bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel Immunotherapeutic Agent for the Treatment and Prevention of Staphylococcal Mastitis in Dairy Cows
Authors: Leitner Gabriel , Balaban Naomi
Published: March 2022

Staphylococci are the most common and costly mammary disease of dairy cattle worldwide. TRAP, a membrane associated 167AA protein, is highly conserved among staphylococci. The aims of this study were to test the safety and efficacy of recombinant TRAP (rTRAP) vaccine in dairy animals. The vaccine was safe as 2-3 subcutaneous injections of rTRAP (54–100μg) with adjuvant ISA 206 to cows and goats did not lead to any abnormal symptoms of sensitivity to the vaccine. The rTRAP vaccine was immunogenic and caused the induction of a humoral immune response that remained high for at least 160 days post second immunization. rTRAP vaccine also elicited a cell-mediated immune response (memory CD4+ and CD8+ T cells), as determined by lymphocyte proliferation assays. The rTRAP vaccine was efficacious as at parturition, only 13.5% heifers in the immunized group were infected with Staphylococcus chromogenes as compared to 42.9% in the non immunized group. Additionally, when cows were immunized in mid-lactation, the difference between somatic cell count (SCC) in immunized and control animals was profound (45±7 vs. 470±194, respectively). At the same time, the difference in milk yield was also evident (48.3±1.4 vs. 44.3±0.9 l/day, respectively). Put together, these studies indicate the value of the rTRAP vaccine in preventing new udder infections by staphylococci, which significantly lead to lowered SCC and some increase in milk yield. TRAP is conserved among all strains and species and is constitutively expressed in any strain of S. aureus or CNS tested so far, including those isolated from cows. TRAP may thus serve as a universal anti-staphylococcus vaccine.
Mechanism of Internal Initiation of Translation in Plants
Authors: Elroy-Stein Orna , Belostotsky Dmitry
Published: March 2022

Original objectives Elucidation of PABP's role in crTMV148 IRES function in-vitro using wheat germ extract and krebs-2 cells extract. Fully achieved. Elucidation of PABP's role in crTMV148 IRES function in-vivo in Arabidopsis. Characterization of the physical interactions of PABP and other potential ITAFs with crTMV148 IRES. Partly achieved. To conduct search for additional ITAFs using different approaches and evaluate the candidates. Partly achieved. Background of the topic The power of internal translation via the activity of internal ribosomal entry site (IRES) elements allow coordinated synthesis of multiple gene products from a single transcription unit, and thereby enables to bypass the need for sequential transformation with multiple independent transgenes. The key goal of this project was to identify and analyze the IRES-trans-acting factors (ITAFs) that mediate the activity of a crucifer-infecting tobamovirus (crTMV148) IRES. The remarkable conservation of the IRES activity across the phylogenetic spectrum (yeast, plants and animals) strongly suggests that key ITAFs that mediate its activity are themselves highly conserved. Thus, crTMV148 IRES offers opportunity for elucidation of the fundamental mechanisms underlying internal translation in higher plants in order to enable its rational manipulation for the purpose of agricultural biotechnology. Major conclusions and achievements. - CrTMV IRES requires PABP for maximal activity. This conclusion was achieved by PABP depletion and reconstitution of wheat germ- and Krebs2-derived in-vitro translation assays using Arabidopsis-derived PABP2, 3, 5, 8 and yeast Pab1p. - Mutations in the internal polypurine tract of the IRES decrease the high-affinity binding of all phylogenetically divergent PABPs derived from Arabidopsis and yeast in electro mobility gel shift assays. - Mutations in the internal polypurine tract decrease IRES activity in-vivo. - The 3'-poly(A) tail enhances crTMV148 IRES activity more efficiently in the absence of 5'-methylated cap. - In-vivo assembled RNPs containing proteins specifically associated with the IRES were purified from HEK293 cells using the RNA Affinity in Tandem (RAT) approach followed by their identification by mass spectroscopy. - This study yielded a list of potential protein candidates that may serve as ITAFs of crTMV148 IRES activity, among them are a/b tubulin, a/g actin, GAPDH, enolase 1, ribonuclease/angiogenin inhibitor 1, 26S proteasome subunit p45, rpSA, eEF1Bδ, and proteasome b5 subunit. Implications, both scientific and agriculture. The fact that the 3'-poly(A) tail enhances crTMV148 IRES activity more efficiently in the absence of 5'-methylated cap suggests a potential joint interaction between PABP, the IRES sequence and the 3'-poly(A). This has an important scientific implication related to IRES function in general.
Replication Defective Cyprinid Herpes Virus-3 (CyHV-3) as a Combined Prophylactic Vaccine in Carps
Authors: Kotler Moshe , Hanson Larry , Burgess Shane
Published: March 2022

Aquacultured koi and common carp fish (Cyprinus carpio) are intensively bred as ornamental and food fish in many countries worldwide. Hatcheries of carp and koi have recently suffered massive financial damages due to two viral diseases caused by the Cyprinid herpesvirus-3 (CyHV-3), previously designated as Carp Interstitial Nephritis and Gill Necrosis Virus (CNGV) and Koi herpesvirus (KHV), and by the Spring Viremia of Carp Virus (SVCV). CyHV-3 is a large dsDNA virus, which is infectious mostly to koi and common carp, while SVCV is a rhabdovirus with a relatively broad host range. Both viruses induce contagious disease with mortality rate up to 90%.   Strategies for the control of viral infection in fish are of limited use. While efforts to prevent introduction of infectious agents into culture facilities are desirable, such exclusion strategies are far from fail-safe. Extensive vaccination methods that are useful for use in aquaculture facilities produce weak immunity, when used with proteins or inactivated viruses.  Methods to overcome this obstacle are to vaccinate the fish with large amounts of antigen and/or use adjuvant and immune modulators over a long period. These techniques usually require individual handling of the fish.  On the other hand, live attenuated virus is efficient and economical when used as an immersionvaccine.  However, this technique poses certain environmental risks and thus may be difficult to license and scale up.  Another option is a vaccine based on the replication defective virus (RDV) (pseudovirus), which can infect cells, but is unable to produce infectious particles. This vaccine may circumvent many of the problems related to attenuated-live vaccine (e.g., inadvertent infection and reversion to the virulent strain).
Structure, Function and Utilization of Plant Photosynthetic Reaction Centers
Authors: Nelson Nathan , Yocum Charles F.
Published: March 2022

Light capturing and energy conversion by PSI is one of the most fundamental processes in nature. In the heart of these adaptations stand PSI, PSII and their light harvesting antenna complexes. The main goal of this grant proposal was to obtain by X-ray crystallography information on the structure of plant photosystem I (PSI) and photosystem II (PSII) supercomplexes. We achieved several milestones along this line but as yet, like several strong laboratories around the world, we have no crystal structure of plant PSII. We have redesigned the purification and crystallization procedures and recently solved the crystal structure of the PSI supercomplex at 3.3 Å resolution. Even though this advance in resolution appears to be relatively small, we obtained a significantly improved model of the supercomplex. The work was published in J. Biol. Chem. (Amunts et al., 2010). The improved electron density map yielded identification and tracing of the PsaK subunit. The location of an additional 10 ß-carotenes, as well as 5 chlorophylls and several loop regions that were previously uninterruptable have been modeled. This represents the most complete plant PSI structure obtained thus far, revealing the locations of and interactions among 17 protein subunits and 193 non-covalently bound photochemical cofactors. We have continued extensive experimental efforts to improve the structure of plant PSI and to obtain PSII preparation amenable to crystallization. Most of our efforts were devoted to obtain well-defined subcomplexes of plant PSII preparations that are amenable to crystallization. We studied the apparent paradox of the high sensitivity of oxygen evolution of isolated thylakoids while BBY particles exhibit remarkable resilience to the same treatment. The integrity of the photosystem II (PSII) extrinsic protein complement as well as calcium effects arise from the Ca2+ atom associated with the site of photosynthetic water oxidation were investigated. This work provides deeper insights into the interaction of PsbO with PSII. Sight-directed mutagenesis indicated the location of critical sites involved in the stability of the water oxidation reaction. When combined with previous results, the data lead to a more detailed model for PsbO binding in eukaryotic PSII.
Use of Branding and Sampling in Agricultural Fresh Produce
Authors: Zilberman David , Heiman Amir , Jin Yanhong
Published: March 2022

The original proposal has three main objectives: a conceptual framework on willingness to pay (WTP) for fruits and vegetables, the introduction of branding and sampling in fresh food, and empirical applications to the United States and Israel. We modified our research plan over time based on availability of data and emergence of new problems. We expanded the range of products to include poultry and the range of techniques to use real experiments as well as more traditional surveys. We expanded the range of problems to understand attitudes toward genetically modified (GM) food.   There is a growing interest in introduction of marketing tools like demonstration sampling, money-back guarantees, labeling, and brands in agriculture. These marketing tools are important for enhancing demand for agricultural products and food safety. However, the methodology needed to assess the effectiveness of these tools and understand their performance in different agricultural sectors is limited.   Our analysis demonstrated the importance of brands as a marketing tool in agriculture. In particular, we showed conceptually that strong brands can be substitutes for other marketing tools like sampling or demonstration. We were able to conduct real experiments for the demand for safe chicken and show that consumers are willing to pay significantly more for products branded as more safe. Yet, using experiments in Israel and the United States, we found that WTP for brands of fresh fruits and vegetables is smaller than in other product categories.   Warning labels are a sort of negative branding. The GM-free labeling is particularly important since it serves as a trade barrier to U.S. crops exports. Our analysis of acceptance of GM products found that WTP for GM products in Israel and the United States depends on framing of information about the impact ofGM and the quantity of information disclosed. Finally, in analyzing the evolution of support for Proposition 37 that aimed to introduce mandatory labeling of GM in California, we found that support for mandatory labeling ofGM products is broad as long as it is not perceived to be costly.   Our project demonstrates the feasibility of conducting real experiments to assess consumer demand in agriculture. When looking at interdisciplinary groups, one can design new products and assess the WTP for their characteristics. We also show that, while branding is a very strong marketing tool, its use in fresh fruit and vegetables is likely to be limited. However, brands can be important with processed food. Furthermore, we have proven that, while some consumers strongly object to GM products, most consumers in the United States and Israel would be willing to buy them for a discount, and some would pay extra if they are associated with improved characteristics. Finally, we expanded the notion of warning labels to calorie information and showed that the response to calorie information depends on gender, education, and how the information is presented.
Development of Fish Edible Vaccines on the Yeast and Redmicroalgae Platforms
Authors: Vakharia Vikram , Arad Shoshana , Zohar Yonathan , Weinstein Yacob , Yusuff Shamila , Ammayappan Arun
Published: March 2022

Betanodaviruses are causative agents of viral nervous necrosis (VNN), a devastating disease of cultured marine fish worldwide. Betanodavirus (BTN) genome is composed of two single-stranded, positive-sense RNA molecules. The larger genomic segment, RNA1 (3.1 kb), encodes the RNA-dependent RNA polymerase, while the smaller genomic segment, RNA 2 (1.4kb), encodes the coat protein. This structural protein is the host-protective antigen of VNN which assembles to form virus-like particles (VLPs). BTNs are classified into four genotypes, designated red-spotted grouper nervous necrosis virus (RGNNV), barfin flounder nervous necrosis virus (BFNNV), tiger puffer nervous necrosis virus (TPNNV), and striped jack nervous necrosis virus (SJNNV), based on phylogenetic analysis of the coat protein sequences. RGNNV type is quite important as it has a broad host-range, infecting warm-water fish species. At present, there is no commercial vaccine available to prevent VNN in fish. The general goal of this research was to develop oral fish vaccines in yeast and red microalgae (Porphyridium sp.) against the RGNNV genotype. To achieve this, we planned to clone and sequence the coat protein gene of RGNNV, express the coat protein gene of RGNNV in yeast and red microalgae and evaluate the immune response in fish fed with recombinantVLPs antigens produced in yeast and algae.   The collaboration between the Israeli group and the US group, having wide experience in red microalgae biochemistry, molecular genetics and large-scale cultivation, and the development of viral vaccines and eukaryotic protein expression systems, respectively, was synergistic to produce a vaccine for fish that would be cost-effective and efficacious against the betanodavirus infection.
A influência da dança na aprendizagem escolar
Authors: Martins Vanéria Paula Sousa
Published: March 2022

Embora a dança seja considerada como uma manifestação corporal presente no processo da civilização humana desde tempos remotos e de suma importância no processo educacional, apenas o básico não tem sido sendo suficiente para garantir o seu ensino escolar. O conteúdo dança nas escolas deve persuadir as pessoas sobre os benefícios que ela propicia ao educando. Ao indagar sobre a dança no desenvolvimento do aluno, surge um questionamento se: A dança pode melhorar a aprendizagem dos alunos na escola? O estudo teve como objetivo principal estudar a influência que a dança pode exercer sobre o comportamento e formação das pessoas, e analisar se a dança pode realmente contribuir para a melhoria da aprendizagem do aluno. A pesquisa foi de natureza qualitativa, do tipo bibliográfico. O estudo mostrou que a dança pode melhorar a aprendizagem, o comportamento social dos alunos, desenvolvendo aspectos motores e cognitivos, que levam à cidadania moral, moldando suas perspectivas e ideias.
Research on the Attitudes of Breast Specialist Medical Staff Towards the Implementation of Breast Cancer Decision-Making Aids
Authors: Gao Jinping , Huang Zhong-qin , Chen Xue-ya , Li Dong-zhi , Wu Wang-feng , Liu Rong-rong
Published: March 2022

Background: The participation of patients in treatment and nursing decision-making has been advocated by many medical staff. This is not only to attach importance to the wishes of patients, but also to the needs of social development. The purpose of this research was to investigate the attitudes of Chinese breast cancer medical staff towards the implementation of breast cancer decision-making aids.Methods: A cross-sectional study was conducted among 420 doctors and nurses in the Department of Breast Surgery. We used a questionnaire designed by investigators. Data was collected from February 2021 to September 2021. IBM SPSS Version 22 was used to analyze the collected data.Results: Overall, 420 valid questionnaires were returned from 220 doctors and 200 nurses. Response rate was 85.19%. The results showed that 77.14% of the medical staff supported the promotion of breast cancer decision-making aids, and 85.71%（360/420）agreed that patients should be the main participants in high-quality clinical decision-making. Also, 95.24%（400/420）believed that patients should know the reasons for making treatment decisions, and agreed that the positive effects of patient decision-making aids were positively correlated with high education (r education=0.317, P=0.001). There were statistically significant differences in the attitudes of medical staff with different working years (X2=9.432, P=0.024), educational background (X2=42.918, P<0.001) and shared decision education (X2=11.932, P=0.008) on whether to promote decision-making aids. Conclusion: At this stage, breast medical staff have a positive attitude towards using breast cancer decision aids for joint decision-making.
Effectiveness of Positive Thinking Training on Perceived Stress, Metacognitive Beliefs, and Death Anxiety in Women with Breast Cancer
Authors: Kianpour Barjoee Laleh , Amini Naser , Keykhosrovani Moloud , Shafiabadi Abdollah
Published: March 2022

Background: Women with breast cancer suffer high levels of stress due to their disease-induced emotional, cognitive, behavioral and physical problems which increase their metacognitive beliefs, death anxiety, and rumination, disrupt the treatment process, and exert a negative impact. The present study aimed to investigate the effectiveness of positive thinking training on perceived stress, metacognitive beliefs, and death anxiety in women with breast cancer in Ahvaz in 2019.

Methods: This was a quasi-experimental study with pretest-posttest control group design. Statistical population consisted of all women with breast cancer visiting Shafa Health Center of Ahvaz in 2019, among whom 30 women were selected as the sample using convenience sampling. Cancer patients were randomly divided into intervention (n=15) and control (n=15) groups. The research instruments included the Perceived Stress Scale, the Metacognitions Questionnaire (MCQ-30), and the Scale of Death Anxiety (SDA). Univariate and multivariate analysis of covariance were used to analyze data.

Results: Results suggested that positive thinking training reduced perceived stress, metacognitive beliefs and death anxiety in women with breast cancer in the intervention group compared with those in the control group (P<0.001).

Conclusion: According to the results of the study, positive thinking training was effective in reducing perceived stress, metacognitive beliefs, and death anxiety in women with breast cancer.
Líneas de ayudas al sector del comercio en el marco del Plan de Recuperación, Transformación y Resiliencia y de los fondos Next Generation EU
Authors: Apoyo a la Competitividad del Pequeño Comercio Subdirección General de
Published: March 2022

El Ministerio de Industria, Comercio y Turismo, a través de la Secretaría de Estado de Comercio, ha establecido las líneas de ayudas al sector del comercio en el marco del Plan de Recuperación, Transformación y Resiliencia y de los fondos Next Generation EU que se incardinan en el Componente 13, Impulso a la pyme, con el objetivo de reforzar la cohesión social y territorial y mejorar la competitividad del sector del comercio, apostando por un modelo más digital y sostenible. La inversión a realizar dentro del concepto «Modernización de mercados municipales y áreas comerciales» tiene una dotación de 200 millones de euros y la dedicada a “Impulso de la actividad comercial en zonas rurales” tiene una dotación de 15 millones de euros. Ambas se desarrollarán en el periodo 2021-2023. La línea de ayudas para el fortalecimiento de la actividad comercial en zonas de gran afluencia turística se encuentra recogida en el Componente 14, "Plan de modernización y competitividad del sector turístico", para la financiación de proyectos de impulso a la competitividad, innovación y modernización de la oferta comercial ligada a la llegada de visitantes a los municipios turísticos. La inversión tiene una dotación de 100 millones de euros para el periodo 2021-2023.Una cuarta línea de ayudas denominada “Fondo tecnológico para el comercio” se orienta a pymes del sector comercial que podrán presentar sus proyectos, de manera individual o a través de sus asociaciones de comerciantes, con el objetivo de incorporar nuevas tecnologías al comercio local impulsando su transformación digital y sostenibilidad. Este fondo, integrado en el Componente 13, tiene una dotación de 100 millones de euros, para 2022 y 2023.
KEMAMPUAN MEMBACA PERMULAAN ANAK MELALUI METODE BERMAIN KARTU HURUF (Usia 5 � 6 Tahun Di Paud Tunas Bangsa Kelurahan Sindangsari Kecamatan Bogor Timur)
Authors: . Masitowati , Rahmaniah R. Siti Sopiah
Published: March 2022

Penelitian ini bertujuan untuk meningkatkan kemampuan membaca permulaan melalui� metode permainan kartu huruf anak usia 5-6 tahun di PAUD Tunas Bangsa Kelurahan Sindangsari Kecamatan Bogor Timur. Jenis penelitian ini adalah penelitian tindakan kelas
kolaboratif dengan menggunakan model penelitian Kemmis dan Mc. Taggart dengan dua siklus, setiap siklusnya tiga kali pertemuan. Objek penelitian berfokus pada peningkatan kemampuan membaca permulaan melalui metode bermain kartu huruf. Metode pengumpulan data menggunakan observasi checklist, dan dokumentasi. Data dianalisis menggunakan teknik deskriptif kualitatif dan kuantitatif. Hasil penelitian menunjukkan
bahwa terjadi peningkatan kemampuan membaca permulaan sebesar 16,28% pada akhir siklus I dan pada akhir siklus II mengalami peningkatan sebesar 17,97%. Peningkatan kemampuan membaca permulaan ini terlihat dari anak sudah mampu mampu mengurutkan huruf abjad, mampu menyebutkan lambang atau simbol huruf vokal, mampu menyebutkan
lambang atau simbol huruf konsonan, mampu membaca suku kata berpola KV (Konsonan Vokal), mampu membaca suku kata berpola VK (Vokal Konsonan), mampu membaca suku kata berpola KVK (Konsonan, Vokal, Konsonan), mampu menyebutkan kata yang mempunyai fonem awal yang sama, serta mampu menyusun huruf menjadi kata sesuai dengan gambar
yang ditunjukkan.
MODEL EVALUASI SIARAN RADIO PENDIDIKAN FKIP UIKA
Authors: Efgivia Mohammad Givi , Supriadi Dedi
Published: March 2022

Radio Pendidikan Streaming FKIP UIKA sebagai salah bentuk media
pembelajaran, dalam kajian ini untuk mengetahui :a) Evaluasi Siaran Radio b)
Metode siaran untuk radio pendidikan c) strategi evaluasi untuk radio
pendidikan. Dalam penelitian ini menggunakan metode Deskriftif. Kajian ini
dilakukan produksi program selesai dengan melakukan survey serta dialog
terbatas dan terarah. Tentang hal strategi evaluasi siaran radio pendidikan
streaming FKIP UIKA ialah dengan mengumpulkan / melibatkan pendengar
dengan melibatkan pakar keradioan guna melihat perkembangan dan
mengidentifikasikan aspek sasaran pendengar, observasi pendengar, data
pendengar, temu pendengar, suvey pendengar dan bukti survey. Hasil
Evaluasi menemukan adalah evaluasi dalam siaran radio berguna dilakukan
pengkajian kembali berguna untuk usulan program yang sudah terprogram
serta mengetahui kesuksekan siaran dan kekurangan dalam sebuah program
PENGEMBANGAN MODEL PEMBELAJARAN DISCOVERY LEARNING PADA MATA KULIAH PERKEMBANGAN KEPRIBADIAN MAHASISWA AMIK DCC BANDAR LAMPUNG
Authors: Hidayah Tsamaniariaty , Syafitri Yuli
Published: March 2022

Penelitian ini bertujuan untuk: 1) menganalisis kondisi dan potensi, 2)
menganalisis proses, 3) menganalisis karakteristik model pembelajaran discovery
learning, 4) meningkatkan efektifitas, 5) meningkatkan efisiensi, dan 6)
meningkatkan daya tarik dengan menggunakan model pembelajaran discovery
learning untuk meningkatkan kepribadian. Penelitian ini merupakan Research and
Development (R&D). Data dikumpulkan dengan angket, tes dan observasi serta
dianalisis secara deskriptif kualitatif. Hasil penelitian ini adalah: 1) pembelajaran
yang digunakan kurang bervariasi, 2) proses pembelajaran discoveri learning
dilakukan dengan cara dosen menyajikan informasi awal kepada mahasiswa
sebelum kegiatan pembelajaran dimulai, 3) langkah model pembelajaran discovery
learning adalah analisis kebutuhan, desain pembelajaran, desain dan
pengembangan media, validasi ahli dan revisi, uji coba dan revisi, uji coba
lapangan, 4) meningkatnya efektifitas pembelajarannya menggunakan model
pembelajaran discoveri learning lebih besar, 5) meningkatnya efisiensi melihat dari
waktu pembelajaran yang dilakukan, dan 6) meningkatnya daya tarik yang tinggi
sehingga memiliki dampak positif terhadap perubahan kepribadian mahasiswa
PENGARUH KECERDASAN EMOSIONAL TERHADAP PRESTASI BELAJAR WARGA BELAJAR PKBM AL-FATTAH
Authors: Novianti Sindi , Romi Romi
Published: March 2022

Penelitian ini bertujuan untuk mengetahui pengaruh kecerdasan emosional terhadap prestasi belajar warga belajar PKBM Al-Fattah. Kecerdasan emosional merupakan kesadaran diri, pengaturan diri, motivasi diri, empati dan keterampilan sosial sehingga perlu diketahui pengaruhnya terhadap prestasi belajar. Penelitian ini menggunakan pendekatan kuantitatif dengan metode angket. Hasil penelitian menunjukan bahwa variabel kecerdasan emosional (X) berpengaruh terhadap variabel prestasi belajar (Y), dan pengaruh variabel bebas (kecerdasan emosional) terhadap variabel terikat (prestasi belajar) adalah sebesar 59.6%. Sedangkan sisanya sebesar 40.4% merupakan kontribusi variabel lain yang tidak termasuk dalam model.
The Translation Analysis of Illocutionary Change in Jojo Moyes’ The Last Letter from Your Lover Novel Translation into Indonesian
Authors: Dian Indrawati  , Wibowo Agung Prasetyo
Published: March 2022

Translation is crucial to effective communication between different languages and conveys meaning from one language to another. It can enlarge knowledge about all languages in all parts of the world. Through the techniques and strategies in the translation, there would be no difficulty in understanding a text in a certain language. In the process of translation, a change in structures or elements of a certain language might exist. The structures in every language are unique, and this is often a challenge for a translator to comprehend them. That’s why the researcher is interested in conducting this research. The scope of this research is an Illocutionary change strategy, especially on the application or the changes in the text due to the use of this strategy. This research is conducted to obtain factual data of illocution change in the translation of the sourcebook and analyze the translation results in order to convey the meaning from the source language. The result of this research is crucial to prevent the confusion of understanding the translation result meaning in the target language, especially for the target language readers or learners. Another significance of this research is to add knowledge for those interested in learning the translation. This research uses the qualitative method. The data analysis technique is based on the translation results or the closest equivalence in Indonesian. The results of the analysis show that there is an Illocutionary change strategy that is used by the translator, and certain categories in the translation results are found.
TURİZM İŞLETMELERİNDE SÜRDÜRÜLEBİLİRLİK VE İKLİM DEĞİŞİKLİĞİ İLE MÜCADELE: BİR MODEL ÖNERİSİ (SUSTAINABILITY AND TACKLING CLIMATE CHANGE IN TOURISM ENTERPRISES: A MODEL PROPOSAL)
Authors: TEKİN Zeliha , USLU Ferit
Published: March 2022

Çalışmanın amacı, sürdürülebilirliğin sağlanmasına yönelik olarak dünyadaki ve Türkiye’deki turizm işletmelerinin iklim değişikliği ile mücadelede hangi çalışmaları yaptıklarının ve hangi yönetimsel araçları ve stratejileri kullandıklarının tespit edilmesi ve turizm işletmeleri için bir model önerilmesidir. Bu amaçtan hareketle, alan yazın taranmış, iklim değişikliği ile mücadele çalışmaları yürüten turizm işletmelerinin web sayfaları incelenmiş ve turizm işletmelerinin çevreye duyarlılığı temsil eden mavi bayrak, yeşil yıldız, yeşil tur, yeşil otel, yeşil turizm işletmesi gibi sertifikasyonlara yönelmeye başladığı (hem müşterilerin bu yöndeki talepleri doğrultusunda hem de işletmelerin yarına kalamama endişelerinden dolayı) sonucuna varılmıştır. Ayrıca, sayılan bu sertifikalara sahip olan turizm işletmelerinin su ve enerji tasarrufu sağladıkları, etkin bir atık yönetimi uyguladıkları, yenilenebilir enerji kaynaklarına yöneldikleri, geri dönüşümlü maddeleri kullanmaya özen gösterdikleri, yatırıma gitmeden ve işletme/tesis kurmadan önce çevre analizleri yaptıkları tespit edilmiştir.
Particle Size Effect on DEM Simulation of Pressures Applied on a Cylindrical Silo with Hopper
Authors: Houhamdi Sami , Gallego Vazquez Eutiquio , Djeghaba Kamel
Published: March 2022

This work is a contribution to the comprehension of the particle upscaling effect on DEM simulation of cylindrical silos. Three silo models have been simulated with different hopper outlets and inclination angles. Huge calculations of 11 simulation series with a different scaling factor are considered for every model. Pressures applied on silo walls remain quite identical with particle upscaling. Besides, their curves are in agreement with Eurocode standard. The computing time is significantly reduced as well as the number of particles, where the simulation speed is increased up to 12 times by just scaling particle radius two times. The total bulk density was not affected by particle escalation and its value remains unchanged.
Osallistuva taidelähtöinen tutkimus aktiivisen kansalaisuuden rakentajana ja vahvistajana
Authors: Martikainen Jari
Published: March 2022

Aktiivisen kansalaisuuden tietoja ja taitoja voidaan oppia niin koulutusorganisaatioissa kuin informaaleissa yhteisöllisen osallistumisen tilanteissa. Millainen areena osallistuva taidelähtöinen tutkimus on aktiivisen kansalaisuuden ja ekososiaalisen sivistyksen oppimiselle ja toteuttamiselle?
Opinnäytetyö haastaa ja palkitsee
Authors: Vanhanen-Nuutinen Liisa
Published: March 2022

Jokaisella yliopistolla ja ammattikorkeakoululla on omat ohjeensa opinnäytetyöhön. Ne auttavat ja tukevat ohjaajaa jaopiskelijaa, jäsentävät työprosessia ja yhtenäistävät korkeakoulun opinnäytetyökäytäntöjä ja arviointia. Ohjeissa määritelläänvaihtoehtoiset opinnäytetyypit, jotka samalla viitoittavat työn metodologisia lähtökohtia ja valintoja. Lisäksi tarvitaan juuri opinnäytteen tekemiseen suunnattua tutkimusmenetelmäkirjallisuutta. Näin onnistut opinnäytetyössä vastaa juuri tähän tarpeeseen.
Summaries
Authors: Clarke Sario Esko , Foster Raisa
Published: March 2022

Tiedeartikkelien englanninkieliset käännökset.
Pengukuran Tingkat Risiko Terhadap Kapabilitas Tata Kelola Teknologi Informasi Berdasarkan Framework COBIT 5
Authors: Ambarita Rumondang Martha , Cholil Widya
Published: March 2022

Pengukuran tingkat kapabilitas tata kelola teknologi informasi dibutuhkan untuk mengetahui kondisi tata kelola teknologi informasi perusahaan saat ini. Penerapan tata kelola teknologi informasi tidak lepas dari kemungkinan adanya risiko teknologi informasi sehingga diperlukan sebuah framework yang dapat digunakan untuk mengukur tingkat kapabilitas tata kelola teknologi informasi, serta dapat digunakan sebagai pedoman pengukuran tingkat risiko dan perumusan mitigasi risiko. Tingkat kapabilitas teknologi informasi diukur berdasarkan metode Process Assesment Model (PAM) yang ada pada COBIT 5. Pengukuran tingkat kapabilitas dilakukan pada dua proses COBIT 5 yaitu EDM03 Ensure Risk Optimization dan APO12 Manage Risk. Identifikasi risiko dilakukan berdasarkan hasil pengukuran tingkat kapabilitas, di mana diperoleh empat potential risk yang kemudian diukur berdasarkan COBIT 5 for Risk. Hasil pengukuran tingkat risiko untuk potential risk 1, potential risk 2, dan potential risk 4 berada pada level medium, sedangkan potential risk 3 berada pada level low. Hasil yang diperoleh dari pengukuran tingkat risiko untuk keempat potential risk tersebut digunakan sebagai dasar untuk merumuskan rekomendasi langkah – langkah mitigasi risiko.
Perancangan Sistem Informasi Penjualan Ayam Negri Berbasis Aplikasi Android Di Cv.Suyadi Broiler
Authors: Fauzi Muhamad , Murti Hari
Published: March 2022

Peternak Ayam suyadi broiler adalah suatu badan usaha yang bergerak dibidang penjualan ayam broiler, Peternak Ayam Bapak Suyadi merupakan tempat pemotongan sekaligus juga peternakan ayam broiler yang sudah berdiri sejak 2013 dan beralamat di Jl.Nglaran Rt 004/011, Ngalang Gedangsari, Gunungkidul yogyakarta. Selama ini dalam melakukan pendataan penjualan dan pembayaran masih dilakukaan secara manual hanya menggunakan nota pembelian saja untuk orderan dari pembelian skala besar, sedangkan untuk pembeli eceran skala kecil tidak menggunakan nota. Beberapa kesulitan yang dihadapi adalah kesulitan dalam melakukan pengecekan stok ayam hanya mengira-ngira bobot ayam yang kiranya akan diorder, dan juga rekap pembayaran yang masih ditulis dalam buku nota menjadikan banyaknya permasalahan dalam penjumlahannya yang terkadang tidak sesuai. Untuk membantu proses pendataan dan pelaporan hasil penjualan dibutuhkan suatu sistem, maka dibuatlah aplikasi penjualan dan pendataan hasil penjualan ayam broiler berbasis android. Dalam pembuatan aplikasi ini menggunakan android studio dan menggunakan metode pengembangan sistem waterfaall sedangkan dalam pembuatan database dengan menggunakan MySQL. Dalam mengimplementasikannya dengan beberapa sourcode yang menjadikan suatu program sistem informasi penjualan dapat mempermudah pelanggan mengakses sistem yang telah dibuat adapun dengan metode waterfaall dapat mempermudah melakukan suatu perancangansistem dan menggunakan database sebagai tempat/wadah untuk menampung data user maupun data pengolahan. Dalam melakukan penelitian ini dapat dilihat dengan hasil aplikasi penjualan dan pendataan penjualan ayam yang terdapat beberapa fitur yaitu yang pertama ada order yang dapat memesan secara online yang nantinya akan diproses sistem akan mengirimkan notifikasi ke kurir kemudian kurir nantinya akan mengirimkan pesanan kita adapuan memesan secara langsung, yang kedua ada pembayaran yang menggunakan fitur pembayaran langsung, melalui payment, dan menggunakan transfer bank/virtual account, dan yang ketiga terdapat fitur kurir untuk mengantarkan orderan dari pemesanan secara online melalui aplikasi, sistem ini dapat digunakan dengan mudah oleh pengguna maupun dari pemilik peternakan yang disebut juga dengan user admin dalam aplikasi. Dengan adanya sistem ini diharapkan dapat menunjang kinerja pada penjualan bapak suyadi, memudahkan mengelola data pembelian dan penjualan.Kata kunci : Peternakan Suyadi Broiler, Sistem penjualan, Aplikasi Android, MySQL, Waterfall
Perfil bioquímico e significado clínico de genes da via MAPK/KINASE no diagnóstico de neoplasias de tireoide
Authors: Santos Joyce Nascimento , Silva Raissa Monteiro da , Bhattacharjee Tanmoy Tapobrata , Kulcsar Marco Aurélio Vamondes , Uno Miyuki , Chammas Roger , Canevari Renata de Azevedo
Published: March 2022

As neoplasias da tireoide são os principais tipos de malignidade endócrina, apresentando incidência aumentada nos últimos anos. O diagnóstico de rotina pode apresentar resultados inconclusivos, levando à necessidade de utilização de técnicas adicionais mais precisas, tais como a análise molecular. Portanto, é essencial a busca de marcadores moleculares para o diagnóstico dessas neoplasias e seus diferentes tipos histológicos. O objetivo deste estudo foi identificar marcadores moleculares diagnósticos para carcinoma papilífero de tireoide (CPT) e lesões de bócio. Para isso, a expressão de genes pertencentes à via MAPK/KNASE foi avaliada pela técnica de RT-qPCR. Adicionalmente, perfis bioquímicos completos das amostras foram obtidos por meio da espectroscopia de infravermelho com transformada de Fourier (FTIR). Os resultados do RT-qPCR sugerem que os genes FOS, JUN, MAP2K6, CCNA1, SFN têm o potencial de serem marcadores tumorais de lesões da tireoide, e os genes MAP2K6, CCNA1, SFN têm ainda o potencial de distinguir amostras de CPT de outras lesões de tireoide. Os resultados do FTIR mostraram que as lesões de CPT podem ser diferenciadas de tecidos normais e benignos com 95,83% de eficiência; sendo as alterações nos ácidos nucleicos o principal fator de classificação. No geral, os resultados sugerem o potencial da análise molecular e do FTIR no diagnóstico do câncer de tireoide.
Experiência do adoecimento por câncer de próstata: interface com a masculinidade na perspectiva de Pierre Bourdieu
Authors: Pinto Bruna Knob , Muniz Rosani Manfrin , Bisognin Elisiane , Schek Gabriele , Mix Paulo Roberto , Zorzan Rosa Maria
Published: March 2022

A masculinidade na sociedade atual incorpora os processos históricos e culturais transgeracionais. Expressões cotidianas como “homem de verdade não adoece”, “homem que é homem não sente dor”, “procurar médico é coisa de mulher” são propagadas na retórica popular e retratam exigências sociais consideradas como partes constituintes da essência masculina que demonstram autonomia, força, comportamentos de riscos, controle das emoções e de sentimentos. O objetivo deste estudo objetivo conhecer a construção social e cultura de ser homem gaúcho na perspectiva de Pierre Bourdieu. Trata-se de um estudo de abordagem qualitativa e interpretativa, por meio dos conceitos de dominação masculina de Pierre Bourdieu realizado com nove homens em tratamento por câncer de próstata. A coleta de dados correu por meio de uma entrevista semiestruturada e para análise de dados utilizou-se a análise temática. O projeto obteve aprovação do Comitê de Ética em Pesquisa, sob parecer nº 2.608.801. De acordo com os resultados, o significado de ser homem revelou a construção social e a superioridade masculina diante do feminino. O ser homem foi relacionado ao sustento da casa e a força física. Tal visão de superioridade costuma ser uma construção social e cultural perpassada por gerações. Nessa perspectiva, tais demonstrações de superioridade, de coragem e nobreza seriam socialmente esperadas do verdadeiramente homem. Neste contexto conclui-se que as concepções sociais de dominação masculina influenciam a forma como os homens vivem, tendo em vista que sua constituição de identidade psicossocial marcada por valores, comportamentos e atitudes socioculturalmente construídos.
Associação entre problemas de voz e efeitos do ruído na saúde de operadores de um Call Center da cidade de Campinas-SP
Authors: Silva Rosy Neves da , Passos Priscila Silva , Fiorini Ana Claudia
Published: March 2022

Objetivo. Investigar as possíveis associações entre as queixas de voz e os efeitos do ruído na saúde de funcionários de um Call Center na cidade de Canpinas-SP. Metodologia. Estudo observacional e transversal de inquérito, realizado em 212 operadores de teleatendimento de uma empresa na cidade de Campinas-SP. Os procedimentos incluíram a aplicação de dois instrumentos: questionário sobre incômodo ocasionado por ruído e os demais efeitos e Índice de Triagem de Distúrbio de Voz (ITDV). A análise estatística utilizou como desfecho principal a presença de queixa de voz. As associações entre o desfecho principal e as demais variáveis foram realizadas por meio da aplicação de testes qui-quadrado e de um modelo de regressão logística múltipla. Resultados. A amostra foi constituída principalmente por mulheres (87,3%) e a média de idade foi 24,8 anos. Os resultados identificaram altas ocorrências de queixas vocais (45,3%) e dos demais efeitos relacionados à exposição ao ruído no local de trabalho como incômodo, estresse, dificuldade de comunicação, falta de atenção e dores de cabeça. Conclusão. As condições ambientais e organizacionais e os efeitos à saúde não somente foram associados significativamente, mas, também, aumentam a chance de um operador de teleatendimento apresentar queixas de voz.
Óleo de Castanha-do-Brasil: métodos de extração e aplicações na indústria
Authors: Carvalho Arthur Lobato Silva , Martelli Marlice Cruz , Nascimento Shirley Cristina Cabral , Brasil Davi do Socorro Barros
Published: March 2022

A Amazônia é uma região rica em biodiversidade de fauna e flora onde existem diversas espécies vegetais que possuem potencial de produção de fármacos, cosméticos, combustíveis e alimentos de forma geral. Dessa forma, a castanha-do-Brasil (Bertholletia excelsa H.B.K) é estabelecida como fonte alimentícia de povos oriundos desta região. Além disso, o óleo vegetal de castanha-do-Brasil, extraído por várias técnicas, é estudado com base em seu potencial lipídico e antioxidante. O presente trabalho objetivou comparar os métodos de extração empregados no óleo de castanha-do-Brasil com base em dados publicados na literatura considerando análises físico-químicas comumente realizadas para avaliar esse produto, além de uma revisão de fatores característicos de matérias-primas de grande utilidade em âmbito industrial na área alimentícia, de cosméticos e de biocombustíveis, de modo a agregar no desenvolvimento de possíveis aplicações para o óleo de castanha-do-Brasil. Sendo assim, os métodos tradicionais de extração (por prensagem a frio e por solvente) ainda são os mais utilizados na indústria em virtude de apresentarem melhor rendimento e características físico-químicas estáveis, enquanto metodologias alternativas, tais como, o uso de solvente verdes, solventes em condições supercríticas e ultrassom possuem limitações que impedem a viabilização de seus usos em ampla escala.
Estudo da Mortalidade Proporcional e transições do processo de saúde no estado de Alagoas
Authors: Santos Milena Alicia da Silva , Almeida Vitória Braz de , Passos Neta Maria Delma Carnaúba , Dias Maria de Lourdes Domingos da Silva , Almeida Alda Graciele Claudio dos Santos , Bádue Gabriel Soares
Published: March 2022

Introdução: Considera-se como mortalidade proporcional a medida da importância de uma causa de morte específica em relação a todas as causas de morte em um mesmo grupo populacional, podendo relacionar ao sexo, faixa etária, entre outros. Nesse sentido, estudos a partir dos dados epidemiológicos permitem investigar aspectos envolvidos acerca das possíveis causas que têm ocasionado o crescente aumento nos óbitos. Objetivo: Analisar os dados epidemiológicos da mortalidade proporcional e as transições que ocorreram no processo de saúde no estado de Alagoas durante o intervalo de 2010 a 2019. Metodologia: Estudo descritivo, realizado com base nos dados registrados sobre mortalidade proporcional no Estado de Alagoas. Todos os registros foram obtidos através da plataforma DataSus e coletados em agosto de 2021. Resultados: Analisou-se aumento na mortalidade dos indivíduos com faixa etária acima dos 40 anos, relacionada às doenças do aparelho circulatório. Elevado número de óbitos por causas externas do sexo masculino na faixa etária dos 20-29 anos. Óbitos em menores de 1 ano relacionam-se a afecções originadas no período perinatal, como a prematuridade e fatores ligados ao parto e ao pós parto. Em indivíduos do sexo masculino, destaca-se maior taxa de mortalidade. Conclusão: Analisando as causas de óbitos durante os 10 anos, há prevalência para doenças do aparelho circulatório com progressão durante os anos, enquanto que por causas externas de morbidade e mortalidade sofreram variações, obtendo-se regressão nos últimos anos. Observa-se também uma elevação gradativa da mortalidade por neoplasias no decorrer da década estudada. Sendo prevalente, mortalidade por sexo masculino.
Vegetative and reproductive phenology of Copaifera langsdorffii Desf. in different phytophysiognomies
Authors: Santos Maria de Oliveira , Almeida Bianca Vilar de , Campos Natália Barbosa , Macedo Julimery Gonçalves Ferreira , Macêdo Márcia Jordana Ferreira , Ribeiro Daiany Alves , Silva Maria Arlene Pessoa da , Calixto Júnior João Tavares , Costa José Galberto Martins da , Souza Marta Maria de Almeida
Published: March 2022

The phenology has been discussed according to climatic variations and the environmental characteristics of each physiognomy, trying to identify if there is variation in the vegetative and reproductive phenophases, for Copaifera langsdorffii Desf. in areas of the Cerradão, Carrasco and Humid Forest, Chapada do Araripe in Northeast Brazil and if they are correlated with seasonality. Monthly observation censuses were conducted on 10 individuals from each area from January 2019 to December 2020. The continuous, sub-annual, annual, and supra-annual classes were taken into account. The intensity and synchrony of individuals were evaluated, and seasonality was tested using Spearman's correlation with local weather variables. The species presented a semi-deciduous vegetative phenological strategy, with peaks occurring mainly at the end of the rainy season and the beginning of the dry season. The flowering pattern of C. langsdorffii was considered annual and seasonal, because flowering occurred at similar periods in the three areas, with peaks in December and January. Fructification occurred annually, with seasonality only in the phyto-physiognomy of the Cerradão. C. langsdorffii bore fruit during the rainy season in the Cerradão, Carrasco and Humid Forest, with the exception only of 2020 in the Carrasco and Humid Forest, where individuals bore fruit during both the rainy and dry seasons. According to the correlation results, precipitation, temperature, and humidity shape the reproductive patterns of C. langsdorffii, which may also occur in populations of this species in other environments.
Potencial agronômico e valor nutritivo de forrageiras implantadas na integração com a cultura do milho
Authors: Rezende Adauton Vilela de , Prado Raphaela Aparecida Tomaz do , Faustino Thailson Fernando , Florentino Ligiane Aparecida , Silva Nhayandra Christina Dias e , Santos Patrícia Cristina de Oliveira dos
Published: March 2022

Objetivou-se com esta pesquisa, avaliar o potencial agronômico e o valor nutricional de forrageiras implantadas em   consórcio com a cultura do milho. Os tratamentos foram distribuídos em blocos casualizados em esquema fatorial 4 x 3 (4 gramíneas - Urochloa brizantha cv. Marandu, Urochloa brizantha cv. MG4, Urochloa brizantha cv. MG5 e Panicum maximum cv. Mombaça - 3 métodos de semeadura - plantio da forrageira junto a semeadura do milho, plantio da forrageira no momento da cobertura do milho, cobertura e plantio das gramíneas isoladamente), totalizando 12 tratamentos com 4 repetições. Foram analisadas as seguintes variáveis: número de perfilho, teor de matéria seca total (MST), matéria seca de folha (MSF), matéria seca de colmo (MSC), produtividade de matéria seca/ha, percentual de folhas, percentual de colmo, fibra em detergente neutro (FDN), fibra em detergente ácido (FDA), proteína bruta (PB) e digestibilidade in vitro da matéria seca (DIVMS). O método de plantio das forrageiras semeadas sem consórcio apresentou maiores números de perfilhos, percentual de folhas, maior produtividade, além de aumentar a digestibilidade in vitro da MS e reduzir o percentual de colmos. Diante dos resultados obtidos nesta pesquisa, observou-se que a implantação de forrageiras em consórcio com o milho, interferiu negativamente no estabelecimento de forrageiras consorciadas na produtividade de grãos e na qualidade bromatológicas das forrageiras.