bluuebunny/crossref_metadata_2025 huggingface dataset:
Preparation of acute midbrain slices for patch-clamp recordings v4
Authors: Pavon Arocas Oriol , Branco Tiago
Published: August 2021

This protocol describes two different approaches to prepare acute midbrain slices from young adult mice for slice electrophysiology experiments. It also provides general advice for troubleshooting common issues leading to suboptimal slice quality, as well as some suggestions to ensure good maintenance of a patch-clamp rig.
Use of emission indicators related to CO2 emissions in the ecological assessment of an agricultural tractor
Authors: Rymaniak Łukasz , Merkisz Jerzy , Szymlet Natalia , Kamińska Michalina , Weymann Sylwester
Published: August 2021

The paper presents the proposed proprietary M exhaust emission indicator, which is based on the assumption that CO2 emissions are a measure of the correctness of the combustion process. The measurements were performed using a farm tractor meeting the Tier 3 emission norm, operated in real conditions during plowing work. The tests were carried out for a given land section at three speeds In the analysis of test results, the net engine work was used, as it is carried out in the type approval procedures. When measuring in real operating conditions, the torque read from the OBD system is overstated because it takes into account the engine’s internal resistance. In the analysis of test results, the fuel consumption, emission indicators of gaseous compounds and particulates were determined, and the best conditions for conducting agricultural works were indicated in terms of their impact on the natural environment. The aim of the work is to verify the possibility of determining the emission index for an off-road vehicle and a comparative analysis of its values for various operating parameters of a farm tractor. On this basis, it was found that the lowest values of the M identity were recorded for the test characterized by a vehicle speed of 15 km/h.
Assessment of flatfoot index and prevalence of musculoskeletal disorders of the foot in young athletes: swimming, rowing and weightlifting
Authors: Miguel Andrés Israel , Pons Portugal Milagros , Mayagoitia Vázquez José De Jesús , Carrum Siller Elias Gabriel , Pérez Rodríguez Ma. Eugenia
Published: August 2021

Objectives: The objective of this work was to analyze the morphology of the soles of the feet in young athletes to find the prevalence of these pathologies through the Chippaux-Smirak index.

Material and Methods: Seventy-five athletes between nine and twenty years old participated in the study (56% female and 44% male), the average mass was 62.92 ± 13.46kg and the average height was 1.67 ± 0.11m. The sports considered in the study were weightlifting, swimming, and rowing.

Results: The results clearly show that flatfeet in adolescents and young adults is a condition with a low prevalence level, 10.7% and 12% for the right and left foot, respectively. One of the most outstanding results found in the study is the high prevalence of cavus foot, where women are the most affected by this pathology. Furthermore, swimming presented the highest prevalence of cavus foot, 42.1% and 52.6% for the right and left foot, respectively.

Conclusion:  In conclusion, the understanding of the morphology of the soles of the feet can help to determine the foot type in these three different sports, and therefore, it can be implemented physiotherapeutic treatments or orthotics devices for overcome the musculoskeletal disorders and prevent future injures.
La Administración Basada en la Evidencia, en las Pymes del sector Industria de la ciudad de Bogotá
Authors:   Universidad Libre, Mayorga Sánchez José Zacarías
Published: August 2021

En la actualidad, las empresas están obligadas a repensar sus competencias, prepararse para ser competitivas y definir estrategias para sobrevivir en el escenario global. Para hacerlo, cuentan con herramientas que el conocimiento viene creando progresivamente pero que han sido ignoradas o no han sido empleadas adecuadamente. Drucker afirmó en los años 80, que “el surgimiento de la gestión empresarial como una institución distinta, fundamental y líder es un fenómeno esencial en la historia social” (Drucker, 1983, p. 1). El principal objetivo de esta investigación se centró en estudiar la utilización de las fuentes de información, de la investigación científica (conocimiento científico) y del conocimiento del entorno organizacional en la gestión empresarial de las Pymes del sector industria de la ciudad de Bogotá D.C. En el proceso se evaluó si estas empresas disponen de conocimiento, lo gestionan y hacen buen uso de los desarrollos teóricos y tecnológicos producto de la investigación y de la experiencia a nivel local e internacional en los procesos de toma de decisiones empresariales y evidenciar su incidencia en el desarrollo del sector. El modelo está diseñado para apoyar la eficiente toma de decisiones en las empresas como factor clave para el crecimiento y sostenibilidad empresarial. Es de esperarse, entonces, que se tomen decisiones analizadas y valoradas a la luz del conocimiento y las necesidades de las empresas. Para su desarrollo, se tomó como eje del conocimiento el modelo de Administración Basado en la Evidencia, modelo que, como se enuncia, centra sus desarrollos teóricos en la toma de decisiones basadas en evidencias en el medio empresarial a través de información, datos, experiencia, conocimiento científico validado, entre otros.
The impact of customer involvement in airline loyalty programs: a multigroup analysis
Authors:   University of Vale do Itajaí (UNIVALI), Brazil, Limberger Pablo Flôres , Pereira Lucimari Acosta ,   University of Vale do Itajaí (UNIVALI), Brazil, Pereira Tércio ,   University of Vale do Itajaí (UNIVALI), Brazil
Published: August 2021

Loyalty programs (LPs) have been considered a key determining factor for the performance of many companies. Although the benefits, satisfaction, perceived functional value (PFV), and loyalty (BSPfvL) have been widely explored, few studies have attempted to compare the results of this model in different groups of consumers. This study aims to analyze the relationships for varying levels of user involvement in airline loyalty programs. The population of this study was individual members of airway loyalty programs in Brazil. We obtained 429 answered questionnaires. We used multi-group analysis (MGA) using Partial least squares structural equation modeling (PLS-SEM). The results of this study indicate the mediation effect of satisfaction and perceived value and moderation of consumer involvement. A difference was identified between the two groups regarding hedonic benefits, satisfaction, and loyalty. This research has successfully contributed to the airline industry regarding the importance of loyalty benefits. Additionally, it highlights the importance of establishing consumers’ involvement in company loyalty programs. Finally, this study provides practical and theoretical contributions and guides future research efforts.
A Guide on Using Xilinx System Generator to Design and Implement Real-Time Audio Effects on FPGA
Authors:   Department of Electronics, Faculty of Technology, University of Laghouat, Laghouat 03000, Algeria, Merah L. , Lorenz P. ,   University of Haute Alsace IUT, 68008 Colmar, France, Ali-Pacha A. ,   niversity of Science and Technology of Oran (USTO), Oran 31036, Algeria, Hadj-Said N. ,   University of Science and Technology of Oran (USTO), Oran 31036, Algeria
Published: August 2021

The enormous progress in communication technology has led to a tremendous need to provide an ideal environment for the transmission, storing, and processing of digital multimedia content, where the audio signal takes the lion's share of it. Audio processing covers many diverse fields, its main aim is presenting sound to human listeners. Recently, digital audio processing became an active research area, it covers everything from theory to practice in relation to transmission, compression, filtering, and adding special effects to an audio signal. The aim of this work is to present the real-time implementation steps of some audio effects namely, the echo and Flanger effects on Field Programmable Gate Array (FPGA). Today, FPGAs are the best choice in data processing because they provide more flexibility, performance, and huge processing capabilities with great power efficiency. Designs are achieved using the XSG tool (Xilinx System Generator), which makes complex designs easier without prior knowledge of hardware description languages. The paper is presented as a guide with deep technical details about designing and real-time implementation steps. We decided to transfer some experience to designers who want to rapidly prototype their ideas using tools such as XSG. All the designs have been simulated and verified under Simulink/Matlab environment, then exported to Xilinx ISE (Integrated Synthesis Environment) tool for the rest of the implementation steps. The paper also gives an idea of interfacing the FPGA with the LM4550 AC’97 codec using VHDL coding. The ATLYS development board based on Xilinx Spartan-6 LX45 FPGA is used for the real-time implementation.
Who needs myopia control?
Authors:   State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510000, Guangdong Province, China; Department of Ophthalmology, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen 518000, Guangdong Province, China, Chen Yan-Xian , Tan Zachary ,   Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne 3010, Australia, He Ming-Guang ,   State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510000, Guangdong Province, China; Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne 3010, Australia
Published: August 2021

Myopia has become a major visual disorder among school-aged children in East Asia due to its rising prevalence over the past few decades and will continue to be a leading health issue with an annual incidence as high as 20%-30%. Although various interventions have been proposed for myopia control, consensus in treatment strategies has yet to be fully developed. Atropine and orthokeratology stand out for their effectiveness in myopia progression control, but children with rapid progression of myopia require treatment with higher concentrations of atropine that are associated with increased rates of side effects, or with orthokeratology that carries risk of significant complication. Therefore, improved risk assessment for myopia onset and progression in children is critical in clinical decision-making. Besides traditional prediction models based on genetic effects and environmental exposures within populations, individualized prediction using machine learning and data based on age-specific refraction is promising. Although emerging treatments for myopia are promising and some have been incorporated into clinical practice, identifying populations who require and benefit from intervention remains the most important initial step for clinical practice.
Socio-economic disparity in visual impairment from cataract
Authors:   Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang Province, China; Eye Institute of Zhejiang University, Hangzhou 310009, Zhejiang Province, China, Fang Zhi , Lou Li-Xia ,   Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang Province, China; Eye Institute of Zhejiang University, Hangzhou 310009, Zhejiang Province, China, Yao Ke ,   Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang Province, China; Eye Institute of Zhejiang University, Hangzhou 310009, Zhejiang Province, China
Published: August 2021

AIM: To investigate the association of visual impairment from cataract with human development index (HDI) by years lived with disability (YLDs).
METHODS: Published data on national age-standardized YLD rates caused by cataract and national HDIs in 2019 were obtained. Age-standardized YLD rates from 1990 to 2019 were analyzed to explore cataract burden among patients with different income levels. Age-standardized YLD rates in different HDI groups were compared by different degrees of visual impairment. Association between national age-standardized YLD rates and HDI in 2019 was analyzed.
RESULTS: The age-standardized YLD rates of populations with visual impairment or blindness due to cataract declined from 1990 to 2019, especially among those with lower middle income. Multiple comparison tests revealed that countries with low HDI had significantly higher age-standardized YLD rates of blindness due to cataract than those with high and very high HDI (P<0.001). The age-standardized YLD rates of populations with blindness (β= -0.588, P<0.001), severe vision loss (β=-0.378, P<0.001), and moderate vision loss (β=-0.389, P<0.001) inversely correlated with HDI.
CONCLUSION: Age-standardized YLD rates caused by cataract have declined since 1990. The burden of visual impairment due to cataract inversely correlate with national socioeconomic development and is more concentrated in countries with low HDI than those with high HDI, especially among the blind. These findings highlight the need to provide additional cataract services and cataract surgery coverage to developing countries to decrease the burden of avoidable blindness caused by cataract.
Pediatric ocular trauma with pars plana vitrectomy in Southwest of China: clinical characteristics and outcomes
Authors:   Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing 400038, China, Qin Zuo-Xin , Xu Yu-Fei ,   Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing 400038, China, Yu Tao ,   Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing 400038, China, Liu Yong ,   Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing 400038, China, Wu Nan ,   Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China; Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing 400038, China
Published: August 2021

AIM: To investigate the clinical characteristics and predictive factors of pediatric ocular trauma patients with vitrectomy.
METHODS: Pediatric ocular trauma patients (aged 14y or younger) who received vitrectomy in Southwest Hospital between January 2007 and December 2017 were reviewed retrospectively. Age, gender, mechanism of injury, final visual acuity (VA), and prognostic factors were analyzed.
RESULTS: A total of 139 eyes in 139 pediatric patients were included in the study. The mean age was 7.4±3.7 years old and the male-to-female ratio was 5:1. There were 104 (74.8%) open globe injuries and 35 (25.2%) closed globe injuries. The top one traumatic eye injuries were penetrating injuries occur through sharp metal objects (43.9%). After vitrectomy, 116 patients had favorable anatomic outcome at the last follow-up, and 30 eyes (21.6%) achieved VA of 20/200 or better. Following univariate analysis, we found zone III injuries (P=0.021), poor initial VA (P=0.005), endophthalmitis (P=0.024), and recurrent retinal detachment (P<0.001) were poor prognostic factors for pediatric ocular trauma. After Logistic regression analysis, the poor initial VA (odds ratio: 8.276, 95%CI: 1.597-42.897, P=0.012) and recurrent retinal detachment (odds ratio: 6.455, 95%CI: 2.372-17.562, P<0.001) were significantly correlated with unfavorable vision outcome in pediatric ocular trauma.
CONCLUSION: The treatment of vitrectomy for severe ocular trauma results in favorable anatomic outcomes, but VA improvement is not as good as anatomic outcomes. Initial VA and recurrent retinal detachment are the independent prognostic indicators for unfavorable visual outcome of severe pediatric ocular trauma.
miRNA-26b suppresses the TGF-β2-induced progression of HLE-B3 cells via the PI3K/Akt pathway
Authors:   Department of Ophthalmology, Ningbo Eye Hospital, Ningbo 315040, Zhejiang Province, China, Shi En , Xie Liu-Yi ,   Department of Ophthalmology, Beilun District People’s Hospital, Ningbo 315826, Zhejiang Province, China
Published: August 2021

AIM: To study the effect of miR-26b on lens epithelial cells induced by transforming growth factor beta (TGF-β) 2 and the underlying signaling pathways.
METHODS: Human lens epithelial cell line B-3 (HLE-B3) was incubated with TGF-β2 (5 ng/mL) and then transfected with miR-26b mimics. The expression of miR-26b was determined using quantitative reverse transcriptase polymerase chain reaction (qRT-PCR), while 5’-bromodeoxyuridine (BrdU) and wound-healing assays were used to measure the growth and migration of HLE-B3 cells, respectively. The expression of epithelial-mesenchymal transition (EMT) markers and the activity of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway were measured by Western blotting assay and immunofluorescence staining. Electron microscopy was also used to observe cellular morphology.
RESULTS: The expression levels of miR-26b were significantly reduced in human posterior capsular opacification-attached lens tissue and TGF-β2-stimulated HLE-B3 cells. In the presence of TGF-β2, the growth, migration, and EMT of HLE-B3 cells were distinctly enhanced; these effects were attenuated by the administration of miR-26b mimics. Furthermore, the overexpression of miR-26b significantly reduced upregulation of the PI3K/Akt pathway when stimulated by TGF-β2 in HLE-B3 cells. Moreover, the addition of an activator (740 Y-P) led to the upregulation of the PI3K/Akt pathway and abolished the protective effect of miR-26b on the HLE-B3 cells that was mediated by TGF-β2.
CONCLUSION: The miR-26b suppresses TGF-β2-induced growth, migration, and EMT in HLE-B3 cells by regulating the PI3K/Akt signaling pathway.
Five-year results of refractive outcomes and vision-related quality of life after SMILE for the correction of high myopia
Authors:   Department of Ophthalmology, Daping Hospital, Army Medical University, Chongqing 400042, China, Lang Min , Liu Ting ,   Department of Ophthalmology, Daping Hospital, Army Medical University, Chongqing 400042, China, Zhu Ying ,   Department of Ophthalmology, Daping Hospital, Army Medical University, Chongqing 400042, China, Ye Jian ,   Department of Ophthalmology, Daping Hospital, Army Medical University, Chongqing 400042, China
Published: August 2021

AIM: To evaluate the long-term visual, refractive outcomes and vision-related quality of life after small incision lenticule extraction (SMILE) for the correction of high myopia.
METHODS: Thirty patients (60 eyes) with high myopia who underwent SMILE more than 5y were selected as the SMILE group. Another 30 high myopia patients (60 eyes) who had worn corrective spectacles for more than 5y were selected as the control group. In SMILE group, the postoperative follow-up time were 3, 6mo, 1 and 5y. Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), spherical equivalent (SE), and ocular axial length (AL) were analyzed. The Chinese version of the National Eye Institute Visual Function Questionnaire-25 (CHI-NEI-VFQ-25) was used to evaluate the vision-related quality of life in the SMILE group and the control group.
RESULTS: In SMILE group, the mean preoperative SE was -7.29±0.87 D (range -6.00 to -9.125 D). At 5-year follow up, the efficacy index and safety index of SMILE were 1.09±0.18 and 1.19±0.12, respectively. Five years postoperatively, 44 eyes (73%) obtained a visual acuity of 20/20 or better. There were no eyes with CDVA loss of one or more Snellen lines. Forty-nine eyes (82%) and 57 eyes (95%) were within ±0.50 and ±1.00 D of attempted correction at 5-year follow-up, respectively. Forty-eight eyes (80%) had astigmatism <0.50 D at 5-year follow-up. The postoperative mean SE values at 3, 6mo, 1, and 5y were 0.11±0.44, 0.07±0.45, -0.02±0.41, and -0.15±0.46 D, respectively. No significant change was observed in the ocular AL from before operation to 5y postoperatively (26.08±0.96 mm vs 26.01±0.94 mm, P=0.068). Compared to the control group, the SMILE group showed a significantly higher total score on the CHI-NEI-VFQ-25 (90.14 vs 81.43, P<0.001).
CONCLUSION: In the present study, in a long-term follow-up we demonstrate that correcting high myopia with SMILE is safe, effective, and predictable. Vision-related quality of life after SMILE is better in the SMILE group than in the control group who wore corrective spectacles.
Long-term outcomes of focal laser photocoagulation for the treatment of polypoidal choroidal vasculopathy
Authors:   Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea, Choe Sooyeon , Park Kyu Hyung ,   Department of Ophthalmology, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea, Lee Christopher Seungkyu ,   Department of Ophthalmology, Institute of Vision Research, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Republic of Korea; Department of Ophthalmology, Institute of Vision Research, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea, Woo Se Joon ,   Department of Ophthalmology, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea
Published: August 2021

AIM: To evaluate the long-term effect and safety of focal laser photocoagulation treatment in eyes with polypoidal choroidal vasculopathy (PCV).
METHODS: Medical records of 13 eyes of 13 patients with PCV were followed-up for more than 2y after focal laser photocoagulation treatment. The patients were diagnosed with PCV using indocyanine green angiography, and eyes with other comorbid ocular diseases were excluded. The measurement outcomes of the study were the post-treatment regression and recurrence of polyps, complications, and changes in visual acuities. Paired t-test was performed to compare visual outcome before and after the treatment.
RESULTS: The mean age of the 13 patients was 70.2±5.5y, and the follow-up period was 72.3±31.0 (range, 25-118)mo. Three eyes had juxtafoveal polyps and 10 eyes had extrafoveal polyps. Of the 13 eyes, 9 eyes (69.2%) had regression of polyps 1.7±1.2 (range, 0.9-4)mo after focal laser photocoagulation. Five eyes (55.6%) showed recurrence of polyps during the follow-up periods, and the recurrence period was 12.8±18.9 (range, 1.9-48)mo. Mild subretinal hemorrhage occurred in two eyes (15.4%) 27 and 72d after laser treatment, respectively. There were no statistically significant differences in visual acuities at baseline; 1, 2, 3y post-treatment (all P>0.05); and last follow-up (0.63±0.5, 0.73±0.70, 0.67±0.57, 0.75±0.7, and 0.95±0.8 logMAR, respectively).
CONCLUSION: Focal laser photocoagulation is beneficial for early regression of polyps in eyes with PCV and does not result in significant submacular hemorrhage during the long-term follow-up. Furthermore, it can be primarily considered in eyes with PCV with extrafoveal or juxtafoveal polyps to regress risky polyps as well as to maintain visual acuity without serious hemorrhagic complications.
Association between cystatin C and diabetic retinopathy among type 2 diabetic patients in China: a Meta-analysis
Authors:   Department of Medical Informatics, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China, Yang Nan , Yang Xiao ,   Department of Medical Informatics, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China, Jiang Kui ,   Department of Medical Informatics, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China, Sang Ai-Min ,   Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China, Wu Hui-Qun ,   Department of Medical Informatics, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China
Published: August 2021

AIM: To explore the correlation between cystatin C (Cys-C) and diabetic retinopathy (DR) in those patients with type 2 diabetes mellitus (DM) in China.
METHODS: Articles were collected from China National Knowledge Infrastructure (CNKI), Wanfang, VIP, PubMed, EMBASE, Cochrane Library, Clinical Trials.gov, and Google Scholar. Quality and risk of bias within included studies was assessed using the Newcastle-Ottawa scale (NOS). Heterogeneity was determined by using Cochran’s Q-test and Higgins I2 statistics. Mean differences (MDs) and 95% confidence intervals (CIs) of Cys-C within the diabetes without retinopathy (DWR) and DR, DWR and non-proliferative diabetic retinopathy (NPDR), NPDR and proliferative diabetic retinopathy (PDR) were collected by using random-effects model because of high heterogeneity. Meta-analysis was conducted based on 23 articles of 2331 DR including NPDR and PDR patients and 2023 DWR patients through Review Manager 5.3. Subgroup analyses were also performed according to DM duration, body mass index (BMI), total cholesterol (TC), total triglycerides (TG), low-density lipoprotein C (LDL-C), and high-density lipoprotein C (HDL-C), sample origins and methods. Publication bias was assessed by the funnel plot.
RESULTS: Cys-C level in DR patients was increased compared with that of DWR (total MD: 0.69, 95%CI: 0.41 to 0.97, Z=4.79, P<0.01). Besides, the synthesized results of the studies showed the similar findings in the DWR vs NPDR group (total MD: 0.29, 95%CI 0.20 to 0.39, Z=6.02, P<0.01) and the NPDR vs PDR group (total MD: 0.63, 95%CI 0.43 to 0.82, Z=6.33, P<0.01). Heterogeneity of most of the subgroup analyses was still obvious (I2?≥?50%, P?<?0.1). Forest plots of different subgroups indicated that there was a slight increase of Cys-C during the period between DWR and DR, DWR and NPDR, NPDR and PDR. Funnel plot showed that there was no significant publication bias.
CONCLUSION: The elevated Cys-C is closely related with DR and probably plays a critical role in its progression.
Condutas práticas e efetivas do cirurgião-dentista frente ao paciente em tratamento de câncer de cabeça e pescoço: revisão de literatura
Authors: Alves-Silva Esdras Gabriel , Caldas José Manuel Peixoto , Gomes Brenda Paula Figueiredo de Almeida , Carvalho Rejane Andrade de , Soares Maria Sueli Marques , Veloso Heloísa Helena Pinho
Published: August 2021

O objetivo do presente estudo é salientar através de uma revisão de literatura os possíveis cuidados que o cirurgião dentista precisa ter frente aos principais agravos bucais decorrentes do tratamento oncológico. Os trabalhos foram obtidos através dos sistemas de dados PUBMED, MEDLINE, BBO, SCIELO, LILACS, SCIENCE DIRECT, COCHRANE E BBO. A principal estratégia para o combate de tais neoplasias é na forma de prevenção, ainda que o câncer tenha como um dos fatores etiológicos a hereditariedade, a exposição a determinados agentes (fumo, álcool, HPV, etc.) podendo aumentar as chances de sua ocorrência. Os métodos tradicionais de tratamento oncológico são a cirurgia, a radioterapia e a quimioterapia. O tratamento a ser instituído estará na dependência da localização, do grau de malignidade e da condição de saúde do indivíduo. O cuidado dentário antes do tratamento oncológico visa a redução do risco e a gravidade das complicações orais, prevenir, eliminar ou reduzir a dor de origem bucal, preservar ou melhorar a saúde bucal, contribuindo para a melhoria da qualidade de vida. Conclui-se que diante dos efeitos colaterais importantes aos tecidos bucais, é de suma necessidade o conhecimento por parte do cirurgião dentista, para que possa atuar na prevenção e redução de tais danos.
Bactéria cromogênica associada a manchas negras
Authors: Boeira da Silva Maiquiele , Gazzoni Alexandra Flávia , Gaboardi Guilherme , Da Rosa Hoffmann Elias , Galafassi Daniel
Published: August 2021

Objetivos: Este trabalho tem como objetivo avaliar a associação das bactérias Prevotella Melaninogênica e Actinomyces ao biofilme escuro em dentes permanentes. Relato de Caso: Um paciente que apresentou manchas enegrecidas ao longo do contorno cervical dos dentes foi convidado a participar do presente estudo. Após seu esclarecimento e aceitação, preenchendo o TCLE, foi coletado com o auxílio de uma cureta estéril, uma parte deste biofilme que foi inserido em um eppendorff contendo soro fisiológico. O material coletado foi agitado em um Vórtex por 15 segundos e em seguida, inoculadas em 100 microlitros (µl) da solução em um meio de ágar sangue suplementado com Canamicina 5%, seguido de cultivo por 72 horas. A partir do crescimento bacteriano, as mesmas foram isoladas em ágar macconkey, chocolate e sangue em anaerobiose. Em seguida foram realizados testes de bioquimismo, utilizando-se os meios MIO (motilidade, indol e ornitina), citrato, TSI (triplo açúcar com ferro) e LIA (ágar lisina com ferro). Conclusão: Através das características clínicas associadas ao bioquimismo empregado nos testes, podemos concluir que a bactéria que está associada as manchas negras presentes no paciente é do gênero prevotella spp.
Manifestações bucais oriundas do consumo de crack
Authors: Spezzia Sérgio
Published: August 2021

Objetivo: O crack têm sido muito consumido nos dias atuais, configurando a droga ilícita de predileção dentre as disponíveis para uso, tendo em vista que essa droga é capaz de ocasionar dependência química ao usuário, sendo ao mesmo tempo de custo reduzido para aquisição. Muitas implicações odontológicas são evidenciadas em âmbito bucal, advindo do emprego do crack. O objetivo do presente artigo foi averiguar acerca das implicações bucais que o uso do crack pode acarretar. Método: Realizou-se revisão bibliográfica com levantamento nas bases de dados bibliográficas: Google Acadêmico, LILACS, PubMED de estudos e artigos que versavam acerca das manifestações orais ocasionadas, devido o emprego do crack. Resultados: Relacionado as implicações odontológicas presentes advindo do consumo do crack, pode-se ter desencadeamento de doenças periodontais, como gengivite e periodontite; lesões na mucosa bucal; redução do fluxo salivar; acometimento por lesões de cárie; perdas dentárias e negligenciamento por parte dos pacientes usuários do seu autocuidado com a higienização oral. Em pacientes que encontram-se em situação de dependência química frente ao consumo do crack apenas existe percepção das condições precárias da sua saúde oral quando da convivência com a abstinência a essa droga. Conclusão: A abordagem odontológica que é fornecida aos usuários do crack é fundamental para que se evite complicações futuras e a execução de tratamentos odontológicos curativos dotados de maior complexidade, nesse contexto, convém que essa abordagem ocorra precocemente.O crack têm sido muito consumido nos dias atuais, configurando a droga ilícita de predileção dentre as disponíveis para uso, tendo em vista que essa droga é capaz de ocasionar dependência química ao usuário, sendo ao mesmo tempo de custo reduzido para aquisição. Muitas implicações odontológicas são evidenciadas em âmbito bucal, advindo do emprego do crack. O objetivo do presente artigo foi averiguar acerca das implicações bucais que o uso do crack pode acarretar. Realizou-se revisão bibliográfica com levantamento nas bases de dados bibliográficas: Google Acadêmico, LILACS, PubMED de estudos e artigos que versavam acerca das manifestações orais ocasionadas, devido o emprego do crack. Relacionado as implicações odontológicas presentes advindo do consumo do crack, pode-se ter desencadeamento de doenças periodontais, como gengivite e periodontite; lesões na mucosa bucal; redução do fluxo salivar; acometimento por lesões de cárie; perdas dentárias e negligenciamento por parte dos pacientes usuários do seu autocuidado com a higienização oral. Em pacientes que encontram-se em situação de dependência química frente ao consumo do crack apenas existe percepção das condições precárias da sua saúde oral quando da convivência com a abstinência a essa droga. A abordagem odontológica que é fornecida aos usuários do crack é fundamental para que se evite complicações futuras e a execução de tratamentos odontológicos curativos dotados de maior complexidade, nesse contexto, convém que essa abordagem ocorra precocemente.
Influência do polimento na estabilidade de cor de uma resina composta após imersão em diferentes substâncias corantes
Authors: Amaral Nicole Ruppenthal , Portella Fernando Freitas , Zimmer Roberto , Reston Eduardo Galia , Arossi Guilherme Anziliero
Published: August 2021

Objetivo: Avaliar o grau de pigmentação da resina composta imersa em água destilada, molho shoyu e vinho tinto, submetida a diferentes métodos de polimento. Método: Foram confeccionadas 90 espécimes de resina composta cor A2 esmalte (4 mm de diâmetro de topo, 3 mm de diâmetro de fundo e 2 mm de espessura), divididos igualmente em três grupos, de acordo com o tratamento superficial realizado (sem polimento, polimento com Diamond Pro e polimento com lixa). As 30 amostras de cada grupo foram divididas em três subgrupos (n=10) e imersas em diferentes soluções (água, molho shoyu e vinho tinto). A análise colorimétrica foi realizada previamente, 7 e 15 dias após a imersão das amostras nas soluções, com o auxílio de um colorímetro. Os dados foram submetidos aos testes de ANOVA/Tukey considerando um nível de significância de 5%. Resultados: Amostras imersas em água apresentaram pequena variação de cor (E=2,2), com exceção das que não receberam polimento (E=7,8). O vinho tinto apresentou significativo maior potencial de pigmentação (E=15), independente do método de polimento, enquanto o molho shoyu (E=11) demonstrou pigmentar com maior intensidade as amostras polidas com discos de lixa. Conclusões: É necessário fazer um acabamento e um polimento adequado na restauração de resina composta para que o grau de pigmentação seja o menor possível. Sobre os alimentos corantes, conclui-se que tanto o molho shoyu quanto o vinho tinto pigmentam a resina composta, porém o vinho pigmenta com uma intensidade maior.
Immediate implant placement after maxillary sinus lift using the side window technique: clinical case report
Authors: Angeloni de Souza Fernanda , Pradebon Brondani Lucas , Del Conte Valcanaia Tulio , Kuhn Dall'Magro Alessandra , Borges da Fonseca Cumerlato Catarina , Coelho Blois Matheus
Published: August 2021

Objetivos: O objetivo deste caso clínico foi relatar uma reabilitação unitária da região posterior da maxila, e descrever a cirurgia de levantamento de seio maxilar através da técnica de janela lateral, com colocação imediata de implante. Métodos: A cirurgia de levantamento de seio foi realizada através da técnica de janela lateral, seguida da instalação imediata do implante e posterior confecção de prótese unitária aparafusada. Resultados: Foi observada a reabilitação do elemento dental perdido através do reestabelecimento do espaço ósseo por meio da cirurgia de levantamento de seio, permitindo assim a instalação do implante imediato e confecção da prótese final. Conclusões: Seguindo um planejamento sólido e meticuloso, mesmo em cristas com menos de 5 mm de espessura, a técnica de janela lateral pode ser usada de forma previsível com um resultado clínico e radiológico adequado, dando aos pacientes excelente estabilidade do material enxertado e excelentes resultados clínicos.
Novas perspectivas para reabilitação de dentes tratados endodonticamente
Authors: Dalla Valle Alânia Agassis do Nascimento , Von Meusel Luiza Dal Zot , Knack Kelly , Dotto Lara , Maroli Angelica , Sarkis-Onofre Rafael , Spazzin Aloísio Oro , Rocha Pereira Gabriel Kalil , Bacchi Atais
Published: August 2021

Vários fatores podem influenciar o desempenho clínico de dentes com tratamento endodôntico (DTE). Além disso diversas são as opções restauradoras indicadas em respeito a este cenário, em especial com o notório avanço de novas técnicas e tecnologias para uso clínico. Dentre estas corriqueiramente envolvem-se o uso de restaurações diretas (confeccionadas com resina composta), pinos metálicos ou de fibra de vidro, pinos pré-fabricados ou fresados, assim como restaurações indiretas compostas de coroas cerâmicas, inlays, onlays ou endocrowns; sempre com o foco na reabilitação funcional e estética do caso em tela. Neste trabalho, através de uma revisão narrativa, foram expostos conceitos relativos às modalidades restauradores que se advêm do uso de novas tecnologias na reabilitação de dentes tratados endodonticamente.
Evaluation of the relationship between serum estradiol levels on human chorionic gonadotropin administration day and intracytoplasmic sperm injection outcomes: A retrospective population-based study
Authors: Hajshafiha Masoumeh , Oshnouei Sima , Mostafavi Mahdieh , Dindarian Sina , Kiarang Nazila , Mohammadi Sedra
Published: August 2021

Background: The correlation between high estradiol (E2) levels induced by controlled ovarian hyperstimulation (COH) and pregnancy is controversial.
Objective: To assess the effect of serum E2 levels on the day of human chorionic gonadotropin administration on the intracytoplasmic sperm injection (ICSI) outcome.
Materials and Methods: The current study included 551 participants who had undergone ICSI between May 2014 and May 2016. Based on E2 levels, the individuals aged < 37 yr (n = 502) and 37-42 yr (n = 49) were categorized into six and three groups, respectively. ICSI outcomes including the number of retrieved oocytes (NRO), number of embryos (NE), pregnancy rate, and abortion rate were analyzed in both groups.
Results: Among participants aged < 37 yr, the NRO and NE were 8.69 ± 3.82 and 5.24 ± 2.32, respectively and they had a significant correlation with the E2 level on human chorionic gonadotropin administration day (p < 0.001 for both). Among participants aged > 37 yr, NRO and NE were 5.18 ± 3.17 and 3.40 ± 2.23, respectively, and the NRO (p < 0.001), NE (p < 0.001), pregnancy rate (p < 0.001), abortion rate (p = 0.007), and the number of grade A and B embryos (p = 0.003) had a significant association with the E2 level.
Conclusion: COH is a costly procedure that may have negative effects on endometrial receptivity. Thus, in order to prevent these effects and also to reduce the costs of COH, we recommend gaining optimum number of oocytes rather than maximum number during the procedure.
Key words: Intracytoplasmic sperm injection, In vitro fertilization, Estradiol, Pregnancy.
The effect of acrylamide on sperm oxidative stress, total antioxidant levels, tyrosine phosphorylation, and carboxymethyl-lysine expression: A laboratory study
Authors: Hosseinpoor Kashani Mojdeh , Ramezani Mina , Piravar Zeinab
Published: August 2021

Background: Acrylamide (AA) is a reactive molecule produced during food processing at temperatures above 120°C.
Objective: To evaluate the impact of different concentrations of AA on human sperm parameters, oxidative stress and total antioxidant capacity (TAC).
Materials and Methods: In this laboratory study, semen samples were obtained from healthy donors referred to the Taleghani Hospital, Tehran, Iran between June and July 2019. Samples were divided into four groups (n = 10/each): one control and three treatment groups (0.5, 1, and 2 mM of AA). After 2 hr of exposure to AA, the superoxide dismutase and malondialdehyde levels were measured based on colorimetric methods. The TAC was determined by the ferric-reducing antioxidant power assay. Flow cytometry was performed to measure the intracellular reactive oxygen species generation. Also, immunohistochemistry was done to determine the effect of AA on tyrosine phosphorylation and carboxymethyl-lysine expression.
Results: Results of the study demonstrated that the motility and viability of spermatozoa were significantly decreased after AA exposure (p < 0.001). This decrease was also seen in the TAC and superoxide dismutase activity as well as in the phosphotyrosine percentage compared with the control (p < 0.01). However, the carboxymethyllysine and prooxidant activity including reactive oxygen species generation and lipid peroxidation level increased (p < 0.001).
Conclusion: Overall, the results confirmed the detrimental effect of AA on human spermatozoa which may be due to oxidative stress and decreased total antioxidant levels. AA may reduce fertility by reducing sperm capacitation and motility.
Key words: Acrylamide, Oxidative stress, Antioxidant, Spermatozoa, Infertility.
Documentos digitalizados e elaboração de conhecimentos para a história da educação matemática
Authors: Gomes Victor Hugo de Lemos , Valente Wagner Rodrigues
Published: August 2021

A crescente utilização de repositórios digitais, bem como a expansão do volume de documentos disponíveis para análise e uso como fontes de pesquisas, exigem uma adequação no modo de realizar investigações de forma a potencializar os seus resultados. O objetivo deste artigo é apresentar uma nova ferramenta para elaboração de conhecimento, no âmbito da história da educação matemática, apresentando-a por meio de um estudo de caso. Utilizando uma análise lexicométrica, aliada ao uso de softwares de processamento de dados, como o IRAMUTEQ, as pesquisas ganham a possibilidade de uso de múltiplos textos potencializando o processo de análise e diminuindo sobremaneira o tempo gasto no trabalho. Esse expediente permite o cruzamento de dados e informações tendendo a amplificar os resultados dos estudos em história da educação matemática.
Uma revisão sistemática de literatura acerca dos trabalhos sobre a interface entre ensino e história da matemática
Authors: Alves Feitosa Raphael , Coelho da Silva Isabelle
Published: August 2021

O objetivo da presente investigação é analisar a literatura, em língua portuguesa, que vem sendo publicada acerca da interface entre história da matemática e ensino, sobretudo os textos científicos oriundos de periódicos revisados por pares. Com isso, busca-se colaborar para uma compreensão sobre os pontos recorrentes das investigações nesta interface, bem como detectar possíveis lacunas que o campo possui. Para tanto, recorremos à pesquisa de literatura do tipo sistemática, realizada no Portal de Periódicos CAPES. Como resultado, foram selecionados 19 artigos relacionados ao assunto. Esse levantamento mostra que o tema tem sido cada vez mais abordado, mas ainda há lacunas a serem explanadas, principalmente, em relação às ações pedagógicas planejadas e organizadas dentro das instituições de ensino.
Luz, câmera, alfabetização científica! Possibilidades epistemológicas no antagonismo ciência-pseudociência da série Cosmos de Carl Sagan
Authors: Melo Marcos Gervânio de Azevedo
Published: August 2021

O objetivo desse artigo é investigar contribuições ao processo de alfabetização científica e tecnológica quando se busca compreender a distinção entre ciência e pseudociência pela análise da série Cosmos de Carl Sagan. No terceiro capítulo desta série, fala-se da ligação que existira entre astronomia e astrologia, oportunizando-se interpretações nas quais os planetas, por exemplo, afetariam o caráter e o destino das pessoas. Este capítulo possibilita refletir sobre visões de ciência, oportunizando-se contemplar as concepções indutivista, o raciocínio lógico dedutivo, bem como o falsificacionismo de Popper. Contudo, oportuniza-se, também, pensar sobre as características da pseudociência e o quanto estivera ligada à ciência noutrora. Foi possível articular trechos da série a um dos eixos estruturantes de alfabetização científica propostos por Sasseron e Carvalho e, por meio da análise de conteúdo de Bardin, estabelecer inferências. A simples possibilidade de se compreender que a ciência elimina seus erros para prosperar e que suas hipóteses surgem oferecendo a possibilidade de serem refutadas, representa um elemento fundamental para diferenciá-la da pseudociência, pois a hipótese pseudocientífica, por outro lado, é gerada buscando alcançar invulnerabilidade a qualquer observação que possa refutá-la.
Política exterior colombiana, 2010-2018; entre la percepción de los tomadores de decisiones y la cultura estratégica
Authors: González Parias Carlos Hernán
Published: August 2021

El presente libro se concibe, fundamentalmente, desde dos necesidades. La primera de ellas incorporar, al análisis de la política exterior colombiana, propuestas teóricas y conceptuales, que permitan una comprensión amplia de su complejo proceso, conciliando, la tradicional división entre factores internos y externos. Por otra parte la necesidad de comprender y explicar la política exterior, en un periodo, que, según varios académicos especializados, se caracterizó por ser dinámica, compleja, con diferentes objetivos y que, en algunos aspectos, rompió con el curso tradicional de esta política. Por lo tanto, el objetivo central de la investigación es explicar el rol de variables domésticas intervinientes: La percepción de los tomadores de decisiones y la cultura estratégica, en formulación y ejecución de la política exterior colombiana en el periodo 2010-2018.
The Improvement of the Summary Jurisdiction Procedure in the Russian Civil Proceedings for the Implementation of the Principles of Procedural Economy
Authors:   Assistant Judge of the Supreme Court of the Mari El Republic Postgraduate Student of the Department of Civil Law and Procedure of the Mari State University, Artizanov Aleksey I.
Published: August 2021

The Institute of simplified proceedings was introduced into the civil procedure legislation in March 2016 and was to increase justice availability, court procedures optimization, its precipitation and simplification. It certainly corresponds to the basic postulates of procedural economy principles, which in turn imply the effectiveness of the court’s protection of citizens’ violated rights and freedoms by saving financial and necessary for the case consideration time resources. This article is devoted to analysis of the Institute of simplified proceedings, problems associated with procedural rules application in the context of the procedural economy principle, as well as improving this procedural institution ability.
Development of Scientific Views of Taxation of Military Servicemen
Authors:   Employee of the Equitas Center for Russian Law Research PhD (Law), Trofimov Maksim V.
Published: August 2021

The article examines the historical aspects of legal regulation of taxation of military personnel. The most important legal monuments are considered and the statements of Russian scientists who formulated the theoretical bases of taxation of military personnel are given.