bluuebunny/crossref_metadata_2025 huggingface dataset:
A CASE OF STURGE-WEBER SYNDROME
Authors:   Neurology Department, „Colentina“ Clinical Hospital, Bucharest, Trasca Daniela , Stefanescu Vlad Claudiu ,   Neurology Department, „Colentina“ Clinical Hospital, Bucharest, Cojocaru Inimioara Mihaela ,   Neurology Department, „Colentina“ Clinical Hospital, Bucharest,   „Carol Davila“ University of Medicine and Pharmacy, Bucharest
Published: September 2021

Encephalo-trigeminal angiomatosis of Sturge-Weber-Krabbe-Dimitri is a rare hereditary sporadic facomatosis, characterized by the presence of angiomatosis of brain lining vessels, face and eye capillaries. We present the case of a 25-year old girl with a birth mark, an facial angioma localized in the territory of the right ophthalmic nerve, also since she had 4 months, she presents generalized tonic-clonic seizures, for which she is currently under treatment with Levetiracetam 1000 mg/day, Lamotrigine 100 mg/day, Valproic Acid 1500 mg/day and Clonazepam 2 mg/day. She was hospitalized because of the higher incidence of the seizures, despite the treatment that she performs. Physical examination revealed her facial angioma, a facial dysmorphism, gingival hypertrophy with sharp teeth, and she has an upper limb asymmetrical development. The neurological exam reveals central facial paresis, a rough motor deficit on her left side, increased tendon reflexes on the left side, left limb ataxia, and a minor cognitive disorder. The cerebral CT identified cortical asymmetry with right frontal atrophy, gyriform calcifications and frontal hyperostosis. The brain MRI showed hemihypotrophia of the right cerebral hemisphere, especially regarding the frontal lobe, gyriform calcifications on the right side, hypertrophy of the right frontal sinus. We increased the dosage of antiepileptic drugs, to 1500 mg/day of Levetiracetam and 200 mg/day of Lamotrigine. The outcome was favorable, the patient was seizures-free. The particularity of the case is that being a rare disease, it is easily overlooked, although the patient had classic symptoms and imagistic findings for Sturge-Weber-Krabbe disease.
A STROKE OF NEGLIGENCE
Authors:   Neurology Department of the „Colentina“ Clinical Hospital, Bucharest, Trasca Daniela , Stefanescu Vlad Claudiu ,   Neurology Department of the „Colentina“ Clinical Hospital, Bucharest, Cojocaru Inimioara Mihaela ,   Neurology Department of the „Colentina“ Clinical Hospital, Bucharest,   „Carol Davila“ University of Medicine and Pharmacy, Bucharest
Published: September 2021

A 81-year-old female patient suffering from type II diabetes mellitus, atrial fibrillation, hypertension and who neglected taking any medication at home, was referred to our clinic from the "St. Pantelimon" Hospital, where she had been brought by her family one day earlier, because of severely altered state of consciousness. Upon examination she was comatose – 3 pts. on the Glasgow Coma Scale (E1V1M1), had midriatic pupils, was tetraplegic and had abolished reflexes.
PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMAS
Authors:   Department of Neurology, Fundeni Clinical Institute, „Carol Davila“ University of Medicine and Pharmacy, Bucharest, Dulamea Adriana Octaviana
Published: September 2021

Primary central nervous system lymphoma (PCNSL) is an aggressive non-Hodgkin B-cell lymphoma with characteristic clinical behavior, biological features and poor prognosis despite complex treatment. PCNSL has a median survival of 17 to 45 months in immunocompetent patients, and only 20-30% of cases can be cured successfully. Clinical outcome has improved since the advances in combination chemotherapy protocols, addition of whole brain radiation therapy, encouraging responses of rituximab administration in refractory PCNSL and autologous hematopoietic stem-cell transplantation as consolidative therapy. The author review the recent data on pathogenesis, diagnostic methods and treatment strategies of PCNSL in immunocompetent patients.
CORRELATION BETWEEN MIGRAINE SEVERITY AND COMORBIDITIES IN EPISODIC MIGRAINE PATIENTS
Authors:   Neurology Department, Clinical Rehabilitation Hospital, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Bulboaca Adriana , Ursu Corina ,   Neurology Department, Clinical Rehabilitation Hospital, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Uifalean Ana ,   Neurology Department, Clinical Rehabilitation Hospital, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Bulboaca Angelo ,   Neurology Department, Clinical Rehabilitation Hospital, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca
Published: September 2021

Introduction. Migraine is an important cause of disability that affects the quality of life producing a substantial social impairment. Objectives. The aim of this study was to evaluate the correlation between migraine severity and comorbidities in patients with episodic migraine. Methods. 2 groups of patients were included in the study: group 1 – control group (healthy subjects, n = 50), and group 2 – study group (patients with episodic migraine attacks, n = 65). Both groups were assessed for nonmodifiable risk factors (age), and modifiable risk factors: BMI (body mass index), lipids profiles (LDL-cholesterol, HDL-cholesterol, triglycerides), inflammatory parameters (C reactive protein and fibrinogen), and endothelial dysfunction (nitric oxide synthesis expressed as NOx). The migraine was diagnosed according to ICHD-2 (International Classification of Headache Disorders) and the severity was evaluated by MIDAS (Migraine Disability Assessment Scale). The study group was compared with control group. The parameters that showed statistic significance were correlated with MIDAS scale. Results. There was a significant correlation between the severity and frequency of migraine attacks (evaluated by MIDAS scale) and BMI. The subgroup with higher inflammatory parameters and decreased NOx had an increased MIDAS score. Conclusions. The connection between obesity, inflammatory parameters and migraine may be useful for new prophylaxis potent therapies. The individual personalized therapies according with particular risk factors of each patient may be a chance for better results. Identification and control of risk factors in migraine patients may be particularly important.
DYSPLASTIC WHITE MATTER LESIONS IN PATIENT WITH NEUROFIBROMATOSIS 1
Authors:   Department of Endocrinology, Narayana Medical College Hospital, Chinthareddypalem, Nellore, Andhra Pradesh (India), Reddy P. Amaresh , Agrawal Amit ,   Department of Neurosurgery, Narayana Medical College Hospital, Chinthareddypalem, Nellore, Andhra Pradesh (India), Reddy V. Umamaheshwar ,   Department of Radiology, Narayana Medical College Hospital, Chinthareddypalem, Nellore, Andhra Pradesh (India), Radharani P. ,   Department of Endocrinology, Narayana Medical College Hospital, Chinthareddypalem, Nellore, Andhra Pradesh (India), Reddy Sahith ,   Department of Radiology, Narayana Medical College Hospital, Chinthareddypalem, Nellore, Andhra Pradesh (India)
Published: September 2021

Dysplastic white matter lesions/unidentified bright objects /Foci of abnormal signal intensities (FASi’s) in brain MRI are the commonest intracranial abnormality with Neurofibromatosis 1 seen in approximately 70-75% of patients. They are usually multiple, small in size and are typically located in globus pallidus, brainstem, centrum semiovale, thalamus, internal capsule, corpus callosum, and cerebellum. Although clinically silent, patients can present with reduced attention span however neuropsychological functioning of these lesions depends upon the region involved. NF1 lesions should be kept as differential for any hyperintense lesion in basal ganglia and caution is advised not to confuse these lesions with malignant lesions like gliomas as biopsies from these lesions showed benign etiology. Parental counselling regarding the prognosis is very important to alleviate unnecessary apprehension. Interval follow-up is advised for large lesions causing mass effect, showing contrast enhancement or when lesions are located in optic pathway.
THE EPIDEMIOLOGY OF MULTIPLE SCLEROSIS IN ROMANIA AND ACROSS CENTRAL AND SOUTHEASTERN EUROPE – A HISTORICAL REVIEW
Authors:   IInd Departament of Neurology, “V. Babes” University of Medicine and Pharmacy, Timisoara, Cornea A. , Rosca C. ,   IInd Departament of Neurology, “V. Babes” University of Medicine and Pharmacy, Timisoara, Petre A. ,   IInd Departament of Neurology, “V. Babes” University of Medicine and Pharmacy, Timisoara, Simu M. ,   IInd Departament of Neurology, “V. Babes” University of Medicine and Pharmacy, Timisoara
Published: September 2021

Background. Multiple sclerosis (MS) has a variable clinical and pathological course and pace, which eventually turns over years of that progression into a major source of disability especially among young adults. The regional incidence and prevalence data course are of utmost interest (i.e they tend to be higher in Europe within the last decade) mirroring diagnosis improvement, earlier and better treatment choices and an improved physio-pathological insight as shown by most recent studies. (1) The incidence and prevalence data tend to be higher in Europe within the last decade and are explained by diagnosis improvement and earlier and better treatment solutions for the patients mirrored by most recent studies. (1) The objective of the present study is to assess data available concerning the prevalence of multiple sclerosis in Romania and in Central and Southeastern Europe in a regional view. Material and method. A literature search has been performed in PubMed, DIMDI, Web of Science, and Google Scholar to retrieve population based studies in Central and Eastern Europe and epidemiological reviews through years 1960-2015. We searched the term “MS” combined with one of the following: “epidemiology” or “incidence” or “prevalence”. We also did a manual search of reference list of the relevant articles. Results. 38 studies met the inclusion criteria and were analyzed. The epidemiologic data available for Central and Eastern Europe during the period 1960-2015 support the heterogeneity both of this region’s resident population and of the studies design, making any global data assessment difficult, with a questionable reliability, therefore justifying a newer reappraisal.
VITAMIN D INTOXICATION IN A PATIENT WITH RELAPSING-REMITTING MULTIPLE SCLEROSIS – CASE REPORT
Authors:   Department of Neurology, Colentina Clinical Hospital, Bucharest, Cociasu Ioana , Davidescu Irene ,   Department of Neurology, Colentina Clinical Hospital, Bucharest,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Buraga Ioan ,   Department of Neurology, Colentina Clinical Hospital, Bucharest,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Popescu Bogdan Ovidiu ,   Department of Neurology, Colentina Clinical Hospital, Bucharest,   “Carol Davila” University of Medicine and Pharmacy, Bucharest,   Laboratory of Molecular Medicine and Neuroscience, ”Victor Babes” National Institute of Pathology, Bucharest
Published: September 2021

Lately, vitamin D has been a hot topic among multiple sclerosis specialists. Vitamin D supplementation is being thoroughly researched in order to establish whether or not it is useful in the treatment of multiple sclerosis. We present the case of a patient with multiple sclerosis, who, after searching online, decided to administer vitamin D supplements in high doses; subsequently he was admitted to our for clinic symptoms consistent with vitamin D intoxication.
LIMITATIONS OF VESTIBULAR REHABILITATION THERAPY USING DYNAMIC COMPUTERIZED POSTUROGRAPHY IN PATIENTS WITH CENTRAL VESTIBULAR SYNDROME
Authors:   Bucharest Emergency Hospital, Ulmeanu Anamaria Andreia , Didilescu Andreea ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Enache Raluca ,   Sarafoleanu Medical ENT Clinic, Bucharest, Musat Gabriela ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Sarafoleanu Codrut ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest
Published: September 2021

Objectives. To evaluate the importance of computerized dynamic posturography in vestibular rehabilitation (VR) of patients with central vestibular syndrome. Methods. The study included 30 patients with central vestibular syndrome with mean age (± SD) = 72.96 ± 11.97 which benefited from VR on a posturography platform between 2012-2014. All patients were evaluated using sensory integration tests. The parameters studied were: Romberg coefficient, statokinesigram (SKG), maximum amplitude of the degree of deviation in anterior-posterior and medial-lateral planes, SKG and the time interval of the rehabilitation program. Results. All of the analyzed parameters showed statistically significant results (p <0.05). The anterior-posterior and medio-lateral balance improved significantly at the end of the vestibular rehabilitation program and the parameters decreased to values close to normal. Conclusions. For patients with central vestibular syndrome, the vestibular rehabilitation improves postural stability and quality of life by reducing the risk of falls.
BRAINSTEM AUDITORY EVOKED POTENTIALS FINDINGS IN ANKYLOSING SPONDYLITIS
Authors:   “Gr. T. Popa” University of Medicine and Pharmacy Iasi, Romania, Stamate Iulia Georgiana ,   Rheumatology Clinic, Rehabilitation Hospital Iasi, Romania, Trofin Daniela Marilena ,   Neurology Clinic, Rehabilitation Hospital Iasi, Romania, Rezus Elena ,   “Gr. T. Popa” University of Medicine and Pharmacy Iasi, Romania,   Rheumatology Clinic, Rehabilitation Hospital Iasi, Romania, Popescu Cristian Dinu ,   “Gr. T. Popa” University of Medicine and Pharmacy Iasi, Romania,   Neurology Clinic, Rehabilitation Hospital Iasi, Romania
Published: September 2021

Background. Ankylosing spondylitis (AS) is a chronic inflammatory potentially debilitating disease predominantly affecting the axial skeleton. A few intermittently published studies and research have proved the existence of some not yet explained neurophysiologic abnormalities in patients with AS. Objectives. The aim of this study was to investigate the brainstem auditory evoked potentials and its relation with clinical findings, laboratory tests and pharmacological therapy used in patients with AS. Material and method. Thirty-nine patients with AS were included in the study. The control group was composed of 50 healthy subjects. BAEP were recorded for all subjects. Patients were assessed by clinical specific tests, inflammatory laboratory tests, Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and type of pharmacological therapy. Results. The results have shown differences between the control group and the patients with AS in most of the wave latencies. Correlations Schober test, Ott index, chest expansion measurement and BASDAI were significant for some waves. CRP seems to be more valuable than ESR as a possible marker for neurologic subclinical involvement. Axial AS is more likely to be associated with BAEP abnormalities. There were also differences between the group with TNF alpha blockers therapy comparative with the group with other therapies. Conclusions. This study highlights some abnormalities of BAEP in patients with AS. Diagnosis of multiple sclerosis or demyelination due to administration of TNF alpha blockers should be excluded in medical practice. Collaboration between neurologists and rheumatologists should be considered in monitoring AS patients.
PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY ASSOCIATED TO MULTIPLE SCLEROSIS THERAPIES: REVIEW OF THE LITERATURE
Authors:   Department of Neurology, Colentina Clinical Hospital, Bucharest, Vladila Ana-Maria , Mitrea Dan-Andrei ,   Department of Neurology, Colentina Clinical Hospital, Bucharest, Nica Sanda Maria ,   Department of Neurology, Colentina Clinical Hospital, Bucharest,   “Carol Davila” University of Medicine and Pharmacy”, Bucharest, Buraga Ioan ,   Department of Neurology, Colentina Clinical Hospital, Bucharest,   “Carol Davila” University of Medicine and Pharmacy”, Bucharest
Published: September 2021

Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection associated with the reactivation of the JC virus, causing a severe demyelination within the central nervous system in patients with immunosuppression caused by disease or secondary to use of drugs. Several therapies used in the treatment of MS have reported cases of associated PML, most cases being related to Natalizumab treatment. In this article we review specific MS medication with a reported risk for PML, and also revise PML epidemiology, pathogenesis, treatment and available approaches on therapy in patients at high risk for developing this infection.
RECURRENT MENINGIOMA AFTER INITIAL RESECTION SURGERY – CASE REPORT
Authors:   Department of Neurology, Colentina Clinical Hospital, Bucharest, Cociasu Ioana , Davidescu Irene ,   Department of Neurology, Colentina Clinical Hospital, Bucharest,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Buraga Ioan ,   Department of Neurology, Colentina Clinical Hospital, Bucharest,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Popescu Bogdan O. ,   Department of Neurology, Colentina Clinical Hospital, Bucharest,   “Carol Davila” University of Medicine and Pharmacy, Bucharest,   Laboratory of Molecular Medicine and Neuroscience, “Victor Babes” National Institute of Pathology, Bucharest
Published: September 2021

The most common tumours of the central nervous system, meningiomas are frequently diagnosed by accident when patients undergo imaging studies of the brain for other reasons. Most patients lack symptoms and thus can live their whole lives without knowing they have a brain tumour. Less fortunate patients seek medical advice for troubling symptoms – like seizures or disturbances of the cranial nerves – get surgery for the excision of the tumour and years later fi nd out their tumour has come back. We are presenting the case of such a patient with a recurrent parietal meningioma.
Phytochemical analysis of herbal teas containing caffeic acid
Authors:   Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania, TODORAN Mihai , HANGA Liana ,   Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania, BENEDEC Daniela ,   Department of Pharmacognosy, Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
Published: September 2021

Objectives. The present analysis was to investigate the content of caffeic acid derivatives, antioxidant activity, and the presence of caffeic acid in alcoholic extracts obtained from 16 simple teas from the following medicinal plants: Vaccinium mуrtilluѕ, Camеllia ѕinеnѕiѕ, Coffea arabica, Mеlіssa οffіcіnalіs, Οcіmum basіlіcum, Rοsmarіnus οffіcіnalіs, Salvіa οffіcіnalіs, Ηyssοрus οffіcіnalіs, Αrtеmіsіa absіntһіum, Cynara scοlymus, Calendula officinalis, Cοrіandrum satіvum, Fοеnіculum vulgarе, Carum carvі, Rοsa canіna, Crataеgus mοnοgyna. Materials and methods. The presence of caffeic acid was evaluated using the thin layer chromatography method (TLC). The total content of phenylpropanoids from the medicinal herbs alcoholic extracts was determined using a spectrophotometric method. Outcomes. Results were in the range of 0.046-2.426% caffeic acid derivatives (CAE%). The antioxidant properties were measured using the DPPH radical scavenging mechanism. The results were found to be in the range of 63.93% and 0.38% inhibition level (I%). The greatest antioxidant activity was measured for Camellia sinensis (I = 45.54%), followed by Vaccinium myrtillus (I = 50.289%). Conclusions. In this paper it was shown that these medicinal plants are rich in caffeic acid derivatives with antioxidant action capitalized in the prevention of serious diseases.
Cytotoxic activity of Pinus cembra L. needle extract: A preliminary study on HeLa cell line
Authors:   “Grigore T. Popa“ University of Medicine and Pharmacy, Iasi, Romania, LUNGU Cristina , MIHAI Cosmin-Teodor ,   Advanced Centre for Research and Development in Experimental Medicine (CEMEX), “Grigore T. Popa“ University  of Medicine and Pharmacy, Iasi, Romania,   Institute of Biological Research/National Institute of Research and Development for Biological Sciences, Iasi, Romania, VOCHITA Gabriela ,   Institute of Biological Research/National Institute of Research and Development for Biological Sciences, Iasi, Romania, GHERGHEL Daniela ,   Institute of Biological Research/National Institute of Research and Development for Biological Sciences, Iasi, Romania, MIRON Sorin-Dan ,   “Grigore T. Popa“ University of Medicine and Pharmacy, Iasi, Romania, APROTOSOAIE Ana Clara ,   “Grigore T. Popa“ University of Medicine and Pharmacy, Iasi, Romania, MIRON Anca ,   “Grigore T. Popa“ University of Medicine and Pharmacy, Iasi, Romania
Published: September 2021

The aim of this study was to investigate the cytotoxic effects of a hydromethanolic extract obtained from cembran pine needles in HeLa cell line. In this respect, the effects of needle extract on protein synthesis, viability, proliferation and cell cycle in HeLa cells were evaluated after 48 h treatment. Cembran pine needle extract dose-dependently decreased protein synthesis in HeLa cells causing 44.26% reduction in protein synthesis at 100µg/ml. At 25, 50 and 100µg/ml, it increased cell death in comparison with the control (20.99%, 21.49% and 23.63%, respectively vs. 9.83%). In addition, at 100µg/ml, cembran pine needle extract showed a remarkable antiproliferative effect whereas at 25 and 50µg/ml, it induced sub-G1 phase cells accumulation (11.68 ± 0.81% and 14.69 ± 0.56%, respectively in comparison with control, 6.03 ± 0.55%), an indicator of proapoptotic effects. Taken together, these results indicate that cembran pine needles are a source of compounds with antitumor potential which needs to be further investigated and exploited.
The place of combination of lercanidipine – enalapril in the treatment of hypertension: efficacy, safety, special features
Authors: Barna O. M.
Published: September 2021

In order to improve the effectiveness of antihypertensive treatment, doctors more often prescribe fixed dose combinations of two or three antihypertensive products. In this case, the concomitant effects of these products contribute to better control of blood pressure, improve patient’s adherence to treatment and reduce the risk of side effects. The fixed dose combination of lercanidipine and enalapril is quite new for Ukrainian physicians; however, there is already a sufficient evidence base for the efficacy and safety of such combination therapy. Lecranidipine – enalapril combination reduce systolic and diastolic blood pressure in patients with moderate hypertension without severe side effects. In addition, this combination is effective and safe in patients with comorbidities.
Antichelicobacter therapy in the context of increasing bacterial resistance
Authors: Korost Ya. V. , Gorobets N. M.
Published: September 2021

A modern strategy for the treatment of diseases associated with Helicobacter pylori is the mandatory inclusion in the scheme of treatment of antibiotics, as well as considering the level of bacterial resistance to the main components of therapy. In Ukraine, Helicobacter pylori infection in some areas can reach about 80%, so the prevalence of peptic ulcer, atrophic gastritis and other diseases of the gastrointestinal tract is extremely high in all sections of the population. Topical for our country is the use of standard triple antyhelicobacter therapy, which includes: proton pump inhibitor in combination with clarithromycin + amoxicillin. Such therapy lasting 10 or 14 days allows to completely free the gastrointestinal tract from Helicobacter pylori, and to prevent the further development of pathological process on the mucous membrane. This tactic can successfully prevent the growth of incidence of gastric lymphoma, cancer of the stomach, as well as reduce the likelihood of complications in peptic ulcers.
Pain, depression and anxiety: is there a light at the end of the tunnel?
Authors: Burchinsky S. G.
Published: September 2021

In the present paper a modern sights to problem of chronic psychogenic pain and its relation to depressive and anxiety disorders have been looked. Based on this point of view, the requirements to choice of optimal pharmacological tool within complex therapy of psychogenic pain, depression and anxiety have been analyzed. A main attention paid to mechanisms of action and peculiarities of clinical use of drugs: duloxetine (Revival) – antidepressant from SNRI group with unique mechanisms of action and clinico-pharmacological properties, which make possible to realize the on-time impact on the mechanisms of development of depression and psychogenic pain; and pregabaline (Ligato) – drug from the anticonvulsants group, which influenced on universal mechanisms of cell ionic permeability at anxiety disorders and psychogenic pain. A clinical efficacy of duloxetine (Revival) and pregabaline (Ligato), its safety characteristics, and recommendations of practical use have been looked in detail.
Features of prophylactic treatment in patients with different forms of migraine, complicated by migraine status
Authors: Didkova I. P.
Published: September 2021

The purpose of this study was to study the dynamics of indicators of the scale of Migraine Disability Assessment (MIDAS) in patients with different forms of migraine, which is complicated by migraine status due to the use of prophylactic treatment. 50 patients suffering from migraine, complicated by migraine status, have been examined and treated in the neurological department of the Kyiv Railway Clinical Hospital №2. The degree of pain has been assessed on a visual analog scale (VAS) and the level of disability has been assessed on MIDAS. The solution of valproate acid was used in the main group of patients for the treatment of migraine status during three days. The traditional vasoactive and dehydration therapy was used in the control group within ten days. It was proved, that the solution of preparation of valproic acid for treatment of status migrainous authentically increases degree of headache and level of disadaptation in patients during 6 months. Migraine attacks continued to lead to loss of working capacity and daily activity of patients in the control group. Treatment was safe for patients and well tolerated.Our study showed that the use of solution of valproate acid in the treatment of migraine status in patients with different forms of migraine is authentic effective and leads to decrease the degree of disadaptation in patients during 6–8 months after treatment.
Is there life after acute coronary syndrome?
Authors: Yagensky A. V.
Published: September 2021

The role of coronary heart disease and acute coronary syndrome in the structure of morbidity and mortality of the population of Ukraine cannot be overestimated. The main pathogenetic mechanism of corticosteroids is atherothrombosis, the influence of which is the basis of treatment of patients with coronary heart disease with or without corticosteroids. The effect on the progression of atherothrombosis is possible due to statins, due to slowing the growth of atherosclerotic plaques in blood vessels by reducing the level of low-density lipoproteins in the blood.
Nocturnal hypertension syndrome in combination with orthostatic hypotension: a complex scenario in the treatment of hypertension
Authors: Mishchuk N. E.
Published: September 2021

One of the most difficult scenarios in the treatment of hypertension is the syndrome of neurogenic orthostatic hypotension - hypertension in the supine position.Despite the large number of observations, publications and even a number of randomized studies, this syndrome remains poorly known and often remains unrecognized. In this regard, in 2017, the recommendations of leading experts in the United States and Canada on screening, diagnosis and treatment of neurogenic orthostatic hypertension and associated hypertension in the supine position were published.The principles and features of the diagnosis of this syndrome are given on the example of the medical history of patient Sh., Which has been observed in our clinic since 2019.
Strategy and choice criteria’s of initial disturbances of brain circulation in family physician’s practice
Authors: Burchinsky S. G.
Published: September 2021

In the present paper a modern sights to manifestations of initial stages of brain ischemia and its role in damage of CNS in cerebrovascular pathology have been looked. Based on this point of view, the requirements to choice of optimal pharmacological strategy concerning correction of brain pathological changes during ischemia, and particularly neurometabolic pharmacotherapy’ advantages have been analyzed. A basic goals of clinical use of neuroprotection’s strategy in generally, and particularly neurometabolic pharmacotherapy have been looked. A main attention paid to mechanisms of action and peculiarities of clinical use of drug Dinar (ethyl-methyl-hydroxypiridine succinat) and its possibilities in plane to realization of pathogenetically grounding neurometabolic pharmacotherapy of initial stages of cerebrovascular pathology. A clinical efficacy of Dinar and its safety characteristics have been looked in detail.
Theoretical aspects of inulin use in patients with osteoarthritis
Authors: Sabadishin R. O.
Published: September 2021

Primary osteoarthritis accounts for about 80% of all joint diseases. The disease mainly affects people of working age, which has social significance. The number of patients with DOA is constantly increasing, as life expectancy increases, as a result of excessive food intake, body weight increases, which leads to increased stress on the joints. Important for the treatment of osteoarthritis is the use of inulin, which affects the growth of bone tissue, promotes their regeneration in case of damage by pathological processes, which will significantly improve the patient’s condition and his full recovery.
ESPIRITUALIDADE E PSIQUIATRIA: ATENÇÃO À SAÚDE MENTAL NA DIMENSÃO PSICOSSOCIAL E ESPIRITUAL
Authors: Moreira da Silveira Francis
Published: September 2021

A dimensão psicossocial e espiritual tem sido bastante debatida e valorizada em época contemporânea. A espiritualidade como coadjuvante na busca pela saúde mental, revelando-se importante estudar sobre o assunto que repercute diretamente sobre a atenção à saúde mental. O artigo objetiva discorrer sobre a relação espiritualidade e saúde mental, buscando ainda demonstrar como pode se dar a atenção à saúde mental considerando-se a dimensão espiritual e psicossocial. Possui por objetivo geral estudar a atenção à saúde mental na dimensão psicossocial, em especial com relação a espiritualidade. Possui ainda por objetivos específicos analisar a saúde mental no Brasil; discorrer sobre a atenção em saúde mental no contexto brasileiro; estudar como ocorrer a atenção à saúde mental no Brasil com relação a espiritualidade; discorrer sobre como a espiritualidade pode auxiliar na atenção à saúde mental, e por fim trazer soluções para que a espiritualidade seja valorizada na dimensão biopsicossocial e dapsiquiatria. Para isso a metodologia adotada foi a bibliográfica, através da pesquisa qualitativa que se adequa aos fins propostos no presente artigo. Conclui-se que a espiritualidade é fator preponderante para a saúde mental somado a dimensão psicossocial no âmbito dos tratamentos psiquiátricos.
Beyond Hand Waving: Indices For Hymn Leading in Corporate Christian Worship
Authors: Ogunleye Adeolu
Published: September 2021

The paper examines the significance of the selection, planning, and factors that affect the leading and singing of hymns in corporate Christian worship. While myriads of scholarly literature abound on hymnology, through bibliographies and an in-depth library search, the paper seeks to discuss the guidelines that engender the leading of congregation hymns and methods required for a dynamic leading of hymns. The research findings reveal that in some Nigerian churches where there are no trained music ministers, many untrained song leaders merely stand before the congregation to announce the hymns for the congregation to sing without performing a leadership role. Others merely stand to wave a hand. Leading congregational hymns requires training and vivaciousness in skill application. The three major areas of focus include planning, leading, and congregational response to hymn singing. The paper concludes that planning and selection of hymns are both spiritual and intellectual
exercises that involve basic knowledge of the rudiments of music. The research will help the church musicians and academics in further research into church music and congregational hymn singing.

Keywords: Song Leader, Hymn, Hymnody, Worship, Corporate Christian Worship
Lunar Surface Composition Constraints from Maturity-corrected Far-ultraviolet Reflectance Maps
Authors: Byron Benjamin D. , Retherford Kurt D. , Czajka Elizabeth , Cahill Joshua T. S. , Hendrix Amanda R. , Greathouse Thomas K.
Published: September 2021

Far-ultraviolet (FUV) observations by the Lunar Reconnaissance Orbiter Lyman Alpha Mapping Project (LAMP) have shown that the lunar surface reflectance in the ultraviolet is sensitive to changes in both composition and maturity at wavelengths >170 nm. This can lead to uncertainties in the interpretation of features that appear in maps created using LAMP data from this wavelength range. Here we utilize a correction based on the optical maturity parameter to remove large-scale immaturity features from LAMP spectral slope and band ratio maps. After performing the correction, the LAMP maps more accurately represent the FUV lunar surface in the context of composition. Corrected LAMP maps show good correlation with lunar FeO, plagioclase, and bulk silicate abundance maps for moderate- to high-iron regions, indicating a sensitivity in the LAMP data to differences in mineral composition in those regions. These maps represent a unique view into a relatively unexplored region of the spectrum and showcase the ability to perform compositional mapping and mineral identification using FUV remote-sensing measurements.
Dietary live yeast (Debaryomyces hansenii) provides no advantages in tropical gar, Atractosteus tropicus (Actinopterygii: Lepisosteiformes: Lepisosteidae), juvenile aquaculture
Authors: Hernández-López Iris Adriana , Tovar-Ramírez Dariel , De la Rosa-García Susana , Álvarez-Villagómez Carina Shianya , Asencio-Alcudia Gloria Gertrudys , Martínez-Burguete Talhia , Galaviz Mario Alberto , Guerrero-Zárate Rocío , Martínez-García Rafael , Peña-Marín Emyr Saúl , Álvarez-González Carlos Alfonso
Published: September 2021

Tropical gar, Atractosteus tropicus Gill, 1863, is an ancient freshwater fish that is commercially cultivated in southern Mexico. Currently, there is a specific diet for its culture; however, the addition of probiotics has not been investigated. The objective of this study was to evaluate the supplementation of live yeast Debaryomyces hansenii for A. tropicus juveniles on growth, productive parameters, survival, somatic index, digestive enzyme activity, and immune system gene expressions (interleukin 10, il-10, Transforming growth factor β1, tgf-β1, and β2 microglobulin, b2m). Three experimental diets increased the dose of live yeast (0.5, 1.0, and 1.5%; 1014, 1015, and 1016CFU g diet–1, respectively) and a control diet (CD; without yeast) were designed. Daily weight gain and specific growth rate were higher in fish fed with CD and 0.5% D. hansenii. High activities of trypsin, chymotrypsin LAP, and α-amylase, as well as overexpression of il-10 in the spleen, were detected in fish feed 0.5% D. hansenii. The inclusion of D. hansenii had no positive effect on aquaculture for A. tropicus, lower doses should be tested to optimize the diet.
Having Your Cake and Eating It Too: JSON-LD as an RDF serialization format
Authors: Baskauf Steven J
Published: September 2021

One impediment to the uptake of linked data technology is developers’ unfamiliarity with typical Resource Description Framework (RDF) serializations like Turtle and RDF/XML. JSON for Linking Data (JSON-LD) is designed to bypass this problem by expressing linked data in the well-known Javascript Object Notation (JSON) format that is popular with developers. JSON-LD is now Google’s preferred format for exposing Schema.org structured data in web pages for search optimization, leading to its widespread use by web developers. Another successful use of JSON-LD is by the International Image Interoperability Framework (IIIF), which limits its use to a narrow design pattern, which is readily consumed by a variety of applications. This presentation will show how a similar design pattern has been used in Audubon Core and with Biodiversity Information Standards (TDWG) controlled vocabularies to serialize data in a manner that is both easily consumed by conventional applications, but which also can be seamlessly loaded as RDF into triplestores or other linked data applications. The presentation will also suggest how JSON-LD might be used in other contexts within TDWG vocabularies, including with the Darwin Core Resource Relationship terms.
Hacking Infrastructures Together: Towards better interoperability of infrastructures
Authors: Meeus Sofie , Addink Wouter , Agosti Donat , Arvanitidis Christos , Dimitrova Mariya , González-Aranda Juan Miguel , Holetschek Jörg , Islam Sharif , Jeppesen Thomas , Mietchen Daniel , Robertson Tim , Sanchez Cano Francisco , Trekels Maarten , Groom Quentin
Published: September 2021

The BiCIKL Project is born from a vision that biodiversity data are most useful if they are viewed as a network of data that can be integrated and viewed from different starting points. BiCIKL’s goal is to realize that vision by linking biodiversity data infrastructures, particularly for literature, molecular sequences, specimens, nomenclature and analytics. BiCIKL is an Open Science project creating Open FAIR data and services for the whole research community. BiCIKL intends to inspire novel, innovative, research and build services that can produce new and valuable knowledge, necessary for the protection of biodiversity and of our environment. BiCIKL will develop methods and workflows to harvest, link and access data extracted from literature. Yet, as the project gets underway, we need to better understand the existing infrastructures, their limitations, the nature of the data they hold, the services they provide and particularly how they can interoperate. To do this we organised a week-long hackathon where small teams worked on a number of pilot projects (Table 1) that were chosen to test the existing linkages between infrastructures and to extract novel ones.

We will present our experience of running a hackathon and our evaluation of how successfully it achieved its aims. We will also give examples of the projects we conducted and how successful they were. Finally we will give our preliminary evaluation of what we learned about the interoperability of infrastructures and what recommendations we can give to improve their interoperability, whether that is improvements to the data standards used, the means to access the data and analyse them, or even the physical bandwidth and computational restrictions that limit the potential for research.
Existence and concentration of positive solutions for a p-fractional Choquard equation
Authors: Shang Xudong ,   School of Mathematics, Nanjing Normal University Taizhou College, 225300, Jiangsu, China
Published: September 2021

In this work, we study the existence, multiplicity and concentration behavior of positive solutions for the following problem involving the fractional $ p $-Laplacian

   \begin{document}$ \begin{eqnarray*} \varepsilon^{ps}(-\Delta )^{s}_{p}u + V(x)|u|^{p-2}u = \varepsilon^{\mu-N}(\frac{1}{|x|^{\mu}}\ast K|u|^{q})K(x)|u|^{q-2}u \hskip0.2cm\text{in}\hskip0.1cm \mathbb{R}^{N}, \end{eqnarray*} $\end{document}

where $ 0 < s < 1 < p < \infty $, $ N > ps $, $ 0 < \mu < ps $, $ p < q < \frac{p^{*}_{s}}{2}(2-\frac{\mu}{N}) $, $ (-\Delta)^{s}_{p} $ is the fractional $ p $-Laplacian and $ \varepsilon > 0 $ is a small parameter. Under certain conditions on $ V $ and $ K $, we prove the existence of a positive ground state solution and express the location of concentration in terms of the potential functions $ V $ and $ K $. In particular, we relate the number of solutions with the topology of the set where $ V $ attains its global minimum and $ K $ attains its global maximum.
On investigations of graphs preserving the Wiener index upon vertex removal
Authors: Hu Yi ,   School of Information Science and Technology, South China Business College of Guangdong University of Foreign Studies, 510545, Guangzhou, China, Zhu Zijiang , Wu Pu , Shao Zehui , Fahad Asfand ,   Institute for Intelligent Information Processing, South China Business College of Guangdong University of Foreign Studies, 510545, Guangzhou, China,   Institute of Computing Science and Technology, Guangzhou University, Guangzhou 510006, China,   Department of Mathematics, COMSATS University Islamabad, Vehari Campus, Vehari 61100, Pakistan
Published: September 2021

In this paper, we present solutions of two open problems regarding the Wiener index $ W(G) $ of a graph $ G $. More precisely, we prove that for any $ r \geq 2 $, there exist infinitely many graphs $ G $ such that $ W(G) = W(G - \{v_1, \ldots, v_r\}) $, where $ v_1, \ldots, v_r $ are $ r $ distinct vertices of $ G $. We also prove that for any $ r \geq 1 $ there exist infinitely many graphs $ G $ such that $ W(G) = W(G - \{v_i\}) $, $ 1 \leq i \leq r $, where $ v_1, \ldots, v_r $ are $ r $ distinct vertices of $ G $.
Generalizations of strongly hollow ideals and a corresponding topology
Authors: Çeken Seçil ,   Trakya University, Faculty of Science, Department of Mathematics, Edirne, Turkey, Yüksel Cem
Published: September 2021

In this paper, we introduce and study the notions of $ M $-strongly hollow and $ M $-PS-hollow ideals where $ M $ is a module over a commutative ring $ R $. These notions are generalizations of strongly hollow ideals. We investigate some properties and characterizations of $ M $-strongly hollow ($ M $-PS-hollow) ideals. Then we define and study a topology on the set of all $ M $-PS-hollow ideals of a commutative ring $ R $. We investigate when this topological space is irreducible, Noetherian, $ T_{0} $, $ T_{1} $ and spectral space.
Development of a Diagnostic Coronagraph for Use on the International Space Station
Authors: KIM Yeon-Han , CHO Kyungsuk , CHOI Seonghwan , BONG Su-Chan , Team Coronagraph
Published: September 2021

The Korea Astronomy and Space Science Institute (KASI), in collaboration with the NASA Goddard Space Flight Center (GSFC), has been developing a diagnostic coronagraph to be deployed in 2023 on the International Space Station (ISS). The mission is known as “Coronal Diagnostic Experiment (CODEX)”, which is designed to obtain simultaneous measurements of the electron density, temperature, and velocity in the 2.5- to 10-Rs range by using multiple filters. The coronagraph will be installed and operated on the ISS to understand the physical conditions in the solar wind acceleration region and to enable and validate the next generation space weather models.
O Impacto da Diversidade de Produtos na Relação entre Internacionalização e Desempenho de Empresas Brasileiras Multinacionais
Authors: Dias Vitor Fonseca Machado Beling , Penedo Antônio Sergio Torres , Pereira Vinicius Silva
Published: September 2021

O objetivo deste estudo foi investigar o papel moderador da diversificação de produtos na relação entre internacionalização e desempenho de empresas brasileiras multinacionais. Este estudo utilizou dados de internacionalização coletados em relatórios da Fundação Dom Cabral, dados financeiros coletados na base de dados do Economática, além de dados secudários de 33 empresas brasileiras coletados no site da Comissão de Valores Mobiliários (CVM). O trabalho se refere a um período de oito anos (2010 a 2017), e utilizou regressão linear múltipla com efeitos fixos e dados em painel. Foi identificado que a relação entre internacionalização e desempenho de empresas brasileiras multinacionais se dá em formato de U. Ademais, foi identificado um papel moderador negativo na relação entre diversificação de produtos e internacionalização em baixo grau, e um efeito moderador positivo no desempenho de empresas brasileiras internacionalizadas com alto grau de diversificação de produtos. O presente trabalho inovou nessa temática para a literatura brasileira ao focar no efeito moderador da diversidade de produtos. Além disso, o artigo  possui implicações para empresas brasileiras multinacionais, pois pode auxiliar o planejamento relacionado à expansão internacional delas, e também destaca que os efeitos benéficos da internacionalização não são imediatos; que os conhecimentos e experiências adquiridos nesse processo são importantes para melhorar sua performance; e que após estágios iniciais do processo de internacionalização, a diversificação de produtos pode auxiliar no que diz respeito a uma melhoria no desempenho dessas empresas.
Threat and Risk Assessment Using Continuous Logic
Authors: Dasso Aristides , Funes Ana
Published: September 2021

Threat and Risk Assessment is an important area in cybersecurity. It covers multiple systems and organizations where cybersecurity is significant, such as banking, industry, SCADA, Energy Management System, among many others. The chapter presents a method to help assessing threats and risks associated with computer and networks systems. It integrates the Framework for Improving Critical Infrastructure Cybersecurity—developed by the National Institute of Standards and Technology—with a quantitative method based on the use of a Continuous Logic, the Logic Scoring of Preference (LSP) method. LSP is a method suitable for decision making that provides the guidelines to produce a model to assist the expert in the process of assessing how much a product or system satisfy a number of requirements, in this case associated to the identification, protection, detection, response and recovery of threat and risks in an organization.
Internal Marketing Cybersecurity-Conscious Culture
Authors: Bowen Gordon , Sethi Atul
Published: September 2021

The chapter is putting forward the idea that internal marketing is a tool of which there are many to embed a culture to combat cybersecurity threats. This conceptual paper is suggesting that cybersecurity threats are multi-facet and although internal marketing is a major contributing factor in reducing the threats, other factors are in play. The shape of the organisation (i.e., bureaucratic or organic) has an important bearing on the implementation of a marketing-oriented culture, including that of internal marketing and, thus, the success of a cybersecurity-conscious organisational culture. Another significant factor in creating a cybersecurity-conscious organisational culture is the management willingness to empower and employees and their willingness to accept the responsibility to make decisions and be accountable, which requires acceptance of the authority.