bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH PERKEMBANGAN TEKNOLOGI, MEDIA SOSIAL, HARGA, DAN LOKASI TERHADAP PENDAPATAN UMKM DI KOTA LANGSA: MENGEKSPLORASI DINAMIKA SUKSES BISNIS DI ERA DIGITAL
Authors: Ulfa Maria , Kurlillah Anis , Pospos Ade Fadillah FW , Budiman Iskandar
Published: December 2024

This study aims to determine the influence of each variable, namely technological development, social media, price, and location on the income of micro, small, and medium enterprises (MSMEs) in the city of Langsa. The method used is quantitative with multiple regression analysis. The population in this study is micro, small, and medium enterprises (MSMEs) in Langsa City totaling 24,684 units. The sampling technique in this study uses Proportionate Stratified Random Sampling technique with a total of 100 respondents. Based on the test results, the Social Media and Location variables have a significant effect on MSME Income in Langsa City, while Technological Development and Price variables do not have a significant effect on MSME Income in Langsa City. Meanwhile, for the simultaneous test results presented, it can be seen that the Ftest value is 25.810 > the value of Ftable (2.70) and significant at 0.000 < 0.05. Therefore, it can be concluded that the four independent variables, namely Technological Development, Social Media, Price, and Location, simultaneously have a positive and significant effect on MSME Income with an adjusted coefficient of determination (adjusted R2) obtained at 0.446. This indicates that the variables of Technology, Social Media, Price, and Location are able to explain 44.6% of the variation in MSME Income, while the remaining 55.4% is influenced by other variables not examined in this study.
PAKANI: SUSTAINABLE OF BLUE ECONOMY MELALUI ISLAMIC DIGITAL PLATFORM DALAM UPAYA MEMBERDAYAKAN PETANI IKAN DI JAWA TIMUR
Authors: Dwi Seftiana Ananda Sarno Fajar
Published: December 2024

This study examines digital innovation through the PAKANI platform as a solution to support the implementation of a sustainable blue economy concept and empower fish farmers in East Java. PAKANI is designed as a technology-based application that provides comprehensive access to sharia financing, affordable and quality fish feed distribution, and broader marketing access for small-scale fish farmers. Challenges faced by fish farmers in East Java include limited resource access, high production costs, and inefficient distribution. This study employs a qualitative approach with descriptive analysis based on literature from journals, books, scientific reports, and articles to analyze East Java’s geographical potential for inland aquaculture in underutilized lands. The findings show that PAKANI can act as a catalyst in enhancing productivity and sustainability in small-scale aquaculture, particularly through integrating digital technology and sharia-compliant financing that is accessible for fish farmers. The blue economy concept applied in this platform leverages technology to reduce resource waste and support sustainable aquaculture practices aligned with circular economy principles. These findings are expected to make a significant contribution to the academic literature on digitalization in the aquaculture sector and the inclusive development of sharia-based economies, particularly in Indonesia. This platform is anticipated to improve fish farmers’ welfare and increase the fisheries sector’s contribution to sustainable economic growth in Indonesia.
REVITALISASI STRATEGI INOVASI EKONOMI BISNIS DI ERA DIGITAL BERKELANJUTAN UNTUK GEN Z
Authors: Ulya Millatul
Published: December 2024

In the ever-evolving digital era, generation Z has emerged as consumers and workforce with unique characteristics. This study discusses the importance of revitalizing sustainable business economic innovation strategies to meet the needs and preferences of generation Z. This study identifies the challenges and opportunities faced by businesses in adopting digital technology and sustainable practices. Through an analytical approach, this paper explores various innovative strategies that companies can implement to attract and retain generation Z as customers and employees. The results of the study indicate that the integration of technology, sustainability, and social engagement are key factors in creating added value for businesses in the digital era. Thus, companies that are able to adapt and innovate according to the demands of generation Z will have a significant competitive advantage.
Development of the scientific project “mendeleev classes” at the research base of the department of industrial ecology and life safety of the Irkutsk national research technical university
Authors:   Irkutsk National Research Technical University, Maksimova Marina , Tyukalova Olga ,   Irkutsk National Research Technical University, Molokova Elena ,   Irkutsk National Research Technical University, Rogacheva Darja ,   Irkutsk National Research Technical University
Published: December 2024

The article examines the results of implementing a new direction in education: the scientific project “Mendeleev Classes.” It outlines the project’s primary goal and objectives, along with participating regions, stakeholders, and executors. The project program has been implemented at Irkutsk National Research Technical University since 2021, utilizing the research facilities of the Department of Industrial Ecology and Life Safety. Students and staff from the department guide the project activities of the “Mendeleev” 8th-grade students from Lyceum No. 1 in Usolye-Sibirskoye. The article provides a detailed overview of the topics, objectives, and key findings of these projects. The article highlights how active engagement of lyceum students allows them to gain experience in scientific research, while university students broaden and acquire new theoretical knowledge, alongside practical skills in environmental safety. The article provides a description and brief report of four expeditions conducted across Russia in 2021 (“Baikal”), 2022 (“Finnish Gulf”), 2023 (“Southern Ural”), and 2024 (“Kamchatka”). The article notes the pressing ecological problems in Russia’s regions that students from various institutions, including Irkutsk National Research Technical University, encountered. It lists publications showcasing the research findings of participants and their supervisors. The article concludes that the implementation of the “Mendeleev Classes” project contributes to the improvement of the ecological education and upbringing system in Russia, fostering environmental culture and ecological literacy among young people.
Optimizing the volume of drinking water sampling during the radiation and hygienic monitoring around the Belarusian NPP
Authors:   Research Institute of Hygiene, Toxicology, Epidemiology, Virology and Microbiology of the state institution “Republican Center of Hygiene, Epidemiology and Public Health”, Zhukova Olga , Nikalayenka Alena ,   Research Institute of Hygiene, Toxicology, Epidemiology, Virology and Microbiology of the state institution “Republican Center of Hygiene, Epidemiology and Public Health”, Popova Ekaterina ,   Research Institute of Hygiene, Toxicology, Epidemiology, Virology and Microbiology of the state institution “Republican Center of Hygiene, Epidemiology and Public Health”, Huseinava Dziyana ,   Research Institute of Hygiene, Toxicology, Epidemiology, Virology and Microbiology of the state institution “Republican Center of Hygiene, Epidemiology and Public Health”
Published: December 2024

Drinking water sampling is one of the key stages of radiation hygiene monitoring (RHM), both for planned radiation in the Belarusian NPP observation zone and for existing radiation in the areas affected by the Chernobyl accident. In Belarus, there is no uniform methodological document establishing the quantities of drinking water samples required to determine radiological indicators. The purpose of the paper wasto analyze the results of the radionuclide content study carried out in the Belarusian NPP observation zone and to justify the quantity of samples needed. In the 2017-2022 RHM, water samples from centralized (artesian wells) and non-centralized (wells) drinking water sources were taken in reference settlements located in the NPP's Belarusian observation zone. On the basis of the results of the research, the quantities of drinking water samples required and sufficient from wells have been evaluated. The study found that if the water is characterized by low levels of 137Cs activity (less than 0.01 Bq/l), the sample volume should be at least 100-150 l, and for 90Sr - at least 80 l. The data will allow selecting the required volumes of drinking water samples to determine the volumetric activity of radionuclides, including man-made ones - 137Cs and 90Sr, which will allow assessing the radiation safety of water supply sources and ensuring the reliability of the results of studies conducted within the RGM both in case of the planned irradiation (around the Belarusian NPP), and in areas with different levels of radioactive contamination as a result of the Chernobyl accident.
Long-term results of surgical treatment of hepatocellular cancer in Russian real practice
Authors: Petkau V. V. , Rasulov R. I. , Muratov A. A. , Nurbekyan G. V. , Uvarov I. B. , Kirshin A. A. , Orlova R. V. , Popova N. V. , Dinikin M. S. , Khlobystin R. Yu. , Sultanbaev A. V. , Menshikov K. V. , Orlov O. G.
Published: December 2024

Introduction. Hepatocellular cancer (HCC) ranks 3rd in the structure of cancer mortality, remaining a social and economic problem. Surgical treatment is the main radical treatment for HCC in the early stages. Russian data on approaches to selecting patients for surgery and on long-term results of treatment of patients with HCC are not sufficiently presented.

Aim. To evaluate the long-term results of surgical treatment of patients with HCC in routine clinical practice in the Russian population.

Materials and methods. A multicenter (7 centers) retrospective observational study included 178 patients with a confirmed diagnosis of HCC who underwent surgical treatment. Before treatment, the general condition was assessed according to the ECOG scale, the functional state of the liver according to the Child – Pugh scale, and the prevalence of the tumor process according to the Barcelona classification (BCLC). The end points of the study were overall survival (OS), relapse-free survival (RFS).

Results. Resection of various volumes of the liver was performed in 178 patients with HCC: 139 has BCLC 0/A, 29 – BCLC B, 10 – BCLC C. The median RFS was 20.6 months (95% CI 16.7–31.5), median OS – 55.7 months (95% CI 42.4–76.4). RFS significantly depended on the stage of the disease (median RFS at stage BCLC 0/A – 25.6, at B – 10.1, at C – 3.3 months), on the presence of macro- and microvascular invasion (median RFS 7.6 and 13.7 months), from viral or non-viral etiology of HCC (median RFS 18.0 and 22.6 months). OS was negatively affected by disease stage BCLC B and C according to the Barcelona classification (median OS 34.2 versus 5.2 months), viral etiology (median OS 42.4 versus 69.9 months), and occurrence of relapse (median OS 43.3 months).

Conclusion. Data from the largest multicenter study on surgical treatment of HCC in Russian clinical practice were obtained. Liver resections of various volumes are also performed outside the scope of clinical recommendations. 3 out of 4 patients have risk factors for relapse. The data obtained are consistent with international experience in the treatment of patients with HCC.
Experience with perioperative drug therapy in patients with stage III non-small cell lung cancer (results of the observational study CARL-001)
Authors: Laktionov K. K. , Breder V. V. , Allahverdiev A. K. , Kazakov A. M. , Gorokhov A. E. , Yudin D. I. , Stroyakovskiy D. L. , Akhmadiyarova Ya. S. , Kozlov V. V. , Fedun A. M. , Ibragimov T. F. , Sannikova T. A. , Plokhotenko I. V.
Published: December 2024

Introduction. The article considers approaches to the treatment of patients with stage III non-small-cell lung cancer (NSCLC). Particular attention is paid to neoadjuvant and adjuvant drug therapy.

Aim. To evaluate the efficacy of neoadjuvant treatments, such as neoadjuvant chemotherapy and immunochemotherapy, and adjuvant approaches to the stage III NSCLC treatment.

Materials and methods. The results were obtained during the study: Clinical Testing of Lung Cancer (“CARL-001”). A total of 186 untreated patients with stage IIIA-IIIC NSCLC (160 patients with stage IIIA, 25 patients with IIIB and 1 with IIIC) were enrolled in the study. The study included 108 patients with adenocarcinoma and 78 with squamous cell carcinoma. 118 patients underwent surgery with adjuvant polychemotherapy (aPCT), 49 patients underwent neoadjuvant polychemotherapy (neoPCT) followed by surgery, and 19 patients had neoadjuvant immunotherapy combined with chemotherapy (neoICT). The median follow-up was 40 months.

Results. Both adjuvant and neoadjuvant chemotherapy shared equivalent efficacy. The median relapse-free survival (RFS) in the aPCT and neoPCT groups was 30.4 and 32.6 months, respectively (differences between groups were not statistically significant). There was no significant difference in overall survival (OS) either. The use of neoICT showed better results as compared to neoPCT. The median RFS was not reached in the neoICT group, the median RFS in the neoPCT group was 32.6 months. OS was numerically higher in the neoICT group as compared to the neoPCT group, and accounted for 78.9% and 59.18% over a 36-month follow-up period, respectively.

Conclusions. Preoperative chemotherapy is proven to be equal to the postoperative chemotherapy in the treatment of patients with stage III NSCLC. The use of neoICT demonstrated better results as compared to neoPCT. Further study of these treatments will allow a more personalized approach to the treatment of patients with stage III NSCLC.
A clinical case of the effectiveness of the anti PD-1 inhibitor (prolgolimab) in the treatment of metastatic melanoma
Authors: Golubev P. V. , Deshkina T. I. , Bolotina L. V. , Kuzmina E. S. , Golubeva S. A. , Pokataev I. A. , Galkin V. N.
Published: December 2024

Melanoma of the skin is one of the most aggressive cancers. Until recently, metastatic melanoma was associated with an extremely negative prognosis: the median overall survival for this category of patients was no more than 7–8 months. Thanks to the improvement of therapeutic approaches, it was possible to achieve a significant increase in the life expectancy of patients with an unresectable and metastatic process. Currently, several targeted and immunotherapy options are available for the treatment of metastatic or unresectable skin melanoma. These therapeutic approaches have thoroughly taken a leading place in everyday clinical practice and have made it possible to change the natural history of this disease: today about 30–60% of patients can survive 5 years or more. There are 3 immune response checkpoint inhibitors related to PD-1 receptor blockers registered in our country: pembrolizumab, nivolumab and the Russian-made prolgolimab. In this article, we describe a clinical case of effective treatment of a patient with generalized melanoma of the skin using the domestic drug prolgolimab. The article also provides a brief description of the main studies on domestic immunotherapy molecules and their indirect comparison with foreign analogues.
Outstanding issues in perioperative chemotherapy for gastric cancer
Authors: Deshkina T. I. , Bolotina L. V. , Golubev P. V. , Kornietskaya A. L. , Ruban M. S. , Fedenko A. A.
Published: December 2024

Gastric cancer is an important medical and social problem all over the world. The aggressiveness of the course of this disease is reflected by the high figures of one-year mortality, which is due to both high neglect at the time of diagnosis and unsatisfactory results of surgical treatment of even a localized tumor process, which from a biological point of view casts doubt on the possibility of performing a “radical” operation for this type of malignant tumor. Currently, the “gold standard” has become the conduct of perioperative chemotherapy according to the FLOT scheme for locally advanced stages of gastric cancer, esophagogastric junction and esophagogastric junction and lower esophagus. A further promising direction for improving perioperative chemotherapy is the investigation of immune checkpoint inhibitors (pembrolizumab, atezolizumab and durvalumab) in combination with cytostatics. Today, there are still a number of unresolved issues, including the need to continue such aggressive treatment in the postoperative period with an unsatisfactory pathomorphological response from the tumor. Performing the entire volume of chemotherapy is a difficult task, due to the toxicity of this type of treatment and the weakened condition of the patient after extensive surgery. The significance of the pathomorphological regression of the tumor after neoadjuvant chemotherapy is also unclear. Only 10–15% of patients achieve a complete pathomorphological response. The standard postoperative practice is to carry out the same preoperative chemotherapy regimen, regardless of sensitivity to it. The search for prognostic markers will help to individualize the treatment strategy of such patients and protect patients from excessive toxicity with unjustified continuation of chemotherapy.
Palbociclib in real clinical practice: Results of a single-center observational study
Authors: Sultanbaev A. V. , Kolyadina I. V. , Nasretdinov A. F. , Menshikov K. V. , Askarov V. E. , Musin Sh. I. , Akhmetgareeva K. T. , Sultanbaeva N. I. , Zabelin V. M. , Ayupov R. T. , Izmailov A. A.
Published: December 2024

Introduction. A breakthrough in the treatment of metastatic hormone-dependent (HR+) breast cancer was combination endocrine therapy with CDK4/6 inhibitors, which significantly prolonged the tumor response time to treatment and the median survival before progression. The effectiveness of combination endocrine therapy in real-life practice is of particular interest due to the wider population of patients with different somatic status and comorbidity, often not included in randomized trials.

Aim. Analyze of palbociclib using for treating patients with HR+/HER2– advanced breast cancer (mBC) at the Republican Clinical Oncology Dispensary.

Materials and methods. Data from 323 patients were analyzed. Our study examined the effectiveness of combination endocrine therapy with palbociclib in patients with metastatic HR+ HER2– breast cancer. Data on the clinicopathological characteristics of patients and disease progression during palbociclib administration were obtained by reviewing clinical data from patient records and radiological/pathological examination reports.

Results. The median age of patients included in the study was 62 years. When assessing the antitumor response, a partial response was recorded in 54 patients (16.7%), stabilization in 212 patients (65.6%), and progression in 57 patients (17.8%). The median progression-free survival was 13 months. Grade 3 adverse events were noted in 23 patients: neutropenia in 21.7% of cases, hepatotoxicity in 47.8% of cases, cardiotoxicity in 17.4% of cases, and coagulopathy in 4.3%. No patient discontinued therapy due to adverse events. The best treatment results were achieved by patients who used the combination of palbociclib with an endocrine partner as the first line of treatment for advanced stage.

Conclusion. This analysis of real-world data on the use of palbociclib in real-world clinical practice confirms the RCT data on the efficacy and safety of using CDK4/6 inhibitors for the treatment of patients with HR+ HER2- mBC.
Kent Tarihi Monografisine Bir Katkı: Aksaray Şehrinin Mülki İdaresi (1848-1927)
Authors: Aslan Taner
Published: December 2024

Aksaray önemli bir konuma sahip olmasından dolayı tarih boyunca devletlerin cazibe merkezi haline gelmiştir. Birçok devletin egemenliği altında kalması hasebiyle muhtelif isimlerle anılmıştır. Mülki idaresi de egemenliği altına girdiği devletlerin yönetim anlayışına göre belirlenmiştir. Selçuklu, Karamanoğulları ve Osmanlı Devleti dönemlerinde önemine binaen mülki idaresi buna göre tayin edilmiştir. Selçuklu ve Karamanoğulları dönemlerinde sancak merkeziydi. Osmanlı egemenliğine girdikten sonra bir süre sancak olarak idari sistemde yerini aldıktan sonra, kaza durumuna getirilmiştir. Erken Cumhuriyet döneminde ise vilayet konumuna getirilmiştir. Çalışmada, salnameler baz alınarak kent tarihi monografisine katkı sunmak üzere, Aksaray’ın mülki idaresi incelenmiştir.
The «right to hope» of persons sentenced to life imprisonment in Ukraine: is constitutionality achieved?
Authors: Ponomarenko Yurii Anatoliiovych , Tiutiugin Volodymyr Illich , Yevdokimova Olena Volodymyrivna
Published: December 2024

The article focuses on the issues related to the implementation of the right to hope for persons serving a life sentence under the national criminal legislation of Ukraine. According to the legal position initially formulated by the European Court of Human Rights and later supported by the Constitutional Court of Ukraine, this type of punishment is recognized as not violating the human right to dignity or subjecting individuals to cruel and inhuman punishment, provided that the national legislation offers predetermined and realistic prospects for its reduction based on penological grounds. To align the Criminal Code of Ukraine with this legal position, the Law of Ukraine dated 18.10.2022 introduced the necessary amendments.
Critical assessments of the amendments, as formulated in certain scientific studies, as well as subsequent appeals by those sentenced to life imprisonment through constitutional complaints regarding the updated version of Article 81 of the Criminal Code, have called into question whether the reformed provisions of the Criminal Code fully comply with the requirements of the Constitution of Ukraine.
As a result of the study, four arguments are presented to support the view that the current legislative regulation of the right to hope for persons serving life imprisonment in Ukraine is within the standard set by the ECHR and meets the requirements of the Constitution of Ukraine. On this basis, it is argued that there is currently no need to align Part 3 of Article 81 of the Criminal Code with the Constitution, and that all constitutional complaints regarding its content may be dismissed by the Constitutional Court of Ukraine not only on procedural but also on substantive grounds. At the same time, the authors do not rule out the possibility of formulating, based on the practice of applying the current two-stage mechanism of release from life imprisonment, the grounds for direct release from life imprisonment in future criminal legislation.
Probation supervision as a type of punishment under the criminal law of Ukraine.
Authors: Ponomarenko Yurii Anatoliiovych
Published: December 2024

The article is devoted to the dogmatic analysis of the provisions on probation supervision as a new type of punishment under the criminal law of Ukraine. Using the previously proposed algorithm for studying each individual type of punishment, the author consistently examines such characteristics of probation supervision as: the content of its legal restrictions; concept; duration; the range of persons to whom it may be applied; peculiarities of its establishment in sanctions; peculiarities of appointment; peculiarities of appointment to minors; peculiarities of substitution; peculiarities of release from probation; impact on the expungement and removal of a criminal record; criminal liability for evasion of probation supervision.
Based on the results of the analysis, the author describes each of these characteristics of probation supervision and shows the systemic links between the provisions on this type of punishment and other provisions of the Criminal Code of Ukraine. The author emphasises the need to abandon the use of this type of punishment in sanctions for serious crimes, as well as in sanctions for criminal offences for which probation is not allowed. The author formulates recommendations for judicial practice regarding the application of probation supervision when it is imposed for a single criminal offence, as well as for a combination of criminal offences or a set of sentences.
The article also describes the possibilities of using probation supervision as a substitute or commutative punishment on all grounds provided for by the Criminal Code, as well as the possibilities for release from probation under each ground provided for by the Criminal Code. The author identifies the peculiarities of expungement of a criminal record for persons who have served a sentence in the form of probation supervision. For the first time in the literature, the author examines the issue of criminal liability for evasion of probation supervision and provides an interpretation of all elements of the criminal offence under Part 3 of Article 389 of the CC.
Based on the results of the study, the author identifies and describes a number of legislative shortcomings in the legal regulation of probation supervision and suggests ways to address them.
How to qualify banditry: Does truth arise from argument?
Authors: Azarov Denys Serhiiovych , Marin Oleksandr Kostiantynovych
Published: December 2024

In the literature and court practice, two opposing viewpoints exist on the qualification of attacks committed as part of a gang or jointly with it. According to the first one, the attacks are fully covered by the elements of banditry and do not require additional qualifications. Proponents of the second approach consider it necessary to qualify all attacks separately and charge banditry itself. The first approach is more common in scientific publications, while the other appears in court practice.
The authors hold different views on the qualification of banditry, which distinguishes this article from other co-authored publications. In a polemical manner, each author presents and justifies his legal position on qualifying banditry and invites the reader to decide which position deserves to prevail. The relevant issues are examined through the prism of several principles, including the non bis in idem principle, the in dubio pro reo principle, legal certainty, and the completeness and accuracy of criminal qualification. The authors point to the differentiation of responsibility, the multiplicity of crimes, the so-called composite corpus delicti, and the "absorption" of one corpus delicti by another. In addition, the article provides a brief analysis of court verdicts under Article 257 of the Criminal Code of Ukraine, available in the Unified State Register of Court Decisions, and illustrates the significant shortcomings of this register.
The difference in approaches to applying criminal law does not preclude the consensus on the future of criminal law proposed in the conclusions.
Design and Implementation of Siprakfis (Physics Laboratory Practical Management Information System) to Optimize Practical Services in Higher Education
Authors: Widyastuti Widyastuti , Rofiudin Muhammad , Rohim Ahmad Minanur
Published: December 2024

Physics laboratories often face difficulties managing practicums, especially in scheduling, equipment tracking, assessment, and evaluation of practicum results. The mismatch between practicum needs and resource availability usually results in delays, administrative errors, and increased workload of laboratory staff. This study proposes the development of a Physics Laboratory Practicum Management Information System (SIPRAKFIS) to optimize practicum management in physics laboratories. The research method used is R&D with a waterfall development model, which includes communication, planning, modeling, construction, and deployment stages. SIPRAKFIS was developed using the PHP MySQL programming language. System testing was done through unit testing, functionality, usability, and implementation. The study results indicate that SIPRAKFIS is feasible to use in practicum management and can be accessed online via www.labfisikauin.com. Unit testing on the login system was declared victorious. Functional testing obtained good results, namely a functional value of 1. Usability testing obtained a value of 82.59%. Deployment testing showed that the system can be run on various browsers, namely Mozilla Firefox, Google Chrome, and Internet Explorer. SIPRAKFIS can help facilitate the management of practicum services, reduce administrative errors, speed up the practicum scheduling process, and facilitate equipment monitoring and reporting of practicum values. The results of this study can also be further developed for research and testing services.
METİLEN MAVİSİ BOYAR MADDESİNİN SENTETİK ATIKSULARDAN Cu-Alg HİDROJEL BONCUKLAR KULLANILARAK UZAKLAŞTIRILMASI
Authors: Akyüz Lalehan , Sönmez Gamze
Published: December 2024

Son zamanlarda su kirliliğinde meydana gelen artış, artan çevresel endişeleri de beraberinde getirmektedir. Bu nedenle kirleticilerin sulardan uzaklaştırılması hem çevresel hem de insan sağlığı açısından gün geçtikçe önem kazanmaktadır. Kirleticilerin sulardan uzaklaştırılması için uygulaması kolay ve düşük maliyetli bir yöntem olan adsorpsiyon prosesi yoğun olarak kullanılmaktadır. Adsorpsiyon prosesinde kullanılacak adsorbanların tasarımı ve geliştirilmesi ise araştırmacılar arasında büyük ilgi görmektedir. Bu adsorbanlardan biri de aljinat bazlı hidrojel boncuklardır. Bu çalışmada bakır (II) iyonları ile çapraz bağlanarak elde edilen aljinat hidrojel boncuklar metilen mavisinin sudan uzaklaştırılması için kullanılmıştır. Sodyum aljinat ile bakır (II) iyonları çapraz bağlanarak Cu-Alg adı verilen aljinat hidrojel boncuklar sentezlenmiş ve FTIR ile karakterize edilmiştir. Cu-Alg adsorban olarak kullanılarak kesikli adsorpsiyon prosesi ile metilen mavisinin sudan uzaklaştırılmasına adsorban dozu, pH, sıcaklık, temas süresi ve boya konsantrasyonunun etkisi araştırılmıştır. Denemeler sonucunda 0,1 g/50 mL adsorban dozu, 12 pH seviyesi, 30°C sıcaklık, 120 dakika temas süresi ve 10 mg/L metilen mavisi konsantrasyonu optimum koşullar olarak belirlenmiştir. Bu koşullarda, maksimum metilen mavisi giderimi %90,07 olmuştur. Ek olarak, çeşitli kinetik izoterm modelleri kullanılarak Cu-Alg hidrojel boncuklar üzerine metilen mavisi adsorpsiyonunun kemisorpsiyon ve fizisorpsiyon yoluyla gerçekleştiği gösterilmiştir. Termodinamik analiz ile adsorpsiyon sürecinin ekzotermik ve spontan bir yapı sergilediği ortaya konulmuştur.
Current Landscape and Future Directions for Mental Health Conversational Agents for Youth: Scoping Review
Authors: Park Jinkyung Katie , Singh Vivek K , Wisniewski Pamela
Published: December 2024

Background

Conversational agents (CAs; chatbots) are systems with the ability to interact with users using natural human dialogue. They are increasingly used to support interactive knowledge discovery of sensitive topics such as mental health topics. While much of the research on CAs for mental health has focused on adult populations, the insights from such research may not apply to CAs for youth.

Objective

This study aimed to comprehensively evaluate the state-of-the-art research on mental health CAs for youth.

Methods

Following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, we identified 39 peer-reviewed studies specific to mental health CAs designed for youth across 4 databases, including ProQuest, Scopus, Web of Science, and PubMed. We conducted a scoping review of the literature to evaluate the characteristics of research on mental health CAs designed for youth, the design and computational considerations of mental health CAs for youth, and the evaluation outcomes reported in the research on mental health CAs for youth.

Results

We found that many mental health CAs (11/39, 28%) were designed as older peers to provide therapeutic or educational content to promote youth mental well-being. All CAs were designed based on expert knowledge, with a few that incorporated inputs from youth. The technical maturity of CAs was in its infancy, focusing on building prototypes with rule-based models to deliver prewritten content, with limited safety features to respond to imminent risk. Research findings suggest that while youth appreciate the 24/7 availability of friendly or empathetic conversation on sensitive topics with CAs, they found the content provided by CAs to be limited. Finally, we found that most (35/39, 90%) of the reviewed studies did not address the ethical aspects of mental health CAs, while youth were concerned about the privacy and confidentiality of their sensitive conversation data.

Conclusions

Our study highlights the need for researchers to continue to work together to align evidence-based research on mental health CAs for youth with lessons learned on how to best deliver these technologies to youth. Our review brings to light mental health CAs needing further development and evaluation. The new trend of large language model–based CAs can make such technologies more feasible. However, the privacy and safety of the systems should be prioritized. Although preliminary evidence shows positive trends in mental health CAs, long-term evaluative research with larger sample sizes and robust research designs is needed to validate their efficacy. More importantly, collaboration between youth and clinical experts is essential from the early design stages through to the final evaluation to develop safe, effective, and youth-centered mental health chatbots. Finally, best practices for risk mitigation and ethical development of CAs with and for youth are needed to promote their mental well-being.
Modeling the Transport and Deposition of Suspended Solids Under Conditions of Low Water and Surge Phenomena in the Don River Estuary Area
Authors: Berdnikov Sergey , Sheverdyaev Igor , Kleshchenkov Alexey , Kulygin Valeriy , Likhtanskaya Nataliya
Published: December 2024

An approach is proposed for the joint use of the model implemented in the HEC-RAS software and a balance model to describe the transport and transformation of suspended solids in a river delta. In the river estuary region, hydrological areas are distinguished: channel areas, floodplain areas, flooded during high floods and storm surges from the sea, and the delta front areas. For the hydrological areas, a dynamic model of the balance of water and substances transported by water flow is built. Parameterization of the suspended solids sedimentation processes and their resuspension is introduced depending on the speed of water movement and particle size. Three gradations of suspended solids in size are considered: pelitic fraction (clay), alevrit fraction (silt) and fine sand. The emphasis is on assessing the impact of marine storm surges on the transport of suspended solids into the river delta and their deposition. To describe water flows between areas, movement speeds, level dynamics and floodplain flooding processes, a detailed model based on the HEC-RAS software adapted to the conditions of the Don River estuary area is used. Calculations of the transport and accumulation of suspended solids in the Don River estuary area were carried out for two variants of hydrological conditions – with the water surge from the sea and without it. The spatiotemporal variability of the concentration and granulometric composition of suspended sediment depending on hydrological conditions is considered. It is shown that in the absence of surge phenomena and low water flow rates, suspended solids are mainly deposited in the avandelta outside the sea edge of the delta, and during the surge period they saturate the water and, at the stage of rising its level, enter the delta, partially settling in the branches and in the floodplain areas. At the same time, at the stage of the water level decline, they are carried out of the channel segments beyond the sea edge of the delta, and mostly remain in the floodplain areas. For low-water conditions with the observed frequency of surge events and in the absence of floods, the Don estuary area retains on average 20% of suspended solids entering with the Don River runoff.
Research on the Application of College English Club Activities in English Teaching
Authors: Wu Qi
Published: December 2024

College English club activities, as an important form of extracurricular learning, provide students with opportunities to practice their language skills and broaden their cultural horizons. In college English teaching, how to fully leverage the role of club activities to enhance students' comprehensive English application abilities has become a significant topic worthy of attention. This paper aims to explore the effective integration of English club activities with classroom teaching, summarize practical experience through the analysis of specific cases, and provide beneficial references and innovative ideas for college English teaching.
DROTAVERIN VERSUS EPIDOSIN IN CERVICAL DILATION DURING LABOR
Authors: SAILAJA KAZA  , LAKSHMI RENUKAA  , KAMBHAM BHASKAR SUNEETHA
Published: December 2024

Objective: The objective of the study is to compare the efficacy and safety of drotaverine hydrochloride and epidosin on cervical dilatation.
Methods: A total of 80 patients (aged 20–30 years) including both primigravidae and multigravida labor were divided randomly into two groups with 40 patients in each. The drotaverin (D) and epidosin (V) groups were given intravenously, 40 mg drotaverine hydrochloride to the former with every 2 h for a maximum of 3 doses and 8 mg epidosin to the latter with maximum of 6 doses half an hour apart.
Results: The mean duration of active phase of labor (hour) was significantly lower in the drotaverin group compared to epidosin group. Furthermore, the cervical dilatation rate was significantly faster in the drotaverin group. There was a significantly higher probability of faster delivery among women who were given drotaverin. The oxytocin augmentation rate, incidence of prolonged labor, labor pain scores, mode of delivery, and maternal and neonatal outcomes were not significantly different among the groups.
Conclusion: This study concluded that drotaverin is a new aid in the management of a convenient, shorter, physiological, and uncomplicated delivery.
ENDOMETRIAL HISTOPATHOLOGICAL PATTERNS IN PATIENTS WITH ABNORMAL UTERINE BLEEDING: A SIX MONTHS OBSERVATION OF 285 CASES IN A TERTIORY CARE HOSPITAL
Authors: ABHILASHA  , GUNJA DWIVEDI  , ASHISH  , NAVED KHAN
Published: December 2024

Objectives: the objective of the study was to assess the histopathological patterns of endometrial lesions in patients with abnormal uterine bleeding (AUB) across different age groups.
Methods: A descriptive cross-sectional study was conducted over 6 months at RNT Medical College, Udaipur after the approval of the Institutional Ethics Committee. A total of 285 cases presenting with AUB were analyzed through clinical history, physical examination, and endometrial biopsy. Cases were categorized into reproductive, perimenopausal, and postmenopausal groups for comparative analysis.
Results: The perimenopausal group had the highest incidence of AUB (50.88%). The most common histopathological findings included secretory (39%) and proliferative (31%) phases. Senile cystic atrophy was prevalent in postmenopausal women (38.71%), while endometrial hyperplasia was observed more in perimenopausal and postmenopausal women. Malignant cases, including adenocarcinoma, were rare but significant, particularly in the postmenopausal group.
Conclusion: Age-specific variations in endometrial patterns highlight the influence of hormonal changes and the increased risk of malignancy in postmenopausal women. The findings support the importance of endometrial histopathological evaluation in managing AUB, especially in perimenopausal and postmenopausal patients to identify potentially precancerous conditions.
COMPARISON OF SEVOFLURANE AND ISOFLURANE ON HEMODYNAMICS AND RECOVERY CHARACTERISTICS IN GERIATRIC PATIENTS UNDERGOING LAPAROSCOPIC CHOLECYSTECTOMY
Authors: VISHALDEEP SINGH  , PARMOD KUMAR  , TRIPAT KAUR BINDRA  , JAGJIT SINGH  , SIMRIT KAUR  , LALIT KUMAR GARG
Published: December 2024

Objective: The aim of the present study was to compare sevoflurane and isoflurane on hemodynamics and recovery characteristics in geriatric patients undergoing laparoscopic cholecystectomy (LC).
Methods: The prospective, comparative, and randomized study was conducted on a total of 80 patients aged above 60 years of either sex and American Society of Anesthesiologists physical status I and II who were scheduled for elective LC under general anesthesia in Government Medical College, Rajindra Hospital, Patiala.
Results: Patients were hemodynamically stable throughout the surgery in both the groups but the emergence and recovery were significantly faster in the sevoflurane group. The sevoflurane group showed a faster time to spontaneous breathing, time to eye-opening, response to verbal commands, extubation time, and early orientation of the patient.
Conclusion: Sevoflurane might be considered a useful alternative to isoflurane in providing anesthesia in laparoscopic cholecystectomies, especially in elderly patients where rapid emergence and recovery are very much desired along with stable hemodynamic parameters.
Human-AI Collaboration Models: Frameworks for Effective Integration of Human Oversight and AI Insights in Business Processes
Authors: Frenette Joel
Published: December 2024

Purpose: This paper proposes structured frameworks for effective Human-AI collaboration within business processes.
It aims to identify and model optimal task divisions where humans contribute oversight, creativity, and strategic judgment while
AI provides computational power, automation, and analytical insights.
Methodology: We explore collaboration models based on role-based division, process integration, and task adaptability. We
analyze real-world business applications to demonstrate the efficacy of these models in improving productivity, decision-making,
and innovation.
Findings: We propose three key frameworks: (1) Augmented Creativity, where AI enhances human ideation, (2) Hybrid Decision
Systems, where AI assists human judgment through predictive insights, and (3) Oversight-Driven Automation, where humans
maintain control over automated tasks.
Implications: The study highlights pathways for achieving synergistic Human-AI interactions to optimize business outcomes,
enhance agility, and ensure ethical AI deployment
Modelling, Analysis and Fabrication of CNC Crankshaft for Single Cylinder for 100CC Four-Stroke Engine
Authors: Niranjan T. , Babu P.Ramsai Diwakar , Sevya Vadthya , Reddy Sai Prasad , Kumar Santhosh
Published: December 2024

Abstract: This paper presents an integrated methodology for the development of an advanced crankshaft, incorporating
SolidWorks for modelling, ANSYS for analysis, and CNC milling for manufacturing. SolidWorks facilitates the exploration of
innovative design parameters, including material selection and stress analysis, while ANSYS ensures comprehensive structural
and dynamic analyses. The optimized design is seamlessly translated into the manufacturing phase, utilizing CNC milling
technology for precision machining operations. The CNC milling process, guided by the SolidWorks model, ensures exceptional
dimensional accuracy and surface finish, contributing to the production of a high-performance crankshaft. This work further
includes a modification phase, informed by insights from ANSYS analyses, aimed at strategically enhancing the crankshaft's
mechanical properties. Rigorous testing validates structural integrity and overall functionality. This integrated approach offers a
synergistic solution for engineers and manufacturers, showcasing the seamless collaboration between design, analysis, and
manufacturing. The outcomes contribute to the advancement of crankshaft technology, providing a blueprint for optimizing
engine performance through a holistic and technologically advanced approach
The Impact of Organizational Justice on Job Satisfaction: A Computational and Experimental Analysis in Workplace Systems
Authors: Chella Supriya , Sundari Dadhabai
Published: December 2024

Employees play a vital role in   organization growth and development. This aims to understand the relationship between employee job satisfaction and organization justice. It has been a key component to product better outcomes in an organization and productivity in the organizations .The present research tries  to examine the various dimensions of organizational justice on employee job satisfaction in Information Technology (IT) industry. Responses from IT employees were obtained using a structured questionnaire based on well established scales. Respondents for the study were chosen from IT (Information Technology) industry from Hyderabad metro city based on convenience sampling method. A total of 88 responses were obtained for full scale data analysis. We applied multiple regression analysis to analyze the data. SPSS software was used to analyze the data. The results of the study proved that various dimensions of organizational justice exerted a positive influence on job satisfaction.
Constructing a Buddhist Infrastructure: Nationalist Politics and the Transformation of Buddhism in Contemporary Vietnam
Authors: Nguyen Dat Manh
Published: December 2024

Since the late 2000s, anti-China sentiments have increased across Vietnam, with large public protests against China’s encroachment in the ‘South China Sea’ or the ‘East Sea’. Such sentiments have raised important questions about Vietnamese sovereignty and cultural identity . Among Buddhists, the ‘China’ question has motivated endeavours to construct a ‘Vietnamese’ Buddhism that maintains a critical distance from ‘Chinese’ religious influences. Based on extensive fieldwork in Vietnam, this paper examines Vietnamese Buddhism as a form of soft power, particularly its ability to shape public understanding of Vietnamese identity and geopolitics. In analysing a few initiatives linked to a prominent Buddhist temple in Ho Chi Minh City, including a Buddhist public health campaign to promote organ donations and the organisation of the United Nations Day of Vesak, I explicate the intense efforts by Buddhists to create a religious infrastructure aimed at broadening the scope of Buddhist influence on Vietnam’s public life and international diplomatic relationships. I argue that this emerging Buddhist infrastructure signals transformations within Vietnamese Buddhism as it becomes increasingly entangled with local and transnational socio-political concerns.
Assessment of water quality in Yapialtin Dam Lake (Sivas, Turkey) during dry and rainy seasons using various parameters and water quality indices
Authors: Divrik Menekşe
Published: December 2024

There are many dam lakes in the ?ark??la district of Sivas, where
agricultural activities are intense. Yap?alt?n Dam Lake, which constitutes
our study area, is one of them. The research was conducted at three stations
in Yap?alt?n Dam Lake during the dry season in August 2023 and the rainy
season in May 2024. Eighteen physicochemical variables of lake water were
measured. The quality of dam lake water was assessed using indices such as
the Eutrophication Index (EI), Organic Pollution Index (OPI), Nutrient
Pollution Index (NPI), and Water Quality Index (WQI). The similarity of the
stations in terms of physicochemical parameters was determined using
Bray-Curtis similarity analysis. Additionally, Pearson and Spearman
correlation analyses were employed to examine the relationships among the
physicochemical data. The analyses revealed seasonal variations in all water
quality indices.In conclusion, the study provides recommendations for the
sustainable use of the dam lake.