bluuebunny/crossref_metadata_2025 huggingface dataset:
Cushing syndrome from an ACTH-producing pheochromocytoma or paraganglioma: structured review of 94 cases
Authors: Kishlyansky David , Leung Alexander A , Pasieka Janice L , Mahajan Amita , Kline Gregory A
Published: September 2024

Adrenocorticotropic hormone-producing pheochromocytomas/paragangliomas are rare neuroendocrine tumors that co-secrete excess catecholamines and adrenocorticotropic hormone, resulting in Cushing syndrome (CS). This review aims to summarize important patient characteristics, investigations, and outcomes in all cases reported in the English literature. A literature search was conducted to identify all English-language case reports and case series describing adrenocorticotropic hormone-producing pheochromocytomas/paragangliomas. Relevant characteristics were systematically recorded. Cases that did not provide definitive evidence of an adrenocorticotropin (ACTH)-producing pheochromocytoma/paraganglioma were excluded. Our search strategy identified 93 published cases that met the inclusion criteria. We additionally reported one patient for a total of 94 cases. Details related to patient characteristics, laboratory data, and outcomes were commonly underreported. The median age was 47 years, and females accounted for 72% of cases. A cushingoid appearance was reported in 82% of patients, and hypertension in 86%. Infections were reported in 23% of patients. Urinary metanephrines were elevated at least three-fold above normal in 74% of cases. ACTH levels were high in 88% of patients and inappropriately normal in 12%. The median 24-hour urinary cortisol was 21-fold the upper limit of normal. Adrenalectomy was performed in nearly all patients, with 88% achieving a cure for both catecholamine and glucocorticoid excess. A total of 11 patients died. Metastases were uncommon (6%). Adrenocorticotropic hormone-producing pheochromocytomas/paragangliomas are associated with considerable morbidity and mortality. It should be considered in the diagnostic workup of all patients with ectopic CS. Surgical cure is achieved in most patients, and infections are the leading cause of peri-operative mortality.
Pentraxin 3 mediates inflammation and adipogenesis in Graves’ orbitopathy pathogenesis
Authors: Kim Min Seok , Park Hyun Young , Choi Soo Hyun , Chang Eun-Ju , Ko JaeSang , Yoon Jin Sook
Published: September 2024

Pentraxin 3 (PTX3) is a prototypic humoral soluble pattern-recognition molecule known to function in immunity-related inflammation. Given the lack of information on the precise functions of PTX3 in the pathogenesis of Graves’ orbitopathy (GO), this study investigated the role of PTX3 in the inflammation and adipogenesis mechanisms of GO. We first compared the PTX3 expression between orbital tissues from patients with GO and normal controls using real-time PCR, which estimated significantly higher PTX3 transcript levels in the GO tissues than in the normal tissues. In addition, PTX3 production was markedly increased upon interleukin (IL)-1β and adipogenic stimulation. We then evaluated the effects of silencing PTX3 in primary orbital fibroblast cultures by analyzing the expression levels of pro-inflammatory cytokines, adipogenesis-related proteins, and downstream transcription factors in cells transfected with or without small interfering RNA against PTX3, using western blot. Silencing PTX3 attenuated the IL-1β-induced secretion of pro-inflammatory cytokines, including IL-6, IL-8, monocyte chemotactic protein-1, intercellular adhesion molecule-1, and cyclooxygenase-2, and suppressed the IL-1β-mediated activation of p38 kinase, nuclear factor-κB, and extracellular signal-regulated kinase. Moreover, PTX3 knockdown suppressed adipogenic differentiation, as assessed using Oil Red O staining, as well as the expression of adipogenesis-associated transcription factors including peroxisome proliferator-activated receptor-γ, CCAAT/enhancer-binding proteins α and β, adipocyte protein 2, adiponectin, and leptin. Thus, this study suggests that PTX3 plays a significant role in the pathogenesis of GO and may serve as a novel therapeutic target for the condition.
The Success of Treatment for Osteoarthritis with a Genicular Nerve Block is Associated with Patients’ Body Mass Index
Authors: Joseph Pitts  , Madeline Henry  , Anish Sethi  , Huaqing Zhao
Published: September 2024

Background: While the mainstay of treatment for severe osteoarthritis of the knee has been total knee arthroplasty, a prognostic genicular nerve block (GNB) followed by cooled radiofrequency ablation (CRFA) has been shown to provide long term relief of osteoarthritic knee pain and its disability. The goal of this study is to determine if there is a difference in the demographic makeup of those who had a successful prognostic genicular nerve block compared to those who did not.
Methods: A retrospective chart review of 224 genicular nerve blocks was completed. The nerve block was considered successful if the patient reported a 50% or greater pain reduction for a week or more at follow up. Demographic cohorts that were compared include sex, age, race, and BMI.
Results: Those who were categorized as non-obese, 36 out of 69 (52.2%) had unsuccessful blocks while 33 out of 69 (47.8%) in this BMI category had successful blocks. Of those who were categorized as obese, 25 out of 75 (33.3%) had unsuccessful blocks while 50 out of 75 (66.7%) in this BMI category had successful blocks. Of those who were deemed morbidly obese, 22 out of 75 (29.3%) had unsuccessful blocks while 53 out of 75 (70.7%) in this BMI category had successful blocks. These results were found to be statistically significant with a p-value of .011. Furthermore, GNB success was not found to be significantly impacted by patient age, race, or gender.
Conclusions: These findings demonstrate the utility of prognostic genicular nerve blocks in all patients with osteoarthritis of the knee, but, in particular, the obese patient, who experiences a greater chance of pain relief on average.
The Issue of Violence against Transgender People in Prisons
Authors: Petrėnaitė Daiva
Published: September 2024

This article analyses the issue of violence against transgender individuals in prisons, focusing on legislative regulation in various countries. According to the study, transgender people are more likely to commit crimes as a result of systemic discrimination, but they are also more likely to face violent attacks once inside prison. It could be argued that international legal instruments aimed at ensuring transgender rights in prisons are not effective, and they regulate the rights of prisoners in a more general manner. Positive examples of legal regulation regarding the protection of transgender rights in various countries can also be viewed as best practices. This study suggests that legal reforms are required in transgender inmate rights policies to prevent incidents of violence.
SHAKESPEARE’S IMAGE IN LITERARY AND THEATRICAL CRITICISM BY P. P. GNEDICH
Authors: Zhatkin Dmitry , Serdechnaia Vera
Published: September 2024

The authors analyze Shakespearean criticism and translation principles of Pyotr Petrovich Gnedich (1855–1925), prose writer, playwright, art critic, and famous theater figure of the turn of the 20th century. The purpose of the work is to clarify Gnedich’s place in Russian Shakespearean literature and to elucidate the vision of Shakespeare in his criticism. The objectives of the work include an overview of Gnedich’s translation and production contribution to the history of Russian theatrical Shakespeare; a study of Gnedich’s criticism of Shakespearean drama on the Russian stage; consideration of Gnedich’s translation principles as the precursors of the accurate translation school. Results of the work: Gnedich writes about Shakespeare, translates his plays and stages them over the course of his life; he does not deviate from the idea that Shakespearean drama is advanced and challenges the theater, first and foremost, the Russian theater. Gnedich measures the development of theatre according to Shakespeare and notes the sad neglect of his plays in the history of Russian theater: despite all of his efforts, from the dominance of everyday plays, the Russian theater shifts towards a predominance of new drama and symbolism. Gnedich’s translations are also inspired by the idea of updated, more accurate Shakespeare on the Russian stage. Thus, in his appeal to Shakespeare, Gnedich pursues new principles without yet naming them: in production work — he leans towards director’s theater, in translation — towards accurate translation (which will later be called “equirhythmic”.) Gnedich was the first to introduce “Julius Caesar” to the Russian stage in 1897 and the first to stage Shakespeare on a chamber stage (at the St. Petersburg Maly Theater of A. S. Suvorin). In 1922, Gnedich offers an unusual concept of the image of Hamlet as a typically Russian passive character, regarding the play as a kind of warning against the position of an inactive “superfluous man.”
Formation of an Intellectual and Innovative Environment of the Insurance System Development in Ukraine and Worldwide
Authors: VOYTOVYCH L. , VOYTOVYCH D.
Published: September 2024

Introduction. The article highlights the main innovative trends in the development of the insurance system of Ukraine and analyses innovative insurance technologies with the possibility of their implementation in the domestic insurance practice. The insurance system is the largest investor in Europe, so investments are a key component of the insurance business model. The priority of the modern insurance system is the use of digital platforms, artificial intelligence, the Internet, and blockchain technologies.Problem Statement. A key prerequisite for the development of society in today’s economic environment is innovation. The proliferation of digital electronic technologies, the emergence and widespread testing of universal multifunctional mobile phones, and the increasing reliance on Internet resources have all become pivotal factors in transforming the fundamentals of economic relations. Consequently, business processes are becoming more streamlined, innovative product channels and services are being developed, and customer service technologies are advancing.Purpose. The purpose of the research is to study global trends in the development of innovative insurance technologies and the possibilities of their application in the insurance system of Ukraine.Materials and Methods. The general scientific and special methods of analysis and synthesis, comparison, systematization, statistical and graphical methods, tabular method have been employed.Results. In Ukraine, notable examples of co-branding with banks include alliances such as Piraeus Bank with IC UNIQA and IC Alfa Insurance; Unex Bank with IC VUSO; and OTP Bank with IC Arsenal Insurance. This article highlights the main global achievements of insurance systems in the Insurtech field. The most promising ways to enhance insurance services are through artificial intelligence, machine learning, and big data analysis. Each year, the domestic insurance system is enriched with innovative products, including sales automation, home security, mobile security, extreme security, and the CyberEdge cyber risk insurance program, among others.
Conclusions. The priority areas for the development of innovative technologies in the domestic insurance system include the utilization of advanced sales channels for insurance products based on telematics and artificial intelligence, the implementation of blockchain technology, and the introduction of microinsurance. These advancements aim to enhance risk protection and tosimplify customer access to the services off ered by insurance companies.
Adaptation of Islamic Finance to the Performance of MSMEs in the Halal Food Industry
Authors: Gunarto Muji , Yanti Pitri
Published: September 2024

Research Originality: The findings of this research will contribute to the Islamic finance literature by answering the research gap between the relationship between MSME adaptation of Islamic finance implementation and MSME performance and providing practitionerinsight for policymakers and MSMEs in the halal food industry.Research Objectives: This study aims to determine the adaptation of Islamic finance to the performance of MSMEs in the halal food industry. Research Methods: The method used a quantitative and explanatory approach. The number of samples in this study was 212 MSME units taken by simple random sampling (SRS). The number of samples in this study is based on the needs of the analytical tools used. The analysis technique used is the structural equation model (SEM) approach with the help of the LISREL program.Empirical Results: The main findings show that halal industry MSMEs that adapt to Sharia finance tend to have a higher level of innovation than those that do not. Data shows that financing by Sharia principles enables MSMEs to allocate their resources more effectively, strengthening their ability to innovate in products and services. Innovations carried out by halal industry MSMEs that adopt a Sharia financial approach are more consistent with Sharia values, which leads to increased acceptance by Muslim consumers.Implications: MSME halal industry managers may consider adopting Islamic finance strategies as part of their business plans. This adoption includes using Sharia financing, investing according to Sharia principles, and managing their finances according to Sharia values. Managers also need to actively develop networks and collaborate with other stakeholders, including Sharia financial institutions, educational institutions, and other companies in the halal industry ecosystem.JEL Classification: D14, G21, L25How to Cite:Gunarto, M., & Yanti, P. (2024). Adaptation of Islamic Finance to the Performance of MSMEs in the Halal Food Industry. Etikonomi, 23(2), 369 – xx. https://doi.org/10.15408/etk.v23i2.34271.
Microbiology of boreal acid sulfate soils: Biogeochemical drivers of acidity generation and metals leaching
Authors:   , Johnson Anders
Published: September 2024

Acid sulfate soils are described as the nastiest soils on Earth and are broadly composed of metal sulfides. These minerals are mostly harmless in a reducing environment. However, when these soils are drained oxygen infiltration occurs. Oxidation initiates a geochemical process, thereby starting the generation of acidity. As the pH drops, a consortium of acidophilic microbiota begin to grow and flourish. These microbes catalyze the oxidation reactions, which further generates acidity, thus driving the pH even lower. The decreasing pH leads to the solubilization of any co-occurring metals within the system. During flushing events the built-up acidity and solubilized metals mobilize and flow out of the soils into surrounding waterways to the potentially lethal detriment of resident flora and fauna. This dissertation firstly explores the microbial communities that inhabit acid sulfate soils throughout Sweden and around Vaasa, Finland, and secondly the analogous communities of a mine waste rock repository in northern Sweden. Results from Finland showed an increase in relative abundances of extremely acidophilic microbes correlated to the decreasing pH values that followed the oxidation front. Acidity generation was not mitigated by additions of lime. Further laboratory incubations found that higher volumes and finer material sizes of lime delayed acid generation but did not prevent the development of neutrophilic iron and sulfur oxidizing microbes. The survey of Sweden extended the distribution range of acid sulfate soils and found community differences between the northerly and southerly acid sulfate soils, which were hypothesized to be a result of regional temperature variation. Furthermore, regional differences of the field oxidized samples disappeared following laboratory incubations, further supporting temperature as a driver of regional differences. Lastly, the Swedish waste rock repository study suggested that there were tipping points associated with ongoing oxidation. Subsurface associated communities rapidly decreased following excavation and were slowly replaced by a simple acidophilic community; over time a radiation of acidophiles occurred leading to an increase in acidophile diversity. These studies together show that metal sulfide rich environments are host to resident neutrophilic to extreme acidophilic microbial communities that play integral roles to the generation of acidity and metals leaching. The composition of those communities differ based on temperature, pH, substrate type, and oxidation age. With regard to remediation strategy development, the application of fine grained lime in combination with peat may hold potential to for short termed acidity mitigation. However caution is required when transitioning from laboratory based approaches to field trials as the communities are dynamic and complex.
Zastosowanie obligacji zamiennych do obniżania kosztu kapitału w przedsiębiorstwie na podstawie analizy wybranych instrumentów notowanych na rynku Catalyst
Authors: Rybka Anna
Published: September 2024

A developing company can obtain capital from two main sources: issuing shares and debt. Both methods have their advantages but also some risk factors. Issuing convertible bonds, a form of hybrid financing, is one way to address the risk. These financial instruments enable a company to decrease its cost of capital while also allowing investors to profit from a conversion premium.  Analysis of convertible bonds traded on the Catalyst market shows that the hybrid instruments are the most efficient when the market price of the company is low and issuing shares might not bring about the desired results. Moreover, additional rights incorporated into convertible bonds enable the company to decrease the coupon rate and costs of issuing debt.
Stabilizacja kursów walutowych w obliczu kryzysu finansowego - próba oceny
Authors: Pera Jacek
Published: September 2024

The recent volatility of exchange rates of practically all currencies exerts a direct influence on import/export prices, interest rate levels, state budget revenues and profits. This has had a destabilising effect on national economies and consequently triggered a financial crisis, i.e. the situation that we are currently in. One important factor is the apparent dependence of financial markets on the monetary and exchange rate policies pursued by the financial institutions of key-currency countries. These institutions, accordingly, have a great deal of responsibility for stabilising key financial markets and collaboration between the main institutions of the Triad, i.e. the US Federal Reserve, the Bank of Japan and the European Central Bank. In the absence of coherent, unified and widespread stabilisation mechanisms at the level of national economies and in the face of speculative behaviour by private and institutional investors, plus speculative strategies being commonly adopted by businesses, international financial markets remain highly turbulent and companies have to cope with a rising expense bill.
Ewolucja controllingu w Polsce i na świecie
Authors: Nesterak Janusz
Published: September 2024

Aware that business processes are complicated, company managers strive to find solutions that will enable them to make decisions that restrict business risk. The many years of experience foreign companies bring as well as, more and more often, that of domestic companies show that controlling can be one such instrument. In spite of the increasing importance of controlling in the economic sciences and in business practice, there are still discrepancies in the understanding of this notion. Thus, there is no uniform definition for controlling to be found in the world literature, and numerous leading managers have struggled to define it. The article presents the origin and stages of development of controlling in the world. The author also presents his own approach to defining it.
Badanie występowania transakcji z wykorzystaniem informacji poufnych na Giełdzie Papierów Wartościowych w Warszawie
Authors: Niedużak Marcin Stanisław
Published: September 2024

The article serves as an introduction to one phenomenon occurring on world financial markets - the use of confidential information and its influence on financial tools, commonly referred to as insider trading. Using the GARCH model, the article presents an empirical verification of market abuse occurring in real time. Alerts concerning the possible existence of market abuse were selected on the basis of the estimated variability of returns of three companies listed on the Warsaw Stock Exchange. However, the results of this analysis do not prove the existence of insider trading on the Warsaw Stock Exchange, but do hint at its existence, which would have to be investigated by the authorities.
A controvérsia sobre o salário-mínimo e a taxa de salários na economia brasileira: novas evidências
Authors: SABÓIA JOÃO L. M.
Published: September 2024

RESUMO Alguns artigos surgiram recentemente na literatura econômica brasileira discutindo o papel desempenhado pelo salário mínimo na determinação da taxa salarial no setor formal da economia. Este artigo tenta lançar alguma luz sobre a discussão através da utilização de novas evidências empíricas. Acabamos concluindo que o salário mínimo é muito importante para determinar a taxa salarial no Brasil.
A moeda indexada: nem mágica nem panaceia
Authors: RESENDE ANDRÉ LARA
Published: September 2024

RESUMO O autor formulou uma proposta baseada em uma nova moeda indexada com o objetivo de superar o impasse em que se encontra a política econômica de combate à inflação. Esta peça é ao mesmo tempo uma resposta às críticas e uma oportunidade para comentar sugestões.
Estado da arte da produção acadêmica sobre ensino de Evolução Biológica no Brasil (1991-2021): um estudo baseado em dissertações e teses
Authors: Santos William Rossani dos , Fernandes Rebeca Chiacchio Azevedo
Published: September 2024

Resumo: Esta pesquisa, caracterizada como Estado da Arte, teve o objetivo de mapear e descrever a produção acadêmica sobre o ensino de evolução biológica desenvolvida no Brasil no período de 1991 a 2021. Por meio da Biblioteca Digital Brasileira de Teses e Dissertações (BDTD), do Banco de Teses e Dissertações da CAPES e do Centro de Documentação em Ensino de Ciências (CEDOC) da Unicamp, foram identificados 266 trabalhos, constituídos por 213 dissertações de mestrado e 53 teses de doutorado. Estes estudos foram examinados de acordo com os descritores: ano de defesa, titulação acadêmica, distribuição geográfica, instituições de origem, programas de pós-graduação, autoria, orientação, níveis educacionais e modalidades de ensino, e focos temáticos. Os resultados apresentam as características da base institucional e as principais tendências que sustentam a produção acadêmica neste tema, visando propiciar o panorama das três décadas no qual as dissertações e teses vêm se desenvolvendo no contexto nacional.
OCORRÊNCIA E CONTROLE DA FERRUGEM EM CHERIMÓLIA NO ESTADO DE SÃO PAULO
Authors: Ferrari J.T. , Nogueira E.M. de C. , Hennen J.F. , Figueiredo M.B. , Coutinho L.N. , Louzeiro I.M.
Published: September 2024

RESUMO Amostras de folhas e frutos de cherimólia, provenientes de Pedra Bela, SP, com sintomas de ferrugem, foram recebidas para análise pelo CPDSV no ano de 2002. Observações microscópicas mostraram a forma uredinial (II), que devido às características dos urediniosoros, indicava tratarse da espécie Phakopsora neocherimoliae Buriticá & Hennen. Visando um controle químico da doença, instalou-se um experimento de campo com seis tratamentos, quatro repetições/parcela e 3 aplicações a intervalos de sete dias. Os produtos e doses de ingrediente ativo/100 L de água foram: mancozeb 80% - 20 g; oxicloreto de cobre 50% - 25 g; tebuconazole 20% - 5 mL; difenoconazole 25% - 20 mL; tiofanato metílico 50% - 10 mL. A avaliação foi feita com base na severidade da doença, atribuindo-se notas de 0 a 5. Pela análise de variância e das médias comparadas pelo teste de Tukey a 5%, todos os fungicidas mostraram eficiência no controle da doença. Essa é a primeira constatação de ferrugem em cherimólia, causada por Phakopsora neocherimoliae no Brasil.
PERCEPÇÕES SOBRE DEMOCRACIA, DESIGUALDADES E POLÍTICAS PÚBLICAS DE COMBATE À FOME E À POBREZA NO BRASIL
Authors: Justo Carolina Raquel Duarte de Mello , Del Porto Fabíola Brigante
Published: September 2024

O que as políticas sociais, de combate à fome, à pobreza e às desigualdades dizem sobre a democracia brasileira? E qual o apoio que recebem dos brasileiros? Temos no Brasil as bases de legitimidade para a implementação de políticas mais igualitárias e redistributivas, nos moldes socialdemocratas de Welfare-State? Interessa conhecer as percepções de diferentes grupos sociais sobre as desigualdades e meios de combatê-las, já que as políticas públicas são importante ponto de contato entre Estado, governo e cidadãos, através das quais informam e se informam sobre demandas, preferências e interesses políticos. Uma vez que as opiniões expressas afetam e são afetadas pelas ações do Estado, interferem na dimensão social e substantiva da igualdade da democracia. No Brasil, percepções sobre pobreza, desigualdades, assistência social, transferência de renda, o Programa Bolsa Família, suas origens e suas justificativas variam. Conhecê-las ajuda a entender para aperfeiçoar a democracia brasileira. Para isso, o trabalho faz revisão bibliográfica da relação entre democracia, direitos de cidadania e políticas públicas, a partir da percepção dos cidadãos, divididos em estratos sociodemográficos, sobre pobreza, fome, desigualdades e ações do Estado e critérios de justiça para combatê-las. São usados estudos comparativos, qualitativos e quantitativos, incluindo grupos como elites, burocratas do nível da rua e altos escalões, beneficiários de políticas, etc. Por fim, é realizada análise exploratória e longitudinal dos dados dos surveys Latinobarômetro e LAPOP, que confirmam a diversidade e ambiguidade de percepções apontada pela literatura.
NÖTROSOFİK AHP, WASPAS ve ABC YÖNTEMLERİ İLE STOK YÖNETİMİNİ OPTİMİZE ETME: YEDEK PARÇA SATIŞ FİRMASI ÖRNEĞİ
Authors: Güler Beyza , Nebati Emine Elif
Published: September 2024

Stok yönetimi, bir işletmenin tedarik zinciri içindeki envanter akışını etkin bir şekilde kontrol etme, planlama ve iyileştirme süreçlerini kapsar. Günümüz dinamik iş dünyasında, firmaların etkin stok yönetimi, rekabet avantajı elde etmeleri açısından büyük bir öneme sahiptir. Doğru stratejilerin geliştirilmesi, maliyetleri minimize etmek ve müşteri taleplerine hızlı bir şekilde yanıt vermek stok yönetiminin en önemli konu başlıklarındandır. Bu çalışmada, ABC analizi, nötrosofik AHP ve WASPAS yöntemlerini kullanarak bir yedek parça satış firmasının stok yönetimi süreçleri karşılaştırmalı olarak analiz edilmiş ve iyileştirmeye yönelik öneriler sunulmuştur. Çalışmanın ilk aşamasında, ABC analizi yöntemi kullanılmış, belirlenen parçalara yıllık maliyet ve kullanım adetlerine göre sınıflandırma işlemi uygulanmıştır. Nötrosofik AHP yöntemi, stok yönetiminde kullanılan kriterlerin ağırlıklarını belirlemek için kullanılmıştır. Bu adım, önemli performans kriterlerini belirlemek ve bu kriterlerin firma hedefleri ile uyumunu değerlendirmek için kullanılmıştır. Sonrasında WASPAS yöntemi ile belirlenen parça modellleri, her bir kriter açısından değerlendirilerek sıralamalar elde edilmiştir. Elde edilen bulgular, entegre modelin stok yönetiminde daha etkili ve ölçülebilir bir yaklaşım sağladığını ortaya koymuştur. Bildiğimiz kadarıyla, önerilen metodolojinin, alanda ilk kez kullanılması ile yazına katkı sağlayacağı umulmaktadır.
A PATH TOWARDS SUSTAINABLE DEVELOPMENT FROM FISCAL INSTRUMENTS: THE ROLE OF TAX REVENUES AND PUBLIC EXPENDITURES
Authors: Değirmenci Tunahan
Published: September 2024

Tax and expenditure policies have a range of economic, social, and environmental objectives. Although these policies are multidimensional, the relevant literature focuses on a single dimension. The long-run aim of public policies, including tax and expenditure policies, is to ensure sustainable development that includes all these dimensions. The sustainable development index is a broad indicator that combines economic, social, and environmental factors, including human development and ecological quality. This study aims to examine the effect of tax revenues and public expenditures on the sustainable development index in Turkiye for the period 1990-2019. According to the study results, while tax revenues affect sustainable development positively, public expenditures affect it negatively. The results of the study support that Turkiye implements its tax policy in a balanced manner towards sustainable development goals and emphasizes that it should review its expenditure policy. This study underscores the importance of aligning both tax and expenditure policies to effectively pursue sustainable development objectives in Turkiye.
KARBON EMİSYONLARININ KONTROL ALTINA ALINMASINDA ÇEVRE VERGİLERİ VE YENİLENEBİLİR ENERJİNİN ETKİNLİĞİ: AB EKONOMİSİNDEN KANITLAR
Authors: Çobanoğulları Gökhan , Karakoç Çağrı
Published: September 2024

Günümüzde karbon emisyonları küresel bir sorun olarak ülkeler için büyük bir problem teşkil etmektedir. Bu sorunu kontrol altına almak için ülkeler, çevre vergilerini bir araç olarak kullanmaktadır. Ayrıca, üretim düzeyinde yenilenebilir enerji kaynaklarının kullanımı ile de karbon emisyonlarını azaltma çabası içindedirler. Buradan hareketle bu çalışmada, karbon emisyonları üzerinde çevre vergileri ve yenilenebilir enerji tüketiminin etkisi 29 AB üyesi ülke için 1995-2020 dönemi verileri sistem GMM yöntemi kullanılarak incelenmiştir. Dinamik panel analizi yöntemiyle gerçekleştirilen bu incelemede, karbon emisyonunun yıllara göre seyri, çevre vergileri ve yenilenebilir enerji tüketimi değişkenleri ile açıklanmaya çalışılmıştır. Bulgular, CO2 emisyonu ile çevre vergi gelirleri arasındaki ilişkinin anlamlı ve pozitif olduğunu göstermektedir. Çevre vergi gelirlerindeki %1’lik bir artışın CO2 emisyonlarını %0.077 oranında azalttığı belirlenmiştir. Ayrıca, yenilenebilir enerji tüketiminin artırılmasının da karbon emisyonlarını azalttığı tespit edilmiştir. Bu bulgular, sürdürülebilir bir çevre için devlet politikalarının çevre vergileri ve yenilenebilir enerji tüketimi odaklı olması gerektiğini göstermektedir
Técnicas de neutralización y participación en actividades de tráfico de drogas en Sonora México
Authors: Piña-Osuna Francisco-Manuel
Published: September 2024

Introducción: el estudio describe la manera en que un grupo de personas justificaron actividades de tráfico de drogas en la frontera norte de México, partiendo de la teoría de la neutralización. Objetivo: el objetivo del estudio es describir la manera en que un grupo de personas justificaron sus actividades relacionadas con el tráfico de drogas en la frontera norte de México. Metodología: usando metodología cualitativa, mediante entrevista semiestructurada a 9 hombres y 2 mujeres privados de la libertad por tráfico de drogas en Sonora, México, se exploraron las diversas técnicas de neutralización que consideraron en su proceso de ingreso a dichas actividades. Conclusiones: los resultados muestran que la negación de la responsabilidad y desacreditar los órganos de justicia, son justificaciones de mayor uso. Se concluye que la neutralización aporta al entendimiento del control social, la incidencia y reincidencia delictiva.
Interacciones narco-culturales en comunidades indígenas del Chaco Paraguayo: reconfiguraciones históricas e implicancias sociales
Authors: Peris Carlos-Anibal , Moriconi Marcelo
Published: September 2024

Introducción: aunque el narcotráfico ha sido una práctica histórica en el Chaco Paraguayo, las dinámicas sociales cambiaron en los últimos años, generando un orden social híbrido en el que los rectores del narco habrían ganado poder, los grupos indígenas habrían quedado desprotegidos y a merced de los traficantes, y la política se habría desentendido de la comunidad y liberaría zonas para facilitar y proteger el negocio ilegal. Objetivo: ante este contexto, el artículo describe las percepciones sociales sobre el narco y la política en comunidades indígenas del Departamento de Alto Paraguay. Metodología: la investigación se basa en un enfoque cualitativo multi-método que incluye documentación, etnografía y entrevistas a informantes clave. Conclusiones: el trabajo demuestra cómo la deslegitimación de la política formal y de la legalidad crean áreas de riesgo no sólo para la expansión y tolerancia social de la criminalidad, sino también para la legitimación de la ilegalidad como medio para conseguir una vida (más) digna. En este sentido, el artículo cuestiona que la literatura sobre gobernanza criminal y narcopolítica se ha centrado más en los adjetivos que en los sustantivos. La ineficiencia previa de la gobernanza y la política es la que crea las condiciones para la emergencia de los adjetivos indeseados (como criminal o narco). El desafío no es tanto combatir el crimen como promover una gobernanza y una política revalorizada.
Narcotráfico y política en territorio indígena. Resistencia entre los Tsotziles y Tseltales de Chiapas – México
Authors: Varón-Rojas Diego-Hernán , Delgado-López José-Enrique
Published: September 2024

Introducción: diversos grupos humanos han sido atrapados por las redes de la narcopolítica. Muchas comunidades étnicas, producto de la marginación y la discriminación sistemática desde tiempos coloniales hasta la actualidad, han sido cooptadas por los narcos para su beneficio. Objetivo: analizar el papel que han jugado las comunidades indígenas frente a las interdependencias entre narcos y políticos, en territorios de los Tsotsiles y los Tseltales de los Altos de Chiapas, México.  Metodología: se realizó una investigación exploratoria de tipo cualitativo, que incluyó las técnicas de observación participante, entrevistas desestructuradas con habitantes de la zona y revisión de fuentes secundarias. El análisis considera elementos del discurso, presentados siguiendo una secuencia histórica. El estudio se apoyó en la teoría de dependencia de recursos, que reconoce diferentes estrategias para su resistencia. Conclusiones: las comunidades estudiadas han logrado permanecer distantes al poder de los narcos. Por un lado, mediante la estrategia de traslado sigiloso hacia municipios adyacentes a donde han empezado tener presencia los carteles. Y segundo, la cohesión social se logró debido a un fuerte sistema de cargos políticos, que impide a integrantes de organizaciones que compiten por recursos escasos, alcanzar altos niveles de la jerarquía administrativa de las comunidades.
The relationship between tumor budding and survival of patients with breast cancer: A meta-analysis
Authors: Xu Hongjie , Wei Dajun
Published: September 2024

Tumor budding has been proposed as a potential prognostic marker in various cancers, but its association with survival outcomes in breast cancer (BC) remains unclear. This meta-analysis aimed to clarify the relationship between tumor budding and survival outcomes in patients with BC. A comprehensive literature search was conducted in PubMed, EMBASE, and Web of Science. Cohort studies examining the association between tumor budding and overall survival (OS) and progression-free survival (PFS) in BC patients were included. Hazard ratios (HRs) and 95% confidence intervals (CIs) were pooled using a random-effects model to account for potential heterogeneity. Eleven cohort studies, including 2,828 patients, met the inclusion criteria. High tumor budding was significantly associated with poorer OS (HR = 1.89, 95% CI = 1.37–2.60, P < 0.001) and PFS (HR = 1.89, 95% CI = 1.32–2.71, P < 0.001). Subgroup analyses revealed a stronger association in studies where high tumor budding was defined as ≥ 10 buds / high-power field (HPF) compared to those with lower cutoffs. Sensitivity analyses confirmed the robustness of the findings. This meta-analysis demonstrates that high tumor budding is associated with significantly worse OS and PFS in BC patients, underscoring its prognostic significance. These findings suggest tumor budding could be a valuable marker in clinical assessments, and further research is needed to standardize its evaluation criteria in BC.
Algebraic Cubic Equation vs. Freedman Equations for the Geometry of our Universe
Authors: S Kalimuthu
Published: September 2024

In 1921 the famous Russian mathematician Alexander Freedman proved by analyzing Einstein’s general relativity that the geometry of our Universe has three possibilities namely Euclidean, Hyperbolic, and Spherical. Various cosmological experimental and observational probes of BOOMERanG, NASA’s WMAP, and ESA’s PLANCK mission revealed that the shape of our universe is flat. But to this day, there is no mathematical formulation for the geometry of our universe. In this short work, the author attempts to show that the geometry of our universe is Euclidean.
Quantitative targeted metabolomics for ASO mouse model using Biocrates Q500 Platform v2
Authors: MahmoudianDehkordi Siamak
Published: September 2024

Using the biocrates MxP‱ Quant 500 kit (biocrates life science AG, Innsbruck, Austria), a commercially available targeted metabolomics kit, we assessed 630 metabolites across 26 biochemical classes in different tissues of ASO and wild-type mice. All samples were processed through the metabolomics phenotyping services platform of Biocrates Life Sciences.
Micro Volume Purification of His-Tagged Proteins with IMAC Ni-Charged Resin v1
Authors: Schlecht Syon , Gunderson Emily , Fowler Ruthie , Aguilar Takara
Published: September 2024

This protocol describes a micro volume purification method for His-tagged proteins using IMAC with Ni-charged resin in a mini spin chromatography column. His-tagged proteins are selective bound to a Ni-charged resin due to the interaction between the polyhistidine tag and Ni²⁺ ions and eluted using imidazole-containing buffers. Desalting is the performed using SEC where salts and imidazole are fractionated, while larger molecules like the target protein are excluded. This results in the isolation of purified His-tagged proteins with a high yield and minimal contaminants, suitable for downstream applications.
Para una cartografía de los temas y las preocupaciones de la bibliotecología argentina en las décadas de la profesionalización (1940-1950)
Authors:   Universidad Nacional de La Plata, Planas Javier
Published: September 2024

En este estudio se propone un relevamiento de los temas que fueron agenda de la bibliotecología argentina durante las décadas de la profesionalización (1940-1950). Se tomó como documento de análisis la Bibliografía bibliotecológica argentina, de Nicolás Matijevic (1969), que recopila información publicada entre el siglo XIX y 1967. En primer lugar, se comparó la producción bibliográfica del período de profesionalización con la etapa anterior y la inmediatamente posterior. En segundo lugar, se revisaron y ponderaron los principales temas trabajados por los bibliotecarios. Finalmente, se describen las características elementales de la literatura bibliotecológica durante los años de la profesionalización. Entre otras conclusiones, se destaca la aparición de nuevas temáticas entre las preocupaciones principales de los bibliotecarios, como su propia formación y la bibliotecología y la documentación como disciplinas.
Features of the microbiota for various malignant neoplasms
Authors: Solenova L. G. , Ryzhova N. I. , Antonova I. A. , Belitsky G. A. , Kirsanov K. I. , Yakubovskaya M. G.
Published: September 2024

The development of omics technologies and sequencing has significantly expanded the understanding of the role of microorganisms that inhabit various human organs and collectively make up its microbiota in the development of cancer. The extensive literature of recent years devoted to various aspects of the participation of the microbiota in carcinogenesis substantiates the relevance of analyzing the impact of its features on the processes of carcinogenesis in various human organs.

   Purpose of the study. Analysis of literature data on the key issues of the relationship between the human microbiome and the risk of cancer and explore possible prospects for its use in the diagnosis, therapy and prevention of cancer.

   Materials and methods. A literature search was carried out in the databases NCBI MedLine (PubMed), Scopus, Web of Science, based on an extended list of keywords that included all the localizations of malignant neoplasms (MNs) considered in the review. Original studies, meta-analyses, randomized controlled trials, and reviews published in recent years were used.

   Results. Recent studies using omics technologies have shown significant differences in the composition of microbial communities of healthy and tumor tissues and have made it possible to characterize the potential tumor microbiota in some types of cancer. The microbiota present in the various organs of the human body forms a network through which it interacts via migration or by forming metabolic axes between organs. Dysbiosis plays an important role in carcinogenesis, and its presence in one organ can negatively affect the condition of other distant organs and contribute to the development of pathological conditions in them.

   Conclusion. Numerous studies conducted over the past decade have revealed a complex relationship between microorganisms, tumors, and the host, reflecting the diverse effects of the microbiota on various organ- specific types of MNs. Gastrointestinal tract tumors, as well as sites outside it with significant bacterial associations, have been identified for a better understanding of the multifaceted mechanisms by which the microbiota influences cancer. The data obtained so far complement the emerging possibilities of using the microbiota in clinical practice, which represents a new approach to the prevention and treatment of malignant neoplasms.
Error Analysis in ChatGPT’s MARC21 Records: A Study of RDA Conformity
Authors: Niveditha B. , Harinarayana N. S. , Balachandran Chikku
Published: September 2024

This study aims to evaluate the accuracy and quality of MARC21 catalogue records generated by ChatGPT using bibliographic data from title pages. The study will shed light on the effectiveness and reliability of automated cataloguing processes utilising AI technology. This involves examining factors such as correctness, consistency, and adherence to Resource Description and Access (RDA) standards. The analysis highlights variations in error rates across different records. Identifying the underlying causes of errors in records with higher rates can help in implementing targeted improvements to enhance the data quality and consistency of ChatGPT-generated catalogue records.
Relationship of conflict resolution culture and personal characteristics of future doctors
Authors: Shcherbakova O. I. , Serdakova K. G. , Sorin A. V. , Kiseleva M. G. , Krylova N. A. , Komissarenko A. O.
Published: September 2024

Introduction. The article is devoted to the study of the relationship between conflict resolution culture and the personal characteristics of future doctors. Aim. The present research aimed to examine the relationship between the conflict resolution culture of medical university graduates and the key personality traits that influence a doctor’s professional activities: trust and aggressiveness. Methodology and research methods. The testing method employed various psychological tools, including O. I. Shcherbakova’s methodology for assessing the level of conflict resolution culture in individuals, J. B. Rotter’s Interpersonal Trust Scale, and the Bass-Darkey test, a standardised questionnaire designed to measure aggressive and hostile reactions developed by A. Bass and A. Darkey. Descriptive statistics, correlation analysis, regression analysis, and factor analysis were utilised to process the data. The study sample consisted of 300 graduates from the medical faculty of Sechenov University, aged between 22 and 28 years. Results. Graduates exhibit an average level of conflict resolution culture (46.6), an average level of interpersonal trust (78.6), and elevated indices of hostility (52.73) and aggressiveness (53.09), along with a high level of resentment (59.58). Correlation analysis of the study data identified 14 statistically significant relationships between the components of conflict resolution culture and various forms of aggression; however, no statistically significant relationships were found with the level of interpersonal trust. The multiple regression model developed by the authors indicated that 22.8% of the high level of conflict resolution culture can be attributed to the low levels of physical aggression and suspicion. Practical significance. A significant contribution of this study is the identification of the relationship between conflict resolution culture and the personal characteristics of medical university graduates, such as trust and aggressiveness. This research lays the groundwork for developing programmes aimed at enhancing the professionally important personality traits of future doctors. It emphasises the prevention of aggressive behaviour, the cultivation of conflict resolution skills, and the promotion of effective communication with patients and colleagues, ultimately leading to an improvement in the quality of medical care.
Doing Theatre at School: Effective and Fun Learning
Authors: Valentini Manuela , Magazzino Clara
Published: September 2024

Introduction: the theatre arts within the school curriculum has sparked a growing interest in schools as they have unique qualities that can help teachers propose teaching methods and strategies to train subjects who are able to identify their feelings in social contexts, but also a way to attract students' attention and at the same time have an enjoyable and entertaining learning experience. Research aim: was to evaluate the effectiveness of using the arts within curricular learning through a literature review. In addition, a questionnaire was administered to primary school teachers in Taranto, Italy, and its province, on the validity of the use of theatre at school. Evidence-based facts: the experience of theatre in education also enables students to explore help-seeking options. Even apart from explicit learning, there is evidence that engaging children and young people with the arts can have a positive impact on their mental health and well-being. Summary: This should be considered as a starting point for incorporating theatre practice into the school learning program, as it appears to be not far removed, in terms of education, from the school needs of the pupils themselves. The teachers interviewed themselves turn out to be, in this sense, still very restrained and tied to curricular activities to the detriment of the implementation of training interventions that are essential and geared to enhancing different skills.
Personality Determinants of the Sense of Loneliness among Prisoners in the Five-Factor Model of Personality
Authors: Wojnarska Anna Danuta , Kirenko Janusz
Published: September 2024

Introduction: The sense of loneliness and loneliness are phenomena connected with human social development and they demand interdisciplinary analysis of philosophical, sociological and psychoeducational types. Research Aim: The aim of the paper is the analysis of the personality conditioning of loneliness in the context of the Bog Five theory. Method: Two groups of 42 people were investigated: one group consisted of the first time sentenced, second consisted of recidivists. They were investigated with two questionnaires: UCLA and NEO-FFI. Results: Significant differences were found between groups in extraversion, conscientiousness, and low belief of belonging to a social group. Higher scores were achieved by recidivists. More significant correlations between variables of Big Five and loneliness dimensions were obtained in the group of first time sentenced, whereas in the group of recidivists significant correlations concerned only extraversion. Models of multiple regression revealed significant prediction power of agreeableness for almost all examined aspects of loneliness. The same dependence concerning neurotism and conscientiousness was revealed but it was observed less often. Conclusion: Obtained results suggest the need of future exploration aimed at using them in the penitentiary resocialization.