bluuebunny/crossref_metadata_2025 huggingface dataset:
Electrophysiological Mechanisms Underlying T-Wave Alternans and Their Role in Arrhythmogenesis
Authors: You Tingting , Luo Cunjin , Zhang Kevin , Zhang Henggui
Published: March 2021

T-wave alternans (TWA) reflects every-other-beat alterations in the morphology of the electrocardiogram ST segment or T wave in the setting of a constant heart rate, hence, in the absence of heart rate variability. It is believed to be associated with the dispersion of repolarization and has been used as a non-invasive marker for predicting the risk of malignant cardiac arrhythmias and sudden cardiac death as numerous studies have shown. This review aims to provide up-to-date review on both experimental and simulation studies in elucidating possible mechanisms underlying the genesis of TWA at the cellular level, as well as the genesis of spatially concordant/discordant alternans at the tissue level, and their transition to cardiac arrhythmia. Recent progress and future perspectives in antiarrhythmic therapies associated with TWA are also discussed.
Neural Responses of Benefiting From the Prosocial Exchange: The Effect of Helping Behavior
Authors: Olivo Daniele , Di Ciano Andrea , Mauro Jessica , Giudetti Lucia , Pampallona Alan , Kubera Katharina M. , Hirjak Dusan , Wolf Robert Christian , Sambataro Fabio
Published: March 2021

Prosocial behavior is critical for the natural development of an individual as well as for promoting social relationships. Although this complex behavior results from gratuitous acts occurring between an agent and a recipient and a wealth of literature on prosocial behavior has investigated these actions, little is known about the effects on the recipient and the neurobiology underlying them. In this study, we used functional magnetic resonance imaging to identify neural correlates of receiving prosocial behavior in the context of real-world experiences, with different types of action provided by the agent, including practical help and effort appreciation. Practical help was associated with increased activation in a network of regions spanning across bilateral superior temporal sulcus, temporoparietal junction, temporal pole, and medial prefrontal cortex. Effort appreciation was associated with activation and increased task-modulated connectivity of the occipital cortex. Prosocial-dependent brain responses were associated with positive affect. Our results support the role of the theory of mind network and the visual cortices in mediating the positive effects of receiving gratuitous help. Moreover, they indicate that specific types of prosocial behavior are mediated by distinct brain networks, which further demonstrates the uniqueness of the psychological processes underlying prosocial actions.
“Red-Green” or “Brown-Green” Dichromats? The Accuracy of Dichromat Basic Color Terms Metacognition Supports Denomination Change
Authors: Moreira Humberto , Lillo Julio , Álvaro Leticia
Published: March 2021

Two experiments compared “Red-Green” (R-G) dichromats’ empirical and metacognized capacities to discriminate basic color categories (BCCs) and to use the corresponding basic color terms (BCTs). A first experiment used a 102-related-colors set for a pointing task to identify all the stimuli that could be named with each BCT by each R-G dichromat type (8 protanopes and 9 deuteranopes). In a second experiment, a group of R-G dichromats (15 protanopes and 16 deuteranopes) estimated their difficulty discriminating BCCs-BCTs in a verbal task. The strong coincidences between the results derived from the pointing and the verbal tasks indicated that R-G dichromats have very accurate metacognition about their capacities (they only had considerable difficulty discriminating 13 out of the total of 55 possible BCT pairs) and limitations (Brown-Green and Blue-Purple pairs were rated especially difficult to differentiate) in the use of BCTs. Multidimensional scaling (MDS) solutions derived from both tasks were very similar: BCTs in R-G dichromats were properly represented in 2D MDS solutions that clearly show one chromatic dimension and one achromatic dimension. Important concordances were found between protanopes and deuteranopes. None of these dichromats showed substantial difficulty discriminating the Red-Green pair. So, to name them “R-G” dichromats is misleading considering their empirical capacities and their metacognition. Further reasons to propose the use of the alternative denomination “Brown-Green” dichromats are also discussed. We found some relevant differences between the “Brown-Green” dichromats’ empirical and self-reported difficulties using BCTs. Their metacognition can be considered a “caricature” of their practical difficulties. This caricature omits some difficulties including their problems differentiating “white” and “black” from other BCTs, while they overestimate their limitations in differentiating the most difficult pairs (Brown-Green and Blue-Purple). Individual differences scaling (INDSCAL) analyses indicated that the metacognition regarding the use of BCTs in “Brown-Green” dichromats, especially deuteranopes, is driven slightly more by the chromatic dimension and driven slightly less by the achromatic dimension, than their practical use of BCTs. We discuss the relevance of our results in the framework of the debate between the linguistic relativity hypothesis (LRH) and the universal evolution (UE) theories.
Descriptive Study of Transgender Youth Receiving Health Care in the Gender Identity Program in Southern Brazil
Authors: Soll Bianca Machado Borba , Fontanari Anna Martha , Brandelli Costa Angelo , Chinazzo Ítala , Silva Dhiordan Cardoso , Guadagnin Fernanda , Tramontina Silzá , Lobato Maria Inês Rodrigues
Published: March 2021

Since 2014, the Gender Identity Program (PROTIG) of Hospital de Clínicas de Porto Alegre (HCPA) has been assisting transgender youth seeking gender-affirmative treatment offered at a public health-care service specializing in gender in southern Brazil. This article aims to analyze sociodemographic and clinical data regarding the diagnoses of gender dysphoria and gender incongruence, psychiatric comorbidities, and clinical aspects of a sample of transgender youths seeking health care in the gender identity program. The research protocol consisted of a survey of the data collected in the global psychological evaluation performed at the health-care service for youths diagnosed with gender incongruence and their caretakers. Participating in this research were 24 transgender youths between 8 and 16 years old with diagnostic overlap of gender dysphoria [Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5)] and gender incongruence [International Classification of Diseases, 11th Revision (ICD-11)] and 34 of their caregivers. Of the young people, 45.8% were positive for some psychiatric comorbidity throughout their lives, with almost half (45.4%) having two or more psychiatric comorbidities in addition to gender dysphoria. The mental health professionals comprising affirmation care teams face the challenge of adapting the care protocols to the uniqueness of each demand by developing individualized forms to promote healthy development. This can be done by focusing not only on medical and physical interventions for gender affirmation but also on the promotion of mental health and general emotional well-being. Thus, the gender affirmation model, which advocates for global assessment and personalized guidance, proved to be adequate. Nevertheless, access to multidisciplinary health services specializing in gender is essential for promoting the general well-being of the population of transgender youth.
Third Follow-Up of the Study on Occupational Allergy Risks (SOLAR III) in Germany: Design, Methods, and Initial Data Analysis
Authors: Forster Felix , Kreißl Sylvia , Wengenroth Laura , Vogelberg Christian , von Mutius Erika , Schaub Bianca , Nowak Dennis , Weinmann Tobias , Radon Katja , Gerlich Jessica
Published: March 2021

Introduction:Asthma and allergies are complex diseases affected by genetic and environmental factors, such as occupational and psychosocial factors, as well as interactions between them. Although childhood is a critical phase in the development of asthma and allergies, few cohort studies on occupational outcomes followed up participants from childhood onwards. We present design, methods, and initial data analysis for the third follow-up of SOLAR (Study on Occupational Allergy Risks), a prospective and population-based German asthma and allergy cohort.

Methods:The SOLAR cohort was initially recruited in 1995–1996 for Phase II of the German branch of the International Study of Asthma and Allergies in Childhood (ISAAC II) and followed up three times since, in 2002–2003, 2007–2009, and 2017–2018. During the third follow-up (SOLAR III), participants were between 29 and 34 years old. Since SOLAR focuses on occupational exposures, follow-ups were conducted at important points in time of the development of participants' career. To evaluate the potential of selection bias, responders and non-responders were compared based on variables from earlier study phases. In responders, frequency and pattern of missing values were examined and compared within the subsets of paper and online versions of the used questionnaires.

Results:In total, 1,359 participants completed the questionnaire of the third follow-up (47.3% of eligible participants). Initially, the cohort started with 6,399 participants from the ISAAC II questionnaire study. A selection process led to a study population that is more female, higher educated, smokes less and has a higher proportion of certain asthma and allergy symptoms (also in their parents) than the initial cohort. Pattern and frequency of missing values were different for paper and online questionnaires.

Discussion:The third follow-up of the SOLAR cohort offers the opportunity to analyze the course of asthma and allergies and their associations to environmental, occupational and psychosocial risk factors over more than 20 years from childhood to adulthood. Selection processes within the cohort might lead to bias that needs to be considered in future analyses.
Protection Against Solar Ultraviolet Radiation in Outdoor Construction Workers: Study Protocol for a Non-randomized Controlled Intervention Study
Authors: Keurentjes Anne J. , Kezic Sanja , Rustemeyer Thomas , Hulshof Carel T. J. , van der Molen Henk F.
Published: March 2021

Introduction: Non-melanoma skin cancer (NMSC) incidence is increasing, and occupational solar exposure contributes greatly to the overall lifetime ultraviolet radiation (UVR) dose. This is reflected in an excess risk of NMSC showing up to three-fold increase in outdoor workers. Risk of NMSC can be reduced if appropriate measures to reduce UVR-exposure are taken. Regular use of sunscreens showed reduced risk of NMSC. However, sun-safety behavior in outdoor workers is poor. The objective of this study is to investigate the effectiveness of an intervention aiming at increasing sunscreen use by construction workers.

Methods: This non-randomized controlled intervention study is comprised of two intervention and two control groups recruited at four different construction sites in the Netherlands. The study population comprises ~200 construction workers, aged 18 years or older, followed during 12 weeks. The intervention consists of providing dispensers with sunscreens (SPF 50+) at construction sites and regular feedback on the application achieved by continuous electronic monitoring. All groups will receive basic information on UV-exposure and skin protection. Stratum corneum (SC) samples will be collected for measurement of biomarkers to assess internal UV-dose. External UV-dose will be assessed by personal UV-sensors worn by the workers during work-shifts in both groups. To detect presence of actinic keratosis (AK) or NMSC, a skin check of body parts exposed to the sun will be performed at the end of the study. The effect of the intervention will be assessed from data on self-reported sunscreen use by means of questionnaires collected on baseline and after 12 weeks of intervention (primary outcome). Levels of SC biomarkers of internal UV-dose, external UV-dose, number of sunburn episodes, and prevalence of NMSC including AK will be assessed as secondary outcomes. The electronically monitored sunscreen consumption will be assessed as process outcome.

Discussion: This study is intended to provide evidence of the effectiveness of a technology-driven intervention to increase sunscreen use in outdoor construction workers. Furthermore, it will increase insight in the UV-protective behavior, external and internal UV-exposure, and the prevalence of NMSC, including AK, in construction workers.

Trial Registration: The Netherlands Trial Register (NTR): NL8462 Registered on March 19, 2020.
Assessment of a Spatiotemporal Deep Learning Approach for Soil Moisture Prediction and Filling the Gaps in Between Soil Moisture Observations
Authors: ElSaadani Mohamed , Habib Emad , Abdelhameed Ahmed M. , Bayoumi Magdy
Published: March 2021

Soil moisture (SM) plays a significant role in determining the probability of flooding in a given area. Currently, SM is most commonly modeled using physically-based numerical hydrologic models. Modeling the natural processes that take place in the soil is difficult and requires assumptions. Besides, hydrologic model runtime is highly impacted by the extent and resolution of the study domain. In this study, we propose a data-driven modeling approach using Deep Learning (DL) models. There are different types of DL algorithms that serve different purposes. For example, the Convolutional Neural Network (CNN) algorithm is well suited for capturing and learning spatial patterns, while the Long Short-Term Memory (LSTM) algorithm is designed to utilize time-series information and to learn from past observations. A DL algorithm that combines the capabilities of CNN and LSTM called ConvLSTM was recently developed. In this study, we investigate the applicability of the ConvLSTM algorithm in predicting SM in a study area located in south Louisiana in the United States. This study reveals that ConvLSTM significantly outperformed CNN in predicting SM. We tested the performance of ConvLSTM based models by using a combination of different sets of predictors and different LSTM sequence lengths. The study results show that ConvLSTM models can predict SM with a mean areal Root Mean Squared Error (RMSE) of 2.5% and mean areal correlation coefficients of 0.9 for our study area. ConvLSTM models can also provide predictions between discrete SM observations, making them potentially useful for applications such as filling observational gaps between satellite overpasses.
By-Product Feeds: Current Understanding and Future Perspectives
Authors: Yang Kaili , Qing Yiqing , Yu Qifang , Tang Xiaopeng , Chen Gang , Fang Rejun , Liu Hu
Published: March 2021

Recently, industrial and agricultural by-products, resulting from crops, fruit and vegetable processing which can be used in animal diets have become a hot topic in the animal feed industry. This review focuses on the agro-industry by-products as feeds, not only for the nutritional values, but also for their nutricine contribution. In this review, we described the chemical composition of some by-products as feeds and their limiting factors in animal feeding.
Nitrosative Redox Homeostasis and Antioxidant Response Defense in Disused Vastus lateralis Muscle in Long-Term Bedrest (Toulouse Cocktail Study)
Authors: Blottner Dieter , Capitanio Daniele , Trautmann Gabor , Furlan Sandra , Gambara Guido , Moriggi Manuela , Block Katharina , Barbacini Pietro , Torretta Enrica , Py Guillaume , Chopard Angèle , Vida Imre , Volpe Pompeo , Gelfi Cecilia , Salanova Michele
Published: March 2021

Increased oxidative stress by reactive oxygen species (ROS) and reactive nitrogen species (RNS) is a major determinant of disuse-induced muscle atrophy. Muscle biopsies (thigh vastus lateralis, VL) obtained from healthy male subjects enrolled in the Toulouse Cocktail bedrest (BR) study were used to assess efficacy of an antioxidant cocktail (polyphenols, omega-3, vitamin E, and selenium) to counteract the increased redox homeostasis and enhance the antioxidant defense response by using label-free LC–MS/MS and NITRO-DIGE (nitrosated proteins), qPCR, and laser confocal microscopy. Label-free LC–MS/MS indicated that treatment prevented the redox homeostasis dysregulation and promoted structural remodeling (TPM3, MYH7, MYBPC, MYH1, MYL1, HRC, and LUM), increment of RyR1, myogenesis (CSRP3), and skeletal muscle development (MUSTN1, LMNA, AHNAK). These changes were absent in the Placebo group. Glycolysis, tricarboxylic acid cycle (TCA), oxidative phosphorylation, fatty acid beta-oxidation, and mitochondrial transmembrane transport were normalized in treated subjects. Proteins involved in protein folding were also normalized, whereas protein entailed in ion homeostasis decreased. NITRO-DIGE analysis showed significant protein nitrosylation changes for CAT, CA3, SDHA, and VDAC2 in Treatment vs. Placebo. Similarly, the nuclear factor erythroid 2-related factor 2 (Nrf-2) antioxidant response element (Nrf-2 ARE) signaling pathway showed an enhanced response in the Treatment group. Increased nitrosative redox homeostasis and decreased antioxidant defense response were found in post-BR control (Placebo, n = 10) vs. the antioxidant cocktail treated group (Treatment, n = 10). Taken together, increased nitrosative redox homeostasis and muscle deterioration during BR-driven physical inactivity were prevented, whereas decreased antioxidant nitrosative stress defense response was attenuated by Treatment suggesting positive effects of the nutritional intervention protocol in bedrest.
Characterization of Superplastic Deformation Behavior for a Novel Al-Mg-Fe-Ni-Zr-Sc Alloy: Arrhenius-Based Modeling and Artificial Neural Network Approach
Authors: Mosleh Ahmed O. , Kotov Anton D. , Kishchik Anna A. , Rofman Oleg V. , Mikhaylovskaya Anastasia V.
Published: March 2021

The application of superplastic forming for complex components manufacturing is attractive for automotive and aircraft industries and has been of great interest in recent years. The current analytical modeling theories are far from perfect in this area, and the results deduced from it characterize the forming conditions insufficiently well; therefore, successful numerical modeling is essential. In this study, the superplastic behavior of the novel Al-Mg-Fe-Ni-Zr-Sc alloy with high-strain-rate superplasticity was modeled. An Arrhenius-type constitutive hyperbolic-sine equation model (ACE) and an artificial neural network (ANN) were developed. A comparative study between the constructed models was performed based on statistical errors. A cross validation approach was utilized to evaluate the predictability of the developed models. The results revealed that the ACE and ANN models demonstrated strong workability in predicting the investigated alloy’s flow stress, whereas the ACE approach exhibited better predictability than the ANN.
Hybrid CMP Slurry Supply System Using Ionization and Atomization
Authors: Jo Hoseong , Lee Da Sol , Jeong Seon Ho , Lee Hyun Seop , Jeong Hae Do
Published: March 2021

Chemical mechanical planarization (CMP) is frequently used in semiconductor manufacturing to polish the surfaces of multiple layers in a wafer. The CMP uses a slurry that aids in fabricating a smooth surface by removing the excess materials. However, excessive use of slurry affects the environment and is expensive. Therefore, we propose a hybrid slurry supply system that combines ionization and atomization to reduce slurry consumption and improve the polishing quality. The proposed hybrid system atomizes the ionized slurry using electrolysis and a spray slurry nozzle. We compared the material removal rate (MRR) and polishing uniformity based on the slurry supply systems used in Cu and SiO2 non-patterned wafers. Additionally, the step height reduction and dishing were compared in the Cu-patterned wafers. The experimental analysis using the hybrid system confirmed a 23% and 25% improvement in the MRR and uniformity, respectively, in comparison with the conventional slurry supply system. This improvement can be attributed to the chemical activation and uniform supply of the ionized and atomized slurries, respectively. Moreover, a significant reduction was observed in dishing and pitch-size dependence. Furthermore, the proposed system prevents heat accumulation between the CMP processes, serving as a cooling system.
The Root Microbiome of Salicornia ramosissima as a Seedbank for Plant-Growth Promoting Halotolerant Bacteria
Authors: Ferreira Maria J. , Cunha Angela , Figueiredo Sandro , Faustino Pedro , Patinha Carla , Silva Helena , Sierra-Garcia Isabel N.
Published: March 2021

Root−associated microbial communities play important roles in the process of adaptation of plant hosts to environment stressors, and in this perspective, the microbiome of halophytes represents a valuable model for understanding the contribution of microorganisms to plant tolerance to salt. Although considered as the most promising halophyte candidate to crop cultivation, Salicornia ramosissima is one of the least-studied species in terms of microbiome composition and the effect of sediment properties on the diversity of plant-growth promoting bacteria associated with the roots. In this work, we aimed at isolating and characterizing halotolerant bacteria associated with the rhizosphere and root tissues of S. ramosissima, envisaging their application in saline agriculture. Endophytic and rhizosphere bacteria were isolated from wild and crop cultivated plants, growing in different estuarine conditions. Isolates were identified based on 16S rRNA sequences and screened for plant-growth promotion traits. The subsets of isolates from different sampling sites were very different in terms of composition but consistent in terms of the plant-growth promoting traits represented. Bacillus was the most represented genus and expressed the wider range of extracellular enzymatic activities. Halotolerant strains of Salinicola, Pseudomonas, Oceanobacillus, Halomonas, Providencia, Bacillus, Psychrobacter and Brevibacterium also exhibited several plant-growth promotion traits (e.g., 3-indole acetic acid (IAA), 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase, siderophores, phosphate solubilization). Considering the taxonomic diversity and the plant-growth promotion potential of the isolates, the collection represents a valuable resource that can be used to optimize the crop cultivation of Salicornia under different environmental conditions and for the attenuation of salt stress in non-halophytes, considering the global threat of arable soil salinization.
Detecting Crop Circles in Google Earth Images with Mask R-CNN and YOLOv3
Authors: Mekhalfi Mohamed Lamine , Nicolò Carlo , Bazi Yakoub , Al Rahhal Mohamad Mahmoud , Al Maghayreh Eslam
Published: March 2021

Automatic detection and counting of crop circles in the desert can be of great use for large-scale farming as it enables easy and timely management of the farming land. However, so far, the literature remains short of relevant contributions in this regard. This letter frames the crop circles detection problem within a deep learning framework. In particular, accounting for their outstanding performance in object detection, we investigate the use of Mask R-CNN (Region Based Convolutional Neural Networks) as well as YOLOv3 (You Only Look Once) models for crop circle detection in the desert. In order to quantify the performance, we build a crop circles dataset from images extracted via Google Earth over a desert area in the East Oweinat in the South-Western Desert of Egypt. The dataset totals 2511 crop circle samples. With a small training set and a relatively large test set, plausible detection rates were obtained, scoring a precision of 1 and a recall of about 0.82 for Mask R-CNN and a precision of 0.88 and a recall of 0.94 regarding YOLOv3.
Hydrothermal Carbonization of Lemon Peel Waste: Preliminary Results on the Effects of Temperature during Process Water Recirculation
Authors: Picone Antonio , Volpe Maurizio , Giustra Maria , Di Bella Gaetano , Messineo Antonio
Published: March 2021

Hydrothermal carbonization (HTC) is a promising thermochemical pre-treatment to convert waste biomass into solid biofuels. However, the process yields large amounts of organic process water (PW), which must be properly disposed of or reused. In this study, the PW produced from the hydrothermal carbonization of lemon peel waste (LP) was recycled into HTC process of LP with the aim of maximize energy recovery from the aqueous phase while saving water resources and mitigating the overall environmental impact of the process. The effects of HTC temperature on the properties of solid and liquid products were investigated during PW recirculation. Experiments were carried out at three different operating temperatures (180, 220, 250 °C), fixed residence times of 60 min, and solid to liquid load of 20 wt%, on a dry basis. Hydrochars were characterized in terms of proximate analysis and higher heating values while liquid phases were analyzed in terms of pH and total organic carbon content (TOC). PW recirculation led to a solid mass yield increase and the effect was more pronounced at lower HTC temperature. The increase of solid mass yield, after recirculation steps (maximum increase of about 6% at 180 °C), also led to a significant energy yield enhancement. Results showed that PW recirculation is a viable strategy for a reduction of water consumption and further carbon recovery; moreover preliminary results encourage for an in-depth analysis of the effects of the PW recirculation for different biomasses and at various operating conditions.
Why Should DNA Topoisomerase I Have a Scaffold Activity?
Authors: Di Felice Francesca , Camilloni Giorgio
Published: March 2021

Since the early 1990s, in vitro studies have demonstrated that DNA topoisomerase I promotes RNA polymerase II transcription, acting as a cofactor, regardless of its catalytic activity. Recent studies, carried in vivo, using yeast as a model system, also demonstrate that DNA topoisomerase I is able to recruit, without the involvement of its catalytic activity, the Sir2p deacetylase on ribosomal genes thus contributes to achieve their silencing. In this review, the DNA topoisomerase I capability, acting as a scaffold protein, as well as its involvement and role in several macromolecular complexes, will be discussed, in light of several observations reported in the literature, pointing out how its role goes far beyond its well-known ability to relax DNA.
Phytochemical Analysis and Biological Activities of the Ethanolic Extract of Daphne sericea Vahl Flowering Aerial Parts Collected in Central Italy
Authors: Frezza Claudio , Venditti Alessandro , De Vita Daniela , Sciubba Fabio , Tomai Pierpaolo , Franceschin Marco , Di Cecco Mirella , Ciaschetti Giampiero , Di Sotto Antonella , Stringaro Annarita , Colone Marisa , Gentili Alessandra , Serafini Mauro , Bianco Armandodoriano
Published: March 2021

In this paper, the first phytochemical analysis of the ethanolic extract of Daphne sericea Vahl flowering aerial parts collected in Italy and its biological activities were reported. Eleven compounds were identified i.e., α-linolenic acid (1), tri-linoleoyl-sn-glycerol (2), pheophorbide a ethyl ester (3), pilloin (4), sinensetin (5), yuanhuanin (6), rutamontine (7), syringin (8), p-coumaric acid (9), p-anisic acid (10) and caffeic acid (11). To the best of our knowledge, compounds (1-4, 7-8 and 10) were isolated from D. sericea for the first time during this work, whereas sinensetin (5) represents a newly identified component of the entire Thymelaeaceae family. The extract was found to possess radical scavenging against both DPPH• and 2,2′-azino-bis(3-thylbenzothiazoline-6-sulfonic acid (ABTS•+) radicals, with at least a 40-fold higher potency against the latter. Moreover, chelating abilities against both ferrous and ferric ions have been highlighted, thus suggesting a possible indirect antioxidant power of the extract. Although the precise bioactive compounds remain to be discovered, the polyphenolic constituents, including phenolic acids, tannins and flavonoids, seem to contribute to the antioxidant power of the phytocomplex. In addition, the extract produced cytotoxic effects in MDA-MB-231 and U87-MG cancer cell lines, especially at the concentration of 625 μg/mL and after 48–72 h. Further studies are required to clarify the contribution of the identified compounds in the bioactivities of the extract and to support possible future applications.
Rehabilitation of Falls in Parkinson’s Disease: Self-Perception vs. Objective Measures of Fall Risk
Authors: Sangarapillai Kishoree , Norman Benjamin M. , Almeida Quincy J.
Published: March 2021

Falls are an important cause of injury and increased hospital/long-term care facility stays and has been reported in 70% of people with Parkinson’s disease (PD), yet there is limited effectiveness of medications for reducing falls. As an adjunct, many exercise therapies succeed in objectively reducing the number of falls, but this may not translate to improved quality of life (QOL). Importantly, self-perceived fall risk has a greater influence on activities of daily living and QOL, making it important to evaluate in the rehabilitation of PD. The purpose of this study was to examine the influence of a 10-week exercise intervention (PD SAFE × TM) on self-perceived (according to balance confidence measures) and objective measures of gait that are commonly linked to fall risk in PD. Participants (N = 44) with PD completed PD SAFE × TM. Pre-/post-assessment involved the Activities-specific Balance Confidence Scale (perception), objective falls characteristics (stride time, stride width, stride length, and stride variability), and symptom severity (Unified Parkinson’s Disease Rating Scale motor subsection III (UPDRS-III)) after participants were stratified into a mild (no-balance impairment) vs. severe (balance impairment) groups. Overall disease severity (F (1, 43) = 8.75, p < 0.003) and all objective fall parameters improved (p < 0.05) in both groups, yet self-perceived fall risk improved in only the severe PD group F (1, 43) = 9.86, p < 0.022. Given that self-perceived fall risk and objective fall risk both play a role in the quality of life, identifying strategies to improve both aspects may be important in improving the overall quality of life.
Reality Capture of Buildings Using 3D Laser Scanners
Authors: Almukhtar Avar , Saeed Zaid O. , Abanda Henry , Tah Joseph H. M.
Published: March 2021

The urgent need to improve performance in the construction industry has led to the adoption of many innovative technologies. 3D laser scanners are amongst the leading technologies being used to capture and process assets or construction project data for use in various applications. Due to its nascent nature, many questions are still unanswered about 3D laser scanning, which in turn contribute to the slow adaptation of the technology. Some of these include the role of 3D laser scanners in capturing and processing raw construction project data. How accurate are the 3D laser scanner or point cloud data? How does laser scanning fit with other wider emerging technologies such as building information modeling (BIM)? This study adopts a proof-of-concept approach, which in addition to answering the aforementioned questions, illustrates the application of the technology in practice. The study finds that the quality of the data, commonly referred to as point cloud data, is still a major issue as it depends on the distance between the target object and 3D laser scanner’s station. Additionally, the quality of the data is still very dependent on data file sizes and the computational power of the processing machine. Lastly, the connection between laser scanning and BIM approaches is still weak as what can be done with a point cloud data model in a BIM environment is still very limited. The aforementioned findings reinforce existing views on the use of 3D laser scanners in capturing and processing construction project data.
Experience-Based Physico-Chemical Models for Long-Term Reinforcement Corrosion
Authors: Melchers Robert E.
Published: March 2021

The long-term corrosion progression of steel reinforcement is important for estimating the life of reinforced concrete infrastructure. Reviews of field experience and results from recent controlled long-term experiments show that the development of reinforcement corrosion is much more complex than the classical empirical Tuutti model. A new, comprehensive model is proposed, referencing observations and inferences from many field and laboratory observations and built on the bi-modal model for the corrosion of steel. It includes the critical roles of air-voids in the concrete at the concrete-steel interface and the effect of long-term alkali leaching as accelerated by the presence of chlorides. Both are affected by compaction and concrete permeability. The role of chlorides in the early stages is confined to pitting within air-voids. These are critical for allowing initiation to occur, while their size influences the severity of early corrosion. Empirical data show that for seawater with an average water temperature in the range of 10–20 °C, the corresponding rate of long-term corrosion ra is in the range of 0.012–0.015 mm/y.
A Novel Oxide Layer Formed on the 800 °C-Annealed CoMoCrSi Coating Significantly Reduced Friction and Wear at Room Temperature
Authors: Guo Hongjian , Li Bo , Yan Pengxun , Wu Zhiguo
Published: March 2021

In the present work, we investigated the microstructures and properties of as-sprayed and annealed CoMoCrSi coatings. Specifically, the annealed treatment at 800 °C resulted in good recrystallization, improved microstructure, and enhanced properties of CoMoCrSi coatings. An oxide layer formed on the annealed coating surfaces; it was mainly composed of nano-sized Cr2O3 and micro-sized CoMoO4, and could account for the increased surface microhardness and enhanced anti-wear performance of annealed coatings. In particular, the very hard Cr2O3 played a critical role of resisting press-in and wear during the tests, and the CoMoO4 had a lubricating effect during the friction process. Finally, the annealed coatings exhibited low coefficients of friction (COFs) of 0.4 and wear rates of 0.7–0.8 × 10−6 mm3·N−1·m−1 after a long sliding distance of 1000 m at RT. Consequently, the wear mechanism transferred from brittle fracture coupled with abrasive wear for the as-sprayed coating to slight abrasive wear for annealed coatings.
Update on Endometrial Stromal Tumours of the Uterus
Authors: Akaev Iolia , Yeoh Chit Cheng , Rahimi Siavash
Published: March 2021

Endometrial stromal tumours (ESTs) are rare, intriguing uterine mesenchymal neoplasms with variegated histopathological, immunohistochemical and molecular characteristics. Morphologically, ESTs resemble endometrial stromal cells in the proliferative phase of the menstrual cycle. In 1966 Norris and Taylor classified ESTs into benign and malignant categories according to the mitotic count. In the most recent classification by the WHO (2020), ESTs have been divided into four categories: Endometrial Stromal Nodules (ESNs), Low-Grade Endometrial Stromal Sarcomas (LG-ESSs), High-Grade Endometrial Stromal Sarcomas (HG-ESSs) and Undifferentiated Uterine Sarcomas (UUSs). ESNs are clinically benign. LG-ESSs are tumours of low malignant potential, often with indolent clinical behaviour, with some cases presented with a late recurrence after hysterectomy. HG-ESSs are tumours of high malignant potential with more aggressive clinical outcome. UUSs show high-grade morphological features with very aggressive clinical behavior. With the advent of molecular techniques, the morphological classification of ESTs can be integrated with molecular findings in enhanced classification of these tumours. In the future, the morphological and immunohistochemical features correlated with molecular categorisation of ESTs, will become a robust means to plan therapeutic decisions, especially in recurrences and metastatic disease. In this review, we summarise the morphological, immunohistochemical and molecular features of ESTs with particular reference to the most recent molecular findings.
Can Google Translate Rewire Your L2 English Processing?
Authors: Resende Natália , Way Andy
Published: March 2021

In this article, we address the question of whether exposure to the translated output of MT systems could result in changes in the cognitive processing of English as a second language (L2 English). To answer this question, we first conducted a survey with 90 Brazilian Portuguese L2 English speakers with the aim of understanding how and for what purposes they use web-based MT systems. To investigate whether MT systems are capable of influencing L2 English cognitive processing, we carried out a syntactic priming experiment with 32 Brazilian Portuguese speakers. We wanted to test whether speakers re-use in their subsequent speech in English the same syntactic alternative previously seen in the MT output, when using the popular Google Translate system to translate sentences from Portuguese into English. The results of the survey show that Brazilian Portuguese L2 English speakers use Google Translate as a tool supporting their speech in English as well as a source of English vocabulary learning. The results of the syntactic priming experiment show that exposure to an English syntactic alternative through GT can lead to the re-use of the same syntactic alternative in subsequent speech even if it is not the speaker’s preferred syntactic alternative in English. These findings suggest that GT is being used as a tool for language learning purposes and so is indeed capable of rewiring the processing of L2 English syntax.
Scalable, High-Performance, and Generalized Subtree Data Anonymization Approach for Apache Spark
Authors: Bazai Sibghat Ullah , Jang-Jaccard Julian , Alavizadeh Hooman
Published: March 2021

Data anonymization strategies such as subtree generalization have been hailed as techniques that provide a more efficient generalization strategy compared to full-tree generalization counterparts. Many subtree-based generalizations strategies (e.g., top-down, bottom-up, and hybrid) have been implemented on the MapReduce platform to take advantage of scalability and parallelism. However, MapReduce inherent lack support for iteration intensive algorithm implementation such as subtree generalization. This paper proposes Distributed Dataset (RDD)-based implementation for a subtree-based data anonymization technique for Apache Spark to address the issues associated with MapReduce-based counterparts. We describe our RDDs-based approach that offers effective partition management, improved memory usage that uses cache for frequently referenced intermediate values, and enhanced iteration support. Our experimental results provide high performance compared to the existing state-of-the-art privacy preserving approaches and ensure data utility and privacy levels required for any competitive data anonymization techniques.
Emerging Challenges in Smart Grid Cybersecurity Enhancement: A Review
Authors: Mohammadi Fazel
Published: March 2021

In this paper, a brief survey of measurable factors affecting the adoption of cybersecurity enhancement methods in the smart grid is provided. From a practical point of view, it is a key point to determine to what degree the cyber resilience of power systems can be improved using cost-effective resilience enhancement methods. Numerous attempts have been made to the vital resilience of the smart grid against cyber-attacks. The recently proposed cybersecurity methods are considered in this paper, and their accuracies, computational time, and robustness against external factors in detecting and identifying False Data Injection (FDI) attacks are evaluated. There is no all-inclusive solution to fit all power systems requirements. Therefore, the recently proposed cyber-attack detection and identification methods are quantitatively compared and discussed.
Influence of the Fin Shape on Heat Transport in Phase Change Material Heat Sink with Constant Heat Loads
Authors: Bondareva Nadezhda S. , Ghalambaz Mohammad , Sheremet Mikhail A.
Published: March 2021

Nowadays, the heat transfer enhancement in electronic cabinets with heat-generating elements can be achieved using the phase change materials and finned heat sink. The latter allows to improve the energy transference surface and to augment the cooling effects for the heat sources. The present research deals with numerical analysis of phase change material behavior in an electronic cabinet with an energy-generating element. For an intensification of heat removal, the complex finned heat sink with overall width of 10 cm was introduced, having the complicated shape of the fins with width of 0.33 cm and height H = 5 cm. The fatty acid with melting temperature of 46 °C was considered as a phase change material. The considered two-dimensional challenge was formulated employing the non-primitive variables and solved using the finite difference method. Impacts of the volumetric heat flux of heat-generating element and sizes of the fins on phase change material circulation and energy transference within the chamber were studied. It was shown that the presence of transverse ribs makes it possible to accelerate the melting process and reduce the source temperature by more than 12 °C at a heat load of 1600 W/m. It should also be noted that the nature of melting depends on the hydrodynamics of the melt, so the horizontal partitions reduce the intensity of convective heat transfer between the upper part of the region and the lower part.
Historical Indigenous Food Preparation Using Produce of the Three Sisters Intercropping System
Authors: Ngapo Tania M. , Bilodeau Pauline , Arcand Yves , Charles Marie Thérèse , Diederichsen Axel , Germain Isabelle , Liu Qiang , MacKinnon Shawna , Messiga Aimé J. , Mondor Martin , Villeneuve Sébastien , Ziadi Noura , Gariépy Stéphane
Published: March 2021

For centuries, some Indigenous Peoples of the Americas have planted corn, beans and squash or pumpkins together in mounds, in an intercropping complex known as the Three Sisters. Agriculturally, nutritionally and culturally, these three crops are complementary. This literature review aims to compile historical foods prepared from the products of the Three Sisters planting system used in Indigenous communities in the region encompassing southern Quebec and Ontario in Canada, and northeastern USA. The review does not discuss cultural aspects of the Three Sisters cropping system or describe foods specific to any one Indigenous group, but rather, gives an overview of the historical foods stemming from this intercropping system, many foods of which are common or similar from one group to another. Some of the methods of food preparation used have continued over generations, some of the historical foods prepared are the foundation for foods we eat today, and some of both the methods and foods are finding revival.
Anthocyanin Structure and pH Dependent Extraction Characteristics from Blueberries (Vaccinium corymbosum) and Chokeberries (Aronia melanocarpa) in Subcritical Water State
Authors: Kang Hye-Ji , Ko Min-Jung , Chung Myong-Soo
Published: March 2021

This study determines the optimal extraction conditions for the subcritical-water extraction (SWE) of anthocyanin from blueberries and chokeberries and compares the performance using conventional extraction methods. SWE is carried out under different conditions of extraction temperature (110 °C, 130 °C, 150 °C, 170 °C, 190 °C, and 200 °C), extraction time (1, 3, 5, and 10 min), and solvent pH (water and 1% citric acid). The solubility and stability of anthocyanin from blueberries and chokeberries influences the optimal condition for SWE. The presence of more methoxy and hydroxyl functional groups in the basic skeleton of anthocyanin will result in a lower solubility at a high temperature. Water at a higher temperature exhibits a better dissociation reaction, and a solvent has a lower pH at a higher temperature. One percent citric acid is used to reduce the pH of the solvent, which increases the extraction efficiency of anthocyanin in a subcritical water state.
Nutritional Education Is an Effective Tool in Improving Beverage Assortment in Nurseries in Poland
Authors: Harton Anna , Myszkowska-Ryciak Joanna
Published: March 2021

The aim of the study was to assess the impact of education on improving the assortment of beverages served in nurseries in Poland. This analysis focused on beverages served to children with meals and between meals. We examined: water, tea, juices, soft/fruit drinks, compote, milk, cocoa, and coffee substitute. The study involved 93 nurseries enrolled in the Eating Healthy, Growing Healthy project and was conducted from 2015 to 2017. Nutritional education was carried out by dieticians or nutritionists and included 24 h of lectures given to the staff of nurseries. Training was conducted in a form of workshops that were divided into 12 topics. Additionally, consultations regarding infants and young children nutrition were available to the staff. Typically, education training was completed within 1–2 months in each nursery. The effectiveness of education was verified based on data on beverage supply in 186 ten-day menus, 1860 daily inventory reports before (at baseline), and 3–6 months after staff training (post baseline). Data were analyzed in a total group, and separately for public and non-public nurseries. Statistical analyses for categorical variables were done with Chi2 Pearson test. The differences were considered significant at p < 0.05. After education, a significant increase in the supply of water as a beverage served with meals was observed in all nurseries (68% vs. 87%; p = 0.002), both in public (72% vs. 90%, p = 0.036) and non-public (62% vs. 84%, p = 0.017) ones. Moreover, a decrease in served tea was noted: in all nurseries (71% vs. 44%, p < 0.001) and in public nurseries (77% vs. 42%, p < 0.001). Water was available between meals in almost all nurseries. Nutritional education for staff is an important tool for improving adherence to the nutritional recommendation in the case of core beverage supply in Polish nurseries.
Correlation between Androgen Receptor Expression and Immunohistochemistry Type as Prognostic Factors in a Cohort of Breast Cancer Patients: Result from a Single-Center, Cross Sectional Study
Authors: Niță Irina , Nițipir Cornelia , Toma Ștefania Andreea , Limbău Alexandra Maria , Pîrvu Edvina , Bădărău Ioana Anca , Suciu Ioana , Suciu George , Manolescu Loredana Sabina Cornelia
Published: March 2021

Background: We investigated the correlation between the androgen receptor (AR) and immunohistochemistry (IHC) as a prognostic factor in breast cancer (BC). AR is expressed in 60–80% of BC. Methods: We evaluated the prognostic values of AR expression among 143 patients with BC for 36 months. The protocol was amended to measure androgen, estrogen and progesterone receptor expression by IHC and the percentage of hormone positive nuclei was quantified. We determined and quantified the Her2/neu status using IHC and in situ hybridization. The methodology consisted in using a Kaplan–Meier analysis and restricted mean survival time up to 36 months. The principal endpoints of the study were overall survival (OS) and progression free survival (PFS). Results: 57% of patients (n = 82) from our group had AR+ (≥ 1%). Patients with AR+ had better OS, 35.50 vs. 33.40 months, with p = 0.027. Moreover, PFS was prolonged for patients AR+, 32.60 vs. 30.50 months, with p = 0.38. Triple negative breast cancer (TNBC) patients had lower OS and no difference was observed for PFS. Conclusions: Both OS and PFS were favorably influenced by the presence of AR. TNBC had worse outcomes compared with patients with hormonal or/and Her 2/neu positive disease in terms of OS.