bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring the relationship between mental distress and cognitive dissonance across transnational identities using BMF analytics
Authors: Jin Ruining , Le Tam-Tri , Nguyen Minh-Hoang , Vuong Quan-Hoang
Published: November 2022

The research used a hybrid approach to examine the mental distress among Chinese international students caused by cognitive dissonance due to double stigmatization during the COVID-19 pandemic. The research used the mindsponge mechanism to examine the information processes of their psychological distress and coping strategies in the wake of double stigmatization. In addition, we also ran a small-scale Bayesian analysis aided by Markov Chain Monte Carlo (MCMC) algorithms to provide preliminary quantitative evidence on the predictors of mental distress in the study’s context. Three rounds of interviews were conducted with 15 Chinese international students who studied in the United States and returned to China between 2018 and 2020, which culminated in 45 interviews through a longitudinal study to probe the transnational identities of this population before and during the double stigmatization. The study concluded that carrying out behaviors and displaying mental traits not aligned with the standards of current dominant collective values may increase mental distress. Navigators, who are more mentally flexible and view things unbiasedly, are less susceptible to misinformation/disinformation and less likely to suffer from intense mental distress than wayfarers and homestayers, who have relatively more radical mindsets. Navigators also have more coping strategies available when facing cognitive dissonance as compared to people in the other two identity clusters.
Penggunaan Aplikasi Dana Sebagai Media Dompet Digital dan Transaksi di Indonesia
Authors: Azindhani Zidan
Published: November 2022

Banyak faktor mempengaruhi minat menggunakan e-wallet pada aplikasi DANA, salah satunya adalah Kemudahan dan fitur layanan. Dari berbagai macan e-wallet payment yang ada, DANA adalah salah satu aplikasi pembayaran yang ada dan tumbuh cepat di Indonesia
KONSEP EKONOMI PADA MASA ROSULULLAH
Authors: Amanda Rini
Published: November 2022

Ada dua Bisnis yang dijalankan Muhammad sebelum diangkat menjadi Nabi. Pertama mengembala kambing ketika ia tinggal bersama ibu susuannya. Dan bisnis yang kedua berdagang ketika ia tinggal bersama pamannya Abu thalib. Ia berdagang mengikuti pamannya berdagang ke Negeri Syam sampai dia dewasa.
sistem kapitalisme
Authors: Nurhidayat
Published: November 2022

sistem kapitalis memandang bahwa manusia adalah pemilik satu-satunya terhadap harta yang telah diusahakan. tidak ada hak orang lain di dalmnya. ia memiliki hak mutlak untuk membelanjakan sesuai dengan keinginannnya.
Sex Differences in Costly Signaling in Rural Western China
Authors: Cairang Dongzhi , Ge Erhao , Du Juan , Mace Ruth
Published: November 2022

Costly rituals convey the commitment to communities and advertise trustworthiness and cooperativeness to peers, which might explain why humans perform costly religious rituals. Here, we compare the efficacy of occasional public displays versus regular but less public acts for prestige enhancement. We collected data on religious practices ranging from daily routine practices to infrequently elaborate distant pilgrimages among residents of an agricultural Tibetan village, as well as their reputational standings. We find that religious practices are mediated by demographic factors such as wealth, age and gender. Women are more inclined to daily religious activities, but men are more predisposed to distant pilgrimages. Distant pilgrimages increase the perception of all prosocial characteristics. In contrast, daily practices are positively associated with nominations of devoutness but not with other qualities. Devoutness sometimes negatively relates to other reputational qualities, limiting the interpretation of religiosity as only about signaling prosociality.
Resensi buku pembimbing kedalam perjanjian baru
Authors: surya Theo semarga
Published: November 2022

Buku: pembimbing ke dalam perjanjian baru ditulis oleh Drs.M.E.Duyverman ; editor: Yani M. Rengkung,Chrisostomus sihotang; korektor naskah : Borozatulo Gea; setter: Prio Yusrianto; Desain : Deisy Rikayanti; cetakan keduapuluhdua; Jakarta; penerbit : BPK Gunung mulia, tahun 2013;ix ; 267 halaman ; ketebalan buku 21 cm. Buku yang diberi judul pembimbing ke dalam perjanjian baru yang dituliskan oleh Drs.M.E.Duyverman, yang dimana isinya yang secara garis besar membahas tentang; yang pertama berbicara tentang tugas ilmu pembimbing, kedua; berisi tentang ilmu salina (Textual criticism ) dan ketiga berbicara tentang kitab-kitab didalam perjanjian baru dan kitab I korintus salah satunya yang ditulis dalam buku ini pada halaman 98; dan yang keempat berbicara tentang kanon dan sejarahnya. Buku ini sangat menarik untuk menjadi bahan bacaan baik bagi kalangan non akademisi teologi, secara khusus para pelaku ilmu teologi sendiri, dalam mempeluas pemahamannya tentang setiap kitab perjanjian baru yang ada dalam Alkitab.
Revisiting the issues of efficiency and effectiveness in using science funding following the case of the JAXA research data fabrication
Authors: Le Tam-Tri , Jin Ruining
Published: November 2022

We discuss the issues of effectiveness and efficiency in scientific activities, in light of the recent data fraud at Japan Aerospace Exploration Agency.
PENGANTAR PERJANJIAN BARU
Authors: Oktafia Liana
Published: November 2022

Tujuan dari meresensi buku ini adalah untuk memahami isi dari buku ini tentang surat Ibrani. Setelah membaca buku ini, ditamukan bahwa kitab Ibrani ini, tidak bisa dipastikan bahwa apakah kita ini sebuah surat atau homili. Penulis dari kitab Ibrani juga tidak diketahui secara pasti, meskipun banyak yang menduga bahwa Pauluslah yang menjadi penulis kitab ini. Banyak hal yang sebenarnya dipertanyakan dari Ibrani ini. Selain dari siapa penulis dan apakah ini surat, masalah lain juga yang dipertanyakan adalah kepada siapa Ibrani ini sebenarnya ditulis. Banyak hal yang dipertanyakan tentang Ibrani ini dan buku ini hanya memberikan sedikit gambaran tentang pertanyaan-pertanyaan yang ada, karena memang tidak ada jawaban pasti yang ditemukan.
Differential expression of ZNF414 in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: November 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines sporadic ALS using published data (3, 4). We found significant differential expression of ZNF414, encoding zinc finger protein 414, in iPSC-derived motor neurons of patients with ALS. ZNF414 was also differentially expressed in primary lower motor neurons isolated from patients with ALS. ZNF414 transcript was present at significantly lower levels in ALS iPSC-derived motor neurons. These analyses will begin to define the transcriptional landscape of ALS.
HUKUM PIDANA PERUNDUNGAN PADA ANAK
Authors: Firdaus Vestin Aulia
Published: November 2022

Perundingan adalah tindakan yang dilakukan secara sengaja untuk menyakiti secara fisik, verbal, psikologis oleh seseorang atau kelompok orang terhadap seseorang/kelompok orang yang merasa tidak berdaya. Anak yang menjadi korban perundungan harus mendapatkan perlindungan hukum. Perlindungan anak sebagai segala kegiatan untuk menjamin dan melindungi anak dan hak-haknya agar dapat hidup, tumbuh, berkembang, dan berpatisipasi secara optimal sesuai dengan harkat dan martabat kemanusiaan, serta mendapatkan perlindungan dari kekerasan dan diskriminasi. Permasalahan terbesar dari anak yang berhadapan dengan hukum adalah karena UU No. 3 Tahun 1997 tentang Pengadilan Anak sudah tidak relevan lagi, baik dari aspek yuridis, filosofis, dan sosiologis. Undang-undang ini tidak memberikan solusi yang tepat bagi penanganan anak sebagai anak yang berhadapan dengan hukum. Anak yang berkonflik dengan hukum yang diselesaikan dipengadilan, berakibat timbulnya tekanan mental dan psikologis terhadap anak yang berkonflik dengan hukum tersebut sehingga menggangu tumbuh kembang anak. Dengan demikian perlu adanya kebijakan hukum pidana dalam penanganan tindak pidanan perundungan, terutama terhadap anak. Selain itu, pemerintah, orang tua, wali, masyarakat, dan pihak sekolah memiliki kewajiban untuk memberikan pendidikan karakter dan menanamkan nilai-nilai kemanusiaan dan hak asasi pada anak untuk mencegah terjadinya perundungan.
KERANGKA KERJA KEBIJAKAN MONETER ISLAM
Authors: Taha Muh. Ridwan
Published: November 2022

Sasaran sistem moneter dapat dilihat dari sasaran atau tujuan kebijakan moneter, pada dasarnya intervensi pemerintah dalam kegiatan ekonomi dari segi kebijakan, dapat dibedakan ke dalam dua bentuk kebijakan utama, yakni kebijakan moneter dan fiskal.
PANCASILA, KEADILAN SOSIAL, DAN PERSATUAN INDONESIA
Authors: Fauzi Ahmad Zulfikar Al
Published: November 2022

Maraknya separatisme yang mengemuka bersama munculnya kelompok separatis dengan segudang cita-cita idealistik-komunal untuk menciptakan kehidupan yang lebih demokratis dan lebih berkeadilan akhir- akhir ini terasa cukup memprihatinkan. Hal ini terjadi di tengah-tengah upaya berbagai pihak—baik pemerintah dan non-pemerintah—untuk mempertahankan kesatuan dan persatuan Indonesia. Haruskah masalah ini diselesaikan dengan konflik horizontal dan opsi perpisahan (disintegrasi). Bukankah konflik tidak dapat dan tidak akan pernah dapat menjadi satu solusi penyelesaian masalah yang terbaik. Artikel dibuat sebagai respons terhadap masalah kebangsaan yang terkait, dengan harapan dapat menjadi salah satu solusi alternatif bagi upaya pemecahan persoalan yang ada.Kata kunci: Pancasila, keadilan sosial, persatuan Indonesia
PRAKTIK KEBIJAKAN MONETER ISLAM
Authors: Halim Ismail
Published: November 2022

Resume singkat terkait materi praktik kebijakan moneter islam.
Comparing resting state and task-based EEG using machine learning to predict vulnerability to depression
Authors: Kaushik Pallavi , Yang Hang , Roy Partha Pratim , van Vugt Marieke K.
Published: November 2022

Major depressive disorder affects a large portion of the population and levies a huge societal burden. It has serious consequences like decreased productivity and reduced quality of life, hence there is considerable interest in understanding and predicting it for example using neural measures. As most of these studies have either explored resting state EEG (rs-EEG) data or task-based EEG data but not both, we seek to compare their respective efficacy. We work with data from non-clinicallydepressed individuals who score higher and lower on the depression scale and hence are more and less vulnerable to depression, respectively. Forty participants volunteered for the study. Questionnaires and EEG data were collected from participants. We found that in rs-EEG, people who are more vulnerable to depression had on average increased activity in the right temporal channel, and decreased activity in the left fronto-central and right occipital channels for raw data (rs-EEG). Intask-based EEG data, an increased activity in the central part of the brain for individuals with low vulnerability and an increased activity in right temporal, occipital and parietal regions in individuals more vulnerable to depression were found. In an attempt to predict vulnerability (high/low) to depression, we found that a Long Short Term Memory model gave the maximum accuracy of 91.42 in delta wave for task-based data whereas 1D-Convolution neural network gave the maximum accuracy of 98.06 corresponding to raw rs-EEG data. Hence if one has to look at the primary question of which data will be good for predicting vulnerability to depression, rs-EEG seems to be better than task-based EEG data. However, if mechanisms driving depressionlike rumination or stickiness are to be understood, task-based data may be more effective. Higuchi fractal dimension, phase lag index, correlation and coherence features were also found to be the most important features for predicting vulnerability todepression using rs-EEG.
Effects of Mindfulness-based Stress Reduction on Pain, Depression and Anxiety of Patients with Chronic Low Back Pain
Authors: Golsorkhi Mohadese , Khezri Noshirvan , Kheirkhah Elahe , Kermani Roxana Jabbari Nejad
Published: November 2022

BackgroundMindfulness‐based stress reduction (MBSR) reduces pain, depression, and anxiety in patients suffering from various illnesses. MBSR and other complementary/alternative therapies can be used in conjunction with prescription medications. This article examines the effectiveness of MBSR as a mind-body intervention on the level of pain, depression, and anxiety in females with chronic low back pain (CLBP).MethodsA total of thirty patients diagnosed with CLBP by physicians enrolled in this study and randomly assigned to the experimental (MBSR+ usual medical care) and the control group (usual medical care only). The Beck Depression Inventory, the Beck Anxiety Inventory, and the pain rating scale were used to evaluate participants in three-time frames: before, right away, and eight weeks following the intervention. The final data were analyzed by ANCOVA using SPSS software.Our findings showed that MBSR was influential in reducing pain severity, depression, and anxiety of patients who practiced eight meditation sessions more than patients who only received usual medical care (P<0.001).ConclusionA short MBSR course could be a useful supplemental therapy that specifically reduces pain, anxiety, and depression in patients diagnosed with chronic low back pain. In contrast, a longer course may be necessary to detect unique improvements in total anxiety and cognitive aspects of depression.
Preference Matters: Knowledge of Beneficiary’s Preference Influences Children’s Evaluations of the Act of Leaving a Choice for Others
Authors: Zang Lu , Li Dandan , Zhao Xin
Published: November 2022

People value indirect prosocial actions that benefit others as byproducts of self-oriented actions. One example of such an action is the act of leaving a choice for others when selecting an item for oneself. In this paper, we investigate how knowledge of the beneficiary’s preference may influence children’s evaluations of such actions. Children (N = 91, 4- to 10-year-olds) and adults (N = 43) were asked to evaluate characters taking a snack for themselves from a set of three items – two identical items and one unique item – in a way that either leaves a choice (two different items) or leaves no choice (two identical items) for the next person (the beneficiary). The beneficiary’s preference was systematically manipulated as unknown, preferring the unique item, or preferring the item of which there were two. We found notable developmental changes: Children as young as age 4 understand it is nicer not to take away the only thing others prefer; with age, children increasingly appreciate the value of leaving a diverse choice when the beneficiary’s preference is unknown; however, when the beneficiary clearly prefers the item of which there are two, children increasingly think it is nicer to leave two identical but preferred items than to leave a diverse choice. These findings reveal increasing flexibility and subtlety in children’s social evaluation of indirect prosocial actions; their evaluation develops from a mere understanding of the value of preference to a flexible appreciation of both preference and choice.
Emotion regulation as a mechanism of change in transdiagnostic low-intensity cognitive behavioral therapy for internalizing distress: Disaggregating within vs. between individual
Authors: De Jesús-Romero Robinson , Starvaggi Isabella , Howard Jacqueline , Peipert Allison , Buss John , Lind Colton M. , Riley Tennisha N. , Lorenzo-Luaces Lorenzo
Published: November 2022

Objective: In recent years, emotion regulation strategies such as cognitive reappraisal (CR) and expressive suppression (ES) have emerged as potential transdiagnostic mechanisms of change. Functional models of emotion dysregulation hypothesize that avoidance strategies like ES maintain internalizing distress symptoms, but these models have not received close empirical scrutiny in treatment studies. The objective of this study was to test whether week-to-week within-person changes in CR and ES predicted changes in negative affect (NA) and positive affect (PA) in a guided self-help intervention. Methods: N = 141 participants were recruited for a six-week remote trial of a guided self-help transdiagnostic CBT (NCT04870099). NA was measured with the Kessler Scale Psychological Distress Scale (K6) and PA with the World Health Organization-5 Well-being Index (WHO-5). We used the Emotion Regulation Questionnaire (ERQ) to measure CR and ES and disaggregated within- versus between-person variability using a random intercept cross-lagged panel model. Results: Participants (Mage = 40.36, SDage = 13.95, nfemale = 120, nnon-Hispanic white = 110) improved in NA, PA, CR, and ES across the trial, with the smallest improvements in ES. At the between-person level, CR was associated with both NA (r = -0.22, p = .022) and PA (r = 0.40, p < .001). At the within-person level, week-to-week changes in CR were associated with subsequent week-to-week decreases in NA (ranging from β = -0.28 to β = -0.55). Conclusions: Our findings support the role of cognitive restructuring as a mechanism of change in transdiagnostic CBT.
A Self-Compassion Experience in Immersive Video: Opportunities and Pitfalls
Authors: Landau Daniel , Hasler Béatrice , Golland Yulia , Huebbe Bennett , Idan Orly , Magnat Maya , Magidov Efrat , Friedman Doron
Published: November 2022

We have designed an immersive video experience providing participants with theexperience of an intimate encounter with themselves using immersive video. Seventy three participants (35 men, 38 women) ages 22-65 (M = 37.82, SD = 8.1) were randomly assigned to one of two conditions: meeting Self (n=38) and meeting Stranger (n=35), and the experience was carefully designed to increase self-compassion. The participants in the Self condition found the experience significantly more meaningful than those in the control condition (t(72)=-3.923, p<0.001) and reported higher active positive affect (t(72)=-2.353, p=0.021). However, our results indicate that the experience (interacting with self) negatively affected self-esteem, self-kindness and self-isolation (reverse coded) as compared to the control group (interacting with a stranger). Furthermore, the results indicate that older individuals may benefit more from the experience than younger individuals, and suggest that BMI is also an important moderating variable. Overall, our conclusion is that meeting yourself in VR can be a very powerful experience, but further studies are necessary in order to understand the contribution of experience design decisions and moderating variables,if this is intended as a positive experience.
Reappraising the role of dopamine in adolescent risk-taking behavior
Authors: França Thiago Fonseca Alves , Pompeia Sabine
Published: November 2022

Adolescence is characterized by increased risk-taking, which is often ascribed to developmental changes in dopaminergic signaling. These behaviors are believed to result from dopamine-induced hypersensitivity to rewards which overrides cognitive self-control mechanisms that are still immature at this age. However, the link between dopaminergic changes and adolescent behavior is often based on oversimplified notions about the workings and functions of dopaminergic pathways. Here we discuss the relationship between changes in the dopaminergic system and adolescents’ impulsive and risky behaviors in light of current evidence and theories about the roles of dopamine in behavior. We show that dopamine is much more strongly linked to learning, adaptive decision-making under uncertainty and increased motivation to work for rewards than to recklessness, reward-pursuit and/or choice impulsivity. Importantly, changes in the dopaminergic system also contribute to the maturation of cognitive control abilities through a variety of mechanisms, contrary to the false dichotomy between reward processing and cognitive control. Finally, we note that the functions dopamine is implicated in also involve a number of other neuromodulator systems, which interact with dopamine and also change during adolescence. These other neuromodulator systems have largely been ignored in the field of adolescent development, but a full understanding of adolescent behavior requires these neurochemicals and their interactions with dopamine to be taken into account.
A comparison of closed and open vaginal vault closure during abdominal hysterectomy
Authors: Pradhan Malla Anagha , Pradhan Binita , Sharma Paban , Thapa Bijaya
Published: November 2022

Introduction: Hysterectomy is one of the most frequently performed major surgical procedure. Majority of the hysterectomies are still done by the means of abdominal route. Despite its common performance, there are no grade A recommendations or guidelines regarding closure of vaginal vault. Surgical technique of hysterectomy may include either closed or open vaginal vault. This study aimed to compare these two techniques in terms of duration of hospital stay, febrile morbidity, vault hematoma, vaginal bleeding, relaparatomy to provide further guidance for surgical decisions.

Method: This is a retrospective study done at Patan Hospital involving patients with total abdominal hysterectomy from January 2018 to December 2020. Data were collected from medical record. Statistical analysis was done using Statistical Packages for Social Sciences (SPSS-20). The independents sample t test was used. A p value of <0.05 were considered statistically significant

Result: Of the 280 surgeries, 205 (73.2%) had vaginal vault closed whereas 75 (26.8%) were open. Mean length of hospital stay was 7.93 days with standard deviation of 3.108. Closed and open vaginal vault techniques did not differ in terms of length of hospital stay (7.83 vs. 8.19 days; p=0.40), febrile morbidity (54.6% vs. 52%; p= 0.695). Pelvic hematoma with vaginal spotting was seen in two (0.71%) cases of closed vaginal vault.

Conclusion: Both techniques of hysterectomy gave similar outcomes regarding length of hospital stay, showed no significant difference regarding postoperative complications. Our study failed to show inferiority in favor of either of the surgical techniques.
Predictors of treatment response in cirrhotic patients with overt hepatic encephalopathy
Authors: Shrestha Roshan , Karki Sanjit , Sah Manoj , Silwal Poudyal Nandu , Khanal Ajit , Karki Binod
Published: November 2022

Introduction: Hepatic encephalopathy (HE) is a frequent complication and one of the most debilitating manifestations of liver cirrhosis, which negatively impacts patient survival. This study aims to identify the factors influencing the treatment response in patients with liver cirrhosis and HE.

Method: This was a prospective observational study conducted from July 2019 to June 2020 in a tertiary referral center of Nepal. The ethical clearance was obtained from the Institutional Review Board of the center (Reference No. 46/076/77). Patients with Liver cirrhosis with HE grade II or more were included. Standard medical therapy for HE was given to all the patients, and treatment response for the first five days post admission was recorded. The response was categorized as good response, no response and deterioration, based on improvement or deterioration of patient`s symptoms or changes in West Haven criteria.

Result: In this study total 78 patients were enrolled and included in the final analysis. The mean age was 50.17± 10.36 years and 63(80.76%) were male. Alcohol was the etiology of cirrhosis in 62(79.5%). Seventy two (92.3%)  patients had good response to the treatment, 3(3.8 %) of patients had no response and rest 3(3.8%) deteriorated. On logistic regression, high creatinine, high bilirubin and low serum protein were the predictors of non-response to standard therapy (p<0.05).

Conclusion: High serum creatinine, high bilirubin and low serum protein were the predictors of non-response to standard therapy in patients with Liver Cirrhosis with Hepatic Encephalopathy.
Endoscopic findings of acid peptic disease at low and high altitude: Kathmandu versus Rasuwa districts of Nepal
Authors: Subedi Dharma Datta , Shrestha Muza , Pokharel Biyush , Regmi Prabodh , Shah Jay Narayan
Published: November 2022

Introduction: Features of Acid Peptic Disease (APD) have specific presentations from low to high altitudes. This study aims to compare the endoscopy findings of APD at low altitudes (Kathmandu Valley) and High Altitudes (Rasuwa District) of Nepal.

Method: Endoscopy findings of APD patients from Nov 2017 to Dec 2021 at Manmohan Medical College and Teaching Hospital (MMTH) were reviewed from the data kept in the endoscopy unit to compare the findings in patients from low altitudes (Kathmandu valley) and high altitudes (Rasuwa district). Variables included were age, sex, and endoscopy findings of APD. Microsoft Excel was used for data analysis. Chi-square analysis was used for the association between APD findings and altitude. A p-value ≤0.05 was considered statistically significant.

Result: Out of 2937 APD patients, 1560 (53.1%) were male and 1377(46.9%) female, age 48.5 years (range 16-81) with 2701(91.6%) having endoscopic findings of APD. Among 2701 APDs, 1448 (88.6%) were from the low altitude of Kathmandu valley, and 1253 (96.2%) from high altitude (Rasuwa district), p-value <0.0002. There were 736(50.8%) patients with gastritis from Kathmandu vs. 695 (55.46%) from Rasuwa, followed by gastro-duodenitis 219(15.1%) vs. 32 (2.5%), duodenitis 171 (11.8%) vs. 169(13.5%) respectively.

Conclusion: The incidence of endoscopic findings of overall APD was high among patients from the high altitude of Rasuwa district compared to the low altitude Kathmandu valley of Nepal.
Cardiovascular health risk behaviors among college students of Pokhara, Nepal
Authors: Shrestha Kalpana , Shahi Nikita , Pokharel Ganga , Shrestha Chandan
Published: November 2022

Introduction: Cardiovascular diseases (CVDs) are the leading cause of death globally, taking an estimated 17.9 million lives each year. However, most cardiovascular diseases can be prevented by addressing behavioral risk factors. The objective of this study was to identify cardiovascular health risk behaviors among college students of Pokhara.

Method: Descriptive, cross sectional, web based study was conducted among 390 college students of Pokhara from 10 June to 30 July, 2021. Online self-administered structured questionnaire was used for data collection using purposive and snowball sampling technique. The collected data were analyzed using descriptive (frequency, percentage, mean, standard deviation) and inferential statistics (Chi square).

Result: In this study, smoking, tobacco use and alcohol consumption were present among 33(8.5%), 13(3.3%) and 45(11.5%) respondents respectively. Further consumption of junk food was found among 349(89.5%) followed by screen time of more than two hours among 300(76.9%) respondents. A statistically significant association was found in age (p=0.17) and gender (p<0.001) with smoking. Similarly, statistically significant association was found in gender (p<0.001)   with tobacco use and in age (p=0.028), gender (p<0.001), education (p=0.026) and family type (p=0.009) with alcohol consumption.

Conclusion: Cardiovascular health risk behaviors such as smoking, tobacco use and alcohol intake was found more among male students. Further consumption of junk food along with screen time of more than two hours was found among most of the college students.
Outcome of COVID-19 Infection in vaccinated and unvaccinated adults admitted to Patan Hospital, Nepal
Authors: Shrestha John , Sah Mukesh Kumar , Singh Bishnu Mohan , Upreti Nishan , Maskey Sujina , Jha Ashish , Dhital Bibek , Rana Bandej , Pandey Bimal , Shrestha Ashis
Published: November 2022

Introduction: The vaccine has a positive impact on reducing the severity of COIVD-19 disease-course and studies have projected 50-90% protection against severe disease. Our study aimed to find the difference in disease severity outcomes between RT-PCR positive vaccinated and unvaccinated individuals.

Method: This cross-sectional study was carried out among 417 COVID-19 cases who were admitted from June 2021 to August 2021. Collected data were fed into Microsoft-excel and analyzed using SPSS software, version- 16.0. Frequency, percentage, mean and standard deviation were calculated for descriptive analysis. To find out the association of categorical variables, Chi-square test or Fisher’s Exact test was used where appropriate. P-value <0.05 was considered significant.

Result: Out of 417 cases, 23(5.5%) were fully vaccinated i.e. 10(2.4%) with Covishield and 13(3.1%) with Vero Cell, 48(11.5%) partially vaccinated i.e. 19(4.6%) with Covishield, and 29 (6.9%) with Vero Cell and 346(83%) unvaccinated. 343(82.25%) admitted patients were discharged and 74(17.75%) died during our study period. The disposition of the patient was statistically significant (p<0.001) and found more mortality among unvaccinated cases. There was a statistical difference between the requirement of ICU admission (p=0.032) among vaccinated and unvaccinated cases. The Absolute Risk Reduction (ARR) of mortality and requirement of ICU after complete vaccination with respect to unvaccinated COVID-19 patients was 14.11%(5.14%-23.73%) and 20.50%(8.02%-32.97%) respectively at 95% CI.

Conclusion: Vaccination reduces Mortality, the requirement of ICU, and oxygen requirement among COVID-19 cases with respect to unvaccinated COVID-19 cases.
Psychological distress and marital satisfaction among the spouses of patients with alcohol dependence syndrome attending Patan Hospital
Authors: Shrestha Sneha
Published: November 2022

Introduction: Alcohol dependence is considered as an ongoing stressor for individual and family. Among them, spouses are primarily affected because of intimate nature of their relationship. Spouses play an important role in treatment programs related to alcohol and thus there is a need to study psychological distress and marital satisfaction in order to understand and address such issues. Thus, this study aims to identify prevalence of psychological distress and marital satisfaction among spouses of ADS patients.

Method: This was cross-sectional study was conducted at Patan Hospital in Nepal. A total of 92 spouses of patient with alcohol dependence syndrome were selected by purposive sampling were assessed using self-administered questionnaire. Psychological Distress and Marital Satisfaction was assessed using DASS 21 and Marital Satisfaction Scale respectively. The descriptive statistics was calculated for socio demographic and association and correlation between marital satisfaction status and psychological distress was done using chi square test and Spearman’s rank correlation coefficient respectively.

Result: Majority of respondents had anxiety 59(64.13%) followed by depression 52(56.52%) and 19(20.65%) perceived stress. There was significant association between the psychological distress (Depression, Anxiety and Stress) and marital dissatisfaction in spouses (p-value = <0.05) whereas there was negative correlation with each other.

Conclusion: Psychological distress in spouses of alcohol dependent patient is high, with marital satisfaction being low. Addressing these issues will be beneficial as spouses have important role for prompt treatment of alcohol dependence syndrome and also prevents from deterioration of spouse’s mental state.
Prospects for the application of the medicinal plant Withania somnifera for biotechnological production of pharmaceuticals
Authors: Mikhaylova E.V.
Published: November 2022

Withania somnifera (L.) Dunal, also known as ashwagandha or Indian ginseng, is widely used in traditional oriental medicine. Modern research confirms the applicability of withanolides and other compounds from withania roots in treatment of various diseases. However, the massive gathering of W. somnifera for the purposes of traditional medicine puts the species at risk of extinction. Since this plant is sensitive to climatic conditions, production of W. somnifera hairy root cultures in bioreactors is the most promising cultivation method. This method allows to produce biomaterial of high purity, with a stable content of biologically active substances. A large amount of data has been obtained on the optimal conditions for accumulation of biomass, increasing the content of withanolides and their extraction from the roots of W. somnifera. The review of data suggests good prospects for the production of pharmaceuticals to treat a wide range of diseases.
Role of phosphatase enzymes in soil phosphorus mobilization by Pantoea brenneri strains
Authors: Sokolnikova L.V. , Bulmakova D.S. , Nevzorova J.V. , Suleimanova A.D.
Published: November 2022

Bacteria of the Pantoea genus have a positive effect on the growth and development of plants. In the genome of the P. brenneri strain3.5.2 we identified genes and genetic clusters associated with their multiple PGP-properties, previously confirmed by biochemical and microbiological methods. The strains are capable of hydrolyzing soil phytates and are active against inorganic soil phosphates: hydroxyapatite, phosphorite, and tricalcium phosphate. The gcd and pqqE genes responsible for the production of gluconic acid involved in the processes of phosphorus mobilization were identified. When grown on media with various sources of unavailable phosphorus, P. brenneri strains were able to secrete acid and alkaline phosphatases, the activity of which depended on the time of bacterial cultivation and the source of phosphate in the medium.
The methylation analysis of histamine receptor genes HRH1 and HRH2 in asthma patients and healthy individuals
Authors: Savelieva O.N. , Karunas A.S. , Fedorova Yu.Yu. , Vlasova A.O. , Khusnutdinova E.K.
Published: November 2022

Bronchial asthma is one of the most common chronic respiratory diseases. Histamine is a central mediator of inflammation which plays an important role in airway obstruction and bronchial secretion. Epigenetic studies of asthma patients confirm the association between the epigenetic regulation of gene expression and the pathogenesis of this disease. In recent years, an increasing number of differentially methylated CpG sites associated with the risk of asthma development and clinical course was identified. The aim of this work was to carry out a comparative analysis of the degree of methylation of the histamine receptor genes HRH1 and HRH2 promoter regions between with asthma patients and individuals of the control group from the Republic of Bashkortostan (RB). DNA samples isolated from the peripheral blood of 157 asthma patients and 155 controls under 18 years of age of Russian and Tatar ethnicity were used as the study material. MS-HRM analysis of the promoter region of the histamine receptor H1 gene HRH1 showed that the methylation level of this region varies from 90% to 100%. A significantly higher frequency of complete methylation (100%) of the promoter region of the HRH1 gene was found in patients with asthma compared to controls. MS-HRM analysis of the promoter region of the histamine receptor H2 gene HRH2 showed that the methylation level of this region was from 0% to 10%; no significant differences in the frequency of different methylation levels in asthma children and individuals from the control group were found. Thus, differential methylation of the promoter region of the HRH1 gene between asthma patients and controls was found confirming the involvement of the epigenetic mechanism of DNA methylation in the disease pathogenesis.
In silico model of epigene network capable of generating and maintaining phenotypical heterogeneity of a bacterial population
Authors: Galimzyanov A.V.
Published: November 2022

A discrete-continuous model of a molecular genetic system for controlling the differential activity of genes in cells of a clonal population of bacteria has been constructed. The system consists of a 3-operon oscillator and a pair of 2-operon triggers interconnected by transcriptional repressors. The model takes into account the main kinetic parameters of gene expression: gene product synthesis and degradation rates, threshold concentrations of transcription factors, and time delays. The system has one periodic mode (with an active oscillator) and two equilibrium states (with an inactivated oscillator). The possibility of coexistence of modes is determined by the ratios of the gene products synthesis and degradation rates of all three dynamic modules of the system. Computer experiments were carried out under conditions simulating the exponential growth of the cell population, taking into account the linear growth of the individual cell volume in the cell cycle. It was shown that in a wide range of the kinetic parameter values, each mode can be stably inherited in a number of cell divisions. This property refers the gene network to the class of epigenes – special hereditary units in which part of the hereditary information is stored, encoded and transmitted to progeny beyond the primary structure of genomic DNA molecules. The model revealed a typical ratio of network gene expression rates at which a growing cell population splits, initially epigenetically homogeneous (the initial state is the periodic mode), into three subpopulations that differ in the epigenetic status of the cells that form them (alternative patterns are the periodic mode and two equilibrium states). Corresponding cell epigenotypes can differ in null, low or high expression of the target genes and, thus, determine the adaptive strategies for both natural and epigenetically modified bacteria.
“Language Lives in Our Bodies Not Just in Our Heads”: Embodied Reading and Becoming Beyond the Molar
Authors: Carroll Shawna M.
Published: November 2022

This article focuses on one aspect of a literacy research project: how reading and language enable embodied processes that allow for fluidity and becomings outside of the static, molar normative discourse in society and consequently in language education. I explain how one research participant continues becoming outside of white settler-colonial understandings of bilingual-immigrant-racialized-woman, through reading a counternarrative fiction in a book club. Using a feminist Deleuzian methodology, I blend different data to make connections drawing on Coloma, Deleuze and Guattari, and Sumara. Through the analysis of one hot spot, I explain how the participant continues becoming through her self-identification as a speaker of Spanish and English, Venezuelan, Latinx immigrant-settler woman, in ways that resist molar, binary white settler-colonial understandings of her subject positions within education and literature, and how she creates a more liveable life through molecularity or fluidity. The inclusion of counternarrative fiction is pertinent for language classrooms, as creating a more liveable life beyond white settler-colonial binaries through embodied processes of reading fiction creates many possibilities for minoritized students.
Locating Language-Teacher Identities in the Settler-Colonial Universe
Authors: Detwyler Dmitri
Published: November 2022

The practice of English language teaching has long been an important part of socializing transnational migrants and international students into ongoing English-dominant settler-colonial projects in North America and beyond. The professional activities, knowledge, and identities of English language instructors are therefore central to the reproduction of the settler-colonial order. In this article, I investigate the relationship between language-teacher identities and settler-colonial discourses of raciolinguistic differentiation and hierarchy in Canada. Working in a discursive constructionist conceptual framework, I adopt occasioned semantics to analyze excerpts from research interviews with two ELT instructors in post-secondary and adult ESL contexts. I demonstrate how these instructors’ talk about students and languages performed language-teacher identities-in-discourse and argue that these performances reflected and contributed to reproduction of settler-colonial discourse patterns. I further suggest that settler colonialism constitutes for ELT practice in Canada a hermetic “universe” with its own internal logics and relations that must be examined and made explicit through reflection. Some pedagogical implications of this analysis include the need for ELT instructors as well as English-language teacher educators to develop an awareness of local settler-colonial histories, teach for truth and reconciliation, and embrace strategies for de-naturalizing the settler-colonial “universe” as they create spaces of possibility for decolonization to be carried out. One research implication is that language-teacher identity scholarship would be strengthened by embracing epistemological and methodological decolonization.
DEVELOPMENT OF “UIS” WOVEN LEARNING BASED ON KARO’S CULTURAL VALUES IN VOCATIONAL HIGH SCHOOLS
Authors: Nurhayati Tanjung  , Dina Ampera  , Farihah  , Veronika Sinukaban  , Siti Wahida
Published: November 2022

This study aims to develop a learning model of UIS weaving based on the relevant Karo cultural values in schools. The research uses research and development through the Borg and Gall model development approach. The research subjects were the teachers and students of the Vocational School (SMK) Negeri 1 Berastagi where the research was conducted. Data collection techniques using observation and interviews. The data analysis technique used a qualitative descriptive technique. The research findings can be described as follows. First, the relevant Uis Karo weaving learning model used for the cultivation of Karo cultural values is Carl Rogers' version of the nondirective learning model. Second, modification and adjustment of this learning model are carried out so that it can be used to instill Karo's cultural values, especially those related to the format of the lesson plan. Third, teachers can carry out Uis Karo weaving learning using a non-directive model for planting Karo cultural values by the applicable curriculum in schools while still paying attention to the Karo regional government policy regarding the development of a Karo ethnic-based curriculum. The results of the study found that noble values formulated in various expressions need to be given to students, among others; Uis Karo is a culture of the Karo tribe. Uis Karo is a set of traditional clothes used in cultural activities. Uis (cloth) means clothing in Karo so that its development has made uis into various types, styles, and functions. Uis is made from cotton, spun, and woven manually using looms instead of machines. The composition of the yarn as the basic material for Uis uses cotton yarn with natural dyes, but some also use factory fabrics that are dyed with chemical dyes. Some of this uis are rare because they are no longer used in everyday life, or are only used in cultural ritual activities related to animist beliefs and are no longer practiced.
Впровадження дистанційного навчання в освітній процес медичних закладів вищої освіти
Authors: Khmeliar Inesa , Kushnir Lesia
Published: November 2022

У статті проаналізовано основні недоліки та переваги використання дистанційного навчання в освітньому процесі навчального закладу. В умовах розвитку сучасної системи медичної освіти особливого значення набуває рівень професійної підготовки медичних та фармацевтичних працівників. Діяльність лікувальних закладів реорганізовується на основі використання інформаційно-комунікаційних технологій та інтенсивного оновлення різної звітної інформації, тому підвищення інформаційно-цифрової компетентності учасників освітнього процесу зараз на часі. З початком пандемії COVID-19 більшість здобувачів освіти провела навчальний рік поза межами навчального закладу, що вимагає ефективного впровадження в освітній процес інформаційно-комунікативних технологій під час дистанційного навчання в умовах локдауну. Досліджено можливості створення моделі організації освітнього процесу за умов використання інформаційно-комунікативних технологій. Обґрунтовано діяльність учасників освітнього процесу при дистанційному навчанні. Аналіз літератури надав можливість зробити висновок, що використання інформаційно-комунікативних технологій (ІКТ) – складний та багатовимірний процес. Ефективність застосування інформаційно-комунікативних технологій під час навчання здобувачів освіти залежить від вміння викладача реорганізувати освітній процес на засадах студентоцентрованого, проблемного, компетентнісного і діяльнісного підходів. Це сприяє виробленню у здобувачів освіти потреби у самовдосконаленні, науковому пошуку; розвиває вміння аналізувати, спостерігати, порівнювати, робити висновки, висувати оригінальні ідеї. Висвітлено питання ролі ІКТ для учасників освітнього процесу як можливості доступу до різних джерел інформації, вдосконалення навичок роботи в операційних системах, пошуку, створенню, просування та використанню цифрових ресурсів, спілкування, співпраці та саморозвитку при організації дистанційно вебінарів, конференцій, семінарів. Це в цілому сприяє підвищенню рівня самостійності у написанні проєктів, науково-дослідницьких робіт, формуванню професійних вмінь та навичок.

З метою визначення базового рівня володіння цифровою компетентністю професорсько-викладацького складу нами проведено самооцінювання власної цифрової компетентності за 12 бальною системою.

Відмічено, що ефективність дистанційного навчання підвищується за умови реалізації освітнього процесу через студентоцентрований, проблемний, компетентнісний і діяльнісний підходи. Ефективність дистанційного навчання залежить від рівня цифрової компетентності викладача та студента, чітко обумовлених різних видів контролюючих завдань, доброзичливої атмосфери спілкування при консультуванні здобувачів освіти, аналізі помилок та рекомендацій основних шляхів усунення помилок. Виходячи з цього головними структурними компонентами організації дистанційного та змішаного навчання є: мотивуючий; змістовий; організаційний; тренувально-практичний; контролюючий; результативний.
Делегування повноважень як технологія ефективного педагогічного менеджменту
Authors: Shvardak Marianna , Halus Oleksandr
Published: November 2022

У статті окреслено передумови виникнення делегування повноважень. Визначено категоріальний апарат дослідження. Уточнено сутність ключових дефініцій (делегування повноважень, повноваження, відповідальність, технологія делегування повноважень). Визначено види повноважень (лінійне та розгалужене). Узагальнено принципи (єдиноначальності, обмеження норми керованості, відповідності прав обов’язкам, закріпленої відповідальності, проміжної звітності) і правила делегування повноважень. Виявлено типові бар’єри делегування повноважень. Розкрито специфіку застосування технології делегування в закладах освіти. Розроблено алгоритм застосування технології делегування повноважень. Окреслено переваги та недоліки делегування повноважень в умовах освітніх установ. Сформовані рекомендації керівнику сучасного закладу загальної середньої освіти для грамотного і результативного делегування повноважень.