bluuebunny/crossref_metadata_2025 huggingface dataset:
Pênfigos na amazônia: aspectos clínicos, epidemiológicos e terapêuticos de pacientes atendidos em serviço de referência.
Authors: Alves Marcela Coutinho , Pires Carla Andréa Avelar , Lima Carla dos Santos , Duque Juliana Leão de Souza , Lima Caren dos Santos
Published: June 2021

O termo "pênfigo" é usado para descrever um grupo de doenças bolhosas autoimunes que comprometem a pele e as mucosas. É histologicamente caracterizado pela clivagem intraepidérmica e deposição de IgG na superfície dos ceratinócitos. Pênfigo vulgar (PV) e pênfigo foliáceo (PF) são as principais formas clínicas. Essa pesquisa objetivou identificar os aspectos clínicos, socio-demográficos e terapêuticos dos pacientes com diagnóstico de pênfigo. Para isso, foi realizada análise retrospectiva de prontuários médicos nos arquivos do ambulatório de Dermatologia da Universidade do Estado do Pará (UEPA) de janeiro de 2007 a janeiro de 2017. Foram identificados no período 19 pacientes com diagnóstico de pênfigo, dos quais 11 com PV e 8 PF, ambas as formas clínicas foram mais prevalentes em mulheres (57,89%). A faixa etária mais comprometida por PV foi entre 22 a 59 anos (81,82%), enquanto por PF maiores de 60 anos (62,5%). A principal área afetada nos casos de PV foi de membros superiores (20,69%), e de PF a face (21,43%). A prednisona foi o tratamento mais utilizado (42,87%). Observou-se que os dados epidemiológicos referentes a essa patologia ainda são escarços, especialmente na rgião norte do Brasil. Ainda não há consenso referente ao tratamento, e a escolha de medicações deve ser baseada nas particularidades de cada caso.
First case report of neck malignant triton tumor coexisting with NF1 and FANCD2 gene mutations
Authors: Chen Guangtang , Li Ming , He Qiujing
Published: June 2021

This clinical case first time reports a coexistence of FANCD2 and NF1
mutations in malignant triton tumor (MTT) patient and as the initial
operation, the complete resection has crucial influences on the
prognosis and recurrence of MTT.
Problem właściwego przyjmowania obciążenia zastępczego w dachu z imperfekcjami
Authors: Grzegorz Gremza  , Jan Zamorowski
Published: June 2021

Przeanalizowano siły wewnętrzne i naprężenia oraz oceniono wykorzystanie nośności obliczeniowej w wybranychelementach konstrukcji dachu z lokalnymi i globalnymi imperfekcjami geometrycznymi. Wartości tych imperfekcji przyjęto na podstawie informacji podanych w normach EN 1090-2 i EN 1993-1-1. Oprócz podstawowego modelu odniesienia z imperfekcjami przeanalizowano modele bez imperfekcji z różnorodnymi układami obciążeń zastępczych według koncepcji własnej autorów oraz porównawczo według normy EN 1993-1-1. Obliczenia wykonano, wykorzystując analizę I i II rzędu. Przedstawiono wnioski dotyczącedokładności oszacowania sił wewnętrznych oraz sprawdzenia stanów granicznych nośności i użytkowania przy układzie obciążeń zastępczych zaproponowanym w normie EN 1993-1-1. Wykazano niedoskonałość przepisów tej normy w zakresie przyjmowania obciążeń zastępczych w konstrukcjach dachowych z imperfekcjami, która prowadzi do niedoszacowania naprężeń w pasie dolnym wiązara.
Elementy główne badania miar rozpływu energii drgań w konstrukcjach
Authors: Katarzyna Jeleniewicz  , Mariusz Żółtowski
Published: June 2021

W pracy wskazano zakres możliwych zastosowań badania miar rozpływu energii drganiowej wykorzystywanych w modelowaniu procesów drganiowych i analizie modalnej w obszarze metodologii badań i metodyk szczegółowych nauk technicznych. Analizy teoretyczne i weryfikacja praktyczna badania wieluróżnych materiałów i budowli wskazują na szerokie możliwości zastosowań opisanych dokonań. Uznając potrzebę doskonalenia metod oceny stanu degradacji konstrukcji budowlanych, w pracy przedstawionouogólnione, istotne wyniki postępowania badawczego w zakresie weryfikacji skuteczności opracowanych metodyk szczegółowych zastosowania miar drganiowych w badaniach symulacyjnych, stanowiskowych i eksploatacyjnych.
Rozwój oprogramowania w kierunku parametrycznego modelowania obiektów budowlanych na potrzeby BIM
Authors: Joanna Pawłowicz  , Marlena A. Jurczak
Published: June 2021

Modele wizualizujące projektowany obiekt powstawały od zarania dziejów. Ich zadaniem było pokazanie inwestorowi wyglądu i rozwiązań zastosowanych w tworzonym budynku. Kiedyś odbywało się to przez budowanie makiet z różnych materiałów. Postęp technologiczny pozwolił jednak na tworzenie nowych narzędzi i metod wizualizacji. Programy komputerowe na początku zastępowały deski kreślarskie i wspomagały proces projektowania – CAD (ang. computer-aided design). Ułatwiały tworzenie zestawów linii i prostych płaszczyzn. Z biegiem czasu projektanci odczuli potrzebę kształtowania nie tylko prostych, ale też krzywoliniowych obiektów za pomocą komputerów, w czym pomocne było wykorzystanie parametryzacji. Parametry stanowiły zbiór zmiennych, które można było kształtować z zachowaniem różnych wzajemnych zależności. Z modelowania parametrycznego narodziła się technologia BIM (ang. building information modelling). Wirtualny obiekt mógł być kształtowany w cyfrowym środowisku, a także wzbogacany o różne informacje, dzięki czemu miał nie tylko geometrię i strukturę. Przypisane były do niego również inne dane pozwalające na identyfikację materiału czy technologii wykorzystanej do budowy. Sparametryzowane elementybudynku informują o ich ilości, koszcie zakupu czy właściwościach fizycznych. Dzięki parametrom w szybki i bezproblemowy sposób można nanieść poprawki. Zaawansowane technologie komputerowe umożliwiają projektantom różnych specjalności śledzenie tych zmian na bieżąco. Po ich zaakceptowaniu można łatwo wygenerować komplet dokumentacji budowlanej i korzystać z niej w postaci cyfrowej lub papierowej na budowie. Parametryzacja doprowadziła do powstawania obiektów, które kiedyś byłyby niemożliwe do zaprojektowania. Obecnie każdy projektant ma do czynienia z modelowaniem parametrycznym lub wkrótce na pewno się z tym zetknie.
Spatiotemporal analysis of some extreme rainfall indices over Iraq (1981–2017)
Authors: Al-Lami Alaa , Al-Shamarti Hasanain , Al-Timimi Yaseen
Published: June 2021

Extreme rainfall is one of the environmental hazards with disastrous effects on the human environment. Water resources management is very vulnerable to any changes in rainfall intensities. A spatiotemporal analysis is essential for study the impact of climate change and variability on extreme rainfall. In this study, daily rainfall data for 36 meteorological stations in Iraq during 1981–2017 were used to investigate the spatiotemporal pattern of 10 extreme rainfall indices using RClimDex package. These indices were classified into two categories: rainfall total (PRCPTOT, SDII, R95p, R99p, RX1day, and RX5day) and rainfall days (CDD, CWD, R10, and R20). Depending on the mean annual precipitation data, the study area was divided into three climatic zones to examine the time series features of those 10 indices. Results showed a tendency to increase in precipitation toward the northwestern part of Iraq, and more than 70% of stations achieved a positive trend for most indices. The most frequent negative trend appeared in eight stations distributed in the western and southern parts of Iraq, namely (Heet, Haditha, Anah, Rutba, Qaim, Nukheb, Najaf, and Fao). A significant positive trend appeared obviously in PRCPTOT and R95p with a rate of 0.1–4.6 and 0.5–2.7 mm per year, respectively. Additionally, the least trend increasing appeared in all precipitation days indices specifically in R10 and R20. Time series analyses revealed a positive trend in all regions under study, except SDII in the southern region. The most significant rate of change was noticed in regions one and two (northern and middle parts of Iraq), particularly for PRCPTOT and R95p 3.26 and 2.45 mm per day, respectively. Only the northern and eastern regions of Iraq experienced a high probability of significant extreme rainfall.
The absence of sexual difference in the theology of Maximus the Confessor
Authors: Brown Dewhurst Emma
Published: June 2021

There has been much attention devoted in the last decade and especially in
the last few years to Maximus the Confessor?s beliefs concerning sexual
difference and its removal. The most important text on this topic is
Ambiguum 41. There has been mixed reception of this text, with some scholars
advocating that Maximus believes that sexual difference was absent from
original human nature and will return to such a state in the eschaton; and
other scholars believing that this should be read as a metaphorical absence.
This article re-evaluates the text in question and argues that the former
position should be maintained. It goes some way to bring together current
scholarship on the text and to answers questions that arise from the
opposing reading.
The moral status of animals: Degrees of moral status and the interest-based approach
Authors: Todorovic Zorana
Published: June 2021

This paper addresses the issue of the moral status of non-human animals, or
the question whether sentient animals are morally considerable. The
arguments for and against the moral status of animals are discussed, above
all the argument from marginal cases. It is argued that sentient animals
have moral status based on their having interests in their experiential
well-being, but that there are degrees of moral status. Two interest-based
approaches are presented and discussed: DeGrazia?s view that sentient
animals have interests in continuing to live, and that their interests
should be granted moral weight; and McMahan?s TRIA which similarly
postulates that animals have interests and that in a given situation we
should compare the human and animal interests at stake. Finally, the paper
concludes that the anthropocentric approach to animal ethics should be
abandoned in favour of the biocentric ethics.
Circulating Thrombospondin-2 as a Novel Fibrosis Biomarker of Nonalcoholic Fatty Liver Disease in Type 2 Diabetes
Authors: Lee Chi-Ho , Seto Wai-Kay , Lui David Tak-Wai , Fong Carol Ho-Yi , Wan Helen Yilin , Cheung Chole Yu-Yan , Chow Wing-Sun , Woo Yu-Cho , Yuen Man-Fung , Xu Aimin , Lam Karen Siu-Ling
Published: June 2021

Objective

Preclinical studies suggested thrombospondin-2 (TSP2) to be
implicated in liver fibrosis. However, the clinical relevance of TSP2 in
non-alcoholic fatty liver disease (NAFLD) remains undefined. Here, we
investigated the cross-sectional and longitudinal associations of
circulating TSP2 levels with advanced fibrosis (≥F3 fibrosis) in NAFLD.

Research Design & Methods

Serum TSP2 levels were measured in 820 patients comorbid with type 2
diabetes and NAFLD. All participants received vibration controlled
transient elastography (VCTE) at baseline to evaluate their hepatic
steatosis and fibrosis using controlled attenuation parameter (CAP) and
liver stiffness (LS) measurements, respectively. Among those without
advanced fibrosis at baseline, reassessment VCTE was performed to
determine if ≥F3 fibrosis had developed over time. Multivariable
logistic regression analysis was used to evaluate the cross-sectional
and longitudinal associations of serum TSP2 level with ≥F3 fibrosis.

Results

Baseline serum TSP2 level was independently associated with the
presence of ≥F3 fibrosis (OR 5.13, p<0.001). The inclusion of serum
TSP2 level significantly improved the identification of ≥F3 fibrosis by
clinical risk factors. Over a median follow-up of 1.5 years, 8.8%
developed ≥F3 fibrosis. Baseline serum TSP2 level was significantly
associated with incident ≥F3 fibrosis (OR 2.82, p=0.005), independent of
other significant clinical risk factors of fibrosis progression
including body mass index, platelet count and CAP at baseline.

Conclusion

Circulating TSP2 level was associated with both the presence and
development of advanced fibrosis, and might be a potentially useful
prognostic biomarker for the development and progression of liver
fibrosis in NAFLD patients with type 2 diabetes.
Insulin Directly Regulates the Circadian Clock in Adipose Tissue
Authors: Tuvia Neta , Pivovarova-Ramich Olga , Murahovschi Veronica , Lück Sarah , Grudziecki Astrid , Ost Anne-Catrin , Kruse Michael , Nikiforova Victoria J. , Osterhoff Martin , Gottmann Pascal , Gögebakan Özlem , Sticht Carsten , Gretz Norbert , Schupp Michael , Schürmann Annette , Rudovich Natalia , Pfeiffer Andreas F.H. , Kramer Achim
Published: June 2021

Adipose tissue (AT) is a key metabolic organ which functions
are rhythmically regulated by an endogenous circadian clock. Feeding is a zeitgeber aligning the clock in AT with
the external time but mechanisms of this regulation remain largely unclear. We tested the hypothesis that postprandial
changes of the hormone insulin directly entrain circadian clocks in AT and
investigated transcriptional-dependent mechanism of this regulation. We
analysed gene expression in subcutaneous AT (SAT) of
obese subjects collected before and after the hyperinsulinemic-euglycemic clamp
(EC) or control saline infusion (SC). The expression
of core clock gene PER2,
PER3 and NR1D1 in SAT
were differentially changed upon insulin and saline infusion suggesting insulin-dependent clock regulation.
In human stem cell-derived adipocytes, mouse 3T3-L1 cells and AT explants from mPer2Luc knockin
mice, insulin induced a transient
increase of the Per2 mRNA and protein expression leading to the phase shift of
circadian oscillations and showing similar effects for Per1. Insulin
effects were dependent on the region between
the -64 and -43 in the Per2 promoter, but not on CRE and E-box elements. Our results demonstrate that
insulin directly regulates circadian clocks in AT and isolated adipocytes and thus represent a primary mechanism of
feeding-induced AT clock entrainment.
STAT3 Regulates Mitochondrial Gene Expression in Pancreatic β-Cells and its Deficiency Induces Glucose Intolerance in Obesity
Authors: Schaschkow Anaïs , Pang Lokman , Vandenbempt Valerie , Elvira Bernat , Litwak Sara A. , Vekeriotaite Beata , Maillard Elisa , Vermeersch Marjorie , Paula Flavia MM , Pinget Michel , Perez-Morga David , Gough Daniel J. , Gurzov Esteban N.
Published: June 2021

Most obese and insulin-resistant individuals do
not develop diabetes. This is the
result of the capacity of β-cells to adapt
and produce enough insulin to cover the needs of the organism. The underlying mechanism of β-cell adaptation in obesity, however, remains
unclear. Previous studies have suggested a role for STAT3 in
mediating β-cell development and human glucose homeostasis, but little is known
about STAT3 in β-cells in obesity. We observed enhanced cytoplasmic expression
of STAT3 in severely obese and diabetic subjects. To
address the functional role of STAT3 in adult β-cells,
we generated mice with tamoxifen-inducible partial or full deletion of STAT3 in
β-cells and fed them a high-fat diet before analysis. Interestingly, β-cell
heterozygous and homozygous STAT3-deficient mice showed glucose
intolerance when fed a high-fat diet. Gene expression analysis by RNA-Seq
showed reduced expression of mitochondrial genes in STAT3 knocked down human
EndoC-βH1 cells and was
confirmed
in FACS-purified β-cells from obese STAT3-deficient mice. Moreover, silencing of
STAT3 impaired mitochondria activity in EndoC-βH1 cells and human islets,
suggesting a mechanism for STAT3-modulated β-cell function. We propose STAT3 as a regulator of β-cell
function, improving glucose-induced insulin
secretion in obesity.
A multidisciplinary approach to optimizing long-term functional prognosis of a girl with quadriceps fibrosis
Authors: Luthringer Jessica , Garetier Marc , Lempereur Mathieu , Houx Laetitia , Burdin Valérie , Ropars Juliette , Ben Salem Douraied , Printemps Camille , Brochard Sylvain , Pons Christelle
Published: June 2021

The consequences and optimal treatment of quadriceps fibrosis following intramuscular quinine injection during childhood remain unclear. We report here a case of a 17-year-old girl who experienced unilateral quadriceps fibrosis following intramuscular injection of quinine as a baby. This case report describes the evolution of the condition during the child's growth, the long-term impact of early fibrosis on range of motion, muscle volumes, strength, gait, and activities of daily living. Rehabilitation involved orthoses and physiotherapy from the age of 6 years, when her knee flexion was reduced to 90?. A Judet quadricepsplasty was performed at 12 years because of continued loss of knee range with consequences for gait. At 16 years, knee range was satisfactory and gait variables were normalized. Functional evaluations and quality of life scales showed excellent recovery. Isometric strength of the involved quadriceps remained lower than the expected age-matched strength. Magnetic resonance imaging identified amyotrophy of the quadriceps, specifically the vastus intermedius. Despite being a focal impairment, quadriceps fibrosis had wider consequences within the involved limb, the uninvolved limb and functioning. This case report illustrates how children with quadriceps fibrosis can have a good prognosis, with excellent functional results at the end of the growth period, following early and appropriate management.
SURFO Technical Report No. 99-4
Authors:   SURFO
Published: June 2021

The 2000 technical reports written by undergraduate students participating in the SURFO (Summer Undergraduate Research Fellowships in Oceanography) Program while at the University of Rhode Island.
Improving Occupational Safety of the Metallurgical Enterprises Workers by the Methods of Monitoring the Psychophysiological Parameters of an Employee in Real Time
Authors:   Donbas State Technical Institute, Vishnevskiy D.A. , Zhiltsov A.P. ,   Lipetsk State Technical University, Bocharov A.V. ,   Lipetsk State Technical University, Sotnikov A.L. ,   Donetsk National Technical University
Published: June 2021

Presented are the developments using methods of monitoring the psychophysiological state of a person that are designed to improve the work safety of the employees at the metallurgical enterprises. A wearable device was developed for taking readings of the psychophysiological reactions (pulse, galvanic skin response, body and environmental temperature, etc.), and for determining the location of an employee within the production area in real time. The device can also record a sharp change in the position of a person in space, which indirectly indicates an emergency. The device indicates and reads changes throughout the shift and transfers to the server; when one of the monitored parameters increases, a message is generated on the operator monitor about a problem in the employee condition and his location. Previously developed program «System for monitoring the psychophysiological state of an operator at the metallurgical industry» with the help of a software processes the information from the device and warns the operator about the occurred hazard, and, also, suggests the ways for solving the problem. However, the decision itself remains with the operator. Under the conditions of working process modeling using the given parameters, the situations (accidents, personnel selection) were simulated that were close to real ones, which allowed to conduct a comparative analysis of the maximum and minimum permissible characteristics of the psychophysiological reactions for the employees of the metallurgical production. The developed device and monitoring system can significantly reduce (or completely prevent) the number of errors and accidents at the production site that are provoked by the influence of the human factor.
The Psycho-Sociological Perspective on Civilization: Insights from Malik Bennabi Theory
Authors: SHEHAB EL-MEKDAD , SMATI ABDELKOUDDOUS
Published: June 2021

Throughout history, civilizations have served as the highest level of human progress, and just like countries, empires or societies, they have always been prone to rise and fall. As a result, attempts to understand their dynamics, formation, and decline have been significantly important for sociologists, politicians, anthropologists and historians, both recently and in the past. One of those was the Islamic scholar Abdurrahman Ibn Khaldun, who tried in his book "Muqaddimah" to explain the rise and fall of states, and despite the uniqueness and distinction of his proposition, Ibn Khaldun's contributions confined to the temporal-spatial context that Ibn Khaldun tried to explore, and his theory has not been developed to explain the civilizational dynamics, especially the Islamic civilization. This matter has been noticed by Malik Bennabi, who succeeded in making remarkably systematic contributions to the topic. Through relying on the psycho-sociological essence of Ibn Khaldun's theory. So that, this paper attempts to present some insights from psycho-sociological approach of Malik Bennabi in explaining the rise and fall of civilizations, compared to some Western theories that have addressed the relative topics.
Contribution of Sufism to the Development of Moderate Islam in Nusantara
Authors: Anshori M. Afif , Prasojo Zaenuddin Hudi , Muhtifah Lailial
Published: June 2021

This article analyzes the relationship between Sufism (mystical Islam) and the making of moderate Islam in Nusantara, a region that historically has been covered by various Muslim-majority populations in Southeast Asia, especially Indonesia. This focus is important for two reasons. First, Islam was first introduced to this region through the hands of Sufi preachers when Sufism was the the-dominant feature of Islam. Second, Islam has been practiced peacefully in this region for centuries through an adaptation with mystical practices of the local beliefs. Thus, the main question of this article is aimed at exploring the ways in which Sufism has contributed to the development of moderate Islam in Nusantara. In doing so, two different approaches are employed: the orthopraxic and historical approach and the phenomenological approach. While the former is especially employed to examine the historical introduction of Sufism into Nusantara, the latter is to analyze the essential teachings of Sufism, which are deemed flexible and inclusive towards cultural diversity. This study concludes that the development of moderate Islam in Nusantara cannot be separated from the century-long contribution of Sufism, the implication of which has created fundamental structures for harmonization of religious lives in Nusantara.
Content Factor to Promote Islamic Weblog Continuance Uses
Authors: SHAHIBI MOHD SAZILI , MASREK MUHAMMAD NORMAN , IBRAHIM NURUL HAFIZ
Published: June 2021

Religious information is now being disseminated through various internet applications including weblogs. Providing digital Islamic Information content online via the internet is vulnerable. Its exposure to the modification of information was taken from the original information resources by irresponsible parties. This research paper is about examining the information content and relationship of each factor that encourages the peoples to continue to use the Islamic weblogs and able to recognize between the true and false on Islamic information teaching. Quantitative research method was applied for data collection and about 800 questionnaires have been distributed to Islamic religious subject teachers. Finding of the study revealed significant value for content factors such as Continuance Use, Satisfaction, Perceived Usefulness that promote continued use of Islamic web blog. Hypotheses analysis of the finding indicated only content factors like Reliability and Confirmation, Perceived Usefulness and Satisfaction, Confirmation and Satisfaction, Continuance Use and Satisfaction have supported each other for prediction continuances use of Islamic web blog.
Muhammadiyah Identity and Muslim Public Good: Muslim Practices in Java
Authors: QODIR ZULY , JUBBA HASSE , MUTIARIN DYAH , HIDAYATI MEGA
Published: June 2021

The study in the current article intends to explore the conception of the presence of the Islamic religious movement known as Muhammadiyah, which still remains to this day in relation to the life of the Muslim community, including its socio-religious, cultural, economic, and political aspects. Accordingly, a proper understanding of Muhammadiyah is not only achieved through a religious approach, but also by examining social-historical conditions, which is by demonstrating the extent that its presence in conducting religious activities correlates with the true concept of Islam (Muslim Public Good). The current study aims to observe the models and strategies utilized by Muhammadiyah’s champions in repositioning and reflecting on religious movements, which have been framed at both conceptual and practical level. Subsequently, the framing strategies were used as a social capital to carry out their religious activities. For issues that are practical in nature, the study in this article is a description and elaboration about the aspirations, perceptions, intentions, ideas, goals, and thoughts pertaining to a social system inspired by the spirit of religiosity in Indonesia, in general, and Islam in Java, in particular, within the Muhammadiyah tradition as a Muslim public good (the true Islam).
Community Clinic in Bangladesh: Empowering women through utilization and participation
Authors: Riaz Baizid Khoorshid , Ahmad Sk Akhtar , Islam Md Ziaul , Ali Liaquat
Published: June 2021

Background: Community Clinics (CC) has been established to provide basic healthcare services at the doorstep of the community people in Bangladesh. Besides health care, government has taken a development program through CC to improve maternal health care with an aim to reduce the maternal mortality. This study was an attempt to find out the role of community women in the utilization and participation of CC management.
Methods: This cross-sectional study was carried out in 32 randomly selected CCs from 16 randomly selected districts. A total of 63 service providers, 2238 service users (patients) and 3285 community members were included as the respondents of this study. For data collection respondents were interviewed face to face by using a pretested questionnaire.
Results: The majority of the service providers of the CC were from the local community, and a higher proportion of them were female (52.4%). The providers provided healthcare services both in CC and at community level. A total of 2238 patients visited the 32 studied CCs per day for getting treatment and significantly a higher proportion of them were female (71.2%). Most of the patients (83.0%) expressed satisfaction with the services provided in the CCs and most of them were female (83.8%). Of the total 3285 respondents, 60.3% were the women from the catchment communities. The activities of the CC were known by all of them (98.3%) and they participated in the management of CC.
Conclusions: The study revealed that because of utilization and participation in the management of CC, the women became an imperative person in the community, thus empowering them in healthcare development.
Relationship Quality in Geriatric Healthcare Delivery: A sustainable model
Authors: Joseph Sindhu
Published: June 2021

Objective: This study is undertaken to examine geriatric relationship quality in healthcare delivery in Kerala. Drawing the hypothetical relationship, a model for elderly geriatric healthcare delivery to be developed.

 Methods:  A Structural Equation Modelling technique, based on a positivist approach, was employed to analyse the association between relationship quality and geriatric healthcare delivery. The data was collected from 405 elderly people in Kerala between June 2020 and November 2020.

 Results: A consistent empirical model of predictive relationships between the hypothesized variables was found, and a geriatric relationship quality healthcare model was developed.  Service quality has emerged as a significant determinant of relationship quality. Even though patient centricity is not hypothetically related to relationship quality, it is a significant determinant of service quality.

 Conclusion: Geriatric healthcare management must consider relationship quality as a prominent factor while evaluating the quality of healthcare delivery as it is the outcome of all the structural and procedural aspects.
Providing A Technical Solution to Improve Nurses' Performance in Drug Delivery : A qualitative study
Authors: Kiani Fatemeh , Shahsavani Alireza , Barahoui Zeinab
Published: June 2021

Background and Purpose: Providing services in the nursing profession is very wide. In the field of clinical services, one of the most important is to provide care related to medication, which in fact is one of the ways to assess the quality of nursing care, so this study aims to provide a solution. Technical measures were taken to improve the performance of nurses in the drug delivery process in hospitals affiliated to Zahedan University of Medical Sciences in Iran
Materials and Methods: This study was conducted with a qualitative approach and contractual content analysis method in 2017-18. Participants were 16 nurses and a physician working in different wards of the hospital who were included in the study by purposive sampling. The method of data collection was semi-structured interviews. All interviews were conducted and reviewed and analyzed by contractual content analysis.
Results: In the present study, "steps to prevent drug error" as the main category and "acting professionally" and "providing technical solutions" as two subcategories were extracted from the data.
Conclusion: The results showed that the use of nurses 'experience and knowledge as technical solutions to prevent drug errors can play an important role in improving nurses' performance and increasing patient safety
ОКРЕМІ АСПЕКТИ РОЗВИТКУ ОСОБИСТОСТІ МОЛОДШИХ ШКОЛЯРІВ З ПОРУШЕННЯМИ СЛУХУ
Authors:   Кам’янець-Подільський національний університет імені Івана Огієнка, Дмітрієва Оксана
Published: June 2021

У статті представлено аналіз результатів дослідження окремих аспектів розвитку особистості молодших школярів із порушеннями слуху в умовах сучасного закладу загальної середньої освіти для дітей із порушеннями слуху. З’ясовано особливості процесу формування самооцінки молодших школярів з порушеннями слуху; представлено результати вивчення педагогічної документації, опитування педагогів, анкетування батьків, спостережень за учнями. Визначено вплив особливостей комунікації учнів із порушеннями слуху та взаємодії з педагогами і батьками на розвиток особистості школярів.
THE FEMININE PARADIGM OF CULTURE IN ALICE VOINESCU’S CONCEPTION
Authors: WÄCHTER Magda
Published: June 2021

The Feminine Paradigm of Culture in Alice Voinescu’s Conception. Alice Voinescu, the first Romanian woman to obtain a PhD in Philosophy, proposed a female cultural paradigm in the conferences she held between 1933-1943, in the context of the women’s emancipation movement of the interwar period. In her view, the male model of knowledge, based on abstract thinking, must be permanently conjoined with the female one, based on intuition and affect, in a totalizing, modern perspective. The salvation of the “eternal human” through the “eternal feminine”, characterized by respect for tradition and continuity both in culture and in society, represents an alternative for materialistic civilization, which is the outcome of the male cognitive pattern.
REZUMAT. Paradigma feminină a culturii în concepția lui Alice Voinescu. Alice Voinescu, prima femeie doctor în Filosofie din România, propune în conferințele susținute între anii 1933-1943 o paradigmă culturală de tip feminin, în contextul mișcării de emancipare a femeilor din perioada interbelică. În viziunea sa, modelul masculin al cunoașterii, bazat pe gândirea abstractă, trebuie conjugat permanent cu cel feminin, întemeiat pe intuiție și afect, într-o perspectivă totalizatoare modernă. Salvarea “eternului uman” prin “eternul feminin”, reprezentat deopotrivă în cultură și în societate de respectul pentru tradiție și continuitate, reprezintă alternativa unei civilizații materialiste, operă a tiparului cognitiv masculin.
Cuvinte-cheie: Alice Voinescu, feminitate, feminism, spiritualitate, masculin, cultură, generație, om nou
PENENTU KEUNGGULAN BERSAING PADA UMKM : APAKAH KOMPETENSI DIGITAL DAN ORIENTASI KEWIRAUSAHAAN PENTING ?
Authors: Sari Sofi Maya , Yunizar Yunizar , Sartika Dina
Published: June 2021

One of the efforts to improve the competitive advantage in rapid technological developments, especially in Micro, Small and Medium Enterprises (MSMEs), is to maximize the potential of human resources. However, at this time human resources MSMEs’owners are not acceptable in digital competence and low ability to improve entrepreneurial orientation. The role of human resources consisting of digital competence and entrepreneurial orientation leads to the competitive advantages of micro, small and medium enterprises. The study used a quantitative approach, using multiple regression analyses to analyze a questionnaire sample of 180 micros, small, and medium enterprises manufacture of food products in Bandung City. Results showed digital competence and entrepreneurial orientation have positive effect on competitive advantage. Salah satu usaha untuk dapat meningkatkan keunggulan bersaing ditengah perkembangan teknologi yang pesat khususnya pada Usaha Mikro, Kecil, dan Menengah (UMKM) adalah dengan memaksimalkan potensi dari sumber daya manusia yang dimilikinya. Namun begitu saat ini sumber daya manusia atau pelaku usaha mikro, kecil dan menengah kurang akseptabel dalam penguasaan kompetensi digital serta rendahnya kemampuan dalam meningkatkan sikap orientasi kewirausahaannya. Peranan sumber daya manusia yang terdiri dari kompetensi digital dan orientasi kewirausahaan ini mengarah kepada keunggulan bersaing usaha mikro, kecil, dan menengah. Penelitian ini menggunakan pendekatan kuantitatif, dengan menggunakan analisis regresi berganda untuk menganalisis sampel kuisioner sebanyak 180 pelaku UMKM industri pengolahan makanan di Kota Bandung. Hasil penelitian mengungkapkan bahwa kompetensi digital dan orientasi kewirausahaan berpengaruh positif terhadap keunggulan bersaing.
ANALISIS RETURN SAHAM DENGAN PENDEKATAN MONDAY EFFECT DAN WEEKEND EFFECT DI BURSA EFEK INDONESIA
Authors: Alexandri Mohammad Benny , Dai Ratna Meisa , Fauziyah Ema
Published: June 2021

This study discusses the analysis of stock returns using the Monday effect and Weekend effect  on the Indonesia Stock Exchange in the LQ45 period February 2017 - January 2018. The method  of analysis technique used  is the partial test with SPSS software ver.21 . The results of this study indicate that there is an effect of the Monday effect and Weekend effect on the LQ45 daily stock return on the Indonesia Stock Exchange, where the lowest return occurs on Monday (Monday effect) and the highest return on Friday (weekend effect), in addition there is the lowest return concentrated in the last two weeks of each month (fourth and fifth week) or also called week four effect.  Penelitian ini membahas tentang analisis return saham dengan menggunakan pendekatan Monday effect dan Weekend effect di Bursa Efek Indonesia pada LQ45 periode Februari 2017 - Januari 2018. Teknik analisis data yang digunakan menggunakan uji parsial dengan software SPSS ver.21. Hasil penelitian ini menunjukkan bahwa terdapat pengaruh Monday effect dan Weekend effect terhadap return saham harian LQ45 di Bursa Efek Inonesia, di mana return terendah terjadi pada hari Senin (Monday effect) dan return tertinggi pada hari Jumat (weekend effect), selain itu terdapat return yang terendah terkonsentrasi pada dua minggu terakhir setiap bulannya (minggu keempat dan kelima) atau disebut juga week four effect.
ANALISIS PENGUNAAN WHATSAPP BUSINESS UNTUK MENINGKATKAN PERJUALAN DAN KEDEKATAN DENGAN PELANGGAN DI PT SAUNG ANGKLUNG UDJO
Authors: Hendriyani Chandra , Dwianti Selvia Putri , Herawaty Tetty , Ruslan Budiana
Published: June 2021

The use of communication platforms is beneficial for companies, one of which is the use of mobile-based applications, namely the WhatsApp Business application, to meet market demands that require easy access to information directly and quickly. The purpose of this study was to determine the increase in sales at PT Saung Angklung Ujdo after using WhatsApp Business in the implementation of the sales process. The research method used is a qualitative method with a descriptive approach. Data collection techniques are carried out by observation, interviews with the Digital Strategy Manager, and literature study of books, journals, and documents related to research discussions. The results show that there is a match between theory and practice in the sales process with the use of the WhatsApp Business application and an increase in sales after the use of the WhatsApp Business application by PT Saung Angklung Udjo.  Penggunaan platform komunikasi sangat membantu perusahaan salah satunya adalah penggunaan aplikasi berbasis mobile yaitu aplikasi WhatsApp Business untuk memenuhi tuntutan pasar yang membutuhkan kemudahan akses informasi secara langsung dan cepat. Tujuan dari penelitian ini adalah untuk mengetahui peningkatan penjualan pada PT Saung Angklung Ujdo setelah menggunakan WhatsApp Business dalam pelaksanaan proses penjualannya. Metode penelitian yang digunakan adalah metode kualitatif dengan pendekatan deskriptif. Teknik pengumpulan data dilakukan dengan observasi, wawancara dengan Manajer Strategi Digital, dan studi pustaka terhadap buku, jurnal, dan dokumen yang berkaitan dengan pembahasan penelitian. Hasil penelitian menunjukkan bahwa terdapat kesesuaian antara teori dan praktek dalam proses penjualan dengan penggunaan aplikasi WhatsApp Business dan peningkatan penjualan setelah penggunaan aplikasi WhatsApp Business yang dilakukan oleh PT Saung Angklung Udjo.
WORK ENGAGEMENT KARYAWAN GENERASI MILENIAL PADA PT. X BANDUNG
Authors: Sukoco Iwan , Fu’adah Dian Nur , Muttaqin Zaenal
Published: June 2021

This article aims to determine the description and level of work engagement of millennial generation employees at PT X. The method used is a quantitative method with a descriptive approach. The study population was all employees of the millennial generation of PT. X total 132 employees. The sampling technique used the Slovin formula with a total of 57 people. Collecting data in the form of a work engagement questionnaire with dimensions of vigor, dedication and absorption, interviews, and observation. The results obtained in this study are employees of the millennial generation of PT. X majority has high level of work engagement, meaning that most employees experience a positive state of mind regarding their work. This is shown when the millennial generation employees of PT. X   able to stay focused and concentrated on work even though the work is tough, feels that what he is doing is a noble job, and enjoys a very intense job (full of concentration).  Artikel ini bertujuan untuk mengetahui gambaran dan tingkat work engagement karyawan generasi milenial di PT X. Metode yang digunakan adalah metode kuantitatif dengan pendekatan deskriptif. Populasi penelitian adalah seluruh karyawan generasi milenial PT. X yang berjumlah 132 karyawan. Teknik pengambilan sampel menggunakan rumus slovin dengan jumlah 57 orang. Pengumpulan data berupa kuesioner work engagement dengan dimensi vigor, dedication dan absorption, wawancara, dan observasi. Hasil yang diperoleh dalam penelitian ini adalah karyawan generasi milenial PT. X mayoritas memiliki work engagement pada tingkat tinggi, artinya sebagian besar karyawan mengalami keadaan pikiran positif terkait pekerjaannya. Hal ini ditunjukkan ketika bekerja karyawan generasi milenial PT. X mampu tetap fokus dan konsentrasi terhadap pekerjaan walaupun pekerjaan tersebut berat, merasa apa yang dikerjakan merupakan pekerjaan mulia, dan menikmati pekerjaan yang sangat intens (penuh konsentrasi).
PENGEMBANGAN BISNIS PADA STARTUP TEMANRINDU DENGAN METODE STARTUP EVOLUTION CURVE
Authors: Yudhistira Rasyid , Yuniaristanto Yuniaristanto , Hisjam Muhammad
Published: June 2021

Technological developments have made it easier for people to use social networks. Almost all people of productive age use the internet in their social interactions. The purpose of this research is primarily to provide a platform for TemanRindu to make its product prototype appropriately with the Lean Canvas business model and so  Startup Evolution Curve as its method. The main principles of Startup Evolution Curve are providing step-by-step guidance in company discussions,  business development of TemanRindu by Feasibility Study especially on market aspect so that shown the segment and position TemanRindu itself. Product prototyping or Minimum Viable Product (MVP) start from doing hypothesis verification that will be used on MVP adjustment. Slogan making and pipe and sales funnel are also be done that lately will be used to planning the marketing strategy.  This method has succeeded on generating of TemanRindu’s market segmentation and positioning as well as the making of product prototype in the form of Instagram design based on Lean Canvas design. Its affect on  increasing of business growth in followers, likes, comments and saves because the product has been more adapted to customer needs without reducing the added value that offered.Perkembangan teknologi menyebabkan semakin mudahnya masyarakat dalam menggunakan jejaring sosial. Hampir keseluruhan masyarakat usia produktif memakai internet dalam interaksi sosialnya. Tujuan dari penelitian ini adalah menyediakan sarana untuk startup TemanRindu dalam membuat prototipe produk bisnisnya dengan model bisnis Lean Canvas secara tepat dan dengan metode Startup Evolution Curve. Prinsip utama dari Startup Evolution Curve adalah memberikan arahan per tahap dalam diskusi perusahaan, dan pengembangan bisnis startup TemanRindu melalui Feasibility Study pada aspek pasar sehingga memberikan gambaran terhadap segmen dan posisi daripada TemanRindu. Pembuatan prototipe produk atau Minimum Viable Product (MVP) dilakukan dari verifikasi hipotesis yang akan digunakan pada penyesuaian MVP. Pembuatan slogan hingga uji komunikasi dan saluran distribusi juga dilakukan yang kemudian dapat digunakan untuk menentukan strategi pemasaran. Pengaplikasian metode tersebut berhasil menghasilkan pemetaan daripada segmentasi dan posisi TemanRindu di pasar dan juga terciptanya prototipe produk TemanRindu berupa desain kiriman Instagram yang berdasarkan atas rancangan Lean Canvas. Dampaknya pertumbuhan bisnis naik, baik pada followers, likes, comment maupun save karena produk telah lebih disesuaikan dengan kebutuhan pelanggan tanpa mengurangi nilai lebih yang ditawarkan TemanRindu.
STATE-OF-THE-ART DIGITAL ENTREPRENEURSHIP DALAM BISNIS KELUARGA: ANALISIS CO-AUTHORSHIP DAN CO-OCCURRENCE
Authors: Purnomo Margo , Maulina Erna , Zaki Ahmad , Fordian Dian
Published: June 2021

There are still few in family business studies that discuss the topic of digipreneurship, even though digipreneurship is important for continuity and growth of companies in today's business world. Therefore, the aim of this study is to uncover the state-of-the-art and create research gaps in the literature related to digipreneurship in family business. For this purpose, a bibliometric study using co-authorship and key word co-occurrence analysis conducted in the Scopus database. The results of the co-authorship analysis show that the cohesiveness of collaboration in exploring digipreneurship in family business has been achieved at the state level in the 2017-2020 period, but at the author and organizational level has not been achieved. This indicates that the study of digipreneurship in family business is in early stages of growth. The results of the co-occurrence keyword analysis show that there are three specific domains in the field, namely digital transformation of entrepreneurial-oriented family firms; entrepreneurial knowledge management and digital capabilities in the family business; and transgenerational entrepreneurship in the digital era; Another domain that is important to be developed but has not been identified and has become a research gap is the value chain and internal processes in digipreneurship in family business. Penelitian bisnis keluarga sampai saat ini belum banyak yang membahas topik digipreneurship, padahal digipreneurship penting untuk keberlangsungan dan pertumbuhan perusahaan di dunia bisnis saat ini. Karena itu, tujuan penelitian ini adalah untuk mengungkap state-of-the-art dan memunculkan kesenjangan penelitian dalam literatur terkait dengan digipreneurship dalam bisnis keluarga. Untuk tujuan tersebut, Penulis melakukan penelitian bibliometrik dengan metode analisis co-authorship dan analisis co-occurrence kata kunci pada basis data Scopus. Hasil analisis co-authorship menunjukkan bahwa kohesivitas kolaborasi dalam mengekplorasi digipreneurship dalam bisnis keluarga sudah tercapai di tingkat negara dalam rentang tahun 2017-2020, namun kohesivitas co-authorship di tingkat penulis dan organisasi belum tercapai. Kondisi demikian mengindikasikan bahwa kajian digipreneurship dalam bisnis keluarga masih berada dalam fase awal tumbuh. Hasil analisis co-occurrence kata kunci menunjukkan bahwa ada tiga domain yang khas dalam publikasi ilmiah digipreneurship dalam bisnis keluarga yaitu transformasi digital perusahaan keluarga berorientasi entrepreneurial, manajemen pengetahuan entrepreneurial dan kapabilitas digital dalam bisnis keluarga, dan entrepreneurship transgenerasi pada era digital; Domain lain yang penting untuk dikembangkan namun belum teridentifikasi dan menjadi kesenjangan dalam penelitian ini adalah domain rantai nilai dan proses internal pada digipreneurship dalam bisnis keluarga.
PENGARUH KOMITMEN AFEKTIF, KOMITMEN BERKELANJUTAN DAN KOMITMEN NORMATIF TERHADAP KINERJA PENGURUS KOPERASI DI KOTA SUKABUMI, JAWA BARAT
Authors: Muhyi Herwan Abdul
Published: June 2021

A cooperative is an economy-based organization that is owned and operated by a group of people for the common interest. However, over time, the conditions for the development of the cooperative declined. One of them is the condition of growth and development of cooperatives in the city of Sukabumi. This is what makes the author's basis for conducting research. The purpose of this study was to determine and analyze affective commitment, continuous commitment, normative commitment and the performance of cooperative management in Sukabumi City. The method used is a quantitative research method with explanatory research type. Data were analyzed using SMART PLS 3. The sample size was 42 respondents using the Random Sampling Technique. The data collection technique is done by distributing questionnaires, interviews, and documentaries. The results of this study indicate that affective commitment has a significant effect on performance, continuous commitment has a significant effect on performance, and normative commitment has a significant effect on performance. Furthermore, these three variables have a significant and simultaneous effect on the performance of cooperative management in Sukabumi City. The affective commitment variable is in the high category and has the highest average value achievement of 3.68. Koperasi merupakan sebuah organisasi berbasis ekonomi yang dimiliki dan dioperasikan oleh sekelompok orang demi kepentingan bersama. Namun seiring berjalannya waktu, kondisi perkembangan koperasi semakin menurun. Salah satunya kondisi pertumbuhan dan perkembangan koperasi yang ada di kota Sukabumi. Hal ini yang menjadikan dasar penulis untuk melakukan penelitian. Tujuan penelitian ini adalah untuk mengetahui dan menganalisis komitmen afektif, komitmen berkelanjutan, komitmen normatif dan kinerja pengurus koperasi di Kota Sukabumi. Metode yang digunakan yaitu metode penelitian kuantitaf dengan tipe explanatory research. Data dianalisis menggunakan SMART PLS 3. Ukuran sampel adalah 42 responden dengan Random Sampling Technique. Teknik pengumpulan data dilakukan dengan cara menyebarkan kuesioner, wawancara, dan dokumenter. Hasil penelitian ini menunjukkan bahwa komitmen afektif berpengaruh secara signifikan terhadap kinerja, komitmen berkelanjutan berpengaruh secara signifikan terhadap kinerja, dan komitmen normatif berpengaruh secara signifikan terhadap kinerja. Selanjutnya, ketiga variabel tersebut berpengaruh secara signfikan dan simultan terhadap kinerja pengurus koperasi di Kota Sukabumi. Adapun variabel komitmen afektif berada pada kategori tinggi serta memiliki pencapaian nilai rata-rata tertinggi yaitu sebesar 3,68.