bluuebunny/crossref_metadata_2025 huggingface dataset:
Chemical Composition of the Essential oil of The Leaves of Pimenta diocia (L.) Merr. & Pimenta racemosa (Mill.) cultivated in Egypt and Evaluation of Their in-vitro Antioxidant and Antidiabetic Activities
Authors: El-gizawy Heba Abd-Elhady , Mosaad Yasser Omar , Gobba Naglaa Abd El Khalik , Hussein Mohammed Abdalla
Published: July 2020

The aim of the study is to identify and characterize the chemical composition of the essential oil of both leaves of Pimenta diocia (L.) Merr. and Pimenta racemosa (Mill.)  as well as to evaluate their in-vitro antioxidant and anti-diabetic potency. Both leaves essential oil was analyzed by GC-MS analysis. Different in-vitro antioxidant tests were employed, namely, 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric thiocyanate (FTC), ferric reducing antioxidant power, thiobarbituric acid (TBA) and β-carotene-linoleate bleaching assay. Also, the present work aims to evaluate the α-amylase and α-glucosidase inhibition as well as glucose uptake by yeast cells of essential oils. Essential oil analysis of the leaves of Pimenta racemosa (Mill.) showed high amounts of eugenol (37.95%), β-Myrecene (21.01%), α-Pinene (17.82%), linalool (6.15%) and limonene (5.93%).  GC-MS data of leaves essential oil revealed the presence of  eugenol (30.17%), limonene (17.24),  α-Pinene (16.78%), linalool (9.71), 1,8 cineole (8.31%) and β-myrecene (5.21%) . Pimenta diocia (L.) Merr. and Pimenta racemosa (Mill.) leaves essential oil having antioxidant effect using various methods. In most of the oil samples and assays the antioxidant activity was higher than the one revealed by the positive control BHT. Both plants essential oil showed potent inhibition of α-Amylase at concentration 2.00 mg as it was inhibited by (75 and 63 %); with IC50 (0.95 and 1.13); respectively as well as inhibition of α-glucosidase enzyme by (61.42 and 53.00%) with IC50 (3.17 and 4.25); respectively. Also the percentage of glucose uptake by Pimenta diocia (L.) Merr. and Pimenta racemosa (Mill.) leaves essential oil at 2.00 mg/ml in the presence of 25 mM glucose is (63.49% and 49.61%); respectively. Conclusion: the present study clearly identified the Egyptian chemotype of Pimenta diocia (L.) Merr. and Pimenta racemosa (Mill.) leaves essential oil, it also displayed safe and promising antidiabetic and antioxidant properties. Therefore the essential oil of both species can be utilized as a natural antioxidant and antidiabetic as well as health benefits.
SAR image observations of the A-68 iceberg drift
Authors: Lopez-Lopez Ludwin , Parmiggiani Flavio , Moctezuma-Flores Miguel , Guerrieri Lorenzo
Published: July 2020

Abstract. A methodology for examining a temporal sequence of Synthetic Aperture Radar (SAR) images as applied to the detection of the A-68 iceberg and its drifting trajectory, is presented. Using an improved image processing scheme, the analysis covers a period of eighteen months and makes use of a set of Sentinel-1 images. A-68 iceberg calved from the Larsen C ice shelf in July 2017 and is one of the largest icebergs observed by remote sensing on record. After the calving, there was only a modest decrease in the area (about 1 %) in the first six months. It has been drifting along the east coast of the Antarctic Peninsula and it is expected to continue its path for more than a decade. It is important to track the huge A-68 iceberg to retrieve information on the physics of iceberg dynamics and for maritime security reasons. Two relevant problems are addressed by the image processing scheme presented here: (a) How to achieve quasi-automatic analysis using a fuzzy logic approach to image contrast enhancement, and (b) Adoption of ferromagnetic concepts to define a stochastic segmentation. The Ising equation is used to model the energy function of the process, and the segmentation is the result of a stochastic minimization.
Anamnesis del mundo clásico en la configuración política de los Estados Unidos de América
Authors: Sánchez Andrada Francisco de Sales
Published: July 2020

Tomando como objetivo analizar la configuración constitucional de los Estados Unidos, se aborda la influencia que tuvo, en los padres fundadores, la teoría cultural y política heredada del mundo clásico. En este sentido, recorreremos las referencias al mundo clásico de los ideólogos de la Constitución de 1787 en relación con los aspectos simbólicos y culturales que influyeron en la conformación de la nación norteamericana a fin de aterrizar en nuestra tesis; a saber, que en la construcción de un edificio constitucional esencial en tanto paradigma de la democracia representativa y donde Montesquieu es considerado el oráculo, encontramos en los cimientos el legado de una teoría política clásica que, naciendo en Platón y Aristóteles, desemboca en Polibio.
Corporate Social Responsibility Disclosure and Financial Performance of Firms in Kenya: A Stakeholder Approach
Authors: King’wara Robert A.
Published: July 2020

Using panel data set from companies listed on the Nairobi Securities Exchange in Kenya, a developing country, this paper examines the potential influence of corporate social responsibility disclosure (CSRD) on corporate financial performance. Using data from annual reports, CSRD information was collected for the period 2007-2015 using quantitative content analysis while financial performance data was collected for the period 2008-2016, a one-year lag behind CSRD data. Control variables were firm size, industry type and leverage. There was found to be no statistically significant impact of CSRD on financial performance. Since neutrality of the relationship is empirically proven, the conclusion is that CSRD has little or no contribution to financial performance and the implication is that effective financial reporting for companies listed on the NSE does not include reporting on CSR activities. Theoretically the study proposes that unequal controlling strengths of different stakeholders be assumed under the stakeholder theory for application within different national contexts in order for managers to be able to make the necessary tradeoffs among competing stakeholders.
The Effect of Ensiling Sugar Beets on Preservation Characteristics, Nutrient Profile, and in Situ Disappearance
Authors: Van Emon Megan
Published: July 2020

The objective of this project was to determine if sugar beets could be ensiled with hay or soybean meal with or without a liquid mold inhibitor and the impact on nutrient composition, pH, and aerobic stability. A 3 x 2 factorial experiment where hay (control; H) or sugar beets mixed with either hay (SBH) or soybean meal (SB) were ensiled at a rate of 50:50 (as fed) without the mold inhibitor. The mold inhibitor (T) was included to create three additional treatments: HT, SBT, and SBHT. All treatments decreased in pH over time (P < 0.01), with the lowest pH value being generated by the SB treatment. Concentrations of NDF increased between d 0 and d 90 for treatments SB and SBT (P ≤ 0.01) and increased between d 90 and d 180 for treatments H, HT, SBH, and SBHT (P ≤ 0.01). Concentrations of ADF also increased among all treatments (P ≤ 0.05). Concentrations of CP increased from d 0 to d 90 for HT and SB treatments (P ≤ 0.01), increased from d 90 to d 180 for the SBT treatment (P ≤ 0.02), increased from d 0 to d 180 for the SBH treatment (P ≤ 0.03), and decreased from d 90 to d 180 for the SB treatment (P ≤ 0.01). The data suggests that sugar beets may be ensiled with hay or soybean meal, with or without a liquid mold inhibitor, without negatively impacting nutrient quality or preservation characteristics of the ensiled mixture.
Evaluación de un intercambiador de calor de placas para el enfriamiento de ácido acético
Authors: Pérez Sánchez A. , Pérez Sánchez E.J. , Ranero Gonzalez E.
Published: July 2020

En las aplicaciones de intercambio de calor actuales, el intercambiador de calor de placas (ICP) es muy empleado en las industrias químicas y la alimenticia. En el presente trabajo se efectuó la evaluación de un ICP para llevar a cabo el enfriamiento de una corriente de ácido acético, utilizando etilenglicol como agente refrigerante. Se obtuvo un valor del porcentaje de sobrediseño de superficie (PSS) de 29,34 %, una efectividad de transferencia de calor (ε) de 0,667, un número de unidades de transferencia (NUT) de 1,316, mientras que las caídas de presión de tanto el ácido acético (6,70 kPa) como el etilenglicol (82,06 kPa) se encontraron por debajo del límite máximo permisible por el proceso (100 kPa). El incremento del caudal de alimentación del ácido acético aumentó los valores de los tres parámetros considerados, mientras que el incremento de la temperatura de entrada del ácido acético aumentó tres de las variables tomadas en cuenta, con excepción de la caída de presión del ácido acético, que se redujo. El ICP propuesto puede ser empleado satisfactoriamente para el proceso de transferencia de calor evaluado.
Study of dynamic reaction of tubulins in microtubules. A qm/mm simulation
Authors: Naghsh Farnoush , Monajjemi Majid , Zare Karim
Published: July 2020

In this model one-dimensional microtubule is fixed at one of the two and simulated while the opposite end is allowed for growing in random situation. By this study at each step one tubulin has been added to the length for growing microtubule length. Computationally this can be done through generating a uniform random number between (0, 1). Microtubules are demonstrated as straight macromolecules consist of the linear chains of tubulin subunits in the length. QM/MM simulation has been applied to study dynamic instability of the microtubule length. It has been calculated a correct dimension around 10-6 meter of microtubules length consist of around 1650 tubulin dimers.  Microtubule growth rate is related to the soluble tubulin dimer concentration and for all results shown here, simulation of any single condition was run 5–10 times.
Composition and age of monacite fragments from superior jurassic terrigenous sediments of bazhenov formation foundation (multan area in west siberia)
Authors: Erokhin Yuriy V. , Ivanov Kirill S. , Khiller Vera V.
Published: July 2020

Bazhenov Formation is regarded as the main oil-bearing stratum mothering nearly all the fields of the Western Siberia Oil-Gas-bearing Megabasin. Presently, it is one of the most studied formations of Siberia and, probably, Eurasia as a whole. While there is an enormous amount of studies devoted to the Bazhenov Formation, there are no detailed mineralogical studies at the modern hardware level. The age and sources of the terrigenous materials of the formation have not been studied as well. We have explored the detrital monazite from the upper-Jurassic terrigenous sediments of the Multan Area at the foundation of the Bazhenov Formation in the central part of Western Siberia, Surgut District. All the detrital rare earth phosphate is of the cerium kind being a monazite-(Се). The mineral is rather dissimilar in respect of its chemical properties, especially, the content of thorium. Some fragments have been subjected to superposed secondary changes. The detrital monazite is rounded to various degrees which is indicative of the various distances from the rare earth phosphate orebody washout. As per the chemical data, most of the monazite has been washed out from the medium and basic rocks (probably subalkaline or alkaline) as well as the sialic rocks (granitoids and associated veins). According to the chemical dating, most of the monazite fragments have been washed out of the very ancient Proterozoic formations and lower-Proterozoic rocks. Terrigenous materials derives probably from the rock assemblages of the eastern and south-eastern fringes of the Western Siberian megabasin such as the Proterozoic Yenisei Ridge or Lower-Proterozoic blocks of the Altay and Sayan Faulting.
Aromaticity study of heterocyclic anticancer compounds through computational s-nics method
Authors: Shekarkhand Marzieh , Zare Karim , Monajjemi Majid , Tazikeh-Lemeski Elham , Sayadian Masoumeh
Published: July 2020

In this study, we have sujessted a theoritical aproach via computing of nucleus-independent chemical shifts (S-NICS) in view point of probes motions in a sphere of de-shielding and shielding spaces of rings of anticancer contain heterocyclic rings. Few research in theoretical of a statistical approach in NMR shielding and nucleus independent chemical shifts for study of anticancer drugs. S-NICS method is an accurate method for estimation the amount of aromaticity in the non-benzene rings such as heterocyclic rings which is a famous for organic chemical compounds as anti-cancer disease. Theoretical of a statistical method of NICS-nucleus independent chemical shift in small distance and are alternate in large distance in the center of heterocyclic rings. In this research, we have explored the statistical approaches through nucleus-independent chemical shifts-SNICS calculations in view point of Bq motions in the center of sphere spaces of heterocyclic rings of some anticancer drugs. The S-NICS method is an accurate computing method for estimation the aromaticity in the non-benzene rings such as heterocyclic rings which are standard molecules in organic anti-cancer compounds. Although NICS values for benzene and naphthalene and so on can be indicated as aromaticity criterion, for other molecules such as heterocyclic rings and their derivatives, S-NICS values are much more accurate compare to NICS index. Hetrocyclic compound with good π stacks are good cacdidate for anticancer medicines.  Precence of Nitrogen, oxygen and sulfur in these compounds make them similar biochemical parts such as nuclice acids and. Aromaticity of heterocyclic ring.   This similarity especially them π stacks give the the ability of interaction with DNAs and RNAs and the heterocyclic compounds.
Promoting Students’ Autonomy through Online Learning Media in EFL Class
Authors: Muhammad Muhammad
Published: July 2020

The trend of teaching English as foreign language in 21st century has changed from teacher centered to students centered paradigm which results the need of students’ autonomy in learning process. Then, this research was aimed to depict how the schoology as e-media to promote 25 VII A class students’ autonomy in learning English as foreign language (EFL) in discourse analysis course. This was a case study qualitative research by applying triangulation of the data. The results of this research mentioned that schoology successfully promoted students’ autonomy by considering some facts such as students active participations through logging in and commenting others’ idea; students’ control on deciding learning modes, setting, and materials; and students’ enthusiasm to finish the lecturer’s challenges. One unique thing was that shy students were more active in Schoology. Finally, this research suggests to present schoology in teaching content course.
Schools Teachers' Experiences of Social Network Sites in Relation to Improving the Skills of Arabic Language Acquisition: Impact, Strengths, and Weaknesses
Authors: Jwaifell Mustafa , Abu-Omar Reema , BaniAbdel-Rahman Mahmoud
Published: July 2020

This paper investigates elementary and secondary teachers' experiences of the impact, strength, and weaknesses of Social Network Sites (SNS) with regard to improving students' acquisition of Arabic Language. The study sample consisted of (85) Arabic language teachers; (77) of them responded to a questionnaire that measured their experiences of SNS's impact, strengths, and weaknesses. The researchers used descriptive statistics, ANOVA and T-test. The data analyses revealed an existent of impact, strengths, and weaknesses of SNS on elementary and secondary students’ acquisition of Arabic Language. The study recommended the focus on overcoming weaknesses and taking advantage of using SNS in learning environments.
Analytical Assessment of the Common Writing Errors among Saudi Foundation Year Students: A Comparative Study
Authors: Shousha Amal Ibrahim , Farrag Nahed Moussa , Althaqafi Abeer Sultan
Published: July 2020

This research explored the most common writing errors of Science and Arts students of the Foundation year program at a Saudi University that hinder them from achieving their course goals, learning outcomes and becoming efficient writers. The importance of this research stems from the fact that, it is a comparative study that shows the differences in writing errors between Science and Arts students and relates writing difficulties to students’ background education, family support, level of the language and teacher’s feedback techniques. It unveils the causes of writing errors and suggests suitable remedies from teacher’s perspectives. The findings can be useful for teachers, students and course designers.
Adaptive Filter as Efficient Tool for Data Assimilation under Uncertainties
Authors: Son Hoang Hong , Baraille Remy
Published: July 2020

In this contribution, the problem of data assimilation as state estimation for dynamical systems under uncertainties is addressed. This emphasize is put on high-dimensional systems context. Major difficulties in the design of data assimilation algorithms is a concern for computational resources (computational power and memory) and uncertainties (system parameters, statistics of model, and observational errors). The idea of the adaptive filter will be given in detail to see how it is possible to overcome uncertainties as well as to explain the main principle and tools for implementation of the adaptive filter for complex dynamical systems. Simple numerical examples are given to illustrate the principal differences of the AF with the Kalman filter and other methods. The simulation results are presented to compare the performance of the adaptive filter with the Kalman filter.
Phage Display as a Strategy to Obtain Anti-flavivirus Monoclonal Antibodies
Authors: Beatriz Borges Silva Isaura , Kaylan Alves de Oliveira França Renato , Medeiros Silva Jacyelly , Queiroz Maranhão Andrea , Roberto Prudencio Carlos
Published: July 2020

Arbovirus of the Flaviviridae family represents an issue worldwide, particularly because it can lead to serious illness and death in some countries. There is still a great complexity in obtaining effective therapies and specific and sensitive diagnostic tests, due to the high antigenic similarity between them. This similarity may account for antibodies cross reactivity which has positive and negative consequences for the course of infectious diseases. Among dengue virus (DENV) serotype infections, the cross-reactivity can increase virus replication and the risk of a severe disease by a mechanism known as an antibody-dependent enhancement (ADE). The search for serological biomarkers through monoclonal antibodies (MAbs) that identify unique viral regions can assist in the differential detection, whereas the development of recombinant antibodies with a neutralizing potential can lead to the establishment of efficacious treatments. The Phage Display methodology emerged as one of the main alternatives for the selection of human MAbs with high affinity for a specific target. Therefore, this technology can be a faster alternative for the development of specific diagnostic platforms and efficient and safe treatments for flavivirus infections. In this context, we propose for this chapter a discussion about Phage Display as a strategy to obtain MAbs for DENV and other flaviviruses.
Methods of Nonequilibrium Statistical Mechanics in Models for Mixing Bulk Components
Authors: Kapranova Anna , Bahaeva Daria , Stenko Dmitry , Verloka Ivan , Lebedev Anton , Tarshis Mikhail
Published: July 2020

When describing the mechanics of the behavior of bulk materials during their mixing, a theoretical basis for the design of the specified equipment is formed. In recent years, the most well-known methods of modeling this process include the stochastic approach, in the framework of which models of the following types are actively developing: cell, managerial, with time series, energy, etc. Moreover, as a rule, predicting the quality of the finished mixture according to the selected criterion is achieved by using numerical calculation methods based on the generated cyber system. Of particular interest is the use of the energy method from the statistical mechanics of nonequilibrium processes due to the possibility of obtaining analytical simulation results. The paper describes the motion models of bulk components in rarefied flows, which are built on the basis of the energy method and take into account the main characteristics of the studied mixing process.
Kinematics of Serial Manipulators
Authors: Virgala Ivan , Kelemen Michal , Prada Erik
Published: July 2020

This book chapter deals with kinematic modeling of serial robot manipulators (open-chain multibody systems) with focus on forward as well as inverse kinematic model. At first, the chapter describes basic important definitions in the area of manipulators kinematics. Subsequently, the rigid body motion is presented and basic mathematical apparatus is introduced. Based on rigid body conventions, the forward kinematic model is established including one of the most used approaches in robot kinematics, namely the Denavit-Hartenberg convention. The last section of the chapter analyzes inverse kinematic modeling including analytical, geometrical, and numerical solutions. The chapter offers several examples of serial manipulators with its mathematical solution.
How Could We Rescue the World Today?
Authors: Irigaray Luce ,   International Association for Environmental Philosophy
Published: July 2020

The distress of our world, and the danger in which we are today, force us to think about the way according to which life can still be saved, beginning with our human life. The undertaking of thinking must take root again in what is most essential for life itself, and for its cultivation. This requires us to question about the manner in which our tradition has assembled beings into a whole, but also the manner in which we can collect and gather ourselves together—each one and between us. Obviously, money cannot achieve such undertaking. Sexuate difference could if we become able to perceive and acknowledge its importance for human life, for its development, and for its sharing.
Ansiedade, depressão e estresse em cuidadores de sobreviventes de acidente vascular encefálico
Authors: Costa Tatiana Ferreira da , Ferreira Gerlania Rodrigues Salviano , Pimenta Cláudia Jeane Lopes , Silva Cleane Rosa Ribeiro da , Leal Natália Pessoa da Rocha , Bezerra Thaíse Alves , Costa Kátia Neyla de Freitas Macedo
Published: July 2020

Objetivo: associar a ansiedade, a depressão e o estresse às características sociodemográficas, hábitos de vida, situação de saúde e dados da prestação do cuidado em cuidadores de sobreviventes de acidente vascular encefálico. Método: estudo transversal realizado com 151 cuidadores informais primários em João Pessoa, Paraíba, Brasil. Foram utilizados um instrumento semiestruturado e a Escala de Ansiedade, Depressão e Estresse-21, sendo os dados analisados por estatística descritiva e inferencial. Resultados: os cuidadores com mais anos de estudo tiveram maior média de estresse. Os que se sentiam sempre cansados apresentaram maiores médias para ansiedade, depressão e estresse, bem como aqueles que mencionaram seu estado de saúde como ruim e os que dedicavam mais de 10 horas por semana ao cuidado. Os participantes que não praticavam atividade de lazer obtiveram maiores médias de depressão e estresse, os que auxiliavam na medicação foram relacionados a maior média de ansiedade e os que ajudavam na locomoção relataram maiores médias de depressão e estresse. Conclusões: foi observado que os níveis de ansiedade, depressão e estresse sofreram influência de algumas características pessoais, hábitos de vida, situação de saúde e características do cuidado prestado ao familiar vítima de acidente vascular encefálico.
Los derechos fundamentales y la acción de los poderes públicos
Authors: Fernández Tomás Ramón
Published: July 2020

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Las diputaciones permanentes y el control sobre el decreto-ley
Authors: Jiménez Campo Javier
Published: July 2020

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La televisión privada y la Constitución
Authors: Quadra-Salcedo Tomás de la
Published: July 2020

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Regulación de la actividad internacional del Estado en la Constitución
Authors: Rodríguez Carrión Alejandro J
Published: July 2020

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Los partidos políticos y su lugar en el sistema político español (I)
Authors: Águila Tejerina Rafael del
Published: July 2020

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Jurisprudencia constitucional
Authors: Departamento de Derecho Administrativo de la UNED -
Published: July 2020

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Controles preventivos y reparadores de la constitucionalidad intrínseca de los tratados internacionales
Authors: Remiro Brotons Antonio
Published: July 2020

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Observaciones sobre el papel del Tribunal Constitucional en la delimitación de competencias entre Estado y Comunidades Autónomas.
Authors: Elizande José
Published: July 2020

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La defensa de la Constitución
Authors: Tomás y Valiente Francisco
Published: July 2020

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Elecciones legislativas en Holanda
Authors: Mellado Prado Pilar
Published: July 2020

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El retorno de la izquierda en Suecia
Authors: Ollero Butler Fernando
Published: July 2020

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Crónica parlamentaria sobre el Tribunal Constitucional
Authors: Gonzalo Manuel
Published: July 2020

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Rasgos definidores de la iniciativa legislativa prevista en el artículo 87 de la Constitución (I)
Authors: Merino Merchán José Fernando
Published: July 2020

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Congreso Extraordinario de Unión de Centro Democrático (UCD)
Authors: Gómez Sánchez Yolanda
Published: July 2020

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Elecciones en Hamburgo
Authors: Beneyto José María
Published: July 2020

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Crónica parlamentaria
Authors: Gonzalo Manuel
Published: July 2020

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Pragmatismo jurídico y concertación política : dos ideas-clave en la obra de los constituyentes de 1837
Authors: Fernández Segado Francisco
Published: July 2020

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La práctica electoral bajo la Constitución de 1837
Authors: Cases Méndez José Ignacio
Published: July 2020

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San Sebastián : entre el Fuero y la Constitución de 1837
Authors: García Ronda Ángel
Published: July 2020

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Los derechos individuales
Authors: Beneyto Juan
Published: July 2020

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Las primeras elecciones al Parlamento balear
Authors: Oliver Araujo Joan
Published: July 2020

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El principio de solidaridad en el Estado autonómico : sus manifestaciones jurídicas
Authors: Alonso de Antonio José Antonio
Published: July 2020

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Los grupos territoriales del Senado
Authors: García Fernández Javier
Published: July 2020

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La actividad legislativa de los Parlamentos de Cataluña y el País Vasco al final de su primera legislatura (1980-1984)
Authors: Subirats Joan
Published: July 2020

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Concreciones sobre la función estatal de alta inspección como supervisión
Authors: Vila Miranda Carmen
Published: July 2020

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Crónica parlamentaria de la Constitución de 1978
Authors: García-Atance María Victora
Published: July 2020

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Elecciones generales en Dinamarca (10 de enero de 1984)
Authors: Gómez Sánchez Yolanda
Published: July 2020

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Bibliografía jurídica sobre la organización territorial del Estado en la Constitución española de 1978
Authors: Alonso de Antonio José Antonio
Published: July 2020

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Cardiovascular Health and Risk Management in Cancer Survivors
Authors: Moslehi Javid J.
Published: July 2020

Cardio-oncology is a growing field, due to several factors. These include the recognition that similar risk factors predispose people to both cardiovascular disease and cancer. In addition, certain cancers affect the heart, and cancer treatments can have short-term and long-lasting deleterious effects on the cardiovascular system. More than 40 years ago, it became evident that anthracyclines and radiation cause heart damage, and since then the list of cancer treatments that can harm the cardiovascular system has grown to include more modern treatments, such as anti-HER2 agents and angiogenesis inhibitors. Most recently, immune checkpoint inhibitors (ICIs) have been added to the list of cancer treatments that cause cardiovascular damage. ICI-associated myocarditis is a relatively rare but fatal complication that develops rapidly after initiating immunotherapy. Oncologists should be aware of the potential cardiovascular complications of cancer treatments, and should assess the cardiovascular health of all patients about to undergo therapy. Cancer survivors should be assessed and advised about prevention and treatment that may be needed to address cardiovascular disease.
Novel and Emerging Treatment Strategies for Acute Myeloid Leukemia
Authors: Wang Eunice S.
Published: July 2020

Acute myeloid leukemia (AML) remains difficult and challenging to treat. Recognition that AML is a genomically heterogeneous disease has given rise to several new targeted therapies (eg, inhibitors of FLT3 and IDH1/2). Because the genomic landscape of AML evolves as the disease progresses, genomic testing is advised at diagnosis and at recurrence or relapse. In addition to targeted inhibitors, several emerging therapies directed at immune responses and p53 are on the horizon. Despite these advances, the 5-year overall survival rate for AML is 28.3%. The hope is that novel combinations and emerging strategies will move the survival bar higher for patients with AML in the near future.
Avaliação sustentável para instalação de aterro sanitário em uma cidade da Amazônia oriental
Authors: Sodré Giordani Rafael Conceição , Freitas Stephanie Jael Negrão de , Rodrigues Jeferson Botelho , Igawa Tassio Koiti , Amorim Islia Lima de Sousa , Cabral Ana Carla Leite Carvalho
Published: July 2020

A gestão do lixo produzido pelos centros urbanos tem sido um desafio para o Brasil. Nos últimos 20 anos, este assunto vem sendo o alvo de muitas medidas educativas, leis e diretrizes que buscam minimizar os problemas causados pela má gestão desses resíduos. Neste trabalho foi proposta uma metodologia, utilizando dados do sistema de informações geográficas e do sensoriamento remoto, com o objetivo de avaliar o território onde está localizado a cidade de Castanhal e selecionar a área que mais se ajuste as atuais normas federais de gestão do lixo urbano e de sustentabilidade. Observou-se que além da cidade manter um lixão a céu aberto, sem nenhum tratamento, o local é inadequado por estar próxima de rios, região de alagamento e casas. Em seguida, usando dos mesmos critérios que tornam a área do atual lixão imprópria, foi selecionado através da análise de terreno (relevo, hidrografia e proximidade do centro urbano) o local ideal para a instalação do projeto de aterro sanitário. Sendo este um trabalho preliminar com o objetivo de apresentar uma ferramenta simples e de baixo custo e que pode ser essencial para a tomada de decisão dos responsáveis pela gestão do lixo urbano da cidade de Castanhal.
ANNESSI: TESTI DELLE AL-FUTŪḤĀT AL-MAKKIYYA
Authors: Marconi Maurizio
Published: July 2020

En este anexo se incluye la traducción de tres capítulos de Futūḥāt al-Makkiyya, relevantes para completar el estudio del significado del yaqīn (certeza) en Ibn ʿArabī.
El Portafolio en las Ciencias de la Salud: ¿Herramienta Útil o Mantra Prescindible? Revisión Narrativa
Authors: García-Marcos Luis , García-Marcos Luis
Published: July 2020

No hay
Encuesta sobre docencia online en las Facultades de Enfermería y Medicina de la Universidad de Murcia.
Authors: Rojo Martínez José Miguel , Conesa Erragbaoui Amal Guzmán , Vera Villalba Javier , García García Miguel Ángel , Martínez de Rituerto Rey Paula , Cano Dólera Beatriz , Silvente Bernal Sara , Bernal García Antonio
Published: July 2020

Presentamos los resultados de una encuesta sobre docencia virtual realizada por las Delegaciones de Estudiantes de Enfermería y Medicina de la Universidad de Murcia. Ha sido llevada a cabo en el período de suspensión de la docencia presencial en la Universidad de Murcia, previo al período de vacaciones de primavera. En general, la percepción del estudiantado de las Facultades de Enfermería y Medicina dista de ser satisfactoria, por lo que los profesores debemos hacer un esfuerzo para intentar suplir las deficiencias en la formación de los estudiantes tras el cierre presencial de la Universidad.

We present the results of a survey on virtual teaching carried out by the Delegations of Nursing and Medicine Students of the University of Murcia (Spain). It has been carried out in the period of suspension of classroom teaching at the University of Murcia, prior to the spring break period. In general, the perception of the students of the Faculties of Nursing and Medicine is far from being satisfactory. Then, the teachers must make an effort to try to fill the deficiencies in the training of students caused by the face-to-face closure of the University.
Tres semanas de docencia virtual en la Universidad de Murcia (I): Experiencias en Medicina y Odontología
Authors: Santonja Medina Fernando , Salmerón Martínez Diego , Osuna Carrillo-Albornoz Eduardo , García-Alberola Arcadio , Sánchez Pérez Arturo , Martínez Beneyto Yolanda
Published: July 2020

Presentamos un resumen de las actividades que algunos de los profesores de la Facultad de Medicina de Murcia han llevado a cabo durante las 3 semanas previas a las vacaciones de primavera. Durante este tiempo, debido a la pandemia provocada por la COVID-19, la docencia presencial tuvo que ser sustituída por actividades en línea o virtuales, a causa de la implantación del estado de alarma en España que motivó el cierre completo de las Universidades desde el 13 de marzo de 2020. Las experiencias son de Traumatología, Matemáticas, Medicina Legal, Medicina del Sistema Cardiovascular, Periodoncia y Odontología Preventiva y Comunitaria.
Perspectives et définitions scolaires de l’identité linguistique en milieu minoritaire
Authors: Cormier Gail
Published: July 2020

Une personne bilingue ou plurilingue peut définir son identité linguistique de différentes façons. Il est particulièrement important de faire de la recherche sur les choix identitaires des adolescentes et des adolescents bilingues, car l’adolescence est une période importante de la négociation identitaire (Bourgeois, Busseri et Rose-Krasnor, 2009). Cet article explorera ainsi la manière dont les adolescentes et les adolescents manitobains, provenant de deux contextes scolaires dans lesquels le français est la langue d’enseignement, perçoivent, interprètent et définissent leur identité linguistique. Les données sont tirées d’entrevues semi-dirigées avec des élèves de trois écoles secondaires manitobaines en milieu scolaire francophone et d’immersion effectuées en 2016. Ces données révèlent que, bien que l’identité bilingue soit préférée dans tous les contextes scolaires, les élèves provenant des écoles francophones et d’immersion se diffèrent dans la façon dont ils perçoivent leurs identités linguistiques. Or, afin de répondre aux besoins des élèves, les établissements et les intervenants scolaires devraient en premier lieu mieux comprendre les choix identitaire linguistiques des élèves pour ensuite atteindre l’objectif commun de ces écoles, soit l’enseignement du français en milieu minoritaire.
Être plurilingues et francophones : représentations et positionnements identitaires d’élèves de francisation à Vancouver
Authors: Levasseur Catherine
Published: July 2020

En milieu linguistique minoritaire au Canada, où les écoles francophones accueillent une population diversifiée sur les plans culturel et linguistique, de nombreux élèves ayants droit commencent leur scolarisation avec des compétences limitées en français. Cet article vise à mettre en lumière les représentations et les positionnements identitaires de jeunes élèves plurilingues d’une école francophone de la région de Vancouver ayant reçu du soutien linguistique dans le cadre d’un programme de francisation. À partir d’une étude ethnographique de sociolinguistique menée dans une école de la région de Vancouver en 2010-2011, cet article discutera, d’une part, des représentations de l’identité francophone, telles qu’elles ont été exprimées par les élèves de francisation, et, d’autre part, de leurs efforts d’investissement ainsi que de leurs positionnements identitaires par rapport à ces représentations. Les résultats de la recherche souligneront les sentiments d’inadéquation et d’aliénation exprimés par les élèves de francisation qui se reconnaissent peu dans les représentations stéréotypées de l’identité francophone. Les expériences des élèves de francisation, considérés ici en tant que néo-locuteurs du français, illustreront les dynamiques de légitimation ayant cours en milieu scolaire et inspireront des pistes de réflexion en vue de rendre le système scolaire francophone canadien plus inclusif.
La participation en ligne en Ontario français : pistes de réflexion et d’action pour redéfinir la francophonie avec et pour les jeunes
Authors: Cotnam-Kappel Megan , Woods Heather
Published: July 2020

Cet article dresse le portrait des expériences de participation en ligne d’élèves d’écoles secondaires de langue française dans le but de redéfinir la francophonie avec les jeunes. À partir de données recueillies au moyen de questionnaires (n=215) et de groupes de discussion (n=71), nous constatons que les jeunes développent et mettent à profit une variété de compétences en littératies numériques lorsqu’ils participent en ligne. Qui plus est, nous mettons en évidence les nombreux facteurs que soupèsent les jeunes avant de publier en ligne, notamment le contenu, l’approbation, le public et les conséquences possibles. On remarque l’absence de la langue parmi ces considérations. En effet, les jeunes disent participer en français lors de communications privées ou de tâches liées à l’école, mais privilégient surtout l’anglais pour participer en ligne. Les élèves remarquent le manque d’occasions de développer leurs compétences de participation en ligne à l’école, alors que nous soulignons le potentiel de cette participation pour amener les jeunes à 1) trouver des occasions de s’exprimer et de créer en français, ainsi que de trouver des communautés francophones, et 2) s’engager dans une francophonie qu’ils redéfinissent. Nous insistons également sur l’urgence du développement de politiques et de curriculums qui touchent les littératies numériques, et la participation en ligne en particulier, pour les écoles de langue française.
El factor estético en la automatización de tareas lógicas: el caso del ajedrez
Authors: Rementeria-Sanz Santiago
Published: July 2020

Es frecuente entre los ajedrecistas expertos la apelación a características del juego consideradas artísticas. Sin embargo, y a pesar de ser el ajedrez uno de los campos más estudiados en la historia de la inteligencia artificial, han sido pocos los intentos de automatizar el juicio estético de los grandes maestros. Ha prevalecido la demanda de eficacia, recurriendo a la potencia de búsqueda de arquitecturas hardware especializadas, complementadas con métodos heurísticos y criterios de evaluación codificados manualmente. Recientemente, sin embargo, el programa AlphaZero, desarrollado siguiendo una filosofía diferente, ha sorprendido no solo por su superioridad, sino también por lo imprevisto y atractivo de algunas de sus decisiones de juego. En este artículo se repasan los criterios de belleza asumidos en la práctica del ajedrez y se analiza el modo en que AlphaZero adquiere su capacidad experta, llegando a conclusiones sobre el papel del impulso estético en la toma de decisiones racional y sobre el modo en que los sistemas artificiales pueden mostrar un comportamiento original y atractivo en actividades lógicas como el ajedrez competitivo.
Vistas panorámicas sobre el patrimonio visual colectivo a través de redes neuronales convolucionales Las exposiciones Revolutionary Arkive y Mnemosyne 2.0 de Pilar Rosado
Authors: Rosado Rodrigo Pilar , Reverter Comes Ferran
Published: July 2020

En el contexto de una sociedad saturada de imágenes, las redes neuronales convolucionales (convolutional neural networks - CNN), preentrenadas a partir de la información visual contenida en miles y miles de imágenes, constituyen una herramienta de gran utilidad para ayudarnos a ordenar el patrimonio visual, ofreciéndonos así un punto de acceso que de otra manera sería imposible.

Una de las responsabilidades del artista contemporáneo es adoptar posiciones que ayuden a dar significado, a proyectar sentido sobre la acumulación visual a la que nos enfrentamos. En este artículo pasamos a describir dos exposiciones de la artista Pilar Rosado: Revolutionary Arkive y Mnemosyne 2.0. En ellas se ha utilizado la red neuronal artificial ResNet-50 para extraer las características visuales de grandes conjuntos de imágenes y los descriptores de imagen obtenidos se han usado como entrada para el algoritmo t-SNE. Así, se han elaborado grandes mapas visuales formados por miles de imágenes ordenadas siguiendo criterios de similitud formal en los que se ponen de manifiesto los patrones visuales de los arquetipos de una determinada categoría semántica.

La manera de archivar y recuperar nuestra memoria colectiva debe tener una correlación con los avances tecnológicos y científicos de nuestra época para que se nos vayan descubriendo progresivamente nuevos horizontes de conocimiento. En su práctica artística, Rosado explora, en el ámbito de la cocreación humano-máquina, cuestiones políticas que se pueden abordar desde la imagen y que implican a las tecnologías de aprendizaje automático, como la gestión de la información en los archivos visuales del futuro o la revisión de la memoria visual colectiva.
Nomination of individuals in Bashkir language based on verbal behavior: tendency towards rudeness
Authors: Iagafarova Gul'naz Nurfayezovna , Sharafutdinova Zul'fiya Tal'gatovna , Arslanova Milyausha Synbulatovna
Published: July 2020

The object of this research is the concept of “rude person” and its expression in Bashkir language. The subject of this research is the lexical and phraseological units, representing the concept of a “rude person” in Bashkir language and its jargons. Based on the materials of definition, multilingual and dialectological dictionaries, as well as the “Electronic database of Bashkir language” the authors identify a layer of words and expressions denoting a rude person. This article presents the research on the motives for nominations of words in this topic, which allows understanding the peculiarities of the perception of human character in the language picture of the world by its native speaker based on verbal characteristics. The novelty of this research consists in the fact that for the first time in Bashkir linguistics this group of words is highlighted as a separate layer. The main conclusions of the conducted research include discovery of 45 words and expressions denoting the concept of “rude person”. The image of such person is created through lexical units of secondary nomination.
Phraseology for characteristics of personal and status position (on the example of fiction literature for teenagers)
Authors: Belozerova Ekaterina Yur'evna
Published: July 2020

This article examines the modern phraseological units in the aspect of pragmatics on the example of modern British fiction literature. Phraseology of English language being enriched with new lexical units of idiomatic character, which serve the pragmatics of expression according to narration of the text. The paper analyzes a number of modern phraseological units (phraseologisms, derivatives of phraseologisms, and authorial formulations), aimed at designation of personal or generally recognized status of heroes in the society. Authors of the analyzed literary works are the representatives of modern British linguistic community, with different life experience and views, whose work were displayed in various literary nominations and received positive assessment from the critics. All presented phraseological units are viewed in accordance to the context. The results demonstrate that the pragmatics of expression of modern phraseology is relevant not only within the framework of the described situation. Phraseological units, used for characterizing personal traits of the hero, convey his positive attitude or judgment of others, as well as cultivate formation of a certain image of the hero among audience. This research contributes to the development of principles and approaches towards studying phraseology of English language, its enrichment, and understanding of phraseology in a broader sense.
Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans
Authors: Jenkins Nicole L , James Simon A , Salim Agus , Sumardy Fransisca , Speed Terence P , Conrad Marcus , Richardson Des R , Bush Ashley I , McColl Gawain
Published: July 2020

All eukaryotes require iron. Replication, detoxification, and a cancer-protective form of regulated cell death termed ferroptosis, all depend on iron metabolism. Ferrous iron accumulates over adult lifetime in Caenorhabditis elegans. Here, we show that glutathione depletion is coupled to ferrous iron elevation in these animals, and that both occur in late life to prime cells for ferroptosis. We demonstrate that blocking ferroptosis, either by inhibition of lipid peroxidation or by limiting iron retention, mitigates age-related cell death and markedly increases lifespan and healthspan. Temporal scaling of lifespan is not evident when ferroptosis is inhibited, consistent with this cell death process acting at specific life phases to induce organismal frailty, rather than contributing to a constant aging rate. Because excess age-related iron elevation in somatic tissue, particularly in brain, is thought to contribute to degenerative disease, post-developmental interventions to limit ferroptosis may promote healthy aging.
The utilization of educational technologies: huge gap between the real and the ideal training processes in nursing education
Authors: Gadelha Marília Moreira Torres , Andrade Mayara Evangelista de , Silva Jéssica Mayara Almeida , Bezerra Isaura Carolina Brandão , Carmo Andressa Pereira do , Fernandes Marcelo Costa
Published: July 2020

Objetivo: analisar os entraves durante o percurso acadêmico no curso de Enfermagem acerca da utilização das tecnologias educativas. Métodos: pesquisa descritiva com abordagem qualitativa. Os dados foram coletados por meio de entrevistas semiestruturadas com discentes de enfermagem no período de novembro de 2016 a janeiro de 2017, sendo os depoimentos analisados através da análise de discurso. Resultados: os discentes discursaram como entraves o fato dos docentes permanecerem fincados no método tradicional de ensino; a falta de interesse em levar essas tecnologias para o ambiente de ensino, além da formação dos próprios educadores serem focadas em um ensino com metodologias tradicionais. Conclusão: surge a necessidade de discutir sobre o papel da gestão e a formação pedagógica necessária para a efetividade da docência em saúde, que, mesmo com todas as diretrizes norteadoras e reestruturadoras desse ensino, não garantem a formação do profissional com o perfil pretendido.
Práticas religiosas no espaço cemiterial: observações sobre o Cemitério do Bonfim
Authors: Almeida Marcelina das Graças de , Santana Julio Cesar de Aguiar , Silva Roberto Fernandes da
Published: July 2020

O propósito do artigo é apresentar evidências que permitam a compreensão dos espaços cemiteriais como lugares de manifestação de experiências religiosas diversas. O Cemitério do Bonfim, situado na cidade de Belo Horizonte, no Estado de Minas Gerais, foi escolhido para apontar algumas dessas evidências. Trata-se de uma necrópole inaugurada no final do século XIX, sob a égide da instalação do pensamento republicano enquanto um cemitério laico. A despeito desse caráter, o cemitério foi palco de diversas construções e práticas religiosas, desde sua fundação até a atualidade, perpassadas pelos cultos afro-brasileiros; pela mística católica, por meio do culto ao túmulo do Padre Eustáquio; bem como ponto de referência para adeptos do Espiritismo, por intermédio do túmulo dedicado à memória de Irma de Castro Rocha, a Meimei.