bluuebunny/crossref_metadata_2025 huggingface dataset:
Study on autonomic nervous system activity with compression socks on lower limbs in isotonic exercise
Authors: Nakamura Hideo
Published: June 2021

The benefits of exercise have been widely recognised for a long time. Exercise increases heart rate, in turn facilitating the effective flow of oxygen and blood around the body and enabling the muscles to use this oxygen and blood in economically beneficial ways. Dr Hideo Nakamura,
Department of Health Promotion and Sports Science, Osaka Electro-Communication University, Japan, is exploring the importance of lower limb compression socks for measuring autonomic nervous system (ANS) activity. ANS is a key regulator of the cardiovascular system and helps regulate heart
rate and blood pressure. Nakamura is filling a research gap as there is little scientific consensus on the effects. A key focus for Nakamura and his team is on the significance of compression socks for sports to measure ANS activity with heart rate variability during exercise. Nakamura is
building on previous studies utilising Tone-Entropy analysis, which is effective as it has high reproducibility and high reliability. Using this method, the researchers will explore mental stress, effects of exercise, pharmacological effects and meditation, among other things. The team used
a bicycle ergometer to observe heart rate and ANS activity and found that rhythmic exercise could promote improved blood flow in the veins through compression of the lower limbs. Ultimately, the team hopes to define the subtle differences in parasympathetic nervous activity in individuals
wearing compression socks.
Elucidation of the mechanism of stereoscopic insufficiency and mental and physical fatigue caused by near vision - research and development on recovery methods
Authors: Takahashi Satoshi
Published: June 2021

Increased exposure to video terminal display (VDT) devices is part of 21st century life, but the consequences of this are myopia and abnormal binocular single vision, which present as mental and physical fatigue. A collaborative team is investigating the mechanism underlying abnormal
binocular single vision and developing a methodology for recovery. Associate Professor Satoshi Takahashi, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Japan, and the tem are looking into the interaction between binocular stereoscopic clues
and monocular stereoscopic clues in binocular single vision. Their goal is to explore the effects on depth judgment and the researchers will use their findings to construct a training system that enables correct depth judgement in binocular single vision. This extensive research will involve
conducting inspections on a large number of participants and developing effective methods for inspecting binocular stereoscopic function. This will lead to the development of a device that can easily diagnose the binocular stereoscopic function of the participants and enable early detection.
Takahashi and the team will also explore training methods that can help individuals recover lost eye function and encourage behavioural changes that will reduce incidence of eye problems.
Design for the visually impaired when traveling outdoors using omnidirectional imagery and image recognition
Authors: Baba Tetsuaki
Published: June 2021

Assistive technologies, such as devices to help perform tasks, cognitive aids, mobility aids, physical modifications in the built environment and closed captioning, help to improve or maintain a person's ability to complete day-to-day tasks. For example, assistive technologies can be
helpful for people with disabilities or the elderly, enabling them to work around challenges they may encounter. The development of assistive technologies depends on datasets, which are used for training, testing or validation. Furthermore, making such datasets widely available can help advance
the field of assistive technologies. One area in which assistive technologies can be useful is in helping people who are visually impaired. For example, electronic mobility aids use ultrasonic waves that reflect off objects in front of people, letting them know what is ahead. At the Division
of Industrial Art, Faculty of System Design, Tokyo Metropolitan University, in Japan, Associate Professor Tetsuaki Baba is using a deep learning approach to develop assistive technology for visually impaired people. As a foundation for this work, he and his team have developed a dataset for
developers to create deep learning vision-based applications for visually impaired people.
THE FACTORS OF THE LATERAL ORIENTATION OF PORTRAITS
Authors: Pejić Biljana , Škorc Bojana
Published: June 2021

This paper analyses the portraits` aesthetic experience from side perspectives, including left and right orientation. Research was conducted by performing two experiments. The first experiment included 40 participants, the second had 26 participants of both genders who were not trained in the field of fine arts. The stimuli were 12 reproductions of portraits, profile orientation, of models made by famous painters. All the portraits represented adult persons, of different genders (male or female), spatial orientation (left or right) of the model and form (original or inverted). The participants assessed the presented portraits without time limitation on six scales, which measured two dimensions of aesthetic experience: evaluation and activity.The results support the hypothesis claiming that left side orientation (looking to the left) is valued higher with female portraits, while right side orientation with male portraits is valued higher. It has also been shown that the given differences in estimation were stable, keeping values in the same trend when the portraits were being inverted along a vertical axis.
LIVED EXPERIENCES OF WOMAN IN RELATION TO INFERTILITY – A REVIEW OF THE QUALITATIVE RESEARCH
Authors: Janković Ivana , Todorović Jelisaveta
Published: June 2021

In this article, we have analyzed the experiences of women with infertility. We were interested in what we can learn about their feelings, thoughts and problems by analyzing the results obtained in qualitative research. We analyzed 10 qualitative studies dealing with infertile women. Using the thematic analysis, we identified seven core themes: Motherhood, Stories of Infertility, All Colors of Feelings, Changes in Identity, Complexity of Partnership, Social Environment (Social Support), Coping Strategies. Each selected core theme includes a number of subthemes. The article explains in detail each selected theme, and their justification is supported by appropriate quotations.
CANCER, FERTILITY, AND PSYCHOLOGICAL DISTRESS
Authors: Kesić Vesna
Published: June 2021

The number of young women treated for cancer who want to give birth is increasing, due to postponing pregnancy for older age. On the other hand, the disease is more often diagnosed in the early stage, when conservative treatment is much more successful, even in gynecological cancer. Most young women diagnosed with cancer can expect to live for decades after treatment, which makes many life issues, such as future fertility, increasingly important.  This has led to the separation of Oncofertility as a new field in oncology, which includes all procedures for the treatment of malignant disease with the aim of preserving fertility, but without compromising the oncological outcome. And while the problem of fertility may not be a priority at the time of diagnosis, over time it becomes more important. Infertility resulting from cancer treatment has a major impact on quality of life. The turmoil experienced by women who are simultaneously faced with cancer and possible loss of fertility leave emotional consequences, especially if the localization of the disease directly affects the reproductive organs. Coping not just with medical issues, but with two psychological traumas at the same time increases susceptibility to distress. Helping to preserve the quality of life and the psychological aspect of caring for patients with malignant diseases who want to preserve the possibility of childbirth should become an indispensable part of treatment. Recognizing and managing negative emotions in cancer patients is a priority that aims to improve their quality of life.
GEOTHERMAL ENERGY RESOURCE POTENTIAL IN NIGERIA FROM AEROMAGNETIC REVIEWS: ANOTHER PANACEA FOR ENERGY CRISES AND ENVIRONMENTAL GLOBAL WARMING
Authors: Nwankwo Levi Ikechukwu
Published: June 2021

An effort has been made in this paper to advocate a panacea to the prevailing energy crisis in Nigeria by reviewing the country’s geothermal energy resource potential from regional aeromagnetic calculations. There is widespread occurrence of warm/hot springs in Nigeria, which gives credence to the availability and abundance of geothermal reserves. Results of aeromagnetic investigations also confirm that areas with anomalous high heat flow exist in Nigeria, showing high prospects of employing geothermal energy for direct and indirect energy applications. It is, therefore, imperative for Nigeria to take a quantum leap in holistic renewable energy research and development through appropriate government science advice, policy and environmental management.
POTENTIAL HEALTH IMPACT OF DRINKING WATER SOURCES: CASE STUDY FROM SERBIA
Authors: Lazarević Vesna , Đorđević Miodrag , Đorđević Nataša , Igić Nikola , Stojković Ana , Krstić Ivan
Published: June 2021

Drinking water quality has a direct impact on the health of the population and is the main indicator of environmental sanitation and hygienic living conditions. The aim of this study was to investigate the quality of drinking water from three water supply systems in Serbia.The retrospective descriptive study was done covering the period between 2011 and 2015. We collected data from control water supply systems in three towns and tested the samples as required by the Regulation on the Hygienic Acceptability of Potable Water. The following indicators of water security were analyzed: ammonia, nitrates, nitrites, consumption of potassium permanganate, organic matter content, pH and electroconductivity. The microbiological quality was determined by analyzing the indicators of fecal contamination, Escherichia coli, Enterococci and Salmonellae, using the membrane filtration method.The most frequent parameters of physical-chemical insecurity of water were a high concentration of ammonia, lower pH levels, and increased consumption of potassium permanganate. The most common detected microbes were aerobic mesophilic bacteria which are not significant from the aspect of human health.These results showed that drinking water could pose a potential risk to local consumers.
ANALYSIS OF RISK AND NO-RISK INTERVENTIONS BY MEMBERS OF FIRE AND RESCUE UNITS UNDER MULTI-RISK CONDITIONS
Authors: Božović Marijola , Mihajlović Emina , Živković Nenad , Živković Snežana
Published: June 2021

The issue of occupational safety and health of the members of fire and rescue units has been continuously studied by numerous authors. Their interest stems from the constant need to improve the methods and procedures of occupational safety and health assessments for fire and rescue unit members, all for the purpose of preventing injuries, primarily the fatal ones. The fact that a certain number of high-risk situations in which firefighters avoid an injury or death remain unreported poses a serious threat to the firefighters’ safety. This threat has been unjustifiably neglected and it is what motivated the research discussed in this paper, which reveals the results of three discriminant analyses.
THE IMPORTANCE OF COMMUNICATION IN AN EMERGENCY
Authors: Đukić Sandra , Novaković Nataša , Živković Snežana
Published: June 2021

Communication, regardless of type, is an important part of the life and work of each individual. In addition, it is important for further growth and development for both the individual and the entire organization.During communication, there are often errors in the transfer of information, so it is necessary to work continuously to improve the quality of information. Also, important differences in communication can be noted when there is a change from regular to emergency situations. Responsible and empowered persons must ensure that communication is at a satisfactory level in order to eliminate the consequences, reduce material damage, human casualties and prevent further development of disasters.
DESIGNING AN ESP COURSE FOR THE 21ST CENTURY STUDENTS: THE CLASH OF THE DIGITAL IMMIGRANTS AND NATIVES
Authors: Kirovska-Simjanoska Daniela
Published: June 2021

How do teachers design an ESP syllabus for the students born and raised with technology? Are we prepared for the students arriving at universities with new ways of thinking and consuming information? Is it time for us to rethink and re-examine the way we create our syllabi? The ESP course for Computer Science students taught at the South East European University (SEEU) in Macedonia is designed according to students’ needs and it includes a number of 21st century skills. 21st Century skills are 12 abilities that today’s students need to succeed in their careers during the Information Age. Upon successful completion of the course, students are expected to be able to use the language that they will acquire and practice throughout the course, integrating the four main language elements and skills towards fulfilling their academic needs as well as their occupational needs for their future careers. The idea of this paper is to show whether the author, being a digital immigrant herself, has succeed in creating an engaging and motivating syllabus for the digital natives. It will also cover some aspects of the online teaching during the COVID-19 pandemic. As it will be demonstrated in the paper, letting students have a say in the design of the syllabus proved to be beneficial for both parties.
TRASH TO TREASURE: INTEGRATING ENVIRONMENTAL AWARENESS INTO UNIVERSITY CURRICULUM
Authors: Vasileva Polina , Golubev Vadim Yuryevitch , Ibragimov Ildar , Rubtsova Svetlana
Published: June 2021

Over the last decade, educators around the world have paid increasing attention to raising public awareness of the need to make concerted efforts to provide a sustainable future for this planet. Many scientists and eco-activists have done a lot to develop public environmental consciousness using different educational tools. This paper discusses integrating environmental awareness into academic curriculum. It analyses the introduction of an environmental component to the English for the Media course offered at St Petersburg University. The experimental study was conducted for three semesters: in the spring semester of 2019 (February - May 2019), the fall semester of the same year (September - December 2019) and the spring semester of 2020 (February - May 2020). It involved 65 first - and second-year journalism students. Media professionals are responsible for changing the way people look at the environment. Project-based learning helps students to expand their environmental repertoires such as shaping public perception of ‘green consumerism’ as a fashionable trend. The growing awareness of environmental issues requires shaping consumer's mindfulness about obliteration and depletion of natural resources through irresponsible activities. The trash-to-treasure and eco-comics projects are lightweight, exciting and effective tools of raising environmental awareness in future media practitioners and enhancing their scientific writing skills. Using these skills journalists can make their environmental messages accessible to a broader public.
ФИЛОЗОФИЈА У ЗАТВОРСКИМ ЗАЈЕДНИЦАМА
Authors: Павићевић Оливера , Илијић Љепосава , Степановић Ивана
Published: June 2021

Changes in penal policy which is a part of the neoliberal paradigm have political significance and social consequences within and outside prison communities. The prison population is growing despite the fall and stagnation of the crime rate in developed countries which creates a paradox mirrored in the politics of the neoliberal regulation. It is connected to the “new penology” which unlike the “old” penology sees the prison community as a statistical collective which entails a particular risk for the realization of the set governing goals. Since there is a shift from “hard” to “soft” power within prison communities, this paper discusses the disciplinary effects of this process. It showcases the effects of various projects which have introduced philosophy into prison environments as a way to encourage individual identity growth and inspire the return of practices of rehabilitation as a psychological, moral and social recovery of an individual.
RELEVANCE OF TRANSLATION IN ESP TEACHING METHODOLOGY
Authors: Stojković Nadežda
Published: June 2021

This paper offers an observation and discussion on the relevance and scope of presence of translation within English for Specific Purposes courses in academic settings of the Faculty of Electronic Engineering and Faculty of Medicine, University of Niš. There is concern with methodological issues of translation skills regarding domain terminology. This subsumes translation methodology, finding precise target language equivalents, as well as determining whether to translate a text, respecting the syntax of the target language, or to paraphrase it with the primary aim to most precisely convey information contained in the original. The main argument and the issue of the survey conducted with the students of both faculties is direct correlation between translation, or absence of it for that matter, and the cognition of the domain content taught. Then, there is an emphasis on a wider social context that implies inducing in students the awareness of the responsibility they as future professionals and experts in their field have towards their own mother tongue in the dissemination of content knowledge. It is common in the Serbian scientific and professional environment that the translation of scientific texts in English is done by domain experts without consulting linguists, philologists of Serbian language. The consequence is mere (and often incorrect) transliteration of English scientific terminology, and ultimately uncurbed influx of foreign terminology. Yet another argument on the relevance of the previous one is that translation enhances soft transversal skills such as thoughtfulness and critical thinking which among others benefit comprehension of the domain knowledge, as it has been noted that professors, and then students use the English terminology while speaking Serbian, where the latter group do not fully understand the content presented in such scientific ‘newspeak’. The paper presents concrete teaching practice which has for its goal inducing the students with cautiousness when choosing professional terminology in either language.
THE READINESS OF TEACHERS FOR IMPLEMENTING INFORMATION AND COMMUNICATION TECHNOLOGY IN SERBIAN HIGHER EDUCATION INSTITUTIONS
Authors: Шћепановић Данијела , Кораћ Исидора , Лазаревић Бојан
Published: June 2021

Recent advancements of Information and Communication Technology (ICT) and the increased use of ICT related services in the field of online learning offer a range of possibilities, but also pose a challenge for administration in the institutions of higher education. A plethora of official documents dealing with the analysis of how ICT is applied in teaching practice indicate the existing gap in teachers’ digital competencies for its implementation. The paper discusses teachers’ perceptions of various aspects related to the use ICT in teaching at higher education institutions, as well as their needs for professional development in this area. The study included 211 teachers employed in higher education institutions within the Universities of Belgrade, Novi Sad, Kragujevac, Novi Pazar, and Nis. Considering the purpose of this research, the authors designed a measuring instrument comprised of open and closed-ended questions. The study results indicate that teachers recognize the need for integrating ICT in instruction, while their perception of the level of access to ICT learning resources varies depending on the given technology or ICT related services. It is identified that the practical integration of ICT in the classroom still remains at an intermediate or relatively low level. With regard to teacher perception of the intensity of utilizing different software applications in direct instruction, the overall results demonstrate that basic business/productivity application packages such as MS Office are the predominant form of software used in the classroom, followed by Learning Management Systems (LMS). Finally, it is worth noting that teachers’ perception of available professional development opportunities is considerably low, but coupled with a relatively high personal interest in participating in professional development activities.
ASSESSMENT OF THE NEGATIVE IMPACT ON THE ENVIRONMENT OF ALTERNATIVE ENERGY SOURCES
Authors:   Palina Pavlovna Protsenko Amur State University, PROTSENKO PALINA PAVLOVNA , NIKOLAEVA TATIANA ANDREEVNA ,   TATIANA ANDREEVNA NIKOLAEVA Amur State University
Published: June 2021

In the presented study, the task was set to analyze the environmental problems that arise during the production of electrical energy from alternative energy sources.
ASSESSMENT OF SIGNS OF ACCOUNTING FALSIFICATION REPORTING OF CONSTRUCTION ORGANIZATIONS USING FINANCIAL SIMULATION
Authors:   EKATERINA ANDREEVNA PETRENKO Amur State University, PETRENKO EKATERINA ANDREEVNA , YAKIMOVA VILENA ANATOLYEVNA ,   VILENA ANATOLYEVNA YAKIMOVA  Amur State University
Published: June 2021

In this article, a modern methodological toolkit for identifying the facts of falsification of an organization's financial statements was reviewed and tested. A comparative assessment of the results of factor modeling on the example of construction organizations is presented, the main advantages and disadvantages of the factor modeling method are revealed.
Collaboration for chemistry communication: Insights from a research-practice partnership
Authors: Kunz Kollmann Elizabeth , Beyer Marta , Howell Emily , Anderson Allison , Weitzman Owen , Bequette Marjorie , Haupt Gretchen , Velazquez Hever , Yang Shiyu , Scheufele Dietram
Published: June 2021

As several recent National Academies of Sciences reports have highlighted, greater science communication research is needed on 1) communicating chemistry, and 2) building research-practice partnerships to advance communication across science issues. Here we report our insights in both areas, gathered from a multi-year collaboration to advance our understanding of how to communicate about chemistry with the public. Researchers and practitioners from science museums across the U.S. partnered with academic social scientists in science communication to develop and conduct multi-strand data collections on chemistry communication and informal education. Our focus was on increasing interest in, the perceived relevance of, and self-efficacy concerning chemistry through hands-on activities and connecting chemistry to broader themes concerning everyday life and societal impacts. We outline challenges and benefits of the project that future collaborations can gain from and illustrate how our strands of work complemented each other to create a more complete picture of public perceptions of chemistry.
Bienestar y autoestima: un estudio comparativo en estudiantes de los colegios de la Policía Nacional
Authors:   Policía Nacional de Colombia, Bogotá, Colombia, López Muñoz Liliana , Fernández Martínez Yina Patricia ,   Policía Nacional de Colombia, Bogotá, Colombia, Torres Merchán Ana María ,   Universidad EAFIT, Medellín, Colombia, Cardona Jaramillo Fabiana ,   Universidad EAFIT, Medellín, Colombia, Lemos Hoyos Mariantonia ,   Universidad EAFIT, Medellín, Colombia
Published: June 2021

Este estudio evaluó la eficacia de una intervención virtual enfocada en el mejoramiento de la autoestima y el bienestar en adolescentes de los colegios de la Policía Nacional mediante la investigación cuasi experimental con 194 estudiantes (Rango de edad: 12-17 años, M = 13.76 años, D.E. = 1.089; 58.4 % mujeres) asignados aleatoriamente por grupos. La intervención consistió en cuatro encuentros sincrónicos, un taller para padres, una asesoría individual y un cuadernillo de actividades asincrónicas, basado en la teoría de acción razonada/planeada y el modelo ecológico de Bronfenbrenner. Los participantes respondieron el Cuestionario para la Evaluación de Problemas en Adolescentes Q-PAD antes y después de la intervención. Los resultados del análisis, con 135 estudiantes que finalizaron la intervención (70 caso y 65 control), mostraron que los estudiantes intervenidos presentaron menor incertidumbre frente al futuro y niveles de depresión mínimos en comparación con el grupo control. La autoestima y el bienestar evidenciaron un aumento, aunque no fue estadísticamente significativo respecto al control. Se discuten las lecciones aprendidas y se dan recomendaciones para mejorar la intervención. Se concluye que la intervención es adecuada para reducir la incertidumbre y depresión en adolescentes, lo que podría incidir posteriormente en mejorar la autoestima y el bienestar.
El delito leve de hurto en la ciudad de Barcelona. Perfil del delincuente y comparación en función del tipo de hurto
Authors:   Universidad de Barcelona, Barcelona, España, Roca Mercadé Cristina , Trespaderne Dedeu Ariadna ,   Universidad de Barcelona, Barcelona, España
Published: June 2021

La presente investigación tiene como objetivo analizar el perfil de los delincuentes que cometen delitos leves de hurto en la ciudad de Barcelona, en función del hurto cometido, ya sea comercial o personal. La muestra fue extraída de diligencias policiales de la Guardia Urbana de Barcelona. Se han estudiado 56 delitos de hurto leve, con un total de 71 delincuentes. Los resultados revelan que los delincuentes comúnmente son hombres, adultos jóvenes, extranjeros, que actúan de manera individual (o grupal en el caso de los más jóvenes), con domicilio en Barcelona y antecedentes penales de reincidencia en el hurto, además de versatilidad criminal para cometer también otro tipo de delitos. Se hallan diferencias en función de si el hurto es comercial o personal. Se concluye que los hurtadores comerciales son más planificados y premeditados, mientras que los personales son más oportunistas y dependen en mayor medida del azar. Finalmente, este estudio facilita la toma de decisiones en el trabajo policial para la prevención del delito, considerando las características y el comportamiento de los delincuentes según el tipo de hurto.
Representación energética macroscópica y simulación de una máquina síncrona de imanes permanentes
Authors: Correa-Casas Juan Diego , Rayo-Villamizar Diego Steven , Solano-Martínez Javier Enrique
Published: June 2021

Este artículo presenta un modelo de simulación de la máquina síncrona de imanes permanentes (MSIP) y su sistema de control de velocidad utilizando el formalismo de la Representación Energética Macroscópica (REM). Esta descripción gráfica permite realizar un esquema de control basado en la inversión del modelo de la máquina. Los modelos se validan mediante comparación con resultados presentados en la literatura. Para mostrar la utilidad del modelo presentado, se presentan resultados de simulación de la máquina ante diferentes condiciones de operación y referencias de control.
Computational analysis of hybrid heating of a heterogeneous core-shell configuration for improving temperature uniformity
Authors: Amaya Iván , Bastidas-Rodríguez Juan David , Correa-Cely Carlos Rodrigo
Published: June 2021

Throughout this study, we propose using hybrid heating (microwaves – thermal radiation) on a heterogeneous structure. Our goal is to improve the effectivity of its thermal treatment. We analyze a core-shell assembly with different thermal and electrical properties. A solid sphere makes up the core of the arrangement. Such a core is surrounded by three layers of different materials. Because of the properties of the original system, we propose modifying the core so that it absorbs microwaves. The layers are all homogeneous and microwave transparent. The first two exhibit a low thermal conductivity, while the outermost one is a good thermal conductor. We also propose adding a thin layer of susceptor between the first two layers, striving to alleviate the low thermal conduction problem. Furthermore, the dielectric loss constant of this new layer is temperature-dependent. We assume that the composed sphere hangs within the electromagnetic cavity and continuously rotates, so it homogeneously receives microwaves and thermal radiation (from an electrical resistance). Thus, the thermal model is given by a set of time-dependent partial differential equations. Transient temperature profiles are analyzed under different experimental scenarios. There is a clear advantage of using the proposed hybrid heating in this particular case.
Sistema de recomendación de programas universitarios para estudiantes de educación media basado en Deep Learning
Authors: Orozco-Cacique Johanna Alexandra , Moreno-Barbosa Andres Darío
Published: June 2021

Los estudiantes que van a culminar la educación media y se enfrentan a la selección de programas académicos, usualmente usan buscadores web, información de programas y asesorías o pruebas vocacionales. Sin embargo, estas alternativas tienen limitaciones, porque no tienen en cuenta las características sociodemográficas del estudiante ni su desempeño académico o no pueden guiar adecuadamente a todos los estudiantes. Esta propuesta apoya la toma de decisiones de este grupo poblacional con un Sistema de Recomendación que produce recomendaciones basadas en variables sociodemográficas y datos académicos históricos de estudiantes de pregrado.  Además, se compara el desempeño de un modelo de Filtrado Colaborativo clásico y Deep Learning.
Personalized dose reduction based on serum TNF-inhibitors concentration do not lead to changes in disease activity in chronic arthritis: A randomized controlled trial
Authors: Pfeiffer-Jensen Mogens , Liao Donghua , Tarp Ulrik , Deleuran Bent , Stengaard-Pedersen Christian , Venborg Jacob , Brock Birgitte , Brock Christina
Published: June 2021

OBJECTIVES: We hypothesized that Therapeutic Drug Monitoring (TDM)
decreased drug consumption or accelerated switch of biologics in chronic
arthritis patients undergoing TNF-alpha inhibiting (TNFi)-therapy.
Primary outcome was dose reduction, secondary outcomes included clinical
scores DAS28-CRP or ASDAS-CRP, self-reported outcome and experienced
adverse events. METHODS: 48-week prospective, randomized open-label
trial investigating TDM in participants (n=239) treated with infliximab
(IFX), etanercept (ETN) or adalimumab (ADA), receiving standard of care
or standard of care plus TDM, the latter based on serum-trough
concentration measurements of IFX, ETN and ADA. Independent of clinical
status, adults treated for their rheumatoid arthritis (41%), psoriatic
arthritis (20%), or spondylarthritis (39%), were included in a
tertiary outpatient clinic. Serum TNFi trough-values were determined at
inclusion and every 16 weeks and used proactively in the TDM-group to
evaluate whether participants were within the therapeutic window or not,
consequently leading to maintained TNFi-therapy, dose-reduction, or
switch to other biologics. RESULTS: In comparison to standard of care,
TDM reduced doses for IFX (- 12% [CI: -20; -3] p=0.001); ETN (-15
% [-29; 1]; p=0.01) and prolonged the inter-dosing interval in ETN
(+ 235 %;[38;432] p=0.02) and ADA (+ 28%;[6; 51] p = 0.04) and
accelerated switch of biologics (χ2= 6.03, p=0.01). No group-differences
were shown in clinical assessment CRP, DAS28-CRP or ASDAS-CRP, nor in
self-reported outcome or experienced adverse events, indicating
sustained disease control. • CONCLUSIONS – TDM improved clinical
decision making and caused earlier and targeted dose-reduction and
accelerated switch of biologics, thereby preventing over- and under
medication.
Odontogenic Myxoma of the Anterior Mandible: Case Report of a Rare Entity and Review of the Literature
Authors: Sohrabi Maryam , Dastgir Ramtin
Published: June 2021

We report a case of a 38-year-old female patient with odontogenic myxoma
who was referred to us with chief complaint of a persistent painful
lesion and teeth mobility in the anterior region of the mandible which
had underwent a faulty treatment plan in an outside clinic.
Imaging Immunological Processes from Blood to Brain in ALS
Authors: Amor Sandra , Nutma Erik , Marzin Manuel , Puentes Fabiola
Published: June 2021

Neuropathology studies of amyotrophic lateral sclerosis (ALS) and animal
models of ALS reveal a strong association between aberrant protein
accumulation and motor neuron damage and activated microglia and
astrocytes, the resident CNS innate immune cells. While the role of
neuroinflammation in the pathology of ALS is unclear imaging studies
support the idea that innate immune activation occurs early disease in
both humans and rodent models of ALS. In addition to innate immunity,
emerging studies also reveal the presence of peripheral monocytes,
macrophages, and lymphocytes in the CNS as well as at the neuromuscular
junction. To better understand the association of neuroinflammation
(innate and adaptive) with disease progression paraclinical studies
including the use of biomarkers and imaging modalities allow monitoring
of immune parameters in the disease process. Such approaches are
important for patient stratification, selection, and inclusion in
clinical trials, as well as to provide readouts of response to therapy.
Here, we discuss the different imaging modalities e.g., MRI, MRS, PET as
well as other approaches including biomarkers of inflammation in ALS,
aid the understanding of the underlying immune mechanisms associated
with motor neuron degeneration in ALS.
The platelet aIIbβIII integrin has no role in thrombosis in myeloproliferative neoplasm
Authors: Schutgens Roger , Urbanus Rolf
Published: June 2021

We present a patient with congenital Glanzmann Thrombasthenia, who
developed recurrent venous thrombosis. Over time, she developed the
clinical picture of a myeloproliferative neoplasm, being JAK2 positive.
This case clearly indicates that the platelet aIIbβIII integrin (lacking
in Glanzmann thrombasthenia) does not have a role in thrombosis in MPN
On Approximation by Gupta type general family of Operators
Authors: Singh Karunesh
Published: June 2021

In this paper, we study Gupta type family of positive linear operators,
which have a wide range of many well known linear positive operators
e.g. Phillips, Baskakov-Durrmeyer, Baskakov-Sz\’{a}sz,
Sz\’{a}sz-Beta, Lupa\c{s}-Beta,
Lupa\c{s}-Sz\’{a}sz, genuine
Bernstein-Durrmeyer, Link,
P\u{a}lt\u{a}nea,
Mihe\c{s}an-Durrmeyer, link Bernstein-Durrmeyer etc. We
first establish direct results in terms of usual modulus of continuity
having order 2 and Ditzian-Totik modulus of smoothness and then study
quantitative Voronovkaya theorem for the weighted spaces of functions.
Further, we establish Gr\“{u}ss-Voronovskaja type
approximation theorem and also derive
Gr\”{u}ss-Voronovskaja type asymptotic result in
quantitative form.
Research on The Frame of Reference with The Downward Displacement of The Posterior Leaflet and Anterior Leaflet of Tricuspid Valve in Children by Ultrasound
Authors: Yu Jun-jian , Liu Kang , Tian Rong-cheng , Zhong Xuehong , Li Bei
Published: June 2021

To investigate the frame of reference with the downward displacement of
the posterior leaflet and anterior leaflet of tricuspid valve in
children by ultrasound.The downward degree of anterior and posterior
tricuspid valve was evaluated with tricuspid annulus and coronary sinus
as reference structures under ultrasound, and the position of tricuspid
regurgitation orifice was shown by color ultrasound. Color Doppler flow
imaging showed that the position of tricuspid regurgitation orifice
moved down obviously in all 42 children. One case showed 2.2cm from the
root of the anterior valve to the tricuspid annulus in the two-chamber
and four-chamber view of the apical right heart. Color Doppler can show
that the position and direction of tricuspid regurgitation orifice are
obviously deviated to the anterolateral side. The obvious deviation of
the tricuspid regurgitation orifice to the anterolateral direction may
be an ultrasonic sign for diagnosing the downward displacement of the
anterior tricuspid valve in children.
Histopathology of Chironomus riparius (Diptera, Chironomidae) exposed to metal oxide nanoparticles
Authors: Stojanovic Jelena , Milosevic Djuradj , Vitorovic Jelena , Savic-Zdravkovic Dimitrija , Stankovic Nikola , Stankovic Jelena , Vasiljevic Perica
Published: June 2021

As the production of metal-based nanomaterials increases, it is inevitable that nano-scale products and byproducts will enter the aquatic environment. In terms of global production, the most abundant nano-oxides are TiO2, CeO2 and Fe3O4 nanoparticles. Chironomus riparius is commonly used for ecotoxicological assessment and defining its histopathological biomarkers that showcase the toxic effect of tested nanoparticles should lead to a better understanding of the consequences of nanomaterial accumulation in aquatic ecosystems. In this study, a histological description of the digestive and excretory systems as well as the fat body structure of C. riparius larvae is provided. In addition, potential histological biomarkers of nano-oxide toxicity were determined based on the obtained histopathological alterations in organs. Vacuolization was observed in epithelial cells of midgut region I that were treated with nano-Fe3O4 as well as in Malpighian tubules treated with nano-Fe3O4 and nano-CeO2. Larvae exposed to nano-TiO2 showed alterations in the fat body and midgut region II tissue architecture. Additionally, shortening of the intestinal brush border was determined in groups exposed to nano-Fe3O4. These results reveal the high sensitivity of these organs, which can be used as biomarkers in histopathological assessment and therefore lead to further improvement of existing methodology in ecotoxicological studies.
Lessons Learned: Challenges When Conducting Interview-Based Research in Auditing and Methods of Coping
Authors: Dodgson Mary Kate , Trotman Andrew J.
Published: June 2021

Interview-based research is growing in prominence in auditing, yet many researchers are self-trained in this method, leading the novice interview researcher to encounter a number of roadblocks along the way. The overarching goal of our study is to add to the methodological resources available on the interview method by providing a compilation of challenges that novice interview researchers have experienced, along with suggested methods to cope with these challenges (i.e., how to overcome these challenges, what to do differently, and advice on navigating the interview method). With this new perspective, our paper serves as a resource to prospective interview-based researchers so they can enter the field better informed about possible roadblocks they might encounter along the way and methods to cope with these challenges. In turn, we hope to contribute to the production of more insightful and efficient interview-based research.
Information Processing Costs and Firms' Investment Efficiency: An Examination of Channels of the XBRL Effect
Authors: Feng Cecilia (Qian) , Kim Chansog (Francis)
Published: June 2021

We examine the channels through which a reduction in information processing costs improves firm-level investment efficiency. We do so by exploiting the SEC's eXtensible Business Reporting Language (XBRL) mandate. We provide empirical evidence suggesting potential channels. Specifically, we find that, while the use of standardized official elements facilitates investment efficiency, the use of customized extension elements hinders it. In addition, we show that firms with Big 4 auditors experience less improvement in investment efficiency. We also investigate ex post investment performance and find that firms' return on assets and Tobin's q increase following XBRL adoption, suggesting improvements in the effectiveness of investments. Furthermore, we extend this line of research to investments in human capital. Notably, we show that labor investment efficiency is significantly improved in the post-XBRL era. This finding adds another dimension to the growing knowledge about the impact of accounting information on firm-level investment decisions.

JEL Classifications: G30; M40; M41; M48.
In vitro Streptococcus mutans adhesion and biofilm formation on different esthetic orthodontic archwires
Authors: Oliveira Deise C. , Thomson Joshua J. , Alhabeil Jamal A. , Toma Jonathan M. , Plecha Sarah C. , Pacheco Rafael R. , Cuevas-Suárez Carlos E. , Piva Evandro , Lund Rafael Guerra
Published: June 2021

Objectives

To evaluate the ability of different esthetic archwires to retain oral biofilms in vitro.

Materials and Methods

Seven different brands of coated orthodontic archwires were tested: two epoxy coated, two polytetrafluoroethylene coated, two rhodium coated, and one silver plus polymer coated. Conventional uncoated metallic archwires were used as controls. Streptococus mutans adherence to archwires was quantified by colony count following 24 hours of biolfilm growth, and total wire-associated biofilm was measured using a crystal violet staining assay. For both tests, two conditions were used: 0% sucrose and 3% sucrose. For statistical analysis, P < .05 was considered as statistically significant.

Results

For S. mutans colony forming units per biofilm, there were no statistically significant differences among the various archwires (P = .795 for 0% sucrose; P = .905 for 3% sucrose). Regarding total biofilm formed on archwires in the 3% sucrose condition, there were statistically significant differences in crystal violet staining only for the comparison between Niti Micro Dental White and Copper Ni-Ti wires (P < .05).

Conclusions

The clinical use of esthetic-coated orthodontic wires may be considered to have similar risks as uncoated archwires for biofilm retention.
The Ability of Dental Practitioners to Light-Cure Simulated Restorations
Authors: Kojic DD , El-Mowafy O , Price R , El-Badrawy W
Published: June 2021

Objectives:

To determine the ability of dental professionals to deliver a radiant exposure of at least six J/cm2 in 10 seconds to simulated restorations.

Methods and Materials:

The study initially examined 113 light-emitting-diode (LED) light polymerization units (LPUs) used in dental offices to determine if they could deliver at least 6 J/cm2 radiant exposure (RE) in 10s. This assessment was completed by using a laboratory-grade light measuring device (checkMARC, BlueLight Analytics, Halifax, NS, Canada). The participating dental professionals whose LPUs could deliver 6 J/cm2 then used their own LPU to light-cure simulated anterior and posterior restorations in the MARC Patient Simulator (BlueLight Analytics). They then received specific instructions and were retested using the same LPUs. Data were statistically analyzed with a series of one-way analysis of variance (ANOVA), two-way ANOVA, paired-samples t-tests, Fisher post hoc multiple comparison tests, and McNemar tests with a preset alpha of 0.05 (SPSS Inc).

Results:

Ten (8.8%) LPUs could not deliver the required RE to the checkMARC in 10s and were eliminated from the study. For the anterior restoration, most dental practitioners (87.3%) could deliver at least 6 J/cm2 before instructions. After receiving additional light-curing instructions, only two (1.9%) participants were unable to deliver 6 J/cm2 to the anterior location. At the posterior location, only 55.3% (57) participants could deliver at least 6 J/cm2 before the instructions. After receiving these instructions, an additional 32 participants delivered at least 6 J/cm2. Overall, after receiving instructions on how to use the LPU correctly, the participants improved the amount of RE they delivered to anterior and posterior restorations by 22.5% and 30%, respectively.

Conclusion:

This study revealed that at the baseline, 44.7% of participating dental professionals failed to deliver 6 J/cm2 in 10s to the posterior simulated restoration when using their own LPU.
Problems of innovation-oriented development of Russia at the present stage
Authors: Garnov Andrey P. , Garnova Victoria Yu. , Zakharova Elena V. , Prodanova Natalia A. , Rybina Galina A. , Shevchenko Olga P.
Published: June 2021

The subject of the study is the features of such a socio-economic phenomenon as self-employment in the context of digitalization. It is revealed that the rapid development of digitalization has led to the spread of such atypical forms of employment as freelancing. Also, a comparison of different approaches to labor rationing was made: the classical approach to conducting photos of the working day and timekeeping and the modern digitalized approach, their strengths and weaknesses were considered. The possible foreseeable future of labor rationing and the ways of its development and integration of such technology as artificial intelligence are analyzed. The authors consider the possibility of creating an automated program for taking photos of the working day and timekeeping, the use of which would require the presence of a specialist only at the very beginning, when setting up a program for viewing video recordings and identifying individual labor operations.
Estilo Patrimônio: sobre preservação, arquitetura e cenarização | Heritage style: about preservation, architecture and scenarization
Authors: Dias Diego Nogueira
Published: June 2021

Na construção de referenciais identitários nacionais, alguns órgãos foram criados e mobilizados na consolidação do ideário de nação almejado pelas políticas públicas brasileiras da primeira metade do século vinte. Este artigo se debruça sobre a atuação do Instituto do Patrimônio Histórico e Artístico Nacional na cidade de São João del-Rei, Minas Gerais, buscando compreender sua ação no fortalecimento de certo imaginário arquitetônico. Entendendo, pois, a prevalência do gosto pessoal dos arquitetos desse órgão sobre a arquitetura dos núcleos a serem preservados, esta pesquisa também visa entender os atravessamentos ideológicos na desvalorização da arquitetura eclética, alvo maior na transformação dos núcleos setecentistas após seu tombamento federal. Nas intervenções em São João del-Rei as platibandas eram as maiores inimigas dos agentes do Instituto do Patrimônio, e o beiral, endeusado, significava o “retorno ao estado original” da edificação ou a consolidação de uma feição idealizada pelos modernistas. Assim se estabeleceu o “estilo patrimônio”: primeiro com modificações nas edificações ecléticas pré-existentes, em prol de dar-lhes o aspecto “colonioso”; depois adotando as características da arquitetura residencial setecentista como pré-requisito para novas obras e intervenções no núcleo tombado. A partir do levantamento das edificações analisadas nos arquivos do Instituto do Patrimônio, o cruzamento dos dados possibilitou traçar o panorama das modificações realizadas na criação da “cidade-cenário” atualmente existente. Os critérios, empregados até hoje, além deconfigurar um perfil urbano excludente e sem pluralidade, ocasiona a perda do fazer arquitetônico contemporâneo nessa busca equivocada pela preservação.
Tartui felhívás az egészséges életmódértKözös fellépés az egészséges életmód előmozdításáért
Authors: Veress Réka
Published: June 2021

2017. szeptember 23-án, az Európai Sporthét nyitónapján fontos szakpolitikai kezdeményezés született az Európai Unióban, amelynek célja az egészséges életmód előmozdítása. Az észt EU elnökség alatt Tartuban 3 uniós biztos aláírta az úgynevezett Tartui Felhívást az Egészséges Életmódért (Tartu Call for a Healthy Lifestyle). Navracsics Tibor, oktatásért, kultúráért, ifjúságért és sportért, Vytenis Andriukaitis, egészségügyért és élelmiszerbiztonságért és Phil Hogan, mezőgazdaságért és vidékfejlesztésért felelős uniós biztosok...