bluuebunny/crossref_metadata_2025 huggingface dataset:
RETRACTED ARTICLE: Exosome-transmitted miR-128-3p increase chemosensitivity of oxaliplatin-resistant colorectal cancer
Authors: Liu Tong , Zhang Xin , Du Lutao , Wang Yunshan , Liu Xiaoming , Tian Hui , Wang Lili , Li Peilong , Zhao Yinghui , Duan Weili , Xie Yujiao , Sun Zhaowei , Wang Chuanxin
Published: March 2019

Background

Oxaliplatin resistance is a major challenge for treatment of advanced colorectal cancer (CRC). Both acquisition of epithelial-mesenchymal transition (EMT) and suppressed drug accumulation in cancer cells contributes to development of oxaliplatin resistance. Aberrant expression of small noncoding RNA, miR-128-3p, has been shown to be a key regulator in tumorigenesis and cancer development. However, its roles in the progression of CRC and oxaliplatin-resistance are largely unknown.

Methods

Oxaliplatin-resistant CRC and normal intestinal FHC cells were transfected with a miR-128-3p expression lentivirus. After transfection, FHC-derived exosomes were isolated and co-cultured with CRC cells. miR-128-3p expression in resistant CRC cells, FHC cells, and exosomes was quantified by quantitative real-time PCR (RT-qPCR). The mRNA and protein levels of miR-128-3p target genes in resistant CRC cells were quantified by RT-qPCR and western blot, respectively. The effects of miR-128-3p on CRC cell viability, apoptosis, EMT, motility and drug efflux were evaluated by CCK8, flow cytometry, Transwell and wound healing assays, immunofluorescence, and atomic absorption spectrophotometry. Xenograft models were used to determine whether miR-128-3p loaded exosomes can re-sensitize CRC cells to oxaliplatin in vivo.

Results

In our established stable oxaliplatin-resistant CRC cell lines, in vitro and vivo studies revealed miR-128-3p suppressed EMT and increased intracellular oxaliplatin accumulation. Importantly, our results indicated that lower miR-128-3p expression was associated with poor oxaliplatin response in advanced human CRC patients. Moreover, data showed that miR-128-3p-transfected FHC cells effectively packaged miR-128-3p into secreted exosomes and mediated miR-128-3p delivery to oxaliplatin-resistant cells, improving oxaliplatin response in CRC cells both in vitro and in vivo. In addition, miR-128-3p overexpression up-regulated E-cadherin levels and inhibited oxaliplatin-induced EMT by suppressing Bmi1 expression in resistant cells. Meanwhile, it also decreased oxaliplatin efflux through suppressed expression of the drug transporter MRP5.

Conclusion

Our results demonstrate that miR-128-3p delivery via exosomes represents a novel strategy enhancing chemosensitivity in CRC through negative regulation of Bmi1 and MRP5. Moreover, miR-128-3p may be a promising diagnostic and prognostic marker for oxaliplatin-based chemotherapy.
Burn recidivism: a 10-year retrospective study characterizing patients with repeated burn injuries at a large tertiary referral burn center in the United States
Authors: Laughon Sarah L. , Gaynes Bradley N. , Chrisco Lori P. , Jones Samuel W. , Williams Felicia N. , Cairns Bruce A. , Gala Gary J.
Published: March 2019

Background

Psychiatric and substance use disorders are common among trauma and burn patients and are known risk factors for repeat episodes of trauma, known as trauma recidivism. The epidemiology of burn recidivism, specifically, has not been described. This study aimed to characterize cases of burn recidivism at a large US tertiary care burn center and compare burn recidivists (RCs) with non-recidivists (NRCs).

Methods

A 10-year retrospective descriptive cohort study of adult burn patients admitted to the North Carolina Jaycee Burn Center was conducted using data from an electronic burn registry and the medical record. Continuous variables were reported using medians and interquartile ranges (IQR). Chi-square and Wilcoxon-Mann-Whitney tests were used to compare demographic, burn, and hospitalization characteristics between NRCs and RCs.

Results

A total of 7134 burn patients were admitted, among which 51 (0.7%) were RCs and accounted for 129 (1.8%) admissions. Of the 51 RCs, 37 had two burn injuries each, totaling 74 admissions as a group, while the remaining 14 RCs had between three and eight burn injuries each, totaling 55 admissions as a group. Compared to NRCs, RCs were younger (median age 36 years vs. 42 years, p = 0.02) and more likely to be white (75% vs. 60%, p = 0.03), uninsured (45% vs. 30%, p = 0.02), have chemical burns (16% vs. 5%, p <  0.0001), and have burns that were ≤ 10% total body surface area (89% vs. 76%, p = 0.001). The mortality rate for RCs vs. NRCs did not differ (0% vs. 1.2%, p = 0.41). Psychiatric and substance use disorders were approximately five times greater among RCs compared to NRCs (75% vs. 15%, p <  0.001). Median total hospital charges per patient were nearly three times higher for RCs vs. NRCs ($85,736 vs. $32,023, p <  0.0001).

Conclusions

Distinct from trauma recidivism, burn recidivism is not associated with more severe injury or increased mortality. Similar to trauma recidivists, but to a greater extent, burn RCs have high rates of comorbid psychiatric and medical conditions that contribute to increased health care utilization and costs. Studies involving larger samples from multiple centers can further clarify whether these findings are generalizable to national burn and trauma populations.
Septate junction components control Drosophila hematopoiesis through the Hippo pathway
Authors: Khadilkar Rohan J. , Tanentzapf Guy
Published: March 2019

Hematopoiesis requires coordinated cell signals to control the proliferation and differentiation of progenitor cells. In Drosophila, blood progenitors, called prohemocytes, which are located in a hematopoietic organ called the lymph gland, are regulated by the Salvador-Warts-Hippo pathway. In epithelial cells, the Hippo pathway integrates diverse biological inputs, such as cell polarity and cell-cell contacts, but Drosophila blood cells lack the conspicuous polarity of epithelial cells. Here, we show that the septate-junction components Cora and NrxIV promote Hippo signaling in the lymph gland. Depletion of septate-junction components in hemocytes produces similar phenotypes to those observed in Hippo pathway mutants, including increased differentiation of immune cells. Our analysis places septate-junction components as upstream regulators of the Hippo pathway where they recruit Merlin to the membrane. Finally, we show that interactions of septate-junction components with the Hippo pathway are a key functional component of the cellular immune response following infection.
Dynamics of Wnt activity on the acquisition of ectoderm potency in epiblast stem cells
Authors: Osteil Pierre , Studdert Josh B. , Goh Hwee Ngee , Wilkie Emilie E. , Fan Xiaochen , Khoo Poh-Lynn , Peng Guangdun , Salehin Nazmus , Knowles Hilary , Han Jing-Dong J. , Jing Naihe , Fossat Nicolas , Tam Patrick P. L.
Published: March 2019

During embryogenesis, the stringent regulation of Wnt activity is crucial for the morphogenesis of the head and brain. The loss of function of the Wnt inhibitor Dkk1 results in elevated Wnt activity, loss of ectoderm lineage attributes from the anterior epiblast, and the posteriorisation of anterior germ layer tissue towards the mesendoderm. The modulation of Wnt signalling may therefore be crucial for the allocation of epiblast cells to ectoderm progenitors during gastrulation. To test this hypothesis, we examined the lineage characteristics of epiblast stem cells (EpiSCs) that were derived and maintained under different signalling conditions. We showed that suppression of Wnt activity enhanced the ectoderm propensity of the EpiSCs. Neuroectoderm differentiation of these EpiSCs was further empowered by the robust re-activation of Wnt activity. Therefore, during gastrulation, the tuning of the signalling activities that mediate mesendoderm differentiation is instrumental for the acquisition of ectoderm potency in the epiblast.
Transition state dynamics during a stochastic fate choice
Authors: Antolović Vlatka , Lenn Tchern , Miermont Agnes , Chubb Jonathan R.
Published: March 2019

The generation of multiple fates from a uniform cell population via self-organisation is a recurring feature in development and regeneration. However, for most self-organising systems, we have little understanding of the processes that allow cells to become different. One of the clearest examples of developmental self-organisation is shown by Dictyostelium, with cells segregating into two major fates, stalk and spore, within multicellular aggregates. To characterise the gene expression decisions that underlie this cell fate bifurcation, we carried out single cell transcriptomics on Dictyostelium aggregates. Our data show the transition of progenitors into prespore and prestalk cells occurs via distinct developmental intermediates. Few cells were captured switching between states, with minimal overlap in fate marker expression between cell types, suggesting states are discrete and transitions rapid. Surprisingly, fate-specific transcript dynamics were a small proportion of overall gene expression changes, with transcript divergence coinciding precisely with large-scale remodelling of the transcriptome shared by prestalk and prespore cells. These observations suggest the stepwise separation of cell identity is temporally coupled to global expression transitions common to both fates.
XMAP215 promotes microtubule–F-actin interactions to regulate growth cone microtubules during axon guidance in Xenopus laevis
Authors: Slater Paula G. , Cammarata Garrett M. , Samuelson Annika G. , Magee Alexandra , Hu Yuhan , Lowery Laura Anne
Published: March 2019

It has long been established that neuronal growth cone navigation depends on changes in microtubule (MT) and F-actin architecture downstream of guidance cues. However, the mechanisms by which MTs and F-actin are dually coordinated remain a fundamentally unresolved question. Here, we report that the well-characterized MT polymerase, XMAP215 (also known as CKAP5), plays an important role in mediating MT–F-actin interaction within the growth cone. We demonstrate that XMAP215 regulates MT–F-actin alignment through its N-terminal TOG 1–5 domains. Additionally, we show that XMAP215 directly binds to F-actin in vitro and co-localizes with F-actin in the growth cone periphery. We also find that XMAP215 is required for regulation of growth cone morphology and response to the guidance cue, Ephrin A5. Our findings provide the first strong evidence that XMAP215 coordinates MT and F-actin interaction in vivo. We suggest a model in which XMAP215 regulates MT extension along F-actin bundles into the growth cone periphery and that these interactions may be important to control cytoskeletal dynamics downstream of guidance cues.

This article has an associated First Person interview with the first author of the paper.
Feasibility of an ADC-based radiomics model for predicting pelvic lymph node metastases in patients with stage IB–IIA cervical squamous cell carcinoma
Authors: Yu Yan Yan , Zhang Rui , Dong Rui Tong , Hu Qi Yun , Yu Tao , Liu Fan , Luo Ya Hong , Dong Yue
Published: March 2019

Objectives:

To investigate the prediction value of a radiomics model based on apparent diffusion coefficient (ADC) maps for pelvic lymph node metastasis (PLNM) in patients with stage IB–IIA cervical squamous cell carcinoma (CSCC).

Methods:

A total of 153 stage IB–IIA CSCC patients who underwent preoperative MRI including DWI from January 2015 to October 2017 were retrospectively studied and divided into a training cohort ( n = 102) and a validation cohort ( n = 51). Radiomics features were extracted from the ADC maps. The one-way ANOVA method, Mann-Whitney U test and Pearson’s correlation analysis were used for selecting radiomics features. Logistic regression analyses were used to develop the model. ROC analyses were used to evaluate the prediction performance of the model.

Results:

Clinical stage, tumor diameter, and MR-reported lymph node (LN) status were significantly associated with LN status ( p < 0.05 for both the training and validation cohorts). The radiomics model, which incorporated clinical stage, MR-reported LN status, and grey-level non-uniformity, showed good predictive performance in the training group (AUC 0.864; 95% CI, 0.782 – 0.924) and the validation group (AUC 0.870; 95% CI, 0.747 – 0.948). The performance of the radiomics model was significantly better than that of each predictive factor alone.

Conclusion:

The presented radiomics model, a non-invasive preoperative prediction tool, has the potential to have more predictive efficacy than clinical and radiological factors for differentiating between metastatic and non-metastatic lymph nodes.

Advances in knowledge:

A radiomics model derived from the ADC maps of primary lesions demonstrated good performance for predicting PLNM in stage IB-IIA CSCC patients and may help to improve clinical decision-making.
Usefulness of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio as a predictor of disease-free survival in breast cancer: A cross-sectional study
Authors: Al-Bairmany Yaala S. , Aqabi Adil S. , Al-Hasnawi Farah H. , Al-Aawad Alaa S.
Published: March 2019

Background: The relationship between neutrophil-lymphocyte ratio (NLR) with outcome is a complex issue. A high NLR reflects systemic inflammation. This study aimed to estimate the relationship between NLR, and platelet-lymphocyte ratio (PLR) in disease-free survival (DFS).

Methods: This was a cross-sectional study in which we reviewed the patient files of 102 patients with breast cancer treated at the Babylon Oncology Center from January 2009 to September 2014, who had follow-up for at least 36 months. The following data were collected from patient files: age, diagnosis date, date of recurrence and/or metastasis, follow-up, histological tumor type, tumor size, node metastasis stage, histological differentiation degree, estrogen and/or progesterone receptor expression, HER2 neu status, and metastasis site.

Results: The mean age of patients was 50.4 ± 11.7 years and lowest period of follow up was 40 months. Longest DFS was 62 months, with 5 years DFS in 52.5% of patients. Stage N0 was associated with a significantly higher DFS compared to stage N1. Isolated local recurrence was seen in 15% of patients and combined local recurrences with distant metastasis was observed 37%. NLR had the highest discrimination ability to predict recurrence and distant metastasis.

Conclusion: An increase in NLR was associated with poor DFS, and it can therefore be a predictive and prognostic factor. NLR’s established prediction model warrants further investigation.
Coordinating with a “Problem Solver”
Authors: Glazer Jacob , Rubinstein Ariel
Published: March 2019

A “problem solver” (PS) is an agent who when interacting with other agents does not “put himself in their shoes” but rather chooses a best response to a uniform distribution over all possible configurations consistent with the information he receives about the other agents’ moves.

We demonstrate the special features of a PS by analyzing a modified coordination game. In the first stage, each of the other participants—who are treated as conventional players—chooses a location. The PS then receives some partial information about their moves and chooses his location. The PS wishes to coordinate with any one of the conventional players and they wish to coordinate with him but not with each other. Equilibria are characterized and shown to have different properties than those of Nash equilibria when the PS is treated as a conventional player.

This paper was accepted by Joshua Gans, business strategy.
A General Regularized Continuous Formulation for the Maximum Clique Problem
Authors: Hungerford James T. , Rinaldi Francesco
Published: March 2019

In this paper, we develop a general regularization-based continuous optimization framework for the maximum clique problem. In particular, we consider a broad class of regularization terms that can be included in the classic Motzkin–Straus formulation, and we develop conditions that guarantee the equivalence between the continuous regularized problem and the original one in both a global and a local sense. We further analyze, from a computational point of view, two different regularizers that satisfy the general conditions.
Have stoma, will fly
Authors: Arlow Jenny
Published: March 2019

Jenny Arlow, Community Specialist Stoma Nurse, recounts an ostomy awareness course for staff at Belfast International Airport and introduces a poster to help people with a stoma fly with comfort and confidence
Initial experience of a rapid-access ultrasound imaging service for inflammatory bowel disease
Authors: Grunshaw Nigel D
Published: March 2019

Background:

Ultrasound has a number of advantages as an investigative modality in inflammatory bowel disease (IBD), particularly with regard to the accessibility of the test and immediate availability of report, although it is less widely used in the UK.

Method:

A retrospective review was performed by a consultant radiologist of the initial 6 months of a rapid-access combined ultrasound-imaging clinic, run with the assistance of an IBD nurse.

Results:

The review demonstrated that 69% of examinations were performed and reported in under 14 days. As a result of ultrasound, 43% of patients underwent change in management, with 35% requiring either immediate clinical review or follow up within 1 week.

Conclusion:

Expansion of the role of the IBD nurse, together with wider adoption of ultrasound as a primary imaging modality has the potential to significantly improve patient management in Crohn's disease and ulcerative colitis.
How to close the vocabulary gap
Authors: Bromley Matt
Published: March 2019

The best way to tackle the disadvantage gap in the early years and throughout primary school is to improve children' literacy and language skills. Matt Bromley offers some practical strategies and interventions
The mosh pit – An area for excess or a place of learning?
Authors: Epp André
Published: March 2019

Spaces and places of learning are becoming more and more differentiated. Nowadays classical concert-halls are also considered as educational places. But what about other spaces where concerts take place? The article traces this question and highlights that heavy metal concerts can also be considered as settings for education processes.
‘Their song was partial; but the harmony […] suspended hell’: Intertextuality, voice and gender in Milton/Symphony X’s Paradise Lost
Authors: Bolay Jordan
Published: March 2019

I illustrate how Symphony X’s concept album retells Milton’s Paradise Lost and complicates the narrative through its use of voice and creative extrapolation, resulting in an intertextual relationship through which the album and epic influence one another’s readings, particularly with regard to gender and the biblical binary of good/evil. One of the difficulties in interpreting the album is that singer Russell Allen shifts his tone of voice to suit the mood of the song, not to denote a change in speaker. Thus, key passages that blend characters’ voices on the album further emphasize the deconstruction of good and evil introduced through the extrapolated narrative and challenge the traditional gender roles presented in the source text. I conclude that within Symphony X’s writing and performances of Paradise Lost, the combination of performative genders challenges the politics of both the source text and the album’s cultural context, i.e. that of heavy metal.
Transfuguismo legislativo entre gobierno y oposición en Guatemala
Authors: Jiménez Badillo Margarita
Published: March 2019

El transfuguismo legislativo, una de las principales fragilidades del sistema de partidos en Guatemala, propicia constantes reconfiguraciones de las relaciones de poder en el Congreso, dejando en entredicho el funcionamiento de la democracia. El objetivo de este estudio es describir en cuatro legislaturas –desde 2004– cómo el transfuguismo ha contribuido a acentuar la fragmentación del sistema de partidos en Guatemala. Se utiliza para su medición el número de legisladores tránsfugas, así como indicadores de volatilidad, fluidez y tasa de transfuguismo. Se examina la direccionalidad de la migración: al oficialismo o a los bloques de oposición en la dinámica interna del Congreso. Se sostiene que el transfuguismo agudiza la debilidad institucional en el sistema de partidos y que la alteración del tamaño de las bancadas responde a incentivos personales y/o de liderazgos, a fin de sumar mayor poder político en la arena parlamentaria.
Cambio climático y conflictividad socioambiental en América Latina y el Caribe
Authors: Stein Heinemann Alfredo
Published: March 2019

El artículo contribuye a los debates conceptuales y de políticas sobre la relación entre cambio climático, seguridad y conflicto en América Latina y el Caribe, región que experimenta una creciente vulnerabilidad ambiental y social producto de recurrentes fenómenos de clima extremo y altos niveles de inseguridad ciudadana. Se propone una tipología de conflictos generados por las desigualdades entre quienes provocan el fenómeno, quienes más lo sufren y quienes deberían asumir los costos para enfrentar sus consecuencias.
ANALISIS PENGARUH KEMAMPUAN PERUSAHAAN, DAYA RESPON RANTAI PASOK, DAN PRAKTIK MANAJEMEN RANTAI PASOK TERHADAP KEUNGGULAN BERSAING DAN KINERJA PERUSAHAAN (Studi pada Rantai Pasok Pelumas Jawa Tengah)
Authors: Kurniawan Rezky , Mangunwihardjo Suyudi , Perdhana Mirwan Surya
Published: March 2019

Penelitian ini dilakukan dengan menganalisis faktor yang mempengaruhi kinerja perusahaan dengan variabel praktik manajemen rantai pasok, daya respon rantai pasok, kemampuan perusahaan dan variabel keunggulan daya saing sebagai variabel intervening. Penelitian ini mengembangkan suatu model teoritis dengan mengajukan lima hipotesis yang akan diuji mengunakan Structural Equation Modelling (SEM) sebagai alat analisis. Responden dari penelitian ini adalah retailer pelumas Pertamina berjumlah 158 retailer yang tersebar di tujuh rayon di area Jawa Tengah dan Yogyakarta. Hasil penelitian ini menunjukkan bahwa kinerja perusahaan dapat ditingkatkan dengan praktik manajemen rantai pasok yang memadai dan keunggulan daya saing perusahaan, serta kemampuan perusahaan berpengaruh positif terhadap keunggulan daya saing perusahaan. Namun daya respon rantai pasok tidak berpengaruh positif dalam meningkatkan kinerja perusahaan.
The Existence of the Doctrine of Severability and Competence-Competence under the Constellation of Indonesian Arbitration Law
Authors: Sutanto Marko Cahya
Published: March 2019

When the parties choose Indonesia as the seat of arbitration, one might inquire whether Indonesian legal system is in conformity with the doctrines that developed in the field of international commercial arbitration. To fulfill that purpose, this paper discusses: (1) under the umbrella of severability doctrine, the agreement to arbitrate or arbitration clause is not classified as an accessory to the principal contract; and (2) the competence-competence doctrine is not adopted perfectly on the account of the question whether the tribunal can decide on its own jurisdiction is not explicitly touched.
The Use of Anthropological Approach in Municipal Strategic Planning
Authors: Liukinevičienė Laima , Vičienė Jovita
Published: March 2019

The article presents a theoretical concept of an anthropological approach in strategic municipal management as well as work of researchers in development of anthropological methodology in strategic management. Pursuing the aim to develop theoretical discourse, the results of the performed qualitative research which confirm the actuality of an anthropological approach and application possibilities in municipal strategic planning are presented.
The Impact of Corporate Cultural Behaviour on Common Stock Return: Some Implications for Corporate Governance
Authors: Senarathne Chamil W.
Published: March 2019

This paper examines the relationship between common stock return and corporate cultural behaviour of twenty listed firms from Shanghai Stock Exchange. The particular research questions of this study include: whether corporate cultural behaviour impacts common stock returns and under what conditions it impacts shareholder expectations and corporate governance.
Performative Strategien des memento mori
Authors: Schmidt Antje
Published: March 2019

In einer gesteigerten Form der Memento-mori-Dichtung des Barock wurde die menschliche Sterblichkeit durch den Einsatz performativer Strategien für die Zeitgenoss*innen bereits zu Lebzeiten erfahrbar. So waren mahnende und tröstende Tote, die scheinbar direkt aus dem Jenseits zu den Lebenden sprechen, in Begräbnisgedichten und Grabinschriften allgegenwärtig. Ebenso waren Gedichte und Sterbelieder verbreitet, in denen der Sterbeakt performativ durchlebt werden konnte. In der Gegenwart, die sich nach Norbert Elias durch eine Verdrängung der menschlichen Vergänglichkeit zugunsten von Unsterblichkeitsphantasien, und somit einer Vermeidung von Erfahrungen mit der Vergänglichkeit, auszeichnet, gestalten einige deutschsprachige Lyriker*innen moderne Variationen dieses gesteigerten memento mori. In den untersuchten Gedichten von Özlem Özgül Dündar und Günter Kunert werden durch performative Verfahren Konfrontationen mit der eigenen Endlichkeit inszeniert, welche als moderne, säkulare Vergänglichkeitsmahnungen verstanden werden können.
Aufzeichnung von Vergänglichkeit
Authors: Benthien Claudia
Published: March 2019

Dieser Beitrag untersucht eine Videoinstallation des belgischen Künstlers Koen Theys, die er als Remediation einer monumentalen skulpturalen Installation angefertigt hat. Beide Werke sind extensive zeitgenössische Auseinandersetzungen mit dem frühneuzeitlichen Vanitas-Stillleben. Sie reflektieren und exponieren dessen mediale Form und ästhetische Eigenzeit auf potenzierte Weise, indem der Prozess des ‚Aufzeichnens von Vergänglichkeit’ sowohl erlebbar gemacht als auch ironisch kommentiert wird. Wesentliche Bezüge sind dabei die kunsthistorische Tradition und die Kunstkritik der Gegenwart.
Enden und Verfliegen
Authors: Sykora Katharina
Published: March 2019

Dieser Beitrag nimmt drei Perspektiven ein. Zunächst geht es um Ikonografien der Fliege und des Totenkopfes innerhalb der Stilllebenmalerei seit der Frühen Neuzeit und um die doppelte Vergänglichkeitsmetaphorik, die aus der Kombination von Motiv und Genre resultiert. Zudem geht die Untersuchung der Frage nach, welche medialen und semantischen Verschiebungen bei dem Übertrag dieser dichten Vanitas-Konfiguration in die Fotografie entstehen. Mein Fokus liegt dabei auf den zeitgenössischen Arbeiten der amerikanischen Fotografin Paulette Tavormina und ihren zwischen 2013 und 2015 entstandenen Re-Inszenierungen historischer Stillleben-Darstellungen. Aus der motiv- und gattungsspezifischen sowie der medialen Perspektive ergeben sich schließlich Fragestellungen, die das Thema Vanitas in seiner moralisierenden wie auch zeitlichen Dimension thematisieren. So stelle ich zwei konträre Formen der Temporalität in den Stillleben mit Fliege und Totenkopf zur Diskussion: das Enden und das Sich-Verflüchtigen.
Sound Monuments
Authors: Schulze Holger
Published: March 2019

Dieser Beitrag untersucht drei Beispiele zur Überwindung von Vergänglichkeit und Endlichkeit, einer Inversion der Vanitas-Motivik, vor allem in den Klangkünsten: Wie ist es technisch möglich und kulturell zu bewerkstelligen, dem Verwehen von Klängen entgegenzuwirken? Die transhistorische Übertragungstheorie der médiologie von Régis Debray wird hierbei genutzt, um Formen und Strategien zur ‚ewigen Übertragung’ jeweils näher zu bestimmen. Ausgehend von Edisons Bewerbung des Phonographen als eines Hilfsmittels für hörbare Testamente von Verstorbenen wird die Aufführung von John Cages ORGAN 2/ASLSP in Halberstadt, das Vorhaben einer Millennium Clock der Long Now Foundation von Stewart Brand und Brian Eno sowie die Pressung der kremierten Asche eines Verstorbenen in einer Vinylschallplatte durch die Firma Andvinyly untersucht.
En camino hacia el olvido
Authors: Gómez-Montero Javier
Published: March 2019

Marías’ Romane setzen die kontingente Verfasstheit großstädtischen Lebens in Szene, indem sie das Zeitbewusstsein der Figuren in ein Spannungsverhältnis zur Unausweichlichkeit des – oft plötzlichen – Todes setzen, und dabei die Ambivalenz von Ordnung und Chaos, von Freiheit und Emanzipation in Indifferenz und Beliebigkeit überführen. Sie spiegeln heutige Formen ausgeprägter Individualität in der Großstadt, für die Vanitas zur Erscheinungsweise der als kontingent erfahrenen Selbst- und Welterfahrung wird. Der RomanMorgen in der Schlacht denk an michthematisiert solche Ambivalenzen der Kontingenz in unterschiedlichen Figurenkonstellationen. Nicht einmal die Möglichkeiten der libidinösen Befriedigung greifen noch, wie Marías’ RomanDie sterblich Verliebtenbestätigt. Vielmehr werden Konfigurationen der Vanitas in den skizzierten Rahmen rekontextualisiert, wodurch sich ein Schwinden (difuminación) von Identität, eine Aushöhlung des Subjekts, vollzieht.
Sommes-nous François?
Authors: Wodianka Stephanie
Published: March 2019

Vergänglichkeitsthematisierungen sind in den Romanen Houellebecqs omnipräsent. Doch in welchen Kontexten erscheinen sie, was ist ihre Funktion, und inwiefern sind sie mit barocken Vanitas-Szenarien vergleichbar? Im Zentrum des Aufsatzes steht die Frage, inwiefern die Vanitas-Thematisierung bei Houellebecq im Zusammenhang steht mit einer Statuszuschreibung an die Literatur – und welche Konsequenzen daraus für das Bedeutungspotential seiner Romane abzuleiten sind. Das Zusammenspiel von Vanitas-Szenarien im Werk und Vanitas-Performanz des Autors jenseits seines Werkes lässt gerade vor dem Hintergrund der frühen poetologischen Überlegungen in Gegen das Leben, gegen die Welt (1991) ein Literaturverständnis Houellebecqs hervortreten, das im politischen Sinne höchst zweifelhaft ist. Unterwerfung (2015) erweist sich als postmoderne Erbauungsliteratur, die ihren Leser irritiert mit der Frage zurücklässt, ob er sich von François emanzipieren sollte – oder ob er einfach nur liest.
Long-Lifetime and Low Latency Data Aggregation Scheduling for Wireless Sensor Network
Authors: Gayathri Easwaran , Vanitha Mohanraj , Mangayarkarasi Ramaiah , Sakthivel Ramachandran
Published: March 2019

Wireless Sensor Networks contain an incredible number of hubs with limited registering, detecting, and wireless communication capacities. These systems have been utilized as a part of a wide zone of utilizations, such as human services, contamination checking, and target-following frameworks. The dynamic clustering of sensors into bunches is a prevalent procedure to expand the system lifetime and increment adaptability. To accomplish this, in this article the sensor hubs are adjusted to ensure a long lifetime and the activities are arranged into rounds that use fixed time intervals. In the first phase, a clustering topology is found, and a group head is picked in view of the outstanding energy level. Then the cluster head screens the network energy threshold value to identify the energy drain rate of all its cluster members. In the second stage, the Long-Lifetime and Low-Latency Data Aggregation Scheduling method is used. This scheduling method assigns schedule openings to group part information parcels. Here, congestion occurrence is completely kept away from the scenario. In the third stage, an Energy-Efficient Distributed Schedule–based convention is used to keep up greatest residual energy level over the network. The experimental outcome shows the steps proposed in this article ensure an increase in the network lifetime and decrease in the energy utilization.
Prediction and Analysis of Abrasive Water Jet Machining Performance on Hybrid Composite
Authors: Vigneshwaran S. , Uthayakumar M. , Arumugaprabu V.
Published: March 2019

Hybrid polymer composites have been used in various applications because of their superior characteristics. Conventional cutting techniques in these materials produce poor quality machining because of fiber delamination and surface damage. It is also challenging to produce shapes and cuts in polymer composite materials through conventional machining. Abrasive water jet machining (AWJM) may be suitable for producing quality cuts by controlled machining process. This article investigated the AWJM of red mud–filled sisal polyester hybrid composite. The second order regression model was developed for material removal rate (MRR) and kerf taper (KT) through the experimental data. The developed model predicted the MRR and KT with minimum error at 95 % confidence level. The MRR of the hybrid composite was influenced highly by transverse speed (83.56 %) whereas the KT was influenced mostly by standoff distance (SOD, 45.66 %). Scanning electron microscope (SEM) analysis on the cut surface helps to understand the failure mechanism on AWJM.
Influence of Surface Finish on Small Punch Testing of 9Cr Eurofer-97 Steel
Authors: Richardson M. D. , Connolly S. , Gorley M. , Wynne B. P. , Surrey E.
Published: March 2019

This study investigated the effect of surface finish on the deformation behavior of Eurofer-97 steel during room-temperature small punch testing. The surface finish of specimens was varied from coarse to fine (ranging from P240-grit silicon carbide paper to a polished finish using 0.06-μm colloidal silica). Testing was conducted on 8-mm diameter by 0.5-mm-thick disks using a 1-mm-radius punch head. No significant change was observed in the elastic-plastic transition load, maximum load, displacement at maximum load, or displacement at failure. Similarly, in all cases, failure occurred in a ductile manner, yielding a dimpled fracture surface. Although friction and surface defects may influence the output of small punch tests, the effect of altering the specimen surface finish alone was negligible in this case, indicating this is not a dominant factor in small punch testing.
A clinical guide to assessing level of ego development using psychological testing
Authors: Trimboli Frank , Keenan Charles W. , Marshall Rycke L.
Published: March 2019

This article presents a clinical guide for relating psychological test findings from the Minnesota Multiphasic Personality Inventory-2 and Rorschach Technique to various levels of ego development. The original three validity and 10 clinical scales from the MMPI and a selected group of traditional determinants from the Rorschach are employed. Expected testing results from these instruments are derived from both the authors' clinical experience and the research literature. These results are presented along a continuum of nine levels of ego development and their associated disorders. The nine levels of ego development are “normal” neurotic, neurotic trait, and neurotic symptom organization; high-, mid-, and low-level borderline organization; and affective, cognitive-affective, and cognitive psychotic organization. The relationships between typical testing responses and indices of personality functioning at each level of ego development would hopefully facilitate accurate diagnosis, which in turn would result in more effective treatment planning.
The effects of exposure on the generalization of habituation on multiple indices of disgust
Authors: Tsao Steven D. , McKay Dean
Published: March 2019

Examination of habituation to disgust-related stimuli has received limited experimental investigation. In this study, 38 undergraduates were divided into two groups. The vomit-blood (VB) group was first exposed to a realistic approximation of vomit and allowed to habituate to this stimulus, while the blood-vomit (BV) group was first allowed to habituate to a realistic approximation of blood. Following the habituation phase, each group underwent a short exposure to the unexposed stimuli (blood in the VB group, vomit in the BV group). Physiological and self-report assessments were collected during exposure. Self-report habituation was observed for both groups. In addition, only muscle tension at the levator labii and heart rate in the VB group demonstrated significant changes that could be interpreted as habituation. Consistent with previous literature, muscle tension at the levator labii appeared to be a unique indicator of disgust responding. Implications and suggestions for future research are discussed.
DIAGNOSIS OF ENDOCRINE DISEASE: IgG4-related thyroid autoimmune disease
Authors: Rotondi Mario , Carbone Andrea , Coperchini Francesca , Fonte Rodolfo , Chiovato Luca
Published: March 2019

IgG4-related disease (IgG4-RD) is fibro-inflammatory, immune-mediated, systemic disease recognized as a defined clinical condition only in 2001. The prevalence of IgG4-RD is 6/100 000, but it is likely to be underestimated due to insufficient awareness of the disease. The diagnostic approach is complex because of the heterogeneity of clinical presentation and because of rather variable diagnostic criteria. Indeed, high concentrations of IgG4 in tissue and serum are not a reliable diagnostic marker. The spectrum of IgG4-RD also includes well-known thyroid diseases including Riedel’s thyroiditis, Hashimoto’s thyroiditis and its fibrotic variant, Graves’ disease and Graves’ orbitopathy. Results from clinical studies indicate that a small subset of patients with the above-mentioned thyroid conditions present some features suggestive for IgG4-RD. However, according to more recent views, the use of the term thyroid disease with an elevation of IgG4 rather than IgG4-related thyroid diseases would appear more appropriate. Nevertheless, the occurrence of high IgG4 levels in patients with thyroid disease is relevant due to peculiarities of their clinical course.
Residual Heterozygosity and Epistatic Interactions Underlie the Complex Genetic Architecture of Yield in Diploid Potato
Authors: Marand Alexandre P , Jansky Shelley H , Gage Joseph L , Hamernik Andy J , de Leon Natalia , Jiang Jiming
Published: March 2019

Marand et al. use a high-resolution recombination map to dissect the genetic components of yield in diploid potato. Regions of recalcitrant heterozygosity in the inbred parent co-localized with elevated recombination rates, signatures of selection, and tissue-specific gene expression...

Deconvolution of the genetic architecture underlying yield is critical for understanding bases of genetic gain in species of agronomic importance. To dissect the genetic components of yield in potato, we adopted a reference-based recombination map composed of four segregating alleles from an interspecific pseudotestcross F1 potato population (n = 90). Approximately 1.5 million short nucleotide variants were utilized during map construction, resulting in unprecedented resolution for an F1 population, estimated by a median bin length of 146 kb and 11 genes per bin. Regression models uncovered 14 quantitative trait loci (QTL) underpinning yield, average tuber weight, and tubers produced per plant in a population exhibiting a striking 332% average midparent-value heterosis. Nearly 80% of yield-associated QTL were epistatic, and contained between 0 and 44 annotated genes. We found that approximately one-half of epistatic QTL overlap regions of residual heterozygosity identified in the inbred parental parent (M6). Genomic regions recalcitrant to inbreeding were associated with an increased density of genes, many of which demonstrated signatures of selection and floral tissue specificity. Dissection of the genome-wide additive and dominance values for yield and yield components indicated a widespread prevalence of dominance contributions in this population, enriched at QTL and regions of residual heterozygosity. Finally, the effects of short nucleotide variants and patterns of gene expression were determined for all genes underlying yield-associated QTL, exposing several promising candidate genes for future investigation.
Percepción del paciente crítico sobre los comportamientos de cuidado humanizado de enfermería
Authors: Joven Zuli Milena , Guáqueta Parada Sandra Rocio
Published: March 2019

Objetivo: describir la percepción del paciente crítico adulto sobre los comportamientos de cuidado humanizado de enfermería en la unidad de cuidado intensivo (UCI) adulto en un hospital de III nivel de Bogotá, Colombia.Metodología: estudio descriptivo con abordaje cuantitativo, se utilizó el instrumento “Percepción de comportamientos de cuidado humanizado de enfermería 3ª versión”, el cual cuenta con validez facial, de contenido y de constructo. Se aplicó a 55 pacientes hospitalizados en UCI, entre junio y octubre de 2016.Resultados: la percepción global del grupo obtenida fue de 83,39 en la escala estandarizada. En la categoría Priorizar el sujeto de cuidado, siempre obtuvo una calificación del 60 %, casi siempre 14 %, algunas veces 22 % y nunca 4 %. En la categoría Apertura a la comunicación para proporcionar educación en salud a la persona se tuvieron resultados favorables: 42 % para siempre, casi siempre 24 %, algunas veces 25 % y 9 % nunca. Por último, en la categoría Cualidades del hacer de enfermería se encontró que 27 % siempre percibe estos comportamientos, casi siempre 35 %, algunas veces 24 % y 14 % nunca.Conclusión: de acuerdo con los hallazgos, los comportamientos de cuidado humanizado se perciben globalmente como buenos, y en la categoría Priorizar el sujeto de cuidado se obtuvo el mayor puntaje de satisfacción por parte del paciente.
Competencia cultural de enfermeras en salud pública con población indígena
Authors: Orozco Castillo Magda Liliana , López-Díaz Alba Lucero
Published: March 2019

Objetivo: identificar elementos de competencia cultural (CC) en las enfermeras en salud pública (ESP) cuando cuidan a población indígena emberá-chamí.Metodología: etnografía interpretativa con observación participante y entrevistas en profundidad a diez colaboradores.Análisis de datos basado en la propuesta de Leininger con apoyo de los programas ATLAS.ti y Excel.Resultados: el patrón cultural permite identificar la capacidad de las esp para analizar su propia cultura, conocer, comprender e interactuar con la cultura del indígena y mediar a través de comunicación caracterizada por empatía, adaptación del lenguaje verbal y no verbal que evidencian respeto por la singularidad indígena, en un contexto de armonía con laspolíticas institucionales basadas en la cultura indígena.Conclusión: la CC de esp es un proceso amplio, tanto de ESP con la comunidad como de la articulación con políticasinstitucionales para atender la cosmovisión indígena.
O acompanhante do paciente oncológico em fase terminal: percepção do técnico de enfermagem
Authors: Bernardes Juliana Felipelli , Nolasco Frederico Francisco , Jardim Alessandra Silva Lima , Cunha Genilton Rodrigues , Takeshita Isabela Mie , Barroso Renata Adriana de Araújo
Published: March 2019

Objetivo: compreender a percepção dos técnicos de enfermagem em relação aos acompanhantes dos pacientes oncológicos em fase terminal.Metodologia: trata-se de uma pesquisa descritivo-exploratória de natureza qualitativa, desenvolvida em um hospital referência para o tratamento do câncer em Belo Horizonte, Minas Gerais. A coleta de dados ocorreu entre os meses de setembro e outubro de 2016. Utilizou-se a Análise de Conteúdo fundamentada em Bardin para a avaliação das entrevistas.Resultados: a partir da análise das entrevistas, emergiram duas categorias empíricas: O conviver cotidiano do técnico de enfermagem e o acompanhante do paciente oncológico em fase terminal e Fatores dificultadores da interação da enfermagem com os acompanhantes, focando-se na interação dos profissionais com o acompanhante e os fatores de conflito entre as partes.Conclusão: foi evidenciada a importância do acompanhante pelo técnico de enfermagem nesse processo de terminalidade, na medida em que podem proporcionar segurança e acolhimento ao paciente. No entanto, a ausência de uma comunicação adequada entre os acompanhantes e o profissional foi o fator preponderante na geração de conflitos. A enfermagem requer, por parte da instituição assim como do acompanhante, de espaços nos quais possam expressar suas angústias e anseios, fazendo que esse percurso seja um momento de acolhimento e de criação de vínculos entre os envolvidos.
RISK FACTORS OF PREECLAMPSIA IN ANUTAPURA GENERAL HOSPITAL PALU CITY
Authors: Rosmala Nur , Rahman Abd. , Dewi Nila Sintya , Aras Nurul Fitria , . Pitriani
Published: March 2019

Preeclampsia is one of the main causes of maternal and fetal mortality and morbidity. The purpose of this study was to determine the risk factors for preeclampsia in pregnant women at Anutapura Hospital Palu. This study was observational analytic with a case control approach. The case subjects were pregnant women who experienced preeclampsia and the control group were pregnant women who did not experience preeclampsia. Case samples were 112 and control 112 with matching age. Sampling is done by purposive sampling technique. Data sources used secondary data, medical records 2017. The results showed that parity (OR = 3,389 and CI = 1,936-5,934), complete antenatal care (OR = 4,012 and CI = 2,293-7,020), history of hypertension (OR = 5,071 and CI = 2,819-9,120) is a risk factor for preeclampsia in pregnant women. To overcome the incidence of preeclampsia antenatal care is expected to be more active in providing information about pregnancies that are at high risk of developing preeclampsia in pregnant women.
The role of astrocytes on the effects of exercise on episodic memory function
Authors: Loprinzi PD
Published: March 2019

This review discusses the potential role that glial cells may play in influencing the relationship between exercise and episodic memory function. A narrative review methodology is employed. Herein, the different types of glial cells, their implications in subserving episodic memory function, and how exercise can modulate glial cell activity, particularly astrocyte functionality, are discussed. Although additional experimental work is needed, astrocytes appear to play an important role in the exercise–memory interaction. Exercise may increase astrocytic size, attenuate astrogliodegeneration, improve astrocytic aquaporin-4 expression, and increase astrocytic transporter levels. These effects, in turn, may help to increase the number of synapses that neurons form, increase the number of synaptic structures, and increase presynaptic function and postsynaptic receptor localization. Ultimately, these effects may help influence long-term potentiation and episodic memory function.
Varejo de luxo: A influência dos trajes usados por clientes na qualidade do atendimento
Authors: Franco Fabiana Pacheco , Prado Rejane Alexandrina Domingues Pereira do , Silva Kelly Aparecida
Published: March 2019

Um atendimento personalizado é um diferencial para a geração de valor e a fidelização do cliente, mas muitas vezes o preconceito frente a vestimenta do comprador pode ser um empecilho para que isso aconteça. O presente estudo é do tipo descritivo com abordagem qualitativa e investiga o preconceito no atendimento oferecido por lojas de varejo de luxo em função do traje usado pelos clientes. A coleta de dados consistiu na ação de dois clientes espiões, ora bem vestidos, ora malvestidos, que visitaram e relataram o atendimento de seis lojas luxuosas em uma cidade localizada no interior de Minas Gerais. Os resultados inferem que o preconceito é maior em relação ao atendimento às mulheres. Notou-se que quando a cliente espiã estava malvestida os vendedores atendiam por obrigação e sem demonstração de simpatia ou vontade de vender os produtos. Quando bem vestida havia preocupação dos vendedores em todos os aspectos, procurando deixa-la à vontade e mostrando todos os produtos possíveis. Com o cliente espião do gênero masculino observou-se a preocupação quanto a forma de pagamento e demonstração de roupas da promoção, quando malvestido. Quando bem vestido, não se preocuparam com formas de pagamento e mostravam vários produtos sem distinção de preços.