bluuebunny/crossref_metadata_2025 huggingface dataset:
Faith Interactions in Osogbo, Nigeria: A Muslim Perspective
Authors: Rauf Mumini O. , Fahm AbdulGafar Olawale
Published: October 2022

This paper examines the level of religious encounters among people of diverse faiths in Osogbo. It addresses the open exchange and interrelationship of adherents of different faiths within the city as well as the level of misunderstanding that exists from a Muslim perspective. The study is historical and descriptive. It is historical in the sense that it assesses newspaper reports, oral interviews, and court records while a descriptive approach was used in analyzing all the issues related to concepts and ideas of religious encounters.  It reveals that the actions and inactions of people of other faiths in Osogbo are threats to social cohesion in the community. The study shows areas of conflict with the Muslims in Osogbo despite the open relationship among people of diverse faiths. The paper, therefore, recommends that for a good relationship to be sustained in Osogbo, there is a need for adherents of the three religions to keep off confrontational approaches and embrace dialogue and mutual understanding to promote peaceful co-existence within the community.
Taxonomic revision, occurrence, and identification of Intermediate Egret Ardea intermedia in North Queensland, Australia
Authors: Walsh Adrian , Chafer Chris
Published: October 2022

Between May and July 2021, five individual white egrets observed in Cairns, Queensland, Australia, appeared to have the physical characteristics of the nominate Intermediate Egret Ardea intermedia in non-breeding plumage, based on the mensurate bill methodology established by Cake et al. (2016). We review the taxonomic status of the Intermediate Egret complex, including A. intermedia (breeding in Asia), A. plumifera (breeding in Australia) and A. brachyrhyncha (breeding in Africa), using the species ranking criteria of Tobias et al. (2010). We subsequently performed an expanded comparative image-based morphometric analysis of the bills of 110 A. intermedia and A. plumifera from Asian and Australasian locations, including scaled digital photographic comparisons, and several multivariate and univariate analyses, as a test of taxon identification. In addition, we used Donegan’s (2018) universal effect size to determine if the taxa could be separated using only cranial–bill morphometry. The study showed a statistically significant dissimilarity in bill morphometry between the geographic populations, with five of the 55 Australian individuals being similar to A. intermedia. These analyses support our initial suspicion that the five birds at Cairns were A. intermedia, becoming the first recorded occurrence of A. intermedia in North Queensland or the eastern coast of Australia.
Анализ динамики эпидемического процесса COVID-19 в мире за неделю с 01.10.2022 г. по 07.10.2022 г.
Authors: Зимирова Анастасия , Поспелов Михаил , Иванова Александра , Дмитриева Людмила , Чумачкова Елена , Карнаухов Игорь , Щербакова Светлана , Кутырев Владимир
Published: October 2022

В обзоре представлен анализ эпидемиологической ситуации в странах мира по COVID-19, за неделю с 01.10.2022 г. по 07.10.2022 г.
La música en el Noticiario Documental (1942-1981): análisis del plano sonoro del noticiario franquista
Authors: Matas de Íscar Irene , Pérez-Borrajo Aarón
Published: October 2022

Históricamente, el discurso musical ha funcionado como uno de los ejes sobre los cuales se genera la propaganda. En la presente investigación nos centramos en el análisis de la música del Noticiario Documental como documento utilizado por el Franquismo para contribuir al adoctrinamiento de la sociedad española. Esta dimensión sonora se encuentra habitualmente relegada a un segundo plano frente al resto de elementos que componen este medio audiovisual. Por ello, en este artículo proponemos un acercamiento a la sintonía, a la música preexistente y a la música original empleadas en esta plataforma. El impacto de este material musical en la sociedad española fue tal que todavía forma parte de su imaginario colectivo. En definitiva, a través de estas tres dimensiones examinaremos el papel que jugó la música en el NO-DO, contribuyendo así a profundizar en los mecanismos empleados por el Régimen para influir en el espectador a partir del ámbito audiovisual.
Inland Empire
Authors: Calvo Gens Laura
Published: October 2022

Reseña del ensayo Inland Empire de Melissa Anderson, publicado en el año 2021 por Fireflies Press.
Contribución de José Neches al documental agrario español del franquismo (1945-1976).
Authors: Serena Rivera Natividad
Published: October 2022

Nos encontramos ante una monografía dedicada a José Neches Nicolás, estudio necesario no solo para la composición del cuadro global del documental agrario sino para la apertura de nuevos caminos y vías de investigación que amplían la Historia del Cine Español. Cada artículo ahonda, desde distintos puntos de vista y distintas metodologías de análisis, en el estudio de un aspecto específico en relación con la representación del mundo rural en el cine durante el franquismo, tratándose así de un fenómeno trasversal y complejo sobre la riqueza y pluralidad del audiovisual nechesiano.
La adaptación televisiva (feminizada): Josefina Molina y "El Camino"
Authors: Martínez Sánchez Álvaro
Published: October 2022

El objeto del presente artículo es el estudio de las convergencias y divergencias que habitan en la adaptación televisiva que lleva a cabo Josefina Molina de la novela El camino de Miguel Delibes, para poner de manifiesto una instancia autoral de mujer. A partir del concepto de transducción y de las teorías fílmicas feministas se pretende dar cuenta del diálogo entre ambas obras, con el fin de subrayar la mirada de mujer que allí opera, ahondando en las diferentes elecciones estilísticas y narratológicas empleadas por la directora.
Suburra – La serie como resultado de un proceso transmedial
Authors: López-Quesada Álvaro
Published: October 2022

Suburra – La serie (2017 – 2020) es una producción que se inspira en la novela homónima (2013) de Giancarlo De Cataldo y Carlo Bonini. La mayoría de los estudios que se realizan sobre la producción seriada son o temáticos o generalistas, Suburra es un ejemplo más de ello. Por esta razón, el objetivo de nuestro estudio es analizar el binomio novela–serie TV como resultado de una reescritura transmedial. Para limitar el análisis, nos centramos en las características literarias y en el fenómeno transmediático que propicia el despliegue de una historia en dos medios diferentes. Así, obtenemos que el relato televisivo busca mantener las cualidades literarias, que son reformuladas e, incluso, combinadas con el lenguaje fílmico.
Uji Tingkat Toleransi Salintas Padi Beras Hitam Asal Kalimantan Barat pada Fase Pembibitan
Authors: Rajagukguk Bintang Nagari , Palupi Tantri , Basuni NFN
Published: October 2022

Budi daya padi beras hitam pada lahan salin selalu akan mengalami cekaman abiotik yang dapat memengaruhi pertumbuhan tanaman. Perlu suatu upaya untuk mengatasi permasalahan tersebut dengan menanam varietas yang toleran salinitas. Padi hitam asal Kalimantan Barat belum pernah dilakukan pengujian terkait toleransinya terhadap salinitas. Penelitian ini bertujuan untuk mengamati tingkat toleransi beberapa padi beras hitam asal Kalimantan Barat terhadap cekaman salinitas pada fase pembibitan. Penelitian dilaksanakan di screen house Fakultas Pertanian Universitas Tanjungpura sejak bulan Juli hingga Agustus 2020, menggunakan rancangan petak terbagi yang terdiri atas 2 faktor perlakuan dan 3 ulangan. Faktor pertama (petak utama) adalah konsentrasi
NaCl, terdiri atas 0 dan 4.000 ppm (4 g NaCl/l setara dengan electric conductivity (EC) 6 dS/m), sedangkan faktor kedua (anak petak) adalah genotipe padi beras hitam, terdiri atas Temawang Lebuk, Lengkenat, dan Telaet yang berasal dari Kabupaten Sintang; Guna, Betung, dan Poron berasal dari Kabupaten Landak; varietas Pokkali dan IR29 sebagai pembanding toleran dan
peka. Jenis pengujian terdiri atas skoring toleransi bibit secara visual dan indeks sensitivitas terhadap cekaman salinitas. Variabel pengamatan terdiri atas tinggi bibit, jumlah anakan, panjang akar, dan nisbah pupus akar. Hasil penelitian menunjukkan bahwa genotipe Betung, Poron, dan Pokkali termasuk kategori toleran sedangkan genotipe Temawang Lebuk, Lengkenat, Telaet, Guna,
dan IR29 termasuk kategori peka. Pemberian NaCl dengan konsentrasi 4.000 ppm menyebabkan penurunan tinggi bibit sebesar 60%, jumlah anakan 65%, dan nisbah pupus akar 50%, akan tetapi meningkatkan panjang akar sebesar 50% pada genotipe yang tergolong peka. Genotipe yang tergolong toleran hanya mengalami penurunan tinggi bibit sebesar 25%.
Adolescentes con y sin enfermedad crónica: competencias emocionales y malestar emocional
Authors: Lacomba-Trejo Laura , Valero-Moreno Selene , Montoya-Castilla Inmaculada , Pérez-Marín Marián
Published: October 2022

Tener una enfermedad crónica (EC) en la adolescencia puede aumentar los síntomas ansiosos y depresivos. Las habilidades emocionales pueden amortiguar este impacto. El objetivo fue analizar la relación entre las habilidades emocionales y el malestar emocional, y observar las diferencias entre los adolescentes con y sin EC. Participaron 444 adolescentes (50% con enfermedad crónica), el 62,60% fueron mujeres y tenían entre 12 y 16 años. Se evaluaron las competencias emocionales (ESCQ; Shoeps et al., 2019) y el malestar emocional (HADS; Valero-Moreno et al., 2019). Se observaron niveles elevados de ansiedad, depresión y malestar emocional, y moderada percepción y comprensión, expresión y etiquetaje y manejo y regulación de emociones. Las mujeres y quienes tenían una EC mostraron más ansiedad, depresión y malestar emocional. Menos habilidades emocionales se asociaron con más más ansiedad, depresión y malestar emocional. La presencia de una EC es un factor de riesgo, las habilidades emocionales, de protección.
Serum interleukin-6 and interleukin-10 responses in patients after major trauma: a prospective observational two centre study
Authors: Jones M. , Hanison J. , Apreutesei R. , Allarakia B. , Namvar S. , Ramaswamy D. S. , Horner D. , Smyth L. , Body R. , Columb M. , Nirmalan M. , Nirmalan N.
Published: October 2022

Background
There is a need to develop objective risk stratification tools to define efficient care pathways for trauma patients. Biomarker-based point of care testing may strengthen existing clinical tools currently available for this purpose. The dysregulation of pro- and anti-inflammatory cytokines in the pathogenesis of organ failure is well recognised. This preliminary study was carried out to evaluate whether blood concentrations of IL-6, IL-10 and IL-6:IL-10 ratios in the early stages of the illness are significantly different in patients with worsening organ function.
Methods
In this prospective observational cohort study, serum concentrations of IL-6 and IL-10 on days 1, 3 and 5 were measured in 91 major trauma patients using cytometric bead arrays. A composite measure of adverse outcome - defined as SOFA ≥ 2 or mortality at 7 days, was the primary outcome. IL-6 and IL-10 concentrations in early samples (days 1, 3 & 5) in patients who developed SOFA ≥ 2 on day 7 were compared against those who did not. Comparing cytokine concentrations against similar composite outcome groups at day 5 and in groups with worsening or improving SOFA scores (ΔSOFA) at Days 7 and 5 was undertaken as secondary analyses.
Results
On day 7, 44 (48 %) patients showed adverse outcomes, associated with significantly greater IL-6 concentrations on days 1 and 5. (Day 1: 47.65 [23.24-78.68] pg/mL Vs 73.69 [39.93 – 118.07], P =0.040 and Day 5: 12.85 [5.80-19.51] pg/mL Vs 28.90 [8.78-74.08] pg/mL; P =0.0019). Similarly, IL-10 levels on days 3 and 5 were significantly greater in the adverse outcome group (Day 3: 2.54 [1.76-3.19] Vs 3.16 [2.68-4.21] pg/mL; P =0.044 and Day 5: 2.03 [1.65-2.55] Vs 2.90 [2.00-5.06] pg/mL; P <0.001). IL-6 and IL-10 concentrations were also significantly elevated in the adverse outcome groups on day 5.
Conclusions
Early IL-6 and IL-10 concentrations are significantly greater in patients who develop worsening organ functions downstream. These differences may provide an alternate biomarker-based approach to further strengthen risk stratification in trauma patients.
Adherence to commercial food thickener used for treatment of oropharyngeal dysphagia in the community. A year follow-up.
Authors: PEÑALVA-ARIGITA AMAYA , Lecha Maria , Sansano Anna , Prats Rosa , Vásquez Aida , Bascuñana Helena , Vila Lluis
Published: October 2022

Rationale:
Commercial Thickener (CT) for OD treatment is often accompanied of dislike and poor compliance.
Aim
Describe adherence of CT in our population.
Methods
Cohort prospective observational study. Randomized patients from NDU-database(4 calls-interviews/year). Variables: age, diagnostic, gender, dwelling: Home (H)/Nursing Home (NH), viscosity (nectar: N, honey: HY, pudding: P), days with CT, questionnaire answers (good, moderate, poor): use (U), consumption patterns (CP) and implementation (I) and Hidratation (H). Change in patterns (improvement, maintenance worsening) and non-adherence reasons.
Results
204pts, 82.75 ± 11.49 years; 57.8% women. Dwelling: 43.6% H/56.4% NH. Days with CT 509 ± 475.28 [0-2762]d. Viscosity in 168 pts (82.5%): N 45.2%, HY 25% and P 29.8%. A global good adherence of 50%, moderate of 20.2% and poor 29.8%. Many changes occurred in distribution throughout the study period, stressing most of changes in the moderate group (worsening changes) and less in the poor group (mainly improvement). Those with good behaviour maintained their adherence in 61%. According to dwelling, there were changes in distribution (C1-C4): In U; 43.8% vs 41% in good, 37.5% vs 17% in poor, and moderate 18.8% vs 46.3%, p = 0.001. In CP: good 37.5% vs 54.5%, poor in 46.3% vs 28.4%, and moderate 16.2% vs 17%,p = 0.04. In I; maintenance of good in 55.4% vs 63.2% poor, moderate maintenance 9.5%, p = 0.001. Also changes according to H/NH in behaviour: U; 24.4% improved vs 17.6%, 17.8%, worsen vs 45.1%, p < 0.05. CP: 42.2% improved vs 29.4% (NS), 5.5% worsen vs 33.3% (NS). I: 31.1% improved vs 15.7%, 13% worsened vs 45.1%, p < 0.01.
Conclusions
This study emphasizes the clinical relevance of adherence to CT and the need of its long term follow up.
Analysis of 2D maps based on similarity in DFT-calculated vs experimental 13 C- 15 N spin couplings for a representative sample of conformationally rigid and structurally fixed nitrogen-containing organic compounds
Authors: Stanishevskiy Vladislav V. , Shestakova Alla K. , Chertkov Vyacheslav A.
Published: October 2022

In this work, we carried out an extended verification of the 13C15N spinspin coupling constants as a new structural indicator of nitrogen-containing organic compounds. In this regard, we performed a quantum-chemical calculation (B3LYP with basis set 6-311 + + G(2df,2p)) for a representative sample of 193 spin-spin couplings for the currently known literature experimental date on them in the conformationally rigid and structurally fixed compounds. Comparison of theoretical couplings with experimental ones shows a statistically significant good to excellent agreement. A parallel analysis of the variability of the calculated values of 13C15N spin bonds with the variability of experimental data within groups of related compounds turned out to be practically useful. The approach developed can be used to quite reasonably determine the signs of spin-spin coupling constants 13C15N. It can also provide important additional information for assigning 13C peaks in cases where this cannot be done using standard NMR spectroscopy techniques.
Spatial and temporal distribution characteristics of pCO2 and CO2 evasion in karst rivers under the influence of urbanization
Authors: Li Kai , cao xingxing , Zhou Shiyu , Li Linwei
Published: October 2022

Surface rivers play an essential role in the carbon cycle processes in karst regions; however, less attention has been given to CO2 emissions from karst rivers under the influence of urbanization. In this study, we investigated CO2 partial pressures (pCO2) and degassing in a typical karst river (Nanming River and its tributaries) affected by urbanization in southwest China. Field sampling and measurements were conducted in the area from July 2021 to March 2022 in an attempt to determine the effect of urbanization on riverine pCO2 and CO2 degassing. The results showed that the average values pCO2 of the Nanming River mainstream in the wet season, dry season and flat season were 1975.77 ± 714.45 µatm, 1116.08 ± 454.24 µatm, and 976.89 ± 746.37 µatm, respectively. The tributary had three phase mean pCO2 values of 1770.46 ± 1120.79 µatm, 1638.13 ± 1121.82 µatm, and 1107.74 ± 824.03 µatm. On the whole, the pCO2 of the mainstream of the Nanming River is only slightly higher than that of the tributaries in the wet season but lower than that of the tributaries in the other two hydrological periods. The pCO2 showed obvious seasonal changes in the whole basin; it was the highest in the wet season, followed by the dry season, and the lowest in the flat season. Additionally, more than 90% of the sample points show a supersaturated state of CO2, demonstrating the carbon source characteristics. Spatially, pCO2 tends to be higher in the west region than in the east, higher in the middle than in the immediate vicinity, and higher in the south during the three seasons. And, the pCO2 responds to the urbanization gradient across different rivers and in the upper, middle and lower reaches of the river; that is, the areas with high urbanization have higher pCO2. Urban land along the Nanming River's mainstream has a weaker correlation with pCO2 than urban land along the tributaries due to the mainstream's regular management in recent years. In addition, pCO2 is also positively correlated with TP and TN, which shows that nutrient input from human activities may result in an increase in river CO2 emissions. In the Nanming River Basin, the average CO2 diffusion fluxes at the water-air interface in the wet season, dry season and flat season were 147.02 ± 100.3 mmol/(m2d), 76.02 ± 67.45 mmol/(m2d), and 119.28 ± 168.22 mmol/(m2d), respectively, and the spatiotemporal distribution characteristics were basically the same as those of pCO2. The findings of this study are on the high side when compared to the CO2 fluxes of other rivers in the globe and the worldwide average CO2 fluxes of rivers. Therefore, the impact of urbanization on the carbon emissions of karst rivers cannot be ignored, but strengthening urban river governance can reduce its carbon emissions intensity.
Medical Insurance Payment Schemes and Patient Medical Expenses: A Cross- Sectional Study of Lung Cancer Patients in Urban China
Authors: Hu Hanxu , Zhao Liying , Yong Yang , Nicholas Stephen , Maitland Elizabeth , Zhao Weihan , Yan Hao , Ma Yong , Shi Xuefeng
Published: October 2022

Background：As the main cause of cancer death, lung cancer imposes seriously health and economic burdens on individuals, families, and the health system. In China, there is no national study analyzing the hospitalization expenditures of different payment methods by lung cancer inpatients. Based on the 2010-2016 database of insured urban resident lung cancer inpatients from the China Medical Insurance Research Association (CHIRA), this paper examines the differences in hospital expenses and patient out-of-pocket (OOP) expenses under four medical insurance payment methods: fee-for-service (FFS), per-diem payments, capitation payments (CAP) and case-based payments, and then explores the medical insurance payment method most conducive to controlling the cost of lung cancer.
Method: This is a 2010-2016, 7-year cross-sectional study. CHIRA data are not available to researchers after 2016. The Medical Insurance Database of CHIRA was screened using the international disease classification system to yield 28200 inpatients diagnosed with lung cancer (ICD-10: C34, C34.0, C34.1, C34.2, C34.3, C34.8, C34.9). The study includes descriptive analysis and regression analysis based on generalized linear models (GLM).
Results： The average patient age was 63.4 years and the average length of hospital stay (ALOS) was 14.2 day; 60.7% of patients were from tertiary hospitals; and 45% were insured by FFS. The per-diem payment had the lowest hospital expenses (RMB7496.00/US$1176.87), while CAP had the lowest OOP expenses (RMB1328.18/US$208.52). Compared with FFS hospital expenses, per-diem was 21.3% lower (95% CI=-0.265, -0.215) and case-based payment was 8.4% lower (95% CI=-0.151, -0.024). Compared with the FFS, OOP expenses, per-diem payments were 9.2% lower (95% CI=-0.130, -0.063) and CAP was 15.1% lower (95% CI=-0.151, -0.024).
Conclusion：For lung cancer patients, per-diem payment generated the lowest hospital expenses, while CAP meant patients bore the lowest OOP costs. Facing major diseases such as lung cancer, priority should be given to reducing OOP expenses and implementing CAP. But policy makers should also consider case-based payments to achieve a tripartite balance among medical insurers, hospitals, and insured members. We recommend comparative future studies of the impact of medical insurance schemes on patients suffering other diseases.
Arabic translation and validation of a pediatric sleep questionnaire to assess the prevalence of sleep-disordered breathing among Saudi pre-school children
Authors: Masoud Ahmed I , Mosli Rana H
Published: October 2022

Objectives: (1) To translate to Arabic a validated pediatric sleep questionnaire, (2) To assess the validity and reliability of the translated questionnaire, and (3) To assess the prevalence of sleep-disordered breathing (SDB) among a group of pre-school children in Jeddah, Saudi Arabia.
Methods: Using forward and back-translation, a set of 6 hierarchically arranged questions that comprise the Gozal sleep questionnaire was translated into Arabic. Validity was assessed using face validity and content validity for consistency and clarity, both item-level and scale-level content validity indices (I-CVI, S-CVI). Consent forms were sent to 1783 mothers recruited from 8 different pre-schools in Jeddah between October 2017 and April 2018, and 209 signed and returned the consent forms. Out of this sample, 34 mothers were contacted to assess internal consistency using Cronbach's alpha, and test-retest reliability using Interclass correlation coefficient (ICC). Finally, all 209 mothers were contacted to answer the questionnaire to obtain the prevalence of SDB.
Results: Using face validity and content validity, the translated questionnaire proved to be valid with perfect I-CVI and S-CVI. Internal consistency (Cronbach’s Alpha 0.64–0.89) and test-retest reliability (ICC=087, p<0.001) showed the translated questionnaire to have favorable and good reliability. Depending on the severity of SDB, the prevalence of SDB was 7.7%, 5.7%, and 3.8% for mild, moderate and severe cut-off values respectively.
Conclusion: a validated pediatric sleep questionnaire to assess SDB was translated into Arabic and the translation proved to be valid and reliable. The prevalence of SDB was found to be very comparable to other areas in the world.
Ca2+ binding to Synapsin I regulates resting Ca2+ and recovery from synaptic depression in nerve terminals
Authors: Moschetta Matteo , Ravasenga Tiziana , De Fusco Antonio , Maragliano Luca , Aprile Davide , Orlando Marta , Sacchetti Silvio , Casagrande Silvia , Lignani Gabriele , Fassio Anna , Baldelli Pietro , Benfenati Fabio
Published: October 2022

Synapsin I (SynI) is a synaptic vesicle (SV)-associated phosphoprotein that modulates neurotransmission by controlling SV trafficking. The SynI C-domain contains a highly conserved ATP binding site mediating SynI oligomerization and SV clustering and an adjacent main Ca2+ binding site, whose physiological role is unexplored. Molecular Dynamics simulations revealed that the E373K point mutation irreversibly deletes Ca2+ binding to SynI, still allowing ATP binding, but inducing a destabilization of the SynI oligomerization interface. Here, we analyzed the effects of this mutation on neurotransmitter release and short-term plasticity in excitatory and inhibitory synapses from primary hippocampal neurons. Patch-clamp recordings showed an increase in the frequency of miniature excitatory postsynaptic currents (EPSCs) that was totally occluded by exogenous Ca2+ chelators and associated with a constitutive increase in resting terminal Ca2+ concentrations. Evoked EPSC amplitude was also reduced, due to a decreased readily releasable pool (RRP) size. Moreover, in both excitatory and inhibitory synapses, we observed a marked impaired recovery from synaptic depression, associated with impaired RRP refilling and depletion of the recycling pool of SVs. Our study identifies SynI as a novel Ca2+ buffer in excitatory terminals. Blocking Ca2+ binding to SynI results in higher constitutive Ca2+ levels that increase the probability of spontaneous release and disperse SVs. This causes a decreased size of the RRP and an impaired recovery from depression due to failure of SV reclustering after sustained high-frequency stimulation. The results indicate a physiological role of Ca2+ binding to SynI in the regulation of SV clustering and trafficking in nerve terminals.
Key Elements of Cellular Senescence Involve Transcriptional Repression of Mitotic and DNA Repair Genes Through the p53-p16/pRB-E2F-DREAM Complex
Authors: Pillai Renuka Kandhaya , Mur Francesc Miro , Alijotas-Reig Jaume , Tchkonia Tamar , Schwartz Simo , Kirkland James L. , Oshima Junko
Published: October 2022

Cellular senescence is a dynamic stress response process that contributes to aging. From initiation to maintanence, senescent cells continuously undergo complex molecular changes and develop an altered transcriptome. Understanding how the molecular architecture of these cells evolves to sustain their non-proliferative state will open new therapeutic avenues to allievate or delay consequences of aging. Seeking to understand these molecular changes, we studied the transcriptomic profiles of endothelial replication-induced senescence and senescence induced by the inflammatory cytokine, TNF-α. The downregulated gene signature of both replicative and TNF-α senescence were highly overlapped: decreasing expression of several genes associated to cell cycle regulation, DNA replication, recombination, repair, chromatin structure, cellular assembly, and organization. We identified multiple targets of p53/p16-pRB-E2F-DREAM that are essential for proliferation, mitotic progression, resolving DNA damage, maintaining chromatin integrity, and DNA synthesis were repressed in senescent cells. Here we provide important molecular link between DREAM repressor complex and senescence, and identify pleothra of p53/p16-pRB-E2F-DREAM targets that controls the stability of the senescenct arrest. We propose stable repression of large number of mitotic genes by p53/p16-pRB-E2F-DREAM pathway contributes to the extended mitotic arrest and permanence of the senescent state.
Effect of rotational speed and feed rate on microstructure and mechanical properties of 6061 aluminum alloy manufactured by additive friction stir deposition
Authors: chen gang , Wu Kai , Wang Yu , Zhu Zhi-Xiong , Nie Pan , Hu Feng-Feng
Published: October 2022

Additive friction stir deposition(AFSD) is attractive for its ability to create freeform and fully-dense structures without melting and solidification. Hence, additive friction stir deposition is an alternative to fusion-based additive manufacturing technology. In this study, the influence of AFSD parameter (i.e. rotational speed and feed rate) on the mechanical properties and microstructure of 6061 aluminum alloy is investigated. The as-deposited 6061 aluminum alloy exhibits relatively homogeneous microstructure with extensive equiaxed grains. Compared to the base material, the ultimate tensile strength is ranged from 320 MPa to 210MPa, decreasing to 65% of the feedstock material. The grain boundary misorientation distribution indicates that continuous dynamic recrystallization occurs during the AFSD process. Furthermore, it is evidence that the grain size and ultimate tensile strength are positive correlated with feed rate and rotational speed, whereas the elongation at break decreases with the increase in feed rate and rotational speed.
Tool wear assessment and life prediction model based on image processing and deep learning
Authors: Wu Cheng , Wang Shenlong
Published: October 2022

In the machinery field, drilling is one of the most important machining methods. Real-time monitoring of drill wear can effectively prevent the part quality from not meeting the specifications due to drill failure. This paper proposes a tool wear assessment and life prediction model based on image processing and deep learning methods, which shows great performance for small sample datasets and for low quality images. We construct an image database of drill bits and extract the normal areas and worn areas of the drill bits using the U-Net network and traditional image processing methods, respectively. Moreover, the original dataset is classified using the migration learning technique. The wear level of a drill bit can be accurately evaluated through experimental tests. Testing results show that the proposed method is more convenient and efficient than the previous methods that used manual measurements; the results can be applied to real-time drill wear monitoring, thereby reducing part damage caused by tool wear.
A Study On Conjunctival Impression Cytology in Patients with Early Multiple Sclerosis
Authors: El-Metwaly Marwa Z. , Aly Mona M. , Mohamed Jihan A. , Ali Doaa M.
Published: October 2022

Objective
The current study aims to evaluate the utility of impression cytology in the diagnosis of ocular surface alterations in multiple sclerosis patients as well as to connect impression cytology results with symptoms and clinical evaluation data.
Patients and Methods:
The study included 60 patients [120 eyes] who were divided into 3 groups: Group 1: included 20 participants (40 eyes) with early-diagnosed multiple sclerosis; group 2: included 20 participants (40 eyes) with multiple sclerosis who are already receiving treatment; and group 3: included 20 participants (40 eyes) who were randomly assigned to an age-matched control group who had no ocular or systemic pathologies. In people aged 20 to 40, an ocular tear film was evaluated. All patients finished the routine ophthalmological assessment, fluorescein tear breakup time [TBUT], Schirmer test, and conjunctival impression cytology [CIC].
Results
Most of the early group patients showed grades 1, 2 and 3 (20%, 35% and 30% respectively) in CIC results in 85% of the eyes, whilst in the chronic group patients showed grades 1, 2 and 3 (35%, 25%and 15% respectively) in CIC results in 75% of the eyes, while in the control subjects, impression cytology results showed that all cases were grade 0 (100%) with a highly statistically significant difference with P-value < 0.001. As regarding the mean scores for the TBUT and Schirmer scores for the control group patients, they were (13.7 ± 1.488s) and (13.325 ± 1.5424mm), respectively, whilst the mean scores for the TBUT and Schirmer scores for the early group patients were (7.85 ± 2.1068s) and (7.525 ± 1.9347mm), respectively, while the mean scores for the TBUT and Schirmer scores for the chronic group patients were (9.625 ± 3.3258s) and (9.8 ± 3.4877mm) with a highly statistically significant difference with a P-value < 0.001.
Conclusion
Impression cytology is a non-invasive procedure for examining ocular surface cell morphology that can be used to identify and assess the severity of conjunctival alterations in people with multiple sclerosis.
Organic-inorganic hybrid molecules for elastic ceramic plastic with covalent-ionic bicontinuous network
Authors: Liu Zhaoming , Fang Weifeng , Mu Zhao , He Yan , Kong Kangren , Jiang Kai , Tang Ruikang
Published: October 2022

Transformations of molecules to bulk materials constitute a unique direction for rational design of materials, known as bottom-up syntheses. Although organic-inorganic hybrid materials have played indispensable roles as mechanical, optical, electronic, and biomedical materials, isolated organic‒inorganic hybrid molecules (currently only limited in covalent compounds) seldom presented throughout the preparation of hybrid materials, which is due to the distinct behaviours of organic covalent bonds and inorganic ionic bonds in molecular construction. Here, we integrate typical covalent and ionic bonds within one molecule to create an organic‒inorganic hybrid molecule, which can be used for bottom-up syntheses of hybrid materials. A combination of the organic covalent thioctic acid (TA) and the inorganic ionic calcium carbonate oligomer (CCO) via an acid-base reaction provided a TA-CCO hybrid molecule, and its representative molecular formula was TA2Ca(CaCO3)2. Its dual reactivity involving co-polymerization of the organic TA-segment and inorganic CCO-segment generated the respective covalent and ionic networks. The two networks were interconnected and integrated by each TA-CCO complex to form a covalent-ionic bicontinuous structure within the resulting hybrid material, poly(TA-CCO), which synchronously achieved unification of paradoxical mechanical properties, i.e., hardness versus resilience and strength versus deformability. Moreover, the dynamic Ca2+-CO32- bonds in the ionic network and S‒S bonds in the covalent network ensured material recyclability with plastic-like mouldability while preserving thermal stability. The coexistence of ceramic-like, rubber-like and plastic-like behaviours within poly(TA-CCO) goes beyond current classifications of materials, following the generation of the “elastic ceramic plastic”. The demonstrated bottom-up creation of organic‒inorganic hybrid molecules, covalent-ionic bicontinuous networks and ultimately unique materials provides a feasible pathway for design and construction of hybrid materials by molecular engineering, thereby supplementing the classical methodology used for manufacture of organic‒inorganic hybrid materials.
Infinitely many sign-changing solutions for the nonlinear Schrödinger-Poisson system with super 2-linear growth at infinity
Authors: Wang Shuai , Wu Xing-Ping , Tang Chun-Lei
Published: October 2022

Note: Please see pdf for full abstract with equations.
In this paper, we investigate the sign-changing solutions to the following Schrödinger-Poisson system
−∆u + V (x)u + λφ(x)u = f (u), x ∈ R3 ,
−∆φ = u2 , x ∈ R3 ,
where λ > 0 is a parameter and f is super 2-linear at infinity. By using the method of invariant sets of descending flow and a multiple critical points theorem, we prove that this system possesses infinitely many sign-changing solutions for any λ > 0.
Mathematics Subject Classification. 35J20 · 35J60.
Environmental factors predict psychological symptoms in adolescent refugees during the initial post-resettlement phase
Authors: Hocking Debbie C , Sundram Suresh
Published: October 2022

Background
Adolescent refugees are at high risk of developing mental disorders but are often not recognised early. This pilot study aimed to identify early putative risk factors associated with psychological symptoms in newly resettled refugee youth at potential risk of subsequently developing mental disorders.
Methods
Newly resettled adolescent refugees were recruited through English language schools in Melbourne, Australia. Participants were assessed with the MINI-Kid, Achenbach Youth Self-Report and Reaction of Adolescents to Traumatic Stress scale. Parents completed a mental health screening separately. Linear regression models were used to identify predictive factors associated with symptom ratings.
Results
Seventy-eight, ostensibly well, refugee adolescents (mean age = 15.0 ± 1.6 years) resettled in Australia for 6.1 ± 4.2 months were assessed. Levels of anxiety, depression and post-traumatic stress symptoms were considerably lower than in mainstream population data. Prior displacement was a key determinant of symptomatology. Transitory displacement, irrespective of duration, was associated with elevated scores for depression (t(47)=-4.05, p < 0.0001), avoidance/numbing (U = 466, p < .05) and total trauma (U = 506, p < .05) symptoms. Older age was a unique predictor of depression (F (1,74) = 8.98, p < .01), internalising (F(1,74) = 6.28, p < .05) and total (F(1,74) = 4.10, p < .05) symptoms, whilst parental depression symptoms (t = 2.01, p < 0.05), displacement (t = 3.35, p < 0.01) and, expectedly, trauma exposure (t = 3.94, p < 0.001) were unique predictors of post-traumatic stress symptoms.
Conclusions
Displaced status, older age and parental symptoms predicted psychological symptoms in adolescent refugees in an initial relatively asymptomatic post-resettlement phase. The early recognition of at-risk refugee youth may provide an opportunity for preventative mental health interventions.
Flow direction for analysis of the concentration of metals in the groundwater of the Western Amazon region (Ji-Paraná/RO), Brazil
Authors: Ramos Caryne Ferreira , Laureano Josilena de Jesus , Lopes Daise Silva , Sousa Lindolaine Machado , Lima Tiago Oliveira , Gomes Beatriz Machado , Júnior Walkimar Aleixo Costa , Bastos Wanderley Rodrigues , Oliveira Robson Alves , Nascimento Maria Cristina Nery do , Rosa Ana Lúcia Denardin da , Nascimento Elisabete Lourdes do
Published: October 2022

Metals refer to one of the main and most dangerous groups of water contaminants, so this research aimed to investigate the groundwater of Dois de Abril micro basin creek regarding the presence of metals and the spatial distribution of the elements regarding the underground flow direction. To that end,15 collections were performed in wells in February, March (High Waters – AA) and September 2019 (Low Waters – AB). The samples were analyzed for 14 inorganic chemicals by means of Inductively Coupled Plasma Optical Emission spectroscopy (ICP-OES). And through the Surfer 8.0 software, the flow direction was obtained using the potentiometric surface of the tubular wells registered in the Groundwater Information System - SIAGAS. Wilcoxon and Spearman tests were applied for the discussion of the results. The averages obtained are within the Maximum Allowed Values – MAV by the national human consumption legislation, but some wells presented high values for aluminum, iron, lead and barium, due to geochemistry and geology of the region, low pH values and the use and occupation of the soil. The trend of the underground flow direction of the municipality contributes to the main river that crosses the city. The flow direction and statistical tests applied were sufficient to discuss the results.
Rosmarinic acid as a novel biomedical drug for inhibiting the replication of herpes and dengue viruses: An In-silico assessment
Authors: Rani A. Christy , Kalaimathi K. , Jayasree S. , Murugesan S , S Prabhu , Cherian Pinkie
Published: October 2022

Since ancient times to till now, viruses such as dengue, herpes virus, ebola, AIDS, influenza, ebola, chicken meat and SARS have been roaming around causing great health burdens. To fight against these contagious viruses, people rely heavily on medicinal plants to enhance their immune system of innate and adaptive. In this research, the preparation of ligands and proteins was performed using the Maestro V.13.2 module tool. This software, consisting of LigPrep, Grid Generation, SiteMap and Glide XP, has each contributed significantly to the preparation of ligands and proteins. Ultimately, the research found that (R)-(+)-rosmarinic acid was found to have significant docking scores of -10.847 for herpes virus, of -10.033 for NS5 and − 7.259 for NS1. In addition, the Pass Server prediction indicates that rosmarinic acid possesses a diverse spectrum of enzymatic activities, as Probability Active (Pa) values ​​start at > 0.751; whereas it has fewer adverse effects than the drugs prescribed for viruses. Accordingly, it was found that the rate of acute toxicity values ​​of rosamric acid. According to this analysis, we expect that the current research will reveal a clear route to finding a medicine that can successfully lessen the complications of numerous viruses without causing any harmful effects. Ultimately, we concluded that (R)-(+)-rosmarinic acid would expose significant antiviral effects in in-vitro and in-vivo experiments and also this research would be a valuable asset for future especially those who wish to discover a drug molecule for variety of viruses.
Effect of RNAi-mediated survivin and Hypoxia-inducible factor 1α gene silencing on proliferation, invasion, migration and apoptosis of gastric cancer BGC-823 cells
Authors: Yupeng Li , Mingzhu Chang , Runhong Mu , Jianyu Zhu
Published: October 2022

Objective: To investigate the effect of RNAi-mediated survivin and Hypoxia-inducible factor 1α (HIF-1α) gene silencing on proliferation and apoptosis of gastric cancer BGC-823 cells.
Methods: Small interfering RNAs (siRNAs) targeting survivin and HIF1α mRNAs were designed and synthesized, respectively, while scrambled siRNAs (SCRs) were synthesized. The hypoxia sensitive gastric cancer line BGC-823 was identified and transfected by Hifectin II in vitro under hypoxia condition. The cells transfected with siRNA-survivin, siRNA-HIF-1α and SCR were named as sis group, siH group and SCR group, respectively.The expression of survivin and HIF-1α were assessed by RT-PCR and Western blotting assay respectively. Cell apoptosis were determined by flow cytometry. Cell proliferation was measured by MTT assay. The abilities of invasion and migration were evaluated by transwell assays and wound healing assays respectively.
Results: The HIF-1α expression of BGC-823 cells increased apparently under hypoxia condition. The survivin targeting siRNA transfection decreased the expression of survivin under hypoxia condition, the combined transfection of survivin targeting siRNA and HIF-1α targeting siRNA down-regulated both the expression of survivin and HIF-1α obviously. Compared with the blank control group, the combined siRNA transfection group displayed obvious features with decreased invasion and migration ability under hypoxia, the apoptosis rate increased and the cell proliferation decreased obviously.
Conclusion: The down-regulation of survivin and HIF-1α in BGC-823 cell lines may induce an anticancer effect by enhancing cell apoptosis, and decrease the proliferation, migration and invasion ability.
Can restless legs be a sign of something else? a case of spondyloarthritis presenting with restless legs syndrome
Authors: YILMAZ Ebru
Published: October 2022

Restless legs syndrome (RLS), is a chronic movement disorder, characterized by an urge or need to move the limbs, usually associated with uncomfortable sensations in the legs and sleep disorders. Two clinical forms of RLS are described in general: primary and secondary. Although primary RLS has a familial component, the underlying mechanism is still not fully understood but seems to be related to abnormalities in the dopaminergic pathways of the central nervous system. The secondary form of the syndrome is associated with iron deficiency, renal failure, pregnancy, diabetes mellitus, peripheral neuropathy, and many rheumatologic disorders such as rheumatoid arthritis (RA) and Sjögren’s syndrome. In a few clinical trials, an increased frequency of RLS has been reported in patients with spondyloarthritis. In this report, it is presented a case of coexistence spondyloarthritis and RLS showing satisfactory improvement with conservative treatment additionally adding naproxen. Anemia of chronic disease occurring in rheumatic diseases and associated iron deficiency may contribute to the development of RLS.
Regional Tracking problem for a reaction-diffusion equation with bilinear boundary controls
Authors: ElKabouss Abella , Zerrik EL Hassan
Published: October 2022

In this paper we investigate a regional optimal control problem of a reaction-diffusion equation evolving on a spatial domain Ω ⊂ R2 where controls act in bilinear manner on the boundary ∂Ω of Ω. It addresses the tracking of a desired state all over the time interval [0, T ] only on a subregion ω of Ω with minimum energy. This may be expressed as a minimization problem of which we discuss the existence and characterization of an optimal control. Then under a sufficient condition the uniqueness of such control is established. The obtained results lead to a computational algorithm that we illustrate by a two-dimensional fish diffusion model.
Circuit Quantum Electrodynamics with Dressed States of a Superconducting Artificial Atom
Authors: Kuo Watson , Chang Yu-Han , Dubyna Demetri , Chien Wei-Chen , Chen Chien-Han , Wu Cen-Shawn
Published: October 2022

A dynamical control of the coupling strengths between dressed states and probe photon states is demonstrated with a transmon-like artificial atom coupled to two closely spaced resonant modes. When the atom is driven with one mode, the atom state and driving photon states are superposed, forming the dressed states. Dressed states with 1st, 2nd and 3rd excited states of the atom were prepared and probed via the strong coupling to the other resonant mode. Spectroscopy reveals that the coupling strengths are ``dressed" and can be modulated by the power and sideband index of the driving. The transmission of the probe tone is modulated by the driving microwave amplitude with a Bessel behavior, displaying multi-photon process associated with the inter-atomic level transitions.
Pre-treatment Body Mass Index as a Predictive Biomarker for Immunotherapy Outcomes in Advanced Lung Cancer
Authors: Tong Gangling , Chen Boran , Li Chen , Zhang Linting , Wu Xuan , Yuan Wenqing , Liu Jinying , Wang Shubin , Li Shuluan
Published: October 2022

Objectives
To analyze the clinicopathological parameters of advanced lung cancer patients who received Immune checkpoint inhibitors (ICIs) treatment to establish pre-treatment body mass index (BMI) as a predictor of immunotherapy response, patient survival, and immune-related adverse events (irAEs).
Methods
We retrospectively evaluated a cohort of 92 patients who received therapy with ICIs for advanced lung cancer at our hospital between January 2018 and January 2021. Patients were categorized into three groups based on BMI; an underweight group (BMI < 18.5 kg/m2), a normal-weight group (18.5 kg/m2 ≤ BMI ≤ 24.9 kg/m2), and an overweight group (BMI ≥ 25 kg/m2). The correlations were observed between BMI and immunotherapy response, progression-free survival (PFS), and irAEs based on ICIs treatment.
Results
Pretreatment BMI levels were significantly associated with response to ICIs therapy in disease control rate (DCR) (p = 0.034) and PFS (p = 0.006) of patients with advanced lung cancer, and it was a non-significant trend towards objective response rate (ORR) (p = 0.086). Pretreatment BMI, gender, and PD-L1 expression level were independent prognostic factors for PFS in univariate and multivariate analyses: HR = 0.323, 95% CI: 0.141–0.737, p = 0.007, and HR = 0.277, 95% CI: 0.115–0.670, p = 0.004; gender: HR = 2.609, 95% CI: 1.198–5.683, p = 0.016; PD-L1: HR = 6.599, 95% CI: 1.555–27.996, p = 0.001). Higher BMI is a significant predictor for irAEs (p = 0 .016).
Conclusion
High pre-treatment BMI is associated with positive immunotherapy outcomes, while decreased BMI was associated with irAEs development.