bluuebunny/crossref_metadata_2025 huggingface dataset:
CLOUD LARIISA: A CONTEXT-AWARE FRAMEWORK FOR A PUBLIC HEALTH ENVIRONMENT BASED ON CLOUD COMPUTING CONCEPT
Authors: Oliveira Antonio Mauro Barbosa de
Published: September 2023

LARIISA is a framework that makes use of context-aware and ontology technologies to support decision making and governance in the public health sector. It is able to perceive the status of epidemiological emergencies and adapt itself in real time to a risk situation. This paper presents the LARIISA's cloud computing version, LARIISA's second rendition, whose main aim is to provide a software platform enabling the “facilities-like” offering of healthcare infra-structure, middleware and applications. It will also provide features to facilitate the description, publication, discovery and integration of both public and private healthcare software systems in an open way.
Metode Evaluasi Tipologi Street Front
Authors: Buwono Ruth Aureline Marsha , Sunaryo Rony Gunawan , Hariyanto Agus Dwi
Published: September 2023

Title: Street Front Typology Evaluation Method; The Case of Kembang Jepun, Surabaya
 
The Kembang Jepun district is one of the old districts of Surabaya. Located on the banks of the Kalimas River, Kembang Jepun determines the pulse of trading activity in Surabaya. As a vital district in Surabaya, the district needs to maintain its image and vitality in its corridors. The quality of the street front is all the things and activities that occur in city corridors, between buildings and roads. The street front is one of the main factors in determining the image and life of the district. This study aims to determine the street front quality in Kembang Jepun, to identify the parts of the district with the best and worst quality of the street front, and to classify the determining elements of the quality of the street front. This study uses descriptive qualitative method research. The analysis found that the Kembang Jepun district is classified as a district with a low skewed street front quality. Jalan Kembang Jepun corridor, an arterial road for Surabaya City with high connectivity, was found to have the best street front quality. Then, Jalan Kalimas Utara Corridor facing Kalimas River, is the road with the worst street front quality. The determining elements of the quality of the street front include the quality of the building facade, the presence of pedestrian paths, activities in front of the building, building openings, and road connectivity.
Life Cycle Cost Analysis of Pavement Using BIM: Review
Authors: M Parvathy S , G Sai Niveditha M , Krishna Apoorva
Published: September 2023

The methodology of Life Cycle Cost Analysis (LCCA) for road pavements and proposes the integration of Building Information Modeling (BIM) to enhance the analysis process. LCCA involves estimating the total cost of a project by considering initial construction costs, operational expenses, and maintenance costs. To minimize the life cycle cost of pavements, it is crucial to address the original cost alongside the requirements for pavement preventive maintenance. The study highlights the utilization of Economic and Sensitivity Analysis to examine LCCA results using key financial indicators such as Net Present Value (NPV) and Internal Rate of Return (IRR), considering various influential input parameters. By employing software instead of manual estimation, the potential for human error is significantly reduced while saving time. Furthermore, the study emphasizes the growing adoption of BIM in the field of infrastructure and proposes the integration of LCCA within the BIM environment. This integration aims to evaluate different design choices and establish effective maintenance plans. By utilizing BIM tools, a detailed analysis of the pavement's life cycle can be achieved, thereby facilitating the prediction of sustainable pavement solutions through the comparison of alternatives. In conclusion, this work contributes to the advancement of sustainable pavement practices by offering a comprehensive approach that combines LCCA, Economic and Sensitivity Analysis, and BIM. The proposed methodology has the potential to enhance decision-making processes related to road pavement construction, maintenance, and cost-effectiveness, leading to more efficient and sustainable infrastructure development.
Numerical Evaluation of Alkali Activated Reinforced Geopolymer Concrete Column
Authors: N Ajmal S , Raju Thushara , P Ramaswamy K
Published: September 2023

Geopolymer concrete is a type of concrete that is made by reacting aluminate and silicate-bearing materials such as fly ash or slag from iron and metal production with a caustic activator. It can be a suitable substitute for ordinary Portland cement (OPC) concrete. Geopolymer concrete is considered as green concrete since the reduced CO2 emission and due to the usage of waste materials for manufacturing. A lot of studies are undertaken in the field of the usage of geopolymer concrete in structural members such as beams, columns, slabs, etc. In this paper, geopolymer concrete columns are modeled using the Finite Element Modeling software ANSYS, and the behavior of the same column under axial loading and eccentric loading is studied. The axial behavior of the geopolymer concrete column is compared with the axial behavior of the conventional M30 concrete column and also the behavior of the geopolymer concrete column under axial load is compared with that of 50mm eccentric load.
Anomaly Detection of Streamflow Time Series Using LSTM Autoencoder
Authors: R Arathy Nair G , S Adarsh
Published: September 2023

Streamflow data obtained from the stream-gauge stations usually comprises of an ample volume of outliers. Anomaly detection is a requisite step in streamflow monitoring and analysis, especially in the context of water resources management, planning and flood risk studies. This study suggests a hybrid deep-learning anomaly detection method that combines an autoencoder and a long-short-term memory (LSTM) network. Multiple LSTM cells that collaborate with one another to understand the long-term dependencies of the data in a time series sequence make up the LSTM network. Based on the reconstruction error of the autoencoder's decoding phase, anomaly identification is accomplished. The applicability of the proposed method is demonstrated by considering the streamflow data (from 1985 to 2015) of Thumpamon streamgauge station of Greater Pamba River basin, Kerala. The hybrid framework exhibits promising results after computing the accuracy, precision, recall and the F1-Scores values as 99.51%, 100%, 89.89% and 94.73% respectively.
Fresh and Hardened Properties of Earth Concrete
Authors: Ravi Anjali , Vijay Aswin , Ittyeipe Alan Verghese , R. Sajeeb , P Ramaswamy K
Published: September 2023

The building sector is expanding daily on a global scale with several environmental problems. The implementation of sustainable methods in the sector is also becoming more relevant at the same time. Concrete is one of the most abundantly used building material, which is made up of fine and coarse aggregate held in place by cement paste. In the present study, soil is used as fine aggregate. Cement, soil and coarse aggregate are used in the proportion 1:0.85:3.60 to prepare the earth concrete. The study focuses on investigating the properties of the earth concrete in its fresh and hardened states. Workability, pulse velocity, and compressive strength are assessed to determine the performance of earth concrete. The effect of dosage of superplasticizer on the properties on earth concrete at fresh and hardened states is also studied. The findings shows that earth concrete is capable of achieving various relevant materialistic properties comparable to that of ordinary concrete and could replace normal concrete in certain applications.
Effect of Admixtures in Blast Furnace Slag-fly Ash Based Alkali-activated Paste
Authors: V. Aswani , Thomas Shobha Elizabeth , P Ramaswamy K
Published: September 2023

Portland cement can be replaced with alkali-activated binders (AABs), a sustainable material. They make use of industrial byproducts rich in aluminosilicates to produce hardened binders under alkaline conditions. The effective utilization of alkali-activated binders in each particular place is greatly influenced by the ease in accessibility of suitable precursors and activators. Slag-based AAB can make a strong and durable mix under ambient curing. But its poor workability and fast setting characteristics limit its scope of wide applications. The purpose of this investigation is to determine the effect of admixtures on the setting time of Alkali-activated Paste with blends of slag and fly ash (BFS-FA AAP). A combination of red gypsum and phosphoric acid is the admixture considered for the study. Setting time of BFS-FA AAP activated with sodium hydroxide and sodium silicate is studied considering different control factors, including Na2O/b ratio, BFS/binder and activator modulus (SiO2/ Na2O). The phosphoric acid, when added at 0.45 M along with red gypsum at 2.5% of binder content retarded the setting time of AAP effectively.
Effect of Ground Granulated Blast Furnace Slag in Limecrete with Added Natural Admixtures
Authors: K. Basithali E. , R. Sajeeb , P Ramaswamy K , Bhaskar Biju
Published: September 2023

Portland cement is typically used as the binder in concrete, which is a widely used building material. The high energy required as well as the CO2 emissions associated with the production of cement are considered to be serious environmental issues. The present paper considers concrete with lime binder (limecrete) which completely avoids the usage of cement. Mineral admixtures (pozzolanic materials) such as ground granulated blast furnace slag (GGBS), Rice Husk Ash, and Surkhi are used along with fermented organic admixtures such as Kadukkai and Jaggery. Brickbats are used as coarse aggregate and M-sand is used as fine aggregate. The focus of the present study is on finding the effect of GGBS on the properties of the limecrete considered. Compositions with different percentages of GGBS are used with lime along with natural admixtures. The different compositions of GGBS considered are 40, 60, 80, and 100 percentages by dry weight of lime. The liquid-fines ratio is fixed at 0.58 by trial and error. Four combinations of limecrete specimens are cast in standard cubic and cylindrical moulds. To assess the influence of the GGBS on various properties of the mix, specimens are tested for mechanical strength using destructive and non-destructive testing. Increase in GGBS content has found to increase the workability of limecrete. However, the 28th day compressive strength of limecrete is found to be low for structural applications.
Investigation on Aggressiveness of Organic Acids on Degradation of Ordinary Portland Cement Mortar
Authors: Ninan Chinnu Mariam , Radhakrishnan Ramu , Ramaswamy K. P. , Sajeeb R.
Published: September 2023

Vulnerability of concrete when exposed to low pH acidic environment is a phenomenon known for its significance in the durability of concrete structures. These hostile low pH acidic conditions attack the cement paste and disrupts the equilibrium of the matrix. Mortar specimens prepared with ordinary Portland cement (OPC) responds differently to various organic acid solutions. This study examines the acid aggressiveness on degradation of OPC mortar specimens exposed to 10% concentration lactic acid, acetic acid, citric acid and propionic acid. Acids with higher aggressiveness exhibits higher degradation. This paper compares the effects of different organic acids on cement mortar specimens in terms of mass changes, compressive strength changes and pulse velocity changes. Propionic acid and acetic acid show lower acid aggressiveness comparing to citric acid and lactic acid. Citric acid exhibits a consistency in its degradation and is of higher magnitude. The investigation of aggressiveness of organic acids on OPC mortar aids in predicting degradation to structures on acid exposure and hence preventing the eventual failure of the structure.
A Comparative Assessment of GIS Integrated ILP and MILP Techniques for Solid Waste Routing
Authors: Jose Nikhil , Mohan Gokul , Zayan Mohammed , Ali Mansoor , S Indu M
Published: September 2023

Municipal solid waste management is a growing issue all around the world. The transport of the solid waste is the major cost component in middle- and low-income group countries. Hence, optimizing the solid waste collection route is important. In this paper, optimizing the solid waste transport route was carried out using different algorithms (integer linear programming, and mixed integer linear programming considering the capacity of vehicle) and a comparative assessment of the results were carried out. The optimum route depends on the constraints induced and will vary according to capacity to be transported. The shortest route was 31.85 Km for Eicher pro-1080 and 41.77 Km for Tata Ace Mega.
Muhammed Kâsım Hindûşâh Esterabâdî’nin Târîh-İ Firişte’sinde Gazneli Dönemi Şairleri
Authors: ÖNTÜRK Vural
Published: September 2023

Gazneliler devri (963-1187) edebî bakımdan son derece önemli bir zamana tesadüf etmektedir. Sultanların her türlü koşulda edebî faaliyetleri desteklemesi, bu türün gelişmesini ve başta Şehnâme olmak üzere birçok kıymetli eserin kaleme alınıp günümüze kadar ulaşmasını sağlamıştır. Diğer ilimlerin yanı sıra şairlik de yine Gazneliler zamanında revaçta bir sanatsal faaliyet olarak karşımıza çıkmaktadır. Bilhassa Sultan Mahmûd döneminde hızlı bir gelişme gösteren şairlik ve şiir yazma geleneği bu tür ile uğraşanlar için aynı zamanda bir geçim kapısı olmuştur. Yalnız Sultan Mahmûd'un her daim dört yüz saray şairinin olduğu rivayet edilmektedir. Bu şairlerin hayatlarına dair bilgilere bazen kendi eserlerinde bazen de siyasî tarih alanında yazılmış kitaplarda tesadüf edilmektedir. Muhammed Kâsım Hindûşâh Esterabâdî tarafından kaleme alınan Târîh-i Firişte bu eserlerden birisidir. Deylem Bölgesi'nin şehirlerinden birisi olan Esterabâd'da dünyaya gelen ve bu sebeple Esterabâdî nisbesini alan şairin tam olarak hangi tarihte doğduğu belli değildir. Ancak tarihçiliğinin yanı sıra tıp alanı ile de uğraşmış olması iyi bir eğitim sürecinden geçtiğini göstermektedir. İlk eğitim hayatını tamamladıktan sonra Hindistan'da hüküm süren Nizamşâhî Hanedanlığı'na bağlı Ahmednagar şehrine gidip yerleşen Esterabâdî bir müddet sonra saraya girmeyi başarmış ve şöhreti de gittikçe artmıştır. Daha sonra Bîcâpûr'a gidip Âdilşâhî hükümdarı II. İbrahim b. Âdişâh'ın hizmetine girmiş ve onun isteği üzerine yazmaya başladığı Târîh-i Firişte'yi de tamamladıktan sonra kendisine ithaf etmiştir. Eserini bitirdikten sonra çeşitli elçilik görevlerinde bulunan Esterabâdî'nin 1033/1623 yılından sonra vefat ettiği tahmin edilmektedir. Bir mukaddime on iki bölüm ve bir hatimeden oluşan kitabın hemen başlangıcında Gaznelilere yer verilmiştir. Müellif Gazneliler Devleti'nin siyasî tarihini aktarırken yer yer sultanların tahtta kaldığı dönem ile mütenasip şairler hakkında da bilgiler sunmaktadır. Ancak bundan daha önemlisi Sultan Mahmûd devrinin (998-1030) sonunda aktarmış olduğu bilgilerdir. Zira bu kısımda sadece şairleri zikretmek için bir başlık açılmış ve Gazneli şairlerinin hayatlarından kısa kesitler ve şiirlerinden kısa örnekler verilmiştir. Bu çalışmada Esterabâd'nin hayatı, eseri ve eserinde geçen Gazneli devri şairleri hakkında bilgiler başka kaynaklarla mukayese edilerek verilmiştir.
Tarihi Mudurnu Kentinin Bellek Mekanları Olarak Kültürel Miras Değerleri
Authors: ACAR ATA İlknur
Published: September 2023

Kentlerin tarihinde toplumların sahip olduğu belleğin sürekliliğinin sağlanmasında etkin değerler bulunmaktadır. Bu değerler toplumun barınma, ticaret, ibadet, üretim ve tüketim faaliyetlerinin gerçekleştiği somut mekanları ve somut olmayan temsili mekanları kapsamaktadır. Toplumun hafızasında geçmiş ile gelecek arasında köprü niteliğindeki bellek mekanlarının varlığının toplum deneyimiyle yaşatılarak devamının sağlanmasına yönelik koruma çalışmaları bulunmaktadır. Özellikle UNESCO, ICOMOS gibi uluslararası kuruluşlar kültürel miras varlıklarının bellek değerlerinin sürdürülmesinde tarihi kent kimliğine uygun bütünleşik koruma sağlanmasına yönelik faaliyetler göstermektedir. Kültürel miras varlıklarının sahip olduğu özgün değerlerin içinde kent belleğindeki yeri kente dair birçok bilgi sunmaktadır. Kültürel miras varlıkları olarak tarihi yapılar yapıldıkları dönemden geleceğe bellek mekanı olarak kullanım değerlerindeki değişimlerle kolektif belleğinde değişken yapısını göstermektedir. Somut olmayan kültürel miras varlığı olan sözlü aktarımlar, gelenekler, anmalar, temsiller, el sanatlarının üretimi ve süreci, folklorik değerler geçmiş birikimin aktarılması odaklı bellek sürekliliğini sağlamaktadır.

Bu araştırmada sahip olduğu kültürel miras değerleri ile 2015 yılında UNESCO dünya mirası geçici listesine kabul gören Bolu İli'ne bağlı Mudurnu İlçesi’nin bellek mekanları incelenmektedir. Kent tarihi açısından birçok uygarlığın izlerinin sürüldüğü Mudurnu’nun gelişiminde Osmanlı döneminin etkisi günümüzde de görülmektedir. Kent İpek Yolu güzergahında olup, topoğrafyaya ve iklim koşullarına uyumlu geleneksel bir yerleşime sahiptir. Bellek mekanı olarak toplumun yaşama biçimini, geleneklerini, göreneklerini, sosyal ve ekonomik durumunu ortaya koyan geleneksel yerleşimin öğeleri cami, hamam, arasta, türbeler ve evlerin büyük bir bölümü kentsel sit kararları dâhilinde koruma altındadır. Kentin coğrafi konumu, yoğun olmayan nüfusu ve fiziksel gelişimine bağlı olarak yerleşimin tarihi özgün dokusu muhafaza edilmiştir. Bu durum kent belleğini oluşturan kültürel miras değerindeki somut ve somut olmayan varlıklarının günümüze dek gelmesini sağlamıştır. Çalışma kapsamında bellek mekanı olarak kentte Osmanlı dönemine ait günümüzde varlığını devam ettiren Yıldırım Beyazıd Camii ve Hamamı, Kanuni Sultan Süleyman Camii, tarihi Arasta, Saat Kulesi, yeniden kullanılan konaklar, türbeler ve çeşmeler ele alınmıştır. Ayrıca kentin UNESCO dünya miras geçici listesine kayıt olmasında etkin olan somut olmayan kültürel miras değeri ahilik geleneği de toplum kimliğinde aidiyet duygusu, ticaret felsefesi, zanaat üretimdeki rolüyle bir bellek mekanı olarak gösterilmiştir. Bu geleneğin aktarılmasına yönelik uygulamalara değinilmiştir.
An object of great archaeological value in the Museum of Mitrovica
Authors: HAJZERİ Pajazit , NAMANİ Kazım
Published: September 2023

Archeology is the science that allowed us to know the past of human societies and brought to light many exhibits, whether movable or static. However, random finds are just as valuable as those that are made with purpose and prepared, such as archaeological expeditions.

The Muse statue in Mitrovica was accidentally discovered during the excavation of the foundations for the construction of the city's gymnasium, but its value is extremely high since it is unique in Kosovo, while in other countries it is very rare.

The statue of the Muse is made of lead, which shows us that this region knew the processing of metals very early, it also gives us information that apart from exploitation, the craft of metal processing was also very well known.

The statue of the Museum in Mitrovica is one of the most precious exhibits that is kept in the city museum, this exhibit also has a special security, while its copy is presented to the public in the museum exhibition.
How does the Immunological System Change during the SARS-COV-2 Attack? A Clue for the New Immunotherapy Discovery
Authors: Hajihasani Mohammad Mahdi , Farkhad Najmeh Kaffash , Mahmoudi Ali , Sahebkar Amirhossein
Published: September 2023

The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-COV-2) is one of the biggest unsolved global problems of the 21st century for which there has been no definitive cure yet. Like other respiratory viruses, SARS-COV-2 triggers the host immunity dramatically, causing dysfunction in the immune system, both innate and adaptive, which is a common feature of COVID-19 patients. Evidence shows that in the early stages of COVID-19, the immune system is suppressed while it is overactive in severe patients characterized by excessive and prolonged inflammatory responses called "Cytokine Storm". There are many elements in the immune system that undergo alterations as the disease progresses. Some significant changes in the innate immune system following infection with SARS-COV-2 include delayed or inhibited interferon type 1 production by the infected cells leading to elevated virus replication, excessive recruitment of activated monocytes and macrophages, decrease in eosinophil population (eosinopenia), consequent decrease in CD8+T lymphocyte proliferation, natural killer (NK) cell dysfunction, and increase in neutrophil infiltration (neutrophilia) and neutrophil extracellular trap (NET) formation. Moreover, hallmark alterations in the adaptive immune system in this process cause an overall decrease in the T lymphocyte number (lymphopenia) and changes in the activity of some lymphocyte subsets and a number of B cells. This review delves into the mentioned changes in the immune system following SARS-COV-2 infection and the implications thereof to guide the development of immunotherapies for patients with COVID-19.
Computational Studies and Synthesis of New Heterocyclics as CNS Agents
Authors: Saini Pooja , Kumar Sushil
Published: September 2023

Aim:

This research work aimed to design and synthesize some new molecules of phenothiazine.
The work’s emphasis was on forming new phenothiazines in two series, 1-(10H-phenothiazin-
10-yl)-2-((4-(1-(phenylimino)ethyl)phenyl)amino)ethan-1-one derivatives (4a-4j) and 1-(4-((2-oxo-2-
(10H-phenothiazin-10-yl)ethyl)amino)phenyl)-3-phenylprop-2-en-1-one derivatives (P1-P5).

Methods:

Chloroacetylation of phenothiazine was done to afford 2-chloro-1-(10H-phenothiazin-10-
yl)ethan-1-one, which was further reacted with 4-amino acetophenone to produce 2-((4-
acetylphenyl)amino)-1-(10H-phenothiazin-10-yl)ethan-1-one. Then, it was treated with substituted
anilines and substituted benzaldehydes to produce the final derivatives 4a-4j and P1-P5, respectively.

Results:

All 15 derivatives (4a-4j and P1-P5) were characterized by evaluating their Rf value, melting
point, solubility, IR spectroscopy, and 1HNMR spectroscopy. Molecular docking was performed by
using AutoDock Vina v.1.2.0 (The Scripps Research Institute, La Jolla, CA, USA) docking software,
and the anxiolytic activity of the derivatives was assessed by using the elevated plus maze model.

Conclusion:

The designed scheme was executed in the departmental laboratory. The chemical structure
of the compounds was confirmed on the basis of TLC, IR, and 1HNMR analyses. The docking
study revealed a good docking score of the compounds. The Log P value of the compounds indicated
their good penetration into CNS. The compounds were also screened for anxiolytic activity. Among
them, compounds 4f, 4h, and P3 showed maximum activity as anti-anxiolytic agents.
Circulating MiR-1185¸ MiR-3183, and MiR-584 Levels in Plasma as
Diagnostic Non-invasive Biomarkers for Early Detection of Breast Cancer
Authors: Khalafi-Nezhad Abolfazl , Abdollahi Ahmad , Barazesh Mahdi , Amani Marzieh , Motazedi Setare , Ebrahimi Vahid , Zarei Ali
Published: September 2023

Introduction:

MicroRNAs (miRNAs) are non-coding RNA molecules with short sequences
that function as main post-transcriptional gene regulators of different biological pathways via negative
regulation of gene expression, thereby leading to either mRNA degradation or translational
blockade. Dysregulated expression of these miRNAs has been related etiologically to many human
diseases, including breast cancer. Various cellular processes of breast cancer progression, including
cell proliferation, apoptosis, metastasis, recurrence and chemodrug resistance, are modulated by oncogenic
miRNA (oncomiR).

Objective:

The objective of this investigation was to study the expression level and potential diagnostic/
prognostic roles of circulating microRNAs (miR-3183, miR-1185, and miR-584) as novel breast
cancer biomarkers.

Method:

The current study was conducted on 99 breast cancer (BC) female patients, aged between
20-63 years old, as the case group and 50 age-matched healthy females as control (HC). After microRNA
extraction from the serum samples, real-time PCR was carried out for relative expression
quantification of miR-1185, miR-3183a, and miR-584. The ROC curve analysis was performed to
investigate the diagnostic value of miRNAs.

Result:

It was demonstrated that miRNA-1185, miRNA-584, and miRNA-3183 were significantly
up-regulated (p-values <0.0001) in female BC cases compared to the control group. Besides, based
on the ROC analysis for BC versus HC, it was revealed that the AUC for miRNA-584 was 0.844
(95% confidence interval (CI) and could be proposed as a diagnostic biomarker for breast cancer
screening and follow-up.

Conclusion:

MiRNAs expression profiling using blood-based samples demonstrated their upregulation
in the serum and plasma and revealed the concept that circulating miRNAs have high potential as
novel noninvasive biomarkers for cancer diagnosis and screening.
Automatic Detection and Segmentation of Brain Hemorrhage based on
Improved U-Net Model
Authors: Phan Thuong-Cang , Phan Anh-Cang
Published: September 2023

Introduction::

Brain hemorrhage is one of the leading causes of death due to the sudden rupture of a blood vessel in the brain, resulting in bleeding in the brain
parenchyma. The early detection and segmentation of brain damage are extremely important for prompt treatment.

Methods::

Some previous studies focused on localizing cerebral hemorrhage based on bounding boxes without specifying specific damage regions. However,
in practice, doctors need to detect and segment the hemorrhage area more accurately. In this paper, we propose a method for automatic brain
hemorrhage detection and segmentation using the proposed network models, which are improved from the U-Net by changing its backbone with
typical feature extraction networks, i.e., DenseNet-121, ResNet-50, and MobileNet-V2. The U-Net architecture has many outstanding advantages.

Results::

It does not need to do too many preprocessing techniques on the original images and it can be trained with a small dataset providing low error
segmentation in medical images. We use the transfer learning approach with the head CT dataset gathered on Kaggle including two classes,
bleeding and non-bleeding.

Conclusion::

Besides, we give some comparison results between the proposed models and the previous works to provide an overview of the suitable model for
cerebral CT images. On the head CT dataset, our proposed models achieve a segmentation accuracy of up to 99%.
Lysosomal Storage Diseases: Natural Products Inducing Autophagy
Authors: Chandarana Chandani , Habshi Tahib , Soni Arun , Acharya Sanjeev
Published: September 2023

Background:

The link between autophagy and lysosomal function has been wellrecognised
in recent decades; defective autophagy and lysosomal function lead to various disorders,
notably Lysosomal Storage Disorders (LSDs). The malfunction of multiple mechanistic pathways influences
the contribution of LSDs. Different ways are employed in such situations, but one novel approach
could resolve the problem by inducing the autophagic pathway, which aids in maintaining
proper autophagy and lysosomal degradation function.

Methods:

Autophagic Inducer functions on the activation of Transcriptional factor EB (TFEB) and its
mechanism; mTOR Complex Inhibition dependently or independently may repair the malfunction of
the entire mechanism. Finding a potential autophagic inducer is still a work in progress, but targeting
TFEB and mTOR could redefine LSD treatment. The development of experimentally available TFEB
modulators could enhance autophagic flux promote lysosomal function and increase lysosomal biogenesis
and can be a promising technique for treating illnesses caused by ALP dysfunction, such as
lysosomal storage disorder.

Results:

MTORC1 suppression causes TFEB to be transported to the nucleus and transcription of multiple
genes involved in the formation of autophagosomes and lysosomes, indicating that MTORC1 has
positive effects in treating lysosomal storage diseases such as Pompe disease, Batton disease, Fabry
disease, etc. thus modulating autophagy attenuates the above condition.

Conclusion:

This review comprises autophagy and lysosome association, and their malfunction leads
to various lysosomal diseases. Several natural products are also discussed, which can be possible
treatment options.
Evolution of Nuvoton Microcontroller-based Education Board
Authors: Elp Hudaverdi Emin , Inan Remzi
Published: September 2023

Background::

The novel coronavirus pandemic has not only affected people's health. The
pandemic has also affected their social life and work. For all the reasons mentioned, international
trade has suffered and is still in the process of recovery.

Objective::

Especially in the semiconductor industry, many manufacturers postponed their deliveries
to future periods and this triggered the chip crisis. Many hightech industries, including the automotive
industry, were deeply affected by the consequences of the crisis, with factories halting or slowing
down production. Despite the shortage of chip stocks, Nuvoton has a large amount of Microcontroller
Units (MCUs), but due to the shortage of resources, education and libraries, software developers
have not been able to integrate their products in a limited time.

Methods::

In this paper, the Nuvoton Education Board has presented 20 common examples for embedded
software developers and beginners.

Results::

The PCB is designed considering all modules connected to separate General Purpose Input
Output (GPIO) pins to make multiple module examples without changing the peripherals and pin
configuration of the MCU. Clock configuration has been simplified and unnecessary details have
been meticulously removed to make the examples easily understandable. Nuvoton NuMaker
M263KI V1.3 was added on the designed PCB.

Conclusion:

The PCB contains almost all the necessary electronics to learn embedded software and
use Nuvoton MCUs in industrial projects. The board is supported with user interfaces and printed
documentation. The codes are explained with command lines to teach users even small details. A
patent application has been filed for the proposed education board.
Analysis of IoT Applications in Highly Precise Agriculture Farming
Authors: N. Latha Reddy , Masila P. Gopinath
Published: September 2023

Background:

The IoT (Internet of Things) assigns to the capacity of Device-to-Machine (D2M) connections, which is a vital component in the development of the digital economy. IoT integration with a human being enables real-time decision-making in communication, collaboration, and technology analytics. Furthermore, environmental factors impacting plants, such as air humidity, temperature, air quality index, and soil wetness, are not frequently documented, emphasizing the development of a data monitoring system for future agricultural research and development.

Methods:

An IoT-based Intelligent Farming System is proposed. An innovative IoT-based intelligent farming system is developed that integrates real-time data monitoring, machine learning algorithms, and IoT technology to address the identified gaps and challenges.

Result:

In the face of climate change, extreme weather, and environmental constraints, increased food demand must be satisfied. Intelligent agriculture enabled by IoT technology can reduce waste and increase productivity for producers and farmers, from fertilizer use to tractor trips.

Conclusion:

In conclusion, this paper provides insightful and informative commentary on the progress made in technology within the agriculture industry and the challenges that still need to be overcome to achieve optimal outcomes.
Role of Wearable Biosensors in Healthcare
Authors: Yadav Himani , Bhaskar Sharma Bhaskar Sharma , Goswami Ravi Kumar , Kumar Shrivastav Avanish , Chaturvedi Vivek K. , Uniyal Prem L. , Giri Priti
Published: September 2023

These days, wearable biosensors are a very valuable tool for tracking the
start of various acute and chronic diseases. Wearable biosensors (WBSs) are small,
electrical devices that coordinate and collect sensations into the human body and can be
present in the form of tattoos, gloves, clothing and inserts. WBSs are a flexible and
practical tool for use in the healthcare industry, thanks to their ability to detect
information, record it and estimate it accurately. WBSs help patients and doctors to
communicate in both directions. It is simple to do painless evaluations of bodily fluids
using various biochemical markers such as spit, sweat, skin, and tears. As the
continuous state of capabilities of wearable and adaptable sensors continues to
advance, the creation of new wearable gadgets that can fill the gap and handle the
advantage of human well-being checking and clinical application is advancing. Blood
is still the most crucial bio-liquid for assessing a person’s health, even though more
attention has been paid to other bodily fluids that are naturally secreted and severe
functions that are similar to those of blood. There has been a lot of interest in the
capacity of compact biosensing devices to identify the analyte in bio-liquids for the
early detection of human well-being.
Biosensors for Protein Bio-Sensing and Detection of Bacteria and Viruses
Authors: Yadav Himani , Sharma Bhaskar , Giri Priti , Kumar Shrivastav Avanish , Kumar Chaturvedi Vivek , Uniyal Prem L. , Kumar Goswami Ravi
Published: September 2023

The concept of a biosensor was first proposed in 1962 by Clark and Lyons,
who developed an oxidase enzyme electrode for the detection of glucose. Since then,
the development of nanotechnology has prompted biosensors to evolve and become
more specialized for a variety of applications. Currently, at the forefront of science,
bio-sensing applications combined with nanotechnology have implications for multiple
fields, including medicine, biology, environment, drug delivery, and food safety. In
recent decades, bacterial and viral diseases have seriously threatened human safety.
Prioritizing the rapid detection of outbreaks, which pose a major threat to the
healthcare system and could have a catastrophic socioeconomic impact, will help stop
them. Scientists are conducting extensive research to develop sensitive diagnostic
techniques and effective medicines.
Theory of Thermal Explosions
Authors: Fabbricino Massimiliano , Andreozzi Roberto , Clarizia Laura , Cesaro Alessandra , Policastro Grazia , di Giovanni Concetta
Published: September 2023

The theory on thermal explosions according to Semenov’s approach is thoroughly
described in this chapter. The main calorimetric tests to be carried out for a safe thermal analysis
are also reported. The thermal inertia is defined and its effects on the characterization of reactive
chemical systems is evaluated.
Heterogeneous Explosions II
Authors: Fabbricino Massimiliano , Andreozzi Roberto , Clarizia Laura , Cesaro Alessandra , Policastro Grazia , di Giovanni Concetta
Published: September 2023

Flammability limits depend on different parameters, such as pressure and flame
propagation direction. In the present Chapter, Le Chatelier’s equations and the Flash Point and
Upper temperature are presented. The Minimum Oxygen Content is also defined.
Toxicology and Industrial Hygiene
Authors: Fabbricino Massimiliano , Andreozzi Roberto , Clarizia Laura , Cesaro Alessandra , Policastro Grazia , di Giovanni Concetta
Published: September 2023

In this chapter, the main routes of exposure to toxic chemicals and methods of
eliminating them by the human body are presented. In particular, both defense and
biotransformation mechanisms are described. The threshold limit values (TLV) and Material
Safety Data Sheets are also introduced.
The Risk Assessment Applied to Industrially Contaminated Sites
Authors: Fabbricino Massimiliano , Andreozzi Roberto , Clarizia Laura , Cesaro Alessandra , Policastro Grazia , di Giovanni Concetta
Published: September 2023

Emissions of dangerous substances from ordinary industrial activities or industrial
accidents may compromise the quality of soil and water. Indeed, industrial sites can be
contaminated by a wide range of compounds, which represent a risk to the health of workers.
To individuate whether the presence of contaminants represent a risk and how it is possible to
remediate contaminated sites, it is necessary to apply the Risk Assessment technique. Risk
assessment allows evaluation of the risk associated with the presence of contaminants, as well
as remediation goals. The present chapter provides fundamentals on the risk assessment
procedure applied to industrial contaminated sites. The main object is to provide a methodology
to individuate contaminated sites and evaluate the remediation goals. To this aim, the main
contents of the chapter are: basic concepts on contaminated sites, a description of the risk
assessment method, an overview of the possible remediation techniques. Moreover, a practical
exercise as well as a list of the most used software are provided.
Rethinking of Local Autonomy and Fiscal Decentralization Policy: Can It Improve The Quality of Human Capital? A Case in Eastern Region of Indonesia
Authors:   Universitas Brawijaya, Prayoga Fahmi , Ananda Candra Fajri
Published: September 2023

Purpose This study aims to see the effect of regional autonomy and fiscal decentralization in the fields of education, health, and the economy in the development of human resources in Eastern Indonesia. Design/methodology/approach This study uses a quantitative approach with panel data regression utilizing data from 16 provinces in Eastern Indonesia from 2010-2019. Findings According to the results, the development of human resource quality is influenced by government spending on education, health, and GRDP per capita. However, the study reveals that capital expenditure does not play a significant role in the enhancement of human resource quality. Research limitations/implications One shortcoming of this research is its lack of detailed information regarding how capital expenditures, education expenditures, and health expenditures are distributed across various local governments. Originality/value This study shows the impact of fiscal decentralization and regional autonomy by comparing the results gap that occurs between the western and eastern regions of Indonesia on human resource development
The Financial Behavior of Young Generation in Indonesia
Authors:   Management Department, Faculty of Economics and Business, University of Brawijaya, Indonesia, Kurniasari Irma , Sumiati Sumiati , Ratnawati Kusuma
Published: September 2023

Purpose This study explored self-efficacy's link to student financial behavior, assessing its influence and dimensions. The aim was to improve financial literacy and behavior among students through interventions. The study deepened understanding of self-efficacy's role in university students' financial behavior. Design/methodology/approach In quantitative research, researchers employ SEM, specifically PLS, to examine self-efficacy and financial behavior in university students. The study has 100 student respondents and uses SEM-PLS for complex analysis, aiming to offer empirical evidence for hypotheses. Findings could significantly enrich comprehension of self-efficacy's influence on financial behavior in college students. Finding Results show a positive link between variables. Higher self-efficacy relates to improved financial behavior. Confident individuals budget, save, and make wise financial choices. This underscores the need to enhance self-efficacy in interventions for better student financial behavior. Overall, findings emphasize self-efficacy's pivotal role in shaping financial behavior. Research limitations/implications This study offers empirical evidence of a positive link between self-efficacy and financial behavior, broadening understanding. It highlights psychological factors in financial behavior and extends self-efficacy's role in financial management literature. Financial education programs should enhance self-efficacy for better financial management, benefiting students' overall well-being. Originality/value This research merges self-efficacy and financial behavior concepts, showcasing the link between psychological factors and financial actions. Combining these constructs provides a holistic view of how self-beliefs impact financial choices and behaviors.
The Impact of Covid-19 Towards Education Expenditure: Evidence from China
Authors:   Risk Management Department, China Postal Savings Bank, Guizhou Branch, Yizhi Zhang , Rasli Amran ,   Inti International University, Malaysia
Published: September 2023

Purpose This paper aims to explore the impact of the COVID-19 epidemic on the study and life of graduate students, understand the current practical problems faced by effective graduate students, and explore the impact of the COVID-19 epidemic on the life of graduate students in universities. Design/methodology/approach In this paper, the graduate students of Guizhou University are targeted, and the specific impacts of COVID-19 on their personal safety, extra costs, self-control ability and employment are expounded. Findings The study founds that to support university graduate students during the prevention and control period, focus on establishing effective psychological support mechanisms and self-discipline development programs. Provide accessible counseling services and mental health awareness campaigns while enhancing resources to boost self-control and time management skills, especially for remote studying. Additionally, reinforce employment services with improved career guidance and job placement support, and address enrollment pressure through better communication and mentorship initiatives Research limitations/implications In this context, it is necessary to study the obstacles and problems brought by the COVID-19 epidemic to the study of graduate students in universities and try to resolve the adverse effects caused by the epidemic. Originality/value It points out various difficulties facing graduate students in universities under the background of epidemic prevention and control, and puts forward some appropriate suggestions based on the actual situation, so as to provide some insights for graduate students to understand how to deal with the negative effects of COVID-19
Pencegahan Penyakit Diabetes Melitus pada Masyarakat Desa Ngadiwono Kecamatan Tosari Kabupaten Pasuruan dengan DEM (Deteksi, Edukasi, dan Monitoring)
Authors:   Departemen Patologi Klinik, Fakultas Kedokteran, Universitas Brawijaya, Khila Firani Novi , Kurnia Permatasari Happy ,   Departemen Biokimia-Biomolekuler, Fakultas Kedokteran, Universitas Brawijaya, Pudjo Wahono Singgih ,   Departemen Biokimia-Biomolekuler, Fakultas Kedokteran, Universitas Brawijaya, Soraya Mira ,   Residen Program Studi Patologi Klinik, Fakultas Kedokteran, Universitas Brawijaya, Purnamasari Putri ,   Residen Program Studi Patologi Klinik, Fakultas Kedokteran, Universitas Brawijaya, Setya NIngtyas Denina ,   Residen Program Studi Patologi Klinik, Fakultas Kedokteran, Universitas Brawijaya
Published: September 2023

Penyakit Diabetes Melitus merupakan penyakit metabolik yang ditandai dengan peningkatan kadar gula dalam darah. Penyakit ini merupakan salah satu penyakit degeneratif yang berlangsung kronis, sehingga seringkali menyebabkan berbagai komplikasi. Komplikasi akibat Diabetes Melitus dapat menyebabkan meningkatnya angka kematian. Insiden penyakit Diabetes Melitus meningkat dengan bertambahnya usia. Oleh karena itu deteksi dini dan pengenalan faktor resiko penyakit Diabetes Melitus pada masyarakat usia lansia dan pralansia sangat penting dilakukan, supaya dapat mencegah penyakit ini sejak dini. Desa Ngadiwono, merupakan salah satu desa di kecamatan Tosari, kabupaten Pasuruan yang belum memiliki poliklinik maupun puskesmas pembantu sebagai salah satu layanan kesehatan yang penting sebagai usaha peningkatan kesehatan masyarakat, namun sudah memiliki Polindes dan Posyandu. Maka perlu dilakukan program pengabdian masyarakat ini sebagaisalah satu upaya dalam meningkatkan partisipasi masyarakat untuk pencegahan penyakit Diabetes Mellitus sehingga dapat meningkatkan derajat kesehatan masyarakat. Skrining penyakit Diabetes Melitus dilakukan melalui pemeriksaan kadar gula darah sewaktu. Selanjutnya dilakukan edukasi dengan ceramah kesehatan dan pemberian brosur. Tahapan terakhir yaitu monitoring, dengan melakukan pemeriksaan kadar glukosa darah kembali di akhir program. Sasaran program pengabdian masyarakat ini adalah masyarakat usia lansia dan pralansia di Desa Ngadiwono, Kecamatan Tosari, Kabupaten Pasuruan. Hasil kegiatan pengabdian masyarakat ini menunjukkan bahwa terdapat penurunan persentase warga yang memiliki kadar gula darah kategori Diabetes Melitus dari 10,67% menjadi 6,67%
Design Of Digitalization Of Lamong Bay Terminal Service System In Supporting Indonesian Sea Toll Program With Quality Function Deployment (Qfd) Approach
Authors:   Industrial Engineering, Faculty of Engineering Universitas Brawijaya, Indonesia, Nur Cahyawati Amanda , Kusuma L. Tri Wijaya N. , Sari Sylvie I. Kartika
Published: September 2023

Indonesia is a maritime country because it has a larger water area than land area. Indonesia has 17,499 islands that inhabit 3.25 million km2 of water from Sabang to Merauke. Therefore, sea transportation is one of the most important things that is used as a link between islands in Indonesia. Seaports are one of the most important parts of the marine transportation network in Indonesia in supporting the transportation of people and goods. Sea toll is a marine logistical transportation concept that aims to connect major ports in the archipelago. With this sea toll, it is hoped that it can reduce logistics costs andcan maintain the stability of the price of goods and commodities between regions. The purpose of this research is to design a digital platform to optimize port services to be more effective and efficient in entering the industrial era 4.0 which will have an impact mainly from minimizing national logistics costs, dwelling time, balancing distribution channels and product prices, and reducing differences in operating costs ports between regions. This study, using the QFD approach which has several stages of planning and development through a matrix, one of which is the House of Quality (HoQ) matrix. In this method, it is used to link Customer Requirements (CR) and Performance Standards (PS) to identify relevant PS that affect the effectiveness and efficiency of the port system to the specified CR. With the role of the digital platform system for the seaport operational system, especially in Teluk Lamong Terminal, so that all stakeholder representatives can provide advice according to their institutional interests regarding the Indonesian sea highway program and solve it only in the mobile phone application. Based on the calculation of the House of Quality (HoQ), it can be analyzed that each technical response has a priority level so that it can be determined which attributes should be developed first. The technical response which is the first priority is system integration between stakeholders, the second priority is application data security, and the third priority is the dock activity information feature.
Konstruksi Identitas Nasional Pada Masyarakat Adat: (Studi Kasus Di Kampung Naga Desa Neglasari Kecamatan Salawu Kabupaten Tasikmalaya)
Authors: Nurohman Taufik , Gunawan Hendra
Published: September 2023

This study examines the construction of national identity in indigenous peoples in Indonesia. This national identity is a form of social identity or collective identification which describes the attachment of group members to the state expressed with a sense of belonging, love, loyalty, pride, and protection of the group and its homeland. This national identity discourse is often an issue that is vulnerable to being discussed and debated in a society that has its own peculiarities such as indigenous peoples. These indigenous people have cultural identities, value systems and knowledge, living areas, and ways of interacting which are often different from other communities, so that they need different treatment in terms of building their national identity.