bluuebunny/crossref_metadata_2025 huggingface dataset:
The Pathway to Academic Performance: The Role of Motivation, Competence and Socio-familial Risk Factors in Lebanese Medical Students
Authors: Chatila Rajaa , Sr Jordan , Dimassi Hani , Faour Wissam , Khoury Jamil El , Bahous Sola , Choukair Mary , Nasser Ali , Nabi Sarah Abdul , Sanchez-Ruiz Maria-Jose
Published: June 2023

While cognitive abilities are known to have a certain degree of predictive value for academic performance, it is now well-established that motivation and emotion-related variables, along with environmental variables such as socio-economic status and family support, also significantly contribute to the academic success of university students. However, the specific mechanisms through which the environment influences these non-cognitive variables in predicting academic performance, particularly within the context of non-individualistic cultures, remain underexplored. In this study we examined the influence of family support, trait Emotional Intelligence (trait EI), and academic self-efficacy (ASE) on Academic Performance (AP). Additionally, we studied competence and motivation as potential mediators in the relationship between trait EI and academic self-efficacy (ASE). The study utilized structural equation models applied to two sub-samples drawn from a group of medical students. The first sub-sample, labeled the “low risk” group, consisted of students who reported minimal difficulty in paying bills and had highly educated parents. The second sub-sample, labeled the “high risk” group, included students who reported difficulty in paying bills and had less educated parents. The findings revealed that intrinsic motivation plays a more prominent role than extrinsic motivation as a mediator between trait EI, predicted by family support, and ASE, which in turn predicted AP. Among the low-risk students, both competence and intrinsic motivation fully mediated this relationship, whereas among the high-risk students, only competence acted as a mediator. These findings have significant implications for medical educational settings and are thoroughly discussed in this study.
On disturbed Fibonacci sequences
Authors: Paokanta Siriluk , Kim Hee Sik , Park Choonkil , Donganont Mana
Published: June 2023

In this paper, we introduce the notion of a disturbed Fibonacci sequence and obtain several properties related to Fibonacci sequences and apply the notion to Fibonacci rabbit farm to adjust the numbers of Fibonacci rabbits.
AMS Subject Classification: Primary; 11B39, 39A05; secondary 39A22
Oridonin alleviates lipopolysaccharide-induced acute lung injury in mice through inhibiting apoptosis, oxidative stress, and inflammation by modulating VIP/cAMP/PKA/AQPs signaling pathway
Authors: Liu Qinghua , Shang Wenli , Zhang Junli , Chen Ran , Wei Li , Wang HaiDong , Zhang Min , Yue Maokui
Published: June 2023

Oridonin (ORI) are a traditional Chinese herbal medicine extracted from Isodon rubescens (Hemsl.) H.Ha. There are few studies on the protective effect of ORI ameliorates acute lung injury (ALI) in mice. This result showed that compared with the ALI group, ORI significantly reduced the total protein content, Wet-to-dry (W/D) ratio, the number of neutrophils, lymphocytes, and monocytes. Moreover, ORI was able to reduce cell apoptosis, the levels of Macrophage inflammatory protein-2 (MIP-2), Intercellular adhesion molecule-1 (ICAM-1), Tumor necrosis factor-α (TNF-α), Malondialdehyde (MDA) and Myeloperoxidase (MPO) and increase the level of Superoxide (SOD). In addition, ORI could up-regulate the levels of VIP, cAMP, p-PKA/PKA and AQP1. In conclusion, our findings indicate that ORI can modulate the inflammatory injury of lung tissue caused by LPS through the VIP/cAMP/PKA/AQPs signaling pathway, suggesting that ORI can be a candidate for the therapeutic or preventive intervention in acute lung inflammation.
Role Toll-like receptor 4 gene underlying Hypoxia-inducible transcription factor 1α gene expression in cervical cancer of women
Authors: Nama Mustafa Adnan , Kraidi Qayssar Ali
Published: June 2023

Molecular methods are being used in cervical cancer screening to identify high-risk human papillomavirus. Annually, 490,000 new infections are diagnosed with papillomavirus, and about 298,000 death cases due to cervical cancer worldwide. Pap and biopsy samples from 65 samples from cervixes were collected from women with histological changes from Alsider Teaching Hospital, Maysan Hospital for Children, South of Iraq. The viruses were detected by RT-PCR in 69.2 % of the all cases. Extracted RNA samples were used to analyze the gene expression of Toll-like receptor 4 and hypoxia-inducible transcription factor 1α from biopsy samples. It was found that the number of positive samples for viruse genotype 16 was in 30 samples, which represents 66.6 %, while the genotype 18 was detected in 17 samples, which represents 37.7%, while 9 samples gave positive results for genotype 31 and represented about 20 %, relying on E6 or E7 specific primers in cDNA template by real-time PCR ,and the values of Toll-like receptor 4 in negative samples were normalized to the housekeeping gene (β actin) to 1 and its values in positive samples were compared to that 1 which was more roughly in 1-fold, and the hypoxia-inducible transcription factor 1α gene expression in positive samples was more in roughly 48-fold compared to its value in the housekeeping gene (β actin) to 1 (negative control). The study concluded that toll-like receptor 4 and hypoxia-inducible transcription factor 1α are overexpressed in cervical cancer, and both synergistically promote the development of cervical cancer.
Changing trends in the clinical profile of childhood in tuberculosis patients -at a tertiary centre
Authors: Yeredla Vishnu Vardhan Reddy , Tammali Saritha , Ravula Chaitanya Jyothi , Kalivela Santhimayee
Published: June 2023

The aim: To study the clinical profile of childhood tuberculosis in the age group of 6 months to 12 years.

Materials and methods: This сross-sectional study was conducted on patients of tuberculosis who were admitted for treatment. A total of 75 patients were enrolled in the study who are of age group: 6 months to 12 years and Stengen score>3.

Results: Approximately 50 % of the study population was under 5 years. 39 % belonged to the age group of 8–12 years. The male-to-female ratio was 1:1.02. 36 % of the study population belonged to the lower class. 33.33 % of the study population belonged to the middle class. One-quarter of the patients were not malnourished. Among the ones who were malnourished, 36 % belonged to Grade I, and 53.33 % had a Stengen score of 5–6. 46.66 % had a Stengen score of 46.66 %. Acid Fast Bacilli in 1.33 %, 18.66 % had tubercle present, 82.66 % had Mantoux positive, which was >10mm, and 62.66 % of them had suggestive radiology of tuberculosis, where the fever was present in 90 % of the study population. Fever with <2 weeks duration was present in 52 %, and the rest had a fever for more than two weeks. Cough was present in 77 % of the study population. Weight loss was present in 37.33 %. 22.66 % had pulmonary tuberculosis, and 77.33 % had extrapulmonary tuberculosis. Among extrapulmonary tuberculosis, lymphadenopathy was the common manifestation. It was present among 40 % of the study population. It includes cervical lymphadenopathy among 24 %, axillary lymph node involvement among 12 %, Sub mandibular lymph node among 2.66 % and supra clavicular in 1.33 %. The other manifestations of extrapulmonary tuberculosis include pleural effusion, the second most common one present among 29.33 % of the study population.

Conclusion: There is an urgent need for a systematic approach to determining the prevalence and incidence of M. tuberculosis infection among children. This has to become the cornerstone of TB control and of assessing the change in the trend of infection over time in the community until it reaches the required goal
Writing While Black: The Power of Words and Student’s Self-Empowerment
Authors: Wright Fields Christina A , Power-Carter Stephanie
Published: June 2023

Using the writings of a group of eleventh-grade African-American youths in a pre-college program, we illustrate what happens when youth are afforded opportunities to declare “their truth.” Facilitating such opportunities creates safe spaces to better hear often silenced and marginalized voices and provides chances to affirm and legitimize their experiences.
Do You See Us?
Authors: Walker Nina , Michener Catherine , Ieva Kara
Published: June 2023

This paper examines the literature on domestic minor sex trafficking. We draw on a critical race feminist lens, with particular attention to intersectionality and assemblage, to review research on conditions that exacerbate and decrease girls’ vulnerability to sex trafficking to emphasize why schools must systematically engage in sex trafficking prevention. We argue that school communities are positioned to address the intersectional and exacerbating conditions that make students, particularly Black girls, more vulnerable to this form of modern-day slavery. Rather than reinforce narratives that often criminalize and devalue survivors, the purpose of this article is to create a dialogue about how schools can be intentional in fighting sex trafficking in their communities. We provide specific recommendations for schools to place girls’ voices at the center of this prevention work and build knowledge within the school faculty to sustain this work, work that is both feminist and anti-racist, to equip students to become competent, confident, and empowered leaders.
Diverse Congregations, Similar Experiences: How Pastors of Different Ethnic and Racial Churches Encountered Similar Issues and Opportunities During the COVID-19 Pandemic
Authors: Campbell Heidi A. , Osteen Sophia , Sparks Grayson
Published: June 2023

It might be assumed churches coming from diverse cultural backgrounds would also express notable differences in how they conceptualize, operate, and envision the role of church, especially during times of crisis. However, despite having differing access to resources and levels of technological preparedness, this study found that congregations from diverse racial and ethnic backgrounds in Indiana responded surprisingly similar to the digital shift that was required of their congregations during the Covid-19 pandemic. In our study of Indiana churches use of technology during the pandemic, we found White, African American and Multicultural congregations all approached digital technology as an essential “tool” to be used to solve the problem of sustaining weekly gatherings. The only notable difference was a slight shift between 2020 to 2021 in African American congregations manifested in their perceptions of technology. These congregations began the pandemic conceptualizing technology as a simple tool to help them replicate in-person gatherings, but a year later they primarily saw technology as an innovative way to build new community connections. Interestingly, a similar shift in perspective was not noted amongst White congregations.
Arrested development and fragmentation in strongly-interacting Floquet systems
Authors: Wampler Matthew , Klich Israel
Published: June 2023

We explore how interactions can facilitate classical like dynamics in models with sequentially activated hopping. Specifically, we add local and short range interaction terms to the Hamiltonian and ask for conditions ensuring the evolution acts as a permutation on initial local number Fock states. We show that at certain values of hopping and interactions, determined by a set of Diophantine equations, such evolution can be realized. When only a subset of the Diophantine equations is satisfied the Hilbert space can be fragmented into frozen states, states obeying cellular automata like evolution, and subspaces where evolution mixes Fock states and is associated with eigenstates exhibiting high entanglement entropy and level repulsion.
Dynamic Relationship of Macro Variables and Liquefied Petroleum Gas Subsidy Transformation Program
Authors: Prabowo Eddy , Harianto Harianto , Juanda Bambang , Indrawan Dikky
Published: June 2023

Most Indonesians rely on liquefied petroleum gas as one of their primary sources of energy. Liquefied petroleum gas is classified into subsidized and non-subsidized. Subsidized liquefied petroleum gas is primarily used by low-income households, small businesses, and poor fishermen and farmers for cooking. However, no exit strategy has been established to overcome the increase in government spending on subsidized kerosene introduced in 2008. The problem is that macro variables may influence liquefied petroleum gas economic prices. The research aimed to identify the relationship between macro variables that might affect liquefied petroleum gas economic prices. It applied a quantitative method with Vector Auto Regression (VAR) and Vector Error Correction Model (VECM). The results demonstrate that inflation rate have a significant impact on the economic price of liquefied petroleum gas. Then, gross domestic product, inflation rate, and world gas price have positive correlations to the economic prices in liquefied petroleum gas. Meanwhile, currency exchange and world oil price have negative coefficients. The regression model indicates that a rise in inflation increases market prices in liquefied petroleum gas. Furthermore, the increased subsidized fuel means more poor people cannot afford liquefied petroleum gas. It is because high inflation reduces purchasing and potentially increases the number of poor people.
Improve Learning Programming through Small Private Online Course and Virtual IDE
Authors: Zulfikar Muhammad Taufiq
Published: June 2023

In learning programming languages ​​there are some technical problems such as the difficulty of installing IDE applications and tend to be heavy, cannot be used on various operating system platforms and there are no programming tutorials. By providing online and open learning content for certain organizations or often called SPOC (Small Private Online Course) and Virtual IDE to support SPOC, it can help students to improve programming skills. The purpose of this research is to create a SPOC LMS that has a Virtual IDE as a learning support. The Quantitative Method was used as a research method in this study to make a conclusion from the experimental results. The results of this study concluded that LMS SPOC and Virtual IDE can help students understand language programming.
A inclusão no ensino superior: O que revelam as narrativas de estudantes com deficiência física
Authors: Sousa Neide Maria Fernandes Rodrigues , Lima Danivea Cardoso
Published: June 2023

A pesquisa tem por objetivo compreender a percepção do estudante universitário com deficiência física sobre aspectos da inclusão educacional no seu processo formativo. O estudo de abordagem qualitativa ocorreu em um campus de uma universidade pública com acadêmicos com deficiência física. O levantamento aconteceu por meio de entrevista semiestruturada e questionário socioeconômico. Os dados foram tratados com base na análise de conteúdo. Os resultados foram discutidos considerando os eixos temáticos: o acesso e as políticas de inclusão; o ensino-aprendizagem e o processo formativo; as relações sociais e a acessibilidade arquitetônica. Os dados indicam que os participantes não utilizaram o sistema de cotas para acesso à instituição e que, para eles, a política inclusiva ainda é deficitária. Além disso, eles apresentam dificuldades na aprendizagem, identificam pouca flexibilização curricular, bem como, percebem pouca acessibilidade arquitetônica, sentindo barreiras atitudinais no que se refere às interações com alunos não deficientes. Conclui-se que a inclusão de estudantes com deficiência física no campus em questão é um processo em construção, pois há necessidade de avanços nos programas que propiciam a inclusão educacional para, então, possibilitar o pleno exercício dos direitos das pessoas com deficiência (PCDs) e contribuir para um processo formativo com qualidade.
O ensino de geografia da saúde: Uma forma de pensar a dinâmica do território para promover a saúde nas escolas
Authors: Garcia Miguel Pocharski , Kaercher Nestor André
Published: June 2023

Este estudo objetiva evidenciar a importância das práticas de ensino de Geografia da Saúde nas escolas. Para isso, realizamos uma análise documental, onde o principal material utilizado foi o Caderno de Saúde e Educação Ambiental, vinculado ao Programa Saúde na Escola, que propõem uma visão sistêmica entre os Determinantes Sociais da Saúde e o território. Com base nisso, formulamos práticas de ensino de Geografia da Saúde para que possam ser utilizadas pelos professores/as em suas aulas, bem como, uma proposta de trabalho de campo que visa a aproximação dos alunos ao território utilizado, com o intuito de promover a conscientização acerca dos problemas de saúde e incentivar a autonomia, para que eles atuem na busca por espaços mais saudáveis. Por meio disso, entendemos que o ensino de Geografia da Saúde apresenta um grande potencial para a promoção da saúde nas escolas, por ensinar os alunos a agirem de forma preventiva sobre os Determinantes Sociais da Saúde, melhorando o cuidado pessoal e coletivo, diminuindo, dessa forma, o risco de propagação de doenças e melhorando os níveis de bem-estar da população.
Efficacy of Picibanil Sclerotherapy in Treatment of Plunging Ranula
Authors: Jung Hyun Taek , Lee Sangmok , Nam Yunbin , Oh Jang Won , Shin Hyang-Ae , Kim Ji-Hoon
Published: June 2023

A plunging ranula is a pseudocyst caused by mucus secreted from the sublingual glands, and it is mainly observed on the mouth floor. Nowadays, sclerotherapy using picibanil has been performed instead of invasive surgical treatment, and studies are reporting safe and effective outcomes. In our study, more than 92% of the 25 patients had marked response after picibanil sclerotherapy, and no serious complications were observed. Picibanil sclerotheraphy can be considered as the primary treatment of plunging ranula for patients who refuse surgery under general anaesthesia.
A Large Intermuscular Lipoma of the Posterolateral Neck: A Case Report
Authors: Lee Kyung Suk , Shin Jae Bong , Kim Jun Sik , Do Gi Cheol , Kim Min Hyung , Kim Nam Gyun
Published: June 2023

Lipomas are a common soft-tissue tumor of mesenchymal origin, but intermuscular lipomas are very infrequently found especially in the cervical region. Although lipoma itself rarely causes complications, an accurate diagnosis and appropriate treatment are important. Surgical excision is indicated for deep lipomas that are 5 cm or larger, grow, or are accompanied by symptoms such as pain. It is also important to differentiate malignant tumors through pathological examination. Since the size of the lipoma was large, lipoma was divided into several pieces to successful removal, and the patient in this case showed successful recovery after surgery.
Talaş Kaldırma İşleminde Sürtünme Katsayısının Kesme Kuvvetleri, Sıcaklık ve Kesici Takım Gerilmeleri Üzerine Etkisi
Authors: SEKMEN Mustafa , KURT Abdullah , ŞEKER Ulvi
Published: June 2023

Bu çalışmada, endüstride büyük önem taşıyan tornalama işleminde kullanılan kesici takımların kesme performansının iyileştirilmesi amaçlanmıştır. Karbür kesici takımlarla AISI 1050 çeliği üzerinde farklı kesme parametreleriyle deneyler yapılmış ve dinamometre yardımıyla kesme kuvvetleri ölçülmüştür. Kesme parametreleri referans alınarak Deform-3D ile simülasyonlar yapılmıştır. Farklı sürtünme katsayılarıyla (0.3-0.4-0.5-0.6-0.7) yapılan simülasyonlardan elde edilen kesme kuvvetleri ile deneysel sonuçlar karşılaştırılmıştır. Ayrıca sürtünme katsayısının sıcaklık ve kesici takım gerilmeleri üzerindeki etkileri incelenmiştir. 0.4 ve 0.5 sürtünme katsayıları için simülasyon ve deneysel kesme kuvveti sonuçlarının birbirine yakın olduğu görülmüştür. Analizler sonucunda sürtünmenin kesici takım gerilmeleri ve sıcaklık üzerinde çok etkili olduğu gözlenmiştir. Sıcaklığa ve gerilmelere bağlı olarak kesici takımda oluşabilecek aşınma ve hasar noktaları belirlenmiştir. Çalışmadan elde edilen sonuçlar, kesici takım kesme performansının iyileştirilmesine ve optimum kesme parametrelerinin seçiminde önemli katkılar sağlayacaktır.
Türk İşaret Dilinin Sınıflandırılması için Derin Öğrenme Yaklaşımları
Authors: PACAL Ishak , ALAFTEKİN Melek
Published: June 2023

İşaret dili, sağır ve dilsiz bireylerin duygularını, düşüncelerini ve sosyal kimliklerini çevrelerine aktarabilmek için kullandıkları sözsüz bir iletişim aracıdır. İşaret dili, sağır ve dilsiz bireyler ile toplumun geri kalan bireyleri arasındaki iletişimde kilit bir role sahiptir. Normal insanlar arasında işaret dilinin çok yaygın bilinmemesi ve insan-bilgisayar etkileşiminin artmasıyla birlikte birçok işaret dili tanıma sistemleri geliştirilmiştir. Bu çalışmada, Türk işaret dili için literatürde ilk kez rakam temelli yeni bir veri seti önerilmiştir. Türk işaret dilinin otonom bir şekilde sınıflandırılması ve bu konuda sıkıntı yaşayan insanların iletişimini bilgisayar temelli yapabilmesi için en güncel derin öğrenme yaklaşımları önerilen veri setine uygulanmıştır. Çalışmada özellikle CNN tabanlı VGG, ResNet, MobileNet, DenseNet ve EfficientNet gibi en güncel ve popüler mimariler kullanılmıştır. Deneysel çalışmalarda ResNet152 modeli, %98.76 doğruluk, %98.85 kesinlik, %98.81 duyarlılık ve %98.80 F1-skoru ile diğer modellere göre daha iyi performans gösterdiği gözlemlenmiştir. Ayrıca, deneysel çalışmalarda kullanılan diğer modellerin hepsi %90'ın üzerinde bir başarım oranı göstererek önerilen veri setinin etkililiğini desteklemektedir. Bu, CNN modellerinin Türk işaret dilini tanımayı başarılı bir şekilde tespit yapabildiğini göstermektedir.
Atributos intangibles en alcatraz blanco (Zantedeschia aethiopica (L) K. Spreng): significados psicológicos y estructura de valores humanos para el consumidor
Authors: Cuéllar Mandujano Ana Karen , Hernández Montes Arturo , Cruz Castillo Juan Guillermo
Published: June 2023

Los productos poseen atributos tangibles e intangibles que influyen en las decisiones de consumo. En una encuesta, consumidores eligieron los 13 valores humanos más importantes y los 13 menos importantes, de una lista de 40. Calificaron la importancia de seis atributos tangibles del alcatraz y manifestaron la frecuencia de consumo de la flor. El análisis de escalamiento multidimensional se utilizó para identificar la estructura de valores humanos en consumidores. Los valores y los atributos tangibles fueron reducidos mediante análisis factorial. Se obtuvieron tres coeficientes de correlación: a) atributos tangibles y consumo; b) valores humanos y residuales de atributos tangibles, y consumo, y c) valores humanos y consumo. Se mostró una imagen de alcatraz a consumidores y se solicitó que mencionaran tres palabras que vinieran a su mente. Se aplicó la prueba de k de proporciones y el procedimiento de Marascuilo para las categorías de palabras afines. La influencia de valores humanos se dio principalmente por ruta directa, evidenciando la existencia de atributos intangibles, además de los tangibles, que influyen en decisión de consumo. El alcatraz posee mayor cantidad de significados psicológicos simbólicos (81.3 %), que utilitarios (18.7 %). La función psicológica simbólica incluye aspectos sensoriales, emocionales y afectivos. Los resultados podrían variar dentro de otros contextos culturales/regionales y con otras herramientas de investigación.
Propagation of SARS-CoV-2 in Cuba. A qualitative viewpoint from the complex systems theory
Authors: Sotolongo Costa Óscar , Guzmán Martínez Fernando
Published: June 2023

We describe some properties of the evolution of the COVID-19 pandemic that reveal its behavior as a complex system. The propagation mechanism shows a Poincaré section with fractal dimension 1 < D < 2. The present period of apparent recovery shows a relaxation with non-extensive statistical properties.
Capital intelectual y desempeño de la industria restaurantera de Baja California en época de	COVID-19
Authors: Ibarra Cisneros Manuel Alejandro , Vela Reyna Juan Benito , Ríos Nequis Eric Israel
Published: June 2023

Las organizaciones implementan medidas para tener un mayor desempeño que les permita ser prósperas y competitivas, una de ellas es el capital intelectual. Sin embargo, ante una crisis co mo la pandemia de COVID-19, la industria restaurantera fue de las más afectadas. El objetivo del presente trabajo consiste en determinar si el capital intelectual –dividido en capital humano, estructural y relacional- influyó positivamente en el desempeño de la industria restaurantera de Baja California durante la pandemia COVID-19. La investigación es de tipo explicativa y de corte transversal. Se utilizó el modelo de ecuaciones estructurales por mínimos cuadrados parciales aplicado a 280 restaurantes de Baja California. Se diseñó un cuestionario con respuestas en escala Likert de cinco puntos para medir las cuatro variables de estudio. Se demostró que, durante la pandemia, el capital relacional influyó positivamente sobre el desempeño de los restaurantes. Por su parte, el capital humano y estructural no presentaron ningún grado de significancia. La industria restaurantera no pudo reaccionar ante el azote de la pandemia, por lo que no logró diseñar estrategias para aprovechar el capital humano ni emprendió acciones para fortalecer el estructural. Afortunadamente se centraron en mejorar las relaciones con el cliente buscando satisfacer sus necesidades.
Imágenes digitales obtenidas por dron para estimar el rendimiento de la biomasa en un sitio de pastizal del estado de Durango
Authors: Esquivel Romo Amaury , Gutierrez Guzmán Ulises Noel , Moreno Reséndez Alejandro , Veliz Deras Francisco Gerardo , Arellano Rodríguez Fernando , Bustamante Andrade Jorge Arturo , Rios Vega María Esther , González Mancilla Apolinar
Published: June 2023

La adquisición de imágenes de alta resolución mediante drones y su posterior procesamiento proporcionan información valiosa sobre variables biofísicas de vegetación de pastizales. El objetivo de este estudio fue generar un modelo de predicción de la dinámica de la productividad anual de un pastizal semiárido del norte de México mediante la cobertura vegetal estimada en fotografías digitales obtenidas por dron. Se diseño un sistema de muestreo permanente en el predio ganadero La Cieneguilla. Las variables de estudio medidas fueron la producción de biomasa de corte directo como variable dependiente y la cobertura vegetal estimada en imágenes digitales adquiridas por dron como variable independiente. El número de muestras recogidas de ambas variables fue de 640 durante el año 2020.  Con el 50% de los datos se generó el modelo de predicción y con el otro 50% de los datos el modelo de validación, los modelos de regresión ajustados fueron de la forma Y = β0 + β1X + β2X2 con R2 ajustado = 71.64% y 69.90% respectivamente. Esta metodología propuesta ofrece un medio no destructivo y preciso para el monitoreo y evaluación anual de pastizales en áreas secas.
Adultos mayores: sus prioridades diferenciadas en áreas rurales y urbanas en una población mexicana
Authors: Amador Licona Norma , Guízar Mendoza Juan Manuel
Published: June 2023

Aunque múltiples países en Latinoamérica han firmado la Convención Interamericana sobre la Protección de los Derechos Humanos de las Personas Mayores, aún falta mucho por hacer en esta población. El objetivo de este trabajo es conocer las necesidades actuales que expresan los adultos mayores tanto en el área urbana como rural en una población de México. Mediante la realización de 5 grupos focales (3 en el área urbana y 2 en la rural), junto con la asignación de prioridad de las necesidades identificadas mediante un cuestionario auto-aplicable y anónimo, se identificó que, la necesidad considerada en primer lugar fue la atención en salud, seguido de adecuaciones en la vivienda propias para adultos mayores en todo el grupo. Las necesidades de cultura/diversión y apoyo administrativo, aunque no alcanzaron diferencia significativa en la priorización, la primera presentó tendencia a ser más prioritaria para el área urbana y la segunda para la rural.  El ejercicio, capacitación/desarrollo y apoyo legal se identificaron con mayor prioridad en el área rural que en la urbana. La necesidad de vestido se identificó en los últimos lugares de prioridad sin diferencia de selección entre los grupos.
Representaciones sociales de docentes de educación especial, desde las prácticas de inclusión educativa
Authors: Nieto-Bravo Johan Andrés , García-Manosalva Eneydy Johanna , Muete-Forero Nelson Alonso
Published: June 2023

La inclusión propiciada por el docente en escenarios de enseñanza, garantiza que la diversidad pueda convertirse en una realidad dentro del proceso educativo. Por ello, esta investigación se trazó como objetivo principal, establecer las representaciones sociales sobre la práctica pedagógica de inclusión desarrolladas en la escuela. El proceso metodológico desarrolla una investigación cualitativa con perspectiva epistemológica hermenéutica, esta se desarrolla desde una entrada narrativa con entrevistas semiestructuradas y emplea el análisis de contenido como técnica de recolección de datos. El análisis de las representaciones sociales es un punto de partida para consolidar escenarios de formación docente que contribuyan al horizonte misional de la inclusión como clave de la diversidad. Este proceso consolidó cinco representaciones sociales: La inclusión como un principio de diversidad; la práctica pedagógica como un escenario para el aprendizaje de la perseverancia e independencia; la práctica pedagógica inclusiva mediada por la formación; la adaptabilidad pedagógica a las dificultades encontradas en los escenarios inclusivos; la práctica pedagógica inclusiva mediada por el crecimiento multimodal de todos los actores.
Association of Body Mass Index and Abdominal Obesity with Incidence of Atrial Fibrillation in Heart Failure with Preserved Ejection Fraction
Authors: Huang Xinyi , Liu Xiao , Jiang Yuan , Cao Zhengyu , Wu Maoxiong , Chen Zhiteng , Sun Runlu , Yu Peng , Ma Jianyong , Zhu Wengen , Chen Yangxin , Wu Guifu , Zhang Yuling , Wang Jingfeng
Published: June 2023

Introduction:

The association between obesity and atrial fibrillation (AF) incidence in
heart failure with preserved ejection fraction (HFpEF) patients is currently unclear. Our analyses
and results are based on the whole Treatment of Preserved Cardiac Function Heart Failure with an
Aldosterone Antagonist (TOPCAT) trial (placebo and spironolactone).

Methods:

A total of 2138 subjects without baseline AF were included in the trial. Kaplan-Meier
(K-M) curves and Cox regression with hazard ratios (HRs) and confidence intervals (CIs) were
used to assess the incidence of AF with obesity.

Results:

Of 2138 HFpEF patients without baseline AF, 1165 were obese (body mass index [BMI]≥
30 kg/m2). The K-M curve showed obese patients developed AF more than overweight (25≤
BMI ≤29.9 kg/m2) patients (p=0.013), confirmed by multivariable analysis, while there’s no statistical
difference between overweight and normal weight (18.5≤ BMI ≤24.9 kg/m2) patients. The occurrence
of AF increased by 3% for every kg/m2 increase in BMI (adjusted HR, aHR: 1.03; 95%
CI: 1.00-1.06), with a positive linear association (p for nonlinear: 0.145). Obesity was associated
with AF incidence (aHR: 1.62; 95% CI: 1.05-2.50) compared with non-obesity (including overweight
and normal-weight patients). Abdominal obesity was associated with increased AF incidence
(aHR: 1.70; 95% CI: 1.04-2.77), and AF incidence rose by 18% per centimeter in circumference
(aHR: 1.18; 95% CI:1.04-1.34).

Conclusion:

Obesity and abdominal obesity increase the incidence of AF in HFpEF patients. Further
studies need to determine whether there is a difference in AF in response to spironolactone
across obese HFpEF pheno groups.

Clinical Trial Registration::

URL: https://clinicaltrials.gov. Unique identifier: NCT00094302. Registered
on October 15, 2004
Correlation Analysis between T790M Status and Clinical Characteristics
of Patients with EGFR-sensitive Mutation Advanced NSCLC who
Progressed after the First Generation and First-line EGFR-TKIs
Administration: A Real-world Exploratory Study
Authors: Zhen Ye , Xu Ying-Bo , Deng Ruo-Ying , Li Meng , Ma Min-Ting , Zhou Zhi-Guo , Meng Qing-Ju , Gong Ya-Ning , Zhao Li-Yan , Liu Yi-Bing
Published: June 2023

Aims:

The present study is to investigate the association between T790M status and clinical
characteristics of patients with EGFR-sensitive advanced non-small cell lung cancer (NSCLC)
who progressed the initial epidermal growth factor receptor tyrosine kinase inhibitors (EGFRTKIs)
administration.

Methods:

A total of 167 patients with EGFR-sensitive mutations advanced NSCLC who had successful
genetic tests and progressed the initial EGFR-TKI treatment were included in this study retrospectively.
The clinical and demographic characteristics of these patients were collected, which
were manifested as pathological type, metastasis location, initial biopsy method, initial genetic test
specimens, and baseline gene mutations status. Correlation analysis between T790M status and
these characteristics was performed and prognostic analysis regarding the different subgroups was
carried out accordingly.

Results:

The prevalence of secondary T790M after resistance to initial EGFR-TKIs among the 167
patients was 52.7%. Correlation analysis indicated that the median progression-free Survival (PFS)
to initial EGFR-TKIs >12 months were more likely to develop secondary T790M in univariate
analysis. However, the conclusion failed to show statistically significant in multivariate analysis.
Additionally, patients with intracranial progression of initial EGFR-TKIs therapy were associated
with secondary EGFR-T790M. However, it should be noted that those whose best overall response
was partial response (PR) during the EGFR-TKI therapy were relevant to secondary T790M.
Furthermore, The median PFS of the initial EGFR-TKIs administration was longer among patients
with T790M positive mutation and patients with PR reaction than those without T790M mutation
and patients with stable disease (SD), respectively (median PFS: 13.6 vs. 10.9 months, P=0.023)
and (median PFS: 14.0 vs. 10.1 months, P=0.001).

Conclusion:

This retrospective study highlighted the real-world evidence that the best efficacy and
intracranial progression with initial EGFR-TKIs therapy among patients with advanced NSCLC
might be the promising indicators to predict the occurrence of EGFR-T790M. Patients with PR
reaction and T790M positive mutation conferred longer PFS of the initial EGFR-TKIs administration.
Also, the conclusion should be confirmed in more patients with advanced NSCLC subsequently.
Recent Updates on Transdermal Drug Delivery Approaches for the
Management of Gout and its Clinical Perspective
Authors: Harwansh Ranjit K. , Mishra Soumya , Mazumder Rupa , Deshmukh Rohitas , Rahman Akhlaquer
Published: June 2023

Oral and injectable drug administration have recently been replaced with transdermal
drug delivery (TDD) approaches, which are less intrusive, less likely to be rejected by patients,
and easier to administer. There is still room for improvement in the treatment of gout with the use
of a TDD system. Gout has become a worldwide epidemic and a severe threat to human beings.
Gout treatment can be accomplished in various ways, including orally and intravenously. Several
traditional options are still useless, cumbersome, and potentially dangerous. Hence, gout therapeutic
options are desperately required for more effective and less toxic drug delivery methods. Antigout
medications using TDD could substantially influence obese people in the future, even if most
trials are still in the animal stages. Thus, this review aimed to provide a concise overview of recent
TDD technologies and anti-gout medication delivery methods that improved therapeutic efficacy
and bioavailability. Moreover, clinical updates on investigational drugs have been discussed to
address the potential findings against gout.
Study on the Electrical and Geometrical Parameters of Micro Electrical
Discharge Machining
Authors: Tafraouti Asmae , Layouni Yasmina , Kleimann Pascal
Published: June 2023

Introduction:

Micro-Electrical Discharge Machining (μEDM) is a technique for noncontact
machining of conductive or semiconductor materials. It is mainly adapted to machining hard
materials. Its principle is based on the creation of electrical discharges between the micro tool and the
workpiece, which are immersed in a dielectric.

Methods:

Methods: It is a complementary process to mechanical or laser micromachining techniques or microelectronics (RIE, DRIE, LIGA). These methods can reach a resolution of 50 nm, but their main drawback is that they are mainly dedicated to silicon. The µEDM process depends on several physical, geometrical, and/or electrical parameters that need to be optimized in order to achieve a resolution lower than 5 µm in a reproducible way. The objective of this paper is to study the effect of the applied voltage VEE and the micro-tool diameter on the machining performances (removed volume, lateral gap, machining depth, and crater shape).

Result:

Result: The optimal parameters were used during drilling holes. An applied voltage of VEE = 50V was used as an optimal parameter.

Conclusion:

Concerning the diameter of the micro tool, we propose to use large diameter wires
(Φ=250μm; Φ=125μm) during the roughing phase for machining complex structures and small diameter
micro tools (Φ=80μm; Φ=40μm; Φ=20μm) during the finishing phase.
Computational Operations Research Issues
Authors: Polanco Carlos
Published: June 2023

This chapter introduces Discrete and Continuous-Time Markov Chain
Process aimed to predict the behavior of a waiting line, based on the probabilities
of going from the state i to the state j, and also from velocity rates lambda and
retracement mu. In both cases a numerical example is provided that shows the mechanics of both random walks as well as the pertinent observations when altering
these parameters, and discusses the possibility of these parameters being altered in
real time in an unsupervised algorithm.
Designing Noscapine-based Anti-Cancer Agents
Authors: Silva Santos-Júnior Paulo F. , Nascimento Igor J. S. , Silva-Júnior Edeildo F.
Published: June 2023

Cancer is the second leading cause of death globally, in which factors, such
as tobacco, radiation, and obesity contribute to this alarming data. Among the available
pharmacotherapy, natural products, such as noscapine, have historical evidence in
treating this disease, showing promising results aimed at inhibiting tubulin. In this
context, this remarkable molecule has been tested as a conjugated drug in treating the
COVID-19 pandemic. In this chapter, we demonstrate noscapine structurally-related
compounds, analyzing them based on SAR studies, and discuss the most promising
results reported so far.
Biogenic Amine and Amino Acid Derivatives as Carbonic Anhydrase Modulators
Authors: Berrino Emanuela , Carta Fabrizio
Published: June 2023

Biogenic amines (BAs) and amino acids (AAs) are essential components of
every living organism, being the precursors of vital compounds, such as hormones,
alkaloids, nucleic acids and proteins, among others. They are directly involved in many
metabolic processes, growth regulation, cellular transmission and diseases. A plethora
of biological substrates yet to be fully identified are the targets of BAs and AAs. The
Carbonic Anhydrases (CAs; EC 4.2.1.1) are listed among them. These metalloenzymes
are virtually expressed in every living organism, with eight genetically distinct families
described to date. CAs main biological function is represented by CO2
hydration
catalysis. Amino acids and amines are usually reported as efficient CA activators and
are thus potentially useful for therapeutic purposes in aging and neurodegenerative
diseases as well as tissue engineering. To date, polyamines are the only exception as
they were identified to act as CA inhibitors. Here, we will review the main
contributions in the field covering the effects of such crucial molecules on CAs
expressed in various organisms (mammals, fungi, protozoan, bacteria and archaea).
Synthetic analogues of amines and amino acids obtained from various drug design
approaches, will also be considered.
Using rice bran as a patisserie ingredient in project-based learning in the food engineering study program at UNY
Authors: Auliana Rizqie , Razzaq Abdul Rasid Bin Abdul
Published: June 2023

The number of people with non-communicable diseases (NCD) and degenerative diseases tends to increase from time to time. The diseases are the results of a bad diet and free radicals. Rice bran is one of the food sources containing high fiber and antioxidants. However, it is rarely used as a food product. Rice bran may become the ingredient of patisserie products for NCD diet. These rice bran-based patisseries are made in the Food Engineering Education study program of the Faculty of Engineering at UNY. Through Project-based Learning (PjBL), the fourth-semester students taking the Bakery Processing course learned how to make rice bran products. There were 30 students participating in this research which was conducted from June to September 2018. Based on the result of this study, it was found that the average of students’ knowledge pre-test score was 20.90, and the posttest average score was 23.10. In terms of students’ attitudes, the average pre-test score was 46.25, and the average post-test score was 49.80. The students’ skills at making rice bran-based patisseries are considered “Good” because the score ranges between 93 and 100. PjBL is considered effective to be implemented in the Food Engineering class because it can improve students’ knowledge, attitude, and skill scores.
Youtube as an alternative to learning media: a case study
Authors: Cholik Mochamad , Umaroh Susi Tri , Rijanto Tri , Soeryanto Soeryanto
Published: June 2023

21st century-era learning is undergoing significant changes. The learning process is carried out with a combination of various digital media that can be accessed easily by students and teachers in learning. Based on the covid-19 pandemic, it is also an effort to follow the development of technology and information. Vocational students in the Field of Automotive Engineering Expertise must have competence in maintenance and repair in vehicles. Therefore, with learning that still cannot be face-to-face in full, they must utilize technology and information to support learning and understand theoretical and practical materials. This research aims to find out the level of use of YouTube as a medium to support the learning of vocational students in the field of automotive engineering expertise. The sample taken in this study was a student of SMK Senopati Sidoarjo East Java Indonesia. They are majoring in Light Vehicle Engineering and Motorcycle Business Engineering. This study shows that YouTube is beneficial for students to support online learning in the pandemic period and overcome problems in the automotive field. There are tutorial videos that are very easy to access to help students overcome the pain in their vehicles and understand learning materials.
High speed railway operations expert training development in Indonesia
Authors: Riyanta Wawan , Jannah Anggra Iftitah Miftakhul
Published: June 2023

KCIC Phase I Training Program will accommodate 500 Participants from the total HR needs of PT KCIC from 1,452 people. The focus is on increasing competence on the Operation System, Passenger Service, and Maintenance divided into 21 Training Posts, most of the participants came from Fresh Graduates who entered the Entry Level. Required Competence Levels ability to apply knowledge and skill High Speed Railway Technology. technical executive level for High Speed Railway operation and maintenance for Electric Multiple Unit (EMU) KCIC400AF Type from China. Gaps participant competence between existing competence levels and required competence levels calculate 100%, thus the training program will be carried out as a whole in accordance with the training curriculum of the HSRCC. The training program consists of 4 parts consisting of (1) Indonesian regulation, instructors from Indonesian Railway Polytechnic; (2) Professional Knowledge, instructor from Tianjin Railway Technical and Vocational College and Southwest Jiaotong University; (3) Safety regulation, instructor from China Railway – Beijing; and (4) Practical skills instructor from China Railway – Beijing. The delivery method uses the online class method which will be accompanied by interpreters and assistant lecturers in each class. With the language interpretation stage, a multiplier coefficient of 2.5 is obtained from normal lesson hours in the HSRCC curriculum if it is implemented in Indonesian participants. The duration of the training implementation about 1 – 8.5 Month. The next competency requirement is High Speed Railway trainer from Indonesia. With the stipulation, which was conveyed by the HSRCC, that participants who have taken the training phase I and received an evaluation score of training and competency certification above the average of other participants, are able to take part in the Training of Trainers for High Speed Railway and pass the Competency Test of Trainer Candidates.
Contributing factors in learning programmable logic controller using path analysis
Authors: Zakarijah Masduki , Utomo Pramudi , Rochayati Umi , Mashoedah Mashoedah , Suprapto Suprapto , Sony Arya
Published: June 2023

Learning Programmable Logic Controller (PLC) programming is influenced by several factors, that is: lecturer competence in PLC programming, adequacy of information technology infrastructure in learning, availability of learning media, vocational guidance procedures, and learning motivation. The purpose of this study: (a) to describe the factors that contribute to PLC programming learning, (b) to formulate a PLC programming competency model, and (c) to examine the determinants of PLC programming learning. Model testing method using Path Analysis.  The results of this analysis are expected to be able to describe the relational patterns between variables in learning PLC programming, as well as the direct and indirect impacts on the mastery of PLC programming competencies.  Keywords: PLC programming competency, path analysis, vocational education.