bluuebunny/crossref_metadata_2025 huggingface dataset:
Del cuerpo digital al cuerpo posthumano. La imagen corporal en la era digital, en la generación virtual y en el concepto posthumano
Authors: Villamarín-Fernández Elena
Published: April 2023

Somos conscientes de los cambios que ha experimentado la imagen corporal desde el comienzo de la era digital, pasando por la generación virtual, hasta llegar al concepto del cuerpo posthumano. El objetivo es reflexionar sobre cómo la evolución en la percepción del cuerpo se relaciona con el cambio de mentalidad que las nuevas tecnologías están produciendo en el individuo y en la sociedad. Desde una selección bibliográfica y desde una experiencia propia, se valora cómo percibimos nuestro cuerpo desde los ámbitos físico, social y cultural, también cómo se manipula la imagen corporal de manera tecnológica ocasionando en el individuo un temperamento egocéntrico y lúdico. Como resultado, al aceptar la ficción de nuestro cuerpo, permitimos que nuestra identidad se diluya. Bauman habla de la “sociedad líquida” en la que vive el individuo actual inmerso en un proceso de transformación constante. En conclusión, el desarrollo de las nuevas tecnologías seguirá moldeando la imagen de nuestro cuerpo y la mentalidad de nuestras sociedades futuras, siempre que el individuo sigua sintiendo atracción por estos avances. Parece inevitable que el concepto posthumano termine siendo radicalizado por movimientos que amparan el traspaso de los límites biológicos del cuerpo.
Towards a Genre Analysis of Online Book Discussion: socializing, participation and publication in the Dutch booksphere
Authors: Boot Peter
Published: April 2023

Books and writers are an important subject for discussion on many web sites. Book discussion on the web is a field considerably wider than the book blogs and the online reviews on booksellers sites that it is often identified with. It runs the whole spectrum from professional reviewers, through pro-am and traditional amateurs to occasional commentators. Book discussion takes place on sites as diverse as newspaper sites, online magazines, individual and group blogs, general and specialized social network sites, on traditional discussion boards and book cataloguing sites. This exploratory paper attempts a genre analysis of the Dutch booksphere, the collection of book-related sites on the web. It distinguishes between (i) site genres, which are high-level and necessarily fuzzy concepts, and a number of site facets for more precise site account, between (ii) genre of site and genre of information items on sites, and between (iii) genre of site and of sub-site. These distinctions create the conceptual apparatus for an account of the book discussion landscape and the various sites affordances.
A Multimodal Critical Discourse Analysis of Race, Class, Gender, and Sexual Orientation in the "It Gets Better Project"
Authors: Phillips Laurie
Published: April 2023

In September 2010, Dan Savage founded the YouTube-based “It Gets Better Project.” A key component within the ongoing social movement to eradicate youth bullying and suicide, IGBP messaging requires further examination of how life “gets better.” Through a Multimodal Critical Discourse Analysis and application of Collins’ (2000) matrix of domination framework, this study examines race, class, gender, and sexual orientation. Empirical data reveal participants offered little about their own racial and class identities and the impact of those on life getting better but were forthcoming in discussing how their gender and sexual identities impacted their childhood victimization. Concurrently, participants made gross assumptions about viewers’ racial, class, gender, and sexual identities, projecting an overly simplistic message of life improving regardless of viewers’ circumstances or intersectionality. Findings contribute to online participation research concerning how the internet is used for social change and how social inequalities are (re)produced in online projects.
The neohumanist moment and our planetary futures
Authors: Bussey Marcus
Published: April 2023

Neohumanism and global processes are described in this paper through the lens of the course on Global Citizenship taught by the author. The relationship between humanism is explored and the ongoing human project of becoming ‘global citizens’ is framed as one of expanded consciousness involving critical spirituality. Neohumanism is described as the product of intercultural dialogue. Just as Humanism has declared there is only one human family, Neohumanism declares there is only one planetary family. The current moment is one of crisis and opportunity. This is a Neohumanist moment that is at work ushering in one way of seeing the relational and spiritual possibilities of our planetary futures.
Investigating the Factors That Influence Digital Transformation: A Systematic Literature Review
Authors: Alshammari Khalid
Published: April 2023

The digital transformation is trending in the business world. All businesses are keen to have and pursue a digital transformation strategy. However, many organizations are not fully understood what digital transformation is, how it should be performed and what is the best for the organization. thus, this paper seeks to understand the factors that might impact the digital transformation in organizations.  This systematic literature review considers the course of digital transformation in organizations
Art, Music, & Mashups: A View from the Bench on Creativity and Copyright
Authors: McKeown M. Margaret
Published: April 2023

Creativity has captured human fascination for centuries. It has been said that “[t]here is little that shapes the human experience as profoundly and pervasively as creativity.” But what is creativity? Is it pure originality? Divine inspiration? Clever assimilation of existing ideas? Despite creativity’s central role in human progress, the term eludes finite definition.

To Plato, creative inspiration was divine. In contrast, Kant thought that creative geniuses were not divinely inspired but born with a particular quickness of mind that fostered brilliance and innovation. T.S. Eliot recognized the critical role of borrowing in creative work, quipping, “[i]mmature poets imitate; mature poets steal; bad poets deface what they take; and good poets make it into something better, or at least something different.”

In psychology, a leading theory of creativity requires inspiration from existing concepts. In his “associative theory” of creativity, Sarnoff Mednick posits that most of us have predictable, stereotypical associations with a given stimulus, while the creative among us are able to retrieve remote associations. For instance, although most associate “table” with “chair,” the creative might proffer “leg” or “food.” Defining creativity as a framework of novel associations between existing concepts, Mednick distinguishes originality from creativity, finding the former of little import.

However different theorists and disciplines might define creativity, its outcomes are varied, enduring, and ever evolving. Creativity has brought us everything from Rodin’s sculptures and Van Gogh’s paintings to Newton’s scientific discoveries, from musical scores and movies to computer code.

Where, then, does the law intersect with creativity? The United States Constitution directs Congress to “promote the Progress of Science and useful Arts, by securing for limited Times to Authors and Inventors the exclusive Right to their respective Writings and Discoveries.” Born from that critical clause is the American approach to copyright. Recognized by the U.S. Supreme Court as “the engine of free expression,” copyright law enriches “the general public through access to creative works.”

To illustrate how copyright law fulfills its aims through the lens of art, music, and “mashups,” I invite you to accompany me on a short tour of copyright law’s dance with creativity by offering select examples from federal appellate decisions and a view from the bench.
First Case Report of COVISHIELD Vaccine Induced Pityriasis Rosea-like Eruption Following Second Dose
Authors: Singla Ankur , Bansal Aditi , Kaur Sukhjot , Singh Aminder
Published: April 2023

COVISHIELD vaccine, approved in India for restricted use in emergency situation is a recombinant, replication-deficient chimpanzee adenovirus vector vaccine. Various cutaneous adverse effects post-covishield vaccine have been reported so far. We report the case of a 36-year-old female, who presented with an itchy skin rash of 3 days duration over the trunk and bilateral upper limbs. On examination, there were multiple, small, violaceous papules with adherent scales, coalescing to form small plaques over the abdomen, back, bilateral arms, and thighs. She had received second dose of the covishield vaccine 8 days prior to the onset of the skin rash. Skin biopsy revealed hyperkeratosis, parakeratosis, hypogranulosis, and spongiosis of the epidermis along with dermal lymphohistiocytic infiltrate, and mild interface dermatitis, consistent with pityriasis rosea-like eruption. She was managed with oral antihistamines and topical steroids. To the best of our knowledge, this is the first case of pityriasis rosea-like eruption following the second dose of the Covishield vaccine, reported from India.
Approach of Medical Students to Academic Research – The Futility of Crude Consequentialism
Authors: Mulkalwar Alhad
Published: April 2023

The means-ends debate lies at the very core of the subject of ethics. However, instead of adopting a dichotomous, black-and-white at-titude, it has been realized that one could pursue a goal oriented approach even without compromising on ethical standards. It would be prudent for students to inculcate such a balanced viewpoint in the formative years of medical education while pursuing their academic and co-curricular ambitions - being a part of research studies, for example. In order to extract the best of their experiences, students must not restrict their outlook to academic research merely as an addition to their résumés or just a task to be ticked off the to-do list. They should broaden their horizons and consider it as a privilege to be able to contribute to the profession and society even as young students of medicine.
Ensuring a Smooth and Hassle-Free Implementation of National Exit Test (NExT) exam: Feedback from a Pan-India online cross-sectional survey
Authors: Ingawale Sushrut , Suvvari Tarun Kumar , Anand Shubham , Garg Rakesh , Edara Lokesh
Published: April 2023

Background: The National Exit Test (NExT) exam is a proposed common entrance exam for both licensing to practice medicine and admission to postgraduate medical courses in India. Recently NMC published a draft for NExT Regulations to seek comments from the students, faculty and stakeholders. So, we aimed to assess the perception of MBBS students, graduates and medical faculty towards NExT Regulations to ensure a smooth and hassle-free implementation of NExT Exam. Materials and Methods: A cross-sectional questionnaire based study was conducted online during January 2023. The study question-naire included various types of questions: yes/no/maybe, single best response, likert scale and open ended questions pertaining to the specific points about the NExT draft. The questions were designed under the main domains of: (1) Participant characteristics, (2) General acceptance about NExT, (3) Feedback for NExT Step 1, and (4) Feedback for NExT Step 2. Results: Of the 1412 participants, 873 (61.8%) participants felt that there was ‘No Need’ to replace the conventional theory exam. 895 (64.4%) participants preferred to have a single paper exam. 1141 (80.8%) opined that there should be ‘Single best response type Multiple choice questions (MCQs)’ only. Of the 1412 participants, 559 (39.6%) opined that the score should be valid only for 1 year and 550 (39%) opined it to remain valid for 3 years. 1042 (73.8%) participants felt there was No need for NExT Step 2. Conclusion: Though the implementation of NExT was planned with an intention to elevate the quality of medical education and bring a certain degree of uniformity across the nation, the policy level thought process did not fully percolate to the masses, especially students. The reasoning for the changes is not strongly supported by previous year data in the proposed draft. Therefore, there is a need to allevi-ate the anxiety among students about the NExT exam before implementing it. Based on our study we were able to give our suggestion to the proposed NExT draft.
Blunt Cerebrovascular Injury with Delayed Ischemic Stroke - A Case Report with Discussion on Diagnosis and Management
Authors: Aravind Vidya , Jayalekshmi A  , K P Shaira
Published: April 2023

Blunt cerebrovascular injury(BCVI) can cause devastating morbidity and mortality. The problem with BCVI is that most physicians and health workers are not aware of this condition. It can present with periods of a varying time frame of about 12 to 36 hours or as late as 1 week after trauma. This may result in the complacent attitude of health workers that all is well given the initial normal finding in CT. This article aims at highlighting the importance of early diagnosis and treatment, to prevent and halt the progression of the injury into stroke and its resultant morbid consequences. This case report is that of a young male patient who came to the casualty with a history of assault and neck injury. He was hemodynamically stable and was managed with suturing of the wound. Initial imaging did not reveal any vessel injury, but he developed a stroke 36 hours later. A brief commentary on causes, presentation, early diagnosis, and management is described.
Role of Ketamine in Refractory Depression
Authors: Maithri Kolluri , Sandeep Podalakuru , Kumar Kota Suresh
Published: April 2023

Context: Refractory depression is seen in at least 10 to 30 percent of the patients suffering from depression. Ketamine is a new and effective option with rapid onset of action. But there are limited studies where IM Ketamine was used for treating refractory depression. Hence, this study is aimed at assessing the efficacy of IM Ketamine in patients with refractory depressionAims: To assess the efficacy of intramuscular Ketamine in adult patients with refractory depression.Settings and Design: This was study carried out at a tertiary care center. A total of 15 consecutive patients with refractory depres-sion were recruited. They were administered IM Ketamine (0.5 mg per kg body weight) and HAM D scores were recorded at baseline, after 4 hrs, 24hrs, 72 hrs, and 1 week.Methods and Material: This was an open-label prospective study. 15 subjects between the ages of 18 and 60 were evaluated to make a diagnosis of refractory depression and were recruited after obtaining informed consent. Following materials were used1. Semi-structured case record form2. Hamilton depression rating scale3. Inj. Ketamine 0.5 mg/kg. Statistical analysis used: Paired T-test and chi-square test were usedResults: Patients started improving with IM Ketamine within 4 hours, peak response attained within 48 hrs and lasted for 72 hrs. HAM D score deteriorated and reached the baseline after 1 week in almost all patients.Conclusions: IM administration of Ketamine is effective in refractory depression. It has a rapid onset of action, similar to the IV route.
Doctors and Law
Authors: Naidu T.K.K
Published: April 2023

Doctor in the court room is a traditional contribution of medicine to justice. With accelerating interchange of knowledge between law and medicine currently in progress, courts have noted a new decisive role played by the medical witness. Role of doctor as a legal administrator and social engineer is vital in a civilized society. People follow medicine, law follows people. Medical knowl-edge must be used effectively to provide truthful medical facts and opinions to settle adjudicate legal conflicts. The doctor must accept the responsibility of medical facts and opinion in the administration of justice.
Profile of Children suspected of ASD in a Tertiary Care Centre
Authors: Pratyusha Adi , Mandadi Gowri Devi
Published: April 2023

Introduction: Autism Spectrum Disorder (ASD) is a neurodevelopmental condition seen in children during their early develop-mental phase where children lack in achieving age-appropriate skills or they are unable to meet the social demands due to limited capacities. It is characterised by impairments in social communication, interaction and presence of restrictive, repetitive interests/behaviours. Prevalence of ASD has increased in recent times which warrants for early identification and intervention. *The word Autism is used in this study to denote Autism Spectrum Disorders. Aim: To study the profile of children less than 5yrs of age specifically brought for suspicion of ASD by parents. Methodology: This is a cross sectional descriptive study conducted at Child Psychiatry Department of Asha Hospital for 1year with children less than 5yrs of age. 44 children with suspicion of ASD, brought by parents were evaluated through clinical inter-view using DSM-5, psychological tests- Developmental screening test, CARS-2(Childhood Autism Rating Scale), M-CHAT and CBCL. Results: Most children were between 3-5yrs of age (68.18%), were predominantly males (72.73%), 47.73% had significant prena-tal factors, 22.73% of mothers had preterm delivery, 27.27% had postnatal complications, 36.36% of children had Delayed mile-stones and 59.09% speech delay. The symptoms presented were, ‘poor/no’ response to name (90.90%), poor Eye-Eye contact (95.46%), poor socialisation (97.73%), stereotypic behaviour (81.18%) and sensory issues (52.27%). ADHD (54.54%) & intel-lectual disability (95.45%) were the common psychiatric comorbidity.18.18% children had mild autism and 15.90% children were at a risk of autism. Conclusions: The symptoms presented by parents for suspicion of autism were depicted to be either mild or risk of ASD on screening
The Road to International Occupational Health & Hazards
Authors: Rao J Vijay
Published: April 2023

Occupational diseases are essentially preventable and can be ascribed to faulty working conditions. The control of occupational health hazards decreases the incidence of work-related diseases and accidents and to improve the health and morale of the work force, leading to decreased absenteeism and increased worker efficiency. In most cases the moral and economic benefits far outweigh the costs of eliminating occupational hazards.To sum up, occupational diseases are related to exposures to physical, chemical, biological, mechanical, psychological hazards at workplaces. They usually develop over a period of time and often resemble or duplicate diseases occurring due to natural cause. For these reasons, most occupational diseases are often overlooked or misdiagnosed and are undercounted in statistical reports. They are more common than is generally realized.Occupational Diseases are the one that receive step motherly treatment both by the industry and the medical profession. The reasons for their visible presence and glaring neglect are much known. In the process of developing tools to solve occupational health issues, not much has been done towards improving the medical management of Occupational diseases. The reasons are many. One of the main factors is that the occupational diseases are technology related. When new technology comes into practice, incidents of new work-related diseases increase. We build on these facts, by encouraging the promotion and exchange of ideas to generate new initiatives. Given the range of diseases and broad scope of industries involved, occupational health focuses on work that is aimed at tackling health issues by preventing them at the sources levels, then awaiting for diseases to occur.
Spontaneous Non-Traumatic Abdominal Wall Herniation of Liver
Authors: Mulkoju Ravindrachari , Leo Sneha , Janga Sneha Priya
Published: April 2023

A 55-year-old female presented with cough for the past two years and pain over right posterior lower chest wall for two months. An ill-defined 6 x 4 cm non-tender bulging over right infra-axillary area on the posterior axillary line was noted. The patient denied trauma/surgery to the chest or abdomen in the past. Upon evaluation with high-resolution computed tomography (HRCT) of the thorax and abdomen, bilateral diffuse cystic bronchiectasis along with thinning of posterior abdominal wall of approximately 7cm width with liver parenchyma herniation was noted. The mass was located above the superior lumbar triangle of Grynfelt. When the force of the cough is greater than the elastic limit of the ribs and thoracic and abdominal walls, a prolapse of the organs over the most vulnerable locations can occur. An unnecessary invasive procedure, such as thoracotomy and/or biopsy can thus be avoided based on clinical or radiological diagnosis.
Successful Pregnancy after Choriocarcinoma
Authors: Jaiswal Roma Rai , Jaiswal Malay
Published: April 2023

Choriocarcinoma is an aggressive malignant disease that originates in the trophoblastic cells of the placenta, characterized by early hematogenous spread to the lungs. It is a hyper vascular tumour composed of sheets of malignant cytotrophoblast and syncytio-trophoblast metastasizing hematogenously and producing a dramatic rise in b hCG levels. Here, we present a case of a female patient who conceived spontaneously after being diagnosed with Choriocarcinoma and undergoing chemotherapy in liaison with an Oncophysician. This case report shows that proper care and timely treatment can give a favourable outcome in a patient diag-nosed with Choriocarcinoma. Completion of chemotherapy will give desired favourable results with positive message as presented in the case below.
Mob Attack on Doctors
Authors: N Mallesh
Published: April 2023

Mob attacks on doctors have become common now a days. Almost every doctor is worried about their safety in workplace. Only few of us are trained to avoid or tackle the situation. There are many cases in which doctors were injured, beaten badly, harassed, murdered which we came across in social media. Doctors need to be alert and must know the warning signs of an attack. Violence against doctors can be prevented at several levels with the help of government, media, and educational institutions. We need to handle the situation timely to protect ourselves from such attacks.
Foreign research experience of the effect of probiotic agent on the intestinal microbiome of poultry
Authors: Pimenov N. V. , Smirnova E. , Ivannikova R. F.
Published: April 2023

The intensive development of industrial animal husbandry and poultry farming, along with the ban on the use of antibiotics for non-medicinal purposes, requires a revision of stimulating and therapeutic and preventive approaches aimed at increasing productivity, protecting against infections and improving other production parameters, such as feed digestibility and improving the efficiency of digestion, stimulating growth and development, the quality of meat, milk, eggs. In this regard, probiotic, prebiotic and synbiotic drugs and feed additives have become widespread. Funds based on antagonistic bacteria and representatives of symbiotic microflora are actively being introduced into poultry technology, a wide domestic research experience reveals their prospects. Used mainly to maintain the balance of the intestinal microbiota, they turn out to be an effective method of combating opportunistic pathogens.

At the same time, in the countries of developed industrial poultry farming, products based on probiotic cultures have not been widely used, and a number of sources are skeptical about the ability of probiotics to influence the intestinal microbiome of poultry. This article discusses various modern studies that carry the opinions of foreign authors about the effectiveness of probiotics and their effect on the intestinal microbiome of poultry.
Hygiene of Dog keeping
Authors: Belopolsky A. E.
Published: April 2023

The article provides data on the study of the norms and rules of keeping and feeding dogs in kennels and at home. Cynology as a science has developed in such a way that long before various scientific theories and justifications, there was practice and experience in breeding and keeping dogs. Over the centuries, hundreds of breeds adapted to his needs have been bred by man, and assessment methods and control standards for these breeds have been formed and developed in dog breeding communities. Breeding dogs is always inextricably linked with their full feeding, maintenance and care. So, a room intended for keeping dogs must meet basic hygiene requirements, not disrupt the normal course of life processes and not reduce its resistance to various diseases. Because with the wrong methods of growing, even from the most outstanding producers, it is impossible to get high-quality viable livestock.
Vascularization of the left heart of a German shepherd
Authors: Zelenevsky N. V. , Shchipakin M. V. , Melnikov S. I.
Published: April 2023

The variability of branching of the coronary arteries of the heart determines the dominance of one artery over the other in the left or right coronary types of blood supply. Thus, in the left coronary type, the right coronary artery is poorly developed and vascularizes a small area of the heart, or may be completely absent. The same phenomenon, respectively, can be observed in the right-handed type with the left coronary artery. The German Shepherd is a typical representative of the leftcoronary type of blood supply to the heart, like all other representatives of its species. The aim of our study is to study the vascularization of the left half of the German Shepherd heart. To study the vascular bed of the German Shepherd heart, ten corpses of dogs of this breed were obtained at the age of two to three years after forced euthanasia. The cadaveric material was delivered from private clinics in St. Petersburg to the Department of Animal Anatomy of the St. Petersburg State University of Veterinary Medicine. The vascular bed of the heart of a German Shepherd was investigated by applying such methods as fine anatomical preparation with filling the vascular bed with latex, as well as corrosion treatment of the obtained material. As a result of the study, it was found that the source of vascularization of the left half of the heart is the left coronary artery and its main arteries, including the paraconal, subsinus, circumferential, left interventricular and left diagonal arteries. The subsinusoid artery is a branch of the left coronary artery, while the right coronary artery does not reach the region of the subsinus sulcus. The interventricular septum of the heart in a German Shepherd is completely vascularized by branches of the left coronary artery. The main artery in this case is the left interventricular artery. The results obtained confirm that the presence of a left-coronary type of blood supply to the heart in an animal does not determine that the region of the subsinus sulcus will be vascularized by the branches of the right coronary artery.
Assessment of the impact of the use of Iodine- and Selenium-containing drugs on the biochemical status of cows in the biogeochemical province
Authors: Karpenko L. Yu. , Bakhta A. A. , Ivanova K. P.
Published: April 2023

Pskov and its region are biogeochemical provinces, since the composition of the soil of these territories is characterized by a low content of iodine and selenium. The deficiency of these trace elements will affect the composition of the feed, so it is necessary to use preparations based on selenium and iodine to prevent the appearance of symptoms of the corresponding microelementoses in cows kept in such areas. When evaluating the data obtained, a decrease in milking calcium and phosphorus in the blood serum of cows in the control group was revealed, which most likely occurred due to a lack of iodine and selenium in the normal diet of the natural cows of this farm. There is also a noticeable increase in such indicators as calcium and phosphorus in the selected samples of blood serum in both experimental groups of animals, in the diet of which two drugs were introduced: "Kayod" and "Sedimin". This haylage means a positive trend in the use of these preparations for animals.
Analysis of the Anthrax outbreak in the Akmola region of Kazakhstan
Authors: Sushchikh V. Yu. , Yusupov M. R. , Dyusenov C. M. , Kanatov B. , Karimov A. A.
Published: April 2023

Despite the ongoing preventive measures against anthrax, in Kazakhstan, as in other countries, this disease has not been eliminated. The system of supervision and control of anthrax provides for the identification of territories unfavorable for anthrax, the causes of animal diseases.

The purpose of the study is a retrospective analysis of the anthrax outbreak in the territory of Kazakhstan in the Akmola region in 2019 to identify the causes of the outbreak, and the expected risks of its occurrence in the future, to improve veterinary and sanitary measures.

Epizootological methods were used in the work, including a comparative historical and geographical description of anthrax outbreaks in the Akmola region.

During the investigation of the outbreak, it was found that the grazing of animals was carried out on different pastures. Infection of people occurred in the village of Olginka during the forced slaughter and cutting of two heads of cattle. According to the information, in the village of Olginka, in the first days of September 2019, a bull and a cow were slaughtered. The owners are residents of the village of Olginka. A few days after the slaughter of the animals, the villagers involved in the slaughter fell ill with anthrax.

When examining the landscape of the area, it was established that there are numerous colonies of rodent burrows throughout the pasture. According to local residents, a significant increase in the number of rodents was noted in 2019.

Presumably, the infection of animals on pastures occurred due to the activation of previously unidentified anthrax burials. The removal to the surface of deep layers of soil contaminated with anthrax spores due to the presence of numerous rodent burrows in the pasture. Employees of the committee of veterinary control and supervision of the region, as well as local veterinary specialists, are recommended to vaccinate farm animals twice a year.
The effectiveness of the use of mastitis vaccine in breeding farms
Authors: Isakova M. N. , Ryaposova M. V. , Sivkova U. V.
Published: April 2023

The article presents data showing the effectiveness of the use of anti-mastitis vaccine in breeding farms of the Sverdlovsk region, based on the study of the level of diagnosed mastitis and the indicator of somatic cells in milk. Studies have shown that the use of animal immunization against mastitis has a positive effect, so 6 months after the first vaccination of animals in the breeding reproducer and plant, the number of detected mastitis decreased by 16,6% and 7,3%, respectively, and the level of somatic cells in the milk of highly productive cows by 26,5% and 10,7%, respectively. 12 months after the first vaccination scheme was applied, the total number of animals with signs of mastitis in the breeding reproducer and plant was 13,3% and 7,5%, respectively. The level of somatic cells in the nucleus amounted to 290 thousand. /ml., and the stud farm of 450 thousand/ml 24 months after first use of vaccination schemes, the level of mastitis was identified at 6,0% and 5,7% of the studied population of high yielding cows breeding farm and breeding farm, respectively. The average number of somatic cells found in milk of animals of a farm decreased by 80 thousand/ml, the farm – to 79 thousand/ml, in comparison with the previous study period. The study revealed a significant decrease in diagnosed mastitis in animals after 32 months due to the use of the STARTVAK antimastitic vaccine, the total number of diseases in the breeding reproducer decreased by 30,6% compared to the period of the beginning of vaccination, and in the breeding plant – by 26,2%. As a result, the dynamics of reduction of subclinical and clinical mastitis in the breeder compared to the period at the time of immunization was 19,5% and 11,1%, respectively. And in the stud farm, the level of subclinical and clinical mastitis decreased by 16,9% and 9,0%, respectively. The number of somatic cells in the milk of cows contained in the breeding reproducer was 152 thousand/ml, which is 83,9% lower compared to the initial study period. The level of somatic cells in the studied samples of milk of animals kept in the breeding plant was 263 thousand/ml, which is 62,2% lower than this indicator before the application of the animal vaccination program against mastitis.
Comparative characteristics of various methods of treating babesiosis in dogs
Authors: Egorkina E. P. , Gaponova V. N.
Published: April 2023

Due to the wide spread of babesiosis in Russia, a seasonal disease caused by protozoan blood parasites from the genus Babesia, a limited number of drugs used in its treatment, this work is devoted to determining the effectiveness of 5% imidocarb solution ("Forticarb") and 12% imidocarb solution ("Pyro-stop") with babesiosis in dogs. According to the results of the study, it can be concluded that a higher therapeutic efficacy was observed when using a 5% imidocarb solution, which is due to a lower concentration of the active substance in comparison with the second group of animals. The lower concentration of the solution used was a deterrent factor in the rapid death of Babesia canis and, accordingly, in the development of side effects as a result of the formation of a huge number of toxic decay products of both the cells of one's own body and blood parasites. The use of concomitant therapy helped to minimize side effects, stimulate hematopoiesis, provided antiinflammatory, antiallergic, hepatoprotective effects.
The problem of validation of toxicological models in pharmacy
Authors: Popova O. S.
Published: April 2023

Animal toxicity testing is widely used in the chemical, pharmaceutical and research industries as a part of preclinical laboratory testing of substances to ensure that chemicals are safe for humans and animals. Under preclinical conditions, the safe and effective dose, acceptable dose, and exposure threshold of a substance can be established using mammals and rodents. There are enough materials on the introduction of biomodels in experiments. To summarize this knowledge, a polythematic abstract-bibliographic base was analyzed. The main attention was paid to such scientometric databases as: Web of Science Core Collection, Medline, PubMed, RSCI, as well as eLIBRARY.ru portal data for the last 10 years. An assessment of the statistical data and publication activity of the authors was made for the query modeling and ethics in veterinary medicine and medicine.

The aim of the study was to analyze modern models and prospects for using new biomodels for experiments in pharmacology and toxicology.

Having established protocols is important to ensure consistency between different studies within the same model, ensuring reproducibility and repeatability in experiments.

Based on the analysis of literature sources over the past 10 years, it can be concluded that despite the large number of regulatory framework and transgenic laboratory animals with embedded human target genes in their genome, it is not possible to obtain an identity. Probably, the main bias in predictive toxicology will be made on neural networks and computer replacement of existing biomodels. Since, despite their relative accuracy, maintenance and feeding are costly, and the field of using animals in experiments is increasingly criticized and requires new approaches.
Evaluation of the prospects for the use of Danio Rerio (Zebrafish) as biological model in the context of the study of hepatotoxic effects
Authors: Ponamarev V. S.
Published: April 2023

This article describes the morphological structure of the zebrafish liver and its comparison with the organization of the liver of mammals, known methods for inducing liver pathologies in these fish, and assesses the prospects for using Danio rerio (Zebrafish) as biological models in the context of studying hepatotoxic effects.

The scientific novelty of the publication lies in the complexity of the ongoing review of existing studies in the field of using model animals to assess various hepatotoxic effects, identifying the most promising approaches from the point of view of veterinary hepatology for their further possible introduction into industry practice.

The information retrieval methodology was based on such general scientific methods of cognition as: a review of specialized search engines and databases of scientific and research data (Scopus, WoS, PubMed) over the past 10 years, of which the most informative ones were selected, analysis of the identified results, their comparison by relevance.

Summing up the results of the search, we can conclude that the results of relevant experiments indicate the promise of studying hepatotoxic effects on zebrafish, which represent a promising and cost-effective alternative to other model objects. Danio rerio can reproduce in detail and with high accuracy the patterns of occurrence, development and outcome of pathological processes in mammalian organs due to the high level of genetic preservation and similar morphology and functions of organs. It is believed that further technical development and characterization of these biomodels in the context of the study of hepatotoxicity will provide new insights into the molecular and cellular mechanisms underlying disease pathogenesis, thereby providing multiple opportunities for the identification and validation of new therapeutic targets and treatments.
LA MANZANILLA Y SUS PROPIEDADES MEDICINALES
Authors: Gómez Ugarte Magaly , Reyes Rojas Shirley , Paredes Choque Laura
Published: April 2023

Para todo ser humano es indispensable conocer el fundamento de los productos naturales, los cuales pueden ser consumidos y aplicados en sus diferentes presentaciones, como infusiones, ungüentos y otros.

La manzanilla es una planta herbácea nativa y resistente a cambios climáticos con fácil adaptación geográfica. Uno de los problemas actuales en el área de la salud es la "automedicación" y el uso indiscriminado de medicamentos sin prescripción médica, que a futuro podrían desencadenar diversas patologías, así como en la resistencia a los antibióticos, por lo que recurrir al consumo de plantas naturales para el alivio de ciertas dolencias, son una buena alternativa.

Se realizó un estudio de tipo descriptivo, con el objetivo de determinar el principio activo de la manzanilla y las diferentes formas de preparación y/o posología para el consumo, que favorezcan al alivio de dolores estomacales, inflamaciones y otros, gracias a sus componentes como hidratos de carbono, mucílago, glucósidos flavónicos, ácidos grasos, vitamina C, ácidos orgánicos, alcoholes y pigmentos, que actúan como un eficaz calmante y desinflamante.
PROPIEDADES MEDICINALES DEL POMELO, BENEFICIOS NUTRICIONALES Y SU APLICACIÓN EN LA ESTETICA
Authors: Gómez Ugarte Magaly , Escalera Cruz David Angel , Peralta Mamani Lesly Eliana , Martinez Ayala Aleyda Abigail , Paredes Fernandez Dayana Lilian , Conde Camacho Yessica
Published: April 2023

El pomelo es un fruto cítrico del género de las rutáceas. El pomelo es muy adecuado en la prevención degeneración de las progresiva enfermedades del organismo, resultantes como de la degeneración macular o los problemas cardiovasculares.

Tradicionalmente se ha utilizado para combatir los resfriados y la gripe, disminuyendo los síntomas de la enfermedad y acelerando el proceso de recuperación. Ideal para todas las enfermedades del aparato respiratorio. Sin embargo, también favorece la digestión de los alimentos, sobre todo aquellos ricos en grasas. Posee propiedades que estimulan la producción de bilis en el hígado y su expulsión por parte de la vesícula biliar. El extracto de las semillas del pomelo se puede usar como antiséptico natural ya que impide el crecimiento de hongos, bacterias y virus.

Con el presente trabajo de investigación se pretende informar a la población en general de los beneficios del pomelo y recomendar en su utilización como una alternativa de la medicina natural.
EFECTO DE LOS CUELLOS DE BOTELLA GENÉTICOS EN LAS POBLACIONES ORIGINARIAS DE AMÉRICA
Authors: Taboada Lugo Noel , Lardoeyt Ferrer Roberto
Published: April 2023

América fue el último continente en ser poblado por humanos. Estas poblaciones originarias sufrieron severos cuellos de botella genéticos, durante los cuales el número de individuos decreció de forma notoria, posiblemente debido a los recursos limitados, a enfermedades y, en algunos casos, los efectos de las migraciones a largas distancias. Lo que dio como resultado que, dentro de la población originaria del continente americano, exista una baja diversidad genética y una gran diferenciación con las poblaciones nativas del resto de mundo.

Otro periodo clave en la historia de las poblaciones indígenas americanas fue la llegada de los europeos, que tuvo un impacto muy profundo en el acervo genético de la población amerindia; al originar cuellos de botella poblacionales causados por: las epidemias, la esclavitud, guerras y hambrunas.

En el análisis del cromosoma Y, es común encontrar al haplogrupo Q con frecuencias del 100% en Mesoamérica y Sudamérica; mientras que cerca del 97% de las poblaciones originarias de América tiene ADN mitocondrial de los haplogrupos distintivos A, B, C o D, todos de origen asiático. La principal característica genética que diferencia a los pueblos originarios de América de los demás grupos humanos del mundo, es la predominancia del grupo sanguíneo O.
SÍNDROME DE CUTTING (AUTOLESIONISMO)
Authors: Carvajal Oviedo Hugo Eduardo , Arancibia Andrade Boris , Díaz Nogales Jorge Ramiro , Salgueiro Apaza Geraldine
Published: April 2023

El Síndrome de Cutting es el acto de auto lesionarse con el fin de alterar un estado de ánimo, terminar con un estado de confusión emocional o aliviar una situación que implique estrés infligiéndose un daño físico en el cuerpo. El propósito último no es el suicidio, tampoco obtener placer o como ritual para pertenecer a un grupo. Se observa frecuentemente en adolescentes y la ubicación corporal es generalmente en las muñecas y el medio es cualquier objeto afilado (ej. hoja de afeitar).

Desde el punto de vista las ciencias biológicas y neuroquímicas, este síndrome se relaciona con niveles bajos de serotonina. Entre los factores psicológicos predisponentes se tiene la existencia de abuso físico o sexual, negligencia física o emocional y condiciones familiares disfuncionales durante la infancia y adolescencia. El ciclo de desarrollo del síndrome indica que el paciento con Cutting necesitará cortarse cada vez as para obtener el mismo resultado. El abordaje de: estos pacientes es psicológico y psiquiátrico, el paciente requiere psicoterapia y farmacoterapia
COMPORTAMIENTO DE LA RESISTENCIA DE Escherichia coli AL CIPROFLOXACINO EN UROCULTIVOS DE PACIENTES DEL HOSPITAL VIRGEN DE COPACABANA, LA PAZ - BOLIVIA GESTIONES 2004, 2006 Y 2012
Authors: del Pozo Tatiana , Vaca Villanueva Kevin Luis , Zalles García Nicole Katherine
Published: April 2023

La infección del tracto urinario es una infección bacteriana común y muchas veces pasa por un subregistro, lo cual que hace difícil reconocer su verdadera incidencia en el tiempo, por lo tanto se requiere un diagnóstico clínico y un urocultivo positivo confirmatorio. Recientemente, se observaron reportes en crecimiento referidos a la resistencia de Escherichia coli al Ciprofloxacino, por lo que este trabajo busca determinar el comportamiento del mismo en nuestro medio.

El trabajo se realizó en el Hospital Virgen de Copacabana. El estudio fue de tipo retrospectivo y descriptivo. Los principales resultados se tradujeron en un incremento paulatino de urocultivos positivos para resistente a Ciprofloxacino. Se analizaron 314 urocultivos en total, de los cuales, 151 presentaron reportes de resistencia al Ciprofloxacino.

Se comprueba el incremento en la frecuencia de urocultivos con E coli resistente a la Ciprofloxacino a través del tiempo, identificando la responsabilidad del uso antibiótico como esencial para el éxito terapéutico.
RESISTENCIA A QUINOLONAS EN AISLADOS CLÍNlCOS DE Escherichia coli UROPATOGÉNICA EN PACIENTES HOSPITALIZADOS Y AMBULATORIOS PROCESADOS EN EL LABORATORIO CLÍNlCO CENTRAL DE LA CIUDAD DE COCHABAMBA A PARTIR DEL MES DE SEPTIEMBRE A DICIEMBRE DE 2015
Authors: Villarroel Mirtha , Uriona Trigo Ximena
Published: April 2023

Las infecciones del tracto urinario constituyen una de las enfermedades infecciosas más comunes a nivel mundial, que afectan principalmente al sexo femenino. El principal agente causante de estas infecciones es la Escherichia coli uropatogénica (UPEC) responsable en un 70-95% de los casos de infecciones del tracto urinario.

Es bien sabido que en nuestro medio muchas de las personas que sufren de un episodio de infección urinaria recurren a las farmacias en busca de un antibiótico que alivie su malestar; acción que da lugar a un fracaso terapéutico. Es por este motivo que este trabajo tiene como objetivo determinar la resistencia a las Quinolonas en aislados clínicos de Escherichia coli uropatogénica en pacientes hospitalizados y ambulatorios; procesados en el Laboratorio Clínico Central de la Ciudad de Cochabamba a partir del mes de septiembre a diciembre de 2015.

Se realizó un estudio del tipo no experimental, transversal, donde se tomaron en cuenta los datos proporcionados por el cuaderno de registro del laboratorio de 142 pacientes, cuyas edades oscilaban entre 18 a 94 años.

Se encontró que en el 76% de los pacientes infectados, la Escherichia coli presentó resistencia al Ácido Nalidíxico; en cambio sólo el 50% presentó resistencia frente a las fluoroquinolonas: Ciprofloxacina y Levofloxacina. Con respecto al estado de los pacientes, el 78% de la bacteria que infectó a los pacientes ambulatorios presentó resistencia al Acido Nalidíxico, frente al 64% que infectó a los pacientes internados. En cambio, la resistencia observada frente a la Ciprofloxacina y Levofloxacina fue de un 52% en ambulatorios y 36% en internados.
Vingt ans de décroissance : Quel bilan ?
Authors: LATOUCHE Serge
Published: April 2023

To take stock of twenty years of degrowth is of course to take note of the progress of this idea in society and of the initiatives to implement the project in practice, which constitutes its assets. But it also means taking into account the liabilities. The latter concerns not so much the fact that the project did not succeed overall, but more so the examination of the various strategies implemented to neutralize it, or even to attempt to recover it, in order to better appreciate where we are. Since things have not moved much, in terms of concrete measures, it is thus important to identify more precisely the opponents of a political program of degrowth and the obstacles to the realization of an ecocompatible society.
La décroissance a des racines, il lui faut maintenant des ailes : réactiver l’imaginaire, réoutiller la démocratie avec la prospective participative
Authors: BRIENS François
Published: April 2023

Although the myth of perpetual providential growth is loosing traction, degrowth ideas still struggle to materialize into concrete socio-political transformations. Degrowth proposals and narratives often remain vague and abstract, which hinders political adoption. In this context, prospective tools can help define and refine proposals and assess their potential, to enlighten collective deliberation. Prospective approaches could usefully feed direct and continuous democratic processes, the deployment of which should be the common goal and priority for all social struggles, for this fight contains them all.