bluuebunny/crossref_metadata_2025 huggingface dataset:
Beneficial role of deferasirox and deferiprone in the mobilization of arsenic and recovery of iron in rat tissues
Authors: Amiri Asghar , Mirhoseiny Zahra
Published: February 2017

The aim of this research was to test the chelation potency of deferasirox (DFS or ICL670)) and deferiprone (L1) in mobilization of arsenic in arsenic-exposed rats. Male Wistar rats were exposed to 60 mg/kg body weight sodium arsenite in drinking water for six weeks, followed by treatment with DFS (80 mg/kg body weight, oral, once daily), L1(100 mg/kg body weight, oral, once daily) alone or in combination, for six consecutive days. After chelation therapy, these rats were anesthetized by ether vapor, were immobilized by cervical dislocation and then their heart, liver, kidneys, intestine and blood were sampled for clinical hematological variables and determination of arsenic and iron concentration by Inductively Coupled Plasma/Optical Emission Spectrometry (ICP-OES). Comparison of single and combined therapy showed that the combined chelation therapy (DFS+L1) is more effective in depleting arsenic concentration from soft tissues. No effects of arsenic or any of the two treatments (L1 or DFS) on WBC, RBC and Hb were observed. Interestingly, platelet counts showed a decrease in arsenic exposure. The obtained Results of combined treatment should be confirmed by a different experimental model before extrapolation to other systems.
Quantitative estimations of the abundant constituents of alotropis procera
Authors: Morsy Nagy
Published: February 2017

From previous studies, Calotropis procera showed the presence of cardiac glycosides, sterols, hydrocarbons, fatty acids, flavonoids. The abundant constituents are cardiac glycosides and lipids including sterols, hydrocarbons and fatty acids that encourage the author in this work to study them quantitatively. The distinct odour of the plant paid the attention for studying the essential oils of the plant organs. In addition, cardiac glycosides were estimated, after a rapid purification method, with two reagents for comparison and to judge the reliability. The methods can be used for industrial purposes.
Technicities of Deception: Dazzle Camouflage, Avant-Gardes and Sensory Augmentation in the First World War
Authors: White Eric
Published: February 2017

This essay identifies a new form of technicity that emerged in the First World War, in which enhancement and distortion effects generated by sensory augmentation technologies could be manipulated for strategic purposes by a variety of cultural agents. It argues that dazzle camouflage, a technology developed by the British Admiralty in 1917 to delay and confuse attacking U-boats, exemplifies this mediation of everyday life both on and off the battle fronts. Focusing on the London Vorticists, but also drawing on Futurist precedents, the essay explores how avant-gardes articulated the impact that technicities of augmentation had on modern selfhood.
Lyotard's Differend: Radical and Unresolved Dispute, from the Political to the Literary
Authors: Tomiche Anne
Published: February 2017

Lyotard's notion of the differend can be analysed as a philosophical theory of radical disputes, that is, disputes with no possible resolution other than the silencing of one of the parties. The concept is explicitly meant to shed light on ethical, historical and political debates, while literature and psychoanalysis are strikingly absent from this theory. However, the concept of the differend is crucial to Lyotard's own discussions of literature and art. Developing from a reading of some of his texts on literature and art and on psychoanalysis, this essay shows how the concept of the differend operates in Lyotard's understanding and appreciation of literature and art, in order to then ask how the differend can help us think issues of ‘modernity’, ‘modernism’ and ‘postmodernism’ in terms other than those of literary history, and can help us think experimental writings and artistic practices of the twentieth century in terms other than those of provocation or scandal.
Microwave-Assisted Synthesis of SiC Nanoparticles for the Efficient Adsorptive Removal of Nitroimidazole Antibiotics from Aqueous Solution
Authors: Fakhri Ali , Rashidi Sahar , Asif Mohammad , Ibrahim Ahmed
Published: February 2017

Environmental pollution caused by the improper disposal of pharmaceuticals is a matter of global concern, and warrants immediate attention. Of particular concern is the aquatic contamination caused by the increasing use of antibiotics, which could give rise to superbugs. While researchers have mainly focused on improving the adsorption capacity of mostly activated carbon-based adsorbents, we have developed a non-conventional adsorbent (SiC nanoparticles) in the present work for the adsorptive removal of four different nitroimidazole antibiotics, namely metronidazole (MNZ), dimetridazole (DMZ), ronidazole (RNZ), and tinidazole (TNZ). In addition to the unique properties which are inherent to SiC, the present adsorbent not only possesses a high adsorption capacity, but also shows one of the highest adsorption rates; both of which are prerequisites for an efficient and cost-effective adsorption-based separation technology. Silicon carbide (SiC) nanoparticles, synthesized by a microwave-assisted method, were thoroughly characterized using X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and the Brunauer–Emmett–Teller method. The adsorption isotherm data were accurately described by the Langmuir isotherm model. On the other hand, the adsorption kinetics, closely represented by the pseudo-second order kinetic model, were faster than most previously reported adsorbents. The reaction rate constants were 0.0089, 0.0079, 0.0072, and 0.0055 g/(mg min), for MNZ, DMZ, RNZ, and TNZ, respectively.
Climatic Variability and Land Use Change in Kamala Watershed, Sindhuli District, Nepal
Authors: Neupane Muna , Dhakal Subodh
Published: February 2017

This study focuses on the land use change and climatic variability assessment around Kamala watershed, Sindhuli district, Nepal. The study area covers two municipalities and eight Village Development Committees (VDCs). In this paper, land use change and the climatic variability are examined. The study was focused on analyzing the changes in land use area within the period of 1995 to 2014 and how the climatic data have evolved in different meteorological stations around the watershed. The topographic maps, Google Earth images and ArcGIS 10.1 for four successive years, 1995, 2005, 2010, and 2014 were used to prepare the land use map. The trend analysis of temperature and precipitation data was conducted using Mann Kendall trend analysis and Sen’s slope method using R (3.1.2 version) software. It was found that from 1995 to 2014, the forest area, river terrace, pond, and landslide area decreased while the cropland, settlement, and orchard area increased. The temperature and precipitation trend analysis shows variability in annual, maximum, and seasonal rainfall at different stations. The maximum and minimum temperature increased in all the respective stations, but the changes are statistically insignificant. The Sen’s slope for annual rainfall at ten different stations varied between −38.9 to 4.8 mm per year. Land use change and climatic variability have been analyzed; however, further study is required to establish any relation between climatic variability and land use change.
Urban Land Use Land Cover Changes and Their Effect on Land Surface Temperature: Case Study Using Dohuk City in the Kurdistan Region of Iraq
Authors: Faqe Ibrahim Gaylan
Published: February 2017

The growth of urban areas has a significant impact on land use by replacing areas of vegetation with residential and commercial areas and their related infrastructure; this escalates the land surface temperature (LST). Rapid urban growth has occurred in Duhok City due to enhanced political and economic growth during the period of this study. The objective is to investigate the effect of land use changes on LST; this study depends on data from three Landsat images (two Landsat 5-TM and Landsat OLI_TIRS-8) from 1990, 2000 and 2016. Supervised classification was used to compute land use/cover categories, and to generate the land surface temperature (LST) maps the Mono-window algorithm was used. Images were also used to create the normalized difference vegetation index (NDVI), normalized difference built-up index (NDBI), normalized difference bareness index (NDBAI) and normalized difference water index (NDWI) maps. Linear regression analysis was used to generate relationships between LST with NDVI, NDBI, NDBAI and NDWI. The study outcome proves that the changes in land use/cover have a significant role in the escalation of land surface temperatures. The highest temperatures are associated with barren land and built-up areas, ranging from 47°C, 50°C, 56°C while lower temperatures are related to water bodies and forests, ranging from 25°C, 26°C, 29°C respectively, in 1990, 2000 and 2016. This study also proves that NDVI and NDWI correlate negatively with low temperatures while NDBI and NDBAI correlate positively with high temperatures.
Static and Dynamic Magnetization Investigation in Permalloy Electrodeposited onto High Resistive N-Type Silicon Substrates
Authors: Freitas Kenedy , Toledo José , Figueiredo Leandro , Morais Paulo , Felix Jorlandio , De Araujo Clodoaldo
Published: February 2017

The present study reports on the development of permalloy thin films obtained by electrodeposition onto low-doped n-type silicon substrates. While changing from non-percolated clusters into percolated thin films upon increasing the electrodeposition time, the static and dynamic magnetic properties of the as-obtained structures were investigated. We found the experimental magnetic results to be in very good agreement with the simulations performed by solving the Landau-Lifshitz for the dynamics of the magnetic moment. For short electrodeposition times we found the static and dynamic magnetization behavior of the as-formed nanoclusters evidencing vortex magnetization with random chirality and polarization, which is explained in terms of dipolar interaction minimization. Indeed, it is herein emphasized that recent applications of ferromagnetic materials in silicon-based spintronic devices, such as logic and bipolar magnetic transistors and magnetic memories, have revived the possible utilization of low cost and simple electrodeposition techniques for the development of these upcoming hetero-nanostructured devices.
Silver Nanoprism-Loaded Eggshell Membrane: A Facile Platform for In Situ SERS Monitoring of Catalytic Reactions
Authors: Li Yaling , Ye Yong , Fan Yunde , Zhou Ji , Jia Li , Tang Bin , Wang Xungai
Published: February 2017

We reported the fabrication of an in situ surface-enhanced Raman scattering (SERS) monitoring platform, comprised of a porous eggshell membrane (ESM) bioscaffold loaded with Ag nanoprism via an electrostatic self-assembly approach. The localized surface plasmon resonance (LSPR) property of silver nanoprism leads to the blue color of the treated ESMs. UV-vis diffuse reflectance spectroscopy, scanning electron microscope (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) measurements were employed to observe the microstructure and surface property of Ag nanoprisms on the ESMs. The silver nanoprism-loaded eggshell membrane (AgNP@ESM) exhibited strong catalytic activity for the reduction of 4-nitrophenol by sodium borohydride (NaBH4) and it can be easily recovered and reused for more than six cycles. Significantly, the composites also display excellent SERS efficiency, allowing the in situ SERS monitoring of molecular transformation in heterogeneous catalysis. The results indicate that the AgNP@ESM biocomposite can achieve both SERS and catalytic functionalities simultaneously in a single entity with high performance, which promotes the potential applications of ESM modified with functional materials.
Environmental Assessment of Possible Future Waste Management Scenarios
Authors: Arushanyan Yevgeniya , Björklund Anna , Eriksson Ola , Finnveden Göran , Ljunggren Söderman Maria , Sundqvist Jan-Olov , Stenmarck Åsa
Published: February 2017

Waste management has developed in many countries and will continue to do so. Changes towards increased recovery of resources in order to meet climate targets and for society to transition to a circular economy are important driving forces. Scenarios are important tools for planning and assessing possible future developments and policies. This paper presents a comprehensive life cycle assessment (LCA) model for environmental assessments of scenarios and waste management policy instruments. It is unique by including almost all waste flows in a country and also allow for including waste prevention. The results show that the environmental impacts from future waste management scenarios in Sweden can differ a lot. Waste management will continue to contribute with environmental benefits, but less so in the more sustainable future scenarios, since the surrounding energy and transportation systems will be less polluting and also because less waste will be produced. Valuation results indicate that climate change, human toxicity and resource depletion are the most important environmental impact categories for the Swedish waste management system. Emissions of fossil CO2 from waste incineration will continue to be a major source of environmental impacts in these scenarios. The model is used for analyzing environmental impacts of several policy instruments including weight based collection fee, incineration tax, a resource tax and inclusion of waste in a green electricity certification system. The effect of the studied policy instruments in isolation are in most cases limited, suggesting that stronger policy instruments as well as combinations are necessary to reach policy goals as set out in for example the EU action plan on circular economy.
A New Model for Estimating the Diffuse Fraction of Solar Irradiance for Photovoltaic System Simulations
Authors: Hofmann Martin , Seckmeyer Gunther
Published: February 2017

We present a new model for the calculation of the diffuse fraction of the global solar irradiance for solar system simulations. The importance of an accurate estimation of the horizontal diffuse irradiance is highlighted by findings that an inaccurately calculated diffuse irradiance can lead to significant over- or underestimations in the annual energy yield of a photovoltaic (PV) system by as much as 8%. Our model utilizes a time series of global irradiance in one-minute resolution and geographical information as input. The model is validated by measurement data of 28 geographically and climatologically diverse locations worldwide with one year of one-minute data each, taken from the Baseline Surface Radiation Network (BSRN). We show that on average the mean absolute deviation of the modelled and the measured diffuse irradiance is reduced from about 12% to about 6% compared to three reference models. The maximum deviation is less than 20%. In more than 80% of the test cases, the deviation is smaller 10%. The root mean squared error (RMSE) of the calculated diffuse fractions is reduced by about 18%.
Production Characteristics with Different Superimposed Modes Using Variogram: A Case Study of a Super-Giant Carbonate Reservoir in the Middle East
Authors: Wei Chenji , Song Hongqing , Li Yong , Zhang Qi , Song Benbiao , Wang Jiulong
Published: February 2017

Heterogeneity of permeability is an important factor affecting the production of a carbonate reservoir. How to correctly characterize the heterogeneity of permeability has become a key issue for carbonate reservoir development. In this study, the reservoirs were categorized into four superimposed modes based on the actual logging data from a super-giant heterogeneous carbonate reservoir in the Middle East. A modified permeability formula in terms of the variogram method was presented to reflect the heterogeneity of the reservoirs. Furthermore, the models of oil production and water cut were established and the analytical solutions were obtained. The calculation results show that the present model can predict the productivity of wells with different heterogeneous layers more accurately and rapidly. The larger the varigoram value, the stronger the heterogeneity of the reservoirs, and the faster the decline of production owing to a quicker reduction of formation pressure. With the increase in variogram value, the relative permeability of the oil phase is smaller and the water phase larger, and the water cut becomes larger. This study has provided a quick and reasonable prediction model for heterogeneous reservoir.
Spatial and Temporal Wind Power Forecasting by Case-Based Reasoning Using Big-Data
Authors: De Caro Fabrizio , Vaccaro Alfredo , Villacci Domenico
Published: February 2017

The massive penetration of wind generators in electrical power systems asks for effective wind power forecasting tools, which should be high reliable, in order to mitigate the effects of the uncertain generation profiles, and fast enough to enhance power system operation. To address these two conflicting objectives, this paper advocates the role of knowledge discovery from big-data, by proposing the integration of adaptive Case Based Reasoning models, and cardinality reduction techniques based on Partial Least Squares Regression, and Principal Component Analysis. The main idea is to learn from a large database of historical climatic observations, how to solve the windforecasting problem, avoiding complex and time-consuming computations. To assess the benefits derived by the application of the proposed methodology in complex application scenarios, the experimental results obtained in a real case study will be presented and discussed.
A New Vertical JFET Power Device for Harsh Radiation Environments
Authors: Fernández-Martínez Pablo , Flores David , Hidalgo Salvador , Jordà Xavier , Perpiñà Xavier , Quirion David , Ré Lucia , Ullán Miguel , Vellvehí Miquel
Published: February 2017

An increasing demand for power electronic devices able to be operative in harsh radiation environments is now taking place. Specifically, in High Energy Physics experiments the required power devices are expected to withstand very high radiation levels which are normally too hard for most of the available commercial solutions. In this context, a new vertical junction field effect transistor (JFET) has been designed and fabricated at the Instituto de Microelectrónica de Barcelona, Centro Nacional de Microelectrónica (IMB-CNM, CSIC). The new silicon V-JFET devices draw upon a deep-trenched technology to achieve volume conduction and low switch-off voltage, together with a moderately high voltage capability. The first batches of V-JFET prototypes have been already fabricated at the IMB-CNM clean room, and several aspects of their design, fabrication and the outcome of their characterization are summarized and discussed in this paper. Radiation hardness of the fabricated transistors have been tested both with gamma and neutron irradiations, and the results are also included in the contribution.
Small Scale Problems of the ΛCDM Model: A Short Review
Authors: Del Popolo Antonino , Le Delliou Morgan
Published: February 2017

The ΛCDM model, or concordance cosmology, as it is often called, is a paradigm at its maturity. It is clearly able to describe the universe at large scale, even if some issues remain open, such as the cosmological constant problem, the small-scale problems in galaxy formation, or the unexplained anomalies in the CMB. ΛCDM clearly shows difficulty at small scales, which could be related to our scant understanding, from the nature of dark matter to that of gravity; or to the role of baryon physics, which is not well understood and implemented in simulation codes or in semi-analytic models. At this stage, it is of fundamental importance to understand whether the problems encountered by the ΛDCM model are a sign of its limits or a sign of our failures in getting the finer details right. In the present paper, we will review the small-scale problems of the ΛCDM model, and we will discuss the proposed solutions and to what extent they are able to give us a theory accurately describing the phenomena in the complete range of scale of the observed universe.
Deep Transcriptome Sequencing of Two Green Algae, Chara vulgaris and Chlamydomonas reinhardtii, Provides No Evidence of Organellar RNA Editing
Authors: Cahoon A. , Nauss John , Stanley Conner , Qureshi Ali
Published: February 2017

Nearly all land plants post‐transcriptionally modify specific nucleotides within RNAs, a process known as RNA editing. This adaptation allows the correction of deleterious mutations within the asexually reproducing and presumably non‐recombinant chloroplast and mitochondrial genomes. There are no reports of RNA editing in any of the green algae so this phenomenon is presumed to have originated in embryophytes either after the invasion of land or in the now extinct algal ancestor of all land plants. This was challenged when a recent in silico screen for RNA edit sites based on genomic sequence homology predicted edit sites in the green alga Chara vulgaris, a multicellular alga found within the Streptophyta clade and one of the closest extant algal relatives of land plants. In this study, the organelle transcriptomes of C. vulgaris and Chlamydomonas reinhardtii were deep sequenced for a comprehensive assessment of RNA editing. Initial analyses based solely on sequence comparisons suggested potential edit sites in both species, but subsequent high‐resolution melt analysis, RNase H‐dependent PCR (rhPCR), and Sanger sequencing of DNA and complementary DNAs (cDNAs) from each of the putative edit sites revealed them to be either single‐nucleotide polymorphisms (SNPs) or spurious deep sequencing results. The lack of RNA editing in these two lineages is consistent with the current hypothesis that RNA editing evolved after embryophytes split from its ancestral algal lineage.
Targeting MDM4 Splicing in Cancers
Authors: Bardot Boris , Toledo Franck
Published: February 2017

MDM4, an essential negative regulator of the P53 tumor suppressor, is frequently overexpressed in cancer cells that harbor a wild‐type P53. By a mechanism based on alternative splicing, the MDM4 gene generates two mutually exclusive isoforms: MDM4-FL, which encodes the full‐length MDM4 protein, and a shorter splice variant called MDM4-S. Previous results suggested that the MDM4-S isoform could be an important driver of tumor development. In this short review, we discuss a recent set of data indicating that MDM4-S is more likely a passenger isoform during tumorigenesis and that targeting MDM4 splicing to prevent MDM4-FL protein expression appears as a promising strategy to reactivate p53 in cancer cells. The benefits and risks associated with this strategy are also discussed.
Impact of Particulate Matter Exposure and Surrounding “Greenness” on Chronic Absenteeism in Massachusetts Public Schools
Authors: MacNaughton Piers , Eitland Erika , Kloog Itai , Schwartz Joel , Allen Joseph
Published: February 2017

Chronic absenteeism is associated with poorer academic performance and higher attrition in kindergarten to 12th grade (K-12) schools. In prior research, students who were chronically absent generally had fewer employment opportunities and worse health after graduation. We examined the impact that environmental factors surrounding schools have on chronic absenteeism. We estimated the greenness (Normalized Difference Vegetation Index (NDVI)) and fine particulate matter air pollution (PM2.5) within 250 m and 1000 m respectively of each public school in Massachusetts during the 2012–2013 academic year using satellite-based data. We modeled chronic absenteeism rates in the same year as a function of PM2.5 and NDVI, controlling for race and household income. Among the 1772 public schools in Massachusetts, a 0.15 increase in NDVI during the academic year was associated with a 2.6% (p value < 0.0001) reduction in chronic absenteeism rates, and a 1 μg/m3 increase in PM2.5 during the academic year was associated with a 1.58% (p value < 0.0001) increase in chronic absenteeism rates. Based on these percentage changes in chronic absenteeism, a 0.15 increase in NDVI and 1 μg/m3 increase in PM2.5 correspond to 25,837 fewer students and 15,852 more students chronically absent each year in Massachusetts respectively. These environmental impacts on absenteeism reinforce the need to protect green spaces and reduce air pollution around schools.
Biomarkers in Pediatric Community-Acquired Pneumonia
Authors: Principi Nicola , Esposito Susanna
Published: February 2017

Community-acquired pneumonia (CAP) is an infectious disease caused by bacteria, viruses, or a combination of these infectious agents. The severity of the clinical manifestations of CAP varies significantly. Consequently, both the differentiation of viral from bacterial CAP cases and the accurate assessment and prediction of disease severity are critical for effectively managing individuals with CAP. To solve questionable cases, several biomarkers indicating the etiology and severity of CAP have been studied. Unfortunately, only a few studies have examined the roles of these biomarkers in pediatric practice. The main aim of this paper is to detail current knowledge regarding the use of biomarkers to diagnose and treat CAP in children, analyzing the most recently published relevant studies. Despite several attempts, the etiologic diagnosis of pediatric CAP and the estimation of the potential outcome remain unsolved problems in most cases. Among traditional biomarkers, procalcitonin (PCT) appears to be the most effective for both selecting bacterial cases and evaluating the severity. However, a precise cut-off separating bacterial from viral and mild from severe cases has not been defined. The three-host protein assay based on C-reactive protein (CRP), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), plasma interferon-γ protein-10 (IP-10), and micro-array-based whole genome expression arrays might offer more advantages in comparison with former biomarkers. However, further studies are needed before the routine use of those presently in development can be recommended.
Waves as the Symmetry Principle Underlying Cosmic, Cell, and Human Languages
Authors: Ji Sungchul
Published: February 2017

In 1997, the author concluded that living cells use a molecular language (cellese) that is isomorphic with the human language (humanese) based on his finding that the former shared 10 out of the 13 design features of the latter. In 2012, the author postulated that cellese and humanese derived from a third language called the cosmic language (or cosmese) and that what was common among these three kinds of languages was waves—i.e., sound waves for humanese, concentration waves for cellese, and quantum waves for cosmese. These waves were suggested to be the symmetry principle underlying cosmese, cellese, and humanese. We can recognize at least five varieties of waves—(i) electromagnetic; (ii) mechanical; (iii) chemical concentration; (iv) gravitational; and (v) probability waves, the last being non-material, in contrast to the first four, which are all material. The study of waves is called “cymatics” and the invention of CymaScope by J. S. Reid of the United Kingdom in 2002 is expected to accelerate the study of waves in general. CymaScope has been used to visualize not only human sounds (i.e., humanese) but also sounds made by individual cells (cellese) in conjunction with Atomic Force Microscopy (AFM) (unpublished observations of J. Gimzewski of UCLA and J. Reid). It can be predicted that the gravitational waves recently detected by the Interferometer Gravitational-Wave Observatory (LIGO) will be visualized with CymaScope one day, thereby transforming gravitational waves into CymaGlyphs. Since cellese in part depends on RNA concentration waves (or RNA glyphs) and humanese includes hieroglyphs that were decoded by Champollion in 1822, it seems reasonable to use cymaglyphs, RNA glyphs, and hieroglyphs as symbols of cosmese, cellese, and humanese, respectively, all based on the principle of waves as the medium of communication.
CVD and Oxidative Stress
Authors: Cervantes Gracia Karla , Llanas-Cornejo Daniel , Husi Holger
Published: February 2017

Nowadays, it is known that oxidative stress plays at least two roles within the cell, the generation of cellular damage and the involvement in several signaling pathways in its balanced normal state. So far, a substantial amount of time and effort has been expended in the search for a clear link between cardiovascular disease (CVD) and the effects of oxidative stress. Here, we present an overview of the different sources and types of reactive oxygen species in CVD, highlight the relationship between CVD and oxidative stress and discuss the most prominent molecules that play an important role in CVD pathophysiology. Details are given regarding common pharmacological treatments used for cardiovascular distress and how some of them are acting upon ROS-related pathways and molecules. Novel therapies, recently proposed ROS biomarkers, as well as future challenges in the field are addressed. It is apparent that the search for a better understanding of how ROS are contributing to the pathophysiology of CVD is far from over, and new approaches and more suitable biomarkers are needed for the latter to be accomplished.
Application and Mechanism of Anionic Collector Sodium Dodecyl Sulfate (SDS) in Phosphate Beneficiation
Authors: Sun Kun , Liu Tao , Zhang Yimin , Liu Xin , Wang Bo , Xu Chengbao
Published: February 2017

Phosphate ore is a valuable strategic resource. Most phosphate ore in China is collophane. Utilization of mid-low grade collophane is necessary to maintain social sustainable development. The gravity-flotation combination separation process can be utilized to separate mid-low grade collophane, but the process consumes a large quantity of acid in the reverse stage. Sodium dodecyl sulfate (SDS) was used as a dolomite collector in this study to reduce the acid consumption of collophane flotation. SDS effectively removed dolomite from the gravity concentrate when no other reagents were present. Flotation test results showed that, compared to the conventional gravity-flotation process, the proposed SDS-based process reduced phosphoric acid dosage from 6.1 kg/t to 3.9 kg/t with similar separation results. The SDS action mechanisms on dolomite were further investigated by zeta potential analysis, single mineral flotation tests, infrared spectrum detection, and theoretical analysis. The results indicate that the SDS adsorption on dolomite is mainly physical adsorption, and that favorable separation effects between collophane and dolomite may be attributed to physical adsorption and entrainment. In addition, it also indicates that the physical adsorption can be utilized to remove dolomite from phosphate on account of zeta potential differences when the separate feed is coarse.
Three Chalconoids and a Pterocarpene from the Roots of Tephrosia aequilata
Authors: Atilaw Yoseph , Duffy Sandra , Heydenreich Matthias , Muiva-Mutisya Lois , Avery Vicky , Erdélyi Máté , Yenesew Abiy
Published: February 2017

In our search for new antiplasmodial agents, the CH2Cl2/CH3OH (1:1) extract of the roots of Tephrosia aequilata was investigated, and observed to cause 100% mortality of the chloroquine-sensitive (3D7) strain of Plasmodium falciparum at a 10 mg/mL concentration. From this extract three new chalconoids, E-2′,6′-dimethoxy-3′,4′-(2′′,2′′-dimethyl)pyranoretrochalcone (1, aequichalcone A), Z-2′,6′-dimethoxy-3′,4′-(2′′,2′′-dimethyl)pyranoretrochalcone (2, aequichalcone B), 4′′-ethoxy-3′′-hydroxypraecansone B (3, aequichalcone C) and a new pterocarpene, 3,4:8,9-dimethylenedioxy-6a,11a-pterocarpene (4), along with seven known compounds were isolated. The purified compounds were characterized by NMR spectroscopic and mass spectrometric analyses. Compound 1 slowly converts into 2 in solution, and thus the latter may have been enriched, or formed, during the extraction and separation process. The isomeric compounds 1 and 2 were both observed in the crude extract. Some of the isolated constituents showed good to moderate antiplasmodial activity against the chloroquine-sensitive (3D7) strain of Plasmodium falciparum.
Analysis of the Total Biflavonoids Extract from Selaginella doederleinii by HPLC-QTOF-MS and Its In Vitro and In Vivo Anticancer Effects
Authors: Yao Hong , Chen Bing , Zhang Yanyan , Ou Huigen , Li Yuxiang , Li Shaoguang , Shi Peiying , Lin Xinhua
Published: February 2017

Selaginella doederleinii Hieron has been traditionally used as a folk antitumor herbal medicine in China. In this paper, the phytochemical components of the total biflavonoids extract from S. doederleinii were studied by using high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (HPLC-ESI-QTOF MS/MS) in negative ion mode, and their in vitro and in vivo anticancer effects were evaluated. Four types of biflavonoids from S. doederleinii, including IC3′–IIC8′′, IC3′–IIC6′′, IC3′–IIC3′′′, and C–O linked biflavonoids were examined originally using QTOF MS/MS. The fragmentation behavior of IC3′–IIC3′′′ linked biflavonoids was reported for the first time. A total of twenty biflavonoids were identified or tentatively characterized and eight biflavonoids were found from S. doederleinii for the first time. Furthermore, the 3-(4,5-Dimethyl-2-thizolyl)-2,5-diphenyltertazolium bromide (MTT) assay and xenograft model of mouse lewis lung cancer(LLC) in male C57BL/6 mice revealed favorable anticancer properties of the total biflavonoids extracts from S. doederleinii. The results of this work could provide useful knowledge for the identification of biflavonoids in herbal samples and further insights into the chemopreventive function of this plant.
Green Hydroselenation of Aryl Alkynes: Divinyl Selenides as a Precursor of Resveratrol
Authors: Perin Gelson , Barcellos Angelita , Luz Eduardo , Borges Elton , Jacob Raquel , Lenardão Eder , Sancineto Luca , Santi Claudio
Published: February 2017

A simple and efficient protocol to prepare divinyl selenides has been developed by the regio- and stereoselective addition of sodium selenide species to aryl alkynes. The nucleophilic species was generates in situ, from the reaction of elemental selenium with NaBH4, utilizing PEG-400 as the solvent. Several divinyl selenides were obtained in moderate to excellent yields with selectivity for the (Z,Z)-isomer by a one-step procedure that was carried out at 60 °C in short reaction times. The methodology was extended to tellurium, giving the desired divinyl tellurides in good yields. Furthermore, the Fe-catalyzed cross-coupling reaction of bis(3,5-dimethoxystyryl) selenide 3f with (4-methoxyphenyl)magnesium bromide 5 afforded resveratrol trimethyl ether 6 in 57% yield.
Relationship between Long Chain n-3 Polyunsaturated Fatty Acids and Autism Spectrum Disorder: Systematic Review and Meta-Analysis of Case-Control and Randomised Controlled Trials
Authors: Mazahery Hajar , Stonehouse Welma , Delshad Maryam , Kruger Marlena , Conlon Cathryn , Beck Kathryn , Von Hurst Pamela
Published: February 2017

Omega-3 long chain polyunsaturated fatty acid supplementation (n-3 LCPUFA) for treatment of Autism Spectrum Disorder (ASD) is popular. The results of previous systematic reviews and meta-analyses of n-3 LCPUFA supplementation on ASD outcomes were inconclusive. Two meta-analyses were conducted; meta-analysis 1 compared blood levels of LCPUFA and their ratios arachidonic acid (ARA) to docosahexaenoic acid (DHA), ARA to eicosapentaenoic acid (EPA), or total n-6 to total n-3 LCPUFA in ASD to those of typically developing individuals (with no neurodevelopmental disorders), and meta-analysis 2 compared the effects of n-3 LCPUFA supplementation to placebo on symptoms of ASD. Case-control studies and randomised controlled trials (RCTs) were identified searching electronic databases up to May, 2016. Mean differences were pooled and analysed using inverse variance models. Heterogeneity was assessed using I2 statistic. Fifteen case-control studies (n = 1193) were reviewed. Compared with typically developed, ASD populations had lower DHA (−2.14 [95% CI −3.22 to −1.07]; p < 0.0001; I2 = 97%), EPA (−0.72 [95% CI −1.25 to −0.18]; p = 0.008; I2 = 88%), and ARA (−0.83 [95% CI, −1.48 to −0.17]; p = 0.01; I2 = 96%) and higher total n-6 LCPUFA to n-3 LCPUFA ratio (0.42 [95% CI 0.06 to 0.78]; p = 0.02; I2 = 74%). Four RCTs were included in meta-analysis 2 (n = 107). Compared with placebo, n-3 LCPUFA improved social interaction (−1.96 [95% CI −3.5 to −0.34]; p = 0.02; I2 = 0) and repetitive and restricted interests and behaviours (−1.08 [95% CI −2.17 to −0.01]; p = 0.05; I2 = 0). Populations with ASD have lower n-3 LCPUFA status and n-3 LCPUFA supplementation can potentially improve some ASD symptoms. Further research with large sample size and adequate study duration is warranted to confirm the efficacy of n-3 LCPUFA.
The Cross-Sectional Association between Consumption of the Recommended Five Food Group “Grain (Cereal)”, Dietary Fibre and Anthropometric Measures among Australian Adults
Authors: Fayet-Moore Flavia , Petocz Peter , McConnell Andrew , Tuck Kate , Mansour Marie
Published: February 2017

The Australian Dietary Guidelines recommended “grain (cereal)” core food group includes both refined and whole grain foods, but excludes those that are discretionary (i.e., cakes). We investigated the association between daily serves from the “grain (cereal)” group and its effect on fibre and adiposity. Data from Australian adults in the 2011–2012 National Nutrition and Physical Activity Survey were used (n = 9341). Participants were categorised by serves of core grain foods and general linear models were used to investigate the effect of demographic, socioeconomic, and dietary covariates on waist circumference, body mass index (BMI) and fibre intake. Compared to core grain avoiders (0 serves), high consumers (6+ serves/day) were: more likely male and socially advantaged, had a healthier dietary pattern, less likely dieting, overweight or obese, and were at lower risk of metabolic complications. After adjustment for age, sex and energy intake, there was an inverse relationship between core grain serves intake and BMI (p < 0.001), waist circumference (p = 0.001) and a positive relationship with fibre (p < 0.001). Model adjustments for diet and lifestyle factors resulted in a smaller difference in waist circumference (p = 0.006) and BMI (p = 0.006). Core grain serves was significantly associated with higher fibre, but marginally clinically significant for lower adiposity.
Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis
Authors: Cañete Ana , Cano Elena , Muñoz-Chápuli Ramón , Carmona Rita
Published: February 2017

Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent regulator of patterning during embryonic development, as well as being necessary for adult tissue homeostasis. Vitamin A deficiency during pregnancy increases risk of maternal night blindness and anemia and may be a cause of congenital malformations. Childhood Vitamin A deficiency can cause xerophthalmia, lower resistance to infection and increased risk of mortality. RA signaling appears to be essential for expression of genes involved in developmental hematopoiesis, regulating the endothelial/blood cells balance in the yolk sac, promoting the hemogenic program in the aorta-gonad-mesonephros area and stimulating eryrthropoiesis in fetal liver by activating the expression of erythropoietin. In adults, RA signaling regulates differentiation of granulocytes and enhances erythropoiesis. Vitamin A may facilitate iron absorption and metabolism to prevent anemia and plays a key role in mucosal immune responses, modulating the function of regulatory T cells. Furthermore, defective RA/RARα signaling is involved in the pathogenesis of acute promyelocytic leukemia due to a failure in differentiation of promyelocytes. This review focuses on the different roles played by vitamin A/RA signaling in physiological and pathological mouse hematopoiesis duddurring both, embryonic and adult life, and the consequences of vitamin A deficiency for the blood system.
Certain Grain Foods Can Be Meaningful Contributors to Nutrient Density in the Diets of U.S. Children and Adolescents: Data from the National Health and Nutrition Examination Survey, 2009–2012
Authors: Papanikolaou Yanni , Fulgoni Victor
Published: February 2017

Grain foods may play an important role in delivering nutrients to the diet of children and adolescents. The present study determined grain food sources of energy/nutrients in U.S. children and adolescents using data from the National Health and Nutrition Examination Survey, 2009–2012. Analyses of grain food sources were conducted using a 24-h recall in participants 2–18 years old (N = 6109). Sources of nutrients contained in grain foods were determined using U.S. Department of Agriculture nutrient composition databases and excluded mixed dishes. Mean energy and nutrient intakes from the total diet and from various grain foods were adjusted for the sample design using appropriate weights. All grains provided 14% ± 0.2% kcal/day (263 ± 5 kcal/day), 22.5% ± 0.3% (3 ± 0.1 g/day) dietary fiber, 39.3% ± 0.5% (238 ± 7 dietary folate equivalents (DFE)/day) folate and 34.9% ± 0.5% (5.6 ± 0.1 mg/day) iron in the total diet in children and adolescents. The current analyses showed that certain grain foods, in particular breads, rolls and tortillas, ready-to-eat cereals and quick breads and bread products, are meaningful contributors of folate, iron, thiamin, niacin and dietary fiber, a nutrient of public health concern as outlined by the 2015–2020 Dietary Guidelines for Americans. Thus, specific grain foods contribute to nutrient density and have the potential to increase the consumption of several under-consumed nutrients in children and adolescents.
S‐Allylmercaptocysteine Attenuates Cisplatin‐Induced Nephrotoxicity through Suppression of Apoptosis, Oxidative Stress, and Inflammation
Authors: Zhu Xiaosong , Jiang Xiaoyan , Li Ang , Zhao Zhongxi , Li Siying
Published: February 2017

Cisplatin is a potent chemotherapeutic agent, but its clinical usage is limited by nephrotoxicity. S‐allylmercaptocysteine (SAMC), one of the water‐soluble organosulfur garlic derivatives, has antioxidant and anti‐inflammatory properties and plays an important role in protecting cells from apoptosis. This study aims to examine the protective effects of SAMC on cisplatin nephrotoxicity and to explore the mechanism of its renoprotection. Rats were treated with cisplatin with or without pre‐treatment with SAMC. Renal function, histological change, oxidative stress markers and antioxidant enzyme activities were investigated. Apoptotic marker, nuclearfactor (NF)‐κB activity, expression of nuclear factor erythroid 2‐related factor 2 (Nrf2), NAD(P)H:quinone oxidoreductase 1 (NQO1) and inflammatory cytokines were also examined. The effect of SAMC on cell viability and apoptosis was examined in cultured human kidney (HK‐2) cells. SAMC was confirmed to significantly attenuate cisplatin‐induced renal damage by using histological pathology and molecular biological method. Pre‐treatment with SAMC reduced NF‐κB activity, up‐regulated Nrf2 and NQO1 expression and down‐regulated inflammatory cytokine levels after cisplatin administration. Cisplatin‐induced apoptosis in HK‐2 cells was significantly attenuated by SAMC. Thus our results suggest that SAMC could be a potential therapeutic agent in the treatment of the cisplatin‐induced nephrotoxicity through its anti‐apoptotic, anti‐oxidant and anti‐inflammatory effects.
A Feasibility Study of Taste & See: A Church Based Programme to Develop a Healthy Relationship with Food
Authors: Patel Riya , Lycett Deborah , Coufopoulos Anne , Turner Andy
Published: February 2017

Holistic approaches which include a religious element are a promising intervention within obesity, but have not been explored in the UK. Objective: To conduct a feasibility study of a three-month, Christian-based intuitive-eating programme in a church. Methods: A total of 18 adults participated. Ethical approval was granted by Coventry University Ethics Committee. Participant and facilitator experience was investigated qualitatively. Results showed participants accepted the programme and engaged well with its spiritual component. Lay facilitators managed to adequately run the programme, although some difficulties identified training needs. Clinical, psychological and spiritual measures were analysed using intention to treat; baseline observation carried forward to input missing data. Mental well-being, anxiety, depression, quality of life, pain/discomfort uncontrolled-eating, emotional-eating, cognitive-restrained-eating, intuitive-eating and Body Mass Index (BMI) improved significantly post-intervention. There were improvements in spiritual well-being, and reductions in energy, fat and saturated fat intake. Between the end of the intervention and a six-month follow-up, there were no statistically significant changes. However, the extent that weight and BMI returned to baseline levels meant that the reduction from baseline was no longer significant or clinically important. Mean changes in other variables, including uncontrolled eating, emotional eating, mental well-being and anxiety remained statistically improved from baseline. At six-month follow-up, improvements in intuitive eating were fully sustained at this time point and total fat, saturated fat and sugar intake had reduced further even though these values did not reach statistical significance. Conclusion: It is feasible to recruit to, deliver and evaluate Taste & See in a UK church, with lay volunteers. Clinical outcomes were positive, but a larger, controlled study is needed.
Combined Usage of TanDEM-X and CryoSat-2 for Generating a High Resolution Digital Elevation Model of Fast Moving Ice Stream and Its Application in Grounding Line Estimation
Authors: Kim Seung , Kim Duk-jin
Published: February 2017

Definite surface topography of ice provides fundamental information for most glaciologists to study climate change. However, the topography at the marginal region of ice sheets exhibits noticeable dynamical changes from fast flow velocity and large thinning rates; thus, it is difficult to determine instantaneous topography. In this study, the surface topography of the marginal region of Thwaites Glacier in the Amundsen Sector of West Antarctica, where ice melting and thinning are prevailing, is extracted using TanDEM-X interferometry in combination with data from the near-coincident CryoSat-2 radar altimeter. The absolute height offset, which has been a persistent problem in applying the interferometry technique for generating DEMs, is determined by linear least-squares fitting between the uncorrected TanDEM-X heights and reliable reference heights from CryoSat-2. The reliable heights are rigorously selected at locations of high normalized cross-correlation and low RMS heights between segments of data points. The generated digital elevation model with the resolved absolute height offset is assessed with airborne laser altimeter data from the Operation IceBridge that were acquired five months after TanDEM-X and show high correlation with biases of 3.19 m and −4.31 m at the grounding zone and over the ice sheet surface, respectively. For practical application of the generated DEM, grounding line estimation assuming hydrostatic equilibrium was carried out, and the feasibility was seen through comparison with the previous grounding line. Finally, it is expected that the combination of interferometry and altimetery with similar datasets can be applied at regions even with a lack of ground control points.