bluuebunny/crossref_metadata_2025 huggingface dataset:
Technology for Blending Recombined Flour: Substitution of Extruded Rice Flour, Quantity of Addition, and Impact on Dough
Authors: Ren Xuyang , Zhang Huining , Lv Mingshou , Fan Hongchen , Liu Linlin , Wang Bing , Hu Xiaofeng , Shi Yanguo , Yang Chunhua , Chen Fenglian , Sun Ying
Published: September 2024

In a previous study, rice bread was prepared using a combination of rice–wheat mixed flour. To investigate the impact of the partial adoption of extruded rice flour (ERF) on mixed flour (MF) and mixed dough (MD), the effects of adding ERF on the pasting, mixing characteristics, texture, and water retention of the MF and MD were examined by a rapid visco analyzer (RVA), Mixolab, texture profile analysis (TPA), and a low-field nuclear magnetic resonance analyzer (LF-NMR). The PV, TV, BD, FV, and SV of the MF declined as the incorporated amount of ERF increased. There was no significant difference in the PT at the 5–15% addition level (p < 0.05), but it showed an increasing trend at the 20–30% level (p < 0.05). The incorporation of ERF led to a significant increase in the water absorption (WA) of the MD, while the DT, ST, C2, C3, C4, and C5 exhibited a declining trend. The texture analysis revealed a significant decrease in the dough hardness with the addition of ERF, with a 55% reduction in the hardness of the 30% improved mixed dough (IMD), and the cohesiveness increased significantly (p < 0.05). The IMD was mainly composed of weakly bound water. The content of weakly bound water increased with the ERF amount.
Plant Bioactive Compounds of Brazilian Pampa Biome Natural Grasslands Affecting Lamb Meat Quality
Authors: Jacondino Luiza , Poli Cesar , Tontini Jalise , Correa Gladis , da Silva Itubiara , Nigeliskii André , Mello Renius , Pereira Angélica , Magalhães Danielle , Trindade Marco , Carvalho Sandra , Muir James
Published: September 2024

Our study investigated how different levels of antioxidants and contrasting proportions of native legumes in the diet affect lamb meat quality. Twenty-four male Texel lambs were randomly assigned to three groups: two groups on a natural pasture in southern Brazil (Pampa Biome), each at a different proportion of legumes: Low-legume (LL, 4.37%) and High-legume (HL, 14.01%); the other group was stall-fed (Control) to achieve the same growth rates as the grazing groups. Cold carcass yield from the Control lambs was higher than HL. The meat from pasture-fed animals had a higher deposition of muscle α-tocopherol and lower lipid oxidation (TBARS values) after 9 days of storage. LL lambs had higher subcutaneous fat thickness, which promoted better sensory quality of the meat, as assessed by a trained panel. Pasture-based diets enhanced odd- and branched-chain fatty acids (OBCFAs), trans vaccenic acid, and total conjugated linoleic acids (CLAs), while decreasing elaidic acid. Despite the lower ∆9-desaturase activity, the higher proportion of Desmodium incanum (condensed tannin-rich native legume) in the HL diet did not impact meat nutritional quality. Finishing lambs on the Pampa Biome grasslands is an option for improving the oxidative stability and beneficial fatty acid content of lamb meat, which improves product quality and human consumer health.
Evaluation of Agronomic Traits, Total Phenolic Content, and Antioxidant Properties of Sesame Seeds of Different Colors and Origin
Authors: Osei Collins Yeboah , Lee Sookyeong , Lee Gi-An , Lee Sae Hyun , Yoo Eunae , Lee Jae-Eun , Kim Eun-Gyeong , Yang Tae-Jin
Published: September 2024

Rising health concerns regarding chronic diseases call for exploring natural sources of antioxidants and factors that influence their activity. This study evaluated the diversity of 112 sesame germplasms from Africa and Asia based on ten agronomic traits (seven quantitative and three qualitative), two antioxidant activities (ABTS and DPPH radical scavenging activities), and the content of one metabolite (TPC). TPC, DPPH, and ABTS were in the ranges of 4.98–87.88 µg GAE/mg DE, 3.97–46.23 µg AAE/mg DE, and 3.42–176.01 µg TE/mg DE, respectively. Statistical analyses revealed significant variations in agronomic traits, TPC, and antioxidant activities among the sesame germplasms (p < 0.05). Furthermore, the individual and interaction effects of seed color and the continent of origin on the levels of the quantitative traits, TPC, ABTS, and DPPH were analyzed, and the correlation among the traits was further evaluated. Diversity in TPC, ABTS, and DPPH was significantly associated with seed color and most of the quantitative agronomic traits (p < 0.05) but not with continent of origin. Principal component analysis revealed TPC, ABTS, DPPH, and five quantitative traits as the most discriminant traits. In general, six sesame accessions with high TPC and antioxidant activities (IT194356, IT170094, IT29971, IT185998, IT104246, and IT169623) as well as important agronomic traits were identified and, hence, could be used for developing improved sesame varieties.
The Integrated Analysis of miRNome and Degradome Sequencing Reveals the Regulatory Mechanisms of Seed Development and Oil Biosynthesis in Pecan (Carya illinoinensis)
Authors: Zhu Kaikai , Wei Lu , Ma Wenjuan , Zhao Juan , Chen Mengyun , Wei Guo , Liu Hui , Tan Pengpeng , Peng Fangren
Published: September 2024

Pecan seed oil is a valuable source of essential fatty acids and various bioactive compounds; however, the functions of microRNAs and their targets in oil biosynthesis during seed development are still unknown. Here, we found that the oil content increased rapidly in the three early stages in three cultivars, and that oleic acid was the predominant fatty acid component in the mature pecan embryos. We identified, analyzed, and validated the expression levels of miRNAs related to seed development and oil biosynthesis, as well as their potential target genes, using small RNA sequencing data from three stages (120, 135, and 150 days after flowering). During the seed development process, 365 known and 321 novel miRNAs were discovered. In total, 91 known and 181 novel miRNAs were found to be differentially expressed, and 633 target genes were further investigated. The expression trend analysis revealed that the 91 known miRNAs were classified into eight groups, approximately two-thirds of which were up-regulated, whereas most novel miRNAs were down-regulated. The qRT–PCR and degradome sequencing data were used to identify five miRNA- target pairs. Overall, our study provides valuable insights into the molecular regulation of oil biosynthesis in pecan seeds.
Curcumin-Loaded Liposomes in Gel Protect the Skin of Mice against Oxidative Stress from Photodamage Induced by UV Irradiation
Authors: Zhang Yongli , Sun Bin , Wang Lu , Shen Wang , Shen Si , Cheng Xiaoman , Liu Xuan , Xia Hongmei
Published: September 2024

Prolonged exposure to ultraviolet (UV) irradiation can cause oxidative stress in the skin, accompanied by rapid immunosuppressive effects, resulting in a peroxidation reaction throughout the body. Curcumin (Cur), as the bioactive compound of turmeric, is a natural polyphenol with potent antioxidant properties but is often overlooked due to its poor solubility and low bioavailability. In this study, curcumin-loaded liposomes in a sodium alginate gel complex preparation were designed to improve the bioavailability of curcumin and to study its preventive effect on photodamage. Cur-loaded liposomes (Cur-L), Cur-loaded gel (Cur-G) based on an alginate matrix, and curcumin-loaded liposomes in gel (Cur-LG) were prepared, and their antioxidant effects and drug diffusion abilities were evaluated. The antioxidant capacity of Cur, Cur-L, Cur-G, and Cur-LG was also studied in a mouse model of photodamage. Cur had the highest antioxidant activity at about 4 mg/mL. Cur-LG at this concentration showed antioxidant effects during 1,1-diphenyl-2-trinitrophenylhydrazine (DPPH) and H2O2 experiments. During the UV light damage test, Cur-LG demonstrated the ability to effectively neutralize free radicals generated as a result of lipid peroxidation in the skin, serum, and liver, thereby enhancing the overall activity of superoxide dismutase (SOD). In conclusion, using Cur-LG may protect against epidermal and cellular abnormalities induced by UV irradiation.
From Folklore to Proust: A Quest across Symbolic Universes
Authors: Vaz da Silva Francisco
Published: September 2024

This study explores the intersection of folklore and literature, specifically examining how a methodology developed for interpreting wondertales can be applied to a complex literary corpus, such as Marcel Proust’s À la recherche du temps perdu (In Search of Lost Time). The discussion proposes a case study for the use of allomotifs, or interchangeable motifs, to understand symbolic patterns in Proust’s literary work. The paper lays bare a widespread metaphorical field in wondertales, then follows its complications in the Proustian corpus. It suggests that Proust’s œuvre, much like folklore, operates within a symbolic universe where binary oppositions, such as good and evil or male and female, are fluid and dynamic. The discussion shows that Proust’s literary imagination aligns surprisingly well with the workings of folklore. This hybrid space of the imagination challenges conventional distinctions between folklore and literature, and brings to mind Lévi-Strauss’ erstwhile ruminations on the pensée sauvage.
The Role of Health Belief Model Constructs and Content Creator Characteristics in Social Media Engagement: Insights from COVID-19 Vaccine Tweets
Authors: Jia Xiaofeng , Ahn Soyeon , Seelig Michelle I. , Morgan Susan E.
Published: September 2024

Introduction: The Health Belief Model (HBM) has been widely studied, but it is unclear how social media post creators use HBM constructs to influence the public’s awareness of health topics, particularly for COVID-19 preventative health behaviors. Moreover, there is limited knowledge about how content creators enhance user engagement with COVID-19 vaccine tweets. Methods: A content analysis of COVID-19 vaccine tweets (n = 362) examined how HBM constructs were used in social media posts and their relationship to content creator characteristics (e.g., race, education level) and user engagement behaviors (e.g., number of favorites). Findings: Content creators’ tweets about COVID-19-related topics generally centered on two HBM constructs—benefits and barriers—while fewer tweets emphasized perceived susceptibility or self-efficacy; tweets containing these constructs were retweeted less often. Findings revealed that tweets from politicians, health experts, and white and Asian sources emphasized the perceived benefits of the COVID-19 vaccine. Individual tweets, especially from Black individuals and celebrities, generated more user engagement. Conclusions: Understanding the factors that contribute to social media user engagement with health-related content is important for designing more focused and impactful health communication campaigns and promoting healthier habits and perspectives. Thus, by demonstrating the possible relevance of the HBM to digital communication strategies or health campaigns, our study provides useful guidance for health promoters and policymakers who use social media to raise public health awareness.
Visualizing Hospital Management Data in R Shiny—A Case Study
Authors: Voellger Benjamin , Malesevic-Lepir Milica , Abdelrehim Mohamed A. Hafez , Bockelmann Dalibor
Published: September 2024

Objective: There is a demand to make hospital management information beyond basic key performance indicators (KPIs) accessible for clinicians. Methods: We developed an interactive application (IAPP) in R Shiny to visualize such information. We provided the IAPP source code online. As a use case, we recorded basic KPIs (numbers of patients (NPs), reimbursed valuation ratios (RVRs), mean length of stay (LOS)), main diagnoses (MDGNs), main procedures (MPRCs), and catchment area (CA) by district from April 2022 to March 2024 at the index department in central Germany, where a neurotrauma and spinal surgery service was resumed on 1 April 2022. Case mix indexes (CMIs) were calculated. We retrieved information about online-reported patient satisfaction (ORPS) from an online physician rating platform between January 2022 and March 2024. Information on longitudes and latitudes of the index department and neighbouring hospitals was collected. We calculated car travelling isochrones (CTIs) of the hospitals as a proxy variable for accessibility. Chi-square and Fisher’s exact served as statistical tests. Results: During the observation period, the monthly NPs increased from 26 to 43, the RVR showed a 3.96-fold increase, the CMI showed a 2.41-fold increase, and the LOS reached a steady state in the 2nd year after service resumption. CA (p = 0.03), MDGNs, and MPRCs diversified. ORPS trended towards better overall evaluation after service resumption (p = 0.09). CTI mapping identified a unique market position of the index department. Conclusions: The IAPP makes extended hospital management data accessible to clinicians, can inform other stakeholders in healthcare, and can be tailored to local conditions.
Demographic Data, Risk Factors, and Disease Burden of HS Patients in Lithuania at a Reference Center
Authors: Raudonis Tadas , Šakaitytė Austėja , Vileikis Tomas Petras , Černel Vitalij , Gancevičiene Rūta , Zouboulis Christos C.
Published: September 2024

Background: Hidradenitis suppurativa (HS) diagnosis often faces a global delay of 7.2 years due to factors like lack of recognition, stigma, and socioeconomic barriers. Limited effective therapies and frequent exacerbations impact patients’ quality of life, posing a significant burden on healthcare systems. Methods: HS patients were assessed according to European Hidradenitis Suppurativa Foundation (EHSF) Registry questionnaire guidelines at various stages of the disease and treatment. Results: The study included 49 patients; 57.14% (n = 28) of them were male. The average age of the subjects was 39.91 ± 13.665 years; the average BMI was 27.84 ± 7.362. A total of 59.18% (n = 29) were active or previous smokers. There were statistically more male smokers than female (p < 0.01). Average disease onset was 25.71 ± 13.743 years; the mean time to diagnosis was 5.2 ± 7.607 years. A total of 70.2% (n = 33) were previously misdiagnosed. Subjects had 6.17 ± 6.98 painful days over the preceding 4 weeks. The average intensity of pain according to the visual analogue scale (VAS) was 5.60 ± 3.36 points. The mean dermatology life quality index (DLQI) at baseline was 8.9 ± 7.436. Conclusions: The research revealed delayed diagnoses, especially for females. Smoking was linked to higher Hurley stages, with a prevalence among male smokers, and HS had a substantial impact on patients’ quality of life.
Examining Emotional and Physical Burden in Informal Saudi Caregivers: Links to Quality of Life and Social Support
Authors: Aloudiny Wejdan Homid , Alsaran Ftoon Fahad , Alessa Fawziah Muqbil , Almoayad Fatmah , Fiala Lamiaa
Published: September 2024

Background: Caregiver burden is an important issue for individuals who tend to be chronically ill, disabled or elderly family members. This burden affects caregivers around the world and can have a negative impact on their physical and mental health, ultimately reducing their quality of life. Methods: This study of informal adult caregivers in Saudi Arabia used a cross-sectional analytic design to explore the connections between caregiver burden, social support and quality of life. Data were collected using nonprobability convenience sampling through electronic questionnaires in Arabic. The Zarit Caregiver Burden Interview (ZBI-12), the Oslo Social Support Scale (OSSS-3) and the SF-12 Health Survey (short form of 12 questions) were used to assess caregiver burden, social support and quality of life, respectively. The relationships between these variables were analysed, and the statistical significance of the findings was reported. Results: The study revealed a connection between caregiver burden and both social support and quality of life. Caregivers with moderate to high burdens often had poor social support (60.52%) and a lower quality of life (72.47%). A statistically significant negative correlation between caregiver burden and quality of life (p < 0.05) indicated that caregivers with a higher burden had a lower quality of life. Similarly, a statistically significant negative correlation was found between social support and caregiver burden (p < 0.05), suggesting that caregivers with more social support experienced a lower burden. Conclusions: A higher caregiver burden is linked to a lower quality of life, especially when social support is inadequate. These findings highlight the need for targeted interventions to reduce caregiver burden by enhancing social support systems for caregivers and improving their quality of life. Recommendations include the development of community-based support programmes and policy changes to support informal caregivers.
Influence of Physical Activity, Physical Fitness, Age, Biological Maturity and Anthropometric Variables on the Probability of Suffering Lumbar, Neck and Shoulder Pain in Spanish Adolescents from the Region of Murcia
Authors: Albaladejo-Saura Mario , Mateo-Orcajada Adrián , Abenza-Cano Lucía , Vaquero-Cristóbal Raquel
Published: September 2024

Background: Back pain in adolescents is a common injury, mainly affecting the lumbar, cervical and sometimes shoulder region. This has been related to various factors, such as lifestyle habits or physical capacity, but no previous research has shown conclusive results. The aims of this study was to analyze the risk of suffering lumbar, neck and shoulder pain according to anthropometric and physical fitness variables, physical activity level, age and biological maturity in adolescents, as well as the influence of sex in the study results. Methods: A descriptive cross-sectional study was performed, including a sample of 2015 adolescents (boys: n = 1006, mean age = 14.41 ± 1.35 years-old; girls: n = 1009, mean age = 14.48 ± 1.41 years-old). The participants underwent an anthropometric evaluation and physical fitness tests were carried out, including a 20 m shuttle run, a counter movement jump, a horizontal jump, a 20 m sprint and push-up tests, followed by the completion of lumbar, neck and shoulder pain questionnaires. Results: Higher values in age and peak height velocity (PHV) showed an increase in the risk of suffering lumbar, neck and shoulder pain (OR = 0.79–1.55; p = 0.000–0.025). The anthropometric variables related to adiposity showed an increase in the risk of suffering back pain, with significant incidence in the lumbar region (OR = 1.32–1.60; p = 0.000); while muscle mass showed a protective effect (OR = 0.59; p = 0.000). Regarding the fitness tests, a better physical fitness seemed to protect adolescents from suffering from the analyzed back pains in the general sample and in the boys sample (OR = 0.56–1.60; p = 0.000), while in the girls sample the influence of the physical fitness was less relevant. Conclusions: Both anthropometry and physical fitness may influence the occurrence of back pain in adolescents, with some variations in their importance according to sex.
The Clinical and Psychopathological Profile of Inpatients with Eating Disorders: Comparing Vomiting, Laxative Abuse, and Combined Purging Behaviors
Authors: Panero Matteo , Bevione Francesco , Sottosanti Ilaria , Longo Paola , Toppino Federica , De Bacco Carlotta , Abbate-Daga Giovanni , Martini Matteo
Published: September 2024

Background/Objectives: The previous literature on purging behavior in eating disorders (EDs) suggests an overall more complicated clinical picture for individuals with this symptomatology. So far, no studies have analyzed the possible differences between the specific types of purging among ED inpatients. Methods: A clinical sample of 302 inpatients with EDs was classified according to no purging behaviors, vomiting, the abuse of laxatives, and both vomiting and the abuse of laxatives. Participants completed the following questionnaires: the Eating Disorder Examination Questionnaire (EDE-Q), Frost Multidimensional Perfectionism Scale (F-MPS), State–Trait Anxiety Inventory (STAI), and Beck Depression Inventory (BDI). Clinical information was collected for each individual. Results: Significant differences in the four groups were evidenced in age (p < 0.001), years of illness (p < 0.001), BMI at discharge (p < 0.001), STAI state anxiety (p < 0.001), STAI trait anxiety (p < 0.001), BDI (p < 0.001), EDE-Q eating concerns (p < 0.001), EDE-Q shape concerns (p < 0.001), EDE-Q weight concerns (p < 0.001), EDE-Q global score (p < 0.001), and F-MPS parental criticism (p < 0.001). ED inpatients with purging behaviors were older, had a longer duration of illness, higher parental criticism, and worse general and eating psychopathology. No differences emerged between the specific types of purging behavior. Conclusions: Purging behavior is a marker of severity in EDs independently of the specific type of purging. The appearance of any purging behavior must be regarded as a considerable red flag and be followed by an intensification of the cure.
Resilience as Safety Culture in German Emergency Medical Services: Examining Irritation and Burnout
Authors: Thielmann Beatrice , Ifferth Malwine , Böckelmann Irina
Published: September 2024

Background/Objectives: The stress levels in emergency services are enormous. The resulting stress can range from psychological irritation to burnout. This study examines the importance of resilience in the German EMS and its significance for the risk of irritation and burnout among EMS personnel. Methods: A quantitative cross-sectional online survey was conducted among 285 EMS personnel in Germany. Resilience was measured by the RS-13 Scale, irritation by the Irritation Scale (IS), and burnout by the Maslach Burnout Inventory (MBI). Sociodemographic and job-related data were also collected. A classification into resilient groups was used to compare stress levels. Results: More than one-third (39%) of the participants had a low level of resilience. EMS personnel with high levels of resilience had significantly lower scores on the cognitive and emotional irritation dimensions, as well as on the burnout dimensions of emotional exhaustion and cynicism. Conclusions: Resilience plays an important role in the safety culture of emergency services. The results support the hypothesis that high levels of resilience lead to less stress and help people cope better with stress. Almost two-fifths of the participants had lower resilience, underscoring the need for safe communication and targeted measures to strengthen resilience. Regular training, a supportive work environment, and promoting team cohesion and social support can improve emergency responders’ mental health and job performance. Future research should develop specific intervention strategies and evaluate their effectiveness to ensure the long-term health of emergency responders and improve the quality of emergency care.
A Cross-Sectional Study Exploring the Relationship between Work-Related, Lifestyle Factors and Non-Specific Neck and Shoulder Pain in a Southeast Asian Population
Authors: Lo Chi Ngai , Teo Victoria Yu En , Manaff Nur Farah Ain Binte Abdul , Seow Tessa Chu-Yu , Harve Karthik Subramhanya , Leung Bernard Pui Lam
Published: September 2024

Background and Objectives: Non-specific neck and shoulder pain (NSNSP) is prevalent among working adults. The increased use of electronic devices and prevalence of remote working and study following the COVID-19 pandemic have raised concerns about the potential rise in such conditions. This study aims to investigate the associations between work-related, lifestyle factors and NSNSP in the adult Southeast Asian Singaporean population. Materials and Methods: An online survey was administered electronically to Singaporeans aged 21 and above. Demographic data, NSNSP prevalence, computer and smartphone usage durations, sleep patterns, and exercise frequency were captured after obtaining informed consent (SIT institutional review board approval #2023014). Results: A total of 302 validated responses were recorded, including 212 suffering from NSNSP versus 90 in the comparison group. The NSNSP group showed significantly longer smartphone usage (5.37 ± 3.50 h/day) compared to the comparison group (4.46 ± 3.36 h/day, p = 0.04). Furthermore, the NSNSP group had lower exercise frequency (2.10 ± 1.74 days/week vs. 2.93 ± 2.21 days/week, p < 0.01) and shorter weekly exercise duration (2.69 ± 3.05 h/week vs. 4.11 ± 4.15 h/week, p < 0.01). The average NSNSP severity in this group was 34.9 ± 19.96 out of 100, correlating significantly with age (r = 0.201, p < 0.01) and BMI (r = 0.27, p < 0.01). Conclusions: This preliminary cross-sectional study examines characteristics of adult Southeast Asians with NSNSP post-COVID-19 pandemic. The findings indicate significantly longer smartphone use and less exercise in NSNSP respondents, with both age and body mass index (BMI) demonstrating significant correlations with NSNSP severity.
Protective Factors in the LGBTIQ+ Adolescent Experience: A Systematic Review
Authors: Ancín-Nicolás Ruth A. , Pastor Yolanda , López-Sáez Miguel Ángel , Platero Lucas
Published: September 2024

Background: LGBTIQ+ adolescents face multiple forms of violence due to minority stress, putting their mental health at risk. These adolescents, particularly trans and gender-diverse youth, face significant challenges, including family violence, bullying, and limited access to health services. This article investigates the factors that protect their mental health. Method: A systematic review of articles published between 2019 and 2024 was conducted using the PRISMA method. Results: The study identifies family and school support, peer relationships, and individual resilience as key protective factors to reduce depression, anxiety, and suicidal behavior, as well as increase self-esteem and well-being. Conclusions: This review calls for further research into protective factors related to the microsystem, exosystem, and macrosystem and the impact of intervention programs with adolescents and their families.
Objectively Measured Physical Activity and Sedentary Behaviour on Cardiovascular Risk and Health-Related Quality of Life in Adults: A Systematic Review
Authors: Santos Beatriz , Monteiro Diogo , Silva Fernanda M. , Flores Gonçalo , Bento Teresa , Duarte-Mendes Pedro
Published: September 2024

Background: This systematic review analysed the association between objectively measured physical activity and sedentary behaviour with cardiovascular risk and HRQoL in adults without previous CVD. Additionally, we analysed the impact of the intensity of the physical activity in this association. Methods: The search was carried out in three electronic databases with access until February 2023 to find studies with an observational design. For quality assessment, we used The National Institute of Health (NIH) Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. Results: We identified 5819 references, but only five studies were included. One study shows a positive association between physical activity and HRQoL, while sedentary behaviour was negatively related to HRQoL. Another study showed an association between high-intensity physical activity with a better physical component of HRQoL and low-intensity physical activity with a better mental component of HRQoL. Three studies concluded that higher levels of physical activity are associated with lower levels of cardiovascular risk and higher levels of sedentary behaviour are associated with higher levels of cardiovascular risk. Conclusion: Our findings suggested that people who spend more time being active and spend less time being sedentary appear to have lower cardiovascular risk and higher HRQoL.
Estimating Non-Stationary Extreme-Value Probability Distribution Shifts and Their Parameters Under Climate Change Using L-Moments and L-Moment Ratio Diagrams: A Case Study of Hydrologic Drought in the Goat River Near Creston, British Columbia
Authors: Dekker Isaac , Dubrawski Kristian , Jones Pearce , MacDonald Ryan
Published: September 2024

Here, we investigate the use of rolling-windowed L-moments (RWLMs) and L-moment ratio diagrams (LMRDs) combined with a Multiple Linear Regression (MLR) machine learning algorithm to model non-stationary low-flow hydrological extremes with the potential to simultaneously understand time-variant shape, scale, location, and probability distribution (PD) shifts under climate change. By employing LMRDs, we analyse changes in PDs and their parameters over time, identifying key environmental predictors such as lagged precipitation for September 5-day low-flows. Our findings indicate a significant relationship between total August precipitation L-moment ratios (LMRs) and September 5-day low-flow LMRs (τ2-Precipitation and τ2-Discharge: R2 = 0.675, p-values < 0.001; τ3-Precipitation and τ3-Discharge: R2 = 0.925, p-value for slope < 0.001, intercept not significant with p = 0.451, assuming α = 0.05 and a 31-year RWLM), which we later refine and use for prediction within our MLR algorithm. The methodology, applied to the Goat River near Creston, British Columbia, aids in understanding the implications of climate change on water resources, particularly for the yaqan nuʔkiy First Nation. We find that future low-flows under climate change will be outside the Natural Range of Variability (NROV) simulated from historical records (assuming a constant PD). This study provides insights that may help in adaptive water management strategies necessary to help preserve Indigenous cultural rights and practices and to help sustain fish and fish habitat into the future.
Managing Newborn Screening Repeat Collections for Sick and Preterm Neonates
Authors: Greaves Ronda F. , Northfield Jo-Ann , Cross Lauren , Mawad Nazha , Nguyen Thanh , Tan Maggie , O’Connell Michele A. , Pitt James
Published: September 2024

Some preterm and sick neonates have altered biochemical profiles and follow-up newborn screening (NBS) collections are recommended. The Victorian NBS program historically recommended repeat collections for babies with birth weight < 1500 g (managed by the maternity service provider) and 3 weeks post-transfusion (managed by the laboratory). We aimed to determine adherence to current guidelines and review the guidelines to improve NBS performance. To do this, we audited data from 348,584 babies between January 2018 and June 2022. Babies with a recorded birth weight of <1500 g were filtered for inclusion. For the overall review and visualization of the protocol, we sourced information from the literature, our professional society and tertiary hospital services. A total of 2647 babies had a birth weight recorded between 200 and 1499 g. Of these, 2036 (77%) had a second sample collected, indicating that >1 in 5 babies were not receiving a follow-up collection. Our timing of repeat collections for transfused babies, requiring a 3-week follow-up collection, was longer than in other Australasian jurisdictions. A new combined “sick–prem protocol” was launched to support repeat collections and after a 1-year review achieved 95% compliance. We recommend NBS laboratories audit preterm and sick neonate repeat collections to ensure appropriate follow-up. This should be supported with a visual process map to aid education and compliance.
The Enhancement of Statistical Literacy: A Cross-Institutional Study Using Data Analysis and Text Mining to Identify Statistical Issues in the Transition to University Education
Authors: de la Hoz-Ruiz Antonio , Howard Emma , Hijón-Neira Raquel
Published: September 2024

Statistics modules are included in most university degrees, independent of the degree area, and this means that many students face these modules underprepared and struggle because of a lack of statistics knowledge. The Maths Support Centre (MSC) in the University College Dublin (UCD) provides support for various mathematics-related subjects, with statistics students being the second-largest cohort of visitors. The overall goal of this paper is to identify the common statistical issues students face during the transition from secondary education to tertiary education. The main data set for this study is the data from UCD students who have accessed the UCD MSC since 2015/16 for statistics support; the categorization of statistical concepts has been made with the statistics module description for each statistics subject at the Universidad Rey Juan Carlos (URJC). First, we conducted a categorization of statistical concepts taught in university (based on URJC’s catergorization); after that, UCD MSC tutor comments were categorized and validated, and subsequently descriptive analyses and text mining were used on the UCD MSC comments to achieve a deeper understanding of the statistical issues. The statistical issues presented were categorized as descriptive statistics (22.8%), probability (44%), statistical inference (29.2%), and statistical software (4%). Students struggled with material that was introduced at university level rather than material seen at secondary level. Our findings on students’ main statistical issues contribute to the development of a suite of evidence-based educational applications and games to support undergraduate students internationally in first- and second-year statistical modules.
Research on Modification of Oxygen-Producing Adsorbents for High-Altitude and Low-Pressure Environments
Authors: Li Ye , Yue Huiqing , Zhang Quanli , Yan Dumin , Li Ziyi , Liu Zhiwei , Liu Yingshu , Wang Yongyan , Wang Shifeng , Yang Xiong
Published: September 2024

In oxygen production on plateaus, pressure swing adsorption (PSA) oxygen production is currently the most commonly used oxygen production method. In plateau regions, low pressure leads to a decrease in adsorbent nitrogen–oxygen separation performance, which affects the performance of PSA oxygen production, so it is particularly important to enhance adsorbent nitrogen–oxygen separation performance. In this paper, Li-LSX (lithium low-silicon aluminum X zeolite molecular sieve) adsorbents were modified using the liquid phase ion exchange method, and five kinds of modified adsorbents were obtained, namely AgLi-LSX, CaLi-LSX, ZnLi-LSX, CuLi-LSX, and FeLi-LSX, respectively. The influences of different metal ions and modification time lengths on the adsorbent nitrogen adsorption and nitrogen–oxygen separation coefficients were analyzed. Through theoretical calculations, the nitrogen and oxygen adsorption and separation performances of the modified adsorbents at different altitudes and low adsorption pressures were investigated. It is shown that the nitrogen adsorption capacity of the AgLi-LSX-1 adsorbent obtained from the modification experiment reaches 27.92 mL/g, which is 3.24 mL/g higher than that of Li-LSX; the nitrogen–oxygen separation coefficients of S1 and S2 are 19.24 and 7.54 higher, respectively; and the nitrogen–oxygen separation coefficients of S4 are 20.85 and 7.54 higher than those of Li-LSX, respectively. With the increase in altitude from 50 m to 5000 m, the nitrogen–oxygen separation coefficient of the AgLi-LSX-1 adsorbent increased rapidly from 20.85 to 57, and its nitrogen–oxygen separation coefficient S4 exceeded that of the Li-LSX adsorbent to reach 47.61 at an altitude of 4000 m. Therefore, the modified adsorbent AgLi-LSX-1 in this paper can enhance the performance of the PSA oxygen process for oxygen production in plateau applications.
Population Dynamics of the Mite Varroa destructor in Honey Bee (Apis mellifera) Colonies in a Temperate Semi-Arid Climate
Authors: Medina-Flores Carlos Aurelio , Saucedo Rojas Alejandro , Guzman-Novoa Ernesto , Alaniz Gutiérrez Luis
Published: September 2024

This study aimed to analyze the population dynamics of the mite Varroa destructor in honey bee (Apis mellifera) colonies in a temperate semi-arid climate in Mexico. Ten colonies homogeneous in population, food stores, and levels of mite infestation were used. The mite infestation rate in brood and adult bees, total number of mites, daily mite fall, brood and adult bee population, and food stores were determined periodically for 10 months. There was a significant effect (p < 0.05) of sampling period on the population of V. destructor in adult bees, brood, total mite population, and daily fallen mites. The total mite population increased by 26% on average per colony. The increase in brood amount reduced the mite infestation rate in adult bees, and the opposite occurred when the brood decreased. Monitoring V. destructor populations by recording fallen mites is more reliable than determining mite infestation rates in bees, as mite fall has a dynamic pattern similar to that of the total mite population. The best period to apply an acaricide treatment in the region of study is between November and December because most mites were in the phoretic phase, since there was less brood in the colonies compared to other times.
Full-Length Transcriptome Profiling of the Complete Mitochondrial Genome of Sericothrips houjii (Thysanoptera: Thripidae: Sericothripinae) Featuring Extensive Gene Rearrangement and Duplicated Control Regions
Authors: Liu Qiaoqiao , Xu Shiwen , He Jia , Cai Wanzhi , Wang Xingmin , Song Fan
Published: September 2024

The mitochondrial genome (mitogenome) of Thysanoptera has extensive gene rearrangement, and some species have repeatable control regions. To investigate the characteristics of the gene expression, transcription and post-transcriptional processes in such extensively gene-rearranged mitogenomes, we sequenced the mitogenome and mitochondrial transcriptome of Sericothrips houjii to analyze. The mitogenome was 14,965 bp in length and included two CRs contains 140 bp repeats between COIII-trnN (CR1) and trnT-trnP (CR2). Unlike the putative ancestral arrangement of insects, S. houjii exhibited only six conserved gene blocks encompassing 14 genes (trnL2-COII, trnD-trnK, ND2-trnW, ATP8-ATP6, ND5-trnH-ND4-ND4L and trnV-lrRNA). A quantitative transcription map showed the gene with the highest relative expression in the mitogenome was ND4-ND4L. Based on analyses of polycistronic transcripts, non-coding RNAs (ncRNAs) and antisense transcripts, we proposed a transcriptional model of this mitogenome. Both CRs contained the transcription initiation sites (TISs) and transcription termination sites (TTSs) of both strands, and an additional TIS for the majority strand (J-strand) was found within antisense lrRNA. The post-transcriptional cleavage processes followed the “tRNA punctuation” model. After the cleavage of transfer RNAs (tRNAs), COI and ND3 matured as bicistronic mRNA COI/ND3 due to the translocation of intervening tRNAs, and the 3′ untranslated region (UTR) remained in the mRNAs for COII, COIII, CYTB and ND5. Additionally, isoform RNAs of ND2, srRNA and lrRNA were identified. In summary, the relative mitochondrial gene expression levels, transcriptional model and post-transcriptional cleavage process of S. houjii are notably different from those insects with typical mitochondrial gene arrangements. In addition, the phylogenetic tree of Thripidae including S. houjii was reconstructed. Our study provides insights into the phylogenetic status of Sericothripinae and the transcriptional and post-transcriptional regulation processes of extensively gene-rearranged insect mitogenomes.
Effect of Co-Diet Supplementation on Biodegradation of Polyethylene by Galleria mellonella L. (Lepidoptera: Pyralidae)
Authors: Mahfooz Areej , Yasin Muhammad , Qayyum Mirza Abdul , Abbasi Asim , Hashem Abeer , Almutairi Khalid F. , Abd_Allah Elsayed Fathi , Farhan Muhammad , Aqueel Muhammad Anjum , Subhan Mishal
Published: September 2024

Pollution coming from plastic polymers, particularly polyethylene (PE), poses a serious threat to both humans and animals. The biodegradation of plastics facilitated by insects is a crucial and eco-friendly approach that can be employed to combat this global concern. Recently, the larvae of the greater wax moth Galleria mellonella (L.) have been recognized as avid ‘plastivores’. The current study was aimed at evaluating the feeding efficiency of G. mellonella larvae on PEs of various densities with a co-diet supplementation of wheat germ + honey and beeswax. The results reveal that maximum PE consumption (9.98 ± 1.25 mg) was recorded in the case of 1.0 mm thick PE after a 24 h interval; however, the same scenario also achieved the greatest reduction in larval weight (27.79 ± 2.02 mg). A significant reduction in PE mass (5.87 ± 1.44 mg) was also observed in 1.0 mm PE when fed beeswax; however, the larvae experienced minimal weight loss (9.59 ± 3.81 mg). The larvae exhibited a higher PE consumption in 1.0 mm PE, indicating that the lower the density of PE, the greater the consumed area. Moreover, the biodegradation levels were notably higher within the 24 h interval. In conclusion, these findings suggest that the density of PEs and the supplementation of the co-diet have an impact on PE biodegradation. Additionally, the utilization of G. mellonella for the biodegradation of PE proves effective when combined with beeswax, resulting in minimal weight loss of the larvae. Our findings offer initial insights into how Galleria mellonella larvae biodegrade polyethylene (PE) of four different densities, along with co-diet supplementation. This approach helps us evaluate how varying densities affect degradation rates and provides a better understanding of the larvae’s capabilities. Additionally, our observations at three specific time intervals (24, 48, and 72 h) allow us to identify the time required for achieving degradation rates. Through examining these time points, our method offers valuable insights into the initial phases of plastic consumption and biodegradation.
Open versus Minimally Invasive Partial Nephrectomy: Trends and Outcomes from a Wide National Population-Based Database
Authors: Franco Antonio , Lombardo Riccardo , Ditonno Francesco , Bologna Eugenio , Licari Leslie Claire , Nabulsi Omar , Ioos Darren , Gallo Giacomo , Tema Giorgia , Cicione Antonio , Nacchia Antonio , Tubaro Andrea , De Nunzio Cosimo , Cherullo Edward E. , Autorino Riccardo
Published: September 2024

Objectives: To investigate temporal trends and overall complication rates among open partial nephrectomy (OPN) and minimally invasive partial nephrectomy (MIPN), including the impact of social determinants of health (SDOH) on postoperative outcomes. Methods: Patients who underwent OPN or MIPN between 2011 and 2021 were retrospectively analyzed by using PearlDiver-Mariner, an all-payer insurance claims database. The International Classification of Diseases diagnosis and procedure codes were used to identify the type of surgical operation, patient’s characteristics (age, sex, region, insurance plan), postoperative complications and SDOH, categorized in education, healthcare, environmental, social, and economic domains. Outcomes were compared using multivariable regression models. Results: Overall, 65,325 patients underwent OPN (n = 23,377) or MIPN (n = 41,948). OPN adoption declined over the study period, whereas that of MIPN increased from 24% to 34% (p = 0.001). The 60-day postoperative complication rate was 15% for the open and 9% for the minimally invasive approach. Approximately 16% and 11% of patients reported at least one SDOH at baseline for OPN and MIPN, respectively. SDOH were associated with higher odds of postoperative complications (OPN = OR: 1.11, 95% CI: 1.01–1.25; MIPN = OR: 1.31, 95% CI: 1.18–1.46). The open approach showed a significantly higher risk of postoperative complications (OR: 1.62, 95% CI: 1.54–1.70) compared to the minimally invasive one. Conclusions: Our findings confirm that MIPN is gradually replacing OPN, which carries a higher risk of complications. SDOH are significant predictors of postoperative complications following PN, regardless of the approach.
Management of Mandibular Condyle Fractures in Pediatric Patients: A Multicentric Retrospective Study with 180 Children and Adolescents
Authors: Bottini Gian Battista , Hitzl Wolfgang , Götzinger Maximilian , Politis Constantinus , Dubron Kathia , Kordić Mario , Sivrić Anamaria , Pechalova Petia , Sapundzhiev Angel , Pereira-Filho Valfrido Antonio , de Oliveira Gorla Luis Fernando , Dediol Emil , Kos Boris , Rahman Tabishur , Rahman Sajjad Abdur , Samieirad Sahand , Aladelusi Timothy , Konstantinovic Vitomir S. , Lazić Marko , Vesnaver Aleš , Birk Anže , Sohal Karpal Singh , Laverick Sean , Rae Euan , Rossi Maria Beatrice , Roccia Fabio , Sobrero Federica
Published: September 2024

Background: Mandibular condyle fractures in pediatric patients can lead to crippling sequelae such as ankylosis, pain and facial deformity if not managed properly. However, there is no consensus on the best approach for treating these fractures in children. Objective: This study aimed to describe the management of mandibular condyle fractures in growing patients across 14 maxillofacial departments worldwide. Methods: A retrospective multicenter study was conducted on children and adolescents aged 0 to 16 who had at least one mandibular condyle fracture. This study included patients who underwent expectant, closed, or open management and were treated over an 11-year period. Results: 180 patients had at least one mandibular condyle fracture, and 37 had a second condylar fracture. One hundred sixteen patients (65%) were males, and 64 (35%) were females (ratio 1.8:1). An expectant strategy was chosen in 51 (28%) patients, a closed treatment—stand-alone maxillomandibular fixation (MMF)—in 47 (26%), and open reduction and internal fixation (ORIF) was performed in 82 (46%) patients. The management varied significantly between the different departments (p < 0.0001). Significant differences were also identified between the fracture type (non-displaced, displaced or comminuted) and the management of the 180 patients with a single condylar fracture. Out of 50 non-displaced fractures, only 3 (6%) had ORIF, 25 (50%) had expectant management, and 22 (44%) had MMF. Out of 129 displaced fractures, 79 (62%) had ORIF, 25 (19%) had a soft diet, and 25 (19%) had MMF. Conclusions: Expectative management, MMF, and ORIF were all effective in treating pediatric mandibular condyle fractures, with a low incidence of complications and asymmetry.
The Analysis of Neutrophil to Lymphocyte Ratio (NLR), Lymphocyte to Monocyte Ratio (LMR), and Platelet to Lymphocyte Ratio (PLR) in Patients with Adenoidectomy and Tonsillectomy
Authors: Kim Jeong-Mi , Choi Jeong-Seok
Published: September 2024

Background/Objectives: Adenoidectomy and tonsillectomy are among the most commonly performed procedures in ENT practice. The neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) are recognized inflammatory markers. This study aims to evaluate the changes in NLR, PLR, and LMR in patients undergoing adenoidectomy and tonsillectomy. Methods: The study group consisted of 980 patients who underwent adenoidectomy and/or tonsillectomy. Preoperative and postoperative inflammatory markers were measured in all patients. The NLR, LMR, and PLR values were then calculated and analyzed. Results: In patients undergoing adenoidectomy and/or tonsillectomy, the postoperative NLR was significantly lower than the preoperative NLR. Similarly, the postoperative LMR was significantly higher, and the postoperative PLR was significantly lower compared to their preoperative values. Conclusions: The significant changes in NLR, LMR, and PLR following adenoidectomy and/or tonsillectomy suggest a reduction in systemic inflammation post-surgery. These findings indicate that these procedures may contribute to the improvement of inflammatory status in patients, highlighting the potential role of these markers in monitoring surgical outcomes.