bluuebunny/crossref_metadata_2025 huggingface dataset:
Polyphyllin I suppressed the apoptosis of intervertebral disc nucleus pulposus cells Induced By IL-1 β by miR-503-5p/Bcl-2 axis
Authors: Yuan Lei , Miao Hui , Ding Heng , Zhang Fan , Lou Zhen-kai , Li Xing-Guo
Published: March 2023

Background:no studies have shown the role and underlying mechanism of PPI-mediated anti- apoptosis activity in NP cells. We aimed to evaluate the effects of PPI in IL-1β-induced apoptosisin vitro.Methods:CCK-8 assay was used to detect the cell viability, cell apoptosis evaluated by double-stained flow cytometry (FITC Annexin V/PI), the expression of miRNA- 503-5p was quantified by qRT-PCR, the expression of Bcl-2, Bax and Cleaved caspase-3 were quantified by Western blot, Dual-luciferase reporter gene assay was used to detect the targeting relationship between miR-503-5p and Bcl-2.Results:PPI at 40 μg·mL-1markedly promoted the activity of NP cells (P＜0.01). Also, PPI reduced the level of apoptosis and enhanced activity induced by interleukin-1β( IL-1β) in NP cells (P＜0.001，0.01). PPI treatment significantly inhibited the expression of apoptosis-related protein Bax, Cleaved Caspase-3 (P＜0.05, 0.01), and enhanced the level of anti-apoptotic protein Bcl-2 (P＜0.01). The activity of NP cells was significantly decreased and the apoptosis rate of NP cells was increased under IL-1β treatment (P＜0.01， 0.001). Moreover, miR-503-5p was highly expressed in IL-1β-injured NP cells (P＜0.001). Furthermore, the effect of PPI on NP cell activity and apoptosis in IL-1β treatment was dramatically reversed by the overexpression of miR-503-5p (P＜0.01，0.01). The targeted binding of miR-503-5p to the 3'UTR of Bcl-2 mRNA was confirmed by dual luciferase reporter gene assays (P＜0.05). In further experiments, compared with miR-503-5p mimics, the effects of PPI on IL-1β-injured NP cell activity and apoptosis were greatly reversed by the co-overexpression of miR-503-5p and Bcl-2 (P＜0.05，0.05).Conclusion:PPI suppressed the apoptosis of intervertebral disc nucleus pulposus cells induced by IL-1β via miR-503-5p/Bcl-2 molecular axis.
A novel approach for congestive heart failure and arrhythmia classification using OD- 1D-LBP with LSTM and 1D-CNN
Authors: TEKİN Hazret , KAYA Yılmaz
Published: March 2023

Congestive heart failure (CHF) and heart rhythm disorders (ARR) are known to be the most important heart diseases of the last decades, which have had negative effects on human health directly or indirectly. The early diagnosis of these types of heart diseases and rapid and practical medical intervention is very vital. For the diagnosis of such diseases, it is so difficult for doctors to analyze long ECG signals quickly and detect instantaneous parameter changes in the ECG signal with manual observation technique. Therefore, it is necessary to develop efficient Computer Aided Diagnosis (CAD) systems for the early diagnosis of diseases such as ARR and CHF. For this purpose, within the scope of digital signal processing, various statistical and mathematical algorithms have been developed to extract features from signals and various machine learning methods are applied for classification. In this study, a new method is proposed to analyze and classify the ECG signals of CHF, ARR ,and NSR (Normal Sinus Rhythm). This method is based on the local-binary-pattern (LBP) algorithm and is called Orthogonal Difference One Dimensional Local Binary Pattern (OD-1D-LBP). This method is an approach that uses binary information obtained by comparing each point on the signal with its neighbors. Histograms of new signals that are obtained from the proposed method (OD-1D-LBP) are given as input to Long Short-Term Memory (LSTM) and one-dimensional Convolutional Neural Networks (1D-CNN) for classification. If 70% of the input data is applied as training data and 30% as test data, the accuracy rates are obtained at 98.63% for LSTM and 98.86% for 1D-CNN. If only ACF and ARR data are classified; the accuracy rate is obtained at 98.94% for LSTM; and 97.40% for 1D-CNN. Similarly, when ACF and NSR ddataare classified; the accuracy rate is obtained at 99.4% for LSTM; and 98.9% for 1D-CNN. In case ARR and NSR data are classified; the accuracy rates are obtained at 99.2% for LSTM; and 95.2% for 1D-CNN.
Source recovery by analytical maximization of phase-shifted kurtosis for the mixtures of noisy and noiseless signals
Authors: SMATTI El mouataz billah , ARAR Djemai
Published: March 2023

This manuscript presents a work that provides a study as well as a simple analytical solution for solving the blind source separation problem (BSS) for noiseless and noisy linear mixing of statistically independent stationary and nonstationary signals. The study is based on the exploitation of the probabilistic characteristics of the mixed signals by using the statistics of the second order and the fourth order for the completion of the separation. The proposed solution consists mainly of two steps based on the concept of the geometric solution. For the case of the mixture of two sources (2×2), the first step aims to transform the dependent signals into orthogonal signals (whitening) via the principal component analysis (PCA) principle. After the application of the PCA and in order to complete the statistical independence of the two uncorrelated signals, the second step aims to determine an adequate rotating angle that leads directly to the separation, and this angle is determined in this work analytically by the simple calculation of the phase shift of a sinusoidal objective function based on the sum of the kurtosis of the whitened signals. In the case of several sources (n×n), the solution (2×2) can be applied by a simple generalization which leads to the global separation. Whether for the noisy or noiseless case, the results obtained prove the reliability and efficiency by applying this analytical solution to achieve the desired objective, in particular by comparing the proposed algorithm with the application of two other separation algorithms, one of which involves the application of optimization techniques
Household environment and animal fecal contamination are critical modifiers of the gut microbiome and resistome in young children from rural Nicaragua
Authors: Mills Molly , Lee Seungjun , Piperata Barbara A. , Garabed Rebecca , Choi Boseung , Lee Jiyoung
Published: March 2023

Background: Early life plays a vital role in the development of the gut microbiome and subsequent health. While many factors that shape the gut microbiome have been described, including delivery mode, breastfeeding, and antibiotic use, the role of household environments is still unclear. Furthermore, the development of the gut antimicrobial resistome and its role in health and disease is not well characterized, particularly in settings with water insecurity and less sanitation infrastructure.
Results: This study investigated the gut microbiomes and resistomes of infants and young children (ages 4 days-6 years) in rural Nicaragua using Oxford Nanopore Technology’s MinION long read sequencing. Differences in gut microbiome and resistome diversity and antibiotic resistance gene (ARG) abundance were examined for associations with host factors (age, sex, height for age z-score, weight for height z-score, delivery mode, breastfeeding habits) and household environmental factors (animals inside the home, coliforms in drinking water, enteric pathogens in household floors, fecal microbial source tracking markers in household floors). We identified the anticipated association of higher gut microbiome diversity with participant age. There were also positive correlations between ruminant and dog fecal contamination of household floors and gut microbiome diversity. However, greater abundances of potential pathogens were identified in the gut microbiomes of participants with higher fecal contamination on their household floors. Path analysis revealed that water quality and household floor contamination independently and significantly influenced gut microbiome diversity when controlling for age. These gut microbiomes contained diverse resistomes, dominated by multidrug, tetracycline, macrolide/lincosamide/streptogramin, and beta-lactam resistance. We found that the abundance of ARGs in the gut decreased with age. The bacterial hosts of ARGs were mainly from the family Enterobacteriaceae, particularly Escherichia coli.
Conclusions: This study identified the role of household environmental contamination in the developing gut microbiome and resistome of young children and infants with a One Health perspective. We found significant relationships between host age, gut microbiome diversity, and the resistome. Understanding the impact of the household environment on the development of the resistome and microbiome in early life is essential to optimize the relationship between environmental exposure and human health.
Changes in the symptom clusters of elderly patients with lung cancer over the course of postoperative rehabilitation and their correlation with frailty and quality of life: a longitudinal study
Authors: Chen Keyu , Yang Dandan , Li Fang , Gao Lihong , Tian Yali , Xu Bin , Xu Xinyi , Xu Qin , Cao Juan
Published: March 2023

Objective: To explore changes in the symptom clusters of elderly patients with lung cancer at different time points after surgery, and to analyze correlations between cluster severity, frailty and quality of life.
Methods: A longitudinal study was performed from August 2020 to June 2021 that included elderly patients with lung cancer who were operated upon at Jiangsu Province Hospital. Data were collected using the Chinese Tilburg Frailty Indicator, the MD Anderson Symptom Inventory and the Quality of Life-Core scale.
Results: According to exploratory factor analysis, a total of 5 symptom clusters were found and three of them (Global mental function symptom cluster, special mental function symptom cluster and respiratory function symptom cluster) were persistent. The incidence of the top four symptoms changed at different time points. The severity of symptom clusters at different time points was positively correlated with frailty and negatively correlated with quality of life.
Conclusions: Findings may provides a reference for medical staff to implement symptom management in elderly patients with lung cancer after surgery. Frailty may be an important variable affecting the severity of symptom cluster and quality of life of patients.
Existence of periodic traveling waves in a nonlocal convection-diffusion model with chemotaxis and delay effect
Authors: Liu Kaikai , Guo Shangjiang
Published: March 2023

We focus upon the existence of periodic traveling waves in a nonlocal reaction-diffusion model with chemotaxis and nonlocal delay effect. Based on the perturbation method, the existence of periodic traveling waves with large wave speed are obtained by the Lyapunov-Schmidt reduction and the implicit function theorem. The trick of the proof is to treat the wave profile as a solution of an operator in a suitable Banach space.
Mathematics Subject Classification (2000) 35K57 · 34K05
Assessing the ChatGPT Accuracy Through Principles of Statistics Exam: A Performance and Implications
Authors: AL-Qadri Abdo Hasan , Ahmed Salah A.M.
Published: March 2023

This report aimed to evaluate the performance of ChatGPT, a large language model, in understanding and answering questions related to principles of statistics. 15 questions were presented to the model, with correct answers obtained in 93% of cases. Of these, 11 questions were answered correctly on the first attempt (73%), one question required two attempts (7%), and two questions required multiple attempts (13%). One question was not answered correctly (7%). These results suggest that ChatGPT has a strong understanding of statistical principles, but may require further training on certain specific concepts. More recommendations were reported to avoid the negative consequences of ChatGPT on the assessment process in education.
CONTRIBUTION TO THE EXPLANATION OF THE SEMI-ANNUAL ANOMALY OBSERVED IN THE INTERTROPICAL ZONE USING THE CRITICAL FREQUENCIES FOF2 EXTRACTED DURING THE SUNSPOT CYCLES 20, 21 AND 22 AT THE OUAGADOUGOU STATION
Authors:   Laboratoire de Recherche en Energetique et Meteorologie de lEspace (LAREME), UFR-ST, Universite Norbert ZONGO, BP 376 Koudougou, Burkina Faso., Abdoul-Kader Segda , Doua Allain Gnabahou ,   Laboratoire de Recherche en Energetique et Meteorologie de lEspace (LAREME), UFR-ST, Universite Norbert ZONGO, BP 376 Koudougou, Burkina Faso., Salfo Kabore ,   Laboratoire de Recherche en Energetique et Meteorologie de lEspace (LAREME), UFR-ST, Universite Norbert ZONGO, BP 376 Koudougou, Burkina Faso.
Published: March 2023

The objective of this paper is to bring a mathematical resolution to the semi-annual anomaly of the critical frequencies foF2 which presents itself as a sinusoid.Thus, we posit two postulates about the average and monthly power of the solar radiation which would induce the semi-annualanomaly.This power result of the power caused by the angle of attack of the suns rays and that imparted to the Earth-Solar distance variable due to the fact that the orbit of the Earth is elliptical. Thus the monthly variations of the critical frequencies foF2 can be explained in these terms:If the critical frequencies foF2 are increasing from the solstices to the equinox peaks it is thus respectively because the power is increasing on the sole effect of the power with respect to from the winter solstice to the peak of the spring equinox and on the combined effects of the two powers and which are all increasing for what from the summer solstice to the peak of the autumn equinox. If the critical frequencies foF2 are decreasing from the peaks of the equinoxes to the solstices it is thus respectively because the power is decreasing on the combined effects of and which are all decreasing with respect to the spring equinox to summer solstice peak and on the sole effect of the power with respect to the fall equinox to winter solstice peak.Finally the winter anomaly, the semi-annual anomaly and the equinoctial asymmetry would be explained according to the in-phase or out-of-phase outcome of the two powers and at peaks or solstices.
A REVIEW OF BREAKING SEED DORMANCY IN HAWTHORNS (CRATAEGUSSPP.)
Authors:   Horticulture Department, College of Agricultural Engineering Sciences, University of Sulaimani, SulaimanyahCity, Kurdistan Region, Iraq., Akram Mohammed Aram
Published: March 2023

Propagation of hawthorns (Crataegusspp.) is difficult, and vegetative methods are not responsive in a sufficient manner. So, seed propagation is prevalently used to propagate hawthorns. However, hard endocarp and embryo dormancy restrict the germination of hawthorns. To overcome these restrictions, many treatments have been tested in the researches. Some of them were magnificent and others ineffective. It has been resolved that warm and cold stratification are the best for breaking dormancy in seeds of hawthorns. Thus far, no substitution has been found for warm and cold stratification treatment to release the seeds of hawthorns from dormancy, from the conventional point of view. Besides, combination with other factors may reduce the period and temperature degrees of warm and cold stratification, for instance, species, eliminating endocarp, treatment with growth regulators, and chemical scarification. In this review, the results of methods will be referred to that used in the studies to break seed dormancy in hawthorns.
INDIAN STATES LANGUAGE POLICIES: GENESIS OF CHALLENGES FACED BY HINDI AND ITS FUTURISTIC IMPLICATIONS
Authors: Chaudhary Shubhda
Published: March 2023

The paper starts with defining what language is and what linguistic consciousness means in the context of the theoretical work done by Edmund Husserl in understanding the intentionality of a language. The issue of mother tongue language is also elucidated, especially in the context of the Westphalian nation-states that emerged in the Western European countries. This Westphalian Treaty played a pivotal role in creating one nation, one official language discourse which has been thoroughly defunct in multi-lingual, socio-politically complex realties of the Indian State. While explaining how English was made the official language and the reasons behind it during the British Empires reign in India, the paper excavates the conflicts that took place in the narrow social base of English, Hindi and Hindustani. While explaining the historical genesis of the Hindi language, both in terms of negotiation and mutual co-dependence, the emergence of Vernacular language of Hindustan is discussed in detail. As the paper describes the presence of various kinds of Hindi in the socio-political complex realm of Indias national identity, it also elucidates why Hindi continues to survive, in spite of the anti-Hindi agitations. The contribution of organisations in this process are also debated. Towards the end, the paper tries to frame the genesis of Hindi and the natural conflict that it entails in the domination of minority languages, by tracing the language policies of the Indian constitution and thus, explaining why these challenges would continue, thereby marking key futuristic projections.
KNOWLEDGE, ATTITUDE AND PRACTICES TOWARDS BREAST FEEDING AMONG LACTATING MOTHERS IN KING GEORGE HOSPITAL, A TERTIARY CARE CENTER
Authors:   Department of Obstetrics and Gynaecology, King George Hospital, Andhra Medical College, Visakhapatnam, Andhra Pradesh, India., Satyavani Nandigama , Chandrakala Garugubilli ,   Department of Obstetrics and Gynaecology, King George Hospital, Andhra Medical College, Visakhapatnam, Andhra Pradesh, India., Ramya Pathuri ,   Department of Obstetrics and Gynaecology, King George Hospital, Andhra Medical College, Visakhapatnam, Andhra Pradesh, India.
Published: March 2023

Background: Exclusive breastfeeding (EBF) is recommended for the first sixmonths of age by the World HealthOrganization. Mothers good knowledge andpositive attitude play key roles in the process of exclusivebreastfeeding practices. Objectives:The objective of the present study was to examine theknowledge and attitude towards breast feedingpractices among lactating mothers in inpatient wards in the Department of Obstetrics and Gynaecology, King George Hospital, Visakhapatnam. Methodology: A cross sectional descriptive study was carried out amongrandomly selected postnatal mothers at Inpatient wards in the Department of obstetrics, King George Hospital, a tertiary care center in Visakhapatnam. Data was collected through face-to-face interview using astructuredquestionnaire. Results: Our findings revealed that a majority 86%(n=284) of the mothers werebreastfeeders.About 58%(n=191) believed that colostrum is nutritionally beneficial to child. About 46%(n=152) initiated breast feeding within an hour. 70%(n=231) of mothers felt it should be given for >6 months. 83%(n=274) of mothers were against pre lacteal feeds. Mothers have goodknowledge and practices on breast feeding andfair attitude toward breast feeding. Conclusion: The breastfeeding practices in India still can be improved, although women were aware of the exclusive breastfeeding and its importancethey did not practice this to the fullest. We suggest access to nutrition information pertaining to breastfeeding can be strengthened further through various community programmes. Individual breastfeeding counsellingand health education on nutrition to the mother by health workers should be promoted.
LES OVAIRES POLYKYSTIQUES: PRISE EN CHARGE DE L INFERTILITE EN DEHORS DES INDICATIONS DE FIV
Authors:   Service de Gynecologie Obstetrique de Centre Hospitalier Mohammed VI dOujda au Maroc., Stimou Sanae , Taheri Hafsa ,   Service de Gynecologie Obstetrique de Centre Hospitalier Mohammed VI dOujda au Maroc., Saadi Hanane ,   Service de Gynecologie Obstetrique de Centre Hospitalier Mohammed VI dOujda au Maroc., Mimouni Ahmed ,   Service de Gynecologie Obstetrique de Centre Hospitalier Mohammed VI dOujda au Maroc.
Published: March 2023

Le syndrome des ovaires polykystiques (SOPK) est une affection frequente qui touche 4 a 11 % des femmes. Cest la premiere endocrinopathie chez la femme jeune en ÃƒÂƒÃ‚Â¢ge de procreer. Elle Constitue la premiere cause dinfertilite par anovulation. La physiopathologie de ce syndrome est complexe. Elle associe une hyperandrogenie ovarienne a des troubles de la maturation folliculaire avec anovulation et hypofertilite. Une insulino-resistance, non indispensable au diagnostic, est le plus souvent presente majorant en fait lhyperandrogenie et entrainant a long terme des risques metaboliques, cardiovasculaires et carcinologiques. La prise en charge de linfertilite du SOPK passe donc par le retablissement de lovulation, en ayant bien sÃƒÂƒÃ‚Â»r verifie letat tubaire et le spermogramme du conjoint. Si les trompes sont permeables et le spermogramme compatible avec une conception spontanees, on proposera a la patiente une induction de lovulation simple. Dans le cas contraire, on posera lindication dune technique daide medicale a la procreation(AMP), insemination ou technique de fecondation in vitro (FIV ou ICSI) selon les facteurs dinfertilite associes. On dispose dune litterature abondante sur la prise en charge du trouble de lovulation lie au SOPK. La place de chacun fait toujours actuellement debat et est dautant plus difficile a determiner que le SOPK est un syndrome heterogene, incluant des phenotypes variables plus ou moins severes. Lobjectif de cet article est de rappeler les principes de prise en charge therapeutique de linfertilite chez les femmes atteintes de SOPK en dehors de la FIV.
EVALUATION OF PROGNOSTIC SIGNIFICANCE OF CRP, IONIC CALCIUM,AND SERUM ALBUMIN IN ACUTE PANCREATITIS
Authors:   Junior Resident, Hind Institute of Medical Sciences Safedabad, Barabanki., Nath Abantika , Bhatia Sanjiv ,   MCh & Head of dept of Plastic Surgery, Hind Institute of Medical Sciences Safedabad, Barabanki., a Neharika ,   Associate Professor, Dept Of General Surgery, Hind Institute of Medical Sciences Safedabad, Barabanki., Goel V.K ,   Professor & Head of Dept Of General Surgery, Hind Institute of Medical Sciences Safedabad, Barabanki., Debnath Rajib ,   Assistant Professor,Tripura Medical College & DR BRAM Teaching Hospital.
Published: March 2023

Introduction: Acute pancreatitis is defined as an inflammatory process of pancreas with possible peripancreatic tissue involvement and multi organ dysfunction syndrome with increasing mortality rate. In response to initial insult, acinar cells release proinflammatory cytokines, such as TNF a, IL-1, 2 and 6, and anti-inflammatory mediators such as IL-10 and IL-1 receptor antagonist. Acute pancreatitis is best diagnosed clinically in a patient presenting with 2 of the 3 following criteria.(1) Symptoms consistent with pancreatitis,(2) Serum lipase or amylase levels more than 3 times the laboratorys upper range of normal, and (3) Radiologic features suggestive of pancreatitis, usually using CECT. Usually, the first two criteria are present, and CECT is not required for diagnosis. Aims & Objective: 1. To determine the prognosis of acute pancreatitis on the basis of quantitative value of CRP,SERUM ALBUMIN AND IONIC CALCIUM in admitted patients of HIMS on day of admission and after 48hours.2. To assess the severity of acute pancreatitis as mild,moderate,severe form(as per REVISED ATLANTA CLASSIFICATION 2013) and compare it with values of CRP,SERUM ALBUMIN AND IONIC CALCIUM. Methodology: The study will be conducted over a period of 18months (January 2021 to July 2022) in which all patients coming to General Surgery department at Hind Institute of Medical Sciences, Barabanki, UP with diagnosis of acute pancreatitis will be included. Result: We found that male population was higher than the female population. which was statistically significant. Higher number of patients had Pain in Abdomen Since 3 Days and patients were Alcoholic but this was statistically significant.Association of CRP Value with Day is statistically significant.Association of serum albumin value with Day is statistically significant. Association of Ionic Calcium value with Dayis statistically significant. This study shows that there is relation between se.CRP,se.Albumin and ionic calcium to assess the severity of Acute Pancreatitis.
A DESCRIPTIVE CROSS-SECTIONAL OBSERVATIONAL STUDY ON ASSESSMENT OF PATIENTS KNOWLEDGE, ATTITUDE AND PRACTICE ON HYPERTENSION AT A TERTIARY CARE HOSPITAL
Authors:   Assistant Professor, Department of Pharmacy Practice, Thanthai Roever College of Pharmacy (Affiliated to The Tamil Nadu Dr.M.G.R Medical University), Perambalur, Tamil Nadu, India., P. Suriyakala , Billah A. Mohathasim ,   Professor, Department of Pharmacy Practice, Sri Ramachandra Faculty of Pharmacy, SRIHER, Chennai., H. Rajamohamed ,   Assistant Professor, Department of Pharmacy Practice, Thanthai Roever College of Pharmacy (Affiliated to The Tamil Nadu Dr.M.G.R Medical University), Perambalur, Tamil Nadu, India., Akram Ali S. Mohamed ,   Assistant Professor, Department of Pharmacy Practice, Thanthai Roever College of Pharmacy (Affiliated to The Tamil Nadu Dr.M.G.R Medical University), Perambalur, Tamil Nadu, India., A. Sathya ,   Assistant Professor, Department of Pharmacology, Thanthai Roever College of Pharmacy (Affiliated to The Tamil Nadu Dr.M.G.R Medical University), Perambalur, Tamil Nadu, India., K. Vijayalakshmi ,   Associate Professor, Department of Pharmacognosy, Thanthai Roever College of Pharmacy (Affiliated to The Tamil Nadu Dr.M.G.R Medical University), Perambalur, Tamil Nadu, India.
Published: March 2023

Introduction: Hypertension is a strong independent risk factor for coronary and cerebrovascular diseases, as well as for heart failure, atrialfibrillation and chronic renal failure, thus substantially contributing to the global burden of disease. Moreover, it is well known that reducing blood pressure (BP) in hypertensive patientsis associated with a significant reduction in the rate of cardiovascular complications and adecline in renal function. Aim: To assess the patients knowledge, attitude and practice (KAP) and to create awareness about hypertension among hypertensive patients. Objectives: To evaluate the current situation and differences in knowledge, attitude and practices regarding hypertension and to create awareness of hypertension by giving verbal counseling to hypertensivepatients. Conclusion: Our study signifies that patients require support and guidance for practicing better disease management. Hence we conclude that aclinical pharmacist can play major role in improving patients knowledge and adherence bypatient education, developing maintenance of diet and exercise improved the patients practice activities. Clinical activities such as patient counseling, Home Medication Review, Pharmaceutical care program help to increase the patients practice in disease management.
CASE REPORT- PRE AURICULAR SWELLING PRESENTED AS DERMATOFIBROSARCOMA
Authors:   Research Scholar, Junior Resident in Department of Otorhinolaryngolgy at SDM College of Medical Sciences and Hospital, Manjushree Nagar, Sattur Dharwad 580001 Karnataka., S. Rekharaj , J. Roshan ,   Professor in Department of Otorhinolaryngolgy at SDM College of Medical Sciences and Hospital, Manjushree Nagar, Sattur Dharwad 580001 Karnataka., Naik Ashok ,   Professor in Department of Otorhinolaryngolgy at SDM College of Medical Sciences and Hospital, Manjushree Nagar, Sattur Dharwad 580001 Karnataka.
Published: March 2023

Background: Dermatofibrosarcoma protuberans a rare soft tissue tumour that involves the dermis, subcutaneous fat, and in rare cases muscle and fascia. Case Report: 34 yr old female patient presented with history of swelling in front of right ear since 2 years, associated with pain since 2 weeks , HRUSG neck reported as Neoplastic pathology and FNAC reported as benign spindle cell tumor. Patient underwent surgical excision of tumour. Frozen section sent was reported as synovial cell sarcoma or schwannoma. Hence on table superficial parotidectomy done. HPE showed Dermatofibrosarcoma protuberans . Conclusion: Dermatofibrosarcoma protuberans is considered intermediate-grade malignancy with low likelihood of metastasis hence treatment is complete surgical excision. As chance of recurrence is high regular follow up required.
PREVALENCE OFINTERNET ADDICTION AND ITS CORRELATION WITH DEPRESSION, ANXIETY, AND STRESS AMONG YOUTH
Authors:   Resident Doctor, Department of Community Medicine, Government Medical College, Aurangabad., Badgujar Shraddha , M. Kuril Bina ,   Associate Professor, Department of Community Medicine, Government Medical College, Aurangabad., Doibale M.K. ,   Professor & HOD, Department of Community Medicine, Government Medical College, Aurangabad., Shingru Pratiksha ,   Undergraduate Research Associate.
Published: March 2023

Background: Internet isanessential aspect of human life in current age. It forms an undeniablepart of educational, professional, andpersonal life. Internet addiction is currently under consideration to be included under substance abuse section of diagnostic and statistical manual of mental disorders. This study was conducted with a rationale of understanding different facets of this emerging mental health problem.Convenience sampling was done. Data was collected by means of a pre-formed, structured questionnaire. Internet addiction assessment scale and Depression, Anxiety, Stress Scale-21 (DASS21) was used.Pearsons correlation test was used to evaluate the correlation.A sample size of 170 participants was achieved. Mean age was 21.3 + 4.4 years.Prevalence of internet addiction was 45%. In this study, internet addiction test score had a positive correlation with depression, anxiety, and stress (p<0.05).The positive correlation between internet addiction and various psychopathologies shows that internet addiction if present increases their incidence. However, temporal causation needs further evaluation.
Vivências de servidores em um contexto de desflexibilização da jornada de trabalho
Authors: Souza Gustavo Carvalho , Guimarães Ludmila De Vasconcelos Machado , La Falce Jefferson Lopes
Published: March 2023

A presente pesquisa buscou compreender as vivências dos servidores Técnico-Administrativos em Educação (TAEs) de uma Instituição Federal de Ensino Superior (IFES), em um contexto de desflexibilização da jornada de trabalho, à luz da teoria da Psicodinâmica do Trabalho. O processo de desflexibilização é compreendido aqui como um retorno à jornada de trabalho que uma vez fora flexibilizada. Metodologicamente, recorreu-se ao uso da triangulação metodológica devido à complexidade do estudo. Optou-se pela aplicação do Inventário sobre Trabalho e Riscos de Adoecimento (ITRA) para compreensão do cenário geral da instituição e, posteriormente, constituiu-se um grupo focal para a coleta das informações qualitativas. Para análise dos dados quantitativos, foi utilizada a estatística descritiva e, para os dados qualitativos, a análise de conteúdo. A pesquisa confirmou empiricamente que as vivências de sofrimento patogênico têm se estabelecido no trabalho efetivo dos TAEs, sendo potencializadas pelo processo de desflexibilização da jornada, e que a instituição opera promovendo altos riscos de adoecimento desses profissionais.
Formulation and Development of Hyaluronic Acid based Gel with Ketoconazole-Loaded Nanostructured Lipid Carriers in Fungal Infection
Authors: Raut Sadhana , Gargate Nupur , Ugale Sharddha , Gujar Kishor N. , Kapare Harshad
Published: March 2023

Background:

Ketoconazole is an imidazole ring containing antifungal agent used in the
treatment of systemic fungal infections. It acts by blocking the synthesis of ergosterol, an essential
component of the fungal cell membrane.

Objective:

The purpose of this work is to construct skin targeting ketoconazole nanostructured
lipid carriers (NLCs) loaded hyaluronic acid (HA) modified gel to minimize side effects and provide
a controlled release.

Methods:

The NLCs were prepared using emulsion sonication method and their optimized batches
were characterized for X-ray diffraction, scanning electron microscopy and fourier transform infrared
spectroscopy study. These batches were then incorporated into HA containing gel for convenient
application. The final formulation was compared with the marketed formulation for studying
its antifungal activity and drug diffusion.

Results:

Ketoconazole NLCs loaded hyaluronic acid formulation was successfully developed with
desirable formulation parameters by using 23 Factorial design. In vitro release study of developed
formulation showed prolonged drug release (up to 5 hrs) while ex vivo drug diffusion study on
human cadaver skin showed better drug diffusion as compared with marketed formulation. Moreover,
the release study and diffusion study results reflected the improvement of antifungal activity
of the developed formulation against Candida albicans.

Conclusion:

The work suggests that ketoconazole NLCs loaded HA modified gel provides prolonged
release. The formulation also has good drug diffusion and antifungal activity and thus can
act as a promising carrier for topical delivery of ketoconazole.
Sida rhombifolia Linn., A Traditional Herb: A Review of its Phytochemistry
and Pharmacology
Authors: Ahirrao Pallavi
Published: March 2023

Ancient systems of medicine such as Ayurveda and others in India have contributed vast
knowledge to develop herbal medicines over the years. The WHO has also recognized the importance
of drugs developed from natural products. Sida rhombifolia Linn. known as ‘Mahabala’ is
ethnomedicinal plant of Malvaceae. Traditionally S. rhombifolia was used in India in the form of
extracts/powder/paste by tribal populations in India for treating common ailments like cough and
cold, fever, stomach, kidney and liver disorders, inflammations, etc. The present review describes a
detailed overview of traditional medicinal uses, phytochemistry and ethnopharmacological studies
of S. rhombifolia. Several phytoconstituents from S. rhombifolia have been reported to exhibit
pharmacological activities in vivo and/or in vitro bioassays. Validation of ethnomedicinal uses of
medicinal plants by modern scientific approaches is essential for ensuring safe and effective utilization
of herbal medicines.
Meshless Improved Algorithm for Ion Flow Field in Large-Span AC-DC
Parallel Lines
Authors: Zhang Ruiyong , Cai Chenlin , Xi Haibo , Yao Cheng
Published: March 2023

Background:

The research in this paper aims to address the effect of large-span AC lines
on ion currents in parallel DC lines. This paper proposes an algorithm for solving mixed ion flow
fields based on meshless radial point interpolation, which can accurately solve the ion flow field of
large-span AC-DC parallel lines.

Methods:

The shape function of the traditional meshless method is modified by polynomial radial
point interpolation so that the shape function can satisfy the Kronecker-δ function property at the
point where the boundary constraints are to be imposed so as to meet the requirements of directly
applying the boundary constraints; Combined with the influencing factors of the AC line on the
mixed ion flow field, the mixed ion flow field and the ion current density value was obtained.

Results:

Using the proposed algorithm, the relative error of ion current density can be reduced to
4.5%, and the relative error of ion flow field can be reduced to 24%.

Conclusion:

The simulation results are consistent with the measurement results, which proves the
correctness and practicability of the mixed ion flow field solution algorithm based on meshless radial
point interpolation.
Determinación del coeficiente convectivo de transferencia de calor en el proceso de escaldado de mora castilla (rubus glaucus benth) por el método de elementos finitos
Authors: Avilez Montes Yomar , Romero Martinez Maria , Ortega Quintana Fabian , Lopez Acosta Emiro , Lopez Acosta Omar
Published: March 2023

La transferencia de calor en la mora de Castilla (Rubus glaucus Benth), la cual es una baya de aspecto elipsoidal formada por pequeñas drupas adheridas a un receptáculo. Esta fruta presenta un modelo geométrico irregular, para solucionar el modelo matemático de la transferencia de calor de cuerpos irregulares se utilizan los métodos numéricos y uno de los más aplicados es el método de los elementos finitos, el cual divide al objeto en elementos pequeños y así se resuelve el problema planteado como una serie de ecuaciones algebraicas simultáneas en lugar de requerir la solución de las ecuaciones diferenciales complejas, para esto se aplican modelos computacionales integrados a un software. El objetivo de la presente investigación fue determinar el coeficiente convectivo de transferencia de calor h en el proceso de escaldado de la mora Castilla con agua, como fluido de calentamiento, a temperatura de 70°C, 80°C y 90°C. La medición de la temperatura del centro geométrico de las moras Castilla se realizó con termopares tipo K referencia NI USB-TC01 (National Instruments) y la simulación del modelo del proceso de escaldado fue realizada con el software COMSOLTM Multiphysics 3.5 (versión evaluación). El coeficiente convectivo (h) se determinó resolviendo un problema de optimización para encontrar el mínimo error medio relativo absoluto entre la temperatura del centro geométrico experimental y la temperatura del centro geométrico obtenida por simulación del modelo. Los valores obtenidos de h para 70°C, 80°C y 90°C fueron 504,5 W/m2°C, 382,5 W/m2°C y 567 W/m2°C, respectivamente, y el error medio relativo absoluto estuvo entre 0,4% y 3,75%.
Proposta de um algoritmo de recomendação usando uma rede bayesiana no health simulator
Authors: Bez Marta , M. Barros Paulo R. , Lima Alessandro , Helwanger Fernando , Reidel Diego
Published: March 2023

Este artigo apresenta o projeto Health Simulator no contexto de inteligência artificial, no que se refere ao armazenamento do conhecimento especializado na área da saúde e estratégia pedagógica, que permite o auxílio ao aluno no seu processo de aprendizagem. Para tanto é apresentada a teoria de redes bayesianas, sistemas de recomendação, o projeto Health Simulator e a proposta de aplicação das técnicas utilizadas neste ambiente.
Ontomastitis: ontología para la mastitis bovina
Authors: Ballesteros Ricaurte Javier Antonio , González Sanabria Juan Sebastián , Cáceres Castellanos Gustavo
Published: March 2023

Mastitis is a cow disease caused by an infection in the mammary gland due to bacteria entering through the skin. This disease can have repercussions directly on the quality of the milk and thus, on the incomes of the producers. Therefore, the objective of this work was creating ontology with mastitis in order to provide a tool for veterinarians, which helps in the search of information related to different cases and treatments. Methontology and Protégé methodologies were respectively used in order to develop and formalize the ontology. As a result of the process, it was obtained an ontology integration model for mastitis, with an information system for medical diagnose.
Seguridad Alimentaria En La Población Desplazada De La Vereda Uribe Uribe Del Municipio De Lebrija
Authors: Agualimpia Afanador Roberto , Álvarez Flórez Doris , Caballero Pérez Luz Alba
Published: March 2023

La Seguridad Alimentaria plena es el propósito principal de un país, que debe producir alimentos sanos, nutritivos, de buena calidad, para que su población tenga una vida sana y activa, de manera que se puedan desenvolver eficazmente en sus actividades diarias. El presente estudio presenta la determinación el grado de seguridad alimentaria de los hogares de población desplazada de la vereda Uribe Uribe del municipio de Lebrija con el fin de conocer los aspectos que inciden en la seguridad alimentaria, que sirva de referencia para los entes de control, para lo cual se utilizó un estudio observacional de tipo descriptivo de corte transversal. Los resultados sugieren que la población de la vereda Uribe Uribe se encuentran en inseguridad alimentaria, la mayor incidencia se presenta en el grado de inseguridad leve con un 75% en los hogares en los cuales hay menores de 18 años
ANÁLISIS DE LOS EFECTOS QUE PRODUCE LA PRESENCIA DEL CADMIO EN EL CULTIVO DE CACAO (theobroma cacao)
Authors: Alvarez Morales Elsa Leuvany , Guillin Llanos Ximena Minshely , Rodríguez Angulo Dominga Ernestina
Published: March 2023

Esta investigación hace referencia a un estudio de las diferentes investigaciones relacionadas con la presencia de cadmio en el cultivos cacao (theobroma cacao), desarrolladas en el Ecuador. (Bruce A., 2009), señala que el cadmio (Cd) es un metal pesado existente en el ambiente (suelo, aire y agua) que puede estar presente en diversos alimentos consumidos por el hombre acumulándose en el organismo a lo largo de la vida, pudiendo llegar a niveles tóxicos. Es por ello que su ingesta a niveles elevados se le considera como un riesgo para la salud. El cadmio presente en el suelo puede ser de origen geogénico, resultante del proceso de formación del suelo y la composición de la roca madre; o de origen antrópico por la incorporación en el suelo (voluntaria o involuntaria) como parte de la actividad humana (Romero,2008).

Según la (Organizaicón Mundial de la Salud OMS, 2020) el efecto nocivo que causa el cadmio en el ser humano, es en los riñones y en los sistemas óseo y respiratorio; además, está clasificado como carcinógeno para los seres humanos. Métodos utilizados en la investigación es el inductivo, deductivo, analítico y lógico. La fuente secundaria permitió la recopilación de los artículos científicos de diferentes autores. De acuerdo a los estudios realizados algunos atribuyen la presencia del cadmio en las         de cacao al uso de aguas contaminadas por actividades mineras ilegales.

La acumulación de metales pesados en suelos agrícolas es un riesgo y sus efectos negativos dependen de la concentración del metal y de las propiedades específicas del suelo. Se dice que el suelo agrícola está contaminado cuando su concentración total pasa de 1.4 mg/kg de Cd total según los Estándares de Calidad Ambiental, en función de los diferentes estudios realizado temas de análisis de esta investigación se ha demostrado que todas las zonas agrícolas no se encuentra presencia de cadmio en los cultivos y que se están investigados otros rastros de la presencia del cadmio en los productos agrícolas.
Composición química y cinética de degradación ruminal del ensilado de pasto elefante con inclusión de cáscara de maracuyá
Authors: Espinoza Italo F. , Barrera Alexandra E. , Vivas León PhD. Montenegro
Published: March 2023

Se evaluó los parámetros de composición química, degradación y cinética ruminal del ensilado de pasto elefante (Pennisetum purpureum) con inclusión  residuos de  cascara de maracuyá (Passiflora edulis). Se aplico un diseño de bloques completos al azar con cuatro tratamientos (T1:0%; T2:10%;  T3:20% ,k  30% T4:40%) de inclusión de residuos de maracuyá, tres bloques (bovinos con rumen fistulados)  y siete tiempos de incubación  ruminal (0, 3, 6, 12, 24, 48 y 72 horas).  Las diferencias entre medias de tratamientos se establecieron mediante la prueba de Tukey (p<0.05). Tras 30 días de almacenamientos se  aperturaron  los minisilos y fueron similares en materia seca (MS)  y diferentes  (p<0.05)  en materia orgánica (MO),  el T1 (81.73%) presentó  menor porcentaje que los T2, T3, T4 y T5( 85.32, 85.54, 84.57 y 82,02% correspondientemente ), la cenizas (Cen) T1(18.27%) fue mayor (p<0.05) a los  T1; T2; T3; T4 y T5  ( 14.86, 14.46, 15.43 y 17.987% en su orden), la proteína cruda (PC) el T1 (4.42%) fue  menor   (p<0.05), a mayor inclusión de  residuos de maracuyá  se incrementa  la PC en los T1; T2; T3; T4 y  T5  (5.693; 5.25; 5.58 y 5.59%)  y el extracto etereo (EE) el T5: (0.90%)  fue diferente (p<0.05)  con los   T1; T2; T3 y  T4 (1.10; 1.43, 1.18 y 0.92% en su orden). Los contenidos de FDN y FDA fue mayor el T1 con (79.19 y 50.83% respectivamente), sin embargo, con la mezcla de 10% de RM (76.65 y 48.87%), 20% de RM (76.81 y 47.49%%) y 30% de RM (74.98 y 45.74%) se redujeron los porcentajes de fibra detergente neutra y ácida  (FDN y FDA). El porcentaje de digestibilidad in situ  de la materia seca    fue similar  (p>0.05) a las 0, 3, 6 12, 48 y 72 horas de incubación ruminal con la  inclusión de residuos de maracuyá  en el  pasto elefante y aumenta la degradabilidad del ensilaje y la cinética de degradación es similar.
Viabilidad técnica De Vivienda Campesina Con Muros De Gaviones En Los Llanos Orientales De Colombia
Authors: Bolívar Julián S. , Solarte Alexander
Published: March 2023

El presente estudio está fundamentado en el estudio de la viabilidad técnica de un sistema constructivo, mediante la implementación de muros en gaviones aplicados a viviendas campesinas ubicadas en los llanos orientales de Colombia. Se realizó una propuesta arquitectónica de una vivienda que cumpla las necesidades básicas. A partir de esta propuesta se construyó un modelo numérico en elementos finitos que represente el comportamiento real de la vivienda sometida ante las solicitaciones. Las propiedades mecánicas de los muros en gaviones necesarias para la construcción del modelo numérico, se determinaron a partir de una recopilación de información del estado del arte sobre investigaciones de caracterización de las propiedades mecánicas de gaviones con materiales similares que se encuentren en la zona de estudio. Y finalmente se optó por un estudio económico de los costos de construcción de viviendas campesinas con la implementación de muros en gaviones en los llanos orientales.
Contexto de cadena: algodón (Gossypium hirsutum)
Authors: Garavito Arcos Heydi Carolina
Published: March 2023

En esta ficha de contexto se mencionan los aspectos importantes de la cadena de algodón enfocados a su marco productivo, regional, económico, comercio internacional, así como sus perspectivas y tendencias frente al mercado, dando a conocer su entorno de Ciencia y Tecnología e Innovación.
Contexto de cadena carne bovina
Authors: Jiménez Guzmán Ana María
Published: March 2023

En esta ficha de contexto se mencionan los aspectos importantes de la cadena de carne bovina enfocados a su marco productivo, regional, económico, comercio internacional, así como sus perspectivas y tendencias frente al mercado, dando a conocer su entorno de Ciencia y Tecnología e Innovación.