bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinico-Pathological Characteristics of Endometrial Carcinoma with Mismatch Repair Deficiency
Authors: Khatoon Dr. Farhana , Yasmin Dr. Lubna , Naher Dr. Syfun , Meher Dr. Subrina , Akther Dr. Moushume , Sayed Dr. Sunzia
Published: September 2024

Background: Endometrial carcinoma (EC) is a common gynecologic malignancy with significant implications for women's health. Mismatch repair deficiency (MMRd) has emerged as a critical factor influencing the pathogenesis and prognosis of EC. This study aims to investigate the clinicopathologic characteristics of MMRd EC in a Bangladeshi cohort. Methods: This cross-sectional observational study was conducted at the Department of Gynecological Oncology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from March 2022 to February 2023. A total of 49 patients with histologically confirmed EC were included. Data were collected through a semi-structured questionnaire and patient records. Results: Among the 49 patients, 67.35% (n=33) were MMR proficient, while 32.65% (n=16) were MMR deficient. The mean age was 55 years for MMR proficient and 55.6 years for MMR deficient patients. Hypertension was present in 69.70% of MMR proficient and 75% of MMR deficient patients, while diabetes mellitus affected 54.55% of MMR proficient and 62.50% of MMR deficient patients. MMRd patients showed higher rates of adnexal involvement (37.50% vs. 6.06%, p=0.010) and metastasis (37.50% vs. 9.09%, p=0.024). Multivariate logistic regression identified advanced FIGO stage (III & IV) as a significant predictor of MMR deficiency (adjusted OR 4.274, 95% CI: 1.691-15.515, p=0.025). Conclusion: MMRd in endometrial carcinoma is associated with more aggressive tumor features and poorer prognostic indicators. Routine evaluation of MMR status is crucial for effective prognosis and treatment planning. Addressing socioeconomic disparities and integrating targeted therapeutic strategies can improve management and outcomes for patients with MMRd endometrial carcinoma in diverse populations.
Traumatic Uterine Rupture by Public Road Accident in Young Pregnancy about a Case at the Fousseyni Daou Hospital in Kayes (Mali)
Authors: Ballan Malcalou , Mahamadou Diassana , Sitapha Dembele , Alima Sidibe , Lassina Goita , Samou Diarra , Z Dao Seydou, , Mamadou Haidara , Famakan Kane , Fantamady Camara
Published: September 2024

Uterine ruptures are common in Africa incidence 1 per 70 to 151 deliveries [1]. Rupture of the gravid uterus affects less than 1% of pregnant women involved in a public road accident. We report a case of uterine rupture due to direct abdominal trauma during a road accident (AVP) occurring in Kayes (Mali) [1].
Accidents with Lepidoptera (Insecta): Biology, Poisonous, Clinical Manifestations, Treatment, Prevention, and Therapeutic Possibilities
Authors: Marchiori Carlos Henrique , Santana Marco Vinícios de Oliveira , Malheiros Klebert de Paula
Published: September 2024

Accidents triggered by contact with winged adult forms of moths and accidents caused by contact with larvae. These accidents are caused by contact with the bristles on the abdomen of females of certain species, belonging to the genus Hylesia Hübner, 1820 (Family: Hemileucidae). Therefore, the simple fact of penetration of the bristles seems to be capable of causing intense inflammatory, popular, and pruritic reactions. Pararama (pararamose) is the common name for a stinging caterpillar found in the artificial rubber plantations of Pará, Brazil, the larval stage of the moth Premolis semirufa (Walker, 1856) (Famíly: Erebidae). Therefore, accidental contact with the small bristles of the caterpillars or with those of the cocoons causes a chronic inflammatory reaction in the interphalangeal joints that leads to ankylosis. The morbid condition mainly affects rubber tappers and is classified as an occupational disease. Eruca=larva; erucism is poisoning caused by a moth larva. The main families of Lepidoptera fireworms that cause erucism accidents are Megalopygidae, Saturniidae, and Arctiidae. The caterpillars of the Megalopygidae family have a body covered with long, harmless bristles that cover the smaller, sharp spines that carry poison glands this manuscript aims to report the biological characteristics of venomous Lepidoptera (Insecta) and their biological, clinical manifestations, treatment, prevention, and therapeutic possibilities. That paper is a narrative review of the literature, which is designed to explain and discuss a certain subject from a theoretical or contextual perspective, to allow the reader to acquire or update knowledge on a specific topic. The scientific articles that made up this review were searched on Google Scholar, Biological Abstract, HAL, Qeios, ResearchGate, Scielo, and SSRN. The following descriptors in Health Sciences (DeCS) were used: biological therapy, larva, wound, debridement, and healing. The following inclusion criteria were considered: original articles and reviews, published nationally and internationally in full, available electronically, and published in Portuguese, English, and Spanish. The exclusion criteria were dissertations, theses, monographs, and conclusion work, duplicates, and those that required payment to access the content in full.
Review Based Study of Monkeypox Disease: A Public Health Emergency of International Concern.
Authors: Balwan Wahied Khawar , Balwan Walied Khawar , Saba Neelam
Published: September 2024

Monkeypox, a zoonotic disease, has become the hot topic spreading across the newspaper headlines like a forest fire. The disease is transmitted from one individual to another by close, intimate contact such as cuddling, kissing, or contact with fluids in the dermal lesions. Though it is a self-limiting disease with symptoms akin to Smallpox (but a milder version), some severe cases have been reported as well. WHO has reported the case fatality rate of Monkeypox infection to be around 3–6%, which is slightly higher than that of COVID-19. Incubation period of the disease is 6–13 days on an average (range of 5–21 days). The monkeypox virus, which was previously exclusive to West and Central African nations and caused endemic diseases in monkeys and people, has recently been linked to human infections in non-endemic areas including the United States of America (USA) and more than 30 additional countries. The monkeypox outbreak continues to be a worldwide health emergency, the highest degree of alert recognised by the World Health Organization. The Centers for Disease Control and Prevention (CDC) advises vaccination for those who have been exposed to the disease as well as those who may be at higher risk of contracting it, such as those who have been identified by public health officials as a contact of someone who has the disease.
A Study on Serum Hepatic Enzymes in Smokers and Nonsmoker’s Adult Male
Authors: Afroz Dr. Mst. Arifa , Hasan Dr. Md Farucul , Rahman Dr. Md. Mostaqimur , Taz Dr. Kamruzzaman Abne , Khan Dr. Md. Abdus Sabur , Aziz Dr. M.A. , Khanam Dr. Tasnim , Haider Dr. Sharmin Binte
Published: September 2024

Background: Cigarette smoking is one of the greatest indirect causes of global death and disease. Cigarette smoke consists of many chemicals, including cytotoxic, carcinogenic and free radicals, therefore it affects many organs including liver either directly or indirectly. Objective: The aim of this study was to find out level of serum hepatic enzymes in smokers and non-smokers adult male. Method: This cross-sectional study was conducted in the Department of Biochemistry, Dhaka Medical College, Dhaka, Bangladesh, from January 2019 to December 2019. Total study subjects were one hundred and twenty with age ranging from 20 to 50 years of male gender, selected from attendance of admitted patients and third & forth class employees of Dhaka Medical College Hospital, Dhaka. Study subjects were grouped smokers as Group A and age and gender matched, nonsmokers as Group B. Group A smokers again divided into three groups. Group A1- heavy smokers (who consume 20 cigarette sticks or more per day) consist of thirty study subjects, Group A2- moderate smokers (who consume 11-19 cigarette sticks per day) consist of thirty study subjects and Group A3- light smokers (who consume 1-10 cigarette sticks per day) consist of thirty study subjects. Serum Alanine Transaminase (ALT), Aspartate transaminase (AST) and Alkaline phosphatase (ALP) level of all study subjects were estimated and recorded. Results: Mean age of the study subjects in group A1, A2, A3 & B were 33.88 years, 34.60 years, 34.60 years and 29.80 years. There was a significant increase in serum ALT, AST and ALP level in heavy, moderate and light smokers when compared to nonsmokers, but the increase was more significant in heavy smokers when compared to moderate smokers, also moderate smokers when compared to light smokers. Conclusion: This study revealed that significantly higher level of serum hepatic enzymes with smokers when compared to that of non smokers. This significantly higher level was also seen in heavy smokers in comparison to moderate smokers, moderate smokers in comparison to light smokers.
Characteristics and Demographic Features of Vitamin A Deficiency in Sudan during War, 2023-2024
Authors: Ibraheim Khalil Ali , Ahmed Hussain Gadelkarim
Published: September 2024

Background: A deficiency is a public health issue for many children and adults. In wartime hardship, patients eat little meat, dark vegetables, and fruits, which can cause vitamin A deficiency and corneal dryness, erosion, ulceration, and perforation. The purpose of this study was to identify the characteristics and demographics of vitamin A insufficiency in Sudan during the 2023-2024 war. Methodology: This prospective descriptive study was carried out between June 15, 2024, and August 15, 2024, at Dr. Khalil's Ophthalmology Center in North Kordofan, Sudan. The study looked at 100 individuals who presented at the clinic complaining of deficient night vision (including full coverage during the notification period). Results: In this study, only six patients had corneal opacity, with 67% being males and 33% females. In terms of Bitto's spots, 12% are present, with males and females having 58% and 42%, respectively, and 46% having dry eyes. 52% were males and 48% were females in terms of retinal pigmentation. Only one female patient exhibited peripheral retinal pigmentation, which was due to retinitis pigmentosa; all patients had inadequate food intake; and no diarrhea was reported. Conclusion: In Sudan, the rise in vitamin deficiency can be attributed to the inadequate development of all health system programs. Additionally, the devastating war, which primarily affects young people, has forced most people to leave their homes and become either displaced or refugees. Consequently, 69% of the patients were 17 years old or younger.
Comprehensive Survey on the Performance of Lignocaine in Root Canal Treatment
Authors: Shaikh Uzmaa , Thakre Kalyani , Jagtap Gayatri , Jadhav Bhagyashree , Kulkarni Dr. Vaidehi , Mookhtiar Dr. Hussain , Hegde Dr. Vivek
Published: September 2024

Objective: The study aimed to evaluate the efficacy of lignocaine as a local anesthetic in root canal treatment, particularly focusing on its use in lower teeth, different administration techniques, and its performance in patients with specific challenges such as inflammation or allergy. Methods: A survey-based approach was utilized to gather data from clinicians on their experiences with lignocaine in endodontic procedures. The study assessed the success rates of various techniques, including the inferior alveolar nerve block (IANB), intraligamentary, and intraosseous injections. The impact of different adrenaline ratios (1:100,000, 1:80,000, and 1:200,000) on anesthesia duration and effectiveness was also analyzed. Results: Lignocaine with 1:100,000 adrenaline was effective in the majority of cases, with IANB being the primary technique used for lower Lignocaine was identified as the anesthetic of choice by the majority of participants, preferred for its rapid onset and adequate duration of action. Most clinicians reported that lignocaine provided effective anesthesia for routine root canal procedures when inflammation was present or additional duration was required, clinicians recommended using supplemental techniques such as intraligamentary and intraosseous. Alternative anesthetics like articaine and bupivacaine were used successfully in patients with lignocaine allergies. Conclusion: Lignocaine remains a reliable anesthetic for root canal treatments, particularly in the lower jaw, when used with appropriate techniques and adrenaline ratios. However, challenges such as inflamed tissues and patient allergies require alternative strategies, including supplemental injection techniques and the use of different anesthetic agents. Clinicians should be adaptable in their approach to ensure effective anesthesia and patient safety. The study aimed to evaluate the efficacy of lignocaine as a local anesthetic in root canal treatment, particularly focusing on its use in lower teeth, different administration techniques, and its performance in patients with specific challenges such as inflammation or allergy.
Metabolit Bioaktif Bakteri: Tinjauan tentang Potensi Antimikroba dan Aplikasinya
Authors: Nova Bastian , Supri Wardi Epi , Sartika Diza
Published: September 2024

Bakteri merupakan sumber yang menjanjikan dari senyawa bioaktif. Dalam tinjauan ini, penelitian yang ada mengenai molekul antimikroba dari bakteri disajikan secara ringkas. Selain itu, tinjauan ini secara singkat merangkum bakteriosin, non-ribosomal peptida, poliketida, dan lipopeptida yang menargetkan patogen yang resisten terhadap beberapa obat dan mempertimbangkan antibiotik generasi berikutnya. Tinjauan ini menyoroti kemungkinan penggunaan bakteri sebagai sumber antimikroba untuk aplikasi bioteknologi, nutrasetik, dan farmasi. Namun, investigasi lebih lanjut diperlukan untuk mengisolasi, memisahkan, membersihkan, dan mengkarakterisasi senyawa bioaktif ini serta memformulasisenyawa aktif tersebut menjadi antibiotik yang disetujui secara klinis.
FEATURES OF WASHING WATER-SOLUBLE PHOSPHORUS-AMMONIUM SALTS OF FIREPROOF WOOD COATING
Authors: Цапко Ю. В. , Бондаренко О. П. , Цапко О. Ю. , Каверин К. О. , Семігран Д. Ю.
Published: September 2024

The article analyzes fire-resistant materials for wooden building structures and establishes the need to develop reliable methods of researching the process of washing out flame retardants from the surface of the building structure, which are necessary for the creation of new types of fire-resistant materials. Therefore, there is a need to determine the conditions for the formation of a barrier for leaching and to establish a mechanism for inhibiting the transfer of moisture to the material. In this regard, a mathematical model of flame retardant leaching has been developed, when a polymer shell made of organic material is used as a coating, which allows evaluating the effectiveness of the polymer shell based on the amount of flame retardant washed out. According to experimental data and theoretical dependences, the dynamics of release of flame retardants from the fire-resistant layer of the coating, which does not exceed 1.0%, is calculated, and accordingly provides fire protection of wood. The results of determining the loss of mass of the sample during exposure to water indicate an ambiguous effect of the nature of the protection on leaching. In particular, this assumes the availability of data sufficient for qualitatively carrying out the process of inhibiting moisture diffusion and identifying, on its basis, the moment in time when the decline in coating efficiency begins. Experimental studies have confirmed that a sample of fire-resistant wood after exposure to water for 30 days withstood the influence of heat flow. In particular, the loss of wood mass after temperature exposure was less than 6%, and the temperature of flue gases did not exceed 185 ºС. Thus, there are reasons to assert the possibility of targeted regulation of wood fire protection processes through the use of polymer coatings capable of forming a protective layer on the surface of the fire retardant material, which inhibits the rate of flame retardant leaching.
Flexible employment as a means of preserving jobs at ukrainian enterprises during the war
Authors:   Simon Kuznets Kharkiv National University of Economics, Achkasova Oksana
Published: September 2024

The article examines the relevance of flexible forms of employment in the context of current economic challenges, especially in connection with the war in Ukraine. Ensuring the effectiveness of flexible employment is critical for preserving jobs and maintaining the economic stability of enterprises in the current crisis conditions. The purpose of the study was to analyze approaches to the introduction of flexible employment at Ukrainian enterprises and recommendations for adapting the existing model of flexible employment to the conditions of martial law to preserve jobs at enterprises and ensure a balance between the economic interests of enterprises and social guarantees for employees considering the specifics of the modern labor market, and to develop. It has been proven that in times of crisis, flexible forms of employment become a vital tool for preserving jobs and maintaining economic stability, as well as increasing the adaptability of employees to changing labor market conditions, which is critical in times of crisis. However, existing flexible employment models need to be adapted to war conditions. The article develops recommendations for enterprises to introduce flexible forms of employment that allow them to maintain productivity and minimize social tension among employees. These recommendations include using remote work, part-time work, and digital platforms to attract freelancers, as well as measures to improve the social protection of employees, implement mental health support programs, and adapt labor contracts to the new conditions. The practical value of the study lies in the development of specific recommendations for enterprises that will allow them not only to maintain their functioning in the crisis but also to ensure sustainability and development in the long term. The proposed measures can be used as a basis for further improvement of HR management strategies in conditions of instability and crisis. Keywords: flexible employment, crisis model, social guarantees, remote work, outsourcing, outstaffing.
Generalized Extended $C$-Bochner Curvature Tensor on $(\grave{k},\grave{\mu})$-Contact Metric Manifolds
Authors: Yıldız Ahmet
Published: September 2024

The object of the present paper is to study $(\grave{k},\grave{\mu})$-contact metric manifolds with generalized extended $C$-Bochner curvature tensor.
MILITARY SURVEILLANCE BOT
Authors: Rao Chandra , Anusha G. , Manisha K. , Sahithi V. , Sathwika Y. Sai
Published: September 2024

This research describes a cutting-edge method for border and distant surveillance using multipurpose robots that are based on the most recent 3G technology used in defense and military applications. This autonomous vehicle has the capacity to conduct surveillance in border regions in place of soldiers. Using the internet as a communication tool, the robotic vehicle may be operated both manually and autonomously. This multimodal robot is employed in distant and combat zones to detect fire, explosives, hazardous gasses, and people. Traditional wireless security robots are rendered obsolete by their constrained human control and frequency range. The use of 3G technology, which has an infinite range, allows one to overcome these restrictions. By using solar panels, this system further improves the usage of renewable energy sources. Infrared and ultrasonic sensors are used to operate autonomously. The DTMF decoder controls the manual operation, and mobile phones are employed as video cameras by initiating 3G video calls and modifying the robot's course based on surrounding real-time information. The experimental findings of the solar panel's tilt angle selection and power consumption in both automated and manual modes are also shown in this study. Under certain conditions, this robotic vehicle may be used for both surveillance and reconnaissance.
CYBER-PHYSICAL CUSTOMER MANAGEMENT FOR INTERNET OF ROBOTIC THINGS-ENABLED BANKING
Authors: Reddy Dr. Y. Geetha , Shruthi L. , Niharika M. , Swaroopa P.
Published: September 2024

Across the globe, in-person banking continues to play a significant role in financial services. Robotic service personnel at hybrid bank offices may increase productivity while cutting expenses. Hybrid banking needs an effective autonomous Know-Your-Customer (KYC). This research proposes an automated system for interbank KYC in robot-based cyber-physical banking based on deep learning. To protect the customer's privacy, a deep biometric architecture was used to model their KYC and anonymize the visual data that was gathered. The blockchain network and the symmetric-asymmetric encryption-decryption module were used to transmit and validate the biometric data in a secure, decentralized manner. For the safe transmission and storage of in-person financial documents, a high-capacity fragile watermarking technique based on the integer-to-integer discrete wavelet transform combined with the Z6 and A6 lattice vector quantization is also suggested. A Pepper humanoid robot was used to simulate and evaluate the suggested framework for automated biometric-based bank check collecting of handwritten checks from clients following COVID-19 pandemic safety protocols. Using the suggested framework, the biometric data of bank clients—such as their fingerprint and name—is watermarked and integrated in the relevant bank papers. Compared to comparable algorithms, the findings demonstrate that the suggested security protection framework can integrate more biometric data in bank papers. Moreover, compared to other suggested algorithms, the protected bank document quality is 20% better. Additionally, the banks' privacy needs may be met by the hierarchical visual information transmission and storage module that obscures people's identities in films that are gathered by robots. All things considered, the suggested framework may provide a quick, easy, and affordable interbank solution for upcoming in-person banking while abiding by banking laws and security standards.
Analiza technologii On-Shore Power Supply
Authors: Kulaszewska Wiktoria , Kosiek Julia
Published: September 2024

OnShore Power Supply (OPS), czyli tzw. „zasilanie lądowe”, umożliwia statkom otrzymywanie energii elektrycznej z lokalnej sieci. Korzystając z tej alternatywy, zanieczyszczenie środowiska jest zmniejszone, ponieważ pokładowy generator diesla może zostać wyłączony. Technologia ta, jest wykorzystywana od wielu lat, lecz dopiero teraz zdobywa uznanie.

W artykule dokonano analizy OPS. W części teoretycznej przedstawiono czym jest ta technologia i jaka jest budowa urządzeń zasilania lądowego. W części badawczej wykorzystano studium przypadku oraz analizę SWOT, która pozwoliła na wyróżnienie mocnych i słabych stron opisywanej technologii.
Resilience and improvement strategies for critical infrastructure in Pardubice
Authors: Bellay Tomáš , Laš Martin
Published: September 2024

The work focuses on the question of resilience and improvements strategies for critical infrastructure in Pardubice.
A 5-year study of bloodstream infections caused by carbapenemase-producing Gram-negative bacilli in southern Spain
Authors: Cobo Fernando , Reguera-Márquez Juan Antonio , Marín-Rodríguez José Antonio , Martín-Pérez Francisco José , Pérez-Palacios Patricia , Recacha Esther , Navarro-Marí José María
Published: September 2024

Introduction. The aim of this study was to evaluate the microbiological epidemiology of carbapenemase-producing Gram-negative bacilli (CPGNB) isolated from blood during a 5-year period. Methods. A total of 80 isolates from 78 patients were finally included; fifty-five (70.5%) were men and the mean age was 60 years. Detection of carbapenemase production was performed by immunocromatography (IC) and polymerase chain reaction (PCR). Genotyping was carried-out by pulsedfield gel electrophoresis (PFGE) and multi-locus sequence typing (MLST), and characterization of carbapenemase-producing isolates was performed by whole genome sequencing (WGS). Results. The main microorganisms isolated were K. pneumoniae (29.4%), E. cloacae (28.2%), A. baumannii (17.9%) and P. aeruginosa (15.3%). Overall, the most common carbapenemase in Enterobacterales was OXA-48 group (57.7%). The most common carbapenemase in non-fermenting bacilli was OXA-23 (60.8%). The most common ST in K. pneumoniae producing OXA-48 types was ST45 and in E. cloacae ST114, while in E. cloacae producing VIM types was ST78. In OXA-23 types, the most common clone in A. baumannii was ST2, whereas in P. aeruginosa producing IMP types was ST253. Conclusions. There was an increase in cases recorded in the years of highest incidence and severity of the SARS-CoV-2 pandemic, with a significant number of cases in patients admitted to the ICU. All bacteremias caused by A. baumannii were caused by the same clone, and 12 of the 14 cases caused by A. baumannii were part of outbreaks in the ICU.
Class Litigation in Canada
Authors:   RANEPA, Sutormin Nikita A.
Published: September 2024

The article is dedicated to class actions and class litigation in Canada. Initially evolved from legislative sources of England and the USA, class litigation in Canada has received independent and original development. The profound reform in Ontario that took place in July 2020 made significant amendments to Class Proceedings Act, 1992, which reflect the latest achievements in the field of class litigation. The latest changes in this Act are analysed in the article. Moreover, the following questions are raised: certification and authorisation as class proceedings, necessary to confirm the group for class action, its multiplicity, necessary to form the class action, questions of preferability of group procedure (predominance and superiority) and native language in class litigation. Special point of research is question of costs in class litigation, which has peculiar features in Canadian class action law. They consist in refusal to compensate the judicial costs or in compensation by third-party investor company or by the state (state funds). These approaches offer a fresh look at the problem of compensation of judicial costs in class litigation. The experience of Canada can be used in certain boundaries in Russia.
CFD (Computational Fluid Dynamics) Simulation of Hydrodynamic Vortex Turbine Performance: Influence of Notch Angle Variation on Flow Patterns and Efficiency
Authors: Sukadana I Gusti Ketut , Made Suarda  , I Putu Widiarta  , Ishak Danus
Published: September 2024

Hydrodynamic vortex turbines (HVTs) offer a promising solution for harnessing renewable energy from low-head water sources. The inlet notch angle, a critical geometric parameter, significantly influences the flow patterns within the turbine basin and, consequently, its overall performance. This study investigates the impact of notch angle variation on HVT efficiency and flow characteristics using computational fluid dynamics (CFD) simulations. A 3D model of an HVT was developed and simulated using ANSYS Fluent. The notch angle was varied between 7° and 15° in 2° increments. The k-ω SST turbulence model was employed to capture the complex flow behavior. Velocity and pressure contours were analyzed to understand the flow patterns, while turbine performance metrics, including torque, power output, and efficiency, were computed. The results revealed a strong correlation between notch angle and turbine performance. Increasing the notch angle led to higher flow velocities in the turbine basin, resulting in enhanced vortex formation and increased energy extraction. Consequently, both power output and efficiency improved with larger notch angles. The optimal notch angle, balancing efficiency and practical considerations, was identified. This study demonstrates the critical role of notch angle in HVT design. CFD simulations provide valuable insights into the flow dynamics and performance optimization of these turbines. The findings contribute to the advancement of HVT technology for sustainable micro-hydro power generation.
Influence of Head Teachers’ Leadership Practices on Pupils’ Learning Outcomes in Public Primary Schools in Narok North Sub County, Kenya
Authors: Gichuhi Grace Wangari , Nyakundi Gilbert Morara , Onyango Martin Ouma
Published: September 2024

This study sought to investigate the influence of head teachers’ instructional leadership practices on pupils’ learning outcomes/expectations in public primary schools in Narok North Sub-County, Kenya. This was specifically addressed by seeking to establish the influence of instructional supervision and motivational strategies on pupils’ learning outcomes/expectations in public primary schools in Narok North Sub-County, Kenya. The study employed the descriptive survey design. The target population constituted 54 public primary schools in Narok North Sub-County presented by 54 headteachers and 100 grade 5 teachers. Random sampling design was used to sample 129 respondents (45 head teachers and 84 teachers) from the target population. The descriptive analysis was used to establish the perceived level of head teachers’ instructional supervision, motivational strategies and pupils’ learning outcomes. Multiple Linear regression analysis was used to establish the influence of head teachers’ instructional supervision, motivational strategies and resource provision on the pupils’ academic performance and if the influences explained was statistically significant. Multiple Linear regression analysis was used to establish the influence of head teachers’ instructional supervision and motivational strategies on the pupils’ academic performance and if the influences explained was statistically significant. The study revealed that headteachers’ instructional leadership practices consisted of classroom visitation, delegation of teaching duties, evaluation of records of work, holding conferences with teachers, lesson preparations and evaluation of pupils’ exercise books which considerably improved the learning outcomes of grade 5 Pupils in all the five subjects. Finally, the study recommended that Re-engineering workshops by the Ministry of Education should emphasize on curriculum instructional supervision leadership practices and learners’ motivational strategies with a view to improving the quality of Grade 5 Pupils’ learning outcomes in all the five subjects’ areas.
Harnessing the potential of ChatGPT in pharmacy management: a concise review
Authors: Noman Abdullah Al , Fahim MD Ismail Ahmed , Tonny Tamanna Shahrin , Samia Afroza Akter , Moinuddin Sakib M.
Published: September 2024

ChatGPT is one of the promising AI-based language models which has the potential to contribute to pharmacy settings in many aspects. This paper focuses on the possible aspects of pharmacy management where ChatGPT can contribute, the prevalence of its use in Saudi Arabia as a practical insight, case studies showing the potential of ChatGPT in answering health-related enquiries, its benefits, challenges, and future prospects of it. Helping clients, verifying medication, examining for potential reactions to drugs, identifying potential interaction between drugs, providing recommendation for suitable alternative medication therapies, assisting healthcare workers and supporting the search for novel medication are the biggest roles that are cited. The study highlights several benefits of using ChatGPT, including greater medical supervision, fewer drug errors, greater power over existing equipment, and support to study about the medicine sector. However, concerns about security, reliability, privacy, over-reliance on AI, and lack of natural judgement must be addressed by careful implementation under human review. The study also provided insight of practical application of ChatGPT in pharmacy education and possible ways of implementing ChatGPT in getting improved care and optimized operation. The future prospect of ChatGPT is promising but requires increased precision, integration of it into education programs, progressing of patient treatment and interaction, and facilitating novel research abilities. In general, the review suggests that ChatGPT has the potential to improve and modernize pharmacy processes but cautious implementation of this developing AI technology, combined with human knowledge is important to improve healthcare in the pharmaceutical field.
BIOLOGICAL AND ECOLOGICAL SIGNIFICANCE OF PREDATORY FISH
Authors:   Nukus State Pedagogical Institute Named After Ajiniyaz 2nd Year Student Of Biology Education, Uzbekistan, Joldasbaeva E.K.
Published: September 2024

The article contains information about specific characteristics of fish, predatory fish and their species.
ROLE OF THE GENE FOR XENOBIOTICS BIOTRANSFORMATION ENZYME IN TUMOR PROGRESSION IN ACUTE LEUKEMIA
Authors:   Master's Degree Tashkent International University Kimyo, Uzbekistan, Sabitova Z.A. , Ganijonov P.A. ,   Assistant At The Department Of Physiology, Fergana Medical Institute Of Public Health, Uzbekistan, Boboev K. T. ,   Doctor Of Medical Sciences., Professor Doctor Of Medical Sciences Professor Republican Specialized Hematology Scientific And Practical Hematology And Medical Center, Uzbekistan
Published: September 2024

Biotransformation enzyme genes play an important role in metabolism and processing of foreign substances (xenobiotics) in the body. Their role in tumor progression is their ability to modulate metabolic pathways by affecting the processing of xenobiotics, which may affect the development of tumors. This is a current topic of research in the field of oncology.
MORPHOLOGICAL STRUCTURE OF THE BRONCHIAL WALL WITHOUT LUNG PATHOLOGY IN ADULTS
Authors:   Samarkand State Medical University, Samarkand, Uzbekistan, Mardonovich Ismoilov Jasur , Aminovna Aminova Nigina ,   Samarkand State Medical University, Samarkand, Uzbekistan
Published: September 2024

The selection of this particular subject is motivated by the necessity to examine the cellular composition of the respiratory epithelium. Within the respiratory epithelium lies a sophisticated tissue network that plays a crucial role in safeguarding the mucous lining of the respiratory passage. Goblet cells and submucosal glands situated in the layers serve as the primary origins of mucus. The mucociliary transport system of the respiratory passage is established through the collaboration of mucociliary cilia and secretory components. Although information regarding the bronchial epithelial layer is scarce, research studies have delved into the microscopic configuration of this layer and the age-related attributes of its transport function.
PATHOMORPHOLOGICAL CHANGES IN THE BRONCHI AND LUNG PARANCHYMA IN RESPIRATORY DISTRESS SYNDROME DEPENDING ON THE GESTATION TIME IN NEWBORNS
Authors:   Phd Samarkand State Medical University, Uzbekistan, Mardonovich Ismoilov Jasur , Aminovna Aminova Nigina ,   Samarkand State Medical University, Uzbekistan
Published: September 2024

The aim of this study was to identify the type of pathomorphological alterations in the lung tissue and bronchial wall of neonates that, based on gestational age, died from different types of pneumopathy. The study uses materials from the corpses of 74 newborns who passed away from various forms of pneumopathy in the Samarkand region's perinatal center. The bodies of the newborns were autopsied and studied in the pathoanatomical department of the Samarkand regional multidisciplinary hospital. Based on the distinct nosological forms of pneumopathy in neonates and their respective periods of maturity, the following groups were identified from the material: 1) Primary lung atelectasis by gestation: 22–28 weeks, 29–31 weeks, and 32–37 weeks. 2) Hyaline membrane disease, contingent on infant survival. Third, pneumopathy with an edematous-hemorrhagic form of pathology, which is also dependent on the period of neonatal life. An autopsy examining the lungs of infants whose primary diagnosis was primary pulmonary atelectasis revealed macroscopically reduced volume, cyanotic, inactive lungs with pointed, flat edges that did not fill the pleural cavities to capacity. Conclusions: Thus, hyaline membrane disease and primary atelectasis are the predominant morphological forms of pneumopathy in premature newborns.
INVESTIGATING LINGUISTIC FEATURES OF SHORT NEWS ARTICLES: A SCIENTIFIC ANALYSIS
Authors:   Teacher, Translation Faculty, The Uzbek State World Languages University, Uzbekistan, Egamberdiyevna Batirova Khurshida
Published: September 2024

This study investigates the linguistic features of short news articles, aiming to identify patterns and trends in language use within this genre. Using a corpus-based approach, we analyze a diverse collection of short news pieces, focusing on lexical, syntactic, and discourse-level characteristics. Our findings shed light on the unique linguistic strategies employed in the concise communication of information in the news media.
ANALYSIS OF SOME EXCEPTIONS IN HOMONYMY AND HOMONYMIC MODELS IN UZBEK ELECTRONIC CORPUS MANAGER
Authors:   Lecturer, Tashkent medical academy, Uzbekistan, Alijonova Fayruza
Published: September 2024

This article discusses the analysis of some homonymous units that create problematic situations in the process of searching for homonyms and dividing them into tokens in the Uzbek electronic corpus manager, and the alternative models that can be developed for them. Addressing the following homonymy problems and developing models for software can help overcome homonymy-related shortcomings for computational linguistics, particularly corpus linguistics.
CORPORATE GOVERNANCE: ENHANCING TRANSPARENCY THROUGH CMA PRACTICES
Authors:   Associate Professor Graduate School of Business and Entrepreneurship under the Cabinet of Ministers of the Republic of Uzbekistan, Begmatovich Farmonov Begzod
Published: September 2024

In today's Globalization process, corporate transparency and accountability are becoming increasingly important as organizations are scrutinized by stakeholders, investors and the public. Transparency is the ability of a company to provide clear, accurate and timely information about its activities, practices, decisions and activities. Accountability includes responsibility for the results of these decisions. Both of these principles are important to corporate governance, allowing organizations to protect their reputation and build trust among shareholders.
ASSESSING THE DEPTH AND LIQUIDITY OF UZBEKISTAN'S CAPITAL MARKETS: EVALUATE THE CURRENT STATE OF UZBEKISTAN'S CAPITAL MARKETS IN TERMS OF DEPTH, LIQUIDITY, AND THE RANGE OF AVAILABLE FINANCIAL INSTRUMENTS
Authors:   A Student Of The Mt-93 Group At Tashkent State University Of Economics, Uzbekistan, Og’abek Jo’rayev
Published: September 2024

The assessment of the depth and liquidity of Uzbekistan's capital markets is a crucial aspect of understanding the country's economic landscape. As a critical component of any economy, the capital market plays a vital role in facilitating the flow of capital, providing financing opportunities, and promoting economic growth. In this article, we will delve into an in-depth analysis of Uzbekistan's capital markets, examining the current state of the market, identifying key challenges, and proposing recommendations for improvement.
INNOVATIVE TYPE OF USE OF INVESTMENTS
Authors:   Assistant professor, Tashkent University of Architecture and Civil Engineering, Uzbekistan, Мukxibova G.Ya. , Sharifxodjaeva О.U. ,   Assistant, Tashkent University of Architecture and Civil Engineering, Uzbekistan
Published: September 2024

The innovative type of use of investments is a direction in which investments are directed to stimulate and support innovation. This includes funding scientific research, developing new products, technologies and processes, supporting start-ups and entrepreneurship, modernizing enterprise technology bases, education and training, and creating innovation infrastructure and ecosystems. Innovative investments play an important role in stimulating economic growth, improving the competitiveness of companies and creating new jobs, contributing to the development of new technologies and solving complex problems.
CUTE CHOLECYSTITIS MANAGEMENT: AI-DRIVEN SURGICAL DECISION-MAKING AND OUTCOMES
Authors:   Student Of The 5th Course Of Pediatric Faculty Andijan State Medical Institute, Uzbekistan, Qizi Akhmadbekova Iroda Anvarbek , Zukhriddinovich Salakhiddinov Kamoliddin ,   Scientific Leader: Dr. Professor, Vice Rector On Scientific Affairs Andijan State Medical Institute, Uzbekistan
Published: September 2024

This article provides important information on the adoption and results of artificial intelligence-based surgical decisions in the treatment of acute cholecystitis.
OUR EXPERIENCE IN THE TREATMENT OF HERPETIC KERATITIS IN CHILDREN
Authors:   City Clinical Children's Hospital No. 1 of the Ministry of healthcare of the Republic of Uzbekistan, Tashkent, Uzbekistan, M.M. Tabibova
Published: September 2024

According to WHO, diseases caused by the herpes simplex virus occupy the second place after influenza [1,4,5]. It has been established that up to 80% of cases of temporary disability are associated with inflammatory eye diseases, 50-60 of them% they receive inpatient treatment. According to various authors, a significant place among the causes of blindness or visual impairment (10-30% of cases) belongs to keratitis and keratouveitis. Most often, this corneal disease is caused by the herpes simplex virus, which are noted in 20-57% of cases among in the adult population and in 70-80% of cases - among children [3|. But at the same time, some authors report that herpetic primary infection is usually found in young children, but in a cold form and does not require treatment. In this regard, we decided to share our experience in the treatment of herpetic keratitis in children.
THIN ENDOMETRIUM: WHAT YOU NEED TO KNOW
Authors:   Assistant Samarkand State Medical University, Samarkand, Uzbekistan, Zafarjanovna Kurbaniyazova Feruza
Published: September 2024

Thin endometrium, a condition characterized by an abnormally thin uterine lining, can pose significant challenges to a woman's reproductive health, particularly in achieving pregnancy. This article delves into the intricacies of thin endometrium, encompassing its prevalence, associated problems, underlying causes, risk factors, diagnostic methods, and treatment options.
GOVERNMENT DEBT AND CRYPTOCURRENCIES: HOW BITCOIN IS CHANGING THE RULES OF THE GAME
Authors:   Acting Associate Professor of the Department of Banking, Banking and Finance Academy of the Republic of Uzbekistan, Salaev Rasul
Published: September 2024

In recent years, there has been a significant increase in public debt in many countries, which calls into question the sustainability of traditional financial systems. In this context, cryptocurrencies, especially bitcoin, are beginning to play an increasingly important role in the economy. This article explores the relationship between government debt and cryptocurrencies, focusing on how bitcoin can change the rules of the game in the financial world. We consider the mechanisms by which bitcoin and other cryptocurrencies can serve as an alternative to traditional financial instruments, as well as their potential as a means of protection against inflation and devaluation. In addition, the risks and benefits of investing in cryptocurrencies are analyzed against the background of growing government debt. The article also discusses the impact of regulation and government control on the development of the crypto market and its interaction with public finances. In conclusion, we hypothesize about the future role of bitcoin in the global economy and its ability to change the approach to public debt management.
STATE DEBT MANAGEMENT POLICY IMPROVEMENT PROSPECTS
Authors:   Professor of the Department of ", Nematullaevich Khamdamov Omonullo ,   Corporate Finance and Securities",   , Doctor of Economics, Tashkent State University of Economics, Uzbekistan
Published: September 2024

This article describes the economic importance and necessity of public debt in developing the national economy. The scientific approaches of economists to the effective management of state internal and debt have been researched and conclusions have been drawn. In recent years, the trends of changes in public debt in the Republic of Uzbekistan have been analyzed. Findings on the implementation of the public debt management strategy and its main directions are based. A scientific proposal and practical recommendations on improving the mechanism of efficient management and distribution of state debts have been developed.
Bir Derleme: Okul Örgütlerinde Güçlenme Temelli Okul Sosyal Hizmeti
Authors: İçer İkbal
Published: September 2024

Okul örgütlerinde güçlenme temelli okul sosyal hizmeti uygulamaları, okul örgütlerinde güç türleri, güç uygulamaları, güç dinamikleri, güç oyunları ve bununla mücadele biçimlerini içeren baskıyı kavramayı ve analiz etmeyi, güç ve baskıya odaklı güçlenme sürecini deneyimlemeyi içerir. İlgili alan yazında güçlenme temelli okul sosyal hizmeti uygulamalarında güç ilişkilerinin analizinin nasıl yapılacağına yönelik tartışmalara pek az yer verildiği, daha çok gücün sadece kavramsal boyutlarının ele alındığı gözlemlenmiştir. Okul örgütlerinde güçlenme temelli okul sosyal hizmeti konulu bu makalede, okul sosyal hizmeti uygulamalarında güçlenme yaklaşımının nasıl ele alındığı derlenmeye çalışılmıştır. Örgütsel bir güç olan okul ortamlarında güçlenme temelli okul sosyal hizmeti uygulaması, çeşitli baskılar nedeniyle güçsüzleştirilen öğrenci, veli, öğretmen, okul idaresinin deneyimlerini çok boyutlu değerlendirebilmeyi, sahip olduğu sorunların kaynağını baskı deneyimlerinde aramayı amaçlar. Bu amaç olumlu okul iklimi oluşturmada kendi sözlerini söyleyebilen ve kendi yaşamları üzerindeki kontrolü ele aldıkları yaşam politikalarıyla birlikte yeni bir okul politikası inşasında kritiktir.
To the epistemology of the concepts “information”, “data” and “knowledge”: legal and regulatory aspect
Authors: BRYZHKO V.
Published: September 2024

About the assessment of some rational views on the understanding and interpretation of the concepts “information”, “data” and “knowledge” and their application in law-making in connection, in particular, with the development of the electronic and communication environment. It was determined that human nature contains both a rational and an intuitive principle.
Legal approaches in the Artificial Intelligence Act: implications for Ukrain
Authors: DUBNIAK M.
Published: September 2024

This article draws attention to the key features of the Laying down harmonised rules on Artificial Intelligence in the EU (Artificial Intelligence Act, AIA). The author analyzes the concept of “Artificial Intelligence Systems” and the approach to determining the risky areas of AI application and other features of the AIA. Promising directions for improving the Ukrainian legislation on artificial intelligence are being formed, in particular, in terms of the data ecosystem and their legal use in artificial intelligence systems.