bluuebunny/crossref_metadata_2025 huggingface dataset:
“Smart” Educational Technology: A Conversation between sava saheli singh, Jade E. Davis, and Chris Gilliard
Authors: Singh Sava saheli , Davis Jade E. , Gilliard Chris
Published: June 2021

A conversation about smart technology use in educational settings.
Pediatric hospital healthcare workers and pertussis; a seroprevalence study
Authors: Özer Selcen , Oğuz Vildan Avkan
Published: June 2021

Background. This study aimed to assess pertussis seroprevalence among healthcare workers (HCWs) of a university children`s hospital and to determine their opinions on whether to get the pertussis vaccine booster dose in adulthood.
Methods. This cross-sectional study was carried out between January 2018 and March 2019. Data recording forms were filled by the face to face interview method. Anti-pertussis toxin IgG (Anti-PT IgG) antibody levels were determined quantitatively from the serum samples using a commercial enzyme-linked immunosorbent assay (ELISA) kit. Anti-PT IgG results were interpreted according to World Health Organization (WHO) recommendations.
Results. Of the 169 HCWs included in the study, 67 (39.6%) were seronegative and susceptible to pertussis. Seropositivity was significantly higher among HCWs who worked 40-80 hours per week. Thirty-six (21.3%) HCWs had high anti-PT IgG levels, indicating recent infection in the past few years. High-level positivity was significantly more common among HCWs using macrolide antibiotics due to prolonged cough. Anti-PT IgG levels of three (1.8%) were compatible with acute infection and they were not followed up with suspicion of whooping cough and were not isolated. While 125 (74.0%) of the participants said they could get the pertussis vaccine booster dose, only three (1.8%) had done so.
Conclusions. The fact that 39.6% of HCWs were seronegative, emphasized the need for the pertussis booster dose. More than 20% of HCWs have had the acute infection without pertussis diagnosis in the past few years. Adult vaccination awareness in HCWs has not yet created a change in behavior. The high rate of seropositivity in macrolide users also shows that we cannot prevent its spread despite treatment. These findings highlight the fact that pertussis can occur in adult age groups and that eradication cannot be achieved without effective adult immunization and surveillance.
Seroprevalence of Anti- N-methyl-D-aspartate receptor antibodies in children with seizures of unknown cause
Authors: Abdulamer Mohammed Abdulrasol , Saadi Nebal Waill , Ghalib-Yassin Batool Ali , Al-Jumaili Imad
Published: June 2021

Background. Anti- N-methyl-D-aspartate receptor (NMDAR) antibodies were found most probably to be accompanied by seizures, particularly in children and sometimes it may be the sole presenting feature. Therefore, testing these antibodies in children with seizure of unexplained cause might be helpful to identify the spectrum of these antibody-mediated disorders. The objective of this study was to determine the frequency of anti-NMDAR antibodies in patients who presented with seizures of unknown cause.
Methods. A case-control study was conducted in two hospitals in Medical City Complex-Baghdad in 2019. Children aged 2-18 years who manifested seizures solely without identified causes were recruited over a period of ten months, with an additional sex- and age-matched control group (forty children in each group). Serum was tested in both groups for anti-NMDAR antibodies.
Results. In the study group, males predominated in ages younger than 5 years. The mean age was 6.6 years and the mean duration since their seizures` onset was 2 months. In contrast to male patients, female patients manifested more focal seizures. Only 5 patients (12.5%) were positive for Anti- NMDAR antibodies, in contrast to no one in the control group. Significantly, most of the seropositive patients were females (4, 80%) and showed focal types of seizures (4, 80%).
Conclusions. This is a preliminary epidemiological study about the prevalence of anti-NMDAR antibodies in a sample of pediatric patients with isolated seizures of unknown cause. Anti-NMDAR antibodies were found to be prevalent in a relatively small proportion of children who presented with seizures of unknown causes. Demographic characteristics of the patients with variable testing status were found to be nearly comparable to the results from other related studies.
Clinical and demographic characteristics of childhood neuro-ophthalmology diseases at a tertiary eye care center
Authors: Kavuncu Sevim Kuyumcu , Nalçacıoğlu Pınar , Acaroğlu Gölge
Published: June 2021

Background. To evaluate the demographic, etiological, and clinical properties, as well as the treatment modalities of neuro-ophthalmological diseases in childhood.
Methods. We retrospectively analyzed the clinical data of patients younger than 18 years old who were referred to the Neuro-Ophthalmology Department of Ulucanlar Eye Hospital from 2004 to 2019.
Results. Of 1,910 patients who presented to the Neuro-Ophthalmology Department, 128 (6.7%) were younger than 18 years old at diagnosis, and their data were analyzed. The three most common diagnoses were congenital optic disc (OD) abnormalities in 43 (33.5%), optic neuropathies in 42 (32.8%), and idiopathic intracranial hypertension in 11 (8.5%) patients. The most frequent symptoms were as follows: decreased visual acuity in 36 (28.1%), headache in 32 (25%), and no symptoms in 19 (14.8%) patients. The best visual prognosis was associated with inflammatory optic neuritis, while hereditary and compressive optic neuropathy resulted in poor visual acuity outcomes.
Conclusions. Congenital OD abnormalities and optic neuropathies are the most frequently seen disorders among children with neuro-ophthalmological diseases. Clinicians should also be aware that children without any symptoms may also have neuro-ophthalmological disorders.
Two-Component Generalization of a Generalized the Short Pulse Equation
Authors: Allami Mohammed
Published: June 2021

In this article, we introduce a two-component generalization for a new generalization type of the short pulse equation was recently found by Hone and his collaborators. The coupled of nonlinear equations is analyzed from the viewpoint of Lieâ€™s method of a continuous group of point transformations. Our results show the symmetries that the system of nonlinear equations can admit, as well as the admitting of the three-dimensional Lie algebra. Moreover, the Lie brackets for the independent vectors field are presented. Similarity reduction for the system is also discussed.
Long-term oral administration of transgenic rice containing cedar pollen T-cell epitopes potentially improves medication- and allergy-related quality-of-life scores
Authors: Endo Tomonori , Asaka Daiya , Nakayama Tsuguhisa , Saito Shota , Kodama Hiroki , Mitsuyoshi Ryoto , Sugimoto Naoki , Omae Sachiko , Takagi Hidenori , Wakasa Yuhya , Ozawa Kenjirou , Takano Makoto , Takaiwa Fumio , Kojima Hiromi , Saito Saburo
Published: June 2021

Background: We previously developed a transgenic rice that contains seven linked human predominant T-cell epitopes (7Crp) derived from Japanese cedar (JC) pollen allergens Cry j 1 and Cry j 2. Oral administration of 80 g of transgenic rice for 20 weeks suppressed allergen-specific
T-cell proliferation in participants with JC pollinosis, but their clinical symptoms did not improve. Objective: We examined the clinical efficacy of low-dose (5 g and 20 g) intake of the transgenic rice administered for two successive seasons. Methods:
In this randomized, double-blind, placebo controlled study, transgenic rice seeds (5 g or 20 g) were orally administered to the participants for 24 weeks in each of two successive JC pollen seasons. We analyzed T-cell proliferation and cytokine expression, and monitored symptom and medication
scores during the pollen season. Quality of life (QOL) was evaluated by using the Japanese Allergic Rhinitis Quality of Life Standard Questionnaire (JRQLQ). Results: Specific T-cell proliferation after stimulation with 7Crp, Cry j 1, and Cry j 2 was significantly suppressed
in the second JC pollen season. No significant differences were found among the three groups (5 g, 20 g, and placebo) with regard to clinical symptoms or medication scores in the first season. However, the medication scores and face scale for overall condition of JRQLQ improved in the 5-g
transgenic rice group in the second season, although careful re-examination with a large sample size is necessary to confirm the results. Conclusion: Low-dose oral administration of transgenic rice that contains 7Crp significantly reduced allergen-specific T-cell responses
and improved medication scores during the second season of administration. Thus, oral intake of the transgenic rice has the potential to induce immune tolerance to JC pollen allergens when administered for at least two successive seasons.
Effect of prenatal phthalate exposure on childhood atopic dermatitis: A systematic review and meta-analysis
Authors: Jung Minyoung , Kim Min-Ji , Kim Seonwoo , Kyung Yechan , Kim Minji , Lee Ji Young , Jeong Hye-In , Lee Bo Ra , Kim Jihyun , Ahn Kangmo , Park Yong Mean
Published: June 2021

Background: The association between prenatal exposure to phthalate and childhood atopic dermatitis (AD) has previously been investigated; however, the results are inconsistent. Objective: We aimed to perform a systematic review and meta-analysis of birth
cohort studies to investigate whether prenatal exposure to phthalate increases the risk of developing AD in children. Methods: We performed an electronic search of medical literature data bases. Studies were critically appraised, and a meta-analysis was performed.
Results: Among 129 articles identified, 11 studies met the eligibility criteria. Included studies originated from Europe (n = 5), the United States (n = 4), and Asia (n = 2). The study sample size ranged from 147 to 1024 mother-child pairs. Quality assessment by using the
Newcastle‐Ottawa scale of all the studies had scores of ≥6. A meta-analysis of data from eight selected studies suggested that monobenzyl phthalate (MBzP) exposure was significantly associated with the risk of AD development (odds ratio 1.16 [95% confidence interval, 1.04−1.31];
I2 = 17.36%). However, AD development was not associated with other phthalate metabolites, such as mono-(2-ethylhexyl) phthalate, monoethyl phthalate, mono-isobutyl phthalate, mono-n-butyl phthalate, and the sum of di-[2-ethylhexyl] phthalate on the development of AD (all p values
were > 0.05). Conclusion: Our meta-analysis suggested that prenatal exposure to phthalates may be associated with the development of childhood AD. However, further research is needed because only MBzP showed statistical significance and the number of articles in the
literature is still insufficient.
Etuaptmumk (Two-Eyed Seeing) and Ethical Space: Ways to Disrupt Health Researchers’ Colonial Attraction to a Singular Biomedical Worldview
Authors: Sinclaire Moneca , Schultz Annette , Linton Janice , McGibbon Elizabeth
Published: June 2021

Indigenous research on Turtle Island has existed for millennia, where knowledge(s) to work with the land and its inhabitants are available for next generations. These knowledge systems exist today but are rarely viewed as valid biomedical ‘facts’ and so are silenced. When Indigenous knowledge is solicited within health research, the knowledge system is predominantly an ‘add-on’ or is assimilated into Western understandings. We discuss disrupting this colonial state for nurse researchers. Two concepts rooted in Indigenous teachings and knowledges, Etuaptmumk (Two-Eyed Seeing) and Ethical Space, shed light on ways to disrupt health researchers’ attraction to a singular worldview which continue to privilege Western perspectives. Knowledge rooted in diverse knowledge systems is required to challenge colonial relations in health research and practice. A synergy between Etuaptmumk and Ethical Space can support working with both Indigenous and biomedical knowledge systems in health research and enhance reconciliation.
Moving beyond the rhetoric of social justice in nursing education
Authors: Garland Rachel , Batty Mary Lou
Published: June 2021

We argue that while the discipline of nursing aligns with the ideals of social justice and anti-racism, it has been challenging for nurse educators to translate these ideals into practice. In this discussion paper, we explore these challenges. Of note, there is little guidance for nurse educators to support student knowledge development in addressing the complex issues surrounding anti-racist and anti-discriminatory practice. Accordingly, we utilized Peggy Chinn’s Peace and Power framework as a guide to develop an anti-racist practice that is underpinned by critical pedagogy. Our aim is to provide teaching and learning strategies for nurse educators to address racism, discrimination, and oppression in undergraduate nursing learning environments. Implications of this article include guidance for nurse educators who are committed to anti-racist pedagogical practice.
Pelatihan Media Sensitif Gender bagi Penggiat Media Bersama DP3AP2KB Provinsi Jawa Tengah
Authors: Nuzuli Ahmad Khairul
Published: June 2021

Banyaknya kasus ketimpangan dan diskriminasi perempuan di dalam media sudah menjadi permasalahan baru bagi media di Indonesia. Maka oleh sebab itu perlu diadakannya pelatihan tentang media sensitif gender bagi awak media untuk peningkatan pengetahuan awak media akan sensitif gender dalam produk jurnalistik. Pengabdi adalah dosen ilmu komunikasi dan pengamat media. Dengan kepakaran di media massa dan komunikasi gender, pengabdi bekerjasama Dinas Pemberdayaan Perempuan Perlindungan Anak Pengendalian Penduduk dan Keluarga Berencana (DP3AP2KB) Provinsi Jawa Tengah menjadi fasilitator dalam Pelatihan Media Sensitif Gender bagi Penggiat Media di Provinsi Jawa Tengah. Acara ini dilakukan di lima kota, dan masing-masing kota memiliki 45 peserta. Para peserta mewakili berbagai elemen seperti jurnalis TV, jurnalis radio, jurnalis cetak, pers kampus, dan akademisi. Acara ini diharapakn bisa mengujudkan pemberitaan yang ramah gender dan meningkatkan pengetahuan para awak media akan pentingnya media sensitif gender.
Efektivitas model pembelajaran daring berbasis tiktok
Authors: Ardiyanti Handrini , Kustandi Cecep , Cahyadi Ani , Elihami Elihami , Pattiasina Petrus Jacob
Published: June 2021

In an effort to prevent the Covid-19 pandemic, schools are implementing online student learning methods. This government policy is in order to break the chain of spreading Covid-19. However, in practice, there are still many teachers in schools who are still confused about implementing the online learning system because the teachers are not good at technology, so the teacher only sends assignments without explaining the material. As a result, online learning becomes ineffective which has an impact on student learning outcomes. This study aims to determine the effectiveness of the tiktok-based online learning model. The method used in this research is phenomenology. The informants in this study were the parents of students who live in East Java. The conclusion of this study is that the Tik Tok application used as a learning medium has not been fully effective. Parents consider that the Tik Tok application used in their children's learning is mostly used for playing while learning hours are still in progress.

Keywords: model; learning; online; tik tok.

 

Dalam upaya mencegah pandemi Covid-19, sekolah menerapkan metode pembelajaran siswa secara online. Kebijakan pemerintah ini dalam rangka memutus mata rantai penyebaran Covid-19. Namun dalam prakteknya masih banyak guru di sekolah yang masih bingung menerapkan sistem pembelajaran online karena gurunya kurang jago teknologi, sehingga guru hanya mengirimkan tugas tanpa menjelaskan materi. Akibatnya pembelajaran online menjadi tidak efektif yang berdampak pada hasil belajar siswa. Penelitian ini bertujuan untuk mengetahui efektivitas model pembelajaran daring berbasis Tik Tok. Metode yang digunakan di dalam penelitian ini adalah fenomenologi. Informan dalam penelitian ini adalah orang tua siswa yang tinggal di Jawa Timur. Kesimpulan penelitian ini adalah bahwa aplikasi Tik Tok yang digunakan sebagai media pembelajaran belum sepenuhnya berjalan dengan efektif. Para orang tua menilai bahwa aplikasi Tik Tok yang digunakan dalam pembelajaran anak-anak mereka lebih banyak digunakan untuk bermain ketika jam pembelajaran masih berlangsung.

Kata kunci: model; pembelajaran; daring; tik tok.
Impact of @RaikuBeauty instagram campaign content on brand image
Authors: Octaviana Vanisha , Susilo Daniel
Published: June 2021

Most Indonesian women often feel insecure about their appearance without makeup. Raiku Beauty is here as one of the new beauty brands that motivates Indonesian women to be able to appear confident by taking care of their skin using skincare from Raiku. The purpose of this study was to determine whether the content on Instagram @RaikuBeauty related to the “Dare to be Bare” campaign was able to have a significant influence on the brand image. The theory used in this study is the content of communication messages on social media. This research is quantitative explanative with data collected through a survey to 395 respondents obtained from the Taro Yamane formula. The data obtained were then tested for hypotheses with simple linear regression. The results showed that there was a significant impact of social media content on the dare to be bare campaign on brand image, with 60.2% degree of impact.

Keywords: social media content; brand image; instagram; raiku beauty.
Discurso de artistas indígenas contemporâneos brasileiros
Authors: Ferreira Camargo Leticia
Published: June 2021

Este trabalho busca apresentar alguns dos muitos artistas indígenas contemporâneos brasileiros e como suas falas, músicas e lutas diárias se conectam intimamente às discussões sobre políticas linguísticas pró línguas indígenas no Brasil. A partir das falas dos artistas em entrevistas sobre suas motivações e experiências procuro fazer pontes com as discussões acadêmicas e teóricas sobre os processos de apagamento histórico das línguas e modos de ser indígena, e os projetos de resgate e revitalização destes na perspectiva dos estudos de políticas linguísticas. Apresento um breve histórico do embate entre a língua portuguesa e as línguas indígenas no Brasil, e alguns pontos das discussões sobre as relações entre novas tecnologias e povos originários. Os artistas e ativistas têm cada vez mais protagonizado suas lutas em seus próprios termos, e sendo a música uma arte acessível, eles têm levado suas línguas e práticas a espaços de onde eram historicamente excluídos. Considerando a importância do protagonismo dos sujeitos das próprias comunidades envolvidas nos debates e desenvolvimentos de iniciativas de políticas linguísticas, proponho que permaneçamos atentos à essa dimensão artística e seu poder de divulgação e revitalização de línguas indígenas.
Promising experimental hybrids of spring rapeseed (Brassica napus L.) for CMS-system of Polima type
Authors:   Lipetsk Rapeseed Research Institute – a branch of V.S. Pustovoit All-Russian Research Institute of Oil Crops, Pastukhov I.O. , Karpachyov V.V. ,   Lipetsk Rapeseed Research Institute – a branch of V.S. Pustovoit All-Russian Research Institute of Oil Crops
Published: June 2021

One of the prior directions in spring rapeseed breeding is development of heterotic hybrids. Seed growing of the most hybrids F1 used in production are often carried out by two types of cytoplasmic male sterility, they are polima and ogura. At the Lipetsk Rapeseed Research Institute, fertility restorers on sterile cytoplasm were made and estimated for the main valuable traits. The purpose of the research was to develop effective restorers, which are necessary for obtaining of highly productive hybrids on the Polima type cytoplasmic male sterility (CMS). The object of research was 56 varieties of Brassica napus L., which were selected in 2013. It is noted that hybrids F1 were more productive than the parental forms and the standards (the varieties Ratnik and Rif). The restorer line LHR-1 is of practical interest for the development of hybrids on the Polima CMS.
A linkage of gene of resistance to a broomrape race G with microsatellite loci of a sunflower linedonor RGP1 of VNIIMK’s breeding
Authors:   V.S. Pustovoit All-Russian Research Institute of Oil Crops (VNIIMK), Guchetl S.Z. , Savichenko D.L. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops (VNIIMK)
Published: June 2021

Broomrape (Orobanche cumana Wallr.) is one of the main biotic factors limiting high sunflower yield formation. The most effective and environmentally safe method of protection is cultivation of resistant varieties and hybrids of sunflower. Development of resistant sunflower genotypes includes search and usage of sources of resistance in breeding process as well as accurate and productive procedures of material assessment. The purpose of the research is to analyze a linkage of a gene Or7 with microsatellite loci of the line-donor of resistance to broomrape race G from the VNIIMK’s collection. The objects of the research are the line RGP1 – a donor of resistance to broomrape race G and a susceptible to this race line VR 678 from the VNIIMK’s collection. Sunflower plants were crossed in field to produce F1. Also we conducted self-pollination of F1 plants to obtain F2 progeny. Plants were tested in a greenhouse in soil infected with seeds of broomrape race G using a method of early diagnostic. Sunflower DNA was extracted from the top leaves of the young sprouts of the vegetative plants. For PCR-analysis we used three SSR-primers demonstrated polymorphism in parental lines: ORS 683, ORS 1040, and ORS 1112. We tested joint inheritance of the gene Or7 and these loci, and inheritance between SSR-loci. An independent inheritance of the gene Or7 with DNA-loci ORS 683, ORS 1040, and ORS 1112, as well as SSR-loci between ORS 1040 and ORS 1112, ORS 1040 and ORS 683 was showed. Loci ORS683 – ORS 1112 are linked with a frequency of recombination of 0.27 ± 0.41 (27 cM). As a result of our research location of the gene Or7 in the nearest area to microsatellite loci ORS 683, ORS 1040, and ORS 1112 was excluded. Basing on studied literary sources and a representative sunflower genome HanXRQr2.0-SUNRISE we made a partial physical map LG3 for determination of an area for the further search of a localization of the Or7 and DNAmarkers co-segregating with this gene.
The confectionary sunflower variety Karavan
Authors:   V.S. Pustovoit All-Russian Research Institute of Oil Crops (VNIIMK), Detsyna А.А. , Khatnyansky V.I. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops (VNIIMK), Illarionova I.V. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops (VNIIMK), Demurin Ya.N. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops (VNIIMK)
Published: June 2021

Confectionary sunflower variety Karavan was developed in V.S. Pustovoit All-Russian Research Institute of Oil Crops within a breeding program of development of the varieties of the different maturity groups, usage directions and resistant to stress factors. The variety Karavan belongs to mid-maturing group, possesses potentially high yield, is tolerant to a complex of broomrape races E, F, G. Plant height is 180– 190 сm. The new variety is characterized with high speed of growth at the initial stages of development. Thousand-seed weight is more than 140 g at recommended plant population. The variety Karavan is included into the State Registry of the breeding achievements of the Russian Federation since 2021 and permitted for production in the Central Black Soil (5), the Northern Caucasus (6), Middle Volga (7) and Low Volga (8) regions.
As principais causas que levam a automutilação em adolescentes: uma revisão integrativa
Authors: Oliveira Andressa de , Souza Sabrinna Barbosa de , Costa Nelzir Martins
Published: June 2021

Objetivo: Identificar os fatores causais em adolescentes que estimulam o aumento de casos de autolesão. Métodos: Tratou-se de uma revisão integrativa de literatura, de caráter qualitativa e descritiva. Foram selecionadas 40 bibliografias das plataformas Scientific Electronic Library Online (Scielo), PUBMED, Acervo+, Periódicos Eletrônicos em Psicologia (PePSIC) e Semantic Scholar dos últimos 6 anos, sendo apenas 15 literaturas aptas para a revisão a partir dos critérios de inclusão e exclusão. Resultados: Os principais fatores envolveram aspectos pessoais, familiares, transtornos psiquiátricos, relacionados à infância e risco sociais. Além do mais, identificou que os transtornos psiquiátricos e o uso inadequado da internet influenciam negativamente no comportamento autolesivo. Adolescentes que se automutilam não possuem a intenção consciente de cometer suicídio, mas sim uma forma de diminuir o seu sofrimento, apesar do ato ser um fator de risco para que isso ocorra. Considerações finais: Buscou-se conhecer as causas que justificam a automutilação entre esses jovens, que permite identificar de forma precoce e prevenir a ocorrência de novos casos. Além disso, é importante a quebra do tabu sobre automutilação entre jovens, informando profissionais da educação para combater a negligência em relação a este tema.
Os possíveis impactos do Sars-CoV-2 em gestantes e no desenvolvimento fetal: revisão narrativa
Authors: Souza Maria Eduarda Melo , Farias Ana Cláudia Ribeiro , Vieira Carlos Henrique França , Santana Felipe Santos , Silva Camila Pinheiro Santiago , Rosário Wilian Reis , Dias Tatielle Gomes , Pereira Domingos Magno Santos , Figueiredo Cristiane Santos Silva e Silva , Gonçalves Caroline Amélia
Published: June 2021

Objetivo: Entender, a partir de uma revisão narrativa, os possíveis impactos do SARS-CoV-2 nas gestantes e para o desenvolvimento fetal. Revisão bibliográfica: Constatou-se que a maioria das gestantes desenvolveu algum tipo de sintoma da doença e a sintomatologia apresentada foi diversa, sendo febre e tosse as mais comuns. A progressão da COVID-19 em gestantes está associada a um processo de coagulopatia, com a maior possibilidade do desenvolvimento de coágulos intravasculares disseminados nos espaços intervilosos da placenta afetando as trocas gasosas e de nutrientes entre mãe e feto. Exames laboratoriais revelam que a proteína C reativa pode estar aumentada, também os níveis elevados de enzimas hepáticas (TGO e TGP) e creatina fosfoquinase, dímero-D e troponina elevada. Não há informações consistentes para afirmar transmissão no binômio materno-fetal. Considerações finais: A sintomatologia de grávidas é semelhante à de não grávidas e não há evidências consistentes de infecção intrauterina causada por transmissão vertical em mulheres com SARS-CoV-2 no terceiro trimestre de gravidez.
Kawasaki disease; rare; or misdiagnosed: A case report in a tertiary hospital in Nigeria
Authors: Enyuma Callistus Achuri Okwuchukwu , Amajor Anthony Chimereze , Akpah Enobong Ufot , Brown-Abang Ekaete Samuel
Published: June 2021

Kawasaki disease (KD) is a self-limiting, acute febrile vasculitis with predilection for children under-5 years. Most reports have emanated from Japan with only a few cases reported in Africa. KD presents a diagnostic dilemma and a high index of suspicion is critical as early treatment reduces the incidence of complications. We describe a 5-month-old male infant who presented with classical clinical features though with delayed diagnosis. Received moderate dose aspirin with limitation of access to intravenous immunoglobulin and who did not develop coronary artery complication. The case report highlights the diagnostic challenges faced by practitioners, made worse by the low index of suspicion inherent in our setting. The fatal complications that may be associated with KD can, therefore, be avoided. It is hoped that pediatricians in particular would become conversant with the diagnostic criteria to facilitate early diagnosis and intervention in children.
Imaging in peripheral neuropathy: Ultrasound and MRI
Authors: Upadhyaya Vaishali , Choudur Hema Nalini
Published: June 2021

Peripheral neuropathy (PN) can be due to either entrapment or other causes such as trauma, infection, inflammation, and mass lesions. Evaluation of peripheral nerves was previously limited to history, clinical examination, and electrodiagnostic tests. However, now, with advances in imaging, both ultrasound (US) and magnetic resonance imaging (MRI) enable excellent evaluation of the peripheral nerves. US can be used for preliminary imaging of patients with PN and MRI can be done if US results are inadequate or equivocal.
Meningioma as the host for metastatic breast cancer: A rare occurrence with important therapeutic impact
Authors: Hosseinzadeh Mohammad , Ketabchi Seyed Mehdi , Ahmadi Seyed Ali , Hendi Kasra , Alimohamadi Maysam
Published: June 2021

Background:

Tumor-to-tumor metastasis is a rare condition. There are few reports of metastatic tumors within intracranial tumors, including meningiomas. Since some metastatic tumors have osteoblastic imaging pattern, it is not always easy to differentiate them from meningioma on preoperative studies.

Case Description:

A 60-year-old female referred to our center complaining about a progressive headache, nausea, and vomiting for the past month. She had a history of breast cancer treated with radical mastectomy (5 years ago) and adjuvant chemotherapy (until 1 year ago). Workups revealed a dural-based mass in the left temporobasal and midline subfrontal regions. Histopathological study showed breast cancer metastasis nests within the primary meningioma.

Conclusion:

As the diagnosis of metastatic nests inside a benign tumor, drastically alters postoperative adjuvant treatments, a high index of suspicion is needed evaluating tumors from patients with a history of systemic neoplasms.
Ganglioglioma of the cervicothoracic spinal cord in a patient with neurofibromatosis type 1: A case report
Authors: Cruz Thainá Zanon , Ferreira-Pinto Pedro Henrique Costa , Brito Ana Carolina Gonçalves , Ururahy Leandro , Sanchez Jefferson Trivino , Nigri Flavio
Published: June 2021

Background:

Gangliogliomas are rare tumors of the central nervous system. They are usually located intracranially and rarely in the spinal cord. There is no clear correlation between this tumor and neurofibromatosis type 1 (NF1) with only four cases described. The aim of this article is to describe one more case and add data to the literature regarding this rare association.

Case Description:

An 8-year-old boy with NF1 presented progressive asymmetrical paraparesis (Grade 4 medical research council scale on the right leg and Grade 3 on the left leg). The cervicothoracic spinal magnetic resonance imaging demonstrated an intramedullary lesion from C4 to T4 vertebrae. The patient underwent a microsurgical resection. A partial resection was performed due to a drop in the motor evoked potential signal amplitude during dissection. Pathology report revealed a ganglioglioma (World Health Organization Grade I). Postoperatively, the patient evolved with worsening of the paraparesis. A few weeks later, he has improved his preoperative functional neurological state (better strength and gait). Adjuvant radiotherapy was not used. The patient is being followed up at the neurosurgery outpatient clinic.

Conclusion:

This is another case of spinal ganglioglioma associated with NF1. The tumor must be included in the differential diagnosis of patients with NF1 and spinal lesions. Complete microsurgical resection remains the standard treatment for spinal gangliogliomas, however, in this specific case, it was decided to leave a portion of the tumor to prevent neurological damage. The prognosis and treatment of this condition associated with NF1 remains to be determined.
Pharyngeal perforation: A rare complication of occipitocervical injury
Authors: Vandenbulcke Alberto , Cossu Giulia , Coll Juan Barges
Published: June 2021

Background:

Atlantoaxial dislocation is a rare injury following high-energy trauma. We report an undescribed complication of atlantoaxial dislocation.

Case Description:

A 75-year-old man presented with atlantoaxial dislocation and Jefferson C1 fracture after a high-energy trauma. Occipitoaxial stabilizations were performed the day after. A nasopharyngeal fistula was identified at day 5 causing a persistent epistaxis.

Conclusion:

Nasopharyngeal fistulization of C1 bony fragment is a rare complication of complex occipitocervical injury. Combined treatment with ENT surgeon should be considered.
Orbitozygomatic approach for large orbital cavernous hemangioma
Authors: de Melo Junior Jose Orlando , de Castro Marcelo Francisco Alcantara Ribeiro , Landeiro Jose Alberto
Published: June 2021

Background:

Cavernous hemangiomas, more accurately defined as cavernous venous malformations, constitute the most common primary intraorbital tumors of adults comprising 4–9% of all tumors,[4] and the second most frequent cause of unilateral proptosis after thyroid-related orbitopathy.[3] Over 80% are located within the intraconal compartment, most commonly in the lateral aspect.[1] Surgical treatment for orbital cavernous hemangioma is generally required in symptomatic cases, optic nerve compression, and cosmetically disfiguring proptosis.[2] Transcranial approaches, the most familiar approaches for neurosurgeons, provide wide access to the entire superior and lateral orbit. They usually offer direct visualization, allowing for a safer dissection, while minimizing significant injury to the native neural and vascular anatomy of the orbit.[5] Although transcranial approaches continue to evolve, in many cases, they have been supplanted by endoscopic skull base approaches and modifications to deep lateral orbitotomy approaches.[5]

Case Description:

A 62-year-old male patient presented with slowly expanding left proptosis, which he had first noticed 3 years before presentation. He was already blind in his right eye due to a history of traumatic amaurosis in childhood. The left eye examination revealed severe proptosis with restricted eye movement in all directions and significant visual impairment (visual acuity of 20/300, expressed by Snellen test, with no improvement on correction). MRI of the orbit showed a large left superolateral intraconal cavernous hemangioma compressing and displacing the optic nerve, with the typical feature of slow gradual irregular enhancement with delayed washout on contrast-enhanced image. A one-piece modified orbitozygomatic approach was performed and a total en block resection was achieved. The bone flap was fixed with titanium miniplates and screws, the temporal muscle and the skin were closed in a standard fashion. The patient did not present any new deficit in the postoperative period. The patient had good functional and cosmetic outcomes with resolution of proptosis, restoration of eye movements, and improvement of visual acuity in the 3-month follow-up. Postoperative MRI showed total resection.

Conclusion:

The orbitozygomatic approach for large orbital cavernous hemangioma provides satisfactory orbital decompression and large working space, reduces traction, and increases visualization and freedom to dissect small vessels and nerves that may be tightly attached to the tumor pseudocapsule.
Perioperative dual antiplatelet therapy for patients undergoing spine surgery soon after drug eluting stent placement
Authors: Peeters Sophie M. , Nagasawa Daniel , Gaonkar Bilwaj , Niu Tianyi , Tucker Alexander , Attiah Mark , Babayan Diana , Moreland Natalie , Yang Isaac , Press Marcela Calfon , Macyszyn Luke
Published: June 2021

Background:

Performing emergent spinal surgery within 6 months of percutaneous placement of drug-eluting coronary stent (DES) is complex. The risks of spinal bleeding in a “closed space” must be compared with the risks of stent thrombosis or major cardiac event from dual antiplatelet therapy (DAPT) interruption.

Methods:

Eighty relevant English language papers published in PubMed were reviewed in detail.

Results:

Variables considered regarding surgery in patients on DAPT for DES included: (1) surgical indications, (2) percutaneous cardiac intervention (PCI) type (balloon angioplasty vs. stenting), (3) stent type (drug-eluting vs. balloon mechanical stent), and (4) PCI to noncardiac surgery interval. The highest complication rate was observed within 6 weeks of stent placement, this corresponds to the endothelialization phase. Few studies document how to manage patients with critical spinal disease warranting operative intervention within 6 months of their PCI for DES placement.

Conclusion:

The treatment of patients requiring urgent or emergent spinal surgery within 6 months of undergoing a PCI for DES placement is challenging. As early interruption of DAPT may have catastrophic consequences, we hereby proposed a novel protocol involving stopping clopidogrel 5 days before and aspirin 3 days before spinal surgery, and bridging the interval with a reversible P2Y12 inhibitor until surgery. Moreover, postoperatively, aspirin could be started on postoperative day 1 and clopidogrel on day 2. Nevertheless, this treatment strategy may not be appropriate for all patients, and multidisciplinary approval of perioperative antiplatelet therapy management protocols is essential.
Trigeminal neuralgia secondary to onyx embolization of a right occipital arteriovenous malformation
Authors: El Houshiemy Mohamad , Bsat Shadi Abdelatif , El Ghazal Ryan , Moussalem Charbel , Amine Ali , Kawtharani Sarah , Halaoui Adham , Assi Hazem , Darwish Houssein
Published: June 2021

Background:

Trigeminal neuralgia is a debilitating chronic condition characterized by severe recurrent hemifacial pain which is often caused by compression of the trigeminal nerve by an adjacent vessel loop. Microvascular decompression (MVD) surgery is an effective procedure that can lead to full symptomatic relief. Intracranial arteriovenous malformations (AVMs) are primarily congenital abnormalities that may be asymptomatic or manifest as seizures or focal neurologic deficits. They may cause intracranial bleeding and hence are promptly treated, often by endovascular embolization. This procedure is safe but may have a multitude of unpredictable complications.

Case Description:

A 33-year-old female presented with medically refractory trigeminal neuralgia secondary to Onyx embolization of a right occipital AVM 3 years prior. She underwent surgical exploration and MVD of the trigeminal nerve root which was found to be compressed by the previously embolized superior cerebellar artery. The procedure was successful and full symptomatic resolution was immediately achieved.

Conclusion:

Postprocedural trigeminal neuralgia is a procedural complication of Onyx endovascular embolization. It may be treated by MVD surgery regardless of the presence or absence of a compressive vascular loop on imaging.
Clinical presentation and management of hypophysitis: An observational study of case series
Authors: Karrou Marouan , Benyakhlef Salma , Alla Achwak , Messaoudi Najoua , Amar Asmae Oulad , Rouf Siham , Kamaoui Imane , Oulali Noureddine , Moufid Faycal , Abda Naima , Latrech Hanane
Published: June 2021

Background:

Hypophysitis is described as a rare chronic inflammatory affection of the pituitary gland. However, to date, its pathogenesis has not been completely cleared up. Clinical features are polymorphic, including symptoms related to inflammatory compression and/or hypopituitarism. Laboratory tests determine hormone deficiencies orientating replacement therapy’s protocol. MRI of the hypothalamic-pituitary region is crucial in exhibiting major radiological signs such as pituitary homogeneous enlargement and gland stalk’s thickening. The etiological diagnosis is still challenging without affecting the management strategy. Corticosteroids have widely been used but a close follow-up without any treatment has also been approved.

Case Description:

In this report, seven patients with hypophysitis have been collected over a period of 6 years. The average age of our patients was 32.1 years ± 11.8 with a female predominance (71.4%). Panhypopituitarism was objective in 42.9% of cases, a combined deficiency of the hypothalamic-pituitary thyroid, adrenal and gonadal axes in 28.6% of cases. A central diabetes insipidus was noted in 42.9% of the patients. Idiopathic hypophysitis was the most common etiology. The use of long course corticosteroids was required in 28.6% when compressive signs were reported.

Conclusion:

Hypophysitis remains a rare disease with nonspecific clinical and radiological patterns. Autoimmune origin seems to be the most frequent etiology. No guidelines have been established for hypophysitis management and the evolution is still unpredictable.
Ectopic intraconal orbital meningioma – A rare case report
Authors: Sharma Anil Kumar , Gandhoke Charandeep Singh , Misra Somen , Ravi Ashik , Gupta Rakesh Kumar , Gupta Surendra Kumar
Published: June 2021

Background:

Ectopic orbital meningiomas (OM) are a rare subset of OMs which are neither attached to the optic nerve sheath nor to the surrounding bone.

Case Description:

We report the case of a 65-year-old female who presented with a 1 year history of proptosis followed by visual loss and restricted right eye movements since 3 months. Radiology of the orbits was suggestive of intraorbital, intraconal, and heterogeneous contrast enhancing right eye lesion which was completely excised through supraorbital orbitotomy approach. Intraoperatively, the right optic nerve, though compressed, and displaced inferiorly, was free from the lesion. The final histopathological diagnosis was “Meningioma WHO Grade I.” At 3 months follow-up, patient’s vision in the right eye improved from perception of light positive to 6/12 and there was no evidence of recurrence.

Conclusion:

Rarity of ectopic OM, total surgical excision with an excellent postoperative visual outcome prompted us to report this case.
Üretici Koşullarında Pamukta (Gossypium hirsutum L.) Yaprak Döktürücü Uygulamasının Bazı Morfolojik Özellikler Üzerine Etkisi
Authors: KABAK Rıfkı , KAYNAK Mustafa Ali
Published: June 2021

Bu çalışma, üretici koşullarında yaprak döktürücü (defoliant) uygulamalarının pamuğun bazı morfolojik özelliklerine etkisini belirlemek amacıyla, Aydın ili Efeler, Koçarlı, Söke, Didim ve Germencik ilçelerinin köylerinde on üretici tarlasında, 2019 üretim yılında yapılmıştır. Çalışmada Gloria pamuk çeşidi materyal olarak kullanılmıştır. Deneme tesadüf parselleri deneme desenine göre yürütülmüştür. Çalışmada, defoliant uygulama öncesi toplam koza sayısı, açmış koza oranı ve toplam yaprak sayısı ile defoliant uygulama sonrası açmış koza sayısı ve açmış koza oranı, yeşil yaprak sayısı, bitki üzerinde kalan kuru yaprak sayısı, yaprak döküm oranı, pamuk nem içeriği ve çırçır randımanı özellikleri incelenmiştir. Denemede defoliant uygulama sonrası açmış koza oranı, pamuk nem içeriği özellikleri yönünden üretici uygulamaları arasında istatiksel olarak önemli farklılık olmadığı tespit edilmiştir.Denemede defoliant uygulama öncesi toplam koza sayısı, defoliant uygulama öncesi ve sonrası açmış koza sayısı, defoliant uygulama öncesi yaprak sayısı, defoliant uygulama sonrası bitki üzerinde asılı kalan yeşil yaprak ve kuru yaprak sayısı, defoliant uygulama sonrası yaprak döküm oranı ve çırçır randımanı, özellikleri yönünden üretici uygulamaları arasında istatistiksel olarak önemli farklılıklar olduğu tespit edilmiştir. Çalışmada, bazı üreticilerin defoliant uygulama işlemini gerektiği gibi yapmadığı saptanmıştır.
Immunophenotypic Markers Associated with Minimal Residual Disease Status and Outcome in Patients with Multiple Myeloma Undergoing Autologous Stem Cell Transplantation
Authors:   Multiprofessional Residency in Cancer Attention, Hospital Amaral Carvalho, Jaú, São Paulo, Brazil, G Missassi , MRV Ikoma-Colturato ,   Flow Cytometry Laboratory, Hospital Amaral Carvalho, Jaú, São Paulo, Brazil, CM Bortolucci ,   Flow Cytometry Laboratory, Hospital Amaral Carvalho, Jaú, São Paulo, Brazil, JE Conte-Spilari ,   Flow Cytometry Laboratory, Hospital Amaral Carvalho, Jaú, São Paulo, Brazil, AJ Simioni ,   Bone Marrow Transplantation Service, Hospital Amaral Carvalho, Jaú, São Paulo, Brazil, MP Souza ,   Bone Marrow Transplantation Service, Hospital Amaral Carvalho, Jaú, São Paulo, Brazil, VAR Colturato ,   Bone Marrow Transplantation Service, Hospital Amaral Carvalho, Jaú, São Paulo, Brazil
Published: June 2021

Multiple Myeloma (MM) is one of the most common hematologic malignancies, with a heterogeneous prognosis. Therefore, the recognition of biomarkers can be useful to understand the differences in patient outcomes. Minimal Residual Disease (MRD) has been considered a very important prognostic factor in MM. In parallel, the prognostic value of immunophenotypic markers expressed in MM Plasma Cells (PCs) has also been described. The aim of this study was to assess the impact of CD27, CD28, CD45, CD56, CD117 and β2-microglobulin expressions on the outcome of 154 MM patients undergoing Autologous Stem Cell Transplantation (ASCT). The relation of each marker studied with the Overall Survival (OS) and Progression-Free Survival (PFS) was assessed, alone and in association with pre-ASCT MRD. Scores of good (GPM) and poor Prognostic Markers (PPM) were established, according to their respective survival curves. The expressions of CD27 and CD45 were associated to longer OS (p=0.013 and p=0.00, respectively) and PFS (p=0.00) as well as the absence of CD28 (OS p=0.026; PFS p=0.001) and CD56 (OS p=0.004; PFS p=0.009), in patients with undetectable MRD. The number of GPM showed an inverse correlation with the level of MRD (p=0.04), while a higher number of PPM was observed in patients with higher levels of MRD (p=0.04), which were also significantly associated with OS and PFS. In conclusion, although pre-ASCT MRD is a powerful prognostic factor in MM, these biomarkers can provide additional prognostic information and be used in the follow-up of MM patients.
Cytokines and miRNAs in the Pathogenesis of Rheumatoid Arthritis: A Review
Authors:   Department of Orthopaedics, Affiliated Hospital 2 of Nantong University, Nantong, Jiangsu, China, Z Yu , Y Hu ,   Department of Orthopaedics, Affiliated Hospital 2 of Nantong University, Nantong, Jiangsu, China, H Liu ,   School of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu, China, J Fan ,   Department of Orthopaedics, Affiliated Hospital 2 of Nantong University, Nantong, Jiangsu, China, W Liu ,   Department of Orthopaedics, Affiliated Hospital 2 of Nantong University, Nantong, Jiangsu, China
Published: June 2021

Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by inflammatory synovial hyperplasia. The pathogenesis of RA may be related to heredity, infection and sex hormones. The initial stage of RA involves the activation of T cells. Immature CD4+ T cells differentiate into T helper (Th) cells and T regulatory (Treg) cells under antigen stimulation and cytokine signal transduction. Cytokines secreted by Th cells and Treg cells play crucial roles in the pathophysiology of RA. The cytokines can be roughly divided into proinflammatory cytokines, anti-inflammatory cytokines, and both pro- and antiinflammatory cytokines. The imbalance between pro-inflammatory cytokines and anti-inflammatory cytokines would lead to a variety of autoimmune diseases. The disease severity was significantly indicated by serum or plasma cytokine levels with RA patients. Many clinical trials have shown that anticytokine drugs are effective in treating RA. This article reviews the differentiation process of different Th cells and Treg cells, the roles of cytokines secreted by them in the pathogenesis of RA and how miRNAs mediate immune regulation in RA. By understanding the roles of cytokines and miRNAs in the pathogenesis of autoimmunity, it is necessary to develop potential anti-cytokine drugs and biomarkers/therapeutic targeted drugs through various ways in the treatment of RA.