bluuebunny/crossref_metadata_2025 huggingface dataset:
The Most Significant Surgical Risk Factors of Giant Intracranial Meningiomas: Localization Matters Much More than Grading and Volume of Peritumoral Brain Edema. A Retrospective Clinical Neuroradiological and Immunohistochemical Study
Authors: Armocida Daniele , Bevacqua Giuseppina , Catapano Antonia , Palmieri Mauro , Arcidiacono Umberto Aldo , Pesce Alessandro , Cofano Fabio , Picotti Veronica , Salvati Maurizio , Garbossa Diego , D'Andrea Giancarlo , Santoro Antonio , Frati Alessandro
Published: November 2021

Background: Giant intracranial meningiomas (GIMs) are extremely rare and are usually considered arduous to resect totally with poorer prognosis. The real mechanisms by which a meningioma can grow to be defined as "giant" are unknown, as well as the real biological , radiological profile and the different outcomes.Methods: We performed a retrospective review of a consecutive series of surgically-treated patients suffering from intracranial Meningioma. All the patients were assigned on the ground of the preoperative imaging to the Giant and Medium/Large Meningiomas. We investigated whether the presence large diameter on radiological diagnosis is indicative for different mortality rate, grading, characteristic and clinical/neurological outcome.Results: The study shows that surgically treated giant meningiomas have a higher risk of developing complications in the postoperative phase (Chi square= 11.121, dF=1, p=0.001). The direct proportional relationship between peritumoral brain edema (PBE) volume and tumor volume was present only in the medium/large group and was not present in the giant meningioma group. When comparing the degree of performance there is a statistically significant difference between localization and KPS immediately postoperatively (p=0.04) particularly for sphenopetroclival meningiomas (p=0.071), and partially with GIM of the olfactory groove with arterial encasement. The most frequently encountered complications include the occurrence of ischemia (p=0.049), infection (p=0.03), and the occurrence of postoperative seizures.Conclusions: We identified that the major surgical risk factor for GIMs is location, where the petro-clival region and, to a lesser extent the anterior basicranium offer a greater risk of neurovascular involvement and arterial encasement. On other hand, the risk correlated with PBE is poorer in GIM although there is a well-noted correlation between the Edema volume and outcome in meningiomas.
Associations Between Short-Term Ambient Particulate Matter Exposure and The Risk of Severe COVID-19
Authors: Li Zhong-Qi , Tao Bi-Lin , Zhan Meng-Yao , Hu Zhi-Liang , Yi Yong-Xiang , Wang Jian-Ming
Published: November 2021

Background

Previous studies have suggested the relation between outdoor air pollution and the onset risk of Corona Virus Disease 2019 (COVID-19). However, there is a lack of data related to the severity of the disease, especially in China.
Methods

We recruited a group of COVID-19 patients diagnosed in a recent large-scale outbreak caused by Delta variants in eastern China. We collected ambient air pollution data of the same period where the case occurred and applied a generalized linear model (GLM) to analyze the effects of short-term outdoor ambient particulate matter (PM) exposure on the risk of severe COVID-19.
Results

A total of 476 confirmed adult patients were recruited, of which 42 (8.82%) had a severe illness. With a unit increase in PM10, the risk of severe COVID-19 increased by 47.64% (95% confidence interval [CI]: 27.67, 70.73) at lag 0-14 days, 65.00% (95% CI: 35.18, 101.40) at lag 0-21 days, and 69.44% (95% CI: 37.03, 109.50) at lag 0-28 days, respectively. The association remained significant at lag 0-14 days or 0-28 days in the multi-pollutant models. With a unit increase in PM2.5, the risk of severe COVID-19 increased by 49.47% (95% CI: 19.61, 86.78) at lag 0-14 days, 97.61% (95% CI: 45.92, 167.60) at lag 0-21 days, and 120.27% (95% CI: 56.53, 209.98) at lag 0-28 days, respectively. The association remained significant at lag 0-21 days or 0-28 days in the multi-pollutant models.
Conclusions

Our results indicated that short-term exposure to outdoor PM was positively related to the risk of severe COVID-19, and reducing air pollution may contribute to the control of COVID-19.
An Efficient SMOTE Based Machine Learning classification for Prediction & Detection of PCOS
Authors: Dutta Pijush , Paul Shobhandeb , Majumder Madhurima
Published: November 2021

Polycystic ovary syndrome (PCOS) is a well known catabolism based and reproductive endocrinopathies disease which affects up to 18% of women in reproductive age. PCOS results irregularity in menstrual periods which might directed to numerous entanglements such as embodiment of cysts (follicles) in either or both ovaries as well as impotence for giving birth, turmoil in androgen levels, increased BMI and some other deviancy in hormone level of LH, FSH, DHEAS, Fasting insulin and Fasting blood sugar. Detection & prevention of this disease as early as possible it has attracted research attention. Overall research in this therapeutic unhealthiness categorisation using machine learning technique is considered less to some extent because of data imbalance. In this research we can make a lay on the line for a novel forecast model using Synthetic Minority Oversampling Technique (SMOTE) with five machine learning algorithms like Logistic Regression, Random Forest, Decision Tree Support vector machine and K-Nearest Neighbor (KNN) model which automates the PCOS detection in an early stage. The framework of the recommended classification of PCOS is comprised of three different layers. The first flapping which is responsible for handling the missing values & oversampling the splinter class in datasets. In second layer, the most eloquent attributes are tabbed using Principal component analysis (PCA). In third layer, the projected model is skilled & its efficiency is reckoned in a fourth layer in terms of classification accuracy, Training time (TT), F1 score, Recall (Sensitivity), Precision & Area under the ROC (AUROC). The propounded algorithm clarify the outperformed of its corresponded & achieves the preeminent accuracy, precision, F1 score, Sensitivity, training time & AUROC. The best model achieve accuracy, Training time (TT), F1 score, Recall (Sensitivity), Precision & Area under the ROC (AUROC) is 97.11%, 0.010 sec, 98%, 98%, 98% & 95.6% respectively.
The Intellectual Assets in Europe
Authors: Alberto Costantiello , Lucio Laureti , Angelo Leogrande
Published: November 2021

In this article we investigate the determinants of the Intellectual Assets in Europe. We use data from the European Innovation Scoreboard of the European Commission in the period 2000-2019 for 36 countries. Data are analyzed using Panel with Fixed Effects, Random Effects, WLS, Pooled OLS, Dynamic Panel at 1 Stage. Results show that the presence of Intellectual Assets in Europe is positively associated with “Enterprise Births”, “Top R&D Spending Enterprises per 10 mln Population”, “Employment Share Manufacturing”, “Share High and Medium high-tech Manufacturing”, “Attractive Research Systems”, “Finance and Support”, “Innovators”, “Sales Impact” and is negatively associated to “Government Procurement of Advanced Technology Products” and “Share Knowledge-Intensive Services”
Advanced Tracing Methods for Container Messaging Systems Analysis
Authors: DENYS Pierre-Frédérick , Dagenais Michel R. , Pepin Martin
Published: November 2021

Containers are increasingly used for software deployment, because of the modularity they offer for packagingand isolating applications. However, this implies a reliable communication system between computing elementsin different containers. Thence, conventional messaging systems have evolved and adapted to increasing loadsand Edge Computing. Inter-container communications, with Message Oriented Middleware, provide insight intothe execution of distributed applications, as well as a deeper input for analysis. However detecting messagelosses and slowdowns on this type of infrastructure is a challenge. Actual tracing solutions for this task werecompared to identify shortcomings and possible improvements. New tracing methods are proposed to addressthese shortcomings and open the door to more versatile tracing tools. This paper focuses on the approachestaken to extract information from messages, and achieve advanced analysis. Two new methods are presented,each providing a detailed picture of the distributed system, while being better suited for different use cases,depending on the environmental constraints.
The frequency of bacterial pathogens of mastitis and their antibiotic susceptibility in Saanen and Alpine goats
Authors: Esmaeili Hossein , Shakeri Amir Pasha , Tajik Parviz , Hamedi Mona
Published: November 2021

Mastitis is mammary gland inflammation and as the purpose of Saanen and Alpine farms is milk production, control of mastitis is important. Antimicrobial resistance among mastitis pathogens has gradually been increasing. The aim of the present study was to isolate pathogenic bacteria from mastitis cases in Saanen and Alpine goats and to determine their antibiotic resistance in milk. The milk sample of 26 Saanen and 29 Alpine breeds with clinical mastitis was collected and cultured on general microbiological media. Then, the colonies were stained by gram staining and were assessed by differential media and biochemical tests. PCR was performed for the detection of Mycoplasma spp. The isolated bacteria were tested against 12 antibacterial disks. The significant difference in drug resistance levels between the Saanen and Alpine breeds was statistically assessed. Mycoplasma spp. was detected in 12.73% of samples. The frequency of the isolated bacteria was Escherichia coli (29.1%), Trueperella pyogenes (25.5%), Staphylococcus aureus (16.4%), Streptococcus agalactiae (9.1%), coagulase negative staphylococci (5.5%), and Corynebacterium pseudotuberculosis (1.8%) respectively. The significant difference between Saanen and Alpine was observed in antibiotic resistance to amoxicillin which showed more resistance in the Alpine breed. All the isolated bacteria showed multidrug resistance. Based on the obtained data using of antibiotics more accurate and using antibiogram test by clinician is necessary in the treatment of mastitis.
Multiomics Combined Analysis of Low-Phosphorus and Drought Stresses in Lotus Japonicus
Authors: Peijie+ Ma , Yajiao+ Li , Jianhong Shu , Ziyuan Wang , Xi Chen , Xiaoli Wang
Published: November 2021

BackgroundLotus japonicus is a perennial herb in Leguminosae. It is a good feed source and improves soil. It is also an excellent honey source and medicinal plant. Low-phosphorus and drought stresses are among the main abiotic stress factors limiting the production of pulse roots. MethodsIn this experiment, the effects of low-phosphorus and drought stresses on Baimai roots were analyzed under three treatments: control (zl1), low-phosphorus stress (zl2) and drought stress (zl3). Results A total of 2176, 3026 and 2980 differentially expressed genes were screened in zl1 vs. zl2, zl1 vs. zl3 and zl2 vs. zl3, respectively. The differentially expressed genes were enriched in functions related to cells, membranes, ion binding, enzyme activity and resistance to low-phosphorus and drought stresses. The enriched KEGG pathways included the MAPK signaling pathway-plant, flavor biosynthesis, starch and sucrose metabolism and plant hormone signal transmission. In particular, a large number of differentially expressed genes were enriched in the response to plant hormone signal transmission pathways among different treatments, and gene expression changes were analyzed. In addition, the differentially expressed genes identified under drought stress and the phase response genes identified under osmotic stress were upregulated. Differential metabolites were mainly enriched in the important metabolic pathways of flavonoid biosynthesis, arginine and proline metabolism and starch and sucrose metabolism. Differentially expressed proteins were mainly enriched in GO terms related to cell, membrane, ion binding and enzyme activity functions, and the main enriched KEGG pathways included the ribosome, starch and sucrose metabolism and plant hormone signal transmission pathways. ConclusionIn conclusion, these results of transcriptome, metabolome and proteome sequencing are helpful for understanding the response mechanisms, gene changes, metabolite changes and protein changes in Baimai roots under low-phosphorus and drought stress conditions to lay a foundation for future research on Lotus japonicus.
Towards Spectral Efficiency Enhancement for IoT Aided Smart Transportation: A Compressive OFDM Transmission and Regularized Recovery Approach
Authors: Zhang Yusi , Li Yong , Fang Xiaojie , Sha Xuejun , Feng Yuqing , Wang Weizhi
Published: November 2021

The increasing number of vehicles brings ubiquitous connectivity and huge information interaction, implementing with limited spectrum resource. Focusing on the higher spectral efficiency requirement, a compressive OFDM system is proposed in this paper. The idea of compressing the transmission of OFDM signal for spectral efficiency enhancement origins from GP extrapolation algorithm for bandlimited signal. In the proposed scheme, a truncation filter with deliberately designed compressed ratio and truncation mode is performed on the OFDM signal to generate the compressive OFDM signal. At the receiver, up-sampling and iterative extrapolation are conducted to recover from the partial signal. Simulation results show that the compressive OFDM signal could be compressed up to 0.5, presenting better compressive capability than the typical nonorthogonal SEFDM system. Further considering the ill-posed problem caused by the noise, a regularization approach is adopted to retain the convergence of recovery. Moreover, the proposed compressive OFDM system possesses the spectrally efficient advantage than SEFDM system. At the compressed ratio 0.5, the compressive OFDM system possesses better BER than SEFDM. At 10dB E b /N 0 , the throughput rate of the compressive OFDM is 2 times and 1.6 times higher than OFDM and SEFDM, respectively.
The importance of improving digital skills in modern language teaching
Authors: Maruntelu Liliana
Published: November 2021

The general framework and general policies for e-learning are legitimated by the strategic objectives of the European Union aimed at increasing the competitiveness of the human resource. Thus, in 2001, the European Employment Guidelines showed the need for member states to adopt coherent strategies for lifelong learning. The European Social Agenda also highlighted the importance of access to lifelong learning for any person, especially in the field of information and communication technologies. This paper is intended to prove that modern languages are among the advantaged disciplines of using ICT, by demonstrating that specific language competencies can interact with ICT key competences, resulting in modern teaching-learning-evaluation activities.
Genetic algorithms - variable size populations of chromosomes. An adaptive approach
Authors: R Maniu
Published: November 2021

The size of the chromosome population is an essential parameter of genetic algorithms. A large population involves a large amount of calculations but provides a complete scroll of the search space and the increased probability of generating a global optimum. A small population size, through the small number of operations required, causes a quick run of the algorithm, with increasing the probability of detecting a local optimum to the detriment of the global one. This paper proposes the use of an adaptive, variable size of chromosome population. We will demonstrate that this approach leads to an acceleration of the algorithm operation, without having a negative impact on the quality of provided solutions.
Packaging Training for Traditional Emping Melinjo Crackers’ Producers in Menes Village, Pandeglang Banten
Authors: Sanjaya Marta
Published: November 2021

Menes village in Pandeglang, Banten has long been known as the largest Emping Melinjo cracker producing area in Indonesia. The production process is carried out using a conventional process with family management, where each head of the family produces small to medium quantities of the cracker and then the middlemen or wholesalers collects them. The Emping producer’s community has some limitation in packaging knowledge and technology that makes them receive only a small profit. We provide a material regarding the good packaging concept to improve the knowledge of community. In addition, the booklet material also equipped with various explanations about marketing strategies to help the community develop products and increase sales. After receiving the booklet material, some feedbacks from participants gathered to find the effectiveness of such method of knowledge delivering.
Pseudomicosis por oportunistas: desconocimiento y retos diagnósticos
Authors: Garcés-Abad María Adelaida , Cardona Castro Nora
Published: November 2021

Se denominan pseudomicosis a las infecciones generadas por microorganismos que parecen hongos pero que no lo son. En esta revisión se abordan desde una perspectiva etiológica, epidemiológica y clínica algunas de las pseudomicosis por oportunistas más frecuentes: actinomicosis, botriomicosis, nocardiosis y prototecosis. Adicionalmente, se revisan las herramientas clínicas y paraclínicas para facilitar su diagnóstico y se actualizan las pautas de tratamiento.
Cardiomiopatía hipertrófica en fase de burnout
Authors: Echavarria Cross Alejandro , Pájaro-Franco Luis Guillermo , Naranjo-Restrepo Sebastián , Sánchez-Présiga Daniela
Published: November 2021

La cardiomiopatía hipertrófica es una entidad de origen genético que se caracteriza por hipertrofia ventricular izquierda en ausencia de otras enfermedades como etiología. Los pacientes suelen ser asintomáticos; sin embargo, el espectro de presentación es amplio pudiéndose encontrar falla cardiaca, obstrucción del tracto de salida, arritmias, muerte súbita y la etapa final o ''burnout''. La valoración morfológica inicial se realiza con ecocardiograma transtorácico, aunque la resonancia magnética cardiaca es el estudio de elección para confirmar el diagnóstico. Presentamos el caso de una mujer de 43 años con antecedente de cardiomiopatía hipertrófica quien había sido intervenida previamente e ingresó al servicio de urgencias de forma descompensada, documentándose progresión a fase “burnout” y su manejo subsecuente. Si bien este fenotipo no es común tiene importantes implicaciones pronósticas y en la calidad de vida. Por lo anterior, un diagnóstico y tratamiento oportuno pueden impactar favorablemente.
Episode from the history of Baltic trade: Import of paper to the Moscow state
Authors:   St. Petersburg State University, Weber Dmitriy Ivanovich , Nosova Ekaterina Igorevna ,   St. Petersburg Institute of History, Russian Academy of Sciences
Published: November 2021

The article is dedicated to one of the episodes of trade in the Baltic region, namely the import of paper into the Moscow state. The emphasis is not on the fact of the availability of European paper based on filigree, but an attempt has been made to consider the ways of supplying this important writing material through written sources. It is known that one of the ports of delivery of paper in earlier modern times was Arkhangelsk, but this article considers the important trade route for the Moscow state as the cities of Livonia. Despite the fact that it is difficult to compare it with, for example, the Lower Rhine or the Netherlands in terms of the amount of paper sold, the Baltic region is the one to which Moscow State was referred. The Hanseatic cities of Riga and Reval were the main paper supply centers throughout the fifteenth century, but the registers of the Zund tax show an increase in Narva’s position. This source, in particular, notes a significant number of ships going to Narva with paper, for example, from Dieppe. A sharp increase in the supply of paper precisely during the period when the city belonged to the Moscow state, during the Livonian War. This suggests that Narva was one of the most important points of French paper deliveries during the reign of Ivan the Terrible.
An innovative synthesis of early medieval Croatian history (On N. Budak’s book «The Croatian history from 550 to 1100»)
Authors:   St. Petersburg State University, Alimov Denis Evgenievich
Published: November 2021

The article is a review of the book by the Croatian historian Neven Budak «Croatian history from 550 to 1100» (Budak, Neven. Hrvatska povijest od 550. do 1100. Zagreb, Leykam international, 2018. 352 р.). Budak’s book is an innovative conceptual synthesis of the early medieval history of Croatia taking full account of the latest achievements in history and archeology. From new theoretical and methodological positions, the book examines the processes of transition from antiquity to the Middle Ages in Dalmatia, Istria, and southern Pannonia, the formation of the Croatian ethnic community, the formation of Croatian polity and the socio-political development of the Croatian kingdom in the 9th–11th centuries. An important feature of the book is that the early medieval Croatian history is examined in it in a wider European context, with great attention to events and processes that took place in Byzantium, the Carolingian Empire, Rome, Venice, the Kingdom of Hungary, etc., which allowed the researcher to adequately interpret the most important events and the processes of the Croatian early Middle Ages. By creating a convenient theoretical framework for the further contextualizing of historical information, the book can serve as a new starting point for research and understanding of the Croatian early Middle Ages.
Interconnection of linguistics and musical art
Authors: Solomonova Olga B. , Zavgorodnia Galyna F. , Muravska Olha V. , Chernoivanenko Alla D. , Aleksandrova Oksana O.
Published: November 2021

The terminology of music semiology, which is an academic discipline with a significant educational resonance and a necessary component of music and educational practice at its higher educational and qualification levels, lies at the intersection of the main aspects of musicology such as the history of music, the theory and analysis of musical forms, music aesthetics and the theory of music interpretation, and others. Music semiology covers the transitional methodological abilities due to its subject reference points and the wide range of the material involved in the cognitive field. Music semiology can be considered a necessary basic discipline for the professional training of musicologists and practicing musicians of any programme. There is no doubt about the importance of mastering the language system, which is fundamental in the chosen field of communication. As an academic discipline, music semiology can be presented according to the way its terminology is built, it includes three main themes among which each of the following continues the meaning of the previous one by deepening and enlarging, detailing in an analytical way. Scientific novelty is determined by the fact that unlike music semiotics and the theory of music semantics.
Contributing Factors to Forest Loss in Conterminous U.S. for the 1990s and 2000s
Authors:   State University of New York College of Environmental Science and Forestry, 1 Forestry Dr., Syracuse, NY, 130210, USA, Mountrakis Giorgos , Yang Sheng ,   State University of New York College of Environmental Science and Forestry, 1 Forestry Dr., Syracuse, NY, 130210, USA
Published: November 2021

While numerous studies have considered forest loss factors at local scales, there is a gap of comparative quantitative regional modeling at the U.S. national level. Here, we investigated statistical relationships between gross forest cover loss (GFCL) and numerous socioeconomic, biophysical and ownership variables between two decades, the 1990s and the 2000s. A spatial error model was employed to compensate for spatial autocorrelation effects. Models from the 2000s had stronger explanatory power than the 1990s models, especially in the Northeast and the South (R2 of 0.89 and 0.87 respectively). The amount of forested areas in low slopes was a highly influential factor for high GFCL, followed by urban area cover and mill density. On the other hand, agricultural cover was negatively correlated with GFCL acting as a stabilizing factor in the South and Midwest regions. Our study offers an important insight in regional drivers of GFCL, drivers that should be further examined in the local context to gather better understanding of their contributions.
Homeopathy in Epidemics: From Cholera to 1918 Spanish Flu (Part 2)
Authors:   Fondazione Negro-Museo di Storia dell’Omeopatia, Roma, Italy, Negro Francesco E. , Marino Francesco V. ,   FIAMO-Federazione Italiana delle Associazioni e dei Medici Omeopati, Roma, Italy
Published: November 2021

The 19th century saw an explosion of serious epidemic diseases, such as smallpox and scarlet fever, which led to the development of an alternative system of medicine called homeopathy. Under this system, S. Hahnemann developed a rigorous methodology based on repeated observations on the field, leading to successful results. The aim of this work is to depict the birth and evolution of his thought. The correct understanding and application of this methodology became the reference model for subsequent generations of homeopaths, who successfully treated some epidemics, such as cholera and Spanish flu. Although these results were well-documented , they were not recognized by the academic community; however, they gave a great impulse to the worldwide spread of homeopathy.
Suicide Risk and Protective Factors in Online Support Forum Posts: Annotation Scheme Development and Validation Study
Authors: Chancellor Stevie , Sumner Steven A , David-Ferdon Corinne , Ahmad Tahirah , De Choudhury Munmun
Published: November 2021

Background

Online communities provide support for individuals looking for help with suicidal ideation and crisis. As community data are increasingly used to devise machine learning models to infer who might be at risk, there have been limited efforts to identify both risk and protective factors in web-based posts. These annotations can enrich and augment computational assessment approaches to identify appropriate intervention points, which are useful to public health professionals and suicide prevention researchers.

Objective

This qualitative study aims to develop a valid and reliable annotation scheme for evaluating risk and protective factors for suicidal ideation in posts in suicide crisis forums.

Methods

We designed a valid, reliable, and clinically grounded process for identifying risk and protective markers in social media data. This scheme draws on prior work on construct validity and the social sciences of measurement. We then applied the scheme to annotate 200 posts from r/SuicideWatch—a Reddit community focused on suicide crisis.

Results

We documented our results on producing an annotation scheme that is consistent with leading public health information coding schemes for suicide and advances attention to protective factors. Our study showed high internal validity, and we have presented results that indicate that our approach is consistent with findings from prior work.

Conclusions

Our work formalizes a framework that incorporates construct validity into the development of annotation schemes for suicide risk on social media. This study furthers the understanding of risk and protective factors expressed in social media data. This may help public health programming to prevent suicide and computational social science research and investigations that rely on the quality of labels for downstream machine learning tasks.
Social Media Sharing of Articles About Measles in a European Context: Text Analysis Study (Preprint)
Authors: Wawrzuta Dominik , Jaworski Mariusz , Gotlib Joanna , Panczyk Mariusz
Published: November 2021

BACKGROUND

Despite the existence of an effective vaccine, measles still threatens the health and lives of many Europeans. Notably, during the COVID-19 pandemic, measles vaccine uptake declined; as a result, after the pandemic, European countries will have to increase vaccination rates to restore the extent of vaccination coverage among the population. Because information obtained from social media are one of the main causes of vaccine hesitancy, knowledge of the nature of information pertaining to measles that is shared on social media may help create educational campaigns.

OBJECTIVE

In this study, we aim to define the characteristics of European news about measles shared on social media platforms (ie, Facebook, Twitter, and Pinterest) from 2017 to 2019.

METHODS

We downloaded and translated (into English) 10,305 articles on measles published in European Union countries. Using latent Dirichlet allocation, we identified main topics and estimated the sentiments expressed in these articles. Furthermore, we used linear regression to determine factors related to the number of times a given article was shared on social media.

RESULTS

We found that, in most European social media posts, measles is only discussed in the context of local European events. Articles containing educational information and describing world outbreaks appeared less frequently. The most common emotions identified from the study’s news data set were fear and trust. Yet, it was found that readers were more likely to share information on educational topics and the situation in Germany, Ukraine, Italy, and Samoa. A high amount of anger, joy, and sadness expressed within the text was also associated with a higher number of shares.

CONCLUSIONS

We identified which features of news articles were related to increased social media shares. We found that social media users prefer sharing educational news to sharing informational news. Appropriate emotional content can also increase the willingness of social media users to share an article. Effective media content that promotes measles vaccinations should contain educational or scientific information, as well as specific emotions (such as anger, joy, or sadness). Articles with this type of content may offer the best chance of disseminating vital messages to a broad social media audience.
A Mobile App for Advance Care Planning and Advance Directives (Accordons-nous): Development and Usability Study (Preprint)
Authors: Schöpfer Céline , Ehrler Frederic , Berger Antoine , Bollondi Pauly Catherine , Buytaert Laurence , De La Serna Camille , Hartheiser Florence , Fassier Thomas , Clavien Christine
Published: November 2021

BACKGROUND

Advance care planning, including advance directives, is an important tool that allows patients to express their preferences for care if they are no longer able to express themselves. We developed Accordons-nous, a smartphone app that informs patients about advance care planning and advance directives, facilitates communication on these sensitive topics, and helps patients express their values and preferences for care.

OBJECTIVE

The first objective of this study is to conduct a usability test of this app. The second objective is to collect users’ critical opinions on the usability and relevance of the tool.

METHODS

We conducted a usability test by means of a think-aloud method, asking 10 representative patients to complete 7 browsing tasks. We double coded the filmed sessions to obtain descriptive data on task completion (with or without help), time spent, number of clicks, and the types of problems encountered. We assessed the severity of the problems encountered and identified the modifications needed to address these problems. We evaluated the readability of the app using Scolarius, a French equivalent of the Flesch Reading Ease test. By means of a posttest questionnaire, we asked participants to assess the app’s usability (System Usability Scale), relevance (Mobile App Rating Scale, section F), and whether they would recommend the app to the target groups: patients, health professionals, and patients’ caring relatives.

RESULTS

Participants completed the 7 think-aloud tasks in 80% (56/70) of the cases without any help from the experimenter, in 16% (11/70) of the cases with some help, and failed in 4% (3/70) of the cases. The analysis of failures and difficulties encountered revealed a series of major usability problems that could be addressed with minor modifications to the app. Accordons-nous obtained high scores on readability (overall score of 87.4 on Scolarius test, corresponding to elementary school level), usability (85.3/100 on System Usability Scale test), relevance (4.3/5 on the Mobile App Rating Scale, section F), and overall subjective endorsement on 3 I would recommend questions (4.7/5).

CONCLUSIONS

This usability test helped us make the final changes to our app before its official launch.
Peer Mentoring Program for Informal Caregivers of Homebound Individuals With Advanced Parkinson Disease (Share the Care): Protocol for a Single-Center, Crossover Pilot Study (Preprint)
Authors: Fleisher Jori E , Akram Faizan , Lee Jeanette , Klostermann Ellen C , Hess Serena P , Myrick Erica , Levin Melissa , Ouyang Bichun , Wilkinson Jayne , Hall Deborah A , Chodosh Joshua
Published: November 2021

BACKGROUND

Homebound individuals with advanced Parkinson disease (PD) require intensive caregiving, the majority of which is provided by informal, family caregivers. PD caregiver strain is an independent risk factor for institutionalization. There are currently no effective interventions to support advanced PD caregivers. Studies in other neurologic disorders, however, have demonstrated the potential for peer mentoring interventions to improve caregiver outcomes. In the context of an ongoing trial of interdisciplinary home visits, we designed and piloted a nested trial of caregiver peer mentoring for informal caregivers of individuals with advanced PD.

OBJECTIVE

The aim of this study was to test the feasibility of peer mentoring for caregivers of homebound individuals with advanced PD and to evaluate its effects on anxiety, depression, and caregiver strain.

METHODS

This was a single-center, 16-week pilot study of caregiver peer mentoring nested within a year-long controlled trial of interdisciplinary home visits. We recruited 34 experienced former or current family caregivers who completed structured mentor training. Caregivers enrolled in the larger interdisciplinary home visit trial consented to receive 16 weeks of weekly, one-to-one peer mentoring calls with a trained peer mentor. Weekly calls were guided by a curriculum on advanced PD management and caregiver support. Fidelity to and satisfaction with the intervention were gathered via biweekly study diaries. Anxiety, depression, and caregiver strain were measured pre- and postmentoring intervention at home visits 2 and 3.

RESULTS

Enrollment and peer-mentor training began in 2018, and 65 caregivers enrolled in the overarching trial. The majority of mentors and mentees were White, female spouses or partners of individuals with PD; mentors had a mean of 8.7 (SD 6.4) years of caregiving experience, and 33 mentors were matched with at least 1 mentee.

CONCLUSIONS

This is the first study of caregiver peer mentoring in PD and may establish an adaptable and sustainable model for disease-specific caregiver interventions in PD and other neurodegenerative diseases.

CLINICALTRIAL

ClinicalTrials.gov NCT03189459; http://clinicaltrials.gov/ct2/show/NCT03189459

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/34750
Disease Activity and Adverse Events in Patients with ANCA-Associated Vasculitides Undergoing Long-Term Dialysis
Authors: Kauffmann Maëlis , Bobot Mickaël , Robert Thomas , Burtey Stéphane , Couvrat-Desvergnes Grégoire , Lavainne Frédéric , Puéchal Xavier , Terrier Benjamin , Quéméneur Thomas , Faguer Stanislas , Karras Alexandre , Brunet Philippe , Couchoud Cécile , Jourde-Chiche Noémie
Published: November 2021

Background and objectives

Kidney impairment of ANCA-associated vasculitides can lead to kidney failure. Patients with kidney failure may suffer from vasculitis relapses but are also at high risk of infections and cardiovascular events, which questions the maintenance of immunosuppressive therapy.

Design, setting, participants, & measurements

Patients with ANCA-associated vasculitides initiating long-term dialysis between 2008 and 2012 in France registered in the national Renal Epidemiology and Information Network registry and paired with the National Health System database were included. We analyzed the proportion of patients in remission off immunosuppression over time and overall and event-free survival on dialysis (considering transplantation as a competing risk). We compared the incidence of vasculitis relapses, serious infections, cardiovascular events, and cancers before and after dialysis initiation.

Results

In total, 229 patients were included: 142 with granulomatous polyangiitis and 87 with microscopic polyangiitis. Mean follow-up after dialysis initiation was 4.6±2.7 years; 82 patients received a kidney transplant. The proportion of patients in remission off immunosuppression increased from 23% at dialysis initiation to 62% after 5 years. Overall survival rates on dialysis were 86%, 69%, and 62% at 1, 3, and 5 years, respectively. Main causes of death were infections (35%) and cardiovascular events (26%) but not vasculitis flares (6%). The incidence of vasculitis relapses decreased from 57 to seven episodes per 100 person-years before and after dialysis initiation (P=0.05). Overall, during follow-up, 45% of patients experienced a serious infection and 45% had a cardiovascular event, whereas 13% experienced a vasculitis relapse.

Conclusions

The proportion of patients with ANCA-associated vasculitis in remission off immunosuppression increases with time spent on dialysis. In this cohort, patients were far less likely to relapse from their vasculitis than to display serious infectious or cardiovascular events.

Podcast

This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2021_11_08_CJN03190321.mp3
Research on the Strategy of Improving College Students’ Career Adaptability in Application-oriented Colleges and Universities
Authors: Ping-qian Guo
Published: November 2021

Application-oriented colleges and universities have become the main force in the popularization of higher education in China, and their school running orientation is to cultivate application-oriented talents to adapt to social development. Career adaptability is a hot topic in the field of career psychology abroad. Therefore, it is of great significance to carry out the education of improving college students’ career adaptability in Application-oriented Colleges and universities, summarize college students’ career adaptability, analyze the necessity of improving college students’ career adaptability at this stage, and put forward the strategies of improving college students’ career adaptability in Application-oriented Colleges and universities, so as to enable students to achieve real job matching in the process of employment.
On solving classes of positive-definite quantum linear systems with quadratically improved runtime in the condition number
Authors: Orsucci Davide , Dunjko Vedran
Published: November 2021

Quantum algorithms for solving the Quantum Linear System (QLS) problem are among the most investigated quantum algorithms of recent times, with potential applications including the solution of computationally intractable differential equations and speed-ups in machine learning. A fundamental parameter governing the efficiency of QLS solvers is κ, the condition number of the coefficient matrix A, as it has been known since the inception of the QLS problem that for worst-case instances the runtime scales at least linearly in κ [Harrow, Hassidim and Lloyd, PRL 103, 150502 (2009)]. However, for the case of positive-definite matrices classical algorithms can solve linear systems with a runtime scaling as κ, a quadratic improvement compared to the the indefinite case. It is then natural to ask whether QLS solvers may hold an analogous improvement. In this work we answer the question in the negative, showing that solving a QLS entails a runtime linear in κ also when A is positive definite. We then identify broad classes of positive-definite QLS where this lower bound can be circumvented and present two new quantum algorithms featuring a quadratic speed-up in κ: the first is based on efficiently implementing a matrix-block-encoding of A−1, the second constructs a decomposition of the form A=LL† to precondition the system. These methods are widely applicable and both allow to efficiently solve BQP-complete problems.
A Comprehensive System for Identifying Patients With Type 1 Diabetes at Increased Risk for Diabetic Ketoacidosis at Texas Children’s Hospital
Authors: Schwartz David D. , Vakharia Mili , Uysal Serife , Hendrix Kristen R. , Fegan-Bohm Kelly , Lyons Sarah K. , Sonabend Rona , Gunn Sheila K. , Banuelos Rosa , Dei-Tutu Selorm
Published: November 2021

Quality Improvement Success Stories are published by the American Diabetes Association in collaboration with the American College of Physicians and the National Diabetes Education Program. This series is intended to highlight best practices and strategies from programs and clinics that have successfully improved the quality of care for people with diabetes or related conditions. Each article in the series is reviewed and follows a standard format developed by the editors of Clinical Diabetes. The following article describes a project at Texas Children’s Hospital aimed at improving identification of patients with type 1 diabetes at high risk for diabetic ketoacidosis.
INFLASI DARI SUDUT PANDANG MONETER DAN FISKAL (STUDI KASUS SUMATERA BARAT)
Authors: Azhar Zul , Satrianto Alpon , Nofitasari Nofitasari
Published: November 2021

This study aims to analyze the effect of money supply M2, interest rate, government spending and local tax on the inflation in West Sumatera. This type of research is descriptive research and secondary datain the form of time-series from quartely 1 2007 to 2017 quartely 4 using the method of Autoregresive Distributed Lag analysis. The results of this study indicate that money supply in the long run have a significant and positive effect on inflation West Sumatera. In the short run  and long run the interest rate has a significant and positive effect on inflation in West Sumatera. Government spending in the Long run has a significant and negative effect on inflation in West Sumatera. Based on the result of this study can be concluded that there is inflation in West Sumatera is monetery of phenomenon in the long run.
ANALISIS KAUSALITAS SHOCK HARGA MINYAK DUNIA, PENGELUARAN DAN PENERIMAAN PEMERINTAH DI INDONESIA
Authors: Mailida Yulfia , Azhar Zul , Adry Melti Roza
Published: November 2021

This study aims to know and analyze the causality between oil world price, government expenditure and government revenue in Indonesia, which is analyzed using Vector Error Correction Model (VECM) method. The result of this study indicate oil world price and government expenditure have a causality in Indonesia, oil world price do not have a causality government revenue in Indonesia and government expenditurein Indonesia do not have causality  government expenditure in Indonesia. Based oo the result of this study it can be conclued that there have two variabel a causality.
PENGARUH PENANAMAN MODAL ASING (PMA), PENANAMAN MODAL DALAM NEGERI (PMDN), KUALITAS SUMBERDAYA MANUSIA (SDM), DAN TINGKAT PARTISIPASI ANGKATAN KERJA (TPAK) TERHADAP PEREKONOMIAN DI INDONESIA
Authors: Dely Nilma , Amar Syamsul , Satrianto Alpon
Published: November 2021

This study aims to determine and analyze the effect of Foreign Investment (PMA), Domestic Investment (PMDN) on Human Resource Quality (HR) and Labor Force Participation Rate (TPAK) on the Economy in Indonesia, where the quality of human resources is measured using the average length school residents aged 15 years and over. This type of research is descriptive and associative research, namely research that describes the research variable and finds the presence or absence of influence between independent variables and dependent variables. The types of data in this study are secondary data and panel data from 2012-2016 per Province in Indonesia. Data analysis used is descriptive analysis and inductive analysis. In inductive analysis there are several tests, namely: Panel Regression Model, Classical Assumption Test, t Test. The results of this study indicate that (1) Foreign investment (PMA) has a positive and significant effect on the economy in Indonesia, (2) domestic investment (PMDN) has a negative and not significant effect on the economy in Indonesia, (3) the quality of human resources has a positive effect and significant to the economy in Indonesia, (4) the level of labor force participation (TPAK) has a positive and significant effect on the economy in Indonesia. By using α = 5%.
ANALISIS VARIABEL MONETER AMERIKA SERIKAT TERHADAP PERTUMBUHAN EKONOMI NEGARA EMERGING MARKET
Authors: Oktaviani Sindi , Aimon Hasdi , Putri Dewi Zaini
Published: November 2021

This study aims to find effect of monetary variable of US on economic growth in emerging market countries, such as Indonesian, Malaysian, Thailand and Philipines. These four countries are commonly called tiger cub countries that have the potential to become developed countriesin the future. The data used are secondary data in the form of time series from 2010:Q1 until 2018:Q4. The variables used are gap of The Fed Funds rate and gap of Inflation of US as exogen variable. Then, exchange rate and economic growth as endogen variable. The research methods used are simultaneous equation regression model with indirect least square methode. The results of the study show that (1)Gap of The Fed Interest Rate has a significant effect on the exchange rate in all sample of Emerging Market Countries while US inflation only has a significant effect on the exchange rate in Indonesia.(2) in simultaneously gap of The Fed Interest rate, gap of US inflation and the exchange rate which contaminated by changes in the US monetary variable have a significant influence on economic growth in Emerging Market Countries, except in Malaysian.(3) In partially, gap of The Fed Interest rate and the exchange rate have a significant influence on economic growth in Indonesian, Thailand and Philipines.While gap of US inflation has a significant influence on economic growth only in Indonesian and Philipines.
ANALISIS PERAN GANDA WANITA TERHADAP KESEJAHTERAAN DI SUMATERA BARAT
Authors: Agustin Tria , Triani Mike
Published: November 2021

This study aims to analyze the influence of factors (X1) Wife's working hours on welfare, (X2) Wife's last education on welfare, (X3) Husband's last education on welfare in West Sumatra. This study uses the logistic regression method. The sample used was taken from prosperous households based on per capita expenditure in West Sumatra. This study uses Susenas West Sumatra Province data in 2015. The results of the study show that (1) wife's working hours have a significant effect on welfare. (2) Last wife education has a significant effect on welfare. (3) Husband's last education has a significant effect on welfare. (4) Taken together there are significant effects between wife's working hours, wife's last education, and husband's last education on welfare in West Sumatra. From the results of research, Welfare and the dual role of women generally have a positive relationship or relationship. Especially for prosperous households. Households whose wives are involved in earning a living will tend to be more prosperous than households whose wives do not play a role in earning a living, so special attention from the government is needed to provide job training for wives to have skills so that they can play an active role in economy and impact on households that tend to be more prosperous.