bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence of metabolic phenotypes among citizens of Arctic area of the Russian Federation (in Arkhangelsk city setting)
Authors: Postoeva A. V. , Dvoryashina I. V. , Kudryavtsev A. V. , Postoev V. A.
Published: May 2023

BACKGROUND: Influence of obesity on the body at whole and with regard to metabolic changes is still unclear. In Russia there are a few data about prevalence of metabolic phenotypes among population based on epidemiological data.

AIM: to assess the prevalence of metabolic phenotypes among citizens of Arctic area of the Russian Federation (in the Arkhangelsk city setting).

MATERIALS AND METHODS: a cross-sectional study was conducted using a random sample of Arkhangelsk citizens (n=2380) 35–69 years old, which was obtained within a population study of cardiovascular diseases («Know your heart» (KYH)). The participants were divided into metabolic phenotypes according to the presence of obesity (BMI≥30 kg/m2) and metabolic syndrome (AHA/NHBLI): phenotype 1 — metabolically healthy normal weight, phenotype 2 — metabolically unhealthy normal weight, phenotype 3 — metabolically healthy obesity, phenotype 4 — metabolically unhealthy obesity.

RESULTS: 2352 participants of KYH were included in the study, 982 (41,8%) men and 1370 (58,3%) women. Mean age was 53,9 (SD 9,7) years. The distribution of participants by metabolic phenotypes was as follows: 1167 (49,6%) persons had phenotype 1, 489 (20,8%) — phenotype 2, 248 (10,5%) — phenotype 3, 448 (19,1%) — phenotype 4. In men, the second common after the first phenotype was phenotype 2, while in women, the second position was shared by the 2nd and 4th phenotypes, which had approximately the same frequency. «Arterial hypertension» was the most prevalent component of metabolic syndrome and seen in 68–96% men and 38–94% women in the study with different phenotypes. The proportions of phenotypes with metabolic disorders increased with age.

CONCLUSION: in a study of a random population sample within the framework of the concept of metabolic phenotypes, a half of the participants had no obesity and metabolic syndrome. Proportions of participants with metabolic disorders with and without obesity was 20% each. Only 10% of participants had «metabolically healthy» obesity. If excluding individuals without obesity and metabolic syndrome, the phenotype characterized by metabolic disorders in the absence of obesity was the most common among men. Phenotypes with metabolic disorders on the background of obesity or without obesity were equally common among women. The most common component of metabolic syndrome was «arterial hypertension». There was a tendency of accumulation of metabolic disturbances with age.
A case of 17-beta-hydroxysteroid dehydrogenase deficiency type 3 in adult endocrinologist practice
Authors: Molashenko N. V. , Kalinchenko N. Yu. , Ioutsi V. A. , Gurinovich O. S. , Babaeva D. M. , Voznesenskaya A. A. , Platonova N. M. , Yukina M. Yu. , Kolodkina A. A. , Ponomareva T. A.
Published: May 2023

17β-Hydroxysteroid dehydrogenase 3 deficiency (17HSD3) is a rare autosomal recessive cause of 46, XY disorders of sex development resulting from HSD17B3 gene mutations, in which conversion of androstenedione to testosterone is impared. The clinical signs of 17HSD3 deficiency depend on the residual activity of the enzyme. The diagnosis of 17HSD3 deficiency is based on reduced testosterone/androstenedione ratio (T/AD < 0.8). Patients are usually assigned at birth and raise as female. If the diagnosis is made before puberty, gonadectomy is recommended, taking into account the risk of masculinization during the puberty and estrogen therapy initiation in this period. If the diagnosis of 17HSD3 deficiency is established during puberty, when virilization manifests, the therapeutic strategy is based on the results of comprehensive psychological testing and gender identity of a patient. In patients with more pronounced masculinization or diagnosis established shortly after birth, who are assigned at birth and raise as male, testosterone therapy is used to achieve a male phenotype. The 17HSD3 deficiency and virilization often result in a change of gender identity during puberty. The article presents a clinical case of 17-βhydroxysteroid dehydrogenase type 3 deficiency with late diagnosis due to parental will. The diagnostic approaches and management of the disease are also described.
SPECT/CT with 99mTc-Tectrotide in the diagnosis of insulinoma
Authors: Yukina M. Yu. , Troshina E. A. , Nuralieva N. F. , Degtyarev M. V. , Mokrysheva M. G.
Published: May 2023

BACKGROUND: Insulinoma is a pancreatic neuroendocrine tumor that manifests by impaired carbohydrate metabolism with the development of hypoglycemic syndrome. The instrumental methods used at the present stage do not always make it possible to identify a tumor; moreover, the data obtained often contradict each other. Thus, the search for new possibilities of visualization of insulinoma is relevant.

AIM: Evaluation of diagnostic effectiveness of scintigraphy with single-photon emission computed tomography combined with X-ray computed tomography (SPECT/CT) with 99mTc-Tectrotide for insulinoma in a Russian cohort of patients.

MATERIALS AND METHODS: A single-centre (Endocrinology Research Centre of the Ministry of Health of the Russia), experimental, single-stage, controlled study. In the years 2017–2021 patients with pancreatic insulinoma (group 1) and hyperinsulinemic hypoglycemia of a different genesis (group 2) with negative or contradictory results of the 1st line imaging methods (ultrasound, magnetic resonance imaging (MRI), computed tomography (CT)) were included. All participants underwent the whole-body scintigraphy and low-dose SPECT/CT with 99mTc-Tectrotide (500–900 MBq). The studies were performed on a tomograph of the SPECT/GE Discovery NM/CT 670 using low-energy high-resolution collimators (LEHR) in the «whole body» mode.

RESULTS: In the group 1 (n=21), according to the results of a pathomorphological study, the presence of 26 insulin-producing tumors was confirmed. Group 2 included 9 patients. According to the SPECT/CT with 99mTc-Tectrotide, 14 tumors were diagnosed in group 1 out of 26 insulin-producing tumors of the pancreas, and negative results were obtained in group 2 in 100% of cases. Thus, the sensitivity and specificity of the method were: 54%, 95% CI [33%; 73%] and 100%, 95% CI [68%; 100%], respectively.

CONCLUSION: SPECT/CT with 99mTc-Tectrotide can detect insulinoma in 54% of cases with negative or contradictory results of 1st-line imaging methods (ultrasound, MRI, CT). This study can be effectively used as an alternative to SPECT/CT with 111In-octreotide, as a 2nd-line method for topical search for an insulin-producing pancreatic tumor.
Robust Rayleigh quotient minimization and generalized eigenvalue problems
Authors: Schanze Henrik
Published: May 2023

We study the problem of minimizing the non-linear trace quotient trace(V^TG(V)V)/trace(V^TH(V)V) over the Stiefel manifold of all n x p matrices with orthonormal columns. Hereby we assume G(V) and H(V) to be symmetric and positive definite for all V. In this way we generalize the robust Rayleigh quotient optimization introduced by Bai et al. in the article "Robust rayleigh quotient minimization and nonlinear eigenvalue problems". We show a possible way to minimize the nonlinear trace quotient by joining and generalizing different known techniques, e.g. the SCF-iteration, and examine it by testing a small example.
USO DA GAMIFICAÇÃO NO ENSINO DA ENGENHARIA DE PRODUÇÃO: JOGO DE TABULEIRO BASEADO NOS DESPERDÍCIOS LEAN
Authors: Araujo Andressa , Pimentel Cristiane , Oliveira Daniel
Published: May 2023

A mais recente resolução das Diretrizes Curriculares Nacionais do Curso de Graduação em Engenharia, instituída em 24 de abril de 2019; torna necessário o uso de metodologias que estimulem a aprendizagem ativa do aluno. Metodologias ativas, como a técnica da gamificação, tem comprovada efetividade nas mais diversas áreas e níveis de escolaridade. Assim, o objetivo deste relato de experiência é discorrer sobre o desenvolvimento de um jogo de tabuleiro baseado nos sete desperdícios existentes na metodologia Lean, como intuito de disseminar este conhecimento com alunos do ensino superior e médio. O percurso metodológico escolhido foi a técnica de gamificação, na qual utiliza de métodos e dinâmicas de jogos para o processo de ensino e aprendizado. Sua escolha permitiu como resultado a criação e materialização do jogo denominado “Jogo dos sete desperdícios”, além do registro deste nas bases do Instituto Nacional de Propriedade Industrial (INPI) como desenho industrial, o que permite que ele possa ser aplicado e validado junto ao público-alvo futuramente.
ESTRATÉGIA DE CURRICULARIZAÇÃO DA EXTENSÃO: EXPERIÊNCIAS NAS DISCIPLINAS DE ENGENHARIA ECONÔMICA E PESQUISA OPERACIONAL NA UFABC
Authors: Abensur Eder , Sciolny Juliana , Hesky Gustavo
Published: May 2023

Este trabalho apresenta uma estratégia para discussão da curricularização da extensão baseada nas experiências das disciplinas de Engenharia Econômica e de Pesquisa Operacional ministradas na Universidade Federal do ABC (UFABC) que combinou o conteúdo didático destas matérias com ações orientadas à solução de problemas práticos de comunidades externas à universidade com uso coordenado e equilibrado dos recursos acadêmicos disponíveis. Os resultados obtidos traduziram-se em relevantes aplicações para as comunidades intermediadas pelos alunos.
IMPLEMENTAÇÃO DE MELHORIAS NOS RELATÓRIOS DAS ATIVIDADES EXTENSIONISTAS DO CURSO DE ENGENHARIA DE PROUÇÃO DA UNINTER
Authors: Vieira Everton , Agostinho Douglas
Published: May 2023

As diretrizes estabelecidas pela resolução 07/2018 do Ministério da Educação, trouxe à tona as atividades extensionistas na organização curricular dos cursos de graduação, que as Instituições de Ensino Superior deviam se adequar. Isto foi um grande desafio, onde 10% da carga horária total deve ser destinada as atividades extensionistas, para inserir os alunos nos problemas sociais na comunidade onde estão inseridos, ajudando a resolvê-los. No curso de Engenharia de Produção da Uninter, as atividades extensionistas foram desenvolvidas no contexto da logística reversa, que é uma atividade presente na realidade de todos no mundo. Com isso, surgiram desafios para elaboração das atividades que foram transformadas em disciplinas, com o desenvolvimento das atividades as entregas dos trabalhos eram realizadas, foi percebido que duas das quatro disciplinas estavam com entrega dos trabalhos abaixo do esperado e alguma ação deveria ser tomada. O objetivo deste relato de experiência é mostrar como o curso de Bacharelado em Engenharia de Produção da Uninter, na modalidade a distância, implementou melhorias para aumentar o percentual de entregas nos relatórios das atividades extensionistas 2 e 3. Como solução proposta foram realizadas simplificações nos relatórios das atividades visando a utilização de alguns elementos da ferramenta plano de ação (5W2H), após a implementação das melhorias foi possível perceber o aumento no percentual de entregas das atividades.
An Intelligent Intrusion Detection System for Internet of Things Attack Detection and Identification Using Machine Learning
Authors: Othman Trifa S. , Abdullah Saman M.
Published: May 2023

The usability and scalability of Internet of things (IoT) technology are expanding in such a way that they facilitate human living standards. However, they increase the vulnerabilities and attack vectors over IoT networks as well. Thus, more security challenges could be expected and encountered, and more security services and solutions should be provided. Although many security techniques propose and promise good solutions for that intrusion detection systems IDSs still considered the best. Many works proposed machine learning (ML)-based IDSs for IoT attack detection and classification. Nevertheless, they suffer from two main gaps. First, few of the works utilized or could analyze an up-to-date version of IoT-based attack behaviors. Second, few of the works can be considered as multi-class attack detection and classification. Therefore, this work proposes an intelligent IDS (IIDS) by exploiting the ability of ML algorithms to classify and identify malicious from benign behaviors among IoT network packets. Three ML classifier algorithms are investigated, which are K-Nearest Neighbor, support vector machine, and artificial neural network. The developed models have been trained and tested as binary and multi-class classifiers against 15 types of attacks and benign. This work employs an up-to-date dataset known as IoT23, which covers millions of malicious and benign behaviors of IoT-connected devices. The process of developing the proposed IIDSs goes under different preprocessing phases and methods, such as null value solving, SMOTE method for the imbalanced datasets, data normalization, and feature selections. The results present IIDSs as good binary and multi-class classifiers even for zero-day attacks.
Miloslav Petrusek a paradox Schrödingerovy kočky
Authors: Šubrt Jiří
Published: May 2023

Review article
Sex and Gender Influence Urinary Symptoms and Management in Multiple System Atrophy
Authors: Bailey Elke Schipani , Hooshmand Sara J. , Badihian Negin , Sandroni Paola , Benarroch Eduardo E. , Bower James H. , Low Phillip A. , Singer Wolfgang , Coon Elizabeth A.
Published: May 2023

Objective Multiple system atrophy (MSA) is characterized by urinary dysfunction, yet the influence of sex and gender on urinary symptoms and treatment is unclear. We sought to characterize sex and gender differences in the symptomatology, evaluation, and management of urinary dysfunction in patients with MSA.Methods Patients with MSA evaluated at our institution were reviewed and stratified by sex.Results While the prevalence of urinary symptoms was similar in male and female patients, incontinence was more common in females. Despite this, males and females underwent postvoid residual (PVR) measurement at similar rates. While catheterization rates were similar when PVR was measured, males were more than twice as likely to be catheterized than females in the absence of PVR measurement.Conclusion Urinary symptoms are common in MSA, but their presentation differs between males and females. The difference in catheterization rates may be driven by a gender disparity in referrals for PVR, which can guide treatment.
Effects of cadmium on the synthesis of active ingredients in Salvia miltiorrhiza
Authors: Fu Haihui , Yuan Jun , Liu Rongpeng , Wang Xiaoyun
Published: May 2023

Cadmium (Cd) could pose threats to human health by affecting Salvia miltiorrhiza (SM) safety. Cd enrichment trait and its effects on the active ingredient synthesis in SM remain unknown. Here we investigated the Cd concentration using ICP-MS-based method, physiologies (contents of malondialdehyde and proline, and activities of superoxide dismutase, peroxidase [POD], and catalase [CAT]), and LC-MS/MS-based metabolites of SM under 25, 50, and 100 mg kg−1 Cd stress. The results revealed that Cd concentrations, as it rose in soil, increased in roots and leaves of SM with transfer factors and bioconcentration factors below 1 in Cd-treated groups; POD and CAT activities and proline content increased and then declined. Amino acids and organic acids (especially d-glutamine [d-Gln], l-aspartic acid [l-Asp], l-phenylalanine [l-Phe], l-tyrosine [l-Tyr], geranylgeranyl-PP [GGPP], and rosmarinic acid [RA]) contributed more in discriminating SM roots of different groups. GGPP was negatively related to l-Tyr and l-Phe, and RA was positively related to d-Gln and l-Asp in SM. These results revealed that SM belonged to a non-Cd-hyperaccumulator with most Cd accumulated in roots, Cd could enhance phenolic acid synthesis via regulating amino acid metabolism and might inhibit tanshinone synthesis by declining the GGPP content, and proline, POD, and CAT played vital roles in resisting Cd stress. These provided new ideas and theoretical basis for further study on medical plants’ response to heavy metals.
The extirpation of medium and large mammal species from the Ehotilé Islands National Park, south-eastern Côte d’Ivoire
Authors: Zausa Diorne , Bogui Elie B. , Akpatou Bertin K. , Koné Inza
Published: May 2023

In West Africa, high deforestation rates and poaching have induced dramatic declines of mammal’s populations and local extinctions. Due to their isolation, island species are more vulnerable than mainland species. The premises of that scenario are perceptible in the Ehotilé Islands National Park, south-eastern Côte d’Ivoire, but have not been documented. This study aimed to update the diversity and conservation status of medium and large mammals in that protected area. Several surveys were conducted between 2019 and 2021, using ethno-zoological interviews and individual surveys with local populations, as well as reconnaissance walks and camera trapping to collect data on the presence or absence of mammals. From interviews with local populations and literature review, a list of 27 species of mammals that were potentially present in the park in the past was established. Most “lost” species are large mammals, especially primates that are globally threatened. A total of 11 species were pictorially identified, including two Near threatened species (Aonyx capensis and Hydrictis maculicollis) and one Vulnerable species (Cercopithecus lowei). The study confirms a trend of population decline and the erosion of mammal diversity in the park, hence highlighting the need for urgent conservation actions.
Assemblage, relative abundance and activity pattern of wild mammals in the human-dominated landscape of Vansda taluka, Gujarat, India
Authors: Dahya Mohmad Navaz , Chaudhary Rohit , Shah Alkesh , Kazi Aadil
Published: May 2023

Conservation of mammals in human-dominated landscapes requires essential information on their ecological aspects. We used camera traps to assess the wild mammal assemblage, their relative abundance, and activity patterns in the human-dominated landscape of Vansda taluka, Gujarat, India. We deployed 80 camera traps in square grids of 2 km2 resulting in an area coverage of 160 km2. To assess the mammal assemblage, relative abundance of species, and activity pattern, respectively, we used a count of species, relative abundance index (RAI), and circular statistics. We captured 13 mammals, including the wild pig, Indian hare, leopard, rhesus macaque, common grey mongoose, small Indian civet, common palm civet, Indian crested porcupine, hanuman langur, chital, barking deer, striped hyena, and jungle cat. The wild pig was the most abundant (RAI = 10.29), while the jungle cat was the least abundant (RAI = 0.04) species. Hanuman langur, rhesus macaque, and chital showed diurnal activity, while striped hyena, barking deer, small Indian civet, common palm civet, and Indian crested porcupine showed nocturnal activity. Leopard, wild pig, common grey mongoose, and Indian hare showed cathemeral activity pattern. The present study serves as a baseline for future studies and help formulate conservation strategies for wild mammals in the study area.
Wear properties of borided WC-Co
Authors: Aydogmus Tuna , Peker Derya , Topuz Polat
Published: May 2023

Today, artificially produced tungsten carbide (WC) tools are used as an alternative to diamonds such as mining, drilling, cutting, or machining. Although it is called WC, it also contains a certain amount of cobalt (Co). The most important reason for this is that it increases the wear resistance of the WC. Boriding is a type of surface hardening method that provides wear, hardness, and corrosion resistance to the applied surface. In boriding, which is a kind of diffusion process, there is no change in the dimensions of the materials since the boride layer grows from the outer surface of the materials to the inside. In this study, the development of surface properties by boriding of 90 wt% WC and 10 wt% Co-containing abrasive bits used for drilling were investigated. The samples were borided in an atmosphere-controlled furnace at 1173, 1273, and 1373 K for 1, 2, and 3 h by the pack boriding method. After the boriding processes, the microstructure, hardness, and chemical composition of the boride layers formed on the surface of the samples were examined, and finally, the wear tests were carried out to reveal the differences compared to the unborided sample.
Crystal structure of catena-poly[bis(μ2-dicyanamide-κ2
N:N′)-bis(4-vinylpyridine-κN)-copper(II)], C18H14CuN8
Authors: Tan Chong , Zhang Tong , Yi Xiaodong
Published: May 2023

C18H14CuN8, triclinic, P1̄ (no. 2), a = 7.2431(5) Å, b = 7.3783(5) Å, c = 9.8740(6) Å, α = 110.174(6)°, β = 105.036(5)°, γ = 92.219(5)°, V = 473.55(6) Å3, Z = 1, R

gt
(F) = 0.0409, wR

ref
(F
2) = 0.1272, T = 293(2) K.
Crystal structure of 3,5–di-O-benzoyl-1,2-O-isopropylidene-α–D-ribose, C22H22O7
Authors: Wu Binbin , Chen Guangying , Ding Haixin
Published: May 2023

C22H22O7, orthorhombic, C2221 (no. 20), a = 8.891(2) Å, b = 17.938(5) Å, c = 25.996(6) Å, V = 4146.0(18) Å3, Z = 8, R

gt
(F) = 0.0461, wR

ref
(F
2) = 0.1189, T = 296 K.
Crystal structure of (E)-3-(3-methoxybenzylidene)benzofuran-2(3H)-one, C16H12O3
Authors: Zheng Liang Liang , Liu Xiong Li , Dong Zhang Chao , Shi Yang , Pan Bo Wen , Feng Ting Ting
Published: May 2023

C16H12O3, monoclinic, P21/c (no. 14), a = 10.9636(14) Å, b = 12.1767(12) Å, c = 10.1557(13) Å, β = 116.588(16)°, V = 1212.4(3) Å3, Z = 4, Rgt
(F) = 0.0366, wR

ref
(F
2) = 0.1019, T = 250.00(10) K.
Effects of PON1 QR192 genetic polymorphism and paraoxonase, arylesterase activities on deep vein thrombosis
Authors: Akbalik Hasim , Polat Muhammet Fevzi , Muderrisoglu Ahmet , Er Zafer Cengiz , Caniklioglu Aysen , Ekim Meral , Ekim Hasan
Published: May 2023

Objectives

We aimed to evaluate PON1 QR192 polymorphism’s (rs662) effects on levels of triglyceride, total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, glucose, and c-reactive protein, and paraoxonase-arylesterase activities among deep vein thrombosis patients and healthy subjects.

Methods

Forty-five deep vein thrombosis patients and 45 healthy subjects participated in the study. Genetic analysis was performed by using polymerase chain reaction and sequencing. Paraoxonase and arylesterase enzyme activities were determined by a spectrophotometer. Serum levels of triglyceride, total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, glucose, and c-reactive protein were measured by a similar method.

Results

There were no statistically significant differences between patients and controls regarding the frequency of variant allele for the PON1 QR192 polymorphism, activities of paraoxonase-arylesterase, and level of high-density lipoprotein-cholesterol. Triglyceride, total cholesterol, low-density lipoprotein-cholesterol, glucose, and c-reactive protein levels were significantly higher in patients compared to controls (p values were 0.005, 0.0002, 0.009, 0.0009, <0.0001, respectively.) Paraoxonase activity was found to be associated with PON1 QR192 genetic polymorphism (p<0.0001). However, we observed no association of PON1 QR192 polymorphism with arylesterase activity and, levels of triglyceride, total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, glucose, and c-reactive protein.

Conclusions

There was no statistically significant difference between deep vein thrombosis patients and healthy subjects regarding variant allele frequency for the PON1 QR192 genetic polymorphism. In addition, paraoxonase and arylesterase activities were similar among the groups. These results indicate that PON1 QR192 genetic polymorphism and activity levels of paraoxonase-arylesterase have no effect on the development of deep vein thrombosis.
Defining the Sport Scientist: Common Specialties and Subspecialties
Authors: Gleason Benjamin H. , Suchomel Timothy J. , Brewer Clive , McMahon Eric , Lis Ryan P. , Stone Michael H.
Published: May 2023

Sport scientist roles are becoming more common in U.S. professional and collegiate sport. Despite the recent growth in opportunities, discussion is necessary to elucidate differences between sport scientist specialties and other roles common within the integrated support team and across the sport industry. In addition, guidance is necessary to show how sport scientists serving in academic appointments may be involved in sport organizations and influence sport systems. This information may be used: (a) to help employers to conceptualize roles and design job descriptions and (b) to help governing organizations and universities establish training programs for sport scientists.
TRÊS MULHERES DO DRAMA DO SÉCULO XIX NAS MULHERES DE NOSSO TEMPO - O CRISTIANISMO COMO OBLITERAÇÃO DAS MULHERES
Authors: Gaiger Paulo
Published: May 2023

O artigo é um recorte do processo desenvolvido no grupo Gênero e Teatro. Neste 2019, foram pinçados da dramaturgia do XIX, três personagens mulheres das peças A dama das Camélias, Casa de Bonecas e Senhorita Júlia. Sobre a realidade contemporânea da mulher, foram selecionadas três crônicas do jornal Diário Popular que abordam a trajetória da mãe e das filhas no ambiente familiar. Nessa direção, Gisele, escrito a partir da história real de Gisele Santos, quase assassinada por seu namorado, integram esta reflexão. Aqui nos propomos a desvelar relações entre as três personagens, as mulheres da trilogia e Gisele, assim como a reflexão de como as relações de poder e sujeição se renovam da forma explícita à dissimulada.Palavras-chave: Teatro; Crônica; Condição feminina; Cristianismo. TRES MUJERES DEL DRAMA DEL SIGLO XIX EN LAS MUJERES DE NUESTRO TIEMPO - EL CRISTIANISMO COMO OBLITERACIÓN DE LAS MUJERES Resumem: El artículo es un recorte del proceso desarrollado en el grupo de géne­ro y teatro. En este 2019, fueron rescatados de la dramaturgia del siglo XIX, tres personajes femeninos de las obras The Lady of Camellias, Doll House y Miss Julia. Sobre la realidad contemporánea de las mujeres, se seleccionaron tres crónicas del periódico Diário Popular que abordan la trayectoria de la madre y las hijas en el entorno familiar. En esta dirección, Gisele, escrita desde la historia real de Gisele Santos, casi asesinada por su novio, es parte de esta reflexión. Aquí proponemos revelar las relaciones entre los tres personajes, las mujeres de la trilogía y Gisele, así como el reflejo de cómo las relaciones de poder y sujeción se renuevan explíci­tamente a los disfrazados.Palabras clave: Teatro, Crónica, Condición femenina; Cristianismo.
O corpo transfigurado: porque a noite é sempre outra
Authors: Torres Lizângela
Published: May 2023

Diante do trabalho Da série Incursões Noturnas – Pátio / 003, por mim realizado em 2008, proponho um relato de processo e a leitura da obra, na qual observa-se a transfiguração do corpo na superfície fotográfica. A desorganização da figura pela captura do movimento suscita a relação com o conceito de corpo sem órgãos de Deleuze e Guattari. A forma espectral da imagem que insiste em séries dissemelhantes, sugere a noção de imagem fantasma, possibilitando a discussão sobre a relação da fotografia com a imagem ícone e a imagem simulacro, diferenciadas por Platão. Para pensar o caráter da fotografia no contexto das Incursões Noturnas, cujas imagens afirmam-se como cópias distorcidas da ação, como a imagem fantasma, propõe-se uma análise do conceito de simulacro em Deleuze, a partir da reversão do platonismo em Nietzsche.Palavras-chave: Fotografia; Noite; Simulacro; Fantasma.The transfigured body: because the night is always other  Abstract: In light of From the series Nocturnal Incursions - Patio / 003, a work produced in 2008, I propose a reporting on process and a reading of the work, in which the body’s transfiguration is observed on the photographic surface. The figure’s disorganization captured in movement evokes the relation with Deleuze and Guattari’s concept of body without organs. The spectral form of the image insists on a dissimilar series and suggests the notion of the phantom image, thus raising a discussion about the relationship of photography with the icon and the simulacrum, images differentiated by Plato. In order to consider the nature of photography in the context of Incursões Noturnas, in which the images assert themselves as distorted copies of the action, as phantom images, this article proposes an analysis of the concept of simulacrum in Deleuze, based on the reversion of Platonism in Nietzsche. Keywords: Photography; Night; Simulacrum; Ghost.
TER UMA IDEIA EM CINEMA: Sobre o ato de criação no cinema brasileiro feito por mulheres
Authors: Langie Cíntia
Published: May 2023

O artigo busca pensar o cinema a partir de algumas ideias do filósofo Gilles Deleuze, sobretudo no que se refere à noção de criação. Como recorte, escolhemos trazer como referências apenas filmes brasileiros dirigidos por mulheres, numa busca por dar protagonismo a obras que muitas vezes ficam esmagadas pelo cinema hegemônico. Para colocar o pensamento em movimento, garimpamos da obra de Deleuze duas noções que irão delimitar os caminhos da análise: vazamento e necessidade. Entre algumas realizadoras citadas, estão Glenda Nicácio, Ana Carolina, Lúcia Murat, Yasmin Thayná e Grace Passô.Palavras-chave: Cinema brasileiro; Mulheres no Cinema; Criação. HAVING AN IDEA IN CINEMA: About the act of creation in Brazilian cinema made by women Abstract: The article seeks to consider cinema in relation to the ideas of the philosopher Gilles Deleuze, especially with regard to the notion of creation. As a thematic approach, we chose to bring up only references to Brazilian films directed by women, seeking to give prominence to works that are often overwhelmed by hegemonic cinema. In order to put our thoughts in motion, we extracted, from Deleuze's work, two notions that will define the paths of analysis: leakage and necessity. Among some of the directors mentioned are Glenda Nicácio, Ana Carolina, Lucia Murat, Yasmin Thayná and Grace Passô.Keywords: Brazilian cinema; Women in the cinema; Creation.
Diferença Preta
Authors: Guedes Pacheco Eduardo
Published: May 2023

Este texto tem por intenção compartilhar um encontro realizado entre as proposições feitas por Gilles Deleuze e alguns traços dos modos de pensar da negritude. Para isso, são tomadas desses as ideias referentes à arte, com especial atenção para a música. A pretensão é criar caminhos para um possível devir negro das ideias deste filósofo. Fazendo parte deste encontro, pensadores como Muniz Sodré, José Carlos dos Anjos e Rincon Sapiência contribuem para que este artigo crie um espaço de compartilhamento de ideias, por sua vez, um Deleuze Preto.Palavras-chave: Diferença Preta; Ritmo; Deleuze.Black DifferenceAbstract: This paper is intended to share a meeting that took place involving proposals falling between those of Gilles Deleuze and some aspects and ways to think about blackness. With this in mind, these have been considered with regard to ideas about art, paying special attention to music. The intention is to create paths for this philosopher’s ideias’ possible black becoming. Also involved in this encounter are thinkers such as Muniz Sodré, José Carlos dos Anjos and Rincon Sapiência whose thought contributes to this article creating a space for sharing ideas, in turn, a Black Deleuze.Keywords: Black Difference; Rhythm; Deleuze.
How the Cereal Crumbles
Authors: Stanga John P. , Nash Troy R. , Pannell Megan D.
Published: May 2023

Concepts relating to enzymes and energy are central to understanding chemical and biological processes at the molecular level. Student learning of these crosscutting concepts can be challenging, so it is important to identify misconceptions and remediate them early, especially in introductory classes. Here we describe an activity in which undergraduate introductory biology students timed themselves crushing pieces of cereal to simulate and quantify the progress of an enzymatic reaction in the presence of competitive and noncompetitive inhibitors, and we asked students to connect the cereal analogy to concepts of thermodynamics. We developed an assessment and short surveys to evaluate the impact of the activity and to identify persistent misconceptions. Measurable improvements of assessment scores and qualitative student survey responses demonstrate the value of including a hands-on activity along with other modes of instruction.
Optimized Design of Source Energy for Manufacturing Machine by Digital Numerical Control
Authors: Ly Duc Minh  , Nguyen Quang Sang  , Petr Bilik  , Radek Martinek
Published: May 2023

The quality of the power supplied to the machining center is a key factor in determining the accuracy of the machine’s operation. The precision of the machining center is to ensure that the spindle accuracy is less than 3 microns. This study proposes a digital numerical control system to control the quality of the power supply and control the accuracy of the spindle axis of the machining center to monitor the measurement results in real time. The computer vision system is set up according to the artificial intelligent (AI) technique to recognize human face objects and control the position of the processor respectively on each line. The online measurement system follows the digital numerical control (DNC) system applied at each processing line, measuring product dimensions, measuring conditions for setting up machining tools, and measuring machine coordinates. The system operates fully automatically, eliminating dependence on operator skill, and facilitating operation in control of machining conditions. Improve machining center operator satisfaction. After implementation of the improvement options, total cost down 1.740 USD per year, the monthly repair cost due to broken drill, spindle alignment decreased from $5000 to $3,300 per month. The scrap rate related to the hole size decreased from 0.47% to 0.23% (cost down $35 per month). Downtime for repair reduced from 20 hours per month to 7.5 hours per month (cost down $10 per month). Broken drill rate was reduced from 0.20% to 0.06% (cost down $100 per month).
Development of a high-performance building material using wood-based corrugated panels manufactured via cold-forming technique
Authors: Pradhan Suman , Mohammadabadi Mostafa , Entsminger Edward , Ragon Kevin , Khademibami Laya , Street Jason
Published: May 2023

A wood-based sandwich panel with a corrugated core was developed as a building material. A matched-die mold manufactured from commercial plywood was used to fabricate the corrugated panels through a cold-forming process. A cold-setting resin was applied on southern yellow pine (Pinus spp.) veneers with an average thickness of 4 mm, and four plies of them were formed into a corrugated geometry using a wooden mold. When the resin was cured, the corrugated panel of veneers retained the corrugated shape after load removal. Facesheets of the sandwich structures were fabricated using three plies of the same veneers. To evaluate the effect of this corrugated geometry on the structural performance, the same veneers — regarding number, thickness, and orientation — used for the sandwich panel were adopted to fabricate laminated flat panels. Both sandwich and laminated flat panels were submitted to a four-point bending test. The results confirmed the sandwich effect, i.e. a 1741% increase in the bending stiffness of sandwich panels compared to that of laminated flat panels. Sandwich panels developed in this study were compared to Structural Insulated Panels (SIPs), wood-framed structures known as stud walls, and sandwich panels produced using a hot-pressing technique. The cold-formed sandwich panels had higher structural performance than commercial building materials.
Parametric analysis on the lateral force resistance of Qing Dynasty timber frame containing stacked purlins
Authors: Chang Yibin , Dai Jian
Published: May 2023

In ancient wooden structures of the Qing dynasty in China, stacked purlins are important longitudinal elements. In this study, a refined finite element model of a four-column timber frame containing stacked purlins was built. The effects of the fangs, spacer boards, and purlins with dovetail ends on the lateral resistance of the timber frame and the mid-span vertical deflection of the purlins were studied. The longitudinal hysteresis curve of the timber frame made up of stacked purlins was found to be S-shaped, centrally symmetrical, with a pinching effect and full at both ends. The Fangs made the greatest improvement on the lateral stiffness, displacement ductility, and total hysteresis energy consumption of the timber frame by reducing the mid-span vertical deflection of the purlins. The spacer boards contributed less to the lateral resistance of the timber frame than Fangs, but they contributed most to the reduction of the mid-span vertical deflection of the purlins. The dovetail connection at the ends of the purlins had a limited effect on reducing the lateral stiffness and ductility of the timber frame and increasing the mid-span vertical deflection of the purlins, but they significantly increased the total energy consumption of the timber frame and its energy consumption capacity.
Properties of heat-treated beech laminated veneer lumber reinforced with carbon fiber fabric
Authors: Perçin Osman , Uzun Oğuzhan
Published: May 2023

Carbon fiber fabric reinforced laminated veneer lumber (RLVL) pieces were prepared by using heat-treated beech (Fagus orientalis Lipsky) veneers with polyurethane (PU) adhesive as the binder. Carbon fiber fabric was tested in three different locations with solid material and non-reinforced samples (on the bottom adhesive line, upper adhesive line, and upper and bottom adhesive lines-symmetrical). Prior to the manufacture of LVL and RLVL, heat treatment was conducted in a laboratory oven at three temperatures. These temperatures were 150, 170, and 190 °C. Tests were performed on LVL and RLVL to determine their air-dried density, modulus of rupture (MOR), and modulus of elasticity in bending (MOE). Experimental test results showed that reinforcement with carbon ﬁber increased the air-dried density, MOR, and MOE. In addition, carbon fiber fabric placed symmetrically close to bottom and upper surfaces gave the highest MOR and MOE values. However, locating the carbon fiber fabric closer to the bottom surface tended to give higher mechanical properties for the reinforced LVL.
Spiritualitas, Kecemasan, dan Stres selama Pandemi COVID-19
Authors: Hamka Hamka , Yusuf Muhammad
Published: May 2023

This study aims to examine the effect of spirituality on anxiety and stress during the COVID-19 pandemic. This study used quantitative method with a spiritual scale measuring instrument and the Depression, Anxiety and Stress Scale (DASS-21). There were 452 participants aged 18-55 years reside in East Kalimantan Indonesia, who were recruited through a random sampling technique. This study found that there was a significant effect of spirituality on anxiety and stress during the COVID-19 pandemic in the people of East Kalimantan Indonesia.
Efektivitas Achievement Motivation Training (AMT) Berbasis Islam dalam Meningkatkan Motivasi Menghafal Alquran Santri
Authors: Baroroh Ema Zati , Firmansyah Dedi , Hasanah Nurul
Published: May 2023

This study aims to examine the effectiveness of Islamic-based Achievement Motivation Training (AMT) in increasing motivation to memorize the Quran. This study used a quantitative pre-experimental method with a one group pretest-posttest design. The participants were 8 teenage boys aged 11-17 years, who were students at Pondok Tahfizh Quran Hisbah Al-Mizan Pontianak who were selected through random sampling. Data collection used a scale of motivation to memorize the Quran with a value of α .7737. Based on the paired sample of t test, a significance value of .004 (p < .05) was obtained, which indicated that there were differences in the level of motivation to memorize the Quran before and after training. Thus the Islamic-based Achievement Motivation Training (AMT) is effective in increasing the motivation to memorize the Quran in students.
PEMBENIHAN IKAN KOI (Cyprinus carpio) SECARA ALAMI DI MINA SUMBER UTAMA KOI
Authors: Ritonga Lusiana BR , Nasuki Nasuki , Sari Lutfia Indah
Published: May 2023

Koi fish is one of the freshwater ornamental fish that has the potential to be developed and has important economic value. opening the market for koi fish seeds is quite high, so the availability of seeds must be available continuously. One way to produce seeds is by spawning. The main parameters observed in this study were fertilization rate, hatching rate and survival rate. The value of the fertilization rate in spawning 1 was 79 and spawning II was 80%. The hatching rate in spawning I was 73% and in spawning II was 87%. The survival rate for spawning 1 was 96% and spawning II was 79%.
Von Hippel-Lindau is Associated to Pancreatic Neuroendocrine Tumors: A Comprehensive Review
Authors: Coco Danilo , Leanza Silvana
Published: May 2023

Multiorgan tumors are a hallmark of the autosomal dominant genetic disorder known as Von Hippel-Lindau syndrome (VHL), which is typically the result of inherited aberrations of the VHL tumor suppressor gene. The most frequent cancer is retinoblastoma, which can also occur in the brain and spinal cord, renal clear cell carcinoma (RCCC), paraganglioma, and neuroendocrine tumors. There may also be lymphangiomas, epididymal cysts, and pancreatic cysts or pancreatic neuroendocrine tumors (pNETs). The most frequent causes of death are metastasis from RCCC and neurological complications from retinoblastoma or central nervous system (CNS). Pancreatic cysts are present in 35–70% of VHL patients. Simple cysts, serous cysts, or pNETs are possible presentations, and the likelihood of malignant degeneration or metastasis is no greater than 8%. Although VHL has been associated with pNETs, their pathological characteristics are unknown. Furthermore, it is unknown whether variations in the VHL gene cause the development of pNETs. Hence, this retrospective study was undertaken with the main aim to examine whether pNETs are connected to VHL from a surgical perspective.
Personalization of Anticoagulant Therapy with Direct Oral Anticoagulants in Patients with Atrial Fibrillation and Chronic Kidney Disease Based on Pharmacogenetic Testing
Authors: Sychev Dmitriy A. , Batyukina Svetlana V. , Ostroumova Olga D. , Mirzaev Karin B. , Kochetkov Alexey I. , Abdullayev Sherzod P. , Sozaeva Zhannet A. , Bochkov Pavel O. , Asoskova Anastasiia V. , Denisenko Natalia P. , Ebzeeva Elizaveta Yu. , Chernyaeva Marina S.
Published: May 2023

Background. Polymorphic variants of the genes encoding these isoenzymes and carrier proteins involved in the pharmacokinetics of direct oral anticoagulants (DOAC) may alter their function and, therefore, hypothetically may increase the risk of bleeding associated with the use of DOAC. Aims to study the possible relationship between the presence of polymorphic variants of ABCB1 (rs2032582, rs1045642, rs1128503), CYP3A5 (rs776746) and CYP3A4 (rs35599367) genes on the residual equilibrium concentration (Cmin,ss /D) of apixaban, CYP3A isoenzyme activity and bleeding development in patients with AF and CKD C3C4 stages. Methods. The study included 142 patients with AF combined with chronic CKD stages C3 and C4, receiving apixaban therapy, aged 58 to 99 years (median age 84 years). Pharmacogenetic, pharmacokinetic testing and assessment of CYP3A isoenzyme group activity were performed. Results. Plasma concentration of apixaban depended on the stage of CKD: a higher level of Cmin,ss /D was observed in patients with CKD stage C4 compared to patients with CKD stage C3a and with CKD stage C3b. When studying the effect of rs1045642 (C3435T) polymorphism of ABCB1 gene on apixaban pharmacokinetics, it was found that carriers of homozygous TT genotype had lower median apixaban concentration in blood compared to carriers of CC and TC genotypes (p = 0.027 and 0.034 respectively). For rs2032582 polymorphism of ABCB1 gene, we recorded that patients with GG genotype had higher Cmin,ss /D level of apixaban compared to GT genotype carriers (p = 0.037). CYP3A metabolic activity was statistically significantly lower (p = 0.036) in the group with a history of bleeding compared with that in patients in the group without a history of bleeding (0.8 (0.5; 1.3) and 1.2 (0.7; 2.1); p = 0.036). CYP3A metabolic activity did not differ between patients with different CYP3A5 (rs776746) and CYP3A4 (rs35599367) polymorphism genotypes. For the rs1045642 polymorphic variant, there were fewer carriers of the heterozygous TC genotype (16 (45.7%) patients) among patients with bleeding during the follow-up period compared to patients with no bleeding (43 (53.1%) patients; p = 0.024). Conclusions. The results of the study indicate the presence of an association between genome-wide changes (polymorphic variants of the ABCB1 (rs1045642) and CYP3A5 (rs776746) gene and the presence of apixaban-associated bleeding in patients with AF and CKD stages 34. Mechanisms of such an association require further study.
Autoimmune and Autoinflammatory Genesis of Myocarditis and Pericarditis
Authors: Myachikova Valentina Yu. , Maslyanskiy Alexey L. , Mairina Sofia V. , Mitrofanova Lubov B. , Kostareva Anna A. , Moiseeva Olga M.
Published: May 2023

Myocarditis and pericarditis are common pathologies in the general population, which pose significant challenges to practitioners for both diagnosis and treatment due to the unique characteristics of diagnosis verification and lack of clear understanding of the diseases pathogenesis. This publication discusses the primary mechanisms of inflammatory diseases development of the myocardium and pericardium based on innate and acquired immunity disorders, including data from our research confirming the autoimmune and autoinflammatory nature of these diseases. The paper presents the main clinical manifestations and laboratory markers that enable differential diagnosis between autoimmune and autoinflammatory heart diseases. Additionally, it provides an evidence-based approach to the effectiveness of various anti-inflammatory and immunosuppressive drugs in different types and stages of inflammatory diseases of the myocardium and pericardium.