bluuebunny/crossref_metadata_2025 huggingface dataset:
Pooled Analysis of Clinical Trials Investigating the Pharmacokinetics (PK) of Ultra-rapid Insulin BioChaperone Lispro (BCLIS) vs. Lispro (LIS) in Subjects with Type 1 (T1D) and Type 2 (T2D) Diabetes
Authors: HEISE TIM , RANSON AYMERIC , GAUDIER MARTIN , SOULA OLIVIER , ALLUIS BERTRAND , ZIJLSTRA ERIC , GLEZER STANISLAV , MEIFFREN GRÉGORY
Published: June 2018

BCLIS is an ultra-rapid insulin lispro formulation designed to accelerate the time-action profile vs. conventional short-acting insulin analogs. PK characteristics of single doses of BCLIS and LIS were characterized in four randomized, double-blind, crossover studies in altogether 112 T1D and 51 T2D subjects who received BCLIS and LIS (0.2 U/kg in studies 1 and 2, individualized doses in studies 3 and 4) subcutaneously by syringe. Insulin absorption was consistently faster with BCLIS than with LIS as indicated by reaching early half-maximum insulin levels (early t50%max) 8.4 (95% confidence interval [-9.6;-7.2]) and time to maximum levels (tmax) 10.0 [-14.3;-5.8] min earlier (p<0.0001 for both comparisons). Early insulin exposure was significantly greater for BCLIS for up to 2 hours after administration (Figure). BCLIS also showed faster offset of exposure, with a 22.3 [-28.8;-15.7] min earlier time to late half-maximum insulin levels (late t50%max) (p<0.0001) and a 24% lower late exposure (AUC2-6h; Figure). Total exposure (AUC0-6h) was similar for both formulations in all studies (treatment ratio in pooled analysis 0.99 [0.95;1.03], p=NS).

In conclusion, BCLIS consistently shows faster onset and offset of exposure than conventional LIS in both T1D and T2D.

Disclosure

T. Heise: Research Support; Self; ADOCIA, Boehringer Ingelheim GmbH, Dance Biopharm, Eli Lilly and Company, Janssen Research & Development, MedImmune, Merck Sharp & Dohme Corp., Mylan, Nordic Bioscience, Novo Nordisk A/S, Poxel SA, Roche Diagnostics Corporation, Saniona, Sanofi, Senseonics, Zealand Pharma A/S. Advisory Panel; Self; Novo Nordisk A/S, Mylan. Speaker's Bureau; Self; Dexcom, Inc., Eli Lilly and Company, Novo Nordisk A/S, Sanofi. A. Ranson: Employee; Self; ADOCIA. Stock/Shareholder; Self; ADOCIA. M. Gaudier: Employee; Self; ADOCIA. Stock/Shareholder; Self; ADOCIA. O. Soula: Board Member; Self; ADOCIA. Stock/Shareholder; Self; ADOCIA. Employee; Spouse/Partner; ADOCIA. B. Alluis: None. E. Zijlstra: Speaker's Bureau; Self; Novo Nordisk A/S. Other Relationship; Self; Novo Nordisk A/S. S. Glezer: Stock/Shareholder; Self; Sanofi. Stock/Shareholder; Spouse/Partner; Sanofi. Employee; Self; ADOCIA, Novo Nordisk Inc.. Employee; Spouse/Partner; Pfizer Inc., Teva Pharmaceutical Industries Ltd.. Stock/Shareholder; Spouse/Partner; Teva Pharmaceutical Industries Ltd. G. Meiffren: Employee; Self; ADOCIA. Stock/Shareholder; Self; ADOCIA.
Global Diabetes Prevention Interventions: A Systematic Review and Network Meta-analysis of the Real-World Impact on Incidence, Weight, and Glucose
Authors: Galaviz Karla Ivette , Weber Mary Beth , Straus Audrey , Haw Jeehea Sonya , Narayan K.M. Venkat , Ali Mohammed Kumail
Published: June 2018

OBJECTIVE

Understanding the real-world impacts of lifestyle modification (LSM) for diabetes prevention is imperative to inform resource allocation. The purpose of this study was to synthetize global evidence on the impact of LSM strategies on diabetes incidence and risk factors in one parsimonious model.

RESEARCH DESIGN AND METHODS

PubMed, Embase, Cochrane Library, and ClinicalTrials.gov were searched for studies published between January 1990 and April 2015. Effectiveness/translation studies of any design testing LSM strategies, targeting high-risk populations (with prediabetes or diabetes risk factors), and reporting diabetes incidence, weight, or glucose outcomes were included. We extracted number of diabetes cases/incidence rates and mean changes in weight (kg), fasting blood glucose (FBG, mmol/L), 2-h postload glucose (mmol/L), and hemoglobin A1c (%). Pairwise random-effects and frequentist random-effects network meta-analyses were used to obtain pooled effects.

RESULTS

Sixty-three studies were pooled in the meta-analysis (n = 17,272, mean age 49.7 years, 28.8% male, 60.8% white/European). In analyses restricted to controlled studies (n = 7), diabetes cumulative incidence was 9% among intervention participants and 12% among control participants (absolute risk reduction 3%; relative risk 0.71 [95% CI 0.58, 0.88]). In analyses combining controlled and uncontrolled studies (n = 14), participants receiving group education by health care professionals had 33% lower diabetes odds than control participants (odds ratio 0.67 [0.49, 0.92]). Intervention participants lost 1.5 kg more weight [−2.2, −0.8] and achieved a 0.09 mmol/L greater FBG decrease [−0.15, −0.03] than control participants. Every additional kilogram lost by participants was associated with 43% lower diabetes odds (β = 0.57 [0.41, 0.78]).

CONCLUSIONS

Real-world LSM strategies can reduce diabetes risk, even with small weight reductions.
Pelatihan Pengembangan Instrumen Tes Mata Pelajaran Matematika SMP
Authors: Prabowo Anggit , Kusdinar Uus , Rahmawati Uki
Published: June 2018

Tujuan pengabdian kepada masyarakat ini adalah memberikan pelatihan kepada guru matematika SMP untuk mengembangkan instrumen tes matematika SMP. Peserta pelatihan ini terdiri atas 12 guru dari 4 sekolah yaitu SMP Muhammadiyah 1 Godean, SMP Muhammadiyah 1 Gamping, SMP Muhammadiyah 1 Minggir, dan SMP Muhammadiyah 2 Depok, Kabupaten Sleman, Daerah Istimewa Yogyakarta. Kegiatan ini dilaksanakan di SMP Muhammadiyah 1 Godean. Metode pelaksanaan kegiatan pengabdian adalah melalui ceramah, diskusi, dan proyek. Pada kegiatan ceramah pemateri meyampaikan materi tentang teknik penambangan instrumen penilaian sesuai dengan prosedur yang baku dilanjutkan dengan diskusi. Setelah diskusi, peserta pelatihan megerjakan tugas proyek berupa menyusun instrument tes mata pelajaran matematika SMP, menganalisis secara kualitatif, mengujicobakannya, dan menganalisis berdasar data empirik. Melalui pelatihan ini peserta memeroleh keterampilan dalam mengembangkan instrument penilaian tes matematika SMP. Kegiatan ini telah menghasilkan perangkat instrument tes pilihan ganda untuk mata pelajaran matematika SMP untuk materi perbandingan, bangun datar, dan   hubungan antar sudut yang terstandar.
ON THE QUESTION OF FISHERY REGIME REGULATION IN THE VOLGA-CASPIAN BASSIN (ASTRAKHAN REGION) BY THE EXAMPLE OF NORTH-CASPIAN ROACH
Authors: Barabanov Vitaliy Victorovich , Nikiforov Sergey Yurievich
Published: June 2018

The article shows the assessment of fishing conditions of roach catches (the number of fishing grounds, fishing gears, catches, catches per unit of fishing effort, fishing intensity, etc.) at the main fishery objects of the Volga delta. There has been made the analysis of structure of size and gender composition of roach from commercial and amateur catches. The results have shown a depression of the population with negative dynamics in future. There have been determined main negative factors affecting the state of roach stock: unfavorable hydrological regime, incoordination in terms of commercial and amateur catches, limits of catch and size. In such circumstances the major purpose is to create a fishing regime, when maximum pass of fish spawners to spawning grounds is provided. The article proposes organizing a special regime of fishing roach with the aim to introduce additional limitations to the commercial fish catch, the main point of which is a transition from fine-meshed seines to medium-meshed seines in the day, when the water level in the Astrakhan region achieves an index mark as 350 cm. This measure will allow assuring a maximum pass of roach spawners to spawning grounds. A similar interdiction must be valid for amateur fishing. It should be noted that this interdiction is a provisional measure allowing to preserve and reproduce roach population.
NATURAL REPRODUKTION OF SILVER CARP CARASSIUSAURATUSGIBELIO (BLOCH, 1782) IN THE LOWER REACHES OF THE VOLGA RIVER IN 2012-2013
Authors: Mukhanova Raigul Sadikhovna , Vasilchenko Olga Mikhailovna , Grozesku Yulia Nikolaevna
Published: June 2018

Observation of spawning of carp sires and fattening of larvae and fry in 2012-2013 was carried out by the staff of the Laboratory of Fish Reproduction Federal state scientific institution "CaspNIRKh" from April to July on the spring floods in the lower reaches to the Volga river, in the west part: in Gandurinski, Chief, Kirov banks; in the east: in Belinsky and Vasilevsky banks, using research vessels and cars. The studies took place on the spawning grounds of the lower reaches of the Volga. Estimation of carp juvenile abundance was conducted according to the results of registration survey of juveniles in the hollow period of flood water on the spawning grounds of the western and eastern parts of the Delta. Depending on the area of the studied reservoir there were selected at least 5 samples at different sites. The catch of carp juveniles was carried out with a 6-meter scraper made of sprat net with a rare gas bag. Hydrological parameters were provided by the researchers of the Laboratory of water problems and toxicology, Federal state scientific institution "CaspNIRKh". The reliable research data assert that more favourable conditions for crucian carp breeding were formed in 2013. The duration of flooding and spawning had a positive impact on the natural reproduction of carp. Low water level in the delta front and overgrowing of water bodies in recent years contribute to creation of favorable conditions for silver carp spawning, survival of juveniles, availability of food and increase in their number. In high water year of 2013 average weight and length of juveniles was higher in all locations, compared to 2012. In 2013 in all the spawning grounds under study a large proportion of crucian carp juveniles (84.09%) was characterized by viability (F and G stages), whereas in 2012 in the spring floods of the upper zone of the eastern part of the Volga the early larvae of stage C were registered. In 2013 on the spawning grounds of the Delta the average concentration of juveniles of crucian (33.4 thousand sp/ha) and abundance of juvenile carp were higher, compared to 2012 (2.1 and 2.6 times, accordingly).
TO THE QUESTION OF STOCKING OF KAZAKHSTAN WATER BODIES BY FISH STOCKING MATERIAL OF VALUABLE FISH SPECIES
Authors: Asylbekova Saule Zhangirovna , Isbekov Kuanysh Baibulatovich , Kulikov Evgeniy Vyacheslavovich
Published: June 2018

Rational use of fish stocks in fishing reservoirs impliesa substantiated strategy of stocking water bodies by valuable fish juveniles. In reservoirs used for commercial fishing, ichthyofauna has a property of self-reproducing: in the process of natural spawning of fish there occurs further replenishment of fish abundance. Under intensive fishing and unstable hydrological regime ability of populations for self-reproduction is violated, so in order to maintain a sustainable fish population, measures are required to support fish populations. For this purpose, there is carried out stocking of natural reservoirs where commercial fishing is conducted. At present, the stocking of Kazakhstan fishery reservoirs is mainly carried out by larvae and fingerlings of carp and carnivorous fishes, giving a small commercial return. The analysis of results of the current practice and operating system of fish stocking by valuable fish juveniles shows its inefficiency. It is recommended to take into account the feeding area for a specific species, the biomass of the components of the food base used by this species, the survival at specific age stages of the invader when determining the amount of stocking. There have been proposed measures to increase stocking effectiveness, defined the age stages and principles of selecting producers to obtain fish planting material. For stocking, the genetic diversity of the producers is important, so the breeding stocks in hatcheries should be constantly replenished by wild producers. There has been stated the need of complete separating reproducing and commercial fishery, as well as for the rights of stocking for a particular user (a reservoir tenant), depending on the distributed catch quota. There are shown examples of calculating required stocking material for stocking a water reservoir with sazan and for using residual food supply (stocking Lake Balkhash by grass carp and the Ust-Kamenogorsk water reservoir by ripus).
Recognition and Reinforcement of Customary Law Community Association and their Rights over Land and Forest in West Nusa Tenggara Province
Authors: Arba Sh. M. Hum
Published: June 2018

This study aims to analyze recognition and reinforcement of customary law community association and their rights over land and forest in West Nusa Tenggara Province because in this region there are still numerous customary law community associations and their jurisdictions that are always owned, controlled, and done for generations. This study is categorized as a normative study that refers to applicable norms and legal concepts (Indonesian positive law) and reality based on the results of the study. The approaches implemented in the study are legislation approach, conceptual approach, and historical approach. This study was conducted by listing the norms of positive law and then confronting the reality which occurs in the society. It can be concluded that the recognition and reinforcement of the right of customary law community over land and forests in the Constitution and legislation is clear and decisive, however the implementation of recognition and reinforcement of customary law community association and their rights in West Nusa Tenggara Province has not been implemented by the government.
Corruption and FDI Inflows: Evidence from India and China
Authors: Hasan Munir , Rahman Mohd Nayyer , Iqbal Badar Alam
Published: June 2018

Foreign Direct Investment (FDI) is considered to be influenced not only by quantitative factors but also by qualitative factors. However, the present literature related to FDI focus more on quantitative factors rather than qualitative factors. One reason is that FDI is itself based on a quantitative benchmark (10% or more investment in equity). The qualitative factors that are related to FDI are governance, democracy, human development index etc. In the present study an endeavor is made to understand that how corruption influence FDI decision. FDI is taken in terms of percentage of GDP and Corruption is represented by Corruption Perception Index. The sample period of the study is from 1995 to 2014.
Semantic representation of similes (based on the Ukrainian, English and Polish languages).
Authors: Oleniak Mariana
Published: June 2018

Since simile in this paper is understood as a figure of speech in which two essentially unlike things are compared and not only as a construction corresponding to the formula X is like Y, the borderline between the semasiological (from form to content) and onomasiological (from content to form) approaches in respect to the analysis of simile is considered to be crucial. The article is devoted to the analysis of the existing formulas for simile that enumerate the elements in the surface structures of most similes and to the elaboration of a formula that would reflect the essence of the relationship of simile elements regardless of their formal expression. Taking into account existing linguistic studies of similes as well as the author’s own understanding of the problem, simile components are described which also have a symbolic reflection in the aforementioned universal formula for similes. Employing the method of conceptual analysis as well as the methods of description and interpretation, modelling and coding, the author devises a new formula for simile, representing all four of its constituents (a tenor, a vehicle, a comparison marker and a commonly shared salient feature). The devised formula is further subjected to analysis for the possibility of being applied to all formal types of simile. The presented formula of a universal character is essential to identify and analyse different types of similes without limiting research to the formations of a certain model. The formula is labelled universal because it characterizes similes regardless of their forms and languages in which they are used.
Acquisition of meaning in bilingual children: Interference, translation and errors
Authors: Klapicová Edita Hornáčková
Published: June 2018

Even though the process of the acquisition of phonology and syntax in bilingual children resembles that of monolinguals, vocabulary acquisition in bilingual children heavily depends on the input in each language. Bialystok (2004, p. 66) holds that “it may be that the acquisition of syntax and phonology is adequately triggered by exposure to the language, but vocabulary needs to be learned”. Children appear to have the capacity for acquiring more than the basic volume of vocabulary necessary for one language system. The aim of the present paper is to examine the following aspects: the processes of the acquisition of meaning; the manifestation of interference, transfer and borrowing; the task of finding translation equivalents; errors in vocabulary usage in bilingual children.
El gusto de los pesticidas en el vino: con una pequeña guía para reconocer el gusto de los pesticidas en el vino
Authors: Alonso-González Pablo , Parga-Dans Eva
Published: June 2018

Entrada la tarde, en una sala de piedra vieja de Mas del Rivet, en Provence, dos docenas de profesionales del vino se reúnen para una experiencia inédita de descubrimiento del gusto de los pesticidas en cata a ciegas. Las manos se dirigen hacia los vasos, las miradas se cruzan y se cuestionan, los efluvios de los vinos blancos, uno biológico, el otro no, rocían las narices conocedoras. Las muestras de los pesticidas encontrados en el vino convencional y diluidas en el agua esperan para ser comparadas en el agua en una segunda línea - cada uno les lanza ya una mirada sospechosa - pero por ahora los catadores huelen, prueban y comparan ambos vinos. Se hace un silencio pesado, en el que resuena una exclamación conjunta (Douzelet y Séralini, 2018: 15; todas las traducciones de citas literales por los autores).
SOLUTIONS TO PROMOTE LINKAGES BETWEEN ACADEMY AND INDUSTRIES FROM INNOVATION SYSTEM APPROACH
Authors: Phạm Hồng Trang , Pham Hong Nhung
Published: June 2018

The linkage between research areas and industries has brought many benefits to the socio-economic development of a country. In Vietnam, although the mechanism of autonomy in science and technology (S &T) has been established, this linkage is not strong enough. There are many objective and subjective reasons that hinder the formation and development of linkages between research areas and industries. Based on the survey of 4 universities and 4 institutes in the North of Vietnam, the article analyzes the negative factors which affect to the linkage, thus suggesting some  solutions for that.

Accordingly, industries play a central role, as investors as well as consumers of S & T products; S & T activities of the universities, institutes apart from the objective of strengthening their self-capacity will mainly serve the needs of industries; The Government plays a supporting role, ensuring the linkage by legal system and also involved in the linkage through public-private partnership process.
Adaptive implicit finite difference method for natural gas pipeline transient flow
Authors: Wang Peng , Yu Bo , Han Dongxu , Li Jingfa , Sun Dongliang , Xiang Yue , Wang Liyan
Published: June 2018

The implicit finite difference method is one of the most widely applied methods for transient natural gas simulation. However, this implicit method is associated with high computational cost. To improve the simulation efficiency of implicit finite difference method, an adaptive strategy is introduced into the simulation process. The proposed adaptive strategy consists of the adaptive time step strategy and the adaptive spatial grid strategy. And these two parts are implemented based on the local error technique and the multilevel grid technique respectively. The results illustrate that the proposed adaptive method can automatically and independently adjust the time step and the spatial grid system according to the gas flow state in the simulation process, and demonstrates a significant advantage in terms of computational accuracy and efficiency compared with the non-adaptive method.
Patient-Reported Outcome Measures Used for Neck Disorders: An Overview of Systematic Reviews
Authors: Bobos Pavlos , MacDermid Joy C. , Walton David M. , Gross Anita , Santaguida P. Lina
Published: June 2018

Background

The evaluation of patient-reported outcome measures for the neck from multiple systematic reviews will provide a broader view of, and may identify potential conflicting or consistent results for, their psychometric properties.

Objectives

The purpose of this study was to conduct an overview of systematic reviews and synthesize evidence to establish the current state of knowledge on psychometric properties of patient-reported outcome measures for patients with neck disorders.

Methods

In this overview of systematic reviews, an electronic search of 6 databases (MEDLINE, Embase, CINAHL, ILC, the Cochrane Central Register of Controlled Trials, and LILACS) was conducted to identify reviews that addressed at least one measurement property of outcome measures for people with neck pain. Only systematic reviews with patient-reported outcome measures were included in the analysis. Risk of bias was assessed with A MeaSurement Tool to Assess systematic Reviews (AMSTAR). Data on measurement properties were extracted from each systematic review.

Results

From 13 systematic reviews, 8 patient-reported outcome measures were evaluated in 2 or more reviews. Risk-of-bias scores ranged from moderate (5–7) to high (4 and lower). Findings on internal consistency, test-retest reliability, construct validity, responsiveness to change, and content and structural validity were synthesized for the Neck Disability Index (NDI) in 11 systematic reviews; the Northwick Park Neck Pain Questionnaire and Neck Pain and Disability scale (NPDS) in 6 systematic reviews; the Copenhagen Neck Functional Disability Scale in 5 systematic reviews; the Neck Bournemouth Questionnaire in 4 systematic reviews; the Core Neck Pain Questionnaire and Patient-Specific Functional Scale in 3 systematic reviews, and the Whiplash Disability Questionnaire in 2 systematic reviews.

Conclusion

High-quality evidence was found of good to excellent internal consistency and moderate to excellent test-retest reliability for the NDI. Moderate-quality evidence was found of good to excellent internal consistency and good test-retest reliability for the Northwick Park Neck Pain Questionnaire. High-quality evidence was found of excellent test-retest reliability and good to strong construct validity with pain scales for the Copenhagen Neck Functional Disability Scale. Moderate-quality evidence was found of unclear to excellent internal consistency and moderate to strong concurrent associations with the NDI and global assessment of change for the Neck Pain and Disability scale. Moderate-quality evidence was found of excellent internal consistency for the Whiplash Disability Questionnaire and of high test-retest reliability for the Patient-Specific Functional Scale. J Orthop Sports Phys Ther 2018;48(10):775–788. Epub 22 Jun 2018. doi:10.2519/jospt.2018.8131
How Do Novice Runners With Different Body Mass Indexes Begin a Self-chosen Running Regime?
Authors: Bertelsen Michael Lejbach , Hansen Mette , Rasmussen Sten , Nielsen Rasmus Oestergaard
Published: June 2018

Background

Overweight and obese novice runners are subjected to a higher load per stride than their normal-weight peers. Do they reduce their running dose accordingly when beginning a self-chosen running regime?

Objectives

To describe and compare the preferred running dose in normal-weight, overweight, and obese novice runners when they commence a self-chosen running regime.

Methods

In this exploratory, 7-day prospective cohort study, 914 novice runners were categorized into 1 of 3 exposure groups, based on their body mass index (BMI): (1) normal weight (BMI less than 25 kg/m2, n = 405; reference group), (2) overweight (BMI of 25 to less than 30 kg/m2, n = 341), and (3) obese (BMI of 30 kg/m2 or greater, n = 168). All runners were equipped with a global-positioning-system running watch, which provided information about distance, duration, speed, and date of each running session during the first week of a self-chosen running regime.

Results

During the first session, overweight runners (difference, −0.5 km/h; 95% confidence interval [CI]: −0.8, −0.2 km/h; P<.05) and obese runners (−1.7 km/h; 95% CI: −2.0, −1.4 km/h; P<.05) ran slower than normal-weight runners. Obese runners also ran a shorter distance compared to normal-weight runners (−0.4 km; 95% CI: −0.7, −0.2 km; P<.05). During the first week, overweight runners (−0.5 km/h; 95% CI: −0.7, −0.2 km/h; P<.05) and obese runners (−1.7 km/h; 95% CI: −2.0, −1.4 km/h; P<.05) ran slower than normal-weight runners, while running distance and duration were similar.

Conclusion

Overweight and obese runners selected a similar training dose to that of normal-weight runners when starting a self-chosen running regime. This may partly explain the higher running-injury risk among overweight and obese runners compared with normal-weight runners observed by other studies. J Orthop Sports Phys Ther 2018;48(11):873–877. Epub 22 Jun 2018. doi:10.2519/jospt.2018.8169
DÜNYA’DA VE TÜRKİYE’DE HİZMET TİCARETİNİN GELİŞİMİ
Authors: KIRATLI Fatih
Published: June 2018

Bu çalışmanın amacı, dünya ticaretinin serbestleşmesiyle birlikte dünya
hizmet ticaretindeki gelişmeler ve Türkiye’nin hizmet ticareti
değerlendirilmektedir. Dünya ülkelerinin ve Türkiye’nin hizmet ticareti gelişim
seyri incelendiği bu çalışmada, Dünya Ticaret Örgütü, Türkiye İstatistik Kurumu
ve Türkiye Cumhuriyeti Merkez Bankasının 1985-2017 yılları arası hizmet sektörü
ihracat ve ithalat verileri kullanılmıştır. Sonuç olarak Türkiye hizmet
ticaretinde bilgi, teknoloji, beşerî sermayesi ve donanımı bakımından birçok
üstünlüklere sahiptir. Türkiye’nin özellikle turizm ve taşımacılık sektörlerinde yüksek kapasiteye ve etkinliğe sahip
olduğu görülmüştür. Türkiye’de 2017 yılı verilerine göre turizm sektörü, hizmet
ticareti gelirlerinin yaklaşık %51’ini karşılamıştır. Türkiye’nin geleneksel hizmetler kapsamında etkin olduğu diğer bir
hizmet sektörü ulaştırma hizmetleridir. Türkiye’ye 2017 yılı için turizm
sektöründen sonra yaklaşık %35’lik payla hizmet ticareti açısından en fazla
döviz geliri sağlayan ikinci sektör taşımacılık sektörüdür. Genel olarak bakıldığında Türkiye’nin dış
ticaret açığı ve cari açıklarının
dengelenmesinde özellikle turizm, taşımacılık ve inşaat gibi hizmet sektörlerinden elde edilen
döviz gelirleri ile finanse etmeye çalışmıştır. Türkiye’nin uluslararası hizmet
ticaretindeki payının daha da artırılabilmesi için, geleneksel rekabet gücünün
olduğu sektörlere, potansiyeli
olan yeni alt sektörler eklenmeli ve çalışmalar bu alanlarda daha fazla yoğunlaştırılmalıdır.
Discovering a Transferable Charge Assignment Model Using Machine Learning
Authors: Sifain Andrew E. , Lubbers Nicholas , Nebgen Benjamin T. , Smith Justin S. , Lokhov Andrey Y. , Isayev Olexandr , Roitberg Adrian E. , Barros Kipton , Tretiak Sergei
Published: June 2018

Partial atomic charge assignment is of immense practical value to force field parametrization, molecular docking, and cheminformatics. Machine learning has emerged as a powerful tool for modeling chemistry at unprecedented computational speeds given ground-truth values, but for the task of charge assignment, the choice of ground-truth may not be obvious. In this letter, we use machine learning to discover a charge model by training a neural network to molecular dipole moments using a large, diverse set of CHNO molecular conformations. The new model, called Affordable Charge Assignment (ACA), is computationally inexpensive and predicts dipoles of out-of-sample molecules accurately. Furthermore, dipole-inferred ACA charges are transferable to dipole and even quadrupole moments of much larger molecules than those used for training. We apply ACA to long dynamical trajectories of biomolecules and successfully produce their infrared spectra. Additionally, we compare ACA with existing charge models and find that ACA assigns similar charges to Charge Model 5, but with a greatly reduced computational cost.
Somatic role of SYCE2: an insulator that dissociates HP1α from H3K9me3 and potentiates DNA repair
Authors: Hosoya Noriko , Ono Masato , Miyagawa Kiyoshi
Published: June 2018

The synaptonemal complex is a proteinaceous structure essential for meiotic recombination, and its components have been assumed to play a role exclusively in the germ line. However, SYCE2, a component constituting the synaptonemal complex, is expressed at varying levels in somatic cells. Considering its potent protein-binding activities, it may be possible that SYCE2 plays a somatic role by affecting nuclear functions. Here, we show that SYCE2 constitutively insulates HP1α from trimethylated histone H3 lysine 9 (H3K9me3) to promote DNA double-strand break repair. Unlike other HP1α-binding proteins, which use the canonical PXVXL motifs for their bindings, SYCE2 interacts with the chromoshadow domain of HP1α through its N-terminal hydrophobic sequence. SYCE2 reduces HP1α-H3K9me3 binding without affecting H3K9me3 levels and potentiates ataxia telangiectasia mutated–mediated double-strand break repair activity even in the absence of exogenous DNA damage. Such a somatic role of SYCE2 is ubiquitously observed even if its expression levels are low. These findings suggest that SYCE2 plays a somatic role in the link between the nuclear microenvironment and the DNA damage response potentials as a scaffold of HP1α localization.
AN ANALYSIS OF TEACHERS’ QUESTIONING STRATEGIES IN ELT (ENGLISH LANGUAGE TEACHING) THE CLASSROOM INTERACTION AT ELEVENTH GRADE SMA MUHAMMADIYAH 1 UNISMUH MAKASSAR
Authors: Erianti Ayu , Akib Erwin , Baso Farisha Andi
Published: June 2018

This research deals with teacher questions in senior high school English classroom. The study was conducted to answers three of problem statement. The study was conducted at SMA Muhammadiyah 1 UNISMUH Makassar with the descriptive qualitative method. The study was carried out by observing, interview and taking video recordings of 1 English teacher and 15 students. The researcher takes 2 class in one meeting consist of 90 minutes each class. The result showed that procedural (13%), display (74%) and referential (13%) questions were found in the type of teacher questioning strategies used. However, the reason why teacher used the types of the question is according to the function of the question type. Then the effect of the question to the students based on 6 questions that researcher asked. 60% students agree with the Q1 and 40% disagree. For the Q2 100% students agree with the question that researcher ask and also the Q3 100% students agree with the question. While for Q4 60% students agree and 40% of them disagree. 40% agree and 60% disagree to Q5 and 80% agree and 20% disagree for the Q6.
From students and lecturer’s perspectives of new on-line Web-based simulation tools as Power Electronics Facilities. Launching surveys for assessment stage
Authors: Trujillo-Aguilera F. David , Sotorrío-Ruiz Pedro , Pozo-Ruz Ana , Blázquez-Parra Elidia Beatriz , Trujillo-Vanegas Catalina
Published: June 2018

Information and Communication Technology is progressively including greater spaces in human beings’ life. A web tool has been developed for Power Electronics subject. This developed educational software is necessary as an important resource in the students' teaching/learning process. An evaluation process is used to evaluate the quality of this tool. The results demonstrate that the use of this web tool improves the students' motivation.
Cellular Warehousing for Omnichannel Retailing: Internet of Things and Physical Internet Perspectives
Authors: Wang Xin , Kong Xiang T.R. , Huang George Q. , Luo Hao
Published: June 2018

Significant expansions have been reflected worldwide in business reports of major E-commerce players such as Alibaba, Amazon and JD.com. Omnichannel retailing is an evolutional variant of E-commerce by providing consistent, unique and contextual brand experiences across multiple customer-aware touchpoints. Despite all the efforts, goods still move slowly and damages are a concern along with the booming omnichannel retailing. Meanwhile, high variety and variability of omnichannel retailing orders complicate the implementation of automated facilities. To deal with these phenomenal and challenging problems, a new warehousing paradigm named cellular warehousing is proposed. The concept of cellular warehousing is adapted from cellular manufacturing, taking full advantage of the similarities between online-offline orders and/or their items as well as standardization and common processing. To sum up, the paper will firstly introduce the key processes within the IoT/PI-based cellular warehouse, and then cover the major elements to support the operation. Finally, three representative case studies of Alibaba, JD.com and COSCO will be presented to verify the necessity to transform the existing warehouses to cellular warehouses.
Anlatının Söylemi: Yöntem Hakkında Bir Deneme
Authors: PARIN Kamil
Published: June 2018

Gérard Genette tarafından
kaleme alınan Anlatının Söylemi, 2011
yılında Ferit Burak Aydar tarafından çevirisi yapılır ve Boğaziçi Üniversitesi
Yayınevi tarafından basılır. Eser; Ön söz ve Giriş kısmından sonra Düzen, Süre,
Sıklık, Kip ve Ses olmak üzere beş bölümden oluşur. Son söz, Kaynakça ve Dizin
ile sona erer. Eserin alt başlıkları şu şekildedir: 1. Düzen; Anlatı Zamanı? Anakroniler,
Erim-Kapsam, Analepsisler, Prolepsisler, Anakroniye Doğru. 2. Süre;
Anisokroniler, Özet, Ara, Eksilti, Sahne. 3. Sıklık; Tekilci/Yinelemeli,
Belirlenim-Saptama-Kaplam, İçsel ve Dışsal Artzamanlılık, Münavebe-Geçişler,
Zamanla Oynanan Oyun. 4. Kip; Anlatı Kipleri, Mesafe, Olay Anlatıları, Sözcük
Anlatıları, Perspektif, Odaklanmalar, Değiştirmeler, Çok-Kiplilik. 5. Ses;
Anlatılama Edimi, Anlatılama Zamanı, Anlatı Düzeyleri, Üst Öyküsel Anlatı,
Metalepsis, Jean Santeuil’den Kayıp Zaman’a: Sözde Öyküselin Zafer, Şahıs,
Kahraman/Anlatıcı, Anlatıcının İşlevleri, Anlatılan.Eserin beş bölümden oluştuğunu ifade etmiştik. Şimdi
bölümlerde neleri ele almış bunlara değineceğiz. Birinci bölüm, olayların nasıl
sıralandığıyla ilgili düzen bölümüdür. Genette anlatıdaki olayların kronolojik
olmayan düzenini “anakroni” (hikâye ile anlatının iki düzenlenişi arasındaki
farklı uyumsuzluktur) terimiyle ifade eder. Genette “öngörü” ve “geriye dönüş”
terimlerini kullanmak yerine anakroniyi ikiye ayırır: Analepsis ve Prolepsis.
Analepsis: Anlatıcı önceden olmuş bir olayı ya da olayları anlatır. Prolepsis: Sonra
yer alacak bir olayı şimdiden anlatılamak ya da çağrıştırmaktan ibaret olan
anlatı manevrası. Genette, eksilti ya da geri dönüşsüz ileri atlamayı anakroni olarak
kabul etmez, yalnızca anlatının hızlandırılmasıdır der. Ayrıca halk anlatısının,
en azından en önemli eklemlenişlerinde kronolojik sıraya alışkanlıkla uyum
gösterdiğini, oysa Batılı edebi geleneğin tam tersine anakroninin tipik bir
etkisiyle başladığını düşünür. Anakronileri, geriye dönüş ve öngörü üzerinden
analepsis ve prolepsis olarak adlandırdıktan sonra herhangi bir benzerlik
(mekânsal, zamansal ya da başka türlü) tarafından yönetilen anakronik öbeklere
de silepsis (beraber olma olgusu) adını verir.
APTITUD TERRITORIAL PARA ESTABLECER SISTEMAS DE CAPTACIÓN DEL AGUA DE LLUVIA PARA COMBATIR INCENDIOS FORESTALES
Authors: León Villalobos José María , Anaya Garduño Manuel , Oropeza Mota José Luis , Ojeda Trejo Enrique , Rodríguez Trejo Dante Arturo , García Rodríguez Jorge Luis
Published: June 2018

El control de incendios forestales con helicópteros es una práctica común en el Estado de México que está limitada por la disponibilidad de fuentes de agua para la recarga de las aeronaves. Los sistemas de captación del agua de lluvia (SCALL) se pueden usar para su abastecimiento. La identificación de sitios con aptitud para SCALL en zonas de alta incidencia de incendios es fundamental para mejorar la eficiencia del control aéreo; sin embargo, la selección de los lugares requiere integrar numerosas variables. En el presente estudio se efectuó un análisis de evaluación multicriterio mediante Sistemas de Información Geográfica (SIG) para identificar los sitios con aptitud para SCALL en el área de interés, para lo cual se eligieron cinco variables: velocidad de ráfaga de viento, distancia a los caminos, escurrimiento superficial, evaporación y densidad de incendios. Las variables fueron ponderadas con el apoyo del coordinador de vuelo de las aeronaves y se integraron en un mapa de aptitud por el método de combinación lineal ponderada en Arc Gis 9.2 y Arc View 3.2. Se detectaron de forma rápida y flexible dos sitios con aptitud para establecer SCALL en el área de estudio: uno al norte y otro al sur; y el mapa que los muestra se elaboró a una escala de 1 a 10.
SISTEMA DE CUBICACIÓN PARA ÁRBOLES INDIVIDUALES DE Tectona grandis L. f. MEDIANTE FUNCIONES COMPATIBLES DE AHUSAMIENTO-VOLUMEN
Authors: Tamarit Urías Juan Carlos , De los Santos Posadas Héctor M. , Aldrete Arnulfo , Valdez Lazalde J. René , Ramírez Maldonado Hugo , Guerra De la Cruz Vidal
Published: June 2018

Se construyó un sistema de cubicación de árbol individual generado a partir de una función segmentada de ahusamiento para plantaciones de Tectona grandis establecidas en Campeche, Tabasco y Chiapas. Se cubicaron 144 árboles de diferentes edades; para cada uno se midió el diámetro con corteza y la altura sobre el fuste a 1 m después del tocón hasta la altura total. Se evaluó el ajuste estadístico de seis funciones segmentadas de ahusamiento y se seleccionó al modelo de Fang como el mejor por presentar la mayor precisión, el menor sesgo y por describir el ahusamiento del fuste correctamente. De forma simultánea se le hizo un ajuste con su respectiva función de volumen comercial basado en la técnica de modelo de efectos mixtos, con lo que se logró controlar la variación específica a nivel de árbol, mejorar la estimación de los parámetros y la precisión de las predicciones. Los resultados indican que el sistema de cubicación derivado se conforma de ecuaciones que describen con exactitud el perfil fustal y estiman el volumen comercial y total, así como la altura comercial a un diámetro mínimo y viceversa. Los puntos de cambio en la forma dendrométrica del fuste son similares a los de otras especies de árboles latifoliados. El equivalente al factor de forma que procede del modelo de volumen total fue de 0.43 en promedio y permite realizar estimaciones muy cercanas a los volúmenes observados; comparativamente es inferior al calculado para esta especie en otras regiones tropicales.
REGENERACIÓN NATURAL DEL MATORRAL ESPINOSO TAMAULIPECO EN UNA PLANTACIÓN DE Eucalyptus spp.
Authors: Martínez Hernández Dinorah Dalila , Jiménez Pérez Javier , Alanís Rodríguez Eduardo , Uvalle Sauceda José Isidro , Canizales Velázquez Pamela Anabel , Rocha Domínguez Luis
Published: June 2018

Las plantaciones forestales con especies exóticas generan controversia a nivel mundial y tal es el caso de la presencia de eucaliptos en México. En el presente estudio se caracterizó la regeneración natural de vegetación leñosa en el Matorral Espinoso Tamaulipeco (MET), que se localiza en el noreste del país, dentro de una plantación original de Eucalyptus spp. La investigación se llevó a cabo 27 años después de su establecimiento y en ella se instalaron 1 sitios de muestreo de 250 m2 (10 x 25 m) para evaluar todos los ejemplares con crecimiento secundario que presentaran un diámetro basal (d0.50) mayor o igual a 0.5 cm. Los datos recabados permitieron estimar índices de riqueza y diversidad, así como abundancia relativa, dominancia y frecuencia; con estos números se calculó el Índice de Valor de Importancia. Se demostró que en la zona existe renovación de las especies de interés en la siembra original y los parámetros poblacionales propios son similares a las de otras áreas con características parecidas; además se presentó sucesión ecológica, después de haber sido sujetas a actividades agrícolas, pecuarias y forestales (matarrasa). Se registró alta densidad (4 301 ind ha-1) y mayor cantidad de individuos de clases diamétricas bajas (<2 cm).
Addressing the Challenges and Issues of Blood Donation via Ubiquitous Computing
Authors: Sugijarto Dian Pradhana , Safie Nurhizam , Mukhtar Muriati , Sulaiman Riza
Published: June 2018

Blood is undeniably essential to save lives. The high demand for blood cannot compete with the amount collected through blood donation. In order to cater to the issue, researchers tend to focus more on the donorsâ€™ side. Meanwhile, the other party which is the blood bank continues to play its role to increase the blood supply. The blood bank processes blood in four stages: donation, screening, inventory and hospital pickup. This paper aims to address the challenges and issues in the local blood bank through ubiquitous computing, specifically at the blood donation stage. Blood donation is the most critical stage where the blood bank engages directly with the donors. The issues and challenges faced by the blood bank are uncovered by, interviews, field study and literature reviews. The proposed solution takes advantage of the ubiquitous computing concept that enables devices to communicate with each other seamlessly. With the advancement of mobile technology, smartphones become the closest of any devices to achieve ubiquitous computing. Communication technologies like Near Field Communication and Wi-Fi aid the interaction between the user and the system which are expected to solve the challenges and issues of blood donation.
Development of TTS Engine for Indian Accent using Modified HMM Algorithm
Authors: Gantayat Sasanko Sekhar
Published: June 2018

A text-to-speech (TTS) system converts normal language text into speech. An intelligent text-to-speech program allows people with visual impairments or reading disabilities, to listen to written works on a home computer. Many computer operating systems and day to day software applications like Adobe Reader have included text-to-speech systems. This paper is presented to show that how HMM can be used as a tool to convert text to speech.
Optimization of Digital Image Processing Method to Improve Smoke Opacity Meter Accuracy
Authors: Putra Dwi Sudarno , Fernandez Donny , Wagino -
Published: June 2018

One of the parameters of exhaust emission testing on diesel engines is the level of smoke opacity. If the opacity is high then the emission quality is bad. The instrument for measuring smoke opacity is called Smoke Opacity Meter. The commonly used basic concept to measure smoke density is by utilizing a light sensor (optical sensor). Development of Smoke Opacity Meter applies the concept of Digital Image Processing. Even though it has initially begun, the measurement result is yet as perfect as Optical Sensor Concept. Therefore, this paper describes on how to implement the Digital Image Processing Method in processing the smoke opacity video data.
Improving Sports Participation among Students through Mobile Application
Authors: Ching Heng Zhuang , Wahid Norfaradilla , Hafit Hanayanti , Kasim Shahreen
Published: June 2018

Technologies are advancing at incredible speed with great purposes. Unfortunately, as technologies grow, some people have lost their motivation to keep up with their health by neglecting their physical activities like sports, outdoor games, etc. There are less people willing to step outside to do physical activities especially those which requires companions or members. We cannot deny the fact that there are still people who are willing to come out and do sports in a group. However, most of the time they do not have enough members to conduct the sport. This situation can lead to discouragement and stopping them from doing any more sports activity just because of insufficient team member. This situation can lead to discouragement and stopping them from doing any more sports activity just because of insufficient team members. The Sports Team Finder is a mobile application that helps the students in Universiti Tun Hussein Onn Malaysia (UTHM) to reach other people who has the same intention, i.e., to get team members. Students can use this application to find team members for team-oriented games such as basketball, football, netball, etc. The aim is to design an application where it motivate users to engage other people through sports and meeting new friends along the way. The application is able to function properly and successfully gather users with similar interest together. It has shown that the application has caused an improvement of sport involvement among students in UTHM.
Bitcoin Generation using Blockchain Technology
Authors: Maram Balajee
Published: June 2018

There are limitations in client-server model of communication. Distributed architecture provides good accessibility to all the nodes in the network. A blockchain technology is follows distributed model. In the digital era, all the transactions are available in the digital form is called a ledger. This ledger belongs to all the users in the network are shared by all the users in the network. Every transaction is monitored and verified by every user in the network. The blockchain is a chain of blocks that contains a collection of transactions. Bitcoin is a cryptocurrency, depends on blockchain technology. The Bitcoins are generated from the mining of a block for the miner. Every user knows about each and every Bitcoin transaction in the blockchain network. The block is immutable, because every block is verified by each customer in the blockchain network. This is the initiation for new trend for security to the digital transactions in the world. This paper presents the logic in the blockchain and Bitcoin generation process using blockchain technology.
An Analytical Approach for Decision-Making
Authors: Aggarwal Sakshi , Sagar Shrddha
Published: June 2018

In this complex world, coping with daily problems is quite tedious. The more advancement in technology means more difficulties in decision-making process. Hence some analytical tools are needed to deal with improvement in decisions being made. A classic AHP model enables us to make efficient decision by reducing the complex issues. It takes multiple parameters into consideration. One of the area where decision-making is quite a tough job is Politics. Selection of the electoral party in any elections, be it Lok Sabha elections or Rajya Sabha elections, has been a matter of discussion for the voters as well as the media. The decisions are reflected when uncertainties are added in the opinions of the domain experts due to multiple parameters.Â  In this paper we have proposed a model for rectifying the uncertainties using multi criteria decision analysis and analytic hierarchy process (AHP).
Weighting based approach for learning resources recommendations
Authors: Bourkoukou Outmane , Achbarou Omar
Published: June 2018

Personalized e-learning systems based on recommender systems refines enormous amount of data and provides suggestions on learning resources which is appealing to the learner. Although, the recommender systems depends on content based approach or collaborative filtering technique to make recommendations, these methods suffers from cold start and data sparsity problems. To overcome the limitations of the aforementioned problems, a weight based approach is proposed for better performance. The main criterion for building a personalized recommender system is to exploit useful content and provide better recommendations with minimal processing time. The proposed system is a web based client side application which uses user profiles to form neighborhoods and calculates predictions using weights. For newcomers a profile is constructed based on learning styles. The resources which might be of interest to the user are predicted from calculated predictions.