bluuebunny/crossref_metadata_2025 huggingface dataset:
Patient-Specific Dosimetry Evaluations in Theranostics Software for Internal Radiotherapy
Authors: Grassi Elisa , Finocchiaro Domenico , Fioroni Federica , Andl George , Filice Angelina , Versari Annibale , El Ouati Ayman , Spezi Emiliano , Iori Mauro
Published: August 2024

In Internal Radiotherapy, radiopharmaceutical dosimetry provides an accurate estimation of absorbed radiation doses to organs at risk and tumours. In this paper Velocity Theranostics (Varian Medical Systems), is investigated. Its performances are compared to OLINDA 2.0 in both an anthropomorphic phantom and a group of patients. Velocity Theranostics was evaluated with a cohort of patients (15) treated with 177Lu radiolabelled peptides. The absorbed doses were calculated for the liver, spleen and kidneys, separately with OLINDA 2.0 and Velocity Theranostics using the same set of images. To reduce the contribution of Time-integrated activities (TIAs) on the results and to merely compare the dose calculation algorithms, the OLINDA 2.0 absorbed doses were calculated using the TIA values calculated in Velocity Theranostics. The absorbed doses from Velocity Theranostics were found to be correlated with the doses from OLINDA 2.0 with the TIAs from Theranostics (Lin’s coefficient = 0.894 and R2 = 0.9531). Absorbed doses from Velocity Theranostics are reliable at least as reliable as those for OLINDA 2.0, with many advantages regarding accuracy of calculations and robustness. In conclusion, the personalisation of dosimetry may be totally fulfilled by computational systems for absorbed dose in internal radiotherapy, equipped with a complete workflow and borrowed from external radiotherapy.
An Interseasonal Comparison of Soil Respiration in Xeric and Mesic Pine Forest Ecosystems in Central Siberia
Authors: Makhnykina Anastasia , Vaganov Eugene , Panov Alexey , Polosukhina Daria , Prokushkin Anatoly
Published: August 2024

An understanding of how boreal forest composition responds to global environmental changes is an important challenge to predicting the future global carbon balance. Boreal forests are the most significant sink for atmospheric carbon dioxide; however, their sequestration capacity is highly sensitive to ongoing climate changes. The combination of the hydrothermal conditions of a territory strongly regulates its biogeochemical processes. The carbon fluxes in boreal forests are strongly mediated by the ground vegetation cover, composed of mosses (mesic) and lichens (xeric). Despite the concurrence of xeric and mesic vegetation types, their responses to climate variations varies significantly. Soil emission is an informative indicator of ecosystem functioning. In this study, we focused on the soil CO2 dynamics during frost-free seasons with different precipitation regimes in the xeric and mesic boreal ecosystems of Central Siberia. Seasonal measurements of soil CO2 emissions were conducted during frost-free seasons using the dynamic chamber method. Our findings reveal that the precipitation regimes of each year may control the seasonal soil emission dynamics. The soil moisture is the most important driver of emissions growth in the water-limited lichen pine forest (R2adj. = 18%). The soil temperature plays the largest role in the feather moss pine forest during the dry (R2adj. = 31%) seasons, and in the lichen pine forest during the wet (R2adj. = 41%) seasons. The cumulative efflux for the xeric and mesic sites is mostly related to the hydrothermal conditions, and not to the differences in ground vegetation cover. During the dry seasons, on average, the soil CO2 emissions are 45% lower than during the wet seasons for both sites. These findings emphasize the need for estimating and including the hydrothermal characteristics of the growing season for detailed emission assessments.
Recent Advances in SCR Systems of Heavy-Duty Diesel Vehicles—Low-Temperature NOx Reduction Technology and Combination of SCR with Remote OBD
Authors: Chen Zhengguo , Liu Qingyang , Liu Haoye , Wang Tianyou
Published: August 2024

Heavy-duty diesel vehicles are a significant source of nitrogen oxides (NOx) in the atmosphere. The Selective Catalytic Reduction (SCR) system is a primary aftertreatment device for reducing NOx emissions from heavy-duty diesel vehicles. With increasingly stringent NOx emission regulations for heavy-duty vehicles in major countries, there is a growing focus on reducing NOx emissions under low exhaust temperature conditions, as well as monitoring the conversion efficiency of the SCR system over its entire lifecycle. By reviewing relevant literature mainly from the past five years, this paper reviews the development trends and related research results of SCR technology, focusing on two main aspects: low-temperature NOx reduction technology and the combination of SCR systems with remote On-Board Diagnostics (OBD). Regarding low-temperature NOx reduction technology, the results of the review indicate that the combination of multiple catalytic shows potential for achieving high conversion efficiency across a wide temperature range; advanced SCR system arrangement can accelerate the increase in exhaust temperature within the SCR system; solid ammonium and gaseous reductants can effectively address the issue of urea not being able to be injected under low-temperature exhaust conditions. As for the combination of SCR systems with remote OBD, remote OBD can accurately assess NOx emissions from heavy-duty vehicles, but it needs algorithms to correct data and match the emission testing process required by regulations. Remote OBD systems are crucial for detecting SCR tampering, but algorithms must be developed to balance accuracy with computational efficiency. This review provides updated information on the current research status and development directions in SCR technologies, offering valuable insights for future research into advanced SCR systems.
The Assessment of Precipitation and Droughts in the Aegean Region Using Stochastic Time Series and Standardized Precipitation Index
Authors: Tanrıkulu Ahmet , Guner Ulker , Bahar Ersin
Published: August 2024

This study analyzes drought conditions in the Aegean region using monthly precipitation data from nine stations between 1972 and 2020. The Standardized Precipitation Index (SPI) was calculated for 1-, 3-, 6-, 9-, and 12-month periods to evaluate drought conditions at different timescales and station-specific conditions. The results indicate that short-term droughts are more frequent but shorter in duration, while longer periods exhibit fewer but more prolonged droughts. The relative frequency of drought across all periods ranges between 9% and 27%. The İzmir and Denizli stations were highlighted due to their representation of coastal and inner regions, respectively. The findings show that coastal stations, like İzmir, experience more frequent wet years compared to inner stations like Denizli, which have more dry years. Time series linear autoregressive (AR) models, using SPI-12 data, were developed to represent long-term drought trends and forecasts. The best-fitting models were determined using AIC, AICC, FPE, and Var(e) criteria, with AR(2) generally being the most suitable, except for Denizli. This integrated analysis of SPI and AR models provides a robust basis for understanding regional precipitation regimes and predicting future droughts, aiding in the development of effective drought mitigation strategies and water resource management. Future research is anticipated to extend this analysis to encompass all of Turkey and explore various time series models’ applicability.
The Long-Term Monitoring of Atmospheric Polychlorinated Dibenzo-p-Dioxin Dibenzofurans at a Background Station in Taiwan during Biomass Burning Seasons in El Niño and La Niña Events
Authors: Pan Shih Yu , Hsu Yen-Shun , Hsu Yuan Cheng , Ngo Tuan Hung , Chou Charles C.-K. , Lin Neng-Huei , Chi Kai Hsien
Published: August 2024

To measure the long-range transport of PCDD/Fs, a background sampling site at Mt. Lulin station (Taiwan) was selected based on meteorological information and its location relative to burning events in Southeast Asia. During regular sampling periods, a higher concentration of PCDD/Fs was recorded in 2008 at Mt. Lulin station during La Niña events, with levels reaching 390 fg I-TEQ/m3. In contrast, a higher concentration of 483 fg I-TEQ/m3 was observed in 2013 during biomass burning events. This indicates that La Niña affects the ambient PCDD/F concentrations. The ratio of ΣPCDD/ΣPCDF was 0.59, suggesting significant long-range transport contributions from 2007 to 2023. From 2007 to 2015, the predominant species was 2,3,4,7,8-PCDF, accounting for 25.3 to 39.6% of the total PCDD/Fs. From 2018 onward, 1,2,3,7,8-PCDD became more dominant, accounting for 15.0 to 27.1%. According to the results from the receptor model PMF (n = 150), the sources of PCDD/Fs were identified as dust storms and monsoon events (19.3%), anthropogenic activity (28.5%), and biomass burning events (52.2%). The PSCF values higher than 0.7 highlighted potential PCDD/F emission source regions for Mt. Lulin during biomass burning events, indicating high PSCF values in southern Thailand, Cambodia, and southern Vietnam.
Outcome of Primary Stapedotomy in 21 Consecutive Cases of Juvenile Otosclerosis
Authors: Gambacorta Valeria , Stivalini Davide , Lupinelli Giacomo , Faralli Mario , Orzan Eva , Ricci Giampietro
Published: August 2024

Background/Objectives: Otosclerosis is a relatively uncommon condition that causes conductive hearing loss in children. The preferred treatment for adults is stapedotomy, while for individuals under 18 years old, there is an ongoing discussion about the best treatment approach. Thus, the surgical procedure for the stapes in pediatric patients continues to be a subject of debate. This study aimed to evaluate the results of stapes surgery in children, trying to understand, based on our results, whether this is actually the most suitable option. Methods: The study included 18 patients who underwent surgery between January 2013 and December 2023. The patients’ ages ranged from 11 to 18 years, with an average age of 14.7. Out of the total 21 surgeries, three patients opted for bilateral surgery. Pre- and post-operative data were compared, focusing on the mean air conduction (AC) and bone conduction (BC) thresholds at frequencies of 0.5, 1, 2, and 4 kHz. Additionally, pre-operative thresholds and the post-operative air–bone gap (ABG) were examined. Results: After a year, the air–bone gap was effectively reduced to 10 dB or less in 94% of the 21 cases, and to 20 dB or less in 98% of all cases. Conclusions: Our results and research in the field have consistently shown that stapedotomy, when conducted by skilled otosurgeons, is a reliable and successful procedure for a considerable number of patients. The outcomes it generates are similar to those achieved through the procedure conducted during adulthood.
Deep Learning Regression with Sequences of Different Length: An Application for State of Health Trajectory Prediction and Remaining Useful Life Estimation in Lithium-Ion Batteries
Authors: Bellomo Michele , Giazitzis Spyridon , Badha Susheel , Rosetti Filippo , Dolara Alberto , Ogliari Emanuele
Published: August 2024

This study presents methods to handle deep learning regressions with input and output sequences of different lengths. We discuss the Autoregressive one-step prediction framework and introduce an innovative one-time multi-step (OTMS) prediction approach, based on a custom loss function, that predicts all future steps in a single shot. The presented methodologies are then applied to simultaneously predict the State of Health (SoH) trajectory and estimate the Remaining Useful Life (RUL) of lithium-ion battery cells. Accurate estimates of SoH trajectory and RUL are essential for Battery Management Systems (BMSs), electronic systems that guarantee safety while maximizing performance and extending battery lifespan. In this context, the studied methodologies were compared using a rigorous cross-validation approach. The OTMS model showed better predictions in early cycles, while the Autoregressive model performed better in later cycles, suggesting a hybrid approach between these two methodologies as an optimal solution.
3D Quantitative-Amplified Magnetic Resonance Imaging (3D q-aMRI)
Authors: Terem Itamar , Younes Kyan , Wang Nan , Condron Paul , Abderezaei Javid , Kumar Haribalan , Vossler Hillary , Kwon Eryn , Kurt Mehmet , Mormino Elizabeth , Holdsworth Samantha , Setsompop Kawin
Published: August 2024

Amplified MRI (aMRI) is a promising new technique that can visualize pulsatile brain tissue motion by amplifying sub-voxel motion in cine MRI data, but it lacks the ability to quantify the sub-voxel motion field in physical units. Here, we introduce a novel post-processing algorithm called 3D quantitative amplified MRI (3D q-aMRI). This algorithm enables the visualization and quantification of pulsatile brain motion. 3D q-aMRI was validated and optimized on a 3D digital phantom and was applied in vivo on healthy volunteers for its ability to accurately measure brain parenchyma and CSF voxel displacement. Simulation results show that 3D q-aMRI can accurately quantify sub-voxel motions in the order of 0.01 of a voxel size. The algorithm hyperparameters were optimized and tested on in vivo data. The repeatability and reproducibility of 3D q-aMRI were shown on six healthy volunteers. The voxel displacement field extracted by 3D q-aMRI is highly correlated with the displacement measurements estimated by phase contrast (PC) MRI. In addition, the voxel displacement profile through the cerebral aqueduct resembled the CSF flow profile reported in previous literature. Differences in brain motion was observed in patients with dementia compared with age-matched healthy controls. In summary, 3D q-aMRI is a promising new technique that can both visualize and quantify pulsatile brain motion. Its ability to accurately quantify sub-voxel motion in physical units holds potential for the assessment of pulsatile brain motion as well as the indirect assessment of CSF homeostasis. While further research is warranted, 3D q-aMRI may provide important diagnostic information for neurological disorders such as Alzheimer’s disease.
Assessment of Extracellular Matrix Fibrous Elements in Male Dermal Aging: A Ten-Year Follow-Up Preliminary Case Study
Authors: Machaliński Bogusław , Oszutowska-Mazurek Dorota , Mazurek Przemyslaw , Parafiniuk Mirosław , Szumilas Paweł , Zawiślak Alicja , Zaremba Małgorzata , Stecewicz Iwona , Zawodny Piotr , Wiszniewska Barbara
Published: August 2024

Skin aging is a complex phenomenon influenced by multiple internal and external factors that can lead to significant changes in skin structure, particularly the degradation of key extracellular matrix (ECM) components such as collagen and elastic fibers in the dermis. In this study, we aimed to meticulously assess the morphological changes within these critical fibrous ECM elements in the dermis of the same volunteer at age 47 and 10 years later (2012 to 2022). Using advanced histological staining techniques, we examined the distribution and characteristics of ECM components, including type I collagen, type III collagen, and elastic fibers. Morphological analysis, facilitated by hematoxylin and eosin staining, allowed for an accurate assessment of fiber bundle thickness and a quantification of collagen and elastic fiber areas. In addition, we used the generalized Pareto distribution for histogram modeling to refine our statistical analyses. This research represents a pioneering effort to examine changes in ECM fiber material, specifically within the male dermis over a decade-long period. Our findings reveal substantial changes in the organization of type I collagen within the ECM, providing insight into the dynamic processes underlying skin aging.
Ablation of TrkB from Enkephalinergic Precursor-Derived Cerebellar Granule Cells Generates Ataxia
Authors: Eliseeva Elena , Malik Mohd Yaseen , Minichiello Liliana
Published: August 2024

In ataxia disorders, motor incoordination (ataxia) is primarily linked to the dysfunction and degeneration of cerebellar Purkinje cells (PCs). In spinocerebellar ataxia 6 (SCA6), for example, decreased BDNF–TrkB signalling appears to contribute to PC dysfunction and ataxia. However, abnormal BDNF–TrkB signalling in granule cells (GCs) may contribute to PC dysfunction and incoordination in ataxia disorders, as TrkB receptors are also present in GCs that provide extensive input to PCs. This study investigated whether dysfunctional BDNF–TrkB signalling restricted to a specific subset of cerebellar GCs can generate ataxia in mice. To address this question, our research focused on TrkbPenk-KO mice, in which the TrkB receptor was removed from enkephalinergic precursor-derived cerebellar GCs. We found that deleting Ntrk2, encoding the TrkB receptor, eventually interfered with PC function, leading to ataxia symptoms in the TrkbPenk-KO mice without affecting their cerebellar morphology or levels of selected synaptic markers. These findings suggest that dysfunctional BDNF–TrkB signalling in a subset of cerebellar GCs alone is sufficient to trigger ataxia symptoms and may contribute to motor incoordination in disorders like SCA6.
Molecular Aspects of Cardiovascular Risk Factors
Authors: Xu Shang-Zhong , Sathyapalan Thozhukat
Published: August 2024

Cardiovascular diseases (CVDs) are the leading cause of death [...]
Correction: Thangameeran et al. Examining Transcriptomic Alterations in Rat Models of Intracerebral Hemorrhage and Severe Intracerebral Hemorrhage. Biomolecules 2024, 14, 678
Authors: Thangameeran Shaik Ismail Mohammed , Tsai Sheng-Tzung , Liew Hock-Kean , Pang Cheng-Yoong
Published: August 2024

In the original publication [...]
Gas Chromatography–Mass Spectrometry-Based Analyses of Fecal Short-Chain Fatty Acids (SCFAs): A Summary Review and Own Experience
Authors: Czarnowski Paweł , Mikula Michał , Ostrowski Jerzy , Żeber-Lubecka Natalia
Published: August 2024

The gut microbiome, crucial to human health, changes with age and disease, and influences metabolic profiles. Gut bacteria produce short-chain fatty acids (SCFAs), essential for maintaining homeostasis and modulating inflammation. Dysbiosis, commonly due to poor diet or lifestyle, disrupts the integrity of the intestinal barrier and may contribute to conditions such as obesity, diabetes, and non-alcoholic fatty liver disease (NAFLD). Analytical methods such as gas chromatography–mass spectrometry (GC/MS) are vital for SCFA analysis, with various preparation and storage techniques improving the accuracy. Advances in these methods have improved the reliability and sensitivity of SCFA quantification, which is crucial for the identification of disease biomarkers. Evidence from GC/MS-based studies has revealed that accurate SCFA quantification requires meticulous sample preparation and handling. The process begins with the extraction of SCFAs from biological samples using methods such as direct solvent extraction or solid-phase microextraction (SPME), both of which require optimization for maximum recovery. Derivatization, which chemically modifies SCFAs to enhance volatility and detectability, is a crucial step, typically involving esterification or silylation. Following this, the cleanup process removes impurities that might interfere with the analysis. Although recent advances in GC/MS technology have significantly improved SCFA-detection sensitivity and specificity, proper sample storage, with acid preservatives and the avoidance of repeated thawing, is essential for maintaining SCFA integrity.
Bone Regeneration Capabilities of Scaffolds Containing Chitosan and Nanometric Hydroxyapatite—Systematic Review Based on In Vivo Examinations
Authors: Piszko Paweł J. , Piszko Aleksandra , Kiryk Sylwia , Kiryk Jan , Horodniczy Tomasz , Struzik Natalia , Wiśniewska Kamila , Matys Jacek , Dobrzyński Maciej
Published: August 2024

In this systematic review, the authors aimed to investigate the state of knowledge on in vivo evaluations of chitosan and nanometric hydroxyapatite (nanohydroxyapatite, nHAp) scaffolds for bone-tissue regeneration. In March 2024, an electronic search was systematically conducted across the PubMed, Cochrane, and Web of Science databases using the keywords (hydroxyapatite) AND (chitosan) AND (scaffold) AND (biomimetic). Methodologically, the systematic review followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) protocol to the letter. Initially, a total of 375 studies were screened, and 164 duplicates were removed. A further 188 articles were excluded because they did not correspond to the predefined topics, and an additional 3 articles were eliminated due to the inability to obtain the full text. The final compilation included 20 studies. All publications indicated a potential beneficial effect of the scaffolds in in vivo bone defect repair. A beneficial effect of hydroxyapatite as a scaffold component was observed in 16 studies, including greater mechanical resistance, cellular differentiation, and enhanced bone damage regeneration. The addition of chitosan and apatite ceramics, which combined the strengths of both materials, had the potential to become a useful bone-tissue engineering material.
Centrifugal Microfluidic Cell Culture Platform for Physiologically Relevant Virus Infection Studies: A Case Study with HSV-1 Infection of Periodontal Cells
Authors: Christfort Juliane Fjelrad , Ortis Morgane , Nguyen Hau Van , Marsault Robert , Doglio Alain
Published: August 2024

Static well plates remain the gold standard to study viral infections in vitro, but they cannot accurately mimic dynamic viral infections as they occur in the human body. Therefore, we established a dynamic cell culture platform, based on centrifugal microfluidics, to study viral infections in perfusion. To do so, we used human primary periodontal dental ligament (PDL) cells and herpes simplex virus-1 (HSV-1) as a case study. By microscopy, we confirmed that the PDL cells efficiently attached and grew in the chip. Successful dynamic viral infection of perfused PDL cells was monitored using fluorescent imaging and RT-qPCR-based experiments. Remarkably, viral infection in flow resulted in a gradient of HSV-1-infected cells gradually decreasing from the cell culture chamber entrance towards its end. The perfusion of acyclovir in the chip prevented HSV-1 spreading, demonstrating the usefulness of such a platform for monitoring the effects of antiviral drugs. In addition, the innate antiviral response of PDL cells, measured by interferon gene expression, increased significantly over time in conventional static conditions compared to the perfusion model. These results provide evidence suggesting that dynamic viral infections differ from conventional static infections, which highlights the need for more physiologically relevant in vitro models to study viral infections.
User Acceptance of Blockchain Technology in Financial Applications: Information Security, Technology Awareness and Privacy Aspects
Authors: Tse Woon Kwan , Dai Xuechen , Lee Yat Ming , Lu Danqi
Published: August 2024

Blockchain technology is now an advanced and innovative database technology and the attributes of blockchains are apparent in a variety of industries, especially in the financial industry. One of the most famous blockchain use cases, cryptocurrencies, has provoked much interest in social network users and customers. According to CoinMarketCap’s information, the global crypto market capitalization has reached around USD 2.37 T and there are around 9975 different cryptocurrencies available in the market. Despite the fact that academia and industry have paid much attention towards the blockchain direction, there is not much research on the factors that influence customer acceptability. This paper studies blockchains from a different angle, probing the factors prompting customers to use financial applications that utilize blockchain technology. We established the model and sorted the individual factors of perceived information security, technology awareness and privacy and found that users’ acceptance is significantly affected by information security and technology awareness, while privacy does not significantly influence users. According to the findings, we provide useful insights for application developers, conclude by presenting the limitations of the research and provide guidelines for future research.
The Role of Interoceptive Sensitivity and Hypnotizability in Motor Imagery
Authors: Malloggi Eleonora , Zelič Žan , Santarcangelo Enrica Laura
Published: August 2024

Motor imagery (MI) requires the mental representation of the body, obtained by integrating exteroceptive and interoceptive information. This study aimed to investigate the role of interoceptive sensitivity (IS) in MI performed through visual and kinesthetic modalities by participants with low (lows, N = 26; SHSS: A, M + SD: 1.00 + 1.52), medium (mediums, N = 11; SHSS: A, 6.00 + 0.77) and high hypnotizability scores (highs, N = 16; SHSS:A, 9.75 + 1.24), as measured by the Stanford Hypnotic Susceptibility Scale: Form A. The three groups displayed different MI abilities and IS levels. The efficacy of MI was measured using the chronometric index and self-reported experience, while IS was measured using the Multidimensional Assessment of Interoceptive Awareness (MAIA) questionnaire. Alpha and beta power spectrum densities (PSDs) were extracted from the EEG signals acquired during baseline, actual movement and visually and kinesthetically imagined movements. The chronometric indices do not reveal significant differences between groups and imagery modalities. The self-report MI efficacy indicates better kinesthetic imagery in highs and mediums than in lows, and no modality difference among lows. The MAIA dimensions sustain the differences in subjective experience and almost all the EEG differences. The latter are slightly different in highs, mediums and lows. This is the first report of the major role played by IS in MI and strongly supports the theory of embodied cognition.
Orchestrating Teacher, Peer, and Self-Feedback to Enhance Learners’ Cognitive, Behavioral, and Emotional Engagement and Public Speaking Competence
Authors: Liu Tingting , Aryadoust Vahid
Published: August 2024

Previous research on providing feedback on public speaking has investigated the effectiveness of feedback sources, namely teacher feedback, peer feedback, and self-feedback, in enhancing public speaking competence, predominantly individually. However, how these sources of feedback can be collectively harnessed to optimize learner engagement and public speaking performance still warrants further investigation. Adopting a pre- and post-test quasi-experimental design, this study randomly assigned four classes to four feedback conditions: Group 1 received teacher feedback, Group 2 self-feedback and teacher feedback, Group 3 peer and teacher feedback, and Group 4 feedback from all three sources. Both student engagement, measured using the Public Speaking Feedback Engagement Scale (PSFES), and their public speaking performance ratings, assessed using the Public Speaking Competency Instrument (PSCI), were validated using Rasch analysis. The inferential statistics revealed that Group 3 showed significant improvements across nearly all three dimensions of engagement, whereas Group 2 experienced significant declines in all dimensions of engagement except behavioral engagement. Group 3 demonstrated significantly greater engagement gain compared to Groups 2 and 4, indicating the synergistic effect of peer and teacher feedback in contrast to the limited impact of self-feedback. Additionally, all groups demonstrated significant improvements except for Group 2, which showed significantly lower improvement compared to Group 4. The following correlation analysis identified a significant correlation between the gain of students’ behavioral engagement and the gain of public speaking performance, whereas such association was absent between cognitive or emotional engagement and public speaking competence. This study suggests that peer feedback should be preceded by group discussion and supplemented with teacher feedback in classes for enhancing the teacher–student dialog, while self-feedback should be conducted after class to improve student engagement and public speaking performance.
An Empirical Study to Understand Symbolic and Sensory Metaphors in Architecture: Case of Kyrenia/Cyprus
Authors: Kayalar Rasiha , Uluğ Erçim
Published: August 2024

This article is a systematic investigation into the symbolic and sensory metaphors in architectural buildings. It presents definition and differentiation of symbolic (stereotype images) and sensory (architectural experience) metaphors. According to the semiotics model of architecture, they are tested empirically and the results are presented in order to understand their influence in architecture. In this regard, this paper designed a research method and adapted a novel semiotic model to investigate the relationship between sensory metaphors (architectural experience) and symbolic metaphors. The cases included six distinctive buildings and 30 subjects. Results demystified that buildings high in connotative qualities do not always connote positive architectural experience. A building with a high number of symbolic metaphors could create a high number of sensory metaphors but these sensory metaphors may not be necessarily positive feelings and experiences.
Understanding Toughening Mechanisms and Damage Behavior in Hybrid-Fiber-Modified Mixtures Using Digital Imaging
Authors: Yang Yaohui , He Yinzhang , Fu Rui , Zhao Xiaokang , Shang Hongfa , Ma Chuanyi
Published: August 2024

Pavement cracking is a primary cause of early damage in asphalt pavements, and fiber-reinforcement technology is an effective method for enhancing the anti-cracking performance of pavement mixtures. However, due to the multi-scale dispersed structure of pavement mixtures, it is challenging to address cracking and damage with a single fiber type or fibers of the same scale. To investigate the toughening mechanisms and damage behavior of hybrid-fiber-modified mixtures, we analyzed the fracture process and damage behavior of these mixtures using a combination of basalt fiber and calcium sulfate whisker hybrid fiber modification, along with semicircular bending tests. Additionally, digital imaging was employed to examine the fracture interface characteristics, revealing the toughening mechanisms at play. The results demonstrated that basalt fibers effectively broaden the toughness range of the modified mixture at the same temperature, reduce mixture stiffness, increase residual load at the same displacement, and improve crack resistance in the mixture matrix. While calcium sulfate whiskers enhanced the peak load of the mixture, their high stiffness modulus was found to be detrimental to the mixture’s crack toughness. The fracture interface analysis indicated that the three-dimensionally distributed fibers form a spatial network within the mixture, restricting the relative movement of cement and aggregate, delaying crack propagation, and significantly improving the overall crack resistance of the mixture.
Risk Analysis in International Construction Projects: A Look at the Prefabricated Wood Construction Sector in the Province of Quebec
Authors: Guimarães Luciana Gondim de A. , Blanchet Pierre , Cimon Yan
Published: August 2024

Construction projects that are completed abroad involve not only the typical risks that are faced at home but also various complex risks that are specific to international transactions. However, little research has been conducted on the risks that exist in prefabricated construction projects, but they need to be discussed. This paper aims to analyze the operational and financial risks associated with the internationalization of small and medium-sized enterprises (SMEs) in the province of Quebec operating in the prefabricated wood construction sector in the American market. Firstly, a literature review was carried out on operational and financial risks in overseas construction projects. This research identified 36 risks, including 21 operational and 15 financial. Next, the risks identified were divided into eight categories: design, standards, coordination, resources, internal to the alliance, partner, customer, and market. Professionals from different types of wood prefabrication companies were then asked to identify the probability of occurrence and magnitude of the impact of each identified risk. This information was used to calculate the criticality of each risk using Monte Carlo simulation to generate scenarios for use as a decision-making tool in risk assessment. The results show that highly critical operational risks are concentrated in the operational risk categories of coordination and resources. It should be noted that the most critical risk is that of ineffective communication and coordination, which is linked to project governance. On the other hand, financial risks with high criticality are spread across the four financial risk categories. A comparison of the criticality of the operational and financial risks identified revealed that the financial risks were the most critical.
Real-Life Management of FLT3-Mutated AML: Single-Centre Experience over 24 Years
Authors: Capria Saveria , Trisolini Silvia Maria , Torrieri Lorenzo , Amabile Elena , Marsili Giovanni , Piciocchi Alfonso , Barberi Walter , Iori Anna Paola , Diverio Daniela , Carmini Daniela , Breccia Massimo , Martelli Maurizio , Minotti Clara
Published: August 2024

We analyzed 140 patients with a median age of 51 years; 21% had WBC ≥ 100 × 109/L, and 52% had an NPM1 co-mutation. Until 2018, 101 patients received chemotherapy; thereafter, 39 received 3+7+midostaurin. The overall CR rate was 64%, higher in NPM1 mutant patients (73%). Univariate analysis showed that NPM1 mutation (p = 0.032) and WBC < 100 × 109/L (p = 0.013) positively influenced the response, with a trend for FLT3i administration (p = 0.052). Multivariate analysis confirmed WBC count as an independent prognostic factor (p = 0.017). In CR1, 41/90 patients underwent allogeneic and 18 autologous transplantation. The median EFS was 1.1 vs. 1.6 years in autografted and allografted patients, respectively (p = 0.9). The one-year non-relapse mortality was 0.00% for autologous and 28% for allogeneic transplants (p = 0.007); CIR at 1 and 3 years was higher in autologous transplants (39% vs. 15% and 57% vs. 21%, p = 0.004). The median survival was not reached in the FLT3i group. Overall, 69 patients received stem cell transplantation (18 autologous, 51 allogeneic). Post-transplant FLT3i was resumed in eight patients, all alive after a median of 65 months. Allogeneic transplantation is crucial in FLT3-mutated AML, but the next challenge will be to identify which patients can benefit from transplants in CR1 and in which to intensify post-transplant therapy.
Cutaneous Squamous Cell Carcinoma of the Head and Neck: Pathological Features and What They Mean for Prognosis and Treatment
Authors: Ramesh Uma , Chiang Elizabeth , Stafford Haleigh , Buell Jane , Materia Frank , Amit Moran , Yaniv Dan
Published: August 2024

Cutaneous squamous cell carcinoma (cSCC) is one of the most common cancers worldwide, with an incidence that has increased over the past 30 years. Although usually curable with excision, cSCC can become widely metastatic and aggressive with poor outcomes. Whereas the clinical and radiographic extent of any cancer will always guide selection of treatment modality, pathological features of cSCC also play an important role in determining prognosis and, subsequently, the need for further therapy. Therefore, reviewing and summarizing the current literature regarding pathological prognostic indicators of cSCC is essential to improving clinical outcomes. The present literature review yielded depth of invasion, surgical margins, perineural invasion, extranodal extension, lymphovascular invasion, tumor grade, tumor subtype, premalignant lesions, and molecular markers as key prognostic indicators, all with varying recommendations for adjuvant therapy. Notably, some of these factors have not been incorporated into either the American Joint Committee on Cancer staging system (8th edition) or National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology for cSCC. This review highlights a need for further research into these prognostic indicators and their role in determining the need for adjuvant treatment in head and neck cSCC.
Risk and Protective Factors of Postoperative and Persistent Hypoparathyroidism after Total Thyroidectomy in a Series of 1965 Patients
Authors: Dughiero Silvia , Torresan Francesca , Censi Simona , Mian Caterina , Carrillo Lizarazo José Luis , Iacobone Maurizio
Published: August 2024

Background: Postoperative hypoparathyroidism (HypoPTH) is the most common complication following total thyroidectomy. Several risk factors have been identified, but data on postoperative follow-up are scarce. Methods: The study focused on 1965 patients undergoing surgery for benign and malignant thyroid diseases at a tertiary-level academic center. Anamnestic, biochemical, surgical, pathological, and follow-up data were evaluated. HypoPTH was defined by a serum concentration of PTH < 10 pg/mL on the first or the second post-operative day. Persistent HypoPTH was defined by the need for calcium/active vitamin D treatment > 12 months after surgery. Results: Postoperative HypoPTH occurred in 542 patients. Multivariate analysis identified the association of central lymph-nodal dissection, reduced preoperative PTH levels, a lower rate of parathyroid glands preserved in situ, and longer duration of surgery as independent risk factors. At a median follow-up of 47 months, HypoPTH regressed in 443 patients (more than 6 months after surgery in 7%) and persisted in 53 patients. Patients receiving a lower dose of calcium/active vitamin D treatment at discharge (HR 0.559; p < 0.001) or undergoing prolonged, tailored, and direct follow-up by the operating endocrine surgeon team had a significantly lower risk of persistent HypoPTH (2.4% compared to 32.8% for other specialists) (HR 2.563; p < 0.001). Conclusions: Various patient, disease, and surgeon-related risk factors may predict postoperative HypoPTH. Lower postoperative calcium/active vitamin D treatment and prolonged, tailored follow-up directly performed by operating endocrine surgeons may significantly reduce the rate of persistent HypoPTH.
Molecular Analysis of Salivary and Lacrimal Adenoid Cystic Carcinoma
Authors: Powell Sarah , Kulakova Karina , Hanratty Katie , Khan Rizwana , Casserly Paula , Crown John , Walsh Naomi , Kennedy Susan
Published: August 2024

Adenoid cystic carcinoma (ACC) of head and neck origin is associated with slow but relentless progression and systemic metastasis, resulting in poor long-term survival rates. ACC does not respond to conventional chemotherapy. Determination of molecular drivers may provide a rational basis for personalized therapy. Herein, we investigate the clinical and detailed molecular genomic features of a cohort of patients treated in Ireland and correlate the site of origin, molecular features, and outcomes. Clinical and genomic landscapes of all patients diagnosed with ACC over a twenty-year period (2002–2022) in a single unit in Ireland were examined and analyzed using fluorescence in situ hybridization, DNA sequencing, and bioinformatic analysis. Fourteen patients were included for analysis. Eleven patients had primary salivary gland ACC and three primary lacrimal gland ACC; 76.9% of the analyzed tumors displayed evidence of NFIB-MYB rearrangement at the 6q23.3 locus; 35% had mutations in NOTCH pathway genes; 7% of patients had a NOTCH1 mutation, 14.3% NOTCH2 mutation, and 14.3% NOTCH3 mutation. The presence of epigenetic modifications in ACC patients significantly correlated with worse overall survival. Our study identifies genetic mutations and signaling pathways that drive ACC pathogenesis, representing potential molecular and therapeutic targets.
Profiling the Cardiovascular Toxicities of CDK4/6 Inhibitors: A Real-World Pharmacovigilance Study
Authors: Kim Jae Hyun
Published: August 2024

Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are approved for the treatment of human epidermal growth factor receptor 2 (HER-2)-negative, hormone receptor-positive breast cancer. The cardiovascular toxicity of CDK4/6 inhibitors is not well understood. This study aims to profile the cardiac events associated with CDK4/6 inhibitors. Reports from 2015Q1 to 2024Q1 were obtained from the FDA Adverse Event Reporting System (FAERS). Reports identifying palbociclib, ribociclib, and abemaciclib as the primary suspect were examined for cardiovascular toxicity, including hypertension, cardiac failure, cardiomyopathy, arrhythmia, myocardial infarction, and myocarditis. Signal detection was performed using the proportional reporting ratio (PRR), reporting odds ratio (ROR), and information component (IC). A total of 69,139 reports were analyzed. The median time to adverse events was 69 days (interquartile range [IQR], 18–260 days). Of these, 2065 reports documented cardiac adverse events. Ribociclib and QT prolongation were re-confirmed as a signal (PRR 8.43, ROR 8.65, IC025 2.86). Hypertension and cardiac failure were the most frequently reported cardiovascular toxicities. This study demonstrates that the use of CDK4/6 inhibitors is associated with cardiovascular adverse events, such as heart failure and hypertension. Further research is needed to understand the mechanisms and risk factors contributing to the cardiovascular toxicity of CDK4/6 inhibitors.
Comparative Analysis of Repeatability in CT Radiomics and Dosiomics Features under Image Perturbation: A Study in Cervical Cancer Patients
Authors: Ma Zongrui , Zhang Jiang , Liu Xi , Teng Xinzhi , Huang Yu-Hua , Zhang Xile , Li Jun , Pan Yuxi , Sun Jiachen , Dong Yanjing , Li Tian , Chan Lawrence Wing Chi , Chang Amy Tien Yee , Siu Steven Wai Kwan , Cheung Andy Lai-Yin , Yang Ruijie , Cai Jing
Published: August 2024

This study aims to evaluate the repeatability of radiomics and dosiomics features via image perturbation of patients with cervical cancer. A total of 304 cervical cancer patients with planning CT images and dose maps were retrospectively included. Random translation, rotation, and contour randomization were applied to CT images and dose maps before radiomics feature extraction. The repeatability of radiomics and dosiomics features was assessed using intra-class correlation of coefficient (ICC). Pearson correlation coefficient (r) was adopted to quantify the correlation between the image characteristics and feature repeatability. In general, the repeatability of dosiomics features was lower compared with CT radiomics features, especially after small-sigma Laplacian-of-Gaussian (LoG) and wavelet filtering. More repeatable features (ICC > 0.9) were observed when extracted from the original, Large-sigma LoG filtered, and LLL-/LLH-wavelet filtered images. Positive correlations were found between image entropy and high-repeatable feature number in both CT and dose (r = 0.56, 0.68). Radiomics features showed higher repeatability compared to dosiomics features. These findings highlight the potential of radiomics features for robust quantitative imaging analysis in cervical cancer patients, while suggesting the need for further refinement of dosiomics approaches to enhance their repeatability.
Risk Factors of Distant Recurrence and Dissemination of IDH Wild-Type Glioblastoma: A Single-Center Study and Meta-Analysis
Authors: Tsuchiya Takahiro , Kawauchi Daisuke , Ohno Makoto , Miyakita Yasuji , Takahashi Masamichi , Yanagisawa Shunsuke , Osawa Sho , Fujita Shohei , Omura Takaki , Narita Yoshitaka
Published: August 2024

Isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM) is a highly aggressive brain tumor with a high recurrence rate despite adjuvant treatment. This study aimed to evaluate the risk factors for non-local recurrence of GBM. In the present study, we analyzed 104 GBMs with a single lesion (non-multifocal or multicentric). Univariate analysis revealed that subventricular zone (SVZ) involvement was significantly associated with non-local recurrence (hazard ratio [HR]: 2.09 [1.08–4.05]). Tumors in contact with the trigone of the lateral ventricle tended to develop subependymal dissemination (p = 0.008). Ventricular opening via surgery did not increase the risk of non-local recurrence in patients with SVZ involvement (p = 0.190). A systematic review was performed to investigate the risk of non-local recurrence, and 21 studies were identified. A meta-analysis of previous studies confirmed SVZ involvement (odds ratio [OR]: 1.30 [1.01–1.67]) and O-6-methylguanine DNA methyltransferase promoter methylation (OR: 1.55 [1.09–2.20]) as significant risk factors for local recurrence. A time-dependent meta-analysis revealed a significant association between SVZ involvement and dissemination (HR: 1.69 [1.09–2.63]), while no significant association was found for distant recurrence (HR: 1.29 [0.74–2.27]). Understanding SVZ involvement and specific tumor locations associated with non-local recurrence provides critical insights for the management of GBM.
Advances in Soft Tissue and Bone Sarcoma
Authors: Rutland Catrin S.
Published: August 2024

This Cancers Special Issue on bone and soft tissue sarcomas highlights the latest discoveries in soft tissue and bone cancers from the laboratory through to the clinics, from bench to bedside, and beyond [...]
Non-Small-Cell Lung Cancers (NSCLCs) Harboring RET Gene Fusion, from Their Discovery to the Advent of New Selective Potent RET Inhibitors: “Shadows and Fogs”
Authors: Spitaleri Gianluca , Trillo Aliaga Pamela , Attili Ilaria , Del Signore Ester , Corvaja Carla , Pellizzari Gloria , Katrini Jalissa , Passaro Antonio , de Marinis Filippo
Published: August 2024

RET fusions are relatively rare in Non-Small-Cell Lung Cancers (NSCLCs), being around 1–2% of all NSCLCs. They share the same clinical features as the other fusion-driven NSCLC patients, as follows: younger age, adenocarcinoma histology, low exposure to tobacco, and high risk of spreading to the brain. Chemotherapy and immunotherapy have a low impact on the prognosis of these patients. Multitargeted RET inhibitors have shown modest activity jeopardized by high toxicity. New potent and selective RET inhibitors (RET-Is) (pralsetinib and selpercatinib) have achieved a higher efficacy minimizing the known toxicities of the multitargeted agents. This review will describe the sensitivity of immune-checkpoint inhibitors (ICIs) in RET fusion + NSCLC patients, as well their experiences with the ‘old’ multi-targeted RET inhibitors. This review will focus on the advent of new potent and selective RET-Is. We will describe their efficacy as well as the main mechanisms of resistance to them. We will further proceed to deal with the new drugs and strategies proposed to overcome the resistance to RET-Is. In the last section, we will also focus on the safety profile of RET-Is, dealing with the main toxicities as well as the rare but severe adverse events.
The Genetic Analysis and Clinical Therapy in Lung Cancer: Current Advances and Future Directions
Authors: Rina Angela , Maffeo Debora , Minnai Francesca , Esposito Martina , Palmieri Maria , Serio Viola Bianca , Rosati Diletta , Mari Francesca , Frullanti Elisa , Colombo Francesca
Published: August 2024

Lung cancer, including both non-small cell lung cancer and small cell lung cancer, remains the leading cause of cancer-related mortality worldwide, representing 18% of the total cancer deaths in 2020. Many patients are identified already at an advanced stage with metastatic disease and have a worsening prognosis. Recent advances in the genetic understanding of lung cancer have opened new avenues for personalized treatments and targeted therapies. This review examines the latest discoveries in the genetics of lung cancer, discusses key biomarkers, and analyzes current clinical therapies based on this genetic information. It will conclude with a discussion of future prospects and potential research directions.