bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of probiotics on intestinal microflora of patients with hiv
Authors: Gorobchenko K. N. , Dyachenko A. G. , Savinova O. M. , Ivakhnjuk T. V.
Published: March 2023

HIV-1 infection results in structural damage to the intestinal mucosa and changes of gut microflora following dysfunction of the gastrointestinal system, including compromised barrier function. Known properties of probiotics suggest that they may be useful tools in restoring normal intestinal flora. Our study goal was to determine whether the use of a probiotics can recover normal gut flora in chronically HIV-infected adults. Standard bacteriological methods were used to exam the gut microbial content of the HIV-infected patients. Changes of intestinal microbiota were found in all of the patients. In the most cases the decrease of obligatory microorganisms, especially Bifidobacterium spp. (in 90 % of patients) was found. Overgrowth of major opportunistic pathogens (S. aureus and Candida spp.) was registered in only a minority of patients. The probiotic interventions resulted in significantly elevated levels of beneficial bacteria load (such as Bifidobacterium spp., Lactobacillus spp.) and a decrease in patogenic bacteria load (such as Clostridium, Candida spp.). Probiotic preparations can successfully augment the levels of beneficial species in the gut during chronic HIV-1 infection. These findings may help inform future studies aimed at testing pre- and probiotic approaches to improve gut function and mucosal immunity in chronic HIV-1 infection.
Magnesium deficiency and stress
Authors: Kniazkova I. I. , Bogun M. V. , Golovachova V. A. , Leshchyna I. V.
Published: March 2023

Magnesium deficiency is observed in many physiological and pathological conditions (imbalanced diet, diabetes, cardiovascular diseases, etc.). Magnesium ions are of great importance in the realization of immune reactions, inflammation, nervous and muscular excitability. The deficiency of magnesium is one of the main causes of stress and low stress resistance. Reduction of magnesium content destabilizes the systems responsible for adaptation and facilitates its sensitization, what determines anxiety and high stress level of patients. Understanding the mechanisms of magnesium involvement in the pathogenesis of stress and the development of a stress reaction will allow a family physician to assess the clinical manifestations of magnesium deficiency early in order to provide proper therapy for its correction.
Leptin and insulin resistance in patients with osteoarthritis combined with obesity and the dynamics of their levels on the background of treatment with symptomatic fast-acting drugs (sodium naproxen)
Authors: Kuryata O. V. , Cherkasova G. V.
Published: March 2023

The aim – to assess the level of leptin and insulin resistance in patients with osteoarthritis depending on obesity and the effect of treatment with naproxen sodium. Materials and methods. The study was conducted at the Department of Rheumatology of the MI "Mechnikov Dnipropetrovsk Regional Clinic". The study included 30 women with OA aged 40 to 75 years with OA I-III X-ray stage according to Kellgren and Lawerence with synovitis phenomena; the pain level for the visual analogue scale (VAS) > 3 points; obesity I-III degree (body mass index – BMI 30–49.9 kg/m2) after receiving their informed consent. Results. Obesity among patients with OA was associated with higher pain level in knees using VAS. The degree of motor limitations in the WOMAC index increased proportionally with the increase in BMI. The level of systemic inflammation in OA patients with obesity was significantly higher. Treatment with naproxen significantly reduced the level of leptin, regardless of obesity. Conclusions. The use of naproxen sodium (naproff) in patients with OA with synovitis leads to a pronounced analgesic and anti-inflammatory effects. Leptin plays an important role in the formation of insulin resistance and maintenance of low-level inflammation in OA in obese individuals.
Research of the pharmacological activity of capsules diaplant
Authors: Fares R. , Bobrytska L. A. , Drogovoz S. M. , Popova N .V. , Shpychak O. S. , Hrytsenko V. I. , Ivko T. I. , Kononenko A. V.
Published: March 2023

We developed the new сomplex drug diaplant in capsules for pharmacotherapy of acute intestinal infections. Diaplant consist of the nifuroxazide 200 mg and pantaglucidum 200 mg (leaf extract of Plantago major). Antiexudative activity of diaplant was established on the model of carrageenan edema. A comparative drug for the dynamics of antiexudative activity was sodium diclofenac in tablets («Novartis pharma», Sweden). As a result of the experiment, the maximum activity was on the third hour and was 43.1 % in diaplant, and was 64.4 % for sodium diclofenac. Spasmolytic activity of diaplant was studied by the method of «carbon labels». It has been found the identity of indicators for capsules diaplant with comparative drug plantaglucid (Zdorovye, Ukraine).
Holocaust Memory Memorials and the Visual Arts in the Netherlands
Authors: Cahen Joël J.
Published: March 2023

This article analyses key changes in public memory in the Netherlands. Its examination of memorials, and their relationships to official memory and creative practices, shows a gradual shift in focus from war heroes to collective and individual victims of the Nazi persecution. The second part of the article focuses on contemporary visual artists, whose works are inspired by their own family histories and by changing attitudes to the memory of the Shoah, which has gained increasing public visibility. In line with the changes observed in some memorials, their artworks demonstrate a key development of Holocaust remembrance since the end of the war, with a shift in emphasis towards remembering individual victims and circumstances. This shows a transition from commemorating the unpronounceable through symbols, towards a detailed memorialising of the Shoah through the names of victims and minute reconstructions via maps, models and portraits.
The Jewish secOnd generation art & family Museum Amsterdam
Authors: van der Heijden Maarten K.
Published: March 2023

The Jewish secOnd generation art & family Museum Amsterdam (JOMA) opened in 2022. It combines the artwork of Maarten van der Heijden with the stories of his Jewish family. This article presents the various stages of van der Heijden's work and elucidates his practice as a second-generation artist, drawing on the notions of postmemory and sublimation. The article concludes by discussing the JOMA as a highly personal as well as a collective memory project and its role in human rights education.
Rabbi Dr Tovia Ben-Chorin z'l
Authors: Magonet Jonathan
Published: March 2023

Rabbi Tovia Ben-Chorin was born on 15 September 1936 in Jerusalem, the son of journalist and religious scholar Schalom Ben-Chorin (formerly Fritz Rosenthal) and artist Gabriella Rosenthal, the couple having moved from Germany to Palestine in 1935. He graduated with a BA in Bible and Jewish studies from the Hebrew University, Jerusalem and was ordained as a rabbi by Hebrew Union College-Jewish Institute of Religion in Cincinnati in 1964. He served initially as a rabbi in Israel in Ramat Gan, then in Manchester Reform Synagogue, Jackson's Row (1977–81), and from 1981 to 1996 at the Har El congregation in Jerusalem, which he had helped to establish with his father and stepmother, and which became the ‘mother community’ of today's Israel Movement for Progressive Judaism (IMPJ). During this period, he established the Israeli Progressive Youth Movement and guided the ‘garin’ which established the second Reform kibbutz in the Arava, Kibbutz Lotan. He has written that ‘wanderlust’ led him to become the rabbi of Or Chadash congregation in Zurich (1997–2007) and subsequently Berlin's Pestalozzi Strasse Liberal synagogue from 2009 to 2015, and to a small congregation in St Gallen in Switzerland where he served until his death.
KENTSEL TARIM LİTERATÜRÜ ÜZERİNE BİBLİYOMETRİK BİR ANALİZ
Authors: GÜRSOY Özgür Burçak , ÇOLAK Ezgi
Published: March 2023

Kentsel tarım, farklı ölçek ve amaçları kapsayacak şekilde kentsel alanlarda yapılan tarımsal faaliyetleri kapsamaktadır. Pandemi, iklim değişiklikleri, gıda güvenliğine dönük dışsal şoklar ve kentlerin gıda ihtiyacına ilişkin artan kaygılar, kentsel tarım kavramına olan ilginin artışına neden olmuştur. Bu makalede, WOS Core Collection veri tabanından elde edilen bibliyometrik bilgilere dayanarak kentsel tarıma dair uluslararası bilimsel alan yazının bir taraması sunulmaktadır. Bibliyometrik veri, 2000 yılı sonrasında bilimsel dergilerde İngilizce yayınlanmış makalelerde konu bakımından yapılan taramada elde edilen 2.225 makalenin bilgisini içermektedir. Analizde VOS Viewer programı kullanılmış ve zaman, ülke, yazar, anahtar kelime ağı, atıf sayısı, ülke ve yazar atıf ağı bakımından incelenmiştir. Elde edilen bulgulara göre, coğrafi olarak en çok Amerika, Kanada, Çin ve Kıta Avrupası ülkelerine odaklanan makale sayısında özellikle 2017 sonrası ciddi bir artış yaşanmıştır. Atıf ağında en büyük kümelenmenin Amerika etrafında olduğu, anahtar kelime ağında çalışmaların disiplinler arası yapısını gösterir şekilde yönetim ve çevre bilimlerinden eşleşmeler olduğu ve yazar atıf ağında özellikle McClintock, Bueckert ve Rieradevall’in etrafındaki kümelenmelerin öne çıktığı görülmüştür. Bu makale, önümüzdeki yıllarda tarımsal üretimin mekânsal örgütlenişine dair teorik perspektifler ve uygulanacak politikalar açısından son derece önemli bir mecra olacak kentsel tarım literatürünün güncel durumunu ortaya koyarak yeni araştırmalar için bir zemin sunmuştur.
Carbon fiber lumbopelvic reconstruction following sacral giant cell tumor resection: illustrative case
Authors: Raso Jon , Chi Jialun , Labaran Lawal A. , Frank Charles , Shen Francis H.
Published: March 2023

BACKGROUND

The use of carbon fiber or polyetheretherketone spine constructs has proven to be a safe and effective alternative to standard metal alloy. The mechanical properties of carbon fiber while unique provide a construct that is comparable in strength to previous titanium-based constructs and have additionally shown greater fatigue resistance. These constructs have been especially useful for the mechanical stabilization of the spine following tumor resection. The subsequent interference seen when imaging a patient with a traditional metallic construct is reduced and allows for improved tumor surveillance after the procedure, and a more accurate delivery of radiotherapy when indicated.

OBSERVATIONS

This case report details the treatment of a 25-year-old female diagnosed with a sacral giant cell tumor. The authors discuss the use of a carbon fiber-reinforced polyetheretherketone for lumbopelvic reconstruction.

LESSONS

Carbon fiber-reinforced polyetheretherketone with its radiolucency and rigidity is a reliable option for complex spinal reconstruction after tumor resection.
MOBILE MULTIMEDIA COMPLEX ONIКO USING PRINCIPLES AT THE DEPARTMENT OF HUMAN ANATOMY POLTAVA STATE MEDICAL UNIVERSITY
Authors: Hryn V. H. , Fedorchenko I. L. , Lytovka V. V.
Published: March 2023

Human anatomy is learnt within the cycle of disciplines for general training of professionals in the field of health care. Learning human anatomy is provided through lectures and practical classes, which are supported by various technical teaching aids. All these tools and softwares are designed to foster clinical thinking and clinical. The methodological functions of these teaching aids are strongly related to the specifics of teaching human anatomy at medical schools or universities and to the real-life conditions simulate through the educational process.

Interactive forms of teaching and learning are designed to facilitate solving the tasks outlined by the practice-oriented approach in the modern education. The guiding principle in the process of studying human anatomy is the principle of visualization. At present there are a large number of computer programs and applications for electronic devices allowing students to deepen their knowledge about the structure of the human body. One of such advanced imaging systems is a 3D atlas of human anatomy, 3D Organon VR Anatomy, an interactive anatomical atlas demonstrating all systems of the human body. This technology is active applied in the training course at the Department of Human Anatomy of the Poltava State Medical University. Among the advantages of the interactive table is the ability to use it when conducting classes in remote mode (online) that was especially relevant during the COVID-19 pandemic and in martial law in Ukraine. An anatomical table shows a human body model thus allowing students to visualize and study all structures, from bones to organs, change their position in 3D format at different magnification, and arrange them in a transverse position (to assess the anatomical shape and the relative location of organs inside the human body)..

The multimedia complex "Oniko" is widely applied for learning and teaching normal and topographic anatomy. The complex is also suitable for making familiar with several medical branches, including surgery, dentistry, ophthalmology, forensic medical examination, and others. The complex promotes interdepartmental integration of the educational process at the university. Working with highly realistic models gives students valuable experience.

The integrated use of new computer technologies, imaging systems, and traditional methods will enables provided more in-depth study of anatomy and significantly increase educational proficiency of future doctors.

The interactive anatomical systems are the most technologically advanced anatomical imaging system in medical education designed to educate the medical community that improve the effectiveness of teaching medical disciplines and promote the image of the institution in the educational and medical environment.
PROSPECTS OF THE INTEGRATION OF THE UKRAINIAN HIGHER EDUCATIONAL SYSTEM INTO THE EUROPEAN EDUCATIONAL SPACE
Authors: Kovalenko N.P. , Bobrova N.O. , Pospielova G.D. , Fedorchenko V.I. , Gancho O.V.
Published: March 2023

Introduction: In today's society, the challenges brought about by the COVID-19 pandemic and Russia's armed aggression against Ukraine in 2022 have heightened the need for global changes in higher education. The integration of national education systems into a single global educational space, with corresponding unification and renewal, has become necessary to meet the demands of the times. As a result, a significant transformation of learning approaches and the transition to various distance platforms have become essential. Even in the challenging conditions of the Russian-Ukrainian war, higher education has demonstrated its viability and readiness to adapt to contribute to progressive societal transformations, based on information, knowledge, and scientific achievements. Goal: The purpose of this study is to identify the prospects for integrating Ukraine's higher education system into the European educational space and the challenges associated with the integration process. Material: The Bologna process harmonizes higher education systems of participating countries, forming a single European market of higher education and highly qualified labour. The integration of Ukraine into the European educational space strengthens our position on the world market of educational services and solves the problem of recognition of Ukrainian diplomas. It will enable domestic universities and specialists to achieve an equal position in the European and world community. The development of education and science must meet the needs of society because high-quality education and science can solve problems related to medicine and digitalization, high-tech industries, energy-saving technologies, ensuring the rule of law, etc. Conclusions: The development of education and science must meet the needs of society because without high-quality education and science, it is impossible to solve problems related to the development of medicine and digitalization, high-tech industries, energy-saving technologies, ensuring the rule of law, etc. The activation of European integration processes in the sphere of higher education in Ukraine is possible by increasing the role of the state and university management in creating optimal conditions and incentives for international cooperation. The state should improve the financial support of higher educational institutions and promote their international cooperation. It is also important to update the list of specialities based on modern needs of the domestic and international labour market. Higher educational institutions should implement the latest models of educational process organization and learning technology, provide training for teachers and students on European integration and participation in European educational programs, and promote the practice of teaching subjects in a foreign language.
THE SIGNIFICANCE OF THE CHEMICAL COMPONENT "MEDICAL CHEMISTRY" IN THE PROFESSIONAL TRAINING OF THE FUTURE DOCTOR
Authors: Kuznetsova T.Y. , Stryzhak D.O. , Kryvoruchko A.V. , Stryzhak S.V. , Kulenko O.A.
Published: March 2023

Reforming the health care system is an integral part of our country's socio-economic transformations. Orientation towards new forms of health care provision involves improving the system of future doctors training by approaching it to international educational standards. In the system of professional doctor’s training, the study of chemical disciplines is an inseparable part of the educational process, because basic knowledge is the foundation for a number of the clinically essential disciplines. Therefore, the purpose of the article was to reveal the peculiarities of the formation of professional competences of future doctors in the process of studying the discipline "Medical Chemistry". In accordance with the requirements of the curriculum "Medicine" of the second (master's) level of higher education in the specialty 222 "Medicine", the field of knowledge 22 "Healthcare" The educational discipline "Medical chemistry" is studied over the first semester of the first year of study. The discipline covers the chemical bases of the processes of life of a living organism, which are ruled by the main chemical patterns. Medical chemistry also focuses on the structure and reactivity of the most important biologically active molecules, the theory of chemical bonding in complex compounds of biometals and bioligans, and the role of biogenic elements in the body functions. The discipline explains the processes that occur at the molecular and submolecular levels, as causes of various forms of diseases and the specificity of hereditary signs originate at those levels. The chemical component "Medical Chemistry" is based on the study of bioorganic chemistry students, medical and biological physics, medical biology and integrated with these disciplines; it makes the ground for deeper understanding of physiology, pathophysiology, biological chemistry, pharmacology and toxicology, hygienic disciplines and ecology. Thus, the discipline "Medical Chemistry" is an adapted version of the classical model of a chemical course that contains separate sections of general, inorganic, analytical, physical, and colloidal chemistry. Its primary goal is to equip future highly qualified doctors with theoretical knowledge and practical skills important for their professional development
MULTIMEDIA SYSTEMS IN TEACHING AND LEARNING AT THE DEPARTMENT OF HISTOLOGY, CYTOLOGY AND EMBRYOLOGY
Authors: Lysachenko O.D. , Shepitko V.I. , Boruta N.V. , Pelypenko L.B. , Vilkhova O.V.
Published: March 2023

Modern computer technologies are aimed at improving the quality of educational process, efficiency of providing educational information, structuring and systematization of theoretical and practical knowledge, enhancing students’ skills. Histology, cytology, and embryology are fundamental disciplines based on the deep understanding of structural organization of cells, tissues, and organs. A comprehensive innovative approach to teaching the discipline consists in using multimedia resources to support lectures and practical classes via the visualization of tissue and cellular structures on electron microscopic, light-optical and molecular levels; via the demonstration of microscopic preparations using video systems; by performing formative and summative assessment of knowledge through computer testing.

The latest learning technologies are multimodal including graphic and audiovisual means that contributes to the better involvement of all organs of perception, thus making difference to the routine educational process in general. The digital database of histological preparations of the different magnification under the microscope, which can be used during lectures, at every practical session and during self-training, is very popular among students.

Multimedia systems are aimed at improving teaching methods, improving the quality of delivering knowledge, fostering the personality, broadening students’ outlook and developing their intelligence. Multimedia systems include the support for lectures, practical classes and self-directed extracurricular work when preparing for classes, module test, and mastering practical skills.
THE IMPACT OF WORKING CONDITIONS ON THE OCCURRENCE OF CONJUNCTIVAL AND CORNEAL DISEASES IN MODERN OIL INDUSTRY
Authors: Ibragimova S. N.
Published: March 2023

The problem of the development of eye diseases in people employed in hazardous industries, including the oil industry, remains relevant in Azerbaijan, as the health protection of the working population is a priority. This paper presents the results of a study on the impact of the severity of working conditions in the modern oil industry of Azerbaijan on the occurrence of conjunctival and cornea diseases. The objective of the study is to assess the working environment at the enterprises of oil and gas production profile of the State Oil Company of the Azerbaijan Republic (SOCAR) in terms of their impact on the occurrence of eye diseases. In total, 1852 employees from 13 SOCAR enterprises, who are willing to voluntarily participate in the study, were selected by random systematic sampling. The research was conducted in 2018-2019. According to the obtained data, 55.5% of workplaces in the enterprises belong to class A (optimal working conditions). However, in such industries as “Oil Rocks” and “Siyazan Oil”, on average, 30% of workplaces belong to a high hazard class C. Conjunctival and corneal pathologies were detected in 33% of all workers during the study. There was a statistically significant difference in the character of the conjunctival and corneal diseases, depending on the severity of working conditions. The percentage of occurrence of dry eye syndrome was significant in all conditions of labour severity and ranged from 65 to 79%. The majority of participants employed in the production group of “Class C – heavy working conditions” had a high incidence of conjunctivitis of various aetiologies (18%). To reduce the occurrence of conjunctival and corneal diseases, it is recommended to adhere to preventive measures for employees working in difficult working environment.
PEDAGOGICAL CREATIVITY OF EDUCATORS UNDER THE CONDITIONS OF INNOVATIVE DEVELOPMENT OF MODERN EDUCATION
Authors: Nіemtchenko І.І. , Liakhovskyi V.І. , Lisenko R.B. , Liulka O.N. , Krasnov O. G. , Ryabushko R.M. , Horodova-Andryeyeva T.V.
Published: March 2023

A feature of modern education is innovativeness - the ability to update.

Therefore, improving the quality of modern education is impossible without the creation of an innovative space, that is, the study and active implementation of innovative pedagogical technologies in practice, the main task of which is to ensure a new quality of education, which involves improving learning, education and personality development. Innovative in terms of content and nature, the dynamics of world trends require the modern teacher to mobilize creative potential in order to provide quality educational services and train a highly qualified competitive specialist in the modern labour market. In order to achieve effective transfer of knowledge and formation of competences, the teacher must show creative initiative when choosing modern forms and methods of work of innovative orientation, using certain criteria that allow judging the effectiveness of this or that innovation, creating an appropriate atmosphere of creative, searching, innovative activity. Therefore, the teacher's creative activity becomes the main direction of the implementation of modernization reforms in education and one of the essential directions of the transition to the model of innovative development. The use of modern information technologies has a qualitative effect on the professional activity of the teacher, as a result of which he acts as an intellectual, an organizer of the educational process and a translator of the necessary knowledge, skills and abilities. The introduction of modern pedagogical technologies into the educational process requires the teacher to have serious preparation and confident mastery of the material, a clear understanding of how to perform this task, prompts him to show creative initiative, creating a basis for the full-fledged development of a creative personality, thus contributing to the acquisition of advanced pedagogical experience for quality preparation of students for future professional activities.
SIMULATION LEARNING AND CASE TECHNOLOGIES IN FUTURE DOCTORS’ TRAINING
Authors: Sukhonosov R.O. , Tereshchenko A.O. , Lopushniak L.Ya. , Honcharenko V.A. , Harkusha M.A.
Published: March 2023

At the current stage of healthcare provision, more and more attention is being paid to patient safety, ethical questions, increasing demand to responsibility of healthcare professionals, their professional aptitude, as well as rapid evolution of different procedures and methods. Virtual reality tools are seen as a source of technological opportunities in the education and medicine, complementing a set of traditional learning methods. Building up and fostering professional competences over the discipline «Human Anatomy» implies appropriate using the latest technologies that contribute to the development of clinical thinking and knowledge acquisition. The aim of this study is to conduct a theoretical analysis of scientific psychological, pedagogical, methodological and medical publications, methodological work of the department on applying modern pedagogical technologies in the process of professional training of future medical doctors.

The use of the latest methods and modern computer technologies in the teaching medical students leads to better educational outcomes, stronger professional competencies as well as promotes the development of clinical thinking that allows future doctors to generate interesting ideas, make the right and quick decisions and be active learners. The combination of classical anatomy and the cutting edge innovative computer technologies provides an excellent opportunity to dive into the extraordinary fascinating world of the human body. The use of modern pedagogical technologies, and, in particular, simulation learning technologies and case technologies in the course of doctors’ training performs several important functions: controlling, as it reveals the assimilation of knowledge, build up of skills and abilities; educational, as it ensures that students achieve a high level of knowledge in the discipline; educational, as it fosters the personal qualities of future doctors. Effectively organized student's independent learning and classroom activities enable teacher to promote the development of clinical thinking, which makes the ground for the formation of qualified and successful specialists.
BUILDING AND MAINTAINING COGNITIVE INTEREST AND MOTIVATION FOR LEARNING AS MEANS OF IMPROVING THE QUALITY OF DENTAL DOCTORS’ TRAINING
Authors: Yatsenko I.V. , Ivanytska O.S. , Lokes K.P. , Havryliev V.M.
Published: March 2023

One of the most important factors in increasing the efficiency of the modern educational process is maintaining students' constant interest in acquiring new knowledge and skills. According to the authors, among the variety of methods and techniques contributing to fostering permanent cognitive interest in mastering the future profession over the courses of clinical disciplines, the familiarity with the life path of outstanding scientists and talented doctors of the past can be successfully used. The aim of this paper is to improve the method of teaching the topic "Permanent immobilization in case of damages to the bones of the facial skull" that is learnt during the study of Module 4 "Traumatology of the maxillofacial area". Materials and methods. A literature search and analysis of publications on the specified issues was conducted by using library sources and search engines. Results. When studying the topic "Permanent immobilization in case of damages to the bones of the facial skull" in the course of surgical dentistry, it is worth emphasizing that before the beginning of the First World War (1914-1918), doctors tried to find an optimal solution in fixing and treating cleft fractures. Severyn Tigerstedt, one of the dentists of the Kyiv Military Hospital, offered the best option for that time. The doctor suggested using bent wire dental splints for fractures of the lower jaw. His idea turned out to be simple, but extremely effective. Over a hundred years, his revolutionary invention has been successfully used by maxillofacial surgeons for the orthopaedic treatment of fractures of the lower jaw. The analysis of our experience of introducing interesting facts about the life and scientific achievements of the most notable figures in maxillofacial surgery allows us to argue that this approach seems as very helpful in provoking the interest of students, maintaining their constant attention and contributing to the development a harmonious personality.
MAIN TRENDS IN RESEARCH OF TEMPOROMANDIBULAR JOINT PATHOLOGY IN UKRAINE
Authors: Zhehulovych Z.Y. , Etnis L.O. , Sayapina L.M.
Published: March 2023

The multifactorial concept of the origin of temporomandibular disorders implies a multidisciplinary approach to the diagnosis, treatment, and prevention of this pathology. The aim of the work was to determine the main trends in the study of diagnosis and treatment of temporomandibular joint diseases in Ukraine. A content analysis of the results of scientific research in professional publications of Ukraine by specialty code 221 “Dentistry” for the period from 2017 to 2021 years on the etiology, pathogenesis, diagnosis, and treatment of temporomandibular joint diseases was carried out. During the state period, 55 scientific sources were identified and analyzed in accordance with the purpose of the research in 13 publications (9 literature reviews and 46 articles with the results of the author’s research). All publications by specialty were distributed as follows: orthopedic stomatology – 34 sources (61,8 %), orthodontics – 6 (10,9 %), surgical stomatology – 8 (14,6 %) and team research – 7 (12,7 %). According to the results of the analysis of the thematic materials in the professional journals of Ukraine, studies devoted to the development of a complex and interdisciplinary approach to the diagnosis and treatment of temporomandibular disorders prevail. The conducted content analysis of the results of scientific research determined that despite the active implementation of the latest technologies for the diagnosis and treatment of temporomandibular disorders, a number of issues in this field remain unsolved and require revision in the dental community and doctors of related specialties. Among the debatable issues is the use of questionnaires and classifications of temporomandibular joint diseases. In order to promote a broad discussion and exchange of scientific achievement, it is urgent, according to the researchers, to study the world experience of creating and using unified questionnaires, diagnostic protocols, and classifications of temporomandibular joint diseases. Also, research results need to be systematized and generalized to create practical recommendations for improving teamwork among doctors of various specialties and patient motivation.
USE OF CUSTOM ABUTMENTS IN PROSTHETIC TREATMENT WITH IMPLANT-SUPPORTED RESTORATIONS
Authors: Marchenko K.V.
Published: March 2023

Today, implantation surgery allows for a predictable result in the rehabilitation of patients with partial or complete absence of teeth. Modern technological capabilities allow dentists and dental technicians to use numerous approaches to the choice of materials, ways of manufacturing individual abutments and their final design. However, there is no definitive protocol for the selection of all components of the structure. The purpose of this study was to review the literature on the mechanical and aesthetic results of using customized implant abutments in the replacement of dentition defects with implant-supported prosthetic structures. A literature search was conducted using the PubMed electronic database using the search term "custom abutment". The search period covered the period from January 2012 to December 2022. The final review included 32 articles. The review of current scientific sources provided preliminary evidence that in most cases, the use of customized implant abutments makes it possible to perform predictable restoration of function in patients with missing teeth. At the same time, dentists have a wide range of materials in their arsenal to achieve highly aesthetic results without significant compromise in mechanical performance compared to classic titanium abutments. Further modernization of approaches to the standardization of the manufacture of individual abutments is likely to lead to the everyday use of such structures not only in areas of the oral cavity where the requirements for aesthetics are increased to the maximum, but also to their use in other situations.
COMPARATIVE ANALYSIS OF THE PREVALENCE OF NORMOTENSION AND HYPERTENSION IN DIAGNOSIS OF ARTERIAL HYPERTENSION ACCORDING TO ESC/ESH (2018) AND ACC/AHA (2017) DIAGNOSIS IN PEOPLE WITH NORMAL GLUCOSE METABOLISM, PREDIABETES AND TYPE 2 DIABETES
Authors: Isgandar M. A. , Gurbanov Y. Z. , Huseynova N. N. , Sultanova S. S. , Mirzazade V. A.
Published: March 2023

The comorbidity between hypertension with diabetes leads to an increase in the risk of death and cardiovascular events by 44% and 41%, respectively, compared with 7% and 9% risks in people suffering only from diabetes and having no hypertension. Purpose. To determine the effect of the criteria for the diagnosis of hypertension proposed by ACC/AHA (2017) and ESC/ESH (2018) on the detection of this disease in people with normal carbohydrate metabolism, prediabetes and type 2 diabetes mellitus. Materials and methods. A retrospective analysis of the database of the Azerbaijan Association of Endocrinology, Diabetology and Therapeutic Training was carried out. The data of 596 examined patients were analyzed, then three main groups were formed: a group with normal carbohydrate metabolism (n=99), a group with prediabetes (n=47), a group with type 2 diabetes mellitus (n = 450). The patients included in the study were divided into 2 samples: those, who have DM2; those, who have no DM2. Including the patients in the group of with DM2 was based medical history data about the presence of DM2 and / or taking hypoglycemic drugs. Results. When applying the ACC/AHA criteria (2017), normotension (systolic blood pressure <130 mmHg and diastolic blood pressure <80 mmHg) occurred in 40.4% (95% CI 30.69%; 50.12) of the control group, while 59.6% (95% CI 49.88; 69.31) there was arterial hypertension. 14.9% of the prediabetes group (95% CI 4.60%; 25.18)% had normotension according to the same criteria, while the majority of the participants in this group – 85.1 (95% CI 74.82; 95.40)% had arterial hypertension. In the type 2 diabetes mellitus group, normotension was found in 15.8 (95% CI 12.41%; 19.15)%, and arterial hypertension – in 84.2 (95% CI 80.85; 87.59)%. Thus, arterial hypertension was statistically significantly less common in the control group than in prediabetes (p <0.01) and type 2 diabetes mellitus (p <0.001). Conclusion. Thus, in people with normal carbohydrate metabolism, prediabetes and type 2 diabetes mellitus, the use of ACC/AHA diagnostic criteria (2017) led to a statistically significantly higher incidence of hypertension than when using the criteria for the diagnosis of hypertension according to ESC/ESH (2018).
UNICOMPARMENTAL KNEE REPLACEMENT VS TOTAL: INDICATIONS AND CONTRAINDICATIONS
Authors: Linko Y.V. , Rokyta T.G. , Rokyta V.G.
Published: March 2023

Introduction. Unicompartmental knee arthroplasty (UKA) has become increasingly popular in the treatment of a number of knee joint diseases, especially in the last few years. The purpose of the study is to evaluate the results of UKA, to evaluate the indications and contraindications for OEC of the knee joint. Research materials and methods. The study included 128 patients with a diagnosis of gonarthrosis, aged from 40 to 79 years (average age 63.2 ±5.4 years). Of these, 56 patients underwent UKA, and 72 underwent total arthroplasty. Results. It has been established that there are significant differences in the results of knee arthroplasty. On average, these differences are revealed after 7 years, as shown by the assessment on the visual analog scale VAS, as well as the scales WOMAC, KKS, IKDC. It has been found that there is less pain during high-intensity exercise for patients with UKA, such activities include climbing or descending stairs, as well as moving over long distances. on average, the duration of gonarthrosis among patients with total arthroplasty was 2.5 times longer, while among patients with UKA, those with the second stage of the disease were 4 times more frequent. Patients with total arthroplasty more often had a mixed contracture, while patients with UKA more often had a flexion or extensor contracture. Among patients with UKA, a more dynamic gait was noted, they did not use crutches, but 60% of them used a stick. Analysis of long-term outcomes also showed significant differences in favor of patients with OEC. In particular, the Knee Society score scale showed a tendency to increase from 57 (in the range of 42-94 points) points before surgical intervention to 89 (62-98) points after. An increase in functional indicators was also noted from 60 before the operation (46-95) to 89 (56-99) after. Oxford scale scores also increased, from 26 (13-40) before surgery to 41 (29-55) after it. Before surgery, range of motion indicators were 130° (within 121°-136°), while after surgery they were 136° (119°-143°). Conclusions. UKA takes more and more place in the treatment of knee arthrosis. This is explained by the greater "physiological" nature of the operation as it does not change the biomechanics of the knee, the expansion of indications for it, the development of new technologies and modern materials, and a considerable percentage of "dissatisfaction" after total knee arthroplasty.
ASSOCIATIONS BETWEEN STRUCTURAL AND FUNCTIONAL STATUS OF MYOCARDIUM AND SERUM LEVELS OF NT-proBNP AND ST2 IN PATIENTS WITH COMBINED CARDIAC PATHOLOGY
Authors: Ivanov V. P. , Zakrevska M. M.
Published: March 2023

Damage to the heart under essential hypertension manifests a combination of changes in the left ventricle, left atrium, and coronary arteries resulted from a chronic elevation in blood pressure. Hypertension increases the load on the heart, causing structural and functional changes in the myocardium. Associations between clinical, laboratory and instrumental indicators and the levels of various biomarkers, which characterize the specificity and severity of systemic processes occurring in the cardiovascular system and can also be used for predicting the prognosis of diseases, are of undoubted practical interest.

The aim of this study was to research the associations between the structural and functional state of the myocardium and the levels of serum NT-proBNP and ST2 in hypertensive patients with / without chronic coronary disease.

Materials and methods. 118 patients with stage II hypertension with / without chronic coronary disease were included in the study. For all patients, both the main indicators of the structural and functional state of the myocardium according to echocardiography and serum levels of NT-proBNP and ST2 were additionally measured on the 2-3rd day of hospital stay when optimal therapy was being selected.

Results. The obtained data indicate that a relatively low level of NT-proBNP is associated with a significant increase in the size of the right atrium and the right atrial index and the frequency of cases with concentric hypertrophy of the left ventricle compared to intermediate and relatively high levels of the neurohormone. The patients with relatively low neurohormone level demonstrate a significant increase in end-diastolic size and left atrial size compared with only intermediate levels. The results of the analysis of changes in echocardiogram indicators depending on the level of ST2 in plasma demonstrate the complete absence of any reliable changes between the selected groups.
HORMONAL CHANGES ASSOCIATED WITH PELVIC ORGAN PROLAPSE
Authors: Kamilova N.M. , Abbasova R.K. , Kafarov I.Н.
Published: March 2023

Goal. To determine the characteristics of the level of sex hormones in the blood plasma in women with genital prolapse urinary incontinence. Material and methods. The study was conducted on the basis of the Surgical Training Building of the Azerbaijan Medical University from December 2017 to May 2021. Questionnaires for socio-demographic/clinical data PFDI-20 and PFIQ-7 to detect genital prolapse and urinary incontinence were applied to 144 patients of reproductive age. All patients were divided into three groups: I a - main group, prospective analysis of 50 women aged 25 to 50 years with prolapse of the anterior vaginal wall and urinary incontinence; I b is the main group, which will include women with relapses after surgical interventions for this pathology in the amount of 59 (retrospective material); II - comparative group: practically healthy women without genital prolapse and urinary incontinence, who had a history of 3 or more births (35 women). A hormonal background study was conducted in 50 women with signs of PG (the main group) aged 25 to 50 years (average age -39.7 ± 7.3 years). The levels of testosterone, estradiol, progesterone, Anti-Muller hormone and cortisol in the blood serum were determined. Determination of the level of hormones in blood plasma was carried out on the immunoanalyzer Miсroplate reader RD-2100C (PRC). Results. It was found that the level of estradiol in the examined women varied between 31.1 – 84.6 nmol/L. In 13 patients of the main Ia group, the level of estradiol varied from 31.3 to 44.8 nmol/L. In 14 patients, estradiol was in the range of 47.3 – 53.8 nmol/L, in 16 patients the estradiol level varied between 57.6 – 64.6 nmol/L, in 4 patients the estradiol index was in the range of 65.8 – 71.0 nmol/L and in 3 patients in the range of 76.3 – 84.6 nmol/L. Conclusions. The average levels of estradiol, progesterone and testosterone in patients of reproductive age with genital prolapse and urinary incontinence did not differ significantly. The Anti-Muller hormone index differs in patients with genital prolapse and urinary incontinence from compared with the control (U =613.0, p≤0.001). The quantitative value of Anti-Muller hormone is significantly reduced and is within the range that is typical for women during menopause. The cortisol index is statistically significantly different in patients with genital prolapse and urinary incontinence from healthy women.(U =690,0, p≤0,001)
MODERN POSSIBILITIES OF ULTRASOUND SCAN IN DIAGNOSIS OF MORTON'S NEUROMA
Authors: Dudnyk T.A. , Pochernjeva V.F. , Vasko L.N.
Published: March 2023

About 60% of healthy people at least once in their lives complained of pain in the anterior foot that was diagnosed as Morton's neuroma. According to numerous resources, ultrasound scan is one of the leading methods for diagnosing the condition of the soft tissues in the foot, thus, this diagnostic technique can be considerably helpful in determining the nature and extent of the pathological condition and making the decision about the necessity of surgical treatment. Aim: to assess the potential of ultrasound investigation and to systematize the ultrasound criteria for Morton's neuroma using a two-dimensional mode, colour and energy mapping, and functional ultrasonography. Material and methods. We analyzed the findings obtained by the ultrasound scan of soft tissues in the foot of 26 people who complained of pain in the projection of 3-4 metatarsophalangeal joints. The following echographic data were evaluated: homogeneity, echogenicity, integrity of the soft tissues of the intermetatarsal spaces and tendons of the fingers, the presence of effusion in the articular capsules and tendon sheaths, the number of vascular signals in the affected area during power Doppler mapping. Results and discussion. In the control group of patients, the analysis of ultrasound has revealed the following echographic features: the contour of the cortical layer of the metatarsal bones is represented by a hyperechoic line with a clear acoustic shadow along it in all cases (100%); flexor tendons of the toes are located above the surfaces of the bones (100%); no masses are found in the intermetatarsal spaces in 100% of cases; the width of the intermetatarsal spaces is 5.0–9.0 mm in all cases (100%). In the main group of patients, the analysis of ultrasound findings has revealed the following structural changes: the contour of the cortical layer of the metatarsal bones is represented by a hyperechoic circular line with a clear acoustic shadow along it in 8 cases (30.7%); in 18 cases (69.3%) the contour of the cortical layer is uneven with a fuzzy acoustic shadow; flexor tendons of the toes are of reduced echogenicity and have heterogeneous structure in 16 cases (61.5%); space-occupying formations have been found in the intermetatarsal spaces of the III-IV toes in 24 cases (92.3%), and in the intermetatarsal spaces of the II-III toes and in 2 cases (7.7%); the width of the intermetatarsal spaces at the location of the mass formation in all cases (100%) is 10.0-15.0 mm. Conclusion. At the present, the access to ultrasound, its non-invasiveness, the absence of ionizing radiation, the possibility of dynamic observation, and relatively high accuracy in assessing the tibial nerve put it at the forefront in the diagnostic algorithm for detecting Morton's neuroma.