bluuebunny/crossref_metadata_2025 huggingface dataset:
Nephron Sparing Surgery Outcomes in Wilms’ Tumor: is it Ready for Primetime?
Authors: Imam Nareena , Burjonrappa Sathyaprasad
Published: August 2022

Purpose: Radical nephrectomy is the gold standard in Wilm’s tumor (WT) treatment and is combined with adjuvant treatment in early stage disease or performed after neo adjuvant therapy in advanced disease. With the development of novel adjuvant and neoadjuvant therapeutic strategies, there is increasing interest in organ preserving procedures in several adult malignancies. Potential long-term complications of living with a single kidney include hyperfiltration syndrome, hypertension, and fluid retention. If NSS (Nephron Sparing Surgery) were to be adopted for the treatment of WT it would be necessary to preserve the gains in Overall Survival (OS) seen with current treatment protocols. With this in mind we undertook a study of outcomes of NSS performed in the USA using a large population-based registry. Methods: We retrospectively queried the SEER Research Plus 18-registries Database 2010-2018 for patients 18 years old or younger with Wilms tumor as determined by ICD-O-3 code 8960. Clinical and demographic data was extracted, and statistical analysis was performed in GraphPad PRISM 9 with bivariate analysis and log-rank analysis to determine survival. Results:1087 patients with Wilms tumor were identified. 73 (6.72%) underwent nephron-sparing surgery. The final cohort consisted of 45 patients (64%) who underwent unilateral NSS and 25 patients (36%) who underwent bilateral NSS. Three were excluded from analysis due to non-renal origin of tumor. Mean age was 3.214 years (std dev 3.807). Demographics were similar between the groups, apart from younger age associated with bilateral tumor (p = 0.0441). No differences were found between radiation use (p=0.4280), chemotherapy use (0.5479), tumor size (p=0.2186), positive regional lymph nodes (p=0.5479). Log-rank analysis demonstrated that cancer-specific survival was not significantly different between unilateral and bilateral NSS or radical nephrectomy(p=0.4539). Conclusion: NSS may preserve renal function long-term, an important consideration in the pediatric population. Prospective study is necessary to select the appropriate patient subsets who may benefit from NSS in WT.
Induction of Phyllachora maydis (Maubl.) signs on corn leaves
Authors: Góngora-Canul Carlos , Jiménez-Beitia Fidel E. , Puerto-Hernández Carlos , Avellenada Mavir Carolina , Kleczewski Nathan , Telenko Darcy E. P. , Shim Sujoung , Solórzano José E. , Goodwin Stephen B. , Scofield Steven R. , Cruz C. D.
Published: August 2022

Objective: Tar spot is a foliar disease of corn caused by Phyllachora maydis, which produces signs in the form of stromata that bear conidia and ascospores. Phyllachora maydis cannot be cultured in media; therefore, the inoculum source for studying tar spot comprises leaves with stromata collected from naturally infected plants. Currently, there is no effective protocol to induce infection under controlled conditions. In this study, an inoculation method was assessed under greenhouse and growth chamber conditions to test whether stromata of P. maydis could be induced on corn leaves. Results: Experiments resulted in incubation periods ranging between 18 to 20 days and stromata development at the beginning of corn growth stage VT-R1 (silk). The induced stromata of P. maydis were confirmed by microscopy, PCR, or both. From thirteen experiments conducted, four (31%) resulted in the successful production of stromata. Statistical analyses indicate that if an experiment is conducted, there are equal chances of obtaining successful or unsuccessful infections. The information from this study will be valuable for developing more reliable P. maydis inoculation methods in the future.
Reduced lysosomal activity and increased amyloid beta accumulation in silica-coated magnetic nanoparticles-treated microglia
Authors: Shin Tae Hwan , Lee Gwang
Published: August 2022

Background
Nanoparticles have been used in neurological research in recent years because of their blood-brain barrier penetration activity. However, their potential neuronanotoxicity remains a concern. In particular, microglia, which are resident phagocytic cells, are mainly exposed to nanoparticles in the brain.
Methods
We investigated the changes in lysosomal function in silica-coated magnetic nanoparticles containing rhodamine B isothiocyanate dye [MNPs@SiO2(RITC)]-treated BV2 murine microglial cells. In addition, we analyzed amyloid beta (Aβ) accumulation and molecular changes through the integration of transcriptomics, proteomics, and metabolomics (triple-omics) analyses.
Results
Aβ accumulation significantly increased in the 0.1 µg/µl MNPs@SiO2(RITC)-treated BV2 cells compared to the untreated control and 0.01 µg/µl MNPs@SiO2(RITC)-treated BV2 cells. Moreover, the MNPs@SiO2(RITC)-treated BV2 cells showed lysosomal swelling, a dose-dependent reduction in proteolytic activity, and an increase in lysosomal swelling- and autophagy-related protein levels. Moreover, proteasome activity decreased in the MNPs@SiO2(RITC)-treated BV2 cells, followed by a concomitant reduction in intracellular adenosine triphosphate (ATP). By employing triple-omics and a machine learning algorithm, we generated an integrated single molecular network including reactive oxygen species (ROS), autophagy, lysosomal storage disease, and amyloidosis. In silico analysis of the single triple omics network predicted an increase in ROS, suppression of autophagy, and aggravation of lysosomal storage disease and amyloidosis in the MNPs@SiO2(RITC)-treated BV2 cells. Aβ accumulation and lysosomal swelling in the cells were alleviated by co-treatment with glutathione (GSH) and citrate.
Conclusions
These findings suggest that MNPs@SiO2(RITC)-induced reduction in lysosomal activity and proteasomes can be recovered by GSH and citrate treatment. These results also highlight the relationship between nanotoxicity and Aβ accumulation.
Unique case of pelvic congestion syndrome caused by a new communication branch of the portal-vena cava system
Authors: Zheng Wei , Sun Chun , Yang Jinming , Wu Yingfeng
Published: August 2022

Background: Congenital portosystemic shunt (CPS) is a developmental anomaly of the portal vein system. The disease can cause blood from the portal vein to flow into the vena cava, resulting in various atypical clinical manifestations. Pelvic congestion syndrome (PCS) caused by CPS is particularly rare.Case presentation: A young woman with PCS had an abnormal communicating branch of the left ovarian vein (OV). Her left OV drained normally into the left renal vein, and at the same time communicated with the portal vein, forming an extrahepatic portosystemic shunt. With embolization of her left OV, the patient was cured of PCS.Conclusions: Adequate knowledge of vascular variants helps clinicians in their treatment.
Chemoprevention by Microencapsulated Lactobacillus plantarum LAB12 against Orthotopic Colorectal Cancer Mice is Associated with Apoptosis and Anti-angiogenesis
Authors: Fareez Ismail M. , Lim Siong Meng , Ramasamy Kalavathy
Published: August 2022

The prevalence of colorectal cancer (CRC) has been widely linked to gut dysbiosis, a compositional imbalance of gut microbiota due to unhealthy lifestyles and dietary habits. Consumption of microencapsulated probiotic may potentially restore the compositional balance of gut microbiota in favour of prevention against CRC. In this regard, the present study was undertaken to determine the fate of microencapsulated Lactobacillus plantarum LAB12 in the gastrointestinal tract (GIT) and thereafter evaluate the chemopreventive effect of microencapsulated L. plantarum LAB12 in vivo. The targeted release of L. plantarum LAB12 from Alg-based microcapsules at different gut sections were examined by means of confocal microscopy and qPCR. Microcapsules loaded with L. plantarum LAB12 remained intact in the stomach. Free L. plantarum LAB12 were present in abundance (> 7 log CFU) only in the intestines. Subsequently, the chemopreventive properties of microencapsulated L. plantarum LAB12 were validated against NU/NU nude mice bearing orthotopic transplanted CT-26 CRC. Orthotopic mice pre-supplemented with microencapsulated L. plantarum LAB12 were presented with significantly (p < 0.05) reduced tumour volume (-98.87%) and weight (-89.27%) when compared to control. The chemopreventive effect could be attributed to apoptosis and anti-angiogenesis mediated, at least in part, through upregulation of p53 (+ 45.4%) and caspase-3 (+ 82.4%), and downregulation of COX-2 (-57.9%), VEGF (-66.8%) and PECAM-1 (-64.1%). Altogether, this study strongly implied the possibility of having L. plantarum LAB12-loaded microcapsules safely incorporated into a wide variety of food and nutraceutical products for prevention against CRC.
CAC-WOA: Context Aware Clustering with Whale Optimization Algorithm for Knowledge Discovery from Multidimensional Space in Electricity Application
Authors: Ahire Prashant , Patil Pramod
Published: August 2022

Due to the widespread use of smart metering infrastructure, multidimensional data on home electric consumption is easily available for studying its dynamics at finely resolved geographical and temporal scales. Effective forecasting and analysis of electric consumption are crucial for customer participation in time-of-use tariffs, critical peak pricing, and user-specific demand response programs derived from multidimensional data streams. Along with the enormous economic and sustainability ramifications, such as energy waste and the decarbonisation of the energy industry, precise consumption forecasts enable power system planning and reliable grid operations. Energy consumption forecasting is a hot field of research; despite the number of developed models, projecting electric consumption in residential buildings remains problematic owing to the significant unpredictability of occupant energy use behaviour. Discovering the electricity consumption knowledge from the Multi-Dimensional Data Streams (MDDS) of electricity logs is a challenging research problem. To end this, a novel electricity knowledge discovery model proposed from the MDDS using clustering and machine learning. Context-Aware Clustering with Whale Optimization Algorithm (CAC-WOA) is designed and explained in this research article. The CAC-WOA consists of two phases context-aware groups formation and WOA-based machine learning predictive model. In the CAC algorithm, group's formation using electricity contextual information to estimate the robust predictive features are proposed. Using such predictive features, the predictive model using the WOA-based Artificial Neural Network (ANN) is built. The modified ANN technique using the WOA algorithm is used to reduce the error rates and improve the prediction accuracy. The experimental outcomes using publically available electricity consumption datasets prove the efficiency of the CAC-WOA model.
A mathematical model for effective control and possible eradication of malaria
Authors: Adom-Konadu Agnes , Yankson Ernest , Naandam Samuel M. , Dwomoh Duah
Published: August 2022

In this paper, a deterministic mathematical model for the transmission and control of malaria is formulated. The main innovation in the model is that, in addition to the natural death rate of the vector (mosquito), a proportion of the prevention efforts also contributes to a reduction of the mosquito population. The motivation for the model is that in a closed environment, an optimal combination of the percentage of susceptible people needed to implement the preventative strategies (α) and the percentage of infected people needed to seek treatment can reduce both the number of infected humans and infected mosquito populations and eventually eliminate the disease from the community. Prevention effort α, was found to be the most sensitive parameter in the reduction of R0. Hence, numerical simulations were performed using different values of α to determine an optimal value of α that reduces the incidence rate fastest.It was discovered that an optimal combination that reduces the incidence rate fastest comes from about 40% of adherence to the preventive strategies coupled with about 40% of infected humans seeking clinical treatment as this will reduce the infected human and vector populations considerably.
Health, Mental Health, and Time Use: A Canadian Study
Authors: Latif Ehsan
Published: August 2022

Using data from Canadian General Social Survey (Time Use- 2015), the study examined how physical health and mental health are related to individuals' time use in sleep, personal care, non-market work, market work, and leisure. The study used Seemingly Unrelated Regression (SUR) and Tobit methods to estimate models. The study found that physical and mental health are negatively correlated with market hours and positively correlated with sleep and leisure. These results are consistent for both the male sample and the female sample. The study also focused on prime-age individuals and found that physical health and mental health significantly reduced time spent on work and significantly increased leisure time for both males and females.
Effect of heterologous platelet-rich plasma (PRP) on liver and modulation of glucose metabolism and Wnt signaling pathways in diabetic mice
Authors: Arif Amin , Farooq Adil , Abbasi Muddasir Hassan , Khawar Muhammad Babar , Akhter Tasleem , Ali Humaira Allay , Anjum Mehreen , Mahmood Rabia , Saleem Tayyaba , Sheikh Nadeem
Published: August 2022

Platelet-rich plasma (PRP) is proven a cost-effective therapeutic choice for different ailments. The current study was designed to highlight the effects of heterologous platelet-rich plasma (PRP) on deteriorated hepatic tissues and impaired glucose metabolism in alloxan-induced diabetic mice. A total of thirty (30) male mice were selected and grouped as control (CG), PRP group (PG), diabetic group (DG), treated group 1 (T1G), and treated group 2 (T2G). PG was given a subcutaneous dose of PRP (0.5 ml/kg body weight) twice a week for four weeks. DG, T1G, and T2G were first given a single dose of alloxan intraperitoneally (150 mg/kg) to induce diabetes. PRP (0.5 ml/kg body weight) was given twice a week to T1G and T2G for two and four weeks respectively. After four weeks, all the mice were sacrificed to excise liver for histological observations and gene expression analysis. Hepatic histo-morphological analysis revealed ballooning of hepatocytes, dilatation of sinusoids, and collagen deposition in the alloxan-induced diabetic group (DG) and it was significantly reduced in both T1G and T2G. Additionally, a significant change in the expression of several hepatic genes was observed. Fbp1, G6pc, and Pklr showed an upregulation while a downregulation was detected in the expression of Pck1 in DG. A significant restoration was observed in Fbp1, and G6pc after PRP treatment but no change was observed in Pklr expression. Genes of glycolytic pathway, Hk1 and Gck, were downregulated significantly in DG compared to CG and PRP treatment restore the expression in both treated groups T1G and T2G. Moreover, Wnt2, Wnt4, and Wnt9a genes of the Wnt signaling pathway were also upregulated in DG, conversely, downregulate in T1G and T2G. No significant change in expression of Wnt5b and Wnt9b was observed in DG compared to control. Current study revealed that PRP anticipates a reduction in glucose production and glucose consumption by ameliorating hepatic tissue and modulating the glucose metabolism. So, it may use as one of the adjunctive therapies to treat T2DM in future but further more detailed investigations are suggested.
The Wandering Spleen: Laparoscopic Splenectomy in a Pregnant Woman. Case Report and Review of the Literature
Authors: Crepaz Lorenzo , Leo Alberto Di , Borzellino Giuseppe , Pomini Paola , Genna Michele
Published: August 2022

Introduction: Wandering spleen (WS) is a rare condition, which is characterized by an augmented mobility of the spleen, due to congenital or acquired causes. It’s more frequent in multiparous women, but only a few cases are reported during pregnancy. WS is usually asymptomatic until the onset of ìts possible complications, and this can mislead clinicians in reaching the correct diagnosis.Case Report: We report the case of WS with acute splenic infarction in a pregnant woman and its mininvasive surgical treatment, focusing on the clinical and radiological findings that could mislead or drive clinicians to the right diagnosis, or to a potential disaster.Conclusion: Splenic preservation in WS where it’s safe and possible and is the main goal of the treatment. Clinical and radiological findings are the most relevant elements to drive surgical treatment.WS is an insidious condition, and must be included in differential diagnosis in determined cases, to reach the best and opportune treatment for the patient.
Comprehensive analysis of the expression and prognostic value for SNRP members in hepatocellular carcinoma
Authors: Guo Ziwei , Liang Jun
Published: August 2022

Background
Heterogeneity and epigenetic modifications lead to differences among treatment strategies, management and prognosis in hepatocellular carcinomas. The family of small nuclear ribonucleoprotein polypeptides (SNRPs) plays a crucial role in tumorigenesis and progression. However, the expression profile and prognostic impact of these family members are not clear. Here, we discuss the expression levels and prognosis of SNRPs. family members
Methods
We compared the transcript levels of each SNRPs member in pan-cancerous tissues by ONCOMINE and further analyzed the expression levels and tumor staging of these markers in hepatocellular carcinoma using UALCAN and GEPIA online databases, while assessing the prognostic value of their mRNA expression and performing functional enrichment analysis by Metascape software using Kaplan–Meier plotter database.
Results
These results showed that mRNA levels of each member of SNRP (B, D1, D2, D3, E, F, G) were significantly upregulated in hepatocellular carcinoma compared to normal tissue and were more highly expressed in patients with advanced hepatocellular carcinoma. mRNA expression of SNRPB, SNRPD1 and SNRPG was associated with poorer overall survival (OS), recurrence-free survival (RFS) and progression-free survival (PFS), which was considered to be statistically significant.
Conclusion
We systematically analyzed the mRNA expression and prognostic significance of each member of SNRPs in HCC and demonstrated the correlation, interaction network, gene alteration and functional enrichment among SNRPs members. Our data suggest that SNRPs members as oncogenes may be a potential indicator of HCC.
Ultra-high-resolution CT features of pulmonary nodules correlate with visceral pleural invasion in early stage lung adenocarcinoma
Authors: Li Lu , Li Huimin , Chen Xiaorong , Pan Jiangfeng , Wang Lixia , Shu Jiner , wu xiaoming
Published: August 2022

Background
visceral pleural invasion (VPI) is an important prognostic factor in early stage lung adenocarcinoma, which can affect the TNM Classification of Tumors.To investigate whether ultra-high-resolution computed tomography (U-HRCT) features can predict VPI of early stage pulmonary nodules contacting the interlobar pleura.
Methods
A total of 126 patients with lung adenocarcinoma (age, 24–77 years) confirmed by surgical pathology were retrospectively enrolled. All patients underwent U-HRCT scan and were divided into two groups according to pulmonary nodular type: pure (pGGN) and mixed (mGGN). Clinical features were recorded, and U-HRCT features were manually measured using PHILIPS EBW V4.5.5. Univariate and multivariate logistic regression were used to determine factors that can significantly predict VPI.
Results
U-HRCT and three-dimensional orthogonal post-processing method could better display the relationship between GGNs and interlobar fissures. Among all patients, fifteen patients (12%) had VPI. None of the patients with pGGN had VPI. In the mGGN group, the solid ratio (odds ratio [OR] = 1.275, 95% CI 1.1-1.478; P = 0.001) and solid diameter (OR = 1.139, 95% CI 1.06–2.346; P = 0.046) were independent risk factors for VPI in early stage lung adenocarcinoma. For VPI diagnosis, the area under the curve, sensitivity, and specificity of the solid ratio and solid diameter were 0.803, 80%, and 75% and 0.807, 80%, and 80.36%, respectively.
Conclusion
U-HRCT can display GGNs and interlobar fissures in detail. VPI was not detected in patients with pGGN. In patients with mGGNs, a solid diameter > 6mm and solid ratio > 38% can be independent predictors of VPI, which may be helpful in surgical decision-making.
Analysis of GPON capacity by hybrid splitting-ratio base on customer segmentation for Indonesian market during the Covid-19 pandemic
Authors: Hantoro Gunadi Dwi , Priambodo Purnomo S. , Wibisono Gunawan
Published: August 2022

During the Covid-19 pandemic, the impact on internet demand is very high throughout the world. In Indonesia, through a survey conducted, broadband users recorded 175 million people or equivalent to 64 % of the population. Based on field observations, the Passive Optical Network (PON) port utility in the Optical Line Terminal (OLT) is presently below 75 %, as opposed to the initial value, which was more than 95 % [1]. Furthermore, it was also found that more than 80 % of IndiHome customers use a maximum bandwidth of 20 Mbps with majority using 10 Mbps, which is very ineffective, especially related to network capacity. Generally, passive Optical Distribution Network (ODN) devices are not optimally used, therefore this research aims to determine the optimization level of the FTTH network by maximizing the available infrastructure capacity. This process was carried out by increasing the associate ratio of 1:32 to 1:64 while taking into account the Optical Line Terminal (OLT) capacity factor and the standard link budget with schemas A, B and C used to obtain adequate efficiency. Scheme A consists of a 1:2 passive splitter in the Optical Distribution Cabinet (ODC) & 1:32 at the Optical Distribution Point (ODP). Scheme B consists of a 1:4 (ODC) & 1:16 (ODP) passive splitter, while scheme C consists of a 1:8 (ODC) & 1:8 (ODP) passive splitter intended for the use of different customer area types. The result showed an increase in network capacity from 32 to 64 per PON port while taking into account the technical quality of the Link Budget. In conclusion, to ensure this solution functions properly, both simulation and direct measurement tests are carried out using the existing network
ASSESSMENT OF CIRCULAR ECONOMY AND REDUCTION OF EMBODIED CARBON DRIVE FOR SUSTAINABLE CONSTRUCTION
Authors:   M.E Student, Civil Department, NDMVPS KBTCOE, Nashik, Maharashtra., Bhadane Prerana , Nemade P.D. ,   HOD, Civil Department NDMVPS KBTCOE, Nashik, Maharashtra.
Published: August 2022

According to United Nations Environment Program 2020, construction industry uses almost 35 % of global energyand is responsible for 38 % of greenhouse gas emissions. Buildings areoe of the largest end-use sector and their contributioncontinues to be a source of that energy demand in the future. In this paper, a brief overview of assessment of circular economy and reduction of embodied carbon drive for sustainable construction is explained. The aim of the study is to analyze circular economy principal in construction industry for sustainable development. A brief introduction about circular economy (CE), need of study, problem statement, aim of study, and objectives of project are discussed in the paper.Theuse of timber as a structural element is slightly promoted concrete, minimize carbon footprints produced by use of steel and concrete.Majority of the buildings hasa mixture of compounds which are very difficult to filter/ separate, it makes the material reuse/ recycling process less easy, so new technologies to be used for separation of used building materials needs to be focused on.
CONVENTIONAL AND ADVANCED TECHNOLOGIES FOR BIOREMEDIATION OF WASTEWATER POLLUTANTS
Authors:   Department of Microbiology, B. K. Birla College of Arts, Science & Commerce (Autonomous), Kalyan-421301, (M.S.), India., Totewad N.D. , Patra Biswaranjan ,   Siksha O Anusandhan, Deemed to be University, Bhubaneshwar, Odisha, India., Warangkar Suchita ,   Department of Microbiology, Netaji Subhash Chandra Bose College, Nanded (M.S.)-431602, (M.S.), India.
Published: August 2022

In recent years, industrial as well as municipal wastewater discharges have caused great damage to water resources. Water pollution not only brings about imbalance in the ecological environment, but directly also affects human health. Therefore, there is an urgent need for scientists to develop effective wastewater purify technology to solve these significant issues. It is an essential to control and prevent unsystematic discharge of wastewater into the environment.Few of the reported strategies such as adsorption, filtration, centrifugation, catalysis, biological treatment and electro-coalescence, have been widely applied in wastewater treatment. But heavy energy utilization, non-repeatable usage and emergence of secondary pollution still seem to be inevitable. In this context some of the advanced, effective, and more reliable techniques have been discussed by showing their potency in removing different categories of pollutants which are present in respective type of wastewater. It has been shown that these advanced methods exhibited better performance than those of pre-existing conventional treatment methods with successfully overcoming the limitations associated with them. This review shows the potency of advanced methods which makes them suitable for getting integrated with those of conventional methods or else could be used singly in wastewater treatment plants (WWTPs) to tackle the current scenario.
VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF JANUMET XR (SITAGLIPTIN/METFORMIN HCL EXTENDED-RELEASE FIXED DOSE COMBINATION (FDC) CONTENT IN BULK AND PHARMACEUTICAL DOSAGE FORM
Authors:   Analytical Research & Development, Changzhou Pharmaceutical Factory, Changzhou - 213018, China., Santosh Kumar P. , a Wuchen ,   Analytical Research & Development, Changzhou Pharmaceutical Factory, Changzhou - 213018, China., b Liuzhen ,   Analytical Research & Development, Changzhou Pharmaceutical Factory, Changzhou - 213018, China., Shesha Battar Dheeraj ,   Formulation Research & Development, Changzhou Pharmaceutical Factory, Changzhou - 213018, China.
Published: August 2022

A simple, accurate, precise and rapid stability indicating reverse phase High performance chromatography method was used for estimation of Sitagliptin/metformin HCl ER tablets in bulk and fixed-dose combination solid oral dosage form. The proposed analytical method has been validated for specificity, Linearity, Accuracy, Precision and Robustness. The chromatography was achieved in a Avantor, ACE C18 (Length 150 x Diameter 4.6mm Particle size 5Âµm) column with gradient flow. The optimal chromatographic condition consisted of mobile phase pH 3.5 at a flow rate of 1.2 mL/min, with a column temperature of 35Â°C, run time 17 minutes and detector wavelength of 210 nm (Sitagliptin& Propyl gallate and Metformin HCl).
ECOFRIENDLY AND CONVENIENT SYNTHESIS OF SOLID STATE FLUORINATED QUINOLINYL PHTHALAZINE -1, 4-DITHIONES
Authors:   Department of Chemistry, Chaitanya (Deemed to be University), Hanamkonda, Telangana State-506001., Swamy J. Kumara , Venkatesh Shaganti ,   Department of Chemistry, Chaitanya (Deemed to be University), Hanamkonda, Telangana State-506001., Shireesha Kavati ,   Department of Chemistry, Chaitanya (Deemed to be University), Hanamkonda, Telangana State-506001., Srilekha Adaboina ,   Department of Chemistry, Chaitanya (Deemed to be University), Hanamkonda, Telangana State-506001.
Published: August 2022

A new series of fluorinated quinoline -1,4-dithiones 3(a-f) were obtained by the treatment of 3-aryl-2-hydrazino-quinolines 1(a-f) with isobenzo furan-1,3-dithione 2 in the presence of p- toluene sulphonic acid (PTSA) in the solid state at room temperature as one pot. All the products are monitored by TLC and isolated by GC and furthermore confirmed by spectral analysis.
FUNCTIONAL AND RADIOLOGICAL OUTCOMES OF DISPLACED MID SHAFT CLAVICLE FRACTURES MANAGED OPERATIVELY BY PRECONTOURED LOCKING PLATE
Authors:   Post-Graduate Resident Department of Orthopaedics, Government Medical College, Jammu., Singh Gagandeep , Singh Raina Gagandeep ,   Senior Resident Department of Orthopaedics, Government Medical College, Jammu., Gupta Sanjeev ,   Professor and Head, Department of Orthopaedics, Government Medical College, Jammu.
Published: August 2022

Background: Clavicle fracture is commonly managed conservatively but non cosmetic appearance and non union in few cases has led to increase in number of cases being managed operatively. In this study , we studied the functional and radiological outcome of clavicle fracture managed by plating. Material and Methods: A prospective study was conducted in GMC jammu on 30 patients from March 2020 to March 2021 . Patients were operated with precontoured 3.5mm compression plate over superior aspect of clavicle and patients were followed up at 2, 4, 6, 12 and 24 weeks post operatively. Results: In our study , mean time for union was 14.7 weeks with no patient reporting non union .Range of motion at shoulder joint was near normal and patients reported high VAS scores. Conclusion: Open reduction and internal fixation with precontoured compression plate for mid shaft clavicle fracture gives good functional and radiological outcomes with high patient satisfaction rates and without any major complications.
Structure of local government budgets and local fiscal autonomy: Evidence from Indonesia
Authors: Musviyanti  , Nur Khairin Fibriyani , Bone Hariman , Abadan Syakura Muhammad , Yudaruddin Rizky
Published: August 2022

This study aimed to investigate the critical aspects of Indonesia’s local government budget structure. The impact of the budget on local fiscal autonomy was also examined by separating the sample of provinces in Java Island and Bali versus Non-Java Island and Bali. The unbalanced panel data was collected on 34 Indonesian provinces from 2013 to 2020. The results showed that locally-generated revenue and general allocation funds positively affect the regional fiscal autonomy index. These results indicate that local revenue and general allocation funds have improved regional fiscal autonomy. When the provincial sample is separated, general allocation funds positively and significantly affect the regional fiscal autonomy index in the provinces of Java Island and Bali. Furthermore, locally-generated revenue, as well as general allocation and profit-sharing funds, play a significant role in increasing the regional fiscal autonomy index in provinces outside Java and Bali, such as Sumatra, Kalimantan, Sulawesi, and Papua. These findings suggest that different geographical conditions and infrastructure have varying effects on encouraging regional fiscal autonomy. This study invites policymakers to address the strengthening of regional authority to explore income sources and budgeting quality and evaluate intergovernmental fiscal relationships.
AcknowledgmentThe authors express gratitude to the three anonymous reviewers and seminar attendees at Mulawarman University for their insightful comments.
GOOGLE TRENDS “ALTIN” ARAMALARI İLE ALTIN FİYATLARI ARASINDAKİ İLİŞKİNİN ANALİZİ
Authors: YÜRÜK Muhammed Fatih , KAYA Zekayi
Published: July 2022

With the rapid development of information technologies, the coverage area of the internet network is also growing. The development of information technologies has brought with it the concept of "big data". Those who use this data will have an advantage over their competitors. Use of big data; From science to industry, from the private sector to the public, it is now important in many fields. In this study, the causality connection of the course of gold prices was examined by using the data obtained from Google Trends, which presents the search frequency of the keyword searched in the Google search engine. The data set includes monthly data between 01.01.2004-01.12.2021. The scope of the study is on the search frequency of the "gold" keyword in the Google search engine within the borders of Turkey. In the study, the stationarity of the data was analyzed, and then the Johansen cointegration test was used to determine the long-term balance between the variables. The last step was Granger Causality Analysis. As a result of the study, one-way Granger causality towards gold prospecting was determined.

Keywords: Google, Google Trends, Big Data, Granger
The Conceptual and Pragmatic Transformation of Security Perception in Turkey: A Periodic Comparison
Authors: ASLAN Murat
Published: July 2022

Türkiye 12 Eylül 1980 ihtilalinden itibaren güvenlik algılarında dönüşümü tecrübe ederek yaşamış, kimi zaman tabi olduğu yapının kimi zaman da iç güvenlik bağlamında güvenliğin kavramsal ve pratik dönüşümüne tabi olmuştur. Yapısal faktörlerin dikte koşullar ve çarpan etkisi yaratan kısıtları veya yönlendirmeleri istikametinde iç ve bölgesel sorunlar ile tecrübe edilen fiili dönüşüm Türkiye’yi temposu gittikçe artan güvenlikleştirme sarmalına tabi kılmıştır. Önceleri güvenliğini yapının teminatları ile sağlamaya çalışan Türkiye, yapıdaki dönüşüm karşısında geleneksel güvenlik okumalarını terk etme ihtiyacı hissetmiştir. Bu çerçevede iktidarlara veya bölgesel/yapısal dönüşümlere bağlı olarak Türkiye, sırasıyla; uluslararası yapıya endeksli, doğrudan tehditlere mukabelede bulunan ve pro-aktif bir güvenlik stratejisi izlemeye itmiştir. Türkiye’nin güvenliği deruhte etmede izlediği yöntem dış dünyada ‘yayılmacı’ olarak algılanmıştır. Ancak yeni dönemde kavramlar güvenlik olaylarını açıklamada geç kalmakta ve devlet dışı aktörlerin de yer olduğu yeni yapıda devlet aktörlerin güvenlikleştirme süreçlerinde sert – yumuşak tehditlere yönelik çok katmanlı, esnek ve alternatifli olmasını gerektirmektedir. Araştırmada Türk siyasi tarihinin modern dönüm noktaları esas alınarak bahse konu güvenlik algısı dönüşümü incelenmiş ve modern dönemde tercih edilen güvenlikleştirmeye yönelik değerlendirme yapılmıştır.
Optical property of dissolved organic matter and its correlation with heavy metals in surface water around metal mines to be exploited in southern Anhui Province, China
Authors: Yu Hao , Feng Songbao
Published: August 2022

In this study, we aimed to clarify the optical characteristics of dissolved organic matter (DOM) in the surface water around the metal mine to be exploited and its relationship with heavy metals. In total 11 pond water samples and 21 river water samples were collected around the typical to be exploited metal mine in southern Anhui Province, China. The optical properties of DOM in surface water were studied using ultraviolet-visible (UV-Vis) spectroscopy and excitation-emission matrix (EEM) spectroscopy. Co-occurrence network analysis revealed the intrinsic relationship among UV-Vis spectral parameters, fluorescent components, and heavy metals. The results showed that the DOM in the river had higher content, but its molecular weight was smaller than in the pond. EEM coupled with parallel factor analysis (EEM-PARAFAC) revealed humic-like components (C1 and C2) and protein-like components (C3), and the average content of each fluorescent component in the river was higher than that in the pond. However, except for As, the average content of other heavy metals (Cr, Cu, Cd, Pb, and Zn) in ponds was more significant than in rivers. The co-occurrence network analysis result revealed that there might be different relationships between heavy metals and the DOM due to the various land use.
Tecnologia Social para o Enfrentamento da Condição de Pobreza no Brasil
Authors: Castilho Cláudio Jorge Moura de
Published: August 2022

O presente artigo destaca a relevância no que se refere à apropriação e ao uso da tecnologia social, de modo autônomo e democrático, no processo de enfrentamento à condição de pobreza em territórios das classes trabalhadoras empobrecidas em Recife-PE, Brasil. Compreende-se, portanto, a tecnologia social como um conjunto de técnicas, ao mesmo tempo, materiais e imateriais produzidas e apropriadas pela própria sociedade territorialmente contextualizada no âmbito da sua própria dinâmica histórica. A revisão bibliográfica e alguns resultados das experiências empíricas desenvolvidas pelo grupo de pesquisa Movimentos Sociais e Espaço Urbano nos referidos territórios foram alguns dos procedimentos metodológicos utilizados para a operacionalização do método dialético de abordagem pelo qual se optou para a discussão ora estabelecida. Conclui-se a reflexão ressaltando a relevância da criação e do uso, de modo autônomo e democrático, de formas diversas de tecnologia social como mais uma contribuição à transformação das condições de pobreza das classes trabalhadoras empobrecidas.
Práticas Científicas identificadas nas ações docentes em aulas de Química
Authors:   Universidade Estadual de Londrina, Londrina, Brasil., Dos Santos Noraa Paulo , Dias Broietti Fabiele Cristiane ,   Universidade Estadual de Londrina, Londrina, Brasil.
Published: August 2022

Este artigo apresenta resultados de uma investigação na qual foram identificados e analisados indícios de Práticas Científicas em aulas de química, nas ações docentes. Trata-se de uma investigação predominantemente qualitativa fundamentada nos pressupostos metodológicos da análise de conteúdo. Para a recolha de dados, foram gravadas as aulas de química, de caráter expositiva e experimental, que versavam a respeito de propriedades periódicas e ligações químicas, ambas lecionadas em turmas do Ensino Médio. Mediante as análises chegamos aos seguintes resultados: identificou-se sete das oito Práticas Científicas, mencionadas no NRC (2012), sendo as três mais expressivas: PC1 – Fazer perguntas, PC3 – Planejar e realizar investigações e PC6 – Construir explicações. O reconhecimento de tais Práticas Científicas permitiu-nos traçar um perfil específico das aulas. As aulas expositivas centraram-se na explicação (PC6) do conteúdo de algumas propriedades periódicas, sendo orientadas por perguntas (PC1) que permitiram aprofundar e explicar os tópicos estudados. Na aula experimental, a ênfase das ações docentes foi na realização de investigação sistemática (PC3), permitindo que os estudantes realizassem as experiências. Também observamos nesta aula a incidência de (PC1), realizada pelo professor e dirigida a cada grupo, levando os estudantes a refletirem sobre aspectos da experiência. Salientamos que, embora tenham sido identificadas diferentes Práticas Científicas nas aulas investigadas, acreditamos que se o professor conhece previamente, e de forma mais aprofundada, cada uma das PC, poderá planejar e conduzir as suas aulas procurando diversificá-las, permitindo um ensino e uma aprendizagem de Química em que o estudante assume um papel mais ativo no processo.
A Systematic Review and Meta-Analysis on the Effect of Flavonoids
on Insulin-like Growth Factor and Insulin-like Growth Factor
Binding Protein and Incidence of Breast Cancer
Authors: Nasr Shiva , Nakisa Athar , Jandaghian Setareh , Kouhi Monireh , Sadeghi Erfan , Varshosaz Jaleh
Published: August 2022

Background:

Insulin-like growth factor (IGF-1) is associated with breast cancer
in menopausal women. Naturally occurring biomolecules found in common dietary
protocols, such as flavonoids, play a key role in the inhibition and treatment of cancer.
In-vitro/in-vivo studies showed that treatment involving flavonoids led to a reduced risk
of breast cancer due to the decrease of IGF-1 level in addition to an increased insulin-like
growth factor binding protein (IGFBP)-3. However, clinical studies did not show conclusive
results in this regard because they are contradictory.

Objective:

The aim of the present study was to find the effect of flavonoids on IGF-1 and
IGFBP-3 and the incidence of breast cancer.

Methods:

This systematic review was performed using PubMed, Scopus, ISI Web of Science,
and EMBASE databases to collect results about the clinical use of flavonoids and
their effects on breast cancer. After eliminating duplicate articles, the title and abstract of
the remaining articles were examined in thematic communication, and related clinical articles
were selected and studied based on inclusion criteria. The data were extracted from
each article, and then statistical analysis was subsequently carried out by Comprehensive
Meta-Analysis.

Results:

The results showed that the effect of flavonoids on changes in IGF1 and
IGFBP-3 was not statistically significant. No significant heterogeneity was detected
across the studies. Pooled effect size also indicated that the mean change was not statistically
significant. No significant heterogeneity was detected across the studies. There was
no evidence of publication bias for IGF1 and IGFBP-3.

Conclusion:

This meta-analysis study suggests that flavonoid supplementations have no
significant effect on IGF-1 and IGFBP-3, and a high soy diet has beneficial effects on
IGF system components, which might be useful in breast cancer.
Lyophilization of Molecular Biology Reactions: A Review
Authors: Aoki Mateus Nóbrega , Prado Nayra Oliveira , Lalli Larissa Araújo , Blanes Lucas , Zanette Dalila Lucíola
Published: August 2022

Molecular biology is a widely used and widespread technique in research and as a laboratory
diagnostic tool, aiming to investigate targets of interest from the obtainment, identification,
and analysis of genetic material. In this context, methods, such as Polymerase Chain Reaction
(PCR), Reverse Transcription Polymerase Chain Reaction (RT-PCR), real-time PCR, loopmediated
isothermal amplification (LAMP), and loop-mediated isothermal amplification with reverse
transcription (RT-LAMP), can be cited. Such methods use enzymes, buffers, and thermosensitive
reagents, which require specific storage conditions. In an attempt to solve this problem,
the lyophilization procedure (dehydration process by sublimation) can be applied, aiming to preserve
and prolong the useful life of the reaction components in cases of temperature variation. In
this review, we present a synthesis of the lyophilization process, describing the events of each step
of the procedure and providing general information about the technique. Moreover, we selected
lyophilization protocols found in the literature, paying attention to the conditions chosen by the
authors for each step of the procedure, and structured the main data in tables, facilitating access to
information for researchers who need material to produce new functional protocols.
Modified Risk Tobacco Products and Cardiovascular Repair: Still Very
“Smoky”
Authors: Cozzolino Claudia , Picchio Vittorio , Floris Erica , Pagano Francesca , Saade Wael , Peruzzi Mariangela , Frati Giacomo , Chimenti Isotta
Published: August 2022

Smoking habits represent a cardiovascular risk factor with a tremendous impact on health.
Other than damaging differentiated and functional cells of the cardiovascular system, they also negatively
affect reparative mechanisms, such as those involved in cardiac fibrosis and in endothelial progenitor cell
(EPC) activation. In recent years, alternative smoking devices, dubbed modified tobacco risk products
(MRPs), have been introduced, but their precise impact on human health is still under evaluation. Also,
they have not been characterized yet about the possible negative effects on cardiovascular reparative and
regenerative cells, such as EPCs or pluripotent stem cells. In this perspective, we critically review the still
scarce available data on the effects of MRPs on molecular and cellular mechanisms of cardiovascular
repair and regeneration.
Microencapsulation of nutmeg essential oil (Myristica fragrans) via spray drying: effects of feed emulsion parameters on emulsion and powder characteristics
Authors: Kemala Putri Jauhari Ana , Gerry Septian Riseno Jou , Hidrotunnisa Hidrotunnisa
Published: July 2022

Nutmeg essential oil (Myristica fragrans) is susceptible to deterioration and chemically unstable when exposed to the environment, resulting in a loss of bioactive compounds and the development of off-flavors. Microencapsulation is then used to enhance shelf stability and nutritional value. This study aimed to attempt the nutmeg essential oil encapsulation, utilizing the spray drying technique by analyzing the effect of emulsion parameters. An array of process parameters including wall material content (7, 8, and 9%), the mass ratio of carrageenan to soy protein isolate (1:2, 1:1, 2:1), and concentration of essential oil (25, 50, and 75%) were thoroughly investigated. The results showed that almost all parameters significantly influence (p < 0.05) on determining emulsion and powder quality. The microencapsulation process with a mass ratio of carrageenan to soy protein isolate of 1:2 gave better microcapsules characteristics than other powders. The microencapsulation process that was performed with a solid content of 7% as wall material and nutmeg essential oil at the concentration of 25% as core material showed the best performance, resulting in the highest solid yield (83.33±0.37%) with good emulsion characteristics (i.e. stability, viscosity, and diameter droplet) and powder properties (i.e. moisture content, total solid, hygroscopicity, and color).
Combination of FOBIO biopesticide and Brassica rapa L. as remediator of heavy metal Pb in soil
Authors: Ari Widya Surya , Arifin Moch. , Wiyatiningsih Sri
Published: July 2022

Marginal soil is infertile soil caused by various factors, one of which is the excessive accumulation of heavy metals. FOBIO microorganism-based biopesticide formula containing phosphate solubilizing bacteria is expected to be used to reduce excess heavy metals in the soil. Brasica rapa L. is a variety resistant to Pb heavy metal stress and absorbs more heavy metals into root tissue than leaf tissue with the help of microorganisms. This study aimed to determine the combination of Brassica rapa L. and FOBIO biopesticide in absorbing Pb in the soil, determine the growth of Brassica rapa L. at each Pb concentration, and determine the population of phosphate-solubilizing bacteria in the soil at each level of Pb stress after remediation. This study used variations in the concentration of heavy metals, particularly Pb. Parameters observed included plant growth, Pb concentration in the soil before and after remediation, and the population of phosphate-solubilizing bacteria. The results showed that combining FOBIO biopesticides and Brassica rapa L. could reduce Pb concentration in the soil. The growth of Brassica rapa L. plants was significantly different after treatment. The findings confirmed that increasing, the concentration of Pb led to a decrease in the population of phosphate-solubilizing bacteria.
Adiciones al listado de plantas ornamentales urbanas de Tunja (Boyacá-Colombia)
Authors: Díaz Pita Mónica Patricia , Álvaro Alba Wilson Ricardo , Porras Flórez Daniela , Lagos López Mayer Isnardo
Published: August 2022

Se adicionan 89 nuevos registros de especies al listado de plantas ornamentales urbanas de Tunja (Boyacá). Esta contribución se presenta a manera de catálogo con tres grupos taxonómicos, Pteridophyta (2 familias, 2 géneros y 2 especies), Eudicotiledónea (21 familias con 47 géneros, 72 especies y 1 cultivar) y Monocotiledónea (7 familias, 12 géneros y 15 especies). Dentro de las familias, la más importantes a nivel de riqueza fueron Cactaceae (con 13 géneros y 21 especies) y Crassulaceae (con 8 géneros y 21 especies); por consiguiente, el hábito de crecimiento que predominó fueron las suculentas.  Se proporciona información como nombre común y origen de cada especie y adicionalmente se incluyen fotografías.