bluuebunny/crossref_metadata_2025 huggingface dataset:
Selecting Sample Preparation Workflows for Mass Spectrometry-Based Proteomic and Phosphoproteomic Analysis of Patient Samples with Acute Myeloid Leukemia
Authors: Hernandez-Valladares Maria , Aasebø Elise , Selheim Frode , Berven Frode , Bruserud Øystein
Published: August 2016

Global mass spectrometry (MS)-based proteomic and phosphoproteomic studies of acute myeloid leukemia (AML) biomarkers represent a powerful strategy to identify and confirm proteins and their phosphorylated modifications that could be applied in diagnosis and prognosis, as a support for individual treatment regimens and selection of patients for bone marrow transplant. MS-based studies require optimal and reproducible workflows that allow a satisfactory coverage of the proteome and its modifications. Preparation of samples for global MS analysis is a crucial step and it usually requires method testing, tuning and optimization. Different proteomic workflows that have been used to prepare AML patient samples for global MS analysis usually include a standard protein in-solution digestion procedure with a urea-based lysis buffer. The enrichment of phosphopeptides from AML patient samples has previously been carried out either with immobilized metal affinity chromatography (IMAC) or metal oxide affinity chromatography (MOAC). We have recently tested several methods of sample preparation for MS analysis of the AML proteome and phosphoproteome and introduced filter-aided sample preparation (FASP) as a superior methodology for the sensitive and reproducible generation of peptides from patient samples. FASP-prepared peptides can be further fractionated or IMAC-enriched for proteome or phosphoproteome analyses. Herein, we will review both in-solution and FASP-based sample preparation workflows and encourage the use of the latter for the highest protein and phosphorylation coverage and reproducibility.
Clustering and Beamforming for Efficient Communication in Wireless Sensor Networks
Authors: Porcel-Rodríguez Francisco , Valenzuela-Valdés Juan , Padilla Pablo , Luna-Valero Francisco , Luque-Baena Rafael , López-Gordo Miguel
Published: August 2016

Energy efficiency is a critical issue for wireless sensor networks (WSNs) as sensor nodes have limited power availability. In order to address this issue, this paper tries to maximize the power efficiency in WSNs by means of the evaluation of WSN node networks and their performance when both clustering and antenna beamforming techniques are applied. In this work, four different scenarios are defined, each one considering different numbers of sensors: 50, 20, 10, five, and two nodes per scenario, and each scenario is randomly generated thirty times in order to statistically validate the results. For each experiment, two different target directions for transmission are taken into consideration in the optimization process (φ = 0° and θ = 45°; φ = 45°, and θ = 45°). Each scenario is evaluated for two different types of antennas, an ideal isotropic antenna and a conventional dipole one. In this set of experiments two types of WSN are evaluated: in the first one, all of the sensors have the same amount of power for communications purposes; in the second one, each sensor has a different amount of power for its communications purposes. The analyzed cases in this document are focused on 2D surface and 3D space for the node location. To the authors’ knowledge, this is the first time that beamforming and clustering are simultaneously applied to increase the network lifetime in WSNs.
Influence of synthesis conditions on microstructure and phase transformations of annealed Sr2FeMoO6−x nanopowders formed by the citrate–gel method
Authors: Yarmolich Marta , Kalanda Nikolai , Demyanov Sergey , Terryn Herman , Ustarroz Jon , Silibin Maksim , Gorokh Gennadii
Published: August 2016

The sequence of phase transformations during Sr2FeMoO6−x crystallization by the citrate–gel method was studied for powders synthesized with initial reagent solutions with pH values of 4, 6 and 9. Scanning electron microscopy revealed that the as-produced and annealed powders had the largest Sr2FeMoO6−x agglomerates with diameters in the range of 0.7–1.2 µm. The average grain size of the powders in the dispersion grows from 250 to 550 nm with increasing pH value. The X-ray diffraction analysis of the powders annealed at different temperatures between 770 and 1270 K showed that the composition of the initially formed Sr2FeMoO6−x changes and the molybdenum content increases with further heating. This leads to a change in the Sr2FeMoO6−x crystal lattice parameters and a contraction of the cell volume. An optimized synthesis procedure based on an initial solution of pH 4 allowed a single-phase Sr2FeMoO6−x compound to be obtained with a grain size in the range of 50–120 nm and a superstructural ordering of iron and molybdenum cations of 88%.
Fermentation kinetics and in vitro degradation rates of grasses of the genus Cynodon
Authors: Reis Sidnei Tavares dos , Lima Marcus Vinícius Gonçalves , Sales Eleuza Clarete Junqueira de , Monção Flávio Pinto , Rigueira João Paulo Sampaio , Santos Leonardo David Tuffi
Published: August 2016

The present study aimed to evaluate the fermentation kinetics and degradation rates of Cynodon grasses estimated by semi-automated technique of in vitro gas production. The forages were: Coastcross, Tifton 85 and Tifton 68. Pressure readings were taken at 0, 2, 4, 6, 8, 10, 12, 15, 19, 24, 30, 36, 48, 72 and 96 hours. Dry matter degradability (DMD) was obtained by the percentage of dry matter (DM) remaining after 0, 6, 12, 24, 48 and 96 hours of fermentation. Tifton 85 showed a higher total gas production (p <0.05). Higher fermentation rates were found at the beginning of fermentation followed by subsequent reduction (p <0.05) over time. Tifton 85 and Tifton 68 showed higher values (p < 0.05) for soluble fraction, potentially degradable insoluble fraction, insoluble fraction, potential and effective degradability of dry matter in relation to Coastcross grass. Higher gas production during in vitro incubation of dry matter was observed for Tifton 85 g.
Forage yield in pastures with bermuda grass mixed with different legumes
Authors: Anjos Amanda Nunes Assis dos , Olivo Clair Jorge , Sauter Caroline Paim , Silva Aline Rodrigues , Santos Fabiene Tomazetti dos , Seibt Daiane Cristine
Published: August 2016

Three grazing systems with Coastcross-1 bermuda grass (CC) + 100 kg N ha-1 year-1 + common vetch; CC + 100 kg N ha-1 year-1 + arrowleaf clover; and CC + 200 kg N ha-1 year-1 were evaluated. Thirteen grazing cycles were performed during the experimental period (313 days), with two, five, four and two cycles respectively in winter, spring, summer and fall. Lactating Holstein cows were used in the evaluation. Daily accumulation rate, forage production, rate of forage disappearance, agronomic intake, grazing efficiency, herbage allowance and stocking rate were evaluated. Mean rates of forage yield and stocking rate were 20.8; 17.6 and 19.7 t DM ha-1 and 7.0; 6.8 to 6.8 animal units ha-1 day-1 for the respective forage systems. The mixture Coastcross-1 plus common vetch, fertilized with 100 kg N ha-1 year-1 and Coastcross-1 fertilized with 200 kg N ha-1 year-1 provided greater productivity and better distribution of forage throughout the seasons.
Energy Consumption in Batch-Mode Capacitive Deionization
Authors: Li Hai Bo , Liang Sen , Gao Mang Mang , Kim Chang Yeoul
Published: August 2016

Capacitive deionization (CDI) is a water desalination technique in which salt ions are removed from brackish water by flowing through a spacer channel with porous electrodes on each side. Upon applying a small voltage difference between the two electrodes, cations move to and are accumulated in electrostatic double layers inside the negatively charged cathode and the anions are removed by the positively charged anode. Therefore, one of the advanced merits of CDI is the low driven energy by compared to other desalination technologies. Inspired this, we have performed the calculation on energy consumption of activated carbon based CDI in different operation conditions. The results show that the energy consumptions are significantly related to cell voltage as well as solution concentration. Furthermore, the round trip efficiency as a vital indication in terms of energy consumption have been introduced and discussed as well.
Effect of Silica on the Wettability and Composition of the Alumina/Aluminum Interface
Authors: Sang Ke Zheng , An Rui , Huang Zhi Wen , Li Hong Wei , Matsushita Jun-Ichi
Published: August 2016

In order to improve the wetting ability of metal to ceramic, silica coatings on alumina/ mullite ceramics were prepared with tetraethyl orthosilicate (TEOS) by sol-gel method. The preparation processing was optimized. Furthermore, the interactions between the aluminum melt and the ceramic with or without silica coating were investigated. The results showed that the silica coatings could be successfully prepared. The molten aluminum melt reacted with silica, and alumina was formed at the interface between ceramic and metal. The ceramic (alumina/ mullite) substrates could be infiltrated by aluminum melts due to the existence of mullite. The silica coatings conduced to the infiltration and improved the combination between the ceramic and aluminum at the interface.
Effects of Additives Content on the Properties of Porous SiC Ceramics
Authors: Li Rong , Liu Rong Zhen , Liu Gao Jian , Jin Zhi Hao
Published: August 2016

The porous silicon carbide ceramics were fabricated by adding a variety of low melting point oxides in this paper. The additives were mullite, magnesium oxide, calcium oxide, and vanadium oxide. Effects of the additives content on the properties of porous silicon carbide ceramics were studied. The results showed that, when the additives content was greater than 2.8%, the apparent porosity, the bending strength, the permeability and the pore size were in an inversely proportional relationship with the additives content, while the content was less than 2.8%, proportional relationship was observed. When the additives content reached 2.8%, the porous SiC ceramics showed the best performances.
Influencing consumer engagement in online customer communities: The role of interactivity
Authors: Mpinganjira Mercy
Published: August 2016

Purpose: The purpose of this article was to investigate consumer engagement in online customer communities and the influence of interactivity on it. A conceptual model linking different dimensions of interactivity and consumer engagement was proposed and tested.Rationale: The ability of managers to ensure high levels of consumer engagement depends on them gaining a good understanding of the concept, its manifestations in their context, as well as factors that influence it. This article aims at contributing to this understanding in the context of online customer communities.Methodology: The article followed a quantitative research approach. Data were collected from 303 members of online customer communities based in Gauteng, South Africa. Structural equation modelling was used to test the hypotheses proposed in the article.Findings and implications: The results showed that system-related dimensions of interactivity and human interactivity are positively associated with consumer psychological engagement. Psychological engagement was in turn found to be positively associated with behavioural engagement. The findings point to the need for managers to pay attention to system and human related interactivity if they are to influence consumer engagement levels on their sites.Originality and value of research: Little research exists on consumer engagement, resulting in limited understanding of the concept as well as its antecedents. Focusing on online customer communities, this article contributes to addressing this gap in literature. Managers of online customer communities can use the findings to monitor levels of consumer engagement on their sites and find ways of enhancing it.
223Ra calix[4]arene-crown ether antibody conjugates as potential radiopharmaceuticals for the treatment of cancer
Authors: Ackermann J. , Jansen D. , Jarvis N. , Muller A. , Zeevaart J-R.
Published: August 2016

No abstract available.
Rational Function Operators from Poisson Integrals
Authors: Xu Xu , Zhu Laiyi
Published: August 2016

In this paper, we construct two classes of rational function operators using the Poisson integrals of the function on the whole real axis. The convergence rates of the uniform and mean approximation of such rational function operators on the whole real axis are studied.
Two Ways to Teach: Direct Instruction and Indirect Instruction/Inquiry: Simplifying Planning Concepts for Early Career Teachers
Authors: Maynes Nancy , Hatt Blaine E.
Published: August 2016

This paper describes two planning diagrams that support pre-service and early career teachers’ understanding of direct and indirect instructional approaches to teaching Conceptual models can support understanding of the embedded decision points that new teachers must address as they plan lessons. In this paper, we offer 2 models to support the understanding of pre-service and early career teachers with two conceptual diagrams that relate to lesson planning. One of these diagrams has been used for several years with pre-service teachers who have identified that this conceptual diagram has helped them understand planning concepts early in their planning experiences. This diagram demonstrates the phases of instruction used by experienced teachers when they plan for direct instruction. A body of prior research has been completed to demonstrate the existence of the main conceptions and relative times in the diagram as they are evident in teachers’ practice and to identify how the diagram is perceived by pre-service teachers. The second diagram has been designed as a complimentary method of helping pre-service teachers understand concepts related to planning for indirect instruction involving various forms of inquiry.
The Impact of the Volume of Deposits and Facilities and Profits on Bank’s Liquidity an Exploratory Study on Jordanian Commercial Banks
Authors: AL-shawawreh Taha Barakat
Published: August 2016

Banks liquidity is the main driver of banking operations, and the lack of the sufficient liquidity prevents banks from performing their role as a mediator between money owners and funding seekers, in addition to inability to meet the costs of daily operations including employees’ salaries. And this puts the bank in a risky situation threatening the bank survival. So bank liquidity shortage has consequences damages of social and economic. Where this shortage may deprive the funding seeker from establishing a business or industrial project or etc. of projects, which may contribute in economic development in the country in the one hand, and deprive his family from gaining additional income to improve their livelihood from the other hand.

Therefore, one can find that banks have paying increased attention towards liquidity, and Central Banks Keep on liquidity ratios that banks should keep them. As long as banking deposits facilities, and profits are the actual drives of banks liquidity, this study examines in the effects of these activities on liquidity in Jordanian Commercial banks.
“Wall of Words”: Fakir Mohan Senapati, Premchand, and The Language Controversies in Late Colonial India
Authors: Satpathy Sumanyu
Published: August 2016

Linguistic controversies in one particular region of India often get treated as discrete units, as if such controversies have never had any bearing on other languages and regions in the subcontinent. I attempt a corrective to such insular approaches by juxtaposing various linguistic identity-based struggles in nineteenth-century India to demonstrate that there are several common players who operate across various linguistic zones and who are often inconsistent in their views and analyses. This essay examines the various linguistic controversies by organizing them along three broad axes with overlaps: the specialist, the instrumentalist, and the literary. The first set of controversies was conducted in jargon-ridden scholarship within newly emerged disciplinary practices such as philology, pedagogy, and linguistics. The secondary set of controversies was the concerns of intellectuals, missionaries, educationists, and scholars who were engaged in discharging juridical–administrative responsibilities. At the tertiary level, the controverters comprised the practitioners of literary culture. The essay shows how the cultural expressions within different linguistic groups inherit and share these derivative discourses while employing linguistic strategies as part of their linguistic–identitarian aesthetics. The essay, finally, argues for a need to evolve a more integrative methodology to “do” comparative literature in South Asia.
A Space For Debate: Fashioning the Urdu Novel in Colonial India
Authors: Dubrow Jennifer
Published: August 2016

The novel emerged in South Asia not as an import from Europe, but rather as the product of multiple sources and as a genre capable of fulfilling a distinct function. I argue that the novel as a genre arose in colonial India because of its ability to hold divergent points of view and to subtly critique the British government. I focus on two early Urdu novels, Nazir Ahmad's Mirāt ul-'Arūs (1869) (The Bride's Mirror) and Ratan Nath Sarshar's Fasāna-e Āzād (1878–1883) (The Tale of Azad), to examine how novelists used techniques such as the contrasting character pair to explore irreconcilable problems under colonial rule. I uncover how Fasāna-e Āzād drew from the earlier Indo-Persian and Urdu genre of the romance (dāstān) in its use of contrasting character pairs, reimagining the technique to carve out a space for debate and critique in the novel. This strategy represents one of the ways that early vernacular-language novelists fashioned the novel genre as a form uniquely suited to engaging with the challenges and contradictions of the colonial period.
Dialectics and Caste: Rethinking Dalit Life-Writings in the Vernacular, Comparing Dalit Narratives
Authors: Chatterjee Sreya
Published: August 2016

Caste has emerged as one of contemporary India's most explosive issues, with the advent of majoritarian nationalism along with neoliberal globalization. While Indian English writing with its focus on the middle-class, upper-caste citizen-subject has garnered substantial attention in the global literary market, Dalit literature, especially in the vernacular languages has remained in the shadows. The representation of “personhood” in Dalit “life-writing” offers an effective counterpoint to dominant Anglophone or postcolonial cultural production. I explore Marathi writer Laxman Gaikwad's Uchlaya (1987) (The Branded [1998]) and the more recently published Manoranjan Byapari's Bengali-language Itibritte Chandal Jiban (2013) (History of a Corpse-Handler's Life) as narratives of Dalit self-articulation that mount a formal and thematic critique of nationalist culture and its male, upper-caste, normative subject.
Reviewer Acknowledgements for International Journal of Psychological Studies, Vol. 8, No. 3
Authors: Sun Barbara
Published: August 2016

Reviewer Acknowledgements for International Journal of Psychological Studies, Vol. 8, No. 3, 2016
Reviewer Acknowledgements for Journal of Education and Learning, Vol. 5, No. 3
Authors: Sun Barbara
Published: August 2016

Reviewer Acknowledgements for Journal of Education and Learning, Vol. 5, No. 3, 2016
EGFr, FGFr and PDGFr: Emerging Targets for Anticancer Drug Design
Authors: Sisir Nandi  , Manish C. Bagchi
Published: August 2016

Number of cancer affected individuals are increasing day by each year, 11 million people are diagnosed with cancer out of which 7.6 million people die of this deadly disease which is a very significant figure in worldwide mortality. It has been estimated that there will be 16 million new cancer cases every year by 2020. Despite tremendous chemotherapeutics are given to treat cancer toxicity appears to be the most seminal point which can kill normal body cells along with abnormal cancerous cells. Therefore, researchers have been devoted to discover less toxic new chemotherapeutics which can prevent damage to the normal tissues. Recent advancements in molecular biology of cancer and different pathways involved in malignant transformation of cells clearly demonstrate that one of the important mechanisms for progression of cancer is abnormal signal transduction via tyrosine protein kinase. Tyrosine kinase catalyzes phosphorylation of tyrosine residues in proteins. The phosphorylation of protein residue results into the functions of protein. Tyrosine kinase function in many signal transduction cascades wherein extracellular signal is transmitted through the cell membrane receptors (EGFr/FGFr/PDGFr/C-src) to the nucleus where gene encoding this receptor protein maybe modified by this signal. Mutation of gene may causes abnormal signal transduction and leads to the progression of cancer. Therefore EGFr, FGFr and PDGFr have become the emerging targets for development of promising anticancer leads having lower toxicity. The present review is an attempt in this direction dealing with various aspects of cancer, molecular pharmacology of EGFr, FGFr and PDGFr tyrosine protein kinases which has a direct bearing on the design and development of newer chemotherapeutics.
Uticaj zamora na akustičke karakteristike glasa kod vokalnih profesionalaca
Authors: Šehović Ivana
Published: August 2016

Uvod. Problemi sa glasom kod vokalnih profesionalaca povezani su sa kontinuiranomvokalnom produkcijom, a to dovodi do vokalnog zamora. Vokalnizamor se odražava na akustičke karakteristike glasa i dovodi do promenaakustičkog kvaliteta tokom vokalne produkcije. Cilj ovog rada bio je da seispitaju akustičke karakteristike glasa kod vokalnih profesionalaca.Metode. Istraživanje je sprovedeno na uzorku od 45 ispitanica, koje su pozanimanju bile nastavnice, starosti 27– 62 godine. Akustički parametri kojisu praćeni pre i posle vokalnog zamora bili su: prosečna fundamentalnafrekvencija (Fo), varijacije u visini fundamentalne frekvencije (Jitt), varijacijeu amplitudi osnovnog laringealnog tona (Shim), parametar procene šumai tremora (NHR). U istraživanju je korišćena Kompjuterska laboratorija zaanalizu glasa. U obradi podataka korišćen je statistički paket SPSS 20.0.Rezultati. Dobijeni rezultati su pokazali da postoji statistički značajna povezanostizmeđu akustičkih parametara Fo (p<0,05), Jitt (p<0,05) i NHR (p<0,05)pre vokalnog zamora i vrednosti istih parametara zabeleženih posle vokalnogzamora. Nije utvrđena statistički značajna razlika u vrednostima merenihparametara glasa na početku i na kraju radne nedelje.Zaključak. Istraživanje je pokazalo da profesionalno korišćenje glasa kodnastavnika može dovesti do kumulacije zamora koji ugrožava glasovnu performansuod početka do kraja radne nedelje. Dobra vokalna tehnika i pravilnaklasifikacija glasa su preduslovi za optimalnu fonaciju i dugu vokalnu karijeru.
Specifičnost i senzitivnost biomarkera balkanske endemske nefropatije
Authors: Marić Slobodan
Published: August 2016

Uvod. Posljednjih godina posvećuje se posebna pažnja definisanju kriterijumaza dijagnozu balkanske endemske nefropatije (BEN). Cilj rada je ispitivanjesenzitivnosti, specifičnosti i graničnih vrijednosti biomarkera koji se koristeza dijagnozu BEN.Metode. Ispitivanje je obuhvatilo 103 odrasle osobe podijeljene u dvije grupe:1. grupa od 60 bolesnika sa BEN (35 muškaraca, starosti od 48 do 82 godine)i 2. grupa od 43 zdrave osobe (23 muškarca, starosti od 23 do 78 godina).Svim ispitanicima je pored detaljne anamneze urađen objektivni pregled,laboratorijske analize seruma i urina, i pregled bubrega ultrazvukom. Poredrutinskih laboratorijskih analiza urađeno je i mjerenje koncentracije albumina,alfa1-mikroglobulina i KIM-1 u urinu.Rezultati. Bolesnici sa BEN bili su značajno stariji, imali značajno viši sistolnii srednji krvni pritisak, nižu koncentraciju hemoglobina, manju jačinuglomerulske filtracije (JGF) i tubulsku reapsorpciju fosfata od zdravih osoba.Izlučivanje alfa1-mikroglobina (2,56 mg/mmol kreatinina vs. 0,09 mg/mmolkreatinina; p=0,004), albumina (6,5 mg/mmol kreatinina vs. 1,87 mg/mmolkreatinina; p=0,018) i proteina (26,7 mg/mmol kreatinina vs. 11,5 mg/mmolkreatinina; p<0,0001) urinom bilo je značajno veće kod bolesnika sa BEN negokod zdravih osoba. Nije utvrđena statistički značajna razlika u ekskreciji KIM-1između dvije grupe. Dužina bubrega je bila značajno manja kod bolesnika saBEN nego kod zdravih osoba (97,8 mm vs.105,8 mm). Alfa1-mikroglobulin uurinu ima najveću specifičnost (100%) i senzitivnost (81,1%) (granična vrijednost:1,08 mg/mmol kreatinina) za razlikovanje BEN od zdravih. Logističkaregresiona analiza je izdvojila proteinuriju i JGF kao značajne prediktore zadijagnozu BEN.Zaključak. Alfa1-mikroglobulin u urinu ima pri graničnoj vrijednosti od 1,08mg/mmol kreatinina visoku senzitivnost i specifičnost za razlikovanje BENod zdravih osoba, pa se može smatrati optimalnim testom za dijagnozu BEN.
Gluteal compartment syndrome caused by traumatic rupture of the superior gluteal artery
Authors: Omerović Djemil , Gavrankapetanović Ismet , Gavrankapetanović Faris , Hadžimehmedagić Amel , Lazović Faruk , Ahmetović Amir
Published: August 2016

Introduction. We report a case of a sixty-year-old man diagnosed with glutealcompartment syndrome caused by traumatic rupture of the superior glutealartery associated with fracture of the inferior pubic ramus and blunt trauma.Case report. A patient was injured falling from a height of four meters. Signsof compartment syndrome and sciatic nerve compression developed threehours after the injury. The patient went through a computerized tomography(CT) scan procedure with contrast, which showed a hematoma in the glutealregion, but without signs of active bleeding. However, after observation andmonitoring of the patient, CT angiography was performed which revealeda rupture of the superior gluteal artery. Fasciotomy and debridement wereperformed and the patient was diagnosed with gluteal compartment syndromeand rupture of the superior gluteal artery. Surgery resulted in a significantimprovement of the patient’s condition.Conclusion. Traumatic gluteal compartment syndrome is a rare condition.Gluteal compartment syndrome should be taken into consideration in eachpatient with pelvic trauma and hematoma in the gluteal region whose neurologicalstatus is affected. Prompt diagnosis and fasciotomy are crucial inthe treatment and fasciotomy presents the gold standard in the treatment.
Faktori koji utiču na ishod liječenja sindroma kaude ekvine
Authors: Bajić Zorislava , Nalesnik Milada , Boškić Tatjana , Jovanović Biljana
Published: August 2016

Uvod. Grupa znakova i simptoma koji se javljaju kao rezultat oštećenja nervnihkorjenova caudae equinae smještenih u kičmenom kanalu nosi naziv sindromkaude ekvine (cauda equina syndrome). Najčešće je uzrokovana lumbalnomhernijacijom intervertebralnog diska. Klinička slika se karakteriše bolom ukrsnom, glutealnom i perinealnom regionu, bolom duž zadnje strane donjegekstremiteta, utrnulošću i motornim i senzornim deficitima na donjim ekstremitetima.Može se javiti i disfunkcija mokraćne bešike i potencije.Prikaz bolesnika. Pacijent dolazi na pregled kod fizijatra zbog jakog bola uslabinskom segmentu, koji se propagirao duž oba donja ekstremiteta praćenosjećajem slabosti, više lijevo, te nemogućnosti pražnjenja mokraćne bešike.Snimak dobijen nuklearnom magnetnom rezonancom (NMR) pokazujeprotruziju intravertebralnog diska na dva nivoa. Pacijent je podvrgnut operativnomzahvatu: Hemilaminectomia L4 l. sin et foraminotomia L5-S1 l. sin,extirpatio disci. Mjesec dana nakon operativnog zahvata provodi postoperativnustacionarnu rehabilitaciju. Na prijemu je detektovana slabost plantarnihfleksora lijevog stopala, te trnjenje u istom, nepotpuno pražnjenje bešike,nemogućnost kontrole spoljašnjeg analnog sfinktera i disfunkcija potencije.Nalaz urofloumetrije potvrdio je tešku hipotoniju detrusora mokraćne bešikekoja graniči sa atonijom. Pacijent je proveo fizikalni tretman, te dva ciklusaelektrostimulacije detrusora mokraćne bešike. Kontrolni urodinamski nalazbez značajnijih promjena u odnosu na prethodni. Nakon provedenog liječenjapacijent ima osjećaj olakšanog mokrenja, seksualna disfunkcija je manjа, snagaplantarnih fleksora je poboljšana.Zaključak. Na samom početku liječenja bili su prisutni faktori koji su ukazivalina teškoće u ishodu liječenja (hronični bol, odloženo operativno liječenje,odložena rehabilitacija). Smatramo da je poboljšanje nastupilo kao posljedicapsihološkog stanja pacijenta koji uspijeva uticati na aktivnosti sfinktera.
The impact of pyrethroid resistance on the efficacy and effectiveness of bednets for malaria control in Africa
Authors: Churcher Thomas S , Lissenden Natalie , Griffin Jamie T , Worrall Eve , Ranson Hilary
Published: August 2016

Long lasting pyrethroid treated bednets are the most important tool for preventing malaria. Pyrethroid resistant Anopheline mosquitoes are now ubiquitous in Africa, though the public health impact remains unclear, impeding the deployment of more expensive nets. Meta-analyses of bioassay studies and experimental hut trials are used to characterise how pyrethroid resistance changes the efficacy of standard bednets, and those containing the synergist piperonyl butoxide (PBO), and assess its impact on malaria control. New bednets provide substantial personal protection until high levels of resistance, though protection may wane faster against more resistant mosquito populations as nets age. Transmission dynamics models indicate that even low levels of resistance would increase the incidence of malaria due to reduced mosquito mortality and lower overall community protection over the life-time of the net. Switching to PBO bednets could avert up to 0.5 clinical cases per person per year in some resistance scenarios.
Managing contamination delay to improve Timing Speculation architectures
Authors: Avirneni Naga Durga Prasad , Ramesh Prem Kumar , Somani Arun K.
Published: August 2016

Timing Speculation (TS) is a widely known method for realizing better-than-worst-case systems. Aggressive clocking, realizable by TS, enable systems to operate beyond specified safe frequency limits to effectively exploit the data dependent circuit delay. However, the range of aggressive clocking for performance enhancement under TS is restricted by short paths. In this paper, we show that increasing the lengths of short paths of the circuit increases the effectiveness of TS, leading to performance improvement. Also, we propose an algorithm to efficiently add delay buffers to selected short paths while keeping down the area penalty. We present our algorithm results for ISCAS-85 suite and show that it is possible to increase the circuit contamination delay by up to 30% without affecting the propagation delay. We also explore the possibility of increasing short path delays further by relaxing the constraint on propagation delay and analyze the performance impact.
Iterative guided image fusion
Authors: Toet Alexander
Published: August 2016

We propose a multi-scale image fusion scheme based on guided filtering. Guided filtering can effectively reduce noise while preserving detail boundaries. When applied in an iterative mode, guided filtering selectively eliminates small scale details while restoring larger scale edges. The proposed multi-scale image fusion scheme achieves spatial consistency by using guided filtering both at the decomposition and at the recombination stage of the multi-scale fusion process. First, size-selective iterative guided filtering is applied to decompose the source images into approximation and residual layers at multiple spatial scales. Then, frequency-tuned filtering is used to compute saliency maps at successive spatial scales. Next, at each spatial scale binary weighting maps are obtained as the pixelwise maximum of corresponding source saliency maps. Guided filtering of the binary weighting maps with their corresponding source images as guidance images serves to reduce noise and to restore spatial consistency. The final fused image is obtained as the weighted recombination of the individual residual layers and the mean of the approximation layers at the coarsest spatial scale. Application to multiband visual (intensified) and thermal infrared imagery demonstrates that the proposed method obtains state-of-the-art performance for the fusion of multispectral nightvision images. The method has a simple implementation and is computationally efficient.
Identification of multi‐copy suppressors for endoplasmic reticulum‐mitochondria tethering proteins in Saccharomyces cerevisiae
Authors: Kojima Rieko , Kajiura Shu , Sesaki Hiromi , Endo Toshiya , Tamura Yasushi
Published: August 2016

In yeast, the endoplasmic reticulum (ER)‐mitochondria encounter structure (ERMES) tethers the ER to mitochondria, but its primary function remains unclear. To gain insight into ERMES functions, we screened multi‐copy suppressors of the growth‐defective phenotype of mmm1∆ cells, which lack a core component of ERMES, and identified MCP1, MGA2, SPT23, and YGR250C (termed RIE1). Spt23 and Mga2 are homologous transcription factors known to activate transcription of the OLE1 gene, which encodes the fatty acid ∆9 desaturase. We found that Ole1 partially relieves the growth defects of ERMES‐lacking cells, thus uncovering a relationship between fatty acid metabolism and ERMES functions.
A clamp‐like orientation of basic residues set in a parallelogram is essential for heparin binding
Authors: Cheng Yi‐Yun , Cheng Chao‐Sheng , Lee Tian‐Ren , Chang Wun‐Shaing Wayne , Lyu Ping‐Chiang
Published: August 2016

While the majority of studies have focused on the biological roles of heparin‐binding proteins, relatively little is known about their key residues and structural elements responsible for heparin interaction. In this study, we employed the IgG‐binding domain B1 of Streptococcal protein G as a miniature scaffold to investigate how certain positively charged residues within the β‐sheet conformation become favorable for heparin binding. By performing a series of arginine substitution mutations followed by gain‐of‐heparin‐binding analysis, we deduced that a clamp‐like orientation with discontinuous basic residues separated by ~ 5 Å with ~ 100° interior angle is advantageous for high heparin affinity.
The effect of channel deepening on tides and storm surge: A case study of Wilmington, NC
Authors: Familkhalili R. , Talke S. A.
Published: August 2016

In this study we investigate the hypothesis that increasing channel depth in estuaries can amplify both tides and storm surge by developing an idealized numerical model representing the 1888, 1975, and 2015 bathymetric conditions of the Cape Fear River Estuary, NC. Archival tide gauge data recovered from the U.S. National Archives indicates that mean tidal range in Wilmington has doubled to 1.55 m since the 1880s, with a much smaller increase of 0.07 m observed near the ocean boundary. These tidal changes are reproduced by simulating channel depths of 7 m (1888 condition) and 15.5 m (modern condition). Similarly, model sensitivity studies using idealized, parametric tropical cyclones suggest that the storm surge in the worst‐case, CAT‐5 event may have increased from 3.8 ± 0.25 m to 5.6 ± 0.6 m since the nineteenth century. The amplification in both tides and storm surge is influenced by reduced hydraulic drag caused by greater mean depths.
Deformation and faulting of subduction overriding plate caused by a subducted seamount
Authors: Ding Min , Lin Jian
Published: August 2016

We conducted numerical experiments to simulate elastoplastic deformation of the overriding plate caused by a subducted seamount. Calculations revealed development of a distinct pair of fault‐like shear zones, including a landward dipping forethrust fault initiated from the seamount top and a seaward dipping backthrust fault from the landward base of the seamount. Significant dome‐shaped surface uplift was predicted above the thrust faults. Lesser‐developed seaward dipping backthrust faults were calculated to develop under certain conditions. The overriding plate was calculated to deform in two stages: In Stage I, elastic deformation leads to the formation of fault‐like shear zones. After major faults have cut through the entire plate, plastic deformation on faults dominates Stage II. On the subduction interface, compressional normal stress was calculated to increase on the landward leading flank of the seamount and decrease on the seaward trailing flank. These changes, together with associated stress singularities at seamount edges, could affect earthquake processes.
Magnetic reconnection at the dayside magnetopause: Advances with MMS
Authors: Burch J. L. , Phan T. D.
Published: August 2016

Magnetic reconnection is known to be an important process for coupling solar wind mass and momentum into the Earth's magnetosphere. Reconnection is initiated in an electron‐scale dissipation/diffusion region around an X line, but its consequences are large scale. While past experimental efforts have advanced our understanding of ion‐scale physics and the consequences of magnetic reconnection, much higher spatial and temporal resolutions are needed to understand the electron‐scale processes that cause reconnection. The Magnetospheric Multiscale (MMS) mission was implemented to probe the electron scale of reconnection. This article reports on results from the first scan of the dayside magnetopause with MMS. Specifically, we introduce a new event involving the radial traversal of guide‐field reconnection to illustrate features of reconnection physics on the electron scale.
The record‐breaking 2015 hurricane season in the eastern North Pacific: An analysis of environmental conditions
Authors: Collins Jennifer M. , Klotzbach Philip J. , Maue Ryan N. , Roache David R. , Blake Eric S. , Paxton Charles H. , Mehta Christopher A.
Published: August 2016

The presence of a near‐record El Niño and a positive Pacific Meridional Mode provided an extraordinarily warm background state that fueled the 2015 eastern North Pacific hurricane season to near‐record levels. We find that the western portion of the eastern North Pacific, referred to as the Western Development Region (WDR; 10°–20°N, 116°W–180°), set records for named storms, hurricane days, and Accumulated Cyclone Energy in 2015. When analyzing large‐scale environmental conditions, we show that record warm sea surface temperatures, high midlevel relative humidity, high low‐level relative vorticity, and record low vertical wind shear were among the environmental forcing factors contributing to the observed tropical cyclone activity. We assess how intraseasonal atmospheric variability may have contributed to active and inactive periods observed during the 2015 hurricane season. We document that, historically, active seasons are associated with May–June El Niño conditions, potentially allowing for predictability of future active WDR seasons.
Current distribution in a rectangular flow channel manufactured by 3‐D printing
Authors: Figueredo‐Rodríguez Horacio A. , McKerracher Rachel D. , Ponce de León Carlos , Walsh Frank C.
Published: August 2016

The characterization and improvement of a rectangular channel electrolyte flow compartment used in an iron‐air flow battery was carried out by using an arrangement of copper electrodes to measure the current density distribution employing the limiting current technique. The present work addresses the hydrodynamics and mass transport distribution in the compartment and their improvement by an improved electrolyte compartment that results in a more uniform current distribution. The current distribution was evaluated as the ratio between the local and the averaged limiting current densities during the reduction of copper ions over a range of mean linear flow velocity across the electrode surface (2–30 cm s−1). The initial compartment, showed larger differences between the minimum and maximum currents than the electrolyte compartment that resulted as part of the design process and showed a higher pressure drop at a given mean linear flow velocity. © 2016 American Institute of Chemical Engineers AIChE J, 63: 1144–1151, 2017
Traumatic Stress Among Seriously Delinquent Youth: Considering the Consequences of Neighborhood Circumstance
Authors: Jaggers Jeremiah W. , Prattini Robert J. , Church Wesley T.
Published: August 2016

Myriad factors have been found to have an impact on delinquent behavior and traumatic stress. This study proposes a model that tests the relationship between common predictors of delinquency (neighborhood condition, antisocial peer socialization, and exposure to violence) with traumatic stress. Serial mediation was used to test the relationships between these predictors and traumatic stress. Results indicate the mediation effect between neighborhood conditions and traumatic stress significantly reduces the total effect. Implications for traumatic stress in the context of delinquent behavior are discussed.
Long‐term bosutinib for chronic phase chronic myeloid leukemia after failure of imatinib plus dasatinib and/or nilotinib
Authors: Cortes Jorge E. , Khoury Hanna J. , Kantarjian Hagop M. , Lipton Jeff H. , Kim Dong‐Wook , Schafhausen Philippe , Matczak Ewa , Leip Eric , Noonan Kay , Brümmendorf Tim H. , Gambacorti‐Passerini Carlo
Published: August 2016

Bosutinib is an Src/Abl tyrosine kinase inhibitor (TKI) indicated for adults with Ph+ chronic myeloid leukemia (CML) resistant/intolerant to prior TKIs. This long‐term update of an ongoing phase 1/2 study evaluated the efficacy and safety of third‐/fourth‐line bosutinib in adults with chronic phase (CP) CML. Median durations of treatment and follow‐up were 8.6 (range, 0.2–87.7) months and 32.7 (0.3–93.3) months, respectively. Cumulative confirmed complete hematologic response (cCHR) and major cytogenetic response (MCyR) rates were 74% (95% CI, 65–81%) and 40% (31–50%), respectively; Kaplan–Meier (K–M) probability of maintaining cCHR or MCyR at 4 years was 63% (95% CI, 50–73%) and 69% (52–81%). Cumulative incidence of on‐treatment disease progression (PD)/death at 4 years was 24% (95% CI, 17–33%); K–M 4‐year overall survival was 78% (68–85%). Baseline Ph+ cells ≤35 vs. ≥95% was prognostic of MCyR and CCyR by 3 and 6 months, increased baseline basophils was prognostic of PD/death, and no prior response to second‐line TKI was prognostic of death. Common adverse events included diarrhea (83%), nausea (48%), vomiting (38%), and thrombocytopenia (39%). Bosutinib demonstrates durable efficacy and a toxicity profile similar to previous bosutinib studies in CP CML patients resistant/intolerant to multiple TKIs, representing an important treatment option for patients in this setting. This trial is registered at www.clinicaltrials.gov (NCT00261846). Am. J. Hematol. 91:1206–1214, 2016. © 2017 The Authors American Journal of Hematology Published by Wiley Periodicals, Inc.
GAD1 gene polymorphisms are associated with hyperactivity in Attention‐Deficit/Hyperactivity Disorder
Authors: Bruxel Estela M. , Akutagava‐Martins Glaucia C. , Salatino‐Oliveira Angélica , Genro Julia P. , Zeni Cristian P. , Polanczyk Guilherme V. , Chazan Rodrigo , Schmitz Marcelo , Rohde Luis A. , Hutz Mara H.
Published: August 2016

Attention‐Deficit/Hyperactivity Disorder (ADHD) is one of the most common neurodevelopmental disorders of childhood. Recent studies suggest a role for γ‐aminobutyric acid (GABA) on ADHD hyperactive/impulsive symptoms due to behavioral disinhibition resulting from inappropriate modulation of both glutamatergic and GABAergic signaling. The glutamic acid decarboxylase (GAD1) gene encodes a key enzyme of GABA biosynthesis. The aim of the present study was to investigate the possible influence of GAD1 SNPs rs3749034 and rs11542313 on ADHD susceptibility. The clinical sample consisted of 547 families with ADHD probands recruited at the ADHD Outpatient Clinics from Hospital de Clínicas de Porto Alegre. Hyperactive/impulsive symptoms were evaluated based on parent reports from the Swanson, Nolan, and Pelham Scale—version IV (SNAP‐IV). The C allele of rs11542313 was significantly overtransmitted from parents to ADHD probands (P = 0.02). Hyperactive/impulsive score was higher in rs3749034G allele (P = 0.005, Cohen's D = 0.19) and rs11542313C allele (P = 0.03; Cohen's D = 0.16) carriers. GAD1 haplotypes were also associated with higher hyperactive/impulsive scores in ADHD youths (global P‐value = 0.01). In the specific haplotype test, the GC haplotype was the one with the highest hyperactive/impulsive scores (P = 0.03). Our results suggest that the GAD1 gene is associated with ADHD susceptibility, contributing particularly to the hyperactive/impulsive symptom domain. © 2016 Wiley Periodicals, Inc.
Middle turbinate edema as a diagnostic marker of inhalant allergy
Authors: Hamizan Aneeza W. , Christensen Jenna M. , Ebenzer Jareen , Oakley Gretchen , Tattersall Jessica , Sacks Raymond , Harvey Richard J.
Published: August 2016

Background

Middle turbinate edema could be a characteristic feature of aeroallergen sensitization. In this study we sought to determine the diagnostic characteristics of middle turbinate edema as a marker of inhalant allergy.

Methods

A cross‐sectional diagnostic study was performed on patients who had undergone nasal endoscopy and allergy testing. Allergy status was determined by positive serology or epicutaneous testing. Endoscopy was reviewed by blinded assessors for middle turbinate head edema. Appearance was graded as either normal, focal, multifocal, diffuse, or polypoid edema. Receiver‐operator (ROC) analysis, likelihood ratio (LR), sensitivity, specificity, and positive predictive value (PPV) were determined.

Results

One hundred eighty‐seven patients representing 304 nasal cavities were assessed (42% female, age 39.74 ± 14.7 years, 57% allergic). Diffuse edema (PPV 91.7%/LR = 8) and polypoid edema (PPV 88.9%/LR = 6.2) demonstrated the strongest association with inhalant allergy. Multifocal edema was used as a cut‐off to represent inhalant allergy from ROC analysis, which demonstrated 94.7% specificity and 23.4% sensitivity. The PPV for multifocal was 85.1% and LR = 4.4.

Conclusion

Middle turbinate edema is a useful nasal endoscopic feature to predict presence of inhalant allergy and, although not sensitive, has excellent PPV.
CuxCo1−xO Nanoparticles on Graphene Oxide as A Synergistic Catalyst for High‐Efficiency Hydrolysis of Ammonia–Borane
Authors: Feng Kun , Zhong Jun , Zhao Binhua , Zhang Hui , Xu Lai , Sun Xuhui , Lee Shuit‐Tong
Published: August 2016

Ammonia–borane (AB) is an excellent material for chemical storage of hydrogen. However, the practical utilization of AB for production of hydrogen is hindered by the need of expensive noble metal‐based catalysts. Here, we report CuxCo1−xO nanoparticles (NPs) facilely deposited on graphene oxide (GO) as a low‐cost and high‐performance catalyst for the hydrolysis of AB. This hybrid catalyst exhibits an initial total turnover frequency (TOF) value of 70.0 (H2) mol/(Cat‐metal) mol⋅min, which is the highest TOF ever reported for noble metal‐free catalysts, and a good stability keeping 94 % activity after 5 cycles. Synchrotron radiation‐based X‐ray absorption spectroscopy (XAS) investigations suggested that the high catalytic performance could be attributed to the interfacial interaction between CuxCo1−xO NPs and GO. Moreover, the catalytic hydrolysis mechanism was studied by in situ XAS experiments for the first time, which reveal a significant water adsorption on the catalyst and clearly confirm the interaction between AB and the catalyst during hydrolysis.