bluuebunny/crossref_metadata_2025 huggingface dataset:
Presynaptic Interactions between Trigeminal and Cervical Nociceptive Afferents Supplying Upper Cervical Lamina I Neurons
Authors: Fernandes Elisabete C. , Carlos-Ferreira José , Luz Liliana L. , Safronov Boris V.
Published: March 2022

Cervical and trigeminal afferents innervate neighboring cranial territories, and their convergence on upper cervical dorsal horn neurons provides a potential substrate for pain referral in primary headache syndromes. Lamina I neurons are central to this mechanism, as they relay convergent nociceptive input to supraspinal pain centers. Unfortunately, little is known about the interactions between trigeminal and cervical afferents supplying Lamina I neurons. Here, we used rats of both sexes to show that cervical and trigeminal afferents interact via presynaptic inhibition, where monosynaptic inputs to Lamina I neurons undergo unidirectional as well as reciprocal presynaptic control. This means that afferent-driven presynaptic inhibition shapes the way trigeminal and cervical Aδ-fiber and C-fiber input reaches Lamina I projection neurons (PNs) and local-circuit neurons (LCNs). We propose that this inhibition provides a feedforward control of excitatory drive to Lamina I neurons that regulates their convergent and cervical-specific or trigeminal-specific processing modes. As a consequence, disruption of the trigeminal and cervical afferent-driven presynaptic inhibition may contribute to development of primary headache syndromes.

SIGNIFICANCE STATEMENTCervical and trigeminal afferents innervate neighboring cranial territories, and their convergence on upper cervical dorsal horn neurons provides a potential substrate for pain referral in primary headache syndromes. Lamina I neurons are central to this mechanism as they relay convergent nociceptive input to supraspinal pain centers. Here, we show that cervical and trigeminal afferents interact via presynaptic inhibition, where inputs to Lamina I neurons undergo unidirectional as well as reciprocal control. The afferent-driven presynaptic inhibition shapes the trigeminocervical Aδ-fiber and C-fiber input to Lamina I neurons. This inhibition provides control of excitatory drive to Lamina I neurons that regulates their convergent and cervical-specific or trigeminal-specific processing modes. Disruption of this control may contribute to development of primary headache syndromes.
Re-analysing the Data From Moffatt et al. (2020): What Can We Learn From an Under-powered Absence of Difference?
Authors: Nalborczyk Ladislas
Published: March 2022

Moffatt et al. (2020) reported the results of an experiment (N = 26 in the final sample) comparing the facial electromyographic correlates of mental rumination and distraction, following an experimentally induced stressor. Based on the absence of significant difference (and BFs between 3.6 and 4.3) in the perioral muscular activity between the rumination and distraction conditions, Moffatt et al. (2020) concluded that self-reported inner experience was unrelated to peripheral muscular activity as assessed using surface electromyography. In this short commentary, we show that there is limited evidence for the main conclusion put forward by Moffatt et al. (2020), and we suggest ways forward, both from a theoretical and a methodological perspective. Complete source code, reproducible analyses, and figures are available at https://osf.io/ba3gk/.
Sample Size Justification
Authors: Lakens Daniël
Published: March 2022

An important step when designing an empirical study is to justify the sample size that will be collected. The key aim of a sample size justification for such studies is to explain how the collected data is expected to provide valuable information given the inferential goals of the researcher. In this overview article six approaches are discussed to justify the sample size in a quantitative empirical study: 1) collecting data from (almost) the entire population, 2) choosing a sample size based on resource constraints, 3) performing an a-priori power analysis, 4) planning for a desired accuracy, 5) using heuristics, or 6) explicitly acknowledging the absence of a justification. An important question to consider when justifying sample sizes is which effect sizes are deemed interesting, and the extent to which the data that is collected informs inferences about these effect sizes. Depending on the sample size justification chosen, researchers could consider 1) what the smallest effect size of interest is, 2) which minimal effect size will be statistically significant, 3) which effect sizes they expect (and what they base these expectations on), 4) which effect sizes would be rejected based on a confidence interval around the effect size, 5) which ranges of effects a study has sufficient power to detect based on a sensitivity power analysis, and 6) which effect sizes are expected in a specific research area. Researchers can use the guidelines presented in this article, for example by using the interactive form in the accompanying online Shiny app, to improve their sample size justification, and hopefully, align the informational value of a study with their inferential goals.
Ascent of Humans: Investigating Methodological and Ethical Concerns About the Measurement
Authors: Izydorczak Kamil , Grzyb Tomasz , Dolinski Dariusz
Published: March 2022

In this pre-registered study on a representative Polish sample (n = 1751), we aimed to test two potential critical issues with the Ascent of Humans scale. First, we tested whether the scores may be influenced by peripheral and previously undiscussed properties of the measurement: position of the slider-scale dot and the pattern of groups’ display. Second, we tested whether participation in Ascent of Humans measurement may influence the attitudes towards out-groups, making participants more prejudiced. All our predictions were conclusively disconfirmed. Additionally, we explored the distribution of Ascent of Humans, discovering large inflation of scores indicating the absence of dehumanisation. We discuss implications of our findings for improving theoretical grounds of dehumanisation and its measurement.
COUNTERMEASURES OF NEGATIVE EXTERNALITY THROUGH THE UTILIZATION OF USED GOODS FOR LIVE PHARMACIES
Authors: Marpaung Grace Natalia , Bowo Prasetyo Ari , Suseno Deky Aji , Putri Phany Ineke , Kumala Sepviana Nur
Published: March 2022

Kemiskinan merupakan permasalahan yang sering terjadi di Indonesia, tidak terkecuali di Kabupaten Batang, Jawa Tengah. Berdasarkan data pada Badan Pusat Statistik (BPS) Kabupaten Batang jumlah penduduk miskin di Kabupaten Batang pada tahun 2019 sebesar 64,07 ribu jiwa. Dalam mengatasi masalah-masalah yang terjadi, tim pengabdian memberikan beberapa solusi untuk membantu mengurangi permasalahan tersebut. Solusi yang ditawarkan tim pengabdian yaitu Pemanfaatan Sampah Botol Plastik Menjadi Apotek Hidup yang Memiliki Daya Jual. Pemanfaatan sampah botol plastik tersebut dapat mengurangi dampak eksternalitas negative dari banyaknya sampah yang menumpuk dan juga dapat memiliki daya jual sehingga dapat meningkatkan pendapatan masyarakat.  Tim memilih satu desa sebagai tempat untuk mengimplementasikan solusi tersebut yaitu desa Lobang. Tahapan dari metode yang dilakukan yaitu: 1. Persiapan, 2. Pelaksanaan, 3. Evaluasi dan pendampingan

 

Poverty is a common problem in Indonesia, no exception in Batang Regency, Central Java. Based on data from the Central Statistics Agency (BPS) Batang regency the number of poor people in Batang Regency in 2019 amounted to 64.07 thousand people. In addressing the problems, the service team provided several solutions to help reduce the problem. The solution offered by the service team is Utilization of Plastic Bottle Waste into a Living Pharmacy that Has Selling Power. The utilization of plastic bottle waste can reduce the negative externality impact of the amount of waste that accumulates and can also have selling power so as to increase people's income.  The team chose one village as the place to implement the solution, namely Lobang village. Stages of the method are: 1. Preparation, 2. Implementation, 3. Evaluation and assistance.
OPTIMIZATION OF OUTCOME PROGRAM VOCATIONAL LONG-LIFE EDUCATION “PKBM BINA WARGA KENDAL” THROUGH THE DEVELOPMENT OF ENTREPRENEURIAL-BASED WEBSITE
Authors: Kardoyo Kardoyo , Feriady Muhammad , Farliana Nina , Pitaloka Lola Kurnia
Published: March 2022

Vocational Education Package C program implemented by PKBM Bina Warga Kab. Kendal has been proven to have excellent entrepreneurial spirit outcomes. However, there are still major shortcomings in the field of blended learning-based education management. This article describes the picture of the completion of non-formal entrepreneurial learning solutions that are very important to open new jobs. The concept of vocational long-life education is intended as an equality-based education at the level organized by PKBM Bina Warga Kendal. The method of devotion carried out to alleviate the solution is to provide a series of Entrepreneurial Web-based training activities, namely learning websites as well as a web marketing for entrepreneurial training products. The result of the devotion carried out is a new pattern in conducting entrepreneurship and marketing training compared to before the activity was carried out. The new pattern is the existence of digital marketing learning as well as strengthening the character of entrepreneurship through technology. The advice that can be given after the implementation of devotion is the existence of digital marketing training as a strengthening of entrepreneurship in the field of marketing using existing websites and other platforms.

Program Paket C Pendidikan Vokasi yang dilaksanakan oleh PKBM Bina Warga Kabupaten Kendal sudah terbukti memiliki outcome jiwa wirausaha yang sangat baik. Akan tetapi masih terdapat kekurangan utamanya dalam bidang pengelolaan pendidikan berbasis Blended learning. Artikel ini menjelaskan gambaran penyelesaian solusi pembelajaran kewirausahaan non formal yang sangat penting dalam rangka membuka lapangan pekerjaan baru. Konsep vocational long-life education dimaksudkan sebagai pendidikan berbasis kesetaraan dalam jenjang yang diselenggarakan oleh PKBM Bina Warga Kendal. Adapun metode pengabdian yang dilakukan untuk mengentaskan solusi tersebut adalah dengan memberikan serangkaian kegiatan pelatihan Entrepreneurial Web based, yaitu website pembelajaran sekaligus di dalamnya adalah web pemasaran untuk produk hasil pelatihan kewirausahaan. Hasil dari pengabdian yang dilakukan adalah adanya pola baru dalam melakukan pelatihan kewirausahaan dan pemasaran dibandingkan sebelum kegiatan dilaksanakan. Pola baru tersebut adalah adanya pembelajaran digital marketing sekaligus penguatan karakter kewirausahaan melalui teknologi. Adapun saran yang bisa diberikan pasca pelaksanaan pengabdian adalah adanya pelatihan digital marketing sebagai penguatan kewirausahaan dalam bidang pemasaran menggunakan Website yang sudah ada maupun platform lainnya.
ASSISTANCE OF MSMES OF GENDONGAN VILLAGE, TINGKIR SUBDISTRICT, SALATIGA CITY, THROUGH DIGITAL MARKETING
Authors: Widyakto Adhi , Suryawardana Edy , Susanto Susanto
Published: March 2022

The purpose of this community service activity is to help increase sales for MSMEs in Gendongan Village who are affected by the COVID 19 pandemic. With this pandemic condition, MSMEs are required to survive to avoid bankruptcy. The method used in this community service activity provides direct Training with tutorials in the field by teaching how to apply digital marketing or online marketing. The expected result is that the MSME product market in Gedongan Village gets a broader market reach, of course, with recognizable and easily accessible products by consumers.

Tujuan kegiatan pengabdian masyarakat ini yaitu untuk membantu meningkatkan penjualan bagi UMKM di Kelurahan Gendongan yang terdampak pandemi COVID 19. Dengan adanya kondisi pandemi ini maka UMKM di tuntut untuk bertahan agar terhindar dari kebangkrutan. Metode yang digunakan dalam kegiatan pengabdian kepada masyarakat ini yaitu dengan memberikan pelatihan secara langsung dengan tutorial di lapangan dengan mengajarkan cara menerapkan digital marketing atau pemasaran online. Hasil yang diharapkan yaitu pasar produk UMKM di Kelurahan Gedongan mendapatkan jangkauan pasar yang lebih luas tentunya dengan produk yang dikenali dan mudah di akses oleh konsumen.
A suppressor of dioxygenase inhibition in a yeast model of SDH deficiency
Authors: Beimers William , Braun Megan , Schwinefus Kaleb , Pearson Keenan , Wilbanks Brandon , Maher Louis James
Published: March 2022

A fascinating class of familial paraganglioma (PGL) neuroendocrine tumors is driven by the loss of the tricarboxylic acid (TCA) cycle enzyme succinate dehydrogenase (SDH) resulting in succinate accumulation as an oncometabolite and other metabolic derangements. Here, we exploit a Saccharomyces cerevisiae yeast model of SDH loss where accumulating succinate, and possibly reactive oxygen species, poison a dioxygenase enzyme required for sulfur scavenging. Using this model, we performed a chemical suppression screen for compounds that relieve dioxygenase inhibition. After testing 1280 pharmaceutically active compounds, we identified meclofenoxate HCl and its hydrolysis product, dimethylaminoethanol (DMAE), as suppressors of dioxygenase intoxication in SDH-loss yeast cells. We show that DMAE acts to alter metabolism so as to normalize the succinate:2-ketoglutarate ratio, improving dioxygenase function. This study raises the possibility that oncometabolite effects might be therapeutically suppressed by drugs that rewire metabolism to reduce the flux of carbon into pathological metabolic pathways.
Outcomes of Coronary Artery Disease Patients with Severe Left Ventricular Dysfunction Undergoing Surgical Management
Authors: Ponnuru Srawanthi , Radhakrishnan Bineesh K , Sudevan Remya , Karunakaran Jayakumar
Published: March 2022

Background: Surgical revascularization by coronary artery bypass grafting (CABG) is the gold standard treatment for coronary artery disease. But, in patients with severe left ventricular dysfunction (ischemic cardiomyopathy), the result of CABG is different from those with normal left ventricular function. The coronary artery disease pattern in the Indian subconti-nent is different from the western world, due to the diffuse nature of coronary involvement, the smaller size of native vessels, increased prevalence of diabetes mellitus and other risk factors, and more prevalence of severe left ventricular dysfunction. Most of the studies regarding the surgical outcomes in ischemic cardiomyopathy come from western countries. This study attempts to assess the outcomes of surgical management of ischemic cardiomyopathy in the Indian subcontinent.
Methods: A single-center retrospective cohort study was conducted at Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram. The data of CAD pa-tients, who underwent surgical coronary revascularization for severe LV dysfunction from January 2010 to December 2014, were collected from the hospital records and through tele-phonic interviews in a structured study proforma. A total of 146 patients satisfied the criteria and were followed up for a period of 5 years.
Results: The mean age of the study population was 55.6 (8.8) years. Male preponderance was observed (94.52%; N = 138). CABG alone was done in 62.3% (N = 91) of the study partici-pants. CABG with linear plication was done in 23.3% (N = 34), CABG with MV repair in 7.5% (N = 11), and CABG with DORS in 6.8% (N = 10). The majority of patients (N = 54, 37%) received 4 grafts. Thirty-day mortality observed in the study population was 11 (7.5%). The causes documented were cardiac causes in 9 (82%), cerebrovascular events in one (9%), and septicemia in one (9%). The mean of 5-year survival of the study population was 94.2 (3.5) months with 95% CI 87.32, 101.13. There was a substantial improvement in the degree of mitral regurgitation. Ejection fraction (EF) also showed improvement. The mean preoperative EF was 29.51 (4.84%) and that of post-op was 39.92 (9.0%).
Conclusion: Despite the challenges of diffusely diseased coronary arteries, severe LV dysfunction, addressing associated significant MR and ventricular aneurysms, the outcome of surgical management of CAD with severe LV dysfunction, in the Indian population can be done with acceptable results. Randomized control studies in this subset can provide more solid evidence in this regard.
Una revisión de alcance sobre las relaciones entre vínculos sexo-afectivos y tecnologías digitales
Authors: Zapata Isis , Vargas Juana , Marín-Cortés Andrés
Published: March 2022

Este artículo presenta los resultados de una revisión de alcance (scoping review) sobre investigaciones que establecen relaciones entre los vínculos sexo-afectivos y el uso de tecnologías digitales, publicadas en castellano y en revistas científicas de Iberoamérica entre 2009 y 2019. La búsqueda se realizó en las bases de datos Dialnet, Psyarticles, Redalyc, Scielo, Science Direct, Scopus y Web of Science (WOS). Luego de aplicar los criterios de inclusión y exclusión a las 579 citaciones encontradas inicialmente, se conformó una muestra final de 23 artículos. Los hallazgos indican que las investigaciones se ocupan principalmente de cuatro temas: 1) los significados sobre el uso de dating apps; 2) los fenómenos digitales relacionados con los vínculos sexo-afectivos; 3) el sexting; y 4) la violencia entre parejas en Internet. La construcción de vínculos sexo-afectivos por medio de tecnologías digitales se vale de fenómenos psicosociales como la auto-presentación online, la desinhibición online y la comunicación asincrónica.
Ayudar y recibir ayuda de otros: precisiones sobre la regulación emocional interpersonal
Authors: Gómez-Rivera Yuri Bibiana , Acosta-Silva David Arturo
Published: March 2022

Se discuten algunos elementos de la regulación emocional interpersonal con el objetivo de sintetizar y organizar las contribuciones teóricas y empíricas que se han generado sobre el tema. Se presenta cómo se ha analizado la regulación emocional desde el surgimiento de estos estudios en los noventa, describiendo características, procesos, clases, motivos, elementos y consecuencias de la regulación emocional interpersonal que ha reportado la literatura. Se concluye presentando algunas limitaciones que a nuestro juicio ha tenido la regulación emocional interpersonal: su falta de consenso teórico entre investigadores, su escasa investigación en diversas áreas del conocimiento (como en la educación), su incipiente exploración en el contexto latinoamericano y la carencia de su estudio con niños, niñas y adolescentes; estas limitantes pueden servir para superar los vacíos teóricos y motivar a futuros investigadores a colaborar en la producción investigativa de este campo.
De la resistencia a la transformación: una revisión de la resiliencia en el deporte
Authors: Jaramillo-Moreno Ricado A. , Rueda Cantor Julio Cesar
Published: March 2022

Se realizó una revisión de literatura acerca de los aportes investigativos de la resiliencia en el deporte entre los años de 2010 y 2020 en una muestra de 239 artículos, que respondieron a criterios de inclusión como: artículos originales, de revisión de literatura, estudios cualitativos, cuantitativos o mixtos publicados; tesis o trabajos de grado y capítulos de libro. La búsqueda se realizó en las Bases de Datos: PubMed, Ebsco Host, Science Direct, Scopus, PsyINFO. Se halló que la investigación y aportes de la resiliencia en el deporte son numerosos y aplicados a una gran diversidad de modalidades deportivas y a nivel de actividad física, deporte formativo y competitivo. Se encontraron predominantemente estudios cuantitativo-descriptivos; sin embargo se destacan diversos enfoques metodológicos. Se observó además que los estudios se orientaron hacia las poblaciones de adultos y adolescentes, y un tercer foco de interés son las revisiones de literatura. Los campos en los que se exploró la resiliencia en el deporte se asociaron al desempeño en competencia, afrontamiento de la adversidad, situaciones estresantes, o de Burn Out, como dimensión motivacional. Se concluye que es necesario realizar estudios específicos por práctica deportiva, tipos de deporte y fenómenos psico-sociales relacionados como la influencia de la recuperación de lesiones, estados anímicos y situaciones adversas extradeportivas y extra-competición.
Atención y memoria en estudiantes de básica primaria de instituciones públicas rurales de Boyacá, Colombia
Authors: Jiménez-Martínez Martha , Nieto-Súa Dary Lucia , Manrique-Abril Fred
Published: March 2022

La atención y la memoria son procesos estrechamente relacionados y paralelos en el desarrollo infantil. Este estudio buscó establecer la relación entre procesos de atención y memoria en infantes de escuelas rurales respecto a la edad, sexo y nivel educativo. Se seleccionaron 50 estudiantes por muestreo aleatorio, dentro de un estudio descriptivo correlacional. Se utilizó la Evaluación Neuropsicológica Infantil. Los resultados mostraron diferencias significativas con respecto a la edad para las sub-pruebas de memoria y atención visual. En la variable sexo, no se encontraron diferencias significativas. Con relación al nivel de escolaridad las diferencias fueron para subpruebas de atención y memoria excepto en memoria lógica. En conclusión, se observó un menor rendimiento al compararlos con baremos de población urbana.
Working on video platforms: forms of development and organization of the activity of YouTube audiovisual producers in Argentina
Authors: Dolcemascolo Agostina
Published: March 2022

This paper focuses its analysis on how YouTube audiovisual content producers in Argentina develop and organize their activity, which they perceive as work. Specifically, it is interested in knowing whether they carry out their activity individually or collectively, and whether there is any form of collective organization (actual or potential) in the face of possible conflicts with the platform. To do this, a series of interviews conducted with producers during 2018 were analyzed. Additionally, the discourse of the video platform was studied to understand to what extend this corresponds to the producers’ narratives. The main findings account for a marked individuality in the ways of developing their activity, a fact that comes into collision with potential forms of collective organization and reproduces YouTube’s discourse.
El siglo XX dominicano en Colombia: propuesta de una periodización histórica
Authors: Correa Higuera Juan Francisco
Published: March 2022

En su biografía de Camilo Torres, el historiador Walter Broderick (1996) atribuye a la Orden de Predicadores el calificativo de oscurantista, y a sus miembros los rotula como ignorantes que viven de las prácticas supersticiosas de las clases más desfavorecidas del país. Esta aseveración sirve como pretexto para la introducción a un ejercicio de análisis histórico sobre la decadencia, desaparición y la subsiguiente restauración de la Orden de Predicadores en Colombia. Con ello se busca proponer una periodización de la historia de la Orden en el país durante el siglo XX. A partir de la confrontación de fuentes primarias y secundarias, se busca poner de relieve los juegos sociales y políticos que condujeron, simultáneamente, a la construcción de la república y a la decadencia de las órdenes religiosas en el país. Luego, de manera más extensa, se presentará el proceso de restauración de la Orden entre los años 1881 y 1965, a través de las tres etapas que se han podido identificar.
The new intellectual history versus the history of ideas: some critical simplifications
Authors: Pachón Soto Damian
Published: March 2022

This research article presents the criticisms that intellectual history, in its version of history of political languages, makes to the history of ideas. The background of both historiographies is presented and it analyzes how the criticism made by the intellectual history incurs in theoretical simplifications, where the history of ideas is reduced to the capture of the peculiarity and originality of ideas in Latin America, neglecting its political purposes, its commitment to the knowledge of the region and its commitment to decolonization and emancipation. It is argued that the type of analysis carried out by intellectual history questions the philosophical character and depoliticizes the history of ideas. It is concluded that, although the approach to the history of political languages allows the analysis of an interesting set of problems, it is not a matter of one historiographic model being replaced by another, but of the coexistence of epistemic and methodological pluralism. The methodology used for the research is textual hermeneutics.
Esporte da Polônia da “cortina de ferro”
Authors: Marques Junior Nelson Kautzner
Published: March 2022

O objetivo do artigo é descrever sobre a Polônia da “cortina de ferro” e a relação entre regime político e esporte. Entender como a Polônia foi formada e como ela se desenvolveu politicamente é importante para o leitor compreender como esse país tratou o esporte de alto rendimento no período da “cortina de ferro”. O esporte foi difundido no Reino da Polônia por meio do Sokol, sendo fundado em 1867. Nesse país, foram criados determinados jogos que se tornaram patrimônio cultural dessa nação. Essas modalidades eram o pieklo e niebo, o sztekiel, o stock, o piersaeniówka e o kulotko. Desde 1947, a Polônia adotou o regime político da União das Repúblicas Socialistas Soviéticas (URSS) e aplicou na sua população o sistema esportivo soviético. O jovem inciava a prática das modalidades na escola quando criança e era acompanhado até a fase adulta. Em conclusão, o esporte polonês atingiu sucesso competitivo porque seguiu a metodologia científica do treinamento esportivo da URSS.
On the consideration of the draft Program of the All-Ukrainian Population Census in 2023
Authors:   Ptoukha Institute for Demography and Social Studies of the National Academy of Sciences of Ukraine, Kyiv, Ukraine, Libanova Ella , Verner Ihor ,   State Statistics Service of Ukraine, Kyiv, Ukraine
Published: March 2022

The co-report states that real information on the number and composition of the country's population, which can only be provided by the census, is a necessary prerequisite for effective governance, formation and implementation of balanced social policy, forecasting further demographic changes. The information value of the census depends on the completeness of the list of questions on which the population is surveyed, their coordination with all interested ministries and agencies and compliance with international standards. Therefore, the task of academic science is to assist the State Statistics Service of Ukraine in formulating questions in the census questionnaire. At the joint meeting of the Presidium of the National Academy of Sciences of Ukraine and the Board of the State Statistics Service, the proposed draft Program of the All-Ukrainian Population Census, which is planned for 2023, was approved. This program contains more than 50 questions and defines a list of demographic and socio-economic characteristics of individuals, households and living conditions of population.
Double-acting anticancer drugs to overcome the acquired resistance of malignant cells to chemotherapy
Authors:   Institute of Cell Biology of National Academy of Sciences of Ukraine, Lviv, Ukraine, Panchuk Rostyslav
Published: March 2022

Molecular mechanisms underlying the unique ability of angucycline antibiotics of the landomycin family to overcome the acquired multi-drug resistance of tumor cells are studied. This phenomenon is shown to be based on the early induction of hydrogen peroxide in malignant cells without the involvement of mitochondria and the specific binding of these antibiotics to cellular thiols. It is demonstrated that early H2O2 generation by landomycins is mediated by NQO1 enzyme, and the use of its specific inhibitor (dicoumarol) significantly decreased both ROS production and cytotoxic activity of landomycins. Another mode of action of these anticancer antibiotics is tightly connected with their innate ability to bind to cellular thiols, thus leading to depletion of glutathione pool and subsequent induction of apoptosis. Cancer drug resistance is usually associated with increased cellular levels of glutathione, thus the increased affinity of landomycins for thiols may explain the selectivity of their action on drug-resistant tumor cells.
Cell Therapy in Heart Failure with Preserved Ejection Fraction
Authors: Frljak Sabina , Poglajen Gregor , Vrtovec Bojan
Published: March 2022

Heart failure with preserved ejection fraction (HFpEF) is the most common cause of hospitalisation for heart failure. However, only limited effective treatments are available. Recent evidence suggests that HFpEF may result from a systemic proinflammatory state, microvascular endothelial inflammation and microvascular rarefaction. Formation of new microvasculature in ischaemic tissues is dependent on CD34+ cells, which incorporate into the newly developing vasculature and produce pro-angiogenic cytokines. In HFpEF patients, worsening of diastolic function appears to correlate with decreased numbers of CD34+ cells. Therefore, it is plausible that increasing the myocardial numbers of CD34+ cells could theoretically lead to improved microvascular function and improved diastolic parameters in HFpEF. In accordance with this hypothesis, recent pilot clinical data suggest that CD34+ cell therapy may indeed be associated with improved diastolic function and better functional capacity in HFpEF patients and could thus represent a promising novel therapeutic modality for this patient population.
Deontology or consequentialism? Ethical approach on the use and management of wildlife, illustrated by the use of caimans in Latin America
Authors: Larriera Alejandro
Published: March 2022

Government decision-makers are frequently faced with the choice of enabling or maintaining conservation programs based on the sustainable use of wild species – usually beneficial to both human populations and the ecosystem - or adhering to the ethical or moral requirements of those who oppose the commercial use of animals. The purpose of this document is to discuss this conflicting situation.
The continuing decline in the populations of wild species, as well as the high commercial interest in them, promoted the establishment of Sustainable Use strategies in the mid-20th century, which resulted in significant population recovery of several species. However, a growing number of Non-Governmental Organizations (NGOs) deepened the combat against the exploitation of animals for human consumption in all forms, beginning in the early 21st century and intensifying in the second decade, based on alleged ethical principles, and claiming for compassion towards wild animals. In this context, it is currently very common to observe government officials tending to ban extractive activities, more often out of fear of condemnation in social networks than based on professional conviction. In the case of management of wild species, this approach is characterized by a lack of scientific basis, empathy with indigenous and rural communities, and of concrete alternative ideas to the modes of exploitation that have been developed so far.
A TDIC nos cursos de pedagogia da tríplice fronteira Brasil-Venezuela-Guyana
Authors: Targino Emerson Daniel de Souza , Camargo Leila Maria , Ferst Enia Maria
Published: March 2022

The work seeks to guide reflections on the discussion of Digital Information and Communication Technologies - TDIC - and the approach given to them in the Pedagogy curricula of two Higher Education Institutions located on the border with English Guyana and Venezuela, in the extreme north of the country. Brazil. With the Covid-19 pandemic, teachers around the world were taken by surprise because of the pandemic and challenged to totally change their routines and workspaces, reorienting their practices through the use of digital and remote technologies. Faced with the challenge posed, we focus on looking at this reality through the analysis of teacher training courses, having the state of Roraima-Brazil as a locus and asking the following questions: What are the possible challenges faced by future teachers in the use of TDIC in the territorial context of the Triple Border? What is the importance of training education professionals from the perspective of TDIC? This is a qualitative, documentary and exploratory research, focusing on the curriculum of two undergraduate courses in Pedagogy at public institutions, especially the disciplines that propose to discuss TDICs. As preliminary results, in general, it was possible to verify that both institutions seek to adapt within the possibilities that the moment demanded in terms of remote technologies in the curricula of the mentioned courses. However, there is still a long way to go towards the necessary ethical discussions regarding the other dimensions of technologies that are in need of a more critical debate.
Pengembangan Modul Pembelajaran Matematika Berbasis Realistic Mathematic Education pada Materi Sistem Persamaan Linear
Authors: Sepriyanti Nana , Nuri Latifa
Published: March 2022

The purposes of this research are: 1) Generate math learning modules based RME valid criteria; and 2) Generate RME-based math learning modules that meet practical criteria. Type of research used is research of development with 4D models that has been created by S. Thiagrajan (1974) consists of four development stages; define, design, develop, and disseminate. The research is only conducted until the third stage, i.e. developing stage. Defines stage consists of: a) the analysis beginning of the end; b) the analysis of learners; c) the analysis of concept; d) the analysis of task; and e) specification of learning objectives. Designs stage consists of: design of the mathematics module; b) design of instruments and instrument validation assesment learning devices. Develops stage consists of: a) validation module by expert and mathematics teacher; b) testing; c) questionnaire responses of teachers and students; d) interview with student. Result of the research indicates that based on the assessment of experts, this module have been valid with an average of 83,63%. Based on the result questionnaire responses of teachers, questionnaire responses of students, and interviews with students indicates this module have been very practical use on the learning of mathematics on material system of linear equations with an average 85,24% by teachers and 82,40% by students
Pengaruh Penerapan Model Pembelajaran Kooperatif Tipe Think Talk Write Terhadap Kemampuan Komunikasi Matematis Siswa Kelas XI IPA MAN Kota Padang
Authors: Irwan Irwan
Published: March 2022

This research was aimed at finding out (1) mathematical communication skills, and (2) mathematical communication skills of students based on high, medium, and low knowledge. This research is a quasiexperimental research. Sample of this research is students at XI IPA1 and XI IPA2 MAN Padang. The accumulation of data using test and the analysis of data by statistical. The results showed that (1) mathematical communication skills of students who are taught by TTW better than conventional learning, (2) mathematical communication skills of students initial knowledge high, medium, and low are better taught by TTW than conventional learning
KEMAMPUAN PEMECAHAN MASALAH MATEMATIKA SISWA MENGGUNAKAN MODEL PEMBELAJARAN KOOPERATIF TIPE STAD
Authors: Mawaddah Nia Waziratul , Deswalantri Deswalantri , Fitri Haida
Published: March 2022

Rendahnya kemampuan pemecahan masalah matematika siswa kelas VIII MTsS Madinatul Munawwarah Bukittinggi dan model pembelajaran yang digunakan guru belum mampu memecahkan masalah tersebut, sehingga salah satu alternatif model pembelajaran yang dapat digunakan untuk mengatasinya adalah model pembelajaran kooperatif tipe STAD. Tujuan penelitian ini adalah untuk mengetahui kemampuan pemecahan masalah matematika siswa dengan model pembelajaran kooperatif tipe STAD lebih baik daripada kemampuan pemecahan masalah siswa dengan pembelajaran konvensional pada kelas VIII MTsS Madinatul Munawwarah Bukittinggi Tahun Pelajaran 2019/2020. Jenis penelitian ini adalah penelitian pra-eksperimen dengan rancangan penelitian The Static Group Comparison Design. Instrumen yang digunakan adalah tes kemampuan pemecahan masalah matematika. Data Data yang diperoleh dianalisis dengan menggunakan uji t. Hasil penelitian ini menyatakan bahwa kemampuan pemecahan masalah matematika siswa dengan model pembelajaran kooperatif tipe STAD lebih baik daripada kemampuan pemecahan masalah mateatika siswa dengan pembelajaran konvensional pada kelas VIII MTsS Madinatul Munawwarah Bukittinggi Tahun Pelajaran 2019/2020.
ETNOMATEMATIKA PADA ALAT MUSIK GAMELAN JAWA
Authors: Supriyono Supriyono , Purwaningsih Wharyanti Ika , Saputra Agil Faisal
Published: March 2022

This study aims to determine the mathematical concepts applied to Javanese gamelan musical instruments. The type of research used in this research is qualitative research with an ethnographic approach, namely describing Javanese gamelan musical instruments as a medium for learning Mathematics. Data obtained through interviews, observation, and documentation. The instrument in this study consisted of the main instrument, namely the researcher himself and auxiliary instruments in the form of interview guidelines, observation sheets, and documentation tools. The data validity technique used is method triangulation and source triangulation. The results of this study indicate that there are mathematical concepts that are applied to Javanese gamelan musical instruments such as one-dimensional geometry, namely the concept of lines, parallel lines and right angles, two-dimensional geometry, namely square, rectangle, circle, trapezoid, and triangle. three in the form of a tube, a sphere, and a truncated cone. With the existence of mathematical concepts in Javanese gamelan musical instruments, it is very possible for mathematics learning media to be designed using Javanese gamelan ethnomathematics so that mathematics contributes to the preservation of the nation's culture.
PEMODELAN DATA SAHAM MENGGUNAKAN ANALISIS TIME SERIES DENGAN PENDEKATAN COPULA GAUSSIAN
Authors: Jannah Miftahul , Mardika Fitria , Hasibuan Lilis Harianti , Putri Darvi Mailisa
Published: March 2022

One method of predicting stock prices is to use the time series analysis method. In this method, a linear prediction model is made to see patterns from historical stock price data to assess future prices. The stock data used in this study is the daily stock data of PT. Telkom and PT. Indosat in 2020-2021. Autoregressive (AR) model is a time series model that is often used with the assumption that its volatility does not change with time (Homoscedastic). After analyzing the AR Model(1) data for the stock data of PT. Telkom and PT. Indosat has a non-independent error, therefore the AR(1)-N.GARCH(1,1) time series model construction was carried out to model the error (ϵ_(i,t)). Furthermore, the error of the AR(1)-N.GARCH(1,1) model is independent of t, so it can be modeled using Copula. After the Copula model was applied to the data and obtained the value of the fit of the Gaussian Copula distribution error model. From the values generated from the Gaussian Copula C({ϵ_(i,t) }_(t=1)^T ),T=1,2,…, and approximates a uniform distribution. So the stock data of PT. Telkom and PT. It can be said that Indosat is not suitable to be modeled with the Gaussian Copula.
PRAKTIKALITAS MEDIA PEMBELAJARAN MATEMATIKA BERBENTUK VIDEO SIMULASI PADA SISWA SEKOLAH MENENGAH KEJURUAN
Authors: Fitri Yuliani , Putri Anike
Published: March 2022

This study was conducted due to the lack of audi visual learning aids in developing students’ understanding on two-variable linear equation. The aim of this study is to describe the practicality of developed medium, specially, video of simulation for learning mathematics in TAV students of X grade of SMK 5 Padang concerning two-variable linear equation. This developing study uses procedural development in accordance to Alessi and Trollip (2001), consisting of 3 steps; planning; design; and development. Practicality data of product gained through development phase by scoring teacher responded questionnaire and student responded questionnaire. The result of product testing shows that video of simulation is pratical to be used in learning mathematics.
Effects of retrieval-extinction training on internet gaming disorder
Authors: Zhao Qian , Zhang Yongjun , Wang Min , Ren Jiecheng , Chen Yijun , Chen Xueli , Wei Zhengde , Sun Jingwu , Zhang Xiaochu
Published: March 2022

Background and aims

Internet gaming disorder (IGD) leads to serious impairments in cognitive functions, and lacks of effective treatments. Cue-induced craving is a hallmark feature of this disease and is associated with addictive memory elements. Memory retrieval-extinction manipulations could interfere with addictive memories and attenuate addictive syndromes, which might be a promising intervention for IGD. The aims of this study were to explore the effect of a memory retrieval-extinction manipulation on gaming cue-induced craving and reward processing in individuals with IGD.

Methods

A total of 49 individuals (mean age: 20.52 ± 1.58) with IGD underwent a memory retrieval-extinction training (RET) with a 10-min interval (R-10min-E, n = 24) or a RET with a 6-h interval (R-6h-E, n = 25) for two consecutive days. We assessed cue-induced craving pre- and post-RET, and at the 1- and 3-month follow-ups. The neural activities during reward processing were also assessed pre- and post-RET.

Results

Compared with the R-6h-E group, gaming cravings in individuals with IGD were significantly reduced after R-10min-E training at the 3-month follow-up (P < 0.05). Moreover, neural activities in the individuals with IGD were also altered after R-10min-E training, which was corroborated by enhanced reward processing, such as faster responses (P < 0.05) and stronger frontoparietal functional connectivity to monetary reward cues, while the R-6h-E training had no effects.

Discussion and Conclusions

The two-day R-10min-E training reduced addicts’ craving for Internet games, restored monetary reward processing in IGD individuals, and maintained long-term efficacy.
First records of Yellowbar King Angelfish, Pomacanthus maculosus (Forsskål, 1775) (Perciformes, Pomacanthidae), in the Tropical Eastern Pacific
Authors: Zavala Jiménez Aldo Alfonso
Published: March 2022

The first records are presented of Pomacanthus maculosus (Forsskål, 1775) in the Tropical Eastern Pacific. The natural range of this fish species extends from the Persian Gulf to the coast of East Africa. Two adults were recorded at Los Arcos de Mismaloya, México, one in June 2018 and another in September 2020, 1 km from the site of the first observation. This species was probably introduced into this area as an aquarium release due to proximity of the two sites to highly dense human population centers.
Borneodessus zetteli kalimantanensis Balke, Hendrich, Mazzoldi & Biström, 2002: first record of a rare and little-known diving beetle from Sarawak (Coleoptera, Dytiscidae)
Authors: Kodada Ján , Selnekovič Dávid , Balke Michael , Hendrich Lars
Published: March 2022

The diving beetle Borneodessus zetteli kalimantanensis Balke, Hendrich, Mazzoldi & Biström, 2002, an endemic species of Borneo, is recorded for the first time from Sarawak. The specimen was collected from submerged rootlets of a large shore tree from the Pa’ Ngaruren River (Kelabit Highland, Sarawak) with Neptosternus kodadai Hendrich & Balke, 1997 and N. quadrimaculatus Hendrich & Balke, 1997. Two species of the genus Elmomorphus Sharp, 1881, Stenomystax minutus Kodada, Jäch & Čiampor, 2003, and S. depressus Kodada, Jäch & Čiampor, 2003 shared the same microhabitat. 
On the issue of pathogenesis of placental dysfunction in women with miscarriage
Authors:   SHEI Ivano-Frankivsk National Medical University, Rymarchuk M.І. , Cheredarchuk A.R. ,   SHEI Ivano-Frankivsk National Medical University, Gibson Okoloch Onieca ,   SHEI Ivano-Frankivsk National Medical University
Published: March 2022

To determine the correlation of local non-progressive abruption of placenta and the development of placental dysfunction with undifferentiated connective tissue dysplasia (UCTD), we have conducted the case-consequence research with 100 patients. The research included two stages. At the first stage, all the predictors of this complication were divided into 4 groups: somatic anamnesis, obstetric, gynecological and infectious anamnesis, course of the given pregnancy and results of tests for Phase-II detoxification gene polymorphism. At the second stage, all the significant predictors were included in a multifaceted logistic regressive analysis. The most significant causes of local non-progressive abruption of placenta at placental dysfunction are the following: UCTD (OR-18.86; 6.58–54.02), its visceral markers such as scoliosis (OR 5.76; 2.08–15.97), heart diseases (mitral valve prolapse, hypertensive neurocirculatory dystonia, supplemental chord) (OR 8.61; 3.11–23.83), myopia (OR 6.25; 2.26–17.29), platypodia (OR 4.49; 1.61–12.55), renal diseases (OR 7.94; 2.87–21.98). The sheer presence of UCTD in this category of patients increases by 18 times the risk of disorder of trophoblast invasion and development of placental dysfunction. Key words: local placental abruption, undifferentiated connective tissue dysplasia, placental dysfunction, gene polymorphism.
Results of controlled stimulation of ovulation in patients with tuboperitoneal infertility depending on the drug used
Authors:   Medical Center Mother and Child, Kyiv, Bagatko O.V.
Published: March 2022

The objective: was to study the effectiveness of stimulation of ovulation in women with tuboperitoneal infertility, depending on the drug used. Materials and methods. To achieve this goal, 239 patients with tuboperitoneal infertility were examined, which were randomly divided into two groups I (main, n=118) and II (comparisons, n=121). Women of the main group for KOS were prescribed a single subcutaneous injection of corypholitropin alfa into the abdominal wall at the beginning of the follicular phase of the menstrual cycle at a dose of 150 μg. Women in the comparison group received daily injections of follitropin beta 150–225 IU for 6–12 days. After denudation the maturity and quality of the eggs was evaluated. Results. The average duration of superovulation stimulation in women of the main group was 8.43±0.01 days, and in the comparison group 10.51±0.03 days (p<0.05). The number of obtained oocytes was 17.68±0.51 in group I, 14.58±0.25 in group II (p<0.05); mature oocytes 14.35±0.24 and 10.16±0.19 respectively (p<0.05). When analyzing the quality of oocytes, it was determined that 77.78% of mature eggs were obtained in the I group, and 62.5% – in the II group (p<0.05). Among mature oocytes in both groups only in two thirds of cases (74.15% and 69.0%; p<0.05) they were of high quality, while in the other there were some changes in their structure. Conclusion. Optimal for young women with tuboperitoneal infertility is a short COS protocol using prolonged-action rFSH, which allows to get more high-quality oocytes with reduction the stimulation period. Key words: tuboperitoneal infertility, in vitro fertilization, stimulation of superovulation, follicle-stimulating hormone, oocyte.