bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of genetic fidelity and composition: Mixed elicitors enhance triterpenoid and flavonoid biosynthesis of Glycyrrhiza uralensis Fisch. tissue cultures
Authors: Wang Juan , Li Jing , Wu Xiaolei , Liu Shujie , Li Hongfa , Gao Wenyuan
Published: February 2016

Glycyrrhiza uralensis has acquired significant importance due to its medicinal properties and health function. In this study, the quality of G. uralensis adventitious roots was evaluated in terms of genetic stability, active compounds, and anti‐inflammatory activity. Monomorphic banding pattern obtained from the mother plant and tissue cultures of G. uralensis with randomly amplified polymorphic DNA markers confirmed the genetic stability of adventitious roots. Neoliquiritin (neoisoliquiritin), ononin, liquiritin, and glycyrrhizic acid were identified from G. uralensis adventitious roots on the basis of high‐performance liquid chromatography–electrospray ionization–tandem mass spectrometry analysis. This study also revealed that adventitious roots possessed a better anti‐inflammatory effect than native roots. To increase the contents of G. uralensis active components, elicitors were used in the adventitious roots culture. The combination of methyl jasmonate and phenylalanine synergistically stimulated the accumulation of glycyrrhetinic acid (0.22 mg/g) and total flavonoid (5.43 mg/g) compared with single treatment. In conclusion, G. uralensis adventitious roots can be an exploitable system for the production of licorice.
Elevated congenital anomaly rates and incorporated cesium‐137 in the Polissia region of Ukraine
Authors: Wertelecki Wladimir , Koerblein Alfred , Ievtushok Bogdana , Zymak‐Zakutnia Nataliya , Komov Oleksandr , Kuznietsov Illia , Lapchenko Serhiy , Sosyniuk Zoriana
Published: February 2016

Background

Investigations soon after the 1986 Chornobyl (Chernobyl in Russian) accident of exposed populations residing elsewhere in Europe led government and international agencies to conclude that exposures to cesium‐137 (Cs‐137) were not teratogenic. Our observations of elevated population rates of neural tube defects (NTDs) and microcephaly and microphthalmia (M/M) in the Rivne Province in Ukraine, which were among the highest in Europe, prompted this follow‐up investigation inclusive of whole‐body counts (WBCs) of Cs‐137 among ambulatory patients and pregnant women residing in Polissia, the most polluted region in Rivne.

Methods

Yearly (2000–2012) population rates of NTDs and M/M and WBC patterns of ambulatory patients (2001–2010) and pregnant women (2011–2013) in Polissia and non‐Polissia regions of Rivne were analyzed.

Results

The NTD and M/M population rates in Rivne remain elevated and are statistically significantly higher in Polissia than in non‐Polissia. The WBCs among residents in Polissia are statistically significantly higher than among those from non‐Polissia.

Conclusion

NTD and M/M rates are highest in the Polissia region of Rivne and are among the highest in Europe. In Polissia, the WBCs of Cs‐137 are above officially set permissible upper limits. The results are based on aggregate data of NTDs and M/Ms and average WBC values. Further investigations of causality of the high rates of NTDs and M/Ms are needed and urgent strengthening policies and implementations to reduce exposures to teratogens, in particular radioactive nuclides and alcohol, and consumption of folic acid supplements are indicated. Birth Defects Research (Part A) 106:194–200, 2016. © 2016 Wiley Periodicals, Inc.
Cross‐talk between circadian clocks, sleep‐wake cycles, and metabolic networks: Dispelling the darkness
Authors: Ray Sandipan , Reddy Akhilesh B.
Published: February 2016

Integration of knowledge concerning circadian rhythms, metabolic networks, and sleep‐wake cycles is imperative for unraveling the mysteries of biological cycles and their underlying mechanisms. During the last decade, enormous progress in circadian biology research has provided a plethora of new insights into the molecular architecture of circadian clocks. However, the recent identification of autonomous redox oscillations in cells has expanded our view of the clockwork beyond conventional transcription/translation feedback loop models, which have been dominant since the first circadian period mutants were identified in fruit fly. Consequently, non‐transcriptional timekeeping mechanisms have been proposed, and the antioxidant peroxiredoxin proteins have been identified as conserved markers for 24‐hour rhythms. Here, we review recent advances in our understanding of interdependencies amongst circadian rhythms, sleep homeostasis, redox cycles, and other cellular metabolic networks. We speculate that systems‐level investigations implementing integrated multi‐omics approaches could provide novel mechanistic insights into the connectivity between daily cycles and metabolic systems.
Bio‐Innovativ: Netzwerk Lehrerfortbildung
Authors: Wenning Silvia , Sandmann Angela
Published: February 2016

Fachdidaktisch und fachlich innovatives Know‐how für Lehrkräfte bietet die Didaktik der Biologie der Universität Duisburg‐Essen in dem Netzwerk Bio‐Innovativ an. Kern der Konzeption ist die Zusammenarbeit und gegenseitige Unterstützung von Akteuren aller Lehrerbildungsphasen. Die Fortbildungsangebote für Biologielehrerinnen und ‐lehrer aller Schulformen sind theoriebasiert konzipiert, greifen aktuelle Forschung und bildungspolitische Schwerpunkte auf und intendieren den Transfer in die Schulpraxis. Derzeit nutzen mehr als 300 Teilnehmerinnen und Teilnehmer pro Jahr die Angebote mit steigender Tendenz und hervorragenden Bewertungen, wie die Evaluation zeigt.
Effiziente Versuchsplanung nach Taguchi
Authors: Hauk Andrea
Published: February 2016

Waren Sie schon einmal an der Optimierung eines Experiments in der Entwicklung beteiligt? Dann kennen Sie sicher die “one‐factor‐at‐a‐time” Methode, bei der jeweils eine Einflussgröße variiert wird, während alle anderen Faktoren konstant bleiben. Mit Glück kommt man hier schnell zum Ziel. Mitunter ist diese Methode aber aufwändig und langwierig und man optimiert gefühlt bis zum Erbrechen .
Randomized clinical trial of prehabilitation before planned liver resection
Authors: Dunne D F J , Jack S , Jones R P , Jones L , Lythgoe D T , Malik H Z , Poston G J , Palmer D H , Fenwick S W
Published: February 2016

Background

Patients with low fitness as assessed by cardiopulmonary exercise testing (CPET) have higher mortality and morbidity after surgery. Preoperative exercise intervention, or prehabilitation, has been suggested as a method to improve CPET values and outcomes. This trial sought to assess the capacity of a 4-week supervised exercise programme to improve fitness before liver resection for colorectal liver metastasis.

Methods

This was a randomized clinical trial assessing the effect of a 4-week (12 sessions) high-intensity cycle, interval training programme in patients undergoing elective liver resection for colorectal liver metastases. The primary endpoint was oxygen uptake at the anaerobic threshold. Secondary endpoints included other CPET values and preoperative quality of life (QoL) assessed using the SF-36®.

Results

Thirty-eight patients were randomized (20 to prehabilitation, 18 to standard care), and 35 (25 men and 10 women) completed both preoperative assessments and were analysed. The median age was 62 (i.q.r. 54–69) years, and there were no differences in baseline characteristics between the two groups. Prehabilitation led to improvements in preoperative oxygen uptake at anaerobic threshold (+1·5 (95 per cent c.i. 0·2 to 2·9) ml per kg per min) and peak exercise (+2·0 (0·0 to 4·0) ml per kg per min). The oxygen pulse (oxygen uptake per heart beat) at the anaerobic threshold improved (+0·9 (0·0 to 1·8) ml/beat), and a higher peak work rate (+13 (4 to 22) W) was achieved. This was associated with improved preoperative QoL, with the overall SF-36® score increasing by 11 (95 per cent c.i. 1 to 21) (P = 0·028) and the overall SF-36® mental health score by 11 (1 to 22) (P = 0·037).

Conclusion

A 4-week prehabilitation programme can deliver improvements in CPET scores and QoL before liver resection. This may impact on perioperative outcome. Registration number: NCT01523353 (https://clinicaltrials.gov).
Enzymatic generation of peptides from potato proteins by selected proteases and characterization of their structural properties
Authors: Waglay Amanda , Karboune Salwa
Published: February 2016

The use of low grade starting material for the generation of peptides with bioactivity properties is of interest. The proteins from the potato starch industry byproduct is a promising source, as several health benefits may be associated with their hydrolysates. The efficiency of selected proteases (Novo Pro‐D, Alcalase, Flavourzyme, and Papain), exhibiting different substrate specificities and cleavage action modes, to hydrolyze potato protein isolate (patatin and protease inhibitors) was investigated. Novo Pro‐D resulted in the lowest degree of hydrolysis, whereas Alcalase, Flavourzyme, and Papain exhibited a high catalytic efficiency for the hydrolysis of potato proteins. The degree of hydrolysis behaved in a concentration dependent manner. However, the end‐product profile (peptides and free amino acids) was dependent not only on the protease specificity, its cleavage action mode (endo/exo) and the availability of the intermediate substrates but also on the contribution of the protease inhibitors to the reaction kinetics through their inhibitory effects. Indeed, the dependence of the exo‐activity on the catalytic efficiency of the endo‐action of protease was shown to be significant. Papain generated more unique peptide sequences with homology assessment matching several potato proteins when compared with Flavourzyme. This can be attributed to the high exo‐peptidase activity of Flavourzyme resulting in the generation of shorter peptides which were difficult to match. Flavourzyme produced more peptides originated from patatin fraction, whereas Papain resulted in the release of more peptides corresponding to the protease inhibitor fractions. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 32:420–429, 2016
Machine learning‐based classification of diffuse large B‐cell lymphoma patients by eight gene expression profiles
Authors: Zhao Shuangtao , Dong Xiaoli , Shen Wenzhi , Ye Zhen , Xiang Rong
Published: February 2016

Gene expression profiling (GEP) had divided the diffuse large B‐cell lymphoma (DLBCL) into molecular subgroups: germinal center B‐cell like (GCB), activated B‐cell like (ABC), and unclassified (UC) subtype. However, this classification with prognostic significance was not applied into clinical practice since there were more than 1000 genes to detect and interpreting was difficult. To classify cancer samples validly, eight significant genes (MYBL1, LMO2, BCL6, MME, IRF4, NFKBIZ, PDE4B, and SLA) were selected in 414 patients treated with CHOP/R‐CHOP chemotherapy from Gene Expression Omnibus (GEO) data sets. Cutoffs for each gene were obtained using receiver–operating characteristic curves (ROC) new model based on the support vector machine (SVM) estimated the probability of membership into one of two subgroups: GCB and Non‐GCB (ABC and UC). Furtherly, multivariate analysis validated the model in another two cohorts including 855 cases in all. As a result, patients in the training and validated cohorts were stratified into two subgroups with 94.0%, 91.0%, and 94.4% concordance with GEP, respectively. Patients with Non‐GCB subtype had significantly poorer outcomes than that with GCB subtype, which agreed with the prognostic power of GEP classification. Moreover, the similar prognosis received in the low (0–2) and high (3–5) IPI scores group demonstrated that the new model was independent of IPI as well as GEP method. In conclusion, our new model could stratify DLBCL patients with CHOP/R‐CHOP regimen matching GEP subtypes effectively.
The Effect of Dissolved Gases as Impurities on Crystallization
Authors: Huang Jiting , Yin Qiuxiang , Ulrich Joachim
Published: February 2016

Gases dissolved in solvents are usually low in amount but introduce many impurities to certain systems, thus creating disadvantages or advantages which have so far been seldom reported. Evidence of the effects of dissolved gases as impurities on crystallization is provided here. Four types of gases were used. By bubbling these gases into a solvent, gas‐saturated solutions were prepared, whereas the degassed solvent was used as a comparison. The results show that different types of gases (including the degassed solvent) do change the thermodynamic and kinetic aspects to a different degree. The pH values of the epsomite solutions that were saturated with different types of gases turned out to be different compared to the untreated solutions, indicating that the gas‐liquid‐solid equilibrium varied.
Phenanthrene Purification: Comparison of Zone Melting and Co‐Crystallization
Authors: Burel Antoine , Brugman Sander J. T. , Mignot Mélanie , Cartigny Yohann , Tisse Séverine , Couvrat Nicolas , Peulon‐Agasse Valérie , Cardinael Pascal , Coquerel Gérard
Published: February 2016

The purification of phenanthrene is a prerequisite before studying its solid‐solid phase transition at the molecular scale. Two purification methods, namely, zone melting and co‐crystallization with 3,5‐dinitrobenzoic acid, were separately studied and compared, in view of reaching ultrapurity which means a purity of > 99.9 mol %. An explanation of the relationship between the efficiency of both techniques by using phase diagrams has been attempted. A novel strategy is proposed to optimize phenanthrene ultrapurification based on a combination of the two methods.
Synthetic Control of the Excited‐State Dynamics and Circularly Polarized Luminescence of Fluorescent “Push–Pull” Tetrathia[9]helicenes
Authors: Yamamoto Yuki , Sakai Hayato , Yuasa Junpei , Araki Yasuyuki , Wada Takehiko , Sakanoue Tomo , Takenobu Taishi , Kawai Tsuyoshi , Hasobe Taku
Published: February 2016

A series of fluorescent “push‐pull” tetrathia[9]helicenes based on quinoxaline (acceptor) fused with tetrathia[9]helicene (donor) derivatives was synthesized for control of the excited‐state dynamics and circularly polarized luminescence (CPL) properties. In this work, introduction of a quinoxaline onto the tetrathia[9]helicene skeleton induced the “push–pull” character, which was enhanced by further introduction of an electron‐releasing Me2N group or an electron‐withdrawing NC group onto the quinoxaline unit (denoted as Me2N‐QTTH and NC‐QTTH, respectively). These trends were successfully discussed in terms of by electrochemical measurements and density functional theory (DFT) calculations. As a consequence, significant enhancements in the fluorescence quantum yields (ΦFL) were achieved. In particular, the maximum ΦFL of Me2N‐QTTH was 0.43 in benzene (NC‐QTTH: ΦFL=0.30), which is more than 20 times larger than that of a pristine tetrathia[9]helicene (denoted as TTH; ΦFL=0.02). These enhancements were also explained by kinetic discussion of the excited‐state dynamics such as fluorescence and intersystem crossing (ISC) pathways. Such significant enhancements of the ΦFL values thus enabled us to show the excellent CPL properties. The value of anisotropy factor gCPL (normalized difference in emission of right‐handed and left‐handed circularly polarized light) was estimated to be 3.0×10−3 for NC‐QTTH.
Alkaline‐Earth‐Catalysed Cross‐Dehydrocoupling of Amines and Hydrosilanes: Reactivity Trends, Scope and Mechanism
Authors: Bellini Clément , Dorcet Vincent , Carpentier Jean‐François , Tobisch Sven , Sarazin Yann
Published: February 2016

Alkaline‐earth (Ae=Ca, Sr, Ba) complexes are shown to catalyse the chemoselective cross‐dehydrocoupling (CDC) of amines and hydrosilanes. Key trends were delineated in the benchmark couplings of Ph3SiH with pyrrolidine ortBuNH2. Ae{E(SiMe3)2}2⋅(THF)x(E=N, CH;x=2–3) are more efficient than {N^N}Ae{E(SiMe3)2}⋅(THF)n(E=N, CH;n=1–2) complexes (where {N^N}−={ArN(o‐C6H4)C(H)=NAr}−with Ar=2,6‐iPr2‐C6H3) bearing an iminoanilide ligand, and alkyl precatalysts are better than amido analogues. Turnover frequencies (TOFs) increase in the order Ca<Sr30 products) includes diamines and di(hydrosilane)s. Kinetic analysis of the Ba‐promoted CDC of pyrrolidine and Ph3SiH shows that 1) the kinetic law is rate=k[Ba]1[amine]0[hydrosilane]1, 2) electron‐withdrawingp‐substituents on the arylhydrosilane improve the reaction rate and 3) a maximal kinetic isotopic effect (kSiH/kSiD=4.7) is seen for Ph3SiX (X=H, D). DFT calculations identified the prevailing mechanism; instead of an inaccessible σ‐bond‐breaking metathesis pathway, the CDC appears to follow a stepwise reaction path with N−Si bond‐forming nucleophilic attack of the catalytically competent Ba pyrrolide onto the incoming silane, followed by rate limiting hydrogen‐atom transfer to barium. The participation of a Ba silyl species is prevented energetically. The reactivity trend Ca<Sr<Ba results from greater accessibility of the metal centre and decreasing Ae−Namidebond strength upon descending Group 2.
Synthesis and Applications of Silyl 2‐Methylprop‐2‐ene‐1‐sulfinates in Preparative Silylation and GC‐Derivatization Reactions of Polyols and Carbohydrates
Authors: Marković Dean , Tchawou Wandji Augustin , Novosjolova Irina , Laclef Sylvain , Stepanovs Dmitrijs , Turks Māris , Vogel Pierre
Published: February 2016

Trimethylsilyl, triethylsilyl, tert‐butyldimethylsilyl, and triisopropylsilyl 2‐methylprop‐2‐ene‐1‐sulfinates were prepared through (CuOTf)2⋅C6H6‐catalyzed sila‐ene reactions of the corresponding methallylsilanes with SO2 at 50 °C. Sterically hindered, epimerizable, and base‐sensitive alcohols gave the corresponding silyl ethers in high yields and purities at room temperature and under neutral conditions. As the byproducts of the silylation reaction (SO2+isobutylene) are volatile, the workup was simplified to solvent evaporation. The developed method can be employed for the chemo‐ and regioselective semiprotection of polyols and glycosides and for the silylation of unstable aldols. The high reactivity of the developed reagents is shown by the synthesis of sterically hindered per‐O‐tert‐butyldimethylsilyl‐α‐d‐glucopyranose, the X‐ray crystallographic analysis of which is the first for a per‐O‐silylated hexopyranose. The per‐O‐silylation of polyols, hydroxy carboxylic acids, and carbohydrates with trimethylsilyl 2‐methylprop‐2‐ene‐1‐sulfinate was coupled with the GC analysis of nonvolatile polyhydroxy compounds both qualitatively and quantitatively.
Efficient Charge Separation between Bi and Bi2MoO6 for Photoelectrochemical Properties
Authors: Ma Ying , Jia Yulong , Wang Lina , Yang Min , Bi Yingpu , Qi Yanxing
Published: February 2016

Herein, porous Bi/Bi2MoO6 nanoparticles have been prepared by a facile in‐situ reduction approach. Moreover, the morphology and Bi content of product could be controlled by varying the reaction time. By controlled fabrication, the desired porous Bi2MoO6 nanostructure with incorporation of Bi was obtained and exhibited high photoelectric and photocatalytic activity. In particular, the samples yield a photocurrent density of 320 μA cm−2, which is 3.2 times that of the pure Bi2MoO6 nanosheet (100 μA cm−2) under the same conditions. UV/Vis diffuse reflectance spectroscopy analysis confirmed the surface plasmon resonance in the as‐prepared porous nanoparticles. The improved photoelectric properties could be the synergistic effect of the porous structure with large surface area and effective electron‐hole separations between Bi and Bi2MoO6.
Microwave‐Assisted Copper‐Catalyzed Oxidative Cyclization of Acrylamides with Non‐Activated Ketones
Authors: Zhao Yaping , Sharma Nandini , Sharma Upendra K. , Li Zhenghua , Song Gonghua , Van der Eycken Erik V.
Published: February 2016

An operationally simple and efficient microwave‐assisted protocol for the oxidative cyclization of acrylamide derivatives with non‐activated ketones to generate 3,3‐disubstituted oxindoles is described. The reaction proceeds by a copper‐catalyzed tandem radical addition/cyclization strategy and tolerates a series of functional groups with moderate to excellent yields.
Insertion Reactions of Neutral Phosphidozirconocene Complexes as a Convenient Entry into Frustrated Lewis Pair Territory
Authors: Normand Adrien T. , Daniliuc Constantin G. , Wibbeling Birgit , Kehr Gerald , Le Gendre Pierre , Erker Gerhard
Published: February 2016

Neutral phosphidozirconocene complexes [Cp2Zr(PR2)Me] (Cp=cyclopentadienyl; 1a: R=cyclohexyl (Cy); 1b: R=mesityl (Mes); 1c: R=tBu) undergo insertion into the Zr−P bond by non‐enolisable carbonyl building blocks (O=CR′R′′), such as benzophenone, aldehydes, paraformaldehyde or CO2, to give [Cp2Zr(OCR′R′′PR2)Me] (3–7). Depending on the steric bulk around P, complexes 3–7 react with B(C6F5)3 to give O‐bridged cationic zirconocene dimers that display typical frustrated Lewis pair (FLP)/ambiphilic ligand behaviour. Thus, the reaction of {[Cp2Zr(μ‐OCHPhPCy2)][MeB(C6F5)3]}2 (10a) with chalcone results in 1,4 addition of the Zr+/P FLP, whereas the reaction of {[Cp2Zr(μ‐OCHFcPCy2)][MeB(C6F5)3]}2 (11a; Fc=(C5H4)CpFe) with [Pd(η3‐C3H5)Cl]2 yields the unique Zr−Fe−Pd trimetallic complex 13a, which has been characterised by XRD analysis.
Unprecedented Oxycyanation of Methylenecyclopropanes for the Facile Synthesis of Benzoxazine Compounds Containing a Cyano Group
Authors: Yuan Yu‐Chao , Yang Hai‐Bin , Tang Xiang‐Ying , Wei Yin , Shi Min
Published: February 2016

A novel intramolecular oxycyanation of methylenecyclopropanes is reported that proceeds through oxidative cleavage of the N−CN bond and subsequent palladium transfer from N to O of the amide group. A range of substituted benzo[d][1,3]oxazines with a cyano group are readily furnished by this newly developed oxycyanation reaction. Tris(4‐trifluoromethylphenyl)phosphine as a ligand has been found to be crucial to effectively promote the transformation with high chemo‐ and regioselectivity. Moreover, the reaction outcome can be significantly affected by the electronic effect of the acyl group attached to the nitrogen atom of methylenecyclopropanes. When R3 is a chloromethyl group, the pyrrolo[2,3‐b]quinoline derivative is obtained by thermal‐induced [3+2] cycloaddition of methylenecyclopropane to the methanediimine intermediate.
Metal‐Free Oxidation of Primary Amines to Nitriles through Coupled Catalytic Cycles
Authors: Lambert Kyle M. , Bobbitt James M. , Eldirany Sherif A. , Kissane Liam E. , Sheridan Rose K. , Stempel Zachary D. , Sternberg Francis H. , Bailey William F.
Published: February 2016

Synergism among several intertwined catalytic cycles allows for selective, room temperature oxidation of primary amines to the corresponding nitriles in 85–98 % isolated yield. This metal‐free, scalable, operationally simple method employs a catalytic quantity of 4‐acetamido‐TEMPO (ACT; TEMPO=2,2,6,6‐tetramethylpiperidine N‐oxide) radical and the inexpensive, environmentally benign triple salt oxone as the terminal oxidant under mild conditions. Simple filtration of the reaction mixture through silica gel affords pure nitrile products.
ChemInform Abstract: Magnetic and X‐Ray Absorption Studies on the RE5X2Sb6 (RE: Eu, Yb; X: Al, Ga, In) Compounds.
Authors: Subbarao Udumula , Sarkar Sumanta , Joseph Boby , Peter Sebastian C.
Published: February 2016

The title compounds (obtained by a high frequency induction heating method) are characterized by magnetic measurements, XANES, and XRD.
ChemInform Abstract: Crystal Structure of the Th2Ni10Al15 Phase Solved Using Electron Diffraction Tomography.
Authors: Yaniv G. , Meshi L.
Published: February 2016

Intermetallic Th2Ni10Al15 is prepared by arc melting of the elements followed by homogenization annealing under Ar (Ta foil in quartz capsule, 800 °C, 4 weeks).
ChemInform Abstract: Observations of Temperature Stability of γ‐Zirconium Hydride by High‐Resolution Neutron Powder Diffraction.
Authors: Wang Zhiyang , Steuwer Axel , Liu Nanxi , Maimaitiyili Tuerdi , Avdeev Maxim , Blomqvist Jakob , Bjerken Christina , Curfs Caroline , Kimpton Justin A. , Daniels John E.
Published: February 2016

In the view of the problem of delayed hydride cracking via hydrogen embrittlement of fuel claddings of the nuclear industry, a Zr‐50D alloy is prepared by heating Zr powder with gaseous D2 (pressure furnace, 573 K, 1.9 bar, 10 h).
ChemInform Abstract: LiMoO3(IO3), a Novel Molybdenyl Iodate with Strong Second‐Order Optical Nonlinearity.
Authors: Reshak A. H. , Auluck S.
Published: February 2016

Linear and nonlinear optical susceptibilities of the title compound are calculated based on reported crystallographic data and compared with other available experimental data.
ChemInform Abstract: Origin of the Strong Optical Nonlinearity of Tellurium Oxide—Based Compounds: The Specific Case of BaTe2O6.
Authors: Hamani D. , Plat A. , Colas M. , Cornette J. , Masson O. , Mirgorodsky A. P. , Thomas P.
Published: February 2016

Single crystals of BaTe2O6 (BaTeIVTeVIO6) are grown from a stoichiometric mixture of TeO2 and BaCO3 in air (Au crucible, 710 °C, 10 h; cooling to 645 °C at a rate of 1 °C/h and to 25 °C at a rate of10 °C/h).
ChemInform Abstract: Synthesis and Luminescence Properties of Novel Red‐Emitting R3P4O13:Bi2+ (R: Sr and Ba) Phosphors.
Authors: Cao Renping , Cao Yunling , Fu Ting , Jiang Shenhua , Li Wensheng , Luo Zhiyang , Fu Jingwei
Published: February 2016

M3P4O13:xBi2+ (M: Sr, Ba; x = 0—4 mol%) are prepared by sintering stoichiometric mixtures of SrCl2 (BaCl2), NH4H2PO4, and Bi2O3 in air (alumina crucible, 1.
ChemInform Abstract: Rapid Synthesis and Effect of High Temperature and High Pressure Processing on the Structure and Thermoelectric Properties of Clathrate Ba8Cu6Si16Ge24.
Authors: Sun Bing , Jia Xiaopeng , Huo Dexuan , Sun Hairui , Zhang Yuewen , Liu Binwu , Liu Haiqiang , Kong Lingjiao , Ma Hongan
Published: February 2016

The title clathrate is synthesized from a stoichiometric mixture of the elements and BaSi2 (3—5 GPa, 1125 K, 30 min).
ChemInform Abstract: Ta5GeB2: New T2 Superconductor Phase.
Authors: Correa L. E , da Luz M. S. , de Lima B. S. , Cigarroa O. V. , da Silva A. A. A. P. , Coelho G. C. , Fisk Z. , Machado A. J. S.
Published: February 2016

Polycrystalline samples of Ta5Ge3‐xBx (x = 0.2—1) are prepared by solid‐state reaction of stoichiometric mixtures of the elements (quartz ampoules, 1.
ChemInform Abstract: Nitrogen‐ and Phosphorus‐Doped Nanoporous Graphene/Graphitic Carbon Nitride Hybrids as Efficient Electrocatalysts for Hydrogen Evolution.
Authors: Shinde Sambhaji S. , Sami Abdul , Lee Jung‐Ho
Published: February 2016

The title hybrid electrocatalysts are prepared by oxidation of graphene with H2O2 at 70 °C followed by N‐ and P‐doping via thermal exfoliation of dicyandiamide and triphenylphosphine, resp., at 900 °C, and reaction of the products with graphitic C3N4 at 600 °C.
ChemInform Abstract: Synthesis and Characterization of a Novel Alkaline Earth Niobate Ca0.5Sr0.5Nb2O6.
Authors: Dudhe C. M , Nagdeote S. B. , Palikundwar U. A.
Published: February 2016

The title compound is prepared by addition of Nb2O5 dissolved in HF to an aqueous solution of CaCl2 and SrCl2 followed by stirring for 3—4 h.
ChemInform Abstract: A New Compound in the Nb—V—Sb—O System and Its Physicochemical Characteristic.
Authors: Filipek Elzbieta , Piz Mateusz
Published: February 2016

A new compound of the formula Nb6VSb3O25 is obtained by calcination of T‐Nb2O5, V2O5 and α‐Sb2O4 in the molar ratio of 6:1:3.
ChemInform Abstract: Synthesis of Bis(oxazoline) Ligands Possessing C‐5 gem‐Disubstitution and Their Application in Asymmetric Friedel—Crafts Alkylations.
Authors: O'Reilly Steven , Aylward Miriam , Keogh‐Hansen Caoimhe , Fitzpatrick Brian , McManus Helen A. , Mueller‐Bunz Helge , Guiry Patrick J.
Published: February 2016

High levels of enantioselectivities are obtained for the conversion of compound (I) with the C5 gem‐disubstituted ligand (BOX), whereas for the conversion of compound (IV) the best enantioselectivity is achieved with ligand (BXB).
ChemInform Abstract: Palladium‐Catalyzed Trimethylenemethane Cycloaddition of Olefins Activated by the σ‐Electron‐Withdrawing Trifluoromethyl Group.
Authors: Trost Barry M. , Debien Laurent
Published: February 2016

The presented method gives access to cyclopentanes bearing a quaternary stereocenter through a [3 + 2]‐cycloaddition reaction.
ChemInform Abstract: Oxidative Oxygen‐Nucleophilic Bromo‐Cyclization of Alkenyl Carbonyl Compounds Without Organic Wastes Using Alkali Metal Reagents in Green Solvent.
Authors: Moriyama Katsuhiko , Nishinohara Chihiro , Sugiue Toru , Togo Hideo
Published: February 2016

The title reaction proceeds via the oxidative umpolung of bromide using alkali metal bromide and an inorganic oxidant.
ChemInform Abstract: The First Report of Lewis Acid Reagents in the Intramolecular Rauhut—Currier Reaction.
Authors: Krasley Andrew T. , Malachowski William P.
Published: February 2016

Although not broadly applicable, the title reaction is exceptionally efficient with particular substrates.
ChemInform Abstract: Catalytic Arylsulfonyl Radical‐Triggered 1,5‐Enyne‐Bicyclizations and Hydrosulfonylation of α,β‐Conjugates.
Authors: Chen Zhen‐Zhen , Liu Shuai , Hao Wen‐Juan , Xu Ge , Wu Shuo , Miao Jiao‐Na , Jiang Bo , Wang Shu‐Liang , Tu Shu‐Jiang , Li Guigen
Published: February 2016

A catalytic bicyclization reaction of enynes with arylsulfonyl radicals generated in situ from sulfonyl hydrazides is established in the presence of TBAI and Cu(OAc)2 as catalysts.
ChemInform Abstract: Facile Rearrangements of a Vinylogous α‐Hydroxy‐β‐dicarbonyl Substrate Involving an Apparent Oxirane C—C Bond Scission.
Authors: Kucera Roman , Hylse Ondrej , Babiak Michal , Svenda Jakub
Published: February 2016

The base‐induced rearrangement of substrate (I) is believed to involve an oxirane intermediate.
ChemInform Abstract: Fragment Couplings via CO2 Extrusion—Recombination: Expansion of a Classic Bond‐Forming Strategy via Metallaphotoredox.
Authors: Le Chi Chip , MacMillan David W. C.
Published: February 2016

The metallaphotoredox‐catalyzed decarboxylation—recombination of in situ formed mixed anhydrides gives rise to a variety of ketones (III) and (VI) in moderate to high yields.
ChemInform Abstract: Synthesis of Hindered α‐Amino Carbonyls: Copper‐Catalyzed Radical Addition with Nitroso Compounds.
Authors: Fisher David J. , Burnett G. Leslie , Velasco Rocio , Read de Alaniz Javier
Published: February 2016

The Cu‐catalyzed radical addition between α‐bromocarbonyls and in situ‐generated nitroso compounds gives a wide range of α‐amino carbonyls under mild reaction conditions.
ChemInform Abstract: Direct gem‐Difluoromethylenation of sp3‐Hybridized Carbon Center Through Copper‐Mediated Radical/Radical Cross‐Coupling for the Construction of a CH2—CF2 Linkage.
Authors: Jiang Haizhen , Xu Minjun , Lu Wenjun , Tian Wenfeng , Wan Wen , Chen Yunrong , Deng Hongmei , Wu Shaoxiong , Hao Jian
Published: February 2016

The title reaction between various benzyl bromides and benzo‐1,3‐oxazolic difluoromethyl bromides tolerates various functional groups and proceeds in generally high yields.
ChemInform Abstract: N‐Difluoromethylthiophthalimide: A Shelf‐Stable, Electrophilic Reagent for Difluoromethylthiolation.
Authors: Zhu Dianhu , Gu Yang , Li Long , Shen Qilong
Published: February 2016

N‐Difluoromethylthiophthalimide (I) is prepared as the first storage‐stable difluoromethylthiolation reagent.
ChemInform Abstract: Direct Methylation of Amines with Carbon Dioxide and Molecular Hydrogen Using Supported Gold Catalysts.
Authors: Du Xian‐Long , Tang Gao , Bao Hong‐Liang , Jiang Zheng , Zhong Xin‐Hua , Su Dang Sheng , Wang Jian‐Qiang
Published: February 2016

The reductive methylation of cyclic amines (I) and (IV) as well as secondary amines (VI) with carbon dioxide proceeds readily in the presence of gold nanoparticles supported on γ‐alumina as a heterogeneous catalyst.
ChemInform Abstract: Ru(II)‐Catalyzed C—H Activation: Ketone‐Directed Novel 1,4‐Addition of ortho C—H Bond to Maleimides.
Authors: Bettadapur Kiran R. , Lanke Veeranjaneyulu , Prabhu Kandikere Ramaiah
Published: February 2016

Maleimides add to the ortho‐position of aryl ketones to furnish regioselectively the o‐(succinimid‐3‐yl)aryl ketones in good to high yields.
ChemInform Abstract: Nickel‐Catalyzed Reductive Coupling of Aryl Bromides with Tertiary Alkyl Halides.
Authors: Wang Xuan , Wang Shulin , Xue Weichao , Gong Hegui
Published: February 2016

Electron‐deficient aryl bromides react with tertiary alkyl bromides under mild conditions in the presence of pyridine or DMAP and imidazolium salts.
ChemInform Abstract: Application of Organoselenides in the Suzuki, Negishi, Sonogashira and Kumada Cross‐Coupling Reactions.
Authors: Stein A. L. , Bilheri F. N. , Zeni G.
Published: February 2016

Highly selective Pd‐catalyzed cross‐coupling reactions of organoselenides are reported.
ChemInform Abstract: Iridium(III)‐Catalyzed Direct Arylation of C—H Bonds with Diaryliodonium Salts.
Authors: Gao Pan , Guo Wei , Xue Jingjing , Zhao Yue , Yuan Yu , Xia Yuanzhi , Shi Zhuangzhi
Published: February 2016

A novel method for the direct arylation of sp2 and sp3 C—H bonds in ketoximes, nitrogen‐containing heterocycles, a wide range of arenes, and olefins is developed.
ChemInform Abstract: Asymmetric Hydroformylation of Heterocyclic Olefins Mediated by Supramolecularly Regulated Rhodium‐Bisphosphite Complexes.
Authors: Rovira Laura , Vaquero Monica , Vidal‐Ferran Anton
Published: February 2016

Rhodium complexes derived from conformationally transformable α,ω‐biphosphite ligands in combination with an alkali metal BARF‐salt as a regulation agent afford high regio‐ and/or enantioselectivities in asymmetric hydroformylation of vinyl compounds and heterocyclic olefins.
ChemInform Abstract: Practical and Economic Lithiations of Functionalized Arenes and Heteroarenes Using Cy2NLi in the Presence of Mg, Zn or La Halides in a Continuous Flow.
Authors: Becker Matthias R. , Ganiek Maximilian A. , Knochel Paul
Published: February 2016

The economic amide base lithium dicyclohexylamide (Cy2NLi) allows fast and convenient (40 s, 0 °C) in situ trapping flow metalations of a broad range of functionalized arenes, heteroarenes, and acrylate derivatives in the presence of various metal salts such as ZnCl2·2LiCl and MgCl2.
ChemInform Abstract: A General Synthetic Approach to para‐Cyclophanes via Ring‐Closing Metathesis.
Authors: Kotha Sambasivarao , Shirbhate Mukesh E.
Published: February 2016

A new method to synthesize para‐cyclophanes and longithorone C frameworks is reported involving alkylation, ceric ammonium nitrate oxidation and ring‐closing metathesis as key steps.
ChemInform Abstract: TBAF‐Triggered Aldol‐Type Addition of α‐Triethylsilyl‐α‐diazoacetone.
Authors: Abid Imen , Gosselin Pascal , Mathe‐Allainmat Monique , Abid Souhir , Dujardin Gilles , Gaulon‐Nourry Catherine
Published: February 2016

A Bu4NF induced aldol‐type reaction between α‐triethylsilyl‐α‐diazoacetone (I) with aldehydes gives the desilylated adducts (II) using 0.5 equiv.
ChemInform Abstract: A General, Practical Triethylborane‐Catalyzed Reduction of Carbonyl Functions to Alcohols.
Authors: Peng Dongjie , Zhang Mintao , Huang Zheng
Published: February 2016

The scalable method is efficiently applied to the reduction of esters, aldehydes, and ketones endowed with a very broad range of functional groups.
ChemInform Abstract: Catalytic Asymmetric Synthesis of Tertiary Alcohols and Oxetenes Bearing a Difluoromethyl Group.
Authors: Aikawa Kohsuke , Yoshida Seiya , Kondo Daisuke , Asai Yuya , Mikami Koichi
Published: February 2016

Highly enantioselective ene‐ and [2 + 2]‐cycloaddition reactions are developed starting from olefins or internal alkynes and halogenated pyruvates, respectively.
ChemInform Abstract: Copper‐Catalyzed Direct Transformation of Simple Alkynes to Alkenyl Nitriles via Aerobic Oxidative N‐Incorporation.
Authors: Huang Xiaoqiang , Li Xinyao , Jiao Ning
Published: February 2016

A novel direct transformation of aliphatic terminal alkynes to alkenyl nitriles through the incorporation of a nitrogen atom into the simple hydrocarbons is reported.
ChemInform Abstract: Copper‐Mediated Oxidative Trifluoromethylthiolation of Quinones.
Authors: Li Chao , Zhang Ke , Xu Xiu‐Hua , Qing Feng‐Ling
Published: February 2016

The title reaction provides an efficient access to novel trifluoromethylthiolated quinones.
ChemInform Abstract: Difluorocarbene‐Derived Trifluoromethylthiolation and [18F]Trifluoromethylthiolation of Aliphatic Electrophiles.
Authors: Zheng Jian , Wang Lu , Lin Jin‐Hong , Xiao Ji‐Chang , Liang Steven H.
Published: February 2016

The first trifluoromethylthiolation (and [18F]trifluoromethylthiolation) of alkyl electrophiles with in situ generated difluorocarbene in the presence of elemental sulfur and external (radioactive) fluoride ion is described.
ChemInform Abstract: Oxidatively Initiated NHC‐Catalyzed Enantioselective Synthesis of 3,4‐Disubstituted Cyclopentanones from Enals.
Authors: White Nicholas A. , Rovis Tomislav
Published: February 2016

A novel N‐heterocyclic carbene (NHC)‐catalyzed cycloaddition of α,β‐unsaturated aldehydes affords cyclopentanones via dimerization or cross‐reaction, respectively.
ChemInform Abstract: Synthesis of 7‐Norbornenols via Diels—Alder Cycloadditions of Cyclopentadienol Generated by Decomposition of Ferrocenium Cation.
Authors: Allen Stacey K. , Lathrop Thomas E. , Patel Sweta B. , Harrell Moody Deanna M. , Sommer Roger D. , Coombs Thomas C.
Published: February 2016

In situ generated cyclopentadienol is trapped via Diels—Alder reaction with various dienophiles to produce single diastereomers of norborneol derivatives.
ChemInform Abstract: Ligand‐Free Reusable Nano Copper Oxide‐Catalyzed Synthesis of 3‐Amino‐1,4‐diynes.
Authors: Mishra Subhajit , Santra Sougata , Hajra Alakananda
Published: February 2016

The new protocol is generally applicable to various aryl, alkyl, alkenyl, and heteroaryl alkynes.
ChemInform Abstract: One‐Carbon Homologation of Primary Alcohols and the Reductive Homologation of Aldehydes Involving a Jocic‐Type Reaction.
Authors: Li Zhexi , Gupta Manoj K. , Snowden Timothy S.
Published: February 2016

Various primary aryl, heteroaryl, aliphatic, alicyclic, and allylic alcohols are obtained in a simple two‐step, one‐carbon homologation of primary alcohols or reductive homologation of aldehydes using the Jocic‐type reaction of trichloromethyl carbinols as key reaction.
ChemInform Abstract: A Novel and Practical Asymmetric Synthesis of Dapoxetine Hydrochloride.
Authors: Zhu Yijun , Liu Zhenren , Li Hongyan , Ye Deyong , Zhou Weicheng
Published: February 2016

Dapoxetine hydrochloride (I) is stereoselectively synthesized in five linear steps from commercially available starting materials involving an introduction of the chiral auxiliary (S)‐tert‐butanesulfinamide.
ChemInform Abstract: 1,5‐Diketones Synthesis via Three‐Component Cascade Reaction.
Authors: Xing Li‐Juan , Lu Tao , Fu Wei‐Li , Lou Mei‐Mei , Chen Bo , Wang Zhi‐Shen , Jin Yang , Li Dan , Wang Bin
Published: February 2016

The new cascade synthesis of 1,5‐diketones from readily available N,N‐dicyclohexylmethylamine (III), 1,3‐dicarbonyl compounds, and trifluoromethyl β‐diketones occurs via an oxidation/Mannich reaction/Cope elimination/Michael addition/retro‐Claisen reaction sequence, and provides multiple C—C bond formations in one pot.
ChemInform Abstract: Reductive N—O Cleavage of Weinreb Amides by Sodium in Alumina and Silica Gels: Synthetic and Mechanistic Studies.
Authors: Jackson James E. , O'Brien Brittany N. , Kedzior Sonya K. , Fryz Gage R. , Jalloh Fatmata S. , Banisafar Arash , Caldwell Michael A. , Braun Max B. , Dunyak Bryan M. , Dye James L.
Published: February 2016

Sodium metal trapped in the nanoscale pores of alumina gel efficiently reduces Weinreb amides (I) in simple batch reaction mode.
ChemInform Abstract: Enantioselective Nickel‐Catalyzed Hydrocyanation Using Chiral Phosphine‐Phosphite Ligands: Recent Improvements and Insights.
Authors: Falk Anna , Cavalieri Alberto , Nichol Gary S. , Vogt Dieter , Schmalz Hans‐Guenther
Published: February 2016

This method allows Markovnikov‐like addition of HCN to vinylarenes in good to high yields and with excellent enantioselectivities.
ChemInform Abstract: Iridium‐Catalyzed ortho‐Arylation of Benzoic Acids with Arenediazonium Salts.
Authors: Huang Liangbin , Hackenberger Dagmar , Goossen Lukas J.
Published: February 2016

The COOH‐group in substituted benzoic acids is an efficient directing group for the regioselective ortho‐arylation with arenediazonium tetrafluoroborates in the presence of [IrCpCl*2]2 as the catalyst and Ag(I)‐salts as co‐catalysts.
ChemInform Abstract: A Four‐Component Reaction of Aryldiazonium Tetrafluoroborates, Sulfur Dioxide, 1,2‐Dibromoethane, and Hydrazines.
Authors: Zheng Danqing , Kuang Yunyan , Wu Jie
Published: February 2016

This novel approach to 2‐arylsulfonyl hydrazones (IV) and (VI) proceeds presumably via the N‐aminosulfonamide (VII) as intermediate.
ChemInform Abstract: Dimerization of Aryl Sulfonates by in situ Generated Nickel(0).
Authors: Maddaluno Jacques , Durandetti Muriel
Published: February 2016

O‐Tosylated phenol‐ and naphthol‐derivatives endowed with diverse functional groups are dimerized in high yields.
ChemInform Abstract: Organocatalytic Enantioselective Friedel—Crafts Alkylation of 1‐Naphthol Derivatives and Activated Phenols with Ethyl Trifluoropyruvate.
Authors: Montesinos‐Magraner Marc , Vila Carlos , Blay Gonzalo , Fernandez Isabel , Munoz M. Carmen , Pedro Jose R.
Published: February 2016

An organocatalytic enantioselective Friedel—Crafts alkylation of several 1‐naphthol derivatives with ethyl trifluoropyruvate is reported which is catalyzed by a quinine‐derived squaramide.
ChemInform Abstract: Directed Metalation—Suzuki—Miyaura Cross‐Coupling Strategies: Regioselective Synthesis of Hydroxylated 1‐Methyl‐phenanthrenes.
Authors: Joergensen Kaare B. , Rantanen Toni , Doerfler Thilo , Snieckus Victor
Published: February 2016

A directed ortho‐lithiation of 2‐(2‐methylphenyl)benzamides, obtained by Suzuki reactions (not shown) yields the corresponding 6‐substituted derivatives.
ChemInform Abstract: General Approach to Nitrogen‐Bridged Bicyclic Frameworks by Rh‐Catalyzed Formal Carbenoid Insertion into an Amide C—N Bond.
Authors: Harada Shingo , Kono Masato , Nozaki Tomoyuki , Menjo Yasuhiro , Nemoto Tetsuhiro , Hamada Yasumasa
Published: February 2016

The Rh‐catalyzed formal carbenoid insertion into an amide C—N bond delivers azabicyclo[X.Y.Z.]alkane derivatives in good to high yields and proceeds via the formation of Rh‐associated N‐ylides, followed by an acyl group‐selective Stevens [1,2]‐shift through a concerted addition/elimination process on the sp2‐hybridized carbon.
ChemInform Abstract: Catalytic Asymmetric Formal Synthesis of Beraprost.
Authors: Kobayashi Yusuke , Kuramoto Ryuta , Takemoto Yoshiji
Published: February 2016

The key intermediate (I) for the synthesis of beraprost is obtained in 14 steps involving an enantioselective organocatalyzed asymmetric intramolecular oxo‐Michael reaction of an unsaturated amide mediated by a newly developed benzothiadiazine catalyst.
ChemInform Abstract: Oxidative Cyclization of Tertiary Pentenol Derivatives Forming 2,5,5‐Trisubstituted THF Rings and the Total Synthesis of Cyclocapitelline.
Authors: Phillips Geoffrey A. , Palmer Cory , Stevens Andrew C. , Piotrowski Mathew L. , Dekruyf Daryl S. R. , Pagenkopf Brian L.
Published: February 2016

A modified Mukaiyama oxidative cyclization of homoallylic alcohols under aerobic conditions is developed using a pre‐oxidized cobalt complex as catalyst.
ChemInform Abstract: Diastereo‐ and Enantioselective Direct Vinylogous Michael Addition of γ‐Substituted Butenolides to 2‐Enoylpyridines Catalyzed by Chiral Bifunctional Amine‐Squaramides.
Authors: Wang Zhen‐Hua , Wu Zhi‐Jun , Huang Xue‐Qun , Yue Deng‐Feng , You Yong , Xu Xiao‐Ying , Zhang Xiao‐Mei , Yuan Wei‐Cheng
Published: February 2016

The reaction tolerates aryl, but no alkyl substituted butenolides and aryl, hetaryl, alkyl, and carboxyl‐substituted 2‐enoylpyridines.
ChemInform Abstract: Nitrative Cyclization of 1‐Ethynyl‐2‐(vinyloxy)benzenes to Access 1‐[2‐(Nitromethyl)benzofuran‐3‐yl] Ketones Through Dioxygen Activation.
Authors: Hu Ming , Liu Bang , Ouyang Xuan‐Hui , Song Ren‐Jie , Li Jin‐Heng
Published: February 2016

A novel, metal‐free method for title reaction using tBuONO, air, and water is presented giving the title compounds in good yields.
ChemInform Abstract: A Tandem Approach to Functionalized Carbazoles from Indoles via Two Successive Regioselective Oxidative Heck Reactions Followed by Thermal Electrocyclization.
Authors: Laha Joydev K. , Dayal Neetu
Published: February 2016

The synthesis of functionalized carbazoles is achieved via two successive oxidative Heck‐reactions, subsequent 6π‐electrocyclization, and oxidative aromatization.
ChemInform Abstract: anti‐Markovnikov Hydroheteroarylation of Unactivated Alkenes with Indoles, Pyrroles, Benzofurans, and Furans Catalyzed by a Nickel—N‐Heterocyclic Carbene System.
Authors: Schramm York , Takeuchi Makoto , Semba Kazuhiko , Nakao Yoshiaki , Hartwig John F.
Published: February 2016

The catalytic addition of C—H bonds at the C‐2 position of heteroarenes, such as pyrroles, indoles, benzofurans, and furans, is investigated.
ChemInform Abstract: Metal Free, I2‐Catalyzed [3 + 1 + 1] Cycloaddition Reactions to Synthesize 1,2,4‐Trisubstituted Imidazoles.
Authors: Tang Dong , Guo Xin , Wang Yu , Wang Jing , Li Jihui , Huang Qiangwei , Chen Baohua
Published: February 2016

An operationally simple and economical one‐pot procedure is developed for the three‐component reaction of α‐amino carbonyl compounds, aldehydes, and ammonium acetate to afford the title imidazoles.
ChemInform Abstract: New Access to Thioglycolurils by Condensation of 4,5‐Dihydroxyimidazolidin‐2‐ones(thiones) with HSCN.
Authors: Baranov Vladimir V. , Nelyubina Yulia V. , Kravchenko Angelina N. , Kolotyrkina Natalya G. , Biriukova Ksenia A.
Published: February 2016

The title process is especially useful for the synthesis of previously less accessible dithioglycolurils (V).
ChemInform Abstract: Selective Access to 4‐Substituted 2‐Aminothiazoles and 4‐Substituted 5‐Thiocyano‐2‐aminothiazoles from Vinyl Azides and Potassium Thiocyanate Switched by Palladium and Iron Catalysts.
Authors: Chen Binhui , Guo Shanshan , Guo Xiao , Zhang Guolin , Yu Yongping
Published: February 2016

The FeBr3‐promoted reaction does not work with ethyl 2‐azidoacrylate (IVd), 2‐azido‐N‐phenylallylamine (IVb) and 2‐azido‐1‐octene.
ChemInform Abstract: Multicomponent Reaction of Z‐Chlorooximes, Isocyanides, and Hydroxylamines as Hypernucleophilic Traps. A One‐Pot Route to Aminodioximes and Their Transformation into 5‐Amino‐1,2,4‐oxadiazoles by Mitsunobu—Beckmann Rearrangement.
Authors: Mercalli Valentina , Massarotti Alberto , Varese Monica , Giustiniano Mariateresa , Meneghetti Fiorella , Novellino Ettore , Tron Gian Cesare
Published: February 2016

A three‐component coupling reaction of Z‐chloro oximes, isocyanides, and hydroxylamine affords aminoglyoximes via [3+1] cycloaddition with preferential attack of isocyanides to nitrile N‐oxides.
ChemInform Abstract: Enantioselective Synthesis of Bicyclic δ‐Lactones via N‐Heterocyclic Carbene‐Catalyzed Cascade Reaction.
Authors: Liang Zhi‐Qin , Wang Dong‐Ling , Zhang Han‐Ming , Ye Song
Published: February 2016

The asymmetric reaction of cinnamylmethyl or cinnamylethyl malonates with aryl, hetaryl, alkenyl, or alkyl aldehydes delivers the title products containing three consecutive stereocenters in high yields, with excellent diastereoselectivities and very high enantioselectivities.
ChemInform Abstract: Catalytic Chemo‐, E/Z‐, and Enantioselective Cyclizations of o‐Hydroxybenzyl Alcohols with Dimedone‐Derived Enaminones.
Authors: Zhao Jia‐Jia , Zhang Yu‐Chen , Xu Meng‐Meng , Tang Man , Shi Feng
Published: February 2016

A highly E‐ and enantioselective cyclization of o‐hydroxybenzyl alcohols of type (I) and (IV) with dimedone derived enaminones is developed using a BINOL‐derived phosphonic acid as organocatalyst.