bluuebunny/crossref_metadata_2025 huggingface dataset:
Intelligent Control System Design of Ring Light via IOT Mobile Robot
Authors: Kang Xianzhi , Teng Yue
Published: April 2023

In the Internet of Things (IoT) era, the combination of mobile robots and IoT technology has realized the complementary advantages of the IoT and robots, which has brought new challenges and opportunities for the development and application of the IoT and mobile robots. In this study, a mobile robot positioning system based on the wireless positioning technology of the IoT is first designed, and an adaptive federated filtering algorithm based on the confidence of the sensor measurement data is given, and the data fusion processing is carried out for the positioning system to achieve the accurate positioning of the mobile robot. Then, we embed the intelligent control system of the ring lamp and propose an adaptive fuzzy PI double closed loop equalization control strategy, which can automatically identify the number of interlaced parallel and ensure its equalization effect. The experimental results show that the equalization strategy designed in this study has a good equalization effect in the loop interleaving parallel topology, strong adaptive parameter adjustment ability, good robustness, and anti-interference.
A Personalized Learning Path for French Study in Colleges Based on a Big Data Knowledge Map
Authors: Xiao Guangzhi
Published: April 2023

The education industry is gradually improving with the rapid development of information technology. The learners use networks and computers to alter the traditional instructional framework based on educational information technology and achieve personalized learning. This teaching method emphasizes each learner’s identity and autonomy. However, due to the huge number of learning resources available on the Internet, students lack relevant courses, clear learning tasks, and the connection between various knowledge points, resulting in an unsatisfactory effect on the learning process. Knowledge maps for different learner types are created using historical learners’ conceptual knowledge and the segmentation and correlation technique of big data knowledge maps. Using a big data method in this process will automatically generate a set of weak conceptual learning pathways. For this problem, in the era of big data, people put forward the concept of knowledge map and used the algorithm based on the big data knowledge map to study the personalized learning path for college French. The content, structure, and relationship of college French knowledge points can be accurately expressed using this method, which is preferred by college administrators and teachers. This paper aims to investigate the personalized learning path for college French using a big data knowledge map, starting with the characteristics of a college French field of study. This study provides technical support in the establishment of a big data knowledge map based on a learning path recommendation framework. So, after the performance of several commonly used learning path recommendation algorithms, three French students have been selected at random for learning path planning. The results show that personalized learning path planning can be realized based on a knowledge map pre-repair relationship and objective attributes. In the analysis, not only the proposed technique is compared with the conventional optimization approach, but also a comparison study on the benefits of several learning effect prediction models is also performed. The results of this study suggest that this algorithm has a high learning efficiency and that the effective implementation of recommendations produced using our proposed strategy has a significant advantage.
Cesarean Scar Pregnancy and Successful Ultrasound-Guided Removal after Uterine Artery Ligation
Authors: Leanza Vito , Incognito Giosuè Giordano , Gulino Ferdinando Antonio , Tuscano Attilio , Cimino Monia , Palumbo Marco
Published: April 2023

A correct management of cesarean scar pregnancy (CSP) is mandatory to avoid further complications. There is no consensus for the standard therapy and the most frequent methods used are not free from failures and sequelae. A 38-year-old woman was admitted referring amenorrhea lasting 9 weeks, pelvic pain, and vaginal bleeding. She had three previous cesarean sections. Transvaginal ultrasound showed a gestational sac of 16 mm in the cervico-isthmic site and inside the thickness of the uterine wall, and the dosage of beta-human chorionic gonadotropin was 12,770 mU/mL. A diagnosis of CSP was done, and an ultrasound-guided removal after uterine artery cervical branch ligation was performed. The follow-up was uneventful. Even if not yet codified in the literature, our therapeutic procedure should be considered in other similar cases in the future, as it potentially limits the possible iatrogenic problems and reduces intraoperative and postoperative bleeding to a minimum.
Generalized Class of Finite Population Variance in the Presence of Random Nonresponse Using Simulation Approach
Authors: Javed Sapna , Masood Saadia , Shokri Ali
Published: April 2023

In this article, we estimate the finite population variance in random nonresponse using simple random sampling, which may be helpful for data analysis in applied and environmental sciences. For the three distinct random nonresponse techniques by Singh and Joarder [25], we have proposed a generalized class of exponential-type estimators that uses an auxiliary variable. Up to the first order of approximation, expressions of the bias and mean square error of the proposed estimators are obtained. The suggested estimators illustrate their superior performances to the current estimators in the comparable strategies in a comparative analysis using the real and simulated datasets.
Antimicrobial Usage by Small‐Scale Commercial Poultry Farmers in Mid‐Western District of Masindi Uganda: Patterns, Public Health Implications, and Antimicrobial Resistance of E. coli
Authors: Samuel Majalija , Fredrick Wabwire Tony , Tumwine Gabriel , Waiswa Peter
Published: April 2023

Background. Poultry production in Uganda is growing at a fast rate due to increasing demand, notwithstanding, poor husbandry practices, and diseases, prompting farmers to rear healthy productive flocks with antimicrobials. The study evaluated the knowledge and practices as regards the use of antibiotics among poultry farmers in Masindi district and determined the antibiotic susceptibility profiles of E. coli strains from chickens. Methods. A cross‐sectional study using a closed‐end questionnaire was conducted in 140 selected small‐scale commercial poultry farms in Masindi district between June and December, 2020. Analyzed qualitative data were presented as frequencies, percentages, and their 95% confidence intervals (95% CI). Fecal swabs from chickens were inoculated onto a MacConkey agar, and E. coli was confirmed by standard biochemical tests. Antimicrobial susceptibility was determined by the disk diffusion method for 7 antibiotics. Results. Most farmers (74%) used antibiotics, mainly tetracycline (51.4%) and sulfonamides (28.6%), given to the chicks (45%), for both curative and prophylaxis purposes (80%), and via drinking water (67%). Farmers mainly used antibiotics recommended by the veterinarian (76.4%), more than relying on experience (10.7%), while 45% were involved in self‐medicating the birds. On choosing the correct dosage, 45.7% read the instruction, and 42.9% consulted a veterinarian. Only 10.7% observed the drug withdrawal period, while 53.6% consumed eggs at home or sold eggs (35.7%) from birds under treatment. Of the 200 E. coli strains, 90 (45.0%) were resistant to one drug, 74 (37.0%) to two, and multidrug resistance to three classes of antibiotics was 36 (18.0%). Overall, E. coli resistance to tetracycline was (69.0%), ampicillin (37.0%), sulfonamides (36.0%), and to kanamycin (1.5%). Conclusions. The small‐scale poultry farmers frequently use antimicrobial drugs, mainly tetracycline and sulfonamides for curative and prophylaxis. Thus, enforcing measures against antibiotic use supported by a strong veterinary service sector and farmers’ training on judicious use of antimicrobials are needed.
Factors Affecting the Competence Level of Agricultural Extension Agents: A Comprehensive Analysis of Core Competencies in Northwestern Ethiopia
Authors: Aregaw Yosef Getahun , Endris Emam Adem , Bojago Elias
Published: April 2023

The participatory method is supported by the recent expansion of the Ethiopian agricultural extension system through technological scaling-up or the implementation of best practices for technology transfer at larger stages. Agricultural extension workers are active in a number of agricultural and rural development initiatives. This study was a thorough effort that intended to examine the competence level and determinant aspects of the competence development agent’s (DA) level. The investigation was done in the East Gojjam Zone, Northwest Ethiopia. The research included both qualitative and quantitative research designs. Six main skill areas were determined using information from the literature research and the regional state council’s job description for DAs. In this study, 149 DAs from four districts participated as respondents. Ordinal logistic regression analysis was utilized to assess the important parameters influencing DA competency and motivation. According to the mean score findings, DAs performed above average in the communication and program implementation competence categories, with total mean scores of 3.51 and 3.24, respectively. Furthermore, they scored below average in the remaining four competency categories, with information communication technology (ICT) scoring the lowest with a mean score of 1.94. According to the regression model, independent variables such as education level, relationship with coworkers and farmers, supervisor’s visit, and appraisal have a substantial influence on extension agent competency. As a result, competence-specific on-the-job training should be structured to meet the short-term demands of DAs. As the finding suggests, building social capital and investing in education through curriculum development seem more important than interventions to sustain the agricultural extension competencies of DAs. Moreover, digitalizing the extension system could have promising outcomes as most of the DAs are young and their ICT competence has been recorded as higher compared to the older DAs.
Nonlinear Dynamics of a Quantum Cournot Duopoly with Bounded Rationality and Relative Profit Maximization
Authors: Tan Wenhui , Chen Rongsan , Akgul Akif
Published: April 2023

Based on boundary rationality and relative profit maximization, quantum game theory is applied to develop a dynamic model of the quantum Cournot duopoly game. We investigate the effect of quantum properties on game stability and nonlinear dynamics. The results show that quantum entanglement can improve the model’s stability and control the generation of bifurcation and chaos when comparing the classical game and the game without considering relative profit maximization. It facilitates the player’s choice of quantum entanglement to control the chaos that emerges in the production output. Numerical simulations verify the chaotic properties of the game by means of bifurcations, maximum Lyapunov exponents, and phase diagrams. The results show that quantum entanglement has different effects on different games.
Fig. S2 from Small-Molecule–Mediated Stabilization of PP2A Modulates the Homologous Recombination Pathway and Potentiates DNA Damage-Induced Cell Death
Authors: Avelar Rita A. , Armstrong Amy J. , Carvette Gracie , Gupta Riya , Puleo Noah , Colina Jose A. , Joseph Peronne , Sobeck Alexander M. , O'Connor Caitlin M. , Raines Brynne , Gandhi Agharnan , Dziubinski Michele L. , Ma Daniel S. , Resnick Kimberly , Singh Sareena , Zanotti Kristine , Nagel Christa , Waggoner Steven , Thomas Daffyd G. , Skala Stephanie L. , Zhang Junran , Narla Goutham , DiFeo Analisa
Published: April 2023

Fig. S2
Data from Loss of LGR5 through therapy-induced downregulation or gene ablation is associated with resistance and enhanced MET-STAT3 signaling in colorectal cancer cells
Authors: Posey Tressie A. , Jacob Joan , Parkhurst Ashlyn , Subramanian Shraddha , Francisco Liezl E. , Liang Zhengdong , Carmon Kendra S.
Published: April 2023

Abstract
LGR5 is highly expressed in colorectal cancer (CRC) and cancer stem cells that play important roles in tumor initiation, progression, and metastasis. Loss of LGR5 has been shown to enhance therapy resistance. However, the molecular mechanisms that mediate this resistance remain elusive. In this study, we demonstrate conversion of LGR5+ CRC cells to an LGR5- state in response to chemotherapy, LGR5-targeted antibody-drug conjugates (ADCs), or LGR5 gene ablation, led to activation of STAT3. Further investigation revealed increased STAT3 activation occurred a result of increased MET activity. LGR5 overexpression decreased MET-STAT3 activity and sensitized CRC cells to therapy. STAT3 inhibition suppressed MET phosphorylation, while constitutively active STAT3 reduced LGR5 levels and increased MET activity, suggesting a potential feedback mechanism. Combination treatment of MET-STAT3 inhibitors with irinotecan or ADCs substantiated synergistic effects in CRC cells and tumor organoids. In CRC xenografts, STAT3 inhibition combined with irinotecan enhanced tumor growth suppression and prolonged survival. These findings suggest a mechanism by which drug-resistant LGR5- CRC cells acquire a survival advantage through activation of MET-STAT3 and provide rationale for new treatment strategies to target CRC.
Data from Tumor and stromal cell targeting with Nintedanib and Alpelisib overcomes intrinsic bladder cancer resistance
Authors: Marqués Miriam , Corral Sonia , Sánchez-Díaz María , del Pozo Natalia , Martínez de Villarreal Jaime , Schweifer Norbert , Zagorac Ivana , Hilberg Frank , Real Francisco X.
Published: April 2023

Abstract
Bladder cancer is a highly prevalent tumor, requiring the urgent development of novel therapies, especially for locally advanced and metastatic disease. Nintedanib is a potent anti-fibrotic angio-kinase inhibitor, which has shown clinical efficacy in combination with chemotherapy in locally advanced muscle invasive BC patients. Nintedanib inhibits Fibroblast Growth Factor receptors (FGFRs), validated targets in patients with BC harboring FGFR3/2 genetic alterations. Here, we aimed at studying its mechanisms of action to understand therapy resistance, identify markers predictive of response, and improve the design of future clinical trials. We have used a panel of genetically well-characterized human BC cells in order to identify the molecular and transcriptomic changes induced upon treatment with Nintedanib, in vitro and in vivo, at the tumor and stroma cell levels. We showed that BC cells display an intrinsic resistance to Nintedanib treatment in vitro, independently of their FGFR3 status. However, Nintedanib has higher antitumor activity on mouse xenografts. We have identified PI3K activation as a resistance mechanism against Nintedanib in BC and evidenced that the combination of Nintedanib with the PI3K inhibitor Alpelisib has synergistic antitumor activity. Treatment with this combination is associated with cell cycle inhibition at the tumoral and stromal levels and potent non-tumor cell autonomous effects on -smooth muscle (SMA)-positive tumor infiltrating cells and tumor vasculature. The combination of Nintedanib with PI3K inhibitors not only reversed BC resistance to Nintedanib but also enhanced its anti-angiogenic effects.
Supplementary Table S5 from Nucleosome Patterns in Circulating Tumor DNA Reveal Transcriptional Regulation of Advanced Prostate Cancer Phenotypes
Authors: De Sarkar Navonil , Patton Robert D. , Doebley Anna-Lisa , Hanratty Brian , Adil Mohamed , Kreitzman Adam J. , Sarthy Jay F. , Ko Minjeong , Brahma Sandipan , Meers Michael P. , Janssens Derek H. , Ang Lisa S. , Coleman Ilsa M. , Bose Arnab , Dumpit Ruth F. , Lucas Jared M. , Nunez Talina A. , Nguyen Holly M. , McClure Heather M. , Pritchard Colin C. , Schweizer Michael T. , Morrissey Colm , Choudhury Atish D. , Baca Sylvan C. , Berchuck Jacob E. , Freedman Matthew L. , Ahmad Kami , Haffner Michael C. , Montgomery R. Bruce , Corey Eva , Henikoff Steven , Nelson Peter S. , Ha Gavin
Published: April 2023

Unsupervised model predictions and patient/validation cohort sequencing metrics
Sheet 1: DFCI Cohort I: Tumor phenotype by histology and estimates of tumor fraction, subtyping score, and inferred subtype calls using ctdPheno.
Sheet 2: DFCI cohort I: Tumor phenotype by histology and estimates of tumor fraction, subtyping score, and inferred phenotypic subtype calls using different ATAC-seq site restricted analysis using ctdPheno.
Sheet 3: DFCI cohort I: Tumor phenotype by histology and estimates of tumor fraction, subtyping score, and inferred phenotypic subtype calls using different ATAC-seq site restricted analysis using Keraon.
Sheet 4: DFCI Cohort II: Tumor phenotype by histology, summary of clinical correlatives and estimates of tumor fraction, subtyping score, and inferred subtype calls using ctdPheno.
Sheet 5: Histology, tumor fraction, subtype score, NEPC fraction, and subtype calls for WGS and ULP patient samples (UW cohort).
Sheet 6: Complete sequencing metrics for DFCI cohort I.
Sheet 7: Complete sequencing metrics for DFCI cohort II (ULP).
Sheet 8: Complete sequencing metrics for DFCI cohort II (deep WGS)
Sheet 9: Complete sequencing metrics and ichorCNA estimated tumor fractions for the UW cohort (ULP).
Sheet 10: Complete sequencing metrics for the UW cohort (deep WGS)
Sheet 11: Complete sequencing metrics for the healthy donor cohort.
Sheet 12: Clinical data summary for UW cohort.
Supplementary Table S4 from Nucleosome Patterns in Circulating Tumor DNA Reveal Transcriptional Regulation of Advanced Prostate Cancer Phenotypes
Authors: De Sarkar Navonil , Patton Robert D. , Doebley Anna-Lisa , Hanratty Brian , Adil Mohamed , Kreitzman Adam J. , Sarthy Jay F. , Ko Minjeong , Brahma Sandipan , Meers Michael P. , Janssens Derek H. , Ang Lisa S. , Coleman Ilsa M. , Bose Arnab , Dumpit Ruth F. , Lucas Jared M. , Nunez Talina A. , Nguyen Holly M. , McClure Heather M. , Pritchard Colin C. , Schweizer Michael T. , Morrissey Colm , Choudhury Atish D. , Baca Sylvan C. , Berchuck Jacob E. , Freedman Matthew L. , Ahmad Kami , Haffner Michael C. , Montgomery R. Bruce , Corey Eva , Henikoff Steven , Nelson Peter S. , Ha Gavin
Published: April 2023

Feature-region combination AUCs and benchmarking
Sheet 1: Log2 fold-change, p-value, and q-value between ARPC and NEPC lines for central mean coverage in all queried (338) TFs (two tailed Mann-Whitney U test, Benjamini-Hochberg adjusted).
Sheet 2: 100-fold cross-validation AUCs for all region and feature combinations subset by the ‘AR10’ overlapping features (see Methods).
Sheet 3: 100-fold cross-validation AUCs for all region and feature combinations subset by the ‘Phenotype 47-defining’ overlapping features.
Sheet 4: 100-fold cross-validation AUCs for all region and feature combinations (global).
Sheet 5: Predictions scores, tumor fraction, depth of coverage, and subtype for benchmarking admixtures.
Sheet 6: AUCs for unsupervised prediction of admixture subtypes grouped by tumor fraction and depth.
Sheet 7: NEPC:ARPC ratio, tumor fraction, and ARPC and NEPC fraction predictions for mixed phenotype admixtures using Keraon (see Methods).
Table S1 from Addressing Tumor Heterogeneity by Sensitizing Resistant Cancer Cells to T cell–Secreted Cytokines
Authors: Ito Yoshinaga , Pan Deng , Zhang Wubing , Zhang Xixi , Juan Tiffany Y. , Pyrdol Jason W. , Kyrysyuk Oleksandr , Doench John G. , Liu X. Shirley , Wucherpfennig Kai W.
Published: April 2023

Supplementary Table S1: # Raw count of the genome-wide CRISPR screen for identifying T cell-mediated tumor killing in B2m-deficient cells. # MAGeCK results (Gene summary) for the genome-wide CRISPR screen from the B2m-deficient cells. # Gene log2FC in CRISPR screens from B2m-WT cells and B2m-KO cells. ## Common regulators of T cell mediated tumor killing in both B2m-WT and B2m-KO cells
Supplementary Figures from Nucleosome Patterns in Circulating Tumor DNA Reveal Transcriptional Regulation of Advanced Prostate Cancer Phenotypes
Authors: De Sarkar Navonil , Patton Robert D. , Doebley Anna-Lisa , Hanratty Brian , Adil Mohamed , Kreitzman Adam J. , Sarthy Jay F. , Ko Minjeong , Brahma Sandipan , Meers Michael P. , Janssens Derek H. , Ang Lisa S. , Coleman Ilsa M. , Bose Arnab , Dumpit Ruth F. , Lucas Jared M. , Nunez Talina A. , Nguyen Holly M. , McClure Heather M. , Pritchard Colin C. , Schweizer Michael T. , Morrissey Colm , Choudhury Atish D. , Baca Sylvan C. , Berchuck Jacob E. , Freedman Matthew L. , Ahmad Kami , Haffner Michael C. , Montgomery R. Bruce , Corey Eva , Henikoff Steven , Nelson Peter S. , Ha Gavin
Published: April 2023

Supplementary Figures S1-S18 and Supplementary Table legends.
Supplementary Fig. S1 from Addressing Tumor Heterogeneity by Sensitizing Resistant Cancer Cells to T cell–Secreted Cytokines
Authors: Ito Yoshinaga , Pan Deng , Zhang Wubing , Zhang Xixi , Juan Tiffany Y. , Pyrdol Jason W. , Kyrysyuk Oleksandr , Doench John G. , Liu X. Shirley , Wucherpfennig Kai W.
Published: April 2023

Supplementary Fig. S1 shows regulators of MHC-I independent and MHC-I dependent T cell mediated killing.
Table S3 from Abatacept/Ruxolitinib and Screening for Concomitant Respiratory Muscle Failure to Mitigate Fatality of Immune-Checkpoint Inhibitor Myocarditis
Authors: Salem Joe-Elie , Bretagne Marie , Abbar Baptiste , Leonard-Louis Sarah , Ederhy Stéphane , Redheuil Alban , Boussouar Samia , Nguyen Lee S. , Procureur Adrien , Stein Frederic , Fenioux Charlotte , Devos Perrine , Gougis Paul , Dres Martin , Demoule Alexandre , Psimaras Dimitri , Lenglet Timothee , Maisonobe Thierry , De Chambrun Marc Pineton , Hekimian Guillaume , Straus Christian , Gonzalez-Bermejo Jesus , Klatzmann David , Rigolet Aude , Guillaume-Jugnot Perrine , Champtiaux Nicolas , Benveniste Olivier , Weiss Nicolas , Saheb Samir , Rouvier Philippe , Plu Isabelle , Gandjbakhch Estelle , Kerneis Mathieu , Hammoudi Nadjib , Zahr Noel , Llontop Claudia , Morelot-Panzini Capucine , Lehmann Lorenz , Qin Juan , Moslehi Javid J. , Rosenzwajg Michelle , Similowski Thomas , Allenbach Yves
Published: April 2023

Framework for the evaluation of global respiratory muscles and diaphragm function
Table S1 from Abatacept/Ruxolitinib and Screening for Concomitant Respiratory Muscle Failure to Mitigate Fatality of Immune-Checkpoint Inhibitor Myocarditis
Authors: Salem Joe-Elie , Bretagne Marie , Abbar Baptiste , Leonard-Louis Sarah , Ederhy Stéphane , Redheuil Alban , Boussouar Samia , Nguyen Lee S. , Procureur Adrien , Stein Frederic , Fenioux Charlotte , Devos Perrine , Gougis Paul , Dres Martin , Demoule Alexandre , Psimaras Dimitri , Lenglet Timothee , Maisonobe Thierry , De Chambrun Marc Pineton , Hekimian Guillaume , Straus Christian , Gonzalez-Bermejo Jesus , Klatzmann David , Rigolet Aude , Guillaume-Jugnot Perrine , Champtiaux Nicolas , Benveniste Olivier , Weiss Nicolas , Saheb Samir , Rouvier Philippe , Plu Isabelle , Gandjbakhch Estelle , Kerneis Mathieu , Hammoudi Nadjib , Zahr Noel , Llontop Claudia , Morelot-Panzini Capucine , Lehmann Lorenz , Qin Juan , Moslehi Javid J. , Rosenzwajg Michelle , Similowski Thomas , Allenbach Yves
Published: April 2023

Diagnostic certainty criteria for ICI-myocarditis
Supplementary Tables S1-S11 and Figure S1 from Opportunities for Achieving the Cancer Moonshot Goal of a 50% Reduction in Cancer Mortality by 2047
Authors: Shiels Meredith S. , Lipkowitz Stanley , Campos Nicole G. , Schiffman Mark , Schiller John T. , Freedman Neal D. , Berrington de González Amy
Published: April 2023

Supplemental Table 1. 15 leading causes of cancer death in the U.S. in 2019.
Supplemental table 2. Trends in total cancer mortality rates, incidence rates and relative survival in the U.S.
Supplemental table 3. Trends in lung cancer mortality rates, incidence rates and relative survival in the U.S.
Supplemental table 4. Trends in colorectal cancer mortality rates, incidence rates and relative survival in the U.S.
Supplemental table 5. Trends in pancreatic cancer mortality rates, incidence rates and relative survival in the U.S.
Supplemental table 6. Trends in female breast cancer mortality rates, incidence rates and relative survival in the U.S.
Supplemental table 7. Trends in prostate cancer mortality rates, incidence rates and relative survival in the U.S.
Supplemental table 8. Trends in liver/IHBD cancer mortality rates, incidence rates and relative survival in the U.S.
Supplemental table 9. Trends in cancer mortality rates in the U.S., 2000-2019 for selected sites.
Supplemental Table 10. US breast cancer incidence-based mortality*.
Supplemental Table 11. U.S. breast cancer incidence-based mortality by age at death.
Supplemental Figure 1. Liver cancer incidence (1992-2019), survival (2000-2019) and mortality (2000-2019 projected through 2047). This figure excludes cases of intrahepatic bile duct cancer.
Data from Abatacept/Ruxolitinib and Screening for Concomitant Respiratory Muscle Failure to Mitigate Fatality of Immune-Checkpoint Inhibitor Myocarditis
Authors: Salem Joe-Elie , Bretagne Marie , Abbar Baptiste , LEONARD-LOUIS Sarah , Ederhy Stephane , REDHEUIL Alban , BOUSSOUAR Samia , NGUYEN Lee S. , PROCUREUR Adrien , STEIN Frederic , FENIOUX Charlotte , DEVOS Perrine , GOUGIS Paul , DRES Martin , DEMOULE Alexandre , Psimaras Dimitri , LENGLET Timothee , MAISONOBE Thierry , PINETON DE CHAMBRUN Marc , HEKIMIAN Guillaume , STRAUS Christian , GONZALEZ-BERMEJO Jesus , Klatzmann David , RIGOLET Aude , GUILLAUME-JUGNOT Perrine , CHAMPTIAUX Nicolas , BENVENISTE Olivier , WEISS Nicolas , SAHEB Samir , ROUVIER Philippe , PLU Isabelle , GANDJBAKHCH Estelle , KERNEIS Mathieu , HAMMOUDI Nadjib , ZAHR Noel , LLONTOP Claudia , MORELOT-PANZINI Capucine , Lehmann Lorenz , Qin Juan , Moslehi Javid J. , ROSENZWAJG Michelle , SIMILOWSKI Thomas , Allenbach Yves
Published: April 2023

Abstract
Immune-checkpoint-inhibitor (ICI)-associated myotoxicity involves the heart (myocarditis) and skeletal muscles (myositis), which frequently occur concurrently and is highly fatal. We report the results of a strategy that included identification of individuals with severe ICI-myocarditis by also screening for and managing concomitant respiratory muscle involvement with mechanical ventilation, as well as treatment with CTLA4-fusion protein abatacept and the Janus-kinase inhibitor ruxolitinib. Forty cases with definite ICI-myocarditis were included with pathological confirmation of concomitant myositis in the majority of patients. In the first 10 patients, using recommended guidelines, myotoxicity-related fatality occurred in 60%, consistent with historical controls. In the subsequent 30 cases, we instituted systematic screening for respiratory muscle involvement coupled with active ventilation and treatment using ruxolitinib and abatacept. Abatacept dose was adjusted using CD86-receptor occupancy on circulating monocytes. Myotoxicity-related fatality rate was 3.4%(1/30) in these 30 patients vs.60% in 1st quartile(p<0.0001). These clinical results are hypothesis-generating and need further evaluation.
A Novel Biallelic Variant in CDH23 Gene in a Family with Atypical USH1D Manifestation: A Literature Review and Investigation of Genotype-Phenotype Correlation
Authors: Khorram Erfan , Iravani Omid , Khorrami Mehdi , Amini Masoomeh , Jahanian Sara , Nilforoush Mohammad Hossein , Mousavi Seyyed Reza , Ehsanifard Mahsa , Kheirollahi Majid
Published: April 2023

Introduction: Usher syndrome (USH) is an autosomal recessive disorder that predominantly affects hearing, vision, and, in some cases, vestibular function. USH, according to the onset age, severity, and progression of symptoms, is categorized into four main types. In addition, there are a significant number of reports that patients’ manifestations deviate from canonical phenotypic criteria of main types of USH, which are named atypical USH. CDH23 is the second most common USH gene in which its defects result in USH1D, non-syndromic autosomal recessive deafness-12 (DFNB12), and in a few cases, atypical USH1D. While some studies have suggested that missense and truncating damaging variants in the CDH23 gene cause DFNB12 and USH1D, respectively, no genotype-phenotype correlation for atypical USH1D has been established. Methods: Using whole-exome sequencing, we studied an Iranian family with two affected siblings who manifested congenital bilateral hearing loss, late-onset nyctalopia, retinitis pigmentosa, and normal vestibular function, indicating that their clinical symptoms are consistent with USH2. Results: Whole-exome data analysis revealed a novel bi-allelic nonsense variant (c.6562G>T; p.Glu2188Ter) in the CDH23 gene, which was confirmed by Sanger sequencing. Surprisingly, CDH23 is a member of the USH1 genes; therefore, our patients suffered from atypical USH1D. Also, by conducting a literature review, we provided a clinical and mutational profile of all reported patients with atypical manifestations or those who refuted the claimed genotype-phenotype correlation. Conclusion: By reporting a novel damaging variant, we expand the mutational spectrum of the CDH23 gene that leads to atypical USH1D. Also, reviewing the literature shows that, contrary to previous claims, different genotypes occur in the CDH23 gene allelic disorders, and there is no clear-cut genotype-phenotype correlation.
Prognostic Value of Somatostatin Receptor-Derived Volumetric Parameters from a Hybrid Standardized Uptake Value Thresholding Method in Patients with 68Ga-DOTATATE-Avid Stage IV Neuroendocrine Neoplasms: A Preliminary Study
Authors: Cheng Zhaoting , Zou Sijuan , Zhou Jianyuan , Song Shuang , Zhu Yuankai , Zhao Jun , Zhu Xiaohua
Published: April 2023

Introduction: The ability of PET/CT imaging to delineate neuroendocrine neoplasms (NENs) and predict prognosis in affected patients is often compromised by substantial uptake heterogeneity. We hereby proposed a hybrid standardized uptake value (SUV) thresholding algorithm to extract volumetric parameters from somatostatin receptor (SSTR) PET/CT imaging and investigate their prognostic performance in patients with 68Ga-DOTATATE-avid stage IV NENs. Methods: For 38 retrospectively enrolled patients, we used either fixed SUV thresholding of normal liver parenchyma (method A), 41% of the SUVmax for each lesion (method B), or a hybrid method (method A for liver metastases; fixed SUV threshold of normal bone for bone metastases; method B for primary tumors and other metastases) to quantify the whole-body SSTR-expressing tumor volume (SRETVwb) and total lesion SSTR expression (TLSREwb). Patient survival was also recorded and analyzed. Results: PET/CT images revealed heterogeneous uptake of 68Ga-DOTATATE at primary and metastatic sites. Progression-free survival (PFS) and overall survival (OS) were negatively correlated with the extent of liver or bone metastases (p < 0.05), but not significantly correlated with tumor grade or 18F-FDG PET/CT positivity. By the hybrid method, PFS was significantly shorter in patients with high SRETVwb, and OS was significantly shorter in those with high SRETVwb and TLSREwb (p < 0.05). However, when derived from method A or method B, neither SRETVwb nor TLSREwb could predict patient outcomes. Conclusion: Compared with other methods used in 68Ga-DOTATATE-avid stage IV NENs, our hybrid SUV thresholding method demonstrated robustness, with greater precision, reliability, and prognostic power.
Stubborn Predictions in Primary Visual Cortex
Authors: Yon Daniel , Thomas Emily R. , Gilbert Sam J. , de Lange Floris P. , Kok Peter , Press Clare
Published: April 2023

Perceivers can use past experiences to make sense of ambiguous sensory signals. However, this may be inappropriate when the world changes and past experiences no longer predict what the future holds. Optimal learning models propose that observers decide whether to stick with or update their predictions by tracking the uncertainty or “precision” of their expectations. However, contrasting theories of prediction have argued that we are prone to misestimate uncertainty—leading to stubborn predictions that are difficult to dislodge. To compare these possibilities, we had participants learn novel perceptual predictions before using fMRI to record visual brain activity when predictive contingencies were disrupted—meaning that previously “expected” events became objectively improbable. Multivariate pattern analyses revealed that expected events continued to be decoded with greater fidelity from primary visual cortex, despite marked changes in the statistical structure of the environment, which rendered these expectations no longer valid. These results suggest that our perceptual systems do indeed form stubborn predictions even from short periods of learning—and more generally suggest that top–down expectations have the potential to help or hinder perceptual inference in bounded minds like ours.
River Transport and the Effectiveness of the Qing Artillery Corps during the Ming-Qing Transition
Authors: Chung Yan Hon Michael
Published: April 2023

This study examines how the availability of river transportation routes affected the effectiveness of the Qing artillery corps. The Yangzi River system and the Pearl River system guaranteed timely and stable artillery support for the Qing siege force in Jiangnan and Liangguang respectively. This was made possible by the Qing’s large reserves of cannons and the sizeable water forces at several strategically important cities along the two rivers, which constituted a river-based artillery logistic system. In the mountainous and unpopulated areas of China, however, the Qing artillery corps faced considerable logistic difficulties. This put the besieging army in a strategic dilemma, i.e., whether to wait for the siege train indefinitely or to assault the city with cold weapons. To push further, this strategic dilemma posed by the terrain may explain why the Qing army, despite possessing the latest artillery technology, continued using cold weapons extensively until the nineteenth century.
Why I like to be a Role Model of Faith and Yet am Afraid of It
Authors: Baumann Monika , Dreyer Jaco S
Published: April 2023

This article dealt with the experience of full-time youth leaders in Evangelical and Free churches in Germany of their role as role models of faith. The research was based on a qualitative, empirical study in which 12 youth leaders were interviewed, using semi-structured interviews. The evaluation was carried out by doing a category-based qualitative content analysis according to Mayring (2015) and Kuckartz (2018), and the type construction (Kelle & Kluge 1999). The quality of experience of the interviewees in their role as role models was determined. Thus, a differentiated perception of the professional group can be strengthened, and holistic education and training programmes supported.
A Critical Case Study on the Implementation of Computational Thinking in Mathematics Education
Authors: Elicer Raimundo , Tamborg Andreas Lindenskov
Published: April 2023

We report the critical case of an expert teacher, with whom we codesigned, implemented and discussed an innovation consisting of a task addressing a dual learning goals that uses block programming in a geometry lesson for her sixth-grade class. We analyse the case focusing on three sub-processes of implementation. First, the teacher constructs agency over both the structure and content of the innovation, illustrated by altering the sequencing within the task and adding of an open-ended activity. Second, her practice changes to adapt the innovation by bringing her expertise in programming and mathematics teaching to guide the solution of one hybrid task. Third, the innovation is adapted to accommodate her pedagogical approach and push for appealing to students’ personal interests. Despite the realisation of these sub-processes, the outcomes of the realised innovation were not necessarily positive, implying a need for an integrated — not compound — expertise in computational and mathematics teaching.

The impact sheet to this article can be accessed at 10.6084/m9.figshare.22339588.
A new species of Hamodes Guenée, 1852 (Lepidoptera: Erebidae) from China
Authors: ZHANG YU-LONG , WEI FUHONG , FAN XIAOLING , WANG MIN
Published: April 2023

A new species of the genus Hamodes Guenée, 1852, Hamodes zhipengi sp. nov. is described and illustrated from China. The species resembles H. pseudobutleri Wei & Wang, 2019 but differs in wings ground colour; and male genitalia with differently shaped valvae, ampullae and armature of vesica. DNA barcode of the new species and relatives are deposited in GenBank. The holotype is deposited in the Department of Entomology, College of Plant Protection, South China Agricultural University, Guangzhou.
The lost vent gastropod species of Lothar A. Beck
Authors: CHEN CHONG , SIGWART JULIA D.
Published: April 2023

Deep-sea hydrothermal vents host many endemic species adapted to these chemosynthesis-based ecosystems. The exploration of vent fields including those in the tropical Pacific is currently accelerating, due to the development of deep-sea mining for valuable minerals. Molecular evidence has shown that many vent endemic gastropod lineages include sibling species pairs in adjacent oceanic basins. While the fauna of the Manus Basin is relatively well described, many lineages in adjacent regions in North Fiji or Lau Basins are recognised as separate species, but unnamed. Valuable material from this fauna was studied by Lothar A. Beck in the 1990s, who fully drafted descriptions for these species, but did not publish them. Beck’s manuscript names, prior to the present study, represented real species but nomina nuda without taxonomic validity. Here we present the descriptions of seven new species and one new genus, extracted from Beck’s unpublished manuscript that was rediscovered after his death in 2020. The publication of these descriptions makes them taxonomically available and respects the scientific contributions of Beck. Providing valid descriptions of these species is critically important now to enable the recognition of species that may require conservation in the face of future environmental destruction.Symmetriapelta Beck, gen. nov. is described as new genus. Bathyacmaea nadinae Beck, sp. nov., Pyropelta ovalis Beck, sp. nov., Pseudorimula leisei Beck, sp. nov., Lepetodrilus fijiensis Beck, sp. nov., Shinkailepas conspira Beck, sp. nov., Symmetromphalus mcleani Beck, sp. nov. and Symmetriapelta wareni Beck, sp. nov. are introduced as new species.
A new fossil subspecies of booby (Aves, Sulidae: Papasula) from Mauritius and Rodrigues, Mascarene Islands, with notes on P. abbotti from Assumption Island
Authors: HUME JULIAN P.
Published: April 2023

A new subspecies of Papasula booby is described from fossil remains collected in the Mascarene Islands of Mauritius and Rodrigues, southwestern Indian Ocean. The Mascarene Booby Papasula abbotti nelsoni ssp. nov., larger than nominate Abbott’s Booby P. a. abbotti from Christmas Island, northeast Indian Ocean, was approximately the same size as the extinct Hiva Oa Booby P. a. costelloi from the Marquesas in the Eastern Pacific. Mentioned in early accounts of Mauritius in 1668 and in 1725–26 and 1761 on Rodrigues, the Mascarene booby became extinct by the end of the 18th century. Members of another isolated but now extirpated population of Papasula abbotti from Assumption Island in the Seychelles Archipelago, the island from which the type specimen was collected, are identical to extant Christmas Island birds in size and colouration and discussed in detail herein.
Exploring the Existential Implications of COVID-19 in Health Communication
Authors: Harvell-Bowman Lindsey A
Published: April 2023

The coronavirus disease 2019 (COVID-19) pandemic provided an existential threat the world has rarely seen and forced Americans to make meaning in a world of uncertainty surrounding what most have taken for granted, being healthy. Reviewing data from several studies collected throughout the COVID-19 pandemic, this article uses COVID-19 as a case study to understand reasoning to follow (or not) the recommendations set forth by government agencies through understanding the effects of longitudinal death salience (i.e., long-term awareness of death). The Terror Management Health Model (TMHM) argues that death is a key component to the condition of human behavior to elongate life. If the TMHM is correct, then Americans should have widely followed government recommendations, but instead violence and a polarized America ensued. Implications for health communication and the TMHM are discussed, providing a path forward for health communication and existential psychology scholars.
Achieving sustainable development through developmental states in the 21st century
Authors: Haque M. Shamsul
Published: April 2023

This paper explores the growing significance of sustainable development evident in recent global concerns for the worsening conditions of environmental degradation and natural disasters. Despite the massive proliferation of international conventions, regional agreements, and national–local initiatives and the creation of numerous institutions at all levels, there are relatively disappointing outcomes regarding environmental sustainability. Next, the paper examines the main causes of such environmental underperformance, highlights the needs for making appropriate institutional choices, and emphasizes the central role of the state as the leading stakeholder in dealing with environmental governance. Finally, among the major formations of the state, it draws attention to the comparative advantages of the developmental state in terms of its composition, autonomy, embeddedness, and capacity and highlights its potential for more effective performance to achieve sustainable development.
On the understanding and prediction of tribological properties of Al-TiO2 nanocomposites using artificial neural network
Authors: Najjar Ismail , Sadoun Ayman , Fathy Adel
Published: April 2023

Due to the influence of the manufacturing process on the composite’s wear properties, mathematical models cannot accurately predict the wear rates and coefficients of friction of composite materials. As a result, this work provides a deeper comprehension of the tribological properties of Al-TiO2 nanocomposites with varying TiO2 content tested at varying sliding loads as well as improved predictability. Accumulative roll bonding (ARB) was used to create Al-TiO2 nanocomposites that had good TiO2 nanoparticle dispersion in the matrix. The pin-on-disc test was used to measure their wear rates and coefficient of friction. A neural network model was used to predict the wear rates and the coefficient of friction because there was a correlation between the composite morphology, hardness, and microstructure, as well as the evolution of the tribological properties. Due to the uniform distribution of TiO2 nanoparticles within the composite and the saturation of grain refinement in the Al matrix, it was experimentally demonstrated that wear rates decrease as the number of ARB passes increases until a plateau is reached. After five ARB passes, the composite containing 3% TiO2 nanoparticles achieved the maximum hardness improvement of 153.7%. While the same composite’s wear rates decrease from 3.7 × 10−3 g/m for pure Al to 1.1 × 10−3 g/m at 5 N load. For each of the produced composites that were subjected to four distinct wear loads, the artificial neural network model was able to accurately predict the wear rates and coefficient of friction, achieving determination coefficient R2 values of 0.9766 and 0.9866, respectively, for the wear rates and coefficient of friction.
Mechanistic Insights into Bioengineered Antibiofilm Enamel Pellicles
Authors: Moussa D.G. , Kung R.W. , Tse J.S. , Siqueira W.L.
Published: April 2023

Dental caries remains the most widespread chronic disease worldwide. Basically, caries originates within biofilms accumulated on dental enamel. Despite the nonrenewable nature of the enamel tissue, targeted preventive strategies are still very limited. We previously introduced customized multifunctional proteinaceous pellicles (coatings) for controlling bacterial attachment and subsequent biofilm succession. Stemmed from our whole proteome/peptidome analysis of the in vivo acquired enamel pellicle, we designed these pellicles using hybrid mixtures of the most abundant and complementary-acting antimicrobial and antifouling proteins/peptides for synergetic suppression of early biofilms. In conjugating these domains synthetically, their bioinhibitory efficacy was remarkably boosted. Herein, we sought to explore the key structure-function relationship of these potent de novo hybridized conjugates in comparison with their individual domains, solely or in physical mixtures. Specifically, we interrelated the following facets: physicochemical and 3-dimensional folding characteristics via molecular dynamics simulations, adopted secondary structure by circular dichroism, immobilization capacity on enamel through high–spatial resolution multiphoton microscopy, and biofilm suppression potency. Our data showed consistent associations among the increased preference for protein folding structures, α-helix content, and enamel-immobilization capacity; all were inversely correlated with the attached bioburden. The expressed phenotypes could be explained by the adopted strongly amphipathic helical conformation upon conjugation, mediated by the highly anionic and acidic N-terminal pentapeptide shared region/motif for enhanced immobilization on enamel. In conclusion, conjugating bioactive proteins/peptides is a novel translational approach to engineer robust antibiofilm pellicles for caries prevention. The adopted α-helical conformation is key to enhance the antibiofilm efficacy and immobilization capacity on enamel that are promoted by certain physicochemical properties of the constituent domains. These data are valuable for bioengineering versatile therapeutics to prevent/arrest dental caries, a condition that otherwise requires invasive treatments with substantial health care expenditures.
Bias mitigation in empirical peace and conflict studies: A short primer on posttreatment variables
Authors: Dworschak Christoph
Published: April 2023

Posttreatment variables are covariates that are preceded by the main explanatory variable. Their inclusion in a statistical model does not ‘control’ for their influence on the relationship of interest, and it does not substitute for a mediation analysis. Likewise, a coefficient estimate of an appropriate ‘control variable’ cannot be interpreted as a causal effect estimate. While these facts are well-established in various fields across the social sciences, their recognition in the field of peace and conflict studies is more limited. Originally collected data on recent publications from leading peace and conflict journals reveal that a large majority of evaluated articles condition on posttreatment variables, demonstrating how a review of these fallacies can help to substantially improve future research on peace and conflict. Drawing on a broad set of literature and using graphical approaches, I offer an intuitive explanation of the logic of posttreatment variables and clarify common misconceptions. Building on recent developments in methodology and software, and by deriving conditions for bounding using analytical bias expressions, I discuss avenues for dealing with posttreatment variables in observational studies. The article concludes with a discussion of implications for applied research.