bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness of Gamification of Ubiquitous-based Learning Media as an Initiative of Open-World Learning Metaverse Conversion in Business and Management Course
Authors: Hadi Wira Prabowo Suryo , Murdiono Achmad , Murdiono Achmad , Aulia Martha Jefry , Zutiasari Ika , Abd Aziz Norzalita
Published: January 2024

The low-education index also causes the low level of Indonesia’s competitiveness in the ASEAN Region in Indonesia. A strategy to improve the quality of education in Indonesia is needed. One of these strategies is technology-based learning media innovation. This is known because of the inability of existing learning media to meet the learning needs of students in conditions of swift technological development. So, it is necessary to increase the effectiveness of learning with the technology-based, problem-based learning (PBL) method. One of the efforts that can be made is the gamification of ubiquitous-based learning media. This can also be an open-world learning metaverse conversion initiative in the world of education. The approach used in this study is a quantitative approach, which is significant in the effectiveness of the use of gamification of ubiquitous-based learning media applications on students’ interest in learning and mastery of the material. This study involved 100 application users, in this case, university students, who took business and management courses at various universities in East Java. The results of this study indicate that students have an interest in learning by participating in business and management courses and are able to improve material mastery when using gamification applications from ubiquitous-based learning media. From the results of this study, it is hoped that the application of gamification of ubiquitous-based learning media can be an alternative media learning for business and management courses and can be an open-world learning metaverse conversion initiative in the world of education.
Keywords: business and management course, gamification, learning media, projectbased learning, ubiquitous learning
Metodología integral del diseño interior de casa habitación, hacía el bienestar del ser humano
Authors: NARANJO MERINO LILIANA
Published: January 2024

De los espacios que habita el ser humano, la casa habitación constituye un espacio de conexiones físicas y emocionales fundamentales para su desarrollo, y el diseño de interiores es el medio por el cual comprende el espacio e influye en su comportamiento, por tanto, el diseñador debe crear espacios que generen un impacto positivo en el ser humano, sin embargo, no hay una metodología con base científica que parta del usuario para la generación de bienestar. Por tanto, el objetivo de esta investigación es proponer una metodología, partiendo de un análisis comparativo entre análogas del diseño industrial y la arquitectura, para así presentar una metodología de diseño interior integral. Esta es una metodología holística que da un sustento científico al diseñador, para crear espacios en función del bienestar del ser humano.

PALABRAS CLAVE: metodología de diseño, diseño interior de casa habitación, diseño para el bienestar, diseño para ser humano.
«Allende el blanco plano de la música»: Mark Rothko y Samuel Beckett en la música de Rebecca Saunders
Authors: GONZALO CARBÓ ANTONI
Published: January 2024

No es casualidad que sean los mundos de Mark Rothko y Samuel Beckett los que inspiren el universo sonoro de la compositora Rebecca Saunders (Londres, 1967): una nada última o vacío religa la obra de los tres creadores. Tanto en la creación literaria (Mallarmé, Beckett, Celan), donde se produce la disolución de la escritura y del hablante mismo, como en la composición musical (Boulez, Sciarrino, Saunders), donde el sonido se desvanece hasta su completa reintegración en el silencio originario, la blancura es una imagen recurrente para designar la Realidad última. Esta albura omnipresente, es la geografía del proceso de autodisolución del individuo en la blancura omnímoda de lo absoluto. Saunders reitera la importancia que en la composición contemporánea tiene el silencio como lienzo sobre el que los sonidos se disuelven, alcanzando tan bellos colores, texturas y grados de presencia en su camino hacia la nada: «mancha [blanca] en el silencio».

PALABRAS CLAVE: Rebecca Saunders, Mark Rothko, Samuel Beckett, nada, vacío.
Habitar las Azoteas
Authors: PALLARÉS TORRES M. EUGENIA , PALLARÉS TORRES MIRTHA , CHANG LOU JING
Published: January 2024

Los procesos de densificación destinados a una mejor y mayor ocupación de los centros urbanos han provocado cambios significativos en la morfología de las ciudades, elevando las alturas, generando islas de calor, sombras y tensiones sobre el suelo, obligando a buscar nuevas oportunidades espaciales que permitan acoger las necesidades de las comunidades que habitan los edificios, escenario que facilitó la reinstalación de las azoteas como superficies factibles de habilitar para el uso social, superando los destinos técnicos y de servicio a los que se las había relegado y aprovechando los atributos espaciales que las caracterizan y que les permiten ofrecer una ubicación desde la que es posible reconocer el entorno y observar el paisaje, ampliando el campo visual y aportando con un lugar de privilegio para el desarrollo de experiencias comunitarias que validan la vida ciudadana y facilitan la cohesión social desde prácticas compartidas.

PALABRAS CLAVE: Azoteas, azotea viva, azotea activa, cubierta habitable, áreas comunes.
Símbolos de la resistencia: Sostenibilidad, empleabilidad, creatividad, emprendimiento
Authors: SAINZ GIL ANA MARÍA
Published: January 2024

Con este trabajo mostramos como el aprendizaje a través de la inserción curricular de los ODS 8, 4 y 17, en el Grado de Creación y Diseño en su etapa final, en 3º y 4º cursos, permite desarrollar en el alumnado la sostenibilidad y su conexión con la Agenda 2030; la empleabilidad a través del progreso de las competencias transversales complejas (ODS 4) de la UPV/EHU, así como las competencias transversales para la empleabilidad según la Comisión Europea; la creatividad, diseñando proyectos de empresa ad hoc basados en un cliente-a/usuario-a real y posteriormente creando su identidad y experiencia de Marca, para iniciar el marketing (ODS 8); y el emprendimiento, a través de la transferencia real del proyecto a la sociedad, a través de diversas convocatorias (ODS 17). Mostraremos el proyecto de empresa Ekko realizado dentro de la asignatura “Profesionalización y Gestión”, de 4º curso, como ejemplo de proactividad y resiliencia.

PALABRAS CLAVE: Sostenibilidad, empleabilidad, creatividad, emprendimiento, competencias transversales complejas
Desafiar el campo epistémico: academias móviles y prácticas artísticas en el siglo XXI
Authors: RENDA FRANCESCA
Published: January 2024

El siguiente artículo analiza dos proyectos a largo plazo - Silent University y Para-site School - que pueden adscribirse al ámbito del arte socialmente comprometido. Los proyectos descritos utilizan la educación como material de investigación, pero también como metodología y herramienta aplicable en la sociedad. Siguiendo la estela del giro educativo del arte, ambos proyectos se describen en relación con el contexto en el que se activaron y sus objetivos. Silent University, puesto en marcha por primera vez en Londres en 2012, fue creado por Ahmet Öğüt, con el objetivo de ofrecer un nuevo espacio educativo a los extranjeros residentes en la capital inglesa; Para-site School, concebido por Felipe Castelblanco en 2012 en Pittsburgh, nació de la necesidad de remediar las carencias institucionales de la universidad estadounidense y desde entonces se ha expandido a otras ciudades americanas y europeas. Ambos proyectos, que podemos denominar academias móviles, inician un proceso de análisis crítico de los sistemas educativos occidentales, evidenciando puntos de falibilidad y activando nuevas plataformas de co-aprendizaje.

PALABRAS CLAVE: arte socialmente comprometido, giro educativo, educación decolonial, academia móvil, educación participativa
Modelo de Proceso Creativo Dinámico por Actualización. Un campo fértil para desarrollar metodologías de creación artística y colaborar con la pedagogía de las artes
Authors: FORSTER SERGIO
Published: January 2024

La creatividad es una capacidad ampliamente valorada en todos los ámbitos de la actividad humana, especialmente en las artes. Existe un deseo generalizado de disponer de metodologías que fomenten, colaboren y provoquen la capacidad de producir de forma creativa, así como transmitir esta capacidad a otros.El objetivo del trabajo es presentar y proponer un modelo de proceso creativo centrado en los procedimientos que ocurren en el espacio temporal en el que se desarrolla. Se busca representar y conceptualizar gráficamente algunos aspectos teóricos y operativos del proceso para reconocer sus particularidades, componentes, relaciones, etapas y pasos de una producción deliberada que contribuyan a producir en lo desconocido. Esta representación nos permitirá ser conscientes de acciones y procesos que suelen ser invisibles y nos proporcionará herramientas para facilitar la creación artística, colaborar en procesos en desarrollo, construir metodologías y transmitir la capacidad de ser creativos.

PALABRAS CLAVE: Creatividad, proceso, modelo, arte, pedagogía.
CULTURA DIGITAL Y TECNODOCENCIA
Authors: Corrêa Thiago Henrique Barnabé , Lima Luciana de , Miranda Patiño Erick Omar , Loureiro Robson Carlos , Torres Merchan Nidia Yaneth , Borges Fiuza Ana Cristina
Published: January 2024

La pandemia (COVID-19) requirió que el mundo se reinventara. En las escuelas la figura del docente, posibilitó replantear acciones, desarrollando, en el sentido atribuído por Michel de Certeau, tácticas y estrategias para sobrellevar las nuevas dinámicas cotidianas de la virtualidad. En ese sentido, este artículo busca promover una reflexión desde diálogos de los autores sobre las implicaciones de  las tecnologías en la educación, con el fin de acercar, a la luz de diferentes teóricos, los conceptos metafóricos de la tecnología en el proceso de enseñanza-aprendizaje, y en la relación hombre-conocimiento. Además, se explica el significado atribuido a la tecnología en la docencia, con mirada crítica, a partir de una visión más amplia de sus posibilidades pedagógicas.
Oficina de elaboração de itens
Authors: Franklin Sue Ellen Guimarães dos Santos , Nobre Lopes Denise Andrea , Xavier Marcele Mara Alves
Published: January 2024

Esse artigo tem como objetivo descrever a experiência de uma oficina de elaboração de itens aplicada em uma turma de 9º ano de uma escola da rede pública municipal do EUSÉBIO-CE. Com base no trabalho com os descritores da Língua Portuguesa presentes na matriz de referência do Saeb e Spaece observamos o desenvolvimento dos alunos quanto ao nível de proficiência e aprendizagem significativa, no processo de construção do conhecimento. Utilizamos como fundamentação teórica os conceitos de avaliação da aprendizagem (LUCKESI, 1997) no contexto das avaliações externas e do planejamento do professor (FÁVERO; TONIETO, 2010), o conceito de letramento (SOARES, 2004) e dos gêneros do discurso (BAKHTIN, 1997). A oficina foi aplicada durante um mês, distribuído em encontros semanais totalizando quatro dias de execução. Apresentamos o passo a passo da oficina e a importância dessa metodologia para o desenvolvimento dos alunos, destacando sua formação e tornando-o capaz de intervir e construir o próprio conhecimento com responsabilidade e comprometimento.
Development and Validation of new RP-HPLC Method for the Simultaneous Estimation of Elbasvir and Grazoprevir in Combined Pharmaceutical Dosage Form
Authors:   Hindu College of Pharmacy, Amaravathi Road, Guntur, Andra Pradesh, 522002, India, Seetharamaiah P , Pappula Nagaraju , Poornima G , Chandanashree G
Published: January 2024

A reliable and exact technique was formulated for concurrently determining Elbasvir and Grazoprevir in tablet dosage forms. Chromatogram was developed by running a sample through Zodiac C18 column (4.6 x 150 mm, 5 µm) with the mobile phase containing Orthophosphoric acid (0.1%) and Acetonitrile in the ratio 50:50 v/v. The solution was pumped through the column at a flow rate of 1 ml/min, while maintaining the column temperature at 30°C. The optimized wavelength selected was 260 nm. The retention times for Elbasvir and Grazoprevir were determined to be 2.32 min and 3.30 min, respectively. The percentage recovery was found to be 100.16% for Elbasvir and 99.49% for Grazoprevir. The LOD and LOQ values obtained from the regression equations for Elbasvir were 0.30 mg/ml and 0.92 mg/ml, and for Grazoprevir were 0.28 mg/ml and 0.86 mg/ml, respectively. The regression equation for Elbasvir was found to be y = 2282.5x + 2407.2, and for Grazoprevir, it was y = 2366.5x + 7740.4. In conclusion, the developed method proved to be simple and economical, demonstrating successful application for the simultaneous estimation of both Elbasvir and Grazoprevir in bulk and combined tablet formulations. Keywords: Elbasvir, Grazoprevir, RP­HPLC, Validation, Simultaneous estimation
Revolutionizing Drug Design with Artificial Intelligence: A Comprehensive Review of Techniques, Applications, and Case Studies
Authors:   P G resident, Department of Pharmacology, RUHS-CMS, Jaipur, Rajasthan, India, Pareek Varun , Tuteja Lakshya , Sharma Lokendra , Kumar Susheel , Verma Noopur
Published: January 2024

Introduction: Artificial intelligence (AI) has the potential to revolutionize drug design and discovery by significantly reducing the time and costs involved in developing new drugs. This literature review aims to explore the use of AI in drug design, focusing on virtual screening, de novo drug design, and prediction of ADME properties. Objective: The objective of this review is to provide an overview of the AI techniques used in drug design and their applications in virtual screening, de novo drug design, and prediction of ADME properties. The review also aims to summarize the advantages and limitations of these approaches and present case studies and examples showcasing their use in drug design. Methodology: A comprehensive search of academic databases was conducted, and 11 relevant articles were selected for inclusion in this review. The selected articles were analyzed to identify the AI techniques used in drug design, their applications, advantages, and limitations. Case studies and examples were also examined to demonstrate the efficacy of AI in drug design. Results: AI techniques such as machine learning, deep learning, and reinforcement learning have been successfully used in virtual screening, de novo drug design, and prediction of ADME properties. Virtual screening involves the use of AI algorithms to identify promising compounds for further testing, while de novo drug design involves the generation of novel compounds using AI techniques. Prediction of ADME properties involves the use of AI to predict the absorption, distribution, metabolism, and excretion of drug candidates. The case studies and examples presented in this review demonstrate the potential of AI to accelerate drug design and discovery. Conclusion: AI has the potential to revolutionize drug design and discovery by significantly reducing the time and costs involved in developing new drugs. Virtual screening, de novo drug design, and prediction of ADME properties are among the most promising applications of AI in drug design. However, further research is needed to fully explore the potential of AI in drug design and overcome some of the limitations of current approaches. Keywords: Artificial Intelligence; Drug Design; Virtual Screening; De Novo Drug Design; ADME Prediction
A Review on Kidney Stones & A Patient Satisfaction Survey of an Ayurvedic Brand to Treat Kidney Stones
Authors:   Department of Pharmaceutical Chemistry, Rajmata Jijau Shikshan Prasarak Mandal’s College of Pharmacy, Maharashtra, India, Jain Kishor , Kachare Dhanshri , Gaikwad Rajnigandha , Kalje Mansi , Kantule Manjusha , Mohite Sudeshana , Rodage Nikita , Kandekar Vikas , Thikekar Archana
Published: January 2024

Objective: Kidney stones or nephrolithiasis, is a common problem worldwide. About 12% of the Indian population is estimated to have kidney stones and out of which 50% may end up with loss of kidney functions. In the first part of this article the pathophysiology of kidney stone, its types, risk factors, signs, symptoms, diagnosis and therapy have been discussed. Furthermore, various therapeutic approaches for kidney stone management are also briefly renewed. Methods: The second part of this article discusses a herbal formulation Ren-Cit® successfully used to treat kidney stone, its usage, composition as well as the actions of each of its medicinal constituents. A survey of patients who used Ren-Cit® has been conducted. Finding: The analysis of this survey revealed that 98% of the patients were suffering from kidney stone. Out of these 78% of the patients had hypertension and diabetes. None of the participants observed any side effects from the usage of Ren-Cit®. A total of 76% patients got relief from kidney stone by using Ren-Cit®. Various types of kidney stones diagnosed in these patients had varied composition, viz.; calcium oxalate stone (52%), calcium phosphate stone (16%), uric acid stone (12%), struvite stone (12%) and cystine stone (8%). Novelty: Ren- Cit® ayurvedic formulation proved to be effective on a wide range and types of kidney Stones. Keywords: Kidney Stone; Urolithiasis; Calcium Oxalate; Uric Acid Stone; Calcium Phosphate; Ren-Cit®
Cross-Cultural Learning and Adaptation: Enhancing Madrasah Management in Afghanistan through Insights from Indonesian Madrasah
Authors: Rizapoor Habiburrahman , Zafari Mohammad Anwar
Published: January 2024

This article explores the applicability of management practices from Indonesian Madrasahs to enhance Madrasah institutions in Afghanistan. Through a comparative analysis of current management strategies in Indonesian Islamic schools, renowned for their strong tradition of Islamic education and modern management practices, the study identifies adaptable strategies for integration into Afghan Madrasah management. The research delves into organizational structures, teaching methods, and administrative frameworks in both Afghan and Indonesian Madrasahs, aiming to establish an empirical understanding of current management practices in Afghan Madrasahs. The article highlights challenges and areas for improvement in Afghan Madrasahs while presenting evidence-based recommendations for incorporating successful Indonesian management techniques. Despite contextual differences, the research acknowledges the impact of cultural and social factors on the implementation of management strategies. The findings contribute to the enhancement of Madrasah education in Afghanistan, human resource development, and cross-cultural collaboration in Islamic education management.
Navigating Livelihood Challenges: A Comprehensive Analysis of the Socioeconomic Landscape in Rural Bangladesh during COVID-19 and post-COVID Era
Authors: Akter Akhy Asma , Roy Mallika
Published: January 2024

The worldwide emergence of the COVID-19 pandemic has not only exposed vulnerabilities in healthcare systems but has also laid bare the stark disparities within societies. Among those disproportionately affected are the marginalized and vulnerable populations, who face unique challenges in the wake of this unprecedented health crisis. In the context of Bangladesh, a country with diverse communities and economic strata, the effects of COVID-19 on marginalized people have been profound, encompassing health, economic, educational, and social dimensions. The objective of this study is to explore these impacts. The result shows that 60% of marginal people have received the vaccine whereas 40% of marginal people have not yet received the vaccine. This study demonstrates that 76% of marginal people have taken debt during the covid-19. Among them, 13% could not repay their loans. By examining the multifaceted dimensions of the pandemic’s impact, this abstract contributes to a deeper understanding of the challenges faced by marginalized populations in the context of a global health crisis and calls attention to the need for targeted interventions and support in the post-COVID era.
Характеристика феминитивов в русскоязычном медийном дискурсе
Authors: Смирнов Иван
Published: January 2024

В статье представлены предварительные комментарии, объясняющие популярность феминитивов, и аргументация, касающаяся причин появления новых форм в русском языке.
В русскоязычном медийном пространстве функционирует ограниченное количество лексических единиц, которые активно используются и критикуются коммуникантами. Новоявленные модели феминитивов репрезентируют женщин, деятельность которых связана с масс-медиа, сферой искусств, образованием. Отсутствуют профессионализмы, относящиеся к рабочим специальностям, успешно освоенным женщинами. Непродуктивность морфологических трансформаций новых лексем является результатом использования небольшого числа приемлемых суффиксов, находящихся в распоряжении участников дискурса.
Феминитивы новой волны, как средство борьбы участников феминистического движения и действенных представителей блогосферы за русскоязычное медийное пространство, указывают не только на присущность субъекта к определенной профессиональной деятельности, но и участвуют в маркировании гендерной принадлежности человека. Фактором, тормозящим процесс распространения феминитивов в различных медиаконтентах, является нарушение системности в языке, например, влияние акцентологических правил русского языка на создание новых лексических вариантов активными участниками феминистских движений были заложены концептуальные рамки, позволяющие использовать лимитированное количество возможных моделей феминитивов.
Синергетический анализ словообразовательных процессов как реакции на казахстанскую действительность
Authors: Жапарова Тогжан
Published: January 2024

В статье язык описывается не просто как способ общения, а как сложная и открытая система, способная реагировать на происходящую действительность. Подвергаясь влияниям извне, система языка утрачивает равновесность. Этот процесс усложняется в связи с перманентным потоком информации и ее обменом с внешней средой. В центре внимания находятся периоды переходного момента, замена на новое, обусловленная неупорядоченностью, образованием диссипативной системы, сопровождающаяся энтропией, периодом образования нового – бифуркационным процессом, а также притяжением (аттрактором) динамической системы, что приводит к частотным употреблениям и развитию словообразовательных форм. Это способствует формированию коррекции нормы или приобретению иных черт. Мы наблюдаем, как новые элементы укореняются в языке и в процессе функционирования двух языков – казахского и русского. Актуальность исследования заключается в анализе процесса возникновения словообразовательных явлений во время январских событий 2022 г. в Казахстане, показанных в современных средствах массовой информации.
Весь процесс рассматривается с позиции синергетики. В данном случае синергетика дает возможность видеть в ней подходы для анализа изменений в языке посредством достижения точки равновесия, адаптации и принятия языковых элементов.
Цель данной статьи – определить и изучить синергетический аспект адаптации словообразовательных форм в иноязычной среде, где определяется выбор из множества того, что является признанным в настоящее время. В статье отражаются базовые понятия данного направления в современной лингвистике.
Психологическая символика сновидений в творчестве Ф.М. Достоевского
Authors: Zacharova Erica
Published: January 2024

В статье рассматривается феномен сновидений в художественном тексте, в творчестве писателя-психоаналитика Федора Михайловича Достоевского, который относится к авторам Золотого века русской литературы и считается одним из самых важных представителей русской и мировой литературы.
Сны сопровождают человека с древнейших времен, поэтому очень интересно наблюдать за их значением не только в психологической, но и в литературоведческой интерпретациях. В художественном тексте можно заметить символику и значение сновидений, а также проанализировать распространенность сновидений в определенном тексте.
В романе Преступление и наказание (1866) изображено конкретно пять снов. Первые два сна приснились главному герою романа незадолго до совершения преступления, следующие два сна – после совершения преступления, а последний сон – во время принудительных работ в Сибири. Для анализа был избран второй сон, анализ которого опирается на теоретическую базу символики сновидений (в психологии), в частности на теории швейцарского психолога и психиатра К.Г. Юнга (архетипальные образы) и американского психолога Дж. Хиллмана (мифологические образы).
Путем анализа избранного произведения статья интерпретирует возможную психологическую символику сна Родиона Раскольникова, замечает его смысл и старается эксплицитно и имплицитно показать символику данного сна. Цель статьи – исследовать (психологическое) значение снов как подсознательного конструкта литературного персонажа.
Слово о конференции «Чувства и ценности, которые спасут мир» (в языке, литературе и культуре)
Authors: Nevzorova-Kmech Elena
Published: January 2024

Данный текст представляет собой описание мероприятия и краткий анализ его результатов. Речь идет о Международной студенческой научной конференции «Чувства и ценности, которые спасут мир», которая состоялась 6 мая 2023 года. События, происходящие в разных частях света, сподвигли студентов и их руководителей обратиться к теме чувств, эмоций, ценностей человека.

На конференции были проанализированы тексты прозвучавших докладов и сделаны выводы, что поле исследования затронутых молодыми исследователями проблем может и должно быть транспонировано на другие научные дисциплины. Докладчики не смогли строго придерживаться рамок одной научной области. Сама тема провоцирует на проведение междисциплинарных исследований. Доклады (статьи), хотя и находятся в рамках языкознания, однако опорой далеко выходят за узкое понимание лингвистических исследований, а именно опираются на достижения литературоведения, философии, психологии, социологии и биологии.

В рамках конференции были рассмотрены разные подходы к пониманию чувств и эмоций, а также их влияния на поведение и коммуникацию. Работы лингвистов показали, как эмоции выражаются через язык и как это влияет на восприятие и коммуникацию.

В целом, конференция была посвящена комплексному изучению чувств, эмоций и их роли в мире. Она явилась хорошим стартом в научной карьере ее участников. Мероприятие позволило молодежи приобрести опыт и вместе с тем уверенность в себе. Конференция дала возможность установить и укрепить международные контакты. Следовательно показала, насколько наука является важной и даже спасительной ценностью в современном мире.
Use of Artichoke (Cynara scolymus) Flower Extract as a Substituteto Rennet in the Manufacture of Camel Milk Cheese
Authors: Fguiri I. , sboui A. , atigui M. , Arroum S. , Dbara M. , Hammadi M. , Khorchani T.
Published: January 2024

Background: The present study aims to improve coagulation abilities of camel milk using enzyme extracts from artichoke. Methods: The properties of purified extracts were studied in this research and a cheese was manufactured with artichoke extracts. Results: It showed an extraction yield of 38.83% and optimum coagulation conditions of the artichoke enzyme extract were: pH=5; temperature= 55°C; CaCl2 concentration= 0.01M and optimal enzyme concentration= 1%. A fresh cheese made from camel milk with a particular nutritional quality, consistency. The artichoke proteases displayed chymosin-like properties and thus hold the best potential for use as a milk coagulant in cheese production.
Morphological and SSR Marker based Selection for an Elite YMV Resistant Breeding Line from a Segregating Population of Soybean [Glycine max (L.) Merrill]
Authors: Sahu D. , Gill B. Singh , Sirari A. , Pradhan M. , Sahu N. , Kumar A. , Rani A.
Published: January 2024

Background: JS335 is a leading variety of soybean in central India with high stability, but YMV susceptible. These leads to the incorporation of the YMV resistance in the elite genotypes of soybean variety JS335. Methods: 45 breeding lines obtained from a cross between two parents SL525 (YMV resistant) and JS335 (YMV susceptible) along with two parents and a check SL958 were analysed for diversity using Mahalanobis D2 and 19 polymorphic SSR markers. These lines were evaluated for yield and component traits and YMV, during 2020 at two locations viz. Ludhiana and Gurdaspur, India. Result: Diversity analysis based on Mahalanobis D2 statistics divided genotypes into five clusters. The maximum (288464.1) and minimum (15103.7) inter-cluster distance were observed between clusters 4 and 5 and clusters 2 and 5, respectively. SSR marker analysis grouped a total of 48 genotypes into three major clusters. The mean for agronomic traits of genotypes was categorised and SLJS 41-2 was found YMV resistant and exhibited a high yield (32.1 g/plant). The contribution of JS 335 towards SLJS 41-2 was found to be 62.5%. This line could further be tested at multilocation to evaluate adaptability and subjected to different yield trials for varietal release or used as a potential YMV donor.
Describing Nurses’ Work and Educational Needs in Providing Neonatal Palliative Care: A Narrative Review
Authors: St. Louis Julia , Benzies Karen , Raffin-Bouchal Shelley , Sinclair Shane
Published: January 2024

Nurses in NICUs report insufficient education as a persistent barrier to providing quality neonatal palliative care (NPC). Since existing literature on educational interventions in NPC is limited, this review aimed to identify and narratively synthesize literature both about nurses’ attitudes toward NPC and the NPC education received by nurses. We conducted a nonsystematic narrative literature review. Four themes were identified from the 28 articles included in this review. These were as follows: (a) nursing work in NPC, (b) NICU nurses’ experiences and perceptions of NPC, (c) facilitators and barriers to nursing work in NPC, and (d) educational interventions in NPC. This literature review identified studies about NICU nurses’ experiences and education in providing NPC. NICU nurses both desired and lacked education in NPC. This literature review identifies the importance of developing and evaluating NPC education for nurses.
Knowledge Preservation: Need for a Multi-pronged Approach – Lessons from Ancient Indians
Authors: Srinath Kanchi Vijay
Published: January 2024

The leaps and bounds with which the knowledge domain of our modern civilization is growing pose a formidable challenge as to how this wealth of knowledge is to be preserved for posterity. Are we sufficiently prepared should there be any cataclysm of gigantic proportions or a major catastrophe such as a nuclear war? What if the whole world is thrown awry and crippled by such major events? How do we ensure that future generations of humans who would have inherited a substantially destroyed world can rebuild it back to its glory? How to safely supply the wealth of knowledge we amassed from modern advancements in science and technology to those generations who have to rebuild everything from scratch? This paper examines the techniques espoused by our wise ancient Indian sages to transmit knowledge to posterity across many millennia, the wisdom and philosophy behind such adopted measures and whether there are lessons for us to learn from them.
IZRAŽAVANJE OBELEŽJA DIMENZIONALNOSTI I DIREKTIVNOSTI U FRANCUSKOM I SRPSKOM JEZIKU
Authors: Vilić Ivana
Published: January 2024

Dimenzionalnost izražava geometrijske osobine lokalizatora i objekta lokalizacije i u teoriji konceptualne semantike predstavlja se kao obeležje sa četiri vrednosti – 0DIM (tačka), 1DIM (linija), 2DIM (površina) i 3DIM (zapremina), dok je direktivnost vezana za dinamičke aspekte lokalizacije u prostoru. Francuski i srpski jezik na vrlo sličan način izražavaju odnos prileganja objekta na površinu (dvodimenzionalnost) i odnos sadržavanja u unutrašnjosti lokalizatora (trodimenzionalnost). Kada je reč o punktuelnoj i jednodimenzionalnoj konceptualizaciji prostornih odnosa, vezanim za dinamičke aspekte, francuski i srpski jezik se razlikuju. Francuski jezik koristi predlog à da izrazi punktuelnu konceptualizaciju i put kojim će objekat biti lokalizovan, te tako implicitno izražava Putanju. Srpski jezik, međutim, akuzativom obeležava Putanju i cilj u procesu kretanja.
СРБИ У СЕГЕДИНУ ИЗМЕЂУ 1686. И 1716.
Authors: Нинковић Ненад
Published: January 2024

Када се хабзбуршка војска приближила у јесен 1686. Сегедину у његовој околини је затекла српско становништво које јој се придружило у освајању града. У то време Срби су играли важну улогу и у самом граду, где је, уз тврђаву, било седиште православног бачког епископа. Српска популација је у граду увећана Великом сеобом из 1690. поготово, јер је Сегедин до 1716. као погранично место био примамљив за бројне српске трговце. Сегединска тврђава је представљала најзначајнију фортификацију у овом делу границе Хабзбуршке монархије и Османског царства, тако да су се Срби у њему по оснивању Потиске и Поморишке војне границе нашли као војници. Таква позиција је Сегедину наменила важну улогу у време Ракоцијевог устанка (1703-1711) током којег захваљујући и српским војницима град није пао у руке устаника, али је зато пуно страдала његова српска околина.
Serum IL-17 levels correlate with urinary albumin in systemic lupus erythematosus (SLE) pregnant mice model
Authors: Wahyuni Sari , Pratiwi Agustina Ida , Mawaddah Sofia , Iswati Retno Setyo
Published: January 2024

Women of reproductive age are more likely to have systemic lupus erythematosus (SLE), which frequently results in health issues, particularly during pregnancy. A normal pregnancy's first trimester shows a marked increase in the percentage of Th17 cells, which then steadily declined in the second and third trimesters. Meanwhile, IL-17 level increases in SLE-affected pregnant women. This study aimed to analyze the correlation between serum IL-17 and pregnancy outcome (fetus weight, blood pressure, urinary albumin) in SLE pregnant animal models. Twenty mice were randomly divided into two groups, including the normal pregnant group and SLE-pregnant group. The SLE pregnant mice was made by intraperitoneally induction of 0.5 mL pristane. Serum IL-17 was assayed by enzyme-linked immunosorbent assay (ELISA) method. The serum IL-17 level, the blood pressure and urinary albumin were significantly higher in the SLE pregnant mice group than those of the normal pregnant group (p< 0.05). The weight of fetus was significantly smaller in the group of SLE pregnant mice group than the normal pregnant group (p< 0.05). There was a significantly positive correlation between the serum IL-17 level and urinary albumin (p = 0.042; r = 0.459). In conclusion, serum IL-17 levels correlate with urine albumin in SLE pregnant models, but do not correlate with fetus weight and blood pressure.
A rare case of Salmonella sp septic arthritis in a patient with systematic lupus erythematosus (SLE)
Authors: Steffanus Mario , Yusuf Cindy , Hadiyanto Jessica Novia
Published: January 2024

Septic arthritis is considered as a medical emergency which can lead to significant morbidity and cause substantial mortality, especially if the diagnosis is delayed. Prolonged use of immunosuppressive and cytotoxic medications as therapy for systemic lupus erythematosus (SLE) causing patient susceptible to secondary infection. However, septic arthritis due to Salmonella sp. is very rare,  makes this is an important extraintestinal manifestation especially in immunosuppressed patients. We presented a case of 25 y.o. female diagnosed with SLE 3 m.o. earlier presented with fever and arthritis on her left genu for 1 wk duration. Genu ultrasonography showed synovitis genu sinistra with fluid volume of 1-2 cc on recessus lateral genu sinistra. The patient was further analysis on her synovial fluid was conducted, the gram stained smear of the fluid showed >25 leucocytes, low power field, and Salmonella sp. was isolated from her synovial fluid analysis. The patient was given intravenous ciprofloxacin and discharged home well. Septic arthritis should always be considered in any patients on long-term immunosuppression state who present with acutely swollen joints. It considered as an important medical emergency with high mortality and morbidity. Hence, prompt recognition, joint aspiration with administration of systemic antibiotics and appropriate surgical intervention plays a pivotal role to minimize morbidity and mortality.
Complete recovery of severe coronavirus disease 2019 (COVID-19) infection in an obese patient
Authors: Susanti Vina Yanti , Anggraeni Vita Yanti , Akbar Adrianus , Leo Benedreky
Published: January 2024

There is strong evidence indicating that excess adiposity in obesity impacts immune function and host defence. However, almost no known mechanism of how the immune and host defence are affected by the low-grade inflammatory response of the obese has been established. The significance of altered immune response in obesity was presumed to be an independent risk factor for increased morbidity and mortality following the influenza pandemic back in 2009. Similarly, obesity is linked with a higher risk of severity and a worse clinical outcome of severe acute respiratory coronavirus 2 (SARS-COV-2) infection.This case reports a complete recovery of a severe coronavirus disease 2019 (COVID-19) infection despite having morbid obesity aggravated by metabolic syndrome.
Gut dysbiosis and the role of probiotics in chronic kidney disease
Authors: Cahyadi Alius , Yuwono Angelina , Subagio Stephanie Widodo , Iryaningrum Maria Riastuti
Published: January 2024

Chronic inflammatory condition in chronic kidney disease (CKD) patients is associated with increased risk of cardiovascular morbidity and mortality. Gut dysbiosis is assumed as one of leading factors to the chronic inflammatory condition. The relationship between the kidney and the gastrointestinal, knowns as the gut-kidney axis, has a role in production and accumulation of uremic toxins derived from gut microbial fermentation of protein, and translocation of endotoxins and microbial from gut lumen into bloodstream due to alterations of intestinal epithelial barrier in CKD patients. Probiotics supplementation is one of the optional theraphy to restore the gut dysbiosis in CKD patients. Recent studies found that probiotics supplementation in CKD patients decreased uremic toxins and pro-inflammatory cytokines production, and delayed CKD progression. The improvement of this chronic inflammatory condition is expected to decrease cardiovascular disease risk in CKD patients. This review aims to describe the importance of gut-kidney axis in CKD patients, particularly in gut dysbiosis, and the role of probiotics in progression of CKD.
Moringa oleifera Lam. to accelerate wound healing: a review
Authors: Jaya Fidi Bhawana , Syamsunarno Mas Rizky Anggun Adipurna , Sahiratmadja Edhyana
Published: January 2024

An injury to the skin that disrupts the soft tissue may form a wound. The healing process in response to injury is a dynamic and well-regulated process of cellular, humoral, and molecular mechanisms that consists of four partly overlapping phases: hemostasis, inflammation, proliferation, and remodeling. An impaired wound-healing process may cause a formation of an abnormal scar and chronic wounds, leading to a reduced life quality. Therefore, it needs an optimal prevention strategy. Many modalities have been claimed to accelerate wound healing. The trend of using natural products is increasing in most Southeast Asian countries due to their biodiversity. Nowadays, studies on natural compounds are increasing to accelerate wound healing. Moringa oleifera Lam. is a high-value plant that each part of it has a high nutritional value as well as a great range of medicinal uses, including anti-inflammatory, antimicrobial, antioxidant, and wound healing properties. In this review, we have explored the M. oleifera that are very rich in vitamins, minerals, fatty acids, and phytochemical compounds like quercetin, kaempferol, and vicenin-2, that play a role in the wound healing process. Moreover, these compounds may enhance the healing of wounds with pathological conditions such as diabetes, immunocompromised and persistent infection.
Corrigendum: Effects of 7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-chroman-4-one on serum levels of antioxidant enzymes in hyperlipidemic rats
Authors: Prasetyastuti . , Gama Noviyanty Indjar , Ayunda Rahmah Dara
Published: January 2024

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HIMPUNAN DOMINASI TERKENDALI GRAF HASIL OPERASI AMALGAMASI TITIK DAN SISI PADA GRAF SIKLUS BERORDE SAMA
Authors: Maro Landerius
Published: January 2024

Teori graf merupakan salah satu ilmu terapan matematika yang hingga kini terus dikembangkan. Salah satu konsep yang dipelajari dalam teori graf adalah himpunan dominasi terkendali yang bertujuan untuk menentukan bilangan dominasi terkendali graf hasil operasi amalgamasi titik dan sisi pada graf siklus berorde sama, atau (a𝑚𝑎𝑙(,,)) dan (a𝑚𝑎𝑙(,,,)). Penelitian ini menggunakan metode pembuktian dengan memanfaatkan teorema yang telah ada, yaitu teorema bilangan dominasi terkendali pada graf siklus dan teorema batas atas dan batas bawah bilangan dominasi terkendali. Adapun hasil yang diperoleh, yaitu: untuk, dan untuk dimana , dan untukdimana.
Reflection in teaching: Goals, techniques, contradictions
Authors:   Kazan Federal University, Maklakova Natalia V. , Maklakov Ivan A. ,   Russian International Academy of Tourism (Kazan branch)
Published: January 2024

The article presents an analysis of the current state of reflexive teaching process (RTP), which today receives serious attention in domestic and foreign theory and practice of teaching due to the fact that improving the quality of education requires special attention to the personality of the teacher as the central link of the entire educational process, its system-forming component. An original interpretation of this concept is proposed through the understanding of RTP as a crosscutting pedagogical practice that accompanies the teacher throughout his/her professional activity, which allows overcoming the existing diversity of approaches to its interpretation in the context of actual goals and objectives. Special attention is paid to reflexive teaching (RT). The subject of RT is a teacher who evaluates his/ her own teaching practice, studies the effectiveness of his/her choice of curricula, materials, methods and techniques, taking into account feedback from students and colleagues and making changes to the teaching process to increase its productivity. Whereas the subject of reflexive learning is a student reflecting on his/her learning experience, studying his/her own learning strategies and making adjustments to improve his/her own results. The techniques of RT and the problems faced by teachers in the process of its implementation in practice are investigated. Based on the analysis, contradictions in the theory and practice of RT underlying these problems are revealed.
Capitalismo, pandemia e a ética do cuidado
Authors: Sá dos Reis Edson
Published: January 2024

A pandemia ainda está presente no cotidiano. Isto faz com que a reflexão sobre ela seja essencial para problematizar nosso modo de vida e nossos direcionamentos éticos. Este escrito pretende pensar o modo de organização capitalista como gerador de pandemias. Como sistema que age a partir do modus operandi predatório, o capitalismo oferece grandes possibilidades para liberação e circulação de patógenos, bem como sua mutação. A partir das pesquisas do filogeógrafo Rob Wallace, apresentaremos como o atual modo de produção se constitui o principal responsável pela crise pandêmica. Isto nos leva a indagar sobre um outro ethos possível. Que alternativa ética pode se contrapor ao ethos capitalista? Há algum princípio fundamental que possa guiar a ação em contraposição ao modelo atual? Nosso objetivo será estabelecer a ética do cuidado como esse modelo capaz de se pôr contrário ao padrão predatório e competitivo do capitalismo.
medo como marca da tirania no "De Clementia" de Sêneca
Authors: Santos Luz Bueno Taynam
Published: January 2024

Procura-se apontar, neste texto, o papel do medo enquanto marcador da legitimidade do princeps. Isto é, a partir da leitura do De Clementia, pretende-se demonstrar que, para Sêneca, tão distinta quanto a virtude da clemência é para o bom governante, o medo é para o tirano. Se a clemência revela a natureza racional e pacífica do governante, de modo inverso, o aparecimento do medo no corpo político revela a natureza destemperada e violenta dos tiranos. Assim, alinhado com os ensinamentos estoicos, o autor romano estabelece um conjunto de marcadores capazes de identificar, de um lado, o bom governante por suas virtudes, qualidades e pela tranquilidade e segurança de si e seu corpo político e, de outro, seu extremo oposto, mostrando que a presença do medo (tanto em si quanto no corpo político) é insígnia de governos tirânicos, levando-os à ruína assim como as paixões arrasam aqueles que as possuem.
Rikkosan’s Short-term Analgesic Effect of Burning Mouth Syndrome: A single-arm cohort study
Authors: Itagaki Tatsuki , Nakamura Keisuke , Tanabe Tougo , Shimura Takumi , Nakai Yu , Sakata Ken-ichiro , Sato Jun , Kitagawa Yoshimasa
Published: January 2024

Burning mouth syndrome (BMS) is a chronic oral pain disorder. There is a theory that BMS is nociplastic pain. Standard treatment for BMS has not yet been established. Kampo medicine is a traditional oriental medicine. The purpose of this study is to validate the effectiveness of rikkosan—a traditional Japanese herbal medicine (Kampo)—in the treatment of BMS. Statistically designed a single-center retrospective study was conducted in 20 patients who were diagnosed with BMS and treated with rikkosan alone (7.5 g) three times daily. Patients were asked to evaluate their pain using a numerical rating scale (NRS) or a visual analogue scale (VAS) at the time of the initiation of rikkosan and at 1 month after. They had an average age of 63 years and 90% were being treated for other illnesses, but their medication status was the same during this study period, except for rikkosan. No side effects were observed in patients. NRS or VAS/10 scores decreased significantly between the time of the initiation of rikkosan and the one-month after (-2.1 ± 1.2, p < 0.05). Rikkosan including the placebo effect has a short-term effect of reducing NRS by two levels in BMS patients.
Polymer Delivery Systems for Long-Acting Antiretroviral Drugs
Authors: Nayan Mohammad Ullah , Panja Sudipta , Sultana Ashrafi , Zaman Lubaba A. , Vora Lalitkumar K. , Sillman Brady J. , Gendelman Howard E. , Edagwa Benson
Published: January 2024

Long-acting (LA) drug-delivery system (DDS) successes are linked to their abilities to harness biocompatible polymers and materials for sustained and predictable release of therapeutic agents over an extended period of time. For human immune deficiency virus type one (HIV-1) infections, LA DDSs hold great promise in closing the gaps of daily oral therapy for treatment and prevention. Examples are Cabenuva, Apretude and Sunlenca, which have been shown to be safe and effective. Alternative promising drug delivery technologies such as implants, prodrugs, vaginal rings, and microarray patches are being explored to further meet patients’ needs. We posit that improved physicochemical properties of the formulation payloads and material chemistry design with optimal drug release kinetics holds the potential to optimize release profiles. Furthermore, for the treatment and prevention of HIV-1 infection, the landscape of LA medicines now in clinical or preclinical development offers hope that the strategic design of polymers will further improve upon controlled delivery of drugs to simplify dosing schedules.