bluuebunny/crossref_metadata_2025 huggingface dataset:
Perencanaan Pengembangan Alumni Perguruan Tinggi dalam Perspektif Islam
Authors: Rahayu Anissa Maila , Mujahidin Endin , Handrianto Budi
Published: September 2021

The planning preparation of an activity is highly recommended in Islamic perspective. The completion of university’s study program does not make the university complete its planning task. The existence of alumni as a necessity of the educational process has an important position and role in Islamic civilization and requires seriousness in planning its development. Currently, exploring concepts from an Islamic perspective is still limited, especially in terms of alumni development. The purpose of this study is to describe the concept of alumni in an Islamic perspective and to explain the planning of alumni development in the university. This study uses a qualitative approach with library research. The results of this study are (1) the term ‘alumni’ in the Islamic perspective refers to a monumental event and (2) alumni development planning can use the POAC (planning, organizing, actuating, controlling) concept by George Robert Terry where the stages of the flow start from planning, then organizing, then mobilizing and finally monitoring. After knowing the role of alumni is very strategic, it is hoped that alumni development planning in the future will be managed properly and seriously.

Abstrak

Penyusunan suatu perencanaan kegiatan sangatlah dianjurkan dalam perspektif Islam. Selesainya program pendidikan tinggi tidaklah menjadikan perguruan tinggi tersebut selesai dalam tugas perencanaannya. Keberadaan alumni sebagai satu keniscayaan dari adanya proses pendidikan mempunyai posisi dan peran penting terhadap peradaban Islam dan perlu keseriusan dalam perencanaan pengembangannya. Saat ini, penggalian konsep dari perspektif Islam masih terbatas khususnya dalam hal pengembangan alumni. Tujuan penelitian ini adalah untuk mendeskripsikan konsep alumni dalam perspektif Islam dan menjelaskan perencanaan pengembangan alumni di perguruan tinggi. Penelitian ini menggunakan pendekatan kualitatif dengan kepustakaan. Hasil dari penelitian ini adalah (1) istilah ‘alumni’ dalam perspektif Islam merujuk kepada kejadian yang monumental dan (2) perencanaan pengembangan alumni dapat menggunakan konsep POAC (planning, organizing, actuating, controlling) oleh George Robert Terry yang mana tahapan alurnya dimulai dari perencanaan, lalu pengorganisasian, kemudian penggerakan dan terakhir pengawasan. Setelah mengetahui peran alumni sangat strategis, maka diharapkan perencanaan pengembangan alumni kedepannya dikelola dengan baik dan serius.
Konsep Kesehatan Mental Remaja dalam Perspektif Islam
Authors: Hamidah Rizka Nur , Rosidah Noneng Siti
Published: September 2021

The concept of mental health in adolescents is very important to understand, especially from an Islamic perspective. Because teenagers are vulnerable to an identity crisis, so the concept of mental health from an Islamic perspective can be the basis for teenagers in thinking and behaving. Therefore, this study aims to make individuals, especially teenagers, aware of how to maintain mental health and what changes occur during adolescence by exploring Islamic education patterns that are in accordance with the Qur'an and Sunnah. The research method used is library research. Retrieval of sources of date and information obtained through journals, books, newspaper or online information, and other sources. Based on the result of the search and date analysis, it can be concluded that the mental health of adolescents in an Islamic perspective, at least they can already know and implement worship practices according to Islamic teachings, are able to face various problems in life. Can adapt to changes new, establish a good relationship with the surrounding environment and strengthen the relationship with God.AbstrakKonsep kesehatan mental diusia remaja penting untuk dapat dicapai dalam prespektif Islam. Sehingga penelitian ini bertujuan untuk dapat membuat semua individu dapat tersadarkan mengenai kesehatan mental yang terjadi dalam usia remaja dan dapat pula mengetahui apa saja perubahan kondisi dalam usia remaja dan juga dapat menerapkan pola pendidikan Islam yang sesuai dengan Al-Qur'an dan As-Sunnah. Metode penelitian yang dilakukan adalah studi keperpustakaan ( library research) ) dengan jenis pendekatan pendekatan, dimana melakukan pengambilan sumber data dan informasi melalui jurnal, buku, artikel dsb.Kemudian pembahasan ini peneliti mengulas kembali dari hasil jurnal yang ditulis oleh Subur pada tahun 2006 yang berjudul "peran pendidikan agama Islam dalam perkembangan jiwa remaja”. Berdasarkan hasil penelitian sebelumnya bahwa dapat dikatakan usia remaja seharusnya dapat mengetahui dalam penerapan praktik-praktik ibadah, dapat mengahadapi berbagai permasalahan yang dialaminya, dapat beradaptasi dengan perubahan-perubahan baru, menjalin hubungan yang baik dengan lingkungan sekitar lalu yang terpenting adalah mempererat hubungan dengan Tuhan. Sehingga hal tersebut dapat dikatakan kesehatan mental remaja yang baik dan sesuai dengan prespektif agama Islam.
Strategi Pusaka Sakinah dalam Menjawab Tantangan Ketahanan Keluarga dalam Permasalahan Pernikahan Dini
Authors: Mustaqim Zaenal , Tamam Abas Mansur , Rahman Imas Kania
Published: September 2021

Family resilience is an important factor in human development. Various ways can be done to build it. Pre-marital guidance is an effort to answer the problem of family resilience. This study aims to describe the form of the family resilience program at the Ciawi Religious Affairs Office and its suitability in addressing the problem of family resilience, which in this case is the problem of early marriage. This type of research is qualitative research with an analytic study approach. This study resulted in the findings that of the three family resilience programs in the KUA Ciawi, the Pusaka Sakinah program has steps that lead to overcoming the problem of early marriage in the form of cross-sectional services, where the KUA can work together with schools. By aligning pre-marital guidance with the school curriculum to provide an understanding of everything related to early marriage. And to realize the cooperation of the Ciawi KUA with the school, a clear, systematic, and directed program is needed that has not been stated concretely in the implementation instructions for the Sakina Heritage. This research is expected to generate new ideas or strategies in an effort to increase family resilience through the Pusaka Sakinah program.

Abstrak                                  

Ketahanan keluarga merupakan faktor penting dalam membangun manusia. Berbagai pihak telah brusaha melakukan kearah sana. Bimbingan pra-nikah adalah salah satu usaha untuk menjawab permasalahan ketahanan keluarga. Penelitian ini bertujuan mendeskripsikan bentuk program ketahanan keluarga di Kantor Urusan Agama Ciawi yang salah satunya adalah Pusaka Sakinah dan kesesuiannya dalam menjawab permasalahan ketahanan keluarga, yang dalam hal ini adalah masalah pernikahan dini. Jenis penelitian yang digunakan adalah penelitian kualitatif dengan pendekatan studi analitik. Penelitian ini menghasilkan temuan bahwa dari tiga program ketahanan keluarga yang ada di KUA kecamatan Ciawi, program Pusaka Sakinahlah yang memiliki langkah yang mengarah pada mengatasi masalah pernikahan dini berupa layanan lintas sektroal, dimana KUA dapat bekerajasama dengan sekolah. Dengan cara menyelaraskan bimbingan pra-nikah dengan kurikulum sekolah untuk memberikan pemahaman tentang segala yang terkait dengan peranikahaan lebih dini. Dan untuk mewujudkan kerjasama KUA kecamatan Ciawi dengan pihak sekolah ini diperlukan program yang jelas terinci, sistematis dan terarah yang belum disebutkan secara kongkrit dalam petunjuk pelaksanaan Pusaka Sakina tersebut.  Dari penelitian ini diharapkan melahirkan ide atau strategi baru dalam usaha meningkatkan ketahana keluarga melalui program Pusaka Sakinah
Resistance inducers and organic fertilizer in Citrus sinensis [L.] Osbeck infected with Candidatus Liberibacter asiaticus bacteria
Authors: Zapata Contreras Yazmin , Osorio Hernandez Eduardo , Silva Espinosa José Hugo , Saénz Pérez Criseida Alhelí , Segura Martínez Ma. Teresa de Jesús
Published: September 2021

Objective: To evaluate the effect of three resistance inducers and an organic fertilizer on the titles of CandidatusLiberibacter asiaticus in Citrus sinensis (L.) Obseck cv. Valencia.Design/methodology/approach: The treatments consisted of Vacciplant Max and UPL-08, Fosetil aluminum. Likewise, BIO-FOM was applied on the periphery of the trees, with moisture for nutrients absorption. The evaluated variables were fruit weight, equatorial diameter, skin thickness, °BRIX, severity and chlorophyll, in each of the five treatments, which consisted of 20 repetitions.Results: The fruits of the trees treated with Vacciplant Max had lower skin thickness and a higher °BRIX. Also, the highest chlorophyll index was recorded with BIO-FOM fertilizer. However, none of the evaluated treatments significantly decreased the fruit harshness.Findings/conclusions: The best treatment against Huanglongbing was fosetyl aluminum which conferred greater fruit weight and diameter
Reproductive activity of dairy cattle in the postpartum anestrus period
Authors: González-Maldonado J. , Pérez Hernández P. , Salazar Ortiz J. , Cortez Romero C. , Gallegos-Sánchez J. , García-Winder Miguel Jorge
Published: September 2021

Objective: To review the metabolic and hormonal processes that regulate reproductive activity in dairy cattleduring the postpartum anestrus period.Design/methodology/approach: Analysis of scientific documents and systematization of information relatedto the reproductive physiology and management of dairy cattle in postpartum anestrus.Results: Postpartum anestrus is an event that occurs naturally and is necessary for restoration of the homeostasisof the cow’s body following calving. However, failure to reestablish this homeostasis actually increases itsduration and negatively affects the subsequent reproductive performance of the individual cow.Limitations on study/implications: Reproductive management decisions must be based on scientificknowledge.Findings/conclusions: Management of dairy cattle in the postpartum anestrus period should focus onreestablishment of the state of homeostasis and the subsequent reproductive activity, with nutritional andhormonal strategies implemented to induce cyclicity, ovulation and formation of the first corpus luteum in thatperiod, through application of exogenous hormones after day ten postpartum.
Competition in the Canadian Telecommunication Industry : Past, Present and Potential Ways Forward
Authors: Hudes Kevin
Published: September 2021

Undoubtedly, the Canadian telecommunications industry is at a critical juncture with respect to competition. Telecommunications services are becoming increasingly essential for Canadian citizens to effectively participate in the economy, democracy and society more broadly. As such, it is critical to explore the various policy mechanisms that can deliver all Canadians an affordable and high quality experience as mandated in section seven of the Telecommunications Act. The study focuses on potential ways to cultivate a meaningfully competitive telecommunications environment that can better represent public interest. Drawing on a litany of international and domestic regulatory decisions, both past and present, in conjunction with academic journals, Candian Radio-television and Telecommunication Commission (CRTC) regulatory proceedings and contemporary news articles, the paper demonstrates that the lack of meaningful competition in the Canadian telecommunications industry is limiting positive outcomes for Canadian citizens in regards to affordability, choice and coverage.
ІГРОВИЙ ГЕНЕЗИС СУЧАСНОГО ПРОТИБОРСТВА У ВОЄННІЙ СФЕРІ
Authors: Хайрулін О.
Published: September 2021

Досліджено феномен гри як генетичного джерела і програми діяльності суб’єкта за складних обставин конкурентної боротьби, включно воєнного протиборства. Обґрунтовано доцільність застосування у дослідженні закономірностей протиборства у воєнній сфері логіки та принципів постнекласичної наукової раціональності. Конкретизовано ігрові аспекти діяльності людини і соціальної групи в сучасних умовах конкуренції, зокрема в умовах ведення інформаційної боротьби.
ПРОБЛЕМИ СТАНОВЛЕННЯ ОСОБИСТОСТІ В УМОВАХ ҐЕНДЕРНОЇ ДЕПРИВАЦІЇ
Authors: Кізь О.
Published: September 2021

У статті представлено теоретичний аналіз проблем становлення особистості в ході ґендерної соціалізації на різних вікових етапах набуття ґендерної ідентичності. Розкрито дефініцію «ґендерна депривація» на прикладі двох агентів ґендерної соціалізації: батьківської сім᾽ї та закладів освіти. Охарактеризовано чинники сімейного та освітнього середовища, що здійснюють депривуючий вплив на учасників ґендерних взаємин у системах «педагог-вихованець», «учитель-учень», «батьки-діти» через дію ґендерних упереджень, ґендерних стереотипів та ґендерних настановлень, наявних у свідомості та відображених у поведінці суб’єктів батьківсько-дитячої та педагогічної взаємодії.
ФЕНОМЕН РОЗВИТКУ ЕМПАТІЇ ОСОБИСТОСТІ У ПЕРІОД ДОРОСЛІШАННЯ: СОЦІАЛЬНО-ПСИХОЛОГІЧНИЙ АСПЕКТ
Authors: Ніколаєв Л. , Скляренко С.
Published: September 2021

У статті представлено результати теоретичного аналізу феномену «емпатії», проаналізовано особливості розвитку та прояву його в підлітковому віці, емпіричного дослідження психологічних особливостей розвитку емпатії в період дорослішання.
ПСИХОЛОГІЧНІ ЧИННИКИ ОСОБИСТІСНОЇ РЕСУРСНОСТІ СТУДЕНТСЬКОЇ МОЛОДІ ПІД ЧАС ДИСТАНЦІЙНОГО НАВЧАННЯ
Authors: Свідерська О. , Демид В.
Published: September 2021

Досліджуються психологічні чинники особистісної ресурсності студентської молоді під час дистанційного навчання. Основними факторами негативного впливу визначено постійне відчуття відсутності сил та енергії, відчуття покинутості, ізоляція, відчуття самотності, та ін.
THE VALUE OF HEALTH ECONOMICS AND OUTCOMES RESEARCH IN PROSTHETICS AND ORTHOTICS
Authors: Miller Taavy , Wurdeman Shane , Paul Rajib , Forthofer Melinda
Published: September 2021

The demand has increased for evidence regarding the effectiveness and value of prosthetic and orthotic rehabilitation interventions. Clinicians and managers are under pressure to provide treatment recommendations and demonstrate effectiveness through outcomes. It is often assumed that rehabilitation interventions, including the provision of custom-made and custom-fit orthotic and prosthetic devices, are beneficial to patients. Assessing the value of orthotic and prosthetic services has become more critical to continue to ensure equitable access to needed services. Health economics and outcomes research methods serve as tools to gauge the value of prosthetic and orthotic rehabilitation interventions. The purpose of this article is to provide an overview of the current need of health economics and outcomes research in orthotics and prosthetics, to introduce common economic methods that assist to generate real-world evidence, and to discusses the potential value of economic methods for clinicians and clinical practice.

Article PDF Link: https://jps.library.utoronto.ca/index.php/cpoj/article/view/35959/28326

How To Cite: Miller T.A, Wurdeman S, Paul R, Forthofer M. The value of health economics and outcomes research in prosthetics and orthotics. Canadian Prosthetics & Orthotics Journal. 2021; Volume 4, Issue 2, No.8. https://doi.org/10.33137/cpoj.v4i2.35959

Corresponding Author: Taavy A Miller, PhD, CPODepartment of Clinical and Scientific Affairs, Hanger Clinic, Austin, Texas, USA.E-Mail: tamiller@hanger.comORCID ID: https://orcid.org/0000-0001-7117-6124
THE DIGITAL O&P WORKSHOP
Authors: Opitz Manuel , Fröhlingsdorf Peter
Published: September 2021

Digitalisation is the megatrend in healthcare, not only since the pandemic. We are two European digital health experts and industry leaders in the field of orthotics and prosthetics (O&P) and in this article we explored what are the underlying trends driving the adoption of digitalisation for customisation of prosthetics & orthotics. We showed that several trends in 3D image capture (input step), 3D modelling (processing step) and 3D printing (output step) currently converge and thus fuel the rapid transformation of the O&P industry. In short outlooks, we rated the probability and timing of adoption rates across the upcoming couple of years. We furthermore reviewed the impact of boundary conditions set by regulators as well as the reimbursement system. Towards the end of this article, we outlined a digital scenario of the near future by following around an orthotist during her work. We finished with a call-to-action targeting regulators, payors, prosthetists/orthotists, and patients to enable such a desirable future.

Article PDF Link: https://jps.library.utoronto.ca/index.php/cpoj/article/view/36349/28332

How To Cite: Opitz M, Fröhlingsdorf P. The digital O&P workshop. Canadian Prosthetics & Orthotics Journal. 2021; Volume 4, Issue 2, No.15. https://doi.org/10.33137/cpoj.v4i2.36349

Corresponding Author: Manuel Opitz, MECURIS GmbH, Lindwurmstraße 11, 80337 München, Germany.E-Mail: mo@mecuris.comORCID number: https://orcid.org/0000-0001-6098-1881
Some Spiny Backed Orb-Weaving Spiders (Araneae: Araneidae) From Bangladesh
Authors: Biswas - , Raychaudhuri V , Raychaudhuri D
Published: September 2021

Spiny backed orb-weaving spiders sampled from different areas of Khulna and Bagerhat, Bangladesh were dealt with. Three species of the genus Gasteracantha Sundevall were recorded that includes one new species G. chowdhuryi n. sp. Generic diagnosis, illustrated description and distribution together with key to the species were provided herewith.
J. Biodivers. Conserv. Bioresour. Manag. 2020, 6(2): 35-46
Foraging Behaviour of Some Papilionid Butterflies in Bhawal and Madhupur Sal Forests of Bangladesh
Authors: Chowdhury MAK
Published: September 2021

Foraging behaviour of nine papilionid butterflies have been studied from two moist deciduous sal forests viz. Bhawal and Madhupur from central part of Bangladesh. Papilionid butterflies were found to visit 156 flowering plant species belong to 39 plant families. Dependency of papilionid butterflies on flowering plants varied from family to family with high dependency on family Asteraceae (15%) followed by Rubiaceae (8%), Rutaceae (6%), Verbenaceae (6%), Apocynaceae (6%) and Fabaceae (6%). Although most of the plant species (72 species, 47.68%) were visited by single butterfly species but some were also visited by multiple species of butterflies (e.g., Chromolaena odorata by 9 species, followed by Mikania cordata and Lantana camara by 8 and 7 species, respectively). Ninety eight percent (153 out of 156 species) of the nectar resources were dicotyledonous in origin but two percent plant species (three out of 156 species under three families) were monocotyledonous. Six floral attributes such as plants life forms, nature, perennation, origin, corolla shape and flower massing contributed butterflies significantly to visit plants for nectaring.
J. Biodivers. Conserv. Bioresour. Manag. 2020, 6(2): 55-68
Effects of Lead on Growth and Mineral Nutrition of Wheat (Triticum Aestivum L.) As Influenced by Manure and Lime
Authors: Jasmin P , Chamon AS , Mondol MN , Ullah SM
Published: September 2021

A pot experiment was conducted to evaluate the effects of four levels of lead (50, 100, 150 and 200 mg/kg) treatment on wheat (Triticum aestivum L.) and its amelioration by cowdung, poultry litter and lime. The lengths, fresh and dry weights of shoot and root decreased with increasing level of lead as well as the macronutrients compared to the control. The maximum reduction was observed in the pots treated with 200 mg/kg lead. The highest reduction in macronutrient content was also observed in 200 mg/kg Pb treated pot whereas N, P, K, Ca and Mg concentration was reduced by 0.41, 0.019, 1.15, 0.38 and 0.071% for shoot and 0.512, 0.071, 0.17, 0.51 and 0.122% for root, respectively. Lead concentration in roots and shoots increased with increasing level of lead treatment compared to the control. Cowdung was shown to be most effective, followed by poultry litter and lime. This particular organic manure had considerably greater decreasing impacts in lead uptake by wheat crops. Cowdung treated pots increased fresh and dry weight by 14.56 and 13.28% for grain, 7.58 and 7.08% for shoot and 2.41 and 2.06% for root compared to pot treated with 100 mg/kg lead.
J. Biodivers. Conserv. Bioresour. Manag. 2020, 6(2): 69-76
RACISMO E O DIREITO TRANSNACIONAL: A SIGNIFICAÇÃO DO SER NEGRO NO TEMPO E NOS ESPAÇOS PELOS QUAIS SE DESLOCA
Authors: De Jesus Daíra Andréa , Piffer Carla
Published: September 2021

O presente estudo trata do panorama transnacional do racismo, cuja publicização das ofensas é impulsionada pela globalização, restando escancaradas as dificuldades sofridas pelo “ser negro”, as quais se perpetuam no tempo e nos espaços pelos quais se desloca. Estruturado no método indutivo com a adoção da técnica do conceito operacional e da pesquisa bibliográfica, seu objetivo geral é categorizar o Direito Transnacional como rico instrumento de política antirracista, na medida em que visa a proteção do homem. Como objetivos específicos, se busca evidenciar o que é racismo e os fatos históricos e migratórios que lhe sustentam; apresentar o contexto transnacional da discriminação racial; e denunciar a ineficiência estatal, por meio dos tradicionais sistemas normativos internos, no combate ao racismo. Ao final, observar-se-á, que a discriminação racial desferida em face dos migrantes e nacionais, conforme meras características físicas, pode e merece ser enfrentada com os sólidos arcabouços afetos ao Direito Transnacional.
Palavras-Chave: Direito Transnacional. Globalização. Migrações. Racismo. Ser negro.
Abstract: The current study is about the transnational racism panorama, which the offense publicity is driven by globalization, remaining wide open difficulties suffered about “being black”, which perpetuated in time and spaces through it moves. Structured in the inductive method with the adoption of operational concept technique in the bibliographic, what general goals are to categorize Transnational Law as rich anti-racist political instrument, in a measure that considers protection of men. As specifics goals, its search the evidence in what is racism and the historical facts that sustains; to present the transnational context of racial discrimination; the States inefficiency, through their traditional normative systems in combating racism. By the end, it will be observed that racial discriminations in migrants and nationals, according to few physical characterizes, can and deserves to be seen structures of solid affect frameworks of Transnational Law.
Keywords: Transnational Law. Globalization. Migrations. Racism. Being black.
Real-world data: how they can help to improve quality of care
Authors: Corrao Giovanni , Alquati Giovanni , Apolone Giovanni , Ardizzoni Andrea , Buzzetti Giuliano , Canonica Giorgio W. , Conte Pierfranco , Crovato Elisa , Damele Francesco , La Vecchia Carlo , Maggioni Aldo P. , Mantovani Alberto , Marangi Michele , Marrocco Walter , Messori Andrea , Padovani Alessandro , Rambaldi Alessandro , Ricciardi Walter , Ripa di Meana Francesco , Spandonaro Federico , Tozzi Valeria , Mancia Giuseppe
Published: September 2021

The current COVID pandemic crisis made it even clearer that the solutions to several questions that public health must face require the access to good quality data. Several issues of the value and potential of health data and the current critical issues that hinder access are discussed in this paper. In particular, the paper (i) focuses on “real-world data” definition; (ii) proposes a review of the real-world data availability in our country; (iii) discusses its potential, with particular focus on the possibility of improving knowledge on the quality of care provided by the health system; (iv) emphasizes that the availability of data alone is not sufficient to increase our knowledge, underlining the need that innovative analysis methods (e.g., artificial intelligence techniques) must be framed in the paradigm of clinical research; and (v) addresses some ethical issues related to their use. The proposal is to realize an alliance between organizations interested in promoting research aimed at collecting scientifically solid evidence to support the clinical governance of public health.
Insights into the soil microbiome and prospects for its manipulation for improved pasture resilience
Authors: Shi Shengjing , Marshall Sean , Schon Nicole , Dignam Bryony , Bell Nigel , O'Callaghan Maureen
Published: September 2021

• The soil microbiome refers to the diverse collection of microorganisms present in soil, many of which can mediate essential soil functions such as nutrient cycling and plant pest and disease suppression.
• There is growing international interest in the potential to manipulate the soil microbiome to deliver improved agricultural and environmental outcomes.
• Molecular techniques are rapidly increasing understanding of the soil microbiome structure and function but manipulating soil microbiomes for pasture resilience still presents significant science challenges.
The Grotte du Renne, Leroi-Gourhan and Flaubert's La Légende de Saint Julien l'Hospitalier (1877): The Question of ‘Préhistoire(s)’ to Delimit the Human
Authors: Orr Mary
Published: September 2021

This article reconsiders the important work of Leroi-Gourhan through the lens of Christopher Johnson's ‘Leroi-Gourhan and the Limits of the Human’ (2011) by returning to the context of French prehistory of the 1860s that lies behind Leroi-Gourhan's discoveries and interpretations of hominid remains and artefacts in the Grotte du Renne. The Exposition universelle of 1867 and French publications of the period capture the importance of ‘préhistoire’ for Second Empire France materialized in Napoleon III's establishment at Saint-Germain-en-Laye of the first national Musée des Antiquités Nationales dedicated to their collections. The archaeological discoveries, and the debates they inspired, did not escape the encyclopaedic bricolage and designs of Flaubert. With delicious clins d'oeil to the question of ‘l'homme fossile’ and ‘l'homme futur’ that he had already debated with Louis Bouilhet, this article uncovers how Flaubert's Légende de Saint Julien details the ‘limits of the human’ in Johnson's reading of Leroi-Gourhan. By returning to ‘real’ counterparts for the legendary Stag in Flaubert's tale, its contextual, allegedly fantastical, ‘préhistoires’ can better be excavated. To find the non-legendary, extreme contemporary, sources for Flaubert's disturbing text crucially informs a critique of the dehistoricization of seeing in post-war French cultural studies and sciences of the human.
High Prevalence of Lactobacillus crispatus Dominated Vaginal Microbiome Among Kenyan Secondary School Girls: Negative Effects of Poor Quality Menstrual Hygiene Management and Sexual Activity
Authors: Mehta Supriya D. , Zulaika Garazi , Otieno Fredrick O. , Nyothach Elizabeth , Agingu Walter , Bhaumik Runa , Green Stefan J. , van Eijk Anna Maria , Kwaro Daniel , Phillips-Howard Penelope A.
Published: September 2021

The vaginal microbiome (VMB) impacts numerous health outcomes, but evaluation among adolescents is limited. We characterized the VMB via 16S rRNA gene amplicon sequencing, and its association with Bacterial vaginosis (BV) and sexually transmitted infections (STIs; chlamydia, gonorrhea, trichomoniasis) among 436 schoolgirls in Kenya, median age 16.9 years. BV and STI prevalence was 11.2% and 9.9%, respectively, with 17.6% of girls having any reproductive tract infection. Three community state types (CST) accounted for 95% of observations: CST-I L.crispatus-dominant (N=178, BV 0%, STI 2.8%, sexually active 21%); CST-III L.iners-dominant (N=152, BV 3.3%, STI 9.7%, sexually active 35%); CST-IV G.vaginalis-dominant (N=83, BV 51.8%, STI 25.3%, sexually active 43%). In multivariable adjusted analyses, sexually active girls had increased odds of CST-III and CST-IV, and use of cloth to manage menses had 1.72-fold increased odds of CST-IV vs. CST-I. The predominance of L.crispatus-dominated VMB, substantially higher than observed in prior studies of young adult and adult women in sub-Saharan Africa, indicates that non-optimal VMB can be an acquired state. Interventions to maintain or re-constitute L.crispatus dominance should be considered even in adolescents.
Molecular Characterization of Rotifers and Their Potential Use in the Biological Control of Biomphalaria
Authors: Lin Datao , Xiang Suoyu , Sanogo Benjamin , Liang Yousheng , Sun Xi , Wu Zhongdao
Published: September 2021

Background

Schistosomiasis is one of the most important tropical parasitic diseases worldwide. Biomphalaria straminea, the intermediate host of Schistosoma mansoni, has invaded and spread to Southern China since 1974 and may pose enormous threats to public health. Controlling intermediate host snails is an effective strategy in schistosomiasis intervention. However, the only effective chemical molluscicide, niclosamide, currently recommended by WHO may cause environmental pollution, loss of biodiversity, and high costs. Thus, to counter intermediate hosts, a sustainable and environmentally friendly tool is urgently needed. Here, we conducted field investigations to collect and identify a potential snail competitor rotifer and evaluated its molluscicide effect.

Results

In this study, we collected two samples of rotifers from Shenzhen. We found both red and black phenotypic B. straminea snails at the sampling sites. We identified the rotifer population as a species of the genus Philodina according to the amplification and phylogenetic analysis results of coxI gene. We found that rotifer exposure did not significantly affect the hatching rate of B. straminea eggs but promoted the killing of juvenile snails. Meanwhile, rotifer exposure did not significantly alter the fecundity of B. straminea quantified by the number of eggs per egg mass, the number of egg masses per snail, and the number of eggs per snail; but the snails exposed to rotifers showed lower fecundity performance than the control snails. Importantly, rotifer exposure could significantly affect the development of juvenile B. straminea, showing a smaller shell diameter of the exposed snails than that of the control snails. In addition, rotifer exposure affected the life span of B. straminea snails, showing a 16.61% decline in the average life span. After rotifer exposure, the S. mansoni-infected B. straminea snails died significantly faster than those without rotifer exposure. Similar findings were observed in S. mansoni-infected Biomphalaria glabrata snails. These results implied that rotifer exposure significantly promoted the mortality of S. mansoni-infected B. straminea and B. glabrata.

Conclusions

Our study demonstrated the potential molluscicide effect of rotifers on intermediate hosts under laboratory conditions. Our findings may provide new insights into the development of biocontrol strategies for snail-borne disease transmission.
The Relationship and Gender Disparity Between Thyroid Nodules and Metabolic Syndrome Components Based on a Recent Nationwide Cross-Sectional Study and Meta-Analysis
Authors: Zhang Fan , Li Yongze , Yu Xiaohui , Wang Xichang , Lin Zheyu , Song Bo , Tian Lijun , Feng Chuyao , Shan Zhongyan , Teng Weiping
Published: September 2021

Background

Metabolic syndrome (MetS) has a potential connection with thyroid disease, but its relationship with thyroid nodules (TNs) is still controversial. This study aims to clarify the relationship between MetS and TNs, and this relationship in the subgroup of gender.

Methods

The recent nationwide cross-sectional study called Thyroid Disorders, Iodine Status, and Diabetes Epidemiological survey provided the newest data on the relationship between MetS and TNs from China and included 56,729 subjects. We also researched related literature in PubMed, EMBASE, Cochrane Library, and MEDLINE until Oct 30, 2020, in order to perform a meta-analysis. The relevant articles were examined, and the eligible studies were included to assess the association between MetS and TNs.

Results

The meta-analysis included 15 studies (involving 468,845 subjects). Of these, 14 studies were from the databases, and one study was this cross-sectional data. The meta-analysis showed that TNs were associated with a higher prevalence of MetS (OR=1.87, 95% CI: 1.44–2.45) and the components of MetS, including central obesity (OR=1.41, 95% CI: 1.15–1.72), hypertriglyceridemia (OR=1.13, 95% CI: 1.10–1.15), low high-density lipoprotein cholesterolemia (OR=1.11, 95% CI: 1.02–1.20), abnormal blood pressure (OR=1.68, 95% CI: 1.62–1.75), and hyperglycemia (OR=1.59, 95% CI: 1.46–1.74). Central obesity displayed gender differences, being a risk factor in males (OR=1.38, 95% CI: 1.02–1.86) but not in females (OR=1.47, 95% CI: 0.97–2.23).

Conclusion

TNs were indeed associated with a higher prevalence of MetS. In addition, its component diseases, such as central obesity, hypertriglyceridemia, abnormal blood pressure, and hyperglycemia, were also associated with TNs. Females with MetS or its components had a higher risk of suffering from TNs than males.
Neurodevelopmental Disorders in Patients With Complex Phenotypes and Potential Complex Genetic Basis Involving Non-Coding Genes, and Double CNVs
Authors: Servetti Martina , Pisciotta Livia , Tassano Elisa , Cerminara Maria , Nobili Lino , Boeri Silvia , Rosti Giulia , Lerone Margherita , Divizia Maria Teresa , Ronchetto Patrizia , Puliti Aldamaria
Published: September 2021

Neurodevelopmental disorders (NDDs) are a heterogeneous class of brain diseases, with a complex genetic basis estimated to account for up to 50% of cases. Nevertheless, genetic diagnostic yield is about 20%. Array-comparative genomic hybridization (array-CGH) is an established first-level diagnostic test able to detect pathogenic copy number variants (CNVs), however, most identified variants remain of uncertain significance (VUS). Failure of interpretation of VUSs may depend on various factors, including complexity of clinical phenotypes and inconsistency of genotype-phenotype correlations. Indeed, although most NDD-associated CNVs are de novo, transmission from unaffected parents to affected children of CNVs with high risk for NDDs has been observed. Moreover, variability of genetic components overlapped by CNVs, such as long non-coding genes, genomic regions with long-range effects, and additive effects of multiple CNVs can make CNV interpretation challenging. We report on 12 patients with complex phenotypes possibly explained by complex genetic mechanisms, including involvement of antisense genes and boundaries of topologically associating domains. Eight among the 12 patients carried two CNVs, either de novo or inherited, respectively, by each of their healthy parents, that could additively contribute to the patients’ phenotype. CNVs overlapped either known NDD-associated or novel candidate genes (PTPRD, BUD13, GLRA3, MIR4465, ABHD4, and WSCD2). Bioinformatic enrichment analyses showed that genes overlapped by the co-occurring CNVs have synergistic roles in biological processes fundamental in neurodevelopment. Double CNVs could concur in producing deleterious effects, according to a two-hit model, thus explaining the patients’ phenotypes and the incomplete penetrance, and variable expressivity, associated with the single variants. Overall, our findings could contribute to the knowledge on clinical and genetic diagnosis of complex forms of NDD.
CircDTL Functions as an Oncogene and Regulates Both Apoptosis and Ferroptosis in Non-small Cell Lung Cancer Cells
Authors: Shanshan Wang , Hongying Ma , Jingjing Fang , Yiming Yu , Yu Ren , Rui Yu
Published: September 2021

Background: Circular RNAs (circRNA) play an essential role in the tumorigenesis of non-small cell lung cancer (NSCLC). CircDTL is a novel identified circRNA with little information regarding its biological role. However, the role of circDTL in NSCLC has not been investigated yet.

Method: In this study, the levels of circDTL in tissues and cells were measured by RT-PCR. Cell viability was measured by the CCK-8 assay. Cell migration and invasion were evaluated using the wound healing assay and transwell assay, respectively. Cell death was measured by the cell death ELISA kit. The levels of Fe2+, ROS, MDA and GSH were measured using the commercial kits. The interactions between miR-1287-5p and circDTL/3′UTR GPX4 were verified by dual-luciferase activity assay. The effects of circDTL on tumor growth were evaluated in vivo.

Results: CircDTL was found to be upregulated and acted as an oncogene in NSCLC cells. Knockdown of circDTL promoted both apoptosis and ferroptosis of NSCLC cells. It was identified that circDTL exerts its oncogenic effects via the circDTL/miR-1287-5p/GPX4 axis and GPX4 inhibits both ferroptosis and apoptosis. Finally, this study showed that silencing of circDTL promoted the sensitivity of NSCLC cells to chemotherapeutic agents and inhibited the growth of tumors in vivo.

Conclusion: CircDTL acts as an oncogene and exerts its effects via the miR-1287-5p/GPX4 axis in NSCLC, providing a potential therapeutic target for NSCLC cancer therapy.
Macrophages Control the Bioavailability of Vitamin D and Vitamin D-Regulated T Cell Responses
Authors: Lopez Daniel Villalba , Al-Jaberi Fatima A. H. , Woetmann Anders , Ødum Niels , Bonefeld Charlotte Menné , Kongsbak-Wismann Martin , Geisler Carsten
Published: September 2021

The active form of vitamin D3 (1,25(OH)2D3) has a great impact on T cell effector function. Thus, 1,25(OH)2D3 promotes T helper 2 (Th2) and regulatory T (Treg) cell function and concomitantly inhibits Th1 and Th17 cell function. Thus, it is believed that vitamin D exerts anti-inflammatory effects. However, vitamin D binding protein (DBP) strongly binds both 1,25(OH)2D3 and the precursor 25(OH)D3, leaving only a minor fraction of vitamin D in the free, bioavailable form. Accordingly, DBP in physiological concentrations would be expected to block the effect of vitamin D on T cells and dendritic cells. In the present study, we show that pro-inflammatory, monocyte-derived M1 macrophages express very high levels of the 25(OH)D-1α-hydroxylase CYP27B1 that enables them to convert 25(OH)D3 into 1,25(OH)2D3 even in the presence of physiological concentrations of DBP. Co-cultivation of M1 macrophages with T cells allows them to overcome the sequestering of 25(OH)D3 by DBP and to produce sufficient levels of 1,25(OH)2D3 to affect T cell effector function. This study suggests that in highly inflammatory conditions, M1 macrophages can produce sufficient levels of 1,25(OH)2D3 to modify T cell responses and thereby reduce T cell-mediated inflammation via a vitamin D-mediated negative feed-back loop.
Poleward Propagation of Typhoon-Induced Near-Inertial Waves in the Northern South China Sea
Authors: Huang Ruhui , Xie Xiaohui , Hu Jianyu , Sun Zhenyu
Published: September 2021

One of the main responses of the ocean to typhoons is the generation of near-inertial waves (NIWs), whose intrinsic frequency is close to the local inertial frequency. Based on the mooring observations, we carefully investigated the spatial–temporal variations in NIWs in the northern South China Sea (SCS) after Typhoon “Haima,” which passed through the northern SCS from October 20 to 21, 2016, with its track parallel to the mooring array on its northeast side. Moorings in different locations responded differently to this typhoon, with stronger NIWs found on the continental slope to the shelf break and relatively weak NIWs found on the shallow continental shelf. Strong NIWs appeared twice within a short period and showed different characteristics and frequencies. The first NIWs were generated locally with blue-shifted (super-inertial) frequencies. These initial NIWs were dominated by the first three baroclinic modes and rapidly weakened due to their propagation away and local dissipation. However, the second NIWs mainly consisted of higher baroclinic modes with red-shifted (sub-inertial) frequencies. The analysis of the mean background flow revealed that these red-shifted NIWs were excited at low latitudes, and subsequently advected by the poleward background flow to moorings whose latitudes were higher than their critical latitudes. Higher-mode (n > 3) NIWs were more easily carried away by mean background flow, and, at the same time, high-mode NIWs propagated downward to the subsurface layer, leading to the significant elevation of velocity shear therein. Given these findings, the mean background flow may provide an important route to redistributing the energy of the upper ocean imported from typhoons.
Astrocytic and Neuronal Apolipoprotein E Isoforms Differentially Affect Neuronal Excitability
Authors: Konings Sabine C. , Torres-Garcia Laura , Martinsson Isak , Gouras Gunnar K.
Published: September 2021

Synaptic changes and neuronal network dysfunction are among the earliest changes in Alzheimer’s disease (AD). Apolipoprotein E4 (ApoE4), the major genetic risk factor in AD, has been shown to be present at synapses and to induce hyperexcitability in mouse knock-in brain regions vulnerable to AD. ApoE in the brain is mainly generated by astrocytes, however, neurons can also produce ApoE under stress conditions such as aging. The potential synaptic function(s) of ApoE and whether the cellular source of ApoE might affect neuronal excitability remain poorly understood. Therefore, the aim of this study was to elucidate the synaptic localization and effects on neuronal activity of the two main human ApoE isoforms from different cellular sources in control and AD-like in vitro cultured neuron models. In this study ApoE is seen to localize at or near to synaptic terminals. Additionally, we detected a cellular source-specific effect of ApoE isoforms on neuronal activity measured by live cell Ca2+ imaging. Neuronal activity increases after acute but not long-term administration of ApoE4 astrocyte medium. In contrast, ApoE expressed by neurons appears to induce the highest neuronal firing rate in the presence of ApoE3, rather than ApoE4. Moreover, increased neuronal activity in APP/PS1 AD transgenic compared to wild-type neurons is seen in the absence of astrocytic ApoE and the presence of astrocytic ApoE4, but not ApoE3. In summary, ApoE can target synapses and differentially induce changes in neuronal activity depending on whether ApoE is produced by astrocytes or neurons. Astrocytic ApoE induces the strongest neuronal firing with ApoE4, while the most active and efficient neuronal activity induced by neuronal ApoE is caused by ApoE3. ApoE isoforms also differentially affect neuronal activity in AD transgenic compared to wild-type neurons.
Curcumin Extraction, Isolation, Quantification and Its Application in Functional Foods: A Review With a Focus on Immune Enhancement Activities and COVID-19
Authors: Tripathy Soubhagya , Verma Deepak Kumar , Thakur Mamta , Patel Ami R. , Srivastav Prem Prakash , Singh Smita , Gupta Alok Kumar , Chávez-González Mónica L. , Aguilar Cristobal Noe , Chakravorty Nishant , Verma Henu Kumar , Utama Gemilang Lara
Published: September 2021

An entirely unknown species of coronavirus (COVID-19) outbreak occurred in December 2019. COVID-19 has already affected more than 180 million people causing ~3.91 million deaths globally till the end of June 2021. During this emergency, the food nutraceuticals can be a potential therapeutic candidate. Curcumin is the natural and safe bioactive compound of the turmeric (Curcuma longaL.) plant and is known to possess potent anti-microbial and immuno-modulatory properties. This review paper covers the various extraction and quantification techniques of curcumin and its usage to produce functional food. The potential of curcumin in boosting the immune system has also been explored. The review will help develop insight and new knowledge about curcumin's role as an immune-booster and therapeutic agent against COVID-19. The manuscript will also encourage and assist the scientists and researchers who have an association with drug development, pharmacology, functional foods, and nutraceuticals to develop curcumin-based formulations.
Diffuse Josephson Radiation in Turbulence
Authors: Treumann R. A. , Baumjohann Wolfgang
Published: September 2021

The possibility of generating diffuse radiation in extended astronomical media by plasma turbulence is investigated under the assumption that the turbulence can be understood as an ensemble of small-scale magnetic filaments (narrow current sheets) forming a texture around a large number of magnetic depletions or voids. On astronomically microscopic scales, the dilute high temperature medium (plasma) is to be considered ideally conducting, forming a collection of Josephson junctions between two such adjacent quasi-superconductors. The oscillation frequency of those junctions depends on the part of the spectrum that contributes to the oscillation, causing weak radio backgrounds. Lowest Josephson frequencies/energies near zero may become sources of quasi-stationary magnetic fields.
Spectral Evolution of an Eruptive Polar Crown Prominence With IRIS Observations
Authors: Xue Jianchao , Li Hui , Su Yang
Published: September 2021

Prominence eruption is closely related to coronal mass ejections and is an important topic in solar physics. Spectroscopic observation is an effective way to explore the plasma properties, but the spectral observations of eruptive prominences are rare. In this paper we will introduce an eruptive polar crown prominence with spectral observations from the Interface Region Imaging Spectrograph (IRIS), and try to explain some phenomena that are rarely reported in previous works. The eruptive prominence experiences a slow-rise and fast-rise phase, while the line-of-sight motions of the prominence plasma could be divided into three periods: 2 hours before the fast-rise phase, opposite Doppler shifts are found at the two sides of the prominence axis; then, red shifts dominate the prominence gradually; in the fast-rise phase, the prominence gets to be blue-shifted. During the second period, a faint component appears in Mg ii k window with a narrow line width and a large red shift. A faint region is also found in AIA 304Å images along the prominence spine, and the faint region gets darker during the expansion of the spine. We propose that the opposite Doppler shifts in the first period is a feature of the polar crown prominence that we studied. The red shifts in the second period are possibly due to mass drainage during the elevation of the prominence spine, which could accelerate the eruption in return. The blue shifts in the third period are due to that the prominence erupts toward the observer. We suggest that the faint component appears due to the decreasing of the plasma density, and the latter results from the expansion of the prominence spine.