bluuebunny/crossref_metadata_2025 huggingface dataset:
Diacerein- A gold standard analgesic in management of osteoarthritis
Authors: N Yoganarasimha
Published: February 2020

Diacerein is a symptomatic slow-acting drug in osteoarthritis (SYSADOA) with anti-inflammatory, reconstructive and anti-destructive properties on cartilage and synovial membrane. Recently, based upon its mechanism of action it has been shown that it has got pro-anabolic effect on subchondral bone remodelling. Based on a literature review of clinical trials and meta-analyses, the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) declares that after the first month of osteoarthritic treatment the diacerein efficacy is superior to that of paracetamol and similar to that of non-steroidal anti-inflammatory drugs (NSAIDs). Additionally, once treatment was stopped diacerein has shown a prolonged effect on symptoms for several months, in view of its cumulative effects. Furthermore, similarly to other Symptomatic slow-acting drugs for OA (SYSADOAs), the ESCEO positions diacerein as a first-line pharmacological background treatment of osteoarthritis, particularly for patients in whom NSAIDs or paracetamol are contraindicated.
Comparison of changes in haemodynamic parameters in hypertensive patients after laryngoscopic endotracheal intubation or laryngeal mask airway insertion
Authors: Vijayarahavan N , P Mahilamani P , Paramasivan A
Published: February 2020

The hemodynamic response associated with laryngoscopy and tracheal intubation may be harmful to certain patients. The laryngeal mask airway avoids the need for laryngoscopy in appropriate patients.

: This study compares the changes in haemodynamic parameters in hypertensive patients after laryngoscopic endotracheal intubation or laryngeal mask airway insertion.

60 Hypertensive patients between 40 to 60 years ASA Grade II were randomly allotted to one of the groups of 30 each, group ET and group LMA. LMA insertion or tracheal intubation was performed after induction of anesthesia with Propofol and succinyl choline. The heart rate, mean arterial pressure and rate pressure product were measured after induction and immediately after insertion / intubation and then after 1, 3, 5 minutes.

There was very highly significant difference (p < 0.000) in mean increase in heart rate (38.23% in group ET versus 28.26% in group LMA). The increase in arterial pressure were also significant. The systolic BP increased 40.16% in group ET compared with 37.60% in group LMA (p< 0.000). The diastolic BP was also seen increasing by 22.73% and 14.23% in group ET and group LMA respectively. The MAP and RPP values were maximum after airway instrumentation however we found that values after LMA insertion were significantly lower when compared to tracheal intubation for the first 3 minutes.

LMA insertion in comparison to laryngoscopy and intubation is advantageous over tracheal intubation in hypertensive patients avoidance of pressure response.
Injection with long chain triglyceride or long chain triglyceride/medium chain triglyceride propofol: Which is less painful?
Authors: F Maliwad Jyotsna , B Parmar Pankajkumar , K Dave Jaydev , S Shringarpure Kalpita , D Damor Raman
Published: February 2020

: Long chain triglyceride/Medium chain triglyceride (LCT/MCT) Propofol 1% suspension is a new formulation having 10% fat emulsion consisting of long chain triglycerides (LCT) and medium-chain triglycerides (MCT). The pharmacokinetics and efficacy are similar to the standard Propofol LCT.

To compare incidence, intensity of pain on injection and hemodynamic stability with both 1% Propofol -LCT and 1% Propofol-LCT/MCT in patients undergoing surgery with general anaesthesia.

: This was a comparative study conducted in Shri M.P. Shah Medical College and Guru Gobind Hospital, Jamnagar. After due ethical clearances, 60 patients were divided into L group and L/M group by using random number table after taking written informed consent. The L-Group received 1% propofol-LCT while the L/M group received 1% propofol-LCT/MCT. After induction, pain was assessed using Verbal Rating Score for incidence and intensity of pain.

In L-group, 29 (96.67%) patients complained of pain, while in L/M-group 24 (80%) patients perceived pain. Ten (33.3%) patients in L group and 18 (60%) in L/M group had none to mild pain, but moderate to severe pain was perceived by 20 (66.67%) patients in L group compare d to 12(40%) in L/M group. The incidence of pain and intensity of pain on injection was greater in group L (p=0.04 and 0.03 respectively).

: Propofol-LCT/MCT may be considered in place of propofol-LCT as an anaesthetic agent since it reduces pain of injection.
A randomized comparative study of Airtraq®, McCoy and Macintosh laryngoscopes for endotracheal intubation in patients with simulated difficult airway using a rigid cervical neck collar in elective surgeries under general anaesthesia
Authors: Haridas Arjun , Babu T Raghavendra , C L Gurudatt
Published: February 2020

Laryngoscopy in patients with suspected neck injuries has one goal: sufficient laryngeal exposure with least cervical spine movement. This is achieved by either Manual In-line Stabilisation (MILS), a forehead tape or rigid cervical collars. Cervical collars reduce movements of spine and also mouth opening leading to difficult direct laryngoscopy. This is due to difficulty in aligning the oro-pharyngo-laryngeal axes. The laryngoscope giving best glottic view with least cervical spine movement in the shortest time would be most ideal. We intend to compare Airtraq, McCoy and Macintosh laryngoscopes in terms of intubation time and Cormack-Lehane glottic view in patients undergoing elective surgeries with simulated neck immobilization using rigid cervical collar.

: Following approval from Institutional Ethical Committee, 90 consenting patients, aged 18-65years were assigned into three groups by random sampling (Serially numbered Opaque Sealed Envelope), namely Group A (Airtraq), M (McCoy) or C (Macintosh). Intubation time, Intubation difficulty scale (IDS) and Modified Cormack-Lehane grading were noted.

: Mean intubation time was 27.2sec(± 6.47), 40.2sec (± 12.36) and 33.10sec (± 23.05) for Airtraq, McCoy and Macintosh respectively(p-value 0.00 7). IDS values were 0,3 and 2 respectively(P< 0.0001). Cormack Lehane glottic view was 2 for Macintosh and McCoy and 1 for Airtraq, respectively (P< 0.0001).

Airtraq improves ease of intubation significantly when compared to McCoy and Macintosh blade with shorter intubation time and IDS Score, in patients with simulated difficult airway using neck immobilization.
To evaluate efficacy and safety of diclofenac transdermal patch with intramuscular diclofenac injection as preemptive analgesia in post operative patients undergoing inguinal hernioplasty
Authors: Kishor Kabir Kaushal , Banjare Manish , Agarwal Arpit , K Arora K
Published: February 2020

To evaluate efficacy and safety of diclofenac transdermal patch with intramuscular diclofenac injection as preemptive analgesia in post operative patients undergoing inguinal hernioplasty.

: We aim to compare the duration and quality of analgesia provided by diclofenac trans dermal patch and intramuscular injection and to estimate time at which patients demand rescue analgesia after surgery.

: This randomized comparative study was conducted at a tertiary care hospital in central India.

: 60 healthy patients divided into two groups of 30 each, scheduled for elective inguinal hernioplasty under subarachnoid block were taken. Sample size calculation was based on the difference of means of two independent samples. A transdermal diclofenac patch containing 100 mg of diclofenac diethylamine was applied to the participants in the study group just before the induction of anesthesia. In the control group, 75 mg of diclofenac sodium Inj. was given intramuscularly half-an-hour before the end of surgery.

Data for postoperative pain was assessed at 2, 4, 6, 8, 12, 16 and 24 hours by using a visual analogue scale (VAS) score and verbal rating scale (VRS) score and analysed using upaired t test.

: Statistical difference in duration, quality of pre-emptive analgesia and Significant time of rescue analgesia was found between the two groups in terms of postoperative pain in patients undergoing inguinal hernioplasty.

Tran dermal diclofenac patch (100 mg) is a better analgesic route than intramuscular diclofenac sodium (75 mg) for pre-emptive analgesia in patients undergoing inguinal hernioplasty.
Ropivacaine vs ropivacaine with morphine after arthroscopic surgery – A study of analgesic efficacy
Authors: Jain Prithi , Shetty Kishan , M Saldanha Nichelle , Dionel Dsouza Ashton
Published: February 2020

Multimodal anaesthesia is recommended for treatment of postoperative pain. The rationale behind this is to attain sufficient analgesia due to the synergistic and additive between various analgesics with concomitant reduction in dose of any individual drug required to attain the same effect. Therefore a combination of Ropivacaine with Morphine intra-articular was hypothesized to have better and longer postoperative analgesic effects as compared to Ropivacaine alone.

Knee arthroscopies are being performed more and more often as day care surgeries under regional anaesthesia hence there is a need for suitable postoperative analgesia regimen with a long duration of action, good safety profile and which provides the ability for the patient to ambulate.

This study was undertaken to compare the effects of intra-articular Ropivacaine with the effects of a combination of intra-articular Ropivacaine and Morphine. 60 patients were divided into two groups of 30 each, one receiving Ropivacaine and the other the combination of Ropivacaine and Morphine.

In this study we found that post-operative pain was less in the group receiving the combination of intra-articular Ropivacaine and Morphine. The need for rescue analgesics was also found to be less in the group receiving the combination of intra-articular Ropivacaine and Morphine.
A comparison of intrathecal low dose Dexmedetomidine and clonidine as an adjuvant to bupivacaine in patients undergoing gynecological surgeries
Authors: Dave Smitul , V Bhatia Upasna , Rafikbhai Hudda Renish
Published: February 2020

: In the anquity of post-operative analgesia, the inception of α-2 adrenergic agonist agents in subarachnoid space with adjuvance to bupivacaine has opened new chapter.

The intent of the study was to compare the onset of duration of sensory and motor block, hemodynamic effects, post-operative analgesia and adverse effects of dexmedetomidine and clonidine with hyperbaric 0.5% bupivacaine for spinal anaesthesia.

: Sixty adult patients received subarachnoid block either with Injection Bupivacaine (15mg) with clonidine (30µg) or Injection Bupivacaine (15mg) with Dex medetomidine (10µg). Patients were monitored for variations in heart rate and noninvasive blood pressure after the spinal anaesthesia was given till the surgery got over every 5 minutes. Both the groups were compared for onset time for sensory block, time to reach sensory block to T and T level, time of regression of sensory block by 2 dermatomes and duration of analgesia.

: Mean Onset time of sensory block, time to reach T and T level was greater but not significant in Dexmedetomidine group but regression time of sensory block by 2 dermatomes was significantly higher in clonidine group, 100.21±2.58 minutes as compared to 80.43±3.45 in dexmedetomidine group. Onset time to reach bromage II was significantly faster in group BD (35.53 ±3.57seconds) as compared to Clonidine group (49.03 ± 30.15seconds). Dexmedetomidine group patients had significantly (p<0.0001) higher duration of analgesia (589 ± 5.5minutes) as compared to Group clonidine (507 ± 4.8minutes). There was no sedation and no hemodynamic instability observed in either of the groups.

We conclude that though both Clonidine and Dexmedetomidine prolongs duration of sensory and motor block of Bupivacaine, But Dexmedetomidine is more appropriate as it provides better VAS score (quality) and longer duration of postoperative analgesia than clonidine.
Efficacy of preoperative melatonin and ramelteon (melatonin agonist) therapy on dose requirement of propofol for induction of general anaesthesia: A comparative prospective study
Authors: Panigrahi Manas Ranjan , Roy Kuntal , Mukhopadhyay Bhabananda , Bisak Santanu , Binay Kumar
Published: February 2020

General anesthesia is a medically induced coma with loss of protective reflexes resulting from the administration of one or more general anesthetic agents our study is to compare the role and efficacy of preoperative oral Melatonin, Ramelteon, and Midazolam therapy on the dose requirement of induction agent (Propofol).

: Were divided into Case and Control Group. Case group of people were given Oral Melatonin (6mg)/Ramelteon (8mg) as premedication 2 to 3 hours before induction in OT and the control group were given oral Midazolam (5mg). After checking all the parameters, the induction process Total number of 60 people was randomly selected from ASA grade I & grade II, aged between 20 to 50 years, started with injection Propofol slowly in intravenous route and subsequently the BIS level up 60 was noted. After complete reversal of General Anesthesia, post-operative sedation level of the patient was measured using Ramsey sedation scale.

Melatonin and Ramelteon shows significant reduction in preoperative anxiety state of the patient in comparison to Midazolam, measured by Hamilton Anxiety rating scale. The sedation status was measured by Ramsey Sedation Scale for each drug and it shows no significant difference between the drugs.

: Considering absolute values and statistical values, all three drugs are potent premedication in general anesthesia. Among them, Melatonin is most potent in reducing the induction dose of injection Propofol. Ramelteon is also effective in reducing induction dose of Propofol. Along with, both are potent anxiolytic agent in pre-operative state.
Oświeceni latarni się nie boją. Szkic polemiczny
Authors: Skórczewski Dariusz
Published: March 2020

Autor podejmuje polemikę z tezami Grzegorza Zająca, wyłożonymi w artykule Oświeconych nie trzeba oświecać – refleksje o szkole, powadze czytania i szaleństwie ideologii („Roczniki Humanistyczne” 67(2019), z. 1, s. 25-38). Polemika dotyczy rzekomego ideologicznego redukcjonizmu interpretacyjnego i instrumentalizacji literatury we współczesnej, postmodernistycznej nauce o literaturze ze względu na jej podatność na ideologizację. Podczas gdy G. Zając opowiada się za powrotem do lektury nastawionej na jakości estetyczne literatury jako sztuki, sytuując się na pozycji sprzed „upadku” dyskursu literaturoznawczego, autor artykułu proponuje uznanie tego „upadku” za fakt i skonfrontowanie się z krajobrazem „po upadku”. W konfrontacji tej, mającej skłonić do dyskusji nad różnymi zestawami wartości, leżącymi u podstaw poszczególnych nurtów współczesnych badań literackich, istotną rolę zdaniem autora może odegrać rozumiana po neoarystotelesowsku „Tradycja”, którą w swojej przełomowej książce Trzy antagonistyczne wersje dociekań moralnych Alasdair MacIntyre przeciwstawia modernistycznej „Encyklopedii” i postmodernistycznej „Genealogii”.
Jana Polkowskiego wiersze-rozmowy z Herbertem i Różewiczem
Authors: Kudyba Wojciech
Published: March 2020

Poezję Jana Polkowskiego łączy z Herbertem wspólny obu poetom program poezji etycznej, charakterystyczną właśnie dla nich pasję przyświadczania podstawowym wartościom i wiarę w ocalającą moc kultury. Ciekawą grę intertekstualną, zainicjowaną przez młodszego pisarza w wierszu Przesłanie pana X, pozwala jednak niuansować ten uproszczony obraz. Od początku Przesłania pana X jest jasne, że nadzieja, której Polkowski nie odrzuca, wydaje się w jego tekście dużo bardziej problematyczna niż wizja zamieszkania w mitach kultury, jaka wyłania się z utworu autora Potęgi smaku. Także obraz wyraźnego antagonizmu Polkowskiego i Różewicza musi ulec weryfikacji. Polkowski jako autor Rozmów z Różewiczem daje się wciągnąć starszym kolegom po piórze właśnie do rozmowy − o poezji i jej zadaniach, zarysowując nie tylko protokół rozbieżności, ale także szukając tego, co jest mu bliskie w twórczości autora Niepokoju.
Acretismo diagnóstico prenatal mediante ultrasonido y resonancia magnética y su correlación histopatológica en Barranquilla (Colombia)
Authors: Parra-Anaya Guido , Díaz-Yunez Israel , Serrano-Montes Saray , Vergara-Quintero Felipe , De Nubbila-Lizcano Eduardo
Published: March 2020

Introducción: el acretismo y percretismo se asocian con antecedentes de placentas previas y cesáreas anteriores, las cuales se han incrementado en nuestro medio. Por este motivo, su detección anteparto es fundamental en el propósito de disminuir el riesgo de morbimortalidad materna.Objetivo: evaluar la utilidad del ultrasonido (US) y la resonancia magnética (RM) en el diagnóstico prenatal de este trastorno adherencial placentario.Metodología: el presente es un estudio de cohorte prospectivo que incluyó a once mujeres en tercer trimestre de embarazo con antecedentes de placenta previa y cesárea anterior, a las cuales se les practicó US transabdominal y transvaginal, Doppler color y resonancia magnética, buscando signos de acretismo, los cuales fueron comparados con los hallazgos durante el parto y la histopatología.Resultados: el ultrasonido mostró una sensibilidad de 70% (IC95% 35,4-91,9). En contraste, el Doppler color y la resonancia magnética evidenciaron una sensibilidad de 90% (IC 95% 54,1-99,5).Conclusión: en pacientes con placenta previa y cesárea anterior, el US y el Doppler color surgen como una herramienta útil en la detección de acretismo placentario; sin embargo, se requieren mayores estudios para confirmar su validez diagnóstica.
Tenofovir plus entecavir combination therapy for chronic hepatitis B with nucleos(t)ide analogue failure
Authors: TATAR Bengü , KÖSE Şükran
Published: February 2020

Objectives: Currently, both entecavir (ETV) and tenofovir (TDF) are recommended ﬁrst-line therapy for chronic hepatitis B treatment due to good tolerance, lower side-effect profile and high genetic barrier. However, mutations that may develop in the polymerase gene during treatment may result treatment failure. In this study, we aimed to evaluate the efficacy and virologic response of ETV plus TDF combination therapy in chronic hepatitis B patients with suboptimal response to nucleos(t)ide analogues (NAs) monotherapy. Methods: A total of 813 patients who were followed-up with the diagnosis of chronic hepatitis B and who were treated with TDF or ETV monotherapy were screened. Patients who had a partial or non response to monotherapy during at least 12 months and who was the presence of serum HBV-DNA levels ≥ 2000 IU/mL at the time of initiation of the ETV plus TDF combination therapy were included. Results: Ten (1.2%) patients (9 TDF, 1 ETV) were identiﬁed to have had partial response (50%) or breaktrough (40%) or virologic rebound (10%) to monotherapy. The median age was 36.8 years (range, 22-55 years), and 5/10 (50%) patients were male. Of 10 patients, nine of achieved undetectable HBV-DNA (< 15 IU/mL) levels (50% of in 6 months and 90% of in 18 months) with combination therapy. One patient showed no response. Conclusions: Our results suggest that combination therapy is superior to the antiviral change in treatment failure with NAs. In addition, it is important to conduct HBV drug resistance analyzes to prevent false drug change in treatment.
VITAMIN D NEPHROPROTECTIVE STRATEGY OF CHILDREN WITH CHRONIC RENAL DISEASE
Authors: Semin Sergey G. , Kolbe O. B , Moiseev A. B , Turchinskaya A. I , Vartapetova E. E
Published: March 2020

According to current conception, the process of forming of nephrosclerosis despite the origins is detected by the force of the same cellular and molecular mechanisms. Hence primary triggers cause elevated production of range of cellular response mediators, cytokines and growth factors such as transforming plateled-derived growth factor, fibroblast growth factor, interferon gamma, nuclear factor and others, by means of sequential processes, is followed by the replacement of kidney tissue. One of the most studied aspects of the process of nephrosclerosis is the influence of anginotensin II. Therefore, despite the triggering factors, development and progression of nephrosclerosis all children with chronic renal disease are in a risk group with predisposition for renal insufficiency and it is required to prescribe nephroprotective therapy, i.e. the drugs that will influence one of the links of the nephrosclerosis, in order to slow down its progression. Currently, with nephroprotective goal in early age are used the following elements - angiotensin converting enzyme inhibitors and angiotensin receptors, antogonists (blockers). Lately, the active search for effective and safe drugs with nephroprotective effect on one side and great interest towards undiscovered before qualities of Vitamin D caused a huge amount of works that support the effect of Vitamin D. Prescription of Vitamin D to animals with uremia was followed by the drop of apoptosis of podocides and loss of the protein that is contained in the split diaphragm that caused decrease in proteinuria. Vitamin D suppresses protophibrotic TGF-B1 in tubular epithelial cells. The regression of tubulointerstitial phibrosis under the influence of Vitamin D was confirmed based on the cases of animals with obstruction of urethra. Along with the use of the mentioned above groups of drugs, which effectiveness was proved experimentally and clinically, we strongly believe the more thorough study of the Vitamin D drug use is needed, especially to study the prevention and slowing down of the progression of nephrosclerosis in the cases of children with chronic renal disease. It is crucial to detect the exact dosage of the drug, the prescription period and the methods for the control of the effective concentration of the drug.
AGE PECULIARITIES OF COLORECTAL CANCER INCIDENCE IN THE REPUBLIC OF BASHKORTOSTAN
Authors: Pavlova M. Yu. , Dautova L. P , Sharafutdinova Nazira Kh. , Sultanov R. Z
Published: March 2020

In the Russian Federation in recent years, there has been an increase in the incidence of colorectal cancer. The probability of the disease with colorectal cancer increases after 40 years and sharply increases after 50 years. Aim. To study the age-specific features of the prevalence of colorectal cancer in the Republic of Bashkortostan. Materials and methods. As the research materials, the form of Federal statistical observation No. 7 “Information on the incidence of malignant neoplasms” was used in the Republic of Bashkortostan for 2008-2016. The indicators of the incidence of colorectal and rectum cancer per 100 thousand of the population, depending on age and sex, are calculated. Results and discussion. The lowest incidence of colorectal cancer was observed in the age group up to 30 years, the largest - at the age of 70 years and older. For the years 2008-2016 the proportion of patients younger than 50 years with newly diagnosed colon cancer increased from 8.1% to 9.0% and rectum from 7.2% to 8.1%. In this age group there was an increase in primary incidence of colorectal cancer among men by 84.0%, among women by 50.0%, rectal cancer by 54.2% and 68.0%, respectively. The decrease in the incidence of colorectal cancer in the age group of 70 years and older. The average annual incidence rate of colorectal cancer was higher among men than among women in the age groups 50-59, 60-69 years and 70 years and older, rectal cancer in all age groups, with differences increasing with age. During the observation period, the mean age of patients with newly diagnosed colon cancer was reduced by 1.5 years, rectal by 1.3 years. Among patients with colorectal cancer living in urban areas, the average age was higher than in rural areas. The conclusion. The revealed sex-age features of the prevalence of colorectal cancer were used in the development of measures to improve medical care for patients.
CONSEQUENCES OF RADIATION THERAPY OF ONCOLOGICAL DISEASES: FOCUS ON PERICARDITIS
Authors: Emelina E. I , Ibragimova A. A , Dreval P. A , Gendlin Gennady E. , Nikitin I. G , Byalik I. E , Antuch E. A
Published: March 2020

Radiation exposure of the chest is associated with a significant risk of subsequent development of cardiovascular diseases. Associated cardiovascular injuries include pericardial disease, coronary artery disease, valvular disease, conduction disease, cardiomyopathy, and vasculopathy. This article presents the development of different variants of pericardial radiation damage, methods of diagnosis and treatment of these complications. Radiation damage to the pericardium can manifest as acute pericarditis, effusion with tamponade or without cardiac tamponade, effusion-constrictive or classic constrictive pericarditis. Algorithms for the diagnosis and treatment of patients with radiation pericarditis in connection with a long asymptomatic course in a number of patients deserve special attention. Careful history taking and identifying prior radiotherapy is important in this category of patients. Untimely diagnosis and late treatment of these complications leads to a decrease in the quality of life of patients and increases the risk of cardiovascular mortality.
DIRECT ORAL ANTICOAGULANTS: A COMPARISON OF EFFICACY AND SAFETY, ERRORS IN THEIR APPLICATION, AND THE USAGE OF REVERSAL AGENTS
Authors: Tarasov V. V , Chubarev Vladimir N. , Zykova E. S , Belosludtsev A. S , Mokshanova E. G , Sologova S. S , Lebedeva S. A , Grigorevskikh E. M , Zatsepilova T. A , Preferanskaya N. G , Musina N. Z , Sologova D. I
Published: March 2020

This review is devoted to updating the existing knowledge about pharmacology of the drugs from the group of direct oral anticoagulants (DOACs). Special attention is paid to comparison of the anticoagulant properties of DOACs with traditional (indirect) anticoagulants at various dosage regimens and to study drug interactions of DOACs with drugs from different pharmacological groups. Widely analyzed the side effects associated with errors in the application of DOACs and provided recommendations for their correction, including the using of reversal agents therapy. Based on this, the presented article will be useful to clinicians to familiarize themselves with modern medical strategies based on the use of drugs from the DOACs group for the prevention and treatment of diseases associated with increased blood clotting ability and using of DOACs specific antagonists for treatment overdose of DOACs.
SOCIO-HYGIENIC CHARACTERISTICS OF WOMEN OF REPRODUCTIVE AGE AND ITS ROLE IN THE DEVELOPMENT OF GYNECOLOGIC PATHOLOGY
Authors: Turbina Yu. O , Polunina N. V , Polunin Valery S.
Published: March 2020

In the structure of general morbidity in Russia for 2018 year of complications of pregnancy and childbirth took place and 3 tend to grow. Aim - study of socio-sanitary characteristics and reproductive behaviour of women of childbearing age (ZhFV) and determining their impact on women’s health. Materials and methods: data from medical records and questioning women in 2017 year in Moscow. The results. Provided social and hygienic characteristics of observed women, average age of 32 years, two thirds, a quarter of workers are housewives, every tenth-student, 66% are married, 82% regularly visit a physician, each the fifth has gynecological disease, 70% believe contraception necessary, 62% are related to abortion adversely. Conclusion. It is advisable to generate a high level of medical activity in women, as the future of the mind, from school age, to carry out sex education with a focus on healthy lifestyle, paying attention towards abortion and sexual partner the family as a whole.
POTENTIAL FOR RESTORATIVE TREATMENT OF PATIENTS WITH MYOFASCIAL PAIN SYNDROME WITH THE USE OF OSTEOPATHY AND SHOCKWAVE THERAPY
Authors: Zuev Denis S. , Kostenko E. V
Published: March 2020

Introduction. Complex investigation of rehabilitation treatment possibilities in patients with Myofascial pain syndrome using osteopathy and extracorporeal shock wave therapy (ESWT) remains a very actual problem. Materials and methods. 120 patients with myofascial pain syndrome at the age of 49,65±0,89 years old were investigated. The average duration of the disease - 2,29±0,18 years. Results. Combination of standard therapy with osteopathic treatments and ESWT decreases severity of Myofascial pain syndrome measured with five-point vertebro-neurological symptoms scale after 12 months of observations for 59,2%. Standard therapy together with osteopathic treatment reduces severity of Myofascial pain syndrome for 43,3%. Standard therapy together with ESWT reduces severity of Myofascial pain syndrome for 34,2%. Standard therapy alone reduces severity of Myofascial pain syndrome for 31,6%. Dynamic of Visual analogue scale pain parameters was 77,1%, 62,2%, 52,8% and 30,9%, that was accompanied by The Oswestry Disability Index (ODI) average values decrease by 92,4%, 75,9%, 66,8% and 39,9%, respectively. Severity of Visual analogue scale symptoms were directly proportional to the parameters of IMS (r=0,231) and ODI (r=0,379), whereas the symptoms severity reduction level in this scale has strong correlation with the level of IMS scale dynamics (r=0,85). Conclusion. When forming the rehabilitation treatment Protocol of patients with myofascial pain syndrome using osteopathy and shock wave therapy one should consider that according to the 12-month prospective observation, it is the combination of these methods that shows the most positive effect on the severity of myofascial pain syndrome, measured with VAS scale, five-point vertebro-neurological symptoms evaluation scale and osvestri questionnaire.
La hermenéutica analógica en el campo de la filosofía
Authors: Beuchot Puente Mauricio Hardie
Published: March 2020

El presente artículo desarrolla un concepto de la filosofía y, a partir de este último, un concepto de la hermenéutica analógica. Presenta esta última como un instrumento de interpretación de textos filosóficos que evita caer en el univocismo propio de la perspectiva moderna y positivista, según la cual sólo hay una única interpretación válida, tanto como evita caer en el equivocismo de la perspectiva posmoderna y relativista, según la cual todas las interpretaciones son correctas. Muestra que la hermenéutica analógica no sólo se distingue de la unívoca y la equívoca, sino que también emplea las dos formas de la analogía conceptualizadas en la Edad Media, a saber, la analogía de proporcionalidad y la analogía de atribución. Finalmente, el artículo expone cómo la analogía de proporcionalidad es capaz de aglutinar, conmensurar o coordinar varias interpretaciones de un texto hallando lo que estas tienen en común, es decir, encontrando su común denominador a pesar de las diferencias que presentan entre sí.
Editorial
Authors: Diagama Briceño Camilo Andrés
Published: March 2020

El presente número de Cuestiones de filosofía contiene artículos de reflexión acerca de temas y problemas diversos. Esta diversidad hace difícil cualquierintento de clasificación, si se considera que los textos no sólo remiten a obras filosóficas de distintas épocas, sino también que se desarrollan desde perspectivasfilosóficas diferentes. El conjunto de los artículos muestra, en todo caso, que el pluralismo ha sido uno de los criterios principales de nuestra publicación.
Cuestiones de Filosofía Núm. 25 versión completa
Authors: Diagama Briceño Camilo Andrés
Published: March 2020

Cuestiones de Filosofía Núm. 25 versión completa
Aspectos ético-filosóficos de la muerte: entre la responsabilidad moral y la deshumanización
Authors: Correa Cetina Edwin Augusto
Published: March 2020

En tiempos pasados la transgresión a la norma que prohíbe asesinar a un ser humano estuvo amparada en creencias sobrenaturales; en tiempos hostiles la norma era levantada para dar lugar al sadismo connatural del ser humano, sin embargo han sido distintos los escenarios y las causas donde la muerte cobra protagonismo. Trazado en esta dirección, este texto, en su primera parte, explora el sentido espeluznante asignado a la muerte en tiempos arcaicos. Sumado a ello, aparece un diálogo y confrontación que mana de los conceptos de posibilidad-imposibilidad y continuidad-discontinuidad. En la segunda parte, se realiza una contextualización de la guerra y el exterminio como protagonistas dinamizadores de la crueldad, resaltándose la deshumanización y la herencia arcaica de la violencia como ejes que gravitan en torno a la destrucción corporal de un sin número subjetividades. En la tercera parte, se analiza la responsabilidad individual ante el abominable llamado del Gran Otro. Y a modo de cierre, se expone como el morir por el querer del Otro es legitimado por el Estado.
Genotypic Variation in Calcium Uptake in Common Bean (Phaseolus vulgaris L.) under Chilling Stress
Authors: DERE Sultan , DAŞGAN Yıldız , CEYLAN Elife , İLHAN Merve
Published: February 2020

Plants are constantly exposed to different abiotic stresses throughout their lifecycle. Sub-optimal temperatures areimportant abiotic stress factors in agriculture. Plant growth, development, yield, and crop quality are significantly affected bylow temperature stress. In the present study, 95 different common bean genotypes were grown in the growth chamber. As thecontrol group, the growth chamber was designed to be 16/8 h light and dark with 25 °C and 20 °C day/night temperatures,respectively. Fifteen days old seedlings were exposed to chilling stress as cold stress treatment in the dark (night) at 4 °C for8 hours and in light (day) at 25 oC for 16 hours. After fifteen days of low temperature stress, the experiment was completed toinvestigate calcium (Ca) intake in plants. Shoot Ca concentration of the genotypes were analyzed and genotypes wereclassified according to their Ca content. Therefore 24 genotypes were found to have less than ≤0.5%, 35 genotypes were foundto have between 0.51 to1.0% and 36 genotypes were found to have between 1.01 to 3.0% Ca content under chilling stress.
Timolipoma: Uma Radiografia Pouco Convencional
Authors: Rosa Duarte Miguel , Dos Santos Sofia Frade , Conceição e Silva João Paulo
Published: March 2020

N/D.
Capnothorax During Laparoscopy in Trendelenburg Position: A Rare Case Study
Authors: Damas Ana Margarida , Gonçalves Fátima , Antunes Marisa , Barata Sónia
Published: March 2020

Pneumothorax is an infrequent complication of laparoscopic surgery. Most cases occur during upper abdominal surgery, since a head-down position (Trendelenburg) pushes the liver and peritoneum against the diaphragm, reducing gas release. When it is due to CO2 diffusion across congenital diaphragmatic defects, it usually resolves itself spontaneously after de-insufflation of the pneumoperitoneum. Increasing positive end-expiratory pressure to counteract intra-abdominal pressure is an effective measure when a pulmonary origin is excluded. We report a case of right-sided hypertensive capnothorax due to a diaphragmatic defect, during lower abdominal surgery, which was successfully managed without the need for chest drainage. This case highlights the importance of maintaining active vigilance and a high index of suspicion for pneumothorax during laparoscopic surgery.
Enhancing patient safety and access to care to populations at risk of exclusion: the example of the Portuguese-speaking migrant community in South London
Authors: Figueiredo Cristiano , Silva Paula Maia da , Sharma Vikesh , Neves Ana Luísa
Published: March 2020

N/A.
Errata ao artigo “Papel do Tecido Adiposo e dos Macrófagos no Estado de Inflamação Crónica Associada à Obesidade - Implicações Clínicas”, publicado em Acta Med Port 2008; 21: 489-496
Authors: Santareno Sofia , Cerqueira Joao , Português Joao , Cruz Joana , Ramalho Renata , Guimarães Cristina
Published: March 2020

Na página 489, na linha de autoria, onde se lê: Renata RAMALHO, Cristina GUIMARÃES Deverá ler-se: Sofia SANTARENO, Joao CERQUEIRA, Joao PORTUGUÊS, Joana CRUZ, Renata RAMALHO, Cristina GUIMARÃESNa página 489, na coluna da direita onde se lê: R.R., C.G.: Serviço e Laboratório de Imunologia. Faculdade de Medicina da Universidade do Porto. Porto Deverá ler-se: S.S., J.C., J.P., J.C.: Faculdade de Medicina da Universidade do Porto. PortoR.R., C.G.: Serviço e Laboratório de Imunologia. Faculdade de Medicina da Universidade do Porto. PortoNos cabeçalhos das páginas 490, 491, 492, 493, 494 e 495, onde se lê: Renata RAMALHO et al, Papel do tecido adiposo e dos macrófagos no estado de inflamação..., Acta Med Port. 2008; 21(5):489-496 Deverá ler-se Sofia SANTARENO et al, Papel do tecido adiposo e dos macrófagos no estado de inflamação..., Acta Med Port. 2008; 21(5):489-496Artigo publicado com erros:https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1635
A New Approach to Expandable Structures: Crossed Expandable Frames (X-Frames)
Authors: Muñoz-Vidal M. , López César Isaac R. , Pérez-Valcárcel J. B. , Riestra F. Suárez
Published: February 2020

The use of expandable structures in the field of building began in the 1960s, based on the pioneering work of Emilio Pérez Piñero. They underwent significant developments at the end of the 20th century, with typologies based on scissors or bundle modules. Until
now, this typology has not been further enhanced, despite some very interesting contributions.
 These studies are usually based on straight bar expandable structures, although there are some interesting proposals based on the deployability of parallel arc systems, even in real buildings.
However, other possible types of expandable structures have not been explored to date.
 In this paper, a new system for expandable structures is proposed, which opens new and interesting design possibilities based on the same folding principle. The system consists of deploying elements
such as arches or frames with multiple intersections. Solutions for cylindrical vaults with horizontal axis joints and more complex geometries such as conoids are proposed, as well as domes with vertical and horizontal axis joints. Finally, other structures with special kinematic compatibility
difficulties, such as concentric domes or toroids, are also studied.
Systematic Review: The Impact of Socioeconomic Factors on Aedes aegypti Mosquito Distribution in the Mainland United States
Authors: Holeva-Eklund Whitney M. , Behrens Timothy K. , Hepp Crystal M.
Published: March 2020

Aedes aegypti mosquitoes are primary vectors of dengue, yellow fever, chikungunya and Zika viruses. Ae. aegypti is highly anthropophilic and relies nearly exclusively on human blood meals and habitats for reproduction. Socioeconomic factors may influence the spread of Ae. aegypti due to its close relationship with humans. This paper describes and summarizes the published literature on how socioeconomic variables influence the distribution of Ae. aegypti mosquitoes in the mainland United States. A comprehensive search of PubMed/Medline, Scopus, Web of Science, and EBSCO Academic Search Complete through June 12, 2019 was used to retrieve all articles published in English on the association of socioeconomic factors and the distribution of Ae. aegypti mosquitoes. Additionally, a hand search of mosquito control association websites was conducted in an attempt to identify relevant grey literature. Articles were screened for eligibility using the process described in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Initially, 3,493 articles were identified through the database searches and previously known literature. After checking for duplicates, 2,145 articles remained. 570 additional records were identified through the grey literature search for a total of 2,715 articles. These articles were screened for eligibility using their titles and abstracts, and 2,677 articles were excluded for not meeting the eligibility criteria. Finally, the full text for each of the remaining articles (n = 38) was read to determine eligibility. Through this screening process, 11 articles were identified for inclusion in this review. The findings for these 11 studies revealed inconsistent relationships between the studied socioeconomic factors and the distribution and abundance of Ae. aegypti. The findings of this review suggest a gap in the literature and understanding of the influence of anthropogenic factors on the distribution of Ae. aegypti that could hinder efforts to implement effective public health prevention and control strategies should a disease outbreak occur.
Effect of Precious Metals on NO Reduction by CO in Oxidative Conditions
Authors: Akil Joudia , Siffert Stephane , Laurence Pirault-Roy , Debecker Damien P. , Devred François , Cousin Renaud , Poupin Christophe
Published: March 2020

Carbon dioxide has become a global challenge, where the emissions have become more than what could be handled. In this regard, conversion of CO2 to value added chemicals and thus recycling CO2 became a viable option. One of these options is the use of a process in strong development: oxycombustion. However, the gases resulting from this process contain some traces of impurities that can hinder the recovery of CO2 such as NO and CO. This work has therefore focused on the study of the reaction of NO reduction by CO in an oxidizing medium, using catalytic materials based on various supported noble metals. These materials were extensively characterized by a variety of methods including BET surface area measurements, hydrogen chemisorption, Transmission Electron Microscopy (TEM) and H2 temperature programmed reduction (H2-TPR). The obtained results show that the catalytic behaviour of M/Al2O3 catalysts in CO oxidation and NO reduction with CO in oxidative conditions depends mainly on the nature of the metal. The best result for these both reactions is obtained with Pt/Al2O3 catalyst. The Pt nanoparticles existing in the metallic form (Pt°) showed by TPR could explain the activity.
Plant Density and Nitrogen Responses of Maize Hybrids in Diverse Agro-ecologies of West and Central Africa
Authors: Ajayo Babatope , Badu-Apraku Baffour , Fakorede Morakinyo , Akinwale Richard
Published: March 2020

Maize (Zea mays L.) production in West and Central Africa is constrained by drought, low soil-N and Striga infestation. Breeders in the region have developed and commercialized extra-early and early-maturing hybrids (E-EH and EH), which combine high yield potentials with tolerance/resistance to the three stresses. Hybrids of both maturity groups are new to the farmers; thus, the urgent need to recommend appropriate agronomic practices for these hybrids. We investigated the responses of four hybrids belonging to extra-early and early-maturity groups to plant density (PD) and nitrogen (N) application in five agroecologies. The EHs consistently out-yielded the E-EHs in all the five agroecologies. The hybrids showed no response to N-fertilizer application above 90 kg ha-1. All interactions involving N had no significant effect on all traits except in few cases. The E-EHs and EHs had similar response to PD; their grain yield decreased as PD increased. Contrarily, flowering was delayed and expression of some other agronomic traits such as plant and ear aspects became poorer with increased PD. Optimal yield was obtained at approximately 90 kg N ha-1 and 66,666 plants ha-1. Most of the measured traits indicated high repeatability estimates (i.e. ≥ 60) across the N levels, PDs and environments. Evidently, the hybrids were intolerant of high PD.
Estimation of Flexible Pavement Structural Capacity Using Machine Learning Techniques
Authors: Karballaeezadeh Nader , Ghasemzadeh Tehrani Hosein , Mohammadzadeh S. Danial , Shamshirband Shahaboddin
Published: March 2020

The most common index for representing structural condition of the pavement is the structural number. The current procedure for determining structural numbers involves utilizing falling weight deflectometer and ground-penetrating radar tests, recording pavement surface deflections, and analyzing recorded deflections by back-calculation manners. This procedure has two drawbacks: 1. falling weight deflectometer and ground-penetrating radar are expensive tests, 2. back-calculation ways has some inherent shortcomings compared to exact methods as they adopt a trial and error approach. In this study, three machine learning methods entitled Gaussian process regression, m5p model tree, and random forest used for the prediction of structural numbers in flexible pavements. Dataset of this paper is related to 759 flexible pavement sections at Semnan and Khuzestan provinces in Iran and includes “structural number” as output and “surface deflections and surface temperature” as inputs. The accuracy of results was examined based on three criteria of R, MAE, and RMSE. Among the methods employed in this paper, random forest is the most accurate as it yields the best values for above criteria (R=0.841, MAE=0.592, and RMSE=0.760). The proposed method does not require to use ground penetrating radar test, which in turn reduce costs and work difficulty. Using machine learning methods instead of back-calculation improves the calculation process quality and accuracy.
A Novel Role for the Tumor Suppressor Gene ITF2 in Lung Tumorigenesis and Chemotherapy Response
Authors: Pernia Olga , Sastre-Perona Ana , Rodriguez-Antolin Carlos , Garcia-Guede Alvaro , Palomares-Bralo Maria , Rosas Rocío , Sanchez-cabrero Dario , Cruz Patricia , Rodriguez Carmen , Diestro MDolores , Martin-Arenas Ruben , Pulido Veronica , Santisteban Pilar , de Castro Javier , Vera Olga , Ibanez de Caceres Inmaculada
Published: March 2020

Despite often leading to platinum resistance, platinum-based chemotherapy continues to be the standard treatment for many epithelial tumors. In this study we analyze and validated the cytogenetic alterations that arise after treatment in four lung and ovarian paired cisplatin-sensitive/resistant cell lines by 1-million array-CGH and qRT-PCR methodologies. RNA-sequencing, functional transfection assays and gene-pathway activity analysis were used to identify genes with a potential role in the development of this malignancy. Results were further explored in 55 lung and ovarian primary tumors and control samples and in two extensive in silico databases. Long-term cell exposure to platinum induces the frequent deletion of ITF2 gene. Its expression re-sensitizes tumor cells to platinum and recovers the levels of Wnt/β-catenin transcriptional activity. ITF2 expression was also frequently downregulated in epithelial tumors, predicting a worse overall survival. We also identified an inverse correlation between ITF2 and HOXD9 expression, revealing that NSCLC patients with lower expression of HOXD9 have a better overall survival rate. We define the implication of ITF2 as a molecular mechanism behind the development of cisplatin resistance probably through the activation of the Wnt-signaling pathway. This data highlights the possible role of ITF2 and HOXD9 as novel therapeutic targets for platinum resistant tumors.