bluuebunny/crossref_metadata_2025 huggingface dataset:
Detailed Insight into Photocatalytic Inactivation of Pathogenic Bacteria in the Presence of Visible-Light-Active Multicomponent Photocatalysts
Authors: Kozak Magda , Mazierski Paweł , Żebrowska Joanna , Klimczuk Tomasz , Lisowski Wojciech , Żak Andrzej M. , Skowron Piotr M. , Zaleska-Medynska Adriana
Published: February 2024

The use of heterogeneous photocatalysis in biologically contaminated water purification processes still requires the development of materials active in visible light, preferably in the form of thin films. Herein, we report nanotube structures made of TiO2/Ag2O/Au0, TiO2/Ag2O/PtOx, TiO2/Cu2O/Au0, and TiO2/Cu2O/PtOx obtained via one-step anodic oxidation of the titanium-based alloys (Ti94Ag5Au1, Ti94Cu5Pt1, Ti94Cu5Au1, and Ti94Ag5Pt1) possessing high visible light activity in the inactivation process of methicillin-susceptible S. aureus and other pathogenic bacteria—E. coli, Clostridium sp., and K. oxytoca. In the samples made from Ti-based alloys, metal/metal oxide nanoparticles were formed, which were located on the surface and inside the walls of the NTs. The obtained results showed that oxygen species produced at the surface of irradiated photocatalysts and the presence of copper and silver species in the photoactive layers both contributed to the inactivation of bacteria. Photocatalytic inactivation of E. coli, S. aureus, and Clostridium sp. was confirmed via TEM imaging of bacterium cell destruction and the detection of CO2 as a result of bacteria cell mineralization for the most active sample. These results suggest that the membrane ruptures as a result of the attack of active oxygen species, and then, both the membrane and the contents are mineralized to CO2.
Third Harmonic Generation in Thin NbOI2 and TaOI2
Authors: Tang Tianhong , Hu Deng , Lin Di , Yang Liu , Shen Ziling , Yang Wenchen , Liu Haiyang , Li Hanting , Fan Xiaoyue , Wang Zhiwei , Wang Gang
Published: February 2024

The niobium oxide dihalides have recently been identified as a new class of van der Waals materials exhibiting exceptionally large second-order nonlinear optical responses and robust in-plane ferroelectricity. In contrast to second-order nonlinear processes, third-order optical nonlinearities can arise irrespective of whether a crystal lattice is centrosymmetric. Here, we report third harmonic generation (THG) in two-dimensional (2D) transition metal oxide iodides, namely NbOI2 and TaOI2. We observe a comparable THG intensity from both materials. By benchmarking against THG from monolayer WS2, we deduce that the third-order susceptibility is approximately on the same order. THG resonances are revealed at different excitation wavelengths, likely due to enhancement by excitonic states and band edge resonances. The THG intensity increases for material thicknesses up to 30 nm, owing to weak interlayer coupling. After this threshold, it shows saturation or a decrease, due to optical interference effects. Our results establish niobium and tantalum oxide iodides as promising 2D materials for third-order nonlinear optics, with intrinsic in-plane ferroelectricity and thickness-tunable nonlinear efficiency.
The Evaluation of a Novel Denitrifying Woodchip Bioreactor: Fairmont, MN, USA
Authors: Xu Limeimei , Holmberg Kerry , Magner Joe
Published: February 2024

The risk of nitrate contamination became a reality for Fairmont in Minnesota, when water rich in NO3-N exceeded the drinking water standard of 10 mg/L. This was unexpected because this city draws its municipal water from a chain of lakes that are fed primarily by shallow groundwater under row-crop land use. Spring soil thaw drives cold water into a subsurface pipe where almost no NO3-N reduction occurs. This paper focuses on NO3-N reduction before the water enters the lakes and no other nitrogen management practices in the watershed. A novel denitrifying bioreactor was constructed behind a sediment forebay, which then flowed into a chamber covered by a greenhouse before entering a woodchip bioreactor. In 2022 and 2023, water depth, dissolved oxygen, and temperature were measured at several locations in the bioreactor, and continuous NO3-N was measured at the entry and exit of the bioreactor. The results showed better performance at a low water depth with lower dissolved oxygen and higher water temperature. The greenhouse raised the inlet temperature in 2022 but did not in 2023. The forebay and the greenhouse may have impeded the denitrification process due to the high dissolved oxygen concentrations in the influent and the stratification of dissolved oxygen caused by algae in the bioreactor.
Twenty-Four-Hour Urinary Sugars Biomarker in a Vending Machine Intake Paradigm in a Diverse Population
Authors: Ahern Mary M. , Stinson Emma J. , Votruba Susanne B. , Krakoff Jonathan , Tasevska Natasha
Published: February 2024

Accurately measuring dietary sugars intake in large-scale epidemiological studies is necessary to understand dietary sugars’ true impact on health. Researchers have developed a biomarker that can be used to assess total sugars intake. Our objective is to test this biomarker in diverse populations using an ad libitum intake protocol. Healthy adult participants (n = 63; 58% Indigenous Americans/Alaska Natives; 60% male; BMI (mean ± SD) = 30.6 ± 7.6 kg.m2) were admitted for a 10-day inpatient stay. On day 2, body composition was measured by DXA, and over the last 3 days, ad libitum dietary intake was measured using a validated vending machine paradigm. Over the same days, participants collected daily 24 h urine used to measure sucrose and fructose. The 24 h urinary sucrose and fructose biomarker (24hruSF) (mg/d) represents the sum of 24 h urinary sucrose and fructose excretion levels. The association between the 3-day mean total sugars intake and log 24uSF level was assessed using the Pearson correlation. A linear mixed model regressing log-biomarker on total sugars intake was used to investigate further the association between biomarker, diet, and other covariates. Mean (S.D.) total sugars intake for the group was 197.7 g/d (78.9). Log 24uSF biomarker was moderately correlated with total sugars intake (r = 0.33, p = 0.01). In stratified analyses, the correlation was strongest in females (r = 0.45, p = 0.028), the 18–30 age group (r = 0.44, p = 0.079), Indigenous Americans (r = 0.51, p = 0.0023), and the normal BMI category (r = 0.66, p = 0.027). The model adjusted for sex, age, body fat percent, and race/ethnicity demonstrated a statistically significant association between 24uSF and total sugars intake (β = 0.0027, p < 0.0001) and explained 31% of 24uSF variance (marginal R2 = 0.31). Our results demonstrated a significant relationship between total sugars intake and the 24uSF biomarker in this diverse population. However, the results were not as strong as those of controlled feeding studies that investigated this biomarker.
Sleep Quality, Nutrient Intake, and Social Development Index Predict Metabolic Syndrome in the Tlalpan 2020 Cohort: A Machine Learning and Synthetic Data Study
Authors: Gutiérrez-Esparza Guadalupe , Martinez-Garcia Mireya , Ramírez-delReal Tania , Groves-Miralrio Lucero Elizabeth , Marquez Manlio F. , Pulido Tomás , Amezcua-Guerra Luis M. , Hernández-Lemus Enrique
Published: February 2024

This study investigated the relationship between Metabolic Syndrome (MetS), sleep disorders, the consumption of some nutrients, and social development factors, focusing on gender differences in an unbalanced dataset from a Mexico City cohort. We used data balancing techniques like SMOTE and ADASYN after employing machine learning models like random forest and RPART to predict MetS. Random forest excelled, achieving significant, balanced accuracy, indicating its robustness in predicting MetS and achieving a balanced accuracy of approximately 87%. Key predictors for men included body mass index and family history of gout, while waist circumference and glucose levels were most significant for women. In relation to diet, sleep quality, and social development, metabolic syndrome in men was associated with high lactose and carbohydrate intake, educational lag, living with a partner without marrying, and lack of durable goods, whereas in women, best predictors in these dimensions include protein, fructose, and cholesterol intake, copper metabolites, snoring, sobbing, drowsiness, sanitary adequacy, and anxiety. These findings underscore the need for personalized approaches in managing MetS and point to a promising direction for future research into the interplay between social factors, sleep disorders, and metabolic health, which mainly depend on nutrient consumption by region.
Anti-Inflammatory and Anti-Adipocyte Dysfunction Effects of Ficus lindsayana Latex and Root Extracts
Authors: Karinchai Jirarat , Buacheen Pensiri , Rodthayoy Daraphan , Yodweerapong Tanpitcha , Imsumran Arisa , Wongnoppavich Ariyaphong , Chantarasuwan Bhanumas , Suttisansanee Uthaiwan , Temviriyanukul Piya , Pitchakarn Pornsiri
Published: February 2024

Low-grade chronic inflammation and adipocyte dysfunction are prominent risk factors of insulin resistance and type 2 diabetes mellitus (T2DM) in obesity. Thus, prevention of inflammation and adipocyte dysfunction could be one possible approach to mitigate T2DM development. Several Ficus species have been used in traditional medicine for ameliorating inflammation and T2DM. Our previous studies reported biological effects of Ficus lindsayana including antioxidant, anti-cancer, and anti-α-glucosidase activities. Further, this study therefore investigated whether F. lindsayana latex (FLLE) and root (FLRE) extracts inhibit inflammation-stimulated insulin resistance in adipocytes and inflammation in macrophages. FLLE and FLRE (200 µg/mL) had no significant cytotoxicity for macrophages, adipocytes, and blood cells (PBMCs and RBCs). FLRE had a total flavonoid content about three times higher than FLLE, while both had similar levels of total phenolic content. FLRE showed higher abilities than FLLE in suppressing inflammation in both macrophages and adipocytes and reversing the inflammation-induced insulin resistance in adipocytes. In TNF-α-induced adipocytes, FLRE significantly improved insulin-induced glucose uptake and insulin-suppressed lipolysis, while FLLE only significantly improved glucose uptake. Moreover, FLRE and FLLE remarkably reduced chemoattractant (MCP-1) but improved adipogenic (PPARγ and CEBPα) gene expression, leading to the promotion of adipogenesis and the suppression of insulin resistance. In LPS-induced macrophages, FLRE, but not FLLE, significantly inhibited LPS-induced NO production. Moreover, FLRE significantly reduced LPS-stimulated iNOS, COX-2, IL-1β, IL-6, and TNF-α gene expression. These results may provide the potential data for the development of this plant, especially the root part, as an alternative medicine, functional ingredient, or food supplement for the prevention of inflammation and obesity-associated insulin resistance, as well as T2DM.
Synthetic Haemostatic Sealants: Effectiveness, Safety, and In Vivo Applications
Authors: Curcio Federica , Perri Paolo , Piro Paolo , Galassi Stefania , Sole Roberta , Trombino Sonia , Cassano Roberta
Published: February 2024

Rapid haemostasis during surgery is essential when one wants to reduce the duration of operations, reduce the need for transfusions, and above all when one wants to achieve better patient management. The use of haemostatic agents, sealants, and adhesives improves the haemostatic process by offering several advantages, especially in vascular surgery. These agents vary widely in their mechanism of action, composition, ease of application, adhesion to wet or dry tissue, immunogenicity, and cost. The most used are cyanoacrylate-based glues (Glubran 2) or polysaccharide hydrogel-microsphere powder (AristaTMAH). This work is based on a retrospective study carried out on a sample of patients with different vascular diseases (FAV, pseudoaneurysm, and PICC application) in which two different haemostatic sealants were used. The aim was to assess the safety, the advantages, and the ability of both sealants to activate the haemostatic process at the affected site, also in relation to their chemical-physical characteristics. The obtained results showed that the application of Glubran 2 and AristaTMAH as surgical wound closure systems is effective and safe, as the success achieved was ≥94% on anastomoses of FAV, 100% on stabilization of PICC catheters, and ≤95% on pseudoaneurysms.
Radiofrequency Combined with Intratumoral Immunotherapy: Preclinical Results and Safety in Metastatic Colorectal Carcinoma
Authors: Seguin Johanne , El Hajjam Mostafa , Legagneux Josette , Diakhaby Sarah , Mignet Nathalie , Boudy Vincent , Toussaint Balthazar , Peschaud Frederique , Emile Jean François , Capron Claude , Malafosse Robert
Published: February 2024

Radiofrequency ablation (RFA) of cancer induces an anti-tumor immunity, which is insufficient to prevent recurrences. In mice, RFA–intratumoral immunotherapy by granulocyte–macrophage colony-stimulating factor (GM-CSF) and Bacillus Calmette-Guerin resulted in complete metastases regression. Infectious risk in human needs replacement of live vaccines. Intratumoral purified protein derivatives (PPD) have never been tested in digestive cancers, and the safety of intratumoral immunotherapy after RFA has not yet been validated in human models. We investigated the therapeutic efficacy of combined radiofrequency ablation (RFA) and intratumoral immunotherapy (ITI) using an immune-muco-adherent thermogel (IMT) in a mouse model of metastatic colorectal cancer (CRC) and the safety of this approach in a pig model. Intratumoral stability of the immunogel was assessed using magnetic resonance imaging (MRI) and bioluminescent imaging. Seventy-four CT26 tumor-bearing female BALB/c mice were treated with RFA either alone or in combination with intratumoral IMT. Regression of distant metastasis and survival were monitored for 60 days. Six pigs that received liver radiofrequency and intralesional IMT injections were followed for 15 days. Experimental gel embolisms were treated using an intravascular approach. Pertinent rheology of IMT was confirmed in tumors, by the signal stability during 3 days in MRI and 7 days in bioluminescence imaging. In mice, the abscopal effect of RFA–intratumoral immunotherapy resulted in regression of distant lesions completed at day 16 vs. a volume of 350 ± 99.3 mm3 in the RFA group at day 25 and a 10-fold survival rate at 60 days. In pigs, injection of immunogel in the liver RFA area was safe after volume adjustment without clinical, hematological, and liver biology disorder. Flow cytometry showed an early increase in CD3 TCRγδ+T cells at D7 (p < 0.05) and a late decrease in CD29+-CD8 T cells at D15 (p < 0.05), reflecting the inflammation status changes. Systemic GM-CSF release was not detectable. Experimental caval and pulmonary thermogel embolisms were treated by percutaneous catheterism and cold serum infusion. RFA–intratumoral immunotherapy as efficient and safe mini-invasive interventional oncology is able to improve ablative treatment of colorectal liver metastases.
From Sub-Solar to Super-Solar Chemical Abundances along the Quasar Main Sequence
Authors: Marziani Paola , Floris Alberto , Deconto-Machado Alice , Panda Swayamtrupta , Sniegowska Marzena , Garnica Karla , Dultzin Deborah , D’Onofrio Mauro , Del Olmo Ascensión , Bon Edi , Bon Nataša
Published: February 2024

The 4D (four-dimensional) eigenvector 1 (E1) sequence has proven to be a highly effective tool for organizing observational and physical properties of type-1 active galactic nuclei (AGNs). In this paper, we present multiple measurements of metallicity for the broad line region gas, from new and previously-published data. We demonstrate a consistent trend along the optical plane of the E1 (also known as the quasar main sequence), defined by the line width of Balmer hydrogen Hβ profile and by a parameter measuring the prominence of singly-ionized iron emission. The trend involves an increase from sub-solar metallicity in correspondence with extreme Population B (weak Feii emission, large Hβ FWHM (full width at half maximum)) to metallicity several tens the solar value in correspondence with extreme Population A (strongest Feii optical emission, narrower Hβ profiles). The data establish the metallicity as a correlate of the 4DE1/main sequence. If the considerably high metallicity (Z≳10Z⊙, solar metallicity) gas is expelled from the sphere of influence of the central black hole, as indicated by the widespread evidence of nuclear outflows and disk wind in the case of sources radiating at a high Eddington ratio, then it is possible that the outflows from quasars played a role in chemically enriching the host galaxy.
Emergent Flow Signal and the Colour String Fusion
Authors: Prokhorova Daria , Andronov Evgeny
Published: February 2024

In this study, we develop the colour string model of particle production, based on the multi-pomeron exchange scenario, to address the controversial origin of the flow signal measured in proton–proton inelastic interactions. Our approach takes into account the string–string interactions but does not include a hydrodynamic phase. We consider a comprehensive three-dimensional dynamics of strings that leads to the formation of strongly heterogeneous string density in an event. The latter serves as a source of particle creation. The string fusion mechanism, which is a major feature of the model, modifies the particle production and creates azimuthal anisotropy. Model parameters are fixed by comparing the model distributions with the ATLAS experiment proton–proton data at the centre-of-mass energy s=13 TeV. The results obtained for the two-particle angular correlation function, C(Δη,Δϕ), with Δη and Δϕ differences in, respectively, pseudorapidities and azimuthal angles between two particles, reveal the resonance contributions and the near-side ridge. Model calculations of the two-particle cumulants, c2{2}, and second order flow harmonic, v2{2}, also performed using the two-subevent method, are in qualitative agreement with the data. The observed absence of the away-side ridge in the model results is interpreted as an imperfection in the definition of the time for the transverse evolution of the string system.
Evaluation of Tomato Germplasm against Tomato Brown Rugose Fruit Virus and Identification of Resistance in Solanum pimpinellifolium
Authors: Jaiswal Namrata , Chanda Bidisha , Gilliard Andrea , Shi Ainong , Ling Kai-Shu
Published: February 2024

The tomato is one of the most important vegetable crops grown worldwide. Tomato brown rugose fruit virus (ToBRFV), a seed-borne tobamovirus, poses a serious threat to tomato production due to its ability to break the resistant genes (Tm-1, Tm-2, Tm-22) in tomatoes. The objective of this work was to identify new resistant source(s) of tomato germplasm against ToBRFV. To achieve this aim, a total of 476 accessions from 12 Solanum species were tested with the ToBRFV US isolate for their resistance and susceptibility. As a result, a total of 44 asymptomatic accessions were identified as resistant/tolerant, including thirty-one accessions of S. pimpinellifolium, one accession of S. corneliomulleri, four accessions of S. habrochaites, three accessions of S. peruvianum, and five accessions of S. subsection lycopersicon hybrid. Further analyses using serological tests identified four highly resistant S. pimpinellifolium lines, PI 390713, PI 390714, PI 390716, and PI 390717. The inheritance of resistance in the selected lines was verified in the next generation and confirmed using RT-qPCR. To our knowledge, this is a first report of high resistance to ToBRFV in S. pimpinellifolium. These new genetic resources will expand the genetic pool available for breeders to develop new resistant cultivars of tomato against ToBRFV.
Economic Injury Levels and Economic Thresholds for Leucoptera coffeella as a Function of Insecticide Application Technology in Organic and Conventional Coffee (Coffea arabica), Farms
Authors: Picanço Filho Marcelo Coutinho , Lima Eraldo , Carmo Daiane das Graças do , Pallini Angelo , Walerius Adriana Helena , da Silva Ricardo Siqueira , Sant’Ana Letícia Caroline da Silva , Lopes Pedro Henrique Queiroz , Picanço Marcelo Coutinho
Published: February 2024

Leucoptera coffeella (Lepidoptera: Lyonetiidae) is one of the main pests in coffee crops. The economic injury level (EIL) is the lowest density of the pest at which economic damages match the costs of control measures. The economic threshold (ET) is the density of the pest at which control measures must be taken so that this population does not reach the EIL. These are the main indices used for pest control decision-making. Control of L. coffeella is carried out by manual, tractor, airplane or drone applications. This work aimed to determine EILs and ETs for L. coffeella as a function of insecticide application technology in conventional and organic Coffea arabica crops. Data were collected over five years in commercial C. arabica crops on seven 100 ha central pivots. The cost of control in organic crops was 16.98% higher than conventional. The decreasing order of control cost was manual > drone > airplane > tractor application. Coffee plants were tolerant to low densities (up to 15% mined leaves) of the pest that caused losses of up to 6.56%. At high pest densities (54.20% mined leaves), losses were high (85.62%). In organic and conventional crops and with the use of different insecticide application technologies, EIL and ET were similar. The EIL and ET were 14% and 11% of mined leaves, respectively. Therefore, these indices can be incorporated in integrated pest management programs in C. arabica crops. The indices determined as a function of insecticide application technology in organic and conventional coffee are important as they serve producers with different technological levels. Additionally, EILs and ETs can contribute to more sustainable production, as control methods will only be employed when the pest density reaches these indices.
Transcriptome-Based Identification of the SaR2R3-MYB Gene Family in Sophora alopecuroides and Function Analysis of SaR2R3-MYB15 in Salt Stress Tolerance
Authors: Wang Yuan , Yang Xiaoming , Hu Yongning , Liu Xinqian , Shareng Tuya , Cao Gongxiang , Xing Yukun , Yang Yuewen , Li Yinxiang , Huang Weili , Wang Zhibo , Bai Gaowa , Ji Yuanyuan , Wang Yuzhi
Published: February 2024

As one of the most prominent gene families, R2R3-MYB transcription factors significantly regulate biochemical and physiological processes under salt stress. However, in Sophora alopecuroides, a perennial herb known for its exceptional saline alkali resistance, the comprehensive identification and characterization of SaR2R3-MYB genes and their potential functions in response to salt stress have yet to be determined. We investigated the expression profiles and biological functions of SaR2R3-MYB transcription factors in response to salt stress, utilizing a transcriptome-wide mining method. Our analysis identified 28 SaR2R3-MYB transcription factors, all sharing a highly conserved R2R3 domain, which were further divided into 28 subgroups through phylogenetic analysis. Some SaR2R3-MYB transcription factors showed induction under salt stress, with SaR2R3-MYB15 emerging as a potential regulator based on analysis of the protein–protein interaction network. Validation revealed the transcriptional activity and nuclear localization of SaR2R3-MYB15. Remarkably, overexpression of SaR2R3-MYB15 in transgenic plants could increase the activity of antioxidant enzymes and the accumulation of proline but decrease the content of malondialdehyde (MDA), compared with wild-type plants. Moreover, several salt stress-related genes showed higher expression levels in transgenic plants, implying their potential to enhance salt tolerance. Our findings shed light on the role of SaR2R3-MYB genes in salt tolerance in S. alopecuroides.
Exploring the Effect of Cetylpyridinium Chloride Addition on the Antibacterial Activity and Surface Hardness of Resin-Based Dental Composites
Authors: Khan Sara , Amin Faiza , Amin Rafat , Kumar Naresh
Published: February 2024

The aim of this study was to evaluate the effect of cetylpyridinium chloride (CPC) addition on the antibacterial and surface hardness characteristics of two commercial resin-based dental composites (RBDCs). A total of two hundred and seventy (n = 270) specimens from Filtek Z250 Universal and Filtek Z350 XT flowable RBDCs were fabricated with the addition of CPC at 2 %wt and 4 %wt concentrations to assess their antibacterial activity using the agar diffusion test and direct contact inhibition test, and their surface hardness using the Vickers microhardness test after 1 day, 30 days, and 90 days of aging. A surface morphology analysis of the specimens was performed using a scanning electron microscope (SEM). The RBDCs that contained 2 %wt and 4 %wt CPC demonstrated significant antibacterial activity against Streptococcus mutans up to 90 days, with the highest activity observed for the 4 %wt concentration. Nevertheless, there was a reduction in antibacterial effectiveness over time. Moreover, compared to the control (0 %wt) and 2 %wt CPC groups, the universal RBDCs containing 4 %wt CPC exhibited a notable decrease in surface hardness, while all groups showed a decline in hardness over time. In conclusion, the satisfactory combination of the antibacterial effect and surface hardness property of RBDCs was revealed with the addition of a 2 %wt CPC concentration.
Optimizing the Salt-Processing Parameters of Achyranthes bidentata and Their Correlation with Anti-Osteoarthritis Effect
Authors: Zhu Jieqiang , Shen Lisha , Shen Guofang , Tao Yi
Published: February 2024

Achyranthes bidentata is always salt-processed before being prescribed for treating osteoarthritis. Yet the salt-processing parameters have not been optimized, and the specific bioactive constituents responsible for the osteoarthritis effect of salt-processed A. bidentata have not been fully elucidated. In this study, a Box–Behnken experimental design was chosen for the optimization of the salt-processing parameters of A. bidentata, including stir-frying time, concentration of brine, and soak time. Meanwhile, HPLC–Q-TOF-MS was utilized to analyze the chemical profiles of various batches of raw and salt-processed A. bidentata. The anti-inflammatory potential of nine batches of both raw and salt-processed A. bidentata was assessed via a cyclooxygenase-2 (COX-2) inhibitory assay. A gray correlation analysis was conducted to correlate the peak areas of the compounds in raw and salt-processed A. bidentata with their COX-2 inhibitory effects. Finally, the optimal salt-processing conditions are as follows: soak time: 29 min; concentration of brine: 1.8%; stir-frying time: 4.4 min. Twenty-nine compounds were identified. Eight compounds were found to have a strong positive correlation with anti-inflammatory activity, as confirmed by the COX-2 inhibitory assay. Notably, this is the first report of the COX-2 inhibitory effects of sanleng acid, stachysterone D, dihydroactinidiolide, N-cis-feruloyl-3-methoxytyramine, 9,12,13-trihydroxy-10-octadecenoic acid, azelaic acid, and dehydroecdysone.
Analysis of Influencing Factors of Slippage and the Dynamic Process of Fault Slip Caused by Multi-Stage Fracturing
Authors: Lu Zongyu , Lian Wei , Li Jun , Wang Nenghao
Published: February 2024

Casing deformation is evident during the development of shale oil and gas wells in the Sichuan and Junggar Basins in China. Their casing deformation characteristics, distribution law of deformation points, and main controlling factors were analyzed. According to the analysis results, shear is the main cause of casing deformation of shale oil and gas wells in the Sichuan and Junggar Basins in China and has the characteristics of “a dense heel end and a sparse toe end”. Faults account for 75% of casing deformation points, and fault slip caused by multi-stage fracturing is the primary factor responsible. The calculation model for fault slip that takes into account fracturing fluid invasion was established, and the dynamic variation law of fault slip was clarified: the fracturing fluid intruded into the fault, the relative dislocation of the damaged fault was caused by gravity, and the fault slippage was caused by the increase in fault activation length. This resulted in a linear increase in fault slippage, and the slippage reached its maximum when the fracturing fluid completely penetrated the fault and reached the fault boundary. The slip amount has a positive correlation with the fault length and the in situ stress difference; it increases first and then decreases with the increase in the fault dip angle. The slip amount reaches its maximum when the fault dip angle reaches 45°.
Correction: Ismaeil et al. Ameliorative Effect of Heat-Killed Lactobacillus plantarum L.137 and/or Aloe vera against Colitis in Mice. Processes 2020, 8, 225
Authors: Ismaeil Heba , Abdo Walied , Amer Said , Tahoun Amin , Massoud Diaa , Zanaty Eatemad , Bin-Jumah May , Mahmoud Ayman M.
Published: February 2024

In the original publication [...]
Optimizing Oxygen Electrode Bifunctionality with Platinum and Nickel Nanoparticle-Decorated Nitrogen-Doped Binary Metal Oxides
Authors: Mladenović Dušan , Aykut Yasemin , Yurtcan Ayşe B. , Soylu Gulin S. P. , Santos Diogo M. F. , Miljanić Šćepan , Šljukić Biljana
Published: February 2024

Developing bifunctional oxygen electrode materials with superior activity for oxygen reduction (ORR) and oxygen evolution (OER) reactions is essential for advancing regenerative fuel cell and rechargeable metal–air battery technologies. This present work deals with the synthesis and characterization of electrocatalysts containing Pt and Ni nanoparticles supported on nitrogen-doped mixed metal oxides (Mn2O3-NiO) and the systematic evaluation of their bifunctional ORR/OER performance in an alkaline medium. These electrocatalysts have been successfully synthesized by a simple and fast microwave method. PtNi/Mn2O3-NiO-N with a binary metal oxide-to-N ratio of 1:2 demonstrated the best performance among the studied materials regarding bifunctional electrocatalytic activity (∆E = 0.96 V) and robust stability.
Nonparametric Kernel Smoothing Item Response Theory Analysis of Likert Items
Authors: Baghaei Purya , Effatpanah Farshad
Published: February 2024

Likert scales are the most common psychometric response scales in the social and behavioral sciences. Likert items are typically used to measure individuals’ attitudes, perceptions, knowledge, and behavioral changes. To analyze the psychometric properties of individual Likert-type items and overall Likert scales, mostly methods based on classical test theory (CTT) are used, including corrected item–total correlations and reliability indices. CTT methods heavily rely on the total scale scores, making it challenging to directly examine the performance of items and response options across varying levels of the trait. In this study, Kernel Smoothing Item Response Theory (KS-IRT) is introduced as a graphical nonparametric IRT approach for the evaluation of Likert items. Unlike parametric IRT models, nonparametric IRT models do not involve strong assumptions regarding the form of item response functions (IRFs). KS-IRT provides graphics for detecting peculiar patterns in items across different levels of a latent trait. Differential item functioning (DIF) can also be examined by applying KS-IRT. Using empirical data, we illustrate the application of KS-IRT to the examination of Likert items on a psychological scale.
The Impact of Dementia on the Psychosocial Well-Being of Informal Caregivers in Asia: A Scoping Review Comparing High-Income and Low–Middle-Income Countries
Authors: Abayon Aiza Amor Padre-e , Raymonds Millicent , Brahmbhatt Priya , Samnani Shelina , Hanna Fahad
Published: February 2024

The need for informal caregiving has become a crucial topic for researchers and policymakers. This review explores the psychosocial impact on caregivers providing dementia care in high-income and low–middle-income Asian countries. A scoping review was undertaken following the Joanna Briggs Institute (JBI) protocol. A systematic search of four databases (PubMed, ProQuest, Medline, and Medline Complete) was conducted. Articles were screened following the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. Fourteen articles (11 cross-sectional, 1 longitudinal, 1 case-control, and 1 descriptive phenomenological study) were selected for the final analysis. The most frequently reported findings from low–middle-income countries were dementia caregivers working longer hours and experiencing financial issues, poor physical health, and lower life satisfaction, which progressively and collectively affected caregivers’ psychosocial well-being and quality of life. However, the impact was less significant in high-income Asian countries, particularly those where efforts are being made to identify the burdens associated with caring for people with dementia and providing appropriate support. This review demonstrates clear evidence that caring for people with dementia may affect informal caregivers’ quality of life, particularly in low–middle-income Asian countries. Systematic reviews and meta-analyses may be needed to confirm these findings.
Christian Citizens in a Democratic State: Is a True Separation of Church and State Really Possible?
Authors: Haines David
Published: February 2024

In many North American Protestant circles, especially those with Baptist or Free Church roots, the notion of the total separation of church and state is presented as the ideal to be attained in all church and state relations. We are told that the state should have no legislative power to ordain anything in relation to church doctrine or practice, and that the church should be entirely excluded from all political, secular, or state actions. In this paper, we are going to suggest that such an approach to church–state relations (even though some might think that it flows from or is necessary for democracy) is, in fact, impossible in a true democracy. We will first consider the nature of the church and the state, and present three principles that Maritain suggests are first principles in this debate. We will then look at the classical notion of the “Citizen”. We will conclude by arguing that based upon the nature of a citizen, of the church, and of the state, a strict separation of church and state is, in fact, impossible.
An Ecolinguistic Reading of the Creation Story in the Bible: Beyond and Within
Authors: Pennarola Cristina
Published: February 2024

Taking the cue from the recent developments in ecotheology and its concern with a sustainable world where humans, animals and plants may live in harmony with each other, this paper sets out to investigate the representation of nature in the Bible’s origin story. The creation in Genesis is analyzed according to Arran Stibbe’s ecolinguistic framework and “the stories we live by”. The tools used (narratives, evaluations, frames, metaphors, erasure and ideologies) have illuminated an outstandingly popular story and highlighted its potential for meaning in the tension between contrasting worldviews: dominion vs. stewardship; innocence vs. knowledge; theocentrism vs. anthropocentrism. The analysis of narrative and linguistic elements suggests that the world beyond—represented by God, the heavens, the sky—coincides with the order within the whole of creation. The origin story proves deeply ambivalent as it features humans in two antithetical roles depending on the story’s timeline: first as guardians of the created world and then as outcasts full of shame. Going against God’s command is framed as an act of self-betrayal that breaks the unbreakable bond between humans and God, and subverts the perfect harmony of human society within the natural world.
Vision-Based Mid-Air Object Detection and Avoidance Approach for Small Unmanned Aerial Vehicles with Deep Learning and Risk Assessment
Authors: Lai Ying-Chih , Lin Tzu-Yun
Published: February 2024

With the increasing demand for unmanned aerial vehicles (UAVs), the number of UAVs in the airspace and the risk of mid-air collisions caused by UAVs are increasing. Therefore, detect and avoid (DAA) technology for UAVs has become a crucial element for mid-air collision avoidance. This study presents a collision avoidance approach for UAVs equipped with a monocular camera to detect small fixed-wing intruders. The proposed system can detect any size of UAV over a long range. The development process consists of three phases: long-distance object detection, object region estimation, and collision risk assessment and collision avoidance. For long-distance object detection, an optical flow-based background subtraction method is utilized to detect an intruder far away from the host. A mask region-based convolutional neural network (Mask R-CNN) model is trained to estimate the region of the intruder in the image. Finally, the collision risk assessment adopts the area expansion rate and bearing angle of the intruder in the images to conduct mid-air collision avoidance based on visual flight rules (VFRs) and conflict areas. The proposed collision avoidance approach is verified by both simulations and experiments. The results show that the system can successfully detect different sizes of fixed-wing intruders, estimate their regions, and assess the risk of collision at least 10 s in advance before the expected collision would happen.
Ultrasound-Based Prognostic Anatomical Parameters for Post-Prostatectomy Incontinence: A Systematic Review
Authors: Pham Cecile T. , Cohen Jordan E. , Patel Manish I.
Published: February 2024

Background: A number of assessment methods for the pelvic floor have been described. Male pelvic floor ultrasound is an accessible, noninvasive assessment tool. Objective: To evaluate current published literature on anatomical parameters on pre- and postoperative ultrasound imaging of the male pelvic floor and correlation with continence status following radical prostatectomy (RP). Methods: A comprehensive literature search was conducted using the PRISMA guidelines to identify publications up to November 2022. Exclusion criteria consisted of animal studies, non-English articles, case reports, reviews and abstracts or reports from conferences. A full-text review was performed on 12 papers using ultrasound to assess pelvic floor anatomy and correlation with continence status following RP. Results: A total of 18 anatomical parameters were evaluated using US. Membranous urethral length (MUL), striated urethral sphincter (SUS) morphology and activation were most commonly studied. Shorter pre- and postoperative MUL, decreased preoperative SUS thickness and vascularity, postoperative discontinuity of SUS muscle fibres and decreased SUS activation are associated with post-prostatectomy incontinence (PPI). There is a paucity of data comparing anatomical changes in men prior to and following RP. The benefits of transperineal ultrasound are that it is minimally invasive, accessible, provides dynamic imaging of all three striated muscle complexes simultaneously and includes a bony landmark to reference measures of pelvic floor muscle displacement. Conclusions: Ultrasound evaluation of the male pelvic floor is an evolving field as there is development in technology and understanding of pelvic floor anatomy. It is an accessible and dynamic imaging modality, which allows both morphological and functional assessment of pelvic floor anatomy and its role in PPI. MUL and SUS morphology and activation are associated with continence status following RP. Several other anatomical parameters that may predict PPI were identified. Current literature is limited by small, single-centre studies with heterogeneous cohorts and methodologies.
Robotic Precision vs. Human Dexterity—Benchtop Comparative Study of Free-Hand vs. Robotic-Assisted Puncture in Fluoroscopy-Guided Percutaneous Nephrolithotomy
Authors: Lim Jeffery Ze Kang , Ann Chai Chu , Phyo Aung Kyaw , Kumaran Kanesh , Nazran Ahmad , Kuppusamy Shanggar , Ong Teng Aik , Yeoh Wei Sien
Published: February 2024

Introduction: Percutaneous nephrolithotomy (PCNL) is the standard procedure for treating large kidney stones, especially those measuring over 20 mm or staghorn stones. Accurate placement of the tract into the renal collecting system of interest is crucial. Objective: To compare the free-hand puncture technique with robotic-assisted puncture during fluoroscopy-guided PCNL on a phantom kidney model in terms of efficiency and safety. A self-assessment of confidence levels after each puncture was recorded. Study Design: This prospective single-center benchtop study was conducted at the University Malaya Medical Centre (UMMC). Four urological residents participated and performed phantom punctures using both the free-hand bull’s eye technique and the automated needle targeting system with X-ray (ANT-X). Each resident performed a total of 60 punctures on the renal phantom models, with 30 punctures using the free-hand technique and 30 punctures using the ANT-X robotic-assisted system. Results: A total of 240 needle insertions were conducted, with 120 in the ANT-X group and 120 in the free-hand group. The success rate of needle insertions was 100% in both groups. However, the study revealed that the ANT-X group required, on average, an additional 51 s for needle puncture compared to the free-hand group (p < 0.001). In terms of fluoroscopic exposure, the ANT-X group exhibited significantly lower radiation exposure compared to the free-hand group (p < 0.001). Sub-analysis showed that puncture time remained consistent regardless of the technique used, but fluoroscopic screening time decreased with increasing participant experience. The ANT-X group also resulted in significantly lower radiation exposure during initial sessions compared to the free-hand technique. Surgeons’ self-assessment of confidence levels indicated a high level of confidence in needle puncture. Conclusions: Our benchtop study comparing the efficacy and safety between free-hand and ANT-X phantom punctures revealed comparable results. The needle puncture technique facilitated by the ANT-X system showed promising results in terms of reducing fluoroscopic exposure, albeit at the cost of longer operative times. This technology holds promise for novice surgeons who are in the early stages of their learning curve and might be useful for experienced surgeons looking to reduce radiation exposure.
Social Theory and Navigating Indeterminacy: A Configurational Analysis of Iranian Youth’s Identity Construction in Contemporary Iran
Authors: Jong Abbas
Published: February 2024

An emerging disparity within contemporary social science highlights a disconnection between the world in the process of metamorphosing and cosmopolitanization and the knowledge of the social world that is still trapped in the cognitive assumptions of modern episteme, which provided the conditions for the emergence of modern social sciences a century ago. This divide inhibits the efficacy of social analysis in comprehending and elucidating contemporary phenomena. This article advocates for a shift in the ontology of social theory and science towards the cosmopolitanization of the world, characterized by the prioritization of indeterminacy and fluidity in the construction of social phenomena. It investigates the epistemological implications and prerequisites of this ontological transformation, favoring a post-foundationalist approach as the most suitable epistemological framework. In response to the challenges posed by the uncertainty and indeterminacy of cosmopolitanization, after reviewing some of the existing theoretical efforts to address and provide alternatives to this challenge, the article proposes the examination of social configurations as the most fitting subjects for study. This approach necessitates the suspension of conventional, given, regulated categories, and trans-historical theories. It underscores the importance of recognizing configurations as incomplete, contingent units shaped within specific historical contexts and moments. The fluidity, relationality, and indeterminacy of configurations situated between the universal and the singular make them suitable for analysis at the level of particular. After elaborating on the most important features of social configurations, finally, by employing the proposed theoretical framework, this article aims to investigate its effectiveness in analyzing the process of identity construction among Iranian youth in Tehran in the context of the cosmopolitanization of reality, particularly in the face of the Islamist regime of Iran’s official politics of identity. Through a review and revision of selected empirical studies on youth identity construction in the consumer spaces of Tehran, based on the idea of social configurations within the framework of cosmopolitanization, it is argued that the genuine understanding of identity politics in contemporary Iran is not rooted in conventional analytical norms and categories but rather in a comprehensible conceptual apparatus characterized by fluidity and indeterminacy, capable of effectively making sense of the conflict between the politics of determinacy and indeterminacy in Iranian everyday life.
Acute Hemodynamic, Metabolic, and Hormonal Responses to a Boxing Exergame with and without Blood Flow Restriction in Non-Athlete Young Individuals
Authors: Karimi Zohreh , Mousavi Zeynabalsadat , Nordvall Michael , Wong Alexei , Bagheri Reza , Dutheil Frederic
Published: February 2024

Background: This study aimed to compare acute hemodynamic, metabolic (glucose and blood lactate concentrations), hormonal (growth hormone and normetanephrine), heart rate variability (HRV), and rating of perceived exertion (RPE) responses before and after bouts of a boxing exergame with and without blood flow restriction (BFR) in non-athlete young individuals. Methods: Fourteen participants (age: 30 ± 10 y; BMI: 21 ± 3 kg.m−2) participated in two sessions of a 20 min boxing exergame. During week one, the participants were randomly divided into two groups and played against one another under normal (n = 7) and BFR (n = 7) conditions. Over the next exercise session, participants were then reallocated to the opposite condition (normal vs. BFR) for data collection. Hemodynamic, metabolic, HRV, and hormonal parameters were measured before and immediately after the exercise protocols. Results: Playing exergame led to a significant increase in hemodynamic variables (except for diastolic blood pressure) regardless of BFR condition with no between-group differences. Regarding HRV, significant reductions in total power (TP) and low-frequency (LF) waves were identified in the non-BFR group (p < 0.0001) compared with the BFR group. Conversely, a significant increase in very LF (VLF) waves was noted for the BFR group (p = 0.050), compared with the non-BFR group. Significant increases were observed in serum concentrations of growth hormone, normetanephrine, and blood lactate concentration from pre- to post-exercise under both conditions (p ≤ 0.05), with no significant differences between the groups. Moreover, no statistically significant changes were observed in glucose levels. RPE responses were significantly greater (p ≤ 0.05) in the BFR group compared with the non-BFR group throughout the exercise session. Conclusions: We observed similar hemodynamic, hormonal, and metabolic responses after an acute boxing exergame session in young individuals, whether conducted with or without BFR. However, notable differences were observed in certain HRV markers and RPE. Specifically, the inclusion of BFR resulted in an elevation of VLF and a heightened perceived exertion. These findings suggest that BFR may alter cardiac autonomic and perceptual responses during exergaming. Further research is warranted to understand the long-term implications and potential benefits of incorporating BFR into exergaming routines.