bluuebunny/crossref_metadata_2025 huggingface dataset:
Contributions of Municipal Initiatives to Digital Health Equity
Authors: Almeida Fernando
Published: November 2024

Sustainable initiatives play a crucial role in promoting digital health equity by addressing barriers to access and ensuring equitable use of digital health technologies and services. These initiatives may arise in various contexts, including local collaborative networks that emerge in the municipal context. This study aims to identify and characterize the municipal initiatives that have been developed in Portugal to promote digital health equity. It adopts a mixed methods approach to initially quantify the distribution of these projects in the Portuguese territory and, at a later stage, to understand the level of influence of these projects, considering their impact on individual, interpersonal, community, and societal levels. The findings identified 22 municipal sustainable initiatives and concluded that there is a strong relationship between the areas of community and individual influence. The results of this study are relevant to deepening the knowledge of bottom-up innovation in the digital health field and establishing public policies to increase the impact of these projects at the territorial level, the communities involved, and the social objectives addressed, contributing to greater social cohesion.
Embryology and classifications of spinal cord lipomas (literature review)
Authors:   Department of Neurology and Neurosurgery named after Yu. S. Martynov, Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN), State Budgetary Healthcare Institution of the City of Moscow Morozov ChildrenCity Clinical Hospital» of the Moscow Healthcare Department, Russia, Annanepesov N.S. , Gerald Musa Gerald ,   Department of Neurology and Neurosurgery named after Yu. S. Martynov, Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN), Moscow, Russia, Chmutin E. G. ,   Department of Neurology and Neurosurgery named after Yu. S. Martynov, Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN), Moscow, Russia, Kuznetsova A. A. ,   State Budgetary Healthcare Institution of the City of Moscow Morozov Children City Clinical Hospital of the Moscow Healthcare Department, Russia, Mwela Bupe M. ,   Department of Pediatrics, Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN), Moscow, Russia, Chmutin G. E. ,   Department of Neurology and Neurosurgery named after Yu. S. Martynov, Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN), State Budgetary Healthcare Institution of the City of Moscow Morozov Children City Clinical Hospital of the Moscow Healthcare Department, Russia
Published: November 2024

Lumbosacral lipomas are congenital spinal malformations caused by defects in primary and secondary neurulation during embryogenesis, leading to tethered spinal cord syndrome and neurological deficits. Understanding the embryological development and pathogenesis of these lipomas is crucial for improving surgical outcomes. Embryogenesis involves primary neurulation, where the neural plate forms and folds into the neural tube, and secondary neurulation, where the medullary cord forms and differentiates into the conus medullaris and filum terminale. Disruptions in these processes can result in lumbosacral lipomas. The premature disjunction theory suggests that early
ectoderm separation allows mesenchymal invasion, while dorsal induction disorders and secondary neurulation defects
involve mesodermal elements disrupting normal development, leading to lipomatous tissue tethering the spinal cord. The classification systems by Chapman, Arai, and Pang categorize lumbosacral lipomas based on anatomical and embryological features, aiding in surgical planning and prognosis. These classifications help neurosurgeons determine the complexity and associated risks of lipomas, guiding surgical techniques to minimize complications and improve outcomes. Understanding these classifications and the underlying embryology is essential for advancing treatment and patient care.
Results of applying a personalized approach in microsurgery of cerebral aneurysms using supraorbital mini-craniotomy
Authors:   Moscow Regional Clinical Research Institute named after M. F. Vladimirsky, Dzhindzhikhadze R. S. ,   Moscow, Polyakov A. V. ,   Moscow Regional Clinical Research Institute named after M. F. Vladimirsky; Moscow, Gadzhiagaev V. S. ,   Moscow Regional Clinical Research Institute named after M. F. Vladimirsky; Moscow, Sultanov R. A. ,   Moscow Regional Clinical Research Institute named after M. F. Vladimirsky; Moscow, Zaytsev A. D. ,   Moscow Regional Clinical Research Institute named after M. F. Vladimirsky; Moscow, Derkach M. I. ,   Moscow Regional Clinical Research Institute named after M. F. Vladimirsky; Moscow, Strakhov G. Yu. ,   I.M. Sechenov First Moscow State Medical University, Kasymov M. U. ,   Tula City Clinical Emergency Hospital named after D. Ya. Vanykin,, Danilov G. V. ,   National Medical Research Center of Neurosurgery named after N.N. Burdenko
Published: November 2024

The purpose was to evaluate the results of applying supraorbital mini-craniotomy in the microsurgical
treatment of cerebral aneurysms using a personalized approach, and compare the safety and efficacy
of supraorbital mini-craniotomy with traditional pterional approach by means of the pseudo-randomization
method. Materials and Methods. We conducted an analysis of the microsurgery results in 455 patients with
cerebral aneurysms over the period from 2014 to 2023. The study included patients operated on using traditional pterional craniotomy (n=200, 43.9 %) and supraorbital mini-craniotomy (n=255, 56.04 %). We compared treatment outcomes in patients during the acute phase of rupture and in cases of unruptured aneurysms (UA).
The safety and efficacy of the microsurgical treatment were assessed through the analysis of functional outcomes, aneurysm exclusion completeness, and perioperative complications. Additionally, the duration of the surgery and postoperative hospital stay were evaluated. Follow-up was conducted over a period ranging from 12 to 48 months. Results. Comparative analysis using the pseudo-randomization method in the acute period of subarachnoid hemorrhage (SAH) confirmed that the duration of surgery and postoperative hospital stay were comparable. In cases of UA, the duration of surgery and postoperative hospital stay were significantly shorter in the supraorbital mini-craniotomy group (p<0.002 and p=0.032, respectively). The completeness of aneurysm exclusion and functional outcomes were comparable in both groups (p>0.05). There was no statistically significant
difference in the intra- and postoperative complications rates (p>0.05). Mortality rates were comparable
in both groups. Conclusion. When using a personalized approach, supraorbital mini-craniotomy has safety and efficacy equivalent to traditional approach in the microsurgical treatment of cerebral aneurysms.
Current methods of diagnosis and treatment of neuropsychiatric disorders in systemic lupus erythematosus
Authors:   Department of Neurology, Psychiatry and Rehabilitation, NJSC Medical University of Karaganda, Karaganda, Republic of Kazakhstan, Pernebay A. N. , Orynbaeva A. M. ,   Department of Neurology, Psychiatry and Rehabilitation, NJSC Medical University of Karaganda, Karaganda, Republic of Kazakhstan, Makhmutova B. K. ,   Department of Neurology, Psychiatry and Rehabilitation, NJSC Medical University of Karaganda, Karaganda, Republic of Kazakhstan, Battakova Sh. B. ,   Department of Neurology, Psychiatry and Rehabilitation, NJSC Medical University of Karaganda, Karaganda, Republic of Kazakhstan, Otarbaeva M. B. ,   Department of Neurology, Psychiatry and Rehabilitation, NJSC Medical University of Karaganda, Karaganda, Republic of Kazakhstan, Grigolashvili M. A. ,   Department of Neurology, Psychiatry and Rehabilitation, NJSC Medical University of Karaganda, Karaganda, Republic of Kazakhstan
Published: November 2024

Neuropsychiatric systemic lupus erythematosus (NPSLE) is a severe complication of systemic lupus erythematosus (SLE), characterized by damage to the nervous system. The article discusses the pathogenesis, clinical manifestations, laboratory and instrumental diagnostics, as well as modern and promising methods of treating NPSLE. Both immunoinflammatory
(autoantibodies, cytokines) and ischemic (thrombosis, vasculitis) mechanisms are involved in the NPSLE pathogenesis. The clinical picture is varied and includes cognitive impairment, headache, seizures, psychosis, and other neurological and psychiatric symptoms. Diagnosis of NPSLE is difficult due to the lack of specific biomarkers. Both systemic markers (antibodies to dsDNA, Sm, SSA/Ro, SSB/La, aPL, anti-P, complement components) and nervous system-specific markers (antibodies to NR2, U1RNP, GAPDH, S100B, NfL, cytokines in CSF) are used. Instrumental diagnostics incorporates MRI, fMRI, MRS,
DTI, PET, and SPECT. Treatment of NPSLE includes glucocorticoids, immunosuppressants, anticoagulants, and symptomatic
therapy. Promising treatments include complement inhibitors, BBB repair therapies, MMPs inhibitors, IFN-α/β receptor antagonists, BTK inhibitors, S1P receptor modulators, ACE inhibitors, CSF1R inhibitors, and Nogo-A/NgR1 antagonists.
SAPHO syndrome, an orphan pathology in the practice of GPs and specialists. A clinical case
Authors:   RSBEI CPE Postgraduate Institute for Public Health Workers of the Ministry of Health of the Khabarovsk Region, Khabarovsk, Shirokova A. S. , Zakharycheva T. A. ,   FSBEI HE Far Eastern State Medical University of the Ministry of Health of the Russian Federation, Khabarovsk, Isaenko L. P. ,   RSBHI Viveya Consultative and Diagnostic Center of the Ministry of Health of the Khabarovsk Region, Khabarovsk, Aktanko S. A. ,   MRI Leader Magnetic Resonance Imaging Center, Khabarovsk
Published: November 2024

The article presents a case of SAPHO syndrome, a rare disease of connective tissue and the musculoskeletal system, as well as the results of dynamic observation of the patient. The COVID-associated disease debuted at the end of the second decade of life and manifested itself as a combination of skin and osteoarticular symptoms. Timely diagnosisof the pathological condition and early initiation of nonspecific treatment contributed to the stabilization of the patient’s condition and regression of the clinical manifestations of the disease.
Intraoperative diagnostics for cerebral aneurysm microsurgery in a hybrid operating room
Authors:   Pavlov First Saint Petersburg State Medical University, Burmakina M. D. , Cherebillo V. Yu. ,   Pavlov First Saint Petersburg State Medical University, Sergeev A. V. ,   Pavlov First Saint Petersburg State Medical University, Kachanov B. A. ,   Pavlov First Saint Petersburg State Medical University
Published: November 2024

Intraoperative diagnostics in microsurgery for cerebral aneurysms allows for timely identification
and prevention of potential complications. Commonly accepted intraoperative diagnostic methods, such as indocyanine green videoangiography and microvascular doppler ultrasound, are minimally invasive techniques
routinely used in aneurysm surgery. CTA and cerebral angiography, which can be applied intraoperatively in a hybrid operating room, are used less frequently and require further study. Purpose. То study intraoperative cerebral angiography and CTA in a hybrid operating room during microsurgery for cerebral aneurysms. Materials and methods. Surgical treatment was performed in a hybrid operating room. The hybrid operating room
is equipped with a radiolucent operating table, a robotic angiographic system that allows for a transition to the endovascular surgery stage without compromising sterility, and an intelligent positioning system for the robotic C-arm. The hybrid operating room equipment makes it possible to perform two-dimensional CAG, 3D angiography, and flat-detector CT angiography intraoperatively. During the reporting period, there were 23 microsurgeries for intracranial aneurysms in the hybrid operating room. Results. According to the results of intraoperative flat-detector CT angiography, the position of the clips was satisfactory in 15 patients after microsurgical
clipping of cerebral aneurysms. In these cases, radical exclusion of the aneurysm from the bloodstream
and the absence of functionally significant stenoses of the aneurysm-carrying arteries and adjacent perforating
vessels were diagnosed. In 2 patients (8.7 % of cases), incomplete clipping of the neck of the aneurysm was detected. Conclusions. CTA and cerebral angiography have greater diagnostic value compared to indocyanine green videoangiography and microvascular doppler ultrasound. The hybrid operating room allows for the use of CTA and cerebral angiography intraoperatively, which helps in identifying residual parts of aneurysms, stenoses, and occlusions of functionally important brain vessels at early stages and preventing acute ischemia and hemorrhagic complications.
КОМПАРАТИВНІ КОНСТРУКЦІЇ З ОРУДНИМ ВІДМІНКОМ У ТЕКСТАХ ТВОРІВ МАЙКА ЙОГАНСЕНА, ЮЛІАНА ШПОЛА ТА ГРИГОРІЯ ЕПІКА: ЛІНГВОКОГНІТИВНИЙ ПІДХІД
Authors: Половинко О. С.
Published: November 2024

У статті вперше проаналізовано порівняльні конструкції з орудним від-
мінком у текстах творів Майка Йогансена, Григорія Епіка та Юліана Шпо-
ла крізь призму когнітивно-ономасіологічного підходу. Розкрито характерні
ознаки мотиваційних типів. Визначено, що в усіх порівняльних конструк-
ціях образи підтягуються в компаративеми за принципами структурно-
метафоричного, дифузно-метафоричного та гештальтного мотиваційних
типів. Аналіз мови творів зазначених вище представників Розстріляного
Відродження виявив незначний масив концептосфер донорської бази порів-
няльних конструкцій з орудним відмінком, однак ці конструкції наділені особливостями в кожного з авторів.
РЕПРЕЗЕНТАЦІЯ КОНЦЕПТУ ГОЛОВА У ФРАЗЕОЛОГІЧНИХ ОДИНИЦЯХ УКРАЇНСЬКОЇ ТА АНГЛІЙСЬКОЇ МОВИ: КОМПАРАТИВНИЙ АНАЛІЗ
Authors: Koliada A.
Published: November 2024

Дослідження присвячено фразеологічним одиницям, що містять концепт ГОЛОВА, який відображає унівесальні когнітивні моделі, засновані на особливостях та історичного підґрунтя української та англійської мов. Наголошено на важливості аналізу концепту ГОЛОВА для розуміння розмаїття людської мови та когнітивного пізнання оточення людини. Вивчення зазначеного концепту ґрунтується на припущенні, що тіло людини вважається одним з перших об’єктів, доступних для спостереження та відіграє важливу роль у процесі отримання знань про події та явища, що відбуваються навколо людини, саме тому нерідко стає об’єктом для позначення різних сфер людської діяльності.
ХАРКІВСЬКИЙ ТЕРМІНОЛОГІЧНИЙ ОСЕРЕДОК: ДІЯЛЬНІСТЬ КЛЮЧОВИХ ПОСТАТЕЙ
Authors: Войтович О. О.
Published: November 2024

У статті аспектуально висвітлено діяльність ключових постатей хар-
ківського термінологічного осередку, що проєктується на період, який охоплює останню чверті ХХ – початок ХХІ ст. Окреслено основні напрями діяльності учених, ураховуючи й роботу над термінографічними словниками. Визначено основні тенденції поступу українського термінозавства, що презентовані в межах харківського осередку, зокрема це зацікавлення теоретичними питаннями національного термінознавства; прагнення популяризувати національний досвід; розроблення широкої системи лексикографічних напрацювань, що проєктуються на терміни технічних і гуманітарних наук.
СПОСОБИ ТВОРЕННЯ ТЕРМІНІВ НАНОТЕХНОЛОГІЙ
Authors: Кримець О. М.
Published: November 2024

У статті розглядаються шляхи виникнення спеціальних назв нано-
технологій – запозичення та морфологічне термінотворення. Досліджено
способи термінологічних запозичень – транслітерація, калькування, тран-
слітерація + калькування, а також морфологічний спосіб утворення спеці-
альних назв нанотехнологій – афіксація, що відбувається шляхом приєднання префіксів та суфіксів латинської, давньогрецької та української мови. Встанайпоширеніші значення префіксів та суфіксів, які застосовуютьсяь для творення термінів досліджуваної галузі
КОГНІТИВНИЙ ПІДХІД ДО ВИВЧЕННЯ СУЧАСНОЇ УКРАЇНСЬКОЇ ПОЛІЦІЙНОЇ ТЕРМІНОЛОГІЇ
Authors: Удовіченко Л. Г.
Published: November 2024

У статті наголошено на трансформаційних аспектах дослідницького
термінознавства, зумовлених розвитком вивчення мови в когнітивному
напрямі. Описано основні функції термінів, що зорієнтовано на когнітивне,
зокрема дискурсивне й концептуальне бачення галузевих термінологій. Ви-
світлено взаємодію і взаємопроникнення дотичних до поліційної терміно-
логійних систем, обґрунтовано особливості поданого процесу. На мовному
матеріалі продемонстровано польову структуру поліційної термінології
і вибудувані всередині неї міжгалузеві зв’язки. Визначено специфіку саме поліційних термінів з проєкцією на широкий спектр виконуваних професійних обов’язків.
ЕТАПИ ФОРМУВАННЯ ТЕРМІНОЛОГІЇ ВИДАВНИЧО-ПОЛІГРАФІЧНОЇ СПРАВИ (ХХ – поч. ХХІ ст.)
Authors: Черемська О. С. , Ходарєва І. М.
Published: November 2024

У роботі досліджено процес формування термінології видавничої справи
та поліграфії впродовж ХХ – поч. ХІ ст. Виокремлено основні етапи станов-
лення термінології як системи зазначеної галузі. Розглянуто спеціальні на-
зви, залучені з інших наукових та технічних галузей, що у сфері видавничої справи і поліграфії дістали нове термінологічне значення унаслідок зовнішньосистемної, міжсистемної та внутрішньосистемної полісемії. Схарактеризовано явище синонімії, поширене в українській видавничій термінології, основні способи термінотворення (лексико-семантичний, морфологічний і синтаксичний); відзначено залучення греко-латинських афіксів та елементів у процесі термінотворення.
АРХЕТИПОВИЙ СИМВОЛ СЕРЦЕ В СУЧАСНІЙ УКРАЇНСЬКІЙ НЕВЕРБАЛІЦІ
Authors: Осіпова Т. Ф.
Published: November 2024

У статті проаналізовано репрезентацію архетипового символа СЕРЦЕ засобами невербальної комунікації з урахуванням асоціативно мотивованої візуалізації зазначеного жесту як семіотичного знака і невербального концепту в аспекті його семантики, прагматики, оцінки. Продемонстровано єдність вербального і невербального складників комунікативної лінгвістики, феномена вербалізації невербаліки в сучасному художньому й публіцистичному дискурсі.
«НЕВИЗНАЧЕНІСТЬ» ЯК ЕЛЕМЕНТ ІКОНІЧНОСТІ В ТЕКСТАХ ЖАХІВ: ПОСТАНОВКА ПРОБЛЕМИ
Authors: Сазонова Я. Ю.
Published: November 2024

У статті розглянуто лінгвістичне вираження поняття невизначеності як елемент іконічності в текстах жахів. Дослідження припускає, що мовні маркери невизначеності, зокрема займенник something, слугують психологічними та онтологічними інструментами у створенні вигаданих світів жахів. Стаття також торкається ширших імплікацій іконічності в мові: мовна невизначеність, пов’язана з когнітивними та емоційними реакціями, демонструє, як прості граматичні структури можуть викликати очікувані емоції, наприклад, коли в текстах жахів «something» асоціюється з негативними або загрозливими конотаціями, на відміну від стандартних текстів англійською мовою, де воно залишається нейтральним або позитивним.
ПРИРОДА Й ФУНКЦІЇ НОМІНАТИВНИХ ТА ІНФІНІТИВНИХ РЕЧЕНЬ У ПОЕТИЧНОМУ МОВЛЕННІ
Authors: Олексенко О. А.
Published: November 2024

Актуальність теми статті полягає в необхідності дослідити вира-
жальні можливості номінативних та інфінітивних речень у поетичному
мовленні з огляду на їхню когнітивну природу, такий підхід відповідає сучасній науковій парадигмі. Мета статті – на основі вчення Л.С. Виготського про зв’язок мислення і мовлення з'ясувати когнітивно-психологічні причини поширеності в українських поетичних текстах названих типів речень, окреслити семантичні нюанси їхнього художнього наповнення у зв’язку з процесом мислення і його образним відображенням у синтаксичній структурі тексту. Висновки заґрунтовані на активності названих типів речення у чотирьох процесах моделювання внутрішнього потоку свідомості автора чи ліричного героя.
МОВНІ ВИЯВИ БІБЛІЙНОСТІ В ПОЕЗІЇ МАКСИМА КРИВЦОВА
Authors: Піддубна Н. В.
Published: November 2024

У статті розглянуто вербалізацію біблійності через актуалізацію бі-
блійної прецедентності й біблійної символіки як прикметну рису лінгвопоетики М. Кривцова. Топонім Голгофа зазнає граматичної і семантичної трансформації, що є засобом граматичної виразності поетичного тексту і виявом потенціалу поетичної граматики. Антропоніми-бібліїзми набувають, окрім біблійного символьного значення, національної прецедентності: відбувається накладання загальновідомої біблійної символіки на національно зумовлену, ресакралізація біблійного антропонімікону на тлі національного контексту. Це вможливлює
посилення художньо-виражальних можливостей текстів і вербалізує новітню сакралізацію подвигу українських воїнів і всього українського народу.
ЗАГАЛЬНИЙ ОГЛЯД КОМП’ЮТЕРНО-МОВОЗНАВЧИХ НАУКОВИХ ПРОЄКТІВ УКРАЇНИ
Authors: Нікуліна Н. В.
Published: November 2024

У пропонованій статті проаналізовано мовознавчі наукові проєкти з використанням комп’ютерних технологій, зокрема онлайновий засіб проведення асоціативних експериментів «Стимулус», зацифрування унікальної архівної лексичної картотеки, цифрові проєкти й засоби для української мови від гурту r2u, Генеральний регіонально анотований корпус української мови, більш відомий під абревіатурою ГРАК. Описано загальну інформацію про проєкти, проведено аналіз технічних особливостей і деталей сервісів, параметрів та структури інтерфейсів користувача, зібрано інформацію про долучення здобувачів різних рівнів освіти до опрацювання текстових масивів.
ЗНАНИЙ МОВОЗНАВЕЦЬ І НЕПЕРЕВЕРШЕНИЙ ПЕДАГОГ – ЮНИМ ЛІНГВІСТАМ
Authors: Космеда Т. А.
Published: November 2024

У 2024 році українська лінгвістична навчальна термінографія поповнилася важливим виданням, якого давно очікували вчителі й школярі. 2024 рік – рік 100‑літнього ювілею доктора філологічних наук, професора, багаторічного працівника Харківського національного педагогічного університету імені Г. С. Сковороди, відомого українського мовознавця, прекрасного педагога, чудового організатора науки й унікальної, світлої, теплої людини – Сергія Івановича Дорошенка.
The Role of Social Movements in Reducing Harmful Corporate Practices Comment on "National Public Health Surveillance of Corporations in Key Unhealthy Commodity Industries – A Scoping Review and Framework Synthesis"
Authors: Freudenberg Nicholas
Published: November 2024

Systematic public monitoring of the practices of corporations that harm health is a necessary but not sufficient measure to reduce the adverse impact of these practices. By supporting social movements and health activist campaigns that seek to modify the corporate structures, systems and practices that harm health, public health professionals and researchers can bring powerful new voices into this crucial public health task. Partnerships between the public health organizations and social movements and activists who seek to make human and planetary well-being more important objectives than higher corporate profits can help to achieve this aim. Public health professionals can play an important role in supporting such partnerships.
Health and Social Care Inequalities During the First Wave of COVID-19 in Italy; Comment on "Experiences and Implications of the First Wave of the COVID-19 Emergency in Italy: A Social Science Perspective"
Authors: Pecoraro Fabrizio
Published: November 2024

The impact of COVID-19 on the Italian population is well-known and has been deeply analysed under the clinical and epidemiological perspectives where the majority of the studies focused on the beginning of the first wave (March-May 2020). However, there is a need for analysing this complex phenomenon integrating the clinical side with the economic and social lens to better understand implications of a pandemic for populations. In their paper Masino and Enria focused the attention on four specific perspectives: health system reaction to the pandemic, inequalities in the work world, social care from the elderly point of view and the government communication challenges. In this commentary, I take these different perspectives trying to outline how they have been explored and analysed during these three years after their publication.
Well-Being Economics – From Slogan to Discipline?; Comment on "Can a Well-Being Economy Save Us?"
Authors: Hensher Martin
Published: November 2024

This commentary addresses Ronald Labonté’s recent editorial, "can a well-being economy save us?" It considers how to assess whether well-being economy policy proposals are likely to achieve real change, or simply represent performative sloganeering. It considers Labonté’s discussion of the congruence between the well-being economy and widely held, cross-cultural values. Finally it explores the relationship between "well-being economics" and the key heterodox economic disciplines it has sprung from, especially ecological and feminist economics; and explores the relationship of well-being economics with degrowth and postgrowth economics as policy goals and models, rather than disciplines. Ultimately, a well-being economy can only "save us" if it is fully guided by and constrained within the same hard ecological constraints that must also guide degrowth or post-growth policy prescriptions.
The Problems of Building Construction in Manacapuru-AM: The Correnteza and Terra Preta Neighborhoods
Authors: Moretti Meirelles Célia Regina , de Oliveira Silvana Rodrigues , Carbajal Ballell Rodrigo , Gumbsch Thilo , Oliveira Junior Jair Antônio de , Celuppi Maria Cristina , Assis Gobo João Paulo , Marcondes Flavio , Sant'Anna Silvio , Fehr Lucas , Ferreira Soares Fabiane
Published: November 2024

In Manacapuru, the region of Solimões River is one lowland, which is formed by fragile soil. Construction in these areas can be affected by several difficulties, such as building instability due to the force of waters during floods and rotting of pillars. Other aspects of the phenomena of nature, such as floods, rain, and moisture, require high maintenance expenses and a short life cycle in wooden buildings. These factors make this population more vulnerable, as well as the risk of losing their home, furniture and personal property. This region is undergoing significant transformations, so many parts of the territory are at risk of landslides and soil erosion.The method consisted of a case study, website visits, production of maps with QGIS and Google Earth, redesign of areasvulnerable to flooding and geological risk. The analysis concludes in the neighborhood Terra Preta the possibility of geological risk is high, but contained in the low-lying areas and the stream. The Correnteza neighborhood presents a greater risk of flooding because it has two influences from the Solimões River and the sandy surface river Areal. Most of the buildings are on wooden stilts, and there are more houses with instability and maintenance issues.
The Polygenesis of Capitalism: A Religious Perspective
Authors: Strehle Stephen
Published: November 2024

This article explores some of the religious influences behind the development of capitalism in the modern world. It questions any conception of life that limits its objects or ideas to a singular causal series of actions. It forwards a view of life as a confluence of many forces in a constant state of interaction that come together in creating the world. It rejects any notion that might think capitalism or any system of nature and thought develops in an orderly sequence from a simple linear direction of cause and effect outside a multitude of influences that constitute a network of relations sharing reciprocal information. 1 What the article hopes to display is a few of the religious influences that served in the mix of a multitude of forces in developing the economic system called capitalism. It repudiates those who live in the binary and think it is possible to separate religion from society and the government.
The Need for Affirming Health Care among LGBTQ+ Survivors of Intimate Partner Violence
Authors: M. Bermea Autumn , L. Henderson Tammy
Published: November 2024

Lesbian, gay, bisexual, trans, queer, and others who are not heterosexual and cisgender (LGBTQ+) are a growing population in the United States and globally; however, they are more likely to report health conditions while are simultaneously more likely to struggle attaining patient centered or affirming health care. Struggles to receive care are amplified by the lack of formal policy that views health care as a human right. This population is also more vulnerable to several risk factors, including intimate partner violence (IPV) than cisgender and heterosexual people. Therefore, they are more likely to necessitate medical care due to injuries (e.g., broken bones, vaginal trauma, lost teeth). In the absence of macro-level policy protections, we make the case for patient-centered and affirming health care that addresses health inequities and the negative health outcomes for IPV survivors. We provide recommendations for providers in primary care, emergency rooms, obstetrics and gynecology, and dentistry.
Гендерные особенности эндотелия у больных гипертонической болезнью
Authors: С.Н. Маммаев , Х.И. Ибрагимова , С.С. Заглиева
Published: November 2024

Цель: изучить содержание эндотелина-1 в сыворотке крови и гормонально-метаболические показатели у больных артериальной гипертензией (АГ) в зависимости от пола и возраста. Материалы и методы. У 120 больных женщин АГ изучено состояние гормонального статуса, а также эффективность монотерапии ирбесартаном. Результаты. Установлены гендерные и возрастные различия содержания эндотелина-1. У женщин в постменопаузе установлено наличие достоверных корреляционных связей между концентрацией эндотелина-1 и показателями липидного профиля, а также параметрами суточного мониторинга артериального давления. Высокий уровень эндотелина-1 способствует возникновению АГ у женщин в постменопаузе, что свидетельствует о максимальной выраженности эндотелиальной дисфункции и преобладании вазоконстрикторных эффектов эндотелина-1 в периоде постменопаузы. Заключение. Выявленные корреляционные связи подтверждают патогенетическую роль изменения гормонального статуса в прогрессировании эндотелиальной дисфункции и АГ.

Objective. to study the content of endothelin-1 in the blood serum and hormonal-metabolic parameters in patients with arterial hypertension (AH) depending on gender and age Material and methods. In 120 sick women with AH, the state of hormonal status was studied, as well as the effectiveness of irbesartan monotherapy. Results. Gender and age differences in the content of endothelin-1 were established. In postmenopausal women, the presence of reliable correlation between the concentration of endothelin-1 and the lipid profile, as well as the parameters of daily monitoring of blood pressure was established. A high level of endothelin-1 contributes to the occurrence of hypertension in postmenopausal women, which indicates the maximum severity of endothelial dysfunction and the predominance of the vasoconstrictor effects of endothelin-1 in the postmenopausal period. Conclusion. The revealed correlation relationships confirm the pathogenetic role of changes in hormonal status in the progression of endothelial dysfunction and increased blood pressure.
Роль лучевых методов исследования в диагностике остеопороза
Authors: С.А. Абдулкадыров , П.А. Таибова , У.Г. Акамова
Published: November 2024

Цель данной статьи показать актуальность проблемы и современные методы диагностики и профилактики остеопороза у пациентов разного возраста и пола. Материалы. Использованы материалы научных статей и монографий, данные ВОЗ. Результаты. Анализ применения различных методов исследования, их преимущества и недостатки. Рентгеновская абсорбциометрия в настоящее время является наилучшим методом диагностики остеопороза и оценки риска переломов. Заключение. Диагноз остеопороза зачастую устанавливается после травматических повреждений. Ранняя диагностика остеопороза имеет огромное значение для предотвращения осложнений , приводящих к инвалидизации больных .На сегодняшний день медицина располагает различными возможностями диагностики данной патологии, основанными на использовании высокотехнологичных методов лучевой диагностики.

The purpose. of this article is to show the relevance of the problem and modern methods for the diagnosis and prevention of osteoporosis in patients of different ages and sex. Materials. The materials of scientific articles and monographs used by WHO are used. Results. Analysis of the application of various research methods, their advantages and disadvantages. X-ray absorptiometry is currently the best method for diagnosing osteoporosis and assessing the risk of fractures. Conclusion The diagnosis of osteoporosis is often established after traumatic injuries. Early diagnosis of osteoporosis is of great importance to prevent complications leading to disability of patients. Today, medicine has various diagnostic capabilities for this pathology, based on the use of high-tech methods of radiation diagnosis.
MtDNA polymorphism and its role in adaptation to environmental conditions and predisposition
Authors: M.V. Golubenko
Published: November 2024

Objective: analysis of the role of population polymorphism of human mtDNA in the formation of hereditary adaptation to extreme environmental conditions and predisposition to diseases. Materials and methods. Genotyping of mitochondrial DNA (mtDNA) is carried out by using various methods, including modern high-performance sequencing technologies. Phylogeographic studies make it possible to reconstruct the family tree of human mtDNA and assess the prevalence of characteristic haplotypes in various populations. Studies of the associations of mtDNA polymorphism with diseases are based on a comparison of the prevalence of haplotypes and individual mtDNA variants in patient groups with ethnically relevant control samples. Results. The results of studies of mtDNA polymorphism in human populations from different geographical regions indicate that some haplotypes and individual variants of mtDNA can play a role in adaptation of the population to high altitude conditions. Studies of the associations of mtDNA polymorphism with multifactorial diseases have revealed haplogroups and individual mtDNA polymorphisms that affect the risk of developing diseases and their complications depending on the population. Cunclusion. The study of mitochondrial genome polymorphism is important for the purposes of population, evolutionary and medical genetics. In addition, these studies are of interest to specialists in the history of ethnic groups and cultures and have an interdisciplinary importance. The study was supported by RFBR grant No. 19-04-01322-A.
Prevention and treatment of thromboembolic complications in gynecology
Authors: R.I. Ragimova
Published: November 2024

Objective: to improve the results of the prevention of early thromboembolic complications in gynecological practice. Material and methods. A review of the literature on the feasibility study after gynecological surgery is presented. The frequency of occurrence of feasibility study and thromboembolism of the pulmonary artery and the percentage of deaths. The classification of patients and their division into 4 groups is given depending on the degree of risk of postoperative venous thrombotic complications in operative gynecology. Results. Causal and predisposing factors and pathogenesis of pulmonary embolism are described in detail. Particular emphasis in the article is placed on hereditary disorders of the blood coagulation system - thrombophilia. The classic signs of the manifestation of the feasibility study and the diagnostic methods of the feasibility study using modern laboratory (D-dimer, etc.) and instrumental methods, including multi-detector computed tomography are reflected. The methods of treatment (medication and invasive) and prophylaxis (medication, mechanical and combined) of early postoperative feasibility studies in operative gynecology are proposed. Conclusion The analysis will significantly improve the issues of early diagnosis, the choice of treatment and prevention of early postoperative feasibility studies after gynecological operations
Genetic factors of vitamin D3 deficiency and their clinical significance
Authors: N.Kh. Omarova , E.M. Soltakhanov , P.A. Omarova
Published: November 2024

Objective: to analyze the available literature data on genetic polymorphisms that affect the metabolism of vitamin D3 and its concentration in blood serum, with an emphasis on the latest experimental and clinical data. Material and methods. A search and analysis of scientific papers and review articles on the effect of genetic polymorphisms in genes (GC, CYP2R1, CYP27A1, DHCR7, VDR) on the metabolism of vitamin D3 and on the subsequent realization of its pleiotropic effects was carried out. Results. The role of hereditary factors in changes in serum indices of vitamin D3 is 23-80, along with indicators such as the UV index, skin insolation, nutritional route of administration, or with drugs. The review analyzed data on the genetic polymorphisms of the GC (DBP), CYP24A1, CYP2R1, CYP27B1, VDR, NADSYN1 / DHCR7 genes, which are involved in the metabolism of vitamin D3 and their association with blood vitamin D3, and analyzed the relationship between vitamin D3 and genetic polymorphisms. The very state of hypovitaminosis D3 increases the likelihood of developing diseases such as type 2 diabetes mellitus, cardiovascular disease, and hypertension. Conclusion. Knowledge of hereditary risk factors for low levels of vitamin D3 can be of great practical importance for the personalization of therapeutic and preventive measures.
Ecological aspects of toxoplasmosis
Authors: T.V. Tsarueva , A.N. Dzhalilova , R.K. Adzhieva , M.A. Korkmasova , A.M. Kasumova , M.K. Yusupova
Published: November 2024

Objective: to study the effect of high altitude on toxoplasma infection and immunological parameters of women of reproductive age with toxoplasma invasion. Material and methods. A survey of 380 patients of reproductive age with a chronic form of toxoplasmosis from high-mountainous regions and 260 patients from lowland areas was examined. In the study of the cellular and humoral parts of the immune system, phagocytosis indices and immunoglobulin classes M, G, A were determined by the Mancini method of radial immunodiffusion. Results. Patients of reproductive age revealed a distinct relationship between infection with toxoplasmosis and high altitude. When analyzing the climatic conditions, the characteristics of the economic activity and life of residents of different settlements of the republic, the dependence of the level of Toxoplasma infection on such factors as the influence of the sea and mountain climate and occupation is revealed. It was found that in patients from high mountain regions, the average percentage of blast formation is 2 times less than this indicator in patients from lowland areas (2.80.3 and 5.70.7 p 0.05). The average percentage of agglomerated leukocytes in individuals from high mountain regions was 16.71.2, and in women from lowland regions - 10.51.1. The difference in leukergy indices was significant (p 0.05). Conclusion. The results of the studies indicate the inhibitory effect of the high mountain climate on the cellular and humoral parts of the immune system. The infection of patients with toxoplasmas from highlands is 2 times higher than among women from lowland areas.
Hypothyroidism and its role in the development of disorders of carbohydrate and fat metabolism (Literature review)
Authors: I.M. Magomedova , K.G. Kamalov , M.G. Ataev , A.Ch. Arslanbekova
Published: November 2024

Objective: to present the results of some works demonstrating the mechanisms of the action of thyroid-stimulating hormone on the processes of regulation of carbohydrate metabolism, as well as its correlation with weight gain. Results. A decrease in the level of thyroid hormones has an effect on the liver, thus causing changes in carbohydrate metabolism, for example, as insulin antagonists by increasing the expression of the glucose transporter type 2. An increase in the concentration of thyroid-stimulating hormone is associated with a risk of lipid and carbohydrate metabolism disorders and therefore, increased chances of developing metabolic syndrome, diabetes mellitus and other disorders of carbohydrate metabolism. Conclusion. All this shows the importance of the problem of combined diabetes mellitus and thyroid diseases, in particular hypothyroidism.
Synthesis and antibacterial properties of modified thin films of TiO2
Authors: A.I. Abdulagatov , R.R. Amashaev , A.M. Maksumova , K.N. Ashurbekova , A.A. Aliev , R.Kh. Isaeva , M.Kh. Rabadanov , I.M. Abdulagatov
Published: November 2024

Objective: determination of the antibacterial properties of modified TiO2 films on the colonies of Staphylococcus aureus and Escherichia coli bacteria. Comparison of antibacterial properties of samples of TiO2 films doped with different elements. Materials and methods. Synthesis and modification of TiO2 films were carried out by atomic / molecular-layer deposition in a hot-wall reactor. The antibacterial properties of the films were determined by comparing the concentrations of bacterial cultures of S. aureus and E. coli irradiated with UV and natural light in the presence of TiO2 films with the control. Results. The lowest concentration of bacterial cultures after the incubation period was in the case of the TiON and TiAlN samples, which indicates that they are the most effective. The samples of TiN and V2O5: TiO2 films showed relatively high activity. In the case of undoped TiO2, the lowest activity was observed compared to other samples, which confirms the absence of antibacterial properties for TiO2 in the visible spectra. Cunclusion. The tested samples of TiO2-based thin films (doped with N, C and vanadium), obtained by Atomic and Molecular Layer Deposition Techniques, have high antibacterial activity against bacterial cultures of sanitary indicative microorganisms Staphylococcus aureus and Escherichia coli.
Thyperoxidase activity and cytochemical indices of blood neutrophils in autoimmune thyroiditis
Authors: TM. Dibirov , MM. Bakuev , RK. Shakhbanov , UB. Alieva
Published: November 2024

Objective: a study of the activity of thyroperoxidase and cytochemical indices of blood neutrophils during autoimmune thyroiditis and the establishment of their possible interrelations depending of the severity of the process. Materials and methods. The material for histochemical studies was pieces of thyroid tissue taken from 27 patients with autoimmune thyroiditis after its subtotal resection. For cytochemical studies was used venous blood taken from the same patients at admission, as well as on the 2nd and 5th day after surgery.The control was venous blood taken from 10 healthy volunteers aged 2045 years. Materials and methods. In patients with autoimmune thyroiditis in the hypothyroidism stage, when formulating a reaction to thyroperoxidase in thyroid preparations, most of the visual field is occupied by large lymphocytic infiltrates. Results. There are single follicles of small size with moderate and weak enzyme activity between them. Separate adenomatous foci, without visible lumen, contain a small amount of colored reaction products and in cases of severe course of the process only their traces are revealed.Myeloperoxidase activity in neutrophils with hypothyroidism is increased (P 0.01).The content of glycogen and lipids in the neutrophils of the blood of this group of patients is also increased.The increase in the content of cationic proteins suggests that a significant increase in the cytochemical indices of neutrophils in this research variant is a consequence of the intensification of synthetic processes in cells at the stage of their development.The body responds as a stress to the decrease in the content of thyroid hormones in the form of activation of synthetic processes in cell structures, including blood cells. Conclusion. Epithelial parenchyma of the gland in hypothyroidism is gradually replaced by lymphoid infiltrates.The activity of thyroperoxidase in autoimmune thyroiditis in the hypothyroidism phase is low and is directly dependenton the severity of the pathological process.The studied cytochemical indices of neutrophils in patients with autoimmune thyroiditis with hypothyroid syndrome were significantly elevated, which is especially pronounced in the last phase of the disease
The case of "tetanus" syndrome in neurology
Authors: AM. Gusniyev , MM. Kurmaliyev , MG. Ataev , A. Magomedova
Published: November 2024

The article describes a clinical case of conversion disorder with generalized muscle cramps occurring under the guise of tetanus. The problem in diagnostics arose after the appearance of relapses of tetanus and the absence of the effect of tetanus treatment. Infectious disease specialists, neurologists and psychiatrists examined the patient. After numerous studies, they diagnosed conversion disorders according to the variant of convulsive syndrome.
Genetic factors in development of cardiovascular diseases in women in menopause
Authors: ZA. Abusueva , TH. Khashaeva , BA. Abusueva , ON. Stefanian , SM. Mamaeva , AM. Tetakaeva , KB. Manysheva
Published: November 2024

Objective. To determine the frequency of different allelic variants of the plasminogen activator inhibitor type 1 (PAI-1) and methylene tetrahydrofolate reductase (MTHFR) among postmenopausal women with coronary heart disease (CHD) and arterial hypertension (AH). Materials and methods.There were examined 125 women of menopausal age with postmenopause duration from 3 to 18 years.The main group consisted of 32 women with CHD and 37 with hypertension.The control group consisted of 56 conditionally healthy women.The study of genetic polymorphism was performed using the method of allele-specific polymerase chain reaction, followed by hydrolysis of amplicons with an appropriate restriction endonuclease. Results.This is a clear link between the risk of cardiovascular disease and an increase in the level of PAI-1 in the blood among postmenopausal women, due to the presence of the 4C allele of the PAI-1 gene and the genetic polymorphism of MTHFR in their genotype. Increasing of the concentration of PAI-1 is among the genetic causes of reduced fibrinolytic activity and tendency to thrombosis in women with menopausal syndrome, which is associated with the risk of myocardial infarction, diabetes mellitus type 1. The regulation of fibrinolysis is closely related to the concentration of homocysteine in the blood. One of the reasons for moderate hyperhomocysteinemia is the C677T mutation in the MTHFR gene. In women of the main group, 4G alleles in the PAI-1 gene and T alleles in the MTHFR gene are detected more often (38) than in the control group (19).In women with metabolic syndrome, the frequency of the defective 4G allele in the PAI-1 gene is high, with 29 of women having a homozygous genotype - 4G / 4G. Conclusion. In addition to estrogen deficiency, genetic factors also play a role in the development of cardiovascular diseases in postmenopausal women.