bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of the CMA-GFS-AERO 4D-Var assimilation system v1.0 – Part 1: System description
Authors: Liu Yongzhu , Zhang Xiaoye , Han Wei , Wang Chao , Jia Wenxing , Wang Deying , Zhuang Zhaorong , Shen Xueshun
Published: November 2024

Abstract. We developed a strongly coupled chemistry meteorology four-dimensional variational (4D-Var) assimilation system, CMA-GFS-AERO 4D-Var, for investigating the feedbacks of chemical data assimilation on meteorological forecasts. This system was developed on the basis of the framework of the incremental analysis scheme of the China Meteorological Administration Global Forecasting System (CMA-GFS). CMA-GFS-AERO 4D-Var includes three component models: forward, tangent linear, and adjoint models. CMA-GFS-AERO forward model was constructed by integrating an aerosol module containing main physical processes of black carbon (BC) aerosol in the atmosphere into the CMA-GFS weather model. The tangent linear and the adjoint of the aerosol module was further developed and coupled online with the CMA-GFS tangent linear and adjoint models, respectively. In CMA-GFS-AERO 4D-Var, the BC mass concentration was used as the control variable and minimized together with atmospheric variables. The validation of this system includes the tangent linear approximation, the adjoint correctness test, the single-point observation ideal experiment and the full observation experiment. The results show that CMA-GFS-AERO tangent linear model performs well in tangent linear approximation for BC, and adjoint sensitivity agrees well with tangent linear sensitivity. Assimilating BC observations can generate analysis increments not only for BC but also for atmospheric variables, highlighting the capability of CMA-GFS-AERO 4D-Var in exploring the feedback effect of BC assimilation on atmospheric variables. The computational performance of CMA-GFS-AERO 4D-Var also indicates the potential in operational application. This study focuses on the theoretical architecture and practical implementation of the system, the detailed analysis of the batch test will be described in part 2 of this paper.
Impact of Mobile Applications on Tourism Development in Uzbekistan
Authors: Karimov Nodir , Kalandarova Mekhribon , Makhkamova Nodira , Asrorova Zukhra , Saydamatov Farkhod , Ablyakimova Refide , Karshiboeva Maftuna , Odilov Bobir
Published: November 2024

The rapid growth in mobile applications has completely transformed tourism globally, providing new tools and better opportunities to enhance experiences and accessibility for tourists. In Uzbekistan, with its great cultural heritage and historical sites, mobile applications can make a marked difference in the tourism sector by enhancing the engagement of tourists, improving the quality of services, and ensuring sustainability. The article explores the role of mobile applications in shaping the development of Uzbekistan's tourism industry by analysing how features like real-time information, booking services, and location-based recommendations make travelling smooth and personalised. It also discusses the challenges and opportunities regarding integrating mobile technologies into the country's tourist infrastructure, such as digital literacy, connectivity, and content issues. This present study, by case studies, end-user feedback, and industry data, points out the capacity of the mobile application to create more dynamic and accessible tourism in Uzbekistan for further economic development and increasing the country's attractiveness internationally.
КРИМИНАЛИСТИЧЕСКАЯ КЛАССИФИКАЦИЯ СПОСОБОВ МОШЕННИЧЕСТВА В СФЕРЕ БРАЧНО- СЕМЕЙНЫХ ОТНОШЕНИЙ
Authors: М.Е. КЛЮКОВА , И.О. АНТОНОВ , А.Ю. ВЕРИН
Published: November 2024

Рассматриваются способы мошенничества в сфере брачно-семейных отношений, которые яв- ляются ключевым элементом криминалистической характеристики данного вида преступлений. Проанализиро- ваны наиболее распространенные способы подготовки, совершения и сокрытия мошенничества в сфере брач- но-семейных отношений, а также типичные следы рассматриваемой разновидности криминального обмана. Показаны основные направления возможного использования знаний о содержании способов мошенничества в сфере брачно-семейных отношений в деятельности правоохранительных органов.

The article addresses an issue of the ways of fraud in matrimonial relations as a crucial element of criminalistic characteristics of given crime. The authors analyze the most common ways to plan, commit and conceal fraud within matrimonial relations as well as typical traces of criminal deception under study. The research reveals basic ways to apply data on ways of fraud committed within matrimonial relations to law enforcement process.
ПОСЛЕДСТВИЯ ВОЗРАЖЕНИЯ ГОСУДАРСТВЕННОГО ОБВИНИТЕЛЯ ПРИМЕНЕНИЮ ОСОБОГО ПОРЯДКА ПРИНЯТИЯ СУДЕБНОГО РЕШЕНИЯ ПРИ СОГЛАСИИ ОБВИНЯЕМОГО С ПРЕДЪЯВЛЕННЫМ ЕМУ ОБВИНЕНИЕМ
Authors: А.Г. ИБРАГИМОВ
Published: November 2024

Целью статьи является анализ последствий возражения государственного обвинителя в поста- новлении приговора без проведения судебного разбирательства при согласии обвиняемого с предъявленным ему обвинением.

The purpose of the article is to analyze the consequences of the objection of the state prosecutor to the sentencing without a trial, if the accused agrees with the charges brought against him.
ПЕРСПЕКТИВЫ РАЗВИТИЯ МАЛОГО И СРЕДНЕГО ПРЕДПРИНИМАТЕЛЬСТВА В УСЛОВИЯХ СПЕЦИАЛЬНОЙ ВОЕННОЙ ОПЕРАЦИИ
Authors: О.Н. ВАСИЛЬЕВА
Published: November 2024

Санкционное давление, усиление международной напряженности не могли не сказаться нега- тивно на развитии предпринимательства в Российской Федерации, однако число субъектов малого и среднего предпринимательства, несмотря на сложную геополитическую обстановку, с каждым годом лишь растёт. Бе- зусловно, данные проблемы не новы: беспрецедентное давление на российский бизнес оказывалось еще с 2014 года, при принятии странами Запада пакета санкций, повлиявшего на снижение инвестиций в российскую экономику и ограничение притока иностранного кредита. Следствием этого стал отток капитала из России, со- ставивший на тот момент 153 млрд долларов. Актуальность данной тематики обусловлена тем, что благоприят- ные условия для развития малого и среднего бизнеса и их рост способствуют ускорению экономического роста и стабильному развитию страны в целом в силу их влияния на экономику, а также в силу занимаемой ими доли.

Sanctions pressure and increased international tension could not but have a negative impact on the development of entrepreneurship in the Russian Federation, however, the number of small and medium-sized businesses, despite the difficult geopolitical situation, is growing every year. Of course, these problems are not new: unprecedented pressure on Russian business has been exerted since 2014, when Western countries adopted a package of sanctions that reduced investment in the Russian economy and restricted the inflow of foreign credit. The consequence of this was a capital outflow from Russia, totalling $153bn at the time. The relevance of this topic is due to the fact that favourable conditions for the development of small and medium-sized businesses and their growth contribute to the acceleration of economic growth and stable development of the country as a whole due to their impact on the economy, as well as due to the share they occupy.
ПРИНЦИПЫ ИНФОРМАЦИОННО-ПРАВОВОГО ОБЕСПЕЧЕНИЯ ЦИФРОВОЙ ЭКОНОМИКИ
Authors: П.А. РУСТАМОВ
Published: November 2024

Цель работы – переосмысление правовых конструкций и роли права в условиях цифровой эко- номики и разработка эффективных механизмов их регулирования. В статье применяются методы системного анализа, сравнительного правоведения и теоретического исследования. Рассматриваются актуальные вызовы, связанные с необходимостью адаптации правовой системы к быстроменяющимся условиям цифровизации, а также необходимость создания новых норм и стандартов для эффективного регулирования. Обсуждается роль государства как движущей силы изменений в контексте внедрения инновационных технологий и формирова- ния новой инфраструктуры для предоставления услуг. Выделены две основные позиции ученых-правоведов относительно принципов информационно-правового обеспечения цифровой экономики: одни исследователи выступают за использование существующих норм законодательства, тогда как другие считают этот подход не- достаточно обоснованным. Важность работы заключается в необходимости постоянного анализа и адаптации правовой системы к условиям цифровой экономики, что подчеркивает значимость нормативного регулирова- ния для устойчивого развития в данной сфере.

The purpose of the work is to rethink legal structures and the role of law in the digital economy and to develop effective mechanisms for their regulation. The article uses methods of system analysis, comparative law and theoretical research. The current challenges related to the need to adapt the legal system to the rapidly changing conditions of digitalization, as well as the need to create new norms and standards for effective regulation, are considered. The role of the state as a driving force of change in the context of the introduction of innovative technologies and the formation of a new infrastructure for the provision of services is discussed. There are two main positions among legal scholars regarding the principles of information and legal support for the digital economy: some researchers advocate the use of existing legislation, while others consider this approach insufficiently justified. The importance of the work lies in the need for constant analysis and adaptation of the legal system to the conditions of the digital economy, which emphasizes the importance of regulatory regulation for sustainable development in this area.
РЕЛИГИОЗНЫЕ ИСТОКИ ПРАВОВОЙ КУЛЬТУРЫ МОЛОДЕЖИ
Authors: М.Ф. КОСТЮК
Published: November 2024

статье религия рассматривается как мировоззрение, влияющее на поведение человека, ана- лизируются ее функции, причины возникновения и развития. Обосновывается вывод, что религиозные воззре- ния, составляющие духовную основу культурного кода человека, оказывают воздействие на правовую культу- ру. Это находит свое отражение в уголовном и гражданском законодательстве, иных отраслях права.

The article considers religion as a worldview that influences human behavior, analyzes its functions, causes of occurrence and development. The conclusion is substantiated that religious beliefs, which form the spiritual basis of a person's cultural code, have an impact on legal culture. This is reflected in criminal and civil legislation and other branches of law.
АДВОКАТУРА РЕСПУБЛИКИ БЕЛАРУСЬ: СОСТОЯНИЕ, ПРОБЛЕМЫ И ПУТИ РАЗВИТИЯ
Authors: М.В. ЖЕРДЕЦКИЙ
Published: November 2024

Цель работы – показать состояние института адвокатуры в Республике Беларусь, опираясь на анализ Закона «Об адвокатуре и адвокатской деятельности в Республике Беларусь» от 30 декабря 2011 г. (с изм. и доп.). При подготовке статьи использовались формально-юридический и сравнительно-правовой ме- тоды научного исследования. В статье исследуется процесс развития адвокатуры в Республике Беларусь, вно- сятся предложения по совершенствованию законодательства и оптимизации работы адвокатуры.

The purpose of the paper is to show the state of the institution of advocacy in the Republic of Belarus, based on the analysis of the Law «On Advocacy and Advocate profession in the Republic of Belarus» of 30 December 2011 (as amended). In preparing the article the formal-legal and comparative-legal methods of scientific research were used. The article examines the process of development of the Bar in the Republic of Belarus and makes proposals for improving the legislation and optimising the work of the Bar.
ИСПОЛЬЗОВАНИЕ СИСТЕМЫ ВЕБ-КОНФЕРЕНЦИИ ПРИ ИСПОЛНЕНИИ ИНОСТРАННЫХ СУДЕБНЫХ ПОРУЧЕНИЙ
Authors: Н.Н. КАРАНДАШЕВА
Published: November 2024

Цель работы – выявить возможности использования системы веб-конференции при исполне- нии иностранных судебных поручений. Авторы применяли общенаучные методы познания – анализ и синтез, а также частные методы правовой науки – формально-юридический, сравнительного правоведения. Отсутствие прямого регулирования национальным законодательством РФ процедуры использования си- стемы веб-конференции в судебном процессе по запросам иностранных судов привлекло внимание автора к возможности исполнения поручений о проведении видеосвязи в соответствии с Конвенцией о правовой по- мощи и правовых отношениях по гражданским, семейным и уголовным делам, подписанной в Кишинёве 7 октя- бря 2002 г., и Гаагской конвенцией о получении за границей доказательств по гражданским и торговым делам 1970 г., которые прямо или косвенно допускают использование видеосвязи для оказания правовой помощи между странами-участниками. На основе рекомендаций по интеграции информационных технологий в международный гражданский про- цесс, изложенных в Рекомендациях Гаагской конференции по передовому опыту использования видеосвязи, а также законодательных инициатив зарубежных стран в отношении упрощения проведения судебных заседаний с использованием видеоконференций для лиц, находящихся за пределами государства, автором предложено создание единой цифровой платформы для обмена судебными поручениями с применением системы видеос- вязи, что может повысить эффективность международного судебного сотрудничества.

The purpose of article is to identify the possibility of using the web-conference system in the execution of foreign letters of request. The following scientific methods were used in the study: scientific methods such as the analysis and synthesis, as well as special methods of legal science such as formal-legal, comparative law. The absence of direct regulation by the national legislation of the Russian Federation of the procedure of using the web-conference system in the court proceedings at the request of foreign courts attracted the author's attention to the possibility of executing video-link orders in accordance with the Convention on Legal Assistance and Legal Relations in Civil, Family and Criminal Matters, signed in Chisinau on 7 October 2002, and the Hague Convention on the Taking of Evidence Abroad in Civil and Commercial Matters, 1970, which directly or indirectly allow for the use of video-links in court proceedings. On the basis of recommendations on the integration of information technology in international civil proceedings, as set out in the Recommendations of the Hague Conference on Private International Law on best practices in the use of the video link, as well as legislative initiatives of foreign countries to simplify the conduct of court hearings using videoconferencing for persons outside the state, the author proposed the creation of a unified digital platform for the exchange of court letters of request using video link, which can increase the efficiency of international judicial proceedings.
In search of moral politics: Kant cosmopolitan right in state’s sovereignty crises
Authors: Martin Claudiu
Published: November 2024

Hay una tensión en la relación entre el derecho y la moralidad, especialmente en relación con el derecho cosmopolita. Por un lado, algunos comentaristas sostienen que hay una distinción marcada por la cual la moral debería subordinarse a la jurisdicción porque esta última pertenece a la esfera pública, mientras que la primera a la esfera privada, y por lo tanto la hospitalidad está vinculada al derecho. POr otro lado, algunos argumentan que la moral tiene prioridad al entender la hospitalidad como un ethos que es esencial para lograr la integración política y que va más allá de la esfera legal. Después de ver cómo Kant fundamenta los deberes, analizaré ambas perspectivas con respecto al derecho de hospitalidad. A continuación, se verá que para Kant el derecho y la moral son indistinguibles salvo por una excepción, a saber, cuando es el legislador quien no cumple con el derecho y no garantiza los tres principios básicos que sustentan una constitución civil: libertad, igualdad, independencia. Se argumentará que esta es una situación que se está dando actualmente, la soberanía del Estado ha entrado en crisis al producir legislación contraria a lo que Kant pensaba que serían los fundamentos legales porque, por una parte, el Estado no está sujeto a rendición de cuentas, y por otra, no se ha redefinido un derecho que tenga en consideración nuevas prácticas de libertad contemporáneas que están en armonía con la teorización kantiana. Se propondrán tres posibles soluciones a este problema basadas en el pensamiento de Kant. La primera es la desobediencia civil amparada por el criterio de publicidad. En segundo lugar, la cuestión ecológica como creadora de un estatus epistemológico que obliga a actuar de acuerdo con la voluntad general de la situación contemporánea. Finalmente, se propone la generosidad como una forma de acción política y un deber moral que tiene un carácter extensivo en la medida en que el sujeto se transforma a sí mismo y trasciende intereses, permitiéndole crear redes recíprocas y comunidades imprevistas que se ajustan al imperativo categórico e instituyen una forma de derecho basada en co-obligaciones.
Decifrar o enigma: o papel da filosofia em Kant e Schopenhauer
Authors: Gomez N. Pereira Rafael
Published: November 2024

O presente ensaio tem por objetivo analisar o papel da filosofia a partir da interlocução entre Immanuel Kant e Arthur Schopenhauer. Considerando a relação intelectual entre ambos, ensejamos percorrer a relevância e o papel do conhecimento filosófico em cada um dos autores, buscando pontos de aproximação e de afastamentos diante do papel que a filosofia deveria cumprir na ordenação do intelecto. Por parte de Kant, argumentamos sobre a filosofia como o caminho propedêutico para o controle da razão pura apresentando ao indivíduo os limites e as possibilidades do conhecimento racional. Por parte de Schopenhauer, nosso intuito foi o de sugerir que, para além da racionalidade, existiria uma instância metafísica marcada pela Vontade como algo irracional, sendo responsabilidade da filosofia a contemplação dessa mesma Vontade pela Ideia.
Recursos de Internet para traducir a Kant
Authors: Naragon Steve
Published: November 2024

Este artículo reúne varios recursos de Internet disponibles para traductores de textos de Kant, incluidos recursos para textos digitales de Kant y otros escritos históricamente relevantes, catálogos digitales de libros y publicaciones periódicas, diccionarios en línea y diccionarios monolingües y bilingües del siglo XVIII y XIX, enciclopedias y léxicos específicos de Kant disponibles digitalmente.
La recepción contemporánea y actual de las Lecciones y su traducción al español
Authors: Morán Roa Alberto , Méndez Castañeda Gonzalo
Published: November 2024

Más allá de las reticencias recibidas con respecto a su forma y contenido, las Lecciones —apuntes de los estudiantes de Immanuel Kant, en los que se recoge su docencia sobre diversas materias— son un valioso recurso para los estudios kantianos. Así lo corrobora el valor que les conferían sus contemporáneos, así como su papel en presentar la faceta docente de Kant, la evolución de su pensamiento, el modo en que se conceptualizan nociones filosóficas clave, y las tesis con las que enriquecen las ideas plasmadas en los textos escritos. Desde finales del siglo XX y, especialmente, a partir del XXI, varias de las Lecciones han sido traducidas al español, ofreciendo importantes recursos para la comunidad hispanohablante. En este artículo expondremos las aportaciones de estos libros de apuntes, tanto por los contemporáneos de Kant como en la actualidad, y desgranaremos las traducciones existentes al español, mencionando las decisiones de traducción de algunos conceptos clave, sus aportaciones más importantes, y su recepción académica.
Acerca del origen de la Crítica de la razón práctica. El contexto histórico-filosófico y su relevancia para la traducción de la obra.
Authors: Rivero Gabriel
Published: November 2024

El presente artículo investiga el origen de la Crítica de la razón práctica como obra independiente. En oposición a las interpretaciones que ven el origen de esta obra en el descubrimiento de la antinomia de la razón práctica o bien en el descubrimiento del “hecho” de la razón, el presente artículo sostiene la tesis de que la decisión de Kant se debe a un nuevo enfoque del uso y conocimiento práctico. Este nuevo enfoque se dirige, por un lado, a responder a críticas de naturaleza práctica y teórica que objetaban la existencia de la razón pura; por otro lado, a mostrar a la razón práctica como un “complemento” de la razón especulativa. A partir de la contextualización histórico-filosófica de la obra, se presentan en el último apartado del artículo algunas consideraciones respecto de la traducción del verbo “einsehen”.
Presentación: Temas y problemas de la edición y la traducción de los textos de Kant
Authors: Sánchez Rodríguez Manuel
Published: November 2024

Este monográfico de la revista Con-Textos Kantianos se centra en los diferentes temas y problemas que afectan a la edición y la traducción de los textos de Kant. La obra traducida que en cada caso se presenta al lector no solo está abierta a múltiples interpretaciones ulteriores, sino que es ella misma el resultado de un trabajo previo de documentación, estudio e interpretación que, por su propia naturaleza, exige multitud de decisiones. Los artículos aquí recogidos pertenecen a especialistas con experiencia en este ámbito específico de investigación y en ellos se exponen algunos de los fundamentos implicados en esta toma de decisiones.
Professional Development of a Teacher in the Context of Digitalization and Transformation of Education
Authors:   NPJSC «Abai Kazakh National Pedagogical University», ZHANBAYEVA Lyazzat , ABILDINA Ainur ,   JSC « Zhezkazgan University named after O.A. Baikonurov», SAGINTAEVA Saule ,   NPJSC «Abylkas Saginov Karaganda Technical University», ALIMBAEVA Zhibek ,   Nazarbayev University
Published: November 2024

The article discusses the conceptual directions of professional development of a modern teacher in the context of digitalization and transformation of education, in particular, the nominal form of professional development of the school staff «methodological subscription », as well as the tutor Network – a community of professionals with high professional skills who are passionate about their business, collegially solving topical issues of education and self-education for all subjects of the educational process. The main requirements for the development of digital skills of a teacher, filling existing professional deficits and the main contradictions in a modern school that inhibit the development of digital technologies in education are identified.The purpose of the scientific article was to determine the conceptual direction of professional development of a modern teacher in the context of digitalization and transformation of Education. In the course of the study, the following methods were used: analysis content, synthesis, comparative analysis.
GSTA1 gene polymorphisms are associated with cyclophosphamide effectiveness in lupus nephritis patients: A case-control study in Indonesia
Authors: Indrawijaya Yen YA. , Artarini Aluicia A. , Hamijoyo Laniyati , Iwo Maria I.
Published: November 2024

Glutathione-S-transferase alpha-1 (GSTA1) is an enzyme with high conjugation activity against aldophosphamide, a metabolite of cyclophosphamide and promoter polymorphisms in GSTA1 may influence the cyclophosphamide effectiveness. The aim of this study was to evaluate the effectiveness and side effects of cyclophosphamide in lupus nephritis patients, using GSTA1 variants as predictors. A case-control study was conducted at Hasan Sadikin Hospital, Bandung, Indonesia, involving 100 lupus nephritis patients from February 2023 to January 2024. The PCR-Sanger sequencing was used to genotype five selected single nucleotide polymorphisms (SNPs) in the GSTA1 promoter: -52 A>G, -69 T>C, -513 A>G, -567 G>T, and -631 G>T. The endpoint was assessed after six doses of cyclophosphamide by evaluating renal function, disease activity and side effects. Results indicated that six doses of intravenous cyclophosphamide treatment improved renal function and disease activity in the patients, as evidenced by significant changes in serum creatinine (0.79 vs 0.69 mg/dL), dipstick proteinuria (3.00 vs 1.50), creatinine clearance (98.50 vs 109.50 mL/min), and Modified Systemic Lupus Erythematosus Disease Activity Index 2000 (M-SLEDAI-2K) score (8.61 vs 6.95). The AG genotype at -513 A>G was associated with reduced cyclophosphamide effectiveness (odds ratio (OR): 0.19; 95%CI: 0.19–0.60; p=0.019). The GT genotype at -631 G>T independently increased the progression of anemia (OR: 2.41; 95%CI: 0.26–22.12; p=0.040). This study highlights that the presence of GSTA1 variants affected cyclophosphamide effectiveness in lupus nephritis patients, with heterozygous polymorphisms at -513 (AA to AG) and -631 (TT to GT) predicting reduced effectiveness of cyclophosphamide by enhancing GSTA1 promoter activity, while anemia further exacerbated lupus nephritis disease severity. GSTA1 polymorphism was not associated with the presence of alopecia, amenorrhea, gastrointestinal disorders, and leukopenia during cyclophosphamide therapy.
Neuroprotective and inflammatory biomarkers in pediatric drug-resistant epilepsy: Interplay between GDNF, IL-1β and vitamin D 25-OH
Authors: Saing Johannes H. , Sari Dina K. , Supriatmo Supriatmo , Fithrie Aida , Rusda Muhammad , Amin Mustafa M. , Pratama Muhammad A.
Published: November 2024

Drug-resistant epilepsy in pediatric patients is associated with neuroinflammation and neurodegeneration. Vitamin D 25-OH exerts neuroprotective effects, while glial cell line-derived neurotrophic factor (GDNF) and the proinflammatory cytokine interleukin-1β (IL-1β) are implicated in the mechanisms of neuroinflammation and epileptogenesis. The aim of this study was to investigate the relationship between vitamin D 25-OH, IL-1β, and GDNF levels with seizure severity and frequency in children with drug-resistant epilepsy. A cross-sectional study was conducted at Adam Malik Hospital, Medan, Indonesia, among children with drug-resistant epilepsy. Vitamin D 25-OH, IL-1β and GDNF levels were measured using enzyme-linked immunosorbent assay (ELISA). Epilepsy severity was assessed using the Hague Seizure Severity Scale (HASS), while seizure frequency was assessed using the Global Assessment of Severity of Epilepsy (GASE). The present study identified a significant correlation between GDNF levels and epilepsy severity, as measured by the HASS score (r=0.318; p=0.006). However, no significant correlation was observed between vitamin D 25-OH or IL-1β levels and epilepsy severity or seizure frequency (p>0.05). IL-1β levels correlated significantly with GDNF levels (r=0.525; p=0.001), but IL-1β did not directly correlate with seizure frequency or epilepsy severity. In conclusion, GDNF levels significantly correlated with epilepsy severity, suggesting that GDNF may serve as a potential biomarker for assessing epilepsy severity. However, further studies investigating the role of GDNF as a potential neurotrophic factor in the pathophysiology of epilepsy and its possible application as a therapeutic target are important.
Use Of Passiflora Incarnata L. Herba In The Treatment Of Cocaine Use Disorders: The Experience Of An Addiction Center In Monza, Italy.
Authors:   Dipartimento Salute Mentale e Dipendenze SERT - Monza, ASST Brianza (MB), Italy., Crespi Giovanna , Moretti Federica ,   Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Giampieri Emanuela ,   Doctor specialising in psychiatry and health statistics, Monza (MB) Iyaly., Galimberti Giovanni Luca ,   Dipartimento Salute Mentale e Dipendenze SERT - Monza, ASST Brianza (MB), Italy., Zanalda Enrico ,   DISM ASL TO3 &AOU San Luigi Gonzaga, Collegno (TO), Italy.
Published: November 2024

The authors report a real-world experience on the treatment of cocaine use disorders (craving) in outpatient treatment subjects at the addiction centre in Monza (MB, Italy). 38 patients with Substance Use Disorder (Cocaine) were enrolled over one year for substance craving treatment with Passiflora Incarnata L Herba at a dose of 600 mg/day for a period of two months.
Carbonic anhydrase, water dissociation and physiology of Kidney.
Authors:   Human Photosynthesis© Research Centre. Aguascalientes 2000, México., Herrera Arturo Solis
Published: November 2024

Carbonic anhydrase (CA) is a zinc metalloenzyme widely distributed throughout the tissues of the body. In the kidney, this enzyme is thought to play a pivotal role in urinary acidification and bicarbonate reabsorption. Two distinct isozymes of carbonic anhydrase have now been identified in the mammalian kidney. A soluble cytoplasmic form, similar if not identical to human erythrocyte carbonic anhydrase C, accounts for the bulk of the renal carbonic anhydrase activity.
A Note on the Suffix -i in Colloquial Spanish: Iconic Motivation, Distribution and Values
Authors:   Universitat de València, Martinez Paricio Violeta
Published: November 2024

he Diccionario de afijos del español contemporáneo (Fábregas 2023) reports the presence of an unstressed suffix -i, “of uncertain origin, possibly sound symbolic”, in Spanish. Fábregas notes that this suffix is primarily found in noun hypocoristics (e.g. Paqui, Juani, Pedri) but it also attaches to other categories, including adjectives (e.g. cuqui ‘cute’) and terms of address (e.g. mami ‘mummy’, cari ‘dear’). This article has three main goals. Firstly, building on previous studies as well as an examination of additional colloquial Spanish data, I aim to describe the specific distribution of the suffix, exploring whether there are other bases to which it may attach. Secondly, I examine the main semantic and pragmatic values of the affix, noting its productivity in colloquial Spanish, particularly among certain groups of speakers. Finally, building upon traditional and more recent works on sound symbolism, and drawing from the enactive theory of language, I discuss why the suffix -i may be said to have acquired iconic meanings among Spanish-speakers.
Languaging in Multimodal Digital Interaction: An Enactive Exploration of Emoji Metaphors and Meanings
Authors:   Universitat Jaume I (Castellón de la Plana, Espagne), Agnese Sampietro Agnese
Published: November 2024

Emojis, small pictographic characters commonly used in electronic messages, have become a global phenomenon. This study utilizes key enactive concepts to demonstrate how emojis reflect the ongoing interplay between technology, language, and culture. A central theme of the analysis is the role of metaphors in justifying the design, use, and interpretation of emojis, illustrating how these symbols originate, evolve, and adapt to the contextual nuances of our environment. The ultimate goal of this study is to enhance our understanding of the evolving meanings of emojis, emphasizing their dynamic nature, and enriching our understanding of their role and interpretation in contemporary human expression and interaction. In this context, emojis emerge as cultural artifacts that are both shaped by and continually shape how we communicate and interact in the digital age.
Non-Oil Sector Performance and Economic Growth in Nigeria
Authors: J. N. Ozoh, , C. M. Madueke, , N. F. Ezenwobi, , N. I. Onwuka, , A. O. Ezeife,
Published: November 2024

Most of Nigeria's public income comes from oil exports, making it vulnerable to global market crashes and instability. The economy is currently experiencing a downturn due to the 2014–2015 decline in the value of crude oil. To increase the manufacturing of non-oil product exports and generate external cash, the state government is nowadays met with the challenge of reorienting the economy to the non-oil sector. The study specifically considered the effect of non-oil sector performance, such as the output of the industrial, service, and agricultural sectors, on economic growth in Nigeria using yearly time series data from 1999 to 2022. The growth rate maximization theory was used in this investigation. The World Bank (2022) and the CBN Statistical Bulletin (2022) provided the data used in this analysis. Multiple regression analysis approaches were employed in the study. As the outcomes showed, the growth of the Nigerian economy is positively and significantly impacted by the output of the exchange rate, the manufacturing, service, and agricultural sectors; government spending has a negligible and negative effect on the growth of the economy. The research suggested that incentives should be created to support and expand Nigeria's manufacturing, service, and agricultural sectors to sustain the growth of the economy.
Leyla ve Mecnun Mesnevisinin Türk Sinemasında Temsili
Authors: Uğur İlkay , Toplu Mehmet
Published: November 2024

Halk hikayeleri, insanlığın ortak mirası olarak geçmişten günümüze kadar farklı anlatı biçimlerinde kuşaktan kuşağa aktarılmış anonim eserlerdir. İnsanların deneyimlerini, korkularını, mutluluklarını, savaşlarını, kahramanlıklarını anlatan bu hikayelerde aşka da yer verilmiştir. Halk hikayelerinde aşk, çeşitli engellerle kavuşamayan kadın ve erkeklerin maceralarında dile getirilmiştir. İki tarafında aşıklık sıfatını paylaştığı, iki kahramanlı, karşılıklı aşk hikayeleri, farklı biçimlerde yazılmış ama en çok kafiyeli, ikili mısralardan oluşan mesnevi tarzında olanlar dikkat çekmiştir. Leyla ve Mecnun’un hikayesi, en bilinen aşk hikayelerinden biridir. Arap edebiyatından kaynağını alan hikâye, Fars ve Türk edebiyatları başta olmak üzere tüm dünyaya yayılmış; her toplumun kendi yerel kültürüne göre biçimlenmiş, ama özü aynı kalmıştır. Mesnevi şeklinde ilk defa Nizami-i Gencevi tarafından Farsça yazılan hikâye, Türk edebiyatında da ilk kez Gülşehri tarafından konu olmuştur. Daha sonra birçok edebiyatçının eserlerine konu ederek ya da doğrudan aktardığı Leyla ve Mecnun’un aşkı, en güzel ifadesini 16. yüzyılda Fuzuli’nin mesnevisinde bulmuştur. Günümüzün çağdaş eserlerinde de yer almaya devam eden hikâye, sanatın farklı formları aracılığıyla da yansıtılmış, ama özellikle geniş kitlelere ulaşan sinema ile görselleştirilmesi, kıssayı somutlaştırmıştır. Türk Sineması’nda popüler melodramlar içinde işlenen halk anlatısı, Leyla ve Mecnun Gibi (1963), Leyla ile Mecnun (1972), Leyla ile Mecnun (1982) adlı filmlerde ele alınmıştır. Türk Sineması’nın, toplumda yaşanan siyasal, ekonomik ve sosyal-kültürel ani değişikliklerle şekillenen farklı dönemlerinde yapılan bu filmleri, sinematografik ve anlatı özellikleri bakımından toplumsal bağlamdan etkilenerek biçimlenmiştir. Bu çalışmada, sinemada dramaturji analizi ile filmlerin ana hikâyeyi aktarırken ne yönde farklılaştırdıkları ve çekildikleri dönemin toplumsal bağlamıyla, birbirlerinden hangi özelliklerle ayrıldıkları incelenmiştir.
DIAGNOSIS OF THE ALVEOLAR BONE CONDITION IN CASES OF TEETH WITH ANTERIOR CROSS BITE
Authors:   Department of Periodontology, Faculty of Dental Medicine, Medical University, Plovdiv, Bulgaria., Krasteva Stilyana , Krasteva Anzhelina ,   Department of Orthodontics, Faculty of Dental Medicine, Medical University, Plovdiv, Bulgaria., Krasteva Silviya ,   Department of Orthodontics, Faculty of Dental Medicine, Medical University, Plovdiv, Bulgaria., Yanev Nikolay ,   Department of Medical and Clinical-Diagnostic Activities, University of Ruse, Bulgaria.
Published: November 2024

Anterior cross bite is an occlusal etiological factor for the occurrence of gingival recession and resorption of the alveolar bone. Aim: To examine the condition of the alveolar bone in relation to incisor inclination in subjects with anterior cross bite. Materials and methods: Sixty one eligible subjects, with a mean age of 25.66±10.51 years, presented with anterior cross bite of a single teeth or a group of teeth. The distribution of patients by sex is women-42.6% and men-57.4%. The inclination of the upper and lower incisors was evaluated and analysed with Steiner C method. The bone resorption in the two jaws (distance from the enamel-cement junction of the incisors up to the beginning of the alveolar bone) was measured up to 0.01 mm. Results: Protrusions constituted a higher percentage than retrusion in both jaws. The mean value of bone resorption in the maxilla of subjects with retrusion was 4.01mm, whereas in subjects with protrusion, it was 3.42mm (p = 0.062). The mean value of bone resorption in the mandible of subjects with retrusion was 4.56mm, whereas in subjects with protrusion, it was 4.36mm. The bone resorption mean of the patients with retrusion in the mandible was 0.55mm higher than the mean of the patients with retrusion in the maxilla with high statistical significance (p = 0.008). Conclusion: Higher levels of bone resorption were observed in the mandible as compared to the maxilla. A significant linear relationship was found between the inclination of the incisors and the degree of bone resorption.
ANALYSIS OF METHODS FOR DISTANCE ESTIMATION TO AN OBJECT
FROM A SINGLE VIDEO CAMERA IMAGE USING NEURAL NETWORKS
Authors: LUPENKO N. , BOHUSH R. , CHEN H.
Published: November 2024

This paper discusses about any approaches to determining the distance to an object based on an image generated
by a monocular video camera, which use artificial neural networks at various stages of processing. Method
based on finding a depth map, detecting an object, and then projecting its coordinates onto the depth map is analyzed.
It describes a method that uses the relationship between the real size of an object and its size in the image. It considers
a method based on a modification of the YOLO, which allows expanding the resulting descriptor with an additional
vector characterizing the distance to the object. Data sets used to train neural networks used in algorithms for calculating
the absolute distance to an object based on an image is analyzed. The paper discusses about the effectiveness
of the methods considered, their advantages and disadvantages, as well as the prospects for using them
for practical solutions.
STRENGTH PROPERTIES OF DIAZOQUINONE PHOTORESIST FP9120 FILMS
ON MONOCRYSTALLINE SILICON IMPLANTED WITH ANTIMONY IONS
Authors: VABISHCHEVICH S. , VABISHCHEVICH N. , BRINKEVICH D. , PROSOLOVICH V.
Published: November 2024

The modification of the strength properties of films implanted with Sb+ ions of diazoquinone-novolac photoresist
FP9120 on monocrystalline silicon during long-term storage was investigated by the indentation method.
The dependence of microhardness on the load after implantation was nonmonotonic, due to the presence of elastic
stresses at the photoresist/silicon interface. During long-term storage, their relaxation was observed, which leads
to the disappearance of the non-monotonicity of the microhardness dependences on the load. The crosslinking
of phenol-formaldehyde resin molecules during long-term storage was also noted. This process was stimulated
by the decomposition of diazoquinone during ion implantation. During storage, the implanted photoresistive film
becomes less susceptible to elastoplastic recovery after the load is removed.
APPLICATION OF AMPLITUDE-FREQUENCY-MODULATED SIGNALS
FOR HYDROCARBON SEARCH
Authors: YANUSHKEVICH V.
Published: November 2024

The phase characteristics of the surface impedance of the medium above hydrocarbon deposits were studied
in the mode of their interaction with amplitude-frequency-modulated signals. The characteristics of the geological
profile above oil and gas deposits were investigated depending on the carrier frequency, modulating frequency
and modulation index. The rationale for using sounding with amplitude-frequency-modulated signals for practical
implementation in order to increase the information content and accuracy of determining hydrocarbon boundaries
was provided. A method for geoelectric exploration was developed to determine hydrocarbon boundaries using
amplitude-frequency-modulated signals based on measuring the phase characteristics of the surface impedance
of the medium above the deposits. The results obtained can be used for exploration geophysics in order to detect
oil and gas deposits.
ON THE PROPERTY OF UNIFORM COMPLETE CONTROLLABILITY
FOR A LINEAR SYSTEM WITH LOCAL INTEGRABLE COEFFICIENTS
Authors: KOZLOV A.
Published: November 2024

In this paper, the property of uniform complete controllability for linear systems with locally integrable
and integral coefficients is introduced (definition 3). The presence of the studied property in such systems allows
solving problems of both local and global control of their asymptotic characteristics, i. e. control of the asymptotics
of solutions of these dynamic systems (for more details, see the monograph [3]). The latter fact confirms
the relevance of the present research.
The family farms in the United States: social relations, scale and region
Authors: Mooney Patrick , Tanaka Keiko
Published: November 2024

Family farms are one of America’s cultural icons and an important element ofAmerican farming tradition. However, their definition is neither clear-cut nor unambiguous; asindicated by the authors of this article, the role and significance of family farms are differentfor all currently used definitions. Comparing and contemplating the definitions specified bythe USDA and UN-FAO, as well as the concepts put forth by American organizations, e. g. theNational Family Farm Coalition or Family Farm Defenders, the authors point out sizabledifferences in numbers and basic characteristics of family farms. These differences result fromfactors related to scale of production, extent of land ownership and tenancy, as well as varioussocial and regional influences. The two latter categories encompass issues affecting mid-sizedfarms (agriculture of the middle), the significance of income from extra-agricultural labor forthe family farm budget, the role and importance of hired labor, and the characteristics andextent of land tenancy. The authors stress the importance of family farming in maintaining thevitality of local communities and food security in the US along with its role in protectingbiodiversity and the environment. The closing part of the article focuses on addressing USrural policy, which should count protecting family farms among its key goals.
Rolnictwo rodzinne a świat w przyszłości
Authors: Michalska Sylwia
Published: November 2024

Jean-Michel Sourisseau (red.), 2014: Agricultures familiales et mondes a venire. Editions Quae, 360 stron
Enhancing crisis communication and risk management competencies: A qualitative study of city information officers
Authors:   San Pablo City Local Government Unit, Galicia Enrico , Aquino John Matthew ,   Pamantasan ng Lungsod ng San Pablo
Published: November 2024

This qualitative study examines the risk management, communication, and crisis response competencies of city information officers in San Pablo City, Philippines local government, focusing on how these officers effectively handle emergencies and manage public communication. Through semi-structured interviews with 15 regular staff members and 5 job-order workers, the study provides in-depth insights into their strengths and areas for improvement in crisis management. Thematic analysis of the interview data revealed that, while officers face certain challenges, such as occasional communication delays and limited formal training in risk management, they have demonstrated resilience and adaptability in high-pressure situations. Participants shared successful strategies they have employed, such as leveraging existing networks and utilizing local knowledge to ensure timely information dissemination during emergencies. Additionally, strong teamwork and interdepartmental collaboration were noted as strengths, enabling more efficient crisis response. The study highlights opportunities for further enhancing these competencies through targeted professional development programs in risk management and crisis communication. The findings suggest that, with the right support and training, city information officers can continue to improve their effectiveness in managing public communication during emergencies, ensuring better coordination and quicker responses to crises. This research provides practical recommendations for local government units to capitalize on existing strengths while addressing training gaps to further bolster their crisis management capabilities.
Revitalizing rural areas by boosting educational advancement through social capital integration
Authors:   University of KwaZulu-Natal, Moloi Marole Nkosikhona , Dlomo Sibongamandla Silindokuhle ,   University of KwaZulu-Natal
Published: November 2024

Community development in rural areas is crucial for enhancing educational quality by addressing the diverse needs of students, families, and the broader community. This study investigates how leveraging social capital can significantly improve educational outcomes in rural communities. The primary objective of this study is to explore how community development initiatives, underpinned by social capital, contribute to educational advancements by integrating essential services such as healthcare, social welfare, after-school programs, and parental involvement directly within the educational framework. The study employs a systematic review methodology guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework. This approach involves a comprehensive literature review to identify and analyze relevant studies. PRISMA guidelines were followed to ensure a rigorous and transparent reporting process, enhancing the reliability and validity of the findings in this study. The findings reveal the transformative impact of social capital on educational quality. Initiatives that effectively mobilize social networks and relationships lead to improved academic performance, social development, and emotional well-being of students. The study reveals the significance of stakeholder collaboration, supportive policies, and innovative pedagogies in sustaining and scaling these community-driven efforts. It is recommended by this study to strengthen stakeholder engagement, advocate for supportive policies, and integrate innovative teaching methods that will sustain and expand educational advancements. This study offers valuable insights into how social capital can address educational disparities and promote sustainable development in rural communities.
Empty sella and reversible central adrenal insufficiency in treated primary hypothyroidism
Authors: MS Al-Qudheeby Marwa , Al-Tarrah Hasan Ali , Al Azmi Fayez , Mehraj Shaikh
Published: November 2024

Introduction: Primary hypothyroidism can be complicated by pituitary-related sequelae. Along with a few other reports, we documented pituitary dysfunction with empty sella in primary hypothyroidism; however, the spontaneous reversibility of the hypopituitarism is rarely reported. We aimed to describe a rare complication of primary hypothyroidism and to emphasize the importance of monitoring such complications.

Case Report: We report a previously healthy 59-year-old man who presented four years earlier with weight gain of several months duration. The investigations revealed primary hypothyroidism with thyroxine 5.2 pmol/L (7.8–16) and thyroid stimulating hormone >100 uIU/L (0.27–4.2). He responded well to the thyroxine replacement as he became asymptomatic with normalization of thyroid stimulating hormone (TSH). After a few years, the patient presented with lethargy and postural hypotension despite euthyroidism. The basal and stimulated cortisol levels were low 73 (185–624) and 185 nmol/L respectively, while the adrenocorticotrophic hormone was inappropriately normal at 16.1 pg/mL (10.00–46.00). All the other pituitary hormones were normal. Magnetic resonance imaging showed partial empty sella. The patient preferred conservative management. Subsequently, he showed progressive clinical and hormonal improvement. As scarcely reported in the literature, primary hypothyroidism can be complicated by the development of empty sella, which can further develop pituitary endocrinopathies. Central adrenal insufficiency has been reported more often than other empty sella-related pituitary endocrinopathies, which might need long-term therapy.

Conclusion: We documented that empty sella and the associated hypopituitarism might complicate the primary hypothyroidism. This report encourages monitoring, and managing these complications in longer-term follow-up.