bluuebunny/crossref_metadata_2025 huggingface dataset:
Sustainability Design Considerations for Timber‐Concrete Composite Floor Systems
Authors: Mirdad Md Abdul Hamid , Daneshvar Hossein , Joyce Thomas , Chui Ying Hei
Published: March 2021

Over the last few decades, there has been growing interest in the use of low‐carbon materials to reduce the environmental impacts of the construction industry. The advent of mass timber panels (MTP), such as cross laminated timber (CLT), has allowed structural engineers to specify a low‐carbon material for a variety of floor design considerations. However, serviceability issues such as vibration and deflection are limiting the construction of longer span timber‐only floor systems and have encouraged the development of timber‐concrete composite (TCC) systems. The use of concrete would negatively impact on the carbon footprint of the TCC floor system and should be minimized. The purpose of this study was to study the impact on embodied carbon in the TCC system, when the ratio of timber and concrete was varied for specific floor spans. Two MTP products were considered, CLT and glued laminated timber (GLT). The floors were designed to satisfy structural, acoustic, and vibration criteria, and the results were presented in the form of span tables. It was found that using thicker MTP instead of adding concrete thickness to meet a specific span requirement can lead to lower embodied carbon values. Increasing concrete thickness for long‐span floor systems led to a reduction in allowable floor span due to the vibration criterion being the controlling design parameter. Increasing timber thickness also resulted in higher strength and stiffness to weight ratios, which would contribute toward reducing the size of lateral load resisting systems and foundations, resulting in further reductions in the embodied carbon of the entire structure.
Disturbance Rejection Attitude Control for a Quadrotor: Theory and Experiment
Authors: Ding Li , He Qing , Wang Chengjun , Qi Rongzhi
Published: March 2021

In this article, an attitude tracking controller is designed for a quadrotor unmanned aerial vehicle (UAV) subject to lumped disturbances. Firstly, the attitude dynamical model of the quadrotor under external disturbances is established. Subsequently, an improved sliding mode control (SMC) strategy is designed based on the linear extended state observer (LESO). In this control scheme, the SMC will guarantee the sliding surface is finite time reachable and the LESO will estimate and compensate for the lumped disturbances. Then, the robustness and asymptotic stability of the proposed controller are proved by the stability analyses. Finally, three numerical simulation cases and comparative flight experiments validate the effectiveness of the developed controller.
Feature Tracking for Target Identification in Acoustic Image Sequences
Authors: Gao Jue , Gu Ya , Zhu Peiyi
Published: March 2021

This paper proposes underwater target identification with local features and a feature tracking algorithm for acoustic image sequences. Feature detectors and descriptors are key to feature tracking. Their performance in underwater scene is evaluated by the change of multitarget parameters. A comprehensive quantitative investigation into the performance of feature tracking is thereby presented. Experimental results confirm that the proposed algorithm can accurately track potential targets and determine whether the potential targets are static targets, dynamic targets, or false alarms according to the tracking trajectories and statistical data.
Clinical Impact of Presurgery Circulating Tumor DNA after Total Neoadjuvant Treatment in Locally Advanced Rectal Cancer: A Biomarker Study from the GEMCAD 1402 Trial
Authors: Vidal Joana , Casadevall David , Bellosillo Beatriz , Pericay Carles , Garcia-Carbonero Rocio , Losa Ferran , Layos Laia , Alonso Vicente , Capdevila Jaume , Gallego Javier , Vera Ruth , Salud Antonieta , Martin-Richard Marta , Nogué Miguel , Cillán Elena , Maurel Joan , Faull Iris , Raymond Victoria , Fernández-Martos Carlos , Montagut Clara
Published: March 2021

Purpose:

Total neoadjuvant treatment (TNT) is a valid strategy for patients with high-risk locally advanced rectal cancer (LARC). Biomarkers of response to TNT are an unmet clinical need. We aimed to determine the value of circulating tumor DNA (ctDNA) to predict tumor response, recurrence, and survival in patients with LARC treated with TNT.

Experimental Design:

The GEMCAD 1402 was a phase II randomized, multicentric clinical trial that randomized 180 patients with LARC to modified schedule of fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) +/− aflibercept, followed by chemoradiation and surgery. Plasma samples were collected at baseline and after TNT within 48 hours before surgery (presurgery). An ultrasensitive assay that integrates genomic and epigenomic cancer signatures was used to assess ctDNA status. ctDNA results were correlated with variables of local tumor response in the surgery sample, local/systemic recurrence, and survival.

Results:

A total of 144 paired plasma samples from 72 patients were included. ctDNA was detectable in 83% of patients at baseline and in 15% following TNT (presurgery). No association was found between ctDNA status and pathologic response. Detectable presurgery ctDNA was significantly associated with systemic recurrence, shorter disease-free survival (HR, 4; P = 0.033), and shorter overall survival (HR, 23; P < 0.0001).

Conclusions:

In patients with LARC treated with TNT, presurgery ctDNA detected minimal metastatic disease identifying patients at high risk of distant recurrence and death. This study sets the basis for prospective clinical trials that use liquid biopsy to personalize the therapeutic approach following TNT.
Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome
Authors: Liudahl Shannon M. , Betts Courtney B. , Sivagnanam Shamilene , Morales-Oyarvide Vicente , da Silva Annacarolina , Yuan Chen , Hwang Samuel , Grossblatt-Wait Alison , Leis Kenna R. , Larson William , Lavoie Meghan B. , Robinson Padraic , Dias Costa Andressa , Väyrynen Sara A. , Clancy Thomas E. , Rubinson Douglas A. , Link Jason , Keith Dove , Horton Wesley , Tempero Margaret A. , Vonderheide Robert H. , Jaffee Elizabeth M. , Sheppard Brett , Goecks Jeremy , Sears Rosalie C. , Park Byung S. , Mori Motomi , Nowak Jonathan A. , Wolpin Brian M. , Coussens Lisa M.
Published: March 2021

Immunotherapies targeting aspects of T cell functionality are efficacious in many solid tumors, but pancreatic ductal adenocarcinoma (PDAC) remains refractory to these treatments. Deeper understanding of the PDAC immune ecosystem is needed to identify additional therapeutic targets and predictive biomarkers for therapeutic response and resistance monitoring. To address these needs, we quantitatively evaluated leukocyte contexture in 135 human PDACs at single-cell resolution by profiling density and spatial distribution of myeloid and lymphoid cells within histopathologically defined regions of surgical resections from treatment-naive and presurgically (neoadjuvant)–treated patients and biopsy specimens from metastatic PDAC. Resultant data establish an immune atlas of PDAC heterogeneity, identify leukocyte features correlating with clinical outcomes, and, through an in silico study, provide guidance for use of PDAC tissue microarrays to optimally measure intratumoral immune heterogeneity. Atlas data have direct applicability as a reference for evaluating immune responses to investigational neoadjuvant PDAC therapeutics where pretherapy baseline specimens are not available.

Significance:

We provide a phenotypic and spatial immune atlas of human PDAC identifying leukocyte composition at steady state and following standard neoadjuvant therapies. These data have broad utility as a resource that can inform on leukocyte responses to emerging therapies where baseline tissues were not acquired.

This article is highlighted in the In This Issue feature, p. 1861
Erythrodermic CD4/CD8 Double-Negative Mycosis Fungoides: A Case Report
Authors: Alnasser Monira Abdullah , AlKhawajah Nour Marwan , AlQadri Nada Ghazi , Shadid Asem Mustafa , Alsaif Fahad M.
Published: March 2021

Cutaneous T-cell lymphoma (CTCL) describes a group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin. Mycosis fungoides (MF) represents the most common type of CTCL and accounts for ∼60% of all primary cutaneous lymphomas. Apart from the classic type of MF, many clinical and histopathologic variants have been described. The malignant lymphocytes in MF are usually CD3, CD4 and CD45RO positive and CD8 negative. An unusual immunohistochemical profile of a CD4-negative and CD8-positive mature T-cell phenotype has been reported in a minority of patients; up to 20% of early-stage MF demonstrates a CD8-positive phenotype. There are only a few cases of a double-negative CD4/CD8 MF phenotype reported in the literature. We present the case of a 60-year-old male presenting a double-negative CD4/CD8 MF phenotype.
Proposition of local automatic algorithm for landmark detection in 3D cephalometry
Authors: Ed-dhahraouy Mohammed , Riri Hicham , Ezzahmouly Manal , Moutaouakkil Abdelmajid El , Aghoutan Hakima , Bourzgui Farid
Published: March 2021

This study proposes a new contribution to solve the problem of automatic landmarks detection in three-dimensional cephalometry. 3D images obtained from CBCT (cone beam computed tomography) equipment were used for automatic identification of twelve landmarks. The proposed method is based on a local geometry and intensity criteria of skull structures. After the step of preprocessing and binarization, the algorithm segments the skull into three structures using the geometry information of nasal cavity and intensity information of the teeth. Each targeted landmark was detected using local geometrical information of the volume of interest containing this landmark. The ICC and confidence interval (95% CI) for each direction were 0, 91 (0.75 to 0.96) for x- direction; 0.92 (0.83 to 0.97) for y-direction; 0.92 (0.79 to 0.97) for z-direction. The mean error of detection was calculated using the Euclidian distance between the 3D coordinates of manually and automatically detected landmarks. The overall mean error of the algorithm was 2.76 mm with a standard deviation of 1.43 mm. Our proposed approach for automatic landmark identification in 3D cephalometric was capable of detecting 12 landmarks on 3D CBCT images which can be facilitate the use of 3D cephalometry to orthodontists.
Implement of multiple access technique by wireless power transfer and relaying network
Authors: Le Anh-Tu , Do Dinh-Thuan
Published: March 2021

In this paper, we investigate non-orthogonal multiple access (NOMA) network relying on wireless power transfer to prolong lifetime. The base station (BS) sends common signals to the relay with two functions (energy harvesting (EH) and signal processing) to further serve two NOMA users in downlink. Performance gap exists since different power allocation factor assigned from power splitting protocol adopted at the relay and such relay employs both amplify-and-forward (AF) and decode-and-forward schemes. To provide performance metrics, we prove formulas of the outage probability which is a function of transmit signal to noise ratio. Simulation results indicate specific parameters to adjust system performance of two user in the considered EH-NOMA system. This finding is important recommendation to design EH-NOMA which shows particular outage performance at required target rates.
Controller design for underwater robotic vehicle based on improved whale optimization algorithm
Authors: Hasan Mustafa Wassef , Abbas Nizar Hadi
Published: March 2021

This paper presents the impact of introducing a two-controller on the linearized autonomous underwater vehicle (AUV) for vertical motion control. These controllers are presented to overcome the sensor noise of the AUV control model that effect on the tolerance and stability of the depth motion control. Linear quadratic Gaussian (LQG) controller is cascaded with AUV model to adapt the tolerance and the stability of the system and compared with FOPID established by the improved whale optimization algorithm (IWOA) to identify which controlling method can make the system more harmonize and tolerable. The developed algorithm is based on improving the original WOA by reshaping a specific detail on WOA to earn a warranty that the new IWOA will have values for the update position lower than the identified lower-bound (LB), and upper-bound (UB). Furthermore, the algorithm is examined by a set of test functions that include (unimodal, multimodal and fixed dimension multimodal functions). The privileges of applying IWOA are reducing the executing time and obtaining the semi-optimal objective function as compared with the original WOA algorithm and other popular swarm-intelligence optimization algorithms.
Real-time monitoring of clinic risks using an integrated RFID-FA scheme
Authors: Hussein Nisreen A. , Fayyadh Mohammed M.
Published: March 2021

Patient safety is a global public health concern because of increases in the number of mistreatments due to the improper identification of patients or the improper administration of drugs. Risk in clinic management refers to the systematic process used to specify, control, and analyze organizational risks. The present article developed a new method to detect different objects automatically in real-time by monitoring and controlling the hospital workflow using radio frequency identification (RFID). The system methodology starts with identifying the functional area by detecting the room optical characters. Then clustering and matching the symmetrical functional area using histogram matching technique. For the monitoring process, the radio frequency network planning RNP has been used. Density-based scan algorithm (DBSCAN) was used for clustering and extracting the area, then all gathered data transferred to the firefly algorithm to track drug distribution and specify doctor and nurse locations. The simulation results observe real-time tracking and identification of people and drugs based on hospital zone designs. The results present 87% tag real-time coverage for managing and monitoring human inside the hospital. The effectiveness of this system shows that it was useful in monitoring clinic operations and effective for a hospital network solution.
Hardware-in-the-loop based comparative analysis of speed controllers for a two-mass system using an induction motor drive with ideal stator current performance
Authors: Ha Vo Thanh , Nguyen Tung Lam , Ha Vo Thu
Published: March 2021

A comparative study of speed control performance of an induction motor drive system connecting to a load via a non-rigid shaft. The nonrigidity of the coupling is represented by stiffness and damping coefficients deteriorating speed regulating operations of the system and can be regarded as a two-mass system. In the paper, the ability of flatness based and backstepping controls in control the two-mass system is verified through comprehensive hardware-in-the-loop experiments and with the assumption of ideal stator current loop performance. Step-by-step control design procedures are given, in addition, system responses with classical PID control are also provided for parallel comparisons.
Sigmoid PID based adaptive safe experimentation dynamics algorithm of portable duodopa pump for Parkinson’s disease patients
Authors: Abdul Razak Ramesh Najwa Hidayah , Ghazali Mohd Riduwan , Ahmad Mohd Ashraf
Published: March 2021

This paper emphasizes on the development of an appropriate closed-loop control strategy for traditional portable duodopa pump (PDP); thereby ensuring an automated drug infusion without wearing off. In particular, a sigmoid proportional integral derivative (SPID) controller is adopted to control the blood plasma level of dopamine. The parameters of SPID controller are tuned using the adaptive safe experimentation dynamics (ASED) algorithm. The efficiency of the suggested SPID-ASED is evaluated by concerning the convergence plot of the cost function, the amount of dopamine in the blood plasma (BP) of the patient, the statistical analysis of cost function, norm of error and norm of input, and time responses specifications. The simulation results show that the proposed SPID-ASED outperforms the standard PID controller in terms of better control accuracy with minimum overshoot and settling time.
Mutual antenna coupling influence on the channel correlation matrix for linear antenna arrays
Authors: Artemova Tatiana K. , Gvozdarev Aleksey S. , Artemov Konstantin S.
Published: March 2021

The paper presents the results of the research of electromagnetic mutual coupling impact on the structure of the correlation matrices in multiantenna communication systems. Classical correlation structures employed in most of the up-to-date communication systems descriptions and designs usually assume unit autocorrelation and exponentially decreasing cross-correlation of antenna elements in the receiving/transmitting array. At the same time numerous studies had shown that these assumptions may not hold under certain conditions. The performed research relates the correlation effects with the imbalances of the array impedance matrix terms and studies the impact of antenna elements mutual electromagnetic interaction upon the diagonal (autocorrelation) and off-diagonal (cross-correlation) terms of correlation matrix, depending of the geometry of the array: number of elements and their spatial separation. To exemplify quantitative results the analysis was carried out for the 5G NR #78 band, being one of the most wideband subchannels in Under-6 GHz regime for 5G systems. The obtained results also justified the applicability of the banded correlation matrix model for wireless communications.
A cost-effective GPS-aided autonomous guided vehicle for global path planning
Authors: Akhshirsh Gorgees S. , Al-Salihi Nawzad K. , Hamid Oussama H.
Published: March 2021

This paper presents a robotic platform of a cost-effective GPS-aided autonomous guided vehicle (AGV) for global path planning. The platform is made of a mechanical radio controlled (RC) rover and an Arduino Uno microcontroller. An installed magnetic digital compass helps determine the right direction of the RC rover by continuously synchronising the heading and bearing of the vehicle. To ensure effective monitoring of the vehicle’s position as well as track the corresponding path, an LCD keypad shield was, further, used. The contribution of the work is that the designed GPS-aided AGV can successfully navigate its way towards a destination point in an obstacle-free outdoor environment by solely relying on its calculation of the shortest path and utilising the corresponding GPS data. This result is achieved with a minimum error possible that lies within a circle of one meter radius around the given destination, allowing the devised GPS-aided AGV to be used in a variety of applications such as landmine detection and removal.
State feedback linearization using block companion similarity transformation
Authors: Farida Kessal , Kamel Hariche , Hamid Bentarzi , Razika Boushaki
Published: March 2021

In this research work, a new method is proposed for linearizing a class of nonlinear multivariable system; where the number of inputs divides exactly the number of states. The idea of proposed method consists in representing the original nonlinear system into a state-dependent coefficient form and applying block similarity transformations that allow getting the linearized system in block companion form. Because the linearized system’s eigenstructure can determine system performance and robustness far more directly and explicitly than other indicators, the given class multivariable system is chosen. Examples are used to illustrate the application and show the effectiveness of the given approach.
ASSAS: An automatic smart students attendance system based on normalized cross-correlation
Authors: Al-Mallah Ruaa H. Ali , Alhelal Dheyaa , Abdulhammed Razan
Published: March 2021

A smart student attendance system (SSAS) is presented in this paper. The system is divided into two phases: hardware and software. The Hardware phase is implemented based on Arduino's camera while the software phase is achieved by using image processing with face recognition depended on the cross-correlation technique. In comparison with traditional attendance systems, roll call, and sign-in sheet, the proposed system is faster and more reliable (because there is no action needed by a human being who by its nature makes mistakes). At the same time, it is cheaper when compared with other automatic attendance systems. The proposed system provides a faster, cheaper and reachable system for an automatic smart student attendance that monitors and generates attendance report automatically.
A smart partial discharge classification SOM with optimized statistical transformation feature
Authors: Bohari Z. H. , Isa M. , Abdullah A. Z. , Soh P. J. , Sulaima M. F.
Published: March 2021

Condition-based monitoring (CBM) has been a vital engineering method to assess high voltage (HV) equipment and power cables conditions or health levels. One of the effective CBM methods is partial discharge (PD) measurement or detection. PD event is the phenomenon that always associated with insulation healthiness. PD has been measured and evaluated in this paper to discriminate PD signals from a good signal. A mixed-signal being fed at an AI technique with statistical modified input data to do fast classification (less than five seconds) with nearly zero error. In this paper, an unsupervised neural network is applied for PD classification. The methods combine the self-organizing maps (SOMs) and feature statistical transformation. By the combination of these methods, the ‘range’ normalization method produced the best classification outcomes. This development decided that PD information was effectively correlated and grouped by means of MATLAB’s SOM Toolbox and transformation device to discriminate the normal signal from the PD signal.
Optimization of triple-junction hydrogenated silicon solar cell nc-Si:H/a-Si:H/a-SiGe:H using step graded Si1‑xGex layer
Authors: Poespawati Nji Raden , Rahman Rizqy Pratama , Sulistianto Junivan , Wigajatri Purnamaningsih Retno , Abuzairi Tomy
Published: March 2021

This paper shows the attempt to increase the performance of triple-junction hydrogenated silicon solar cells with structure nc-Si:H/a-Si:H/a-SiGe:H. The wxAMPS software was used to simulate and optimize the design. In an attempt to increase the performance, an a-SiC:H layer on the p-layer was replaced with an a-Si:H layer and an a-SiGe layer was replaced with a step graded Si1-xGex layer. Then, to achieve the best performing device, we optimized the concentration of germanium and thickness of the step graded Si1-xGex layer. The result shows that the optimum concentration of germanium in the p-i upper layer and i-n lower layer are 0.86 and 0.90, respectively and the optimum thicknesses are 10 nm and 230 nm, respectively. The optimized device performed with an efficiency of 19.08%, adding 3 more percent of efficiency from the original design. Moreover, there is a significant possibility of increasing the efficiency of a triple-junction solar cell by modifying it into a step graded Si1-xGex layer.
Vietnamese character recognition based on CNN model with reduced character classes
Authors: Phan Thi Ha , Tran Duc Chung , Hassan Mohd Fadzil
Published: March 2021

This article will detail the steps to build and train the convolutional neural network (CNN) model for Vietnamese character recognition in educational books. Based on this model, a mobile application for extracting text content from images in Vietnamese textbooks was built using OpenCV and Canny edge detection algorithm. There are 178 characters classes in Vietnamese with accents. However, within the scope of Vietnamese character recognition in textbooks, some classes of characters only differ in terms of actual sizes, such as “c” and “C”, “o” and “O”. Therefore, the authors built the classification model for 138 Vietnamese character classes after filtering out similar character classes to increase the model's effectiveness.
Aspirações e fracassos da narrativa contemporânea em um romance de Roman Ehrlich
Authors: Pereira Valéria Sabrina
Published: March 2021

Em seu último romance, Die fürchterlichen Tage des schrecklichen Grauens (Os pavorosos dias do Espantoso Horror), Roman Ehrlich apresenta a trajetória de um grupo de pessoas que almeja produzir um filme de terror inovador que retrate todos os medos da atualidade. Ao mesmo tempo que não rejeitam a inspiração dos mais diversos filmes do gênero, incluindo o trash, os envolvidos acreditam poder produzir uma obra vanguardista de destacada qualidade artística. Tão claro quanto o futuro fracasso do projeto, está o jogo de vaidades e inseguranças que movimenta o grupo, assim como a completa ausência das pretensas qualidades artísticas. Com base nas teorias de Andreas Huyssen sobre o pós-moderno, Bourdieu sobre o valor da arte, e Boris Groys sobre o novo, este artigo visa discutir como ambições artísticas mal fundamentadas produzem o efeito de vazio trabalhado no romance de Roman Ehrlich.
O caso Marpurg-Couperin: apropriação pela via da tradução e consequente autoria
Authors: Paschoal Stéfano
Published: March 2021

Este trabalho tem como objetivo discutir as noções de apropriação pela via da tradução a partir da análise de oito excertos da Preparação à primeira parte da obra Die Kunst das Clavier zu spielen de Friedrich Wilhelm Marpurg. A Preparação desta obra compõe-se de 23 parágrafos, dos quais oito refletem ideias apresentadas numa obra anterior, a saber, L’Art de toucher le clavecin (1716), de François Couperin. Para este trabalho será considerado o reflexo dessas ideias pela via da tradução. Os trechos traduzidos aparecem ora aumentados, ora reduzidos, ou então são suprimidos. Esta dinâmica de tradução é afirmada por Marpurg no prefácio de duas edições anteriores a 1762: as edições de 1750 e 1751. Investigamos, nas discussões sobre apropriação, o que teria levado Marpurg a abandonar a reverência a Couperin nos prefácios de edições posteriores, o que contribuiu para que essa apropriação – ocorrida também, mas não apenas por meio da tradução – pudesse ser relacionada, a princípio, à autoria. Nesse sentido, apoiados em obras científicas sobre tradução e apropriação, discutimos a noção de tradução, apropriação e autoria, traçando um diálogo com duas áreas dos Estudos da Tradução: análise comparativa e tradução comentada.
Cultura material e pesquisa museológica: um estudo relacionado ao patrimônio cultural de ciência e tecnologia no Museu da Geodiversidade (IGEO-UFRJ)
Authors: Albuquerque Geórgia Raisa Ramos de , Ferreira Luiz Felipe Lima , Castro Aline Rocha de Souza Ferreira de
Published: March 2021

Este trabalho apresenta, a partir da pesquisa museológica, a história da construção do conhecimento científico produzido pela Universidade Federal do Rio de Janeiro (UFRJ), através de objetos encontrados nos laboratórios do Instituto de Geociências (IGeo). Para tanto, o Museu da Geodiversidade (IGeo–UFRJ) por meio do projeto “Objetos de ciência e tecnologia do Instituto de Geociências (IGeo) da Universidade Federal do Rio de Janeiro: pesquisa e identificação de um patrimônio a ser descoberto”, propôs uma pesquisa para levantar, catalogar e preservar objetos e instrumentos científicos e didáticos que ajudaram na produção e divulgação do conhecimento acadêmico. A pesquisa levantou, até o momento, informações sobre 164 itens, dentre os quais dois objetos distintos destacaram-se durante as atividades:um barógrafo centenário, modelo Anciennes Maison Richard Frères Jules Richard, doação do professor José Marques do Departamento de Meteorologia UFRJ, o objeto mais antigo da coleção; e uma balança eletrônica de sedimentação Sartorius, adquirida pelo Instituto de Geociências em 1970, sendo o elemento mais bem documentado até então. Apesar da relevância que a pesquisa revelou, esse patrimônio necessita de maior atenção por parte da instituição, que deve assegurar um local de guarda adequado, além de incentivos para que a pesquisa continue, pois muitos outros objetospodem se destacar no conjunto já levantado. Verificamos que o projeto de pesquisa foi fundamental para essas descobertas que possibilitarão a preservação da memória institucional e a musealização dessa parte do patrimônio cultural de ciência e tecnologia da UFRJ.
Exercícios museais com o patrimônio universitário da UFRGS: ações em prol da preservação e divulgação de acervos de caráter museológico
Authors: Faria Ana Carolina Gelmini de , Silva Ana Celina Figueira da , Gomes Diogo Santos
Published: March 2021

A Universidade Federal do Rio Grande do Sul (UFRGS) tem sua história iniciada em 1895, com a fundação dos que viriam a ser seus primeiros cursos, e é formulada enquanto universidade em 1934, com o nome de Universidade de Porto Alegre. Sua federalização ocorreu em 1950, passando à esfera administrativa da União. Se considerarmos a data de fundação das primeiras formações, temos 125 anos de história da educação no sul do Brasil. Essa trajetória se faz presente em documentos escritos, mas também na cultura material vinculada à UFRGS. Como pensar a preservação, pesquisa e promoção dos objetos que evocam essa história? A formação em Museologia da UFRGS tem buscado estratégias de gestão desse acervo, bem como de difusão do conhecimento produzido a partir dessas evidências materiais móveis. No artigo, três experiências são compartilhadas – o programa de extensão “Museologia na UFRGS: trajetórias e memórias”; o projeto “Gestão de acervos museológicos da UFRGS”; a disciplina eletiva “Tópicos especiais em pesquisa museológica da graduação em Museologia” – para refletirmos sobre a musealidade dos acervos que podem vir a se tornar museálias em salvaguarda da Universidade. Observou-se que a Universidade possui um vasto patrimônio cultural sob sua tutela, mas há ainda um longo processo museal para se tornarem museálias. Conclui-se que há a necessidade de interlocução e articulação entre as áreas do conhecimento, bem como a construção e consolidação de políticas setoriais para a difusão da produção científica e cultural presente na UFRGS por meio de seu patrimônio cultural universitário móvel.
Experimentações sociotécnicas para organização e difusão de coleções digitais universitárias: o caso do projeto Tainacan
Authors: Martins Luciana Conrado , Martins Dalton Lopes
Published: March 2021

O artigo busca evidenciar como o uso das tecnologias digitais facilita a organização e o acesso às coleções e aos museus universitários. Por meio da análise dos casos de universidades que utilizam o software Tainacan como repositório digital de acervos, foram evidenciadas e discutidas as práticas de apropriação das ferramentas digitais por essas instituições e os ganhos advindos desse uso frente aos desafios de controle e socialização da informação presentes na área. Para isso, foi realizado um estudo quantitativo que buscou levantar o número de itens catalogados nos repositórios e que foram posteriormente analisados levando-se em consideração sua distribuição de frequência nas categorias analíticas  propostas. Ressaltou-se os diferentes usos sociotécnicos e as formas específicas de apropriação, destacando-se as práticas de gestão e tratamento da informação a serem estudadas. Foram identificadas 17 instituições universitárias do Brasil e do exterior com experiências na organização de 63 coleções digitais, que contabilizaram um total de 11.896 catalogados. Os resultados permitem levantar a hipótese de que a adoção do Tainacan pelos museus e coleçõesuniversitárias está relacionado à flexibilidade e à facilidade de uso da ferramenta, que consegue atender a enorme diversidade tipológica, de filiação institucional desses acervos e maior simplicidade na implantação e customização. Além disso, percebe-se que o Tainacan possibilita o exercício da convergência digital em relação às coleções universitárias, aproximando esses acervos de uma maior mobilidade e possibilidade de comunicação com a sociedade, constituindo-se como uma importante solução para a socialização desses acervos.
A transversalidade no ensino da preservação e conservação de bens culturais no curso de graduação em museologia da UFOP e sua associação com o museu universitário e a cidade patrimônio
Authors: Gomes Gabriela de Lima , Rezende Edson Fialho de
Published: March 2021

Este artigo é um relato sobre experiências vivenciadas no curso de graduação em Museologia da Universidade Federal de Ouro Preto (UFOP), com foco naquelas que abrangem a área da preservação e conservação de acervos museológicos. Para tanto, partimos da implantação do primeiro curso de graduação em Museologia no estado de Minas Gerais para, posteriormente, discutir os posicionamentos que direcionaram a elaboração metodológica das disciplinas de Documentação Fotográfica e Preservação Digital e de Preservação e Conservação de Bens Culturais, que reconhecemas relações entre a produção da paisagem cultural e o patrimônio museológico universitário. O relato é ampliado a partir do contexto histórico de criação do Museu de Ciência e Técnica da Escola de Minas (enquanto um museu universitário) e sua oferta de parceria com o Departamento de Museologia, por meio do Laboratório de Conservação e Restauro em nome de garantir a qualidade do processo de ensino-aprendizagem e a troca de experiências acadêmicas. Concluímos, assim, que a prática laboratorial dos discentes durante a graduação é indispensável e que o exercício em um espaço (próximo do) ideal contribui para reflexões importantes sobre a gestão do patrimônio universitário.
Propostas de professores para visitas escolares a um museu de zoologia no contexto da alfabetização científica
Authors: Pugliese Adriana , Silva João Rodrigo Santos da , Binder Nathalia , Sessa Patricia da Silva
Published: March 2021

O presente artigo tem como foco a aproximação entre os espaços educativos não formais, como um museu, e as demandas da educação escolar e suas possibilidades propostas por professores da Educação Básica no contexto do processo de alfabetização científica. A pesquisa tem como objetivo descrever como os professores se apropriam dos objetos expositivos do Museu de Zoologia da Universidade de São Paulo ao criarem roteiros de visitação para este espaço. A partir disso, configuramos as seguintes questões: como os professores estabelecem relações entre os conteúdos e temas para trabalhar a parceria entre a escola e o museu? Quais aparatos estabelecem as maiores relações dialógicas de conhecimento escolar e museal com base nas propostas de ações dos professores? E como essaspropostas de roteiros de visita se relacionam com os eixos estruturantes de alfabetização científica? No tocante ao desenho metodológico, o presente trabalho tem um caráter descritivo e qualitativo, com base na análise de conteúdo. Em termos conclusivos, pode-se sinalizar não só os aparatos mais atrativos da exposição, como indicar aqueles que podem ganhar destaque para, futuramente, serem utilizados nas visitas escolares. Observa-se ainda que à luz da alfabetização científica evidenciada nos roteiros elaborados, há maior preocupação com a apropriação dos termos e dos conceitos próprios da ciência e por outro lado, uma menor abordagem com as relações entre a natureza da ciência e suas práticas.
O uso da tipografia em exposições museológicas: reflexões e experiências de visita em dois museus da USP
Authors: Camargo Iara Pierro de , Figueiredo-Lanz Renata Dias de Gouvea de
Published: March 2021

Os textos apresentados em exposições museológicas são uma importante ferramenta de comunicação entre seus criadores e os visitantes. Mesmo diante do crescimento da espetacularização midiática em museus, os textos ainda são grandes protagonistas no desenvolvimento da narrativa expográfica e, portanto, na compreensão da exposição. Entretanto as referências bibliográficas sobre expografia dificilmente mencionam a tipografia e sua relação com o visitante dos museus. Por essa razão este artigo aborda o uso da tipografia em exposições museológicas como uma reflexão sobre as experiências da leitura em exposições de longa duração em dois museus de ciências da Universidade de São Paulo: o Museu de Zoologia e o Museu de Anatomia Veterinária. Como metodologia de pesquisa, realizaram-se visitas a essas exposições e, com embasamento nos autores das áreas de expografia, tipografia e sinalização, analisaram-se as tipografias empregadas. A partir da definição da legibilidade da fonte tipográfica, foram analisados os desafios espaciais da exposição – e dos seus suportes – para a leitura dos textos, bem como as dificuldades impostas aos  visitantes não inerentes ao espaço da exposição, mas à própria natureza do visitante e a sua relação com os outros indivíduos presentes no espaço expositivo.
Antecedentes para a visitação de eventos culturais no bairro do Recife
Authors: Queiroz Alessandra Souza , Costa Marconi Freitas da , Guerra José Roberto Ferreira
Published: March 2021

Essa investigação teve o propósito de mensurar qual influência os grupos de referência (GDR), a sensibilidade ao preço (SAP) e a identificação (I) poderiam exercer sobre a intenção de visitar eventos culturais em espaços públicos do Bairro do Recife. Como estratégia de pesquisa foi utilizado o survey online. Um questionário estruturado foi desenvolvido, obtendo 116 respondentes, todos considerados válidos para a amostra final. Os dados foram analisados com base na análise de regressão linear múltipla. Assim, os construtos de identificação (I) e grupos de referência (GDR) influenciam positivamente na decisão de visitar eventos culturais em espaços públicos, já o construto de sensibilidade à preço (SAP) não exerce influência alguma sobre a VD intenção de visitar eventos culturais em espaços públicos do Bairro do Recife. As características do público que frequenta o Bairro do Recife, não são influenciadas por aspectos financeiros, são influenciadas por grupos de referência e pela identificação com a localidade. A relevância desse trabalho se encontra em sua originalidade a temática.
Petrografia, geoquímica e proveniência da Formação Corumbataí aflorante no município de Mineiros (GO)
Authors: Montibeller Cibele Carolina , Navarro Guillermo Rafael Beltran , Zanardo Antenor
Published: March 2021

No estado de Goiás, ocorrem litotipos similares àqueles atribuídos à Formação Corumbataí, no estado de São Paulo, embora a escassez de bibliografias específicas sobre a unidade na Região Centro-Oeste brasileira e a ausência de mapeamentos de detalhe nas adjacências da Serra do Caiapó (centro-sudeste do estado de Goiás) suscitem dúvidas quanto à correlação entre essas áreas de afloramento de unidades permianas e aquelas encontradas no domínio paulista da Bacia do Paraná. Sendo assim, este trabalho apresenta caraterísticas mineralógicas, petrográficas e geoquímicas da Formação Corumbataí no estado de Goiás, bem como suas implicações de proveniência, intemperismo e paleoclima, no intuito de fornecer dados complementares que permitam estabelecer correlações entre as diversas áreas aflorantes da unidade ao longo das bordas norte e leste da bacia. Os siltitos do município de Mineiros (GO) são quimicamente classificados, predominantemente, como “wackes” e arcósios, e, secundariamente, como litoarenitos e sublitoarenitos, com alta maturidade textural e maturidade química variável, gerados por sedimentos provenientes principalmente de rochas sedimentares quartzosas, com menores contribuições de rochas ígneas félsicas e máficas. Aparentemente, esses sedimentos sofreram pouco efeito de reciclagem sedimentar, advogando por uma maior proximidade das áreas-fonte, sendo que esta foi submetida a variados graus de intemperismo, o que sugere mistura de diversas fontes na geração dos sedimentos que deram origem à unidade, além de haver predomínio de classificação das fontes como derivadas de regiões tectonicamente ativas ou arcos de ilha continentais.
Novel Trial Design: CHIEF-HF
Authors: Spertus John A. , Birmingham Mary C. , Butler Javed , Lingvay Ildiko , Lanfear David E. , Abbate Antonio , Kosiborod Mikhail N. , Fawcett Christina , Burton Paul , Damaraju C.V. , Januzzi James L. , Whang John
Published: March 2021

Background:

The expense of clinical trials mandates new strategies to efficiently generate evidence and test novel therapies. In this context, we designed a decentralized, patient-centered randomized clinical trial leveraging mobile technologies, rather than in-person site visits, to test the efficacy of 12 weeks of canagliflozin for the treatment of heart failure, regardless of ejection fraction or diabetes status, on the reduction of heart failure symptoms.

Methods:

One thousand nine hundred patients will be enrolled with a medical record-confirmed diagnosis of heart failure, stratified by reduced (≤40%) or preserved (>40%) ejection fraction and randomized 1:1 to 100 mg daily of canagliflozin or matching placebo. The primary outcome will be the 12-week change in the total symptom score of the Kansas City Cardiomyopathy Questionnaire. Secondary outcomes will be daily step count and other scales of the Kansas City Cardiomyopathy Questionnaire.

Results:

The trial is currently enrolling, even in the era of the coronavirus disease 2019 (COVID-19) pandemic.

Conclusions:

CHIEF-HF (Canagliflozin: Impact on Health Status, Quality of Life and Functional Status in Heart Failure) is deploying a novel model of conducting a decentralized, patient-centered, randomized clinical trial for a new indication for canagliflozin to improve the symptoms of patients with heart failure. It can model a new method for more cost-effectively testing the efficacy of treatments using mobile technologies with patient-reported outcomes as the primary clinical end point of the trial.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT04252287.
Myocardial Fibrosis in Pediatric Patients With Ebstein’s Anomaly
Authors: Aly Safwat , Seed Mike , Yoo Shi-Joon , Lam Christopher , Grosse-Wortmann Lars
Published: March 2021

Background:

Left ventricular dysfunction in Ebstein’s anomaly (EA) is associated with higher mortality. The health of the left ventricular myocardium in children and adolescents with EA has not been investigated in detail.

Methods:

Patients with unrepaired EA who had undergone cardiac magnetic resonance imaging including T1 mapping were retrospectively reviewed. Patients were compared with age- and sex-matched controls. EA severity index was calculated using volumetric measurements at end diastole ([right atrial+atrialized right ventricular volumes]/[functional right ventricular+left atrial+left ventricular volumes]). Global circumferential and radial strain and as well as strain rate were examined using cardiac magnetic resonance feature tracking.

Results:

Twelve EA patients and an equal number of controls were included. Functional and atrialized right ventricular end-diastolic volumes were 84±15 and 21±13 mL/m
2
, respectively. Late gadolinium enhancement, confined to the right ventricle, was found in 2 patients (16%). Left ventricular native T1 values and extracellular volume fractions were higher in patients compared with controls (1026±47 versus 956±40 ms,
P
=0.0004 and 28.5±3.4% versus 22.5±2.6%,
P
<0.001, respectively). Native T1 times correlated inversely with patients’ age, body surface area, and O
2
saturations (r=−0.63, −0.62, and −0.91, respectively;
P
=0.02,
P
=0.02, and
P
<0.0001, respectively). EA severity index ranged between 0.15 and 0.94 and correlated with T1 values (r=0.76,
P
=0.003). Native T1 correlated with global circumferential strain (r=0.58,
P
=0.04) but not ejection fraction (EF). EA patients had reduced maximum oxygen uptake (V
o
2
max). V
o
2
max correlated inversely with T1 values (r=−0.79,
P
=0.01).

Conclusions:

Children and adolescents with EA experience an abnormal degree of diffuse myocardial fibrosis. Its association with O
2
saturation points toward a role of hypoxemia in the pathogenesis of fibrosis. Larger and prospective studies are needed to evaluate the value of T1 mapping for risk stratification and monitoring in EA.
Clopidogrel Versus Ticagrelor or Prasugrel After Primary Percutaneous Coronary Intervention According to CYP2C19 Genotype
Authors: Claassens Daniel M.F. , Bergmeijer Thomas O. , Vos Gerrit J.A. , Hermanides Renicus S. , van ’t Hof Arnoud W.J. , van der Harst Pim , Barbato Emanuele , Morisco Carmine , Tjon Joe Gin Richard M. , Asselbergs Folkert W. , Mosterd Arend , Herrman Jean-Paul R. , Dewilde Willem J.M. , Janssen Paul W.A. , Kelder Johannes C. , Mahmoodi Bakhtawar K. , Deneer Vera H.M. , ten Berg Jurriën M.
Published: March 2021

Background:

Guidelines favor ticagrelor or prasugrel over clopidogrel in patients with myocardial infarction. However, the POPular Genetics trial (Patient Outcome After Primary Percutaneous Coronary Intervention [PCI]) showed that in patients with primary PCI, a
CYP2C19
genotype–guided strategy was associated with a lower bleeding risk without increasing thrombotic risk, compared with routine ticagrelor/prasugrel treatment. Nevertheless, optimal P2Y
12
inhibitor treatment in specific
CYP2C19
genetic subgroups is still a subject of debate.

Methods:

A prespecified subanalysis of the POPular Genetics trial was performed, using patients in whom
CYP2C19
*2, *3, and *17 genotypes was determined. Two different analyses were planned. The first assessed the effect of the
CYP2C19
*17 allele in clopidogrel-treated patients. The second compared the effect of clopidogrel in noncarriers of a loss-of-function allele with ticagrelor/prasugrel–treated patients, irrespective of
CYP2C19
genotype. Main outcomes were a thrombotic outcome (cardiovascular death, myocardial infarction, stent thrombosis, and stroke) and a bleeding outcome (PLATO [Platelet Inhibition and Patient Outcomes] major and minor bleeding) after 12 months.

Results:

A total of 2429 patients were used for analyses. In the first analysis, the
CYP2C19
*17 polymorphism was not found to have a significant influence on thrombotic (adjusted hazard ratio, 0.95 [95% CI, 0.45–2.02]) or bleeding outcomes (adjusted hazard ratio, 0.74 [95% CI, 0.48–1.18]). In the second analysis, clopidogrel was associated with a lower number of bleeding events compared with ticagrelor/prasugrel (9.9% versus 11.7%, adjusted hazard ratio, 0.74 [95% CI, 0.56–0.96]), without a significant increase in thrombotic events (3.4% versus 2.5%, adjusted hazard ratio, 1.14 [95% CI, 0.68–1.90]).

Conclusions:

In patients with primary PCI not carrying a
CYP2C19
loss-of-function allele, the use of clopidogrel compared with ticagrelor or prasugrel was associated with lower bleeding rates, without an increase in thrombotic events. No effect on clinical outcomes was found for the
CYP2C19
*17 polymorphism.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01761786. URL:
https://www.trialregister.nl/
; Unique identifier: NL2872.