bluuebunny/crossref_metadata_2025 huggingface dataset:
Qui peut toucher aux cadavres ? Un conflit de modernisation dans les hôpitaux français
Authors: Boisson Marine
Published: May 2023

En France, alors que les morgues hospitalières sont critiquées dès le xixe siècle, les décès vont se concentrer dans les établissements de santé. Plus encore, un défunt sur deux passe aujourd’hui dans les chambres mortuaires des hôpitaux scientifiques. Expliquer cet apparent paradoxe exige de comprendre le travail de légitimation réalisé par des médecins et administrateurs d’hôpitaux pour conserver un contrôle sur le corps des malades tout en reconnaissant aux familles un droit de participation pour les rituels funéraires. Il devient nécessaire de rappeler les résistances qui ont fait de ces lieux un problème public local, puis national, jusqu’à ce qu’ils soient transformés. Dans cet article, nous défendons l’idée qu’un conflit de modernisation s’est opéré, depuis le xixe siècle, dans les morgues des hôpitaux pour décider du traitement appliqué au corps mort. De manière inattendue, ce conflit a débouché sur la création de chambres mortuaires dans lesquelles les morts sont, de manière potentiellement contradictoire, traités comme un matériel biologique et technique, placés sous surveillance médicale, comme des personnes défuntes dont il convient de respecter l’intégrité et la subjectivité historique. L’étude de ce conflit de modernisation permet alors de comprendre pourquoi ces services font aujourd’hui l’objet de tensions sociales, dès lors que l’un de ces deux traitements est abandonné, comme cela a pu être le cas au début de l’épidémie de Covid-19 en France.
Development of A Prostate 3D Spheroid Model for Assessing Tumor Uptake of Different Antibody Designs
Authors:   , Lewis Desmond , Shen Fei , Fatatis Alessandro
Published: May 2023

Targeted radionuclide therapy has shown improved overall survival in patients with metastatic castration resistant prostate cancer (mCRPC). Most recently, Pluvicto (177Lu-PSMA-617), a small molecule PSMA ligand conjugated to the beta emitter 177Lu was approved for treatment of mCRPC. Although, initial responses have been encouraging, further improvements are being explored outside of small molecules and beta emitters. Novel large molecule radionuclide carriers are being developed, including monoclonal antibodies and fragment-based designs that may offer unique advantages to small molecule carriers. As radionuclides are often more difficult to work with and pose a health risk if not properly trained, pre-clinical testing with cytotoxic payloads can often serve as a surrogate for radionuclide payload uptake and assessment. Conventionally, efficacy of these competing antibodies has been assessed through measuring cell viability after treatment in 2D culture conditions. The use of 2D culture allows antibodies maximal access to cells and does not measure tumor penetration, a delineating factor in vitro. As a result, full length and fragment antibody drug conjugates may appear similar in binding, internalization, and cytotoxicity. 3D spheroid culture can assess antibody penetration and recapitulate features of solid tumors more closely than 2D culture conditions. Here a C42B prostate cancer spheroid was developed to obtain a model suitable for high-throughput screening using live-cell imaging. C42B Spheroids composed of 1000 cells were found to be reproducible, having steady growth and consistent shape. The spheroids were characterized and observed to decrease in both prostate specific membrane antigen (PSMA) expression and individual cell size following the development of hypoxia, quantified by expression of HIF-1[alpha] at day seven of spheroid growth. This suggest that C42B spheroids are less sensitive to drug treatment than 2D culture due to the decrease in PSMA expression and the added penetration required in 3D culture. C42B spheroids were also observed to develop oxygen gradients resulting in hypoxia and necrosis at the core. This further validated the ability of spheroids to reproduce features of tumors not observed in 2D culture. The onset of necrosis also determined the optimal time to measure penetration of competing antibody designs. A monoclonal antibody and its digested fragment were labeled with a fluorescent dye and penetration was assessed using live-cell imaging. Spheroids treated with the competing antibodies showed a significant increase in fragment penetration compared to the full-length monoclonal antibody (P < 0.0001) over a period of 63 hours. These findings indicate that spheroids can differentiate between competing antibodies using penetration, a feature of tumors not measured using 2D culture. Spheroids allow competing antibodies to be assessed in an environment more relevant than current 2D culture conditions.
Predictors Associated with Functional Outcome in Older Adults with Brain Injury
Authors:   , Lopes Sophia , Schultheis Maria T
Published: May 2023

Background: Traumatic Brain Injury (TBI) is a major cause of death and disability in the United States. In persons aged 65 and older, TBI is responsible for more than 80,000 emergency department visits each year. Today, older adults aged 65 and older living account for more than 46 million of the U.S. population; by 2050, that number is expected to grow to almost 90 million. Research indicates that older adults have poorer outcomes than their younger counterparts after TBI and that the severity of the TBI is positively associated with the severity of functional impairment. However, other factors predicting daily functional outcomes in older adults after TBI are unclear. This systematic review seeks to synthesize the existing literature to identify factors associated with TBI functional outcomes in older adults. A comprehensive understanding of these factors and associations will better inform geriatric-based care, management, and treatment pathways to maximize favorable functional outcome in this growing population. Methods: Utilizing the Preferred Reporting Items for Systematic Reviews & Meta-Analyses- Checklist and Flowchart (PRISMA) guidelines and Covidence for management, 675 studies were screened and 14 were selected based on inclusion criteria. The following databases were used to identify studies published from January 2011 to December 2021: Pubmed, EMBASE, CINAHL, PsycInfo, and Web of Science. Only original research articles were included. The strengths and weaknesses of the studies included were also evaluated. Results: Key predictors found to be associated with functional outcome were the presence of comorbid conditions, older age, injury severity, and gender/sex. Other significant predictors of interest were emotional function and post-head injury complaints. Discussion: Older adults with greater injury severity, a higher number of comorbid conditions, female gender/sex, increasing age, or more physical or emotional complaints are at risk of unfavorable outcomes after TBI and may benefit from further screening and interventions to maximize functional outcome. Limitations in evidence include selection bias and retrospective data collection. Further research is warranted in this area with larger studies to contribute towards the formulation of geriatric-specific TBI guidelines for better management.
Преимущества организационной теории Александра Богданова в объяснении трансформации Европейского союза
Authors: Дарья Моисеева
Published: May 2023

Кризисные явления развития Европейского союза свидетельствуют как минимум о замедлениях темпов интеграции, а как максимум – о ее откате в сфере общей политики. Кажущееся отсутствие связи между этими явлениями, будь то Брекзит, европейский долговой кризис или рост популярности партий евроскептиков, способствует тому, что они изучаются изолированно, как отдельные феномены. Однако есть альтернативное видение, которые заключается в том, что все эти события представляют собой разные проявления одного процесса, а именно – трансформации политической системы Евросоюза. Трансформация подразумевает как интеграцию, так и дезинтеграцию. В данной статье организационная теория (тектология) представлена с точки зрения перспективы применения предложенных Александром Богдановым концептов для объяснения наблюдаемых процессов изменения политического пространства единой Европы. Классические теории европейской интеграции ограничены, потому что сосредоточены на изучении движущих сил интеграции, а не на том, что может повернуть интеграцию вспять. По мере политизации интеграции, роста ее влияния на повседневную жизнь европейских граждан и изменения самого Евросоюза возникает запрос на формулирование новых теоретических обоснований, способных объяснить эти изменения (в том числе кризисные). В статье проанализированы современные теоретико-методологические подходы в европейских исследованиях, включая постфункционализм. Сделан вывод об их ограниченности, которая заключается в экстенсивном расширении предметного поля. Постфункционализм, несмотря на его доминирование в европейских исследованиях, не является системной теорией, а значит, что, когда трансформация ЕС сделает очередной поворот, потребуется новая теория. Организационная теория А. Богданова, будучи системной теорией, обладает необходимым понятийно-категориальным аппаратом и потенциалом для объяснения кризисных явлений (в том числе дезинтеграции) как части большего процесса. Тектологию Богданова отличает рассмотрение (политической) системы как условно “живого” организма, способного к саморегулированию и адаптации. Такой подход к изучения демократических политических систем представляется наиболее адекватным в современных международных отношениях.
Диагностика рисков становления новой России: запрос на интегральное и суверенное знание в сфере социально-политических наук
Authors: Кравченко Сергей
Published: May 2023

Автор ставит задачу комплексной диагностики рисков, сопряженных с процессами становления новой России и анализирует возможные пути ее решения. Методологической основой исследования природы этих рисков являются теории нелинейного развития сложных систем, применяемые к анализу риск-культуры (культуры управления рисками), всего комплекса характеризующих ее ценностей, убеждений, знаний, практик оценки и осмысления рисков, включая рукотворные, инсценированные, гибридные и “стратегические”. Конкретизируя риски неуправляемой открытости российского общества в процессе перехода от однополярного к многополярному миру, автор особое внимание уделяет диагностике рисков “нового варварства”, а также рисков, грозящих ущербом национальному человеческому капиталу. Автор исходит из того, что научная диагностика предполагает не только анализ рисков, но и поиск оптимальных ответов на формируемые ими вызовы обществу. В контексте сформулированной академиком М.К. Горшковым концепции “генотипа культуры” (рассматриваемого в качестве корневой, обусловленной цивилизационно, системы нравственных ценностей и жизненных смыслов) автор выдвигает идею интеграции социально-политического, идеологического и теологического знания. По итогам исследования автор приходит к выводу, что потребность достижения гарантированного политического, экономического и технологического суверенитета России (с целью нахождения оптимальных путей воспроизводства национального человеческого капитала и формирования всесторонне развитой и социально ответственной личности современного россиянина) обуславливает движение страны по двум основным направлениям. Во-первых, по пути формирования более эффективных структур производства суверенного, национально ориентированного знания, разработки национально ориентированных теоретических концептов и соответствующего методологического инструментария исследования российского общества. А во-вторых, по пути интеграции всего многообразия культур, идейных, духовных, нравственных ценностей многонационального российского общества на основе воспроизводства генотипа российской цивилизации.
Proposal of the task-based approach in standard Chinese textbooks. Suggestions from localized didactic materials
Authors: Qiuhan Yang , García Mejías Mario , Qianchao Li
Published: May 2023

Recently the majority of theories for second language acquisition emphasize the functionof language. In the case of the Chinese language, due to its peculiarities, most of the standard textbookcontinue to be based on the synthetic syllabus, which reflects the importance of language structure.How to achieve the balance between language structure and function is a question that must beconsidered and resolved within the teaching of Chinese and the compilation of textbooks. To achievethis integration of form and meaning in standard Chinese manuals, as well as the promotion of thestudent's communicative competence, the investigation intends use the task-based approach, whichfocuses on the meaning and use of language, as a complementary method to structuralist didacticstrategies. To exemplify the application of this method, the localized textbook Camino al Chino hasbeen taken as a model, which will address the way in which the task-based approach can be introducedin the presentation, practice and production phases in a standard manual.
e·Chinese Tools: el Pan Gu de los recursos digitales para el aprendizaje y la enseñanza del chino como lengua extranjera
Authors: Rovira-Esteva Sara , Vargas-Urpí Mireia , Casas-Tost Helena , Paoliello Antonio
Published: May 2023

El uso de las tecnologías está cada vez más presente en todos los ámbitos de la vida y, por lo tanto, también lo está en el estudio de la lengua china. El empleo de herramientas digitales no solo facilita la enseñanza y el aprendizaje de esta lengua, sino que incluso en ciertos contextos está sustituyendo los modelos tradicionales de enseñanza-aprendizaje. Sin embargo, este nuevo contexto socioeducativo no está exento de dificultades, ya que a menudo resulta difícil identificar los recursos más útiles y adecuados para cada perfil de estudiante y estadio del aprendizaje, así como saber evaluar su idoneidad y calidad. Ante esta situación, consideramos necesario disponer de una herramienta para ofrecer los recursos existentes de una forma ordenada. La identificación de esta necesidad dio lugar a e·Chinese, una base de datos cuatrilingüe cuyo objetivo principal es ofrecer en acceso abierto una recopilación de recursos digitales de tipologías diferentes para la enseñanza y aprendizaje del chino. La base de datos, que está en constante actualización, ofrece una descripción sistemática de cada recurso fruto de un riguroso análisis de expertos. Así pues, en este artículo nos proponemos los siguientes objetivos: presentar el contexto que motivó la puesta en marcha de este proyecto, explicar la metodología seguida en la elaboración de la base de datos y, especialmente, en la selección, descripción y validación de los recursos incluidos, describir las principales características de e·Chinese desde el punto de vista del usuario, así como ofrecer una visión panorámica de la tipología de recursos que ofrece actualmente. A partir de los datos obtenidos, en las conclusiones reflexionaremos sobre la oferta existente, las lagunas detectadas y las nuevas tendencias, así como las posibles vías de desarrollo de materiales didácticos en la enseñanza-aprendizaje del chino.
El impacto de técnicas de enseñanza performativa del lenguaje en las habilidades orales de una clase de chino como lengua extranjera
Authors: Corderi Novoa Modesto , García Mayo María del Pilar
Published: May 2023

Este estudio investiga el impacto de las técnicas de enseñanza performativa del lenguaje (PLT) en las variables orales de fluidez, comprensibilidad y acento. 16 estudiantes de chino mandarín (L1: español) de la Escuela Oficial de Idiomas en la ciudad de Vigo en España fueron divididos en un grupo experimental (8 estudiantes que participaron en 2018 un curso de clases de chino basado en PLT de cuatro meses) y en un grupo de control (otros 8 estudiantes que no recibieron dicho curso). Se emplearon cuatro tareas diferentes (descripción de imágenes en primera persona, descripción de imágenes en tercera persona, monólogo y diálogo improvisado) para obtener muestras de habla de estos 16 estudiantes. Los dos grupos fueron evaluados antes (pre-test) y después (post-test) de su participación. 75 evaluadores chinos nativos analizaron las muestras de habla obtenidas y se compararon el desarrollo de las habilidades orales de ambos grupos. Los resultados indican que la fluidez, la comprensión y el acento mejoraron para el grupo experimental, pero no para el grupo de control. La mejora en la fluidez fue mayor que la mejora en la comprensión y el acento, que tuvieron grados de desarrollo similares, aunque el acento tuvo una mejora ligeramente menor que la comprensibilidad.
La adquisición de la metáfora conceptual en chino desde la perspectiva de la lingüística cognitiva
Authors: Lee Nong Ru Cheng
Published: May 2023

La lingüística cognitiva descubre las similitudes entre la percepción cognitiva y la percepción de las lenguas, aporta una solución a la interferencia provocada por la lengua materna en el aprendizaje de lenguas extranjeras. Este método interdisciplinar también aporta otra perspectiva al conocimiento lingüístico de los estudiantes de L2. Este trabajo trata de analizar la enseñanza de la metáfora conceptual desde la perspectiva de la lingüística cognitiva, reconstruyendo la estructura cognitiva con estrategias como “categorías”, visualizando los “esquemas de imagen”, construyendo el “modelo cognitivo”, recreando el “contexto cognitivo” y enseñando la “gramática cognitiva”, que no residen tanto en la lingüística sino en el razonamiento visual y el pensamiento lógico, de manera que aporta un enfoque diferente a la enseñanza del idioma chino.
Exotismo y recepción en las Rutas de la Seda: Dos piezas del vidrio romano halladas en las tumbas de la China antigua (ss. IV-VI d.C.)
Authors: Xiao Yang
Published: May 2023

En el mundo antiguo, China no formaba parte de los centros tradicionales en la fabricación de vidrio, un material que se consideraba raro y lujoso por los chinos de la antigüedad. A pesar de ello, en algunos yacimientos se han encontrado cierta cantidad de recipientes de vidrio cuyas características típicas demuestran su procedencia externa tanto por el análisis tipológico y el estilo decorativo, como por su composición química. El estudio del vidrio antiguo en China, sin embargo, no ha recibido suficiente atención, las investigaciones existentes sobre vidrios exóticos se centran principalmente en aspectos como su naturaleza extranjera y las rutas de introducción, y carecen de reflexiones profundas sobre los roles de China u otros países de la antigua Asia Oriental en la transmisión ulterior del vidrio, así como de una consideración exhaustiva del grado de recepción del vidrio en otro entorno cultural. Por lo tanto, en el contexto de las Rutas de la Seda entre los siglos IV y VI d.C., este trabajo toma como ejemplo las dos piezas de vidrio halladas en la Necrópolis de la Casa Feng en Jingxian (Provincia Hebei). Al examinar sus características, analizar su composición química y compararlas con ejemplares paralelos, queda claro que son típicas del Imperio Romano, ambas producidas en la costa oriental de la zona Mediterránea, y muy probablemente introducidas en China a través de las Rutas de la Estepa y que siguieron irradiando a otras partes de Asia oriental, como la península de Corea. La introducción del vidrio en China, aunque limitada en volumen y sin un impacto profundo en el país receptor, dejó su huella en la práctica religiosa y en el arte del budismo chino.
La imagen del arte chino de la dinastía Ming en el contexto español por la exposición “Arte y cultura en torno a 1492”
Authors: Jiayi Liu
Published: May 2023

Para conmemorar el 500º aniversario del descubrimiento del Nuevo Mundo por parte de Colón, la Expo 92 de Sevilla organizó una exposición titulada "Arte y cultura en torno a 1492", que presentaba obras de arte procedentes de todo el mundo del siglo XV. Este ensayo analizará los antecedentes de la exposición, sus desequilibrios en su composición, los tipos artísticos ignorados, combinando métodos estadísticos y de análisis de imágenes, para investigar la ausencia de una imagen del arte chino Ming generada por el discurso de la exposición. Al comparar la bibliografía sobre la historia del arte chino Ming con las obras de la exposición, queda claro que la imagen del arte chino construida por la exposición carece en realidad de estilos artísticos que logran mostrar luces y sombras, colores magníficos o perspectiva lineal, como, la pintura yuanti, la pintura mural y la pintura de xilografía. Estas pinturas, sin embargo, ocuparon realmente un lugar importante en el panorama artístico de la dinastía Ming. Se espera que este estudio ayude a establecer y corregir las ausencias y deficiencias en la identidad del arte chino Ming construidas por la exposición en el contexto español.
The Origin of the Concept “Tianxia” in the Political Ideological Configuration of Traditional China
Authors: Yuchen Zhang
Published: May 2023

The concept "Tianxia" (All-under-Heaven) could be a parallel concept of the "Empire" in the West, which also allows a better understanding of the Chinese history with its own political language. This concept not only serves to legitimize the dominion of the Tianzi (Son of God Heaven) in China, but also makes possible a political internalization instead of the territorial expansion in the East Asian area. The "Heaven" (or Sky) is fundamental to understand the revolution of power in Ancient China, with the various meanings in which it has been interpreted. This is finally recognized as the supreme god, that the Tianzi inherited and obtained dominion over the corresponding earth. However, with the divine and ethical nature of Heaven, the dominator is required to have the virtue and good execution of power to keep the authorization in hand. With this text, the origin and the main development of the Tianxia system are revealed as the legitimizing regime of Chinese politics.
PLANO DE DESENVOLVIMENTO INSTITUCIONAL E O BALANCED SCORECARD: CASO DE UMA UNIVERSIDADE PÚBLICA FEDERAL
Authors: Nuintin Adriano Antonio , Curi Maria Aparecida , De Souza Paulo Roberto Rodrigues
Published: May 2023

O estudo tem como objetivo apresentar a elaboração do Plano de Desenvolvimento Institucional (PDI) de uma Universidade Federal de acordo com os preceitos do Balanced Scorecard. Para a consecução do objetivo proposto, com base na literatura, o estudo buscou realçar a importância do planejamento estratégico e o processo de implementação do Balanced Scorecard (BSC). O PDI é um instrumento de planejamento e de gestão da Universidade, o qual evidencia, além de outros elementos, à missão a que se propõe, seus valores e à sua visão de futuro, materializados nos objetivos estratégicos e suas respectivas metas. O PDI é construído a cada cinco anos, a metodologia para sua elaboração é definida pela Instituição, sendo muito importante a participação de toda a comunidade acadêmica. O presente trabalho é caracterizado como uma pesquisa descritiva, com abordagem predominantemente qualitativa dos dados, realizado por meio de um estudo de caso de uma Universidade Pública. O caso estudado optou pela utilização dos preceitos do BSC para a construção do PDI, sendo dividido em três etapas, (i) definição da missão, da visão e dos valores da Instituição; (ii) definição das perspectivas estratégicas; e (iii) definição dos objetivos estratégicos, dos indicadores e das metas. O mapa estratégico e o painel de medição de desempenho, resultantes desta metodologia, propiciam aos gestores o acompanhamento dos resultados realizados e dos resultados esperados, de forma a tomar decisões no sentindo de manter ou corrigir as ações que estão sendo executadas por parte de todos os envolvidos.
Análise dos Efeitos da Emancipação Legal Matrimonial e o Fim da Sociedade Conjugal pelo Divórcio
Authors: Haidar Gomes Raphael
Published: May 2023

Recebido: 05/07/2021

Aprovado: 22/03/2021

O presente estudo tem como desígnio primordial esclarecer o impacto da emancipação no cotidiano civilista do indivíduo, o qual foi anteriormente adquirido a partir do matrimônio, inclusive dirimir divergências e obscuridades acerca da permanência dos efeitos emancipatórios pós divórcio, já que a matéria em tela não possuí grande visibilidade nos estudos e na prática jurídica contemporânea. Utilizou-se para a construção deste estudo diversas doutrinas jurídicas clássicas e as respectivas linhas de raciocínio de seus autores, além do levantamento da linha jurisprudencial pátria dos tribunais brasileiros como entendimento da matéria ao mundo fático de modo a esclarecer e concretizar a destinação dos efeitos da emancipação com a ocorrência do fim da sociedade conjugal. Por fim, concluiu-se que apesar do término do matrimônio, os efeitos da emancipação não se extinguem, ocasionando na permanência da aquisição da maioridade para todos os atos da vida civil, ainda que o divórcio tenha ocorrido antes maioridade hereditária propriamente dita.
Endometrial cancer: Pathophysiology, diagnosis and management
Authors: Doke Rohit R , Lende Aditi R , Mule Shweta S , Mahajan Mrunal S , Kulawade Pranali , Korde Gayatri V , Bhand Rutuja B
Published: May 2023

The most prevalent gynecologic disease is cancer of the endometrium, In the US, it is the fourth most prevalent malignancy in women after breast, lung, and colorectal malignancies. Despite a steady prevalence of sickness, during the past 20 years, the death rate has climbed by more than 100%. The risk factors of endometrial cancer includes unopposed estrogen therapy, early menarche, late menopause, tamoxifen therapy, nulliparity, infertility or inability to ovulate, and polycystic ovarian syndrome. Ageing, obesity, hypertension, diabetes mellitus, and genetic nonpolyposis colorectal cancer are additional risk factors.

This article presents an overview of endometrial carcinoma's epidemiology, prevention, diagnosis, therapy, and prognosis. Chemotherapy, radiation, surgery, and radiation therapy are all forms of treatment. Nonsurgical treatments can be used to treat endometrial hyperplasia with a low to moderate risk. The likelihood of survival is often determined by the disease stage and histology, with the majority of patients at stages I and II having a good prognosis. Endometrial cancer may be prevented in part by managing risk factors such obesity, diabetes, and hypertension.
Revisiting novel interventions in melanoma
Authors: Chaudhry Sunil
Published: May 2023

Malignant tumor which that arises from uncontrolled proliferation of melanocytes is melanoma. Its rare tumor in India, compared to other tropical countries. Fair skin populations have higher incidences of melanoma. The relative mortality is reduced to nearly half with scrupulous use of sunscreens - SPF 50 blocks 98% of UVB rays. Melanomas are observed more in countries like Australia and New Zealand (due to actinic rays (UV B rays) of light) and thus guidelines from their ministry of health has been published.

First line drugs for melanoma unresectable stage III or IV metastatic disease include Pembrolizumab and Nivolumab. Studies have shown that Pembrolizumab improved overall survival (OS) compared with ipilimumab. Ipilimumab/Nivolumab combination was significantly better than ipilimumab monotherapy. Similarly nivolumab/ipilimumab combination therapy was better than compared with ipilimumab monotherapy regardless of BRAF mutation status. Vemurafenib and Dabrafenib (Tyrosine kinase inhibitors) were developed to inhibit BRAF with mutations at V600. Dabrafenib/Trametinib or Vemurafenib/Cobimetinib combinations were better than monotherapy.

Surgery remains the best option for cure in localized, invasive melanoma, with good overall survival rate.
Configuration and Strategic Scenarios in the Northwest Syria
Authors: Markelov Svyatoslav
Published: May 2023

Three years have passed since the massive military operation of Syrian Army. Nowadays territories of Syrian provinces Idlib and Aleppo which are partly under control of Syrian Army, partly under groups of islamists, and with a little presence of Kurdish forces, still are the most problematic point on the Syrian map, where interests of all main actors of Syrian conflict are crossed, where that conflict has become multi-layered, and where contradictions manifest themselves in artillery strikes and firefights despite the freezing of the hot phase of the conflict. In this article we will try to open up desires of parties of conflict and to show up scenarios, based on formed prerequisites, of the future of Northwest Syria for coming years.
Editorial - Edição Especial Administração
Authors: Carvalho João Francisco Sarno
Published: May 2023

Editorial - Edição Especial Administração
Diagnóstico de enfermagem sofrimento espiritual padronização e implementação na pratica clínica: revisão integrativa
Authors: Andrade João Vitor , Lins Ana Luiza Rodrigues
Published: May 2023

O presente artigo, objetiva avaliar a padronização do diagnostico sofrimento espiritual na pratica clínica. Trata-se de um estudo descritivo do tipo revisão integrativa de literatura, sendo a busca realizada de julho a agosto de 2018. Os descritores foram: Diagnóstico de Enfermagem; Espiritualidade; Angústia Espiritual. Amostra composta por nove artigos. Como resultados, percebeu-se que 66% das produções são dos últimos cinco anos, a maioria das publicações é em língua inglesa (66%). Evidenciou-se duas categorias de análise: padronização do diagnóstico e implementação do mesmo na pratica clínica. Percebeu-se que existe uma dificuldade na padronização do diagnostico sofrimento espiritual para sua implementação na pratica clínica, sobretudo em decorrência de sua subjetividade e despreparo dos profissionais. Abordar a dimensão psicoespiritual, principalmente em relação ao sofrimento espiritual é um processo complexo, sendo essencial a formulação de novos estudos na temática, bem como maior disseminação e formação dos futuros profissionais da saúde para essa abordagem.
APRENDIZAGEM DE MÁQUINA APLICADA À ANÁLISE DE BATIMENTOS CARDÍACOS
Authors: MEZAVILA Samuel A. , DIAS Nykollas A. A. , Franco Matheus Eloy
Published: May 2023

A inserção da Inteligência Artificial (IA) nas atividades do dia-a-dia é uma realidade. Além das práticas diárias comuns, o aprendizado de máquina aplicado na medicina é importante, sendo uma das principais áreas de estudo da IA.  Diagnósticos médicos podem ter apoio com a utilização de algoritmos inteligentes, tendo em vista a rapidez e eficiência que podem proporcionar. Este artigo apresenta um estudo sobre a implementação de um algoritmo de aprendizagem de máquina utilizando-se a linguagem Python para análises de eletrocardiogramas, classificando o risco do paciente de sofrer infarto do miocárdio.
SISTEMA SUPERVISÓRIO NO CONTROLE DE DEMANDA EM ESTUFAS BASEADO NA PLATAFORMA RADIUINO
Authors: De Castilho Talles Ribeiro , Ferroni Eduardo Henrique
Published: May 2023

As tecnologias da informação com a engenharia avançam exponencialmente na construção de ferramentas para várias áreas de conhecimento, inclusive na área de agricultura e plantio, com soluções significativas e desempenho produtivo satisfatório aos produtores, com o conceito da “Internet das Coisas” (IoT), como sistemas de irrigação, controle de temperatura e umidade do ar e solo em estufas. Com isso, foi desenvolvido um sistema supervisório para gerenciamento de consumo de energia elétrica e controle de demanda, baseando-se em um protótipo de Rede de Sensores Sem Fio (RSSF) na plataforma Radiuino, automatizando o cultivo protegido. Monitorando o consumo de energia elétrica, propiciando economia, controlando a demanda energética necessária para o ambiente, onde, a partir do sensoriamento, determinam-se os melhores momentos para acionamento e desligamento de cargas existentes. Ressalta-se que nesta prototipagem considera-se uma estufa que possui um sistema de irrigação, realizado por eletrobomba, para controle da umidade do solo, e um sistema de exaustão, para controle da temperatura, por meio de exaustor, com a finalidade de renovação do ar no interior do ambiente. O projeto realizado demonstrou uma performance satisfatória, com uma significativa melhora no processo de controle do ambiente, monitorando o cultivo em tempo real por dispositivos conectados a internet, mantendo os parâmetros vitais às plantas presentes na estufa, tratando a questão da eficiência energética junto aos produtores, mostrando a importância de se evitar desperdícios de energia, contribuindo assim também na entrega demandada de energia, pelas concessionárias.
Percepção e perspectivas sobre o Mercado Financeiro de universitários de uma universidade de Minas Gerais
Authors: Reis Davi Lemos
Published: May 2023

O objetivo deste presente estudo foi investigar a percepção sobre Mercado Financeiro de universitários dos cursos de Administração de Empresas e Ciências Contábeis em uma universidade de Minas Gerais. Para tanto, buscou-se investigar alunos que estivessem cursando ambos os cursos no momento da pesquisa por meio de um método básico, descritivo e exploratório, de abordagem quantitativa com coleta de dados no local de pesquisa por meio de questionário fechado de múltipla escolha. A partir da amostra não probabilística de alunos dos citados cursos, em uma população de 515, foi possível levantar dados para compreender a percepção e perspectiva dos alunos sobre o Mercado Financeiro. A maioria dos alunos, 58,3%, consideram que seus conhecimentos são ao menos razoável sobre o Mercado Financeiro e que seu perfil é propenso ao risco. Os itens principais levados em conta ao optar por investimento, são taxa de retorno e risco do investimento, com 48,8% e 28,6%, enquanto o investimento preferido foi a poupança, com 39,2% das respostas, enquanto esse também é considerado o mais seguro por 69% dos alunos. Também se verificou que 48,8% preferem investir por conta própria, e 88,7% acham melhor investimentos diversificados. Por fim ao final da graduação, 89,3% dos alunos pretendem realizar cursos específicos para aprofundamento dos conhecimentos.
Liposuction as a Stage of Abdominoplasty
Authors: Vinnik Yurii Semenovich , Pakhomova Regina Alexandrovna , Babadzhanian Akop Manasovich , Kochetova Lyudmila Viktorovna , Fedotov Ivan Andreevich , Sindeeva Lyudmila Victorovna
Published: May 2023

Introduction. Modern options of plastic surgery tend to improve clinical outcomes, introduce minimally invasive methods, increase the quality of the cosmetic effect, provide long-term preservation of the effect, and use the most efficient and safe procedures. In this paper, the authors reviewed the main options for performing liposuction as a stage of abdominoplasty. The aim of research was to study the clinical outcomes of abdominoplasties combined with liposuction performed in plastic clinics in Krasnoyarsk, and systematize their approaches.Materials and methods. This prospective and retrospective study involved 172 patients who underwent abdominoplasty with liposuction or liposuction in the Center for Plastic Surgery and Outpatient Healthcare and the Department of Plastic and Reconstructive Surgery of the Clinical Hospital "RZD-Medicine", Krasnoyarsk. The average age of women was 38 years.Results and discussions. The ways of combining liposuction and abdominoplasty are extremely diverse due to effect of liposuction on the clinical outcomes of abdominoplasty. The volume of liposuction, the terms of liposuction, the area and access of surgical intervention are the most important issues for providing an aesthetic result. According to our findings, 30 women (24%) were performed solely liposuction of the anterior abdominal wall, 10 (8%) women were performed mini-abdominoplasty combined with liposuction, 31 women underwent mini-abdominoplasty or abdominoplasty without liposuction (29%), abdominoplasty combined with liposuction was performed in 54 (42%), which was the largest proportion compared to other types of interventions. Systematization of liposuction options used in plastic clinics in Krasnoyarsk allows developing a scheme for the major, most commonly used approaches to combine these types of operations. Local complications are more common in women with BMI=30-40. In the postoperative period, local complications were observed in 5.8% of cases; systemic complications were not detected in this study.Conclusion. Effectiveness analysis of the results obtained demonstrated that the most effective way of the intervention is to perform liposuction during abdominoplasty. Liposuction as a stage of abdominoplasty with a competent and personalized approach improves the effectiveness of abdominoplasty and allows achieving an ideal aesthetic result.
Successful Treatment Of The Patient With Advanced Testic Cancer
Authors: Stepanova Yulia Aleksandrovna , Gritskevich Alexander Anatolyevich , Oganyan Vardan Arshavirovich , Kalinin Dmitry Valerievich
Published: May 2023

Testicular cancer is a rare oncourological disease. Of great significance is the fact of the disease onset precisely at the age when men are planning their future life: education, family, etc. According to current clinical guidelines, the treatment of this disease should be complex, including surgical treatment, polychemotherapy and external beam radiation therapy, which leads to a cure in 90% of cases.In the presented clinical case, a 25-year-old patient was diagnosed with right testicular cancer stage III, T2N3M1S0 [PUL]. However, despite the significant initial prevalence of the pathological process, as well as the detection of a single retroperitoneal metastasis in the pancreas two years after the last stage of surgical treatment, the applied multi-stage tactics of complex treatment of the patient allowed not only removing the tumor and metastases, but also rehabilitating the patient socially.
Two-Stage Abdominal Wall Reconstruction in a Patient with a Complex Postoperative Hernia
Authors: Gogia Badri Shotaevich , Chertova Anastasija Dmitrievna , Aljautdinov Rifat Rushanovich , Karmazanovsky Grigory Grigorievich
Published: May 2023

Surgical treatment of incisional hernia is an actual problem of abdominal surgery. Despite the improvement of surgical techniques, the results of surgical treatment cannot be considered satisfactory: the recurrence rate continues to be high and is due to failures in the reconstruction of complex ventral hernia. Although there are many works devoted to various aspects of the surgical treatment of patients with complex incisional hernias, the problem is not sufficiently resolved. The treatment of this category of patients is a difficult task for both surgeons and patients due to the high risk of general and local complications. A clinical case of surgical treatment of a patient with a complex incisional hernia is presented, in which it was possible to carry out a complete reconstruction of the anterior abdominal wall in two stages without "components separation" method.
Alternative Options of Blood Vessels Anastomosis
Authors: Makaev Aleksandr Gennadievich , Zhulkov Maxim Olegovich , Sirota Dmitry Andreevich , Agaeva Khava Abdullayevna , Grenaderov Alexander Sergeevich , Makaev Andrey Gennadievich , Sabetov Azat Kerimbekovich , Khvan Dmitry Sergeevich
Published: May 2023

For a number of centuries, the problem of bleeding arrest from damaged vessels remains the major issue of surgery (alongside with infectious complications and fight against the pain syndrome). The development of vascular surgery began exactly when bleeding from a damaged vessel was arrested by tying it, and the introduction of reconstructive vascular surgery, being one of the most outstanding achievements of the 20th century, was the peak of creation. With the advent and development of this relatively young branch of clinical surgery, it became possible to effectively help patients with various vascular pathologies, previously considered incurable and doomed to death. However, the development of each industry is necessarily associated with the development of technical support. The lack of high-quality suture material and instruments has restrained the development of reconstructive vascular surgery for a long time; this fact forced researchers and surgeons to develop techniques for the seamless connection of blood vessels. Despite the widespread use of manual surgical suture, it is not always possible to use this option due to altered vascular walls. Development of technology for manufacturing synthetic materials allowed for techniques providing fast and high-quality connection of blood vessels, significantly reducing the time required for reconstruction and, as a result, reducing the incidence of complications.
Israil PERELMAN: the shore of his life, or the distance of youth lived (to the 130th of birthday)
Authors: Larichev Andrey Borisovich
Published: May 2023

For Professor Israil Moiseevich Perelman (1892-1954) the events of the second half of 1951 unfolded tragically. The release from the head of the department of general surgery and the appointment to the post of head of the department of topographic anatomy with operative surgery of the Yaroslavl Medical Institute deprived him of the opportunity to practice practical surgery. Such objections were not accepted, and I.M. Perelman was fired from the institute as not starting work. In the spring of 1952, the disgraced professor returned to Belarus. Having visited Minsk and found himself on the banks of the post-war Svisloch, he poignantly felt the atmosphere of Lyakhovka half a century ago. Memory brought him back to the summer of 1905, when he became a student of the Minsk real school a storehouse of knowledge for those who, following the results of their studies, were willingly enrolled in metropolitan universities. Talented teachers took an active part in shaping the personality of Israil Perelman, including Samoilo I.I., Gurvich O.Ya., Pionier L.O., Skokanek A.I. The period of adolescence was also enriched by the first charm of the soul, when Israil experienced sympathy for the one who became the secret of ardent feelings. Their reciprocity turned out to be fragile, short-lived and irretrievably gone into the distant past. In a real school, fate brought the young man to O.L. Lunts, who served here as a staff doctor. As an experienced clinician and an outstanding public figure, the doctor shared his life experience. His stories strengthened the desire to engage in healing and instilled faith in the correctness of the choice of the future profession. The logical result of seven years of study in a real school was the receipt of a certificate of complete secondary education, bringing Israil Perelman one step closer to achieving his main dream to be a doctor.
Prevention of Gastrointestinal Bleeding in Patients Operated on Coronary Arteries for Acute Coronary Syndrome
Authors: Polyantsev Alexander Alexandrovich , Frolov Denis Vladimirovich , Linchenko Alexander Mikhailovich , Karpenko Svetlana Nikolaevna , Kosivtsov Oleg Aleksandrovich , Ievlev Vladimir Andreevich , Panshin Nikolay Gennadievich , Chernovolenko Andrey Andreevich , Kaplunova Evgeniya Vadimovna
Published: May 2023

Introduction. Acute coronary syndrome is a collective concept that reflects any form of exacerbation of coronary heart disease from unstable angina to acute myocardial infarction. Modern principles for the diagnosis and treatment of this syndrome are coronary angiography and urgent stenting of the affected coronary artery. These patients, having survived a life-threatening condition and surgical treatment, have a high probability of acute erosive and ulcerative gastroduodenal lesions and dependent gastrointestinal lesions. As a result, conservative treatment of acute ulcers and erosions complicated by bleeding remains unsatisfactory, mortality ranges from 36.4 to 50-80%.The aim of the study was to evaluate effectiveness of the proposed measures to prevent erosive and ulcerative lesions of the stomach and duodenum and gastrointestinal bleeding in patients with acute coronary syndrome who underwent coronary artery stenting.Materials and methods. The study included 614 patients who underwent percutaneous coronary intervention and stenting of the arteries of the heart due to the development of acute coronary syndrome. The patients were divided into two groups. The first group included 284 patients treated in 2018. Prevention of acute erosive and ulcerative gastroduodenal lesions was not routinely performed in this group. The second group included 330 patients treated in 2019. All patients in this group underwent prophylaxis and included omeprozole 40 mg per day from the first hours of the patient's stay in the hospital.Results. During the entire study period, 31 patients died in the early and late postoperative period in the first group, 18 of them during the first hospitalization. In the second group, 35 patients died during the entire study period in the early and late postoperative period, 21 of them during the first hospitalization. With the development of gastrointestinal bleeding, the probability of a full recovery in a patient with acute coronary syndrome is extremely low, and the system of preventive measures avoids this problem.Conclusion. Prevention of stressful acute erosive and ulcerative gastroduodenal lesions due to use of intravenous proton pump inhibitors in increased dosages (omeprozole 40 mg per day) is indicated to the patients of the studied group; in the presence of additional risk factors, the prophylactic dosage of proton pump inhibitors is doubled (omeprozole 40 mg 2 times a day). Mandatory non-invasive diagnosis of Helicobacter pylori for all patients is also indicated; if the condition is detected, eradication therapy is to be carried out. It is also required to apply proton pump inhibitors for the entire period of dual antiplatelet or anticoagulant therapy.
Direct Endolymphatic Ozone Therapy in Patients with Diabetic Foot Syndrome: Analysis of the Effectiveness
Authors: Zolotukhin Oleg Vladimirovich , Аralova Maria Valerievna , Glukhov Alexander Anatolyevich , Аlimkina Yuliya Nikolaevna
Published: May 2023

Introduction. Chronic inflammatory process on the foot leads to the depletion of immune defense mechanisms against infection in patients with diabetes mellitus. Application of ozonized solutions, endolymphatic therapy contributes to fight against the infectious process and maintenance of the body homeostasis.The aim of the study was to evaluate safety and clinical effectiveness of direct endolymphatic ozone therapy in patients with purulent-necrotic complications of diabetic foot syndrome.Methods. Clinical outcomes of direct endolymphatic ozone therapy, being part of complex therapy, were analyzed in 23 patients with purulent-necrotic complications of diabetic foot syndrome. Inclusion criteria were the degree of damage to the foot according to Wagner 2-4, ankle-brachial index (ABI) less than 0.7. Direct antegrade endolymphatic ozone therapy consisted of introduction of ozonized isotonic sterile sodium chloride solution into the lymphatic collector of the middle third leg for 5 days. The parameters of treatment duration, degree of the pain syndrome, severity of surgical intervention, dynamics of the bacterial contamination, leukocytes and blood lymphocytes, leukocyte indices were assessed.Results. Under endolymphatic ozone therapy, all patients reported positive changes in subjective perception, the level of peripheral blood lymphocytes increased by 15.3%, which reflected an improvement in the adaptive potential of the body, bacterial contamination decreased by 68.6%, the severity of operations decreased by 39.4%. The duration of treatment did not change statistically significant. Conclusion. Direct endolymphatic ozone therapy is an effective way to influence the course of the purulent-necrotic process in the complex treatment of diabetic syndrome. The main focus of the technique is correction of the bacterial contamination of inflammation; this option promotes activation of reparative processes in the wound, reduces the risk of infection generalization, and preserves a limb footing ability. The use of leukocyte indices to assess the course of the inflammatory process on the foot in patients with diabetes mellitus is difficult in clinical practice due to the decreased body's reactivity.