bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhanced antimicrobial activity of a peptide derived from human lysozyme by arylation of its tryptophan residues
Authors: González Rodrigo , Mendive‐Tapia Lorena , Pastrian María B , Albericio Fernando , Lavilla Rodolfo , Cascone Osvaldo , Iannucci Nancy B
Published: January 2016

Antimicrobial peptides are valuable agents to fight antibiotic resistance. These amphipatic species display positively charged and hydrophobic amino acids. Here, we enhance the local hydrophobicity of a model peptide derived from human lysozyme (107RKWVWWRNR115) by arylation of its tryptophan (Trp) residues, which renders a positive effect on Staphylococcus aureus and Staphylococcus epidermidis growth inhibition. This site‐selective modification was accessed by solid‐phase peptide synthesis using the non‐proteinogenic amino acid 2‐aryltryptophan, generated by direct C‐H activation from protected Trp. The modification brought about a relevant increase in growth inhibition: S. aureus was fully inhibited by arylation of Trp 112 and by only 10% by arylation of Trp 109 or 111, respect to the non‐arylated peptide. On the other hand, S. epidermidis was fully inhibited by the three arylated peptides and the parent peptide. The minimum inhibitory concentration was significantly reduced for S. aureus depending on the arylation site. Copyright © 2016 European Peptide Society and John Wiley & Sons, Ltd.
Back Cover: Band gap and broken chirality in single‐layer and bilayer graphene (Phys. Status Solidi RRL 1/2016)
Authors: Varlet Anastasia , Liu Ming‐Hao , Bischoff Dominik , Simonet Pauline , Taniguchi Takashi , Watanabe Kenji , Richter Klaus , Ihn Thomas , Ensslin Klaus
Published: January 2016

No abstract is available for this article.
pss– taking legacy to the future
Authors: Bahrs Sabine , Panarina Nadezda , Hildebrandt Stefan
Published: January 2016

No abstract is available for this article.
Anxiolytic Effect of Citrus aurantium L. on Patients with Chronic Myeloid Leukemia
Authors: Pimenta Flávia Cristina Fernandes , Alves Mateus Feitosa , Pimenta Martina Bragante Fernandes , Melo Silvia Adelaide Linhares , Almeida Anna Alice Figueirêdo de , Leite José Roberto , Pordeus Liana Clébia de Morais , Diniz Margareth de Fátima Formiga Melo , Almeida Reinaldo Nóbrega de
Published: January 2016

The bone marrow aspiration procedure is used in hematological diseases and consists of a painful, invasive procedure causing anxiety‐associated symptoms. The present study assessed the effect of Citrus aurantium L. essential oil on the treatment of anxiety, in the moment that precedes the collection of medullary material in patients with chronic myeloid leukemia (CML). Volunteers from both sexes were divided into groups receiving either the C. aurantium essential oil through inhalation, diazepam (10 mg), or the placebo. The evaluation was performed through psychometric scales [State‐Trait Anxiety Inventory (STAI)] and physiological measurements (blood pressure and cardiac and respiratory frequency). Inhalation of C. aurantium was associated with a decrease in the STAI‐S scores, suggesting an anxiolytic effect. In support of these results, a change in all the physiological measurements was observed in the group exposed to C. aurantium. In the diazepam group, only the diastolic pressure decreased, and no effect was observed in the placebo group. Therefore, the results showed that C. aurantium exhibits an anxiolytic effect and reduces the signs and symptoms associated with anxiety in patients with CML. Copyright © 2016 John Wiley & Sons, Ltd.
A chimeric α-amylase engineered from Bacillus acidicola and Geobacillus thermoleovorans with improved thermostability and catalytic efficiency
Authors: Parashar Deepak , Satyanarayana T
Published: January 2016

The α-amylase (Ba-amy) of Bacillus acidicola was fused with DNA fragments encoding partial N- and C-terminal region of thermostable α-amylase gene of Geobacillus thermoleovorans (Gt-amy). The chimeric enzyme (Ba-Gt-amy) expressed in Escherichia coli displays marked increase in catalytic efficiency [K  cat: 4 × 104 s−1 and K  cat/K  m: 5 × 104 mL−1 mg−1 s−1] and higher thermostability than Ba-amy. The melting temperature (T  m) of Ba-Gt-amy (73.8 °C) is also higher than Ba-amy (62 °C), and the CD spectrum analysis revealed the stability of the former, despite minor alteration in secondary structure. Langmuir–Hinshelwood kinetic analysis suggests that the adsorption of Ba-Gt-amy onto raw starch is more favourable than Ba-amy. Ba-Gt-amy is thus a suitable biocatalyst for raw starch saccharification at sub-gelatinization temperatures because of its acid stability, thermostability and Ca2+ independence, and better than the other known bacterial acidic α-amylases.
Characterization of representative rpoB gene mutations leading to a significant change in toyocamycin production of Streptomyces diastatochromogenes 1628
Authors: Ma Zheng , Luo Shuai , Xu Xianhao , Bechthold Andreas , Yu Xiaoping
Published: January 2016

Modification of enzymes involved in transcription- or translation-processes is an interesting way to increase secondary metabolite production in Streptomycetes. However, application of such methods has not been widely described for strains which produce nucleoside antibiotics. The nucleoside antibiotic toyocamycin (TM) is produced by Streptomyces diastatochromogenes 1628. For improving TM production in S. diastatochromogenes 1628, the strain was spread on rifamycin-resistant (Rifr) medium. Several spontaneous mutants were obtained with mutations in the rpoB gene which encodes a RNA polymerase β-subunit. The mutants which showed increased TM production were detected at a frequency of 7.5 % among the total Rifr mutants. Mutant 1628-T15 harboring amino acid substitution His437Arg was the best TM producer with a 4.5-fold increase in comparison to that of the wild-type strain. The worst producer was mutant 1628-T62 which also showed a poor sporulation behavior. RT-PCR was performed to study the transcription levels of the TM biosynthetic gene toyG in the parental strain as well as in mutants 1628-T15 and 1628-T62. The transcriptional level of toyG was higher in mutant 1628-T15 than that in parental strain 1628, while much lower in mutant 1628-T62. In mutant strain 1628-T62 the expression of adpA  sd gene, which is required for morphological differentiation, was also much lower. Our studies also indicate that the introduction of mutations into rpoB is an effective strategy to improve the production of TM which is an important nucleoside antibiotic.
Proteomics analysis of global regulatory cascades involved in clavulanic acid production and morphological development inStreptomyces clavuligerus
Authors: Ferguson Nicole L , Peña-Castillo Lourdes , Moore Marcus A , Bignell Dawn R D , Tahlan Kapil
Published: January 2016

The genus Streptomyces comprises bacteria that undergo a complex developmental life cycle and produce many metabolites of importance to industry and medicine. Streptomyces clavuligerus produces the β-lactamase inhibitor clavulanic acid, which is used in combination with β-lactam antibiotics to treat certain β-lactam resistant bacterial infections. Many aspects of how clavulanic acid production is globally regulated in S. clavuligerus still remains unknown. We conducted comparative proteomics analysis using the wild type strain of S. clavuligerus and two mutants (ΔbldA and ΔbldG), which are defective in global regulators and vary in their ability to produce clavulanic acid. Approximately 33.5 % of the predicted S. clavuligerus proteome was detected and 192 known or putative regulatory proteins showed statistically differential expression levels in pairwise comparisons. Interestingly, the expression of many proteins whose corresponding genes contain TTA codons (predicted to require the bldA tRNA for translation) was unaffected in the bldA mutant.
Does Shear Thickening Occur in Semisolid Metals?
Authors: Atkinson Helen V. , Favier Veronique
Published: January 2016

In the various forms of semisolid processing such as thixoforming and thixoforging, the entry into the die occurs in a fraction of a second so it is the transient rheological behavior which governs the initial stages of flow. In experiments in the literature, this rheological behavior is probed through applying rapid transitions in shear rate under isothermal conditions. There is contradictory evidence as to whether the behavior during these transitions is shear thinning or shear thickening, although it is clear that once in the die the material is thinning. Here the data in the literature are reanalyzed to obtain a rationalization of the contradictions which has not previously been available. It is argued that if a suspension is initially in a disagglomerated state (i.e., one which is initially sheared), the instantaneous behavior with a jump-up in shear rate is shear thickening (even if the long-term steady-state behavior is shear thinning) provided the fraction solid is greater than about 0.36 and the final shear rate at the end of the jump is greater than about 100 s−1. If the jump-up in shear rate is made from rest then yield masks the shear thickening.
Factors Correlating Outcome in Young Infants with Congenital Muscular Torticollis
Authors: Ryu Ji Hwa , Kim Dong Wook , Kim Seung Ho , Jung Hyun Seok , Choo Hye Jung , Lee Sun Joo , Park Young Mi , Baek Hye Jin
Published: January 2016

Purpose

No previous study using follow-up ultrasonography for evaluating the factors associated with the successful regression of congenital muscular torticollis in young infants has been published. This study aimed to assess clinical factors and sonographic features potentially influencing regression in patients with congenital muscular torticollis.

Methods

From January 2010 to December 2012, 80 infants underwent neck ultrasonography because of clinical suspicion of congenital muscular torticollis. We statistically analysed the correlation between complete resolution and clinicosonographic findings when complete resolution was defined as no visible lesion on follow-up ultrasonography.

Results

Of the 80 infants, 61 had congenital muscular torticollis and all were followed up by ultrasonography: 1) 34 underwent physiotherapy, and 27 of them (79.4%) revealed complete resolution in follow-up; 2) 27 did not undergo physiotherapy, and 15 of them (55.6%) showed complete resolution. A statistically significant correlation was found between physiotherapy and complete resolution, but not between complete resolution and patient sex; size, volume, and echogenicity of the lesion; and thickness ratio.

Conclusions

Physiotherapy was the only factor influencing complete resolution in young infants with congenital muscular torticollis.
Canadian Paediatric Neurology Workforce Survey and Consensus Statement
Authors: Doja Asif , Orr Serena L , McMillan Hugh J , Kirton Adam , Brna Paula , Esser Michael , Tang-Wai Richard , Major Philippe , Poulin Chantal , Prasad Narayan , Selby Kathryn , Weiss Shelly K. , Yeh E. Ann , Callen David JA
Published: January 2016

Background:Little knowledge exists on the availability of academic and community paediatric neurology positions. This knowledge is crucial for making workforce decisions. Our study aimed to: 1) obtain information regarding the availability of positions for paediatric neurologists in academic centres; 2) survey paediatric neurology trainees regarding their perceptions of employment issues and career plans; 3) survey practicing community paediatric neurologists 4) convene a group of paediatric neurologists to develop consensus regarding how to address these workforce issues.Methods:Surveys addressing workforce issues regarding paediatric neurology in Canada were sent to: 1) all paediatric neurology program directors in Canada (n=9) who then solicited information from division heads and from paediatric neurologists in surrounding areas; 2) paediatric neurology trainees in Canada (n=57) and; 3) community paediatric neurologists (n=27). A meeting was held with relevant stakeholders to develop a consensus on how to approach employment issues.Results:The response rate was 100% from program directors, 57.9% from residents and 44% from community paediatric neurologists. We found that the number of projected positions in academic paediatric neurology is fewer than the number of paediatric neurologists that are being trained over the next five to ten years, despite a clinical need for paediatric neurologists. Paediatric neurology residents are concerned about job availability and desire more career counselling.Conclusions:There is a current and projected clinical demand for paediatric neurologists despite a lack of academic positions. Training programs should focus on community neurology as a viable career option.
Derivation and Validation of the Surgical Site Infections Risk Model Using Health Administrative Data
Authors: van Walraven Carl , Jackson Timothy D. , Daneman Nick
Published: January 2016

OBJECTIVE

Surgical site infections (SSIs) are common hospital-acquired infections. Tracking SSIs is important to monitor their incidence, and this process requires primary data collection. In this study, we derived and validated a method using health administrative data to predict the probability that a person who had surgery would develop an SSI within 30 days.

METHODS

All patients enrolled in the National Surgical Quality Improvement Program (NSQIP) from 2 sites were linked to population-based administrative datasets in Ontario, Canada. We derived a multivariate model, stratified by surgical specialty, to determine the independent association of SSI status with patient and hospitalization covariates as well as physician claim codes. This SSI risk model was validated in 2 cohorts.

RESULTS

The derivation cohort included 5,359 patients with a 30-day SSI incidence of 6.0% (n=118). The SSI risk model predicted the probability that a person had an SSI based on 7 covariates: index hospitalization diagnostic score; physician claims score; emergency visit diagnostic score; operation duration; surgical service; and potential SSI codes. More than 90% of patients had predicted SSI risks lower than 10%. In the derivation group, model discrimination and calibration was excellent (C statistic, 0.912; Hosmer-Lemeshow [H-L] statistic, P=.47). In the 2 validation groups, performance decreased slightly (C statistics, 0.853 and 0.812; H-L statistics, 26.4 [P=.0009] and 8.0 [P=.42]), but low-risk patients were accurately identified.

CONCLUSION

Health administrative data can effectively identify postoperative patients with a very low risk of surgical site infection within 30 days of their procedure. Records of higher-risk patients can be reviewed to confirm SSI status.

Infect. Control Hosp. Epidemiol. 2016;37(4):455–465
The relationship between innovation and performance in special nonprofit firms: Social and cooperative agrifood firms
Authors: Chen Hsing Hung , Lee Amy H I , Chen Jack
Published: January 2016

Firms are continually trying to identify innovation sources in order to improve organizational performance, but the identification of such origins is a complex and poorly understood issue, particularly as far as nonprofit firms are concerned. The social and cooperative agrifood arrangement has become one of the main and newest types of nonprofit organization in China since the implementation of the law related to specialized cooperatives, on July 1, 2007. In this research, a conceptual model is proposed to show that the characteristics of innovative sources can determine a firm’s absorptive capacity, which in turn can impact its performance. Therefore, absorptive capacity can be expected to enable the mediation of the relationships of innovative sources with the performance of firms. By means of theoretical analysis and practical investigation, this paper provides an assessment of the use of innovation sources and finds critical factors that may foster competitive and sustainable advantages.
BUZANO’S INEQUALITY HOLDS FOR ANY PROJECTION
Authors: DRAGOMIR S. S.
Published: January 2016

We show that, in an inner product space$H$, the inequality$$\begin{eqnarray}{\textstyle \frac{1}{2}}[\Vert x\Vert \,\Vert y\Vert +|\langle x,y\rangle |]\geq |\langle Px,y\rangle |\end{eqnarray}$$is true for any vectors$x,y$and a projection$P:H\rightarrow H$. Applications to norm and numerical radius inequalities of two bounded operators are given.
Apple intake is inversely associated with all-cause and disease-specific mortality in elderly women
Authors: Hodgson Jonathan M. , Prince Richard L. , Woodman Richard J. , Bondonno Catherine P. , Ivey Kerry L. , Bondonno Nicola , Rimm Eric B. , Ward Natalie C. , Croft Kevin D. , Lewis Joshua R.
Published: January 2016

Higher fruit intake is associated with lower risk of all-cause and disease-specific mortality. However, data on individual fruits are limited, and the generalisability of these findings to the elderly remains uncertain. The objective of this study was to examine the association of apple intake with all-cause and disease-specific mortality over 15 years in a cohort of women aged over 70 years. Secondary analyses explored relationships of other fruits with mortality outcomes. Usual fruit intake was assessed in 1456 women using a FFQ. Incidence of all-cause and disease-specific mortality over 15 years was determined through the Western Australian Hospital Morbidity Data system. Cox regression was used to determine the hazard ratios (HR) for mortality. During 15 years of follow-up, 607 (41·7 %) women died from any cause. In the multivariable-adjusted analysis, the HR for all-cause mortality was 0·89 (95 % CI 0·81, 0·97) per sd (53 g/d) increase in apple intake, HR 0·80 (95 % CI 0·65, 0·98) for consumption of 5–100 g/d and HR 0·65 (95 % CI 0·48, 0·89) for consumption of >100 g/d (an apple a day), compared with apple intake of <5 g/d (Pfor trend=0·03). Our analysis also found that higher apple intake was associated with lower risk for cancer mortality, and that higher total fruit and banana intakes were associated lower risk of CVD mortality (P<0·05). Our results support the view that regular apple consumption may contribute to lower risk of mortality.
Unlike pregnant adult women, pregnant adolescent girls cannot maintain glycine flux during late pregnancy because of decreased synthesis from serine
Authors: Hsu Jean W. , Thame Minerva M. , Gibson Raquel , Baker Tameka M. , Tang Grace J. , Chacko Shaji K. , Jackson Alan A. , Jahoor Farook
Published: January 2016

During pregnancy, glycine and serine become more important because they are the primary suppliers of methyl groups for the synthesis of fetal DNA, and more glycine is required for fetal collagen synthesis as pregnancy progresses. In an earlier study, we reported that glycine flux decreased by 39 % from the first to the third trimester in pregnant adolescent girls. As serine is a primary precursor for glycine synthesis, the objective of this study was to measure and compare glycine and serine fluxes and inter-conversions in pregnant adolescent girls and adult women in the first and third trimesters. Measurements were made after an overnight fast by continuous intravenous infusions of 2H2-glycine and 15N-serine in eleven adolescent girls (17·4 (se 0·1) years of age) and in ten adult women (25·8 (se 0·5) years of age) for 4 h. Adolescent girls had significantly slower glycine flux and they made less glycine from serine in the third (P<0·05) than in the first trimester. Baby birth length was significantly shorter of adolescent girls (P=0·04) and was significantly associated with third trimester glycine flux. These findings suggest that the pregnant adolescent cannot maintain glycine flux in late pregnancy compared with early pregnancy because of decreased synthesis from serine. It is possible that the inability to maintain glycine synthesis makes her fetus vulnerable to impaired cartilage synthesis, and thus linear growth.
Quercetin lowers plasma uric acid in pre-hyperuricaemic males: a randomised, double-blinded, placebo-controlled, cross-over trial
Authors: Shi Yuanlu , Williamson Gary
Published: January 2016

Elevated plasma uric acid concentration is a risk factor for gout, insulin resistance and type 2 diabetes. Quercetin, a flavonoid found in high levels in onions, tea and apples, inhibits xanthine oxidoreductasein vitro, the final step in intracellular uric acid production, indicating that quercetin might be able to lower blood uric acid in humans. We determined the effects of 4 weeks of oral supplementation of quercetin on plasma uric acid, blood pressure and fasting glucose. This randomised, double-blinded, placebo-controlled, cross-over trial recruited twenty-two healthy males (19–60 years) with baseline plasma uric acid concentration in the higher, but still considered healthy, range (339 (sd51) µmol/l). The intervention included one tablet containing 500 mg quercetin daily for 4 weeks, compared with placebo, with a 4-week washout period between treatments. The primary outcome was change in concentrations of plasma uric acid after 2 and 4 weeks; secondary outcome measures were changes in fasting plasma glucose, 24-h urinary excretion of uric acid and resting blood pressure. After quercetin treatment, plasma uric acid concentrations were significantly lowered by −26·5 µmol/l (95 % CI, −7·6, −45·5;P=0·008), without affecting fasting glucose, urinary excretion of uric acid or blood pressure. Daily supplementation of 500 mg quercetin, containing the bioavailable amount of quercetin as present in approximately 100 g red onions, for 4 weeks, significantly reduces elevated plasma uric acid concentrations in healthy males.
Reproducibility and validity of an FFQ developed for adults in Nanjing, China
Authors: Ye Qing , Hong Xin , Wang Zhiyong , Yang Huafeng , Chen Xupeng , Zhou Hairong , Wang Chenchen , Lai Yichao , Sun Liuyuan , Xu Fei
Published: January 2016

We evaluated the reproducibility and validity of an FFQ used in a Chinese community-based nutrition and health survey. A total of ninety-nine males and 104 females aged 31–80 years completed four three consecutive 24-h dietary recalls (24-HDR, served as a reference method, one three consecutive 24-HDR for each season) and two FFQ (FFQ1 and FFQ2) over a 1-year interval. The reproducibility of the FFQ was estimated with correlation coefficients, misclassification and weighted κ statistic. The validity was evaluated by comparing the data obtained from FFQ2 with the mean 24-HDR (m24-HDR). Compared with the m24-HDR, the FFQ tended to underestimate intake of most nutrients and food groups. For all nutrients and food groups, the Spearman’s and intra-class correlation coefficients between FFQ1 and FFQ2 ranged from 0·66 to 0·88 and from 0·65 to 0·87, respectively. Most correlation coefficients decreased after adjusting for energy. More than 90 % of the subjects were classified into the same or adjacent categories by both FFQ. For all nutrients and food groups, the crude, energy-adjusted and de-attenuated Spearman’s correlation coefficients between FFQ2 and the m24-HDR ranged from 0·21 to 0·69, 0·19 to 0·58 and 0·25 to 0·71, respectively. More than 70 % of the subjects were classified into the same and adjacent categories by both instruments. Both weighted κ statistic and the Bland–Altman plots showed reasonably acceptable agreement between the FFQ2 and the m24-HDR. The FFQ developed for adults in the Nanjing area can be used to reliably and validly measure usual intake of major nutrients and food groups.
Rethinking Foreign Military Interventions to Promote Human Rights: Evidence from Libya, Bahrain and Syria
Authors: Nuruzzaman Mohammed
Published: January 2016

Scholarly opinions on the linkages between foreign military interventions and human rights promotions or violations are highly divided across the board. While many scholars see military interventions as effective means to save and promote human lives and rights from the clutches of repressive regimes, others reject such interventions as harmful to domestic reconciliations and rights promotions. The Arab Spring has renewed the debates between the liberal enthusiasts who staunchly supported NATO's military intervention to free up the Libyans from the Gaddafi regime and the critics who saw creeping dangers in this new intervention, ostensibly inspired by the “responsibility to protect” doctrine. This paper investigates the issue of Arab Spring-led foreign direct and indirect military interventions in Libya, Bahrain and Syria and critically examines the consequences of interventions for improvements or decline in Arab human rights conditions. Its findings support the position of the anti-intervention scholars that foreign military interventions produce deleterious effects on human rights in the target states.
Nationalism, “Philosemitism,” and Symbolic Boundary-Making in Contemporary Poland
Authors: Zubrzycki Geneviève
Published: January 2016

This article analyzes the growing interest in Jews and all things Jewish in contemporary Poland—from the spectacular popularity of festivals of Jewish culture to the opening of Judaica bookstores and Jewish cuisine restaurants; from the development of Jewish studies programs at various universities and the creation of several museums to artists’ and public intellectuals’ engagements with Poland's Jewish past and Polish-Jewish relations more broadly. Drawing on ethnographic fieldwork, over sixty formal interviews with Jewish and non-Jewish activists, and informal conversations with participants in various Jewish-centered initiatives, I argue that this cultural phenomenon is related to the attempt by specific political and social groups to build a pluralistic society in an ethnically and denominationally homogenous nation-state. I build on the literature on nationalism and symbolic boundaries by showing that bringing back Jewish culture and “resurrecting the Jew” is a way to soften, stretch, and reshape the symbolic boundaries of the nation that the Right wants to harden and shrink using Catholicism as its main tool.
Notes on a Scandal: Transregional Networks of Violence, Gossip, and Imperial Sovereignty in the Late Eighteenth-Century Ottoman Empire
Authors: Esmer Tolga U.
Published: January 2016

This essay reconstructs a scandal in the fall of 1797 involving Ottoman governors, leaders of a notorious network of irregular soldiers cum bandits, and residents of the city of Filibe (Plovdiv in Bulgaria). It erupted over whether or not state officials should pacify successful bandit enterprises by co-opting their leaders. The scandal escalated into a crisis in which the large armies of the governors of Anatolia and Rumeli (the Ottoman Balkans) verged on clashing because each wanted to lead the state's lucrative war against Rumeli bandit networks. Imperial administrators issued dispatches regarding this scandal that were based on gossip and rumor circulating within the general population as well as among bandits. I draw on understandings of gossip as a social and cultural resource from linguistic anthropology to make sense of Ottoman political culture. I analyze these dispatches to uncover how the performance of these informal scripts featured prominently in correspondence with the Imperial Council and related surveillance reports, and thereby mediated resources, power, and authority among different agents of imperial violence. I show that gossip, rumor, and related forms of seemingly informal “talk” played a fundamental role in sovereign decision making. I also transpose methodologies and approaches of “history from below,” conceived by earlier generations of cultural anthropologists and historians, onto elite letters to ask new questions about information brokerage, the negotiation of power among different agents of imperial violence and their interlocutors, and the contested nature of imperial intelligence gathering and sovereignty.
Constructing a Kongo Identity: Scholarship and Mythopoesis
Authors: MacGaffey Wyatt
Published: January 2016

The past thirty years have seen, particularly in the United States, a transformation in the public image of “Kongo,” an ill-defined entity (a tribe, a kingdom, a culture, a region?) on the Atlantic coast of Central Africa. The efforts of R. F. Thompson, professor of art history at Yale, and A. Fu-kiau, himself Kongolese, have done much to popularize a “Kongo” characterized more by its romantic appeal than by historical or ethnographic verisimilitude. Elsewhere in the Americas, the reputation of “Kongo” has suffered by comparison with “Yoruba,” another historically emergent Atlantic identity, based in West Africa. These identities, and the supposed contrast between them, are products of an increasingly complex trans-Atlantic discourse.
The potential of milk fatty acids as biomarkers for methane emissions in dairy cows: a quantitative multi-study survey of literature data
Authors: CASTRO-MONTOYA J. M. , DE CAMPENEERE S. , DE BAETS B. , FIEVEZ V.
Published: January 2016

Relationships between milk fatty acids (MFA) and methane (CH4) emissions from dairy cattle were explored. Data from a total of 12 studies including 39 treatments were gathered in the database. Methane was expressed as daily emissions (g/d), relative to dry matter intake (g/kg), milk production (g/kg milk) and body weight (g/kg). The univariate correlations between MFA and CH4 were based on absolute means and on relative changes of each treatment compared with its corresponding control. Saturated fatty acids, odd- and branched-chain FA and long-chain poly-unsaturated FA were positively related to CH4, while cis- and trans-isomers of mono-unsaturated FA were negatively related to CH4. However, most of the coefficients of determination (R2) of these univariate regressions ranged from 0·2 to 0·7, indicating that individual MFA only explain a limited part of the variation in CH4. Significant relationships between MFA and CH4 varied depending on the unit in which emissions were expressed. Similarly, some MFA seemed more suited to predict relative changes in CH4 emissions rather than absolute amounts. The present findings contribute to the exploration of the potential of MFA as biomarkers for CH4 emissions from dairy cattle, although differences between studies in the detail of MFA analysis and hence the number of MFA reported in the current study, complicates this kind of literature survey.
Microzooplankton and meroplanktonic larvae at two seamounts in the subtropical and tropical NE Atlantic
Authors: Denda A. , Mohn C. , Wehrmann H. , Christiansen B.
Published: January 2016

Spatial distribution patterns of microzooplankton (0.055–0.3 mm) biomass and abundance were studied in relation to the hydrographic situation and the local flow field in the waters off Ampère and Senghor, two shallow seamounts in the subtropical and tropical NE Atlantic, in comparison with unaffected open ocean reference sites. Ampère was sampled during November/December 2010 and Senghor during December 2011 and February 2013. The study includes taxonomic composition, abundance of meroplanktonic larvae and an estimation of the respiratory carbon demand. Biomass (dry weight) standing stocks of microzooplankton in the upper 100 m ranged between 30–120 mg m−2 over Ampère and 140–260 mg m−2 over Senghor Seamount, corresponding to 33 and 24% of the total zooplankton (0.055–20 mm). Highest total abundance was always found in the upper 50 m with numbers of 1070–5060 Ind m−3 at Ampère and 5050–20,000 Ind m−3 at Senghor with microzooplankton contributing 70–95%. Zooplankton accumulated mainly at the thermocline coincident with the deep fluorescence maximum and was ascertained by food supply rather than by oxygen limitation. The microzooplankton contribution to the total respiratory carbon demand was ~50% in the subtropical waters off Ampère and ~30% at Senghor, reflecting the important role of microzooplankton in the waters of the NE Atlantic subtropical gyre. Clear evidence of local seamount effects resulting in enhanced microzooplankton biomass compared with the unaffected reference sites were not detected. However, we confirmed Senghor as a hotspot for meroplanktonic larvae, suggesting a retention potential that results in significantly enhanced larval abundance in the seamount waters as compared with the open ocean.
Disruptive mood dysregulation disorder at the age of 6 years and clinical and functional outcomes 3 years later
Authors: Dougherty L. R. , Smith V. C. , Bufferd S. J. , Kessel E. M. , Carlson G. A. , Klein D. N.
Published: January 2016

Background

Little is known about the predictive validity of disruptive mood dysregulation disorder (DMDD). This longitudinal, community-based study examined associations of DMDD at the age of 6 years with psychiatric disorders, functional impairment, peer functioning and service use at the age of 9 years.

Method

A total of 473 children were assessed at the ages of 6 and 9 years. Child psychopathology and functional impairment were assessed at the age of 6 years with the Preschool Age Psychiatric Assessment with parents and at the age of 9 years with the Kiddie-Schedule of Affective Disorders and Schizophrenia (K-SADS) with parents and children. At the age of 9 years, mothers, fathers and youth completed the Child Depression Inventory (CDI) and the Screen for Child Anxiety Related Disorders, and teachers and K-SADS interviewers completed measures of peer functioning. Significant demographic covariates were included in all models.

Results

DMDD at the age of 6 years predicted a current diagnosis of DMDD at the age of 9 years. DMDD at the age of 6 years also predicted current and lifetime depressive disorder and attention-deficit/hyperactivity disorder (ADHD) at the age of 9 years, after controlling for all age 6 years psychiatric disorders. In addition, DMDD predicted depressive, ADHD and disruptive behavior disorder symptoms on the K-SADS, and maternal and paternal reports of depressive symptoms on the CDI, after controlling for the corresponding symptom scale at the age of 6 years. Last, DMDD at the age of 6 years predicted greater functional impairment, peer problems and educational support service use at the age of 9 years, after controlling for all psychiatric disorders at the age of 6 years.

Conclusions

Children with DMDD are at high risk for impaired functioning across childhood, and this risk is not accounted for by co-morbid conditions.
Ethical Dilemmas in Postnatal Treatment of Severe Congenital Hydrocephalus
Authors: WILKINSON DOMINIC
Published: January 2016

Severe congenital hydrocephalus manifests as accumulation of a large amount of excess fluid in the brain. It is a paradigmatic example of a condition in which diagnosis is relatively straightforward and long-term survival is usually associated with severe disability. It might be thought that, should parents agree, palliative care and limitation of treatment would be clearly permissible on the basis of the best interests of the infant. However, severe congenital hydrocephalus illustrates some of the neuroethical challenges in pediatrics. The permissibility of withholding or withdrawing treatment is limited by uncertainty in prognosis and the possibility of “palliative harm.” Conversely, although there are some situations in which treatment is contrary to the interests of the child, or unreasonable on the grounds of limited resources, acute surgical treatment of hydrocephalus rarely falls into that category.
Thriving in Adversity
Authors: SHELDON CURTIS
Published: January 2016

This article is intended to highlight the unique vulnerability associated with a
severe medical illness. It outlines important considerations that are relevant
to patients but perhaps especially relevant to medical providers. There are many
factors that contribute to recovery from a life-threatening illness. Essential,
but underestimated, factors include (1) a vision for what the meaning of your
life can be; (2) simple and unexpected acts of kindness that underscore the
commitment of your providers to your well-being; and (3) the character of
providers and the culture of the institution, which vary tremendously and are
palpable to the patient.
Glial fibrillary acidic protein as a biomarker for brain injury in neonatal CHD
Authors: McKenney Stephanie L. , Mansouri Fahad F. , Everett Allen D. , Graham Ernest M. , Burd Irina , Sekar Priya
Published: January 2016

Neonates with critical CHD have evidence, by imaging, of preoperative brain injury, although the timing is unknown. We used circulating postnatal serum glial fibrillary acidic protein as a measure of acute perinatal brain injury in neonates with CHD. Glial fibrillary acidic protein was measured on admission and daily for the first 4 days of life in case and control groups; we included two control groups in this study – non-brain-injured newborns and brain-injured newborns. Comparisons were performed using the Kruskal–Wallis test with Dunn’s multiple comparisons, Student’s t-test, and χ2 test of independence where appropriate. In aggregate, there were no significant differences in overall glial fibrillary acidic protein levels between CHD patients (n=56) and negative controls (n=23) at any time point. By day 4 of life, 7/56 (12.5%) CHD versus 0/23 (0%) normal controls had detectable glial fibrillary acidic protein levels. Although not statistically significant, the 5/10 (50%) left heart obstruction group versus 1/17 (6%) conoventricular, 0/13 (0%) right heart, and 1/6 (17%) septal defect patients trended towards elevated levels of glial fibrillary acidic protein at day 4 of life. Overall, glial fibrillary acidic protein reflected no evidence for significant peripartum brain injury in neonates with CHD, but there was a trend for elevation by postnatal day 4 in neonates with left heart obstruction. This pilot study suggests that methods such as monitoring glial fibrillary acidic protein levels may provide new tools to optimise preoperative care and neuroprotection in high-risk neonates with specific types of CHD.
Computer-aided auscultation of murmurs in children: evaluation of commercially available software
Authors: Lee Cecilia , Rankin Kathryn N. , Zuo Kevin J. , Mackie Andrew S.
Published: January 2016

Background

Heart murmurs are common in children and may represent congenital or acquired cardiac pathology. Auscultation is challenging and many primary-care physicians lack the skill to differentiate innocent from pathologic murmurs. We sought to determine whether computer-aided auscultation (CardioscanTM) identifies which children require referral to a cardiologist.

Methods

We consecutively enrolled children aged between 0 and 17 years with a murmur, innocent or pathologic, being evaluated in a tertiary-care cardiology clinic. Children being evaluated for the first time and patients with known cardiac pathology were eligible. We excluded children who had undergone cardiac surgery previously or were unable to sit still for auscultation. CardioscanTMauscultation was performed in a quiet room with the subject in the supine position. The sensitivity and specificity of a potentially pathologic murmur designation by CardioscanTM– that is, requiring referral – was determined using echocardiography as the reference standard.

Results

We enrolled 126 subjects (44% female) with a median age of 1.7 years, with 93 (74%) having cardiac pathology. The sensitivity and specificity of a potentially pathologic murmur determination by CardioscanTMfor identification of cardiac pathology were 83.9 and 30.3%, respectively, versus 75.0 and 71.4%, respectively, when limited to subjects with a heart rate of 50–120 beats per minute. The combination of a CardioscanTMpotentially pathologic murmur designation or an abnormal electrocardiogram improved sensitivity to 93.5%, with no haemodynamically significant lesions missed.

Conclusions

Sensitivity of CardioscanTMwhen interpreted in conjunction with an abnormal electrocardiogram was high, although specificity was poor. Re-evaluation of computer-aided auscultation will remain necessary as advances in this technology become available.
Longitudinal Evaluation of Cognitive Functioning in Young Children with Type 1 Diabetes over 18 Months
Authors: Cato M. Allison , Mauras Nelly , Mazaika Paul , Kollman Craig , Cheng Peiyao , Aye Tandy , Ambrosino Jodie , Beck Roy W. , Ruedy Katrina J. , Reiss Allan L. , Tansey Michael , White Neil H. , Hershey Tamara
Published: January 2016

Objectives:Decrements in cognitive function may already be evident in young children with type 1 diabetes (T1D). Here we report prospectively acquired cognitive results over 18 months in a large cohort of young children with and without T1D.Methods:A total of 144 children with T1D (mean HbA1c: 7.9%) and 70 age-matched healthy controls (mean age both groups 8.5 years; median diabetes duration 3.9 years; mean age of onset 4.1 years) underwent neuropsychological testing at baseline and after 18-months of follow-up. We hypothesized that group differences observed at baseline would be more pronounced after 18 months, particularly in those T1D patients with greatest exposure to glycemic extremes.Results:Cognitive domain scores did not differ between groups at the 18 month testing session and did not change differently between groups over the follow-up period. However, within the T1D group, a history of diabetic ketoacidosis (DKA) was correlated with lower Verbal IQ and greater hyperglycemia exposure (HbA1c area under the curve) was inversely correlated to executive functions test performance. In addition, those with a history of both types of exposure performed most poorly on measures of executive function.Conclusions:The subtle cognitive differences between T1D children and nondiabetic controls observed at baseline were not observed 18 months later. Within the T1D group, as at baseline, relationships between cognition (Verbal IQ and executive functions) and glycemic variables (chronic hyperglycemia and DKA history) were evident. Continued longitudinal study of this T1D cohort and their carefully matched healthy comparison group is planned. (JINS, 2016,21, 293–302)
TIME-VARYING COEFFICIENT MODELS: A PROPOSAL FOR SELECTING THE COEFFICIENT DRIVER SETS
Authors: Hall Stephen G. , Swamy P. A. V. B. , Tavlas George S.
Published: January 2016

Coefficient drivers are observable variables that feed into time-varying coefficients (TVCs) and explain at least part of their movement. To implement the TVC approach, the drivers are split into two subsets, one of which is correlated with the bias-free coefficient that we want to estimate and the other with the misspecification in the model. This split, however, can appear to be arbitrary. We provide a way of splitting the drivers that takes account of any nonlinearity that may be present in the data, with the aim of removing the arbitrary element in driver selection. We also provide an example of the practical use of our method by applying it to modeling the effect of ratings on sovereign-bond spreads.
Interaction of bilingualism and Attention-Deficit/Hyperactivity Disorder in young adults
Authors: BIALYSTOK ELLEN , HAWRYLEWICZ KORNELIA , WISEHEART MELODY , TOPLAK MAGGIE
Published: January 2016

One hundred and sixty-eight young adult participants were classified as monolingual or bilingual and as having a previously reported clinical diagnosis of ADHD or not to create four groups. All participants completed tests of language proficiency, ADHD ratings, and executive control. Both bilingualism and ADHD are generally associated with poorer vocabulary knowledge, but bilingualism and ADHD are associated with opposite effects on executive control. Consistent with this literature, bilinguals performed more poorly than monolinguals on the vocabulary test but contrary to predictions, the ADHD group performed somewhat better on language ability than the non-ADHD group, attesting to their high functioning status. For the flanker task, both bilinguals and non-ADHD participants showed less cost in performing in the conflict condition than in the baseline condition. For the stop-signal task, ADHD status interfered more with performance by bilinguals than monolinguals, suggesting a greater burden of ADHD on executive function for this group.
The global coverage of prevalence data for mental disorders in children and adolescents
Authors: Erskine H. E. , Baxter A. J. , Patton G. , Moffitt T. E. , Patel V. , Whiteford H. A. , Scott J. G.
Published: January 2016

Aims.

Children and adolescents make up almost a quarter of the world's population with 85% living in low- and middle-income countries (LMICs). Globally, mental (and substance use) disorders are the leading cause of disability in young people; however, the representativeness or ‘coverage’ of the prevalence data is unknown. Coverage refers to the proportion of the target population (ages 5–17 years) represented by the available data.

Methods.

Prevalence data for conduct disorder (CD), attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorders (ASDs), eating disorders (EDs), depression, and anxiety disorders were sourced from systematic reviews conducted for the Global Burden of Disease Study 2010 (GBD 2010) and 2013 (GBD 2013). For each study, the location proportion was multiplied by the age proportion to give study coverage. Location proportion was calculated by dividing the total study location population by the total country population. Age proportion was calculated by dividing the population of the country aged within the age range of the study sample by the country population aged 5–17 years. If a study only sampled one sex, study coverage was halved. Coverage across studies was then summed for each country to give coverage by country. This method was repeated at the region and global level, and separately for GBD 2013 and GBD 2010.

Results.

Mean global coverage of prevalence data for mental disorders in ages 5–17 years was 6.7% (CD: 5.0%, ADHD: 5.5%, ASDs: 16.1%, EDs: 4.4%, depression: 6.2%, anxiety: 3.2%). Of 187 countries, 124 had no data for any disorder. Many LMICs were poorly represented in the available prevalence data, for example, no region in sub-Saharan Africa had more than 2% coverage for any disorder. While coverage increased between GBD 2010 and GBD 2013, this differed greatly between disorders and few new countries provided data.

Conclusions.

The global coverage of prevalence data for mental disorders in children and adolescents is limited. Practical methodology must be developed and epidemiological surveys funded to provide representative prevalence estimates so as to inform appropriate resource allocation and support policies that address mental health needs of children and adolescents.
Quantifying the origin of metallic glass formation
Authors: Johnson W. L. , Na J. H. , Demetriou M. D.
Published: January 2016

The waiting time to form a crystal in a unit volume of homogeneous undercooled liquid exhibits a pronounced minimum τX* at a ‘nose temperature’ T* located between the glass transition temperature Tg, and the crystal melting temperature, TL. Turnbull argued that τX* should increase rapidly with the dimensionless ratio trg=Tg/TL. Angell introduced a dimensionless ‘fragility parameter’, m, to characterize the fall of atomic mobility with temperature above Tg. Both trg and m are widely thought to play a significant role in determining τX*. Here we survey and assess reported data for TL, Tg, trg, m and τX* for a broad range of metallic glasses with widely varying τX*. By analysing this database, we derive a simple empirical expression for τX*(trg, m) that depends exponentially on trg and m, and two fitting parameters. A statistical analysis shows that knowledge of trg and m alone is therefore sufficient to predict τX* within estimated experimental errors. Surprisingly, the liquid/crystal interfacial free energy does not appear in this expression for τX*.