bluuebunny/crossref_metadata_2025 huggingface dataset:
Single-shot detection of bacterial spores with Yb-laser-based CARS spectroscopy
Authors: Coluccelli Nicola , Cichelli Giovanni , Laporta Paolo , Cerullo Giulio
Published: June 2023

We present a system based on a high-energy femtosecond ytterbium laser seeding an optical parametric amplifier and a photonic crystal hollow core fiber (PCHCF) compressor for coherent anti-Stokes Raman scattering (CARS) spectroscopy. The PCHCF provides spectral broadening of the Stokes pulse which is then compressed to a duration matched to that of the pump pulse. In these conditions, the excitation efficiency of vibrational levels in the target molecules is largely improved, as the time gating effect due to the mismatch between the durations of the pump and Stokes pulses is avoided. Experiments are presented along with a theoretical model to quantify expected improvement of sensitivity. The system is used to detect bacterial spores deposited on a surface with a single laser shot at unprecedented signal-to-noise ratio.
Global report on COVID-19 vaccination and reasons not to vaccinate among adults with intellectual disabilities: Results from secondary analyses of Special Olympics’ program planning
Authors: Lincoln Andrew E. , Dixon-Ibarra Alicia M. , Hanley John P. , Smith Ashlyn L. , Martin Kiki , Bazzano Alicia
Published: June 2023

The COVID-19 pandemic has disproportionately affected people with intellectual disabilities worldwide. The objective of this study was to identify global rates of COVID-19 vaccination and reasons not to vaccinate among adults with intellectual disabilities (ID) associated with country economic income levels. The Special Olympics COVID-19 online survey was administered in January-February 2022 to adults with ID from 138 countries. Descriptive analyses of survey responses include 95% margins of error. Logistic regression and Pearson Chi-squared tests were calculated to assess associations with predictive variables for vaccination using R 4.1.2 software. Participants (n = 3560) represented 18 low (n = 410), 35 lower-middle (n = 1182), 41 upper-middle (n = 837), and 44 high (n = 1131) income countries. Globally, 76% (74.8–77.6%) received a COVID-19 vaccination while 49.5% (47.9–51.2%) received a COVID-19 booster. Upper-middle (93% (91.2–94.7%)) and high-income country (94% (92.1–95.0%)) participants had the highest rates of vaccination while low-income countries had the lowest rates (38% (33.3–42.7%)). In multivariate regression models, country economic income level (OR = 3.12, 95% CI [2.81, 3.48]), age (OR = 1.04, 95% CI [1.03, 1.05]), and living with family (OR = 0.70, 95% CI [0.53, 0.92]) were associated with vaccination. Among LLMICs, the major reason for not vaccinating was lack of access (41.2% (29.5–52.9%)). Globally, concerns about side effects (42%, (36.5–48.1%)) and parent/guardian not wanting the adult with ID to vaccinate (32% (26.1–37.0%)) were the most common reasons for not vaccinating. Adults with ID from low and low-middle income countries reported fewer COVID-19 vaccinations, suggesting reduced access and availability of resources in these countries. Globally, COVID-19 vaccination levels among adults with ID were higher than the general population. Interventions should address the increased risk of infection for those in congregate living situations and family caregiver apprehension to vaccinate this high-risk population.
Global incidence in hospital-associated infections resistant to antibiotics: An analysis of point prevalence surveys from 99 countries
Authors: Balasubramanian Ruchita , Van Boeckel Thomas P. , Carmeli Yehuda , Cosgrove Sara , Laxminarayan Ramanan
Published: June 2023

Background

Hospital-associated infections (HAIs) are an important cause of morbidity and mortality around the world. Many HAIs are caused by drug-resistant bacterial pathogens, but there are major gaps in our understanding of the number of hospital-associated drug-resistant infections (HARIs) worldwide. As such, we estimated trends in prevalence of HARIs caused by high priority pathogens (Escherichia coli, Acinetobacter spp., Klebsiella spp., Staphylococcus aureus, Enterobacter spp., and Pseudomonas spp.) in 195 countries.

Methods and findings

Resistance prevalence estimates were extracted from 474-point prevalence surveys (PPS) from 99 countries published between 2010 and 2020 coupled with country-level estimates of hospitalization rates and length of stay. Prevalence estimates were transformed in yearly incidence of HARIs per year by country and income group. We estimate the global number of HARIs per year to be 136 million (95% credible interval (CI) 26 to 246 million) per year, with the highest burden in China (52 million, 95% CI 10 to 95 million), Pakistan (10 million, 95% CI 2 to 18 million), and India (9 million, 95% CI 3 to 15 million). Among income groups, middle-income countries bore the highest burden of HARIs per year (119 million, 95% CI 23 to 215 million). Our analysis was constrained by the limited number of PPS for HARIs, lack of community-associated data on antibiotic-resistant infections, and our population level analysis.

Conclusions

In this study, we observe, in the absence of systematic surveillance systems for HARIs, a baseline overview of their rates. Our yearly estimates highlight the global threat of HARIs and may help define strategies to tackle resistance in hospital settings.
Genetic features of Sri Lankan elephant, Elephas maximus maximus Linnaeus revealed by high throughput sequencing of mitogenome and ddRAD-seq
Authors: Sooriyabandara M. G. C. , Jayasundara J. M. S. M. , Marasinghe M. S. L. R. P. , Hathurusinghe H. A. B. M. , Bandaranayake A. U. , Jayawardane K. A. N. C. , Nilanthi R. M. R. , Rajapakse R. C. , Bandaranayake P. C. G.
Published: June 2023

Elephas maximus maximusLinnaeus, the Sri Lankan subspecies is the largest and the darkest among Asian elephants. Patches of depigmented areas with no skin color on the ears, face, trunk, and belly morphologically differentiate it from the others. The elephant population in Sri Lanka is now limited to smaller areas and protected under Sri Lankan law. Despite its ecological and evolutionary importance, the relationship between Sri Lankan elephants and their phylogenetic position among Asian elephants remains controversial. While identifying genetic diversity is the key to any conservation and management strategies, limited data is currently available. To address such issues, we analyzed 24 elephants with known parental lineages with high throughput ddRAD-seq. The mitogenome suggested the coalescence time of the Sri Lankan elephant at ~0.2 million years, and sister to Myanmar elephants supporting the hypothesis of the movement of elephants in Eurasia. The ddRAD-seq approach identified 50,490 genome-wide SNPs among Sri Lankan elephants. The genetic diversity within Sri Lankan elephants assessed with identified SNPs suggests a geographical differentiation resulting in three main clusters; north-eastern, mid-latitude, and southern regions. Interestingly, though it was believed that elephants from the Sinharaja rainforest are of an isolated population, the ddRAD-based genetic analysis clustered it with the north-eastern elephants. The effect of habitat fragmentation on genetic diversity could be further assessed with more samples with specific SNPs identified in the current study.
Analytic and holistic cognitive style as a set of independent manifests: Evidence from a validation study of six measurement instruments
Authors: Lacko David , Prošek Tomáš , Čeněk Jiří , Helísková Michaela , Ugwitz Pavel , Svoboda Vojtěch , Počaji Peter , Vais Matěj , Halířová Helena , Juřík Vojtěch , Šašinka Čeněk
Published: June 2023

Cognitive styles are commonly studied constructs in cognitive psychology. The theory of field dependence-independence was one of the most important cognitive styles. Yet in the past, its measurement had significant shortcomings in validity and reliability. The theory of analytic and holistic cognitive styles attempted to extend this theory and overcome its shortcomings. Unfortunately, the psychometric properties of its measurement methods were not properly verified. Furthermore, new statistical approaches, such as analysis of reaction times, have been overlooked by current research. The aim of this pre-registered study was to verify the psychometric properties (i.e., factor structure, split-half reliability, test-retest reliability, discriminant validity with intelligence and personality, and divergent, concurrent and predictive validity) of several methods routinely applied in the field. We developed/adapted six methods based on self-report questionnaires, rod-and-frame principles, embedded figures, and hierarchical figures. The analysis was conducted on 392 Czech participants, with two data collection waves. The results indicate that the use of methods based on the rod-and-frame principle may be unreliable, demonstrating no absence of association with intelligence. The use of embedded and hierarchical figures is recommended. The self-report questionnaire used in this study showed an unsatisfactory factor structure and also cannot be recommended without futher validation on independent samples. The findings also did not correspond with the original two-dimensional theory.
Defining the minimum inhibitory concentration of 22 rifamycins in iron limited, physiologic medium against Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae clinical isolates
Authors: Lu Peggy , Alletto Francesco , Lee Bosul , Burk Elizabeth , Martinez Jasmine , Prati Fabio , Caselli Emilia , Spellberg Brad , Luna Brian
Published: June 2023

Recently, we reported rifabutin hyper-activity against Acinetobacter baumannii. We sought to characterize if any additional rifamycins (n = 22) would also display hyper-activity when tested in iron-limited media against A. baumannii, K. pneumoniae, and E. coli. MICs were determined against representative clinical isolates using the iron-limited media RPMI-1640. Only rifabutin was hyperactive against A. baumannii.
Basics of faculty-to-faculty mentoring: A process to identify support and challenges
Authors: Zehra Tabassum , Tariq Muhammed , Rehman Rehana , Zuberi Rukhsana W.
Published: June 2023

Faculty mentoring is relatively new in health sciences literature. Faculty mentors are considered to have multiple roles including being a supervisor, teacher, or a coach. Little or no attention to formal mentoring of faculty allows faculty to seek informal mentoring, creating a risk of unexpected outcome. There is dearth of literature with respect to formal mentoring programs from the subcontinent. Although, informal faculty mentoring has been in place but there is no standard faculty mentorship model to be followed at Aga Khan University Medical College (AKU-MC). An observational study was conducted in September 2021 at AKU MC with convenient sampling to share the perceptions of the AKU-MC faculty mentors in a faculty mentorship workshop so that further advanced level faculty development workshops could be planned in this area. Twenty-two faculty mentors participated to share their perspectives on the responsibilities of faculty mentor, faculty mentee and the institution to see faculty grow and to have a sustainable mentorship programme. Challenges faced by the faculty mentors during the process of mentorship were also discussed. Majority of the participants emphasized on the role of the faculty mentor to be supportive, guiding, reflective and formative (respond to the emotional needs, encourage, effective communication, know own limitations, observe, provide feedback). Faculty mentor role modeling, ability to maintain confidentiality, creating and maintaining mentor-mentee relationship, availability of framework of formal mentoring in an academic institution and opportunities within the academic setting to learn mentorship were the main challenges of being a faculty mentor. The process provided valuable training and education to the faculty for the development and strengthening of formal mentoring program. Faculty recommended that institutions should provide the opportunity for development of junior faculty mentors by organizing capacity building activities.
Relationship between anthropometric and body composition parameters and anti-SARS-CoV-2 specific IgG titers in females vaccinated against COVID-19 according to the heterologous vaccination course: A cohort study
Authors: Golec Marlena , Zembala-John Joanna , Fronczek Martyna , Konka Adam , Bochenek Aneta , Wystyrk Karolina , Botor Hanna , Zalewska Marzena , Chrapiec Martyna , Kasperczyk Sławomir , Brzoza Zenon , Bułdak Rafał J.
Published: June 2023

Introduction

The aim of this cohort study was to evaluate the relationship between anthropometric and body composition parameters and anti-SARS-CoV-2 IgG titers in a group of females who were vaccinated against COVID-19 with two doses of ChAdOx1 vaccine and then boosted with the BNT162b2 vaccine.

Materials and methods

The study group consisted of 63 women. Basic demographic and clinical data were collected. To assess the anti-SARS-CoV-2 immunoglobulin G titers following the vaccination, five blood draws were performed: 1) before the first dose, 2) before the second dose, 3) 14–21 days after the primary vaccination, 4) before the booster, and 5) 21 days after the booster. Blood samples were analyzed using a two-step enzymatic chemiluminescent assay. Body mass index and body composition were evaluated using bioelectrical impedance analysis. To select the most distinguishing parameters and correlations between anthropometric and body composition parameters and anti-SARS-CoV-2 IgG titers, factor analysis using the Principal Component Analysis was conducted.

Results

Sixty-three females (mean age: 46.52 years) who met the inclusion criteria were enrolled. 40 of them (63.50%) participated in the post-booster follow-up. After receiving two doses of the ChAdOx1 vaccine, the study group’s anti-SARS-CoV-2 IgG titers were 67.19 ± 77.44 AU/mL (mean ± SD), whereas after receiving a heterologous mRNA booster, the level of anti-SARS-CoV-2 IgG titers was about three-times higher and amounted to 212.64 ± 146.40 AU/mL (mean ± SD). Our data shows that seropositivity, obesity, non-fat-related, and fat-related body composition parameters all had a significant effect on the level of IgG titer after a two-dose vaccination of ChAdOx1. However, only non-fat-related and fat-related body composition parameters had a significant effect on the IgG titer after booster vaccination.

Conclusion

COVID-19 infection before the first dose of vaccination is not related to IgG titer after booster administration. Body composition has a significant effect on the production of anti-SARS-CoV-2 IgG after booster vaccination in females.
Companhia da Ilha do Príncipe (Portugal/São Tomé e Príncipe), 1894-1975: Desenvolvimento de um Projeto Agrícola e Gestão do Grupo CUF
Authors: Amado Mendez José , Freitas Duarte Manuel
Published: June 2023

Nascida em Lisboa como Sociedade Anónima de Responsabilidade Limitada, a Companhia da Ilha do Príncipe deteve como objetivo principal a exploração, em São Tomé e Príncipe – território insular no Atlântico Equatorial, nas proximidades da costa africana, sob a administração portuguesa –, de uma agricultura intensiva assente, essencialmente, no cacau, com o início da sua atividade a ocorrer em 1894. Foram várias as personalidades no mundo empresarial português que tomaram ações ou tiveram envolvidas na sua administração, com particular destaque para os sucessores do industrial Alfredo da Silva – fundador do grupo CUF –, que se encontravam à frente da empresa já na década de 1950, permanecendo até ao ano do seu encerramento, em 1975. Para além da identificação dos fundadores, acionistas, principais gestores e administradores, pretende-se, com o presente artigo, efetuar um exercício de história empresarial a partir das fontes consultadas – com particular destaque para os Relatórios e Contas anuais –, que passe, de igual modo, pela compreensão dos meandros de uma produção agrícola de caráter intensivo, da mão de obra empregue, dos espaços e equipamentos industriais utilizados e das limitações e linhas de força da gestão e administração das roças pertencentes à referida Companhia.
Explorando a Definição Multimodal
Authors: Sabino-Luiz Marcelo
Published: June 2023

A definição lexicográfica é uma parte crucial da microestrutura de um dicionário e tem uma função metalinguística importante na caracterização do sentido de cada unidade léxica. Ela se baseia principalmente na linguagem verbal e, como defendido por Jackson (2002), a definição é uma “forma de linguagem voltada para si mesma” que utiliza a própria linguagem para descrever o significado de cada lexema. Com a evolução da tecnologia, novas modalidades de linguagem não verbal, como fotografias, vídeos e áudios, estão se tornando recursos importantes na estruturação de um dicionário para atender às necessidades dos usuários. O conceito de "definição multimodal" refere-se, por sua vez, à integração da linguagem verbal com outras formas de linguagem não verbal, tanto humanas quanto não-humanas, tendo o potencial de mostrar o significado do referente em questão, utilizando múltiplas semioses. Em contextos educacionais, o uso da abordagem multimodal pode ser útil para garantir a plena compreensão dos conceitos que estão sendo ensinados. Neste estudo, preocupamos em destacar as potencialidades das ilustrações para a prática atual de produção de dicionários impressos. Selecionamos três dicionários escolares do Programa Nacional do Livro Didático (PNLD) do TIPO-2 e utilizamos a metodologia proposta por Svensén (2009) para categorizar as ilustrações presentes nesses repertórios. Nosso objetivo geral foi entender de que maneira as ilustrações podem contribuir para o significado do texto lexicográfico, e quais tipos delas são mais eficientes para auxiliar no entendimento de cada sentido de uma unidade lexical. Observamos que os dicionários escolares impressos analisados nem sempre utilizam as ilustrações de forma consistente, e embora não tenhamos realizado uma análise detalhada sobre essa problemática, sugerimos que o contexto digital pode ser mais apropriado para aproveitar ao máximo os recursos multimodais disponíveis.
Avaliação do Uso Integrado de Imagens de Nanossatélites e Classificadores baseados em Aprendizado de Máquina para Estudos da Dinâmica Hidrológica na Região da Nhecolândia (Pantanal)
Authors: Dias Ramos Mariana , Merino Eder Renato , Montes Célia Regina , Melfi Adolpho José
Published: June 2023

A região da Baixa Nhecolândia é uma das paisagens mais icônicas da Bacia do Pantanal. Sua morfologia única é composta por mais de 10.000 lagoas com águas salino-alcalinas e água doce que coexistem em uma área aproximada de 12.000 km². Essa região está sujeita a alagamentos sazonais que atuam no escoamento superficial, porém, pouco se conhece sobre sua dinâmica de inundação. Avanços recentes na área do geoprocessamento têm ajudado a ampliar nosso conhecimento sobre ambientes lacustres. Este trabalho teve como objetivo avaliar o desempenho de dois classificadores supervisionados baseados em aprendizado de máquina (Support Vector Machine e Random Forest), para a caracterização da dinâmica hidrológica da região da Nhecolândia. Os classificadores foram aplicados em imagens de nanossatélites (PlanetScope) por meio da plataforma de computação em nuvem Google Earth Engine. Os resultados evidenciaram o desempenho satisfatório e semelhante dos dois classificadores.
Analysis on generalized Clifford algebras
Authors: Orelma Heikki
Published: June 2023

Изучается вопрос, связанный с обобщенными алгебрами Клиффорда $\mathcal{C}_n(\underline{a})$, где $\underline{a}$ - ненулевой вектор. Если $\{e_1,…,e_n\}$ - ортонормированный базис, операция умножения определяется соотношениями \begin{align*}
e_j^2=a_je_j-1,
e_ie_j+e_je_i=a_ie_j+a_je_i,
\end{align*}
где $a_j=e_j\cdot\underline{a}$. Случай $\underline{a}=\underline{0}$ соответствует классической алгебре Клиффорда. Определяется оператор Дирака $D=\sum_je_j\partial_{x_j}$ и регулярные функции как его нулевое решение. Изучаются алгебраические свойства рассматриваемой алгебры. Доказываются основные формулы для оператора Дирака и изучаются свойства регулярных функций.
كۆيە لە شاڵاوى ئەنفالى چواردا
Authors: عولا کۆسرەت اکرم , مەحمود هۆشمەند
Published: June 2023

ئەم توێژینەوەیە، تیشک دەخاتە سەر ئەنفالی کۆیە و ناحیە و گوندەکانی، کە حکومەتی  عێراق لە ٢٣ شوبات تا ٦ ئەیلولی ساڵی ١٩٨٨ شاڵاوەكانى ئەنفالی بە چەند قۆناغێک بەرامبەر بە گەلى کورد ئەنجامداوە، لە ٣- ٧ ئايارى ١٩٨٨ لە چوارچێوەی شاڵاوى قۆناغی ئەنفالی چواردا، هەمو گوندەکانی قەزای کۆیە بەر شاڵاوى ئەنفال کەوتون و لەگەڵ زەوی تەختکراون، هەندێک لە دانیشتوانی گوندەکانی (کڵێسە، گۆمەشین، کانی ڕەش)خەڵکەکەی لە گوندەکانی خۆیان دەستگیرکراون و کەوتونەتە بەرشاڵاوى ئەنفال، لە چوارچێوەی ئەنفالی کۆیە تاکە بەرگريی هێزی پێشمەرگە لە شەڕی چیای سیتەغار بووە، کە نۆ پێشمەرگە کوژاون، لە ڕۆژی 9ئايارى 1988يشدا کۆیە وەک یەکەمین شار لە کوردستان بەر شاڵاوى ئەنفال کەوتووە، خەڵکێکی زۆری هەمو گوندەکان کە پێشتر ڕویان لە شارەكە کردووە، لە ئەنجامی پشکنینی گەڕەکەکانی کۆیە و ماڵی سەرۆك جاشەكان دەستگیركراون، کە ئەو ڕۆژە بە ڕۆژی ڕەشبگیریيەکەی ئەنفال لە کۆیە ناسراوە، ئەنفالکراوانی سنوری کۆیە لە چەند وێستگەیەک کۆکراونەتەوە، پاشان بردراون بۆ تۆبزاوای کەرکوک و لەوێشەوە ڕەوانەی نوگرە سەلمان کراون، لە ئەنجامی ئەنفالی سنوری کۆیە ٨٥١ کەس بێ سەر و شوێن کراون ، بەوهۆیەوە کێشەیەکی زۆری ئابوريی، کۆمەڵایەتی، دەرونی بۆ کەسوکاری ئەنفالکراوان دروستبووە، کە تا ئێستاش کاریگەریيەکانی هەرماون.
Antagonistic Mechanism of Entomopathogenic Fungi Against Fusarium oxysporum f. sp. cubense, The Causal Agents of Banana’s Panama Disease
Authors: Listiyowati Sri , Rustiani Tya , Rahayu Gayuh
Published: June 2023

Fusarium oxysporum f. sp. cubense merupakan cendawan tular tanah penyebab penyakit panama pada tanaman pisang. Agens hayati dari kelompok cendawan telah banyak dilakukan untuk mengendalikan penyakit tanaman.  Oleh sebab itu, penelitian ini bertujuan mengidentifikasi empat koleksi cendawan entomopatogen berdasarkan pada ciri morfologinya dan mengevaluasi mekanisme antagonismenya terhadap F. oxysporum f. sp. cubense IPBCC 19 1472. Galur cendawan entomopatogen dengan kode PS 4, PS 9, PS 11  berasal dari kawasan Situ Gunung, Sukabumi, Jawa Barat dan galur KRC berasal dari Kebun Raya Cibodas, Jawa Barat. Identifikasi cendawan dilakukan berdasarkan ciri morfologi pada medium agar-agar dekstrosa kentang. Mekanisme antagonistik diteliti menggunakan metode biakan ganda dan sebagai kontrol digunakan biakan tunggal F. oxysporum f. sp. cubense. Pengamatan dilakukan terhadap daya hambat cendawan entomopatogen dan pertumbuhan koloni F. oxysporum f. sp. cubense. Semua cendawan entomopatogen tidak dapat diidentifikasi secara morfologi karena tidak bersporulasi. Pertumbuhan koloninya lebih lambat daripada F. oxysporum f. sp. cubense. Semua cendawan entomopatogen menghambat F. oxysporum f. sp. cubense melalui mekanisme kompetisi ruang. Galur KRC memiliki aktivitas antagonisme paling besar, diikuti berturut-turut oleh galur PS 9, PS 11, dan PS 4. F. oxysporum f. sp. cubense membentuk klamidospora sebagai respons terhadap cendawan entomopatogen galur PS9 dan vakuolisasi ketika berinteraksi dengan tiga galur cendawan entomopatogen lainnya.
Roman Baron, Misja życia. Praski polonista Marian Szyjkowski (1883–1952) a idea polsko-czeskiego zbliżenia na polu kultury
Authors: Ďurčanský Marek
Published: June 2023

Book review on Roman Baron, Misja życia. Praski polonista Marian Szyjkowski (1883–1952) a idea polsko-czeskiego zbliżenia na polu kultury. Instytut Historii im Tadeusza Manteuffla Polskiej Akademii Nauk – Historický ústav Akademie věd České republiky, Warszawa – Praga 2019, 370 s. + 18 s. obrazových příloh, ISBN 978-83-65880-72-7 (IH PAN), 978-80-7286-343-3 (HÚ AV ČR).
Asistent Fyzikálního ústavu Německé univerzity v Praze v letech 1906–1914 se „slibným“ jménem Weiss a měření elementárního elektrického náboje
Authors: Těšínská Emilie
Published: June 2023

This study is dedicated to the Austrian physicist Edmund Weiss (1884–1932) and his time as assistant at the Institute of Physics of the German University in Prague in 1906–1914. Particular attention is paid to his 1911 habilitation work on the elementary quantum of electricity, which he measured in experiments with ultramicroscopic silver particles. In this work, Weiss repeated the measurements of Vienna physicist Felix Ehrenhaft. Unlike he, Weiss managed to confirm – with the help of Einstein’s 1905 formula for Brownian molecular motion – the value of elementary quantum of electricity, which had first been established by R. A. Millikan in his ‘oil drop’ experiments. Albert Einstein, at that time (in 1911–1912) professor of theoretical physics at the German University in Prague, praised Edmund Weiss and his work at the First Solvay Conference on Physics in Brussels in autumn 1911. Details of Weiss’s habilitation work at the Institute of Physics in Prague were described in letters written by Anton Lampa, professor and director of the institute, and addressed to the doyen of Viennese physics Viktor von Lang. Full texts of six of Lampa’s letters (in German) are appended to the study.
12. sjezd českých historiků v Ústí nad Labem (20.–22. září 2022) pohledem dějin vědy, vzdělanosti a lékařství
Authors: Brčák Marek , Ďurčanský Marek , Svobodný Petr
Published: June 2023

Conference Report
10. mezinárodní konference Evropské společnosti pro dějiny vědy
Authors: Sekyrková Milada
Published: June 2023

Conference Report
Biofilm inhibitory potential of Oscillatoria tenuis against Candida albicans
Authors: Deepa K. P , Thajuddin N
Published: June 2023

Prokaryotic autotrophs have a key role in maintaining the sustainability of nature. Their secondary metabolites and stored chemicals have wide utility in human life. Cyanophytes, the primitive producers, can become a necessity of the modern world as they have enormous unexplored features. Candida albicans, an opportunistic pathogen having multidrug resistance, fallout health concerns in human and animal hosts. This study focused on the antibiofilm potential of Oscillatoria tenuis NTAPD 02, isolated from a hydrocarbon-polluted area against the hyphal switching of Candida albicans. Ethanolic extract of the algal sample, OEE, was taken to perform the biofilm quantification test and CLSM studies to determine the antibiofilm potential of Oscillatoria tenuis against Candida albicans. The MBIC for OEE was found to be 30 µg/mL against C. albicans and also shows a 70.8% reduction of fungal biofilm. The GC-MS and FTIR analysis illustrates the presence of potent phenolic hydrocarbons having an anti-proliferative effect. OEE was also found stress generative in C. elegans (500 µg/mL). The ROS generation in the worms intensified by increased concentration of OEE. The study proves that Oscillatoria tenuis, NTAPD 02, can be considered an anti-proliferative alga against C. albicans invasions.
KMT2B-Related Dystonia in Indian Patients With Literature Review and Emphasis on Asian Cohort
Authors: Dhar Debjyoti , Holla Vikram V , Kumari Riyanka , Sriram Neeharika , Saini Jitender , Yadav Ravi , Pandey Akhilesh , Kamble Nitish , Muthusamy Babylakshmi , Pal Pramod Kumar
Published: June 2023

ObjectiveaaMutations in the KMT2B gene have been identified in patients previously diagnosed with idiopathic dystonia. Literature on KMT2B-related dystonia is sparse in the Indian and Asian populations.MethodsaaWe report seven patients with KMT2B-related dystonia studied prospectively from May 2021 to September 2022. Patients underwent deep clinical phenotyping and genetic testing by whole-exome sequencing (WES). A systematic literature search was performed to identify the spectrum of previously published KMT2B-related disorders in the Asian subcontinent.ResultsaaThe seven identified patients with KMT2B-related dystonia had a median age at onset of four years. The majority experienced onset in the lower limbs (n = 5, 71.4%), with generalization at a median duration of 2 years. All patients except one had complex phenotypes manifesting as facial dysmorphism (n = 4), microcephaly (n = 3), developmental delay (n = 3), and short stature (n = 1). Magnetic resonance imaging (MRI) abnormalities were present in four cases. WES revealed novel mutations in the KMT2B gene in all patients except one. Compared to the largest cohort of patients with KMT2B-related disorders, the Asian cohort, comprising 42 patients, had a lower prevalence of female patients, facial dysmorphism, microcephaly, intellectual disability, and MRI abnormalities. Protein-truncating variants were more prevalent than missense variants. While microcephaly and short stature were more common in patients with missense mutations, facial dysmorphism was more common in patients with truncating variants. Deep brain stimulation, performed in 17 patients, had satisfactory outcomes.ConclusionaaThis is the largest series of patients with KMT2B-related disorders from India, further expanding the clinico-genotypic spectrum. The extended Asian cohort emphasizes the unique attributes of this part of the world.
Rapid-Onset Dystonia and Parkinsonism in a Patient With Gaucher Disease
Authors: Hertz Ellen , Lopez Grisel , Lichtenberg Jens , Haubenberger Dietrich , Tayebi Nahid , Hallett Mark , Sidransky Ellen
Published: June 2023

Biallelic mutations in GBA1 cause the lysosomal storage disorder Gaucher disease, and carriers of GBA1 variants have an increased risk of Parkinson’s disease (PD). It is still unknown whether GBA1 variants are also associated with other movement disorders. We present the case of a woman with type 1 Gaucher disease who developed acute dystonia and parkinsonism at 35 years of age during a recombinant enzyme infusion treatment. She developed severe dystonia in all extremities and a bilateral pill-rolling tremor that did not respond to levodopa treatment. Despite the abrupt onset of symptoms, neither Sanger nor whole genome sequencing revealed pathogenic variants in ATP1A3 associated with rapid-onset dystonia-parkinsonism (RDP). Further examination showed hyposmia and presynaptic dopaminergic deficits in [18F]-DOPA PET, which are commonly seen in PD but not in RDP. This case extends the spectrum of movement disorders reported in patients with GBA1 mutations, suggesting an intertwined phenotype.
Multiplicity results for fractional Schrödinger-Kirchhoff systems involving critical nonlinearities
Authors: Fareh Soraya , Akrout Kamel , Ghanmi Abdeljabbar , Repovš Dušan D.
Published: June 2023

In this article, we study certain critical Schrödinger-Kirchhoff-type systems involving the fractional

p

p

-Laplace operator on a bounded domain. More precisely, using the properties of the associated functional energy on the Nehari manifold sets and exploiting the analysis of the fibering map, we establish the multiplicity of solutions for such systems.
An automated reading of semi-quantitative hemagglutination results in microplates: Micro-assay for plant lectins
Authors: Gulzar Haseena , Pervez Sidra , Nawaz Muhammad Asif , Ullah Rahim , Jan Tour , Kan Farhat Ali , Jan Asad , Zahoor Muhammad , Ali Essam A. , Umar Muhammad Naveed
Published: June 2023

An automated, qualitative and semi-quantitative micro-assay for the detection of plant lectins also known as phyto-agglutinins (glycoproteins; have exciting applications in medicines) is described as an alternative to conventional assays. The method developed in this work is based on hemagglutination (HA) assay that can simultaneously detect the presence and concentration (titer) of lectins in as many as 96 different samples without the aid of an expert eye. We used rice (Oryza sativa L.) seeds for making clarified lectin extracts and Arabic gum as positive control in phosphate buffer saline; the method is applicable to all kinds and parts of the plants. Rabbit red blood cells were used in order to carry out the HA assay in a miniaturized experiment using U-welled microplates (MPs). 25 µL of plant extract is sufficient to carry out HA micro-assay at incubation temperature of 38°C for 20 min. The method was standardized with an expert eye and automated by using MP reader. Moreover, a standard curve for the direct interpretation of lectin concentration is also developed by conversion of absorbance values into titer. The method described will save time, material, labor, and simplify the rapid semi-quantification of plant lectins.
Creative and Research Segments of European Humanism: Development of a Single Cultural Space
Authors: Onishchenko Olena , Kholodynska Svitlana , Muratova Iryna , Myropolska Yevheniia , Ternova Maryna
Published: June 2023

The relevance of the mentioned topic of research consists in the definition of the phenomenon “metamodernism”, which in modern humanitarian knowledge and in literary and artistic practice determines the need to distinguish and analyze “segments” of European humanism as means of in-depth reproduction. The main goal of this study, considering the creative and research potential of “segments” that contributed to the gradual layering of specific features of European humanism, is the reconstruction of “for” and “against” those processes that caused the development of a single cultural space. The basis of the methodological approach in this study is the principles of historicism with the assignment of analytical, comparative, and chronological approaches to the determination of a wide range of issues that are of significant importance in the context of the stated topic. The results obtained during the implementation of this research, and the conclusions formulated on their basis, are of significant importance in the context of determining the key trends in the recognition of the creative and searching tendencies of European humanism, which play an important role in the process of forming a single cultural space.
An Interview with Wei Ma on Audio Description Script Writing for Blind-Accessible Films in China
Authors: Deng Yunke , Ma Wei
Published: June 2023

Blind-accessible films offer blind and visually impaired individuals the opportunity of enjoying a cinematic experience alongside the rest of the audience. Wei Ma is a member of the China Film and Television Association of Higher Education Institutions. His book, How to Make Blind-accessible Films in China, provides an overview of the evolution of blind-accessible films in Europe and the United States, elaborates on the growth and development of blind-accessible films in China, and provides a comprehensive exploration of the theory behind audio description (AD) and AD script-writing methods for blind-accessible films. In this interview, Ma Wei elaborates on blind-accessible film AD script-writing skills from both practical and theoretical perspectives and discusses some creative rules, methods, and techniques in AD. This interview was conducted online in January 2022 and is based on the final interview transcript in Chinese, which Wei Ma confirmed in May 2022.
Out-of-plane uniaxial loading of paperboard: experimental procedure and evaluation
Authors: Robertsson Kristofer , Engqvist Jonas , Wallin Mathias , Ristinmaa Matti , Tryding Johan , Borgqvist Eric
Published: June 2023

Development of three-dimensional continuum models for paperboard is an active field and the need for reliable measurements to calibrate and validate such models is evident. An experimental device and protocol for cyclic out-of-plane loading is developed. This loading sequence is present during converting operations of paperboard. The experimental tests reveals that the commonly observed soft initial non-linear response during out-of-plane compression is a structural effect that stems from the surface roughness rather than being an inherent material behavior. A gluing procedure, used to perform cyclic out-of-plane loading, is mitigating the effect of the surface roughness. Several novel cyclic loading experiments are performed, alternating between compression and tension which indicates that fiber bonds are not recovered in compression after they have been broken through delamination. Measurements also show that the transition in compression and tension is continuous, hence the use of a switch function present in a number of constitutive continuum models for paperboard is deemed questionable.
Regulations for food packaging materials
Authors: Amirullah Nur Amalina , Samsudin Mohd Hafif , Norrrahim Mohd Nor Faiz , Ilyas Rushdan Ahmad , Nurazzi Norizan Mohd , Jenol Mohd Azwan , Hawanis Husain Siti Nor , Gunny A. A. N.
Published: June 2023

Food safety and quality are essential concerns for consumers worldwide. One way to ensure that the food we consume meets these standards is through proper food regulation. While there are various aspects of food regulation, one critical aspect is the regulations for food packaging materials. As such, this book chapter has been written to provide an in-depth overview of the regulations for food packaging materials in different continents, namely Asia, Europe, and America. The chapter delves into several countries in each continent, such as Malaysia, Japan, Australia, China, the United States, and South Africa, and discusses their specific food packaging regulations. This chapter also emphasizes the importance of considering the composition, migration properties, and potential for contamination of food packaging materials. It highlights the need for regulations to ensure that food packaging materials do not adversely affect the safety and quality of food products. In light of the evolving food packaging industry, the chapter further underscores the need for continuous evaluation and improvement of food packaging regulations. This is crucial to keep up with emerging risks and new technologies that may arise and impact the safety and quality of food.
LaNiIn1–x
Sn
x
and CeNiIn1–x
Sn
x
solid solutions at T = 870 K
Authors: Nychyporuk Galyna , Dominyuk Nataliya , Muts Ihor , Zelinskiy Anatoliy , Pöttgen Rainer , Zaremba Vasyl
Published: June 2023

The solid solutions LaNiIn1–x
Sn
x
and CeNiIn1–x
Sn
x
were studied by means of X-ray powder diffraction and EDX analyses in the full concentration range for samples annealed at T = 870 K. The limited solubility of the fourth component in the starting compounds with equiatomic composition, and the limits and the unit cell parameters of the solid solutions have been determined. The crystal structure of CeNiIn0.57Sn0.43 was refined from single-crystal X-ray diffraction data: ZrNiAl-type structure; hexagonal space group P

6
‾

$\overline{6}$

2m, a = 0.74213(10), c = 0.40825(8) nm, R
1 = 0.0155, wR
2 = 0.0303, 282 independent hkl reflections and 15 refined parameters. The existence ranges within the solid solutions are discussed.
El BIG DATA Y SU IMPLICACIÓN EN EL MARKETING
Authors: Zúñiga Freddy , Mora Poveda Diego Alejandro , Llerena Llerena William Vinicio
Published: June 2023

El uso manifiesto de las nuevas tecnologías en el contexto de la industria 4.0, hace relevante conocer las implicaciones del Big Data en el Marketing, es por este motivo que la razón de ser del presente artículo es analizar diversa información con un enfoque cualitativo en un aspecto descriptivo y crítico. Con el fin de comprender la relevancia del Big Data en la actualidad. Para este trabajo se recolectó artículos publicados en diversas bases de datos científicas, con afán de darnos una visión referencial en un contexto más amplio sobre las ventajas, importancia y ciertas desventajas del Big Data. Haciendo énfasis en su implicación actual y a futuro de gran impacto en el mundo empresarial, para que de esta manera las empresas se sigan adaptando a las tecnologías 4.0. Reto que es importante hacer hincapié desde el punto de vista del Marketing, ya que el tratamiento de los datos será la base para el desarrollo de información, fundamental para la toma de acciones y decisiones, permitiendo personalizar la comunicación con nuestros clientes y de esta manera tener clientes más satisfechos y fieles con base en sus propias necesidades y deseos, brindando la oportunidad de cumplir las expectativas en los niveles más altos posibles e incluso no antes vistos.
CONTRIBUIÇÃO PARA A ACESSIBILIDADE E MOBILIDADE EM VEÍCULOS
Authors: Bentes Flávio Maldonado , Maia Júnior Álvaro Pereira , Velasque Robson Thiago Elias C.
Published: June 2023

Adaptações veiculares podem ser entendidas como equipamentos de segurança, desenvolvidos e projetados para auxiliar o deslocamento de pessoas com deficiência e/ou mobilidade reduzida, suprindo eventuais limitações físicas e motoras do condutor ou conduzido, promovendo a acessibilidade. O presente estudo buscou caracterizar um tipo de adaptação veicular para pessoas com mobilidade reduzida, realizada de maneira artesanal em uma minivan, utilizando um conjunto de estruturas metálicas que podem ser adaptadas em outros veículos automotores, dadas as devidas proporções. Esta adaptação se torna relevante à medida que descreve uma estrutura voltada para as necessidades específicas da pessoa com deficiência, com custos reduzidos em relação aos veículos adaptados comercialmente. Este estudo se caracteriza como uma pesquisa exploratória e apresenta como percurso metodológico um estudo de caso. A utilização desta estrutura pela família do deficiente, impactou não só na economia com custos adicionais relacionados a aquisição de um veículo que pudesse atender as necessidades específicas do conduzido, como na qualidade de vida da condutora, principalmente associada ao deslocamento e posicionamento do indivíduo no veículo. É importante salientar que o estudo apresenta possibilidades de ampliação e modificações em outros modelos automotores, impactando na qualidade de vida dos indivíduos e representando novas possibilidades de pesquisa na área de acessibilidade.
Molecular testing raises thyroid nodule fine needle aspiration diagnostic value
Authors: Han Dongyan , Ding Min , Xie Rongli , Wang Zhengshi , Xiao Guohui , Wang Xiaohong , Dong Lei , Yin Zhiqiang , Fei Jian
Published: June 2023

Thyroid fine needle aspiration biopsy (FNAB) remains indeterminate in 16–24% of the cases. Molecular testing could improve the diagnostic accuracy of FNAB. This study examined the gene mutation profile of patients with thyroid nodules and analyzed the diagnostic ability of molecular testing for thyroid nodules using a self-developed 18-gene test. Between January 2019 and August 2021, 513 samples (414 FNABs and 99 formalin-fixed paraffin-embedded (FFPE) specimens) underwent molecular testing at Ruijin Hospital. Sensitivity (Sen), specificity (Spe), positive predictive value (PPV), negative predictive value (NPV), and accuracy were calculated. There were 457 mutations in 428 samples. The rates of BRAF, RAS, TERT promoter, RET/PTC, and NTRK3 fusion mutations were 73.3% (n = 335), 9.6% (n = 44), 2.8% (n = 13), 4.8% (n = 22), and 0.4% (n = 2), respectively. The diagnostic ability of cytology and molecular testing were evaluated in Bethesda II and V–VI samples. For cytology alone, Sen, Spe, PPV, NPV, and accuracy were 100%, 25.0%, 97.4%, 100%, and 97.4%; these numbers were 87.5%, 50.0%, 98.0%, 12.5%, and 86.2% when considering positive mutation, and 87.5%, 75.0%, 99.0%, 17.6%, and 87.1% when considering positive cytology or and positive mutation. In Bethesda III–IV nodules, when relying solely on the presence of pathogenic mutations for diagnosis, Sen, Spe, PPV, NPV, and AC were 76.2%, 66.7%, 94.1%, 26.8%, and 75.0%, respectively. It might be necessary to analyze the molecular mechanisms of disease development at the genetic level to predict patients with malignant nodules more accurately in different risk strata and develop rational treatment strategies and definite management plans.
Ökonomisch und ökologisch effiziente Transformation von Produktionsnetzwerken in der Stahlindustrie
Authors: Weckenborg Christian , Graupner Yannik , Thies Christian , Meyer Christoph , Molzberger Mike , Vogeler Udo , Oppermann Jan , Spengler Thomas S.
Published: June 2023

Stahlproduzenten stehen vor der Herausforderung eine zugleich wirtschaftliche und klimafreundliche Stahlproduktion zu erreichen. Die Evaluation der möglichen technologischen Transformationspfade ist komplex. Wir entwickeln einen Ansatz zur Evaluation strategischer Entscheidungen zur Transformation von Produktionsnetzwerken in der Stahlindustrie.
Nutzung von Data Science Plattformen im Controlling
Authors: Huydts Alessandra P.C. , Möller Klaus , Weiser Michael J.
Published: June 2023

Da Unternehmen immer digitaler und datenzentrierter werden, stellt sich die Frage, welche Data Science Tools diesen Übergang am besten unterstützen. Für die Zwecke des Controllings eignen sich insbesondere Automatisierungsplattformen und kollaborative Data Science Plattformen, zu denen der Beitrag einen Überblick liefert.
Der Controller im Data Science Workflow
Authors: Gayk Daniel , Mauritz Christoph
Published: June 2023

Die Nutzung von Daten durch Methoden des maschinellen Lernens ist mit zahlreichen Implikationen für Controller verbunden. Anhand des CRISP-DM Prozessmodells und eines Anwendungsbeispiels aus der Praxis wird die Relevanz und Rolle von Controllern im Data Science Workflow aufgezeigt. Controller sind mit ihren Kernkompetenzen weiterhin sehr bedeutsam, müssen sich aber auch weiterentwickeln.
Predictive Analytics im Controlling
Authors: Exler Markus W. , Situm Mario , Störzer Dominic
Published: June 2023

Die Wichtigkeit von Prognosen für die zukünftige Unternehmensführung ist aufgrund sich schneller verändernden Umwelt- und Umfeldbedingungen unbestritten. Der Einsatz von Predictive Analytics (PA) kann hierbei unterstützen. Ausgehend von einer empirischen Erhebung wird dargestellt, welchen Mehrwert PA für Unternehmen hat, wie ein Prozess der Implementierung aussehen kann, welche Integrationsbreite und -tiefe man dabei umsetzen sollte und welchen Mehrwert externe Berater bei der Implementierung haben können.
Phenotypic correlations among wood properties and growth in wild cherry plantations
Authors: Nocetti Michela , Brunetti Michele , Ducci Fulvio , Romagnoli Manuela , Rozenberg Philippe , Santi Frédérique
Published: June 2023

Italy is one of the major users of cherry wood (Prunus avium L.), and its cultivation has been increasing since the early nineties, together with studies aimed at improving genotypes, with a selection usually based on growth, stem form, vigor, and tree adaptation. Here, the phenotypic correlations between growth rate and the physical and mechanical properties of wood are investigated in two wild cherry plantations. X-ray microdensitometry was also applied to analyze the age-age correlations of wood density. It was shown that growth rate did not affect wood properties, and density was confirmed to be the trait that best represents the main properties of wood. The absence of relationships between wood density and growth rate was confirmed by densitometric analysis, although an increase of wood density with an increase of ring width was detected for very narrow rings (less than 3 mm wide). The average density at age 7 to 8 was observed to be highly correlated (r > 0.90) to the average density of a 19-year-old tree, allowing reliable estimation of the wood properties of older trees by early investigation of young trees.