bluuebunny/crossref_metadata_2025 huggingface dataset:
Implications of iron deficiency/anemia on the classification of diabetes using HbA1c
Authors: Attard S M , Herring A H , Wang H , Howard A-G , Thompson A L , Adair L S , Mayer-Davis E J , Gordon-Larsen P
Published: June 2015

Background/Objectives:

Nonglycemic factors like iron deficiency (ID) or anemia may interfere with classification of diabetes and prediabetes using hemoglobin A1c (HbA1c). However, few population-based studies of diabetes in areas with endemic ID/anemia have been conducted. We aimed to determine how mutually exclusive categories of ID alone, anemia alone and iron-deficiency anemia (IDA) were each associated with prediabetes and diabetes prevalence using fasting blood glucose (FBG) versus HbA1c in a population-based study of adults with endemic ID/anemia.

Subjects/Methods:

We used data from the China Health and Nutrition Survey, a longitudinal, population-based study across 228 communities within nine provinces of China. This analysis included 7308 adults seen in the 2009 survey aged 18–75 years. We used descriptive and covariate-adjusted models to examine relative risk of prediabetes and diabetes using FBG alone, HbA1c alone, HbA1c and FBG, or neither (normoglycemia) by anemia alone, ID alone, IDA or normal iron/hemoglobin.

Results:

Approximately 65% of individuals with diabetes in our sample were concordantly classified with diabetes using both FBG and HbA1c, while 35% had a discordant diabetes classification: they were classified using either FBG or HbA1c, but not both. Fewer participants with ID alone versus normal iron/hemoglobin were classified with diabetes using HbA1c only. From covariate-adjusted, multinomial regression analyses, the adjusted prevalence of prediabetes using HbA1c only was 22% for men with anemia alone, but 13% for men with normal iron/hemoglobin. In contrast, the predicted prevalence of prediabetes using HbA1c only was 8% for women with ID alone, compared with 13% for women with normal iron/hemoglobin.

Conclusions:

These findings suggest potential misclassification of diabetes using HbA1c in areas of endemic ID/anemia. Estimating diabetes prevalence using HbA1c may result in under-diagnosis in women with ID and over-diagnosis in men with anemia.
Comparative, transcriptome analysis of self-organizing optic tissues
Authors: Andrabi Munazah , Kuraku Shigehiro , Takata Nozomu , Sasai Yoshiki , Love Nick R.
Published: June 2015

Embryonic stem (ES) cells have a remarkable capacity to self-organize complex, multi-layered optic cups in vitro via a culture technique called SFEBq. During both SFEBq and in vivo optic cup development, Rax (Rx) expressing neural retina epithelial (NRE) tissues utilize Fgf and Wnt/β-catenin signalling pathways to differentiate into neural retina (NR) and retinal-pigmented epithelial (RPE) tissues, respectively. How these signaling pathways affect gene expression during optic tissue formation has remained largely unknown, especially at the transcriptome scale. Here, we address this question using RNA-Seq. We generated Rx+ optic tissue using SFEBq, exposed these tissues to either Fgf or Wnt/β-catenin stimulation, and assayed their gene expression across multiple time points using RNA-Seq. This comparative dataset will help elucidate how Fgf and Wnt/β-catenin signaling affect gene expression during optic tissue differentiation and will help inform future efforts to optimize in vitro optic tissue culture technology.
Exposure of clownfish larvae to suspended sediment levels found on the Great Barrier Reef: Impacts on gill structure and microbiome
Authors: Hess Sybille , Wenger Amelia S. , Ainsworth Tracy D. , Rummer Jodie L.
Published: June 2015

Worldwide, increasing coastal development has played a major role in shaping coral reef species assemblages, but the mechanisms underpinning distribution patterns remain poorly understood. Recent research demonstrated delayed development in larval fishes exposed to suspended sediment, highlighting the need to further understand the interaction between suspended sediment as a stressor and energetically costly activities such as growth and development that are essential to support biological fitness. We examined the gill morphology and the gill microbiome in clownfish larvae (Amphiprion percula) exposed to suspended sediment concentrations (using Australian bentonite) commonly found on the inshore Great Barrier Reef. The gills of larvae exposed to 45 mg L−1 of suspended sediment had excessive mucous discharge and growth of protective cell layers, resulting in a 56% thicker gill epithelium compared to fish from the control group. Further, we found a shift from ‘healthy’ to pathogenic bacterial communities on the gills, which could increase the disease susceptibility of larvae. The impact of suspended sediments on larval gills may represent an underlying mechanism behind the distribution patterns of fish assemblages. Our findings underscore the necessity for future coastal development to consider adverse effects of suspended sediments on fish recruitment and consequently fish populations and ecosystem health.
Antitumor and Adjuvant Activity of λ-carrageenan by Stimulating Immune Response in Cancer Immunotherapy
Authors: Luo Min , Shao Bin , Nie Wen , Wei Xia-Wei , Li Yu-Li , Wang Bi-Lan , He Zhi-Yao , Liang Xiao , Ye Ting-Hong , Wei Yu-Quan
Published: June 2015

λ-Carrageenan is a seaweed polysaccharide which has been generally used as proinflammatory agent in the basic research, however, how the immunomodulating activity of λ-carrageenan affects tumor microenvironment remains unknown. In this study, we found that intratumoral injection of λ-carrageenan could inhibit tumor growth in B16-F10 and 4T1 bearing mice and enhance tumor immune response by increasing the number of tumor-infiltrating M1 macrophages, DCs and more activated CD4+CD8+ T lymphocytes in spleen. In addition, λ-carrageenan could enhance the secretion of IL17A in spleen and significantly increase the level of TNF-α in tumor, most of which was secreted by infiltrating macrophages. Moreover, λ-carrageenan exhibited an efficient adjuvant effect in OVA-based preventative and therapeutic vaccine for cancer treatment, which significantly enhanced the production of anti-OVA antibody. The toxicity analysis suggested that λ-carrageenan was with a good safety profile. Thus, λ-carrageenan might be used both as a potent antitumor agent and an efficient adjuvant in cancer immunotherapy.
SNSMIL, a real-time single molecule identification and localization algorithm for super-resolution fluorescence microscopy
Authors: Tang Yunqing , Dai Luru , Zhang Xiaoming , Li Junbai , Hendriks Johnny , Fan Xiaoming , Gruteser Nadine , Meisenberg Annika , Baumann Arnd , Katranidis Alexandros , Gensch Thomas
Published: June 2015

Single molecule localization based super-resolution fluorescence microscopy offers significantly higher spatial resolution than predicted by Abbe’s resolution limit for far field optical microscopy. Such super-resolution images are reconstructed from wide-field or total internal reflection single molecule fluorescence recordings. Discrimination between emission of single fluorescent molecules and background noise fluctuations remains a great challenge in current data analysis. Here we present a real-time and robust single molecule identification and localization algorithm, SNSMIL (Shot Noise based Single Molecule Identification and Localization). This algorithm is based on the intrinsic nature of noise, i.e., its Poisson or shot noise characteristics and a new identification criterion, QSNSMIL, is defined. SNSMIL improves the identification accuracy of single fluorescent molecules in experimental or simulated datasets with high and inhomogeneous background. The implementation of SNSMIL relies on a graphics processing unit (GPU), making real-time analysis feasible as shown for real experimental and simulated datasets.
Fabrication of nanoscale Ga balls via a Coulomb explosion of microscale silica-covered Ga balls by TEM electron-beam irradiation
Authors: Chen Ying , Huang Yanli , Liu Nishuang , Su Jun , Li Luying , Gao Yihua
Published: June 2015

Nanoscale Ga particles down to 5 nm were fabricated by an explosion via an in situ electron-beam irradiation on microscale silica-covered Ga balls in a transmission electron microscope. The explosion is confirmed to be a Coulomb explosion because it occurs on the surface rather than in the whole body of the insulating silica-covered Ga micro–balls and on the pure Ga nano-balls on the edge of carbon film. The ejected particles in the explosion increase their sizes with increasing irradiation time until the stop of the explosion, but decrease their sizes with increasing distance from the original ball. The Coulomb explosion suggests a novel method to fabricate nanoscale metal particles with low melting point.
Accumulation of nanoparticles in “jellyfish” mucus: a bio-inspired route to decontamination of nano-waste
Authors: Patwa Amit , Thiéry Alain , Lombard Fabien , Lilley Martin K.S. , Boisset Claire , Bramard Jean-François , Bottero Jean-Yves , Barthélémy Philippe
Published: June 2015

The economic and societal impacts of nano-materials are enormous. However, releasing such materials in the environment could be detrimental to human health and the ecological biosphere. Here we demonstrate that gold and quantum dots nanoparticles bio-accumulate into mucus materials coming from natural species such as jellyfish. One strategy that emerges from this finding would be to take advantage of these trapping properties to remove nanoparticles from contaminated water.
Surface chemistry but not aspect ratio mediates the biological toxicity of gold nanorods in vitro and in vivo
Authors: Wan Jiali , Wang Jia-Hong , Liu Ting , Xie Zhixiong , Yu Xue-Feng , Li Wenhua
Published: June 2015

Gold nanorods are a promising nanoscale material in clinical diagnosis and treatment. The physicochemical properties of GNRs, including size, shape and surface features, are crucial factors affecting their cytotoxicity. In this study, we investigated the effects of different aspect ratios and surface modifications on the cytotoxicity and cellular uptake of GNRs in cultured cells and in mice. The results indicated that the surface chemistry but not the aspect ratio of GNRs mediates their biological toxicity. CTAB-GNRs with various aspect ratios had similar abilities to induce cell apoptosis and autophagy by damaging mitochondria and activating intracellular reactive oxygen species (ROS). However, GNRs coated with CTAB/PSS, CTAB/PAH, CTAB/PSS/PAH or CTAB/PAH/PSS displayed low toxicity and did not induce cell death. CTAB/PAH-coated GNRs caused minimally abnormal cell morphology compared with CTAB/PSS and CTAB/PSS/PAH coated GNRs. Moreover, the intravenous injection of CTAB/PAH GNRs enabled the GNRs to reach tumor tissues through blood circulation in animals and remained stable, with a longer half-life compared to the other GNRs. Therefore, our results demonstrated that further coating can prevent cytotoxicity and cell death upon CTAB-coated GNR administration, similar to changing the GNR aspect ratio and CTAB/PAH coated GNRs show superior biological properties with better biocompatibility and minimal cytotoxicity.
GONAD: Genome-editing via Oviductal Nucleic Acids Delivery system: a novel microinjection independent genome engineering method in mice
Authors: Takahashi Gou , Gurumurthy Channabasavaiah B , Wada Kenta , Miura Hiromi , Sato Masahiro , Ohtsuka Masato
Published: June 2015

Microinjection is considered the gold standard technique for delivery of nucleic acids (NAs; transgenes or genome editing tools such as CRISPR/Cas9 systems) into embryos, for creating genetically modified organisms. It requires sophisticated equipment as wel as well-trained and highly skilled personnel to perform the micro-injection technique. Here, we describe a novel and simple microinjection-independent technique, called Genome-editing via Oviductal Nucleic Acids Delivery (GONAD). Using GONAD, we show that NAs (e.g., eGFP mRNA or Cas9 mRNA/sgRNAs) can be effectively delivered to pre-implantation embryos within the intact mouse oviduct by a simple electroporation method and result in the desired genetic modification in the embryos. Thus GONAD can bypass many complex steps in transgenic technology such as isolation of zygotes, microinjection of NAs into them and their subsequent transfer to pseudo-pregnant animals. Furthermore, this method can potentially be used for genome editing in species other than mice.
Probing Majorana bound states via counting statistics of a single electron transistor
Authors: Li Zeng-Zhao , Lam Chi-Hang , You J. Q.
Published: June 2015

We propose an approach for probing Majorana bound states (MBSs) in a nanowire via counting statistics of a nearby charge detector in the form of a single-electron transistor (SET). We consider the impacts on the counting statistics by both the local coupling between the detector and an adjacent MBS at one end of a nanowire and the nonlocal coupling to the MBS at the other end. We show that the Fano factor and the skewness of the SET current are minimized for a symmetric SET configuration in the absence of the MBSs or when coupled to a fermionic state. However, the minimum points of operation are shifted appreciably in the presence of the MBSs to asymmetric SET configurations with a higher tunnel rate at the drain than at the source. This feature persists even when varying the nonlocal coupling and the pairing energy between the two MBSs. We expect that these MBS-induced shifts can be measured experimentally with available technologies and can serve as important signatures of the MBSs.
Age and CHADS2 Score Predict the Effectiveness of Renin-Angiotensin System Blockers on Primary Prevention of Atrial Fibrillation
Authors: Hung Chen-Ying , Hsieh Yu-Cheng , Li Cheng-Hung , Huang Jin-Long , Lin Ching-Heng , Wu Tsu-Juey
Published: June 2015

Renin-angiotensin system (RAS) blockers have potential protective effects against atrial fibrillation (AF). The purpose of this study was to determine if patient characteristics and underlying co-morbidities could predict the efficacy of RAS blockers in AF prevention. Patients aged ≥ 45 years with hypertension were identified from the Taiwan National Health Insurance Research Database. After propensity-score matching, a total of 22,324 patients were included in this study. Risk of new-onset AF in RAS blockers users and non-users was estimated. During up to 10 years of follow-up, 1,475 patients experienced new-onset AF. Overall, RAS blockers reduced the risk of AF by 36% (adjusted HR 0.64; 95% CI 0.58 to 0.71; p < 0.001). Subgroup analysis showed that RAS blockers use was beneficial for AF prevention in patients aged ≥ 55 years or with a CHADS2 score of 1, 2, or 3. The therapy provided no obvious beneficial effect for AF prevention in those aged less than 55 years or with a CHADS2 score ≥ 4. In conclusion, RAS blockers reduced the risk of new-onset AF in patients aged ≥ 55 years or with a CHADS2 score of 1, 2, or 3, but not in patients aged less than 55 years or with a CHADS2 score ≥ 4.
Peptide-modified Substrate for Modulating Gland Tissue Growth and Morphology In Vitro
Authors: Taketa Hiroaki , Sathi Gulsan Ara , Farahat Mahmoud , Rahman Kazi Anisur , Sakai Takayoshi , Hirano Yoshiaki , Kuboki Takuo , Torii Yasuhiro , Matsumoto Takuya
Published: June 2015

In vitro fabricated biological tissue would be a valuable tool to screen newly synthesized drugs or understand the tissue development process. Several studies have attempted to fabricate biological tissue in vitro. However, controlling the growth and morphology of the fabricated tissue remains a challenge. Therefore, new techniques are required to modulate tissue growth. RGD (arginine-glycine-aspartic acid), which is an integrin-binding domain of fibronectin, has been found to enhance cell adhesion and survival; it has been used to modify substrates for in vitro cell culture studies or used as tissue engineering scaffolds. In addition, this study shows novel functions of the RGD peptide, which enhances tissue growth and modulates tissue morphology in vitro. When an isolated submandibular gland (SMG) was cultured on an RGD-modified alginate hydrogel sheet, SMG growth including bud expansion and cleft formation was dramatically enhanced. Furthermore, we prepared small RGD-modified alginate beads and placed them on the growing SMG tissue. These RGD-modified beads successfully induced cleft formation at the bead position, guiding the desired SMG morphology. Thus, this RGD-modified material might be a promising tool to modulate tissue growth and morphology in vitro for biological tissue fabrication.
Improving prediction of secondary structure, local backbone angles and solvent accessible surface area of proteins by iterative deep learning
Authors: Heffernan Rhys , Paliwal Kuldip , Lyons James , Dehzangi Abdollah , Sharma Alok , Wang Jihua , Sattar Abdul , Yang Yuedong , Zhou Yaoqi
Published: June 2015

Direct prediction of protein structure from sequence is a challenging problem. An effective approach is to break it up into independent sub-problems. These sub-problems such as prediction of protein secondary structure can then be solved independently. In a previous study, we found that an iterative use of predicted secondary structure and backbone torsion angles can further improve secondary structure and torsion angle prediction. In this study, we expand the iterative features to include solvent accessible surface area and backbone angles and dihedrals based on Cα atoms. By using a deep learning neural network in three iterations, we achieved 82% accuracy for secondary structure prediction, 0.76 for the correlation coefficient between predicted and actual solvent accessible surface area, 19° and 30° for mean absolute errors of backbone φ and ψ angles, respectively and 8° and 32° for mean absolute errors of Cα-based θ and τ angles, respectively, for an independent test dataset of 1199 proteins. The accuracy of the method is slightly lower for 72 CASP 11 targets but much higher than those of model structures from current state-of-the-art techniques. This suggests the potentially beneficial use of these predicted properties for model assessment and ranking.
Fill factor in organic solar cells can exceed the Shockley-Queisser limit
Authors: Trukhanov Vasily A. , Bruevich Vladimir V. , Paraschuk Dmitry Yu.
Published: June 2015

The ultimate efficiency of organic solar cells (OSC) is under active debate. The solar cell efficiency is calculated from the current-voltage characteristic as a product of the open-circuit voltage (VOC), short-circuit current (JSC) and the fill factor (FF). While the factors limiting VOC and JSC for OSC were extensively studied, the ultimate FF for OSC is scarcely explored. Using numerical drift-diffusion modeling, we have found that the FF in OSC can exceed the Shockley-Queisser limit (SQL) established for inorganic p–n junction solar cells. Comparing charge generation and recombination in organic donor-acceptor bilayer heterojunction and inorganic p–n junction, we show that such distinctive properties of OSC as interface charge generation and heterojunction facilitate high FF, but the necessary condition for FF exceeding the SQL in OSC is field-dependence of charge recombination at the donor-acceptor interface. These findings can serve as a guideline for further improvement of OSC.
Atom–Photon Coupling from Nitrogen-vacancy Centres Embedded in Tellurite Microspheres
Authors: Ruan Yinlan , Gibson Brant C. , Lau Desmond W. M. , Greentree Andrew D. , Ji Hong , Ebendorff-Heidepriem Heike , Johnson Brett C. , Ohshima Takeshi , Monro Tanya M.
Published: June 2015

We have developed a technique for creating high quality tellurite microspheres with embedded nanodiamonds (NDs) containing nitrogen-vacancy (NV) centres. This hybrid method allows fluorescence of the NVs in the NDs to be directly, rather than evanescently, coupled to the whispering gallery modes of the tellurite microspheres at room temperature. As a demonstration of its sensing potential, shifting of the resonance peaks is also demonstrated by coating a sphere surface with a liquid layer. This new approach is a robust way of creating cavities for use in quantum and sensing applications.
Breathable and Stretchable Temperature Sensors Inspired by Skin
Authors: Chen Ying , Lu Bingwei , Chen Yihao , Feng Xue
Published: June 2015

Flexible electronics attached to skin for healthcare, such as epidermal electronics, has to struggle with biocompatibility and adapt to specified environment of skin with respect to breath and perspiration. Here, we report a strategy for biocompatible flexible temperature sensors, inspired by skin, possessing the excellent permeability of air and high quality of water-proof by using semipermeable film with porous structures as substrate. We attach such temperature sensors to underarm and forearm to measure the axillary temperature and body surface temperature respectively. The volunteer wears such sensors for 24 hours with two times of shower and the in vitro test shows no sign of maceration or stimulation to the skin. Especially, precise temperature changes on skin surface caused by flowing air and water dropping are also measured to validate the accuracy and dynamical response. The results show that the biocompatible temperature sensor is soft and breathable on the human skin and has the excellent accuracy compared to mercury thermometer. This demonstrates the possibility and feasibility of fully using the sensors in long term body temperature sensing for medical use as well as sensing function of artificial skin for robots or prosthesis.
Integrative miRNA and Gene Expression Profiling Analysis of Human Quiescent Hepatic Stellate Cells
Authors: Coll Mar , Taghdouini Adil El , Perea Luis , Mannaerts Inge , Vila-Casadesús Maria , Blaya Delia , Rodrigo-Torres Daniel , Affò Silvia , Morales-Ibanez Oriol , Graupera Isabel , Lozano Juan José , Najimi Mustapha , Sokal Etienne , Lambrecht Joeri , Ginès Pere , van Grunsven Leo A. , Sancho-Bru Pau
Published: June 2015

Unveiling the regulatory pathways maintaining hepatic stellate cells (HSC) in a quiescent (q) phenotype is essential to develop new therapeutic strategies to treat fibrogenic diseases. To uncover the miRNA-mRNA regulatory interactions in qHSCs, HSCs were FACS-sorted from healthy livers and activated HSCs (aHSCs) were generated in vitro. MiRNA Taqman array analysis showed HSCs expressed a low number of miRNAs (n = 259), from which 47 were down-regulated and 212 up-regulated upon activation. Computational integration of miRNA and gene expression profiles revealed that 66% of qHSC-associated miRNAs correlated with more than 6 altered target mRNAs (17,28 ± 10,7 targets/miRNA) whereas aHSC-associated miRNAs had an average of 1,49 targeted genes. Interestingly, interaction networks generated by miRNA-targeted genes in qHSCs were associated with key HSC activation processes. Next, selected miRNAs were validated in healthy and cirrhotic human livers and miR-192 was chosen for functional analysis. Down-regulation of miR-192 in HSCs was found to be an early event during fibrosis progression in mouse models of liver injury. Moreover, mimic assays for miR-192 in HSCs revealed its role in HSC activation, proliferation and migration. Together, these results uncover the importance of miRNAs in the maintenance of the qHSC phenotype and form the basis for understanding the regulatory networks in HSCs.
Towards deep-UV surface-enhanced resonance Raman spectroscopy of explosives: ultrasensitive, real-time and reproducible detection of TNT
Authors: Jha Shankar K. , Ekinci Yasin , Agio Mario , Löffler Jörg F.
Published: June 2015

We report ultrasensitive and label-free detection of 2,4,6-trinitrotoluene (TNT) deposited by drop coating using deep-ultraviolet surface-enhanced resonance Raman scattering (DUV-SERRS).
Fluorescence polarization immunoassays for carbamazepine – comparison of tracers and formats
Authors: Oberleitner Lidia , Eremin Sergei A. , Lehmann Andreas , Garbe Leif-Alexander , Schneider Rudolf J.
Published: June 2015

Fast fluorescence polarization immunoassays for the detection of carbamazepine in surface water were developed.
An immunoblot-based optical biosensor for screening of osteoarthritis using a smartphone-embedded illuminometer
Authors: Park Yoo Min , Han Yong Duk , Kim Ka Ram , Zhang Cunqiang , Yoon Hyun C.
Published: June 2015

We report a new smartphone-based immunosensing system that integrates an immunoblotting assay and a built-in illumination sensor to assay an osteoarthritis marker.
Determination of ketoacids in drinking water by DNPH derivatization and LC-ESI-MS/MS
Authors: Mao Yu-qin , Wang Xiao-mao , Tang Shun , Yang Hong-wei , Xie Yuefeng F.
Published: June 2015

A quantitative method for determination of ketoacids, including glyoxylic acid, pyruvic acid and ketomalonic acid, in ozonated drinking water was developed by using 2,4-dinitrophenylhydrazine (DNPH) derivatization combined with liquid chromatography-electrospray mass spectrometry analysis.
An acetylcholinesterase inhibition biosensor based on a reduced graphene oxide/silver nanocluster/chitosan nanocomposite for detection of organophosphorus pesticides
Authors: Zhang Yanli , Liu Hongjun , Yang Zhongming , Ji Shunlin , Wang Junfang , Pang Pengfei , Feng Lili , Wang Hongbin , Wu Zhan , Yang Wenrong
Published: June 2015

A sensitive electrochemical acetylcholinesterase biosensor based on a reduced graphene oxide and silver nanocluster modified glassy carbon electrode was developed.
Selective photosensitization through an AND logic response: optimization of the pH and glutathione response of activatable photosensitizers
Authors: Erbas-Cakmak Sundus , Cakmak Fatma Pir , Topel Seda Demirel , Uyar Taha Bilal , Akkaya Engin U.
Published: June 2015

A molecular AND logic gate, which is an activatable photosensitizer, requires above-threshold values of acidity (pH) and GSH for full activity.
Unexpected optical limiting properties from MoS2 nanosheets modified by a semiconductive polymer
Authors: Zhao Min , Chang Meng-Jie , Wang Qiang , Zhu Zhen-Tong , Zhai Xin-Ping , Zirak Mohammad , Moshfegh Alireza Z. , Song Ying-Lin , Zhang Hao-Li
Published: June 2015

We have developed a facile method for exfoliation of MoS2 with the assistance of P3HT to synthetize a P3HT–MoS2 nanohybrid which shows unexpected optical limiting properties compared with the individual compartments.
Aggregates of the pentacenequinone derivative as reactors for the preparation of Ag@Cu2O core–shell NPs: an active photocatalyst for Suzuki and Suzuki type coupling reactions
Authors: Sharma Kamaldeep , Kumar Manoj , Bhalla Vandana
Published: June 2015

Aggregates of the pentacenequinone derivative stabilized Ag@Cu2O core–shell nanoparticles (NPs) enabled efficient visible light harvesting to catalyse the palladium free Suzuki–Miyaura and Suzuki type cross coupling reactions at room temperature.
A “keto–enol tautomerization”-based response mechanism: a novel approach to stimuli-responsive supramolecular gel
Authors: Lin Qi , Lu Tao-Tao , Lou Jin-Chao , Wu Gui-Yuan , Wei Tai-Bao , Zhang You-Ming
Published: June 2015

By “keto–enol tautomerization”, gelator G3 can be self-assembled into a stable organogel (OG3) accompanied by strong aggregation induced emission (AIE). OG3 could dual-channel sense S2− with specific selectivity via reversible sol–gel transition and fluorescent changes.
Chiral N,N′-dioxide–FeCl3 complex-catalyzed asymmetric intramolecular Cannizzaro reaction
Authors: Wu Wangbin , Liu Xiaohua , Zhang Yuheng , Ji Jie , Huang Tianyu , Lin Lili , Feng Xiaoming
Published: June 2015

An environmentally benign catalyst, the N,N′-dioxide–FeCl3 complex, has been developed for the asymmetric intramolecular Cannizzaro reaction with high yields and enantioselectivities.
Significant stabilization of palladium by gold in the bimetallic nanocatalyst leading to an enhanced activity in the hydrodechlorination of aryl chlorides
Authors: Karanjit Sangita , Jinasan Atchaleeya , Samsook Ekasith , Dhital Raghu N. , Motomiya Kenichi , Sato Yoshinori , Tohji Kazuyuki , Sakurai Hidehiro
Published: June 2015

The stabilization of Pd by Au in Au/Pd bimetallic nanoclusters enhanced the reactivity of Pd and changed the reaction mechanism.
Asymmetric synthesis of optically active methyl-2-benzamido-methyl-3-hydroxy-butyrate by robust short-chain alcohol dehydrogenases from Burkholderia gladioli
Authors: Chen Xiang , Liu Zhi-Qiang , Huang Jian-Feng , Lin Chao-Ping , Zheng Yu-Guo
Published: June 2015

Specific short-chain alcohol dehydrogenases were discovered and used in the dynamic kinetic asymmetric transformation of methyl 2-benzamido-methyl-3-oxobutanoate with excellent stereo-selectivity.
A Cu4S model for the nitrous oxide reductase active sites supported only by nitrogen ligands
Authors: Johnson Brittany J. , Antholine William E. , Lindeman Sergey V. , Mankad Neal P.
Published: June 2015

A tetracopper sulphide complex supported only by nitrogen ligands models the catalytic sites of nitrous oxide reductase.
Study of temperature and ligand flexibility effects on coordination polymer formation from cyclobutanetetracarboxylic acid
Authors: Bello Lizaira , Quintero Marilyn , Mora Asiloé J. , González Teresa , Escalona Ana , Añez Rafael , Ávila Edward E. , Briceño Alexander
Published: June 2015

Three novel coordination polymers (CPs) from rctt-H4Cbtc and 4,4’-bpe with Zn and Ni metal nodes have been synthesized. The CP derivates of Zn are an unusual example for the preparation of metastable phases involving temperature dependent and concomitant transformation.
Zinc and cadmium metal-directed coordination polymers: in situ flexible tetrazole ligand synthesis, structures, and properties
Authors: Dong Ruo Ting , Ma Zhao Ying , Chen Li Xin , Huang Lan Fen , Li Qian Hong , Hu Ming Yuan , Shen Mo Yuan , Li Chu Wen , Deng Hong
Published: June 2015

Seven zinc and cadmium coordination frameworks were obtained through in situ tetrazole synthesis. By varying the hydrothermal conditions the unprecedented generation of tetrazole ligands were achieved.
Novel high-temperature ferroelectric single crystals 0.38Bi(Mg1/2Ti1/2)O3–0.62PbTiO3 with good and temperature-stable piezoelectric properties
Authors: Liu Jinfeng , Chen Xiaxia , Xu Guisheng , Yang Danfeng , Tian Yanfeng , Zhu Xiu
Published: June 2015

Novel 0.38BMT–0.62PbT single crystals with high Tc, as well as good and temperature-stable piezoelectric properties have been grown by a flux method.
Modelling the mobility of positive ion clusters in normal liquid helium over large pressure ranges
Authors: Aitken Frédéric , Bonifaci Nelly , Mendoza-Luna Luis Guillermo , von Haeften Klaus
Published: June 2015

Positively charged helium clusters, also called ‘snowballs’, have been investigated within normal liquid helium.
Tuning interionic interaction for highly selective in vivo analysis
Authors: Yu Ping , He Xiulan , Mao Lanqun
Published: June 2015

The interionic interaction demonstrated here refers to the interaction between ions and their counterparts, which is not only composed of electrostatic attraction between oppositely charged species but also other kinds of weak interactions. This review focuses on the recent progress in the tuning of interionic interaction to improve the selectivity of biosensors for in vivo analysis.
Flow chemistry as a versatile tool for the synthesis of triazoles
Authors: Ötvös Sándor B. , Fülöp Ferenc
Published: June 2015

This review surveys the continuous-flow strategies for the synthesis of triazoles by means of copper-catalyzed and catalyst-free cycloadditions between azides and various dipolarophiles.
Noncovalent interactions determine the conformation of aurophilic complexes with 2-mercapto-4-methyl-5-thiazoleacetic acid ligands
Authors: Hapka Michał , Dranka Maciej , Orłowska Katarzyna , Chałasiński Grzegorz , Szczęśniak Małgorzata M. , Zachara Janusz
Published: June 2015

The synthesis of three new gold(i) salts is reported. The intermolecular interactions stabilizing the aurophilic dimers are examined by several first principles interpretative techniques.
Dipyrrolylquinoxaline difluoroborates with intense red solid-state fluorescence
Authors: Yu Changjiang , Hao Erhong , Li Tingting , Wang Jun , Sheng Wanle , Wei Yun , Mu Xiaolong , Jiao Lijuan
Published: June 2015

Dipyrrolylquinoxalines and their BF2 complexes were synthesized and characterized by their X-ray structural analysis, optical and electrochemical properties. These dyes exhibit strong broad absorption in the visible region and intensely tunable solid-state fluorescence.
The osmotic membrane bioreactor: a critical review
Authors: Holloway Ryan W. , Achilli Andrea , Cath Tzahi Y.
Published: June 2015

The osmotic membrane bioreactor (OMBR) is a hybrid biological-physical treatment process for wastewater treatment and water reuse.
Impact of bread making on fructan chain integrity and effect of fructan enriched breads on breath hydrogen, satiety, energy intake, PYY and ghrelin
Authors: Morris C. , Lynn A. , Neveux C. , Hall A. C. , Morris G. A.
Published: June 2015

Degree of polymerisation and gut fermentation of FOS and inulin in bread.
Highly efficient reduction of bromate to bromide over mono and bimetallic ZSM5 catalysts
Authors: Freitas C. M. A. S. , Soares O. S. G. P. , Órfão J. J. M. , Fonseca A. M. , Pereira M. F. R. , Neves I. C.
Published: June 2015

Reduction of bromate to bromide over mono and bimetallic ZSM5 catalysts was efficiently achieved and PdCu–ZSM5 is the best catalyst.
Effective deoxygenation of fatty acids over Ni(OAc)2 in the absence of H2 and solvent
Authors: Li Wenjing , Gao Yongjun , Yao Siyu , Ma Ding , Yan Ning
Published: June 2015

Different metal acetate salts were systematically examined for the catalytic deoxygenation of stearic acid in the absence of H2 and solvent for the first time.
Research highlights: surface-based microfluidic control
Authors: Adeyiga Oladunni , Kahkeshani Soroush , Paiè Petra , Di Carlo Dino
Published: June 2015

One microstructure to repel them all – Capillarity-guided micropatterning – Droplets chasing droplets.
Correction: AACVD of Cu2−xS, In2S3 and CuInS2 thin films from [Cu(iBu2PS2)(PPh3)2] and [In(iBu2PS2)3] as single source precursors
Authors: Malik Sajid N. , Malik Abdul Qadeer , Mehmood Rana Farhat , Murtaza Ghulam , Alghamdi Yousef G. , Malik Mohammad Azad
Published: June 2015

Correction for ‘AACVD of Cu2−xS, In2S3 and CuInS2 thin films from [Cu(iBu2PS2)(PPh3)2] and [In(iBu2PS2)3] as single source precursors’ by Sajid N. Malik et al., New J. Chem., 2015, 39, 4047–4054.
A new route for the synthesis of highly substituted 4-aminoquinoline drug like molecules via aza hetero–Diels–Alder reaction
Authors: Vidyacharan Shinde , Sagar A. , Sharada Duddu S.
Published: June 2015

A new route has been developed for the synthesis of 4-aminoquinoline drug like moleculesviaaza hetero–Diels–Alder reaction starting from 2H-indazole as a diene for the first time.
Asymmetric aza-Henry reaction to provide oxindoles with quaternary carbon stereocenter catalyzed by a metal-templated chiral Brønsted base
Authors: Hu Ying , Zhou Zijun , Gong Lei , Meggers Eric
Published: June 2015

An inert octahedral chiral-at-metal iridium(iii) complex serves as a highly effective chiral Brønsted base catalyst for implementing a quaternary carbon stereocenter.
Thermal runaway of commercial 18650 Li-ion batteries with LFP and NCA cathodes – impact of state of charge and overcharge
Authors: Golubkov Andrey W. , Scheikl Sebastian , Planteu René , Voitic Gernot , Wiltsche Helmar , Stangl Christoph , Fauler Gisela , Thaler Alexander , Hacker Viktor
Published: June 2015

Destructive thermal ramp experiments with commercial Li-ion batteries at different state of charge were made. Produced gases were quantified and a causing chemical reaction system is proposed.
Phosphorous-modified ordered mesoporous carbon for catalytic dehydrogenation of propane to propylene
Authors: Li Lina , Zhu Wenliang , Liu Yong , Shi Lei , Liu Hongchao , Ni Youming , Liu Shiping , Zhou Hui , Liu Zhongmin
Published: June 2015

In the DH of propane, the PO groups were believed to be electron donors for CO active centers, or independent active centers.
Eco-friendly, catalyst-free synthesis of highly pure carbon spheres using vegetable oils as a renewable source and their application as a template for ZnO and MgO hollow spheres
Authors: Sawant Sandesh Y. , Senthilkumar S. , Somani Rajesh S. , Cho Moo Hwan , Bajaj Hari C.
Published: June 2015

Herein we report the eco-friendly and catalyst-free single step synthesis of solid carbon spheres, 1–10 μm in diameter, using vegetable oils derived from different bio-resources as the carbon source.
Molecular design of new organic sensitizers based on thieno[1,4]benzothiazine for dye-sensitized solar cells
Authors: Liu Hu , Liao Xingrong , Li Xiaoyu , Wu Di , Guo Qiang , Wu Jie , Qian Shengyou , Lan Jingbo , Wang Ruilin , You Jingsong
Published: June 2015

A novel thieno[1,4]benzothiazine donor has been developed for the first time to construct metal-free organic sensitizers, which exhibit more dramatically red-shifted absorptions than phenothiazine-based dyes.
Outstanding electromagnetic interference shielding of silver nanowires: comparison with carbon nanotubes
Authors: Arjmand Mohammad , Moud Aref Abbasi , Li Yan , Sundararaj Uttandaraman
Published: June 2015

Synthesized silver nanowire/polystyrene nanocomposites showed superior electrical properties to commercial carbon nanotube/polystyrene nanocomposites at high filler loadings. This was ascribed to the higher metallic nature of silver nanowires.
A novel nanocomposite for bone tissue engineering based on chitosan–silk sericin/hydroxyapatite: biomimetic synthesis and its cytocompatibility
Authors: Chen Li , Hu Jingxiao , Ran Jiabing , Shen Xinyu , Tong Hua
Published: June 2015

Scheme of the formation mechanism of CS–SS/HA-s and CS–SS/HA-g nanocomposites.
Study of the effect of a novel high-performance gel polymer electrolyte based on thermoplastic polyurethane/poly(vinylidene fluoride)/polystyrene and formed using an electrospinning technique
Authors: Tang Xiaoli , Cao Qi , Wang Xianyou , Peng Xiuxiang , Zeng Juan
Published: June 2015

Nanofibrous membranes based on poly(vinylidene fluoride) doped with thermoplastic polyurethane and polystyrene are prepared using an electrospinning technique and composite gel polymer electrolytes are obtained after activation in liquid electrolyte.
Preparation of porous 3D Ce-doped ZnO microflowers with enhanced photocatalytic performance
Authors: Liang Yimai , Guo Na , Li Linlin , Li Ruiqing , Ji Guijuan , Gan Shucai
Published: June 2015

Porous 3D Ce-doped ZnO microflowers were fabricated using a low temperature hydrothermal method followed by heat treatment for the first time. The influence of the Ce dopant on the structural and photocatalytic properties was investigated.
Evaluation and optimization of biomarkers in a primary dysmenorrhea model using ultra performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry combined with a support vector machine
Authors: Fang Ling , Liu Xinyu , Zhang Zhenzhu , Li Aizhu , Deng Haoyue , Wang Lei , Hou Zhiguo , Gu Caiyun , Xu Yanyan , Li Yubo
Published: June 2015

A plasma metabolic profiling analysis method was established to find and optimize the potential biomarkers of a primary dysmenorrhea model.
Hydrothermal synthesis of hierarchical core–shell manganese oxide nanocomposites as efficient dye adsorbents for wastewater treatment
Authors: Wang Wei , Jiao Tifeng , Zhang Qingrui , Luo Xiaona , Hu Jie , Chen Yan , Peng Qiuming , Yan Xuehai , Li Bingbing
Published: June 2015

Hierarchical core–shell manganese oxide nanocomposites (Fe3O4@MnO2and Fe2O3@MnO2) are synthesizedviaa hydrothermal process and showed good adsorption capability for wide applications.
Nature of defects in blue light emitting CaZrO3: spectroscopic and theoretical study
Authors: Gupta Santosh K. , Ghosh P. S. , Pathak N. , Tewari R.
Published: June 2015

Defects responsible for intense blue emission in CaZrO3 are investigated using PL and EPR spectroscopy and complimented by DFT calculations.
The analysis of the changes in integration of nature of science into Turkish high school chemistry textbooks: is there any development?
Authors: Aydin Sevgi , Tortumlu Selma
Published: June 2015

To attain the goal of scientific literacy, the nature of science (NOS) is one of the areas that should be addressed. In many countries, the training of scientifically literate generations is a fundamental aim of science education, as a result there is an emphasis on NOS in science curricula and curricular materials. Textbooks prepared to teach curricula should incorporate aspects of NOS for all grades. In Turkey, the secondary science curricula were reformed in 2013. In this document analysis, aspects of NOS were included, the approach adopted for integrating aspects of NOS (i.e., explicit-reflective, implicit, and historical), and content-embeddedness of integration were analyzed in the reform-based and old high school chemistry textbooks published and provided by the National Ministry of Education. The results revealed that from the 9th to the 12th grade, the number of NOS aspects mentioned in the textbooks decreased. The most frequently cited aspects were the tentative nature of scientific knowledge, the empirical basis of science, and the difference between observation and inference. However, models in science, creativity and imagination were NOS aspects that were overlooked. Regarding the approach, contrary to the suggestion of the literature, the implicit approach was employed frequently. Finally, NOS aspects were provided in a content-embedded way in the 9th and 10th grades whereas they were presented mostly in a content-generic way in the 12th grade. Only the 9th grade textbook provided two NOS activities for teaching NOS. Although some changes have been made regarding teaching NOS, some important parts are missing. In light of the results, we suggest that all NOS aspects should be integrated into textbooks in an explicit-reflective way. Additionally, for teaching NOS, explicit-reflective activities should be offered in textbooks.
Possibility of designing catalysts beyond the traditional volcano curve: a theoretical framework for multi-phase surfaces
Authors: Wang Ziyun , Wang Hai-Feng , Hu P.
Published: June 2015

The current theory of catalyst activity in heterogeneous catalysis is mainly obtained from the study of catalysts with mono-phases, while most catalysts in real systems consist of multi-phases, the understanding of which is far short of chemists' expectation.
An integrally thin skinned asymmetric architecture design for advanced anion exchange membranes for vanadium flow batteries
Authors: Zhang Daishuang , Yan Xiaoming , He Gaohong , Zhang Le , Liu Xinhong , Zhang Fengxiang , Hu Mengmeng , Dai Yan , Peng Sangshan
Published: June 2015

We proposed an integrally thin skinned asymmetric anion exchange membrane with sufficiently low ion exchange capacity for vanadium flow batteries (VFBs), and this work provides new insights into the design, fabrication and commercialization of ion exchange membranes for VFBs.
Ag2O modified g-C3N4 for highly efficient photocatalytic hydrogen generation under visible light irradiation
Authors: Wu Ming , Yan Jun-Min , Zhang Xue-Wei , Zhao Ming , Jiang Qing
Published: June 2015

Ag2O/g-C3N4 shows a high hydrogen evolution rate from water splitting. It is much more efficient than g-C3N4 and Pt/g-C3N4.
Fabrication of nanocellulose–hydroxyapatite composites and their application as water-resistant transparent coatings
Authors: Ishikawa Mai , Oaki Yuya , Tanaka Yoshihisa , Kakisawa Hideki , Salazar-Alvarez German , Imai Hiroaki
Published: June 2015

Nanosized composite rods that were applicable to water-resistant transparent coatings were produced by deposition ofc-axis-oriented hydroxyapatite on cellulose nanocrystals.
Visualized acid–base discoloration and optoelectronic investigations of azines and azomethines having double 4-[N,N-di(4-methoxyphenyl)amino]phenyl terminals
Authors: Ma Bin-Bin , Zhang Hua , Wang Yu , Peng Yu-Xin , Huang Wei , Wang Ming-Kui , Shen Yan
Published: June 2015

MS-1 and MS-2 exhibit visualized acid–base discoloration, and MS-2 could be used as a low-cost HTM in perovskite solar cells.
A fluorescent probe with an aggregation-enhanced emission feature for real-time monitoring of low carbon dioxide levels
Authors: Wang Huan , Chen Didi , Zhang Yahui , Liu Pai , Shi Jianbing , Feng Xiao , Tong Bin , Dong Yuping
Published: June 2015

The presented method provides a facile and rapid approach to detect low levels of CO2 with high sensitivity, selectivity and reversibility.
How to induce highly efficient long-lasting phosphorescence in a lamp with a commercial phosphor: a facile method and fundamental mechanisms
Authors: Zou Zehua , Wu Jing , Xu Hua , Zhang Jiachi , Ci Zhipeng , Wang Yuhua
Published: June 2015

We successfully tailor the properties of a well-known commercial lamp with the Zn2SiO4:Mn2+ phosphor as a novel, highly efficient, long-lasting green phosphor by using the co-doping method.
Outcomes and Quality: Key Characteristics of a Successful SLP Value Journey
Authors: Rao Paul R.
Published: June 2015

We are living in a challenging era of healthcare reform marked by dramatic change and unprecedented political and legal turmoil surrounding this reform. Healthcare reform in the name of the Patient Protection and Affordable Care Act (PPACA, 2010) is becoming “hardwired” over the five years since its inception, yet as recently as March of 2015, the Supreme Court of the United States heard arguments to roll back subsidies for the Federal Health Exchanges which if approved could increase insurance rates by nearly 75% on over 8 million subscribers. The national healthcare landscape including reforms, changes, wins, and losses to date will be described. The “secret sauce” for meeting these challenges is to embrace value in healthcare which can be defined as outcomes over cost. In the context of our current levels of care, an inexorable movement away from volume to value will be described focusing on outcomes. The challenges we face especially in reporting outcomes and shifting from volume to value are described. Finally, arguments and illustrations are provided for how speech-language pathologists (SLPs) can continue to espouse value in becoming critical players in the value-based healthcare economy.
Intra‐cell and inter‐cell interference‐constrained D2D communication underlaying cellular networks
Authors: Zhang Xuefei , Tao Xiaofeng , Cui Qimei , Bai Juan
Published: June 2015

A multi‐cell joint optimisation problem is analysed to maximise the energy efficiency of the cellular and device‐to‐device (D2D) transmission, subject to a maximum power and signal‐to‐interference‐plus‐noise ratio constraint, under the scenario considering both intra‐cell and inter‐cell interference. On this basis, a multi‐cell joint power control (MCJPC) algorithm is proposed. For simpler implementation and lower coordination overhead, a single‐cell independent power control (SCIPC) algorithm is further proposed. The theoretical analysis and simulation results indicate that the proposed MCJPC and SCIPC algorithms can not only achieve higher energy efficiency compared with other typical power control algorithms, but also have good scalability.
Low insertion loss microplasma‐based limiter integrated into a microstrip bandpass filter
Authors: Pascaud R. , Pizarro F. , Callegari T. , Liard L. , Pigaglio O. , Pascal O.
Published: June 2015

The use of microplasma discharges as power‐induced limiter elements in microstrip devices is proposed to protect receivers against high‐power microwave threats. A microstrip bandpass filter integrating such a microplasma‐based active microwave power limiter has been designed and measured. Power limitation is observed when the input power exceeds 19 dBm with a leakage power of 14 dBm. Due to the gaseous properties of the active medium, the proposed structure exhibits a very low additional insertion loss of 0.06 dB.