bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of canagliflozin on kidney oxygenation evaluated using blood oxygenation level-dependent MRI in patients with type 2 diabetes
Authors: Mori Katsuhito , Inoue Tsutomu , Machiba Yuri , Uedono Hideki , Nakatani Shinya , Ishikawa Masahiro , Taniuchi Satsuki , Katayama Yutaka , Yamamoto Akira , Kobayashi Naoki , Kozawa Eito , Shimono Taro , Miki Yukio , Okada Hirokazu , Emoto Masanori
Published: August 2024

Background

Recent clinical studies suggest protective effects of SGLT2 inhibitors on kidney disease outcome. Chronic hypoxia has a critical role in kidney disease development, thus we speculated that canagliflozin, an SGLT2 inhibitor, can improve kidney oxygenation.

Methods

A single-arm study was conducted to investigate the effects of canagliflozin on T2* value, which reflects oxygenation level, in patients with type 2 diabetes (T2D) using repeated blood oxygenation level-dependent MRI (BOLD MRI) examinations. Changes in cortical T2* from before (Day 0) to after single-dose treatment (Day 1) and after five consecutive treatments (Day 5) were evaluated using 12-layer concentric objects (TLCO) and region of interest (ROI) methods.

Results

In the full analysis set (n=14 patients), the TLCO method showed no change of T2* with canagliflozin treatment, whereas the ROI method found that cortical T2* was significantly increased on Day 1 but not on Day 5. Sensitivity analysis using TLCO in 13 well-measured patients showed that canagliflozin significantly increased T2* on Day 1 with no change on Day 5, whereas a significant improvement in cortical T2* following canagliflozin treatment was found on both Day 1 and 5 using ROI.

Conclusions

Short-term canagliflozin treatment may improve cortical oxygenation and lead to better kidney outcomes in patients with T2D.
Mucosal immunity in upper and lower respiratory tract to MERS-CoV
Authors: Shrwani Khalid J. , Mahallawi Waleed H. , Mohana Abdulrhman I. , Algaissi Abdullah , Dhayhi Nabil , Sharwani Nouf J. , Gadour Eyad , Aldossari Saeed M. , Asiri Hasan , Kameli Nader , Asiri Ayad Y. , Asiri Abdullah M. , Sherwani Alaa J. , Cunliffe Nigel , Zhang Qibo
Published: August 2024

Introduction

Middle East respiratory syndrome coronavirus (MERS-CoV) has emerged as a deadly pathogen with a mortality rate of up to 36.2%. MERS-CoV can cause severe respiratory tract disease and multiorgan failure. Therefore, therapeutic vaccines are urgently needed. This intensive review explores the human immune responses and their immunological mechanisms during MERS-CoV infection in the mucosa of the upper and lower respiratory tracts (URT and LRT, respectively).

Objective

The aim of this study is to provide a valuable, informative, and critical summary of the protective immune mechanisms against MERS-CoV infection in the URT/LRT for the purpose of preventing and controlling MERS-CoV disease and designing effective therapeutic vaccines.

Methods

In this review, we focus on the immune potential of the respiratory tract following MERS-CoV infection. We searched PubMed, Embase, Web of Science, Cochrane, Scopus, and Google Scholar using the following terms: “MERS-CoV”, “B cells”, “T cells”, “cytokines”, “chemokines”, “cytotoxic”, and “upper and lower respiratory tracts”.

Results

We found and included 152 studies in this review. We report that the cellular innate immune response, including macrophages, dendritic cells, and natural killer cells, produces antiviral substances such as interferons and interleukins to prevent the virus from spreading. In the adaptive and humoral immune responses, CD4+ helper T cells, CD8+ cytotoxic T cells, B cells, and plasma cells protect against MERS-CoV infection in URT and LRT.

Conclusion

The human nasopharynx-associated lymphoid tissue (NALT) and bronchus-associated lymphoid tissue (BALT) could successfully limit the spread of several respiratory pathogens. However, in the case of MERS-CoV infection, limited research has been conducted in humans with regard to immunopathogenesis and mucosal immune responses due to the lack of relevant tissues. A better understanding of the immune mechanisms of the URT and LRT is vital for the design and development of effective MERS-CoV vaccines.
Morphologic characterization and cytokine response of chicken bone-marrow derived dendritic cells to infection with high and low pathogenic avian influenza virus
Authors: Mo Jongsuk , Segovia Karen , Chrzastek Klaudia , Briggs Kelsey , Kapczynski Darrell R.
Published: August 2024

Dendritic cells (DCs) are professional antigen-presenting cells, which are key components of the immune system and involved in early immune responses. DCs are specialized in capturing, processing, and presenting antigens to facilitate immune interactions. Chickens infected with avian influenza virus (AIV) demonstrate a wide range of clinical symptoms, based on pathogenicity of the virus. Low pathogenic avian influenza (LPAI) viruses typically induce mild clinical signs, whereas high pathogenic avian influenza (HPAI) induce more severe disease, which can lead to death. For this study, chicken bone marrow-derived DC (ckBM-DC)s were produced and infected with high and low pathogenic avian influenza viruses of H5N2 or H7N3 subtypes to characterize innate immune responses, study effect on cell morphologies, and evaluate virus replication. A strong proinflammatory response was observed at 8 hours post infection, via upregulation of chicken interleukin-1β and stimulation of the interferon response pathway. Microscopically, the DCs underwent morphological changes from classic elongated dendrites to a more general rounded shape that eventually led to cell death with the presence of scattered cellular debris. Differences in onset of morphologic changes were observed between H5 and H7 subtypes. Increases in viral titers demonstrated that both HPAI and LPAI are capable of infecting and replicating in DCs. The increase in activation of infected DCs may be indicative of a dysregulated immune response typically seen with HPAI infections.
Intranasal HD-Ad-FS vaccine induces systemic and airway mucosal immunities against SARS-CoV-2 and systemic immunity against SARS-CoV-2 variants in mice and hamsters
Authors: Zhou Peter , Watt Jacqueline , Mai Juntao , Cao Huibi , Li Zhijie , Chen Ziyan , Duan Rongqi , Quan Ying , Gingras Anne-Claude , Rini James M. , Hu Jim , Liu Jun
Published: August 2024

The outbreak of coronavirus disease 19 (COVID-19) has highlighted the demand for vaccines that are safe and effective in inducing systemic and airway mucosal immunity against the aerosol transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this study, we developed a novel helper-dependent adenoviral vector-based COVID-19 mucosal vaccine encoding a full-length SARS-CoV-2 spike protein (HD-Ad-FS). Through intranasal immunization (single-dose and prime-boost regimens), we demonstrated that the HD-Ad-FS was immunogenic and elicited potent systemic and airway mucosal protection in BALB/c mice, transgenic ACE2 (hACE2) mice, and hamsters. We detected high titers of neutralizing antibodies (NAbs) in sera and bronchoalveolar lavages (BALs) in the vaccinated animals. High levels of spike-specific secretory IgA (sIgA) and IgG were induced in the airway of the vaccinated animals. The single-dose HD-Ad-FS elicited a strong immune response and protected animals from SARS-CoV-2 infection. In addition, the prime-boost vaccination induced cross-reactive serum NAbs against variants of concern (VOCs; Beta, Delta, and Omicron). After challenge, VOC infectious viral particles were at undetectable or minimal levels in the lower airway. Our findings highlight the potential of airway delivery of HD-Ad-FS as a safe and effective vaccine platform for generating mucosal protection against SARS-CoV-2 and its VOCs.
A bibliometric analysis of blue carbon (1993–2023): evolution of research hot topics and trends
Authors: Wang Shanshan , Yan Dandan , Wang Chenhao , Wu Linlin , Huang Yiming
Published: August 2024

Blue carbon refers to the carbon fixed in marine ecosystems such as mangroves, salt marshes, and seagrass beds. Considered a treasure house for capturing and storing carbon dioxide, it can alleviate environmental issues linked to climate change and positively influence the environments where people live. Thus, to clarify the hotspots and development trends of blue carbon research, bibliometric analysis incorporating ScientoPy and VOSviewer software were used to quantitatively analyze 4,604 blue carbon publications from Web of Science and Scopus databases between 1993 and 2023. The results indicate a rapidly growing number of published studies on blue carbon, with blue carbon research being multifaceted and gradually becoming an interdisciplinary and international topic. This study on blue carbon, which is based on keyword clustering analysis, comprises three stages. The analysis of the strength of the cooperative connections between scholars in various countries who have published work on blue carbon. found that the cooperation networks of developed countries are strong and those of developing countries are relatively weak. Quantitative trend analysis reveals a growing focus on the restoration and conservation of blue carbon ecosystems, with remote sensing being the predominant technology used in the blue carbon research field in recent years. In blue carbon research, increasing carbon sequestration capacity, climate change mitigation, and carbon sequestration in macroalgae remain potential hotspots for research and development.
Translation and cultural adaptation of the COVID-19 Yorkshire Rehabilitation Scale into German
Authors: Sperl Lisa , Stamm Tanja , Mosor Erika , Ritschl Valentin , Sivan Manoj , Hoffmann Kathryn , Gantschnig Brigitte
Published: August 2024

Background

Experts estimate that in up to 10% of the infected, SARS-CoV-2 would cause persistent symptoms, activity limitations and reduced quality of life. Referred to as long COVID, these conditions might, in the future, specifically impact German-speaking countries due to their higher rates of unvaccinated people compared to other Western countries. Accurate measurement of symptom burden and its consequences is needed to manage conditions such as long COVID, and several tools have been developed to do so. However, no patient-reported instrument existed in the German language at the time of writing.

Objective

This study, therefore, aimed to develop a German version of the COVID-19 Yorkshire Rehabilitation Scale (C19-YRS).

Methods

We conducted a translation and qualitative evaluation, including cultural adaptation, of the C19-YRS and assessed its face validity. After creating a preliminary version, 26 individuals (14 women [53%]) participated in cognitive interviews (January 2022 to March 2022). Using cognitive debriefing interviews, we ensured the content’s comprehensibility. The matrix-framework method guided the qualitative data analysis.

Results

Compared to the original English version, adaptations were necessary, resulting in changes to the introductory text, while the items for recording persistent symptoms were hardly changed.

Conclusion

The German version of the C19-YRS is expected to support standardized long COVID care.
Next move in movement disorders: neuroimaging protocols for hyperkinetic movement disorders
Authors: Dalenberg Jelle R. , Peretti Debora E. , Marapin Lenny R. , van der Stouwe A. M. Madelein , Renken Remco J. , Tijssen Marina A. J.
Published: August 2024

Introduction

The Next Move in Movement Disorders (NEMO) study is an initiative aimed at advancing our understanding and the classification of hyperkinetic movement disorders, including tremor, myoclonus, dystonia, and myoclonus-dystonia. The study has two main objectives: (a) to develop a computer-aided tool for precise and consistent classification of these movement disorder phenotypes, and (b) to deepen our understanding of brain pathophysiology through advanced neuroimaging techniques. This protocol review details the neuroimaging data acquisition and preprocessing procedures employed by the NEMO team to achieve these goals.

Methods and analysis

To meet the study’s objectives, NEMO utilizes multiple imaging techniques, including T1-weighted structural MRI, resting-state fMRI, motor task fMRI, and 18F-FDG PET scans. We will outline our efforts over the past 4 years to enhance the quality of our collected data, and address challenges such as head movements during image acquisition, choosing acquisition parameters and constructing data preprocessing pipelines. This study is the first to employ these neuroimaging modalities in a standardized approach contributing to more uniformity in the analyses of future studies comparing these patient groups. The data collected will contribute to the development of a machine learning-based classification tool and improve our understanding of disorder-specific neurobiological factors.

Ethics and dissemination

Ethical approval has been obtained from the relevant local ethics committee. The NEMO study is designed to pioneer the application of machine learning of movement disorders. We expect to publish articles in multiple related fields of research and patients will be informed of important results via patient associations and press releases.
Epithelioid inflammatory myofibroblastic sarcoma treated with Alectinib: a case report and literature review
Authors: Wu Xinchun , Zhu Junxi , Yan Yichao , Niu Dongfeng , Chen Lin , Ning Ning , Zhang Yankai
Published: August 2024

Epithelioid inflammatory myofibroblastic sarcoma (EIMS) is an extremely rare and aggressive form of inflammatory myofibroblastic tumor. Clinically, it has a high risk of relapse and peripheral organ infiltration, and it responds poorly to conventional chemotherapy. Anaplastic lymphoma kinase (ALK) inhibitors are currently the most effective targeted therapy for EIMS. This report discusses a typical case of abdominal EIMS in a 43-year-old woman. The tumors recurred rapidly within one month after surgery. Alectinib was promptly administered upon diagnosis. However, the patient developed a severe allergic reaction to the medication. After a comprehensive assessment and symptomatic treatment, her condition stabilized, leading to a favorable prognosis. This study summarizes cases of abdominal EIMS, highlights the successful use of Alectinib for treatment, and discusses the management of medication-related complications.
Generation of a medicine food homology formula and its likely mechanism in treatment of microvascular angina
Authors: Jin Zhidie , Liu Mingwang , Xie Beili , Wen Wei , Yan Yuxin , Zhang Yangfang , Li Haohao , Shen ZhengYu , Jiang Lulian , Gao Mengjie , Chen Keji , Zhao Fuhai
Published: August 2024

Microvascular angina (MVA) is the most common cause of cardiac ischemic chest pain in patients without obstructive coronary artery disease (CAD) and lacks of effective treatment means. Medicine food homology (MFH) involves substances with both nutritional and medicinal qualities that have the potential to improve MVA symptoms as medicines, dietary supplements. However, research on MFH formula (MFHF) for MVA is not available. The study aims to generate a core MFHF for MVA through data mining and offer scientific backing for the utilization of edible medications in the prevention and alleviation of MVA. 11 databases were utilized to construct a database of MFH drugs, and the MFHF was generated through frequency analysis, association rule analysis, and clustering analysis. The composition of the formula is Codonopsis Radix, Astragali Radix, Platycodonis Radix, Persicae Semen, Glycyrrhizae Radix Et Rhizoma, Angelicae Sinensis Radix, and Allii Macrostemonis Bulbus. Through network pharmacology and molecular docking, we identified five major active components of MFHF: Adenosine, Nonanoic Acid, Lauric Acid, Caprylic Acid, and Enanthic Acid, along with nine core targets (NFKB1, ALB, AKT1, ACTB, TNF, IL6, ESR1, CASP3, and PTGS) for the improvement of MVA. These 5 active components have various biological activities, such as reducing oxidative stress, anti-inflammation, analgesia effect, inhibiting platelet aggregation, vasodilatation, vascular endothelial protection, and cardio-protection. GO and KEGG enrichment analyses revealed that MFHF mainly acted on the response to xenobiotic stimulus, integrative component of the plasma membrane, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding, pathways in cancer, lipid and atherosclerosis, human cytomegalovirus infection, and the PI3K-Akt signaling pathway, which are the main pathogenesis of MVA.
Acute generalized exanthematous pustulosis induced by icotinib: a case report and literature review
Authors: Yang Wei , Zhao Jiayu , Niu Jun
Published: August 2024

Acute generalized exanthematous pustulosis, an infrequent adverse drug reaction, mainly results from drugs. Clinically, acute generalized exanthematous pustulosis manifests as a high fever, with skin lesions of small monomorphic subcorneal sterile pustules on an erythematous that presents at 1–4 days after medication exposure. The incidence of acute generalized exanthematous pustulosis varies from 3/1, 000, 000 to 5/1, 000, 000, while the mortality rate is typically around 5%. We present a case of a 69-year-old female who developed a diffuse, erythematous, pustular rash over the entire body and exhibited a fever of 38.3°C after 4 days of icotinib therapy. Considering her medication history and the appearance of the lesions, she was diagnosed with acute generalized exanthematous pustulosis and received appropriate treatment. We also conducted a literature review through PubMed to compare similarities and differences between our case and those reported in the literature.
Does chronic ankle instability patients lead to changes in biomechanical parameters associated with anterior cruciate ligament injury during landing? A systematic review and meta-analysis
Authors: He Zhanyang , Zhu Houwei , Ye Binyong , Zheng Zhe , Liu Gongju , Pan Huiju , Liu Ronghua
Published: August 2024

Objective

This study aimed to determine if patients with chronic ankle instability (CAI) exhibit biomechanical changes associated with the increased risk of anterior cruciate ligament (ACL) injury during landing tasks.

Study Design

This study was conducted through systematic review and meta-analysis.

Data Sources

Searches were conducted in May 2024 across five electronic databases, including Web of Science, Scopus, PubMed, SPORTDiscus, and Cochrane Library.

Eligibility Criteria

Studies were included if they (1) involved subjects with CAI and healthy controls and (2) assessed biomechanical variables such as ground reaction forces, joint angles, and joint torques.

Results

Of the 675 identified studies, 171 were included in the review, and 13 were eligible for meta-analysis. The reviewed studies clearly defined research objectives, study populations, consistent participant recruitment, and exposures, and they used valid and reliable measures for outcomes. However, areas such as sample size calculation, study sample justification, blinding in assessments, and addressing confounders were not robust. This meta-analysis involved 542 participants (healthy group: n = 251; CAI group: n = 291). Compared with healthy individuals, patients with CAI exhibited a greater peak vertical ground reaction force (peak VGRF; SMD = 0.30, 95% CI: 0.07–0.53,p= 0.009), reduced hip flexion angles (SMD = −0.30, 95% CI: −0.51 to −0.17,p< 0.0001), increased trunk lateral flexion (SMD = 0.47, 95% CI: 0.05 to 0.9,p= 0.03), greater hip extension moments (SMD = 0.47, 95% CI: 0.09–0.84,p= 0.02), and increased knee extension moments (SMD = 0.39, 95% CI: 0.02–0.77,p= 0.04).

Conclusion

During landing tasks, patients with CAI demonstrate increased hip extension moments and knee extension moments, decreased hip flexion angles, increased peak VGRF, and increased trunk lateral flexion angles. These biomechanical variables are associated with an elevated risk of ACL injuries.

Systematic Review Registration:

Identifier CRD42024529349.
Plants’ molecular behavior to heavy metals: from criticality to toxicity
Authors: El-Sappah Ahmed H. , Zhu Yumin , Huang Qiulan , Chen Bo , Soaud Salma A. , Abd Elhamid Mohamed A. , Yan Kuan , Li Jia , El-Tarabily Khaled A.
Published: August 2024

The contamination of soil and water with high levels of heavy metals (HMs) has emerged as a significant obstacle to agricultural productivity and overall crop quality. Certain HMs, although serving as essential micronutrients, are required in smaller quantities for plant growth. However, when present in higher concentrations, they become very toxic. Several studies have shown that to balance out the harmful effects of HMs, complex systems are needed at the molecular, physiological, biochemical, cellular, tissue, and whole plant levels. This could lead to more crops being grown. Our review focused on HMs’ resources, occurrences, and agricultural implications. This review will also look at how plants react to HMs and how they affect seed performance as well as the benefits that HMs provide for plants. Furthermore, the review examines HMs’ transport genes in plants and their molecular, biochemical, and metabolic responses to HMs. We have also examined the obstacles and potential for HMs in plants and their management strategies.
Regression in the service of bibliotherapy—What can “Captain Underpants” teach us?
Authors: Ifrah Sarit
Published: August 2024

Regression in the service of the ego is a unique phenomenon that often occurs within therapeutic settings. In the current study1, I show how it emerges within child therapy and how bibliotherapy manages to give it presence and thus to process it. The methodology that guided this study was based on a critical reading of psychoanalysis and bibliotherapy theories. In addition, the methodology is based on a therapeutic vignette aimed at demonstrating the qualities of bibliotherapy with children. I claim that bibliotherapy, based as it is primarily on the use of reading and writing processes, offers additional ways of processing and thinking about this phenomenon. The study provides an innovative contribution that is related to the interdisciplinary approach to therapy. There are important links between the two major disciplines examined in this study, psychoanalysis and bibliotherapy. Their intertwining generates interrelations and mutual inspiration. Moreover, this study adds to the theoretical and practical foundation of bibliotherapy and further establishes the understanding regarding the power of reading and writing processes to “relate the soul” within the analytical process.
Processing of misinformation as motivational and cognitive biases
Authors: Zhou Yanmengqian , Shen Lijiang
Published: August 2024

Misinformation can be broadly defined as false or inaccurate information created and spread with or without clear intent to cause harm. It travels fast and deep and persists despite debunking. It is well-documented that corrective messages and fact-checking efforts often fail to mitigate the effects or persistence of misinformation. In this article, we examine the persistence of misinformation as rooted in motivational and cognitive biases in information processing. While drawing on the frameworks of motivations that drive information seeking, sharing, and processing and various cognitive biases, we explicate mechanisms and processes that underlie the impact and persistence of misinformation. We conclude our article by discussing the potential utility of psychological inoculation as a prebunking strategy.
Retrospective analysis of lithium treatment: examination of blood levels
Authors: Uskur Tuğçe , Güven Oya , Tat Mustafa
Published: August 2024

Introduction

Lithium is a key medication for treating various neuropsychiatric disorders, with a narrow therapeutic index and significant drug interactions. Monitoring lithium blood levels is crucial. This study aims to investigate the relationship between lithium blood levels and demographic characteristics such as age and gender, as well as possible drug interactions, in patients with a history of lithium use who applied to various services and outpatient clinics.

Materials & methods

The files of 438 patients who were admitted to various services and outpatient clinics of Kırklareli Training and Research Hospital between January 1 and December 31, 2023, were retrospectively reviewed. Patients’ blood lithium levels, gender, age, service/outpatient clinic they admitted to, other medications used, urea, creatinine, and eGFR values were recorded.

Results

When the demographic characteristics of 438 patients were examined, 62% were female (270), 38% were male (168), and the average age was 46.3 ± 14.8 years, showing a normal distribution. It was found that 192 patients (71 males, 121 females) had therapeutic lithium blood levels, while 244 patients (97 males, 147 females) had levels below 0.6 mmol/L. Two female patients had blood levels above the therapeutic range (1.23 and 1.43 mmol/L). Among the clinics and services, the four most frequented were the psychiatry clinic (314 patients), internal medicine clinic (36 patients), emergency service (27 patients), and medical oncology clinic (17 patients). Of the 314 patients admitted to the psychiatry clinic, 168 had therapeutic drug levels; only 7 of the 36 admitted to internal medicine had therapeutic levels; 12 of the 27 patients in the emergency service had therapeutic levels; and all 17 patients in medical oncology had levels below therapeutic limits.

Discussion

The data emphasize the importance of regular blood level monitoring to ensure lithium treatment’s efficacy and patient safety. It is noteworthy that most patients in the psychiatry clinic had therapeutic drug levels, while those in other clinics had lower levels.

Conclusion

In conclusion, this study highlights the importance of regular blood level monitoring to ensure the efficacy and safety of lithium treatment.
Radiologic overview of sinonasal lesions
Authors: Syed Mohammed U. , Stephen Steve J. , Rahman Akm A.
Published: August 2024

Sinonasal tumors are often malignant and comprise approximately 3% of all head and neck malignancies. Half of these tumors arise in the nasal cavity, and other common locations of origin include the ethmoid and maxillary sinuses. Some unique clinical features are anosmia and altered phonation but the most common general features include headache, epistaxis, and diplopia. CT and MRI may be used to assess tumor location, invasion of adjacent tissue, presence of metastasis, internal tumor heterogeneity, and contrast enhancement. Local invasion of the tumor beyond the sinonasal tract can impact adjacent structures such as the cranial nerves, skull base, branches of the internal carotid artery, and orbit leading to neurologic signs, facial pain, and diplopia. Imaging is used in the diagnosis, staging, and treatment planning of sinonasal tumors. This collection of benign and malignant sinonasal tumors will include some rare and unique cases with an emphasis on imaging features demonstrating a wide variety of pathologies.
“The Razor’s Edge of Timing:” A Phenomenological Analysis of Decision-Making Processes Surrounding Medical Aid in Dying
Authors: Currin-McCulloch Jennifer , Gallo Nathan , Wang Yixuan , Mooney Kim
Published: August 2024

Objectives

The study aimed to explore how terminally ill individuals in the United States approach medical aid in dying (MAID), including personal, interpersonal and structural factors that influence their decision-making processes.

Methods

This embodied phenomenological study incorporated semi-structured (N = 9) interviews with seven terminally ill adults who received a prescription for MAID. Interviews occurred over Zoom between October 2021-January 2023 and was guided by Ashworth’s framework for exploring phenomenological lifeworlds. Participants were invited to share perceptions of their lifeworlds in pursuit of MAID including values; embodied health, ability, and emotions; space and place in society; reflections on time/timing; and political and cultural discourse. Data analysis integrated Wertz’s phenomenological psychological analysis methods.

Results

The phenomenon of choosing MAID is an intricate juggling of lifeworlds between participants’ embodied relationships, values, time and agency which lead to co-existing experiences of uncertainty and hard-won relief.

Conclusion

Our findings contribute cutting-edge knowledge of the decisional tensions and triumphs terminally ill individuals encounter as they approach MAID and highlight practical implications for health and mental health providers in preparing psychoeducational support for those seeking MAID.
Research on Robot Control Technology of Tomato Plant Lowering in Greenhouses
Authors: Zhang Bin , Xu Shuhao , Xiong Ziming , Qin Hao , Ai Xinyi , Yuan Ting , Li Wei
Published: August 2024

Currently, tomato plant lowering is performed manually, which is both inefficient and costly. The manual process presents challenges in terms of efficiency and cost, creating a need for automated solutions in greenhouse environments. This paper addresses this issue by presenting the design and development of a tomato-plant-lowering robot utilizing machine vision and deep learning techniques. The study includes the design of an end effector optimized for plant-lowering operations based on the physical characteristics of tomato vines and roller hooks; precise positioning of roller hooks achieved through kinematic analysis and a custom dataset; integration of the RepC3 module from RT-DETR with YOLOv5s for enhanced object detection and positioning; and real-time camera feed display through an integrated application. Performance evaluation through experimental tests shows improvements in recognition accuracy, positioning precision, and operational efficiency, although the robot’s success rate in leaf removal needs further enhancement. This research provides a solid foundation for future developments in plant-lowering robots and offers practical insights and technical guidance.
The Profile of Bacterial Infections in a Burn Unit during and after the COVID-19 Pandemic Period
Authors: Musuroi Corina , Musuroi Silvia-Ioana , Baditoiu Luminita , Crainiceanu Zorin , Muntean Delia , Voinescu Adela , Izmendi Oana , Sirmon Alexandra , Licker Monica
Published: August 2024

Infections represent a major complication for burn-injured patients. The aim of this study was to highlight the changes in the incidence and antimicrobial resistance of bacterial strains isolated from burn patients, at the end of the COVID-19 pandemic, in relation to the antibiotics used during the pandemic. A comparative analysis of the demographic data and the microorganisms identified in the clinical samples of two groups of burn patients admitted to a university hospital in Romania was carried out. The first group consisted of 48 patients and the second of 69 patients, hospitalized in January–August 2020 and 2023, respectively. The bacterial species with the highest incidence were S. aureus, A. baumannii, Pseudomonas spp. The significant changes between 2023 and 2020 are reflected in the increase in the frequency of non-fermentative Gram-negative bacteria, especially S. maltophilia, and the increase in antimicrobial resistance of Pseudomonas and Klebsiella spp. Klebsiella spp. did not change in frequency (7%), but there was a significant increase in the incidence of K. pneumoniae strains with pan-drug resistant behaviour to antibiotics (40%), including colistin. The phenomenon can be explained by the selection of specimens carrying multiple resistance genes, as a result of antibiotic treatment during the COVID-19 period. The post-pandemic antimicrobial resistance detected in burn patients indicates the need for permanent surveillance of the resistance trends, primarily due to the limited therapeutic options available for these patients.
The Appropriateness of Empirical Uses of Antibiotics Based on Antimicrobial Susceptibility Results for Inpatients at a Tertiary Hospital in Saudi Arabia
Authors: Almogbel Yasser , Mobark Mugahid A. , Almutairi Masaad S. , Almogbel Faisal S. , Rabbani Syed I. , Alhathloul Sultan , Alamro Shada , Alatallah Lateefah
Published: August 2024

The optimal use of antibiotics represents a cornerstone in controlling antibiotic resistance. Strategies such as antibiotic stewardship programs (ASPs) have been developed to influence the rational use of antibiotics. This study evaluated the appropriateness of the empirical use of antibiotics based on antibiotic susceptibility results with the aim of participating effectively in improving local ASPs. In a cross-sectional study conducted at a tertiary hospital in Saudi Arabia, 500 inpatients received empirical antibiotics, and their culture and sensitivity results were included. The appropriateness of the empirical use of antibiotics was determined based on their alignment with the culture and sensitivity results. More than half of the participants (56.4%) were men, and nearly half (43%) were over 61 years old. The empirical uses of antibiotics were appropriately prescribed in 58% of the patients. Ciprofloxacin and ceftriaxone were the most prescribed antibiotics, while vancomycin, piperacillin–tazobactam, and tigecycline were the most appropriately prescribed antibiotics. E. coli was the main microorganism isolated in the susceptibility results and was appropriately prescribed in 59% of the patients. The highest microbial sensitivity was observed for linezolid, vancomycin, and tigecycline. Antibiotics were appropriately prescribed empirically in more than half of the participants. Activating interventional ASP is crucial to fill the gap in prescribing antimicrobials. Considering the expected type of organisms and the local susceptibility pattern is likely to yield a more appropriate empirical use of antibiotics.
Analysis of Antibiotic Resistance Genes (ARGs) across Diverse Bacterial Species in Shrimp Aquaculture
Authors: Mitchell Tilden M. , Ho Tin , Salinas Liseth , VanderYacht Thomas , Walas Nikolina , Trueba Gabriel , Graham Jay P.
Published: August 2024

There is little information available on antibiotic resistance (ABR) within shrimp aquaculture environments. The aim of this study was to investigate the presence of antibiotic resistance genes (ARGs) in shrimp farming operations in Atacames, Ecuador. Water samples (n = 162) and shrimp samples (n = 54) were collected from three shrimp farming operations. Samples were cultured and a subset of isolates that grew in the presence of ceftriaxone, a third-generation cephalosporin, were analyzed using whole-genome sequencing (WGS). Among the sequenced isolates (n = 44), 73% of the isolates contained at least one ARG and the average number of ARGs per isolate was two, with a median of 3.5 ARGs. Antibiotic resistance genes that confer resistance to the β-lactam class of antibiotics were observed in 65% of the sequenced isolates from water (20/31) and 54% of the isolates from shrimp (7/13). We identified 61 different ARGs across the 44 sequenced isolates, which conferred resistance to nine antibiotic classes. Over half of all sequenced isolates (59%, n = 26) carried ARGs that confer resistance to more than one class of antibiotics. ARGs for certain antibiotic classes were more common, including beta-lactams (26 ARGs); aminoglycosides (11 ARGs); chloramphenicol (three ARGs); and trimethoprim (four ARGs). Sequenced isolates consisted of a diverse array of bacterial orders and species, including Escherichia coli (48%), Klebsiella pneumoniae (7%), Aeromonadales (7%), Pseudomonadales (16%), Enterobacter cloacae (2%), and Citrobacter freundii (2%). Many ARGs were shared across diverse species, underscoring the risk of horizontal gene transfer in these environments. This study indicated the widespread presence of extended-spectrum β-lactamase (ESBL) genes in shrimp aquaculture, including blaCTX-M, blaSHV, and blaTEM genes. Increased antibiotic resistance surveillance of shrimp farms and identification of aquaculture operation-level risk factors, such as antibiotic use, will likely be important for mitigating the spread of ARGs of clinical significance.
MILP-Based Approach for High-Altitude Region Pavement Maintenance Decision Optimization
Authors: Bo Wu , Qian Zhendong , Yu Bo , Ren Haisheng , Yang Can , Zhao Kunming , Zhang Jiazhe
Published: August 2024

Affected by climatic factors (e.g., low temperature and intense ultraviolet radiation), high-altitude regions experience numerous pavement diseases, which compromise driving safety and negatively impact user travel experience. Timely planning and execution of pavement maintenance are particularly critical. In this paper, considering the characteristics of pavement maintenance in high-altitude regions (e.g., volatility of traffic volume, seasonality of maintenance timing, and fragility of the ecological environment), we aim to derive optimal monthly maintenance plans. We develop a multi-objective nonlinear optimization model that comprehensively accounts for minimizing maintenance costs, affected traffic volume and carbon emissions, and maximizing pavement maintenance effectiveness. Utilizing linearization methods, the model is reconstructed into a typical mixed-integer linear programming (MILP) model, enabling it to be solved directly using conventional solvers. We consider five types of decision strategies to reflect the preferences of different decision-makers. Given the uncertainty of maintenance costs, we also utilize the robust optimization method based on the acceptable objective variation range (AOVR) to construct a robust optimization model and discuss the characteristics of optimistic, robust, and pessimistic solutions. The results suggest that different decision strategies show differences in the indicators of maintenance costs, affected traffic volume, carbon emissions, and pavement performance. When multiple decision objectives are comprehensively considered, the indicators are between the maximum and minimum values, which can effectively balance the decision needs of maintenance effectiveness, maintenance timing, and environmental protection. The number of maintenance workers, the requirement of the minimum pavement condition index (PCI), and the annual budget influence the maintenance planning. The obtained robust solution can somewhat overcome the conservative nature of the pessimistic solution. The method proposed in this paper helps address the complexities of pavement maintenance decisions in high-altitude regions and provides guidance for pavement maintenance decisions in such areas.
A Review on Soil Moisture Dynamics Monitoring in Semi-Arid Ecosystems: Methods, Techniques, and Tools Applied at Different Scales
Authors: Duarte Efrain , Hernandez Alexander
Published: August 2024

Soil moisture (SM) plays a crucial role in land–atmosphere interaction systems, directly influencing evapotranspiration, photosynthesis, and the water dynamics of the soil surface. Invariably, SM is negatively impacted by disturbances such as fires, which are becoming more frequent across semi-arid ecosystems. Different ecological restoration activities have been implemented to mitigate the impacts of disturbance that, when left untreated, can worsen the effects of recurrent droughts and accelerate desertification and land degradation processes. To measure and monitor the dynamics of SM, advanced techniques and tools have been developed that integrate remote sensing and in situ measurement. This review encompasses various themes on the application of remote sensing for measuring and monitoring SM dynamics in semi-arid ecosystems at different scales. We focused our analysis on the western United States region and thus have developed a review on the following topics: (a) the different data sources (e.g., satellite, unmanned aerial vehicles), (b) approaches to measure field-based SM, and (c) algorithms and techniques to model SM at different scales. We summarize these topics by emphasizing repeatable approaches for the transparent estimation of this variable, identifying current data gaps, and highlighting future trends to fulfill the expanding demand for SM monitoring strategies.
Energy-Conserving Explicit Relaxed Runge–Kutta Methods for the Fractional Nonlinear Schrödinger Equation Based on Scalar Auxiliary Variable Approach
Authors: Zhao Yizhuo , Li Yu , Zhu Jiaxin , Cao Yang
Published: August 2024

In this paper, we present a novel explicit structure-preserving numerical method for solving nonlinear space-fractional Schrödinger equations based on the concept of the scalar auxiliary variable approach. Firstly, we convert the equations into an equivalent system through the introduction of a scalar variable. Subsequently, a semi-discrete energy-preserving scheme is developed by employing a fourth-order fractional difference operator to discretize the equivalent system in spatial direction, and obtain the fully discrete version by using an explicit relaxed Runge–Kutta method for temporal integration. The proposed method preserves the energy conservation property of the space-fractional nonlinear Schrödinger equation and achieves high accuracy. Numerical experiments are carried out to verify the structure-preserving qualities of the proposed method.
Second-Life Assessment of Commercial LiFePO4 Batteries Retired from EVs
Authors: Cao Zhi , Gao Wei , Fu Yuhong , Turchiano Christopher , Vosoughi Kurdkandi Naser , Gu Jing , Mi Chris
Published: August 2024

LiFePO4 (LFP) batteries are well known for their long cycle life. However, there are many reports of significant capacity degradation in LFP battery packs after only three to five years of operation. This study assesses the second-life potential of commercial LFP batteries retired from electric vehicles (EVs) by evaluating their aging characteristics at the cell and module levels. Four LFP cells and four modules were subjected to aging tests under various conditions. The results indicate that LFP cells exhibit long life cycles with gradual capacity degradation and a minimal internal resistance increase. Module-level analysis reveals significant balance issues impacting capacity recovery. Incremental capacity analysis (ICA) and post-mortem analysis identify the loss of active materials and lithium inventory as key aging mechanisms. This study provides the optimal working conditions of second-life LFP batteries and suggests that, with proper balancing systems, LFP batteries can achieve extended second-life use in stationary energy storage applications, emphasizing the importance of effective balance management for sustainable battery utilization.
Effects of Small and Normalized Q-Factor Changes and Knee Alignment on Knee Biomechanics during Stationary Cycling
Authors: Wilbert Jacob , Brown Sean , Weinhandl Joshua T. , Tatarski Rachel , Zhang Songning
Published: August 2024

Increasing inter-pedal distance (Q-Factor: QF) in cycling increases peak internal knee abduction moments (KAbM). The effect of smaller and normalized changes in QF has not been investigated. The purposes of this study were to examine changes in KAbM with small and normalized increases and whether static knee alignment accounts for any changes in knee biomechanics in cycling. Fifteen healthy participants were included (age: 22.7 ± 2.5 years, BMI: 23.95 ± 3.21 kg/m2). Motion capture and instrumented pedals collected kinematic and pedal reaction force (PRF) data, respectively, while participants cycled at five different QFs. Each participant’s mechanical axis angle (MAA) was estimated using motion capture. Each participant’s QFs were normalized by starting at 160 mm and increasing by 2% of the participant’s leg length (L), where the five QF conditions were as follows: QF1 (160), QF2 (160 + 0.02 × L), QF3 (160 + 0.04 × L), QF4 (160 + 0.06 × L), and QF5 (160 + 0.08 × L). A linear mixed model was performed to detect differences between QF conditions. KAbM increased by more than 30% in QF5 from QF1, QF2, QF3, and QF4. Medial PRF increased by at least 20% in QF5 from QF1, QF2, and QF3. MAA had varying degrees of correlation with the variables of interest. These results suggest that KAbM is more sensitive to changes in QF at greater QF increases.
Perineuronal Net Alterations Following Early-Life Stress: Are Microglia Pulling Some Strings?
Authors: Rahimian Reza , Belliveau Claudia , Simard Sophie , Turecki Gustavo , Mechawar Naguib
Published: August 2024

The extracellular matrix plays a key role in synapse formation and in the modulation of synaptic function in the central nervous system. Recent investigations have revealed that microglia, the resident immune cells of the brain, are involved in extracellular matrix remodeling under both physiological and pathological conditions. Moreover, the dysregulation of both innate immune responses and the extracellular matrix has been documented in stress-related psychopathologies as well as in relation to early-life stress. However, the dynamics of microglial regulation of the ECM and how it can be impacted by early-life adversity have been understudied. This brief review provides an overview of the recent literature on this topic, drawing from both animal model and human post mortem studies. Direct and indirect mechanisms through which microglia may regulate the extracellular matrix—including perineuronal nets—are presented and discussed in light of the interactions with other cell types.
A Sustainability Assessment of Industrialised Housing Construction Using the MIVES (Modelo Integrado de Valor para una Evaluación Sostenible)-Based Multicriteria Decision-Making Method
Authors: Medrán Francisco , Enfedaque Alejandro , Alberti Marcos G.
Published: August 2024

Recently, the world population surpassed 8000 million people. Providing housing for such a large population poses a great challenge for the building industry and its impact on the planet. The rise in the urban population leads to greater impacts not only on the environment but also on economies and societies. Consequently, reducing these externalities is mandatory to preserve the welfare of the world. One way of optimising the economic cost of housing is through industrialising the production of housing. However, a balance between housing optimisation and the management of the social/environmental impacts has not yet been achieved. In order to bridge this gap, in this study, a holistic evaluation of several housing systems was performed using the MIVES (“Modelo Integrado de Valor para una Evaluación Sostenible”)-based multicriteria decision-making method (MCDM method). Moreover, the obtained results were compared, showing which industrialised building technique might enhance the sustainability of housing production.
Spatial Effectiveness in High-Rise Timber Towers: A Global Perspective
Authors: Ilgın Hüseyin Emre , Aslantamer Özlem Nur
Published: August 2024

High-rise timber structures signify a rising trend, thanks to their significant environmental and economic advantages that occur over their complete lifespan. Enhancing spatial effectiveness in these structures is a critical design consideration for project feasibility. Currently, there has been no comprehensive study on the space efficiency of such towers. This article analyzed 79 cases all over the world to deepen the knowledge of design features shaping spatial efficiency. The critical findings are as follows: (1) the most common architectural preferences include residential function, a centrally located service core, and prismatic arrangements; (2) the preferred structural material is composite, while a shear walled frame system is the favored structural system; (3) the average spatial efficiency and percentage of core area to GFA were recorded at 84% and 10%, ranging from the lowest values of 70% and 4% to the highest values of 95% and 21%, respectively; and (4) no significant differences were detected in the effect of core design approaches on spatial effectiveness if appropriately planned, with similar inferences drawn concerning form and the structural material used. This article will assist in developing design directions for different interested parties, including architectural designers taking part in the advancement of high-rise timber towers.