bluuebunny/crossref_metadata_2025 huggingface dataset:
Machine Learning-Based Virtual Screening Strategy RevealsSome Natural Compounds as Potential PAK4 Inhibitors in Triple Negative Breast Cancer
Authors: Iwaloye Opeyemi , Elekofehinti Olusola O. , Kikiowo Babatomiwa , Oluwarotimi Emmanuel A. , Fadipe Toyin M.
Published: December 2020

Background:

P-21 activating kinase 4 (PAK4) is implicated in the poor prognosis of
many cancers, especially in the progression of Triple Negative Breast Cancer (TNBC). The present
study was aimed at designing some potential drug candidates as PAK4 inhibitors for breast cancer
therapy.

Objective:

This study aimed to finding novel inhibitors of PAK4 from natural compounds using
computational approach.

Methods:

An e-pharmacophore model was developed from docked PAK4-co-ligand complex and
used to screen over a thousand natural compounds downloaded from BIOFACQUIM and NPASS
databases to match a minimum of 5 sites for selected (ADDDHRR) hypothesis. The robustness of
the virtual screening method was accessed by well-established methods including EF, ROC, BEDROC,
AUAC, and the RIE. Compounds with fitness score greater than one were filtered by applying
molecular docking (HTVS, SP, XP and Induced fit docking) and ADME prediction. Using Machine
learning-based approach QSAR model was generated using Automated QSAR. The computed
top model kpls_des_17 (R2= 0.8028, RMSE = 0.4884 and Q2 = 0.7661) was used to predict the
pIC50 of the lead compounds. Internal and external validations were accessed to determine the predictive
quality of the model. Finally, the binding free energy calculation was computed.

Results:

The robustness/predictive quality of the models was affirmed. The hits had better binding
affinity than the reference drug and interacted with key amino acids for PAK4 inhibition. Overall,
the present analysis yielded three potential inhibitors that are predicted to bind with PAK4 better
than the reference drug tamoxifen. The three potent novel inhibitors, vitexin, emodin and ziganein
recorded IFD score of -621.97 kcal/mol, -616.31 kcal/mol and -614.95 kcal/mol, respectively while
showing moderation for ADME properties and inhibition constant.

Conclusion:

It is expected that the findings reported in this study may provide insight for designing
effective and less toxic PAK4 inhibitors for triple negative breast cancer.
Thoughts of Death, Depression and Guilt in a Healthcare Worker Who Infected Her Husband with SARS-CoV-2: A Case Report
Authors: Berardelli Isabella , Vaia Antonio , Pompili Maurizio
Published: December 2020

Background:

The worldwide spread of the novel coronavirus (SARS-CoV-2) has exposed
healthcare workers (HCWs) to physical and mental disorders both directly and indirectly related
to the pandemic. Italy was the first European country affected by the SARS-CoV-2 pandemic,
and Italian HCWs have presented adverse psychological outcomes related to work and emotional
overload and the fears of becoming infected and infecting others, particularly loved ones.

Case Presentation:

We report the case of a 61-year-old HCW who likely infected her husband
with SARS-CoV-2, leading to his death. We assessed the depressive and anxious symptoms that
the patient experienced after the death of her husband, which were characterized by a deep sense of
guilt, psychological pain, and thoughts of death.

Conclusion:

In our opinion, our case emphasizes the fact that HCWs need greater mental health assistance,
particularly those who are heavily involved in the care of patients and who have possible
risk factors for psychiatric symptoms.
Hypersensitivity to Vitamins with a Focus on Immediate-Type Reactions: Food or Drug Allergy?
Authors: Calogiuri Gianfranco , Garvey Lene H. , Nettis Eustachio , Casciaro Francesco , Alsowaidi Shirina , Foti Caterina , Vacca Angelo
Published: December 2020

Vitamins are essential substances for normal cell functions, growth, and development.
However, they cannot be produced by the human organism, so intake must be through the diet. Vitamin
deficiency causes the onset of different diseases, ranging from pellagra to pernicious anemia,
which can be corrected by reintroducing the missing vitamin form. To supply the right amount of
vitamins to the body, every vitamin naturally occurring in foodstuff has been identified, extracted
and synthetically produced, thus allowing either food fortification with these compounds or their
pharmaceutical production. Furthermore, the increased importance attributed nowadays to body
wellness and the pursuit of a permanent status of health at all costs has greatly encouraged a high
consumption of vitamin supplements in modern society, since vitamin megadoses may be responsible
for adverse or toxic effects. However, excessive vitamins can induce hypervitaminosis. In the
USA, a national survey confirmed that 52% of adult Americans take at least one or more supplement
products, vitamins and minerals being the most popular supplements in that country. Although
vitamins are widespread natural substances, they may induce immediate or delayed type hypersensitivity
reactions. Such adverse events are still underestimated and poorly recognized because
only single cases have been reported in the literature, and no general review has yet investigated
the mechanisms underlying sensitization to each vitamin, the diagnosis, and the management
strategies adopted for vitamin hypersensitivity. Although delayed-type reactions to different vitamins
are described in the literature, in our review, attention has been focused mainly on immediate-
type reactions. Due to the importance of vitamins, further information regarding the above aspects
(pathomechanisms, diagnosis and management) would be highly desirable to focus the state
of the art on this particular, underestimated form of allergy, thus increasing allergists' awareness on
these elusive hypersensitivity reactions.
Application of Liposomes in Cancer Therapy: An Assessment of the Advancement of Technology Through Patent Documents
Authors: Nunes Danielle D.G. , Leal Ingrid L. , Oliveira Fabricia O. , da Silva Tatiara L.R. , de Senna Valter , Machado Bruna S. S.
Published: December 2020

Background:

Cancer is caused by mutations in oncogenes and loss of tumor suppressor
activity. Despite the efforts of the pharmaceutical industry to fight cancer, it is necessary to investigate
new methods to enhance the action against this disease. In this scenario, liposome technology
has emerged as a drug delivery system for cancer treatment. The objective of this study was to evaluate
the use of liposome technology in the treatment of cancer through analysis of patent documents.

Methods:

We analyzed prospective documents in the Derwent Innovation Index database.

Results:

A total of 203 patent documents were related to the area of interest, published between 2000
and 2020, and the USA and Japan were shown as countries with the largest number of publications.
Moreover, most of these publications came from companies, however, also with the representation of
important universities, mainly the University of California. According to the International Patent
Classification, the codes most applicable to the documents were in the areas of human necessities and
chemistry.

Conclusion:

The results of this study showed that the study and application of liposomes for the
development of cancer treatment tended to grow, along with the number of related patents.
Two-Dimensional Transitional Metal Disulfides as Charge Transport Layers
in Organic-Inorganic Perovskite Solar Cells
Authors: Zheng Huanhuan , Niu Bingqiang , Wang Yijin , Zhong Peng , Ma Xiaohua , Javed Hafiz Muhammad Asif
Published: December 2020

In the past decade, organic-inorganic perovskite solar cells (PSCs) have received great attentions due to their
high efficiencies and low costs. However, the commercialization of PSCs is stilled hindered by several issues such as
device performance (especially for large-area cells) and stability. Recently, two-dimensional (2D) transition metal
disulfides (TMDs) show great potentials in solving aforementioned problems due to their unique morphological structure
and electrical properties. Herein, we summarize the advancements in the recent applications of various TMDs materials as
charge transport layers in PSCs. Although some progresses have been made, there are considerable issues to be tackled in
this field. The challenges and development directions of these 2D TMDs materials for PSCs are also clarified. Lastly, the
most recent advancements about TMDs materials in some other electronic (or optoelectronic) fields are also summarized
and discussed.
Knowledge, Attitude, Practice, Motives and Barriers Towards Scientific Research among Dentists and Dental Students in Saudi Arabia
Authors: Abdulrahman Somaya , Aboalshamat Khalid , Muthana Malak , Sait Ghaida , Bantan Nuran , Hafiz Shuruq , Mahrous Renad , Alsuhaqi Aishah
Published: December 2020

Background:

Research is crucial for the scientific progress of the health of individuals, communities, and systems. The aim of this study was to assess the knowledge, attitude, motives and barriers among dentists and dental students in the western region of Saudi Arabia.

Objective:

This study aims to assess the level of knowledge, attitude, motives and barriers toward scientific research among dentists and dental students in the western region of Saudi Arabia.

Methods:

We conducted a cross-sectional study of 467 dentists and dental students using a convenience sampling method from seven dental colleges, major governmental and private dental clinics in the Western region of Saudi Arabia. We used a validated self-report questionnaire to collect data and assess the knowledge of, attitude towards and barriers to scientific research.

Results:

The participants (who are dentists and dental students) have a total knowledge score of m=4.57, SD=2.46, which is slightly lower than the midpoint. Participants who work in governmental clinic were significantly (F (2,464) =13.71, p<0.001) more knowledgeable than those who worked in private clinic and the students. Most participants had positive general and personal attitudes toward scientific research. Of the participants, 40.5% to 60.4% were involved in research activities, and 37.3% have submitted or published scientific articles. The most common motive for scientific research was receiving credit for post-graduate application (58.46%). The most common organizational barrier to conduct a research was the difficulty of finding research supervisor (39.19%) and lack of time due to work overload (32.55%). While most common personal barriers were lack of knowledge/skills (38.76%), lack of personal time (36.83%) and receiving credit for postgraduate application.

Conclusion:

Saudi dentists and dental students had a moderate level of knowledge and practice in research, but their attitude was highly positive. More efforts are needed to facilitate scientific dental research including supervisors’ availability and time allocation for research. The study has some limitations including using convenience sample from one region and self-report questionnaire that decreases the external validity of the study and increases the potential for self-reported biases.
Evaluating the Failure of Resin-based Materials on the Proximal Cervical Dentin
Authors: Kochotwuttinont Sukamon , Wayakanon Kornchanok
Published: December 2020

Background:

Resin-based materials are the popular restorative material in dentistry. The majority of these materials are light cured with a major disadvantage: marginal leakage.

Objective:

To evaluate the gap width of different resin-based materials at the cervical dentin when achieved mechanical force.

Methods:

Class II cavities were prepared on extracted premolar teeth with the gingival margin 1 mm below the Cementoenamel Junction (CEJ). In the first three experimental groups, three different lining materials (flowable resin composite, bulk-fill flowable resin composite, and resin-modified glass ionomer cement) were placed at the cervical dentin with a thickness of 1 mm. The rest of the cavities were restored with conventional resin composite. The other two groups were restored with conventional resin composite (control) or high viscosity bulk-fill resin composite, respectively. All groups were thermocycled and underwent vacuum pressure 2.6 KPa for 30 min in a Scanning Electron Microscope (SEM).

Results:

There was no gap formation at the cervical dentin on the external surface when restored with high-viscosity bulk fill resin composite. Almost all gaps occurred at the interface between restorative materials and the hybrid layer. The flowable bulk fill resin composite showed a significantly smaller gap width on both the external and internal surfaces compared to the other groups (p< 0.05). The resin-modified glass ionomer cement showed the largest gaps in the cervical dentin (p < 0.05).

Conclusion:

The different types of resin-based materials demonstrated a different failure of gap width under mechanical force. It clearly occurred at the restorative material-hybrid layer interface.
Identification of Protease Inhibition Mechanism by Iturin A against Agriculture Cutworm (Spodoptera litura) by Homology Modeling and Molecular Dynamics
Authors: Papathoti Narendra Kumar , Kiddeejing Dusadee , Daddam Jayasimha Rayulu , Le Thanh Toan , Buensanteai Natthiya
Published: December 2020

Objective:

Spodoptera litura, otherwise known as cutworm, belongs to the Noctuidae tribe, which is a severe scourge for numerous crop systems and is considered one of Asian tropical agriculture's most important insects. The world's leading environmental threats are plant pests, and the already commercialized pesticides are extremely poisonous and non-biodegradable and maybe additional residues harmful to the ecosystem. The increased resistance in pests often demands the need for advanced, active pesticides that are environmentally friendly and biodegradable.

Methods:

In the current work, the significance of proteases for the Spodoptera litura digestive system has been determined by the use of microbial metabolite protease inhibitor (Iturin A) in silico models. In the present study, we developed a model based on sequence structural alignment of known crystal structure 2D1I protease from Homo sapiens. The model's reliability evaluation was performed using programs such as PROCHECK, WHAT IF, PROSA, Validate 3D, ERRAT, etc.

Results:

In an attempt to find new inhibitors for Protease docking, the study was carried out with Iturin A. PMDB ID for the produced protease model was submitted to identify new inhibitors for Protease docking, and its accession number is PM0082285. The detailed study of enzyme-inhibitor interactions identified similar core residues; GLU215, LEU216, LYS217, and GLU237 have demonstrated their role in the binding efficacy of ligands.

Conclusion:

The latest homology modeling and docking experiments on the protease model will provide useful insight knowledge for the logical approach of constructing a wide spectrum of novel insecticide against Spodoptera.
Impact of Ketogenic Diet on Body Composition during Resistance Training among Untrained Individuals
Authors: Hadizadeh Maryam , Gan Wee Yet , Mohafez Hamidreza , Sugajima Yasuhiro
Published: December 2020

Background:

Resistance training (RT) has been established as the most efficient approach for lean body mass maintenance required for preserving a sufficiently high metabolism during weight loss.

Objective:

This study aimed to evaluate the impacts of the ketogenic diet (KD) and regular diet (RE) in combination with 8-week resistance exercise (RT), on body weight, body fat mass (BFM), and lean body mass (LBM) of untrained individuals.

Methods:

Twenty untrained participants were randomly assigned to the RE+RT and KD+RT as control and experimental groups, respectively. Sixty to ninety minutes of diversified resistance exercise were performed by both groups, three sessions weekly, and diet was self-administered with a recommended daily energy and protein intakes. Body composition was measured using a Bioelectrical Impedance Analyzer. One-way Analysis of Covariance (ANCOVA) was applied to analyze the data.

Results:

The results showed a greater post-intervention adjusted mean for body weight and LBM in the normal dietary group in comparison with the experimental group. After controlling for baseline measurements, there was a statistically significant difference in body weight (p < .0005) and BFM (p =.001) between groups.

Conclusion:

Resistance training along with a ketogenic diet may decrease BFM without notable changes in LBM, whilst RT on a normal diet might increase LBM without remarkably influencing BFM.
IMPROVING STUDENTS’ READING COMPREHENSION USING VIP (VOCABULARY INVESTOR PACKAGE) MEDIA AT SMKN 1 BATU
Authors:   SMKN 1 Batu, Dwi Wahyuni Indah , Crista Wijayanti Erythrina ,   Universitas Negeri Malang
Published: December 2020

One of main concerns of the most English as Foreign Language (EFL) teachers is how to assist the students to develop English language proficiency. In this regard, reading is considered as a crucial part of the EFL learning process. The major goal of teaching reading is students are able to recognize the words and convey the meaning of them. Vocabulary seems to gain far more attention as the students had difficulties of interpreting the words that interferes their reading comprehension. Given such limitation of the students’ competence, their motivation may become low. Having seen this phenomenon, the teacher should maximize opportunities for students to improve their reading comprehension as well as their motivation. To this end, this research investigates the implementation of VIP (Vocabulary Investor Package) Media to enhance students’ reading comprehension. The research conducted Classroom Action Research (CAR) by employing 2 cycles to 28 students of twelve grade at SMKN 1 Batu. Accordingly, the procedures included planning, implementing, observing, and reflecting. The results show that (1) the highest score in cycle 2 was higher than the highest score in cycle 1; (2) the lowest score in cycle1 increased compared to cycle 1; (3) the average score was better than in cycle 1; (4) the percentage of students who achieved the minimum criterion (KKM) in cycle 2 was improved rather than in cycle 1; and (5) the percentage of students who did not reached KKM was decreased compared to cycle 1. Therefore, the use of VIP (Vocabulary Investor Package) Media successfully improves students’ reading comprehension. For the effective implementation, this suggests that applying VIP media to the other skills is highly required.
IMPROVING MOTIVATION OF LEARNING ENGLISH SUBJECT THROUGH INTEGRATION OF URBAN LEGEND LITERACY - A SHORT PLAY IN NARRATIVE TEXT OF TETH GRADE STUDENTS AT SMAN 8 MALANG
Authors:   SMAN 8 Malang, Maria K Evy , Nur Adhitama Prambudi ,   Universitas Negeri Malang
Published: December 2020

This study aims at implementing integration teaching technique between Urban legend literacy with short-play in narrative text for educational purposes It uses as teaching strategies on improving students motivation and to raise further comprehension on important value of narrative text. The researh design was Classroom Action Research (CAR) design with qualitative approach. Interview guide, questionnaire, and rating scale were used as research instruments. The steps were planning, implementing observing, and reflecting. The participants of this study were tenth grade (X) students from the class of MIPA 6 and IPS 1 & 2 in SMAN 8 Malang. The data was analyzed qualitatively. Regarding the result of this present study, it is showed that this integration teaching technique was significantly effective and appropriate to be applied for tenth grade students, This technique also encourages students in discovering diverse range of National Urban Legend Literacy to be preserved. This study gave contributions in supporting English language learning in Indonesia, increasing the students’ motivation in learning English, and making the process of teaching and learning English becoming more interesting.
Vocational High School’s Students Motivation and Anxiety in Learning English at EFL Context
Authors: Maylani Alfila
Published: December 2020

English is difficult to study by foreign language students especially Vocational High School’s students because English has its own language structure which is different with Bahasa Indonesia’s language structure which is more complicated. As a result, students are not interested in learning English and they have anxieties in learning English. For example, feeling afraid of negative feedbacks of their participation in English class, feeling anxiety towards the, communication during English class, feeling terrified towards assessment in English class [1]. However, not at all students only have anxieties, some students also have motivation to learn English. There are two kinds of motivation, which are intrinsic and extrinsic. In this research, the writer uses descriptive qualitative method. The subject of this study was the first-grade students of SMK Negeri 4 Malang which consist of 35 students from X DG E class. The writer used two instruments which were questionnaire and interview for 4 selected students. The result of the questionnaire showed that the students intrinsic and extrinsic motivation was “high” with variable mean was 2.910. It was supported the result of interview; they intrinsically feel happy to learn English and they extrinsically learn English to pass the exam. Meanwhile, the finding of this research showed that the students’ anxiety was “low” with the variable mean was 2.427. It was supported the result of interview, that they do not feel anxious towards English class. Therefore, it suggests the students to maintain their motivation and eliminate anxiety in order to improve the students’ achievement in learning English.
Health-related Quality of Life of Cancer Caregivers in Klang Valley, Malaysia
Authors: Abdullah Nik Nairan , Idris Idayu Badilla , Yamat Hamidah , Abdullah Nik Muhd Aslan
Published: December 2020

Cancer caregiving has an impact on the quality of life (QOL) of the caregivers. This cross-sectional study determined the health-related QOL (HRQOL) of gastrointestinal cancer caregivers and associated factors across gender. A total of 323 respondents from major hospitals in Klang Valley completed HRQOL questionnaire from October 2017 to April 2018. Males had a better quality of life compared to females, mean HRQOL score 85.52 (SD=21.16) vs 77.66 (SD=21.36). The significant factors were: relationship between the caregiver and the patient; education level; employment status, marital status, household income and presence of disease. The gender role is vital for targeted intervention.
Keywords: health-related quality of life; gastrointestinal cancer; caregivers; gender
eISSN: 2398-4287© 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v5i15.2453.
Knowledge and Practice on Breast Cancer among Female Community in Puncak Alam Campuses
Authors: Nordin Roswati , Hassri Myzanuddin Hakim , Rozeman Nur Farrah Nasuha , Zulkifli Farah Wahidah
Published: December 2020

In Malaysia, breast cancer is the primary cause of cancer-related death among women. It affected younger women correlates with poor survival and early detection can increase the quality of life. The study aims are to evaluate breast cancer awareness among the female community in UiTM Puncak Alam Campuses. A cross-sectional approach was used while conducting the study. It is found that the level of knowledge of breast cancer awareness relatively fair, and the level of practice is low. Hence, the proactive approach to instill the awareness on breast cancer must be strengthened by the expert in the field.
Keywords: Breast Cancer; Knowledge; Practice.
eISSN: 2398-4287© 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v5i15.2473.
A Comparative Study of Landmark on Heritage Tourism in Sumatra
Authors: Ginting Nurlisa , Rahman Nurinayat Vinky , Delianur Nasution Achmad
Published: December 2020

Landmark, as part of heritage tourism distinctiveness, has a critical role in enhancing the city identity to make it more attractive and more identified. Sumatera Island has heritage tourism with similar culture and history that can found in Medan, Bukittinggi, and Siak. This research was conducted to determine the comparison of the landmark on the similar heritage tourism in Sumatera. The third essential element of the landmark, i.e., iconic, contrast, and accessibility, was investigated using the mixed-method. This study shows that the monumental buildings and historical story formed as the landmark in those three historic tourist cities.
Keywords: Heritage tourism; place identity; distinctiveness; landmark
eISSN: 2398-4287© 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v5i15.2491.
YEŞİL SATIN ALMA VE YEŞİL TEDARİKÇİ SEÇİMİ: BEYAZ EŞYA SEKTÖRÜNDE BİR UYGULAMA
Authors: SOYER Ayberk , TÜRKAY Beste
Published: December 2020

Teknolojinin artan bir hızla gelişmesi, günümüzde işletmelerin daha fazla çeşit ve miktarda ürünü, daha kısa sürelerde pazara sunabilmelerine imkân sağlamaktadır. Bu durum rekabet avantajı elde etmek isteyen işletmeler için bir fırsat yaratmakla beraber, arz miktarlarındaki yüksek artış oranlarına karşılık taleplerin aynı oranda artmaması ve tüketicilerin daha bilinçli ve duyarlı hale gelmeleri, bu işletmeleri yoğun bir rekabet ortamı içerisine sokmaktadır. Doğal kaynakların hızla tükenmesi, iklim değişikliği, çevre kirliliğinin artması, vb. durumların yarattığı olumsuz etkiler sebebiyle toplumdaki farkındalığın artması ve tüketicilerin daha çevreci ürünleri tercih etmeleri, medyanın ve sivil toplum kuruluşlarının çevresel konulara gösterdiği hassasiyet, genel ve yerel otoriteler tarafından yapılan düzenlemeler, vb. koşullar, işletmeleri ürün yaşam döngüsü boyunca tüm aşamalarda çevreye duyarlı olmaya zorlamaktadır. Bu duyarlılık, üretimde kullanılan her türlü kaynağın azaltılmasını, üretim süreçlerinin çevreyle dost olacak şekilde yapılandırılmasını, kullanılan ambalaj malzemelerinin ve taşıma yöntemlerinin çevreyle dost olması ve yeniden kullanım konusunda gerekli adımların atılmasını gerekmektedir. Bu noktada ürün yaşam döngüsünün ilk aşaması olan satın alma konusunda önemli iyileştirme potansiyeli bulunmakta ve üretimde kullanılacak her türlü girdinin temini için en uygun tedarikçinin seçimi en önemli aşamalardan biri haline gelmektedir. Bu değerlendirmeler ışığında yapılan bu çalışma ile amaçlanan, satın alma süreçlerinde geleneksel tedarikçi seçimi yerine, yeşil tedarikçi seçim süreçlerinin araştırılması ve yeşil tedarikçi seçiminde kullanabilecek kriterlerin belirlenmesidir. Yapılan araştırmalardan hareketle yeşil tedarikçi seçimi için yeni bir karar verme modeli geliştirilmiş ve Türkiye ve Avrupa pazarında önemli bir paya sahip beyaz eşya üreticilerinden biri için tedarikçi seçimi süreci bir vaka analizi ile somutlaştırılmıştır.
DOĞAL YAPI TAŞLARININ FİZİKO MEKANİK ÖZELLİKLERİYLE BÖHME AŞINMA DİRENCİNİN TAHMİNİ
Authors: BOZDAĞ Ali
Published: December 2020

Dünya nüfusunun artmasına bağlı olarak yapı sektöründe doğal yapı taşlarına olan talep her geçen gün artmakta olup doğal taşların kullanım alanlarının doğru tespit edilebilmesi için fiziko-mekanik özelliklerin belirlenmesi gerekmektedir. Ayrıca fiziko-mekanik özelliklerinin belirlenmesi doğal taşların kullanım alanlarındaki davranışlarının da anlaşılması açısından önem arz etmektedir. Doğal taşların kullanım alanlarına göre belirlenmesi gereken mekanik özelliklerden birini oluşturan aşınma direncinin tespiti için yaygın olarak kullanılan yöntem Böhme aşınma testidir. Bu çalışma da farklı kökenli kayaçların (magmatik, metamorfik, sedimanter) fiziko-mekanik özelliklerinin belirlenmesiyle aşınmaya karşı dayanım dirençlerinin tahmini istatistiksel yöntemlerle incelendi. Bu amaçla Anadolu’nun farklı bölgelerinden farklı kökenli doğal taş örnekleri toplanmış ve bu örneklerde Böhme aşınma deneyi ve fiziko-mekanik deneyler yapılmıştır. Doğal taşların Böhme aşınma direnci ile kuru yoğunluk, porozite, ağırlıkça su emme, P dalga hızı, Schmidt çekiç değeri, tek eksenli basma değerleri arasındaki ilişkiler basit regresyon ve çoklu regresyon analizleriyle incelenmiştir. Çoklu regresyon analiziyle geliştirilen denklem yardımıyla belirlenen Böhme aşınma direnç değerleri ile deneysel yöntemlerle belirlenen Böhme aşınma direnç değerleri arasında R2=0,92 olarak belirlenmiştir. Yapılan bu çalışma ile farklı doğal taşların aşınma direncinin tahmininde Böhme aşınma testinden farklı olarak diğer fiziko-mekanik özelliklerden elde edilebilecek denklemler geliştirilmiştir.
EŞ EKSENLİ ELEKTRO LİF ÇEKİM YÖNTEMİ İLE TERMAL ENERJİ DEPOLAMA ÖZELLİKLİ KOMPOZİT NANOLİF ÜRETİMİ ÜZERİNE BİR ARAŞTIRMA
Authors: ÖZMEN Gizem , ALAY AKSOY Sennur
Published: December 2020

Bu çalışmada, katı-sıvı faz değişim maddesi (FDM) olan yağ asitleri eş eksen düzeli (iç içe geçmiş iki düze) elektro lif çekim sistemi kullanılarak polimer kılıf tarafından kapsüllenmiştir. Böylece FDM’nin nanolif yapı içerisine öz madde olarak hapsedilmesi ve öz/kılıf yapısında ısı depolama/yayma özellikli kompozit nanoliflerin üretimi gerçekleştirilmiştir. Çalışmada nanolif üretimi için polimetil metakrilat (PMMA) polimeri, FDM olarak kaprik asit (KA), laurik asit (LA) ve miristik asit (MA) yağ asitleri kullanılmıştır. Üretilen nanoliflerin 19 ile 144 j/g aralığında değişen oranlarda ısı depolama özellikleri ve minimum 195 °C ve üzeri termal bozunma sıcaklıkları sundukları belirlenmiştir. Yağ asidi çözeltisinden ibaret öz madde içerisine iletken grafen ilavesinin homojen çaplı, düzgün yüzeyli ve silindirik şekle sahip nanolif üretimine olanak sunduğu belirlenmiştir. En yüksek enerji depolama kapasitesi laurik asit için elde edilmiş ve özellikle laurik asit/PMMA ve kaprik asit/PMMA içerikli kompozit nanoliflerin yüksek ısı depolama kapasitesine sahip termal enerji depolama malzemesi olarak kullanılabileceği sonucuna varılmıştır.
Уважаемые коллеги!
Authors: Tsymbaliuk V. І.
Published: December 2020

No abstract
Уважаемые коллеги!
Authors: Schnayder S. А.
Published: December 2020

No abstract
The Heavy Metals in the Soils of the Republic of Kalmykia based on the 2019 Data
Authors:   Kalmyk Scientific Center of the RAS, Buluktaev Aleksey , Adyanova Altana ,   Kalmyk Scientific Center of the RAS
Published: December 2020

Цель. В данной статье исследуется содержание тяжелых металлов в почвах на территории 13 районов Республики Калмыкия и города Элисты за 2019 г. Методы. Для изучения содержания тяжелых металлов в почвах образцы почв были отобраны с территории дошкольных образовательных учреждений, селитебной территории, зон рекреаций и лечебно-профилактических учреждений. Определение тяжелых металлов проводили методом атомно-абсорбционной спектрофотометрии с пламенной атомизацией на абсорбционном спектрофотометре. Результаты. В результате исследования нами были получены следующие данные: содержание ртути и кадмия во всех исследованных почвах не превышает 0,100 мг/кг, высокие концентрации свинца, превышающие 7,000 мг/ кг, зафиксированы в почвах Городовиковского, Юстинского и Яшалтинского районов Республики Калмыкия. Относительно высокие концентрации цинка зафиксированы в почвах Городовиковского, Яшалтинского и Юстинского районов (25,466–33,833 мг/кг), содержание меди в почвах Калмыкии варьирует в широких пределах от 0,000 мг/ кг до 6,733 мг/кг. Выводы.Доказано,что содержание исследуемых тяжелых металлов в почвах на территории дошкольных образовательных учреждений, лечебно-профилактических учреждений всех районных центров Республики Калмыкия и города Элисты не превышает предельно допустимых концентраций.
The Analysis of the Forest Suitability of the Light-Chestnut Soils for Forest Reclamation
Authors:   Federal Research Center of Agroecology, Integrated Land Reclamation and Protective Afforestation of the RAS, Sytin Gennadiy
Published: December 2020

Цель настоящего исследования — изучение современного состояния почвенных условий для выявления их пригодности для создания защитных лесонасаждений. Материал и методы. Исследования проводились на модельных участках сельскохозяйственных предприятий, расположенных в Волго-Донском междуречье в сухостепной провинции с зональными светло-каштановыми почвами. Изучение современного состояния проводилось по общепринятым методикам описания почвенных профилей и агрохимического анализа образцов. Результаты. Исследования показали, что почвенный покров на модельных участках достаточно сложный, что обусловлено разнообразными рельефом и почво-образующими породами. Полевыми изысканиями выявлено 29 разновидностей светло-каштановых почв различного гранулометрического состава и степени засоления. Выводы. На модельном объекте детальное обследование позволило выделить наиболее плодородные почвенные разности и распределить лесомелиоративный фонд на категории с разными почвенными условиями. Для создания устойчивых и долговечных насаждений рекомендуется отводить светло-каштановые среднесуглинистые почвы. Разнокачественность лесорастительных условий вызывает необходимость детально исследовать почвенные условия при планировании мероприятий по лесоразведению.
The Analysis of the Pasture Vegetation Species Composition on the Territory of the Khanata Municipal Unit of the Maloderbetovskiy Region of the Republic of Kalmykia
Authors:   Institute for Comprehensive Studies of Arid Territories, Bembeeva Olga
Published: December 2020

Цель исследования заключается в мониторинге современного состояния пастбищной растительности на территории Ханатинского СМО Малодербетовского района Республики Калмыкия. Материалы и методы. Материалом для публикации послужили наблюдения и учеты, выполненные в 2012–2019 гг. на пастбищных полигонах Ханатинского сельского муниципального образования с применением наземных и дистанционных методов изучения ландшафтов. При проведении исследования использовались классические методы. Результаты. В статье приведены результаты таксономического, биоморфологического, эколого-ценотического анализов растительных сообществ территории Ханатинского СМО Малодербетовского района Республики Калмыкия. Общее видовое богатство изученных фитоценозов составило 151 вид сосудистых растений, относящихся к 103 родам и 24 семействам. Наиболее многочисленными семействами являются Asteraceae, Chenopodiaceae, Poaceae и Brassicaceae. Лидирующими родами являются Artemisia (6 видов), Limonium (5 видов), Petrosimonia (4 вида). Выводы. Доминирующую роль во флоре исследуемых ключевых участков занимают поликарпические (49,0 %) и монокарпические травы (43,7 %). Доля полукустарничков составляет 6,0 %, полукустарников — 1,3 %. По приуроченности к определенным типам местообитаний большинство видов относится к степному типу растительности (74,8 %). Пустынные виды представлены наименьшим количеством (8,6 %). По отношению к влаге большинство видов растений относится к ксерофитам (45,7 %), по отношению к засолению около 20 % всех растений относится к галофитам, что характерно для данной территории. Выявлено 10 видов редких и исчезающих растений, занесенных в Красные книги РФ и Республики Калмыкия.
State youth policy and its role in social development
Authors:   Far-East Institute of Management – branch of the RANEPA, BEREZUTSKIY YURI V. , BAYKOV NIKOLAY M. ,   Far-East Institute of Management – branch of the RANEPA
Published: December 2020

The article presents the analysis of the state youth policy as an instrument of influence on the state and social development of youth, its social activity. The contradictions that exist between the performance indicators declared by the state policy and the real problems of youth, determined by the living conditions, are indicated. Based on the results of all-Russian and regional sociological studies and statistics, the motives of migratory movements of youth from their territories of residence to the centers of gravity of the country and foreign countries that have more attractive living and employment conditions for youth are justified. Using the example of the Russian Far East, the dysfunctional consequences of the clerical-bureaucratic approach laid down in the state youth policy to quantify the state of youth ignoring its large-scale migration outflow from the territories of residence are substantiated. Scientific and practical recommendations on improvement of indicators of the state youth policy promoting strengthening of its role in providing the basic needs of youth in various spheres of activity, especially in development of youth business are offered.
Advantages, problems, and prospects of legal regulation of the digital economy in the Russian Federation
Authors:   State committee on investments and state property management of the Republic of Tajikistan, AHMADZODA NOWROZ SOBIT
Published: December 2020

The article analyzes the problems and formulates proposals aimed at improving regulation and developing the digital economy. The problem of information security and privacy protection is especially acute when considering Big Data, which are the most important object links. Russian legislation specifies certain legal aspects for special processing of information with particular value. The national program “Digital Economy of the Russian Federation” analyzed in the article covers all spheres of economic and social life, has a detailed roadmap, the implementation of which is provided until 2024, and involves scientifically based selection of resources, training professionals, developing talented youth, as well as increasing interest and improving the computer literacy of the population on the Internet. The article outlines public and private prospects for the implementation of the digital economy in all areas of production, economic activity, and the service sector. It was determined that it is necessary to standardize data processing, create adequate data storage facilities, ensure their uninterrupted operation, create conditions under which digital data cannot be lost, and also create tools for assessing the services provided. It was revealed that there is a shortage of both highly professional personnel and personnel providing education and training of specialists. Existing educational programs and standards need to be improved. The problems of introducing the digital economy are outlined. The author proposes a number of changes to the current legislation in order to improve the regulation of the development of the digital economy.
Assessment of contribution by corporate structures of the construction business to the economic development of territories
Authors:   Russian Presidential Academy of National Economy and Public Administration, RAEVSKY SERGEY V. , BELYAEVSKAYA-PLOTNIK LYUBOV A. ,   Institute of Economics and Crisis Management, ROMASHIN ANDREY A. ,   “Menshen” Real Estate Agency
Published: December 2020

The article considers the development of methodology for assessing the contribution of corporate structures of the construction business to the economic development of territories. In the article, a specific theoretical approach is used, i. e. when choosing the instruments of regional administration, it is required to use precisely those, which with a minimum impact will lead to maximum effectiveness. When working on this hypothesis, appropriate estimates are used to assess the contribution of large corporate structures of the construction business to the creation of the Gross Regional Product with the usage of correlation- regression models. The adoption of effective management decisions to a large extent depends on the selection of the right areas of impact on those types of businesses that form the largest share of value-added. This approach allows us to highlight the tools to support the corporate structures of the construction business in developing the economic policy of the region.
5G: features, fields of application, threats to national security
Authors:   JSC «Militzer and Münch», ALFEROV SERGEY Y.
Published: December 2020

The article provides the review of the specifications of the 5G, which determine the possibility of its use in qualitatively other areas compared to previous generations of mobile communication systems. Besides, areas of application of 5G, as well as examples of the potential implementation of it in them were singled out. It is shown that such a link can be used for both private and public needs, and when implemented in the defense sector – and for the state. 5G has a number of competitive advantages. Its implementation opens up new opportunities for the full development of the Internet of things, smart cities, unmanned vehicles and a number of other areas. However, along with opportunities there are certain threats, including the national security of the state. In particular, the 5G network may be attacked in order to disrupt its functioning. This can potentially lead to paralysis of part of the economy. The subject of such an attack can be both state and non-state actors. The author identified threats to national security that may arise as a result of the use of 5G. It was proposed to divide them into two categories: direct and indirect. The first one is connected with the communication itself, its software and hardware, the second - with certain areas of its application and socio-economic sphere. The untimely introduction of fifth-generation communications could exacerbate the country’s technological backwardness. The use of 5G exclusively in large cities will create a risk for the spatial development of the state.
Prospects for the development of international cooperation in the Arctic: main directions
Authors:   Federal Assembly of the Russian Federation, SMORCHKOVA VERA I.
Published: December 2020

Over the past three decades, the Arctic has shown an unprecedented pace of international cooperation. Work in this direction takes place within the framework of the Arctic Council, the Barents Euro-Arctic Region Council (BEAC), the Northern Forum, the International Arctic Science Committee, the International Conference “Arctic Frontiers”, the Conference of Parliamentarians of the Arctic Countries, the University of the Arctic, etc. Cooperation and integration of the Arctic regions are of great importance for the social and economic development of this macro-region. United, the Arctic countries will preserve and develop territories on the principles of sustainable development. While studying the topic of the article, the author realized that the existing initiatives are not enough to meet the growing needs of the region. Today, the circumpolar region faces geopolitical, socio- economic, and environmental challenges. Changes in economic development and global warming are a serious threat to the population of the Arctic. Governmental and non-governmental organizations associated with activities in the Arctic, as well as its direct residents, are interested in international cooperation in various areas that are related to the problems of the region. The participation of countries and organizations is needed for an immediate response to changes, as well as to solve emerging problems, to pursue common interests, and to find effective mechanisms for managing emerging changes. In the article, the author also offers practical recommendations for the proper use of the potential of the Russian Arctic.
Depression Level Of Adolescent In Banyuwangi Based On Gender Using Beck Depression Inventory-II
Authors: Purwoningrum Ary's Kusumaayu
Published: December 2020

Depression can interfere with the mood that affects a person's feelings, thinking ability, and completing daily activities. Symptoms of depression include prolonged sadness and loss of interest in doing activities that are usually done, followed by a decrease in the ability to carry out activities. Based on data from WHO in 2015, the proportion of the global population experiencing depression is estimated at 4.4%. Meanwhile, based on a survey from Riskesdas in 2018 showed that depression began to occur in the 15-24 year age group with a prevalence of 6.2%. Adolescents are an age group that is vulnerable to depression. This study aims to determine the level of depression in students of OSIS management of vocational high schools (SMK) in Banyuwangi based on gender using BDI-II (Beck Depression Inventory-II). This research is a descriptive type of research with a quantitative approach using a total population of 51 people of the student organization management of vocational high schools (SMK) in Banyuwangi. The questionnaire used is BDI-II (Beck Depression Inventory-II) which consists of 21 statements. The respondents' answers were categorized into 4 levels of depression categories, namely no depression, mild depression, moderate depression and major depression. Male students who did not depression were 41.7%, mild depression were 16.6%, moderate depression were 41.7%, and major depression were 0%. The female students who did not depression were 56.4%,  mild depression were 35.9%, moderate depression were 7.7%, and major depression were 0%. Depression is more common in women than men
Insights into algae evolution for adapting to blue-green light garnered from the Isochrysis galbana genome
Authors: Chen Duo , Yuan Xue , Zheng Xuehai , Fang Jingping , Lin Gang , Chen Jiannan , Li Daliang , Li Li , He Wejin , Huang Luqiang , Huang Zhen , Li Rongmao , Fu Yajuan , Fan Wenfang , Liang Limin , Chen Nan , Lin Chentao , Zhu Jinmao , Chen Youqiang , Xue Ting
Published: December 2020

Isochrysis galbana is an important producer in the aquatic ecosystem
because of its rich fucoxanthin content and fast growth. However, little
is known about its evolutionary adaptation to live in a specific,
complex and harsh environment. We report a high-quality genome sequence
of I. galbana LG007, which has a 92.73 Mb genome size, a contig N50 of
6.99 Mb and 14,900 protein-coding genes. Phylogenomic inferences
confirmed the monophyly of Haptophyta, showing I. galbana is a sister to
E. huxleyi and C. tobinii. Evolutionary analysis revealed an estimated
divergence of I. galbana from its close relative E. huxleyi
~133 million years ago, and I. galbana underwent one
round of whole-genome duplication. Genes related to environmental
adaptation and metabolic regulation in I. galbana were relatively
conserved, but the basic transcriptional regulation toolkit for
terrestrial plant development has been contracted or was not detected.
The domain identification of one novel fucoxanthin biosynthesis gene
that encodes diadinoxanthin-fucoxanthin hydroxylase (DFH) was
investigated. Comparative genomic analysis revealed that I. galbana
acquired several transcription factors specific to the control of
pigment accumulation and production of LHCX2 to harvest blue-green
light, which facilitates adaptation to the underwater environment. These
findings provide new insights into the genomic characteristics of I.
galbana and algae evolution for adaptation to blue-green
light underwater.