bluuebunny/crossref_metadata_2025 huggingface dataset:
Percepción, ampliación y organización de la experiencia en la construcción de fenomenologías
Authors: Montes-Jiménez Juan Pablo , Rivera-Vargas Yuly Hadbleydy
Published: April 2021

Este artículo muestra el desarrollo investigativo sobre el papel de la percepción en la ampliación y organización de la experiencia, así como, de las implicaciones pedagógicas de la postura fenomenológica y prácticas experimentales en el aula para la construcción de explicaciones, específicamente sobre la fenomenología de la audición. La investigación muestra reflexiones en cuanto a lo epistemológico, cuando se elige una ruta de construcción de conocimiento partiendo de la fenomenología como opción para el aula en la clase de ciencias naturales, así mismo, de aspectos pedagógicos y del que-hacer en la clase de ciencias desde una postura experimental no corroborativa, sino enriquecedora de la experiencia del sujeto, que se expresa a través del hablar-se, hablar y actuar, y por supuesto del ámbito disciplinar como espacio de discusión y construcción de explicación de un fenómeno común, pero que pocas veces se somete a reflexión como lo es la audición, este problema de conocimiento, no se inscribe desde ninguna disciplina específica sino se habla desde un contexto no diferenciado de las ciencias naturales, donde se relacionan la fuente, el medio y el receptor como elementos que configuran el fenómeno de estudio.
Osmoacondicionamiento de semillas de Zea mays con extractos vegetales para aumentar el vigor de establecimiento
Authors: Joya Dávila José Gregorio , Ramírez González Sandra Isabel , López Báez Orlando , Jiménez Núñez Sara Azucena del Rosario , Álvaro Alvarado Gaona Álvaro , Espinosa-Zaragoza Saúl
Published: April 2021

Dada la importancia cultural y económica para México del cultivo del maíz, y los efectos sobre la germinación y el desarrollo inicial provocado por malezas, fitopatógenos y condiciones ambientales adversas, el objetivo de esta investigación fue evaluar el efecto del osmoacondicionamiento de semillas de maíz sobre la germinación y el desarrollo inicial. Se realizaron dos ensayos; en el primero se estudiaron los resultados de tres extractos vegetales: Cinnamomum zeylanicum, Azadirachta indica y Zingiber officinale; bicarbonato de sodio y el biofertilizante magro. El primero con once tratamientos en un diseño completamente al azar, en el cual se cuantificó la velocidad de emergencia y el porcentaje de germinación. En el segundo ensayo se estudiaron nueve tratamientos, los cuales consistieron en las concentraciones que permitieron la germinación en el primer ensayo; como variables se cuantificaron altura, peso de materia fresca y seca total, y volumen de raíz. Se utilizaron semillas locales de Chiapas, la siembra se realizó en vivero, utilizando arena de río estéril como sustrato. Las semillas que fueron tratadas con bicarbonato de sodio y C. zeylanicum 10 % (V:V) presentaron mayor velocidad de emergencia; el tratamiento bicarbonato de sodio (30 g/L) favoreció la germinación y junto a los tratamientos C. zeylanicum al 10 % (V:V) A. indica al 20 % (V:V) y Z. officinale al 30 % (V:V) registraron los valores más altos de peso fresco de raíz, peso fresco y seco de biomasa aérea, además estimularon el crecimiento aéreo en un 56 % con respecto al tratamiento control (p<0.05). Los extractos vegetales de C. zeylanicum, A. indica y Z. officinale a concentraciones bajas estimulan el crecimiento radicular y aéreo, e inhiben el crecimiento de hongos fitopatógenos sobre las semillas y raíces al momento de la siembra, mientras que a concentraciones del 100 % inhiben la germinación de las semillas de Z. mayz.
Posgrado en Geografía (UPTC-IGAC): aportes a la disciplina geográfica en Colombia (1984-2019)
Authors: Rojas Corredor Jorge Leonardo
Published: April 2021

En el artículo se reconstruye la trayectoria del Programa de Estudios de Posgrado en Geografía (EPG), producto del convenio establecido entre la Universidad Pedagógica y Tecnológica de Colombia (UPTC) y el Instituto Geográfico Agustín Codazzi (IGAC), a partir del análisis de los trabajos de grado y tesis desarrollados al interior del EPG. Se tomó como principal técnica la revisión documental, perteneciente al enfoque cualitativo, que otorga una mayor profundidad y riqueza interpretativa a la información obtenida. Entre los resultados alcanzados destacan la definición de las principales temáticas, metodologías y enfoques geográficos que han orientado los trabajos de grado publicados por el EPG y que, en cierta medida, llegan a reflejar los intereses y preocupaciones de la disciplina geográfica colombiana en el periodo de estudio 1984-2019. Este tipo de trabajos de carácter historiográfico contribuyen a la sistematización de experiencias que se han venido gestando en nuestro país en el campo geográfico.
Dinámica territorial del extractivismo agrícola y petrolero a comienzos del siglo XXI en el departamento del Meta, Colombia
Authors: Devia Acosta Claudia Yolima , Piñeros Lizarazo Robinzon
Published: April 2021

Este artículo presenta un mapeo de la dinámica territorial de las economías extractivas en una parte de la Orinoquia colombiana considerada como la última frontera agrícola del país. Este mapeo es un insumo para el análisis de la espacialización del extractivismo que considera las transformaciones recientes en las áreas de agricultura campesina y el crecimiento de las áreas de cultivos agroindustriales, así como las nuevas extensiones de monocultivos y de producción petrolera. Estos elementos fueron mapeados y comparados temporalmente, también se analizó el cambio demográfico y, en particular, el acelerado proceso de urbanización de la población en relación con el fenómeno estudiado. Posteriormente, se elaboraron coremas que sintetizan la dinámica espacial y temporal de los extractivismos en el departamento. A partir del análisis se evidencia la dimensión multiescalar del extractivismo y la complementariedad entre la expansión petrolera y agroindustrial en la Orinoquia, en el departamento del Meta y en otras regiones de la escala nacional como resultado de la demanda internacional de commodities.
Educación ambiental desde culturas y territorios en conflictos socioambientales en América Latina
Authors: Kato Danilo Seithi , Pedraza Jiménez Yamile
Published: April 2021

Vivimos un momento histórico que marcará profundamente a la sociedad. En el mismo momento en que escribimos esta editorial para el volumen 12 de la revista Praxis & Saber, tenemos la asombrosa cantidad de 2 236 454 seres humanos muertos por causa de la pandemia generada por el SARS-Cov-2 —covid-19—. Solo en Brasil y Colombia, donde escriben los editores invitados de esta edición, se registran 280 885 muertes, casi dos mil muertes por día en ambos países. Son vidas perdidas que superan las tasas de mortalidad de las grandes guerras en la historia de la humanidad. Confinados o no, desde nuestros dispositivos electrónicos, nos actualizamos a un ritmo acelerado y quedamos incrédulos ante la pérdida de amigos, familiares y líderes locales tradicionales. Fatalmente, cuando se publique este texto, estos números ya serán considerablemente más altos.En muchos estados hay un colapso del sistema de salud y la previsión de camas de UCI se ha vuelto cada vez más escasa.
Pedagogía y formación docente universitaria hoy en Latinoamérica, una visión epistemológica
Authors: Bennasar-García Miguel Israel , Guerrero José Atilio , Zambrano-Leal Newman Yonander
Published: April 2021

El objetivo del estudio es analizar, desde la perspectiva epistemológica, la pedagogía y la formación universitaria en el contexto latinoamericano hoy. El itinerario metodológico utilizado fue la hermenéutica, que permitió la búsqueda de elementos y teorías sobre el tema, lo que sirvió para el posterior abordaje crítico. Se encontró que la formación docente universitaria es vista como una forma heurística, cuya función es enseñar los diferentes contenidos programáticos; y que no existe una visión epistemológica clara en los procesos de formación universitaria. Esto permitió entender que la pedagogía y la formación del docente universitario son ejercicios epistemológicos que enlazan el quehacer docente y la producción de conocimientos. Tratamos de dar sentido a las experiencias de aprendizajes en el aula desde una óptica fenomenológica, al caracterizar los acontecimientos cognoscitivos como la sucesión de la aprehensión de lasexperiencias didácticas, que son fuentes de saber en la evolución educativa. Esta última proviene de las experiencias escolares y singulares, que dan sentido a los eventos pedagógicos de un proceso educativo trascendente y necesario.
Two months of protein–rich dietary recommendations for older patients at risk of malnutrition improves nutritional status, and decreases body fat percentage
Authors: SAVAŞ Sumru , SARAÇ Zeliha Fulden , ÖZDENER Aynur , YILMAZ Merve , AKÇİÇEK Selahattin Fehmi
Published: April 2021

Aim: It is aimed to evaluate the impact of protein – rich dietary (PRD) recommendations on the body composition of older patients at malnutrition risk (MR) in this study.

Materials and Methods: Patients ≥65 years of age, without cognitive problems, diabetes, renal diseases, admitted to Internal Medicine Nutrition Outpatient Clinic consecutively were screened, and 30 patients in normal nutritional status (NS), 30 patients at MR were planned to be enrolled. Body compositions, NS, and anthropometric measurements were performed. Patients at MR were trained for PRD recommendations. Evaluations were repeated in both groups after two months.

Results: Sixty older patients were enrolled (mean age 72.5 ± 6.2; Female / Male: %63.3 / %36.7). After two months; in the group at MR (n = 30); there was a significant decrease in mean body fat ratio (P = 0.036), increase in body water ratio and Mini Nutritional Assessmnet – Short Form (MNA-SF)

score (P = 0.020 and P < 0.001). Mean body weight (BW) , body mass index (BMI), waist – hip circumference, fat mass, fat free mass (FFM) and calf circumference were similar. In the normal NS group (n = 30) mean BW, waist – hip circumference, fat mass, FFM, calf circumference values

significantly decreased (P = 0.001, P = 0.021, P = 0.016, P = 0.025, P = 0.002, P = 0.017, respectively), and BMI, fat ratio, body water and MNA – SF scores were similar.

Conclusion: In the group at MR, PRD recommendations improved NS, and fat ratio decreased. In patients given general nutritional recommendations with normal NS; BW, waist – hip circumference, fat mass, FFM, and calf circumference decreased. PRD recommendations should be given for the care of appropriate older patients.
Sarcopenia prevalence and the quality of life in older adults: A study from Turkey’s east
Authors: EFE Mehmet , SARAÇ Zeliha Fulden , SAVAŞ Sumru , KILAVUZ Aslı , AKÇİÇEK Selahattin Fehmi
Published: April 2021

Aim: Sarcopenia as a geriatric syndrome decreases quality of life and increases functional dependency, hospitalization and mortality. The aim of this study is to investigate the prevalence of sarcopenia among community-dwelling people aged 65 years and older in Muş province and to examine its effects on quality of life.

Materials and Methods: In this study we have interviewed 371 community-dwelling older adults. A total of 186 older adults from the rural area and 185 older adults from Muş city center were enrolled in the study. Data was collected through face-to-face interviews conducted in the participants’ homes by trained researchers. The presence of sarcopenia, socio-demographic characteristics (place of residence, gender, age), presence of chronic diseases, polypharmacy, body mass index, and quality of life with Short Form-36 were determined. Muscle mass, handgrip strength and gait speed were determined for defining sarcopenia.

Results: The mean age of participants was 72.3 ± 6.8 years (65-100) and 46.1% of them were females. The prevalence of sarcopenia was 11.8% among older people residing in the rural area whereas the prevalence was 21.6% among older individuals living in the city center (p = 0.012).

Sarcopenic patients were older, more underweight, hypertensive, and had lower calf circumference, gait speed, and grip strength in males than non-sarcopenic patients (p
Splenic infarction as a rare cause of abdominal pain in older adults: A case report
Authors: DAYLAN Ayşe , ŞAHİN Sevnaz , AKÇİÇEK Selahattin Fehmi
Published: April 2021

Spontaneous splenic infarction has been rarely reported within aged population. The diagnosis of the condition is based on clinical findings and splenic imaging. In recent years, ultrasonography and computed tomographic scan have gained in popularity for the diagnosis of splenic infarction. Most reported cases are focal infarctions, and treatment is mostly conservative. We described the case of a 82-year-old female with cured breast cancer, paroxysmal atrial fibrillation, hypertension who had left upper quadrant pain within 15 days. Physical examination on admission revealed a palpable splenomegaly. Abdominal computed tomography scan showed many subcapsular infarct zones of the spleen measuring 16 cm in length and 4.5 cm conglomerate lymphadenopathies within periportal region. Doppler ultrasound revealed wedge-shaped heterogeneous hypoechoic avascular areas and lymphadenopathies. After laboratory tests, the underlying cause was found as marginal zone

lymphoma. The patient was treated with conservative management and chemotherapy was planned for specific cause. Splenic infarction must be kept in mind for older patients with underlying comorbidities presenting with acute left upper quadrant pain.
Mejoramiento urbanístico y equipamiento comercial - empresarial post panamericanos entorno de la Villa Panamericana en Villa El Salvador
Authors:   , Oliveros Andrade Katherine Melissa
Published: April 2021

El Mejoramiento Urbanístico y Equipamiento Comercial – Empresarial Post Panamericanos entorno de la Villa Panamericana en Villa el Salvador es un proyecto de desarrollo urbano a nivel de Lima Metropolitana ubicado en el distrito de Villa el Salvador, en la provincia de Lima, en el departamento de Lima, específicamente en los lotes colindantes dentro del terreno designado para la reciente Villa Panamericana realizada para los Juegos Panamericanos y Parapanamericanos 2019. Analizando la reciente construcción de la Villa Panamericana y el desaprovechamiento en los espacios de los lotes colindantes del terreno donde se ubica, surge la idea de este proyecto integral para cubrir las actuales necesidades de déficit de comercial, de vivienda y empresarial. Al realizarse los Juegos Panamericanos en cualquier parte del mundo, los países seleccionados para este evento tan importante no solo deben de invertir para ello, tienen la oportunidad de repotenciar el territorio post evento, por ello este proyecto de desarrollo integral genera un eje comercial-empresarial e intervenciones viales en el distrito para mejorar su articulación y conectividad con toda la provincia de Lima. La propuesta principal se enmarca en el diseño de un centro comercial llamado “Mall de Villa” a nivel metropolitano y propuestas complementarias de un centro empresarial, bloques residenciales para viviendas sociales y áreas recreativas. Donde a nivel de propuesta arquitectónica es de carácter sostenible por sus elementos y sistemas constructivos eco amigables y reciclados promoviendo una alternativa de realizar arquitectura sostenible para mejorar el hábitat, calidad de vida y el medio ambiente.
Impacto de una mejora de la gestión de inventarios en el nivel de servicio de una empresa luminaria
Authors:   , Del Castillo Ramos Gianella , Farfán Naraza Carla
Published: April 2021

El presente trabajo de investigación ha sido desarrollado en una empresa luminaria, dedicada a la importación, venta y distribución de tecnología de iluminación LED. Para la empresa en muy importante la relación con sus clientes, sobre todo, en el mercado tan competitivo. De esta forma, y dado el giro del negocio, dentro de los procesos que más generan valor son los correspondientes a la gestión de inventario. En los cuales detectaron diversas deficiencias a corregir. De esta manera, la relación con el cliente resultante del manejo de inventarios es diagnosticada mediante el indicador nivel de servicio, para incrementarlo se planteó una mejora en la gestión de inventarios. Para ello se utilizaron diversas herramientas como son la clasificación ABC, rotación de inventarios, EOQ, stock de seguridad, punto de re-orden, 5S, planes de capacitación y revisión de procesos. Con la finalidad de verificar la hipótesis de la presente investigación con diseño cuasi-experimental, se precedió a evaluar las dimensiones del nivel de servicio, antes y después de la mejora en la gestión de inventarios. Obteniéndose resultados favorables. En conclusión, la mejora de la gestión de inventarios tuvo un impacto positivo en el nivel de servicio. No obstante, cabe señalar, que sin el compromiso de todo el capital humano dentro de la organización no se hubieran obtenido los mismos resultados.
Pharmacological methods of regulation of liver functions
Authors: Vengerovsky A. I.
Published: April 2021

This paper presents the results of comparative study of the therapeutic activity, mechanism of action and combined use of original natural hepatoprotective agents eplir, lochein, macsar, essentiale, and legalon in experimental toxic hepatitis and Reye`s syndrome model.
Cytokines and nitric oxide in case of bronchial asthma
Authors: Petrovsky F. I. , Petrovskaya Yu. A. , Ogorodova L. M. , Serebrov V. Yu.
Published: April 2021

Complex interactions between nitric oxide and cytokines of atopic inflammation are presented. The effects of interleukin-4 on nitric oxide synthesis, immunoregulatory properties of nitric oxide and its influence on Th1/Th2 balance are described.
Today situation of after degree education in the Siberian State Medical University
Authors: Timoshina E. L. , Alifirova V. M.
Published: April 2021

In the article the modern situation of the post degree courses of the medical workers in the Siberian State Medical University are presented, also the problems of the post degree medical education and the achievements of SSMU in this sphere of this activity are considered and pointed out.
Gastroenteric Tract Functional Diseases
Authors: Beloborodova E. I.
Published: April 2021

The modern view on the problem of the disorder of stomach is presented that is very important for working out the treatment for this category of ill people.
The strategy and educational conception in medical library
Authors: Kazantseva N. V.
Published: April 2021

In the article the strategy of the library- informational provision of the education for the satisfaction of the workers and the students of the university in the changing conditions of informing and automation is presented.
Lavrova Valentina Stepanovna
Authors: Vladimirova T. N.
Published: April 2021

The author of this article describes some directions in the development of the Tomsk Scientific School of Pathophysiologists (1939–2001) by the description of the life of V.S. Lavrova, the teacher and the researcher of Pathophysiology Department. In the work her private memories, the memories of her students and colleagues, the archive materials are used. Some of them are published for the first time.
Structural-functional changes of lymphoid organs under vibration and their correction with the help of essencial phospholipides
Authors: Bobrova S. V. , Efremov A. V. , Vakulin G. M.
Published: April 2021

The research of lymphoid organs of male rats of Vistar line wich were subjected to vibration with freguency of 32 Hz during 30 days has been conducted. Cytological shifts of the basic structural components of the investigated organs during the vibration period, postcontact rehabilitation period (30, 60 days) and under essencial phospholipides correction were estimated by the methods of light and electron microscopy and morphometry. The analysis of the obtained data demonstrated that the important infringement of lymphoid organs structures takes place. The dynamic study of morphofunctional and ultrastructural changes, cytoarchitectony of parenchymatous stromal compartment gives evidence of the development of degenerate-distrophic processes with mainly involutional character. Pharmacological correction resulted in positive dynamic of cytological shifs and helped to rehabilitation the natural cell phenotype.
The Сharacter and Development of photoreceptors photodegeneration combined with alloxan diabetes
Authors: Logvinov S. V. , Varakuta E. Yu. , Potapov A. V.
Published: April 2021

The aim of the research is to determine the character and development of a alterations in photoreceptors, caused by high-intensity light on the early stage of diabetes mellitus. The methods of light and electron microscopy were used. Experiments were obtained from 80 adult white male rats. The rats of group 1 (n = 20) received 1 injection of alloxan (15 mg per 100 g of weight) in order to model diabetes mellitus. The rats of group 2 (n = 20) were exposed for light of luminecent LB-40 lamps (6000 lx) for 6 hours. The rats of group 3 (n = 20) were exposed to the light with the same parameters 1 month after alloxan injection. The last 20 rats made a control group 4. The rats groups 2 and 3 were sacrifised by decapitation 1, 7, 14, 30 days after the light exposure, the rats of group 1 on the 4, 5, 6, 8 week after the alloxan injection. Light exposure combined with diabetes causes destruction pigment epithelium inner and outer processed of photoreceptors followed by pyknosis of nucleus and replacement by vacial glia. On the 7th day after the exposure local disappearance of according retinal layers was obsevred. In these local sites of the most intensive destruction in group 3 there is 1,6 times more cells with caryopyknosis from in according sites of group 2 (just light exposure) rats. Thus, alloxan diabetes on the early stage of its development (1 month) intensifies light damage of retinal photoreceptors. Probably, increase of oxydative processes and antioxidative systems break down play an important role in this synergetic effect.
The new forms of organization of the exit medical help to the inhabitants of boreal districts of Siberia
Authors: Solomatina T. V. , Kapilevich L. V.
Published: April 2021

Alongside with economic problems of development of North the important place is borrowed by a problem of guarding of health of the population. The population of Boreal districts of Siberia is subject to effect of a lot of the unfavorable factors both connatural (climatic conditions), and anthropogenic (ecological trouble) character. A corollary it is the high level of a case rate, violation on the part of cardiovascular, nervous and other systems of an organism. The inhabitants of boreal districts, workers of oil-extracting branch are bunch of the boosted risk on creation of a pathology of organs of a circulation and endocrine system. The data quota needs a regular control of a state of health and opportune rendering of a medical care in amplate volume. The optimal form of organization of a medical care to the population of Boreal districts is the direction of exit medical crews in items of their residing. Such form of work is economically favourable and at the least expenditures allows to reach appreciable social and medico-sanitary effect.
Anatomical pathology department of Siberian State Medical University. Toroptsev I.V. (1907—1985) to 95th jubilee
Authors: Ordina O. M. , Borisova G. V. , Paderov Yu. M. , Nedosekov V. V.
Published: April 2021

Biography of the great scientist-pathologist, professor of Tomsk medical institute (Siberian State Medical University at present) I.V. Toroptsev — one of the founders of radio- and magnetobiology.
Mechanisms of metabolic brain disturbances after acute fatal blood loss
Authors: Dolgikh V. T.
Published: April 2021

In the course of experiments in 210 white mongrel male rats, endured 5-min clinical death from acute blood loss the mechanisms of energy, carbohydrate, lipid metabolism disturbance in postresuscitated brain tissue have been studied. It has been established that primary and secondary hypoxia, metabolic acidosis, excessive lipid peroxidation process activity, endotoxemia, neuron overload by Ca ions appeared to be the principle pathogenetic factors of the abovementioned disturbances. Pathogenetic block-scheme of early postresuscitation metabolic disturbances in brain was presented. The validity of this block-scheme principle theses was demonstrated by means of gutimin antihypoxanths (50 mg/kg) and sodium γ-hydroxybutyrate (300 mg/kg), ionolantioxidant (100 mg/kg), slow isoptin Ca-canals blocker (0,1 mg/kg) injected before clinical death.
The employment of polyphenol complexes extracted from Pеnthaphylloides fruticosa (L.) O. Scwarz for prophylactic of Coxsackie-virus infection
Authors: Evstropov A. N. , Burova L. G. , Greck O. R. , Zakharova L. N. , Volkhonskay T. A.
Published: April 2021

In the present work the antiviral activity of water extract, received from Pеnthaphylloides fruticosa (L.) O. Scwarz, against Enteroviruses Coxsackie B (CVB) was studied. The maximal intoxic dose of the preparation for the cell-culture (CC) Нер-2 was 1500 mg/ml. It was found, that a preliminary processing of the CC by substance 24 hours before the virus contamination suppresses the virus reproduction in minimal inhibition doses 31 mg/ml — for CVB1-5 and 63 mg/ml — for CVB6. After that, the prophylactic action of the water extract against CVB3 was showed in experimental infection in newborn mice. It maximal intoxic doses for BALB/c mice is 100 mg/kg. The scheme with the preliminary inoculation of pregnant mice by 40 mg/kg of water extract within 3—5 days and following contamination of new-born animals by 100 DLM of virus, showed positive results: increase percent of survival and average life duration, improving of weight dynamics, decrease of virus accumulation level in tissues of brain, liver, heart. The received results determine good prospects for further investigation of water extract from Pеnthaphylloides fruticosa as prophylactic antiviral remedy.
Airway hyperresponsiveness in bronchial asthma: pathogenesis basics
Authors: Deyev I. A. , Petrova I. V. , Karmalita E. G. , Petrovsky F. I. , Ogorodova L. M.
Published: April 2021

Bronchial asthma has three main components: persistent bronchial inflammation, reversible bronchial obstruction and bronchial hyperresponsiveness to nonspecific triggers. Airway hyperresponsiveness is a complex phenomenon that develops upon the influence of chronic inflammation, high total IgE, changes in bronchial smooth muscle cells functioning, structural changes in bronchial wall and disturbances in neural regulation of bronchial tone.
Clinic-epidemiological research of reproductive health of city and country population in Tomsk region
Authors: Radionchenko A. A. , Philippov O. S.
Published: April 2021

There were presented the results of single-stage epidemiological research in methology World Health Organization the aim of which was to evaluate the influence of some factors on fertility of city and country female population. Among 2545 women who filled in forms and live in a city (2000) and country (545), 16,4% and 17,0% are sterile. Secondary sterility prevails primary one. The main reasons of sterility are infectious diseases of pelvis minor organs, abortions, abnormality of menstrual cycle, miscarriages and contraception.
Efficiency of postoperated microwave therapy of the patients with inflammated tubo-ovarian tumors
Authors: Evtushenko I. D. , Romanova A. P.
Published: April 2021

The aim of the research is the study of efficiency of early postoperative rehabilitation of patients with purulent inflammatory formations of uterine appendages with microwave therapy. Postoperative treatment of 36 women-patients with the use of combined skin and intravaginal microwave exposure was done. The clinical characteristics of postoperative period and the results of the therapy in 18 month were studied. Dynamical changes of quantitative characteristics of cells at leukemia, of C-reactive protein, content in blood serum, in cervical canal and endometrium of tumor necrosis factor-alpha, interleukin-1 beta and interleukin-6 were estimated. If comparing with the patients who didn’t get physiotherapy exposure the use of microwave therapy at the patients with purulent tubo-ovarian formations was followed by earlier disappearance of inflammation, restoration of quantitative characteristics of leucocytes in blood, normalization of C-reactive protein concentration in blood serum and normal characteristics of erythrocyte sedimentation rate. Diminution of tumor necrosis factor-alpha in blood serum, interleukin-1 beta and interleukin-6, reduction of concentration in cervical canal and endometrium interleukin-6 were observed. In the postoperative period under the microwave therapy womenpatients had pain in pelvis, disturbance of menstrual cycle, 26,5% of women had the reproductive function to be restored.
The use of marketing methods in the medical library work
Authors: Molodtsova N. V. , Terekhova M. V. , Terekhova M. V.
Published: April 2021

Application of marketing approaches in the Scientific Medical Library of the SSMU. The use of additional financial assets for library development. Informational and promotional activities. Library work on the formation and perfection of the image.
Sarcoidosis of lungs in a child aged 12
Authors: Mayevskaya Z. A. , Luchinina R. N. , Badjina O. S. , Rodionova O. V.
Published: April 2021

The clinical observation of 12-year-old patient with sarcoidosis is described. This disease is extremely rare in children. Initially pneumonia was diagnosed in a boy, then the necessity of conducting of differential diagnostics between sarcoidosis and tuberculosis was appeared. The final diagnosis-sarcoidosis of lungs was diagnosed on the basis of comprehensive clinical and laboratory examination taking into account focus-infiltrative changes in lungs, intoxication, involvement of T-immunity system and also revealing of granulomas by morphological study of biopsy material, having distinctive characteristics typical for sarcoidosis.
Exogenic and endogenic factors in chronic obstructive pulmonary disease forming
Authors: Bukreeva E. B. , Bogushevich S. A. , Dementieva E. A. , Chernogoryuk G. E. , Nesterovich S. V. , Seitova G. N. , Buikin S. V.
Published: April 2021

To determine the role of exogenic and endogenic factors in chronic obstructive pulmonary disease (COPD) forming 100 patients (50 patients are control group) were examined by means of clinical and genealogical researches, including family tree composition with analisis of 3—4 generations, genotyping on the most wide-spread α1-proteinase inhibitor (α1-PI) gene alleles (M, S, Z), definition of the α1-PI level in the serum. The role of exogenic factors (smoking, pollutants) have been confirmed in COPD forming, while primery α1-PI deficiency have been revealed only in 6% COPD patients. Therefore, further investigations of other genetic alleles in COPD patients are necessary.
The effectiveness of the usage of magnetolazer in the complex therapy at the patients with pelvic inflamatory desease
Authors: Yalovega Yu. A. , Voronovskaya N. I. , Tkachev V. N. , Gaifoulina Zh. F. , Titkova I. N. , Evtushenko I. D.
Published: April 2021

For more effectiveness of pelvic inflamatory desease treatment there were observed 61 patients with different forms of this patology and saggested a new complex method of treatment, including the usage of magnetolazer therapy after endoscopical organokeeping operations in early after operation period. The dynamics of proinflamation citokins change content (interleikin-1 beta and alfa tumor necrosis factor) in blood serum of patients with pelvic inflamatory desease confirmed the effectiveness of magnetolazer therapy. Resalts of the invesnigation proved that saggested complex method of treatment for patients with pelvic inflamatory desease allows to make organokeeping operations for reproductive women and to improve results of treatment.
Paradocsis’ of clinical thinking (continuation of the discussion started in Tomsk by Osipov I.N., Kopnin P.V. in 50th of the 20th century)
Authors: Kaznacheev V. P.
Published: April 2021

Considering the necessity to study the problems of propaedeutics of clinical medicine, besides the well-know syndromes by which the clinical diagnosis is formed, there are nosological syndromes of tiredness in which the changes of inner and outer environment are taken into account:

1) non-liminal outer ecology,

2) endoecological syndrom of tiredness,

3) coagulopathy,

4) syndrom of custom.

Diagnostics of these syndromes makes it possible to form a new clinical diagnosis taking into account the changes of inner and outer environment which lead to genetic default and endoecology phenomenon.
Causes of diagnostic pitfalls upon analysis results of «physicians’ causes»
Authors: Osipov A. I. , Bunin Yu. N. , Kladov S. Yu. , Sokolov A. S. , Shnayder A. D.
Published: April 2021

130 criminal and civil cases had been maintained against physicians in Tomsk region within 1996—2002. There were pitfalls in diagnoses and wrong medical aid in 59 (45,4%) cases. Across diagnostic pitfalls, such as incomplete examination of patients, incomplete registration of laboratory results etc., there were methodological errors. It is known that diagnosis process proceeds in hypothesis form at all stages. While obtaining the history a physician is guided by suppositions arising during inquiring a patient. These suppositions are later verified in the process of an objective examination of the patient. Therefore the most frequent reasons of medical errors are the final diagnosis on the basis of the history and physicians’ inability to use the diagnostic suppositions while diagnosing at all stages. The majority of pitfalls has been made in diagnoses of appendicitis, stomach and duodenum perforated ulcer.
Symptom as an initial point at diagnosis
Authors: Lavrova V. S.
Published: April 2021

Ascertainment of disease symptoms is an extremely important stage in diagnostics process. Errors committed at this investigation stage may contribute in wrong interpretation of disease and inadequate treatment.
Therapeutic approach to children’s intussusception at late hospitalization
Authors: Belyaev M. K. , Fyodorov K. K.
Published: April 2021

The goal of the investigation was to define whether conservative disinvagination would be safe and effective for long children’s intussusception. 368 children of 1 month to 13 years old age with intussusception have been treated in Novokuznetsk’ pediatric surgery clinic for a period from 1976 up to 2001. The number of boys was 248 (67,4%) and girls — 120 (32,6%) respectively. Patients of the age up to 1 year old were 185 (50,3%), older than 1 year — 183 (49,7%). 214 patients (58,2%) were hospitalized during the first 12 hours from the disease began, 71 patients (19,3%) — during 12—24 hours, 48 patients (13%) — during 24—48 hours, 35 patients (9,5%) — after 48 hours. In our clinic the method of conservative intussusception therapy is considered to be the priority and its application, if there are no any abdominal cavity complications (peritonitis), does not depend on introducing form, patients’ age, time period of hospitalization following the disease or recurrence beginning. The bloodless therapy has been found to be effective: the 1th stage — 93,2%, the 2nd stage — 93%, the 3d stage — 86,4% and the 4th stage — 91,7%. Thus, our facts earnestly prove both the potential of bloodless intussusception treatment method for children at late hospitalization (after 24 hours) and its safety and high efficiency (88,3%).
Assessment of bone tissue architectonics with digital analysis of computed tomograms for osteoporosis diagnostics
Authors: Kilina O. Yu. , Zavadovskaya V. D. , Danilchuk R. V. , Tretyakov Ye. M. , Rodionova O. V. , Baranova O. V.
Published: April 2021

Digital analysis potential of lumbar vertebra computed tomograms as a method of osteoporosis diagnostics has been investigated. Specific software designed for mineral weight and bone structure assessments has been developed. This software has been approved during the investigation of 10 lumbar vertebra anatomic preparations and 20 patients with chronic renal failure treated by hemodyalisis. Result comparison of computed tomogram digital analysis, mineral structure investigation and histomorphometry of lumbar vertebra anatomic preparations showed that the developed method allowed to perform a reliable analysis of trabecular bone structure and indirect assessment of mineral density.
Model of economic-financial development of a non-state dental clinic
Authors: Kopasov Ye. A.
Published: April 2021

The main task of non-state dental clinics is an active promotion of its’ services in the market. This thesis determines the typical models of market behavior. However, the making of dental service market is accompanied with a number of problems and their solution is a most important task of non-state dental clinic managers. The development of dental clinics in modern conditions requires significant financial investment — into the purchase of building or facilities, purchase of modern equipment and staff training as well as advertising. Attracting of investment or long-term bank credits becomes the barest necessity. Forming of clinic attractiveness for investment for clinic development should be realized on the base of competent business-plan elaboration of a clinic development that demonstrates evidently the specific advantages of the project, the degree of risk, payback and profitability.
Psychotherapy in Siberia: prospection from the past
Authors: Semke V. Ya.
Published: April 2021

In the article there are cited the historical data on psychotherapy development in the east region of the country, mentioned the main stages of psychotherapeutic service perfection in Siberia, outlined the ways of organizational, clinical-dynamic and preventive approaches for the nearest and further prospects of scientific and practical psychotherapy making as a base of creation of a healthy and harmonious individual and social relations.
The use of «Erectron» apparatus after fallopian tube surgery
Authors: Diamant I. I. , Radionchenko A. A.
Published: April 2021

In order to increase the efficiency of surgery at fallopian tube pathology there has been proposed a method of medical rehabilitation with the use of «Erectron» apparatus (autonomous electrical stimulator of gastrointestinal tract — AES GIT). In 1998—2002 in Tomsk Research Institute of balneology and physiotherapy 100 women at the age of 18—39 (26,3 ± 4,1) have undergone a cure with «Erectron» AES GIT. Postsurgical period has been 2,9 ± 0,2 months. After the course of electrostimulation there has been registered an improvement of gynaecological state, blood circulation and functional activity of fallopian tubes. Efficiency of treatment immediately after the treatment has been 84%. Pregnancy beginnings after 18 months — in 39% cases (control — 15%). The proposed method is simple, safe and easy of use and access. It can be used in physiotherapy departments and at the absence of such — as a little physiotherapy — in postsurgical room, medical assistant’s post and rural hospital.
Аntithrombotic prophylaxis and therapy in oncology
Authors: Barkagan Z. S. , Shilova A. N. , Khodorenko S. A.
Published: April 2021

In the article the authors revise a number of methods used in clinic for the description of hypercoagulation syndrome and consider that persistent trombinemia signs and signs of platelet hyperaggregation with the increased consumption of them are the most reliable markers of hypercoagulation and prethrombosis state. Methodology of oncothrombosis prophylaxis and therapy is discussed. Authors demonstrate that heparin therapy decreases the risk of development of spontaneous and postsurgery thrombosis as well as of DIC-syndrome in cancer patients. Authors define the ways of further optimization of thrombotic complications prophylaxis and therapy using thrombine inhibitors and the study of their effects on oncogenesis.
Clinical and endoscopic peculiarities of gastroesophageal reflux disease during bronchial asthma combined with chronic opisthorchosis
Authors: Chernyavskaya G. M. , Beloborodova E. I. , Plekhanova Ye. V. , Degtyaryov S. D.
Published: April 2021

The results of the study of gastroesophageal reflux disease (GERD) clinico-endoscopic peculiarities in 318 patients with bronchial asthma (BA) of different severity degree, combined with chronic opisthorchosis or without it, have been cited in the present article. It has been revealed an often incidence of GERD in BA patients and GERD frequency increased as the disease severer. At that the GERD clinical manifestation have been observed more frequently than the reflux-esophagitis had been discovered by endoscopic ways. GERD structure during BA has been presented. More frequent GERD with BA combined with chronic opisthorchosis has been discovered than in patients without associated parasitic invasion.
Immune and functional states of lymphocytes in different clinical variants of physical growth and development retardation at children and teenagers as a result of immune-endocrine correlation
Authors: Saprina T. V. , Kravets Ye. B. , Ogorodova L. M.
Published: April 2021

For the study of hormonic-immunologic correlation a clinical model has been chosen that included two variants (somatotrophic deficiency and constitutional growth and pubertate inhibition) of physical growth and development retardation at children and teenagers. It has been revealed that immunologic changes under these dwarfism variants were of different character that reflected the hormonic effects on immunity parameters.
Effect of sodium nitroprusside on parameters of electrical and contractile activities of lower esophageal sphincter unstriped muscles
Authors: Stalbovsky A. O. , Studnitsky V. B. , Medvedev M. A.
Published: April 2021

Investigations of electrical and contractile activities of lower esophageal sphincter unstriped muscles under sodium nitroprusside impact have been fulfilled by the method of double sucrose gap. Effect of nitric oxide donor on potassium and calcium membrane conductance has been evaluated, as well as the role of intracellular NO-synthase. Membrane hyperpolarization and contractile activity decrease during the use of sodium nitroprusside and L-NAME have been observed. Conclusion has been drawn of NO effect on potassium membrane conductance as well as of the possible effect on contractile proteins and activation of cAMP-dependent regulation of LES UM physiological functions.
Morphology of internal thoracic and radial arteries at patients subjected to coronary artery bypass grafting
Authors: Mamchur S. Ye. , Vechersky Yu. Yu. , Fadeyev M. V.
Published: April 2021

Peculiarities of internal thoracic and radial artery morphology (ITA and RA) have been investigated by light microscopy in continuous sampling of 10 patients subjected to coronary artery bypass grafting. The object of investigation has been ITA and RA segments marked out during the surgery, fixed in formalin and colored by hematoxylin and eosin. As a result it has been found that the frequency of ITA and RA intima thickening was 28,1 and 20% of cases respectively in CABG candidates. The ratio of intima-media thickness in RA was 2,5 times higher than in ITA. This ratio in distal parts of ITA was 2,3 times higher than in proximal ones and 1,7 times higher than in middle ones. This fact is evidence of the need to decline the use of ITA distal segment in case of enough ITA length.
About a pure soul, a teacher and a friend (to the memory of A.S. Zinovyev)
Authors: Fyodorova G. B.
Published: April 2021

In 2003 went away from life Anton S. Zinovyev corresponding member of the Academy of Medical Science of Russia, Honoured Scientist of the Russian Federation, Professor. In the paper author makes an attempt to show the personality of famous Russian scientist-pathological anatomist.
Possible role of transforming growth factor β as a marker cytokine of type 3 T-helpers in atopic dermatitis pathogenesis
Authors: Pronina N. A. , Sviridova V. S. , Denisov A. A. , Klimov V. V. , Kologrivova Ye. N.
Published: April 2021

The role of transforming growth factor β (TGF-β) in atopic dermatitis pathogenesis is discussed basing on the analysis of existing data of cellular and molecular mechanisms of allergic inflammation. Up-to date data of the main T-helper (T-h) lymphocyte subpopulations including Tx1, Tx2, Tx3 has been presented. Functions of regulatory T-cell populations and produced cytokines have been described. The main attention has been accented on the TGF-β structure and biological activity as a main Tx3 cytokine. The current information of TGF-β influence on different cell populations and its biological activity realization mechanism is thoroughly discussed. Information relating to the mechanism of cytokine regulation during atopic dermatitis has been summarized. A deep analysis of possible participation of TGF-β in disbalance formation on Tx1 and Tx2 levels, in disturbances of histological derma structure and allergic inflammation timing has been made.
Contribution of P.N. Lashchenkov (1864—1925) to the formation of medical-sanitary service in Tomsk city (to the 400th anniversary of Tomsk city and to the 140th anniversary of P.N. Lashchenkov)
Authors: Zakharova G. V. , Kharitonova Ye. M.
Published: April 2021

In the article there has been presented a biography of an outstanding Siberian hygienist, professor of Tomsk Emperor’s University P.N.Lashchenkov, a history of organization of Medical-sanitary Executive Committee in Tomsk city and of the creation of one of the first medical periodical edition «Medical chronicle of Tomsk city». A brief review of the most important for Tomk history publications has been presented.
Modern nosoareas of tick-borne encephalitis and tick-borne rickettsiosis in Siberia
Authors: Yastrebov V. K.
Published: April 2021

Natural centers of tick-borne encephalitis and tick-borne rickettsiosis diseases are distinguished not only by stability and in- creasing level of epidemiological manifestation but also by ability to enlargement of areas. It is found that a contribution of some regions of Russia to the sick rate of tick-borne encephalitis and tick-borne rickettsiosis is changing in time. For tick-borne encephalitis the contribution of East Siberia increases and becomes equal to one of Ural area. For tick-borne rickettsiosis the general contribution of four regions (East Siberia, West Siberia, Ural and Far East) amount to 92% of diseases in country. The greater part of tick-borne rickettsiosis diseases (62,1%) is the contribution of East Siberia because of activi- ty of disease centers of Altai area.
Genetic diversity of East European and Asian strains of tick-borne encephalitis virus belonging to Siberian genotype
Authors: Karan L. S. , Pogodina V. V. , Frolova T. V. , Platonov A. Ye.
Published: April 2021

We have studied 40 strains of tick-borne encephalitis virus attributed to Siberian genotype. The fragment of E gene (211 nt) has been sequenced for all strains. Futher analysis has evidenced the formation of two clusters. One of them includes the strains of East European (EE) origin, the other comprises the strains of Asian origin (A). 17 of 20 East European strains have histidin (H) in amino acid position 234 of gene E, the remaining 3 have either glutamine (Q) or tyrosine (Y). 13 Asian strains have histidine and 7 Asian strains have glutamine in amino acid position 234.
The world areal of Crimean-Congo hemorrhagic fever virus
Authors: Smirnova S. Ye.
Published: April 2021

Distribution of Crimean-Congo hemorrhagic fever (CCHF) virus based on virus isolations and results of seroepidemiological surveys. The were investigated 147 cases of ill (4 countries of Europe and Asia), immunological status of population (13 countries of Europe, Asia and Africa) and domestic animals (16 countries of Europe, Asia and Africa) and infected ticks (7 countries of Eu- rope and Asia). CCHF was first recognized in Azerbaijan, Armenia, Afghanistan, Iran, India and confirmed in Russia, Ukraine, Bulgaria, Yugoslavia (Europe), Uzbekistan, Tadzhikistan, Turkmenistan, Kazakhstan (Asia) and Uganda, Senegal, Kenya (Africa).