bluuebunny/crossref_metadata_2025 huggingface dataset:
Poor People Are Hospitalized Three Times More for Mental Health Services than the Non-Poor in Central Valley California
Authors: Lama Gyanesh , Alcala Emanuel , Capitman John
Published: January 2018

Introduction: Providing health insurance to the poor has become a standard policy response to health disparities between the poor and the non-poor. It is often assumed that if the poor people are given health insurance, they will use preventative care, which will prevent more expensive emergency visits and inpatient hospitalization, and in turn, it will save healthcare cost in the long run. This paper presents the findings from our study in California about what happens to the poor when they are given health insurance. The purpose of the study was to understand how the healthcare system in California treats the poor patients differently than the non-poor. Method: Using multivariate logistic regressions, this study analyzed a large patient discharge data (PDD) from the California Office of Statewide Planning and Development (OSHPD) for eight counties in the Central Valley California (N = 423,640). First, utilizing International Classification of Diseases (ICD 10) as diagnostic criteria, mental-health vs. non-mental health hospitalization rates were estimated. Second, health insurance status was used as a proxy measure of poverty of the patients. Using chi-Square, the probability of hospitalization for mental health services was estimated based on their insurance types. Finally, using step-wise logistic regression, the odds of mental health hospitalization was estimated conditional on individual characteristics, health insurance types, and geographic characteristics. Findings: When the poor people were given health insurance, they were three times more likely to be hospitalized for mental health services than the non-poor. The more than three-fold variation in mental health hospitalization was not driven by demographic or geographic characteristics. The findings are new and have important implications for the healthcare policies for the poor. Further studies are needed to understand the extent to which the disproportionately high rate of mental health hospitalizations of the poor are driven by the provider-induced needs.
Estimating Aquifer Storage and Recovery (ASR) Regional and Local Suitability: A Case Study in Washington State, USA
Authors: Gibson Maria , Campana Michael , Nazy Dave
Published: January 2018

Developing aquifers as underground water supply reservoirs is an advantageous approach applicable to meeting water management objectives. Aquifer storage and recovery (ASR) is a direct injection and subsequent withdrawal technology that is used to increase water supply storage through injection wells. Due to site-specific hydrogeological quantification and evaluation to assess ASR suitability, limited methods have been developed to identify suitability on regional scales that are also applicable at local scales. This paper presents an ASR site scoring system developed to qualitatively assess regional and local suitability of ASR using 9 scored metrics to determine total percent of ASR suitability, partitioned into hydrogeologic properties, operational considerations, and regulatory influences. The development and application of a qualitative water well suitability method was used to assess the potential groundwater response to injection, estimate suitability based on predesignated injection rates, and provide cumulative approximation of statewide and local storage prospects. The two methods allowed for rapid assessment of ASR suitability and its applicability to regional and local water management objectives at over 280 locations within 62 watersheds in Washington, USA. It was determined that over 50% of locations evaluated are suitable for ASR and statewide injection potential equaled 6400 million liters per day. The results also indicate current limitations and/or potential benefits of developing ASR systems at the local level with the intent of assisting local water managers in strategic water supply planning.
Socioeconomic Inequalities in the Use of Healthcare Services: Comparison between the Roma and General Populations in Spain
Authors: La Parra-Casado Daniel , Mosquera Paola , Vives-Cases Carmen , San Sebastian Miguel
Published: January 2018

This paper explores whether the principles of horizontal and vertical equity in healthcare are met by the Spanish national health system in the case of the Roma and general populations. The 2011/2012 Spanish National Health Survey (n = 21,650) and the 2014 National Health Survey of the Spanish Roma Population (n = 1167) were analyzed. Use of healthcare services was measured in terms of visits to a general practitioner (GP), visits to an emergency department, and hospitalizations. Healthcare need was measured using (a) self-rated health and (b) the reported number of chronic diseases. The Roma reported worse self-rated health and a higher prevalence of chronic diseases. A redistributive effect (increased healthcare service use among Roma and those in lower socio-economic classes) was found for hospitalizations and emergency visits. This effect was also observed in GP visits for women, but not for men. Vertical inequity was observed in the general population but not in the Roma population for GP visits. The results suggest the existence of horizontal inequity in the use of GP services (Roma women), emergency department visits (Roma and general population), and hospitalizations (Roma population) and of vertical inequity in the use of GP services among the general population.
A Cross-Sectional Study of the Association between Infant Hepatitis B Vaccine Exposure in Boys and the Risk of Adverse Effects as Measured by Receipt of Special Education Services
Authors: Geier David , Kern Janet , Homme Kristin , Geier Mark
Published: January 2018

The National Center for Education Statistics reported that between 1990–2005 the number of children receiving special education services (SES) rose significantly, and then, from 2004–2012, the number declined significantly. This coincided with the introduction of Thimerosal-containing hepatitis B vaccine in 1991, and the subsequent introduction of Thimerosal-reduced hepatitis B vaccine in the early 2000s. This study examined the potential relationship between infant exposure to mercury from three doses of Thimerosal-containing hepatitis B vaccine and the risk of boys being adversely affected (as measured by receipt of SES). This cross-sectional study examined 1192 boys (weighted n = 24,537,123) 7–8 years of age (born: 1994–2007) from the combined 2001–2014 National Health and Nutritional Examination Survey (NHANES). Survey logistic regression modeling revealed that an exposed population receiving three doses of infant Thimerosal-containing hepatitis B vaccine (weighted n = 11,186,579), in comparison to an unexposed population (weighted n = 704,254), were at an increased risk of receipt of SES. This association was robust (crude odds ratio = 10.143, p = 0.0232), even when considering covariates, such as race and socioeconomic status (adjusted odds ratio = 9.234, p = 0.0259). Survey frequency modeling revealed that receipt of SES for the population that was exposed to three doses of Thimerosal-containing hepatitis B vaccine in infancy (12.91%) was significantly higher than the unexposed population (1.44%) (prevalence ratio = 8.96, p = 0.006, prevalence attributable rate = 0.1147). Despite the limitation of this cross-sectional study not being able to ascribe a direct cause-and-effect relationship between exposure and outcome, it is estimated that an additional 1.2 million boys received SES with excess education costs of about United States (US) $180 billion associated with exposure to Thimerosal-containing hepatitis B vaccine. By contrast, exposure to Thimerosal-reduced hepatitis B vaccine was not associated with an increased risk of receiving SES. Therefore, routine childhood vaccination is important to reduce the morbidity and mortality of infectious diseases, but every effort should be made to eliminate Thimerosal from all vaccines.
Effect of Radiological Countermeasures on Subjective Well-Being and Radiation Anxiety after the 2011 Disaster: The Fukushima Health Management Survey
Authors: Murakami Michio , Takebayashi Yoshitake , Takeda Yoshihito , Sato Akiko , Igarashi Yasumasa , Sano Kazumi , Yasutaka Tetsuo , Naito Wataru , Hirota Sumire , Goto Aya , Ohira Tetsuya , Yasumura Seiji , Tanigawa Koichi
Published: January 2018

After the Fukushima Daiichi Nuclear Power Station accident in 2011, concerns about radiation exposure and decline in subjective well-being have been reported. To tackle these problems, various countermeasures in relation to radiation have been implemented. In this study, we comprehensively evaluated the effects of radiological countermeasures on subjective well-being (e.g., satisfaction with life (SWL) and emotional well-being) and radiation anxiety, through a questionnaire survey targeting Fukushima residents (N = 1023). Propensity scores matching was applied to evaluate significant effects of radiological countermeasures on subjective well-being and radiation anxiety. Among the radiological countermeasures, thyroid examination, whole body counter, and air dose monitoring showed the highest proportions of participation, utilization, and useful evaluation, suggesting a high degree of public attention focused on these countermeasures. The basic survey was associated with significant increases in SWL and self-rated health (SH). Thyroid examination was significantly associated with not only a reduction in radiation anxiety but also an increase of emotional stress, suggesting the importance of careful design of system and detailed communication. Food inspection was associated with deterioration in SH. Those who utilized explanatory meetings showed increases in sadness, worry, and radiation anxiety, indicating that additional attention is required of the experts and authorities involved in explanatory meetings.
The Safety of the Neighborhood Environment and Physical Activity in Czech and Polish Adolescents
Authors: Mitáš Josef , Sas-Nowosielski Krzysztof , Groffik Dorota , Frömel Karel
Published: January 2018

(1) Background: An increase in or at least the sustainment of walking activities across a wide section of the population is a crucial health-related task for Central and East European countries. The aim of this study was to assess the associations between adolescents’ walking activities and various levels of perceived safety of the built environment in differing socio-demographic backgrounds of Poland and the Czech Republic. Furthermore, we aimed to determine major moderators affecting the walking habits of adolescents in areas with different levels of walkability. (2) Methods: The surveys were conducted during the 2008–2009 and 2013–2014 school years in 24 Polish and 35 Czech secondary schools, with a sample of 2001 adolescents. All participants completed the International Physical Activity Questionnaire–Long Form and the NEWS–Abbreviated. Selected students took part in objective weekly monitoring of physical activity (PA). (3) Results: Boys and girls who perceived their neighborhood environment as the safest were significantly more likely to meet the recommendations for leisure-time walking. Adolescents from the safest environment achieved 11,024 steps/day on average, while those from the least safe environment achieved 9686 steps/day. (4) Conclusions: A safe neighborhood environment significantly predicts walking activities among girls. Environmental safety improvement can support the active transport and better use of leisure time PA.
Trypsin Binding with Copper Ions Scavenges Superoxide: Molecular Dynamics-Based Mechanism Investigation
Authors: Li Xin , Zhong Yongliang , Zhao Chunyan
Published: January 2018

Trypsin is a serine protease, which has been proved to be a novel superoxide scavenger. The burst of superoxide induced by polychlorinated biphenyls can be impeded by trypsin in both wild type and sod knockout mutants of Escherichia coli. The experimental results demonstrated that the activities of superoxide scavenging of trypsin were significantly accelerated by Cu ions. Also, with the addition of Cu ions, a new β-sheet (β7) transited from a random coil in the Cu(II)-trypsin (TP) system, which was favorable for the formation of more contacts with other sheets of trypsin. Residue–residue network analysis and the porcupine plots proved that the Cu ion in trypsin strengthened some native interactions among residues, which ultimately resulted in much greater stability of the Cu(II)-TP system. Moreover, compact and stable trypsin structures with Cu ions might be responsible for significantly provoking the activity of superoxide scavenging.
Spatial Analysis of Clustering of Foreclosures in the Poorest-Quality Housing Urban Areas: Evidence from Catalan Cities
Authors: Gutiérrez Aaron , Arauzo-Carod Josep-Maria
Published: January 2018

This paper uses data on housing stock owned by financial entities as a result of foreclosures to analyze (1) the spatial logic of Spain’s mortgage crisis in urban areas, and (2) the characteristics of the types of housing most affected by this phenomenon. Nearest-Neighbor Index and Ripley’s K function analyses were applied in two Catalan cities (Tarragona and Terrassa). The results obtained show that foreclosures tend to be concentrated in the most deprived neighborhoods. The general pattern of clustering also tends to be most intense for smaller and cheaper housing. Our findings show that home foreclosures have been concentrated in only a few neighborhoods and precisely in those containing the poorest-quality housing stock. They also provide new evidence of the characteristics and spatial patterns of the housing stock accumulated by banks in Catalonia as a result of the recent wave of evictions associated with foreclosures.
Detecting Anomalous Trajectories and Behavior Patterns Using Hierarchical Clustering from Taxi GPS Data
Authors: Wang Yulong , Qin Kun , Chen Yixiang , Zhao Pengxiang
Published: January 2018

Anomalous taxi trajectories are those chosen by a small number of drivers that are different from the regular choices of other drivers. These anomalous driving trajectories provide us an opportunity to extract driver or passenger behaviors and monitor adverse urban traffic events. Because various trajectory clustering methods have previously proven to be an effective means to analyze similarities and anomalies within taxi GPS trajectory data, we focus on the problem of detecting anomalous taxi trajectories, and we develop our trajectory clustering method based on the edit distance and hierarchical clustering. To achieve this objective, first, we obtain all the taxi trajectories crossing the same source–destination pairs from taxi trajectories and take these trajectories as clustering objects. Second, an edit distance algorithm is modified to measure the similarity of the trajectories. Then, we distinguish regular trajectories and anomalous trajectories by applying adaptive hierarchical clustering based on an optimal number of clusters. Moreover, we further analyze these anomalous trajectories and discover four anomalous behavior patterns to speculate on the cause of an anomaly based on statistical indicators of time and length. The experimental results show that the proposed method can effectively detect anomalous trajectories and can be used to infer clearly fraudulent driving routes and the occurrence of adverse traffic events.
Role of Aquaporins in Determining Carbon and Nitrogen Status in Higher Plants
Authors: Gao Limin , Lu Zhifeng , Ding Lei , Guo Junjie , Wang Min , Ling Ning , Guo Shiwei , Shen Qirong
Published: January 2018

Aquaporins (AQPs) are integral membrane proteins facilitating the transport of water and some small neutral molecules across cell membranes. In past years, much effort has been made to reveal the location of AQPs as well as their function in water transport, photosynthetic processes, and stress responses in higher plants. In the present review, we paid attention to the character of AQPs in determining carbon and nitrogen status. The role of AQPs during photosynthesis is characterized as its function in transporting water and CO2 across the membrane of chloroplast and thylakoid; recalculated results from published studies showed that over-expression of AQPs contributed to 25% and 50% increases in stomatal conductance (gs) and mesophyll conductance (gm), respectively. The nitrogen status in plants is regulated by AQPs through their effect on water flow as well as urea and NH4+ uptake, and the potential role of AQPs in alleviating ammonium toxicity is discussed. At the same time, root and/or shoot AQP expression is quite dependent on both N supply amounts and forms. Future research directions concerning the function of AQPs in regulating plant carbon and nitrogen status as well as C/N balance are also highlighted.
Effects of Acanthopanax senticosus on Brain Injury Induced by Simulated Spatial Radiation in Mouse Model Based on Pharmacokinetics and Comparative Proteomics
Authors: Zhou Yingyu , Cheng Cuilin , Baranenko Denis , Wang Jiaping , Li Yongzhi , Lu Weihong
Published: January 2018

The active compounds in Acanthopanax senticosus (AS) have different pharmacokinetic characteristics in mouse models. Cmax and AUC of Acanthopanax senticosus polysaccharides (ASPS) were significantly reduced in radiation-injured mice, suggesting that the blood flow of mouse was blocked or slowed, due to the pathological state of ischemia and hypoxia, which are caused by radiation. In contrast, the ability of various metabolizing enzymes to inactivate, capacity of biofilm transport decrease, and lessening of renal blood flow accounts for radiation, resulting in the accumulation of syringin and eleutheroside E in the irradiated mouse. Therefore, there were higher pharmacokinetic parameters—AUC, MRT, and t1/2 of the two compounds in radiation-injured mouse, when compared with normal mouse. In order to investigate the intrinsic mechanism of AS on radiation injury, AS extract’s protective effects on brain, the main part of mouse that suffered from radiation, were explored. The function of AS extract in repressing expression changes of radiation response proteins in prefrontal cortex (PFC) of mouse brain included tubulin protein family (α-, β-tubulin subunits), dihydropyrimidinase-related protein 2 (CRMP2), γ-actin, 14-3-3 protein family (14-3-3ζ, ε), heat shock protein 90β (HSP90β), and enolase 2. The results demonstrated the AS extract had positive effects on nerve cells’ structure, adhesion, locomotion, fission, and phagocytosis, through regulating various action pathways, such as Hippo, phagosome, PI3K/Akt (phosphatidylinositol 3 kinase/protein kinase B), Neurotrophin, Rap1 (Ras-related protein RAP-1A), gap junction glycolysis/gluconeogenesis, and HIF-1 (Hypoxia-inducible factor 1) signaling pathways to maintain normal mouse neurological activity. All of the results indicated that AS may be a promising alternative medicine for the treatment of radiation injury in mouse brain. It would be tested that whether the bioactive ingredients of AS could be effective through the blood–brain barrier in the future.
Personalized Antidepressant Selection and Pathway to Novel Treatments: Clinical Utility of Targeting Inflammation
Authors: Jha Manish , Trivedi Madhukar
Published: January 2018

Major depressive disorder (MDD) is a chronic condition that affects one in six adults in the US during their lifetime. The current practice of antidepressant medication prescription is a trial-and-error process. Additionally, over a third of patients with MDD fail to respond to two or more antidepressant treatments. There are no valid clinical markers to personalize currently available antidepressant medications, all of which have similar mechanisms targeting monoamine neurotransmission. The goal of this review is to summarize the recent findings of immune dysfunction in patients with MDD, the utility of inflammatory markers to personalize treatment selection, and the potential of targeting inflammation to develop novel antidepressant treatments. To personalize antidepressant prescription, a c-reactive protein (CRP)-matched treatment assignment can be rapidly implemented in clinical practice with point-of-care fingerstick tests. With this approach, 4.5 patients need to be treated for 1 additional remission as compared to a CRP-mismatched treatment assignment. Anti-cytokine treatments may be effective as novel antidepressants. Monoclonal antibodies against proinflammatory cytokines, such as interleukin 6, interleukin 17, and tumor necrosis factor α, have demonstrated antidepressant effects in patients with chronic inflammatory conditions who report significant depressive symptoms. Additional novel antidepressant strategies targeting inflammation include pharmaceutical agents that block the effect of systemic inflammation on the central nervous system. In conclusion, inflammatory markers offer the potential not only to personalize antidepressant prescription but also to guide the development of novel mechanistically-guided antidepressant treatments.
Anesthetic Preconditioning as Endogenous Neuroprotection in Glaucoma
Authors: Chou Tsung-Han , Musada Ganeswara , Romano Giovanni , Bolton Elizabeth , Porciatti Vittorio
Published: January 2018

Blindness in glaucoma is the result of death of Retinal Ganglion Cells (RGCs) and their axons. RGC death is generally preceded by a stage of reversible dysfunction and structural remodeling. Current treatments aimed at reducing intraocular pressure (IOP) are ineffective or incompletely effective in management of the disease. IOP-independent neuroprotection or neuroprotection as adjuvant to IOP lowering in glaucoma remains a challenge as effective agents without side effects have not been identified yet. We show in DBA/2J mice with spontaneous IOP elevation and glaucoma that the lifespan of functional RGCs can be extended by preconditioning RGCs with retrobulbar lidocaine in one eye at four months of age that temporary blocks RGC axonal transport. The contralateral, PBS-injected eye served as control. Lidocaine-induced impairment of axonal transport to superior colliculi was assessed by intravitreal injection of cholera toxin B. Long-term (nine months) effect of lidocaine were assessed on RGC electrical responsiveness (PERG), IOP, expression of relevant protein (BDNF, TrkB, PSD95, GFAP, Synaptophysin, and GAPDH) and RGC density. While lidocaine treatment did not alter the age-related increase of IOP, TrkB expression was elevated, GFAP expression was decreased, RGC survival was improved by 35%, and PERG function was preserved. Results suggest that the lifespan of functional RGCs in mouse glaucoma can be extended by preconditioning RGCs in early stages of the disease using a minimally invasive treatment with retrobulbar lidocaine, a common ophthalmologic procedure. Lidocaine is inexpensive, safe and is approved by Food and Drug Administration (FDA) to be administered intravenously.
Hypoxia and Hormone-Mediated Pathways Converge at the Histone Demethylase KDM4B in Cancer
Authors: Yang Jun , Harris Adrian , Davidoff Andrew
Published: January 2018

Hormones play an important role in pathophysiology. The hormone receptors, such as estrogen receptor alpha and androgen receptor in breast cancer and prostate cancer, are critical to cancer cell proliferation and tumor growth. In this review we focused on the cross-talk between hormone and hypoxia pathways, particularly in breast cancer. We delineated a novel signaling pathway from estrogen receptor to hypoxia-inducible factor 1, and discussed the role of this pathway in endocrine therapy resistance. Further, we discussed the estrogen and hypoxia pathways converging at histone demethylase KDM4B, an important epigenetic modifier in cancer.
Improvement of Verticillium Wilt Resistance by Applying Arbuscular Mycorrhizal Fungi to a Cotton Variety with High Symbiotic Efficiency under Field Conditions
Authors: Zhang Qiang , Gao Xinpeng , Ren Yanyun , Ding Xinhua , Qiu Jiajia , Li Ning , Zeng Fanchang , Chu Zhaohui
Published: January 2018

Arbuscular mycorrhizal fungi (AMF) play an important role in nutrient cycling processes and plant stress resistance. To evaluate the effect of Rhizophagus irregularis CD1 on plant growth promotion (PGP) and Verticillium wilt disease, the symbiotic efficiency of AMF (SEA) was first investigated over a range of 3% to 94% in 17 cotton varieties. The high-SEA subgroup had significant PGP effects in a greenhouse. From these results, the highest-SEA variety of Lumian 1 was selected for a two-year field assay. Consistent with the performance from the greenhouse, the AMF-mediated PGP of Lumian 1 also produced significant results, including an increased plant height, stem diameter, number of petioles, and phosphorus content. Compared with the mock treatment, AMF colonization obviously inhibited the symptom development of Verticillium dahliae and more strongly elevated the expression of pathogenesis-related genes and lignin synthesis-related genes. These results suggest that AMF colonization could lead to the mycorrhiza-induced resistance (MIR) of Lumian 1 to V. dahliae. Interestingly, our results indicated that the AMF endosymbiont could directly inhibit the growth of phytopathogenic fungi including V. dahliae by releasing undefined volatiles. In summary, our results suggest that stronger effects of AMF application result from the high-SEA.
Omega-3 Polyunsaturated Fatty Acids Time-Dependently Reduce Cell Viability and Oncogenic MicroRNA-21 Expression in Estrogen Receptor-Positive Breast Cancer Cells (MCF-7)
Authors: LeMay-Nedjelski Lauren , Mason-Ennis Julie , Taibi Amel , Comelli Elena , Thompson Lilian
Published: January 2018

The omega-3 polyunsaturated fatty acid (n-3 PUFA), α-linolenic acid (ALA), and its metabolites, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), independently reduce the growth of breast cancer cells in vitro, but the mechanisms, which may involve microRNA (miRNA), are still unclear. The expression of the oncomiR, miR-21, is reduced by DHA treatment, but the effects of ALA on miR-21, alone or combined with EPA and DHA under physiologically relevant concentrations, have not been investigated. The effects of ALA alone and +/−EPA and DHA at the blood molar ratios seen in either humans (1.0:1.0:2.5, ALA:EPA:DHA) or mice (1.0:0.4:3.1, ALA:EPA:DHA) post flaxseed oil consumption (containing ALA) were assessed in vitro in MCF-7 breast cancer cells. Cell viability and the expression of miR-21 and its molecular target, phosphatase and tension homolog (PTEN, gene and protein), at different time points, were examined. At 1, 3, 48 and 96 h ALA alone and 24 h animal ratio treatments significantly reduced MCF-7 cell viability, while 1 and 3 h ALA alone and human and animal ratio treatments all significantly reduced miR-21 expression, and 24 h animal ratio treatment reduced miR-21 expression; these effects were not associated with changes in PTEN gene or protein expressions. We showed for the first time that ALA alone or combined with EPA and DHA at levels seen in human and animal blood post-ALA consumption can significantly reduce cell viability and modulate miR-21 expression in a time- and concentration-dependent manner, with the animal ratio containing higher DHA having a greater effect. The time dependency of miR-21 effects suggests the significance of considering time as a variable in miRNA studies, particularly of miR-21.
Transcriptome Analysis Based on RNA-Seq in Understanding Pathogenic Mechanisms of Diseases and the Immune System of Fish: A Comprehensive Review
Authors: Sudhagar Arun , Kumar Gokhlesh , El-Matbouli Mansour
Published: January 2018

In recent years, with the advent of next-generation sequencing along with the development of various bioinformatics tools, RNA sequencing (RNA-Seq)-based transcriptome analysis has become much more affordable in the field of biological research. This technique has even opened up avenues to explore the transcriptome of non-model organisms for which a reference genome is not available. This has made fish health researchers march towards this technology to understand pathogenic processes and immune reactions in fish during the event of infection. Recent studies using this technology have altered and updated the previous understanding of many diseases in fish. RNA-Seq has been employed in the understanding of fish pathogens like bacteria, virus, parasites, and oomycetes. Also, it has been helpful in unraveling the immune mechanisms in fish. Additionally, RNA-Seq technology has made its way for future works, such as genetic linkage mapping, quantitative trait analysis, disease-resistant strain or broodstock selection, and the development of effective vaccines and therapies. Until now, there are no reviews that comprehensively summarize the studies which made use of RNA-Seq to explore the mechanisms of infection of pathogens and the defense strategies of fish hosts. This review aims to summarize the contemporary understanding and findings with regard to infectious pathogens and the immune system of fish that have been achieved through RNA-Seq technology.
Abnormal Sphingolipid World in Inflammation Specific for Lysosomal Storage Diseases and Skin Disorders
Authors: Moskot Marta , Bocheńska Katarzyna , Jakóbkiewicz-Banecka Joanna , Banecki Bogdan , Gabig-Cimińska Magdalena
Published: January 2018

Research in recent years has shown that sphingolipids are essential signalling molecules for the proper biological and structural functioning of cells. Long-term studies on the metabolism of sphingolipids have provided evidence for their role in the pathogenesis of a number of diseases. As many inflammatory diseases, such as lysosomal storage disorders and some dermatologic diseases, including psoriasis, atopic dermatitis and ichthyoses, are associated with the altered composition and metabolism of sphingolipids, more studies precisely determining the responsibilities of these compounds for disease states are required to develop novel pharmacological treatment opportunities. It is worth emphasizing that knowledge from the study of inflammatory metabolic diseases and especially the possibility of their treatment may lead to insight into related metabolic pathways, including those involved in the formation of the epidermal barrier and providing new approaches towards workable therapies.
Can EGCG Alleviate Symptoms of Down Syndrome by Altering Proteolytic Activity?
Authors: Wyganowska-Świątkowska Marzena , Matthews-Kozanecka Maja , Matthews-Brzozowska Teresa , Skrzypczak-Jankun Ewa , Jankun Jerzy
Published: January 2018

Down syndrome (DS), also known as “trisomy 21”, is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. Silencing these extra genes is beyond existing technology and seems to be impractical. A number of pharmacologic options have been proposed to change the quality of life and lifespan of individuals with DS. It was reported that treatment with epigallocatechin gallate (EGCG) improves cognitive performance in animal models and in humans, suggesting that EGCG may alleviate symptoms of DS. Traditionally, EGCG has been associated with the ability to reduce dual specificity tyrosine phosphorylation regulated kinase 1A activity, which is overexpressed in trisomy 21. Based on the data available in the literature, we propose an additional way in which EGCG might affect trisomy 21—namely by modifying the proteolytic activity of the enzymes involved. It is known that, in Down syndrome, the nerve growth factor (NGF) metabolic pathway is altered: first by downregulating tissue plasminogen activator (tPA) that activates plasminogen to plasmin, an enzyme converting proNGF to mature NGF; secondly, overexpression of metalloproteinase 9 (MMP-9) further degrades NGF, lowering the amount of mature NGF. EGCG inhibits MMP-9, thus protecting NGF. Urokinase (uPA) and tPA are activators of plasminogen, and uPA is inhibited by EGCG, but regardless of their structural similarity tPA is not inhibited. In this review, we describe mechanisms of proteolytic enzymes (MMP-9 and plasminogen activation system), their role in Down syndrome, their inhibition by EGCG, possible degradation of this polyphenol and the ability of EGCG and its degradation products to cross the blood–brain barrier. We conclude that known data accumulated so far provide promising evidence of MMP-9 inhibition by EGCG in the brain, which could slow down the abnormal degradation of NGF.
Functional Analyses of RUNX3 and CaMKIINα in Ovarian Cancer Cell Lines Reveal Tumor-Suppressive Functions for CaMKIINα and Dichotomous Roles for RUNX3 Transcript Variants
Authors: Heinze Karolin , Kritsch Daniel , Mosig Alexander , Dürst Matthias , Häfner Norman , Runnebaum Ingo
Published: January 2018

(1) Background: Epithelial ovarian cancer (EOC) is the most lethal cancer of the female reproductive system. In an earlier study, we identified multiple genes as hypermethylated in tumors of patients with poor prognosis. The most promising combination of markers to predict a patient’s outcome was CaMKIINα and RUNX3. Aim of this study was to functionally validate the importance of both genes. (2) Methods: IC50 measurements, cell cycle distribution-, proliferation, and migration experiments were conducted after transgene overexpression in two EOC cell lines. (3) Results: We showed that CaMKIINα has tumor suppressive functions in vitro and reduces proliferation, migration, and colony formation. However, it had no effect on the reversion of the resistance to cisplatin. RUNX3 exhibited dualistic functions related to cisplatin sensitivity and migration capacity, depending on the respective transcript variant (TV). A2780 cells expressing RUNX3 TV2—the promoter of which harbors a CpG (5′-C-phosphate-G-3′) island and is potentially inactivated by hypermethylation—exhibited increased cisplatin sensitivity and reduced migration properties. However, RUNX3 TV1, not affected by CpG island methylation could be characterized as mediating resistance and enhancing migration in A2780. The higher resistance of RUNX3 TV1 transfected cells correlates with a reduction of cell proliferation. Moreover, RUNX3 TV1 expressing cells exhibit a reduced cell cycle arrest at the gap-2 or mitosis phase (G2/M) under cisplatin treatment comparable to resistant A2780 subcultures. (4) Conclusion: It appears that CaMKIINα and RUNX3 TV2 can reduce the malignant potential of EOC cells.
Acknowledgement to Reviewers of the International Journal of Turbomachinery, Propulsion and Power in 2017
Authors:   International Journal of Turbomachinery, Propulsion and Power Editorial Office
Published: January 2018

Peer review is an essential part in the publication process, ensuring that the International Journal of Turbomachinery, Propulsion and Power maintains high quality standards for its published papers.[...]
Improving Particle Swarm Optimization Based on Neighborhood and Historical Memory for Training Multi-Layer Perceptron
Authors: Li Wei
Published: January 2018

Many optimization problems can be found in scientific and engineering fields. It is a challenge for researchers to design efficient algorithms to solve these optimization problems. The Particle swarm optimization (PSO) algorithm, which is inspired by the social behavior of bird flocks, is a global stochastic method. However, a monotonic and static learning model, which is applied for all particles, limits the exploration ability of PSO. To overcome the shortcomings, we propose an improving particle swarm optimization algorithm based on neighborhood and historical memory (PSONHM). In the proposed algorithm, every particle takes into account the experience of its neighbors and its competitors when updating its position. The crossover operation is employed to enhance the diversity of the population. Furthermore, a historical memory Mw is used to generate new inertia weight with a parameter adaptation mechanism. To verify the effectiveness of the proposed algorithm, experiments are conducted with CEC2014 test problems on 30 dimensions. Finally, two classification problems are employed to investigate the efficiencies of PSONHM in training Multi-Layer Perceptron (MLP). The experimental results indicate that the proposed PSONHM can effectively solve the global optimization problems.
A Hybrid Approach to Recognising Activities of Daily Living from Object Use in the Home Environment
Authors: Ihianle Isibor , Naeem Usman , Islam Syed , Tawil Abdel-Rahman
Published: January 2018

Accurate recognition of Activities of Daily Living (ADL) plays an important role in providing assistance and support to the elderly and cognitively impaired. Current knowledge-driven and ontology-based techniques model object concepts from assumptions and everyday common knowledge of object use for routine activities. Modelling activities from such information can lead to incorrect recognition of particular routine activities resulting in possible failure to detect abnormal activity trends. In cases where such prior knowledge are not available, such techniques become virtually unemployable. A significant step in the recognition of activities is the accurate discovery of the object usage for specific routine activities. This paper presents a hybrid framework for automatic consumption of sensor data and associating object usage to routine activities using Latent Dirichlet Allocation (LDA) topic modelling. This process enables the recognition of simple activities of daily living from object usage and interactions in the home environment. The evaluation of the proposed framework on the Kasteren and Ordonez datasets show that it yields better results compared to existing techniques.
Material Structural Deficiencies of Road Bridges in the U.S.
Authors: Farhey Daniel
Published: January 2018

This study analyzes the National Bridge Inventory in the U.S. to determine the relative structural deficiencies of bridge materials, comparing between the overall national values and each state, geographically. The analysis considers the most common bridge construction materials—concrete, steel, and prestressed/post-tensioned concrete. The results suggest need to reassess the efficacy of best performance practices for steel bridges and for states with structural deficiencies above the national average. Geographic consistency of structurally deficient bridge density with population density shows need to improve intervention strategies for regions with higher levels of service usage. The study also compares the relative operational lifespan of bridge materials in each state. The average structurally deficient bridge ages are lower than the 75-year life-cycle expectancy. Prestressed/post-tensioned concrete bridges reveal relatively lower lifespan. Over time, concrete and steel bridges show some gradual improvement with decreasing percentage of structural deficiency and increasing lifespan. Prestressed/post-tensioned concrete bridges reveal shifting earlier accumulation of structural deficiency for a particular age group. The study also reveals relative climate effects. Climate conditions correlate differently with the structural deficiency and life cycle of bridge materials in each state. Structurally deficient bridge densities show correlation with climate maps, especially under colder and moist conditions.
Interface Enthalpy-Entropy Competition in Nanoscale Metal Hydrides
Authors: Patelli Nicola , Calizzi Marco , Pasquini Luca
Published: January 2018

We analyzed the effect of the interfacial free energy on the thermodynamics of hydrogen sorption in nano-scaled materials. When the enthalpy and entropy terms are the same for all interfaces, as in an isotropic bi-phasic system, one obtains a compensation temperature, which does not depend on the system size nor on the relative phase abundance. The situation is different and more complex in a system with three or more phases, where the interfaces have different enthalpy and entropy. We also consider the possible effect of elastic strains on the stability of the hydride phase and on hysteresis. We compare a simple model with experimental data obtained on two different systems: (1) bi-phasic nanocomposites where ultrafine TiH2 crystallite are dispersed within a Mg nanoparticle and (2) Mg nanodots encapsulated by different phases.
Acknowledgement to Reviewers of Instruments in 2017
Authors:   Instruments Editorial Office
Published: January 2018

Peer review is an essential part in the publication process, ensuring that Instruments maintains high quality standards for its published papers [...]
Calcium Phosphates as Delivery Systems for Bisphosphonates
Authors: Bigi Adriana , Boanini Elisa
Published: January 2018

Bisphosphonates (BPs) are the most utilized drugs for the treatment of osteoporosis, and are usefully employed also for other pathologies characterized by abnormally high bone resorption, including bone metastases. Due to the great affinity of these drugs for calcium ions, calcium phosphates are ideal delivery systems for local administration of BPs to bone, which is aimed to avoid/limit the undesirable side effects of their prolonged systemic use. Direct synthesis in aqueous medium and chemisorptions from solution are the two main routes proposed to synthesize BP functionalized calcium phosphates. The present review overviews the information acquired through the studies on the interaction between bisphosphonate molecules and calcium phosphates. Moreover, particular attention is addressed to some important recent achievements on the applications of BP functionalized calcium phosphates as biomaterials for bone substitution/repair.
Methods to Improve Osseointegration of Dental Implants in Low Quality (Type-IV) Bone: An Overview
Authors: Alghamdi Hamdan
Published: January 2018

Nowadays, dental implants have become more common treatment for replacing missing teeth and aim to improve chewing efficiency, physical health, and esthetics. The favorable clinical performance of dental implants has been attributed to their firm osseointegration, as introduced by Brånemark in 1965. Although the survival rate of dental implants over a 10-year observation has been reported to be higher than 90% in totally edentulous jaws, the clinical outcome of implant treatment is challenged in compromised (bone) conditions, as are frequently present in elderly people. The biomechanical characteristics of bone in aged patients do not offer proper stability to implants, being similar to type-IV bone (Lekholm & Zarb classification), in which a decreased clinical fixation of implants has been clearly demonstrated. However, the search for improved osseointegration has continued forward for the new evolution of modern dental implants. This represents a continuum of developments spanning more than 20 years of research on implant related-factors including surgical techniques, implant design, and surface properties. The methods to enhance osseointegration of dental implants in low quality (type-IV) bone are described in a general manner in this review.
Error Separation Method for Precision Measurement of the Run-Out of a Microdrill Bit by Using a Laser Scan Micrometer Measurement System
Authors: Niu Zengyuan , Chen Yuan-Liu , Shimizu Yuki , Matsukuma Hiraku , Gao Wei
Published: January 2018

This paper describes an error separation method for a precision measurement of the run-out of a microdrill bit by using a measurement system consisting of a concentricity gauge and a laser scan micrometer (LSM). The proposed error separation method can achieve a sub-micrometric measurement accuracy of the run-out of the microdrill bit without the requirement of ultra-precision rotary drive devices. In the measurement, the spindle error motion of the concentricity gauge is firstly measured by using the LSM and a small-diameter artifact, instead of the conventionally used displacement probes and large-diameter artifact, in order to determine the fine position of the concentricity gauge when the spindle error motion is at its minimum. The microdrill bit is rotated at the fine position for the measurement of the run-out, so that the influence of the spindle error motion can thus be reduced, which could not be previously realized by commercial measurement systems. Experiments were carried out to verify the feasibility of the proposed error separation method for the measurement of the run-out of the microdrill bit. The measurement results and the measurement uncertainty confirmed that the proposed method is reliable for the run-out measurement with sub-micrometric accuracy.
Integrated System Design for a Large Wind Turbine Supported on a Moored Semi-Submersible Platform
Authors: Liu Jinsong , Thomas Edwin , Manuel Lance , Griffith D. , Ruehl Kelley , Barone Matthew
Published: January 2018

Over the past few decades, wind energy has emerged as an alternative to conventional power generation that is economical, environmentally friendly and, importantly, renewable. Specifically, offshore wind energy is being considered by a number of countries to harness the stronger and more consistent wind resource compared to that over land. To meet the projected “20% energy from wind by 2030” scenario that was announced in 2006, 54 GW of added wind energy capacity need to come from offshore according to a National Renewable Energy Laboratory (NREL) study. In this study, we discuss the development of a semi-submersible floating offshore platform with a catenary mooring system to support a very large 13.2-MW wind turbine with 100-m blades. An iterative design process is applied to baseline models with Froude scaling in order to achieve preliminary static stability. Structural dynamic analyses are performed to investigate the performance of the new model using a finite element method approach for the tower and a boundary integral equation (panel) method for the platform. The steady-state response of the system under uniform wind and regular waves is first studied to evaluate the performance of the integrated system. Response amplitude operators (RAOs) are computed in the time domain using white-noise wave excitation; this serves to highlight nonlinear, as well as dynamic characteristics of the system. Finally, selected design load cases (DLCs) and the stochastic dynamic response of the system are studied to assess the global performance for sea states defined by wind fields with turbulence and long-crested irregular waves.
Modified Stieltjes Transform and Generalized Convolutions of Probability Distributions
Authors: Klebanov Lev , Roozegar Rasool
Published: January 2018

The classical Stieltjes transform is modified in such a way as to generalize both Stieltjes and Fourier transforms. This transform allows the introduction of new classes of commutative and non-commutative generalized convolutions. A particular case of such a convolution for degenerate distributions appears to be the Wigner semicircle distribution.
Acknowledgement to Reviewers of Journal of Sensor and Actuator Networks in 2017
Authors:   Journal of Sensor and Actuator Networks Editorial Office
Published: January 2018

Peer review is an essential part in the publication process, ensuring that Journal of Sensor and Actuator Networks maintains high quality standards for its published papers.[...]
Acknowledgement to Reviewers of Land in 2017
Authors:   Land Editorial Office
Published: January 2018

Peer review is an essential part in the publication process, ensuring that Land maintains high quality standards for its published papers. In 2017, a total of 88 papers were published in the journal.[...]