bluuebunny/crossref_metadata_2025 huggingface dataset:
Patterns Of Educational Interaction in the Formation of Multicultural Attitudes of Students in Multi Religious Schools
Authors: Gafur Abd
Published: January 2023

This study aims to describe the pattern of educational interaction that was built at Taman Harapan Elementary School, Malang City. This research approach is qualitative and contains one type of case study. On the Other Hand, the researcher examines interesting and unique things from the implementation of learning carried out in multi-religious schools (Taman Harapan Elementary School) which focuses on aspects of learning interaction patterns developed by teachers so that they can form a multicultural attitude. To dig up data and information related to this research activity, data collection techniques, participant observation, in-depth interviews, and document analysis will be used. Meanwhile, the data analysis technique using the interpretive approach refers to the interaction model of Milles, Huberman, and Saldana including 3 techniques; (1) data condensation, (2) data display, and (3) conclusion drawing/verification. After carrying out these stages, they then will be described in such a way that conclusions and research findings related to the pattern of educational interaction applied in Taman Harapan Elementary School, Malang City are obtained. The results of this study indicate that the educational interaction model in forming the multicultural attitude of Taman Harapan primary school students is realized through the construction of three models. The interaction between educators and multi-faith students on learning objectives, materials, and methods. First, educative interaction on learning objectives developed through analysis of multicultural values in the curriculum and school institutional goals. Secondly, educational interaction with learning materials. This interaction is built through a culture of values in the course content taught by the teacher and the reference books used. Third, the educational interaction on the teaching method developed by the teacher in the classroom. Includes the use of learning methods that can enable communication and communication between students and teachers, teachers and students, students and students based on multicultural values, respecting diversity and differences, tolerance, and openness.
The Development of Teaching Materials Based on Project-Oriented TPACK Approach to Improve the Creative Thinking Skills of Elementary School Teacher Prospective Students
Authors: Rahayu Galih Dani Septiyan , Altaftazani Deden Herdiana , Wardani Duhita Savira
Published: January 2023

This study aimed to produce project-oriented TPACK-based teaching materials (Technology Pedagogical Content Knowledge) that can improve the students’ creative thinking skills of elementary school teacher prospective students. This research used development research method (RnD) which was adapted from Borg & Gall. There were 10 Borg & Gall development procedures which are modified into 8 stages which were adapted to the conditions in the field. The results showed that the project-oriented TPACK-based teaching materials were suitable for use in learning with valid, practical, and effective criteria. The validation results from the average value of the expert validator of teaching materials and learning technology media show that teaching materials are considered valid both in terms of construct and content. Observations on the activity of lecturers and students which increased at each meeting indicated that practical teaching materials were applied in learning, as well as the results of students' creative thinking skills tests showed that teaching materials were effective in increasing the students’ creative thinking skills of prospective teacher. The implication of this research is the use of the right method can affect the achievement of creative thinking skills of students to be able to propose various alternative problem solving. The suggestions for further research are developing project-oriented TPACK-based teaching materials for elementary school students.
The Elementary School Students’ Thinking on Islamic Moderation: Tracing the construction of the NU Elementary School’s Curriculum in the regency of Kediri
Authors: Yasin Muhamad , Khasbulloh Muhammad Nabil
Published: January 2023

Elementary schools were a group that was strongly influenced by the values of religious radicalism, then how elementary schools were able to transmit moderation and internalize it to students, considering that so far, the study of Islamic moderation had not seriously targeted the world of basic education. The object of this research was to examine the NU Elementary School of Insan Cendekia Kediri by using a qualitative sociological phenomenological research method. This study produced Islamic moderation reasoning through the construction of an Islamic elementary school curriculum, as follows: First, the understanding of ahlusunnah wal jama'ah (aswaja) was used as the basis for curriculum preparation, the school integrates the 2013 curriculum and the Ma'arif NU curriculum, schools implement an integrated activity-integrated curriculum system, thus enabling parents and teachers to carry out education together; Second; Internalization was done by combining academic education, religion, skills, and attitudes. In the learning process, the Elementary School of NU Insan Cendekia Kediri combines various learning methodologies, as well as child-friendly schools, character-based learning, instilling school culture, and religious learning applications. For this reason, in practice, many things at school prioritize an attitude of being moderate (tawwasut), tolerant (tasamuh), not extreme, balanced (tawazun), and always taking a consistent attitude (i'tidal) as the basis for developing Islamic moderation reasoning in schools. The curriculum implemented by NU elementary schools could shape Islamic moderation reasoning. This could be seen from the formation of the moderate character of students during activities at school. As well as the commitment of all school members to be a very important factor in realizing students with moderate Islamic ideological characteristics.
Application of Bingo Media Based on Local Wisdom in Training Vocabulary Mastery of Indonesian Learning Class III MI NU Bahrul Ulum Kudus
Authors: Hanik Elya Umi , Aini Anni Qurrotul
Published: January 2023

information. The purpose of this study was to determine the application of local wisdom-based Bingo media in practicing vocabulary mastery for class III Indonesian subjects at Islamic Elementary School (MI) NU Bahrul Ulum Kudus. The approach of this research used qualitative field research. The data collection techniques used were observation, interviews with school principals, third-grade teachers, and third-grade students as well as through documentation. The results showed that the application of local wisdombased Bingo media at MI NU Bahrul Ulum Kudus began with the creation of Bingo media. Preparation of materials for 9 local Kudus foods continued with the process of implementing learning using Bingo media by means of students answering the questions on the Bingo question cards, if they succeeded in answering 3 Bingo question cards in sequence, they were entitled to shout the word “Bingo!”. Student evaluation activities include learning outcomes to meet the minimum complete criteria KKM, the willingness of students and telling stories based on certain vocabulary, and found supporting factors
The Numeracy Competency Profile of Elementary School Teachers in Ponjong District, Gunungkidul Regency Viewed from Demographic Factors
Authors: Prananto Irfan Wahyu , Purnomo Yoppy Wahyu , Firdaus Fery Muhamad
Published: January 2023

This study aims to describe the numeracy competency profile of elementary school teachers in Ponjong District, Gunungkidul Regency, viewed from demographic factors. The demographic factors used to describe, there were gender, type of school (public or private), length of teaching, age, and whether the teacher in question was certified as an educator. This numeracy competency was essential to explore because this skill was one of the most critical primary education goals; it helped realize successful advanced learning, social interaction, meeting the necessities of life, and global employment. This study used a design-based research (DBR) approach combined with professional learning community (PLC) and participatory action research (PAR), in which a sample of forty teachers was drawn equally from each group of teachers working groups (KKG). The data were taken using test instruments and analyzed using inferential statistical tests. The results showed that from the gender aspect, there was no difference in numeracy competence for both men and women. The second, based on the type of school, there was no difference in numeration competence between public and private schools. The third, from the length of teaching, it was found that teachers with a duration of education under five years had a higher numeracy score. The fourth, in terms of age, there was no difference in numeracy ability from twenty-five to fifty-six years. The conclusion, from the aspect of educator certification, was fascinating. Although not significant, there was an average difference in the numeracy ability test between teachers who were certified educators and those who were not certified, where teachers who did not have an educator certificate had a higher test average than those who already had an educator certificate.
The Concept of Elite (Thoughts of Antonio Gramsci and the Study in Islamic Studies)
Authors: Amaliyah Efa Ida , Nurhadi Agus
Published: January 2023

This study attempts to reveal the elite concept from Antonio Gramsci's thought which supports elite studies in an Islamic perspective, by using library research methods. The elite according to Gramsci is a social category that is not related to class but related to hegemony. Hegemony is a winning power that is obtained through a consensus mechanism rather than through violence or oppression of other social classes. The regime spreads hegemonic power of influence because it is supported by related infrastructure organizations, namely in which intellectual obedience is supposed to occur due to cultural and political factors. This is where elites emerge which are categorized into two according to Gramsci, namely organic elites (politicians, bureaucrats, academics) and traditional elites (subject to authorities). Elites in Islam bring consequences or impacts by showing the importance of elite positions in the orderliness of civilization, the urgency of elite cadre formation in order to strengthen faith and belief as well as faith. This is important to do because of the vital role played by the elite for the advancement of society around them. Therefore, the religious elite, the religious elite, now have an obligation to participate in realizing national unity and are responsible for maintaining national resilience in its various aspects (ideological, political, economic, and socio-cultural)
Analyze of Dramaturgy to Self Concept of Pupil TMI Al-Amien Prenduan (Erving Gofman’s Theory Analysis)
Authors: Nisak Khoirun , Salimah Ifa Dotus , Ma’ruf Amar , Syaifuddin Syaifuddin
Published: January 2023

Human social life always be related with society interacting anywhere, anytime, and their lives present their selves as a theatre performers whose appearance can change at any time depending on the context. It happens in human life, whoever we are, and in any condition, we always interact in symbols. Maybe without us realizing it, it all happens in every "scene", in a "play" of life. This research uses descriptive analysis, using an interpretive paradigm. By starting from the phenomenon being studied to produce a theory, the goal is used to understand the meaning of the experience of a person, group. But education that can be drawn from the vile events that a person has gone through. By analyzing from sources that are directly on the object and relevance to research. Reviewing the self-presentations displayed by the students by looking at the backstage and front stage. The results of this analysis, the students of TMI Al-Amien Prenduan in their daily lives can manage the two allocations of the place, they know their position how they must display their character setting in front of the supervisors of the cottage, and position their original character when behind the supervisor of the cottage when they are free from supervision.
Cultural Value in The Ati Kebo Seunduhan Tradition Marriage of Demang Aryareja’s Development in Grantung Village, Purbalingga
Authors: S Anissa Pristianingtyas , Birsyada Muhammad Iqbal
Published: January 2023

This study aims to determine: (1) The history of the tradition of Ati Kebo Seunduhan at the marriage of the descendants of Demang Aryareja in the village of Grantung, Purbalingga. (2) The process of implementing the tradition of AtiKebo Seunduhan at the marriage of the descendants of Demang Aryareja in the village of Grantung, Purbalingga. (3) Cultural value contained in the tradition Ati Kebo Seunduhan at the marriage of the descendants of Demang Aryareja in the village of Grantung, Purbalingga. The method used in this research is a qualitative research method with a descriptive approach. In this study, there are two types of data and data sources, namely primary data obtained through interviews and secondary data in the form of books, journals and theses. Data collection techniques used are observation, interviews and documentation. Data analysis techniques used are data collection, data reduction, data presentation, conclution and verification. The technique of checking the validity of the data used was source triangulation and theory triangulation. The result of this study indicate that: (1) The history of the tradition of AtiKeboSeunduhan on the marriage of the descendants of DemangAryareja has been carried out since the 19th century. (2) The process of implementing the Ati Kebo Seunduhan tradition begins with the purchase of buffalo hearts by men, the delivery of Ati Kebo Seunduhan to Demang Aryareja Cemetery and the distribution of Ati Kebo Seunduhan to relatives and neighbors. (3) The cultural values contained in the Ati Kebo Seunduhan tradition are the values of togetherness, kinship, and mutual cooperation.
Mappadendang Tradition in Efforts to Preserve The Environment in Parepare Communities of Indonesia
Authors: Zahrawati Fawziah , Andriani Andriani , Natasya Natasya , Syarah Indri , Yuniar Yuniar
Published: January 2023

This study aims to examine the existence of the Mappadendang tradition of the Parepare community in Indonesia, implementing the Mappadendang tradition, and the Mappadendang tradition related to environmental conservation efforts. A qualitative approach is used to answer the research objectives. This research was conducted in Watang Bacukiki, Parepare City, Indonesia. Informants in this study are the people who live around the research location and take part in carrying out the Mappadendang tradition. The data collection techniques are interviews and documentation. After the data is collected, the data is analyzed. This study found that the Mappadendang tradition has been implemented since the community has been familiar with agriculture and the tradition still exists today. Implementing Mappadendang tradition includes rice mashing activities, dances, and eating together. The Mappadendang tradition cannot be separated from efforts to preserve the environment. This can be seen from the activities of cleaning the environment together and the stipulation of rules not to litter and to carry out activities that do not damage the environment. From the findings of this study, it can be concluded that the Mappadendang tradition, as a tradition passed down from generation to generation, must be preserved because implementing the tradition is closely related to environmental conservation efforts.
Muhasabah Through Self Talk Techniques to Reduce Students' Anxiety in Completing The Thesis
Authors: Jawandi Ahmad , Putro Eko Adi
Published: January 2023

Negative anxiety can make students lazy in doing thesis, lose motivation, and even delay completing it. The main objective of this research is to reduce students' anxiety in completing the final project through reflection with the Selftalk technique. The research method uses an experiment with a "non-equivalent group pretest-posttest control design" design. The sample in this study came from FKIP UNISRI students who were taken using purposive random sampling technique. The data analysis technique used the Wilcoxon test formula. The significance value of the experimental group is 0.005 < 0.05, then Ho is rejected and Ha is accepted, meaning that reflection through self-talk techniques is effective in reducing student anxiety in completing the final project.
Analisis Human Security dalam Resolusi Dewan Keamanan Persatuan Bangsa-Bangsa (DK PBB) No. 2334 Tahun 2016
Authors: Hata Zulva Talida , Wijayanti Sri
Published: January 2023

UN Security Council resolution no. 2334 is issued to resolve the conflict between Palestine and Israel. This resolution contains orders for Israel to halt the expansion of settlements and to stop the demolition of Palestinian homes. Basically, the resolution aims to defuse conflict and to create peace in the region. The expected peaceful situation will affect security for humans. Therefore, this paper will analyze UN Security Council resolution no. 2334 with a human security approach. This paper finds that UN Security Council resolution 2334 fulfilled the indicator of human security approach because the resolution urges the parties to comply with the laws of Geneva Convention IV, international humanitarian law, the opinion of the International Court of Justice, the Quartet Roadmap, as well as many previous resolutions. All international instruments that are mentioned are focused on discussion to protect human in economic, food, health, environmental, personal, community, political and human rights. However, in practice, this resolution met many obstacles, and even tended to be ignored by Israel. This paper uses a descriptive qualitative method with data collection techniques carried out through a literature review.
Negara Adil dan Makmur (Refleksi Filsafat Politik Al-Ghazali)
Authors: Ulum Ahmad Manbaul
Published: January 2023

This research is motivated by the geopolitical situation in various countries where in fact there are still many countries that act arbitrarily against their citizens. This article aims to describe Al-Ghazali's political thought which explains about good governance according to Islam, how to be an equitable leader. Then explain in detail about the basics of justice that must be owned by a leader of the State. The method of this research is library research. The primary data is sourced from Al-Ghazali’s book related to political perspective, such as Political Ethics which is a translation of Al-Tibru Al-masbuk Fi Nashihat Al-Muluk. Meanwhile the secondary data is sourced from journals, articles, and documents that related to this research. The result of this research is Al-Ghazali formulated ten principles of justice that must be possessed by a leader, including : recognizing the value of power along with the risks and dangers; the ruler must be happy and like to ask for advice from scholars; moved to eradicate injustice; humble/not arrogant; aware that the ruler/leader is basically also the people; likes to help/cares for the people; qonaah/no luxury; gentle; loves the people; does not violate the shari'ah.
Kebijakan Pemerintah terhadap Front Pembela Islam (FPI) Pascaperistiwa 212 Tahun 2016-2021
Authors: Putri Gustri Eni
Published: January 2023

This study  discussed the policies of the Indonesian government in dealing with the Islamic Defenders Front (FPI)  after the events of 212 from 2016 to 2021. The purpose of this study is to understand the state's attitude towards these movements, both in terms of repression strategies and tactics used to suppress social movements. , because of that the government carried out repression against FPI after the incident. year 212. Meanwhile, the method used in this paper is a case study type or model as part of a qualitative research using the concept of state repression against FPI after the events of 212. The data to be used is through a literature study from books, journals, and media reports, as well as official sources belonging to the government and social movements that are the object of study in this research. In reviewing state policy towards the Islamic Defenders Front movement, Boykoff's approach. The results of this study are the Jokowi government's policy of carrying out a repressive strategy against the FPI to drain resources (resource depletion) by committing violence against activists, detaining, and making extraordinary, stigmatizing, and intimidating rules and laws.
Keterlibatan Perempuan dalam Perang, Politik dan Non-Politik Menurut Perspektif Islam (Studi Kasus: Perlawanan Perempuan Palestina terhadap Okupasi Israel Tahun 2000-2019)
Authors: Rachmawati Tety , Karisma Gita , Mumtaz Sonya
Published: January 2023

Israel's occupation of Palestine led to resistance by the Palestinian people from all over the country. This struggle is not only carried out by men but also women. In the Islamic perspective, women and men have the same position, there is no discrimination between them. This paper aims to explain the resistance of Palestinian women to Israeli occupation based on an Islamic perspective. The research used qualitative methods through literature study. The results of this research indicate that the Palestinian women's resistance emphasizes the equal position of men and women in Islam. Islam does not limit the roles and activities of women. In conflict situations, women are allowed to participate in war and also in politics. Resistance of Palestinian women to Israeli occupation is carried out in two ways, namely direct and indirect resistance. The direct resistance is carried out by Palestinian women through war and politics. Meanwhile, indirect resistance is carried out by providing education for children about the values of the Islamic struggle.
The Politics of the Transition of the Hagia Sophia to a Mosque by President Recep Tayyip Erdogan
Authors: Mujahidin Saekul
Published: January 2023

Hagia Sophia is one of the UNESCO world heritage sites built by Emperor Justinian I which is a Basilica building in Istanbul Turkiye and is a conflict between two religions, namely Christianity and Islam. In 2020 a decision that shocked the world came from President Recep Tayyip Erdogan who turned the Hagia Sophia into a mosque that was previously a museum during the time of Mustafa Kemal Ataturk. This paper uses library research, which identifies data including books, journals, articles, and more. The results of the study explain that the status of Hagia Sophia in Istanbul belongs to Turkish state law, not international law, so the Turkish president has the right to change the status of Hagia Sophia into a mosque that was once a museum during the secular regime. Mustafa Kemal Ataturk and other countries should not protest the decision. that. that. According to research from the Istanbul Economic Research Institute last June, 46.9% of respondents agreed with the transformation of the Hagia Sophia into a mosque, while 38.8% of respondents refused and wanted the Hagia Sophia to remain a museum.
Organisasi Perempuan sebagai Agen Sosialisasi Politik di Kabupaten Kudus (Studi Kasus: Fatayat dan Nasyiatul Aisyiyah)
Authors: Dewi Nevy Rusmarina
Published: January 2023

The interest of women in Kudus in joining women's organizations is quite high, among these organizations are Fatayat and Nasyiatul Aisyiah (NA). Although participation in organizations is quite high, participation in political life is still not maximized. This can be seen in the absence of female legislative members and the absence of female regents in Kudus. This study discusses the role of women's organizations in Kudus, especially Fatayat and Nasyiatul Aisyiyah in carrying out political socialization for women in Kudus. The research method used is qualitative-descriptive. The results showed that Fatayat and Nasyiatul Aisyiyah were still less than optimal in conducting political socialization
Normalisasi Hubungan Diplomatik Uni Emirat Arab – Israel: Analisis Rasionalitas Kebijakan Politik Luar Negeri Uni Emirat Arab
Authors: Ahmadi Sidiq , Bumi Jasmine Armantyas Safannah
Published: January 2023

The foreign policy of the United Arab Emirates (UAE) to normalize relations with Israel in 2020 has caused controversy and sparked widespread criticism, especially from Muslim countries, because it is considered to have violated the 2002 Arab Peace Initiative agreement and betrayed a commitment to support Palestine. This article is aimed to analyze the rationality of the UAE's decision mentioned above. This is qualitative research with library research methods. The analysis was carried out using the Rational Actor Model from Graham T Allison. This research found that the decision of the United Arab Emirates to normalize relations with Israel is rational. This option is calculatedly the most beneficial for achieving the United Arab Emirates' national interests, namely, increasing its defense and security sector from Iranian threats, maintaining economic stability, and strengthening its position in the international system.
Pertarungan Narasi Islam dalam Pemilihan Presiden Tahun 2019
Authors: Aswar Hasbi , Zamzami Fauzi Wahyu , Widjayanti Alifya Kasih , Priyansyah Ahmad
Published: January 2023

The 2019 general election is one of the most intense elections in Indonesia's history, especially after reformasi (political reform) in the 1998. This election did not only involve political parties in the fight for the presidency but also involves opposition movements, especially the Islamic movement. After the phenomenon of 212 in 2016, Islamic movements became very active in influencing political activities in Indonesia, including the elections held in 2019. The efforts of this Islamic opposition movement were to delegitimize the regime (Joko Widodo) who tried to participate in the 2019 re-election through various narratives including religious narratives in it. Meanwhile, on the other hand, there are also other Islamic groups that carry out counter-narratives and support Jokowi to be re-elected in the 2019 election. This study focuses on discussing the narratives and counter-narratives carried out by Muslim opposition and pro-regime Islamic groups in the 2019 elections through narrative analysis in qualitative research. Data is collected through online sources, both from those with affiliation with related movements and other media. This research found that there were two sides of the Islamic narrative in the 2019 presidential election, namely the Islamist side who criticized the incumbent presidential candidate and the Islamic group side who supported the presidential candidate as well as the president who was in power.
Анализ динамики эпидемического процесса COVID-19 в мире за неделю с 21.01.2023 г. по 27.01.2023 г.
Authors: Зимирова Анастасия , Поспелов Михаил , Иванова Александра , Дмитриева Людмила , Чумачкова Елена , Карнаухов Игорь , Щербакова Светлана , Кутырев Владимир
Published: January 2023

В обзоре представлен анализ эпидемиологической ситуации в странах мира по COVID-19 за неделю с 21.01.2023 г. по 27.01.2023 г.
ARMADILLO OSTEODERMS ALTERED BY DIGESTION AND HOW TAPHONOMY CAN HELP TAXONOMY
Authors: TOMASSINI RODRIGO L. , MARIN-MONFORT M. DOLORES , GARCÍA-MORATO SARA , MONTALVO CLAUDIA I. , BARASOAIN DANIEL , ZARACHO ELBA M. , CHATELLENAZ MARIO L. , GARRONE MARIANA C. , ZURITA ALFREDO E. , FERNÁNDEZ-JALVO YOLANDA
Published: January 2023

Diverse modifications of the original morphological features occur throughout the taphonomic history of osteological remains, which may lead in erroneous interpretations about the formation of an accumulation as well as taxonomic misidentifications. Here, we present a neo-taphonomic study in order to analyze and interpret the modifications generated by digestion on osteoderms of the armadillo Dasypus novemcinctus obtained from scats produced by Puma concolor. Results reveal intense breakage and modifications of the articular and broken edges, dorsal surface, bone tissues, and ornamentation pattern of the osteoderms. This work describes for the first time the modifications caused by digestion in armadillo osteoderms, improving the knowledge of preservation of this type of skeletal element and providing a modern analog that can be used to distinguish archeological and paleontological accumulations formed by predators from those generated by other processes. The recognition that digestion modifies the original ornamentation pattern is particularly significant because ornamentation features are used in nearly all taxonomic and phylogenetic studies of fossil cingulates. We use this new information to re-evaluate osteoderms recovered from carnivore coprolites of the classic Middle Miocene La Venta site (Colombia), which formed the basis for recognizing and characterizing the dasypodid species Nanoastegotherium prostatum. We highlight the importance of knowing with certainty the origin and taphonomic history of remains since, in the particular case of cingulates, taxonomic identification also has important biostratigraphic, paleoecological, paleoenvironmental, and paleobiogeographical implications.
Data and script to reproduce the results presented in: Evaluation of the extraction of methodological study characteristics with JATSdecoder
Authors: Böschen Ingmar
Published: January 2023

This protocol contains the data and R script to reproduce the analysis presented in: Böschen, I. (2023). Evaluation of the extraction of methodological study characteristics with JATSdecoder. Scientific Reports.
Bribery across nations
Authors: Dorrough Angela , Köbis Nils , Irlenbusch Bernd , Shalvi Shaul , Gloeckner Andreas
Published: January 2023

Bribery, a grand global challenge, often occurs across national jurisdictions. Behavioral research studying bribery to inform anti-corruption interventions, however, has merely examined bribery within single nations. Here, we report online experiments and provide first insights into cross-national bribery. We ran a pilot study (across three nations), and a large, incentivized experiment using a bribery game played across 18 nations (N= 6,472, total number of incentivized decisions = 401,904). Results show that people offer disproportionally more bribes to interaction partners from nations with a high (vs. low) reputation for foreign bribery, measured by macro-level indicators of corruption perceptions. People widely share nation-specific expectations about a nation's bribery acceptance levels. However, these nation-specific expectations negatively correlate with actual bribe acceptance levels, suggesting shared yet inaccurate stereotypes about bribery tendencies. Moreover, the interaction partner’s national background (more than one’s own national background) drives people’s decision to offer or accept a bribe – a finding we label conditional bribery.
A Retrospective Community Perspective: Bridging the Health Disparity Gap with Obesity as the Leading Comorbidity in Disparities in Health Outcomes in the COVID-19 Pandemic
Authors: Peace Odiase , Terry Henry , Banga Amita , Rachakonda Kartik , Garg Amar P , Rachakonda Girish
Published: January 2023

COVID-19 is a viral infection that resulted in a global pandemic. In the United States, COVID-19 caused incommensurate deaths, especially among members of minority groups. Previous literature shows comorbidities such as hypertension (HTN), diabetes mellitus (DM) and obesity (OBS) have been implicated in the severity of COVID-19 cases regardless of racial or ethnic group classification. However, minority populations, particularly people of African descent experienced higher mortality as they carry a disproportionately heavier burden in comorbidities cases. In this study we first confirm current literature on COVID-19 incidence and its correlation with the prevalence of comorbidities in various racial and ethnic populations, using anonymous and aggregated data from the Nashville General Hospital at Meharry, an Institute for the Study of Minority Health. We also evaluated the prevalence of comorbidities in minority patients and computed the correlation between the COVID-19 incidence and a permuted prevalence of comorbidities. A total of 959 patients were reviewed and our study indicates COVID-19 patients classified as Non-Hispanic Blacks (NHB) were approximately 3 times more likely to have an HTN or DM or both HTN and DM diagnosis. The chances double to be approximately six times higher when an OBS diagnosis is included singularly or in conjunction with either HTN or DM or both HTN and DM.
From RGB camera to Hyperspectral imaging: a breakthrough in Neolithic Rock Painting analysis
Authors: Schmitt Bernard , Souidi Zahira , Duquesnoy Frédérique , Donzé Frédéric-Victor
Published: January 2023

Rock paintings undergo physical, chemical, biological and/or anthropic alterations that alter their visibility. Cameras and image enhancement tools (DStretch® plug-in) are commonly used to help identify and record images that have become invisible to the naked eye. HyperSpectral imaging (HSI) which is strongly developing in many research and application fields, is tested in this study to analyze Neolithic rock paintings. We particularly address the question of what kind of additional information can Visible Near InfraRed HSI instruments, coupled to mathematical transformations to reduce the dimensionality of the data, bring for rock paintings, compared to standard RGB cameras. From the analysis of a selection of panels painted on yellow-reddish altered sandstone walls and measured in Saharan shaded shelters we show that HSI can reveal new figures by capitalizing both on its ability to extract the different pigment types with a greater contrast and on the new discriminating information contained in the very near infrared part of the spectrum. Despite their much smaller image format, HSI can provide up to 5-7 contrasted images of the spatial distribution of the different types of pigments in the figures. It thus appears to be a promising non-invasive and efficient methodology to both reveal disappeared paintings and to study image juxtapositions and painted layer superimpositions.
Model-Driven Gap Analysis for the Fulfilment of Quality Standards in Software Development Processes
Authors: Giachetti Giovanni , Vara José Luis de la , Marín Beatriz
Published: January 2023

Nowadays, society is moving to rapid digitalization of almost any aspect of our lives. From healthcare and transport to work or entertainment, we depend on software products that must function properly. The adequate construction of these software products can be evaluated and certified by means of quality standards. However, the adoption of quality standards is a complex and time-consuming task that requires experienced practitioners with advanced knowledge about the standards and development practices. This presents a dichotomy for development companies that are moving to more agile schemes, where the necessary expert knowledge about quality is not easy to get. To overcome these issues, this paper presents a model-driven approach to automate the analysis of software development processes that must be aligned to quality standards. The approach has been implemented in an open-source tool and applied to a case study to automatically generate a gap analysis by reusing expert knowledge related to the ISO 9001 standard. The application has demonstrated that is possible to reduce the effort required to perform the analysis and the improvement of development processes to assure the fulfilment of specific quality standards.
Complete Genomic Analysis of Rabbit Rotavirus G3P[22] in China
Authors: zhao qiaoya , Liu Liping , Huang Tao , Tian Ye , Guo Xiaozhen , Liu Cunxia , Huang Bing , Chen Qiusheng
Published: January 2023

A rabbit rotavirus Z3171 isolate from diarrheic rabbits was identified and sequenced. The genotype constellation of Z3171 was as follows: G3; P[22]; I2; R3; C3; M3; A9; N2; T1; E3; H3,which is different from the constellation observed in previously characterized LRV strains. However, the genome of Z3171 differed substantially from that of the other rabbit rotavirus strains, N5 and Rab1404, in terms of both gene content and gene sequence. Our study shows a reassortment event between human and rabbit rotavirus strains, or there may be undetermined gene clusters circulating in the rabbit population. Further, we report the detection of G3P[22] RVA strain in rabbits from China for the first time.
Distraction and the Use of Modern Communication Devices in the Train Driver’s Cab
Authors: Stoller Nicole , Bruengger Jonas , Wahrstaetter Stefan , Dittrich Melisa , Nisoli Giulio , Hostettler Karin , Fischer Katrin
Published: January 2023

Swiss railway companies provide their train drivers with modern communication devices like cell phones and tablets to perform their tasks. However, the use of these devices can distract the drivers to an extent that is not to be underestimated. Increasing irregularities or unsafe actions, including signals passed at danger, can be attributed at least to a certain extent to the distraction by these mobile and other digital devices in the cab. The goal of this study was to identify appropriate measures to reduce distraction without restricting the scope of action of the train drivers. Based on the results of observations and interviews, we suggested how to address distraction in the driver’s cab from a work psychology and design perspective by considering the individual driver as well as design technology and the organizational processes. In close collaboration with experts of several railway companies we developed a set of 26 preventive and protective measures. Preventive measures aim to avoid distraction, while protective measures aim to reduce the negative consequences of distraction. By carefully selecting and implementing these measures, the railway companies can ultimately support their train drivers to use modern communication devices in the driver’s cab safely and sensibly.
The Comparison of FLOT vs. mDCF Regimens in Neoadjuvant Setting for Locally-advanced Gastric Cancer
Authors: Urun Muslih , Sahin Suleyman , URUN Yonca YILMAZ , Sakin Abdullah
Published: January 2023

Aim:To compare the pathological tumor response and survival of mDCF(modified docetaxel+cisplatin+5-flourosil) vs. FLOT(5-flourosil+oxaliplatin+dosataxel) regimens in the neoadjuvant setting for patients with locally-advanced gastric adenocarcinoma.
Methods: A total of 72 patients, 44 males and 28 females, who were diagnosed with locally-advanced gastric adenocarcinoma and treated with neoadjuvant chemotherapy were included. Postoperative pathological tumor response was compared between the two treatment groups.
Results: There was no significant difference between the treatment regimens in terms of response to treatment, DFS, and OS.
Discussion: Since no significant difference was observed between the regimens in terms of treatment response and survival, we think that cisplatin can be preferred instead of oxaliplatin as a part of neoadjuvant treatment regimen in elderly patients with diabetic neuropathy or high risk of neuropathy.
Ocular Biometric Characteristics in Preoperative Diagnosis of Acute Angle Closure Secondary to Zonular Laxity
Authors: Chen Hailiu , Ye Litong , Cheng Lu , Chen Liming , Lin Jialiu , Li Yangyunhui , Ye Dan , Lu Peng , Huang Jingjing
Published: January 2023

Purpose
To investigate the ocular biometric characteristics of eyes with acute angle closure (AAC) secondary to zonular laxity to further explore the sensitive parameters for preoperative diagnosis.
Methods
This study included 50 patients with AAC secondary to zonular laxity and 54 patients with acute primary angle closure (APAC). Demographic data, ocular examination results and biometric parameters on ultrasound biomicroscopy (UBM) images were compared between the affected and fellow eyes in two groups. Parameters significant in the multiple linear regression model were included in a regression equation and the diagnostic efficiency was evaluated by area under the curve (AUC).
Results
In patients with AAC secondary to zonular laxity, the binocular difference of central anterior chamber depth (ACD), lens vault (LV) in affected eyes and binocular difference of LV were significantly larger than those in patients with APAC respectively and these three parameters were all significant in multiple linear regression analysis (all P < 0.001). The AUC of binocular difference of ACD, LV in affected eyes and binocular difference of LV were 0.972, 0.796, and 0.855, respectively, with the cut-off value of 0.23 mm, 1.28 mm and 0.19 mm, respectively. The regression equation containing these three parameters was: ln (p/(1-p)) = -4.322 + 1.222[LV in affected eyes (mm)] + 3.657[binocular difference of LV (mm)] + 6.542[binocular difference of ACD (mm)], with the accuracy of prediction reaching 94.05%.
Conclusion
Binocular difference of ACD, LV in affected eyes, and binocular difference of LV had high efficiency in diagnosing AAC secondary to zonular laxity.
RNA-targeted therapy corrects neuronal deficits in PACS1 syndrome mice
Authors: Thomas Gary , Villar-Pazos Sabrina , Thomas Laurel , Yang Yunhan , Chen Kun , Lyles Jenea , Deitch Bradley , Ochaba Joseph , Ling Karen , Powers Berit , Gingras Sebastien , Kordasiewicz Holly , Grubisha Melanie , Huang Yanhua
Published: January 2023

Neurodevelopmental disorders (NDDs) are frequently associated with dendritic abnormalities in pyramidal neurons that affect arbor complexity, spine density, and synaptic communication 1,2. The underlying genetic causes are often complex, obscuring the molecular pathways that drive these disorders 3. Next-generation sequencing has identified recurrent de novo missense mutations in a handful of genes associated with NDDs, offering a unique opportunity to decipher the molecular pathways 4. One such gene is PACS1, which encodes the multi-functional trafficking protein PACS1 (or PACS-1); a single recurrent de novo missense mutation, c607C>T (PACS1R203W), causes developmental delay and intellectual disability (ID) 5,6. The processes by which PACS1R203W causes PACS1 syndrome are unknown, and there is no curative treatment. We show that PACS1R203W increases the interaction between PACS1 and the α-tubulin deacetylase HDAC6, elevating enzyme activity and appropriating control of its posttranscriptional regulation. Consequently, PACS1R203W reduces acetylation of α-tubulin and cortactin, causing the Golgi to fragment and enter developing neurites, leading to increased dendrite arborization. The dendrites, however, are beset with diminished spine density and fewer functional synapses, characteristic of ID pathology. Treatment of PACS1 syndrome mice with PACS1- or HDAC6-targeting antisense oligonucleotides restores neuronal structure and synaptic transmission, suggesting PACS1R203W/HDAC6 may be targeted for treating PACS1 syndrome neuropathology.
Clinical and Biochemical Assessment of the Effect of Topical Use of Coenzyme Q10 Versus Topical Corticosteroid in Management of Symptomatic Oral Lichen Planus: Randomized Controlled Clinical Trial
Authors: Abdelsamie Mostafa , Zahran Fat’heya M. , Hussine Amal A. , Shaker Olfat , Al-mahallawi Abdulaziz Mohsen
Published: January 2023

Background: Oral lichen planus (OLP) is a chronic mucocutaneous immunologically mediated condition that has a great adverse effect on oral functions.Corticosteroids are still the first drugs of choice used in the treatment of OLP, however, they have extensive medical side effects. The present study was carried out to assess the clinical therapeutic effect of topical use of coenzyme Q10 (coQ10 or ubiquinol) versus topical corticosteroids in the management of symptomatic OLP and to determine whether the effect, if any, was due to the powerful antioxidant activity of coQ10.
Subjects and Methods: We performed a randomized, double blinded controlled trial at the Faculty of Dentistry, Cairo University, Egypt. The study was conducted on 34 patients suffering from symptomatic OLP. Patients were randomly divided into two groups, intervention group (I), who received topical CoQ10 in the form of mucoadhesive tablets (40% CoQ10) 3 times daily for one month and control group (II), who received topical corticosteroid (kenacort in Orabase: triamcinolone acetonide 0.1% 5 gram adhesive paste – dermapharm), 4 times daily for one month. Patients were evaluated at one-week intervals using the clinical parameters (score) of pain (VAS) and lesion size. Additionally, salivary levels of malondialdehyde (MDA) were assessed in both groups before and after treatment using ELISA. All recorded data wereanalysed using independent t test, ANOVA followed by Bonferroni post hoc test for lesion size and salivary level of MDA data and Mann-Whitney U test and Friedman test for VAS data.
Results: Both groups showed a significant reduction in pain and size of the lesions (p ≤ 0.05) with no statistically significant difference between them (p>0.05) and this clinical improvement was associated with a reduction in the salivary levels of MDA in both groups.
Conclusions: The topical use of CoQ10 mucoadhesive tablets was as effective as the topical use of triamcinolone acetonide, and its clinical effect was associated with reduction in the salivary level of MDA.
Trial registration: The study protocol was registered at www.clinicaltrial.gov (NCT04091698) and registration date: 17/9/2019.
Identification of endoplasmic reticulum stress-related biomarkers in idiopathic pulmonary fibrosis based on machine learning
Authors: Huang Haishan , Wang Zhiqi , Liu Tianyang
Published: January 2023

Background
Endoplasmic reticulum stress (ERS) is critical in the development and progression of idiopathic pulmonary fibrosis (IPF). The aim of this study was to explore ERS-related biomarkers in IPF using a bioinformatics approach and to further investigate their relationship with immune cells. Three IPF datasets (GSE10667, GSE24206 as the training set and GSE53845 as the validation set) were obtained based on the Gene Expression Omnibus (GEO). In the training set, ERS-related differentially expressed genes(DEGs) between IPF and normal tissues were screened and subjected to GO and KEGG enrichment analysis. Key ERS-related DEGs were further screened using Weighted Gene Co-expression Network Analysis (WGCNA) and three machine learning algorithms (Least Absolute Shrinkage and Selection Operator (LASSO), Random Forest (RF), and Support Vector Machine - Recursive Feature Elimination with Local Feature Selection (SVM-RFE)) and validated in a validation set. Then the CIBERSORT method was used to calculate the immune cell infiltration abundance and investigate the relationship between immune cells and key markers.
Results
we obtained 65 ERS-related DEGs from the training set, and 2 key ERS-related DEGs (COMP, GPX8) were screened by WGCNA and machine learning and validated in the validation set. COMP and GPX8 showed high diagnostic value (AUC > 0.8). The results of immune cell infiltration studies showed substantial associations between these two key markers and T-cell CD8, neutrophils, monocytes, macrophage M2 and plasma cells.
Conclusion
COMP and GPX8 are valuable potential biomarkers for IPF and provide a basis for future studies on the early diagnosis and treatment of IPF.