bluuebunny/crossref_metadata_2025 huggingface dataset:
The Antiaging Potential of Serum Formulations from Centella asiatica, Curcuma longa, Aloe vera, Rosa centifolia, and Salmon DNA on Injured Human Fibroblast Cells
Authors: Girsang Ermi , Wargasetia Teresa Liliana , Rahmat Deni , Gondokesumo Marisca Evalina , Harjanti Mathelda Weni , Widowati Wahyu , Zahiroh Fadhilah Haifa , Saufa Zahra Qisthi , Takasenserang Oktaviana , Hadiprasetyo Dhanar Septyawan
Published: February 2025

External aging factors such as UV exposure, pollution, and lifestyle choices contribute to skin aging, resulting in deep wrinkles, fine lines, and rough skin, which can lower self-confidence. Plant extracts have been widely studied for their antiaging potential, while Salmon DNA has shown promise in stimulating collagen production. This study explores the formulation of a serum combining Centella asiatica, Curcuma longa, Aloe vera, Rosa centifolia, and Salmon DNA for its antiaging effects on injured human fibroblast cells. The serum was formulated using extracts from C. asiatica, C. longa, A. vera, R. centifolia, and Salmon DNA. Antioxidant activity was evaluated with the DPPH method, cytotoxicity using the WST-8 assay, and gene expression through qRT-PCR for COL1A1, TGF-β1, HYAL-1, and FGF-2. The serum exhibited weak antioxidant activity (IC50 = 373.33 µg/ml) and reduced cell viability at high concentrations. Gene expression analysis revealed increased expression of COL1A1, TGF-β1, and FGF-2, along with reduced HYAL-1 expression in injured BJ cells. The formulated serum shows potential as an antiaging agent, promoting collagen production and reducing hyaluronidase activity.
The pipB Gene as Target for Development of Detection Method of Pathogenic Bacteria Salmonella typhi Using Real-time Polymerase Chain Reaction
Authors: Nurjayadi Muktiningsih , Gusti Angieta Putri  , Ananda Indah Putri Sihombing  , Puan Aqila Azizah  , Anisa Fitriyanti  , Royna Rahma Musie  , Helzi Angelina  , Grace  , Agus Setiawan  , Dandy Akbar Juliansyah  , Jefferson Lynford Declan  , Gladys Indira Putri  , Siti Fatimah  , Adinda Myra Amalia Putri  , Vira Saamia  , Irma Ratna Kartika  , Fera Kurniadewi  , Shyi-Tien Chen  , Bassam Abomoelak  , Hesham A. El Enshasy
Published: February 2025

Salmonella typhi is a bacteria that leads to typhoid fever and one of the causes of death due to bacteria infections. In Indonesia, typhoid fever occurs around 1,100 cases per 100,000 population per year, with a mortality rate of 3.1-10.4%. It's necessary to develop a rapid and accurate detection of Salmonella typhi. The pipB gene of Salmonella typhi has the function of being an autophagia inhibitor in humans. This study aims to develop a detection kit for Salmonella typhi pathogenic bacteria targeting the pipB gene using a pipB primer in confirmation, specificity, and sensitivity tests. The results showed that pipB primer can amplify Salmonella typhi DNA fragment of 196 bp at the optimum annealing temperatures between 54-62°C. Confirmation test with real-time PCR found that the pipB primer pair (pipB-F and pipB-R) amplified at cycle 12.93 and 13.10 (Duplo) with a Tm value of 84.05°C and 84.20°C (Duplo). Based on the difference and average value produced in the confirmation and specificity test, pipB primer has amplified Salmonella typhi DNA at Ct 12.47±0.6 with a Tm value of 83.62°C±0.6. The pipB primer pair (pipB-F and pipB-R) could distinguish target from non-target bacteria based on their cycle threshold (Ct) and melting temperature (Tm) values. The primer design of pipB primer pair (pipB-F and pipB-R) successfully detected Salmonella typhi bacteria with the smallest concentration of 55.78 × 102 CFU equivalent to 3.2 pg/µL. Based on the results, Salmonella typhi pipB primer successfully detected Salmonella typhi bacteria DNA rapidly, specifically, and sensitively using the real-time polymerase chain reaction method.
The Influence of Green Logistics and Food Distribution Strategy on Post-Harvest Loss Reduction
Authors: Issah Ofori , Ackah David
Published: February 2025

Post-harvest losses are a significant issue confronting farmers in Ghana, which requires the proper intervention to help deal with the situation and improve the social and economic life of the farmers. The farms in Ghana are primarily located in the hinterlands, making it very difficult to get the agri-food stuff transported to the marketplaces or points of a process, usually leading to substantial post-harvest losses due to the short life of most of the foodstuff. Therefore, it is imperative to devise the right food distribution strategy to reduce post-harvest loss. The study examined the influence of green logistics and food distribution strategy on post-harvest loss reduction. Structural equation modelling was used to analyse 238 useable data from the extension officers, freight forwarding/logistics companies, and local food distributing agencies in Ghana. We found support for all the two hypotheses. We then offer both theoretical and managerial implications.
Supply Chain Collaboration, Organizational Resources and Firms’ Performance
Authors: Issah Ofori , Ackah David , Patricia Owusu-Asantewaah
Published: February 2025

This study primarily investigates the linkage between supply chain collaboration, organisational resources and firms’ performance. The study employs a quantitative research approach with cross-sectional survey data from 163 collected from logistics companies in the Graeter Accra Region of Ghana. The study analysed the data gathered using SPSS (version 22). The results show a positive and significant relationship between supply chain collaboration and supply chain performance. It was also further established that a positive and meaningful relationship exists between organisational resources and supply chain performance. This paper proposes and tests a hypothetical model that investigates the relationship between supply chain collaboration, organisational resources and supply chain performance.
Procurement Strategies and Competitive Advantage: Assessing the Impact of Project Performance as a Moderator
Authors: Ofori Issah , Agyei Baah Samuel , Appiah-Kubi Evelyn , Kwame Afriyie Henry
Published: February 2025

In the modern business landscape, procurement strategies have emerged as essential tools for achieving competitive advantage. As organizations face increasing pressure to deliver superior products and services while maintaining cost-efficiency, the adoption of effective procurement strategies becomes crucial for long-term success (Cousins et al., 2019). These strategies encompass various practices such as cost management, supplier relationship management, and sustainable sourcing, which collectively aim to improve operational efficiency, reduce costs, and drive innovation (Brammer & Walker, 2021). While research has extensively examined the direct impact of procurement strategies on organizational performance, less attention has been paid to understanding the role of project performance as a moderating factor in this relationship (Meng, 2020). Project performance, which refers to the successful execution of projects in terms of time, cost, and quality, is often overlooked in the context of procurement strategies. However, project performance is an essential determinant of whether procurement strategies achieve the desired competitive advantage (Muller et al., 2021). This study follows an explanatory research design, which is primarily aimed at understanding the cause-and-effect relationships among variables (Saunders et al., 2019). The explanatory approach explored how procurement practices affect competitive advantage, and how project performance moderates this relationship. This design is appropriate for testing hypotheses that seek to explain the impact of project performance as a moderator in this relationship. A quantitative approach was adopted, as it allows for the measurement of relationships and the testing of hypotheses using statistical techniques (Bryman & Bell, 2019). The quantitative approach is suitable for this study since it involves numerical data that can be analyzed to identify the strength and direction of relationships. Data was collected through primary sources using a structured questionnaire. The findings of the study statistically indicate that procurement strategies have a positive and significant influence on competitive advantage. Project performance has a positive and significant influence on competitive advantage.  Project performance positively and significantly moderates the relationship between   procurement strategies and competitive advantage. The study recommends that organizations should enhanced execution and efficiency, embrace adaptability and innovation, ensure strategic alignment and goal achievement, risk mitigation and, operational excellence.
Identification of echinocytes as a predictor of preeclampsia in patients at risk
Authors: Mulia Soto AS , Rodríguez Piñ MD , Escobar Alva CA , Rosas Ortega PA , Mendieta Zeron H
Published: February 2025

Objective: In Mexico, preeclampsia is the main cause of maternal death. The aim of this study was to determine whether the identification of echinocytes increases the prediction of preeclampsia in patients at risk.
Material and methods: In this prospective, descriptive, cross-sectional study, a peripheral blood smear from pregnant women with risk factors was taken and stained with an acid-base stain (Wright).
Results: The analysis was done on 41 patients (age 24 ± 6.8 years), weeks of gestation 33.4 ± 6. Echinocytes were present in six of seven women who developed preeclampsia (Relative risk: 3.84, 95% confidence interval = 0.508, 29.001).
Conclusion: The identification of morphological alterations of erythrocytes, and specifically of echinocytes, in a peripheral blood smear in pregnant patients, may indicate an imminent risk of developing preeclampsia.
Objectif: Au Mexique, la prééclampsie est la principale cause de mortalité maternelle. L'objectif de cette étude était de déterminer si l'identification des échinocytes augmente la prédiction de la prééclampsie chez les patientes à risque.
Matériel et méthodes: Dans cette étude prospective, descriptive et transversale, un frottis sanguin périphérique de femmes enceintes présentant des facteurs de risque a été prélevé et coloré avec une coloration acido-basique (Wright).
Résultats: L'analyse a été réalisée sur 41 patientes (âge 24 ± 6,8 ans), semaines de gestation 33,4 ± 6. Des échinocytes étaient présents chez six des sept femmes ayant développé une prééclampsie (risque relatif: 3,84, intervalle de confiance à 95 % = 0,508, 29,001).
Conclusion: L'identification d'altérations morphologiques des érythrocytes, et spécifiquement des échinocytes, dans un frottis sanguin périphérique chez des patientes enceintes, peut indiquer un risque imminent de développer une prééclampsie.
Morbidité et mortalité des nouveau-nés de faible poids de naissance dans l’unité de néonatologie du Centre Hospitalier Universitaire départemental de Parakou en 2020
Authors: Kpanidja MG , Noudamadjo A , Agbeille Mohamed F , Akohouhoue SI , Adedemy JD , Agossou J
Published: February 2025

Introduction : les nouveau-nés de Faible Poids de Naissance (FPN) constituent une préoccupation majeure dans les pays en développement. L’objectif de ce travail était d’étudier la morbidité et la mortalité des nouveau-nés de faibles poids de naissance dans l’unité de néonatologie du Centre Hospitalier Universitaire Départemental de Parakou. Population et méthodes : Il s’est agi d’une étude prospective allant du 1er août 2019 au 30 septembre 2020. Etaient inclus les nouveau-nés ayant un poids de naissance supérieur à 500g et inférieur à 2500g. Les variables étudiées étaient relatives aux données socio démographiques, les caractéristiques cliniques diagnostiques et évolutives. L’enregistrement des données recueillies a été fait par le logiciel Epi Data 3.1 version française. Les données ont été analysées par le logiciel Epi info version 7.2.2. et SPSS version 2.6. Résultats : Nous avons inclus 129 nouveau- nés au total. Les nouveau-nés de sexe masculin représentaient 43,41%. L’âge gestationnel moyen était de 32,39±2,72 SA et le poids de naissance moyen de 1520,08g ±331,19g à la naissance. L’âge moyen des mères était de 27,40 ans±06,75ans avec les extrêmes de 15 et 47ans. Les pathologies survenues au cours des grossesses étaient la menace d’accouchement prématuré (67,44%), et la pré-éclampsie (06,20%). La comorbidité était représentée par les infections néonatales (87,60%), la détresse respiratoire (55,81%) et l’hypothermie (32,56%). La mortalité était de 15,50% Conclusion : les défis restent à relever pour améliorer la prise en charge du FPN.
Introduction: low birth weight newborns constitute a major concen in developing countries. The objective of this work was to study the morbidity and mortality of low birth weight newborns in the neonatology unit of the Parakou departemental university hospital center. Population and method: This was a prospective study from August 1, 2019 to September 30, 2020. Newborns with a birth weight between 500 and 2500 were included. The variables studied were related to sociodemoghraphic, clinical, diagnostic, and progressive charasteristics. Results: We included a total of 129 newborns. Male newborns accounted for 43.41% . The average gestational age was 32.39 ± 2.72 WA and the average birth weight was 1520.08g ± 331.19g. Pathologies occurring during pregnacy were threat of premature birth (67.44), and pre-eclampsia (06.20%). Comorbidity was represented by neonatal infections 87.60, respiratory distress (55.81) and hypothermia (32.81). The mortality rate was 15.50%. Conclusion: challenges remain to improve the care of low birth weights.
Role of medical writing: From daily clinical practice to in peer-reviewed journals
Authors: Ferrari R , Amouzou KS
Published: February 2025

This brief communication aims to highlight the purposes and characteristics of medical writing for doctors by following a fil rouge from daily clinical practice to publications in peer-reviewed international journals. Interweaved in any medical activity, medical writing can help create professional networks. Additionally, medical writing establishes a platform for documenting expertise that can be shared to enhance healthcare in any setting.
Cette brève communication a pour but de mettre en lumière les objectifs et les caractéristiques de la rédaction scientifique médicale pour les professionnels du milieu médical en suivant un fil conducteur allant de la pratique quotidienne à la publication dans des journaux à comité de lecture. Inscrite dans toutes les activités médicales, la rédaction médicale peut aider à créer un réseau professionnel. De plus, la rédaction médicale établit une plateforme pour une documentation experte qui peut être partagée pour avancer les soins dans les structures sanitaires.
Traumatismes alvéolo-dentaires liés aux accidents de la voie publique : aspects épidémiologique, clinique et thérapeutique à l’hôpital régional de Mamou en république de Guinée
Authors: Condé M , Camara AA , Nabé AB , N’Diaye T , Doré M , Keïta T , Traoré N
Published: February 2025

Introduction : Les traumatismes dentaires sont considérés comme un problème de santé publique en raison de leur fréquence dans la société et de leurs impacts négatifs sur la qualité de vie. L’objectif de cette étude était de contribuer à l’étude des traumatismes alvéolo-dentaires liés aux accidents de la voie publique. Méthodes : Il s’agit d’une étude prospective de type descriptif allant de juillet à décembre 2019 portant sur 125 patients admis au cabinet dentaire de l’Hôpital Régional de Mamou. Résultats : Dans cette étude, 60 % des patients étaient des hommes contre 40 % de femmes avec un sex-ratio (H/F) = 1,5. Les élèves/étudiants ont été les plus touchés soit 53,6%, la région maxillaire a été la plus concernée avec un taux de 67,5% dont au 62% au niveau du bloc incisivo-canin supérieur. Les traitements ont été chirurgicaux orthopédique et médicamenteux, l’avulsion dentaire a été la plus pratiquée soit 36,8% et la réduction plus la contention dans 24 cas soit 19,2% et l’évolution a été jugée favorable dans 98,4% des cas. Conclusion : Les traumatismes alvéolo-dentaires présentent une diversité clinique, considérés comme un problème de santé publique en raison de leur fréquence dans la société et de leurs impacts négatifs sur la qualité de vie.
Introduction: Dental trauma is considered a public health problem due to its frequency in society and its negative impacts on quality of life. The objective of this study was to contribute to the study of alveolo-dental trauma related to road accidents. Methods: This is a prospective descriptive study from July to December 2019 involving 125 patients admitted to the dental office of the Mamou Regional Hospital. Results: In this study, 60% of patients were men versus 40% women with a sex ratio (M/F) = 1.5. Students were the most affected, i.e. 42.4%, the teeth of the maxillary region with a rate of 67.5% of cases, the upper incisor-canine block was the most affected in 62% of cases. The treatments were surgical, orthopedic and medicinal, dental extraction was the most practiced, i.e. 36.8% and reduction plus retention in 24 cases, i.e. 19.2% and the evolution was considered favorable in 98.4% of cases. Conclusion: Alveolo-dental trauma presents a clinical diversity, considered as a public health problem because of its frequency in society and its negative impacts on the quality of life.
Restauration des dents antérieures au centre de simulation et de prise en charge odontologique de l’Université Gamal Abdel Nasser de Conakry 2022
Authors: Condé M , Nabé AB , Koné I , Ugai D , Doré M , Doumbouya M , Délamou A.
Published: February 2025

Introduction : La reconstitution des dents antérieures est une technique permettant de rétablir les dents antérieures dans leurs formes initiales à l'aide d'un matériau d'aspect similaire de l'émail. L’objectif de cette étude était d’évaluer les besoins en restauration des dents antérieures au centre d'odontologie de l'université Gamal Abdel Nasser de Conakry 2022. Méthodes : Une étude transversale rétrospective a visé descriptif d'une durée de (1) mois allant de septembre-octobre 2022 a été menée. Nous avons ciblé dans cette étude l'ensemble des patients reçus dans le centre d’odontologie durant notre période d'étude. Résultats : La carie dentaire représentait 73,19 % des cause de pertes de substances ayant nécessité la restauration des dents antérieures. Le sexe féminin était le plus dominant soit 53,31% avec un sex ratio 0.87. Les incisives centrales maxillaires étaient les dents les plus restaurées avec 49,86 %. Le motif de consultation le plus représenté était l'esthétique avec 59 %. La technique directe était la restauration la plus utilisée avec 98,64 % et le concept sans stratification était la méthode la plus utilisée avec 99,12 %. Le composite microhybride était utilisé à 100%. Conclusion : la restauration des dents antérieures constitue un vrai défi pour le praticien, car la stratégie de traitement ultraconservateur étant très variée et chaque jour plus nombreuses, il est difficile pour le praticien de faire le choix de la meilleure technique en alliant économie tissulaire et exigences fonctionnelles.
Introduction: Anterior tooth restoration is a technique for restoring anterior teeth to their original shapes using a material similar in appearance to enamel. The objective of this study was to assess the needs for restoration of anterior teeth at the dental center of the Gamal Abdel Nasser University of Conakry 2022. Methods: A retrospective cross-sectional study aimed to be descriptive with a duration of (1) months from September-October 2022 was conducted. In this study, we targeted all patients seen in the dental center during our study period. Results: Dental caries represented 73.19% of the causes of substance loss requiring restoration of anterior teeth. The female gender was the most dominant at 53.31% with a sex ratio of 0.87. The maxillary central incisors were the most restored teeth with 49.86%. The most common reason for consultation was aesthetics with 59%. The direct technique was the most used restoration with 98.64% and the nostratification concept was the most used method with 99.12%. The microhybrid composite was used 100%. Conclusion: the restoration of anterior teeth constitutes a real challenge for the practitioner, because the ultraconservative treatment strategy being very varied and more numerous every day, it is difficult for the practitioner to choose the best technique by combining tissue economy and requirements. functional.
Assessment of the enzymatic and biodegradation potentials of polyethylene degrading microbes isolated from two composite sites
Authors: Okanlawon T.S. , Agbaje I.S. , Okanlawon K.P. , Okafor C.A. , Olufemi S.E. , Adeyemo S.M.
Published: February 2025

This study investigated the viability of composting for actively breaking down synthetic polymer nylon by fungal and bacteria species. A total of thirty (30) samples were taken over the course of three months from two composting sites that contained different coloured polyethylene bags. The identification and characterization of isolates was done using morphological and biochemical techniques while the Analytical Profile Index (Biomeuriex API kit) was used to confirm the identities of the isolates. The overall load of heterotrophic bacteria varied between 3.30 x 104 cfu/g to 1.50 x 106 cfu/g, while that of fungi ranged from 1.02×104sfu/g to 1.26×106sfu/g. Pseudomonas sp. showed the highest prevalence (30%), followed by Staphylococcus sp. (16%). The least frequently occurring bacteria were Micrococcus varians and Proteus mirabilis (4% each). The most common species of fungi were Aspergillus niger (25%) and Fusarium sp. (23.33%), while Aspergillus candidus exhibited the lowest prevalence (3.33%). There was an increase in the temperature of the compost from 24° C to 29 °C in the two sites and an increase in the pH from 6.7 to 7.7. The percentage reduction in weight of white nylon is 6.7% in site 1 and 6.4 % in site 2, the blue nylon reduced by 9% in site 1 and 8.5% in site 2. There was 8.1% loss in weight in yellow nylon in site 1 and 7.5% weight loss in site 2. The black nylon reduced in weight by 8.7% in site 1 and 8.1% in site 2. The enzyme activity showed Fusarium sp. (++) and Aspergillus niger (++) having the highest cutinase activity while the lowest activity was observed in the bacteria. It can be concluded that the combined activity of microorganisms and their enzymes play a major role in the biodegradation of polyethylene which is a major nuisance in the environment.
The synergistic effect of Ocimum gratissimum and Gongronema latifolium extracts on lipid profile of hyperlipidemic induced rats
Authors: Uzor S. , Godwin U. E. , Uzor I. , Okoroiwu H. U. , Aniokete U. C. , Nwadum F. E. , Igwe B. N. , Orinya O. F. , Okezie O. A. , Obasi E. , Nwedu A. B. , Oshibe J. D. , Igwe D. O. , David C. C. , Imakwu I. I. , Ude T. U.
Published: February 2025

Accumulation of excess fat has great adverse health implications, including tissue damage and disorders affecting the liver, brain, bone marrow, and other vital organs. Cardiovascular diseases are known to be strongly associated with increased level of blood lipids. To mitigate this risk, there is a growing interest in exploring natural interventions, such as herbal extracts. This study aimed to evaluate the synergistic effects of Ocimum gratissimum and Gongronema latifolium extracts on the lipid profile of hyperlipidemic rats, addressing the increasing concern of hyperlipidemia-related health issues. This research involved the collection of fresh leaves from Ocimum gratissimum and Gongronema latifolium, which were subsequently processed to obtain plant extracts. The experiment had five groups: Group A was the normal control, Group B represented the hyperlipidemic control, Group C received Ocimum gratissimum extract, Group D was given Gongronema latifolium extract, and Group E received a combination of both extracts. These extracts were administered orally to hyperlipidemic rats, and their effects on lipid parameters were closely monitored. The lipid profile parameters were expressed as mean ± standard deviation, analyzed using one-way ANOVA. A post Hoc test was employed to separate the comparison of mean. The study included key lipid indicators including low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (TC), and triglycerides (TG). The findings revealed substantial improvements in the lipid profiles of rats treated with the combined extracts of Ocimum gratissimum and Gongronema latifolium. Notably, there was a significant reduction (p<0.05) in LDL, TC, and TG levels, while HDL levels were elevated. The results suggest that these plant extracts possess the potential to ameliorate hyperlipidemia and consequently promote cardiovascular health. In conclusion, this research highlights the promise of Ocimum gratissimum and Gongronema latifolium extracts as natural interventions for managing hyperlipidemia. However, further studies with larger sample sizes, extended treatment durations, and dose-response investigations are warranted to provide a more comprehensive understanding of the effects and mechanisms of these extracts.
Potential of anthill soils and their bacteria as a viable source of soil amendment, biofertilizer, and biocontrol
Authors: Enagbonma B. J. , Imade E. E.
Published: February 2025

The escalating costs of synthetic fertilizers and their harmful environmental impacts have sparked a growing interest in exploring sustainable alternatives for crop cultivation. This investigation explored the potential of soil from anthills as a nutrient-rich resource for use in soil amendment, biological fertilizers, and biocontrol applications. Anthill soils and nearby areas were examined for their nutrient content and bacterial diversity. The microbial isolates were also examined for plant growth-promoting (PGP) attributes by employing standard analytical procedures and cultural approaches. To test for the antagonistic properties of the screened microbial isolates against Fusarium oxysporum, the diffusible substance method was used. The results revealed that anthill soils possess higher total bacterial counts and superior physicochemical properties compared to adjacent soils, except for silt, sand, and pH levels. The study identified beneficial bacteria from genera such as Bacillus and Pseudomonas, which exhibited plant growth-promoting properties and antagonistic activity against soil Fusarium oxysporum. These findings suggest that anthill soils are nutrient-rich and harbour beneficial bacteria that can promote plant growth and suppress soil pathogens.
Bioinformatic analysis of some natural antihypertensive compounds from medicinal plants as promising inhibitory agents against Angiotensin-Converting Enzyme
Authors: Fawibe O.O. , Agunbiade F. , Chukwurah P.N. , Akinyemi O.F. , Obiwole E.T. , Ilem D.O. , Bamigboye T.O.
Published: February 2025

Angiotensin Converting Enzyme (ACE) inhibition has been a promising avenue for anti-hypertensive drug development. Our study investigated the inhibitory potential of bioactive compounds derived from six medicinal plants (Allium sativum L., Zingiber officinale Roscoe, Acalypha godseffiana Mast., Moringa oleifera Lam., Vernonia amygdalina Delile, and Rauvolfia vomitoria Afzel.) against ACE using in silico methods. Thirty-one (31) bioactive compounds were screened while Ramipril, and Enalapril were employed as control drugs. 3D structures and canonical Simplified Molecular Input Line Entry System (SMILES) of the bioactive compounds and control drugs were obtained from the PubChem online server. Drug-likeness assessment of the bioactive compounds and protein-ligand docking of successful compounds were conducted using SwissADME online server and AutoDock Vina software. ADMET (absorption, distribution, metabolism, excretion, toxicity) analysis was also done to evaluate the suitability of the hit ligands for further drug development. Of the 31 compounds screened, 17 passed at least four of the five standard rules of drug-likeness determination, while the control drugs (Ramipril and Enalapril) failed one of the rules. Ajmaline, Apigenin, Quercetin, Cryptolepine, Luteolin, Hydroxyvernolide, Kaempferol and Vernodalol had higher binding energies of -9.6 kcal/mol, -8.7 kcal/mol, -8.5 kcal/mol, -8.4 kcal/mol, -8.4 kcal/mol, -8.3 kcal/mol, -8.3 kcal/mol and -7.8 kcal/mol, respectively than Ramipril and Enalapril (-7.6 kcal/mol, and -7.5 kcal/mol). The higher binding energies and the stability of their binding interactions denote these hit ligands as potential antihypertensive drugs targeting ACE. However, wet lab experimental investigation is necessary to validate the inhibitory activity of these compounds and elucidate their mechanisms of action.
Environmental risk and biosafety of genetically modified plants
Authors: Yahaya U. , Suleiman R.A. , Hussaini Y. , Hamidu S.T. , Odey B.O. , Adaaja B.O.
Published: February 2025

Genetic engineering and biotechnology research have produced novel plant and animal products that benefit humankind. This review assesses the environmental risk and biosafety of genetically modified crops. Debates on the advantages and disadvantages of genetically modified crops have a significant impact on public discourse around them. Biotechnology advocates emphasize how it may treat illnesses, prevent malnutrition, lessen hunger, and enhance general health and quality of life. However, there are a lot of issues to biotechnology with some critics oppose it on moral and ethical grounds, others claim that it poses threats to human health and the environment. Agricultural goods that are herbicides resistant and can withstand abiotic challenges like salinity, high temperatures, frost, and drought as well as biological pressures can be produced via genetic modification. Products utilizing gene-editing technology have generated debate and raised questions about the possible dangers of applying these novel methods to genetic alteration for the environment and general public's health. Regarding the evaluation and risk management of genetically modified organisms, there is no definitive consensus. Numerous accords have been released that emphasize the need of biosafety in safeguarding biodiversity; the most significant of them is the United Nations Convention, known as the Cartagena-Columbia Protocol on Biosafety, which was issued in 2000. Despite the potential and enormous benefits of biotechnologies, the issue of the products of these technologies is receiving great international attention due to the potential risks they could pose to human health and the environment.
Utilization of Plastic Wastes in The Production of Pavement Blocks: A Study on Mechanical Properties
Authors: Jajere F A , Nwufo B T
Published: February 2025

This study investigates the utilization of plastic wastes, such as high-density polyethylene (HDPE), poly propylene (PP), and polyethylene terephthalate (PET) in the production of pavement block. These plastic were mixed in different ratios with cement, sand, and stone dust to produce durable and cost-effective blocks.The plastic wastes was shredded, melted (1700C-2900C), and mixed with fillers. The mixture was cast into moulds and tested for hardness and compressive strength). Significant improvements were observed: enhanced hardness (134N/mm2,), satisfactory compressive strength (33.03N/m2) compared to conventional blocks hardness 53.3N/mm2 and compressive strength 5.08N/m2) the plastic pavement blocks demonstrated superior performance. This research demonstrates the potential of plastic waste in construction, offering a sustainable solution for waste management and environmentally friendly infrastructure development.
Enhancing Competitive Edge through Strategic Procurement: Exploring the Influence of Corporate Governance
Authors: Ackah David , Issah Ofori , Eric Dadzie Boafo
Published: February 2025

Strategic procurement, a vital component for organizational competitiveness, has been a subject of continuous exploration, yet it presents mixed findings in research literature. The ambiguity mainly revolves around the moderating role of corporate governance in the relationship between strategic procurement and competitive advantage. This study is dedicated to unraveling this relationship, applying the resource-based view as its theoretical underpinning. Utilizing a quantitative approach and conducting a survey on a sample of 136 employees from manufacturing firms in Ghana, the research offers substantial insights. The findings reveal that strategic procurement has a definite positive impact on competitive advantage, reinforcing the importance of deliberate procurement strategies in business performance. Furthermore, corporate governance, a vital aspect of organizational structure, not only enhances competitive advantage directly but also acts as a strengthening force on the effect of strategic procurement on competitive advantage. It highlights the synergistic relationship between governance practices and procurement strategies. These results emphasize the recommendation for organizations to embrace and implement strategic procurement practices aligned with strong and transparent governance policies. The intertwining of these two aspects may foster organizational success and sustainability. The importance of this study is accentuated by its contribution to filling existing gaps in the procurement literature, particularly regarding the moderating role of governance. By addressing this significant aspect, the research adds valuable insights that may guide both academic discourse and practical applications in the industrial sector, enhancing the understanding of strategic procurement in modern organizational dynamics.
Impact of Covid 19 Pandemic on the Management of Construction Projects in Malawi
Authors: Joseph Mfuni Geofrey
Published: February 2025

Construction projects were massively disrupted by the Covid 19 pandemic. The pandemic significantly affected how construction activities are carried out on site. This study investigated in depth the challenges construction teams faced while managing the projects amidst the COVID 19 pandemic.  The study collected data using a google form questionnaire. The questionnaire was distributed to 52 respondents in total who were actively involved in the management of the construction projects. The collected data was analysed using SPSS software version 26. Findings indicate that the COVID 19 pandemic caused disruption in the management of projects. The construction sites were abandoned by foreign skilled labours and left unskilled local workers on site. Results indicate that it was impossible to work on site because of the imposed restriction measures. Work was done online but proved to be a challenge since one needs to be on site to make decisions about activities. People lost jobs, lives and the local economy was disrupted. Supply chain of construction materials was disrupted because ports and boarders were closed.  The study recommends that projects must procure materials in advance, develop a policy of training local labours to transfer skills, encourage local manufacturing and workers to be vaccinated.
Initiation précoce a la sexualité : un facteur de socialisation chez des jeunes filles scolarisées à Abidjan
Authors: YAO N’Guessan Louis Franck
Published: February 2025

Les rapports sexuels précoces et leurs conséquences (risques sanitaires, grossesses précoces) peuvent limiter l'éducation des jeunes filles dans le cadre scolaire en Côte d'Ivoire. L’ampleur de ce fléau en milieu adolescent suggère que les cadres formels de socialisation (famille, école) ont atteint leurs limites en termes d’éducation et de transmission des valeurs relatives à la sexualité aux jeunes. En milieu urbain, les groupes de pairs jouent également un rôle important dans le développement de la sexualité des jeunes. Le but de cette étude est d'analyser les mécanismes par lesquels les groupes de pairs en milieu urbain influencent l'initiation à un comportement sexuel dès le plus jeune âge chez les jeunes filles. Cette étude mixte (quantitative-qualitative) a été menée auprès de jeunes filles scolarisées au secondaire. Elles ont été sélectionnées grâce aux techniques de boule de neige et d'échantillonnage volontaire dans la commune de Yopougon. Les résultats de cette étude ont permis d'une part d'identifier des points de vue partagés et comportements valorisés en matière de sexualité au niveau des groupes de pairs, d'autre part d’expliquer comment la perte de la virginité et la sexualité active sont déterminantes dans l’appartenance et l’acceptation d’une jeune fille au sein d’un groupe de pairs.
La santé par et pour la communauté : diagnostic socio-anthropologique du paradigme Agent de Santé Communautaire en Côte d’Ivoire
Authors: Zié Adama OUATTARA
Published: February 2025

Dans la perspective de l’Objectif de Développement Durable n°3 visant à « donner aux individus les moyens de mener une vie saine et aider au bien-être de tous à tous les âges », la recherche de solutions aux problèmes d’accès aux soins est une préoccupation qui cristallise l’attention des humanitaires. Cet article propose un diagnostic critique du paradigme Agent de Santé Communautaire (ASC) exploité par des humanitaires en vue de réduire les inégalités d’accès aux soins en Côte d’Ivoire. Une étude qualitative combinant l’entretien semi-directif, l’observation directe, la revue documentaire a permis de collecter le matériau auprès des acteurs humanitaires, des populations bénéficiaires et des communautaires en interaction dans la mise en oeuvre de cette approche en Côte d’Ivoire. Comme résultats, la recentralisation de la santé par le transfert des compétences aux acteurs communautaires que sont les ASC est une innovation qui permet de réduire les inégalités sociales d’accès aux soins et de renforcer la résilience des communautés. Toutefois, l’analphabétisme de certains acteurs communautaires, le manque d’autonomie financière et de motivation, les difficultés logistiques impactent l’efficacité et la pérennité de cette innovation. La pérennisation du paradigme ASC nécessité une mutation du bénévolat vers l’institutionnalisation des ASC en leur accordant un statut professionnel. Cela implique également la mise en place d’un dispositif et de mécanismes de recrutement et de formation de ces communautaires.
La santé digitale en Afrique : entre mythe et réalité
Authors: Boubacar Bilcha Mohamed
Published: February 2025

Ce sujet s’inscrit dans le cadre de l’introduction des Nouvelles Technologies de l’Information et de la Communication (NTIC) dans le système sanitaire dans le monde et particulièrement en Afrique. Cette réalité qui contribue à l’amélioration des pratiques de soins rencontre des défis majeurs à relever en Afrique dont les réalités infrastructurelles restent encore inadaptées dans certaines localités. Cet article, dans sa démarche descriptive et analytique, examine les implications des nouvelles technologies dans le domaine de la santé en Afrique. C’est dans ce sens que les résultats attendus ont montré que la santé digitale dans le monde africain n’est pas exempte de défis et de limites : elle est ainsi un mythe parce que le monde rural africain n’a pas accès aux facilités digitales en matière de santé et réalité dans le monde africain urbanisé qui offre des opportunités pour la pratiquer. Il a été ainsi démontré que le taux de la digitalisation sanitaire est encore faible en Afrique. Le taux de couverture est estimé à 17,75 %. Ces chiffres, obtenus à partir des données sur les régions africaines, montrent que la santé digitale est relativement moins importante en termes de couverture globale.
Empirical investigations towards establishing a geoid-based vertical datum over South Africa
Authors: Mphuthi Matthews Siphiwe , Odera Patroba Achola
Published: February 2025

This study investigates prospects for establishing a geoid-based vertical datum in South Africa and aligning it with the International Height Reference System (IHRS) to modernise and unify vertical positioning. Employing the SAGEOID10 quasigeoid model alongside 138 GPS/levelling data points, this research evaluates the compatibility of spheroidal orthometric, normal, and orthometric height systems with the current quasigeoid and derived geoid models. The assessment is carried out using vertical datum offsets modelled at 100 and validated at 38 GPS/levelling points by applying a four-parameter planar model.  The cross-validation results show that the normal and orthometric height systems provide a best fit, with standard deviations of ±5.1 and ±3.9 cm on quasigeoid and geoid models, respectively. The spheroidal orthometric height system referred to the land levelling datum (LLD) used over South Africa provided a better fit with the quasigeoid (±6.3 cm) than with the geoid (±7.6 cm). In addition, the study determined linear vertical datum offsets between the IHRS and variants of the local vertical datum (LLD, local quasigeoid and local geoid) on four tide gauge benchmarks (TGBMs) around South Africa. Empirical tests on a few benchmarks observed around each TGBM followed. The linear offsets at each TGBM, between each local height system and the global vertical datum (IHRS), revealed similar trends for the quasigeoid and geoid, but not for the LLD. The transformed heights (on the IHRS) were used to determine datum offsets based on benchmarks around each TGBM. Compared to the other three TGBMs (PEL, ELN and DBN), the results show the smallest mean offset around the TGBM in Cape Town. They also indicate that either normal or orthometric height systems should be adopted over South Africa and that the TGBM at CPT should be adopted when transforming a selected local height system to the IHRS.
Computational Vision in Photogrammetry for Georeferencing: Modern Resources Evaluation for UAV Image Processing
Authors: De Sousa Henrique Lima
Published: February 2025

Environmental Science aims to understand the world; this can be achieved by using geographic information systems (GISs). Also, georeferencing allows for the adjustment and alignment of raster data in combination with other GIS data. Thus, it is possible in terms of these techniques to interpret these types of data and their relationships, patterns, and trends. This study aims to investigate the use of modern engineering procedures, known as computational vision in photogrammetric image processing, as obtained from unarmed aerial vehicles (UAV). This is done via a small camera in the front of an embedded system and combined with proprietary software that uses computational vision resources. Although open-source software was the prioritized choice, the research began with a study on state-of-the-art computational vision algorithms and photogrammetry for drone inspection.  The generation, processing, and verification of a set of photographic images were further procedures accompanying the study of the algorithms and photogrammetry which subsequently resulted in a georeferencing system. In fact, proprietary software employing computational vision resources was used in this study at the Universidade de Trás-os-Montes e Alto Douro in Portugal to compare it with the conventional methodology using modern computational resources to determine the benefits achieved. In conclusion, the positional quality of the generated georeferencing system was verified, and satisfactory results were reported. This underscored the potential of these modern computational resources in contemporary photogrammetry.
The Website of Jean-Philippe Toussaint, or Highlighting the Creative Environment
Authors: Chang Ya Ting
Published: February 2025

Jean-Philippe Toussaint’s website (http://www.jptoussaint.com/) distinguishes itself from others due to several characteristic features. Notably, it houses an extensive collection of manuscripts while deliberately excluding any form of literary creation. This analysis focuses on Toussaint’s website within his representative work, Marie’s cycle (2002–2013). This cycle, written concurrently with other projects – such as Autoportrait a l’etranger (2000) and Made in China (2017) – exemplifies his autoreflexive tendencies. The website itself was established in 2009. Marie’s cycle not only exhibits narrative circularity through its textual framework but also underscores Toussaint’s meticulous attention to material and textual forms. Central to this exploration is the prioritization of reader mobility. Similar traits manifest in the structure and functionality of his website. Here, Toussaint embarks on a deliberate quest for digital forms specific to the Internet – an endeavor that resonates with his enduring preoccupation with form. The website employs formal devices intrinsic to the digital realm to perpetuate reading mobility. Moreover, Toussaint’s website serves as an exhibition, and its thematic coherence is centered around the creative process. As an author deeply captivated by backstage processes, he accords significant importance to the creative environment’s material and immaterial aspects.
HECUBA IN THE CONTEMPORARY WORLD: MARINA CARR’S USAGE OF REPORTED SPEECH
Authors:   University of Szeged, Jaber Soltan
Published: February 2025

Marina Carr relocates Euripides’ Hecuba from a women-empowering myth into a
twenty-first century colonial piece. Her choice stems from the fact that she “writes in
Greek” (McGuiness, 2003) and highlights “contemporary issues through the plight of
a marginalised, gendered individual” (Kurdi, 2010). Her rewriting centers around the
Irish colonial struggle by introducing a new, vulnerable Hecuba who loathes war and
reveals colonial motifs. What Carr also does is employ reported speech throughout the
play to replace dialogue that is “at the heart of every dramatic encounter, whether in
theatre or in the classroom” (O’Neil, 1989). Her usage of reported speech invites the
audience to investigate the different motifs behind it. In Carr’s adaptation, the whole
play is written in reported speech. Carr, I assume, experiments with a new narration
method that was exclusive to messengers as a part of their duty of delivering a message.
She instead reconstructs this way of narrating to include monarchs and noblemen
like Agamemnon and Odysseus. Her play centers around ancient colonial motifs and
agenda that still exist in our days. Furthermore, according to Greg Myers (1999),
“reported speech both depicts the experience of the original utterance and detaches
reported utterance from the reporting speaker”, which contributes to the objectivity
of the story. In view of that, my research will focus on the motifs behind the use of
reported speech as a way of voicing the silenced, providing evidence, shifting the
frame, and acquitting Hecuba.
MUSIC IN BLACK AND WHITE
Authors:   University of South Bohemia, Mustafa Salim
Published: February 2025

Rather than focusing on literary allusions, this article will explore musical allusions by
exposing the relationship between the songs and the text in Eugene O’Neill’s play All
God’s Chillun Got Wings (AGCGW). The music allusions in the AGCGW contribute
to the plot by making an impact via musical expression. The songs are introduced in the
intervals as an expression of cultural practice, enriching the meaning, understanding,
and knowledge of the text. The songs employed by O’Neill reflect the inner and outer
manifestations of Black and White races. The songs not only justify the behavior of
the characters in the play but also verify that the chronology of the songs explores
the significance of the plot created by O’Neill. In addition, the paper clarifies how
O’Neill has tried to make sense of the connection of music, spirituality, and innocence
by placing the songs in the play and justifying their relationship with the written text.