bluuebunny/crossref_metadata_2025 huggingface dataset:
Only Another Adjective, or Finally a New Functional Post-Ideological Subtype? A Conceptual Analysis of Valence Populism
Authors: Michal Aleš
Published: February 2025

This paper explores the impact of the increasing focus on subtypes of populism on contemporary discussions within the field of political science. In an effort to provide more precise descriptions of emerging political tendencies, scholars have responded by introducing new and other types of ‘populism with adjectives’. Among these original conceptualisations remains a valance populism that fuses the appeals of populism and technocracy, and strategic positionality on the political spectrum. The paper begins by elucidating the development of valence populism’s conceptualisation and presents an analysis drawing from Sartori’s methodologies for conceptual innovation. Subsequently, the study assesses the qualities of the valence populism concept. The paper finds that, while valence populism stands as a promising and innovative concept with positive intrinsic attributes, it operates in the field of concurrent concepts with no significant troubles. We identify essential issues related to resonance and the need for clear differentiation from other concepts, which warrant careful consideration in future studies.
Rancang Bangun Purwarupa Alat Penghitung Uang Logam Otomatis Dengan Sensor Multi Coin Acceptor Berbasis IoT
Authors: Stiyawan Riki , Pramana Rimba Nur Ramadhani , Wiguna I Gede Nova , Jasa Lie , Nugraha I Putu Elba Duta , Rahardjo Pratolo
Published: February 2025

Uang adalah suatu benda yang dapat ditukarkan dengan barang lain, sebagai alat penilaian nilai barang dan dapat disimpan. Ada dua bentuk fisik uang yang masih umum digunakan saat ini, salah satunya adalah uang logam. Menghitung uang logam secara manual juga rawan terhadap kesalahan manusia dan dalam waktu yang lama apabila uang logam dalam jumlah yang banyak. Salah satu solusi yang dapat digunakan adalah dengan merancang bangun alat penghitung uang logam otomatis berbasis IoT. Penelitian ini bertujuan untuk merancang alat penghitung uang logam otomatis berbasis IoT yang dapat membantu menghitung uang logam secara akurat dalam berbagai aplikasi seperti mesin penjual otomatis dan kasir. Alat ini menggunakan sensor multi coin acceptor untuk mendeteksi dan mengidentifikasi berbagai jenis uang logam, dengan board mikrokontroler ESP32 sebagai pengendali utama dan modul komunikasi IoT untuk mengirim data ke server. Perangkat lunak yang dikembangkan memungkinkan data dari sensor diolah dan ditampilkan melalui antarmuka pengguna berbasis web. Hasil pengujian menunjukkan bahwa alat ini mampu mendeteksi dan menghitung uang logam rupiah dengan akurasi 100%, serta memudahkan pengguna dalam memantau jumlah uang yang terkumpul. Penelitian ini berhasil mencapai tujuannya dengan menghasilkan alat yang akurat dan efisien dalam menghitung uang logam dari empat jenis denominasi yang diuji, yaitu Rp100, Rp200, Rp500, dan Rp1000.
Prototipe Alat Monitoring Suhu dan Kelembapan Ruang Baterai pada Gardu Induk Berbasis IoT
Authors: Meunasah Adinda Rahma Satya , Rahmadani Arief
Published: February 2025

Ruangan baterai selalu dijaga tingkat suhu dan kelembapannya agar baterai yang berada didalamnya tidak mengalami degradasi akibat suhu yang tinggi dan sirkulasi udara yang kurang baik. Tujuan dari penelitian ini adalah merancang sebuah sistem yang mampu memantau dan mengontrol suhu serta kelembapan di ruang baterai. Metode yang digunakan yaitu merancang desain mekanik serta elektrik prototipe sistem dan membuat program kontroler, hingga pengujian keseluruhan sistem. Sistem terdiri dari mikrokontroler STM32F103C8T6 dengan menggunakan sensor DHT-22 untuk mengetahui besar suhu dan kelembapan pada ruangan baterai, sensor tegangan untuk mengukur tegangan baterai dan exhaust fan. Hasil pengujian tingkat akurasi error pengukuran nilai suhu sebesar 0,2%, kelembapan sebesar 4,04%, serta tegangan total baterai yang tersimpan dengan rata-rata error 0,5%. Exhaust fan mampu berputar dengan pengaturan duty cycle yang menghasilkan nilai tegangan input sebesar 29.8 V ; 34.88 ; dan 42.88 V, nilai tesebut menyesuaikan dengan standar nilai suhu dan kelembapan didalam ruangan baterai.
Towards a better understanding and monitoring of levees behaviour to mitigate flooding risks
Authors: Cola S
Published: February 2025

Although the river levees have been utilized for land protection by the earliest civilized societies over
4000 years ago, they are becoming increasingly crucial for our safety today. This heightened importance is due to the
industrialization of many regions, which has exponentially increased the value of protected areas. This issue is rapidly
becoming a critical concern in many European countries and beyond, particularly in light of the impacts of global climate
change on regional weather patterns. While both the design of new embankments and the maintenance of existing ones
aim to prevent structural failures, they follow distinct procedures. The challenge of understanding the inner composition
and actual state of conservation of existing structures and their foundations requires comprehensive on-site investigations
and careful surveys. On the other hand, given their extensive length, developing cost-effective strategies and procedure
for rapidly assessing the health state and detecting local anomalies in their geotechnical behaviour is demanding. To
address this challenge, numerous methodologies based on new technologies, such as geophysical tests, remote sensing,
fibre optical-based sensors and deep learning, are continually being proposed and examined. This intervention, while
not an exhaustive review of new approaches, aims to critically illustrate the state-of-art methods for monitoring and site
investigation of river embankments, supplemented with some examples.
Piled raft design of the high-rise building in weak mudstone rocks
Authors: Seo D , Song H , Seo W , Lee J , Jeong S , Park J
Published: February 2025

The design of piled raft foundation was done by using pile loading tests and a numerical analysis.
The emphasis was on quantifying the effectiveness and practicality of the barrettes pile bearing even in weak
rocks. The case of high-rise buildings constructed on weak mudstone rocks was analyzed. Much work has
been carried out through a combination of Osterberg pile loading tests and numerical analyses. In particular,
3D finite element method and beam-column analysis were employed to evaluate the settlement and stability
of the foundation structure. Based on the results obtained, some findings highlight the feasibility and cost-
effectiveness of using optimized piled raft foundations as a practical solution for constructing high-rise buildings
on challenging geological conditions.
Promising ways to raise public awareness of first aid rules
Authors: Stanishevsky A. L.
Published: February 2025

Introduction. The ability of an eyewitness to provide immediate and correct first aid to a victim is a key factor of increasing the chances of a favorable outcome in various life­threatening conditions. Informing the population about the importance of the first aid, teaching the necessary algorithms of these actions, and introducing targeted mobile applications can significantly increase the frequency and quality of the first aid.

The aim of the study is to examine the main sources of information about the first aid and to identify perspective directions for increasing public awareness in this problem.

Materials and methods of the study are based on anonymous questionnaire survey among fuel and energy complex workers of the Republic of Belarus in January­June 2023, which was conducted with the questionnaire «Awareness of First Aid». The survey involved 894 respondents without medical education. The survey helped to determine the coverage of respondents by the first aid trainings, to understand their awareness of the first aid, and to realize the main and prospective sources of information about the first aid. Methods of nonparametric statistics were used to analyze the results.

Results. According to the survey results, 93.5% of respondents are familiar with the basic rules of the first aid; 86,8% were trained; 9.7% studied independently. Additional sources of information about the first aid include visual information — 41.5%, first Aid training publications — 30.6%, social networks — 27.6%, and the information from the social environment — 22.0%. Respondents considered the prioritizing sources of information about first aid, which are included visual agitation (37.1%), smart programs «First aid» (35.6%), handouts (25.6%), unified training manual «First aid» (26.2%), etc. According to the respondents, awareness about first aid could be facilitated by wide media coverage (27.0%), introduction of a compulsory training discipline «First Aid» (18.7%), creation of national digital content about first aid (10.9%), compulsory trainings (9.9%). However, the existing educational publications do not have a unified algorithm of first aid and do not support the motivation to render first aid (only 44.1% of respondents consider themselves as full participants of first aid), it also contains outdated or inadmissible recommendations.

Conclusions. The creation of a unified information environment «First Aid» can be an important option for increasing public awareness of the first aid. This information environment could solve the following problems -like increasing the motivation of population to training the first aid, like unification of this training and like implementation the first aid training through the mobile technologies.
Prospects for the use of intraosseous vascular access in emergency medical care in emergency situations and military conflicts
Authors: Zhirov A. V. , Minnullin I. P. , Radushkevich V. L. , Perevozchikov E. N. , Minnullin I. R. , Dubiy A. O.
Published: February 2025

Based on the analysis of 96 cases of the use of intraosseous vascular access (IVSD) in the Belgorod region, the article assesses the prospects for its use in the provision of emergency medical care in emergency situations and military conflicts. On the basis of our own material, the indications for VCSD, the expediency of mastering a practical skill at the workplace with the help of the KT UVK M simulator were substantiated. Additional advantages of VCSD in the provision of EMS in conditions of a real threat of enemy fire impact are noted, when patients are in armor protection, unloading, and doctors and paramedics use personal protective equipment — bulletproof vests and helmets.
On the prospects for training personnel for the disaster medicine service in the conditions of Russia’s withdrawal from the Bologna agreement
Authors: Suin P. A. , Gumenyuk S. A. , Egorov K. V.
Published: February 2025

Purpose of the study: to assess the effectiveness of training medical personnel in the Russian Federation, taking into account the requirements of the Bologna Declaration, to establish promising directions for reforming the higher education system in medical universities, including in the training of personnel for disaster medicine, after Russia›s withdrawal from the Bologna Agreement.

 Materials and methods. Based on information from scientific thematic sources, an analysis of the results of the reform of higher education in Russia under the influence of the Bologna Declaration was carried out, and promising directions for optimizing higher education in medical universities after leaving it were identified. Historical and analytical methods, methods of comparative analysis and scientific generalization were used.

Results. Under the influence of the Bologna Declaration, by 2013, Russian universities switched to a three-level model of higher education, which required the development of training programs and accreditation of educational programs. From 01.09.2017 internship as the first stage of primary specialization of medical personnel ceased to exist, which significantly reduced the quality of practical training of medical specialists. The training of medical personnel in medical universities in the fields of general medicine, pediatrics, pharmacy, etc. is currently carried out according to educational programs of a six-year specialty and a two-year residency.

Conclusion. In connection with the exit from the Bologna system in 2022, developments are underway in Russia to reform higher education. At this stage, it is advisable to consider the issue of introducing an internship institution in order to train highly qualified medical specialists, including for work as part of non-staff units of the disaster medicine service.
Examination and treatment of patients with shortness of breath in an inpatient emergency department
Authors: Ershov A. L. , Kolomoytseva T. A.
Published: February 2025

The review is devoted to some issues of the pathophysiology of acute dyspnea, its clinical manifestations, approaches to assessing severity, as well as some aspects of laboratory and instrumental diagnostics. Considered the  use  of  oxygen  therapy  and  non-invasive  methods  of  respiratory  support,  which  may be required in the process of providing care to patients with shortness of breath in a hospital emergency department.
Modern portrait of a patient with unstable angina: new trends
Authors: Dadova M. S. , Kostenko V. A. , Skorodumova E. A. , Rysev A. V. , Bakaev I. A. , Siverina A. V. , Skorodumova E. G.
Published: February 2025

The article presents data demonstrated actual situation of the course and long-term prognosis in patients with unstable angina taking into consideration the pathomorphosis of deseasein reperfusion era. Retrospective study was conducted in 316 individuals diagnosed with unstable angina admitted to the Regional Cardiovascular Center of the I. I. Dzhanelidze Research Institute of Emergency Medicine from 2018 to 2022. Long-term results were studied (n=137) after 12 months after primary hospitalization (endpoints: sudden cardiac death, acute cerebrovascular accident, re-hospitalization for acute coronary syndrome, heart failure and paroxysmal atrial fibrillation.
Еfficacy of glucocorticoids in intensive treatment of acute obstructive laryngitis in children: a review
Authors: Bykov Yu. V. , Оbedin A. N. , Zinchenko О. V. , Yatsuk I. V.
Published: February 2025

Goal. To analyze the data of foreign and domestic periodical literature on the aspects of the appointment of glucocorticosteroids (GCs) in acute obstructive laryngitis (АOL) in childhood.

Materials and methods. 33 foreign and domestic sources on the studied problem were considered, including 15 sources over the past 5 years.

Results. According to different authors, the following are considered the mechanisms of action of GC drugs, this paper provides evidence of their therapeutic efficacy, justifying their use as treatment of choice in AOL of any severity grade, in the prehospital as well as hospital settings. The characteristics of a range of different GCs (dexamethasone, prednisolone, budesonide, beclometasone, fluticasone) administered through inhalation and other routes are compared in regard to their use in intensive treatment of AOL in pediatric  practice.

Conclusion. It is advisable to prescribe GCs for AOL in children. A better understanding of the particulars of use of GCs in children with AOL should improve the quality of intensive care in this pathology.
Einführung in die katathym-imaginative Psychotherapie
Authors: Kottje-Birnbacher Leonore
Published: February 2025

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Korelasi Indeks Massa Tubuh dengan Kadar Kolesterol Total pada Mahasiswa Pre Klinik Fakultas Kedokteran Universitas Andalas
Authors: Muhammad Zikra , Julizar Julizar , Suchitra Avit
Published: February 2025

The increase in body mass index is a condition were excessive increase in fat accumulation in adipose tissue so it can be detrimental to health. Increase in lipid metabolism can trigger the increase in cholesterol level inside the body. This study  aimed to know the correlation between body mass index and total cholesterol level on Medical Faculty of Andalas University pre clinic student.
The research method used in this study was an analytic cross sectional approach, conducted from April to December 2020 in Medical Faculty of Andalas University. The subject were 35 pre clinic students who currently in Padang when the research was conducted. The data taken in this research were age, sex, height, weight, and total cholesterol level. The statistical test used was Pearson correlation test.
The result of this research found that p value was 0,173, showed that there was a meaningless relation between BMI and total cholesterol level with negative correlation value (r = -0,236).
This research concludes that there is no correlation between BMI with total cholesterol level on Medical Faculty of Andalas University pre clinic student.
The impact of bring your own device (BYOD) on ergonomics for school-aged children
Authors: Chapman Heath , Kerr Shenaye , Lafferty Emily , Olsen Alyssa , Vanama Preethi
Published: February 2025

This open education resource aims to enable occupational therapists (OTs) and teachers to enhance ergonomic practices for upper primary school students while using Bring Your Own Device (BYOD) devices in school and home contexts.
Fast Numerical Modeling of Propeller–Wing Aerodynamic Interactions
Authors: Nederlof Robert , Goyal Jatinder , Sinnige Tomas , Ragni Daniele , Veldhuis Leo L. M.
Published: February 2025

This paper presents an improved approach for fast numerical modeling of the mutual aerodynamic interactions between a wing and tractor propellers for preliminary design purposes. Vortex methods are used to model the propeller and wing aerodynamic performance. The blade element momentum (BEM) method, which is used to model the propeller performance, is extended to allow for a nonuniform inflow field, such that the upstream effects of the wing can be included in the propeller performance modeling. The circulation distribution over the propeller blades is then used in the slipstream tube model (STM) to determine the time-averaged propeller slipstream velocities. Finally, an improved vortex lattice method (VLM) is used to model the wing’s spanwise lift distribution. The method includes an often overlooked correction for the finite slipstream dimensions experienced by the wing segments, in both vertical extent and spanwise extent. This physics-based correction, based on the image vortex technique, partially offsets the large discrepancies in the lift augmentation found in previous low-order numerical analyses of propeller–wing interactions, while keeping the analysis routine computationally very cheap. The BEM and STM are validated against experimental data, while the VLM and complete propeller–wing system are validated against high-fidelity numerical data, confirming the accuracy of the used models. Discrepancies are found in regions or operating conditions where viscosity becomes more relevant, such as separated flows. The numerical model derived in this paper can be used for a quick and accurate first-order estimation of the aerodynamic performance of new conceptual distributed propeller aircraft.
Novel aspects in blood transfusion – From donor to patient
Authors: Talukdar Biplabendu , Bhattacharya Prasun
Published: February 2025

Blood transfusion is a critical component of modern healthcare system, which is ensured the availability of safe and compatible blood products for patients as when need. This review article explores the entire journey of blood from donor to patient, emphasizing the importance of voluntary non-remunerated repeat blood donation, rigorous donor selection, and advanced laboratory techniques to ensure transfusion safety. It excavates into the challenges of maintaining an adequate blood supply, the ethical considerations in transfusion practices, and the latest advancements in transfusion medicine. In this article, we discuss the indications for blood transfusion, liberal versus restricted transfusion policies, and the management of transfusion reactions. Through comprehensive analysis and practical insights, main aims of this article to enhance the understanding and implementation of blood transfusion services, ultimately improving patient outcomes.
Non-verbal agents of theatrical retranslation: Women’s identity and the Spanish classics
Authors: Braga Riera Jorge
Published: February 2025

Despite the burgeoning interest in literary retranslation, there is still a need to investigate how linguistic, contextual, and personal factors influence the translation of a previously translated (and performed) play into a given target language and culture. This article aims to illuminate the extralinguistic agents (personal, social, performative, paratextual) that specifically intervene in the English retranslation and reception of the Spanish classical play La vida es sueño (Calderón de la Barca, 1636). The focus will be on women’s identity in the source text and how it is transmuted in the target plays, particularly emphasising the empowerment and identity granted to female characters. This is most noticeable in the case of Rosaura, who valiantly seeks revenge on Astolfo to restore her honour. To illustrate this, three performance-oriented retranslations staged in the UK and US between 1983 and 2010 will be scrutinised: John Barton and Adrian Mitchell’s Life’s a dream (1983) José Rivera’s Sueño (1998) and Helen Edmundson’s Life is a dream (2009). Together they demonstrate the relevance of non-verbal agency in the process of retranslating women’s identity. Conclusions will highlight the potential of (Spanish) theatre classics as catalysts for gendered retranslations on the Anglophone stage.
Staging identity: When poets read themselves and their translations
Authors: Cercel Larisa
Published: February 2025

The article deals with a new subject of translatological research: the translator’s own reading, namely the public reading or performance of a translation by the translator themselves. This genre (Cercel 2020) is intimately related to the question of identity, given that the translator presents his or her own translation to the audience. That translation bears the inevitable mark of his or her individuality and moreover involves the affirmation of his or her identity as the author of the translated text. The translation-performance nexus in the translator’s act of reading will be explored in the essay in terms of the parameters of (a), the voice, (b), the public persona and (c), the effect of the performance. Dealing with the phenomenon of ‘voice’ offers direct access to the identity of a translator because “the uniqueness of the person is represented by the voice. The voice is the expression of the person, and more importantly, it is the essence of the person” (Pajević, 2002, p. 240). The term “public persona” goes back to Carl Gustav Jung (1974) and refers to the outwardly displayed attitude of a person that serves as a vehicle for his or her adaptation — or conversely non-adaptation — to social conventions and expectations, and which is closely related to his or her self-image and identity. The “effect” (Fischer-Lichte, 2003) provides information about the audience’s perception of and reaction to the given performance and the translator’s identity statement contained therein. These parameters will be examined on the basis of a historical corpus, namely that of Paul Celan’s readings of his poems and translations.
Spectroelectrochemical properties of 8-aminoquinoline: voltammetric and computational studies
Authors: Wiloch Magdalena , Piekarski Dariusz , Baran Natalia , Kubas Adam , Jönsson-Niedziółka Martin
Published: February 2025

8-Aminoquinoline (8AQ) is the building block for many medicinal molecules. However, the redox properties of 8AQ, which are important for understanding the redox stability of drugs based on 8AQ in the human body, have not been studied in detail before. We have used cyclic voltammetry and pulse voltammetric techniques to investigate the anodic as well as the cathodic electrochemical behaviour of 8AQ in a wide pH range. We have also applied UV-Vis spectroscopy to get a better understanding of the deprotonation of 8AQ due to pH changes. In addition, quantum chemical studies exploring the energy landscapes of the possible oxidations and reductions were performed, advancing our understanding of the electrochemical phenomena. The results indicate that the oxidation pathway of 8AQ strongly depends on the pH of the solution while reduction occurs according to a single pathway.
The effect of polybutadiene chain architectures on the dynamic and mechanical properties of vulcanizates
Authors: Gabryś Jakub
Published: February 2025

Four architectures of polybutadiene polymer were investigated in large amplitude oscilation shear (LAOS) and small-amplitude (SAOS) rheological shear tests. The polybutadiene samples were then subjected to mixing in a laboratory mixer and a vulcanization process. The resulting vulcanizates were subjected to Dynamic Mechanical Analyzer (DMA and mechanical tests in the form of a uniaxial tensile test, and an abrasion test
Analytical derivatives of symmetry-adapted perturbation theory corrections for interaction-induced properties
Authors: Tyrcha Bartosz , Gupta Tarun , Patkowski Konrad , Żuchowski Piotr Szymon
Published: February 2025

A new approach that allows for the calculation of interaction-induced properties exclusively from the properties of monomers is presented. The method is derived in the spirit of the symmetry-adapted perturbation theory (SAPT). The interaction-induced property is presented in the first order of the molecular interaction operator, including the exchange effects. Test calculations of the interaction induced dipole moment were carried out for a number of small nonpolar and polar atomic and molecular dimers. The numerical results show that the analytical first-order corrections proposed in this paper reproduce the finite-field treatment of the first-order corrections of SAPT. Compared to supermolecular approaches, the performance of the finite-field SAPT (up to the second order) constitutes an insightful alternative for calculations of interaction-induced properties.
Rationalized synthetic access to benzimidazoline based n-type dopant precursors
Authors: Pallini Francesca , Garavaglia Giulia , Paoli Gabriele , Mattioli Giuseppe , Porcelli Francesco , Mezzomo Lorenzo , Florenzano Domenico Antonio , Ruffo Riccardo , Sassi Mauro , MATTIELLO SARA
Published: February 2025

1H-benzimidazoline based molecular n-dopant precursors, such as 4-(2,3-Dihydro-1,3-dimethyl-1H-benzimid-azol-2-yl)-N,N-dimethylbenzenamine (N-DMBI-H), enable efficient doping of n-dopable organic semiconductors. Chemical modification of the molecular structure of such compounds proved to be a fundamental tool to tune their properties and doping efficiencies, according to the desired application. Versatile and efficient synthetic strategies, giving access to the widest range of substitution motifs, could help improve the access to known derivatives and enable the preparation of new and improved ones. Literature reports several syn-thetic approaches but due to lack of rationalization and a comprehen-sive analysis, the selection of that best suited for a specific target deriv-ative still mostly relies on a trial and error approach. In this work, we compare the features of the two most popular synthetic strategies in the preparation of a wide variety of benzimidazoline dopants having diverse substitution patterns and electronic features. We thus propose guidelines for the selection of the best synthetic approach depending on the characteristics of the target dopant, known as well as original.
Ligand exchange in TREN-based Cobalt (II) funnel complexes in the solid state
Authors: Nyssen Nicolas , De Leener Gaël , Luhmer Michel , Colasson Benoit , Jabin Ivan , Višnjevac Aleksandar , Reinaud Olivia
Published: February 2025

The coordination of CoII with two calixarene-based TREN [tris(2-aminoethyl)amine] ligands is reported. The two ligands differ for the presence of three anisole groups (in Calix-TRENMe) or three phenol groups (in Calix-TRENH) in the macrocyclic structure surrounding the CoIITREN core. Dicationic complexes were synthesized and fully characterized both in solution and in the solid state. Surprisingly, a crystal-to-crystal transformation led to the substitution of the acetonitrile guest ligand by a pair of H-bonded water molecules. This gave rise to the first example of an X-ray characterized aqua-complex with a CoII center confined in a neutral, 5-coordinate N4(OH2) environment.
Deconvolute the Impact of Microenvironment on Proton-Coupled Electron Transfers at Electrochemical Interfaces
Authors: Xu Yifei , Qiu Yunze , Xiao Hai , Xu Bingjun
Published: February 2025

Microenvironment at electrochemical interfaces has a critical impact on the elec-trode-mediated proton-coupled electron transfer (PCET) processes. However, understanding the convoluted effects by microenivornment remains challenging, and deploying the electron tranfer theory of the Marcus-Hush-Chidsey (MHC) framework is limited by its elusive link to experimentally accessible variables other than reaction rates. Herein, we report a general mech-anistic framework based on the MHC theory to deconvolute the effects of microenvironment on the interfacial PCET processes in terms of experimentally accessible variables, as illustrated by the model system of the cation effect on Au-catalyzed CO2 reduction reaction, for which we rationalize the trends by both inorganic and organic cations in a unified picture formulated by hydration free energy of cation and surface charge density.
Towards automated physics-based absolute drug residence time predictions
Authors: Smith Zachary , Branduardi Davide , Lupyan Dmitry , D'Arrigo Giulia , Tiwary Pratyush , Wang Lingle , Krilov Goran
Published: February 2025

The residence time (τ) of a drug bound to a receptor target is increasingly recognized as a key property to control during ligand-optimization campaigns and provides a useful dimension for modulating compound profiles in addition to binding affinity. For this reason, many computational approaches have been developed to predict this quantity. Several methods employ an empirical correlation between the residence time and the measured simulation time for a ligand to escape the binding pocket during biased molecular dynamics (MD), while others rely on more formal approaches that require a substantially larger computational effort and/or setup times often impractical in a fast-paced drug-discovery setting. Here we propose a new scheme to calculate absolute residence times by using two enhanced sampling approaches, consisting of an exploration phase followed by an exploitation phase that estimates the residence time: Random Acceleration Molecular Dynamics (RAMD) to harvest plausible egress pathways, and then Infrequent Metadynamics (iMetaD) to estimate residence time. This protocol caters to drug discovery programs, where a key aspect is the compromise between accuracy, throughput, and ease of use. We benchmark this approach by computing residence times for a congeneric series of ligands binding to several diverse drug targets and show that we can achieve good accuracy (RMSE of 1.22 and R2 of 0.80 in log10(τ)) without manually tuning the enhanced sampling parameters.
El Impacto del Español en la Industria del Videojuego
Authors: González-Tardón Carlos
Published: February 2025

Esta investigación se enmarca dentro de las acciones del Observatorio Nebrija del Español, en su línea de trabajo del impacto de la lengua en las industrias culturales que se lleva realizando desde el año 2021. Analiza los datos de la industria de videojuegos española y de los países hispanohablantes en Steam entre los años 2020-21 y 2015-16, con el fin de ver el impacto económico de la presencia del idioma español de España y de Latinoamérica. Se han analizado un total de 387 videojuegos publicados en Steam desarrollados en España (268) y en los países hispanoamericanos (119). Los análisis inferenciales indican que los videojuegos que incluyen español de España o ambos tipos de español tienen significativamente más reseñas, venden más y facturan más que los que no incluyen estos idiomas. La industria del videojuego tiene un marcado carácter internacional y es muy importante la estrategia de lingüística para sus empresas. Los datos obtenidos en esta investigación suponen una indicación de la importancia de la presencia del español, tanto de España como el de Latinoamérica, como marcador de aquellos proyectos que van a tener mejores resultados e impacto en un mercado tan exigente como el de Steam.
Research on the Development of Audit Systems in the Sui and Tang Dynasties
Authors: Jing Dongna
Published: February 2025

Look to the past and learn from the past. The Sui and Tang dynasties were the prosperous and developing period of China’s feudal economy, and it was also the period when China’s ancient audit explored and developed in the direction of independence and full-time. Taking the national audit as an example, this paper discusses the evolution, development and progress of the national audit in the Sui and Tang dynasties from the historical perspective, explores the nature and law of the audit, reveals the enlightenment and reference significance of the audit in the Sui and Tang Dynasties to the modern audit, and provides useful ideas and references for the development of the modern audit cause. At the same time, this paper also hopes to take this opportunity with the majority of audit workers and researchers in related fields to think together, and jointly promote the sustainable development and innovation of the audit cause.
Research on the Teaching of Organic Chemistry Theory Courses for Non-Chemistry Majors in Higher Education Institutions
Authors: Du Zhi-Hong , Liu Ning , Chen Fei , Bo Chunbo , Li Min
Published: February 2025

With the development of the era, the teaching achievements and teaching quality of Organic Chemistry theory for non-chemical majors in colleges and universities have been paid more attention by people from all walks of life. Therefore, the theoretical courses in the teaching process need to be adjusted in the trend of interdisciplinary integration to constantly meet the different learning needs of students. This paper mainly starts with the necessity of organic chemistry theory course teaching for non-chemistry majors in colleges and universities, analyzes the current teaching status of organic chemistry theory courses for non-chemistry majors in colleges and universities, and deeply analyzes the teaching path of organic chemistry theory course for non-chemistry majors in colleges and universities, hoping to provide some new teaching ideas for relevant teachers.
Regarding the Evolution of BRM Simulator Training Concept in the Framework of MASS
Authors: He Liang , Shao Guoyu
Published: February 2025

As artificial intelligence (AI) has advanced, there has been a lot of discussion and worry about academic theoretical research on MASS. The concept and facilities of BRM simulator training for MASS will be changed. BRM simulator training serves as a link between nautical theory and practice, which is crucial for the creation of MASS and the specification of MASS. This paper examines and discusses the transformation of BRM “resources” and the fresh requirement for instructor competency. The concept of BRM training for MASS is to change the focus from knowledge, skills, and attitudes to developing managerial competencies for judgment, analysis, and decision-making.
The Future of Artificial Intelligence in Accounting
Authors: Nikiforova N. A.
Published: February 2025

The business landscape is being reshaped by artificial intelligence’s (AI) process automation and data aggregation. The consequence of this change is in accounting, where concerns about the unlimited use of automated processes are widespread. The paper aimed to comprehensively examine current trends and forecasts and to analyze the potential impact of these technologies on various areas of human activity and social processes. AI rapidly advances, offering opportunities for improved production, quality of life, and problem-solving. AI-powered systems can settle complex problems autonomously. Formulating and testing hypotheses, logical reasoning, and content analysis are foundational to major research methods. This allows to accumulate analytical material and review all the information collected during the research. The paper examines AI’s strengths and weaknesses to highlight its similarities and differences in human intelligence. The author explores AI’s history to set the stage for a discussion of its future effects on accounting. Also, the author analyzes these publications to predict the future of accounting in an AI-driven workplace. Artificial intelligence cannot easily replace human qualities. This study’s results, accessible to a broad audience, reveal that AI’s impact on accounting extends beyond automation and efficiency gains to a fundamental reshaping of the accountant’s organizational function. Professionals ready for a rapidly changing digital world will find new opportunities here.
Anti-Racism Education Based on Religious Moderation Values in Pesantren Salaf
Authors: Mustopa Mustopa , Ridwan  , Nasikhin Nasikhin
Published: February 2025

This study aims to analyze the anti-racism education model based on religious moderation values in Pesantren. Using case study qualitative research, data were collected through in-depth interviews, observations, and documentation studies at Pesantren Nasrul Huda, Batang Regency. The data were analyzed using the Miles and Huberman model. The findings in this study show that the anti-racism education model is integrated through four indicators of religious moderation: tolerance, non-violence, adaptive to local culture, and love for the country. First, strengthening the tolerance aspect is realized through cross-cultural discussion programs and batsul masail activities, where santri are invited to understand different beliefs and customs as well as some cases of khilafiah in fiqh. Second, non-violence is taught through conflict resolution training and emotional management through queuing culture and the Qur'an memorization program, which helps students understand the importance of non-violent problem solving. Third, the formation of a person who is adaptive to local culture is strengthened by wayang art activities, cultural workshops, and the introduction of batik culture, such as learning traditional music. Fourth, love for the country is integrated through a program of visits to historical sites or social activities that foster a sense of love and pride in Indonesia. This pattern has succeeded in shaping the personalities of santri who lead to an appreciation of diversity and respect for others. This study contributes to finding an anti-racism education model based on religious moderation values to be applied in various salaf pesantren in Indonesia.
Assessment of the feed additive consisting of Lactiplantibacillus plantarum DSM 16627 for all animal species for the renewal of its authorisation (Microferm Ltd.)
Authors:   EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Villa Roberto Edoardo , Azimonti Giovanna , Bonos Eleftherios , Christensen Henrik , Durjava Mojca , Dusemund Birgit , Gehring Ronette , Glandorf Boet , Kouba Maryline , López‐Alonso Marta , Marcon Francesca , Nebbia Carlo , Pechová Alena , Prieto‐Maradona Miguel , Röhe Ilen , Theodoridou Katerina , Anguita Montserrat , Bozzi Cionci Nicole , Innocenti Matteo L. , Revez Joana
Published: February 2025

Abstract
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the assessment of the application for renewal of the authorisation of a preparation Lactiplantibacillus plantarum DSM 16627 as a technological additive to improve ensiling of fresh plant material for all animal species. The applicant has provided evidence that the additive currently on the market complies with the existing conditions of authorisation. There was no new evidence that would lead the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) to reconsider its previous conclusions for all animal species, consumers and the environment, for which the additive is considered to remain safe. Regarding the user safety, the additive is a preparation containing a microorganism and therefore should be considered a skin and respiratory sensitiser, and any exposure through the skin and respiratory tract is considered a risk. In the absence of data, no conclusion could be drawn on the eye irritation potential of the additive. There is no need for assessing the efficacy of the additive in the context of renewal of the authorisation.
The middle clinoid process, a variation of parasellar region of sphonoid
Authors: Sienicki Jan , Świeciak Wojciech Ziemowit , Klepacki Łukasz
Published: February 2025

Introduction

Middle clinoid process (MCP) is a very important structure in surgeries performed on the parasellar and sellar regions. MCP is a bony eminence located on the body of the sphenoid, posteriorly to the anterior clinoid process and anteriorly to the posterior clinoid process. It becomes clinically important when it reaches the height of at least 1.5 mm. It can form many variations, the most common is the caroticoclinoid foramen.

Aim

To evaluate detailed knowledge, profound understanding of MCP and its role during parasellar region operations.

Case study

During studies at Department of Anatomy, a dry skull specimen projecting bilaterally clinically important MCP was found. This skull belonged to a 60 years old Caucasian male.

Results and discussion

It becomes clinically important when it reaches the height of at least 1.5 mm. The mean height measures 2.59 mm. MCP occurs in about 40% of the population. It can project either unilaterally or bilaterally. No significant differences between age or sex were observed.

Conclusions

Recognition of MCP or its variations on preoperative imaging is crucial for planning endonasal approach in treatment of paraclinoidal ICA aneurysm, pituitary adenomas or clinoidectomies.
Evaluación del Reconocimiento de las Marcas Patrocinadoras “Top of Mind” de un Club Profesional de Fútbol en México
Authors: Escamilla Almaguer Omar , Ceballos Gurrola Oswaldo , Medina Rodríguez Rosa Elena
Published: February 2025

Las marcas patrocinadoras de los equipos de fútbol profesional en México han cobrado una gran relevancia, ya que por un lado promueven la imagen del equipo y por otro, brindan un aporte económico importante que les permite ser más rentables. El objetivo del presente trabajo es evaluar el reconocimiento de las marcas patrocinadoras “Top of mind” de un club profesional de fútbol en México. Se presenta un estudio de tipo descriptivo en una muestra de 404 aficionados que cuentan con el abono del club de fútbol Tigres, de los cuales 269 son hombres y 135 mujeres con diferentes edades y que comprenden desde los 18 hasta los 67 años. Se consideró el reconocimiento de las marcas patrocinadoras Top of mind a través de una encuesta de lápiz y papel. Los resultados muestran que en la primera pregunta dónde se identifican las tres marcas patrocinadoras del uniforme actual del equipo según vaya recordando, se ubica en el segundo nivel (67%) de notoriedad espontanea; en la segunda pregunta de tres marcas patrocinadoras que relacione con su vida cotidiana se ubica en el Top of mind (76.7%), y finalmente, en la tercera pregunta ¿Cuáles otras marcas patrocinan al equipo? se ubicó también en el Top of mind (56.1%). Se concluye que las marcas patrocinadoras en la playera de un equipo profesional de fútbol están presentes en los tres niveles de reconocimiento de marca, lo que significa que tienen un impacto en los aficionados considerando los diferentes perfiles y segmentos seleccionados.
LEADERSHIP IN IT PROJECTS: A CASE STUDY FROM POLISH COMPANY
Authors:   Silesian University of Technology, Faculty of Organization and Management, Podgórska Marzena , Dylnicki Sebastian ,   Silesian University of Technology
Published: February 2025

Purpose: The main goal of the study was to investigate the potential of servant leadership in
increasing the effectiveness of IT project teams and to assess its impact on organizational
culture. In addition, an analysis of leadership styles was conducted according to Hersey and
Blanchard's situational model.
Design/methodology/approach: In-depth interviews were used to assess the potential of
servant leadership in the IT industry, which were conducted among 5 leaders from the
IT industry, while the analysis of leadership styles was conducted based on the LEAD-Self
questionnaires developed by Hersey and Blanchard. The Benedictine model of management
was included as an additional ethical context.
Findings: research results indicate that servant leadership has an impact on increasing the
effectiveness of project teams and organizational culture. This is because it allows the project
goals to harmonize with the needs of the participants, creating a symbiotic arrangement
conducive to the development of both the team and the project. In addition, the LEAD-Self
questionnaire shows that the dominant primary style, which the survey of leaders uses most
often, is a supportive style.
Practical implications: Implications for organizations and leaders are given in the publication.
The most important of them is to promote a supportive style among leaders that fosters effective
and aligned project teams, as well as to implement proven leadership models, such as servant
leadership, that incorporate ethical and moral values into project management.
Originality/value: The publication addresses the issue of servant leadership in IT project
management and additionally considers the situational approach in this context. By doing so,
it influences the expansion of knowledge in the field of human resource management in project
management and emphasizes the importance of the moral and ethical dimensions of leadership
in combination with the situational approach, which constitutes the originality of the study.
MEDICAL FACILITY MANAGEMENT IN THE CONTEXT OF THE COORDINATED MEDICINE MODEL – RESEARCH ASSUMPTIONS
Authors:   Silesian University of Technology, Faculty of Organization and Management, Skowron Krzysztof
Published: February 2025

Purpose: The main purpose of the paper is to present research assumptions on the issues of the
coordinated medicine model and the management of a medical facility. Due to the
comprehensiveness of the topic, the paper is another part of the publication series.
Design/methodology/approach: The paper is based on a theoretical analysis and literature
review.
Findings: The paper describes the main research assumptions.
Research limitations/implications: The content presented here provides an introduction to
undertaking research on the coordinated medicine model.
Practical implications: The considerations presented and references to international
experience provide a basis for further research to identify possible impacts on improving the
availability and quality of health service provision in Poland.
Social implications: Undertaking research based on the theoretical assumptions of the model
described should improve the health of the population and make more rational use of resources
to improve access to services.
Originality/value: The paper is primarily addressed to health care managers, as well as
economists and government employees dealing with management issues in health care and
public health.