bluuebunny/crossref_metadata_2025 huggingface dataset:
Infrastructuring European migration and border control: The logistics of registration and identification at Moria hotspot
Authors: Pollozek Silvan , Passoth Jan Hendrik
Published: March 2019

This paper examines Moria hotspot in Greece as a logistical site which fulfills two different functions within the European migration and border regime. It locates, contains, and sorts individuals locally at the external borders of the EU and creates, inserts, and processes data for controlling people on the move. Based on ethnographic fieldwork in Greece, including interviews with local administrators from the Registration and Identification Service, Médecins du Monde, Frontex and Hellenic Police and a collection of internal and publicly available planning, policy, and management documents and handbooks, the paper scrutinizes how both the movement of migrants and data is organized at the site. By developing an analytic lens of logistics, it outlines a specific mode of infrastructuring which aligns staff from different organizations with databases, devices, and migrants all in one place and organizes mundane practices such as filling out forms, taking fingerprints, signing, and entering datasets along a chain. That way the hotspot is able to locate, sort, and detain those who arrive at the hardened EU border and to create a data infrastructure for controlling, monitoring, and governing further movement by processing data through the bureaucratic channels of the EU’s transnational control assemblages.
Development of the Offender Personality Disorder Pathway: A summary of the underpinning evidence
Authors: Skett Sarah , Lewis Carine
Published: March 2019

The Offender Personality Disorder Pathway programme is a jointly commissioned initiative between NHS England and Her Majesty’s Prison & Probation Service (HMPPS), the aim of which is to provide a pathway of psychologically informed services for offenders who are likely to be diagnosed with personality disorder. This paper aims to describe the underpinning evidence behind the principles and expectations of services that make up the OPD pathway programme. Evidence of personality disorder treatments from mental health settings, as well as the evidence base from the criminal justice system and the Ministry of Justice’s ‘What Works?’ literature, is considered and draws together the evidence underlying critical elements of the programme. Research shows that there is no one treatment shown to be successful for the treatment of personality disorder. As such, a holistic approach is taken, with key components including trauma-informed approaches, a focus on relationship building, early identification and sentence planning, and the importance of workforce development and relationships.
Fidelity of a Teacher-Implemented Intervention for Preschoolers With Autism Spectrum Disorder: No, Some, and Unexpected Effects
Authors: Reszka Stephanie S. , Belardi Katie , Amsbary Jessica , Boyd Brian A. , Watson Linda R.
Published: March 2019

Advancing Social-Communication and Play (ASAP) is a classroom-based intervention targeting the social-communication and play development of preschool-age children with autism spectrum disorder. We used a multimethod approach to measuring intervention fidelity, including adherence, exposure, treatment differentiation, and quality of treatment delivery. Overall, teachers in the ASAP classrooms increased their adherence to the ASAP intervention compared with business-as-usual teachers. Teacher characteristics did not affect the ability to implement ASAP with fidelity. There were no group differences in coded video instructional quality scores. Differences in child engagement between the ASAP and business-as-usual groups were not mediated by fidelity adherence scores, contrary to our hypothesis. Finally, end-of-year summary of treatment delivery ratings did not align with adherence scores. Continued research regarding fidelity of school-based interventions should focus on distinguishing active ingredients from general instructional practices and learning from teachers about the child-level factors they consider when implementing an intervention.
Monitoring of impaired phagocytic function of Kupffer cells in an obstructive cholangitis rat model using superparamagnetic iron oxide MRI and contrast-enhanced ultrasound
Authors: Lee Jae Hwan , Kim Jung Hoon , Lee Seunghyun , Han Joon Koo
Published: March 2019

Background

Kupffer cells (KC) have an important role in the host defense in obstructive cholangitis. Non-invasive monitoring of phagocytic function of KC is pivotal. Several studies showed the possibility of non-invasive monitoring of phagocytic function of KC using superparamagnetic iron oxide-enhanced magnetic resonance imaging (SPIO-MRI) or contrast-enhanced ultrasound (CEUS).

Purpose

To investigate the serial change of KC function using SPIO-MRI and CEUS and whether the SPIO-MRI parameter correlates with the CEUS parameter in obstructive cholangitis rat models.

Material and Methods

With our institutional Animal Care and Use Committee approval, 19 rats (common bile duct ligation [CBDL]: n = 9; control: n = 10) underwent SPIO-MRI and CEUS at baseline, two, and four weeks after CBDL. The relative signal loss (RSL) of T2* value on SPIO-MRI and Kupffer phase parenchymal echogenicity (KPE) on CEUS were measured. The correlation between SPIO-MRI and CEUS parameters were compared with KC count.

Results

In CBDL group, RSL and KPE had significantly decreased (72.1% to 29.5%, 2.7 to 0.4) at four weeks compared with those in the control group (68.2% to 58.3%, 2.5 to 3.0, P < 0.05). During the follow-up period, RSL showed significantly positive correlations with KPE ( P = 0.007). In addition, at four weeks, we found RSL was positively correlated with KPE (ρ = 0.750, P = 0.002). KC count was negatively correlated to RSL and KPE at four weeks (ρ = −0.771, P = 0.001 and ρ = −0.644, P = 0.013).

Conclusion

SPIO-MRI and CEUS may be equally useful for monitoring the serial changes of KC phagocytic function in vivo.
Feline Hypertrophic Cardiomyopathy: The Consequence of Cardiomyocyte-Initiated and Macrophage-Driven Remodeling Processes?
Authors: Kitz Sarah , Fonfara Sonja , Hahn Shelley , Hetzel Udo , Kipar Anja
Published: March 2019

vHypertrophic cardiomyopathy (HCM) is the most commonly diagnosed cardiac disease in cats. The complex pathophysiology of HCM is still far from clear, but myocardial remodeling is a key process, and cardiomyocyte disarray, interstitial fibrosis, leukocyte infiltration, and vascular dysplasia are described histopathologic features. The present study systematically investigated the pathological processes in HCM, with the aim to shed more light on its pathogenesis. Hearts from 18 HCM cases and 18 cats without cardiac disease (controls) were examined, using light and transmission electron microscopy, immunohistochemistry, and morphometric approaches to identify and quantify the morphological changes. Reverse transcription–quantitative polymerase chain reaction was applied to provide additional mechanistic data on remodeling processes. In HCM, the left and right ventricular free wall and septal myocardium exhibited a significantly reduced overall cellularity, accompanied by a significant increase in interstitial Iba1-positive cells with macrophage morphology. In addition, the myocardium of almost half of the diseased hearts exhibited areas where cardiomyocytes were replaced by cell-rich fibrous tissue with abundant small and medium-sized vessels. HCM hearts also showed significantly higher transcription levels for several inflammatory and profibrotic mediators. Our findings suggest that HCM is the consequence of cardiac remodeling processes that are the result of cardiomyocyte damage and to which macrophages contribute by maintaining an inflammatory and profibrotic environment.
Analysis of Public Transportation Competitiveness Based on Potential Passenger Travel Intentions: Case Study in Shanghai, China
Authors: Li Linbo , Cao Mengfei , Bai Yufang , Song Ziqi
Published: March 2019

The primary goal of this paper is to identify the influence factors of public transportation (PT) competitiveness as related to potential passengers through an analysis of travel intentions. The logistic regression model is utilized to analyze PT travel intentions of people who commute daily by car in Shanghai, China. Through comparing the service quality of PT and of car from five aspects (i.e., comfort, timeliness, reliability, economics, and safety), the significant influence factors are identified. The results reveal that the difference in service quality between PT travel and car travel is insignificant for safety and convenience, while comfort, reliability, and economics matter most to the willingness to travel via PT. In addition, increasing the cost of car travel and improving the service quality of PT are both helpful in attracting car users to switch travel mode and enhancing PT competitiveness. The findings and suggestions will provide support to decisions in PT development policy making.
Side of Hamstring Harvest Does Not Affect Performance, Return-to-Sport Rate, or Future Hamstring Injuries After Ulnar Collateral Ligament Reconstruction Among Professional Baseball Pitchers
Authors: Erickson Brandon J. , Chalmers Peter N. , D’Angelo John , Ma Kevin , Ahmad Christopher S. , Dines Joshua S. , Romeo Anthony A.
Published: March 2019

Background:

Ulnar collateral ligament reconstruction (UCLR) is a successful procedure among professional baseball pitchers. It is unclear if hamstring tendon harvest side for UCLR affects the outcome or alters the risk for subsequent hamstring injury.

Hypothesis:

Players with prior UCLR with ipsilateral (drive leg) hamstring autograft will have the same return-to-sport (RTS) rate and performance upon RTS but a higher number of subsequent lower extremity injuries than those with contralateral (landing leg) hamstring autograft.

Study Design:

Cohort study; Level of evidence, 3.

Methods:

All players between 2010 and 2015 who underwent UCLR with hamstring autograft were included. Surgical details of their procedures were recorded from operative reports. Outcomes for UCLR with hamstring autograft harvested from the drive leg were compared with UCLR with the graft harvested from the landing leg.

Results:

Overall, 191 players underwent UCLR with hamstring autograft (drive leg, n = 58, 30%; landing leg, n = 133, 70%). The docking technique was more common in the drive leg group, while the figure-of-8 technique was more common in the landing leg group ( P > .001). More patients in the landing leg group underwent concomitant treatment of the ulnar nerve than the drive leg group ( P < .001). No difference existed in RTS rates or timing of RTS between groups. No differences in subsequent ipsilateral or contralateral hamstring injuries occurred between players who underwent UCLR with hamstring autograft from the drive leg or the landing leg ( P≥ .999 and P = .460, respectively). No difference in overall upper or lower extremity injury rates existed between groups (all P > .05), and no difference in performance metrics existed between groups upon RTS.

Conclusion:

No difference in RTS rate, performance upon RTS, or subsequent injury rates (hamstring, lower extremity, or upper extremity) existed between players who underwent UCLR with hamstring autograft whether the graft came from the drive or the landing leg.
The Relationship Between Living Alone and Self-Rated Health Varies by Age: Evidence From the National Health Interview Survey
Authors: Henning-Smith Carrie , Gonzales Gilbert
Published: March 2019

Despite growing attention to the connection between living arrangements and health, less is known about how the health of individuals living alone varies by age. Using data from the 2016 National Health Interview Survey ( N = 30,079), we estimated logistic regression models stratified by age group, comparing health by living arrangement and controlling for sociodemographic characteristics. Middle-aged adults living alone had higher odds of poor/fair self-rated health, compared with adults living with others (35-64 years of age: adjusted odds ratio [AOR] = 1.19, p < .05). In contrast, older adults (65 years and older) living alone had significantly lower odds of reporting poor/fair health than their counterparts living with others (AOR = .70, p < .001). The direction of association between self-rated health and other covariates did not differ by age group. The relationship between living alone and health varies by age and policies and programs designed to support the growing population of people living alone should be tailored accordingly.
Les dynamiques émotionnelles collectives. Perspectives pour le marketing
Authors: Didry Nico , Giannelloni Jean-Luc
Published: March 2019

Cet article s’intéresse aux dynamiques émotionnelles à l’œuvre lors d’une expérience collective. En cela il complète la littérature marketing sur les émotions, généralement abordées dans une perspective individuelle. Sa contribution est double. La première consiste à identifier, définir et caractériser les principaux concepts relatifs aux émotions vécues en contexte collectif. Pour cela, une revue de la littérature en psychologie, psychologie sociale et sociologie a été effectuée. Nous allons au-delà de cette littérature en distinguant les processus de transferts émotionnels des états émotionnels collectifs résultants de ces transferts. La seconde contribution consiste à montrer que la littérature marketing aborde rarement ces sujets, et le fait de façon partielle en se focalisant sur la relation dyadique vendeur–acheteur. Des propositions de recherche axées sur les perspectives d’intégration des dynamiques émotionnelles collectives dans la recherche marketing sont ensuite formulées.
Comment l’autonomie rend-elle une expérience agréable ? Les rôles de la perception du risque et du contrôle personnel
Authors: Lunardo Renaud , Saintives Camille
Published: March 2019

Résumé

Cette recherché remet en cause l’idée selon laquelle l’autonomie est bénéfique pour les consommateurs quelle que soit la situation. Plus précisément, cette recherche démontre, à travers deux expérimentations et une étude terrain, que l’autonomie ne donne lieu à du plaisir que lorsque le risque est faible. Ces études identifient également le contrôle personnel comme un mécanisme expliquant pourquoi l’autonomie rend la consommation plus ou moins agréable, et ce, en fonction de la perception du risque. Dans l’étude 1, nous démontrons que le risque perçu modère l’effet que l’autonomie peut avoir sur le fait de rendre une expérience agréable, l’absence de risque permettant à l’autonomie d’accroître le contrôle personnel. L’étude 2 réplique cet effet modérateur du risque au cours d’une étude terrain. Pour tester si de mêmes effets peuvent être retrouvés avec un autre type de risque perçu, l’étude 3 manipule le risque social et réplique l’effet modérateur du risque dans la relation entre autonomie, contrôle personnel et plaisir observé dans les études 1 et 2. D’une manière générale, cette recherche met en avant la nécessité de prendre en considération le risque lorsqu’on rend les consommateurs autonomes, et offre de nouvelles contributions aux recherches sur l’autonomie des consommateurs.
Crystal Balls and Black Boxes: What Makes a Good Forecast?
Authors: Voulgaris Carole Turley
Published: March 2019

As a discipline that concerns itself with the future, planning relies on forecasts to inform and guide action. With this reliance comes a concern that the best possible forecasts be produced. This review identifies three distinct ways in which forecasts may be evaluated (methodology, accuracy, and usefulness) and describes challenges associated with evaluating forecasts along any of these three dimensions. By way of example, this general discussion of forecasting is applied to the specific case of demand forecasts for transportation infrastructure, with an emphasis on transit infrastructure. There is a continuing need for planners to engage with interdisciplinary forecasting literature.
The Role of Social Support in Identity Processes and Posttraumatic Growth: A Study of Victims of Intimate Partner Violence
Authors: Žukauskienė Rita , Kaniušonytė Goda , Bergman Lars R. , Bakaitytė Aistė , Truskauskaitė-Kunevičienė Inga
Published: March 2019

The purpose of this study was to explore the role of social support for posttraumatic growth (PTG) and identity processes in a sample of 217 women victims of intimate partner violence (IPV), recruited from women shelters, social support centers, and through counseling psychologists. The results of the study highlight the important role of social support in seeking positive personal resolutions after experiencing traumatic events of IPV. It indicates that social support, but not social nonsupport, predicts higher levels of PTG and the development of new positive identities. In particular, social support was positively associated with the manifestation of all five identity processes, that is, with identification with commitment, commitment making, exploration in breadth, exploration in depth, and ruminative exploration. Furthermore, contextual and socioeconomic factors, such as time after last violence, relationships with the perpetrator, place of residence, education, and age of the victims of IPV were also related to identity processes. Severity of the violence, time after the last violence, education, and personal income were related to PTG. Thus, this study indicated that there are significant contextual and socioeconomic differences in the PTG and reconsideration of one’s identity. Recommendations for practitioners and future research have been suggested.
Disaggregating Violence: Understanding the Decline
Authors: Skott Sara
Published: March 2019

Although trends of violent crime have been examined for over a century, no previous study has examined the change of subtypes of violence over time. This study therefore aims to identify subtypes of violence in Scotland, where violence levels have decreased from one of the highest in Europe to one of the lowest, based on variables relating to the victim, offender, and incident, and to examine how these subtypes have changed over time. Four main types of violence were identified using multilevel latent class analysis on Scottish Crime and Justice Survey data: public no weapon, public weapon, work-related, and domestic. The findings show that although all types of violence have demonstrated an absolute decrease over time, Domestic and work-related violence have demonstrated relative increases over time. The findings are discussed in relation to the inequality of this decrease and propose guidelines for future prevention policies.
Intelligent PD controller design for active suspension system based on robust model-free control strategy
Authors: Haddar Maroua , Chaari Riadh , Baslamisli S Caglar , Chaari Fakher , Haddar Mohamed
Published: March 2019

A novel active suspension control design method is proposed for attenuating vibrations caused by road disturbance inputs in vehicle suspension systems. For the control algorithm, we propose an intelligent PD controller structure that effectively rejects online estimated disturbances. The main theoretical techniques used in this paper consist of an ultra-local model which replaces the mathematical model of quarter car system and a new algebraic estimator of unknown information. The measurement of only input and output variables of the plant is required for achieving the reference tracking task and the cancellation of unmodeled exogenous and endogenous perturbations such as roughness road variation, unpredictable variation of vehicle speed and load variation. The performance and robustness of the proposed active suspension algorithm are compared with ADRC control and LQR control. Numerical results are provided for showing the improvement of passenger comfort criteria with model-free control.
Creeping control strategy for Direct Shift Gearbox based on the investigation of temperature variation of the wet multi-plate clutch
Authors: Wu Jianpeng , Ma Biao , Li Heyan , Liu Jikai
Published: March 2019

Proposing an appropriate control strategy is an effective and practical way to address the overheat problems of the wet multi-plate clutches in Direct Shift Gearbox under the long-time creeping condition. To do so, the temperature variation of the wet multi-plate clutch is investigated first by establishing a thermal resistance model for the gearbox cooling system. To calculate the generated heat flux and predict the clutch temperature precisely, the friction torque model is optimized by introducing an improved friction coefficient, which is related to the pressure, the relative speed and the temperature, before being demonstrated experimentally using a full scale powertrain test. After that, the verified heat transfer model and the reasonable friction torque model are employed by the vehicle powertrain model to construct a comprehensive co-simulation model for the Direct Shift Gearbox vehicle, capable of simulating the dynamic responses and predicting the temperature variations of two clutches. A creeping control strategy is then proposed and, to evaluate the vehicle performance, the safety temperature (250°C) is particularly adopted as an important metric. From the variations in torque and speed obtained from the simulation results, the vehicle can track the desired speed (1.5 km/h) satisfactorily, with only 3% fluctuation, and have good longitudinal dynamic performance (8.5 m/s3). But above all, during the entire 174 s creeping process, the temperature of two clutches is always under the safety value (250°C), which demonstrates the effectiveness of the proposed control strategy in avoiding the thermal failures of clutches.
Dynamical analysis of B-train vehicle combination with liquid cargo
Authors: Barbieri Nilson , de Melo Rubem Penteado , de Lima Key Fonseca , Barbieri Gabriel de Sant’Anna Vitor
Published: March 2019

In this work, a combination of B-train type vehicle is dynamically analysed through lateral movement at low speed manoeuvre known as Lane Change Manoeuvre. The analyses were conducted for a vehicle with liquid loads of 100%, 80%, 60% and 40% capacity. The analyses involve adjusting the steer angle through an objective function taking into account the numerical and experimental lateral acceleration of the tractor vehicle. The movement of the liquid (slosh) during the manoeuvres are approximated using the software Pasimodo and trammel pendulum. Considering the upper surface of the liquid inside the tank as a straight line, it is possible to obtain the centre of gravity variation and the moment of inertia through polynomial adjustments. In this way, it is possible to analyse numerically the behaviour of the vehicle with liquid load in a curved trajectory. To obtain modal parameters, the operational modal analysis technique is used. With the applied methodology, it was possible to find good agreement between the numerical and experimental values of the acceleration signals in four different positions in the vehicle combination. Through the analyses of the vehicle with fluid in movement, it was possible to verify a great variation of load in the wheels due to transfer of load of the vehicle travelling by curved trajectories or due to evasive manoeuvres. This is a critical condition that can lead the vehicle to rollover condition. The experimental data were obtained for the vehicle at constant speed (between 30 and 40 km/h) and under these conditions, the vehicle is considered stable by analysing the eigenvalues.
Analysis of hybrid statistical textural and intensity features to discriminate retinal abnormalities through classifiers
Authors: Balasubramanian Kishore , Ananthamoorthy N P
Published: March 2019

Retinal image analysis relies on the effectiveness of computational techniques to discriminate various abnormalities in the eye like diabetic retinopathy, macular degeneration and glaucoma. The onset of the disease is often unnoticed in case of glaucoma, the effect of which is felt only at a later stage. Diagnosis of such degenerative diseases warrants early diagnosis and treatment. In this work, performance of statistical and textural features in retinal vessel segmentation is evaluated through classifiers like extreme learning machine, support vector machine and Random Forest. The fundus images are initially preprocessed for any noise reduction, image enhancement and contrast adjustment. The two-dimensional Gabor Wavelets and Partition Clustering is employed on the preprocessed image to extract the blood vessels. Finally, the combined hybrid features comprising statistical textural, intensity and vessel morphological features, extracted from the image, are used to detect glaucomatous abnormality through the classifiers. A crisp decision can be taken depending on the classifying rates of the classifiers. Public databases RIM-ONE and high-resolution fundus and local datasets are used for evaluation with threefold cross validation. The evaluation is based on performance metrics through accuracy, sensitivity and specificity. The evaluation of hybrid features obtained an overall accuracy of 97% when tested using classifiers. The support vector machine classifier is able to achieve an accuracy of 93.33% on high-resolution fundus, 93.8% on RIM-ONE dataset and 95.3% on local dataset. For extreme learning machine classifier, the accuracy is 95.1% on high-resolution fundus, 97.8% on RIM-ONE and 96.8% on local dataset. An accuracy of 94.5% on high-resolution fundus 92.5% on RIM-ONE and 94.2% on local dataset is obtained for the random forest classifier. Validation of the experiment results indicate that the hybrid features can be deployed in supervised classifiers to discriminate retinal abnormalities effectively.
An experimental evaluation of fracture movement in two alternative tibial fracture fixation models using a vibrating platform
Authors: Moazen Mehran , Calder Peter , Koroma Paul , Wright Jonathan , Taylor Stephen , Blunn Gordon
Published: March 2019

Several studies have investigated the effect of low-magnitude-high-frequency vibration on the outcome of fracture healing in animal models. The aim of this study was to quantify and compare the micromovement at the fracture gap in a tibial fracture fixed with an external fixator in both a surrogate model of a tibial fracture and a cadaver human leg under static loading, both subjected to vibration. The constructs were loaded under static axial loads of 50, 100, 150 and 200 N and then subjected to vibration at each load using a commercial vibration platform, using a DVRT sensor to quantify static and dynamic fracture movement. The overall stiffness of the cadaver leg was significantly higher than the surrogate model under static loading. This resulted in a significantly higher fracture movement in the surrogate model. Under vibration, the fracture movements induced at the fracture gap in the surrogate model and the cadaver leg were 0.024 ± 0.009 mm and 0.016 ± 0.002 mm, respectively, at 200 N loading. Soft tissues can alter the overall stiffness and fracture movement recorded in biomechanical studies investigating the effect of various devices or therapies. While the relative comparison between the devices or therapies may remain valid, absolute magnitude of recordings measured externally must be interpreted with caution.
A Big Data implementation of the MANTIS reference architecture for predictive maintenance
Authors: Larrinaga Felix , Fernandez-Anakabe Javier , Zugasti Ekhi , Garitano Iñaki , Zurutuza Urko , Olaizola Jon , Anasagasti Mikel , Mondragon Mikel
Published: March 2019

This article presents the implementation of a reference architecture for cyber-physical systems to support condition-based maintenance of industrial assets. It also focuses on describing the data analysis approach to manage predictive maintenance of clutch-brake assets fleet over the previously defined MANTIS reference architecture. Proposals for both the architecture and data analysis implementation support working on Big Data scenarios, due to the usage of related technologies, such as Hadoop Distributed File System, Kafka or Apache Spark. The techniques are (1) root cause analysis powered by attribute-oriented induction clustering and (2) remaining useful life powered by time series forecasting. The work has been conducted in a real use case within the H2020 European project MANTIS.
Performance of SLEDAI-2K to detect a clinically meaningful change in SLE disease activity: a 36–month prospective cohort study of 334 patients
Authors: Jesus D , Rodrigues M , Matos A , Henriques C , Pereira da Silva J A , Inês L S
Published: March 2019

Objective

The objective of this paper is to evaluate the performance of the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI-2K) in detecting clinically meaningful changes in SLE disease activity.

Methods

A longitudinal cohort study was conducted of 334 SLE patients during a 36-month follow-up. At each outpatient visit, disease activity was scored using the Physician Global Assessment (PGA) and SLEDAI-2K. Correlations between PGA and SLEDAI-2K were assessed. A clinically meaningful change in SLE disease activity was defined as a ΔPGA ≥ 0.3 points from baseline. Performance of SLEDAI-2K in detecting a clinically meaningful worsening or improvement was tested using receiver operating characteristic (ROC) analysis.

Results

Adjusted mean PGA and SLEDAI-2K scores presented a high correlation (rho = 0.824, p < 0.0005). In ROC analysis, a SLEDAI-2K variation presented an area under the curve (AUC) of 0.697 (95% confidence interval (CI) (0.628–0.766), p < 0.0005) to detect a clinically meaningful improvement, with a sensitivity of 28.8% for a SLEDAI-2K ≥ 4 reduction. The AUC to detect a clinically meaningful worsening was 0.877 (95% CI (0.822–0.932), p < 0.0005), with a sensitivity of 35.3%.

Conclusions

SLEDAI-2K has a limited ability to detect clinically meaningful changes in SLE disease activity, failing to identify almost two-thirds of cases judged as having a clinically meaningful improvement or worsening. There is a need for more sensitive SLE disease activity measures in clinical practice and research.
Design, modeling, and evaluation of a slim haptic actuator based on electrorheological fluid
Authors: Mazursky Alex , Koo Jeong-Hoi , Yang Tae-Heon
Published: March 2019

Realistic haptic feedback is needed to provide information to users of numerous technologies, such as virtual reality, mobile devices, and robotics. For a device to convey realistic haptic feedback, two touch sensations must be present: tactile feedback and kinesthetic feedback. Although many devices today convey tactile feedback through vibrations, most neglect to incorporate kinesthetic feedback. To address this issue, this study investigates a haptic device with the aim of conveying both kinesthetic and vibrotactile information to users. A prototype based on electrorheological fluids was designed and fabricated. By controlling the electrorheological fluid flow via applied electric fields, the device can generate a range of haptic sensations. The design centered on an elastic membrane that acts as the actuator’s contact surface. Moreover, the control electronics and structural components were integrated into a compact printed circuit board, resulting in a slim device suitable for mobile applications. The device was tested using a dynamic mechanical analyzer to evaluate its performance. The device design was supported with mathematical modeling and was in agreement with experimental results. According to the just-noticeable difference analysis, this range is sufficient to transmit distinct kinesthetic and vibrotactile sensations to users, indicating that the electrorheological fluid–based actuator is capable of conveying haptic feedback.
Contributions of Neuroscience Knowledge to Teachers and Their Practice
Authors: Dubinsky Janet M. , Guzey S. Selcen , Schwartz Marc S. , Roehrig Gillian , MacNabb Carrie , Schmied Astrid , Hinesley Vicki , Hoelscher Mary , Michlin Michael , Schmitt Lee , Ellingson Charlene , Chang Zhengsi , Cooper Janice L.
Published: March 2019

While neuroscience has elucidated the mechanisms underpinning learning and memory, accurate dissemination of this knowledge to teachers and educators has been limited. This review focuses on teacher professional development in neuroscience that harnessed the power of active-learning strategies and best educational practices resulting in increased teacher and student understanding of cognition and brain function. For teachers, the experience of learning a novel subject in an active manner enabled them to subsequently teach using similar strategies. Most important, participants viewed neuroscience as a frame for understanding why active-learning pedagogies work to engage and motivate students. Teachers themselves made connections applying neuroscience concepts to understand why learner-centered pedagogies are effective in promoting higher order thinking and deep learning in their students. Teachers planned and embraced pedagogies involving modeling, experimentation, discussion, analysis, and synthesis, increasing classroom cognitive engagement. Comprehending that everyone is in charge of changing their own brains is a tremendously powerful idea that may motivate science and non-science teachers to provide students opportunities to actively engage with content. Neuroscience courses for preservice and in-service teachers, provided as collaborations between scientists and teacher educators, can result in improved science education, pedagogy, and understanding of neuroscience.
Examining the Growth of Sports Communication Programs in Higher Education Through a Questionnaire of Program Coordinators
Authors: Hull Kevin , Choi Minhee , Kian Edward (Ted) M.
Published: March 2019

As higher education institutions seek ways to attract, recruit, and retain students, some schools and colleges are creating sports communication or related programs. Using the student–customer model of higher education as a theoretical lens, this study questioned coordinators of those programs regarding their opinions of this quickly growing field. Results demonstrate that student interest, administrative and financial support, and having resources already in place before designing curricula are keys to building and sustaining successful sports communication academic programs. Results of this study can be used by schools looking to launch sports communication programs.
Chimeric antigen receptor T-cell therapy: Foundational science and clinical knowledge for pharmacy practice
Authors: Dushenkov Anna , Jungsuwadee Paiboon
Published: March 2019

The Food and Drug Administration has recently approved two autologous chimeric antigen receptor T-cell immunotherapies tisagenlecleucel (Kymriah™) and axicabtagene ciloleucel (Yescarta™) for patients with advanced lymphocytic malignancies. Both immunotherapies target the CD19-positive B-cell neoplasms. Kymriah™ is indicated for the treatment of relapsed or refractory acute lymphoblastic leukemia and large B-cell lymphoma. Yescarta™ is indicated for lymphoma only. Although the new therapy offers a promise for patients with advanced disease, it is associated with adverse events including neurotoxicity and cytokine release syndrome, which can be fatal and may require a high level of multidisciplinary supportive care. Due to the risks, both Kymriah™ and Yescarta™ are subject to Risk Evaluation and Mitigation Strategy (REMS) protocols. As active members of multidisciplinary clinical teams, pharmacists are likely to be responsible for the execution of Kymriah™ and Yescarta™ REMS programs. This manuscript describes foundational science and clinical knowledge of chimeric antigen receptor T-cell immunotherapies, common therapy-specific toxicities and REMS requirements for Kymriah™ and Yescarta™ in relation to practice of pharmacy.
Understanding the Diverse Scaling Strategies of Social Enterprises as Hybrid Organizations: The Case of Renewable Energy Cooperatives
Authors: Bauwens Thomas , Huybrechts Benjamin , Dufays Frédéric
Published: March 2019

This article seeks to shed light on the diversity of scaling strategies of social enterprises, which can be considered as emblematic hybrid organizations. By comparing three Flemish renewable energy cooperatives with contrasted scaling strategies, the article shows how these strategies can be understood in relation to the organizational mission as imprinted at the founding. We extend the notion of hybridity beyond the combination of institutional logics to highlight the interest orientation (mutual vs. general interest). Unlike what is suggested in extant literature, we find that mutual interest orientation may be associated with “scale-up,” business growth strategies, while general interest orientation may lead to less growth-focused “scale-out” and “scale-deep” strategies. The findings illuminate aspects of the hybrid nature of social enterprises by explaining their diverse scaling strategies and extend the notion of imprinting to the interorganizational level by highlighting how social enterprises may collaborate to collectively achieve the pursuit of their multiple missions.
Chinese business migrants in Australia: Middle-class transnationalism and ‘dual embeddedness’
Authors: Colic-Peisker Val , Deng Ling
Published: March 2019

Over the past two decades, four-fifths of the business immigration to Australia originated from China. Australian business migrants are required to undertake a two-step migration pathway: first they demonstrate a certain level of assets and business success to qualify for temporary entry and then, through successful business activity, they qualify for permanent residency (PR). Using in-depth interview narratives and survey data, this article explores migration motives and experiences of Chinese business migrants in Melbourne, Australia and situates them within the conceptual framework of middle-class transnationalism and ‘dual embeddedness’. We found that our respondents were primarily driven by motives other than the likelihood of business success in Australia, such as the prospects of good education for their children and a cleaner environment. Gaining Australian PR emerged as the key milestone in the migration process, allowing migrants to move freely between home and host countries and live as ‘dually embedded’ transnationals.
All work and no play: A text analysis
Authors: Downer Kate , Wells Chrissie , Crichton Charlotte
Published: March 2019

Automated analysis of open-ended text survey data is an appealing prospect. It eliminates human error and human variability and can be used to create models that are easier to update over time than a manual approach to coding generally yields. Today, text analytics is a huge business and is among the most popular innovations within the current research landscape. However, within the research industry, there has been little change in usage in recent years, and awareness of the options available appears to be limited. We wished to look more closely at the true strengths of different approaches, the main barriers to their adoption, and how these might be overcome. Using text responses from a short survey about work and play in two markets, we contrasted two tools in analyzing the output: Q’s text analysis component and Google Cloud Natural Language. We chose these tools as they can each be easily applied to survey data but are based on different analytic principles. We found some surprising differences between the output of the two tools and between the text analysis metrics and scalar data. We conclude by discussing some of the key contemporary themes in text analytics and the likely future role of this method within market research and insight.
A Multidisciplinary Survey to Assess Facilitators and Barriers to Successful Organ Donation in the Intensive Care Unit
Authors: Oczkowski Simon J. W. , Durepos Pamela , Centofanti John , Arsenau Erika , Dhanani Sonny , Cook Deborah J. , Meade Maureen O.
Published: March 2019

Introduction:

Rates of successful organ donation vary between otherwise comparable intensive care units (ICUs). The ICU staff have a unique perspective into the facilitators and barriers underlying this variation in successful deceased organ donation.

Research Question:

What do ICU staff perceive to be the most meaningful facilitators and barriers to deceased organ donation?

Design:

We designed and conducted a survey of all disciplines working in the ICU to ascertain the perceived facilitators and barriers to donation in an academic tertiary care hospital. Survey reliability was assessed using Cronbach α. Factor analysis was used to assess construct validity and identify potentially redundant survey items.

Results:

We had responses from 108 ICU staff, including nurses (n = 75), respiratory therapists (n = 14), physicians (n = 12), chaplains (n = 2), as well as social work, pharmacy, physiotherapy, and occupational therapy (n = 1 each). Perceived facilitators included availability of organ donation organization coordinators, explicit institutional support for donation, ICU staff culture toward donation, standardized order sets for donation, presence of ICU staff with donation experience, and bedside nurse presence at discussions about donation. Perceived barriers included ICU staff ruling out potentially suitable donors before consulting a donor coordinator, physician communication skills, low priority for organ donation among operating room staff, limited family understanding of patient prognosis and organ donation, and limited emotional readiness of families to discuss donation.

Discussion:

Several staff-perceived facilitators and barriers to deceased organ donation were identified in the ICU. Future research could identify strategies to promote these facilitators and overcome barriers.
The Role of Spiritual Care with the Introduction of an End of Life Order Set
Authors: Stilos Kalli , Ford Bill , Lilien Tammy , Moore Jennifer
Published: March 2019

Delivering comprehensive end-of-life care to dying patients must involve addressing physical symptoms and psychosocial concerns. Care pathways have been introduced to support health care teams in delivering this care. This retrospective chart review explores the contributions of the Spiritual Care Team in the care of dying patients. They offer a range of interventions which include supportive care, religious and spiritual support. This study was one step towards appreciating the contributions of the Spiritual Care Team.
Suffering for Others While Making Others Suffer: Military Narratives of Sacrifice
Authors: Grimell Jan
Published: March 2019

Voices from theology seldom participate in a contemporary conversation on military cultures and identities; this article attempts to stimulate this conversation from such a perspective. The article combines a literature review with narratives of sacrifice from real-life cases. It presents a reflective perspective on the formation of military identities with regard to responsibilities and sacrifices. Forgiveness and atonement are discussed as pathways to cultivate growth which can lessen feelings of guilt and regret.
On Life After Death: A Chaplain’s View on the Process of Dying
Authors: Kaldahl Jeffrey
Published: March 2019

Elizabeth Kubler-Ross wrote the book On Life After Death to give her findings on what happens when a person dies. Over the course of 20 years, she found that no matter age, sex, religion, or culture, everyone spoke of the same things happening upon death. The insights and revelations that Kubler-Ross talks about will give a minister help when they speak with someone who is dying or has had a near-death experience.
Efficacy of New Polylactic Acid Nonwoven Fabric as a Hemostatic Agent in a Rat Liver Resection Model
Authors: Wakabayashi Taiga , Yagi Hiroshi , Tajima Kazuki , Kuroda Kohei , Shinoda Masahiro , Kitago Minoru , Abe Yuta , Oshima Go , Hirukawa Kazuya , Itano Osamu , Kitagawa Yuko
Published: March 2019

Background. During minimally invasive surgery, efficient and nontoxic hemostats are important for difficult to access bleeding areas. Polylactic acid is an ecofriendly hemostatic agent and we aimed to evaluate the efficacy of a polylactic acid nonwoven fabric (PLAF) developed by Toray Industries, Inc, on liver hemostasis in a preclinical study. Materials and Methods. PLAF consists of both 1-µm diameter fibers and 100-µm diameter beaded fibers. Four rats were used, and 2 trough-shaped resections of the liver parenchyma were performed (n = 8 lobes). Immediately after the resection, PLAF (PLAF group: n = 4 lobes) or rayon gauze (Rayon group: n = 4 lobes) were applied on the resected plane and compressed manually. We compared the mean time to hemostasis and blood loss per lobe, as well as histological findings between the groups. Results. The PLAF group had a significantly shorter bleeding time ( P = .006), and showed lower blood loss compared with the Rayon group ( P = .076). Histopathological evaluation showed a large amount of beads on the liver surface in the PLAF group. Aggregated red blood cells evident by electron microscopy and von Willebrand factor immunofluorescence were seen surrounding the beads. The PLAF group showed significantly greater von Willebrand factor expression than the Rayon group ( P = .004). Discussion. This new PLAF showed superior outcomes thanks to its unique characteristic of forming beaded nanofibers, and it has the potential to be an efficient hemostat in minimally invasive surgery in the human body.
Precision Medicine in Lifestyle Medicine: The Way of the Future?
Authors: Gray Ian D. , Kross Andrea R. , Renfrew Melanie E. , Wood Paul
Published: March 2019

Precision medicine has captured the imagination of the medical community with visions of therapies precisely targeted to the specific individual’s genetic, biological, social, and environmental profile. However, in practice it has become synonymous with genomic medicine. As such its successes have been limited, with poor predictive or clinical value for the majority of people. It adds little to lifestyle medicine, other than in establishing why a healthy lifestyle is effective in combatting chronic disease. The challenge of lifestyle medicine remains getting people to actually adopt, sustain, and naturalize a healthy lifestyle, and this will require an approach that treats the patient as a person with individual needs and providing them with suitable types of support. The future of lifestyle medicine is holistic and person-centered rather than technological.
Pipeline embolization device implantation in large carotid cavernous aneurysm associated with situs inversus totalis
Authors: Chakravarthi Sudheer , Oishi Hidenori , Yatomi Kenji , Teranishi Kohsuke
Published: March 2019

Situs anomalies are a heterogenous class of inborn visceral and vascular abnormalities with a broad range of radiographic characteristics. Situs inversus totalis is characterized by mirror image location of the heart and viscera relative to situs solitus (normal position). Few aberrations involving the neuraxis, and rarely intracranial aneurysms, have been reported in association with situs inversus totalis. We describe the radiological findings and endovascular management of one of the first of its kind: the association of bilateral carotid cavernous aneurysms (one large and the other small-sized) with situs inversus totalis.