bluuebunny/crossref_metadata_2025 huggingface dataset:
Lange Arbeits- und Pendelzeiten als Risikofaktoren für eine
depressive Symptomatik: Quer- und Längsschnittanalysen
Authors: Dragano Nico , Burr Hermann , Formazin Maren , Schulz Anika , Rose Uwe
Published: November 2023

Hintergrund Regelmäßige lange Arbeitszeiten und
Arbeitswege könnten negative Folgen für die psychische
Gesundheit haben. Die Studienergebnisse hierzu sind jedoch nicht eindeutig und
variieren nach Ländern. Die vorliegende Analyse prüft
für Deutschland Zusammenhänge zwischen langen Pendel- bzw.
Arbeitszeiten und depressiver Symptomatik.

Methode Die „Studie Mentale Gesundheit bei der Arbeit“
(S-MGA) ist eine Längsschnittuntersuchung einer Zufallsstichprobe
sozialversicherungspflichtig Beschäftigter. An der Basiserhebung nahmen
3 413 Personen teil, von denen 2 019 nach 5 Jahren erneut befragt wurden.
Wöchentliche Arbeits- und Pendelzeiten sowie Covariaten (Alter,
Geschlecht, berufliche Position, psychosoziale Arbeitsbedingungen) wurden zur
Basisuntersuchung erhoben. Depressive Symptome wurden zu beiden Messzeitpunkten
mit dem Patient Health Questionnaire (PHQ-9) erfasst. Um Zusammenhänge
zu untersuchen, wurden mittels logistischer Regression Odds Ratios mit
95%-Konfidenzintervallen unter Kontrolle von Covariaten kalkuliert. Es
wurden sowohl Querschnitts- (nur Basiserhebung) als auch
Längsschnittsanalysen (Basis- und Nacherhebung)
durchgeführt.

Ergebnisse Zur Basiserhebung hatten 7% der Beschäftigten
lange wöchentliche Arbeitszeiten von≥55 Stunden, weitere
8% arbeiteten 49 bis 54 Stunden. Im Querschnitt waren lange
Arbeitszeiten mit einer moderaten Erhöhung der depressiven Symptomatik
gegenüber der Normalarbeitszeit (35 bis<40 h/Wo)
assoziiert. Wenn die nach fünf Jahren neu auftretende depressive
Symptomatik betrachtet wurde, war der Zusammenhang für Arbeitszeiten von
55 und mehr Stunden deutlich ausgeprägt (Odds ratio (OR) 2,14;
95% Konfidenzintervall (KI) 1,11;4,12), nicht jedoch für
Arbeitszeiten von 49 bis 54 Stunden (OR 1,26, KI 0,65;2,43).
Beschäftigte, die wöchentlich zehn Stunden und mehr pendelten,
hatten im Querschnitt häufiger eine depressive Symptomatik (OR 1,83; KI
1,13;2,94) im Vergleich zur Referenzgruppe, die<2,5 Stunden pendelte.
Dieser Zusammenhang war im Längsschnitt nicht zu beobachten.

Schlussfolgerungen Die Ergebnisse legen nahe, dass überlange
Arbeits- und Pendelzeiten mit einer depressiven Symptomatik bei
Beschäftigten assoziiert sind, wobei die Effekte bzgl. Pendelzeit nur im
Querschnitt zu finden waren. Die Ergebnisse unterstreichen die Bedeutung der
Einhaltung von Arbeitszeitregelungen und der Vermeidung überlanger
Arbeitszeiten für die Mitarbeitergesundheit. Zur Rolle des Pendelns sind
weiterführende Untersuchungen nötig.
Empfehlungen für die Umgebungsuntersuchungen bei Tuberkulose
– Update 2023
Authors: Diel Roland , Breuer Cornelia , Bös Lena , Geerdes-Fenge Hilte , Günther Annette , Häcker Brit , Hannemann Jörg , Nienhaus Albert , Priwitzer Martin , Witte Peter , Bauer Torsten
Published: November 2023

Ziel der Umgebungsuntersuchung bei Tuberkulose ist neben der aktiven Fallfindung
das Aufdecken von Infektionsketten sowie die Verhütung der
Weiterverbreitung der Erkrankung. Dabei ist eine sorgfältige Auswahl der
Kontaktpersonen notwendig, die sich nach Art und Dauer des Kontaktes richtet, um
möglichst frisch Infizierte zu identifizieren und so den Nutzen einer
anschließenden präventiven Therapie zu erhöhen und
unnötige Testungen von Personen ohne Ansteckungsrisiko zu vermeiden.
Seit der letzten Überarbeitung der Empfehlungen zur
Umgebungsuntersuchung hat sich die Datenlage zum Einsatz von Interferon-y
release-Assays (IGRAs) bei Kindern weiterhin verbessert. Diese werden bevorzugt
in der Umgebungsuntersuchung von erwachsenen Kontaktpersonen eingesetzt.
Für Kinder unter 15 Jahren können sowohl IGRAs wie auch
weiterhin der Tuberkulin-Hauttest gleichwertig verwendet werden. Als
präventive Therapie bei nachgewiesener Infektion werden Rifampicin
für 4 Monate, Rifampicin und Isoniazid für 3 Monate oder aber
Isoniazid für 9 Monate empfohlen.

Ausführlich wird auf die Durchführung der Umgebungsuntersuchung
in verschiedenen Altersgruppen sowie rechtliche Rahmenbedingungen und
sozialmedizinische Aspekte und Herausforderungen eingegangen. Zusätzlich
werden Sonderfälle, wie die Umgebungsuntersuchung in Kitas, Schulen oder
in anderen Gemeinschaftseinrichtungen, separat dargestellt.
Solitär fibröse Tumoren der Orbita – klinisch-pathologische Charakteristik, Therapie und Prognose
Authors: Meier Chiara , Eckstein Anja , Baba Hideo Andreas , Sichward Lara Helena , Grabellus Florian , Li Yan , Ziegenfuß Christoph David , Mohr Christopher , Pförtner Roman
Published: November 2023

Hintergrund Aufgrund der Seltenheit der solitär fibrösen Tumoren ist das Ziel dieser Studie, die klinischen Charakteristika, die Therapie und das Outcome betroffener Patienten zu
beschreiben und Faktoren zu identifizieren, die mit einer Rezidiventwicklung einhergehen.

Methodik Retrospektive Studie einer Kohorte von 20 Patienten, die zwischen 2002 und 2023 in der Universitätsklinik für Mund-Kiefer-Gesichtschirurgie an einem orbitalen solitär
fibrösen Tumor operiert wurden. Demografische, klinische und therapeutische Daten sowie Ergebnisse aus der Tumornachsorge wurden gesammelt. Das Tumorvolumen und molekulargenetische
Mutationen wurden nachbestimmt.

Ergebnisse Das mediane Alter bei Erstoperation lag bei 49,5 Jahren. In 65% der Fälle war die linke Orbita betroffen. Das häufigste klinische Symptom war der Exophthalmus (80%).
Dieser wurde mit einer mittleren Seitendifferenz von 3,9 mm (Range 1 – 10 mm) angegeben. Die Tumoren waren vermehrt im Intra- und Extrakonalraum, im kraniolateralen Quadranten und mittleren
Drittel lokalisiert. Die Tumorvolumina lagen im Median bei 7,66 cm³ (Range 2,15 – 12,57 cm³). Bei allen Patienten wurde die Diagnose durch pathologische Untersuchungsmethoden gestellt. Alle
molekulargenetisch untersuchten Tumoren wiesen eine NAB2-STAT6-Mutation auf. Am häufigsten detektiert wurde die Fusion NAB2 Exon 4 – STAT6 Exon 2. Alle Patienten wurden initial über eine
frontolaterale Orbitotomie behandelt. Bei 35% (n = 7) kam es zu einer unvollständigen Resektion (R1-Status). Die Rezidivrate lag bei 25% (n = 5) mit einem medianen krankheitsfreien Intervall
von 45,5 Monaten (Range 23 – 130). 80% (n = 4) der Rezidive wurden initial R1-reseziert.

Schlussfolgerung Orbitale solitär fibröse Tumoren sind seltene Raumforderungen, die sich klinisch durch Zeichen der Bulbusverdrängung äußern. Die Diagnose wird durch histologische
und immunhistochemische Untersuchungen gestellt und kann mit einem molekulargenetischen Nachweis der NAB2-STAT6-Mutation bewiesen werden. Der therapeutische Goldstandard ist die vollständige
operative Entfernung. Eine R1-Resektion wird bei intrakonaler Lage sowie bei Lage im hinteren Orbitadrittel aufgrund der schwierigeren chirurgischen Erreichbarkeit wahrscheinlicher. Der
größte Risikofaktor für die Entwicklung eines Rezidivs im weiteren Krankheitsverlauf ist die unvollständige operative Entfernung. Späte Rezidive sind möglich, weswegen eine langfristige
Anbindung an eine spezialisierte Klinik notwendig ist.
Welche Faktoren sind mit einer Reruptur nach superiorer Kapselrekonstruktion der Schulter mit autologer langer Bizepssehne assoziiert? – Ein systematischer Review
Authors: von Knoch Marius , Hoffmann Daniel B. , Baums Mike H.
Published: November 2023

Die vorliegende Arbeit analysiert anhand eines systematischen Reviews Faktoren, die mit der Rerupturrate bzw. Nichteinheilung nach superiorer Kapselplastik mit autologer langer Bizepssehne bei der Rekonstruktion der Rotatorenmanschette der Schulter assoziiert sind.

Im September 2021 wurde eine systematische Durchsicht der U.S. National Library of Medicine/National Institutes of Health (PubMed) Datenbank und der Cochrane Library unter Anwendung der PRISMA-Checkliste durchgeführt. Arbeiten, die Daten zur Rerupturrate nach superiorer Kapselplastik mit autologer langer Bizepssehne bei der Rekonstruktion der Rotatorenmanschette der Schulter enthalten wurden identifiziert und analysiert. Ziel war die Identifikation von Faktoren, die mit einer Reruptur bzw. Nichteinheilung assoziiert sind. Das Verzerrungsrisiko wurde mit der Newcastle-Ottawa-Scale bestimmt.

Es konnten primär 86 Treffer generiert werden. Sieben Artikel aus den Jahren 2020 und 2021 entsprachen den Einschlusskriterien und wurden weitergehend inhaltlich analysiert. Der Evidenzlevel lag bei III–IV. Das Follow-up lag zwischen 12 Monaten (Minimum) und 24 bis 48 Monaten. Das Verzerrungsrisiko war nicht niedrig. Faktoren, die mit einer Reruptur bzw. Nichteinheilung assoziiert sein können, sind ein Diabetes mellitus und eine höhergradige fettige Degeneration von Subscapularis, Infraspinatus oder Teres minor als präoperative Faktoren. Nicht signifikant waren Alter, prozentuale Footprint-Abdeckung, Rupturgröße, Symptomdauer, Anzahl der Bündel, Durchführung einer Akromioplastik und Risskonfiguration. Unterschiedlich bewertet wurden Geschlecht, Verfettungsgrad des Supraspinatus und Läsionen der Subscapularissehne.

Gemäß Literatur mit aktuell noch kurzfristigen Beobachtungszeiträumen ist die superiore Kapselplastik mit autologer langer Bizepssehne auch bei massiven Rissen und älteren Patienten eine Behandlungsoption, wenn keine höhergradige fettige Degeneration von Subscapularis, Infraspinatus oder Teres minor vorliegen. Ein Diabetes mellitus ist prognostisch ungünstig. Eine zusätzliche Akromioplastik war bislang nicht mit besseren Ergebnissen assoziiert.
The Ploidy State as a Determinant of Hepatocyte Proliferation
Authors: Wilson Sierra R. , Duncan Andrew W.
Published: November 2023

The liver's unique chromosomal variations, including polyploidy and aneuploidy, influence hepatocyte identity and function. Among the most well-studied mammalian polyploid cells, hepatocytes exhibit a dynamic interplay between diploid and polyploid states. The ploidy state is dynamic as hepatocytes move through the “ploidy conveyor,” undergoing ploidy reversal and re-polyploidization during proliferation. Both diploid and polyploid hepatocytes actively contribute to proliferation, with diploids demonstrating an enhanced proliferative capacity. This enhanced potential positions diploid hepatocytes as primary drivers of liver proliferation in multiple contexts, including homeostasis, regeneration and repopulation, compensatory proliferation following injury, and oncogenic proliferation. This review discusses the influence of ploidy variations on cellular activity. It presents a model for ploidy-associated hepatocyte proliferation, offering a deeper understanding of liver health and disease with the potential to uncover novel treatment approaches.
Partnering with Patients and Families to Improve Diagnostic Safety through the OurDX Tool: Effects of Race, Ethnicity, and Language Preference
Authors: Bourgeois Fabienne C. , Hart Nicholas J. , Dong Zhiyong , Ngo Long H. , DesRoches Catherine M. , Thomas Eric J. , Bell Sigall K.
Published: November 2023

Background Patients and families at risk for health disparities may also be at higher risk for diagnostic errors but less likely to report them.

Objectives This study aimed to explore differences in race, ethnicity, and language preference associated with patient and family contributions and concerns using an electronic previsit tool designed to engage patients and families in the diagnostic process (DxP).

Methods Cross-sectional study of 5,731 patients and families presenting to three subspecialty clinics at an urban pediatric hospital May to December 2021 who completed a previsit tool, codeveloped and tested with patients and families. Prior to each visit, patients/families were invited to share visit priorities, recent histories, and potential diagnostic concerns. We used logistic regression to determine factors associated with patient-reported diagnostic concerns. We conducted chart review on a random subset of visits to review concerns and determine whether patient/family contributions were included in the visit note.

Results Participants provided a similar mean number of contributions regardless of patient race, ethnicity, or language preference. Compared with patients self-identifying as White, those self-identifying as Black (odds ratio [OR]: 1.70; 95% confidence interval [CI]: [1.18, 2.43]) or “other” race (OR: 1.48; 95% CI: [1.08, 2.03]) were more likely to report a diagnostic concern. Participants who preferred a language other than English were more likely to report a diagnostic concern than English-preferring patients (OR: 2.53; 95% CI: [1.78, 3.59]. There were no significant differences in physician-verified diagnostic concerns or in integration of patient contributions into the note based on race, ethnicity, or language preference.

Conclusion Participants self-identifying as Black or “other” race, or those who prefer a language other than English were 1.5 to 2.5 times more likely than their counterparts to report potential diagnostic concerns when proactively asked to provide this information prior to a visit. Actively engaging patients and families in the DxP may uncover opportunities to reduce the risk of diagnostic errors and potential safety disparities.
Evaluation of Parental Attitudes toward and Awareness of Oral Health in Children during the COVID-19 Pandemic
Authors: Shetty Amarshree A. , Rai Kavita , Mehrotra Deepshikha , Hegde Shipha , Kumara Kumara , Nayak U.S. Krishna , D'Souza Cynthia
Published: November 2023

Background Children are one of the most vulnerable groups to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and depend on their parents to supervise and maintain oral hygiene. During this pandemic, disease prevention through education and awareness of the parents is the only way to maintain a child's oral health; therefore, parents must have sufficient knowledge about the ongoing pandemic and its consequences on the oral cavity. This study aims to assess the parental attitudes toward and awareness of oral health of healthy children during the COVID-19 pandemic.

Methodology A questionnaire was circulated between May and September 2020 using simple random sampling of the parents of children aged between 6 and 12 years. The questions were close ended and divided into awareness and attitude-based sections so that the parents could choose the appropriate answer.

Results and Conclusion In the present study, 50% of the participating parents had the right attitude in challenging times like the pandemic and appropriate knowledge about the same.
Analytic and algebraic properties of dispersion relations (Bloch varieties) and Fermi surfaces. What is known and unknown
Authors: Kuchment Peter
Published: November 2023

The article surveys the known results and conjectures about the analytic properties of dispersion relations and Fermi surfaces for periodic equations of mathematical physics and their spectral incarnations.
A new instrument for interfacial dilational rheology
Authors: Huang Yun-Han , Frostad John M.
Published: November 2023

We present a new design for an interfacial dilational rheometer that can generate oscillatory dilational strain on a planar air–liquid interface. The strain is generated by a pneumatic mechanism involving a deformable film, which forms a circular barrier that can contract or expand under different pressures. The interfacial stress is measured using a Wilhelmy rod. We carefully examine and demonstrate the effects of potential sources of measurement error, including inertia, drag, buoyancy, flow from the bulk phase, and surface waves. The design avoids mixed deformations present in other instruments and is currently capable of accurate measurements at frequencies up to ∼0.1 Hz and dilational strains below 0.001, with potential for higher frequencies after further theoretical development. We demonstrate the integration of the interfacial dilational rheometer with a Langmuir trough by measuring the compression isotherm of an insoluble surfactant, stearic acid. Furthermore, we verify the capability of the interfacial dilational rheometer to perform frequency and amplitude sweeps and present the storage and loss moduli for a water-soluble surfactant, sodium dodecylbenzenesulfonate, at different concentrations.
Direct imposition of the wall boundary condition for weakly compressible flows in three-dimensional smoothed particle hydrodynamics simulations
Authors: Kim Imgyu , Park Hyung-Jun
Published: November 2023

This study introduces a novel method for imposing wall boundary conditions in smoothed particle hydrodynamics (SPH). SPH is a particle method based on the Lagrangian approach, primarily employed in fluid analysis as a part of numerical computation methods. Due to its ability to discretize space using particles, SPH excels in handling analyses of free surface flow or multiphase flow with intricate boundary surfaces. However, there is a drawback in modeling wall boundaries using particles, as resolving the particle deficiency problem necessitates multi-layered boundary particles to be arranged behind the wall boundary. This leads to difficulties in implementing complex shapes and adds computational expense. To address this issue, this study suggests the use of boundary segments for wall boundary modeling and specifically employs triangular segments for three-dimensional expansions. For robust application of boundary conditions, a method considering both Poisson's equation and geometric configurations is proposed. The proposed method is independent of the segment density, which facilitates efficient and flexible modeling. In addition, by imposing accurate boundary conditions from the wall, the stability and accuracy of the solution are enhanced. The performance of the proposed method is validated through numerical examples, compared with various analytical and experimental results.
Assisted heat transfer enhancement in non-Newtonian dielectric fluids based on ion conduction phenomena
Authors: Chen Di-Lin , Luo Kang , Yang Chun , Yi Hong-Liang
Published: November 2023

Electric field-assisted technologies show prospects for heat removal in electronic cooling scenarios with electro-thermo-convection phenomena. The coupled multiphysics field model is built using the finite volume method, and two configurations (depending upon the orientation of the electric field and gravity) are investigated for different shear-thinning properties and polymer elasticities. The results demonstrate a remarkable impact on the heat exchange efficiency, energy budget, plume morphology, and force distribution features. Two key partitions (buoyancy or Coulomb force-dominated regions) can be divided by Rayleigh number Ra ≤ 103 and electric Reynolds number ReE ≤ 1.57. A heat transfer boost of 13.9 times and 5.0 times was obtained in the two arrangements vs no electric reinforcement. The shear-thinning shows a noticeable positive contribution, and the heat transfer efficiency can be modulated by polymer elasticity within a wide parameter range. A detailed evaluation of the interfacial forces reveals the nonmonotonic curves of fluid convection and energy inputs.
Should crop sequences in Western Australia include more lupins?
Authors: d’Abbadie C. , Kharel S. , Kingwell R. , Abadi Ghadim A.
Published: November 2023

Context Reducing greenhouse gas emissions is an increasing priority for Australian grain producers. Could substituting lupins for canola, as a rotational break crop, enable farmers to reduce their emissions by less use of nitrogenous fertilisers? Aim This study aims to identify if replacing canola with lupins in rotations at a range of locations in Western Australia’s grainbelt is environmentally and economically attractive. Methods Bio-economic simulation modelling is used to examine the gross margins and emissions associated with replacement of canola by lupins at 14 locations in the grainbelt of Western Australia in various land use sequences. Key results Replacing canola with lupins unambiguously leads to reduced emissions in crop sequences at all locations considered. However, the higher gross margins from canola production cause lupins to only be a preferred break crop option at 4 of the 14 locations. Even with various plausible incentives to favour lupins, they remain economically unattractive at most locations other than those where lupins are well adapted to the environment. Conclusions Lupins’ current lack of commercial attractiveness for farmers limits its role in emissions reduction in the region’s farming systems. Implications The profitability of lupins needs to increase if lupins are to be widely readopted. This requires developing higher yielding lupin varieties, grain quality improvements, and policy changes to reward lower emission cereals. However, this study shows these changes, apart from yield improvement, are unlikely in the short term. At locations with suitable soils alternative pulse crops may offer higher gross margins whilst delivering emission reductions.
Immunolocalisation of aquaporins 3, 7, 9 and 10 in the epididymis of three wild ruminant species (Iberian ibex, mouflon and chamois) and sperm cryoresistance
Authors: Martinez-Madrid Belen , Martínez-Cáceres Carlos , Pequeño Belén , Castaño Cristina , Toledano-Díaz Adolfo , Bóveda Paula , Prieto Paloma , Alvarez-Rodriguez Manuel , Rodriguez-Martinez Heriberto , Santiago-Moreno Julián
Published: November 2023

Context In the epididymis, epithelial cells manage changes in the luminal environment for proper sperm maturation. Moreover, aquaglyceroporins, a subgroup of aquaporins (AQP), modulate the transport of water, glycerol and other small molecules in epithelial cells. Aims We aim to characterise the lining epithelium, quantify its cell composition and immunolocalise the aquaglyceroporins AQP3, AQP7, AQP9 and AQP10 alongside the epididymal ductus of three wild ruminant species, and to determine if species-specific differences could be associated with cauda sperm cryoresistance variations. Methods Epididymides from Iberian ibex (n = 5), mouflon (n = 5) and chamois (n = 6) were obtained. Cauda spermatozoa were collected and sperm parameters were analysed before and after freezing. Histology and immunohistochemistry of AQP3, 7, 9, 10 and T-CD3 were performed in the caput, corpus and cauda epididymal regions. Key results This work first describes the lining epithelium in Iberian ibex, mouflon and chamois epididymis along the three anatomical regions, consisting of principal, basal, apical, clear and halo cells. However, the percentage of each cell type differed in ibex compared to mouflon and chamois. The positive T-CD3 immunolabeling of all the halo cells confirmed their T-lymphocyte nature. Aquaglyceroporin expression patterns were similar among species, except for differences in AQP7 and AQP10 immunolocalisation in ibex. Species-specific differences in epididymal sperm cryoresistance were confirmed. Conclusions The epididymal epithelium of the three wild ruminants differ in their relative number of cell types and AQP immunolocalisation, which ultimately appears to affect cauda epidydimal spermatozoa cryoresistance. Implications Our study provides information on the relevance of the quantitative composition and AQP pattern expression in epididymal lining epithelium on sperm cryoresistance.
RGMb expression in goat uterine tissues: possible role of RGMb in the proliferation and apoptosis of endometrial epithelial cells
Authors: Xue Yang , Pei Xiaomeng , Xia Yuting , Chen Hengguang , Yu Hao , Wang Wei , Mao Dagan
Published: November 2023

Context Bone morphogenetic proteins (BMPs) play an important role in the uteri. Repulsive guidance molecule b (RGMb; a.k.a. Dragon) has been confirmed as the coreceptor of BMPs to function through drosophila mothers against decapentaplegic protein (Smads) and mitogen-activated protein kinases (MAPK) pathways. We hypothesise that RGMb regulates the uterine function through the Smads and MAPK pathways. Aims This study aimed to investigate the expression of RGMb in goat uteri and the potential role of RGMb in the endometrial epithelial cells (EECs). Methods The localisation of RGMb in goat uterine tissues was detected by immunohistochemistry (IHC), EECs were isolated and transfected with siRNA to investigate the role of RGMb in proliferation, and apoptosis. The expression levels of Smads and MAPK members was measured by western blot (WB) and real-time PCR (RT-PCR). Key results IHC showed that RGMb was localised in goat endometrial luminal cells, glandular epithelial cells, and circular muscle fibres, but not in stromal cells. RT-PCR results showed that treatment with RGMb siRNA suppressed the expressions of proliferation-related genes cyclin D1 (CCND1, P = 0.0291), cyclin-dependent kinase 2 (CDK2 P = 0.0107), and proliferating cell nuclear antigen (PCNA, P = 0.0508), leading to the reduced viability of EECs (P = 0.0010). WB results showed that the expression ratio of cleaved-caspase 3/caspase 3 (P = 0.0013) was markedly increased after RGMb siRNA transfection. Likewise, the level of phospho-extracellular signal-regulated kinase 1/2 (p-ERK1/2, P = 0.0068) and p-Smad1/5/8 (P = 0.0011) decreased significantly, while there were no appreciable differences in the level of p-P38 MAPK expression (P > 0.05). Conclusions RGMb might participate in the regulation of cell proliferation and apoptosis through Smads and ERK signalling pathways in goat EECs. Implications RGMb is involved in regulating the proliferation and apoptosis in goat endometrial epithelial cells.
Reported speech and its extensions in Beserman
Authors: Arkhangelskiy Timofey
Published: November 2023

This paper presents a descriptive account of reported speech, understood in terms of Spronck & Nikitina (2019), in Beserman (Uralic > Permic). Two phenomena are described in particular. First, it is demonstrated that, although Beserman generally prefers the direct speech strategy, the interpretation of indexicals in certain contexts may be affected by pragmatic factors. Second, Beserman allows for agreement mismatch between the subject and the predicate of the reported clause, known as “monstrous agreement”. This phenomenon has not been attested in Permic languages before. Apart from that, extended uses of two Beserman reported speech markers are described, whereby they convey pragmatic meanings that resemble English kind of or like. This semantic development reverses a well-known grammaticalization path that turns such pragmatic elements into reported speech markers. The study is based on both corpus and elicited data.
Supplementary comparison SIM.QM-S9 - biogas
Authors: Iglesias Cristiane R A C , Fioravante Andreia L , Ribeiro Claudia C , Mello Viviane F , Delgado Jorge Koelliker , Ramírez Flores Diana Gabriela , Murillo Francisco Rangel , Ramírez Nambo Carlos , Puelles Maria Mabel , Luján Chamorro Andrea , Sarzuri Yamil Acho
Published: November 2023

Main text

Supplementary comparison of amount fractions methane, nitrogen, carbon dioxide, hydrogen and oxygen (constituting a mixture of biogas).

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database https://www.bipm.org/kcdb/.

The final report has been peer-reviewed and approved for publication by the CCQM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Combination of anti-miR19a-3p polyplex plus doxorubicin for breast cancer in 2D culture and apoptosis assay in 3D spheroids in a microwell device
Authors: Kheiri Yeghaneh Azar Behjat , Nourbakhsh Mitra , Nasiraee M R , Mousavizadeh Kazem , Madjd Zahra , Ajoudanian Mohammad , Saeedi Sara , Vahabi Amirhossein , Hamblin Michael R , Karimi Mahdi
Published: November 2023

One of the most common cancers and a main cause of death worldwide among women is breast cancer (BC). Combination therapy is being widely investigated to reduce the dose of chemotherapy drugs, prevent the development of drug resistance, and improve treatment outcomes. Here we tested PEI-PBA-SAP-F15 (PPSF) polymeric nanoparticles to efficiently deliver a microRNA antagonist (anti-miR19a-3p) to BC cell lines. We evaluated the combination of anti-miR19a-3p plus doxorubicin (DOX) in both 2D and 3D cell cultures. We cultured 3D tumor spheroids in an innovative microfluidic device that was fabricated using a 3D printing system. The PPSF polyplexes had the correct size and zeta potential to efficiently transfer anti-miR19a-3p into MCF7 cells. The expression level of phosphatase and tensin homolog (PTEN), the attainment gene of microRNA-19a-3p was increased. PTEN up-regulation inhibited cell migration and caused cell cycle arrest. Apoptosis was also significantly induced with the combination treatment. Confocal microscopy studies revealed that the population of dead cells was in an important degree higher in MCF7 spheroids transfected with anti-miR19a-3p-PPSF plus DOX.
Theoretical investigation on the optical response of the artificial magnetic–plasmonic nanoclusters
Authors: Sun Jiajia , Shi Zongqian , Liu Xiaofeng , Zhong Mingjie , Chen Shuang , Ma Yuxin , Li Ruohan , Xin Shumin
Published: November 2023

Bottom-up nanofabrication, organizing colloidal nanoparticles into ordered clusters with structural and functional complexity, provides an alternative to yield nanometric smart structures unachievable in traditional top-down approaches. Those remarkable structures assembled of colloidal nanoparticles possessing optical properties feature exotic optical responses under the illumination of incident light, showing highly dependent on the particle separation, composition, and arrangement. Here, the nanoscale electromagnetic coupling in magnetic–plasmonic nanoparticle clusters is analyzed by using a 3D full-wave computational model, and the mechanism of the resonances in a split-ring resonator out of magnetic–plasmonic nanoparticle building blocks is also illustrated. In particular, once assembling those artificial molecules (split-ring resonator) into secondary metamaterial superstructures, such as split-ring resonator dimer and Y-shaped structures, a series of exotic optical responses are presented due to the greatly enhanced near-field coupling of nanoparticles and the generation of antiparallel ring currents in the asymmetrical superstructure, exhibiting flexible sensitivity to the changes of the surrounding environment. Besides, the H-shaped arrangement exhibits high sensitivity with Q = 50.5 at λ = 2.02 μm. Our finding provides a platform for yielding complex structures with flexible tunability of the optical response through arranging those assembled artificial molecules into complex secondary structures, allowing for the development of smart sensing devices.
DTMSgram: a novel optimal demodulation frequency band selection method for wheelset bearings fault diagnosis under wheel-rail excitation
Authors: Liu Wenpeng , Yang Shaopu , Liu Yongqiang , Gu Xiaohui
Published: November 2023

Due to the influence of the wheel-rail excitation and complex transmission path, the fault signature of wheelset bearings is often obscured by complex background noise, which brings great challenges to the adaptive determination of the informative frequency band (IFB) in envelope analysis. In this paper, the vibration response characteristics of the axle box under wheel–rail excitation are revealed through full-scale bench tests. The experimental results show that tread damage will provoke periodic transient impacts and it has an obvious sparsity in the frequency domain. Inspired by this feature, a DTMSgram method is proposed to enhance the fault feature components of vibration signals through time-domain and frequency-domain noise reduction technology, and improve the accuracy of demodulation frequency band selection. Firstly, the amplitude spectrum of different weight coefficients is used to preprocess the vibration signal and adjust the full band component of the vibration signal. Then, the autocorrelation process is performed on each layer’s narrowband filtered signal envelope in kurtogram to further reduce noise interference from a time-domain perspective. Moreover, a two-dimensional color map is constructed showing the normalized squared envelope spectrum of the IFBs determined simultaneously from the modified signal. Finally, the effectiveness of the proposed method is verified by simulated signal and experimental data of three sets of full-size wheelset bearing systems. The analysis results indicate this proposed method can effectively overcome the influence of complex wheel–rail excitation interference and can diagnose multi-source faults simultaneously.
Hybrid deep multi-task learning radiomics approach for predicting EGFR mutation status of non-small cell lung cancer in CT images
Authors: Gong Jing , Fu Fangqiu , Ma Xiaowen , Wang Ting , Ma Xiangyi , You Chao , Zhang Yang , Peng Weijun , Chen Haiquan , Gu Yajia
Published: November 2023

Objective. Epidermal growth factor receptor (EGFR) mutation genotyping plays a pivotal role in targeted therapy for non-small cell lung cancer (NSCLC). We aimed to develop a computed tomography (CT) image-based hybrid deep radiomics model to predict EGFR mutation status in NSCLC and investigate the correlations between deep image and quantitative radiomics features. Approach. First, we retrospectively enrolled 818 patients from our centre and 131 patients from The Cancer Imaging Archive database to establish a training cohort (N = 654), an independent internal validation cohort (N = 164) and an external validation cohort (N = 131). Second, to predict EGFR mutation status, we developed three CT image-based models, namely, a multi-task deep neural network (DNN), a radiomics model and a feature fusion model. Third, we proposed a hybrid loss function to train the DNN model. Finally, to evaluate the model performance, we computed the areas under the receiver operating characteristic curves (AUCs) and decision curve analysis curves of the models. Main results. For the two validation cohorts, the feature fusion model achieved AUC values of 0.86 ± 0.03 and 0.80 ± 0.05, which were significantly higher than those of the single-task DNN and radiomics models (all P < 0.05). There was no significant difference between the feature fusion and the multi-task DNN models (P > 0.8). The binary prediction scores showed excellent prognostic value in predicting disease-free survival (P = 0.02) and overall survival (P < 0.005) for validation cohort 2. Significance. The results demonstrate that (1) the feature fusion and multi-task DNN models achieve significantly higher performance than that of the conventional radiomics and single-task DNN models, (2) the feature fusion model can decode the imaging phenotypes representing NSCLC heterogeneity related to both EGFR mutation and patient NSCLC prognosis, and (3) high correlations exist between some deep image and radiomics features.
Review and recommendations on deformable image registration uncertainties for radiotherapy applications
Authors: Nenoff Lena , Amstutz Florian , Murr Martina , Archibald-Heeren Ben , Fusella Marco , Hussein Mohammad , Lechner Wolfgang , Zhang Ye , Sharp Greg , Vasquez Osorio Eliana
Published: November 2023

Deformable image registration (DIR) is a versatile tool used in many applications in radiotherapy (RT). DIR algorithms have been implemented in many commercial treatment planning systems providing accessible and easy-to-use solutions. However, the geometric uncertainty of DIR can be large and difficult to quantify, resulting in barriers to clinical practice. Currently, there is no agreement in the RT community on how to quantify these uncertainties and determine thresholds that distinguish a good DIR result from a poor one. This review summarises the current literature on sources of DIR uncertainties and their impact on RT applications. Recommendations are provided on how to handle these uncertainties for patient-specific use, commissioning, and research. Recommendations are also provided for developers and vendors to help users to understand DIR uncertainties and make the application of DIR in RT safer and more reliable.
A fully kinetic study on the plasma detachment processes in the collisionless propulsive magnetic nozzle
Authors: Chen Zhiyuan , Wu Kunlong , Wang Yibai , Ren Junxue , Wu Peng , Zhang Guangchuan , Li Min , Tang Haibin
Published: November 2023

A fully kinetic axisymmetric particle-in-cell model is employed to simulate and study the detachment processes of electrons in the propulsive magnetic nozzle. The detachment ratio is adopted to evaluate the extent to which the electrons detach from the magnetic field. The theoretical expression for the electron detachment ratio is derived and indicates that the electron detachment is driven by two mechanisms: inertia effect and gyro-viscous effect. The simulation results show that the detachment direction of electrons are outward in the upstream and inward in the downstream. In addition, the dominating detachment mechanisms in the upstream is inertia effect, while the gyro-viscous effect is equally, if not more, important as the inertia effect in the downstream, especially around the periphery of the magnetic nozzle under lower magnetic field strength. Moreover, the electron detachment is found to contribute to no more than 20% of the axial flux of plasma in the downstream, while the majority of it is caused by the electrons flowing along the magnetic field.
Thermodynamic state convertibility is determined by qubit cooling and heating
Authors: Theurer Thomas , Zanoni Elia , Maria Scandolo Carlo , Gour Gilad
Published: November 2023

Thermodynamics plays an important role both in the foundations of physics and in technological applications. An operational perspective adopted in recent years is to formulate it as a quantum resource theory. At the core of this theory is the interconversion between athermality states, i.e. states out of thermal equilibrium. Here, we solve the question of how athermality can be used to heat and cool other quantum systems that are initially at thermal equilibrium. We then show that the convertibility between quasi-classical resources (resources that do not exhibit coherence between different energy eigenstates) is fully characterized by their ability to cool and heat qubits, i.e. by two of the most fundamental thermodynamical tasks on the simplest quantum systems.
Cooperative behaviors in spatial multi-game based on Hawkes processes
Authors: Yan Shiqi , Luo Chao
Published: November 2023

As for collective behaviors in reality, the occurrence of similar events in group is not independent, in which the occurrence historical events, such as frequencies, interval time, etc, would have an incentive effect on their recurrence probability. In spired by this, Hawkes process is first introduced into evolutionary game model. Different from the existing works, the game behaviors in a networked group change from certainty to probabilistic behaviors affected by historical events. Specifically, an incentive effect will occur with the occurrence of game behaviors as well as decay with the lapse of time. Based on the above probabilistic game mechanism, a multi-game model is proposed, where players are assumed to be emotional for their owned resources. In general, the results of game behaviors would determine the allocation of resources, and the owned quantities of resources would affect the emotion of players. As a feedback loop, it finally affects the game strategy of players. In experiments, the mutual effect of limited resources and game strategy based on probabilistic game mechanism is quantitatively studied. Meanwhile, a phase transition of cooperative behaviors is explored, which is mainly arising from the probabilistic game processes and the evolving emotions of players.
Multilayer graphene and black phosphorus thin-film frequency doublers using direct-current bias
Authors: Mao Mengxin , Fang Yong , Wei Haoxing , Huang Zunkai , Xu Haizhou
Published: November 2023

Multilayer graphene and black phosphorus films exhibit strong nonlinearity under voltage modulation. In this paper, according to the nonlinear characteristics of graphene and black phosphorus, the frequency doubling characteristics of graphene and black phosphorus are introduced, and the nonlinear SDD model of graphene is established in EDA, and the simulation results are basically consistent with the measured results. Under the regulation of DC bias voltage, the second harmonic output power of both graphene frequency doubler and black phosphorus frequency doubler is larger than their third harmonic output power when the operating frequency is 800–1100 MHz. The experimental results show that the minimum conversion loss of the black phosphorus multiplier is 24.22 dB when the input voltage is 0.9 V and the input power is 12 dBm, and the minimum conversion loss of the graphene multiplier is 32.15 dB when the input voltage is 1.6 V. The experimental results show that the conversion loss of the black phosphorus multiplier is better than that of the graphene multiplier, and the conversion efficiency is higher.
Dye-sensitized solar cells containing photoelectrodes with TiO2 grids
Authors: Chiang Yu-Chih , Lee Chia-Rong , Huang Chia-Yi
Published: November 2023

A 90-nm-thick TiO2 grid is created through photolithography, sputtering and lift-off process in this study. A nanoporous film is deposited on the TiO2 grid. The grid induces a protrusive structure in the nanoporous film. Experimental results demonstrate that introducing the TiO2 grid into a dye-sensitized solar cell increases its power conversion efficiency by 25% compared to a dye-sensitized solar cell lacking a TiO2 grid. Consequently, the TiO2 grid proves beneficial in augmenting the power conversion efficiency of the dye-sensitized solar cell. The increased power conversion efficiency of the dye-sensitized solar cell containing the TiO2 grid is attributed to the large surface area and directional electron transport channels of the protrusive structure. The TiO2 grid offers advantages such as simple fabrication, cost-effective production and improved power conversion efficiency.
Gate electrode stacked source/drain SON trench MOSFET for biosensing application
Authors: Mishra Sikha , Mohanty Soumya S , Mishra Guru Prasad
Published: November 2023

This work inspects a dielectrically modulated (DM) stacked source/drain SiGe dual-metal trench gate silicon on nothing (SON) metal–oxide–semiconductor field-effect transistor (SiGe-DMTG SON MOSFET) biosensor to enhance the sensing capability of the device. A nano-cavity is implanted in the either side of gate area for immobilization of biomolecules which can modulate the gate capacitance and dielectric constant of the nanocavity area. Thus the device undergoes a threshold voltage shift which has a great impact on device sensitivity. So SiGe-DMTG SON MOSFET biosensor is proposed to identify the sensing performance of various analytes like Uricase (k = 1.54), Streptavidin (k = 2.1), Biotin (k = 2.63), 3-aminopropyltriethoxysilane (APTES) (k = 3.57) and protein (k = 8) using DM technique. The electrostatic properties of the neutral biomolecules such as electrostatic potential, electric field, On current, switching ratio, threshold voltage, On current sensitivity, threshold voltage sensitivity, and subthreshold performance of SiGe-DMTG SON MOSFET biosensor have been evaluated using 2D ATLAS device simulator. Further, the parasitic capacitances of the proposed biosensor has been investigated for different biomolecules in the nano-cavity region in order to observe the sensing performance of the device. From the result analysis it has been observed that for protein (k = 8), the proposed SiGe-DMTG SON MOSFET biosensor offers a threshold voltage sensitivity of 0.581 and On current sensitivity of 1.765. Apart from this, protein (k = 8) offers a strong threshold voltage shift of 104.8 mV with respect to k = 1 shows best suited for biosensing application.
Normal form for bifurcations of ion acoustic traveling waves in positive-negative ion species plasmas
Authors: Alinejad H , Poria S
Published: November 2023

The normal form for saddle-node and transcritical bifurcation of nonlinear ion-acoustic waves is derived in complex negative-positive plasmas. The physical parameters of four different kinds of multi-ion plasmas which mainly comprise of positive ions (i.e. Xe+ and Ar+) with a minority constituent of negative ions (i.e.

SF

6

−

and F
−), inspired from the experimental studies, are examined on the types of bifurcations and nonlinear wave profiles. We find that such multi-ion plasmas admit transcritical bifurcation preceding the onset of saddle-node bifurcation. The fractional concentration of negative ions controls the dynamics of ion acoustic traveling waves and causes the appearance of solitary structures and supernonlinear periodic waves. When two nonlinear waves disappear via a saddle-node bifurcation on increasing the negative ion concentration, a nonlinear periodic wave is formed. Further, we reveal critical values of ion density marking the transition between nonlinear modes. Such critical points that can be detected analytically give rise to the propagation of new solitary structures. The results obtained here not only limited to laboratory plasmas, but can also be applied to explain wave excitations in space plasma environments.
The application of differential constraint method for the solution of non-homogeneous generalized Riemann problem
Authors: Gaurav  , Singh L P , Pradeep
Published: November 2023

This paper reports the solution to the Non-homogeneous Riemann problem by applying the approach of differential constraint for the one-dimensional (1 − D) generalized Chaplygin gas equations with non-constant initial data. Here we take source term as a Coulomb type constant frictional term. We reduced the governing non-homogeneous model into a homogeneous one by introducing a new velocity variable. By virtue of this advantage of frictional type source term, we would easily determine the solution of reformulated homogeneous governing model. We have computed the differential constraint and its consistency conditions for the specified model. Moreover, we have derived here the compatibility condition between the governing model and the differential constraints. The solutions to generalized Riemann problem for the 1 − D Euler’s equation of governing gas model are obtained as well as for the smooth and non-constant initial conditions the comprehensive overview of the solutions is studied.
Temporal evolution and spectral characteristics of dual field in a double-pumped microcavity
Authors: Xu Xin , Ye Huichun , Jin Xueying , Chen Dong , Xia Haojie
Published: November 2023

To generate dual combs for various precision measurements, the temporal evolution and spectral characteristics of dual fields in a double-pumped microcavity are investigated. Results show that by using dual orthogonally polarized pumps, the dual fields can be controlled by regulating the two detunings. The coexistence of solitons and Turing patterns, which is equivalent to dual-frequency combs with a large repetition frequency difference, can be excited. Two positive detuning parameters are similar, and two soliton pulses with identical free spectral ranges and different intensities are formed. Moreover, two weaker positive detunings are beneficial for the dual Turing patterns. Furthermore, breathers and multiple pulses can be excited under special conditions. The effects of dispersion and pump intensity on the dual fields are also studied. Dual combs exist in an anomalous dispersion regime and the strong negative dispersion only leads to DC fields. For the pump intensity, with the increase of pumping power, one field experiences breathers and variable multi-pulse in sequence while the other field maintains Turing patterns. The results of this study provide a new approach to excite dual-frequency combs by using a single microcavity.