bluuebunny/crossref_metadata_2025 huggingface dataset:
RECENT PATENTS ON SOLID DISPERSIONS OF ANTIHYPERLIPIDEMIC DRUGS
Authors: SINGH PRITAM , NANDA ARUN
Published: March 2023

Hyperlipidemia is a worsening health condition in developed and developing countries, especially among the younger generation due to their lifestyle. The World Health Organization reported 2.6 million deaths globally due to hyperlipidemia. Therefore, there is a huge demand of antihyperlipidemic drugs in the pharmaceutical market. Approximately 60% of the total active drug content used in hyperlipidemia suffer from poor water solubility, particularly BCS class II drugs. Poor water solubility may result in insufficient absorption and finally affects the bioavailability of the drug causes ineffectiveness in lowering lipid profile of patients. In recent years, solid dispersion technology has proved to be a simple, effective and economical approach for industrial application to increase the solubility of these drugs. This review paper is an attempt to compile up various research as well as patents reports related to solid dispersions of poor water soluble antihyperlipidemic drugs.
FORMULATION AND CHARACTERIZATION OF SELF NANO-EMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) FRACTION OF N-HEXANE: ETHYL ACETATE FROM SESEWANUA LEAF (CLERODENDRUM FRAGRANS WILD.)
Authors: SAPIUN ZULFIAYU , IMRAN ARLAN K. , ROSMALA DEWI SISILIA TERESIA , MASITA PADE DHEA FADILA , IBRAHIM WIDYAWATI , TUNGADI ROBERT , ABDULKADIR WIDY SUSANTI , BANNE YOS , RIFAI YUSNITA , SARTINI SARTINI , PERMANA ANDI DIAN , RIFAI YUSNITA , YSRAFIL YSRAFIL , SLAMET NANGSIH SULASTRI
Published: March 2023

Objective: Sesewanua leaves contain alkaloid compounds as antioxidants, and its leaves can be used to formulate SNEDDS dosage forms, which can effectively deliver the medicine.
This study intended to determine the variation of surfactant concentration (Tween 80) and cosurfactant (PEG 400) towards pH, viscosity, nano-emulsion duration and characterization using PSA method (particle size and polydispersity index).
Methods: This study employed a quasi-experimental method and the independent variables in this study were variations in the concentration of surfactant (Tween 80) and cosurfactant (PEG 400), which consist of 3 formulas, such as SFS 1 (6:3), SFS 2 (7:2), and SFS 3 (8:1). The dependent variables in this study including pH, viscosity, nano-emulsion time, particle size and polydispersity index which utilized One Way Anova Post Hoc LSD (p>0.05) and Tamhane (p<0.05) tests as the data analysis.
Results: The pH test SFS1-SFS3 has a pH value of 7.92, 8.30 and 8.35, followed by Viscosity test SFS1-SFS3, which has a viscosity value of 1.00 cP, 1.38 cP and 2.91 cP. Further, the SFS1-SFS3 nano emulsified time test had nano emulsified time in gastric and intestinal fluids 35.18s and 43.96s, 43.54s and 47.13s and 44.00s and 50.29s. Characterization of SFS1-SFS3 particle size in gastric and intestinal fluids 23.9 nm and 23.0 nm, 18.5 nm and 22.7 nm and 19.1 nm and 22.9 nm, while characterization of SFS1-SFS3 polydispersity index in gastric and intestinal fluids were 0.433 and 0.348, 0.451 and 0.440 and 0.568 and 0.462.
Conclusion: The increase of variations in surfactant concentration and decreased cosurfactant significantly affected pH, viscosity, nano-emulsion time, and particle size of SFS preparations. However, the polydispersity index was not considerably affected.
NICORANDIL MUCOADHESIVE MICROSPHERES: FORMULATION DEVELOPMENT, PHYSICO-CHEMICAL AND FUNCTIONAL CHARACTERIZATION
Authors: HADKE ANKITA V. , PETHE ANIL M. , KESALKAR MAHESH A.
Published: March 2023

Objective: The study aims to prepare and evaluate Nicorandil mucoadhesive microspheres to improve the oral physicochemical properties of nicorandil and mucoadhesion to extend the residence time at the absorption site. Methods: Nicorandil mucoadhesive microsphere was prepared by emulsion cross-linking method using fenugreek gum, karaya gum as polymer, and glutaraldehyde as a cross-linking agent. Drug entrapment efficiency, particle size, % swelling index, mucoadhesion study, differential scanning calorimetry, powder x-ray diffraction, Fourier transform infrared spectroscopy, and in vitro dissolution studies were used to characterize the microspheres. Results: The characterization studies indicated the formation of mucoadhesive microspheres. The nicorandil mucoadhesive microspheres particle size is130.83±0.48, entrapment efficiency 66.91±0.54, swelling index 82.69±0.40, % mucoadhesion 95.22±0.13 and in vitro drug release was found to be 89.96±0.17 % at the end of 12 h. Conclusion: This research work successfully formed nicorandil mucoadhesive microspheres formulation using the emulsion cross-linking method. Encapsulation efficiency and other physicochemical and functional characterization of microspheres suggested the successful formation of nicorandil mucoadhesive microspheres.
REGULATORY FRAMEWORK: VACCINE DEVELOPMENT IN US, INDIA AND EU
Authors: PONNAPALLI RAMYA , DIVYA MANTENA SRI LAKSHMI , RAJU KALIDINDI VENKATESWARA , NORI LAKSHMI PRASANTHI
Published: March 2023

Vaccine development usually takes around 7 y to come to the market after getting necessary regulatory approvals. But recent pandemics like Covid, Ebola, Swine Flu, have resulted in the collaboration of efforts between the government doing investments in vaccine development, academia, regulatory bodies, and industry. This has shortened the timelines for approval for vaccines. In 2009, HINI, Swine flu vaccines took 93 d for identifying the vaccine candidate for clinical trials. In 2014, for Ebola vaccine, it was deployed while the epidemic was still going on. Ebola vaccine was developed in 5 y. In case of Covid (SARS-CoV-2) clinical trials were approved when 2 mo of the pandemic onset. Within a time of 9 mo about 138 vaccine candidates are being reviewed for approval of EUA. This highly helps in the shortening of vaccine development and necessary approval. In this paper, we focused on the regulatory framework of vaccine development in INDIA, US and EU.
RELIABLE SPECTROSCOPIC ANALYTICAL PROCEDURE FOR QUANTITATIVE ESTIMATION OF OSIMERTINIB MESYLATE IN LIPOSOMAL DRY POWDER INHALER FORMULATION
Authors: PATIL MANSING , PATEL PINKAL
Published: March 2023

Objective: The objective of the present study was to develop an economical UV spectrophotometric method with a simple, rapid, accurate, precise, sensitive, and reproducible for the quantitative estimation of Osimertinib Mesylate (OM) in bulk and newly prepared Liposomal Dry Powder Inhaler (LDPI) formulation which has not been reported earlier. Methods: Different dilutions were prepared in methanol in the range of 4-16 µg/ml, scanned between 400-200 nm, and determined the maximum absorbance was to confirm the drug’s λmax. Linearity, accuracy, precision, the limit of detection (LOD), and the limit of quantitation (LOQ) were used as parameters to validate the method. The concentration of the OM was calculated based on a linear regression equation of the calibration curve. Results: The UV spectrum of OM showed λmax at 267 nm and a linear calibration curve with a regression coefficient (R2) of more than 0.997. The RSD for recovery studies was found ˂ 2 % and confirmed the accuracy of the proposed method. The LOD and LOQ were observed at 0.021 µg/ml and 0.063 µg/ml, respectively for bulk and 0.056 µg/ml and 0.170 µg/ml for OM LDPI formulation. The method was found to be precise with an RSD ˂ 2 %. Conclusion: The present UV spectrophotometric method can be used to successfully estimate OM in LDPI, and there is no interference of excipients during the study. The method is validated in compliance with International Conference on Harmonization (ICH) guidelines and it should be used as a routine quality control analysis i.e., assay for such dosage forms.
PROCESS VALIDATION OF BETA-SITOSTEROL HAIR GEL FORMULATION AND EVALUATION OF 5 ALPHA REDUCTASE INHIBITION IN VITRO FOR THE TREATMENT OF ANDROGENETIC ALOPECIA
Authors: CHAKRABORTY ARPAN , BHATTACHARJEE ARKA , CHAKRABORTY MANAS , MUKHOPADHYAY GOUTAM
Published: March 2023

Objective: The present study was aimed to develop topical gel containing β-sitosterol using carbopol 940 as a gelling agent and to investigate 5 alpha reductase (5α-reductase) inhibitory activity of suitable gel formulation and compare it with a commercial product used topically for alopecia.
Methods: Three different batches of β-sitosterol hair gel formulation were manufactured and evaluated. Additionally, the 5α-reductase inhibitory activity of the prepared formulation, finasteride as a positive control, was evaluated and compared to the commercial herbal formulation used.
Results: According to the analytical findings of three different batches, the gel formulation is good in appearance, homogeneous, and easily spreadable. Based on findings from HPLC and HPTLC, the amount of β-sitosterol in those formulations complies with the label claim. By checking different critical parameters of those batches, we established the manufacturing process method validation and the process reproducibility. In vitro results showed the good 5α-reductase inhibitory potential of prepared gel formulation and then commercial product. The IC50 value of the prepared formulation was 118.960±0.634 (µg/ml) and standard beta-sitosterol 88.854±0.70 (µg/ml), whereas Finasteride (positive control) 224.372±3.103 (ng/ml).
Conclusion: Thus, β-sitosterol formulation utilises a straightforward, low-cost production, less time-consuming process with minimal facility and equipment requirements. The formulation may be a promising candidate for future investigation into their antiandrogenic activities.
Уран зохиолыг өнөөгийн гадаад хэлний сургалтанд ашиглах нь
Authors: Capitain J.
Published: March 2023

My article about using A.A.Milne’s iconic children’s book Winnie-the-Pooh in the language classroom tries to show how important literature can be in the modern language classroom to activate students and to make lessons more lively. One enormous advantage of Winnie-the-Pooh is that it is easily accessible as a book, but that it can also be downloaded as a text or in various recordings for free so that it can be an excellent help to improve students’ pronunciation and intonation of the English language. In my article I have listed a number of pre-reading, while-reading and post-reading exercises which help to rouse young learners’ interest and which allow a wide variety of speaking and writing exercises. Thus, they help students to build up and consolidate vocabulary and grammatical structures. Furthermore, apart from helping students to improve their language skills in a lively and creative way, they may lead to more complex discussions about cultural aspects.
Ментал модел болон дискурсив хандлагыг "хэл-математик" загвараар шинжлэх нь
Authors: Дагиймаа Б.
Published: March 2023

This research examines how to create knowledge which is a base of the macrostructure and global meaning of discourse. The meaning of keywords and concepts that express the global meaning of the discourse, were weighed mathematically to determine the significant value. These top rank of weighted words are considered as a cognitive mapping and mental model within knowledge theory and information structure theory, developed by the Fairclough, Teun A. van Dijk and B. Dagiimaa,and Dagiimaa Balaanz & Munkhchimeg Otgonchuluun Text Mining Applications in Discourse Analysis and Modern Trends (Big Data Methods on Political Speeches), thus here, aimed to identify and analyze authors opinion and attitude in political speech. Through the analysis, aimed to identify the author's attitude, has been reviewed the creation of discourse mental model is a direct representation of attitude from the author within mental space described by knowledge, presupposition from the situation, then understanding of the issues is people take information directed by the author’s attitude and belief, also tried to find out how interviewer uses discourse tools to approach and discover the guest’s attitude at all.
Repressive Policy as a Tool of Resolving the “Chinese Issue” in the USSR in the 1930s
Authors: Ablazhey Natalya N. , Potapova Natalya A.
Published: March 2023

The authors analyze the dynamics of repressions in the 1920-1930s towards Chinese people permanently residing on the territory of the USSR. There is illustrated the interdependence of the naturalization of the Chinese and the punitive policy. It is shown that in the period of 1929-1936 there were several anti-Chinese campaigns in the Far East and Siberia, and there is given an assessment of their consequences. The authors refute the hypothesis of conducting a special “Chinese” operation in the USSR during the Great Terror of 1937-1938. Based on the materials of extrajudicial bodies and reporting statistics of the NKVD, it is concluded that this category of the population was referred to two “national” categories, namely, “Harbin” and “mixed.” It is proved that from February 1938 terror against the Chinese was escalated, but only in September 1938 did an independent “Chinese” category appear in the statistics of the NKVD; in total, during the years of the Great Terror, about 18,000 Chinese underwent “national” punitive actions. Repressions against them were justified by a single logic implemented in relation to foreign nationals, which nevertheless allowed some regions to intensify repressions against certain ethnic groups. It is well documented that the expulsions of Chinese outside the country were widely used; they were organized repressive campaigns. It is concluded that the political repressions and state actions in the field of naturalization led to the reduction in the size of the Chinese diaspora and changed the geography of its settlement.
Shelter for the Afflicted: Migration from Xinjiang to Russia in the 1860s-1880s
Authors: Vasilyev Dmitry V. , Asanova Svetlana A.
Published: March 2023

The authors examine the history of the migration of Chinese subjects from the territory of Xinjiang in the 1860s-1880s and measures taken by the Russian administration aimed at adapting them to the new socio-political and economic conditions. On the basis of the research, the waves and scales of migration are established and their reasons are named. The study of the sources is implemented using the formal legal method, the comparative legal method, the methods of analysis and synthesis of written sources, as well as induction. The application of these methods made it possible to formulate a general conclusion concerning the policy of the Russian Empire in relation to the non-Russian population of the region, including Chinese immigrants. The study of the documents related to the migration of the Xinjiang population to the territory of Russian possessions in Central Asia convinces us that the authorities of the Russian Empire were interested in this process. They sought to find a place for new subjects in the socio-economic communities of the indigenous population of the Turkestan territories. At the same time, the Russian authorities applied to the Chinese settlers the norms characteristic of both nomadic and settled residents. Their goal was to bring the status of former Chinese subjects closer to the status of the main population of the state. The Russian government sought to complete this adaptation through the merger of the former Qing subjects with the population of the internal provinces of the Russian Empire.
Relationship of Russian Merchants with the Tuvan Population in the Second Half of the 19th - Early 20th Century
Authors: Kiskidosova Tatiana A.
Published: March 2023

The author identifies the main factors that influenced the relationship between Russian merchants and the Tuvan population in the second half of the 19th - early 20th centuries taking into account a number of features and attracting new sources. The author studies the influence of debt trade on Russian-Tuvan relations, characterizes the policy of the Tuvan noions towards Russian merchants, determines the role of Chinese capital in the development of Russian trade in Tuva, considers the image of Russian merchant in the view of the Tuvans. In the course of the work, the system approach was used which allows us to consider the object of the study as a set of interrelated elements. The novelty of the study is the involvement of previously unused sources that considered the nature of the relationship between Russian merchants and the Tuvan population in the second half of the 19th - early 20th centuries: the materials of the State Archive of the Irkutsk Region, the Central Archive of the Republic of Tyva, the Scientific Archive of the Manuscript Fund of the Tuva Institute for the Humanities and applied research, the State Archive of the Tomsk Region. The author comes to the conclusion that in the second half of the 19th - early 20th century the Russian-Tuvan relations were contradictory. On the one hand, the Tuvan population that needed goods of Russian merchants showed interest and did not oppose the economic development of the region. Some of the Russian merchants managed to firmly adapt to the Tuvan territory and contact with the local population. On the other hand, the increased inflow of Chinese capital at the beginning of the 20th century, the hostility of the Tuvan noions incited by the Chinese side, as well as the terms of debt trade contributed to the aggravation of Russian-Tuvan economic relations. However, despite numerous difficulties and the unstable situation, Russian merchants managed to maintain their positions in Tuva.
L’Orpheline de Montmartre: A Newly Discovered Novel by Very Popular in Russia Writer
Authors:   Municipal Autonomous Institution Broadcasting Company “Murom Meridian”, Trepetova Elena V.
Published: March 2023

The article presents the history of the search for Louis Boussenard’s novel L’Orpheline de Montmartre undertaken by the author since 2011. The French original of this work was lost, the title is totally unknown to French specialists, and the only evidence of its creation was a pre-revolutionary translation into Russian. The author of the article analyses the translation of E.N. Kiselyov, identifies the narrative elements characteristic of Boussenard, which make it possible to exclude the falsification of authorship, establishes the date of the first publication of the Russian translation, and finds sporadic mentions of this novel in French sources. The analysis of these documents allows to put forward a hypothesis that the novel in question was published in the Parisian daily “La Petite République” and reprinted by an unknown regional socialist newspaper. This hypothesis was exactly confirmed after the digitization in 2015 of the daily socialist newspaper “L’Égalité de Roubaix-Tourcoing.” The result of this discovery was the first book publication of the novel L’Orpheline de Montmartre in French (2017).
S.A. Yesenin’s Diptich about the Sound “Under the Red Elm, the Porch and the Yard...” and “Your Voice is Invisible, Like Smoke in a Hut...”: Context, Poetics, Dating
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Seregina Svetlana A.
Published: March 2023

The article is devoted to the revision of the conditional dating of S.A. Yesenin’s poem “Under the red elm, the porch and the yard...” (1917) accepted in the Complete Works of S.A. Yesenin (1995–2002). The work introduces on evidentiary grounds a number of previously unknown sources of Yesenin’s ideas about the life-creating nature of sound. The study also presents the results of textual analysis of the white autograph of S.A. Yesenin’s poem “Under the red elm, the porch and the yard...”. These searches allowed us to challenge A.A. Kozlovsky’s arguments, who dated the poem “Under the red elm porch and yard...” to 1917, on documentary grounds. The author of the article proposes revise the dating of this work in favor of 1916 on the basis of a comparative analysis with another poem — “Your voice is invisible, like smoke in a hut...” (1916). This analysis demonstrates the artistic-philosophical, metrical and compositional unity of the two works, due to the general context and specific sources. This unity allows us to speak of the poems “Under the red elm, the porch and the yard...” and “Your voice is invisible, like smoke in a hut...” as a diptych created in 1916.
„Ein Wort für junge Dichter“ by I.W. Goethe: On the History of One Interpretation
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Kudryavtseva Tamara V.
Published: March 2023

The article presents a comparative analysis of I.V. Goethe’s “The Word to Young Poets” („Ein Wort für junge Dichter,“ 1833) and the article written in connection with A.M. Gorky death by the theorist of Marxist aesthetics D. (G.) Lukács “The Liberator” („Der Befreier,“ 1936). The subject of the analysis is Lukách’s interpretation of the ‛liberator’ concept used by Goethe in relation to his own work. Lukács, who chose this keyword from Goethe’s paper as the title of his own article, tries within the framework of the theme set by Goethe about the liberating mission of the writer to prove the validity of applying the theses of the German classic in the era of proletarian art. In the course of the undertaken analysis, the author of the article comes to the conclusion about the selectivity of Lukács’s approaches to research material. That was dictated by the specificities of the functional-target settings the author of “The Liberator,” dedicated not just to a great writer per se, but to the classic of socialist realism, was guided by. Therefore, Lukács’s interpretation of Goethe’s text isn’t based on a comprehensive analysis of the German classic and the Soviet writer views on a given topic, but is limited to the juxtaposition of iconic semantic constants that are embedded in the word “liberator,” important for Lukács in terms of their relevance to Gorky’s personality and work.
Complementarity and action mechanisms of Fe2+ activated persulfate and H2O2 system
Authors: Yu Bolun , yao jingjing , Li Haipu , Yang Hui Ying
Published: March 2023

The Fe2+ activated persulfate and H2O2 (Fe2+/KPS/H2O2) system achieved
94% removal of four mixed sulfonamides with 300 s treatment and
possessed excellent complementarity and stability in a wide of pH (3 –
11) and temperature (5 – 65 ℃). The quenching and electron spin
resonance spectrometer results confirmed that sulfate radicals and
hydroxyl radicals coexisted in the coupled system and were responsible
for eliminating sulfonamides under ambient conditions. Experimental
determination and density functional theory calculations demonstrated
that the reaction rate constants of sulfate radicals and hydroxyl
radicals at possible reactive sites distinguished the difference in
removal ratios of four sulfonamides. The removal ratio of sulfathiazole
was higher than others because its calculated reaction rate constants of
sulfate radicals and hydroxyl radicals were higher than those of
sulfamerazine, sulfamethoxazole, and sulfamethazine. The finding
provided a reference for investigating the removal mechanism of mixed
organic pollutants when multiple free radicals coexist.
Phytoremediation As a Way to Clean Technogenically Polluted Areas of Kazakhstan
Authors: Daurov Dias , Zhambakin Kabyl
Published: March 2023

One of the most serious problems worldwide is heavy metal (HM)
pollution. HMs can have a toxic effect on human health and thus cause
serious diseases. To date, several methods have been used to clean
environments contaminated by HMs, but most of them are expensive, and it
is difficult to achieve the desired result. Phytoremediation is
currently an effective and affordable processing solution used to clean
and remove HMs from the environment. This review article discusses in
detail the technology of phytoremediation and mechanisms of HM
absorption. In addition, methods are described using genetic engineering
of various plants to enhance the resistance and accumulation of HMs.
Thus, phytoremediation technology can become an additional aid to
traditional methods of purification.
Production of Ni-Co-bronze composites with different TiC composition by hot pressing
Authors: Imak Anil , Kilic Musa , Kirik Ihsan
Published: March 2023

Improving microstructural, mechanical, and thermal properties of Ni-Co-Bronze composites is crucial for various applications. In this study, five Ni-Co-Bronze (CuSn)+XTiC (0, 3, 7, 10, and 15 wt.%) composites were produced by using the hot pressing method. The effect of TiC reinforcement rate on each of their microstructure, wear, hardness, and thermal properties was investigated. Within the scope of microstructure analysis, the scanning electron microscope (SEM), electron dispersive spectrometer (EDS), and XRD analysis were employed. Thermal analyses were carried out for thermal differences between the samples. Furthermore, microhardness, impact, and wear tests were run to estimate mechanical behaviors of Ni-Co Bronze+XTiC composite. Experimental results indicated that TiC rate had an important effect on the microstructure, wear-resistance and microhardness of Ni-Co bronze composite. As the TiC reinforcement rate increased, the hardness of Ni-Co Bronze+XTiC composites varied between 180 HV and 450 HV. Consequently, microstructure analysis revealed that there was a serious interaction between reinforcement and matrix. Wear resistance increased with a TiC (7-10) wt.% rate but decreased at high TiC rates. It was clearly seen that the wear pattern was both oxidative and abrasive.
Effects of heat treatment on characteristics of Zn substituted Co/Mn ferrite nanoparticles
Authors: Deraz Nasrallah
Published: March 2023

Glycine assisted self-combustion method resulted in fabrication of cobalt-manganese ferrite substituted by zinc (Zn) element. The as- synthesized Zn substituted Co- Mn ferrite was subjected to heat treatment at 600 oC and 800 oC for 2h. Effects of heat treatment on the structural, morphological, surface and magnetic properties of ZnCoMn ferrite were studied. These properties were characterized by using various techniques including TGA-DTGA, FTIR, XRD, SEM, EDX, TEM and VSM. The results showed that the used preparation route led to the formation of nano crystalline Zn0.2Co0.4Mn0.4Fe2O4 particle with cubic spinel type structure. The crystallinity of this ferrite increases as the heat treatment increases. However, the preparation method resulted to the creation of spongy, fluffy, foamy and fragile material with cubic type structure with some agglomerations. Increasing the calcination temperature from 600 oC to 800 oC, led to a decrease in the surface area (39.4 %) of the as- synthesized ferrite. This treatment causes an increase in the magnetization(40.3 %) of this ferrite. The heat treatment that led to various changes in the different properties of the manufactured ferrite was discussed.
The HVAC model predictive control of building thermal dynamic characteristics
Authors: Chi Mingshu , Guo Yizhuo , Yu Kecheng , Zhang Cong , Gao Yuan , Lu Junchen
Published: March 2023

As the terminal energy user of urban power grid, it is significant to model
and simulate the energy consumption characteristics of buildings. First, the
author proposes a thermal dynamic model to predict the energy consumption of
building refrigeration/heating, it is composed of several groups of heat
transient energy balance equations, which can fully consider the impact of
heat convection, heat conduction and heat storage on building energy
consumption during the heat transfer process of building envelope. Then, the
HVAC model predictive control (MPC) method considering the thermal dynamic
characteristics of the building envelope is proposed for the heating,
ventilation and air conditioning, the core energy unit of the building, the
change of window wall ratio in building will affect the thermal insulation
performance of the building, so the window wall ratio in building design
should not exceed 0.7. From the perspective of building thermal insulation
performance, the author analyzes the situation that the total 48 hours
operating cost of buildings under two control methods changes due to the
change of building thermal insulation performance with the change of window
wall ratio in different environments, the simulation results show that when
using MPC control method for HVAC, the daily operating cost of buildings
increases with the window wall ratio at a lower rate than the traditional
control method. It can be seen that the MPC control method has a better
effect of energy saving and reducing the total operating cost of buildings
in response to the environment where the window wall ratio of buildings
increases or the thermal insulation performance of buildings becomes worse
over time. It is proved that the HVAC control method based on MPC not only
helps to reduce the building energy cost, but also deals with the reduction
of HVAC energy efficiency level and the deterioration of building
insulation performance, it is more conducive to saving energy and improving
the operating economy of buildings.
Design and simulation of hybrid thermal energy storage control for photovoltaic fuel cells
Authors: Fang Xiaomin , Li Xiaolu
Published: March 2023

In order to meet the demand of stable and continuous household electricity
con?sumption, the author proposes the modelling and simulation of
photovoltaic fuel cell hybrid power generation system. The system is
composed of photovoltaic power generation device, fuel cell/super
capacitor, electrolytic cell, hydrogen storage device and power regulation
unit. As photovoltaic power generation is affected by sunshine changes, the
combination of fuel cells and super capacitors with photo?voltaic devices
can ensure the stability and reliability of power supply of hybrid power
generation system. Taking sunshine intensity and household electricity
consumption in a certain area as an example, the system is simulated in
MATLAB/SIM?ULINK software. The results show that: At 08:30-17:00, the output
power of the fuel cell is almost zero. This is because the electric energy
output by the photovoltaic power generation system can basically meet the
power demand of users during this period. At 00:00-6:00 and 18:30-24:00, the
sunlight intensity is zero, and the power output of the photovoltaic power
generation system is zero, at this time, the user?s electricity is
completely supplied by the fuel cell. The investment cost of 1 kW fuel cell
is about 45258.4 yuan, and that of 1 kW ordinary battery is about 15200
yuan, the investment cost of fuel cell is still high. In conclusion, the
hybrid power generation system can meet the demand of ordinary household
electricity.
Fault prediction and simulation analysis of ultra-high voltage transmission-line based on thermal energy transformation
Authors: Fu Shixi , Chen Zhihui , Gan Zongyue , Hao Dena
Published: March 2023

In order to solve the traditional long-distance ultra-high voltage (UHV)
transmission-line risk warning system in the design process, it neglects
the classification step of early warning information, which leads to the
poor effect of risk early warning, the authors propose fault prediction and
simulation analysis of UHV transmission-line based on thermal energy
transformation. In the hardware design part, the network video server is
used to design the host control module, and the video decoding chip is used
to convert the acquired analog signal into digital signal, then it is
transmitted to the serial port server, and the risk warning circuit is
designed based on it. In the software design, GA-BP algorithm is used to
obtain the number of nodes in the middle layer, the constraint range is
determined, and the warning information is classified to realize the risk
warning of long-distance UHV transmission-lines. The experimental results
show that the warning accuracy of the system under different conditions is
high, and the highest warning effect can reach 95%. It is proved that the
classification recall rate of early warning information is high, which can
effectively resist interference and provide strong support for the safe
operation of transmission-lines.
Solar heat collection photoelectric tracking servo drive system based on cloud computing
Authors: Wei Huiting
Published: March 2023

In order to solve the problem of high cost and low utilization of solar power
generation, the author proposed a solar heat collection photoelectric
tracking servo drive system based on cloud computing. By establishing the
MATLAB/SIMULINK simulation mathematical model of PID and adaptive fuzzy PID
control in the core controller PLC, the authors compare and analyze the
response characteristics of the tracking control system under different
control strategies under the action of unit step signal and disturbance. The
experimental results show that the overshoot of the adaptive fuzzy PID
control algorithm is very small, almost zero, the response speed is the
fastest, the transition time is the shortest, the system reaches stability
at about 0.02 second. In conclusion the tracking control system of solar
concentrator under adaptive fuzzy PID control not only has good tracking
control accuracy, but also has the advantages of strong anti-interference
ability and good stability, which greatly improves the comprehensive
performance of the tracking control system of solar concentrator.
Thermal energy modelling system for green energy application of exterior wall under smart home building
Authors: Hu Jun
Published: March 2023

In order to solve the problem of poor heat storage capacity of traditional
thermal insulation materials, the author proposed a building thermal
simulation study of PCM wall under smart home buildings. The author chose
urea-formaldehyde resin microcapsule with 60% mass fraction of paraffin as
the research object, and gave the structure of the study wall. After
determining the physical parameters of PCM, the phase change wall is
simulated and analyzed, and the simulation results are compared with the
experimental results used to verify the accuracy of the model. The internal
temperature of phase change wall and reference wall, and the internal and
external wall temperature of four-way wall were compared and analyzed by
using the simulation results. The results show that the internal wall
temperature of the reference wall in four directions increased with time
after the 54th hour, reached the peak temperature at the 65th hour, and then
the internal wall temperature decreased with time, however, the internal
wall temperature in four directions began to rise with time after the 56th
hour of phase transition wall, and decreased with time after the 70th hour,
this indicates that there is always hysteresis of temperature rise/fall in
the inner wall of PCM wall, indicating the thermal inertness of PCM heat
transfer. The changes of exterior wall temperature are similar to that of
exte?rior wall temperature. With the increase/decrease of outdoor
temperature, exterior wall temperature increases/decreases. However, the PCM
exterior wall temperature curve is higher than the reference wall (ordinary
gypsum layer) inside the wall temperature curve, indicating that the PCM
exterior wall temperature is higher than the reference wall exterior wall
temperature. The heat transfer between inside and outside walls of building
is consistent with the outdoor temperature, but the heat transfer speed of
phase change wall is slow due to the heat storage function, which proves
that PCM in the structure is thermal inert and capable of heat stor?age.
Automatic storage of building thermal energy and heat pump heating based on wireless communication
Authors: Zhang Le
Published: March 2023

By means of ZigBee wireless communication technology and heat pump heating
technology, the author reduces energy consumption, solve the problem of
large energy consumption of building heat pump heating at present. Firstly,
the characteristics and applications of ZigBee wireless technology in the
system design are adopted, and its protocol stack structure and topology are
analyzed, respectively, select your own network structure according to the
characteristics of this system. According to its structural characteristics,
the overall design of the heat pump wireless control system is designed.
Secondly, by installing the heating trans?mission and distribution system
controller, the pressure loss in the system loop is overcome, and the zero
differential pressure control point is selected to control the throttling
resistance loss of all heat users, start the heating system unit in the
building to realize the application of heat pump heating system in the
building. Through three experimental tests, the maximum energy consumption
of the system in 24 hours application is 9.99 kWh, the minimum energy
consumption is 9.53 kWh, and the average energy consumption is 9.7 kWh, the
energy consumption in building application is relatively stable, low energy
consumption, and good practicability. The adoption of ZigBee wireless
communication technology will improve the operation mode of heat pump
heating system and improve the automation level and performance of the
system.
Building energy consumption simulation and its application in underground-water source thermal energy management system
Authors: Wang Qianhua , Chen Hao , Zhu Hongyu
Published: March 2023

In order to analyze the rationality of the compound well structure and the
degree of heat penetration of groundwater in a groundwater ground source
heat pump project in a certain district of a city, the author proposed a
method for building energy consumption simulation and groundwater flow
numerical model. The variation trend of groundwater temperature under
different heat transfer temperature difference is simulated and predicted.
The experimental results show that the fitting points where the error
between the simulated predicted temperature and the actual measured
temperature does not exceed 0.5?C account for 51.7%, the fitting points
where the error is 0.5~1?C account for 28.7%, the fitting points where the
error is 1~2?C account for 18.1%, and the fitting points where the error is
greater than 2?C account for 1.5%. The dynamic change trend of the simulated
predicted temperature curve is basically consistent with that of the actual
measured temperature curve. It is proved that the building energy
consumption simulation and the numerical model of groundwater flow can
effectively analyze the rationality of the compound well structure of the
groundwater ground source heat pump project and the degree of groundwater
heat penetration.
Effect of composite polystyrene granular thermal insulation mortar on thermal energy storage of building energy consumption
Authors: Wei Chenghui , Chen Hao , Li Haiqiang
Published: March 2023

In order to save energy and reduce building energy consumption, the author
pro?posed a study on the impact of composite polystyrene particle thermal
insulation mortar on building energy consumption and thermal energy storage,
take the ETIRS-C residence as the research object, through simulation
calculation under different insulation mortar thickness, analyze the
relationship between insulation thickness and energy consumption and thermal
environment. According to the simulation calculation of room temperature,
horizontally, the thickness of thermal insulation mortar in air conditioning
season is not sensitive to the natural room temperature, there is a certain
sensitivity to the natural room temperature in the heating season, in the
longitudinal direction, the 30 mm thick insulation mortar is the jumping
point, and the increase of the thickness of insulation mortar has no obvious
effect on the natural room temperature. According to the simulation
cal?culation of room energy consumption, the thickness of thermal insulation
mortar is about 20 mm, and both heat and cold consumption have achieved good
thermal insulation and energy saving effect, further increasing the
thickness of thermal insulation mortar will have limited impact on energy
consumption, which may be uneconomical and increase the cost and
construction difficulty. Therefore, based on the aforementioned results, it
can be considered that the thickness of thermal insulation mortar should
preferably be controlled within 20-30 mm.
Theoretical and experimental research on the thermal energy management system of direct expansion solar heating
Authors: Yu Weifang
Published: March 2023

The author has established the experimental device of the direct expansion
solar heat pump system. In this device, the bare plate solar collector is
also used as a heat pump evaporator. Under the sunny weather in May, the
author conducted an experimental study on the heat pump system. The
experimental results show that during the whole experiment, the COP, and the
heat collection efficiency of the system reached 2.50-3.35 and 50.0-75.2%,
respectively. At the same time, the influence of solar irradiance,
condensation temperature and other parameters on the COP and heat collection
efficiency of the system is analyzed and discussed, so as to provide some
reference for the application of the system.
Type 1 Diabetes Continuous Glucose Monitoring Use in the Pediatric Emergency Department Affects Laboratory Test Frequency but Not Treatment Timing
Authors: Baker Rachel K. , Filipp Stephanie L. , Jacobsen Laura M.
Published: March 2023

Regular use of continuous glucose monitoring (CGM) in type 1 diabetes management increases the achievement of glycemic targets and reduces health care utilization, specifically emergency department (ED) visits. This retrospective chart review examined the effects of CGM use in patients with type 1 diabetes in a pediatric ED. Use of CGM was associated with several differences in patient management in the ED. This work is a first step toward development of guidelines for the appropriate use of CGM in the pediatric ED. In the future, CGM use in type 1 diabetes may lead to reduced ED-specific health care costs.
Novel Once Weekly Basal Insulin Fc (BIF) Achieved Similar Glycemic Control with A Comparable Safety Profile Versus Insulin Degludec in Patients with Type 1 Diabetes (T1D)
Authors: Kazda Christof M. , Bue-Valleskey Juliana M. , Chien Jenny , Zhang Qianyi , Chigutsa Emmanuel , Landschulz William , Wullenweber Paula , Haupt Axel , Dahl Dominik
Published: March 2023

  

Objective

Basal Insulin Fc (BIF; insulin efsitora alfa; LY3209590), a fusion protein combining a novel single-chain insulin variant with a human IgG Fc domain, is designed for once weekly basal insulin administration. This Phase 2 study assessed safety and efficacy of BIF versus degludec in N=265 patients with type 1 diabetes (T1D) using multiple daily injections.

Research Design and Methods

During this randomized, parallel, open-label study, patients with T1D were randomized (1:1) to receive BIF once weekly or degludec once daily over the 26-week treatment period. Both groups were titrated to fasting glucose 80-100 mg/dL. Primary endpoint was HbA1c change from baseline to Week 26 (non-inferiority margin=0.4%). Secondary endpoints included percent time in range (TIR, 70-180 mg/dL), CGM fasting glucose (FG), and rate of hypoglycemia.

Results

After 26 weeks, BIF demonstrated non-inferior HbA1c change from baseline versus degludec with a statistically significant treatment difference of 0.17% (90% CI=0.01, 0.32; p=0.07) favoring the comparator. Percent TIR was similar for BIF (56.1%) and degludec (58.9%; p=0.112) at Week 26. FG values were significantly higher for BIF (158.8 mg/dL) versus degludec (143.2 mg/dL; p=0.003). Rates of CGM-derived hypoglycemia were not statistically significantly different for BIF and degludec over 24 hours for Level 1 (p=0.960) or Level 2 (p=0.517) during the treatment period. Occurrence of serious adverse events was similar between BIF and degludec.

Conclusions

Once weekly BIF demonstrated non-inferior glycemic control to once daily degludec (treatment difference: 0.17% favoring degludec) and no difference in hypoglycemia or other safety findings in patients with T1D.
Operation Parameters Variation of Air Source Heat Pump According to the Outdoor Temperature
Authors: SEZEN Kutbay
Published: March 2023

Air source heat pumps (ASHP), known as energy efficient systems, emerge as environmentally friendly and economical solutions for building heating. Unfortunately, the operating parameters of ASHPs and accordingly their performance are directly affected by the daily and seasonal temperature changes of the outside air. In this study, change in operation parameters of a selected ASHP with 3.4kW nominal heating capacity is investigated with a calculation method based on the logarithmic mean temperature difference, between -10°C to 18°C outdoor temperature range with 2°C steps, at constant compressor power. The study is verified with published COP data of the manufacturer. Results are shared with graphs that give the variation of refrigerant evaporation and condensation temperature and pressure, COP, and condenser heating load according to outdoor air temperature. A raise from -10°C to 18°C in outdoor temperature, increases the COP value from 3.38 to 5.49. Detection of the increase in evaporation pressure in parallel with the outdoor temperature may allow easy control of the refrigerant charge level with a manometer. This study can be a useful guide for researchers who aim to determine the outdoor temperature dependent operating parameters of an ASHP and for technical personnel who need this information in fields.
Musik zur Förderung fremdsprachlicher Kompetenzen: Einblicke in den Forschungsstand mit einem Exkurs in die romanischen Sprachen
Authors: Willems Aline
Published: March 2023

Integrating music into foreign language teaching is not a new phenomenon, but has been considered a standard approach to promoting linguistic and intercultural competences in learners for decades. However, the most recent research shows that music, and especially making music by oneself, can have numerous other influences on foreign language learners, most of which are referred to as ‘transfer effects’. This article examines both the transfer effects of active music making on the promotion of communicative and intercultural competences as well as on other personality traits that can support foreign language learning. The results of several studies are critically reflected and further research is encouraged. In the final section, it is highlighted how the learning of Romance languages in particular can benefit from a connection to making music.
Slam Poetry and Poetry Slams im Fremdsprachen- unterricht: Erleben, Analysieren, selbst Verfassen und Präsentieren
Authors: Hille Almut
Published: March 2023

Slam poetry and poetry slams position a performative act at the forefront of the foreign language classroom, and thereby present numerous possibilities for linguistic, cultural and artistic teaching and learning. This allows for a form of applied language to be learned and experimented with that draws attention to the receptive and interpretive possibilities of the utterances as well as to the aesthetic dimensions of texts and the media of their presentation. Slam poetry in the foreign language classroom can enable immediate impressions and interactions, most typically among young slammers, and encourage closer analysis of texts, their performance, and the media involved in their performance. Slam poetry can also encourage students to create and perform their own texts. Such assignments promote basic communicative competencies as well as individual skill sets. This contribution will articulate these aspects on the basis of recent research on slam poetry and poetry slams in the foreign language classroom. It will also cover newer empirical studies of the successes of performative pedagogies, of poetic practice with spoken poems, and of learning to recite poetry in a foreign language. An example of such a praxis will show how learners can compose their own slam poetry and present their poems in (public) poetry slams that they organize themselves or in self-produced poetry videos.