bluuebunny/crossref_metadata_2025 huggingface dataset:
Diseño de una bebida a base de Solanum betaceum Cav. (tomate de árbol) y cascarilla de Theobroma cacao L(cacao)
Authors: Matute Castro Nubia Lisbeth , Campo Fernández Mercedes , Vivanco Carpio Erik Ricardo , Escobar Coello Wendy Michelle , Bravo Bravo Verónica Patricia
Published: March 2023

La búsqueda de fuentes de sustancias antioxidantes, que pudieran ayudar a prevenir el estrés oxidativo, es un reto para la comunidad científica. Solanum betaceum Cav y Theobroma cacao L, son materias primas endémicas de Ecuador, a las que se les atribuye propiedades antioxidantes asociadas, fundamentalmente, a su contenido en compuesto fenólicos.

El estudio tuvo como objetivo, diseñar una bebida a base de tomate de árbol con cascarilla de cacao, para obtener un alimento sensorialmente aceptado y con propiedades antioxidantes. Las formulaciones a evaluar se plantearon mediante un diseño de bloques, considerando como variable respuesta, la aceptación sensorial y como variables independientes tres niveles de cascarilla y goma xantana. La formulación de mayor aceptación (I), logró incluir 1 % de polvo de cascarilla de cacao con 0,05 % de estabilizante. El análisis físico-químico de la mejor formulación evidenció un aporte de 5,64 mg de vitamina C y 72,6 mg de fenoles totales, equivalente a ácido gálico por cada 330 mL de jugo. Su capacidad secuestradora de radicales libres fue del 81% expresado como porcentaje de inhibición frente al radical libre DPPH. Los resultados sugieren que esta bebida es una opción beneficiosa para el consumidor debido a su capacidad antioxidante.
Mantenimiento óptimo basado en condición para un generador sincrónico utilizando algoritmo predictivo de desgaste de equipos.
Authors: JIMENEZ VARGAS GEOVANNY , ENDARA VELEZ IVAN DAVID
Published: March 2023

En la actualidad, una buena planificación del mantenimiento es de trascendental importancia en los sistemas de generación ya que la detección eficiente y anticipada de fallos que puedan presentase en los mismos terminan convirtiéndose en un verdadero desafío para las empresas generadoras. El presente artículo plantea políticas de mantenimiento optimo utilizando una arquitectura de mantenimiento basado en condición (CBM) para un caso de estudio basado en un generador sincrónico, las cuales son posibles de definir mediante el índice de degradación estimado que presenten los diferentes componentes del generador sincrónico. Los resultados obtenidos demuestran que el modelo propuesto es capaz de proponer una política acertada de mantenimiento optimo relacionando la severidad de daño del componente con el costo promedio de mantenimiento.
Pasado, presente y perspectiva del bioetanol en Ecuador
Authors: Macias Mendoza Ana Madelaine , Pérez Parra Jean Carlos , Torres Puentes Julio César
Published: March 2023

Desde 2010 en Ecuador se estableció como política energética la utilización de gasolina con 10% de bioetanol, esto en favor de la reducción de emisiones de gases de efecto invernadero; sin embargo, hasta la fecha se comercializa gasolina con 5% de bioetanol solo en ciertas provincias del país. El objetivo de este estudio fue evaluar el desarrollo de la industria del bioetanol en Ecuador en la última década y su perspectiva hacia el futuro, para ello se presenta el marco legal sobre biocombustibles en el país, así como un análisis de datos e informes de la empresa EP Petroecuador que determinan la trayectoria de la industria del bioetanol en el país entre 2010 y 2020, además se realizó un análisis bibliográfico de diferentes estudios realizados sobre la obtención de bioetanol a partir de diferentes materias primas, así como de pruebas de funcionamiento realizadas en vehículos de diferentes marcas con gasolina Ecopaís. Con base en la información revisada, se concluyó que Ecuador puede optar por otras materias primas para la producción de bioetanol, siguiendo experiencias de otros países, para de esta manera poder cumplir con el objetivo de proveer a todo el país, gasolina con un 10% de bioetanol.
EL EL MODELO DE TOULMIN COMO ESQUEMA DE MOTIVACIÓN PARA CUMPLIR LOS PARÁMETROS DE ADMISIBILIDAD EN LA ACCIÓN EXTRAORDINARIA DE PROTECCIÓN
Authors: Acuña Andrés
Published: March 2023

La presente investigación centra sus esfuerzos en el análisis de la sentencia ecuatoriana N ° 1967-14-EP/20, emitida por la Corte Constitucional del Ecuador, la cual infiere de forma específica en la aplicación del Modelo de Toulmin como factor predominante en los requisitos que deben contener las demandas de Acción Extraordinaria de Protección para su debida admisión en el máximo organismo. La metodología empleada se apega a un orden de tipo teórico – descriptivo de tipo documental, donde las bases doctrinarias empleadas determinan la estructura del documento, De manera final, para brindar una dimensión práctica a la investigación, se llevó a cabo la propuesta del esquema que se plantea para la correcta argumentación de la Acción Extraordinaria de Protección en el Ecuador, buscando mejorar el ejercicio de los profesionales del Derecho en el Ecuador. En conclusión, el Modelo de Toulmin se presenta como una lógica pero no tradicional, y se reconoce como un procedimiento de origen más práctico, operativo o aplicado en el que se puede tomar la jurisprudencia como fundamento objetivo, dejando de lado la esencia matemática convencional.

Palabras clave: Admisibilidad, Acción Extraordinaria de Protección, Corte Constitucional del Ecuador, Modelo de Toulmin, Sentencia N ° 1967-14-EP/20
Modelización de un biorreactor discontinuo para lixiviar residuos eléctricos y electrónicos en Guayaquil, Ecuador
Authors: Ortiz María Antonella , Garcia Lizeth , Culcay Mishelle , Sánchez Jefferson
Published: March 2023

The use of electrical and electronic equipment (EEE) has increased considerably worldwide, generating large amounts of waste electrical and electronic equipment (WEEE) of which only 17% is treated. The processing and extraction of metals from printed circuit boards (PCBs) of WEEE is done by a combination of physical and chemical methods, which become highly polluting. Therefore, it is necessary to formulate new eco-friendly strategies to prevent the impact of environmental pollution. The present research proposes to design a Batch bioreactor for the recovery of Cu from WEEE. For this purpose, equations of the modeling of a Batch bioreactor were coupled with real parameters and values taken from the city of Guayaquil and then designed using these values in the AutoCAD design software. A bioreactor was obtained with an optimal agitation considering 8 flat blades for mixing, also the appropriate material is stainless steel, and the optimum working temperature is 28°C. Applying these parameters, a Cu recovery of 96% is obtained in the city of Guayaquil.
Biodegradación del plástico con larvas de insecto Tenebrio molitor como contribución interdisciplinar a la biotecnología a la biotecnología medioambiental
Authors: Cunguan Jomely , Rojas Lizbeth , Morocho Tatiana , Arcos Betsabe , Ortoz Caroline
Published: March 2023

Pollution is the greatest human impact on the planet, that is, the environment is made up of natural and artificial elements, their physical, chemical, biological, social and cultural activities and their respective relationships. The objective of this investigation was to analyze the biodegradation of plastics, from larvae of the Tenebrio molitor beetle, as a contribution to the teaching of environmental biotechnology. Basically, the execution of this project was based on 3 stages. The characterization of Tenebrio molitor larvae, the rearing of the larvae and the quantification of the capacity to biodegrade plastic. The results obtained were, they found that sample 1 (M1) had a specific biomass productivity of 6.6 grams while sample 2 (M2) a specific productivity of 2.3 grams was recorded and managed to show a change in terms of color and the amount of feces. Finally, the biodegradation of polystyrene influences the production of compost, benefiting the consumption of plastic.

keywords : Biodegradation, Plastic, Tenebrio molitor, Environmental biotechnology, larvae.
Perspectivas de comercialización de cerveza artesanal como producto gastronómico en la ciudad de Manta, Ecuador.
Authors: Velásquez Campozano Manuel Rolando , Montilla Pacheco Argenis de Jesús , Cevallos Barberán Leydy María
Published: March 2023

En el sector turismo existe una amplia variedad de productos gastronómicos que forma parte del conjunto de alimentos y bebidas que se ofertan en un determinado destino. Los consumidores, ante esa diversidad observan muy bien las características del producto que desean adquirir, incluso en bebidas de alto consumo, como la cerveza. El objetivo del presente estudio fue identificar las perspectivas y potencialidades que tiene la cerveza artesanal entre los turistas y los residentes de la ciudad de Manta, para ello se realizó una encuesta a una muestra conformada por 334 individuos de diferentes edades. Los resultados revelan una perspectiva favorable acerca de las posibilidades de incorporar la referida bebida como parte de la oferta gastronómica local, así como importantes niveles de exigencia del cliente en cuanto a la calidad y presentación del producto. Se concluye que la cerveza artesanal tiene buena aceptación entre el grupo de sujetos que fueron encuestados.

Palabras clave: cerveza; consumo; encuesta, gastronomía; Manabí
La litigación penal oral en la defensa técnica del procesado en delitos de microtráfico de drogas
Authors: Balladares Carmen , Gavilanes Domínguez Christian Danilo
Published: March 2023

El problema se configura porque hay insumos teóricos y doctrinarios, que se pueden aplicar a la defensa y que versan específicamente sobre el delito de tráfico de drogas en mínima escala, como es el caso de la atipicidad por el incumplimiento de los elementos objetivos del tipo penal, las causas de exclusión de tipicidad o error de tipo, inclusive causas de exculpación. Al no tomarse en cuenta estos insumos, no se podría asesorar efectivamente a la persona procesada, con relación a las ventajas o desventajas para que se someta al procedimiento abreviado, esto lleva a que no permite configurar una defensa técnica eficiente para que los defensores y/o abogados en libre ejercicio, puedan desenvolverse en la dinámica de la litigación penal. El objetivo principal del presente análisis se enmarca bajo la consigna de establecer al Modelo de defensa estratégica de litigación penal para delitos de tráfico de mínima escala de drogas. Las principales interrogantes que surgen dentro del estudio se asocian: ¿Cuáles son los fundamentos doctrinarios que se pueden manejar respecto de los delitos de tráfico de drogas en mínima escala?; ¿Cuáles son los elementos que configuran un modelo de estrategia de defensa en litigación oral? El presente documento científico, se determina en un orden teórico descriptivo de carácter documental, puesto que en este proceso se ha llevado a cabo una indagación, estructuración, tratamiento de la información y un escrutinio de varios documentos electrónicos y bibliografía respecto de la litigación penal, con el fin de crear un modelo y materializarlo en la práctica, con el fin de alcanzar una eficiente defensa técnica en cuanto a los delitos de tráfico de drogas en mínima escala. En cuanto a los resultados, se determina que la teoría del caso, es el factor principal que determinará el éxito del juicio. Esto por cuanto, el proceso penal es uno de conocimiento, es decir, conforme van avanzando sus etapas, se obtienen vestigios, evidencias, elementos de convicción, y prueba que permitirán arribar a una verdad procesal. Esta última permite identificar las circunstancias del hecho punible, u objeto de investigación, la identidad de los autores, y demás aspectos propios de la investigación penal.

Palabras clave: Litigación penal, juicio oral, prueba, teoría del delito, modelo de litigación.
INDIAN ARCHITECTURE: SCENARIO AT THE DAWN OF INDEPENDENCE
Authors: Chhabra Pankaj
Published: March 2023

At the time of Independence of India, the challenge was to create an image of a progressive nation through the mode of architectural expression to celebrate nation’s independence. Though it couldn’t happen right away as the majority of Indian architects at the time of independence were under the influence of architecture of the Britishers or were working in the architectural firms established by British architects. So, the change was gradual with its inception in pre- independence era of 1930s and 1940s, when some of the foreign architects designed and executed their projects with European expressionism and Bauhaus thinking in the country. But these were isolated efforts and could not take the shape of an architectural movement. These waves of rationalist thoughts kept on smoldering with war between the Revivalist and the Rationalists thoughts propagators throughout 1940s as well as at the time of independence and immediately after it. The journey progressed further with the arrival of foreign trained Indian architects. They brought with them ideas of modernism and thinking of Bauhaus rationalism. This movement further got expedited when the political patronage threw its weight behind rationalist thoughts over the Revivalist by inviting international Master of Modern Architecture to design on the Indian soil. Thus, this study is an effort to throw the light on the journey of Indian architecture from Swadeshi movement of 1930’s to Rationalist Modern architecture immediately after independence.
Production and Purification of Laccase enzyme by Trichoderma viride
Authors: Mohsen Liqaa Y. , Lilo Rafal Ahmed , Alwan Zeena Hadi Obaid , Al-Mamoori Ayad M.J
Published: March 2023

The ability of Trichoderma viride to synthesize extracellular enzymes (Lacase enzyme) using a substrate that contains media was examined. This isolate generated laccase at its greatest level (0.166U/ml) in liquid medium.  This study was  demonstrated the production, purification, and characterisation of the laccase enzyme from T.viride. The results showed that 96 hours was the optimum period of time for Laccase to incubate from this fungus. Laccase displayed the maximum level of activity at pH 4.5 and temperature 30 °C. The results revealed that the best ratio for laccase precipitation was 90%  by using ammonium sulphate.  In addition, for the purification of laccase enzyme, one peak of Laccase was appeared  in gel filtration purified from T.viride, while 2 peaks of Laccase were seen in ion exchange chromatography. According to the findings, the molecular weight of T. viride Laccase using SDS-PAGE was roughly 66KD under denaturation conditions.
Pancasila Karakter Khas Bangsa Indonesia
Authors: Yuliatin Yuliatin
Published: March 2023

Realitas kehidupan bangsa Indoenesia menujukkan adanya degradasi nilai-nilai Pancasila sebagai karaktaer bangsa Indonesia. Kondisi ini tentunya sangat penting diperhatikan guna membangun kesadaran bangsa Indonesia akan jati diri/karakter khas bangsa Indoenesia yaitu Pancasila. Berkenaan dengan hal itu, penulis sudah melakukan penelitian yang tujuannya adalah: (1) mendeskripsikan hakikat Pancasila bagi bangsa Indonesia, (2) mendeskripsikan nilai karakter dalam sila Pancasila. Penelitian yang sudah dilakukan menggunakan metode kualitaif yang dilakukan melalui studi Pustaka. Data dalam penelitian ini diperoleh melalui sumber yakni jurnal, buku dan situs internet yang tentunya memuat substansi yang relevan dengan fokus penelitian. Data dikumpulkan menggunakan teknik dokumentasi. Instrumen yang digunakan untuk mengumpulkan data berupa daftar check-list    klasifikasi bahan penelitian, format catatan yang digunakan dalam penelitian dan peta/skema penulisan. Data selanjutnya dianalisis menggunakan teknik Content Analysis (analisis isi). Hasil penelitian menujukkan bahwa: (1) hakikat Pancasila bagi bangsa Indonesia adalah sebagi karakter khas bagi seluruh bangsa Indonesia. Hal ini dikarenakan, dalam sila Pancasila terdapat nilai-nilai karakter luhur yang dipraktikkan oleh nenek moyang bangsa Indonesia yang kemudian menjadi cita-cita/tujuan/harapan untuk dapat diwujudkan menjadi karakter bagi seluruh masyarakat Indonesia, baik untuk masa sekarang, maupun di masa mendatang, (2) Dalam seluruh sila Pancasila, terkandung nilai karakter yang menjadi kekhasan bagi bangsa Indonesia. Dalam sila pertama Pancasila memuat nilai religius dan juga nilai toleransi dalam keberagaman agama. Dalam sila kedua Pancasila, terkandung nilai karakter sebagai perwujudan sifat adil dan beradab dalam seluruh dimensi kehidupan manusia. Dalam sila ketiga Pancasila, terkandung nilai karakter yaitu nasionalisme dan kecintaan pada tanah air. Dalam sila keempat Pancasila, memuat nilai karakter yaitu demokratis. Dalam sila kelima Pancasila, memuat nilai karakter, yaitu  peduli sosial.
A ARTE DO CIRCO COMO MEDIADORA NA CONSTITUIÇÃO DO SUJEITO E NA AMPLIAÇÃO DE SUAS POSSIBILIDADES
Authors:   , Silva Daniel vieira da
Published: March 2023

Esta pesquisa teve o objetivo de refletir acerca da temática que envolve a arte, formação e experiências artísticas no contexto circense. A problemática de estudo baseou-se no questionamento de como a arte pode ser um potente instrumento de mediação na constituição do sujeito. A metodologia utilizada foi a pesquisa bibliográfica em obras que valorizam, tanto os teóricos clássicos, como os recentes, além da pesquisa de campo que intencionou valorizar as construções subjetivas que norteiam esse processo. Para a realização da pesquisa de campo, contatamos quatro sujeitos que vivenciaram processos formativos em uma escola de circo e que atualmente se definem como artistas, arte-educadores e professores da área circense. Por meio de entrevistas alcançamos informações a respeito de como esses sujeitos vivenciam seus processos estéticos e como o contexto de ensino da arte circense foi concebido como um ampliador nas possibilidades profissionais e artísticas.
Coleção Livro Didático Digital (CLDD) - Natação
Authors: Pinto Ricardo Figueiredo
Published: March 2023

Aspectos históricos e a evolução da natação: origem, desenvolvimento,
institucionalização, mercantilização e análise básica das regras; Estudo da dimensão
social da natação; Aspectos técnicos: introdução aos movimentos técnicos, fundamentos
básicos e noções de salvamento; Reflexões sobre pesquisas e práticas de ensino da
natação
Estudos Avançados Interdisciplinares
Authors: Bassani Thais Regina , Santos Fernando Sluchensci dos , Dariva Helena Maria de Souza , Cunha Kelly Cristina Bicudo de Souza da , Guimarães Lilian Lemos da Silva , Soares Raquel Venero , Jankowitsch Jhonata , Bordalo Tayana de Souza , Santos Fábio José Brito dos , Corrêa Helano de Jesus , Santana Joalice Ribeiro , Vieira Poliana Sabóia , Fernandes Renata Moraes , Bugarim Jonatha Pereira , Andrade Giovana Frazon de , Barbosa Adriane Terezinha , Morgado Maria Fernanda Silva , Barbosa Maria Emília Marcondes , Vieira Maria Cristina Umpierrez , Neris Ayla de Assunção , Sousa Moisés Hamssés Sales de , Dias Edinete Neris , Aguiar Edinalva , Gonçalves Antonio Walberto Oliveira , Martins Brunna Lavôr , Barroso Ester Laignier , Martins Naytalla Nancy de Sousa , Almeida Ana Valéria Santos Pereira de , Sá Luma Thauany Lopes de , Veloso Christiane Carvalho , Agustinho Ana Gláucia Sousa , Veras Salvina Lopes Lima , Sousa Joélcio Braga de , Gonçalves Antonio Walberto Oliveira , Damasceno João Victor Santos , Oliveira Junior Alfredo Borges de , Silva Deborah Bezerra Lopes da , Eulálio João Pedro Liborio Neiva , Santos Neto João Pinheiro dos , Lucena Brenda de Jesus Moraes , Agustinho Ana Gláucia Sousa , Mendes Naiane Nascimento , Torres Elineuza Lopes , Veloso Christiane Carvalho , Branco Carlos Magno Araújo Castelo , Amaral Aluydio Bessa
Published: March 2023

É com muita satisfação que apresentamos o décimo sétimo volume da Coleção intitulada “ESTUDOS AVANÇADOS INTERDISCIPLINARES”, que reúne em seus capítulos pesquisadores de diversas instituições com discussões e temáticas que circundam uma gama de possibilidades de pesquisas e de relações dialógicas que certamente podem ser relevantes para o desenvolvimento social brasileiro a partir de uma ótica que contempla as mais vastas questões da sociedade. Tal obra visa dar publicidade a estudos e pesquisas frutos de árduos trabalhos acadêmicos que decerto contribuem, cada um a seu modo, para o aprofundamento de discussões em suas respectivas áreas pois são pesquisas germinadas, frutificadas e colhidas de temas atuais que estão sendo debatidos nas principais universidades nacionais e que refletem o interesse de pesquisadores no desenvolvimento social e científico que possam impactar positivamente a qualidade de vida de homens e de mulheres.
Legado Científico Brasileiro - Volume 10
Authors: Mochel Filho William de Jesus Ericeira
Published: March 2023

A coletânea Legado Científico Brasileiro é um marco nas publicações da Editora Pascal, trazendo artigos científicos de pesquisadores de todo o território nacional, em uma linguagem simples, objetiva, sem perder o rigor exigido pela ciência. Nessa obra marcante para a ciência brasileira, apresentamos uma publicação contendo estudos realizados por grupos de pesquisa de diferentes regiões do Brasil, que atuam em farmácia, educação, educação ambiental, medicina trazendo uma vasta gama de informações.
PRÁTICA DE VERMICOMPOSTAGEM COMO INSTRUMENTO DE EDUCAÇÃO AMBIENTAL PARA ALUNOS DO ENSINO FUNDAMENTAL NO MUNICÍPIO DE MOSTARDAS/RS
Authors: Costa Maiara Moraes , Souza Eduarda Gomes de , Souza Karine Fonseca de , Oliveira Liciane Rosa , Vargas Aline Braga , Fick Rubiane Buchweitz , Leandro Diuliana , Leon Ottoni Marques Moura de , Corrêa Érico Kunde , Corrêa Luciara Bilhalva
Published: March 2023

A maior parte dos resíduos sólidos gerados no Brasil consistem em fração orgânica e podem causar impactos ambientais negativos quando dispostos de maneira inadequada. Uma alternativa para o tratamento desses resíduos é a técnica de vermicompostagem, que compreende a reciclagem da matéria orgânica por minhocas, através da transformação biológica dos resíduos em adubo orgânico, que pode ser aplicado em plantas e quintais. Evidenciando a carência do conhecimento deste processo, a educação ambiental no ambiente escolar atua como disseminador dessa informação. Diante disso, o objetivo deste trabalho consiste no desenvolvimento de atividades de educação ambiental para alunos do ensino fundamental através da apresentação da prática de vermicompostagem como forma de tratamento dos resíduos sólidos orgânicos. O andamento da atividade deu-se em uma escola de ensino fundamental, na cidade de Mostardas-RS. O presente estudo classifica-se como uma pesquisa de caráter qualitativo e foi desenvolvido em três fases, por meio da execução de uma palestra, uma oficina educativa sobre vermicompostagem e a realização de jogo interativo de cartas. A realização das atividades possibilitou a disseminação de conhecimento sobre a forma que ocorre a prática de vermicompostagem, através da desmonstração de como ocorre a prática e da interação dos alunos nos jogos de cartas. Em síntese, verificou-se que os alunos ficaram instigados com a possibilidade de realizar a prática de vermicompostagem nos domicílios para a diminuição do envio de resíduos sólidos para aterros sanitários, atuando como pequenos intermediários do desenvolvimento sustentável na sociedade.

Palavras-chave: Resíduos Sólidos Orgânicos, Escola, Educação Ambiental.
SÍNDROME INFLAMATÓRIA MULTISSISTÊMICA PEDIÁTRICA ASSOCIADA À COVID-19: ASPECTOS GERAIS
Authors: Câmara Ângela Maria Araújo , Campos Ynaiara Jane de Morais Moreira , Soares Michele Costa , Lima Renata de Araújo , Santos João Paulo da Silva , Costa Danielle Jesus Araújo da , Freire Tatiane Timóteo , Firmo Wellyson da Cunha Araújo
Published: March 2023

A pandemia originada pelo vírus SARS-COV-2, causador da doença COVID–19 obteve uma proporção grandiosa, afetando milhares de pessoas. Dentre os acometidos, as crianças configuram parte da população com o menor número de casos confirmados, além também, de expressarem formas mais brandas da doença. Contudo, pacientes pediátricos positivados com SARS-COV-2 vem apresentando uma evolução grave para o quadro de Síndrome Inflamatória Multissistêmica Pediátrica (SIM-P) aumentando a probabilidade de mortalidade numa parcela da população que antes não era tão afligida. Diante disso, o presente trabalho objetivou fazer um levantamento sobre SIM-P quanto aos aspectos gerais da manifestação da doença. Para tal, elaborou um estudo bibliográfico descritivo com base nos trabalhos publicados durante os anos de 2020 a 2022. Foi observado que há uma semelhança muito grande da SIM-P associada à COVID-19 com a doença de Kawasaki, onde ambas compartilham de características laboratoriais e clínicas, como a febre alta prolongada e disfunção multiorgânica. Outro ponto de suma importância são as complicações desenvolvidas a partir das disfunções cardíacas, como a miocardite. O diagnóstico no Brasil é dado com base no protocolo disponibilizado pela Organização Mundial de Saúde e a terapêutica aplicada dependerá do quadro clínico e sua gravidade expressa pelo paciente. Com isso, por mais que as crianças sejam menos contaminadas pela COVID-19 e possuam menores chances de desenvolver complicações e evoluírem a óbito o cuidado para com elas deve ser mantido colocando em prática medidas preventivas, em especial, a vacinação quando possível.

Palavras-chave: COVID-19; Pediatria; Inflamação; Multissistêmica.
Effects of Pleiotrophin (PTN) on the resistance to paclitaxel in ovarian cancer cells
Authors: Yunfei Li , Huali Liu , Linlin Ding , Liwei You , Yuqiang Zhang , Xingxing Wang , Xueyuan Lin , Liquan Yang
Published: March 2023

The pathogenesis of an ovarian disease is connected with PTN and its receptor protein tyrosine phosphatase receptor Z1 (PTPRZ1). Paclitaxel is the first-line drug for the therapy of ovarian cancer. With the increment of paclitaxel chemotherapy, paclitaxel obstruction happens in the late phase of therapy frequently. By treating A2780 and SKOV-3 cells with PTN, we found the development of the two cell lines was enhanced. Different concentrations of PTN were added to A2780 and SKOV-3 cells treated with paclitaxel and the results of MTT showed that the inhibitory effect of paclitaxel on these two cell lines was weakened. The results of apoptosis assays showed that PTN could slow down the rate of apoptosis and its concentration dependence in both cell lines. To further investigate the impact of PTN on the paclitaxel responsiveness of ovarian malignant growth cells, A2780 and SKOV-3 cells were transfected with sh-PTN-1, sh-PTN-2 and sh-NC plasmids. The results of PCR and Western Blot showed that both RNA-interfering plasmids could inhibit PTN in A2780 and SKOV-3 cells. The results of MTT showed that the inhibitory effect of paclitaxel on cells transfected with sh-PTN-1 expanded compared with the benchmark group. Apoptosis assays showed that the complete apoptosis pace of A2780 and SKOV-3 cells with sh-PTN-1 plasmid induced by paclitaxel was accelerated obviously compared with the benchmark group. To summarize, the results suggested that PTN could enhance the resistance to paclitaxel in ovarian cancer cells, which provides a groundwork for studying on drug resistance of cancer cells to paclitaxel and a new perspective for ovarian cancer therapy.
Antiproliferative Activity of Spironolactone: In Vitro Study
Authors: Taher Mohammed A.
Published: March 2023

Spironolactone SPL stock solution was studied against two cancer cell lines Hep-2, and AMN-3. These cell lines were exposed to different concentrations of SPL ranged from 0.0019 to 1000 µg/ml for 24, 48 and 72 hours durations. The optical density was measured under wavelength 492 nm with micro-ELISA reader after their staining with crystal violet dye. The results revealed a clear cytotoxic activity of pure SPL with high significances in a two cancer cell lines during the three exposure time, suggesting that the cytotoxic effect of pure spironolactone is a dose and time dependant. The best cytotoxic activity was on AMN-3 and Hep-2 cell lines at the high concentrations 1000, 500, 250, 125µg/ml. The results also suggest that AMN-3 cell line is the most sensitive cancer cell line to pure SPL than Hep-2 cell line after 24 hr. of exposure to drug
Oxidative Stress and Erythrocyte Glutathione Defense System in Smokers and Non-smokers Gastric Carcinoma Patients
Authors: Jasim Basma T.
Published: March 2023

The oxidative stress and the status of erythrocyte glutathione defense system were studied in male patients with gastric carcinoma in order to elucidate their clinical importance in the diagnosis. The study included 60 male patients with gastric cancer (30 non-smokers and 30 smokers) and an equal number of age-matched healthy control subjects. The incidence of oxidative stress was determined by measurement of the oxidative stress marker-malondialdehyde (MDA) in the plasma. The status of glutathione defense system was determined by measuring the level of reduced glutathione, as well as the activity of the enzymes: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST) in the erythrocytes. After data analysis the following observations were obtained: plasma MDA level was significantly higher in smokers than non-smokers gastric cancer patients. The activities of erythrocyte SOD, CAT, GSH-Px, GST and reduced GSH levels were decreased in gastric cancer patients who were smokers as compared to non-smokers gastric cancer patients. In conclusion, smokers with gastric carcinoma are at high risk of oxidative stress, which in turn may result in initiating the promotion phase of carcinogenesis and generation of more cancerous cells. Moreover; plasma MDA and erythrocyte glutathione defense system may serve as a good auxiliary biochemical index in the diagnosis of patients with gastric carcinoma
Data Analytics of an Information System Based on a Markov Decision Process and a Partially Observable Markov Decision Process
Authors: Wang Lidong , Mosher Reed L. , Falls Terril C. , Duett Patti
Published: March 2023

Data analytics of an information system is conducted based on a Markov decision process (MDP) and a partially observable Markov decision process (POMDP) in this paper. Data analytics over a finite planning horizon and an infinite planning horizon for a discounted MDP is performed, respectively. Value iteration (VI), policy iteration (PI), and Q-learning are utilized in the data analytics for a discounted MDP over an infinite planning horizon to evaluate the validity of the MDP model. The optimal policy to minimize the total expected cost of states of the information system is obtained based on the MDP. In the analytics for a discounted POMDP over an infinite planning horizon of the information system, the effects of various parameters on the total expected cost of the information system are studied.
Non-communicable disease multimorbidity: Challenges and solutions
Authors: Georges Rachid Hatem  , Melissa Ghassan Hatem
Published: March 2023

The fast-developing multimorbidity is often a negative prognostic factor for disability, particularly among older populations, and is associated with intellectual, psychological, and social adverse outcomes. Practices must target patients with complex multimorbidity and adopt the principle of continuity of care through routine extended consultations allowing protected time to manage problems encountered in chronic diseases. This brief communication presents some challenges and solutions for non-communicable disease multimorbidity. Accordingly, research funders must call for multimorbidity-focused investigations to mitigate the impact of multimorbidity on patients.
A review on Angelman syndrome
Authors: Swathi Krishna KV  , Vasunoori Anitha  , Vasunoori Hemalatha  , Vinukonda Aravindh  , Yalakapalli Poojasree  , Yarraballi Suneel kumar
Published: March 2023

"Angelman syndrome" AS seems to be a neurodevelopmental illness for whom significant aspects were learning impairment, total absence like presentation, convulsions, and a character trait behavior resume. Its behavior includes the delighted public persona, easily angered amusement, hard time concentrating, and hyper motoric actions, swearing like things, disruptive behavior, and an attachment such as liquid. Developmental problems and delicate dysphoric includes, along with incoordination and other mobility disruptions, have been extra functionality in essential people with the condition. And so is resulting from short invocation of something like the tubulin nutrient ubiquitin E3A (ube3a) mutation, which shows parental bonding. There are four single-molecule classrooms upon as, and somegenotype–phenotype collinearity has popped up. More than stays to be acknowledged about why issues like E6-AP and its nutrient merchandise like UBE3A end up in its noticed neurobehavioral deficit spending. Research like animal studies has allegedly involved UBE3A along with experience-dependent synapses redeveloping. Its pharmacogenetic facets include Angelman disorder, its basic biomolecular tenets, and access to basic service methods. And so is one neurobehavioral disorder that is characterized while also a severely impaired handicap, engine failure to thrive, communication difficulties, impulsiveness, but also ordinary epileptic fits. And so is attributable to interruption of prenatally conveyed but also generationally ingrained UBE3A, which also lossless encoding the ubiquitin secondments. Four methods in the production of its gene encoding UBE3A non - functional were also acknowledged, the most typical of which would be the deactivation of such motherly love human chromosome 15q11-q13. Amazingly, redundancy with the same human chromosome is amongst the few best-described continual chromosomal mutations linked to asperger's syndrome disease, cropping up along >1–2 Percentage among all situations like autism diagnosis. While outcome morphological characteristics of something like the central nervous system and communication like neurons projected numbers are mainly standard in animal studies, primary operating deficiencies were also discovered just at a standard like discussion training. Also, they impeded developmental processes like learning, memory, and neurogenesis circuit design. Offers similar promote confidence a significant involvement such as proteolysis protein ligase E3A along synapses advancement, its operations to dysfunction like tubulin transcription factor E3A results samples pathogenic mechanisms along living beings poor job performance did understand. but even so, current attempts have also shown keep promising through trying to restore continues to function interrupted into it as mouse model, reactivating keep hoping how the effectiveness of treatment's management strategic plan could be discovered.
Hypogonadism and erectile dysfunction in patients with chronic kidney disease undergoing hemodialysis
Authors: Gabriela Carvalho Maciel  , Leonardo Antunes Oliveira  , Victor Augusto Dias Chaves  , Otávio Cabral Coelho  , Vitor Gibran Lemes Nunes  , Eder Roberto Antoniello Capuzi  , Luiz Carlos Maciel
Published: March 2023

Objective: To know the profile of Hypogonadism and Erectile Dysfunction (ED) in patients with chronic kidney disease (CKD) on hemodialysis studied. Method: The case-control study was the Case group, consisting of patients with CKD on hemodialysis (INEFRO) and the Control group by patients under outpatient follow-up. The Androgenic Deficiency in Aging Males (ADAM) and International Index of Erectile Function (IIEF) questionnaires were applied, and the following clinical examinations were performed: orchidometry, analysis of hair distribution, gynecomastia and BMI. Results: ADAM’s mean score was 4.2 points (case) and 1.9 points (control). In the Case group 60% have observed decreased libido and 70% perceived that the erections are less vigorous. In the Control group, prevalence decreased to 30% in both questions. In the analysis of IIEF-5, the mean score was 16.63 (case) and 19.93 (control). 60% of patients in the Case group and 50% of the Control group have some degree of ED. Gynecomastia was evaluated in 20% (case) and 7% (control). The orchidometry of the Case group revealed prevalence in 53.33% of testicular volume 3 patients of the orchidometer. In the control group, the most prevalent measure was 4, found in half of the patients (50%). Conclusions: Through the questionnaires applied in both groups with similar mean ages, it can be inferred that patients in the Case group experienced earlier, throughout the dialysis process, a direct impact on sexual quality, with decreased libido and difficulty in the reaction when compared to the Control group.
Forecasting value of production of palay and retail price of rice in the Philippines using ARIMA modelling
Authors: Kevin-Caldemon-Handa  , Michelle-Malapit-Mila  , Aubrey Jane-Atilano-Sabalberino
Published: March 2023

As rice (milled palay) is an integral part of a Filipino meal, it is important to have an accurate estimation of its governing economic factors such as value of production and retail price. This study utilized Autoregressive Integrated Moving Average (ARIMA) Modelling and Box-Jenkins Method to forecast the value of production of palay and the retail price of the three varieties of its end-product, rice (regular-milled, well-milled, and special), for 2023 to 2027 using historical data from 2000 to 2022, and from 2012 to 2021, respectively. Results suggested that ARIMA (4, 1, 1) can be used to predict the value of production of palay, and ARIMA (1, 1, 1) to predict the retail prices of the three rice varieties. The value of production of palay was forecasted to continuously increase for the next 5 years, retaining its annual seasonal behavior. The retail price of all the three rice varieties were also forecasted to continuously increase, with the special variety of rice expected to surpass its 2018 maximum value by 2027. This study will be of significance in ensuring adequacy and stability of supply in the country for this major agricultural crop.
Authors: Abriyah Abriyah , Rini Candra Puspita , Zuliani Rizki , Hartantri Saktian Dwi , Amaliyah Aam
Published: March 2023

This study aims to determine the significant differences in the ability to think inductive science between students who are given CLIS (Children Learning In Science) learning models with students who are given conventional learning. The sample studied consisted of 30 experimental class students and 30 control class students. before it is given to the research object, the instrument test is done first, namely the validity and reliability test with 20 valid essay questions.  Before the data analysis required normality test with Chi Square test (2) obtained 2 count = 38.41> 2 tables = 7.815 and control class 2 count = 39.55 <2 tables = 7.815, then H0 was accepted by normal samples.  As well as Homogeneity test with pretest data Fcount = 2.128> Ftabel 1.850 and posttest data Fcount 0.875> Ftabel 1.850 it is a t-test with a significance level α = 0.05.  For pretest data tcount = 2.049  ttable = 2.045.  Then H0 is rejected H0 is accepted. It can be concluded from the results of hypothesis testing that there are significant differences in the application of the CLIS (Children Learning In Science) learning model to the Students' Inductive Thinking Ability in Science Learning for Class V Students of SD Pakuhaji II Elementary School Pakuhaji District Tangerang
Authors: Baharudin Muhammad Bayu , Subayani Nataria Wahyuning , Nugraha Arya Setya
Published: March 2023

Motivasi belajar merupakan sesuatu yang dapat merubah perilaku peserta didik untuk menjadi lebih baik dengan tujuan memperoleh hasil belajar yang maksimal. Motivasi sangat diperlukan dalam kegiatan belajar yang sedang berlangsung, karena motivasi berperan sebagai daya penggerak di dalam diri yang mendukung kegiatan pembelajaran. Motivasi belajar dapat dikatakan sebagai suatu dorongan yang membuat seseorang melakukan tindakan tertentu guna mencapai suatu tujuan, baik secara internal atau eksternal dengan harapan memperoleh ketuntasan hasil belajar yang mana hasil belajar yang diperoleh diatas kkm. Akan tetapi masih ada peserta didik yang motivasi belajarnya rendah. Pengaturan desain kelas model “U” adalah semua peserta didik dapat berhadapan langsung dan berinteraksi secara langsung dengan guru, sehingga akan lebih fokus saat pembelajaran berlangsung. Jenis penelitian yang penulis gunakan adalah pendekatan kualitatif dengan menggunakan analisis deskriptif melalui penelitian lapangan yang bertujuan untuk mendeskripsikan bagaimana pengaruh desain kelas model U terhadap motivasi belajar matematika pada materi luas persegi. Teknik pada penellitian ini menggunakan teknik pengumpulan data berupa observasi, wawancara dan dokumentasi sedangkan analisis data pada penelitian ini yaitu reduksi data,penyajian data dan penarikan kesimpulan. Hasil penelitian ini menunjukkan bahwa pengaruh desain kelas model U sangat berpengaruh terhadap motivasi belajar peserta didik. Hal tersebut dapat dilihat pada aktivitas peserta didik, yang mana dalam penelitian ini sebagian sudah dapat mengikuti dengan baik. Aktivitas guru pada saat penelitian masih belom bisa mengkondisikan peserta didik dengan tertib dan tidak rami namun guru sudah bisa menerapkan desain kelas model U dalam pembelajaran. Kesulitan yang dialami peserta didik pada umumnya lupa dengan materi tersebut ataupun belom paham dan masih ada peserta didik sulit fokus ketika pembelajaran berlangsung.
Contrasting Tanzanian and Italian Perspectives on Motherhood and Mothering
Authors: Mabilia Mara
Published: March 2023

This report reflects on, and contrasts, gender in Italy and among the Wagogo of Tanzania with regard to two distinct concepts: motherhood and mothering. In  both realities women are under scrutiny: particularly, their bodies are seen as the vessels of their reproductive capacity and the locus of their sexual activity. Among the Wagogo as well as in Italy women’s sexuality and reproductive potential are subjected to social control which seems to ignore a fundamental consideration—and its implications: a woman is first of all a person.

 

Keywords: Italy, maternity, motherhood, mothering, Wagogo
Kinship, Migrations and the State
Authors: Fonseca Claudia , Jardim Denise
Published: March 2023

Anthropologists have long studied ‘exotic’ kinship patterns in distant places that differedfrom what was seen as the traditional nuclear family. The second half of the twentiethcentury witnessed a number of changes (new patterns of birth and marriage, new reproductive technologies, the increased visibility of step- and adoptive  elations) that changed scholars’ perceptions, convincing them that the traditional—even in Europe and North America—was no longer a helpful concept in  understanding contemporary family dynamics. Accordingly, anthropologists reformulated their analytical tools to take stock of the variety of contemporary understandings of family life, placing the emphasis not on sexual procreation and blood connections, but on an enduring sentiment of diffuse solidarity: relatedness (Carsten 2000).
A Study on the Second Frame in Film  -Focusing on Iconology by Panofsky
Authors:   Korean Institute of Smart Media, Jia Xunyue
Published: March 2023

As one of the image symbols, the second frame has rich symbolic metaphor. In previous studies, second frames are mostly presented in physical forms such as doors, windows, but in , there are various forms of second frames, providing more types for the study of second frames. Panofsky's Iconology has put forward a rigorous research method on how to interpret the meaning of image symbols in the picture. This study aims to use Panofsky's Iconology to analyze the second frame in . The purpose is to expand the methodology of film image research and break through the problem that the Iconology analysis of film image stays in narrative analysis (iconographical analysis). It can be seen from the results of this study that the second frame has different visual presentation according to the requirements of narrative. In the narrative of the film, it symbolizes the depressed tone of the film and the stressful relationship between different characters. What director Campion wants to show through the second frame is that in the film industry where the problem of women is getting better, the motif of feminist film creation has changed from the expression of female appeals in binary opposition to the expression of the appeals of diverse groups in “decentralization.”
The Impact of Dharar [Damage], Maslahat [Benefits] and Religiosity to Smoking Behaviour
Authors: Marpaung Watni
Published: March 2023

There is still much debate about smoking behavior in Indonesia, some scholars declare it haram [forbidden] to smoke, but others state it is forbidden. There is still a lot of debate among Muslims regarding the maslahat [benefits] and dharar [damage] resulting from smoking. Researchers want to see the effect of maslahat, dharar [damage], and Religiosity on the smoking law. This study followed a cross-sectional design conducted by interviewing 518 Muslim youths taken using the snowball method and disseminating online questionnaires; data analysis uses SMART PLS with a CI of 95%. The results of this study showed an effect between maslahat [benefits] (p<0.001 and T=4.010), dhara (p=0.006 and T=2.744) to fatwa perspective [the view of a group of ulemas about a problem in perspective in Islamic law] and no significance between Religiosity (p=0.433 and T=0.785) to fatwa perspective. There is a significant influence between maslahat [benefits] (p<0.001 and T=4.605), dharar [damage] (p=0.0027 and T=2.218), and Religiosity (p=0.001 and T=2.596) on smoking law. The Indonesian government must be intense in socializing the maslahat [benefits] of smoking behavior and explaining that there is no benefit, so Muslim youths should consider smoking. This is by the rules of Ushul Fiqh, “the government policy is meant to maslahat [benefits] ” through the fatwa on smoking haram [forbidden] for Muslims issued by the Indonesian Ulema Council (MUI) and Muhammadiyah [Muhammadiyah is one of the islamic organization].
Religious Education, Smoking Laws and Islamic Organisations with Mosque Worshipers Smoking Behaviour
Authors: Marpaung Watni
Published: March 2023

There are differences in fatwas about smoking by Islamic organizations, which will impact worshipers' smoking behavior. Behaviors like smoking will be linked to internal factors like being part of an Islamic group, getting religious education, and knowing about the smoking law. Smoking is an activity carried out by many people in Indonesia. Even though smoking is dangerous to health, it is triggering non-communicable diseases, which cause an increase in disability and death. This study follows a cross-sectional design by interviewing 530 Muslims who have prayed in the mosque for the last 14 days. This study used a pre-prepared closed questionnaire. Frequency distribution and cross-tabulation were carried out using JAPS 16 software. The results of this study show that people with religious education are less likely to smoke (12.1% at boarding schools and 36.7% at madrasah aliyah). Mosque worshipers who think smoking has a haram law tend never to smoke (34.1%), while among those who view smoking as a makruh law, many still smoke (4%). The results of this study indicate that Muhammadiyah organizations tend never to smoke (5.8%), Salafi organizations tend not to smoke (1.7%), and Nahdatul Ulama organizations tend not to smoke (80.8%). Many members of the Nahdatul Ulama organization still smoke cigarettes (5.5%). There is a strong link between smoking and things that happen on the inside, like religious education, smoking laws, and Islamic groups. Islamic organizations and smoking laws are factors that have an impact on the smoking behavior of mosque congregations.

 