bluuebunny/crossref_metadata_2025 huggingface dataset:
Atlantoaxial Instability due to Os Odontoideum in a Child with Christianson Syndrome
Authors: Güven Nezaket Ezgi , Uçmak Hacer , İlter Uçar Çiğdem , Havan Merve , Yıldırım Miraç , Teber Serap , Kendirli Tanıl
Published: March 2024

Introduction: Christianson syndrome is a rare neurodevelopmental disorder associated with mutations in the SLC9A6 gene located on the chromosome X. It is characterized by intellectual disability, developmental delay, speech and language impairments, dysmorphic features, seizures, ataxia, and neurobehavioral problems. Case Presentation: A 5-year-old boy was presented with respiratory failure and then progressive muscle weakness in all four extremities. He manifested acquired microcephaly, intellectual disability, global developmental delay, distinct dysmorphic facial features, seizures, spastic tetraparesis, truncal hypotonia, speech impairment, failure to thrive, malnutrition, recurrent lung infections, self-mutilation, primary hyperparathyroidism, medullary nephrocalcinosis, and atlantoaxial instability due to os odontoideum. Brain magnetic resonance imaging revealed atlantoaxial instability due to os odontoideum, a narrow foramen magnum, myelopathy due to spinal cord compression, and cerebral and cerebellar atrophy. Discussion: This report highlights a significant contribution by introducing a child with Christianson syndrome describing atlantoaxial instability due to os odontoideum, a previously undocumented phenomenon. This report suggests a potential link between Christianson syndrome and atlantoaxial instability. In children with Christianson syndrome experiencing increased muscle weakness in all extremities during follow-up, consideration of underlying myelopathy due to os odontoideum is advised.
Acupuncture for Tinnitus: A Scoping Review of Clinical Studies
Authors: Lee Keun Hee , Kim Min Hee , Kim Jaeho , Nam Hae Jeong
Published: March 2024

Background: Acupuncture treatment for tinnitus has received attention owing to its potential as an alternative to conventional treatment modalities. We conducted a scoping review to identify detailed information on acupuncture treatment methods used in clinical studies and to provide useful information for practitioners, patients, and researchers. Methods: MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), Embase, Oriental Medicine Advanced Searching Integrated System (OASIS), Korean Research Information Sharing Service (RISS), DataBase Periodical Information Academic (DBPIA), and the China National Knowledge Infrastructure (CNKI) were searched from their inception to December 2023. This review included single-arm trials, open-label randomized controlled trials (RCTs), and double-blind RCTs using needle-type acupuncture to treat tinnitus in English, Chinese, and Korean. We investigated basic and detailed information on the acupuncture treatment methods, assessment methods, and study outcomes. Network analysis was also conducted to evaluate the centrality between acupoints in the double-blind RCTs. Results: We included 106 articles. There were 11 single-arm trials, 90 open-label RCTs, and 5 double-blind RCTs. Most (89.6%) of these studies were conducted in China. Manual acupuncture was the most common type of acupuncture in treatment group. A total of 119 acupuncture points were used 1,138 times. The most frequently used acupoints were local points around the ear (TE17, GB2, SI19, and TE21). Both local and distant acupoints were used simultaneously in these studies. The treatment duration of 20–39 days, 10 to 19 sessions of treatment, the mean acupuncture duration of 30 min, needle diameter of 0.30 mm × 40 mm, and needling depth over 30 mm and less than 50 mm were confirmed as the most common. Conclusion: These study outcomes will enable future acupuncture studies on tinnitus to perform more effective and standardized acupuncture treatments in selecting acupoints and procedures. Furthermore, the study has implications for informing clinicians and students about more impactful acupuncture strategies for addressing tinnitus.
First in vivo Experiment with PulmValve Endobronchial Valve: Feasibility, Efficiency, and Safety
Authors: Liu Jingwei , Chen Difei , Yu Yanhui , Deng Yu , Lu Ruijin , Zhang Jing , Li Shiyue
Published: March 2024

Introduction: Endoscopic lung volume reduction with endobronchial valves has been widely recognized for treating hyperinflation in advanced chronic obstructive pulmonary disease and emphysema patients. The main challenges include the technical complexity of upper lobe implantation and the number of endobronchial valves required. These issues might be addressed by placing larger diameter valves in the lobar bronchus. This study evaluated the feasibility, efficiency, and safety of the new valve PulmValve (model PV-13) in porcine models. Methods: Six PV-13 valves were bronchoscopically implanted into the caudal lobe bronchus of six healthy pigs. The procedure time, valve deployment, and removability were recorded. Follow-up examinations included blood tests, chest CT scans, and bronchoscopy at 30 min, 14 days, 28 days, and 84 days post-procedure, with necropsy and pathological evaluations after the final follow-up examination. Results: The successful in vivo deployment and removal of PV-13 valves was established, with a median procedure time of 6.5 min. The distal lung volume reduction was evident at 30 min post-operation and was persistently monitored on day 84. No migration or malfunction of any PV-13 valves was detected, but a mild angle deviation was found in 3 cases. Coughing was observed in four pigs within the first 7 days and localized granulation tissue was observed in all pigs. No cases of pneumothorax, diffuse pneumonia, or hemoptysis were detected. Conclusions: In this study, we report the successful implantation and removal of a new valve PulmValve in a short operation time. Complete lobar atelectasis was induced without device migration, malfunction, or severe complications. Further studies are warranted to evaluate the long-term, sustained effects and potential benefits in human patients.
In vivo Assessment of a Manual Single Lumen Alternating Micro-Batch Hemodiafiltration System
Authors: Lanker Sabrina L. , Pino Christopher J. , Humes H. David , Chawla Lakhmir , Johnston Kimberly A.
Published: March 2024

Introduction: The manual single lumen alternating micro-batch hemodiafiltration (mSLAMB) system is a closed-loop dialysis system designed to provide kidney support in emergency situations (e.g., fluid overload, hyperkalemia, acidemia). If done repeatedly in small batches and at high flow rates, this system was found to achieve clearance levels comparable to traditional renal replacement therapy. Methods: Using a porcine model, uremic toxins and exogenous fluorescent tracer concentrations were successfully lowered within just 1 h of treatment. Results: With a maximal dialysate flow, mSLAMB can achieve decreases in serum potassium concentration of >0.5 mmol/L/h. With the mSLAMB hemodiafiltration system, micro-batch processing was also successful in removing up to 250 mL of ultrafiltrate in 8 cycles. Conclusion: This process could create a better fluid balance allowing for administering therapeutic fluids such as sodium bicarbonate in the clinic. Electrolyte imbalance and volume overload remain severe life-threatening emergencies in low resource settings; therefore, mSLAMB should be explored further due to its modest vascular access requirements, low cost, and ability to be performed without electricity or batteries.
Level of Acceptability of Computer-Assisted Assessment (CAA) and Student’s Academic Performance in Key Stage 2 of Ilalim Elementary School for The School Year 2022-2023
Authors: Agoja, Jr. Jesse S. , Albino Michael G.
Published: March 2024

In this research study, the researcher aimed to determine the level of acceptability of computer-assisted assessment and learners’ academic performance of 127 Key Stage 2 Learners of Ilalim Elementary School for the School Year 2022-2023. A descriptive survey instrument was used to determine the level of acceptability adapted from the computer-based assessment acceptance model (CBAAM) and was modified by the researcher.
Data revealed that the use of computer-assisted assessment of the Key Stage 2 learners was Moderately Acceptable with a mean of 4.01, indicating that the application purposively used it to improve their knowledge and skills. The learners gained an Outstanding academic performance as reflected in their general weighted average from the four grading periods. Significant differences were found in the level of acceptability of the use of computer-assisted assessment on the profile variables of the learner-respondents. Moreover, the results showed a positive correlation between the level of acceptability of the use of computer-assisted assessment on the learner’s academic performance.
Based on the gathered data from the survey, computer-assisted assessment provides the learners with a positive experience when using the application through its friendly user interface. Teachers may continue to use the computer-assisted assessment application to motivate their learners to increase their engagement in learning their subject. It is recommended that teachers may further enhance the delivery of questions in the CAA application to improve learners’ academic performance in the future.
Examining the Impact of Layperson Rescuer Gender on the Receipt of Bystander CPR for Women in Cardiac Arrest
Authors: Shelton Shelby K. , Rice John D. , Knoepke Christopher E. , Matlock Daniel D. , Havranek Edward P. , Daugherty Stacie L. , Perman Sarah M.
Published: March 2024

BACKGROUND:

Women who suffer a witnessed out-of-hospital cardiac arrest receive bystander cardiopulmonary resuscitation (CPR) less often than men. To understand this phenomenon, we queried whether there are differences in deterrents to providing CPR based on the rescuer’s gender.

METHODS:

Participants were surveyed using a national crowdsourcing platform. Participants ranked the following 5 previously identified themes as reasons: rescuers are afraid to injure or hurt women; rescuers might have a misconception that women do not suffer cardiac arrest; rescuers are afraid to be accused of sexual assault or sexual harassment; rescuers have a fear of touching women or that their touch might be inappropriate; and rescuers think that women are faking it or being overdramatic. Participants were adult US residents able to correctly define CPR. Participants ranked the themes if the rescuer was gender unidentified, a man, and a woman, in variable order.

RESULTS:

In November 2018, 520 surveys were completed. The respondents identified as 42.3% women, 74.2% White, 10.4% Black, and 6.7% Hispanic. Approximately half (48.1%) of the cohort knew how to perform CPR, but only 7.9% had ever performed CPR. When the rescuer was identified as a man, survey participants ranked fear of sexual assault or sexual harassment and fear of touching women or that the touch might be inappropriate as the top reasons (36.2% and 34.0% of responses, respectively). Conversely, when the rescuer was identified as a woman, survey respondents reported fear of hurting or injuring as the top reason (41.2%).

CONCLUSIONS:

Public perceptions as to why women receive less bystander CPR than men were different based on the gender of the rescuer. Participants reported that men rescuers would potentially be hindered by fears of accusations of sexual assault/harassment or inappropriate touch, while women rescuers would be deterred due to fears of causing physical injury.
Associations of Alcohol Consumption With Left Atrial Morphology and Function in a Population at High Cardiovascular Risk
Authors: Alam Aniqa B. , Toledo‐Atucha Estefania , Romaguera Dora , Alonso‐Gómez Angel M. , Martínez‐Gonzalez Miguel A. , Tojal‐Sierra Lucas , Mora Marta Noris , Mas‐Llado Caterina , Li Linzi , Gonzalez‐Casanova Ines , Salas‐Salvadó Jordi , Fitó Montserrat , Alonso Alvaro
Published: March 2024

Background

Excessive alcohol consumption has been associated with increased risk of atrial fibrillation, although the underlying mechanisms remain unclear. An enlarged left atrium and impaired left atrial function may lead to atrial fibrillation. The association of alcohol consumption with structural and functional left atrial measures, however, has received limited attention.

Methods and Results

We studied 503 participants from the PREDIMED‐Plus (Prevención con Dieta Mediterránea) trial, a randomized trial testing intensive weight loss intervention with an energy‐reduced Mediterranean diet and physical activity promotion in preventing cardiovascular disease in adults with metabolic syndrome. Participants underwent transthoracic echocardiography at baseline, year 3, and year 5 of the study. Outcomes of interest included volume index and reservoir, conduit, and contractile strains of the left atrium. Alcohol consumption was calculated through food frequency questionnaires and presented as drinks consumed per day. Multiple linear regression and mixed models estimated the association of alcohol consumption with left atrial measurements at baseline and through follow‐up. Cross‐sectionally, higher alcohol consumption (per 1 drink/day increases) was associated with larger left atrial volume (0.65 mL/m
2
[95% CI, 0.18–1.11]) and lower left atrial reservoir and contractile strain (−0.44% [95% CI, −0.87 to −0.01]; and −0.44% [95% CI, −0.75 to −0.14]). Baseline alcohol consumption was not associated with changes in left atrial measurements, but increases in alcohol consumption (per 1 drink/day increase) during follow‐up were associated with left atrial enlargement (0.71 mL/m
2
[95% CI, 0.17–1.26]).

Conclusions

In a population at high cardiovascular risk, increased alcohol consumption was associated with left atrial enlargement and worsening atrial function.

Registration

URL:
http://www.controlled‐trials.com
; Unique identifier: ISRCTN89898870.
Heart Rate Variability, Deceleration Capacity of Heart Rate, and Death: A Veteran Twins Study
Authors: Huang Minxuan , Shah Amit J. , Lampert Rachel , Bliwise Donald L. , Johnson Dayna A. , Clifford Gari D. , Sloan Richard , Goldberg Jack , Ko Yi‐An , Da Poian Giulia , Perez‐Alday Erick A. , Almuwaqqat Zakaria , Shah Anish , Garcia Mariana , Young An , Moazzami Kasra , Bremner J. Douglas , Vaccarino Viola
Published: March 2024

Background

Autonomic function can be measured noninvasively using heart rate variability (HRV), which indexes overall sympathovagal balance. Deceleration capacity (DC) of heart rate is a more specific metric of vagal modulation. Higher values of these measures have been associated with reduced mortality risk primarily in patients with cardiovascular disease, but their significance in community samples is less clear.

Methods and Results

This prospective twin study followed 501 members from the VET (Vietnam Era Twin) registry. At baseline, frequency domain HRV and DC were measured from 24‐hour Holter ECGs. During an average 12‐year follow‐up, all‐cause death was assessed via the National Death Index. Multivariable Cox frailty models with random effect for twin pair were used to examine the hazard ratios of death per 1‐SD increase in log‐transformed autonomic metrics. Both in the overall sample and comparing twins within pairs, higher values of low‐frequency HRV and DC were significantly associated with lower hazards of all‐cause death. In within‐pair analysis, after adjusting for baseline factors, there was a 22% and 27% lower hazard of death per 1‐SD increment in low‐frequency HRV and DC, respectively. Higher low‐frequency HRV and DC, measured during both daytime and nighttime, were associated with decreased hazard of death, but daytime measures showed numerically stronger associations. Results did not substantially vary by zygosity.

Conclusions

Autonomic inflexibility, and especially vagal withdrawal, are important mechanistic pathways of general mortality risk, independent of familial and genetic factors.
Deviation From Personalized Blood Pressure Targets Correlates With Worse Outcome After Successful Recanalization
Authors: Zhang Zhe , Pu Yuehua , Yu Lei , Bai Haiwei , Duan Wanying , Liu Xin , Nie Ximing , Wen Zhixuan , Zheng Lina , Hu Xiao , Leng Xinyi , Pan Yuesong , Petersen Nils H. , Liu Liping
Published: March 2024

Background

Personalized blood pressure (BP) management for patients with acute ischemic stroke after successful endovascular thrombectomy lacks evidence. We aimed to investigate whether the deviation of BP from cerebral autoregulation limits is associated with worse outcomes.

Methods and Results

We determined autoregulation by measuring mean velocity index and calculated the percentage of time and the burden (defined as the time‐BP area) with BP outside the autoregulatory limits of each subject within 48 hours after endovascular thrombectomy. In total, 91 patients with large vessel occlusion stroke who had achieved successful recanalization were prospectively enrolled between May 2020 and February 2022. The burden with BP outside the autoregulatory limits was associated with poor outcome (modified Rankin Scale score 3–6) at 90 days (adjusted odds ratio, 1.28 [95% CI, 1.03–1.59]). The percentage of time with BP out of the autoregulatory limits was correlated with early neurological deterioration (National Institute of Health Stroke Scale scores increased ≥2 at 7 days) (adjusted odds ratio, 1.38 [95% CI, 1.04–1.83]). The burden of BP that decreased below the autoregulatory lower limit was associated with significant infarct growth (volume of infarct growth >11.6 mL) at 7 days (adjusted odds ratio, 1.21 [95% CI, 1.01–1.44]). The percentage of time that BP exceeded the autoregulatory upper limit was associated with symptomatic intracranial hemorrhage within 48 hours (adjusted odds ratio, 1.55 [95% CI, 1.02–2.34]).

Conclusions

Both the percentage of time and the burden of BP that deviates from the autoregulation‐preserved range are associated with unfavorable clinical outcomes. This study highlights the potential benefits of autoregulation‐guided BP management strategy after successful recanalization.
Holarctic Lineages Cannot Inform Diversity and Evolution in the Neotropics – the barklice family Psocidae as a case study
Authors: Sarria-Rodríguez Valentina , Gonzalez-Obando Ranulfo , Rivera-Franco Nelson , Cardenas-Henao Heiber , Román-Palacios Cristian
Published: March 2024

Despite tropical species comprising nearly 60% of Psocidae species, previous studies examining the Psocidae phylogeny have undersampled tropical diversity (<40% species in trees). Here we discuss the systematics of the Psocidae based on the most comprehensive species-level sampling of the Psocidae. We infer the phylogenetic position of 43 previously unsampled Neotropical species in the Psocidae phylogeny. We find that Neotropical psocids are generally not closely related to morphologically similar taxa in the Holarctic region. Consequently, the monophyletic status for the major groups within Psocidae (subfamilies and tribes) is recovered only when Holarctic groups are sampled (7–10 of 11 higher-level groups are monophyletic) but violated when Neotropical species are also sampled in the tree (1 of 11 higher-level groups are monophyletic). Our study pinpoints at the downfalls of simply extending taxonomic knowledge from lineages of a certain area (i.e. Holarctic) to inform diversity and evolution of lineages in other regions (i.e. Neotropics).
Impact and adoption of feed technologies at Nharira-Lancashire Dairy Scheme
Authors: Washaya S. , Masunda B. , Ngongoni N.T.
Published: March 2024

The objective of this study was to investigate the impact and adoption of nutrition technologies and their effect on milk production at the Nharira-Lancashire dairy scheme. Sixty households (30 from each scheme) were randomly selected and interviewed by use of a semi-structured questionnaire. Fisher’s exact and Monte Carlo tests were carried out to determine the association between farmer experience and feed technology. Logistic regression was used to rank farmers’ awareness and adoption of feed technologies. The results indicated that farmers have been exposed to at least five new feed technologies and adoption is influenced by education status, sex, age and gender of household head (P < 0.05). Feed technology adoption was in the order: silage 70.83% > sunflower cake 41.66% > legume reinforcement 27.1% > legume trees 16.66% > napier fodder 8.33% > urea treatment 4.17%. Milk yield was affected by month and year (P < 0.05). The impact of adoption was below anticipation, as indicated by lack of economic surpluses. A cost-benefit analysis needs to be carried out for all feed technologies within the study area to streamline viable options.
Law of the Sea Dispute Settlement in the Eastern Mediterranean with Particular Reference to the Delimitation of Palestine’s Maritime Boundaries: Negotiation, Conciliation, Arbitration, or Adjudication?
Authors: Qafisheh Mutaz M.
Published: March 2024

Palestine currently holds contractual relations with 167 States under the UN Convention on the Law of the Sea. unclos’s dispute settlement mechanisms might vary depending on the process States have opted for. In order to pick a preferred mechanism, a State Party should deposit a declaration with the UN Secretary-General. As it did not file any such declaration, Palestine is deemed to have accepted arbitration by default. However, Palestine can still deposit a declaration to choose other procedures and therefore open the possibility to resort to the International Court of Justice, the International Tribunal for the Law of the Sea, or a special arbitration. Yet, the neighboring States have different approaches. While Egypt has cast opposition to arbitration regarding boundary delimitation, Israel is not a Party to unclos and does not recognize its settlement mechanisms. How can disputes be resolved? Would conciliation work? What are exit channels? This article answers such questions.
A new species of Passiflora (Passifloraceae, subgenus Passiflora) in the flora of Colombia discovered in uncharted Andean territory
Authors: ARRIGUI-TORRES EDWIN , OCAMPO JOHN A. , ROSERO-TORO JEISON HERLEY
Published: March 2024

A new species of Passiflora belonging to the subgenus Passiflora (supersection Stipulata, section Kermesinae) is described and illustrated from living material and herbarium specimens. Passiflora pitalensis is similar to P. lehmannii, and it can be recognized primarily by its petiole green, leaves with broader lobes, peduncle green, bract lanceolate, corona filaments in 5 series with outer filaments in 2 series, fruit ovoid, and seed margin dentate. This species is rare and endemic to Colombia in the Andean region at elevations ranging from 1,749–2,027 m and should be considered Endangered (EN) due to its restricted occurrence with a small population size of no more than 90 individuals.
The genus Pristaulacus Kieffer, 1900 (Hymenoptera: Aulacidae) in Vietnam and Northeastern Laos with descriptions of ten new species
Authors: PHAM NHI THI , LONG KHUAT DANG , JENNINGS JOHN T , DZUONG NGUYEN VAN , MAI PHAM QUYNH , TURRISI GIUSEPPE FABRIZIO
Published: March 2024

The genus Pristaulacus Kieffer (Hymenoptera, Aulacidae) from Vietnam is revised with eight new species, namely P. alius Long, sp. nov., P. bicoloratus Long & Jennings, sp. nov., P. chumomrayi Long & Turrisi, sp. nov., P. diffusus Long & Turrisi, sp. nov. (including Northeastern Laos), P. mellosus Turrisi, Long & Pham, sp. nov. (including Northeastern Laos), P. phiaoacus Long, sp. nov., P. simulatus Long, Jennings & Turrisi, sp. nov. (including Northeastern Laos), P. tranganicus Long & Pham, sp. nov. are described and illustrated, and one species, P. asiaticus Turrisi & Smith, 2011 is recorded for the first time from Vietnam. In addition, two new species from Northeastern Laos (Houaphanh province) are described, P. mathematicus Turrisi & Jennings, sp. nov., and P. pilosellus Turrisi & Long, sp. nov. A key to Vietnamese Pristaulacus species is provided.
Difference between Upshear- and Downshear-Propagating Waves Associated with the Development of Squall Lines
Authors: Yang Hongpei , Du Yu
Published: March 2024

During the development of squall lines, low-frequency gravity waves exhibit contrasting behaviors behind and ahead of the system, corresponding to its low-level upshear and downshear sides, respectively. This study employed idealized numerical simulations to investigate how low-level shear and tilted convective heating influence waves during two distinct stages of squall-line evolution. In the initial stage, low-level shear speeds up upshear waves, while it has contrasting effects on the amplitudes of different wave modes, distinguishing it from the Doppler effect. Downshear deep tropospheric downdraft (n = 1 wave) exhibits larger amplitudes, resulting in strengthened low-level inflow and upper-level outflow. However, n = 2 wave with low-level ascent and high-level descent has higher amplitude upshear and exhibits a higher altitude of peak w values downshear, leading to the development of a more extensive upshear low-level cloud deck and a higher altitude of downshear cloud deck. In the mature stage, as the convective updraft greatly tilts rearward (upshear), stronger n = 1 waves occur behind the system, while downshear-propagating n = 2 waves exhibit larger amplitudes. These varying wave behaviors subsequently contribute to the storm-relative circulation pattern. Ahead of the squall line, stronger n = 2 waves and weaker n = 1 waves produce intense outflow concentrated at higher altitudes, along with moderate midlevel inflow and weak low-level inflow. Conversely, behind the system, the remarkable high pressure in the upper troposphere and wake low are attributed to more intense n = 1 waves. Additionally, the cloud anvil features greater width and depth rearward and is situated at higher altitudes ahead of the system due to the joint effects of n = 1 and n = 2 waves.

Significance Statement

Squall lines are a significant source of high-impact weather events, and their development has been partially explained through linear wave dynamics. While the recurrent generation of waves during squall-line evolution has been found, the differentiation of wave behavior behind and ahead of the system, as well as its implications for storm circulation, has remained unclear. This study employs idealized simulations to reveal that during different stages of convection, low-level shear and the tilting of convective heating exert contrasting effects on wave behaviors. Moreover, various wave modes exhibit distinct responses to specific factors, and their combined effect elucidates the structural discrepancies observed both rearward and forward of the convective updraft. These findings could allow a step toward a better understanding of the intricate interaction between waves and convections.
Subseasonal Potential Predictability of Horizontal Water Vapor Transport and Precipitation Extremes in the North Pacific
Authors: Higgins Timothy B. , Subramanian Aneesh C. , Chapman Will E. , Lavers David A. , Winters Andrew C.
Published: March 2024

Accurate forecasts of weather conditions have the potential to mitigate the social and economic damages they cause. To make informed decisions based on forecasts, it is important to determine the extent to which they could be skillful. This study focuses on subseasonal forecasts out to a lead time of four weeks. We examine the differences between the potential predictability, which is computed under the assumption of a “perfect model,” of integrated vapor transport (IVT) and precipitation under extreme conditions in subseasonal forecasts across the northeast Pacific. Our results demonstrate significant forecast skill of extreme IVT and precipitation events (exceeding the 90th percentile) into week 4 for specific areas, particularly when anomalously wet conditions are observed in the true model state. This forecast skill during weeks 3 and 4 is closely associated with a zonal extension of the North Pacific jet. These findings of the source of skillful subseasonal forecasts over the U.S. West Coast could have implications for water management in these regions susceptible to drought and flooding extremes. Additionally, they may offer valuable insights for governments and industries on the U.S. West Coast seeking to make informed decisions based on extended weather prediction.

Significance Statement

The purpose of this study is to understand the differences between the ability to predict high amounts of the transport of water vapor and precipitation over the North Pacific 3 and 4 weeks into the future. The results indicate that differences do exist in a region that is relevant to precipitation on the U.S. West Coast. To physically explain why differences in predictability exist, the relationship between weekly extremes of the extension of the jet stream, IVT, and precipitation over the North Pacific is explored. These findings may impact decisions relevant to water management on the U.S. West Coast susceptible to drought and flooding extremes.
Impact of the Kidney Allocation Revision on Access to Kidney Transplantation and Outcomes in the United States
Authors: Akinyemi Oluwasegun A. , Weldeslase Terhas A. , Odusanya Eunice A. , Hughes Kakra , Cornwell Edward E. , Callender Clive O.
Published: March 2024

Background

The 2014 Kidney Allocation System (KAS) revision aimed to enhance equity in organ allocation and improve patient outcomes. This study assesses the impacts of the KAS revision on renal transplantation demographics and outcomes in the United States.

Methods

We conducted a retrospective study utilizing the Organ Procurement and Transplantation Network/Scientific Registry of Transplant Recipients (OPTN/SRTR) database from 1998 to 2022. We compared recipient and donor characteristics, and outcomes (graft failure and recipient survival) pre- and post-KAS revision.

Results

Post-KAS, recipients were significantly older (53 vs 48, P < .001) with an increase in Medicaid beneficiaries (7.3% vs 5.5%, P < .001). Despite increased graft survival, HR = .91 (95% CI 0.80-.92, P < .001), overall recipient survival decreased, HR = 1.06 (95% CI 1.04-1.09, P < .001). KAS revision led to greater racial diversity among recipients and donors, enhancing equity in organ allocation. However, disparities persist in graft failure rates and recipient survival across racial groups.

Discussion

The 2014 Kidney Allocation System revision has led to important changes in the renal transplantation landscape. While progress has been made towards increasing racial equity in organ allocation, further refinements are needed to address ongoing disparities. Recognizing the changing patient profiles and socio-economic factors will be crucial in shaping future policy modifications.
Type of Prior Operation Does Not Predict Surgical Intervention for Small Bowel Obstruction
Authors: Van Horn Alexandra L. , Soult Alexa P. , Sternick Molly E. , Sturm Emily L. , Britt Rebecca C.
Published: March 2024

Background: Patients with prior abdominal surgeries are at higher risk for intra-abdominal adhesive tissue formation and subsequently higher risk for small bowel obstruction (SBO).

Purpose: In this study, we investigated whether surgical intervention for SBO was more likely following specific types of abdominal surgeries.

Research Design: With retrospective chart review, we pooled data from 799 patients, ages 18 to 89, admitted with SBO between 2012 and 2019. Patients were evaluated based on whether they underwent surgery or were managed conservatively. They were further compared with regard to past surgical history by way of type of abdominal surgery (or surgeries) undergone prior to admission.

Results: Of the 799 patients admitted for SBO, 206 underwent surgical intervention while 593 were managed nonoperatively. There was no significant difference in number of prior surgeries (2.07 ± 1.56 vs 2.36 ± 2.11,  P = .07) or in number of comorbidities (2.39 ± 1.97 vs 2.65 ± 1.93,  P = .09) for surgical vs non-surgical intervention. Additionally, of the operations evaluated, no specific type of abdominal surgery predicted need for surgical intervention in the setting of SBO. However, for both surgical and non-surgical intervention following SBO, pelvic surgery was the most common type of prior abdominal surgery (45% vs 43%). There are significantly more female pelvic surgeries in both the operative (91.4% vs 8.6%,  P < .0001) and nonoperative groups (89.9% vs 10.2%,  P < .0001).

Conclusion: Ultimately, no specific type of prior operation predicted the need for surgical intervention in the setting of SBO.
A Playstation Mentality to Killing? Adverse Psychological Consequences in Drone Pilots and the Stigmatization thereof in the Military
Authors: Molenkamp Ayla , Weerdesteijn Maartje , Smeulers Alette
Published: March 2024

Since the start of the 21st century, drones are increasingly used for military purposes. There have been concerns that the work of drone pilots resembles a video game and it has been argued that drone pilots are less likely to develop mental health problems than other service members. Such an assumption could increase stigmatization but empirical research is lacking. For this explorative study, 11 respondents were interviewed. They were purposefully sampled from the United States, the Netherlands, and Israel because of their insight into the working environment of drone pilots. These respondents included scholars, a therapist, and military personnel. They suggested that drone pilots do face mental health problems because of their work and that due to their distance to the battlefield, stigmatization of these problems is more likely. These findings, however, are nuanced by differences across countries and units.
Leadership in a Crisis: A Social Network Perspective on Leader Brokerage Strategy, Intra-Organizational Communication Patterns, and Business Recovery
Authors: Li Ning , Zheng Xiaoming , Ni Dan , Kirkman Bradley L. , Zhang Mengyi , Xu Mingze , Liu Chenlin
Published: March 2024

Catastrophic events can significantly disrupt businesses and, as a result, understanding how organizations adapt to a crisis is critical. Undeniably, leaders often play a crucial role in times of great uncertainty. Yet, it is unclear exactly how leaders can effectively guide organizations through a crisis. Extending theories of network brokerage and organizational adaptation research, we posit that compared to leaders creating structural holes in intra-organizational communication networks, those leaders bridging structural holes can build more effective communication networks with greater cohesion and higher efficiency. In turn, greater cohesion and higher efficiency subsequently drive organizational adaptation and business recovery in a multi-unit enterprise during the early outbreak of COVID-19. Our hypotheses are supported using multi-wave network surveys in 111 chain restaurants with over 3,000 employees. We demonstrate that, during a crisis, leaders can serve as a key architect to shape communication patterns to facilitate organizational adaptation to crises and drive business recovery with faster customer growth and continually decreasing personnel costs.
Beyond Borders: Understanding Afghanistan's International Migration Dynamics and Global Implications
Authors: Hamid Shapoor
Published: March 2024

Afghanistan, a landlocked nation with a turbulent history of conflict and natural disasters, has experienced the evolution of migration as a strategic response to a range of challenges. Over time, Afghans have developed a resilient transnational network, using mobility as a way to cope and as a proactive strategy. This article explores the dynamics of Afghan migration, examining the intersections of political, historical, cultural, social, and economic factors. Four main themes emerge: the resilience of transnational networks, migration as a coping mechanism, prolonged displacement, and the inconsistency of return and reintegration. The paper also discusses the challenges of conceptualizing migration and return in the Afghan context and reflects on relevant theoretical models for studying migration in Afghanistan. Additionally, it explores emerging research themes, including gender perspectives and political uncertainty. As Afghanistan grapples with a dynamic migration landscape, the insights gained from this study have broader implications for international migration studies.
Associations between sexual assault and romantic relationship functioning: A mixed-methods analysis
Authors: Person Abby I. , Frazier Patricia A. , Selvey-Bouyack Alicia M. , Anders Samantha L. , Shallcross Sandra L. , Simpson Jeffry A.
Published: March 2024

Background: Research on the relation between sexual assault (SA) and romantic functioning has yielded inconsistent results. The goals of the current studies were to examine this association while addressing limitations of past research; assessing revictimization, multiple victimization, and assault timing; and examining whether this association was moderated by neuroticism, attachment orientations, or perceived partner responsiveness. Design and Methods: College students (Study 1; N = 437) and community members (Study 2; N = 566) completed measures assessing SA, romantic functioning, attachment, neuroticism, and partner responsiveness. Study 2 used a mixed-methods approach. Data were collected via online surveys in psychology courses (Study 1) and on Prolific (Study 2). Results: In Study 1, SA was not associated with romantic functioning and this association was not moderated by attachment or neuroticism. In Study 2, SA survivors reported significantly poorer relationship quality and less partner trust, but not less sexual satisfaction. However, significant effects were small. Partner responsiveness did not moderate these associations, and revictimization, multiple victimizations, and assault recency were not related to poorer functioning. In qualitative data, the most common response was that the SA had not affected participants’ relationships. Conclusions: Relationships may be one area in which SA survivors demonstrate resilience.
The Evolution and Investigation of Markets, Macromarketing and Systems: A Special Issue in Honor of Roger Layton
Authors: Wooliscroft Ben
Published: March 2024

Roger Layton (1934–2021) spent his career investigating (macro)marketing systems. He left macromarketing a canon of research on the development of provisioning systems that will serve as the foundation for many scholars to come. The following commentaries and papers honour Roger Layton with a special issue of the Journal of Macromarketing on the Evolution and Investigation of Markets, Macromarketing and Systems.
Non-linearity Measure for POMDP-based Motion Planning
Authors: Hoerger Marcus , Kurniawati Hanna , Elfes Alberto
Published: March 2024

Motion planning under uncertainty is essential for reliable robot operation. Despite substantial advances over the past decade, the problem remains difficult for systems with complex dynamics. Most state-of-the-art methods perform search that relies on a large number of forward simulations. For systems with complex dynamics, this generally requires costly numerical integrations, which significantly slows down the planning process. Linearization-based methods have been proposed that can alleviate the above problem. However, it is not clear how linearization affects the quality of the generated motion strategy, and when such simplifications are admissible. To answer these questions, we propose a non-linearity measure, called Statistical-distance-based Non-linearity Measure (SNM), that can identify where linearization is beneficial and where it should be avoided. We show that when the problem is framed as the Partially Observable Markov Decision Process, the value difference between the optimal strategy for the original model and the linearized model can be upper-bounded by a function linear in SNM. Comparisons with an existing measure on various scenarios indicate that SNM is more suitable in estimating the effectiveness of linearization-based solvers. To test the applicability of SNM in motion planning, we propose a simple online planner that uses SNM as a heuristic to switch between a general and a linearization-based solver. Results on a car-like robot with second order dynamics and 4-DOFs and 7-DOFs torque-controlled manipulators indicate that SNM can appropriately decide if and when a linearization-based solver should be used.
Unstable Vancouver B1 periprosthetic femoral fracture fixation: A biomechanical comparison between a novel C-shaped memory alloy implant and cerclage wiring
Authors: Oh Seog-Hyun , Suh Yu-Sung , Eghan-Acquah Emmanuel , Yurevich Kollerov Mikhail , Won Sung-Hun , Baek Min Jung , Lee Sung-Jae , Choi Sung-Woo
Published: March 2024

Background

To compare the biomechanical stability of a novel, C-shaped nickel–titanium shape memory alloy (SMA) implant (C-clip) with traditional cerclage wiring in the fixation of a Vancouver B1 (VB1) periprosthetic femoral fracture (PFF).

Methods

In total, 18 synthetic femoral fracture models were constructed to obtain unstable VB1 fracture with an oblique fracture line 8 cm below the lesser trochanter. For each model, the distal portion was repaired using a 10-hole locking plate and four distal bi-cortical screws. The proximal portion was repaired using either three, threaded cerclage wirings or three, novel C-shaped implants. Specimens underwent biomechanical testing using axial compression, torsional and four-point bending tests. Each test was performed on three specimens.

Results

The C-clip was statistically significantly stronger (i.e., stiffer) than cerclage wiring in the three biomechanical tests. For axial compression, medians (ranges) were 39 (39–41) and 35 (35–35) N/mm, for the C-clip and cerclage wiring, respectively. For torsion, medians (ranges) were, 0.44 (0.44–0.45) and 0.30 (0.30–0.33) N/mm for the C-clip and cerclage wiring, respectively. For the four-point bending test, medians (ranges) were 39 (39–41) and 28 (28–31) N/mm; for the C-clip and cerclage wiring, respectively.

Conclusion

Results from this small study show that the novel, C-shaped SMA appears to be biomechanically superior to traditional cerclage wiring in terms of stiffness, axial compression, torsion and four-point bending, and may be a valuable alternative in the repair of VB1 PFF. Further research is necessary to support these results.
Mitotic activity: A systematic literature review of the assessment methodology and prognostic value in feline tumors
Authors: Bertram Christof A. , Donovan Taryn A. , Bartel Alexander
Published: March 2024

Increased proliferation is a driver of tumorigenesis, and quantification of mitotic activity is a standard task for prognostication. This systematic review is an analysis of all available references on mitotic activity in feline tumors to provide an overview of the assessment methods and prognostic value. A systematic literature search in PubMed and Scopus and a nonsystematic search in Google Scholar were conducted. All articles on feline tumors that correlated mitotic activity with patient outcome were identified. Data analysis revealed that of the 42 eligible articles, mitotic count (MC, mitotic figures/tumor area) was evaluated in 39 studies, and mitotic index (MI, mitotic figures/tumor cells) in 3 studies. The risk of bias was considered high for most studies (26/42, 62%) based on small study populations, insufficient details of the MC/MI methods, and lack of statistical measures for diagnostic accuracy or effect on outcome. The MC/MI methods varied between studies. A significant association of MC with survival was determined in 20 of 28 (71%) studies (10 studies evaluated other outcome metrics or provided individual patient data), while 1 study found an inverse effect. Three tumor types had at least 4 studies, and a prognostic association with survival was found in 5 of 6 studies on mast cell tumors, 5 of 5 on mammary tumors, and 3 of 4 on soft-tissue sarcomas. MI was shown to correlate with survival for mammary tumors by 2 research groups; however, comparisons to MC were not conducted. Further studies with standardized mitotic activity methods and appropriate statistical analysis for discriminant ability of patient outcome are needed to infer the prognostic value of MC and MI.
What Lies Behind Fare Evasion in Curb Parking Behavior? Evidence from Nanjing, China
Authors: Zhou Xizhen , Yan Jie , Ding Xueqi , Ji Yanjie
Published: March 2024

Frequent incidents of parking fare evasion pose ongoing challenges, placing parking management departments under pressure as a result of reduced parking revenues. The causal mechanisms behind parking fare evasion, as identified in existing studies, remain incompletely explained. To address this gap, our study utilized empirical data from Nanjing, China, employing a random forest methodology to elucidate the intricate and non-linear relationships among parking site attributes, weather conditions, and the built environment concerning curb parking fare evasion behavior. Additionally, we used the Shapley Additive Explanations method to clarify the pertinent variables. Our empirical findings emphasize the significant impact of parking site attributes, including departure time, parking space availability, and occupancy, on evasion behavior. Notably, our results underscore the necessity of strategically managing parking near scenic spots and points of interest (POIs) associated with accommodation during weekends. Conversely, on workdays, there is a need for strategic oversight of parking fees in the vicinity of government institutions, scenic spots, and workplace-related POIs. These research outcomes make valuable contributions to the existing literature on curb parking and provide actionable insights for improving urban parking management.
Challenges and Coping Strategies of Older Adults in the Aftermath of Kahramanmaraş Earthquake in Türkiye: A Qualitative Research
Authors: Kuru Alici Nilgun , Kalanlar Bilge
Published: March 2024

The aim of this study was to explore the post-earthquake experiences, difficulties, and coping strategies of older adults who experienced the Kahramanmaraş earthquakes that occurred in Türkiye in 2023. This research was designed as a qualitative descriptive study. The study was conducted with 21 (13 female and 8 male) older adults and the mean age of the participants was 70.2 (in the range of 65–85). In line with the data obtained from the participants, “ Fulfilling Basic Needs of Older Adults, Emotional Turmoil in Later Life, Healthcare Disparities in Aging, Adaptive Response of Older Adults” themes and sub-themes related to the theme were formed. Both physical and socio-emotional challenges, as well as coping strategies and support systems that older adults face in the aftermath of earthquakes, demonstrate unique characteristics for this demographic group. Therefore, it is recommended to plan programs by considering these differences while planning intervention programs before, during, and after the disaster.
Paraprofessional to Teacher: Attracting and Preparing Special Educators for a Critical Shortage
Authors: Fogle Keri C. , Pua Daisy , Wilt Beth
Published: March 2024

As the teacher shortage continues to sweep the country, Grow Your Own (GYO) programs designed to attract and prepare more individuals into the teaching ranks are gaining national attention, particularly those targeting special education. Assisting paraprofessionals who work with students with disabilities has long been considered as one strategy among the array of ideas to grow more teachers and retain them. The solution includes GYOs that provide paraprofessionals with tuition support to earn their degrees and teaching certificates. Yet, little is known about outcomes of programs that fund paraprofessionals to become teachers. The state of Florida funded GYO program has compiled outcome data on more than 200 paraprofessionals who received tuition support to obtain their degrees. Data support the notion that when provided with financial assistance, paraprofessionals do earn their degrees and apply for teaching certification. Retention data also indicate that they remain certified at commendable levels.