bluuebunny/crossref_metadata_2025 huggingface dataset:
Decomposition of Estuarine Circulation and Residual Stratification under Landfast Sea Ice
Authors: Burchard Hans , Bolding Karsten , Lange Xaver , Osadchiev Alexander
Published: November 2022

For Arctic estuaries that are characterized by landfast sea ice cover during the winter season, processes generating estuarine circulation and residual stratification have not yet been investigated, although some of the largest estuaries in the world belong to this class. Landfast sea ice provides a no-slip surface boundary condition in addition to the bottom boundary, such that frictional effects are expected to be increased. For this study of estuarine circulation and residual stratification under landfast sea ice, first, a simple linear analytical model is used. To include tidally varying scenarios, a water-column model is applied with a second-moment turbulence closure to juxtapose free-surface and ice-covered estuaries. Well-mixed and strongly stratified tidally periodic scenarios are analyzed by means of a decomposition of estuarine circulation into contributions from gravitational circulation, eddy viscosity–shear covariance (ESCO), surface stress, and river runoff. A new method is developed to also decompose tidal residual salinity anomaly profiles. Estuarine circulation intensity and tidally residual potential energy anomaly are studied for a parameter space spanned by the Simpson number and the unsteadiness number. These are the major results of this study that will support future scenario studies in Arctic estuaries under conditions of accelerated warming: (i) residual surface drag under ice opposes estuarine circulation; (ii) residual differential advection under ice destabilizes the near-surface flow; (iii) reversal of ESCO during strong stratification does not occur under landfast sea ice; (iv) tidal pumping (s-ESCO) contributes dominantly to residual stratification also with sea ice cover.

Significance Statement

Our work gives a first qualitative and quantitative understanding of how landfast sea ice cover on tidal estuaries impacts on the generation of estuarine circulation and residual stratification. Along the Arctic coasts, where some of the world’s largest estuaries are located, these processes play a significant role for the economy and ecology by means of transports of sediments, nutrients and pollutants. Due to Arctic amplification, the conditions for ice-covered estuaries are strongly changing in a way that the ice-covered periods may be shorter in the future. Our results intend to motivate field observations and realistic model studies to allow for better predicting the consequences of these changes.
Tidally Forced Turbulent Dissipation on a Three-Dimensional Fan in Luzon Strait
Authors: Alford Matthew H. , Nash Jonathan D. , Buijsman Maarten
Published: November 2022

Moored observations and a realistic, tidally forced 3D model are presented of flow and internal-tide-driven turbulence over a supercritical 3D fan in southeastern Luzon Strait. Two stacked moored profilers, an acoustic Doppler current profiler, and a thermistor string measured horizontal velocity, density, and salinity over nearly the entire water column every 1.5 h for 50 days. Observed dissipation rate computed from Thorpe scales decays away from the bottom and shows a strong spring–neap cycle; observed depth-integrated dissipation rate scales as where UBT is the barotropic velocity. Vertical velocities are strong enough to be comparable at times to the vertical profiling speed of the moored profilers, requiring careful treatment to quantify bias in dissipation rate estimates. Observations and the model are in reasonable agreement for velocity, internal wave displacement and depth-integrated dissipation rate, allowing the model to be used to understand the 3D flow. Turbulence is maximum following the transition from up-fan to down-fan flow, consistent with breaking lee waves advected past the mooring as seen previously at the Hawaiian Ridge, but asymmetric flow arises because of the 3D topography. Observed turbulence varies by a factor of 2 over the four observed spring tides as low-frequency near-bottom flow changes, but the exact means for inclusion of such low-frequency effects is not clear. Our results suggest that for the extremely energetic turbulence associated with breaking lee waves, dissipation rates may be quantitatively predicted to within a factor of 2 or so using numerical models and simple scalings.

Significance Statement

This paper describes deep ocean turbulence caused by strong tidal and low-frequency meandering flows over and around a three-dimensional bump, using moored observations and a computer simulation. Such information is important for accurately including these effects in climate simulations. The observations and model agree well enough to be able to use both to synthesize a coherent picture. The observed and modeled turbulence scale as the cube of the tidal speed as expected from theory, but low-frequency flows complicate the picture. We also demonstrate the underestimation of the turbulence that can result when vertical profiling rates are comparable to the internal wave velocities.
Impact of Data Resolution on Tracking Southern Ocean Cyclones
Authors: Zhong Rui , Yang Qinghua , Hodges Kevin , Wu Renhao , Chen Dake
Published: November 2022

The ERA5 new generation of high-resolution reanalysis provides a possibility to obtain more accurate cyclone tracks in the Southern Ocean. With a commonly used cyclone tracking algorithm, this study evaluates the impact of data resolution on Southern Ocean cyclone tracks for the period from 1980 to 2020 by preprocessing the ERA5 dataset at different spatial and temporal resolutions. A new track-matching method is proposed to assure an accurate comparison of different track datasets, considering the multiple match pairs and best match pair for each track. It is found that the number, distribution, and characteristics of cyclones are considerably different for various resolution scenarios. The higher spatial resolution captures more tracks, while the increased temporal resolution decreases the number, as well as the lifetime and the moving distance of tracks. The shared cyclones of different track datasets show different characteristics, influenced by both spatial and temporal resolutions. Higher spatial resolution schemes tend to identify more additional track points after the overlapping time of shared tracks rather than before. The spatial distribution pattern of additional track points is consistent when increasing temporal or spatial resolution separately. These results are a reference for the application of objective tracking algorithms in the Southern Ocean using input data with higher resolution.

Significance Statement

Automatic tracking algorithms are important tools for the research of cyclones and their associated weather phenomena. High-resolution input data are available now for cyclone tracking but it also brings more noise that may affect the results. The problem can be solved by a preprocess (smoothing) process using suitable spatial and temporal resolutions. This study compared the features of Southern Ocean cyclones obtained by different spatial and temporal resolution schemes. We further study the shared cyclones in different track datasets with a new track-matching method and discuss the different impacts of spatial and temporal resolution, as well as provide a reference for the application and improvement of cyclone tracking in the future.
Understanding Pediatric Mental Health in Primary Care: Needs in a Rural State
Authors: Harris Kari , Aguila Gonzalez Amanda , Vuong Ngoc , Brown Rachel , Ciccolari Micaldi Susanna
Published: November 2022

The need for mental health care for pediatric patients outstrips the supply, especially in states, like Kansas, that experience shortages of mental health professionals. Pediatric mental health care access programs, like KSKidsMAP (Kansas Kids Mental health Access Program), increase access to care by building competence and confidence in primary care physicians and clinicians (PCPs) through a statewide integrated system that includes a consultation line. This study is a secondary analysis of KSKidsMAP consultation Line inquiries regarding patients aged 0 to 21 years with mental and behavioral health concerns. The study employs a mixed-method approach with descriptive statistics and thematic analysis of inquiries. Five themes were identified: (1) pharmacotherapy, (2) diagnostic evaluation, (3) community resources, (4) psychotherapy, and (5) other. This study sheds light on PCPs needs and illustrates the importance of Pediatric Mental Health Care Access programs offering interprofessional expertise to consulting PCPs, allowing for expansion of pediatric mental illness care into the primary care setting.
Victimization of the Dead: Exploring Burglars Use of Publicly Available Obituary Information to Perpetrate Their Crimes
Authors: Beard Virginia R. , Burger William C.
Published: November 2022

The present study uses primary data collected by the researchers on residential burglaries committed in the time-period of 1991–2021 to analyze the individual year frequency of obituary burglaries and patterns across time in relation to obituary burglaries. The goal is to assess the frequency of this form of burglary and the potential impact of increased web based publishing of obituaries on incidents of residential burglaries during funerary rites. Findings indicate that while this form of burglary is rare, it is a niche form of residential burglary committed by specialized burglars who utilize information available about funerals to specifically target the family of the deceased’s home or the vacant home of the deceased. Recommendations for protecting against this form of victimization are provided.
Impact of the COVID-19 Pandemic on National Institutes of Health–Funded Researchers and Their Projects: The Role of Age, Sex, Experience, and Team Size
Authors: Burnett Wendy J. , Agbali Raphael , Silva Jeane , De Leo Gianluca
Published: November 2022

Objectives:

The COVID-19 pandemic has disrupted the social life, work environment, and well-being of millions of people. We examined COVID-19’s impact on National Institutes of Health (NIH)–funded extramural principal investigators (PIs) affiliated with public health and preventive medicine departments across the country and their projects; assessed PIs’ confidence in achieving project goals; and investigated the role of age, sex, experience, and team size on PIs’ confidence in achieving project goals during the pandemic.

Methods:

We sent an anonymous online survey in January 2021 to 1076 extramural PIs affiliated with public health and preventive medicine departments at US institutions; 133 (12.4%) responded. We examined the impact of COVID-19 on the PIs, their project team operations, and their confidence that project objectives would be met, using Likert scales based on age, sex, team size, and PI experience.

Results:

Of 126 PIs, 94 (74.6%) felt that their day-to-day professional life was impacted a lot or a great deal by COVID-19. More female PIs than male PIs reported that their level of stress changed because of the COVID-19 pandemic. Of 125 PIs, 67 (53.6%) made major adjustments to research operations, 46 (36.8%) made minor adjustments, 5 (4.0%) halted research, and 7 (5.6%) reported not being affected. Of 123 PIs, 89 (72.4%) reported not using NIH COVID-19 accommodations. PIs who led projects 4 or 5 times felt more confident about meeting their research objectives than PIs who led projects 2 or 3 times.

Conclusions:

Future studies should investigate how to develop more engaging support and communication strategies to assist NIH researchers in mitigating the effects of pandemics or large-scale emergencies.
Results of a collaborative professional development for school staff working with students with visual impairments and challenging behavior
Authors: Robertson Rachel E , Buonomo Kristen , McCarthy Tessa
Published: November 2022

Students with visual impairments (VI) and multiple disabilities (MD) often exhibit challenging behavior, yet school staff’s use of evidence-based practices in behavior management is reportedly low. In this article, we share the results of a collaborative professional development (PD) aimed at increasing school staff buy-in and use of individualized positive behavior interventions and supports (I-PBIS) with students with VI and MD. Ten staff, including teachers, paraeducators, and related services, working in a self-contained school for students with VI participated in four weekly, collaborative small group modules on research-based I-PBIS strategies. The Covid-19 pandemic occurred mid-study, which affected implementation of the program and collection of outcome data; however, pre- to post-PD participants’ supportive beliefs regarding I-PBIS increased significantly. Participant-reported knowledge and use of I-PBIS also increased but did not reach significance. In addition, participants found the PD highly acceptable and useful in their work with students with VI and MD who engage in challenging behavior. Implications for increasing school staff support for and use of I-PBIS with students with VI and MD are discussed.
Mechanical and thermo-mechanical properties of glass fiber reinforced epoxy composites with boron carbide nanofiller
Authors: Srinivasan Raju , Kamaraj Muthusamy
Published: November 2022

This research aims to analyze the influence of boron carbide particles (B4C) on the mechanical and thermo-mechanical characteristics of glass fabric reinforced epoxy to identify the suitability of fabricated composites in an automotive application. The influence of B4C up to 0.4 wt% is analyzed by mixing with epoxy resin using a magnetic stirring approach, followed by compression molding with the glass fiber reinforcement. The results revealed that the hardness of glass strengthened epoxy was increased by 38%, and the other mechanical characteristics such as tensile and flexural strength were raised by 25% and 19%, respectively, when the weight fractions of B4C were raised to 0.3 wt%. From the fractography, it was observed that the fiber pull-out and fiber fracture were the dominant failure mechanisms in the developed composites during the application. The findings of the dynamic mechanical analysis revealed that the storage and loss modulus of the composites was increased by 50% and 43%, respectively, with the 0.3 wt% of B4C showing the increase in the dynamic ability of materials even at elevated temperatures.
Criminalizing Muslim agency in Europe: The case of ‘political Islam’ in Austria, Germany, and France
Authors: Hafez Farid
Published: November 2022

This article discusses the emergence of a discourse on ‘political Islam’ in the policy circles of European elites. It interprets this discourse on one hand as a manifestation of the further criminalization of Muslimness emanating from programs of countering ‘extremism’ and deradicalizing Muslim youth in the wake of the global war on terror. More specifically, the discourse on ‘political Islam’ is seen as an extension of countering violent extremism projects to counter an alleged non-violent ‘extremism.’ The article discusses three cases: Austria, Germany, and France to analyze what the fight against ‘political Islam’ (in Austria), ‘legalistic Islamism’ (in Germany), and ‘Islamist separatism’ (in France) respectively mean. These terminologies are analyzed as ‘empty signifiers’ and (Foucauldian) dispositifs that are used deliberately to legitimize state interventions to shape their respective societies. It is argued that the main shared idea is not that Muslims break the law or commit violence. Rather, the argument is that Muslims use the law to subvert their European nation-states. This aims at excluding Muslims from political life and not allowing them to shape the future of these countries. A simultaneous effort is the nurturing of an unpolitical, submissive Muslim that does not question hegemonial power structures, a project which is pursued by creating a domesticated or ‘national Islam.’ The article discusses these three terminologies' similarities and differences in the respective countries. In sum, the apparatus of ‘political Islam’ is interpreted as a means to 1) push back or exclude Muslims from the public sphere; 2) crackdown on organized Muslims; and 3) silence critical voices to these policies.
Psychological and quality of life effects of vaccination against COVID-19 in patients with systemic autoimmune diseases
Authors: Montero-López Eva , Peralta-Ramírez María Isabel , Ortego-Centeno Norberto , Callejas-Rubio José Luis , Ríos-Fernández Raquel , Santos-Ruiz Ana
Published: November 2022

To verify the psychological and quality of life benefits of vaccination against COVID-19 in patients with systemic autoimmune diseases. In this study, levels of psychological stress, psychopathological symptoms, quality of life, and satisfaction with life were compared in patients with systemic autoimmune diseases vaccinated against COVID-19 ( n = 132) versus unvaccinated patients ( n = 254). To this end, we used the Perceived Stress Scale (PSS), Symptom Checklist-90-Revised (SCL-90-R), EUROQoL-5Q health questionnaire, and Satisfaction with Life Scale (SWLS), respectively. Statistically significant differences were found with better scores in the vaccinated group in the following quality of life dimensions: mobility ( p ≤ 0.010), domestic activities ( p ≤ 0.004), pain/discomfort ( p ≤ 0.001), and anxiety/depression ( p≤ 0.005). The scores were also significantly higher in the vaccinated group for the total values of quality of life ( p ≤ 0.001), health status self-assessment on the EUROQoL-5Q ( p ≤ 0.043), and satisfaction with life ( p ≤ 0.015). In addition, the unvaccinated group presented higher scores with clinically pathological levels in depression and psychoticism for somatizations ( p ≤ 0.006), depression ( p ≤ 0.015), anxiety ( p ≤ 0.003), and phobic anxiety ( p ≤ 0.001). Finally, participants vaccinated with the complete regimen showed better levels of psychological well-being than those who were not vaccinated or those that had not completed the vaccination regimen. Our results reflect and confirm the positive effects reported elsewhere of the COVID-19 vaccine in autoimmune patients with systemic diseases, both in terms of quality and satisfaction with life as well as psychopathological symptoms and perceived stress. These benefits increased as the patients completed their vaccination schedule.
Long-Term Clinical Efficacy of Human Umbilical Cord Blood Mononuclear Cell Transplantation by Lateral Atlanto-Occipital Space Puncture (Gong’s Puncture) for the Treatment of Multiple System Atrophy
Authors: Gong Dianrong , Wang Weifei , Yuan Xiaoling , Yu Haiyan , Zhao Min
Published: November 2022

Multiple system atrophy (MSA) is a sporadic, progressive neurodegenerative disease characterized by autonomic nervous dysfunction with parkinsonism or cerebellar ataxia. Mesenchymal stem cell therapy or transplantation of human umbilical cord blood mononuclear cells (hUCB-MCs) may inhibit progression in MSA, but long-term studies are lacking. In addition, injection of stem cells via lateral atlanto-occipital space puncture (LASP, or Gong’s puncture) may efficiently target areas of brain injury and avoid the disadvantages of other methods. This prospective study investigated the long-term clinical efficacy of transplantation of hUCB-MCs via LASP for the treatment of MSA. Seven patients with MSA who received hUCB-MC transplantation via LASP were followed for 3 to 5 years. Neurological function was evaluated before (baseline), at 3, 6, and 12 months, and annually after the first transplantation using the Unified MSA Rating Scale (UMSARS); a lower score indicated improvement. Adverse events were recorded. The best therapeutic effect was observed 3 to 6 months after the first hUCB-MC transplantation. The total UMSARS score at the timepoint of best effect (25.71 ± 11.87) was significantly lower than the score before treatment (42.57 ± 7.96; P = 0.001), but also significantly lower than at the end of follow-up (35.14 ± 18.21; P = 0.038). The UMSARS II score (findings on neurological examination) at the timepoint of best effect was significantly lower than before treatment ( P = 0.001). There were no serious adverse events. In conclusion, transplantation of hUCB-MCs via LASP is a safe and effective treatment for MSA.
Global Value Chain Linkages and Employment: Empirical Assessment for India’s Manufacturing Sector
Authors: Bhayana Sakshi , Nag Biswajit
Published: November 2022

We explore the connection between global value chain linkages and employment outcomes for 17 manufacturing sectors in India utilizing panel long run estimator and short run dynamics for the period 1995–2017. We model this relationship within the production function framework and disentangle two significant outcomes. In the first place, we find that in four varieties of the advancement model, employment and value chain linkages exhibit a long run relationship; that is, they are cointegrated. Second, we find that over the long haul, while forward linkages (DVX), compensation to labourers and industrial economic growth have contributed decidedly to employment in manufacturing sector, while the backward linkages (FVA) have had an unimportant impact. Another striking result in the short run shows that in an emerging economy like India, a rise in forward value chain linkage is directly associated with an increase in relative employment of skilled labour force. We draw significant arrangement suggestions from these findings.
Cognitive Performance and Psychiatric Self-Reports Across Adult Cognitive Disengagement Syndrome and ADHD Diagnostic Groups
Authors: Cerny Brian M. , Reynolds Tristan P. , Chang Fini , Scimeca Lauren M. , Phillips Matthew S. , Ogram Buckley Caitlin M. , Leib Sophie I. , Resch Zachary J. , Pliskin Neil H. , Soble Jason R.
Published: November 2022

Objective:

Cognitive disengagement syndrome (CDS) is characterized by inattention, under-arousal, and fatigue and frequently co-occurs with attention-deficit/hyperactivity disorder (ADHD). Although CDS is associated with cognitive complaints, its association with objective cognitive performance is less well understood.

Method:

This study investigated neuropsychological correlates of CDS symptoms among 169 adults ( Mage = 29.4) referred for outpatient neuropsychological evaluation following inattention complaints. We evaluated cognitive and self-report differences across four high/low CDS and positive/negative ADHD groups, and cognitive and self-report correlates of CDS symptomology.

Results:

There were no differences in cognitive performance, significant differences in self-reported psychiatric symptoms (greater CDS symptomatology, impulsivity among the high CDS groups; greater inattention among the positive ADHD/high CDS groups; greater hyperactivity among the positive ADHD groups), significant intercorrelations within cognitive and self-report measures, nonsignificant correlations between cognitive measures and self-report measures.

Conclusion:

Findings support prior work demonstrating weak to null associations between ADHD and CDS symptoms and cognitive performance among adults.
Innovative Approach for a Typology of Treatment Sequences in Early Stage HER2 Positive Breast Cancer Patients Treated With Trastuzumab in the French National Hospital Database
Authors: Tredan Olivier , Laurent Marie , Gilberg Melina , Ghorbal Rim , Vainchtock Alexandre , Lortet-Tieulent Joannie , Prodel Martin , Dupin Julien
Published: November 2022

Background:

Our objective was to describe the hospital-based systemic treatment sequences in early stage HER2+ breast cancer patients treated with trastuzumab in France in 2016.

Methods:

This retrospective observational study was based on the national hospital discharge database (PMSI). Patients hospitalized for breast cancer in 2016 and administration of trastuzumab between 6 months prior and 1 year after surgery were included. The following treatments were identified: (1) trastuzumab ± chemotherapy; (2) chemotherapy alone; (3) q3w trastuzumab weekly chemotherapy. Hospital admissions for cardiac events before and after the surgery were investigated. An unsupervised machine learning technic called TAK (Time-sequence Analysis through K-clustering) was used to identify and visualize typical systemic treatment sequences.

Results:

Overall, 3531 patients were included: 2619 adjuvant cohort patients (74.2%) and 912 neoadjuvant cohort patients (25.8%). The mean age was 56.4 years (±12.3), 99.7% patients were female. Treatment initiation occurred within 6 weeks of the surgery in 58% and 92% of patients, and trastuzumab treatment lasted 12 months (±1 month) in 75% and 66% of patients in the adjuvant and neoadjuvant cohorts, respectively. Nevertheless, 12% and 22% of patients were treated with trastuzumab for <11 months in the adjuvant and neoadjuvant cohorts, respectively. There was not one standard sequence of treatments per cohort, but 4 and 3 typical treatment sequences in the adjuvant and the neoadjuvant cohorts, respectively, plus 2 treatment sequences with an early treatment withdrawal. The frequency of patients with ⩾1 hospital stay with a cardiac event was higher among patients with an early treatment withdrawal.

Conclusions:

The treatment sequences of most patients were in line with the recommendations in force. The machine learning approach provided a telling visual display of the results, thereby allowing healthcare professionals, health authorities, patients, and care givers to see the whole picture of the hospital-administered drug strategies.
Two Fire Temples and a Metro: Contesting Infrastructures in Mumbai
Authors: Vevaina Leilah
Published: November 2022

Mumbai is one of the world’s megacities often depicted through its intensely crowded suburban trains and hours-long traffic jams. The city is now in the midst of a huge transport infrastructural scheme to build a north-south underground metro seen as vital to relieve the congestion of the colonial-era commuter train, which carries seven million passengers every day. Yet, the backlash against the construction has been virulent, from environmental groups and particularly from one micro community, the Parsis (Indian Zoroastrians), who learnt that the Metro line was planned to run beneath two of their oldest and most sacred temples. This article will explore the claims, legitimating narratives, and legal authority of these competing civic and sacred urban infrastructures.
Applying health design thinking to uncover actors in the sustenance of health and wellbeing during hotel quarantine in kuwait
Authors: Selamet Juhri
Published: November 2022

This visual essay centers on the author’s hotel quarantine experience in Kuwait. While many quarantine stories have been recorded, personal stories involving the relationship between human and non-human actors within a quarantined space are still overlooked. By focusing on the maintenance of health and wellness during quarantine, this essay visually communicates the hotel quarantine experience by using a health design thinking approach. By presenting a series of photographs, actors’ interactions, and journey maps, the author attempts to convey a connection between human and non-human actors during quarantine, and prompts a discussion on what can be done to improve hotel quarantine systems in the future.
How Anti-Social Personality Traits and Anti-Establishment Views Promote Beliefs in Election Fraud, QAnon, and COVID-19 Conspiracy Theories and Misinformation
Authors: Enders Adam , Klofstad Casey , Stoler Justin , Uscinski Joseph E.
Published: November 2022

Conspiracy theories and misinformation (CTM) became a salient feature of the Trump era. However, traditional explanations of political attitudes and behaviors inadequately account for beliefs in CTM or the deleterious behaviors they are associated with. Here, we integrate disparate literatures to explain beliefs in CTM regarding COVID-19, QAnon, and voter fraud. We aim to provide a more holistic accounting, and to determine which political, psychological, and social factors are most associated with such beliefs. Using a unique national survey, we find that anti-social personality traits, anti-establishment orientations, and support for Donald Trump are more strongly related to beliefs in CTM than traditional left-right orientations or other frequently posited factors, such as education, science literacy, and social media use. Our findings encourage researchers to move beyond the traditional correlates of political behavior when examining beliefs that express anti-social tendencies or a deep skepticism of social and political institutions.
Renal intravascular shockwave lithotripsy in complex mono Ch-EVAR
Authors: Iacono G , Bressan M , Turicchia GU
Published: November 2022

Background

Our objective is to present the Peripheral Intravascular Lithotripsy (IVL) System in the treatment of calcific renal artery stenosis (RAS) during Chimney Endovascular Aneurysm Repair (Ch-EVAR). The Ch-EVAR technique is a bail out procedure in treating aortic aneurysms with challenging anatomy regarding the proximal sealing zone. RAS typically involves varying degrees of calcification, and final treatment can be fraught with risk of vessel’s damages and suboptimal results, particularly when renal angioplasty represents the only feasible course of action in Ch-EVAR.

Method

We present a case of a patient with a complex juxtarenal abdominal aortic aneurysm and a pre-obstructive chalky stenosis of the right renal artery who underwent mono ChEVAR associated to visceral Intravascular Lithotripsy shockwave angioplasty.

Conclusion

IVL is an attractive modality for the treatment of challenging, heavily calcified renal arteries that combines the calcium-disrupting capability of lithotripsy with the familiarity of balloon catheters to facilitate proper stent deployment.

Result

We propose the IVL system as an additional tool in the vascular surgeon’s armamentarium not only to obtain large-bore access to enable Transaortic Valve Replacement (TAVR) and EVAR but also to perform angioplasty of severely calcified visceral arteries during Ch-EVAR.
Surprise as an Emotion: A Response to Ortony
Authors: Neta Maital , Kim M. Justin
Published: November 2022

We write in response to an article published in this journal by Andrew Ortony titled “Are All ‘Basic Emotions’ Emotions? A Problem for the (Basic) Emotions Construct.” The author claimed that “for all its elevated status as a basic emotion, surprise fails to satisfy the minimal requirements that [he] proposed for something to be an emotion, and if it is not an emotion, it cannot possibly be a basic emotion.” Although we acknowledge the concerns brought forth by Ortony, we respectfully disagree with his conclusion about surprise. To make a case against the assertion that surprise is valence-free, we summarize an extensive body of work showing that surprise is indeed valenced—in a specific manner (i.e., ambiguously valenced)—and that it meets all of Ortony’s criteria for an emotion. In other words, rather than being described as neither positive nor negative, this emotion is either positive or negative. We consider the data with respect to surprise as a basic emotion, and we dispute the definitions of basic emotions as “widely divergent.” Future work is needed to continue defining an emotion, and a basic emotion, but we believe this is a worthy effort toward shaping a still evolving field.
Authorship disputes and patient research participation: collaborating across backgrounds
Authors: Hall Will
Published: November 2022

Public participation and survivor research in mental health are widely recognized as vital to the field. At the same time, contributions of patient collaborators can present unique challenges to determining authorship. Using an unresolved dispute around research contributions to the American Psychiatric Association’s Psychiatric Services journal, authorship and contribution are addressed. Recommendations are suggested to prevent dilemmas and achieve responsible research credit inclusion, especially among researchers with different backgrounds and asymmetric power relations. Researchers and publishers can prepare proactively for conflict through consensus on authorship criteria, prior agreements around author inclusion, arrangement for third party dispute resolution, transparency in communication and contracts, notification to prospective publications of pending disputes, a contributor-guarantor model of contribution, journal editor “expressions of concern” when authorship disputes go unresolved, and expectation of conflict as generative.
Molecular Docking and Dynamics Simulation Studies of Ginsenosides with SARS-CoV-2 Host and Viral Entry Protein Targets
Authors: Shifeng Pang , Boopathi Vinothini , Murugesan Mohanapriya , Mathiyalagan Ramya , Ahn JongChan , Xiaolin Chen , Yang Dong-Uk , Kwak Gi-Young , Kong Byoung Man , Yang Deok-Chun , Kang Se Chan , Hao Zhang
Published: November 2022

Despite the contemporary advancements in the field of science and medicine, combating the coronavirus disease 2019 (COVID-19) is extremely challenging in many aspects as the virus keeps spreading and mutating rapidly. As there is no effective and conclusive drug therapy to date, it is crucial to explore plant-based natural compounds for their potential to inhibit SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). Recent research highly focuses on screening various phytochemicals to elucidate their anti-viral efficacy. However, very few studies were published investigating the anti-viral efficacy of ginsenosides. Hence, the main aim of this study was to investigate the inhibitory potential of the available 122 ginsenosides from Panax ginseng against SARS-CoV-2-related proteins using a molecular docking and molecular dynamics approach. The major bioactive compounds “ginsenosides” of P. ginseng were docked to six vital SAR-CoV-2 host entry-related proteins such as ACE2, Spike RBD, ACE2 and Spike RBD complex, Spike (pre-fused), Spike (post-fused), and HR domain, with lowest binding energies of −9.5 kcal/mol, −8.1 kcal/mol, −10.4 kcal/mol, −10.4 kcal/mol, −9.3 kcal/mol, and −8.2 kcal/mol, respectively. Almost all the ginsenosides have shown low binding energies and were found to be favourable for efficient docking and resultant inhibition of the viral proteins. However, ACE2 has shown the highest interaction capability. Hence, the top five ginsenosides with the highest binding energy with ACE2 were subjected to MD, post MD analysis, and MM/PBSA calculations. MD simulation results have shown higher stability, flexibility, and mobility of the selected compounds. Additionally, MM-PBSA also affirms the docking results. The results obtained from this study have provided highly potential candidates for developing natural inhibitors against COVID-19.
The Longitudinal Effect of Narcissistic Admiration and Rivalry Traits on Relationship Satisfaction
Authors: Kislev Elyakim
Published: November 2022

This research estimates how changes in admiration and rivalry narcissistic traits correlate with changes in relationship satisfaction over time. Longitudinal analyses based on data from the Panel Analysis of Intimate Relationships and Family Dynamics (pairfam) studies were used to investigate this question. Findings show associations between heightening rivalry narcissistic traits and decreased levels of relationship satisfaction among men and women, and between heightening admiration narcissistic traits and decreased levels of relationship satisfaction among men. When the two aspects were estimated together, accounting for collinearity, heightening admiration narcissistic traits were not associated with changes in relationship satisfaction among men, while, among women, they correlated with increased levels of relationship satisfaction. These findings advance previous propositions in recent literature and shed light on gender differences in this regard.
Re-thinking childhood in Peru: A critical discourse analysis of Peruvian early childhood policies
Authors: Vindrola Stefania
Published: November 2022

Early childhood has become a priority in national and international political agendas. In the last decade, states have elaborated social policies and launched a variety of programmes for young children. Using Critical Discourse Analysis, this research explores the most prominent conceptualisations of children and childhood underpinning official Early Childhood policies in Peru, drawing on theoretical frameworks from childhood studies. The study identified the existence of a convergence of discourses about children and childhood in the policy documents which are based on different perspectives: developmental psychology, human capital theory and a children’s rights-based approach. From this analysis, I argue that early childhood policies in Peru evidence a developmentalist predominance that has problematic implications in the context of the country’s bicentennial anniversary of independence. I analyse how this developmental focus leads to a lack of sensitivity about the impact of cultural factors on children’s experiences and on the exercise of their rights, particularly on children’s right to participation. Finally, I argue for a rethinking of Peruvian early childhood policies and future policymaking processes using a sociological lens, in order to accomplish the State’s objective of building a post-bicentennial nation that is able to secure improvements on children’s lives and advance social justice.
The Use of a Personalized 3D Printed Model for Pre-Operative Education in Patients with Severe Periarticular Foot and Ankle Fractures
Authors: Antoniades Stephanie , Adamczyk Andrew , Nessek Hamid , Meulenkamp Brad , Karl-Andre R. Lalonde
Published: November 2022

Category:

Trauma; Other

Introduction/Purpose:

Complex periarticular foot and ankle fractures have shown to have significant psychosocial effects on patients such as developing catastrophizing behaviours and poor pain coping strategies. These factors have shown to influence patient satisfaction. Interestingly, a positive association exists between patient satisfaction and preoperative expectations being met. For patient expectations to be met, clear comprehensive preoperative education is required. 3D printing has gained popularity due to its benefits in preoperative planning as well as patient education. Our aims were to 1) investigate the impact of a personalized 3D printed model for patient education on pre- and post-operative expectations and overall satisfaction and 2) investigate the impact of this teaching modality on PROMS and their correlation to patient expectation and satisfaction.

Methods:

Twenty-eight patients presenting complex periarticular foot and ankle fractures (pilon, talus and calcaneus) were randomized to either control or intervention (3D). All patients underwent a preoperative standardized education session with or without a personalized 3D printed model. Patient expectation and satisfaction were quantified pre- and postoperatively using the MODEMS questionnaires while the following PROMs (VAS and SF-12) were assessed at 2 weeks, 3 months, 6 months and 12 months post-operatively.

Results:

No significant differences were found between groups for MODEMS pre- (p=0.329) and postoperative expectation (p=0.654), and satisfaction (p=0.411). While not statistically significant, there was a trend towards expectations being better met in the intervention group when compared to the control group (31.2% vs 43.5% respectively). Also, there were no significant differences between groups for VAS and SF-12 at different time points, expect for SF-12 at 3 months for physical component only. A strong positive correlation (0.905, p=0.013) was found between MODEMS preoperative expectation and VAS scores at 12 months in the intervention group.

Conclusion:

Although there were no significant differences found between groups for pre- and postoperative patient expectation and overall satisfaction at 12 months, there is a trend towards expectations being better met in the intervention group. This could indicate that lower and more realistic expectations are set preoperatively when educating patients using a 3D model. Expectations preoperatively are strongly correlated with pain scores at 12 months in the intervention group demonstrating an association with realistic expectations and improved pain scores when a 3D model was used. Thus, personalized 3D printed education is a non- invasive tool that may impact pain coping strategies post-operatively.
Genomic trajectories of a near-extinction event in the Chatham Island black robin
Authors: von Seth Johanna , van der Valk Tom , Lord Edana , Sigeman Hanna , Olsen Remi-André , Knapp Michael , Kardailsky Olga , Robertson Fiona , Hale Marie , Houston Dave , Kennedy Euan , Dalén Love , Norén Karin , Massaro Melanie , Robertson Bruce C. , Dussex Nicolas
Published: November 2022

Background

Understanding the micro-­evolutionary response of populations to demographic declines is a major goal in evolutionary and conservation biology. In small populations, genetic drift can lead to an accumulation of deleterious mutations, which will increase the risk of extinction. However, demographic recovery can still occur after extreme declines, suggesting that natural selection may purge deleterious mutations, even in extremely small populations. The Chatham Island black robin (Petroica traversi) is arguably the most inbred bird species in the world. It avoided imminent extinction in the early 1980s and after a remarkable recovery from a single pair, a second population was established and the two extant populations have evolved in complete isolation since then. Here, we analysed 52 modern and historical genomes to examine the genomic consequences of this extreme bottleneck and the subsequent translocation.

Results

We found evidence for two-fold decline in heterozygosity and three- to four-fold increase in inbreeding in modern genomes. Moreover, there was partial support for temporal reduction in total load for detrimental variation. In contrast, compared to historical genomes, modern genomes showed a significantly higher realised load, reflecting the temporal increase in inbreeding. Furthermore, the translocation induced only small changes in the frequency of deleterious alleles, with the majority of detrimental variation being shared between the two populations.

Conclusion

Our results highlight the dynamics of mutational load in a species that recovered from the brink of extinction, and show rather limited temporal changes in mutational load. We hypothesise that ancestral purging may have been facilitated by population fragmentation and isolation on several islands for thousands of generations and may have already reduced much of the highly deleterious load well before human arrival and introduction of pests to the archipelago. The majority of fixed deleterious variation was shared between the modern populations, but translocation of individuals with low mutational load could possibly mitigate further fixation of high-frequency deleterious variation.
Vaginal microbiota in women with spontaneous preterm labor versus those with term labor in Kenya: a case control study
Authors: Gulavi Edgar , Mwendwa Fridah , Atandi David O. , Okiro Patricia O. , Hall Michael , Beiko Robert G. , Adam Rodney D.
Published: November 2022

Background

Preterm birth is a global problem with about 12% of births in sub-Saharan Africa occurring before 37 weeks of gestation. Several studies have explored a potential association between vaginal microbiota and preterm birth, and some have found an association while others have not. We performed a study designed to determine whether there is an association with vaginal microbiota and/or placental microbiota and preterm birth in an African setting.

Methods

Women presenting to the study hospital in labor with a gestational age of 26 to 36 weeks plus six days were prospectively enrolled in a study of the microbiota in preterm labor along with controls matched for age and parity. A vaginal sample was collected at the time of presentation to the hospital in active labor. In addition, a placental sample was collected when available. Libraries were constructed using PCR primers to amplify the V6/V7/V8 variable regions of the 16S rRNA gene, followed by sequencing with an Illumina MiSeq machine and analysis using QIIME2 2022.2.

Results

Forty-nine women presenting with preterm labor and their controls were enrolled in the study of which 23 matched case–control pairs had sufficient sequence data for comparison. Lactobacillus was identified in all subjects, ranging in abundance from < 1% to > 99%, with Lactobacillus iners and Lactobacillus crispatus the most common species. Over half of the vaginal samples contained Gardnerella and/or Prevotella; both species were associated with preterm birth in previous studies. However, we found no significant difference in composition between mothers with preterm and those with full-term deliveries, with both groups showing roughly equal representation of different Lactobacillus species and dysbiosis-associated genera. Placental samples generally had poor DNA recovery, with a mix of probable sequencing artifacts, contamination, and bacteria acquired during passage through the birth canal. However, several placental samples showed strong evidence for the presence of Streptococcus species, which are known to infect the placenta.

Conclusions

The current study showed no association of preterm birth with composition of the vaginal community. It does provide important information on the range of sequence types in African women and supports other data suggesting that women of African ancestry have an increased frequency of non-Lactobacillus types, but without evidence of associated adverse outcomes.
Poly-γ-glutamic acid promoted maize root development by affecting auxin signaling pathway and the abundance and diversity of rhizosphere microbial community
Authors: Ma Haizhen , Li Panpan , Xiao Ning , Xia Tao
Published: November 2022

Background

The root systems of higher plants play an important role in plant growth and development. In our present study, it was found that poly-γ-glutamic acid (γ-PGA), an environmentally friendly biomacromolecule, significantly improved root development in maize.

Results

After treatment with γ-PGA for 7 days, the fresh weight of maize roots was significantly increased and the differences between γ-PGA treated group and control group were mainly caused by the number (higher by 71.87% compared to the control) and length of lateral roots. RNAseq and RT-PCR analyses showed that γ-PGA treatment upregulated the expression of genes related to the synthesis of auxins and auxin signal in maize roots. In addition, γ-PGA promoted the accumulation of plant growth-promoting bacteria, such as Azospirillum, Azohydromonas, Ramlibacter, and Sphingobium (Proteobacteria), Streptomyces (Actinobacteria), Parasegetibacter (Bacteroidetes), and Gemmatimonas (Gemmatimonadetes) in rhizosphere soil and the secretion of auxins. The results of this study deepened our understanding of the effects and mechanism of γ-PGA on maize root development, and as well as highlighted the possibility of using γ-PGA to improve crop growth and soil environment.

Conclusions

γ-PGA promotes early growth and development of maize roots by inducing the secretion and accumulation of auxin in roots and in rhizosphere soil, and increasing the abundance of plant growth promoting bacteria.