bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimization of extraction of total flavonoids from Drynaria rhizome, and its effect on osteoclast differentiation
Authors: Yuan Bo , Yu Fang , Song WenJi , Zhao ZhengNan , Liang HaiDong
Published: May 2021

Purpose: To optimize the extraction parameters for total flavonoids of Drynaria rhizome, and determine their effect on osteoclast differentiation and bone resorption in vitro.

Methods: A 5-level 3-factor central composite design was applied to the optimization of extract yield of total flavonoids from Drynaria rhizome. Response Surface Methodology (RSM) design was used to optimize total flavonoids extraction from Drynaria rhizome. The independent factors included extraction temperature (A), extraction time (B) and liquid: solid ratio (C). Moreover, NFATc1, DC-STAMP, cathepsin K and MMP-9 mRNA expressions were determined.

Results: Values obtained were fitted into a second-order polynomial equation with multiple regression analysis using a statistical method. Analysis of variance results indicate that the independent variables influenced total flavonoid extraction from Drynaria rhizome. The optimal conditions for extraction yield were extraction temperature of 75 oC, extraction time of 100 min, and liquid: solid ratio of 107:1. The yield of 5.38 ± 0.62 % was consistent with these optimized conditions, which was an indication of the accuracy of the model. Experiments revealed that total flavonoids from Drynaria rhizome regulated the expression levels of NFATc1, DC-STAMP, cathepsin K and MMP-9 mRNA

Conclusion: This study has successfully optimized the extraction yield of total flavonoids from Drynaria rhizome. The total flavonoids inhibit osteoclast differentiation and bone resorption. Thus, they may be beneficial in the treatment of bone diseases.
Penetration and pharmacokinetics of ferulic acid after dermal administration
Authors: Bai Jie , Yang Chang , Du Shou-Ying , Li Peng-Yue , Dong Bo-yu , Yang Bing , Chen Xiao-nan , Cui Ya-hua
Published: May 2021

Purpose: To study the in vitro penetration and in vivo pharmacokinetics of ferulic acid (FA), and the correlation between them after dermal administration.

Methods: Franz diffusion cell was used to study in vitro penetration of FA. The concentration of FA in the Franz receiver solution was assessed by high performance liquid chromatography (HPLC). Prior to in vivo pharmacokinetics experiments, probe recovery was validated with respect to influencing factors such as flow rate, FA concentration, within-day stability and reproducibility of the probes. In in vivo pharmacokinetic experiment, six male CD-1 hairless mice were used. The micro-dialysis (MD) probe was implanted in the dermis of the rat skin, and dialysates from probe outlet were quantified directly by HPLC. In in vivo studies, deconvolution methods were used to determine the relationship between in vitro and in vivo data, and the correlation coefficient of linear equations.

Results: There was significant effect of pH (5 ~ 8) on the penetration of FA. Increase in pH caused commensurate decrease in permeability. The Cmax of FA was 300.74 ± 31.86 ng/mL while Tmax was 138.00 ± 22.80 min after dermal administration of 1 mg/mL FA dissolved in phosphate buffered saline (PBS). The correlation coefficient (r) between in vitro and in vivo data was 0.9905.

Conclusion: Both in vivo and in vitro experiments demonstrate that FA permeates the stratum corneum of skin rapidly. The unionized form of FA shows better penetration than the ionic form. In addition, results from correlation analysis indicate that the in vitro penetration characteristics of FA can be applied to predict its in vivo pharmacokinetics.
Association of CYP2C19*2 and *17 genetic variants with hypertension in Pakistani population
Authors: Riaz Sana , Mansoor Atika , Siddiqi Saima , Tareen Muhammad Usman , Rubab Sana , Batool Ayesha , Anwarullah  , Sultan Aneesa
Published: May 2021

Purpose: To investigate the association of *2 and *17 single nucleotide polymorphisms (SNPs) of CYP2C19 gene with hypertension in Pakistani population.

Methods: The study was conducted on 527 hypertensive patients and 530 unrelated healthy controls from selected regions of Pakistan. DNA was extracted from leukocytes and all patients and controls were genotyped for two SNPs (rs4244285 and rs12248560) of CYP2C19 gene by allele specific polymerase chain reaction (AS-PCR).

Results: Multi-allelic polymorphism in CYP2C19 identified four distinct phenotypes known as ultra-rapid metabolizer (UM), extensive metabolizer (EM), intermediate metabolizer (IM) and poor metabolizer (PM) in hypertensive patients and controls. For CYP2C19*2 polymorphisms, overall wild type and mutant allele frequency were 75 and 25 % in hypertensive patients, and 64.2 and 35.8 % in controls. For CYP2C19*17 polymorphisms, the overall wild type and mutant allele frequency were 66.6 and 33.4 % in hypertensive patients and 75.6 % and 24.4 % in controls. Significant difference in allele frequencies for CYP2C19*2 and *17 was demonstrated between hypertensive and non-hypertensive subjects.

Conclusion: To the best of our knowledge, this is the first report on CYP2C19 frequencies in hypertensive Pakistani patients. The finds should help clinicians to determine a suitable optimal dosage of some drugs in order to reduce side effects.
3, 4-Dihydroxyphenylethanol attenuates cadmium-induced oxidative stress, inflammation and apoptosis in rat heart
Authors: Huang Yan , Gang Hongsheng , Liang Bitao , Li Ming
Published: May 2021

Purpose: To investigate the therapeutic effect of 3, 4-dihydroxyphenylethanol (DOPET) on cadmium (Cd) induced cardiotoxicity in murine model.

Methods: Four groups of rats were used in this study (n = 6). The rats were treated with DOPET and Cd for 28 days. Biochemical parameters were determined in plasma and heart tissue homogenates.

Results: Cadmium (Cd) significantly increased lipid peroxidation and protein carbonylation. However, DOPET treatment significantly attenuated Cd-induced oxidative stress. Cd intoxication significantly increased cardiac markers {creatine kinase, lactate dehydrogenase (LDH) and cardiac troponin-I} levels in plasma, and reduced the levels of antioxidants such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase Gpx ,glutathione (GSH) and malndialdehyde (MDA) in heart tissue. These Cdinduced changes in cardiac markers and antioxidants were reversed by DOPET treatment. Cd treatment led to upregulation of protein expressions of pro-inflammatory cytokines (TNF-α and Il-6). However, DOPET supplementation brought about a decrease in the protein expressions of these cytokines. Western blot analysis revealed that Cd induced apoptosis in cardiac tissue, as was evident from alterations in protein expressions of the apoptotic inducers, Bax and cleaved caspase-3, and the anti-apoptotic factor Bcl-2. However, DOPET treatment effectively reversed Cd-induced apoptosis.

Conclusion: These results indicate that DOPET exerts cardio-protective effect against Cd-induced toxicity via antioxidant, anti-inflammatory and anti-apoptotic mechanisms.
Inhibitory effect of tetramethylpyrazine combined with propranolol on murine hemangioma endothelial cells
Authors: Jin Wan-Wan , Wu Jian-Ming , Tong Yi , Jiang Ji-Cong , Quan Hehe , Gao Yu
Published: May 2021

Purpose: To study the inhibitory effect of different doses of tetramethylpyrazine (TMP) combined with the beta-blocker, propranolol (Pro) on hemangioma endothelial (EOMA) cells.

Methods: EOMA cells were cultured in vitro with varying doses of TMP and Pro (5, 10, 20 and 40 uM). The effect of treatments on cell proliferation was assessed by MTT assay, while cell apoptosis was assayed by flow cytometry. The expressions of Bcl-2, Bax, p-mTOR), total-mammalian target of rapamycin (t-mTOR, p-p70S6) and total-p70 ribosomal protein S6 (t-p70S6) proteins were determined using Western blot.

Results: MTT data showed that when used alone, TMP had no significant inhibitory effect on EOMA cells (p > 0.05). However, when TMP was combined with propranolol, there was significant inhibition of EOMA cells, and that the inhibition is dependent on TMP dose. Flow cytometry results showed that the combination of TMP and Pro induced EOMA cell apoptosis dose-dependently (p < 0.05). Moreover, TMP dose-dependently inhibited the phosphorylation of mTOR and p70S6 in EOMA cells, and enhanced Bax expression, but downregulated Bcl-2 (p < 0.05).

Conclusion: These results suggest that TMP enhances the inhibitory influence of Pro p-mTOR and pp-70S6 in EOMA cells in a dose-dependent manner. Thus, TMP may enhance Pro-induced inhibition of the growth of endothelial cells, and promote apoptosis through suppression of activation of PI3K/AKT signal route. These findings provide a theoretical basis for the clinical application of TMP/Pro combination for the treatment of hemangioma.
Investing in Human Resources as a Platform for National Security in Nigeria: The Role of Social Studies Education
Authors: Onyeatoelu Okobia Ayodele
Published: May 2021

Nigeria’s political elites have toyed with the pathway to Nigeria’s national security, and therefore, placed Nigeria and her people on a perpetual developmental backwardness. Sadly, Nigeria, the supposed giant of Africa has been weighed down by the challenge of corruption, as well as insecurity. The deficiency in human capital development in Nigeria today is exerting untold pressure on her national development plans, policies and programmes. The development of human resource s isindispensable for the developmental strive of any continent or nation. Hence, the inability of the Nigerian state to fully actualize her human capital development drive calls for concern. The aim of this article, therefore, is to investigate into the indispensability of investing human capital development in fostering national security in Nigeria. Social studies education is an instrument for renewal of some societal practices that constitute obstacles to national security and development. Consequently, this paper will examine the place of social studies education in the context of Nigeria for national security. The roles social studies education could play in producing good citizens, who could assist in no small measure in tackling this complex problem of national insecurity in Nigeria were discussed. In conclusion, the paper has logically established the fact that, there is significant correlation between social studies education and human capital development. Finally, workable recommendations are given, among them is that government should lay more emphasis on the teaching of social studies at all levels of its educational system - to foster moral development in youths

Keywords: National Security, Human Resources, Social Studies Education, Investment.
Restructuring, National Security and Nigeria’s Relationship with the External World
Authors: Pally Agidi Ejime
Published: May 2021

Nigeria as a nation has been experiencing security challenges at alarming level in the last few years. This has taken various forms such as kidnapping from ransom, herders and farmers clashes, organized crimes, and cybercrimes, implosive movement of small and light arms. Trans border crimes, human trafficking, and slavery among others. This has affected Nigeria’s external relations with the outside world negatively in various ways, such as constriction of bilateral trade volume, cold diplomatic relations, low tourism attraction, low educational exchang e, reduction of military trainings abroad, refusal of arms purchase, low foreign investments among others. The diversity nature of the Nigerian state stands a gap in finding solutions to the myriads of problems as Nigeria’s image abroad has been dented badly. Restructuring the Nigerian state in various spheres has been the agitation of many Nigerians in the recent time. This paper therefore examines restructuring the Nigerian state, National security and its implications on her relationship with the external world. It is a qualitative paper that focused on secondary sources of information, and adopted structural functional theory as its framework of analysis. The paper argued that restructuring the political structures in Nigeria will advance quality security in Nigeria. It is the opinion of the paper that improves security in the country will enhance robust Nigerian’s relationship with the external world. The paper recommended among others, the restructuring of political economic and social structures through the instrument and legitimacy of national conference. This has to be backed by legislations from the national and state assembly.

Keywords: Restructuring, External Relationships, National Security, Political Structure, National Conference
Spotlight on Challenges and Prospect of Directing in Nollywood: A Decade’s Study (2006-2016)
Authors: Anyira Kingsley Chukwuemeka , Joe Divine Sheriff Uchenna
Published: May 2021

The art of video film directing is all encompassing as the director deals with virtually all aspects of film production. This comes with herculean challenges that tend to mar the efforts of directors if not properly addressed. Film scholars cum critics have done a lot of work investing the challenges of the Nigerian Video Film industry with little or no effort to directly ascertain the peculiar challenges of each sector of the industry. To this effect, the paper seeks to source from the directors what these challenges have been over the decade in view and as well through the affected, proffer plausible suppositions asmeasure to ameliorate the identified challenges. In doing so, this paper adopts the view point that the director is the author of the film and thus engages the Survey research method wherein Personal interviews are employed as data collation tool and later analyzed with inferences made from the responses. Conclusively, it anchors on the directors’ views of possible ways to improve/enhance the director’s art in future productions.
Achieving National Security in Nigeria through Education
Authors: Omoroje Seji D.O. , Egbule Philip Onyekachukwu , Emuebie John Ejime
Published: May 2021

This paper discusses how Nigeria as a nation can achieve national security through, not just education, but qualitative education. National security has been described in this paper, as freedom from or resilience against potential harm caused by others. For easy comprehension and assimilation, the paper was strategically broken down into six, (6) distinct sections, to wit; conceptualization of key words, causes of insecurity in Nigeria, effects of insecurity in Nigeria, role of education in checkmating insecurity, previous efforts by governments to address insecurity issues and; conclusion and recommendations. The paper was able to establish the fact that quality education can reduce incidences of insecurity, even if not totally eradicated. Education, this paper revealed is a major weapon of progressive social change. The paper concludes that sound education anchored on good educational policies and implementation can reduce, to a manageable extent, insecurity in Nigeria. Therefore some recommendations, such as declaring a state of emergency in the educational sector to reduce illiteracy, were proffered. This, the paper suggested, among others will provide a panacea for the problem of insecurity in Nigeria.
Uncovering absences and gaps: using Ketso in qualitative research for accessible tourism
Authors: McIntosh Alison , Cockburn-Wootten Cheryl
Published: May 2021

Engagement of stakeholders in the research process provides valuable insights around tourism issues yet can be fraught with challenges. Ketso is a toolkit that can help overcome these barriers to facilitate stakeholder inclusion and collaboration. Drawing on a study into accessibility and tourism, this paper provides critical reflections on the potential of Ketso as a qualitative method in bringing together diverse stakeholders for inclusive dialogue around social change. Ketso can develop opportunities for change in the tourism system by making the absences of knowledge and assumptions in the worldviews of powerful tourism stakeholders apparent. Our analysis revealed how Ketso enabled inclusive collaboration to engender both tacit and wider community stakeholder knowledge, building capacity for co-created solutions to make tourism more accessible (barrier-free) for travellers with disabilities.
L’Âme en folie de François de Curel : à la recherche d’un nouveau paradigme dramatique
Authors: Kaczmarek Tomasz
Published: May 2021

L’Âme en folie by François de Curel: In search of a new dramatic paradigm

The author of the article studies Curel’s play, which testifies to the crisis of traditional drama, announced at the turn of the 20th century. Curel seems to destroy the canonical form of “drama-in-life”, based on a dramatic progression of the action and on the character as an active agent ensuring this same progression, by proposing a new paradigm of “drama-of-life”. The latter moves away from classic prerogatives to focus on the inner life of the protagonist. Instead of focusing on episodes that inevitably lead to disaster, the French writer attempts to embrace the evolution of the characters’ souls. This is how he passes from “agonistic drama” to an “ontological” one.
Il tema della desolazione in L’altra verità. Diario di una diversa, di Alda Merini
Authors: Cavallo Stefano
Published: May 2021

The theme of desolation in L’altra verità. Diario di una diversa, by Alda Merini

The life of Alda Merini has always been connected with abandonment, reclusion, abuse, failure of motherhood: in one word, of that kind of loneliness, suffering and inexpressibility that could be called ‘desolation’. The author analyses the construction of the subject in Merini’s L’altra verità. Diario di una diversa: a diary, a reportage, but even a metaphor of the condition of the artist. The paper aims to show that desolation (as product of suffering, loneliness and inexpressibility), is a key element for the condition of the artist (and the subject itself) in 20th century. But it might be particularly a keyword for Alda Merini, marking her way to achieve a state of grace as a writer, and as a woman.
Su alcuni metodi applicati a grammatiche di italiano per polacchi tra il XIX e il XX secolo
Authors: Palmarini Luca
Published: May 2021

On some methods applied to Italian grammars for Poles between the 19th and 20th centuries

The article aims to compare and analyse Italian grammars and manuals for Polish users published between the second half of the 19th century and the beginning of the 20th century. The purpose is to observe the general trends on the methods proposed, the changes taking place and the possible influences on teaching of Western languages as foreign languages in a historical moment when after the Third Partition Poland had ceased to exist as a sovereign state.
World Orders and the Politics of Exclusion: from Westphalia to Today
Authors: Tsygankov A. P.
Published: May 2021

Lascurettes, Kyle M. Orders of Exclusion: Th e Strategic Sources of Order in International Relations. New York: Oxford University Press, 2020.
Serbia’s Foreign Policy in the South-West Direction
Authors: Pivovarenko A. А.
Published: May 2021

This article suggests a rethinking of Serbian-Albanian relations. Contemporary research tends to reduce this problem exclusively to the Serbia-Kosovo issue, which is usually regarded with a value-based approach. As a result, the issue of Serbia’s foreign policy strategy in the south-west and south direction, which also includes the Republic of Albania and other states (Montenegro, North Macedonia), where the role of the Albanian factor is signiﬁ cant, remains outside the scope of the analysis. The purpose of this article is to examine more closely the logic of Serbia’s foreign policy activities in the south-western (Albanian) direction, taking into account the historical context and current trends associated with the active implementation of infrastructure projects in the entire Balkan region. Given that these projects cover both Serbia and Albania, it is appropriate to assume that Belgrade and Pristina have a mutual interest in forming a predictable non-conﬂ ict space and in certain coordination of their approaches to conducting politics in their border area. This, in turn, requires a rethinking of Serbia’s foreign policy strategy in the southwestern (Albanian) direction. To this end, the author analyzes both the historical evolution of Belgrade’s position on the Albanian-Kosovo issue and considers it in the context of modern regional infrastructure projects. Considering the structural regional changes, taking place since the second half of the 2010s, the author comes to the conclusion that Belgrade is facing a dilemma between the self-signiﬁ cant signiﬁ cance of the Kosovo issue and the interest in forming a predictable and stable space to the southwest of its own borders. This dilemma determines the logic of modern Serbia’s foreign policy actions.
The Cohen-Macaulay representation type of arithmetically Cohen-Macaulay varieties
Authors: Faenzi Daniele , Pons-Llopis Joan
Published: May 2021

We show that all reduced closed subschemes of projective space that have a Cohen-Macaulay graded coordinate ring are of wild Cohen-Macaulay type, except for a few cases which we completely classify.
Le moi et le pouvoir dans la littérature russe de l’époque médiévale
Authors: Subbotina Galina
Published: May 2021

Поскольку интерес личности к самой себе является феноменом относительно новым в истории культуры, кажется почти немыслимымнайти элементы рефлексивности в русской средневековой литературе. Тем не менее нам представляется возможным найти признаки осознанного усилия по самоанализу в целом ряде произведений: «Поучении Владимира Мономаха», «Молении Даниила Заточника», переписке Ивана Грозного с Андреем Курбским, «Житии протопопа Аввакума, им самим написанном». Мы постараемся показать, что именно в рамках взаимоотношений с властью (государственной или церковной) проблемы самоописания и самоанализа начинают вырисовываться на этом самом раннем этапе развития русской литературы.

As interest of an individual to self-examination is a relatively recent phenomenon, it seems almost unthinkable to find elements of reflexive analysis of the mind in medieval Russian literature. Nevertheless we think that it is possible to bring to light some indicators - very weakly expressed but distinct - of a deliberate effort of introspection in several texts of this period. To demonstrate this we shall analyze the following works: The Instruction of Vladimir Monpmakh, Praying of Daniel the Immured, the correspondence between Ivan the Terrible and Andrej Jurbskij and The hagiography of Archpriest Avvakum written by himself. We shall try to show that self-presentation and self-analysis appear at this initial period of development of Russian literature thanks to the relations with the State and religious power.

La notion de « culte du moi » étant moderne, il semble quasi impensable de relever des indices de réflexivité dans la littérature russe médiévale. Pourtant, nous y percevons un effort d’introspection dans de nombreux textes, tels L’Instruction de Vladimir Monomaque (Poučenie Vladimira Monomaxa), la Supplique de Daniil le Reclus (Molenie Daniila Zatočnika), la correspondance entre Ivan le Terrible et Andrej Kurbskij, l’Hagiographie de l’archiprêtre Avvakum écrite par lui‑même (Žitie protopopa Avvakuma, im samim napisannoe). Ainsi, nous nous attacherons à montrer comment, dans le cadre des relations avec le pouvoir – étatique ou religieux –, les formes et les enjeux de l’auto-présentation et de l’auto-analyse se profilent à cette époque initiale du développement de la littérature russe.
Introduction
Authors: Poujol Catherine
Published: May 2021

Pour qui, pourquoi, comment parler de soi ? De quelle manière s’articule le discours autobiographique, les discours autobiographiques ? Le sujet est largement rebattu et la littérature foisonne d’exemples aussi célèbres que convaincants.Comment ces discours autobiographiques peuvent-ils s’inscrire dans les interstices souvent réduits que concède le pouvoir politique, mais aussi, celui de la société englobant les individus auquel nul n’échappe, fût-il lui-même l’incarnation du pouvoir ? Comment parviennent-ils à « prendre le pouvoir » le temps de leur énonciation, par surprise, par stratégie, par inertie ? À le distordre, le minoriser, le transcender. La question mérite d’être posée.Ce numéro spécial de Slovo consacré au « discours autobiographique à l’épreuve des pouvoirs en Europe – Russie – Eurasie » se veut une polyphonie de voix diverses connues ou ignorées, où résonneront celles des souverains eux-mêmes, comme celles des simples individus prenant la parole et accédant ainsi à une notoriété fugace, à côté de celles plus attendues des écrivains et autres personnalités reconnues par l’histoire.
Le Rêve d'un homme ridicule (Fedor Dostoïevski, 1877) adapté par Aleksandr Petrov (1992) : quand l'adaptation devient extrapolation poétique
Authors: Jacq Jasmine
Published: May 2021

it was in 1992 that Aleksandr Petrov, a budding star in Russian animated film, directed The Dream of a Ridiculous Man, based on Dostoevsky’s short story of the same name, first published in 1877. Choosing this extremely complex work, which engages with all Dostoevsky’s views on religion, seemed to correspond to some deep inner need on the part of the filmmaker. The resulting work, a 20-minute short, is an extremely powerful narrative that testifies to the striking and almost uncanny affinity that exists between Dostoevsky & Petrov – a true meeting of minds. On the one hand Petrov throws himself into condensing and redeploying the original text, using various evocative means (such as noise, music, rhythm & colour) imbued with Dostoevsky’s narrative world. But above all it’s the element of fantasy and the central presence of the dream in the text that stands out, providing an ideal subject matter for a filmaker deeply inspired by the notions of slipping (from one reality to another), passages and metamorphoses.

en 1992, Aleksandr Petrov, étoile montante de l’animation russe, réalisait Le Rêve d’un homme ridicule, d’après la nouvelle de Dostoïevski (1877).Le choix de cette oeuvre extrêmement complexe, sorte de synthèse de la pensée religieuse de Dostoïevski, paraît répondre à une nécessité intérieure pour le cinéaste. L’oeuvre qui en ressort, court-métrage de vingt minutes, est un film d’une puissance narrative exceptionnelle, frappant par une communauté d’esprit et un niveau d’intimité troublants avec l’auteur. D’une part, Petrov s’adonne au nécessaire travail de condensation du texte, redéployé narrativement à travers différents procédés suggestifs profondément imprégnés de l’univers diégétique de Dostoïevski (bruitages, musique, rythme, couleurs...). Surtout, la dimension fantastique et la présence centrale du rêve dans le texte en font un matériau idéal pour un cinéastetrès inspiré par les notions de glissement (d’une réalité à une autre), de passages et de métamorphoses.

В 1992 году Александр Петров, восходящая звезда российского анимационного кинематографа, создаёт Сон смешного человека поодноимённому рассказу Ф.М. Достоевского (1877). Выбор этого крайне cложного произведения, некого синтеза религиозной мысли Достоевского, словно основан на внутренней потребности режиссёра. Получившаяся работа, двадцатиминутный короткометражный фильм, обладает невероятной повествовательной силой и поражает единением мысли и степенью близости с автором. С одной стороны, Петров выполняет необходимую работу по сжатию текста, который он изобразительно перестраивает через различные суггестивные приёмы (шумовое оформление, музыка, ритм, цвета...), глубоко пропитанные диегетическим миром Достоевского. С другой стороны, фантастический аспект и центральное место сна в тексте представляют идеальный материал для режиссёра, которого особо вдохновляют понятия перемещения (из одной реальности в другую), переходa и метаморфозы.
Bilingualism and Diglossia in Bulgaria-a New Perspective upon Their Contemporary State
Authors: Armianov Gueorgui
Published: May 2021

The article examines some particular forms of diglossia and bilinguism in Bulgaria. It takes into account the evolution of Bulgarian society over the last thirty years and the processes of language interference associated with the political changes, or influenced by them. The analysis is directed mainly at the slow disappearance of the regional dialects and their gradual and systematic replacement by other substandard forms such as colloquial speech, urbanolects or to some extent social dialects. Special attention is paid to the Turkish language in Bulgaria which enters into more complex relationships with the standard language and represents a specific and very interesting case of bilingualism, combined with diglossia.

Cet article examine certaines formes particulières de diglossie et de bilinguisme en Bulgarie. Il prend en compte l’évolution de la société bulgare au cours des trente dernières années et les processus d’interférence linguistique associés aux changements politiques ou influencés par ceux ci. L’analyse porte principalement sur la disparition progressive des dialectes régionaux et sur leur remplacement progressif et systématique par d’autres formes substandards, telles que le langage familier, le langage populaire, les urbanolectes ou les dialectes sociaux. Une attention particulière est accordée à la langue turque en Bulgarie, qui entretient des relations plus complexes avec la langue standard et représente un cas spécifique et très intéressant de bilinguisme, associé à la diglossie.
Predictive Analytics on Academic Performance in Higher Education Institution during COVID-19 using Regression Model
Authors: Zulkri Muhammad Farezuan , Shaharudin Shazlyn Milleana , Rajak Noor Azrin Abdul , Ibrahim Muhammad Safwan
Published: May 2021

The coronavirus disease 2019 (COVID-19) outbreak in December 2019 had affected the way of living for people around the world including students in educational institutions. These students had to prepare for the continuity of their study mentally and physically by adapting to the online teaching and learning approach, which can significantly impact their academic performance. Hence, this study examines the students' academic performance on the online teaching and learning approach, thus predicting their academic performance for the upcoming semester. This study enables various actions to be taken in improving and maintaining the student's performance in their study activities. The study was conducted on undergraduate students from the Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris. This paper presents the prediction of the student's academic performance with a linear regression model. Evidently, the result shows that the student's academic performance continually improves while adapting to the online teaching and learning approach. It also shows that there were few respondents affected while adapting to this new norm approach. Hence, the future development of the regression model can be improved by having a more comprehensive range of Malaysian universities' data.
Gestión Administrativa como herramienta para una Excelencia Empresarial
Authors:   Consultora Independiente, Vera Solórzano Lady Diana , Baque Sánchez Erick Raúl ,   Universidad Estatal del sur de Manabí, Vidal Astudillo Boris Esteban ,   Consultor Independiente, Morocho Yuquilema Carlos Julio ,   Tecnológico Liceo Cristiano de Guayaquil
Published: May 2021

Este libro presenta aspectos de la gestión administrativa como herramienta para una excelencia empresarial relacionados con la cultura organizacional, donde se destacan los aspectos de las organizaciones y su cultura organizacional enfocadas estas hacia una cultura global. Se hace en énfasis en el efecto Pigmalión en el ámbito empresarial, como elemento transformador por su efecto a través de las expectativas. Se aborda la gestión administrativa como herramienta para la actividad emprendedora de los comerciantes informales en la generación de capacidades individuales y colectivas, donde se enfatiza en la actividad emprendedora de los comerciantes informal en la generación de capacidades individuales y colectivas. De acuerdo con lo planteado se realiza un análisis de la gestión del conocimiento organizativo para una excelencia empresarial, donde se exponen los aspectos fundamentales de la gestión del conocimiento para una excelencia empresarial, analizándose los líderes en las organizaciones y la gestión del conocimiento para poder crear las organizaciones inteligentes y se fundamenta el rol del gerente-líder en las organizaciones inteligente, como base de una estrategia de desarrollo organizacional.
Construcción de un diplomado en estadística aplicada a la investigación: una experiencia en Google Classroom
Authors: Chipia Joan , Paredes Yorman
Published: May 2021

El objetivo fue describir una experiencia educativa sobre la construcción de un Diplomado en Estadística Aplicada a la Investigación con Google Classroom, Facultad de Medicina, Universidad de Los Andes, Mérida, Venezuela, 2018-2020. Método: enfoque cuantitativo, tipo de investigación descriptiva, diseño no experimental, de campo, prospectivo. La muestra fue de 168 participantes en siete cohortes del diplomado. Resultados: 83,3% (n=140) culminaron el diplomado, el promedio y desviación estándar de calificaciones fue de 16,98 ± 1,473 puntos. Conclusiones: la construcción del diplomado con la utilización de Google Classroom fue efectiva. El proceso educativo bajo la modalidad b-learning mostró fluidez y permitió sortear dificultades logísticas.
Internet projects in the formation of professional competences in students
Authors: Arifullin Marat V. , Borisov Andrei V. , Popkova Alena A. , Melnikov Daniil D. , Zubkova Yana V.
Published: May 2021

The purpose of the article was to carry out an analysis of the experience of implementing Internet projects in the formation of the professional competence of students. The study involved 154 students aged 20 to 23 years. The article reveals the scale of general self-efficacy of R. Schwarzer and M. Erusalem and the Karpov reflexivity questionnaire as methods that allow determining the student's ability to independently navigate in conditions of uncertainty and solve professional problems, correct their actions to achieve the best result. The effectiveness of the Internet design of students of higher educational institutions was calculated as a percentage of the maximum possible result.
Influence of the technical equipment on the educational process
Authors: Ostanina Elena A.
Published: May 2021

Currently, the relevance of the study is due to external global challenges, which include COVID-19 pandemic, which provoked an emergency in a number of countries. Assessment of the psychological state of participants in the educational process and its normalization can help to minimize the decline in the quality of education. The purpose of this study is to identify the possibility of organizing a high-quality distance learning process by identifying negative factors and leveling their impact during emergency situations and situations close to them. The study identifiedinternal and external factors affecting the psychological state of teachers. The correlation between the harmony of the teacher's personality and successful labor activity has been substantiated. In the course of the work, the problem of changing the technical equipment of participants in the educational process during an emergency and close to it was revealed. As a result of the research, the author came to a well-grounded conclusion that the psychological state of the participants in the learning processhas a significant impact on the educational process when organizing distance learning. The most significant in this regard is the psychoemotional state of the teacher as the organizer of the process and mentor. The article provides a number of recommendations for leveling the destabilizing factors that have a negative impact on the psychological state of the participants in the learning process and affect its quality.
La importancia de los pisos de protección social para los adultos mayores en México
Authors: Mendizábal Bermúdez Gabriela
Published: May 2021

El complejo mundo laboral, cada vez más, excluye a los adultos mayores. En América Latina la oferta laboral para este grupo etario tiende a ser menor, ya que los perciben como incapacitados para desempeñar algunas actividades, motivo por el cual les cierran las puertas limitando entre otros su derecho a la seguridad social. Por tales consideraciones resulta importante que se tomen medidas direccionadas a la solución de dichos problemas.

El presente artículo muestra un análisis del impacto de la iniciativa internacional del piso de protección social en beneficio de las personas adultas mayores, analizando aspectos referentes al aseguramiento social y la situación pensionaria a la que se enfrentan los adultos mayores. Por otro lado, se analiza la importancia y el papel que toman los pisos de protección social con referencia a los adultos mayores en México y los principales programas asistenciales que les otorgan protección social.
Faktor Risiko Terjadinya Penyakit Jantung Koroner pada Pasien di Unit Rawat Jalan Rumah Sakit Panti Rapih Yogyakarta
Authors: Deviana Widayanti  , Chatarina Setya Widyastuti
Published: May 2021

Background: Coronary Heart Disease (CHD) Is a condition when the arteries that supply blood to the heart wall experience hardening and narrowing. It is estimated that 30% of coronary heart disease causes death worldwide.

Objective: This study aims to determine the risk factors for CHD in Panti Rapih

Hospital.

Methods: This descriptive study aims to determine the risk factors for CHD in outpatients at Panti Rapih Hospital. The population is patients who have been diagnosed with coronary heart disease and the sample was taken by 50 respondents with non-random accidental sampling technique. This research take the data use questionnaire and make univariat analysis.

Results: Risk factors for CHD are a number of factors that cannot be changed: family history of 42%, age = 40 years 95% in men and 95% age = 65 years in women. Factors that can be changed are: Smoking 78%, history of hypertension 68%, history of diabetes mellitus 28%, dyslipidemic 90%, excess body weight42% and lack of exercise 38%.

Conclusion: Risk factors for CHD that cannot be changed: family history of 42%, age = 40 years 95% in men and 95% age = 65 years in women. Factors that can be changed are: Smoking 78%, history of hypertension 68%, history of diabetes mellitus 28%, dyslipidemic 90%, excess body weight 42% and lack of exercise 38%.

 

 

Keywords: coronary heart disease, risk factors
TINGKAT KECEMASAN PASIEN YANG MENJALANI OPERASI DI RUMAH SAKIT PANTI RAPIH YOGYAKARTA
Authors: Anggit Septy Nugraheni  , Siwi Ikaristi Maria Theresia
Published: May 2021

Background: Anxiety is often associated with a life-threatening event such as during surgery. The emergence of anxiety begins in the preoperative phase as the initial phase in the surgical process. For someone who is undergoing surgery for the first time, an anxious response will emerge so that it can affect the success of the operation.

 

Objective: The purpose of this study was to determine the level of anxiety of patients who underwent the first operation at RapihPanti Hospital Yogyakarta.

 

Methods: This research uses descriptive quantitative survey method, with a total sample of 30 respondents using purposive sampling technique. The instrument to assess used was the Hamilton Rating Scale for Anxiety (HRS-A) which was translated into Indonesian.

 

Results: The results showed that the mild anxiety level was in the early elderly 16.7%. The most moderate level of anxiety in the elderly was 13.3% and severe anxiety in late adolescence was 3.3%. Based on gender, the level of mild anxiety was mostly experienced by men 33.3% and moderate anxiety was mostly experienced by women 30%. As many as 60% of patients get information sources on surgery from health workers and seek information on social media independently.

 

Conclusion: The level of anxiety is mild, moderate and severe experienced by all age groups. Types of gender men experience the mild anxiety level and women experience the most moderate level of anxiety. Recommendation for nurses is to provide assistance in knowledge, understanding, and spiritual support, besides the nurses assess the level of anxiety in all patients undergoing surgery. For hospitals develop social media communication as a source of information on surgery.
Hubungan Paritas, Umur Ibu Dengan Perdarahan Post- Partum Primer di Rumah Sakit Panti Rapih Yogyakarta Tahun 2017- 2018
Authors: Theresia Heni Lestari  , Theresia Endah Marianingsih  , Yuliasti Eka Purnamaningrum
Published: May 2021

Background: The cause of AKI in DIY 2018, 11% of post-partum hemorrhage, with a gap in MMR target and achievement <102 / 100,000 live births, MMR in 2018: 111.5 / 100,000 live births, indicating an increase in MMR. In the same year at Panti Rapih Hospital, there was an increase in the incidence of post-partum hemorrhage by 6%, with 62.8% of parity at risk, 53.5% of age at risk.

Objective: of the study was to determine the relationship between parity and maternal age with the incidence of primary post-partum hemorrhage at Panti Rapih Hospital in 2017-2018.

Methods: observational, cross sectional design, sample 43 people. Chi Square Test data analysis.

Results: There was a significant relationship between parity and the incidence of primary post partum hemorrhage (p-value = 0.011). There was a significant relationship between age and the incidence of primary post-partum hemorrhage at Panti Rapih Hospital (p-value = 0.014).

Conclusion: There is a significant relationship between parity, maternal age <20 years or> 35 years with the incidence of primary post partum hemorrhage at Panti Rapih Hospital in 2017-2018.
Gambaran Self-Management Pada Penderita DM Tipe 2 di Salah Satu Rumah Swasta di Klaten
Authors: Hanna Febriani Dita , Sendy Ayuningtyas Grayssa , Yuliyati Maria
Published: May 2021

Latar belakang: Diabetes melitus tipe 2 merupakan suatu penyakit metabolik dengan karakteristik atau ciri khusus hiperglikemia. Diabetes Melitus dapat mempengaruhi kualitas hidup pasien hingga membutuhkan perawatan medis berkelanjutan. Oleh karena itu, penderita harus mampu menjalankan self-management atau manajemen diri yang baik.

Tujuan: Penelitian ini bertujuan untuk mengetahui gambaran self-management pasien dengan diabetes melitus tipe 2 di salah satu rumah sakit swasta di Klaten.

Metode: Penelitian ini menggunakan desain penelitiaan deskriptif kuantitatif, dengan menggunakan instrumen The Diabetes Self-management Questionnaire (DSMQ) untuk mengukur self-management diabetes. Jumlah sampel dalam penelitian ini adalah 40 pasien DM yang datang di poliklinik Rumah Sakit.

Hasil: Hasil penelitian didapatkan bahwa sebagian besar responden memiliki self-management baik (85%) dengan skor rata – rata masing – masing domain diet (7,12), management glukosa (7,93), aktivitas fisik (8,13), penggunaan layanan kesehatan (7,25). Dari keempat domain self-management, domain aktivitas fisik paling baik diantara keempat domain yang ada, sedangkan untuk domain diet paling buruk diantara keempat domain yang ada.

Simpulan: Berdasarkan hasil penelitian ini dapat disimpulkan bahwa sebagian besar pasien dengan diabetes mellitus tipe 2 memiliki self-management yang baik.
Faktor yang Mempengaruhi Kepatuhan Ibu Hamil dalam Melakukan Kunjungan Antenatal Care (ANC) di Layanan Kesehatan.pdf
Authors: Setiyorini Ana , Yuliana Sijabat Friska , Anita Sari Maudy
Published: May 2021

Background: Antenatal care (ANC) is a health service from professionals for pregnant women in accordance with service standards that implemented to improve the physical and mental health of pregnant women optimally, so that they able to face childbirth, postpartum periode, exclusive breastfeeding preparation, and periode of reproductive system return to its normal pre-pregnant stage. Mother’s adherence in ANC attendance can detect and treat pregnancy problems which could impact on maternal mortality. Inadequate utilization of health services can be caused by many factors, including knowledge of pregnant women, distance of residence, family income, information from media, family support, and health workers’ factor.

Objective: Determined the factors that influence the adherence of pregnant women to ANC attendance at Panti Rini Hospital Yogyakarta 

Method: This research is a descriptive analytic study with a cross sectional design at Panti Rini Hospital Yogyakarta. The sample in this study were thirty-two of third trimester pregnant women who visited antenatal care during 15 December 2020-6 January 2021 which recruited with an accidental sampling. Univariate, bivariate analysis with the Spearman correlation statistical test used to determine the relationship of each variables (p-value) at the level of significance p <0.05. 

Results: Factors that influence maternal adherence to ANC attendance were family support (p-value: 0,000). The factors that did not affect were maternal age (p-value: 0.868), maternal education (p-value: 0.644), employment status (p-value: 0.224), maternal knowledge (p-value: 0.175), distance of residence (p-value: 0.613), family income (p-value: 0.921), media information (p-value: 0.233), support from officers (p-value: 0.141).

Conclusions: Factors that influence maternal adherence to ANC attendance were family support. The factors that did not affect were maternal age, maternal education, employment status, maternal knowledge, distance of residence, family income, media information, support from officers. It is hoped that the family will always offer support the mother in checking her pregnancy.
Book Review: Moser, K., & Zelaya, K. (Eds.). (2020). The Metaphor of the Monster: Interdisciplinary Approaches to Understanding the Monstrous Other in Literature. Bloomsbury Publishing USA
Authors: Alberro Heather
Published: May 2021

This engrossing interdisciplinary collection, edited by French studies Professor Keith Moser and Central American literary scholar Karina Zelaya of Mississippi State University, explores numerous iterations- historical, literary, ecological, sexual- of the monstrous ‘other’. As such, the collection would be of interest and relevance to scholars from a host of disciplines: from international relations and security studies to environmental ethics and postcolonial studies. The work is divided into four parts, each featuring essays that correspond to a particular sub-discipline within monster studies: Part I (Ecological perspectives), Part II (Transgressive, Monstrous gender and Corporality), Part III (Teaching monstrosity in the (Post-)Modern World), and Part IV (Monstrosity in World Literature). This structure is particularly useful in helping the reader discern the unique contributions offered by each field to the analysis of monster metaphors.