Hubungan antara Resistensi Insulin dan Kadar Hepsidin (Regulator Zat Besi) Terhadap Fenotipe Sindrom Ovarium Polikistik (SOPK)
Authors:   Departemen Obstetri dan Ginekologi, Fakultas Kedokteran Universitas Hasanuddin, Putra Brilian Segala , Abdullah Nusratuddin , Madya Fatmawaty , Asni St. Nur , Tahir Andi Mardiah , Lisal Lenny 
Published: March 2023

Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan antara Resistensi Insulin dan kadar hepsidin serum terhadap fenotipe Sindrom Ovarium Polikistik (SOPK). Resistensi insulin dan hiperinsulinisme yang terjadi pada SOPK dapat meningkatkan eritropoiesis, yang dapat menyebabkan penurunan regulasi ekspresi hepsidin Metode: Penelitian ini menggunakan metode cross sectional dan dilakukan di beberapa rumah sakit pendidikan di Makassar, Indonesia. Kami memasukkan pasien yang didiagnosis dengan sindrom ovarium polikistik (SOPK) berusia 18-40 tahun. Resistensi Insulin diperiksa mengunakan metode HOMA-IR dan kadar hepsidin diperiksa menggunakan metode enzyme-linked immunosorbent assay (ELISA) pada semua subjek yang memenuhi syarat. Hasil yang diperoleh selanjutnya dianalisis secara statistik. Hasil: Sebanyak 52 pasien SOPK dilibatkan dalam penelitian ini, 40 pasien dengan resistensi insulin dan 12 pasien tanpa resistensi insulin. Setelah memeriksa kadar hepsidin serum, kami tidak menemukan perbedaan resistensi insulin diantara keempat fenotipe SOPK (p>0,05), namun terdapat perbedaan kadar hepsidin SOPK fenotipe A dengan fenotipe C (p<0,05). Kami juga menemukan korelasi negatif sedang antara kadar hepsidin serum dengan homeostatic model assessment for insulin resistance (HOMA-IR) (r=-0,419; p<0,05). Kesimpulan : Terdapat hubungan yaitu semakin tinggi resistensi insulin, semakin rendah kadar hepsidin serum. Dan tidak terdapat perbedaan resistensi insulin pada SOPK diantara keempat fenotipe namun terdapat perbedaan kadar hepsidin serum yang lebih tinggi pada SOPK fenotipe A dibanding SOPK fenotipe C Correlation between Insulin Resistance and Hepcidin Levels (Iron Regulator) and Polycystic Ovarian Syndrome Phenotype Abstract Objective: The goal of this study was to know the relationship between Insulin Resistance and serum hepcidin levels on Polycystic Ovarian Syndrome (PCOS) phenotype. Insulin Resistance and hyperinsulinism in PCOS promote erythropoiesis which can result in downregulation of hepcidin expression Methods: This study uses a cross sectional and was conducted at several educational hospitals in Makassar, Indonesia. We included patients diagnosed with polycystic ovarian syndrome (PCOS) aged 18-40 years. Insulin resistance was checked using the HOMA-IR method and hepcidin levels were checked using the enzyme-linked immunosorbent assay (ELISA) method on all subjects meeting the requirement. The results obtained will then be analyzed statistically. Results: 52 PCOS patients are included in this study, 40 patients with insulin resistance and 12 ones without insulin resistance. After examining the serum hepcidin level, we did not find a difference in insulin resistance among the four PCOS phenotypes (p>0.05), however there is PCOS level difference of phenotype A and phenotype C (p<0.05). We observed as well medium negative correlation between serum hepcidin level and the homeostatic model assessment for insulin resistance (HOMA-IR) (r=-0.419; p<0.05). Conclusions: Correlation is found where the higher the insulin resistance, the lower the hepcidin serum level. Also no difference is observed in insulin resistance of PCOS among the four phenotypes, however serum hepcidin level difference is indicated higher on PCOS phenotype A compared to that of PCOS phenotype C. Key words: polycystic ovarian syndrome, hepcidin, insulin resistance