bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of prognostic indicators and markers of endometrial carcinoma based on shared metabolism-related genes in gynecological tumors.
Authors: Zheng Liuqing , Wang Yanwei , Wang Li , Meng Yiran
Published: June 2024

e17589

Background: Aberrant metabolism is a major characteristic of cancer and it is important to determine whether there is a common metabolic genetic signature among gynecological cancers. Endometrial cancer, as one of the gynecological tumors, has shown increasing morbidity and mortality rates annually. Investigating shared metabolic molecular markers in gynecological tumors can enhance our understanding of endometrial cancer. Methods: Transcriptome data for gynecological tumors, including ovarian cancer (OV), endometrial cancer (UCEC) and cervical cancer (CESC) were obtained from The Cancer Genome Atlas database. Transcriptome data for normal cervix uteri, uterus and ovary tissues were downloaded from the Genotype-Tissue Expression Project. Metabolism-related gene sets were sourced from the Kyoto Encyclopedia of Genes and Genomes for subsequent analysis (KEGG) for subsequent analysis. Weighted gene co-expression network analysis (WGCNA) was employed to identify gene modules associated with OV, UCEC and CESC. The intersection of three cancer-related modules and metabolism-related gene sets yielded shared SMRGs (Shared Metabolism-Related Genes). UCEC samples were randomly divided into training set and testing set by caret R package in a 5:5 ratio. A risk model based on SMRGs, capable of predicting the overall survival (OS) of UCEC patients, was constructed using LASSO regression and Cox regression analyses. Results: A total of 463 genes were identified as sharing SMRGs through the intersection of modules. And 81 genes associated with OS was further selected by Univariate Cox regression analysis combined with expression and clinical data. Eventually, 8 genes (CYP11B1, SRD5A1, OTC, ACACB, ASS1, ALG3, PLA2G4F and POC1B-GALNT4) were screened out by LASSO regression analysis to construct the prognostic characteristics. The training set was divided into high and low-risk groups based on the computed risk threshold. Kaplan-Meier analysis demonstrated that patients in the low-risk group exhibited better prognosis. Similar differential survival results were observed in the testing and entire sets. Furthermore, analysis of immune and stromal infiltrates indicated increased infiltration of CD8+ T cells in the low-risk group, and PLA2G4F was identified as the core gene. The expression level of PLA2G4F increased with the progression of UCEC and was closely associated with various immune checkpoint factors, including CD48, HAVCR2, CD86, TIGIT, CTLA4 and BTLA. Conclusions: This study established a shared metabolism-related gene prognostic model applicable to gynecological cancers and analyzed its potential role in the treatment and prognosis assessment of endometrial cancer. Additionally, PLA2G4F was identified as a potential immune-related biomarker for UCEC patients.
Neoadjuvant immune checkpoint blockade in mismatch repair deficient endometrial cancer: An update on recurrence-free survival and correlative biomarkers.
Authors: de Bruyn Marco , Eerkens Anneke L. , Brummel Koen , Vledder Annegé , Paijens Sterre T. , Requesens Marta , Loiero Dominik , van Rooij Nienke , Plat Annechien , Haan Floris-Jan R. , Klok Patty , Church David , Wardenaar René , Foijer Floris , Koelzer Viktor , Bosse Tjalling , Bart Jos , Jalving Mathilde , Reyners An K.L , Nijman Hans
Published: June 2024

e17593

Background: We recently reported 37.5% radiologic and 50% pathologic response rates in a phase I feasibility study of neoadjuvant pembrolizumab in 10 mismatch repair deficient (MMRd) endometrial cancer (EC). Based on the safety data and promising responses, a phase II study with extended neo-adjuvant treatment has been initiated. Here, we provide an update on the recurrence-free survival (RFS), and unique correlative clinicopathologic, genomic and immunologic biomarkers from the phase I trial. Methods: Tumor differentiation, (germline) mismatch repair status, immune cell distribution, presence of tertiary lymphoid structures (TLSs), T cell receptor (TCR) diversity and common driver mutations (TSO500) were analyzed. Patients were stratified by radiologic or major pathologic responses. RFS was determined from time of surgery. Results: Two recurrences have been observed in non-responding patients, with a median and longest disease-free survival of 17 and 26 months, respectively. Responding patients were characterized by dedifferentiated histology (grade 3), somatic MMRd, and a monoclonal T cell expansion, which was evaluable in the interim biopsy. Neither common driver mutations, nor variants of unknown significance from the TSO500 panel were related to response. Pre- and post-treatment T cell and B cell densities were not correlated with response, nor was the presence of TLS. Pembrolizumab-responsive T cell clones could be detected in peripheral blood prior to initiation of treatment, remained constant throughout treatment duration and were detected in post-treatment tumor-draining lymph nodes (TDLN). Conclusions: Neoadjuvant pembrolizumab is associated with monoclonal T cell expansion in responding patients, which can be evaluated using pipelle biopsy. Repeat assessment of TCR clonality during extended neoadjuvant treatment is currently being evaluated. Clinical trial information: NCT04262089 .
Demographics, pathologic characteristics, and pattern of recurrence of vulvar cancer at an academic hospital in South Africa: A 10-year retrospective review.
Authors: Sajo Adekunle Emmanuel , Mnisi Edwin , Visser Cathy , Bassa Sheynaz , Dreyer Greta
Published: June 2024

e17602

Background: Vulvar cancer although uncommon, accounts for about 5% of all gynecologic malignancies. Globally, it accounted for over 45 000 new cases and 17 000 deaths in the Globocan 2020 cancer estimates with an age-standardized rate (ASR) for incidence and mortality of 0.9 and 0.3 respectively. Vulvar cancer shares common risk factors with cervical cancer and over 90% of these are squamous cell carcinoma. In Africa, there is paucity of data on the true prevalence and recurrent rate of vulvar cancer albeit due to its rarity or poor record keeping. The current study aimed to describe the demographics, pathological characteristics and recurrence pattern of vulvar cancer at a single academic institution in South Africa. Methods: This was a retrospective descriptive observational study of vulvar cancer cases at the Gynaecologic Oncology Unit of Steve Biko Academic Hospital, Pretoria between 1st January 2012 and 31st December 2021. Data was extracted from the participants medical records on the demographics, medical history, site of tumour, disease stage, histologic characteristic and disease recurrence. The 2009 FIGO staging was used to classify the disease stage. Results: A total of 317 patients were included for analysis. The mean age was 45±12 yrs (range: 12-87). Majority were below 50yrs (71.9%) while 28.1% were 50yrs and above, 77.9% were HIV positive (median CD4 count was 428 cells/mm3, IQR= 277-662), 19.2% were HIV negative while the HIV status of 2.9% were unknown. The mean hemoglobin level at presentation was 10.7 ± 2.4g/dl. The average interval between biopsy at local clinic and presentation at the gynaecologic oncology clinic was 80days. The average number of patients seen was 31.7 per year. The majority, 79.1%, had tumours >4cm. Only about 45% of the patients had multifocal lesions. The left vulvar was significantly more affected than the right, 57.3%, (p 0.001). The anus was the most frequent contiguous structure involved in vulvar cancer, 47.5%. Squamous cell carcinoma was diagnosed in 96.5% of the participants and the most common histological grade was grade 2, at 69.9%. A large proportion of the participants,63%, presented in advanced stage (Stage 3 & 4). The mean follow up period was 23.1±26 months. The recurrence rate was 16.4%, of which 49% were local recurrence, 10.2% occurred in the groin, 22.5% involved the local and groin sites together, and 18.3% occurred at distant sites. Conclusions: Our data showed that the demographic characteristics of local patients with vulvar cancer are different from those in the developed world. The high recurrence rate might be due to the advanced disease at presentation of the majority of the patients.
Gynecologic malignancies in women younger than 40 years of age: A SEER database review.
Authors: Shah Princy , Kela Kashyap , Hegde Upendra P.
Published: June 2024

e17605

Background: Gynecologic malignancies are one of the most common types of cancers in women, but their Epidemiology in young women is not widely known. Here we present the demographics and comparison between uterine, cervical, ovarian, vagina, and vulvar cancers in women under age 40 years based on the Surveillance, Epidemiology, and End Results (SEER) database analysis. Methods: Information was collected from the SEER database November 2022 with the data from years 2000-2020 containing 17 registries. Site recode ICD O-3/WHO 2008 Female Genital system was applied and Primary sites labeled 51.8 to 56.9 were selected. Patient population with only one primary site of Malignancy was included, and the cases with No specific sites were excluded. Age recode 0-39 years was applied. Variables of Age group, Race, Ethnicity, Median household income, Areas of residence & survival months were selected. Data was extracted for a total of 34056 patients. The Chi-square test was used for statistical analysis. P value <0.05 was considered significant. Results: The most common site of Gynecologic cancer was Cervix (50.4%) followed by Uterus (24.2%) and Ovary (23%). Vulvar(1.9%) and Vaginal (0.6%) cancers were the rarest. Squamous cell carcinoma was the most common histology for cervical (42.9%), vaginal (26%), Vulvar (51%) cancer versus Endometrioid histology for uterine (69.2%) and teratoma for ovarian (12.5%) cancer. The most common age group affected was 34-39 (44.1%) with decreasing frequency with younger age. 30.5% of participants belonged to 30-34 years of age. A total of 14 cases were noted in patients less than 1 year of age with most cases of vaginal and ovarian cancer. Non-Hispanic whites had the highest occurrence (48.8%) followed by Hispanics (28.4%), Blacks (10.7 %), Asian/Pacific Islanders (9.7%), and Alaskan/American natives (1.2%). Compared to high household income, patients with lower household income of <75,000 US dollars (USD) comprised of 61.9% of total Gynecologic malignancies. 89% of the total cases were observed in Metropolitan cities versus non-metropolitan areas. 5-year survival rate was observed at 57% overall. Vulvar cancer had the highest survival rate of 60.1% followed by Uterine (57.9%), Vaginal (57.1%), Cervix (56.1%), and Ovarian (56%) cancer. Conclusions: Early onset Gynecologic malignancies are more common in non-Hispanic whites, in Median Household income <75,000 USD, and in Metropolitan cities. Incidence increases with age. Vulvar cancer has the best 5 years survival and Ovarian has the worst one. Cervical cancer (50.4% of total cases) screening should be continued as per current guidelines. However, with Uterine and Ovarian cancers collectively contributing to close to half the Gynecologic malignancies, Practitioners should maintain high clinical suspicion to have appropriate individualized workups based on Risk Factors for early Diagnosis and Management of these cancers in this age group.
CYP11A1 inhibitor MK-5684 versus next-generation hormonal agent (NHA) switch in patients with metastatic castration-resistant prostate cancer (mCRPC) after NHA and taxane-based chemotherapy: Phase 3 MK-5684-003 trial.
Authors: Yu Evan Y. , Song Yue , Poehlein Christian Heinrich , Schloss Charles , Antonarakis Emmanuel S.
Published: June 2024

TPS5113

Background: Androgen receptor (AR) signaling remains a key driver of prostate cancer even after progression on androgen-directed therapies. Activating AR ligand binding domain (AR-LBD) somatic point mutations are a common mechanism of resistance to androgen-directed therapies in patients with mCRPC. MK-5684 (ODM-208) is an oral, nonsteroidal inhibitor of cytochrome P450 11A1 (CYP11A1), which catalyzes the first and rate-limiting step of steroid biosynthesis. Inhibition of CYP11A1 by MK-5684 suppresses the production of all steroid hormones and their precursors that may promiscuously activate the AR signaling pathway. In the phase 1/2 CYPIDES trial, MK-5684 showed antitumor activity in patients with heavily pretreated mCRPC, especially in those with AR-LBD mutations. The randomized, open-label, phase 3 MK-5684-003 trial (NCT06136624) is evaluating the efficacy and safety of MK-5684 versus NHA switch in patients with mCRPC previously treated with NHA and taxane-based chemotherapy. Methods: Eligible patients havemCRPC (unselected for AR-LBD mutations) that progressed on androgen deprivation therapy ≤6 months before screening and during or after treatment with 1 NHA for nonmetastatic (nm) hormone-sensitive prostate cancer (HSPC), nmCRPC, mHSPC, or mCRPC for ≥8 weeks (≥14 weeks with bone progression), and also progressed during or after 1 or 2 taxane-based chemotherapies for mCRPC. Approximately 1200 patients (300 with and 900 without AR-LBD mutations) will be randomly assigned 1:1 to receive MK-5684 5 mg PO BID (+ dexamethasone 1.5 mg and fludrocortisone 0.1 mg QD) or enzalutamide 160 mg PO QD (if prior abiraterone) or abiraterone acetate 1000 mg PO QD (+ prednisone 5 mg BID; if prior enzalutamide/darolutamide/apalutamide). Randomization to treatment will be stratified by measurable disease (yes/no), disease AR-LBD mutation status (positive/negative), and prior cabazitaxel use (yes/no). Treatment will continue until radiographic disease progression (verified per Prostate Cancer Working Group 3 [PCWG3]–modified RECIST v1.1 by blinded independent central review [BICR]), unacceptable toxicity, or other discontinuation criteria are met. Tumor assessments will be performed every 8 weeks up to week 24, then every 12 weeks thereafter. Dual primary end points are radiographic PFS (per PCWG3-modified RECIST v1.1 by BICR) and OS in patients with AR-LBD mutation-positive and -negative disease, separately. Secondary end points include time to initiation of first subsequent anticancer therapy or death; ORR and DOR per PCWG3-modified RECIST v1.1 by BICR; time to pain progression; time to prostate-specific antigen progression; time to first symptomatic skeletal-related event; and safety and tolerability. Enrollment is ongoing. Clinical trial information: NCT06136624 .
A conversational agent as a personal and professional development tool for healthy aging and sustainable living
Authors: Καρυωτάκη Μαρία
Published: June 2024

Η παρούσα διδακτορική διατριβή με τίτλο: “Ένας διαλογικός πράκτορας ως εργαλείο προσωπικής & επαγγελματικής ανάπτυξης για την υγιή γήρανση και την υγιεινή διαβίωση” προσεγγίζει διαθεματικά την προαγωγή της γνωστικής και ψυχικής υγείας, αξιοποιώντας τις τεχνολογίες της πληροφορίας με απώτερο σκοπό την ένταξη και ενσωμάτωση της γνωστικής και ψυχικής υγείας σε προγράμματα συνεχιζόμενης εκπαίδευσης και δια βίου μάθησης. Συγκεκριμένα, παρουσιάζεται μία υβριδική μορφή εκπαίδευσης, με στοιχεία εξ αποστάσεως μάθησης για την υποστήριξη της αυτονομίας και της ευελιξίας, το οποίο δομείται βάσει του επιπέδου γνωστικών, ανώτερων γνωστικών, μεταγνωστικών ικανοτήτων, καθώς και του βαθμού συνειδητότητας του ατόμου (εννιάβαθμο μοντέλο της χαρισματικότητας). Επιπλέον, η παρούσα έρευνα επικεντρώνεται στη μελέτη και παρουσίαση των δυνατοτήτων ενσωμάτωσης της τεχνητής νοημοσύνης σε διάφορα μαθησιακά περιβάλλοντα, καθώς επίσης παρουσιάζονται οι προοπτικές αξιοποίησης του εννιάβαθμου μοντέλου της χαρισματικότητας για την ανάπτυξη γνωσιακών υπολογιστικών συστημάτων (cognitive computing) με επίκεντρο την υπολογιστική βιωσιμότητα (computational sustainability). Στη συγκεκριμένη έρευνα αναδεικνύεται η δυναμική σχέση μεταξύ των γνωσιακών συστημάτων και των Στόχων 3 & 4 της Βιώσιμης Ανάπτυξης του ΟΗΕ έως το 2030, δηλαδή τον Στόχο της Ποιοτικής Εκπαίδευσης & τον Στόχο της Υγείας και Ευημερίας, αντίστοιχα. Επιπλέον, στο πλαίσιο πραγματοποίησης της παρούσας διατριβής αναπτύχθηκε διαλογικός πράκτορας που προωθεί μεθοδολογίες και τεχνικές γνωσιακής ενίσχυσης με τη μορφή δομημένων ενοτήτων (modules). Ο εν λόγω πράκτορας συνδυάζει χαρακτηριστικά όπως επεξεργασία και κατανόηση φυσικής γλώσσας, μετατροπή κειμένου σε ομιλία & το αντίστροφο, επεκτασιμότητα, διαλειτουργικότητα και άμεση αλληλεπίδραση, ενισχύοντας το κίνητρο για τη χρήση του εργαλείου, καθώς και την αποτελεσματικότητά του. Επιπλέον, οι ενότητες και η διάρθρωσή τους συντελούν στην επίγνωση, από πλευράς του χρήστη, της προστιθέμενης αξίας του εργαλείου για τη δημόσια υγεία, την ποιοτική εκπαίδευση και τη δια βίου μάθηση, καθώς και τη βιώσιμη ανάπτυξη. Συμπερασματικά, η αυτεπίγνωση και η ενσυνειδητότητα αντιπροσωπεύουν ένα ανώτερο νοητικό επίπεδο, το οποίο συνδυάζεται με τις γνωστικές και μεταγνωστικές δεξιότητες του ατόμου, επίπεδο το οποίο, εφόσον κατακτηθεί, συνδυάζεται με την επίτευξη της αειφορίας σε τρία επίπεδα: της προσωπικής, περιβαλλοντικής και κοινωνικής.
Review of contemporary sewage sludge treatment and management methods in European countries with an emphasis on Greece
Authors: ELEFTHERIADOU AIKATERINI , Akratos Christos , Vavatsikos Athanasios , Gratziou Maria Evridiki
Published: June 2024

Municipal sewage sludge is an acute problem in both developed and developing countries. Researchers are conducting many experiments to solve this problem. There are many methods of disposal, neutralization, or reuse of sediments after neutralization. The review of contemporary sewage sludge treatment and management methods in European countries with an emphasis on Greece will provide more information about the most appropriate choice for the use of sewage sludge in Greece.
The difficulties associated with adapting sewage sludge management to the requirements of sustainable development are discussed. The article draws information from the publication of Official Gazette 2692/B/21-04-2023 as well as the projects currently implemented in Greece regarding the treatment of sludge in Urban Wastewater Treatment Units. The forecasts and directions of processing sewage sludge in Greece are also investigated, through the inspection of the commitments and forecasts of the National Waste Management Plan 2015, compared to the new/ updated National Waste Management Plan of 2020.
 In Greece after the introduction of the project "Treatment and purification of urban wastewater in environmentally sensitive settlements and modernization of facilities" of the Recovery and Resilience Fund from 17/01/2023, there is a growing trend towards thermal treatment of sludge using drying methods (solar etc. etc.) which by 2025 will have reformed the facts of the disposal of treated sludge in Greece. However, the examination of the issue of managing the sludge produced by municipal urban waste treatment units and the choice of the appropriate strategy for the management of urban sewage sludge remains a complex problem.
Case Report: A case of metastasis to branchial cleft cyst from papillary thyroid cancer
Authors: Shelar Sheetal , Gupta Roohi , Dhande Rajasbala , Parihar P. H.
Published: June 2024

Branchial cleft cysts are frequently encountered congenital anomalies, arising from the first to fourth pharyngeal clefts and second branchial cleft anomalies are the most common. These anomalies, even though present from birth, become symptomatic only later in life. Majority of them are benign in nature. However, these cysts can get secondarily infected or can harbour secondary metastases and sometimes even primary malignancy in very rare cases. Here we discuss a case of a middle-aged female presenting with a gradually increasing branchial cleft cyst with incidental thyroid lesion on ultrasonography, later proven to be papillary thyroid carcinoma with metastatic spread to the brachial cleft cyst.
Comparison of speed and power of soccer players before the preparation period and during the soccer season
Authors: Miłek Mariusz , Perkowski Radosław
Published: June 2024

Introduction. The article discusses the importance of speed and power in football and the need for appropriate training and load monitoring to minimise risk of injury. A comparative analysis of the players' speed and power indicators before and during the season was presented, suggesting the importance of dynamic physical adaptations in the face of the demands of the competition. Aim. The aim of the study was to investigate whether soccer players could improve their speed and strength through soccer training in a relatively short preparation period. Material and methods. The study involved 41 adult male footballers from the IV and III leagues, aged between 18 and 34, undergoing speed and power assessments. Speed was measured over a distance of 20 metres with additional measurements at 5 and 10 metres, while power was assessed by a long jump from a standing position, taking into account the stability of the landing. Results. Statistical analysis showed no significant differences in speed at 5 and 10 metres between terms I and II, but significant differences were observed in speed at 20 metres, where the average time decreased by 0.04 seconds. In contrast, the power test showed significant differences, increasing by 2.85 W in term II. There were no significant differences in speed and power relative to field position or correlation with age, although a weak positive correlation was observed between age and speed for 20 metres in term II and a weak negative correlation between age and the difference in the power test between terms. Conclusion. The analysis showed significant differences in power tests between terms, as well as differences in speed at 20 metres between defensive and offensive players. There were no significant correlations of age with test results, but a weak positive correlation was observed between age and speed at 20 metres in the 2nd term and a weak negative correlation between age and differences in the power test between terms.
Assessment of physical fitness of young rugby players of the club „MKS Ogniwo Sopot" after a year of systematic training
Authors: Półtoranos Martyna , Perkowski Radosław
Published: June 2024

Introduction: The aim of the study was to assess the physical fitness of young players from the club "MKS Ogniwo Sopot" after a year of systematic training and to evaluate the components of physical fitness supporting the motor performance of young rugby players. Overall balance, responsiveness, coordination, running speed and agility, and endurance were assessed to align with selected EUROFIT tests.
Results: Thirteen players took part in the study. Physical fitness was tested by using five EUROFIT tests. Statistically significant differences were found in the results of the following tests: Plate Tapping test, Standing Long Jump test, 10 x 5 m Shuttle test, Beep test. The only test with a statistically insignificant difference was the Flamingo Balance test.
Conclusion: Analyzing the presented research results, it can be concluded that the athletes obtained higher results than in the previous year, indicating the development of physical fitness components that support the motor achievements their. Physical fitness depends on these components, so we can conclude that an annual period of systematic training has had a positive effect on the physical fitness of young athletes.
The impact of physical exertion on the level of back pain
Authors: Kamińska Natalia , Perkowski Radosław
Published: June 2024

Introduction: Physical activity is an inherent factor in a healthy lifestyle.  Regular exercise allows you to maintain fitness with age and allows for proper functioning of everyday life.  The aim of the study was to assess the impact of physical effort on the level of back pain.
Materials and methods: The study involved 113 people who were assigned to one of two groups using online surveys, taking into account the level of physical activity.  The occurrence of pain was assessed on the basis of the author's questionnaire and Oswestry questionnaire.
Results: The subjects from group 2 do not undertake regular physical exercise and more often indicated the occurrence of spine pain.  Group 1 showed a statistically significant lower risk of pain than group 2. On the basis of the Oswestry questionnaire, group 2 people are significantly more likely to be less able to perform daily activities than group 1 people.
Conclusions: In people undertaking regular physical exercise, less reported pain and lower risk of their occurrence compared to group 2. The group of non-training people show less ability to perform daily activities due to pain.
Weak Kleene Logic and Topic-Sensitive Logics
Authors: CIUNI ROBERTO
Published: June 2024

This paper makes first steps toward a systematic investigation of how pertinence to topic contributes to determine deductively valid reasoning along with preservation of designated values. I start from the interpretation of Weak Kleene Logic WKL as a reasoning tool that preserves truth and topic pertinence, which is offered by Jc Beall. I keep Beall’s motivations and I argue that WKL cannot meet them in a satisfying way. In light of this, I propose an informal definition of a topic-sensitive logic and I proceed to turn it into a formal one by deploying the topic-algebraic framework from the Topic-Sensitive Intentional Modalities project by Francesco Berto. I apply the framework in order to define semantically a ‘classical topic-sensitive logic’ CTSL that meets Beall’s motivations and proves topic-sensitive. Then, I prove results that connect CTSL and any possible topic-sensitive logic to the tradition of containment logics and provide a unification tool for a wide range of recent proposals in philosophical logic. A topic-theoretical interpretation of WKL is then offered without prejudice to the fact that the logic is not topic-sensitive. Finally, the paper discusses some conceptual issues and research perspectives.
ANÁLISE HISTÓRICA DA AFIRMAÇÃO DA IDENTIDADE NEGRA E DAS COTAS RACIAIS NO CEARÁ (1955-2021)
Authors: Santos Arilson dos
Published: June 2024

As Ações Afirmativas constituem-se como políticas públicas de prazo temporário para grupos que tiveram a sua trajetória de direitos (simbólicos e materiais) historicamente prejudicada (SILVA; SILVEIRO, 2003; MUNANGA, 2003). Ademais, essas políticas encontram nas “cotas” uma possibilidade de inclusão específica por meio de vagas direcionadas a determinados segmentos discriminados, visando ao seu ingresso em instituições públicas e privadas, sejam de cunho étnico-raciais, de classe, de gênero entre outros. Por meio da análise do discurso e da interpretação de imagens registradas em impressos jornalísticos, o trabalho busca refletir sobre o silenciamento histórico da identidade negra no Ceará, assim como trazer elementos para se problematizar os desafios para a efetivação das cotas raciais no estado. O estudo conclui que o procedimento de heteroidentificação instituído por demanda dos movimentos sociais possibilitam, além da afirmação identitária, a educação das relações étnico-raciais no Ceará.
QUILOMBAGEM E PRÁXIS NEGRA: ANTIRRACISMO E PROTAGONISMO NEGRO NA OBRA DE CLÓVIS MOURA.
Authors: Francisca da Silva Wanessa Horrana
Published: June 2024

Este artigo tem como objetivo analisar como o intelectual negro, Clóvis Steiger de Assis Moura (1925-2003), constrói sua tese sobre a participação ativa e dinâmica do negro brasileiro no processo de abolição e construção da formação nacional. Intelectual orgânico, Moura produziu ao longo de suas pesquisas, o que podemos chamar de práxis negra, em outras palavras, isso significa que teoria e prática política nunca estiveram separadas em sua obra e sua vida. Ao teorizar que o fim da escravidão está ligado diretamente a Quilombagem, ele inaugura uma historiografia diferente da eurocêntrica, contribuindo significantemente para os estudos das relações raciais no Brasil. Para fundamentar análises e reflexões, será utilizada os textos de Rebeliões da senzala: quilombos, insurreições, guerrilhas (1959), Sociologia do negro brasileiro (1988) e História do Negro Brasileiro (1989), destacando o antirracismo da sua obra.
TRILHANDO A HISTÓRIA INTELECTUAL: UM MAPEAMENTO DAS PRODUÇÕES CIENTÍFICAS DE AMÍLCAR CABRAL E ANÁLISE DE SUAS PRIMEIRAS BIOGRAFIAS
Authors: Velho Delcano Rubilson , Salem dos Santos Silva Milca
Published: June 2024

Amílcar Cabral, destacado intelectual, líder político e teórico revolucionário, desempenhou um papel crucial nas lutas pela independência na África, notadamente nas colônias portuguesas. Nascido em 1924 na Guiné-Bissau, emergiu como figura central no movimento de libertação africano no século XX. Reconhecido por sua eloquência, visão política e compromisso social, Cabral tornou-se o arquiteto intelectual da luta pela liberdade em Guiné-Bissau e Cabo Verde. Sua teoria inovadora da "luta de classes aplicada à realidade colonial" influenciou movimentos de libertação e a teoria política contemporânea. Este artigo propõe um mapeamento abrangente das produções científicas dedicadas a Amílcar Cabral, visando compreender seu legado intelectual e impacto na história e pensamento político africanos, incluindo uma análise aprofundada de suas primeiras biografias e como estas contribuíram para a construção da narrativa sobre sua vida e obra.
ESCREVIVÊNCIAS DE DORA BERTULIO NA CONSOLIDAÇÃO DO QUILOMBO JURÍDICO DIREITO E RELAÇÕES RACIAIS
Authors: De Souza Cidade de Jesus Edmo
Published: June 2024

O presente artigo, que deriva de pesquisa de mestrado realizada perante o programa de pós-graduação em Direito da Universidade Federal de Santa Catarina, pretende visibilizar as formas de atuação e as contribuições intelectuais da jurista Dora Lucia de Lima Bertulio para a sedimentação do quilombo jurídico Direito e Relações Raciais, responsável pela inclusão do debate racial no âmbito das ciências jurídicas. Para tanto, utilizam-se, metodologicamente, entrevista aberta de história de vida e consultas ao acervo bibliográfico relativo à temática, com o fim de demonstrar o quanto a atuação, as produções e o legado dessa intelectual negra desestabilizaram o pensamento jurídico brasileiro hegemônico.
Pressure ulcer development in patients treated for acute ischaemic stroke
Authors: Cicek Esin Derin , Alkan Ayper Önal , Yukselen Nihan Parasiz , Onal Yılmaz , Karakas Hakki Muammer , Vural Ahmet
Published: June 2024

Objective:

The aim of this study was to determine the incidence of pressure ulcers (PUs) in patients treated for acute ischaemic stroke (AIS) and to evaluate comorbid/confounding factors.

Method:

The study included patients treated for AIS who were divided into three treatment groups: those receiving intravenous tissue plasminogen activator therapy (tPA); patients receiving mechanical thrombectomy (MT); and those receiving both tPA and MT. PUs were classified according to the international classification system and factors that may influence their development were investigated.

Results:

A total of 242 patients were included in this study. The incidence of PUs in patients treated for AIS was 7.4%. Most PUs were located on the sacrum (3.7%), followed by the gluteus (3.3%) and trochanter (2.9%). With regards to PU classification: 29% were stage I; 34% were stage II; and the remainder were stage III. Age was not a significant factor in the development of PUs (p=0.172). Patients in the tPA group had a lower PU incidence (2.3%) than patients in the tPA+MT group (15.7%) and MT group (12.1%) (p=0.001). Patients with PUs had a longer period of hospitalisation (18.5±11.92 days) than patients without a PU (8.0±8.52 days) (p=0.000). National Institute of Health Stroke Scale (NIHSS) scores at admission were higher in patients with PUs than in patients without a PU (14.33±4.38 versus 11.08±5.68, respectively; p=0.010). The difference in presence of comorbidities between patients with and without PUs (p=0.922) and between treatment groups (p=0.677) were not statistically significant. The incidence of PUs was higher in patients requiring intensive care, but this difference was not statistically significant (p=0.089).

Conclusion:

In this study, patients treated for AIS with high NIHSS scores at admission and/or receiving MT were at higher risk for PUs, and so particular attention should be given to these patients in order to prevent PU development.
Dehydrated Amnion Chorion Membrane versus standard of care for diabetic foot ulcers: a randomised controlled trial
Authors: Cazzell Shawn M , Caporusso Joseph , Vayser Dean , Davis R Daniel , Alvarez Oscar M , Sabolinski Michael L
Published: June 2024

Objective:

Diabetic foot ulcers (DFUs) continue to challenge wound care practitioners. This prospective, multicentre, randomised controlled trial (RCT) evaluated the effectiveness of a dehydrated Amnion Chorion Membrane (dACM) (Organogenesis Inc., US) versus standard of care (SoC) alone in complex DFUs in a challenging patient population.

Method:

Subjects with a DFU extending into dermis, subcutaneous tissue, tendon, capsule, bone or joint were enrolled in a 12-week trial. They were allocated equally to two treatment groups: dACM (plus SoC); or SoC alone. The primary endpoint was frequency of wound closure determined by a Cox analysis that adjusted for duration and wound area. Kaplan–Meier analysis was used to determine median time to complete wound closure (CWC).

Results:

The cohort comprised 218 patients, and these were split equally between the two treatment groups with 109 patients in each. A Cox analysis showed that the estimated frequency of wound closure for the dACM plus SoC group was statistically superior to the SoC alone group at week 4 (12% versus 8%), week 6 (22% versus 11%), week 8 (31% versus 21%), week 10 (42% versus 27%) and week 12 (50% versus 35%), respectively (p=0.04). The computed hazard ratio (1.48 (confidence interval: 0.95, 2.29) showed a 48% greater probability of wound closure in favour of the dACM group. Median time to wound closure for dACM-treated ulcers was 84 days compared to ‘not achieved’ in the SoC-treated group (i.e., ≥50% of SoC-treated DFUs failed to heal by week 12; p=0.04).

Conclusion:

In an adequately powered DFU RCT, dACM increased the frequency, decreased the median time, and improved the probability of CWC when compared with SoC alone. dACM demonstrated beneficial effects in DFUs in a complex patient population.

Declaration of interest:

This study was funded by Organogenesis Inc., US. JC serves as a consultant and speaker for Organogenesis. RDD serves as a speaker for Organogenesis. OMA and MLS serve as consultants for Organogenesis. The authors have no other conflicts of interest to declare.
Fabrication of Silver Nanoparticles Using Acalypha paniculata Extract, AI-Based Interaction Analysis and Its Activity Explication
Authors:   Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science and Technology, GST Road, Vandalur, Chennai, Tamilnadu, India-600048., A. Elumalai , Navabshan Irfan ,   Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science and Technology, GST Road, Vandalur, Chennai, Tamilnadu, India-600048.
Published: June 2024

This study showcases eco-friendly silver nanoparticle synthesis using Acalypha paniculata herb and its biological activity. Artificial Intelligence (AI) tools are used to analyze the interaction between phytoconstituent and silver ion to find the capping and nanoparticle fabricating phytoconstituents. Ethanolic extract was added to silver nitrate solution and irradiated under sunlight until the formation of silver nanoparticles. These particles were sedimented, characterised by spectral technique and biological activity was measured. Finally, a Computational simulation algorithm was used to visualize the interactions of phytoconstituent and silver nanoparticles. Ultra Violet (UV)-visible spectrum revealed a visible peak at 420nm in the brownish solution, Dynamic Light Scattering (DLS) size of 54.7nm, spherical crystalline morphology of the nanoparticle by Transmission Electron Microscope (TEM) and X-Ray Diffraction (XRD) analysis. The synthesized silver nanoparticle antagonised Escherichia coli, and Bacillus cereus and showed the Minimum Inhibitory Concentration (MIC) of 65 µg/mL, and 78 µg/mL respectively and Minimum Bacterial Concentration (MBC) of 52.5 µg/mL for B.cereus and 61.5µg/mL for E.coli. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radicals IC50 was found to be 97.414 µg/mL and it revealed the dose-dependent antioxidant activity of phyto-capped silver particles. The cytotoxicity of fabricated nanoparticles was studied on Vero cells and the results indicate that IC50 of 47.28 µg/mL. Furthermore, an AI-based study concludes that Alloaromadendrene adsorbed highly by the Silver (Ag) ion compared to the nitrate with an affinity of -30.6755 kcal/mol. This research introduces an innovative, cost-effective method for stable Acalypha paniculata Silver Nanoparticles (AP-AgNPs) fabrication, crucial for diverse biomedical uses.
Star-Tooth Spherical Disc Closing Wheels for a Row Crop Planter: Experiment and Discrete Element Method Modeling
Authors: Lu Qi , Liu Li-Jing , Liu Zhong-Jun , Zhou Jun-Ping
Published: June 2024

Highlights

Star-tooth spherical disc closing wheels for a row crop planter are proposed.

A discrete element interaction model between the furrow soil and the closing wheels was established.

The operational performances of the closing wheels under different operating conditions were analyzed based on discrete element simulation and soil bin tests.

Abstract. Traditional row crop planter closing wheel systems are sometimes unreliable, causing inadequate seed-soil contact, thereby reducing seed germination and emergence. To solve this problem, a star-tooth spherical disc closing wheel system is proposed. To further explore the operational mechanism of the closing wheels, a discrete element interaction model between the furrow soil and the closing wheels was established, and the operation process of the closing wheels was analyzed. A single factor test was designed with forward speed, disc tilt angle, disc lateral distance, and disc penetration depth as the test factors. Based on simulation tests and soil bin tests, the effects of the velocity and displacement of soil aggregates, closing wheel draft, and operational quality under different test conditions were explored. The test results showed that properly increasing the forward speed, disc tilt angle, and disc penetration depth, and selecting the appropriate lateral distance between the rotation centers of the two discs can increase the trend of soil aggregates moving towards the furrow, increase the weight of the covering soil, improve the uniformity of soil covering, facilitate the closure of the seed furrow, and improve the quality of operation. The Discrete Element Method (DEM) can accurately simulate operational quality in the soil covering process. The operational quality of the closing wheels can be explained by the movement of the soil aggregates. These results provide theoretical support for the performance of closing wheel systems. Keywords: Closing wheel system, Discrete element method, Mechanism research, Simulation.
Uniformity of Campus Design and Conventionality of Student Culture: Explorations of Person–Environment Interaction
Authors: Murray Joseph L. , Baldwin Schauer Elizabeth , Burghoff Brown Chelsea , Troxell Grill Alexandra
Published: June 2024

Abstract: Campus maps and architectural images from institutional websites were used to compare 45 collegiate institutions cited in prior literature as manifesting traits of either conventional or nonconformist student cultures. Based on person–environment interaction theory, it was anticipated that the physical traits of campuses associated with conventional student cultures would be more uniform than those of campuses associated with nonconformist student cultures. Nonparametric tests revealed significant differences in the anticipated direction on three of six aspects of architectural design (i.e., color, roofline, and ornamentation). Differences in uniformity of campus layout were in the anticipated direction but fell slightly short of statistical significance.
Performing Sphagnum: Ecological Ethics in Cryptic’s Below the Blanket
Authors: Spalink Angenette
Published: June 2024

Abstract: Below the Blanket (2019), a performance installation at the Royal Botanic Garden Edinburgh, staged the enmeshed multispecies relationships present in the Flow Country, the largest blanket bog system in the world. While Below the Blanket represented the Flow Country through various artistic mediums, the physical matter—the sphagnum and peat mosses—that comprises the bog was conspicuously absent. Using critical plant theory, ecodramaturgies, and performance theory, this article grapples with the ethics of staging ecological matter such as mosses within the colonial contexts of the botanic garden and provides insights into the complex ethics of ecological performance.
Mode-locking and wavelength-tuning of a NPR fiber laser based on optical speckle
Authors: Pu Yongjie , Fan Minyu , Shen Qihao , Guo Pan , Gao Yuan , Wang Sha
Published: June 2024

Passively mode-locked fiber lasers based on nonlinear polarization rotation (NPR) have been widely used due to their ability to produce short pulses with high peak power. Nevertheless, environmental perturbations can influence the mode-locked state, making it a challenge for the practical implementation. Therefore, researchers are searching for assessment criteria to quickly assist and maintain mode-locking of NPR fiber lasers. Speckle patterns containing spectral information can be generated when the laser transmits through a scattering medium, which can serve as indicators of the mode-locked state. The mode-locked regions are confined to the area close to the minimum texture contrast of speckle patterns. Based on these characteristics, we manually simulate the automatic mode-locking (AML). In addition, we utilize convolutional neural networks (CNNs) to recognize speckle patterns of wavelength tunable lasers and determine the center wavelength.
Using empirical dynamic modeling to identify the impact of meteorological factors on hemorrhagic fever with renal syndrome in Weifang, Northeastern China, from 2011 to 2020
Authors: Zheng Liang , Gao Qi , Yu Shengnan , Chen Yijin , Shi Yuan , Sun Minghao , Liu Ying , Wang Zhiqiang , Li Xiujun
Published: June 2024

Background

Hemorrhagic Fever with Renal Syndrome (HFRS) continues to pose a significant public health threat to the well-being of the population. Given that the spread of HFRS is susceptible to meteorological factors, we aim to probe into the meteorological drivers of HFRS. Thus, novel techniques that can discern time-delayed non-linear relationships from nonlinear dynamical systems are compulsory.

Methods

We analyze the epidemiological features of HFRS in Weifang City, 2011–2020, via the employment of the Empirical Dynamic Modeling (EDM) method. Our analysis delves into the intricate web of time-delayed non-linear associations between meteorological factors and HFRS. Additionally, we investigate the repercussions of minor perturbations in meteorological variables on future HFRS incidence.

Results

A total of 2515 HFRS cases were reported in Weifang from 2011 to 2020. The number of cases per week was 4.81, and the average weekly incidence was 0.52 per 1,000,000. The propagation of HFRS is significantly impacted by the mean weekly temperature, relative humidity, cumulative rainfall, and wind speed, and the ρCCM converges to 0.55,0.48,0.38 and 0.39, respectively.

The graphical representation of the relationship between temperature (lagged by 2 weeks) and the incidence of HFRS exhibits an inverted U-shaped curve, whereby the incidence of HFRS culminates as the temperature reaches 10 °C. Moreover, temperature, relative humidity, cumulative rainfall, and wind speed exhibit a positive correlation with HFRS incidence, with a time lag of 4–6 months.

Conclusions

Our discoveries suggest that meteorological factors can drive the transmission of HFRS both at a macroscopic and microscopic scale. Prospective alterations in meteorological conditions, for instance, elevations in temperature, relative humidity, and precipitation will instigate an upsurge in the incidence of HFRS after 4–6 months, and thus, timely public health measures should be taken to mitigate these changes.
A randomized controlled safety and feasibility trial of floatation-REST in anxious and depressed individuals
Authors: Garland McKenna M. , Wilson Raminta , Thompson Wesley K. , Stein Murray B. , Paulus Martin P. , Feinstein Justin S. , Khalsa Sahib S.
Published: June 2024

Background

Reduced Environmental Stimulation Therapy via floatation (floatation-REST) is a behavioral intervention designed to attenuate exteroceptive sensory input to the nervous system. Prior studies in anxious and depressed individuals demonstrated that single sessions of floatation-REST are safe, well-tolerated, and associated with an acute anxiolytic and antidepressant effect that persists for over 48 hours. However, the feasibility of using floatation-REST as a repeated intervention in anxious and depressed populations has not been well-investigated.

Methods

In this single-blind safety and feasibility trial, 75 individuals with anxiety and depression were randomized to complete six sessions of floatation-REST in different formats: pool-REST (weekly 1-hour float sessions), pool-REST preferred (float sessions with flexibility of duration and frequency), or an active comparator (chair-REST; weekly 1-hour sessions in a Zero Gravity chair). Feasibility (primary outcome) was assessed via an 80% rate of adherence to the assigned intervention; tolerability via study dropout and duration/frequency of REST utilization; and safety via incidence of adverse events and ratings about the effects of REST.

Results

Of 1,715 individuals initially screened, 75 participants were ultimately randomized. Six-session adherence was 85% for pool-REST (mean, M = 5.1 sessions; standard deviation, SD = 1.8), 89% for pool-REST preferred (M = 5.3 sessions; SD = 1.6), and 74% for chair-REST (M = 4.4 sessions; SD = 2.5). Dropout rates at the end of the intervention did not differ significantly between the treatment conditions. Mean session durations were 53.0 minutes (SD = 12.3) for pool-REST, 75.4 minutes (SD = 29.4) for pool-REST preferred, and 58.4 minutes (SD = 4.3) for chair-REST. There were no serious adverse events associated with any intervention. Positive experiences were endorsed more commonly than negative ones and were also rated at higher levels of intensity.

Conclusions

Six sessions of floatation-REST appear feasible, well-tolerated, and safe in anxious and depressed individuals. Floatation-REST induces positively-valenced experiences with few negative effects. Larger randomized controlled trials evaluating markers of clinical efficacy are warranted.

Clinical Trial Registration Identifier

NCT03899090.