bluuebunny/crossref_metadata_2025 huggingface dataset:
Design and Synthesis of a Calcium‐Sensitive Photocage
Authors: Heckman Laurel M. , Grimm Jonathan B. , Schreiter Eric R. , Kim Charles , Verdecia Mark A. , Shields Brenda C. , Lavis Luke D.
Published: May 2016

Photolabile protecting groups (or “photocages”) enable precise spatiotemporal control of chemical functionality and facilitate advanced biological experiments. Extant photocages exhibit a simple input–output relationship, however, where application of light elicits a photochemical reaction irrespective of the environment. Herein, we refine and extend the concept of photolabile groups, synthesizing the first Ca2+‐sensitive photocage. This system functions as a chemical coincidence detector, releasing small molecules only in the presence of both light and elevated [Ca2+]. Caging a fluorophore with this ion‐sensitive moiety yields an “ion integrator” that permanently marks cells undergoing high Ca2+ flux during an illumination‐defined time period. Our general design concept demonstrates a new class of light‐sensitive material for cellular imaging, sensing, and targeted molecular delivery.
Effect of cenosphere surface treatment and blending method on the tensile properties of thermoplastic matrix syntactic foams
Authors: Bharath Kumar B. R. , Zeltmann Steven Eric , Doddamani Mrityunjay , Gupta Nikhil , Uzma  , Gurupadu S. , Sailaja R. R. N.
Published: May 2016

The influence of cenosphere surface treatment and blending method on the properties of injection molded high‐density polyethylene (HDPE) matrix syntactic foams is investigated. Cenospheres are treated with silane and HDPE is functionalized with dibutyl maleate. Tensile test specimens are cast with 20, 40, and 60 wt % of cenospheres using injection molding. Modulus and strength are found to increase with increasing cenosphere content for composites with treated constituents. Highest modulus and strength were observed for 40 and 60 wt % untreated mechanically mixed and treated brabender mixed cenospheres/HDPE blends, respectively. These values are 37 and 17% higher than those for virgin and functionalized HDPE. Theoretical models are used to assess the effect of particle properties and interfacial bonding on modulus and strength of syntactic foams. Brabender mixing method provided highest ultimate tensile and fracture strengths, which is attributed to the effectiveness of Brabender in breaking particle clusters and generating the higher particle–matrix surface area compared to that by mechanical mixing method. Theoretical trends show clear benefits of improved particle–matrix interfacial bonding in the strength results. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43881.
Some general conclusions on Fisher's fundamental theorem of natural selection
Authors: Frisman E. Ya.
Published: May 2016

Possible ways for making general conclusions on Fisher's fundamental theorem on natural selection are discussed in this paper for the following three cases. I. A partially isolated population connected by a two‐way migrant flow with the centre of the specific range. 2. A limited population, i.e. a population wherein the fitnesses of the genotypical groups depend on density. 3. An elementary biocoenosis comprising two competing polymorphic species, each of which is represented by a Mendelian one‐locus population. For all three cases, a function has been found that rises monotonously along the trajectory and plays the same role as the average fitness in Fisher's theorem.
The valuation of classification rates in stepwise discriminant analyses
Authors: Hecker R. , Wegener H.
Published: May 2016

In increasing the number of variables in statistical analyses the probability of finding variables supporting the respective hypotheses by chance increases too. To study this effect on classification rates in stepwise linear discriminant analyses 3176 analyses and classifications were performed with random numbers and varying numbers of total available variable, of samples per group and of finally used variables. The resulting tables and regression formulas demonstrate in an impressive manner the possible danger of overrating the discrimination power of the finally used set of variables.
Supplementary critical values of the wilcoxon matched pair signed rank statistic
Authors: Likeš J. , Laga J.
Published: May 2016

Critical values Tα of the Wilcoxon matched pair signed rank statistic T and the probabilities Pr (T ≤ Tα|N) together with the values Tα + 1 and probabilities Pr(T ≤ Tα + 1|N) are tabulated for α =0.0001, 0.00025, 0.001 and N = 10(1)100.
Structural Characterization of [Zn(O2CAr4F‐Ph)2(TAD)] and Determination of Its Stable Conformation by DFT Calculations
Authors: Kim Namseok , Baek Il Hyun , Yoon Sungho
Published: May 2016

In the titled complex, [Zn(C19H11O2F2)2(C8H22N4)]∙0.5CH2Cl2, the Zn2+ cation, with two axial carboxylate ligands, is located in a hexacoordinate ZnO2N4 environment. Two strong intra‐molecular hydrogen‐bonding interactions (CO⋯ H—N) between the carboxylate ligand and amine are observed, in addition to two weak intra‐molecular interactions among the aromatic C—H moieties and oxygen atoms of the carboxylate ligand. An inter‐molecular interaction is also detected between the aromatic C—H of the carboxylate ligand and the fluoro atom of the other carboxylate ligand. According to B3LYP/LANL2DZ calculations, the energy minimum of the title complex is achieved when the planes of the OCO moieties of the axial carboxylates are perpendicular, as observed in the crystal structure.
Cytokeratin (CK5, CK8, CK14) expression and presence of progenitor stem cells in human fetal thymuses
Authors: Gupta Richa , Gupta Tulika , Kaur Harjeet , Sehgal Shobha , Aggarwal Anjali , Kapoor Kanchan , Sharma Anshu , Sahni Daisy , Singla Suhalika
Published: May 2016

The aim of the current study was to observe the expression of cytokeratins in human fetal thymuses. Specific cytokeratin markers in adult humans and mice have been well described but there has been little similar work on human fetuses. We also aimed to see whether progenitor stem cells that could be harvested to treat various immunodeficiency disorders are present in fetal thymic tissue. Thymuses obtained from 30 aborted human fetuses (12 to 31 weeks) were examined immunohistochemically to investigate changes in cytokeratin expression in the epithelial cells (TEC) at various gestational ages. Before 16 weeks of gestation, cortical (cTEC) and medullary (mTEC) TEC exhibited homogenous staining for cytokeratins CK8 and CK5. After 16 weeks there was differential staining, with cTEC positive for CK8 and mTEC for CK5 and CK14. Interestingly, both CK5 + CK8+ progenitor stem cells were present in the fetal thymic cortex at all gestational ages, with a relatively high number from 12 to 16 weeks. Cytokeratin expression in fetal thymuses was quite different from that in the adult thymus owing to the presence of undifferentiated progenitor stem cells in fetal thymic stroma along with differentiated TEC. The best time to harvest these progenitor stem cells from fetal thymic stroma in order to treat various immune deficiency disorders appears to be 12–16 weeks. Clin. Anat. 29:711–717, 2016. © 2016 Wiley Periodicals, Inc.
Wellbeing of Professionals Working with Suspected Victims of Child Sexual Exploitation
Authors: Ahern Elizabeth C. , Sadler Leslie H. , Lamb Michael E. , Gariglietti Gianna M.
Published: May 2016

The present study examined police officers' and social workers' experiences of investigating child sexual exploitation (CSE) cases and the impact on their welfare. Semi‐structured interviews were conducted with frontline social workers and law enforcement professionals. Practitioners reported that they seldom reacted emotionally during forensic interviews because they were attending entirely to the victims while gathering evidence. Although some practitioners employed post‐interview stress management techniques, anticipatory coping strategies were seldom adopted, and most coping methods were employed outside of the workplace (e.g., spending time with family). Practitioners focused on the needs of young people, almost to the exclusion of their own. Many did not consider the negative emotional impact of CSE cases on their welfare. These findings have important implications for practitioner wellbeing. Copyright © 2016 John Wiley & Sons, Ltd.

‘Examined police officers' and social workers' experiences of investigating child sexual exploitation (CSE) cases and the impact on their welfare’

Key Practitioner Messages

Practitioners rarely considered the emotional effects that CSE cases might have on them or ways to psychologically prepare themselves before meeting with young people.

Practitioners reported a variety of ways they managed the impact of working with CSE which most often occurred outside of the workplace; a number of these ways could be actively promoted and developed within police forces and local authorities, especially preventative coping strategies.

‘Practitioners reported a variety of ways they managed the impact of working with CSE’
Initial Experience With the Pediatric Impella Device: A Feasibility Study in a Porcine Model
Authors: Webb Melissa K. , Wang Jian , Riegel Matthew S. , Guleserian Kristine J. , Forbess Joseph M. , Zellers Thomas M. , Dimas V. Vivian
Published: May 2016

Objective

This study's objective was to evaluate insertion techniques and device fit of the pediatric version of the Impella ventricular assist device in swine which had similar sized carotids and left ventricles (LVs) as children weighing 10–20 kg.

Background

Options for minimally invasive circulatory support in children are limited. A modified device based on the current Impella 2.5 platform was created in an effort to provide minimally invasive circulatory support for children.

Methods

Animal studies (n = 10) were performed to determine technical feasibility of device implant via the right common carotid artery (RCCA) in swine with a carotid and LV size similar to children with a BSA < 1 m2 and weight 10‐20 kg. The RCCA diameter was measured on pre‐implant ultrasound and the LV length was measured at necropsy. The animals were supported for 4 hr and the device explanted. Blood samples and post‐explant necropsy was performed to evaluate for device related complications.

Results

All animals underwent successful device insertion. Mean carotid artery diameter by ultrasound was 3.5 ± 0.3 mm. There was no LV or aortic/mitral valve damage with a minimum LV length of 5.4 cm.

Conclusions

Minimally invasive circulatory support is needed in small children. Limitations are primarily related to vessel and chamber size. The Impella Pediatric catheter was safely and successfully implanted in carotid arteries similar in size to children weighing 10–20 kg with minimal complications. © 2016 Wiley Periodicals, Inc.
Characteristics of Liquid Flow in Microchannels at very Low Reynolds Numbers
Authors: Zhang Xiwen , He Feng , Hao Pengfei , Gao Ye , Sun Liang , Wang Xiaoqi , Jin Xu
Published: May 2016

The flow characteristics of deionized water and kerosene through smooth rectangular microchannels with varying hydraulic diameters are studied experimentally. Through the special design of the experimental setup, a wide range of measured average liquid velocities in microchannels is achieved, corresponding to broad‐ranging Reynolds numbers. The experimental data indicate that the pressure drop exhibits a linear relationship with the average velocity of the fluid in microchannels whose scales are larger than 2 μm. Moreover, the experimental Darcy friction factor is consistent with the classical laminar flow theory of a Newtonian fluid. Microscopic particle image velocimetry was applied to measure the velocity distribution inside the macrochannels. The experimental results agree well with the classical hydrodynamic theory.
ChemInform Abstract: Magic Angle Spinning NMR Studies of Silicon Carbide: Polytypes, Impurities, and Highly Inefficient Spin‐Lattice Relaxation.
Authors: HARTMAN J. S. , RICHARDSON M. F. , SHERRIFF B. L. , WINSBORROW B. G.
Published: May 2016

The 29Si and 13C MAS NMR spectra of 6H, 3C, and 15R polytypes of SiC are reported.
ChemInform Abstract: Influence of Process Variables on Microstructure and V‐I Characteristics of Multicomponent ZnO‐Based Nonlinear Resistors.
Authors: ASOKAN T. , IYENGAR G. N. K. , NAGABHUSHANA G. R.
Published: May 2016

The effects of process variables such as calcination, initial particle size, and postsintering on the properties of a ZnO‐based composite containing additive oxides such as Nb2O5, Bi2O3, Sb2O3, CoO, MnO2, and Cr2O3 has been investigated.
ChemInform Abstract: Oxygen Content of Superconducting Perovskites, La2‐xSrxCuOy and YBa2Cu3Oy.
Authors: APPELMAN E. H. , MORSS L. R. , KINI A. M. , GEISER U. , UMEZAWA A. , CRABTREE G. W. , CARLSON K. D.
Published: May 2016

A modified iodometric titration method that is believed to be an accurate and efficient procedure for measuring the Cu(III) content of Cu(II),Cu(III)‐containing superconducting oxides and, thus, the oxygen content, is developed and described.
ChemInform Abstract: In situ Laser Raman Determination of Electrochemical Reactions of Y2O3‐Stabilized ZrO2 and Molten Na2SO4.
Authors: WINDISCH C. F. JUN. , BATES J. L. , BOGET D. I.
Published: May 2016

In situ laser Raman spectroscopy has been used successfully to investigate reactions near the interface between a Y2O3‐stabilized ZrO2 (YSZ) electrode and molten sulfate.
ChemInform Abstract: Synthesis of (S)‐(‐)‐2‐(Trifluoromethyl)‐3‐hydroxypropanoic Acid by Asymmetric Hydrolysis.
Authors: YAMAZAKI T. , MURATA K. , KITAZUME T.
Published: May 2016

Hydrolysis of the ester (I) by lipase‐My leads to the title compound (II).
ChemInform Abstract: Tetrahydropentalenes.
Authors: PAULI A. , MEIER H.
Published: May 2016

The pentalene (I), obtained from cyclooctatetraene, can be reduced by LiAlH4 to the isomeric tetrahydropentalenes (II) and (III).
ChemInform Abstract: Direct Ring Proton‐Transfer Reaction via a Transient Hydrogen Bond Bridged Allyl Anion System on the Models of Cycloheptatrienes and Propene.
Authors: TAKAHASHI K. , SUZUKI T. , TODA H. , TAKASE K. , KOSEKI S. , NAKAJIMA T.
Published: May 2016

The cycloheptatriene derivatives (I) form the isomerization products (II) and (III) on treatment with a base via a direct 1,3‐proton shift.
ChemInform Abstract: Oxidations with Cerium(IV) Sulfate: Intramolecular Cyclization of N‐Benzyl‐β‐amino Ketones Yielding 4‐Benzoyl‐1,2,3,4‐tetrahydroisoquinolines.
Authors: HOLZGRABE U.
Published: May 2016

The benzaldehydes (I) are reductively coupled with methylamine hydrochloride (II) to produce the N‐benzyl‐N‐methylamines (III) which react with the amino ketone (IV), yielding the tertiary amines (Vb) ‐ (Vd).
ChemInform Abstract: Syntheses with Nitriles. Part 77. Synthesis and Structure Analysis of 4‐Amino‐5‐cyano‐1‐phenyl‐3‐pyridazinecarboxylates.
Authors: MITTELBACH M. , WAGNER U. , KRATKY C.
Published: May 2016

Reaction of the butenoates (II) with the diazonium salt (I) yields the open‐chain adduct (III) which is cyclized to give the pyridazinecarboxylate (IVa).
ChemInform Abstract: Phosphorus Compounds with Unusual Coordination. Part 19. 1,2,4‐Diazaphospholes by (3 + 2) Cycloaddition of Diazo Compounds onto a Stable Phosphaalkyne.
Authors: ROESCH W. + , HEES U. , REGITZ M.
Published: May 2016

The diazomethyl compounds (II) add regiospecifically onto the phosphaalkyne (I) to give the adducts (III) which isomerize by spontaneous H‐shift to the 1,2,4‐diazaphospholes (IV).
ChemInform Abstract: Chemo‐, Regio‐ and Stereoselectivity of the Reaction of Dialkyl 1,2‐Alkadienylphosphonates with Selenenyl Chlorides. 1,3‐Sigmatropic Rearrangement of 2,3‐Adducts.
Authors: MONDESHKA D. M. , TANCHEVA C. N. , ANGELOV C. M.
Published: May 2016

Reaction of the allenylphosphonates (I) with the selenenyl chlorides (II) yields a complex product mixture, consisting of the compounds (III) ‐ (VI).
ChemInform Abstract: Incorporating CO into Poly(alkoxymethylene)acyl Ligands. Converting (Ph2PCH2CH2PPh2)(CO)2Co‐COCH3 into threo‐(dppe)(CO)2Co‐COCH(OEt)CH(OEt)CH3.
Authors: TSO C. C. , CUTLER A. R. , KULLNIG R. K.
Published: May 2016

Alkoxyacyl complexes are obtained from acyl derivatives by electrophilic activation of an acyl ligand, hydride transfer to its oxycarbenoid derivative and carbonylation of the resulting alkoxy group.
ChemInform Abstract: Novel Basic Ligands for the Homogeneous Catalytic Methanol Carbonylation. Part 9. Synthesis and Reactivity of Ruthenium(II) Complexes with Ether Phosphane Ligands.
Authors: LINDNER E. , SCHOBER U. , FAWZI R. , HILLER W. , ENGLERT U. , WEGNER P.
Published: May 2016

The ether phosphane ligands (II) react with RuCl3·3 H2O (I) to give the complexes (III) in which the P,O ligands (II) function as bidentates.
ChemInform Abstract: Nonproteinogenic Amino Acids. Part 4. EPC Synthesis of L‐(+)‐Forphenicine.
Authors: WEINGES K. , REINEL U. , MAURER W. , GAESSLER N. +
Published: May 2016

In order to avoid losses in the optical resolution of (±)‐forphenicinol (VI) and (±)‐forphenicine (VII), the synthesis of these compounds is initiated with 3‐methoxybenzaldehyde and the corresponding chiral aminodioxane followed by HCN‐addition to yield an 8:2‐mixture of (I) with its (2R)‐diastereomer.
ChemInform Abstract: Influence of Heating Conditions and Flux on the Luminescence Properties of Ba0.9Eu0.1Mg2Al16O27.
Authors: NOETZOLD D. + , HERZOG G. , LIEBENOW B.
Published: May 2016

The title phosphors, prepared by heating the corresponding amounts of Ba(NO3)2, Mg(HCOO)2, Al(OH)3 (as solids), and Eu(NO3)3 (as aqueous solution) in the presence of NaF, Na3AlF6 or AlF3·0.5 H2O as fluxes to temp. between 1643 and 1723 K, show as small emission band peaking in the spectral range between 460 and 467 nm.
ChemInform Abstract: The Influence of Hydrofluoric Acid and Fluoride Ion on the Corrosion and Passive Behavior of Titanium
Authors: WILHELMSEN W. , GRANDE A. P.
Published: May 2016

has been studied by stationary and transient polarization measurements on Ti electrodes in HCl/HF and NaOH/NaAc/NaF mixtures of varying F‐ content and the oxide films formed are studied by AES and ESCA.
ChemInform Abstract: Metal Colloids Produced by Means of Gas Evaporation Technique. Part 4. Size Distribution of Small Mg and In Particles.
Authors: KIMURA K.
Published: May 2016

Small metal particles (Mg in THF and In in acetone) have been prepared by the matrix isolation method, the gas flow‐solution trap method, and the gas flow‐cold trap method and the size distribution of the particles has been determined by electron microscopy.
ChemInform Abstract: New Potassium Aluminum Hydrides with Elpasolite‐type Structure Obtained by High Pressure Synthesis.
Authors: BASTIDE J.‐P. , CLAUDY P. , LETOFFE J.‐M. , EL HAJRI J.
Published: May 2016

The compounds (III), (V), and (VII), all belonging to the elpasolite family A2BMX6, have been prepared as shown in the scheme (no yields given).
ChemInform Abstract: RbxP8W8O40: A Diphosphate Bronze with Octagonal Tunnels. Study of the Structure and Comparison with CsP8W8O40.
Authors: LAMIRE M. , LABBE PH. , GOREAUD M. , RAVEAU B.
Published: May 2016

Single crystals of Rb0.5P8W8O40 are obtained by preannealing a mixture of Rb2CO3, (NH4)2HPO4, and WO3 to decompose the carbonate and phosphate (873 K) and subsequent addition of metallic tungsten to obtain a stoichiometric mixture which is then annealed at 1173 K for 5 d. The compound crystallizes in space group Ccm21.
ChemInform Abstract: Equilibrium and Kinetic Analysis of the Interaction of Mercury(II) with Cadmium(II) Metallothionein.
Authors: JOHNSON B. A. , ARMITAGE I. M.
Published: May 2016

The results show that Hg(II) quantitatively displaces Cd(II) from the protein.
ChemInform Abstract: Anodic Oxidation of Cycloaliphatic Mono‐ and Diethers in Aqueous Electrolytes.
Authors: WERMECKES B. , BECK F.
Published: May 2016

The primary products of the anodic oxidation of (II), (IV), and (IX) are the cyclic hemiacetals (I) and (V) in all cases.
ChemInform Abstract: Reaction of Aminonitrenes with Azo Compounds. Part 4. Addition of Phthalimidonitrene to Unsymmetrical E‐Azoalkanes.
Authors: SUVOROV A. A. , MALOV M. YU. , KUZNETSOV M. A.
Published: May 2016

The reaction between phthalimidonitrene, generated in situ from N‐aminophthalimide (II) and Pb(OAc)4, and the unsymmetrically substituted E‐azoalkanes (I) affords mixtures of the regioisomeric 2Z‐2,3‐dialkyl‐1‐phthalimidoazimines (III) and (IV).
ChemInform Abstract: 1,3‐Dipoles Are Not the Only Reactive Species in 2‐Acylaziridine Pyrolyses.
Authors: VEDEJS E. , WISNIEWSKI GRISSOM J. , PRESTON J. K.
Published: May 2016

The N‐(tert‐butyl)benzoylaziridines (I) undergo thermolysis to produce the intermediate oxazolines (III) via the dipoles (II).
ChemInform Abstract: Photosensitized Oxidation of Maleic Acid by Singlet Oxygen.
Authors: AGARWAL S. K. , AMETA S. C. , JAIN P. K.
Published: May 2016

Photosensitized oxygenation of maleic acid (I) in pyridine yields racemic tartaric acid (±)‐(II).
ChemInform Abstract: A New Synthesis of Aromatic and Heteroaromatic Nitrogen Mustards via 3‐Pyrrolines.
Authors: PALMER B. D. , DENNY W. A.
Published: May 2016

Pure 3‐pyrroline (II) is obtained by cyclization of cis‐1,4‐dichloro‐2‐butene (I) with ammonia.
ChemInform Abstract: Synthesis of Some Furo(2,3‐b) and (3,4‐c)cycloheptatriene Derivatives.
Authors: EL BORAI M. , HASSAN M. A. , MOHAMED M. M.
Published: May 2016

The isomeric furocycloheptatrienones (I) and (V) are allowed to react with the organolithium compounds (II).
ChemInform Abstract: Detection of an Azomethine Ylide and Its Conversion to Aziridine.
Authors: VEDEJS E. , DAX S. , MARTINEZ G. R. , MCCLURE C. K.
Published: May 2016

The imine (I) is coupled with the trifluoromethanesulfonate (II) to produce the salt (III).
ChemInform Abstract: Unusual Reactions of Magnesium Indolates with Benzenesulfonyl Chloride.
Authors: WENKERT E. , MOELLER P. D. R. , PIETTRE S. R. , MCPHAIL A. T.
Published: May 2016

The indolylmagnesium compounds, derived from indole (Ia) or skatol (Ib), react with the sulfonyl chlorides (II) or (V), yielding the substituted indoles (III) or (VI).
ChemInform Abstract: Synthesis and Antiviral Activity of 1‐Alkyl(Aryl)‐2‐alkylaminomethyl‐3‐ ethoxycarbonyl‐5‐hydroxy‐6‐bromoindoles.
Authors: GRINEV A. N. , PANISHEVA E. K. , NIKOLAEVA I. S. , FOMINA A. N. , GOLOVANOVA E. A. , CHERKASOVA A. A.
Published: May 2016

The compounds (IV) mentioned in the title are prepared by condensation reaction of the bromomethylindoles (I) with the amines (II) and subsequent alkaline hydrolysis.
ChemInform Abstract: A New Preparative Method, Characterization, and Reactivity of Disulfide Dication Salts of Bicyclic Disulfides: R2S+‐+SR2.2CF3SO3‐.
Authors: FUJIHARA H. , AKAISHI R. , FURUKAWA, , N.
Published: May 2016

The dithiacycloalkane 1‐oxides (I) and (VII) are converted to the corresponding bicyclic disulfide dication salts (II) and (VIII) respectively by treatment with trifluoromethanesulfonic anhydride.
ChemInform Abstract: Synthesis and Choleretic Activity of 3‐(2‐Aryl‐5‐R‐benzimidazol‐1‐yl)butanoic Acids.
Authors: GRELLA G. E. , PAGLIETTI G. , SPARATORE F. , MANCA P. , SATTA M.
Published: May 2016

The o‐chloronitrobenzenes (I) react with aminobutyric acid (II) to give the o‐aminonitrobenzenes (III) which are reduced, yielding the o‐phenylenediamines (IV).
ChemInform Abstract: Synthesis of 1,2,4‐Triazoles and 4‐Amino‐1,2,4‐δ2‐triazolines from Azines and Nitrilimines.
Authors: VASIL'EVA L. P. , AKIMOVA G. S. , CHISTOKLETOV V. N.
Published: May 2016

The reactions between the azines (I) and the nitrilimines (II), bearing electron‐withdrawing substituents, yield the 1,2,4‐Δ2‐triazolines (III), whereas the aldazines (IV), on reaction with the diarylazines (V), give the 1,2,4‐triazoles (VI).
ChemInform Abstract: Copper Complex Protection in the Regioselective Alkylation of Methyl 3,5‐Dioxohexanoate. Preparation of 3‐Alkyl Derivatives of 4‐Hydroxy‐6methyl‐2‐pyrone.
Authors: CERVELLO J. , MARQUET J. , MORENO‐MANAS M.
Published: May 2016

The β,δ‐diketo ester (I) is converted to the copper complex (II) which is alkylated to form the derivatives (IV).
ChemInform Abstract: Cobalt‐Mediated (2 + 2 + 2) Cycloadditions of Alkynes to the Imidazole 4,5 Double Bond. First Synthesis of the 3a,7a‐Dihydrobenz‐imidazole Nucleus and Its Preliminary Chemistry Including a Novel Quinoline Construction.
Authors: BOESE R. , KNOELKER H.‐J. + , VOLLHARDT K. P. C.
Published: May 2016

The title addition of the alkynes (II) or (V) to the imidazole (I) regioselectively yields the compounds (IVa) or (VI) as major or sole products.
ChemInform Abstract: Free Radicals in Organic Synthesis. A Novel Synthesis of Ethylene Glycol Based on Formaldehyde.
Authors: SANDERSON J. R. , YEAKEY E. L. , LIN J. J. , DURANLEAU R. G. , MARQUIS E. T.
Published: May 2016

Radical‐induced reaction of 1,3‐dioxolane (I) with formaldehyde (II) forms a mixture of the products (III) ‐ (XI).
ChemInform Abstract: Synthesis and Antitumor Activity of 4‐Mercapto‐9‐ethoxycarbonyl‐7,8‐dihydro‐6H‐pyrimido(5,4‐b)pyrrolizine Derivatives.
Authors: KADUSHKIN A. V. , GOLOVKO T. V. , KALISTRATOV S. G. , SOKOLOVA A. S. , CHERNOV V. A. , GRANIK V. G.
Published: May 2016

Starting with the pyrrolidone acetal (I), the compounds (VII) and (XI) mentioned in the title are prepared via the intermediates (III), (IV), and (VI).
ChemInform Abstract: Synthesis, Transformations and Biological Properties of 7,8‐Disubstituted Xanthines.
Authors: STROKIN YU. V. , ZARUDII F. S. , KREMZER A. A. , NAZIPOV N. M. , CHVALYUK N. V. , LAZAREVA D. N.
Published: May 2016

Starting with 8‐bromotheophylline (I), the 7,8‐disubstituted derivatives (III), (IV), (V), (VII), and (VIII) are prepared as shown in the reaction scheme.
ChemInform Abstract: The Vilsmeier‐Haack Reaction of Isoxazolin‐5‐ones. Synthesis and Reactivity of 2‐(Dialkylamino)‐1,3‐oxazin‐6‐ones.
Authors: BECCALLI E. M. , MARCHESINI A.
Published: May 2016

The isoxazolinones (I) undergo ring‐enlargement under Vilsmeier‐Haack conditions to form the oxazinones (III).
ChemInform Abstract: Substituted 1,3,3a,4,5,6a‐Hexahydrooxazolo(4,5‐d)‐1,2,3‐triazoles from a Cycloaddition on a Carbonyl Group. Thermal Ring Expansion: A New Route to Substituted 1,3,4,5‐Oxatriazines.
Authors: BUTLER R. N. , EVANS A. M. , MCARDLE P. , CUNNINGHAM D.
Published: May 2016

The 1,2‐cis‐bis(arylazo)stilbenes (I) react via the cyclic triazolium imide form (II) with cinnamaldehyde (III) to yield the cycloadducts (IV).
ChemInform Abstract: 3H‐Indoles and Acetylenecarboxylic Esters.
Authors: LETCHER R. N. , SIN D. W. M.
Published: May 2016

Dimethyl acetylenedicarboxylate (II) reacts with the indoles (I) to give the tricyclic adducts (III).
ChemInform Abstract: CFCl2‐Substituted Silanes from Chlorosilanes. Part 19. Fluorinated Elementorganica.
Authors: JOSTEN R. , RUPPERT I.
Published: May 2016

The chloromethylsilanes (I) react with fluorotrichloromethane (II) in the presence of tris(diethylamino)phosphine to produce the (dichlorofluoromethyl)silanes (III).
ChemInform Abstract: Sodium Hydridotrimethylboronate and Its Ether Solvate. Study of Hydridotrialkylboronates as Reagents for the Preparation of Beryllium Hydrides.
Authors: BELL N. A. , COATES G. E. , HESLOP J. A.
Published: May 2016

Trimethylborane (I) reacts with sodium hydride, suspended in diethyl ether, to give the etherate (II) which is converted to the title compound (III) by evaporation.
ChemInform Abstract: Mixed‐Ligand Chelate Extraction of Lanthanoids with 1‐Phenyl‐3‐methyl‐4‐(trifluoroacetyl)‐5‐pyrazolone and Some Phosphine Oxide Compounds.
Authors: UMETANI S. , FREISER H.
Published: May 2016

Mixed‐ligand chelate extraction of lanthanoids such as La, Pr, Eu, Ho, Yb into CHCl3 with the title compound HL1 and the three phosphine oxides L2 and L3 is studied.
ChemInform Abstract: Alkylations of Tetracarbonyl(phosphine)chromium and Pentacarbonylchromium Carbene Complexes and Their Reactions with Selected Acetylenes.
Authors: XU Y.‐C. , WULFF W. D.
Published: May 2016

Metalation of the chromium carbene complexes (I) with BuLi yields the anions (II) which are quenched with the alkyl halides or sulfonates (III), yielding the alkylated derivatives (IV).
ChemInform Abstract: A Multiply Bonded Dimetal Complex of the M2L10 Type That Contains π‐Acceptor Ligands and Does Not Possess an Edge‐Shared Bioctahedral Structure. The (Re2Cl3(μ‐dppm)2(CO)(CN‐t‐Bu)2)+ Cation.
Authors: FANWICK P. E. , PRICE A. C. , WALTON R. A.
Published: May 2016

The known complex (I), which does not contain a bridging CO ligand, reacts with further tBuNC (II) as shown to give the title cation complex (III), in which the terminal Re‐CO bond is retained.
ChemInform Abstract: Four‐ and Five‐Coordinate Cobalt(II) Thiolate Complexes: Models for the Catalytic Site of Alcohol Dehydrogenase.
Authors: CORWIN D. T. JUN. , FIKAR R. , KOCH S. A.
Published: May 2016

Bis(thiolato)cobalt complexes are spectroscopic models for the catalytic center in liver alcohol dehydrogenase.
ChemInform Abstract: Ligand Design for Enhanced Stereoselectivity in the Electron‐Transfer Reactions Between Nickel(IV) Bis(oxime‐imine) Complexes and (Co(edta))2‐.
Authors: MARTONE D. P. , OSVATH P. , LAPPIN A. G.
Published: May 2016

A number of derivatives (Ib)‐(Ig) of the bis(oxime‐imine) (Ia) (prepared in general by published methods) are used as ligands for Ni complexes.
ChemInform Abstract: 1,3,5,7‐Tetrathia‐s‐indacene‐2,6‐dione Chemistry. Synthesis of New Multisulfur Donor Molecules and Nickel‐Dithiolene Electron‐Transfer Complexes.
Authors: LARSEN J. , BECHGAARD K.
Published: May 2016

The tetrakis(thioether) (I) is cleaved with sodium and then allowed to react with phosgene (II), producing the tetrathiaindacenedione (III) mentioned in the title.
ChemInform Abstract: Bimetallic Macrocycles Incorporating Deprotonated 2‐Pyrrolidone Bridges: Novel Polymeric Structures in ((Hg2Cu(C4H6NO)4)X2)n (X: NO3, ClO4).
Authors: GOODGAME D. M. L. , WILLIAMS D. J. , WINPENNY R. E. P.
Published: May 2016

The new title complexes (I) are prepared by reaction of Hg acetate with 2‐pyrrolidone and the appropriate Cu(II) salt in MeOH (reflux, 3 d).
ChemInform Abstract: β‐Perfluoroalkyldicarbocyanines.
Authors: PAZENOK S. V. , CHAIKA E. A. , YAGUPOL'SKII L. M.
Published: May 2016

The title compounds (III) and the derivative (V) are prepared.
ChemInform Abstract: Regioselective One‐Pot Approach to Aminodeoxy Sugars via Aminosilanes.
Authors: MALIK A. , KAZMI N. , KHAN A. Q. , AHMAD Z.
Published: May 2016

The 2,3‐anhydro‐α‐D‐allopyranoside (I) is converted to the aminodeoxy‐ α‐D‐glucopyranoside derivative (III) by regioselective trans‐diaxial cleavage of the epoxide ring with N,N‐(diethyl)trimethylsilylamine (II) in the presence of AlCl3.
ChemInform Abstract: Densification and Microstructural Development of SrTiO3 Sintered with V2O5.
Authors: CHEN J.‐S. , YOUNG R.‐J. , WU T.‐B.
Published: May 2016

The use of V2O5 as a liquid‐phase sintering agent promotes the densification of SrTiO3 at low temperature.
ChemInform Abstract: Metal Carbonate Equilibria. Part 18. Lead(II) Carbonate Complexes in Alkaline Solutions.
Authors: FERRI D. , GRENTHE I. , HIETANEN S. , SALVATORE F.
Published: May 2016

The results of potentiometric measurements with a glass electrode and a Pb amalgam electrode at 25 °C strongly indicate the formation of the complexes (I)‐(III).
ChemInform Abstract: EXAFS Characterization of Ru/Al2O3 Catalysts Using Synchrotron Radiation.
Authors: VLAIC G. , BART J. C. J. , CAVIGIOLO W. , FURESI A. , RAGAINI V. , CATTANIA SABBADINI M. G. , BURATTINI E.
Published: May 2016

EXAFS, XPS, and oxygen chemisorption results are reported for Ru/γ‐Al2O3 catalysts prepared from Ru‐acetylacetonate and reduction in hydrogen at 200, 300, or 400 °C for 4 or 8 h. The results indicate a high degree of dispersion of the metal.
ChemInform Abstract: Synthesis and Characterization of Hydrogenphosphates of Formulae MHPO4·3 H2O (I) and (MHPO4)2·3 H2O (II) (M: Co, Ni, Zn).
Authors: CUDENNEC Y. , LECERF A. , RIOU A. , GERAULT Y.
Published: May 2016

The title compounds have been prepared using NiO, ZnO and CoCO3, resp., H3PO4, and H2O as starting materials (greater amount of H3PO4 for the dimeric compounds, 293‐423 K, 10‐90 d).
ChemInform Abstract: A Diffuse Reflectance FTIR Spectroscopic (DRIFTS) Investigation of Carbon‐Supported Metal Carbonyl Clusters.
Authors: VENTER J. J. , VANNICE M. A.
Published: May 2016

For the first time an IR technique is successfully applied to characterize metal carbonyl clusters and CO chemisorbed on metal particles that are dispersed on carbon.
ChemInform Abstract: The Amide 15N Chemical Shift Tensors of Four Peptides Determined from 13C Dipole‐Coupled Chemical Shift Powder Patterns.
Authors: OAS T. G. , HARTZELL C. J. , DAHLQUIST F. W. , DROBNY G. P.
Published: May 2016

The 15N chemical shift tensors of a homologous series of peptides of the form: N‐Ac(1‐13C)gly(15N)‐X‐amide (X: gly, ala, tyr) and the unprotected dipeptide (1‐13C)gly(15N)gly·HCl are determined from 13C dipole‐coupled 15N powder patterns.
ChemInform Abstract: 2‐Cyclopropylidene‐1,3‐cycloalkanediones as Intermediates in a Nucleophilic Substitution at a Three Membered Ring.
Authors: WEIDNER J. , VILSMAIER E. , FRIES R.
Published: May 2016

The morpholinobicycloalkanes (III) are obtained by reaction of the compounds (Ia), (Ib) with dimedone (IIc).
ChemInform Abstract: Aminocyclopropyl Substituted CH‐Acids as Substrates in a Nucleophilic Substitution at a Three‐Membered Ring.
Authors: WEIDNER J. , VILSMAIER E.
Published: May 2016

The piperidinocyclopropane derivatives (III) are readily prepared from the components (II) + (Ia)‐(Ic), (IIIa) is treated with the diones (Ia), (Id)‐(Ig) to give the respective derivatives (IV); in addition, the ring‐opened product (V) is formed and is spectroscopically identified.
ChemInform Abstract: Synthesis of Novel Pyrazole and Isoxazole Derivatives from the Condensation Products of β‐Dicarboxyl Compounds with 1,2,3‐Trihalopropanes.
Authors: AKHMEDOV SH. T. , SADYKHOV N. S. , ISMAILOV V. M. , AKHUNDOVA M. A. , MAMEDOV M. M. , KOZHUSHKOV S. I. , ZEFIROV N. S.
Published: May 2016

The 2‐haloallyl‐1,3‐dicarbonyl compounds (I) react with the hydrazines (II) or with hydroxylamine (IV) in the presence of bases to yield the pyrazoles (III) and the isoxazoles (V).
ChemInform Abstract: A New Reduction with Hydrogen Telluride.
Authors: KAMBE N. , INAGAKI T. , MIYOSHI N. , OGAWA A. , SONODA N.
Published: May 2016

Several reductions are performed using hydrogen telluride which is generated in situ from aluminum telluride and water: the aldehydes (I) are converted to the alcohols (II).
ChemInform Abstract: Enantioselective Alkylations of γ‐Oxo Esters.
Authors: AGAMI C. , MEYNIER F. , RIZK T.
Published: May 2016

The N‐substituted amino alcohols (I), derived from (1R,2S)‐norephedrine, undergo ring closure with 3‐methoxycarbonylpropionaldehyde (II), forming the chiral oxazolidines (III).
ChemInform Abstract: Synthesis of Furans by Acylation of Cyclopropenes.
Authors: BARTMANN E. , GOMPPER R.
Published: May 2016

Reaction of the cyclopropenes (I) with the aluminum trichloride complexes of the acyl chlorides (II) results in ring enlargement, yielding the furans (III).
ChemInform Abstract: Control of Regioselectivity in the Alkylation of 2‐Trimethylsilyl‐2,5‐ dihydrothiophene 1,1‐Dioxide. A Route for 2,2‐Dialkylation.
Authors: TSO H.‐H. , CHOU T. , LEE W.‐C.
Published: May 2016

The sulfolene (I) is lithiated and then coupled with trimethylsilyl iodide (II) to give the 2‐silylsulfolene (III) which is the starting compound for various alkylation experiments.
ChemInform Abstract: Condensation on Alumina. Part 3. Synthesis of 5‐Alkylidene‐2‐thiohydantoin from 3‐Acetyl‐2‐thiohydantoin.
Authors: VILLEMIN D. , RICARD M.
Published: May 2016

3‐Acetylthiohydantoin (IV) is prepared by cyclocondensation of ammonium thiocyanate (I) and glycine (II) in the presence of acetic anhydride (III).
ChemInform Abstract: Synthesis of 3‐(N,N‐Disubstituted Carbamoylmethyl)benzoxazolinones and 2‐(N,N‐Disubstituted Carbamoylmethyl)thioxobenzoxazoles.
Authors: MUKHAMEDOV N. S. , ALIEV N. A.
Published: May 2016

The chloroacetylbenzoxazolinones (I) react with the amines (II) to give the benzoxazolinones (III) and the chloroacetamides (IV) which undergo condensation reaction in the presence of potassium hydroxide, producing the N‐carbamoylmethylbenzoxazolinones (V).
ChemInform Abstract: Synthesis and Recyclization of 4‐Chloromethylflavylium and 4‐Chloromethylbenzothiapyrylium Salts.
Authors: TOLKUNOV S. V. , DULENKO V. I.
Published: May 2016

Reaction of the α‐chloro‐o‐hydroxyacetophenones (I) with acetophenone (II) in the presence of perchloric acid in acetic acid gives the chloromethylflavylium salts (III), together with the 4‐methylflavylium salts (IV) as by‐products.
ChemInform Abstract: The (4 + 2) Cycloaddition of 1,6‐Dihydro‐2‐dimethylamino‐4,6,6‐trimethylpyrimidine with Acetylenic Compounds.
Authors: KASHIMA C. , SHIMIZU M. , OMOTE Y.
Published: May 2016

The dimethylaminodihydropyrimidine (I) reacts with the acetylenes (II) to give the dimethylaminopyridines (III).
ChemInform Abstract: Synthesis of 1,2,3,4‐Tetrahydro‐β‐carboline Derivatives as Hepatoprotective Agents. Part 1. Dithiocarbamates of Several α‐Amino Acids.
Authors: SAIGA Y. , IIJIMA I. , ISHIDA A. , MIYAGISHIMA T. , OH‐ISHI T. , MATSUMOTO M. , MATSUOKA Y.
Published: May 2016

The (hetero)cyclic α‐amino acids (I) are converted into the methyl dithiocarbamates (IV) by treatment with CS2 (II) and subsequent alkylation with methyl iodide (III).
ChemInform Abstract: Condensed Pyridazines. Part 6. Reaction of 7‐(Methylsulfonyl)‐1‐phenyl‐ 1H‐1,2,3‐triazolo(4,5‐d)pyridazine with Carbanions and Enamines.
Authors: OISHI E. , YAMADA A. , HAYASHI E. , HIGASHINO T.
Published: May 2016

Reaction of the triazolopyridazines (I) with the activated methylene compounds (II) in the presence of NaH gives the alkylated pyridazines (III).
ChemInform Abstract: Synthesis of 2‐Ethoxycarbonylbenzofuran Derivatives.
Authors: PREWYSZ‐KWINTO A.
Published: May 2016

Starting with the methylethoxycarbonylbenzofuran (I), the dialdehyde (VI) is prepared via a sequence of oxidation and reduction reactions.
ChemInform Abstract: Reactions of Monoesters of Ethylene Glycol with N,N‐Diethyl‐ 1,1,2,3,3,3‐hexafluoropropylamine.
Authors: WATANABE S. , FUJITA S. , SAKAMOTO M. , KURAMOCHI T. , KITAZUME T.
Published: May 2016

Reaction of the ethylene glycol monoesters (I) with 1,1,2,3,3,3‐hexafluoropropyldiethylamine (PPDA) (II) yields mixtures of the corresponding monofluorides (III) and the tetrafluoropropionates (IV).
ChemInform Abstract: Phosphorylation of Allylic Hydroxy Groups via Phosphite Intermediates.
Authors: SHADID B. R. , VAN DER PLAS H. C. , DE VROOM E. , VAN DER MAREL G. A. , VAN BOOM J. H.
Published: May 2016

In order to circumvent problems with the separation from byproducts or deblocking in phosphorylation reactions, (II) is phophitylated by salicylchlorophosphite (I).
ChemInform Abstract: Synthesis of Novel Crown Derivatives Incorporating a Diaminophosphine Group in a Polyether Macrocycle.
Authors: DUTASTA J. P. , SIMON P.
Published: May 2016

2‐Nitrophenol (I) is coupled with the polyethylene glycol ditosylates (II) and then reduced to give the o‐aminophenyl ethers (III).
ChemInform Abstract: Fluoro‐Containing Coordination Compounds of Chromium(III). Part 5. Preparation and Crystal Structure of the Racemic cis‐(Cr(en)2F2)ClO4·NaClO4·H2O.
Authors: BRENCIC J. V. , LEBAN I. , POLANC I.
Published: May 2016

The octahedral title complex is obtained from the saturated solutions of both cis‐(Cr(en)2F2) (Cr(en)2F4) and NaClO4 in water (yield about 20%).
ChemInform Abstract: Cluster‐Assisted Formation and Cleavage of C‐H and C‐C Bonds. (Fe3(CO)9(CCO))2‐ and Its Acetylide and Alkyne Derivatives.
Authors: HRILJAC J. A. , SHRIVER D. F.
Published: May 2016

The ketenylidene cluster (I) is acetylated or ethylated at the ketenylidene O atom to generate the anionic acetylide clusters (IIIa) and (IIIb).
ChemInform Abstract: Annelides. Part 23. Energy Transfer in Solid Phases of Octasubstituted Phthalocyanine Derivatives.
Authors: BLANZAT B. , BARTHOU C. , TERCIER N. , ANDRE J.‐J. , SIMON J.
Published: May 2016

The luminescence properties of solid solutions of (Ib) incorporated into (Ia) (0.05%‐16%) are studied.
ChemInform Abstract: A Rhodopsin Pigment Containing a Spin‐Labeled Retinal.
Authors: RENK G. E. , OR Y. S. , CROUCH R. K.
Published: May 2016

The two consecutive Wittig reactions of (II) and (IV) lead to the 9‐cis spin‐labeled retinal of type (V) accompanied by the di‐cis, 13‐cis, and all‐trans isomers.
ChemInform Abstract: A General Approach to the Synthesis of 2,3‐Di‐O‐Protected Derivatives of D‐Glyceraldehyde.
Authors: JURCZAK J. , BAUER T. , CHMIELEWSKI M.
Published: May 2016

Di‐O‐isopropylidenemannitol (Ia) is transformed into 3,4‐di‐O‐benzylmannitol (II) via (Ib).
ChemInform Abstract: The Influence of Potassium Iodate on Hydrogen Peroxide Decomposition in Bray‐Liebhafsky Reaction.
Authors: ANIC S. , KOLAR‐ANIC LJ.
Published: May 2016

The overall decomposition of H2O2 in the presence of KIO3 and H2SO4 is found to obey first order kinetics, not only with respect to H2O2, but also with respect to KIO3.
ChemInform Abstract: Kinetics and Mechanism of the Base Decomposition of Nitrogen Trichloride in Aqueous Solution.
Authors: KUMAR K. , SHINNESS R. W. , MARGERUM D. W.
Published: May 2016

The kinetics of decomposition of NCl3 in neutral and basic solutions is investigated in the presence of several different buffers and in the presence of excess hydroxide ion (up to 0.25 M).
ChemInform Abstract: LiTiCl3: Synthesis and Thermal Behavior.
Authors: MEYER G. , SCHLEID T. , SCHMIDT H.
Published: May 2016

The title compound, which is extracted for their simplicity from an expanded solid solution (Li24‐2nTinCl24; ∼ 4 ≤ n ≤ 10), has been prepared by synproportionation of TiCl3 and Ti in the presence of LiCl (2:1:3, 750 °C, sealed Ta tube).
ChemInform Abstract: Vibronic Absorption Spectra of Naturally Occurring Conjugated Polyenynes. Evidence for Localized Excitations.
Authors: SMULEVICH G. , MARZOCCHI M. P. , VINCIERI F. F. , CORAN S. A. , BAMBAGIOTTI ALBERTI M.
Published: May 2016

Normal and second‐derivative UV spectra, in hexane, are recorded for 13 polyunsaturated pentadecanes, all extracted from Oenanthe aquatica fruits as described previously.
ChemInform Abstract: Metal Ion Size Selectivity of 1‐Thia‐4,7‐diazacyclononane (9‐aneN2S), and Other Tridentate Macrocycles. A Study by Molecular Mechanics Calculation, Structure Determination, and Formation Constant Determination of Complexes of 9‐aneN2S.
Authors: HANCOCK R. D. , DOBSON S. M. , BOEYENS J. C. A.
Published: May 2016

Several aspects of the coordination chemistry of the tridentate cyclononane type macrocycles (I) and (II) are examined using molecular mechanics calculations, crystallography and formation constant determinations.
ChemInform Abstract: Palladium(0)‐Catalyzed Cycloaddition of Activated Vinylcyclopropanes with Aryl Isocyanates.
Authors: YAMAMOTO K. , ISHIDA T. , TSUJI J.
Published: May 2016

The unsaturated dicarbonates (I) react with dimethyl malonate (II) in the presence of a Pd(0) catalyst to give the products (III) which are cyclized, forming the vinylcyclopropanes (IV).
ChemInform Abstract: The Allylic Rearrangement. Part 5. Reaction of 4‐Haloisophorone with Sodium Methoxide in Methanol.
Authors: TSUBOI S. , KURIHARA Y. , WATANABE T. , TAKEDA A.
Published: May 2016

Isophorone (I) is converted to the chloro and bromo derivatives (III) by treatment with the N‐halosuccinimides (II).
ChemInform Abstract: Liquid‐Crystalline Solvents as Mechanistic Probes. Part 27. Control of Norrish II Reactions of 2‐ and sym‐Alkanones by the Ordered Solid Phases of Heneicosane.
Authors: NUNEZ A. , WEISS R. G.
Published: May 2016

In order to study if solvent order enhances the population of one conformer of the immediate precursors to the elimination products (II) + (III) and diastereomeric cyclization products (IV) (i.e.
ChemInform Abstract: Structural Studies on Bioactive Compounds. Part 6. Determination of the Sites of Protonation on Three 2,4‐Diaminopyrimidines of Pharmaceutical Importance by Proton‐Coupled 13C and 1H NMR Spectroscopy.
Authors: THREADGILL M. D. , GRIFFIN R. J. , STEVENS M. F. G. , WONG S. K.
Published: May 2016

The protonation of three 2,4‐diaminopyrimidines (I) of interest as antitumor agents has been studied by proton‐coupled 13C NMR and by 1H NMR spectroscopy in solution in DMSO.
ChemInform Abstract: tBuCl‐NaI as a Reagent for the Selective Reduction of Olefinic Double Bond of β‐Phenyl α,β‐Unsaturated Carbonyl Compounds.
Authors: SAKAI T. , MIYATA K. , HONDO K. , UTAKA M. , TAKEDA A.
Published: May 2016

Under the reaction conditions shown in the scheme, the unsaturated carbonyl compounds (Ia)‐(Id) are reduced to the corresponding saturated derivatives (IIa)‐(IId).
ChemInform Abstract: Reduction of gem‐Dibromocyclopropanes with Dialkyl Phosphonate and Amine.
Authors: HIRAO T. , MASUNAGA T. , HAYASHI K. , OHSHIRO Y.
Published: May 2016

The dialkyl phosphonates (II) are employed in the reduction debromination of the bicyclic geminal dibromide (I) to give mixtures of the endo‐ and exo‐bromides (III).
ChemInform Abstract: Selective Acylation of Amines by S‐Acyl Se‐Phenyl Selenosulfides.
Authors: TORU T. , YAMADA Y. , OSHIMA T. , IMAO S. , MAEKAWA E.
Published: May 2016

The S‐acyl‐Se‐phenyl selenosulfides (III), prepared from the thiocarboxylic acids (I) and N‐phenylselenenyl phthalimide (II), are employed in the acylation of the amines (IV).
ChemInform Abstract: Synthesis of α,β‐Unsaturated Carboxamides Using Dialkyltelluronium Carbamoylmethylide.
Authors: OSUKA A. , HANASAKI Y. , SUZUKI H.
Published: May 2016

The aldehydes (I) are coupled with the telluronium carbamoylmethylide (II) to form the α,β‐unsaturated carboxamides (III).
ChemInform Abstract: Nucleophilic Substitution of Aromatic Halides with Amines Under High Pressure.
Authors: IBATA T. , ISOGAMI Y. , TOYODA J.
Published: May 2016

The p‐nitrohalobenzenes (I) are aminated with the primary or secondary amines (II) under high pressure to form the nitroanilines (III).
ChemInform Abstract: A One‐Pot Transformation of Ketones into N‐(Meth)acryloyl‐2‐amino Acids.
Authors: HEILMANN S. M. , JENSEN K. M. , KREPSKI L. R. , MOREN D. M. , RASMUSSEN J. K. , SMITH H. K. II
Published: May 2016

The carbonyl compounds (I) are converted to the α‐amino nitriles (III) which are directly coupled with the acryloyl chlorides (IV) to produce the acrylamido nitriles (V).
ChemInform Abstract: Synthesis of Oxiranes by Using Sulfides‐Sulfonium Salts as Mediators.
Authors: FURUKAWA N. , OKANO K. , FUJIHARA H.
Published: May 2016

Benzaldehyde (I) reacts with benzyl bromide (II) in the presence of sulfides and alkali hydroxide to form the diphenyloxirane (III).
ChemInform Abstract: Stereoselective Synthesis of N‐Alkenyl Lactams.
Authors: ZEZZA C. A. , SMITH M. B.
Published: May 2016

The lactams (I) are coupled with the aldehydes (II) in the presence of p‐toluenesulfonic acid to produce the N‐alkenyl lactams (III) ‐ (V).
ChemInform Abstract: Reaction of Azoles with Ethyl Bromopyruvate Oxime: Alkylation by Substitution and by Elimination‐Addition.
Authors: GILCHRIST T. L. , STRETCH W. , CHRYSTAL E. J. T.
Published: May 2016

Imidazole (I) reacts with the oxime (II) to give the monoalkylation product (III) and the zwitterion (IV).
ChemInform Abstract: A Convenient Synthesis of 1H‐1,2,4‐Triazol‐1‐ylpropan‐3‐one Derivatives by Modified Mannich Reaction.
Authors: TAKAHASHI K. , SHIMIZU S. , OGATA M.
Published: May 2016

The substituted methyl ketones (Ia) ‐ (Ie) react with tetramethyldiaminomethane (II) in hot acetic anhydride to form the α‐methylene ketones (III) which are coupled with the azoles (IV), producing the β‐imidazolyl or β‐triazolyl ketones (Va) ‐ (Ve).
ChemInform Abstract: Synthesis of Some New Oxazoloquinolines and Styryloxazoloquinolines.
Authors: YANNI A. S. , HAMMAM A. S. , KHALIL Z. H. , KHALAF A. A. , ABDEL‐HAFEZ A. A.
Published: May 2016

The aminohydroxyquinoline (I) undergoes cyclocondensation with the aromatic aldehydes (II) in the presence of piperidine, yielding the oxazoloquinolines (III).