bluuebunny/crossref_metadata_2025 huggingface dataset:
Differences of Fibronectin Levels in First Trimester Normal Pregnency and Miscarriage
Authors: Fadhilah Maisarah , Utama Bobby Indra , Tofrizal Tofrizal
Published: October 2024

Introduction: Miscarriage is a reflection of the low quality of health in pregnant women. The incidence of miscarriage in the world accounts for 23 million (15%) of the 130 million births per year and up to 80% of miscarriages occur in the first trimester of pregnancy. Miscarriage will affect a woman's social, physical, and psychological. The complexity of the negative impact of miscarriage makes it necessary to pay special attention. Biomarker examination is needed to more accurately identify pregnancies at risk of miscarriage before the appearance of clinical symptoms. The use of fetal fibronectin (fFN) levels have been used as a marker of unexpected labor and as evidence of premature rupture of the fetal membranes. Normally fFN can be detected in cervical and vaginal secretions at <20 weeks gestation. The presence of fFN at >22 weeks gestation indicates disruption of the uteroplacental surface. Therefore, if screening for fibronectin levels using the Enzyme-Linked Immunosorbent Assay (ELISA) test can be carried out in the first trimester of pregnancy, there is a high possibility that miscarriage can be prevented.Method: The type of research is analytical observational research with a cross-sectional research design. The stored samples were examined for fibronectin levels using the ELISA test, which included 21 blood serum samples from normal pregnancy patients in the first trimester and 21 miscarriage samples.Results: The results of the ELISA test produced an average first-trimester normal pregnancy fibronectin level of 118.8 Â± 18.4 ng/mL while the miscarriage fibronectin level was 208.2 Â± 152.0 ng/mL. Data analysis using the Mann-Whitney test obtained a p-value = 0.138, which means there was no significant difference in fibronectin levels between normal pregnancy in the first trimester and miscarriage.Conclusion: This study concludes that fibronectin levels are not specific biomarkers in detecting miscarriage in the first trimester of pregnancy.
Peritional Tuberculosis in Young Age Lady Miicking Gynecology Malignancy: a Case Report
Authors: Sari Lusi Jelita , Antonius Puja Agung , Muhammad Syamel
Published: October 2024

Background : Peritoneal tuberculosis is one of the most challenging forms of extrapulmonary tuberculosis to diagnose. Extrapulmonary TB is very difficult to diagnose because of its non-specific signs and symptoms, thus it sometimes leads to a diagnosis of gynaecological malignancy such as advanced ovarian carcinoma.
Case Report : A teenage girl, 12 years old, with a chief complaint of intermittent abdominal pain since the last 1 month. There was no history of an enlarged abdomen, fever and weight loss. Ultrasound examination revealed an irregular adnexal mass suggesting an ovarian malignancy with other possibilities of an infectious process. Diagnostic laparoscopy and peritoneal biopsy were performed on the patient. Intraoperatively, multiple friable nodular-mylar peritoneal masses with abdominopelvic attachments and fibrin fibres and white vesicles were found on the entire surface of the genitalia, peritoneum, and intestines. A mass biopsy was performed with histopathological results showing peritoneal tuberculosis. Currently, the patient is undergoing anti-tuberculosis drugs (OAT) treatment.
Discussion : The diagnosis of this disease is difficult to establish. Symptoms are highly variable and non-specific and can lead to the wrong tumour pathology. The clinical characteristics are dominated by changes in general condition, abdominal pain and transit disorders, as well as masses (20 to 25%). The gold standard for definitive PTB diagnosis remains laparoscopy with peritoneal biopsy and subsequent pathological or microbiological confirmation. Yellow/white nodules in the peritoneum observed on the patient's laparoscopic images are the hallmark of wet peritoneal TB. Omental thickening and abdominal cocoon with matted small bowel are other classic laparoscopic findings for peritoneal TB.
Conclusion: PTB has similar characteristics to peritoneal carcinoma, which makes diagnosis difficult for clinicians. Early and correct diagnosis of PT
Factors Associated With Physical Therapy Attendance Rate and Self-Discharge in People With Chronic Pain
Authors: Balinski Mariah , Blanchard Leanna , Mendoza Renzo , Zaranec Morgan , Duncombe Alison , Madhavan Sangeetha
Published: October 2024

OBJECTIVE: To identify factors associated with physical therapy (PT) attendance and self-discharge in patients with chronic pain.

DESIGN: Retrospective chart review with survey.

METHODS: Organizational reports were screened for patients with chronic pain. A retrospective review of the electronic medical record was performed, and a survey invitation was sent to the evaluating therapist. Poisson regression analyzed factors related to attendance, while logistic regression analyzed factors related to self-discharge.

RESULTS: The 200 patients had attendance and self-discharge rates of 73% and 55%, respectively. Attendance rates were lower in patients whose therapists reported higher comfort levels with treating chronic pain and slightly higher in patients with a longer duration of care. Odds of self-discharge were higher if the patient had a higher no-show rate or was seen by a therapist reporting higher comfort levels with treating chronic pain but were lower if more PT visits were completed.

CONCLUSION: In this study, attendance rates and self-discharge were related to several patient- and therapist-driven factors. Therapists should identify each patient’s potential facilitators and/or barriers to attending PT and prepare them for self-management of their condition upon discharge. JOSPT Open 2024;2(4):332-339. Epub 7 August 2024. doi:10.2519/josptopen.2024.1136
The Role of HIPEC in Colon Cancer: Retrospective Analysis of 15 Cases
Authors: Gowda Naveen , S Raxith , M Vijay Kumar
Published: October 2024

Objectives:

To evaluate the outcomes of hyperthermic intraperitoneal chemotherapy (HIPEC) combined with cytoreductive surgery in patients with peritoneal carcinomatosis secondary to colon cancer treated at Bharath Cancer Hospital over one year.

Material and Methods:

From August 2022 to August 2023, 15 patients with colon cancer and confirmed peritoneal metastasis underwent cytoreductive surgery followed by HIPEC using Mitomycin C and Oxaliplatin. Inclusion criteria consisted of peritoneal metastasis without extraperitoneal disease, good performance status, and the feasibility of achieving complete cytoreduction (CC-0 or CC-1). The Peritoneal Cancer Index (PCI) was used to assess disease burden.

Results:

The average patient age was 56 years, with PCI scores ranging from 8 to 20. Complete cytoreduction (CC-0) was achieved in 73.3% of patients. The average operative time was 8 hours. Postoperative complications occurred in 33.3% of patients, with no perioperative or 30-day mortality. Peritoneal recurrence occurred in 20% of cases.

Conclusion:

HIPEC, when combined with cytoreductive surgery, demonstrates promising short-term outcomes in selected patients with peritoneal carcinomatosis from colon cancer. Although the recurrence rate was relatively low, further research is necessary to confirm long-term benefits and refine patient selection criteria.
Co-WIN and Ayushman Bharat Digital Mission: The way forward
Authors: ATHAVLE PULKIT
Published: October 2024

As Covid-19 becomes, for better or worse, an endemic disease, the future of the revolutionary Covid-19 Vaccine Intelligence Network (Co-WIN) platform needs to be considered seriously. Rather than being made obsolete, the Co-WIN platform can serve as a stepping stone to catalyse a true digital healthcare revolution in India if steps are taken to harness its features and data for varied uses as part of the Ayushman Bharat Digital Mission. By bringing these features to other vaccinations, as well as integrating outbreak data from the Integrated Health Information Platform for public knowledge and awareness, disease responses can become faster and more public-driven (rather than government-driven as currently). This will also create a data pool that will be of value in post-vaccination monitoring.
A Hybrid Meta On-Top Functional for Multiconfiguration Pair-Density Functional Theory
Authors: Bao Jie J. , Zhang Dayou , Zhang Shaoting , Gagliardi Laura , Truhlar Donald
Published: October 2024

Multiconfiguration pair-density functional theory (MC-PDFT) was proposed a decade ago, but it is still in the early stage of density functional development. MC-PDFT uses functionals that are called on-top functionals; they depend on the density and the on-top pair density. Most MCPDFT calculations to date have been unoptimized translations of generalized gradient approximations (GGAs) of Kohn–Sham density functional theory (KS-DFT). A hybrid MCPDFT has also been developed, in which one includes a fraction of the CASSCF wave function energy in the total energy. Meta-GGA functionals, which use kinetic-energy densities in addition to GGA ingredients, have shown higher accuracy than GGAs in KS-DFT, yet the translation of meta-GGA has not been previously proposed for MC-PDFT. In this paper, we propose a way to include kinetic energy density in a hybrid on-top functional for MC-PDFT, and we optimize the parameters of the resulting functional by training with a new database containing a wide variety of systems with diverse characters. The resulting hybrid meta functional is called the MC23 functional. We find that MC23 has equally improved performance as compared to KS-DFT functionals for both strongly and weakly correlated systems. We recommend MC23 for future MC-PDFT calculations.
Tautomerization Between Vinyl Alcohol and Acetaldehyde During Catalytic Ethanol Oxidation: The Effect of Water Molecules
Authors: Wu Ruitao , Ore Rotimi , Wang Lichang
Published: October 2024

Catalytic ethanol oxidation reaction (EOR) takes place via many elementary reactions, such as dehydrogenation, C-C bond cleavage, and oxidation of C1 species. Recent studies indicate that hydrogen transfer reaction between intermediate species may need to be included in the reaction network to fully understand the transient kinetics of EOR catalysis. Furthermore, it is important to examine the requirement of the minimum elementary reactions (MERs) in the complex EOR network to calculate the apparent reaction rate and product selectivity. In this work, we performed density functional theory calculations to study the effects of catalyst using Ir(100) and one or two water molecules on the tautomerization reaction between vinyl alcohol (VA) and acetaldehyde (AA). The DFT results show that Ir(100) does not lower the VA-AA tautomerization barrier significantly, however, the presence of water molecules lowers the VA-AA tautomerization barrier considerably. This illustrates that VV-AA tautomerization during EOR occurs with water molecules serving as catalysts.
Fewer, but better: on the benefits of surfactant-free colloidal syntheses of nanomaterials
Authors: Varga Marton , Quinson Jonathan
Published: October 2024

Colloidal syntheses are common bottom-up synthetic approaches to obtain various nanomaterials, e.g. gold nanoparticles, where a precursor, e.g. HAuCl4, is reduced in presence of reducing agents in a solvent. It is often claimed, and almost dogmatically believed, that stabilizers, capping agents, ligands, surfactants or other additives, must be added to ensure the stability of the colloids. Although there is almost a systematic use of such chemicals in the literature, a range of surfactant-free, or additive-free, colloidal syntheses have been reported. In those syntheses, the solvent plays the role of source of reducing agents and/or stabilizers. Recently, the use of alkaline solutions of low viscosity mono-alcohols, such as ethanol, has been shown to lead to stable surfactant-free colloids for various metal nanoparticles. Here, with the example of gold nanoparticles obtained at room temperature, it is shown that adding commonly reported stabilizers, such as trisodium citrate, PVP, SDS, poly(NIPAM), CTAB, or chemicals such as hydroquinone, actually does not lead to any advantages compared to the surfactant-free colloidal synthesis performed in alkaline mixture of water and 20 v.% ethanol. The results stress the potential of surfactant-free approaches compared to more conventional surfactant- and additives- assisted strategies to develop greener research studies and syntheses.
Efficient generation of open multi-stage fragmentation mass spectral libraries
Authors: Brungs Corinna , Schmid Robin , Heuckeroth Steffen , Mazumdar Aninda , Drexler Matúš , Šácha Pavel , Dorrestein Pieter C. , Petras Daniel , Nothias Louis-Felix , Veverka Václav , Nencka Radim , Kameník Zdeněk , Pluskal Tomáš
Published: October 2024

Untargeted analysis based on high-resolution mass spectrometry is a key tool in clinical metabolomics, natural product discovery, and exposomics, with compound identification remaining the major bottleneck. Currently, MS2 fragmentation data and spectral library matching are the standard workflow for confident compound annotation. Multi-stage fragmentation (MSn) yields more profound insights into substructures, enabling validation of fragmentation pathways; however, the community lacks open MSn data for reference compounds. Here, we describe a high-throughput method for acquiring MSn trees and an automated workflow for extracting and building open MSn libraries. By applying this pipeline to 37,829 small molecules, we obtained MSn spectra for 30,008 unique compound structures within 23 days. This resource includes 2,350,646 MSn spectra (merged and individual) and can be leveraged for compound annotation based on library matching, including substructures and training of machine learning models on substructure-fragmentation patterns. The workflow, implemented in mzmine and Python scripts, is open-source and freely available.
Widespread misinterpretation of pKa terminology for zwitterionic compounds and its consequences
Authors: Zheng Jonathan , Leito Ivo , Green William
Published: October 2024

The acid dissociation constant (pK a), which quantifies the propensity for a solute to donate a proton to its solvent, is crucial for drug design and synthesis, environmental fate studies, chemical manufacturing, and many other fields. Unfortunately, the terminology used for describing acid base phenomena is inconsistent, causing large potential for misinterpretation. In this work, we examine a systematic confusion underlying the definition of “acidic” and “basic” pKa values for zwitterionic compounds. Due to this confusion, some pKa data is misrepresented in data repositories, including the widely- used and highly trusted ChEMBL Database. Such datasets are widely used to supply training data for pKa prediction models, and hence, confusion and errors in the data makes model performance worse. Herein, we discuss the intricacies of this issue. We make suggestions for describing acid-base phenomena, training pKa prediction models, and stewarding pKa datasets, given the high potential for confusion and potentially high impact of accurately describing acid-base phenomena.
Novel Supramolecular Artificial Light-Harvesting Systems Based on AIE-active Macrocycle for Efficient White-Light Photocatalysis in Water.
Authors: ke chen , juncheng Yang , guo ling zhang , chunxuan qi , hai tao Feng , ben zhong Tang
Published: October 2024

Constructing supramolecular artificial light-harvesting systems (ALHSs) based on the Förster resonance energy transfer (FRET) mechanism provides an optimal platform for understanding the natural photosynthesis and simulating the natural light-harvesting systems. In the present work, rigid macrocycle K-1 with nonplanar conformation and aggregation-induced emission (AIE) property was selected as an energy donor in ALHS, while the non-cyclic AIEgen K-2 was used for comparative study. In aqueous solution, an efficient one-step energy-transfer process was readily established between blue-emitting K-1 and an acceptor (namely PBTB) with orange fluorescence to afford a high energy-transfer efficiency (ΦET) of up to 82.6% at the optimal donor/acceptor (K-1/PBTB) ratio of 1000:40, while the K-2/PBTB assemblies gave a ΦET of 77.9% under the same conditions. Notably, bright white light emission can be successfully realized with a CIE coordinate of (0.33, 0.34) at the ratio of K-1/PBTB = 200:1 and the ratio of K-2/PBTB = 500:3, respectively. Moreover, the triad FRET system was fabricated through energy transfer from the AIEgens to PBTB, then further transferring the captured energy to the final red-emitting receptor (namely as Z1), achieving an efficient two-step sequential energy transfer. When the ratio of K-1/PBTB/Z1 assemblies reached 1000:40:14, the optimal ΦET was 66.4%, which is higher than that of K-2/PBTB/Z1 assemblies under the same ratio. More importantly, it was found that the ALHS based on macrocycle K-1 showed much higher photocatalytic activity for the cross-dehydrogenative coupling (CDC) reaction with an 87% yield under white-light illumination in water than that of the non-cyclic AIEgen K-2 (35% yield). Therefore, the flexibility of this novel supramolecular strategy renders the macrocyclic AIEgen a promising candidate to construct efficient ALHSs for photocatalysis.
О моноиде с разрешимой теорией конечных подмножеств
Authors: Дудаков Сергей Михайлович
Published: October 2024

В наших предыдущих работах мы продемонстрировали, что теория конечных подмножеств различных ассоциативных алгебр позволяет интерпретировать элементарную арифметику, в частности, она неразрешима. Например, это было показано для любых бесконечных абелевых групп. Возникает естественный вопрос: можно ли обобщить этот результат на более широкий класс алгебр, скажем, все коммутативные моноиды. В некоторых случаях нами ответ тоже получен ранее: для коммутативных моноидов с сокращением, имеющим элемент бесконечного порядка или произвольных абелевых групп. Сейчас же мы продемонстрируем, что не для всяких коммутативных моноидов это верно. Более того, мы дадим описание конструкции, которая позволяет строить такого рода системы из разного рода исходных алгебр. Вместе с тем, будут указаны и некоторые границы её применимости.

In our previous works, we have proved for various associative algebras that the finite subsets theory allows to interpret elementary arithmetic, in particular, such theory is undecidable. For example, this is proved for all infinite Abelian groups. A natural question arises: can we generalize this result to a wider class of algebras, for example, all commutative monoids. In some cases, we also have proved analogous result: for commutative cancellative monoids with an element of infinite order, or arbitrary Abelian groups. In this paper we prove that this is not true for arbitrary commutative monoids. Moreover, we propose a method that allows to construct such algebras by various original algebras. Also, we have found a limitation of this method.
Desarrollo de plataforma de bajo costo para el monitoreo de condiciones microclimáticas favorables al surgimiento del hongo Botrytis Cinerea en el cultivo de mora de Castilla departamento Risaralda
Authors: Rodas Alejandro , Chavarro Porras Julio César , Guerrero Álvarez Gloria Edith
Published: October 2024

La mora de Castilla (Rubus glaucus Benth) se caracteriza por crecer en climas fríos y moderados en países de la región andina y es considerado un cultivo importante en diferentes zonas de Colombia. La mora de Castilla es afectada por el hongo Botrytis cinerea, este es favorecido por factores ambientales como bajas temperaturas, alta humedad relativa, altas precipitaciones, humedad de la hoja y condiciones de luz (espectro UV) las cuales influyen en cada una de etapas de desarrollo de la planta bajo una amplia gama de condiciones de microclimáticas. Por tanto, es primordial realizar estudios en relación con el microclima existente en un cultivo mediante la instalación de varias estaciones climáticas dado que dichas condiciones climatológicas varían entre cultivo y cultivo. En este escenario, Agricultura de Precisión y el Internet de las Cosas (Iot) se presentan como una solución. No obstante, un desafío crítico del sector agrícola es el alto costo de la adopción de estas tecnologías. Dispositivos como dataloggers o estaciones meteorológicas pueden oscilar entre los 6 COP millones en adelante, corriendo el riesgo de un retorno de la inversión insuficiente. Aunque en el contexto internacional la adopción de tecnologías digitales de bajo costo (sensores, plataformas, sistema embebidos) ha tomado fuerza, la integración de estas en el análisis de microclimas que puedan favorecer la presencia de Botrytis cinerea en el cultivo de mora de Castilla, no se encontraron investigaciones relacionadas. Por tanto, en la presente investigación se plantea la construcción una plataforma de bajo costo (software/hardware) que registre las condiciones microclimáticas que favorecen el brote de Botrytis cinerea en el cultivo de Mora de Castilla en el departamento de Risaralda así como el uso de técnicas de aprendizaje de automático para identificar patrones o relaciones entre las variables registradas.
Mapeo del rendimiento de cosecha mediante sistema de detección y conteo de fresas
Authors: Pardo Camilo , Parra Carlos , Solaque Leonardo
Published: October 2024

Se ha desarrollado un sistema de visión artificial para mejorar el monitoreo y rendimiento del cultivo de fresas en Colombia, un sector crucial para el desarrollo sostenible del país. Este sistema innovador emplea algoritmos de visión artificial para realizar una adquisición de información no invasiva, facilitando el análisis detallado de las condiciones del cultivo. El proceso de desarrollo consta de tres etapas principales: adquisición y preprocesamiento de datos, detección y seguimiento de frutos, y segmentación y clasificación para estimar el rendimiento de la cosecha. En la primera etapa, el sistema utiliza una cámara 3D Intel RealSense D435i junto con un sistema GPS RTK para capturar imágenes georreferenciadas de los surcos de cultivo. Las imágenes preprocesadas son transferidas a la segunda etapa, donde algoritmos de Deep Learning, como Mask-RCNN y YoloV8, detectan y cuentan los frutos en las imágenes. La tercera etapa mejora la segmentación y extracción de características de los frutos, alimentando un sistema de clasificación que genera estimaciones precisas del rendimiento de la cosecha. Este sistema integral combina técnicas de Visión Artificial y procesamiento de datos georreferenciados, ofreciendo una herramienta eficaz para la gestión del cultivo de fresas.
Estrategias para aumentar el número de aspirantes a las carreras de ingeniería: revisión y recomendaciones reportadas en la literatura
Authors: Botero Castro Héctor Antonio , Botero Pérez Julián , Saavedra Montes Andrés Julián
Published: October 2024

La disminución del número de aspirantes en ciertas carreras de ingeniería es una tendencia que ha impactado varios programas en Colombia, incluyendo IE, Ingeniería Electrónica e Ingeniería de Control. Este fenómeno no es exclusivo de Colombia, ya que se ha observado en otros países, lo que ha llevado a la implementación de diversas estrategias para incentivar a los estudiantes de último año de la educación media a elegir estas carreras. Tales estrategias van desde la realización de estudios y encuestas para comprender la motivación de los estudiantes, hasta la ejecución de proyectos colaborativos entre colegios y universidades. Este artículo presenta una revisión sobre este tema, acompañada de recomendaciones para abordar el problema en el contexto colombiano.
Enfriando el futuro: una experiencia didáctica interdisciplinaria de educación energética para fomentar un uso racional de los aires acondicionados en espacios universitarios
Authors: Ramírez José , Morrillo Torres Daniel
Published: October 2024

El calentamiento global, el crecimiento poblacional y la demanda de las economías emergentes han aumentado significativamente la instalación de equipos de aire acondicionado, y se estima que para 2050, este sector demandará tanta electricidad como China e India juntas. Esto resalta la necesidad de mejorar la sostenibilidad del sector tanto tecnológica como en la gestión, promoviendo mejores hábitos de consumo energético y conciencia ambiental. Este trabajo se enfoca en el aspecto de gestión y educación energética, especialmente en el contexto universitario, donde hasta el 70% del consumo energético se debe al uso de aires acondicionados. La experiencia propuesta se centró en la Universidad Javeriana Cali, buscando caracterizar las causas del consumo energético para identificar potenciales de ahorro, mediante estrategias de gestión de recursos y educación ambiental. Se diseñó la experiencia "Enfriando el Futuro" para fomentar el desarrollo de habilidades blandas y pensamiento crítico en los estudiantes para abordar la problemática energética de manera creativa y colaborativa. Utilizando la metodología de Design Thinking, la experiencia se estructuró en tres fases: 1) Conciencia Energética, que diagnosticó el nivel de conciencia y conocimientos sobre el consumo de energía; 2) Inmersión Energética, que identificó perfiles de usuarios para empatizar y comprender sus necesidades; e 3) Innovación Sostenible, que buscó soluciones innovadoras utilizando herramientas de pensamiento crítico. Llevada a cabo del 22 al 24 de septiembre de 2023, la experiencia convocó a 100 estudiantes para generar soluciones innovadoras sobre el uso racional de la energía en aire acondicionado en la universidad. Los resultados incluyeron la adquisición de conocimientos y conciencia energética por parte de los estudiantes, y la identificación de soluciones innovadoras para el uso racional de la energía en aires acondicionados. La experiencia también brindó una nueva perspectiva sobre el problema y su impacto en la cultura estudiantil. Se espera que la universidad evalúe e implemente las soluciones propuestas por los estudiantes. Este proyecto subraya la importancia de abordar la problemática energética no desde una perspectiva tecnológica, sino a través de una mayor conciencia ambiental y social, promoviendo una cultura de uso racional de los recursos energéticos para un futuro más sostenible.
Transición hacia la modalidad combinada de aprendizaje post-pandemia: un análisis en dos universidades colombianas
Authors: Pérez Montero Eilen , Hernández Henríquez María Mercedes
Published: October 2024

Las tecnologías de la información y comunicación (TIC) han avanzado vertiginosamente en la transformación educativa, lo que se hizo evidente en tiempos del confinamiento a causa del SARS Covid-19. Este estudio analiza las percepciones de 120 estudiantes universitarios con las modalidades de enseñanza-aprendizaje después de la pandemia, el impacto a retomar a la presencialidad y la aceptación de las herramientas tecnológicas en la vida académica; así como su articulación a los Objetivos Desarrollo Sostenible (ODS). Para ello, se aplicó un cuestionario con 28 preguntas cerradas de 2 Universidades del departamento de Huila (Colombia) bajo la modalidad presencial, una de carácter público y otra privada, empleando un enfoque transversal exploratorio-descriptivo. Para obtener las distribuciones de frecuencia se empleó el programa IBM SPSS Statistics (versión 26), pruebas de normalidad, tablas cruzadas con apoyo en la prueba Kolmogorov-Smirnov para verificar la distribución de los datos. Los resultados evidenciaron el desarrollo de un modelo de educación presencial con el web denominado b learning, empleado en el diseño, impartición de la instrucción, asesoramiento y evaluación, permitiendo la flexibilidad y enriqueciendo la experiencia de aprendizaje. Esta tendencia ofrece una oportunidad clave para avanzar en el logro del cuarto Objetivo de Desarrollo Sostenible, que se centra en garantizar una educación inclusiva, equitativa y de calidad, y promover oportunidades de aprendizaje durante toda la vida para todos. Al facilitar la conectividad y el acceso al conocimiento, esta modalidad promueve el desarrollo de competencias digitales esenciales en el mundo moderno. Además, fomenta nuevas metodologías de enseñanza-aprendizaje que se adaptan a las necesidades y expectativas de los estudiantes del siglo XXI.
Discusiones en torno a la industria láctea en un contexto internacional: una revisión sistemática de literatura y agenda de investigación
Authors: Macias Urrego Jackeline Andrea , Montoya Restrepo Luz Alexandra , Garcia Pineda Vanessa
Published: October 2024

La nueva agricultura se caracteriza por la emergencia de mercados dinámicos, avances tecnológicos e institucionales significativos, el enfoque en el desarrollo sostenible, y los desafíos y roles asignados al Estado, al sector privado y a la sociedad civil. Dentro de este panorama, el sector agropecuario desempeña un papel crucial en la producción de alimentos y materias primas, destinados tanto a los mercados domésticos como internacionales. Destacando dentro de este sector, la industria láctea emerge como un actor de gran relevancia en la agroindustria. Por ende, este estudio tiene como finalidad realizar una exploración preliminar sobre las discusiones en torno a la industria láctea en un contexto internacional. Para ello, se ha optado por una metodología de revisión sistemática de la literatura utilizando la base de datos SCOPUS y su análisis bibliométrico, donde se procesó y analizó un total de 64 documentos. Entre los hallazgos más notables, se propone una agenda de investigación basada en los resultados obtenidos, identificando brechas en áreas de conocimiento tales como la administración, creación de valor, institucionalidad, transformación tecnológica y la aplicación de tecnologías en la industria. Esto permitirá ofrecer a la comunidad académica y científica propuestas concretas que contribuyan al desarrollo de la industria láctea, sus procesos productivos y su cadena de valor.
Lübnan’ın Güney Sınırı: Çatışma, İşgal ve Toprak İhtilafı
Authors: Atlıoğlu Yasin
Published: October 2024

7 Ekim 2023'te Hamas'ın Gazze Şeridi'nden İsrail'e saldırmasının ardından Hizbullah ile İsrail arasında Lübnan'ın güney sınırı boyunca kaygı verici ve tehlikeli bir askeri gerginlik ortaya çıktı. Sınırda aylardır karşılıklı olarak düzenlenen saldırılar, Lübnan’ın güneyinde aralarında sivillerin de bulunduğu yüzlerce can kaybına, büyük bir maddi yıkıma ve kitlesel göçe yol açtı. Aynı zamanda çatışmanın Lübnan topraklarına taşınarak geniş çaplı bir savaşa dönüşmesi ihtimalini ortaya çıkardı. Lübnan'ın güney sınırındaki çatışma, her ne kadar Hizbullah ile İsrail arasında bir silahlı mücadele olarak görülse de aslında 1920'lere kadar giden tarihsel bir sürecin ürünüdür. Lübnan’ın güneydeki sınır hattı, ilk kez 1923’te İngilizler ve Fransızlar tarafından Lübnan-Filistin sınırı olarak çizildi, fakat 1949’da yapılan ateşkes antlaşmasıyla de facto bir Lübnan-İsrail sınırına dönüştü. Bu sınır hattı, 1967 Arap-İsrail Savaşı’ndan günümüze, silahlı çatışmaları, işgalleri ve toprak ihtilaflarını içeren bir çatışma için uygun bir zemin oluşturdu. Bu çalışmada, Lübnan’ın güney sınırının yüzyıllık tarihi boyunca yaşanan siyasi ve askeri mücadeleler, işgaller, toprak ihtilafları, sınırın hukuki statüsündeki değişiklikler ve tarafların sınır konusundaki iddiaları incelenmektedir. Bu bağlamda Lübnan’ın güney sınırında çatışmaya yol açan temel faktörlerin tespit edilmesi amaçlanmaktadır.
ANTECEDENTES NA INTENÇÃO DE RECOMPRA EM DUAS ACADEMIAS COM MODELOS DIFERENTES NA CIDADE DE SAPIRANGA-RS
Authors: Curth Marcelo , Berle Ariel Natan , Kerber Luis Eurico , Bettiato Julia Vogel
Published: October 2024

Objetivo: O objetivo deste estudo foi identificar a influência da confiança e percepção de valor no boca a boca de clientes de duas academias com modelos de negócios distintos na cidade de Sapiranga - RS.
Referencial Teórico: Este trabalho tem como tema a influência do boca a boca, e a finalidade de apresentar características que possam facilitar o melhor entendimento sobre alguns de seus antecedentes (confiança e percepção de valor).
Método: Foi realizada uma survey com 188 respondentes. A técnica estatística utilizada foi Modelagem de Equações Estruturais (MEE) por meio da qual foi testado o modelo conceitual.
Resultados e Discussão: Os resultados mostram as principais variáveis de valor percebido e dimensões que influenciam positivamente a intenção de recomendação, destacando a dimensão imagem/reputação da academia.
Implicações da Pesquisa: Em um mercado competitivo, é importante que os clientes estejam satisfeitos com os serviços prestados por uma empresa e sejam leais a ela, possibilitando o comportamento boca-a-boca na busca de novos clientes. Assim, compreender a influência da confiança e de dimensões do valor percebido na intenção de recomendação é fundamental para desenvolver melhores estratégias de mercado e relacionamento.
Originalidade/Valor: No cenário atual, onde a procura por academias vem apresentando crescimento, torna-se importante o desenvolvimento de diferenciais, pois com a padronização de serviços e competição de preços, os interessados em adquirir os serviços buscam algo diferente para suprir necessidades, possibilitando que o vínculo seja mais duradouro.
Vibrations of Plates and Shells with Attached Mass
Authors: Sultanov L. U. , Garifullin I. R.
Published: October 2024

The problem of vibrations of plates and shells with a mass attached to the point was solved. A mathematical model was developed based on the hypothesis of nondeformable normals. The latter was used to derive a system of resolvable dynamic equations for the shell with a mass, where the unknowns are the dynamic deﬂection and stress function. The problem was solved numerically and analytically. In accordance with the boundary conditions, the shell deﬂection was expressed as double trigonometric series. The transition from the initial dynamic system to the solution of the ﬁnal system of nonlinear ordinary diﬀerential equations was achieved by the Bubnov–Galerkin method. For time integration, the ﬁnite diﬀerence method was used.
ARCH-COMP24 Category Report: Continuous and Hybrid Systems with Nonlinear Dynamics
Authors: Geretti Luca , Alexandre Dit Sandretto Julien , Althoff Matthias , Benet Luis , Collins Pieter , Forets Marcelo , Mitsch Stefan , Schilling Christian , Tillet Joris , Wetzlinger Mark
Published: October 2024

We present the results of a friendly competition for formal verification of continuous and hybrid systems with nonlinear continuous dynamics. The friendly competition took place as part of the workshop Applied Verification for Continuous and Hybrid Systems (ARCH) in 2024. This year, 5 tools participated: Ariadne, CORA, DynIbex, JuliaReach and KeYmaera X (in alphabetic order). These tools are applied to solve reachability analysis problems on six benchmark problems, two of them featuring hybrid dynamics. We do not rank the tools based on the results, but show the current status and discover the potential advantages of different tools.
ARCH-COMP24 Category Report: Continuous and Hybrid Systems with Linear Continuous Dynamics
Authors: Althoff Matthias , Forets Marcelo , Schilling Christian , Wetzlinger Mark
Published: October 2024

We present the results of the ARCH1 2024 friendly competition for formal verification of continuous and hybrid systems with linear continuous dynamics. In its eighth edition, two tools participated to solve eight different benchmark problems in the category for linear continuous dynamics (in alphabetical order): CORA and JuliaReach. This report is a snapshot of the current landscape of tools and the types of benchmarks they are particularly suited for. Due to the diversity of problems, we are not ranking tools.
Stability Verification of an Industrial Switched PI Control Systems
Authors: Basagiannis Stylianos , Battista Ludovico , Becchi Anna , Cimatti Alessandro , Giantamidis Georgios , Mover Sergio , Tacchella Alberto , Tonetta Stefano , Tsachouridis Vassilios
Published: October 2024

Benchmark Proposal: In this paper, we propose a benchmark that addresses the chal- lenge of verifying Global Asymptotic Stability for a switched control of a turbofan engine. The control switches among two Proportional-Integral (PI) controllers and is parametrized by the reference values used to stabilize the output. We formulate the mathematical model as an affine switched system with a parametric affine term. The verification problems are, on one hand, to prove symbolically the stability of the system for specific reference values, and, on the other hand, to synthesize a region of parameters for which the stability is guaranteed. We report on previous works partially solving these problems.
Randomized Generation of Arbitrarily Difficult Verification Benchmarks for Linear Time-Invariant Systems
Authors: Wetzlinger Mark , Althoff Matthias
Published: October 2024

Benchmark proposal: The verification of uncertain linear systems is a fundamental building block for the analysis of complex cyber-physical systems. While there exist many advanced tools for numerical analysis, their evaluation is to date limited by selected bench- marks. To better understand the strengths and weaknesses of formal verification algorithms for linear systems, we propose a randomized generation of verification benchmarks in this paper. To this end, we leverage a reachability algorithm that can compute reachable sets with arbitrary precision. By placing unsafe sets exactly at the boundary of the computed outer and inner approximations, we are able to generate random verification tasks of ar- bitrary difficulty by changing the precision of the reachability analysis. We validate our approach by verifying and falsifying increasingly complex generated benchmarks using a state-of-the-art verification algorithm.
BACTERIAL REMEDIATION AND PROSPECTS FOR ITS UTILIZATION (REVIEW)
Authors: Sizencov A. , Sal'nikova E.
Published: October 2024

The escalating technogenic burden on the environment has adverse effects on ecological systems at various levels. Heavy metals significantly contribute to environmental contamination due to their strong biological impact and cumulative properties. The search for new methodological approaches to mitigate the consequences of technogenic pollution induced by heavy metals is an urgent task for ensuring the environmental sustainability of the region. Physical and chemical remediation techniques have several drawbacks, such as high costs and incomplete removal, which can lead to secondary contamination. Bacterial remediation is a highly efficient method that ensures a reduction in the level of human-induced pressure on the ecological system: bacteria – water – soil – plant – animal – human. The article examines meta-analytical data on the mechanisms of interaction between bacterial cells and metals, as well as methods of soil bioremediation and assessment of the sorption characteristics of microorganisms from the genus Bacillus sp. The results of empirical studies presented in the review demonstrate significant bioremediation potential of representatives of this group towards essential and xenobiotic elements from the group of heavy metals. Thus, the level of mercury sorption from substrates can reach up to 96.40 % of the applied concentration, lead – up to 99.5 %, cadmium – 98.3 %, arsenic – 98.3 %, nickel – 99.2 %, chromium – 95.0 %, copper – 91.8 % and zinc – 87.0 %, respectively. The research focuses on developing alternative methods that are not only highly efficient but also environmentally friendly for remediating areas affected by human-induced stress, by utilizing bacterial cell populations. The majority of the analyzed works studies use indigenous strains the tolerance to metals and sorption capacity of which are determined by their selection characteristics under conditions of excessive cationic load of metals on their environment.
PECULIARITIES OF ANTHECOLOGY OF ORCHIS MASCULA (L.) L. (ORCHIDACEAE) IN CRIMEA: SPECIES COMPOSITION OF POLLINATES, MORPHOLOGICAL COMPATIBILITY OF FLOWERS AND POLLINATES, POLLINATION LEVEL, AND POLLINATOR ATTRACTION SYSTEM
Authors: Svolynskiy A. , Ivanov S. , Kuramova V.
Published: October 2024

The research of two Crimean cenopopulations located in the Karabel-Dag tract (mountainous Crimea) and on Mount Chakatysh (Southern coast of Crimea) revealed the peculiarities of the antecology of the male orchid Orchis mascula L. The comparison of morphometric parameters of inflorescences and flowers of the studied cenopopopulations specified a number of reliable differences in both qualitative and quantitative parameters. In particular, inflorescences in the Karabel-Dag tract contained fewer flowers with a denser arrangement of flowers in inflorescences, and the flowers exhibited larger sizes of the flower gape and shorter spurs. Fifty-seven specimens of bees of 13 species were captured on orchid flowers, including 9 individuals from 8 species recognized as hemipollinators of the orchid: Andrena nitida Müller ⃰, Osmia bicornis L., Anthophora plumipes Pallas ⃰, Bombus haematurus Kriechbaumer ⃰, Bombus hortorum L., Bombus pascuorum Scopoli, Bombus terrestris L. ⃰, Xylocopa valga Gerstäcker ⃰. Additionally, five other bee species were caught on the orchid flowers without hemipollinators: Andrena flavipes Panzer ⃰, Andrena lathyri Alfken ⃰, Eucera cf. nigra Lep ⃰., Eucera nigrescens Perez. ⃰ u Apis mellifera L. The morphological correspondence of bees of the latest 5 species to orchid flowers qualifies them as legitimate pollinators of O. mascula in Crimea. The species marked with an asterisk were recorded as pollinators of O. mascula for the first time. Furthermore, 14 additional bee species that were active during the flowering period of O. mascula in their habitats were recognized as potential pollinators based on the morphological compatibility of their head structures with the orchid flowers. Over three seasons of observation two studied Crimean cenopopulations of O. mascula demonstarted a stable and relatively high level of flower pollination – from 26 % to 53 %. The pollination level of O. mascula varied significantly across different seasons while exhibiting less variation between cenopopulations within a single year. Pollinators were attracted to O. mascula flowers by the brightness of inflorescences and by imitation of nectar-bearing plant species that bloomed concurrently with O. mascula. The obtained data suggest the existence of two ecological forms of O. mascula in Crimea: mountain-forest and south coastal.
PHYTOPATHOLOGICAL ASSESSMENT OF THE NIKITA BOTANICAL GARDEN ARBORETUM AND PREDICTION OF THE DEVELOPMENT OF PATHOGENIC ORGANISMS
Authors: Isikov V. , Trikoz N. , Sharmagiy A.
Published: October 2024

In the Arboretum of the Nikita Botanical Garden 30 species of pests, 739 specimens (foci) (74 %); 34 species of pathogens of fungal diseases, 211 specimens, 21 %); including: 22 species of tinder fungi, 143 specimens. (14 %); 6 species of powdery mildew mushrooms, 41 specimens (4 %); 4 types of rust fungi, 19 specimens (2 %); 2 types of leaf spots, 8 specimens (1 %); 1 species of flower semiparasites, 50 specimens (5 %). were identified. The total number of damaged and affected tree introductions is 1000 specimens. The number of damaged plants in 2023 decreased by 26 % compared to 2022: the number of foci of Icerya purchasi, Pulvinaria floccifera, and Cydalima perspectalis decreased by 55 %, 49 % and 28 % respectively. Four new species of pests were identified with a total of 72 damaged woody plant specimens, where Acrocercops brongniardella dominates (61 specimens). The number of plants damaged by Paysandisia archon increased by 93 %: from 6 specimens in 2022 up to 84 specimens in 2023. For other types of pests, there was no increase in damaged plants. In Arboretum, 22 species of xylotrophic basidiomycetes were identified; the number of woody plants affected by tinder fungi was 143 specimens. Fuscoporia torulosa dominates among host plants, 92 affected trees. The number of phytopathogenic fungi species increased by 5 species compared to the previous year: Byssomerulius corium, Gloeophyllum abietinum, Coprinus micaceus, Lentinus lepideus, Ganoderma cupreolaccatum. The number of species of plants affected by tinder fungi in 2023 did not change and remained 58 species. Six species of powdery mildew fungi were identified on 7 species of woody plants, affecting a total of 41 plants. Four species of rust fungi were identified on 5 plant species, affecting 19 plants. Fungi causing leaf spots were identified in 2 species on 2 taxa of plants, the total number of affected plants was 8 specimens. The number of plants affected by the flower semiparasites Arceuthobium oxycedri remained 50 specimens; the number of affected plants did not change over the past 5 years. In 2023, 171 specimens of 55 introduced woody plant species died in Arboretum: the number of dead plants increased by 130 specimens compared to 2022. The pests – Icerya purchasi and Cydalima perspectalis – killed 104 specimens (61 %). 54 specimens (31 %) suffered from climatic drought and unfavorable environmental factors. Two specimens died from a Arceuthobium oxycedri and one specimen – from root rot. The authors identified four invasive pest species in the Arboretum of the Nikita Botanical Garden: Paysandisia archon, Cydalima perspectalis, Icerya purchasi, Acrocercops brongniardella; the biology and ecology of the discussed species were studied.
ECOLOGICAL ASSESSMENT OF PARK FOREST ECOSYSTEM ELEMENTS IN KLINTSY, BRYANSK REGION
Authors: Levkina G. , Svyatnoy E.
Published: October 2024

Due to the strong anthropogenic impact on the environment, the problem of the rational use of natural resources, including recreational ones, is very acute. The research was carried out in spring-summer of 2022 to assess the ecological state of the ecosystem elements of the Park Forest in Klintsy (Bryansk region) in order to justify giving this territory a protected status. The area of the study site was 45.16 hectares. The research included environmental monitoring, geomorphological, soil and floristic surveys. Recreational load and other indicators of anthropogenic impact on forest ecosystems were assessed. The Park was divided into several sections, taking into account the peculiarities of the state of natural components, depending on natural and anthropogenic influences. Convex landforms, historically chosen for development of park areas, prevail. Geomorphologically, the area belongs to the third group of morphogenetic relief types – glacial and glacio-fluvial accumulative mid-Quaternary plains. The predominant anionic composition of groundwater is hydrocarbonate. Based on the description of the soil profile, the presence of weakly soddy weakly podzolic cohesive sandy soil was revealed on deposits of overlying moraine loam and fluvioglacial sands with thin interlayers of red-brown moraine. This terrain can be classified as the typological group of terraines: zandra and moraine-zandra plains. In general, the territory of the park belongs to the class of recreational anthropogenic landscapes. When studying the floristic composition, it was noted that the park is located on the territory of an island forest massif, the indigenous types of which are wood sorrel pine forest and lichen heath pine forest. At present, the indigenous forest communities are significantly modified. The authors identified factors that have a negative impact on park forest ecosystems, in particular increased recreational pressure. It was concluded that in order to preserve the forest area within the urban environment, it was necessary to give the area a protected status.