bluuebunny/crossref_metadata_2025 huggingface dataset:
Pathology and Prognosis of Colonic Adenocarcinomas With Intermediate Primary Tumor Stage Between pT2 and pT3
Authors: Paulsen John D. , Polydorides Alexandros D.
Published: September 2021

Context.—

Primary tumor stage (pT) is an important prognostic indicator in colonic adenocarcinomas; however, cases that have no muscle fibers beyond the advancing tumor edge but also show no extension beyond the apparent outer border of the muscularis propria (termed pT2int) have not been previously studied.

Objective.—

To address the clinicopathologic characteristics and prognosis of pT2int tumors.

Design.—

We recharacterized 168 colon carcinomas and compared pT2int cases to bona fide pT2 and pT3 tumors.

Results.—

In side-by-side analysis, 21 pT2int cases diverged from 29 pT2 tumors only in terms of larger size (P = .03), but they were less likely to show high-grade (P = .03), lymphovascular (P < .001), and extramural venous invasion (P = .04); discontinuous tumor deposits (P = .02); lymph node involvement (P = .001); and advanced stage (P = .001) compared with 118 pT3 tumors. Combining pT2int with pT2 cases (versus pT3) was a better independent predictor of negative lymph nodes in multivariate analysis (P = .04; odds ratio [OR], 3.96; CI, 1.09–14.42) and absent distant metastasis in univariate analysis (P = .04) compared with sorting pT2int with pT3 cases (versus pT2). Proportional hazards regression showed that pT2 and pT2int cases together were associated with better disease-free survival compared with pT3 tumors (P = .04; OR, 3.65; CI, 1.05–12.70). Kaplan-Meier analysis demonstrated that when pT2int were grouped with pT2 tumors, they were significantly less likely to show disease progression compared with pT3 (P = .002; log-rank test) and showed a trend toward better disease-specific survival (P = .06) during a mean patient follow-up of 44.9 months.

Conclusions.—

These data support the conclusion that pT2int carcinomas have clinicopathologic characteristics and are associated with patient outcomes more closely aligned with pT2 rather than pT3 tumors.
SSRP1 affects the growth and apoptosis of gastric cancer cells through AKT pathway
Authors: Jin Guohua , Zhao Ruihong , Zhang Jianguang , Cao Tingting , Tang Tongyu
Published: September 2021

Background: We aimed to determine the SSRP1's potential influence on the apoptosis and proliferation of gastric cancer (GC) cells and its regulatory mechanism. Methods: SSRP1 expression in GC cells and tissues was detected via quantitative reverse transcription-polymerase chain reaction (qRT-PCR). The interrelation between clinicopathological characteristics of GC patients and SSRP1 expression was analysed via x2 test, and the correlation between SSRP1 expression and overall survival rate was analysed using Kaplan-Meier survival analysis. After the knockdown of SSRP1 in AGS cells, the SSRP1 expression, colony formation ability, cell viability, cell cycle changes, apoptosis rate, and migration and invasion ability were detected through qRT-PCR, colony formation assay, CCK8 assay, flow cytometry and transwell test, respectively. Finally, the effects of down-regulation of SSRP1 on the expressions of phosphorylated-protein kinase B (p-AKT), B-cell lymphoma-2 (Bcl-2) and Bcl-2 associated X protein (Bax) were explored using Western blotting. Results: SSRP1 displayed a high expression in GC cells and tissues. SSRP1 expression was closely interrelated to the TNM stage, lymph node metastasis and tumour size. The survival rate of patients was markedly shorter in the high expression group than in the lower expression group. After the knockdown of SSRP1 in cells, the viability and colony formation ability of AGS cells were inhibited. In addition, the cell ratio in the G1 phase was increased, while that in the S phase declined, and the cell invasion and migration were obviously weakened. It was found from Western blotting that the knockdown of SSRP1 could evidently suppress the protein levels of Bcl-2 and p-AKT but promote the protein expression of Bax, indicating that silencing SSRP1 can inhibit the proliferative capacity and increase the number of GC cells through inactivating the AKT signalling pathway. Conclusions: SSRP1 rose up in GC tissues and cells. Reduction of SSRP1 can inhibit the proliferative capacity and increase the number of GC cells through inactivating the AKT signalling pathway.
Actividades cotidianas en redes sociales Estudio del comportamiento habitual y las medidas protección de los usuarios de Facebook, Instagram y Twitter
Authors: Solari-Merlo Mariana N.
Published: September 2021

El creciente uso de las redes sociales conlleva una exposición cada vez mayor de información personal susceptible de ser utilizada para la comisión de diversos delitos. Este nuevo espacio de criminalidad ha sido analizado en diversas ocasiones a la luz de la Teoría de las Actividades Cotidianas y de los estilos de vida, poniendo especial interés en las rutinas habituales de los usuarios de estas plataformas –estilos de vida online- y en las medidas de autoprotección que establecen –guardianes- para evitar convertirse en objetivos adecuados. Sobre la base de estos desarrollos, el presente trabajo analiza el comportamiento habitual de los usuarios de las principales redes sociales –Facebook, Instagram y Twitter- a efectos de determinar su grado de autoexposición, las medidas de autoprotección y las consecuencias negativas experimentadas con su uso.
EL ANÁLISIS GEOGRÁFICO Y CRIMINOLÓGICO DE EVENTOS INCÍVICOS. UN TEST DE LA TEORÍA DE LOS PUNTOS CALIENTES
Authors: ORTIZ GARCÍA JORDI
Published: September 2021

Resumen: El estudio espacio – temporal del evento delictivo ha desempeñado a lo largo de la historia un papel fundamental en el análisis del delito. La aparición de nuevos softwares informáticos más potentes permite mejorar la geolocalización de los escenarios donde se producen los delitos y explicar, entre otras cuestiones, dónde residen los infractores o dónde es más probable ser víctima de un delito. Los estudios llevados a cabo en este sentido muestran que existen zonas donde se concentran un mayor número de delitos o espacios donde pueden ser víctima de un delito con mayor probabilidad que en otros. Este trabajo tiene como objetivo realizar un estudio situacional de las denuncias interpuestas por el incumplimiento de la ordenanza de convivencia de Guadalajara y analiza si los eventos incívicos se concentran de forma desproporcionada en determinadas zonas. La metodología empleada es una metodología cuantitativa a partir del análisis descriptivo de las denuncias interpuestas por la policía local de Guadalajara por conductas prohibidas reguladas en la ordenanza de convivencia entre los años 2008 y 2016 (ambos inclusive). Para llevar a cabo este estudio, se ha utilizado el paquete estadístico SPSS (versión 22) y el software de información geográfica QGis (versión 3.16). Los resultados obtenidos, han evidenciado una mayor concentración de actos incívicos en zonas con un mayor agrupamiento de locales de ocio nocturno y espacios verdes en la ciudad de Guadalajara.
Facilitating Student-Created Math Walks
Authors: Wang Min , Walkington Candace , Dhingra Koshi
Published: September 2021

An example of an after-school club activity gives educators some tools and suggestions to implement such an approach in their schools.
Comparing Probabilities: Rock, Paper, Scissors, and Coin Toss
Authors: Reiser Elana
Published: September 2021

In this activity, students find the theoretical probabilities of winning a coin toss and a round of the rock, paper, scissors game. They next devise strategies to win and test them out. Students then compare the theoretical probabilities they found with the experimental probabilities.
Ensino de cinema
Authors: Barbosa Diogo José de Moraes Lopes
Published: September 2021

Nesta pesquisa, investigamos as possibilidades de ensino do cinema no ambiente escolar, sobretudo, em uma perspectiva do fazer, da experiência da criação por parte dos próprios alunos. Para isto, utilizamos o conceito da pedagogia da criação, termo proposto por Alain Bergala (2008), estudioso do ensino do cinema em escolas. Aplicamos as teorias abordadas em um curso oferecido a estudantes da rede pública no Recife. Ele teve um caráter prático, onde os alunos tiveram a oportunidade de produzir seus próprios filmes. Os resultados obtidos nessa experiência, ao mesmo tempo em que nos mostraram possibilidades interessantes e enriquecedoras, nos alertaram para alguns problemas existentes na implantação de projetos diferenciados no ambiente escolar. Apesar disso, concluímos que é possível e necessário ensinarmos cinema na escola, sobretudo, a partir de uma pedagogia galgada na criação, na experimentação, na realização de projetos audiovisuais por parte dos alunos.
Tradições culturais no ensino de música em classes hospitalares
Authors: Cunha Eudes Oliveira , Cardoso Rita de Cássia Silva , Castro Ângelo Tavares
Published: September 2021

Este trabalho tem o objetivo de descrever práticas de ensino de Música em classes hospitalares, a partir de uma proposta que se baseou em saberes musicais da tradição oral do Nordeste brasileiro. Ao considerar as especificidades da escolarização em ambiente hospitalar, elaborou-se um projeto de ensino de Música que integrou saberes oriundos das vivências dos discentes, associados aos conhecimentos definidos no currículo escolar. As reflexões apresentadas decorrem de experiências docentes em diálogo com compreensões no âmbito dos estudos teóricos sobre Educação Musical. Os resultados demonstraram intensa participação das crianças nas aulas de Música, cujos resultados indicam a importância do ensino de Música/Arte nas classes hospitalares, em especial, das expressões da cultura oral nos processos de ensino e aprendizagem. Propõe-se caminhos metodológicos que poderão contribuir para a formação de profissionais que tenham interesse em atuar nessa modalidade educacional.
tradição em movimento
Authors: Gonçalves Carlos Cleiton Evagelista , Laranjeira Carolina Dias
Published: September 2021

O artigo trata da discussão teórica que norteou uma pesquisa sobre possibilidades de ressignificações da dança popular na escola. O trabalho deu-se nas aulas de artes de uma escola do interior da Paraíba, com estudantes do ensino médio que estão imersos numa cultura local de produção de xaxado. Os padrões de movimento e as técnicas desta dança foram o ponto de partida para um trabalho artístico, no qual as abordagens aconteceram no sentido de promover a leitura e a transformação do movimento a partir de um processo de contextualização do mundo vivido pelo estudante. O artigo traz, entre outras, as contribuições de Nestor Garcia Canclini, Carlos Rodrigues Brandão e Isabel Marques para uma reflexão sobre como as danças populares se conectam com a modernidade, como o discurso da tradição ainda é um forte inibidor do trabalho com dança na escola e como é possível ressignificar a dança num processo criativo que tem a cultura popular como material.
Experimentações teatrais digitais com estudantes do ensino médio
Authors: Carvalho Jailson
Published: September 2021

Há algum tempo em que a escola discute sobre a utilização das tecnologias digitais contemporâneas como caminhos para a aprendizagem com  significação. O processo da inclusão tecnológica nos procedimentos metodológicos é algo crescente nos últimos anos. A partir destas reflexões que surge este artigo. O presente texto é resultado da minha dissertação de Mestrado em Artes (Prof-Artes), realizada no Instituto de Artes da Universidade de Brasília. O objetivo da pesquisa foi investigar e refletir sobre os processos de experimentações teatrais digitais com estudantes do ensino médio. O estudo de caso foi realizado no Centro Educacional 104 da Região Administrativa do Recanto das Emas, escola pública pertencente à Secretaria de Estado de Educação do Distrito Federal. A pesquisa contou com os seguintes procedimentos metodológicos: uma proposta pedagógica com 20 aulas de Teatro e Tecnologia, a criação de cinco produtos artísticos, avaliação com a utilização do WhatsApp, registro audiovisual e aplicação de um questionário online.
Encontros entre teatro, cotidiano e escola
Authors: Kloster Andressa
Published: September 2021

Esse artigo relata os processos criativos em teatro que foram realizados com duas turmas de nono ano do Ensino Fundamental II, em Curitiba, PR. Tais processos foram desenvolvidos unindo as temáticas relacionadas à diversidade, ao preconceito, às questões de gênero e especialmente às questões relacionadas à mulher, a partir do Teatro do Oprimido de Augusto Boal, especificamente o Teatro Imagem e o Teatro Jornal. O processo foi dividido em duas etapas, com o total de vinte encontros, cumpridos entre os meses de fevereiro a dezembro de 2017 buscando desenvolver a investigação e o desenvolvimento de senso crítico e reflexivo, resultando em três processos criativos em teatro. A revisão bibliográfica apresentada diz respeito às teorias relacionadas aos estudos de gênero, ao ensino de teatro na educação básica e ao Teatro do Oprimido. Para tanto foram considerados como principal aporte bibliográfico os autores Augusto Boal, Judith Butler e Guacira Lopes Louro.
Corpos em manifesto performático urbano
Authors: Nunes João Vítor Ferreira
Published: September 2021

Através deste artigo, pretendeu-se discutir acerca das teorias e noções de gênero, partindo da perspectiva da pensadora estadunidense Judith Butler (1990a; 2019b), de como as estruturas patriarcais são fortemente reproduzidas em contexto social, sobretudo por indivíduos que se encontram presos aos padrões culturalmente impostos pela heteronormatividade compulsória. Haja vista esses rituais de passagem (GENNEP, 2011) e rituais de crise de vida (TURNER, 2005), a artista-pesquisadora, proponente desta comunicação, em parceria com o Grupo de Pesquisa e Extensão Cruor Arte Contemporânea da UFRN e Homens Libertem-se, levou às ruas um manifesto para contestar e refletir acerca das imposições patriarcais, contribuindo a seu modo, para subverter essa realidade por meio da Performance Urbana. Por fim, ergue-se, desta maneira, um tripé de interlocução entre noções de gênero, padrões de comportamento e atos performáticos urbanos em coralidade.
Certification of Standard Reference Materials 2969 and 2970 :
Authors: Hahm Grace , Nelson Michael , Camara Johanna , Toman Blaza
Published: September 2021

Standard Reference Materials (SRMs) 2969 and 2970 are intended for 1) use in validating methods for determining concentrations of 25-hydroxyvitamin D2 (25(OH)D2) and 25-hydroxyvitamin D3 (25(OH)D3) in human serum and plasma and 2) value assigning in house produced control materials analyzed using those methods. A unit of SRM 2969 consists of two vials of frozen serum with a low total 25-hydroxyvitamin D (25(OH)D, the sum of 25(OH)D2 plus 25(OH)D3) concentrations. A unit of SRM 2970 consists of two vials of frozen serum with a relatively high 25(OH)D2 concentration. This publication documents the production, analytical methods, and statistical evaluations involved in characterization of these products.
Lokale opfattelser af den kvindelige krop og dens reproduktive rolle. Et eksempel fra Uganda
Authors: Neema Stella
Published: September 2021

The paper deals with Banyankole women of Southwestem Uganda and examines their perceptions of the female body and its reproductive processes. Data is based on qualitative ethnographic studies carried out for a period of one year in 1992 in Southwestem Uganda. The Kinyankole interpretation of the female body is seen in the framework of the biosocial body, both as a physical and a social body with norms and core values of society to be adhered to for protection against all natural and supernatural forces. The intemal structure is likened to the outside structure of the body, hence the ideas of “intemal breasts” feeding the fetus and “intemal oils” that have to cleansed out, just as the extemal body needs cleaning. Further, the author describes the Banyankole understanding of the growth of the fetus in stages of metamorphosis ending with childbirth as a process of “authentic cooking”. Local perceptions of the female body during pregnancy and childbirth shape women’s expectations, practices, and the resultant obstetrical care choices they opt for, and it is related to their own understanding of risk which might deviate from the biomedical concepts of risk during pregnancy and childbirth.
John Arundel Barnes: A Pack of Lies - Towards a Sociology of Lying
Authors: Raahauge Kirsten Marie
Published: September 2021

John Arundel Barnes: A Pack of Lies - Towards a Sociology of Lying

Anmeldes af Kirsten Marie Raahauge
Anne Knudsen & Lisanne Wilken: Kulturelle verdener: Kultur og kulturkonflikter i Europa
Authors: Alsmark Gunnar
Published: September 2021

Anne Knudsen & Lisanne Wilken: Kulturelle verdener: Kultur og kulturkonflikter i Europa

Anmeldes af Gunnar Alsmark
Christer Lindberg (red.): Antropologiska porträtt
Authors: Rønne Kirsten
Published: September 2021

Christer Lindberg (red.): Antropologiska porträtt

Anmeldes af Kirsten Rønne
Med Einstein i Australien. Rummet i etnografisk belysning
Authors: Fock Niels
Published: September 2021

This essay takes an empirical point of departure in the Australian aborigines’ conception of the world and its creation, as perceived through ‘dreaming’. It demonstrates that here routes are more important than roots in establishing an action-space which binds aborigines to their territories and landscapes. Time is integrated in space through movements in a two-dimensional, analogical picture of the land in which peoples act, move, and live. It is considered a field of forces, but in contrast to Einstein it has only two, not four dimensions, and it is defmitely not empty. By comparing conceptions of space among Amazonian and Andean Indians it is further possible to establish a distinction in worldviews equivalent to that of the geocentric universe versus the heliocentric one. Whereas the Amazonian Indians subscribe to a concentric system which makes them free to move, the Andes system establishes qualitatively divided areas with an optimal center which works against movements.
Lydene er musikkens græsrødder. Nogle betragtninger over lyd og rum
Authors: Westman Bror
Published: September 2021

Sound is characterised by distinctive phenomenological qualities. It creates a ‘sound scape’ that - as space sensed through the ears - wraps itself around the listener as an intimate atmosphere, without distance and clear dimensionality. Sounds are deeply interwoven with religious symbolism, e.g. as shamans incantate or pick up the auditory signals of gods or spirits. Cultural sound control spaces. Nostalgically, the church bells filled the parish, as today the ‘holy noise’ of traffic filis the urban spaces. But noise can also be used as artistic material, as in the works of the composer Russolo or in the planned landscape opera created by Winther, Hagen and the author.
Vigdis Broch-Due, Ingrid Rudie & Tone Bleie (eds.): Carved Flesh/Cast Selves: Gendered Symbols and Social Practices
Authors: Sørensen Bo Wagner
Published: September 2021

Vigdis Broch-Due, Ingrid Rudie & Tone Bleie (eds.): Carved Flesh/Cast Selves: Gendered Symbols and Social Practices

Anmeldes af Bo Wagner Sørensen
Richard J. Walter: Politics and Urban Growth in Buenos Aires: 1910-1942
Authors: Lund Julius
Published: September 2021

Richard J. Walter: Politics and Urban Growth in Buenos Aires: 1910-1942

Anmeldes af Julius Lund
DYRENE, DER IKKE BURDE EKSISTERE
Authors: Thomas Lars
Published: September 2021

Lars Thomas: The Animals that Shouldn’t

Exist

Strange and fantastic animals have always

been a part of human society. They lurk in

the comer of our eyes, when we walk

through a forest late at night, or pass through

a cemetery. Today most of these creatures

have been banished to the realm of fantasy

but, according to the modem science of

cryptozoology, some of the strange and supposedly

imaginary beings that are still seen

today, might be real animals, so far not

recognized by conventional zoological

science. Cryptozoologists study three different

types of animals: 1. Common species

seen in places where they shouldn't or

couldn’t be. 2. Well-known, but supposedly

extinct species still being seen. 3. Supposedly

fantastic or mythological beings that

might be real. Most conventional zoologists

are very sceptical towards these animals,

possibly because they challenge the normally

accepted view of the natural world.
Le dépôt légal des publications numériques au Québec
Authors: Pelbois Christelle , Lapointe Marie-Claude , Luckerhoff Jason
Published: September 2021

Le dépôt légal inscrit les bibliothèques nationales dans une triple mission : la collecte, la conservation et la diffusion. Or, le dépôt légal a été pensé et légalisé dans une période pré-numérique, de sorte que le dispositif législatif gagnerait à être repensé pour s’adapter à la nouvelle réalité. Nous avons voulu expliquer comment se fait le dépôt légal des publications numériques et proposer certains éléments de réflexion qui pourraient nourrir l’élaboration de nouveaux textes sur le dépôt légal ou aider à la révision de ceux déjà en vigueur. Dans le cadre d’une approche inductive et qualitative réalisée entre février et avril 2021, nous avons constitué différents corpus pour répondre à ces questions : des entretiens pour recueillir les discours sur le vécu et la réalité du livre numérique et du dépôt légal et l’analyse de plusieurs textes scientifiques et rapports de recherche. Les analyses sont présentées pour chaque mission des organismes dépositaires du dépôt légal.
Déploiements des archives, altérité et espaces de mémoires relationnels : pour une archivistique éthique anticoloniale
Authors: Dansereau François
Published: September 2021

Dans un contexte où la communauté archivistique internationale insiste sur la nécessité pour les nations autochtones d’être en contrôle des archives qui les concernent, cet article expose différentes problématiques qui nous amènent à réfléchir sur les particularités de l’environnement archivistique au Québec. En premier lieu, il signale les composantes coloniales de la production d’archives sur l’Île de la Tortue (Amérique du Nord) et la contribution des conceptions archivistiques traditionnelles au colonialisme d’implantation. Évoquant des énoncés mis en lumière par l’archivistique communautaire et les valeurs émancipatrices de l’archivistique, cet article propose une exploration de variables et paradigmes orientés vers la décolonisation des espaces de mémoire et des concepts archivistiques au Québec. Il fait ainsi part de l’effet structurant de l’archivistique et de la nécessité d’un engagement avec les conceptions de mémoire et ontologies autochtones afin de favoriser un développement de connaissances éthique. Cet article évoque alors le rôle, les responsabilités et les limites des archivistes et des institutions de mémoire concernant la résurgence autochtone.
Neuromonitoreo no invasivo en unidades de cuidados intensivos en Colombia
Authors: Ortiz Blair , Lanau Sara
Published: September 2021

El monitoreo electroencefalográfico no invasivo continuo es una técnica indispensable en los pacientes neurológicos críticos, ya que muestra de forma directa e indirecta su actividad cerebral y permite relacionar los hallazgos con su estado clínico. Es muy sensible, aunque su especificidad es menor, por lo que puede demostrar la alteración del estado de conciencia sin aclarar su etiología.El uso del registro electroencefalográfico continuo en pacientes con alteraciones del estado de conciencia, convulsiones, o estado epiléptico convulsivo y no convulsivo, se ha incrementado en los últimos años porque permite obtener información en tiempo real de la función cerebral y de los cambios en el tiempo; además, facilita la detección de crisis epilépticas subclínicas y electrográficas, estas últimas de gran importancia, ya que no presentan correlación clínica.Los hallazgos del monitoreo permiten modificar el tratamiento farmacológico y anticonvulsivo, y constituyen una gran ventaja para el médico tratante en la toma de decisiones oportunas que redunden en la mejoría del pronóstico del paciente.
Species diversity and community structure of crustacean zooplankton in the highland small waterbodies in Northwest Yunnan, China
Authors: Chen Xing , Cai Qinghua , Tan Lu , Liu Shuoran , Xiao Wen , Ye Lin
Published: September 2021

Small waterbodies are a unique aquatic ecosystem with an increasing recognition for their important role in maintaining regional biodiversity and delivering ecosystem services. However, small waterbodies in Northwest Yunnan, one of the most concerned global biodiversity hot-spots, remain largely unknown. Here, we investigated the community structure of crustacean zooplankton and their relationships with limnological, morphometric and spatial variables in the highland small waterbodies in Northwest Yunnan in both the dry (October 2015) and rainy (June 2016) seasons. A total of 38 species of crustacean zooplankton were identified in our study, which is significantly higher than many other reported waterbodies in the Yunnan–Guizhou plateau as well as in the Yangtze River basin. This suggests that the highland small waterbodies are critical in maintaining regional zooplankton diversity in Northwest Yunnan. Meanwhile, we found limnological variables could explain most variation of crustacean zooplankton community, comparing to the morphometric and spatial variables in both the rainy and dry seasons. Our study revealed the diversity and community structure of crustacean zooplankton in the highland small waterbodies in Northwest Yunnan and highlighted the importance of small waterbodies in maintaining regional biodiversity.
A nyers, a hőkezelt szójabab és az extrahált szójadara táplálóanyag-tartalma, 2016
Authors: Varga Edina , Tikász Ildikó Edit , Barna Andrea
Published: September 2021

Az Agrárgazdasági Kutató Intézet először teszi közzé a Magyarországon termesztett szójabab és származékai táplálóanyag-tartalmára vonatkozó közeli infravörös spektroszkópiás (NIR spektroszkópia) vizsgálati eredményeket. Az Evonik Nutrition & Care GmbH NIR kalibrációja a főbb táplálóanyag-paraméterek, az aminosav-tartalom, az emészthetőségi mutatók és az energiatartalom megállapítása mellett a hőkezelés minőségre gyakorolt hatásának az értékelését is lehetővé tette. A 2016. évi magyarországi szójatermés vonatkozásában összesen 53 minta (nyers szójabab, hőkezelt szójabab és extrahált szójadara) táplálóanyag-tartalmáról 83 különböző analitikai paraméter nyújt részletes információt, hogy a szójatermesztők és szójababfeldolgozók összevethessék saját eredményeiket az aggregált értékekkel. A NIR spektroszkópiás vizsgálati módszer alkalmazásával a növénytermesztésben a változások hatása nyomon követhetővé, a fajtaspecifikus jellegek időben ismertté válnak a gazdák számára, ami megbízhatóságot és kiszámíthatóságot garantál a partnerek felé.
Drug Utilization Pattern, Cost of Illness and Cost-Effective Analysis of Antihypertensive Drugs in a Tertiary Hospital- A Cross-Sectional Study
Authors: Ramanath K. V. , Biju Brijin Thomas , Ahmed Imad , Haritha Mandapati Veera Venkata , Kishore K. S.
Published: September 2021

Background: Hypertension is a condition with a substantial public health burden and a high risk of cardiovascular disease. The increasing prevalence of hypertension requires the use of cost-effective treatment and effective management of a disease. Hence, this study aims to assess the cost-effectiveness of antihypertension drugs in patients with hypertension and other co- morbidities.

Methods: The study was designed as prospective and interventional, with objectives to evaluate the cost of illness, prescribing patterns of different classes of antihypertensive drugs alone or in combination, and cost-effectiveness evaluation of other groups of antihypertensive drugs prescribed. Provided About 40 patients were with antihypertensive drugs of various classes whose health scores were calculated using the EQ-5D-5L questionnaire and calculated the total cost of treatment. Also calculated Most common Prescribe antihypertensive medications and the cost-effectiveness of each drug.

Results: This study showed that 58% of patients received combination therapy, 42% received monotherapy. Metoprolol was most cost-effective, followed by Carvedilol, which was in the case of monotherapy. Concerning combination therapy, Amlodipine + Bisoprolol proved to be the most cost-effective. ARBs were the most commonly prescribed class of antihypertensive drugs.

Conclusion: The study provided significant improvement in the health score of patients concerning the cost-effective antihypertensive treatment, showing an effective reduction in BP/ Helped in the management of hypertension and helped reduce risk factors associated with various cardiovascular diseases.
A Pine Shaped Dual-Band Frequency Reconfigurable Antenna
Authors: Sahu Shikha , Mohanta Harish Chandra
Published: September 2021

In recent years reconfigurable antennas have attracted a lot of attention in modern wireless communication systems. In satellite communication and ECM system, there has always been a continuous demand for smaller size, lighter weight antenna system that has properties to accomplish selectivity in frequency, bandwidth, polarization and gain. A frequency reconfigurable antenna is proposed for wireless communication. We can achieve Frequency reconfiguration by modifying physical or electrical dimensions of the antenna using RF-switches, impedance loading or tunable material. The design and simulation of the proposed antennas are done using ANSYS high-frequency structure simulator (HFSS) version-19. The proposed antenna is taken as a triangular shape whose length and width are 50mm and 25mm respectively. Here reconfigurability is achieved by RF switches placed in the radiator. The antenna analysis is done by taking different conditions of the switch. Total four switching condition is simulated and for each case, distinctive resonating frequencies are accomplished with acceptable reflection coefficient. The frequency bands of the antenna are varied from 2.12 GHz to 5.27 GHz. This antenna covers S-band and C band. After simulating the design the gain and efficiency of the antenna are verified successfully. Antenna fabrication and measurement of different parameters will be done in future. A comparison of the measured result will be analyzed with some existing antenna outcomes.
Determining the nutrient content, energy, and in vitro true digestibility of some grass forage plants
Authors: GÜRSOY Esra , KAYA Adem , GÜL Mehmet
Published: September 2021

The purpose of this study was to compare the chemical composition, metabolizable energy, net energy lactation, total digestible nutrient, in vitro digestion parameters, and relative feed quality of some grass forage plants growing naturally in the meadows and pastures of Erzurum province in Turkey. Orchardgrass (Dactylis glomerata), Variegated brome (Bromus variegatus), and Intermediate wheatgrass (Agropyron intermedium) were used as the research material. In this study, the metabolizable energy (ME) and net energy lactation (NEL) contents of the green grass crops forage plants were determined by in vitro gas production method, and their digestibility parameters and relative feed quality (RFQ) by the neutral detergent fiber (NDF) procedure using an Ankom Daisy incubator. As a result of the study, the differences between the forage plants were found to be statistically significant in terms of chemical composition, metabolizable energy, net energy lactation, true organic matter digestibility (TOMD) and RFQ (P<0.05). While the green intermediate wheatgrass was found to have the highest crude protein (CP) (19.56%), crude fat (CF) (3.06%), dry matter (DM) (9.14%), ME  (8.82%), NEL (5.42%), and TOMD (97.75%); the green variegated brome was found to have the highest RFQ (149.79). The green orchardgrass was found to have the highest contents of neutral detergent fiber (NDF), acid detergent fiber (ADF), and acid detergent lignin (ADL) with 66.23%, 34.14, and 8.52%, respectively. In conclusion, the green grass forage plants examined in this study can be used to eliminate the quality roughage deficit.
Protex 51FP as a starter for accelerating fish sauce fermentation from anchovy (Stolephorus commersonii)
Authors: Chau Le Minh , Ngoc Ho Thi Bich , Moreno Claire Donnay , Bruzac Sandrine , Bergé Jean-Pascal , Bergé Jean-Pascal , Hanh Vu Thi
Published: September 2021

In this 180-day study, commercial Protex 51FP enzyme effects as a starter culture on anchovy fish sauce fermentation were investigated. Three fish source fermentation groups, including a control group (the anchovy with 25% of salt addition), E group (the anchovy with 25% of salt and 1% of Protex 51FP addition), and E (-s) group (the anchovy with 1% of Protex 51FP and after 6 hours with 25% of salt), were compared. The fish sauce fermentation groups were sampled, packed into glass jars (10 liters), and covered by a lid at ambient temperature (22 - 30°C) for 180 days. Three commercial fish sauces were also included as nutritional references. The results showed that the addition of Protex 51FP achieved positive results of total nitrogen content and amino acids compared to the control samples (p<0.05). These values were competitive with commercial product figures. Total amino acids in 8000mg/100ml fish sauce were significantly higher than those in the control. There were rich in essential amino acids (41-43%) and small peptides (13% peptides with a molecular weight below 200 Da, 32-39% peptides with a molecular weight below 130 - 200 Da, and 25-28% of peptides with a molecular weight below 200 – 360 Da). Compared with traditional methods, the addition of Protex 51FP (p<0.05) could improve the quality of fish sauce and obtain greater nutritional values. In all experiments, the color of adding-enzyme samples was darker than that of the traditional products, and the smell of these samples (including traditional methods) was not as quite strong as commercial products.
PRICING STRATEGIES FOR NEW AGRICULTURAL PRODUCTS
Authors: Ademi Vjosa Fejza , Avdullahi Ajtene
Published: September 2021

Pricing strategies differ for each stage of the product life cycle. Although each stage of product life has its own peculiarities and challenges, the most difficult and challenging stage is setting prices for new products. Therefore, this was the reason which aroused our curiosity to do a research which is based on the theoretical and practical plane on this issue.

Initially, the literature of various authors who have contributed in the field of pricing policy for products and services in general was reviewed. Based on this analysis, a very good foundation has been laid to understand the role and importance of pricing for new products, and the most used pricing strategies for this category of products have described and analyzed. From the theoretical analysis, conclusions have been drawn which have served as a supporting basis of the practical part of the paper.

To make this research more thorough, we reviewed a special case study of the local manufacturing company Pestova l.l.c, which managed to launch several new products in the market of Kosovo and the Region. In this case study, the pricing strategies that this company has selected for the products launched in the market were analyzed.

Finally, the conclusions that have emerged as a result of the analysis and the literature review and the concrete data obtained from the case study for the company Pestova are provided.
Effectiveness of educational program for prevention of juvenile obesity / Efetividade de programa educativo para prevenção de obesidade juvenil
Authors: Gomes Josiane , Silva Dheinna , Costa Magila , Osawa Maristela , Barros Lívia Moreira
Published: September 2021

Objetivo: avaliar efetividade do programa educativo voltado para prevenção da obesidade entre adolescentes escolares, ancorado no modelo transteórico de mudança de comportamento. Método: estudo quantitativo do tipo quase-experimental de grupo único realizado em escola pública de ensino médio, na cidade de Sobral-Ceará com 39 adolescentes por meio da implementação de programa educativo. Resultados: o programa educativo foi efetivo na redução de variáveis antropométricas: peso (58,85 para 58,31, p=0,005); circunferência abdominal (73,5 para 72,65 cm, p=0,000); circunferência do quadril (91,65 para 90,75 cm, p=0,000) e índice de massa corporal (22,89 para 22,67 kg/m2, p=0,012). No M-1, a maioria dos estudantes estavam no estágio de pré-contemplação (66,7%). Ao longo dos momentos de coleta, observou-se discreto aumento no percentual de contemplação. Conclusão: intervenções educativas para prevenção da obesidade juvenil são ferramentas válidas para serem utilizadas por profissionais da saúde em conjunto com a escola, favorecendo a promoção da saúde e empoderamento de adolescentes.
Management of health care provided to quilombola men / Gestão do cuidado em saúde no contexto do homem quilombola
Authors: Dos Santos Felipe Valino , Leal Ataíde Rodrigues Ivaneide , Vidal Nogueira Laura Maria , Santos da Silva Ingrid Fabiane , Rego de Andrade Erlon Gabriel
Published: September 2021

Objetivo: Discutir a gestão do cuidado na dimensão da saúde do homem quilombola. Método: Estudo qualitativo, descritivo, desenvolvido em duas equipes da Estratégia Saúde da Família em comunidades quilombolas nos municípios de Ananindeua e Santa Izabel do Pará. Realizou-se entrevistas individuais com 17 participantes, entre profissionais das equipes e gestores municipais, no período de julho a setembro de 2017. Resultados: Utilizou-se a técnica de análise de conteúdo e organizou-se duas categorias temáticas: “Saberes e práticas de profissionais e gestores sobre as políticas públicas direcionadas ao homem quilombola” e “Fatores intervenientes para implementação das ações previstas nas políticas de saúde direcionadas ao homem quilombola”. Conclusão: Concluiu-se que é necessário avançar no desenvolvimento da díade “saberes-práticas” nos serviços de saúde, com os atores sociais envolvidos para prestar atendimento com qualidade, pois construir gestão compatível com os quilombolas é um desafio reconhecido por todos e pode contribuir para um cuidado integral nesses municípios.
Perception and attitude of parents towards newborn pain in neonatal unit / Percepção e atitude de pais diante da dor do filho recém-nascido internado em unidade neonatal
Authors: Roma Taiana Mara , Lamy Zeni Carvalho , Marques Ana Cláudia Garcia , Pereira Marina Uchoa Lopes , Mota Elainne , Lamy-Filho Fernando
Published: September 2021

Objetivo: compreender a percepção e a atitude de pais e mães de recém-nascidos internados em Unidade Neonatal sobre a dor de seus filhos. Método: pesquisa qualitativa, exploratória. Realizou-se vinte entrevistas semiestruturadas com genitores de neonatos abordando a relação entre profissionais de saúde e seus filhos, e sua abordagem ante eventos dolorosos. Realizou-se Análise de Conteúdo na modalidade temática. Resultados: os genitores perceberam dor pelo comportamento do filho e atribuíram como causa, procedimentos dolorosos e prematuridade. Alguns procedimentos não dolorosos foram elencados como tal, como retirada de esparadrapo. Mães, comparadas aos pais, apresentaram-se mais sensíveis à identificação da dor. Quanto à atitude diante desta, alguns citaram cuidados, outros, fuga e alguns relataram pedir ajuda aos profissionais. Conclusão: oferecer suporte aos pais pode fazer com que se sintam mais seguros para o cuidado do filho, mesmo diante da dor. Assim, podem assumir postura ativa diante da percepção da dor em seus recém-nascidos.
Theoretical/practical teaching in nursing graduation for mental health / Ensino teórico/prático na graduação em enfermagem para atuação em saúde mental
Authors: S.S. Nóbrega Maria do Perpétuo , Moreira Wanderson Carneiro , Chaves Suellen Cristina da Silva , Freitas Carolina Marques
Published: September 2021

Objetivo: analisar o ensino teórico/prático em Saúde Mental e Psiquiatria recebido durante a graduação em enfermagem. Método: estudo quantitativo, desenvolvido com 44 enfermeiros de uma Rede de Atenção Psicossocial do Município de São Paulo por meio de questionário validado. Resultados: 72,7% dos enfermeiros se sentem despreparados para lidar com Saúde Mental pela primeira vez, 68,2% consideram que o conteúdo foi pouco explorado e 84,1% tem interesse em fazer cursos na área. Conclusão: há dualidade no ensino teórico/prático ofertado pelas instituições de ensino superior, configurando a necessidade de que a formação seja revista para que enfermeiros generalistas consigam atender as demandas de Saúde Mental nos diversos campos de atuação profissional de acordo com o paradigma da Reforma Psiquiátrica e dos pressupostos da Reabilitação Psicossocial.
Microbiological and clinical profile of health care infections in a Pernambuco hospital / Perfil microbiológico e clínico de infecções relacionadas à assistência à saúde em um hospital de Pernambuco
Authors: Silva Juliana Kelly Batista da , Cabral Juliana da Rocha , Monteiro Edivane Patrícia Galdino , Cordeiro Maria Fernanda Franco Domingues , Freire Daniela de Aquino , Oliveira Regina Celia de
Published: September 2021

Objetivo: descrever o perfil microbiológico e clínico de infecções relacionadas à assistência à saúde (IRAS). Métodos: estudo epidemiológico, descritivo e retrospectivo. Utilizou-se dados de 78 notificações de IRAS de pacientes internados entre agosto/2016 a junho/2018. A coleta de dados ocorreu entre agosto a dezembro de 2018, a partir das fichas de notificações e registro de prontuários. Resultados: parte dos diagnósticos de infecções foi no grupo neoplasias 23,0%. Klebsiella pneumoniae obteve maior taxa de infecção, e foi a mais prevalente nos pacientes em uso de dispositivos invasivos. O tempo de uso de antibióticos por mais de 10 dias foi prevalente na associação com o diagnóstico de infecção primária de corrente sanguínea. Conclusão: são necessários estudos que visem medidas preventivas e o uso racional de antibióticos para corroborar com uma menor prevalência de IRAS e resistência bacteriana.
Role of aneuploid circulating tumor cells and CD31+ circulating tumor endothelial cells in predicting and monitoring anti‐angiogenic therapy efficacy in advanced NSCLC
Authors: Zhang Tongmei , Zhang Lina , Gao Yuan , Wang Ying , Liu Yanxia , Zhang Hongmei , Wang Qunhui , Hu Fanbin , Li Jie , Tan Jinjing , Wang Daisy Dandan , Gires Olivier , Lin Peter Ping , Li Baolan
Published: August 2021

Prognosticating the efficacy of anti‐angiogenic therapy through longitudinal monitoring and early detection of treatment resistance in cancer patients remain highly challenging. In this study, co‐detection and comprehensive phenotypic and karyotypic molecular characterization of aneuploid circulating tumor cells (CTCs) and circulating tumor endothelial cells (CTECs) were conducted on non‐small cell lung cancer (NSCLC) patients receiving bevacizumab plus chemotherapy. Prognostic values of the cell‐based significant univariate risk factors identified by Cox regression analyses were progressively investigated. Subjects showing an increase in total post‐therapeutic platelet endothelial cell adhesion molecule‐1 (CD31)– CTCs and CD31+ CTECs exhibited a significantly reduced median progression‐free survival (mPFS) and overall survival. Further stratification analyses indicated that pretherapeutic patients bearing vimentin (Vim)+ CTECs (mesenchymal M‐type) at baseline revealed a significantly shortened mPFS compared with patients with Vim– CTECs. Post‐therapeutic patients harboring epithelial cell adhesion molecule (EpCAM)+ CTCs and CTECs (epithelial E‐type), regardless of Vim expression or not, showed a significantly reduced mPFS. Post‐therapeutic patients possessing de novo EpCAM+/Vim+ (hybrid E/M‐type) CTECs displayed the shortest mPFS. Patients harboring either pre‐ or post‐therapeutic EpCAM–/Vim– null CTECs (N‐type) exhibited a better response to therapy compared to patients harboring EpCAM+ and/or Vim+ CTECs. The presented results support the notion that baseline Vim+ CTECs and post‐therapeutic EpCAM+ CTCs and CTECs are predictive biomarkers for longitudinal monitoring of response to anti‐angiogenesis combination regimens in NSCLC patients.
Structural and functional insights into lysine acetylation of cytochrome c using mimetic point mutants
Authors: Márquez Inmaculada , Pérez‐Mejías Gonzalo , Guerra‐Castellano Alejandra , Olloqui‐Sariego José Luis , Andreu Rafael , Calvente Juan José , De la Rosa Miguel A. , Díaz‐Moreno Irene
Published: August 2021

Post‐translational modifications frequently modulate protein functions. Lysine acetylation in particular plays a key role in interactions between respiratory cytochrome c and its metabolic partners. To date, in vivo acetylation of lysines at positions 8 and 53 has specifically been identified in mammalian cytochrome c, but little is known about the structural basis of acetylation‐induced functional changes. Here, we independently replaced these two residues in recombinant human cytochrome c with glutamine to mimic lysine acetylation and then characterized the structure and function of the resulting K8Q and K53Q mutants. We found that the physicochemical features were mostly unchanged in the two acetyl‐mimetic mutants, but their thermal stability was significantly altered. NMR chemical shift perturbations of the backbone amide resonances revealed local structural changes, and the thermodynamics and kinetics of electron transfer in mutants immobilized on gold electrodes showed an increase in both protein dynamics and solvent involvement in the redox process. We also observed that the K8Q (but not the K53Q) mutation slightly increased the binding affinity of cytochrome c to its physiological electron donor, cytochrome c1—which is a component of mitochondrial complex III, or cytochrome bc1—thus suggesting that Lys8 (but not Lys53) is located in the interaction area. Finally, the K8Q and K53Q mutants exhibited reduced efficiency as electron donors to complex IV, or cytochrome c oxidase.
The Arbitrator as Referee
Authors: Feit Norman
Published: August 2021

As a neutral, I stand between the combatants, constantly seeking perspectives that offer the best view of the action, while maintaining a fair and even‐handed venue by making periodic decisions that reflect the practical dynamics of the contest, rather than a strict application of the rules.
A Look Back at Where English and U.S. Arbitration Law Comes From: The Long 18th Century
Authors: Samuel Adam
Published: August 2021

Two great English enthusiasts for arbitration history, Derek Roebuck and Johnny Veeder, died in the spring of 2020. Derek was a legal historian and an author of a series of books on the subject. Johnny was one of the top English practicing barristers and arbitrators.
Synthesis and morphological studies of Tc‐99m‐labeled lupulone‐conjugated Fe3O4@TiO2 nanocomposite, and in vitro cytotoxicity activity on prostate cancer cell lines
Authors: Tutun Elif , Tekin Volkan , Yasakcı Volkan , Aras Ömer , Ünak Perihan
Published: September 2021

The purpose of this study was to develop a multifunctional theranostic probe for imaging (magnetic resonance imaging [MRI] and single‐photon emission computed tomography [SPECT]) and therapy (photodynamic therapy). For this purpose, Tc‐99m‐labeled lupulone‐conjugated Fe3O4@TiO2 nanocomposites (99mTc‐DTPA‐Fe3O4@TiO2‐HLP and 99mTc‐DTPA‐Fe3O4@TiO2‐ALP nanocomposites) were synthesized. The average diameter of the nanocomposites was 171 ± 20 nm as seen on transmission electron microscopy images. Fe3O4@TiO2 nanocomposites exhibited fluorescence spectra at an emission wavelength of 314 nm. Lupulone‐conjugated Fe3O4@TiO2 nanocomposites were spherical‐shaped with a suitable dispersion and without visible aggregation, and their radiolabeling yields were over 85%. Healthy (RWPE‐1 normal human prostate epithelial cell line) and cancer prostate cell lines (PC‐3 human prostate cancer cell line) were used to determine the in vitro biological behavior of the nanocomposites. The PC‐3 cells treated with lupulone‐conjugated Fe3O4@TiO2 nanocomposites showed a lower cell viability compared with RWPE‐1 cells treated with lupulone‐conjugated Fe3O4@TiO2 nanocomposites. Lupulone‐modified Fe3O4@TiO2 nanocomposites may serve in the future as a multifunctional probe for positron emission tomography (PET)/MRI, photodynamic therapy, and hyperthermia therapy of cancer.