bluuebunny/crossref_metadata_2025 huggingface dataset:
Injured Myocardium‐Targeted Theranostic Nanoplatform for Multi‐Dimensional Immune‐Inflammation Regulation in Acute Myocardial Infarction
Authors: Zheng Tao , Sheng Jie , Wang Zhiyue , Wu Haoguang , Zhang Linlin , Wang Sheng , Li Jianhua , Zhang Yunming , Lu Guangming , Zhang Longjiang
Published: January 2025

Pyroptosis is a key mode of programmed cell death during the early stages following acute myocardial infarction (AMI), driving immune‐inflammatory responses. Cardiac resident macrophages (CRMs) are the primary mediators of cardiac immunity, and they serve a dual role through their shaping of both myocardial injury and post‐AMI myocardial repair. To appropriately regulate AMI‐associated inflammation, HM4oRL is herein designed, an innovative bifunctional therapeutic nanoplatform capable of inhibiting cardiomyocyte pyroptosis while reprogramming inflammatory signaling. This HM4oRL platform is composed of a core of 4‐Octyl itaconate (4‐OI)‐loaded liposomes, a middle layer consisting of a metal‐polyphenol network (MPN) film, and an optimized outer hybrid immune‐cell membrane layer. The unique properties of this hybrid membrane layer facilitated HM4oRL targeting to the injured myocardium during early‐stage AMI in mice, whereupon the release of 4‐Ol and modified MPN synergistically inhibited cardiomyocyte pyroptosis while suppressing inflammatory monocytes/macrophage responses at the infarcted site. Mechanistically, HM4oRL preserved cardiac metabolic homeostasis through AMPK signaling activation, establishing favorable microenvironmental conditions for the reprogramming of CRM‐mediated inflammation. Ultimately, HM4oRL treatment is able to resolve inflammation, enhance neovascularization, and suppress myocardial fibrosis, reducing the infarct size and enhancing post‐AMI cardiac repair such that it is an innovative approach to the targeted treatment of AMI.
Reversible Ferroelectric Polarization Modulation of Chiral Molecular Ferroelectrics by Circularly Polarized Light
Authors: Wang Zhongxuan , Wang Qian , Quan Lina , Ren Shenqiang
Published: January 2025

The optical modulation of ferroelectric polarization constitutes a transformative, non‐contact strategy for the precise manipulation of ferroelectric properties, heralding advancements in optically stimulated ferroelectric devices. Despite its potential, progress in this domain is constrained by material limitations and the intricate nature of the underlying mechanisms. Recent studies have achieved efficient regulation of ferroelectric polarization and thermal conductivity in chiral ferroelectric thin films through the application of left‐ and right‐handed circularly polarized light (LCP and RCP). Differential absorption of circularly polarized light (CPL) induces nonequilibrium carrier dynamics, generating distinctive interfacial electrostatic fields that enable precise control of ultrathin ferroelectric films. For (R)‐BINOL−DIPASi and (S)‐BINOL−DIPASi (C26H26O2Si), polarization changes surpass 23%, exhibiting opposite response under LCP and RCP excitation. In R chiral films, remnant polarization decreases from 1.05 µC cm−2 under LCP to 0.85 µC cm−2 under RCP, whereas in S chiral films, polarization increases from 0.85 µC cm−2 under LCP to 0.98 µC cm−2 under RCP. This reversible modulation facilitates reliable switching between ON and OFF states, presenting the potential of chiral ferroelectric materials for flexible, high‐speed integrated photonic sensor technologies.
Prognostic factors for patients with esophageal cancer who achieve pathological complete response in the primary tumor after upfront chemotherapy or chemoradiotherapy
Authors: Motoori Masaaki , Tanaka Koji , Miyata Hiroshi , Yamasaki Makoto , Shiraishi Osamu , Takeno Atsushi , Makino Tomoki , Sugimura Keijiro , Yasuda Takushi , Doki Yuichiro
Published: January 2025

Aim

Upfront chemotherapy (uCT) or upfront chemoradiotherapy (uCRT) followed by surgery is generally accepted as the standard treatment for patients with locally advanced esophageal cancer. A substantial proportion of patients achieve a pathological complete response (pCR) of the primary tumor with upfront treatment. This retrospective study aimed to clarify the prognostic factors of patients with esophageal cancer who achieve pCR in the primary tumor after upfront treatment and whether the prognosis of patients with pCR who receive uCT differs from that of patients who receive uCRT.

Methods

This study included 121 patients who achieved pCR of the primary tumor after uCT and 40 patients after uCRT. Univariate and multivariate survival analyses were performed.

Results

Multivariate analysis of overall survival demonstrated that gender, upfront treatment, and pathological lymph node metastasis were independent prognostic factors (p = 0.0086, 0.011, and 0.031, respectively). Multivariate analysis of relapse‐free survival demonstrated that gender, cM status, and pathological lymph node metastasis were independent prognostic factors (p = 0.033, 0.014, and 0.0010, respectively). Among patients without pathological lymph node metastasis, the uCT group showed significantly better both overall and relapse‐free survival than the uCRT group (p = 0.014 and 0.037, respectively). Recurrence occurred in 24 patients in the uCT group and 9 in the uCRT group. All of local treatment (chemoradiotherapy and surgery) for recurrent lesions was performed in the uCT group.

Conclusions

Male genders and pathological lymph node metastasis are independent poor prognostic factors in patients with esophageal cancer who receive upfront treatment followed by surgery and achieved pCR of the primary tumor.
An Investigation Into the Influence of Titania–Carbon Nanotube Nanophotocatalysts Into the Filtration Performance of Polyethersulfone‐Based Membranes
Authors: Zikalala Sithembela A. , Mahlangu Oranso T. , Li Jianxin , Mamba Bhekie B. , Nxumalo Edward N.
Published: January 2025

The polyethersulfone/sulfonated polyethersulfone (PES/SPSf) blend is enriched with ionizable sulfonic acid groups rendering a stable polymer system suited for blending nanocomposites using water as a dispersant. PES/SPSf/TiO2‐amorphous carbon nanotubes (aCNT) mixed matrix membranes are prepared via addition of a TiO2–aCNT/deionized water slurry and precipitated via non‐solvent induced phase separation. Membranes' electrostatic and non‐electrostatic interactions with charged organic pollutants and membrane–dye interactions are probed using the Liftshitz‐acid–base approach. Fluid transport and solute rejection mechanisms are investigated through porosity, pore radius, flux, permeance, dye rejection and fouling propensity. PES/SPSf/TiO2–aCNT membrane contact angle at 1.6 wt.% TiO2–aCNT loading reached 35° accompanied by pore radius decrease and a decline in membrane pure water permeability (197.7 for MF0 to 48.5 L.m−2.h−1 for MF1.6). Membranes had good rejection for cationic azure B (≈90%) and zwitterionic rhodamine B (≈100%) compared to anionic charged methyl orange (MO) (2.0%–10.8%). Major dye removal mechanism was size exclusion, where reactive red 120 (1335.9 g/mol) retention was higher than that of MO (327.4 g/mol). TiO2–aCNT loading imputes membranes additional cationic charge and electron donor components that enables solute transportation via electrostatic switching mechanism and charge‐dependent antifouling for reactive dyes, which are the bulk of textile industry pollution.
Small fish, large variation: Morphological diversity of Weberian apparatus in Noturus catfishes and ecological implications
Authors: Hoeflich J. C. , Liu Juan
Published: January 2025

The Weberian apparatus is a hearing specialization unique to the otophysan fishes, and an unexpected degree of morphological variation exists in species of the Noturus catfishes. Our aim in this study is to investigate relationships between morphological variations and ecology that may drive this variation. Sampling 48 specimens representing 25 species, we investigated morphological diversity and accounted for ecological variables using landmark‐based 3D geometric morphometrics and x‐ray‐based computed tomography (CT) images. We tested five ecological variables using three landmark sets in three focused regions: the tripus, scaphium, and overall shape of the peripheral structures including the complex vertebra. We performed phylogenetic signal tests, and phylogenetic influence is not significant within Noturus in any of the three regions. Among the tested ecological variables, stream velocity and coloration (a proxy for substrate) were found to be significantly associated with the morphology of the tripus and scaphium, the first and the last ossicles of the sound transmitting chain. This eco‐morphology connection may be mediated through stream velocity's dominant role in defining the soundscape of aquatic environments and substrate material properties contributing to which sounds are produced and propagated. We conclude that Noturus catfishes could be acoustically adapted to their microhabitats.
Dynamic Capabilities as Enablers for Sustainability‐Oriented Innovation: A Case Study in a Footwear Industry
Authors: Gohr Cláudia Fabiana , Rodrigues Bruna Cavalcanti Barros
Published: January 2025

The literature indicates the relevance of sustainability‐oriented innovation (SOI). However, the knowledge about the influence of dynamic capabilities (DCs) and critical factors (CFs) in developing these innovations is still insufficient. This paper aims to analyze the DCs' influence (through CFs) in developing SOIs through an in‐depth explorative case study in two Brazilian unities at a multinational shoe company. The empirical results showed that the development of SOIs depends on the high influence on environmental, resource integration, and technological capabilities and moderate influence on absorptive, organizational, and networking capabilities due to the absence or nonstructuring of its CFs. “Waste management” (related to environmental DC) and “reputation (related to organizational DC)” emerged from empirical evidence. The paper provides empirical evidence of DC's influence (through CFs) in developing SOIs by suggesting eight propositions.
The Social Innovation of Academic Spin‐Offs From a Multilevel Approach
Authors: Camelo‐Ordaz Carmen , Diánez‐González Juan Pablo , Franco‐Leal Noelia , Sousa‐Ginel Elena
Published: January 2025

The academic entrepreneurship literature has yet to consider the factors that affect social innovation in academic spin‐offs. Given this gap, this study adopted a knowledge‐based perspective and considers the antecedents of social innovation at two levels of analysis: academic spin‐offs and parent universities. Specifically, we analyzed the influence of academic spin‐offs' technological competence, entrepreneurial team functional heterogeneity, and funding type; and the moderating role of the parent university's social responsibility. A multilevel analysis was applied to a sample of 165 academic spin‐offs. The results revealed that technological competence, entrepreneurial team functional heterogeneity, and public funding sources positively influenced social innovation. However, venture capital funding negatively affected innovation. The results also showed that the parent university's social responsibility moderated the effect of functional heterogeneity but not the influence of technological competence. These findings contribute to the integration of the academic entrepreneurship literature within the field of social innovation.
Changes in Circadian Rhythm in Chronically‐Starved Mice Are Associated With Glial Cell Density Reduction in the Suprachiasmatic Nucleus
Authors: Zimmermann Annelie , Priebe Julia , Rupprecht Hanna , Lang Stephan , Haberland Fabienne , Schuster Katharina , Staffeld Anna , Berger Christoph , Zhu Hang , Dück Alexander , Kölch Michael , Frintrop Linda
Published: January 2025

Objective

Anorexia nervosa (AN) is an eating disorder characterized by severe weight loss and associated with hyperactivity and circadian rhythm disruption. However, the cellular basis of circadian rhythm disruption is poorly understood. Glial cells in the suprachiasmatic nucleus (SCN), the principal circadian pacemaker, are involved in regulating circadian rhythms. We hypothesize that the circadian rhythm disruption in AN patients is associated with glial cell changes in the SCN.

Method

In the starvation‐induced hyperactivity mouse model, mice had free access to a running wheel and received a restricted amount of food once a day, until a 25% body weight loss was reached and maintained their weight loss for two weeks. This was followed by a refeeding phase. Different daily periods of running wheel activity were defined, such as food anticipatory activity up to 4 h before feeding. Circadian rhythmicity was analyzed using the cosinor method. Gene expression was evaluated using real‐time polymerase chain reaction. Immunohistochemistry was used to quantify astrocytes, microglia, and oligodendrocytes.

Results

Starvation induced changes in circadian rhythm, as indicated by changes in cosinor‐based characteristics. Refeeding reversed these effects. Additionally, there was an increase in cryptochrome circadian regulator 1 expression and a decrease in the density of astrocytes and oligodendrocytes in the SCN after chronic starvation.

Discussion

Starvation‐induced alterations in circadian rhythms are associated with molecular, and cellular changes in the hypothalamus. Reduced astrocytes and oligodendrocytes in the SCN in a mouse model of AN suggest that glial pathophysiology may play a role in circadian rhythm disruption.
The Impact of Astroglia Kir4.1 Channel Dysfunction on Neuronal Activity and Autism‐Related Behavioral Abnormalities
Authors: Davoudi Shima , Rahdar Mona , Borjkhani Mehdi , Alavi‐Majd Hamid , Hosseinmardi Narges , Behzadi Gila , Janahmadi Mahyar
Published: January 2025

Autism spectrum disorder (ASD) is marked by neurobehavioral developmental deficits, potentially linked to disrupted neuron–glia interactions. The astroglia Kir4.1 channel plays a vital role in regulating potassium levels during neuronal activation, and mutations in this channel have been associated with ASD. This study investigates astroglia Kir4.1 as a regulator of neuronal excitability and behavioral abnormalities in rats with autistic‐like traits induced by prenatal exposure to valproic acid (VPA). Whole‐cell patch‐clamp recordings were obtained from pyramidal neurons in the hippocampal CA1 region, showing that inhibition of Kir4.1 channels led to electrophysiological changes indicative of neuronal hyperexcitability, similar to that seen in VPA‐exposed neurons. Specifically, there was increased input resistance and voltage threshold, alongside decreased time constant and rheobase. Behavioral assessments after 7 days of intrahippocampal PA6 (5 μg/mL/day) administration revealed significant social withdrawal, heightened anxiety, reduced exploration, and impaired recognition memory, underscoring the behavioral deficits linked to autism. While Kir4.1 inhibition affected excitability, it did not alter the output of CA1 pyramidal neurons in autistic‐like rats. These findings emphasize the critical role of astroglia Kir4.1 channels in modulating neuronal excitability and associated behavioral impairments within the VPA‐induced autism model, suggesting a promising target for future therapeutic interventions.
Management of Clinically Node‐Negative Salivary Gland Cancer: Observation, Neck Dissection, or Neck Irradiation?
Authors: Ilori Evelyn O. , Woody Neil M. , Hair Bryan B. , Rybicki Lisa , Lamarre Eric D. , Ku Jamie Ahn , Prendes Brandon , Scharpf Joseph , Burkey Brian B. , Koyfman Shlomo A. , Campbell Shauna R.
Published: January 2025

Introduction

Salivary gland malignancies are heterogeneous tumors with highly variable outcomes. Elective neck management options include observation, neck dissection (ND), and neck irradiation (NI). We sought to compare outcomes of cN0 salivary gland cancer by elective neck management.

Methods

An IRB‐approved registry was queried for cN0 salivary gland cancers and categorized based on neck management into observation, ND, NI, and ND + NI groups. cN0 included no evidence of clinical or radiographic metastatic lymphadenopathy.

Results

A total of 445 patients were included with 203 in observation, 83 ND, 71 NI, and 88 ND + NI. Median follow‐up was 60.8 months (range 0.4–258). There were 47% clinical T1 tumors, 29% T2, and 12% of each T3 and T4. Exactly 90% were cN0 and 10% with borderline lymph node(s). The major salivary gland was the most common site (74%) and the most common histologies included 28% mucoepidermoid and 20% adenoid cystic. Risk factors associated with regional recurrence include age, borderline lymph node features, pathologic T and N stage, poorly differentiated, positive margin, lymphovascular space invasion, and extranodal extension (all p < 0.05). There was no significant difference in local (9.9%–16.7%, p = 0.6) or regional (3.9%–9.4%, p = 0.76) recurrence between all four groups. Five‐year distant recurrence was significantly different at 7% for observation, 16% in ND, 25% in NI, and 37% in ND + NI (p < 0.001). Ten‐year OS estimates were 78% for observation, 66% for ND, 69% for NI, and 52% in ND + NI (p < 0.001).

Conclusion

For patients with cN0 salivary gland cancer, ND and NI yield similar regional control in appropriately selected patients. In high‐risk patients with several adverse risk features ND + NI results in favorable regional control but distant metastasis is a driving factor affecting overall survival.
Comparing PD‐L1 and PD‐1 inhibitors plus bevacizumab combined with hepatic arterial interventional therapies in unresetable hepatocellular carcinoma: A single‐center, real‐world study
Authors: He Minrui , Xie Wa , Yuan Ze , Chen Jinbin , Wang Juncheng , Fu Yizhen , Hu Zili , Meng Qi , Gao Wenqing , Hu Dandan , Zhang Yaojun , Pan Yangxun , Zhou Zhongguo
Published: January 2025

With the rise of anti‐vascular endothelial growth factor antibody and programmed cell death‐ligand 1 (PD‐L1) regimens, particularly bevacizumab and atezolizumab, as first‐line treatments for advanced hepatocellular carcinoma (HCC), there is a need to explore PD‐L1 and programmed cell death 1 inhibitors in combination therapies for unresectable HCC (uHCC). Integrating systemic therapies with locoregional approaches is also emerging as a potent strategy. This study compares the outcomes of atezolizumab (PD‐L1 inhibitor) and sintilimab (programmed cell death 1 inhibitor) with bevacizumab or its biosimilar, combined with hepatic arterial interventional therapies (HAIT) in uHCC patients. From January 2020 to September 2023, a retrospective analysis was conducted on 138 uHCC patients at Sun Yat‐sen University Cancer Center. The cohort included 69 patients treated with atezolizumab with bevacizumab (Bev/Ate) and 69 with bevacizumab biosimilar with sintilimab (Bio/Sin), combined with HAIT. The propensity score matching was also employed to further explore the efficacy and safety. The median progression‐free survival (mPFS) was 13.8 months for the Bev/Ate group and 10.0 months for the Bio/Sin group (p = 0.188). The Bev/Ate group showed significantly longer intrahepatic mPFS (HR 0.381; 95% confidence interval 0.176–0.824; p = .018) and higher overall response rates compared with the Bio/Sin group (60.87% vs. 31.88%, p = .001; 69.57% vs. 49.28%, p = .024) based on Response Evaluation Criteria in Solid Tumors v1.1 and modified Response Evaluation Criteria in Solid Tumors criteria. Treatment‐related adverse events were similar between groups (p > .050). Combining atezolizumab or sintilimab with bevacizumab or its biosimilar alongside HAIT provided similar overall PFS in uHCC patients. However, the atezolizumab‐bevacizumab combination with HAIT showed superior intrahepatic PFS and control rates, warranting further validation.
Digitalisation and Firm‐Level ESG Performance and Disclosures: A Scientometric Review and Research Agenda
Authors: Singhania Monica , Bhan Ibna , Seth Surabhi
Published: January 2025

Digitalisation and sustainability are not just critical business notions; they are also interdependent drivers of future business success. By employing digital tools, firms can improve their environmental, social, and governance (ESG) performance, increase transparency, and maintain stakeholders' accountability. This increasing significance has elevated the value of examining the impact of digitalisation on firm‐level ESG performance and disclosures. This study explores this relationship by synthesising 199 relevant research records published during 2019–2024, obtained from Web of Science and Scopus, using a bibliometric and systematic literature review approach. Our descriptive analysis reveals exponential growth in publications on this relationship during the study period, focusing predominantly on quantitative research leveraging secondary data. Regression analysis emerged as the most popular analytical technique, followed by structural equation modelling. The theoretical foundations of this research are based on the resource‐based view and dynamic capabilities view. The Co‐occurrence analysis identifies China, Italy, and England as the leading contributors, with research hot spots centring around concepts such as ‘Industry 4.0’, ‘sustainability performance’, ‘sustainable development’, and ‘sustainability reporting’. Co‐citation analysis highlights the leading journals, authors, and documents, emphasising the scholarly foundations of this field. Further, thematic analysis uncovers the benefits of digitalisation across four dominant dimensions: sustainability performance, supply chain sustainability, sustainability assessment, and sustainability accounting and reporting. Finally, we discuss critical knowledge gaps and propose future research questions to advance understanding of this emerging field.
Sexual Minority Stress: Preliminary Evidence of Accelerated Pubertal Development in Early Adolescence
Authors: Papke Victoria , Wiglesworth Andrea , Carosella Katherine A. , Başgöze Zeynep , Green Aurora E. , Fiecas Mark , Cullen Kathryn R. , Klimes‐Dougan Bonnie
Published: January 2025

Introduction

Societal stressors place a tremendous burden on individuals who identify with a sexual minority identity. While minority stress experienced by racial/ethnic minority groups has been linked to accelerated aging, this link has yet to be examined among sexual minority youth. This study explores whether sexual minority youth who indicate experiencing stress at home or school (Minority Stress) due to their identity show evidence of accelerated aging (pubertal status or tempo) compared to those who do not report such experiences (No Minority Stress).

Methods

Data are from the Adolescent Brain Cognitive Development (ABCD) Study. Participants were approximately 9–10 years old at baseline, 10–11 years old at Time 1, and 11–12 years old at Time 2. Measures included child‐reports of sexual minority identity and stressors, and parent‐reports of adolescent pubertal development.

Results

Among 432 included participants who identified with a sexual minority identity, 83.6% were assigned female at birth and 24.8% were in the Minority Stress group. There were consistent results showing that sexual minority youth in the Minority Stress group showed accelerated pubertal status over time compared to those in the No Minority Stress group. Pubertal tempo (i.e., slope) was only accelerated for those who first identified as sexual minority at Time 2.

Conclusion

Our findings underscore that minority stress experienced by sexual minority youth may be linked to differences in pubertal development among these youth. The developmental and clinical implications of these patterns present critical lines for future research concerned with the wellbeing of sexual minority youth.
The Role of Proton Magnetic Resonance Spectroscopy in Neonatal and Fetal Brain Research
Authors: Hui Steve C.N. , Andescavage Nickie , Limperopoulos Catherine
Published: January 2025

The biochemical composition and structure of the brain are in a rapid change during the exuberant stage of fetal and neonatal development. 1H‐MRS is a noninvasive tool that can evaluate brain metabolites in healthy fetuses and infants as well as those with neurological diseases. This review aims to provide readers with an understanding of 1) the basic principles and technical considerations relevant to 1H‐MRS in the fetal‐neonatal brain and 2) the role of 1H‐MRS in early fetal‐neonatal development brain research. We performed a PubMed search to identify original studies using 1H‐MRS in neonates and fetuses to establish the clinical applications of 1H‐MRS. The eligible studies for this review included original research with 1H‐MRS applications to the fetal‐neonatal brain in healthy and high‐risk conditions. We ran our search between 2000 and 2023, then added in several high‐impact landmark publications from the 1990s. A total of 366 results appeared. After, we excluded original studies that did not include fetuses or neonates, non‐proton MRS and non‐neurological studies. Eventually, 110 studies were included in this literature review. Overall, the function of 1H‐MRS in healthy fetal‐neonatal brain studies focuses on measuring the change of metabolite concentrations during neurodevelopment and the physical properties of the metabolites such as T1/T2 relaxation times. For high‐risk neonates, studies in very low birth weight preterm infants and full‐term neonates with hypoxic–ischemic encephalopathy, along with examining the associations between brain biochemistry and cognitive neurodevelopment are most common. Additional high‐risk conditions included infants with congenital heart disease or metabolic diseases, as well as fetuses of pregnant women with hypertensive disorders were of specific interest to researchers using 1H‐MRS.

Evidence Level

1

Technical Efficacy

Stage 2
Comparison of LEIS, SIMS, and AR‐XPS as Methods for Surface Characterization of Passivated Zn–Al–Mg Steel
Authors: Ponomareva Maria , Duchoslav Jiri , Stifter David , Kogler Matthias , Fahrnberger Florian , Hutter Herbert , Luckeneder Gerald , Hader‐Kregl Laura , Valtiner Markus
Published: January 2025

The combination of different surface‐sensitive techniques is frequently used in material sciences to analyze complex systems. How these methods compare in terms of quantitative and qualitative information is often unclear. In this study, we directly compare low‐energy ion scattering spectroscopy (LEIS), secondary ion mass spectrometry (SIMS), and angle‐resolved X‐ray photoelectron spectroscopy (AR‐XPS) depth profiling analyses. Therefore, we use the Zn–Al–Mg model coatings after alkaline and acidic treatments in model solutions. The combined use of AR‐XPS and LEIS depth profiling proved effective in studying compositional and elemental changes in the surface oxides of Zn–Al–Mg coatings after alkaline and acidic treatments. Additionally, by combining these methods, SIMS depth profiling can be effectively calibrated for matrix effects. Here, we find that, for example, Mg is considerably more sensitive to SIMS detection, based on effective secondary ionisation. Such effects must be considered for data interpretation.
How Second Screens Shape Consumer Experiences: The Role of Social Connection on Repeat Viewing
Authors: Wu Will Wei , Powell Emily R. , Barasch Alixandra
Published: January 2025

The use of additional electronic devices, such as smartphones or tablets, for sharing, reviewing, and communicating online has become an integral part of consumers' media consumption experiences. Previous research has demonstrated that using connected devices during consumption experiences mainly serves to decrease the utility consumers derive from their experiences. In contrast, the present research examines when second screen use might have a positive effect on the media consumption experience. Across three studies using a variety of real‐world media consumption experiences, we demonstrate that second screen use enhances consumers' feelings of social connection, which in turn increases their likelihood of repeating the media consumption experience. We also identify the viewing context as a theory‐driven and practically‐relevant moderator: second screen use enhances feelings of social connection and repeat viewing when viewers are watching alone, but this effect reverses when viewers are watching with others. These findings have clear substantive implications for a variety of industry stakeholders, including broadcasters, content creators, and platform developers who wish to capture greater consumer attention and foster long‐term viewer loyalty.
LINC01305 and LAD1 Co‐Regulate CTTN and N‐WASP Phosphorylation, Mediating Cytoskeletal Reorganization to Promote ESCC Metastasis
Authors: Yang Hang , Xiong Rong , Zhang Ruolan , Sun Shan , Pan Yingjie , Zhao Quanneng , Bie Jun , Luo Yi , Song Guiqin , Liu Kang
Published: January 2025

Esophageal squamous cell carcinoma (ESCC) is prone to metastasis and is a leading cause of mortality. The cytoskeleton is closely related to cell morphology and movement; however, little research has been conducted on ESCC metastasis. In this study, we found that the anchoring filament protein ladinin 1 (LAD1) specifically binds to LINC01305 for co‐regulating the level of modulating cortactin proteins (CTTN) and neuronal Wiskott–Aldrich syndrome protein (N‐WASP) phosphorylation, which mediates cytoskeletal reorganization and affects the metastasis of ESCC cells. Additionally, LINC01305 and LAD1 jointly promoted the epithelial–mesenchymal transition (EMT) process by activating the phosphoinositide‐3‐kinase–protein kinase B (PI3K/AKT) signaling pathway. Moreover, LINC01305 and LAD1 were related to the late clinical stage and lymph node metastasis of ESCC. Our study demonstrated that LINC01305 and LAD1 are major determinants of ESCC dissemination and revealed a novel molecular mechanism of cytoskeletal reorganization that controls ESCC metastasis.

Trial Registration: N/A.
Simulation and experiment investigation on leakage rate of composite materials with the consideration of curing defects
Authors: Liu Shu , Zhan Lihua , Ma Bolin , Zhang Dechao , Yao Shunming , Chen Weitao , Du Chuan
Published: January 2025

This study investigates the influence of curing defects on the leakage behavior of CFRP. A macroscopic homogeneous leakage model incorporating curing defects was developed to account for their impact on leakage. By combining simulation and experimental methods, the relationship between curing defects and leakage rates was analyzed. The results indicate a positive correlation between leakage rate and porosity. Furthermore, the leakage rate is also influenced by the void spacing, where an initial increase in spacing leads to a rise in leakage rate, followed by a stabilization at later stages. In addition, the leakage rate shows a negative correlation with both the distance between voids and the high‐pressure side, as well as the aspect ratio of the voids. Based on these findings, a defect morphology with enhanced leak resistance is proposed.

Highlights

A leakage simulation model for CFRP with void defects has been established.

The mechanisms were investigated through simulation and experimentation.

Revealed the influence of CFRP pore distribution and morphology on leakage rate.

The void characteristics of CFRP with high leakage resistance were obtained.
Experimental evaluation of residual tensile properties of CFRP‐aluminum butt adhesive joints subjected to systematic creep damage
Authors: Saeidi Googarchin Hamed , Bidadi Jamal
Published: January 2025

This study investigates the creep behavior and static mechanical response after creep of CFRP‐Aluminum adhesive joints subjected to sustained tensile loads. Initially, quasi‐static tensile tests were performed to determine the instantaneous static load (). Subsequently, creep tests were conducted at seven sustained load levels (i.e., 80%, 70%, 60%, 50%, 40%, 30%, and 20% of ) for durations ranging from 12 to 72 h. The main aim was to assess how creep affects the residual static mechanical properties of joints. Analysis of the creep curves revealed that the tested joints tolerated only 20%–50% of the creep load for the maximum specified creep duration (i.e., 72 h). Premature joint failure was observed under creep loads exceeding 50% of before reaching the maximum designated creep duration. Following this, tensile after creep (TAC) tests were performed on the creep‐loaded joints (i.e., those subjected to 20%–50% of ) at a crosshead speed of 0.5 mm/min. These tests aimed to determine the variations in the joint's residual mechanical properties. The TAC results indicated that the tensile stresses were primarily tolerated by the adhesive, with no significant delamination observed in the CFRP substrate. Notably, considerable reductions in residual properties (both strength and strain) were noted for longer creep durations, which were attributed to adhesive degradation. Conversely, reductions were minimal for shorter creep durations. Finally, semi‐empirical models were developed to predict the residual tensile properties of the joints for use in numerical simulations of creep behavior in future research.

Highlights

Examining creep and post‐creep tensile behavior in hybrid adhesive joints.

Increased joint creep strain with higher creep load levels.

Reduction in joint residual strength post‐creep.

Creep causes reduced flexibility in the joint.
Construction and phase transition characteristics of nano‐graphite‐induced rapid growth self‐generated proppants
Authors: Xu Min , Yin Jinrong , Li Zhenyong , Jiang Yangqi , Bismark Opoku , Fu Xiaoji , Song Yu , Ren Xianyan , Zhong Yuwang
Published: January 2025

To solve the problem that the self‐generated proppant in fractures grows slowly and cannot support the fractures in time, nano‐graphite (NG) was introduced into a phase change liquid (PCL) composed of “styrene‐divinylbenzene (SDB)” and the resulting self‐generated proppants were constructed with a high growth speed. The NG/PCL started the phase transition from liquid to solid after 8 min at about 55°C in the wellbore section, and the phase transition was completed for only 2.5 min at a constant temperature of 65°C in fracture. Moreover, due to the high thermal conductivity and heterogeneous nucleation of the NG powder, the maximum strength of self‐generated proppant in the NG‐containing system can reach about 56.2 N during its growth process, which is 34.4% higher than that of pure SDB. The yield of the well‐dispersed spherical self‐generated proppants NG/SDB under the completely static condition can reach about 80%, of which the proppants with a particle size of 0.4 ~ 0.7 mm account for about 80%. NG/SDB exhibited an ultra‐low apparent density of approximately 1.004 g/cm3, high compressive strength, and a crushing ratio of less than 1% at a closure pressure of 52 MPa, which is lower than that of commercial quartz sand and ceramsite proppants.

Highlights

Self‐generated proppants with rapid growth were developed by the introduction of NG.

Positive effects of NG in PCL system are obvious on phase transition and growth.

NG/SDB is qualified in phase transition timing and compressive strength.

The single‐microsphere yield of NG/SDB is about 80%.

The crushing ratio of NG/SDB as low as 3.92% at a closure pressure of 69 MPa.
Effects of poly(propylene carbonate) on poly(butylene adipate‐co‐terephthalate) microcellular foams: Improved expansion and reduced shrinkage
Authors: Yan Hai‐kuo , Sheng Hao‐nan , Hua Huang‐wei , Zhang Li , Yao Yu‐yuan , Bao Jin‐biao
Published: January 2025

Microcellular foams made from poly (butylene adipate‐co‐terephthalate) (PBAT) using supercritical carbon dioxide (scCO2) as a physical foaming agent have exhibited high shrinkage and low expansion ratios, limiting their potential applications. Previous studies have indicated that while PBAT exhibits foaming capabilities, its maximum expansion ratio typically does not exceed 20, and it is characterized by a high shrinkage ratio, which limits its application in high‐performance foams. In contrast, this study presented an 80PBAT/20PPC microcellular foam that has achieved a stable expansion ratio of 38.9 and a substantial reduction in shrinkage ratio to 9.4% from the 89.5% observed in pure PBAT. This advancement is attributed to the blending of PBAT with poly(propylene carbonate) (PPC), a polymer with moderate compatibility. PPC was uniformly dispersed within the PBAT matrix in micro/nano particle form, which inhibited crystallization and leveraged its unique molecular structure to enhance CO2 solubility, thereby increasing the expansion ratio and refining the cell structure. Additionally, PPC particles acted as stress concentrators, promoting cell wall rupture and forming an open‐cell structure. Furthermore, the higher glass transition temperature (Tg) of PPC further enhanced the stiffness of the cell walls. These synergistic effects enabled PBAT/PPC microcellular foams to effectively resist shrinkage caused by internal–external pressure differentials.

Highlights

Blending with PPC increased the expansion ratio of PBAT foams to 38.9.

Shrinkage of 80PBAT/20PPC foams is drastically reduced to 9.4%.

PPC in PBAT matrix enhanced CO₂ solubility and inhibited crystallization.

PPC particles acted as stress concentrators, facilitating open‐cell structure.
Differences in Labour Mobility Between Immigrant Generations: Evidence From the European Debt Crisis
Authors: Braun Marius , Görts Jarom
Published: January 2025

Immigrants' higher responsiveness to regional differences in labour market conditions has been recognised as a potentially important adjustment mechanism to labour market shocks. This paper investigates an aspect less explored by previous research, namely how labour mobility patterns are passed on across immigrant generations. Using Euro Area household‐level data, we compare mobility patterns of first‐ and 1.5‐generation immigrants and natives. We observe that 1.5‐generation immigrants have a significantly lower interregional and international mobility compared to first‐generation immigrants but are more mobile than natives. Our results suggest that not only first‐generation immigrants but also their descendants contribute to labour market flexibility.
An object‐based method to study the life cycle of mesoscale convective systems and their environment from cloud‐resolving AROME‐France simulations
Authors: Arnould Gabriel , Montmerle Thibaut , Rottner Lucie , Moisselin Jean‐Marc
Published: January 2025

An object‐based methodology is used to study the mesoscale convective systems (MCSs) developing in France and the interactions they have with their environment during their life cycle. MCSs are detected from images of radar reflectivity and satellite 10.8‐ brightness temperature with a deep‐learning segmentation method. The ability of the Application of Research to Operations at Mesoscale (AROME‐France) numerical weather prediction model in representing MCSs is first assessed by comparing statistically the attributes of objects tracked in simulated and observed images of severe convective situations between 2018 and 2022. The MCS environment is then studied by averaging ambient variables simulated by AROME‐France within a 100‐km wide area and calculating original ring‐shaped composite maps adapted to the geometry of each object. Based on this methodology, it is shown that MCSs generally develop in unstable areas with low‐level convergence and strong wind aloft. Ambient instability correlates best with MCS severity and maintenance. It undergoes the greatest decrease throughout the life cycle, in relation with low‐level cooling and drying. Further comparisons are made between quasi‐stationary Mediterranean and other MCSs, and particular attention is paid to the impact of the system on its own environment. We finally emphasise three relevant predictors for MCS nowcasting in France: (1) the trend in system size and convective activity, (2) the ambient instability, and (3) the midlevel wind to anticipate MCS movement.
Synthesis of Small Molecule Library of Novel Nicotinamide Derivatives as Anticancer Agents and Computational Screening
Authors: Malothu Ram Mohan , Thalari Gangadhar
Published: January 2025

A small molecule library of nicotinamide derivatives synthesized and characterized their structure by interpretation of 1H NMR, 13C NMR, and Mass spectral data. The new molecules were screened for their in vitro anticancer activity against human breast (MCF‐7) and cervical (HeLa) cell lines by using Doxorubicin as standard reference. Pyridine linked nicotinamide derivatives displayed potent activity against both the cell lines. The trifluoromethyl substituted pyridine analogue demonstrated outstanding activity with IC50 value of 8.70 ± 0.23 µM and 8.97 ± 0.31 µM against MCF‐7 and HeLa cell lines respectively, with respect to Doxorubicin IC50 value of 9.06 ± 0.36 µM (MCF‐7) and 9.17 ± 0.39 µM (HeLa). The compound 6 with thiomethyl group displayed activity with IC50 value of 9.01 ± 0.38 µM and 9.82 ± 0.41 µM against MCF‐7 and HeLa cell lines correspondingly. The methyl substituted compound 5h  displayed encouraging activity with IC50 value of 10.47 ± 0.41 µM (MCF‐7) and 11.87 ± 0.45 µM (HeLa). Molecular docking study performed using potent molecules 5h , 5i, and 6 against estrogen receptor alpha (PDB ID: 3ERT), obtained highest docking score value for ligand 5i (9.5 kcal/mol). The predicted ADME of compounds indicated their drug‐like characteristics.
Silver Bio‐Nanoparticles Synthesis from Tetraclinis articulata Leaves Extract and Their Anti‐Inflammatory, Antioxidant, and Cytotoxicity Activities
Authors: Al Moudani Nada , Ouahidi Ibtissam , Laaraj Soukaina , Aarab Lotfi
Published: January 2025

The aim of this study was to explore the potential of bio‐silver nanoparticles (Ag‐NPs) synthesized from Tetraclinis articulata extract, a Moroccan plant, for the treatment of inflammatory diseases related to oxidative stress, such as arthritis, cardiovascular diseases and metabolic disorders. The objective was to reduce inflammation and neutralize free radicals by transferring the therapeutic properties of secondary metabolites of the plant to nanoparticles. The synthesis of Ag‐NPs was carried out by an environmentally friendly method, using exclusively the plant extract. The results showed that the formation of nanoparticles induced a dark brown color change, accompanied by an absorption peak at 450 nm in the UV‐visible spectrum, specific to nanoparticles. Scanning electron microscopy analysis revealed spherical nanoparticles of approximately 80 nm, and X‐ray spectroscopy confirmed the presence of silver. FTIR analysis identified phenolic compounds (flavonoids, polyphenols) and sugars, responsible for the reduction of silver ions and the stability of the nanoparticles. On the bioactive level, these nanoparticles showed a strong antioxidant and anti‐inflammatory potential, with an activity comparable to the control, without cellular toxicity, as confirmed by cell proliferation tests. These results open new perspectives for targeted therapeutic applications, highlighting the importance of sustainable synthesis methods.
The Push Toward Public Participation in the Governance of Industrial Safety Risks
Authors: Bieder Corinne , Laroche Hervé
Published: January 2025

This introductory chapter first provides a brief overview of the evolution of public participation in risk governance. Initially intended to strengthen accountability and empower citizens, civil society participation is now recognized as a component of decision-making processes in many areas of public life. The emergence of high-risk technologies and facilities has increased public interest in political and industrial decisions, and legislative efforts have been made to promote citizen participation. However, the implementation of public participation varies considerably between contexts and often falls short of expectations. Despite the challenges, there is growing recognition of the need for industrial companies and regulators to engage alongside the public in decision-making processes related to risk governance. This chapter highlights the complexities and contingencies involved in public participation and, as reflected in subsequent chapters, the importance of understanding diverse perspectives and approaches. Finally, in a second section, this introduction provides an outline of the chapters of the book.
Public Participation and the Democratic Imaginaries
Authors: Joly Pierre-Benoit , Bieder Corinne
Published: January 2025

Public participation has significantly developed since the 1980s. While public participation is commonly expected to bring better knowledge, better decision implementation and better democracy, the reality shows that it does not always lead to these benefits. This chapter provides explanations for this discrepancy between expected and observed benefits, by revealing the implicit assumptions and frameworks underpinning the diverse understandings of public participation. It identifies three axes along which these understandings differ. On the basis of this, it suggests a broader look at participation that allows to reach beyond its current flaws.
Decision Making in Projects Involving Public Participation
Authors: Laroche Hervé
Published: January 2025

Public participation in choices involving industrial risks may enrich the choice in many ways, but it also results in more complex, if not messy, decision making. The purpose of this chapter is to offer a general framework to account for the decision-making processes that unfold over time in connection with an industrial project and to situate public participation within these processes. I build on the “garbage can model” of decision-making, a famous and provocative conceptualization that has generated a thread of research in organization studies and political science. Decision making is understood as resulting from the encounters of problems and solutions supported by a number of participants with varying degrees of involvement in the decision. The encounters are regulated by organizational arrangements that filter the flow of participants, problems and solutions. What constitutes a good or bad regulation is discussed in the conclusion.
Konklusion und Systematisierung
Authors: Sehmer Julian
Published: January 2025

Unter der Überschrift „Konklusion und Systematisierung“ leistet dieses Kapitel eine Ordnung der Erkenntnisse aus der Rekonstruktion der untersuchten Eckfälle im vorangegangenen Kapitel. Diese werden dabei nicht mehr vollständig in Bezug auf die einzelnen Eckfälle wiederholt, sondern gebündelt und systematisiert. Herausgearbeitet werden so eckfallübergreifende Strukturen, Muster und Ordnungen des Feldes. Diese Systematisierung der gewonnenen Erkenntnisse bildet in Ergänzung der Forschungsheuristik aus Kapitel 9 das gegenstandsverankerte theoretische Konzept zur Bedeutung und (Re)Produktion sozialer Normen innerhalb der Logik der untersuchten sozialpädagogischen Praxis.
Statt eines Fazits: Beiträge und Begrenzungen reflexiv-zirkulärer Forschung
Authors: Sehmer Julian
Published: January 2025

Den Ausgangspunkt der Beschäftigung mit der kinderschutzbezogenen Handlungs- und Forschungspraxis bildete die Feststellung, dass empirische Studien im Kinderschutz immer wieder ähnliche Defizitdiagnosen produzieren und wiederholt ähnliche Erkenntnisse formulieren. Gefragt wurde, ob dabei nicht möglicherweise systematisch spezifische Aspekte der Praxis ausgeblendet werden, die empirisch nicht weiter aufgeklärt werden können und so auch eine Kontextualisierung und empirische Entschlüsselung feldspezifischer Logiken unterbleiben. Mit der vorliegenden Arbeit und den beiden Teilstudien wurde das Vorhaben unternommen, eine Heuristik zu entwickeln, die es ermöglicht, eine spezifische Fehlstelle in der Beforschung der sozialpädagogischen Kinderschutzpraxis aufzuklären: die Bedeutung und (Re)Produktion sozialer Normen für sozialpädagogische Praxen und Praxis.