bluuebunny/crossref_metadata_2025 huggingface dataset:
ENSINANDO A TRANSGREDIR
Authors: Macambira Leidiane dos Santos Aguiar , Fernandes Kelly Meneses , Souza Alves Ferreira Alana , Souza da Silva Larissa
Published: May 2023

O presente artigo consiste em um estudo teórico sobre as condições de formação de mulheres negras licenciandas em Biologia como professoras antirracistas, e como as opressões de gênero e raça que interseccionam as histórias de diferentes mulheres podem ser articuladas para pensarmos seus processos formativos. Inspirando-nos na experiência de um Projeto de Extensão, discutimos como a constituição de um grupo de estudos, a contribuição de intelectuais negras, e exercícios de escritas, podem possibilitar a formação de professoras negras antirracistas no ensino de biologia. Consideramos, com estudo, que as intersecções entre gênero e raça nos permitem enxergar caminhos possíveis na formação de mulheres negras e professoras antirracistas no ensino de biologia.
SENTIDOS SUBJETIVOS SOBRE SEXUALIDADE MOBILIZADOS E CONSTRUÍDOS POR ESTUDANTES DO ENSINO MÉDIO EM SALA DE AULA
Authors: Miranda Pedro
Published: May 2023

A sexualidade é um fenômeno essencialmente humano, complexo e subjetivo, desenvolvido nas relações interpessoais do cotidiano. O objetivo da pesquisa foi compreender aspectos de como estudantes de uma escola pública, subjetivam questões relacionadas à sexualidade, em práticas dialógico-problematizadoras. As informações foram produzidas por meio de conversações, complemento de frases e outros e a análise dos dados foi realizada com base na Epistemologia Qualitativa proposta por González Rey. Para vários/as participantes da pesquisa, a sexualidade era sinônimo de órgãos genitais e/ou relação sexual. Com o trabalho pedagógico os/as participantes da pesquisa passaram a compreender a sexualidade como afeto, prazer e bem-estar de um abraço ou estar com os/as amigos/as, além de outros modos de expressão e vivência da sexualidade.
“É PRECISO ESTARMOS ATENTOS E FORTES”:
Authors: Barbosa dos Santos Thiago , Dutra-Pereira Franklin Kaic , Bortolai Michele
Published: May 2023

Este trabalho analisa os estudos acadêmicos sobre gênero e sexualidade apresentados nos anais dos Encontros Nacionais de Ensino de Química (ENEQ). Utilizamos para o levantamento de dados os termos: gênero e sexualidade. Para análise e discussão dos dados, utilizamos o referencial crítico e a Análise de Conteúdo (BARDIN, 2016). Foram encontrados seis trabalhos completos e sete resumos que atendiam ao interesse da pesquisa. O estudo possibilitou reunirmos variadas perspectivas sobre sua importância na Educação Básica, bem como novos horizontes de introduzir o ensino de gênero e sexualidade no ensino de química. Entretanto, ainda assim, são estudos insipientes e que necessitam de maior debate e de políticas públicas que fortaleçam a formação de professores que ousam ensinar Química em tempos que é necessário estarmos “atentos e fortes”.
EPISTEMOLOGÍAS DECOLONIALES Y FEMINISTAS
Authors: Polanco Zuleta Mara Karidy
Published: May 2023

El presente artículo reflexiona sobre las diferentes críticas que se realizan desde los estudios decoloniales y feministas a la epistemología occidental, exponiendo las denuncias sobre el eurocentrismo, el androcentrismo, el racismo y sexismo epistémico, la objetividad, la universalidad, la racionalidad, la naturalización y el binarismo; y el subtextos de género y de raza que hay detrás de estos. Con el propósito de que los y las profesoras de ciencias reflexionemos sobre los sesgos que podemos estar reproduciendo en nuestro quehacer docente si no tenemos en cuenta que ciencia aprendemos y enseñamos.
CONCEPCIONES DE ESTUDIANTES DE EDUCACIÓN SECUNDARIA SOBRE REPRODUCCIÓN Y SEXUALIDAD AL INTERIOR DE DOS INSTITUCIONES EDUCATIVAS EN EL SUR DE COLOMBIA
Authors: Bustos Ayde Lavao , Mosquera Jonathan Andrés , Anacona Matthew Alejandro Cano
Published: May 2023

La imagen que se hace visible sobre los temas de sexualidad y reproducción en las clases de clase ha sido teñida por un enfoque heteronormativo y patriarcal. De esta forma, se han identificado las concepciones de 84 estudiantes de octavo grado de primaria en las instituciones educativas oficiales de la región sur de Colombia, en torno a temas relacionados con la reproducción y la sexualidad. Para él, en el marco de un estudio de naturaleza cualitativo; Se aplicó un cuestionario con preguntas abiertas estructurado en Preguntas Socio-Científicas para abordar temas como la menstruación, la intersexualidad, la dualidad sexogenérica, el desarrollo hormonal y el incesto. Los resultados muestran posturas de pensamiento enmarcadas en un modelo de prevención de riesgos para la Educación Sexual.
APRESENTAÇÃO DO DOSSIÊ
Authors: Marin Yonier Alexander Orozco , Mosquera Jonathan Andrés
Published: May 2023

A América Latina insiste em lutar. Insiste em se levantar diante de séculos de violência. E as questões de gênero e sexualidade reclamam também seu lugar nessas lutas. O mundo inteiro escutou, aprendeu e replicou das lutas feministas chilenas em 2017, 2018 e 2019, inundando as ruas de movimentos sociais exigindo uma transformação social feminista e para a diversidadesexual e de gênero, mexendo com toda a estrutura social. Considerando essas lutas que fazem tremer as bases da luta no contexto latinoamericano, qual o papel que tem a escola? Qual o papel que tem a ciência? Qual o papel que tem o ensino das ciências naturais na escola? Quais as denúncias, constatações, anúncios e caminhos percorridos para a inserção das questões de gênero e sexualidade na educação científica em contextos da América Latina? Estamos acompanhando a luta que grita, exige, acolhe, desestabiliza e faz presença nas estruturas sociais e nos movimentos sociais? Quais são as nossas particularidades nessa interseção? Atendendo a essas perguntas, trazemos o dossiê intitulado “Gênero e Sexualidade na Educação Científica: Perspectivas na América Latina”. Este dossiê propõe uma discussão modesta, mas plural e potente ao redor dessas perguntas com trabalhos de pesquisa, experiências, relatos e artes que dialogam desde Brasil, Chile, Colômbia e México. Partimos de reconhecer que as questões de gênero e sexualidade no ensino de ciências, geralmente associadas à Educação para a Sexualidade ou Educação para a Saúde ou em Saúde, constituem um campo que apresenta desafios e resistências na América Latina
GÉNERO Y BIOLOGÍA, CULTURA Y NATURALEZA
Authors: Marin Yonier Alexander Orozco , Manus Siobhan Guerrero
Published: May 2023

Siobhan Guerrero Mc Manus es bióloga, filósofa e investigadora del Centro de Investigaciones Interdisciplinarias en Ciencias y Humanidades de la Universidad Autónoma de México (UNAM) y ha publicado libros como “¿Naces o te haces? La ciencia detrás de la homosexualidad” (2013), “Fragmentos: cuatro ensayos de pensamiento ambiental” junto con Agustín Mercado (2020) y “Materialidades semióticas. Ciencia y cuerpo sexuado” el cual coordinó con Lu Ciccia (2022). Siobhan, además es reconocida por su amplia producción teórica sobre la filosofía de la biología y los abordajes post-dualistas en el campo y sus reflexiones sobre la diversidad sexual y de género desde las discusiones académicas y los activismos contemporáneos.
FEMINISMOS QUE “EMPIEZAN A SER CARNE”
Authors: Marin Yonier Alexander Orozco , González Johanna Patricia Camacho
Published: May 2023

La Profesora Doctora Johanna Patricia Camacho Gonzalez, Licenciada en Química, Magister en Docencia de la Química, Doctora en Ciencias de la Educación y profesora asociada de la Facultad de Filosofía y Humanidades de la Universidad de Chile, expresidente de la Sociedad Chilena de Educación Científica y una de las investigadoras más destacadas a nivel latinoamericana en relación a la formación de profesoras y profesores con perspectiva de género. Aprovechando su trayectoria en estas discusiones, conversamos sobre los desafíos para “hacer carne” las teorías críticas feministas en la formación de profesoras y profesores de ciencias naturales, y en los contextos escolares. En esta entrevista transitamos por las contribuciones de los feminismos a las ciencias naturales y su enseñanza, el problema del dualismo entre formación disciplinar científica y formación pedagógica y didáctica para la inclusión de estas perspectivas, los obstáculos y potencialidades para la formación inicial y continuada, así como perspectivas de interseccionalidad en el contexto chileno.
Spectrum of Gender Self-Presentations among Women Candidates
Authors: Aronson Pamela , Oldham Leah , Lucas Emily
Published: May 2023

In the 2018 U.S. midterm elections, Democratic women, especially those from diverse racial and ethnic backgrounds, were elected in record numbers. Drawing on qualitative website and Twitter bio data, this paper examines twenty key races at varying levels that had women candidates. We extend our previously-developed typology of gender self-presentations by classifying these approaches on a spectrum, ranging from gender traditional on one side to feminist on the other (with gender neutral and gender nontraditional in the middle). Illustrating the utility of this typology by applying it to a variety of races in the 2018 U.S. midterm elections, we extend prior work and suggest that gender nontraditional and feminist self-presentations highlight women candidates’ power and agency.
Persistence of SARS-Cov-2 Igg Antibody Response among South African Adults: A Prospective Cohort Study
Authors: Adeniyi Oladele Vincent , Durojaiye Oyewole Chris , Masilela Charity
Published: May 2023

This study assesses the durability of severe acute respiratory coronavirus-2 (SARS-CoV-2) anti-nucleocapsid (anti-N) immunoglobulin G (IgG) after infection, and examines its association with established risk factors among South African healthcare workers (HCWs). Blood samples were obtained from 390 HCWs with diagnosis of coronavirus disease 2019 (COVID-19) for assay of the SARS-CoV-2 anti-N IgG at two time points (Phase 1 & 2) between November 2020 and February 2021. Out of 390 HCWs with COVID-19 diagnosis, 267 (68.5%) had detectable SARS-CoV-2 anti-N IgG antibodies at the end of phase I. These antibodies persisted for 4-5 and 6-7 months in 76.4% and 16.1%, respectively. In the multivariate logistic regression model analysis, black participants were more likely to sustain SARS-CoV-2 anti-N IgG for 4-5 months. However, participants who were HIV positive were less likely to sustain SARS-CoV-2 anti-N IgG antibodies for 4-5 months. In addition, individuals who were <45 years of age were more likely to sustain SARS-CoV-2 anti-N IgG for 6-7 months. Of the 202 HCWs selected for phase 2, 116 participants (57.4%) had persistent SARS-CoV-2 anti-N IgG for an extended mean period of 223 days (7.5 months). Findings support the longevity of vaccine responses against SARS CoV-2 in black Africans.
Unlocking the Beat: Dopamine and eyeblink response to classical music
Authors: Riby Leigh martin , Fenwick Sam , Kardzhieva Dimana , Allan Beth , McGann Deborah
Published: May 2023

The present study examined music-induced dopamine release, as measured by a proxy measure of spontaneous eye blinks. Specifically, we explored the effects of uplifting and sombre tones in different sections of Vivaldi's Four Seasons to investigate the affective content of musical pieces within one composition. Seventeen participants listened to four concertos (Major modes: Spring, Autumn, Minor modes: Summer and Winter) and a silence condition while completing the 3-Stimulus Odd-ball attention task. Electrooculograms were recorded from electrodes placed above and under the left eye. Self-reported arousal and music preference measures were also gathered during the testing session. In addition, the P3a Event-Related Potential (ERP) component was analysed as another potential index of dopamine function. Results revealed significant differences in the blink rates during music listening and silence, with the largest effect observed for the sad, melancholic Winter concerto. However, no significant correlation was found between blink rate and music preference or arousal. Furthermore, no reliable association was found between blink rate and the P3a ERP component, suggesting that these measures tap into different aspects of dopamine function. These findings contribute to understanding the link between dopamine and blink rate, particularly in response to classical music. Crucially, the study's discovery that the Winter concerto, with its sorrowful tone, significantly increased the blink rate highlights the significance of sad music and perhaps the programmatic qualities of this concerto to induce a strong emotional response.
Accumulation model and lithologic reservoir formation in continental fault basin A case study of the Lithologic Reservoir of Nantun Formation in Tanan Sag, Mongolia
Authors: Liu ShaoJun , Zhao Shengxian , Yang Xuefeng , Zhang Jian , Yin Meixuan , Meng Qian , Li Bo , Xia Ziqiang
Published: May 2023

According to the structural features, sedimentary evolution, types of sedimentary facies, source rocks features, diagenesis evolution, reservoir features and hydrocarbon formation mechanism, exploration status and hydrocargon resource potential, this article analyzed the major control fac-tors and hydrocarbon distribution rules of the lithologic reservoirs in continental fault basin. The research shows that three major control factors and one coupled factor (fractures act as a tie) in-fluence hydrocarbon formation of lithologic traps in Nantun Formation of Tanan Sag, which in-clude sand body types, effective source rocks and effective reservoirs. With the increase in depth, enough hydrocarbon generate in source rock under thermal evolution. Hydrocarbon generation and expulsion are more intensive when it comes to the depth threshold and critical conditions of hydrocarbon supplying are met. Traps that surrounded or contacted by source rock, or communi-cated by fault are qualified to form reservoirs. As buried depth increases, hydrocarbon genera-tion-expulsion intensity grows and the trap is more petroliferous. Hydrocarbon accumulation and reservoir formation are also controlled by sandbody accumulation conditions. When it meets the critical conditions of hydrocarbon generation and concrete oil and gas are charged in, better phys-ical properties of sandbody always indicate more hydrocarbon accumulation in the trap. Alloca-tion of sand type, effective source rock and effective reservoir is optimized under the effect of fractures, and coupled hydrocarbon reservoir with these three elements.
A Novel Approach to Treat Peripheral Artery Disease
Authors: Blum Arnon
Published: May 2023

Atherosclerosis is a dynamic, chronic and progressive process that involves the vascular bed (coronary and peripheral). Risk factors are associated with the progression rate and with the evolution of atherosclerosis. There are traditional risk factors and non-traditional risk factors, all of them lead to endothelial dysfunction. Endothelial dysfunction plays a key factor in atherosclerosis. It accompanies hypercholesterolemia, diabetes, hypertension, cigarette smoking – leading to the development of atherosclerosis. Endothelial dysfunction can be reversed by treating hyperlipidemia and other damaging processes, and the mechanism is believed to be associated with an increase in vascular endogenous NO. PAD is a devastating disease, leading to leg pain and amputation. Until now the optional treatments don’t cure or prevent the uneventful outcome, but may slow the downhill progression.

We summarize the updated knowledge of the management of PAD and suggest a novel approach to treat patients with PAD, using stem cells technology and a special novel endovascular device that will deliver the cells continuously on the long run and may halt the progression of atherosclerosis or even cure PAD.
Polymorphisms of the GCLC Gene Are Novel Genetic Markers For Susceptibility To Psoriasis Associated With Alcohol Abuse And Cigarette Smoking
Authors: Efanova Ekaterina , Bushueva Olga , Saranyuk Roman , Surovtseva Anna , Churnosov Mikhail , Solodilova Maria , Polonikov Alexey
Published: May 2023

The aim of this pilot study was to investigate whether single nucleotide polymorphisms (SNP) in the gene encoding the catalytic subunit of glutamate cysteine ligase (GCLC) are associated with the risk and clinical features of psoriasis. A total of 944 unrelated individuals, including 474 patients with a diagnosis of psoriasis and 470 healthy controls, were recruited for the study. Six common SNPs in the GCLC gene were genotyped using the MassArray-4 system. Polymorphisms rs648595 (OR=0.56 95%CI 0.35-0.90, Pperm=0.017) and rs2397147 (OR=0.54 95%CI 0.30-0.98, Pperm=0.05) were associated with susceptibility to psoriasis in males. In the male group, diplotype rs2397147-C/C×rs17883901-G/G was associated with decreased risk of psoriasis (FDR-adjusted P=0.014), whereas diplotype rs6933870-G/G×rs17883901-G/G (FDR-adjusted P=0.045) showed association with increased disease risk in females. Joint effects of SNPs with tobacco smoking (rs648595 and rs17883901) and alcohol abuse (rs648595 and rs542914) on the risk of psoriasis were observed (Pperm≤0.05). Furthermore, we found multiple sex-independent associations between GCLC gene polymorphisms and various clinical features such as earlier disease onset, the psoriatic triad, and specific localizations of skin lesions. The present study is the first to show that polymorphisms of the GCLC gene are significantly associated with the risk of psoriasis and related to its clinical features.
Does the Number of Loops Affect the Results of Barbed Pharyngoplasties? A Retrospective Comparison in Two Centers
Authors: Carrasco-Llatas Marina , Martínez-Ruiz de Apodaca Paula , González-Turienzo Elena , Martínez-Moreno Miguel , Domínguez-Celis Felipe , Cammaroto Giovanni , Vicini Claudio
Published: May 2023

Background: The use of barbed sutures for pharyngoplasty techniques is a new trend in sleep apnea surgery, but little is known about its short-term results depending on the different techniques. The objective of this study was to compare the surgical results in two different centers using barbed sutures in which the main difference was the loops performed in the soft palate. Methods: This is a retrospective study of patients with obstructive sleep apnea (OSA) operated in two centers. A statistical analysis comparing the ENT department of the Ospedale Morgagni-Pierantoni from Forlí with the ENT department of Dr. Peset University Hospital was performed. Results: The final sample size was 138 patients (70 from Forlí and 68 from Valencia). In both series, a significant improvement was observed in OSA patients with significant reductions in respiratory events not related to weight reduction. The mean delta Apnea-Hypopnea index was 13.36 (SD 21.3) in Forlí and 22.8 (SD 22.05) in Valencia (p<0.05). Forlí’s series had a higher proportion of multilevel surgeries than Valencia's and a lower proportion of tonsillar hypertrophy. Conclusion: The number of loops performed in the soft palate may improve the surgical results, nevertheless, this must be confirmed in prospective studies.
Empirical Study on the Key Influencing Factors and Development Mechanisms for the Sustainability of Microfinance Institutions based on the Survey of Chinese Microcredit Companies
Authors: Li Jiming , Li Xiaoxi , Wang Jile
Published: May 2023

Microfinance institutions (MFIs) play an significant role in financial inclusion and poverty alleviation activities. A critical challenge facing MFIs is how on all to build its own capacity for sustainable and healthy development. By using the data from the pilot survey of 65 microcredit companies in Zhejiang of China, this paper explores the factors affecting MFIs activities by principal component analysis and analyzes the key Influencing factors and sustainable development performance with the analysis of variance and multi-regression model.The results indicate that four key factors of operational technology, external environment, financial condition and institution size have a significant positive effect on the economic sustainability performance of MFIs, while the adjusted institution size is insignificant positive effect on operational sustainability performance,which means that key factors of MFIs sustainability have a greater impact on economic sustainability performance than operational sustainability performance.
Externally Applied Electromagnetic Fields and Hyperthermia Irreversibly Damage Cancer Cells
Authors: Obrador Elena , Jihad-Jebbar Ali , Salvador-Palmer Rosario , López-Blanch Rafael , Oriol-Caballo María , Moreno-Murciano María Paz , Navarro Enrique , Cibrian Rosa , Estrela José M.
Published: May 2023

At present, the applications and efficacy of non-ionizing radiations (NIR) in oncotherapy are limited. In terms of potential combinations, the use of biocompatible magnetic nanoparticles as heat mediators has been extensively investigated. Nevertheless, the development of more efficient heat nanomediators that may exhibit high specific absorption rates still is an unsolved problem. Our aim was to investigate if externally applied magnetic fields and a heat-inducing NIR affect tumor cell viability. To this end, under in vitro conditions, different human cancer cells (A2058 melanoma, AsPC1 pancreas carcinoma, MDA-MB-231 breast carcinoma) were treated with the combination of electromagnetic fields (EMFs, using solenoids) and hyperthermia (HT, using a thermostated bath). The effect of NIR was also studied in combination with standard chemotherapy and targeted therapy. An experimental device combining EMFs and high intensity focused ultrasounds (HIFU)-induced HT was tested in vivo. EMFs (25 T, 4h) or HT (52C, 40 min) showed a limited effect on cancer cell viability in vitro. However, their combination decreased viability to approx. 16%, 50%, and 21% of controls values in A2058, AsPC1, and MDA-MB-231 cells, respectively. Increased lysosomal permeability, release of cathepsins into the cytosol and mitochondria-dependent activation of cell death are the underlying mechanisms. Cancer cells could be completely eliminated combining EMFs, HT and standard chemotherapy or EMFs, HT and anti-Hsp70-targeted therapy. As a proof of concept, in vivo experiments performed in AsPC1 xenografts showed that combination of EMFs, HIFU-induced HT, standard chemotherapy and a lysosomal permeabilizer induces a complete cancer regression.
Application Regarding E-Government Use in Local Government of Nigeria
Authors: Oludu Oluwafemi Victor , Karagozlu Damla , Kaya Tugberk
Published: May 2023

Communication and effective interactions are inevitable necessities in every organizational setting. In this era of information and communication technology, where limitations and difficulties in proper communication and interactions between different entities of various organizations have been reduced maximally, the government, stakeholders, and citizens of the different nations should also utilize these available tools in a way to improve the maximum performance in governance through interactions and e-participation between the citizens, stakeholders, and the government parastatals. This research focuses on examining the available and most preferred applications or platforms which encourage the best level of communication and interaction through E-participation among the citizens, stakeholders, and government from the local government lev-el taking Nigeria as a case study
Compact UHF Circularly Polarized Multi-band quadrifilar antenna for CubeSat
Authors: Nguyen Manh Thao , Ferrero Fabien , Huy Trinh Le
Published: May 2023

This article presents a wide-band antenna designed for the Cube Satellite (CubeSat). Based on a quadrifilar structure, the antenna provides circular polarization radiation, which is suitable for satellite communication. Moreover, the antenna is designed and fabricated using two 1.6 mm thickness FR4-Epoxy boards that connect together by the metal pins. In order to improve the robustness, a ceramic spacer is placed in the centerboard, and four screws at the corners are added to fix the antenna with the CubeSat structure. These additional parts reduce antenna damage caused by vibrations in the launch vehicle lift-off stage. The proposal has a dimension of 77mm x 77mm x 10mm and covers the LoRa frequency bands of 868 MHz, 915 MHz, and 923 MHz. According to the measurements in an anechoic chamber, antenna gains are obtained with the values of 2.3 dBiC and 1.1 dBiC for the 870 MHz and 920 MHz, respectively. Finally, the antenna is integrated into a 3U CubeSat that was launched by a Soyuz launch vehicle. The terrestrial-to-space communication link was measured, and the antenna performance was confirmed in the real-life scenario.
Impact of National Tobacco Control Policy on Rates of Hospital Admission for Pneumonia: When Compliance Matters
Authors: Gambaryan* Marine , Kontsevaya Anna , Drapkina Oxana
Published: May 2023

Number of studies claim that tobacco control (TC) regulations are associated with reductions in smoking-related hospitalisation rates, however very few have estimated the impact of TC laws (TCL) at both countrywide and regional levels, and none of them - in relation to compliance with TC regulations. This study evaluates the effects of Russian TCL on hospital admission (HA) rates for pneumonia countrywide and in 10 Russian regions and the extent of these effects in connection with the compliance to TCL. Methods: HA rates for pneumonia during 2005–2019 were analysed to compare the periods before and after the adoption of TCL in 2013. An interrupted time series design and a Poisson regression model were used to estimate the immediate and long-term effects of TCL on pneumonia annual hospitalisation rates after the TCL adoption, compared with the pre-law period. The 10 Russian regions were compared using the TCL Implementation Scale (TCIS) developed on the basis of the results of Russian TC policy evaluation survey; Spearman’s rank correlation and linear regression models were employed. Results showed a 14.3% reduction in HA rates for pneumonia (RR 0.88; p=0.01) after the adoption of TCL in Russia with significant long-term effect after 2013 (RR 0.86; p=0.006). Regions with better enforcement of TCL exhibited greater reductions in pneumonia HA rates (rsp=−0.55; p=0.04); (=−4.21; p=0.02). Conclusions: TCL resulted in a sustained reduction in pneumonia hospitalisation rates, but these effects, varying by region, may depend on the scale of the TCL enforcement.
Immuno-Contexture and Immune Checkpoint Molecule Expression in Microsatellite Stable/Mismatch Repair Proficient Colorectal Carcinoma
Authors: Giacomelli Mauro , Monti Matilde , Pezzola Diego Cesare , Lonardi Silvia , Bugatti Mattia , Missale Francesco , Cioncada Rossella , Melocchi Laura , Giustini Viviana , Villanacci Vincenzo , Baronchelli Carla , Manenti Stefania , Imberti Luisa , Giurisato Emanuele , Vermi William
Published: May 2023

CRCMSS/pMMR contain a significantly increased fraction of TREM2+ macrophages (TAMs) and CD66+ neutrophils (TANs) together with decrease of CD4-CD8-CD3+ double negative T lymphocytes (DNTs); no differences were revealed by the analysis of myeloid and plasmacytoid dendritic cell populations. A fraction of tumor-infiltrating T-cells display an exhausted phenotype, co-expressing PD-1 and TIM-3. Remarkably, expression of PD-L1 on fresh tumor cells and TAMs was undetectable even after in vitro stimulation with interferon-γ. These findings confirm the immune suppressive microenvironment of CRCMSS/pMMR characterized by dense infiltration of TAMs, occurrence of TANs, lack of DNTs, T-cell exhaustion and interferon-γ unresponsiveness by host and tumor cells. Appropriate bypass strategies should consider these combinations of immune escape mechanisms in CRCMSS/pMMR.
Leukotrienes E4 and B4 and Vascular Endothelium – New Insight into the Link between Vascular Inflammation and Peripheral Arterial Disease and Its Complications
Authors: Wachsmann-Maga Agnieszka , Włodarczyk Aleksandra , Maga Mikołaj , Batko Krzysztof , Bogucka Katarzyna , Kapusta Maria , Terlecki Piotr , Maga Paweł
Published: May 2023

Leukotrienes are proinflammatory mediators that participate in the process of atherogenesis and contribute to the development of symptomatic peripheral arterial disease. The aim was to evaluate the relationship between leukotriene E4 (LTE4) and B4 (LTB4) with parameters reflecting endothelial vascular function in patients with chronic lower limb ischemia. This prospective observational study enrolled 50 consecutive patients undergoing endovascular treatment due to chronic lower limb ischemia (Rutherford 3). All participants were followed-up for one year (after 1, 3, 6 and 12 months), with a sequential assessment of urinary LTE4 and LTB4, as well as measures of endothelial and vascular function: Flow-Mediated Dilatation (FMD), Intima-Media Thickness (IMT), corrected Augmentation Index (AI75), Shear Rate (SR), Ankle-Brachial Index (ABI), Toe-Brachial Index (TBI). There was a significant relationship between LTE4 and measures of vascular function: FMD (R2 = 0.69, P<0.001), IMT (R2=0.12, P<0.01), AI75 (R2=0.43, P<0.001), SR (R2=0.48, P<0.001). Similar findings were noted for LTB4: FMD (R2=0.47, p<0.001), IMT (R2=0.23, P<0.001), AI75 (R2=0.61, P<0.001) and SR (R2=0.33, P<0.001). Alterations in parameters were significantly related: ΔLTE4 vs ΔFMD(R2=0.63, P<0.001), ΔSR (R2=0.42, P<0.001) and ΔLTB4 vs AI75(R2=0.40, P<0.001), SR(R2=0. 29, P<0.001). We conclude, that increasing concentrations of LTE4 and LTB4 are associated with impairment of vascular and endothelial function, which may lead to worse endovascular treatment clinical outcomes.
Micro-Ct Features of Lung Consolidation, Collagen Deposition and Inflammation in Experimental Rsv Infection Are Aggravated in the Absence of Nrf2
Authors: Ivanciuc Teodora , Patrikeev Igor , Qu Yue , Motamedi Massoud , Jones-Hall Yava , Casola Antonella , Garofalo Roberto P.
Published: May 2023

Severe respiratory syncytial virus (RSV) infections in early life have been linked to the development of chronic airway disease. RSV is a potent inducer of reactive oxygen species (ROS) which contributes to inflammation and enhanced clinical disease. NF-E2-related factor 2 (Nrf2) is an evolutionary conserved redox-responsive protein that helps to protect cells and whole organisms from oxidative stress and injury. The role of Nrf2 in the context of viral-mediated chronic lung injury is not known. Herein, we show that RSV experimental infection of adult Nrf2 deficient BALB/c mice (Nrf2-/-; Nrf2 KO) is characterized by enhanced disease, increased inflammatory cell recruitment to the bronchoalveolar compartment, and a more robust upregulation of innate and inflammatory genes and proteins, compared to wild type Nrf2+/+ competent mice (WT). These events that occur at very early time points, lead to increased peak RSV replication in Nrf2 KO compared to WT mice (day 5). To evaluate longitudinal changes of the lung architecture, mice were scanned weekly by high-resolution micro-computed tomography (micro-CT) imaging up to 28 days after initial viral inoculation. Based on micro-CT qualitative 2D imaging and quantitative reconstructed histogram-based analysis of lung volume and density, we found that RSV infected Nrf2 KO mice developed significantly greater and prolonged fibrosis compared to WT mice. Results of this study underscore the critical role of Nrf2-mediated protection from oxidative injury not only in acute pathogenesis of RSV infection, but also in its long-term consequences of chronic airway injury.
Tales Through a Cultural Lens: Exploring the Global Significance of Cinderella, Snow White, and Sleeping Beauty
Authors: Eslit Edgar R.
Published: May 2023

This article explores the cross-cultural significance of three iconic fairy tales: Cinderella, Snow White, and Sleeping Beauty. Using a comparative analysis approach, the study investigates recurring themes, motifs, and symbolism found in these tales across different cultures and time periods. The research draws on primary and secondary sources such as literary works and scholarly articles to uncover the underlying messages that resonate with audiences worldwide. The historical and cultural contexts of the tales are also examined to provide a deeper understanding of their significance in shaping cultural identity and values. The findings of the research demonstrate the enduring legacy of these tales and their continued relevance in contemporary society. The study highlights how the tales have evolved and adapted over time to reflect changing cultural values and beliefs. The interpretation of the findings offers insights into the role of storytelling in shaping cultural identity and values, and the ways in which these stories continue to inspire and captivate audiences worldwide. Overall, this research provides a comprehensive and nuanced understanding of the significance of these three fairy tales across cultures and time. By illuminating the similarities and differences in these tales, the study offers a fresh perspective on the power of storytelling and its ability to transcend cultural boundaries. The research contributes to the fields of folklore, cultural studies, and cross-cultural communication, inspiring further exploration into the captivating world of fairy tales.
Crystallographic Texture and Substructural Phenomena in 316 Stainless Steel Printed by Selective Laser Melting
Authors: Santamaria Ricardo , Salasi Mobin , Rickard William , Pojtanabuntoeng Kod , Leadbeater Garry , Iannuzzi Mariano , Reddy Steven , Quadir Md Zakaria
Published: May 2023

There is a fast-growing interest in the use of selective laser melting (SLM) for metal/alloy additive manufacturing. Our current knowledge of SLM printed 316 stainless steel (SS316) is limited and sometimes appears sporadic, presumably due to the complex interdependent effects of a large number of process variables of the SLM processing. This is reflected from the discrepant findings in the crystallographic textures and microstructures in this investigation with those reported in the literatures, which also vary itself. The as-printed material is macroscopically asymmetric in both the structures and crystallographic textures. The <101> and <111> crystallographic directions align parallel with the SLM scanning direction (SD) and build direction (BD), respectively. Like-wise, some characteristic low angle boundary features are reported crystallographic, while this investigation unequivocally proves them non-crystallographic since they always maintain an identical alignment with the SLM laser scanning direction irrespective of the matrix material’s crystal orientation. There is also 500±200 nm columnar or cellular features, depending on the cross-section, generally found all over the sample. These columnar or cellular features are formed with walls made of dense packing of dislocations entangled with Mn, Si and O enriched amorphous inclusions. They remain stable after the ASM solution treatments at 1050 °C temperatures, and therefore, are capable of hindering boundary migration events of recrystallization and grain growth. Thus, the nanoscale structures can be retained at high temperatures. Large 2-4 µm inclusions form during the solution treatment, within which the chemical and phase distribution are heterogeneous.
DFT Studies of the Adsorption of Propane and Propene on Metallic Surfaces in Ag/ZrO2 Catalysts as a Model for Catalytic Combustion Reactions of Light Hydrocarbons
Authors: Ruggera José F. , Ocsachoque Marco A. , Montaña Maia , Casella Mónica L. , Lick Ileana D.
Published: May 2023

Molecular modeling studies were carried out at the DFT level of the adsorption of propane and propene on Ag surfaces as a model of the interaction of light hydrocarbons with Ag/ZrO2 catalysts for the catalytic combustion reaction. It was found that the most stable mode of adsorption of propene through its π system on Ag atom has energies consistent with chemisorption and generates an elongation of the C1=C2 bond, which would explain the increase in the activity of the catalysts as function of its metallic charge. The results obtained from the DFT calculations explain the different types of interaction between propene and propane with the metallic surface. The propene is chemisorbed on the Ag surface, distorting its bonds and generating its activation. This would imply that a higher metallic charge in the catalyst would increase the number of active sites in which this activation occurs, generating a higher activity. Besides, with the addition of O, the binding energy between the propene and the metal surface increased. On the other hand, the presence of a metallic surface is not enough for the activation of the propane molecule. This would explain why by increasing the amount of metal in the catalyst, the activity for the combustion of propane is practically not affected
MODEL KESIAPSIAGAAN KELUARGA TERHADAP ANCAMAN BAHAYA BENCANA GEMPA BUMI DESA CONDONGCATUR, KAPANEWON DEPOK, KABUPATEN SLEMAN, D.I. YOGYAKARTA
Authors: Puspitasari Lisa , Prastistho Bambang , Prasetya Johan Danu
Published: May 2023

This study aims to find out the model of family preparedness, describe infrastructure facilities foe earthquake threat and assess factors that are the level of preparedness of the people of Condongcatur village against the threat of earthquake disasters. The study used quantitative methods, as well as sampling using purposive sampling techniques with family preparedness scale measurement tools, factors that affect family preparedness levels and observation sheets of facilities and infrastructure. The study subjects were people living in the village of Condongcatur and their analytical techniques using multiple regression analysis and using the help of the SPSS 23.00 for windowa computer program. The results of multiple regression analysis obtained knowledge variables about earthquakes with a calculated value 4,295, variable emergency response plan value tcalculate 2,416, variabel disaster warning system value tcalculated 3,065 and variable of resource mobility value tcalculated 7,280 with significance value 0,000 < 0,05 which means it can be concuded that preparedness in the village of Condongcatur against the threat of earthquakes in the category of ready and factores that affect preparedness in the village of Condongcatur against the threat of earthquake disaster in the category of very ready, as well as observation of facilities and infrastructure for the threat of earthquake disaster in the village of Condongcatur in the high category. Advice for researchers is expected to develop supporting factors that affect family preparedness in the village of Condongcatur against the threat of earthquake hazards.
Acculturation of Java and Chinese Culture in Historical Perspective
Authors: Alam M Bagus Sekar
Published: May 2023

The purpose of this study is to explain historically the acculturation process of Javanese-Chinese culture which its existence is still being felt today. The research question is how was the process of acculturation of Javanese and Chinese culture and what form. The method used in this study is the historical method which has four operational steps: Heuristics, criticism, interpretation,  and historiography. A search for library research is needed to find out initial information on the problems being studied. Anthropological and sociological approaches are needed to sharpen data analysis. The results of this study explain that the acculturation of Javanese and Chinese culture was formed through a long historical process since the 5th century AD. The initial interaction of ethnic Chinese with Javanese people took place intensively through trade relations. The arrival of ethnic Chinese to Java took place gradually by sea. The interaction of ethnic Chinese culture with the local community runs naturally and without any cultural conflict between the two. This long-standing cultural interaction has resulted in the acculturation of Javanese and Chinese cultures merging into one local culture of the Javanese people. Almost all elements of Javanese life are more or less influenced by Chinese culture. As in architecture, food, literature, batik, sports, musical instruments, religion, performing arts and traditions. The conclusion of this study shows that the process of acculturation of Javanese and Chinese cultures has given birth to a mixed culture that has become part of the cultural wealth of Javanese society.
Research on the Development of China-Indonesia Tourism Cooperation Under the Background of the Belt and Road--Based on the Perspective of Normalization of Public Health Emergency Management 一带一路背景下中印尼旅游合作发展研究——以公共卫生应急管理常态化为视角
Authors: Danping LIU , Hedan FANG , Miaoxuan WU , Hao WU
Published: May 2023

In 2022, China and Indonesia will enter the 72nd year of diplomatic relations, and since China's Belt and Road Initiative in 2013, the relationship between China and Indonesia in the fields of humanities, economy, trade and tourism has reached a new level. Tourism cooperation between the two countries is not only an important part of the initiative, but also an important way to meet the needs of tourism development in both countries, deepen trade and economic cooperation, and promote the construction of the Belt and Road. However, the development of tourism cooperation between the two countries has outstanding problems such as security issues, insufficient depth of cooperation and single approach, while the sudden outbreak of the epidemic at the end of 2019 has dealt a heavy blow to the tourism industry of the two countries and has affected the economy and trade of them. Based on the background of the Belt and Road, this article reorganizes the background, dynamics and obstacles of China-Indonesian tourism cooperation from the perspective of the normalization of public health emergency management, and builds a new path model to promote the deepening development of tourism cooperation between the two countries based on this, with a view to becoming an important path choice to promote the optimization and upgrading of bilateral tourism cooperation between China and Indonesia.
SOSIALISASI PEMBANGUNAN RENDAH KARBON MENGGUNAKAN PENDEKATAN PARTISIPATORY RURAL APPRAISAL (PRA) DI DESA CIKONDANG KECAMATAN HANTARA KABUPATEN KUNINGAN, JAWA BARAT
Authors: Nasihin Iing , Waniatri Wina
Published: May 2023

Perubahan iklim menjadi permasalahan dunia yang sangat serius saat ini. Bahaya yang ditimbulkan perubahan iklim telah membuat isu ini menjadi permasalahan utama baik di kancah nasional maupun internasional, tidak terkecuali Indonesia. Pembangunan Rendah Karbon/Low Carbon Development (PRK/LCD) adalah platform pengembangan baru untuk mempertahankan pertumbuhan ekonomi dan sosial melalui aktivitas dengan emisi Gas Rumah Kaca (GRK) dan intensitas emisi GRK yang rendah serta mengurangi penggunaan sumber daya alam. Jasa lingkungan berbasis desa dapat berkontribusi dalam penekanan emisi karbon. Metode yang digunakan untuk mengatasi permasalahan dilakukan dengan metode penyuluhan dengan presentasi yang dilakukan sosialisasi secara berkala antara pendamping dengan kelompok sasaran. Model pendekatan yang dilakukan yaitu Partisipatory Rural Appraisal (PRA). Program pengabdian masyarakat  yang dikemas dalam bentuk   penyuluhan ini bertujuan   untuk meningkatkan pengetahuan dan kesadaran masyarakat desa yang peduli lingkungan. Berdasarkan pelaksanaan evaluasi, penyuluhan ini telah berhasil meningkatkan pengetahuan (84,62%), wawasan (69,23%) dan  kesadaran (61,54%) masyarakat untuk dapat mewujudkan pembangunan desa rendah karbon.
Klasifikasi Tingkat Keparahan Penyakit Leafblast Tanaman Padi Menggunakan MobileNetv2
Authors: Annur Imam Fauzi , Umami Jumhurul , Annafii Moch. Nasheh , Trisnaningrum Niken , Putra Oddy Virgantara
Published: May 2023

AbstrakPadi merupakan tanaman pangan pokok di Indonesia, dan produksinya merupakan kunci ketahanan pangan negara. Keberhasilan panen merupakan faktor penting dalam pencegahan impor bahan pangan pokok. Tantangan terbesar dalam memanen tanaman adalah adanya virus, jamur, dan hama yang dapat merusak tanaman. Penelitian ini bertujuan untuk membuat sistem klasifikasi tingkat keparahan penyakit daun pada tanaman padi yang terkena penyakit blas daun dengan bantuan algoritma machine learning. MobileNetV2 adalah arsitektur Convolutional Neural Network (CNN) yang menggunakan Depthwise Separable Convolution untuk membangun model yang ringan dan dirancang untuk mengatasi proses yang memiliki resource yang berlebih. Dataset yang digunakan pada penelitian ini merupakan hasil murni observasi peneliti yang sudah divalidasi oleh ahli dengan total 300 data asli. Model MobileNetV2 ternyata sangat berhasil dalam mengklasifikasikan objek, dengan akurasi 78,33%. dengan hasil penelitian ini, petani dapat terbantu dalam mengenali tingkat keparahan penyakit leafblast pada tanaman padi sehingga pemberian bahan kimia berupa fungisida sesuai dengan dosis anjuran tingkat keparahan. Kata kunci: Klasifikasi, leafblast, padi, citra, model pre-trained, MobileNetV2. Abstract[Classification Of Rice Blast Disease Using MobileNetV2] Rice is a staple food crop in Indonesia, and its production is key to the country's food security. Successful harvesting is an important factor in preventing imports of staple foods. The biggest challenge in harvesting crops is the presence of viruses, fungi, and pests that can damage plants. This research aims to create a classification system for leaf disease severity in rice plants affected by leaf blast disease with the help of machine learning algorithms. MobileNetV2 is a Convolutional Neural Network (CNN) architecture that uses Depthwise Separable Convolution to build lightweight models and is designed to overcome processes that have excessive resources. The dataset used in this study is the result of pure researcher observations that have been validated by experts with a total of 300 original data. The MobileNetV2 model turned out to be very successful in classifying objects, with an accuracy of 78.33%. with the results of this study, farmers can be helped in recognizing the severity of leafblast disease in rice plants so that the provision of chemicals in the form of fungicides in accordance with the recommended dose of severity.Keywords: Classification, leafblast, rice, image, pre-trained model, MobileNetV2
Inovação em Políticas Públicas de Saúde: Desafios e possibilidades na efetivação da Política Nacional de Transplante de Órgãos e Tecidos no Estado do Amazonas
Authors: Alves da Silva Maria Altina , TAVARES PEREIRA Maurício , Silva Márcia Maria Moraes
Published: May 2023

O presente trabalho tem como objetivo principal identificar os desafios e possibilidades para a efetivação da Política Nacional de Transplante de Órgãos e Tecidos, PNT, no Estado do Amazonas, região com características sui generis que a convertem em lócus especial de análise, dado o gigantismo do território estadual e as distâncias de milhares de km entre os seus municípios, além da inexistência de transporte rodoviário devido à geografia amazônica. O estudo tem caráter dialético, descritivo e propositivo, sendo sua abordagem quali-quantitativa, com base em pesquisa documental sobre dados secundários, destacando a experiência do Transplante de Fígado no Amazonas. Para atingir o objetivo proposto, optou-se por realizar uma pesquisa bibliográfica em bases de dados digitais, especialmente a plataforma Scholar Google®, buscando-se artigos, livros, e revistas que tratam do assunto em pauta, além dos informativos do Ministério da Saúde, MS, Secretaria de Saúde do Estado do Amazonas, SUSAM. Descreveu-se então de maneira simplificada a trajetória do desenvolvimento dos transplantes no Brasil, contextualizando-se o transplante no cenário das Políticas Públicas de Saúde e por fim, identificando-se os desafios e possibilidade na efetivação da PNT no Estado do Amazonas. Dentre os resultados, destaca-se primeiramente que o Brasil possui na atualidade um dos maiores programas públicos de transplantes de órgãos e tecidos do mundo, e também no caso do Amazonas que, apesar dos avanços obtidos, ainda não se consegue atender de forma efetiva a demanda por transplantes de fígado neste Estado, com crescentes filas de espera.