bluuebunny/crossref_metadata_2025 huggingface dataset:
Paternal Leave and Fathers’ Mental Health: A Rapid Literature Review
Authors: Philpott Lloyd Frank , Goodwin John , Saab Mohamad M.
Published: March 2022

Background:

Several countries have introduced paternal leave policies in order to encourage and involve fathers in caregiving. Besides supporting fathers’ involvement, paternal leave may have other consequences such as health improvements. Paternity leave could potentially improve mental health outcomes by reducing stress and anxiety associated with work–family conflict. It can be hypothesized that paternal leave has a positive effect on men’s mental health; however, there have been no recent attempts to review the literature pertaining to such outcomes.

Purpose:

The aim of this rapid review of the literature was to evaluate the evidence from studies that explored the effect of paternal leave on men’s mental health.

Design:

Rapid literature review

Methods:

The review was guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Electronic databases CINAHL Plus with Full Text, Academic Search Complete, MEDLINE, APA PsycArticles, APA PsycInfo, Social Sciences Full Text (H.W. Wilson), SocINDEX with Full Text, and ERIC were searched for studies that met the inclusion criteria.

Findings:

A total of 337 records were identified from the electronic database search. Nine studies met the inclusion criteria. The findings suggest that fathers experience mental health benefits as a result of availing of parental leave. The length of leave availed by fathers had an impact on their mental health, with longer duration of paternity leave associated with higher levels of mental well-being. Flexible leave impeded fathers from fully engaging in their paternal role or their employment duties.

Conclusion:

The mental health benefits of parental leave usually associated with mothers are also extended to fathers, highlighting the importance of this statutory entitlement.
Analisis pendapatan dan konsumsi petani karet di Desa Sungai Ulak Kecamatan Nalo Tantan Kabupaten Merangin
Authors: Prasetyo Bayu , Syaparuddin Syaparuddin , Rahmadi Selamet
Published: March 2022

This study aims: 1). To measure and analyze the income of rubber farmers in Sungai Ulak Village, Nalo Tantan District, Merangin Regency, 2). To measure and analyze the consumption issued by rubber farmers in Sungai Ulak Village, Nalo Tantan District, Merangin Regency and 3). the effect of income on consumption issued by rubber farmers in Sungai Ulak Village, Nalo Tantan District, Merangin Regency. The analytical method used in this research is quantitative descriptive analysis and simple linear regression analysis.Based on the results of the study concluded. The income of rubber farmers has a positive and significant effect on α = 5% one-way test on the total consumption of rubber planters in Sungai Ulak Village, Nalo Tantan District, Merangin Regency with a regression coefficient value of 0.836425.
Hemoptysis in an Adolescent with EVALI
Authors: Reynolds Chelsea , Staples Heather
Published: March 2022

Vaping associated lung injury (EVALI) has increased in prevalence after
first being noted in an outbreak among teenagers in 2019. Vaping
involves the use of a heating device to aerosolize a product, typically
nicotine or more recently, cannabinoids. Products that contain
cannabinoids, such as CBD oil, are being used more as these products are
easy to obtain and are typically less expensive. The clinical
manifestations of EVALI are widespread and include respiratory symptoms
as well as cardiogenic, gastrointestinal, and constitutive symptoms.
EVALI rarely presents with hemoptysis as one of the main presenting
symptoms, especially in an adolescent. This case will discuss EVALI with
associated hemoptysis in a teenager secondary to vaping cannabinoid oil.
Diagnostic Accuracy of Cardiac Computed Tomographic Angiography and Transesophageal echocardiography in Evaluation of Patients with Prosthetic paravalvular leakage
Authors: Hassan Amr Youssef , Kandil Hossam Ibrahim , Salem Mohamed Ali , Mohamed Ahmed Shehata , Kassem Hussien Heshmat
Published: March 2022

Purpose: Computed Tomography (CT) scan has been well addressed
to provide a diagnostic information for patients with prosthetic heart
valve dysfunction. However, its role in the assessment of patients with
prosthetic paravalvular leakage (PVL) has not been studied thoroughly.
So, this study was conducted to assess the feasibility, reproducibility,
and accuracy of CT for diagnosis of prosthetic PVL using surgical
findings as the reference standard. Materials and methods: This
was a prospective cohort study that was conducted on 26 consecutive
patients with suspected prosthetic PVL who underwent both
transesophageal echocardiography (TEE) and 64-slice ECG-gated CT. The
gold standard was the intraoperative findings. Surgery was performed in
twenty-six patients. Results: There was an excellent degree of
agreement between CT and intraoperative findings for diagnosis,
localization of prosthetic PVL. The perimeter of prosthetic PVL measured
by CT was strongly correlated with echocardiographic severity of PVL by
TEE (Spearman’s Correlation Coefficient, r = 0.83, P value = 0.0014).
Conclusion: This study demonstrates that cardiac CT showed
comparable diagnostic accuracy to TEE and intraoperative findings for
the detection, localization, and assessment of severity of prosthetic
PVL. Moreover, CT was shown to be useful in detection of other findings
related to prosthetic cardiac valves.
Minimally invasive off-pump unroofing of left anterior descending artery myocardial bridge
Authors: morita shohei , Hiraoka Arudo , Yamauchi Shuichiro , Hayashida Akihiro , Sakaguchi Taichi
Published: March 2022

Currently, myocardial unroofing, coronary artery bypass grafting and
percutaneous coronary intervention are chosen as treatments for
myocardial bridge. We performed a male patient off-pump unroofing of
left anterior descending coronary artery with techniques of minimally
invasive surgery through the 4 intercoastal space.
Intraoperative coronary angiography was performed to evaluate residual
lesions. Since this treatment strategy does not require full
heparinization, it can be expected to reduce the amount of bleeding.
This procedure not only has small incision, but also has some major
advantages.
Hopf bifurcation analysis in the diffusive nutrient-microorganism model with time delay
Authors: Yuan Hailong , Wang Yadi
Published: March 2022

In this paper, the diffusive nutrient-microorganism model with time
delay subject to Neumann boundary conditions is considered. The effect
of time delay on the Hopf bifurcation and stability of positive constant
equilibrium in the partial differential equation (PDE) and ordinary
differential equation (ODE) models are analyzed. By choosing the time
delay as the bifurcation parameter, it is found that the positive
equilibrium is asymptotically stable when the delay is less than a
certain critical value and unstable when the delay is greater than this
value. In addition, it is also indicated that Hopf bifurcation occurs
when the delay passes through a family of critical values. And then, the
formulae to determine the direction of the Hopf bifurcation and the
stability of the bifurcating periodic solutions by applying the normal
form theory and center manifold theorem for partial differential
equation are derived. Finally, to support our analytical results
obtained for the ODE and PDE model with time delay, some numerical
simulations are also included.
“Impact of covid 19 pandemic on maternofetal outcome in pregnant women with severe anemia:a retrospective case control study”
Authors: Singh Meenakshi , Puri Manju , CHAUDHARY VIDHI , GS TRIVENI , KAPUR AISHWARYA , gunjan GUNJAN , PATEL MANISHA , KUMARI VINITA
Published: March 2022

Objective: To study the impact of COVID 19 pandemic on the prevalence,
clinical profile, and pregnancy outcomes of women with severe anaemia.
Design: Retrospective Case Control study Setting: Department of
Obstertrics ,Tertiary care hospital of Delhi Population:Antenatal women
>26 weeks and Hemoglobin<7 gm% Methods: After
satisfying inclusion and exclusion criteria, cases were taken for a
duration of six months during COVID pandemic, covid cases and controls
from period six months post covid. Main outcome measures: Prevalence of
anemia, Anemia indices and maternofetal outcome. Results: Total 4031
women delivered in study period compared to 6659 in control period.
74.7% and 51.6% were anaemic in study and control groups respectively
(p < 0.001). Mean hemoglobin level was significantly lower in
cases compared to the controls. Microcytic hypochromic anemia was most
common morphological type of anemia in both groups. Serum ferritin,
serum iron, serum B12 and folic acid levels among cases were
significantly (p<0.05) lower as compared to controls. Odds of
foetal growth restriction was 48% higher among cases as compared to
controls. The odds ratio of new-born complications such as low birth
weight 2.49 (95%CI: 1.04-5.91) and need for nursery or NICU admission
4.84 (95%CI: 0.48-48.24) was higher in cases as compared to controls.
Low birth rate was higher in cases and was found to be statistically
significant. Conclusion: India needs to focus on minimizing the indirect
effects of the pandemic on the maternal and perinatal outcomes. Funding:
none
Recent Advances and Limitations in Management of COVID-19 - An Update
Authors: Poola Anushka , Prabhu Prithvi , P Monika , K Samrat
Published: March 2022

In the last two years, SARS-CoV-2 infection, commonly called COVID-19,
has taken a jump from being rarely talked about to becoming a household
name. Making it to history as the 5th global pandemic, this public
health crisis has taken millions of lives all over the world. Right from
the time of identification of patient zero, the pandemic has been a
series of waves of infection, causing a domino effect whose impact has
been felt in all walks of life. Global efforts have been underway to
combat this pandemic and minimize its repercussions, resulting in the
development of efficient vaccines and drugs to control and treat the
disease. However, making the benefits of these efforts available to
everyone and walking the path towards the end of the pandemic remains a
challenge. Keeping this in view, this review intends to present aspects
of sequential development of the pandemic, different types of variants,
risks associated with different categories of population, drugs
currently in use, recent advancements in diagnostics and treatment, and
the challenges that continue to remain in overcoming this pandemic.
However, the task of controlling and managing the impact of such a
massive pandemic goes well beyond the boundaries of what present-day
technology in the field of medicine and health-care can offer. A
collaborative and integrative approach between academic, scientific,
social, and economic factors, along with close supervision and
reinforcement of the current public safety protocols, can help to ensure
a better management strategy to control the progression of COVID-19.
Relationship between single nucleotide polymorphism of IGF-1 gene in Nile tilapia(Oreochromis niloticus)and weight gain
Authors: ZHANG HANCHEN , Rambhau Jawanjal Namrata , Chae Jun Young , Yoo Byung Hwa , Lee Hyung Ho
Published: March 2022

Production and consumption of Nile tilapia (Oreochromis niloticus) have
been growing. Insulin like growth factors-1(IGF-1) is a hormone that
affects the weight of animals. To produce high-quality Nile tilapia,
traditional breeding combined with molecular marker technology to assist
selective breeding has long become an effective means of cultivating new
fish strains. Moreover, molecular markers or genes related to important
economic traits can be found with the help of molecular-assisted
selection breeding. A total of 152 fish fin samples were collected from
Janghang Fishing Ground and classified according to their weight and sex
(good male-35, bad male-35, medium male-12, good female-35, and bad
female-35). A total of 9 SNPs (single nucleotide polymorphism) of Nile
tilapia IGF-1 were identified in this study, One SNP is in the promoter,
three SNPs are in the 5’UTR, and five SNPs are in the 3’UTR. By
analyzing the correlation between body weight and GBs, effective GBs
were selected. This study aims to improve the Nile tilapia species with
the help of molecular markers in the future and to select fast-growing
new strains, shorten the breeding cycle, achieve maximum economic
benefits, and realize the important economic traits of tilapia. The best
combination and strengthened tilapia breeding technology system provides
a reference for molecular genetics. It also provides a guarantee and
basis for future human protection of species diversity, food and
nutrition safety, and selection of high-quality species breeding.
Plasma Exosomes Confer Hypoxic Pulmonary Hypertension by Transferring LOX-1 Cargo
Authors: Huang Ning , Wang Di , Zhu Tian-Tian , Ge Xiao-Yue , Liu Hong , Yao Mao-Zhong , Guo Yan-Zi , Peng Jun , Zhang Zheng , Hu Chang-Ping
Published: March 2022

ABSTRACT Background and Purpose The pulmonary vascular remodeling (PVR),
the pathological basis of pulmonary hypertension (PH), entails pulmonary
artery smooth muscle cells (PASMCs) phenotypic switching, but
appreciation of the underlying mechanisms is incomplete. Exosomes, a
novel transfer machinery enabling delivery of its cargos to recipient
cells, have been recently implicated in PH. The two critical questions
of whether plasma-derived exosomes drive PASMCs phenotypic switching and
what cargo the exosomes transport, however, remain unclear. Experimental
Approach PH is induced by exposure of rats to chronic hypoxia (10% O2,
3 weeks). Exosomes were isolated and purified from rat plasma by
ultracentrifugation. Exosomal LOX-1 was assessed by transmission
electron microscopy and Western blotting. PASMCs phenotypic switching
was determined by Western blotting, immunofluorescence staining and flow
cytometry. Key Results We characterized lectin like oxidized low-density
lipoprotein receptor-1 (LOX-1) as a novel cargo of plasma-derived
exosomes in PH. With LOX-1 knockout (Olr1-/-) rats-derived exosomes, we
demonstrated that exosomal LOX-1 could be transferred into PASMCs and
thus elicited cell phenotypic switching. Of importance, Olr1-/- rats
exhibited no cell phenotypic switching and developed less severe PH, but
administration of wild type rather than Olr1-/- exosomes to Olr1-/- rats
recapitulated the phenotype of PH with robust PASMCs phenotypic
switching. We also revealed that exosomal LOX-1 triggered PASMCs
phenotypic switching, PVR and ultimately PH via ERK1/2-KLF4 signaling
axis. Conclusion and Implications This study has generated proof that
plasma-derived exosomes confer PH by delivering LOX-1 into PASMCs.
Hence, exosomal LOX-1 represents a novel exploitable target for PH
prevention and treatment.
Chromosome-level genome assembly of Acanthogobius ommaturus provides insights into evolution and lipid metabolism
Authors: Song Na , Zhao Linlin , Pan yu , Sun zhicheng , Gao Tianxiang
Published: March 2022

Acanthogobius ommaturus is a large, economically important annual fish
widely distributed in coastal and estuarine areas. The adults will die
after breeding, and its life cycle is only one year. The first
chromosome-level genome assembly of A. ommaturus was obtained by PacBio
and Hi-C sequencing in this study. The final genome assembly after Hi-C
correction was 921.49 Mb, with contig N50 and scaffold N50 values of
15.70 Mb and 40.99 Mb, respectively. The assembled sequences were
anchored to 22 chromosomes by using Hi-C data. A total of 18,752
protein-coding genes were predicted, 97.90% of which were successfully
annotated. A. ommaturus is phylogenetically closely related to
Periophthalmodon magnuspinnatus, Boleophthalmus pectinirostris,
diverging approximately 31.9 million years ago with the two goby
species. The A. ommaturus genome displayed 597 expanded and 3,094
contracted gene families compared with the common ancestor. A total of
1155 positive selected genes (PSGs) (p < 0.05) were
identified. Based on comparative genomic analyses, we obtained several
expanded genes such as ACSBG2, LRP1, LRP6 and ZNF638 involved in lipid
metabolism. Totally twenty candidate genes were identified under
positive selection, which associated with lifespan including ERCC6,
IGF1, POLG, and TERT. Interspecific collinearity analysis showed a high
genomic synteny between A. ommaturus and Periophthalmodon
magnuspinnatus. The effective population size of A. ommaturus decreased
drastically during 200-100Ka because of Guxiang ice age, then increased
gradually following warm periods. This study provides pivotal genetic
resources for in-depth biological and evolutionary studies, and
underlies the molecular basis for lipid metabolism.
Reduced HMGB1 expression contributed to lapatinib-induced cutaneous injury
Authors: Jiang Liyu , Zeng Yan , Ai Leilei , Yan Hao , Yang Xiaochun , Luo Peihua , Yang Bo , Xu Zhifei , He Qiaojun
Published: March 2022

Background and Purpose Lapatinib, a widely-used dual inhibitor of
EGFR/ERBB1 and HER2/ERBB2 effectively targeting HER2 positive breast
cancer, has been seriously limited due to cutaneous toxicity. However,
the specific mechanism of lapatinib-induced cutaneous toxicity has not
been clarified, leading to a lack of effective strategy targets to
improve clinical safety. Here, we aimed to identify molecular mechanism
occurs in this process and strive for effective intervention strategies
against lapatinib-induced cutaneous side effects. Experimental and
Approach C57BL/6 mice were subjected to lapatinib via intragastric
administration, serum was used for ELISA assay, skin tissue was
collected and performed with histopathological analysis. Apoptotic assay
was analyzed in HaCaT and NHEK cell lines, comet assay was conducted to
measure the damage of DNA, real-time PCR was used to assess the level of
HMGB and inflammatory factors. Key Results We found that lapatinib could
induce mitochondrial dysfunction, lead to DNA damage and finally cause
apoptosis of keratinocytes. In addition, we found that lapatinib could
induce aberrant immune response and promote the release of inflammatory
factors in vitro and in vivo. Mechanistically, downregulated expression
of HMGB1 played a critical role in these toxic reaction processes.
Delightfully, we found that saikosaponin A could significantly rescue
the reduced HMGB1 transcription, which could alleviate lapatinib-induced
DNA damage, inhibit keratinocyte apoptosis and further prevent toxicity
of lapatinib in mice. Conclusion and Implications Our study provided
molecular mechanism of lapatinib-induced cutaneous toxicity, and shed
new light on the prevention of cutaneous adverse drug reactions induced
by EGFR inhibitors.
Mechanism and kinetics of propylene epoxidation by H2 and O2 on the dual-site Au-Ti catalyst
Authors: Du Wei , Zhang Zhihua , Tang Yanqiang , Wang Gang , Wang Qianhong , Song Nan , Duan Xuezhi , Zhou Xinggui
Published: March 2022

Propylene epoxidation by H2 and O2 for propylene oxide (PO) production
has many advantages over other processes, and Au/TS-1 has the best
catalytic performance. In this study, the mechanism is investigated and
the kinetics is established for Au/TS-1-B, which has a stable catalytic
performance. We found for the first time that the Ti sites on the TS-1
surface, rather than those at the Au-Ti interface are the main sites for
PO formation, and HOOH rather than *OOH is the main oxidizing species.
In addition, we show by experiment that acrolein is formed mainly on Au
rather than on Ti sites, and H2 boosts significantly the formation rate.
The proposed kinetics agrees well with the experiment. This study
improves the understanding of the mechanism of propylene epoxidation on
Au-Ti catalyst, and will facilitate the design and development of
efficient catalysts for industrial application.
Whither Chemical Engineering?
Authors: Ramkrishna Doraiswami , Braatz Richard
Published: March 2022

The strong core base in chemical engineering during the latter half of
the 20th century enabled chemical engineers to contribute extensively to
many areas outside of the traditional. The depth of such involvement has
led researchers to confront questions much more engaging to the field of
application, thus adopting and cultivating expertise more native to it
than to secure chemical engineering as a discipline. The progress of
knowledge in science and engineering must leave a strong trail of
fundamental understanding through developed methodologies that can
assist in continuing progress. If this tenet is acknowledged, this
article yields considerable scope for discussion on whether chemical
engineering research is continuing to provide for a growing core that
has endowed chemical engineers with the ability to formulate and solve
important societal problems in which material systems undergo changes in
composition and energy. We discuss opportunities for hopefully serving
the issues of concern.
Soft-Modes Guided Pharmacophore Modeling Succeeds in Identification of Potent MDM2 Inhibitors
Authors: ÇARSIBASI NIGAR , Lokmaci Elif
Published: March 2022

Targeting the interaction between tumor suppressor p53 and murine double
minute 2 (MDM2) protein has been an attractive therapeutic strategy of
recent cancer research. There are a few number of MDM2-targeted
anticancer drug molecules undergoing clinical trials right now, however
none of them have been approved so far. Recently, we analyzed the global
dynamics of MDM2 and the conformational changes it undergoes upon ligand
binding in cases of both native ligand p53 and small molecule
inhibitors. In this study, we employed a new approach in which global
dynamics of MDM2 obtained by elastic network models are used as a guide
in the generation and validation of the ligand-based pharmacophore model
prior to virtual screening in search for novel MDM2 inhibitors. Then, we
carried out virtual screening, rigid and induced-fit molecular docking,
which accounts for the very flexible and intrinsically disordered nature
of MDM2, to capture several hit molecules exhibiting high affinity. We
used the knowledge of the binding mechanism while creating the
induced-fit docking criteria which can fine tune the docking protocol.
Application of a rigorous molecular mechanics-generalized born surface
area (MM-GBSA) method provided a more accurate prediction of the binding
free energy values. We identified two leading hit molecules which have
shown better docking scores, binding free energy values and drug-like
molecular properties as compared to seven clinical trial MDM2 inhibitor
molecules. These hits exhibited extra intermolecular interactions with
MDM2, indicating a stable complex formation. Therefore, combined
computational strategy employed in generating a pharmacophore model
based on the active available ligands undergoing clinical trials and
validating the model by the conformational dynamics background to screen
libraries can be a promising tool in the initial stage of drug design
for the discovery of potential new hits.
Evolution mechanism for the field resistance of Corynespora cassiicola to benzimidazoles
Authors: Mao Yushuai , Li Haoran , Liu Tingting , Zhao Baoquan , Cai Yiqiang , Wang Jianxin , Zhou Mingguo , Duan Yabing
Published: March 2022

Cucumber target leaf spot caused by Corynespora cassiicola has
devastated greenhouse cucumber production. In our previous study, the
monitoring of C. cassiicola resistance to carbendazim was carried out
and a large number of resistant isolates which conferred various
mutations (M163I&E198A, F167Y&E198A, F200S&E198A or E198A) in the
β-tubulin of C. cassiicola were detected in the field. However, the
single-point mutations M163I, F167Y, and F200S have remained undetected
in the field. To investigate the resistance evolution mechanism of C.
cassiicola to benzimidazoles, site-directed mutagenesis was used to
construct alleles with single-point mutation M163I, F167Y, F200S, E198A,
and double mutation M163I&E198A, F167Y&E198A or F200S&E198A in
β-tubulin. Through PEG-mediated protoplast transformation, all the
mutants except for the M163I mutation were obtained and conferred
resistance to benzimidazoles. A similar sensitivity to benzimidazoles
was observed between the F167Y and F200S mutations. However, in
comparison to the F167Y or F200S mutations, double mutations
(M163I&E198A, F167Y&E198A, F200S&E198A) and single mutation E198A
caused significantly decreased sensitivity to benzimidazoles. The
sensitivity to benzimidazoles for the double mutations (M163I&E198A,
F167Y&E198A, F200S&E198A) did not differ from the single mutation
E198A. Based on biological characteristics, the findings showed that the
mutants conferring the F167Y or F200S mutations suffered fitness
penalty, but not the mutants conferring the double mutations
(M163I&E198A, F167Y&E198A, F200S&E198A) or the single mutation E198A.
Thus, we concluded that to avoid the intrinsic fitness penalty and
survive in the field, the double mutations (F167Y&E198A, F200S&E198A)
evolved from the single mutations F167Y and F200S, respectively, and not
the single mutation E198A.
Preferential precipitation for reducing acidic variant content in monoclonal antibody pools
Authors: Rumanek Tomasz , Kolodziej Michal , Piatkowski Wojciech , Antos Dorota
Published: March 2022

Microheterogeneity of mAbs can impact their activity and stability.
Formation of charge variants is considered as the most important source
the microheterogeneity. In particular, controlling the content of the
acidic species is often a major importance for the production process
and the regulatory approval of therapeutic proteins. In this study, the
preferential precipitation process is developed for reducing the content
of acidic variant in mAb downstream pools. The process design was
preceded by determination of phase behavior of mAb variants in the
presence of different precipitants. It is shown that the presence of
polyethylene glycol (PEG) in protein solutions favors precipitation of
acidic variants of mAbs. Precipitation yield is influenced by the
variant composition in the mAb feed solutions, the concentration of the
precipitant and the protein and the ionic strength of the solutions. To
improve yield, the precipitate is repeatably dissolved and recycled to
the precipitation process. The final product is as a mixture of
supernatants pooled together from the recycling steps, in which the
content of the acid variant is reduced. In addition, mAb aggregates
present in the feed solutions accumulate in the precipitate., which is
discarded as a waste. Such an approach can be potentially used either
instead or in a combination with chromatography for adjusting the acidic
variant content of mAbs, which can benefit in improvement in throughput
and reduction in manufacturing costs.
Continuous synthesis of atomically dispersed Rh supported on MgAl2O4 in hydrogen production from liquid hydrocarbon
Authors: Xue Qiangqiang , Yan Binhang , Wang Yujun , Luo Guangsheng
Published: March 2022

Single-atom catalysts with optimal atom utilization and outstanding
activity have penetrated the frontier of heterogeneous catalysis.
However, the large-scale synthesis of this class of catalysts is still a
bottleneck for their industrialization. Herein, we suggest a two-stage
micro-dispersion approach to synthesize mesoporous MgAl2O4-supported
atomically dispersed Rh, which is more competitive than the batch method
for boosting the uniform dispersion of Rh. By increasing the Rh loading,
SACs (< 0.05wt%), SACs + NPCs (0.05–0.17 wt%), and NPCs
(0.17–1.10 wt%) were obtained and then characterized by the HADDF-STEM
technique. For n-octane steam reforming, the TOF of the SAC (0.01 wt%)
was approximately 30 times that of the NPC (1.10 wt%), while the Rh
amount of SAC was only 3% that of the NPC for the same fuel conversion.
Under a high-temperature (750 ℃) steam atmosphere for 15 h, the hydrogen
formation rate only declined from 25.1 to 23.8 mol/mol-C8H18.
Hospital Design Evaluation Model Using Entropy and Heuristic Theories
Authors: Hassanain Amr , ELDOSOKY A.A. MOHAMED , SOLIMAN M. AHMED
Published: March 2022

The design of a healthcare facility is one of the most challenging tasks
because of the complexity associated with these facilities. The quality
of healthcare is the primary objective of the healthcare facility. The
design of healthcare facilities and their environments directly
influence the facility’s productivity, the economic performance of the
organisation, the experienced clinical outcomes in the hospital, patient
and staff satisfaction, just to mention a few. The design of a
healthcare facility is essential for ensuring a serene healing
environment for the patients, which in turn influences their healing
rates, reduces the amount of time spent in the facilities, and impacts
their level of satisfaction with the care provided. In this study, the
collected standards were weighted using the entropy theory as a
weighting method for evaluating different departments in various
hospitals. In addition, the layout score has been measured using the
adjacent theory as one of the graph heuristic methods to be aware of the
department or the whole hospital can be redesigned to meet international
standards. The evaluation methodology is a step in the redesign process
to improve the current hospital to meet international standards. The
analysis of the results that our methodologies are applied in one
selected hospital in Egypt reflects the average of the satisfied
standards as 43%, standards that can be satisfied 24%, not applicable
standards 34% and the average layout score is 25%.
Effect of super-specialization in External Cephalic Version: A comparative study
Authors: Romero Javier Sánchez , Araico-Rodríguez Fernando , Herrera-Giménez Javier , Gallego-Pozuelo Rosa , Nieto-Díaz Anibal , Sanchez-Ferrer Maria lUISA
Published: March 2022

Objective: Compare the effectiveness and safety of the ECV when the
procedure is performed by senior experienced obstetricians or by
super-specialized professionals who composed a dedicated team. Design:
Longitudinal prospective analysis. Setting: 1st of January of 2018 and
31st of December of 2019. Population: Pregnant women with non-cephalic
presentation and no contraindication for vaginal delivery. Methods:
Longitudinal prospective analysis of ECV performed in a tertiary
hospital. From 1/1st/2018 to 10/1st/2019, ECV were performed by two
senior experienced obstetricians who composed the dedicated team for
ECV, designed as Group A. From 10/1st/2019 to 12/31st/2019, ECV was
performed by two seniors obstetricians, designed as Group B. Ritodrine
was administered during 30 minutes just before the procedure. Propofol
was used for sedation. Main Outcome Measures: ECV success rate, ECV
complication rate, cesarean section 24 h after ECV. Results: 186
pregnant women were recruited (150 patients in group A and 36 patients
in group B). ECV success rate increased from 47.2% (31.7-63.2) in Group
B to 74.0% (66.6-80.5) in Group A. The greatest increase in the success
rate of ECV was seen in nulliparae, from 38.5% (21.8-57.6) in group B
to 69.1% (59.4-77.6). Complications rate decreased from 22.2%
(11.1-37.6) in Group B to 9.3% (5.5-14.8) in Group A. Conclusions: The
introduction of an experienced dedicated team improves ECV success rate,
especially in primiparas, and it also reduces ECV complications rate.
Funding: The authors received no financial support for the research,
authorship, and/or publication of this article. Keywords: Sedation,
Experience, ECV, Breech presentation
Influence of weather on gobbling activity of male wild turkeys
Authors: Wightman Patrick , Martin James , Kilgo John C. , Rushton Emily , Collier Bret , Chamberlain Michael
Published: March 2022

Gobbling activity of Eastern wild turkeys (Meleagris gallopavo
silvestris; hereafter, turkeys) has been widely studied, focusing on
drivers of daily variation. Weather variables are widely believed to
influence gobbling activity, but results across studies are
contradictory and often equivocal, leading to uncertainty in the
relative contribution of weather variables to daily fluctuations in
gobbling activity. Previous works relied on road-based auditory surveys
to collect gobbling data which limits data consistency, duration, and
quantity due to logistical difficulties associated with human observers
and restricted sampling frames. Development of new methods using
autonomous recording units (ARUs) allows researchers to collect
continuous data in more locations for longer periods of time, providing
the opportunity to delve into factors influencing daily gobbling
activity. We used ARUs from 1 March to 31 May to detail gobbling
activity across multiple study sites in the southeastern United States
during 2014 – 2018. We used state-space modeling to investigate the
effects of weather variables on daily gobbling activity. Our findings
suggest rainfall, greater wind speeds, and greater temperatures
negatively affected gobbling activity, whereas increasing barometric
pressure positively affected gobbling activity. Therefore, when using
daily gobbling activity to make inferences relative to gobbling
chronology, reproductive phenology, and hunting season frameworks
stakeholders should recognize and consider the potential influences of
extended periods of inclement weather.
Adaptive Solutions to the Problem of Vulnerability During Sleep
Authors: Wichlinski Lawrence
Published: March 2022

ABSTRACT Sleep is a behavioral state whose quantity and quality
represent a trade-off between the costs and benefits of sleep versus the
costs and benefits of wakefulness. We humans need a brain/body state
that can fulfill basic biological functions, such as securing food,
water, and mates. But we must do so while conserving energy and
minimizing exposure to dangers that accompany an organism’s particular
ecological niche. Our species is particularly vulnerable during sleep
because of our reduced ability to monitor the environment for nighttime
predators and other environmental dangers. A number of variations in
sleep characteristics may have evolved to reduce this vulnerability,
both at the individual level and group level. The goals of this review
paper are: (1) to explore such variations, including clinical disorders
like insomnia and circadian rhythm disturbances, which may have adaptive
utility in terms of enhancing detection of external threats, and (2) to
consider cultural developments that improve vigilance and reduce
vulnerability during sleep and the night.
Effects of Water, Nitrogen, and Phosphorus Additions on Root Growth Strategies of Stipa breviflora under Drought Conditions
Authors: Fan Ruyue , Lv Shijie , Li Qingfeng
Published: March 2022

Root growth strategies are important to predict plant – soil
interactions under nutrient-limited soil environments. A dominant
species Stipa breviflora is found to develop cluster fragmentation in
the arid and semi-arid areas of China, where water, nitrogen and
phosphorus are the most important limiting factors to plant growth.
Here, we aimed to assess how water, N, P additions and their
interactions, and cluster fragmentation affect root growth traits in a
greenhouse experiment to reveal the adaptation of S. breviflora under
drought conditions. A standard Taguchi L8(27) arrays design was
conducted with four factors such as nitrogen (N), phosphorus (P) and
water (W) and cluster fragmentation (C) and three interactions (N × P, N
× W and P × W). Each of four factors had two levels (N1 = 15 mg N / kg,
N2 = 120 mg N / kg, P1 = 2 mg P2O5 / kg, P2 = 24 mg P2O5 / kg, W1 = 25
% ~ 30 % field moisture capacity of mixture (FMC), W2
= 75 % ~ 80 % FMC, C1 = individual with single ramet,
C2= individual with three ramets).Water was the most important
contributor to S. breviflora root system growth, while cluster
fragmentation was the second contributor, followed by N and P in order.
W2 and P2 both promoted root growth, whereas N2 significantly inhibited
root growth. Moreover, under drought condition, N2 induced its roots
developing an acquisition resource use strategy for escaping adverse
environments compared to N1. While under sufficient P condition, W1
induced its roots developing an acquisition resource use strategy for
acquiring more resource. And cluster fragmentation is beneficial to
improving the adaptability of S. breviflora under low N condition.
CONTROL OF KAWAHARA EQUATION WITH OVERDETERMINATION CONDITION: THE UNBOUNDED CASES
Authors: Filho Roberto Capistrano , Sousa S. LUAN Soares de , GALLEGO A. FERNANDO
Published: March 2022

Abstract. In this manuscript we consider the internal control problem
for the fifth order KdV type equation, commonly called the Kawahara
equation, on unbounded domains. Precisely, under certain hypotheses over
the initial and boundary data, we are able to prove that there exists an
internal control input such that solutions of the Kawahara equation
satisfies an integral overdetermination condition. This condition is
satisfied when the domain of the Kawahara equation is posed in the real
line, left half-line and right half-line. Moreover, we are also able to
prove that there exists a minimal time in which the integral
overdetermination condition is satisfied. Finally, we show a type of
exact controllability associated with the “mass” of the Kawahara
equation posed in the half-line.
High SARS-CoV-2 IgG seroprevalence among pregnant Cameroun women 14 months after the beginning of the pandemic
Authors: Mansuy Jean Michel , Kenfack Martial , Burel Suzanne , Pollani Candice , Lebobo Marlise , Ekaé Célestin , Berry Antoine , Izopet Jacques
Published: March 2022

We found a seroprevalence of anti-SARS-CoV-2 IgG of 77% in a population
of Cameroonian pregnant women sampled 14 months after the start of the
COVID-19 pandemic. This high exposure to the virus requires a rethinking
of vaccine priorities in African countries. The value of vaccination
against COVID-19 should be considered at the local level based on
seroprevalence studies, but the expanded programme of vaccination
interrupted during the pandemic should be resumed urgently.
Birds and lizards of the Antilles: a re-evaluation of old evidence leads to new conclusions: A synthesis
Authors: Terborgh John
Published: March 2022

Predation regimes on many oceanic islands are known to be weak. Evidence
gathered in the 1970s and 1980s shows that Antillean anoles live at
higher densities on fewer resources, grow more slowly, reproduce later,
and live longer than mainland counterparts. Living at high densities
should select for the ability to subsist on minimum resource levels, the
definition of a superior resource competitor. These results imply that
island anoles, and by inference, birds, experience low predation but
intense competition, whereas mainland species experience the opposite.
Further support is found in the phenomenon of community saturation in
Antillean birds, an unexpected finding underlain by hyperdispersed body
size ratios within avian foraging guilds, low alpha diversity and low
species packing within guilds, all being evidence that these guilds are
structured by competition. Islands should thus not be regarded as havens
for weak competitors, but rather as refuges from predation. It follows
that intense predation regimes prevent island species from colonizing
mainlands, and that competition and/or low resource levels prevent
mainland species from colonizing islands. These predictions are
experimentally testable with lizards and if confirmed, could set island
biogeography on a new course.
Tacrolimus-Induced Systemic Drug Related Intertriginous and Flexural Exanthema after Hematopoietic Stem Cell Transplantation
Authors: Crowell Sara , Taylor Kimberly , Rangarajan Hemalatha , Abu-Arja Rolla , Pai Vinita , Harfmann Katya , Bajwa Rajinder
Published: March 2022

Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE),
previously known as “Baboon Syndrome,” is diagnosed if four or more of
the following criteria are met: symmetry, involvement of at least one
intertriginous zone, erythema of the gluteal, inguinal, or axillary
region, systemic exposure to a drug, and lack of systemic toxicity. A
first ever case of SDRIFE after HSCT is presented who was initially
treated for multiple recurrences of acute skin graft versus host
disease. SDRIFE should be considered in the differential diagnosis of
refractory GvHD and is easily treatable by avoiding the offending
medication
Additively Manufactured Cryogenic Microchannel Distillation Device for Air Separation
Authors: Bottenus Danny , Humble Paul , Burnett Russell , Harper Warren , Veldman Tim , Powell Michael , Barclay John , Ely James
Published: March 2022

The efficiency of air separation is tested using three different small
scale cryogenic distillation columns. The performance of a random packed
column is compared to the performance of two microchannel distillation
(MCD) columns that use thin wicking structures and gas flow channels to
achieve process intensification. The MCD columns tested include a
plate-type layered (PTL) column and an additively manufactured porous
honeycomb (AMPH) column. For columns with 25.4 cm of active height and
run under similar conditions, the packed, PTL, and AMPH columns achieved
approximate height equivalent of a theoretical plate (HETP) values of
5.5, 3.7, and 3.2 cm for nitrogen, and 5.9, 4.9, and 3.3 cm for argon.
The AMPH column can produce up to 0.4 SLM of 90+% purity oxygen with 12
W of cooling lift. These results demonstrate the feasibility of using
additive manufacturing to construct MCD devices and pave a way for
constructing novel MCD designs.
Effect of cervical pessary on pregnancy outcome in patients with twin pregnancies: a systematic review and meta-analysis
Authors: Wang Yue , Wu Jiaxing , Ma Di , Huang mingli
Published: March 2022

Conclusion The cervical pessary can extend the gestational week of
short-cervix twin pregnancy without clinical symptoms, reduce the
premature birth rate before 34 weeks of gestation, improve pregnancy
outcome, reduce neonatal mortality, reduce necrotizing enterocolitis
incidence, neonatal sepsis incidence, and improve neonatal outcome. For
patients with a cervical length less than 38mm, a cervical pessary can
be performed to extend the gestational week. For patients with a
cervical length less than 25mm, a cervical pessary can effectively
prolong the gestational age and improve the maternal and fetal outcomes.
The cervical pessary is safe for patients with twin pregnancies. Suggest
that twin-preganct-patients with CL<38mm should consider take
cervical pessary in advance. In terms of long-term efficacy, there is no
evidence of cervical support placement on the long-term maternal
prognosis. In terms of economic benefits, cervical support is better
than vaginal progesterone, but this conclusion still needs more research
to prov
Askin tumor as a secondary malignancy after childhood acute lymphoblastic leukemia
Authors: Toret Ersin , Ozdemir Zeynep Canan , Oztunali Cigdem , BOR OZCAN
Published: March 2022

We report the case of a 10-year-old girl with an Askin Tumor who had a
history of Acute Lymphoblastic Leukemia. Seven years after the diagnosis
of ALL, her family detected a mass on her left chest wall. An
ultrasound-guided tru-cut needle biopsy was performed and the diagnosis
of a primitive neuroectodermal tumor of the chest wall (Askin Tumor) was
finalized with histologic and genetic analysis. The risk of secondary
cancer is three to 10 times higher in childhood cancer survivors than
the general population. Patients who have several different types of
cancers should be tested for hereditary cancer syndromes.
Exploring of the prognostic value of eight immunohistochemical markers expressed in the tumor microenvironment and on Hodgkin Reed-Sternberg cells in pediatric patients with classical Hodgkin lymphoma
Authors: Zijtregtop Eline , Tromp Ilse , Dandis Rana , Zwaan Christian , Lam King , Meyer-Wentrup Friederike , Beishuizen Auke
Published: March 2022

Immunohistochemical markers are associated with treatment outcome in
adults with classical Hodgkin Lymphoma (cHL). Studies in children are
scarce and inconsistent. We investigated in 67 children with cHL,
whether the expression of CD15, CD30, PAX5, PD-1, PD-L1, CD68, CD163 and
TARC is associated with the event-free survival (EFS) and the interim
remission status. Low expression of PD-L1 was significantly associated
with complete remission at interim PET-scan. There was no association
between marker expression and EFS. Our data suggest a difference between
pediatric and adult cHL. This underlies the importance of future
research into specific molecular drivers in pediatric cHL.
EXPLORING AREAS OF IMPROVEMENT IN POSTNATAL CARE SERVICES IN A TERTIARY CARE HOSPITAL IN PAKISTAN
Authors: Mahmood Atiya , Muzaffar Arooj , Javed Ayesha , Eusaph Amna
Published: March 2022

Objective:To assess current quality of postnatal care in tertiary
hospital in Lahore to identify areas for further improvement.Design:It
was descriptive cross-sectional study which employed quantitative method
to collect and analyze data.Setting:Lady Aitchison Hospital-a tertiary
hospital in Lahore.Population:Ninety-six maternities admitted in wards
of Lady Aitchison hospital during December 2021 to January
2022.Method:After IRB approval, consent was taken from mothers selected
by random sampling and interviewed using Donabedian framework
performa.Outcome Measures:Satisfaction with structure,process and
outcome of delivery in postpartum mothers were assessed.Results:Among 96
mothers,56% were below 25 years of age,39% had secondary
education,with more than one child(71%) and 57% visited for the first
time.Majority of mothers,were given medicine timely(82%) and found
attitude(85%) and information(83%) provided by healthcare workers
helpful.Their subjective satisfaction rate with staff was
90%.However,there was lack of proper guidelines and facilities for
examination,limited counselling of mothers regarding neonatal care and
substandard interior of hospitals.Vital steps such as neonatal and
maternal abdominopelvic,general and wound examination were left out in
upto 30%. Information regarding danger signs of mothers and neonates
was not given to 69% and information on family planning was given in
only 28%.Contentment with infrastructure of hospital was subpar and it
was suggested that sanitary conditions of washrooms and paraphernalia
i.e.heaters and beds needed improvement.Conclusions:This study suggests
that although patients were satisfied by services of healthcare
workers,the infra-structure of hospital can be upgraded to provide
better quality facilities in terms of air-conditioning,washrooms and
well-designed areas for extensive examination of breast,pelvis,abdomen
and neonates with introduction of WHO guidelines for postnatal care.
An Experience using Venetoclax and Azacitidine in a Treatment-Naïve Adolescent with Acute Myeloid Leukemia Secondary to Myelodysplastic Syndrome
Authors: Tseng Jui-Ju , Chen Tsung-Chih , Liang Chiung-Wen , Huang Fang-Liang
Published: March 2022

Refractory/relapsed acute myeloid leukemia is an advanced hematological
malignancy with a poor prognosis in pediatric. The therapeutic options
are limited and has been slow development of therapies for this age
group. A combination of Venetoclax and Azacitidine therapy in newly
diagnosed elderly patients with acute myeloid leukemia and
refractory/relapsed disease has achieved impressive results. Whether
similar results can be attained in pediatric patients is unknown. We
present a case of adolescent girl with acute myeloid leukemia secondary
to myelodysplastic syndrome, who was deemed unfit to undergo
conventional chemotherapy and, was treated instead with the Venetoclax
and Azacitidine.