bluuebunny/crossref_metadata_2025 huggingface dataset:
Platelet/lymphocyte, neutrophil/lymphocyte, and lymphocyte/monocyte ratios as biomarkers for rheumatoid arthritis: correlation with disease activity
Authors: Elsayed Sahar A. , Basily Shereen M. , Esmail Mohamed A. , Mounir Ola
Published: August 2023

Background

Assessment of disease activity in rheumatoid arthritis (RA) patients is essential for the adjustment of therapy. Inflammatory changes in lymphocytes, neutrophils, monocytes, and platelets supported the use of neutrophil/lymphocyte ratio (NLR), lymphocyte/monocyte ratio (LMR), and platelet/lymphocyte ratio (PLR) as markers of inflammation, we aimed to explore the clinical significance of PLR, NLR, and LMR in RA patients.

Results

The study included 120 RA patients and 50 healthy matched controls. Clinical and laboratory data of the patients were assessed. Disease activity was measured using disease activity score (DAS28). Complete blood count (CBC) with differential count was used for the calculation of NLR, PLR, and LMR. Patients had significantly high NLR, and PLR (p < 0.001) and significantly low LMR (p < 0.001) when compared with the control group. Also, there were significant differences in the three ratios between patients in activity and those in remission (p < 0.001). Similarly, there were significant differences in all three ratios between patients with different degrees of disease activity. DAS28 score was positively correlated with NLR, PLR (r = 0.666, p < 0.001, r = 0.586, p < 0.001) and negatively correlated with LMR (r = 0.761, p < 0.001). Receiver operating characteristic (ROC) curve analysis revealed that NLR had the highest sensitivity (86.9%) for RA disease activity, followed by PLR (85.9%) then LMR (76.2%), and regarding the specificity, NLR had high specificity (81%) followed by LMR (78%) then PLR (67%).

Conclusions

Given that NLR, PLR, and LMR were significantly different in patients when compared with the controls, also on comparing different degrees of disease activity and the three ratios were significantly correlated with DAS28 score, in addition to their good sensitivity and specificity for detection of RA disease activity, all this imply that they may be easy, reliable, cost-effective, and time-saving biomarkers when added to DAS28 score for the assessment of RA disease activity.
Open surgical treatment for aortic arch and coronary artery aneurysms associated with immunoglobulin G4-related disease: a case report
Authors: Yokoyama Toshiki , Suzuki Ryo , Kurazumi Hiroshi , Tanaka Akira , Kawano Hiroo , Mikamo Akihito , Ikeda Eiji , Hamano Kimikazu
Published: August 2023

Background

Immunoglobulin G4-related disease (IgG4RD) is a systemic autoimmune disease characterized by a dense lymphoplasmacytic infiltrate containing IgG4-positive plasma cells that can cause aneurysms in various organs and tissues. There have been many reports of IgG4RD aneurysms; however, the surgical procedures adopted remain controversial. Herein, we report a case in which surgical treatment for IgG4-related aneurysms was successful.

Case presentation

An 83-year-old woman with IgG4-related disease developed multiple aneurysms, including thoracic aortic aneurysm (TAA), right coronary artery aneurysm (CAA), abdominal aortic aneurysm, and common iliac artery aneurysm. Enhanced computed tomography (CT) revealed progressive enlargement of the TAA, while positron emission tomography-CT revealed intense 18F-fluorodeoxyglucose uptake around the TAA and CAA, suggesting the presence of adhesive tissue caused by adventitial inflammation around the aneurysms. Open aortic arch replacement with frozen elephant trunk procedure and coronary artery bypass grafting with ligation of the coronary artery were performed to treat the TAA and CAA. No surgical complications occurred. The postoperative CT scan showed no endoleak around the open stent graft and the coronary artery was patent. The patient is being followed up on an outpatient basis after discontinuing steroid therapy.

Conclusions

We report the successful surgical treatment of IgG4-related multiple aneurysms. Our findings reveal that the main site of inflammation in aneurysms of IgG4RD is the adventitia and the frozen elephant trunk procedure is useful for avoiding complications.
Wallenberg syndrome in a patient after pulmonary resection: a case report
Authors: Matsuo Tsubasa , Kimura Daisuke , Tani Kengo , Sasaki Takahiro , Minakawa Masahito
Published: August 2023

Background

Cerebral infarction after pulmonary resection is a minor but critical complication. We report a rare case of postoperative complication of Wallenberg syndrome caused by cerebral infarction in the posterior inferior cerebral artery after the left upper lobectomy.

Case presentation

A 72-year-old man developed cerebral infarction 2 days after a left upper lobectomy for lung cancer. Magnetic resonance imaging indicated right vertebral artery occlusion following an early ischemic area on the right lateral side of the medulla oblongata and cerebellum. Contrast-enhanced computed tomography revealed no thrombus in the left superior pulmonary vein stump. The patient was diagnosed with Wallenberg syndrome, and prompt anticoagulation therapy was initiated. The patient was discharged and transferred to another hospital for rehabilitation on postoperative day 16.

Conclusions

We present a rare case of Wallenberg syndrome occurring in the posterior inferior cerebral artery area due to vertebral artery occlusion after lobectomy. Because cerebral infarction of the posterior circulation has many similar symptoms due to the side effects of anesthetic drugs, careful physical examination is required to determine Wallenberg syndrome.
Tackling antimicrobial resistance by integrating One Health and the Sustainable Development Goals
Authors: Ferdinand Angeline S. , Coppo Mauricio J. C. , Howden Benjamin P. , Browning Glenn F.
Published: August 2023

Antimicrobial resistance (AMR) has been identified as a leading threat to global public health. One Health approaches that integrate sectors across human health, animal health, food production and the environment are essential to both addressing the growing threat of AMR and achieving the Sustainable Development Goals.
Fast 3D simulation of magnetotelluric data in anisotropic media using a rational Krylov method
Authors: Zhou Junjun , Bai Ningbo , Hu Xiangyun , Xiao Tiaojie , Long Zhidan
Published: August 2023

This study introduces a computational method aimed at accelerating multifrequency 3D magnetotelluric (MT) forward modeling in 3D conductivity structures with general anisotropy. The approach combines an edge-based finite-element (FE) method with a rational Krylov subspace method. In this method, the MT source term is expressed as a planar current source, and the frequency-dependent electric field response is the product of a transfer function and a constant vector of the current source. Consequently, the rapid approximate electric field for multifrequency calculations can be obtained by constructing the orthogonal basis of the rational Krylov subspace. By applying this technique, the large sparse matrix resulting from FE discretization can be projected onto a much lower-order matrix, significantly reducing its size to tens or hundreds. Incorporating the direct solver PARDISO to construct the orthogonal basis enables a considerably faster solution compared with the previous FE method. Moreover, the algorithm is implemented using Julia, a high-level programming language known for its readability, maintainability, and extensibility. The validity of the algorithm is demonstrated through a 1D anisotropic model, and two additional 3D models are designed to further evaluate the applicability and effectiveness of our algorithm. Numerical experiments illustrate a notable increase in modeling speed compared with the traditional edge-based FE method.
Randomized Phase II Multicenter Trial of Abiraterone Acetate With or Without Cabazitaxel in the Treatment of Metastatic Castration-Resistant Prostate Cancer
Authors: Slovin Susan F. , Knudsen Karen , Halabi Susan , de Leeuw Renee , Shafi Ayesha , Kang Praneet , Wolf Steven , Luo Bin , Gopalan Anuradha , Curley Tracy , Fleming Mark , Molina Ana , Fernandez Celina , Kelly Kevin
Published: August 2023

Upfront combination therapy in 81 chemotherapy/ARSI-naïve patients with mCRPC was well tolerated with improved PFS.
Integrative Oncology Care of Symptoms of Anxiety and Depression in Adults With Cancer: Society for Integrative Oncology–ASCO Guideline
Authors: Carlson Linda E. , Ismaila Nofisat , Addington Elizabeth L. , Asher Gary N. , Atreya Chloe , Balneaves Lynda G. , Bradt Joke , Fuller-Shavel Nina , Goodman Joseph , Hoffman Caroline J. , Huston Alissa , Mehta Ashwin , Paller Channing J. , Richardson Kimberly , Seely Dugald , Siwik Chelsea J. , Temel Jennifer S. , Rowland Julia H.
Published: August 2023

PURPOSE

To provide evidence-based recommendations to health care providers on integrative approaches to managing anxiety and depression symptoms in adults living with cancer.

METHODS

The Society for Integrative Oncology and ASCO convened an expert panel of integrative oncology, medical oncology, radiation oncology, surgical oncology, palliative oncology, social sciences, mind-body medicine, nursing, methodology, and patient advocacy representatives. The literature search included systematic reviews, meta-analyses, and randomized controlled trials published from 1990 through 2023. Outcomes of interest included anxiety or depression symptoms as measured by validated psychometric tools, and adverse events. Expert panel members used this evidence and informal consensus with the Guidelines into Decision Support methodology to develop evidence-based guideline recommendations.

RESULTS

The literature search identified 110 relevant studies (30 systematic reviews and 80 randomized controlled trials) to inform the evidence base for this guideline.

RECOMMENDATIONS

Recommendations were made for mindfulness-based interventions (MBIs), yoga, relaxation, music therapy, reflexology, and aromatherapy (using inhalation) for treating symptoms of anxiety during active treatment; and MBIs, yoga, acupuncture, tai chi and/or qigong, and reflexology for treating anxiety symptoms after cancer treatment. For depression symptoms, MBIs, yoga, music therapy, relaxation, and reflexology were recommended during treatment, and MBIs, yoga, and tai chi and/or qigong were recommended post-treatment.

DISCUSSION

Issues of patient-health care provider communication, health disparities, comorbid medical conditions, cost implications, guideline implementation, provider training and credentialing, and quality assurance of natural health products are discussed. While several approaches such as MBIs and yoga appear effective, limitations of the evidence base including assessment of risk of bias, nonstandardization of therapies, lack of diversity in study samples, and lack of active control conditions as well as future research directions are discussed. Additional information is available at www.asco.org/survivorship-guidelines .
Post-translational modifications of ATG8 proteins – an emerging mechanism of autophagy control
Authors: Nieto-Torres Jose L. , Zaretski Sviatlana , Liu Tianhui , Adams Peter D. , Hansen Malene
Published: August 2023

Autophagy is a recycling mechanism involved in cellular homeostasis with key implications for health and disease. The conjugation of the ATG8 family proteins, which includes LC3B (also known as MAP1LC3B), to autophagosome membranes, constitutes a hallmark of the canonical autophagy process. After ATG8 proteins are conjugated to the autophagosome membranes via lipidation, they orchestrate a plethora of protein–protein interactions that support key steps of the autophagy process. These include binding to cargo receptors to allow cargo recruitment, association with proteins implicated in autophagosome transport and autophagosome–lysosome fusion. How these diverse and critical protein–protein interactions are regulated is still not well understood. Recent reports have highlighted crucial roles for post-translational modifications of ATG8 proteins in the regulation of ATG8 functions and the autophagy process. This Review summarizes the main post-translational regulatory events discovered to date to influence the autophagy process, mostly described in mammalian cells, including ubiquitylation, acetylation, lipidation and phosphorylation, as well as their known contributions to the autophagy process, physiology and disease.
Prognostic Significance of Sentinel Lymph Node Status in Thick Primary Melanomas (> 4 mm)
Authors: Holmberg Carl-Jacob , Mikiver Rasmus , Isaksson Karolin , Ingvar Christian , Moncrieff Marc , Nielsen Kari , Ny Lars , Lyth Johan , Olofsson Bagge Roger
Published: August 2023

Background

The key prognostic factors for staging patients with primary cutaneous melanoma are Breslow thickness, ulceration, and sentinel lymph node (SLN) status. The multicenter selective lymphadenectomy trial (MSLT-I) verified SLN status as the most important prognostic factor for patients with intermediate-thickness melanoma (Breslow thickness, 1–4 mm). Although most international guidelines recommend SLN biopsy (SLNB) also for patients with thick (> 4 mm, pT4) melanomas, its prognostic role has been questioned. The primary aim of this study was to establish whether SLN status is prognostic in T4 melanoma tumors.

Methods

Data for all patients with a diagnosis of primary invasive cutaneous melanoma of Breslow thickness greater than 1 mm in Sweden between 2007 and 2020 were retrieved from the Swedish Melanoma Registry, a large prospective population-based registry. A multivariable Cox proportional hazard model for melanoma-specific survival (MSS) was constructed based on Breslow thickness stratified for SLN status.

Results

The study enrolled 10,491 patients, 1943 of whom had a Breslow thickness greater than 4 mm (pT4). A positive SLN was found for 34% of these pT4 patients. The 5-year MSS was 71%, and the 10-year MSS was 62%. There was a statistically significant difference in MSS between the patients with a positive SLN and those with a negative SLN (hazard ratio of 2.4 (95% confidence interval CI 1.6–3.5) for stage T4a and 2.0 (95% CI 1.6–2.5) for satage T4b.

Conclusion

Sentinel lymph node status gives important prognostic information also for patients with thick (> 4 mm) melanomas, and the authors thus recommend that clinical guidelines be updated to reflect this.
Coexistence and clinical implications of anemia and depression in the elderly population
Authors: Michalak Sylwia Sulimiera , Sterna Władysław
Published: August 2023

Anemia i depresja są powszechne u osób w podeszłym wieku i stanowią istotny problem medyczny, społeczny i ekonomiczny świata. Obydwa zaburzenia wiążą się z niską jakością życia, wielochorobowością, zwiększonym ryzykiem śmierci. Równoczesne występowanie anemii i depresji zostało potwierdzone w badaniach, ale mechanizmy i konsekwencje kliniczne tej koegzystencji nie zostały dotąd w pełni wyjaśnione. Istnieje szereg powiązań pomiędzy anemią a depresją takich jak wspólne czynniki etiologiczne, niski status socjoekonomiczny pacjentów, niskie wykształcenie oraz mniejsza aktywność fizyczna. W obydwu zaburzeniach stwierdza się te same patologiczne zmiany zależne od wieku (zwłaszcza obecność stanu zapalnego i stresu oksydacyjnego, zmiany degeneracyjne tkanek i narządów), niedobory żelaza czy witamin (B12, kwasu foliowego), zaburzenia hormonalne (zwłaszcza choroby tarczycy, niedobory hormonów płciowych). Zarówno anemia jak i depresja u osób starszych są w niewystarczającym stopniu rozpoznawane i w rezultacie często nie są leczone. Diagnostyka i leczenie obu zaburzeń u osób podeszłym wieku wykazują pewne różnice w stosunku do postępowania w innych grupach wiekowych. Niniejsza praca zawiera przegląd literatury dotyczących wspólnego występowania anemii i depresji u osób w podeszłym wieku oraz rekomendacje postępowania.
Stronger psychological reaction of patients in depression and remission to the first wave of the COVID-19 pandemic in Poland compared to the non-clinical group
Authors: Sokół-Szawłowska Marlena , Mierzejewski Paweł
Published: August 2023

Cel pracy

Celem badania było porównanie subiektywnego stanu psychicznego pacjentów w trwającym epizodzie depresji i w remisji (grupa kliniczna) oraz grupy bez zaburzeń depresyjnych i innych zaburzeń psychicznych w dotychczasowym życiu (grupa niekliniczna).

Metoda

Podczas pierwszego zamknięcia gospodarki w Polsce (12 marca 2020 - 3 maja 2020) za pomocą anonimowej ankiety internetowej oceniliśmy subiektywny stan psychiczny 2284 osób w trzech grupach: z trwającym epizodem depresyjnym- 265 pacjentów i w remisji- 574 pacjentów oraz bez zaburzeń psychicznych (w tym depresji) w wywiadzie-1445 osób.

Wyniki

Wybuch pandemii negatywnie wpłynął na subiektywny stan psychiczny badanych. W grupie z depresją stres o różnym natężeniu odczuwało 98,11% respondentów, w remisji 93,9%, a bez depresji w przeszłości 93,43%. Obniżony nastrój deklarowało 51,32% pacjentów w depresji, 21,60% w remisji i 11,97% bez zaburzeń psychicznych. Codzienne napady lęku występowały u 46,42% pacjentów z depresją, u 20,21% w remisji i 5,88% w grupie nieklinicznej.

Wnioski

Wyniki ankiety wskazują, że pacjenci w trwającym epizodzie depresji i remisji subiektywnie czuli się gorzej niż grupa niekliniczna w pierwszej fali pandemii COVID-19 w Polsce. Jednocześnie osoby wcześniej zdrowe również relacjonowały niecodzienne nasilenie objawów lękowych i depresji. Z tego powodu ważne jest kontynuowanie kompleksowego leczenia depresji oraz zapobieganie zaburzeniom psychicznym w populacji nieklinicznej.
Models of activity in the narratives of people with schizophrenia
Authors: Chądzynska Małgorzata , Kozakiewicz Barbara
Published: August 2023

Cel pracy

Praca prezentuje analizę narracji osób chorych na schizofrenię pod kątem opisów działań. Celem jest poszukiwanie zmian we wzorcach aktywności pod wpływem doświadczenia kryzysu psychotycznego.

Metoda

Porównano trzy fragmenty autonarracji stworzonej przez osoby po doświadczeniu kryzysu psychotycznego dotyczące okresów: przed zachorowaniem, w trakcie choroby oraz w okresach remisji. Materiałem były opowieści 26 osób chorych na schizofrenię na temat ich życia i spostrzegania siebie w wymienionych okresach. Dokonano językowej analizy tekstów wyróżniając wyznaczniki sześciu wybranych wzorców aktywności odnoszących się do poczucia sprawstwa i intencjonalności działań. Zastosowano analizę frekwencyjną i metody wielozmiennowe dla porównywania względnej częstości ich występowania w narracjach.

Wyniki

Opisy aktywności w trakcie choroby są mocniej wysycone wzorcami zewnętrznego umiejscowienia kontroli, nieosobowej kontroli działania, unikania, działań indywidualnych, stanów w porównaniu do okresu remisji, a szczególnie opisów funkcjonowania przed zachorowaniem.

Wnioski

Wyniki analizy narracji osób chorych na schizofrenię wskazują na obniżenie poczucia sprawstwa związane z przeżywaniem stanów chorobowych (subiektywnie definiowanych). Ten deficyt motywacyjny dotyczy także okresów remisji po aktywnej fazie choroby, choć w mniejszym stopniu. Analiza wzorców motywacyjnych ukazuje różnice opisów własnej aktywności wskazujące na występowanie pod wpływem kryzysu psychotycznego różnych sposobów budowania autonarracji i tożsamości narracyjnej w ujęciu retrospektywnym. Zmiany te dotyczą głębokich warstw ukrytych w związku formy narracji z treścią. Wskazują one na inne obrazy siebie (pozycje ja czy głosy autonarracji) jako osoby zdrowej, chorej i w remisji – szczególnie w aspekcie postrzegania własnego sprawstwa.
Grounds for admitting a mentally ill person without their consent to a psychiatric hospital under the application procedure
Authors: Karkowska Dorota , Araszkiewicz Aleksander Stanisław , Nowak Arkadiusz Robert
Published: August 2023

Cel pracy

Celem niniejszego artykułu jest zamieszczenie autorskich komentarzy w zakresie analizy przesłanek przyjęcia osoby chorej do szpitala psychiatrycznego wbrew jej woli na podstawie orzeczenia wydanego przez sąd opiekuńczy w ramach postępowania wszczętego na wniosek podmiotu uprawnionego, a założenia w nim zawarte oparte są o obowiązujące akty normatywne.

Metoda

Wykorzystano metodę analizy aktualnych przepisów prawa medycznego i przepisów prawa zabezpieczenia społecznego. Zebrano, zaprezentowano i rozważono orzecznictwo sądowe, w szczególności Sądu Najwyższego, które stanowią praktyczną wskazówkę w zakresie oceny spełnienia lub niespełnienia przesłanek umieszczenia pacjenta bez zgody w szpitalu psychiatrycznym.

Wyniki

Umieszczenie osoby chorej psychicznie w szpitalu psychiatrycznym bez jej zgody, w sytuacji kiedy osoba ta nie przejawia bezpośredniego zagrożenia dla swojego zdrowia i życia, ani dla zdrowia i życia osób trzecich, ani nie stanowi zagrożenia dla bezpieczeństwa publicznego, jest dość specyficznym ograniczeniem prawa człowieka do wolności, usankcjonowanym przez państwo.

Wnioski

Przepis art. 29 ust.1 u.o.z.p. jest przepisem szczególnym, powinny być wykładany ściśle, bez odwoływania się do zasad wykładni rozszerzającej bądź analogii, a naczelną dyrektywą działania sądów winien być wymóg celowości orzeczenia z punktu widzenia dobra i interesu osoby, której postępowanie dotyczy .
Psychometric properties of the Polish version of the Post-traumatic Stress Disorder Check List according to DSM-5 – PCL-5
Authors: Ogińska-Bulik Janina , Juczyński Zygfryd
Published: August 2023

Cel pracy

Wprowadzone w klasyfikacji DSM-5 zmiany w strukturze objawów PTSD wymagają posługiwania się odpowiednim narzędziem pomiaru. W tym celu skonstruowano i spopularyzowano Listę Zaburzeń po Stresie Traumatycznym (PTSD Checklist – PCL-5). W przedstawionych badaniach dokonano oceny właściwości psychometrycznych polskiej wersji PCL-5. Ponadto, odnosząc się do kontrowersji dotyczących konceptualizacji PTSD w oparciu o własne badania sprawdzono różne wskaźniki dopasowania pięciu modeli struktury PTSD.

Metoda

W anonimowych badaniach uczestniczyły osoby (N = 1035), które doświadczyły różnych zdarzeń traumatycznych. Wszyscy wypełniali PCL-5 oraz inne kwestionariusze służące do oceny trafności PCL-5.

Wyniki

Właściwości psychometryczne polskiej wersji PCL-5 są satysfakcjonujące. W diagnozie różnicowej optymalnym punktem dyskryminacji jest wynik ⩾ 33. Wyniki CFA wykazały, że wszystkie testowane modele PTSD spełniają podstawowe kryteria dopasowania. Model czteroczynnikowy wyjaśniał 58% wariancji, w tym zmiany w pobudzeniu i reaktywności 36%.

Wnioski

Właściwości psychometryczne polskiej wersji PCL-5 są satysfakcjonujące. W diagnozie różnicowej optymalnym punktem dyskryminacji jest wynik ⩾ 33. Wyniki CFA wykazały, że wszystkie testowane modele PTSD spełniają podstawowe kryteria dopasowania. Model czteroczynnikowy wyjaśniał 58% wariancji, w tym zmiany w pobudzeniu i reaktywności 36%.
Operation of Mental Health Centres (CZP) in Poland during the SARS-CoV-2 pandemic
Authors: Lisiecka-Biełanowicz Mira , Molenda Bartłomiej , Biechowska Daria
Published: August 2023

Cel pracy

Opracowanie dotyczy środowiskowego modelu opieki psychiatrycznej realizowanego w ramach programu pilotażowego w Centrach Zdrowia Psychicznego (CZP) w czasie pandemii wywołanej wirusem SARS-CoV-2.
Celem opracowania jest scharakteryzowanie zmian w funkcjonowaniu Centrów Zdrowia Psychicznego (CZP) w Polsce w czasie pandemii.

Metoda

Zmiana koncepcji opieki psychiatrycznej i przejście w kierunku modelu środowiskowego w ramach CZP to m.in. brak konieczności przedstawienia i realizacji ściśle określonych harmonogramów przez świadczeniodawców co pozwala odpowiedzieć na bieżące potrzeby pacjentów oraz umożliwiło dostosowanie warunków i sposobów udzielania świadczeń z zakresu opieki psychiatrycznej w Polsce w czasie pandemii wywołanej wirusem SARS-CoV-2.

Wyniki

Na podstawie doświadczeń z okresu pandemii wywołanej wirusem SARS-CoV-2 przedstawiono rekomendacje dotyczące poprawy organizacji pracy CZP w Polsce.

Wnioski

1. Pilnie potrzebna jest nowa mapa organizacji usług zdrowotnych w zakresie zdrowia psychicznego po okresie szczytu pandemii w Polsce.
2. Dobrze funkcjonująca opieka środowiskowa sprzyja dobremu rozeznaniu potrzeb pacjentów i ich warunków życia, co sprawia, że nawet w sytuacji np. pandemii, nie ma elementu zaskoczenia oraz znane są kanały i sposoby reagowania na zaistniałą sytuację nadzwyczajną (w ramach obszarów związanych m.in. z oceną ryzyka czy zarzadzanie zmianą). W sytuacji epidemii pilotażowe CZP szybko i łatwo dostosowały sposoby reagowania do zmieniających się lub nowych potrzeb/nowych okoliczności.
3. W ramach działań w zakresie reform opieki psychiatrycznej w Polsce na obecnym etapie stosowne wydaje się wykorzystanie wszelkich obserwacji oraz informacji na temat funkcjonowania i organizacji pracy podmiotów które były włączone w czasie pandemii SARS-COVID-19 do programu pilotażowego CZP, aby nieustannie doskonalić funkcjonowanie nowego modelu opieki zdrowia psychicznego, który jest oparty na opiece środowiskowej (CZP).
Research on Anomaly Detection in Vehicular CAN Based on Bi-LSTM
Authors: Kan Xiaopeng , Zhou Zhihong , Yao Lihong , Zuo Yuxin
Published: August 2023

Controller Area Network (CAN) is one of the most widely used in-vehicle networks in modern vehicles. Due to the lack of security mechanisms such as encryption and authentication, CAN is vulnerable to external hackers in the intelligent network environment. In the paper, a lightweight CAN bus anomaly detection model based on the Bi-LSTM model is proposed. The Bi-LSTM model learns ID sequence correlation features to detect anomalies. At the same time, the Attention mechanism is introduced to improve the model’s efficiency. The paper focuses on replay attacks, denial of service attacks and fuzzing attacks. The experimental results show that the anomaly detection model based on Bi-LSTM can detect three attack types quickly and accurately.
An Evaluation Model for Network Security Based on an Optimized Circular Algorithm
Authors: Li Xingfeng
Published: August 2023

With more and more control systems accessing computer networks, the increase in their associated vulnerabilities has led to a decreasing security evaluation of the networks. It is essential to secure computer networks from attacks. To this end, the study constructs a network of computer network security evaluation model based on an optimized circular algorithm. To avoid detecting the model’s parameters falling into the local optimum, the model is first optimized based on the Corsi grey wolf optimization (CGWO) algorithm for the hyperparameters of the Gaussian process (GP). To solve the problem of unbalanced data and the GP not having memory capability, the study proposes an optimized Gaussian Mixture Model-Recurrent neural networks (GMM-RNN) algorithm. Experimental results of attack type recognition accuracy showed that the research CGWO-GP algorithm can jump out of the local optimum, and its average value of accuracy reached 98.99%. The average value of the leakage rate was 0.42%, and the average value of the false alarm rate was 0.11%. The average detection accuracy of the GMM-RNN model for eight attack types was 95.899%. The optimal detection accuracy of this model performance was 96.3948%. The training time of the GMM-RNN model was 67.96 s, and the detection time of the test set was 6.45 s, which greatly optimized the real-time performance. The GMM-RNN model was more effective in predicting the security posture of computer networks, and the prediction value can reach 97.65%. The research model was significantly better than other algorithmic models in the performance and evaluation of computer network security and had certain research values.
Camera Network Topology Mapping Based on the Integration of Network Information and Physical Distribution Under the Background of Communication Security
Authors: Chen Min
Published: August 2023

At present, most cameras use internal networks and use methods such as Traceroute for security protection, which cannot meet the requirements of camera network mapping. Therefore, a camera mapping scheme of network information and physical distribution is proposed. Firstly, the network topology problem of video content information collection was analyzed. This paper uses the mapping relationship between network space and physical space to propose the subnet division conjecture method and complete the preliminary mapping of the network through video data screening. Considering the insufficient coverage of topology mapping, a judgment and inference method based on Bayesian classification technology and network information is proposed, and the results are corrected and evaluated through the test of Jackard coefficient. In the preliminary network topology performance test, two state-of-the-art schemes are selected for experimental comparison. When the number of nodes in the proposed scheme is 5, 25, and 50, the mapping can be completed in the shortest time, and the accuracy reaches 80%. However, the surveying and mapping accuracy of the proposed scheme in the preliminary test is low, and the network information method is used for data screening. In the final surveying and mapping performance test, when the number of nodes is 40, the accuracy of the proposed scheme is 96%, which is better than previously proposed schemes, while the testing delay time is shorter. The technology proposed in the study has the best overall performance. It can effectively solve the problem of intranet surveying and mapping and has important reference value for the security protection of the camera network.
Adaptation of the Ant Colony Algorithm to Avoid Congestion in Wireless Mesh Networks
Authors: Salman Fadhil Mohammed , Lehmoud Ahssan Ahmmed Mohammed , Joda Fanar Ali
Published: August 2023

Wireless mesh networks have recently presented a promising environment for many researchers to develop large-scale wireless communication. Traffic in WMNs often suffers from congestion due to heavy traffic load’s saturation of certain routes. Therefore, this article proposes an efficient approach for congestion awareness and load balancing in WMNs, based on the Ant Colony Optimization (ACO) approach. The proposed approach aims to raise the performance of the WMN by distributing the traffic load between optimal routes and avoiding severe traffic congestion. The proposed approach relies on three basic mechanisms: detection of severe congestion within the ideal paths used for data transmission, creation of ideal secondary paths with updated pheromone values, and distribution of the traffic load (data packet flow) between the primary and secondary ideal paths. According to the results of the NS2 simulator, the suggested approach increased the WMN throughput by 14.8% when compared to the CACO approach and by 37% when employing the WCETT approach. The results also showed that the proposed approach achieved an average end-to-end delay closing of 0.0562, while WCETT and CACO approaches achieved an average end-to-end delay close to 0.1021 and 0.0976, respectively. The results indicated that the proposed approach achieved a lower percentage of dropped packets by 6.97% and 0.99% compared to the WCETT and CACO approaches. Thus, the proposed approach is effective in improving the performance of WMNs.
Indian Men and French “Women”: Fragile Masculinity and Fragile Alliances in Colonial Louisiana, 1699–1741
Authors: Toups Eric
Published: August 2023

abstract: Understandings of gender underpinned every encounter between eighteenth-century Indigenous and colonial leaders. They met each other not just as warriors, traders, or diplomats but also as men . Keeping this in mind, this article examines diplomatic discourse between French colonial officials of Louisiana and Choctaw headmen to understand the underlying tensions in their long-standing alliance. This analysis sheds new light on critical decisions made by both the French and Choctaws about their military strategies and their commitments to defending each other. When one studies several flashpoints in their alliance during the Natchez and Chickasaw Wars, French and Choctaw understandings of masculinity and its entanglements with war, status, and alliance come into focus. Because the Choctaws held the upper hand in the relationship, they typically directed how the often-resentful French performed masculinity; frequently the French did so on Choctaw terms.
Sensor using a photo-acoustic absorption cell with two perpendicular acoustic resonators to analyze multiple molecules
Authors: Bayrakli Ismail , Akman Hatice , Sari Filiz
Published: August 2023

An ultra-high sensitivity multi-molecule sensor based on a photo-acoustic cell with two perpendicular acoustic resonators and a common microphone has been reported. In this work, a 4.5 µm distributed-feedback quantum cascade laser and a 1.5 µm external cavity diode laser (EC-DL) were used as optical excitation sources. Considering the spectral ranges of the lasers used, it is possible to analyze eight molecules (QCL:N2O and CO2, EC-DL: H2O, H2S, NH3, CO, CH4, and C2H2). The N2O molecule was used to evaluate the performance of the photo-acoustic spectroscopy (PAS)-based sensor. A sensitivity of 0.073 V/ppm and a linearity of 0.99 were found by analyzing the PAS signal as a function of N2O concentration at 2237.656cm−1. The long-term performance of the sensor was determined by performing an Allan deviation analysis. A minimum detection limit of 9.8 ppb for 90 s integration time was achieved. The simultaneous multi-trace gas detection capability was verified by measurement of N2O, CO2, and H2O. Depending on the coarse/fine-tuning ranges of the lasers used, the number of molecules analyzed can be further increased. Such a sensor could provide simultaneous diagnosis of many diseases through an analysis of breath air and simultaneous monitoring of the most important greenhouse gases.
Fructose-containing food sources and blood pressure: A systematic review and meta-analysis of controlled feeding trials
Authors: Liu Qi , Chiavaroli Laura , Ayoub-Charette Sabrina , Ahmed Amna , Khan Tauseef A. , Au-Yeung Fei , Lee Danielle , Cheung Annette , Zurbau Andreea , Choo Vivian L. , Mejia Sonia Blanco , de Souza Russell J. , Wolever Thomas M. S. , Leiter Lawrence A. , Kendall Cyril W. C. , Jenkins David J. A. , Sievenpiper John L.
Published: August 2023

Whether food source or energy mediates the effect of fructose-containing sugars on blood pressure (BP) is unclear. We conducted a systematic review and meta-analysis of the effect of different food sources of fructose-containing sugars at different levels of energy control on BP. We searched MEDLINE, Embase and the Cochrane Library through June 2021 for controlled trials ≥7-days. We prespecified 4 trial designs: substitution (energy matched substitution of sugars); addition (excess energy from sugars added); subtraction (excess energy from sugars subtracted); andad libitum(energy from sugars freely replaced). Outcomes were systolic and diastolic BP. Independent reviewers extracted data. GRADE assessed the certainty of evidence. We included 93 reports (147 trial comparisons, N = 5,213) assessing 12 different food sources across 4 energy control levels in adults with and without hypertension or at risk for hypertension. Total fructose-containing sugars had no effect in substitution, subtraction, orad libitumtrials but decreased systolic and diastolic BP in addition trials (P<0.05). There was evidence of interaction/influence by food source: fruit and 100% fruit juice decreased and mixed sources (with sugar-sweetened beverages [SSBs]) increased BP in addition trials and the removal of SSBs (linear dose response gradient) and mixed sources (with SSBs) decreased BP in subtraction trials. The certainty of evidence was generally moderate. Food source and energy control appear to mediate the effect of fructose-containing sugars on BP. The evidence provides a good indication that fruit and 100% fruit juice at low doses (up to or less than the public health threshold of ~10% E) lead to small, but important reductions in BP, while the addition of excess energy of mixed sources (with SSBs) at high doses (up to 23%) leads to moderate increases and their removal or the removal of SSBs alone (up to ~20% E) leads to small, but important decreases in BP in adults with and without hypertension or at risk for hypertension.

Trial registration:Clinicaltrials.gov:NCT02716870.
Late paleozoic climate revealed by coral fossil patterns
Authors: Zhang Weijia , Li Jiaju , Cheng Xue , Yu Hangjie , Cai Shaomin
Published: August 2023

The study of coral fossils with clear growth lines inShiqiantan Formation (310 Ma) in China showed the growth line increments of a single coral growing in this area is related to the sunlight illumination time. Moreover, the daily increment of the growth line caused by calcium carbonate depositions has an unusual bimodal curve. The study of this bimodal curve indicated Shiqiantan had evident four-season changes in the Late Carboniferous period, and the climate at that time was similar to that of modern North China. The present paper updates the oldest existing record of climate analysis materials and provides important information for the study of Late Paleozoic climate, as well as the ancient obliquity of ecliptic.
Excluded and myopic: Social exclusion increases temporal discounting
Authors: Bahrami Radmehr , Borhani Khatereh
Published: August 2023

Social exclusion is a painful yet ubiquitous experience that modulates affect, behavior, and cognition. Decision-making is an essential cognitive ability that some forms of it are altered following social exclusion. However, how intertemporal decision-making is influenced by social exclusion is scarcely studied. Here, using Future Life Alone paradigm we demonstrated that experiencing social exclusion increases temporal discounting. We further tested whether the increased temporal discounting is mediated by either time perception or risk-taking. Our results revealed that although time perception is influenced by social exclusion, neither time perception nor risk-taking mediated the changes in temporal discounting. Our results are providing further evidence corroborating that social exclusion evokes cognitive deconstruction and therefore alters temporal discounting.
Elephant tourism: An analysis and recommendations for public health, safety, and animal welfare
Authors: Warwick Clifford , Pilny Anthony , Steedman Catrina , Grant Rachel
Published: August 2023

Background: Elephants are exploited for public entertainment tourism throughout Asia and Africa. Areas of concern include public health and safety and animal welfare.

Materials and Methods: We examined over 500 scientific publications with respect to our primary objectives, as well as non-peer-reviewed materials relating to other relevant subject matters (e.g., tourism promotional websites and YouTube films) for background purposes, although these additional materials were not included in this review.

Results: We identified at least 12 confirmed or potential zoonotic and other transmissible infections relevant to the elephant tourism sector, and at least 13 areas of animal welfare concern.

Conclusion: Infection and injury risks between humans and captive elephants cannot be safely controlled where close contact experiences are involved, arguably creating an unredeemable and indefensible public health and safety situation. Elephant welfare within some sectors of the close contact interactive tourism industry continues to involve significant mistreatment and abuse. To alleviate key One Health concerns outlined in this study, we recommend several types of regulation, monitoring, and control regarding interactions at the human-captive elephant interface. These include legal bans on the promotion and performance of close contact experiences, combined with strong enforcement protocols; new policies toward discouraging elephant tourism; 24/7 surveillance of captive elephants; and the adoption of independent scientific positive list systems for tourism promoters or providers regarding public observation of free-ranging elephants within national parks and protected areas.

Keywords: animal welfare, elephant tourism, One Health, public health, safety, zoonoses.
A recent update on the use of antimicrobials for animal health in Yogyakarta, Indonesia
Authors: Wijayant Agustina Dwi , Rosetyadew Antasiswa Windraningyas , Pratama Anggi Muhtar , Septana Aria Ika , Setyawan Dwi Cahyo Budi , Fitriana Ida
Published: August 2023

Background and Aim: Animal antimicrobials must be studied to determine if they have the same types, norms of use, and resistance patterns as those used in humans. This study aimed to facilitate the analysis of data on the use of antimicrobials in veterinary medicine and to aid in developing a strategy to prevent the emergence of antimicrobial resistance (AMR) in humans and animals.

Materials and Methods: Data were obtained through a survey of 101 veterinarians working in animal clinics and independent practice in five regencies of Yogyakarta province.

Results: Both of the antibiotics, antiparasitic (78.6%) and, antiseptic and disinfectant (68.0%), and antifungal (31.1%) were the most frequently used types of antimicrobials, while antivirals were the least used (9.7%). The most often treated animals with antimicrobials are pets (37%), followed by large and small livestock (30%), poultry (15%), and exotic animals (14%). Of the respondents, 89% were aware of the factors contributing to AMR, but only 47% monitored developments and expanded their understanding of AMR. The most common antibiotic classes were penicillin (71), tetracyclines (50), sulfonamides (41), fluoroquinolones (31), and aminoglycosides (27).

Conclusion: All antimicrobials used in the animal health sector are also used in human medicine, which requires special consideration. This cross-use of antibiotics was a crucial factor in determining the cause of the spread of AMR between humans and animals.

Keywords: animal health, antimicrobial use, Yogyakarta.
Morphological and molecular characteristics of Plasmodium juxtanucleare in layer chicken from three districts of Yogyakarta, Indonesia
Authors: Dhamayanti Esti , Priyowidodo Dwi , Nurcahyo Wisnu , Firdausy Lintang Winantya
Published: August 2023

Background and Aim: Blood parasite infections in poultry, such as Plasmodium, are a serious threat to the poultry industry due to their potential to cause economic losses. To date, there has been inadequate research on the morphological and molecular detection of the different Plasmodium species that infect poultry in Indonesia. Therefore, this study aimed to analyze the morphological and molecular characteristics of Plasmodium spp. and the several predisposing factors for Plasmodium infection in layer chickens from three districts of Yogyakarta, Indonesia.

Materials and Methods: One hundred and five blood samples from layer chickens were collected from 13 farms located in three districts of Yogyakarta (Sleman, Bantul, and Kulon Progo) between September and November 2022. Blood samples were subjected to microscopic and polymerase chain reaction (PCR) analyses. Sequencing was performed using basic local alignment search tools to identify the nucleotide structure of cytochrome b. Phylogenetic analysis of Plasmodium was performed using the MEGA-X software.

Results: Microscopic examination revealed that 17/105 positives (16.19%) were positive for blood parasite infection. Trophozoites, erythrocytic meronts, and microgametocytes of Plasmodium were found in blood samples. Based on the morphological examination, the species found in the samples was close to Plasmodium juxtanucleare. Polymerase chain reaction examination revealed that 21/60 samples were positive for Plasmodium (35%). The Plasmodium species identified from the sequenced samples were proven to be P. juxtanucleare. The P. juxtanucleare from Thailand was closely related to samples (99.64%–100%) with a genetic distance of 0%–1%. In addition, age, population, and cage type were not significantly associated with Plasmodium infection.

Conclusion: Based on microscopic and PCR examinations, the Plasmodium species found in the three districts of Yogyakarta was P. juxtanucleare. The genetic distance between samples from the three districts of Yogyakarta was closely related (0%–1%) to P. juxtanucleare from Thailand and Japan. There was no correlation between Plasmodium infection and age, cage type, or population.

Keywords: avian malaria, cytochrome b gene, layer chicken, polymerase chain reaction.
Counteractive role of Terminalia catappa leaf extract on hematological and coagulation disturbance in Type 2 diabetic rats
Authors: Iheagwam Franklyn Nonso , Garuba Precious Amaneshi , Ogunlana Olubanke Olujoke , Chinedu Shalom Nwodo
Published: August 2023

Background and Aim: Diabetes mellitus is a leading cause of mortality worldwide associated with hyperglycemia-induced hematological aberrations and thromboembolic complications. This study aimed to explore the modulatory effect of Terminalia catappa leaf aqueous crude extract (TCLE) on hematological and coagulation disturbances in a Type 2 diabetic rat model.

Materials and Methods: High-fat diet streptozotocin-induced diabetic rats were treated orally with 400 and 800 mg/kg body weight TCLE daily for 28 days. Full blood count, coagulation parameters, plasma calcium (Ca), and erythrocyte glycogen (GLYC) levels were assessed using standard procedures.

Results: Terminalia catappa leaf aqueous crude extract treatment had a significant (p < 0.05) prolonging effect on clotting and bleeding times while increasing Ca, GLYC and mean corpuscular volume in diabetic rats. On the other hand, lymphocytes (LYM), platelet (PLT) count, mean PLT volume, neutrophil-LYM ratio (NLR), and PLT-LYM ratio (PLR) of TCLE-treated diabetic animals were significantly reduced (p < 0.05) compared with untreated diabetic animals. Lymphocyte, PLT count, NLR, and PLR correlated positively (p < 0.05) with plasma glucose, while a significant positive association was observed between Ca and GLYC. On the other hand, a strong negative association (p < 0.05) was observed between clotting time and fasting plasma glucose.

Conclusion: These findings suggest that T. catappa leaf extract may be useful in reversing diabetic-mediated hematological anomalies due to its anticoagulant and anti-anemic activities.

Keywords: coagulation, diabetes, hematology, high-fat diet, streptozotocin-induced, Terminalia catappa.