bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementing a Multi-Disciplinary, Evidence-Based Resilience Intervention for Moral Injury Syndrome: Systemic Barriers and Facilitators
Authors: Harris J. Irene , Dunlap Shawn , Xanthos Danielle , Pyne Jeffrey M. , Hermes Eric , Griffin Brandon J. , Kondrath Susannah Robb , Kim Se Yun , Golden Kristin B. , Cooney Nathaniel J. , Usset Timothy J.
Published: March 2024

Moral injury syndrome (MIS) is a mental health (MH) problem that substantially affects resilience; the presence of MIS reduces responsiveness to psychotherapy and increases suicide risk. Evidence-based treatment for MIS is available; however, it often goes untreated. This project uses principles of the Consolidated Framework for Implementation Research (CFIR) to assess barriers and facilitators to the implementation of Building Spiritual Strength (BSS), a multi-disciplinary treatment for MIS. Interviews were conducted with chaplains and mental health providers who had completed BSS facilitator training at six sites in the VA. Data were analyzed using the Hamilton Rapid Turnaround method. Findings included multiple facilitators to the implementation of BSS, including its accessibility and appeal to VA chaplains; leadership by VA chaplains trained in the intervention; and effective collaboration between the chaplains and mental health providers. Barriers to the implementation of BSS included challenges in engaging mental health providers and incorporating them as group leaders, veterans’ lack of familiarity with the group format of BSS, and the impact of the COVID-19 pandemic. Results highlight the need for increased trust and collaboration between VA chaplains and mental health providers in the implementation of BSS and treatment of MIS.
Exploring the Influence of YouTube on Digital Health Literacy and Health Exercise Intentions: The Role of Parasocial Relationships
Authors: Kim Jongho , Youm Heeok , Kim Sujin , Choi Hongjun , Kim Dohee , Shin Sungeun , Chung Jinwook
Published: March 2024

The purpose of this study was to analyze the mediating role of digital health literacy and the moderating effect of parasocial relationships on the relationship between the viewing experience of health exercise-related YouTube content and the intention for health exercise behavior. Based on the health action process approach, this study established a foundational theoretical model to analyze how digital health literacy mediates the impact of media viewing experience on health exercise behavior intention. Additionally, this study examined the moderating effect of parasocial relationships with YouTube creators. For empirical analysis, variables were measured using a self-administration method among 409 randomly sampled consumers of YouTube health exercise content. The collected data were analyzed using a structural equation model incorporating mediation parameters, and a multigroup model analysis was conducted to understand differences based on parasocial relationships. The results revealed that increased YouTube viewing experience enhanced cognitive, skill, and evaluative components of digital health literacy, which were significant factors in increasing health exercise behavior intention. Notably, the mediating effect of cognition played a crucial role, and the strengthening effect of parasocial relationships on this relationship was confirmed. These findings can be utilized as practical foundational data for designing digital health communication strategies, particularly in developing motivational mechanisms that encourage consumers to engage voluntarily and consistently in health behaviors based on online health information.
Links between Couples’ Cynical Hostility and Mental Health: A Dyadic Investigation of Older Couples
Authors: Segel-Karpas Dikla , Estlein Roi , Ermer Ashley E.
Published: March 2024

Whereas sharing a life with someone with high cynical hostility can be straining, little is known about how partner’s cynical hostility is associated with one’s mental health. In this paper, we report the findings from a longitudinal dyadic study using two waves of a large and representative American sample of older adults and their spouses to examine how one’s own and their spouse’s cynical hostility longitudinally affect anxiety and depressive symptoms. Results from APIM analyses suggest that both husbands’ and wives’ anxiety and depressive symptoms were negatively associated with their own cynical hostility, both within each time point and longitudinally. Partners’ cynical hostility, however, predicted only husbands’ mental health cross-sectionally. Furthermore, a moderating effect was identified, although it was not consistently observed across all analyses. Specifically, when a partner’s cynical hostility was high, the association between one’s own cynical hostility and their mental health was stronger, especially for women. Theoretical and practical implications are discussed.
Evolution of Project-Based Collaborative Networks for Implementing Prefabricated Construction Technology: Case Study in Shanghai
Authors: Liu Cong , Zeng Hui , Cao Jiming
Published: March 2024

Prefabricated construction (PC) is considered to be a low-carbon construction method. Implementing prefabricated construction projects (PCPs) requires multiple industry organizations to participate and collaborate. As different PCPs are initiated and implemented, industry organizations will gradually gather into a complex and evolving collaborative network at the industry level based on specific collaboration relationships with different project backgrounds. The evolution of the collaborative network is related to how industry organizations interact with each other, and how PC-related knowledge and innovation has spread among organizations in the long term. However, the laws of network evolution and the micro effects that drive network evolution are still unknown. This study analyzes 236 prefabricated construction projects (PCPs) in Shanghai during 2015–2023, using the stochastic actor-oriented models (SAOM) method to explore how the macro structure of project-based inter-organizational collaborative networks for prefabricated construction (PC) technology implementation evolves over time, and how micro effects jointly support the evolution of the networks. The macro-level descriptive analysis of the network indicates that the collaborative network has become increasingly dense over time and continues to show a core–peripheral structure, with a small number of super-connected organizations. The micro-level SAOM analysis further reveals that the evolution of the collaborative network structure is driven by structure-based preferential attachment and geographic proximity effects, as well as attribute-based ownership similarity effect. This exploratory effort applies a network dynamics model to investigate the micro mechanism of the evolution of inter-organizational collaboration. The research results provide theoretical guidance and decision-making references for PC industry organizations to develop efficient network action strategies. In addition, it can help industry managers to formulate appropriate network management strategies.
Basic Analysis of Physical Determinants Affecting the Distribution Density of Senior Citizen Centers around Small Apartment Complexes, Focusing on Administrative Districts in Busan
Authors: Zhao Xiaolong , Park Eun-soo , Kim Jieun , Lee Sang-Yup , Lee Heangwoo
Published: March 2024

The role of senior citizen centers is becoming more important, with a greater emphasis placed on ensuring that these establishments facilitate leisure and communication for older adults. These developments are taking place as population aging has now become an irreversible global trend. However, there is still a lack of systematic research on predicting the distribution density of senior citizen centers based on physical factors in urban planning. Therefore, this study set each administrative district in Busan as a unit and investigated physical factors affecting the distribution density of senior citizen centers around small apartment complexes to validate their effectiveness. First, the spatial hierarchy of each administrative district in Busan was examined. The city was divided into administrative districts while focusing on the distribution density of senior citizen centers (the dependent variable) around small apartment complexes where older adults live (within a 500 m radius). The spatial accessibility of senior citizen centers and the number of apartments in each administrative district were set as independent variables. This selection was made to verify the effectiveness of the physical factors by conducting an independent sample t-test, normality test, Friedman test, and two-way ANOVA. The chief findings of this study are as follows. (1) The spatial awareness of each administrative district was low, and there were large disparities in the land development density relative to the spatial scale of the administrative districts. (2) Regarding the physical factors affecting the distribution density of senior citizen centers, the spatial accessibility of senior residences was more significant than the number of small apartment complexes nearby. (3) Personal and social factors may have indirectly influenced the distribution density of senior citizen centers more than physical factors, depending on the type of house in which the older adults live. The findings will provide a theoretical basis for determining the location and distribution density of senior citizen centers in urban planning considering physical factors, as well as serve as a reference for public policy decisions related to the allocation of such centers in the future.
Characterization of CD34+ Cells from Patients with Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS) Using a t-Distributed Stochastic Neighbor Embedding (t-SNE) Protocol
Authors: Nollmann Cathrin , Moskorz Wiebke , Wimmenauer Christian , Jäger Paul S. , Cadeddu Ron P. , Timm Jörg , Heinzel Thomas , Haas Rainer
Published: March 2024

Using multi-color flow cytometry analysis, we studied the immunophenotypical differences between leukemic cells from patients with AML/MDS and hematopoietic stem and progenitor cells (HSPCs) from patients in complete remission (CR) following their successful treatment. The panel of markers included CD34, CD38, CD45RA, CD123 as representatives for a hierarchical hematopoietic stem and progenitor cell (HSPC) classification as well as programmed death ligand 1 (PD-L1). Rather than restricting the evaluation on a 2- or 3-dimensional analysis, we applied a t-distributed stochastic neighbor embedding (t-SNE) approach to obtain deeper insight and segregation between leukemic cells and normal HPSCs. For that purpose, we created a t-SNE map, which resulted in the visualization of 27 cell clusters based on their similarity concerning the composition and intensity of antigen expression. Two of these clusters were “leukemia-related” containing a great proportion of CD34+/CD38− hematopoietic stem cells (HSCs) or CD34+ cells with a strong co-expression of CD45RA/CD123, respectively. CD34+ cells within the latter cluster were also highly positive for PD-L1 reflecting their immunosuppressive capacity. Beyond this proof of principle study, the inclusion of additional markers will be helpful to refine the differentiation between normal HSPCs and leukemic cells, particularly in the context of minimal disease detection and antigen-targeted therapeutic interventions. Furthermore, we suggest a protocol for the assignment of new cell ensembles in quantitative terms, via a numerical value, the Pearson coefficient, based on a similarity comparison of the t-SNE pattern with a reference.
Results of a Randomized, Double-Blind, Placebo-Controlled, Phase 1b/2 Trial of Nabpaclitaxel + Gemcitabine ± Olaratumab in Treatment-Naïve Participants with Metastatic Pancreatic Cancer
Authors: Gardner Faithlore P. , Wainberg Zev A. , Fountzilas Christos , Bahary Nathan , Womack Mark S. , Macarulla Teresa , Garrido-Laguna Ignacio , Peterson Patrick M. , Borazanci Erkut , Johnson Melissa , Ceccarelli Matteo , Pelzer Uwe
Published: March 2024

The efficacy and safety of olaratumab plus nabpaclitaxel and gemcitabine in treatment-naïve participants with metastatic pancreatic ductal adenocarcinoma was evaluated. An initial phase 1b dose-escalation trial was conducted to determine the olaratumab dose for the phase 2 trial, a randomized, double-blind, placebo-controlled trial to compare overall survival (OS) in the olaratumab arm vs. placebo arms. In phase 1b, 22 participants received olaratumab at doses of 15 and 20 mg/kg with a fixed dose of nabpaclitaxel and gemcitabine. In phase 2, 159 participants were randomized to receive olaratumab 20 mg/kg in cycle 1 followed by 15 mg/kg in the subsequent cycles (n = 81) or the placebo (n = 78) on days 1, 8, and 15 of a 28-day cycle, plus nabpaclitaxel and gemcitabine. The primary objective of the trial was not met, with a median OS of 9.1 vs. 10.8 months (hazard ratio [HR] = 1.05; 95% confidence interval [CI]: 0.728, 1.527; p = 0.79) and the median progression-free survival (PFS) was 5.5 vs. 6.4 months (HR = 1.19; 95% CI: 0.806, 1.764; p = 0.38), in the olaratumab vs. placebo arms, respectively. The most common treatment-emergent adverse event of any grade across both arms was fatigue. Olaratumab plus chemotherapy failed to improve the OS or PFS in participants with metastatic PDAC. There were no new safety signals.
Blood-Based DNA Methylation Analysis by Multiplexed OBBPA-ddPCR to Verify Indications for Prostate Biopsies in Suspected Prostate Cancer Patients
Authors: Friedemann Markus , Jandeck Carsten , Tautz Lars , Gutewort Katharina , von Rein Lisa , Sukocheva Olga , Fuessel Susanne , Menschikowski Mario
Published: March 2024

Current prostate carcinoma (PCa) biomarkers, including total prostate-specific antigen (tPSA), have unsatisfactory diagnostic sensitivity and specificity resulting in overdiagnosis and overtreatment. Previously, we described an optimised bias-based preamplification–digital droplet PCR (OBBPA-ddPCR) technique, which detects tumour DNA in blood-derived cell-free DNA (cfDNA) of cancer patients. The current study investigated the performance of newly developed OBBPA-ddPCR-based biomarkers. Blood plasma samples from healthy individuals (n = 90, controls) and PCa (n = 39) and benign prostatic hyperplasia patients (BPH, n = 40) were analysed. PCa and BPH patients had tPSA values within a diagnostic grey area of 2–15 ng/mL, for whom further diagnostic validation is most crucial. Methylation levels of biomarkers RASSF1A, MIR129-2, NRIP3, and SOX8 were found significantly increased in PCa patients compared to controls. By combining classical PCa risk factors (percentage of free PSA compared to tPSA (QfPSA) and patient’s age) with cfDNA-based biomarkers, we developed PCa risk scores with improved sensitivity and specificity compared to established tPSA and QfPSA single-marker analyses. The diagnostic specificity was increased to 70% with 100% sensitivity for clinically significant PCa patients. Thus, prostate biopsies could be avoided for 28 out of 40 BPH patients. In conclusion, the newly developed risk scores may help to confirm the clinical decision and prevent unnecessary prostate biopsy.
Open versus Robot-Assisted Radical Cystectomy for the Treatment of pT4a Bladder Cancer: Comparison of Perioperative Outcomes
Authors: Perri Davide , Rocco Bernardo , Sighinolfi Maria Chiara , Bove Pierluigi , Pastore Antonio L. , Volpe Alessandro , Minervini Andrea , Antonelli Alessandro , Zaramella Stefano , Galfano Antonio , Cacciamani Giovanni E. , Celia Antonio , Dalpiaz Orietta , Crivellaro Simone , Greco Francesco , Pini Giovannalberto , Porreca Angelo , Pacchetti Andrea , Calcagnile Tommaso , Berti Lorenzo , Buizza Carlo , Mazzoleni Federica , Bozzini Giorgio
Published: March 2024

We compared the perioperative outcomes of open (ORC) vs. robot-assisted (RARC) radical cystectomy in the treatment of pT4a MIBC. In total, 212 patients underwent ORC (102 patients, Group A) vs. RARC (110 patients, Group B) for pT4a bladder cancer. Patients were prospectively followed and retrospectively reviewed. We assessed operative time, estimated blood loss (EBL), intraoperative and postoperative complications, length of stay, transfusion rate, and oncological outcomes. Preoperative features were comparable. The mean operative time was 232.8 vs. 189.2 min (p = 0.04), and mean EBL was 832.8 vs. 523.7 mL in Group A vs. B (p = 0.04). An intraoperative transfusion was performed in 32 (31.4%) vs. 11 (10.0%) cases during ORC vs. RARC (p = 0.03). The intraoperative complications rate was comparable. The mean length of stay was shorter after RARC (12.6 vs. 7.2 days, p = 0.02). Postoperative transfusions were performed in 36 (35.3%) vs. 13 (11.8%) cases (p = 0.03), and postoperative complications occurred in 37 (36.3%) vs. 29 (26.4%) patients in Groups A vs. B (p = 0.05). The positive surgical margin (PSM) rate was lower after RARC. No differences were recorded according to the oncological outcomes. ORC and RARC are feasible treatments for the management of pT4a bladder tumors. Minimally invasive surgery provides shorter operative time, bleeding, transfusion rate, postoperative complications, length of stay, and PSM rate.
The Role of Cytokines in Cutaneous T Cell Lymphoma: A Focus on the State of the Art and Possible Therapeutic Targets
Authors: Guglielmo Alba , Zengarini Corrado , Agostinelli Claudio , Motta Giovanna , Sabattini Elena , Pileri Alessandro
Published: March 2024

Cutaneous T cell lymphomas (CTCLs), encompassing mycosis fungoides (MF) and Sézary syndrome (SS), present a complex landscape influenced by cytokines and cellular responses. In this work, the intricate relationship between these inflammatory proteins and disease pathogenesis is examined, focusing on what is known at the clinical and therapeutic levels regarding the most well-known inflammatory mediators. An in-depth look is given to their possible alterations caused by novel immunomodulatory drugs and how they may alter disease progression. From this narrative review of the actual scientific landscape, Interferon-gamma (IFN-γ) emerges as a central player, demonstrating a dual role in both promoting and inhibiting cancer immunity, but the work navigates through all the major interleukins known in inflammatory environments. Immunotherapeutic perspectives are elucidated, highlighting the crucial role of the cutaneous microenvironment in shaping dysfunctional cell trafficking, antitumor immunity, and angiogenesis in MF, showcasing advancements in understanding and targeting the immune phenotype in CTCL. In summary, this manuscript aims to comprehensively explore the multifaceted aspects of CTCL, from the immunopathogenesis and cytokine dynamics centred around TNF-α and IFN-γ to evolving therapeutic modalities. Including all the major known and studied cytokines in this analysis broadens our understanding of the intricate interplay influencing CTCL, paving the way for improved management of this complex lymphoma.
Characteristics of Factors Influencing the Occurrence of Cleft Lip and/or Palate: A Case Analysis and Literature Review
Authors: Kulesa-Mrowiecka Małgorzata , Lipowicz Anna , Marszałek-Kruk Bożena Anna , Kania Damian , Wolański Wojciech , Myśliwiec Andrzej , Dowgierd Krzysztof
Published: March 2024

Introduction: Cleft lip with or without cleft palate (CL/P) stands as the most common congenital facial anomaly, stemming from multifactorial causes. Objective: Our study aimed to ascertain the prevalence and characteristics of cleft palates, identify associated risk factors to inform prevention and prenatal detection for early intervention, and assess postoperative rehabilitation protocols for cleft palates. Design: This study employs a retrospective descriptive and clinical approach. Patients: The study includes 103 children with cleft palates treated at the Department of Head and Neck Surgery Clinic for Children and Young Adults, Department of Clinical Pediatrics, University of Warmia and Mazury. Methods: We conducted a thorough evaluation of records, considering variables such as sex, cleft type, maternal occupation, parental education, and family history of clefts. Data analysis was carried out using R software version GPL-3 and ordinal logistic regression analyses. Results: Notably, children born to mothers who experienced significant stress during pregnancy exhibited a 9.4-fold increase in the odds of having bilateral cleft palates. Conversely, no substantial evidence was found to support the influence of the child’s sex, birth order, body mass, maternal exposure to workplace toxins, infections, or drug toxicity on the dependent variable. Conclusions: Our findings suggest that children with parents who have a history of clefts and those with less educated mothers are more likely to develop bilateral cleft palates. Additionally, children born to mothers experiencing stress during pregnancy face an increased risk of bilateral cleft palates. It is important to note that there is a paucity of literature on rehabilitation following various cleft palate surgical techniques in children.
Late Preterm Newborns: Breastfeeding and Complementary Feeding Practices
Authors: Dijokienė Ieva , Žemaitienė Raminta , Stonienė Dalia
Published: March 2024

Background: The aim of this study is to identify factors associated with successful breastfeeding in late preterm infants (LPIs) and explore the initiation of complementary feeding; Methods: Prospective cohort study was conducted of infants born at 34+0 to 36+6 weeks gestational age in the Hospital of the Lithuanian University of Health Sciences Kaunas Clinics during 2020–2021. Families were followed up until the infants reached 12 months of age. Average breastfeeding initial time, average breastfeeding duration time, prevalence of exclusive breastfeeding and average solid-food feeding initiation time were examined. The correlations among factors that might affect breastfeeding rates were calculated using the chi-square test (p < 0.05); Results: In our study with 222 eligible participants, we observed a statistically significant delay in breastfeeding initiation only in the 34+0+6 gestational age group (p < 0.001). At discharge, the 36+0+6 group exhibited a significantly higher exclusive breastfeeding rate (p < 0.001). Over the first year, breastfeeding rates varied, with no correlation found between duration of exclusive breastfeeding and gestational age. Initial solid-food feeding times were similar across groups, and all infants were introduced to vegetables first; Conclusions: Vaginal delivery, skin-to-skin contact after birth, early rooming-in, and breastfeeding within 2 h after birth statistically significantly causes earlier breastfeeding initiation and longer duration of breastfeeding in LPIs. All infants began solid-food feeding at an average age of 5 months, with vegetables being the primary food choice.
Review of the Modelling of Corrosion Processes and Lifetime Prediction for HLW/SF Containers—Part 1: Process Models
Authors: King Fraser , Kolàř Miroslav , Briggs Scott , Behazin Mehran , Keech Peter , Diomidis Nikitas
Published: March 2024

The disposal of high-level radioactive waste (HLW) and spent nuclear fuel (SF) presents a unique challenge for the prediction of the long-term performance of corrodible structures since HLW/SF containers are expected, in some cases, to have lifetimes of one million years or longer. Various empirical and deterministic models have been developed over the past 45 years for making predictions of long-term corrosion behaviour, including models for uniform and localised corrosion, environmentally assisted cracking, microbiologically influenced corrosion, and radiation-induced corrosion. More recently, fracture-mechanics-based approaches have been developed to account for joint mechanical–corrosion degradation modes. Regardless of whether empirical or deterministic models are used, it is essential to be able to demonstrate a thorough mechanistic understanding of the corrosion processes involved. In addition to process models focused on specific corrosion mechanisms, there is also a need for performance-assessment models as part of the overall demonstration of the safety of a deep geological repository. Performance-assessment models are discussed in Part 2 of this review.
The Influence of Nitrogen Partial Pressure on the Microstructure and Mechanical Properties of HfNbTaTiVZr High-Entropy Nitride Coating Deposited via Direct Current Cathodic Vacuum Arc Deposition
Authors: Krülle Tim , Kuczyk Martin , Leonhardt Michael , Zimmer Otmar , Leyens Christoph
Published: March 2024

In recent years, high-entropy alloys have attracted increasing scientific interest. Due to their promising combination of properties, such as high hardness and high temperature stability, they are attractive for use as tool coatings for machining applications, to give but one example. Previous studies often focused on layer deposition using magnetron sputtering. Comparatively little research has been carried out to date on coating deposition using direct current cathodic vacuum arc deposition (CAE), with higher achievable rates and almost completely ionized plasmas. The aim of this work is to investigate (HfNbTaTiZr)N-coatings produced by CAE. The nitrogen content was varied and the effects on the coating properties were investigated. Changing the N2/(N2 + Ar) ratio between 0.1 and 1.0 and varying the working pressure in the chamber from 2 Pa to 5 Pa resulted in variations of the nitrogen content of the coatings, ranging from 30 at% to 50 at%. Although different microstructures of the coatings were obtained, there was only a minor influence on the hardness and Young’s modulus.
Study on the Tip Leakage Loss Mechanism of a Compressor Cascade Using the Enhanced Delay Detached Eddy Simulation Method
Authors: Lin Shiyan , Li Ruiyu , Gao Limin
Published: March 2024

The leakage flow has a significant impact on the aerodynamic losses and efficiency of the compressor. This paper investigates the loss mechanism in the tip region based on a high-load cantilevered stator cascade. Firstly, a high-fidelity flow field structure was obtained based on the Enhanced Delay Detached Eddy Simulation (EDDES) method. Subsequently, the Liutex method was employed to study the vortex structures in the tip region. The results indicate the presence of a tip leakage vortex (TLV), passage vortex (PV), and induced vortex (IV) in the tip region. At i=4°,8°, the induced vortex interacts with the PV and low-energy fluid, forming a “three-shape” mixed vortex. Finally, a qualitative and quantitative analysis of the loss sources in the tip flow field was conducted based on the entropy generation rate, and the impact of the incidence on the losses was explored. The loss sources in the tip flow field included endwall loss, blade profile loss, wake loss, and secondary flow loss. At i=0°, the loss primarily originated from the endwall and blade profile, accounting for 40% and 39%, respectively. As the incidence increased, the absolute value of losses increased, and the proportion of loss caused by secondary flow significantly increased. At i=8°, the proportion of secondary flow loss reached 47%, indicating the most significant impact.
pRR30, pRR3.25% and Asymmetrical Entropy Descriptors in Atrial Fibrillation Detection
Authors: Biczuk Bartosz , Buś Szymon , Żurek Sebastian , Piskorski Jarosław , Guzik Przemysław
Published: March 2024

Background: Early detection of atrial fibrillation (AF) is essential to prevent stroke and other cardiac and embolic complications. We compared the diagnostic properties for AF detection of the percentage of successive RR interval differences greater than or equal to 30 ms or 3.25% of the previous RR interval (pRR30 and pRR3.25%, respectively), and asymmetric entropy descriptors of RR intervals. Previously, both pRR30 and pRR3.25% outperformed many other heart rate variability (HRV) parameters in distinguishing AF from sinus rhythm (SR) in 60 s electrocardiograms (ECGs). Methods: The 60 s segments with RR intervals were extracted from the publicly available Physionet Long-Term Atrial Fibrillation Database (84 recording, 24 h Holter ECG). There were 31,753 60 s segments of AF and 32,073 60 s segments of SR. The diagnostic properties of all parameters were analysed with receiver operator curve analysis, a confusion matrix and logistic regression. The best model with pRR30, pRR3.25% and total entropic features (H) had the largest area under the curve (AUC)—0.98 compared to 0.959 for pRR30—and 0.972 for pRR3.25%. However, the differences in AUC between pRR30 and pRR3.25% alone and the combined model were negligible from a practical point of view. Moreover, combining pRR30 and pRR3.25% with H significantly increased the number of false-negative cases by more than threefold. Conclusions: Asymmetric entropy has some potential in differentiating AF from SR in the 60 s RR interval time series, but the addition of these parameters does not seem to make a relevant difference compared to pRR30 and especially pRR3.25%.
Mechanism for High-Precision Control of Movement at Maximum Output in the Vertical Jump Task
Authors: Murakami Hiroki , Yamada Norimasa
Published: March 2024

Human movements are governed by a tradeoff between speed and accuracy. Previous studies that have investigated the tradeoff relationship in sports movements involving whole-body movements have been limited to examining the relationship from the perspective of competition-specific movements, and the findings on whether the relationship is valid have not been unified. Therefore, this study incorporated a vertical jump task with the introduction of a condition in which landing position control was added to evaluate the essence of a sports movement that requires both speed and accuracy. Accuracy was examined using a method that quantifies the coordinates of the landing and takeoff positions using entropy. The mechanism of that tradeoff was then examined by confirming the phenomenon and analyzing the 3D vector trajectories. An increase in accuracy and a decrease in speed were observed when the landing position was the control target, even in the vertical jumping task normally performed at maximum effort, and the 3D velocity vector was characterized by the following: a reduced scalar and a more vertical direction. While the entropy from the takeoff to the landing position seemed to decrease when the accuracy of the landing position improved, the following noteworthy results were obtained given the characteristics of the vertical jump. Unlike traditional feedback control in the entropy reduction in hand movements, the trajectory is predetermined in a feedforward-like manner by controlling the initial velocity vector at takeoff, which allows the landing point to be adjusted.
Drivers of S&P 500’s Profitability: Implications for Investment Strategy and Risk Management
Authors: Nagy Marek , Valaskova Katarina , Kovalova Erika , Macura Marcel
Published: March 2024

The financial markets, shaped by dynamic forces, including macroeconomic trends and technological advancements, are influenced by a multitude of factors impacting the S&P 500 stock index, a pivotal indicator in the US equity markets. This paper highlights the significance of understanding the exogenous variables affecting the index’s profitability for academics, portfolio managers, and investment professionals. Amid the global ramifications of the S&P 500, particularly in combating the eroding purchasing power caused by inflation, investing in stock indexes emerges as a means to safeguard wealth. The study employs various statistical techniques, emphasizing a methodical approach to uncover influential variables, and using static regression and autoregressive models for immediate and time-lagged effects. In conclusion, the findings have broad practical implications beyond investment strategy, extending to portfolio construction and risk management. Acknowledging inherent uncertainties in financial market forecasts, future research endeavors should target long-term trends, specific influences, and the impact of exchange rate fluctuations on index evolution. Collaboration across regulatory bodies, academia, and the financial industry is underscored, holding the potential for effective risk monitoring and bolstering overall economic and financial market stability. This research serves as a foundational step towards enhancing market understanding and facilitating more efficient investment decision-making approaches.
Enhancing Internal Control Mechanisms in Local Government Organizations: A Crucial Step towards Mitigating Corruption and Ensuring Economic Development
Authors: Boufounou Paraskevi , Eriotis Nikolaos , Kounadeas Theodoros , Argyropoulos Panagiotis , Poulopoulos John
Published: March 2024

Corruption poses a significant challenge to economic development and governance worldwide, with its detrimental effects permeating various levels of society. In the context of Greece, where corruption has been a longstanding issue, the role of internal audit mechanisms within local government organizations (LGOs) emerges as paramount. This paper presents a comprehensive analysis of the internal control landscape within LGO revenue departments, focusing on factors influencing its effectiveness and proposing strategies for improvement. Drawing upon survey data and regression analyses, this study highlights the crucial role of robust internal control mechanisms in combating corruption and fostering economic development. The findings underscore the importance of competent personnel, legislative compliance, interdepartmental collaboration, and technology utilization in enhancing internal control practices. Despite existing legislation, gaps in internal control implementation persist, including understaffing, inadequate procedures, and limited access to information. This study emphasizes the transformative potential of effective internal audit measures in mitigating corruption at the local level, thereby contributing to broader economic growth and societal well-being. Recommendations for strengthening the internal control structures within LGOs include the formal establishment of internal audit functions, adherence to professional standards, and the promotion of information system utilization. By addressing the corruption and inefficiencies within LGOs, this research underscores the pivotal role of institutional effectiveness in promoting transparency, accountability, and sustainable economic progress.
Modeling and Subjective Evaluation Method of Driveability for Fuel Cell Vehicles
Authors: Zhan Jun , Zhu Huainan , Duan Chunguang , Zhong Zhao-Hui , Huang Wei , Zhu Baoli , Xu Guangjian
Published: March 2024

Aiming at the demand for subjective evaluation of driveability for fuel cell vehicles, the modeling and evaluation method of driveability for fuel cell vehicles were studied in this paper. Firstly, a real-time model of the fuel cell vehicle powertrain system was established, which included the fuel cell model, power battery model, DC/DC converter model and drive motor model. Secondly, it was integrated with the vehicle dynamics model to form a virtual prototype of a fuel cell vehicle. And a virtual subjective evaluation platform for fuel cell vehicles was built by combining the virtual prototype and high-fidelity driving simulator. Thirdly, a subjective evaluation method of driveability for fuel cell vehicles was proposed, which included the starting performance, acceleration performance, uniform speed performance and tip-in/tip-out performance. Finally, the paper used the platform and method mentioned above to conduct subjective evaluations of the fuel cell vehicles.
Power Flow Regulation Effect and Parameter Design Method of Phase-Shifting Transformer
Authors: Jin Weigang , Liu Hangya , Zhang Weizhe , Yuan Jiaxin
Published: March 2024

In the context of carbon peaking and carbon neutrality goals, the integration of a large number of renewable energy sources may trigger significant tidal changes, leading to transmission congestion, wind and light abandonment, power oscillation, voltage and frequency fluctuations, etc. A phase-shifting transformer is a cost-effective and reliable power flow control equipment, but its key parameters lack systematic design methods. Based on the equivalent model of phase-shifting transformers, detailed design principles and methods have been proposed, and the configuration method of winding turns has been improved to facilitate calculation and control strategy formulation. The regulation effect of the phase-shifting transformer designed through simulation of power flow regulation in a typical 500 kV network is simulated. By adjusting the phase-shifting transformer, the power flow of heavy load lines can be transferred to light load lines, optimizing the power flow distribution and improving the transmission capacity of the cross-section.
Research on the Accounting and Prediction of Carbon Emission from Wave Energy Convertor Based on the Whole Lifecycle
Authors: Li Jian , Wang Xiangnan , Wang Huamei , Zhang Yuanfei , Zhang Cailin , Xu Hongrui , Wu Bijun
Published: March 2024

Wave energy, as a significant renewable and clean energy source with vast global reserves, exhibits no greenhouse gas or other pollution during real-sea operational conditions. However, throughout the entire lifecycle, wave energy convertors can produce additional CO2 emissions due to the use of raw materials and emissions during transportation. Based on laboratory test data from a wave energy convertor model, this study ensures consistency between the model and the actual sea-deployed wave energy convertors in terms of performance, materials, and geometric shapes using similarity criteria. Carbon emission factors from China, the European Union, Brazil, and Japan are selected to predict the carbon emissions of wave energy convertors in real-sea conditions. The research indicates: (1) The predicted carbon emission coefficient for unit electricity generation (EFco2) of wave energy is 0.008–0.057 kg CO2/kWh; when the traditional steel production mode is adopted, the EFco2 in this paper is 0.014–0.059 kg CO2/kWh, similar to existing research conclusions for the emission factor of CO2 for wave energy convertor (0.012–0.050 kg CO2/kWh). The predicted data on carbon emissions in the lifecycle of wave energy convertors aligns closely with actual operational data. (2) The main source of carbon emissions in the life cycle of a wave energy converter, excluding the recycling of manufacturing metal materials, is the manufacturing stage, which accounts for 90% of the total carbon emissions. When the recycling of manufacturing metal materials is considered, the carbon emissions in the manufacturing stage are reduced, and the carbon emissions in the transport stage are increased, from about 7% to about 20%. (3) Under the most ideal conditions, the carbon payback period for a wave energy convertor ranges from 0.28 to 2.06 years, and the carbon reduction during the design lifespan (20 years) varies from 238.33 t CO2 (minimum) to 261.80 t CO2 (maximum).
Adaptive Control of Quadrotors in Uncertain Environments
Authors: Leitão Daniel , Cunha Rita , Lemos João M.
Published: March 2024

The problem addressed in this article consists of the motion control of a quadrotor affected by model disturbances and uncertainties. In order to tackle model uncertainty, adaptive control based on reinforcement learning is used. The distinctive feature of this article, in comparison with other works on quadrotor control using reinforcement learning, is the exploration of the underlying optimal control problem in which a quadratic cost and a linear dynamics allow for an algorithm that runs in real time. Instead of identifying a plant model, adaptation is obtained by approximating the performance index given by the Q-function using directional forgetting recursive least squares that rely on a linear regressor built from quadratic functions of input/output data. The adaptive algorithm proposed is tested in simulation in a cascade control structure that drives a quadrotor. Simulations show the improvement in performance that results when the proposed algorithm is turned on.
Research on Blockchain Transaction Privacy Protection Methods Based on Deep Learning
Authors: Li Jun , Zhang Chenyang , Zhang Jianyi , Shao Yanhua
Published: March 2024

To address the challenge of balancing privacy protection with regulatory oversight in blockchain transactions, we propose a regulatable privacy protection scheme for blockchain transactions. Our scheme utilizes probabilistic public-key encryption to obscure the true identities of blockchain transaction participants. By integrating commitment schemes and zero-knowledge proof techniques with deep learning graph neural network technology, it provides privacy protection and regulatory analysis of blockchain transaction data. This approach not only prevents the leakage of sensitive transaction information, but also achieves regulatory capabilities at both macro and micro levels, ensuring the verification of the legality of transactions. By adopting an identity-based encryption system, regulatory bodies can conduct personalized supervision of blockchain transactions without storing users’ actual identities and key data, significantly reducing storage computation and key management burdens. Our scheme is independent of any particular consensus mechanism and can be applied to current blockchain technologies. Simulation experiments and complexity analysis demonstrate the practicality of the scheme.
Dichichthyidae, a New Family of Deepwater Sharks (Carcharhiniformes) from the Indo–West Pacific, with Description of a New Species
Authors: White William T. , Stewart Andrew L. , O’Neill Helen L. , Naylor Gavin J. P.
Published: March 2024

The genus Dichichthys was resurrected for five species previously allocated to the genus Parmaturus in the family Pentanchidae. Supraorbital crests on the chondrocranium distinguish Dichichthys from Parmaturus and other members of the family Pentanchidae. A new family, Dichichthyidae, has been proposed to contain Dichichthys. The sequence of the NADH2 mitochondrial gene confirms the placement of Dichichthys outside of the Pentanchidae family, as well as separate from the Atelomycteridae and Scyliorhinidae families. Dichichthys albimarginatus was described using a holotype collected off the coast of New Caledonia. A second juvenile specimen collected off the coast of Papua New Guinea was tentatively assigned as D. cf. albimarginatus. Dichichthys bigus is known from the holotype collected in the Coral Sea off the coast of Queensland, Australia. A new, parasite-afflicted underwater observation was reported further north of Queensland. The type species Dichichthys melanobranchus, previously only known from juvenile specimens, was redescribed based on adult specimens. Dichichthys nigripalatum is known from the holotype collected off Sumbawa, Indonesia, and a tentatively identified photo record from West Java. Dichichthys satoi n. sp. is described from the West Norfolk Ridge and off the North Island of New Zealand. Members of the genus Dichichthys have unique curved egg cases which have pliable ridges made up of numerous fibres and long coiled tendrils on the posterior end.
Influence of the Different Maturation Conditions of Cocoa Beans on the Chemical Profile of Craft Chocolates
Authors: do Carmo Mazzinghy Ana , Silva Viviane , Ramos Ana , de Oliveira Carla , de Oliveira Gabriel , Augusti Rodinei , de Araújo Raquel , Melo Júlio
Published: March 2024

Cocoa beans (Theobroma cacao L.) can be used for craft chocolate production, which arouses consumer interest due to their perceived better quality. This study aimed to evaluate the chemical profile of 80% artisanal chocolate samples produced with cocoa beans subjected to different maturation conditions. In the first maturation process, beans were matured under no-oxygen conditions, and in the second, the toasted beans were matured in oak barrels. The volatile compounds of the chocolate samples were extracted by the solid-phase microextraction method in headspace mode and analyzed by gas chromatography/mass spectrometer. The non-volatile compounds were extracted with methanol and analyzed through paper spray mass spectrometry. Overall, 35 volatile compounds belonging to different chemical classes (acids, alcohols, aldehydes, ketones, esters, and pyrazines) were identified, such as propanoic acid and butane-2,3-diol. In addition, 37 non-volatile compounds, such as procyanidin A pentoside and soyasaponin B, were listed. Tannins, flavonoids, and phenylpropanoids were the main chemical classes observed, varying between the two samples analyzed. Therefore, it was possible to verify that maturation conditions affected the metabolomic profile of the 80% artisanal chocolate samples, being able to influence the sensory characteristics and bioactive compounds profile. Given these results, the sensory evaluation of these chocolates is suggested as the next step.
Exploring the Nutritional and Bioactive Potential of Olive Leaf Residues: A Focus on Minerals and Polyphenols in the Context of Spain’s Olive Oil Production
Authors: Ronca Carolina L. , Duque-Soto Carmen , Samaniego-Sánchez Cristina , Morales-Hernández María Encarnación , Olalla-Herrera Manuel , Lozano-Sánchez Jesús , Giménez Martínez Rafael
Published: March 2024

Lyophilized plant-origin extracts are rich in highly potent antioxidant polyphenols. In order to incorporate them into food products, it is necessary to protect these phytochemicals from atmospheric factors such as heat, light, moisture, or pH, and to enhance their bioavailability due to their low solubility. To address these challenges, recent studies have focused on the development of encapsulation techniques for antioxidant compounds within polymeric structures. In this study, lyophilized olive leaf extracts were microencapsulated with the aim of overcoming the aforementioned challenges. The method used for the preparation of the studied microparticles involves external ionic gelation carried out within a water–oil (W/O) emulsion at room temperature. HPLC analysis demonstrates a high content of polyphenols, with 90% of the bioactive compounds encapsulated. Meanwhile, quantification by inductively coupled plasma optical emission spectroscopy (ICP-OES) reveals that the dried leaves, lyophilized extract, and microencapsulated form contain satisfactory levels of macro- and micro-minerals (calcium, potassium, sodium). The microencapsulation technique could be a novel strategy to harness the polyphenols and minerals of olive leaves, thus enriching food products and leveraging the antioxidant properties of the polyphenolic compounds found in the lyophilized extract.
Dirac Field, van der Waals Gas, Weyssenhoff Fluid, and Newton Particle
Authors: Fabbri Luca
Published: March 2024

This article considers the Dirac field in polar formulation and shows that when torsion is taken in effective approximation the theory has the thermodynamic properties of a van der Waals gas. It is then shown that in the limit of zero chiral angle the van der Waals gas reduces to a Weyssenhoff fluid, and in spinlessness regime the Weyssenhoff fluid further reduces to a Newton particle. This nesting of approximations allows us to interpret the various spinor quantities. We will see that torsion will provide a form of negative pressure, while the chiral angle will be related to a type of temperature.