bluuebunny/crossref_metadata_2025 huggingface dataset:
Adrenomedullin mediates lung metastasis of colorectal cancer through CRLR receptor
Authors: Fang Yanfei , Xu Xutao , Lian Qingwu , Yao Lingya , Lin Zhenghua , Wang Lan , Chen Shujie , Xue Meng
Published: March 2023

Purpose: The current study investigated adrenomedullin (ADM) as a potential autocrine regulator of colorectal cancer (CRC) cells.
Methods: The expression levels of ADM and calcitonin receptor–like receptor (CRLR) mRNA in 26 primary colorectal tumor and adjacent non-tumor tissues were analyzed by quantitative real time (qRT)-PCR. And CRLR expression in 7 CRC cell lines was tested by qRT-PCR and Western blot analysis. Cell migration, invasion and lung metastasis were detected in vitro and in vivo after exogenous ADM stimulation and silencing of CRLR.
Results: We found that the expression levels of ADM and CRLR were significantly higher in colon cancers than those in adjacent nontumorous tissues. In addition, the expression levels of ADM and CRLR in CRC were correlated with UICC stage, 7lymph node metastasis and differentiated degree. Exogenous ADM promoted the migration of RKO and HT-29 cells, and RNA silencing of CRLR in colon cancer cells blocked ADM-induced migration and invasion, suggesting that CRLR might be involved in the autocrine actions of ADM. Xenograft tumors with CRLR knockdown had dramatically reduced lung metastasis compared to control cells.
Conclusions: This study describes the important roles of ADM in potentiating the aggressive characteristics of CRC, and the CRLR receptor was identified as being critical for these effects. These observations provide significant insights into the multifaceted role of ADM in CRC. Combined with the known importance of ADM as an angiogenic factor, these data generally support the further development of CRLR as a potential therapeutic target of CRC.
Comparison of accuracy of different lymph node ratio grouping systems in predicting prognosis of Stage IV colon cancer
Authors: E Yimin , Sun Sizheng , Huang Yicheng , Lu Chen , Fan XiaoYu , Chu Chaoshun , Yu Chunzhao
Published: March 2023

Objective
With the improvement of surgical treatment, many studies have questioned the accuracy of the AJCC staging system in that it ignores examined lymph nodes (ELNs). Lymph node ratio (LNR) is supposed to make up for this deficiency. The aim of this study is to compare the prognostic performance of different LNR grouping systems relative to the American Joint Committee on Cancer (AJCC) 8th N staging system in stage IV colon cancer.
Methods
Approximately 8672 patients undergoing primary surgical resection of stage IV colon cancer were extracted from the Surveillance, Epidemiology, and End Results (SEER) program database. The Harrell’s concordance index (C-index) and Akaike's Information Criterion (AIC) were used to distinguish the prognostic performance of different LNR and AJCC 8th N staging systems.
Results
Among 8672 colon cancer patients with distant metastasis, 7322 (84.43%) had lymph node involvement, and the median of ELNs was 17. The Group2 staging system of LNR (cutoff points: 1/14; 0.25; 0.50) was superior to the 8th AJCC-N staging system and other LNR grouping systems, with the most considerable discrimination power (C-index, 0.711; AIC, 121419.1), and showed an advantage in any of the ELNs. When models were used as categorical cutoff variables for further clinical application, The second LNR grouping system outperformed the other three schemes with either ELNs less than 12 (C-index, 0.723; AIC, 16735.24), between 12 and 25 (C-index, 0.707; AIC, 76007.79), or more than 25(C-index, 0.701; AIC, 15613.2) with increasing C-index and less AIC value.
Conclusion
When evaluating different LNR grouping systems and the 8th AJCC-N staging system, regardless of ELNs, the second LNR grouping system (the cut-off value of LNR was 1/14; 0.25; 0.50) showed the best discrimination and goodness of fit in predicting survival in stage IV colon cancer patients.
Analysis of quality changes and hot air drying characteristics of Xinjiang jujube (Zizyphus jujuba cv. Junzao) by hang on trees drying
Authors: Xu Chao , Yi Xiaokang , Hu Can , Yang Qiaonan , Li Jie , Yang Yi , Zhang Jie
Published: March 2023

The purpose of this study was to explore the changes in quality indicators and hot air drying characteristics of jujube during the natural hang on trees drying stage, and to determine the optimal picking period for Xinjiang jujube suitable to drying and processing, samples were collected six times in a 7-day cycle, respectively denoted as S1-S6, research the effects of different picking stages on the nutrient content, color, hot air drying kinetics and drying quality of Xinjiang jujube during hang on trees drying. The results showed that the water content of jujube gradually decreased; the percentage of soluble solids, total and reducing sugars increased, but the total mass of those in a single jujube decreased, and the percentage of ascorbic acid and total mass decreased during the natural drying process. The hot air drying time is different at different picking stages. The highest ascorbic acid content after hot air drying is 87.14 mg/100 g for jujube at stage S4. with a decreasing trend in cracking rate after drying from S1 to S6 and an increasing trend in rehydration. Used AHP to evaluate the quality comprehensively, found that jujube picked at S4 were more suitable for drying and processing.
IL-6 and IL-17 may provide a potential link between hypertension and long-COVID sequelae in hemodialysis patients: A multicenter cross-sectional study
Authors: Stepanova Natalia , Driianska Victoria , Rysyev Andriy , Ostapenko Tetyana , Kalinina Nataliia
Published: March 2023

Objective
The mechanisms underlying long COVID in patients treated with hemodialysis (HD) are not yet fully understood. We hypothesized that uncontrolled blood pressure (BP) before infection might contribute to the development of long-COVID symptoms in HD patients through upregulation of interleukin (IL)-6 and IL-17 production, possibly associated with severe acute COVID-19. In the present cross-sectional study, we examined serum IL-6 and IL-17 levels at two time points after acute COVID-19 infection taking into account preinfection BP and the presence of long-COVID sequelae in HD patients.
Results
A total of 80 HD patients aged 56 (44–63.2) years with a dialysis vintage of 4.7 (3.3 − 7.08) years who had experienced COVID-19 at least 5 months before enrollment were included in this cross-sectional study. We found that preinfection uncontrolled BP was associated with long-COVID sequelae in HD patients. Both hypertension and long COVID resulted in elevated IL-6 and IL-17 concentrations, peaking in patients with both conditions and decreasing over time after COVID-19 possibly reflecting Th17-related systemic inflammation during the acute phase of COVID-19.
Performance Enhancement of Surface Plasmon Resonance Sensor Based on 2D Nanomaterial
Authors: Ouardi Mohamed Esseddik , Tayeboun Fatima , Meradi Kada A.
Published: March 2023

Two-dimensional materials are becoming increasingly popular among researchers, commonly used in surface plasmon resonance (SPR) sensors. The usage of a different glass for the prism (BK7) and adding a thin film of Silicon dioxide (SiO2) allowed to enhance the sensitivity of the SPR sensor, the performances of the latter were measured using sensitivity, figure of merit (FOM) and the detection accuracy. The structure was improved by changing some materials along with the structural parameters in order to gain in performance. The results showed that using BK7 glass and adding a transition metal dichalcogenide ‘Platinum diselenide’ (PtSe2) with a thin layer of Silicon dioxide (SiO2) and Boron phosphide (BP) over a gold (Au) layer of the conventional structure improved the performances of our sensor. The maximum sensitivity measured is 240°/RIU with a figure of merit of 26.90RIU− 1. The high sensitivity proposed sensor can be applied for biosensing in order to detect biological samples.
Prophylactic drainage versus non-drainage following gastric cancer surgery: a meta-analysis of randomized controlled trials and observational studies
Authors: Pang Hua-Yang , Chen Li-Hui , Chen Xiu-Feng , Yan Meng-Hua , Chen Zhi-Xiong , Sun Hao
Published: March 2023

Background
The role of prophylactic drainage (PD) in gastrectomy for gastric cancer (GC) is not well-established. The purpose of this study is to compare the perioperative outcomes between the PD and non-drainage (ND) in GC patients undergoing gastrectomy.
Methods
A systematic review of electronic databases including PubMed, Embase, Web of Science, the Cochrane Library and China National Knowledge Infrastructure was performed up to December 2022. All eligible randomized controlled trials (RCTs) and observational studies were included and meta-analyzed separately. The registration number of this protocol is PROSPERO CRD42022371102.
Results
Overall, 7 RCTs (783 patients) and 14 observational studies (4359 patients) were ultimately included. Data from RCTs indicated that patients in the ND group had a lower total complications rate (OR = 0.68; 95%CI:0.47–0.98; P = 0.04; I2 = 0%), earlier time to soft diet (MD=-0.27; 95%CI: -0.55 to 0.00; P = 0.05; I2 = 0%) and shorter length of hospital stay (MD=-0.98; 95%CI: -1.71 to -0.26; P = 0.007; I2 = 40%). While other outcomes including anastomotic leakage, duodenal stump leakage, pancreatic leakage, intra-abdominal abscess, surgical-site infection, pulmonary infection, need for additional drainage, reoperation rate, readmission rate and mortality were not significantly different between the two groups. Meta-analyses on observational studies showed good agreement with the pooled results from RCTs, with higher statistical power.
Conclusion
The present meta-analysis suggests that routine use of PD may not be necessary and even harmful in GC patients following gastrectomy. However, well-designed RCTs with risk-stratified randomization are still needed to validate the results of our study.
Clinical prognosis and related molecular features of hepatitis B associated adolescent and young adult hepatocellular carcinoma
Authors: Lv Tao , Zhang Bo , Xu Xi , Jiang Chenhao , Zheng Daofeng , He Diao , Zhou Yongjie , Yang Jiayin
Published: March 2023

Background Little attention has been paid on the pathogenesis of adolescent and young adult (AYA) hepatocellular carcinoma (HCC), while due to the more advanced tumor progression and poorer prognosis of AYA-HCC, together with their better tolerance ability, non-cirrhotic background and stronger willingness to treatment, therefore, related clinical and molecular biology researches are urgent and necessary, especially for those with Hepatitis B infection. Methods For clinical aspect, the overall survival, recurrence-free survival and COX analysis were performed. Then, function analysis, gene clustering, metabolic-related analysis, immune infiltration and competing endogenous RNAs (ceRNAs) construction were carried out using whole transcriptome sequencing technique. Results Based on the clinical information of our HCC cohort, the overall survival and recurrence-free survival rates were worse in the young group than in the older group as previously described. According to our whole transcriptome sequencing results, functional analysis revealed that metabolism-related pathways as well as protein translation and endoplasmic reticulum processing were enriched. Then the hub metabolism-related genes were screened by metabolite-protein interactions (MPIs) and protein-protein interactions (PPIs). Among the metabolic pathways, fatty acid metabolism is of great significance, abnormalities in which may be the reason for worse prognosis of HBV-AYA HCC. Finally, the relationship of disrupted expression of metabolism-related genes with immune infiltration was also analyzed, and the lncRNA-miRNA-mRNA related ceRNA network for HBV-AYA HCC were constructed, which may provide new cues for HBV-AHA HCC prevention. Conclusions The worse prognosis and recurrence rate of HBV-AYA HCC may be related to abnormalities in metabolism-related pathways, especially disorder of fatty acid metabolism.
Effect of exhaust gas recirculation on emission, combustion and performance of DI-CI engine fueled with alcohol/diesel blends
Authors: Mishra Ved Prakash , Barman Shambhunath , Mondal Pradip
Published: March 2023

Nowadays, in spite of stringent emission norms, air quality index and fossil resource have been degrading, due to increasing demand of fossil fuel, to meet the direct-indirect requirement of fast-growing population. 2nd generation feedstocks (agricultural residual) based alcohols could add renewability to petroleum-based diesel and reduce diesel engine emissions. This research work sets out to investigate the effect of EGR on combustion, performance and emission characteristics of a VCR diesel engine fuelled with ethanol and butanol blended 12% volumetrically in diesel. The test fuel containing 12%v/v of ethanol and butanol (designated as E12D88 and B12D88) in diesel were experimented at 6 different loads (2, 4, 6, 8, 10 and 12Kg) and compared with D100. Brake thermal efficiency (BTE) and brake specific fuel consumption (BSFC) of B12D88 fuel was similar to that of pure diesel (D100), better than E12D88. NOx emission for B12D88 was higher than E12D88, lower than D100 and increased with increase in load for all tested fuel. HC and CO emission for E12D88 was higher than D100 and B12D88. Combustion duration (CD), maximum in-cylinder pressure (CPmax), maximum neat heat released (NHRmax) and maximum mean gas temperature (MGTmax) for the tested fuels were in the sequence: D100 > B12D88 > E12D88, D100 > B12D88 > E12D88, E12D88 > D100 > B12D88 and E12D88 > D100 > B12D88, respectively. Exhaust gas recirculation (EGR) with 5% and 10% opening were used with B12D88 (designated as B12D88EGR5 and B12D88EGR10). With increase in EGR percentage from 5–10% BTE and BSFC of the B12D88 fuel was improved at higher loading, NOx emission was reduced and was better than E12D88, CO and HC emission increased considerably. With increase in EGR percentage there is drop in CPmax, MGT, ignition delay, NHRmax and increase in CD.
Differences in the secondary metabolites of different varieties of black tea and evaluation of their disease-resistance activity
Authors: Liu Zhongying , Zhang Tuo , Ran Qiansong , Fang Shimao , Pan Ke , Long Lin
Published: March 2023

Rich secondary metabolites render black tea its unique flavor and health benefits, making it the most widely consumed tea in the world. Yet, few studies have investigated the differences in secondary metabolites between black-tea varieties and whether secondary metabolites have antidisease activity. Using gas chromatography-tandem mass spectrometry metabolomics and the Traditional Chinese Herbal Medicine Systems Pharmacology Platform database, this study investigated differences in the secondary metabolites of varieties of black tea, including Fuding Dabai (FD), Golden Guanyin (JGY), Golden Peony (JMD), Qianmei 601 (Q601), and Qiancha 1 (Q). Then, the antidisease activity of their secondary metabolites was evaluated. A total of 657 secondary metabolites were identified in the different black-tea varieties. Among them, 183 metabolites had antidisease activity, 113 were key active ingredients in traditional Chinese medicine (TCM), 73.22% had multiple antidisease activities, and all were mainly flavonoids and phenolic acids. The specific differential metabolites of FD vs JGY, FD vs JMD, FD vs Q, and FD vs Q601 and their disease-resistance activities were (67, 17), (24, 5), (26, 6), and (65, 8), respectively. The main enriched metabolic pathways were phenylpropanoid biosynthesis, biosynthesis of secondary metabolites, flavonoid biosynthesis, and metabolic pathways, with four, four, six, and five key metabolites, respectively. Flavonoid and phenolic acid secondary metabolites were more correlated with antidisease activity and key active TCM ingredients.
Conclusion: The types of secondary metabolites were consistent among the different black-tea varieties, while the relative contents differed significantly, with greater differences in secondary metabolites between JGY and Q601. Flavonoid and phenolic acid secondary metabolites were the main contributors to the differences in secondary metabolites and the disease-resistance activity of different black-tea varieties, followed by lignans with coumarins, alkaloids, and tannins also contributing to disease-resistance activity. These findings improve our understanding of the secondary metabolites and health benefits of different varieties of black tea.
Insulin and toll-like receptor 4 interaction in the rat model of Parkinson’s disease induced by lipopolysaccharide
Authors: Hemmati Fatemeh , Valian Neda , Ahmadiani Abolhassan , Mohamed Zahurin , Ali Raymond Azman , Ibrahim Norlinah Mohamed , Shirazi Seyed Farshad Hosseini
Published: March 2023

Toll-like receptor (TLR) 4 is involved in neuroinflammatory processes – both in peripheral tissues and the central nervous system. Pro-inflammatory cytokines production due to over activation of TLR4 interfere with insulin signaling elements and induce insulin resistance. Regarding the critical roles of TLR4 and insulin signaling in the pathogenesis of Parkinson’s disease (PD), in the present study the TLR4/insulin receptor interaction was assessed in a neuroinflammation model of PD. LPS was injected in the right striatum of male Wistar rats (20µg/rat). Insulin (2.5IU/day), insulin receptor antagonist (S961; 6.5nM/kg) or TLR4 antibody (Resatorvid (TAK242); 0.01µg/rat) were administered intracerebroventricular (ICV) for 14 days. Insulin and TAK242 were also simultaneously injected in a distinct group. Behavioral assessment was performed using rotarod, apomorphine-induced rotation and cylinder tests. The levels of α-synuclein, TLR4 and insulin signaling were measured in the striatum. LPS impaired motor performance of the animals, and increased the levels of α-synuclein and TLR4. Furthermore, it reduced mRNA levels of IRS1 and IRS2 and enhanced GSK3β mRNA and protein, indicating the development of insulin resistance. Treatment with insulin, TAK 242, and combination therapy were able to restore insulin signaling and reduce α-synuclein and TLR4, which led to improvement of motor deficits. The findings indicate that LPS can reduce insulin sensitivity through, at least in part, neuroinflammation and TLR4 overexpression, which leads to motor impairments. Suppression of TLR4 and activation of insulin receptor improve motor behaviors by restoration of these changes, suggesting TLR4 and insulin receptors are good therapeutic targets for PD modification.
Equilibrium and Kinetic Study on the Abolition of Hexavalent Chromium from Aqueous Solutions Utilizing Xanthated Tea Waste
Authors: Bista Dinesh , Joshi Padam , Chand Priyanka
Published: March 2023

Heavy metal removal is critically necessary to prevent water pollution. At various initial hexavalent chromium concentrations, adsorbent dosages, pHs, and contact periods, the removal of hexavalent chromium from aqueous solutions onto Xanthated Tea Waste was investigated. FTIR and XRD techniques were used to characterize the adsorbent. Hexavalent chromium was initially removed from aqueous solutions with an increase in adsorbent dosage and contact time, but it was shown that the adsorption of Cr (VI) was best at a contact period of 120 min and an adsorbent dose of 100 mg/L. In a similar manner, the amount of hexavalent chromium eliminated from the aqueous solutions increased as the hexavalent chromium concentration grew and decreased as the solution's pH increased, with pH 2.0 being the ideal. Using a pseudo second-order model, the kinetics of hexavalent chromium adsorption onto modified tea trash was studied. The adsorption equilibrium data were modeled using Langmuir isotherm models. The equilibrium results for the elimination of hexavalent chromium by modified tea trash were well represented by the Langmuir isotherm model. According to the isotherm analysis, the adsorption equilibrium fit the Langmuir isotherm well. At pH 2.0, the obtained maximum adsorption capacity was around 82%. According to the findings, chromium-containing aqueous solutions can be treated using Xanthated Tea Waste as a low-cost adsorbent.
Mechanistic Insights into Glycoside 3-Oxidases Involved in C-Glycoside Metabolism in Soil Microorganisms
Authors: Taborda André , Frazão Tomas , Rodrigues Miguel V. , Fernández-Luengo Xavier , Sancho Ferran , Lucas Maria Fátima , Frazão Carlos , Ventura M. Rita , Masgrau Laura , Borges Patrícia T. , Martins Ligia O
Published: March 2023

C-glycosides are natural products with important biological activities but are recalcitrant to degradation. Glycoside 3-oxidases (G3Oxs) are newly identified bacterial flavo-oxidases from the glucose-methanol-coline (GMC) superfamily that catalyze the oxidation of C-glycosides with the concomitant reduction of O2 to H2O2. This oxidation is followed by C-C acid/base-assisted bond cleavage in two-step C-deglycosylation pathways. Soil and gut microorganisms have different oxidative enzymes, but the details of their catalytic mechanisms are largely unknown. Here, we report that PsGO3x oxidizes at 50,000-fold higher specificity (kcat/Km) the glucose moiety of mangiferin to 3-keto-mangiferin than free D-glucose to 2-keto-glucose. Analysis of PsG3Ox X-ray crystal structures and PsGO3x in complex with glucose and mangiferin, combined with mutagenesis and molecular dynamics simulations, revealed distinctive features in the topology surrounding the active site that favors catalytically competent conformational states suitable for recognition, stabilization, and oxidation of the glucose moiety of mangiferin. Furthermore, their distinction to pyranose 2-oxidases (P2Oxs) involved in wood decay and recycling is discussed from an evolutionary, structural, and functional viewpoint.
Privacy-Preserving Federated Learning Framework using Permissioned Blockchain
Authors: Kasyap Harsh , Tripathy Somanath
Published: March 2023

Data is readily available with the growing number of smart and IoT devices. Industries of different sectors follow technological advancement to be benefited from data sharing. However, application-specific data is available in small chunks and distributed across demographics. Additionally, sharing data online brings serious concerns and poses various security and privacy threats. To address these issues, federated learning (FL), a secure and collaborative learning paradigm, would be suitable, which brings the machine learning model to the data owners. Unfortunately, FL is prone to poisoning and inference attacks in presence of malicious users and curious servers. This work proposes a permissioned blockchain based federated learning framework, called PrivateFL (Privacy-Preserving Federated Learning Framework). PrivateFL replaces the central server with a Hyperledger Fabric network, to prevent inference attacks. Further, we propose VPSA (Vertically Partitioned Secure Aggregation) tailored to PrivateFL framework, which performs robust and secure aggregation. PrivateFL facilitates multi-tenancy for learning different machine learning models. Theoretical analysis proves that the system is resistant against inference attacks, even if n-1 peers are compromised. A secure prediction mechanism is also proposed to securely query a global model and protecting its intellectual property rights. Experimental evaluation shows that PrivateFL performs better than the traditional (centralized) learning systems and converges faster, while capable enough to detect malicious updates.
Holistic Bursting Cells Store Long-term Memory in Auditory Cortex
Authors: Li Ruijie , Huang Junjie , Liang Susu , Liang Shanshan , Wang Meng , Liao Xiang , Lyu Jing , Zhou Zhenqiao , Jin Wenjun , Chen Haiyang , Holder Damaris , Liu Hongbang , Zhang Jianxiong , Li Min , Tang Yuguo , Remy Stefan , Pakan Janelle , Chen Xiaowei , Jia Hongbo
Published: March 2023

The sensory neocortex has been since long suggested to be a substrate for long-term memory storage, yet which exact cells store long-term memories remained neither known nor visible over a century. Here, using a combination of day-by-day two-photon Ca2+ imaging and targeted single-cell loose-patch recording in a non-fear auditory associative learning paradigm, we reveal sparsely distributed neurons in layer 2/3 of auditory cortex emerged step-wise from quiescence into bursting mode, which then invariably expressed a holistic information of the learned composite sounds, referred to as holistic bursting (HB) cells. Notably, it was not shuffled populations but the same sparse HB cells that causally embodied the behavioral relevance of the learned composite sounds, pinpointing HB cells as long-term memory storage in the sensory neocortex.
SPATIAL AND NYCTHEMERAL VARIATIONS OF ZOOPLANKTON IN URBAN AQUATIC ECOSYSTEMS OF DALOA (WEST-CENTRAL OF COTE DIVOIRE)
Authors:   Laboratory of Biodiversity and Tropical Ecology, UFR Environement, Jean Lorougnon Guede University, Cote dIvoire., Bi Boly Valerie NDO , Jean-Renaud Allouko ,   Laboratory of Biodiversity and Tropical Ecology, UFR Environement, Jean Lorougnon Guede University, Cote dIvoire., Jean-Marie Bertrand KOUE ,   Laboratory of Biodiversity and Tropical Ecology, UFR Environement, Jean Lorougnon Guede University, Cote dIvoire., Kotchi Yves BONY ,   Laboratory of Biodiversity and Tropical Ecology, UFR Environement, Jean Lorougnon Guede University, Cote dIvoire.
Published: March 2023

Urban aquatic ecosystems are important to many species. But they are more subject to urban anthropization which impacts the organisms living there. This study aims to determine the composition and zooplankton density of urban aquatic ecosystems in Daloa. Zooplankton were sampled in June and October 2020, by filtering 90 liters of water on a 50 Âµm mesh screen, from three fish ponds, three lakes, three streams and one pool. A total of 57 taxa, consisting of 29 Rotifers (50.88%), 17 Copepods (29.82%) and 11 Cladocerans (19.30%), were inventoried. The richness and density varied, depending on the ecosystems, respectively from 04 to 20 taxa and from 4.44 to 139.99 ind/L. These values were higher during the daytime than at night, and in October than in June. The highest taxonomic richness was obtained at ETPA pond (20 taxa), and the lowest at RUGO creek (04 taxa). The highest densities were obtained in the ponds (139.99 ind/L, 75.56 ind/L and 72.60 ind/L) and the lowest in the creeks (4.44 ind/L) and the pool (17.41 ind/L). Nauplii and copepodites and the cladoceran Alona sp. were most observed at night in the lakes. Redundancy analysis showed that the proliferation of some Rotifers and Copepods is optimal in relatively warm and alkaline water ecosystems. Although zooplankton richness is higher during the daytime, night-time sampling should not be overlooked as a way to expand zooplankton taxonomic databases.
LES MAROCAINS TALENTUEUX DE LOCCIDENT, DYNAMISME ENTREPRENEURIALET CROISSANCE NUMERIQUE : QUEL IMPACT POUR LE MAROC ?
Authors:   Chercheur au Departement Genie Electrique, Ecole Mohammedia dIngenieurs Universite Mohamed V Rabat, Morocco., Karim Brahim
Published: March 2023

Prosperous countries are those that have succeeded in putting in place incentives favorable to the emergence of productive entrepreneurship, which encourages the creation of value, knowledge and innovation. Conversely, less developed countries have an incentive structure that encourages unproductive and destructive entrepreneurship (rent seeking, corruption, low productivity). Recent academic research has provided empirical evidence that confirms the determining influence of the quality of institutions on the nature of entrepreneurial dynamics (Acemoglu, Johnson and Robinson 2004). Our study will focus on the impact of talented Moroccans and entrepreneurship on the knowledge economy in Morocco.
COMPARATIVE STUDY OF CONFORMAL HDR BRACHYTHERAPY WITH ICRU POINTS DOSES AND TOXICITY ASSESSMENT
Authors:   M.B.B.S Post-Graduate of Radiation Oncology, Guntur Medical College Guntur, Guntur District., Revathi Jakkula , Durga Prasad MD G. ,   Professor & HOD Radiation Oncology, Guntur Medical College, Guntur, Guntur District., V. Lakshmikeerthana Gundavarapu ,   M.B.B.S Post-Graduate of Radiation Oncology, Guntur Medical College Guntur, Guntur District.
Published: March 2023

Background: Toxicity assessment is done by comparing HDR brachytherapy with ICRU point doses. D2cc doses of OAR in HDR brachytherapy is slightly more than ICRU point doses. Objectives:The primary objective is volumetric dose assessment and toxicity comparison between ICRU point doses and HDR brachytherapy. Materials and Methods: It is a prospective comparative study. The total number of patients enrolled in the study is 20. After obtaining informed consent, then patients were enrolled in the study. All patients were diagnosed with H.P.E. positive squamous cell carcinoma of the Cervix from stage IIB to IIIB. Results: HDR brachytherapy-based D2cc of Rectum is more than ICRU point doses of the rectum. bladder doses does not show any significant changes. Conclusion: Comparatively HDR D2cc doses are more than conventional doses for rectum.
EFFECT OF VOLATILE OILS MIXTURE AND LASER RADIATION ON LIPID OXIDATION AND SHELF LIFE OF BEEF SAUSAGE DURING CRYOPRESERVATION
Authors:   Meat and Fish Technology Research Dept., Food Technology Research Institute, Agricultural Research Center, Giza, Egypt., Abd El-Reheemabd Rboh Ahmed , Hassan Helmy El-Said ,   National institute of Laser Enhanced Science (NILES) , Cairo University, Egypt., Saad Osheba Atef ,   Meat and Fish Technology Research Dept., Food Technology Research Institute, Agricultural Research Center, Giza, Egypt.
Published: March 2023

The aim of this research is to study the chemical components of cinnamon, rosemary, and clove volatile oils by GC/Mass as well as the antioxidant activity of these oils and their mixture by DPPH scavenging to select the best volatile oil or mixture for preparing beef sausage treated with laser rays (Helium-Neon laser wavelength 632.8 nm for 9 min for each side). Also, to study the effect of volatile oils mixture at 500 ppm and laser radiation on lipid oxidation and shelf-life of beef sausage during cold storage. Results indicated that 23, 10, and 18 compounds were identified from cinnamon, rosemary, and clove which represented 97.26, 98.50 and 98.80 %, respectively. Cinnamaldehyde, 1, 8 Cineole, and Eugenol were the most abundant chemical compounds in cinnamon, of cinnamon, rosemary, and clove volatile, respectively. Volatile oils mixture had significantly higher antioxidant activity than each volatile oil individual but significantly lowers than BHT as a synthetic antioxidant substance at all studied concentrations. Lipid oxidation (peroxide value, thiobarbituric acid, and acid value) of sausage treatments were not affected significantly by laser irradiation or volatile oils mixture immediately after processing (at zero time) but affected (p<0.5) during cold storage. Sausage treated with both laser irradiation and volatile oils mixture had significantly lower peroxide value, thiobarbituric acid and acid value than other sausage treatments at any time of cold storage. Also, laser irradiation plus the addition of volatile oils mixture caused high storage stability which increase the shelf-life of sausage to 20 days at 4Ã‚Â±1Ã‚ÂºC compared with sausage treated with volatile oils mixture only (15 days), sausage treated with laser rays only (10 days) and control sample (5 days).
BIOMECHANICS OF CAR CRASH RELATIONSHIP BETWEEN THE VEHICLE OCCUPANT AND THE VEHICLES RESTRAINT SYSTEM IN TIME OF A CRASH: SEAT BELT SYNDROME CASE REPORT
Authors:   Emmergency General Surgery Department, Ibn Sina Hospital, Rabart, Morocco., GRIDDA M.DYousra OUHAMMOU M.D Meriem , MAOUNI M.D Ilias ,   Emmergency General Surgery Department, Ibn Sina Hospital, Rabart, Morocco., AMRAOUI M.D Mohammed ,   Emmergency General Surgery Department, Ibn Sina Hospital, Rabart, Morocco.
Published: March 2023

The purpose of this article is to help surgeons understand and anticipate the pattern of injury, and biomechanics of the seat belt syndrome (SBS), better assess trauma patient and identify a patient who is more likely to have an underlying issue, caused by improper use of the seatbelt.We present a case of SBS occurring in a patient with a high BMI and an improper relaxed position, in context by a frontal car impact. The purpose is to use an example to describe the dynamic between the car occupant and the vehicle in case of a high-speed collision and what type of injury to expect.
BRIEF HYDROGEOLOGICAL STUDIES OF WATERSHED MR-21 IN CONTEXT OF GROUNDWATER ESTIMATION AND GROUNDWATER RECHARGE PLAN, OSMANABAD, MAHARASHTRA, INDIA
Authors:   Assistant Geologist, Groundwater Surveys and Development Agency, Osmanabad, Maharashtra, India., Shinde (Daga) Megha , P. Bhoyar Chandrakant ,   Senior Geologist, Groundwater Surveys and Development Agency, Survey Section, Pune, Maharashtra, India.
Published: March 2023

The global population is increasing rapidly and expected to touch the 9.5 billion mark by 2050 from the current 7.2 billion. The management of the groundwater resources is a challenging task worldwide against the backdrop of the growing water demand for industrial, agricultural, and domestic uses and shrinking resources. Moreover, this task has been hampered significantly due to declining/rising groundwater levels and associated contamination. A broad range of solutions could be considered to address the aforementioned problems of groundwater management strategy. This paper presents a comprehensive review on the Water level, Rainfall, Groundwater estimation and cropping pattern of the studied area which can be useful for applications of the management of groundwater resources and recharge techniques.It would also be necessary to plan, recharge and control the use of groundwater under the prevailing conditions. Publication and distribution of annual reports and related programmes for creating awareness amongst the community and for educating them will have to be undertaken regularly. This will enable avoiding scarcity in the studies area, as well as the hectic activity and excessive expenditure that has become characteristic of summer months in the marathwada and adjacent area. The present study discussed about the optimum planning of GW recharge and need to control the irrigation draft less than the recharge for future use. Application of Regulatory measures for not drilling bore wells. Optimum use of water saving practices. There should be annual GW budgeting on regular basis, need to plan cropping as per GW availability.
OUTCOME OF ACUTE TRAUMATIC EPIDURAL HEMATOMAS BASED ON THE GLASGOW COMA SCALE IN A RURAL SETTING
Authors: Dubey Shubham , Kumar Saikia Amrit , Rongpi Ranjib
Published: March 2023

Aim: To establish the correlation between initial GCS score and its impact on further management and outcome. Materials And Methods: A prospective study was done at department of surgery at Jmch from April 2021 to march 2022 on 30 patients after fulfilling inclusion and exclusion criteria. Data was collected using patient data sheets which were presented in tables and graph. Results: Out of 30 cases,23 males and 7 females were observed out of which maximum incidence observed at the age of 21 to 30 years with RTA being most common mode of injury. 17 patients were observed with gcs>13 of which 13 patients underwent conservative management. At the end of study all patients discharged with good outcome. Conclusions: Study shows incidence of EDH in MF about 2.74: 1.This study examined the factor for surgery from the clinical rather than radiologic perspective of initial EDH, which is not indicated for GCS score can be a factor for deciding the further management of EDH.
IMPACT OF SOCIAL MEDIA IN EDUCATING AND IMPROVING THE ORAL HEALTH STATUS IN CHILDREN
Authors: Kashyap Ketki , Mathur Shivani , Malik Manvi , Singh Kopal
Published: March 2023

Social media is an integral part of the communal fabric of todays world, from which health care is not excluded. Communication plays a vital role in breaking down barriers between the patient and dental health professional, and in strengthening the treatment alliance. It is increasingly becoming popular as a useful tool for health care providers to motivate and encourage patients of all ages groups and social backgrounds.
SUBCUTANEOUS NODULES WITH A GROUND GLASS ASPECT
Authors:   Department of Radiology, Mohammed V Military Hospital, Mohammed V University, Faculty of Medicine and Pharmacy of Rabat, Morocco., Belkouchi Lina , Saouab Rachida ,   Department of Radiology, Mohammed V Military Hospital, Mohammed V University, Faculty of Medicine and Pharmacy of Rabat, Morocco., El Fenni Jamal ,   Department of Radiology, Mohammed V Military Hospital, Mohammed V University, Faculty of Medicine and Pharmacy of Rabat, Morocco.
Published: March 2023

Polyarteritis nodosais a necrotic systemic vasculitis, it can manifest in its cutaneous form through ulcero-nerotic lesions with no other systemic manifestations. We report the case of a 73-year-old woman admitted for diffuse multifocal cutaneous lesions seen clinically and on CT scan corresponding to polyarteritis nodosa.
COMPARISON OF MECHANICAL PROPERTIES OF THE IMPLANT MATERIALS- TITANIUM, ZIRCONIUM AND PEEK USING THREE DIMENSIONAL FINITE ELEMENT ANALYSIS
Authors:   Senior Resident, Government Dental College, Kottayam., A. Harinee , C. Rajesh ,   Associate Professor, Government Dental College, Kottayam., Anilkumar S. ,   Controller of Examinations, Kerala University of Health Sciences., Raj Indu ,   Professor, Government Dental College, Kottayam., M. Raghavan Sandhya ,   Associate Professor, Government Dental College, Kottayam.
Published: March 2023

Background And Objective:Dental implants have been universally accepted as the best option for prosthetic rehabilitation of missing teeth.A material of choice for manufacturing dental implants was for long time commercially pure titanium due to its excellent bio compatibility and mechanical properties. Zirconia seems to be a suitable alternative dental implant material because of its tooth like color and biocompatibility. The most promising novel alternative to titanium is polyetheretherketone (PEEK) which is a partially crystalline poly aromatic linear thermoplastic substance. The objective of this study is to study and compare the mechanical properties of titanium, zirconium and PEEK implant materials using three dimensional finite element analysis. Methodology: A randomly chosen computerized tomography was used to obtain the digital model in the initial phase of the work. Only the part portion corresponding to tooth number 35 will be extracted from this model. Screwed cylindrical implants of length 12 mm and diameter 4mm will be modeled and simulated to be placed in the section of the bone. The different models used were model A - Titanium, model B â€“ Zirconium, and model C - PEEK implant models. All models were identical, except for the properties of the used materials and all were exported to the Ansys Workbench V10 finite elements simulation software. Vertical and oblique (45 degree) loads in relation to the long axis of the tooth with 100 N in magnitude were applied. Stress analysis performed by comparing the Von Mises stress components. Fatigue strength and mode of failure were also assessed for the three implant materials. Results: Maximum stress in the peri-implant bone when titanium implant was placed in 35 region was 281.40 Mpa under axial load of 100N. Maximum stress when zirconia implant was placed is 277.99 MPa and when peek implant was placed which amounts for 286.78Mpa. Titanium sustains more life cycle (832840.00) compared to Zirconium (743070.00) and PEEK has much less life cycle (302460.00). Factor of safety is rated on a scale of 0 -15 and results were Titanium (12.42) and Zirconium (11.16) had almost similar values. Peek (6.15) had low safety factor compared to Titanium and Zirconia. Conclusion:Titanium was superior to other two groups in all the properties considered. These results prove why Titanium is still considered to be the gold standard material of choice for dental implant fabrication.
NON-PHARMACOLOGICAL MANAGEMENT OF ZIGHTUDDAM QAWI (HYPERTENSION) IN UNANI SYSTEM OF MEDICINE
Authors:   [M.D (Unani-PCM), B.U.M.S, P.G.D.E.M.S], Associate Professor, Dept. of Ilaj-bit-Tadbeer (Regimenal Therapy), Inamdar Unani Medical College and Hospital, Chacha Layout, Sedam Road, Badepur, Kalaburagi (Gulbarga), Karnataka, 585105., Ameen Furquan , Imtiyazi N. ,   [M.D (Unani-PCM), B.U.M.S, P.G.D.E.M.S], Associate Professor, Dept. of Tahaffuzi-wa-Samaji Tib (PCM), Inamdar Unani Medical College and Hospital, Chacha Layout, Sedam Road, Badepur, Kalaburagi (Gulbarga), Karnataka, 585105., Akhtar Jamal ,   [M.D (Unani-Kulliyat-e-Tib), B.U.M.S], Associate Professor, Dept. of Kulliyat, Government Tibbi College and Hospital, Kadamkuan, Patna-3.
Published: March 2023

In Unani System of Medicine, the concept of Zightuddam Qawi (Hypertension) is described under the heading of Imtila (Congestion of fluid in the body) by many Unani physicians. Hypertension is basically a disease of blood vessels in which vessels have elevated pressure. The possible causes of this disease mentioned in Unani system of medicine are Sue Mizaj Damvi (abnormal sanguineous temperament), Sauda-e-Muhatriqa (burnt melanin) and Mizaj Haar Yabis (hot and dry temperament). In modern medicine, Hypertension is enlisted in the category of lifestyle disorders. The factors which predispose Hypertension include obesity, excessive salt intake, alcohol and smoking etc. In the view of Unani medicine, the non-pharmacological management of Hypertension can be achieved by Ilaj-bil-Ghiza (Dietotherapy) and Ilaj-bit-Tadbeer (Regimenal Therapy). The therapies which can be beneficial in the Hypertension are Fasd (Venesection), Hijamah (Cupping), Riyazat (Exercise), Dalak (Massage) and Hammam (Turkish bath/ Steam bath).
Pilgrimage as a form of transcendental communication: A study at the burial site of Habib Abdurrahman bin Abdullah Al-Habsyi
Authors: Jamil Achmad , Briandana Rizki , Hannan Ahmad , Mohd Sofian Muhammad Raqib
Published: March 2023

Transcendental communication is a part of ritual communication. This form of communication is the least discussed in the discipline of communication. This study discusses transcendental communication in a pilgrimage to the burial site of Habib Abdurrahman in Cikini, Jakarta. The paradigm of this study is a constructivist paradigm using a qualitative approach with a case study method. The techniques used for data collection are interviews, observation, literature study, and documentation. The results show that the meaning of pilgrimage as a medium for transcendental communication is built on three things, namely, communicative situations, communicative events, and communicative acts, all of which can be observed from the attitudes of the pilgrims. These three elements are based on spiritual values in Islamic religious beliefs strengthened by the Sunnah of the Prophet Muhammad and continued by generations after that until today. Thus, this study contributes to the existence of Islamic communication scholarship where every communication behavior in everyday life is always based on human personal communication with the creator.***Salah satu bentuk komunikasi ritual adalah komunikasi transendental. Bentuk komunikasi transendental ini paling sedikit dibicarakan dalam disiplin ilmu komunikasi. Studi ini bertujuan membahas komunikasi transendental dalam ziarah ke makam Habib Abdurrahman di Cikini, Jakarta. Paradigma pada penelitian ini adalah paradigma konstruktivis dengan menggunakan pendekatan kualitatif dengan metode studi kasus. Teknik pengumpulan data yang digunakan adalah wawancara, observasi, studi kepustakaan dan dokumentasi. Hasil penelitian menunjukkan makna ziarah sebagai media komunikasi transendental dibangun pada 3 hal yaitu, situasi komunikatif, peristiwa komunikatif, dan tindak komunikatif, yang ketiganya dapat diamati dari sikap para peziarah. Ketiga elemen itu didasari atas nilai-nilai spiritual dalam keyakinan agama Islam yang dikuatkan oleh Sunnah Nabi Muhammad dan dilanjutkan oleh generasi-generasi setelahnya sehingga saat ini. Dengan demikian, studi ini berkontribusi bagi eksistensi keilmuan komunikasi Islam dimana setiap perilaku komunikasi berbasis pada komunikasi personal manusia dengan sang pencipta.
Youth santri communication strategies to reduce uncertainty at the beginning of relationships with the opposite sex
Authors: Nugroho Ihwan Agung , Kusumajanti Kusumajanti , Irawatie Aniek
Published: March 2023

Communication between the opposite sex among Islamic boarding school students is a separate field in Islamic communication because they are governed by strict rules. This study aims to examine the communication strategies used by adolescents who are in Islamic boarding schools to reduce uncertainty at the beginning of their relationship. This study is interesting because santri are basically teenagers like teenagers in general. This study uses a quasi-qualitative method with a phenomenological approach. The research data was obtained through in-depth interviews conducted directly with six informants. The data is then analyzed by Uncertainty Reduction theory. The results of the research show that interpersonal communication is used as a strategy to reduce uncertainty. Interpersonal communication acts as a bridge of information and a means of confirming the correctness of data obtained by informants about the opposite sex, as well as bonding and enhancing closeness in relationships. This research also reveals that the basic reason for young students wanting to have a relationship is because they are curious and need someone to encourage them. This study contributes to the development of a communication strategy based on pesantren morals. The moral of the pesantren itself is one of the bases of the Islamic communication tradition.***Komunikasi antar lawan jenis dalam kalangan santri pesantren merupakan bidang tersendiri dalam komunikasi Islam karena mereka diatur oleh aturan pesantren yang ketat. Studi ini bertujuan untuk mengkaji strategi komunikasi yang digunakan oleh para remaja yang berada di dalam pondok pesantren guna mengurangi ketidakpastian pada awal hubungan mereka. Kajian ini menarik karena santri pada dasarnya adalah para remaja sebagaimana remaja pada umumnya.  Studi ini menggunakan metode quasi-kualitatif dengan pendekatan fenomenologi. Data penelitian ini diperoleh melalui wawancara mendalam yang dilakukan secara langsung kepada enam informan. Data tersebut kemudian dianalisis dengan teori Pengurangan Ketidakpastian. Hasil penelitian menunjukkan bahwa komunikasi antarpribadi digunakan sebagai strategi mengurangi ketidakpastian. Komunikasi antarpribadi berperan sebagai jembatan informasi dan sarana mengkonfirmasi kebenaran data yang diperoleh para informan tentang lawan jenisnya, juga sebagai perekat dan penambah kedekatan dalam hubungan. Studi ini juga mengungkap alasan mendasar santri remaja ingin menjalin hubungan adalah karena rasa ingin tahu dan membutuhkan sosok penyemangat. Kajian ini berkontribusi bagi pengembangan strategi komunikasi yang berbasis pada moral pesantren. Moral pesantren sendiri merupakan salah satu basis tradisi komunikasi Islam.