bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of Mental Health First Aid Training Courses on Patients’ Mental Health
Authors: Zeng Fanli , Zhong Dexia , Chen Xi , Li Hongmei , Tian Xiaofei
Published: September 2022

Background. With the prevalence of mental issues worldwide, more and more people are suffering from psychological torture. Mental Health Gap Action Program (mhGAP) has been introduced to improve the life quality of humans. Objectives. To explore and synthesize evidence of participants’ experience of mental health first aid (MHFA) training course. Method. Peer-reviewed qualitative evidence was systematically reviewed and thematically synthesized. Cumulative Index to Nursing and Allied Health Literature (CINAHL), Medical Literature Analysis and Retrieval System Online (MEDLINE), Psychological Information (PsycINFO), PubMed, Psych ARTICLES, Web of Science, Joanna Briggs Institute (JBI), and National Institute for Health and Care Excellence (NICE) databases were searched for the inception of the present study. The study’s quality was appraised using the Critical Appraisal Checklist for Qualitative Research of Joanna Briggs Institute (JBI) appraisal tool. All the participants who have attended the MHFA training course (excluding instructors) setting were included. Results. Six papers published between 2005 and 2019 were included for thematic synthesis. The review indicated that MHFA had been a positive experience for participants. Conclusions. MHFA courses can provide participants with professional knowledge of mental health counseling and improve their knowledge, practice, and attitudes towards their patients. Professional MHFA training courses should therefore be popularized and promoted among other populations.
Comprehensive Analysis of Novel Genes and Pathways Associated with Osteogenic Differentiation of Adipose Stem Cells
Authors: Gao Qiuni , Ma Xiaorong , Qi Zuoliang
Published: September 2022

Background. Adipose-derived stem cells (ADSCs) are an important alternative source of mesenchymal stem cells (MSCs) and show great promise in tissue engineering and regenerative medicine applications. However, identifying the novel genes and pathways and finding the underlying mechanisms regulating ADSCs osteogenic differentiation remain urgent. Methods. We downloaded the gene expression profiles of GSE63754 and GSE37329 from the Gene Expression Omnibus (GEO) Database. We derived differentially expressed genes (DEGs) before and after ADSC osteogenic differentiation, followed by Gene Ontology (GO) functional and KEGG pathway analysis and protein-protein interaction (PPI) network analysis. 211 differentially expressed genes (142 upregulated genes and 69 downregulated genes) were aberrantly expressed. GO analysis revealed that these DEGs were associated with extracellular matrix organization, protein extracellular matrix, and semaphorin receptor binding. Conclusions. Our study provides novel genes and pathways that play important roles in regulating ADSC osteogenic differentiation, which may have potential therapeutic targets for clinic.
Intelligent Mobility System for Improving the Blind Pedestrian Independent Behavior in Unknown Outdoor Environments
Authors: González-Lorence Armida , Navarrete-Fernández Ángel C. , Ayala-Landeros Rosana , Soto-Osornio Juan E. , Ayala-Landeros José G.
Published: September 2022

The second cause of disability in Mexico is visual impairment; 26% population is blind. Even though blind people maintain a lower quality’s life than sighted people, there is not enough social interest to develop comprehensive solutions that improve it. Although many voice-activated emerging technologies use artificial intelligence to get human-machine communication through intelligent virtual assistants, such as Alexa, Siri, Google Home, and Cortana, among others, in reality, there have not been developed specific tools just for blind people that help them to improve their independent behavior because they always depend on other people in doing their daily tasks, more even when they need to move around unknown environments for them. This document reports the development of an autonomous mobility system to be operated by blind people. By audio reconstruction, it is possible to dictate, to the blind pedestrian, in real-time, the presence of traffic lights, crosswalks, and information about their current location. This system employs real-time computer vision tools, artificial intelligence, audio playback systems, and location systems, and it improves the independent behavior of blind people because they could move through unknown environments without the assistance of any sighted person, giving them greater independence and consequently increasing their life’s quality.
Update Research Advances in the Application of Transcranial Magnetic Stimulation in the Treatment of Schizophrenia
Authors: Wu Yanhai , Yang Zucheng , Cui Shu
Published: September 2022

Schizophrenia presents a chronic progressive course and requires long-term treatment. The current treatment of schizophrenia is mainly based on antipsychotic drugs, but drugs are ineffective for the negative symptoms and cognitive dysfunction of schizophrenia, and long-term medication may increase the burden on the endocrine and circulatory systems of patients. Repetitive transcranial magnetic stimulation is a noninvasive, painless, safe, efficacious, and economical physical therapy measure that has achieved good results in the treatment of schizophrenia. This paper reviews the progress of research on the clinical application of transcranial magnetic stimulation in the treatment of schizophrenia.
Miniaturized Dual-Band Antenna for GSM1800, WLAN, and Sub-6 GHz 5G Portable Mobile Devices
Authors: Abolade Jeremiah O. , Konditi Dominic B. O. , Mpele Pierre M. , Orimogunje Abidemi M. , Oguntoye Jonathan P.
Published: September 2022

Miniature devices are becoming increasingly demanded as fifth-generation (5G) technology is been deployed. This has necessitated the need to miniaturize all the various components of 5G enabling systems. It is a well-known fact that without the antenna, there is no wireless communication as it forms the link between the space and the wired network. Hence, the miniaturization of the antenna will contribute to the miniaturization of the entire wireless system. In this work, a miniature dual-band ultracompact antenna based on an opened-B-shaped (OBS) patch, a partial ground, and a ground protruding stub is presented. The antenna size is

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. The proposed antenna is etched on a rogers (RT5880) substrate and fed with a 50 Ω asymmetric microstrip feedline. The proposed OBS antenna is fabricated and measured. In addition, the equivalent circuit of the proposed OBS antenna is designed and analyzed using AWR®. The antenna operates at a center frequency of 1.85 GHz and 5.89 GHz with an impedance bandwidth of 10.41% and 36.29%, respectively, which means that the first and second bands are narrow and wide bands, respectively. Furthermore, the mean peak gain of the proposed OBS antenna at lower and upper bands are 4.1 dB and 3.95 dB, respectively. More so, the radiation pattern antenna shows a quasiomnidirectional at E-plane and omnidirectional at H-plane. There is a good agreement between simulated and measured results. Therefore, the proposed OBS antenna is a suitable candidate for future portable mobile devices.
Alginate‐Based Nanosystems for Therapeutic Applications
Authors: Lakkakula Jaya , Roy Arpita , Krishnamoorthy Karan , Alghamdi Saad , Almehmadi Mazen , Gujarathi Pratik , Pansare Prachi , Allahyani Mamdouh , Abdulaziz Osama , Velhal Kamini , Khatun Most. Chand Sultana , Hossain Md. Jamal
Published: September 2022

Alginate is being explored widely for an array of medicinal and diagnostic measures by way of nanosystems fabricated for techniques along the lines of drug delivery, imaging, tissue regeneration, etc. Their biocompatibility, nontoxicity, sensitivity to pH, mucoadhesiveness, and biodegradability have invited an extensive body of work in this field. Their gelling ability facilitates the encapsulation of different molecules like drugs, proteins, and genes, through the formation of multidimensional matrices. Furthermore, the feasibility of alginates for physical and chemical modification allows appropriate synthesis of nanosystems for their application. The current review highlights delivery of therapeutic compounds via alginate nanosystems as an effective, eco‐friendly alternative for expediting controlled and target‐specific release.
Quantitative Expression of SFN, lncRNA CCDC18-AS1, and lncRNA LINC01343 in Human Breast Cancer as the Regulator Biomarkers in a Novel ceRNA Network: Based on Bioinformatics and Experimental Analyses
Authors: Rishehri Mehrnoush , Etemadi Tahereh , Pisheh Leila , Koufigar Ghazaleh , Azadeh Mansoureh
Published: September 2022

Breast cancer (BC) is one of the leading cancers in the world, which has become an increasing serious problem. In this context, reports demonstrate that some long noncoding RNAs (lncRNAs) play significant regulatory roles in breast tumorigenesis and BC progression via various pathways and act as endogenous RNAs. Finding their dysregulation in cancer and evaluating their interaction with other molecules, such as short noncoding RNAs “microRNA (miRNAs)” as well as various genes, are the most important parts in cancer diagnostics. In this study, after performing GSEA and microarray analysis on the GSE71053 dataset, a new ceRNA network of CCDC18-AS1, LINC01343, hsa-miR4462, and SFN in BC was detected by bioinformatics analysis. Therefore, the expression of SFN, CCDC18-AS1, and LINC01343 was quantitatively measured in 24 BC and normal paired tissues using qRT-PCR. CCDC18-AS1, LINC01343, and SFN were expressed higher in BC than in the control (normal paired) tissues based on qRT-PCR data. Furthermore, a significant positive correlation was observed between CCDC18-AS1 and LINC01343 expression in the samples investigated in this study. The investigation of clinicopathological parameters showed that SFN was highly expressed in tumor size of <5 cm and in nonmenopausal ages, while CCDC18-AS1 and LINC01343 indicated a high expression in stages II-III and III of BC, respectively. The overall survival analysis displayed high and low survival in patients with high expression of SFN and CCDC18-AS1, respectively. The ROC curve analysis disclosed that SFN, CCDC18-AS1, and LINC01343 might be suggested as potential biological markers in BC patients. The high expression of CCDC18-AS1, LINC01343, and SFN in BC samples suggests their potential role in BC tumorigenesis and could be considered hallmarks for the diagnosis and prognosis of BC, although this will require further clinical investigations.
Machine Learning Computing Migration and Management Based on Edge Computing of Multiple Data Sources in the Internet of Things
Authors: Yin Yudong
Published: September 2022

With the implementation of the concepts of smart city and smart home, the number of user-intelligent terminal devices is increasing. The traditional computing framework cannot meet the increasing data volume and computing needs. Edge computing based on multiple data sources of the Internet of things can not only meet the computing needs of users’ intelligent devices but also reduce energy consumption and user computing waiting time. Therefore, this article puts forward the research on the migration and management of deep reinforcement learning computing based on the edge computing of Internet of things multiple data sources, integrates the deep reinforcement computing technology in the edge computing of Internet of things multiple data sources, and optimizes the edge computing migration scheme and resource allocation management. The test results show that deep reinforcement learning can effectively control the cost of computing migration and enable it to complete computing tasks efficiently while maintaining stable operation. Compared with the traditional enhanced algorithm and the minimum migration scheme, the management model can complete the computing migration task with less energy consumption and shorter average computing waiting time.
Efficient Cervical Cell Lesion Recognition Method Based on Dual Path Network
Authors: Qin Mingwei , Gao Yongxiang , Sun Haifeng , Gou Mingliang , Zhou Ning , Yao Yuancheng
Published: September 2022

Ubiquitous computing and artificial intelligence are widely used in the field of Wise Information Technology of Med. It promotes the development of intelligent diagnosis and treatment, as well as reducing the workload of doctors’ diagnosis and promoting the improvement of the diagnosis level of medical institutions in remote areas. The accurate detection of cervical cytopathy is related to the precise treatment and rehabilitation of patients. However, the low rate of accuracy in the existing cervical cytopathy image detection cannot satisfy the application needs of intelligent diagnosis. In this paper, a dual path network efficient detection method for cervical cytopathy (the proposed DSRNet50) is proposed, which is based on the deep learning method, and combines residual structure and dense connection. The proposed DSRNet50 is mainly based on residual structure, supplemented by dense connection paths, which improves the utilization of features, and maintains the ability of exploring new features by reducing feature redundancy. Meanwhile, the proposed DSRNet50 leverages packet convolution to reduce the computation burden of the network and eliminate the over fitting phenomenon of the network. The proposed DSRNet50 further exploits channel attention mechanism to recalibrate important features to suppress the propagation of irrelevant information. We use the Herlev dataset to verify the proposed DSRNet50 in the terms of the detection accuracy, parameter quantity, and computing complexity. The experiment results are presented to show the achievable performance of the proposed DSRNet50.
Pharmaceutical Reactivation of Attenuated Apoptotic Pathways Leads to Elimination of Osimertinib Drug-Tolerant Cells
Authors: Martin Matthew J. , Floc'h Nicolas , Pfeifer Matthias , Criscione Steven , Delpuech Oona , Gagrica Sladjana , Yao Yi , McDermott Ultan , Smith Paul D.
Published: September 2022

Osimertinib is an EGFR tyrosine kinase inhibitor (TKI) with proven clinical efficacy; however, acquired resistance presents an obstacle to curing EGFR-driven disease. Recent studies have shown that drug-tolerant persister cells (DTP) have a distinct transcriptional profile that may confer specific vulnerabilities. By definition these cells avoid apoptosis, yet little is known about how their survival is regulated. We found that paradoxically, the proapoptotic gene BIM was upregulated in osimertinib DTPs, and cotreatment with BH3 mimetics could trigger DTP cell death. Furthermore, cIAP proteins, antiapoptotic members of the extrinsic pathway, were significantly elevated in DTPs. cIAP antagonists could block DTP formation as an up-front combination, and could eliminate preformed DTPs. Critically, when treated at the time of maximal osimertinib response, cIAP or MCL1 inhibitor treatment could significantly attenuate the regrowth of EGFRm cell line mouse xenografts. Finally, we show that apoptosis can be maximized in cell lines with acquired osimertinib resistance by combining BH3 or SMAC mimetics with agents that target the resistance driver in these models. Taken together, these data suggest novel therapeutic strategies at the point of minimal residual disease or full osimertinib resistance for patients in this critical area of unmet need.

Significance:

These studies uncover strategies to use targeted agents that activate apoptosis in non–small cell lung cancer cells that survive initial EGFR TKI treatment.
Lessons from Four Decades of Systemic Amyloidosis with Renal Involvement
Authors: Oliveira-Silva Catarina , Marques Nídia , Pinho Ana , Poínhos Rui , Bergantim Rui , Nunes Ana Teresa , Sampaio Susana , Rodrigues-Pereira Pedro , Silva Roberto , Praça Augusta , Frazão João , Pestana Manuel , Tavares Isabel
Published: September 2022

Background: Apart from ATTR amyloidosis, the epidemiology and outcomes of the most common subtypes of systemic amyloidosis in Portugal remain primarily unknown. Methods: This retrospective cohort study evaluated patients with renal biopsy-proven amyloidosis, diagnosed from January 1978 to December 2019. Follow-up started at kidney disease presentation and ended at death or August 2020. Clinical presentation, survival, and prognostic factors were analysed. Results: Of 123 patients with amyloid nephropathy, 111 had definite amyloid typing and were analysed. AA amyloidosis was the most frequent type (56.1%) and was related mainly to chronic infection (47.8%) and chronic inflammatory arthritis (29.0%). AL amyloidosis was present in 25.2% of patients and hereditary forms in 6.5% (4.1% AFibE526V, 2.4% ATTRV30M). During follow-up, 73.9% of AA and 54.8% of AL patients progressed to end-stage renal disease, and 79.7% of AA and 77.4% of AL died; median overall survival was 66.0 (95% CI, 33.0–99.0) and 18.0 (95% CI, 9.3–26.7) months (p = 0.025), respectively. There were no significant differences in renal outcome and survival on dialysis between these two types. In multivariate analysis, cardiac involvement at presentation (HR 6.26 [95% CI, 2.89–13.56]) and estimated glomerular filtration rate <30 mL/min/1.73 m2 (HR 2.05 [95% CI, 1.06–3.99]) independently influenced AA and AL amyloidosis survival. Cardiac involvement at presentation was an independent predictor of death (HR 9.65 [95% CI, 2.91–31.95]) and early mortality in AL amyloidosis. Conclusions: In Portugal, AA amyloidosis and related chronic infections are still relevant. Regarding AL amyloidosis, the low incidence and advanced disease at presentation result from missed and erroneous diagnoses, leading to delayed referrals and poor outcomes in these patients.
A Case of Hemophagocytic Lymphohistiocytosis following Second Dose of COVID-19 Vaccination
Authors: Park Hee Won , Min Gi June , Kim Tong Yoon , Cho Seok-Goo
Published: September 2022

Hemophagocytic lymphohistiocytosis (HLH) is a rare, severe hyperinflammatory disease characterized by overproduction of cytokines and hemophagocytosis of hematopoietic cells, resulting in multiorgan failure. Prompt treatment initiation is essential for patient survival. The coronavirus disease 2019 (COVID-19) pandemic has led to the rapid development of several vaccines, including BNT162b2 by Pfizer-BioNTech. Few cases of immune-mediated complications of COVID-19 and its vaccines have been reported, characterized by persistent stimulation of the immune system, resembling HLH. We report the case of a 21-year-old man with secondary HLH following a second dose of the BNT162b2 vaccine. The patient did not have primary HLH or other contributors to secondary HLH and met the HLH-2004 diagnostic criteria. He was safely treated with steroid pulse therapy alone, without etoposide, cyclosporin, or immunoglobulins, which are recommended for pediatric patients. Physicians need to be aware of such severe complications following a second dose of the COVID-19 vaccine.
Conservação de acervos do patrimônio cultural e científico da Universidade de São Paulo em tempos de Covid-19: reflexão sobre ações iniciais e desafios
Authors: Lavezzo Ariane Soeli , Urzua Flávia Andréa Machado , Hergert Ina , Saft Juliana Bechara
Published: September 2022

Este artigo propõe lançar uma reflexão sobre a efetividade das respostas da Universidade de São Paulo (USP) para preservação de seus acervos nas primeiras 12 semanas da emergência provocada pelo novo coronavírus. Para isso, o artigo apresenta o levantamento realizado pelo Grupo de Trabalho de Publicações da Rede de Conservação Preventiva da USP, durante a fase inicial da pandemia, para investigação da capacidade de resposta frente a uma ameaça desconhecida: a pandemia pelo vírus Sars-CoV-2, tendo em vista a saúde das pessoas e a conservação preventiva dos acervos das Unidades da Universidade que lidam com o patrimônio cultural e científico. O texto está dividido em três partes. Na primeira, é apresentado o contexto que influencia na capacidade institucional de gerir situações de emergência: a comunicação, o trabalho em equipe e a resiliência nos processos de transformação. Na segunda parte, tem-se um breve histórico das decisões institucionais (até junho de 2020) e, por fim, na terceira parte, são apresentados e discutidos os resultados do questionário, formulado pela REDE e aplicado a funcionários, docentes e discentes da USP. As respostas indicaram que a USP respondeu prontamente para a salvaguarda da saúde física de sua comunidade, no entanto, encontrou alguma dificuldade para atuar, ágil e eficientemente, na proteção dos funcionários terceirizados, da saúde emocional e dos acervos. O ineditismo desta emergência explica, em parte, as dificuldades enfrentadas, porém, também é preciso levar em conta a ausência, em muitas Unidades, de planos e protocolos claros e de treinamento prévio das equipes frente a ameaças pandêmicas.
Arte e cultura popular na academia: possibilidades de diálogo no acervo do Museu D. João VI
Authors: Lima Carolina Rodrigues de
Published: September 2022

Em 2012, o Museu D. João VI, pertencente à Escola de Belas Artes da Universidade Federal do Rio de Janeiro (UFRJ), recebeu uma coleção de arte popular composta por 1.366 peças de diversas dimensões, materiais e origens. Este artigo pretende refletir sobre o lugar da arte popular em um museu universitário constituído originalmente por coleções acadêmicas compostas por obras de origem europeia ou de tradição ocidental a partir de um breve panorama da trajetória da Coleção Renato Miguez de Arte Popular e os pontos de aproximação entre a constituição desse sistema de representação e os saberes construídos dentro da universidade.
O Museu Nacional e a constituição da SAE: aspectos históricos de sua função educativa
Authors: Souza Fernanda de Lima , Gomes Maria Margarida
Published: September 2022

O presente artigo tem como objetivo discutir evidências sobre a constituição social e histórica da função educativa da Seção de Assistência ao Ensino (SAE) do Museu Nacional. Dialogando tanto com contribuições do campo do currículo relacionadas a estudos sobre as disciplinas escolares como também com literatura da área de educação em museus, busca-se argumentar sobre a importância da produção de coleções didáticas por esse setor e a respeito da construção da relação com as instituições escolares. Assim, procura-se trazer indícios sobre dois momentos marcantes da história dessa seção: a sua criação nas décadas de 1920-1930 e a socialização de objetos da coleção didática zoológica da SAE no tempo presente. Para isso, são articulados para análise trabalhos bibliográficos, relatórios sobre suas atividades e trechos de entrevistas com professores de ciências e biologia que vêm utilizando exemplares dessa coleção didática de zoologia. Desse modo, apresentam-se reflexões sobre aspectos sócio-históricos determinantes para a constituição dessa seção. Além disso, mostra-se como a relação do Museu Nacional com as escolas vem sendo construída ao longo de sua história a partir de mediações que incluem a produção e disponibilização das coleções didáticas de ciências da SAE.
A criação do Sistema de Museus, Acervos e Patrimônio Cultural da UFRJ (Simap): desdobramentos de uma política cultural universitária
Authors: Lima Deborah Rebello , Carvalho Claudia Rodrigues , Garcia Patricia Regina Santos
Published: September 2022

O artigo apresenta o processo de criação do Sistema de Museus, Acervos e Patrimônio Cultural da Universidade Federal do Rio de Janeiro (Simap-UFRJ), colocando em perspectiva esse modelo de gestão e a vinculação política pela qual é sustentado. A estrutura metodológica se apoia em um breve debate bibliográfico sobre a questão dos museus universitários e da  área cultural nas Instituições Federais de Ensino Superior (Ifes), por meio do exemplo da UFRJ. Soma-se a isso um pequeno resgate da história recente do tema na instituição e a tentativa de entender como o Simap vem desenvolvendo suas ações desde seu surgimento. A despeito dos desafios, a atuação do Simap vem ampliando a visibilidade política de museus e espaços científico-culturais dentro da própria universidade, criando condições que permitem concretizar mais mudanças, ainda que a longo prazo, ao incentivar não somente o aporte de recursos, mas, também, novas relações entre esses equipamentos e a estrutura universitária.
Pseudorobillarda sichuanensis sp. nov. associated with Bambusa sp. from Sichuan province, China
Authors: SONG JING-YI , TIAN QING , LIU JIAN‑KUI
Published: September 2022

During an investigation of ascomycetous fungi on bamboos in Sichuan province, China, a new coelomycetous species, Pseudorobillarda sichuanensis was found on dead culms of Bambusa sp. and described. The new taxon differs from other Pseudorobillarda species in having paraphyses, subcylindrical conidiogenous cells, subcylindrical to naviculate, aseptate, guttulate conidia with 3-4 apical appendages. Phylogenetic analyses of a combined internal transcribed spacer (ITS), the partial 28S large subunit rDNA (LSU), the partial 18S small subunit rDNA(SSU) and the partial DNA-directed RNA polymerase II subunit (rpb2) sequence data showed that P. sichuanensis has a close phylogenetic affinity to P. texana. A novel bambusicolous fungi of Pseudorobillarda is described, illustrated and notes on its identification are provided.
Revision of the South American Ceratognathini (Coleoptera: Lucanidae: Aesalinae) with the description of a new genus and a new species
Authors: PAULSEN M. J. , E. JOSÉ MONDACA
Published: September 2022

We examine the taxonomic placement of the South American stag beetles of the tribe Ceratognathini Sharp, 1899 that were previously placed in the genus Ceratognathus Westwood. We compared the South American species with specimens from 13 species of Australasian Ceratognathini using morphological characters of the legs, mandibles, genitalia, and elytra. Based on generic limits proposed by Holloway for the Australasian Ceratognathini, the South American species differ from the three Australasian genera (Ceratognathus, Mitophyllus Parry, and Holloceratognathus Nikolajev) sufficiently to establish a new genus, Hilophyllus n. gen. The South American taxa are transferred to the new genus, resulting in two new combinations: Hilophyllus argentinensis (Martínez) and H. penai (Martínez). During our study of the Neotropical species we discovered a third species (H. martinezi, n. sp.), which is described here as new. To maintain nomenclatural stability we designate a neotype for H. argentinensis, the holotype of which is lost. The two previously known species of Hilophyllus are redescribed and a key to Hilophyllus species is provided.
The larva of Alpopsyche ucenorum (McLachlan 1876) (Trichoptera: Limnephilidae) with notes on its systematic position and ecology
Authors: WARINGER JOHANN , BOTOSANEANU LAZARE , LE GUELLEC GWENOLE
Published: September 2022

The paper gives a description of the hitherto unknown larva of Alpopsyche ucenorum (McLachlan 1876). Information on the morphology of this larva is given and the most important diagnostic features are illustrated. In the context of already available keys, the larva of Alpopsyche keys together with Allogamus uncatus (Brauer). The 2 species may be separated by the larger head width of A. uncatus and the position for the beginning of the lateral fringe (A. ucenorum: 3rd abdominal segment, A. uncatus: 2nd segment). With respect to zoogeography, A. uncatus is widely distributed in Europe whereas A. ucenorum is restricted to the western Alps. In addition, ecological facts are summarized and the systematic position within Limnephilidae is discussed.
On sand-bearing myxillid sponges, with a description of Psammochela tutiae sp. nov. (Poecilosclerida, Myxillina) from the northern Moluccas, Indonesia
Authors: DE VOOGD NICOLE J.
Published: September 2022

Sand-bearing sponges belonging to the suborder Myxillina are mainly observed in South Australia. Recent biodiversitysurveys in Indonesia yielded several of these sand-bearing sponges belonging to three different genera, Chondropsis, Des-mapsamma and Psammochela. These sponges are distributed across three different families and the ecological and evo-lutionary implications for the incorporation of sand and detritus in the skeleton remain unresolved so far. In the presentpaper Psammochela tutiae sp.nov. (Poecilosclerida: Myxillina: Myxillidae) is described from the northern Moluccas, In-donesia. The new species is compared with all other (five) Psammochela species occurring in the Indo-West Pacific. Thenew species differs from the other species by overall morphology, absence of polydentate chelae and presence of thinstrongylote megascleres. The current position of Psammochela within the Myxillidae and its relation to other arenaceous Myxillina are discussed here, and an identification key to all known species of Psammochela is given.
The Agononida incerta species complex unravelled (Crustacea: Decapoda: Anomura: Munididae)
Authors: POORE GARY C. B. , ANDREAKIS NIKOS
Published: September 2022

Squat lobsters from Australia, east Africa, Taiwan, Philippines and the Norfolk Ridge (southwestern Pacific) previouslyidentified as Agononida incerta (Henderson, 1888) are redescribed as four new species in addition to the original: A.africerta, A. auscerta, A. indocerta and A. norfocerta. A. rubrizonata Macpherson & Baba, 2009, also earlier confusedwith this species, is redescribed. All six species are morphologically distinguishable only on the basis of the shape of theanterolateral lobe of the telson and the shape and setation of the dactyli of pereopods 2–4. The morphological delineationof these species and their taxonomic status are robustly supported by phylogenetic analysis of the partial mitochondrialCOI marker. Taken together, subtle morphological differences, geographical distribution patterns and genetic discontinuities have important implications for understanding diversity, systematics and evolution of squat lobsters.
Revision of the genus Amytta (Orthoptera: Tettigoniidae, Meconematinae) and new species from East Africa
Authors: HEMP CLAUDIA , HELLER KLAUS-GERHARD
Published: September 2022

New species of Amytta are described from East Africa. Beside tegminal length, they differ mainly in the structure of the complicated male genitalic organs, notably the last abdominal tergite and cerci. Data on habitat and the acoustics of some species and a key to the species are provided. The songs of all seven Amytta species studied are very similar, consisting of long trills with a syllable repetition rate of about 60 Hz (at 20ºC) and a broad frequency peak in the ultrasound at around 40 kHz. The biogeographic pattern and phylogenetic relationships are discussed for the group.
Revision of the spider genus Nyetnops Platnick & Lise (Araneae: Caponiidae) with proposition of the new genus Nopsma, from Central and South America
Authors: SÁNCHEZ-RUIZ ALEXANDER , BRESCOVIT ANTONIO D. , BONALDO ALEXANDRE B.
Published: September 2022

The singular spider genus Nyetnops Platnick & Lise is revised and three new species are described from Peru (Nyetnops naylienae n. sp.), Bolivia (Nyetnops lachonta n. sp.) and Brazil (Nyetnops buruti n. sp.). An updated diagnosis is proposed for the type species Nyetnops guarani Platnick & Lise and new records from the Brazilian State of São Paulo are presented for this species. The Ecuadorian species Nyetnops juchuy Dupérré is elected as the type species of a new genus herein proposed (Nopsma n. gen.), which also harbors three other new species from Peru (Nopsma enriquei n. sp.), Colombia (Nopsma florencia n. sp.) and Nicaragua (Nopsma armandoi n. sp.).
Taxonomy of widespread Neotropical species of Podisus Herrich-Schäffer
(Hemiptera: Pentatomidae: Asopinae): redescription of P. distinctus (Stål, 1860) and revalidation of P. fuscescens (Dallas, 1851)
Authors: BRUGNERA RICARDO , ROELL TALITA , CAMPOS LUIZ ALEXANDRE , GRAZIA JOCELIA
Published: September 2022

Some species of Podisus Herrich-Schäffer have a confuse taxonomic history with several modifications and loss of information over time. The genus has been considered a taxonomic dumping ground in Asopinae, and its current species composition is doubtful. After examining the type specimens of Telepta distincta Stål, Arma submarginata Walker, Arma monospila Walker, Arma fuscescens Dallas, Arma caliginosa Walker, Arma turbida Walker and Podisus mellipes Bergroth, we redescribe and revalidate A. fuscescens as Podisus fuscescens rev. stat., previously considered a junior synonym of Podisus sagitta (Fabricius). The taxonomic status, morphology and distribution of P. fuscescens and P. distinctus are updated and illustrated. Arma caliginosa, A. turbida and Podisus mellipes become synonyms of P. fuscescens. Additionally, Arma submarginata Walker is removed from its synonymy with Podisus ventralis (Dallas) and treated as a synonym of P. distinctus. Podisus signoreti Fallou is removed from its synonymy with P. distinctus and treated as species inquirenda.
Peri–CAR-T practice patterns and survival predictors for all CAR-T patients and post–CAR-T failure in aggressive B-NHL
Authors: Zurko Joanna , Nizamuddin Imran , Epperla Narendranath , David Kevin , Cohen Jonathon B. , Moyo Tamara K. , Ollila Thomas , Hess Brian , Roy Ishan , Ferdman Robert , Liu Jieqi , Chowdhury Sayan Mullick , Romancik Jason , Bhansali Rahul S. , Harris Elyse I. , Sorrell Mckenzie , Masel Rebecca , Kittai Adam S. , Denlinger Nathan , Sigmund Audrey M. , Fitzgerald Lindsey , Galvez Carlos , Ma Shuo , Winter Jane , Pro Barbara , Gordon Leo I. , Danilov Alexey , Stephens Deborah , Shah Nirav N. , Kenkre Vaishalee , Barta Stefan K. , Torka Pallawi , Shouse Geoffrey , Karmali Reem
Published: September 2022

Most patients receiving chimeric antigen receptor T-cell therapy (CAR-T) for aggressive B-cell non-Hodgkin lymphoma (B-NHL) do not experience a durable remission. Several novel agents are approved to treat relapsed, refractory aggressive B-NHL; however, it remains unclear how to sequence these therapies pre– and post–CAR-T. We conducted a multicenter retrospective analysis to describe peri–CAR-T practice patterns and survival predictors for patients receiving CD19-directed CAR-T. Patients (n = 514) from 13 centers treated with CAR-T for B-NHL between 2015-2021 were included in the study. Survival curves were constructed using Kaplan-Meier method. Multivariate Cox regression analysis was used to determine the impact of the variables on survival outcomes. For all patients receiving CAR-T, a greater number of lines of therapy pre-CAR-T apheresis and bridging therapy were predictive of inferior progression-free survival (PFS) and overall survival (OS). The median PFS and OS from the time of CAR-T cell infusion were 7.6 and 25.6 months, respectively. From the time of progression post–CAR-T, the median OS was 5.5 months. The median PFS of treatments administered in the first-line post–CAR-T failure was 2.8 months. Patients with refractory disease on day 30 had inferior OS and were less likely to receive subsequent treatment(s) than other patients with CAR-T failure. Allogeneic hematopoietic cell transplantation for selected patients at any time following CAR-T failure led to durable responses in over half of patients at 1 year. These data provide a benchmark for future clinical trials in patients with post–CAR-T cell progression, which remains an unmet clinical need.
Gray and white matter structural examination for diagnosis of major depressive disorder and subthreshold depression in adolescents and young adults: a preliminary radiomics analysis
Authors: Ma Huan , Zhang Dafu , Sun Dewei , Wang Hongbo , Yang Jianzhong
Published: September 2022

Background

Radiomics is an emerging image analysis framework that provides more details than conventional methods. In present study, we aimed to identify structural radiomics features of gray matter (GM) and white matter (WM), and to develop and validate the classification model for major depressive disorder (MDD) and subthreshold depression (StD) diagnosis using radiomics analysis.

Methods

A consecutive cohort of 142 adolescents and young adults, including 43 cases with MDD, 49 cases with StD and 50 healthy controls (HC), were recruited and underwent the three-dimensional T1 weighted imaging (3D-T1WI) and diffusion tensor imaging (DTI). We extracted radiomics features representing the shape and diffusion properties of GM and WM from all participants. Then, an all-relevant feature selection process embedded in a 10-fold cross-validation framework was used to identify features with significant power for discrimination. Random forest classifiers (RFC) were established and evaluated successively using identified features.

Results

The results showed that a total of 3030 features were extracted after preprocessing, including 2262 shape-related features from each T1-weighted image representing GM morphometry and 768 features from each DTI representing the diffusion properties of WM. 25 features were selected ultimately, including ten features for MDD versus HC, eight features for StD versus HC, and seven features for MDD versus StD. The accuracies and area under curve (AUC) the RFC achieved were 86.75%, 0.93 for distinguishing MDD from HC with significant radiomics features located in the left medial orbitofrontal cortex, right superior and middle temporal regions, right anterior cingulate, left cuneus and hippocampus, 70.51%, 0.69 for discriminating StD from HC within left cuneus, medial orbitofrontal cortex, cerebellar vermis, hippocampus, anterior cingulate and amygdala, right superior and middle temporal regions, and 59.15%, 0.66 for differentiating MDD from StD within left medial orbitofrontal cortex, middle temporal and cuneus, right superior frontal, superior temporal regions and hippocampus, anterior cingulate, respectively.

Conclusion

These findings provide preliminary evidence that radiomics features of brain structure are valid for discriminating MDD and StD subjects from healthy controls. The MRI-based radiomics approach, with further improvement and validation, might be a potential facilitating method to clinical diagnosis of MDD or StD.
Association between cognition and color discrimination among Lebanese patients with schizophrenia
Authors: Dahdouh Oussama , Solh Tala , Lahoud Corinne , Haddad Chadia , Hallit Souheil
Published: September 2022

Background

Patients with schizophrenia (SCZ) exhibit poorer color discrimination than normal individuals. Although retinal abnormalities, as well as cortical and subcortical alterations, found in patients with SCZ have been suggested to cause this poor color discrimination, the impact of cognitive impairment remains to be determined. Dopamine (DA) and glutamate (Glu), known to be disrupted in SCZ, are also suggested to play a role in color discrimination. Our objective was to investigate the contribution of cognitive impairment to color discrimination deficits in SCZ and to examine if these deficits are correlated to SCZ symptoms.

Methods

This study includes 127 patients with SCZ between July and September 2021. The participants completed several questionnaires, specifically the Positive and Negative Syndrome Scale (PANSS), the Montreal Cognitive Assessment (MoCA) test, and the Farnsworth D-15 test, to assess the extent of SCZ symptoms, cognition, and color discrimination respectively.

Results

Higher cognition (Beta = − 0.279) was significantly associated with a lower total error score (TES). Moreover, a higher positive PANSS score (Beta = 0.217) was significantly associated with a higher TES. A multinomial regression analysis taking the type of color blindness as the dependent variable showed that female sex (ORa = 5.46) was significantly associated with a certain type of color blindness.

Conclusion

Color discrimination deficits in patients with SCZ may be due to the effect of cognitive impairment and/or SCZ itself.
The role of Savings and Internal Lending Communities (SILCs) in improving community-level household wealth, financial preparedness for birth, and utilization of reproductive health services in rural Zambia: a secondary analysis
Authors: Lee Ha Eun , Veliz Philip T. , Maffioli Elisa M. , Munro-Kramer Michelle L. , Sakala Isaac , Chiboola Nchimunya M. , Ngoma Thandiwe , Kaiser Jeanette L. , Rockers Peter C. , Scott Nancy A. , Lori Jody R.
Published: September 2022

Background

Savings and Internal Lending Communities (SILCs) are a type of informal microfinance mechanism widely adapted in Zambia. The benefits of SILCs paired with other interventions have been studied in many countries. However, limited studies have examined SILCs in the context of maternal health. This study examined the association between having access to SILCs and: 1) household wealth, 2) financial preparedness for birth, and 3) utilization of various reproductive health services (RHSs).

Methods

Secondary analysis was conducted on baseline and endline household survey data collected as part of a Maternity Waiting Home (MWH) intervention trial in 20 rural communities across seven districts of Zambia. Data from 4711 women who gave birth in the previous year (baseline: 2381 endline: 2330) were analyzed. The data were stratified into three community groups (CGs): CG1) communities with neither MWH nor SILC, CG2) communities with only MWH, and CG3) communities with both MWH and SILC. To capture the community level changes with the exposure to SILCs, different women were randomly selected from each of the communities for baseline and endline data, rather than same women being surveyed two times. Interaction effect of CG and timepoint on the outcome variables – household wealth, saving for birth, antenatal care visits, postnatal care visits, MWH utilization, health facility based delivery, and skilled provider assisted delivery – were examined.

Results

Interaction effect of CGs and timepoint were significantly associated only with MWH utilization, health facility delivery, and skilled provider delivery. Compared to women from CG3, women from CG1 had lower odds of utilizing MWHs and delivering at health facility at endline. Additionally, women from CG1 and women from CG2 had lower odds of delivering with a skilled provider compared to women from CG3.

Conclusion

Access to SILCs was associated with increased MWH use and health facility delivery when MWHs were available. Furthermore, access to SILCs was associated with increased skilled provider delivery regardless of the availability of MWH. Future studies should explore the roles of SILCs in improving the continuity of reproductive health services.

Trial registration

NCT02620436.
Comparison of obesity-related indicators for identifying metabolic syndrome among normal-weight adults in rural Xinjiang, China
Authors: Jian Le-yao , Guo Shu-xia , Ma Ru-lin , He Jia , Rui Dong-sheng , Ding Yu-song , Li Yu , Sun Xue-ying , Mao Yi-dan , He Xin , Liao Sheng-yu , Guo Heng
Published: September 2022

Background

This study aimed to compare the ability of certain obesity-related indicators to identify metabolic syndrome (MetS) among normal-weight adults in rural Xinjiang.

Methods

A total of 4315 subjects were recruited in rural Xinjiang. The questionnaire, biochemical and anthropometric data were collected from them. Binary logistic regression was used to analyze the association between the z-score of each index and MetS. The area under the receiver-operating characteristic (ROC) curves were used to compare the diagnostic ability of each index. According to the cut-off value of each index, nomogram models were established and their diagnostic ability were evaluated.

Results

After adjusting for confounding factors, each indicator in different genders was correlated with MetS. Triglyceride-glucose index (TyG index) showed the strongest association with MetS in both males (OR = 3.749, 95%CI: 3.173–4.429) and females (OR = 3.521,95%CI: 2.990–4.148). Lipid accumulation product (LAP) showed the strongest diagnostic ability in both males (AUC = 0.831, 95%CI: 0.806–0.856) and females (AUC = 0.842, 95%CI: 0.820–0.864), and its optimal cut-off values were 39.700 and 35.065, respectively. The identification ability of the TyG index in different genders (males AUC: 0.817, females AUC: 0.817) was slightly weaker than LAP. Waist-to-height ratio (WHtR) had the similar AUC (males: 0.717, females: 0.747) to conicity index (CI) (males: 0.734, females: 0.749), whereas the identification ability of a body shape index (ABSI) (males AUC: 0.700, females AUC: 0.717) was relatively weak. Compared with the diagnostic ability of a single indicator, the AUC of the male nomogram model was 0.876 (95%CI: 0.856–0.895) and the AUC of the female model was 0.877 (95%CI: 0.856–0.896). The identification ability had been significantly improved.

Conclusion

LAP and TyG index are effective indicators for identifying MetS among normal-weight adults in rural Xinjiang. Nomogram models including age, CI, LAP, and TyG index can significantly improve diagnostic ability.
Evaluating the influence of financial investment in compulsory education on the health of Chinese adolescents: a novel approach
Authors: Yang Kewen , Fahad Shah , Yuan Feimin
Published: September 2022

Background

With China's aging and declining fertility rate, the importance of population quality is increasing. As the main force of the labor market in the future, the Chinese government tries to promote the development of adolescents by increasing the financial investment in compulsory education, so as to improve the future population quality of China and enhance the national competitiveness. Therefore, the aim of this study was to investigate the relationship between financial investment in compulsory education and the health of Chinese adolescents.

Methods

This study specifically uses data obtained from China Education Panel Survey (CEPS). The data were nationally representative, which covered families, schools, and communities. For the CEPS data obtained, the 2013–2014 school year was the baseline, and two cohorts of 7th and 9th graders were the starting point of the survey. In the 2014–2015 school year, 8th-grade students who participated in the baseline survey (7th-grade students in the 2013–2014 school year) were followed up. Since the second period only began to investigate the data on financial investment in compulsory education, this article uses the data from the 2014–2015 academic year for research. OLS and Ordered Probit models were used to investigate the impact of financial investment in compulsory education on adolescent health.

Results

With the doubling of financial investment in compulsory education, self-rated health increased by 0.021, frequency of illness decreased by 0.03, the number of sick leave days decreased by 0.207, and depression decreased by 0.191. The heterogeneity analysis shows that compared to only-child, high-income and nonagricultural groups, the financial investment in compulsory education has a greater impact on the health of adolescents with the characteristics of agriculture hukou, non-only-child and low-income families. Further analysis of the impact mechanism shows that financial investment in compulsory education exerts a significant influence on the health of adolescents by easing family budget constraints, improving school sports facilities, and increasing the expected return of health investment and social capital.

Conclusions

Financial investment in compulsory education can enhance the health of adolescents, and vulnerable groups benefit more, which is conducive to promoting health equity.