bluuebunny/crossref_metadata_2025 huggingface dataset:
FORMULASI DAN UJI SEDIAAN KRIM BODY SCRUB OATMEAL DAN YOGURT SEBAGAI ZAT AKTIF
Authors: Nur Rahmi Hidayati  , Sulistiorini Indriaty  , Yayan Rizikiyan  , Deni Firmansyah  , Nina Karlina  , Alya Najmatul Laila
Published: December 2023

Body scrub adalah sediaan farmasi dalam bentuk produk perawatan kulit berbutir kasar. Oatmeal dan yogurt dapat dimanfaatkan sebagai zat aktif pada sediaan body scrub, karena oatmeal kaya akan vitamin E yang dapat menyegarkan dan mengencangkan kulit. Sementara yogurt memiliki kandungan zat lactic acid dan alpha hydroxy acid yang dapat membantu mengangkat tumpukan sel kulit mati. Sehingga dibuat sediaan farmasi berupa krim body scrub dengan variasi konsentrasi yogurt 6%, 12% dan 18% serta oatmeal dengan konsentrasi 7,5%. Penelitian ini bertujuan untuk mengetahui formulasi dan uji sediaan body scrub. Pengujian mutu fisik dan kimia sediaan meliputi uji organoleptis, uji homogenitas, uji pH, uji daya sebar dan uji tipe emulsi. Hasil yang diperoleh menunjukkan bahwa formula I, formula II dan formula III memenuhi semua syarat evaluasi sediaan yang baik. Sehingga dapat disimpulkan bahwa yogurt dapat diformulasikan menjadi sediaan krim body scrub.
EVALUASI PENGGUNAAN ANTIBIOTIK DENGAN METODE ATC/DDD PADA PASIEN RAWAT INAP DI RUMAH SAKIT X KABUPATEN CIREBON
Authors: Uswatun Khasanah  , Tomi  , Kurniawati  , Aan Kunaedi  , Iin Indawati  , Lilis Listiyani  , Ayu Prihatini Nok Endang
Published: December 2023

ISPA merupakan suatu penyakit infeksi yang cukup serius karena menjadi suatu penyebab morbiditas dan mortalitas di Indonesia. Banyaknya penyebab terjadinya ISPA dan serta untuk menghindari terjadinya resistensi bakteri maka dari itu perlu dilakukan pemilihan dan penggunaan antibiotik yang tepat. Tujuan dari penelitian ini untuk mengetahui jenis antibiotik yang digunakan oleh pasien ISPA rawat inap Rumah Sakit X di Kabupaten Cirebon tahun 2020 dengan sistem klasifikasi Anatomical Theurapetic Chemical (ATC) dan pengukuran kuantitas dengan metode Defined Daily Dose (DDD). Pengambilan data secara retrospektif yang didapat dari data rekam medik pasien ISPA dengan jumlah sampel 73. Sampel yang digunakan adalah rekam medik pasien ISPA di Rumah Sakit X Kabupaten Cirebon. Dari hasil penelitian yang terdapat 10 jenis antibiotik yang digunakan untuk pengobatan ISPA di Rumah Sakit X Kabupaten Cirebon dimana tiga besarnya adalah Levofloxacin 143,2 DDD/100 patient-days, Moxifloxacin 100 DDD/100 patient-days, Ceftriaxon 93,6 DDD/100 patient-days.
The Effectiveness of E-Modules Through Physics Modeling Learning to Improve Problem Solving Skills
Authors: Arifuddin Muhammad , Syifa Linda Nur , Mahardika Andi Ichsan , Mastuang Mastuang
Published: December 2023

The use of conventional teaching materials with less innovative learning models results in a lack of problem solving skills possessed by students. This study aims to produce teaching materials in the form of vibration material e-modules through effective and feasible physics modeling learning to improve students' problem solving skills using the ADDIE development model. The subjects of the research were 34 class XI C students of SMAN 5 Banjarmasin. Data collection techniques using learning outcomes tests through pre-test and post-test. The results showed that the electronic module was stated to be very effective in terms of the average n-gain score for measuring problem solving skills of 0.78 in the high category. As well as there was a significant increase between before and after using the e-module through the paired sample t-test. Thus, the vibration material e-module through physics modeling learning is declared effective and significant in improving students' problem solving skills
Faktor Pendukung Dan Faktor Penghambat Pembelajaran Daring Sekolah Dasar Berbasis Whatsapp di Kelas III
Authors: Masum Mohammad
Published: December 2023

The background of this research is the curiosity of researchers about the Supporting Factors and Inhibiting Factors of Whatsapp-Based Online Learning in Theme 2 Class III SDN 009 Sungai Pagar, Kampar Kiri Hilir District, Kampar Regency, and how to provide solutions to the obstacles that arise in online learning. Online learning can be defined as an effort to connect students with learning resources that are physically separate or even far apart but can communicate, interact or collaborate directly and indirectly with each other. This research is a descriptive research using a qualitative approach to field research. The sampling technique used in this research is purposive sampling and snowball sampling while the data collection tools used are observation, interviews and documentation. The research results obtained in the form of whatsapp-based online learning support factors are; The internet/whatsapp can load and send various learning materials such as explanatory videos, picture messages, and voice messages, can communicate and give learning instructions at any time, students can follow learning from anywhere without having to go to school. The inhibiting factors for whatsapp-based online learning are; quota or data package that runs out quickly, signal is not good, also doesn't have an android cellphone. Based on the conclusions above, the researcher submits some suggestions as follows: For class III teachers at SDN 009 Sungai Pagar to reduce the assignments given to students so that assignments do not pile up or continue to give assignments but in small quantities, while students who do not or do not understand the teacher can make visits to students' homes either individually or in groups, For parents of students to be involved in supervising students during online learning because this plays an important role in the success of online learning, For schools to prepare teams of teachers who are on standby at school to help students who have difficulty in learning
Analyzing Nihal Yeğinobalı’s Moll Flanders Translation within the Interpretative Theory of Translation (ITT)
Authors: AKSOY ARIKAN Rabia
Published: December 2023

This study presents the Turkish translation of Daniel Defoe’s Moll Flanders by Nihal Yeğinobalı within the framework of the Interpretative Theory of Translation and Jean Delisle’s translation strategies. This article examines specific instances from the target text to explore the translation strategies used by Yeğinobalı, which exemplify the fundamental principles of interpretive theory. Within the scope of the research, a particular approach involved rephrasing the source text in a manner that aligned with the linguistic patterns and conventions prevalent in the target culture’s spoken discourse. Those mentioned above were taken after comprehending the intended significance of the message, achieved by eliminating the specific words and phrases used in the original text. The translator demonstrated the use of their linguistic and extralinguistic knowledge to uncover both the “explicit” and “implicit” significance rooted within the source text’s message. Next, they proceeded to reconstruct this comprehension within the target language context. The translator’s approach to translation is not limited to searching for linguistic equivalences but rather involves both linguistic and extralinguistic knowledge in the process. Instead of seeking precise correspondences between the source and target texts, this approach seeks contextual and textual counterparts. As a result, Delisle’s translation strategies displayed parallels with the techniques employed in every aspect of literary translation.
Guidelines for Greening Healthcare Spaces
Authors: Turki Wouroud , Bouaziz Amal , Hadj Taieb Amine , Gargouri Chema
Published: December 2023

Biophilic Design is a concept used in the interior design sector to increase the connection of users to the natural environment. Used at both the building and city level, this technique is claimed to have health, environmental, and economic benefits for space occupants and urban environments. The biophilic design focuses on human well-being to improve physical and mental health, performance, and wellness. All this opens the way to an understanding of the solutions that the use of biophilic design in healthcare spaces could bring. Indeed, through this research and based on the analysis of health spaces whose use of biophilic design has been ubiquitous, we will develop the notion of biophilic health care design and how this new way of space design will affect positively mental health, and subsequently, physical health of the person concerned by the health care in these health centers, hence its impact on the acceleration of healing. Upon concluding our comprehensive investigation into the prevalent application of biophilic design within healthcare settings, this study endeavors to provide a comprehensive set of directives tailored for designers. These guidelines are formulated to serve as a lucid roadmap, facilitating the seamless integration of biophilic principles into the architectural blueprint of hospitals. This undertaking is driven by the overarching objective of augmenting the favorable impacts on both mental and physical well-being, ultimately speeding up recuperation and instigating a revolutionary transformation in the domain of healthcare environments.
Effectiveness of a Social Networking Site Based Automatic Mobile Message Providing System on Glycemic Control in Patients with Type 2 Diabetes Mellitus
Authors: Kim Kyuho , Yun Jae-Seung , Lee Joonyub , Yang Yeoree , Lee Minhan , Ahn Yu-Bae , Cho Jae Hyoung , Ko Seung-Hyun
Published: December 2023

Background: This study investigated the effectiveness of a social networking site (SNS)-based automatic mobile message providing system on glycemic control in patients with type 2 diabetes mellitus (T2DM).Methods: A 3-month, randomized, open-label, controlled, parallel-group trial was conducted. One hundred and ten participants with T2DM were randomized to a mobile message system (MMS) (n=55) or control group (n=55). The MMS group received protocolbased automated messages two times per day for 10 weeks regarding diabetes self-management through KakaoTalk SNS messenger. The primary outcome was the difference in the change in glycated hemoglobin (HbA1c) levels (%) from baseline to week 12.Results: HbA1c levels were more markedly decreased in the MMS group (8.4%±0.7% to 8.0%±1.1%) than in the control group (8.5%±0.8% to 8.4%±0.8%), resulting in a significant between-group difference (P=0.027). No differences were observed in changes in fasting glucose levels, lipid profiles, and the number of participants who experienced hypoglycemia, or in changes in lifestyle behavior between groups. However, the self-monitoring of blood glucose frequency was significantly increased in the MMS group compared to the control group (P=0.003). In addition, sleep duration was increased in the MMS group, but was not changed in the control group.Conclusion: An SNS-based automatic mobile message providing system was effective in improving glycemic control in patients in T2DM. Studies which based on a more individualized protocol, and investigate longer beneficial effect and sustainability will be required in the future.
Effects of dietary probiotic Lactobacillus acidophilus and prebiotic Spirulina platensis on haemotological profile of Labeo rohita (Hamilton, 1822) fingerlings
Authors: D. Anni Jain Askwith Mary  , Azhagu Raj
Published: December 2023

Haematology is a crucial branch for assessing the quality of supplementary diets for fish. It provides information on fish health, environment, and disease and diet effects. Probiotics positively influenced hematological parameters like Hb, Hct, MCV and MCHC. This study investigated the effects of dietary supplementation with the probiotic Lactobacillus acidophilus and the prebiotic Spirulina platensis on hematological parameters in Labeo rohita fingerlings. L. rohita (5 ± 0.4 g) were divided into 12 treatment groups and one control group (0% supplement). The probiotic groups received 1-12% L. acidophilus (T1L-T6L). The prebiotic groups received 1-12% S. platensis (T1S-T6S). After 75 days, blood samples were analyzed for red blood cell count, hematocrit, hemoglobin, and hematological indices. Fish fed 12% L. acidophilus showed significantly higher hemoglobin and hematocrit compared to the 12% S. platensis group. Hematological parameters were significantly improved (P<0.05) with 12% L. acidophilus vs. 12% S. platensis. These results suggest that dietary supplementation with 12% L. acidophilus was more effective than 12% S. platensis for enhancing blood cell profile and health status in L. rohita fingerlings. Probiotic L. acidophilus may have greater benefits than prebiotic S. platensis for hematology in this fish species. The positive modulation of hematological parameters correlates with enhanced growth performance and health status in L. rohita observed in this study. Probiotic-prebiotic stimulated diets can be effectively utilized to improve health, immunity and productivity of L. rohita in aquaculture.
Identification and Phylogeny of potential bacteria isolated from mangroves of Ashtamudi Lake - A Ramsar site in peninsular India
Authors: Megha M  , John Sarlin , Jeniffer Ann Thomas  , Gayathry S
Published: December 2023

The tropical and subtropical coastal plains are known for harboring mangroves, which represent one of the most remarkable and distinctive ecosystems globally. These ecosystems are formed through the mutual interaction between emergent land plants and sediment microbiomes. The rhizosphere of mangroves and the adjacent sediments host a diverse range of microbial communities that play a crucial role in supporting vital ecological processes such as decomposition and nutrient recycling. Additionally, these microbial communities contribute to the nourishment and sustenance of mangrove vegetation. The objective of the present study was to investigate the bacterial diversity present in the mangrove sediments of Ashtamudi Lake, located in Kollam. This was accomplished through 16S rRNA sequencing, a widely employed technique for assessing microbial diversity. As a result, 16 potential strains of bacterial isolates belonging to genera such as Pseudomonas, Bacillus, Arthrobacter, Aeromonas, Oceanisphaera, and Mammalliicoccus were successfully identified. Furthermore, the evolutionary relationships among these bacterial strains were explored to gain insights into their genetic relatedness and phylogenetic classification.
Phytochemical Screening and Antimicrobial Activities of Leaves of Bombax ceiba L.
Authors: Supriya Kumari  , Surabhi Ambastha  , Amulya Kumari  , Dr. Amit Patnaik  , Dr. Latika Sharan
Published: December 2023

Bombax ceiba L. is a multi-purpose and fast-growing tree belonging to family Bombacaceae. It has astringent, diuretic, anti-diarrheal, etc. properties and also finds its uses in pharmacognosy. The leaves of B. ceiba L. have different phytochemicals like alkaloids, phenols, tannins, saponins, carbohydrates, etc. The leaves were used for phytochemical evaluation and its response against microbes. The extract for qualitative phytochemical analysis, prepared in distilled water, was done to test the existence of different phytochemicals like alkaloids, phenols, tannins, saponins, carbohydrates, etc. present in the leaves. Disc-diffusion method was employed to test the antimicrobial activity in different solvents like Dimethyl sulfoxide (DMSO), Ethanol and Water. Pseudomonas aeruginosa showed maximum zone of inhibition i.e. 25.33mm in the Ethanol extract, and minimum zone of inhibition was observed against Pseudomonas aeruginosa of 6.33mm in DMSO. These findings can help to understand the significance of the plant for preparation of medicine for some specific disease and can also be used to determine the effectiveness of the plant against certain micro-organisms.
Tüketici Güven Endeksi ile Finansal Yatırım Araçlarının Reel Getirileri Arasındaki Nedensellik İlişkilerinin Değerlendirilmesi: Türkiye Örneği
Authors: ŞEYRANLIOĞLU Onur
Published: December 2023

Bu araştırmada, Türkiye örnekleminde tüketici güven endeksi ile finansal yatırım araçlarının reel getirileri arasındaki ilişkilerin incelenmesi amaçlanmıştır. Mevduat, Dolar/TL, Euro/TL, BİST-100 pay endeksi, altın ve devlet iç borçlanma senetleri finansal yatırım araçları olarak kullanılmıştır. Aylık frekanslı verilerin kullanıldığı araştırma, 2005/01-2022/12 sürecini kapsamaktadır. Araştırmada ilişkilerin tespitinde Granger temelli Hacker ve Hatemi-J (2012) bootstrap nedensellik testi kullanılmıştır. Tüketici güven endeksinden tüm finansal yatırım araçlarının reel getirilerine doğru bir nedensellik söz konusu değilken; Dolar/TL, Euro/TL, BİST-100 pay endeksi, altın ve devlet iç borçlanma senetlerinin reel getirilerinden tüketici güven endeksine doğru tek yönlü nedensellik söz konusudur. Bulgular, yatırım araçlarına ilişkin öngörülerde tüketici güven endeksinin öncü bir gösterge olarak kullanılamayacağına işaret etmektedir.
An Analysis of Challenges Faced by Academics During the Transition from Contact to Online Learning
Authors: Mgoduka Siyasanga , Zwane Hloniphile Cleopatra
Published: December 2023

The Coronavirus (Covid-19) pandemic affected many lives and sectors across the world. In the higher education sector, Covid-19 caused a drastic shift from contact learning to multiple forms of online learning. It is in this context that the paper undertook a critical analysis of the challenges experienced by academics because of Covid-19. A comprehensive literature search was conducted on 6 databases (Google Scholar, ScienceDirect, Jstor, Academic Search Complete, SpringerLink, and SAGE Journals) for relevant studies published from the year 2019 to 2022. Moreover, further relevant studies were retrieved from the reference list of studies identified from the initial search. The search terms employed by the researchers were COVID-19, remote learning, e-learning, online learning, higher education, information technology and asynchronous learning systems. For the selection of the most relevant articles for the final review, the researchers employed inclusion and exclusion criteria. Studies that addressed higher education online learning and the challenges encountered by higher education due to Covid-19 were eligible for inclusion. The findings revealed that academics encountered multiple challenges during the transition from contact learning to online learning, these include the academic’s limited experience and lack of training in the pedagogy of online learning, challenges related to planning and adaptability, issues of network and connectivity, insufficient teaching and learning resources, workload, and stress along with the unconducive physical spaces and environment. Based on the findings presented, this study recommended that the pedagogical strategies must be revised. Furthermore, necessary adjustments in infrastructure in higher education institutions must also be made. This will ensure the smooth running of the teaching and learning process. Moreover, the systematic flaws and transformation gaps in higher education institutions have been made clear by the shift from contact learning to online learning. Thus, this study concludes that blended learning may emerge as the default teaching mode in higher learning institutions, this ensures the maximisation of efficiency.

Keywords: Covid-19, Online Teaching, Contact Or Face-To-Face Education, Higher Education, Technology.
Digital Transformation in South African Public Higher Education Institutions – A Pedagogical Approach
Authors: Gumede Philani , Beharry-Ramraj Andrisha , Nzimande Sindisiwe , Ramson Shakti M.
Published: December 2023

Traditional teaching and learning approaches were disrupted by COVID-19, which led to a considerable movement towards online and remote education, with public universities having to adapt to new remote learning methods and a delayed academic calendar. While these changes allowed for continued learning during the pandemic, they also came with challenges and had implications on student performance and well-being. This transition brought to light the necessity for effective pedagogical practices to engage students in virtual classrooms, which also exposed existing disparities in access to technology and internet connectivity. Studies have focused on student access and success in transformative digital learning by redressing socioeconomic issues. Keeping students engaged and connected to what is being delivered has yet to be explored in Public Higher Education Institutions (PHEIs). Numerous tools are available to engage and connect students during teaching and learning. However, these are not optimally utilised in PHEIs due to a lack of knowledge of their existence; lecturers’ preferences; lack of skills in using engaging tools; conventional teaching style that is assumed to be working; and lack of will to adapt and change with the times. Changing from conventional classrooms to hybrid and online classrooms requires changing teaching methods and especially pedagogies. This study aimed to identify how PHEIs could better benefit from using 21st-century pedagogies in virtual classrooms now that the pandemic is over. A qualitative research approach was used to gather data. A desktop literature review was used from a constructivist paradigm to assess and select data to include in the study methodologically. Data was analysed using theme analysis. This study found that blended learning and virtual learning have high propensity and knowledge retention rates amongst students, given that the pedagogies used by lecturers align with the new requirements of active and engaging learning. This study covered a broad aspect of pedagogies underpinning learning in 21st-century classrooms and theories. Recommendations were made for improved active engagement in the 21st-century classroom.

Keywords: Pedagogies, Covid19, Learning, Public Higher Education Institutions, Student Engagement
Critical Supply Chain Innovation Indicators that Enhance Business Performance: A Case Study of Weir Minerals Africa
Authors: Mabika Tazvivinga , Bhasela Yalezo
Published: December 2023

The principal link between technology and competitive advantage is innovation. The quest for sustainable competitive advantage has caused firms to invest in innovation, consequently, innovation is responsible for new industries coming into being, and it is innovation, which allows some firms to dominate in that space. Thus, this study aimed to examine the critical supply chain (SC) innovation indicators that enhance business performance. This research study centred on the operational activities of the Weir Minerals Africa (WMA) Isando facility in Johannesburg, South Africa, including all elements associated with the supply chain activities of the plant. The study sample of 230 respondents was considered representative of the population. The philosophical worldview in this research is positivism. Positivism hinges on computable observations that lead to statistical interpretations. The study was quantitative, adopted the deductive research approach, and a set of hypotheses were formulated for the research to confirm or reject a theory. For this population, the researcher applied a census-based sampling approach. The results showed that there is a significant number of indicators that enhance business performance and these include a clear culture of continuous improvement, focusing on new markets both locally and globally, product portfolio changes, constant connection and engagement with customers and cost structures. In light of these findings, the study provided a set of recommendations. Weir Minerals has a significant number of supply chain innovation hubs and metrics that include improvement and innovation culture across the entire organisation, an aggressive drive to create new markets and a clear posture to enforce standards and consistent value to its customers. However, it has not made a significant and noticeable effort to connect regularly with its customers. It has to improve on its customer relationship management frontier. The study findings underscored the relevance of a holistic overview of the supply chain problems at Weir Minerals Isando (WMI) that may inform the supply chain management decisions and expand academic knowledge.

Keywords: Supply Chain Innovation, Supply Chain Management, Sustainable Business Performance
These Visual Delights Have Sonic Ends
Authors: DOSSER MAX
Published: December 2023

Through the blending of the science fiction and western genres, the HBO seriesWestworldexplores issues of humanity and agency. These themes are not only played out through the series’ sprawling storylines; they are also encoded in the series’ title sequence. In this essay, I expand Leslie A. Hahner’s concept of affective prolepsis in visuals toaudiovisual prolepsisin order to illustrate how the paratextual title sequence visually and musically prepares the audience by encoding the series’ central philosophical questions of what it means to be alive and the role of agency in the conception of humanity. I argue the title sequence attunes the audience to these questions through a visual assembly of a body and a musical foreshadowing of a dance of agency and power struggles. Through considering audiovisual prolepsis, scholars are better able to understand how the intentions of media creators translate—successfully or unsuccessfully—to viewer experience and interpretation.
« Une petite révolution dans le monde agricole » : contribution à une philosophie politique des alternatives agro-écologiques
Authors: Delorme Damien
Published: December 2023

Les alternatives agro-écologiques sont des cas typiques de minorités actives qui luttent contre un modèle hégémonique, jugé insoutenable et destructeur au niveau environnemental et social. Elles constituent un terrain privilégié pour étudier, en philosophie politique, les rapports entre un centre hégémonique conservateur et des marges à l’avant-garde des transformations culturelles radicales. Dans une perspective de philosophie de terrain, cet article présente les résultats d’une enquête auprès d’une ferme biologique de maraîchage et de plantes aromatiques et médicinales, située en Haute-Savoie (France), adossée à une Association pour le maintien d’une agriculture paysanne. En mobilisant une analyse des potentialités révolutionnaires des pratiques minoritaires, l’article met en évidence les leviers d’influence et de transformation, et analyse les freins qui maintiennent ce modèle vertueux dans les marges d’un complexe agro-industriel destructeur des terres, des paysan·ne·s et de la santé collective.
Le rôle des conseillers et l’efficacité de l’aide des maisons de France Services dans l'adoption de démarches numériques de services publics
Authors: Leroux Erick , Pupion Pierre-Charles , Lancella Fabienne
Published: December 2023

Les plans de développement de l’e-administration incluent désormais un volet de lutte contre l’illectronisme et d’accompagnement des usagers dans leur démarche en ligne. Notre recherche analyse les effets et l’efficacité d’un dispositif d’accompagnement-aide en e-administration. Elle s’inscrit dans un nouveau courant de recherche qui identifie l’impact de l’aide sur les facteurs facilitateurs et inhibiteurs de l’usage d’une technologie. L’originalité du modèle tient à ce qu’il explique l’effet de l’organisation de l’aide sur l’appropriation des démarches en ligne. Il inclut les trois phases de l’adoption affectées par l’aide : acceptation a priori expliquant le recours aux maisons de France Services, effet de l’organisation de l’aide sur l’acceptation d’une technologie et enfin mesures de l’appropriation de la technologie ou dépendance à l’aide. Les résultats de l’étude réalisée par enquête auprès de 248 agents de France Services font apparaître l’effet de certains traits organisationnels qui affectent la facilité d’usage acquise et l’utilité perçue en agissant respectivement sur l’attitude des usagers face à la dématérialisation par les explications délivrées et par le succès de l’aide apportée. Ils révèlent de façon originale un comportement de dépendance à l’aide s’expliquant par l’anxiété et par la qualité du service rendu. Ces analyses sur l’action des maisons de France Services sont construites à partir des perceptions de leurs agents. En effet, le public qui sollicite cette aide est par essence en difficulté et n’a pas la capacité, en raison de l’effet dit de Kruger-Dunning, d’évaluer son autonomie et la qualité du service fourni.
Rôle d’un tiers-lieu, le « grin », dans la satisfaction-clients dans les garages automobiles informels de Bamako
Authors: Kamissoko Boubacar
Published: December 2023

« Grin », que l’on peut traduire par un lieu de causerie en langue Bambara, est un endroit au Mali où sont débattus des sujets d’actualité, des problèmes familiaux, des affaires entre amis voire entre prestataires de services et clients. Différent de la maison et du lieu de travail, le grin dispose de toutes les caractéristiques d’un tiers-lieu. Cependant, son rôle dans le rapprochement entre les prestataires de services et les clients est ignoré voire méconnu. Ce travail vise à comprendre le rôle du grin dans la satisfaction des clients des garages automobiles informels de la commune 6 de Bamako. Ainsi, nous avons effectué notre guide d’entretien auprès de 5 mécaniciens, 5 électriciens, 5 tôliers, 15 clients de 5 ateliers dont 3 choisis par atelier ainsi que 5 personnes différentes de ces catégories énumérées intervenant dans ce tiers-lieu. Pour ce faire, ces entretiens ont été analysés manuellement conformément à l’analyse thématique de Paillé et Muchielli. Les résultats montrent que le grin contribue positivement à la satisfaction relationnelle. L’étude relève l’importance des grins dans le processus de satisfaction dans les garages automobiles de la Commune 6 de Bamako.
Le secteur informel au Nigéria : une voie alternative pour la croissance économique
Authors: Omoloba Joseph , Bardot Rodolphe
Published: December 2023

Le secteur informel n’apporte pas seulement une contribution significative au Produit Intérieur Brut (PIB) de nombreux pays africains, mais aussi une source potentielle majeure au dynamisme entrepreneurial, en particulier pour ceux qui n’ont pas accès aux marchés et aux ressources productives pour rejoindre le secteur formel. L’objectif de cet article est de mener une réflexion sur le secteur informel en tant que facteur important de développement économique dans un pays comme le Nigéria. Pour combler le manque de recherche, nous avons développé un cadre théorique qui se concentre sur une matrice de décision concernant le niveau d’informalité. Cette étude est basée sur des échantillons de la population d’entrepreneurs et de propriétaires d’entreprises opérant de manière informelle dans différentes zones de marché à Lagos. Une méthode d’échantillonnage aléatoire a été utilisée pour classer les entrepreneurs informels en micro, petites et moyennes entreprises. Nous avons collecté un total de 120 questionnaires auprès des entrepreneurs qui ont participé ou qui opèrent dans le secteur informel depuis 2013. Les avantages de travailler dans cette industrie, y compris la relative liberté qu’elle offre aux entrepreneurs pour gérer leur entreprise, sont évidents. En outre, le secteur est un fournisseur essentiel de biens et de services pour les groupes sociaux à faible revenu. Les résultats de cette étude suggèrent que la productivité du secteur informel devrait être améliorée en proposant des politiques d’accompagnement.
Le brevet européen à effet unitaire
Authors: Ocvirk Philippe
Published: December 2023

Après dix ans, le paquet brevet unitaire est entré en vigueur le 1 er juin dernier ; c’est une révolution dans le domaine des brevets en Europe. Nouvel outil à la disposition des déposants à l’issue de la procédure de délivrance, le brevet européen à effet unitaire constitue une aubaine économique et amène une simplification administrative. Sa mise en œuvre se fait exclusivement devant la nouvelle Juridiction unifiée du brevet, permettant au titulaire de faire respecter ses droits à l’échelle pan-européenne. Il ne s’agit toutefois pas du « nouveau » brevet européen : il est optionnel, ne couvre qu’une partie de l’UE, présente un coût fixe qui ne convient pas à toutes les stratégies, et dépend d’une juridiction doit encore faire ses preuves.
Le droit à réparation des victimes d’un traitement illicite de données : les précisions apportées par la CJUE
Authors: Cachera Faustine , Wagner Astrid
Published: December 2023

Alors que le RGPD allait fêter ses cinq années d’application, la CJUE s’est positionnée pour la première fois sur la question du droit à réparation des victimes d’un traitement illicite de données dans un arrêt fort attendu des aficionados de la matière. Dans son arrêt du 4 mai 2023, la haute juridiction européenne apporte des précisions bienvenues du régime de responsabilité applicable en vertu du RGPD en exigeant la preuve d’un préjudice sans que ce dernier ne doive revêtir une certaine gravité tout en renvoyant au juge national la responsabilité de déterminer les modalités de réparation du préjudice subi par la victime en question.
Robotique à faible coût : métriques de la dissémination, usages malveillants et LAD
Authors: Berthier Thierry , de Boisboissel Gérard
Published: December 2023

La dissémination rapide de la robotique à faible coût est désormais une réalité opérationnelle. Il est aisé de se procurer des engins suffisamment performants et de les employer à des fins terroristes ou criminelles. Dès lors, il est urgent de déployer des capacités de lutte anti-drones avec des solutions innovantes et développées sans délais rédhibitoires.
La dronisation du soutien médical au combat
Authors: Queyriaux Benjamin
Published: December 2023

Au combat, l’absence de supériorité aérienne rend les évacuations médicales aériennes extrêmement difficiles : l’« heure d’or » devient le « soin prolongé aux blessés ». Les drones vont révolutionner cette approche grâce à des innovations technologiques et doctrinales. Couplé à la télémédecine et à l’intelligence artificielle, on peut imaginer des drones-cargos, des drones-ambulances voire des drones-robots médicaux.
Maîtriser l’information afin d’anticiper les conflits, les gagner, voire les éviter
Authors: Andriollo Margot
Published: December 2023

L’intelligence artificielle accélère le tempo de la guerre, en permettant le traitement de nombreuses données, leur exploitation puis l’appui à la décision. Le risque est de voir celle-ci échapper au filtre du chef militaire. Il convient donc d’établir les processus évitant ce travers, renforçant à la fois la place du chef et les bénéfices apportés par l’IA.
Les engagements des forces armées françaises. Des opérations extérieures au retour de la guerre en Europe
Authors: Lecoq Tristan
Published: December 2023

Nous assistons à la fin de la période engagée lors de la fin de la guerre froide. Trente ans après, la guerre est de retour et oblige à repenser celle-ci et à reconsidérer notre modèle militaire tourné jusqu’à présent autour des opérations extérieures (Opex). Il faut définir un nouveau contexte et un cadre d’emploi pour nos forces et en adapter les missions et surtout les moyens.
De l’initiative des pays du Champ à l’Alliance des États du Sahel :
Authors: Koungou Léon
Published: December 2023

Le Mali, le Burkina Faso et le Niger sont désormais gouvernés par des juntes militaires remettant en cause les relations notamment avec la France. Le repli sur soi de ces trois États ne se traduit pas par des succès sécuritaires. Bien au contraire, la situation s’est dégradée et ce n’est pas l’Alliance des États du Sahel conclue entre les putschistes qui résoudra la crise actuelle.
Optimal decision of a disaster relief network equilibrium model
Authors: Li Cunlin , Zhang Wenyu , Yee Hooi Min , Yang Baojun
Published: December 2023

Frequent natural disasters challenge relief network efficiency. This paper introduces a stochastic relief network with limited path capacity, develops an equilibrium model based on cumulative prospect theory, and formulates it as a stochastic variational inequality problem to enhance emergency response and resource allocation efficiency. Using the NCP function, Lagrange function, and random variables, the model dynamically monitors disasters, enabling rational resource allocation for quick decision-making. Compared to traditional methods, our model significantly improves resource scheduling and reduces disaster response costs. Through a random network example, we validate the model's effectiveness in aiding intelligent decision-making for relief plans and resource allocation optimization.
Knowledge graph completion method for hydraulic engineering coupled with spatial transformation and an attention mechanism
Authors: Liu Yang , Tao Tianran , Liu Xuemei , Tian Jiayun , Ren Zehong , Wang Yize , Wang Xingzhi , Gao Ying
Published: December 2023

In response to the limited capability of extracting semantic information in knowledge graph completion methods, we propose a model that combines spatial transformation and attention mechanisms (STAM) for knowledge graph embedding. Firstly, spatial transformation is applied to reorganize entity embeddings and relation embeddings, enabling increased interaction between entities and relations while preserving shallow information. Next, a two-dimensional convolutional neural network is utilized to extract complex latent information among entity relations. Simultaneously, a multi-scale channel attention mechanism is constructed to enhance the capture of local detailed features and global semantic features. Finally, the surface-level shallow information and latent information are fused to obtain feature embeddings with richer semantic expression. The link prediction results on the public datasets WN18RR, FB15K237 and Kinship demonstrate that STAM achieved improvements of 8.8%, 10.5% and 6.9% in the mean reciprocal rank (MRR) evaluation metric compared to ConvE, for the respective datasets. Furthermore, in the link prediction experiments on the hydraulic engineering dataset, STAM achieves better experimental results in terms of MRR, Hits@1, Hits@3 and Hits@10 evaluation metrics, demonstrating the effectiveness of the model in the task of hydraulic engineering knowledge graph completion.
IFN-β Pretreatment Alleviates Allogeneic Renal Tubular Epithelial Cell–Induced NK Cell Responses via the IRF7/HLA-E/NKG2A Axis
Authors: Zhang Xing , Wang Junni , Wang Mowang , Du Mengbao , Chen Jianghua , Wang Limengmeng , Wu Jianyong
Published: December 2023

Immune checkpoint molecules are promising targets for suppressing the immune response but have received little attention in immune tolerance induction in organ transplantation. In this study, we found that IFN-β could induce the expression of HLA-E as well as PD-L1 on human renal tubular epithelial cell line HK-2 and renal tissue of the C57BL/6 mouse. The JAK/STAT2 pathway was necessary for this process. Upregulation of both HLA-E and PD-L1 was fully abrogated by the JAK1/2 inhibitor ruxolitinib. Signaling pathway molecules, including STAT1, STAT2, mTOR, Tyk2, and p38 MAPK, were involved in HLA-E and PD-L1 upregulation. IRF7 is the key transcription factor responsible for the activation of HLA-E and PD-L1 promoters. Through screening an epigenetic regulation library, we found a natural compound, bisdemethoxycurcumin, enhanced IFN-β–induced HLA-E and PD-L1 expression in vitro and in vivo. In PBMC-derived CD56+ NK cells, we found that NKG2A but not PD1 was constitutively expressed, indicating HLA-E/NKG2A as a more potent target to induce tolerance to innate immune cells. Pretreating HK-2 cells by IFN-β significantly attenuated the degranulation of their coincubated NK cells and protected cells from NK-mediated lysis. In conclusion, IFN-β pretreatment could activate HLA-E and PD-L1 transcription through the JAK/STAT/IRF7 pathway and then could protect renal tubular epithelial cells from allogeneic immune attack mediated by NK cells.
Prevalence of positive “Pap” smears and psychological experience among post-natal women in a tertiary health center in Kano, Nigeria
Authors: Adamou Natalia , Aliyu Umar Usman , Datti Ahmed Zainad
Published: December 2023

Cervical cancer is a preventable and curable disease if diagnosed early, as it has a well-evaluated natural history. Cervical screening has been associated with a 74% reduction in the incidence of cervical cancer. The study aimed to evaluate the prevalence of abnormal “Pap tests” in post-natal patients and the psychological experience of patients undergoing “Pap tests”. This was a cross-sectional study. All newly registered post-natal patients who are sexually active and at least 3 years after sexual debut, from the age of 18 years and up to 49 years, and who gave consent were recruited for the study. One hundred and fifty-four (154) women, who completed six weeks post-partum, were recruited from October 1 to November 1, 2019. The majority of the patients were in the age group of 29-39 years, 75 (48.7%). The age ranged between 18 and 49 years, with a mean age of 34.24 years ± 6.957 SD. The mean age of marriage was 19.99 years ± 5.287 SD. The age of coitarche was 10-35 years, and 105 participants (68.18%) had their first sexual contact before the age of 20 years. The “pap” smear results were positive in 3 (1.95%) patients: Low-Grade Squamous Intraepithelial Lesion (LSIL) was found in 2 (1.30%), and High-Grade Squamous Intraepithelial Lesion (HSIL) in 1 (0.65%) patient. The prevalence of positive pap smears in post-natal patients was 1.9%. The majority of women were anxious, 78 (50.65%), and depressed, 88 (57.14%), prior to evaluation. However, no statistical association was found between risk factors, anxiety, and the number of positive smears in our sample group. A statistically significant difference was observed between anxiety and “Pap-test” by age, parity, and a statistically significant association by source of awareness in this study. Anxiety is the common reaction to any procedure, investigation or delivery of results. An abnormal response needs additional support, counseling, follow-up, and a clear explanation of the plan of management. Patients with high anxiety scores will benefit from multidisciplinary management.
Anti-inflammatory and anti-cancer potential of pterostilbene: A review
Authors: Surien Omchit , Masre Siti Fathiah , Basri Dayang Fredalina , Ghazali Ahmad Rohi
Published: December 2023

Pterostilbene is a natural compound that can be found in various food plants such as blueberries, grapes, and peanuts. It has also been reported to be extracted from Pterocarpus indicus, a tree species native to India and Southeast Asia. Pterostilbene exhibits various pharmacological activities such as antioxidants, anti-proliferation, anti-microbial, and anti-inflammatory activities with favorable pharmacokinetic properties, such as high oral bioavailability and longer half-life. The anti-inflammatory effect of pterostilbene has been reported to contribute to its therapeutic effects in many chronic inflammatory diseases. Besides, pterostilbene has anti-cancer activity on various types of cancers due to its ability to induce cell cycle arrest and apoptosis. Hence, in this review, we discuss the anti-inflammatory and anti-cancer activities of pterostilbene in preclinical studies.
Luteolin attenuates diabetic nephropathy via inhibition of metalloenzymes in rats
Authors: Daude R. B. , Bhadane Rajendra , Shah J. S.
Published: December 2023

Objective:

To investigate the renoprotective effects of luteolin on diabetes in rats.

Methods:

One week after administration of streptozotocin 55 mg/kg intraperitoneally, rats were given 25, 50, and 75 mg/kg/day of luteolin orally for another eight weeks. At the end of the experiment, body weight, blood glucose level, biochemical parameters for renal function (serum creatinine, blood urea nitrogen, uric acid, serum albumin, and total protein), kidney histology, matrix metalloproteinase (MMP)-2, MMP-9, and histone deacetylase 2 (HDAC-2) expression, and malondialdehyde, myeloperoxidase, and hydroxyproline content in renal tissue were evaluated. High glucose- induced damage using NRK-52E cell line was studied to evaluate cell viability and metalloenzyme expression. Additionally, in silico studies including docking and molecular dynamics simulations were conducted.

Results:

MMP-2, MMP-9, and HDAC-2 expressions were significantly increased in high glucose-induced NRK-52E cells and the renal tissue of diabetic rats. However, these changes were reversed by luteolin at the administered doses. Additionally, luteolin significantly reduced oxidative stress, inflammation, and fibrosis, as well as improved biochemical parameters in diabetic rats. Furthermore, luteolin at the examined doses markedly alleviated diabetes-induced histopathological changes in renal tissues.

Conclusions:

Luteolin effectively attenuates streptozotocin- induced diabetic nephropathy in rats by inhibiting MMP-2, MMP- 9, and HDAC-2 expression, and reducing oxidative stress and inflammation.
Macrophage-secreted exosomes inhibit breast cancer cell migration via the miR- 101-3p/DLG5 axis
Authors: Liu Yu , Wang Chao-Qun , Zhu Yong-Kang , Xu Jia-Fang , Yin Si-Qi , Hu Qing-Jie , Yang Rui-Qi
Published: December 2023

Objective:

To investigate the role of macrophages in regulating breast cancer cell migration and its related mechanisms.

Methods:

Human leukemia monocytic cell line THP-1-secreted exosomes were isolated using multi-step ultracentrifugation and verified using nanoparticle tracking analysis. Differentially expressed miRNAs were identified using RNA sequencing. Overexpression of inhibitors of hsa-miR-101-3p in breast cancer MDA-MB-231 cells was performed by infecting their lentiviral constructs. The luciferase reporter assay was used to evaluate the interaction of DLG5 and miR-101. DGL5 expression was detected using qRT-PCR and Western blot analyses.

Results:

The migration of breast cancer cells was significantly inhibited after addition of exosomes. RNA sequencing results showed that miR-101-3p expression was significantly upregulated. Targetscan analysis predicted that miR-101-3p could target DLG5, and this prediction was verified using the luciferase assay. The addition of the miR-101-3p precursor significantly increased the expression of miR-101-3p, and the mRNA and protein levels of DLG5 were suppressed. In contrast, inhibiting the expression of miR-101-3p increased the mRNA and protein levels of DLG5. Furthermore, the scratch assay showed that inhibiting miR-101-3p could promote the migration of MDA-MB-231 cells.

Conclusions:

Macrophage exosomes can inhibit the migration of breast cancer cells, and increasing the expression of miR-101-3p to inhibit DLG5 expression may play an important role in this process, which needs further investigation.