bluuebunny/crossref_metadata_2025 huggingface dataset:
The Assumption of Zero Leakage from Permanently Abandoned Wells on the Norwegian Continental Shelf
Authors: Vikane Rune , Selvik Jon Tømmerås , Abrahamsen Eirik Bjorheim , Lohne Hans Petter
Published: November 2021

Quality data is essential for calculations of expected leakage in wells post Permanent Plug and Abandonment (PP&A). Such data may come from surveys studying hydrocarbon leakage to the marine environment. However, recent literature suggests that current regulatory practices for environmental surveys are suboptimal, giving reason to question the assumption that wells have experienced zero leakage from the deep reservoir post PP&A on the Norwegian Continental Shelf (NCS). We investigate whether such an assumption is credible.

The credibility of the assumption of zero leakages is investigated through a review of literature addressing the integrity of wells post PP&A on the NCS, with particular emphasis on a 2021 report from the Norwegian Environmental Agency (NEA). Based on the review, the strength of knowledge supporting the assumption that no wells on the NCS have experienced leakages from their deep reservoirs is discussed. The implications of the uncertainty associated with the assumption of zero leakage on the NCS, the rationale for collecting more relevant data, and how these data may be obtained is also discussed in brief.

The NEA report details the current regulatory practice for environmental surveys on the NCS. This regulatory practice, as it is described in the NEA report, give limited support to a zero leakage assumption. Norwegian regulations require two environmental surveys post Cessation of Production (CoP). These surveys may however occur in the period between CoP and PP&A, and the closest test stations are generally located 250 meters from the wells. Environmental surveys carried out that far from the well, and possibly prior to PP&A, influence data quality. We argue that the environmental survey data claiming zero leakage, lack sufficient evidence. Thus, based on the reviewed literature outlining the current environmental survey practice, although PP&A well design on the NCS should build on sound principles, we are not able to conclude on the assumption of zero leakage.

The interest in risk-based PP&A approaches is increasing globally, and risk-based approaches rely on credible leakage calculations. The failure rates used in these leakage calculations should be based on quality data. The NEA report and other literature indicate that the quality of post PP&A leakage data on the NCS is questionable, and in some cases the data are non-existent. The paper includes suggestions on how to improve the regulatory practice related to environmental surveys.
Optimisation of Plug and Abandonment Process Utilising Nuclear Technology for through Tubing Cement Evaluation
Authors: Valouiski Konstantin , Zainuddin Afiq Azreen , Kalistratov Andrei , Abd Rajab Ahmad Zawawi , Farhan Zulkipli Siti Najmi , Misren M. Mokri , Balachandran Arun , Zulkefli Siti Nor Dahliawati , Awal Adli Zaim
Published: November 2021

One of the major factors in the well plug and abandonment (P&A) process is to provide a proper isolation in aging wells which requires effective placement of the cement plug in the most suitable location in the well. Identifying cement placement is usually achieved by running cement evaluation logging to define the quality of cement and top of cement depth behind and in between the casing annuli.

However, this comes with significant costs due to tubulars or casings removal requirement prior to logging run in order to conduct a proper evaluation. This is necessary since acoustic and ultrasonic based cement evaluation technologies will not be able to determine cement quality behind several casing layers if the job is done through tubing. The cost involved is substantial especially in offshore operation in which the daily operating rate is significantly higher compared to an onshore operation.

A new approach to cement evaluation has been tested during the well P&A campaign in one of the aging oil fields in offshore, Peninsular Malaysia. A nuclear based technology comprised of Gamma-Gamma, Neutron-Neutron and Neutron-Gamma measurements were utilized to evaluate cement integrity behind production casing and between production casing as well as intermediate casing while logging run was deployed through tubing in memory mode.

Log data was compared with acoustic and ultrasonic based cement evaluation technology that was deployed after the tubing was pulled out in one of the wells. Results had shown a consistent finding with the conventional ultrasonic based cement evaluation data. Based on the logging results, cement placement design and depth was finalized and the cement plug was successfully tested as outlined in the well P&A guideline.

Findings from this logging run had provided useful insight to the operator to validate the nuclear based thru tubing cement evaluation technology for wells P&A application. Huge cost saving could be captured through this application as a result of eliminating total rig days via offline cement evaluation logging and based on the results obtained planning for the exact well P&A design requirement prior to the rig arrival.

This paper will outline the method, tools used to acquire the cement evaluation data and its operational advantages. Acquired data will be presented and discussed along with the methodology used to determine cement volume and top of cement depth behind and in between the casings.
Application of Inverted Umbrella Technique in Offshore
Authors: Parmar Yogesh Pravin
Published: November 2021

The oil and gas industries are setting a new achievement every day by fulfilling the energy security of almost all the nations. With the continuous rise in the demand of a hydrocarbon, industries are facing many new challenges while fulfilling it. One of the major concerns is the safety of an environment and safety of working professionals that HSE Department is continuously focused in. The industry has been in continuous upgradation since its inception to counter all the challenges. Inverted Umbrella Technique (IUT) is the recent innovation in the industry and this could be further more conceptualized by adding its role into the energy industries. This could turn out as a major breakthrough in the oil and gas domain from HSE perspective. The paper here aimed for providing efficient solution by setting up the system that could help us to drawdown the rising concern in the safety of the environment. Inverted Umbrella Technique (IUT) could roll down the new horizons for the offshore productions system in oil and gas industries. The concept is focused on the minimal loss of methane during exploitation of gas hydrates as well as focused on the prevention of oil spill and reducing the damage that blowout of oil or gas well can make to the environment while making sure that industries do not suffer any kind of major capital loss and making it safe for industries to not face many health, safety, and environment (HSE) norms that are decided by the government and most important is, it will help us to create a safe environment for aquatic species living around the offshore platform and nearby.
Soziale Interaktionen in digitalen Lernumgebungen
Authors: Loy Christine
Published: November 2021

Corona-bedingt musste im Sommersemester 2020 ein Seminar im Bereich der Grundschuldidaktik Sachunterricht, das als Forschendes Lernen konzipiert war, in ein digitales Format umgewandelt werden. Es wird explorativ untersucht, welche Bedeutung die Lehramtsstudierenden in ihren Reflexionsportfolios (N=31) den sozialen Interaktionen im Forschungsprozess zuweisen und wie sie dabei die Virtualität der Lernumgebung thematisieren. Theoretischer Ausgangspunkt ist das Modell der Community of Inquiry (Garrison et al. 1999, 2010), dessen drei Elemente teaching presence, cognitive presence und social presence für die Analyse aufgegriffen werden. Die Ergebnisse zeigen, dass ko-konstruktive Prozesse in hohem Masse auch in einer digitalen Lernumgebung möglich sind, d. h. Austausch auf der sozio-kognitiven Ebene erfolgreich stattfindet. Die Hochschuldidaktik sollte sich, neben den technischen und räumlichen Herausforderungen durch die digitale Lehre, jedoch auch mit den sozio-emotionalen Wirkungen von digitalen Lehrformaten befassen, da von den Studierenden vor allem die fehlende physische Präsenz als Mangel erlebt wird.
CONTRIBUIÇÕES DO PROJECT MODEL CANVAS NA REELABORAÇÃO DO PROJETO POLÍTICO PEDAGÓGICO
Authors: Alves Paula Trajano de Araújo , Monteiro Biatriz De Sousa , Félix Camila Mesquita , Souza Andrea Moura da Costa
Published: November 2021

Este artigo discorre sobre uma metodologia de elaboração de projetos chamada Project Model Canvas (PMC) e teve como objetivo geral investigar como o PMC pode contribuir para o processo de elaboração ou reelaboração do Projeto Político Pedagógico (PPP). São objetivos específicos deste estudo: expor as orientações legais sobre a estruturação do PPP; compreender a composição e funcionalidade do PMC e apresentar o PMC como instrumento mediador na produção do PPP. Utilizou-se a abordagem qualitativa apresentando um caráter exploratório e utilizando-se da pesquisa bibliográfica e documental para a estruturação da investigação. É necessário ressaltar que, este estudo não possui a intenção de deslegitimar as diversas formas de desenvolvimento do Projeto Político Pedagógico, mas antes, carregou-se a intenção de apresentar uma alternativa simples, prática e possível de organização para a elaboração de um documento basilar no plano escolar. E assim, conforme a organização proposta pelo PMC, espera-se que essa metodologia contribua de modo eficaz para elaborar e reelaborar o PPP escolar.
TÜRKİYE'DE METAL SEKTÖRÜNDE ÇALIŞAN SAĞIRLAR VE İŞİTME ENGELLİLERE İLİŞKİN BİR DURUM ANALİZİ
Authors: KALKAN Ömür Kaya , KARABULUT Şener
Published: November 2021

Bu araştırmanın amacı, metal sektöründe çalışan sağır ve işitme engelli bireylerin istihdamına yönelik betimsel bir analiz yapmaktır. Bu amaçla, betimsel araştırma türlerinden tarama araştırması kullanılmıştır. Araştırma kapsamında, 55 şirkette istihdam edilen 1.502 sağır ve işitme engelli çalışana ait veriler, şirketlerin insan kaynakları birimi aracılığı ile elde edilmiştir. Araştırmanın sonuçları, Türkiye’de metal sektöründe çalışan engelli bireylerin büyük çoğunluğunu erkeklerin oluşturduğunu (%87) ve çalışanların yarısından fazlasının (%53) engelli kadrosunda istihdam edildiğini ortaya koymaktadır. Şirketler engelli çalışan istihdam ettiklerinde, ekstra eğitim ihtiyacı ve sürekli denetim (%13,8) gereksinimi ile karşılaşacaklarını düşünmektedirler. Metal sektöründe çalışan engelli bireylerin yaklaşık %67’sinin işitme engeli bulunduğu ve iş yaşamında karşılaştıkları en büyük zorluğun (%41,6) iletişim problemleri olduğu belirlenmiştir. Sağır ve işitme engelli çalışanların işe alımlarının büyük bir kısmı resmî kurumlar aracılığıyla (%43,3) gerçekleştirilmiştir. Araştırma sonuçlarına dayanarak, metal sektöründe çalışan engelli işgücünün iyileştirilmesine yönelik politika ve uygulamalarda, cinsiyet eşitsizliğini (%87-%13) gidermek adına kadınlar lehine bir ayırımcılığa öncelik verilmesi önerilebilir. Gelişen teknolojinin sunmuş olduğu imkânları da kullanarak engelli çalışanların uygun eğitimci ve eğitim materyalleri ile desteklenmesi oldukça önemlidir.
Overview of environmental airflow energy harvesting technology based on piezoelectric effect
Authors: Zou Huajie , Cai Fuhai , Zhang Jianghua , Chu Zhenyu
Published: November 2021

With the development of environmental energy harvesting technology, the research focus gradually develops from the energy harvester itself to the energy harvesting system of coupled environmental vibration sources, in which environmental airflow energy harvesting technology based on the piezoelectric effect is an important research direction. Here, the study status and development trend of piezoelectric energy harvesting were reviewed and summarized including rotation types, vortex-induced vibration types, flutter types and resonant types. It was found that the rotational multi-array energy harvesters are easy to scale, and the vortex-induced vibration and the flutter energy harvesters are poor adaptability for wide range of airflow velocity, and the resonant types can effectively improve excitation energy and output power. In order to improve power generation capacity and broaden the range of airflow velocity, energy harvesting with multiple frequency excitation and multi-piezoelectric array are future main development tendencies.
Análise da temperatura do ar, precipitação, evapotranspiração e índice hídrico do município de Itapetinga-BA
Authors: Carvalho Tatiane de Oliveira
Published: November 2021

Para a realização desse estudo foram considerados alguns elementos do clima, como temperatura, precipitação, evapotranspiração e índice hídrico do município de Itapetinga - BA, no período de 1961 a 1990. O objetivo foi de analisar as variações climáticas do município com uma perspectiva de compreender o comportamento do clima local e seus possíveis efeitos na região e, também, fornecer subsídios para planejamento regional. Foram utilizados dados meteorológicos do Instituto Nacional de Meteorologia (INMET), com um recorte temporal dos anos de 1961 a 1990. Com os resultados obtidos conclui-se que, o município que possui um clima que varia de semiárido a úmido, apresenta temperaturas que oscilaram entre 19,9ºC e 25,3ºC. O índice de evapotranspiração foi superior à precipitação, com exceção do mês de novembro. O município apresenta déficit hídrico com grande variabilidade, principalmente dos meses de julho para setembro. Devido as características climáticas do município de Itapetinga torna-se necessário medidas mitigadoras que levem em consideração os aspectos do clima local e, também, no que tange a planejamentos ambientais, disponibilidade hídrica, produção agrícola e, principalmente, nas tomadas de decisões.
Observações sobre os impactos hidrológicos na barragem do rio maranguapinho em Maranguape-CE
Authors: Veras Pedro Meneses Chaves
Published: November 2021

O presente artigo visa fazer uma analise parcial dos im-pactos hidrológicos na barragem do Rio Maranguapinho localizada no município de Maranguape-CE correlacio-nando os fatores de qualidade da água e as dinâmicas socioambientais das áreas adjacentes. Essa pesquisa ocor-reu através da coleta de dados de órgãos governamentais referentes a recursos hídricos no estado do Ceará, visita a área estudada, uso do conhecimento teórico já obtido e consulta a bibliografia referente ao assunto. O trabalho tem por intuito refletir sobre o potencial hídrico dessa barragem para o município de Maranguape-CE e o uso atual da mesma tendo em vista as condições climatológi-cas do nosso estado e região nesse grande período de seca e mais especificamente no próprio município onde se localiza esse reservatório. O “Projeto Rio Maranguapi-nho” teve a maioria dos seus objetivos alcançados e maio-ria destes foi a jusante da barragem. O planejamento am-biental de recuperação do rio não alcança os setores a montante da barragem. As áreas próximas a barragem tem carência de saneamento básico e as áreas mais afastadas poluem os trechos urbanos dos rios tributários com inú-meros esgotos clandestinos resultando aceleração dos processos de eutrofização e na diminuição da qualidade da água.
N-Terminal Pro-C-Type Natriuretic Peptide: The Novel Marker in Selected Disease Units
Authors: Tomasiuk Ryszard
Published: November 2021

Background:

Amino-terminal pro-C-type natriuretic peptide (NT-proCNP) is the N-terminal fragment of the CNP precursor. NT-proCNP occurs in an equimolar concentration with CNP in human plasma and is considered to be a marker of the extent of CNP biosynthesis. A recent study has shown associations between plasma NT-proCNP and blood pressure; it is also an independent predictor of death and cardiac readmission in people with unstable angina. Beyond that, recent studies have focused on the applicability of assessing NT-proCNP peptide levels in the diagnosis of diseases with different etiologies but the same denominator, i.e., inflammation.

Methods:

This study reviewed recent results on the usability of NT-proCNP peptide levels in the diagnosis of diseases accompanied by statistical analysis of previously reported results.

Results:

The data obtained confirmed the applicability of the assessment of NT-proCNP levels in biological fluids in diseases, such as Parkinson's disease, sepsis, meningitis, and asthenozoospermia.

Conclusion:

The reported results demonstrated that NT-proCNP is helpful in a variety of diseases. Furthermore, changes in serum or CSF levels of NT-proCNP reflect only inflammatory states related to general inflammation. Local inflammation does not trigger an increase in NT-proCNP level.
Tannic Acid Exhibits Adjuvant Activity by Enhancing Humoral and Cell-Mediated Immunity Against BSA as a Protein Antigen
Authors: Cabral-Hipólito Nidia , Molina-Ramírez Brenda Sarahí , Castillo-Maldonado Irais , Meza-Velázquez Rocío , García-Garza Rubén , Gauna Sergio-Everardo Velázquez , Delgadillo-Guzmán Dealmy , Hernández-Herrera Alejandro , Ramírez-Moreno Agustina , Cruz Jorge Haro Santa , Espino-Silva Perla-Karina , Pedroza-Escobar David
Published: November 2021

Background:

Immunization or vaccination is the process of inducing artificial immunity
against an antigen taking advantage of the mechanisms of immunological memory. Current
vaccines include substances known as adjuvants, which tend to improve the immunogenicity of the
antigen, reduce the antigen quantity employed, and boost the immune response in weak responders.
Unfortunately, only a few vaccine adjuvants are approved for human use.

Objective:

Thus, the objective of this study was to investigate the effect of Tannic acid on humoral
and cell-mediated immunity against bovine serum albumin (BSA) as a protein antigen in Wistar
rats.

Method:

In order to establish the Tannic acid concentration to test it as an adjuvant, the lethal
dose 50 and maximum non-toxic dose were calculated through cytotoxicity and hemolytic assays
with J774 A.1 cell line and rat erythrocytes by resazurin reduction method and UV/vis spectrophotometry.
Thirty Wistar rats were divided into 5 groups that included two controls without antigen
and three treatment groups of adjuvants plus BSA as a protein antigen. The rats were immunized in
a 30-day scheme. Blood samples were collected for humoral immunity analysis by means of immunoglobulin
quantification, isotyping and antigen-antibody precipitation inhibition analysis. Rat
peritoneal macrophages and splenocytes were isolated for cell-mediated immunity analysis by
means of nitric oxide quantification from adjuvant stimulated peritoneal macrophages and lymphocytes
proliferation assay.

Results:

Tannic acid was capable of increasing the immunogenicity of the antigen; besides, it was
able to stimulate cell-mediated immunity by means of increased lymphocyte proliferation. Moreover,
Tannic acid improved the humoral response by means of increased specific antibodies titers.
These activities may be attributed to pattern recognition receptors stimulation.

Conclusion:

Tannic acid was considered biocompatible when tested in vivo because the concentration
tested did not show cytotoxicity or hemolytic effect, and there was no detrimental effect observed
on the animals’ health. These results show Tannic acid as a promising candidate for vaccine
adjuvant.
Millennium Nutrient N,N-Dimethylglycine (DMG) and its Effectiveness
in Autism Spectrum Disorders
Authors: Dhanjal Daljeet Singh , Bhardwaj Sonali , Chopra Chirag , Singh Reena , Patocka Jiri , Plucar Bohumir , Nepovimova Eugenie , Valis Martin , Kuca Kamil
Published: November 2021

:

Autism is a neurodevelopmental disorder belonging to the autism spectrum disorder
(ASD). In ASDs, the individuals show substantial impairments in social communication,
repetitive behaviours, and sensory behaviours deficits in the early stages of their
life. Globally, the prevalence of autism is estimated to be less than 1%, especially in high-
-income countries. In recent decades, there has been a drastic increase in the incidence of
ASD, which has put ASD into the category of epidemics. Presently, two US Food and
Drug Administration-approved drugs, aripiprazole and risperidone, are used to treat
symptoms of agitation and irritability in autistic children. However, to date, no medication
has been found to treat the core symptoms of ASD. The adverse side effects of conventional
medicine and limited treatment options have led families of autistic children to
turn to complementary and alternative medicine (CAM) treatments, which are perceived
as relatively safe compared to conventional medicine. Recently N, N-dimethylglycine (DMG),
a dietary supplement, has emerged as a useful supplement to improve the mental
and physical state of children with ASD. The current review discusses ASD, the prevalence
of ASD, the CAM approach, and the efficacy of CAM treatment in children with
ASD. Moreover, it highlights the chemistry, pharmacological effect, and clinical studies
of DMG, highlighting its potential for improving the lifestyle of children with ASD.
Quantitative Estimate of the Resonance Effects in Some Unsaturated, Monocyclic,
and Aromatic Hydrocarbons Based on the Renewed Optical Exaltations
Authors: Zaitsev Boris A.
Published: November 2021

:

The present review discusses a new viewpoint on refractometry as the oldest experimental
physical method, whose scientific potential in the estimation of structural effects in
organic chemistry has been missed so far. The author demonstrates that upon certain adjustment
and redesign of refractometry, this potential can be tapped and successfully used to determine
a type of π-electron interaction, delocalization degree of π-electrons in organic compounds,
and to perform quantitative estimates of resonance effects in unsaturated, (polycyclic)
aromatic, and other polyconjugated systems (e.g., fullerenes). The method for accurate separation
of molar refraction into additive and constitutive components was suggested; the method
is based on the specially developed additive scheme. It was revealed that the negative deviations
from additivity for cycloalkanes depend linearly on the number of carbon atoms in the
ring. Excellent linear correlations between renewed optical exaltations, the number of π-electrons in a conjugated
system, and experimentally found resonance energy (determined from hydrogenation heat values) were demonstrated.
Angular coefficients of the correlation series (ρ-constants) are considered as a criterion of classification, which
characterizes the degree of mobility of π-electrons in the conjugated system of a given type. It is emphasized that
the development of methods for precise measurement of the constitutive components of molar refraction may become
a useful additional source of information about resonance and other effects in organic and polymer chemistry.
Heterogeneity of Tau Deposition and Microvascular Involvement in MCI and AD
Authors: Bryant Annie G. , Manhard Mary K. , Salat David H. , Rosen Bruce R. , Hyman Bradley T. , Johnson Keith A. , Huang Susie , Bennett Rachel E. , Yen Yi-Fen
Published: November 2021

Background:

Reduced cerebrovascular function and accumulation of tau pathology are
key components of cognitive decline in Alzheimer’s disease (AD). Recent multimodal neuroimaging
studies show a correlation between cortical tau accumulation and reduced cerebral perfusion.
However, animal models predict that tau exerts capillary-level changes that may not be fully captured
by standard imaging protocols.

Objective:

Using newly-developed magnetic resonance imaging (MRI) technology to measure capillary-
specific perfusion parameters, we examined a series of mild cognitive impairment (MCI) and
AD patients with tau positron emission tomography (PET) to observe whole-brain capillary perfusion
alterations and their association with tau deposition.

Methods:

Seven subjects with MCI or AD received Flortaucipir PET to measure tau deposition
and spin-echo dynamic susceptibility contrast (SE-DSC) MRI to measure microvascular perfusion
(<10μm radius vessels). Gradient-echo (GE) DSC and pseudocontinuous arterial spin labeling (PCASL)
MRI were also acquired to assess macrovascular perfusion. Tau PET, microvascular perfusion,
and cortical thickness maps were visually inspected in volumetric slices and on cortical surface
projections.

Results:

High tau PET signal was generally observed in the lateral temporal and parietal cortices,
with uptake in the occipital cortex in one subject. Global blood flow measured by PCASL was reduced
with increasing tau burden, which was consistent with previous studies. Tau accumulation
was spatially associated with variable patterns of microvascular cerebral blood flow (CBF) and oxygen
extraction fraction (OEF) in the cortex and with increased capillary transit heterogeneity (CTH)
in adjacent periventricular white matter, independent of amyloid-β status.

Conclusion:

Although macrovascular perfusion generally correlated with tau deposition at the
whole-cortex level, regional changes in microvascular perfusion were not uniformly associated
with either tau pathology or cortical atrophy. This work highlights the heterogeneity of AD-related
brain changes and the challenges of implementing therapeutic interventions to improve cerebrovascular
function.
Computer-Aided Detection of Human Lung Nodules on Computer Tomography Images via Novel Optimized Techniques
Authors: Seelan Lim J. , Suresh L. Padma , K.S. Abhilash , P.K. Vivek
Published: November 2021

Background:

As the mortality rate of lung cancer is enormously high, its impact is also
extremely higher than the other types of cancer. Lung malignancy is thus considered one of the deadliest
diseases with a high death rate in the world. It is reported that nearly 1.2 million people are diagnosed
with this disease and about 1.1 million individuals are died due to this type of cancer every year.
The early detection of this disease is the only solution for minimizing the death rate or maximizing the
survival rate. However, the timely identification of lung malignant growth is a complex process and
hence various imaging algorithms are employed in the process of detecting lung cancer on time.

Aim:

The Computer-Aided Diagnosis (CAD) is highly beneficial for the radiologist to rapidly detect
and diagnose the irregularities in advance. The CAD systems usually focus on identifying and detecting
the lung nodules. As the treatment of this disease is provided on the basis of its stages, the early
detection of cancer has to be given much importance. The major drawbacks of existing CAD systems
are less accuracy in segmenting the nodule and staging the lung cancer.

Objective:

The major aim of this work is to categorize the lung nodules from the CT image and classify
the tumorous cells for identifying the exact position of cancer with higher sensitivity, precision, and
accuracy than other strategies.

Methods:

The methods employed in this study are listed as follows: (i) For the process of de-noising
and edge sharpening of lung image, the curvelet transform was used. (ii) The Fuzzy thresholding technique
was used to perform lung image binarization and lung boundary corrections. (iii) Segmentation
was performed by implementing the K-means algorithm. (iv) By using Convolutional Neural Network
(CNN), different stages of lung nodules, like benign and malignant, were identified.

Results:

The proposed classifier achieves optimal accuracy of 97.3%, a sensitivity of 98.6%, and a
specificity of 96.1%, which are significantly better than the other approaches. Thus, the proposed approach
is highly helpful in detecting lung cancer in its early stages.

Conclusion:

The results validate that the proposed algorithms are highly capable of classifying the
lung images into various stages, which effectively helps the radiologist in the decision-making process.
Bilirubin and Epigenetic Modifications in Metabolic and Immunometabolic
Disorders
Authors: Sarabi Mostafa Moradi , Babaeenezhad Esmaeel , Amini Maral , Kaviani Mozhgan , Naghibalhossaini Fakhraddin
Published: November 2021

:

Bilirubin is the main waste product of heme catabolism. At high concentrations, bilirubin may cause toxicity, especially in the brain, kidney, and erythrocytes. Membrane and mitochondrial dysfunction, oxidative stress, apoptosis, necrosis, endoplasmic reticulum stress, excitotoxicity, inflammation, and epigenetic modifications are the main mechanisms of toxicity triggered by bilirubin in susceptible organs. Many studies have shown that there is an interaction between bilirubin and epigenetic modifications in metabolic and immune diseases. In this review, we first outline the toxicity mediated by bilirubin and then summarize the current knowledge linking bilirubin and epigenetic modifications in metabolic and immunometabolic disorders.
Sustainable tourism model in the new normal era
Authors: Sunardi Sunardi , Roedjinandari Nanny , Estikowati Estikowati
Published: November 2021

The Bromo TenggerSemeru area is a strategic area for national and world tours with natural and cultural potential. Sustainable tourism management is needed so that it area becomes a destination that has been beneficial to the community for a long time to make the area a sustainable tourist attraction; stakeholders and local communities need to be prepared. This study aims to examine the sustainable tourism management model with qualitative and quantitative research methods with descriptive analysis to identify and explore the socio-cultural aspects of society, the environment, economic growth, tourist satisfaction, and community welfare. This study resulted in findings in the form of a sustainable tourism management model in the new normal era as the primary goal of the National Tourism Development pattern based on natural and cultural beauty with the central pillars being environmental conservation, cultural preservation, tourist satisfaction, a healthy economy, and community welfare. Tourism must be able to coexist with other sectors to minimize the impact of the inherent vulnerability in tourism, tourism stakeholders need to change the tourist target market and type of tourism in order to adapt to the (post) pandemic situation.
Enhancing customer loyalty through product innovation and perceived value
Authors: Setyaningrum Retno Purwani
Published: November 2021

This study aims to investigate the factors considered as important by consumers of Batik fabric created by entrepreneurs in Bekasi, West Java, Indonesia, and the relation to the customer satisfaction level. This research is quantitative research where data were collected using self-administered questionnaires distributed in the Bekasi district in West Java province. To test the relationship modeling between variables, this study used Structural Equation Modeling using Amos 16.0 software. Data were collected using questionnaires which distributed to respondents targeted with the help of enumerators. The results show that innovation and perceived value can increase customer satisfaction, which then has an impact on increasing customer loyalty and trust. In other words, customer satisfaction only serves as a bridge between innovation and perceived value with customer loyalty and trust. This is because there is no direct influence between innovation and perceived value on customer loyalty. Customer loyalty is an important aspect for Batik entrepreneurs in Bekasi in developing their business. Customers are satisfied with what they get from the innovative efforts of entrepreneurs in Batik production in Bekasi. This indicates that customer satisfaction can increase customer loyalty and trust to use a particular product.
Developing environmental integration teaching materials to improve cognitive flexibility
Authors: Kasirah Irah , Nadiroh Nadiroh , Abbas Hafid
Published: November 2021

This study aims to develop an innovative model of environmental integration learning in boosting cognitive flexibility. The research method used a Research & Development with the Dick and Carey development model. The sampling technique uses random sampling techniques. There are two groups of teachers. Data analysis used descriptive statistics and t-test to verify product differences and effectiveness. The output is in the form of teaching materials for environmental education learning strategies. Results showed that there was a very significant difference between the post-pre-test treatment score 19.68, higher than the post-pre-test score of the control 9,12. There was an increase in teachers' cognitive flexibility about environmental integration learning effectively and significantly after reading the teaching materials.
The concept of "principle" as an element of law
Authors: Aleshkova Irina A.
Published: November 2021

The article is devoted to the characterization of the concept "principle" in jurisprudence. The main approaches associated with the specifics of the expression of the concept "principle" in law (structural and semantic) are identified and analyzed. It is explained that the content of the concept’s "principle" can be replenished with new characteristics, in connection with which there is a need for new forms of their legal verbalization. In the context of law, the understanding of principles is identified with moral values. Among them are individual freedom, conscientiousness, honesty, truthfulness, obedience to the law, love for the Motherland, disinterestedness, tolerance, rejection of violence, theft, slander and envy, kindness and mercy, loyalty to the word, respect for elders, respect for honest work, etc. Attention is drawn to the metaphysical nature of the principles in law, which is expressed, firstly, in the fact that principles in law are a complex multifaceted phenomenon of the synthesis of human consciousness and social practice, in fact, the first reason for the emergence of the norms of constitutional law; secondly, in the fact that they are not formally subject to change in time, they either exist or not, while their content evolves in time and space; thirdly.
The right to a justice court: implementation of the practice of the European Court of human rights in the Ukrainian judiciary
Authors: Denysova Alina V. , Blaga Alla B. , Makovii Viktor P. , Kaliuzhna Yevheniia S.
Published: November 2021

The purpose of this study is to reveal the content of the right to a fair trial and the state of its provision in Ukraine through the prism of court decisions of Ukrainian courts of various instances and the relevant practice of the European Court of Human Rights. The methodological basis of the study is a set of philosophical and ideological, general and special scientific methods and techniques of scientific knowledge, including dialectical, systemic, structural and functional methods, as well as methods of analysis and synthesis. It is identified that the right to a fair trial in legal science, judicial practice is considered in its constituent elements and relevant manifestations, including fairness and publicity of the trial, compliance with the signs of independence, impartiality, legality, observance of the rule of law, equality of participants, and proceedings within reasonable time limits. Each of the elements, mentioned and features of the right to a fair trial is subject to appropriate interpretation in the context of the relevant decisions of the European Court of Human Rights during the review of case materials in national courts of the signatory states to the Convention.
Digital information security: corona-crisis impact on the accountants, business analysts and auditors training
Authors: Nazarova Karina , Nezhyva Mariia , Metil Tetіana , Hordopolov Volodymyr , Prystupa Liudmyla , Moyseyenko Olesya
Published: November 2021

The article considers the impact of transformation processes on business in the context of digitalization. Equally important is the study of the impact of these processes on the training of professionals whose work has had a direct impact on these transformations – accountants, business analysts and auditors. These specialists are faced with the task of analyzing the impact of the facts and determining the change in business development strategy in the context of global digitalization. The field of audit both in the world, in general, and in Ukraine, in particular, was able to adapt extremely flexibly to the new realities of functioning in the digitalized world. In this article, the authors reveal the main trends of digitalization of audit in the conditions of economic transformation and limited business practices caused by this global pandemic of 2019-2020. At the same time, the processes of digital transformation are the driving forces of the economy. Computer technology is becoming increasingly involved in reforming the audit institution and changing the trajectory of the auditor's role in such a society.
Intercultural communication competence
Authors: Biletska Oksana , Lastovskyi Valerii , Semchynskyy Kostyantyn
Published: November 2021

The study outlines the role of intercultural communication as a crucial component of diplomats and international professionals’ training, which increases the effectiveness of interaction with representatives of different cultures in performing professional duties. Conditions of civilizational development, achievements of science, innovative technologies, requirements of public life, the priority of foreign policy activity have led to the deepening of people's and cultures’ interaction. Because of such interaction of both individuals and cultures, diplomatic relations between different states have gained a special status. The diplomatic relations are based on intercultural communication as a tool of international cooperation aimed at promoting foreign policy interests of different states, as well as ensuring international cooperation and developing long-term formal and informal ties between government institutions, international actors, diplomatic missions, and political leaders. All these cause the intensification of intercultural communication processes that become systemic. With the research methods being study, analysis, and generalization, the study was aimed at revealing the concept of intercultural communication competence as the diplomats and international affairs specialists’ ability to choose and implement a speech act depending on the goals and content of professional speech through language, as well as mastery of communication strategies and tactics.
Audit indicators and financial performance of manufacturing firms in Nigeria
Authors: Ehiedu Victor Chukwunweike , Toria Gladys
Published: November 2021

This study investigated audit Indicators and financial performance of manufacturing firms in Nigeria during the period 2003-2020 (18 years). The researcher used three firms Unilever Nigeria Plc., Beta Glass Plc. and Meyer Plc. The dependent variable was measured with earnings per share (EPS), while the independent variables were measured with auditor's independence (AUIND), Audit Firm Size (AUSZ), Audit Committee (AUCMT), audit committee financial expertise (AUCFE). Time-series data were used and the researcher obtained it from the annual report and account of the firms under study. The estimation technique was Ordinary least square (OLS), normality, serial correlation, and heteroskedasticity test was carried out with the aid of E-views 9 statistical package. The study found that audit committee (AUCMT) and audit committee financial expertise (AUCFE) have a significant impact on earnings per share of Unilever Nigeria Plc as the p-value t-statistics is below 5% significant level. Also, the Audit Committee (AUCMT), audit independence (AUIND) and audit committee financial expertise (AUCFE) have a significant impact on earnings per share of Beta Glass Plc and Meyer Plc as the p-value t-statistics are below 5% significant level. Globally the p-value of the three manufacturing firms understudy is below 5% significant level.
Comparative analysis of gender-oriented research
Authors: Zoirova Aziza
Published: November 2021

This article analyzes the research conducted by world scientists in the field of gender, identifying the relevance and necessity of the issues raised in them through scientific methods. In particular, scholars have studied the gender phenomenon, gender parameters, as well as the semantic grouping and gynocritical analysis generated through the gender component. A scientific approach to this work has been expressed. In the analysis of the research, it is substantiated by the fact that the issues in this area in Uzbek translation studies are not sufficiently studied.
La storia degli edifici, la memoria dei luoghi. le architetture dei Gardella in Alessandria
Authors:   Politécnico de Turín, Italia, Dameri Annalisa
Published: November 2021

Due architetti, padre e figlio, protagonisti della cultura architettonica italiana del Novecento. Un committente illuminato, proprietario del cappellificio che esporta in tutto il mondo un cappello che sta per entrare nel mito, il “Borsalino”. Una città, Alessandria, che, a inizio secolo, è ancora priva di una serie di servizi fondamentali e che vedrà, grazie ai finanziamenti della famiglia Borsalino, la costruzione di una serie di infrastrutture tra cui un sanatorio antitubercolare. La memoria collettiva costruisce intorno alla fabbrica e al sanatorio (studiati e apprezzati dalla critica architettonica) affetti e timori: molto si deve alla fabbrica, ricordata come motore economico per l’intera città. La decisione, negli anni Ottanta, di demolire quasi totalmente il cappellificio suscita negli abitanti una violenta reazione: si vedono privati del proprio passato e la demolizione della ciminiera, fortemente danneggiata e con gravi problemi strutturali, ma simbolo riconosciuto della città, sarà letta come un sopruso delle ragioni economiche sulle questioni più affettive
El estilo como expresión de la capacidad imitativa humana: una estrategia pedagógica para las artes visuales
Authors:   Universidad del Valle, Colombia, Flórez González Fernando
Published: November 2021

El campo actual de la educación en artes visuales insiste en señalar negativamente los conceptos de imitación y estilo como algo que deberíamos pasar por alto o, al menos, algo que no deberíamos tener en cuenta en el plan de estudios. La mayoría de los requisitos en los trabajos artísticos apuntan a que los estudiantes «escuchen sus propias voces» y obvien las influencias históricas, el conocimiento fundamental de las tradiciones creativas y su propia manifestación social: los estilos o los modelos. Este texto se articula como un ejercicio analítico, etnográfico y de revisión de tres componentes de la imitación: ético, estético y epistemológico, desde tres autores modernos: Girard, Gombrich y Rizzolatti, respectivamente. A su vez, rescata el uso de los modelos o los estilos como estrategias pedagógicas para la investigación y la enseñanza de las artes visuales.
Worship with Children: Agentive Participation in Dutch Protestant Contexts
Authors: van Leersum-Bekebrede Lydia
Published: November 2021

Children take part in liturgical-ritual activities. In Sunday services, children’s church, Sunday school, and special services, children sit in pews, respond to Bible stories, and perform liturgical actions like singing in a choir, welcoming people, saying a prayer, or participating in the Lord’s Supper. Based on participant observations and interviews, this book describes and analyzes the variety of worship practices with children in Dutch Protestant contexts. A central concern is how people adapt worship to suit children and how children contribute to worship. The conclusions show children as agentive participants in worship. In addition, the conclusions nuance the debate on intergenerational worship, highlight the importance of spirituality for both adults and children, and explore how the material environment influences worship. This practical theological research gives a better understanding of Dutch Protestant liturgical rituals with children and their theological significance.
AN ASSESSMENT ON EARLY WARNING SYSTEM: INITIAL SURVEY ANALYSIS
Authors: Mohd Hussain Mohd Ramzi , Rabe Noor Suzilawati , Zen Ismawi , Tukiman Izawati , Muda Rahsidi Sabri , Mamat Ahmad Fadhli
Published: November 2021

In Cameron Highland, Lembah Bertam area and further downstream villages in Susu Dam area are prone and vulnerable to the highest occurrence of floods especially during monsoon season. Thus, Early Warning System (EWS) were set up to avoid or to reduce the impact of natural hazard turns disasters such as floods, landslides and storms with the aim to reduce the vulnerability and disaster risks that signifies the effectiveness of EWS in the realisation of affected community. To test the awareness and preparedness of community in the selected area, a questionnaire survey was employed as the data collection method. The questionnaire survey was conducted before the direct engagement on the EWS information with the community. Using the mixed sampling method of cluster random sampling, a total of 800 respondents from 11 villages, and 5 main ethnicity groups were involved in the survey. From the result, there was a positive relationship showing that respondents who claimed they knew about the EWS from information signage were those from the older age category and earninghigher monthly income. On the other hand, there is a negative relationship between respondents’ age and monthly income against other sources that indicates respondents who claimed they knew about the EWS from other sources were those in the younger age category and have low monthly income.
Predicting Video Game Addiction Through the Dimensions of Consumer Video Game Engagement: Quantitative and Cross-sectional Study
Authors: Abbasi Amir Zaib , Rehman Umair , Afaq Zahra , Rafeh Mir Abdur , Hlavacs Helmut , Mamun Mohammed A , Shah Muhammad Umair
Published: November 2021

Background

Video games are expanding exponentially with their increased popularity among users. However, this popularity has also led to an increase in reported video game addiction. There may be consumer engagement–related factors that may influence video game addiction.

Objective

This study aims to empirically examine the impact of the dimensions of consumer video game engagement on video game addiction. The dimensions are dedication, absorption, conscious attention, social connection, enthusiasm, and interaction. We utilize the uses and gratifications theory to study the video game engagement dimensions as potential factors through which gamers feel gratified and engaged in video game playing. Additionally, this study incorporates the cultivation theory to investigate how video game engagement factors trigger video game addiction.

Methods

A two-step process was applied for data analysis on valid cases of 176 gamers aged 15-25 years: video game addiction was specified and validated as a reflective-formative construct, and hypothesis testing was later performed using the WarpPLS on valid respondents.

Results

The analysis uncovered 2 dimensions of video game engagement: social connection with P=.08 and interaction with P=.49, which did not significantly contribute to video game addiction.

Conclusions

This study offers unique insights to a myriad of stakeholders, mostly psychologists and psychiatrists, who routinely prescribe behavior modification techniques to treat video game addiction.