bluuebunny/crossref_metadata_2025 huggingface dataset:
Research Topic Trends In Information And Communication Technology Indexed Science And Technology Index (Sinta) 1 Year 2021 With The Zipf Approach
Authors: Via  , Nining Sudiar  , Amelia Vita
Published: July 2023

ABSTRACT
This study aims to find out about the trend topics that are more often discussed in Information & Communication Technology journals indexed by SINTA 1 in 2021 so that they can bring up the latest research subjects. The method used in this research is to use the bibliometric data analysis method based on the zipf rule. The results showed that there was the word "Learning" which was the highest word frequency, which was 317 times appearing with a percentage (3.8%) of the total 8246 words. Then followed by the word "Network" as much as 258 times (3.1%), then "Neural" is a word that appears 235 times or equivalent to (2.8%), the word "System" is also found 160 times, namely with a percentage (1.9%), followed by the word "Machine" 146 times appearing which is equivalent to (1.8%), then the word "Data" also appearing 135 times with a percentage (1.6%), appearing Also the word "Algorithm" is 127 times with a value (1.5%), the word "Image" appears 124 times with a percentage of (1.5%), the word "Energy" is also found 121 times appears with a value (1, 5%) and the top ten words ended with the word “Deep” which appeared 118 times with a percentage (1.4%). These words can be used as keywords in the research article being studied. The calculation above shows that the relevant subject index is greater with the relevant percentage of 62.5%, relevant marginal of 37.5% and irrelevant of 0 %.
Keywords : Zipf rules, Bibliometrics, Journals, Articles, Words: Learning

 
Tren Topik Penelitian Jurnal Teknologi Informasi Dan Komunikasi Terindeks Science And Technology Index (Sinta) 1 Tahun 2021 Dengan Pedekatan Dalil Zipf
ABSTRAK
Penelitian ini bertujuan untuk mengetahui permasalahan tentang tren topik-topik apa saja yang lebih sering dibahas dalam jurnal Teknologi Informasi dan Komunikasi yang terindeks SINTA 1 pada tahun 2021 sehingga bisa memunculkan subjek penelitian terbaru. Metode yang digunakan pada penelitian ini yaitu menggunakan metode analisis data bibliometrik dengan berdasarkan kaidah zipf. Hasil penelitian ini menunjukkan bahwa terdapat kata “Learning” merupakan frekuensi kata tertinggi yaitu sebanyak 317 kali muncul dengan jumlah persentase (3,8%). Maka dapat diambil kesimpulan bahwa kata tersebut dapat dijadikan sebagai kata kunci (Keyword) pada penelitian artikel yang sedang diteliti. Perhitungan diatas menunjukkan indeks subjek yang nilainya relevan lebih besar dengan jumlah persentase relevan sebesar 62.5%, persentase relevan marginal sebesar 37,5% dan jumlah persentase tidak relevan sebesar 0 %.
Keywords: Kaidah Zipf, Bibliometrik, Jurnal, Artikel, Kata: Learning.
Prognostic value of the levels of CTLA-4 and its ligand B7.2 in patients with colorectal cancer
Authors: Chetveryakov A. V. , Tsepelev V. L.
Published: July 2023

Aim. To develop a computer program to determine the probability of colorectal cancer based on the assessment of the levels of CTLA-4 and its ligand B7.2.

Materials and methods. The study included 44 patients with colorectal cancer (CRC) and 25 patients with benign tumors of the colon. The control group consisted of 25 individuals who had been operated for colon injury. We determined the levels of CTLA-4 and B7.2 in the blood serum and in the supernatants of tumor tissue and lymph node homogenates using flow cytofluorometry.

Results. We found that the level of CTLA-4 in the blood serum increased by 2.77 times in CRC patients compared to the control group (p < 0.001). The concentration of CTLA-4 in the tumor tissue in patients with CRC was 2.34 times higher than in the control group (p = 0.007). The concentration of the B7.2 ligand in the blood serum of patients with CRC exceeded this parameter in the control group by 2.51 times (p = 0.002). The concentration of B7.2 in the tumor tissue of CRC patients was 1.68 times higher (p = 0.004) than in the control group. The analysis of the obtained data determined the parameters that have prognostic value in the structure of the diagnostic model. Using these parameters, we developed a computer program to determine the probability of CRC in the patient.

Conclusion. The data obtained demonstrate an increase in the levels of CTLA-4 and its ligand B7.2 in the serum and tumor tissue of patients with CRC.
Conservação pós-colheita da cebolinha em baixa temperatura como sinôni-mo de otimização produtiva
Authors: Colombo Belfort Cristovam , Dantas Martins Daniel Aleff , Almeida de Paula Gabriela , Rocha Júnior Agenor Francisco , Da Costa Filho Raimundo Tomaz
Published: July 2023

A Cebolinha (Allium schoenoprasum) é uma planta condimentar, aromática, folhosa, apreciada em todo o Brasil, com importante papel social, preponderante nos projetos de agricultura familiar. Muito embora sendo uma espécie com elevada cerosidade foliar, propriedade que lhe confere uma certa tolerância à desidratação, colocadas no conservador doméstico, em poucos dias sofre descoloração, comprometendo a qualidade do produto, redundando em consideráveis perdas, sobretudo, para o consumidor. Diante disso, o presente trabalho buscou avaliar a conservação pós-colheita de folhas da cebolinha, submetidas ao acondicionamento em baixa temperatura. Todo o processamento ocorreu no laboratório do Núcleo de Estudos, Pesquisas e Processamento de Alimentos (NUEPPA) do Centro de Ciências Agrárias (CCA) da Universidade Federal do Piauí, em Teresina, entre agosto e novembro de 2020. Os tratamentos consistiram das análises de amostras retiradas quinzenalmente até o limite de 75 dias, ficando o tratamento testemunha correspondendo às amostras, recém-colhidas, as quais também foram submetidas às determinações de natureza físico-química. Verificações complementares de natureza sensorial foram realizadas, envolvendo cor, aroma e textura, sendo então considerados atributos de qualidade. A refrigeração favoreceu o prolongamento da vida útil da cebolinha, sem variação nas características físico-químicas testadas, demonstrando que é possível conservá-la em refrigerador à baixa temperatura (-20oC) acondicionada em sacos plásticos por, pelo menos 75 dias, sem comprometimento da qualidade do produto; otimizando o aproveitamento da mão de obra familiar, criando as perspectivas de lançamento de um novo produto no rol dos congelados.
Naturalização de Hibiscus sabdariffa L. em região de transição dos Biomas Pantanal, Floresta Amazônica e Cerrado
Authors: Marcos Silva Valentim Sebastião , Baptista da Luz Petterson , Laura Oliveira Cardoso Elaidy , Moretto Gabriel , Carlos Silva Moreira Antônio , Júlia Cardoso Amaral Anna , Samy de Oliveira Miranda Bruna
Published: July 2023

A espécie Hibiscus sabdariffa L. é originária do continente Africano. Trata-se de uma espécie arbustiva que pode chegar até 2 m de altura, onde devido aos seus vários usos, se espalhou para diversas regiões no mundo, onde atua de forma exótica, podendo se tornar uma espécie naturalizada. Na cidade de Cáceres- MT existe uma pequena população da espécie em uma área antropizada, no qual, de acordo com os moradores locais, as plantas já estão presentes no local há vários anos, mesmo havendo diversas vezes a ocorrência de perturbações na área. Sendo assim, o objetivo do trabalho foi analisar a possível naturalização de Hibiscus sabdariffa em uma localidade antropizada presente na região de transição dos Biomas Pantanal, Floresta Amazônica e Cerrado na cidade de Cáceres- MT. Para a execução do trabalho realizou-se uma pesquisa qualitativa, de natureza exploratória e descritiva, pesquisa bibliográfica sobre Hibiscus sabdariffa e sobre naturalização de plantas. Os dados sobre as perturbações foram coletados através de observações ao decorrer dos anos e por entrevistas com pequenos produtores que residem na comunidade. A pequena população da espécie Hibiscus sabdariffa encontrada na comunidade rural em Cáceres- MT possui as características de naturalização, podendo assim, ser considerada uma espécie naturalizada no local e participante da biodiversidade local. Além disso, o fato de a espécie estar presente na área há vários anos mesmo com as perturbações recorrentes, reforça a ocorrência de naturalização.
Marketability Study of Mathematical Sciences Students in Universiti Kebangsaan Malaysia (UKM)
Authors: Lim Chui Ting  , Ong Wen Xuan  , Muhammad Aris Fadzilah Nurulain Nabilah Binti , Nora Binti Muda
Published: July 2023

Higher Education Institute (HEI) has a vital role in developing human capital of a country. Measuring the quality of teaching and learning system in HEI and also industry’s satisfaction level is important to ensure the marketability of HEI graduates. This study examined Universiti  Kebangsaan Malaysia (UKM) Mathematical Sciences students’ marketability by determining industry’s satisfaction level on students’ skills and abilities during industrial training and identifies factors that affect students’ marketability. There were 22 student attributes that were categorized into four factors. Mean scores and Relative Importance Analysis determined the satisfaction and importance level of each attribute studied respectively. Besides, Penalty-Reward Contrast Analysis (PRCA) showed that affective factor was categorized as a basic factor where its existence did not increase but its absence decreased the industry’s satisfaction level. For Importance Performance Analysis (IPA), cognitive, affective, and cognitive & psychomotor factors were observed in the first quadrant which had high importance level but low performance level. Lastly, all four factors were found in the loyal customer zone and at an excellent level through Customer Satisfaction Index (CSI) analysis. In conclusion, UKM Mathematical Sciences students have high marketability in general, but preservation and improvement should be implemented on important attributes to enhance their marketability.
Space Theory
Authors: Chen S.
Published: July 2023

The author introduces a novel theoretical framework that suggests matter and energy are both converted from curved space. In Space Theory, gravitation is generated by the flow of space, instead of being transmitted by the graviton as in String Theory. This theory also suggests that Newton's gravitational constant, denoted as G, may not be truly constant but could vary over time. The equivalent equation of space is S=Ec2=mc4, and the gravitation of hollow sphere space is Sμν=4πGm=(4/3)π((r+a)3-r3). The Space Theory also predicts that the surface gravitational acceleration of the neutron star Crab Pulsar (PSR B0531+21) is approximately 8.21924883×106 m/s2.
Rereading Jürgen Essletzbichler’s Chapter – “Locating Location Models”
Authors: Ahn Young-Jin , Juraev Zuhriddin
Published: July 2023

This article, inspired by Dr. Jürgen Essletzbichler’s chapter namely “Locating Location Models” in The SAGE Handbook of Economic Geography (2011), delves into the legacy and significance of location theory. By examining its integration of historical analysis and theoretical abstraction, the study highlights the crucial role played by historical and geographical contexts in shaping spatial patterns. It emphasizes the importance of complementing abstract models with historical analysis to gain a deeper understanding of real-world spatial phenomena. Acknowledging the delay in the development of location theory attributed to the dominance of the German historical school, the article recognizes its enduring value and resurgence in the realm of modern evolutionary economic geography. Ultimately, the abstract underscores the contributions of location theory to our comprehension of spatial dynamics and its potential for further advancements in the field of economic geography.
The Development of UAV Airframes Made of Natural Fibers:A Review
Authors: Rajoo Previndran Guinda , Sultan Mohamed Thariq Hameed , Łukaszewicz Andrzej , Basri Adi Azriff , Shah Ain Umaira Md , Nayak Suhas Yeshwant , Grzejda Rafał , Holovatyy Andriy
Published: July 2023

Natural fibers have been widely used as a reinforcing material for the construction of drones. The main goal of this review is to identify a biodegradable natural fiber material that can be built for Unmanned Aerial Vehicles (UAVs). The review shows that natural fibers such as kenaf and PALF can be used as an alternative composite material, particularly for multifunctional applications where their smaller weight and less expensive characteristics make them incredibly realistic. This review also discusses the mechanical properties, advantages and disadvantages, and fabrication of the composites.
Measuring Performance of a Strategic Asset Management Plan through a Balanced Scorecard
Authors: De-Almeida-e-Pais J. Edmundo , Raposo Hugo D. N. , Farinha José Torres , Cardoso Antonio J. Marques , Lyubchyk Svitlana , Lyubchyk Sergiy
Published: July 2023

The purpose of this paper is to propose a tool to measure the performance of a Strategic Asset Management Plan (SAMP) based on a Balanced Scorecard (BSC). The SAMP converts organizational objectives into asset management objectives, also specifies the role of the asset management system and brings support to achieve asset management objectives. The SAMP becomes the heart of the organization and integrates with long-term, medium-term, and short-term financial plans integrated with same term activity plans. In the SAMP, the balance among performance, costs and risks is also taken into consideration in order to achieve the organization’s objectives. On the other side, the SAMP is a guide to set the asset management objectives while describing the role of the Asset Management System (AMS) in meeting those objectives. While SAMP is the central figure of AMS, it is important to measure its performance and needs to be build and improved through an iterative process, what means that is not just a document, it is “the document”, and should be treated as a “living being” that needs to adapt to internal and external changes quickly. The BSC is an excellent tool where, through the appropriate Key Performance Indicators (KPIs), the progress can be measured, and is supported by four perspectives: Financial; Customer; Internal Process; and Learning and Growth.
Experimental and Numerical Process Design for Press Partitioning of the New Q&P Steel 37SiB6
Authors: Illgen Christian , Winter Sven , Haase Rico , Böhme Marcus , Reiser Nadja , Hatscher Ansgar , Psyk Verena , Kräusel Verena , Wagner Martin F.-X.
Published: July 2023

Limited availability of expensive alloying elements elevates low-alloyed steels to a unique position in the field of lightweight construction and mass production. Quenching and partitioning (Q&P) heat treatments of low-alloyed steels with exceptional property combinations are particularly promising. In this study, we characterize for the first time a new low-alloyed steel to be processed by Q&P heat treatments. In combined experimental and numerical studies, we design a novel approach that effectively combines the short cycle times of press hardening with the excellent property profiles of Q&P-treated steels. We identify appropriate transformation parameters for Q&P heat treatments by dilatometric studies and we adjust a number of reference conditions with different isothermal holding times. By means of SEM analysis and XRD measurements, we show that different fractions of retained austenite result in different mechanical properties. Initial numerical designs of the process can identify varying temperature profiles and cooling rates depending on the position in the die. The results show that the geometry of the part plays a minor role, but the die temperature is the dominant factor for successful partitioning directly in the press hardening process.
Modelling the Factors Affecting the Adoption of Compound Feed in Dairy Animal Feeding
Authors: D Thirunavukkarasu , M Jothilakshmi
Published: July 2023

Smallholder dairying engages around 70 to 80 million rural households who are mostly landless, small and marginal farmers. These farmers face challenges in terms of adoption of balanced feeding practices including inclusion of compound feed in animal feeding. This necessitates to understand the socio-economic factors that are influencing the adoption of compound feed. The study found that 51% of dairying households adopted compound feed in animal feeding. The adopters and non-adopters of compound feed differed (P< 0.01) in terms of land holding, family educational status, breeds owned, membership status in farmer’s collectives, fodder adoption, area under fodder, access to grazing resources, availability of crop residues, milk production and milk marketing opportunities. Furthermore, users and non-users of compound feed had significant difference (P< 0.05) in extension agency contact, mass media contact, attitude towards dairying and gender participation in farming. The logit regression model explained the variance in adoption to 30%. Further it indicated the role of selective socio-economic characters, farming situations, feeding and marketing practices in adoption of compound feed. In specific membership in farmer’s collectives, marketing opportunity, milk production, farm men participation, family education status, grazing resources and attitude towards dairying has greatly influenced the adoption behaviour of compound feed in positive direction. Added, households with high experience, cultivating fodder and having access to crop residues tend to influence the adoption decision negatively. The research observed that farmers tend to use compound feed for increasing productivity in areas of better markets and there exists trade-offs between milk market opportunities, access to cheaper roughages and usage of compound feed.
A digitális oktatás face-to-face szóbeli kommunikációjának jellemzői és illemtana
Authors: Dobos Dóra , Vígh-Szabó Melinda
Published: July 2023

A tanulmány a 2020 tavaszán bevezetett digitális oktatás valós idejű, tanár-diák között zajló kommunikáció etikettjével foglalkozik. A kutatásban középiskolákban és általános iskolákban tanító pedagógusok vettek részt (n = 142), akik egy 23 kérdésből álló online kérdőív segítségével fogalmazták meg a tapasztalataikat. A felmérésből kiderült, hogy a tanárok milyen felületeket és milyen motivációs eszközöket alkalmaztak a diákok érdeklődésének a fenntartására, illetve az új munkarendhez való alkalmazkodás során milyen szabályokat hoztak a szinkrón digitális kommunikáció hatékonysága érdekében (öltözködés, háttér, kameraképben látható környezet rendezettsége, ruházat, evés-ivás, óra közbeni felállás, kamera- és mikrofonhasználat, időkeretek betartása). Az eredmények azt mutatják, hogy a magyar közoktatásban nem volt egységes protokoll a távolléti oktatás online kommunikációjára. Ez egyrészt megnehezítette a tanárok és a diákok kapcsolattartását, másrészt az oktatás hatékonyságát is csökkentette.
Élményalapú nyelvtörténet
Authors: Sarnyai Vivien
Published: July 2023

2015-ben megalakult az ELTE Alkalmazott Nyelvtörténeti Kutatócsoportja, amely – többek között – a nyelvtörténet közoktatásban betöltött szerepét helyezte a középpontba. Ez a résztéma időközben önálló kutatási területté vált, és megalakult az ELTE Benkő Loránd Nyelvtörténeti Hallgatói Műhely vezetése alatt a Nyelvtörténet az oktatásban elnevezésű kutatócsoport. A kutatás fókuszában a pedagógusok és a diákok nyelvtörténet iránti attitűdje állt. A magyartanárokkal készített interjúk azt igyekeztek feltérképezni, hogy a pedagógusok a nyelvtörténetnek milyen témaköreit érintik, milyen nehézségekbe ütköznek, és hogy az egyetemtől milyen segítséget várnak. Ez utóbbira a leggyakoribb válasz az volt, hogy jelentősen segítené a munkát, ha rendelkezésükre állna egy középiskolásoknak szánt nyelvtörténeti feladatgyűjtemény. A kutatócsoport ennek a kívánalomnak igyekezett eleget tenni, így 2020 tavasza óta több mint 200 feladat készült el, amely hamarosan feladatgyűjteményként fog napvilágot látni.
El zombi desde el punto de vista de la evolución y la prehistoria
Authors: Lombo Montañés Alberto
Published: July 2023

En el presente artículo demostraremos por qué la prehistoria es importante para conocer el fenómeno zombi. Intentamos averiguar la relación de la figura del zombi con el imaginario prehistórico a través de los medios audiovisuales. Primero el zombi tradicional, surgido del folklore y segundo el zombi moderno, surgido de las películas de George A. Romero. Veremos cómo algunos aspectos del zombi moderno se relacionan con la evolución, el primitivismo o el canibalismo, como practicas supuestamente ligadas a la prehistoria.
Evaluación in vitro del efecto antibacteriano del propóleo frente a Klebsiella pneumoniae y Staphylococcus aureus
Authors:   , Chumbiray Velasquez Milagros Estefany Peregrina , Ochoa Castro Carlos Eduardo
Published: July 2023

Objetivos: Determinar el efecto antibacteriano “in vitro” del propóleo frente a Klebsiella pneumoniae y Staphylococcus aureus. Materiales y métodos: Estudio experimental “in vitro”, tipo analítico, prospectivo. Se utilizó 1 litro de propóleo a concentración de 10% procedente de la ciudad Tarapoto y se determinó los grupos funcionales por screening químico. El efecto antibacteriano se determinó mediante la concentración mínima inhibitoria (CMI) frente a Staphylococcus aureus ATCC 25923 y Klebsiella pneumoniae BAA1706 mediante el método de microdilución. Resultados: Se encontraron en la muestra compuestos bioactivos como: catequinas, alcaloides. Fenoles, flavonoides, glicósidos cardiotónicos, resinas, antocianidinas, taninos entre otros. La CMI del propóleo crudo fue de 0.902 mg/ml frente a K. pneumoniae y 0.451 mg/ml frente a S. aureus; por otro lado, la resina obtuvo una CIM de 0.783 mg/ml frente a K. pneumoniae y 0.391 mg/ml frente a S. aureus. Conclusiones: El propóleo de Tarapoto-Perú tiene una actividad antimicrobiana frente a S. aureus ATCC 25923 y K. pneumoniae BAA1706, revelando su posible potencial como fármaco sinérgico para combatir afecciones dadas por las bacterias mencionadas, además de disminuir la resistencia antimicrobiana.
Asociación entre el empoderamiento de la mujer peruana y la elección del lugar de parto. Análisis de una encuesta nacional, 2018
Authors:   , Hernandez Cueva Gerald Alexander , Nieves Ramirez Rhisto Guillermo
Published: July 2023

Introducción: Perú es una región con alta prevalencia de mortalidad materna y neonatal, a pesar de ello, la mayoría de las mujeres no reciben una atención adecuada durante el embarazo, parto y posparto, aún más, cuando existen barreras económicas, culturales y geográficas que dificultan la atención de las mujeres embarazadas. Objetivo: Determinar la asociación entre la autonomía de las mujeres peruanas y el lugar del parto. Métodos: Se realizó un estudio transversal analítico de los datos secundarios provenientes de la Encuesta Demográfica y de Salud Familiar del año 2019. La variable dependiente fue el parto institucionalizado y la variable independiente fue la autonomía de la mujer. Se evaluó la asociación entre la autonomía de las mujeres y el parto institucionalizado mediante modelos lineales generalizados de la familia Poisson con función de enlace logarítmica y se estimaron las razones de prevalencia crudas y ajustadas (RP) con sus respectivos intervalos de confianza (IC) al 95%. Resultados: El análisis incluyó a 15334 mujeres de 15 a 49 años. Se encontró que una alta proporción de mujeres tenía un bajo nivel de autonomía (42,60%), mientras que el 92,11% tuvo parto institucionalizado. Asimismo, se reportó que los niveles de autonomía de la mujer moderado (RP: 1,10; IC 95%: 1,08 - 1,12) y alto (RP: 1,13; IC 95%: 1,12 - 1,15) estaban asociados con el parto institucionalizado, y la misma asociación se encontró en el análisis ajustado. Conclusión: Ser una mujer con un mayor nivel de autonomía se relacionó con una mayor probabilidad de parto institucionalizado. Por lo tanto, al ser la toma de decisión una característica multifactorial, sería necesario ahondar en el estudio de los determinantes del parto no institucional en mujeres con menor autonomía.
Modulation of temporal and occipital cortex by acupuncture in non- menstrual MWoA patients: A Rest Bold fMRI study
Authors: Yang Yu-Chan , Wei Xiang-Yu , Zhang Ying-Ying , Xu Chun-Yang , Cheng Jian-Ming , Gong Zhi-Gang , Chen Hui , Huang Yan-Wen , Yuan Jie , Xu Hui-Hui , Wang Hui , Zhan Song-Hua , Tan Wen-Li
Published: July 2023

Objective
To investigate the changes in amplitude of low-frequency fluctuation (ALFF) and degree centrality (DC) values before and after acupuncture in young women with non-menstrual migraine without aura (MWoA) through rest blood-oxygen-level-dependent functional magnetic resonance imaging (BOLD fMRI).
Methods
Patients with non-menstrual MWoA (Group 1, n = 50) and healthy controls (Group 2, n = 50) were recruited. fMRI was performed in Group 1 at 2 time points: before acupuncture (time point 1, TP1); and after the end of all acupuncture sessions (time point 2, TP2), and performed in Group 2 as a one-time scan. Patients in Group 1 were assessed with the Migraine Disability Assessment Questionnaire (MIDAS) and the Short-Form McGill Pain Questionnaire (SF-MPQ) at TP1 and TP2 after fMRI was performed. The ALFF and DC values were compared within Group 1 at two time points and between Group 1 and Group2. The correlation between ALFF and DC values with the statistical differences and the clinical scales scores were analyzed.
Results
Brain activities increased in the left fusiform gyrus and right angular gyrus, left middle occipital gyrus, and bilateral prefrontal cortex and decreased in left inferior parietal lobule in Group 1, which had different ALFF values compared with Group 2 at TP1. The bilateral fusiform gyrus, bilateral inferior temporal gyrus and right middle temporal gyrus increased and right angular gyrus, right superior marginal gyrus, right inferior parietal lobule, right middle occipital gyrus, right superior frontal gyrus, right middle frontal gyrus, right anterior central gyrus, and right supplementary motor area decreased in activity in Group 1 had different DC values compared with Group 2 at TP1. ALFF and DC values of right inferior temporal gyrus, right fusiform gyrus and right middle temporal gyrus were decreased in Group1 at TP1 compared with TP2. ALFF values in the left middle occipital area were positively correlated with the pain degree at TP1 in Group1 (correlation coefficient r, r = 0.827, r = 0.343; P < 0.01, P = 0.015). The DC values of the right inferior temporal area were positively correlated with the pain degree at TP1 in Group 1 (r = 0.371; P = 0.008).
Conclusion
Spontaneous brain activity and network changes in young women with non-menstrual MwoA were altered by acupuncture. The right temporal area may be an important target for acupuncture modulated brain function in young women with non-menstrual MwoA.
Support Vector Data Description with Kernel Density Estimation (SVDD-KDE) Control Chart for Network Intrusion Monitoring
Authors: Ahsan Muhammad , Khusna Hidayatul , Wibawati Wibawati , Lee Muhammad Hisyam
Published: July 2023

Multivariate control charts have been applied in many sectors. One of the sectors that employ this method is network intrusion detection. However, the issue arises when the conventional control chart faces difficulty monitoring the network-traffic data that do not follow a normal distribution as required. Consequently, more false alarms will be found when inspecting network traffic data. To settle this problem, support vector data description (SVDD) is suggested. The control chart based on the SVDD distance can be applied for the non-normal distribution, even the unknown distributions. Kernel density estimation (KDE) is the nonparametric approach that can be applied in estimating the control limit of the non-parametric control charts. Based on these facts, a multivariate chart based on the integrated SVDD and KDE (SVDD-KDE) is proposed to monitor the network's anomaly. Simulation using the synthetic dataset is performed to examine the performance of the SVDD-KDE chart in detecting multivariate data shifts and outliers. Based on the simulation results, the proposed method produces better performance in detecting shifts and higher accuracy in detecting outliers. Further, the proposed method is applied in the intrusion detection system (IDS) to monitor network attacks. The NSL-KDD data is analyzed as the benchmark dataset. A comparison between the SVDD-KDE chart with the other IDS-based-control chart and the machine learning algorithms is executed. The results show that the IDS based on the SVDD-KDE chart produces a high accuracy at 0.917 with a low false positive rate at 0.062 compared to several algorithms.
Unlocking the Antioxidant and Antimicrobial Potential of Flavone and Amide-rich Fractions from Conchocarpus macrocarpus (Rutaceae) Leaves
Authors: Silveira Elielson Rodrigo , Torres Priscila Bezerra , Scortecci Katia Castanho , Rocha Hugo Alexandre Oliveira , Suffredini Ivana Barbosa , Silva Jefferson de Souza , Santos Déborah Yara Alves Cursino dos
Published: July 2023

Conchocarpus macrocarpus (Rutaceae) is an endemic species in Brazil, whose chemical and biological properties are poorly understood. This study aimed to evaluate the antioxidant and antimicrobial potential of the butanolic partition phase extracted from C. macrocarpus leaves collected in Espírito Santo, Brazil. In vitro antioxidant assays, including DPPH radical scavenging and Folin-Ciocalteu assay, and cytotoxicity and antioxidant activity in RAW cells using the MTT method were performed. Additionally, antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Candida albicans was investigated. Results showed that the flavone-rich fraction exhibited the strongest antioxidant activity, as observed for the PF-BuOH G2.1 fraction that showed values of 237.2 ± 1.4 mg TE/g of extract and 118.2 ± 1.6 mg GAE/g of extract. However, the samples did not show protective effects against hydrogen peroxide. Furthermore, the flavones and amides present in the PF-BuOH G2.1 fraction displayed antimicrobial activity against C. albicans, showing a minimum inhibitory concentration of 1.25 mg/mL at the highest microbial load (1.5x105 CFU/mL). Our findings provide insights into the chemical composition and biological potential of C. macrocarpus and highlight the promising applications of the BuOH partition phase and its fractions.
Vehicle License Plate Recognition Algorithm Based on Deep Learning
Authors: Li Qiaojun
Published: July 2023

With the gradual increase of car ownership in China, license plate recognition plays an important role in intelligent vehicle management system. The existing vehicle number recognition algorithms have slow recognition speed and low accuracy, and are easy to be affected by the light, the position angle of the license plate and the relative fixed position of the camera. The Faster-RCNN based on deep learning locates the license plate, generates the license plate extraction frame and extracts the license plate; Use VGGnet network model to recognize characters, and finally complete the recognition of car license plate. Training and testing are carried out in a large number of data sets. The simulation results show that the network model combining fast RCNN and VGGnet can recognize the license plate with an accuracy of 99.2% in a complex environment, and the recognition accuracy is better than other algorithms.
Correlation of preoperative hematological markers with clinicopathological features of LSCC
Authors: Qi Hui , Han Shifan
Published: July 2023

Objective
This study aimed to examine the relationship between hematological markers and the detection and diagnosis of LSCC, the development of carcinoma, and their clinical importance.
Methods
Patients with LSCC were searched through the laryngeal cancer-specific database. Clinical data such as sex, age, clinical classification, T-stage, N-stage, pathological stage, smoking and drinking habits, blood routine, biochemical examination, and coagulation examination were collected, and all data were processed by SPSS 23.0 statistical software, and P < 0.05 was considered a statistically significant difference.
Results
Clinical classification and pathological stage were correlated with NLR, PLR, and LMR levels (P < 0.05). There was a correlation between the T stage and NLR levels (P < 0.05). There was a correlation between smoking and LMR level (P < 0.05). PLT levels were linked with age, T stage, N stage, and alcohol consumption (P < 0.05). T stage and N stage were connected with PDW levels (P < 0.05). Sex, clinical classification, and HB levels were associated (P < 0.05). Age, clinical classification, and N stage were connected with ALB level (P < 0.05). Age, clinical classification, pathological stage, T stage, N stage, and alcohol consumption were connected with PA level (P < 0.05). There was a correlation between sex and APTT level (P < 0.05). Clinical classification, T stage, and FIB level were associated (P < 0.05).
Conclusion
Increased levels of NLR, PLR, PLT, and FIB and decreased levels of LMR, MPV, PDW, HB, ALB, and PA are associated with poor clinicopathological features of LSCC. Hematological markers are important in monitoring cancer progression, guiding treatment, and predicting prognosis.
Role of FoxO1 in pulmonary artery endothelial autophagic function in chronic thromboembolic pulmonary hypertension rats
Authors: Wu Dawen , Wu Shuang , Yang Minxia , Li Hongli , Wang Wenfeng , Chen Yunfei , Deng Chaosheng
Published: July 2023

Aims
To detect the effect of forkhead box transcription factor O-1 (FoxO1) on autophagy of pulmonary artery in chronic thromboembolic pulmonary hypertension (CTEPH) rats.
Methods
Rats were divided into sham group and three experimental groups. In the experimental group, autologous blood clots were injected into the right jugular vein of rats to induce the CTEPH animal model. The experimental group was randomly divided into three groups, thrombosis group (n = 24), FoxO1 agonist treatment group (resveratrol) (n = 24) and FoxO1 inhibitor treatment group (AS1842856) group (n = 24). The mean pulmonary arterial pressure (mPAP), the area of pulmonary artery wall/total area (WA/TA) and the expression levels of FoxO1, pFoxO1, LC3 and Beclin1 in pulmonary artery were measured.
Results
The mPAP and WA/TA ratio in the FoxO1 agonist group were decreased significantly (P < 0.05). The mPAP and WA/TA ratio in the FoxO1 inhibitor were increased significantly (P < 0.05). The mPAP was negatively correlated with pFoxO1 in experimental group (r=-0.967, P < 0.001), the expression of pFoxO1 protein was positively correlated with FoxO1 protein expression (r = 0.972, P < 0.001), expression of LC3 protein was positively correlated with the expression of pFoxO1 protein (r = 0.871, P < 0.001), Beclin1 protein expression was positively correlated with pFoxO1 protein expression (r = 0.953, P < 0.001).
Conclusion
There is a decreased autophagy activity and FoxO1 expression of pulmonary artery in CTEPH rats. FoxO1 may be involved in pulmonary artery remodeling process and contribute to the development of CTEPH by regulating autophagy activity, but the concrete mechanism are unknown.
No genetic evidence for the association between COQ7 and Chinese patients with Amyotrophic Lateral Sclerosis
Authors: Yu Weiyi , He Ji , Zheng Wei , Liu Xiaoxuan , Fan Dongsheng
Published: July 2023

Background Amyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disease. Recently, homozygous and compound heterozygous pathogenic variants in theCOQ7gene were identified in patients with Hereditary Spastic Paraplegia (HSP), and distal hereditary motor neuropathy (dHMN). Inspired by the pathological, clinical and genetic overlap of these diseases with ALS, the association betweenCOQ7and the pathogenesis of ALS was studied. Results 3 heterozygous nonsynonymous variants in 3 sporadic ALS (sALS) patients, 0 nonsynonymous variants in familial ALS (fALS) patients, 1 heterozygous missense variant in both the ALS cohort and the control cohort, and 10 heterozygous nonsynonymous variants in the control subjects were identified. No homozygous or compound heterozygous pathogenic mutations were found in patients with ALS. The frequency of rare or likely pathogenic variants was not statistically different between the ALS cohort and the control cohort. Conclusions Our results did not find an association betweenCOQ7and ALS in Chinese patients, and further study may be required.
A novel activation model for myofibroblasts derived from hepatic stellate cells in fibrotic liver
Authors: Yan Mengchao , Xie Ye , Yao Jia , Li Xun
Published: July 2023

Myofibroblasts in liver fibrosis originate from the activation of hepatic stellate cells (HSCs). Traditional activation model contains high expression of α-SMA and COL1A1. Based on traditional model, collagen deposition in the fibrotic liver should constructed in the way of patchy distribution, which is not consistent with the objective situation. We analyzed the expression of α-SMA and COL1A1 in the cell subpopulation with myofibroblast characteristics based on the Single-cell sequencing database Omnibrowser, and the result showed that α-SMA and COL1A1 were negatively correlated. After inducing myofibroblast characteristics of HSCs using fibrotic serum, further intervention with TGF-β1 promotes the expression of α- SMA simultaneously inhibits COL1A1 expression. Multicolor fluorescence of rat fibrotic liver tissue showed a network-like distribution of TGF-β1, while COL1A1 showed a patchy distribution in the TGF-β1 loop. COL1A1 expression was lower near the TGF-β1 loop and higher in the distant region, presenting a centripetal pattern. The difference is that α-SMA expression was mostly concentrated next to the TGF-β1 loop. Therefore, we propose the dual mode transition model of myofibroblasts in fiber liver (DMTM model). In the DMTM model, myofibroblasts have dual modes. Myofibroblasts obtain enhanced migration ability, accompanied by inhibition of COL1A1 expression in the high-concentration region of TGF-β1. When migrating to the periphery of the TGF-positive region, myofibroblasts convert to a high collagen secretion phenotype. The combination of migration to the periphery and collagen secretion promotes the continuous spread of collagen bundles and ultimately forms the observed fiber distribution pattern in the fibrotic liver.
Genetic divergence studies among sand pear (Pyrus pyrifolia (Burm) Nakai.) genotypes for yield and yield contributing traits in North-Western Himalayas
Authors: chauhan akriti , Thakur Dinesh S , Dogra RK , Rana VS
Published: July 2023

Germplasm assets are critical for hereditary breeding, investigation of complex traits and are conducive to the investigation and creation of unused germplasm. In order to effectively measure genetic divergence and character association for sand pear genetic improvement, yield and yield contributing variables were assessed for 125 genotypes during 2018–2021 in three districts of Himachal Pradesh, India (N-W Himalayas). The results indicated that estimates for eye basin, depth stalk cavity depth, fruit stalk length, non reducing sugars and leaf area high had high PCV and GCV values. High heritability and genetic gain both suggests the existence of additive gene action. The fruit's weight, sugar-to-acid ratio, and titratable acidity were reported, these qualities can be enhanced via direct selection. Fruit weight, total sugars, trunk diameter, total soluble solids (TSS), fruit length, fruit breadth, petiole length, and leaf area all have a high direct effect on plant yield, according to studies of association. Therefore, the overall result suggests that there is substantial diversity in the assessed attributes for them to serve as selection indices for genetic improvement of sand pear.
Predictive role of circulating tumor DNA and blood-based tumor mutational burden in esophageal squamous cell carcinoma receiving definitive chemoradiotherapy combined with toripalimab: Exploratory analyses of a phase II study (EC-CRT-001)
Authors: Xi Mian , Chen BaoQing , Liu Shiliang , Zhu Yujia , Wang Ruixi , Cheng Xingyuan , Chen Biqi , Dragomir Mihnea , Zhang Yaru , Hu Yonghong , Liu Mengzhong , Li Qiaoqiao , Yang Hong
Published: July 2023

The combination of toripalimab (an anti-PD-1 antibody) with definitive chemoradiotherapy (CRT) demonstrated encouraging efficacy against locally advanced esophageal squamous cell carcinoma (ESCC) in the EC-CRT-001 phase II trial. This exploratory analysis evaluated the role of circulating tumor DNA (ctDNA) and blood-based tumor mutational burden (bTMB) in predicting the response and survival. We found that ctDNA-negative patients achieved a higher clinical complete response rate (cCR) compared to those with detectable ctDNA during CRT (83%, 19/23 vs. 39%, 7/18; p=0.008) or post-CRT (78%, 21/27 vs. 30%, 3/10; p=0.017). Patients with detectable ctDNA during CRT had shorter progression-free survival (PFS) (p=0.014). Similarly, patients with post-CRT detectable ctDNA had a significantly shorter PFS (p=0.012) and worse overall survival (OS) (p=0.004). Moreover, patients with high bTMB levels during CRT had prolonged OS (p=0.027). In conclusion, ctDNA and bTMB has the potential for predicting treatment efficacy and survival in ESCC treated with CRT and immunotherapy.
Contribution of mine-derived airborne particulate matter to Ca, Fe, Mn and S content and distribution in the lichen Punctelia hypoleucites transplanted to Bajo de la Alumbrera mine, Catamarca (Argentina)
Authors: Hernández Juan Martín , Cañas Martha Susana , Brizuela Luis German Rodríguez , Fournière Emmanuel Marie de la , Debray Mario Ernesto , Ramos Cinthia Paula , Plá Rita Rosa , Jasán Raquel Clara , Ivernizzi Rodrigo
Published: July 2023

The aim of this work is to relate the contribution of mine-derived airborne particulate matter to Ca, Fe, Mn and S content and distribution in Punctelia hypoleucites transplanted to Bajo de la Alumbrera, an important open-pit mine in Catamarca, Argentina. Lichen samples were transplanted to four monitoring sites: two sites inside the mine, and two sites outside the mine. After three months, elemental distribution in samples were analyzed by micro-Particle induced X-ray emission, and elemental concentration was determined by specific techniques: Ca and Fe by instrumental neutron activation analysis; Mn by inductively coupled plasma atomic emission spectrometry; S by a turbidimetric method. As a result, a differential distribution of S and Ca in thalli transplanted inside-mine sites was detected compared to that of samples transplanted outside-mine sites. An overlap of Fe and S in the upper cortex of the apothecium section was observed, leading to infer a mineral association of both elements. Similar association was observed for Ca and S. In addition to these results, the significantly higher concentration detected for S and Mn in inside-mine sites samples suggests a contribution of Fe, S, Ca and Mn of mining origin to the content and distribution of these elements in P. hypoleucites. Micro PIXE complemented with Mössbauer spectroscopy analysis determined the presence of pyrite particles together with other iron-bearing minerals with different degrees of oxidation were detected. These results point out to a mining origin of the airborne particulate matter trapped by the lichen thalli transplanted to Bajo de la Alumbrera.
Convergent evolution in Afrotheria and non-afrotherians demonstrates high evolvability of the mammalian inner ear
Authors: Grunstra Nicole , Hollinetz Fabian , Morante Guillermo Bravo , Zachos Frank , Pfaff Cathrin , Winkler Viola , Mitteröcker Philipp , Maitre Anne Le
Published: July 2023

Evolutionary convergence in distantly related species is among the most convincing evidence of adaptive evolution. The mammalian ear, responsible for balance and hearing, is not only characterised by its spectacular evolutionary incorporation of several bones of the jaw, it also varies considerably in shape across modern mammals. Using a new multivariate approach, we show that in Afrotheria, a monophyletic clade with morphologically and ecologically highly disparate species, inner ear shape evolved similar adaptations as in non-afrotherian mammals. We identified four trait combinations that underlie this convergence. The high evolvability of the mammalian ear is surprising: nowhere else in the skeleton are different functional units so close together; it includes the smallest bones of the skeleton, and is encapsulated within the densest bone. We suggest that this evolvability is a direct consequence of the increased genetic and developmental complexity of the mammalian ear compared to other vertebrates.
ReaxFF-nn: A Reactive Machine Learning Potential in GULP and the Applications in the Thermal Conductivity Calculation of Carbon Nanostructures
Authors: Guo Feng , Ye Zhong-Hao , Chai Chuan-Guo , Wen Yu-Shi
Published: July 2023

ReaxFF-nn stands for Reactive Force Field (ReaxFF) with neural networks and is currently added to the General Utility Lattice Program (GULP) by modern FORTRAN programming. With GULP and ReaxFF-nn with parameters that are trained by our I-ReaxFF package, the thermal properties, crystal properties, energy minimization, etc., can be done with precision at the quasi-density functional theory (DFT) level. Compared to other Machine Learning Potentials (MLPs), we do not construct a thoroughly new machine learning potential, but just simply used a small neural network for the bond order and bond energy calculations, and the uncorrected bond orders are chosen as the input atomic feature vector. The advantage of To validate the model which we have coded in the GULP, we compared the forces of a random structure between the auto-differentiate package and our FORTRAN code, and the difference between them is about 10-6. Furthermore, we provided a systematical study of the thermal conductivity (κ) of graphene and carbon nanotubes (CNTs) through the phonon Boltzmann transport equation. The value of κ thermal conductivity of graphene is very close to the DFT calculations. Therefore, we declare that the potential we have trained for sp2 carbon can reach the quasi-DFT level. In this work, we report the thermal conductivity of CNTs calculated by ReaxFF-nn at quasi-DFT level are range from 107.032 to 310.019 W.m-1.K-1.
Identification of PPAR β/δ agonists using a drug-repurposing approach by computational HTVS and molecular docking/ dynamics simulation
Authors: Mandal Sumit , Muzaffar-Ur-Rehman Mohammed , Puri Sonakshi , Kumar Banoth Karan , Sharma Pankaj Kumar , Sankaranarayanan Murugesan , Deepa P. R.
Published: July 2023

Peroxisome proliferator-activated receptors (PPARs) play a crucial role in regulating carbohydrate and lipid metabolism and are considered as significant targets for treating metabolic syndrome and cancers. There is a need to identify new bioactive ligands that can activate specific PPAR subtypes, particularly PPARβ/δ, which is less studied compared to other PPAR isoforms (α and γ). Here, the ZINC database of clinically approved drugs was screened to target PPARβ/δ receptor, through virtual screening followed by molecular docking and molecular dynamics (MD) simulation. Among the screened ligands, the top five ligands with strong binding affinity towards the PPARβ/δ were canagliflozin, empagliflozin, lumacaftor, eprosartan, dapagliflozin. The top-scoring ligands showed stable protein-ligand complexation (PLC)with PPARβ/δ, as revealed by RMSD / RMSF analysis. The in silico ADMET prediction analysis assessed the pharmacokinetic profiles of these top five ligands, wherein they showed favourable drug-likeness properties. These promising results indicate scope for developing and validating the top-scoring PPARβ/δ agonists in specific disease models.