bluuebunny/crossref_metadata_2025 huggingface dataset:
Wildfire Response Performance Measurement: Current and Future Directions
Authors: Thompson Matthew P. , Lauer Christopher J. , Calkin David E. , Rieck Jon D. , Stonesifer Crystal S. , Hand Michael S.
Published: June 2018

The Forest Service, U.S. Department of Agriculture, defines success in the wildland fire response environment as “safely achieving reasonable objectives with the least firefighter exposure necessary while enhancing stakeholder support for our management efforts”. However, persistent information and knowledge gaps challenge the agency’s ability to measure success in coming fire seasons. In this paper, we outline a roadmap to help fill these gaps, describing progress towards developing meaningful fire response key performance indicators (KPIs). We focus on characterizing suppression resource use and effectiveness as requisite initial steps towards reducing unnecessary exposure. Our intentions are to articulate the rationale for embracing KPIs for fire response operations, briefly review best practices as they relate to organizational performance measurement, and describe recent and emerging analysis techniques designed to ultimately improve responder exposure assessment. Specifically, we review tangible research products that could be operationalized as KPIs in the near future, and illustrate their calculation and interpretation for a set of large fires that occurred in the U.S. in 2017. To conclude, we offer thoughts on productive pathways forward with performance measurement.
Biochemical, Microbiological, and Sensory Properties of Dried Silver Carp (Hypophthalmichthys molitrix) Influenced by Various Drying Methods
Authors: Rasul Md. Golam , Majumdar Bhaskar Chandra , Afrin Faria , Bapary Mohammad Abu Jafor , Shah A.K.M. Azad
Published: June 2018

An experiment was performed to evaluate the effects of different drying methods with different pre-treatments on the physico-chemical, microbiological, and sensory properties of the silver carp, Hypophthalmichthys molitrix. In order to achieve this objective, the collected fresh fish were dried using traditional (without any pre-treatment), improved (fish soaked in a 5% salt solution for 10 min and then treated with chili powder (0.3%) and turmeric powder (0.3%)), and solar tunnel (fish soaked in a 5% salt solution for 10 min) drying methods. The results showed that the dried fish produced by the solar tunnel drying method were rehydrated more rapidly than the products produced by the traditional and improved drying methods. The moisture content of the dried H. molitrix was varied from 18.24 to 25.43% on a fresh matter basis. There was no significant (p > 0.05) difference found regarding the protein, lipid, and ash content among the different drying methods on a dry matter basis. The total volatile base nitrogen (TVB-N) contents ranged between 37.58 and 45.03 mg/100 g, and significantly (p < 0.05) the lowest TVB-N was observed in dried fish produced by the solar tunnel drying method. Moreover, the highest peroxide and acid values were found in the traditionally produced dried fish as compared with the fish dried by the improved and solar tunnel drying methods. The aerobic plate count of dried fish ranged from 4.52 to 7.51 log CFU/g. The sensory evaluation results revealed that the solar-dried products showed superior quality than the products produced by the traditional and improved drying methods. The results revealed that the dried fish produced by the solar tunnel drying method provided the best product in terms of physico-chemical, microbiological, and sensory aspects.
Associations between Religiosity, Spirituality, and Happiness among Adults Living with Neurological Illness
Authors: Wade James B. , Hayes Rashelle B. , Wade James H. , Bekenstein Jonathan W. , Williams Kristin D. , Bajaj Jasmohan S.
Published: June 2018

The study examined the associations between religiosity, spirituality, and happiness in 354 outpatients suffering from neurological disorders. After accounting for severity of cognitive decline, physical activity level, depression severity, and demographic variables (i.e., subject age, sex, ethnicity, and marital status) multivariate linear regression revealed a unique association between the Spiritual Well-Being Existential Spirituality scale (SWBS ES), and not the SWBS Religious Scale (SWBS RS), with both the Pemberton Remembered Happiness Index (PHI R) (p < 0.001), and the Pemberton Experienced Happiness Index (PHI E) (p < 0.001). Interventions focused on existential spirituality may improve health related quality of life among adult medical patients with neurological illness.
Improving Cardiovascular Disease Knowledge among Rural Participants: The Results of a Cluster Randomized Trial
Authors: Abbott Laurie S. , Slate Elizabeth H.
Published: June 2018

Cardiovascular disease (CVD) is a major cause of death and disability, especially among people living in the rural, southern United States. Rural African Americans are often diagnosed with CVD earlier in life, and they bear a disproportionate burden of CVD risk factors, morbidity, and mortality. Health equity among historically underserved, rural populations can potentially be attained through culturally relevant interventions that teach people skills to stay well and avoid CVD-related risk and diagnoses. The purpose of this secondary analysis was to determine the effect of an evidence-based intervention on cardiovascular health knowledge and the stages of change toward the action and maintenance phases. The pre-test-post-test data were obtained during a cluster randomized trial involving twelve rural churches that were randomized to intervention (n = 6) and control (n = 6) groups. Participants (n = 115) in the intervention group received a cardiovascular health intervention, and those (n = 114) in the control group could receive the intervention following the study’s completion. The data were analyzed using a linear mixed model to compare group differences from pre-test to post-test. The cardiovascular health promotion intervention significantly improved cardiovascular health knowledge and was associated with advancements in the stages of change toward the action and maintenance phases.
Weather and Suicide: A Decade Analysis in the Five Largest Capital Cities of Colombia
Authors: Fernández-Niño Julián , Flórez-García Víctor , Astudillo-García Claudia , Rodríguez-Villamizar Laura
Published: June 2018

Historically, seasonal variations in suicide rates were thought to be associated with changes in weather. Most of this evidence however, is based on studies that were conducted in developed countries that are located outside the tropics. As such, it is necessary to examine this association in developing countries, such as Colombia, which do not experience marked seasons. In addition, it is important to adjust for the effect of holidays when analyzing this association as they have been reported to be a relevant confounding factor. Our objective was to estimate the association between daily suicide incidence among men and women in five major Colombian cities (Bogotá, Medellin, Cali, Barranquilla, and Bucaramanga) and daily temperature and rainfall. For this purpose, we conducted a multi-city, multi-temporal ecological study from 2005 to 2015, using data from the suicide mortality registries (provided by the National Administrative Department of Statistics). Daily measurements of the two weather variables were obtained from the official historical registry of the meteorological station at each city airport. We used these data to estimate conditional Poisson models for daily suicide counts, stratifying by sex and adjusting for holidays. Although we found that none of the weather variable estimators could reject the null hypothesis, we uncovered an association between suicide incidence and long weekends in the total suicide model (Incidence Rate Ratio (IRR): 1.19, 95% confidence interval (CI): 1.04–1.23). We found no evidence of association between weather variables and suicide in Colombia. Our study is based on daily observations and it provides evidence of absence of this association in a tropical country that does not experience marked seasons.
Impact of the Familiar Environment in 11–14-Year-Old Minors’ Mental Health
Authors: León-del-Barco Benito , Fajardo-Bullón Fernando , Mendo-Lázaro Santiago , Rasskin-Gutman Irina , Iglesias-Gallego Damián
Published: June 2018

The analysis of the mental health in children under 14 years has become a research topic of global interest where the family can be a key factor for protection or risk against mental health problems. With this work, we intend to determine, employing binary logistic regression analysis, whether parental acceptance-rejection perceived by boys and girls can predict their mental health. Seven hundred sixty-two students participated, the average age was 12.23 years; 53.8% (n = 410) girls and 46.2% (n = 352) boys. We have used the Strengths and Difficulties Questionnaire (SDQ), self-reported version and the Affection Scale children version (EA-H) for parental acceptance-rejection to assess mental health. The odds ratio (OR) of the logistic models reports that there is a greater probability of having mental health problems in boys and girls when they perceive that they are highly criticized and rejected by their parents. With our work, we highlight the importance of the environment and family affection on mental health. The perception of the children about the rejection, aversion, and criticism of their parents constitutes a risk factor in the manifestation of mental health problems.
A Review of Methods for Assessing the Environmental Health Impacts of an Agricultural System
Authors: Grout Leah , Hales Simon , French Nigel , Baker Michael G.
Published: June 2018

(1) Background: Global agricultural production is projected to increase substantially in the coming decades. Agricultural production provides food and materials crucial to human survival and well-being and is a critical source of livelihood, providing employment opportunities and economic benefits. However, industrialized or intensified agricultural systems, in particular, can have adverse effects on public health, place pressure on natural resources, and reduce environmental sustainability. This review attempts to identify and characterize key environmental health assessment methods for examining a broad array of potential impacts; (2) Methods: Electronic databases Medline, Scopus, Web of Science, and GreenLINE were searched for published literature that presented methods for conducting an environmental health assessment of an agricultural system; (3) Results: Fifty-three sources were included in the review. Eight methods were selected to illustrate the wide range of approaches currently available: health risk assessment methods, health impact assessment, environmental impact assessment methods, environmental burden of disease, lifecycle methods, integrated assessment modeling, trade-off analysis, and economic assessment; (4) Conclusions: This review can provide guidance for selecting an existing method or for designing a new method for assessing the environmental health impacts of an agricultural system.
A Dual-Channel Supply Chain Coordination under Carbon Cap-and-Trade Regulation
Authors: Qi Qi , Wang Jing , Xu Jianteng
Published: June 2018

We consider a dual-channel supply chain coordination under a carbon cap-and-trade regulation. The dual-channel refers to the traditional retail channel and the network direct channel, and both two channels’ selling prices can affect the market demand. We formulate the problem as a supplier-Stackelberg game model and obtain the optimal pricing decisions and corresponding profits in centralized and decentralized systems. We explore the effects of cap-and-trade regulation on optimal decisions and profits. To improve the performance of the decentralized system, we propose online channel price discount and offline channel price discount contracts to coordinate dual-channel supply chain and provide a transfer payment mechanism to make win-win of both sides. Moreover, we investigate how carbon regulation affects the coordination performance. Numerical examples illustrate the process to find the appropriate price discount coefficient and show the coordination effects of two contracts.
Mental Health Literacy in Young Adults: Adaptation and Psychometric Properties of the Mental Health Literacy Questionnaire
Authors: Dias Pedro , Campos Luísa , Almeida Helena , Palha Filipa
Published: June 2018

Mental health literacy (MHL) is considered a prerequisite for early recognition and intervention in mental disorders, and for this reason, it has become a focus of research over the past few decades. Assessing this construct is relevant for identifying knowledge gaps and erroneous beliefs concerning mental health issues, to inform the development of interventions aimed at promoting mental health literacy as well as the evaluation of these interventions. Recently, we developed a new self-reporting measure (MHLq) for assessing mental health literacy in young people (12–14 years-old), meeting the need to assess MHL from a comprehensive perspective of the construct instead of focusing on a restricted number of mental disorders or specific dimensions (e.g., knowledge concerning specific disorders; stigma). The present study aimed to adapt the MHLq for the young adult population and to examine its psychometric properties, according to the following steps: (1) item adaptation, using a think aloud procedure (n = 5); (2) data collection (n = 356, aged between 18 and 25 years old; and (3) psychometric analyses (exploratory factor analysis and internal consistency analysis). The final version of the questionnaire included 29 items (total scale α = 0.84), organized by four dimensions: (1) knowledge of mental health problems (α = 0.74); (2) erroneous beliefs/stereotypes (α = 0.72); (3) help-seeking and first aid skills (α = 0.71); and (4) self-help strategies (α = 0.60). The results suggest that the MHLq-adult form is a practical, valid, and reliable screening tool for identifying gaps in knowledge, beliefs, and behavioral intentions related to mental health and mental disorders, planning promotion programs, and evaluating intervention effectiveness.
Rural Households’ Livelihood Capital, Risk Perception, and Willingness to Purchase Earthquake Disaster Insurance: Evidence from Southwestern China
Authors: Xu Dingde , Liu Enlai , Wang Xuxi , Tang Hong , Liu Shaoquan
Published: June 2018

Earthquake disaster insurance can effectively reduce the impact of earthquake disasters on rural households. Exploring rural households’ willingness to purchase earthquake disaster insurance in earthquake disaster areas provides an understanding of the motivations underlying the implementation of an insurance policy. However, few studies have examined the perspectives of rural households, in order to explore the correlations between the rural households’ livelihood capital, their disaster risk perception, and their willingness to purchase earthquake disaster insurance. A cross-sectional survey data including 241 rural households from the most severe disaster counties (cities) during the 5 • 12 Wenchuan earthquake was examined with regard to rural households’ livelihood and disaster risk perception, and ordinal logistic regression models were constructed to explore rural households’ willingness to purchase earthquake disaster insurance, as well as the driving mechanism behind this willingness. The results showed that 34.44% of rural households were very willing to purchase earthquake disaster insurance, and 7.05% of rural households were very reluctant to purchase earthquake insurance. Rural households’ livelihood capital and risk perceptions were the most important factors affecting their willingness to purchase earthquake disaster insurance. Rural households with higher scores on natural capital, physical capital, possibility, and worry were more likely to purchase earthquake disaster insurance. Specifically, keeping all other variables constant, every one unit increase in nature capital and physical capital corresponded to an increase in the odds of willingness to purchase earthquake disaster insurance by a factor of 0.14 and 0.06, respectively; every one unit increase in possibility and worry corresponded to an increase in the odds of willingness to purchase earthquake disaster insurance by a factor of 0.03 and 0.04, respectively. This study contributes to the current literature by increasing the understanding of the relationships between Chinese rural households’ livelihood capital and risk perceptions, and their willingness to purchase earthquake disaster insurance.
Risk Factors for Ventricular Septal Defects in Murmansk County, Russia: A Registry-Based Study
Authors: Kovalenko Anton A. , Anda Erik Eik , Odland Jon Øyvind , Nieboer Evert , Brenn Tormod , Krettek Alexandra
Published: June 2018

Cardiovascular malformations are one of the most common birth defects among newborns and constitute a leading cause of perinatal and infant mortality. Although some risk factors are recognized, the causes of cardiovascular malformations (CVMs) remain largely unknown. In this study, we aim to identify risk factors for ventricular septal defects (VSDs) in Northwest Russia. The study population included singleton births registered in the Murmansk County Birth Registry (MCBR) between 1 January 2006 and 31 December 2011. Infants with a diagnosis of VSD in the MCBR and/or in the Murmansk Regional Congenital Defects Registry (up to two years post-delivery) constituted the study sample. Among the 52,253 infants born during the study period there were 744 cases of septal heart defects (SHDs), which corresponds to a prevalence of 14.2 [95% confidence interval (CI) of 13.2–15.3] per 1000 infants. Logistic regression analyses were carried out to identify VSD risk factors. Increased risk of VSDs was observed among infants born to mothers who abused alcohol [OR = 4.83; 95% CI 1.88–12.41], or smoked during pregnancy [OR = 1.35; 95% CI 1.02–1.80]. Maternal diabetes mellitus was also a significant risk factor [OR = 8.72; 95% CI 3.16–24.07], while maternal age, body mass index, folic acid and multivitamin intake were not associated with increased risk. Overall risks of VSDs for male babies were lower [OR = 0.67; 95% CI 0.52–0.88].
Improved Prediction of Harmful Algal Blooms in Four Major South Korea’s Rivers Using Deep Learning Models
Authors: Lee Sangmok , Lee Donghyun
Published: June 2018

Harmful algal blooms are an annual phenomenon that cause environmental damage, economic losses, and disease outbreaks. A fundamental solution to this problem is still lacking, thus, the best option for counteracting the effects of algal blooms is to improve advance warnings (predictions). However, existing physical prediction models have difficulties setting a clear coefficient indicating the relationship between each factor when predicting algal blooms, and many variable data sources are required for the analysis. These limitations are accompanied by high time and economic costs. Meanwhile, artificial intelligence and deep learning methods have become increasingly common in scientific research; attempts to apply the long short-term memory (LSTM) model to environmental research problems are increasing because the LSTM model exhibits good performance for time-series data prediction. However, few studies have applied deep learning models or LSTM to algal bloom prediction, especially in South Korea, where algal blooms occur annually. Therefore, we employed the LSTM model for algal bloom prediction in four major rivers of South Korea. We conducted short-term (one week) predictions by employing regression analysis and deep learning techniques on a newly constructed water quality and quantity dataset drawn from 16 dammed pools on the rivers. Three deep learning models (multilayer perceptron, MLP; recurrent neural network, RNN; and long short-term memory, LSTM) were used to predict chlorophyll-a, a recognized proxy for algal activity. The results were compared to those from OLS (ordinary least square) regression analysis and actual data based on the root mean square error (RSME). The LSTM model showed the highest prediction rate for harmful algal blooms and all deep learning models out-performed the OLS regression analysis. Our results reveal the potential for predicting algal blooms using LSTM and deep learning.
The Association between Molar-Incisor Hypomineralization and Dental Caries with Socioeconomic Status as an Explanatory Variable in a Group of Finnish Children
Authors: Wuollet Emma , Laisi Sakari , Alaluusua Satu , Waltimo-Sirén Janna
Published: June 2018

The aim of this study was to investigate if a developmental enamel defect known as Molar-Incisor Hypomineralization (MIH) is associated with dental caries. Socioeconomic status (SES) was examined as a confounding factor between caries and MIH. In this cross-sectional study, 636 children, aged 8 to 13 years, from three towns (two rural areas and one urban area) in Finland were examined for MIH in line with the criteria of the European Academy of Paediatric Dentistry. Caries status for permanent teeth was recorded as decayed, missing and filled teeth (DMFT). Caries experience (DMFT > 0) in the first permanent molars (FPMs) was set as an outcome. SES was determined using a questionnaire completed by parents. The prevalence of MIH was 18.1%. The mean DMFT in FPMs for children with MIH was higher than for their peers, 1.03 ± 1.25 vs. 0.32 ± 0.80 (p = 0.000, Mann-Whitney U test). In a multivariate analysis using the generalized linear mixed model where locality, SES, age and MIH were taken into account as caries risk indicators, MIH was the strongest risk indicator of caries in FPMs (Odds Ratio: 6.60, 95% Confidence Interval: 3.83–11.39, p = 0.000). According to the study results, children with MIH have a higher risk for dental caries than children without MIH.
Estimation of Mercury Emission from Incineration of Extracted Teeth with Dental Amalgam Fillings in South Korea
Authors: Kim Hae-Jin , Park Ji-Hye , Sakong Joon
Published: June 2018

This study is aimed to estimate the levels of mercury emission related to amalgam fillings at dental institutions in order to provide basic data for establishing a management protocol for extracted mercury-containing amalgam fillings. We conducted a cross-sectional study at a dental clinic of a general hospital (City of Daegu), a dental hospital (City of Daegu), and five private dental clinics (one in the South and four in the North Gyeongsang Province). The extracted anterior and posterior teeth (N = 1208) were separated, and the amalgam filling rate of the posterior teeth was assessed. After cutting out the amalgam from filled posterior teeth, the weight of the amalgam was measured, and the estimated mercury emission was calculated based on the equation, where annual number of extracted posterior teeth × amalgam filling rate (%) × mean amalgam weight (g) × 0.5 (the proportion of mercury in amalgam). We found that 48.86 kg (95% confidence interval [CI] 41.53–58.63 kg) of mercury had been incinerated along with the extracted teeth. After applying the dental institution weights, the estimated amount of mercury was 42.53 kg (95% CI 34.11–52.17 kg). The amount of mercury incinerated with extracted posterior teeth at Korean dental institutions is therefore about 42.53–48.86 kg/year.
Predicted Mercury Soil Concentrations from a Kriging Approach for Improved Human Health Risk Assessment
Authors: Imo David , Dressel Holger , Byber Katarzyna , Hitzke Christine , Bopp Matthias , Maggi Marion , Bose-O’Reilly Stephan , Held Leonhard , Muff Stefanie
Published: June 2018

Health-risks from contaminated soils are assessed all over the world. An aspect that many risk assessments share is the heterogeneity in the distribution of contaminants. In a preceding study, we assessed potential health-risks for mothers and children living on mercury-contaminated soils in Switzerland using human biomonitoring-values (HBM) and soil samples. We assessed 64 mothers and 107 children who had resided in a defined area for at least 3 months. HBM-concentrations for mercury in urine and hair were measured, a detailed questionnaire was administered for each individual, and more than 4000 individual mercury soil values were obtained in 2015. In this study, we aimed at investigating possible associations of mercury soil- and HBM-values by re-analyzing our data, using predictions of the mercury concentrations at the exact location of the participant’s homes with a kriging approach. Although kriging proved to be a useful method to predict mercury soil concentrations, we did not detect an association between mercury soil- and HBM-values, in agreement with earlier findings. Benefits of geostatistical methods seem to be limited in the context of our study. Conclusions made in our preceding study about potential health risks for the residential population are robust and not altered by the current study.
Mental Well-Being of Older People in Finland during the First Year in Senior Housing and Its Association with Physical Performance
Authors: Lotvonen Sinikka , Kyngäs Helvi , Koistinen Pentti , Bloigu Risto , Elo Satu
Published: June 2018

Growing numbers of older people relocate to senior housing, when their physical or mental performance declines. The relocation is known to be one of the most stressful events in the life of older people and affect their mental and physical well-being. More information about the relationships between mental and physical parameters is required. We examined self-reported mental well-being of 81 older people (aged 59–93, living in northern Finland), and changes in it 3 and 12 months after relocation to senior housing. The first measurement was 3 months and the second measurement 12 months after relocation. Most participants were female (70%). Their physical performance was also measured, and associations between these two were analyzed. After 12 months, mental capability was very good or quite good in 38% of participants, however 22% of participants felt depressive symptoms daily or weekly. Moreover, 39% of participants reported daily or weekly loneliness. After 12 months participants reported a significant increase in forgetting appointments, losing items and difficulties in learn new things. They felt that opportunities to make decisions concerning their own life significantly decreased. Furthermore, their instrumental activities of daily living (IADL), dominant hand’s grip strength and walking speed decreased significantly. Opportunities to make decisions concerning their life, feeling safe, loneliness, sleeping problems, negative thoughts as well as fear of falling or having an accident outdoors were associated with these physical parameters. In addition to assessing physical performance and regular exercise, the various components of mental well-being and their interactions with physical performance should be considered during adjustment to senior housing.
Toxic Effects of Methanol among Illegally Dispatched Workers at Aluminum CNC Cutting Process in Small-Scale, Third-Tier Subcontractor Factories of Smartphone Manufacturers in the Republic of Korea
Authors: Kang Chung Won , Kim Hyunjoo , Shin Kyongsok , Ryu Jia , Jung-Choi Kyunghee , Lim Key Hwan , Kim Jin-Ha
Published: June 2018

An outbreak of occupational methanol poisoning occurred in small-scale, third-tier factories of large-scale smartphone manufacturers in the Republic of Korea in 2016. To investigate the working environment and the health effects of methanol exposure among co-workers in the methanol poisoning cases, we performed a cross-sectional study on 155 workers at five aluminum Computerized Numerical Control (CNC) cutting factories. Gas chromatography measured air and urinary methanol concentration. In the medical examination, symptom surveys, ophthalmological examinations, and neurobehavioral tests were done. Multiple logistic regression analyses controlling for age and sex were conducted to reveal the association of employment duration with symptoms. Air concentrations of methanol in factory A and E ranged from 228.5 to 2220.0 ppm. Mean urinary methanol concentrations of the workers in each factory were from 3.5 mg/L up to 91.2 mg/L. The odds ratios for symptoms of deteriorating vision and central nervous system (CNS) increased according to the employment duration after adjusting for age and sex. Four cases with an injured optic nerve and two cases with decreased neurobehavioral function were founded among co-workers of the victims. This study showed that the methanol exposure under poor environmental control not only produces eye and CNS symptoms but also affects neurobehavioral function and the optic nerve. The role of subcontracting production and dispatched work under poor environmental control was discussed.
The Association between Mental Wellbeing, Levels of Harmful Drinking, and Drinking Motivations: A Cross-Sectional Study of the UK Adult Population
Authors: Appleton Anita , James Rosie , Larsen John
Published: June 2018

Mental well-being and excessive alcohol consumption each represent a significant public health concern, and evidence suggests an association between them. Furthermore, drinking motivations associated with harmful drinking have been studied, but not systematically in the UK population. A representative sample of 6174 UK adults aged 18–75 were surveyed online. Low risk drinkers were found to have higher mental well-being than hazardous, harmful, and, probable, dependence drinkers. Using a hierarchical multiple regression analysis, it was found that just over 5% of the variance in well-being scores was accounted for by the level of harmful drinking and drinking motivation; the most significant contribution was drinking to cope. Among people drinking to cope, those drinking in more harmful ways were statistically significantly more likely to have low well-being compared to less harmful drinkers. In the UK adult population there is a clear association between poor mental well-being and harmful drinking. Furthermore, coping was a significant motivation to drink for many with low mental well-being. While mental well-being was found to be directly linked with levels of harmful drinking, the motivation for drinking was a stronger predictor of mental well-being.
Why Is the Correlation between Crude Oil Prices and the US Dollar Exchange Rate Time-Varying?—Explanations Based on the Role of Key Mediators
Authors: Liao Jia , Shi Yu , Xu Xiangyun
Published: June 2018

Using DCC-GARCH model, this paper finds that, since 1990, the relationship between crude oil prices and the US dollar index is time-varying, demonstrating a process of ‘very weak correlation—negative correlation—enhanced negative correlation—weakening negative correlation’, but the existing research does not provide enough reasonable explanation. Therefore, this paper proposed a ‘key mediating factors’ hypothesis which points out that whether there is a common ‘key mediating factor’ is important source of the time-varying relationship between two assets. We argue that market trend and financial market sentiment undertook the role of ‘key mediating factor’ during the period of the 2002 to the financial crisis and financial crisis to 2013, while other periods lack the ‘key mediating factors’.
A Continuous-Time Inequality Measure Applied to Financial Risk: The Case of the European Union
Authors: D’Amico Guglielmo , Regnault Philippe , Scocchera Stefania , Storchi Loriano
Published: June 2018

In this paper, we apply information theory measures and Markov processes in order to analyse the inequality in the distribution of the financial risk in a pool of countries. The considered financial variables are sovereign credit ratings and interest rates of sovereign government bonds of European countries. This paper extends the methodology proposed in our previous work, by allowing the possibility to consider a continuous time process for the credit rating evolution so that complete observations of rating histories and credit spreads can be considered in the analysis. Obtained results suggest that the continuous time model fits real data better than the discrete one and confirm the existence of a different risk perception among the three main rating agencies: Fitch, Moody’s and Standard & Poor’s. The application of the model has been performed by a software we developed, the full code is available on-line allowing the replication of all results.
Development of a Fingerprint-Based Scoring Function for the Prediction of the Binding Mode of Carbonic Anhydrase II Inhibitors
Authors: Poli Giulio , Jha Vibhu , Martinelli Adriano , Supuran Claudiu T. , Tuccinardi Tiziano
Published: June 2018

Carbonic anhydrase II (CAII) is a zinc-containing metalloenzyme whose aberrant activity is associated with various diseases such as glaucoma, osteoporosis, and different types of tumors; therefore, the development of CAII inhibitors, which can represent promising therapeutic agents for the treatment of these pathologies, is a current topic in medicinal chemistry. Molecular docking is a commonly used tool in structure-based drug design of enzyme inhibitors. However, there is still a need for improving docking reliability, especially in terms of scoring functions, since the complex pattern of energetic contributions driving ligand–protein binding cannot be properly described by mathematical functions only including approximated energetic terms. Here we report a novel CAII-specific fingerprint-based (IFP) scoring function developed according to the ligand–protein interactions detected in the CAII-inhibitor co-crystal structures of the most potent CAII ligands. Our IFP scoring function outperformed the ability of Autodock4 scoring function to identify native-like docking poses of CAII inhibitors and thus allowed a considerable improvement of docking reliability. Moreover, the ligand–protein interaction fingerprints showed a useful application in the binding mode analysis of structurally diverse CAII ligands.
The Direct Involvement of Dark-Induced Tic55 Protein in Chlorophyll Catabolism and Its Indirect Role in the MYB108-NAC Signaling Pathway during Leaf Senescence in Arabidopsis thaliana
Authors: Chou Ming-Lun , Liao Wan-Yu , Wei Wan-Chen , Li Althea , Chu Ching-Ying , Wu Chia-Ling , Liu Chun-Lin , Fu Ting-Han , Lin Lee-Fong
Published: June 2018

The chloroplast relies on proteins encoded in the nucleus, synthesized in the cytosol and subsequently transported into chloroplast through the protein complexes Toc and Tic (Translocon at the outer/inner membrane of chloroplasts). A Tic complex member, Tic55, contains a redox-related motif essential for protein import into chloroplasts in peas. However, Tic55 is not crucial for protein import in Arabidopsis. Here, a tic55-II-knockout mutant of Arabidopsis thaliana was characterized for Tic55 localization, its relationship with other translocon proteins, and its association with plant leaf senescence when compared to the wild type. Individually darkened leaves (IDLs) obtained through dark-induced leaf senescence were used to demonstrate chlorophyll breakdown and its relationship with plant senescence in the tic55-II-knockout mutant. The IDLs of the tic55-II-knockout mutant contained higher chlorophyll concentrations than those of the wild type. Our microarray analysis of IDLs during leaf senescence identified seven senescence-associated genes (SAGs) that were downregulated in the tic55-II-knockout mutant: ASP3, APG7, DIN2, DIN11, SAG12, SAG13, and YLS9. Real-time quantitative PCR confirmed the reliability of microarray analysis by showing the same expression patterns with those of the microarray data. Thus, Tic55 functions in dark-induced aging in A. thaliana by indirectly regulating downstream SAGs expression. In addition, the expression of four NAC genes, including ANAC003, ANAC010, ANAC042, and ANAC075 of IDL treated tic55-II-knockout mutant appeared to be downregulated. Yeast one hybrid assay revealed that only ANAC003 promoter region can be bound by MYB108, suggesting that a MYB-NAC regulatory network is involved in dark-stressed senescence.
Molecular Mechanisms for Regulating Postnatal Ductus Arteriosus Closure
Authors: Hung Yu-Chi , Yeh Jwu-Lai , Hsu Jong-Hau
Published: June 2018

The ductus arteriosus (DA) connects the main pulmonary artery and the aorta in fetal circulation and closes spontaneously within days after birth in normal infants. Abnormal patent DA (PDA) causes morbidities and mortality, especially in preterm infants. Closure of the DA is a complex interactive process involving two events: functional and anatomic closure. Functional closure by smooth muscle contraction was achieved through the regulatory factors of vaso-reactivity. These factors include oxygen sensing system, glutamate, osmolality, prostaglandin E2, nitric oxide, and carbon monoxide. Anatomic closure by vascular remodeling involved several vascular components including endothelium, extracellular matrix, smooth muscle cells, and intraluminal blood cells. Despite advances in understanding of PDA pathogenesis, the molecular mechanism for regulation of DA closure is complex and not fully understood. In this article we review recent evidence regarding the molecular mechanisms of DA closure.
The Reprimo Gene Family: A Novel Gene Lineage in Gastric Cancer with Tumor Suppressive Properties
Authors: Amigo Julio D. , Opazo Juan C. , Jorquera Roddy , Wichmann Ignacio A. , Garcia-Bloj Benjamin A. , Alarcon Maria Alejandra , Owen Gareth I. , Corvalán Alejandro H.
Published: June 2018

The reprimo (RPRM) gene family is a group of single exon genes present exclusively within the vertebrate lineage. Two out of three members of this family are present in humans: RPRM and RPRM-Like (RPRML). RPRM induces cell cycle arrest at G2/M in response to p53 expression. Loss-of-expression of RPRM is related to increased cell proliferation and growth in gastric cancer. This evidence suggests that RPRM has tumor suppressive properties. However, the molecular mechanisms and signaling partners by which RPRM exerts its functions remain unknown. Moreover, scarce studies have attempted to characterize RPRML, and its functionality is unclear. Herein, we highlight the role of the RPRM gene family in gastric carcinogenesis, as well as its potential applications in clinical settings. In addition, we summarize the current knowledge on the phylogeny and expression patterns of this family of genes in embryonic zebrafish and adult humans. Strikingly, in both species, RPRM is expressed primarily in the digestive tract, blood vessels and central nervous system, supporting the use of zebrafish for further functional characterization of RPRM. Finally, drawing on embryonic and adult expression patterns, we address the potential relevance of RPRM and RPRML in cancer. Active investigation or analytical research in the coming years should contribute to novel translational applications of this poorly understood gene family as potential biomarkers and development of novel cancer therapies.
Do Actomyosin Single-Molecule Mechanics Data Predict Mechanics of Contracting Muscle?
Authors: Månsson Alf , Ušaj Marko , Moretto Luisa , Rassier Dilson E.
Published: June 2018

In muscle, but not in single-molecule mechanics studies, actin, myosin and accessory proteins are incorporated into a highly ordered myofilament lattice. In view of this difference we compare results from single-molecule studies and muscle mechanics and analyze to what degree data from the two types of studies agree with each other. There is reasonable correspondence in estimates of the cross-bridge power-stroke distance (7–13 nm), cross-bridge stiffness (~2 pN/nm) and average isometric force per cross-bridge (6–9 pN). Furthermore, models defined on the basis of single-molecule mechanics and solution biochemistry give good fits to experimental data from muscle. This suggests that the ordered myofilament lattice, accessory proteins and emergent effects of the sarcomere organization have only minor modulatory roles. However, such factors may be of greater importance under e.g., disease conditions. We also identify areas where single-molecule and muscle data are conflicting: (1) whether force generation is an Eyring or Kramers process with just one major power-stroke or several sub-strokes; (2) whether the myofilaments and the cross-bridges have Hookean or non-linear elasticity; (3) if individual myosin heads slip between actin sites under certain conditions, e.g., in lengthening; or (4) if the two heads of myosin cooperate.
Investigation of the Influence of Pre-Charged Hydrogen on Fracture Toughness of As-Received 2.25Cr1Mo0.25V Steel and Weld
Authors: Song Yan , Chai Mengyu , Yang Bin , Han Zelin , Ai Song , Liu Yilun , Cheng Guangxu , Li Yun
Published: June 2018

Fracture failure caused by hydrogen embrittlement (HE) is a major concern for the system reliability and safety of hydrogen storage vessels, which are generally made of 2.25Cr1Mo0.25V steel. Thus, study of the influence of pre-charged hydrogen on fracture toughness of as-received 2.25Cr1Mo0.25V steel and weld is of significant importance. In the current work, the influence of hydrogen on fracture toughness of as-received 2.25Cr1Mo0.25V steel and weld was systematically studied. Base metal (BM) and weld metal (WM) specimens under both hydrogen-free and hydrogen-charged conditions were tested using three-point bending tests. Hydrogen was pre-charged inside specimens by the immersion charging method. The J-integral values were calculated for quantitatively evaluating the fracture toughness. In order to investigate the HE mechanisms, optical microscopy (OM) and scanning electron microscopy (SEM) were used to characterize the microstructure of BM and WM specimens. The results revealed that the presence of pre-charged hydrogen caused a significant decrease of the fracture toughness for both BM and WM specimens. Moreover, the pre-charged hydrogen led to a remarkable transition of fracture mode from ductile to brittle pattern in 2.25Cr1Mo0.25V steel.
Electrochemical and Stress Corrosion Mechanism of Submarine Pipeline in Simulated Seawater in Presence of Different Alternating Current Densities
Authors: Wu Wei , Pan Yue , Liu Zhiyong , Du Cuiwei , Li Xiaogang
Published: June 2018

In this study, electrochemical measurements, immersion tests, and slow strain rate tensile (SSRT) tests were applied to investigate the electrochemical and stress corrosion cracking (SCC) behavior of X70 steel in simulated seawater with the interference of different alternating current (AC) densities. The results indicate that AC significantly strengthens the cathodic reaction, especially the oxygen reduction reaction. Simultaneously, hydrogen evolution reaction occurs when the limiting diffusion current density of oxygen reaches, and thus, icorr sharply increases with the increase in AC density. Additionally, when AC is imposed, the X70 steel exhibits higher SCC susceptibility in the simulated seawater, and the susceptibility increases with the increasing AC density. The SCC mechanism is controlled by both anodic dissolution (AD) and hydrogen embrittlement (HE) with the interference of AC.
Mechanical Performance of Multidirectional Buckling-Based Negative Stiffness Metamaterials: An Analytical and Numerical Study
Authors: Ren Chenhui , Yang Deqing , Qin Haoxing
Published: June 2018

Unidirectional, bidirectional and tridirectional Buckling-based Negative Stiffness (BNS) lattice metamaterials are designed by adding prefabricated curved beams into multidimensional rigid frames. Finite Element Analysis models are built, and their mechanical performance is investigated and discussed. First, geometric parameters of the curved beam were systematically studied with numerical analyses and the results were validated by theoretical solutions. Next, within unidirectional designs of different layer numbers, the basic properties of multilayer BNS metamaterials were revealed via quasi-static compressions. Then, the bidirectional and tridirectional designs were loaded on orthogonal axes to research both the quasi-static and dynamic behaviors. For dynamic analysis conditions, simulation scenarios of different impact velocities were implemented and compared. The results demonstrate that the proposed numerical analysis step has accurately predicted the force-displacement relations of both the curved beam and multilayer designs and the relations can be tuned via different geometric parameters. Moreover, the macroscopic performance of the metamaterials is sensitive to the rigidity of supporting frames. The shock force during impact is reduced down below the buckling thresholds of metamaterial designs and sharp impact damage is avoided. The presented metamaterials are able to undergo multiaxial stress conditions while retaining the negative stiffness effect and energy-absorbing nature and possess abundant freedom of parametric design, which is potentially useful in shock and vibration engineering.
Physicochemical and Microbiological Assessment of an Experimental Composite Doped with Triclosan-Loaded Halloysite Nanotubes
Authors: Cunha Diana A. , Rodrigues Nara S. , Souza Lidiane C. , Lomonaco Diego , Rodrigues Flávia P. , Degrazia Felipe W. , Collares Fabrício M. , Sauro Salvatore , Saboia Vicente P. A.
Published: June 2018

This study is aimed at evaluating the effects of triclosan-encapsulated halloysite nanotubes (HNT/TCN) on the physicochemical and microbiological properties of an experimental dental composite. A resin composite doped with HNT/TCN (8% w/w), a control resin composite without nanotubes (HNT/TCN-0%) and a commercial nanofilled resin (CN) were assessed for degree of conversion (DC), flexural strength (FS), flexural modulus (FM), polymerization stress (PS), dynamic thermomechanical (DMA) and thermogravimetric analysis (TGA). The antibacterial properties (M) were also evaluated using a 5-day biofilm assay (CFU/mL). Data was submitted to one-way ANOVA and Tukey tests. There was no significant statistical difference in DC, FM and RU between the tested composites (p > 0.05). The FS and CN values attained with the HNT/TCN composite were higher (p < 0.05) than those obtained with the HNT/TCN-0%. The DMA analysis showed significant differences in the TAN δ (p = 0.006) and Tg (p = 0) between the groups. TGA curves showed significant differences between the groups in terms of degradation (p = 0.046) and weight loss (p = 0.317). The addition of HNT/TCN induced higher PS, although no significant antimicrobial effect was observed (p = 0.977) between the groups for CFUs and (p = 0.557) dry weight. The incorporation of HNT/TCN showed improvements in physicochemical and mechanical properties of resin composites. Such material may represent an alternative choice for therapeutic restorative treatments, although no significance was found in terms of antibacterial properties. However, it is possible that current antibacterial tests, as the one used in this laboratory study, may not be totally appropriate for the evaluation of resin composites, unless accompanied with aging protocols (e.g., thermocycling and load cycling) that allow the release of therapeutic agents incorporated in such materials.
Recognition of M × M by Its Complex Group Algebra Where M Is a Simple K3-Group
Authors: Baniasad Azad Morteza , Khosravi Behrooz
Published: June 2018

In this paper we prove that if M is a simple K3-group, then M×M is uniquely determined by its order and some information on irreducible character degrees and as a consequence of our results we show that M×M is uniquely determined by the structure of its complex group algebra.