bluuebunny/crossref_metadata_2025 huggingface dataset:
SG and SSR approach in the preparation of precursors and influence on superconducting properties of Tl-1223 superconductors
Authors: Metskhvarishvili Ioseb , LOBZHANIDZE T.E. , DGEBUADZE G.N. , BENDELIANI B.G. , METSKHVARISHVILI M.R. , RUSIA M.Sh. , GABUNIA V.M. , KOMAKHIDZE K.
Published: September 2020

The paper presents the comparative analysis of the Sol-gel (SG) and solid-state reaction (SSR) route for the synthesis of precursors for thallium-based superconductors. Samples were prepared a two-step method and by sealed quartz tube technique in ambient pressure. Heat treatments of precursors showed that to obtain high-purity precursors, without any carbonate contamination for SG methods is sufficient to heat treatments at 915oC temperatures and for SSR methods 945oC. The diamagnetic onset temperature of the superconducting transition for the TlBa2Ca2Cu3O8+δ samples prepared by precursors SG at 915oC and SSR at 945oC is about T = 120 K and full screening of applied ac magnetic fields observed at T ≈ 102 K and T ≈ 94 K, respectively. The value of Jc transport critical current densities for SSR obtained 128 A/cm2, whereas for the SG sample and exactly 174 A/cm2. We could conclude that the, using the wet chemistry offers some advantages in comparison with the classical solid-state ceramics processing, especially, better chemical homogeneity and higher reactivity of the precursor powder.
Embryos from "0PN" Zygotes May Be Most Likely 2PN Embryo in L-R-ICSI
Authors: Liu Caixia , Han Dong , Chen Jianguo , Liu Ying , Li Dong , Zhou Yan , Zhang Chaofan , Liu Jie
Published: September 2020

Although some zero pronuclei (0PN) zygotes cleave and develop into good embryos, they are usually discarded because they lack two distinct pronuclei (2PN). In this case report, we followed four couples to determine whether 0PN embryo could be used in late rescue intracytoplasmic sperm injection (L-R-ICSI). Here we report five healthy infants, including one set of twins, derived from "0PN" embryos from four frozen–warmed embryo transfer (FET) cycles in L-R-ICSI between 2015 and 2017. Of nine infants born from L-R-ICSI cycles in our center, five were "0PN" embryos, and all remain healthy. Embryos from "0PNs" such as 2PN can develop into healthy babies using L-R-ICSI. This finding suggests that embryos from "0PNs" in L-R-ICSI may be different from traditional 0PN gametes and more likely to originate from 2PN gametes and they may be used in those infertile couples who lack 2PN embryos, instead of discarding them. The use of "0PN" embryos increases the cycles reaching embryo transfer, allowing some infertile couples to have healthy children and to avoid mental anguish and wasted time and money.
Global Research on DNA methylation from 2000 to 2019: Bibliometric Analysis and Visualization
Authors: Su Xuan , Weng Lin-Man , Zheng Kang-Yong , Wang Xue-Qiang
Published: September 2020

Introduction:DNA methylation is the most common epigenetic feature in human somatic cells, it has played a crucial role in regulating related genes and diagnosing cancer. However, few studies used bibliometric method to systematically analyze the development of DNA methylation. The purpose of this study was to systematically analyze the trends of DNA methylation research from 2000 to 2019. Methods:The published studies were searched between January, 2000 and December 31st, 2019 in the Web of Science. We only included peer-reviewed reviews and articles. The language was limited to English, and no species limitations were specified. A total of 11,127 publications met the inclusion criteria. CiteSpace V was used to analyze the trends of DNA methylation research. Results:The results showed the publications had a statistical increase over time in the DNA methylation research(P<0.005) by linear regression analyses. USA had the largest number of published papers (4263). Plos One contributed to the most publications (4.52%). The most prolific institution is Chinese Acad Sci (237). In accordance with subject categories of Web of Science, Genetics Heredity subject category had the largest number of publications (2,516) and citations (119,113). Biochemistry Molecular Biology subject category had the highest number of H-index (154). On the basis of the co-citation map of references, the “specific dna methylation” was labeled as the largest cluster. Most recent burst keywords were as follows: “pregnancy” (2017~2019), “obesity” (2017~2019), “growth” (2017~2019). Conclusions: This study provides useful information for DNA methylation researchers to find fresh viewpoints related to collaborators, cooperative institutions, popular topics. It also reminds us to pay attention to some new research trends.
Specific pathogens indicate higher risk of polymicrobial periprosthetic joint infection: a single-center retrospective study
Authors: Li Hao , Jiang Qiao , Chen Jiying
Published: September 2020

Background

Polymicrobial periprosthetic joint infection is a subset of periprosthetic joint infection and indicates disastrous outcomes. However, the incidence of polymicrobial PJI can be underestimated so we perform a single-center retrospective study with an intention to predict the incidence of polymicrobial PJI based on culture results.
Materials and methods

Medical records about 153 patients with PJI between 2017/1/1 and 2018/12/31 in a joint center were selected retrospectively. Multivariable analysis was utilized to evaluate the association between various pathogens and polymicrobial PJI.
Result

Staphylococcus aureus (OR:3.83, 95%CI(1.30,11.27), p-value = 0.015 ), coagulase negative staphylococci (OR: 2.68 ,95%CI: (1.10, 6.25), p-value = 0.028), Enterococcus spp (OR:6.46;95%CI(1.35,30.87),P-value = 0.020)andStreptococcusspp(OR:19.38, 95%CI:(3.57,105.21), p-value = 0.001) indicate higher risk of polymicrobial pathogens compared with other pathogens
Conclusion

Streptococcus spp and Enterococcus spp are associated with higher risk of polymicrobial PJI and more pathogens are like to be found in additional culture when these pathogens are detected by a single culture.
A Modified Method to Determine the Humerus Height and Humeral Head Retroversion for Hemiarthroplasty
Authors: Wei Wanfu , Li Jian`an , Bu Guoyun , Yang Tao
Published: September 2020

Background Placement of shoulder prosthesis used for reconstruction of a complex proximal humerus fractures is critical because it is related to clinical outcomes after hemiarthroplasty. To achieve the anatomical placement of the prosthesis, we introduced a simple operative method to determine the humerus height and humeral head retroversion, and retrospectively investigated the clinical and radiographic outcomes of our procedure.Method 34 patients, treated by shoulder arthroplasty for 4-part or 3–part proximal humeral fracture during the period between June 2016 and December 2018, were enrolled in the study. Eventually 29 patients, 18 women and 11 men with an average age of 68.4 years (range 58-85 years), were followed up successfully. Of which 13 patients treated with classic method were matched to 19 of the 29 new method treated patients by operation time, blood loss, pain, range of motion, Constant-Murley score and radiographic features. Results There was a significant difference between the two treatment groups in operation time (p=0.024), while there was no significant difference in blood loss (p=0.078). No significant difference was found between the two treatment groups in Visual Analog scale (p=0.225), Constant-Murley score (p=0.930), and radiological outcomes (p=0.504). There was linear regression and correlation between Constant-Murley score and age (p=0.027), while there was no linear relationship between status of tuberosity and the function of the shoulder joint (p=0.931). Conclusion We introduce a new operative technique to determine the humerus height and humeral head retroversion for shoulder arthroplasty operation. Based on the data, there is linear regression and correlation between Constant-Murley score and age, while there is no linear relationship between status of tuberosity and the function of the shoulder joint. Our present analyses reveal that our protocol is personalized, easy, effective and feasible.Trial registration: https://doi.org/10.1186/ISRCTN28175069.
Incidence and Predictors of Diabetes Mellitus And Outcome of Pre-Diabetes: A Prospective, Community-Based Cohort Follow-Up Study
Authors: Silva Shamila Thivanshi De , Ediriweera Dileepa , Niriella Madunil Anuk , Beddage Thulani , Kasturiratne Anuradhani , Pathmeswaran Arunasalam , Kato Norihiro , Wickramasinghe Rajitha , Silva H Janaka de
Published: September 2020

BackgroundThere is limited data on prevalence and outcome of prediabetes (PDM) and incidence of type 2 diabetes mellitus (T2DM) from South Asia. We investigated this in an urban, adult population in Sri Lanka that was followed-up for seven years. Methods The study population (selected by age-stratified random sampling from the community) was initially screened in 2007 and re-evaluated in 2014. On both occasions they were assessed by structured interview, anthropometric measurements, liver ultrasound, biochemical and serological tests. Results In the original cohort of 2985 recruited in 2007 [54.8% women, median age (IQR) 53 (47-59)], 737 had T2DM [baseline prevalence 24.7% (95% CI: 23.1–26.2)] and 525 (17.7%) had PDM [54.1% women, median age (IQR) 56 (50-60)]. 2148/2985 (71.6%) attended follow-up in 2014 [57.5% women; median (IQR) 60 (54–66) years], which included 1650 who did not have T2DM in 2007. By 2014, 436/1650 (27.6%) had developed new T2DM [annual incidence 3.9% (95% CI:3.0-4.9). On logistic regression, PDM, central obesity, dyslipidemia and non-alcoholic fatty liver disease (NAFLD) showed significant association with incident T2DM. Of 525 with PDM in 2007, 365 (69.5%) presented for follow up in 2014; 147 (40.3%) remained in PDM, 201 (55.1%) had progressed to T2DM and 17 (4.6%) had reverted to normal. Annual conversion rate of PDM to T2DM was 7.9%. Increase in waist circumference and decrease in HDL predicted progression to T2DM. ConclusionsPresence of components of the metabolic syndrome at baseline predicted new-onset T2DM and conversion of PDM to T2DM. Targeted lifestyle interventions are essential for individuals with metabolic risk to prevent incident T2DM.
Co-evolution of COVID-19 Research and China’s Policies
Authors: Xi Cheng , Li Tang , Maotian Zhou , Guoyan Wang
Published: September 2020

The dynamics of research are a prism that reflects interactions between science, the societal environment, and government policies. Against the backdrop of the ongoing global COVID-19 pandemic, this study explored the changes in, and development of, COVID-19 research in the period from December 30, 2019 to April 27, 2020. The study observes a salient change in research content: an earlier focus on “all patients”, “common symptoms”, and “nucleic acid test” was gradually replaced by a focus on “children”, “pregnant patients”, “severe symptoms”, and a combination of “nucleic acid test” and “antibody assay”. Some topics such as “vaccine R&D”, “knowledge, attitude, and practice” (KAP), and “mental health” were persistent throughout the recent history of China’s COVID-19 research. This study also reveals a correlation between the evolution of COVID-19 policies and the dynamic development of COVID-19 research. In the early stage of the outbreak in China, the formulation of COVID-19 policies followed a rapidly-progressing co-evolutionary model (CEM). The results of this study apply more broadly to the formulation of policies in public health emergencies, especially in the early stages.
Long Wavelength Single Photon Like Driven Photolysis Via Triplet-Triplet Annihilation
Authors: Han Gang , Huang Ling , Zeng Le , Chen Yongzhi , Yu Nuo , Wang Lei , Huang Kai , Zhao Yang
Published: September 2020

Photolysis has enabled the occurrence of numerous discoveries in chemistry, drug discovery and biology. However, there is a dearth of efficient long wavelength light mediated photolysis. Here, we report general and efficient long wavelength single photon method for a wide array of photolytic molecules via triplet-triplet annihilation photolysis (TTAP). This method is versatile and "LEGO"-like. The light partners (the photosensitizers and the photolytic molecules (PPG-Xs)) can be energetically matched to adapt to an extensive range of electromagnetic spectrum wavelengths and the diversified chemical structures of photoremovable protecting groups (PPGs), photolabile linkages, as well as a broad array of targeted molecules. Our TTAP not only surpasses reaction yields, it also resolves the photodamage problem of the existing photolysis methods, regardless of whether they are a single photon or multiple photons associated. Furthermore, we developed ambient air-stable, TTAP nanoparticles to illustrate the biological promise of TTAP “LEGO” systems.
High carrier prevalence with poor knowledge of thalassaemia among the university students from indigenous communities in Bangladesh
Authors: Hasan Md. Mahbub , U Khaza Md. Kapil , Lokman Syed Mohammad , Mannan Adnan , Raheem Enayetur , Chowdhury Shahed Ahmad , Hossain Mohammad Sorowar
Published: September 2020

Background

Thalassemia is an inherited life-threatening but preventable haemoglobin disorder. South Asian countries including Bangladesh are the hotspots of world’s thalassemia belt. Indigenous communities are underprivileged and vulnerable to genetic disorders including thalassaemia. Understanding the perspectives of thalassemia of the future community leaders (indigenous university students) is critical for developing a tailor-made preventive strategy relevant to their communities. In this study, we aimed to assess the level of knowledge and attitudes towards thalassaemia among indigenous university students and determine their thalassemia carrier status.
Methods

A cross-sectional survey was conducted among 251 tribal university students using a published questionnaire between May and October 2018. Half of the students underwent thalassemia carrier screening by haemoglobin electrophoresis. Descriptive and inferential statistical procedures were used for data analysis.
Results

More than half (55%) of the indigenous students had never heard the term 'thalassaemia'. Around half of the marriages in their communities were consanguineous. The mean knowledge score was very poor (4.91 ± 2.65) which was not associated study disciplines, and year of study. Nearly 39% of the students were found to be the carrier of E trait, while 1.8% of them had beta trait and 7% E disease. Thalassaemia carrier status was not significantly correlated with sex, ethnicity, or home districts.
Conclusions

For the first time, this study has identified knowledge gaps and misperceptions about thalassaemia among university students from indigenous communities with a higher prevalence of thalassaemia. This study serves as a baseline for future interventions (premarital and prenatal screening) targeting future community leaders.
Ligand Based 3D-QSAR Pharmacophore, Molecular Docking and Adme to Identify Potential Fibroblast Growth Factor Receptor 1 Inhibitors 
Authors: Tang Zizhong , Huang Lu , Fu Xiaoli , Wang Haoxiang , Tang Biao , Xiao Yirong , Zhou Caixia , Zhao Zhiqiao , Wan Yujun , Chen Hui , Yao Huipeng , Shan Zhi , Bu Tongliang , Wu Xulong
Published: September 2020

The FGF/FGFR system may affect tumor cells and stromal microenvironment through autocrine and paracrine stimulation, thereby significantly promoting oncogene transformation and tumor growth. Abnormal expression of FGFR1 in cells is considered to be the main cause of tumorigenesis and a potential target for the treatment of cancer. In this study, a combination of structure-based drug carriers and molecular docking-based virtual screening was used to screen new potential FGFR1 inhibitors. Twenty-one known inhibitors were collected as training sets to establish a 3D-QSAR pharmacophore model, and cost analysis, test set validation, and Fischer randomization test were used to validate the efficiency of the pharmacophore model. In Accelrys Discovery Studio 2016, the zinc database was filtered by Lipinski's Rule of Five and SMART's filtration. Then, Hypo01 was used for virtual screening of ZINC database. Compounds with predicted activity values less than 1 μM were molecularly docked with FGFR1 protein crystals, the docking results were observed, and the interaction between compounds and targets was studied. The absorption, distribution, metabolism and excretion (ADME) and toxicity of potential inhibitors were studied, and a compound with new structural scaffolds were obtained. It could be further studied to explore their better therapeutic effects.
Prevalence and Factors Associated With Anemia Among Pregnant Women Attending AMDA Hospital of Eastern Nepal
Authors: Acharya Gaurab , Sirichokchatchawan Wandee , Sanjel Keshab
Published: September 2020

BackgroundAnemia is a global public health problem, consisting 40% of pregnant women being anemic worldwide. Manifold factors directly or indirectly contribute to anemia during pregnancy and amplify the risk of maternal and fetal mortality and morbidity. However, factors associated with anemia among pregnant women are not broadly understood in sub-national level. Thus, this study has made an effort to ascertain the prevalence and associated factors of anemia among pregnant women in AMDA Hospital of Eastern Nepal. MethodsHealth-facility based cross-sectional study was conducted among pregnant women of age 18-49 years attending antenatal care (ANC) in AMDA Hospital. A total of 420 samples were recruited through systematic random sampling. Data was collected through a validated semi-structured questionnaire. Hemoglobin concentration was recorded from laboratory test report. Collected data were entered in EpiData and analyzed in SPSS Version 22 licensed by Chulalongkorn University. Chi-square test was used for bivariate analysis and later, significant variables at p-value<0.10 were processed on multivariate analysis. Finally, the adjusted odd ratio was reported considering significant at p-value <0.05 with 95% confidence interval. ResultsThe overall prevalence of anemia was 42.1% (37.4%–47.0%). Almost 46%, 41% and 14% of women were with mild, moderate and severe types respectively. Factors such as age less than 20 years (7.23, 2.50–20.87) and between 20- 24 years (2.80, 1.31–5.96), religious minorities (3.09, 1.35–7.06), vegetarian diet pattern (4.33, 1.49–12.59), inadequate frequency (DGLV: once a week, fruits: twice in a week) of eating DGLV (8.71, 2.26 – 33.63) and fruits (2.73, 1.41–2.29), inadequate dietary diversity (7.16, 3.15–16.27), as well as no intake of multivitamins during pregnancy (4.23, 1.49– 11.98) were statistically associated with anemia among pregnant women. ConclusionOverall, the prevalence of anemia was found to be high in the study area. The associated factors of anemia ranged from socio-economic, dietary and obstetric care, and included age, religion, diet pattern, and frequency of eating DGLV and fruits, dietary diversity, as well as intake of multivitamins during pregnancy. The study recommends enhancing community-based interventions considering the identified factors.
Seismic Vulnerability Assessment using Numerical Simulation for a Residential Buildings – A Case study
Authors: Mehjebin Jennifer , A.S Santhi , Ganapathy Ganapathy Pattukandan
Published: September 2020

Seismic vulnerability assessment of an existing building is of high importance for ensuring the safety of the structure and the occupants. An earthquake may not be predictable but seismic performance of a structure can be well- predicted in advance which aids in deciding the correct retrofit technique for a building ensuring the safety of the occupants. A RC building situated in the seismic zone III region of Vellore, Tamil Nadu has been taken into consideration for analysing its seismic vulnerability. The region is yet to catch engineering attention for evaluation of seismic performance of such buildings. With the help of the nearest fault line data, the PGA value was calculated and the value suggested moderate potential damage. The RVS score of the building was categorised in the high probability of Grade Damage 3 i.e. structural damage in moderate range and non-structural damage in heavy range. A detailed numerical analysis was carried out in ETABS using equivalent static force method to simulate the earthquake forces in the structure. Although a dynamic method of analysis considers higher magnitude of earthquake forces based on a more realistic earthquake excitation, equivalent static force analysis is sufficient for a preliminary analysis of the building. The building having a soft storey in the ground floor showed variations in its behaviour on application of earthquake forces in four different case scenarios of shear wall application. The maximum storey drifts were then compared for the building in cases of existing soft storey and with the application of shear wall in the ground floor, staircase walls and with a combination of shear wall in both the locations. The results showed that shear wall in the staircase proved to be the most economical retrofit solution for the building.
A Novel Four-MicroRNA Signature for Prognosis and Diagnosis in Colorectal Cancer
Authors: Chen Yan , Qin Ying , Zhou Yaoyao , Dai Mengmeng , Sun Qinsheng , Li Lulu , Qiu Cheng , Jiang Yuyang
Published: September 2020

Background and aims: Colorectal cancer (CRC) remains a global public health problem. We aimed to access prognostic microRNAs (miRNAs) associated with overall survival (OS) and evaluate their diagnostic value in CRC.Methods: Three serum miRNA expression profiles from Gene Expression Omnibus (GEO) database and tissue miRNA expression profile of CRC from The Cancer Genome Atlas (TCGA) database were studied to get common differentially expressed miRNA (DEmiRNAs) in serums and tissues. 569 CRC patients with survival information from TCGA database were randomly divided into the discovery and validation cohort. Based on the TCGA discovery cohort, the univariate cox analysis, least absolute shrinkage and selection operator (LASSO) regression analysis and multivariate cox proportional hazards regression analysis were performed and a prognostic signature was constructed. The prognostic capacity of the signature was verified in TCGA validation cohort and the prognostic signature expression in tumors and serums was validated in an independent microarray dataset and our clinical set. We also evaluated the diagnostic power of the model in serum by calculating the area under the receiver operating characteristic (ROC) curve in a clinical set. Functional enrichment analyses were applied to analyze the potential roles of the signature in CRC.Results: A total of 154 common DEmiRNAs were identified. Based on the TCGA discovery cohort, a four-miRNA (miR-10b, miR-130a, miR-561, miR-4684) prognostic signature was constructed and a predictive nomogram model including the expression of above four miRNAs showed good performance for predicting the 3- and 5-year overall survival. The findings were well verified in TCGA validation cohort. miR-10b, miR-130a, miR-561 and miR-4684 were significantly upregulated both in CRC tumors and serums. Circulating miR-10b, miR-130a, miR-561 and miR-4684 levels were significantly downregulated after surgical resection of tumor in CRC patients, suggesting these four circulating miRNAs in the serum were tumor derived. The four circulating miRNA combination might act as a novel diagnostic signature for CRC. Functional enrichment analyses suggested that above four miRNAs might be related to the progression of CRC. Conclusions: We developed a novel reliable prognostic and diagnostic signature, which should be beneficial for CRC screening and clinical therapeutic decision-making.
Development and Validation of A Seven-microRNA Signature as a Novel Prognostic Biomarker for Bladder Cancer
Authors: Lv Jin-Xing , Lin Fei , Ke Zhi-Bin , Lin Yun-Zhi , Zhuang Peng-Fei , Chen Ye-Hui , Chen Shao-Hao , Xue Xue-Yi , Zheng Qing-Shui , Wei Yong , Xu Ning
Published: September 2020

Background The differential expression of miRNAs has played a significant role in bladder tumors. The aim of our study was to screen new biomarkers . Methods Through differential analysis of bladder cancer mRNA and miRNA expression data in the TCGA, differential genes and miRNAs were screened. Furthermore, Cox univariate analysis and multifactor analysis were used to establish a prognostic prediction model . The predictive ability of the prognostic model was then verified on the patient. The action mechanism of these miRNAs was analyzed.Results By the differential analysis and standardization of miRNA expression profiles. Differentially expressed miRNAs were screened, then all the patients were then randomly divided into train group and the test group. 23 miRNAs were revealed , then a Seven-miRNA signature prognostic biomarkers was constituting.Univariate cox regression and multivariate cox regression considering other clinical factors displayed that the seven-miRNA signature could serve as an independent prognostic factor.Target genes of these seven miRNAs were analyzed by KEGG signaling pathway and GO enrichment analysis. . Conclusion The prognostic model constructed by seven miRNAs has possessed certain degree of sensitivity and specificity for the prediction of the survival of bladder cancer patients, which can be used as a potential new clinical marker for bladder cancer patients.
A Teoria da Aprendizagem Significativa e o jogo
Authors: Do Espirito Santo Silva-Pires Felipe , Da Silva Trajano Valéria , Cremonini de Araujo-Jorge Tania
Published: September 2020

O jogo faz parte da história da humanidade e seu potencial como facilitador dos processos de ensino e de aprendizagem está associado ao uso de uma linguagem clara e objetiva. O jogo promove o compartilhamento e negociação de significados, de forma não-arbitrária e substantiva, possibilitando uma Aprendizagem Significativa, que ocorre quando há associação entre o conhecimento prévio do indivíduo com um material potencialmente significativo, como ideias ou conceitos. O propósito deste trabalho é apresentar os princípios da Teoria da Aprendizagem Significativa e o conceito e as propriedades do jogo, e discutir como ambos interagem. Acreditamos que a Teoria se configura como referencial teórico-metodológico para a construção de recursos didáticos capazes de facilitar os processos de ensino e de aprendizagem, e que o jogo se destaca como material educacional ao promover o desenvolvimento cognitivo, afetivo e motor por meio da integração entre professor-aluno-conteúdo.
A pedagogia como alicerce da teoria política em Rousseau
Authors: Calil Breymaier Sophia , Boto Carlota
Published: September 2020

O presente artigo procura - através de uma análise crítica e explicativa, baseada em estudos de bibliografia das obras de Rousseau, centrando-se principalmente nos Discursos e em Emílio - evidenciar de que maneira o conceito de natureza, na perspectiva da teoria política e social desenvolvida por Rousseau, se coaduna com aquele  expresso em sua obra pedagógica Propõe-se a investigar  as bases filosóficas do pensamento rousseauniano para analisar o conceito de natureza e o homem, articulando-o com o modo pelo qual outros autores contratualistas  pensaram o mesmo problema. Busca por fim expor uma possível unidade no pensamento político e pedagógico de Rousseau, para desenvolver, à luz de suas ideias, a construção de uma teoria acerca dos fundamentos da sociedade e do direito natural, bem como de um projeto de pedagogia natural e moral para que fosse possível estabelecer a vontade geral.
Pornodyssey
Authors: Cooper Jennifer Sarah
Published: September 2020

The celebrated novel Pornopopéia, by Reinaldo Moraes, represents a type of joycean Ulysses of the city of São Paulo’s underground in the excesses of the 1980s extended to the beginning of the 21st century. Despite its importance in contemporary Brazilian literature and perhaps because of its literary and linguistic complexity in producing its distinct humor, it has never before been translated into English. This article reports some results of a post-doctoral research in which we carried out a literary, commented translation of this epic novel. The theoretical framework of the research was based in general on a model of language from the perspective of the Theory of Genre and Register (TGR) (MARTIN; ROSE, 2008) and on Berman’s concept of ‘tradutology’ (2012), while the translation practice was informed by adaptations of Rothenberg’s concept of ‘total translation’ (2010), Frota’s Jazz Theory (1989), Toury’s ‘norms’ (1995), Milton’s (1998) discussion of metaphors for the practice of translation. Some results point to the following features as contributing to humor and presenting distinct challenges in the process of translating them:  code-mixing and switching, punning haiku, rapid changes in registers from erudite to street, sonority (hard rhymes), neologisms, blends, and other linguistic, semantic and generic transgressions, along with those of a social nature. Ultimately, with this research we hope to offer the anglophone reader the pleasure of this text by Reinaldo Moraes, simultaneously disseminating Brazilian literature and culture to a broad anglophone speech community through the translation, and ultimately contributing to reflections on the practice of translation in translation studies.
Seeking to Engage
Authors: Maser Michael
Published: September 2020

Simon Fraser University, from the time of its opening in the 1960s, has striven to be a modernist and progressive educational institution. These characteristics are reflected in the architectural designs of its campuses, its epistemological orientations and offerings, and its policies. The university also states an ambition to be "Canada's most engaged university" on its website (sfu.ca/about.html). It is in considering this last point that this paper questions and considers SFU's 'engagement' in the context of the emerging environmental crisis. In particular, this paper focuses attention on the Burnaby Mountain campus and considers its place - geographically, architecturally, and culturally, and how these considerations of place intertwine and contribute or detract from a sense of engagement. Overall, this author posits that Simon Fraser's Burnaby Mountain campus is critically alienated from the in-situ forest that surrounds it, through character and gesture, and this is most unfortunate given a stated need by experts and educators to deepen engagement with natural environments in this time of crisis. Insights from place-based education identify that in-situ ecological knowledge, and insights arising from First Nations peoples, can help to grow new knowledge and awareness, deepen resiliency, and affect positive cultural change. The author suggests that Simon Fraser's Burnaby Mountain campus is an appropriate location to grow such a place-based education program and deepen its engagement in new, valuable ways.
Xigua Video as a Source of Information on Breast Cancer: Content Analysis
Authors: Pan Peng , Yu Changhua , Li Tao , Zhou Xilei , Dai Tingting , Tian Hanhan , Xiong Yaozu
Published: September 2020

Background

Seeking health information on the internet is a popular trend. Xigua Video, a short video platform in China, ranks among the most accessed websites in the country and hosts an increasing number of videos with medical information. However, the nature of these videos is frequently unscientific, misleading, or even harmful.

Objective

Little is known about Xigua Video as a source of information on breast cancer. Thus, the study aimed to investigate the contents, quality, and reliability of breast cancer–related content on Xigua Video.

Methods

On February 4, 2020, a Xigua Video search was performed using the keyword “breast cancer.” Videos were categorized by 2 doctors based on whether the video content provided useful or misleading information. Furthermore, the reliability and quality of the videos were assessed using the 5-point DISCERN tool and 5-point global quality score criteria.

Results

Out of the 170 videos selected for the study, 64 (37.6%) were classified as useful, whereas 106 (62.4%) provided misleading information. A total of 41.8% videos (71/170) were generated by individuals compared to 19.4% videos (33/170) contributed by health care professionals. The topics mainly covered etiology, anatomy, symptoms, preventions, treatments, and prognosis. The top topic was “treatments” (119/170, 70%). The reliability scores and global quality scores of the videos in the useful information group were high (P<.001). No differences were observed between the 2 groups in terms of video length, duration in months, and comments. The number of total views was higher for the misleading information group (819,478.5 vs 647,940) but did not reach a level of statistical significance (P=.112). The uploading sources of the videos were mainly health care professionals, health information websites, medical advertisements, and individuals. Statistical differences were found between the uploading source groups in terms of reliability scores and global quality scores (P<.001). In terms of total views, video length, duration, and comments, no statistical differences were indicated among the said groups. However, a statistical difference was noted between the useful and misleading information video groups with respect to the uploading sources (P<.001).

Conclusions

A large number of Xigua videos pertaining to breast cancer contain misleading information. There is a need for accurate health information to be provided on Xigua Video and other social media; health care professionals should address this challenge.
The Genetic Base For Drug Addiction (Preprint)
Authors: Nasih Srwsh
Published: September 2020

BACKGROUND

Objective: There are many evidences about relationship between eating behavior and drug addiction. A number of susceptibility loci that point to shared higher order genetic pathways underling addiction were found in genetic studies. This study assumed that a genome-wide association study (GWAS) of food addiction would produce important enrichment in genes and pathways related to addiction.

OBJECTIVE

Objective: There are many evidences about relationship between eating behavior and drug addiction. A number of susceptibility loci that point to shared higher order genetic pathways underling addiction were found in genetic studies. This study assumed that a genome-wide association study (GWAS) of food addiction would produce important enrichment in genes and pathways related to addiction.

METHODS

Methods: This study done among 314 women of European ancestry, by using a GWAS of food addiction, which is determined by the modified Yale Food Addiction Scale (mYFAS). Results for enrichment of single nucleotide polymorphisms (SNPs) (n 5 44), genes (n 5 238), and pathways (n 5 11) involved in drug addiction were tested.

RESULTS

Results: Two loci met GW-significance (P < 2.5 10 -8) with no obvious roles in eating behavior, they are mapping to 17q21.31 and 11q13.4. GW results were significantly enriched for gene members of the MAPK signaling pathway (P = 0.02). After adjustment for multiple testing, candidate SNP or gene for drug addiction was not linked with food addiction.

CONCLUSIONS

Conclusions: limited support was delivered for shared genetic underpinnings of drug addiction and food addiction, although the GWAS of mYFAS, need further investigation and follow up.
Keywords: gene, food, addiction
Evaluation of the Acceptability of a Proposed, Instagram-Based, Randomized Controlled Trial for People With Asthma: Survey Study (Preprint)
Authors: Spitzer Kerry A , Heineman Brent , Jewell Marcella , Moran Michael , Lindenauer Peter K
Published: September 2020

BACKGROUND

Asthma is a chronic lung disease that affects nearly 25 million individuals in the United States. More research is needed into the potential for health care providers to leverage existing social media platforms to improve healthy behaviors and support individuals living with chronic health conditions.

OBJECTIVE

In this study, we assessed the willingness of Instagram users with poorly controlled asthma to participate in a pilot randomized controlled trial that will use Instagram as a means of providing social and informational support. In addition, we explored the potential for adapting the principles of photovoice and digital storytelling to Instagram.

METHODS

We conducted a survey study of Instagram users aged 18-40 years with poorly controlled asthma in the United States.

RESULTS

Over 3 weeks of recruitment, 457 individuals completed the presurvey screener; 347 (75.9%) were excluded and 110 (24.1%) were eligible and agreed to participate in the study. Of the 110 individuals, 82 (74.5%) completed the study survey. The mean age of the respondents was 21 (SD 5.3) years. Among respondents, 56% (46/82) were female, 65% (53/82) were non-Hispanic White, and 72% (59/82) had at least some college education. The majority of respondents (67/82, 82%) indicated that they would be willing to participate in the proposed study.

CONCLUSIONS

Among young adult Instagram users with asthma, there is substantial interest in participating in a pilot randomized controlled trial that will use Instagram to connect participants with peers and a health coach to share information about self-management of asthma and build social connection.
Medical profile suitable to practice through Telemedicine with efficacy and safety: Survey (Preprint)
Authors: Escobar-Curbelo Sr Luis , Franco – Moreno Anabel I. , Montero Hernandez Carmen , Muriel Alfonso
Published: September 2020

BACKGROUND

To perform telemedicine correctly, thus improving the healthcare of our patients and saving resources, we need to differentiate between three pillars: A healthcare professional with a suitable profile to practice Telemedicine, a patient with a profile suitable for being attended to through Telemedicine, and a clinical case at an optimal time of the disease to benefit from Telemedicine.

OBJECTIVE

The objectives of this study were to find out the number of face-to-face consultations that could be solved with the same efficacy and safety through telemedicine and to define the most suitable doctor profile to practice teleconsultation.

METHODS

This is a prospective, descriptive, non-probabilistic and random sampling study using an uncontrolled selection process of a 22-question survey of doctors from the Spanish health service, which analyses the number of medical consultations that could be carried out through telemedicine based on the question: “Approximately, out of every 10 medical consultations you perform, how many of the regular consultations could have been resolved without the need for in-person visits, with the same efficacy and safety? (Telephone, video call, chat, etc.)”.

RESULTS

The 76 doctors who answered the questionnaire believed that 43% of face-to-face consultations could have been resolved with the same efficacy and safety through telemedicine. The variables that were associated with having a suitable medical profile for teleconsultation were whether the doctor was willing to try telemedicine (OR = 2.01 95% CI 1.23, 3.30) and whether many consultations with physical examination were required (OR = 0.7 95% CI 0.57, 0.91).

CONCLUSIONS

The doctors believed that almost half of their face-to-face consultations could have been resolved with the same efficacy and safety through telemedicine. A suitable doctor profile to conduct teleconsultations was someone who was willing to try telemedicine and rarely needed to perform physical patient examinations in their face-to-face consultations.
Obesity and BMI Cut Points for Associated Comorbidities: Electronic Health Record Study (Preprint)
Authors: Liu Natalie , Birstler Jen , Venkatesh Manasa , Hanrahan Lawrence , Chen Guanhua , Funk Luke
Published: September 2020

BACKGROUND

Studies have found associations between increasing BMIs and the development of various chronic health conditions. The BMI cut points, or thresholds beyond which comorbidity incidence can be accurately detected, are unknown.

OBJECTIVE

The aim of this study is to identify whether BMI cut points exist for 11 obesity-related comorbidities.

METHODS

US adults aged 18-75 years who had ≥3 health care visits at an academic medical center from 2008 to 2016 were identified from eHealth records. Pregnant patients, patients with cancer, and patients who had undergone bariatric surgery were excluded. Quantile regression, with BMI as the outcome, was used to evaluate the associations between BMI and disease incidence. A comorbidity was determined to have a cut point if the area under the receiver operating curve was >0.6. The cut point was defined as the BMI value that maximized the Youden index.

RESULTS

We included 243,332 patients in the study cohort. The mean age and BMI were 46.8 (SD 15.3) years and 29.1 kg/m2, respectively. We found statistically significant associations between increasing BMIs and the incidence of all comorbidities except anxiety and cerebrovascular disease. Cut points were identified for hyperlipidemia (27.1 kg/m2), coronary artery disease (27.7 kg/m2), hypertension (28.4 kg/m2), osteoarthritis (28.7 kg/m2), obstructive sleep apnea (30.1 kg/m2), and type 2 diabetes (30.9 kg/m2).

CONCLUSIONS

The BMI cut points that accurately predicted the risks of developing 6 obesity-related comorbidities occurred when patients were overweight or barely met the criteria for class 1 obesity. Further studies using national, longitudinal data are needed to determine whether screening guidelines for appropriate comorbidities may need to be revised.
Differences in Health Access and Disparities between Phone and Video-based Virtual Care: A Cross Sectional Study (Preprint)
Authors: Khairat Saif , John Roshan , Pillai Malvika , Edson Barbara , Gianforcaro Robert
Published: September 2020

BACKGROUND

Health systems have rapidly adopted telehealth as an alternative healthcare delivery mode in response to the Covid-19 pandemic.

OBJECTIVE

The objective of this study was to compare the effectiveness of telemedicine modalities namely, phone and video, on health access, disparities, and service outcomes.

METHODS

We conducted a cross-sectional study of outpatients with telemedicine visits using a state-wide, on-demand telehealth service. Virtual Urgent Care (VUC) clinic data was collected from March 3rd, 2020 through May 3rd, 2020 using the institutional data warehouse.

RESULTS

Of 1803 telemedicine visits, 1278 (70.9%) were of patients who were female, 730 (40.5%) were of ages 18-34, 1423 (78.9%) were uninsured. Significant relationships between telemedicine modalities and gender (p-value=0.0002), age (p-value<0.0001), insurance status (p-value<0.0001) health access (p-value = 0.0094), and prescriptions given (p-value < 0.0001). Phone visits provided significantly more access to rural areas than video visits (p<0.01). Of all rural visits, 170 (68%) were from phone visits and 80(32%) were video visits. Significant differences were found in medication prescription rates between phone and video visits (p<0.01), visit wait times (p<0.0001), and visit duration (p<0.0001).

CONCLUSIONS

We found that the combination of phone and video visits meet the needs of various vulnerable populations, and has substantial effect on improving access, reducing disparities while maintaining high quality telemedicine services. To improve the adoption rates and quality of telemedicine visits, more work is needed in building internet capacity within our rural communities, increasing awareness among patients to choose the correct telemedicine modality, and creating policies to ensure fairness in service outcomes between phone and video visits.
The impact of confinement and other stressors during the COVID-19 pandemic on depression and anxiety in the Lebanese context: an online cross-sectional survey (Preprint)
Authors: Khalil Rami , Dagher Ramez , Zarzour Myriam , Abi-Akl Hanna , Sleilaty Ghassan , Kallab Maya , Richa Sami
Published: September 2020

BACKGROUND

Confinement measures were taken since February 2020 in Lebanon, a country already going through a socio-economic crisis, to fight the new coronavirus pandemic.

OBJECTIVE

The aim of this study is to evaluate the psychological impact of the confinement in this country.

METHODS

A cross-sectional, online survey, was conducted during the confinement period in order to assess depression and anxiety symptoms as well as eating and substance use disorders using self-rating scales (the DASS-21, SCOFF and CAGE-AID respectively), while identifying factors that might affect those outcomes.

RESULTS

Overall, 1133 participants completed the questionnaire. The DASS-21 score was positively correlated with the impact of confinement on participants’ lifestyle and confinement duration (Spearman’s rho= 0.424; p<0.001). A highest effect on DASS-21 score was related to the intensity of other stressful life events that have happened during the last 3 months (Spearman’s rho= 0.506; p<0.001). Linear regression analysis also showed that age, monthly income, professional status, the SCOFF and CAGE-AID scores, the intensity of the confinement’s impact on lifestyle and having been through other stressful life events unrelated to the confinement per se, were risk factors affecting significantly the DASS-21 score.

CONCLUSIONS

Confinement in the context of the COVID-19 pandemic in Lebanon, as well as other stressful life event that have happened during the last 3 months, were associated with higher depression, anxiety, and stress symptoms.

CLINICALTRIAL

LBCTR2020043459
Authors’ Reply to: Comment on “Facebook as a Novel Tool for Continuous Professional Education on Dementia: Pilot Randomized Controlled Trial” (Preprint)
Authors: Chan Windy SY , Leung Angela YM
Published: September 2020

UNSTRUCTURED

N/A
Notas sobre la noción de representación social en la sociología contemporánea. Los conceptos de simulacro y de habitus
Authors: Junqueira Lília
Published: September 2020

Este texto examina la importancia de investigar la noción de representación social en la sociología, debido al desplazamiento del interés epistemológico en diversas ciencias humanas de las dimensiones económica y cultural hacia la cultural. Al analizar su presencia desde la teoría clásica hasta los conceptos contemporáneos del simulacro de Jean Baudrillard y de habitus en Pierre Bourdieu y Norbert Elias, se concluye que ambos conceptos son indispensables dentro de sus propuestas específicas para explicar los fenómenos socioculturales contemporáneos.
Saberes, culturas y derechos sexuales en Colombia, de Mara Viveros (editora)
Authors: Urrea Giraldo Fernando
Published: September 2020

Reseña escrita por Fernando Urrea Giraldo
Prácticas productivas, lógicas culturales y transformaciones en la alta montaña. Cundinamarca, 1900-1980
Authors: Cano Castellanos Ingreet Juliet
Published: September 2020

El artículo reconstruye la transformación de los paisajes en la vereda de quebrada Honda, municipio de Cogua (departamento de Cundinamarca), a lo largo del siglo veinte. Analiza, sobre todo, las lógicas culturales que subyacen a las prácticas productivas y dan sentido a la apropiación de los recursos, el manejo de los ecosistemas y las estrategias campesinas frente a la modernización agrícola. Además, contextualiza los procesos económicos y políticos que enmarcaron las dinámicas en la vereda e imprimieron un ritmo a la transformación de los paisajes. Con base en la reconstrucción lograda, discute algunos aspectos del escenario socioambiental actual, reflexionando sobre la capacidad de adaptación de las familias campesinas, la importancia de valorar su experiencia con los ecosistemas de alta montaña y las razones de su continuidad en el campo.