bluuebunny/crossref_metadata_2025 huggingface dataset:
Clusterin mRNA silencing reduces cell proliferation, inhibits cell migration, and increases CCL5 expression in SW480, SW620, and Caco2 cells
Authors: Rui Fan , Abdalkareem Eshtiyag Abdalla , Huat Lim Boon , Yin Khoo Boon
Published: April 2022

Objectives

This study aimed to investigate the effects of specific gene silencing in colorectal cancer cells. Clusterin protein was found in the serum samples of colorectal cancer patients infected with Schistosoma mansoni previously.

Methods

For this reason, silencing clusterin mRNA in colorectal cancer cells was first performed to study the cytotoxic effect by lactate dehydrogenase assay. Next, propidium iodide staining and flow cytometry were performed to investigate the cell cycle profile in clusterin-silenced cells. A wound-healing assay was also used to examine the migration rate of clusterin-silenced cells. The mRNA expression of cell proliferation- and migration-related genes was then assessed by real-time PCR.

Results

Clusterin mRNA silencing caused a significant reduction in cell growth but induced no cell cycle arrest or potential apoptosis in all cells. It was found in this study that cell migration rate was inhibited in clusterin-silenced cells. Surprisingly, significantly induced chemokine (C–C motif) ligand 5 (CCL5) mRNA expression was detected in clusterin-silenced Caco2, which indicated that the cell proliferation and migration of clusterin-silenced Caco2 were likely associated with CCL5 mRNA expression.

Conclusions

Clusterin may be a potential target for regulation, staging, surveillance, and developing a cost-effective therapeutic agent for treating parasite-infected Caco2 type of colorectal cancer patients.
A Path to Passion
Authors: Robson Terri
Published: April 2022

In the Autistic world in which many of us live, very little is discussed about entrepreneurship. This can be done if one finds an interest one is passionate about. With the help of professionals, friends and family, a business can be set up and run successfully. This article discusses my journey to this goal, the trials worked through and endured, as well as the success I have achieved. It is my hope from this telling of my story that others get the inspiration to create a dream and follow it.
The Avdat in Late Antiquity Project: uncovering the Early Islamic phases of a Byzantine town in the Negev Highlands
Authors: Bucking Scott , Fuks Daniel , Dunseth Zachary C. , Schwimer Lior , Erickson-Gini Tali
Published: April 2022

Three seasons of archaeological fieldwork by the Avdat in Late Antiquity Project have yielded new evidence of intensive Early Islamic activity in the late antique town of Avdat in Israel's Negev Highlands. This evidence has important implications for understanding the fate of such towns in the region during the Byzantine–Islamic transition.
Deformation Failure Mode of Slope Based on Stochastic Limit Equilibration-Material Point Method for a Hospital Environment
Authors: Li Xing , Tian Jun
Published: April 2022

Slope instability is a dynamic evolution process involving large slope deformation, which often determines the consequences of landslide failure. In this paper, the stochastic limit equilibration-material point method is used to study the dynamic evolution process of different failure modes of slope under the condition that the slope parameters are not uniformly distributed in the space of a hospital environment. Based on this, in this article, the influencing factors of the study on slope deformation and failure mode according to deformation and destruction will be divided into sandstone slope deformation and destruction difference weathering, the unfavorable combination of bedding structure surface and cutting layer structure surface, artificial excavation disturbance, and the deformation characteristics of failure mode and all kinds of process will be analyzed. Finally, Phase2 software was used as a tool to study the stability and failure mode of the rock slope, and it was found that both side slope angle and rock strata dip angle would have an impact on the slope deformation and failure.
Kinetics, isotherm and thermodynamic studies on the adsorption of methylene blue dye by iron doped activated carbon
Authors:   Centre for Environmental Research, Department of Chemistry, Kongu Engineering College, Perundurai, Tamilnadu, India, Revathi A. , Palanisamy P. N. ,   Centre for Environmental Research, Department of Chemistry, Kongu Engineering College, Perundurai, Tamilnadu, India
Published: April 2022

The present study details the synthesis and characterisation of iron (Fe) doped activated carbon from Alstonia Scholaris (AS-Fe) natural wood waste. Investigation addresses the utilization of natural wood waste for useful and potential high temperature Alstonia Scholaris activated carbon (HT-AS). Iron doped activated carbon (AS-Fe) is used for the treatment of industrial waste water. Activated carbon and utilization performances are well attributed to the preparation methods and hence a range of characteristic interpretation like Fourier transform spectroscopy (FTIR), X-Ray powder diffraction, UV-Vis spectra, Field emission Scanning Electron Microscopes (FE-SEM) and EDAX analysis are evaluated. The result of AS-Fe is well distinguished by comparing the features with the porous high temperature Alstonia Scholaris activated carbon (HT-AS). High-performing iron doped activated carbon (AS-Fe) developed from natural wood waste reveals a distinct advantage in the adsorption approach for the removal of organics such as synthetic textile colours from industrial wastewater.
The authenticity of women who decided for a natural childbirth: experiences
Authors: Elias Elayne Arantes , Floriani Dayanne Teresinha Granetto Cardoso , Manhães Letycia Sardinha Peixoto , Paiva Andyara do Carmo Pinto Coelho , Cardoso Fabrício Bruno , Silva Lauanna Malafaia da , Mendes Nelson Augusto
Published: April 2022

Objective: to understand the meanings of experiences of women who have undergone natural childbirth. Methods: heideggerian qualitative phenomenological research with 14 women carried out through open audiorecorded interviews, transcribed and analyzed whose steps were the routing for constitution of units of meaning, understanding and hermeneutics. Results: most of them decided to give birth normally and this experience meant: having chosen and dreamed of natural birth because it was better, having planned to give birth, having known how the moment would be and that it was a great experience allied to the feeling of being more powerful and strong and that they would advise other women without any regrets. Despite the positive experience, many did not receive information about childbirth. Conclusion: the experience of natural birth proved to be authentic due to the women’s decision, with assertive reports, which is provided by quality assistance by obstetric nursing, active from prenatal to postpartum. Contributions to practice: reflection and strengthening of the obstetric nurse’s actions in this process, which goes from prenatal care to labor, childbirth, and puerperium, following the guidelines of good practice in women’s health care and public health policies.
Repercussions of the pandemic of COVID-19: care of the pediatric population in Primary Health Care
Authors: Shibukawa Bianca Machado Cruz , Uema Roberta Tognollo Borota , Piran Camila Moraes Garollo , Fonseca Beatriz Sousa da , Furtado Marcela Demitto , Merino Maria de Fátima Garcia Lopes , Higarashi Ieda Harumi
Published: April 2022

Objective: to describe the repercussions of the COVID-19 pandemic on the care of the pediatric population in Primary Health Care. Methods: qualitative study conducted with 28 primary care coordinators linked to a regional health region. Data were imported into the NVivo Release Program for content analysis. Results: there was a reduction of access to primary care for actions of prevention and promotion of child health, intensifying assistance based on the biomedical model to the detriment of surveillance of child development as well as the need for (re)organization of assistance through new strategies. Conclusion: the pandemic had a negative repercussion on child health care represented by the reduction in demand and pediatric demand in Primary Health Care, however, it was identified that services were reorganized through new appointments and tele-attendance to maintain the principles of primary care and the Brazilian Unified Health System. Contributions to practice: the study enabled the identification of new forms of health organization regarding the care of children in primary care in the context of the COVID-19 pandemic. Because, the use of telehealth can contribute to the monitoring of children in other realities.
Liburni and the Caput Adriae Region in the Early First Millenium BC – Discussing the Liburnian two-part bow Fibulae
Authors: Teržan Biba
Published: April 2022

The article examines two-part bow fibulae (of the Osor type, variant A, or II according to D. Glogović), which formed a part of female attire in the region of Liburnia during the 9th and 8th centuries BC. Given their bow shapes and long, decorated pins these fibulae can be related to the two-part bow fibulae with conical helices also of the Osor type. Therefore, it can be presumed that the two-part bow fibulae discussed here originally formed part of headdress decorations or elaborate hairstyles as well. Special attention is given to the presence of such fibulae at the site of Škocjan, both at the necropolis and within the hoard of Mušja jama. As the site in question is fairly distant from the main Liburnian region, the attested examples both of single-looped bow fibulae with two knobs and of two-part bow fibulae are interpreted in relation to Škocjan as a “sacredplace” of supra-regional importance.
Numizmatička svjedočanstva mongolske najezde na šire područje Splita iz ožujka 1242. godine
Authors: Ilkić Mato , Filipčić Dejan
Published: April 2022

U ovome članku autori reinterpretiraju već odavna poznate brojne srednjodalmatinske ostave s dominirajućim splitskim komunalnim novcem, povezujući njihovo skrivanje s ožujkom 1242. godine kada su Belu IV., hrvatsko-ugarskog kralja u bijegu prema Jadranu, progonili Mongoli. S njihovom najezdom mogu se dovesti u vezu i neki pojedinačni nalazi novca iz pećina u jugoistočnoj Lici i sjevernoj Dalmaciji za koje se pretpostavlja da su domaćemu stanovništvu mogle poslužiti kao privremeni zbjegovi.
The Role of Intestinal Microbiota and Its Recovery in COVID-19
Authors:   National University of Food Technologies, Starovoitova S. , Demchenko O. ,   Kyiv Perinatal Center, Bila V. ,   Kyiv Perinatal Center, Spivak M. ,   Zabolotny Institute of Microbiology and Virology, NAS of Ukraine
Published: April 2022

Today, during the SARS-CoV-2 pandemic, when there are no clear therapeutic strategies for prevention and treatment, attention should be paid to alternative treatments, which may include the use of bacteriotherapeutic drugs based on probiotic microorganisms, i.e. representatives of the host normobiota. Experimental data show that changes in immune balance in patients with SARS-CoV-2 may be mediated by corresponding changes in the host intestinal microbiota. This statement is especially significant for the elderly, whose intestinal biota is less diverse. Especially the number of useful representative’s decreases, which leads to greater sensitivity of the older generation to SARS-CoV-2. The composition and function of the intestinal microbiota may be a potential biological mechanism responsible for the diversity of susceptibility of different groups of people to SARS-CoV-2. A bidirectional connection along the intestinelung axis due to soluble microbial metabolites transported by the bloodstream is shown. The intestinal microbiota produces many diffusing metabolites with immunomodulatory properties. Given the potential beneficial effects of bacteriotherapeutic drugs and functional foods enriched with probiotic microbiota during respiratory viral infection, their use as therapeutic agents during SARS-CoV-2 infection can be considered. Since the microbiota can be maintained using adequate, safe, and relatively inexpensive bacteriotherapeutic drugs (pro-, pre-, para-, post-, synbiotics, immunobiotics, functional foods enriched with probiotic microorganisms, etc.), their use should be considered as adjunctive therapy to limit SARS-CoV-2 progression in infected patients or as a prophylactic strategy for uninfected people at risk during the expansion of SARS-CoV-2.
DNA Repair Enzymes as Therapeutic Agents: a Review
Authors:   Sanjivani Arts, Commerce and Science College, Dahikar S.B. , Bhutada S.A. ,   Sanjivani Arts, Commerce and Science College
Published: April 2022

DNA damage is long recognized factor for development and progression of cancer in humans. Genome instability is the leading factor behind development of cancer. There are some DNA repair pathways and DNA damage checkpoints present in all creatures, without them the functional stability gets compromised. Impaired DNA repair results in genomic instability leading to development of cancer, limited lifespan, early ageing. UV rays and Ionizing radiations are the major exogenous forces responsible for DNA damage, causing lesions in DNA. These lesions are cause of photoageing. Protection administered by conventional sunscreen is merely prophylactic if lesions have already occurred. There is an increasing demand for such product which can reverse or delay the effects of photoageing thus the protection offered by conventional sunscreen can be improved. This review focuses on recent developments on involvement of various DNA repair enzymes in treatment of cancer as well as in skincare products such as sunscreen.
The mediating effects of parent-child interaction in the relation between young children's playfulness and peer competence
Authors: Baek Ji-seong , Seo Hyun
Published: April 2022

Ji-seong Baek, Hyun Seo
A Quality Improvement Project to Reduce Time to Full Enteral Feeds for Very Low Birth Weight Neonates
Authors: Olowoyeye Abiola , Basile Eric , Kim Susan , Thompson-Branch Alecia
Published: April 2022

BACKGROUND

Adherence to standardized feeding guidelines has been proposed as a strategy to limit morbidity in very low birth weight neonates. Fostering adherence limits the variability in medicine that affects the quality of patient care. The aim of this study was to reduce by 20% the time to full enteral feeds in very low birth weight neonates in the NICU within a 12-month period.

METHODS

In a level IV regional perinatal center with low utilization of its feeding protocol, a 12-month quality improvement project was conducted with a key intervention of a feeding schedule calculator based on the unit standardized feeding protocol. Through studied education and implementation cycles, these feeding schedules were used to reduce time to full enteral feeds while monitoring adverse events related to their use.

RESULTS

During the course of this quality improvement project, our time to full enteral feeds of 160 ml/kg/day of feeds reduced from 24.7 days to 17.7 days after process changes with special-cause variation noted on control charts. We also showed a significant reduction in mean central line duration over the course of the project from a baseline of 19 days to 14.5 days.

CONCLUSION

Through a key intervention of a feeding volume calculator, we were able to reduce the time to full enteral feeds in neonates without any increase in adverse events of necrotizing enterocolitis or poor weight gain.
Екологічна економіка: інструмент реалізації концепції сталого розвитку
Authors: Dubovich Ion , Adamovsky Alexander , Vasylyshyn Khrystyna , Perkhach Oksana , Volkovska Yuliia , Petrețchi Nicolae-Miroslav
Published: April 2022

Серед основних проблем людства особливе місце належить охороні, використанню та відтворенню природних ресурсів, а також екологічному убезпеченню населення. Сьогодні ставлення більшої частини населення світу до природи має виразно споживацький характер, де природні ресурси та природні умови сприймаються лише як чинник, що впливає на розвиток економіки. Такий підхід населення до природи є хибним і призводить до погіршення стану природного життєвого довкілля, великомасштабних біологічних катастроф, а також погіршення якості життя та здоров’я людей.

Для об’єктивної оцінки обізнаності та ставлення населення до розвитку екологічної економіки і розуміння концепції сталого розвитку здійснено соціально-економічне дослідження, за результатами якого з’ясовано, що більшість громадян України (84%) вважають, що екологічна економіка є основним інструментом для реалізації сталого розвитку. Більшість респондентів (87%) вважають, що економічний розвиток має ґрунтуватись на теоретико-методологічній основі концепції сталого розвитку.

Встановлено концептуальні положення щодо вдосконалення розвитку економіки, орієнтовані на засадничі принципи екологічної економіки та моделі сталого розвитку. Обґрунтовано необхідність посилення ролі держави у розвитку екологічної економіки та практичній реалізації засад сталого розвитку, спрямованих на забезпечення належних контролюючих механізмів, невідворотності відповідальності за порушення законодавства та належної координаційної діяльності органів державної влади у сфері реалізації політики з питань сталого розвитку.

Запропоновано класифікацію та порівняльну характеристику еколого-економічних інструментів щодо реалізації сталого розвитку. Сформовано пропозиції щодо удосконалення шляхів запровадження інструментів екологічної економіки для реалізації концепції сталого розвитку
Оцінка кліматичних тенденцій в Українському Розточчі за результатами динаміки плювіотермічних умов
Authors: Stryamets Halyna , Prykladivska Tetyana , Hrebelna Valentyna , Skobalo Oksana , Ferents Natalia
Published: April 2022

Метеорологічними спостереженнями за період 2005-2020 рр. на метеостанції Природного заповідника «Розточчя» (49°55´N 23°45´E) встановлено загальні тенденції у динаміці головних кліматичних факторів – температури повітря і кількості опадів.

Аналіз місячних і сезонних параметрів опадів і температур повного шістнадцятирічного періоду показав, що сучасний клімат цієї території зазнав помітних змін порівняно з кліматом першої половини ХХ ст. (дані метеостанції Рава-Руська у північній частині Українського Розточчя – 50°14´N 23°37´E). Особливо відчутні зміни зафіксовано за останній п’ятирічний період 2016-2020 років.

Відбулось істотне підвищення температури, яка за весь досліджуваний період піднялась на 2,2°С, а за останні п’ять років – на 3,2°С. Суми літніх активних температур (більше 10°С) за період 2005-2020 рр. збільшились на 15%, за 2016-2020 рр.– на 18%, а у посушливі 2015, 2017, 2019 роки ці показники зросли на 27-36%.

За загального збільшення кількості опадів за досліджуваний період на 3,6%, відбувся несприятливий перерозподіл вологи по календарних сезонах року за рахунок зменшення її кількості у період вегетації і збільшення у холодну пору року. Якщо за архівними даними минулого століття літні опади становили 40% від річної кількості, то за період 2005-2020 рр. ця частка зменшилась до 33%, а за останнє п’ятиріччя – до 30%; відбулось не тільки зменшення літньої кількості дощів, але й зміщення їх піку з липня місяця на травень.

Гідротермічний коефіцієнт Г.Т. Селянінова за літні місяці 2005-2020 рр., порівняно з архівними даними, зменшився з 1,9 до 1,4; а по окремих літніх місяцях 2015, 2017 і 2019 років цей показник змінювався від мінімальних декадних значень у 0,01 до середніх місячних – від 0,1 до 0,9.

Наведені вперше для цієї території кліматичні діаграми наглядно демонструють динаміку плювіотермічних умов регіону, тобто зміни річного ходу кривих обох головних кліматичних факторів – опадів і температур. Кліматичні діаграми аномально сухих 2015, 2017 і 2019 років в Українському Розточчі нагадують середземноморський тип клімату зі значною зволоженістю перехідних сезонів і дефіцитом вологи в теплу пору року, коли літній максимум температур накладається на мінімум опадів. Виявлений дисбаланс у взаємозв’язку «температура – волога», особливо в останній п’ятирічний період, свідчить про дефіцит вологи, необхідної для розвитку рослин, і тенденцію трансформації клімату від м’якого гумідного до теплішого аридного
Властивості вживаної деревини як важливий чинник якості конструкційних матеріалів
Authors: Gayda Serhiy , Kiyko Orest
Published: April 2022

Встановлення основних показників вживаної деревини (ВЖД), зокрема основних шпилькових порід, є актуальною науковою проблемою, оскільки наповнення нормативної бази даних забезпечить виготовлення якісних виробів з деревини з максимальним урахуванням особливостей механічних і фізичних характеристик цього потенційного резерву сировини. ВЖД доцільно матеріально використовувати в технологіях деревооброблення для виробництва конструкційних матеріалів і складових елементів меблевих виробів. Визначено основні фізико-механічні властивості ВЖД низки деревних порід – ялиці, ялини, сосни, модрини, які широко використовують для отримання виробів у меблевій та деревообробній галузях за такими показниками: щільність, ударна і статична твердість, міцність при статичному згині, міцність при сколюванні та міцність при стиску вздовж волокон. Експериментально встановлено, що фізико-механічні властивості ВЖД зазначених порід нижчі від аналогічних показників з первинної деревини (ПД). Виявлено, що щільність зменшується не більше ніж на 4,7% (діапазон для різних порід – 1,54-4,67%); ударна твердість знижується в діапазоні 1,37-4,11%; статична твердість – зменшення для модрини становить 7,11%, для інших порід практично не перевищує 2,5%; міцність при статичному згині знижується в діапазоні 5,94-8,33%; міцність при сколюванні для трьох порід (окрім ялини) зменшується в діапазоні 3,23-7,23%, а для ялини вона зростає на 3,08%; міцність при стиску вдовж волокон знижується в діапазоні 1,72-8,89%. Результати досліджень показників фізико-механічних властивостей ВЖД основних шпилькових порід дали змогу зрозуміти динаміку цих показників порівняно з ПД, розробити практичні рекомендації щодо ефективного матеріального перероблення, наповнити нормативну базу даних, а набуті знання використовувати під час розроблення математичних моделей для прогнозування характеристик конструкційних деревинних матеріалів.
Antibacterial effects of biologically active ingredients in hop provide promising options to fight infections by pathogens including multi-drug resistant bacteria
Authors: Fahle Anton , Bereswill Stefan , Heimesaat Markus M.
Published: April 2022

Antibiotic resistance constitutes a global threat to the health care systems. The number of infections due to multidrug-resistant (MDR) bacteria increases progressively resulting in an estimated annual number of 750,000 fatal cases worldwide. Additionally, the lack of novel antibiotic compounds worsens the dilemma. Hence, there is an urgent need for alternative ways to fight antibiotic resistance. One option may be natural compounds with antibacterial properties such as hop and its biologically active ingredients which are used in traditional medicine since ancient times. This prompted us to perform an actual literature survey regarding the antibacterial properties of biologically active ingredients in hop including humulone, lupulone and xanthohumol. The 20 included studies revealed that lupulone and xanthohumol do in fact inhibit the growth of Gram-positive bacteria in vitro. In combination with distinct antibiotic compounds the hop ingredients can even exert synergistic effects resulting in enhanced antibiotic activities against defined Gram-positive and Gram-negative bacteria. In conclusion, biologically active ingredients in hop including lupulone and xanthohumol may be potential antibiotic compounds which either alone or in combination with other antibacterial substances open novel avenues in the combat of infections caused by pathogenic including MDR bacteria.
Oxidative and nitrosative stress in patients with meningitis
Authors:   Department of Nutrition and Dietetics, Faculty of Health Sciences, University of Gaziantep, Gaziantep, Turkey, Namiduru Emine Siber , Namiduru Mustafa ,   Department of Infectious Disease, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey, Karaoğlan İlkay ,   Department of Infectious Disease, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey, Koçak Kübra ,   Department of Infectious Disease, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey
Published: April 2022

Introduction and aim. Meningitis is an acute inflammation of the protective membranes covering the brain and spinal cord, known as the meninges. In this study, oxidative and nitrosative stress were evaluated in cerebrospinal fluid (CSF) and blood samples that were taken from patients with meningitis. Our goal was to identify a fast and a reliable biomarker using these parameters in order to the early diagnose of bacterial meningitis. Material and methods. In this study, 37 bacterial meningitis, 30 tuberculous meningitis and 30 viral meningitis cases were included. Serum/CSF total oxidant status (TAS) and total antioxidant status (TOS) were measured by the Erel method. Nitrotyrosine concentrations were quantified by using ELISA in both serum and CSF Results. Serum nitrotyrosine, CSF TAS and TOS levels were not significantly different in three groups (p>0.05). CSF nitrotyrosine levels were significantly higher in bacterial meningitis than tuberculous meningitis group (p<0.05). Viral meningitis patients had higher serum TOS and TAS concentrations than tuberculous meningitis group (p<0.05). Conclusion. As a result, we can say that the oxidative and nitrosative stress markers studied are not a rapid and reliable biomarker in bacterial meningitis’s diagnosis.
Breast hypertrophy, forward head posture, neck and shoulder pain-related disabilities and selected anthropometrics variables of female undergraduate students
Authors:   Department of Physiotherapy, College of Medicine, University of Lagos, Lagos, Nigeria, Akodu Ashiyat Kehinde , Oti Temiloluwa Grace ,   Department of Physiotherapy, College of Medicine, University of Lagos, Lagos, Nigeria, Lawal Abdulrazzaq Oluwagbemiga ,   Department of Surgery, College of Medicine, University of Lagos, Lagos, Nigeria
Published: April 2022

Introduction and aim. Large breast sizes frequently contribute to women presenting with severe pain symptoms. This study determined the association between breast hypertrophy, forward head posture (FHP), neck and shoulder pain related disabilities and selected anthropometric variables of female undergraduate students of College of Medicine, University of Lagos. Material and methods. A cross-sectional analytical study was conducted among 89 female undergraduate students (mean age = 21.45±1.29 years) with breast hypertrophy (cup size D and above). Breast cup sizes, neck and shoulder pain related disabilities, forward head posture were measured using a measuring tape, neck pain disability scale, shoulder pain disability index and craniovertebral angle (CVA) using photography method. Results. The prevalence of forward head posture among the participants was 43(48.3%). Twenty-eight (31.3%) participants had a “DD” cup size, twenty-six (29.2%) participants had a “DDD” cup size. Sixty-five (73%) of the participants had neck pain related disabilities and 10 (11.2%) of the participants had shoulder pain related disabilities. There was association among weight, forward head posture (p=0.027) and breast hypertrophy (p=0.016). Conclusion. Neck, shoulder pain related disabilities, and forward head posture is prevalent among undergraduates with breast hypertrophy and weight has an influence on forward posture and breast hypertrophy.
Nanomedicine – a review
Authors:   Department of Photomedicine and Physical Chemistry, Medical College of The University of Rzeszów, University of Rzeszów, Poland, Dynarowicz Klaudia , Aebisher David ,   Department of Photomedicine and Physical Chemistry, Medical College of The University of Rzeszów, University of Rzeszów, Poland
Published: April 2022

Introduction and aim. Nanomedicine is a discipline of technology and science, the potential of which has recently fascinated scientists in the fields of physics, biotechnology, chemistry and medicine. This department deals with everything on the nano scale, i.e. on the level of individual atoms and molecules. This work presents the nano scale, i.e. on the level of individual atoms and molecules. Nanotechnology is currently one of the most popular and dynamically developing fields, not only in electronics, but above all in pharmacy and medicine. Material and methods. In this article a narrative review regarding nanomedicine. Analysis of the literature. The desire to summarize information about nanomedicine application of singlet oxygen is presented. Nanotechnology is a discipline of technology and science, the potential of which has recently fascinated scientists in the fields of physics, biotechnology, chemistry and medicine. Conclusion. The use of nanostructures is currently very efficient. The areas in which the potential of nanoparticles is constantly researched and confirmed by numerous articles are: radio- and chemotherapy, cancer diagnostics and imaging medicine (MRI and fluorescence imaging).
Non-ketotic hyperglycemia and diabetic striatopathy – a rare presentation with hemichorea-hemiballismus
Authors:   Department of Radiology, University of Health Sciences Prof Dr Cemil Tascıoglu City Hospital, İstanbul, Turkey, Erok Berrin , Keklikoğlu Taha Oğuz ,   Department of Radiology, University of Health Sciences Prof Dr Cemil Tascıoglu City Hospital, İstanbul, Turkey, Kış Naciye ,   Department of Radiology, University of Health Sciences Prof Dr Cemil Tascıoglu City Hospital, İstanbul, Turkey, Önder Hakan ,   Department of Radiology, University of Health Sciences Prof Dr Cemil Tascıoglu City Hospital, İstanbul, Turkey
Published: April 2022

Introduction and aim. Non-ketotic hyperglycemia (NKHG), also known as hyperosmolar hyperglycemic state (HHS) is a serious metabolic complication of diabetes mellitus (DM).The mortality rate can be up to 20% and this is much more higher than that of diabetic ketoacidosis (DKA). It is usually precipitated by an event such as pulmonary/urinary infection, myocardial infarction (MI) or stroke. In this state of metabolic derangements, central nervous system (CNS) manifestations including altered mental status with or without focal neurological deficits are prominent clinical presentations. On the other hand, HHS may also be complicated with various other CNS events. Herein, a quite rare presentation of HHS with hemichorea ‒ hemiballismus in a 71 year old female patient with type 2 DM is presented. Description of the case. A 71-year-old female patient type 2 DM presented to our emergency department with progressive involuntary movements on the right upper and lower extremities accompanied by semiconsciousness during the last 24 hours. On neurological examination, cranial nerves and cerebellar signs were found to be normal, as the deep tendon reflexes. However, involuntary non-rhythmic writhing movements at rest were present on her right sided extremities. The fingerstick evaluation showed marked hyperglycemia (HG). The laboratory findings were characterized with high blood glucose level without obvious acidosis compatible with HHS. In urine analysis, glucosuria without significant ketonuria was detected. On head CT, subtle hyperdensity was noted in the left neostriatal regions without any mass effect or perilesional edema, compatible with left sided diabetic striatopathy (DS). Conclusion. Diabetic striatopathy is a quite rare presentation of HHS with hemichorea – hemiballismus. The characteristic computed tomograhy (CT) findings of associated striatopathy should be differentiated from vascular lesions that may also present with unilateral findings in the course of HHS and should not be overlooked in diabetic patients to recognise the ongoing HHS before the coma precedes.
Contribution of diffusion weighted MRI to the differential diagnosis of renal masses
Authors:   Department of Radiology, University of Medical Sciences, Prof Dr Cemil Tascıoglu City Hospital, İstanbul, Turkey, Kış Naciye , Düzkalır Hanife Gülden ,   Department of Radiology, University of Medical Sciences, Kartal Education and Research Hospital, İstanbul, Turkey, Ağaçlı Mehmet Oğuzhan ,   Department of Radiology, University of Medical Sciences, Umraniye Education and Research Hospital, İstanbul, Turkey, Erok Berrin ,   Department of Radiology, University of Medical Sciences, Prof Dr Cemil Tascıoglu City Hospital, İstanbul, Turkey, Kılıçoğlu Zeynep Gamze ,   Department of Radiology, University of Medical Sciences, Haydarpaşa Education and Research Hospital, İstanbul, Turkey
Published: April 2022

ntroduction and aim. We aimed to assess the usefulness of diffusion weighted imaging (DWI) and apparent diffusion coefficients (ADCs) for characterizing renal masses. Material and method. In this retrospective study we measured the ADC values of renal masses at b=0, b=500 and b=1000. Measurements were made by placing a circular region of interest with a diameter of 1 cm.ADC values from normal renal parenchyma were taken to define the ADC and to compare with the ADC values of the lesions. Results. A total of 72 lesions of 54 patients were included.40 of the masses were benign and 32 were malignant. The ADC values of benign lesions at both b values were significantly higher than malignant lesions. We found the lowest values in angiomyolipomas (AMLs) and oncocytomas and the highest values in Bosniac type I cysts. Similarities was found between the ADC values of some AMLs and the RCCs. In terms of statistical results, the inclusion of AMLs in the analysis did not significantly affect the difference between malignant and benign lesions. Conclusion. In our study, the ADC values of benign renal masses were higher than those of normal renal parenchyme, which is higher than those of malignant renal masses.The lowest ADC values were observed in AMLs and oncocytomas.
Topical lidocaine anesthesia for nasopharyngeal sampling – a double-blind randomized placebo-controlled trial
Authors:   Department of Emergency Medicine, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey, Tekyol Davut , Akbas Ilker ,   Department of Emergency Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey, Dogruyol Sinem ,   Department of Emergency Medicine, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey, Kocak Abdullah Osman ,   Department of Emergency Medicine, Faculty of Medicine, Ataturk University, Erzurum, Turkey, Çakır Zeynep ,   Department of Emergency Medicine, Faculty of Medicine, Ataturk University, Erzurum, Turkey
Published: April 2022

Introduction and aim. The aim of this study is to evaluate the effects of topical lidocaine application for nasopharyngeal sampling, on pain perception, the comfort of the patients, and the application difficulty for healthcare staff. Material and methods. This study conducted with 100 healthy volunteers (50 participants in Lidocaine group and 50 participants in Placebo group). Two ml of a solution containing 10 mg/ml of lidocaine was applied to each nostril of the participants in the Lidocaine group, and the same dose of 0.9% NaCl to the Placebo group. We compared the changes in pain intensity and discomfort intensity using two numerical rating scales, the frequency of undesirable reactions, and the judgment of the practitioner staff. Results. There were statistically significant decreases in pain and discomfort scores in the Lidocaine group. Similarly, there were statistically significant decreases in the frequency of all undesirable reactions except “grimace”, in the second sampling in the Lidocaine group, however, there was a statistically significant decrease only in “holding staff’s hand” in second sampling in the Placebo group. Conclusion. Intranasal lidocaine application reduces the pain that occurs during nasopharyngeal sampling and makes the procedure easier for the patient and the healthcare worker.
Muscle energy technique and static stretching in patients with mechanical neck pain – a randomized study
Authors:   Department of Medical Rehabilitation, Faculty of Basic Medical Sciences, College of Health Sciences, Obafemi Awolowo University, Ile Ife, Nigeria, Ojoawo Adesola Ojo , Ige Blessing ,   Department of Medical Rehabilitation, Faculty of Basic Medical Sciences, College of Health Sciences, Obafemi Awolowo University, Ile Ife, Nigeria, Kunnuji Kanode ,   Department of Physiotherapy, Obafemi Awolowo University Teaching Hospitals Complex, Ile Ife Nigeria
Published: April 2022

Introduction and aim. Neck pain is becoming increasingly common throughout the world with a considerable impact on individuals. This study compared the effects of muscle energy techniques (MET) and static stretching (SS) on pain intensity and functional disability of patient with mechanical neck pain. Material and methods. Fifty subjects with mechanical neck pain recruited were randomly allocated into MET and SS groups equally. Subjects in MET received MET protocol, and SS groups were treated with SS; both groups had treatment twice a week for six weeks. Pain intensity and functional disability at baseline, 3rd and 6th week of treatment were measured. Descriptive and Inferential statistics were used to analyze the data. Alpha level was set at <0.05. Results. There were 12 males and 13 females for MET with age ranged between 31–53 years mean was 42.41± 7.35 years and 11 males and 14 females in SS group with age range 22–60 years and mean age of 42.91±10.44 years. There was a significant reduction in pain intensity and disability in MET’s and SS group (p<0.05) when pre-treatment, 3rd week and 6th week treatment were compared. Pain intensity was lower at SS than MET while functional disability was lower in MET than SS p<0.05 at 6th week Conclusion. MET reduces ND more than SS and SS reduces pain intensity better MET.
British Crop Production Council (BCPC) Virtual Diseases Review (October 2021): Exploring Alternatives to Enhance Plant Health
Authors: Lucas John A.
Published: April 2022

This online conference opened with a particular instruction to delegates – arrive with an open mind. No doubt this arose from the common perception that biological alternatives to synthetic pesticides are a less reliable and hence more risky means of crop protection. In her Introduction
the Chairperson Kate Storer (ADAS) emphasized the need for, and growing interest in, alternative approaches to plant health, given the current challenges facing agriculture. While definitions of plant health vary there is a consensus that the genetic potential of crops cannot be realized by
a single means, and a more holistic concept is required if we are to achieve sustainable production systems with a lower carbon footprint. The yield of some crops such as wheat have plateaued in recent years, and there is evidence for higher annual variability in yield, in spite of the usual
inputs of fertilizers and fungicides. This may be a result of a more volatile climate, as well as the erosion of efficacy of some crop protection chemicals due to the development of resistance in target pests, weeds and pathogens. Increasing the resilience of crops is now a high priority.
There is a renewed focus on the plant-microbial interactions influencing crop performance, from the well-known mutualistic associations such as mycorrhizas, to the complex communities of microbes colonizing plant surfaces and tissues (the microbiome). These have a range of potential effects
on plant health, including improved nutrition, inhibition of pathogens, and priming plant defence. Optimizing these associations is one aim of current research, and they may also be a potentially rich source of biologically active metabolites. Understanding the impact of management practices,
such as ploughing and crop rotations, on beneficial interactions is also important to maximize their benefits.
Maize grain supply and demand for the animal protein chain in the Rio Grande do Sul State, Brazil
Authors: Camargo Flávio Anastácio de Oliveira , Battisti Rafael , Dalchiavon Flávio Carlos
Published: April 2022

ABSTRACT: The animal production system has been affected in the Rio Grande do Sul State by low maize production, mainly non-ruminants. The total demand is not well known and official data are inaccurate and underestimated. This research characterized and analyzed the maize grain demand and supply for animal feed in the last 15 years at the Rio Grande do Sul State. The state supply was obtained from governmental harvests measurement. The demand was obtained by the total animals (swine, poultry and dairy and beef cattle), while the total state demand was obtained using the relative national consumption from these segments in relation to the total. The current maize grain demand was at the order of 6 million tons for the feeding of swine, poultry and cattle, while total demand was between 9 to 12 million tons in the Rio Grande do Sul State. The state maize production supplied near half of the total demand for the animal protein chain, characterizing a significant deficit for this sector, providing instability and making this productive chain economically unfeasible in the state.
Prothrombin time and activated partial thromboplastin time reference intervals in dogs, by gender and age group using the Start®4 (Stago)
Authors: Barbosa Marta , Pires Maria João , Queiroga Felisbina , Pires Carlos André , Dinis Tânia , Silvestre-Ferreira Ana C.
Published: April 2022

ABSTRACT: Prothrombin time (PT) and the activated partial thromboplastin time (aPTT) are useful tools for the diagnosis and monitoring of coagulation disorders in Veterinary Medicine. Our objectives were: to establish reference intervals (RI) for PT and a PTT for the dog using the Start®4 (Stago), to compare the obtained RI with literature; to evaluate the effects of gender and age on the coagulation profile. Plasma samples of 122 healthy dogs (57 males; 65 females) aged between 4 months and 18 years, divided into three age groups (0-2 years old; 3-10 years old; > 10 years old) and grouped in to males and females were analysed. The RI were estimated following the ASVCP guidelines with the Reference Value Advisor software. The RI were: PT 6.7’’ to 10.8’’; aPTT 9.0’’ to 14.8’’. PT was significantly higher in females than in males. Dogs aged 10 years or older have significantly higher mean aPTT times than younger dogs. RI comparison showed a considerable percentage of cases outside the reference RI of the literature (PT - 79.3%; aPTT - 77.1%), demonstrating the need of each laboratory to calculate its own RI. The RI established in this study are applicable for the coagulation profile assessment in dogs.
COMBINING DIFFERENT CONCURRENT TRAINING METHODS IN OLDER ADULTS WITH METABOLIC SYNDROME
Authors: Da Silva Marco Antônio R. , França Elias de , Baptista Liliana C. , Neves Rafael S. , Loureiro Helena , Caperuto Erico C. , Veríssimo Manuel T. , Martins Raul A.
Published: April 2022

ABSTRACT Introduction: There are no studies comparing the effects of different concurrent training routines [i.e., a resistance training plus high-intensity interval training (RT+HIIT) program compared to an RT plus moderate-intensity continuous training (RT+MICT) program] on cardiorespiratory fitness (CRF) and physical performance in older adults with metabolic syndrome (MetS). Objective: This study aimed to compare the effects of two concurrent training routines, RT+HIIT versus RT+MICT, on CRF and physical fitness in adults and older adults with MetS. Methods: Thirty-nine participants (67.0±6.7 years of age) were randomly assigned into three groups: RT+ MICT, RT+ HIIT and the control group (CON, no exercise). The 12-week physical training program consisted of 3 sessions/week (~50 minutes/session). The aerobic training component was customized for iso-caloric energy expenditure (P≥0.217) and iso-load distribution (TRIMP, P≥0.893), however the MICT component had a longer aerobic training time (P≤0.01). We evaluated pre- and post-evaluation CRF (VO2peak), physical capacity [power of lower limbs (PLL), running velocity, and running time to exhaustion], plasma lactate, rate of perceived exertion (RPE), resting heart rate (HRrest), and peak heart rate (HRpeak). Results: At the end of the intervention, a significant increase in the VO2peak was observed only in the RT+HIIT group (P=0.01), but compared to the CON group both RT+HIIT and RT+MICT groups had significant improvement in the VO2peak (P≤0.02). Only the RT+HIIT group had lower HRrest as compared to the baseline and the CON group. Also, both RT+HIIT and RT+MICT groups, but not CON, significantly improved running speed, time to exhaustion, and PLL (P<0.05). There were no significant changes in HRpeak, RPE, and lactate for any of the groups. Conclusion: Our results suggest that 12 weeks of RT+MICT or RT+HIIT improve lower-limb physical performance. Also, our results suggest that RT+HIIT provides additional CRF benefits in older adults with MetS. Level of evidence II; Randomized Experimental Study.
Espalhamento elétron-pósitron
Authors: Landim Erick Otavio Aquino , Rodrigues Armando Flavio
Published: April 2022

Este trabalho tem como foco estudar o espalhamento elétron-pósitron. Utilizando os o postulados da mecânica quântica, teoria de espalhamento e funções de Green, é mostrada a forma da matriz-S e sua relação com seções de choque. Além disso, são apresentadas algumas regras de Feynman que são utilizadas para encontrar a seção de choque de um espalhamento elétron pósitron resultando em um par múon-antimúon e a seção de choque referente ao mesmo espalhamento, porém gerando dois fótons. A técnica também é utilizada para escrever as seções de choque de processos de produção do bóson de Higgs através de um espalhamento elétron pósitron, o Higgs-strahlung e a fusão WW. É apresentado então um breve texto sobre os programas ILC e CLIC e sua relação com uma nova física.
Effectiveness of an educational video in older adults’ perception about falling risks: a randomized clinical trial
Authors: Sá Guilherme Guarino de Moura , Santos Ana Maria Ribeiro dos , Carvalho Khelyane Mesquita de , Galindo Neto Nelson Miguel , Gouveia Márcia Teles de Oliveira , Andrade Elaine Maria Leite Rangel
Published: April 2022

ABSTRACT Objective: to assess the effectiveness of using an educational video in comparison with verbal nursing guidelines in increasing older adults’ perception of falling risks. Method: this is a randomized clinical trial in a cluster, with 138 community older adults, randomized into an intervention group, which watched an educational video, and a control group, which received verbal instructions. The perception of falling risks was assessed by FRAQ-Brazil in the pre-test and after a 30-day follow-up. Student’s t-test was used for dependent samples to compare intragroup means and for independent samples to compare intergroup means. The effect size was determined by Cohen’s d. Results: in the intragroup analysis, intervention and control groups had an increase in perception, with a statistically significant difference between pre-and post-tests. In the intergroup analysis, the control group showed a greater increase in the perception of falling risks in relation to the intervention group (p = 0.013), with Cohen’s d of small effect. Conclusion: the use of an educational video and verbal instructions increased older adults’ perception of falling risks, with better results in the control group. However, the effect size was small. RBR-8nfggd.