bluuebunny/crossref_metadata_2025 huggingface dataset:
Constructive Logic is Connexive and Contradictory
Authors: Wansing Heinrich
Published: January 2024

It is widely accepted that there is a clear sense in which the first-order paraconsistent constructive logic with strong negation of Almukdad and Nelson, QN4, is more constructive than intuitionistic first-order logic, QInt. While QInt and QN4 both possess the disjunction property and the existence property as characteristics of constructiveness (or constructivity), QInt lacks certain features of constructiveness enjoyed by QN4, namely the constructible falsity property and the dual of the existence property.
This paper deals with the constructiveness of the contra-classical, connexive, paraconsistent, and contradictory non-trivial first-order logic QC, which is a connexive variant of QN4. It is shown that there is a sense in which QC is even more constructive than QN4. The argument focuses on a problem that is mirror-inverted to Raymond Smullyan’s drinker paradox, namely the invalidity of what will be called the drinker truism and its dual in QN4 (and QInt), and on a version of the Brouwer-Heyting-Kolmogorov interpretation of the logical operations that treats proofs and disproofs on a par. The validity of the drinker truism and its dual together with the greater constructiveness of QC in comparison to QN4 may serve as further motivation for the study of connexive logics and suggests that constructive logic is connexive and contradictory (the latter understood as being negation inconsistent).
AXIS MUNDI JAKO KLUCZ INTERPRETACYJNY TEOLOGII MAŁYCH OJCZYZN FRANCISZKA MANTHEYA
Authors: Babiński Jarosław
Published: January 2024

Mircea Eliade wprowadził w przestrzeń badań religioznawczych pojęcie axis mundi. Oznacza ono przyjęcie istnienia świętego, niezmiennego „centrum” – stałego punktu odniesienia, warunkującego postrzeganie i interpretowanie świata. Łączy ono różne wymiary rzeczywistości i daje jej całościową wizję. Axis mundi jest utożsamiane z wieloma elementami świata. Najczęściej jest nim dom – rozumiany jako miejsce narodzin, zamieszkania i rozwoju. Takie ujęcie pozwala odnieść tę kategorię do poglądów Franciszka Mantheya i stworzyć spójną wizję jego teologii małych ojczyzn.
„DOBRZE DZIAŁAĆ” I „DOBRZE ŻYĆ” – CNOTY JAKO TRWAŁY FUNDAMENT LUDZKIEGO DZIAŁANIA
Authors: Gliniecki Wojciech
Published: January 2024

Człowiek kieruje się w stronę jakiegoś dobra − cel działania. W naszej pracy skupimy się na stronie praktycznej ludzkiej egzystencji analizując następującą problematyką: w jaki sposób można kierować owym działaniem, aby realizować dobro właściwe tylko człowiekowi? Jakie warunki pozwalają człowiekowi możliwie najpełniej żyć zgodnie z wymaganiami prawa moralnego? W tym celu analizujemy cnoty rozumiane jako konkretne dyspozycje, które ukierunkowują człowieka na dobro i wyznaczają pewne imperatywy działania ludzkiego. Dochodzimy do wniosku, że cnoty pozwalają się człowiekowi rozwijać i afirmować jego specyfikę pośród innych stworzeń. Jest ona stałą sprawnością, która kieruje działanie i angażuje władze typowe dla człowieka: świadomości, rozumu i wolnej woli. Pozwala nie tylko dobrze działać, ale również dobrze żyć. W oparciu o personalistyczne ujęcie bytu człowieka stwierdzamy, iż cnota utożsamia się z dobrem moralnym i w ten sposób pomaga określić sens obiektywny tego działania.
PRAWDA W SŁUŻBIE DOBROCI. PRZYPADEK RACHAB I SZPIEGÓW (JOZ 2,12–14)
Authors: Szamocki Grzegorz
Published: January 2024

Artykuł prezentuje dociekania i analizy dokonane w celu interpretacji prośby Rachab o „znak prawdy” w Joz 2,12–14. Badania polegają na literackiej, semantycznej i teologicznej analizie biblijnego tekstu w jego perspektywie synchronicznej i diachronicznej. Prawda, o której mowa w Joz 2,12–14, jest prawdą o JHWH objawioną Izraelitom i przez nich doświadczoną, a poznaną przez Rachab. Znakiem przekonania o niej i jej przyjęcia jest okazywanie dobroci. Tak motywowaną dobroć Rachab okazała izraelskim szpiegom i o taką dobroć prosiła ona szpiegów dla siebie i swojej rodziny.
Concentrating solutions for a biharmonic problem with supercritical growth
Authors: Liu Zhongyuan
Published: January 2024

In this paper we consider the following supercritical biharmonic problem:
$$
\begin{cases}
\Delta^2 u= K(x)u^{p+\epsilon}&\text{in } \Omega,\\
u> 0 &\text{in }\Omega,\\
u=\Delta u=0&\text{on }\partial\Omega,
\end{cases}
$$
where $K(x)\in C^3(\overline{\Omega})$ is a nonnegative function,
$p=({N+4})/({N-4})$, $\epsilon> 0$, $\Omega$ is a smooth bounded domain
in $\mathbb{R}^N$, $N\geq6$. We show that, for $\epsilon$ small enough,
there exists a family of concentrating solutions under certain assumptions
on the critical points of the function $K(x)$.
Balanced capacities
Authors: Radul Taras
Published: January 2024

We consider capacity (fuzzy measure, non-additive probability) on a compactum
as a monotone cooperative normed game. Then it is natural to consider probability
measures as elements of core of such game.
We prove a topological version of the Bondareva-Shapley theorem
that non-emptiness of the core is equivalent to balancedness of the capacity.
We investigate categorical properties of balanced capacities and give
characterizations
of some fuzzy integrals of balanced capacities.
Multiple mixed interior and boundary peaks synchronized solutions for linearly coupled Schrödinger systems
Authors: Jin Ke
Published: January 2024

In the present paper we consider the problem:
\begin{equation} \label{0}\tag{N$_\varepsilon$}
\begin{cases}
-\varepsilon^{2}\Delta u+u=u^{3}+\lambda v& \text{in } \Omega, \\
-\varepsilon^{2}\Delta v+v=v^{3}+\lambda u& \text{in } \Omega,\\
u> 0,\ v> 0& \text{in } \Omega,\\
\dfrac{\partial u}{\partial n}=\dfrac{\partial v}{\partial n}=0& \text{on }
\partial\Omega,
\end{cases}
\end{equation}
where $\varepsilon> 0$, $0< \lambda< 1$, $\Omega\subset\mathbb{R}^{3}$ is
smooth and bounded, and $n$ denotes the outer normal vector defined
on $\partial\Omega$, the boundary of $\Omega$. By the Lyapunov-Schmidt reduction
method and the maximum principle of elliptic equations, we construct synchronized
solutions of (\ref{0}) with mixed interior and boundary peaks for any
$0< \varepsilon< \varepsilon_0$ and $\lambda\in(0,1)\backslash\{\lambda_0\}$,
where $\lambda_0\in(0,1)$ is given and $\varepsilon_0> 0$ is sufficiently small.
As $\varepsilon$ approaches $0$, the interior peaks concentrate at sphere packing
points in $\Omega$ and the boundary peaks concentrate at the critical points
of the mean curvature function of the boundary.
Periodismo y Nuevos Medios. Perspectivas y retos
Authors: Miranda Galbe Jorge
Published: January 2024

Reseña del libro “Periodismo y Nuevos Medios. Perspectivas y retos”, coordinado conjuntamente por Joaquín Sotelo González y Santiago Martínez Arias, docentes e investigadores de la Universidad Complutense de Madrid.
Development of a five-tier diagnostic test instrument to identify the level of understanding and misconceptions on the subject of equilibrium of rigid bodies at SMA Negeri 9 Jambi City
Authors: Simatupang Putri Handayani , Maison Maison , Hidayat M.
Published: January 2024

This research aims to identify students' misconceptions regarding website-based rigid body equilibrium material at SMA Negeri 9, Jambi City. This research focuses on developing a diagnostic paper-based test (PBT) in the form of a website. This research method is R&D (Research and Development) development with the ADDIE (analysis, design, development, implementation, evaluation) development model. However, this research has only reached the implementation stage. The instruments used in the research were the results of media questionnaires, instrument validation, and student responses. The research results are as follows: First, Dreamweaver, MySQL, and HTML can be used in website development. Second, the results of this product development can be used because they have been validated by media experts, namely Validator One and Validator 2, to determine the feasibility of the product being developed. Thus, a five-tier diagnostic test in the form of a paper-based test has been successfully developed into a website with a suitable category for identifying misconceptions among students regarding the equilibrium of rigid bodies.
Development of an Android-based physics e-module on the subject of elasticity in high school physics learning
Authors: Gola Nofefta , Subiki Subiki , Nuraini Lailatul
Published: January 2024

The research aims to analyze the validity and effectiveness of the Android-based physics e-module. This type of research is Research and Development (R&D) with a Nieveen development research design consisting of preliminary research, prototyping stage, and assessment stage. The research was carried out at Ngoro Jombang State High School. The research subjects were class XI MIPA 1 students for the 2021/2022 academic year. The results of the research show that the validity of the android-based physics e-module received a score of 89% and was considered very valid, while the effectiveness of the android-based physics e-module was based on the N-gain test with a value of 0.52, which shows the physics e-module android-based is effective in the medium category for use in the physics learning process.
Emotion Detection for Health and Well-being in Short Messaging Systems
Authors: Ogbuju Emeka
Published: January 2024

The exposure to unpleasant emotions or content in messages can lead to health complications, including high blood pressure and several heart-related disorders. Hence, the identification of unpleasant emotions in written content can serve as a beneficial instrument in addressing certain health-related issues. Emotions can be communicated through diverse modalities, including written text, spoken language, and facial gestures. The objective of this work is to create a Text-based emotion detection system that possesses the capability to accurately identify emotions within text messages. The use of message filtering mechanisms that detect and block content containing negative emotions can serve as a preventive measure to shield users from accessing messages that have the potential to adversely impact their well-being. Conversely, messages that convey positive or neutral emotions remain accessible for comprehension. In order to accomplish this objective, a combination of three machine learning algorithms, namely Naive Bayes, Support Vector Machine, and Logistic Regression, were employed, adhering to the CRISP-DM approach. The Logistic Regression technique achieved the greatest accuracy rate of 98.4% and was employed in the construction of the detection system. The Graphical User Interface (GUI) of the system was developed utilizing HTML and CSS, with the integration of diverse components to establish a comprehensive and operational interface for the user.
Patient Experience Management as a Tool for Internationalization in Foundation Cardiovascular of Colombia
Authors: León-Becerra Juan , Martinez Sanchez Jorge , Morales Adarme Andres
Published: January 2024

Medical tourism, also known as healthcare tourism or medical travel, refers to traveling to a foreign country to receive medical treatment. Medical tourism has recently become increasingly popular, with millions traveling abroad for healthcare services yearly. However, medical tourism is not without its challenges. Patients must carefully research and select healthcare providers and facilities, considering factors such as accreditation, quality of care, and patient safety. Patients may also face cultural and language barriers when seeking treatment in a foreign country. The present work aims to establish the bases and knowledge to determine the importance of patient satisfaction as a factor of competitiveness. This work presents a study case centralized in the institutions providing health services (IPS in Spanish): Cardiovascular Foundation of Colombia (FCV) and a detailed analysis of the internationalization processes established by the Cardiovascular Foundation. For this, each of the processes was categorized and detailed in such a way that it would allow identifying which are the determining factors in the patient's experience and how to improve them. Each proposed strategy consists of a theoretical framework of the topic to be developed, objectives, approach, methodology, and development. Finally, the results obtained are the product of the analysis of surveys applied to the objective users, theoretical verifications, interviews, and work groups with directors of the Cardiovascular Foundation of Colombia.
Determining The Optimal Milk Distribution Route Using The Ant Colony Optimization Method on Milk Industry
Authors: Hakim Gusti Mohamad Lukman , Aryanny Enny
Published: January 2024

A good distribution system will ensure the availability of products or goods needed by the community. The objective of this research is to identify the most efficient route for distributing UHT milk on Milk Industry, with the goal of minimizing the overall distance traveled during distribution. The contribution of this study is to determine the optimal distribution route for UHT milk on Milk Industry. Data analysis or data calculation is done using Ant Colony optimization. The independent variables used are the initial distribution route data of the company, agent location data, product demand data, and distance data between agents. The results of this study found that the company's route resulted in a total route distance of 251.95 km while for the optimal total distance Ant Colony Optimization method is the total route distance of 230.2 km. Thus, the optimal route of the distribution of Ant Colony Optimization method is better than the initial route of the company with a total route distance savings of 21.75 km with a percentage of savings of 8.63%.
A PROPÓSITO DE DUAS CONSTRUÇÕES DO PORTUGUÊS: ABORDAGEM CONSTRUCIONAL E ENSINO DE LÍNGUA / ABOUT TWO CONSTRUCTIONS OF PORTUGUESE: CONSTRUCTIONAL APPROACH AND LANGUAGE TEACHING
Authors: Oliveira Mariangela Rios de , Machado Marcello Martins
Published: January 2024

Neste artigo, adotando os pressupostos teóricos funcionalistas aliados à abordagem construcional da gramática, com base em Traugott e Trousdale (2013), Hilpert (2014) e Rosário e Oliveira (2016), entre outros, descrevemos e analisamos duas construções do português, integrantes de dois níveis gramaticais distintos, formadas a partir do nome “propósito”. A primeira tem função adjuntiva circunstancial, codificada como [a propósito de X], e a outra atua na marcação do discurso, no formato [a propósito]. A partir de metodologia basicamente qualitativa e de coleta de dados em fontes documentais do português contemporâneo, levantamos, descrevemos e analisamos contrastivamente essas duas construções, em termos de seus fatores de produtividade, esquematicidade e composicionalidade, de sua dimensão e de sua funcionalidade. Constatamos que [a propósito de X] tem maior instanciação no uso, é mais virtual e mais composicional, atuando no eixo sintático da língua; de outra parte, [a propósito] é menos produtiva, totalmente especificada e menos composicional, com função pragmático-discursiva. Refletimos acerca dos resultados obtidos à luz dos objetivos fixados para o ensino de português na Educação Básica do Brasil, como referidos nos Parâmetros Curriculares Nacionais (BRASIL, 1998) e na Base Nacional Comum Curricular (BRASIL, 2018); segundo estes objetivos, as tarefas de análise e reflexão sobre a língua devem ter o texto como o ponto central na sala de aula. Assim, conhecer pareamentos como os dois contemplados neste artigo pode contribuir para o sucesso das tarefas referidas.
The Increasing Suicide Rate of University Students in Bangladesh: A Sociological Investigation
Authors:   Department of Sociology and Social Policy, Lingnan University, Hong Kong, Hussain Rase ,   Department of Sociology, East West University, Dhaka-1212, Bangladesh, Shova Tahmina Yesmin ,   Department of Philosophy, University of Sheffield, UK,   Department of Philosophy, University of Dhaka, Dhaka-1000, Bangladesh
Published: January 2024

Suicide is not a freshly emerging problem in modern society; rather, it is adangerously developing social truth that is becoming more and more important to study as time goes on due to people's increased interest in more basic questions. Thecurrent study offers a normative and evaluative explanation of establishing the theory of moral goodness of suicidal intervention on sociological, philosophical,categorical imperatives, and humanist grounds because the suicide rate among university students has been sharply rising in recent years. Following the claims ofsociologists such Durkheim and philosophers likes Kant in regards to human integration, control, ethics, and integrity, a break in a person's suicide choice wouldbe a reason to reconsider. This study intends to critically analyze the patterns andcauses of suicide among Bangladeshi tertiary students by using secondary data analysis and the case study approach. We will argue that suicide elevates the responsibilities and accountability of academic institutions, families, governments,and the general public, necessitating special consideration. Keywords: Suicide, Reasoning, Solution, Socio-philosophical Facts, UniversityStudents, Bangladesh.
Parental Acceptance and LGBT Community Connectedness as Predictors of Outness Among Filipino Queer Young Adults
Authors:   Colegio de San Juan de Letran-Manila, Philippines, Marquez Stephany Louise A. , Mandap Gian Maverick ,   Colegio de San Juan de Letran-Manila, Philippines, Deg-Aoan Norman Paul ,   Colegio de San Juan de Letran-Manila, Philippines
Published: January 2024

The study aims to investigate how parental acceptance and LGBT community connectedness predict the act of coming and being out, or outness, among Filipino queer adults. A sample of 74 Filipino people identifying as lesbian, gay, and bisexual, aged 23-40 years old, who are in a romantic relationship, and are in contact with both parents, were surveyed. Multilinear regression analysis was used to determine if parental acceptance and LGBT community connectedness predicted outness. We found that the regression model is significant (F[2.72] = 7.872, p < .001). Moreover, parental acceptance is a significant predictor of outness (β = 0.421; p <. 001) whereas LGBT community connectedness was found to not be (β = 0.053; p = 0.629). Therefore, it can be inferred that parental acceptance is more important on the outness of Filipino queer adults than LGBT community connectedness. Keywords: Parental acceptance, LGBT community, Outness, Filipino, Young adults
Prediction of Maize Yield and Assessment of the Material Circularity of Maize Residues Used in the Dairy Cattle Feed Production
Authors:   Technology and Informatics Institute for Sustainability, National Metal and Materials Technology Center, National Science and Technology Development Agency, Pathum Thani, 12120, Thailand, Poolsawad Nongnuch
Published: January 2024

The dairy cattle industry is expanding rapidly to accommodate the growing demand for human consumption. This results in high cattle feed production. This study aims to forecast the amount of maize residue and calculate the circularity level of using maize residue as a feedstock for total mixed ration feed production in dairy cattle feed production. The multiple linear regression analysis is performed to predict maize yields in Thailand so that maize residues can be calculated and used in feed production. The material circularity indicator is also used with biological cycles to assess the circularity level of dairy cattle feed production under the circular economy concept. The results show that the maize yield is expected to increase, resulting in more maize residues. The use of maize residues in daily cattle feed production gives the MCI value of 0.6038, representing a high degree of circularity and explaining the sustainable management of wastes in the cattle feed industry. Moreover, using maize residues as a part of feed ingredients instead of the Napier grass saves the cost by 14.2%. The study results provide a guideline for farmers and related authorities to plan for managing maize residue in daily cattle feed production to lower operation costs and minimize environmental problems. Keywords: Biological cycle, Circular economy, Dairy cattle feed production, Maize residues, Material circularity indicator, Multiple linear regression
Erythrodermic mycosis fungoides: A case report
Authors: Xu Wu-Bing , Zhang Ya-Ping , Zhou Su-Ping , Bai Hao-Yang
Published: January 2024

BACKGROUND

Mycosis fungoides is the most common primary cutaneous T-cell lymphoma, whereas generalized erythroderma is rare. In this report, we describe a case of mycosis fungoides with generalized erythroderma using complete clinical data and [18F]fluoroDglucose positron emission tomography/computed tomography (18F-FDG PET/CT) images.

CASE SUMMARY

Systemic skin redness with desquamation for three years confirmed mycosis fungoides within one month. The patient underwent left axillary lymphadenectomy biopsy; pathological biopsy suggested abnormal T-cell lesions consistent with mycosis fungoides involving lymph nodes. The patient received methotrexate, 5 mg twice weekly, as part of their chemotherapy regimen. Patients January half after discharge, no obvious cause of high fever, left axillary lymph nodes with red heat pain, and rupture entered our hospital for treatment.

CONCLUSION

The 18F-FDG PET/CT is essential for early diagnosis and timely treatment.
Azacitidine maintenance therapy for blastic plasmacytoid dendritic cell neoplasm allograft: A case report
Authors: Tao Li-Li , Wen Hui-Ting , Wang Zi-Yi , Cheng Juan , Zhao Li
Published: January 2024

BACKGROUND

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, highly invasive malignant neoplasm. There is no universally accepted standard of care because of its rarity and the dearth of prospective research. It is still challenging for some patients to achieve persistent clinical remission or cure, despite the success of allogeneic hematopoietic stem cell transplantation (allo-HSCT), indicating that there is still a significant recurrence rate. We report a case of prevention of BPDCN allograft recurrence by azacitidine maintenance therapy and review the relevant literature.

CASE SUMMARY

We report a 41-year-old man with BPDCN who was admitted to hospital due to skin sclerosis for > 5 mo’ duration. BPDCN was diagnosed by combined clinical assessment and laboratory examinations. Following diagnosis, the patients underwent induction consolidation chemotherapy to achieve the first complete remission, followed by bridging allo-HSCT. Post-transplantation, azacitidine (75 mg/m2 for 7 d) was administered as maintenance therapy, with repeat administration every 4–6 wk and appropriate extension of the chemotherapy cycle. After 10 cycles, the patient has been disease free for 26 mo after transplantation. Regular assessments of bone marrow morphology, minimal residual disease, full donor chimerism, Epstein–Barr virus, and cytomegalovirus all yielded normal results with no abnormalities detected.

CONCLUSION

Azacitidine may be a safe and effective maintenance treatment for BPDCN following transplantation because there were no overt adverse events during the course of treatment.
Subarachnoid hemorrhage misdiagnosed as acute coronary syndrome leading to catastrophic neurologic injury: A case report
Authors: Lin Jun-Ming , Yuan Xiao-Jun , Li Guang , Gan Xin-Rong , Xu Wen-Hua
Published: January 2024

BACKGROUND

Elevated levels of cardiac troponin and abnormal electrocardiogram changes are the primary basis for clinical diagnosis of acute coronary syndrome (ACS). Troponin levels in ACS patients can often be more than 50 times the upper reference limit. Some patients with subarachnoid hemorrhage (SAH) also show electrocardiogram abnormalities, myocardial damage, and elevated cardiac biomarkers. Unlike ACS patients, patients with SAH only have a slight increase in troponin, and the use of anticoagulants or antiplatelet drugs is prohibited. Because of the opposite treatment modalities, it is essential for clinicians to distinguish between SAH and ACS.

CASE SUMMARY

A 56-year-old female patient was admitted to the emergency department at night with a sudden onset of severe back pain. The final diagnosis was intraspinal hematoma in the thoracic spine. We performed an emergency thoracic spinal canal hematoma evacuation procedure with the assistance of a microscope. Intraoperatively, diffuse hematoma formation was found in the T7-T10 spinal canal, and no obvious spinal vascular malformation changes were observed. Postoperative head and spinal magnetic resonance imaging (MRI) showed a small amount of SAH in the skull, no obvious abnormalities in the cervical and thoracic spinal canals, and no abnormal signals in the lumbar spinal canal. Thoracoabdominal aorta CT angiography showed no vascular malformation. Postoperative motor system examination showed Medical Research Council Scale grade 1/5 strength in both lower extremities, and the patient experienced decreased sensation below the T12 rib margin and reported a Visual Analog Scale score of 3.

CONCLUSION

Extremely elevated troponin levels (more than 50 times the normal range) are not unique to coronary artery disease. SAH can also result in extremely high troponin levels, and antiplatelet drugs are contraindicated in such cases. Emergency MRI can help in the early differential diagnosis, as a misdiagnosis of ACS can lead to catastrophic neurological damage in patients with spontaneous spinal SAH.
Evaluating combined bevacizumab and XELOX in advanced colorectal cancer: Serum markers carcinoembryonic antigen, carbohydrate antigen 125, carbohydrate antigen 199 analysis
Authors: Zhou Dong-Bing , Cheng Jun , Zhang Xiong-Hui
Published: January 2024

BACKGROUND

Colorectal cancer ranks third and second among common and fatal cancers. The treatment of metastatic colorectal cancer (mCRC) is generally based on XELOX in clinical practice, which includes capecitabine (CAP) and oxaliplatin. Serum tumor markers carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 125 and CA199 are prognostic factors for various tumors.

AIM

To investigate evaluating combined bevacizumab and XELOX in advanced colorectal cancer: Serum markers CEA, CA125, CA199 analysis.

METHODS

In this retrospective study, a total of 94 elderly patients diagnosed with mCRC were recruited and subsequently categorized into two groups based on the distinct treatment modalities they received. The control group was treated with XELOX plus CAP (n = 47), while the observation group was treated with XELOX plus CAP and BEV (n = 47). Several indexes were assessed in both groups, including disease control rate (DCR), incidence of adverse effects, serum marker levels (CEA, CA125, and CA19) and progression-free survival (PFS).

RESULTS

After 9 wk of treatment, the serum levels of CEA, CA199 and CA125 in the observation group were significantly lower than those in the control group (P < 0.05). Moreover, the PFS of the observation group (9.12 ± 0.90 mo) was significantly longer than that of the control group (6.49 ± 0.64 mo). Meanwhile, there was no statistically significant difference in the incidence of adverse reactions and DCR between the two groups during maintenance therapy (P > 0.05).

CONCLUSION

On the basis of XELOX treatment, the combination of BEV and CAP can reduce serum tumor marker levels and prolong PFS in patients with mCRC.
Changes in macrophage infiltration and podocyte injury in lupus nephritis patients with repeated renal biopsy: Report of three cases
Authors: Liu Shi-Yuan , Chen Hao , He Li-Jia , Huang Chun-Kai , Wang Pu , Rui Zhang-Ru , Wu Jue , Yuan Yang , Zhang Yue , Wang Wen-Ju , Wang Xiao-Dan
Published: January 2024

BACKGROUND

In this study, we retrospectively analysed macrophage infiltration and podocyte injury in three patients with diffuse proliferative lupus nephritis (LN) who underwent repeated renal biopsy.

CASE SUMMARY

Clinical data of three diffuse proliferative LN patients with different pathological characteristics (case 1 was LN IV-G (A), case 2 was LN IV-G (A) + V, and case 3 was LN IV-G (A) + thrombotic microangiopathy) were reviewed. All patients underwent repeated renal biopsies 6 mo later, and renal biopsy specimens were studied. Macrophage infiltration was assessed by CD68 expression detected by immunohistochemical staining, and an immunofluorescence assay was used to detect podocin expression to assess podocyte damage. After treatment, Case 1 changed to LN III-(A), Case 2 remained as type V LN lesions, and Case 3, which changed to LN IV-S (A), had the worst prognosis. We observed reduced macrophage infiltration after therapy. However, two of the patients with active lesions after treatment still showed macrophage infiltration in the renal interstitium. Before treatment, the three patients showed discontinuous expression of podocin. Notably, the integrity of podocin was restored after treatment in Case 1.

CONCLUSION

It may be possible to reverse podocyte damage and decrease the infiltrating macrophages in LN patients through effective treatment.
Primary acinic cell carcinoma of the breast: A case report and review of literature
Authors: Ding Jia-Sheng , Zhang Min , Zhou Fang-Fang
Published: January 2024

BACKGROUND

In the current World Health Organization classification, acinic cell carcinoma (AcCC) of the breast is considered a rare histological subtype of triple-negative breast cancer. Because of the few reports in the literature, data concerning clinical outcomes are limited. Here, we report a case of AcCC of the breast in a 48-year-old woman.

CASE SUMMARY

A 48-year-old woman with a mass in her right breast came to our hospital for further diagnosis. Mammography and an ultrasound (US) scan showed a mass in the upper inner side of the right breast. She then underwent surgery to resect the mass in her right breast. Postoperative pathological examination revealed that the tumor had abundant acinar-like structures formed by tumor cells with prominent eosinophilic granules in the cytoplasm, consistent with acinar cell carcinoma. The results of immunohistochemical analysis supported the diagnosis of breast acinar cell carcinoma. Two months later, she underwent breast-conserving surgery and sentinel lymph node biopsy. The pTNM stage was T2N0M0. After surgery, the patient received 30 radiotherapy sessions. The patient was followed up for a period of one year, and no recurrence was found.

CONCLUSION

AcCC of the breast is a rare type of malignant tumor. Because it is usually asymptomatic and can be detected by imaging studies, routine breast US or mammograms are important. However, there are no characteristic diagnostic imaging findings or clinical manifestations, so immunohistochemical examination is critical for an accurate diagnosis of AcCC of the breast.
Acupuncture for cervical dystonia associated with anxiety and depression: A case report
Authors: Zhang Ya-Ting , Zhang Jin-Jing , Zha Bi-Xiang , Fan Yin-Qiu , Xu Yuan-Bo , Yang Jun , Zhang Qing-Ping
Published: January 2024

BACKGROUND

Cervical dystonia (CD) is a type of muscle tone disorder that usually occurs in the neck muscles. Due to the intermittent or continuous involuntary contraction of the neck muscles, the head and neck are twisted and skewed and some postural abnormalities occur. Long-term abnormal posture or pain can cause negative emotions in patients, which can affect their quality of life.

CASE SUMMARY

This case report included a 37-year-old woman who was diagnosed with CD associated with anxiety and depression; the accompanying symptoms were head and neck tilt of approximately 90° to the right and mental abnormality. After two courses of acupuncture treatment, the patient’s head and neck can be maintained in a normal position, and the negative emotions can be relieved.

CONCLUSION

This case indicates that acupuncture can effectively improve CD and the emotional state and quality of life of patients, making it an effective alternative treatment for the condition.
Chronic venous insufficiency, could it be one of the missing pieces in the puzzle of treating pain?
Authors: Chang Min Cheol
Published: January 2024

Pain is a common complaint among patients seeking medical care. If left untreated, pain can become chronic, significantly affecting patients’ quality of life. An accurate diagnosis of the underlying cause of pain is crucial for effective treatment. Chronic venous insufficiency (CVI) is frequently overlooked by pain physicians. Moreover, many pain physicians lack sufficient knowledge about CVI. CVI is a common condition resulting from malfunctioning or damaged valves in lower limb veins. Symptoms of CVI, ranging from mild to severe, include pain, heaviness, fatigue, itching, swelling, skin color changes, and ulcers in the lower limbs. Recently, it has become more widely known that these symptoms can be attributed to CVI. Even slight or mild CVI can cause related symptoms. Pain physicians primarily consider neuromusculoskeletal disorders when assessing patients with leg pain, and often neglect the possibility of CVI. In clinical practice, when pain physicians encounter patients with unresolved leg pain, they must assess whether the patients exhibit symptoms of CVI and conduct tests to differentiate CVI from other potential causes.
Clinical value of precise rehabilitation nursing in management of cerebral infarction
Authors: Xu Ya-Na , Wang Xiu-Zhen , Zhang Xiao-Rong
Published: January 2024

BACKGROUND

Cerebral infarction, previously referred to as cerebral infarction or ischemic stroke, refers to the localized brain tissue experiencing ischemic necrosis or softening due to disorders in brain blood supply, ischemia, and hypoxia. The precision rehabilitation nursing model for chronic disease management is a continuous, fixed, orderly, and efficient nursing model aimed at standardizing the clinical nursing process, reducing the wastage of medical resources, and improving the quality of medical services.

AIM

To analyze the value of a precise rehabilitation nursing model for chronic disease management in patients with cerebral infarction.

METHODS

Patients (n = 124) admitted to our hospital with cerebral infarction between November 2019 and November 2021 were enrolled as the study subjects. The random number table method was used to divide them into a conventional nursing intervention group (n = 61) and a model nursing intervention group (n = 63). Changes in the nursing index for the two groups were compared after conventional nursing intervention and precise rehabilitation intervention nursing for chronic disease management.

RESULTS

Compared with the conventional intervention group, the model intervention group had a shorter time to clinical symptom relief (P < 0.05), lower Hamilton Anxiety Scale and Hamilton Depression Scale scores, a lower incidence of total complications (P < 0.05), a higher disease knowledge mastery rate, higher safety and quality, and a higher overall nursing satisfaction rate (P < 0.05).

CONCLUSION

The precision rehabilitation nursing model for chronic disease management improves the clinical symptoms of patients with cerebral infarction, reducing the incidence of total complications and improving the clinical outcome of patients, and is worthy of application in clinical practice.
Marker Ki-67 is a potential biomarker for the diagnosis and prognosis of prostate cancer based on two cohorts
Authors: Song Zhen , Zhou Qi , Zhang Jiang-Lei , Ouyang Jun , Zhang Zhi-Yu
Published: January 2024

BACKGROUND

Prostate cancer (PCa) is a widespread malignancy, predominantly affecting elderly males, and current methods for diagnosis and treatment of this disease continue to fall short. The marker Ki-67 (MKI67) has been previously demonstrated to correlate with the proliferation and metastasis of various cancer cells, including those of PCa. Hence, verifying the association between MKI67 and the diagnosis and prognosis of PCa, using bioinformatics databases and clinical data analysis, carries significant clinical implications.

AIM

To explore the diagnostic and prognostic efficacy of antigens identified by MKI67 expression in PCa.

METHODS

For cohort 1, the efficacy of MKI67 diagnosis was evaluated using data from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases. For cohort 2, the diagnostic and prognostic power of MKI67 expression was further validated using data from 271 patients with clinical PCa.

RESULTS

In cohort 1, MKI67 expression was correlated with prostate-specific antigen (PSA), Gleason Score, T stage, and N stage. The receiver operating characteristic (ROC) curve showed a strong diagnostic ability, and the Kaplan-Meier method demonstrated that MKI67 expression was negatively associated with the progression-free interval (PFI). The time-ROC curve displayed a weak prognostic capability for MKI67 expression in PCa. In cohort 2, MKI67 expression was significantly related to the Gleason Score, T stage, and N stage; however, it was negatively associated with the PFI. The time-ROC curve revealed the stronger prognostic capability of MKI67 in patients with PCa. Multivariate COX regression analysis was performed to select risk factors, including PSA level, N stage, and MKI67 expression. A nomogram was established to predict the 3-year PFI.

CONCLUSION

MKI67 expression was positively associated with the Gleason Score, T stage, and N stage and showed a strong diagnostic and prognostic ability in PCa.
Clinical nursing value of predictive nursing in reducing complications of pregnant women undergoing short-term massive blood transfusion during cesarean section
Authors: Cheng Li , Li Li-Ping , Zhang Yuan-Yuan , Deng Fang , Lan Ting-Ting
Published: January 2024

BACKGROUND

Cesarean hemorrhage is one of the serious complications, and short-term massive blood transfusion can easily cause postoperative infection and physical stress response. However, predictive nursing intervention has important clinical significance for it.

AIM

To explore the effect of predictive nursing intervention on the stress response and complications of women undergoing short-term mass blood transfusion during cesarean section (CS).

METHODS

A clinical medical record of 100 pregnant women undergoing rapid mass blood transfusion during sections from June 2019 to June 2021. According to the different nursing methods, patients divided into control group (n = 50) and observation group (n = 50). Among them, the control group implemented routine nursing, and the observation group implemented predictive nursing intervention based on the control group. Moreover, compared the differences in stress response, complications, and pain scores before and after the nursing of pregnant women undergoing rapid mass blood transfusion during CS.

RESULTS

The anxiety and depression scores of pregnant women in the two groups were significantly improved after nursing, and the psychological stress response of the observation group was significantly lower than that of the control group (P < 0.05). The heart rate and mean arterial pressure (MAP) of the observation group during delivery were lower than those of the control group, and the MAP at the end of delivery was lower than that of the control group (P < 0.05). Moreover, different pain scores improved significantly in both groups, with the observation group considerably less than the control group (P < 0.05). After nursing, complications such as skin rash, urinary retention, chills, diarrhea, and anaphylactic shock in the observation group were 18%, which significantly higher than in the control group (4%) (P < 0.05).

CONCLUSION

Predictive nursing intervention can effectively relieve the pain, reduce the incidence of complications, improve mood and stress response, and serve as a reference value for the nursing of women undergoing rapid mass transfusion during CS.
Endoscopic submucosal dissection vs transanal endoscopic surgery for rectal tumors: A systematic review and meta-analysis
Authors: Huang Long-Wu , Zhong Ying
Published: January 2024

BACKGROUND

Endoscopic submucosal dissection (ESD) and transanal endoscopic submucosal dissection (TES) are widely employed surgical techniques. However, the comparative efficacy and safety of both remain inconclusive.

AIM

To comprehensively analyze and discern differences in surgical outcomes between ESD and TES.

METHODS

We conducted a systematic search of the electronic databases PubMed, Embase, Cochrane Central Register of Controlled Trials, Scopus, and CINAHL from inception till August 2023. We analyzed outcomes including recurrence rate, en bloc resection, R0 resection rate, perforation rate, procedure length, and hospital stay length applying a random-effects inverse-variance model. We assessed publication bias by conducting an Egger’s regression test and sensitivity analyses.

RESULTS

We pooled data from 11 studies involving 1013 participants. We found similar recurrence rates, with a pooled odds ratio of 0.545 (95%CI: 0.176-1.687). En bloc resection, R0 resection, and perforation rate values were also similar for both ESD and TES. The pooled analysis for procedure length indicated a mean difference of -4.19 min (95%CI: -22.73 to 14.35), and the hospital stay was on average shorter for ESDs by about 0.789 days (95%CI: -1.671 to 0.093).

CONCLUSION

Both ESD and TES displayed similar efficacy and safety profiles across multiple outcomes. Our findings show that individualized patient and surgeon preferences, alongside specific clinical contexts, can be considered when selecting between these two techniques.
ARTHRITIS GENE THERAPY: FROM CONCEPT TO CLINICAL TRIALS
Authors: Evans C.H.
Published: January 2024

Intra-articular injection is a common way to deliver biologics to joints, but their effectiveness is limited by rapid clearance from the joint space. This barrier can be overcome by genetically modifying cells within the joint such that they produce anti-arthritic gene products endogenously, thereby achieving sustained, therapeutic, intra-articular concentrations of the transgene products without re-dosing. A variety of non-viral and viral vectors have been subjected to preclinical testing to evaluate their suitability for delivering genes to joints. The first transfer of a gene to a human joint used an ex vivo protocol involving retrovirally transduced, autologous, synovial fibroblasts. Recent advances in vector technology allow in vivo delivery using adeno-associated virus (AAV). We have developed an AAV vector encoding the interleukin-1 receptor antagonist (AAV.IL-1Ra) for injection into joints with osteoarthritis (OA). It showed efficacy and safety in equine and rat models of OA, leading to a recently-completed, investigator-initiated, Phase I, dose-escalation clinical trial in 9 subjects with mid-stage OA of the knee (ClinicalTrials.gov Identifier: NCT02790723). Three cohorts of three subjects with mild to moderate OA in the index knee were injected intra-articularly under ultrasound guidance with a low (10e11 viral genomes) medium (10e12 viral genomes) or high (10e13 viral genomes) dose of AAV.IL-1Ra and followed for one year. The data confirm safety, with evidence of sustained intra-articular expression of IL-1Ra and a clinical response in certain subjects. Funding for a subsequent Phase Ib trial involving 50 subjects (ClinicalTrials.gov Identifier: NCT05835895), expected to start later this year, has been acquired. Progress in this area has stimulated commercial activity and there are now at least seven different companies developing gene therapies for OA and a number of clinical trials are in progress.

Acknowledgement: Clinical trial funded by US Department of Defense Clinical Trial Award W81XWH-16-1-0540.
CALCIUM SULFATE/HYDROXYAPATITE-MEDIATED CONTROLLED CO-DELIVERY OF BMP-2 AND ZOLEDRONIC ACID ENHANCES SPINAL FUSION
Authors: Tian X. , Vater C. , Raina D. B. , Findeisen L. , Matuszewski L.-M. , Tägil M. , Lidgren L. , Schaser K.-D. , Disch A.C. , Zwingenberger S.
Published: January 2024

Although bone morphogenetic protein 2 (BMP-2) has been FDA-approved for spinal fusion for decades, its disadvantages of promoting osteoclast-based bone resorption and suboptimal carrier (absorbable collagen sponge) leading to premature release of the protein limit its clinical applications. Our recent study showed an excellent effect on bone regeneration when BMP-2 and zoledronic acid (ZA) were co-delivered based on a calcium sulphate/hydroxyapatite (CaS/HA) scaffold in a rat critical-size femoral defect model. Therefore, the aim of this study was to evaluate whether local application of BMP-2 and ZA released from a CaS/HA scaffold is favorable for spinal fusion. We hypothesized that CaS/HA mediated controlled co-delivery of rhBMP-2 and ZA could show an improved effect in spinal fusion over BMP-2 alone. 120, 8-week-old male Wistar rats (protocol no. 25-5131/474/38) were randomly divided into six groups in this study (CaS/HA, CaS/HA + BMP-2, CaS/HA + systemic ZA, CaS/HA + local ZA, CaS/HA + BMP-2 + systemic ZA, CaS/HA + BMP-2 + local ZA). A posterolateral spinal fusion at L4 to L5 was performed bilaterally by implanting group-dependent scaffolds. At 3 weeks and 6 weeks, 10 animals per group were euthanized for µCT, histological staining, or mechanical testing. µCT and histological results showed that the CaS/HA + BMP-2 + local ZA group significantly promoted bone regeneration than other treated groups. Biomechanical testing showed breaking force in CaS/HA + BMP + local ZA group was significantly higher than other groups at 6 weeks. In conclusion, the CaS/HA-based biomaterial functionalized with bioactive molecules rhBMP-2 and ZA enhanced bone formation and concomitant spinal fusion outcome

Acknowledgements: Many thanks to Ulrike Heide, Anna-Maria Placht (assistance with surgeries) as well as Suzanne Manthey & Annett Wenke (histology).
ADVANCING MUSCULAR DYSTROPHY THERAPY EVALUATION THROUGH MUSCLE-ON-CHIP DEVICES
Authors: Fernández-Costa J.M. , Tejedera-Villafranca A. , Ugarte-Orozco M.J. , Cortés-Reséndiz A. , Ramón-Azcón J.
Published: January 2024

Duchenne muscular dystrophy (DMD) is a prevalent childhood neuromuscular disease characterized by progressive skeletal and cardiac muscle degeneration due to dystrophin protein deficiency. Despite ongoing drug development efforts, no cure exists, with limited success in preclinical studies. To expedite DMD drug development, we introduce an innovative organ-on-a-chip (OOC) platform. This microfluidic device sustains up to six 3D patient-derived skeletal muscle tissues, enabling real-time evaluation of anti-DMD treatments. Our in vitro model recreates myotube integrity loss, a hallmark of DMD, by encapsulating myogenic precursors in a fibrin-composite matrix using a PDMS casting mold. Continuous contractile regimes mimic sarcolemmal instability, monitored through tissue contractibility and Creatine Kinase (CK) levels—an established marker of muscle damage. We further enhance our platform with a nanoplasmonic CK biosensor, enabling rapid, label-free, and real-time sarcolemmal damage assessment. Combining these elements, our work demonstrates the potential of OOCs in accelerating drug development for DMD and similar neuromuscular disorders.