bluuebunny/crossref_metadata_2025 huggingface dataset:
A Critical Review on Prescribing Pattern Monitoring of Neurological Disorders in a Tertiary Care Teaching Hospital
Authors: Chauhan Puneet , Tantray Junaid , Kosey Dr. Sourabh
Published: October 2022

Neurological diseases have a significant impact on global health. According to the most recent estimates, the neurological disorders included in the Global Burden of Disease (GBD) Study—and Alzheimer's other dementias, Parkinson's disease, multiple sclerosis, epilepsy, and headache disorders (migraine, tension-type headache [TTH], and medication-overuse headache [MOH]—represent 3% of the global disease burden. [1] Prescription pattern monitoring studies (PPMS) are drug use studies that concentrate on prescription prescribing, dispensing, and administration. They advocate for the proper use of controlled substances and the decrease of drug addiction or misuse. Neurological problems impact around 100 million individuals worldwide. In developing nations, where the prevalence of Polypharmacy, excessive antibiotic usage, injections, "off-label" medication use, and ineffective treatments is high, irrational drug use is a widespread problem. Numerous studies have documented prescription data practices among adults in different countries. But there is still the lack of information on the prescribing practices in neurology. Drugs administered to paediatric population suffering from neurological disorders are the same as those for adults/geriatric population that were originally formulated. However, in addition to the disease profile, growth and development processes in patients suffering from neurological disorders may subject them to multiple adverse effects. . It is important to monitor the patient to ensure drug compliance and avoid relapse. People with excellent educational backgrounds were aware of the early signs and risk factors for stroke. The standard WHO prescription standards were followed by effective prescribing practises. Instead of using the recommended generic names, brand-name prescriptions of drugs raise concerns.

Keywords: Drug auditing, drug utilization pattern, pharmacoepidemiology, prescription-monitoring, rational use of drugs.
Effect of Aerobic Exercise versus Jacobson’s Progressive Muscular Relaxation Technique in Patients with Hypertension
Authors: Vaishya Avsar Rameshkumar , Shukla Yagna Unmesh , Bhise Anjali
Published: October 2022

Introduction: In the last few decades, the prevalence of hypertension has been drastically increased in India. Hypertension is defined by the presence of a chronic elevation of systemic arterial pressure above a certain threshold value. Proper management of hypertension may require both pharmacological and non-pharmacological interventions. Aerobic exercise and Jacobson’s Progressive Muscular relaxation (JPMR) technique both are Non-pharmacological interventions for reducing blood pressure.
Method: Interventional study was done by Random sampling method and conducted on 20 hypertensive subjects. Subject willing to participate, age group 20-55 year both male and female and blood pressure above 140/90 mmHg were included. Subjects not able to understand, psychologically unstable, systemic illness and subject who were not regularly taking medications were excluded. 20 hypertensive subjects, randomly divided into 2 groups. The first group was asked to do 5 sessions of Aerobic exercise for 30-45 minutes per week for 4 week and the second group was asked to do 5 sessions of JPMR for 30 minutes per week for 4 week. In both the groups pre and post systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were measured in sitting position. Subjective results were established.
Results: Statistical analysis was done using SPSS16. There was statistically significant difference between pre and post value of SBP (p<0.05), DBP (p<0.05) in both groups, but the aerobic exercise showed more significant results as compared to the JPMR.
Conclusion: Hence it can be concluded that Aerobic Exercise is more effective in hypertensive than Jacobson’s Progressive Muscular relaxation technique.

Keywords: Aerobic Exercise, Jacobson’s Progressive Muscular relaxation technique (JPMR), hypertension
KEGIATAN PENYULUHAN TENTANG WEBINAR FARMAKOTERAPI PENGENALAN PENYAKIT HIPERTENSI
Authors: Ramatillah Diah , Jiman Hugolia Cerlin , Jiman Hugolia Cerlin , Hutasoit Rosida Susanti , Hutasoit Rosida Susanti , Janati Aqnan , Janati Aqnan , Lubis Nora Sari , Lubis Nora Sari , Fauziah Nurul , Fauziah Nurul , Fadilah Shelly Nur , Fadilah Shelly Nur
Published: October 2022

ABSTRAKHipertensi merupakan suatu keadaan meningkatnya tekanan darah sistolik lebih dari sama dengan 140 mmHg dan diastolik lebih dari sama dengan 90 mmHg. Hipertensi belum diketahui faktor penyebabnya, namun ditemukan beberapa faktor risiko. Tujuan penyuluhan adalah untuk mengetahui tingkat pengetahuan tentang penyakit hipertensi, untuk mengetahui tatalaksana pengobatan dan pencegahan atau penanggulangan sebab terjadinya penyakit hipertensi, untuk mengedukasi kepada masyarakat agar dapat menjaga pola hidup sehat sebagai tindakan prevensi hipertensi. Kegiatan dalam penyuluhan ini berbentuk penyampaian materi dalam pentingnya pengenalan penyakit hipertensi kepada masyarakat di Desa Meler dengan menggunakan aplikasi zoom dengan media presentasi power point. Dari hasil penyuluhan, diketahui peserta penyuluhan sudah memahami tentang pentingnya pengenalan penyakit hipertensi.Kata kunci : Webinar, Hipertensi, Pengenalan
A Canaanite’s Wish to Eradicate Lice on an Inscribed Ivory Comb from Lachish
Authors: Vainstub Daniel , Mumcuoglu Madeleine , Hasel Michael , Hesler Katherine , Lavi Miriam , Rabinovich Rivka , Goren Yuval , Garfinkel Yosef
Published: October 2022

An inscription in early Canaanite script from Lachish, incised on an ivory comb, is presented. The 17 letters, in early pictographic style, form seven words expressing a plea against lice.
Physico-Chemical and Metal Composition of Some Sachet and Borehole Water in Imota Community Area of Lagos State, Nigeria
Authors: M.M. Adeyemi , I.O. Olayemi , A.O. Olemoh , F. Abegunde
Published: October 2022

The accessibility of quality water is an essential factor for preventing diseases and improving good quality of life. The physico-chemical parameters of sachet and borehole water in some selected locations of Imota Community of Lagos State was studied. Physico-chemical parameters such as colour, temperature, pH, salinity, electrical conductivity (EC), total dissolved solids (TDS) and heavy metals such as copper, magnesium, manganese and cadmium were determined following standard methods. All water samples were colourlesss with a temperature range of 27.1oC to 29oC at the point of collection. The physico-chemical properties ranges were: salinity (0.01–3.8), pH (2.10–7.52), electrical conductivity (1.5–200 μS/cm), micro voltage (22.7–184) and total dissolved solids (19.8–576 mg/L). Caleb University Ventures water was the only sample with a neutral pH of 7.52. The concentrations of metals in the selected water samples were within the permissible limit of USEPA (2022) and WHO (2017) guidelines. The study showed that physical water quality parameters such as pH, salinity, EC and TDS have variations at different locations, which suggests that different soil types, storage systems and environmental activities could interfere with the physico-chemical parameters. The water samples from Imota Community had low level of pollutants as indicated by the physico-chemical properties of the water. However, standard methods of water treatment should be maintained by the community to ensure the purity of water available for domestic use, so that problems commonly associated with impure and unclean water can be averted.
Isolation and Identification of Antioxidant and α-glucosidase Inhibitor Compound from Prospective Extract of Acacia Bark from Indonesia
Authors: I. Aulia Muhammad , K. Sari Rita , S. Nawawi Deded , T. Dewi Rizna
Published: October 2022

Tropical forests in Indonesia have a great diversity of plants. Among those species, Acacia is a plant that is widely found in Indonesia. The utilization of Acacia in Indonesia increases the amount of bark waste in the harvesting process. The aim of the research was to obtain prospective extracts the bark of A. mangium, A. auriculiformis, and A. crassicarpa based on antioxidant activity, α-glucosidase inhibition assay, and to identify compound in the prospective extract. In this research, the methods used to determine antioxidant were used 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), antioxidant Ferric Reducing power (FRAP), and assays for the total levels of phenolic compounds and flavonoids in each extract. To determine antidiabetic, a test was carried out by examining the α-glucosidase inhibition of the α-glucosidase enzyme from Sachamyce cerevisiae. Then the prospective extracts were identified using Liquid Chromatography-Mass Spectrometry (LC-MS) and Nuclear Magnetic Resonance (NMR) (1H and 13C). Based on the test results, Acacia mangium methanol extract showed the best activity for testing. Separation and further purification of A. mangium extract obtained sub-fraction 6 (isolate 1) which was identified as scopoletin and shows the α-glucosidase inhibition at 96,84%. Based on the results of this research, A. mangium has the potential as a source of medicinal ingredients, and it is suggested to conduct further research to isolate other active compounds.
Quantitative and Qualitative Evaluation of Leaf Essential Oil in Micropropagated Hedychium coronarium - An Endangered Medicinal Plant
Authors: Parida Reena , Nayak Sanghamitra
Published: October 2022

In India, morever medicinal plants are collected from the forests and are used by industries in the preparation of medicines. Hedychium coronarium or white ginger lily is an endangered plant of family Zingiberaceae. In international market the price of its plant essential oil is $62/1000ml. The high interest for natural treatment of diseases is creating a challenge between demand of plant based medicines availability in markets and the need for biodiversity and conservation of these medicinal plants. Therefore in vitro method is adapted for conservation and secondary metabolite extraction of this plant throughout the year. In the present work, the explant was regenerated on Murashige and Skoog basal media and study was done on in vitro cultures of Hedychium in different lines of growth regulators to estimate the quantity and quality of leaf essential oil comparing with its mother plant. The present protocol reports somaclone rich in caryophyllene and eucalyptol that could be analyzed further for use in large scale production and commercial exploitation.
In-silico Profiling of Deleterious Non Synonymous SNPs of Homogentisate 1, 2 Dioxygenase (HGD) Gene for Early Diagnosis of “Alkaptonuria”
Authors: V. Nagalakshmi , J. Lavanya , B. Bhavya , V. Riya , B. Venugopal , A. Sai Ramesh
Published: October 2022

In-silico characterization and molecular modelling of a single amino acid substitution in HGD (Homogentisate 1,2dioxygenase) gene are mainly caused by the deficiency of enzyme Homogentisate 1,2dioxygenase (HGD). An enzyme HGD involved in the catabolism of amino acids such as tyrosine and phenylalanine. The objective of this study was to analyse non-synonymous SNPs from highly deleterious missense mutations which affect the protein function of HGD gene. Based on 3D structure different computational algorithms were performed to identify deleterious SNPs and assess the influence of mutation by using molecular dynamics simulations and molecular docking. Bioinformatics analysis like SIFT, PolyPhen 2.0, I mutant 3.0, PANTHER, SNPs and GO were performed to predict non deleterious ns-SNPs from missense mutations. Energy minimization was done by using GROMACS followed by RMSD calculations and free-energy values under SWISS-PDB viewer and PyMoL respectively. Later, Trajectory analysis was performed using computational tools like SRIDE, CONSURF, SPPIDER, PSIPRED, FLEXPRED for predicting the probably damaged ns-SNPs. Moreover, molecular docking was performed and identified highly deleterious probably damaging mutation. By operating 10 bioinformatics analysis, we obtained 5 mutations R53W, L61P, G121R, G361R and L430H which have an adverse effect on HGD gene. The results of the ConSurf analysis showed that all of these ns-SNPs are in the highly conserved positions and influence the structure of native proteins. L61P mutation had more effect on protein structure. Later, for future studies these mutations assists to develop an effective drug for the associated disease Alkaptonuria.
Combined Antibacterial activity of Eucalyptol, γ-terpinene, p-cymol and punicalagin with Cefotaxime against Methicillin (Oxacillin) Resistant Staphylococcus aureus Isolate
Authors: Dmour Saif M. , Qaralleh Haitham , Al-Limoun Muhamad , Khleifat Khaled M. , Alqaraleh Moath , Alqudah Ali Abdallah , Altarawneh Rakan M.
Published: October 2022

Resistance to antibiotics is a significant public health issue in preventing infectious diseases. This study was designed to evaluate the antibacterial activity of eucalyptol, γ-terpinene, p-cymol and punicalagin against Methicillin (Oxacillin) resistant strains. The synergistic effect of these compounds with cefotaxime against Staphylococcus aureus was investigated. The lowest MIC value observed was 0.08mg/mL for punicalagin against S. aureus, followed by the MIC values of punicalagin against E. aerogenes, E. coli and K. pneumoniae (0.16 - 0.63mg/mL). The activity of p-cymol against S. aureus is ranked second, as indicated by the MIC value (0.63mg/mL). The results of the combination study showed that the maximum Increase in Folding Area (IFA) was reported when punicalagin was combined with cefoxitin, cefotaxime, oxacillin, and piperacillin. An effective IFA was observed when p-cymol was tested with piperacillin, cefixime, cefotaxime, oxacillin, and cefoxitin. Based on the checkerboard assay, the MIC of cefotaxime decreased from 60 to 7.5µg/mL when combined with punicalagin indicating a significant synergistic effect between cefotaxime and punicalagin against S. aureus. In conclusion, punicalagin improved S. aureus susceptibility to cefotaxime, suggesting that using these two medicines together can reverse beta-lactam resistance in methicillin (oxacillin) resistant S. aureus. Further works are required to generalize this result and then it may be useful for treating diseases caused by methicillin (oxacillin) resistant strains.
In silico and invitro Antidiabetic Characterization and ADME Studies of Rhus parviflora
Authors: Balram Balram , Jalwal Pawan , Singh Gurvirender
Published: October 2022

The study was planned to trace out connection among receptors responsible for the development of diabetes mellitus and active constituents of Rhus parviflora by in silico and in vitro methods. A molecular docking study was carried out for selected compounds after screening of all chemical constituents present in plant. Initial screening was carried through Lipinski’s rule of five along with ADME study of the reported phytoconstituents. For estimation of Antidiabetic potential of all selected constituent total 6 PDB namely 1IR3 (Insulin receptor), 1US0 (Aldose Reductase), 2FV6 (Protein tyrosine phosphatase 1), 2OQV (Human Dipeptidyl Peptidase IV) 2QV4 (α-amylase), 5NN6 (α- glucosidase) were selected. Molegro Virtual Docker tool was employed for the Molecular Docking studies. 4’-O-beta-D-Glucosyl-cis-p-coumaric acid, Kaempferol, Myrecetin, Quercetin, Taxifolin, and Isorhamnetin exhibited efficient hydrogen bonding as well as mol dock score with all selected 6 receptor PDB in contrast to standard drug Glibenclamide. In vitro study results of RPME exhibited 60.58±0.6, 54.64±2.46 percent inhibition in α- Glucosidase Inhibition Assay and α- Amylase Inhibition Assay, in contrast standard acarbose exhibited 71.35±1.84 and 67.76±1.97 percent inhibition respectively. The entire study gives understanding that chosen plant presumably has antidiabetic potential because of considered biomarkers.
Strengthening Awareness of Post-Identity as Asset for Society 5.0 through Reflective Learning
Authors: Tricahyono Danan
Published: October 2022

The background of this article departs from the development of the times that provide opportunities and challenges to humanity in facing the era of society 5.0. The purpose of writing this article is to strengthen post-identity awareness through reflective learning in the subject of civic education (Pkn). The writing of this article uses conceptual ideas. Society 5.0 wants to create a community that truly enjoys life. Social reform in society 5.0 will create an ever-changing society by having foresight, a society that upholds tolerance, and a society where every person can lead an active and enjoyable life. Reflective learning has five hierarchies of thought processes, including 1) reporting, 2) responding, 3) relating, 4) reasoning and 5) reconstructing. Reflective learning strengthens the post-identity awareness of students in the face of the era of society 5.0. Post-identity consciousness has a relationship with the concept of global diversity. To achieve global diversity, students must be able to reflect and be responsible for the experience of diversity and social justice. This post-identity awareness is capital for strengthening tolerance and caring for Indonesian pluralism to welcome the life of the society 5.0 era. The direction of civic education and society 5.0 has the same mission of realizing a humanist order of society.
Ensuring a Turning Point with Political Ideology and Cultural Knowledge to Achieve the 2045 Vision
Authors: Abadi Mansurni , Widjaja Nicho Hadi , Ishak Shahrial Bin , Olausson Peter
Published: October 2022

The literature analyzing perspectives on Indonesia's golden years in the 2045 narrative is extensive and optimistic. But achieving 2045 is more challenging amid disruption conditions, especially after a multidimensional crisis because of COVID-19. Cite Sukarno's term about the years of Vivere Pericoloso, an Italian phrase that means life is full of danger, making our future toward 2045 uncertain. But the years of Vivere Pericoloso are also the right moment to perfectly achieve the ideals, principles, goals, efforts, and logic of the Indonesia 2045 vision. Culture and politics are two important components that can make our turning point toward 2045 come true. Our findings are political ideology based on expansive penetration with internalization and consistency using indoctrination method toward "Pancasila" itself via youth’s empowerment with the principle of fair and open involvement in the political sphere, and strengthening political literacy plays a critical role in dealing with tech populism and non-integrity that created de-stabilization and incompetence. Cultural knowledge that is based on a sense of belonging with an intercultural bond strategy is also important. In practice, cultural knowledge encourages us to act with positive impacts on multicultural society amidst the post-truth era through: (1) awareness of cultural worldview, (2) good attitude toward cultural differences, (3) knowledge of different cultural practices and worldviews, including having the skill of cultural sensitivity awareness, and (4) cross-cultural skills communication.
Pembudayaan Nilai-nilai Pancasila dalam Konsep Etika Ruang Digital di Era Post-Pandemi
Authors: Hidayah Yayuk , Simatupang Ernawati , Belladonna Aprillio Poppy
Published: October 2022

Persoalan perkembangan dan kemajuan teknologi menciptakan berbagai analisis dan tafsiran yang bermuara pada kemaslahatan umat manusia. Dalam hal ini karsa umat di hadapkan pada dilema global terlebih tentang warga negara global yang melek digital. Urgensi penulisan ini diharapkan mampu menjadi jawaban dalam menghadapi pengaruh penggunaan teknologi yang berbasis digital yang dihadapkan dengan nilai-nilai luhur Bangsa.  Pembahasan dalam artikel ini menekankan pada beberapa aspek tentang pembudayaan nilai-nilai Pancasila dalam konsep etika ruang digital di era post-pandemi yaitu, pertama perlu penguatan literasi digital yang di sinergikan dengan nilai-nilai Pancasila, sehingga saat masyarakat akan dapat tetap nyaman dalam penggunaan teknologi. Kedua nilai-nilai Pancasila perlu divisualisasikan dalam konsep etika ruang digital di era post-pandemi sehingga Pancasila tetap melekat dalam kehidupan digital dan dunia nyata masyarakat. Ketiga, pembudayaan nilai-nilai Pancasila dalam konsep etika ruang digital di era post-pandemi berorientasi pada kemampuan personal dan intrapersonal komunikasi yang bersifat praktik partisipatif dan bermakna. Artikel ini menyimpulkan bahwa dalam pembudayaan nilai-nilai Pancasila dalam konsep etika ruang digital di era post-pandemi akan berdampak dalam penguatan karakter warga negara yang berlandaskan nilai-nilai luhur Pancasila. Oleh sebab itu, melalui artikel ini, pembudayaan nilai-nilai Pancasila dalam konsep etika ruang digital ialah menjadi pedoman seseorang dalam melakukan interaksi digitalnya sehingga akan memperkuat fungsi Pancasila  sebagai pedoman, sebagai pengatur tingkah laku orang termasuk dalam etika ruang digital di era post-pandemi.
Increasing the Spirit of Defending the Country through Citizenship Education in Higher Education
Authors: Pradana Yudha , Andriyana Andriyana
Published: October 2022

Defending the state is the right as well as the obligation of citizens. Nevertheless, defending the state is often simplified as militaristic, but it can also be done through formal educational means. Civic Education (PKn) is one medium to develop the spirit of defending the state. This article attempts to examine the mapping of the linear values ​​of state defense with Civic Education (PKn) subject in university. This research uses a qualitative approach with literature study and documentation study. The results show that the value of state defense in Civic Education (PKn) is the value of love of the homeland which is learned through the material of national identity and the insight of the archipelago; the values ​​of national and state consciousness which are learned through the obligations and rights of the state and citizens, the constitutional values ​and norms of the 1945 Constitution of the Republic of Indonesia, and the democracy of Indonesia; loyalty to Pancasila as state ideology is learned through the material of Pancasila; and the value of sacrificing for the nation and state are taught through law enforcement materials that are just and national defense and state defense. While learning is designed to actualize the values ​​of state defense through cooperative learning, inquiry, and contextual learning.
Slim-endoscopy-stabilized (SOS)-rendezvous-ERC via EUS-transgastric bile duct access: Utilization for severe pancreatitis with consecutive obstructive jaundice and inaccessible major papilla
Authors:   Department of Visceral Surgery and Medicine, University Clinic of Bern, Inselspital, Bern, Switzerland., Oikonomou Vasileios , Wiest Reiner ,   Department of Visceral Surgery and Medicine, University Clinic of Bern, Inselspital, Bern, Switzerland., Macpherson Andrew ,   Department of Visceral Surgery and Medicine, University Clinic of Bern, Inselspital, Bern, Switzerland., Kapoglou Ioannis ,   Department of Visceral Surgery and Medicine, University Clinic of Bern, Inselspital, Bern, Switzerland.
Published: October 2022

After failed biliary cannulation via standard ERC-approach EUS-based rendezvous-ERC (EUS-RV-ERC) is a valid alternative. One of the challenging factors in this setting is the management of the guidewire. Here we propose a method, where a slim endoscope is used to stabilize the guidewire and optimize wire manipulation in a patient who underwent EUS-RV-ERC via a transgastric approach.
Can gadolinium be used as an alternative to iodinated contrast for CT angiography during the current pandemic-related contrast shortage?
Authors:   Department of Medicine, The Brooklyn Hospital Center, Brooklyn, NY, USA., Devarakonda Pradeep Kumar , Reddy Kishan ,   Department of Medicine, Division of Hematology/Oncology, Brookdale University Hospital Medical Center, Brooklyn, NY, USA, Gotlieb Vladimir K ,   Department of Medicine, Division of Hematology/Oncology, Brookdale University Hospital Medical Center, Brooklyn, NY, USA, Dym R Joshua ,   Department of Radiology, University Hospital, Rutgers New Jersey Medical School, Newark, NJ, USA.
Published: October 2022

The Corona Virus (COVID-19) pandemic has brought profound disruptions to the health care systems globally. One of the serious consequences of the Covid-19 pandemic is a global scarcity of Iodinated Contrast Agents (ICA) due to the recent government-mandated lockdown in Shanghai, China. This halted the production of a water-soluble iodine contrast at a major General Electric factory (of the GE Healthcare subsidiary). Many elective diagnostic tests and procedures are being delayed because of this, which has a huge impact on patient health care. Initially, Gadolinium-based Computed tomography Angiography (GbCTA) was proved as a good alternative diagnostic test, especially in patients for whom MRI with gadolinium contrast is not feasible or CTA with iodinated contrast is contraindicated due to iodine-related issues. But due to the concerns of nephrogenic systemic fibrosis and the cost of gadolinium, this alternative option did not become popular. Currently, the scarcity of iodinated contrast once again highlighted the need of using the gadolinium-based CTA. Advancements in CT technology, availability of new data on more stable gadolinium agents, and methods to reduce the contrast dose showed that Gb-CTA studies are possible.
Embolisation of an enlarging paraumbilical vein aneurysm
Authors:   Department of Radiology, King’s College Hospital, Denmark Hill, London, England., Seager Matthew J , Peddu Praveen ,   Department of Radiology, King’s College Hospital, Denmark Hill, London, England., Kane Pauline ,   Department of Radiology, King’s College Hospital, Denmark Hill, London, England.
Published: October 2022

Whilst recanalised Paraumbilical Veins (PUVs) are common pathways for decompression in patients with portal hypertension, aneurysmal change is rare, with only a handful of previously reported cases. A 47-year-old man with cirrhosis and portal hypertension was found to have an asymptomatic, but rapidly enlarging PV aneurysm. This was successfully treated with embolisation and this is the first time that this has been described.
Use of botulinum toxin type A associated with nonthermal microneedling for treating erythematoustelangiectatic rosacea: A case report
Authors:   Curso de Estetica da Universidade Luterana do Brasil, Canoas, Rio Grande do Sul, Brazil., Dallagnol Soares Andressa , Techera Antunes Flavia Tasmin ,   Programa de Pos Graduacao em Biologia Celular e Molecular Aplicada a Saude da Universidade Luterana do Brasil, Canoas, Rio Grande do Sul, Brazil., Martins Marcia Gerhardt ,   Curso de Estetica da Universidade Luterana do Brasil, Canoas, Rio Grande do Sul, Brazil.
Published: October 2022

Treatments for rosacea control the pathology for a short period, requiring daily maintenance with topical and oral cosmetics. This research aimed to report the result of treatment of microneedling associated with botulinum toxin type A in a 37-years old female affected by erythematoustelangiectatic rosacea. The procedure consisted in applyingbotulinum toxintype A (100 UI diluted in 4 ml of saline, via drug delivery), with the electric nonthermal microneedling device. It was performed in 2 sessions, with an interval of 15 days.
Evaluation of phytochemical constituents and antimicrobial activities of ethyl acetate and butanol fractions of Periploca aphylla Decne
Authors:   Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan., Rashid Umbreen , Rashid Khan Muhammad ,   Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan., Bokhari Jasia ,   Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan., Jan Shumaila ,   Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
Published: October 2022

Introduction: Plants have been utilized for the cure of different diseases since ancient times. Medicinal importance of the plants is due to presence of phytochemicals having specific physiological action on the human body. A wide variety of activities have been found in these phytochemicals which might help in preventing chronic disorders. Periploca aphylla Decne belongs to the family Asclepiadoideae, is traditionally used for the cure of cerebral fever and as stomachic. Objectives: In this study, phytochemical constituents and antimicrobial potentials of ethyl acetate and butanol fractions of crude methanolic extract of P. aphylla were investigated.
Glomerulonephritis secondary to undiagnosed malignancy
Authors:   Assistant Professor of Nephrology, Nephrology Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran., Yaghoubi Fatemeh , Dalil Davood ,   Vice-Chancellor of Research, Student Research Committee, Faculty of Medicine, Shahed University, Tehran, Iran.
Published: October 2022

A 68-year-old man presented to the hospital with lower limb edema and hematuria. Blood test and urine analysis revealed 5 g proteinuria with creatinine rise. According to laboratory findings and patient symptoms, the secondary assessments were performed including complement components C3, C4, and CH50, ANA, Anti-dsDNA, c-ANCA and p-ANCA, that all were negative. Then, the microscopic examination of up to 12 glomeruli showed segmental sclerosis in one of them and segmental mesangial matrix expansion in most of the glomeruli.
Reconstructive challenges in major degloving injuries
Authors:   Plastic Surgery Department, University Hospital North Midlands, NHS Trust, UK., Harris Isabella Stevens
Published: October 2022

This case study highlights the surgical management of a 45 year old male, presenting with a significant degloving injury to the lower limb.
Wandering Gastric Leads: A Rare Complication of a New Treatment Modality of Gastroparesis
Authors:   Department of Internal Medicine, Hemet Global Medical Center, Hemet, California, USA., Choday Prithi , Nakka Sasank ,   Department of Internal Medicine, Hemet Global Medical Center, Hemet, California, USA., Wassel Elias ,   Department of Internal Medicine, Hemet Global Medical Center, Hemet, California, USA.
Published: October 2022

Gastroparesis is a chronic disease characterized by delayed gastric emptying in the absence of mechanical obstruction of the stomach. First-line treatment consists of an antiemetic agent with a pro-motility drug. However, in a 12-year prospective study by Jones et al., they found that symptoms of gastroparesis in diabetic patients often persisted despite adequate glycemic control and optimal medical management. Therefore, the Gastric Electric Stimulator (GES) was made for refractory diabetic gastroparesis, defined by failure of 1 year of medical therapy. [1]. However, despite the benefit of the GES, limited studies are commenting on the potential complications.
Innovative, minimally invasive and cost effective use of Ilizarov fixator in correction of a severe knee flexion deformity: A case report
Authors:   St. Johns Medical College, Bangalore, India., Sajeev Joseph , Charls Anit Catherine ,   St. Johns Medical College, Bangalore, India., Zachariah Kurian ,   St. Johns Medical College, Bangalore, India.
Published: October 2022

Poliomyelitis is an infectious disease caused by the poliovirus, which is a member of the genus Enterovirus, belonging to the Picornaviridae family [1]. Poliomyelitis is transmitted from a patient or a symptom-free carrier through the feco-oral route. The manifestations vary from asymptomatic to the most severe forms of debilitating paralysis. Existence of poliomyelitis in ancient times is documented in the history. There are Egyptian paintings from the period 1403 to 1365 BC that depict children with deformed limbs and walking with sticks [1].
Choroidopathy in systemic lupus erythematosus: Report of two cases with literature review
Authors:   Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing 100034, China., Zhang Xiaohui , Zhao Liang ,   Department of Ophthalmology, Peking University First Hospital, Beijing 100034, China., Ji Lanlan ,   Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing 100034, China., Zhao Juan ,   Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing 100034, China., Zhang Zhuoli ,   Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing 100034, China.
Published: October 2022

The ophthalmic manifestations of Systemic Lupus Erythematosus (SLE) are protean, however, choroidopathy is rare. We present two SLE cases with choroidal involvement as the first manifestation, and relevant literatures are reviewed. Both ophthalmists and rheumatologists should be aware of choroidopathy as a rare manifestation of active SLE. Early recognition and proper treatment are important for good prognosis.
Cutaneous metastasis of juvenile-type granulosa cell tumor
Authors:   Department of Gynecology and Obstetrics, Ningxia People’s Hospital, Yinchuan, China., Han Xuechuan , Yu Yan ,   Department of Gynecology and Obstetrics, Ningxia People’s Hospital, Yinchuan, China., Fan Yang ,   Department of Gynecology and Obstetrics, Ningxia People’s Hospital, Yinchuan, China.
Published: October 2022

Granulosa Cell Tumors (GCT) of ovary is a malignant tumor originating from sex cord stromal cells.
COVID-19’UN POSTMENOPOZAL KADINLARDA UYKU DURUMU ÜZERİNE ETKİSİ
Authors: NACAR Gülçin , TÜRKMEN Sevda , SİNEN Rojda , TAŞHAN Sermin Timur
Published: October 2022

Amaç: Bu araştırma, COVID-19’un postmenopozal kadınlarda uyku durumu üzerine etkisinin incelenmesi amacıyla yapıldı.
Yöntem: Tanımlayıcı ve ilişki arayıcı türde olan araştırma, 183 postmenopozal kadın ile yürütüldü. Veriler, Google Formlar üzerinden oluşturulan online anket yardımı ile sosyal medya platformlarından (facebook, instagram, twitter, WhatsApp vb.) postmenopozal kadınlara iletilerek toplandı. Araştırma verilerinin toplanmasında Kişisel Tanıtım Formu ve Kadın Sağlığı İnisiyatifi Uykusuzluk Ölçeği (KSİUÖ) kullanıldı. Araştırma verilerinin analizinde sayı, yüzde, ortalama, standart sapma, ANOVA testi ve bağımsız gruplarda t testi kullanıldı.
Bulgular: Araştırmada, kadınların yaş ortalamasının 55.81±6.12 ve ortalama menopoz yaşının 47.29±6.45 olduğu saptandı. Kadınların %71.6’ sının eğitim düzeyinin okuryazar/ilkokul olduğu, %85.8’inin evli olduğu, %54.6’sının gelirinin giderine eşit/fazla olduğu, %84.2’sinin ev hanımı olduğu saptandı. Araştırmada kadınların %41’inin COVID-19 geçirdiği bulundu. COVID-19 geçiren kadınların KSİUÖ puan ortalaması 13.52±4.79 iken, geçirmeyen kadınların 10.97±4.59’dur (p<0.001).
Sonuç: Araştırmada postmenopozal kadınlarında COVID-19 geçirmenin uyku durumunu olumsuz etkilediği saptandı. Sağlık profesyonellerinin COVID-19 geçiren postmenopazal kadınların uyku problemlerini değerlendirmeleri ve uygun tedavi seçeneklerine yönlendirmeleri önerilmektedir.
Thermoacoustic instability: acoustic, flame and flow interactions
Authors: Morgans Aimee S.
Published: October 2022

Thermoacoustic instability is caused by interactions between acoustic waves, flames and flow. It leads to damaging oscillations in the combustors of aero-engines, rocket engines, gas turbines and boilers. Carbon-free fuels like hydrogen and ammonia show increased propensity to thermoacoustic instability, and the design of futuristic aerospace engines is dependent on being able to avoid it. Because of the range of length scales involved - from the tiny flame front wrinkling to the long acoustic wavelengths - computational prediction is a real challenge. This talk will explore the acoustic, flame and flow interactions which underpin thermoacoustic instability. We will consider the response of the flame to acoustic waves, the damping of acoustic waves at area expansions with flow separation, and the importance of “entropy noise” - the noise generated when temperature fluctuations undergo a flow acceleration. The implications for efficient computational prediction will be discussed.
Mechanisms and Universality in the Subcritical Route to Turbulence
Authors: Barkley Dwight
Published: October 2022

Recent years have witnessed a profound change in our understanding of the route to turbulence in wall-bounded shear flows. In start contract to the classical Hopf-Landau picture where turbulence arises through an increase in the temporal complexity of fluid motion, the route to turbulence in subcritical shear flows occurs via spatio-temporal intermittency and falls in the class of non-equilibrium statistical phase transitions known as directed percolation. In this talk, Dwight Barkley focuses on two aspects of the transition problem. The first is physical mechanisms underlying spatio-temporal intermittency in shear flows. The second is the universality in the subcritical route to turbulence.
A Homokhátság településeinek tipizálása a rendszerváltás után
Authors: Szombathelyi Sándor
Published: October 2022

A Duna–Tisza közi Homokhátság településeinek problémáit, kitörési pontjait Csatári Bálint és kollégái többször is vizsgálták. A klasszikus értelemben nem besorolható vidéki terület nagy bajban van, hiszen az elsivatagosodás fenyegetése mellett az újkori globalizáció hatásainak is ellent kell(ene) állnia, meg kell(ene) őriznie egyediségét, szépségét. Ehhez viszont olyan felmérésekre és vizsgálatokra van szükség, amelyek a döntéshozók számára megfelelő segítséget és alapot biztosítanak ahhoz, hogy olyan pénzügyi háttérrel megerősített cselekvési programot készítsenek, amely a Homokhátság adottságaira és a vidékgazdaságok erőforrásaira támaszkodva képes megalapozni a fenntartható vidékfejlesztést. A települések kategorizálásának problematikája, annak mikéntje régóta meglévő, ismert probléma, melyre egyfajta választ adhat az SPSS programban végzett faktor- és klaszteranalízis. A kategorizálás abban nyújt segítséget, hogy a vidékgazdaságok fejlesztési programjai a helyi adottságokra támaszkodhatnak, egymással összehasonlíthatók lesznek, és eredményeik kiértékelhetőkké válnak.
A mezőgazdasági szén-dioxid-kibocsátást befolyásoló legfőbb tényezők vizsgálata
Authors: Gyarmati Gábor
Published: October 2022

A 21. századi mezőgazdaságban a fenntarthatóság világszerte kiemelt jelentőséggel bír, ezért kezeli többek között az EU is prioritásként ezt a kérdést. A szakirodalmi adatok alapján a mezőgazdaság felelős a Co2-kibocsátás egy – ha nem is túl nagy szeletéért. A klímaváltozásért elsősorban az üvegházhatású gázok tehetők felelőssé, amelyek közül a szén-dioxid mennyisége a legjelentősebb. A mezőgazdaság Co2-kibocsátása (ami a teljes Co2-kibocsátás 7,7-13,8%-át teszi ki) és a mezőgazdaság által kibocsátott összes üvegházhatású gáz együttes mennyisége (ami a teljes kibocsátás 14-18,4%-át adja) nagyon hasonló módon változott világviszonylatban a vizsgált időszakban, vagyis 1990 és 2016 között. Mind az állati eredetű termékek előállítása, mind a műtrágya használata növeli a Co2-kibocsátást. A jelen vizsgálat legfőbb célja annak megállapítása volt, hogy milyen tényezők határozzák meg a mezőgazdasági termelés Co2-kibocsátását – hiszen a mezőgazdaság Co2-kibocsátására ható tényezők feltárásával lehetőség nyílik lépéseket tenni a fenntarthatóság növelése érdekében. A kutatás a rendelkezésre álló világbanki és egyéb adatbázisokat felhasználva, több évtized adatait áttekintve vizsgálta országonként és országcsoportonként ezen tényezőket és az egyes tényezők kapcsolatát. A statisztikai módszerekkel feltárt összefüggések segítséget nyújtanak a szakembereknek, illetve a döntéshozóknak abban, hogy megtalálják azokat a beavatkozási lehetőségeket, melyekkel pozitívan befolyásolhatják a klímaváltozás megfékezését elősegítő folyamatokat. A megművelt területek optimális, kevesebb Co2-kibocsátással járó használata mindenképpen javasolt. Az állattenyésztés korlátozása és a kapcsolódó melléktermékek mennyiségének mérséklése szintén csökkenti a káros gázok kibocsátását, ezenkívül érdemes a trágyahasználatot is optimalizálni, megszüntetve az ideálisnál nagyobb mennyiségek felhasználását.
Kelet-közép-európai növénytermesztő gazdaságok hatékonyságvizsgálata
Authors: Lakatos Vilmos , Makai Szabolcs
Published: October 2022

A visegrádi országok különböző gazdasági aspektusokban történő összehasonlítása sok évre nyúlik vissza. Tanulmányunkban egyes közép- és kelet-európai országok mezőgazdasági és ezen belül a szántóföldi termelés jellemzői kerültek vizsgálataink körébe. A benchmarking jellegű vizsgálatok eredményei segítenek különböző rangsorok felállításában, ezáltal további lehetőségeket adnak ahhoz, hogy amennyiben egy ország adott területen fejlett, azt még tovább fejlessze, ezáltal a régióban vezető szerepet töltsön be. A vizsgálatok eredményei továbbá hozzájárulnak ahhoz is, hogy ha egy ország adott gazdasági mutatói esetlegesen átlagérték alattiak, akkor azok erősítésére, javítására helyezzenek nagyobb hangsúlyt. A mezőgazdaság és ezen belül a szántóföldi növénytermesztés az elmúlt évtizedekben folyamatos technikai és technológiai fejlődésen ment keresztül, amely – természetesen más tényezőktől is függően – segítette az ágazat hatékonyságának növekedését. A termelési szerkezet, az emberi erőforrás, az eszközállomány, a tőkejavak mind-mind összefüggnek a kibocsátással, az eredménytermeléssel, amely összefüggéseket esetünkben leíró statisztikai módszerekkel igyekeztünk feltárni. Eredményeink a kilencéves idősoros adatok alapján rámutattak az emberi erőforrás, valamint az eszközellátottság különbségeire a növénytermesztő gazdaságoknál az országok között. Az elemzés során az eltérő output-input tényezők kombinációival a mezőgazdasági tevékenység hatékonyságát is értékelni tudtuk. Az eredményekre ugyanúgy hatással voltak az egyes országok rendszerváltást követő agrárgazdaság-politikai intézkedései, mint az azt megelőző termelési tradíció és az elmúlt három évtized piacorientált viszonyai is. Vizsgálataink során megállapítottuk, hogy a nagyobb átlagos üzemi méretű cseh és szlovák gazdaságok teljesítmény- és hatékonyságmutatói a legtöbb esetben kedvezőbb értéket képviselnek a többi vizsgált országhoz képest. A lengyel és a román gazdaságok élőmunka-ráfordításának hatékonysága elmarad a többi országhoz képest, de ezen mutató alakulása mindegyik ország esetén növekvő tendenciájú. Az eszközellátottság gazdaságokra vetített értéke szintén növekszik minden vizsgált országban.
Fedezeti pont alkalmazási lehetőségei a tejtermelésben
Authors: Borbély Csaba , Pupos Cintia , Szabari Miklós
Published: October 2022

A hazai tejtermelés helyzetét számos tényező negatívan befolyásolja: magas az eszközigénye, fokozott a munkaerő-szükséglete, a klímaváltozásból eredő szélsőséges időjárás, a piaci helyzet instabil, és napjainkban – más állattenyésztési ágazatokhoz hasonlóan – az elszabadult takarmányárak okoznak komoly gondot a termelőknek. Ebben a helyzetben minden olyan hiteles eszköz, amely elemző, döntéstámogató szerepet tölt be, komoly segítséget jelenthet a gyakorlati szakemberek számára. A munkánk első részeként ezért egy termelésszimulációs modellt hoztunk létre, amely a két ellés közötti időszak (laktáció és szárazonállási időszak) termelési, költség- és jövedelemhelyzetét elemzi takarmányozási napokra lebontva, egy rögzített szempontrendszer alapján kiválasztott mintalaktáción keresztül. A modellel számos szcenárió elemezhető, ebben az anyagban a fedezeti pont tejtermelésben való alkalmazhatóságát vizsgáltuk. A munkát nehezítette, hogy a gyakorlatból átvett laktációk mindegyike hektikus lefutást mutat, így nehéz meghatározni egy pontot, ahol a nyereséges termelés veszteségessé változik. Az elemzésben többféle megközelítést alkalmaztunk, amelyeket részletesen bemutatunk. A fedezeti pont gyakorlatban való alkalmazásának alapja, hogy a tejelő szarvasmarha az egyetlen gazdasági állatfaj, amely esetében az üzemvezetési döntések meghozatalakor nagyüzemi körülmények között is lehet naprakész, egyedi termelési adatokat használni.
Uganda agrárkereskedelmi versenyképességének vizsgálata, különös tekintettel a kávékereskedelemre
Authors: Maróty Mariann Mimi
Published: October 2022

Uganda földrajzi elhelyezkedése, kiemelkedő természeti adottságai és természeti erőforrásai révén alapvetően agrárországnak tekinthető. A gazdaságában és a nemzetközi kereskedelmében óriási szerepet játszik az agrárkereskedelem. Uganda a világ egyik legnagyobb kávétermelő és -exportáló országa. A tanulmány az ugandai mezőgazdaság külkereskedelmi versenyképességének vizsgálatával foglalkozik. Bemutatja a kelet-afrikai ország agrárgazdaságát és a még kiaknázatlan agrárkereskedelmének helyzetét, illetve lehetőségeit. Emellett Uganda agrárkereskedelmének legfőbb partnerországait, valamint a kávéfélék termékcsoportjának külkereskedelmi versenyképességét is vizsgálja Balassa-féle komparatívelőny-mutatók segítségével az 1994 és 2017 közötti időszakban. Továbbá a kereskedelem gravitációs modellje segítségével bemutatjuk, milyen főbb tényezők ösztönzik az ugandai kétoldalú agrárkereskedelmet. Az eredmények alapján megállapítható, hogy Uganda főbb exportpartnerei közül Kenya és Szudán áll az első helyen, míg a legfontosabb exporttermékcsoportok között a kávéfélék és a halfélék töltenek be jelentős szerepet. A Balassa-féle komparatívelőny-mutatók megmutatják, hogy hét kávé, tea, matétea és fűszerek főcsoportjába tartozó termék rendelkezett komparatív előnnyel. A gravitációs modell segítségével a tanulmányból kiderül, hogy az ugandai agrártermékek főként a földrajzilag közeli, hasonló hivatalos nyelvet beszélő, rendszerint magas GDP-vel rendelkező országokba kerülnek exportálásra.
The Relationship Between Perceived Factors Related to Consumers’ Purchase Intention Towards Online Food Delivery
Authors: Chung Jee Fenn , Al-Khaled Akram Abdulraqeb Sultan , Qushairi Qusyanti Binti Mohamad
Published: October 2022

In Malaysia's food and beverage (F&B) industry, online food delivery (OFD) services are a growing trend. With various food distribution firms providing OFD services in Malaysia, online food ordering has become the new eating out. With the recent pandemic outbreak of COVID-19, consumers’ are demanding to have food delivered in accordance with the government directives. Despite the importance of OFD services in Malaysia, research on the purchase intention is limited. Hence, this research study aims to examine the relationship between perceived factors related to consumers’ purchase intention towards OFD services in the context of COVID-19 Pandemic in Klang Valley, Malaysia. Data collection was conducted by using quantitative, non-probability of purposive sampling with screening questions. A total of 428 of samples were collected from the Klang Valley areas through online questionnaires. From this research study, four major factors that lead to consumers’ purchase intention which include perceived usefulness, perceived ease of use, perceived value, and perceived safety. The findings are targeted to redound to the benefit of society considering that OFD services are in greater demand especially during the COVID-19 pandemic which justifies the need for more reliable and life-changing approaches in order to better understand the purchase intention among consumers.