune üzerinde deneysel olarak incelenmiştir. Numuneler üç noktalı eğilme testine maruz bırakılmış ve her bir numunenin yük taşıma kapasitesi, sünekliği, enerji tüketme kapasitesi ve rijitliği hesaplanarak yorumlanmıştır. Literatürde özellikle çok düşük beton basınç dayanımına sahip kirişlerin deneysel çalışmaları oldukça az sayıdadır. Bu nedenle yapılan çalışma kapsamında üç farklı seviyede düşük beton dayanımı dikkate alınmıştır. Elde edilen sonuçlardan beton dayanımının 5 MPa olan numunede etriye sıklaştırmasının davranış açısından çok katkısı bulunmazken, 7 ve 9 MPa beton dayanımına sahip numunelerde hasarın daha ileri aşamalara taşınmasında katkı sağladığı görülmüştür.
OPTIMUM DESIGN OF THERMO-PLUNGER SUPPORT IN COMMERCIAL VEHICLES BY USING STRUCTURAL DESIGN AND FINITE ELEMENT METHODS
Authors: KILIÇARPA Ulaş Aytaç , YILDIZ Betül Sultan , YILDIZ Ali Rıza
Published: December 2022

This paper focuses on creating an optimum design and development of thermo-plunger parts for commercial vehicles in order to save material, reduce mass and make more sustainable automobiles. In this paper, natural frequency analysis, topology, and topography optimization methods have been used to create a new design for the thermo-plunger part. Thermo-plunger means an electric heater that is used for heating the inside of automobiles effectively and quickly and providing customer thermal comfort. It is positioned in the vehicle body, and its support parts have been developed by structural optimization techniques because there is not enough space in the engine compartment for automatic transmission commercial vehicles. The aim of this study is to make a lightweight and reinforced thermo-plunger support part design. Initially, a draft design was created in 3D model software. After that, topology and topography optimizations were applied on this draft design. At the end of studies, a final optimum support design has been obtained. The final design is 41.1% lighter than the initial design. At the same time, above 50 Hz natural frequency value has been obtained on the final design to avoid resonance problems.