bluuebunny/crossref_metadata_2025 huggingface dataset:
Departamento de Caldas: Anexo 6
Authors: Londoño Londoño Julián Alberto , Salazar Aguilar José Fernando , Rincón Novoa Rubiela , Mateus Rodríguez Julián Fernando , Osorio Cardona Jairo Antonio
Published: March 2024

El presente documento se preparo con el fin de proveer información básica a nivel departamental del desempeño sectorial, sus vínculos con la orientación de la ciencia , la tecnología, la innovación y las demandas del sector sobre conocimiento técnico para focalizar la investigación publica, articular capacidades, aunar esfuerzos para superar problemas productivos, mejorar la competitividad y aprovechar oportunidades del mercado en distintas cadenas de productividad priorizadas en el departamento
Immersive Technologies for Depression Care: Scoping Review
Authors: Reategui-Rivera C Mahony , Villarreal-Zegarra David , De La Cruz-Torralva Kelly , Díaz-Sánchez Paquita , Finkelstein Joseph
Published: March 2024

Background

Depression significantly impacts quality of life, affecting approximately 280 million people worldwide. However, only 16.5% of those affected receive treatment, indicating a substantial treatment gap. Immersive technologies (IMTs) such as virtual reality (VR) and augmented reality offer new avenues for treating depression by creating immersive environments for therapeutic interventions. Despite their potential, significant gaps exist in the current evidence regarding the design, implementation, and use of IMTs for depression care.

Objective

We aim to map the available evidence on IMT interventions targeting depression treatment.

Methods

This scoping review followed a methodological framework, and we systematically searched databases for studies on IMTs and depression. The focus was on randomized clinical trials involving adults and using IMTs. The selection and charting process involved multiple reviewers to minimize bias.

Results

The search identified 16 peer-reviewed articles, predominantly from Europe (n=10, 63%), with a notable emphasis on Poland (n=9, 56%), which contributed to more than half of the articles. Most of the studies (9/16, 56%) were conducted between 2020 and 2021. Regarding participant demographics, of the 16 articles, 5 (31%) exclusively involved female participants, and 7 (44%) featured participants whose mean or median age was >60 years. Regarding technical aspects, all studies focused on VR, with most using stand-alone VR headsets (14/16, 88%), and interventions typically ranging from 2 to 8 weeks, predominantly in hospital settings (11/16, 69%). Only 2 (13%) of the 16 studies mentioned using a specific VR design framework in planning their interventions. The most frequently used therapeutic approach was Ericksonian psychotherapy, used in 56% (9/16) of the studies. Notably, none of the articles reported using an implementation framework or identified barriers and enablers to implementation.

Conclusions

This scoping review highlights the growing interest in using IMTs, particularly VR, for depression treatment but emphasizes the need for more inclusive and comprehensive research. Future studies should explore varied therapeutic approaches and cost-effectiveness as well as the inclusion of augmented reality to fully realize the potential of IMTs in mental health care.
Barriers to COVID-19 Vaccination in a Troop of Fleet Antiterrorism Security Team Marines: Observational Study (Preprint)
Authors: Blazek E Susanne , Bucher Amy
Published: March 2024

BACKGROUND

In 2019, the World Health Organization declared the reluctance to vaccinate despite the availability of vaccination services as one of the top 10 threats to global health. In early 2021, self-reported reluctance to vaccinate among military personnel might have been considered a significant threat to national security. Having a choice architecture that made COVID-19 vaccination optional rather than required for military personnel could have inadvertently undermined military readiness if vaccination uptake did not reach an acceptable threshold.

OBJECTIVE

The purpose of this observational study was to examine Marines’ self-reported reasons for planning to decline the COVID-19 vaccine to understand their barriers to vaccination.

METHODS

As the vaccination became available to 1 company of Fleet Antiterrorism Security Team (FAST) Marines in early 2021, company command required those planning to decline vaccination to write an essay with up to 5 reasons for their choice. These essays provided the data for this study. Qualitative descriptive analysis with elements from grounded theory was used to thematically categorize FAST Marines’ written reasons for planning to decline the COVID-19 vaccine into a codebook describing 8 key behavioral determinants. Interrater agreement among 2 qualitatively trained researchers was very good (κ=0.81).

RESULTS

A troop of 47 Marines provided 235 reasons why they planned to decline the COVID-19 vaccine. The most frequent reasons were difficulty understanding health information (105/235, 45%), low estimates of risk (33/235, 14%), and fear of physical discomfort (29/235, 12%). Resulting interventions directly targeted Marines’ self-reported reasons by reducing barriers (eg, normalized getting the vaccine), increasing vaccine benefits (eg, improved access to base gyms and recreational facilities), and increasing nonvaccine friction (eg, required in writing 5 reasons for declining the vaccine).

CONCLUSIONS

Understanding the barriers military personnel experience toward COVID-19 vaccination remains critical as vaccine acquisition and availability continue to protect military personnel. Insights from subpopulations like FAST Marines can enhance our ability to identify barriers and appropriate intervention techniques to influence COVID-19 vaccination behaviors.
Labeling Radiology Report With GPT-4 Prompt Engineering: Comparative Study of in-Context Prompting (Preprint)
Authors: Kim Songsoo , Kim Donghyun , Shin Hyunjoo , Kim Jaewoong , Yoon Dukyong
Published: March 2024

BACKGROUND

Large language models, such as Generative Pre-trained Transformer-4 (GPT-4), utilize a method known as in-context learning, which enhances the model's responses by understanding the context provided within the input text.

OBJECTIVE

This study aims to assess the labeling efficacy of Generative Pre-trained Transformer-4 in radiology reports and to validate the performance enhancement through in-context learning.

METHODS

In this retrospective study, radiology reports were obtained utilizing the Medical Information Mart for Intensive Care III (MIMIC-III) database, and the reports were manually labeled by two radiologists for performance evaluation. Two experimental prompts were defined for comparison: the “Basic prompt,” which included sections for “Task” and “Output,” and the “In-context prompt,” which added a “Context” section for additional information. Labeling experiments were conducted on head CT reports for multi-label classification of ten predefined labels (mass, hemorrhage, infarct, vascular, white matter, volume loss, hydrocephalus, pneumocephalus, foreign body, and fracture) - Experiment 1. Labeling abdomen CT reports for multi-label classification of actionable findings based on four different sections (gastrointestinal, genitourinary, musculoskeletal, and vascular) - Experiment 2. Precision, recall, F1-scores, and accuracy were compared between the two prompting scenarios.

RESULTS

In Experiment 1, for most labels, In-context prompts demonstrated a notable improvement in F1 scores (up to 0.658) and accuracy (up to 0.155), except for hemorrhage and pneumocephalus labels. Statistically significant differences were observed in four labels (vascular, hydrocephalus, mass, foreign body). For Experiment 2, the In-context prompt significantly enhanced F1 scores (by up to 0.306) and accuracy (by up to 0.107) across all labels, compared to Basic prompts.

CONCLUSIONS

Our study demonstrated that Generative Pre-trained Transformer-4 with prompt engineering has commendable performance in various labeling tasks in real-world radiology reports. It offers a flexible, researcher-tailored approach to labeling tasks using in-context learning.
Effects of Smart Goggles Used Before Bed on Objectively Measured Sleep and Self-Reported Anxiety, Stress, and Relaxation: A Pilot Study (Preprint)
Authors: Danoff-Burg Sharon , Gottlieb Elie , Weaver Morgan A. , Karmon Kiara C. , Lara Ledesma Duvia , Rus Holly M.
Published: March 2024

BACKGROUND

Insufficient sleep is a problem affecting millions. Poor sleep can instigate or worsen anxiety and, conversely, anxiety can lead to or exacerbate poor sleep. Advances in innovative consumer products designed to promote relaxation and support healthy sleep are emerging and their effectiveness can be evaluated accurately using sleep measurement technologies in the home environment.

OBJECTIVE

This study examined the effects of smart goggles used before bed to deliver gentle, slow vibration to the eyes and temples. Objective sleep, perceived sleep, and self-reported stress, anxiety, and relaxation were measured at home by adults with subclinical threshold sleep problems.

METHODS

A within-subjects, pre-post design was implemented. Healthy adults reporting suboptimal sleep (N=20) tracked their sleep nightly using a PSG-validated non-contact biomotion device and completed questionnaires daily and nightly for 6 weeks (3 weeks baseline, 3 weeks intervention). During the baseline period, participants slept at home as usual. During the intervention period, participants used Therabody SmartGoggles in Sleep mode before bed. This mode delivers gentle eye and temple massage through vibrating motors for relaxation.

RESULTS

Multilevel regression analysis of 676 nights of objective data showed improvements during nights when using the goggles, relative to baseline, in sleep duration (+12 minutes, P=.014); deep sleep, measured in duration (+6 minutes, P=.002), proportion of the night (7% relative increase, P=.020), and BodyScore (4% increase, P=.002); number of nighttime awakenings (7% decrease, P=.021); total time awake at night after sleep onset (-6 minutes, P=.047); and SleepScore, a measure of overall sleep quality (3% increase, P=.020).

Questionnaire data showed that, compared to baseline, participants felt they had better sleep quality (P<.001) and felt more well-rested upon waking (P<.001). Furthermore, immediately after using the goggles each night, compared to immediately before, participants reported feeling sleepier, less stressed, less anxious, and more relaxed (all Ps<.05). A standardized inventory administered before and after the 3-week intervention period indicated reduced anxiety, confirming the nightly analysis (P=.03).

CONCLUSIONS

Objectively measured sleep quality and duration, as well as perceived sleep, improved when using the goggles before bed compared to baseline. Participants also reported increased feelings of relaxation along with reduced stress and anxiety. Future research expanding on this pilot study is warranted to confirm the preliminary evidence presented in this brief report.
Patient Perspectives on AI for Mental Health Care: Cross-Sectional Survey Study (Preprint)
Authors: Benda Natalie , Desai Pooja , Reza Zayan , Zheng Anna , Kumar Shiveen , Harkins Sarah , Hermann Alison , Zhang Yiye , Joly Rochelle , Kim Jessica , Pathak Jyotishman , Reading Turchioe Meghan
Published: March 2024

BACKGROUND

The application of artificial intelligence (AI) to health and health care is rapidly increasing. Several studies have assessed the attitudes of health professionals, but far fewer studies have explored the perspectives of patients or the general public. Studies investigating patient perspectives have focused on somatic issues, including those related to radiology, perinatal health, and general applications. Patient feedback has been elicited in the development of specific mental health care solutions, but broader perspectives toward AI for mental health care have been underexplored.

OBJECTIVE

This study aims to understand public perceptions regarding potential benefits of AI, concerns about AI, comfort with AI accomplishing various tasks, and values related to AI, all pertaining to mental health care.

METHODS

We conducted a 1-time cross-sectional survey with a nationally representative sample of 500 US-based adults. Participants provided structured responses on their perceived benefits, concerns, comfort, and values regarding AI for mental health care. They could also add free-text responses to elaborate on their concerns and values.

RESULTS

A plurality of participants (245/497, 49.3%) believed AI may be beneficial for mental health care, but this perspective differed based on sociodemographic variables (all P<.05). Specifically, Black participants (odds ratio [OR] 1.76, 95% CI 1.03-3.05) and those with lower health literacy (OR 2.16, 95% CI 1.29-3.78) perceived AI to be more beneficial, and women (OR 0.68, 95% CI 0.46-0.99) perceived AI to be less beneficial. Participants endorsed concerns about accuracy, possible unintended consequences such as misdiagnosis, the confidentiality of their information, and the loss of connection with their health professional when AI is used for mental health care. A majority of participants (80.4%, 402/500) valued being able to understand individual factors driving their risk, confidentiality, and autonomy as it pertained to the use of AI for their mental health. When asked who was responsible for the misdiagnosis of mental health conditions using AI, 81.6% (408/500) of participants found the health professional to be responsible. Qualitative results revealed similar concerns related to the accuracy of AI and how its use may impact the confidentiality of patients’ information.

CONCLUSIONS

Future work involving the use of AI for mental health care should investigate strategies for conveying the level of AI’s accuracy, factors that drive patients’ mental health risks, and how data are used confidentially so that patients can determine with their health professionals when AI may be beneficial. It will also be important in a mental health care context to ensure the patient–health professional relationship is preserved when AI is used.
Investigating the Impact of Modern Educational Technology on Improving Human Resources with the Mediating Role of Information Literacy of Physical Education Teachers in the 2nd District of Karaj
Authors: Moharramzadeh Mehrdad , Moharramzadeh Nasser , Mahdavi Akbar
Published: March 2024

The aim of the research was the effect of modern educational technology on the improvement of human resources with the mediating role of information literacy of physical education teachers in the 2nd district of Karaj. The descriptive-analytical research method was field method. The current research community is 265 physical education teachers of Karaj District 2. The sample size of the present study was determined to be 265 people. The measurement tools included modern educational technology questionnaires (Yavuz, 2005), human resource improvement questionnaire (Volba and Jansen, 2010) and information literacy questionnaire (Siamak & Daverpanah, 2015). The content and form validity of the questionnaires were confirmed by the professors, and then Cronbach’s alpha reliability of the modern educational technology questionnaire was 0.70, Cronbach’s alpha reliability of the human resource improvement questionnaire was 0.81, and Cronbach’s alpha reliability of the information literacy questionnaire was 0.76. In order to analyze the data of the present research, structural equation modeling method was used. The entire process of analysis was done using spss19 and Amose23 software. The findings of the research showed that information literacy plays a mediating role in the impact of modern educational technology on the improvement of human resources. Therefore, it can be concluded that if human resources have sufficient information literacy, modern educational technology can create an environment that enriches the educational environment, skills, behavior, learning style and improvement of human resources.
An Analysis on the Development of Online Art Sales Industry and the Sustained Competitive Advantages of its Players Based on Porter’s Five Forces Model
Authors: Tian Naxi
Published: March 2024

The rapid growth of online art sales post-2010 necessitates an examination of industry trends and competitive dynamics. This study investigates the current competitive structure, highlighting the need for online art platforms to cultivate trust and innovate technologically to thrive in a crowded market. Adopting a mixed methodology combining The Platform Economy and Long Tail Theory, the research identifies strengths and weaknesses, revealing parallels with e-commerce retail. Industry analysis, employing Porter’s Five Forces Model, uncovers competition intensity, while a case study on artnet utilizes the VRIO Model to assess sustainable advantages. Traffic metrics and qualitative insights from an interview with a platform representative supplement quantitative data, informing recommendations for enhancing market efficiency and adaptability. Data was sourced from websites and a questionnaire-based email interview.
25 лет в роли системного интегратора станкостроения
Authors: Самодуров К.В.
Published: March 2024

Отрасль станкоинструментальной промышленности к на‑
чалу 90‑х годов прошлого столетия была одной из ведущих
отраслей народного хозяйства СССР и занимала второе-тре‑
тье места в рейтинге стран, производящих и потребляющих
оборудование и инструмент. В эти годы особенно быстро
наращивался выпуск прогрессивных высокопроизводитель‑
ных станков и КПО с числовым программным управлени‑
ем. К 1990 году объем выпуска металлообрабатывающего
оборудования достиг более 80 тыс. шт. В том числе 22 тыс.
станков и прессов с ЧПУ и 5 тыс. обрабатывающих цен‑
тров и гибких производственных линий.
Impacts of Justice Collaborator Revocation from Prisoner Remissions for Extraordinary Crimes in Class 1 Correctional Facilities in Tangerang
Authors: Amiludin Amiludin , Dias Saputra Muhamad , Bukhari Razif Imran , Nurfauziah Ahmad Dwi
Published: March 2024

The elimination of Justice Collaborator as a requirement for an Extraordinary Crime convict to obtain sentence reduction or remission, in accordance with the provisions stated in the Minister of Law and Human Rights Regulation Number 7 of 2022, which amends the Minister of Law and Human Rights Regulation Number 3 of 2018 regarding the requirements and procedures for granting sentence reduction, has changed the mechanism for granting remission to prisoners at Class 1 Tangerang Correctional Institution, both in terms of administrative and subjective requirements. This change has both positive and negative impacts on the existing regulations. The research methodology employed is empirical legal research, as it relates to the effectiveness of the law. The recommendations obtained are related to communication, education, and transparency regarding the implementation of Minister of Law and Human Rights Regulation Number 7 of 2022 at Class 1 Tangerang Correctional Institution, in order to be accepted and understood by the inmates, their families, and relevant stakeholders
A detailed research on Antioxidant and therapeutic potential of Immuxanth implementing in silico and in vitro approach
Authors: Dutta Rajdeep Dutta Gopal , Kar Gautam , Rao Seema
Published: March 2024

Imuuxanth powder, a dietary supplement enriched with natural antioxidants, is explored for its nutritional properties and potential health benefits. The powder provides 5.26 Kcal energy, 1.90g protein, zero fat and added sugar, and 1.80g fiber per serving. Suitable for low-calorie diets, it supports protein intake, tissue repair, and muscle development. With no fat or added sugar, it aids weight management and blood sugar control. Amino acid analysis highlights its diverse essential and non-essential amino acids. GC-MS identifies flavonoids, xanthones, and carotenoids for antioxidant properties.

Antioxidant assays (DPPH, FRAP, ABTS) confirm Imuuxanth's potential to combat oxidative stress. Molecular docking studies predict interactions with proteins related to antioxidant effects. Top berries intensify its antioxidant activity due to active compounds. Imuuxanth powder presents promising nutritional properties, including low energy, moderate protein, and absence of fat and added sugar. Its diverse bioactive compounds contribute to potent antioxidant capabilities. In silico studies support its potential as a dietary supplement for overall health, warranting further research for specific benefits.

Keywords: Immuxanth powder, Antioxandant potential, GCMS Analysis, Nutritional Analysis, Insilico Analysis
A Case Report of a Male with Systemic Lupus Erythematous with First Presentation of Annular Macular Itchy Rashes on his Extremities
Authors: Alouthmani Alyaa , ALakkad Ashraf , Ramli Samar , Eldegwy Marwa
Published: March 2024

Background: Systemic lupus erythematosus (SLE) is an idiopathic autoimmune disease which impacts multiple organs and has various clinical presentations. Among all the organs, the skin is the most frequently affected.

Case Presentation: This case report presents a 34-year-old male who presented with severe, itchy, and painful rashes over his right arm and both legs, along with a history of pigmented skin lesions. Initially, the patient was given corticosteroid creams by a dermatologist, but the condition progressed, requiring further investigation. The patient's medical history revealed hypertension and, on review, signs of rashes, fatigue, and arthralgias were noted.

Physical examination indicated mild swelling and tenderness in both knees. Additionally, an examination revealed his skin was warm, he had fast capillary refill (<2 seconds), and he had an erythematic rash on the right arm and both legs. A nodular erythema rash was seen on the left leg, along with pigmented skin lesions on the right leg, including a bigger lesion measuring approximately 2.5 cm. Laboratory results indicated increased creatinine, low white blood cell count, anemia, and abnormal protein levels, raising doubts about SLE. Further tests confirmed a raised level of autoantibodies, low complement levels, and positive lupus-related antibodies.

Later, the patient was referred to a rheumatologist and an SLE diagnosis was confirmed based on laboratory results and hematological manifestations, mucocutaneous involvement, and lupus nephritis. Treatment initially started with hydroxychloroquine and prednisolone, then tests were repeated and the patient underwent a renal biopsy that revealed focal segmental glomerulosclerosis. He was again prescribed methylprednisolone and prednisolone for three days. The patient's condition resolved and he made a successful recovery.

Conclusion: This case demonstrates the multiple clinical manifestations of SLE, the necessity of in-depth investigations, and the requirement for multidisciplinary care to address the intricacies of organ involvement in the disease.
The Comprehensive Review: Exploring Future Potential of Nasopulmonary Drug Delivery Systems for Nasal Route Drug Administration
Authors: Pal Rahul , Pandey Prachi , Koli Manju , Srivastava Khushi , Tiwari Vaisanavi , Gaur Aman Kumar , Dutta Prottay
Published: March 2024

This comprehensive review aims to explore the future potential of nasopulmonary drug delivery systems for the administration of drugs through the nasal route. Nasal drug delivery has gained significant attention due to its numerous advantages, including rapid absorption, avoidance of first-pass metabolism, and non-invasive administration. This review provides an overview of the nasal anatomy and physiology, highlighting the factors influencing drug absorption and bioavailability. Additionally, it discusses the various types of nasopulmonary drug delivery systems, such as nasal sprays, powders, and gels, along with their advantages and limitations. Furthermore, the review delves into the challenges associated with nasal drug delivery, including mucociliary clearance, nasal irritation, and formulation issues. The potential applications of nasopulmonary drug delivery systems in the treatment of various diseases, such as allergies, respiratory disorders, and systemic conditions, are also discussed. Finally, the review concludes with an outlook on the future prospects of nasopulmonary drug delivery systems, emphasising the need for further research and development to optimise their efficacy and safety.

Keywords: nasal pulmonary; nasal spray; nasal mucosa; gels; drops; nasal approaches; nasal route; nasal delivery.
Blood Pressure in Relation to Age and Gender
Authors: Hussainy Syed Areefulla , Shereen Shaima
Published: March 2024

Hypertension is a disease defined as persistently elevated arterial blood pressure (BP) with systolic blood pressure of less than 120 mm Hg and diastolic blood pressure of less than 80 mm Hg. Age is one the most common predictor and non-modifiable risk factor of hypertension. Hypertension is more common among older adults than adults of 40-59 years of age. Gender is another common non-modifiable risk factor of hypertension. On average, hypertension is more common among men than in women. A Prospective observational study was carried out where all the patients of either sex attending general medicine department with established hypertension above 35 years of age were included. A Chi-square test was used to find a significant association between age & gender with hypertension. A p value of or lower than 0.05 was considered to be statistically significant. Majority of the patients 65% were males and 35% were females and common age group was ≥60 years. CNS disorders were found in majority of the patients. Diuretics were the most prescribed class of drugs. There was a steady rise in the number of hypertensive patients with increase in age. Hypertension was more prevalent among males than in females. Factors like age and gender were found to be statistically significant associated with hypertension. Clinical pharmacist at an early stage need to monitor the BP and related risk factors and achieve the therapeutic goals, thereby enhancing the quality life span of the patient.

Keywords: Hypertension, Gender, Age distribution, Clinical Pharmacist, Statistical, Blood Pressure
Design, Synthesis, Characterization and Biological Evaluation of Novel Depsides as Potential Antibacterials
Authors: More Manoj Kumari
Published: March 2024

Sixteen depsides were synthesized to screen for their antibacterial activity. All of them were reported for the first time. Their chemical structures were clearly determined by FTIR, 1H NMR, ESI mass spectra. All the compounds were assayed for antibacterial and antifungal activities against two Gram-positive bacterial strains (Bacillus subtilis ATCC 6633) and (Staphylococcus aureus ATCC 29747)and two gram-negative bacterial strains (Escherichia coli ATCC 8739) and (Pseudomonas aeruginosa ATCC 25619) the MIC and zone of inhibition calculated by cup-plate method and serial dilution method and two fungal strains (Aspergillus niger ATCC 90292) and (Candida albicans ATCC 24433)by the micro-broth dilution method.Compound2-(2- propoxy -2-oxoethylphenyl (4-methoxyphenyl)acetate(P6) and 2-(2- propoxy-2-oxoethylphenyl(4-methylphenyl)acetate(P7) showed powerful antibacterial activities against E. coli with MIC of 2.0 40mg/ml while compound 2-(2- propoxy -2-oxoethylphenyl(4-methylphenyl)acetate (P7) and 2-(2- propoxy -2-oxoethylphenyl and (3-methoxyphenyl)acetate (P8) exhibited significant antibacterial activities against B. subtilis with MIC of 3.12 40mg/ml, which were superior to the positive controls amoxycillin trihydrate and ciprofloxacin HCl, respectively and compound 2-(2- propoxy -2-oxoethyl) phenyl 4-methylbenzoate (P8) was found to have highest antifungal activity against Candida albicans ATCC 24433. On the basis of the biological results, quantitative structure activity relationships were discussed.

Keywords: Depsides, Antibacterials, Antifungal, Quantitative structure activity relationship.
Therapeutic potential of Nankhawah/Ajwain (Tracyspermum ammi Linn): A comprehensive review article
Authors: Naaz Afifa , Wani Ghulam Nabi , Begum Wajeeha , Fathima Shavana
Published: March 2024

Background: Trachyspermum ammi Linn., commonly known as ajwain, is a widely recognized spice and medicinal plant originating from Egypt but cultivated across regions such as Iraq, Iran, Afghanistan, Pakistan, and India. Belonging to the Apiaceae family, this species offers diverse pharmacological benefits due to its rich chemical constituents.

Objectives: This review aims to summarize the traditional and contemporary applications of Trachyspermum ammi, focusing on its ethnobotanical description, chemical composition, and pharmacological aspects.

Methodology: The literature search encompassed scientific databases and publications covering the historical usage, chemical profiling, and biological activities of Trachyspermum ammi.

Results: Trachyspermum ammi exhibits a variety of pharmacological activities, including antifungal, antioxidant, antimicrobial, antinociceptive, antispasmodic, carminative, diuretic, aphrodisiac, and anthelmintic properties. Traditionally, it has been employed to treat conditions such as flatulence, atonic dyspepsia, diarrhea, abdominal tumors, abdominal pain, piles, bronchial issues, lack of appetite, galactogogue, asthma, and amenorrhea as it possesses properties of Muhallil, Mudirr-i-Bawl-o-Hayd, Dafa e Tafun, Jali, Habis etc. Modern research supports these claims while also revealing its potential in treating kidney stones, abortion, and aflatoxin detoxification.

Conclusion: Trachyspermum ammi holds great promise as a natural resource for novel therapies, owing to its extensive array of bioactive components and established pharmacological effects. Further investigation into its mechanisms of action and optimization of extraction techniques could lead to more efficient utilization of this valuable medicinal plant.

Keywords: Ajwain, Nankhawah, Trachyspermum Ammi Linn, Mudirr-i-Bawl-o-Hayd, Hazim, Thymol, Appetizer.
ANALYSIS OF SOME HEAVY METALS LEVEL IN ISPARTA'S DRINKING WATER USING UV SPECTROPHOTOMETRY AND PRINCIPAL COMPONENT REGRESSION
Authors: AKTAŞ A. Hakan , Gençer İlknur
Published: March 2024

Background: Heavy metals, which are likely to be found in natural water samples, can cause some discomfort when taken into the body in high amounts. The aim of this study is to create complexes of iron, copper and cadmium, which are major heavy metals that can be found in natural water samples, with ammonium pyrrolidine dithiocarbamate (APDC) chelate, to analyze these complexes with UV-Spectrophotometry after the optimum conditions to be created in water samples, and to apply the principal component regression chemometric method to the data obtained here.
Method: In the applied spectrophotometric method, complexes of each heavy metal were first formed with APDC. Then, appropriate mixtures of these complexes were prepared and their spectra were recorded. Principal component regression chemometric method was applied to the data obtained.
Results: Very consistent results of the chemometric method applied to the data obtained in the spectrophotometric analysis of the complexes of the heavy metals studied after providing optimum conditions were observed.
Conclusion: It can be stated that the method developed in the research and the chemometric method applied to the data obtained from here can be easily applied in routine water analysis.
                      
Peer Review History:
Received 10 December 2023;   Revised 29  January 2024; Accepted 3 March; Available online 15 March 2024
Academic Editor: Dr. Emmanuel O. Olorunsola, Department of Pharmaceutics & Pharmaceutical Technology, University of Uyo, Nigeria, olorunsolaeo@yahoo.com
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Dr. Dennis Amaechi, MrsFoluBabade Mini Estate , Flat 5 by Old Soldiers Quarter, Sabongari/Bwari, Abuja- Federal Capital Territory, Nigeria. amaechitoexcel@yahoo.com 
Dr. Wafa Mohamed Al Madhagi, Sana’a University, Yemen, walmadhaji1983@gmail.com
Prof. Cyprian Ogbonna ONYEJI, Obafemi Awolowo University, Ile-Ife, Nigeria, conyeji@oauife.edu.ng
HUBUNGAN DUKUNGAN ORANG TUA DENGAN RESILIENSI AKADEMIK PADA REMAJA SMP NEGERI DI KECAMATAN NGRAMBE
Authors: Aini Putri Nur
Published: March 2024

AbstrakÂ Penelitian ini dilaksanakan berdasarkan fenomena pemberlakuan pembelajaran daring yang dilaksanakan saat pandemi Covid-19 pada sejumlah peserta didik. Akibatnya, peserta didik harus melaksanakan aktivitas belajar di rumah yang kurang memiliki dukungan dari orang tua atau kurang dalam ketahanan bidang akademik menjadi mudah bosan, jenuh, bahkan stress karena menghadapi situasi yang sulit. Adapun tujuan dari penelitian ini yaitu untuk mengetahui hubungan antara dukungan orang tua dengan resiliensi akademik pada remaja di SMP Negeri Kecamatan Ngrambe. Jenis penelitian adalah penelitian kuantitatif korelasional. Teknik pengambilan sampel yang digunakan adalah teknik cluster sampling dan proportional random sampling dengan sampel penelitian 275 siswa. Metode pengumpulan data menggunakan skala psikologi dengan 35 butir untuk variabel dukungan orang tua dan 36 butir untuk variabel resiliensi akademik. Metode analisis data menggunakan analisis deskriptif dan uji spearman rank. Penelitian ini memperoleh hasil bahwa tingkat dukungan orang tua maupun resiliensi akademik berada pada kategori sedang dengan persentase 42%. Terdapat hubungan positif yang signifikan, dengan derajat korelasi yang kuat antara dukungan orang tua dengan resiliensi akademik remaja SMP Negeri di Kecamatan Ngrambe yakni sebesar 0,721 dengan signifikansi 0,000 (<0,005). Artinya, semakin tinggi dukungan orang tua terhadap siswa, maka semakin tinggi pula resiliensi akademiknya, dan sebaliknya semakin rendah dukungan orang tua terhadap siswa, maka semakin rendah pula resiliensi akademiknya.Keywords: Dukungan Orang Tua, Resiliensi Akademik, Remaja
Netherton Syndrome -- a therapeutic challenge in childhood
Authors: Kostova Polina , Petrova Guergana , Shahid Martin , Papochieva Vera , Miteva Dimitrinka , Yordanova Ivelina , Drenovska Kossara , Bradinova Irena , Janniger Camila K. , Schwartz Robert A. , Vassileva Snejina
Published: March 2024

Netherton syndrome (NS) is a rare autosomal recessive genodermatosis
(OMIM #256500) characterized by superficial scaling, atopic
manifestations, and multisystemic complications. It is caused by
loss-of-function mutations in the SPINK5 gene, which encode a key
kallikrein protease inhibitor. There are two subtypes of the syndrome
that differ in clinical presentation and immune
Yodai - a new variety of grass pea (Lathyrus sativus L.)
Authors: Kosev Valentin , Vasileva Viliana , Popovic Vera
Published: March 2024

The biological performance of grass pea (Lathyrus sativus L.) hybrid lines
[LHL (BGE027129 ? LA5108), LHL-2 (BGE025277 ? LA5108) and LHL-3 (LA5108 ?
BGE027129]) and their parental components (BGE027129, BGE025277 and LA5108
varieties) were studied in a three-year field experiment. Biometric analysis
of each variety and line was done for main quantitative traits and
phenological stages and periods. The height of the plants at the
technological maturity of the grain reached 46 cm. The vegetation period has
an average duration of 93 days. New variety Yodai was created, which was
obtained by multiple individual selection from the cross BGE027129 ? LA5108
(line LHL). The new variety ripens 4-5 days before the varieties BGE027129
and LA5108. On average, 13 well-fed pods per plant were formed with a total
of 22 normally developed seeds. The seeds were medium-large with a white
seed coat, with a flat oval shape. The seed productivity (4.41 g/plant)
exceeds the average of the parental varieties (3.80 g/plant). The weight of
1000 seeds was about 172 g. The crude protein content was 23.85%. In
addition, the variety has good resistance to cracking of the pods. It is
drought tolerant and weakly attacked by diseases and enemies. In 2022, by
the decision of the Expert Commission at the Executive Agency for Variety
Testing, Field Inspection and Seed Control, Bulgaria (appointed by order
RD-10-1/14.01.2022) and by order No. RD-14-3 of 02.03.2022, the Yodai
variety was recognized as new and original.
Assessing urban growth in Greater Surabaya using Google Earth Engine: An evaluation of built-up area expansion in Indonesian secondary cities
Authors: Purwono Nugroho , Susetyo Danang , Rijal Seftiawan , Syaripah Gina , Munawaroh Siti
Published: March 2024

Urbanization in Indonesia's cities is increasing, leading to various impacts, including negative consequences due to insufficient investment in local public infrastructure. Urbanization assessment primarily relies on examining changes in built-up areas over the past decade. These changes serve as an indicator that can be effectively derived from remote sensing data. In our study, we applied remote sensing data from the Google Earth Engine (GEE) catalog to delve into the urbanization dynamics within Greater Surabaya area, Indonesia. We employed satellite imagery from Landsat 7 Enhanced Thematic Mapper Plus (ETM+) and Landsat 8 Operational Land Imager and Thermal Infrared Sensor (OLI TIRS) for 2012 and 2022. We used Support Vector Machine (SVM) classification techniques to construct precise urban expansion models. Our analysis revealed distinct urban expansion trends in Mojokerto and Sidoarjo, which contrast with the relatively stable urban development trends in northern Surabaya due to the construction of toll roads. The findings provide valuable inputs for urban management, necessitating targeted interventions and strategies to address the urbanization disparities between these two areas. It underscores the critical importance of resource allocation, infrastructure development, and urban planning initiatives, with a specific focus on Gresik, to ensure sustainable urban growth and mitigate potential challenges associated with rapid expansion.
The power of light – From dental materials processing to diagnostics and therapeutics
Authors: A. Hadis Mohammed , Shortall Adrian C. , M. Palin William
Published: March 2024

Harnessing the power of light and its photonic energy is a powerful tool in biomedical applications. Its use ranges from biomaterials processing and fabrication of polymers to diagnostics and therapeutics. Dental light curable materials have evolved over several decades and now offer very fast (≤ 10 s) and reliable polymerization through depth (4–6 mm thick). This has been achieved by developments on two fronts: (1) chemistries with more efficient light absorption characteristics (camphorquinone [CQ], ~30 L mol-1 cm1 [ʎmax 470 nm]; monoacylphosphine oxides [MAPO], ~800 L mol-1 cm-1 [ʎmax 385 nm]; bisacylphosphine oxide [BAPO], ~1,000 L mol-1 cm-1 [ʎmax 385 nm]) as well mechanistically efficient and prolonged radical generation processes during and after light irradiation, and; (2) introducing light curing technologies (light emitting diodes [LEDs] and less common lasers) with higher powers (≤ 2 W), better spectral range using multiple diodes (short: 390–405 nm; intermediate: 410–450 nm; and long: 450–480 nm), and better spatial power distribution (i.e. homogenous irradiance). However, adequate cure of materials falls short for several reasons, including improper selection of materials and lights, limitations in the chemistry of the materials, and limitations in delivering light through depth. Photonic energy has further applications in dentistry which include transillumination for diagnostics, and therapeutic applications that include photodynamic therapy, photobiomodulation, and photodisinfection. Light interactions with materials and biological tissues are complex and it is important to understand the advantages and limitations of these interactions for successful treatment outcomes. This article highlights the advent of photonic technologies in dentistry, its applications, the advantages and limitations, and possible future developments.
Mot nye identiteter i Sápmi?
Authors: Pedersen Inger
Published: March 2024

This chapter explores how today’s and perhaps future young people in Sápmi shape their Sami identity through narratives from seven young coastal Sámi in a coastal Sámi community. In the official definition from the Norwegian Sámi Parliament (Sámi Parliament, 2023), having a Sámi-speaking great-grandparent and identifying as Sámi oneself is sufficient to be considered Sámi and included as a voter. However, there are other definitions and approaches to being Sami, outside the public system, that have a severe impact on young people, for example on various websites, blogs and digital newspapers. The analysis in this chapter leans on anthropological and postcolonial theory, exploring how the participants position themselves to what they consider a Sámi ethnic identity in this complex social context.
PENERAPAN MODEL PEMBELAJARAN PROBLEM SOLVING TUTOR SEBAYA UNTUK PEMAHAMAN KONSEP SISWA MATERI HUKUM KIRCHHOFF
Authors: K.A. Astiti  , P. Maunino  , V. Lantik
Published: March 2024

Penerapan model pembelajaran yang kurang bervariasi menyebabkan pemahaman konsep siswa menurun. Penelitian ini bertujuan untuk mengetahui bagaimanakah model pembelajaran Problem Solving teknik tutor sebaya dapat meningkatkan kemampuan pemahaman konsep fisika siswa dalam materi Hukum Kirchhoff. Jenis penelitian yang di gunakan adalah Penelitian Tindakan Kelas (PTK), sampel penelitian adalah siswa kelas XI Mia 3 SMA Negeri 9 Kota Kupang sebanyak 25 orang siswa. Instrumen penelitian yang digunakan adalah soal tes berupa uraian. Data hasil ketuntasan pemahaman konsep dianalisis dengan menghitung data presentase tes pemahaman konsep fisika dan rata-rata ketuntasan klasikal. Data siklus I menunjukan presentase pemahaman konsep siswa adalah 76% dan ketuntasan klasikal yaitu 74% dengan kriteria belum tuntas. Siklus II menunjukan presentase pemahaman konsep mencapai 93% dan ketuntasan klasikal 100%  dengan kriteria tuntas. Maka, penerapan model pembelajaran Problem Solving teknik tutor sebaya dapat meningkatkan pemahaman konsep fisika siswa kelas XI Mia 3 SMA Negeri 9 Kota Kupang.
EFEKTIVITAS MODEL PEMBELAJARAN HERVINA TERHADAP KARAKTER DAN LITERASI SAINS SERTA RELEVANSINYA TERHADAP KURIKULUM MERDEKA SEKOLAH PENGGERAK
Authors: N.P.A.H. Sanjayanti  , N.W.S. Darmayanti
Published: March 2024

Tujuan penelitian ini adalah untuk mengetahui efektivitas model pembelajaran HERVINA terhadap karakter dan literasi sains, serta relevansinya terhadap kurikulum merdeka Sekolah Penggerak. Subjek pengujian efektivitas dilakukan pada siswa kelas VIII SMP Sekolah Penggerak di Kabupaten Buleleng yang jumlahnya sebanyak 158 siswa, yaitu di SMPN 1 Seririt sebanyak 58 siswa, SMPN 3 Singaraja sebanyak 50 siswa, dan SMPN 4 Sukasada sebanyak 50 siswa. Instrumen pengumpulan data karakter menggunakan kuesioner dan data literasi sains menggunakan tes literasi sains. Kedua instrumen tersebut telah memenuhi katagori valid dan reliabel. Metode analisis data untuk memperoleh hasil pengujian efektivitas dilakukan dengan analisis MANOVA dengan taraf signifikansi sebesar 5%. Hasil penelitian menunjukkan model pembelajaran HERVINA sangat efektif diterapkan pada sekolah penggerak dengan ES=1,86 terhadap  karakter F=435,32 (p<0,05)  dan literasi sains siswa F=57,50 (p<0,05).
EFEKTIVITAS PENGGUNAAN LEMBAR KERJA INTERAKTIF BERBASIS GEOGEBRA DALAM MENINGKATKAN EFIKASI DIRI MAHASISWA PADA MATA KULIAH FISIKA DASAR
Authors: I.G. Arjana
Published: March 2024

Efikasi diri merupakan salah satu faktor yang mempengaruhi keberhasilan peserta didik dalam mengikuti proses belajar di kelas, Penelitian ini bertujuan untuk mengetahui efektivitas penggunaan lembar kerja interaktif berbasis GeoGebra dalam meningkatkan efikasi diri mahasiswa pada mata kuliah fisika dasar. Efikasi diri yang dimaksud adalah keyakinan mahasiswa terhadap kemampuan dirinya dalam mencapai tujuan atau tugas tertentu yang dalam hal ini terfokus pada pemahaman konsep fisika yang dipelajari. Efikasi diri yang tinggi dapat meningkatkan motivasi dan kinerja mahasiswa dalam menyelesaikan tugas atau mencapai tujuan. Penelitian ini dilakukan menggunakan desain eksperimen one group pretest-posttest. Sampel penelitian terdiri dari mahasiswa semester dua yang mengambil mata kuliah fisika dasar. Efikasi diri mahasiswa diukur menggunakan skala efikasi diri mahasiswa sebelum dan setelah perlakuan pada 4 kategori utama yakni (a) keyakinan mengatasi kesulitan dalam memahami konsep fisika dasar, (b) keyakinan dalam berkontribusi pada sesi diskusi kelas tentang fisika dasar, (c) keyakinan dalam menghadapi ujian atau evaluasi fisika dasar, dan (d) keyakinan dalam mengatasi rintangan umum dalam belajar. Hasil penelitian menunjukkan bahwa terdapat perbedaan signifikan dalam efikasi diri mahasiswa sebelum dan sesudah menggunakan lembar kerja interaktif berbasis GeoGebra (t(39) = 4,319, p < 0,005). Penggunaan lembar kerja interaktif berbasis GeoGebra dapat dijadikan alternatif dalam meningkatkan efektivitas pembelajaran fisika dasar dan meningkatkan efikasi diri mahasiswa. Penelitian selanjutnya dapat memperluas cakupan dan melibatkan sampel yang lebih besar, serta memperdalam analisis efektivitas penggunaan lembar kerja interaktif berbasis GeoGebra pada pembelajaran fisika dasar.
The Role of Digital Technology Self-Efficacy and Digital Technostress on Intention to Use FinTech: A Study on MSMEs in Surakarta City
Authors: Putriani Santi , Sinta Putriana  , Khoirul Fuad  , Mega Wahyu Widawati  , Nur Prasetyo Aji
Published: March 2024

This research aims to investigate the role of Digital Technology Self Efficacy and Digital Technostress on the intention to use FinTech among Micro, Small, and Medium Enterprises (MSMEs) in Surakarta City. This research uses a questionnaire survey with the criteria for respondents being MSMEs in any field that provides FinTech options for transactions in the city of Surakarta. After obtaining a final sample of 138 MSMEs in Surakarta City, analysis was then carried out using SEM-PLS with the help of the Warp-PLS analysis tool. The research results show that even though all Technostress constructs such as overload, invasion, complexity, and uncertainty do not influence the intention to use FinTech among MSMEs in Surakarta City. However, Digital Technology Self-Efficacy can increase the intention to use FinTech among MSMEs in Surakarta City and can reduce the negative impact of the relationship between Digital Technostress and the intention to use FinTech among MSMEs in Surakarta City. The results of this research can be input for innovators and policymakers to make FinTech applications easier to use and inclusive so that MSMEs will continue to use FinTech and ultimately can participate in supporting sustainable development.
Keywords: FinTech, Technostress, Digital Technology Self Efficacy, MSMEs, Surakarta.