bluuebunny/crossref_metadata_2025 huggingface dataset:
DETERMINATION OF THE COORDINATES OF THE SPATIAL ORIENTATION OF THE MAGNETOPLAN REGARDING THE RAIL STRUCTURE
Authors: Holota O. , Plaksin S. , Shkil Y.
Published: January 2023

The article proposes a way to determine the position of the crew of the tape recorder using the method of rangefinder. The basis of the developed idea is the use of emitters with which you can register the rotational movements of the crew (pitch and dredging), as well as to register the roll. According to the results of the research, the following is substantiated: phase rangefinder with one emitter on the crew platform allows to determine the position of the crew on the race, its displacement in the horizontal plane relative to the longitudinal axis of the track structure and the height of the suspension between the crew bottom and three rotational movements (pitch, digging and roll). The novelty of the work is to substantiate the method of continuous positioning of high-speed magnetic levitation vehicle on 6 degrees of freedom based on phase rangefinder for arbitrary configuration in three-dimensional space of a fixed overpass and the integrity of the navigation system. The considered method of navigation is intended for use in high-speed transport ground systems on a magnetic suspension, the organization of the automated control of movement of wheeled transport on local platforms of industrial function, the organization of high-speed small-scale municipal transport of individual use.
Projeto roda de leitura com alunos do 1º ano do ensino médio nos diversos contextos sociais
Authors: Ramos Ivane Câmara Brandão , Silva Jose Amauri Siqueira da
Published: January 2023

É função essencial da escola, ensinar e estimular a leitura, de modo que se amplie o domínio dos níveis de leitura e escrita dos alunos, para assim, formá-los cidadãos críticos. Assim, a problematização deste artigo é: Como se dá o interesse pela leitura através da Metodologia Roda de leitura, na Escola Estadual Dom Milton, da cidade de Manaus-AM, na formação de leitores do 1º ano Médio? De tal modo, tem-se como objetivo: analisar de que forma o letramento social pode contribuir para a capacidade de leitura e escrita dos alunos leitores do 1ºano do Ensino Médio, da Escola Estadual Dom Milton, da cidade de Manaus-AM, no ano de 2019. Para tanto, sob a luz da metodologia quali-quantitativa, foi realizado um estudo de caso com 120 alunos, em 2019, com o desenvolvimento do projeto roda de leitura em sala de aula, na referida escola. Após a realização da Roda de Leitura, notou-se uma melhora muito significativa no gosto pela leitura e também na decifração dos textos, por parte dos alunos. E ao dominar a leitura, abriu-se a possibilidade para adquirir novos conhecimentos, desenvolver raciocínios, alargar a visão de mundo, do outro e de si mesmo, e ainda participar ativamente da vida social, alcançando-se desta forma o Letramento social. Conclui-se que o projeto contribuiu para a visão de mundo dos alunos, formando-os leitores letrados, e ainda mudou o olhar da professora-pesquisadora, abrindo novos horizontes e contribuindo para sua prática enquanto educadora e pesquisadora.
Procedimiento de costos basados en actividades para la fabricación de paneles fotovoltaicos en Cuba
Authors:   Universidad de Pinar del Río, Rojas Hernández Dairon , Pavón Bencomo Ismael ,   Empresa de Suministro Agropecuario Pinar del Río, Pelegrín Mesa Arístides ,   Universidad de Guadalajara, Menoya Zayas Sandys ,   Universidad de Pinar del Río
Published: January 2023

El trabajo realizado se encuentra dentro de los problemas a resolver en la contabili-dad de costos; se persiguió como finalidad el diseño de un procedimiento de costos basado en actividades (aBc) para producir paneles fotovoltaicos, y lleve a un análisis en las decisiones que conduzcan a considerar un cambio en la mentalidad de la direc-ción de la empresa. Se mostraron resultados que parten de una concepción teórica y metodológica para el estudio del crecimiento y desarrollo de actividades que trans-forman e inducen valor, con el fin de obtener mejores niveles de eficiencia y eficacia en la entidad. Se comprobó el desconocimiento de integración de cada una de las actividades que añaden valor en el proceso de creación de paneles fotovoltaicos y el desaprovechamiento de las potencialidades de los trabajadores vinculados a esta acti-vidad, elementos relevantes para impulsar el desarrollo de nuevas formas de gestión.
Impact of Total Quality Management Practices on Customer Satisfaction: Perspectives of Medical Device Company
Authors: Shaibun Juliana , Anuar Herman Shah
Published: January 2023

Customer satisfaction is an asset that should be protected and retained just like any other asset in an organization. The management needs practices that promote customer satisfaction in an organization's service provision. The study objective was to determine the effect of Total Quality Management (TQM) practices in medical device companies in Malaysia on customer satisfaction. This research aimed to establish quality management practices among Malaysia's medical device manufacturing industries and determine their influence on customer satisfaction. The study involved a descriptive overview that undertook a cross-sectional survey design to establish the TQM practices and customer satisfaction in several medical device companies in Malaysia. The study population was employees from various divisions and positions in the medical device industry. Qualitative research methodology has been applied due to the large number of respondents who participated. Data was captured through the interview process and research questionnaire to evaluate the respondents focusing on quality control activities and customer satisfaction in the medical device industry. This qualitative analysis was employed to help this study which seeks to identify cause and effect relationships. Further studies may embark on a larger scale of respondents to better overview the current practices in medical device companies.
Analysis of thermal runaway propagation characteristics of lithium-ion battery module under local high temperature
Authors: Hu Tong , Ma Fei , Xu Xiaoming
Published: January 2023

Lithium-ion batteries are increasingly used in the field of new energy vehicles. Thermal runaway is the biggest potential safety hazard. In order to achieve safer battery design, it is necessary to fully understand thermal runaway. In this research, the thermal abuse model of lithium-ion battery module is established. Temperature propagation characteristics of lithiumion battery pack under high temperature heat source is discussed and analyzed. The results show that there is consistency in the thermal runaway of lithium-ion battery at different surface heat source temperatures, and the thermal runaway of lithium-ion battery packs occurs at 453 K. The location of surface heat source only affects the distribution of temperature when thermal runaway occurs. The smaller the thermal conductivity of the battery spacer layer, the slower the temperature propagation when the battery is out of control.
Modeling thermodynamic properties of Ni, Sn, Al and Cu nanosolids
Authors: Singh Madan , Taele Benedict M. , Lara Sekhantso , Singhal Sanjay Kumar , Devlal Kamal
Published: January 2023

Surface atoms and dangling bonds on the surface affect the thermodynamic properties. A thermodynamical model, based on cohesive energy is presented to discuss the melting properties of materials at nanoscale. The model is used to realize the effect of size and shape on melting temperature Tmn, melting entropy Smn and enthalpy Hmn of Ni, Sn, Al and Cu metallic nanoparticles. The variation in Tmn, Smn and Hmn are examined for nanowire, film, spherical, regular tetrahedral, hexahedral and octahedral shaped nanoparticles. It is reported that Tmn, Smn and Hmn decrease with decreasing the size of the nanoparticles and smaller the particle size, greater are the size and shape effects and when size is less than 10 nm, it has been predicted that on decreasing size, Tmn, Smn and Hmn reduce appreciably. Also, at the same size, more the shape of nanoparticles departs from that of the sphere, smaller is the Smn and Hmn of nanoparticles and its changes are less for nanowire shape and more for regular tetrahedral shape. Our theoretical results are compared with the available experimental or simulation data. Results predicted by our model are in good agreement with experimental observations.
Manuscript Map of Illyricum, 1663, in the Pontifical Croatian College of St Jerome
Authors: Faričić Josip , Marelić Tome , Dundović Zdenko
Published: January 2023

In the Pontifical Croatian College of St. Jerome in Rome, a manuscript geographic map of Illyricum is kept, drawn in 1663 by the architect and geographer, Pietro Andrea Buffalini of Rome. Cartographic analysis of this map has been carried out on several occasions, and the ecclesiastico-legal and historico-geographic context of its origin analysed. As contribution to previous research on the 1663 map of Illyricum, the depiction of the coast on that map is cartometrically compared with that on geographic maps and nautical charts from the late 16th century and the first half of the 17th. On the basis of these analyses it is confirmed that, with the 1663 map of Illyricum, a qualitative step forward was taken in depicting the northeast coast of the Adriatic. In addition, on the basis of research into available written data sources, it is concluded that Ivan Lučić made a key (co)authorial contribution to the shaping of the geographic content of this manuscript map.
A Low-Distortion Map of the World Ocean Without Discontinuities
Authors: Kerkovits Krisztián
Published: January 2023

Ocean maps are rarely in the scope of current studies on minimum-distortion map projec-tions. This study aims to create an uninterrupted map projection to display planet Earth as the Blue Planet: the aspect of the projection is rotated into the middle of the water surface; favourable map distortions are optimized numerically across the World Ocean. The paper starts with a short overview of existing similar projections. In the next pages, the reader may find the detailed description on the development of the new mapping. The paper concludes with maps and distortion analysis in the proposed projection and thoughts about its potential usefulness.
From Map Projection to Semiotics
Authors: Livieratos Evangelos
Published: January 2023

Umberto Eco’s admiration for Charles S. Peirce (1839-1914) for ... earning a living by drawing maps ... combined with the pleasure of knowledge given by the diving to the history of our cartographic discipline, reminded me of a relevant sixty-year-old text about the great scientist and authentic thinker – maybe the greatest of Logic of his time. It is based on unpublished (until then) manuscript material, in his collection of the same name in the Houghton Library at Harvard. The sixty-year-old mathematician Carolyn Eisele (1902−2000) – devoted scholar of Peirce’s work – wrote the text in the early 1960s; it was then published in the Proceedings of the American Philosophical Society. The subject of her text is the problem of cartographic projection. But what can a cartographic projection problem have to do with logic and its practical applications, which is the greatest challenge to Peirce’s thinking?
The Island of Korčula on Early Modern Maps
Authors: Mirošević Lena , Faričić Josip
Published: January 2023

Based on selected cartographic depictions of Korčula from the early modern age, the paper examines the geographical knowledge about that island at the time the maps were made. Special attention is directed to the hitherto unknown map of the island of Korčula from the second half of the 16th or the first half of the 17th century, which is kept in the Archivio do Stato di Venezia, given that it shows a very detailed escription of the island of Korčula, especially its western part. The objective of this paper, using the example of the island of Korčula, is to point out the importance of cartographic renderings as an important source of spatial data and to determine whether there was a gradual improvement in the quality of the displayed geographical content in accordance with the assumed development of geographical knowledge and cartographic techniques from the beginning of the 16th century to the end of the 18th century. On the basis of the selected cartographic depictions of the island of Korčula, the significance of the island of Korčula in maritime and geographic frameworks characterized by different political interests, primarily that of Venice, was confirmed. The diachronic series of early modern geographical maps and nautical charts points to the gradual development of geographical knowledge about the island of Korčula, as well as to the improvement of the quality of graphical visualization of the relevant spatial data about that Croatian island.
Teaching and Learning Process of Pancasila and Citizenship Education Subjects: A Case of SMKN 5 Mataram, Indonesia
Authors: Alqadri Bagdawansyah , Dahlan  , Kurniawansyah Edy , Rispawati  , Mustari Mohamad , Ismail  , Zubair Muh. , Hariyanto
Published: January 2023

The objectives of the paper are: (1) To identify the lesson  plan of  Pancasila and Citizenship Education Inclusion Classs in SMKN 5 Mataram, (2) To know the teaching-learning process, (3) To identify the evaluation, and (4) To highlight the difficulties faced and solutions suggested by the teacher in the teaching-learning process of Pancasila and Citizenship Education inclusion class in SMKN 5 Mataram .The research method is qualitative with the research subject Pancasila and Citizenship Education teacher level X, XI. Research informants are the headmaster, curriculum vice headmaster, student level XI, and level XII. Collected method techniques are observation, interview, document, and focus discussion group. After that, the data analysis was done by reduction, display, and conclusion with data validation. The study showed seven main results: (1) The lesson plan of Pancasila and Citizenship Education uses a scientific approach, cooperative learning model, problems-based learning, (2) The teaching-learning process Pancasila and Citizenship Education teacher level X uses challenging questions, explanation, group discussion, browsing literacy, and class communication. The teacher level  XI uses video observation, group discussion, problems identification, problems analysis, data collecting, rationing, conclusions, and presentation to the class, (3) Evaluation teaching-learning process tests 50 %, rating skills 30 %, and product of project 20 %, and (4) The difficulties faced and solution by the teacher are: (1) Some of the student lazy by persuasive to manage the time, (2) Less of learning readiness by motivation given, (3) Monopoly clever student by spread opportunities, (4) Difficulty to HOTS question by introduction clue, (5) Abnormal student minder and bullying her/his classmate by remembering to tolerance and self-confident, (6) the abnormal student difficulties faced on oral explanation by speech to text, and (7) Literacy culture is low by observation book record to develop reading motivation. The conclusion based on the lesson plan teacher document is the teaching-learning process of Pancasila and Citizenship Education has applied innovative learning process by a scientific approach, problem-based learning, L4C (Literacy, Critical thinking, Collaborative, Creative, Communication), High Order Thinking Skills by challenging question as well as revolution industry and 21 centuries required.
Pengaruh Lama Penyemprotan terhadap Kadar Enzim Cholinesterase pada Petani Pengguna Pestisida Organofosfat
Authors: Parasitekta Anggi , Purwati Purwati , Harningsih Tri
Published: January 2023

Pesticides can increase productivity in agriculture. Excessive and uncontrolled use of pesticides can pose a risk of poisoning farmers. Decreased levels of cholinesterase enzymes characterize poisoning. The duration of spraying is an indicator that can affect the levels of the cholinesterase enzyme. This study aimed to determine how long spraying affects cholinesterase enzyme levels in farmers who use organophosphate pesticides. Examination of cholinesterase using the enzymatic cholinesterase test method. The most commonly used sample is a sample of serum rather than red blood cells. The study's results stated that there was a relationship between the duration of spraying and the levels of the cholinesterase enzyme. The duration of spraying in a day gives an idea of ​​the intensity of pesticide exposure. The longer the spraying time, the higher the pesticide exposure and the decreased levels of the cholinesterase enzyme in the blood.
Effectiveness of Jambi Forest Honey and Klanceng Honey in Inhibiting Escherichia coli and Klebsiella pneumonia ESBL
Authors: Nirwana Ardy Prian , Silviani Yusianti
Published: January 2023

Bacterial resistance to antibiotics is a global problem that occurs around the world, both in hospitals and in communities. Antibiotic resistance can affect therapeutic outcomes, therapeutic costs, the spread of disease, and length of illness. The purpose of this study is to find out the potential of Jambi forest honey and Klanceng Honey in inhibiting the growth of ESBL-producing Escherichia coli and Klebsiella pneumonia. This study used experimental laboratory using posttest with control approach, conducted at the STIKES Nasional Bacteriology laboratory. The results showed that Jambi forest honey and Klanceng honey had better potential to inhibit the growth of ESBL-producing Escherichia coli and Klebsiella pneumonia than cefotaxime and ceftriaxone, but less than ceftazidime. On the other hand, honey samples had weaker inhibition potential against positive control (ciprofloxacin for K pneumoniae and chloramphenicol for E coli).
Outcome Terapi Covid-19 pada Pasien yang Mendapatkan Antikoagulan Profilaksis di RSPAL Dr. Ramelan Surabaya
Authors: Damayanti Rizki , Purnamayanti Anita , Kirtishanti Aguslina , Ediyono Ediyono
Published: January 2023

Complications of thrombotic and hemorrhagic coagulation often occur in Covid-19 patients, so it is advisable to provide anticoagulant therapy, accompanied by monitoring of parameters of coagulation abnormalities, including D-Dimer. This study aims to determine the outcome of therapy for Covid-19 in patients with anticoagulant prophylaxis use in RSPAL Dr. Ramelan Surabaya. This study is a retrospective descriptive study based on medical records of Covid-19 patients from June-August 2021. The sample in this study was subjects aged >18 years who were confirmed positive for Covid-19 based on RT-PCR, with comorbid or without comorbidities, and received anticoagulant therapy. Then, this study did not include subjects who were pregnant or with malignancy/acute conditions. From 134 research samples, it was found that the use of anticoagulants using a single anticoagulant (n=131, 97.76%) was more widely used, with the most frequently used types being enoxaparin (n=68, 50.75%), and heparin (n=48, 35,8%). In conclusion, the recovery percentage in Covid-19 subjects with anticoagulant therapy was 77.61%, and the percentage of mortality was 22,39%.
Analisis Faktor yang Mempengaruhi Kejadian Unmet Need pada Pasangan Usia Subur (PUS) di Kecamatan Pahandut Kota Palangkaraya
Authors: Rahayu Septian Mugi , Cahayani Erlina
Published: January 2023

In Central Kalimantan Province, especially in Palangka Raya, there are still sexually active couples of childbearing age and reporting want to delay having children or do not want to have more children but have not used contraceptives which are often referred to as unmet needs, as evidenced by the unmet need tolerance target in 2020, which was set at 5.73% and could only be achieved at 11.9%, this can be seen in the Radalgram date of December 2020, the National Population and Family Planning Agency (BKKBN) of Central Kalimantan Province. Analyzing the factors that influence the incidence of unmet needs in couples of childbearing age in Pahandut District, Palangka Raya City. Correlational descriptive with Cross Sectional approach. The population of this research is couples of childbearing age who are included in the category of unmet needs in Pahandut District, Palangka Raya city, totaling 2.383. The number of samples to be taken is as many as 357. The sampling technique used purposive sampling. The data was collected by a questionnaire. Data were analyzed by Chi-Square (α = > 0.05). From the results of the study, it can be seen that there is a correlation between the age of the wife and the incidence of unmet need (p = <.0001), there is a correlation between access to health facilities and the incidence of unmet need (p = 0.037), there is a correlation between husband's support and the incidence of unmet need. (p=0.007), there is a relationship between myths about family planning and the incidence of unmet needs (p=0.002). The factors of education level, wife's knowledge, wife's occupation, economic status, parity, and family planning history are not related to the incidence of unmet needs.
Deteksi Logam Berat Merkuri (Hg) pada Air dan Ikan Pasca Pertambangan Emas di Sungai Barito Kabupaten Barito Utara
Authors: Rahmadani Rahmadani , Alawiyah Tuti
Published: January 2023

The mining process is sometimes very complex, which can cause damage to the surrounding environment and cause pollution, such as chemical discharge and tailings from the mining process. The waste generated can pollute river water areas such as heavy metals Mercury, Lead, Cadmium, Nickel, and Zinc. To detect metals, an Atomic Absorption Spectroscopy (AAS) instrument is used, which is quite accurate in determining the concentration of metals at very low levels, such as elements of arsenic, antimony, lead, and mercury which can be selectively determined. Based on the qualitative test results, mercury content and levels are 0.141 mg/kg, 0.129 mg/kg, 0.025 mg/kg, 0.130 mg/kg, 0.136 mg/kg, and 0.046 mg/kg. The conclusion based on the results of mercury metal is still safe within the limits of metal contamination.
Faktor-Faktor Penyebab Covid 19 pada Pegawai UPTD Lab Kesda Dinas Kesehatan Provinsi Lampung Tahun 2022
Authors: Tanti Ampera Indah , Permatawati Handrika , Rasyid Luthfiatuzzaqiyah , Yusepa Reni , Firdaus Ramadhan R , Manulang Duwian Liwanty
Published: January 2023

Efforts to stop the spread of COVID-19 require the full cooperation of the wider community. Our ability to learn comes from observing the world using our five senses. The most significant factor in shaping a person's behavior is also knowledge. This study aims to determine the factors that cause Covid 19 in UPTD LAB KESDA employees at the Lampung Provincial Health Office. quantitative research, cross-sectional method, and analytic survey, and 43 respondents are the population and sample for this study. The sampling strategy was purposive sampling, and univariate and bivariate data analysis was performed using chi-square. 23 people (53.5%) have a high workload at the LABKESDA Health Office of Lampung Province. The level of stress in the LABKESDA Health Office of Lampung Province, as many as 24 people (55.8%) experienced stress. Immunity in LABKESDA Lampung Provincial Health Office as many as 27 people (62.8%) have low immunity. The chi-square test obtained a “p-value of 0.000 (<0.05),” which means that there is a relationship between workload and the incidence of covid 19 in the UPTD LAB KESDA Lampung Provincial Health Office. The chi-square test obtained a “p-value of 0.001 (<0.05),” which means that there is a relationship between stress levels and the incidence of covid 19 in the UPTD LAB KESDA Lampung Provincial Health Office. The chi-square test obtained a “p-value of 0.000 (<0.05),” which means that there is a relationship between immunity and the incidence of covid 19 in the UPTD LAB KESDA Lampung Provincial Health Office.
Hubungan Karakteristik dengan Kejadian Hipertensi pada Pasien Rawat Jalan di RSUD Dr. Doris Sylvanus Provinsi Kalimantan Tengah
Authors: Pebrisiana Pebrisiana , Tambunan Lensi Natalia , Baringbing Eva Prilelli
Published: January 2023

Hypertension is an increase of systolic blood pressure above the normal value is more than 140 mmHg and diastolic blood pressure of more than 90 mmHg. The characteristics of a person can also affect blood pressure; characteristics of people with hypertension are divided into several: age, gender, education, occupation, and history of hypertension. Hypertension is considered a serious disease because its impact is broad; it can even end in death. This research aims to determine the relationship between the characteristics and prevalence of hypertension. The design of this research is an analytic survey study using a Cross Sectional approach. The sampling method used is Accidental Sampling. The samples taken were 99 respondents; they were outpatients from dr. Doris Sylvanus regional Public Hospital in June-July 2022, this research data was taken using primary data by applying a questionnaire method and then analyzed by univariate and bivariate Furthermore it was tested by using a chi-square test. Research results on age, gender, education, occupation, and history of hypertension that is p-value 0.000 < 0.05 Ha is accepted. This study concludes that there is a relation between characteristics of age, gender, education, occupation, and history of hypertension and the prevalence of hypertension in dr. Doris Sylvanus Regional Public Hospital Central Kalimantan Province in 2022. People are suggested to change their unhealthy lifestyles into healthy ones in purpose avoid the risk of hypertension.
Perbedaan Kadar Trigliserida pada Millennial Vapers dan Non-Perokok di Kota Palangka Raya
Authors: Saputra Bayu Dwi , Suratno Suratno , Rahmaniati Rita , Purbayanti Dwi
Published: January 2023

Electronic cigarettes (e-cigarettes/vape) are currently millennials' most popular tobacco or nicotine product. One of the liquid content in e-cigarettes, such as nicotine, is known to stimulate the secretion of catecholamines which can cause an increase in lipolysis in the liver. As a result, free fatty acids in the liver increase, triggering an increase in hepatic triglyceride secretion into the blood vessels. This study aimed to determine the difference in triglyceride levels in millennial vapers and non-smokers. This study uses a descriptive-analytical method with a cross-sectional approach which aims to describe or describe a situation objectively, then described. The results show that the average triglyceride level in millennial vapers is 136.5 mg/dL. While in non-smokers, 91.9 mg/dL. The Mann-Whitney test results obtained a significance value of 0.042 (p < 0.05), so it can be concluded that there is a significant difference between the results of the triglyceride level examination in millennial vapers and non-smokers.
Hubungan Pengalaman dan Lama Rawat dengan Kecemasan pada Anak yang Menjalani Hospitalisasi di Ruang Rawat Inap RS Benyamin Guluh Kolaka
Authors: Patantan Reski Ika , Romantika I Wayan , Narmawan Narmawan , Andas Amzal Mortin
Published: January 2023

Hospitalization that occurs in children is an experience that interferes with children's lives which can also cause anxiety in children. Stress due to hospitalization will cause feelings of discomfort that can interfere with the treatment process. This study aims to determine the relationship between the treatment experience and the length of stay with anxiety in hospitalized children. This study used a cross-sectional study design with a total sample of 44 pediatric patients aged 3-6 years who were taken by purposive sampling. The research data were analyzed using Fisher's exact statistical test. The results showed no relationship between the treatment experience, p-value = 0.702, and the anxiety of children undergoing hospitalization. There is a relationship between the length of stay, p-value = 0.045, with anxiety in children undergoing hospitalization.
Młodzież karaimska dogaduje się w wielu językach
Authors: Pilecka Zofia
Published: January 2023

W dniach 15–17 sierpnia 2022 r. młodzi Karaimi z całej Europy przyjechali do Trok, żeby uczestniczyć w Międzynarodowym Obozie Młodzieży Karaimskiej, organizowanym w ramach obchodów Roku KaraimówLitewskich. Wydarzenie to, o karaimskiej nazwie „Bir-Bav”, czyli „Jedność”, obfitowało w wyzwania, atrakcje i konwersacje w wielu językach.
Aspirin in essential thrombocythemia. For whom? What formulation? What regimen?
Authors: Cattaneo Marco
Published: January 2023

Essential thrombocythemia (ET) is a BCR-ABL1-negative myeloproliferative neoplasm, the most common clinical manifestations of which include arterial and venous thrombosis, bleeding and vasomotor/microvascular disturbances. Low-dose (81-100 mg) aspirin once daily, which irreversibly inhibits platelet thromboxane A2 (TxA2) production by acetylating cyclo-oxygenase-1, is the recommended treatment for the control of vascular events in all ET risk categories, except patients at very low risk, who need aspirin for treatment of vasomotor/microvascular disturbances only. Simple observation should be preferred over aspirin prophylaxis in low-risk patients with platelet counts >1,000x109/L or harboring CALR mutations. Plain aspirin should be preferred over enteric coated aspirin because some ET patients display poor responsiveness (“resistance”) to the latter. When treated with a once daily aspirin regimen, adequate inhibition of platelet TxA2 production (measured as serum thromboxane B2 level) does not persist for 24 h in most patients. This phenomenon is associated with the patients’ platelet count and the number (but not the fraction) of circulating immature reticulated platelets with non-acetylated cyclo-oxygenase-1 and is therefore consequent to high platelet production (the hallmark of ET), rather than increased platelet turnover (which is normal in ET). Twice daily aspirin administration overcame this problem and proved safe in small studies. Although additional data on gastrointestinal tolerability will be useful, the twice daily regimen could already be implemented in clinical practice, considering its favorable risk/benefit profile. However, patients whose platelet count has been normalized could still be treated with the once daily regimen, because they would otherwise be unnecessarily exposed to a potential small risk of gastrointestinal discomfort.
High rate of durable responses with undetectable minimal residual disease with front-line venetoclax and rituximab in young, fit patients with chronic lymphocytic leukemia and an adverse biological profile: results of the GIMEMA phase II LLC1518 – VERITAS study
Authors: Mauro Francesca R. , Starza Irene Della , Messina Monica , Reda Gianluigi , Trentin Livio , Coscia Marta , Sportoletti Paolo , Orsucci Lorella , Arena Valentina , Casaluci Gloria Margiotta , Marasca Roberto , Murru Roberta , Laurenti Luca , Ilariucci Fiorella , Stelitano Caterina , Mannina Donato , Massaia Massimo , Rigolin Gian Matteo , Scarfò Lydia , Marchetti Monia , Levato Luciano , Tani Monica , Arcari Annalisa , Musuraca Gerardo , Deodato Marina , Galieni Piero , Patrizi Valeria Belsito , Gottardi Daniela , Liberati Anna Marina , Giordano Annamaria , Molinari Maria Chiara , Pietrasanta Daniela , Mattiello Veronica , Visentin Andrea , Vitale Candida , Albano Francesco , Neri Antonino , De Novi Lucia Anna , De Propris Maria Stefania , Nanni Mauro , Del Giudice Ilaria , Guarini Anna , Fazi Paola , Vignetti Marco , Piciocchi Alfonso , Cuneo Antonio , Foà Robin
Published: January 2023

The GIMEMA phase II LLC1518 VERITAS trial investigated the efficacy and safety of front-line, fixed-duration venetoclax and rituximab (VenR) in combination in young (≤65 years), fit patients with chronic lymphocytic leukemia and unmutated IGHV and/or TP53 disruption. Treatment consisted of the venetoclax ramp-up, six monthly courses of the VenR combination, followed by six monthly courses of venetoclax as a single agent. A centralized assessment of minimal residual disease (MRD) was performed by allele-specific oligonucleotide polymerase chain reaction assay on the peripheral blood and bone marrow at the end of treatment (EOT) and during the follow-up. The primary endpoint was the complete remission rate at the EOT. Seventy-five patients were enrolled; the median age was 54 years (range, 38-65), 96% had unmutated IGHV, 12% had TP53 disruption, and 4% had mutated IGHV with TP53 disruption. The overall response rate at the EOT was 94.7%, with a complete remission rate of 76%. MRD was undetectable in the peripheral blood of 69.3% of patients and in the bone marrow of 58.7% of patients. The 12-month MRD-free survival in the 52 patients with undetectable MRD in the peripheral blood at the EOT was 73.1%. After a median follow-up of 20.8 months, no cases of disease progression were observed. Three patients had died, two due to COVID-19 and one due to tumor lysis syndrome. The first report of the VERITAS study shows that front-line VenR was associated with a high rate of complete remissions and durable response with undetectable MRD in young patients with chronic lymphocytic leukemia and unfavorable genetic characteristics. ClinicalTrials.gov identifier: NCT03455517.
Imposibilidad de formular cargos, por presentación de informes fuera de plazos de la investigación
Authors: Tello Zamora Franklin José , Torres Wilchez Marcelo
Published: January 2023

En este trabajo se analizó, cómo la presentación extemporánea o la falta de presentación de los informes de valoración sicológica dentro del plazo de la fase investigativa en las inconductas de esta naturaleza que se tramitan en la Fiscalía de la Provincia del Cañar vulnera los derechos constitucionales a la seguridad jurídica y a la tutela judicial efectiva de la víctima. Se ha logrado determinar la importancia de darle seguimiento a las víctimas de este tipo de violencia con la finalidad de mitigar de alguna forma este problema que es notorio en la actualidad en el país. A través de la aplicación del enfoque mixto: cualitativo y cuantitativo, con un nivel de profundidad descriptivo y la utilización de los métodos inductivo y deductivo, analítico y sintético, y el dogmático jurídico se analiza los motivos que se atribuyen al mencionado incumplimiento y la repercusión que tiene sobre la situación jurídica de la víctima conforme a un marco conceptual de los derechos constitucionales mencionados con anterioridad. Con base en el análisis desarrollado, se proponen criterios generales para superar el problema identificado.
Antibody titer after vaccination against hepatitis B virus with different schedule among patients with endstage renal disease on maintenance hemodialysis
Authors: Sajjad Saker Mohammed , Ahmed Shireen , E Khoda Mohammad Mahfuz , Bhuiyan Tareq M , Azam Md Golam , Datta Indrajit Kumar , Al Mamoon Md Abdullah , Mahmud Arif
Published: January 2023

Background: Infection with the hepatitis B virus (HBV) causes high morbidity. Vaccination against HBV is very important for patients receiving hemodialysis due to end-stage renal disease (ESRD). Our study aimed to find out whether 0, 1, 2 and 6 months HBV vaccination schedule produces a better antibody response than the 0, 1, 2 months or 0,1,6 months schedule with two 20 μg [1.0 mL doses] I/M injections administered in 2 sites in each dose and to find out the overall antibody status (effectiveness) of HBV vaccine in a patient with ESRD on maintenance hemodialysis.

Methods: This cross-sectional study was conducted in the Department of Gastrointestinal, Hepatobiliary and Pancreatic Disorders (GHPD), Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) General Hospital, Dhaka, Bangladesh, from December 2020 to November 2021. All patients were collected from the Department of Hemodialysis and Nephrology diagnosed with ESRD and were on maintenance hemodialysis. Data were collected in a single sitting about their past vaccination status. An anti-HBs antibody test was sent to see the antibody status after vaccination against HBV.

Results: In this study, a total of 100 patients were selected, aged between 40 and 82 years, and the majority of the patients (63.0%) were male. Among them, 40 (40%) patients received 0, 1, 2 months schedule and 30 (30%) patients received 0, 1, 6 and rest of 30 (30%) patients received 0, 1, 2, 6 months schedule. We found patients who used the 0,1,2,6 months schedule, 54% of them achieved protective antibodies, and for patients who used the 0,1,2 and 0,1,6 months schedule, only 27% and 19% achieved protective antibodies, respectively. Their anti- HBs (titer) mean±SD were 293.93±122.38 (IU/L) with 0,1,2,6 months schedule and 126.14±132.90 (IU/L) and 276.66±152.07 (IU/L) with 0,1,2 months and 0,1,6 months schedule respectively. Overall we found that 37 (37.0%) of the patients had protective antibodies (>100 IU/l), 29 (29.0%) with low protective antibodies (10-100 IU/L), and the remaining 34 (34.0%) respondents we7re found to have nonprotective antibody (<10 IU/L).

Conclusion: Patients who received a vaccine scheduled 0,1,2,6 months achieved the highest anti-HBs titer, and the highest percentage of patients (54%) developed a protective antibody with the same schedule. So, we found that vaccine schedules (0,1,2,6 months) are preferred for better protection against HBV infection.

BIRDEM Med J 2023; 13(1): 22-26
Total extra-peritoneal inguinal hernia repair: experience in a tertiary care hospital of Bangladesh
Authors: Haque Ratan Md Ezharul , Alam Hasina
Published: January 2023

Background: Open hernioplasty, a traditional procedure, is practiced for decades all over the world, for inguinal hernia repair and the newer procedure of total extraperitoneal (TEP) inguinal hernia repair is the current trend. Aim of this study was to share the experience of TEP inguinal hernia repair.

Methods: This retrospective observational study was done from April, 2012 to March, 2021 at BIRDEM General Hospital, Dhaka, Bangladesh. Patients with inguinal hernia reporting to BIRDEM outpatient department (OPD) were counseled for TEP repair. Those who consented were treated electively with a TEP repair for a unilateral or bilateral hernia defect, either direct or indirect. All procedures were completed with patients under general anaesthesia. Polypropylene mesh was placed in preperitoneal space. Followed up records were noted at one week, one month, one and two years after surgery. Patients’ age, hernia types and locations, complications, length of stay in hospital, return to work and recurrence were noted.

Results: Total patients were 118 including one female. Patients were between 22 and 72 years. All of them had primary hernias and 72% of them underwent unilateral repairs. One of the cases required conversion to transabdominal preperitoneal procedure. In five patients (4.2%) intraoperative complication occurred and postoperative courses were complicated in 8 patients (6.7%). Patients were able to resume their daily activities after a mean period of 7 days (3 to 10 days). There was no mortality.

Conclusion: In patients with uncomplicated inguinal hernias, TEP is associated with a very low overall risk of serious complications and recurrence with a very good functional outcome. It is equally applicable with bilateral inguinal hernias without added risk.

BIRDEM Med J 2023; 13(1): 44-48
Dengue associated hemophagocytic syndrome: a case report
Authors: Nessa Azimun , Haque Hasna Fahmima , Ahmed AKM Shaheen
Published: January 2023

Hemophagocytic lymphohistiocytosis (HLH) is an aggressive and life-threatening syndrome of excessive immune activation. Several conditions are responsible for triggering HLH in clinically stable patients who respond to treatment of the underlying condition alone. These conditions include infection, rheumatological diseases and lymphoid malignancies. We are discussing a case of HLH who presented at age of 22 years that was triggered by dengue virus infection. Patient presented with an acute febrile illness and was diagnosed with dengue hemorrhagic fever. Despite appropriate supportive therapy, he had clinical deterioration. Evaluation revealed features of HLH. He was successfully treated with glucocorticoids and had an uneventful recovery. This case adds to the limited adult cases of virus-associated hemophagocytic syndrome in the literature and emphasizes the need for prompt recognition and treatment of this rare complication.

BIRDEM Med J 2023; 13(1): 49-51
From the Desk of Executive Editor Vol.13(1)
Authors: Uddin Khwaja Nazim
Published: January 2023

Abstract not available

BIRDEM Med J 2023; 13(1): 62
O uso de psicotrópicos na Atenção Primária: a medicalização na Estratégia Saúde da Família no contexto da Pandemia por COVID-19
Authors: Lima Luisa Andrade de
Published: January 2023

A pandemia da COVID-19 foi um desafio mundial para pesquisadores, gestores de saúde e governantes na procura de ações de saúde pública para diminuir o ritmo de ampliação da contaminação, com o objetivo de impedir o esgotamento dos sistemas de saúde e permitir o tratamento apropriado de complicações graves. O momento de pandemia é sensível quanto ao impacto da prescrição e uso não racional e até mesmo abusivo de medicamentos, e suas implicações se estendem para além de fármacos empregados diretamente no contexto da COVID-19, esses fatores são críticos para o aumento da medicalização. A crise pandêmica tem favorecido o aumento nos casos de sofrimento psíquico e transtornos mentais, com potencial reflexo nas prescrições de psicofármacos. Esse estudo tem como objetivo analisar o uso da medicalização na APS no contexto da pandemia por COVID-19 por meio de uma revisão integrativa. A medicalização, delimita também os problemas comportamentais, que não eram considerados médicos, mas passaram a ser tratados farmacologicamente, no contexto da pandemia por COVID-19 e foi intensificada principalmente pelo consumo de psicotrópicos como solução para os problemas cotidianos da população geradores de sofrimento psíquico, a aceitação das abordagens não farmacológicas são pouco frequentes e valorizadas.
Multiple causations of hospitalizations due to mycoses in a Brazilian region: from anthropogenic to climate factors
Authors: Nazareth Ronaldo Aquino Dusi de , Spinelli Isabela , Ferreira Larissa dos Reis , Freitas Gustavo José Cota de , Eufrasio Ludmila Gouveia , Holanda Rodrigo Assunção de , Santos Daniel de Assis , Santos Julliana Ribeiro Alves dos , Ferreira Gabriella Freitas
Published: January 2023

Fungal infections are a public health problem. Mycoses are neglected, some are related to regions with low human development and under the influence of climatic conditions. The study aimed to analyze a series of hospitalizations due to mycoses (HM) that occurred in Minas Gerais, Brazil, from 1998 to 2018, as outcomes of anthropic and climate variability. We performed predictive analyses using Spearman’s rank correlation and logistic regression modeling to determine the correlation between HM and social, demographic, economic, epidemiological, and climate factors in Minas Gerais, Brazil. Data were obtained from national databases from 1998 to 2018. We found significant correlations between HM and population size, demographic density, health facilities (negative correlations), rural population, and coffee area harvested or cultivated (positive correlations), indicating that living in small urban centers is a strong predictor. We find weak but statistically significant associations between HM and meteorological conditions. Interestingly, the outbreak of hospitalizations matched La Niña events in the municipality with the highest frequency of hospitalization due to mycoses in Minas Gerais. Complex interactions among social, demographic, economic, and climatic factors drive mycoses dynamics. This work provides evidence that climatic and human activities influences hospitalizations due to mycoses in a Brazilian region.
Ensino remoto emergencial no Amazonas: possibilidades e desafios acerca da prática pedagógica de professores de uma escola de tempo integral na cidade de Manaus-AM
Authors: Ferraz Taziana Pinheiro de Sousa , Nascimento Márcio Silveira , Oliveira Francisca Arlete Costa de
Published: January 2023

O presente trabalho analisou dificuldades e desafios do ensino híbrido, as concepções acerca da prática pedagógica de professores de uma escola de tempo integral da cidade de Manaus-AM. A presente pesquisa tem por objetivo identificar quais foram as dificuldades frente as práticas pedagógicas nesse período de aulas não presenciais. Investigou-se a prática pedagógica desde o planejamento e a sistematização da dinâmica dos processos de aprendizagem até os conteúdos e atividades que foram desenvolvidas nesse período. Foi adotada a metodologia qualitativa, tendo como instrumento, as entrevistas individuais por meio de questionário. Os resultados obtidos demonstram a importância de se conhecer como essas práticas e ferramentas utilizadas pelos professores podem impactar e interferir no processo educacional.
Sialolito de grandes proporções em glândula submandibular
Authors: Bugone Érica , Nyarwaya Raissa Nsensele , Ferreira Nadine Barbosa , Freddo Angelo Luiz , Corsetti Adriana
Published: January 2023

Introdução: A Sialolitíase é uma alteração que afeta as glândulas salivares e se caracteriza pela obstrução da glândula ou de seu ducto excretor devido a formações calcificadas chamadas de sialolitos. Objetivo e relato de caso: O objetivo desse artigo é relatar um caso raro de sialolito de grandes proporções e realizar uma discussão sobre diagnóstico e tratamento da sialolitíase. Paciente de 65 anos, sexo masculino, com queixas de aumento de volume em região submandibular à esquerda, relatando piora do quadro após as refeições, com evolução de 12 anos. No exame de tomografia computadorizada observou-se área hiperdensa de 4,0x2,0cm em suas maiores proporções. O tratamento de escolha foi a remoção do sialolito via intrabucal por técnica conservadora com preservação do ducto de Warthon através de seu cateterismo. Considerações finais: Embora a sialolitíase seja uma patologia bucal comum, a presença de sialolitos de grandes dimensões é um evento raro que demanda conhecimento e preparo para o adequado tratamento. A combinação de métodos diagnósticos adequados com intervenção minuciosa e conservadora leva a um bom prognóstico em termos de recuperação dos pacientes.
Using the quad helix to treat bruxism in children: a clinical case
Authors: Moura Mariela Dutra Gontijo de , Barbosa Maria Elisa Santos , Batista Rogério Alves , Batista Vanessa Franco Porto , Grossmann Soraya de Mattos Camargo , Brito Maria Cláudia Cardoso de , Mattos João Marcos Borges
Published: January 2023

Objective: To present a treatment for bruxism in children using quad helix as an intraoral device based on a clinical case. Methodology: A case report. Results: At the end of the treatment, the presence of the quad helix afforded enough space for the eruption of the permanent teeth, as well as had changed the child’s occlusal pattern, deprogrammed the parafunctional habit, cultivated a functional muscle pattern, reduced hyperactivity, and completely relieved all painful symptomatology. Conclusion: The use of quad helix for 4 months, along with achieving its orthodontic function, proved capable of increasing the patient’s proprioception by enhancing the non-visible recognition of the spatial location of the mandible, deprogramming the child’s bruxism, and consequently eliminating all pain in the temporal and superficial masseter masticatory muscles.