bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of Exenatide loaded Biotinylated Trimethylated Chitosan/HP-
55 Nanoparticles
Authors: Guo Hejian , Yan Xuehui , Tang Hao , Zhang Xiaoyan
Published: June 2021

Background:

Exenatide(EXE) is an anti-hyperglycemic agent approved for treating type
2 diabetes by the Food and Drug Administration(FDA). However, twice-daily injection of exenatide
is inconvenient for most of the patients.

Objective:

In this study, biotinylated trimethylated chitosan(Bio-TMC) based nanoparticles were
proposed to promote oral absorption of exenatide. Realizing the oral administration of exenatide is
very important to alleviate patient suffering and improve patient compliance.

Methods:

Bio-TMC was synthesized, and the chemical structure was characterized by Fourier
transform infrared (FT-IR) spectroscopy and 1H NMR spectroscopy. Nanoparticles were prepared
through polyelectrolyte interaction in the presence of sodium Tripolyphosphate (TPP) and hydroxypropyl
methylcellulose phthalate (HP-55). Formulations were physically and chemically characterized.
In vitro release was investigated in different pH media. In vivo antidiabetic activities of biotin
modified and non-biotin modified chitosan were evaluated in db/db mice.

Results:

EXE-loaded Bio-TMC/HP-55 nanoparticles were spherical in shape with a mean diameter
of 156.2 nm and zeta potential of +11.3 mV. The drug loading efficiency and loading content were
52.38% and 2.08%, respectively. In vitro release revealed that EXE-loaded Bio-TMC/HP-55 nanoparticles
were released faster in pH 1.2 than pH 6.8 (63.71% VS 50.12%), indicating that nanoparticles
have enteric characteristics. Antidiabetic activity study revealed that after oral administration
to diabetic mice, the relative pharmacological bioavailability (FPharm%) of the biotin modified nanoparticles
was found to be 1.27-fold higher compared to the unmodified ones, and the hypoglycemic
effect was also found to be better.

Conclusion:

Bio-TMC/HP-55 nanoparticles are feasible as oral drug carriers of exenatide and have
the potential to be extended to other drugs that are not readily oral, such as monoclonal antibodies,
vaccines, genes, etc. These would be beneficial to the pharmaceutical industry. Further research
will focus on the biodistribution of Bio-TMC/HP-55 nanoparticles after oral administration.
Adrenocorticotropic Hormone-Independent Cushing Syndrome with Right Adrenal Adenoma and HIV Infection: A Case Report
Authors: Yuan Yuan , Luo Bingfeng , Yi Xiang , Liang Tuo , Lu Zhenquan
Published: June 2021

Background:

Adrenocorticotropic hormone (ACTH)-independent Cushing's syndrome
(CS) with right adrenal adenoma combined with HIV infection has rarely been reported.

Case presentation:

A 39-year-old Chinese male patient with HIV infection was admitted to our
hospital due to increased blood pressure in the previous 2 years and weight gain in the previous 6
months. Endocrinological examinations showed that blood cortisol (8 a.m.) was 22.23 μg/dl, the
level of ACTH (8 a.m.) was less than 1pg/ml and twenty-four-hour urinary cortisol was 1429
μg/24h. ACTH-independent CS was diagnosed based on low ACTH levels (<1.00 pg/ml), a lack of
cortisol circadian rhythms, and unsuppressed cortisol levels by dexamethasone. The ultrasonography
and multislice spiral computed tomography scan revealed a right adrenal mass. Due to the HIV
status of the patient, we measured the count of CD4+ T helper cells. Laparoscopic right adrenal resection
was performed after the CD4+ T helper cell count was > 200 cells/μl. Subsequent immunohistochemical
staining confirmed right adrenal adenoma.

Results:

The postoperative recovery was good, and wound healing was possible. After surgical
treatment, endocrinological examinations indicated that the level of ACTH increased and the levels
of serum cortisol and twenty-four-hour urinary cortisol decreased, which indicated that CS was controlled.
CD4/CD8 was 0.47 at reexamination, and the patient's immunity was improved.

Conclusion:

Due to the potential side effects of steroid drugs, clinicians should use these medications
with caution and closely monitor the development of adrenal deficiency.
Recent Advances in C-C/Heteroatom Bond Forming and Annulation Reactions of β- Ketodithioesters
Authors: Devi Laishram M. , Singh Thokchom P. , Singh Okram M.
Published: June 2021

:

β-Ketodithioesters (KDEs) are versatile building blocks for the rapid construction of various heterocyclic
compounds. Quite a good number of successful reactions based on KDEs have been developed in the
past decade for the construction of heterocyclic skeletons under mild conditions. This review covers the new CC/
X bond formation and annulation reactions of KDEs with dielectrophilic or dinucleophilic reagents. Multicomponent
reactions using KDEs to construct various heterocycles are also the major contents in this review.

Objective:

The aim of this review is to bring a fresh perspective on the application of KDEs in organic synthesis
covering from 2013 to 2020.

Conclusion:

From this review, it has been cleared that KDEs have been the object of numerous studies on its
use in heterocyclic synthesis. The presence of different functional groups on this synthon permits the incorporation
of C-C/X sources into the final targets, which is the significant property of KDEs.
Green Synthesis of Silver Nanoparticles Using Datura metel Flower Extract Assisted by Ultrasound Method and Its Antibacterial Activity
Authors: Fatimah Is , Hidayat Habibi , Nugroho Bambang , Husein Saddam
Published: June 2021

Background:

Green synthesis method of nanoparticles has been developed for several years. Besides providing environmental-friendly process, green synthesis of nanoparticles using plant extract provides synergistic effect of the secondary metabolite in such antibiotic activity. The study with an intensification process in nanoparticles formation is also gaining great attention. This research deals with the green synthesis of silver nanoparticles using Datura metel flower extract for the antibacterial agent. The use of ultrasound-assisted method for the synthesis was investigated.

Methods:

Synthesis of silver nanoparticles (AgNPs) using Datura metel flower extract under ultrasound- assisted method has been conducted. Evaluation of the successful synthesis was done using UV-visible spectrophotometry, particle size analyzer, x-ray diffraction, and transmission electron microscopy. The prepared AgNPs were tested as an antibacterial against S. aureus, K. pneumoniae, S. pyogenes, and E. coli.

Results:

The ultrasound-assisted synthesis of AgNPs produces particles ranging from 25-70 nm in size; meanwhile, the reflux method demonstrated the size of 50-170 nm. These particles size represents the effect on the antibacterial activity as the ultrasound-assisted synthesized Ag NPs have higher inhibition zone towards all tested bacteria. Subsequently, these data presented the applicability of Ag NPs synthesis using an ultrasound method as a potential candidate for biomedical applications.

Conclusion:

The profile of UV-Visible spectra and particle size analyses demonstrated the applicability of the ultrasound technique to produce a smaller size of the nanoparticles with higher antibacterial activity.
Application of Support Vector Regression and Time Series Method in
Short-term Power Load Forecasting with Regional Difference
Authors: Fan Guo-Feng , Peng Li-Ling , Dong Song-Qiao , Yu Meng , Hong Wei-Chiang
Published: June 2021

Aims:

The aim of this study is to perform short-term load forecasting.

Background:

Short-term load forecasting plays a key role in power dispatching. It provides basic data
for basic power generation planning and system safety analysis so that the power dispatching work is
more practical and the power generation efficiency is higher.

Objective:

The aim of this study is to ensure the safe operation of the electricity market and relieve the
pressure of supply and demand.

Method:

In this paper, the SVR model is used for short-term load prediction.

Results:

The SVR model has the advantage of minimizing the structural risk and has good generalization
performance for the predicted object. At the same time, the global optimization is ensured, a lot of
mapping calculation is reduced, the actual risk is reduced, and the prediction performance is improved.

Conclusion:

The target model has higher forecasting accuracy than other forecasting models and can
effectively solve the problems of the power market.
Hexavalent Chromium Removal from Electroplating Waste Using Biochitin from L.Vanamme Shrimp Shell Waste
Authors:   Postgraduate Program, Department of Chemistry, Faculty of Science, Brawijaya University, Rosmawati Angelina , Rumhayati Barlah ,   Department of Chemistry, Faculty of Mathematics and Science, Brawijaya University, Srihardyastutie Arie ,   Department of Chemistry, Faculty of Mathematics and Science, Brawijaya University
Published: June 2021

The increasing number of electroplating industries in this globalization era has a negative impact on the environment because of its liquid waste containing high concentrations of hexavalent chromium, Cr (VI). To overcome this problem, biochitin extracted from white shrimp shell waste (L.vanamme) has been used to adsorb Cr (VI) from electroplating waste. Biochitins were extracted through single and sequential fermentation method using L.plantarum and B.thuringiensis bacteria. The optimization process of Cr (VI) removal was done by using biochitin from different methods, at various mass of biochitin, the time of adsorption, and Cr (VI) concentration. Results showed that biochitin produced from the sequential fermentation method could optimally adsorb Cr (VI). By using 2 g of biochitin, Cr (VI) could be removed as much as 51.99 ± 0.41% during 6 hours. At the optimum condition, the selected adsorbent could remove Cr (VI) in the concentration range of 9.38 to 92.39 mg/L, which showed the adsorption capacity of 0.915 mg/g. The capability of biochitin for Cr (VI) removal was reinforced by the SEM EDS images, which show the presence of chromium compounds in the biochitin.
Starch Based Biocomposite from Sago (Metroxylon sagu) with Nano-Chitosan reinforcement : Mechanical and Thermal Characteristics
Authors:   Department of Mechanical Engineering, University of Indonesia, Azadi Athoillah , Supriyadi Sugeng ,   Department of Mechanical Engineering, University of Indonesia, Herawati Heny ,   Indonesian Center for Agricultural Post Harvest Research and Development (ICAPOSTRD)
Published: June 2021

A biocomposite system incorporating sago starch and nano-chitosan (SS/NCS) were developed by casting and solvent evaporation method. The purpose of this experiment for characterization of the film based on sago starch (SS) with a variation of the addition of nano-chitosan (0, 2, 4, 6 and 8% by weight starch) and analyze its effect on mechanical properties, thermal properties, and morphological characteristics of mixed film (SS / NCS). Possible intermolecular interactions between SS and NCS were confirmed by Fourier-transform infrared spectroscopy (FTIR) and the reduction of crystallinity in XRD. The experimental data showed that the incorporation of nano-chitosan resulted in an increase in film solubility, tensile strength and elongation at break and a decrease in Young’s modulus. Elongation at break of the (SS/NCS) films increased with increasing of nano-chitosan concentration. The water vapor permeability (WVP) of (SS/NCS) films increased with an increase of chitosan concentration and the same tendency observed for the moisture content. Based on thermogravimetric analysis (TGA), the percentage of nano-chitosan content in starch-based films can increase thermal stability.. Scanning electron microscope (SEM) shows the surface morphology and interface of NCS/SS composite films and suggests sufficient homogenization of starch and chitosan in biodegradable composite films.
Enduring the Autoimmune Aporia of Democratic Sovereignty
Authors: Mihkelsaar Janar
Published: June 2021

The aim of this article is to read Rogues, in order to show that Derrida is neither a philosopher of democracy nor a critic of sovereignty , but rather a thinker of democratic sovereignty. Taking my cue from his Aporias, I argue that democratic sovereignty is aporetically in excess over itself, for it is based on articulating the path through the im-possible passage from the unconditional injunction of the ‘promise’ to the exigency of sovereignty. That is why it can neither be absorbed into the conditions of any existing democracy nor abstracted into any pure identity of sovereignty. Political trends today fail in enduring the aprioricity of aporia, as neoliberals valorize the posited conditions of existing democracy and populists the objective pregivenness of the ‘people’.
Crisis as the New Normal
Authors: Barbi Guido
Published: June 2021

Review of Jürgen Link, Normalismus und Antagonimus in der Postmoderne. Krise, New Normal, Populismus, Göttingen: Vandenhoeck & Ruprecht 2018.
The Trails Making Test. Does a Single Trial Reflect Performance Capability?
Authors:   Department of Psychology, Swansea University, Swansea, McKeown Kate , Richards Emma ,   Centre for Innovative Ageing, Swansea University, Swansea, Richardson Jessica ,   Department of Psychology, Swansea University, Swansea, Tales Andrea ,   Centre for Innovative Ageing, Swansea University, Swansea
Published: June 2021

Information processing speed (Reaction time, RT) to a single administration of the Trails A and Trails B components of the Trail Making Test (TMT) is used in the assessment of brain and behavioural functional integrity across the lifespan in both clinical and research contexts. Although the clinical utility of such single trial-related and thus rapidly gained results, is recognised, it is possible that its administration as a single trial only, precludes its ability to provide a more in-depth and thus relevant representation of functional integrity per se, and it does not allow a range of ability to be examined. Because outcome from a single trial can be susceptible to the influence of spurious and extraneous effects we examined how, within a single testing session, RT varied with respect to the administration of four trials of both Trails A and B of the TMT, and how the effects may be associated with anxiety and self-consciousness. We examined how RT varied with respect to the administration of four trials of the Trail making test and compared the performance over each of these trials with that of the first trial. Between the third and fourth trial, questionnaires on anxiety and self-consciousness were administered. This paradigm was tested with fifty five younger adults (age range eighteen - thirty years). Our results indicated that repeating both Trails A and B of the TMT, administering the tests over four trials, revealed a significantly disproportionately slowed information processing speed (RT) to the first compared to consecutive trials, with the effect greatest for the more difficult or resource-demanding Trails B test. There were no significant correlations between change in information processing speed and anxiety or self-consciousness. The first of the four trials represents the only trial typically performed in the clinical application of this test. Our finding that the time to complete one single trial can be significantly slower compared to the response to additional trials, indicates that an individuals’ information processing speed can appear much slower than their actual ability. Such findings can be expected to be of particular relevance to the future use of this test clinically when an individual’s performance is measured and judged with respect to possible diagnosis, and in future research when group-level TMT performance is compared between younger and older adults for example.
Plane Waves Scattered by a Spherical Inclusion in a Half Space of Poroelastic Material
Authors:   Department of Mathematics , College of Education, Konkuk University , Seoul, Korea, Lee Doo-Sung
Published: June 2021

This paper concerns a poroelastic half-space in which plane compressional waves are scattered by a spherical inclusion. Addition theorems for the spherical wave functions are utilized to meet the boundary conditions on the plane, and the satisfaction of the given conditions on the boundary of the sphere leads to three infinite series equations, whose solution can be acquired by successive approximations. Further, its existence and uniqueness are discussed.
Data Missing Not at Random in Mobile Health Research: Assessment of the Problem and a Case for Sensitivity Analyses
Authors: Goldberg Simon B , Bolt Daniel M , Davidson Richard J
Published: June 2021

Background

Missing data are common in mobile health (mHealth) research. There has been little systematic investigation of how missingness is handled statistically in mHealth randomized controlled trials (RCTs). Although some missing data patterns (ie, missing at random [MAR]) may be adequately addressed using modern missing data methods such as multiple imputation and maximum likelihood techniques, these methods do not address bias when data are missing not at random (MNAR). It is typically not possible to determine whether the missing data are MAR. However, higher attrition in active (ie, intervention) versus passive (ie, waitlist or no treatment) conditions in mHealth RCTs raise a strong likelihood of MNAR, such as if active participants who benefit less from the intervention are more likely to drop out.

Objective

This study aims to systematically evaluate differential attrition and methods used for handling missingness in a sample of mHealth RCTs comparing active and passive control conditions. We also aim to illustrate a modern model-based sensitivity analysis and a simpler fixed-value replacement approach that can be used to evaluate the influence of MNAR.

Methods

We reanalyzed attrition rates and predictors of differential attrition in a sample of 36 mHealth RCTs drawn from a recent meta-analysis of smartphone-based mental health interventions. We systematically evaluated the design features related to missingness and its handling. Data from a recent mHealth RCT were used to illustrate 2 sensitivity analysis approaches (pattern-mixture model and fixed-value replacement approach).

Results

Attrition in active conditions was, on average, roughly twice that of passive controls. Differential attrition was higher in larger studies and was associated with the use of MAR-based multiple imputation or maximum likelihood methods. Half of the studies (18/36, 50%) used these modern missing data techniques. None of the 36 mHealth RCTs reviewed conducted a sensitivity analysis to evaluate the possible consequences of data MNAR. A pattern-mixture model and fixed-value replacement sensitivity analysis approaches were introduced. Results from a recent mHealth RCT were shown to be robust to missing data, reflecting worse outcomes in missing versus nonmissing scores in some but not all scenarios. A review of such scenarios helps to qualify the observations of significant treatment effects.

Conclusions

MNAR data because of differential attrition are likely in mHealth RCTs using passive controls. Sensitivity analyses are recommended to allow researchers to assess the potential impact of MNAR on trial results.
Improving Electronic Survey Response Rates Among Cancer Center Patients During the COVID-19 Pandemic: Mixed Methods Pilot Study
Authors: Hathaway Cassandra A , Chavez Melody N , Kadono Mika , Ketcher Dana , Rollison Dana E , Siegel Erin M , Peoples Anita R , Ulrich Cornelia M , Penedo Frank J , Tworoger Shelley S , Gonzalez Brian D
Published: June 2021

Background

Surveys play a vital role in cancer research. During the COVID-19 pandemic, the use of electronic surveys is crucial to improve understanding of the patient experience. However, response rates to electronic surveys are often lower compared with those of paper surveys.

Objective

The aim of this study was to determine the best approach to improve response rates for an electronic survey administered to patients at a cancer center during the COVID-19 pandemic.

Methods

We contacted 2750 patients seen at Moffitt Cancer Center in the prior 5 years via email to complete a survey regarding their experience during the COVID-19 pandemic, with patients randomly assigned to a series of variations of prenotifications (ie, postcard, letter) or incentives (ie, small gift, modest gift card). In total, eight combinations were evaluated. Qualitative interviews were conducted to understand the level of patient understanding and burden with the survey, and quantitative analysis was used to evaluate the response rates between conditions.

Results

A total of 262 (9.5%) patients completed the survey and 9 participated in a qualitative interview. Interviews revealed minimal barriers in understanding or burden, which resulted in minor survey design changes. Compared to sending an email only, sending a postcard or letter prior to the email improved response rates from 3.7% to 9.8%. Similarly, inclusion of an incentive significantly increased the response rate from 5.4% to 16.7%, especially among racial (3.0% to 12.2%) and ethnic (6.4% to 21.0%) minorities, as well as among patients with low socioeconomic status (3.1% to 14.9%).

Conclusions

Strategies to promote effective response rates include prenotification postcards or letters as well as monetary incentives. This work can inform future survey development to increase response rates for electronic surveys, particularly among hard-to-reach populations.
Результати ендопротезування суглобів при хондросаркомі кістки
Authors: Protsenko V.V. , Buryanov О.A. , Obada Bishtawi , Solonitsyn Ye.О. , Litun Yu.N.
Published: June 2021

У статті повідомляється про результати ендопротезування суглобів при хондросаркомі кістки. У результаті проведеного ендопротезування суглобів у 28 хворих ортопедичні ускладнення спостерігалися у 2 (7,1 %) пацієнтів та рецидиви пухлини у 2 (7,1 %) пацієнтів. Інфекційні ускладнення спостерігалися в 1 хворого, виконано видалення ендопротеза, встановлено цементний спейсер, через 6 місяців виконано реедопротезування кульшового суглоба. Асептична нестабільність ніжки ендопротеза спостерігалася в 1 пацієнта після ендопротезування колінного суглоба, виконано реендопротезування суглоба. При рецидиві хондросаркоми, який виявлено у 2 хворих в строки від 18 до 53 місяців, 1 пацієнту виконано ампутацію нижньої кінцівки на рівні середньої третини стегна, 1 пацієнту виконано ампутацію нижньої кінцівки на рівні нижньої третини стегна, у 3 хворих при дедиференційованій та мезенхімальній хондросаркомі з метастазами в легені проводились курси поліхіміотерапії з наступною метастазектомією. Функціональний результат кінцівки залежно від локалізації пухлини (за шкалою MSTS) після ендопротезування становив від 68,4 до 89,2%. Якість життя хворих за опитувальником EORTC QLQ-30 підвищилась з 40–50 балів до ендопротезування і становила в середньому 85–90 балів після ендопротезування. Загальна трирічна виживаність пацієнтів при хондросаркомі — 95,3 ± 1,7 %, п’ятирічна — 89,7 ± 2,1 %. При мезенхімальній і дедиференційованій хондросаркомі трирічна виживаність становила 0 %.
Вплив препаратів кріоконсервованої плаценти на перебіг неспецифічного гонартриту в експерименті
Authors: Pelypenko O.V. , Shepitko V.I.
Published: June 2021

Актуальність. Лікування патології суглобів як дегенеративного, так і травматичного генезу — процес тривалий, багатокомпонентний, завжди вимагає спільних зусиль лікаря та пацієнта. Вибір оптимальних засобів терапії складний та неоднозначний. Біологічно активні речовини — одні з потужних засобів боротьби із запальним процесом, що є постійним супутником пошкодження. Завдяки своїм антиоксидантним, імуномодулюючим та регенеративним властивостям фрагменти плаценти визнані перспективним засобом лікування артропатій різної етіології. Мета дослідження — визначення морфологічних характеристик складових структур колінних суглобів щурів у нормі в умовах експериментального артриту та після введення кріоконсервованої плаценти. Матеріали та методи. Експериментальне дослідження проводилось на 115 білих щурах. З інтактною групою (10 тварин) порівнювались 3 контрольні групи по 35 тварин кожна, яким виконувались: 1) моделювання каргінаніндукованого асептичного запалення колінного суглоба; 2) підшкірна імплантація фрагмента плаценти; 3) підшкірна імплантація фрагмента плаценти на фоні асептичного запалення колінного суглоба. Гістологічні препарати готували за загальними методиками із забарвленням гематоксиліном та еозином та за Ван Гізоном. Результати. При створенні запального вогнища зміни в хрящовій тканині визначались із третьої доби у вигляді лакунарності, каріопікнозу як етап некробіозу хондроцитів, що був особливо виражений із 10-ї до 14-ї доби. Морфологічні зміни кісткової тканини щурів, яким вводився ƛ-карагінан, відмічались на 7-му добу дослідження у вигляді резорбції та деструкції кісткових балок. У подальшому (10-та доба) запальний процес призводив до картини фрагментованої архітектоніки кісткової тканини, що спостерігалась до 21-ї доби. Із боку синовіальної оболонки спостерігаються гіперплазія ворсин, лімфоїдна інфільтрація, поява додаткових шарів синовіїцитів як результат проліферативної реакції. Найбільш виражені зміни спостерігались у покривному шарі синовіальної оболонки. При однократному введенні кріоконсервованої плаценти ознаки запалення вірогідно зменшувались: обмежувалась площа деструкції хряща та кістки, у синовіальній оболонці знижувались ознаки мукоїдного набухання. Процеси функціонального кровонаповнення мікроциркуляторного русла переважали над ішемічними. Стимуляція регенеративних процесів забезпечувала структурне відновлення на 21-шу добу спостереження. Висновки. Препарати кріоконсервованої плаценти впливають на перебіг запального процесу в умовах експериментального остеоартриту. Найбільш вірогідний терапевтичний ефект визначається з боку синовіальної оболонки.
Teachers’ Inclusive, Augmentative, Assistive and IT Competences in Working with Children with Special Educational Needs
Authors: Milic Tamara
Published: June 2021

In this study we wanted to determine the presence of teachers’ information-communication-technological competencies in working with students with special educational needs. Desk research provides an overview of policy and support in inclusive education in Montenegro, with a focus on teachers’ inclusive training. From 2015 to 2018, 148 trainings were realized in the field of inclusive education and 3848 teachers were trained - most often, these were one-day trainings, duration - 8 hours, and the topics were: Working with specific disabilities, adaptation, individualization. Systematic observation based on a protocol was conducted with 15 children from the second to the sixth grade of primary school: autism; intellectual, visual, hearing, combined disabilities and difficulties: speech, language, reading and writing. The findings indicate that teachers are educated to an individualize approach. We observed the application of the approach and the use of learning and communication technology. The effects of teachers’ work and competencies are better after training, coaching and when they get support from the professional associates of the school and/or resource center. Teachers’ attitudes are positive, they show creativity, adaptability, use the technologies after they have been trained about the characteristics of students, and recommended approaches for working with them.
Evaluación de la calidad del servicio en las clínicas de la Licenciatura en Estomatología de la BUAP: metodologías SERVPERF y Donabedian
Authors: López Ramírez Edith , Sifuentes Valenzuela Ma. Cristina , Lucero Rodríguez Rebeca , Aguilar Sonia Lilia , Perea González Gloria Patricia
Published: June 2021

Objetivo: comparar la percepción de la calidad funcional de los pacientes que acuden a los servicios en las Clínicas Estomatológicas de Docencia y Servicio (CEDS), con las metodologías Donabedian y SERVPERF. Diseño metodológico: se realizó un estudio descriptivo, transversal, observacional y prolectivo para comparar cómo perciben los pacientes atendidos en las CEDS de la Facultad de Estomatología (FE) de la Benemérita Universidad Autónoma de Puebla (BUAP) la calidad del servicio, a partir de las metodologías Donabedian y SERVPERF. Se diseñó y aplicó a una muestra aleatoria estratificada de 400 pacientes un instrumento denominado PERCACEL estructurado en tres partes: a) datos generales; b) metodología de evaluación de Donabedian; y c) metodología SERVPERF.Resultados: el porcentaje de percepción de la calidad con el instrumento Donabedian fue menor (8.14 %) en comparación con el obtenido con la metodología SERVPERF (8.51 %).Limitaciones de la investigación: la validez y confiabilidad del instrumento resultaron altas, sin embargo, su sensibilidad depende de la identificación de los procesos del servicio a evaluar en cada una de las dimensiones de las dos metodologías, para asegurar su confiabilidad.Hallazgos: ambos instrumentos pueden ser utilizados en diferentes servicios, tanto públicos como privados, y en diferentes ámbitos, incluyendo el de estomatología.
Duplex Sign Language Communicator
Authors: Sahane Prof. Prema
Published: June 2021

In this paper we are introducing a sign language converter which works as a duplex system as it can convert text to sign language as well as it can do a real time video to text conversion. It is basically a system that can be used by all people who know sign language as well as who are not familiar with it. The main aim of this system is to involve the specially abled people as much as possible to interact with others. Our system uses the basic NLP i.e. the Natural language Processing and algorithms like CNN classifier to make the implementation of this translator. Along with that this system focuses on the Indian Sign Language so that it can be used by our country people. The finger gestures are captured by the camera and using various machine learning algorithms the system will automatically translate the signs to the readable text, similarly in sign to text conversion, based on the data sets and various Machine learning algorithms the text will be converted to sign language.
Breast Cancer Prediction using CNN and Machine Learning Algorithms with Comparative Analysis
Authors: Voruganti Santhosh
Published: June 2021

At present world, Breast cancer is a second main cause of cancer death in women after lung cancer. Breast cancer occurs when some breast cells begin to raise abnormally. It can arise in any portion of the Breast and it can be prevented if the treatment is started at the early stage of the Breast cancer. Breast cancer is a malignant tumour i.e. a collection of cancer cells arising from the cells of the breast Treatment of breast cancer relies on the cancer type and its stage. Mainly this paper focused on diagnosing the Breast cancer disease using various classification algorithm with the help of data mining tools. Data mining of the intelligent accumulated from previously disease detected patients opened up a new aspect of medical progression In this paper, the focus has been prediction of breast cancer using various machine learning algorithms and visualizing the performances of each algorithm. This paper makes use of a dataset that contains numerical values about the clump thickness, uniformity of the cell for prediction using Multi Layer Perceptron, K-NN, Random Forest, Logistic Regression. Moreover, this also uses a dataset of tissue images for the prediction using Convolution Neural Network. Later, the accuracies of each algorithm is calculated along with the precision, recall, f-score, ROC for each algorithm.
Result Analysis: Remotely Accessible Security System using IoT
Authors: Ahire Swagat
Published: June 2021

In the todays world a strong door locking system is that the first and most important thing to assure security of a home. Due to the increasing workload and daily travelling tasks most of the days people stays out of their houses. In such situations, identifying a visitor and getting remote access to their home is necessary. A smart door lock mechanism which may be completely monitored and controlled from a foreign location using smartphone is proposed during this paper. When a visitor presses bell/push button at the door, a Raspberry Pi with attached camera gets triggered and captures the image to check in database for identification. If found then door will simply open otherwise a notification will sent to the owner with OTP and visitor's image. Now depending upon owners will he/she can give access to visitor by giving system generated OTP.
A Review on Life Cycle Assessment of Solar PV Panel
Authors: Varade Apurva
Published: June 2021

Humans tend to connect the music they hear, to the emotion they are feeling. The song playlists though are, at periods too large to sort out automatically. It would be accommodating if the music player was “smart enough” to sort out the music based on the current state of emotion the individual is feeling. The main idea of this project is to automatically play songs based upon the emotions of the adherent. Based on the emotion, the music will be played from the predefined playlist. It aims to deliver user-preferred music with emotional attentiveness. In the existing system user want to manually select the songs, randomly played songs may not accede to the feel of the adherent, user has to classify the songs into various emotions and for playing the songs user has to manually choose a particular emotion. These difficulties can be avoided by using our project. This is a novel way that helps the handler to automatically play songs based on the emotions of the handler. It recognizes the facial emotions of the adherent and plays the songs based on their emotion. The emotions are recognized using a machine learning method Support Vector Machine (SVM) algorithm. The human twist is an important organ of an individual's body and it especially plays an important role in the heritage of an individual's behaviours and emotional appearance.
Las funciones de las aves en la producción avícola de pequeña escala: el caso de una comunidad rural en Hidalgo, México
Authors: Romero-López Ana Rosa
Published: June 2021

En México, diversos estudios enfatizan que la importancia de la avicultura de pequeña escala en el ámbito rural recae en dos funciones que se les asignan a las aves: 1) aporte a la seguridad alimentaria y 2) generación de ingresos económicos. Pocos son los estudios que identifican y describen las funciones complementarias que tienen las aves en sistemas de producción de pequeña escala y la manera en que dicha especie contribuye al bienestar de la familia productora. En el presente estudio se identificaron y analizaron las funciones que las familias productoras le asignaban a la especie avícola en las 26 unidades de producción que poseían aves, de un total de 29, en la comunidad rural La Cuchilla, Hidalgo, México. Se encontró que las aves podían tener 6 diferentes funciones, no mutuamente excluyentes:  nutrimental (26.9 %), medioambiental (24.4 %), cultural (17.9 %), económica (16.7 %), social (11.5 %) y de recreación (2.6 %). Cada una de las funciones contribuían al bienestar familiar en cinco diferentes esferas: seguridad alimentaria, disponibilidad de recursos económicos, reforzamiento de relaciones sociales, vinculación al mercado y transmisión de conocimientos vernáculos. Se concluye que las aves pueden tener una multifuncionalidad que va más allá de su aporte a la seguridad alimentaria (función nutrimental) y generación de recursos económicos (función económica). Las funciones de las aves pueden ser estrategias que los productores definen para alcanzar el bienestar familiar en cinco diferentes esferas. La comprensión integral del concepto de función es importante para el diseño de estrategias de desarrollo acordes a los objetivos y lógica de producción de la familia productora.
Relationships among ß-hydroxybutyrate, calcium and non-esterified fatty acids in blood with milk yield losses at early lactation
Authors: López-Ordaz Rufino , Pérez-Hernández Gabriela , Ramírez-Ramírez Hugo Alonso , López-Ordaz Reyes , Mendoza-Martínez Germán David , Ruíz-Flores Agustín
Published: June 2021

The objectives were to study the associations of concentrations of β-hydroxybutyrate acid (BHBA), calcium (Ca2+), and non-esterified fatty acids (NEFA) in blood serum 7 d prepartum with losses in milk yield (MY) and metabolic dysfunctions at seven and 14 d of lactation. Three hundred and thirty-six (336) Holstein-Friesian (780 ± 36 kg BW; which had lactated more than twice) were sampled by coccygeal venipuncture, 7 d before, and 7 and 14 d after parturition. For each sample and metabolite serum concentrations were stratified in thresholds and related to MY. When BHBA levels were high 7 d before parturition and were related to MY at d-7 postpartum, it was observed that 11.00 % of the cows lost 0.370 kg d-1 of milk. In contrast, no relationship was observed between BHBA prepartum and MY on d-14 of lactation. It was not observed any association between high NEFA and low Ca2+ levels prepartum and MY. NEFA concentrations ≥ 0.5 mmol L-1 on d-7 before calving were 7.6 more susceptible for lameness incidence (P≤ 0.01), and when BHBA ≥ 0.8 mmol L-1 cows were 2.4 times more likely to develop ketosis (P≤0.05) in the first 60 d in milk. In brief, data indicate that a high proportion of cows are above the thresholds of β-hydroxybutyrate and non-esterified fatty acids, and are also deficient in calcium, when determined one week before parturition. The risk thresholds for each metabolite were not associated with the amount of milk lost at d-14 after calving.
Actividad antihelmíntica in vivo de hojas de Acacia cochliacantha sobre Haemonchus contortus en cabritos Boer
Authors: Castillo-Mitre Gastón Federico , Rojo-Rubio Rolando , Olmedo-Juárez Agustín , Mendoza de Gives Pedro , Vázquez-Armijo José Fernando , Zamilpa Alejandro , Lee-Rangel Héctor Aarón , Avendaño-Reyes Leonel , Macías-Cruz Ulises
Published: June 2021

El objetivo del presente trabajo fue evaluar el efecto de la inclusión de hojas de Acacia cochliacantha en una dieta de mantenimiento para cabritos de la raza Boer en el conteo fecal de huevos (CFH) de Haemonchus contortus, consumo de agua y materia seca. Diez cabritos recién destetados (16.850 ± 1.630 kg de peso vivo inicial y 3 meses de edad), fueron experimentalmente infestados con larvas (L3) de H. contortus (350 larvas por kilogramo de peso vivo), para probar dos tratamientos: T1: testigo (animales infectados con larvas L3 de H. contortus, sin inclusión de hojas de A. cochliacantha) y T2: animales infectados con larvas L3 de H. contortus, con inclusión de 5% hojas de A. cochliacantha en la dieta. Antes de asignar los tratamientos a los animales, se realizó un CFH por gramos de heces en cada uno de ellos y de esta manera agruparlos de mayor a menor en relación a la cantidad de huevos presentes en las heces, en los dos animales con valores más altos se asignaron aleatoriamente T1 o T2 y así sucesivamente hasta completar cinco repeticiones verdaderas para cada tratamiento. Las variables medidas fueron: CFH (por gramo de heces), consumo de agua y consumo de materia seca (CMS). Los resultados encontrados demostraron reducción (P<0.05) en el CFH de H. contortus en los cabritos donde se incluyó el 5% de hojas de A. cochliacantha en su dieta. Para el consumo de agua y CMS (g día-1) no existieron diferencias entre tratamientos (P> 0.05). Se concluye que la adición de hojas de A. cochliacantha en dietas para cabritos tienen actividad antihelmíntica, por lo que esta leguminosa arbórea podría representar una opción en el manejo integral de la nematodiasis de cabritos Boer en crecimiento.
Detección de anticuerpos de Neospora spp. en caballos, asociados a diferentes factores de riesgo en México
Authors: Padilla-Díaz Kenia Jasher , Medina-Esparza Leticia , Cruz-Vázquez Carlos , Vitela-Mendoza Irene , Gómez-Leyva Juan F. , Quezada-Tristán Teódulo
Published: June 2021

Neospora spp. es un parásito protozoario causante de abortos y enfermedad del Sistema Nervioso Central (SNC) en diversas especies domésticas y silvestres. En equinos, se le ha involucrado como causa de aborto, mortalidad neonatal y enfermedades del SNC. La especie identificada en equinos es distinta a Neospora caninum y se denomina Neospora hughesi. El objetivo del presente, fue detectar la presencia de anticuerpos anti-Neospora spp., asociados a factores de riesgo en caballos de México. Se realizó una encuesta de cada cuadra y animales individuales de cuatro regiones  del país  (Centro, Norte,  Occidente y  Sur)  para identificación  de los factores de riesgo. Se obtuvo un total de 684 muestras de sueros de caballos de las diferentes regiones, 52.3 % (358) machos y 47.7 % (326) hembras. Los sueros fueron conservados a -20 °C. El diagnóstico se realizó mediante la técnica de inmunofluorescencia indirecta (IFI), los resultados de este fueron analizados para estimar la asociación entre la seropositividad y los factores de riesgo. La seroprevalencia a Neospora spp. fue de 2.34 % en la población estudiada; los casos positivos se encontraron principalmente en tres de las cuatro regiones incluidas, que presentaron una relación significativa a la presencia de anticuerpos anti-Neospora spp.; la convivencia de los caballos con otros animales obtuvo un valor de OR de 2.34 (IC 95%: 0.28 - 19.0; P<0.04). Se concluye que, Neospora spp., está presente en los caballos de México.
Efecto de la selección genética en contra de las emisiones de metano sobre los componentes de la leche
Authors: Calderón-Chagoya Rene , Hernández-Medrano Juan Herberth , Ruiz-López Felipe De Jesus , García-Ruiz Adriana , Vega-Murillo Vicente Eliezer , Mejía-Melchor Enoc Israel , Garnsworthy Phil , Román-Ponce Sergio Iván
Published: June 2021

El objetivo de este trabajo fue estimar la respuesta a la selección a través de diferentes índices de selección entre producción de metano y producción y componentes de la leche en los sistemas de lechería tropical especializada, doble propósito y lechería familiar. El muestreo de las emisiones de metano se realizó durante la ordeña mediante el equipo Guardian-NG. Se tomaron muestras de leche de manera individual durante el muestreo de metano. La extracción de ADN se realizó de folículos pilosos de todos los animales incluidos en el estudio. La estimación de los componentes de varianza y covarianza se realizó mediante la metodología de modelos mixtos. Se utilizaron los marcadores moleculares para construir la matriz de relaciones genómicas (Matriz G), debido a que no se contaba con información genealógica completa. La heredabilidad estimada para las emisiones de metano durante la ordeña fue de 0.18 y 0.32 para los análisis univariados y bivariados, respectivamente. Los resultados de las correlaciones genéticas entre porcentaje de grasa y proteína en leche con las emisiones de metano durante la ordeña fueron negativas, -0.09 y -0.18 respectivamente. La respuesta a la selección estimada mediante los índices de selección demostró que es factible obtener reducciones de hasta 0.021 mg/l de emisiones de metano durante la ordeña en cinco generaciones; lo anterior sin detrimento en los componentes de la leche.
Nivel de infestación de Rhipicephalus microplus y su asociación con factores climatológicos y la ganancia de peso en bovinos Bos taurus x Bos indicus
Authors: Castañeda Arriola Roberto Omar , Álvarez Martínez Jesús Antonio , Rojas Martínez Carmen , Lira Amaya José Juan , Ríos Utrera Ángel , Martínez Ibáñez Francisco
Published: June 2021

El objetivo fue evaluar el grado de infestación natural por Rhipicephalus microplus, así como determinar su correlación con factores climatológicos y su efecto sobre la ganancia de peso en bovinos doble propósito. Se utilizaron 31 bovinos cruzados, Bos taurus x Bos indicus, de ambos sexos, con una edad promedio de 307 días. El conteo de garrapatas semi-repletas (4.5 a 8.0 mm de diámetro) y el pesaje de los animales se realizaron cada 28 días. El conteo de garrapatas se realizó desde la cabeza hasta la base de la cola, abarcando miembros anteriores y posteriores, así como la región ventral de los animales. Las variables de respuesta estudiadas fueron número de garrapatas semi-repletas y ganancia de peso promedio del animal. En julio el número promedio de garrapatas por animal fue mayor (P<0.05) que en el resto de los meses del año. Por el contrario, el sexo y el grupo racial del animal no afectaron (P>0.05) el número de garrapatas. La ganancia de peso disminuyó 34 g (P<0.05) por cada garrapata semi-repleta por periodo. El número de garrapatas tuvo una correlación baja (P<0.01) con la temperatura ambiental y humedad relativa; ganancia de peso promedio correlacionó negativa y moderadamente con el número de garrapatas (-0.67; P<0.01). Los bovinos con un nivel de infestación alto (61 garrapatas o más) tuvieron una ganancia de peso promedio menor (P=0.001) que aquellos con nivel de infestación medio (31 a 60 garrapatas) y bajo (0 a 30 garrapatas). La infestación de bovinos de doble propósito con Boophilus microplus requiere un control más estricto en los meses de mayor temperatura ambiental (abril a julio).
Четыре принципа нормативной архитектуры Китая
Authors: Шевченко Марианна
Published: June 2021

Нормативная архитектура Китая, или архитектура «гуань- ши», наряду с народной, представляет собой одну из двух важнейших составляющих частей китайского зодчества. Термин «гуаньши» состоит из двух иероглифов: 官 (гуань) -  административный, казённый, государственный; и 式 (ши) - образец, норма, стандарт, эталон, тип. Архитектура «гу­аньши» - это архитектура, соответствующая определённым государственным нормативам, соблюдению которых уделя­лось особое внимание со стороны императорского двора. К нормативной архитектуре относились императорские и административные постройки, а также крупные монастыри, храмы, захоронения, резиденции знати, важные фортифика­ционные сооружения и другие. Иными словами, принадлеж­ность к разряду нормативной архитектуры не была связана с функцией построек, а также с их географическим положением на территории Поднебесной.

В данном исследовании нормативная архитектура Китая рассматривается как единое феноменальное явление, основу которого составляли четыре базовых принципа: модульность, иерархичность, пространственная регулярность и единство числовых и геометрических пропорций. В статье кратко рас­крыто содержание данных принципов, исследован процесс формирования нормативной архитектуры, который начался на рубеже IV-III тысячелетий до н.э. и завершился к VI веку нашей эры. Вскрыта связь четырёх принципов с различными аспектами традиционного китайского мировоззрения. Вы­явлен преемственный характер формирования и развития нормативной архитектуры. Кроме того показано, почему ар­хитектура, не обладающая одним или несколькими базовыми принципами, не может быть отнесена к разряду нормативной и как в этом случае меняется её характер.