bluuebunny/crossref_metadata_2025 huggingface dataset:
Technical Comment on “Policy impacts of statistical uncertainty and privacy”
Authors: Cui Yifan , Gong Ruobin , Hannig Jan , Hoffman Kentaro
Published: June 2023

Steed
et al
. (

1

) illustrates the crucial impact that the quality of official statistical data products may exert on the accuracy, stability, and equity of policy decisions on which they are based. The authors remind us that data, however responsibly curated, can be fallible. With this comment, we underscore the importance of conducting principled quality assessment of official statistical data products. We observe that the quality assessment procedure employed by Steed
et al
. needs improvement, due to (i) the inadmissibility of the estimator used, and (ii) the inconsistent probability model it induces on the joint space of the estimator and the observed data. We discuss the design of alternative statistical methods to conduct principled quality assessments for official statistical data products, showcasing two simulation-based methods for admissible minimax shrinkage estimation via multilevel empirical Bayesian modeling. For policymakers and stakeholders to accurately gauge the context-specific usability of data, the assessment should take into account both uncertainty sources inherent to the data and the downstream use cases, such as policy decisions based on those data products.
Improving glass nanostructure fabrication
Authors: Colombo Paolo , Franchin Giorgia
Published: June 2023

A new method offers high-resolution three-dimensional printing and low-temperature firing
A super Sonic circadian synchronizer
Authors: Kim Dong Won , Blackshaw Seth
Published: June 2023

Sonic Hedgehog signaling and primary cilia control the core mammalian circadian clock
It matters who does science
Authors: Thorp H. Holden
Published: June 2023

Scientific research is a social process that occurs over time with many minds contributing. But the public has been taught that scientific insight occurs when old white guys with facial hair get hit on the head with an apple or go running out of bathtubs shouting “Eureka!” That’s not how it works, and it never has been. Rather, scientists work in teams, and those teams share findings with other scientists who often disagree, and then make more refinements. Then those findings are placed in the scientific record for even more scientists to examine and produce further adjustments. Eventually, theories become knowledge. All along the way, these scientists are conspicuously and magnificently human—with all the assets and flaws that humans possess. And that means that who those individuals are, and the backgrounds they bring to their work, have a profound influence on the quality of the end result.
Neutropenic Rat Thigh Infection Model for Evaluation of the Pharmacokinetics/Pharmacodynamics of Anti-Infectives
Authors: Yedle Randhir , Reniguntla Mahesh Kumar , Puttaswamy Ramesh , Puttarangappa Pradeep , Hiremath Somashekharayya , Nanjundappa Mahesh , Jayaraman Ramesh
Published: June 2023

Many antibiotics are administered as intravenous infusions in the clinic, especially in intensive care units. Anti-infective drug discovery companies develop clinical candidates that are intended to be administered as i.v. infusions in the clinic.
Overexpression of Eimeria tenella Rhoptry Kinase 2 Induces Early Production of Schizonts
Authors: Ribeiro E. Silva Adeline , Diallo Mamadou Amadou , Sausset Alix , Robert Thomas , Bach Stéphane , Bussière Françoise I. , Laurent Fabrice , Lacroix-Lamandé Sonia , Silvestre Anne
Published: June 2023

Rhoptries are specialized secretory organelles found in zoite stages of apicomplexan parasites. In addition to well-conserved rhoptry neck proteins, their protein consists mostly of kinase proteins, highly divergent from eukaryotic kinases.
Synergistic Antibacterial Effect of Phage pB3074 in Combination with Antibiotics Targeting Cell Wall against Multidrug-Resistant Acinetobacter baumannii
In Vitro
and
Ex Vivo
Authors: Luo Jun , Xie Libo , Yang Min , Liu Min , Li Qianyuan , Wang Peng , Fan Jinhong , Jin Jing , Luo Chunhua
Published: June 2023

Combined application of phages and antibiotics cannot only effectively inhibit the appearance of phage-resistant bacteria, but also reduce the effective use concentration of antibiotics, and even make some bacteria regain sensitivity to some resistant antibiotics. Therefore, phage-antibiotic combination (PAC) could improve the antibacterial activity of individual drug, providing a new choice for clinical treatment of multidrug-resistant bacterial infections.
Vibrio parahaemolyticus from Migratory Birds in China Carries an Extra Copy of tRNA-Gly and Plasmid-Mediated Quinolone Resistance Gene
qnrD
Authors: Zheng Lin , Yang Chao , Chen Ping , Zhu Lingwei , Wen Huiqi , Liu Mingwei , Guan Jiayao , Lu Gejin , Jing Jie , Sun Shiwen , Wang Ying , Song Yajun , Yang Ruifu , Zhang Xianglilan , Cui Yujun , Guo Xuejun
Published: June 2023

The presence of
V. parahaemolyticus
in migratory birds' fecal samples implies that the human pathogenic
V. parahaemolyticus
strains may also potentially infect birds and thus pose a risk for zoonotic infection and food safety associated with re-entry into the environment. Our study firstly highlights the extra copy of tRNA as a potentially informative marker for identifying the bird-carried
V. parahaemolyticus
strains.
Continentalization of an intraoceanic arc as exemplified by the Jurassic Bonanza arc of Vancouver Island, Canada
Authors: Canil Dante , Morris Rebecca A.
Published: June 2023

We present new U-Pb zircon ages, bulk rock chemistry, and field observations for volcanic and plutonic rocks of the Jurassic Bonanza arc of Vancouver Island, Canada, a proposed southern extension of the Talkeetna arc crustal section in Alaska. Rather than a synchronous and contiguous arc crustal section, the new field and geochronological data reveal three distinct periods in the arc development, wherein the oldest, “prima” (205−195 Ma), was built upon by the youngest, “dopo” (<180 Ma), with both preserving their volcanic and plutonic sections of the upper crust. In contrast, the middle “mezza” period of arc construction (195−180 Ma) has no volcanic expression and is represented almost exclusively as plutons in the middle crust emplaced below the brittle-ductile transition, and exhumed mainly along the western and southern coast of Vancouver Island. The new data and structural interpretation refute earlier models suggesting that the deeper, more mafic rocks of the middle crust (West Coast Complex) are either restite or the crystal cumulates that form the more silicic plutonic rocks (Island Plutonic Suite) in the upper crust. Both the middle and upper plutonic components are remarkably similar to average continental crust. The growth and development of the Bonanza arc in an oceanic realm—but on a thick, pre-existing marine plateau—promoted a “continentalization” of its bulk composition within ∼10 m.y., similar to what is proposed to have occurred in Costa Rica over the same timescale.
Chondrosarcoma of the hyoid bone: a case of mistaken identity in the submandibular region
Authors: Turner Emma Burman , Taylor Robert , Thomas Ligy
Published: June 2023

We describe a case of woman in her 60s who presented with a painless mass in her left submandibular region that biopsies and imaging suggested was a pleomorphic adenoma. Intraoperative findings showed a submandibular mass originating from the hyoid bone, and subsequent histopathological examination showed a grade 2 chondrosarcoma of the hyoid bone. Chondrosarcomas in the head and neck region are uncommon and presentations in the hyoid bone are very rare with only approximately 27 previously published cases. Presentations that pose as more benign pathology can cause diagnostic dilemmas for clinicians.
Acute myopericarditis and left shoulder capsulitis following second dose of mRNA SARS-CoV-2 Moderna vaccination
Authors: Quinodoz Adrien , Luthi Francois , Revaz Sylvie , Konzelmann Michel
Published: June 2023

Vaccination against mRNA SARS-CoV-2 has been administered on a very large scale and various side effects have been described. The increased risk of myopericarditis is known, and only a few cases of shoulder capsulitis have been reported after vaccination. These two pathologies have never been reported in the same patient after vaccination. Our article presents the history of a man in his 40s who presented with myopericarditis a few days after vaccination against SARS-CoV-2 with mRNA(Messenger RNA) Moderna® vaccine and who at the same time developed shoulder capsulitis. His cardiovascular symptoms resolved rapidly, and his shoulder symptoms improved/resolved within 1 year. This case should make physicians aware of the possibility of several concomitant side effects following vaccination against SARS-CoV-2.
Use and persistence of single and multiple inhaler triple therapy prescribed for patients with COPD in France: a retrospective study on THIN database (OPTI study)
Authors: Deslee Gaétan , Fabry-Vendrand Caroline , Poccardi Nolwenn , Thabut Gabriel , Eteve Pitsaer Caroline , Coriat Adrien , Renaudat Charlotte , Maguire Andrew , Pinto Thomas
Published: June 2023

Introduction

From 2018 single inhaler triple therapy (SITT) became available in France to treat moderate-to-severe chronic obstructive pulmonary disease (COPD). Given its simplified inhaler use compared with multiple inhaler triple therapy (MITT), this therapeutic option has the potential to offer benefit in terms of improved persistence and adherence. Given the lack of real-world evidence of the effectiveness of triple therapy, this study was designed to evaluate the use of MITT and SITT in France and compare persistence.

Methods

A retrospective cohort study was performed. Patients with COPD who initiated triple therapy between 1 July 2017 and 31 December 2019 were included from The Health Improvement Network, a large electronic medical database in France, which includes pharmacy data. A 60-day treatment gap defined discontinuation and thereby persistence.

Results

A total of 3134 patients initiated triple therapy for COPD in the study period, among them 485 with SITT. In 2019, the rate of use of SITT was 28.2%. The mean age (67.3 years) and sex (44.2% female) of patients initiating triple therapy was similar between MITT and SITT, and most patients had escalated from dual therapy (84.1%). However, SITT was more frequently initiated by a pulmonologist (59.8%) and a higher prevalence of comorbid asthma was observed for SITT (47.0% vs 37.9%). Persistence was assessed among patients who did not discontinue after a single dispensation of triple therapy (n=1674). Median persistence was 181 days for SITT and 135 days for MITT, and the covariate-adjusted HR for persistence was 1.47 (p<0.001) and the estimated persistence at 1 year was 33% for SITT compared with 18% for MITT.

Discussion

This study suggests that persistence was higher for the patients treated with SITT compared with MITT in France. Moreover, most patients initiated with triple therapy were previously treated with dual therapy and had exacerbations in the previous year.
Understanding the effectiveness of different exercise training programme designs on V̇O2peakin COPD: a component network meta-analysis
Authors: Ward Thomas JC , Plumptre Charles D , Fraser-Pye Alessandra V , Dolmage Thomas E , Jones Amy V , Trethewey Ruth , Latimer Lorna , Singh Sally J , Lindley Martin R , Steiner Michael C , Evans Rachael A
Published: June 2023

Pulmonary rehabilitation programmes including aerobic training improve cardiorespiratory fitness in patients with COPD, but the optimal programme design is unclear. We used random effects additive component network meta-analysis to investigate the relative effectiveness of different programme components on fitness measured by V̇O2peakin COPD. The included 59 studies involving 2191 participants demonstrated that V̇O2peakincreased after aerobic training of at least moderate intensity with the greatest improvement seen following high intensity training. Lower limb aerobic training (SMD 0.56 95% CI 0.32;0.81, intervention arms=86) and the addition of non-invasive ventilation (SMD 0.55 95% CI 0.04;1.06, intervention arms=4) appeared to offer additional benefit but there was limited evidence for effectiveness of other exercise and non-exercise components.
STRASSE: a silicon tracker for quasi-free scattering measurements at the RIBF
Authors: Liu H. N. , Flavigny F. , Baba H. , Boehmer M. , Bonnes U. , Borshchov V. , Doornenbal P. , Ebina N. , Enciu M. , Frotscher A. , Gernhäuser R. , Girard-Alcindor V. , Goupillière D. , Heuser J. , Kapell R. , Kondo Y. , Lee H. , Lehnert J. , Matsui T. , Matta A. , Nakamura T. , Obertelli A. , Pohl T. , Protsenko M. , Sasano M. , Satou Y. , Schmidt C. J. , Schünemann K. , Simons C. , Sun Y. L. , Tanaka J. , Togano Y. , Tomai T. , Tymchuk I. , Uesaka T. , Visinka R. , Wang H. , Wienholtz F.
Published: June 2023

Silicon Tracker for RAdioactive nuclei Studies at SAMURAI Experiments is a new detection system under construction for quasi-free scattering (QFS) measurements at 200–250 MeV/nucleon at the RIBF facility of the RIKEN Nishina Center. It consists of a charged-particle silicon tracker coupled with a dedicated thick liquid hydrogen target (up to 150-mm long) in a compact geometry to fit inside large scintillator or germanium arrays. Its design was optimized for two types of studies using QFS: missing-mass measurements and in-flight prompt $$\gamma $$
γ
-ray spectroscopy. This article describes (i) the resolution requirements needed to go beyond the sensitivity of existing systems for these two types of measurements, (ii) the conceptual design of the system using detailed simulations of the setup and (iii) its complete technical implementation and challenges. The final tracker aims at a sub-mm reaction vertex resolution and is expected to reach a missing-mass resolution below 2 MeV in $$\sigma $$
σ
for (p, 2p) reactions when combined with the CsI(Na) CATANA array.
Exclusive photoproduction of $$B_{c}^{\pm }$$ and bottomonia pairs
Authors: Andrade Sebastián , Siddikov Marat , Schmidt Iván
Published: June 2023

In this paper we analyze the photoproduction of heavy quarkonia pairs which include b-quarks, such as $$B_{c}^{+}B_{c}^{-}$$

B

c

+

B

c

-

-mesons or charmonium-bottomonium pairs. Compared to charmonia pair production, these channels get contributions only from some subsets of diagrams, and thus allow for a better theoretical understanding of different production mechanisms. In contrast to the production of hidden-flavor quarkonia, for the production of $$B_{c}$$

B
c

-meson pairs there are no restrictions on internal quantum numbers in the suggested mechanisms. Using the Color Glass Condensate approach, we estimated numerically the production cross-sections in the kinematics of the future electron–hadron colliders and the ultraperipheral collisions at LHC. We found that the production of $$J/\psi \,\eta _{c}$$

J
/
ψ

η
c

and $$B_{c}^{+}B_{c}^{-}$$

B

c

+

B

c

-

meson pairs are the most promising channels for studies of quarkonia pair production.
Higgs pt distribution in Higgs + jet production at hadron colliders within the noncommutative effective standard model
Authors: Gadja Mohamed El Arebi , Khodja Lamine , Delenda Yazid
Published: June 2023

We use the noncommutative Higgs effective standard model to make a phenomenological prediction for the transverse momentum distribution of the Higgs boson produced in association with a jet at hadron colliders. We calculate at leading order in the noncommutative parameter [Formula: see text] as well as leading order in the strong coupling [Formula: see text], the one-loop [Formula: see text] distribution of the Higgs boson. As in the standard model, the fixed-order distribution suffers from large logarithms at small [Formula: see text] which require an all-orders resummation. We find that the large-[Formula: see text] region of the distribution is strongly affected by the non-commutativity, while small-[Formula: see text] region is not. Following this observation, we propose a simple matching method that allows us to compute a result that is also valid at small [Formula: see text] obtained with standard-model parton showers such as Pythia 8. We also compare our results with the next-to-leading order (NLO) and next-to-next-to-leading order (NNLO) distributions in the standard model, in order to assess the importance of higher-order effects in the search for non-commutativity at colliders.
An Efficient Method for Video Object Detection in Automatic Scoring of Physical Experimental Operations
Authors: Zeng Wenbin , Guo Jichang , Hao Luguo , Liu Jianfei
Published: June 2023

Automatic scoring of students’ physical experimental operations is a very practical application which has not been researched deeply. The common method for automatic scoring of students’ experimental operations is to infer the behavior of experimental operations through the state of experimental instruments. Video object detection is the basic task of detecting the state of experimental instruments, and the problem of missed detection or false detection in video multi-object detection is one of the main reasons leading to the error of automatic scoring results. However, existing methods of video object detection mainly improve the accuracy of the model in public datasets, which has the disadvantage of not correcting false detection while improving accuracy. Therefore, an efficient video object detection method composed of YOLOv5 and a logical reasoning post-processing method was proposed to fill this gap. We compared our method with other state-of-the-art methods on three independent datasets of physical experimental instruments. We established a pipeline for automatic scoring of students’ experimental operations, designed flow charts and state score tables of three physics experiments, and compared the automatic scoring results with the average scores of six experimental teachers. The results show that our method is more robust and efficient in this application scenario. We hope this report can promote the application of logical reasoning methods in video object detection.
A tectonic solution for the Early Cambrian palaeogeographical enigma
Authors: Keppie Duncan Fraser , Keppie John Duncan , Landing Ed
Published: June 2023

The Early Cambrian palaeogeographical enigma arises when tectonic reconstructions are made using palaeoclimatic v. palaeomagnetic data that result in possibly contradictory tropical, mid-latitude, and south polar locations for major continents. For example, NW Africa and Cadomia may have lain in a tropical zone (0° to ±30° latitude) based on the presence of archaeocyath reefs, minor evaporites, and carbonate platforms at
c.
520 Ma ± 5 Ma or, alternatively, NW Africa and Cadomia may have lain in a south polar zone (90° to 60° south latitude) based on palaeomagnetic constraints. Greater Avalonia may have evolved independently from NW Africa if a dropstone constraint implying polar latitudes at
c.
530 Ma and a palaeomagnetic constraint implying
c.
50° latitude at
c.
505 Ma are accommodated. We show here how counterclockwise rotation of Gondwana during the Cambrian about an interior axis may solve the enigma. Gondwanan apparent polar wander becomes consistent with tropical conditions inferred for NW Africa when adjusted to accommodate constraints placing the south pole near Peru for
c.
540–520 Ma. Concurrent counterclockwise rotation of Baltica and Gondwana during the Middle Cambrian may have facilitated separation of Greater Avalonia from Baltica across dextral shear zones.
Dependency Update Strategies and Package Characteristics
Authors: Javan Jafari Abbas , Costa Diego Elias , Shihab Emad , Abdalkareem Rabe
Published: June 2023

Managing project dependencies is a key maintenance issue in software development. Developers need to choose an update strategy that allows them to receive important updates and fixes while protecting them from breaking changes. Semantic Versioning was proposed to address this dilemma, but many have opted for more restrictive or permissive alternatives. This empirical study explores the association between package characteristics and the dependency update strategy selected by its dependents to understand how developers select and change their update strategies. We study over 112,000 Node Package Manager (npm) packages and use 19 characteristics to build a prediction model that identifies the common dependency update strategy for each package. Our model achieves a minimum improvement of 72% over the baselines and is much better aligned with community decisions than the npm default strategy. We investigate how different package characteristics can influence the predicted update strategy and find that dependent count, age, and release status to be the highest influencing features. We complement the work with qualitative analyses of 160 packages to investigate the evolution of update strategies. While the common update strategy remains consistent for many packages, certain events such as the release of the 1.0.0 version or breaking changes influence the selected update strategy over time.
Decent Fast-Charging Performance of Li-Ion Battery Achieved by Modifying Electrolyte Formulation and Charging Protocol
Authors: Zhang Sheng S.
Published: June 2023

In this work, two strategies have been attempted to achieve decent fast-charging performances of Li-ion batteries. The first is to combine lithium bis(fluorosulfonyl)imide (LiFSI) and dimethoxyethane (DME) into an electrolyte for high ionic conductivity of the bulk electrolyte and the electrolyte-electrode interphases, and the second is to limit charging capacity within 80% state-of-charge (SOC) for stable capacity retention by lowering charging rate without increasing total charging time in the standard constant current-constant voltage (CC-CV) charging protocol. It is found that using 5 wt% fluoroethylene carbonate (FEC) as an additive enables the hybridization of 20 wt% DME into the electrolyte without adverse effects on the initial formation cycles and ongoing cycling in terms of coulombic efficiency and reversible capacity, and adding 2 wt% LiPF6 is beneficial to reducing charge-transfer resistance and stabilizing capacity retention. As a result, decent fast-charging performances are obtained from the 200 mAh graphite/LiNi0.80Co0.15Al0.05O2 pouch cells by using a 1.2 m (molality) LiFSI 3:5:2 ethylene carbonate (EC)/ethylmethyl carbonate (EMC)/DME + 5% FEC + 2% LiPF6 electrolyte (all by wt) and a modified CC-CV charging protocol consisting of CC charging at 4 C for a total of 12 min, which is the charging time equivalent to a 5 C charging protocol.
Identification of newly synthetized proteins by mass spectrometry to understand palmitate-induced early cellular changes in pancreatic islets
Authors: Cottet-Dumoulin David , Fonseca Laura Mar , Bignard Juliette , Hanna Reine , Parnaud Géraldine , Lebreton Fanny , Bellofatto Kevin , Berishvili Ekaterine , Berney Thierry , Bosco Domenico
Published: June 2023

These results show that pancreatic rat islets cultured with palmitate mainly increase synthesis of ribosomal proteins and some proteins of the cytoskeleton. They also show a significant increase of secreted proteins involved in insulin synthesis and insulin secretion, as well as insulin itself. These data provide information to understand the mechanisms of β cell failure induced by lipotoxicity via the identification of all newly synthesized proteins in islets in response to short-term exposure to palmitate.
Core body temperature changes before sleep are associated with nocturnal heart rate variability
Authors: Bigalke Jeremy A. , Cleveland Emily L. , Barkstrom Elyse , Gonzalez Joshua E. , Carter Jason R.
Published: June 2023

Core body temperature (CBT) reductions before sleep onset coincide with increases in heart rate variability (HRV) that persist throughout the sleep period. However, the relationship between individual differences in the efficiency of presleep core temperature regulation and nocturnal heart rate variability remains equivocal. The present study reports an association between the magnitude of presleep core body temperature changes and nocturnal parasympathetic activity, highlighting overlap between thermoregulatory processes before sleep and nocturnal cardiac autonomic function.
Exercise training and BDNF injections alter amyloid precursor protein (APP) processing enzymes and improve cognition
Authors: Baranowski Bradley J. , Mohammad Ahmad , Finch Michael S. , Brown Alex , Dhaliwal Roopan , Marko Daniel M. , LeBlanc Paul J. , McCormick Cheryl M. , Fajardo Val A. , MacPherson Rebecca E. K.
Published: June 2023

Our study presents the novel findings that chronic peripheral BDNF injections result in regulation of APP processing enzymes and improved cognition to a similar extent as exercise training. These findings highlight the potential efficacy of using BDNF as a therapeutic intervention in the prevention of neurodegenerative diseases (i.e., Alzheimer’s disease). Furthermore, future evidence-based preventative or therapeutic interventions that increase BDNF and reduce BACE1 will be of value for populations that are at risk of AD.
Brief exposure to intermittent hypoxia increases erythropoietin levels in older adults
Authors: Wojan Frank , Stray-Gundersen Sten , Massoudian Sahar D. , Lalande Sophie
Published: June 2023

We previously identified the shortest intermittent hypoxia protocol necessary to increase erythropoietin levels in young adults. The objective of this study was to determine whether the same intermittent hypoxia protocol increases erythropoietin levels in older adults. Eight 4-min bouts of hypoxia, representing a hypoxic duration of 32 min at a targeted oxygen saturation of 80%, increased erythropoietin levels in older adults, suggesting that exposure to intermittent hypoxia has the potential to increase oxygen-carrying capacity in an aging population.
Design of Novel Ultrabroadband Printed Antenna and Its Efficient Optimization Using Self-Adaptive Hybrid Differential Evolution Algorithm
Authors: Gao Tian-Ye , Jiao Yong-Chang , Zhang Yi-Xuan
Published: June 2023

A novel compact ultra-broadband-modified fork-shaped printed antenna is optimized efficiently by using a self-adaptive hybrid differential evolution (SHDE) algorithm. Firstly, a novel compact ultra-broadband-modified fork-shaped printed antenna structure is proposed. The antenna with more compact size consists of a modified fork-shaped radiator and a modified ground plane, which can cover a very wide operating frequency band. The antenna is fed by a step-shaped microstrip line, and the modified ground plane consists of some rectangular slots and an L-shaped stub. Then, the SHDE algorithm is used to determine structural dimensions of the proposed antenna, and the antenna’s performance is optimized while maintaining a cost-effective computation time. The optimized antenna with only

11.8
 
mm
×
19.7
 
mm

size covers -10 dB reflection coefficient bandwidth of 147.6% from 3.08 to 20.46 GHz. Finally, the antenna prototype is fabricated, and the measured results basically agree with the simulated ones. The proposed antenna can be viewed as an excellent candidate for realizing ultrabroadband transmission technology.
Larvicidal Activities of Allium sativum L. and Zingiber officinale Rosc. Extracts against Filariasis Vectors in Hadiya Zone, Ethiopia
Authors: Assemie Anmut , Gemeda Temam
Published: June 2023

Mosquitoes present an immense threat to millions of people worldwide and act as vectors for filariasis disease. The objective of the study was to determine the effect of Allium sativum and Zingiber officinale extracts against filariasis vectors. The larvae were collected from the breeding site by using standard procedures for identification and larvicidal activities. Twenty grams (20 g) from each (Allium sativum and Zingiber officinale) were extracted separately by aqueous, ethanol, and methanol solvents. The phytochemical analysis was determined in the crude sample by using standard methods. Then, larvicidal effects were determined by introducing 10 larvae of the vectors to the concentrations of 250 ppm, 500 ppm, and 750 ppm of the crude sample, and data were subjected to probit analysis to determine the LC50 and Chi‐squared test to check the significance of the mortality by R software. Anopheles funestus, Anopheles gambiae s.l., Anopheles pharoensis, Culex antennatus, and Culex quinquefasciatus were the filariasis vectors identified during the study period. The presence of phytochemical tests such as anthraquinones, flavonoids, glycosides, phenol, saponin, steroids, tannin, and terpenes was obtained. The larvicidal effects of the selected plant extracts ranged from 0%‐100%. The lowest LC50 (53 ppm) was observed for A. sativum methanol test extract against Cx. quinquefasciatus. Ethanol extracts of A. sativum have a significant effect on An. funestus (X2 = 7.5, p = 0.02352) and Cx. quinquefasciatus (X2 = 10.833, p = 0.0.0044), whereas aqueous extracts have a significant effect only on An. gambiae s.l. (X2 = 7.0807, p = 0.029. Ethanol extracts of Z. officinale have a significant effect only on the mortality of An. pharoensis (X2 = 7.0807, p = 0.029), but methanol and aqueous extracts have no significant effect against filariasis vectors. In conclusion, A. sativum have a high toxic effect than Z. officinale extract against filariasis vectors in all type of solvents. So using those plant extracts is the best to reduce the risk of the synthetic chemical on nontarget organisms and the environment, in addition to the control of mosquito‐borne diseases, but further studies will be conducted to evaluate the toxicity at different stages of the vectors.
Supplemental Table 4 from Measurement of Ovarian Tumor Immune Profiles by Multiplex Immunohistochemistry: Implications for Epidemiologic Studies
Authors: Hathaway Cassandra A. , Conejo-Garcia Jose R. , Fridley Brooke L. , Rosner Bernard , Saeed-Vafa Daryoush , Moran Segura Carlos , Nguyen Jonathan V. , Hecht Jonathan L. , Sasamoto Naoko , Terry Kathryn L. , Tworoger Shelley S. , Townsend Mary K.
Published: June 2023

Supplemental Table 4 shows beta binomial models, odds ratios and 95% confidence intervals for marker positivity in the tumor, by tumor and participant characteristics
Supplemental Table 3 from Measurement of Ovarian Tumor Immune Profiles by Multiplex Immunohistochemistry: Implications for Epidemiologic Studies
Authors: Hathaway Cassandra A. , Conejo-Garcia Jose R. , Fridley Brooke L. , Rosner Bernard , Saeed-Vafa Daryoush , Moran Segura Carlos , Nguyen Jonathan V. , Hecht Jonathan L. , Sasamoto Naoko , Terry Kathryn L. , Tworoger Shelley S. , Townsend Mary K.
Published: June 2023

Supplemental Table 3 shows case characteristics included on tissue microarrays in NHS and NHSII
Supplemental Table 2 from Measurement of Ovarian Tumor Immune Profiles by Multiplex Immunohistochemistry: Implications for Epidemiologic Studies
Authors: Hathaway Cassandra A. , Conejo-Garcia Jose R. , Fridley Brooke L. , Rosner Bernard , Saeed-Vafa Daryoush , Moran Segura Carlos , Nguyen Jonathan V. , Hecht Jonathan L. , Sasamoto Naoko , Terry Kathryn L. , Tworoger Shelley S. , Townsend Mary K.
Published: June 2023

Supplemental Table 2 shows the distribution of presence/absence of percentage of the marker in the tumor, by age of sample for type I and type II tumors
Supplemental Table 7 from Nitrated Polycyclic Aromatic Hydrocarbon (Nitro-PAH) Signatures and Somatic Mutations in Diesel Exhaust-Exposed Bladder Tumors
Authors: Gonzalez Nicole , Rao Nina , Dean Michael , Lee Donghyuk , Hurson Amber N. , Baris Dalsu , Schwenn Molly , Johnson Alison , Prokunina-Olsson Ludmila , Friesen Melissa C. , Zhu Bin , Rothman Nathaniel , Silverman Debra T. , Koutros Stella
Published: June 2023

Cosine similarities for all signatures
Supplementary Table 8 from Associations between MICA and MICB Genetic Variants, Protein Levels, and Colorectal Cancer: Atherosclerosis Risk in Communities (ARIC)
Authors: Wang Shuo , Onyeaghala Guillaume C. , Pankratz Nathan , Nelson Heather H. , Thyagarajan Bharat , Tang Weihong , Norby Faye L. , Ugoji Chinenye , Joshu Corinne E. , Gomez Christian R. , Couper David J. , Coresh Josef , Platz Elizabeth A. , Prizment Anna E.
Published: June 2023

Supplemental Table 8 shows the associations of pre-selected SNPs with Visit 2 sMICA and sMICB levels and CRC risk without adjustment for ancestry markers.
Supplemental Table 2 from Nitrated Polycyclic Aromatic Hydrocarbon (Nitro-PAH) Signatures and Somatic Mutations in Diesel Exhaust-Exposed Bladder Tumors
Authors: Gonzalez Nicole , Rao Nina , Dean Michael , Lee Donghyuk , Hurson Amber N. , Baris Dalsu , Schwenn Molly , Johnson Alison , Prokunina-Olsson Ludmila , Friesen Melissa C. , Zhu Bin , Rothman Nathaniel , Silverman Debra T. , Koutros Stella
Published: June 2023

study characteristics
Supplementary Table 6 from Associations between MICA and MICB Genetic Variants, Protein Levels, and Colorectal Cancer: Atherosclerosis Risk in Communities (ARIC)
Authors: Wang Shuo , Onyeaghala Guillaume C. , Pankratz Nathan , Nelson Heather H. , Thyagarajan Bharat , Tang Weihong , Norby Faye L. , Ugoji Chinenye , Joshu Corinne E. , Gomez Christian R. , Couper David J. , Coresh Josef , Platz Elizabeth A. , Prizment Anna E.
Published: June 2023

Supplemental Table 6 shows the associations of sMICA and sMICB levels (continuous variables) and pre-selected SNPsb with risk of CRC and subtypes of CRC.
Supplementary Table 3 from Low-Carbohydrate Diet Score and the Risk of Colorectal Cancer: Findings from the Singapore Chinese Health Study
Authors: Yu Yi-Chuan , Paragomi Pedram , Jin Aizhen , Wang Renwei , Schoen Robert E. , Koh Woon-Puay , Yuan Jian-Min , Luu Hung N.
Published: June 2023

Supplementary Table S3 describes results from models without BMI variable adjustment (overall)
Supplementary Table 4 from Associations between MICA and MICB Genetic Variants, Protein Levels, and Colorectal Cancer: Atherosclerosis Risk in Communities (ARIC)
Authors: Wang Shuo , Onyeaghala Guillaume C. , Pankratz Nathan , Nelson Heather H. , Thyagarajan Bharat , Tang Weihong , Norby Faye L. , Ugoji Chinenye , Joshu Corinne E. , Gomez Christian R. , Couper David J. , Coresh Josef , Platz Elizabeth A. , Prizment Anna E.
Published: June 2023

Supplemental Table 4 shows the associations of Visit 2 sMICA and sMICB levels (in quartiles) with CRC risk.
Supplementary Table 2 from Associations between MICA and MICB Genetic Variants, Protein Levels, and Colorectal Cancer: Atherosclerosis Risk in Communities (ARIC)
Authors: Wang Shuo , Onyeaghala Guillaume C. , Pankratz Nathan , Nelson Heather H. , Thyagarajan Bharat , Tang Weihong , Norby Faye L. , Ugoji Chinenye , Joshu Corinne E. , Gomez Christian R. , Couper David J. , Coresh Josef , Platz Elizabeth A. , Prizment Anna E.
Published: June 2023

Supplemental Table 2 shows the associations between pre-selected SNPs and Visit 2 sMICA and sMICB levels (continuous variables) stratified by sex, race, or diabetes status.
Supplementary Table S4 from COVID-19 Outcomes by Cancer Status, Site, Treatment, and Vaccination
Authors: Salvatore Maxwell , Hu Miriam M. , Beesley Lauren J. , Mondul Alison M. , Pearce Celeste Leigh , Friese Christopher R. , Fritsche Lars G. , Mukherjee Bhramar
Published: June 2023

Logistic regression odds ratios (95% CI) for COVID-19 outcomes by chemotherapy treatment (without hematologic malignancy patients).
Supplementary Materials and Methods from COVID-19 Outcomes by Cancer Status, Site, Treatment, and Vaccination
Authors: Salvatore Maxwell , Hu Miriam M. , Beesley Lauren J. , Mondul Alison M. , Pearce Celeste Leigh , Friese Christopher R. , Fritsche Lars G. , Mukherjee Bhramar
Published: June 2023

Additional description of methods including derivation of analytic cohort, description of the neighborhood disadvantage index, and additional details of statistical analyses for transparency, replicability, and reproducibility.
Supplementary Figure S9 from COVID-19 Outcomes by Cancer Status, Site, Treatment, and Vaccination
Authors: Salvatore Maxwell , Hu Miriam M. , Beesley Lauren J. , Mondul Alison M. , Pearce Celeste Leigh , Friese Christopher R. , Fritsche Lars G. , Mukherjee Bhramar
Published: June 2023

COVID-19 hospitalization among recent cancer (within three years of positive COVID-19 test; n = 6,143) and non-cancer patients (n = 41,545) who tested positive and have non-missing covariates. The results were from the model logit P(YHospitalization = 1|X, Cancer, Covariate) = β0 + βXX + βCancerCancer + βIntX × Cancer + βCovCovariate, where Covariate = Age + Race/Ethnicity + Sex + Disadvantage Index (quartile) + Comorbidity Score. Reference groups were age: 18 to 35, sex: female, BMI: 18.5 to 25, race: white/non-Hispanic, smoking status: never. A unit change in the continuous age variable is 10 years. The comorbidity score ranges from 0 to 6 and is the sum of indicators for presence of six categories of preexisting conditions in the electronic health record.
Supplementary Figure S8 from COVID-19 Outcomes by Cancer Status, Site, Treatment, and Vaccination
Authors: Salvatore Maxwell , Hu Miriam M. , Beesley Lauren J. , Mondul Alison M. , Pearce Celeste Leigh , Friese Christopher R. , Fritsche Lars G. , Mukherjee Bhramar
Published: June 2023

Severe COVID-19 among recent cancer (within three years of positive COVID-19 test; n = 6,143) and non-cancer patients (n = 41,545) who tested positive and have non-missing covariates. The results were from the model logit P(YSevereCOVID = 1|X, Cancer, Covariate) = β0 + βXX + βCancerCancer + βIntX × Cancer + βCovCovariate, where Covariate = Age + Race/Ethnicity + Sex + Disadvantage Index (quartile) + Comorbidity Score. Reference groups were age: 18 to 35, sex: female, BMI: 18.5 to 25, race: white/non-Hispanic, smoking status: never. A unit change in the continuous age variable is 10 years. The comorbidity score ranges from 0 to 6 and is the sum of indicators for presence of six categories of preexisting conditions in the electronic health record.
Supplementary Figure S7 from COVID-19 Outcomes by Cancer Status, Site, Treatment, and Vaccination
Authors: Salvatore Maxwell , Hu Miriam M. , Beesley Lauren J. , Mondul Alison M. , Pearce Celeste Leigh , Friese Christopher R. , Fritsche Lars G. , Mukherjee Bhramar
Published: June 2023

COVID-19 ICU admission among cancer (n = 12,995) and non-cancer patients (n = 34,693) who tested positive and had non-missing covariates. The results were from the model logit P(YICU = 1|X, Cancer, Covariate) = β0 + βXX + βCancerCancerStatus + βIntX × CancerStatus + βCovCovariate, where Covariate = Age + Race/Ethnicity + Sex + Disadvantage Index (quartile) + Comorbidity Score. Reference groups were age: 18 to 35, sex: female, BMI: 18.5 to 25, race: white/non-Hispanic, smoking status: never. A unit change in the continuous age variable is 10 years. The comorbidity score ranges from 0 to 6 and is the sum of indicators for presence of six categories of preexisting conditions in the electronic health record.
Supplementary Figure S6 from COVID-19 Outcomes by Cancer Status, Site, Treatment, and Vaccination
Authors: Salvatore Maxwell , Hu Miriam M. , Beesley Lauren J. , Mondul Alison M. , Pearce Celeste Leigh , Friese Christopher R. , Fritsche Lars G. , Mukherjee Bhramar
Published: June 2023

COVID-19 hospitalization among cancer (n = 12,995) and non-cancer patients (n = 34,693) who tested positive and had non-missing covariates. The results were from the model logit P(YHospitalization = 1|X, Cancer, Covariate) = β0 + βXX + βCancerCancerStatus + βIntX × CancerStatus + βCovCovariate, where Covariate = Age + Race/Ethnicity + Sex + Disadvantage Index (quartile) + Comorbidity Score. Reference groups were age: 18 to 35, sex: female, BMI: 18.5 to 25, race: white/non-Hispanic, smoking status: never. A unit change in the continuous age variable is 10 years. The comorbidity score ranges from 0 to 6 and is the sum of indicators for presence of six categories of preexisting conditions in the electronic health record.
Supplementary Figure S5 from COVID-19 Outcomes by Cancer Status, Site, Treatment, and Vaccination
Authors: Salvatore Maxwell , Hu Miriam M. , Beesley Lauren J. , Mondul Alison M. , Pearce Celeste Leigh , Friese Christopher R. , Fritsche Lars G. , Mukherjee Bhramar
Published: June 2023

Severe COVID-19 among cancer (n = 12,995) and non-cancer patients (n = 34,693) who tested positive and had non-missing covariates. The results were from the model logit P(YSevereCOVID = 1|X, Cancer, Covariate) = β0 + βXX + βCancerCancer + βIntX × Cancer + βCovCovariate, where Covariate = Age + Race/Ethnicity + Sex + Disadvantage Index (quartile) + Comorbidity Score. Reference groups were age: 18 to 35, sex: female, BMI: 18.5 to 25, race: white/non-Hispanic, smoking status: never. A unit change in the continuous age variable is 10 years. The comorbidity score ranges from 0 to 6 and is the sum of indicators for presence of six categories of preexisting conditions in the electronic health record.
Supplementary Figure S4 from COVID-19 Outcomes by Cancer Status, Site, Treatment, and Vaccination
Authors: Salvatore Maxwell , Hu Miriam M. , Beesley Lauren J. , Mondul Alison M. , Pearce Celeste Leigh , Friese Christopher R. , Fritsche Lars G. , Mukherjee Bhramar
Published: June 2023

An UpSet diagram showing the distribution of cancer treatment patterns among COVID-19 positive individuals with cancer (n = 13,752). Treatment-based analyses were performed using three mutually exclusive categories: chemotherapy (n = 2,910), radiation only (n = 690), and surgery only (n = 172). Treatment was defined according to Table S2.
Supplementary Figure S2 from COVID-19 Outcomes by Cancer Status, Site, Treatment, and Vaccination
Authors: Salvatore Maxwell , Hu Miriam M. , Beesley Lauren J. , Mondul Alison M. , Pearce Celeste Leigh , Friese Christopher R. , Fritsche Lars G. , Mukherjee Bhramar
Published: June 2023

Flowcharts describing the definitions of outcomes (panel A) and vaccination status (panel B).
Supplementary Figure S10 from COVID-19 Outcomes by Cancer Status, Site, Treatment, and Vaccination
Authors: Salvatore Maxwell , Hu Miriam M. , Beesley Lauren J. , Mondul Alison M. , Pearce Celeste Leigh , Friese Christopher R. , Fritsche Lars G. , Mukherjee Bhramar
Published: June 2023

COVID-19 ICU admission among recent cancer (within three years of positive COVID-19 test; n = 6,143) and non-cancer patients (n = 41,545) who tested positive and have non-missing covariates. The results were from the model logit P(YICU = 1|X, Cancer, Covariate) = β0 + βXX + βCancerCancer + βIntX × Cancer + βCovCovariate, where Covariate = Age + Race/Ethnicity + Sex + Disadvantage Index (quartile) + Comorbidity Score. Reference groups were age: 18 to 35, sex: female, BMI: 18.5 to 25, race: white/non-Hispanic, smoking status: never. A unit change in the continuous age variable is 10 years. The comorbidity score ranges from 0 to 6 and is the sum of indicators for presence of six categories of preexisting conditions in the electronic health record.
Supplementary Figure S1 from COVID-19 Outcomes by Cancer Status, Site, Treatment, and Vaccination
Authors: Salvatore Maxwell , Hu Miriam M. , Beesley Lauren J. , Mondul Alison M. , Pearce Celeste Leigh , Friese Christopher R. , Fritsche Lars G. , Mukherjee Bhramar
Published: June 2023

Flowchart describing derivation of COVID-19 tested analytic cohort from raw COVID-19 tested data.
Supplemental Table 1 from Five-year Survival Trends for Young Adult Cancers Diagnosed from 2002 to 2014 in Taiwan and the United States
Authors: Tsai Yu-Han , Teng Yu-Tung , Kuan Tai-Chuan , Liu Jason J.
Published: June 2023

APC values for five-year age-standardized relative survival trends with more than one joinpoint segment
Supplementary Table 1 from Survival of Middle Eastern and North African Individuals Diagnosed with Colorectal Cancer: A Population-Based Study in California
Authors: Zaki Timothy A. , Ziogas Argyrios , Chang Jenny , Murphy Caitlin C. , Anton-Culver Hoda
Published: June 2023

Supplementary Table 1 provides treatment quality metrics for colon and rectal cancers using adherence to National Comprehensive Cancer Network guidelines.
Supplementary Table 9 from Somatic Mosaic Chromosomal Alterations and Death of Cardiovascular Disease Causes among Cancer Survivors
Authors: Sun Maxine , Cyr Marie-Christyne , Sandoval Johanna , Lemieux Perreault Louis-Philippe , Busque Lambert , Tardif Jean-Claude , Dubé Marie-Pierre
Published: June 2023

Supplementary Table 9: The effect of mosaic loss of Y chromosome on death of cardiovascular disease causes, coronary artery disease causes, from cancer and any cause of death
Supplementary Table 7 from Somatic Mosaic Chromosomal Alterations and Death of Cardiovascular Disease Causes among Cancer Survivors
Authors: Sun Maxine , Cyr Marie-Christyne , Sandoval Johanna , Lemieux Perreault Louis-Philippe , Busque Lambert , Tardif Jean-Claude , Dubé Marie-Pierre
Published: June 2023

Supplementary Table 7: The effect of autosomal mosaic chromosomal alterations on death of cardiovascular disease causes, coronary artery disease causes, from cancer and any cause of death
Supplementary Table 2 from Somatic Mosaic Chromosomal Alterations and Death of Cardiovascular Disease Causes among Cancer Survivors
Authors: Sun Maxine , Cyr Marie-Christyne , Sandoval Johanna , Lemieux Perreault Louis-Philippe , Busque Lambert , Tardif Jean-Claude , Dubé Marie-Pierre
Published: June 2023

Supplementary Table 2: ICD-9 and ICD-10 diagnostic and procedure codes for inpatient cardiovascular-related endpoints and for the primary endpoints
Table S9 from Exploring the Complex Relationship between Gut Microbiota and Risk of Colorectal Neoplasia Using Bidirectional Mendelian Randomization Analysis
Authors: Li Wanxin , Zhou Xuan , Yuan Shuai , Wang Lijuan , Yu Lili , Sun Jing , Chen Jie , Xiao Qian , Wan Zhongxiao , Zheng Ju-Sheng , Zhang Cai-Xia , Larsson Susanna C. , Farrington Susan M. , Law Philip , Houlston Richard S. , Tomlinson Ian , Ding Ke-Feng , Dunlop Malcolm G. , Theodoratou Evropi , Li Xue
Published: June 2023

Table S9 shows the reverse MR analyses of colorectal cancer, adenoma and polyps with the abundance of nine gut microbiota.
Supplementary Table 16 from Somatic Mosaic Chromosomal Alterations and Death of Cardiovascular Disease Causes among Cancer Survivors
Authors: Sun Maxine , Cyr Marie-Christyne , Sandoval Johanna , Lemieux Perreault Louis-Philippe , Busque Lambert , Tardif Jean-Claude , Dubé Marie-Pierre
Published: June 2023

Supplementary Table 16: Cox regression analyses for the effect of mosaic chromosomal alterations on the risk of incident cardiovascular endpoints aged ≥65 years old (n=15,273)
Table S8 from Exploring the Complex Relationship between Gut Microbiota and Risk of Colorectal Neoplasia Using Bidirectional Mendelian Randomization Analysis
Authors: Li Wanxin , Zhou Xuan , Yuan Shuai , Wang Lijuan , Yu Lili , Sun Jing , Chen Jie , Xiao Qian , Wan Zhongxiao , Zheng Ju-Sheng , Zhang Cai-Xia , Larsson Susanna C. , Farrington Susan M. , Law Philip , Houlston Richard S. , Tomlinson Ian , Ding Ke-Feng , Dunlop Malcolm G. , Theodoratou Evropi , Li Xue
Published: June 2023

Table S8 shows the forward MR analyses of the six gut microbial metabolites with the risk of colorectal cancer.
Table S7 from Exploring the Complex Relationship between Gut Microbiota and Risk of Colorectal Neoplasia Using Bidirectional Mendelian Randomization Analysis
Authors: Li Wanxin , Zhou Xuan , Yuan Shuai , Wang Lijuan , Yu Lili , Sun Jing , Chen Jie , Xiao Qian , Wan Zhongxiao , Zheng Ju-Sheng , Zhang Cai-Xia , Larsson Susanna C. , Farrington Susan M. , Law Philip , Houlston Richard S. , Tomlinson Ian , Ding Ke-Feng , Dunlop Malcolm G. , Theodoratou Evropi , Li Xue
Published: June 2023

Table S7 shows the forward MR analyses of nine gut microbiota with the risk of colorectal cancer.
Supplementary Table 13 from Somatic Mosaic Chromosomal Alterations and Death of Cardiovascular Disease Causes among Cancer Survivors
Authors: Sun Maxine , Cyr Marie-Christyne , Sandoval Johanna , Lemieux Perreault Louis-Philippe , Busque Lambert , Tardif Jean-Claude , Dubé Marie-Pierre
Published: June 2023

Supplementary Table 13: Cox regression analyses for the effect of mosaic chromosomal alterations on the risk of death of coronary artery disease causes by cancer type