bluuebunny/crossref_metadata_2025 huggingface dataset:
The appropriation cycle: novice and expert consumers
Authors: Stavraki Georgia , Plakoyiannaki Emmanuella , Clarke Jackie
Published: August 2018

Purpose

Recognizing the value and limitations of current knowledge of the appropriation process in the consumption of aesthetic experiences, this research aims to generate a localized account for novice and expert consumers of the varying role of cultural capital in the appropriation cycles and interpretative responses of an aesthetic experience.

Design/methodology/approach

This research uses a single case study design of Miró’s blockbuster exhibition, and draws on multiple sources of evidence, notably 50 in-depth visitor interviews, observations and archival records.

Findings

An evidence-based framework of the appropriation process for novice and expert consumers of aesthetic experiences is offered. This framework highlights the significance of appropriation pace and personal versus communal interpretations – amongst other features – in distinguishing distinct versions of the appropriation process in accordance with the varied accumulation of consumer cultural capital.

Research limitations/implications

The transferability of the findings to other aesthetic or experience-based consumption contexts such as performing arts or sports is discussed, alongside the relevance of the proposed framework for researchers of aesthetic experiences.

Practical implications

The empirical investigation of the understudied connection between visitors’ cultural capital and their museum experiences provides insights into curatorial and marketing practices in terms of broadening, diversifying and engaging museum audiences.

Originality/value

This research provides new theoretical insights into the literature of appropriation process and consumption of art experiences by bringing together consumers’ cultural capital with the appropriation process and interpretive responses to an aesthetic experience.
Migrants’ health and well-being in the context of the Greek economic crisis: a narrative review
Authors: Psoinos Maria
Published: August 2018

Purpose

Despite numerous studies on the separate health consequences of economic crises and post-migration difficulties, very little is known about the processes through which the intersection of economic crisis and post-migration adversity contribute to migrants’ health vulnerabilities. The purpose of this paper is to examine existing literature about how newly arrived and long-term migrants’ health and well-being are affected by the economic crisis in Greece.

Design/methodology/approach

The ongoing economic recession in Greece, combined with the recent migration crisis, provided an adequate context for investigating migrants’ health and well-being. A narrative literature review was performed on whether and how migrants’ health and well-being are affected by the economic and the migration crises in the particular case of Greece. Papers published between January 2010 and December 2017 were selected based on review of titles and abstracts, followed by a full text review.

Findings

The review identified a surprisingly limited number of relevant studies. Ultimately five studies were selected and their findings summarised. There was only one study attempting to unravel the specific processes through which the crisis and the post-migration problems impact cumulatively on migrants’ health and well-being and to suggest healthcare improvements. Further research on this topic is urgently needed.

Originality/value

This paper explores existing research looking at how migrants’ health and well-being are affected by the economic and the migration crises in Greece. The emerging dearth of research evidence on the above topic is also critically discussed from a socio-political point of view and recommendations are made related to healthcare practice and services set up for migrants’ health and care.
The profile of prisoners with tuberculosis in Japan
Authors: Kawatsu Lisa , Uchimura Kazuhiro , Kobayashi Makoto , Ishikawa Nobukatsu
Published: August 2018

Purpose

Although globally, prisoners are considered one of the vulnerable groups to tuberculosis (TB), little is known about the situation of TB in prison setting in Japan. The purpose of this paper is to examine the characteristics of TB among prisoners in Japan.

Design/methodology/approach

Records of TB patients from one medical prison were analyzed in terms of general demographic characteristics, clinical manifestations, risk factors and delay in diagnosis and in initiating treatment, and compared with data from the national TB surveillance and other published data on health of inmates, where appropriate. Continuous variables were compared using student independent samples t-test. Proportions were compared using χ2 or Fisher exact test as appropriate. Kaplan–Meier survival analysis was conducted to determine the time from entry to prison institution to diagnosis of TB.

Findings

A total of 49 patients were analyzed. The mean age was 49.5 (±14.3) and 69.4 percent were males. Being unemployed and homeless prior to incarceration, and several co-morbidities were potential risk factors for TB (p<0.01). Analysis of diagnosis and treatment delay showed that 16.1 percent of smear positive patients took more than a week to be placed on treatment after being diagnosed of TB. Approximately 50 percent of the patients were diagnosed within four months of entering the prison institution.

Practical implications

Several potential risk factors identified suggest the need to strengthen screening for specific sub-groups within the prison population, such as those with poor socio-economic status and co-morbidities, as well as to consider the possible role of systematic screening for latent TB infection.

Originality/value

This study presents some important data to help understand the profile of TB patients in prisons in Japan, as well as showing that a detailed epidemiological analysis of existing records can provide useful insight.
Development of healthcare facility standards for Thai female inmates
Authors: Sawasdipanich Nantaga , Puektes Supa , Wannasuntad Supaporn , Sriyaporn Ankana , Chawmathagit Chulepon , Sintunava Jirapa , Paungsawad Gamjad
Published: August 2018

Purpose

The purpose of this paper is to develop and evaluate the Standards of Healthcare Facility for Thai Female Inmates (SHF-TFI) through healthcare service improvement.

Design/methodology/approach

This research and quality improvement project was comprised of three phases. Surveying healthcare facilities and in-depth interviews with female inmates as well as prison nurses were employed in Phase I. Expert reviews and public hearing meetings were used for developing the SHF-TFI in Phase II. Satisfaction questionnaires, focus group interviews of the female inmates, and in-depth interviews with nurses and prison wardens were utilized to evaluate feasibility and effectiveness of SHF-TFI implementation in Phase III.

Findings

The SHF-TFI was elaborated in order to be more specific to the context of the correctional institutes and correspond with healthcare as to the needs of female inmates. It was divided into three main aspects: administrative standards, health service standards and outcome standards. After implementation, nurses reflected on the feasibility and benefits of the SHF-TFI on the organizations, inmates and nurses. The female inmates perceived remarkable improvement in the healthcare services including physical activity promotion and screening programs for non-communicable diseases, the physical environment and sufficiency of medical equipment. Moreover, the pregnant inmates and incarcerated mothers with children shared their views on better antenatal and child developmental care, as well as availability of baby supplies.

Originality/value

The findings support the feasibility and effectiveness of the SHF-TFI for quality care improvement and applicability of the Bangkok Rules in women’s correctional institutes.
Ethnic disparity in financial fragility in Malaysia
Authors: Abdullah Yusof Selamah
Published: August 2018

Purpose

The purpose of this paper is to investigate the extent of financial fragility and its disparity across ethnic groups in Malaysia. Disparities related to income and wealth are major concerns as they breed conflict and social instability. The study also compares the level of financial fragility of Malaysians with their neighboring Asian counterparts.

Design/methodology/approach

This study uses the World Values Survey to construct two financial fragility measures. Descriptive analysis is used to compare the level of financial fragility of Malaysia with other Asian countries. Ordinary least squares and generalized ordered logit regressions are applied to determine the existence of ethnic disparity in financial fragility in Malaysia.

Findings

There exist ethnic differences in financial vulnerability in Malaysia where Malay and Indian are in a more financially fragile situation compared to Chinese. Other socio-economic factors and character trait also impact financial fragility. Compared to neighboring countries, the level of financial fragility in Malaysia is low. Nevertheless, over 40 percent of the Malaysians are just getting by in terms of their expenditure relative to income. They may be at risk to financial shocks without adequate savings or funds.

Social implications

Ethnic disparity in financial vulnerability added to the inequality in income and wealth can pose a serious threat to Malaysia which attempts to achieve long-lasting social harmony and sustainable development.

Originality/value

This is the first study that attempts to compare the level of individual financial fragility across Asian countries. It also makes use of a larger scale survey and a more representative sample to examine ethnic disparity in financial fragility in Malaysia. In addition, character trait is included in the analysis to provide a better understanding of human behavior in affecting financial outcomes.
Experiments on learning-based industrial bin-picking with iterative visual recognition
Authors: Harada Kensuke , Wan Weiwei , Tsuji Tokuo , Kikuchi Kohei , Nagata Kazuyuki , Onda Hiromu
Published: August 2018

Purpose

This paper aims to automate the picking task needed in robotic assembly. Parts supplied to an assembly process are usually randomly staked in a box. If randomized bin-picking is introduced to a production process, we do not need any part-feeding machines or human workers to once arrange the objects to be picked by a robot. The authors introduce a learning-based method for randomized bin-picking.

Design/methodology/approach

The authors combine the learning-based approach on randomized bin-picking (Harada et al., 2014b) with iterative visual recognition (Harada et al., 2016a) and show additional experimental results. For learning, we use random forest explicitly considering the contact between a finger and a neighboring object. The iterative visual recognition method iteratively captures point cloud to obtain more complete point cloud of piled object by using 3D depth sensor attached at the wrist.

Findings

Compared with the authors’ previous research (Harada et al., 2014b) (Harada et al., 2016a), their new finding is as follows: by using random forest, the number of training data becomes extremely small. By adding penalty to occluded area, the learning-based method predicts the success after point cloud with less occluded area. We analyze the calculation time of the iterative visual recognition. We furthermore make clear the cases where a finger contacts neighboring objects.

Originality/value

The originality exists in the part where the authors combined the learning-based approach with the iterative visual recognition and supplied additional experimental results. After obtaining the complete point cloud of the piled object, prediction becomes effective.
A neural network based monitoring system for safety in shared work-space human-robot collaboration
Authors: Rajnathsing Hemant , Li Chenggang
Published: August 2018

Purpose

Human–robot collaboration (HRC) is on the rise in a bid for improved flexibility in production cells. In the context of overlapping workspace between a human operator and an industrial robot, the major cause for concern rests on the safety of the former.

Design/methodology/approach

In light of recent advances and trends, this paper proposes to implement a monitoring system for the shared workspace HRC, which supplements the robot, to locate the human operator and to ensure that at all times a minimum safe distance is respected by the robot with respect to its human partner. The monitoring system consists of four neural networks, namely, an object detector, two neural networks responsible for assessing the detections and a simple, custom speech recognizer.

Findings

It was observed that with due consideration of the production cell, it is possible to create excellent data sets which result in promising performances of the neural networks. Each neural network can be further improved by using its mistakes as examples thrown back in the data set. Thus, the whole monitoring system can achieve a reliable performance.

Practical implications

Success of the proposed framework may lead to any industrial robot being suitable for use in HRC.

Originality/value

This paper proposes a system comprising neural networks in most part, and it looks at a digital representation of the workspace from a different angle. The exclusive use of neural networks is seen as an attempt to propose a system which can be relatively easily deployed in industrial settings as neural networks can be fine-tuned for adjustments.
Critical success factors for Lean implementation in IT outsourcing relationships
Authors: Blijleven Vincent , Gong Yiwei , Mehrsai Afshin , Koelemeijer Kitty
Published: August 2018

Purpose

Following positive results of Lean implementation in manufacturing environments, Lean has become an emerging philosophy for clients and suppliers of information technology (IT) services. However, how to implement Lean in IT outsourcing relationships has been addressed sparsely in academic literature. The purpose of this paper is to investigate critical success factors (CSFs) for implementing Lean in IT outsourcing relationships. Key findings, implications and avenues for future research are discussed.

Design/methodology/approach

Six IT outsourcing relationships were qualitatively investigated by means of 36 semi-structured interviews. CSFs were identified based on interview transcription analyses, selection techniques and expert reviews.

Findings

In total, 16 CSFs for Lean implementation in IT outsourcing relationships are identified and described.

Practical implications

The CSFs presented in this paper indicate key areas that deserve managerial attention to steer Lean implementation efforts in IT outsourcing relationships in a favorable direction.

Originality/value

This study is the first to describe the phenomenon of “Lean IT outsourcing” and provides researchers and practitioners with a foundation to further examine Lean implementation in IT outsourcing relationships.
Different methods to fuzzy X¯-R control charts used in production
Authors: Ercan Teksen Hatice , Anagun Ahmet Sermet
Published: August 2018

Purpose

The control charts are used in many production areas because they give an idea about the quality characteristic(s) of a product. The control limits are calculated and the data are examined whether the quality characteristic(s) is/are within these limits. At this point, it may be confusing to comment, especially if it is slightly below or above the limit values. In order to overcome this situation, it is suitable to use fuzzy numbers instead of crisp numbers. The purpose of this paper is to demonstrate how to create control limits of

X
¯

-R control charts for a specified data set of interval type-2 fuzzy sets.

Design/methodology/approach

There are methods in the literature, such as defuzzification, distance, ranking and likelihood, which may be applicable for interval type-2 fuzzy set. This study is the first that these methods are adapted to the

X
¯

-R control charts. This methodology enables interval type-2 fuzzy sets to be used in

X
¯

-R control charts.

Findings

It is demonstrated that the methods – such as defuzzification, distance, ranking and likelihood for interval type-2 fuzzy sets – could be applied to the

X
¯

-R control charts. The fuzzy control charts created using the methods provide similar results in terms of in/out control situations. On the other hand, the sample points depicted on charts show similar pattern, even though the calculations are different based on their own structures. Finally, the control charts obtained with interval type-2 fuzzy sets and the control charts obtained with crisp numbers are compared.

Research limitations/implications

Based on the related literature, research works on interval type-2 fuzzy control charts seem to be very limited. This study shows the applicability of different interval type-2 fuzzy methods on

X
¯

-R control charts. For the future study, different interval type-2 fuzzy methods may be considered for

X
¯

-R control charts.

Originality/value

The unique contribution of this research to the relevant literature is that interval type-2 fuzzy numbers for quantitative control charts, such as

X
¯

-R control charts, is used for the first time in this context. Since the research is the first adaptation of interval type-2 fuzzy sets on

X
¯

-R control charts, the authors believe that this study will lead and encourage the people who work on this topic.
An ICT-based framework to improve global supply chain integration for final assembly SMES
Authors: Cragg Tony , McNamara Tom
Published: August 2018

Purpose

To access new markets and improve sourcing practices small to medium sized manufacturing companies (SMEs) increasingly seek suppliers and customers in distant countries. Yet these new relationships with global partners often pose problems of an agency nature. The purpose of this paper is to directly address these challenges through the proposal of an information and communication technology (ICT)-based framework.

Design/methodology/approach

There has been very little research into how lead SMEs manage their global supply chains and the challenges they face. This paper uses a case study investigation to analyze how four French SMEs – final assemblers of machinery in the farming and agri-business sector – manage their international supply chains.

Findings

It was observed that the relationships and interactions between the SMEs and their immediate upstream and downstream partners were dominated by the agency problem and fell into six distinct categories (termed “barriers” to effective supply integration), namely; asymmetries, contractual design, supplier dependence, product specifications, supply chain complexity and performance monitoring.

Originality/value

The contribution of this paper is that a conceptual frame work was developed in which ICT solutions are offered to help address the barriers to supply chain integration, thus reducing the overall risk exposure due to externalities and problems of agency.
ECM implementations in practice: objectives, processes, and technologies
Authors: Jaakonmäki Roope , Simons Alexander , Müller Oliver , vom Brocke Jan
Published: August 2018

Purpose

Enterprise content management (ECM) is an important topic in information management, but researchers have long had difficulty developing a consistent definition. The purpose of this paper is to analyze ECM case reports from practice to identify ECM’s objectives, processes and technologies and to provide a foundation on which ECM can be conceptualized and defined.

Design/methodology/approach

This paper assembles more than 1,200 case reports on industrial ECM implementations in order to characterize the ECM concept from a practitioner’s viewpoint. The paper provides a descriptive overview and historical examination of ECM implementations over time and across countries and industries, grounded in a structured content analysis.

Findings

Even though the case reports share some commonalities, their ECM projects differ considerably in terms of their objectives, processes and technologies, and vary widely across countries and industries. In addition, ECM implementations are much broader today than they once were, so the scope and boundaries of the ECM concept are increasingly blurred in practice.

Originality/value

While several researchers have characterized the ECM concept based on literature reviews, only a few have approached the definition problem from a practical viewpoint. This paper provides a foundation from which to evaluate how well researchers’ conceptualizations of ECM match current business practice.
Adapting through learning and knowledge acquisition: the cases of four global family firms
Authors: Duarte Alonso Abel , Kok Seng
Published: August 2018

Purpose

The purpose of this paper is twofold: first, to investigate the importance of knowledge as a tool for adaptation and competitive advantage through qualitative research, exploring the cases of four global family firms; and second, to develop a theoretical framework based on the knowledge-based view (KBV) of the firm to facilitate understanding of learning and knowledge acquisition among family firms.

Design/methodology/approach

This investigation focusses on the cases of four family firms, two operating in a developed (Australia), and two in an emerging economy (Uruguay). In-depth, face-to-face interviews were conducted with firm owners, co-owners and one manager.

Findings

Regardless of firms’ operating environment (OECD, emerging economy), similar outcomes were revealed. Indeed, firm management’s ability to gather, contextualise and synthesise knowledge, including tacit knowledge, emerged as crucial to adapt to new challenges in their business environment. Several tenets of the KBV emerged, including those associated with knowledge to solve emerging problems, specialisation through knowledge acquisition and applying specialised knowledge to produce. Importantly, firms’ ability to anticipate future events through tacit or new knowledge acquisition became evident.

Originality/value

The study makes two key contributions that represent originality and value. First, the presented theoretical framework facilitates understanding of various dimensions of knowledge, their resulting influence on firms’ preparedness to adapt to events in their business environment, and potential implications on their competitive advantage. Second, by qualitatively examining the participating family firms, the study addresses a recognised research gap, notably, that research investigating this group has been predominantly quantitative.
Can microblogs motivate involvement in civic and political life? Examining uses, gratifications and social outcomes among Chinese youth
Authors: Pang Hua
Published: August 2018

Purpose

The purpose of this paper is to explore the Chinese microblog users’ psychological motivations and the association between users’ motivations and their offline civic and political engagement. Specifically, this study examines what the psychological impetuses of Weibo use are and how they promote the young citizens’ civic and political involvement.

Design/methodology/approach

The data were collected through the web-based survey with a total sample of 426 people. Principal components factor analysis, correlation analysis, and hierarchical multiple regressions were sequentially carried out to address the research questions.

Findings

The findings reveal that there are four major motives for using Weibo: information, socializing, recognition seeking and entertainment. Interestingly, seeking social needs is positively and significantly related to increasing young people’s civic participation, but not political participation.

Research limitations/implications

Theoretically, the research demonstrates that the uses and gratifications is a suitable approach for analysis of psychological antecedents of Weibo use and subsequent outcomes. Practically, it will help understand the dynamics of how the new media technology may engender democratic development and change.

Originality/value

Although the growing significance of social media has drawn considerable attention, little research has been conducted to assess the political consequences of Weibo. The current study fills the void by investigating whether Weibo functions as an effective tool to facilitate democratic engagement in contemporary China. The obtained results may provide insight into the relationship between the gratification structures and engagement in other social settings.
Aspartate metabolism is involved in the maintenance of enterohaemorrhagic Escherichia coli O157:H7 in bovine intestinal content
Authors: Bertin Yolande , Segura Audrey , Jubelin Gregory , Dunière Lysiane , Durand Alexandra , Forano Evelyne
Published: August 2018

The gastrointestinal tract (GIT) of healthy cattle is the main reservoir of enterohaemorrhagic Escherichia coli (EHEC). Therefore, it is crucial to better understand the physiology of EHEC in the bovine GIT. In this study, we demonstrate that aspartate present in bovine small intestine content (BSIC), was exhausted after incubation of the reference EHEC strain EDL933 but was poorly assimilated by the endogenous microbiota. Furthermore, the bovine commensal E. coli strain BG1 appeared less efficient than EDL933 in aspartate assimilation suggesting a competitive ability of EHEC to assimilate this amino acid. Our results strongly suggest that aspartate, internalized via the DcuA aspartate: succinate antiporting system, is then converted to fumarate and carbamoyl‐aspartate, the precursor for UMP biosynthesis. Aspartate assimilation by these two pathways conferred a competitive growth advantage to EHEC in BSIC. In summary, supply of intracellular fumarate due to aspartate deamination and used as an electron acceptor for anaerobic fumarate respiration, as well as de novo synthesis of pyrimidine from aspartate appear to be important pathways favouring EHEC persistence in the bovine gut. Aspartate probably represents an ecological niche for EHEC in the bovine small intestine.
Calcium–Polystyrene Sulfonate Decreases Inter‐Dialytic Hyperkalemia in Patients Undergoing Maintenance Hemodialysis: A Prospective, Randomized, Crossover Study
Authors: Wang Jing , Lv Meng‐Meng , Zach Odeh , Wang Ling‐Yu , Zhou Meng‐Ying , Song Gui‐Rong , Zhang Xu , Lin Hong‐Li
Published: August 2018

Hyperkalemia is a life‐threatening emergency in maintenance hemodialysis (MHD) patients. This clinical trial investigated the efficacy and safety of calcium–polystyrene sulfonate (Ca‐PS) in MHD patients with interdialytic hyperkalemia. A total of 58 hemodialysis patients with hyperkalemia (≥5.5 mol/L) were selected and administered either a 3‐week Ca‐PS (3 × 5 g/day) or a blank control following the model of a prospective, randomized, crossover clinical trial with a 1‐week washout period. All patients were followed up for another 3 weeks for safety evaluations. The primary outcome was the magnitude of the change in serum potassium levels. The secondary outcomes were electrocardiography (ECG) changes and treatment safety (volume overload, electrolyte imbalance). Compared with the control group, Ca‐PS treatment significantly reduced serum potassium levels (P <0.01). More patients in the Ca‐PS group had lower serum potassium levels than the safety level of <5.5 mmol/L (32% for control vs. 61% for Ca‐PS, P <0.01). Peaked T‐wave occurred less frequently in patients in the Ca‐PS group (13.8% for Ca‐PS vs. 31.03% for control, P <0.01). In addition, Ca‐PS reduced serum phosphorus levels with no effects on serum levels of calcium and sodium, fluid volume, blood pressure, or interdialytic weight gain. Ca‐PS treatment decreases serum levels of potassium and phosphorus in MHD patients with interdialytic hyperkalemia. Ca‐PS does not induce volume overload or disrupt electrolyte balance.
Cutaneous anaesthesia of hip surgery incisions with iliohypogastric and subcostal nerve blockade: A randomised trial
Authors: Nielsen Thomas D. , Moriggl Bernhard , Barckman Jeppe , Jensen Jan Mick , Kølsen‐Petersen Jens A. , Søballe Kjeld , Børglum Jens , Bendtsen Thomas Fichtner
Published: August 2018

Background

Cutaneous nerve blockade may improve analgesia after hip surgery. Anaesthesia after the lateral femoral cutaneous (LFC) nerve block is too distal for complete coverage of most hip surgery incisions, which requires additional anaesthesia of the adjacent, proximal area. The transversalis fascia plane (TFP) block potentially anaesthetises the iliohypogastric and subcostal nerves. The primary aim of the present study was to investigate, if the TFP block provides cutaneous anaesthesia adjacent to the LFC nerve block.

Methods

Active vs placebo TFP blocks were compared in a paired randomised controlled trial (RCT) in 20 volunteers, who all had bilateral LFC nerve blocks. The day preceding the RCT, the area anaesthetised by a novel selective ultrasound guided subcostal nerve block was identified bilaterally in order to assess the contribution of the subcostal nerve to the area anaesthesia by the TFP block.

Results

Anaesthesia of the lateral hip region after TFP block was 80%. The cutaneous anaesthesia after active TFP block was in continuity with the LFC nerve block in 65%. Combined TFP and LFC nerve blockade significantly increased the coverage of hip surgery incisions compared to LFC nerve block alone. The success rate of blocking the subcostal nerve was 50% with the TFP block.

Conclusion

The TFP block anaesthetises the skin proximal to the LFC nerve block by anaesthetising the iliohypogastric and subcostal nerves. TFP block as a supplement to LFC nerve block improves the coverage of the proximal surgical incisions used for hip surgery.
Health benefits of an adverse events reporting system for chronic pain patients using long‐term opioids
Authors: Planelles Beatriz , Margarit César , Ajo Raquel , Sastre Yolanda , Muriel Javier , Inda María‐del‐Mar , Esteban María D. , Peiró Ana M.
Published: August 2018

Background

Safety data from long‐term opioid therapy in the real world has been poorly studied in chronic non‐cancer pain (CNCP). The aim was to design a pharmacovigilance data recording system and assess whether participation in this recording system improves pain management, enhancing patient′s health status.

Methods

A pharmacovigilance data recording system was conducted during 24 months. Data were self‐reported by patients (pain, adverse events [AEs] and healthcare resources use) and physicians (morphine equivalent daily dose [MEDD] prescribed and suspected adverse drug reaction [ADRs]). Outcomes from patients with (case) or without (controls) suspected ADRs and cases follow‐up were also compared with Spanish Pharmacovigilance System data.

Results

A total of 753 patients were recruited in 897 visits. Fentanyl and tramadol were the most prescribed opioids, 89% with concomitant drugs, pregabalin being the one with the most potential drug interactions. Cases presented significantly higher pain intensity (VAS 67 ± 26 vs 59 ± 30 mm, P < 0.05), number of AEs (8 ± 6 vs 5 ± 3 AEs/patient, P < 0.01), polypharmacy related to pain (65% vs 34%, P < 0.01) and MEDD (139 ± 130 vs 106 ± 99 mg/d, P < 0.01) than controls. Furthermore, cases presented significant higher changes in pharmacological pain therapy due to pain, unplanned emergency visits and hospital admission than controls. Physicians notified 168 suspected ADRs mostly related to neurological or psychiatric events and 8% of them were previously unknown.

Conclusions

This data recording system provided important information to achieve a better control of CNCP pharmacological pain therapy, improving patient's health status and reducing costs to the Health System.
Genome‐wide association mapping and examination of possible maternal effect for the pace trait of horses
Authors: Amano T. , Onogi A. , Yamada F. , Kawai M. , Shirai K. , Ueda J.
Published: August 2018

Previously, a single nucleotide polymorphism (SNP) related to gait type was identified at position 22 999 655 of chromosome 23 in the coding region of DMRT3 (DMRT3:Ser301Ter) by showing that a cytosine (C) to adenine (A) mutation of this SNP induced pace in the Icelandic horse. We investigated the effect of DMRT3:Ser301Ter on the gait of Hokkaido Native Horses, a Japanese native breed, and examined genetic factors other than DMRT3 by exploring genome‐wide SNPs related to gait determination. All animals exhibiting pace were AA for DMRT3:Ser301Ter, confirming the association of DMRT3:Ser301Ter with gait determination; however, 14.3% of the animals exhibiting trot also had AA for DMRT3:Ser301Ter, suggesting the presence of another factor(s) cooperatively working with DMRT3:Ser301Ter for gait determination. SNPs on chromosomes 13 and 23 were detected by genome‐wide association analysis (false discovery rate <0.05), although SNPs on chromosome 23 were all located in the vicinity of DMRT3:Ser301Ter, confirming the association with DMRT3. A genome‐wide association study targeting only animals with AA for DMRT3:Ser301Ter to examine genetic factors cooperatively working with DMRT3:Ser301Ter for gait determination suggested associations of 23 SNPs on six chromosomes. In a series of analyses of the effect of a maternal factor (dam's gait) on gait determination, the effect was suggested in comparison of the frequencies of exhibiting pace in gait checks in only two animal groups having dams with different DMRT3:Ser301Ter genotypes (P < 0.05), suggesting that the gait of the dam does not have a major effect on whether progeny homozygous for the DMRT3:Ser301Ter mutation will preferentially pace or trot.
Biochemical efficacy of tioguanine in autoimmune hepatitis: a retrospective review of practice in the Netherlands
Authors: van den Brand Floris F. , van Nieuwkerk Carin M. J. , Verwer Bart J. , de Boer Ynto S. , de Boer Nanne K. H. , Mulder Chris J. J. , Bloemena Elisabeth , Bakker Christine M. , Vrolijk Jan M. , Drenth Joost P. H. , Tan Adriaan C. I. T. L. , ter Borg Frank , ter Borg Martijn J. , van den Hazel Sven J. , Inderson Akin , Tushuizen Maarten E. , Bouma Gerd
Published: August 2018

Background

Azathioprine (AZA) and mercaptopurine (MP) are the cornerstone of steroid‐sparing strategies in autoimmune hepatitis (AIH). Up to 20% of patients do not tolerate or respond to these regimens.

Aim

To evaluate retrospectively the tolerability and efficacy of tioguanine (thioguanine) (TG) therapy in selected patients with AIH and AIH variant syndromes.

Methods

Records of 52 patients who received TG therapy were retrieved from nine hospitals in the Netherlands. Indications for TG treatment were intolerable side effects on AZA or MP (n = 38), insufficient response (n = 11) or first‐line treatment (n = 3). Treatment efficacy was defined as normalisation of serum aminotransferases and serum immunoglobulin G.

Results

No serious adverse events occurred in patients treated with TG during a median follow‐up of 18 months (range 1‐194). Treatment was well tolerated in 41 patients (79%), whereas four had tolerable (8%) and seven (13%) intolerable side effects. Thirty‐eight patients were treated with TG after intolerable side effects on AZA or MP; 29 patients continued TG therapy of whom 24 (83%) achieved complete biochemical remission, four (14%) had incomplete and one (3%) had no response; nine discontinued treatment. Seven of 11 patients with insufficient response to AZA or MP were responsive to TG, three with complete and four with incomplete biochemical remission; four discontinued due to intolerance (n = 2) and non‐response (n = 2). TG was effective in all AIH patients as first‐line maintenance treatment.

Conclusion

In our retrospective review of TG therapy in selected patients with AIH or AIH variants who previously failed on AZA or MP, TG appeared tolerable with biochemical efficacy.
Gamification approaches to the early stage of innovation
Authors: Patrício Rui , Moreira António C. , Zurlo Francesco
Published: August 2018

Despite the growing adoption and acceptance of gamification approaches among firms, the relationship between gamification and the early stage of innovation is confusing and deserves further attention in order to produce added‐value exploratory knowledge. This paper puts forward the idea that gamification approaches can support the early stage of innovation by making a cross‐comparison of published case studies of firms where gamification was used to address innovation challenges, e.g. use of gamification elements and tools that support the generation of ideas for developing new product concepts or entering new markets. In order to understand and clarify the relationship between gamification and the early stage of innovation, the paper proposes an analytical framework that provides a consistent and organized picture of the use of gamification approaches for innovation purposes. Research findings provide a conceptualization of gamification in the context of the early stage of innovation and demonstrate significant outcomes of these types of approaches with regard to the various forms of engagement, team spirit, consensus building, knowledge transfer, creative thinking and productivity.
A longitudinal investigation of trust beliefs in physicians by children with asthma and their mothers: Relations with children's adherence to medical regimes and quality of life
Authors: Rotenberg Ken J. , Petrocchi Serena
Published: August 2018

Objective

The study examined the relations between trust beliefs in physicians, adherence to prescribed medical regimes, and quality of life for children with asthma and their mothers.

Methods

One hundred forty‐three children with asthma (116 males, M = 12 years–7 months) and their mothers were tested twice (Time 1/T1 and Time 2/T2) across a 1‐year period. Standardized measures were administered that assessed the children's and mothers' trust beliefs in physicians, the children's quality of life, and children's adherence to prescribed medical regimes (adherence).

Results

Correlations were found between children's trust beliefs in physicians, mothers' trust beliefs in physicians, adherence, and quality of life. Structural equation modelling analyses confirmed that (a) children's trust beliefs in physicians predicted their adherence and quality of life and (b) there were reciprocal predictive relations between the children's and mothers' trust beliefs in physicians.

Conclusions

The findings yield support for the conclusions that (a) trust beliefs in physicians by children with asthma promote their adherence and quality of life and (b) socialization of trust beliefs in physicians is a mutual mother–child process.
Effect of different maintenance time of torque application on detorque values of abutment screws in full‐arch implant‐supported fixed prostheses
Authors: Al‐Otaibi Hanan Nejer , AL‐Fouzan Afnan F. , Al‐Mufleh Tamadher S. , Labban Nawaf
Published: August 2018

Background

The effect of different maintenance time of torque application and screw loosening in full‐arch implant‐supported prosthesis remains uninvestigated.

Purpose

To examine the effect of different maintenance time of torque application on detorque values of implant abutment screw in full‐arch implant‐supported fixed complete denture.

Materials and methods

Passively fitting framework supported by four implants stabilized on resin model torqued to 35 N‐cm and maintained for different times; instant torque application (protocol A), 10 seconds (protocol B), and 30 seconds (protocol C) were used. Detorque values were recorded during removal of the screws. Comparison between mean torque and detorque values were made using paired sample t‐test. The mean removal torque values of each protocol were compared using three‐way analysis of variance (ANOVA).

Results

The mean removal torque values were lower than the applied torque for all the protocols. The highest mean removal torque value was found in the immediate protocol (A) (24.44 ± 1.7), followed by the 30 seconds protocol (C) (23.37 ± 1.75), and then by the 10 seconds protocol (B) (23.35 ± 1.6). All these differences were found to be statistically significant between torque and detorque values (P = .001). However, the differences among detorque values were not statistically significant (P > .05).

Conclusion

The application of 35 N‐cm for different maintenance time of torque application on implant abutment screw did not appear to affect the detorque value in a multiple implant‐supported fixed prosthesis. Maintaining the torque for prolonged time (10 seconds or 30 seconds) was not significantly associated with higher preload than instant torque application in full‐arch implant‐supported prosthesis.
Modelling opportunity: An examination of quadratic effects of adolescent Venezuelan substance use
Authors: Croff Julie M. , Washburn Isaac J. , Cox Ronald B. , Liu Chao
Published: August 2018

Introduction and Aims

Numerous studies have found a linear relationship between an exposure opportunity and age of first drug use. This study further tests this relationship by exploring whether a quadratic exposure opportunity best fits the data on age of first use and whether gender moderates this relationship. That is, is there a peak age in which the transition to use occurs for male compared to female adolescents?

Design and Methods

A sample of 1716 adolescents from 14 public and private schools, representative of two school districts in Caracas, Venezuela, was examined using a zero‐inflated Poisson modelling approach to test for quadratic effects. A series of models were tested for each set of substances (alcohol, tobacco and other drugs) to assess whether a quadratic model has better predictive ability than linear models and to test whether gender moderates the quadratic relationship.

Results

After controlling for common covariates, the quadratic models for alcohol indicated the peak age of transition from an exposure opportunity to use was 10‐years of age in this Venezuelan sample. Gender did not moderate these models suggesting an important move toward gender equality in substance use.

Discussion and Conclusions

Focused efforts on preventing exposure to alcohol use during these windows of rapid transition is likely to have the greatest impact on delaying age of onset, which will reduce the overall prevalence of alcohol related problems among adolescents.
Designing Decisions in the Unknown: A Generative Model
Authors: Le Masson Pascal , Hatchuel Armand , Le Glatin Mario , Weil Benoit
Published: August 2018

This study examines how design theory enables to extend decision‐making logic to the ‘unknown,’ which often appears as the strange territory beyond the rationality of the decision‐maker. We contribute to the foundations of management by making the unknown an actionable notion for the decision‐maker. To this end, we build on the pioneering works in ‘managing in the unknown’ and on design theory to systematically characterize rational forms of action in the unknown. We show that action consists of designing decisions in the unknown and can be organized on the basis of the notion of a ‘decision‐driven design path,’ which is not yet a decision but helps to organize the generation of a better decision‐making situation. Our decision‐design model allows us to identify four archetypes of decision‐driven design paths. They enable us to discuss the variety of known organizational forms that managers can rely on to explore the unknown.
Knowledge and behaviours related to oral health among underserved older adults
Authors: Shedlin Michele G. , Birdsall Stacia B. , Northridge Mary E.
Published: August 2018

Objective

To examine the mouth and body knowledge, beliefs and behaviours of Dominican, Puerto Rican and African American older adults, and their relationships to oral and general health and health care.

Background

In his seminal framework, Handwerker posited that the norms, attitudes and behaviours related to the experience of disease and treatment reflect where patients live and have lived and are seeking and have sought care, along with their webs of social and health relations. This framework guides the analysis for the present study, wherein qualitative data are used to understand mouth and body knowledge, beliefs and behaviours among racial/ethnic minority older adults, ie, why individuals do what they do and what it means to them.

Materials and methods

Focus groups were conducted in Spanish or English with 194 racial/ethnic minority older adults living in northern Manhattan who participated in one of 24 focus group sessions about improving oral health. All groups were digitally audio‐recorded, transcribed and translated into English from Spanish, where apt. Analysis involved the classification of evidence from all datasets, organised to identify patterns and relationships.

Results

Four themes were manifest in the data regarding cultural understandings of the mouth, the body and health: (a) the ageing mouth and its components; (b) the mouth in relation to the body, health and disease; (c) social meanings of the mouth; and (d) care of the ageing mouth.

Conclusion

Underserved older adults from diverse cultural backgrounds understand the importance of their mouths to both their overall health and social lives.
The auditor‐to‐client revolving door: A structured literature review
Authors: Kotb Amr , Halabi Hussein , Elbardan Hany
Published: August 2018

This study analyzes the underexplored research area of audit revolving door (ARD). The analytical framework categorized the reviewed articles by author and article information, citation, research theme, motivational event, jurisdiction, nature of research, regional focus, organizational focus, research method, data analysis, literature focus, and findings. Our analysis highlights that no particular aspect can be held true or generalized about the ARD phenomenon. The ARD literature is USA dominated, organizationally based, and focused on post‐departure issues, employing a quantitative approach with obvious lack of perceptions of stakeholders. We call for more qualitative research that critiques pre‐ and post‐ARD, addressing the “how” and “why” questions, soliciting perceptions of various stakeholders. To frame directions for future research, we refer to three areas: threats, benefits, and safeguards of ARD. Our findings are relevant to research students reviewing the auditing literature to find their own research and to academic auditing researchers looking for appropriate research outlets.
Short‐medium‐long‐term efficacy of interdisciplinary intervention against overweight and obesity: Randomized controlled clinical trial
Authors: Fernández‐Ruiz Virginia E. , Armero‐Barranco David , Paniagua‐Urbano José Antonio , Sole‐Agusti Maria , Ruiz‐Sánchez Alfonso , Gómez‐Marín José
Published: August 2018

Aim

The aim of the study is to evaluate the efficacy of a nurse‐led interdisciplinary programme based on healthy eating, physical exercise, and cognitive behavioural therapy applied to anthropometric and cardiovascular measures, which are related to obesity in short, medium, and long term.

Methods

We conducted a randomised controlled clinical trial with 74 obese and overweight participants (experimental group, n = 37; control group, n = 37). An interdisciplinary programme of 12 months was applied and coordinated by a nurse. Anthropometric and cardiovascular measures were taken at the pretest stage, every 6 months during the programme, and 1 year after it finished.

Results

A beneficial effect was found regarding all anthropometric parameters. Tests for weight (F3;207 = 93.27; P < .001) and body mass index (F3;207 = 89.95; P < .001) indicate efficacy of intervention: The experimental group had a weight loss of 7.2 kg (−8.3%) compared to a 0.9 kg (+1.0%) gained in the control group. Systolic (F3;207 = 37.06; P < .001) and diastolic (F3;216 = 57.31; P < .001) blood pressure improved greatly in the experimental group. Forced vital capacity was also increased (F2;138 = 15.51; P < .001).

Conclusion

The interdisciplinary programme coordinated by nurses improved the health of participants, maintaining long‐term effects.