bluuebunny/crossref_metadata_2025 huggingface dataset:
Predictive Model and Feature Importance for Early Detection of Type II Diabetes Mellitus
Authors: Adua Eric , Kolog Emmanuel Awuni , Afrifa-Yamoah Ebenezer , Amankwah Bright , Obirikorang Christian , Anto Enoch Odame , Acheampong Emmanuel , Wang Wei , Tetteh Antonia Yarney
Published: January 2021

Background

Accurate prediction and early recognition of type II diabetes (T2DM) will lead to timely and meaningful interventions, while preventing T2DM associated complications. In this context, machine learning (ML) is promising, as it can transform vast amount of T2DM data into clinically relevant information. This study compares multiple ML techniques for predictive modelling based on different T2DM associated variables in an African population, Ghana.
Methods

The study involves 219 T2DM patients and 219 healthy individuals who were recruited from the hospital and the local community, respectively. Anthropometric and biochemical information including glycated haemoglobin (HbA1c), body mass index (BMI), blood pressure, fasting blood sugar (FBS), serum lipids [(total cholesterol (TC), triglycerides (TG), high and low-density lipoprotein cholesterol (HDL-c and LDL-c)] were collected. From this data, four ML classification algorithms including Naïve-Bayes (NB), K-Nearest Neighbor (KNN), Support Vector Machines (SVM) and Decision Tree (DT) were used to predict T2DM. Precision, Recall, F1-Scores, Receiver Operating Characteristics (ROC) scores and the confusion matrix were computed to determine the performance of the various algorithms while the importance of the feature attributes was determined by recursive feature elimination technique.
Results

All the classifiers performed beyond the acceptable threshold of 70% for the Precision, Recall, F-score and Accuracy. After building the predictive model, 82% of diabetic test data was detected by the NB classifier, of which 93% were accurately predicted. The SVM classifier was the second-best performing classifier which yielded an overall accuracy of 84%. The non-T2DM test data yielded an accurate prediction score of 75% from the 98% of the proportion of the non-T2DM test data. KNN and DT yielded accuracies of 83% and 81%, respectively. NB has the best performance (AUC = 0.87) followed by SVM (AUC = 0.84), KNN (AUC = 0.85) and DT (AUC = 0.81). The best three feature attributes, in order of importance, are HbA1c, TC and BMI whereas the least three importance of the features are Age, HDL-c and LDL-c.
Conclusion

Based on the predictive performance and high accuracy, the study has shown the potential of ML as a robust forecasting tool for T2DM. Our results can be a benchmark for guiding policy decisions in T2DM surveillance in resource and medical expertise limited countries such as Ghana.
Case report: narcolepsy type 2 due to the optic nerve infection of Herpes zoster virus
Authors: Yu Zhenghe , Han Li , Ren Lishan , Xu You , Liu Wenjuan , Ma Lisha , Wei Youdan , WANG Shengdong
Published: January 2021

Rationale: Despite the acknowledged importance of environmental risk factors in the etiology of narcolepsy, there is little research on this topic. The optic nerve infection of Herpes zoster virus as a trigger for narcolepsy has not been investigated.Patient concerns: A 63-year-old male carpenter complained of excessive daytime sleepiness (EDS) over the past 3 years.Interventions: Treated with duloxetine hydrochloride enteric dissolution capsule (Cymbalta) 120mg after breakfast and clonazepam tablets 0.5mg before sleep.Outcomes: General examination showed no abnormalities of his heart, lungs, or abdomen. Neurological examination showed no positive sign. The blood routine and biochemical examination were normal. Denied having been vaccinated against the flu or having been infected with the flu virus. He scored 17 on the Pittsburg sleep quality index, 22 on the Epworth sleepiness scale, 40 on the self-rating anxiety scale, and 69 on the self-rating depression scale. The multiple sleep latency test data showed 2 periods of sleep-onset rapid eyes movement period across 4 successive tests; the average sleep latency was 7.9 minutes, and the rapid eyes movement latency was 1.2 minutes. Treated with duloxetine hydrochloride enteric dissolution capsule (Cymbalta) 120mg after breakfast and clonazepam tablets 0.5mg before sleep, the patient’s EDS symptoms disappeared immediately. He scored 6 on the Epworth sleepiness scale. During our follow-up three months later, he remained well with no complications.Diagnosis: We diagnosed the patient with narcolepsy type 2 according to the 3rd Edition of International Classification of Sleep Disorders (ICSD-3).Conclusion: The patient suffered from EDS and was diagnosed with narcolepsy type 2. The narcolepsy type 2 was linked to viral infection of the optic nerve. Optic nerve virus infection may affect the sleep-pondering pathway.
Clinical Results Following Colonic Resection for Ulcerative Colitis in Elderly Individuals ( Elderly-onset Versus Nonelderly Onset)
Authors: Kuwahara Ryuichi , Ikeuchi Hiroki , Bando Toshihiro , Goto Yoshiko , Horio Yuki , Minagawa Tomohiro , Uchino Motoi
Published: January 2021

BackgroundThe incidence of ulcerative colitis (UC) is increasing, but there are few reports comparing elderly UC patients undergoing colectomy for elderly-onset UC (EOUC) and nonelderly-onset UC (NEOUC). The aim of this study was to analyze the differences between EOUC and NEOUC patients who underwent UC-related surgery.MethodsWe identified 1973 patients with UC who underwent colectomy at Hyogo College of Medicine between January 1, 1984, and December 31, 2018. Only patients aged 65 years old and older who underwent colectomy were enrolled in this study (n=221, 11.2%), and their clinical records were retrospectively reviewed. Patients were divided into two groups according to their age at disease onset: those with onset at younger than 60 years old (NEOUC) and at 60 years old or older (EOUC).ResultsIn the 221 UC patients who underwent colectomy at 65 years old or older, there were 155 cases of EOUC and 66 cases of NEOUC. The main surgical indication in NEOUC patients was colitis-associated cancer/dysplasia (32/66, 47%). In contrast, refractory to medical treatment was the leading cause of surgery in EOUC patients (80/155, 52%). The distributions of surgical indications were different between the two groups (p<0.01).The preoperative daily dose of steroids was significantly higher in the EOUC group than in the NEOUC group (0 mg vs 10 mg, p<0.01). The rates of immunosuppressant, infliximab (IFX) and adalimumab use did not differ significantly between the groups. Significantly more patients underwent emergency surgery in the EOUC group than in the NEOUC group (14% vs 35%, p<0.01).The proportions of patients with postoperative morbidity (Clavien-Dindo grade III or higher) were 17.4% (27/155) in the EOUC group and 13.6% (9/66) in the NEOUC group. There was no significant difference between the two groups (p=0.48). The prognosis of the EOUC patients who underwent UC-related emergency surgery was worse than that of the NEOUC patients (p<0.01). In the EOUC group, 8 (14.8 %) of 54 patients died within 30 postoperative days, while there were no deaths in the NEOUC group.Conclusion Among elderly UC patients undergoing UC-related surgery, EOUC patients undergoing emergency surgery had very poor outcomes, and the mortality rate was 14.8%. In such cases, it is important for physicians and surgeons to begin communication at an early stage so that the optimal surgical timeframe is not missed.
Effects of Irrigation Fluid Temperature During Flexible Ureteroscopic Holmium Laser Lithotripsy on Postoperative Fever and Shivering: A Randomized Controlled Trial
Authors: He Yue , Feng Yougang , He Jun , Liang Bo , Jiang Mindong , Liu Jun , Kang Yongming , Ma Liping , Zhang Qin , Peng Qijia , Yang Tao , Liu Yao , Luo Li , Zhang Min
Published: January 2021

Background. Flexible ureteroscopic holmium laser lithotripsy is used to treat urinary tract calculi, but postoperative complications include shivering, fever and infection. To investigate the effects of irrigation fluid temperature on postoperative complications. Methods. This randomized controlled trial included 120 consecutive patients undergoing flexible ureteroscopic holmium laser lithotripsy at the Urology Department, Suining Central Hospital, Sichuan, China between January 2017 and July 2019. Patients were randomized 1:1:1 into three groups (17°C, 27°C or 37°C). Primary outcome was fever incidence (body temperature >37.5°C) within 48 hours after surgery. Secondary outcomes included shivering incidence during recovery from anesthesia, white blood cell count (WBC), serum procalcitonin (PCT) and incidence of suspected infection (temperature >38.5°C and PCT >0.5 µg/L). Results. There were 108 patients, (17°C group, n=36; 27°C group, n=35; 37°C group, n=37), received flexible ureteroscopic holmium laser lithotripsy and analyzed. Age, gender distribution, body mass index, ASA grade, stone burden, preoperative creatinine, preoperative core temperature and irrigation fluid volume did not differ significantly between groups. 17°C, 27°C and 37°C groups exhibited significant differences in the incidences of postoperative fever (38.9% vs. 17.1% vs. 13.5%) and shivering (22.2% vs. 5.7% vs. 2.7%) (p<0.05 for all pairwise comparisons). There was no significant difference of WBC, PCT and incidence of suspected infection in 37°C or 27°C group compared with 17°C group. One case each of flash pulmonary edema and bleeding occurred in 37°C group. Conclusion. Warming the irrigation fluid can reduce the incidence of postoperative fever and shivering, but further studies are needed to determine the optimal temperature.
The Effect of Intraoperative Neuromonitoring on Damage to the Laryngeal Nerves in Patients Undergoing Total Thyroidectomy.
Authors: Bryk Piotr , Głuszek Stanisław
Published: January 2021

Background: Assessment of intraoperative neuromonitoring in the prevention of damage to the recurrent laryngeal nerve during total thyroidectomy.Material and methods: A group of 367 patients qualified for the study, including 312 women (85.01%) and 55 (14.99%) men, aged 18-79, having undergone total thyroidectomy due to a neutral nodular goiter. The patients were operated on by one surgeon. The study group consisted of 205 patients, including 173 (84.39%) women and 32 (15.61%) men, aged 19-79, who were operated on with the use of intraoperative neuromonitoring. The control group consisted of 162 patients, including 139 (85.80%) women and 23 (14.20%) men, aged 18-77 years, who had undergone surgery only with macroscopic visualization of the recurrent laryngeal nerve without the application of intraoperative neuromonitoring. Then, in the period from 2 to 10 years after the surgery, follow-up examinations were performed, which included 153 patients from the control group (74.6% [153/205]) and 122 patients from the study group (75.3% [122 / 162] Results: The frequency of vocal fold palsy did not differ significantly statistically in the study group and the control group (study group: 4.9% [10/205], control group: 4.9% [8/162]; p = 0.979). In the follow-up study, the incidence of laryngeal fold palsy did not show statistically significant differences between the study and control groups. Most of the damage to the recurrent laryngeal nerves was persistent.Conclusions: Neuromonitoring did not reduce the number of recurrent laryngeal nerve injuries in relation to the nerve visualization alone in noncapsular total thyroidectomy for benign nodular goiter, performed by the same experienced surgeon.
Surface Environment of Phobos and Phobos Simulant UTPS
Authors: Miyamoto Hideaki , Niihara Takafumi , Wada Koji , Ogawa Kazunori , Senshu Hiroki , Michel Patrick , Kikuchi Hiroshi , Hemmi Ryodo , Nakamura Tomoki , Nakamura Akiko M , Hirata Naoyuki , Sasaki Sho , Asphaug Erik , Britt Dan T. , Abell Paul A. , Ballouz Ronald-Louis , Barnouin Olivier S. , Barsei Nicola , Barucci Maria A. , Biele Jens , Grott Matthias , Hino Hideitsu , Hong Peng K. , Imada Takane , Kameda Shingo , Kobayashi Makito , Libourel Guy , Mogi Katsuro , Murdoch Naomi , Nishio Yuki , Okamoto Shogo , Ota Yuichiro , Otsuki Masatsugu , Otto Katharina A. , Sakaani Naoya , Shimizu Yuta , Takemura Tomohiro , Terada Naoki , Tsukamoto Masafumi , Usui Tomohiro , Willner Konrad
Published: January 2021

The Martian Moons eXploration (MMX) mission will study the Martian moons Phobos and Deimos, Mars, and their environments. The mission scenario includes both landing on the surface of Phobos to collect samples and deploying a small rover for in-situ observations. Engineering safeties and scientific planning for these operations require appropriate evaluations of the surface environment of Phobos. Thus, the mission team organized the Landing Operation Working Team (LOWT) and Surface Science and Geology Sub-Science Team (SSG-SST), whose view of the Phobos environment is summarized in this paper. While orbital and large-scale characteristics of Phobos are relatively well known, characteristics of the surface regolith, including the particle size-distributions, the packing density, and the mechanical properties, are difficult to constrain. Therefore, we developed several types of simulated soil materials (simulant), such as UTPS-TB (University of Tokyo Phobos Simulant, Tagish-lake based), UTPS-IB (Impact-hypothesis based), and UTPS-S (Simpler version) for engineering and scientific evaluation experiments.
Distribution of sources of household air pollution: a cross-sectional study in Cameroon
Authors: Baame Esong Miranda , Goura André Pascal , Mbatchou Bertrand Hugo Ngahane , Walage Berenice , Simo Herman Styve Yomi , Medjou Romarique Mboumo , Sonkoue Martial Pianta , Djouda Cyrielle Douanla , Ngnewa Rose Suzie Fowoh , Guiagain Milaine Sandra Teugueu , Agokeng Brice-Donald Kemnang , Homla Olivia Tania Megaptche , Pope Dan , Ateudjieu Jerome
Published: January 2021

Background: Household air pollution (HAP) is a recognised risk factor for many diseases, including respiratory diseases, cardiovascular/circulatory disorders, adverse pregnancy outcomes and cataracts. Population exposure to biomass fuels, including wood, varies among countries and from one fuel source to the other. This study aimed to investigate the different sources of HAP in peri-urban and rural communities in Cameroon. Methods: A cross-sectional survey was conducted in a representative sample of households from the Dschang Health District (DHD) region. This included 848 homes in which a range of fuels for cooking including biomass (firewood, charcoal, sawdust), kerosene and liquefied petroleum gas (LPG) were used both indoors and outdoors. Results: Of the study households, 651 (77%) reported exclusive use of firewood and 141 (17%) reported using more than one source of fuel. Exclusive use of firewood was greater in rural communities (94%) than in peri-urban communities (38%). In peri-urban communites, use of multiple fuels including LPG, wood, sawdust and kerosene, was more common (44.75%). A total of 25.03% of households in both peri-urban and rural communities reported using bottled gas (or liquified petroleum gas (LPG) for cooking. Motivations for choice of fuel included, price, availability (easy access), rapidity, tradition or culture related factorsConclusion: Wood is the main cooking fuel in both peri-urban and rural communities in the Dschang Health District. Work to help households (especially those who are resource poor) to adopt LPG equipment for cooking, and use in a more exclusive way is required.
The Role of Patient Education in Total Knee Arthroplasty: a new methodology for developing countries: a randomized controlled trial
Authors: Andrade Marco Antonio Percope de , Silva Guilherme Moreira Abreu e , Campos Tulio Vinicius Oliveira , Barbosa David Guen Kasuya , Leite Danilo Silva , Rezende Marcus Vinicius Teodoro , Magalhães Tauam Filipe Galo , Santos Felipe Maciel
Published: January 2021

Background: The illiteracy index is high in public hospitals of developing countries,. We established a method in which patients are instructed before total knee arthroplasty (TKA) in a differentiated way without the necessity of reading any self-orientation. Methods: We developed a multidisciplinary approach to improve patient education in TKA comprising of a differentiated orientation conducted by an orthopedic surgeon, a nurse and a physiotherapist. It consists of standardized lectures regarding on pre, intra and post-operative issues in a randomized controlled trial of 79 consecutive patients undergoing primary TKA. Thirty-four patients received the standard education (control group) and 45 patients received the differentiated education (intervention group). The patients were evaluated during at least six months. Results: After a 6-month follow-up period, the Short Form Health Survey (SF-36), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the visual analogue pain scale (VAS) and knee range-of-motion (ROM) improved significantly in both groups. Range-of-motion was better in the intervention group (mean and SD - 106.9 ± 5.7 versus 92.5 ± 12.1 degrees, p = 0.02). Moreover, walk ability (more than 400 meters) was better in the intervention group compared with the control group (97.4% versus 72.4%, p = 0.003). In the intervention and control groups, respectively, 10.5% and 31% of patients reported the need for some walking devices (p = 0.03). Conclusions: A differentiated educational program with a multidisciplinary team had a positive impact on functional outcomes, improving ROM and walk ability of patients undergoing TKA in a short-term evaluation.
Fargesin ameliorates osteoarthritis via macrophage reprogramming by downregulating MAPK and NF-κB pathways
Authors: Lu Jiansen , Zhang Hongbo , Pan Jianying , Hu Zhiqiang , Liu Liangliang , Liu Yanli , Yu Xiao , Bai Xiaochun , Cai Daozhang , Zhang Haiyan
Published: January 2021

Background: To investigate the role and regulatory mechanisms of fargesin, one of the main components of Magnolia fargesii, in macrophage reprogramming and crosstalk across cartilage and synovium during osteoarthritis (OA) development.Methods: 10-week-old male C57BL/6 mice were randomized assigned to vehicle, collagenase-induced OA (CIOA) or CIOA with intra-articular fargesin treatment groups. Articular cartilage degeneration was evaluated using the Osteoarthritis Research Society International (OARSI) score. Immunostaining and western blot analyses were conducted to detect relative protein. Raw264.7 cells were treated with LPS or IL-4 to investigate the role of polarized macrophages. ADTC5 cells were treated with IL-1β and the cultured medium is collected to investigate the crosstalk between chondrocytes and macrophages.Results: Fargesin attenuated articular cartilage degeneration and synovitis, resulting in substantially lower Osteoarthritis Research Society International (OARSI) and synovitis scores. In particular, significantly increased M2 polarization and decreased M1 polarization in synovial macrophages were found in fargesin-treated CIOA mice compared to controls. This was accompanied by down-regulation of IL-6 and IL-1β and upregulation of IL-10 in serum. Although conditioned medium (CM) from the M1 macrophage treated with fargesin reduced the expression of matrix metalloproteinase-13, RUNX2, type X collagen and increased Col2a1 and SOX9 in OA chondrocytes, but fargesin alone could not affect chondrocyte catabolic processes. Moreover, fargesin exerted protective effects by suppressing p38/ERK MAPK and p65/NF-κB signaling. Conclusions: This study showed that fargesin switched the polarized phenotypes of macrophages from M1 to M2 subtypes and prevented cartilage degeneration partially by down-regulating p38/ERK MAPK and p65/NF-κB signaling. Targeting macrophage reprogramming or blocking the crosstalk between macrophages and chondrocytes in early OA may be an effective preventive strategy.
Designing health headquarter workers general competency model for the national level: A multiple qualitative study
Authors: Fattahi Hamed , Gorji Hasan Abolghasem , Bayat Mahboubeh , Fattahi Arash , Seproo Faezeh Ghasemi
Published: January 2021

BackgroundAn effective health headquarter worker has behaviors, knowledge, skills, and motivations which are behavioral, technical, and motivational prerequisites for successful performance in a job. This study aims to identify the general competencies of health headquarters workers to meet the needs of the health system.MethodsWe used multiple qualitative methods to facilitate a consensus-building process on developing core competencies. First, we used systematic review and meta-synthesis to identify the dimensions and components of core competencies. Using a critical case sampling, we interviewed twenty-six participants and analyzed the information with thematic content analysis. In the third phase, we divided the health headquarters workers into three levels. Then, to present the initial model of competencies, the Mini Delphi method was used. Finally, in the fourth phase, to reach a consensus on the importance of each competency and determine the level of competencies required for each level of health headquarters workers, three-step Delphi method was used, and we presented the final model.ResultsWe presented a competency model for three levels of health headquarters workers. The main competencies are (1) leadership and management (12 components), (2) analysis, interpretation, and reporting (6 components), (3) interpersonal relationships (4 components), (4) individual competencies (7 components), (5) cultural and community competencies (5 components), (6), and administrative competencies (4 components). All competencies are needed for the third level of health headquarters workers. In general, second and third levels of health headquarters workers need high and middle level of required competencies that mean these workers' levels should have all competencies before using them in top of national health organizations. ConclusionThe competencies were extracted due to the levels of health headquarters workers, as well as the level of competencies required by each group of experts, could act as a guide for policy-makers and managers related to human health resources in the health sector, and help them adopt appropriate strategies to employ and train health headquarters workers.
Health seeking behavior of Japanese retirees in Thailand: a cross-sectional study
Authors: Miyashita Yumiko , Akaleephan Chutima , Vedrasco Liviu
Published: January 2021

Background: Despite widespread cross-border migration of retirees, little is known about their healthcare seeking behavior in a destination country. This study explores factors related to the use of health services in Thailand by Japanese long-stay retirees.Methods: A survey of Japanese long-stay retirees aged 50 and older was conducted in cooperation with nine Japanese self-help clubs in Bangkok, Chiang Mai, Chiang Rai, and Phuket. The dependent variable was receiving medical treatment in Thailand in the previous 12 months. People who did not receive treatment in Thailand were divided into two groups; those who had treatment only in Japan and those who did not have treatment anywhere. Independent variables included i) predisposing factors: age, sex, years lived in Thailand, ii) enabling factors: marital status, adjusted annual household income, and iii) need factors: existence of chronic diseases and health related quality of life. Results: Of 226 eligible participants, 106 (47%) received medical treatment in Thailand, 41 (18%) received treatment only in Japan, and 79 (35%) did not receive treatment in any country in the previous 12 months. Multivariate analysis identified that Japanese retirees who stayed in Thailand for less than five years were less likely to receive treatment in Thailand. Retirees who had no chronic diseases and did not return to Japan tended to not receive treatment anywhere while those who were covered by Japan’s national health insurance and stayed in Thailand for shorter periods in the past 12 months were more likely to receive treatment only in Japan. Conclusion: The Thai government’s retirement tourism promotion policy should encourage sharing of transparent medical quality and pricing information by medical facilities to facilitate access among foreign retirees, especially of relative newcomers to reliable medical facilities and promote the trust in Thai medical services. As this study indicates medical cost and health insurance coverage is an important factor of one’s cross-border health seeking behavior, further studies are required to evaluate the impact of the 2017 and 2019 government policy on mandatory health insurance for retirees on their health seeking behaviors.
HISTORICAL EXPERIENCE OF PREVENTING CORRUPTION IN THE ANCIENT
WORLD AND ITS IMPORTANCE FOR ANTI-CORRUPTION ACTIVITY IN UKRAINE
Authors: Zayats B.R.
Published: January 2021

The activities of the militia in 1947 had its own peculiarities. This is, firstly, post-war devastation, which has reached enormous proportions. Secondly, it was the 1946-1947 famine in Ukraine, that had the worst results in the first half of 1947. Thirdly, it a post-war morally-psychological situation in society is a habit to violence and application of weapon. Fourthly, a negative influence on counteraction to criminality was the abolition of death punishment in May in 1947. Fifthly, in 1947 there is the strengthening of the general repressiveness of the totalitarian regime in Ukraine, due to the return to the leadership of L.M.Kahanovych. Sixth, 1947 was the peak of the increase of criminality in the post-war years. Seventh, on December, 14 in 1947 by a government resolution was accepted «About realization of monetary reform and about the abolition of cards on food and industrial stuff». The basic activity of militia, related to this event, came true already in 1948, that is why we examine the beginning of this work only. The review of literature testifies that a scientific problem is given is investigational not enough. The novelty of the article consists in that in her basic work of militia assignments are first studied in this certain historical period - 1947р., a question is complemented about the influence of structural changes in the organization of militia of Ukrainian SSR on counteraction to criminality. There was a reorganized control system of criminal search in these years, increase her basilar links and the number of skilled staff increased. In 1947 from the Ministry of Internal Affairs to the Ministry of State Security were transferred departments to combat banditry. At the offices of the Ministry of Internal Affairs, there were organized special departments to combat speculation. Militiamen of Ukraine in these years in majority honestly carried out the duties. But legality and discipline in a militia remained at an insufficient level. A militia did not succeed to be obtained an improvement of the criminogenic situation - the crime in this year grew. Need a further study activity of militia in relation to counteraction to hooliganism in an indicated period and the work of district militia officers.
Keywords: Ukraine, 1947, militia, Ministry of Internal Affairs, counteraction of criminality
Virtual Reality Support for Dental Treatment Premedication
Authors: Kupka Tomasz
Published: January 2021

The objective is to short review the current state of the art of virtual reality medical application in term of minimal invasive dentistry. An outline of the most important aspects of virtual reality has been created, and a subsequent literature search for articles related was conducted. The current state of the art of virtual reality includes a variety of applications, among others premedication, analgesics, anaesthetics plays an important role in informatics medicine. There is a growing consensus regarding the need to develop knowledge and possible introduce virtual reality as a non-pharmacological support for dental treatment.
Prenatal diagnosis of complete transposition of the great arteries and
dextrocardia in the fetus with left juxtaposition of the atrial appendages
and subpulmonary ventricular septal defect
Authors: I.N. Daminov
Published: January 2021

The case of prenatal ultrasound diagnosis of complete transposition of the great arteries and dextrocardia
in the fetus with left juxtaposition of the atrial appendages and subpulmonary ventricular septal defect in
the third trimester is presented. The postnatal echocardiography confirmed the prenatal diagnosis. At 2 months
of life, first surgical intervention under extracorporeal circulation was performed: the arterial switch operation
and narrowing of the dilated pulmonary artery root, closure of patent foramen ovale, ligation of patent ductus
arteriosus. At the age of 8 months, the child underwent a second operation: closure of ventricular septal defect
with the transventricular approach and plastic surgery of the pulmonary artery. After an operation third-degree
atrioventricular block (bradyarrhythmias) has occurred and 2 weeks later patient's health improvement was
achieved, and he underwent implantation of a single-chamber pacemaker. Currently, the child is 2 years old,
physical and mental development corresponds to age and he remains under the supervision of specialists.
Prenatal diagnosis of epignatus with invasion of the face and neck area
Authors: O.I. Guseva , S.A. Chugunova , N.Y. Polovinkina et all
Published: January 2021

A case of prenatal ultrasound diagnosis of epignathus with sprouting on the face and neck area is presented.
Teratoma in the neck region diagnosed at 20 weeks, epignathus — at 30–31 weeks of gestation. Pregnancy was
complicated by the development of pronounced polyhydramnios. At 31 weeks of gestation premature birth
occurred in the breech presentation of a dead male fetus. The diagnosis was confirmed after birth.
Prenatal ultrasound diagnosis of pulmonary atresia with a ventricular
septal defect and major aortopulmonary collateral arteries (MARCA)
Authors: V.V. Ezhova
Published: January 2021

The case of prenatal diagnosis of pulmonary artery atresia with a ventricular septal defect and major
aortopulmonary collateral arteries at 34 weeks is presented. Atresia of the pulmonary artery with a ventricular
septal defect and major aortopulmonary collateral arteries (type B) was diagnosed. At 39 weeks birth occurred.
After the examination, the prenatal diagnosis was confirmed. The condition of the newborn was rated as
satisfactory. On the 7th day the child was discharged under the supervision of a cardiologist. Surgical treatment
is planned. The article discusses the issues of differential prenatal diagnosis, modern possibilities of operative
treatment and prognosis.
Ultrasound technologies in the prenatal diagnosis of multiplex congenital
arthrogryposis
Authors: N.M. Normuradova , B.B. Majidov
Published: January 2021

А case of prenatal ultrasound diagnosis of congenital multiple arthrogryposis in the 3rd trimester of gestation
is presented. The fixed position in the unfolded form of the knee joints, the deformation of the hands, as well
as polyhydramnios and a small stomach, due to a decrease in swallowing function and contracture of the jaw
joints, were visualized.
Characterization of methicillin-resistant Staphylococcus aureus strains in sewage treatment plants in Tehran, Iran
Authors: Rahimi Fateh , Katouli Mohammad , Pourshafie Mohammad R.
Published: January 2021

Multidrug-resistant Staphylococcus aureus strains have been commonly found in hospitals and communities causing wide ranges of infections among humans and animals. Typing of these strains is a key factor to reveal their clonal dissemination in different regions. We investigated the prevalence and dissemination of different clonal groups of S. aureus with resistance phenotype to multiple antibiotics in two sewage treatment plants (STPs) in Tehran, Iran over four sampling occasions. A total of 576 S. aureus were isolated from the inlet, sludge and outlet. Of these, 80 were identified as methicillin-resistant S. aureus (MRSA) and were further characterized using a combination of Phene Plate (PhP) typing, staphylococcal cassette chromosome mec (SCCmec), ccr types, prophage and antibiotic-resistant profiling. In all, eight common type (CT) and 13 single PhP type were identified in both STPs, with one major CT accounting for 38.8% of the MRSA strains. These strains belonged to three prophage patterns and five prophage types with SCCmec type III being the predominant type. Resistance to 11 out of the 17 antibiotics tested was significantly (P < 0.0059) higher among the MRSA isolates than methicillin-sensitive S. aureus (MSSA) strains. The persistence of the strains in samples collected from the outlet of both STPs was 31.9% for MRSA and 23.1% for MSSA. These data indicated that while the sewage treatment process, in general, is still useful for removing most MRSA populations, some strains with SCCmec type III may have a better ability to survive the STP process.
Application of response surface methodology for uranium(VI) adsorption using hydroxyapatite prepared from eggshells waste material: study of influencing factors and mechanism
Authors: Ouassel Safir , Chegrouche Salah , Nibou Djamel , Melikchi Redouane , Aknoun Abderahmane , Mellah Abdelhamid
Published: January 2021

Hydroxyapatite (HAp) was synthesized from biowaste hen eggshells by wet precipitation method in which calcium hydroxide and phosphoric acid were used as precursors. The effectiveness of uranium(VI) adsorption onto HAp was investigated by batch adsorption experiments from aqueous solutions. The obtained HAp powder was characterized by X-ray diffraction, Fourier transform infrared spectroscopy, Raman spectrometry, point of zero charge and Scanning electron microscope. The factors and levels used during the experiments were pH (2–5), adsorbent mass (0.01–0.05 g), and initial U(VI) concentration (100–310 mg L−1). A Box–Behnken design combined with analysis of variance was used to interpret the main effect influencing the adsorption. The results showed that pH was the most significant parameter affecting U(VI). The kinetic data correlates well with the pseudo-second-order model. The adsorption isotherms fitted the Langmuir-1 type model with the qmax = 175.22 mg g−1 at 25 °C. The calculated value of the mean free energy indicates the chemisorption process. Under optimal conditions, the uranium effluent derived from the precipitation of ammonium uranyl carbonate removal performance of 98% was achieved. This study proved that HAp prepared from eggshell was an ecofriendly and low-cost adsorbent and was very effective for the adsorption of U(VI) from aqueous solutions.
Using of actual author's project technology "Fashion-constructor" for preparing specialists in the direction of "Fashion design"
Authors: Andreeva Varvara Vladimirovna
Published: January 2021

The article deals with the development and use of new educational technologies for the training of fashion designers. The article describes the innovative author's development of training in clothing design. The advantage of this method for motivation and formation of professional competencies is proved. As well as creating a high-quality educational environment directed at developing the creative abilities of students and their motivation to apply the results in practical project activities.
Melacak Pluralisme Agama dalam Film “PEEKAY”
Authors: Purba Veny , Retnasary Maya , Indriyansyah Yoggi
Published: January 2021

Diversity or plurality such as ethnicity, race, culture, and religion become a natural thing in the community, in particular, the diversity of religions must be accepted by society. The existence of religious group differences is a very natural thing, where the group is under their own theological and legal systems. The Peekay film is one of the films that represent the diversity of religions in India, by showing how every religion worships God, and also displays the identities of each religion, such as Hinduism, Islam, Catholic Christianity, Sikhism, and Jainism. Purpose of this research is to know and understand the menaing of plurality in Peekay movie. This study uses qualitative methods, and semiotics studies by using the semiotic theory of the two orders of signification model from Roland Barthes which interpret the signs through the stages of denotation, connotation, and myth, the paradigm used in conducting this research uses the constructivist paradigm. Data collection techniques in research carried out with documents, where researchers look for written sources, both from books, journals, research-relevant research, and the internet media. The results obtained by researchers are displaying several scenes that represent religious plurality, both with visuals and also dialogue and Voice Over contained in the PK film. Such as the scene depicting the buildings of places of worship of each religion, and the way each religion performs worship and Peekay who says that in this world there are many religions and each religion has its own Belief or God, where each of these religions has a way in doing God's commands. The diferents in Hinduism, Islam, Catholic Christianity, Sikhism, and Jainism symbol are the main core in this research.
Gender, Diversity, and Inclusion International Workshop Proceedings
Authors: Habib Sanzida
Published: January 2021

This International Workshop on Gender, Diversity, and Inclusion was an outcome of the collaborative effort by the Department of Gender, Sexuality, and Women’s Studies (GSWS) at Simon Fraser University (SFU) in Canada and the Research Center for Gender and Development of Hohai University (HHU) in Nanjing, China. In 2017, a Memorandum of Understanding (MOU) between the SFU Faculty of Arts and Social Sciences (FASS) and the HHU School of Public Administration was signed by both universities. One of the stated objectives was to organize a collaborative international workshop on gender and diversity at SFU in 2019.
A DFT study of structural and electronic properties of anatase TiO2 phase with Ni and oxygen vacancies impurities
Authors: De la Torre Pari S.A. , Aragón F.F.H. , Villegas-Lelovsky L. , Salazar D.G. Pacheco
Published: January 2021

In the present work, first-principle theory using the functional density theory (DFT) was used in the ABINIT software package using the PBE pseudopotential (norm-conserving pseudopotentials). To determine the structural parameters such as lattice constant, Bulk modules, and energy formation, for the TiO2 anatase phase doped with substitutional and interstitial nickel impurity, oxygen vacancies (VO) are also included in the present work. For this study, the 2x1x1 supercells with 24 atoms and 2x2x1 with 48 atoms were used. Different types of Ni dopants and oxygen vacancies were considered for energy formation using the 2x2x1 supercell. Our results show that the values of network parameters, minimum energy, and Bulk modulus remain constant with the supercell's growth. With the inclusion of Ni in the supercell substituting the Ti-ions, the unit cell volume (V) exhibits a decrease in agreement with ionic radii mismatch between Ti and Ni atoms. However, when entry as an interstitial form a significant increase is shown. The preliminary results of the energy of formation analyzed for the Ni defects show that it is more probable for an interstitial Ni than for a substitutional Ni.
Zn(II) Glycine Complexes: an early analysis through a theoretical DFT approach
Authors: Ferreira Frederico Henrique do Carmo , Hamada Yahia Z , Costa Luiz Antônio Sodré
Published: January 2021

Amino acids are well described in literature and much information is known about them so far. However, considering the free ions present on living organisms it is likely complexations occur; many works have been released discussing the structures of those species. The complexation of Zn(II) ions and glycine (Gly) results in a stable structure formed by hydrogen interactions between the species. In order to study these interactions, this work uses theoretical approaches to evaluate both structural and electronical information.
Molecular Dynamics of graphene bilayer: in water armchair AB 9x4y turbostratic.
Authors: Reis Keli Cristina Barbosa dos , Lima Anderson Barbosa , Faria Roberto Ribeiro , Souza Lourival Rodrigues de , Batista Victor de Sousa , Abrahão Junior Odonírio
Published: January 2021

Graphene forms armchair or zigzag bilayers with AA or AB lined sheets, which differ its properties. This work present a Molecular dynamics study of a graphene bilayer model developed to understand the way of its interactions in aqueous solution, including SDS and LAS surfactants. Structures of 9x and 4y aromatic rings shows a turbostratic stacking with 3,33Å between the sheets. This structure as stable in water and attract the surfactants with sp3 carbon chains, with hydrophobic interactions and carboxylic groups at the edges. It exhibits stable behavior from room temperature to 368K, with a rotational angle of 20Å between the leaves, demonstrating a turbostratic alignment. The adhered surfactants are aligned horizontally, following the movement of the bilayer. They present altered conformational freedom, with the polar portion out of the plane, near to the edges. The reproducibility of experimental intermolecular interactions with hydrophobic portions of the surfactants was also obtained, maintaining a trajectory with turbostratic angulation between the leaves. The predicted molecular behavior of graphene bilayer in aqueous solution contributes to the planning of graphene-based materials.
EFEITOS DE MICRO-HIDRATAÇÃO EM PROPRIEDADES CONFORMACIONAIS E ESPECTROSCÓPICAS DO ANTIBIÓTICO MARBOFLOXACINO
Authors: Queiroz Nayhara B. D. F , Amaral M. S.
Published: January 2021

Marbofloxacin (MRB) is a fluoroquinolone used as a veterinary antibiotic. Some analytical methods of optical absorption are used for their determination in pharmaceutical formulations. Thus, we decided to study the electronic absorption spectrum of MRB in the UV-Vis region. For this, we use the TD-DFT, COSMO methods - based on the solvation continuum model - and micro-hydration. The interactions of MRB in both water and vacuum were simulated using computational modeling techniques. Ab initio quantum calculations were used to optimize the geometry of the isolated molecule and in the optical transition energy calculations. The solute-solvent simulation was performed with the Molecular Dynamics technique in the NpT ensemble using a temperature of 300 K in the Amber computer package. The system balance was monitored by Root Mean Square Deviation. The analyzes of the absorption spectra were carried out using the micro-hydration method. This method involved the use of different numbers, from 2 to 8, of the water molecules of the first solvation layer to calculate transition energies. The transition energies were calculated using the TD-DFT method at the theory level B3LYP / 6-311G using together the Conductor-like Screening Model solvation model that assesses the effect of the solvent implicit in the system. For all micro-hydration systems, energy absorption decreases as the wavelength increases. Observing the values it is noticed that there was a deviation in the absorption spectrum 325.4 nm (in the isolated molecule) to 274.1 (with the addition of water). These values are within the experimental ones where we have the bands with maximum absorption at 268 nm and 335 nm.
Experimental and theoretical study of the solvatochromic effect of the species iodine (I2) and triiodide ion (I3–)
Authors: Silva Denilma Mauricio Cardoso da , Maia Thalita Vaneska Moreira , Silva Andréa Claudia Oliveira , Leal Régis Casimiro
Published: January 2021

Despite the experimental and theoretical agreement, in the inverse relationship between increased polarity and decreased maximum absorption, the high deviations led us to question the possibility of forming other species in solution and therefore motivated the development of this work. This work aims to investigate the effect of the solvent on the species triiodide (I3–), and to compare the previous results obtained for iodine (I2). The effect of the solvent on the species I3– was promising in view of an improvement in the results compared to when using I2 as a solute. Experimentally it is possible that I2 molecules are in equilibrium with I3– molecules.
Solvation of different folding states of ubiquitin by EMIMDCA: a study using minimum distance distribution functions
Authors: Piccoli Vinicius , Martínez Leandro
Published: January 2021

Ionic liquids are versatile solvents that have been used in various applications: as green solvents, catalysts, and in biotechnological systems. The optimization of ionic liquids use can be achieved by an understanding of its behavior in chemical systems. Here, the interaction between EMIMDCA and four different folding states of the ubiquitin is studied by the computation of minimum-distance distribution functions from molecular dynamics. In all systems presented here, EMIMDCA solvates the protein preferentially for all types of structures simulated, indicating a denaturation behavior in the presence of ubiquitin. The affinity of EMIMDCA to the protein conformations, with more residues exposed to the solvent, is related to the interactions of the ions with, manly, the apolar residues. Hence, we will show that as the protein structure becomes more open, the interactions between the ions and the protein start to have more influence from the dispersive interaction than the hydrogen bonds.
Estudo do tautomerismo ceto-enólico da 7-epi-clusianona através de cálculos teóricos de deslocamentos químicos de RMN
Authors: Albuquerque Ana Carolina Ferreira de , Carneiro José Walkimar de Mesquita , Santos Junior Fernando Martins dos
Published: January 2021

The properties of natural products, including their biological and pharmacological activities, are directly correlated with their chemical structures. Thus, a correct structural characterization of these compounds is a crucial step to the understanding of their biological activities. However, despite the recent advances in spectroscopic techniques, structural studies of natural products can be challenging. This way, theoretical calculations of Nuclear Magnetic Resonance (NMR) parameters (such as chemical shifts and coupling constants) have proven to be a powerful and low-cost tool for the aid to experimental techniques traditionally used for the structural characterization of natural products. One of the several applications of quantum-mechanical calculations of NMR parameters is the study of tautomerism. Since chemical shifts are sensitive to the tautomeric equilibrium, this technique can provide crucial informations. In this work, it was applied a protocol for theoretical calculations of ¹³C chemical shifts in order to study the tautomerism of the natural product 7-epi-clusianone, isolated from Rheedia gardneriana. This protocol consists in a Monte Carlo conformational search, followed by geometry optimization and shielding tensors calculations, both using a density functional level of theory. After comparison of theoretical and experimental data, it was possible to confirm the two tautomers present in equilibrium in the experimental solution. Furthermore, this study highlights how this theoretical protocol can be an effective method in identifying the preferred tautomeric form in solution.
Temperature	effects	on	polarons	mobility	in	nonfullerene organic heterojunction
Authors: Armando Hudson Rodrigues , Pereira Júnior Marcelo Lopes , Ribeiro Júnior Luiz Antônio
Published: January 2021

In this work, we studied electronic transport in organic solar cells (OSC) with the aid of the open-source program Excimontec, which uses the kMC algorithm and Marcu's theoretical model to model the transfer rate of charge. The aim of the study was to simulate the effect of temperature variation on the rate of mobility of charge carriers in heterojunctions composed of non-fullerene acceptor units BYG-1/SMD and BYG- 2/SMD together with a small molecule donor (SMD) appropriate.