bluuebunny/crossref_metadata_2025 huggingface dataset:
Gambaran Kriteria Robson pada Ibu Bersalin dengan Preeklampsia
Authors: Nurlaelasari Dewi , Dewi Andriana Kumala
Published: September 2023

AbstractPreeclampsia is hypertension in pregnancy which is associated with 2-8% of pregnancy-related complications worldwide. It causes 9-26% of maternal deaths in low-income countries and 16% in high-income countries. This study aims to determine the prevalence and characteristics of pregnant women with preeclampsia who underwent cesarean section based on Robson's criteria at Sumber Waras Hospital, West Jakarta. This research methodology uses a descriptive method with a cross-sectional design with a total sample of 55 women with preeclampsia who underwent caesarean section in 2020 at Sumber Waras Hospital, West Jakarta. The results of this study were the highest group 4 on the Robson criteria with 41.81%, while the lowest were groups 3, 6 and 9 with 1.81%. The conclusion of this study is that the prevalence of women giving birth with preeclampsia who undergo cesarean section at Sumber Waras Hospital, West Jakarta is 78.57% and shows that group 4 on Robson's criteria has the highest number.Keywords: Cesarean section; Preeclampsia; Robson's criteriaAbstrakPreeklampsia adalah hipertensi pada kehamilan yang berhubungan dengan 2-8% komplikasi terkait kehamilan di seluruh dunia. Ini menyebabkan 9-26% kematian ibu di negara-negara berpenghasilan rendah dan 16% di negara-negara berpenghasilan tinggi. Penelitian ini bertujuan untuk mengetahui prevalensi serta karakteristik ibu bersalin dengan preeklampsia yang menjalani seksio sesarea berdasarkan kriteria Robson di RS Sumber Waras Jakarta Barat. Metodologi penelitian ini menggunakan metode deskriptif dengan desain penelitian potong lintang dengan jumlah sampel sebanyak 55 ibu bersalin dengan preeklampsia yang menjalani seksio sesarea pada tahun 2020 di RS Sumber Waras Jakarta Barat. Hasil penelitian ini yang tertinggi adalah kelompok 4 pada kriteria Robson dengan 41,81%, sedangkan yang terendah yaitu kelompok 3, 6 serta 9 dengan 1,81%. Kesimpulan dari penelitian ini adalah prevalensi ibu bersalin dengan preeklampsia yang menjalani seksio sesarea di RS Sumber Waras Jakarta Barat adalah 78,57% serta menunjukan bahwa kelompok 4 pada kriteria Robson memiliki jumlah yang paling tinggi.Kata kunci: Kriteria Robson; Preeklampsia; Seksio sesarea
Manfaat Maternal Early Obstetric Warning Score (MEOWS) dalam Memprediksi Lama Perawatan pada Pasien Preeklamsia Berat di RSUP Dr. Sardjito
Authors: Sulistianto Sulistianto , Siswishanto Rukmono , Attamimi Ahsanudin
Published: September 2023

Latar Belakang: skor MEOW sangat penting untuk menilai kondisi klinis pasien dengan adanya perubahan tanda vital selama pasien dirawat. Adanya perubahan ini akan berpengaruh terhadap lama perawatan pasien preeklamsia berat. Namun saat ini belum ada penelitian mengenai hubungan skor MEOW dengan lama perawatan pasien preeklamsia berat yang dirawat di rumah sakit.Tujuan: Mengetahui apakah terdapat hubungan antara skor MEOW dan lama perawatan pasien preeklamsia berat.Metode: Desain penelitian ini adalah kohort retrospektif. Subjek penelitian adalah pasien hamil dengan diagnosis preeklamsia berat sesuai dengan kriteria inklusi dan kriteria eksklusi di RSUP Dr. Sardjito sejak Juli 2020 sampai dengan Juni 2021 dengan mengambil data dari rekam medis.Hasil dan Pembahasan: Dari 86 subjek penelitian didapatkan 78 sampel yang memenuhi kriteria inklusi dan eksklusi. Berdasarkan karakteristik subjek penelitian didapatkan paritas primigravida (69,2%), obesitas (51,3%) dan riwayat hipertensi (53,8%). Hal ini sesuai referensi bahwa faktor resiko preeklamsia berat yaitu primigravida, obesitas dan riwayat hipertensi. Hasil dari ROC yaitu nilai AUC 0,878 dengan p = 0,001 dan CI 95% (0,745 – 1). Penentuan nilai cut off point skor MEOW yaitu 8,5 atau 9 dengan sensitivitas 92%, spesifisitas 71% dan Youden Index tertinggi = 0,631. Lama perawatan antara pasien dengan skor MEOW ≥9 dan pasien dengan skor MEOW <9 berbeda secara signifikan (p <0,05). Skor MEOW ≥9 memiliki lama perawatan lebih lama dibandingkan skor MEOW <9. Tidak ada perbedaan bermakna antara variabel luar dan skor MEOW (p >0,05). Tidak ada perbedaan bermakna antara variabel luar dan lama perawatan (p >0,05).Kesimpulan: Pasien preeklamsia berat yang mengalami persalinan di RSUP dr. Sarjito dengan skor MEOW tinggi memiliki lama perawatan yang lebih lama dibandingkan dengan skor MEOW rendah.Kata Kunci: MEOWS; preeklamsia berat; lama perawatan.
Luaran Maternal pada Ibu Hamil dengan Covid-19 di Daerah Istimewa Yogyakarta Studi Kohort Retrospektif
Authors: Wahyuningtyas Utami Kartika , Taufiqur Rachman Irwan , Siti Nurdiati Detty
Published: September 2023

Background: Coronavirus is a disease at the end of 2019 caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) which now was declared a pandemic by WHO on March 11, 2020. Indonesia reported the first case of COVID-19 on March 2, 2020 and the number still increase until now. The studies of SARS-CoV-2 infection on pregnancy and maternal outcomes are still uncertain since evidence regarding the disease is still ongoing.  Moreover, the pregnant women have a higher risk of morbidity and mortality than the general population.Objective: This study aimed to determined the relationship among COVID-19 in pregnancy with maternal outcome at YogyakartaMethods: This is a retrospective cohort study. The subjects were pregnant women who were diagnosed confirm COVID-19. The research subjects were taken     at Dr. Sardjito Hospital and Akademik UGM Hospital from March 2020 to August 2021.Results and Discussion: Among all 436 research subjects, obtained 340 sampels that met the criteria for analysis. The characteristics of subjects showed patients with aged >35 years (58.24%), and gestational age ≥37 weeks (79.41%). There were correlated significantly  between confirmed symptomatic COVID-19 in pregnant women with prematurity (RR 2,42, CI 95% 1,44–4.04), requiring ICU (RR 53.89, CI 95% 3.33–870.45), length of stay (RR 1.97, CI 95% 1,05–3,68), and maternal mortality maternal (RR 38.08, CI 95% 2,34–619,83) compared with asymptomatic COVID-19. There was no correlated significantly   (p>0.05) between COVID-19 in pregnancy with mode of delivery.  Age, obesity, hypertension and diabetes mellitus have no correlated significantly  with maternal outcomesConclusion: Pregnancy as an independent risk factor for symptomatic COVID-19 that is likely independent of other comorbidities. Pregnant women who symptomatic COVID-19 increase the risk of worse maternal outcome compare with asymptomatic COVID-19. The mode of delivery decided based on medical and obstetric indication. Keywords : COVID-19; pregnancy; co-morbidities; maternal outcomes
Perbandingan Kadar Vitamin D antara Wanita dengan Surgical Menopause Post Kemoterapi dan Wanita Menopause Alami di Yogyakarta
Authors: Pratiwi Rosinta , Dewanto Agung , Kusumanto Ardhanu
Published: September 2023

Latar Belakang: Menopause merupakan periode berhentinya haid akibat penurunan produksi hormon pada wanita. Menopause dapat terjadi secara alami maupun karena prosedur medis pengangkatan kedua ovarium mau sebab lainnya seperti obat-obatan. Wanita yang mengalami menopause dini karena surgical menopause akan mengeluhkan gejala menopause yang lebih berat karena perubahan hormon secara mendadak.  Pasien dengan surgical menopause akibat kanker seringkali mendapatkan kemoterapi adjuvant yang akan menyebabkan penurunan kadar vitamin D, dimana vitamin D diketahui berperan penting dalam mengurangi keluhan menopause. Tujuan: Mengetahui perbandingan kadar vitamin D pada pasien surgical menopause post kemoterapi dan wanita menopause alami. Latar Belakang: Menopause merupakan periode berhentinya haid akibat penurunan produksi hormon pada wanita. Menopause dapat terjadi secara alami maupun karena prosedur medis pengangkatan kedua ovarium mau sebab lainnya seperti obat-obatan. Wanita yang mengalami menopause dini karena surgical menopause akan mengeluhkan gejala menopause yang lebih berat karena perubahan hormon secara mendadak.  Pasien dengan surgical menopause akibat kanker seringkali mendapatkan kemoterapi adjuvant yang akan menyebabkan penurunan kadar vitamin D, dimana vitamin D diketahui berperan penting dalam mengurangi keluhan menopause. Tujuan: Mengetahui perbandingan kadar vitamin D pada pasien surgical menopause post kemoterapi dan wanita menopause alami. Metode: Penelitian analitik dengan desain kohort retrospektif untuk membandingkan kadar vitamin D antara 2 kelompok, yaitu kelompok wanita dengan surgical menopause yang sudah dikemoterapi dan wanita post menopause alami. Penilaian kadar vitamin D dilakukan pada satu sampai dua tahun pada kelompok pasca ooforektomi bilateral dan satu sampai dua tahun pasca haid terakhir pada kelompok menopause alami. Perbandingan rerata kadar vitamin D antar 2 kelompok dilakukan dengan uji statistika komparatif menggunakan Independent T-Test. Hasil dan Pembahasan:  Rerata dan standar deviasi kadar vitamin D pada kelompok surgical menopause post kemoterapi adalah 14,07 + 5,49 ng/mL sedangkan kelompok menopause alami adalah 17,30 ± 6,92 ng/mL dengan nilai p=0,167. Kesimpulan: Tidak terdapat perbedaan signifikan pada rerata kadar vitamin D antara kelompok surgical menopause post kemoterapi dan post menopause alami.Kata Kunci: surgical menopause; menopause alami; ooforektomi bilateral; vitamin D.
Gangguan Stres Pasca Trauma pada Kasus Pelecehan Seksual: Case Report
Authors: Darmayasa I Made , Natanael Raymond Josafat Major
Published: September 2023

AbstrakLatar belakang: Tindakan kekerasan atau pelecehan seksual semakin banyak dilaporkan pada beberapa tahun belakangan ini, terutama pada perempuan. Bukan saja pada tingkat global, tetapi juga nasional maupun lokal. Tindakan kekerasan atau pelecehan seksual berpotensi menimbulkan trauma yang mendalam bagi korban, depresi maupun gangguan kejiwaan yang lain.Metode: Studi kasus tentang pelecehan seksual yang menimbulkan gangguan stress pasca trauma.Hasil dan Pembahasan: Seorang perempuan 18 tahun, masih sekolah ditingkat SMA mengeluh ketakutan setelah mengalami beberapa kali kekerasan atau pelecehan seksual baik oleh orang terdekat maupun orang yang tidak dikenal. Dengan pendekatan multiaksial korban diagnosis dengan Gangguan Stress Pasca-Trauma. Terkonfirmasi korban mengalami Depresi berat menggunakan Hamilton Depression Rating Scale dan Depresi ekstrim dengan menggunakan Beck Depression Inventory. Teridentifikasi beberapa faktor seperti: Adanya konflik dan kekerasan dalam keluarga, pernah menjadi korban atau perbuatan seksual sebelumnya, lingkungan keluarga yang tidak mendukung secara emosional, hubungan orang tua-anak yang buruk, dan kemiskinan. Dilakukan tatalaksana secara komprehensif menggunakan pendekatan multidisilin. Secara Farmakologi diberikan Risperidon 1 miligram tablet tiap 24 jam per-oral pagi, dan Sertraline 25 miligram tablet tiap 24 jam per-oral malam. Korban juga mendapatkan psikoterapi, edukasi, dan dukungan sosial. Selanjutnya terhadap korban dilakukan pemantauan secara berkala.Kesimpulan: Kekerasan atau pelecehan seksual rentan menimbulkan Gangguan Stress Pasca-Trauma sehingga memerlukan pendekatan multidisiplin dan tatalaksana komprehensif. Mulai dari melakukan anamnesis untuk konfirmasi diagnosis, tatalaksana dan pemantauan.Kata kunci: pelecehan seksual pada perempuan, Gangguan stress Pasca-Trauma, Depresi.
Perbandingan Karakteristik dan Luaran Maternal pada Unexpected Spektrum Placenta Akreta saat Pandemi Covid -19
Authors: Cahyanti Ratnasari Dwi , Dewantiningrum Julian , Pramono Besari Adi , Larasati Irene Astrid , Wiyati Putri Sekar
Published: September 2023

Latar belakang: Pandemi COVID-19 mempengaruhi sistem pelayanan kesehatan di dunia. Kegawatan maternal yang diakibatkan oleh Spektrum Placenta Akreta (SPA) menjadi tantangan di bidang obstetri, khususnya dalam kinerja multidisplin tim dan dukungan sumber daya fasilitas kesehatan.Tujuan: Membandingkan karakteristik dan luaran dari pasien dengan unexpected dan expected SPA saat pandemi COVID-19.Metode: Desain penelitian secara cross-sectional. Pengambilan sampel kasus SPA secara consecutive sampling dari data rekam medis RSUP Dr. Kariadi, Semarang, pada periode 2020 – 2021.Hasil dan Pembahasan: Limapuluh tiga dari 154 kasus (34,42%) merupakan unexpected SPA. Tidak terdapat perbedaan karakteristik yang meliputi umur, indeks massa tubuh, jumlah riwayat sectio cesarea, jumlah riwayat placenta previa, cara persalinan dan kerjasama tim. Jumlah perdarahan dan kebutuhan transfusi darah yang diberikan tidak terdapat perbedaan pada kedua kelompok. Terdapat risiko untuk Cesarean histerektomi pada unexpected SPA (adjusted OR 4,13 (1,31-55,02)). Case Fatality Rate (CFR) pada unexpeted 5,67%, sedangkan pada expected 0,9%. Pada kasus unexpexted SPA didapatkan 3 kasus dengan terkonfirmasi COVID-19 dan meninggal.Kesimpulan: Tata kelola spektrum placenta akreta di RSUP Dr. Kariadi selama pandemi COVID-19 tidak terdapat perbedaan luaran maternal pada kasus unxpected dan expected dan didapatkan kualitas pelayanan optimal dengan CFR yang rendah.Kata kunci: Spektrum Placenta Akreta (SPA), unxpected dan expected, pandemi COVID-19, luaran maternal
In-class Activities for Improving English Listening and Speaking in Cross Cultural Communication
Authors: Hu Yuxiu , Zhang Xinting
Published: September 2023

This study presents a comprehensive framework for designing in-class activities aimed at enhancing English listening and speaking skills in cross-cultural communication in the age of self media. The study emphasizes the crucial connection between in-class activities and the broader curriculum design, giving special importance to the alignment of activities with course objectives. Drawing from established principles of curriculum design, constructivist theories, and key findings in cross-cultural communication, the study outlines a systematic approach that consists of four distinct steps-recognizing cultural self-awareness, interpreting and explaining foreign cultures, comparing and contrasting cultural elements, and evaluating cross-cultural content. Overall, the study offers a structured and practical approach to designing in-class activities that align with the objective of improving English listening and speaking skills in the context of cross-cultural communication under the help of self-media. By following this comprehensive framework, educators and students alike can enhance their cross-cultural competence and contribute to more effective cross-cultural communication teaching and learning.
Technical requirements of a convenience food to meet the demands of a customer segment
Authors: Cardi Peccinelli Marianna , Libório Romanelli Thiago , Ferreira de Souza Vieira Thais Maria , Milan Marcos
Published: September 2023

Meeting customer needs is a step towards achieving the success of a product or service. As dynamic lifestyles have been taking place in society, the demands regarding food have changed, and the easiness of preparation and healthiness have become demanded by a segment of customers. Convenience foods are examples to fulfill these changes and stand out for their practicality, but with reservations about healthiness. Considering these new demands and the importance of incorporating customer needs into the product, this study aimed at defining the technical characteristics of an instant noodles that meets consumer demands in terms of practicality and healthiness using the quality function deployment method. A questionnaire was developed and applied to a group of target customers with higher acceptability and receptivity to this type of product. This group was chosen through factorial and cluster analysis. The technical requirement that most impacted customer needs was the amount of protein (mushroom), which met the health requirement, but had a strong influence on the final price of the product.
Prognostic value of MRD dynamics during maintenance therapy for multiple myeloma in the TOURMALINE-MM3 and -MM4 trials
Authors: Paiva Bruno
Published: September 2023

Dr Paiva presents the prognostic value of MRD dynamics during maintenance therapy of patients with multiple myeloma enrolled in the TOURMALINE-MM3 and -MM4 trials.
E3 ubiquitin ligase components in GtoPdb v.2023.2
Authors: Faccenda Elena , Layfield Robert
Published: September 2023

Ubiquitination (a.k.a. ubiquitylation) is a protein post-translational modification that typically requires the sequential action of three enzymes: E1 (ubiquitin-activating enzymes), E2 (ubiquitin-conjugating enzymes), and E3 (ubiquitin ligases) [30]. Ubiquitination of proteins can target them for proteasomal degradation, or modulate cellular processes including cell cycle progression, transcriptional regulation, DNA repair and signal transduction. E3 ubiquitin ligases, of which there are >600 in humans, are a family of highly heterogeneous proteins and protein complexes that recruit ubiquitin-loaded E2 enzymes to mediate transfer of the ubiquitin molecule from the E2 to protein substrates. Target substrate specificity is determined by a substrate recognition subunit within the E3 complex. E3 ligases are being exploited as pharmacological targets to facilitate targeted protein degradation (TPD), as an alternative to small molecule inhibitors [3], through the development of proteolysis targeting chimeras (PROTACs) and molecular glues.
Relatos de vida como espacio para la construcción de memorias locales
Authors: Corbacho Verónica B.
Published: September 2023

El trabajo describe el uso de herramientas teóricas y metodológicas propias de las entrevistas biográficas y cómo la elaboración de relatos se constituye en un espacio intersubjetivo de construcción de conocimiento. Para la investigación se realiza un estudio cualitativo, con foco en narrativas biográficas elaboradas a partir de una pauta de interrogantes. La entrevista se realizó con una abuela española octogenaria, a fin de evaluar el impacto provocado por la pandemia y sus restricciones. Se basó en los cambios provocados sobre el desarrollo y la organización de su vida, qué sentimientos y recuerdos se despertaron, y qué sentido se les otorgó. Tanto desde su individualidad, como desde el efecto sobre el grupo de adultos mayores. En los discursos se recuperan eventos que permiten la construcción de ejes espaciotemporales que se imbrican con ejes afectivos como el desarraigo, el sometimiento, la posición de la mujer, y la autonomía. A partir de la relación dinámica entre entrevistador y entrevistado, de la interacción dialógica y la reflexividad se va produciendo un discurso complejo, multidimensional, desorganizado y sin orden cronológico. El entrevistado, cuando ordena el discurso, le va dando forma y sentido a partir de la metabolización de su experiencia y de los acontecimientos que considera relevantes.
Microbial-Derived Uremic Toxins: Role in the Pathogenesis of Comorbidities in Patients with Chronic Kidney Disease
Authors: Pyatchenkov M. O. , Vlasov A. A. , Sherbakov E. V. , Salikova S. P.
Published: September 2023

Аim: to analyze the significance of microbial-derived uremic toxins (MDUT) in the pathogenesis of comorbidities in patients with chronic kidney disease (CKD).

Key findings. Increased excretion of nitrogen metabolism products into the intestines of patients with CKD is associated with uremic dysbiosis; changes in the metabolic activity of the gut microbiota and the leaky gut syndrome; which largely cause the accumulation of MDUT in the internal environment of the body: indoxyl sulfate; p-cresyl sulfate; trimethylamine-N-oxide; etc. The results of recent studies allow to consider these metabolites as an independent risk factor for adverse outcomes in people with CKD due to the progression of renal dysfunction to the terminal stage; as well as frequent cardiovascular; neurological; bone mineral; nutritional and other complications.

Conclusion. MDUT are one of the key modulators of the pathogenetic relationship between the gut and kidneys. Therapeutic manipulations with intestinal microbiota can be considered a promising strategy for preventing complications associated with uremia.
Neuro-economics and Strategic Decisions: The Impact on Financial Sustainability of Multinational Enterprises
Authors: Asuquo - Utuk Kokoete
Published: September 2023

More than ever, engaging a multidisciplinary approach in decision-making displays an arsenal ofcapacity necessary for success across managerial concerns in all sectors of the economy. Psychology andeconomics capturing human behaviors form part of this interdisciplinary research that spans the years thoughmany are far from this reality. The paper shows the impact of neuro-economics on strategic financialdecisions in multinational enterprises deploying theories of decisions, utility, and expectations across MNCsin the media industry in Nigeria while addressing the effects of emotions affecting advertising outcomes andbranding, and financial decisions building the theoretical framework from resources from Google Scholar andScopus search engines. Utilizing five MNCs as a sample in a population of 15 registered media firms inNigeria, the study uses grounded theory methodology and focus group discussions to uncover the reality ofemotional influence on strategic decisions and multiple regression analysis to test for the statisticalsignificance of independent variables on the dependent variable. The output shows that neuro-economicscontributes significantly to all economic decision-making in all sectors, including the media industry.Although research generalization is challenging due to economic variations in different markets, the reportposts resourceful information for policy-making decisions, productivity, and wealth creation.
Hermeneutic as a Means of Sustaining Peace
Authors: Olayinka Akintayo Sunday
Published: September 2023

This paper presents the roles the interpretations of religion (or texts)
and understanding of religion play in the sustainability of peace among
the Yorùbá people of southwest Nigeria. The Yorùbá’s way of interacting
and practising religion has remained moderately amiable over the last
two centuries when compared with other communities in Nigeria. With
attention on Yorùbá Christians and Muslims, this author examines some
specific religious concepts and values that have been useful in guiding
the two religions to retain their peace or return to dialogue table to
refrain from violence and keep the peace. The paper argues that the
interpretations of some religious terms and values among the Yorùbá
enhance their pursuance of peace.

Please note: The bulk of this article is taken from chapter 8
of the author’s doctoral dissertation with a few amendments to suit this
journal.
FAULT DETECTION AND LOCATION BASED SVM FOR THREE PHASE TRANSMISSION LINES APPLYING POSITIVE SEQUENCE FAULT COMPONENTS
Authors: Shingade Ganesh , Shah Sweta
Published: September 2023

Transmission lines are an imperative element of the modern power systems. Any faults in them can cause an undesirable interruption in power supply. Precise analysis of these faults is important in-order to ensure an incessant supply of power. For this purpose, fault detection and classification are needed to clear any such faults and re-establish the system to maintain its normal operation. In this paper, a novel integrated approach of protective relaying with enhanced support vector machine algorithm has been adopted for detecting faults and its location estimation in long transmission line. The proposed scheme is successfully able to detect and classify different symmetrical and unsymmetrical faults along with some peculiar cases related to High Impedance Faults (HIF) and evolving faults, current transformer (CT) saturation/ capacitive voltage transformer (CVT) transient, close-in faults, swing condition, source strength variation, etc. The comparative analysis with recent proposed techniques declared the potentiality and robustness of the scheme
Gospodarowanie różnorodnością biologiczną na terenach leśnych włączonych do sieci Natura 2000 - zarys koncepcji
Authors: Płotkowski Lech , Gruchała Arkadiusz , Piekutin Jarosław
Published: September 2023

W pracy zajęto się opisem ekonomicznych warunków, w jakich idea ochrony bioróżnorodności leśnej może być skutecznie realizowana. Przede wszystkim skoncentrowano się na nowych formach regulacji gospodarki zasobami leśnymi mających na celu zachowanie i pomnażanie różnorodności biologicznej na terenach leśnych włączonych do sieci Natura 2000. W następnej kolejności dokonano analizy implikacji ekonomicznych związanych z wprowadzaniem różnego typu regulacji zarówno od strony metodologicznej, jak i dodatkowych kosztów, jakie obarczą gospodarstwo leśne w takich przypadkach. W tym celu wykorzystano znany w teorii zarządzania model Przełożony-Podwładny. Warto zaznaczyć, że w leśnictwie naszego kraju tego typu narzędzie analizy nie było dotychczas stosowane.
Handel rolno-spożywczy UE-Rosja - efekty rosyjskich sankcji
Authors: Rosińska-Bukowska Magdalena
Published: September 2023

Celem artykułu jest próba oceny wpływu zastosowania przez Rosję sankcji odwetowych wobec państw członkowskich UE (w tym Polski) na zmiany w strukturze i wielkości handlu rolno-spożywczego. Badanie przeprowadzono porównując obroty handlowe przed sankcjami (2013) oraz w analogicznym okresie po wprowadzeniu sankcji rosyjskich (2014). Podjęto próbę oceny wpływu sankcji na wartość i strukturę obrotów handlowych państw członkowskich UE, będących głównymi eksporterami na rynek rosyjski. Przedstawiono ujęcie sektorowe, uwzględniające poszczególne sekcje eksportu według Standard International Trade Classification (SITC) oraz szczegółową analizę skutków sankcji wobec polskiego rynku rolno-spożywczego.
Zmiany w specjalizacji gospodarstw starych i nowych krajów członkowskich UE
Authors: Błażejczyk-Majka Lucyna , Kala Radosław
Published: September 2023

W przeprowadzonym badaniu, obejmującym okres 2004-2012, za obiekty badawcze przyjęto 867 przeciętne gospodarstwa reprezentujące 116 regionów podzielonych na stare i nowe, w zależności w tego czy kraj macierzysty był członkiem UE przed czy dopiero po roku 2004. Badania oparto na danych pochodzących z europejskiego systemu FADN. W pracy podjęto próbę odpowiedzi na pytanie: czy po rozszerzeniu UE nastąpiła poprawa struktury gospodarstw rolnych poprzez większą ich specjalizację oraz czy ten proces jest bardziej intensywny w gospodarstwach z nowych regionów w porównaniu z gospodarstwami z regionów starych. Uzyskane wyniki wskazują na wyraźny spadek nakładów pracy w gospodarstwach z regionów nowych, szybszy niż w gospodarstwach z regionów starych. Ponadto odnotowano oznaki postępującej specjalizacji, ale też wyraźny wzrost wielkości produkcji w gospodarstwach z regionów starych, przy braku jasnej tendencji w regionach nowych.
Relacje cenowe w rolnictwie polskim a dochodowość gospodarstw rolnych i gospodarstw domowych rolników
Authors: Czyżewski Andrzej , Kryszak Łukasz
Published: September 2023

Głównym celem artykułu było zbadanie zależności między wskaźnikiem nożyc cen a różnymi kategoriami dochodu rolniczego. Wykorzystano dane GUS i FADN. Dochody rolniczych gospodarstw domowych pozostają niższe niż gospodarstw domowych ogółem, jednak nie są one silnie skorelowane ze wskaźnikiem nożyc cen. Dużo silniejsza zależność występuje natomiast między tym wskaźnikiem cen a dochodami z gospodarstwa rolnego mierzonymi wartością dodaną netto na jednego pełnozatrudnionego. Zależność ta wzrasta wraz z wielkością ekonomiczną gospodarstwa. Wzrost dochodów rolniczych wymaga podniesienia cen produktów rolnych, a następnie ich ustabilizowania. Nadwyżka ekonomiczna odpływa bowiem z rolnictwa m.in. na skutek mechanizmów cenowych. Osiągnięcie większej stabilności cen możliwe jest przez zwiększanie poziomu zintegrowania pionowego i poziomego w rolnictwie. Podstawowymi przejawami integracji w rolnictwie są kontraktacja oraz tworzenie Grup Producentów Rolnych.
Ligands containing 7-azaindole functionality for inner-sphere hydrogen bonding: Structural and photophysical investigations
Authors: Coles Alec , Wood Oskar , Hawes Chris
Published: September 2023

The synthesis, structural analysis and spectroscopic characterisation of three new 7-azaindole ligands is reported, alongside a novel 7-azaindole derived coordination polymer, with the aim of identifying new bridging ligands containing inner-sphere hydrogen bond donor functionality. Structural characterisation shows that the 7-azaindole hydrogen bond donor ability is significantly stronger in the hydrazone and imine species 1 and 2 compared to the amine 3, with the opposite trend evident in their hydrogen bond acceptor character. These findings are mirrored by the fluorescence spectroscopy results which show bimodal emission, characteristic of multiple emissive species related by proton transfer, is only evident in the amine species and not the more acidic imines. The polymeric copper(II) complex of the hydrazone ligand 1 shows the anticipated inner-sphere hydrogen bonding with a similar donor strength to that observed in the free ligand, which leads to deformation in the remainder of the coordination sphere. These results show the untapped versatility of the 7-azaindole functional group as a building block for ligands in coordination polymers and other multinuclear assemblies, with the potential for both stabilisation through hydrogen bonding and interesting photophysical properties.
A Maternal Western-Style Diet Impairs Skeletal Muscle Lipid Metabolism in Adolescent Japanese Macaques
Authors: Greyslak Keenan T. , Hetrick Byron , Bergman Bryan C. , Dean Tyler A. , Wesolowski Stephanie R. , Gannon Maureen , Schenk Simon , Sullivan Elinor L. , Aagaard Kjersti M. , Kievit Paul , Chicco Adam J. , Friedman Jacob E. , McCurdy Carrie E.
Published: September 2023

Maternal consumption of a Western-style diet (mWD) during pregnancy alters fatty acid metabolism and reduces insulin sensitivity in fetal skeletal muscle. The long-term impact of these fetal adaptations and the pathways underlying disordered lipid metabolism are incompletely understood. Therefore, we tested whether a mWD chronically fed to lean, insulin-sensitive adult Japanese macaques throughout pregnancy and lactation would impact skeletal muscle oxidative capacity and lipid metabolism in adolescent offspring fed a postweaning (pw) Western-style diet (WD) or control diet (CD). Although body weight was not different, retroperitoneal fat mass and subscapular skinfold thickness were significantly higher in pwWD offspring consistent with elevated fasting insulin and glucose. Maximal complex I (CI)-dependent respiration in muscle was lower in mWD offspring in the presence of fatty acids, suggesting that mWD impacts muscle integration of lipid with nonlipid oxidation. Abundance of all five oxidative phosphorylation complexes and VDAC, but not ETF/ETFDH, were reduced with mWD, partially explaining the lower respiratory capacity with lipids. Muscle triglycerides increased with pwWD; however, the fold increase in lipid saturation, 1,2-diacylglycerides, and C18 ceramide compared between pwCD and pwWD was greatest in mWD offspring. Reductions in CI abundance and VDAC correlated with reduced markers of oxidative stress, suggesting that these reductions may be an early-life adaptation to mWD to mitigate excess reactive oxygen species. Altogether, mWD, independent of maternal obesity or insulin resistance, results in sustained metabolic reprogramming in offspring muscle despite a healthy diet intervention.

Article Highlights

In lean, active adolescent offspring, a postweaning Western-style diet (pwWD) leads to shifts in body fat distribution that are associated with poorer insulin sensitivity. Fatty acid–linked oxidative metabolism was reduced in skeletal muscles from offspring exposed to maternal Western-style diet (mWD) even when weaned to a healthy control diet for years. Reduced oxidative phosphorylation complex I–V and VDAC1 abundance partially explain decreased skeletal muscle respiration in mWD offspring. Prior exposure to mWD results in greater fold increase with pwWD in saturated lipids and bioactive lipid molecules (i.e. ceramide and sphingomyelin) associated with insulin resistance.
Phenotypic Characterization of Congenital Hyperinsulinism Due to Novel Activating Glucokinase Mutations
Authors: Li Changhong , Juliana Christine A. , Yuan Yue , Li Ming , Lu Ming , Chen Pan , Boodhansingh Kara E. , Doliba Nicolai M. , Bhatti Tricia R. , Adzick N. Scott , Stanley Charles A. , De León Diva D.
Published: September 2023

The importance of glucokinase (GK) in the regulation of insulin secretion has been highlighted by the phenotypes of individuals with activating and inactivating mutations in the glucokinase gene (GCK). Here we report 10 individuals with congenital hyperinsulinism (HI) caused by eight unique activating mutations of GCK. Six are novel and located near previously identified activating mutations sites. The first recognized episode of hypoglycemia in these patients occurred between birth and 24 years, and the severity of the phenotype was also variable. Mutant enzymes were expressed and purified for enzyme kinetics in vitro. Mutant enzymes had low glucose half-saturation concentration values and an increased enzyme activity index compared with wild-type GK. We performed functional evaluation of islets from the pancreata of three children with GCK-HI who required pancreatectomy. Basal insulin secretion in perifused GCK-HI islets was normal, and the response to glyburide was preserved. However, the threshold for glucose-stimulated insulin secretion in perifused glucokinase hyperinsulinism (GCK-HI) islets was decreased, and glucagon secretion was greatly suppressed. Our evaluation of novel GCK disease-associated mutations revealed that the detrimental effects of these mutations on glucose homeostasis can be attributed not only to a lowering of the glucose threshold of insulin secretion but also to a decreased counterregulatory glucagon secretory response.

Article Highlights

Our evaluation of six novel and two previously published activating GCK mutations revealed that the detrimental effects of these mutations on glucose homeostasis can be attributed not only to a lowering of the glucose threshold of insulin secretion but also to a decreased counterregulatory glucagon secretory response. These studies provide insights into the pathophysiology of GCK-hyperinsulinism and the dual role of glucokinase in β-cells and α-cells to regulate glucose homeostasis.
Frequency and Causes of Nocturnal Alarms in Youth and Young Adults With Type 1 Diabetes Using a First-Generation Hybrid Closed-Loop System
Authors: Cobry Erin C. , Vigers Tim , Berget Cari , Messer Laurel H. , Wadwa R. Paul , Pyle Laura , Forlenza Gregory P.
Published: September 2023

Background

Meeting glycemic recommendations is challenging for youth with type 1 diabetes. Diabetes technology, including continuous glucose monitoring (CGM) and hybrid closed-loop (HCL) automated insulin delivery systems, significantly increase achievement of glycemic targets; however, many youth struggle to sustain use of early HCL systems. Nocturnal alarm fatigue contributes to disrupted sleep and device discontinuation.

Methods

We examined the frequency and causes of nocturnal (10:00 p.m. to 6:00 a.m.) alarms in pediatric patients (N = 76, median age 14.5 years [interquartile range 11.8–17.0 years, range 7–24 years]) starting on a first-generation HCL system in a prospective observational study. Device data were analyzed with linear mixed-effects models to examine change across time at 3-month intervals for 12 months.

Results

At baseline (HCL system in nonautomated mode), participants averaged 3.3 ± 0.6 alarms per night. In the 2 weeks after starting HCL (automated) mode, alarm frequency significantly increased to 5.4 ± 0.5 times per night (P <0.001). Alarm frequency decreased through the remainder of the observational period; however, CGM sensor and HCL system use also declined. The types of alarms were evenly distributed among sensor maintenance, sensor threshold, pump, and HCL-specific alarms.

Conclusion

These data show that HCL system nocturnal alarms are frequent and may be barriers to sleep quality and device use. Further research is needed to assess the impact of diabetes technology on sleep and to determine method to improve sleep quality with technology use.
MAD2-dependent insulin receptor endocytosis regulates metabolic homeostasis
Authors: Park Junhee , Hall Catherine , Hubbard Brandon , LaMoia Traci , Gaspar Rafael , Nasiri Ali , Li Fang , Zhang Hanrui , Kim Jiyeon , A. Haeusler Rebecca , Accili Domenico , I. Shulman Gerald , Yu Hongtao , Choi Eunhee
Published: September 2023

Insulin activates insulin receptor (IR) signaling and subsequently triggers IR endocytosis to attenuate signaling. Cell division regulators MAD2, BUBR1, and p31comet promote IR endocytosis upon insulin stimulation. Here, we show that genetic ablation of the IR-MAD2 interaction in mice delays IR endocytosis, increases IR levels, and prolongs insulin action at the cell surface. This in turn causes a defect in insulin clearance and increases circulating insulin levels, unexpectedly increasing glucagon levels, which alters glucose metabolism modestly. Disruption of the IR–MAD2 interaction increases serum fatty acid concentrations and hepatic fat accumulation in fasted male mice. Furthermore, disruption of the IR–MAD2 interaction distinctly changes metabolic and transcriptomic profiles in the liver and adipose tissues. Our findings establish the function of cell division regulators in insulin signaling and provide insights into the metabolic functions of IR endocytosis.

Article highlights

· Physiological function of IR trafficking on insulin sensitivity remains unresolved.

· Disruption of the IR-MAD2 interaction delays IR endocytosis and prolongs insulin signaling.

· IR-MAD2 controls insulin clearance and glucose metabolism.

· IR-MAD2 maintains energy homeostasis.
Studies on welding of thin stainless steel sheets with pulsed nanosecond fiber laser in butt joint configuration
Authors: Kumar Aniruddha , Neogy Suman , Keskar N. , Pushpalatha Devi Y. , Sathe D. B. , Bhatt R. B.
Published: September 2023

In this work, we report full penetration welding of 1.6 mm thick AISI 304L stainless steel sheets in a butt joint configuration using a pulsed nanosecond fiber laser of an average power of 200 W. The welding was carried out by a focused laser beam oscillating in a circular path. The effects of beam oscillation parameters, e.g., amplitude, frequency, and weld speed, on weld morphology and microstructure were studied. Electron back scattered diffraction was used to characterize the weld microstructure and to map the distribution of austenite and ferrite phases in the weld. The solidification mode of the weld was found to change from the equilibrium FA (Ferrite-Austenite) to AF (Austenite-Ferrite) to A (Austenite) on an increase in the cooling rate with a concomitant drop in the fraction of δ-ferrite. The welds were found to be without any cracks with the sporadic presence of porosities. The welds were found to be mechanically strong.
Estilos de aprendizaje y competencia digital en estudiantes de Enfermería en modalidad académica híbrida
Authors: Rojas Eccoña Pamela , Choque Cáceres Alina Anabel , Berduzco-Torres Nancy
Published: September 2023

El objetivo de este trabajo fue determinar la relación que existe entre los estilos de aprendizaje y la competencia digital en estudiantes de Enfermería de una universidad pública de Cusco en modalidad híbrida, 2022. Para ello, se empleó un enfoque cuantitativo, descriptivo-correlacional, de corte transversal, no experimental. La muestra estuvo conformada por 210 estudiantes. Para la recolección de datos se utilizaron los cuestionarios de Honey-Alonso de estilos de aprendizaje (CHAEA) y competencia digital del alumnado de educación superior (CDAES). Los resultados demuestran que el 47.1 % presentan un estilo de aprendizaje reflexivo de nivel moderado y el 39 % poseen una competencia digital media; asimismo, no se encontró una relación entre las variables de este estudio con un p > 0.05; sin embargo, hubo relación entre el sexo con los estilos reflexivo (p = 0.035) y pragmático (p = 0.042), y de la competencia digital con la procedencia (p = 0.046). En conclusión, no existe relación entre los estilos de aprendizaje y la competencia digital.
Influências na escrita do gênero abstract
Authors: Gil Beatriz , Aranha Solange
Published: September 2023

O objetivo deste artigo é mostrar a importância de se considerar as características intradisciplinares – inerentes a uma disciplina específica – e interdisciplinares – relação desta disciplina com outras que se encontram em intersecção com ela no fazer cientifico.  Para tanto, 24 abstracts publicados em dois periódicos A1 da área de Linguística foram analisados tanto retoricamente, com base no modelo de Gil (2011), quanto linguisticamente, com base nos estudos de Hyland (1998, 2005, 2002, 2012). Os resultados apontam que, apesar de a disciplina de Linguística estar inserida nas Ciências Humanas, nos periódicos analisados, ela apresenta interface com disciplinas biológicas, agregando crenças científicas dessas disciplinas em seu fazer científico e, consequentemente, influenciando na materialização retórica e na modalização – uso de hedges e boosters - dos abstracts publicados.
Análise das políticas e práticas de prevenção e combate ao assédio moral no trabalho: um estudo de caso em uma organização do Oeste Gaúcho
Authors: Saccardo dos Santos Meroli , Marzall Luciana Fighera , Domingues Vitória Sobeldia Dzwieleski
Published: September 2023

O tema assédio moral torna-se cada vez mais pautado dentro das organizações, pois afeta diretamente o desempenho e bem-estar dos colaboradores. Nesse sentido, a pesquisa objetivou analisar como uma empresa do comércio varejista de produtos alimentícios de Uruguaiana (RS) atua com relação ao combate do assédio moral no ambiente de trabalho. A pesquisa caracteriza-se como descritiva e qualitativa, com aplicação de formulário de entrevista semi-estruturado e técnica de análise de conteúdo. A partir do estudo foi possível identificar que o tema é pautado na organização e que ela possui políticas e ações relacionadas à prevenção e ao combate do assédio moral.
Photoelastic Stress in Mandibular Overdenture Retained by Two Implants
Authors: Trevizam Campana Júlia , Antônio de Arruda Nóbilo Mauro , Consani Rafael Leonardo Xediek
Published: September 2023

Objectives: The aim of this study was to verify the effect of occlusal and axial single loads in the photoelastic stress in overdenture retained by two implants placed in the anterior region of the mandible.
Materials and Methods: Occlusal load (10, 20, and 30 kgf) was exerted by the conventional maxillary complete denture in occlusion with the overdenture adapted in the mandibular photoelastic model. Axial single load was also exerted on the first left or right molar of the overdenture. Qualitative analysis was made in polariscope images and quantitative analysis by the FRINGES program.
Results: Qualitative analysis: The occlusal load showed similar stress in the region between the two implants. Axial single load induced in the first molars promoted stress in the implant apexes, and between the implant and mandible posterior region for the three loads. Quantitative analysis for occlusal load: 10 kgf (T = 265.03; N = 0.57); 20 kgf (T = 989.81; N = 2.11); 30 kgf (T = 1055.40; N = 2.26). Axial single load in the left molar: 10 kgf (T = 267.38; N = 0.57); 20 kgf (T = 270.07; N = 0.58) and 30 kgf (T = 281.84; N = 0.60). Axial single load in the right molar: 10 kgf (T = 952.14; N = 2.03); 20 kgf (T = 1038.58; N = 2.22); and 30 kgf (T = 926.92; N = 1.98).
Conclusions: Different photoelastic stress levels occurred in the overdenture retained by two implants when submitted to occlusal or axial single load in the first left or right molar.
Clinical Relevance: Artificial teeth intercuspation in the overdenture supported by two implants must have the same importance given to the vertical relationship to relieve the chewing effort.
Effective Communication in Deradicalization of Ex-Terrorism Convict
Authors: Mukorobin Ustad , Sulaiman Adhi Iman , Sutikna Nana
Published: September 2023

Terrorism always creates social, economic, and political chaos. Acts of terrorism in Indonesia are generally caused by religious beliefs and radical understandings held by the perpetrators. Terrorist convicts still maintain this belief, so a special approach is needed to run the deradicalization process effectively. Therefore, this research discusses issues regarding applying effective communication in the deradicalization process for terrorism convicts. An effective communication approach is positioned to support apparatus programs in the deradicalization process. This study uses a phenomenological approach to understand better the views and experiences of terrorism convicts undergoing the deradicalization process. The aim is to find and analyze effective forms of communication in the deradicalization process for terrorism convicts. The results of this study indicate that effective communication in the deradicalization process for terrorism convicts can be achieved through an approach that involves real and continuous attention, dialogue that is very careful about religious understanding, avoiding the act of extracting information about terrorist networks from the Police and BNPT; as well as people involved in handling terrorism; and applying an empathetic communication approach in embracing terrorism convicts, so that they do not return to the same environment and get a decent life. This approach also aims to ensure that former terrorism convicts feel cared for and valued by society.
Principles of Teaching Chinese Phraseological Units Based on a Cognitive Approach
Authors:   Peter the Great St. Petersburg Polytechnic University, Wang Linpeng
Published: September 2023

The article focuses on the principles of teaching Chinese phraseology based on the cognitive approach. The aim of the study is to characterize the most commonly used in the teaching practice principles of learning within the cognitive approach to help students better understand and apply Chinese phraseological expressions, which will contribute to improving their language skills, expanding the experience of intercultural communica-tion, awareness of the features of Chinese culture, embedded in the semantic field of stable language expres-sions. The work characterizes the most common of these principles, demonstrating a high efficiency of applica-tion on the material of the Chinese language. From the point of view of the cognitive approach the following principles are significant: the principle of reliance on consciousness, the principle of activation of cognitive pro-cesses, the principle of reliance on mnemonics, the principle of step-by-step learning, the principle of taking into account the cognitive styles of students. Conclusion dwells upon the fact that their use in practice with stu-dents significantly increases the effectiveness of teaching Chinese phraseology and the assimilation of foreign (Chinese) linguistic material by the objects of pedagogical influence.
Relationship with Parents as a Choice Factor for Adolescents’ Behavioral Strategy in Conflicts
Authors:   Moscow Pedagogical State University, Makarova Elena Yu. , Matyushina Lyubov A. ,   Moscow Pedagogical State University
Published: September 2023

The article investigates the relationship between parental attitudes in the adolescent’s perception and their choice of behavioral strategies in conflicts. It is deemed that in conflicts, adolescents’ strategies of rivalry and avoidance prevail, and the least expressed strategy is the strategy of cooperation. Parents’ educational strategy of authoritarian hypersocialization type increases the probability of adolescents’ choice of rivalry strategy in conflicts and reduces the prospect of choosing cooperation strategy. Parental attitudes of the type of underes-timating the importance of interests, feelings and hobbies of adolescents increases the likelihood of using the strategy of avoidance, escape from problems. Symbiosis-type relationships increase the likelihood that adole-scents will choose an adaptation strategy in conflict. On the contrary, relationships with parents according to the type of acceptance and cooperation contribute to the fact that adolescents in conflict situations tend to choose strategies of search for compromise, mutual agreements, cooperation.