bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementasi Kurikulum 2013 di SMK Kota Semarang
Authors: Ayunda, Nurul Izza Wisudani Rahmaningtyas, Ismiyati,
Published: October 2020

The result of the observation showed that the teachers have prepared lesson plans
according to the Curriculum 2013 guidelines, however the lesson plans has not been quite
implemented in the learning process, in addition to the lack of the availability of the
infrastructures to support the learning process. The objective of the study was to determine
the extent to which the implementation of the Curriculum 2013 learning and the obstacles
encountered in the Archival subject by the teacher and students of 10th Office Administration
at SMK Negeri 9 Semarang. It was a qualitative research using the CIPP model of evaluation
method. The results of the study showed that: 1) the mechanism of the lesson plans
implementation in archive learning has been in accordance with Curriculum 2013
guidelines and the phases were complete. However, there were some inappropriateness, such
as the undelivered information about the scope of the subject matter and the assessment
technique, the lack of student involvement, and the absence of archive laboratory to support
the learning process, 2) the obstacles in the implementation of the lesson plans in archive
learning were from three sources, i.e. the teacher, the students, and the infrastructure.
Penguatan Manajemen Modal Kerja Sebagai Kelangsungan Start-Up Kawasan UNNES
Authors: Suwito Eko Pramono Ita Nuryana, Margunani,
Published: October 2020

Lack of knowledge about working capital management caused the sustainability of start-ups in UNNES area is still being low. It resulted that manager of start-ups are difficult to develop themselves. Therefore, it need for training to improve the skills in making good financial, so the sustainability of start-ups is reached. To increase of the existence and sustainability of start-ups are also required the reinforcement of working capital management by manager of the start-up. Then, focus of devotion is the owner and manager of the start-ups in UNNES area that gathered in HIPMI PT UNNES. Purpose of this devotion is improving and making good working capital management for the sustainability of start-up. Participants in this devotion 25 people. Procedure in this devotion is carried out by delivering of material on working capital management. In supporting of devotion, the dedication team arranges the module of working capital management. Outcome of this devotion is creating that the manger of the start-up can continue their start-up, so it can reduce the number of unemployment.
Pengaruh Gaya Kepemimpinan, Motivasi kerja, dan Disiplin Kerja Terhadap Kinerja Karyawan Kantor Notaris Panam
Authors: Liyas Jeli Nata
Published: October 2020

This study aims to examine and analyze the influence of leadership style, motivation and discipline to employee performance Notary in Pekanbaru Tambusai lord street. Data collected through questionnaires and conducted on 71 employees who are in the way Notary Tambusai lord Pekanbaru. Analysis of the data in this study using SPSS version 16. In this study did not use sampling techniques since the sample studied is the whole of the population, or so-called census data and testing techniques used in this study include validity, reliability with Cronbach Alpha , classic assumption test and multiple linear regression analysis, to test and prove the hypothesis penelitian.Hasil analysis shows that the leadership style of significant positive effect on employee performance, motivation of no effect and no significant effect on employee performance and discipline significant positive effect on employee performance
Pengelolaan Dana Desa di Kecamatan Balong Kabupaten Ponorogo
Authors: Muhammad Ridwan Eka Wardani Maretha Berlianantiya
Published: October 2020

Poverty often occurs in rural areas rather than urban areas, low education which results in low quality of human resources and lack of access is often the cause of rural poverty. In addition, most of the economies of rural communities rely solely on the traditional agricultural sector. Various poverty reduction policies have been implemented, including village fund policies. This study aims to examine the management of village funds in the Balong sub-district of Madiun Regency with a case study in the villages of Tatung and Karangmojo villages covering the management of village funds in Tatung village and Karangmojo village. Balong Subdistrict and the impact of empowerment in the villages of Tatung and Karangmojo, Balong District. This research was conducted in Balong Subdistrict, Ponorogo Regency with a Case study in Tatung Village and Karangmojo Village with qualitative methods. In the village of Tatung village funds are managed as tourist villages with a focus on Paragliding tourist rides. Whereas in Karangmojo village it is used for Bumdes in the form of Lovebird birds, providing Gapoktan assistance, and infrastructure development.
Tanggung Jawab Kurator Terhadap Penjualan Harta Pailit Jaminan Debitur PT Bank Rakyat Indonesia Agroniaga Tbk KC Pekanbaru (Studi Kasus Kepailitan Koperasi Karyawan Nusantara Lima)
Authors: Silitonga Richad Sahat
Published: October 2020

Proof of the responsibility of the curator in the sale of bankrupt assets based on the Bankruptcy case decision Number: 08 / Pdt.Sus-PKPU / 2015 / PN-Niaga Medan is unclear, because in the decision there is no explanation of the witness evidence submitted by the applicant or the respondent. So in the case of proof it has been legally flawed and violated Article 163 point b Herzein Indonesis Reglement (H.I.R), Article 184 points b Buitengewesten  Rechtsreglement  (RBg)  and Article  1866  points  b  Civil  Code  (KUH Perdata). In this ruling the author examines the lack of evidence that states the Respondent of the five archipelago employee cooperatives which were declared bankrupt by the Medan Commercial Court. Legal considerations by the panel of judges against the curator in the sale of bankrupt assets based on the PKPU case verdict Number: 08 / Pdt.Sus-PKPU / 2015 / PN.Mdn are inaccurate, because the decision of the panel of judges did not explain the duties of a curator in the sale of bankrupt assets which will cause a loss to the curator himself. So in this case illustrates that a judge does not carry out his duties as stipulated in Article 184 Herzein Indonesis Reglement (H.I.R).
Pemberdayaan Ekonomi Keluarga Melalui Usaha Peningkatan Pendapatan Keluarga Sejahtera (UPPKS) (Studi Kasus di Desa Sukorejo Kecamatan Saradan Kabupaten Madiun)
Authors: Waini Astuti Sudarmiani,
Published: October 2020

This study aims to determine the implementation of the UPPKS program, the role of UPPKS cadres, the supporting components of the UPPKS program and obstacles in family economic empowerment activities through the UPPKS program in Sukorejo Village, Saradan, Madiun. The type of research used is descriptive qualitative with a case study approach. Data sources used are primary data and secondary data. Data collection is done by observation, interviews and documentation. The validity of the data uses source triangulation. The results show, (1) The implementation of family economic empowerment through the UPPKS program in Sukorejo Village runs quite well in savings and loan activities. (2) The role of UPPKS cadres in Sukorejo Village is as facilitators in conveying what their members want to the UPPKS program organizers. (3) Supporting components in the implementation of UPPKS activities in Sukorejo Village are Village Village, Saradan PLKB, and BKKBN. (4) Obstacles in the process of family economic empowerment through the UPPKS program in Sukorejo Village, namely the existence of members who are less active in the activities of UPPKS groups and members who move domiciles, so that UPPKS members are reduced.
Implementasi Pendidikan Kewirausahaan Sebagai Character Building Mahasiswa Pendidikan Ekonomi UNPGRI Kediri
Authors: Efa Wahyu Prastyaningtyas Zainal Arifin,
Published: October 2020

Entrepreneurship is a course that aims to provide understanding and skills to students about entrepreneurs, in accordance with the learning objectives of being able to understand, analyze basic concepts of entrepreneurship and business ethics, create and use a trusted and effective business plan. This study aims to determine whether the implementation of entrepreneurship education affects the character building of UN PGRI Kediri economic education students in the practice of entrepreneurship, by looking at before and after getting KWU education whether it can generate character buliding for students. This study is classified as an experimental study using the Wilcoxon signed rank test design with one group pre test post test design. This study shows a positive result that entrepreneurship education has a significant effect on student character building.
Faktor–Faktor Yang Mempengaruhi Konsumsi Rumah Tangga di Komplek Perumahan_X Kelurahan Sidomulyo Pekanbaru
Authors: Herman Herman
Published: October 2020

Penelitian ini bertujuan untuk melihat Faktor-faktor yang mempengaruhi konsumsi masyarakat pada komplek perumahan _X Kelurahan Sidomulyo Pekanbaru. adapun teknik pengambilan sampel dalam penelitian ini adalah Random sampling yaitu sebanyak 55 orang. Variabel yang digunakan adalah pendidikan, pendapatan, jumlah anggota keluarga, dan konsumsi. Berdasarkan hasil analisis menggunakan regresi linier berganda menunjukan bahwa arah hubungan variabel bebas terhadap variabel terikat memiliki arah positif. Dan hasil uji secara parsial seluruh variabel bebas berpengaruh signfikan terhadap variabel terikat hal ini dibuktikan bahwa nilai t_hitung > t_tabel. Dan hasil uji_F diperoleh bahwa secara simultan berpengaruh signifikan terhadap variabel terikat dan hal tersebut dapat dilihat bahwa nilai F_hitung > F_tabel. Dan besarnya pengaruh variabel bebas terhadap variabel terikat adalah sebesar 61.3 persen.
Analisis Kesiapan Kerja Mahasiswa Di Era Revolusi Industri 4.0 Ditinjau Dari Soft Skills Mahasiswa
Authors: Kurniawan Moh. Usman
Published: October 2020

This research aims to know how many students are ready and less ready to face the era of the industrial revolution 4.0. Hopefully, the results of this research can provide solutions and recommendations regarding actions that universities should take, especially students, to be better prepared to face the industrial revolution 4.0. The number of samples used was 49 IKIP PGRI Jember students and final-semester students (semester 7 ≥). The data collection method uses a work readiness scale with 20 questions and 5 alternative answers, while data analysis uses data and uses the Rasch model. The results showed that 38 students (78%) had high job readiness, while the rest were classified as moderate. The elements of the student work-readiness scale item (item measure) show that the ability to work in IKIP PGRI Jember student teams is very high, exceeding other items.
Karakteristik Ekonomi Pada Pengguna Ganda Rokok Elektrik dan Rokok Konvensional Pada Mahasiswa di Kota Bandung
Authors: Herlina Silvani Purba Tambak Estro Dariatno Sihaloho,
Published: October 2020

The number of electric cigarette users in Indonesia has increased significantly. They used electric cigarettes to stop used conventional cigarettes. In fact, users of electric cigarettes cannot reduce the use of conventional cigarettes. This study wants to see what factors cause university students in Bandung to use electronic cigarettes and conventional cigarettes together. This study uses primary data of 124 users of electric cigarettes and conventional cigarettes collected through surveys in the city of Bandung. This study uses the Logistic regression method with STATA 14. The results show that the allowance of students from parents, the status of other family members who smoke conventionally, how long they use conventional cigarettes, number of conventional cigarettes consumed per day before using electric cigarettes make university students be difficult to stop using conventional cigarettes after using electric cigarettes. The use of electric cigarettes and conventional cigarettes together will have a worse health impact. While the age and amount of e-cigarette expenditure reduces the possibility to consume e-cigarettes and conventional cigarettes together
Hubungan Kepribadian Proaktif Dengan Perilaku Kerja Inovatif Pada Generasi Millenial
Authors: Putri Dhien Amalia
Published: October 2020

The millennial generation is the generation that has dominated the labor market in recent years. This generation is being faced with various challenges due to technological developments that are happening. Current technological developments are forcing the players in the goods and service industries to innovate in order to be able to increase the competitiveness of companies. Innovative work behavior can be raised by individuals in several ways, one of which is with a proactive personality. This study aims to measure the relationship between proactive personality with innovative work behavior in the millennial generation. The study was conducted on 315 millennials who are full time employees in goods and services companies in the city of Surabaya. Innovative work behavior is measured using the Innovative Work Behavior Scale, which is proven to be reliable (α = 0.760), while the proactive personality is measured using the Proactive Personality Scale that has proven to be reliable (α = 0.734). The analysis in this study uses Pearson's Product Moment analysis with a significance value of 0,000 (p <0.05) which shows the relationship between proactive personality and innovative work behavior in the millennial generation. These results indicate that the higher the proactive personality an individual has, the higher the innovative work behavior exhibited by the individual. The results of this study also found a significant relationship between sex, years of service and age on innovative work behavior
A Density Functional Theory Investigation of the Reaction of Water with Ce2O-
Authors: Harb Hassan , Hratchian Hrant
Published: October 2020

Cerium suboxide clusters have been shown to react with water to yield H2. Since reactions of metal oxides with water are of great fundamental and practical importance in energy science, detailed study of this reaction can provide new key knowledge for future catalyst design. Using density function theory calculations, we identified and report complete reaction pathways for two spin-states of Ce2O– reacting with H2O. Additionally, examining the molecular orbitals of initial and final cerium oxide clusters, we found that metal d electrons facilitate the reduction of water. This work provides new understanding of this reaction and insights to the reactivity enhancements for cerium-doped surfaces.
Physical intervention to relieve pain in women with primary dysmenorrhoeaA new perspective
Authors: Sujatha B  , Jagatheesan Alagesan  , Tinu Priya R  , Sarumathi S
Published: October 2020

Dysmenorrhoea is menstruation with pain involving abdominal cramps. It can affect females daily life activities and productivity. Aim of the study is to find the effectiveness of exercise and various stretching techniques used as a treatment protocol for primary dysmenorrhoea. Forty-five students were selected based on a questionnaire. Out of this, 38 subjects were selected and divided into two groups as the control group (n=19) and the experimental group (n=19). Each group were given separate exercise protocol. The post-test value will be taken after eight weeks (2 menstrual cycles). The exercises were performed from the sixth day of the menstrual cycle. The results were determined from the statistical analysis. It has been revealed that there is a significant improvement in the experimental group than the control group. In the control group, the pre-test mean is 7.84, with the standard deviation being 1.30 and the post-test mean 5.10 with a standard deviation of 1.96. P-value in the control group was less than 0.0001. In the experimental group, the pre-test mean is 7.52, with the standard deviation being 1.54 and the post-test mean being 4.57 and a standard deviation of 2.19. P-value in the experimental group was less than 0.0001. The overall results show that there is a significant improvement in pain (VAS) in both treatment groups. The results obtained suggested that both strengthening and stretching techniques have a positive effect on the treatment of primary dysmenorrhoea. The improvement is more significant in the experimental group.
Production and Nutritional Quality of Traditional Indian Millet Mixture of Rice, Pearl Millet and Urad Dal
Authors: Caroline Jeba R  , Priyanka S  , Priyanka M
Published: October 2020

Millet mix was prepared for its traditional values. The prepared sample was analyzed for its chemical and nutritional value, and by using the cost-efficient method, the nutritional content of the final product was enhanced. The improved sample was checked for its nutritional content. The objective is to make a comparison between standard and enhanced samples. ingredients were prepared in a powdered form of a sample in four different ratios. The standardized ratio of the ingredients used to make the samples were found by using tests. In the standardized ratio normal (S1) and nutrition enhanced (S2) samples were prepared using the three ingredients. For nutrition enhancement, the method of sprouting was used. Various tests were conducted for the standardized sample to verify its nutritional content, commercializing ability, microbial analysis, analysis etc. The nutritional content Analysis of the normal and nutrition enhanced samples (S1) and (S2) was done. The sample (S2) was nutritionally rich when compared to the normal sample (S1). All other test had more or less coinciding results for both the samples (S1) and (S2). By comparing the nutritional content, a conclusion arrives that the sample (S2is nutritionally rich when compared to (S1). Microbial and Physical properties results show that the product is efficient to be commercialized and stored to a specific period without microbial contamination in powdered form. The nutrient-rich mass is suitable for all age group.
A Study on Norm Scores-Box and Block Test for Children Age with 6-10 Years Among Indian Population
Authors: Christopher Amalraj Vallaba Doss  , Palanivel R M  , Syed Mohamed Sadath  , Muhil Sakthivel
Published: October 2020

The study aims to compare the scores of dominance and non-dominance in developing children that are important in clinical practice. The capacity to perform complex muscle and nerve acts that produce development; fine engine aptitudes are little developments; net engine abilities are enormous developments. An observational quantitative study was conducted to establish the new developmental norms for children on the Box and Block Test. This study included 400 volunteers’ 221(55.25%) males and 179(44.75%) females with the age of 6 to10 years. The signed parental consent before participation was obtained in this study. Out of 400 total populations, the male’s right dominance is 20(93.6%) is a difference from left dominance 14(6.4%). The female right dominance is 171(95.5%) is more than that of male dominance and used to compare the left dominance 8(4.5%). The Block and Test Box are easy, simple, and suitable for children. This test aids the therapists to evaluate the efficacy of the interventions tailored to improve manual dexterity. These kids may profit essentially from early mediation focusing on the improvement of handwork.
Current prescription status of anti hypertensives in cardiology
Authors: Shaik Faizan Ali  , Mahaveer Singh  , Birendra Shrivastava  , Konda Ravi Kumar
Published: October 2020

The main of our study is to determine the prescription pattern and perform cost analysis of the patients who were visiting the cardiology department of the hospital. Anti hypertensive drugs has vast classification and most of the studies suggest that cardiovascular events are one among the most leading contributor to global patients in regards to mortality and morbidity. Cardiovascular events are also considered as silent killer because its symptoms are unpredictable. should be prescribed properly. So we have undergone a prospective observational study which shows mean age of 60.13 + 9.22. We found that there is much difference in gender for exposure of cardiovascular events. We observed dual therapy was effective in management for . We found total average of direct medical cost was Rs.5641.12 and indirect medical cost was Rs.677.27. The patients prescription was and documented to know the level of and compliance with guidelines. The economic burden experienced by the patients were to know the rational use of drugs and to lay a way for further research related to economics.
Assessment of Knowledge, Attitude and Practices towards menopause among postmenopausal women - A Cross-sectional study
Authors: Saswatika Beura  , Lipilekha Patnaik  , Manisha Sahoo  , Sumitra Pattanaik
Published: October 2020

Majority women attain menopause without having adequate knowledge and approaches to cope with the menopausal changes. So, they face many physical and psychological disorders during their menopause. Awareness, positive attitude and healthy practice towards menopause can help women to reduce their menopausal symptoms. Women who are had menopause more than 12 months were included in the study. In this study, 80.8% women had poor knowledge and 73.1% women having positive attitude towards menopause. But none of the participants reported healthy practices in their menopause. 44.2% women had knowledge that postmenopausal bleeding was abnormal, 36.5% women said that menopause is associated with many chronic diseases and 32.7% said that menstruation does not stop suddenly at the time of menopause. In our study 90.4% of participants positively accepted their menopause. Knowledge score was significantly associated with age and education. The perceived poor knowledge and practice towards menopause require more efforts for creating mass awareness about this issue.
Intracranial And Intraorbital Rosai Dorfman Disease
Authors: Sivapriya G Nair  , Jina Raj  , Sajesh K Menon  , Suhas Udayakumaran  , Roshni P R
Published: October 2020

Rosai Dorfman disease is a rare histiocytic disorder. It is also known as Sinus Histiocytosis. It is with massive lymphadenopathy involves an overproduction of a type of white blood cell. The disease is rarely associated with intracranial and intraorbital involvement. Intracranial Rosai-Dorfman can mimic meningioma. Other pathologies also underline its pathologies. Here, we report a nine-year-old boy with a history of proptosis of the right eye and presenting with multiple skull lesions. Histopathological study revealed Sphenopetroclival lesion, which features that of Rosai Dorfman Disease. His MRI scan of the brain was taken, which showed evidence of right optic nerve meningioma with sella and suprasellar extension, causing severe proptosis. The child underwent right frontotemporal craniotomy with petrosectomy and Transylvanian, subtemporal approach to multicompartmental Rosai-Dorfmans lesion. After four months, the patient had a recurrence of the disease on which chemotherapy and steroids were started, which also did not show much response while taking an MRI scan. A corticosteroid is a useful option in the Central Nervous System Rosai Dorfman disease treatment. But this patient showed a negative outcome to the treatment.
Effectiveness of structured teaching programme on knowledge regarding the management and prevention of complications of Gastro-Esophageal Reflux disease among patients with GERD
Authors: Dayana. B. A. A
Published: October 2020

Gastro esophageal reflux disease (GERD) is one of the common gastrointestinal complaints presented in developing and developed countries. Barrett’s esophagus and esophageal adenocarcinoma are the major complications of GERD. A Quantitative research approach, pre-experimental one group pre-test post-test design was used to conduct the study to assess the effectiveness of structured teaching programme on knowledge regarding the management and prevention of complications of Gastro esophageal reflux disease (GERD) among patients with GERD. A total of 60 Samples were selected by non-probability purposive sampling technique. A pretest was done using a semi-structured questionnaire, followed by which, a structured teaching programme was provided. A post-test using a same semi-structured questionnaire was given to the same samples. Before STP, 76.7% of the subjects had an inadequate level of knowledge score, and none of them had an adequate level of knowledge score. But after the pedagogical way of effective STP, none of the patients had an inadequate level of knowledge score, 16.7% of them had moderate and 83.3% of them had an adequate level of knowledge score. Elder and graduated subjects were significantly associated with their post-test level of knowledge score regarding management and prevention of complications of GERD. The study proved that STP was immensely effective for the patients with GERD (c2=58.00 at P=0.001 level of significance) attending the Gastroenterology outpatient department at RGGGH, Chennai.
Effect of Deep Cervical Flexor training on Respiratory Functions in Chronic Neck Pain patients with Forward Head Posture
Authors: Sonia Pawaria  , Sheetal Kalra
Published: October 2020

Protruded chin posture is one of the commonly seen postural problem associated with patients having chronic neck pain. It is also known by names Forward Head Posture (FHP) or anteriorly translated head posture. The FHP causes an alteration in mechanics of rib cage which leads to a reduction in mobility of thorax and abdomen, decreased movement of the diaphragm, reduced ventilatory effectiveness of diaphragm and reduced efficacy of abdominals and intercostals muscles during respiration. Therefore this study was executed to check the effectiveness of deep cervical flexor exercises on Craniovertebral angle and pulmonary functions. It was a comparative experimental study design. Based on the study's selection criteria, the total numbers of 100 subjects were taken and divided into Experimental and Control groups. In-depth Cervical flexor training with the conventional Physiotherapy was given to subjects of the experimental group. Control group subjects received only Conventional Physiotherapy for six weeks. The baseline measurement was taken on day one of the studies. The digital camera assessed the Forward head posture by measuring Craniovertebral Angle (CVA). Spirometry determined pulmonary functions (FEV1& FVC). All measurements were repeated at the end of the 6th week. The baseline measurement and measurement at the end of 6th week were compared by using the t-test. Considerable improvement in Craniovertebral angle and functional status of the lung, resulted in subjects who were given in-depth cervical flexor training along with the conventional Physiotherapy treatment (p< 0.05). Therefore it is suggested that deep cervical flexor exercises improve the head posture and also correct the biomechanics of respiratory muscles. Deep neck flexor training can be considered as an efficient technique in lessening protruded chin posture.
Analyses of In-vitro antioxidant and anticancer activity of Cissus quadrangularis stem extract in osteoblastic cell line -UMR- 106
Authors: Suchitra M R  , Abinaya P  , Sampathkumar P  , Sumathi S  , Poornima A  , Parthasarathy S
Published: October 2020

Cancer is one of the leading causes of death worldwide with an estimated 7.8 lakh deaths in 2018 in India. Osteosarcoma, a primary tumour of the bone is the second highest cause of bone cancer related death in young people. It is treated with chemotherapy, radiation, and surgery which cause side effects. Certain traditional plants may have antitumour activities. This research aimed to evaluate the invitro antioxidant and apoptosis induced activity of stem extract of cissus quadrangularis (CQ) on osteoblastic cell line (UMR-106). Various extracts of CQ was subjected to phytochemical screening and antioxidant studies. Ethanolic extract of CQ showed maximum phytoconstituents and better antioxidant activity for both DPPH(2,2-diphenyl-1-picryl-hydrazyl-hydrate)and FRAP(Ferric reducing antioxidant potential) assay. The UMR-106 cell line was treated with different concentrations of the extract ranging from 25μg to 400μg for varying time periods. The dose and time optimization of the ethanolic extract was evaluated in the osteoblastic cell line (UMR-106) using MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) which showed IC50 value with 200μg/ml at 24 hours. There was a reduction in the percentage of cells by 50% in the treated group by SRB assay showing the cytotoxic potency of the extract. Flow cytometry analysis indicated that the extract of CQ induced apoptosis in UMR-106 cell line. Ethanolic extract of CQ has antioxidant effects, also inducing G0/G1 arrest and apoptosis in osteoblasts, suggesting that this might represent a novel and effective agent against bone cancer.
Current Trends Of ESRD Patients with Ozonedialysis: Ozone “The Wonder Therapy” For Dialysis
Authors: Kavitha D  , Jeyalakshmi S  , Sridevy S  , Baby Caroline
Published: October 2020

Ozone therapy is known to be the current successful method of dialysis which is first taken up in Germany. Medical oxygen known to be an ataxic generator is used to generate medical ozone, ensuring the inert contact of all the materials related to ozone. Surprisingly this useful and effective therapy is not recognised in our country like India but is widely accepted and practised in the countries like South America, Europe, Russia, Thailand, Bulgaria, Indonesia, Cuba, etc.; since over 70 years it is used as a successful method of treating various illnesses; like used to halt the progression of diabetes, Kidney diseases, detoxification of the body, coronary artery disease, etc.; Ozone is prepared freshly "on-site" just before starting the session, as it should be administrated immediately after its generation. They should be accurate, reliable and should project the ozone concentration (1-80μg/ml) as reproducible measurements by using a suitable device. Ozone Therapy has learnt to be an effective therapy for ESRD patients irrespective of the stages of disease dealt. The importance and the applications of Ozone therapy in the current medical field are discussed and emphasised in the present review. This review may help the researchers in planning further research to improvise the therapy or to sophisticate the method of implementation, and it also helps in delivering details of the therapy for better understanding of the medical practitioners.
SGOT and SGPT level of Wistar rat after the administration of Channa micropeltes extract
Authors: Amy Nindia Carabelly  , Deby Kania Tri Putri  , Nadya Rezki  , Maharani Laillyza Apriasari
Published: October 2020

Channa micropeltes is a local peatland water species which has been utilized as an alternative of Channa striata among South Kalimantan population to anticipate the scarcity of Haruan species. Channa micropeltes originate from the same family of Channa striata in which both fishes contain albumin. Albumin is proven to accelerate wound healing, thus can be produced as capsules. The capsulate form of Channa micropeltes extract will later be deployed as an alternative herbal medicine for the acceleration of mucosal wound healing. Nevertheless, a study of a hepatological profile is pivotal to assess the safety of its consumption. The present study aimed to analyze the effect of Channa micropeltes extracts capsulate oral administration at 0.7 g dosage on SGOT and SGPT level of Wistar rat liver. This was a real experimental study with post-test only and control group design. The samples comprised of 12 rats which were distributed into three groups namely a treatment group of 0.7 g Channa extract capsulate, a positive control group of 0.7 g Channa striata extract and a negative control group without any treatment for 28 days. The level of SGOT and SGPT were 19.41 IU/L and 29.52 IU/L in Channa micropeltes treatment group, 31.95 IU/L and 28.71 IU/L in the positive control group of 0.7 g Channa striata extract, 25.07 IU/L and 18.90 IU/L in the negative control group. Hence, there is no effect of Channa micropeltes extract capsulate oral administration at 0.7 g dosage on SGOT and SGPT level of Wistar rat liver.
Image processing for early detection of Alzheimer’s disease using Iridology
Authors: Asuntha A  , Sai Kalyan Reddy R  , Vamshikrishna K  , Premsagar N
Published: October 2020

Alzheimer's disease is caused by genetics, personal lifestyle and other environmental factors. It is an irreversible disease that slowly destroys the brain memory cells. There are no specific methods for the detection of Alzheimer's disease. The primary symptoms of Alzheimer's disease are memory loss, difficulty in thinking, a problem in writing and speaking and others. Iridology is alternative research that has gained more popularity in recent years, which studies the alterations of the iris in correspondence with the organs of the human body. The combination of digital image processing with Iridology gives an excellent opportunity to explore and learn about different neuronal diseases, specifically Alzheimer's disease. In this work, MATLAB software is applied to determine the colour, pattern and other factors that show the existence of Alzheimer's disease. The noise in the iris image is removed by the Gaussian filter, followed by histogram analyses and cropping. The Hough circle transform is used to identify the region of interest and to convert the circular iris image into rectangle form. In the training methods, the SVM and CNN classifiers are used to classify whether the person has Alzheimer's disease. Finally, the results are compared with the real-time images.
Knowledge, Attitude and Practice Towards On Nail Tic Disorders
Authors: Mohamed Arsath N  , Gayatri Devi R
Published: October 2020

Nail tic disorder is one such disorder which has been reported in the nineteenth century. Nail tic disorder is a body focused repetitive behavior. Nail tic disorders are developed by individuals to cope up the stress and anxiety level. Nail tic disorder are effectively treated with the help of multiple aids like psychological methods, pharmacological methods. A cross sectional online survey was conducted between dentist and genital students with a self prepared questionnaire and the knowledge and awareness level among the participants about nail tic disorder was analyzed using online platform survey monkey. It is evident from the study conducted that most of the people develop this habit from childhood and it is practiced to cope up with stress levels and it is clear that most of them are aware about the consequences and treatment modalities of this disorder. Nail tic disorder is a example for overlap between dermatology and psychiatry. It is one of the problems that everyone practices in their life time but yet it is a poor studied topic and it is rarely understood.
Comparative Evaluation of Different Irrigation Techniques with Conventional Irrigation Technique for the Removal of Double Antibiotic Paste from Root Canal-An in vitro study
Authors: Samrudhi Khatod  , Anuja Ikhar  , Pradnya Nikhade  , Manoj Chandak  , Kaustubh Khatod  , Akshay Jaiswal  , Madhulika Chandak  , Chanchal Rathi  , Nidhi Motwani
Published: October 2020

Complete removal of infection, rendering root canal free of an organism is the prime aim of endodontic treatment. It cannot be achieved alone by biomechanical preparation due to the complexity of root canal treatment. Therefore the use of intracanal medicament is a must. The antibiotic paste is frequently used intracanal medicament, usually in regenerative cases. Hence the aim of the is to compare different irrigation technique for removal of double antibiotic paste from root canal through a stereomicroscope. 36 single-rooted were standardized to root length of 12mm then instrumented by Protaper rotary file up to size F4. Irrigation was done using sodium hypochlorite in between instrument change. The root canal was dried using paper point and filled by DAP and then randomly allocated to 3 groups(n=12) according to irrigation system used: conventional syringe irrigation (CSI), Passive ultrasonic irrigation(PUI), EndoVac (EV). Roots were then longitudinally sectioned using the diamond disk and studied under a stereomicroscope using a scoring scale. Data were evaluated using one way ANOVA and Tukey test. Among all experimental group CSI was least efficient. PUI and EV showed greater efficiency but no significant difference between PUI and EV, but a significant difference between CSI and PUI, EV (p< 0.05). Use of irrigation activation system results in efficient removal of DAP compared to CSI.
Review of phytochemistry, biological activities and therapeutic potential of Brachylaena discolor
Authors: Alfred Maroyi
Published: October 2020

Brachylaena discolor DC. is a shrub or tree widely used as herbal medicine in southern Africa. Brachylaena discolor is indigenous to Botswana, Eswatini, Mozambique, South Africa, Zambia and Zimbabwe. This study was aimed at reviewing the phytochemistry, biological activities and therapeutic potential of B. discolor. Information on phytochemistry, biological activities and therapeutic potential of B. discolor was collected from online sources such as Google Scholar, PubMed and Science Direct, and pre-electronic sources such as books, book chapters, theses and journal articles obtained from the University library. This investigation revealed that the bark, leaf, root, stem and twig infusion or decoction of B. discolor are mainly used for magical purposes and as anthelmintic and tonic, and traditional medicine for female infertility, skin infections, renal problems, diabetes, gastro-intestinal problems and respiratory infections. Chemical compounds identified from B. discolor include alkaloids, flavonoids, phenolics, phlobatannins, saponins, sesquiterpene lactones, steroids, tannins and terpenoids. Ethnopharmacological review showed that B. discolor and phytochemical compounds identified from the species have anticancer, anthelmintic, anti-hyperglycaemic, antibacterial, cytotoxicity, antifungal, antidiabetic, antioxidant and leishmanicidal activities. Advanced ethnopharmacological research on B. discolor should focus on the possible biochemical mechanisms of both the crude extracts and identified phytochemical compounds including toxicological, in vivo and clinical studies to corroborate the traditional medicinal applications of the species.
Determination of transverse diameter and longitudinal axis in patients with cholecystitis and cholelithiasis by computed tomography to rule out gallbladder carcinoma
Authors: Vishram Singh  , Durgesh Singh  , Ashutosh Tandon  , Yogesh Yadav  , Richa Tiwari
Published: October 2020

The aim of the article is to the determination of transverse diameter and longitudinal axis in patients with cholecystitis and with the help of CT scan in the north Indian population for the estimation of epidemiology. Patients with cholecystitis and of ages between 17-80 years irrespective of gender were included in the study (cases). All patient's cases (100) and controls (100) were advised the night before that did not eat or drink. Control groups (Normal Gallbladder) were collected when patients are comprised of other abdominal disease diagnosed by computed tomography. The mean age of controls and cases was 47.24±11.57 and 45.20±16.22 years, respectively studied by computed tomography. More than half of cases (62%) and 50% of controls were females. The transverse diameter was significantly (p=0.0001) higher among cases (36.42±15.52 mm) than controls (24.12±9.11 mm) studied by computed tomography. Longitudinal axis was significantly (p=0.0001) higher among cases (33.23±14.73 mm) than controls (21.75±8.69) studied by computed tomography. Transverse diameter>25 correctly predicted cholecystitis and by CT in 38.5% cases with sensitivity and specificity of 77% (95%CI=68.8-85.2) and 74% (95%CI=55.7-74.3%) respectively. Longitudinal axis >25 correctly predicted cholecystitis and by CT in 34.5% cases with specificity and sensitivity of 69% (95%CI=59.9-78.1) and 71% (95%CI=62.1-79.9%) respectively. We concluded in this study, increased transverse diameter and longitudinal axis were observed. Good sensitivity and specificity of these two parameters were also found in predicting cholecystitis and by computed tomography. All such cases should be subjected to biopsy for examination to rule out the gallbladder carcinoma for better prognosis.
Antimicrobial-stewardship Knowledge, attitude, and practice among professional physicians in Saudi hospitals
Authors: Abdulrahman Hadi Almutiri  , Abdul Bari Mohd  , Tahani Mohammad Al Rahbeni
Published: October 2020

Antimicrobial stewardship (AMS) is of vital significance to tackle the antibiotic resistance. Insights of physicians is important for implementation of AMS. Therefore, present study was conducted to assess the knowledge, attitude and practices regarding antibiotic stewardship among professional physicians in Riyadh, Saudi Arabia. A cross-sectional questionnaire-based survey was conducted among professional physicians between January 2020 to April 2020 in clusters of Saudi hospitals. The self-administered and closed ended questionnaire encompassed of informed consent, demographics information and questionnaire which included 7 items for knowledge, 10 for attitude and 8 for practices. Chi-square test and Fisher’s exact test was performed to assess the relationship of knowledge, attitude and practices with gender and medical specialty of the study participants along with descriptive statistics. A p value below (p<0.05) was considered significant for all the statistical purposes. A total of 413 medical practitioners participated in this study. Most of the participants were male 280 (67.8%), aged 31-40 years 163(39.4%). The term antimicrobial stewardship was known to 55.9% of participants and 65% of participants knew the difference between and bactericidal antimicrobial agents (). 71.9% participants opined that can be prevented by using specific . 89% of participants do not prescribe on demand of patients. Health professionals should be adequately trained regarding usage of and their consequences to curb the menace of quickly developing AMA resistance.
Effect of Hypervitaminosis D3 on Liver, Kidney Functions in White Rats
Authors: Haitham L. Al-Hayali
Published: October 2020

The research was undertaken to evaluate the effects of vitamin D3 on the liver and kidney functions through some haematological and biochemical parameters. The results illustrate that high doses (30000 and 50000 IU) of vitamin D3 significantly reduce the rats' body weights in about 46% additionally much of symptoms like weakness, the rigidity of limbs, neurological irritation, difficulty in movement, respiration and deaths occurrence. The results also showed that the high doses vitamin D3 has a significant decreased in Red Blood Corpuscles (RBCs), Hemoglobin (Hb), Packed Cell Volume (PCV), Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), White Blood Corpuscles (WBCs), Lymphocytes (Lymph), Monocytes (Mono), Granulocytes (GRA) and Platelets (PLT) compared with the control group. In contrast, the Mean Corpuscular Hemoglobin Concentration (MCHC) and Platelet Distribution Width (PDW) significantly increased after 20-30 days of treatment . Besides, the results demonstrated a significant decrease in Alanine aminotransferase (ALT), Total Protein (TP), Creatinine (Cr) and increase in aspartate aminotransferase (AST), Blood Urea Nitrogen (BUN), Urea. While albumin did not give any significant differences. As well the study proved significantly increase in serum vitamin D3 concentration compared with the control group after 20-30 days of treatment. Since vitamin D3 can be beneficial for the organisms, but the overdoses of the vitamin can alter some parameters in the body.
The Prognostic Significance of Global Histones Deacetylation in Colorectal Cancer Patients Treated with Fluoropyrimdine Therapy
Authors: Mariam A. Fouad  , Salem S E  , Hussein M M  , Zekri AR N  , Hafez H F  , Shouman S A
Published: October 2020

To study the impact of fluoropyrimidine (FP)- therapy on the acetylation level of histones (H3 and H4), and its correlation to treatment outcome in colorectal cancer (CRC) patients. Total histone protein was extracted, and the level of global histones (H3 and H4) acetylation was determined in the peripheral blood of 66 CRC patients before treatment with FP therapy, and also in 48 and 32 of those patients after 3 and 6 months of treatment, respectively. Clinicopathological stratification of patients was conducted for subgroup analysis. After three years of follow up, event-free survival (EFS) and the hazard of recurrence and progression were determined by Kaplan –Meier and COX regression analyses, respectively. Baseline CRC patients showed global H3 hyperacetylation by 160%, but H4 hypoacetylation by 87% relative to healthy control. FP therapy significantly reduced global H3 and H4 acetylation levels especially in subgroups of CRC patients > 45 years, females, with right colon tumours, with normal baseline levels of CEA and CA19.9, with negative lymph nodes and negative metastasis, and also in the patients who showed no signs of recurrence or progression after three years of follow up. Survival analyses showed decreased median EFS time and increased the hazard of recurrence and progression in patients with high CEA (HR= 3.38, P= 0.023), positive metastasis (HR= 1.16, P<0.001), and H4 hypoacetylation <87% (HR= 1.55, P=0.014). FP therapy-induced reduction in the global level of histones acetylation declared in subgroups of CRC patients with excellent prognostic features.
Obtention, yields, chemical-microbiological properties and amino acids profile in a flour from Sacha Inchi (Plukenetia volubilis l.)
Authors: Priscilla. Mora-Aguirre  , Luis. Romero-Hidalgo  , Edgar. Landines-Vera  , Roberto. Ordoñez-Araque  , Mario. Valdez-Díaz
Published: October 2020

Sacha inchi seed (Plukenetia volubilis) has long been used for its high protein content and for its essential fatty acids (omega 3, 6 and 9). After obtaining the oil, a by-product called dry cake is generated, recent studies have shown that this cake, which is generally wasted, has a high protein content. In this investigation, the residue from the oil extraction from the Sacha Inchi seed was used, this dried cake was subjected to several treatments (dehydration, grinding and sieving) to obtain fine flour. To this product, chemical physical analyzes were performed (moisture, proteins, lipids and ashes), microbiological (microorganisms and mycotoxins) and amino acid profile. The flour had 47% of proteins, 10% of lipid fraction and 20% of fiber, the microbiological result showed that there was no presence of microorganisms due to bad manipulation or pathogens (E. coli), no presence of mycotoxins (furosin, ochratoxin and zearalenone), the most interesting result was found in the amino acid profile, the total amount of non-essential amino acids present in the flour was 601.32 g.kg-1, while in essential amino acids the presence of threonine, valine, leucine and phenylalanine (77, 35, 40 and 50 g.kg-1 respectively). These results allow us to determine that sacha inchi seed can not only provide its benefits with its oil, dry cake represents an interesting unconventional raw material because of its high protein content and can be used in the food industry to enrich different food products low in this macromolecule.