bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular mechanism of synovial joint site specification and induction in developing vertebrate limbs
Authors: Yadav Upendra S. , Biswas Tathagata , Singh Pratik N. , Gupta Pankaj , Chakraborty Soura , Delgado Irene , Zafar Hamim , Capellini Terence D. , Torres Miguel , Bandyopadhyay Amitabha
Published: June 2023

The vertebrate appendage comprises three primary segments, the stylopod, zeugopod and autopod, each separated by joints. The molecular mechanisms governing the specification of joint sites, which define segment lengths and thereby limb architecture, remain largely unknown. Existing literature suggests that reciprocal gradients of retinoic acid (RA) and fibroblast growth factor (FGF) signaling define the expression domains of the putative segment markers Meis1, Hoxa11 and Hoxa13. Barx1 is expressed in the presumptive joint sites. Our data demonstrate that RA-FGF signaling gradients define the expression domain of Barx1 in the first presumptive joint site. When misexpressed, Barx1 induces ectopic interzone-like structures, and its loss of function partially blocks interzone development. Simultaneous perturbations of RA-FGF signaling gradients result in predictable shifts of Barx1 expression domains along the proximo-distal axis and, consequently, in the formation of repositioned joints. Our data suggest that during early limb bud development in chick, Meis1 and Hoxa11 expression domains are overlapping, whereas the Barx1 expression domain resides within the Hoxa11 expression domain. However, once the interzone is formed, the expression domains are refined and the Barx1 expression domain becomes congruent with the border of these two putative segment markers.
Strategies of epithelial repair: Modulation of stem cell and transit amplifying cell proliferation
Authors: Lehrer Michael S. , Sun Tung-Tien , Lavker Robert M.
Published: June 2023

Using double labeling techniques, we studied the replication of corneal epithelial stem cells that reside exclusively in the limbal zone, and their progeny transit amplifying cells. We show that corneal epithelial stem cells can be induced to enter DNA synthesis by wounding and by TPA. We demonstrate the existence of a hierarchy of TA cells; those of peripheral cornea undergo at least two rounds of DNA synthesis before they become post-mitotic, whereas those of central cornea are capable of only one round of division. However, the cell cycle time of these TA cells can be shortened and the number of times these TA cells can replicate is increased in response to wounding. These results thus demonstrate three strategies of epithelial repair: (i) stem cell replication, (ii) the unleashing of additional rounds of cell proliferation that remain as an untapped reserve under normal circumstances, and (iii) enhancement of TA cell proliferation via a shortening of the cycling time.
Intracellular trafficking of the vacuolar H+-ATPase accessory subunit Ac45
Authors: Jansen Eric J. R. , Holthuis Joost C. M. , McGrouther Collette , Burbach J. Peter H. , Martens Gerard J. M.
Published: June 2023

Ac45 is a type I transmembrane protein associated with vacuolar H+-ATPase, a proton pump mediating the acidification of multiple intracellular organelles. In this study, we examined the intracellular routing of Ac45 in transfected CV-1 fibroblasts. Steady state immunolabeling showed that Ac45 is located on the plasma membrane and in a vacuolar compartment in the juxtanuclear region. Antibody internalization experiments revealed that Ac45 is rapidly retrieved from the cell surface and is targeted to the vacuolar structures. The 26-residue cytoplasmic tail of Ac45 was intrinsically capable of mediating endocytosis of the cell surface protein Tac, indicating that the tail contains an autonomous internalization signal. Immunolocalization studies on cells expressing carboxy-terminally truncated Ac45 mutants showed the presence of essential routing information in the membrane-distal region of the cytoplasmic tail. Further mutational analysis of this region, which lacks the recognized tyrosine- or di-leucine-based sorting motifs, suggested that multiple sites rather than a short linear sequence are responsible for the internalization. Collectively, our results indicate that the cytoplasmic tail of Ac45 contains autonomous targeting information distinct from previously described routing determinants.
The role of the Ran GTPase in nuclear assembly and DNA replication: Characterisation of the effects of Ran mutants
Authors: Hughes Mike , Zhang Chuanmao , Avis Johanna M. , Hutchison Christopher J. , Clarke Paul R.
Published: June 2023

The Ran GTPase plays a critical role in nucleocytoplasmic transport and has been implicated in the maintenance of nuclear structure and cell cycle control. Here, we have investigated its role in nuclear assembly and DNA replication using recombinant wild-type and mutant Ran proteins added to a cell-free system of Xenopus egg extracts. RanQ69L and RanT24N prevent lamina assembly, PCNA accumulation and DNA replication. These effects may be due to the disruption of nucleocytoplasmic transport, since both mutants inhibit nuclear import of a protein carrying a nuclear localisation signal (NLS). RanQ69L, which is deficient in GTPase activity, sequesters importins in stable complexes that are unable to support the docking of NLS-proteins at the nuclear pore complex (NPC). RanT24N, in contrast to wild-type Ran-GDP, interacts only weakly with importin α and nucleoporins, and not at all with the import factor p10, consistent with its poor activity in nuclear import. However, RanT24N does interact stably with importin β, Ran binding protein 1 and RCC1, an exchange factor for Ran. We show that Ran-GDP is essential for proper nuclear assembly and DNA replication, the requirement being primarily before the initiation of DNA replication. Ran-GDP therefore mediates the active transport of necessary factors or otherwise controls the onset of S-phase in this system.
VE-cadherin and desmoplakin are assembled into dermal microvascular endothelial intercellular junctions: A pivotal role for plakoglobin in the recruitment of desmoplakin to intercellular junctions
Authors: Kowalczyk Andrew P. , Navarro Pilar , Dejana Elisabetta , Bornslaeger Elayne A. , Green Kathleen J. , Kopp Daniel S. , Borgwardt Jeffrey E.
Published: June 2023

Vascular endothelial cells assemble adhesive intercellular junctions comprising a unique cadherin, VE-cadherin, which is coupled to the actin cytoskeleton through cytoplasmic interactions with plakoglobin, β-catenin and α-catenin. However, the potential linkage between VE-cadherin and the vimentin intermediate filament cytoskeleton is not well characterized. Recent evidence indicates that lymphatic and vascular endothelial cells express desmoplakin, a cytoplasmic desmosomal protein that attaches intermediate filaments to the plasma membrane in epithelial cells. In the present study, desmoplakin was localized to intercellular junctions in human dermal microvascular endothelial cells. To determine if VE-cadherin could associate with desmoplakin, VE-cadherin, plakoglobin, and a desmoplakin amino-terminal polypeptide (DP-NTP) were co-expressed in L-cell fibroblasts. In the presence of VE-cadherin, both plakoglobin and DP-NTP were recruited to cell-cell borders. Interestingly, β-catenin could not substitute for plakoglobin in the recruitment of DP-NTP to cell borders, and DP-NTP bound to plakoglobin but not β-catenin in the yeast two-hybrid system. In addition, DP-NTP colocalized at cell-cell borders with α-catenin in the L-cell lines, and endogenous desmoplakin and α-catenin colocalized in cultured dermal microvascular endothelial cells. This is in striking contrast to epithelial cells, where desmoplakin and α-catenin are restricted to desmosomes and adherens junctions, respectively. These results suggest that endothelial cells assemble unique junctional complexes that couple VE-cadherin to both the actin and intermediate filament cytoskeleton.
Open Science Training in TRIPLE
Authors: Provost Lottie , Di Donato Francesca , Tóth-Czifra Erzsébet , Dumouchel Suzanne , Blotière Emilie , Chen Yin
Published: June 2023

This case study focuses on the online training activities on Open Science delivered within the H2020 project Transforming Research through Innovative Practices for Linked Interdisciplinary Exploration (TRIPLE, Grant Agreement 863420). The project is dedicated to building a discovery platform for the Social Sciences and Humanities (SSH) and is committed to promoting and supporting the uptake of Open Science within research practices.

In order to address SSH research and training communities’ needs for enhanced competencies on Open Science and for stronger support in the Findable, Accessible, Interoperable, Reusable (FAIR) management of digital training materials, two reusable outputs were produced. The work carried out is presented as a novel approach to tackle the issues related to FAIRifying research and training practices and to create training resources whose reusability and relevance reaches beyond the project lifetime and framework. The case study presents the methods by which the results were produced so as to encourage and enable their future adaptation and reuse.

The TRIPLE Open Science training series (result 1) targets SSH researchers, research support personnel and infrastructure developers in need of practical tools and specific skills to integrate Open Science practices in their workflows. The training series provides 12 competence-oriented online training events in Open Access whose training materials are available as Open Educational Resources (OER).

The TRIPLE Training Toolkit (result 2) targets training organisers and research performing organisations who wish to design and manage training events as OERs and increase the impact of their training following good practice. The Toolkit is an easily reproducible workflow designed to help trainers minimise the time they spend in managing training events following FAIR practice. The workflow follows a FAIR-by-design method to address the frequent findability and reusability issues related to the management of digital training resources.
How to diagnose, treat and prevent from hospital-acquired and ventilator-associated pneumonia?
Authors: Babiak Rafał , Bajak Karolina , Czuchryta Paulina , Domańska Anastazja , Gawęda Agnieszka , Grabek Agata , Rutkowska Julia , Rzęsa-Tokarczyk Żaneta , Skorek Klaudia , Urbańczyk Agnieszka
Published: June 2023

Introduction and purpose: hospital-acquired pneumonia and ventilator-associated pneumonia are common risk factors for morbidity and mortality. They are difficult to diagnose and treat due to the large number of factors that may contribute to the deterioration of the clinical condition of critically ill patients. In this article, the authors summarize the diagnosis, treatment and prevention of these diseases based on current guidelines, the latest research and other scientific works.

Material and metod: sources available in the PubMed database were analyzed using the following keywords: "pneumonia", "hospital-acquired pneumonia", "ventilator-associated pneumonia", "HAP", "VAP", publications related to the subject of the work were selected and used.

Conclusion: A patient with HAP or VAP should undergo non-invasive testing such as blood and sputum cultures and nasal swabs to isolate the pathogen responsible for the infection and to adjust antibiotic therapy. The procalcitonin level can be used in conjunction with the clinical assessment to assess the adjustment of the duration of treatment. Patients with HAP or VAP who are immunocompromised, haemodynamically unstable, or cannot be sampled from the lower respiratory tract for microbiological testing should be treated with empiric antibiotics based on individual risk factors and antibiotic resistance.
Corporate Purpose in Comparative Perspective: The Role of Governance
Authors: Aguilera Ruth V.
Published: June 2023

Corporate purpose has become a central part of doing business as usual and in the social movement to involve corporations in solving complex societal and environmental challenges. In this essay, I first deconstruct what corporate purpose means from a sociological perspective, and I submit that it is important to identify to whom that purpose is targeted. Second, I seek to make the point that corporate purpose is not universal in that there is not a one-rule-fits-all template on how to develop corporate purpose. I draw on comparative corporate governance, stakeholder management, and institutional theory arguments to illustrate how corporate purpose means different things in different societies and that the departure point of the emanation of corporate purpose varies across countries. This differential meaning is explained in part by the institutional setting as well as very different societal expectations of corporations. Finally, building on insights from existing corporate governance research, I argue that stakeholder engagement can be a useful tool toward effectively deploying corporate purpose.

History: This paper has been accepted for the Strategy Science Special Issue on Corporate Purpose.
Fatores associados à terapia nutricional domiciliar em pacientes sob cuidados paliativos
Authors: Cavagnari Mariana Abe Vicente , Velho Caroline Farias , Mazur Caryna Eurich , Pellissari Maria Theresa Melhem
Published: June 2023

Introdução: A desnutrição é uma das condições frequentemente observadas em pacientes sob cuidados paliativos, afetando a via de alimentação e impactando na diminuição da ingestão alimentar. O atendimento nutricional permite a identificação das alterações nutricionais, direcionando para terapia nutricional adequada. Objetivo: Analisar a terapia nutricional domiciliar e identificar o estado nutricional em pacientes sob cuidados paliativos no domicílio. Método: Estudo prospectivo, observacional com pacientes do Programa Melhor em Casa, em Guarapuava-PR. Foram avaliados por meio de anamnese, que compreendia diagnóstico clínico, exame físico, caracterização e intercorrências da dieta, SARC-F e avaliação antropométrica. Resultados: Participaram do estudo 24 pacientes, com média de idade 70,2+15,0 anos. Os principais diagnóstico clínicos foram: 45,83% câncer e 45,83% doença neurológica. O baixo peso e a classificação sugestiva de sarcopenia predominaram nos avaliados, sendo 54,17% e 87,5%, respectivamente. A via de acesso para alimentação prevalente foi a oral (45,8%), seguida de 41,7% para sonda nasoenteral; a fórmula mais utiliza foi a hiperproteica. A maioria apresentou sinal da asa quebrada (70,8%), perda da bola de Bichat (66,7%) e perda de massa nos membros superiores e inferiores. O diagnóstico nutricional padronizado mais frequente foi NC-3.2 (perda de peso não intencional), seguido de 41,7% com NI-1.2 (ingestão de energia subótima). Conclusão: Observou-se que a maioria dos pacientes eram idosos, acamados, com doença neurológica e câncer. Em relação ao estado nutricional, a maioria apresentou baixo peso e sinais de desnutrição. O atendimento nutricional com pacientes em cuidados paliativos se faz necessário, pois são pacientes com risco nutricional.
Segurança Alimentar e nutricional na Tekoa Pyau, aldeia guarani do município de São Paulo
Authors: Maymone Cristiana Marinho
Published: June 2023

Introdução: Os Guarani da Tekoa Pyau, aldeia localizada no município de São Paulo, estão confinados em uma pequena área ameaçada por disputas territoriais e com intensa urbanização no entorno. Esses fatores dificultam as atividades tradicionais e permitem afluxo crescente de pessoas e mercadorias da cidade, fazendo com que a vida na aldeia não prescinda de produtos industrializados, afetando questões políticas, ambientais, econômicas, espirituais, sociais e de saúde. As compreensões sociocosmológicas que orientam saberes e práticas relacionadas à alimentação no contexto podem ser potentes ferramentas de promoção de alianças entre sistemas próprios de alimentação e a política nacional. Objetivo: Debater Segurança Alimentar e Nutricional com interface das políticas públicas na aldeia e realizar proposições para sua efetividade. Método: A etnografia foi escolhida para compreender um mundo em que as práticas alimentares só podem ser apreendidas em seus significados locais. Resultados: Os Guarani categorizam os alimentos em “mortos” (os que foram comprados nos mercados e enfraquecem os corpos) e “vivos” (os extraídos da natureza que os fortalecem). Entre os “vivos” existe o avaxi etei (‘milho verdadeiro’), dádiva de Nhanderu (‘Nosso Pai’, divindade) e base da alimentação tradicional; entre os “mortos”, estão os ultraprocessados. Conclusão: Ao analisar os dados, pondera-se mau uso de gerência pública com distribuição inadequada de fórmulas infantis, invisibilidade política e alimentação escolar sem afinidade com a alimentação tradicional. Para construir políticas públicas, é importante considerar o vínculo entre a alimentação e a cosmologia e compreender as práticas de saúde dos Guarani.
Perceptions of Brazilian young adults about cooking
Authors: De Camargo Anice Milbratz , Mazzonetto Ana Cláudia , Le Bourlegat Isabelle Schroeder , Dean Moira , Fiates Giovanna Medeiros Rataichesck
Published: June 2023

Introdução: Cozinhar em casa pode promover uma alimentação mais saudável. Porém, uma possível redução na transmissão de conhecimentos e habilidades culinárias parece prejudicar a confiança e a autonomia dos jovens para preparar as refeições. Para informar o desenvolvimento de iniciativas que apoiem os adultos jovens a superar as barreiras para cozinhar e melhorar a qualidade da dieta, é importante investigar o processo de socialização culinária no contexto de seu próprio curso de vida. Objetivo: Este estudo qualitativo teve como objetivo explorar como adultos jovens que têm o hábito de cozinhar percebem seu envolvimento com essa prática e identificar quais agentes socializadores culinários fizeram parte de seu processo de aprendizagem. Método: Entrevistas abertas baseadas na abordagem da perspectiva do curso de vida foram realizadas com adultos jovens brasileiros de 19 a 24 anos de ambos os sexos e analisadas tematicamente. Resultados: As percepções sobre cozinhar e sobre aprender a cozinhar levaram à criação de seis temas: (1) “Cuidar de mim”; (2) “Sentimentos (des)agradáveis”; (3) “Promover o convívio”; (4) “Preocupação com os resultados”; (5) “Habilidades necessárias”; e (6) “Agentes de socialização”. Conclusões: As iniciativas para permitir que os adultos jovens superem as barreiras para cozinhar e potencialmente melhorar a qualidade da dieta precisam se concentrar não apenas no desenvolvimento prático de habilidades culinárias, mas também em habilidades alimentares, como planejamento. Também é importante fomentar mensagens positivas envolvendo autocuidado, prazer e convívio. Formas de usar a internet e as mídias sociais para engajar essa população a cozinhar mais merecem ser mais bem exploradas.
Efeitos da suplementação de óleo de abacate sobre o perfil lipídico e índices aterogênicos em intervenção duplo-cego e randomizada em pacientes com síndrome metabólica
Authors: Souza Fernandes Azevedo Ana Carolina , Cardoso de Lima Mário Flávio , Lawall Lopes Ramos Erika , Boroni Moreira Ana Paula , Teodoro de Souza Claudio
Published: June 2023

Introdução: A síndrome metabólica é definida como um conjunto de condições clínicas que acometem cerca de 25% da população mundial e 29,6% dos brasileiros. Essa síndrome está relacionada ao aumento dos desfechos cardiovasculares, que podem ser preditos através do perfil lipídico. Compostos bioativos, tais como os ácidos graxos monoinsaturados (MUFA), são fortes aliados na prevenção desses desfechos. Um alimento importante por conter compostos bioativos e MUFA em abundância é o abacate. Há, porém, poucos estudos avaliando o efeito do óleo puro/virgem de abacate sobre o perfil lipídico em humanos com síndrome metabólica, e seus efeitos sobre os índices aterogênicos inexistem. Objetivo: O estudo buscou avaliar a suplementação de óleo de abacate sobre os níveis lipídicos e índices aterogênicos em pacientes portadores de síndrome metabólica. Método: 31 indivíduos adultos e obesos foram randomizados em grupo controle (óleo de soja) e grupo intervenção (óleo de abacate). Estes foram avaliados nos períodos pré e pós-intervenção (12 semanas) através de anamnese clínica e avaliação nutricional. Resultados: Observou-se que tanto o grupo controle quanto o grupo intervenção tinham a ingestão de lipídeos e gordura saturada maior que o recomendável. Quanto ao perfil lipídico e índices aterogênicos, não foi observada diferença significativa entre os períodos pré e pós. Conclusão: Os resultados podem ter se dado pela ausência do controle alimentar, sobrecarga de medicamentos, duração da intervenção, modo de administração e dose do suplemento. Logo, são necessários estudos futuros sobre os efeitos do óleo de abacate nessa população, que controlem melhor essas variáveis.
Sosialisasi Halal dan Pendampingan Sertifikasi Halal untuk UMKM Produk Olahan Kurma di Pusat Edukasi Kurma Kediri
Authors: Kurniawan Fredy , Akhlus Syafsir , Juwono Hendro , Suprapto Suprapto , Santoso Eko , Madurani Kartika , Grasianto Grasianto
Published: June 2023

Produk Halal adalah produk yang dinyatakan Halal sesuai syariat Islam. Semua produk yang dijual oleh UMKM Produk Olahan Kurma di kota Kediri belum tersertifikasi halal. Sertifikat halal yang tertera pada produk dapat memberi rasa aman terhadap konsumen dan produk tersebut mampu bersaing di pasaran. Oleh sebab itu, dilakukan kegiatan pengabdian masyarakat berupa sosialisasi dan pendampingan sertifikasi halal untuk produk olahan kurma Kediri. Kegiatan tersebut diawali dengan pengenalan tentang halal dan syarat serta aturan dalam sertifikasi halal. Setelah sosialisasi, kegiatan dilanjutkan dengan pendampingan UMKM yang mendaftarkan produknya untuk sertifikasi halal. Pendampingan ini dilakukan oleh mahasiswa KKN yang telah mengikuti pelatihan kader penggerak halal sebelumnya. Terdapat delapan produk yang diajukan untuk sertifikasi halal. Penyerahan plakat binaan Pusat Kajian Halal juga telah dilakukan untuk delapan produk tersebut.
Program Abmas Sedekah Sampah untuk Kayakan Literasi (DESA KASI) di Desa Wanar, Pucuk, Lamongan
Authors: Suryo Is Bunyamin , Sudarmanta Bambang , Baiturrochman Firlana , Vianita Deviana Dyah , Afifah Putri Almas Ilka
Published: June 2023

Desa Wanar terletak di Kecamatan Pucuk, Kabupaten Lamongan, Jawa Timur. Dengan jumlah penduduk yang terus bertambah, beberapa masalah lingkungan dan masalah sosial bermunculan. Masalah lingkungan terkait pembuangan sampah rumah tangga, sedangkan masalah sosial terkait semakin banyak anak-anak yang kecanduan game online sehingga mengganggu proses belajar. Rencana penyelesaian kedua masalah lingkungan dan sosial ini dirumuskan melalui program DESA KASI (seDEkah SAmpah untuk KAyakan literaSI). Tim abdimas melakukan pendampingan untuk pengolahan sampah rumah tangga sehingga sampah yang bernilai ekonomis akan dipisahkan dan dijual. Untuk mengurangi kecanduan game online, tim abdimas akan membuat perpustakaan keliling bagi anak-anak dan disediakan kupon berhadiah bagi pembaca buku di perpustakaan keliling. Untuk menunjang terlaksananya program ini, tim abdimas akan mendesain dan menyediakan Kendaraan Tiga (3) Roda Multiguna, yaitu kendaraan yang didesain untuk mengangkut sampah RT bernilai ekonomis dan juga bisa berganti fungsi menjadi perpustakaan keliling. Tim abdimas akan bekerjasama dengan mitra kelompok masyarakat Desa Wanar, yaitu Pemuda dan Jama’ah Ibu Masjid Al Mubarok Desa Wanar, TPA Al Mubarok, dan SDN Wanar. Dari Program DESA KASI ini, beberapa manfaat yang diharapkan adalah masyarakat mengetahui tata kelola sampah, mengurangi pencemaran lingkungan, meningkatkan minat baca anak-anak sekolah dasar sehingga mereka memiliki kekayaan literasi, mengurangi kecanduan game online bagi anak-anak, dan sebagai sarana pengabdian masyarakat bagi dosen dan KKN mahasiswa ITS. Selain itu, mitra lokal perlu berkolaborasi dengan Pemerintah Desa setempat untuk keberlangsungan Program DESA KASI.
Pendampingan Sertifikasi Halal Program Self Declare pada UMKM Binaan Koperasi Wanita Setia Bhakti Wanita Surabaya
Authors: Zuchrillah Daril Ridho , Pudjiastuti Lily , Karisma Achmad Dwitama , Pradityana Atria , Tjahyanto Aris
Published: June 2023

Koperasi merupakan salah satu pilar dari perekonomi Indonesia dimana tujuannya adalah mensejahterakan anggota-anggotanya. Fungsi koperasi di Indonesia beragam mulai dari sebagai tempat simpan pinjam hingga wadah pembinaan usaha mikro kecil dan menengah. Koperasi Wanita Setia Bhakti Wanita Surabaya berdiri sejak 1975 merupakan koperasi Wanita yang memiliki binaan UMKM yang cukup banyak. Namun kesadaran yang dimiliki oleh UMKM binaan Kopwan SBW terkait sertifikasi halal cukup rendah. Hal tersebut terbukti di tenan pujasera di lingkungan kantor Kopwan SBW yang masih belum memiliki NIB hingga sertifikat halal. Sehingga tim abdimas dari ITS mendampingi UMKM binaan Kopwan SBW dengan 4 strategi yaitu menjadikan mahasiswa KKN untuk pendamping halal, melatih para UMKM dengan mengikuti pelatihan Kader Penggerak Halal untuk menjadi penyelia halal, pendampingan pengisian SJPH melalui program Self Declare yang merupakan program percepatan dan gratis oleh pemerintah, serta diakhiri dengan pemberian plakat binaan dari Pusat Kajian Halal ITS Surabaya. Hasil diskusi dengan pengurus Kopwan SBW telah diberikan 10 UMKM yang siap produknya bisa didampingi untuk disertifikasi halal. Kegiatan ini memenuhi dalam tujuan pengembangan keberlanjutan sesuai nomor 2 dan 3 yaitu mengakhiri kelaparan, mencapai ketahanan pangan dan nutrisi yang lebih baik dan mendukung pertanian bekerlanjutan dan memastikan kehidupan yang sehat dan mendukung kesejahteraan bagi semua untuk semua usia.
Alat Peraga Edukatif Terkait Mitigasi Gempa Bumi di SDN Candimulyo 1 Madiun
Authors: Saifuddin Saifuddin , Sungkono Sungkono , Indrawati Susilo , Minarto Eko
Published: June 2023

Gempa bumi adalah fenomena yang sering terjadi di Indonesia, namun kejadian gempa secara pasti belum bisa diprediksi hingga saat ini. Terlebih lagi, masih banyak masyarakat Indonesia menghubungkan fenomena kegempaan dengan mitos-mitos yang belum tentu kebenarannya. Oleh karena itu, tim pengabdi dari Departemen Fisika, Institut Teknologi Sepuluh Nopember (ITS) melaksanakan kegiatan sosialisasi alat peraga edukatif tentang gempa bumi untuk siswa kelas 6 di SDN Candimulyo 1 Madiun, Jawa Timur, sehingga fenomena kegempaan lebih mudah dipahami. Kegiatan tersebut juga melibatkan mahasiswa KKN. Kegiatan ini diharapkan dapat menanamkan literasi tentang kegempaan pada usia dini beserta mitigasi gempa bumi untuk pengurangan risiko bencana (disaster risk reduction). Tim pengabdi menyerahkan alat peraga edukatif tersebut dan modul kepada SD tersebut sehingga dapat digunakan sebagai alat pembelajaran berkelanjutan
Dog friendly clinics: helping pets have a positive experience
Authors: Main Kate
Published: June 2023

As one of the project leads for the dog friendly clinic scheme, Kate Main, Veterinary Intervention Development Officer at Dogs Trust outlines key areas of how the initiative can improve veterinary visits for dogs.
Life-threatening and terminal illness: considerations for hospitalised Orthodox Jewish patients
Authors: Tatz Akiva
Published: June 2023

For Orthodox Jewish patients, palliative care in general and withholding and withdrawing treatment in particular pose potential conflicts with some aspects of current religious practice. This article gives an introduction to the relevant cultural context and summarises the relevant principles of Jewish law to help clinicians provide appropriate care for their Jewish patients.
Human factors and ergonomics
Authors: Bailey Craig R , Shorrock Steve , Fong Kevin
Published: June 2023

Human factors and ergonomics in healthcare is an important discipline that considers both the physical and mental characteristics of healthcare workers, as well as the complex interactions within which organisations exist.
An employer's guide to grievance procedures
Authors: Dosanjh Kash , Bernstein Adam
Published: June 2023

In this article, Kash Dosanjh and Adam Bernstein discuss the grievance process and advise employers how to resolve employees' grievances.
The evolution of care settings: from one-room hospital wards to multi-unit care homes
Authors: Ashurst Adrian M
Published: June 2023

Nursing and Residential Care is currently celebrating its 25th volume. Adrian Ashurst reflects on the changes that he has seen in care settings over the past two decades.
“SULARIN DİBİNE DALIŞ” MOTİFLİ DÜNYANIN YARATILIŞ MİTİ IŞIĞINDA KARŞILAŞTIRMALI MİTOLOJİ VE ARKEOLOJİK YAKLAŞIM
Authors: EREN Mariia
Published: June 2023

Etrafında sadece sular varken birinin (dalgıç kuşu, Ak kuş, altıngöz kuşu, kırlangıç, kuğu, kaplumbağa, yengeç, karides, yabani domuz, şeytan vb.) suya dalmasını ve bir avuç toprağı getireni anlatan dünyanın yaratılışıyla ilgili dalgıç miti, en arkaik kozmogoni mitlerinden biri sayılmaktadır. “Kötü Tanrı”nın (şeytan) suya dalması konusuna ilişkin Baltık-Slav bölgesinin 24 noktasında, Fin-Ugor topraklarında ise 12 örnek yer almaktadır. Bunun yanı sıra, 12 bin yıl önce meydana geldiği varsayılan bu mit, Güney Asya ve Kuzey Amerika’da da bulunmuştur. Mitoloji ve folklor kaynaklarının arkeoloji, antropoloji, hatta genetik bilimiyle birlikte de bir bütün olarak araştırıldığı takdirde eski insanların göç ettiği yolların da takip edilmesi mümkün kılınmaktadır. Çalışmamızda Türkiye’de ilk defa bahsedilecek ve Rus bilim insanı Ye. Yu. Beryozkin tarafından geliştirilmiş “Bölgelere Göre Folklorik-Mitolojik Motiflerin Yayılması ve Tematik Sınıflandırılması” (Rus. “Тематическая классификация и распределение фольклорно-мифологических мотивов по ареалам”) adlı kapsamlı proje ele alınacaktır. Söz konusu katalog sayesinde folklor ve mitolojik motiflerinin dünyadaki bölgelere göre dağılmasını görsel olarak tespit etme imkânı mevcuttur. Mitolojide ve halk biliminde kullanılabilecek bu yönteme “arkeolojik yöntem” denilebilir. Ye. Yu. Beryozkin, mitolojik ve folklorik unsurları içeren ürünlerin araştırılmasını “folklor arkeolojisi” olarak adlandırmaktadır. Çalışmada yabancı bilimsel kaynaklar ile birlikte Beryozkin’in kataloğuna da dayanarak “dalgıç” motifli mitlerle ilgili bir değerlendirme yapılmakta ve harita üzerinde örnekler gösterilmektedir. “Dalgıç” konusunu içeren dünyanın yaratılışına ilişkin mitler, çeşitli halklara ve kültürlere rastlandığından karşılaştırmalı-tarihî yöntemin önemi de vurgulanmaktadır.
TÜRK KÜLTÜRÜNDE AĞAÇ VE FATİH ALBÜMÜNDEKİ KÂĞIT OYMA AĞAÇLAR
Authors: ERYILMAZ Burcu
Published: June 2023

Kültür; toplumların yarattığı maddi ve manevi değerler bütünüdür. Yaşanılan iklim, coğrafya, sosyal çevre, inanç yapısı gibi değişkenlere göre biçim almış ve uluslara özgü geleneksel kültür değerlerini oluşturmuştur. Kültür içerisinde yoğrulan manevi kültür ürünleri semboller dünyasının alanı içindedir. Orta Asya’dan Anadolu’ya uzanan geniş bir coğrafyada kültür ürünlerinde bulunan semboller, toplumlar arasındaki kültürel etkileşimi, din ve görenek gibi toplumsal var oluşun sürecindeki dinamikleri etkilemiştir. Yüzyıllar boyunca birçok kültür, yaşam karşısında birçok duygu ve düşüncelerini çeşitli bitkilere anlamlar yükleyerek sembolleştirmişlerdir. Ağaç da Türkler için önemli bir semboldür. Orta Asya Türklerinde bitki ve ağaç sembolizmi ilk yaradılış efsaneleri ile başlar. Orta Asya Türk Mitoloji ve inanışlarında kayın, çam, sedir, elma, ardıç vb. ağaçlar genel olarak kutsal sayılmış, hatta insanın ağaçtan türediğine dek uzanan bir ağaç kültü gelişmiştir. Kültürümüzün önemli bir bölümünü oluşturan geleneksel Türk süsleme sanatları içinde yer alan bütün alanlarda çeşitli ağaç motiflerini görmek mümkündür. Günümüzde kaybolmaya yüz tutmuş geleneksel kitap sanatlarımızdan biri olan Katı’ sanatı; 15. yy’da Fatih albümü ile Türk kültüründe ağaç kültünün önemini bizlere göstermektedir. Bu albümde, bu inanç doğrultusunda ince işçilikli ve detaylı bir uygulama ile üstün eserler ortaya konmuştur. Bu albümde bulunan oyma ağaç eserler incelenerek katı’ sanatının önemi, ağaç kültünün Türk kültürüne olan etkisinin ve sanata yansımasının ortaya konması amaçlanmaktadır.
BİR VİCDAN MUHASEBESİ: SODOM VE GOMORE
Authors: GÖNCÜ Müge
Published: June 2023

ÖZ: Milli Mücadele dönemi romanları anlatılan olaylara farklı açılardan bakabilmek için okura fırsat verirler. Yakup Kadri Karaosmanoğlu, Sodom ve Gomore romanında işgal altındaki İstanbul’un ahvalini sapkın yaşam tarzları nedeniyle helak edildiklerine inanılan Sodom ve Gomore şehirleriyle bir tutar. Romanın ana kahramanı Necdet yaşamak zorunda bırakıldığını hissettiği hayat tarzıyla içindeki milli mücadele ruhu çarpışınca derin bir suçluluk duygusuna kapılır. Bu çalışmanın temel amacı suçluluk duygusu ve vicdan kavramı üzerinden Yakup Kadri Karaosmanoğlu’nun Sodom ve Gomore romanında suçluluk hissinin nedenlerini, görünme biçimlerini ve sonuçlarını ortaya koyarak anlam çözümlemesi yapmaktır. Yakup Kadri’nin hem milli mücadele İstanbul’unun yozlaşmış yönünü ortaya koymak hem de aynı şehirde suçluluk duygusuyla kıvranan bireyleri göstermek adına Sodom ve Gomore benzetmesini kullandığı görülmektedir.
ÇORUM LEBLEBİSİ VE HEDİYELİK KUTUDAKİ GEZGİN KENT BELLEĞİ İMGELERİ
Authors: ŞAHİNER Ahmet Emin
Published: June 2023

Öz: Bu çalışmada; bir kentin doğal, tarihi, kültürel mirasında yer alan bir ögenin kültürel imgeye, bu imgenin de kültürel ekonomik alanda ve kültür turizminde kenti simgeleyen bir markaya dönüşmesi ele alınmıştır. Çalışmanın amacı, Çorum leblebisi örneklemi üzerinden kültürel küreselleşme karşısındaki yerelin öne çıkma süreçlerinde kent imgelerinin rolü ve önemini tartışmaktır. Konuyla ilgili yazılı ve elektronik kültür ortamından doküman analizi tekniğiyle veri toplanmış ve bu veriler incelenmiştir. Çorum leblebisinin yerel işletmeciler tarafından açılan sanal/dijital alandaki genel ağ sayfaları incelenmiş, e-ticarete dönüşen leblebicilik mesleğini üzerinde durulmuştur. 21.yüzyılda bir kent için bir ürünün “anavatanı” sayılmak yerine, o ürünü kültürel bir imge olarak kültürel ekonomik alanda kullanıp çok yönlü kazanç elde edebilmek ve kültür turizmi alanından pay alabilmek daha önemlidir. Çorum leblebisinin, kültürel imge olarak ekonomik alandaki varlığı ile kültür turizmine katkıları değerlendirilmiş; Türk hediyeleşme geleneği bağlamında Çorum leblebisinin yerel işletmelerde ve genel ağ sayfalarındaki satışlarda kullanılan hediyelik leblebi kutularının yaratıcı tasarımlarına kentin belleğinin yansıtıldığı görülmüştür. Kentin doğal, tarihi ve kültürel mirasının hediyelik leblebi kutularına yansıtılması; kültürün korunmasına, yaşatılmasına, sürdürülebilir olmasına; kültürel ekonomik alanda kente katkı sağlayarak kültür turizminin artmasına vesile olmaktadır.
Numerical Simulation of Effect of Inclination Angle on Heat Storage Properties of Phase Change Paraffin
Authors: Hou Feng , Qu Jingying , Bian Zhen , Wang Hui , Bai Yang
Published: June 2023

In order to explore the heat storage properties of phase change paraffin, a calculation model for melting heat storage of phase change paraffin was established based on the equivalent heat capacity method. A finite element software (COMSOL) was used to study the influence of different inclination angles on heat storage properties of phase change paraffin. The results show that the melting process of phase change paraffin is determined by heat conduction and natural convection heat transfer, natural convection heat transfer plays a significant role in the process of heat storage in phase change paraffin. Phase change paraffin exhibits distinct melting heat storage efficiency under different inclination angles. When changes from -90° to 90°, the melting time of paraffin decreases gradually. When , the melting time of paraffin is the slowest, when , the melting time of paraffin is the fastest, and the melting speed of paraffin is increased by about 8.6 times.
Optimization of Efficient Perovskite-Si Hybrid Tandem Solar Cells
Authors: Shukla Naman , Verma Anil Kumar , Tiwari Sanjay
Published: June 2023

Perovskite-silicon tandem solar cells have attracted much attention to photovoltaic community because of their high efficiency via easy fabrication methods and availability of precursor material abundant in nature. The properties of both perovskite and silicon meet ideal solar cell standards such as high light absorption potential, long carrier diffusion length and fast charge separation process. Semi-transparent solar cell with widely tunable band gap of perovskite material is compatible with silicon solar cell for tandem structures. A perovskite-silicon tandem solar cell four terminal configuration optimization was performed through numerical simulation. The optimized four terminal perovskite-silicon tandem solar cell performances was investigated by varying the thickness of top and bottom solar cell absorber layers, defect density of the absorber layer, and temperature. Perovskite-silicon tandem solar cell showed better photovoltaic performance under constant illumination condition. A high performance mechanically attached four terminal (4-T) perovskite-silicon tandem solar cell has total power conversion efficiency (PCE) of 34.88% by optimized parameters through simulation. It has shown 37% efficiency with matched current of 23.71mA/cm2. These numerical simulation results are provided the parameter values for further experimental assignment.
Preparation and Characterization of Nanohybrids Made of Graphene Oxide as Super Adsorbents
Authors: Grover Komal , Jeet Kiran
Published: June 2023

Adsorption is considered one of the best methods for the removal of heavy metal ions from an aqueous solution. However, the synthesis of adsorbents with desired selectivity and performance remains a key challenge in the battle of water decontamination. Recently, carbon-based and metal-oxide based nanomaterials have emerged as promising candidates for the adsorption of heavy metals due to their high specific surface area, high aspect ratio, and concentrated pore size distribution. Here, in this work five adsorbents ie. Graphene Oxide (GO), Magnetic Graphene Oxide (MGO), Titanium Dioxide (TiO2), and their composites GO-TiO2 and MGO-TiO2 were synthesized. The prepared samples were characterized via high-resolution imaging, BET-N2 adsorption-desorption analysis, and spectroscopic techniques. TEM results revealed the nanoscale structures of the synthesized nanomaterials. The approximate sizes of MGO and TiO2 nanoparticles found under TEM studies were about 24.58 and 35.51 nm respectively. The presence of desired functional groups was very well deciphered by FT-IR spectroscopy. Results of N2 adsorption-desorption studies revealed that the prepared GO was macro-porous while all other samples were mesoporous. MGO was found to have the highest BET surface area of about 108.375 m2/g. These results indicate that the prepared nanomaterials may serve the purpose of effectively adsorbing the heavy metal ions from an aqueous solution.
Ethnomedicinal knowledge of the rural communities of Gulmarg, Jammu and Kashmir, India
Authors: JI ARFA , HAMID ASFER , ANDRABI SYED AASIF HUSSAIN
Published: June 2023

Abstract. Ji A, Hamid A, Andrabi SAH. 2023. Ethnomedicinal knowledge of the rural communities of Gulmarg, Jammu and Kashmir, India. Asian J Ethnobiol 6: 58-64. In the current study, 60 medicinal plants have been collected from Gulmarg, Jammu and Kashmir (India), belonging to 34 families. The plant parts used were dominated by roots (36%), and the collection of roots has depleted the population of certain plant and may endanger the survival of the rare and slowly reproducing medicinal plants. It was found that the old people possessed a good wealth of traditional information as compared to younger generation Therefore, it is imperative to document the medicinal plants and associated information and to require necessary measures for the conservation of those resources. Herbs dominated all other life forms (49 species). The most typical way to consume the medications was by decoction, 32% (22 species). According to the current study the most prevalent disease addressed by the medicinal plants included was gastrointestinal disorders (25 species). Artemisia absinthium L. had the highest Use Value (UV), i.e., 0.58, while Viscum album L. had the lowest UV (0.17). Locals continue to value herbal treatments as a trustworthy means of curing a variety of ailments.
Genetic diversity among five native Thai chickens and Khiew-Phalee chickens in lower-northern Thailand using mitochondrial DNA barcodes
Authors: SIRIWADEE PHROMNOI , WIROT LIKITTRAKULWONG , THANAPOL PUANGMALEE , WIRAWAN NUCHCHANART
Published: June 2023

Abstract. Siriwadee P, Wirot L, Thanapol P, Wirawan N. 2023. Genetic diversity among five native Thai chickens and Khiew-Phalee chickens in lower-northern Thailand using mitochondrial DNA barcodes. Biodiversitas 24: 1962-1970. Native chickens are an important biological resource in Thailand, with each breed having distinctive features. Khiew-Phalee chickens are a valuable investment in cultural wisdom and an invaluable Thai resource worthy of conservation. It is the royal rooster of Phraya Phichai Dab Hak. Due to a crisis concerning a sharp decline in the size of the Khiew-Phalee native chicken population, the identification of potential biomarkers is important for the determination of different chicken breeds for future planning. This study aimed to investigate the molecular identification of different native Thai chicken breeds based on mitochondrial DNA (mtDNA) barcodes, especially Khiew-Phalee chickens, which is difficult using the morphological examination. Partial sequences of 648 bp mtDNA control region fragments were determined for 53 specimens of six breeds of native Thai chickens (Khiew-Phalee, Thao Thong, Leung Hang Khao, Chee, Pra Dhu Hang Dam and Kai Jae). Genetic diversity was accessed based on the number of polymorphic sites, number of haplotypes, haplotype diversity, nucleotide diversity, and average number of differences. A phylogenetic tree was constructed based on maximum likelihood. The results showed that eighteen haplotypes were identified from 9 polymorphic sites with polymorphism between nucleotides 1074, 1107, 1109, 1177, 1213, 1214, 1268, 1276 and 1305. The haplotype diversity, nucleotide diversity, and the average number of differences for all chickens were 0.917, 0.00504 and 2.69086, respectively. All Khiew-Phalee chickens showed 7 haplotypes with 0.897 haplotype diversity, 0.00696 nucleotide diversity, and an average number of differences at 3.1795 clustered with other breeds in the phylogenetic tree. The findings indicated that the DNA barcoding gene is an effective method to identify the Khiew-Phalee and five other native Thai chicken breeds. It is a better choice for using molecular biology DNA barcoding to identify Thai native chicken breeds to plan for further conservation and development by the Department of Livestock Development of Thailand.
Isolation and identification of lactic acid bacteria from traditional food sarobuong of Kuantan Singingi District, Riau, Indonesia
Authors: SARYONO SARYONO , ISMAWATI ISMAWATI , PRATIWI NOVA WAHYU , DEVI SILVERA , SIPAYUNG MERRY YOHANA , SURAYA NABELLA
Published: June 2023

Abstract. Saryono, Ismawati, Pratiwi NW, Devi S, Sipayung MY, Suraya N. 2023. Isolation and identification of lactic acid bacteria from traditional food sarobuong of Kuantan Singingi District, Riau, Indonesia. Biodiversitas 24: 2201-2206. Lactic acid bacteria (LAB) are commonly used as probiotic agents in fermented processed foods like sarobuong. Sarobuong is a traditional food from Kuantan Singingi District made by fermenting bamboo shoots. In this study, the isolation and purification of LAB from sarobuang were done using MRS agar media with the streak quadrant method: macroscopic and microscopic observations and biochemical and physiological tests to identify isolates. The antibacterial ability of LAB isolates was used against pathogenic bacteria Escherichia coli and Staphylococcus aureus. The results showed that 21 isolates were gram-positive bacteria in the form of bacilli and coccus, while carbohydrate degradation was homofermentative. The results of the antibacterial test of 21 isolates indicated by LAB against E. coli and S. aureus bacteria showed a clear zone ranging from 0.1 to 0.6. The highest antibacterial activity against pathogenic bacteria E. coli was observed in isolate RB1, while for pathogenic bacteria S. aureus, it was in isolate R15. The results obtained from several isolates that have been tested showed that LAB isolated from sarobuong had relatively higher activity than the control and was identified as Lactobacillus and Streptococcus.
Effect of Beauveria bassiana and Metarhizium anisopliae on the growth of Spodoptera frugiperda by seed inoculation
Authors: SARI JELLY MILINIA PUSPITA , HERLINDA SITI , SUWANDI SUWANDI , ELFITA ELFITA
Published: June 2023

Abstract. Sari JMP, Herlinda S, Suwandi S, Elfita. 2023. Effect of Beauveria bassiana and Metarhizium anisopliae on the growth of Spodoptera frugiperda by seed inoculation. Biodiversitas 24: 2350-2357. Spodoptera frugiperda J.E.Smith 1797 larvae are more difficult to control because they hide in the leaf sheaths. Therefore, it is necessary to use endophytic entomopathogenic fungi to control S. frugiperda larva. The aim of this research was to observe the effect of endophytic Beauveria bassiana (Bals.-Criv.) Vuill. and Metarhizium anisopliae (Metschn.) Sorok?n on the growth of S. frugiperda larvae by seed inoculation. A total of six isolates of B. bassiana (5 isolates) and M. anisopliae (1 isolate) were isolated from infected-host insect corpses and identified molecularly. The corn seeds were immersed using a fungal suspension of 1 x 1010 conidia mL-1. The results showed that feeding on maize leaves colonized with B. bassiana (JGTP240521A, WTTJC260521A, WTTJC290521A, WTTJC290521B, and JGNT300521 isolates) and M. anisopliae (WTTJC260521B isolate) significantly reduced the larval and pupal weight. The highest mortality (above 50%) of S. frugiperda larvae was recorded by B. bassiana (JGTP240521A isolate) . The treated larvae could produce abnormal and malformation pupae and adults, increasing mortality. Both fungi killed the larvae and induced disruption of normal growth larvae, pupae, and adults of S. frugiperda. B. bassiana was more pathogenic than M. anisopliae in killing the larvae of S. frugiperda. Results revealed that endophytic fungi B. bassiana and M. anisopliae inoculated through seed treatment had a negative impact on the growth of S. frugiperda larvae. Further studies are needed on the effect of B. bassiana and M. anisopliae by foliar spraying or seed treatment on maize plant to control S. frugiperda in the field.
Application of organic fertilizer enriched with Trichoderma harzianum on shallot (Allium cepa) cultivation in ultisols
Authors: GOFAR NUNI , NUR TRI P. , PERMATASARI SHINTA D. I. , MUSLIMAH SITI , FIKRI HAMDHANIE , HARYONO ANUNG , PUJIATI PUJIATI , UTAMI HANA ALFIANITA
Published: June 2023

Abstract. Gofar N, Nur TP, Permatasari SDI, Muslimah S, Fikri H, Haryono A, Pujiati, Utami HA. 2023. Application of organic fertilizer enriched with Trichoderma harzianum on shallot (Allium cepa) cultivation in ultisols. Biodiversitas 24: 2426-2433. Shallot is a critical commodity with substantial economic value. However, several factors, such as pests and diseases, negatively impact its low productivity. Therefore, to address these challenges, the agricultural sector is developing an organic fertilizer enriched with the biological agent Trichoderma harzianum. This biological agent improves soil fertility, controls Fusarium wilt, and enhances shallot production. This study aimed to evaluate the effectiveness of organic fertilizer enriched with Trichoderma harzianum in suppressing the growth of Fusarium oxysporum and increasing shallot production. Therefore, it included five treatments of organic fertilizer enriched with Trichoderma harzianum at varying concentrations of 0, 200, 300, 400, and 500 kg ha-1. The results showed that applying 400 kg ha-1 organic fertilizer enriched with Trichoderma harzianum suppressed the Fusarium wilt. The dose of 500 kg ha-1 had the highest pH value of 5.50-5.78 among other treatments and increased 55.7% shallot production on Ultisols compared to the application of NPK 16-16-16. Based on these results, organic fertilizer enriched with Trichoderma harzianum could improve soil fertility, increase production and control the Fusarium wilt on shallot.