bluuebunny/crossref_metadata_2025 huggingface dataset:
Oral Microbiota Profile in a Group of Anti-AChR Antibody–Positive Myasthenia Gravis Patients
Authors: Huang Chao , Gao Feng , Zhou Haitao , Zhang Li , Shang Dandan , Ji Ying , Duan Zhihui
Published: July 2022

Myasthenia gravis (MG) is an autoimmune disorder caused by autoantibodies directed against the postsynaptic membrane at the neuromuscular junction. Perturbation of gut microbiota is thought to contribute to the development of MG, as reflected by fecal metabolomic signatures in humans, but there have been few studies on the relationship between oral microbiota profile and MG. The current study evaluated the correlation between oral microbiota composition and diversity and anti-acetylcholinereceptor (AChR) antibody–positive MG by comparing oral microbiota communities of patients (n = 20) and healthy controls (HCs; n = 20) by 16S rRNA gene sequencing. Principal coordinate analysis and Adonis analysis revealed significant differences in oral microflora profile between the twogroups. Compared to HCs, the abundance of the phyla Firmicutes and Actinobacteria and genera Streptococcus, Rothia, and Lachnoanerobaculum was significantly increased whereas that of phyla Proteobacteria and Spirochaetotaand genera Neisseria, Haemophilus, and Treponema was significantly decreased in MG patients. The Kyoto Encyclopedia of Genes and Genomes pathway analysis showed that the biosynthesis of ansamycins and amino acid metabolism pathways were altered in MG. These results indicate that oral microbiota composition is perturbed in patients with anti-AChR antibody–positive MG, providing new potential avenues for targeted therapeutic interventions.
Transcranial Direct Current Stimulation in Treatment of Child Neuropsychiatric Disorders: Ethical Considerations
Authors: Auvichayapat Narong , Auvichayapat Paradee
Published: July 2022

Transcranial direct current stimulation (tDCS) is a noninvasive electrical stimulation performed using low electric currents passing through two electrodes. The provided current passes from the anode to the cathode and induces electric fields in the surface neurons. It then modulates synaptic plasticity and finally changes cortical excitability or improves clinical outcomes, which outlast after a duration of stimulation. Meta-analyses have supported the beneficial effects of tDCS treatments in child neuropsychiatric disorders. However, the study of vulnerable children remains controversial and is a great deal for ethical considerations. Because the developing brain has some important physiological differences from the matured brain, specifically less γ-aminobutyric acid (GABA)ergic inhibition and more myelination, the opportunity to modify neurological disorders to be close to the normal level in childhood after tDCS is likely to be higher than in adults. In contrast, these physiological differences may result in unexpected excitability in children's brains and were criticized to have an unsafe effect, specifically seizures, which is a serious adverse events. As mentioned above, using tDCS in children appears to be a double-edged sword and should be ethically considered prior to wide use. Assessing between benefits of tDCS treatment within the golden period of brain development and the risk of seizure provocation is important. Thus, this perspective article is aimed to exhibit broad concepts about the developing brain, tDCS in children, pathophysiology of neuropsychiatric disorders and tDCS beneficence, tDCS safety and tolerability in children, and missing good opportunities or taking risks in tDCS.
Dietary Goji Shapes the Gut Microbiota to Prevent the Liver Injury Induced by Acute Alcohol Intake
Authors: Guo Lin , Guan Qijie , Duan Wenhui , Ren Yilin , Zhang Xiao-Juan , Xu Hong-Yu , Shi Jin-Song , Wang Fang-Zhou , Lu Ran , Zhang Hui-Ling , Xu Zheng-Hong , Li Huazhong , Geng Yan
Published: July 2022

Diet is a major driver of the structure and function of the gut microbiota, which influences the host physiology. Alcohol abuse can induce liver disease and gut microbiota dysbiosis. Here, we aim to elucidate whether the well-known traditional health food Goji berry targets gut microbiota to prevent liver injury induced by acute alcohol intake. The results showed that Goji supplementation for 14 days alleviated acute liver injury as indicated by lowering serum aspartate aminotransferase, alanine aminotransferase, pro-inflammatory cytokines, as well as lipopolysaccharide content in the liver tissue. Goji maintained the integrity of the epithelial barrier and increased the levels of butyric acid in cecum contents. Furthermore, we established the causal relationship between gut microbiota and liver protection effects of Goji with the help of antibiotics treatment and fecal microbiota transplantation (FMT) experiments. Both Goji and FMT-Goji increased glutathione (GSH) in the liver and selectively enriched the butyric acid-producing gut bacterium Akkermansia and Ruminococcaceae by using 16S rRNA gene sequencing. Metabolomics analysis of cecum samples revealed that Goji and its trained microbiota could regulate retinoyl β-glucuronide, vanillic acid, and increase the level of glutamate and pyroglutamic acid, which are involved in GSH metabolism. Our study highlights the communication among Goji, gut microbiota, and liver homeostasis.
Diffusion Breast MRI: Current Standard and Emerging Techniques
Authors: Mendez Ashley M. , Fang Lauren K. , Meriwether Claire H. , Batasin Summer J. , Loubrie Stéphane , Rodríguez-Soto Ana E. , Rakow-Penner Rebecca A.
Published: July 2022

The role of diffusion weighted imaging (DWI) as a biomarker has been the subject of active investigation in the field of breast radiology. By quantifying the random motion of water within a voxel of tissue, DWI provides indirect metrics that reveal cellularity and architectural features. Studies show that data obtained from DWI may provide information related to the characterization, prognosis, and treatment response of breast cancer. The incorporation of DWI in breast imaging demonstrates its potential to serve as a non-invasive tool to help guide diagnosis and treatment. In this review, current technical literature of diffusion-weighted breast imaging will be discussed, in addition to clinical applications, advanced techniques, and emerging use in the field of radiomics.
The Clinical Observation of Acupuncture Combined With Antiemetic Drugs in the Prevention and Treatment of CINV in Breast Cancer Patients
Authors: Kong Fanming , Wang Ziwei , Wang Na , Zhao Lu , Mei Qingyun , Yu Yongchao , Zhang Dou , Li Xiaojiang , Jia Yingjie
Published: July 2022

Objective

The present study aimed to explore the effectiveness of acupuncture combined with antiemetic drugs in prevention and treatment of chemotherapy-induced nausea and vomiting (CINV) among breast cancer patients receiving postoperative adjuvant chemotherapy.

Methods

We retrospectively collected the clinical records of 81 postoperative breast cancer patients at our hospital from January 2021 to December 2021. These patients were divided into the acupuncture group and the control group. The efficacy of the antiemetic drugs combined with acupuncture for CINV was analysed. The primary endpoints were total, acute, and delayed nausea and vomiting grade and remission rate. Safety and overall patient quality of life were secondary endpoints.

Results

During the whole observation period, compared with the control group, the frequency of nausea and vomiting was decreased in the acupuncture group (P=0.034). And the ECOG-PS score in the acupuncture group was significantly improved (P=0.004). In addition, the adverse events, such as abdominal (12.2% vs. 5.0%, P=0.252), distention (19.5% vs. 5.0%, P=0.049), and diarrhea (9.7% vs. 0, P=0.044), were decreased by acupuncture.

Conclusions

Acupuncture combined with antiemetics could reduce the incidence of CINV, improve the quality of life of patients and reduce the incidence of adverse side effects of antiemetic drugs.
Triggering Receptors Expressed on Myeloid Cells 1 : Our New Partner in Human Oncology?
Authors: Muller Marie , Haghnejad Vincent , Lopez Anthony , Tiotiu Angelica , Renaud Stéphane , Derive Marc , Bronowicki Jean-Pierre
Published: July 2022

Inflammation is recognized as one of the hallmarks of cancer. Indeed, strong evidence indicates that chronic inflammation plays a major role in oncogenesis, promoting genome instability, epigenetic alterations, proliferation and dissemination of cancer cells. Mononuclear phagocytes (MPs) have been identified as key contributors of the inflammatory infiltrate in several solid human neoplasia, promoting angiogenesis and cancer progression. One of the most described amplifiers of MPs pro-inflammatory innate immune response is the triggering receptors expressed on myeloid cells 1 (TREM-1). Growing evidence suggests TREM-1 involvement in oncogenesis through cancer related inflammation and the surrounding tumor microenvironment. In human oncology, high levels of TREM-1 and/or its soluble form have been associated with poorer survival data in several solid malignancies, especially in hepatocellular carcinoma and lung cancer. TREM-1 should be considered as a potential biomarker in human oncology and could be used as a new therapeutic target of interest in human oncology (TREM-1 inhibitors, TREM-1 agonists). More clinical studies are urgently needed to confirm TREM-1 (and TREM family) roles in the prognosis and the treatment of human solid cancers.
Comprehensive Analyses of miRNAs Revealed miR-92b-3p, miR-182-5p and miR-183-5p as Potential Novel Biomarkers in Melanoma-Derived Extracellular Vesicles
Authors: Gerloff Dennis , Kewitz-Hempel Stefanie , Hause Gerd , Ehrenreich Jovine , Golle Linda , Kingreen Tim , Sunderkötter Cord
Published: July 2022

Extracellular vesicles (EVs) are important mediators in the intercellular communication, influencing the function and phenotype of different cell types within the tumor micro-milieu and thus promote tumor progression. Since EVs safely transport packages of proteins, lipids and also nucleic acids such as miRNAs, EVs and their cargo can serve as diagnostic and prognostic markers. Therefore, the aim of this study was to investigate EV embedded miRNAs specific for melanoma, which could serve as potential biomarkers. In contrast to previous studies, we not only analysed miRNAs from EVs, but also included the miRNA profiles from the EV-secreting cells to identify candidates as suitable biomarkers. While the characterization of EVs derived from normal melanocytes and melanoma cells showed largely comparable properties with regard to size distribution and expression of protein markers, the NGS analyses yielded marked differences for several miRNAs. While miRNA load of EVs derived from normal human epidermal melanocytes (NHEMs) and melanoma cells were very similar, they were highly different from their secreting cells. By comprehensive analyses, six miRNAs were identified to be enriched in both melanoma cells and melanoma cell-derived EVs. Of those, the accumulation of miR-92b-3p, miR-182-5p and miR-183-5p in EVs could be validated in vitro. By functional network generation and pathway enrichment analysis we revealed an association with different tumor entities and signaling pathways contributing melanoma progression. Furthermore, we found that miR-92b-3p, miR-182-5p and miR-183-5p were also enriched in EVs derived from serum of melanoma patients. Our results support the hypothesis that miRNAs derived from EVs can serve as prognostic or diagnostic liquid biopsy markers in melanoma. We identified EV-derived miRNAs and showed that those miRNAs, which were enriched in melanoma cells and EVs, are also found elevated in serum-derived EVs of patients with metastatic melanoma, but not in healthy subjects.
Polo-Like Kinase 2: From Principle to Practice
Authors: Zhang Chuanyong , Ni Chuangye , Lu Hao
Published: July 2022

Polo-like kinase (PLK) 2 is an evolutionarily conserved serine/threonine kinase that shares the n-terminal kinase catalytic domain and the C-terminal Polo Box Domain (PBD) with other members of the PLKs family. In the last two decades, mounting studies have focused on this and tried to clarify its role in many aspects. PLK2 is essential for mitotic centriole replication and meiotic chromatin pairing, synapsis, and crossing-over in the cell cycle; Loss of PLK2 function results in cell cycle disorders and developmental retardation. PLK2 is also involved in regulating cell differentiation and maintaining neural homeostasis. In the process of various stimuli-induced stress, including oxidative and endoplasmic reticulum, PLK2 may promote survival or apoptosis depending on the intensity of stimulation and the degree of cell damage. However, the role of PLK2 in immunity to viral infection has been studied far less than that of other family members. Because PLK2 is extensively and deeply involved in normal physiological functions and pathophysiological mechanisms of cells, its role in diseases is increasingly being paid attention to. The effect of PLK2 in inhibiting hematological tumors and fibrotic diseases, as well as participating in neurodegenerative diseases, has been gradually recognized. However, the research results in solid organ tumors show contradictory results. In addition, preliminary studies using PLK2 as a disease predictor and therapeutic target have yielded some exciting and promising results. More research will help people better understand PLK2 from principle to practice.
Urethral Plate Characteristics in Cases of Non-proximal Hypospadias May Not Be Associated With a Higher Risk of Complications When a Two-Stage Repair Is Applied
Authors: Marcou Marios , Bobbe Sarah-Magdalena , Wullich Bernd , Hirsch-Koch Karin
Published: July 2022

Purpose

To investigate whether a two-stage repair of distal- and mid-shaft hypospadias (non-proximal hypospadias) could eliminate the risk factors resulting from adverse urethral plate characteristics and eventually reduce complication rates.

Methods

We retrospectively reviewed all cases of primary surgical repair of non-proximal hypospadias performed in our center between 2009 and 2018. In all cases where adverse urethral plate characteristics were found, such as meatal stenosis, a shallow urethral groove, a thick web of tissue between the native meatus and the urethral groove or in the presence of a very “thin,” skin-like distal urethra, a two-stage repair was routinely undertaken. In cases of native meatal stenosis, a meatotomy, and meatoplasty were performed. In cases of a very “thin” distal urethra we incised the skin proximally up to the point of a normal urethral fold and a meatoplasty was performed at that point. Hypospadias repair was then performed in a second operation, 3–6 months following the first procedure. Urethroplasty, both in cases of a single-stage repair and in cases of a two-stage repair, was always performed using the Thiersch-Duplay technique. Patients with a follow-up of less than 12 months were excluded from this study.

Results

Over a period of 10 years, 208 boys underwent primary surgical repair of non-proximal hypospadias. Eighty-nine of the 208 patients (42.8%) underwent single-stage hypospadias repair. Two-stage repair of the hypospadias was required in 119 (57.2%) of the patients. The overall complication rate was 3.4% in the group operated in a single stage and 7.6% in the group that required a two-stage repair (p = 0.09). The most frequent complication reported was urethrocutaneous fistula (p = 0.31), followed by meatal stenosis (p = 0.37), urethral stricture (p = 0.08) and wound dehiscence (p = 0.16). There was no significant difference between the complication rates of the two groups.

Conclusion

Patients with distal hypospadias and poor urethral plate characteristics repaired in a two-stage approach have comparable low-complications to those with favorable urethral plate characteristics repaired in a single-stage.
Electroacupuncture Reduces Anxiety Associated With Inflammatory Bowel Disease By Acting on Cannabinoid CB1 Receptors in the Ventral Hippocampus in Mice
Authors: Hu Xue-Fei , Zhang Hong , Yu Ling-Ling , Ge Wen-Qiang , Zhan-mu Ou-Yang , Li Yan-Zhen , Chen Chao , Hou Teng-Fei , Xiang Hong-Chun , Li Yuan-Heng , Su Yang-Shuai , Jing Xiang-Hong , Cao Jie , Pan Hui-Lin , He Wei , Li Man
Published: July 2022

The therapeutic effects of electroacupuncture (EA) on the comorbidity of visceral pain and anxiety in patients with inflammatory bowel disease (IBD) is well known. It has been known that the ventral hippocampus (vHPC) and the cannabinoid type 1 receptors (CB1R) are involved in regulating anxiety and pain. Therefore, in this study, we determined whether EA reduces visceral pain and IBD-induced anxiety via CB1R in the vHPC. We found that EA alleviated visceral hyperalgesia and anxiety in TNBS-treated IBD mice. EA reversed over-expression of CB1R in IBD mice and decreased the percentage of CB1R-expressed GABAergic neurons in the vHPC. Ablating CB1R of GABAergic neurons in the vHPC alleviated anxiety in TNBS-treated mice and mimicked the anxiolytic effect of EA. While ablating CB1R in glutamatergic neurons in the vHPC induced severe anxiety in wild type mice and inhibited the anxiolytic effect of EA. However, ablating CB1R in either GABAergic or glutamatergic neurons in the vHPC did not alter visceral pain. In conclusion, we found CB1R in both GABAergic neurons and glutamatergic neurons are involved in the inhibitory effect of EA on anxiety but not visceral pain in IBD mice. EA may exert anxiolytic effect via downregulating CB1R in GABAergic neurons and activating CB1R in glutamatergic neurons in the vHPC, thus reducing the release of glutamate and inhibiting the anxiety circuit related to vHPC. Thus, our study provides new information about the cellular and molecular mechanisms of the therapeutic effect of EA on anxiety induced by IBD.
Cascade Prediction With Self-Exciting Point Process and Local User Influence Measurement
Authors: Zhao Yingsi , Zhong Chu
Published: July 2022

With the rise and large-scale applications of social networking service, the prediction of information cascades has attracted extensive attention of researchers. User influence is an important factor affecting the dissemination of posts in online social networks. However, current studies usually take the number of users’ neighbors as their influence, and do not accurately describe the role of participating users in information dissemination. In this paper, a prediction model of information cascades in social networks is established based on the Hawkes process, and the model considers three factors, i.e., post influence, user influence and users’ response time, to describe the occurrence probability of forwarding events. In order to utilize abundant information of local network topology, we present a new method of calculating user influence, combining with semi-local centrality and local clustering coefficients. Then, a regression tree algorithm is used to determine time correction coefficients to reveal dynamic post influence, and the popularity prediction of posts in social networks is realized. Comparison experiments of different models are carried out on real-world datasets to evaluate the effectiveness and prediction performance of the proposed model, and results show that our method outperforms other counterparts.
A Quantum Predictive Brain: Complementarity Between Top-Down Predictions and Bottom-Up Evidence
Authors: Mastrogiorgio Antonio
Published: July 2022

Predictive brain theory challenges the general assumption of a brain extracting knowledge from sensations and considers the brain as an organ of inference, actively constructing explanations about reality beyond its sensory evidence. Predictive brain has been formalized through Bayesian updating, where top-down predictions are compared with bottom-up evidence. In this article, we propose a different approach to predictive brain based on quantum probability—we call it Quantum Predictive Brain (QPB). QPB is consistent with the Bayesian framework, but considers it as a special case. The tenet of QPB is that top-down predictions and bottom-up evidence are complementary, as they cannot be co-jointly determined to pursue a univocal model of brain functioning. QPB can account for several high-order cognitive phenomena (which are problematic in current predictive brain theories) and offers new insights into the mechanisms of neural reuse.
Mediating Role of Psychological Maladjustment in Relation Between Dark Triad, Psychological Distress and Subjective Happiness of Pakistani Emerging Adults
Authors: Mushtaq Asia , Inam Ayesha , Najmussaqib Arooj , Afshan Anjum , Ermagan-Caglar Eda
Published: July 2022

The transition from adolescence to adulthood is fraught with challenges that might have impacts on later life and personality development. Earlier research investigated Dark Triad traits in connection to emotional problems. The current study, on the other hand, focused on investigating the mediating role of psychological maladjustment in the relation of Dark Triad traits, psychological distress, and subjective happiness in emerging adults. A sample of 546 participants aged 18–25 years (M = 21.2 years) from Pakistan have participated to complete an online survey. Standardized assessment tools were used to measure the targeted variables. Results indicated that Machiavellianism and psychopathy were positively associated with psychological distress, whereas narcissism appeared to be a non-significant predictor. Subjective happiness was positively associated with Machiavellianism and negatively associated with psychopathy. In addition, mediation analysis through Structural Equation Modeling (SEM) indicated that the Dark Triad traits (Machiavellianism and psychopathology), psychological distress, and subjective wellbeing were explained by psychological maladjustment. Implications and limitations are discussed.
Changes in Affect Integration and Internalizing Symptoms After Time-Limited Intersubjective Child Psychotherapy—A Pilot Study
Authors: Fiskum Charlotte , Andersen Tonje G. , Johns Unni T. , Jacobsen Karl
Published: July 2022

Time-limited intersubjective child-psychotherapy (TIC) is an intensive, structured right-brain oriented therapeutic approach for children and caregivers aimed at both symptom reduction and strengthening core developmental processes such as affect integration. This is the first study to investigate changes in internalizing symptoms and affect integration after TIC. Thirty-three children between 9 and 13 years with internalizing difficulties were assessed after 10 h of TIC. Internalizing symptoms were assessed through the child behavior checklist and affect integration with the affect consciousness interview (ACI). Scores from the children with internalizing difficulties were modeled in a mixed linear model along with data from a control group without internalizing difficulties (n = 24) to control for effects of time and learning. Affect integration increased significantly from time 1 to time 2 in the children with internalizing problems, but not in the control children. Internalizing symptoms were also significantly reduced in the children with internalizing difficulties from time 1 to time 2. The results indicate that TIC may contribute to a decrease in symptoms along with an increase in affect integration in children with internalizing difficulties, making the children better able to notice, tolerate and communicate affective states. This can, in turn, aid development and day-to-day regulation and interactions. The article explores key elements of TIC, such as affective attunement, relational repair, and work with caregivers using one of the individual therapies in the study as an example. The article argues that TIC represents a right-hemisphere to right-hemisphere therapeutic approach to healing that can both enhance important common therapeutic factors such a relation and alliance and bring about growth-promoting change.
Private Kindergarten Teachers' Intention to Remain: A Comparison Between the Effects of Organizational and Individual Psychological Factors
Authors: Shi Song , Zhang Zizai , Wu Hotang , Zhang Xiaomei
Published: July 2022

The purpose of this study was 2-fold: to validate the Private Kindergarten Teachers' Intention of Remaining (PKTIR) Questionnaire and the Factors of Teachers' Intention of Remaining (FTIR) Questionnaire, and to comparative study to explore the effects of organizational and individual psychological factors in China. A total of 22 experts were recruited to modify and validate both questionnaires. The results showed that both questionnaires had instruments that are reliable and valid. Then, a total of 582 kindergarten teachers were recruited to explore the comparison between the effects of organizational and individual psychological factors. The results from the structural equation model suggested that the influence of individual psychological factors on kindergarten teachers' intention of remaining was greater compared to the organizational factors. Second, among all the factors, the most explanatory are work connections, sense of work gained from it, satisfaction with the salary, and work discard. To our knowledge, this is the first comparative study to explore the effects of organizational and individual psychological factors in China.
Developing a Conceptual Partner Matching Framework for Digital Green Innovation of Agricultural High-End Equipment Manufacturing System Toward Agriculture 5.0: A Novel Niche Field Model Combined With Fuzzy VIKOR
Authors: Yin Shi , Wang Yuexia , Xu Junfeng
Published: July 2022

Digital green innovation (DGI) is the core factor that affects the digitalization and decarbonization strategy of agricultural high-end equipment manufacturing (AHEM) system. Although AHEM enterprises actively cooperate with academic research institutes to develop agricultural high-end equipment, there are many obstacles in the process of DGI. Moreover, the integration of digital technology and green innovation from the perspective of partner matching for the AHEM system has not been fully introduced in current literature. Hence, this study aimed to (i) establish a suitable framework system for the AHEM system in general, (ii) quantify the selection of DGI by academic research institutions based on niche theory, and (iii) propose an extended niche field model combined with fuzzy VIKOR model. First, a theoretical framework consisting of three core elements of technology superposition, mutual benefit, and mutual trust, and technological complementarity was constructed based on niche intensity and niche overlap degree. DGI ability superposition of technology, mutual trust, and technical complementarity are beneficial for transferring DGI knowledge from academic research institutes to the AHEM industry. Second, triangle fuzzy number and prospect theory combined with the VIKOR method were introduced into the field theory to construct the complementary field model of DGI resources. The niche field model has been successfully applied to practical cases to illustrate how the model can be implemented to solve the problem of DGI partner selection. Third, the results of a case study show that the criteria framework and the niche field model can be applied to real-world partner selection for AHEM enterprises. This study not only puts forward the standard framework of niche fitness evaluation based on niche theory but also establishes the niche domain model of innovation partner selection management based on niche theory. The standard framework and novel niche field model can help enterprises to carry out digital green innovation in the development of high-end agricultural equipment. The study has the following theoretical and practical implications: (i) constructing a criteria framework based on niche theory; (ii) developing a novel niche field model for DGI partner selection of AHEM enterprises; and (iii) assisting AHEM enterprises to perform DGI practice.
On the Role of Chinese English as a Foreign Language: Teachers’ Well-Being and Loving Pedagogy in Their Academic Engagement
Authors: Li Bo , Miao Guoxin
Published: July 2022

Positive emotions are regarded as vital issues in English as a foreign language (EFL) instruction. This study attempted to consider the relationships between Chinese EFL teachers’ psychological well-being, loving Pedagogy, and work engagement as the constructs of positive psychology in academic contexts. It also tried to examine the contribution of psychological well-being and loving pedagogy in work engagement. To this end, 414 Chinese EFL teachers including participated in this study. The three questionnaires called Dispositions toward Loving Pedagogy Scale, Index of Psychological Well-Being at Work, and Self-report Engagement Questionnaire were distributed among learners. The findings showed significant relationships between well-being, loving pedagogy, and work engagement. Moreover, the results indicated that teachers’ psychological well-being significantly predicted their work engagement. This study provided some implications for teachers, teacher educators, and educational policy-makers to raise their awareness of adopting loving pedagogy and boosting teacher well-being for the enhancement of teacher involvement in academic contexts.
The Types of Learning Approaches Used by Engineering Students in Three Scenarios: An Adaptation of the R-SPQ-2F to China
Authors: Zhao Chunyu , Hou Haiyang , Gu Qiongying
Published: July 2022

Deep learning is a type of high-level learning that has received widespread attention in research on higher education; however, learning scenarios as an important variable have been ignored to some extent in past studies. This study aimed to explore the learning state of engineering students in three learning scenarios: theoretical learning, experimental learning, and engineering practice. Samples of engineering university students in China were recruited online and offline; the students filled in the engineering Education-Study Process Questionnaire, which was revised from the R-SPQ-2F. The results of clustering analysis showed four types of learning approaches in the three scenarios: typical deep learning, typical shallow learning, deep-shallow learning, and free learning. Engineering learners in different learning scenarios tended to adopt different learning approaches and showed gender differences. Due to factors such as differences in culture and choice of learning opportunities, the deep and shallow learners demonstrated excellent learning performance, which is in sharp contrast with the “learning failure” exhibited by such students abroad.
Gaming Disorder Seen Through the Prism of Dual Diagnosis: Prevalence and Associated Factors
Authors: Barrangou-Poueys-Darlas Malcolm , Cabelguen Clémence , Garrouste Vincent , Leboucher Juliette , Rocher Bruno , Challet-Bouju Gaëlle , Grall-Bronnec Marie
Published: July 2022

Introduction

Dual diagnosis (DD) is defined as the co-occurrence of at least a psychiatric disorder and at least an addictive disorder. Most studies about DD considered substance use disorders. In 2018, gaming disorder (GD) was recognized as a formal disorder and integrated into the category of addictive disorders in the 11th version of the International Classification of Diseases. Our objectives were to measure DD prevalence among GD patients and to assess factors associated with the presence of DD.

Methods

As part of the EVALuation of behavioral ADDictions (EVALADD) cohort, 92 patients with GD were included in the present study. Psychiatric disorders, including anxiety, mood, and psychotic disorders, were explored with the Mini International Neuropsychiatric Interview (MINI 5.0.0). Probable adult attention-deficit/hyperactivity disorder (ADHD) was screened with the Wender Utah Rating Scale (WURS) in childhood and with the ADHD Self-Report Scale-V1.1 (ASRS) in adulthood. Finally, personality was assessed using the 125-item version of the Temperament and Character Inventory (TCI-125), motives for gaming with the Videogame Motives Questionnaire (VMQ) and attachment styles with the Relationship Scales Questionnaire (RSQ). To measure the prevalence of DD among GD patients, we considered the occurrence of current GD with current anxiety, mood, or psychotic disorders, or with probable current ADHD. We also performed a multivariate analysis to identify independent factors associated with DD.

Results

More than half (55.4%) of GD patients suffered from DD. We found a high prevalence of probable ADHD (38%) and anxiety disorders (29% suffering from generalized anxiety disorder, social, agoraphobia or panic disorder). Four variables were significantly associated with DD: suicidal thoughts [odds ratio (OR) = 6.83, 95% confidence interval (95%CI) (1.66–28.09)], VMQ “coping” scores [OR = 1.18, 95%CI (1.01–1.38)], TCI-125 “harm avoidance” scores [OR = 1.04, 95%CI (1.01–1.07)] and “novelty seeking” scores [OR = 1.03, 95%CI (1.00–1.06)].

Discussion

The prevalence of certain psychiatric disorders among GD patients far exceeded that observed in the general population. Both ADHD and suicidal ideations should particularly be screened among GD patients. Specific interventions targeting personality dimensions associated with DD but also on the management of negative affect should represent new treatment opportunities.
HSF-1: Guardian of the Proteome Through Integration of Longevity Signals to the Proteostatic Network
Authors: Lazaro-Pena Maria I. , Ward Zachary C. , Yang Sifan , Strohm Alexandra , Merrill Alyssa K. , Soto Celia A. , Samuelson Andrew V.
Published: July 2022

Discoveries made in the nematode Caenorhabditis elegans revealed that aging is under genetic control. Since these transformative initial studies, C. elegans has become a premier model system for aging research. Critically, the genes, pathways, and processes that have fundamental roles in organismal aging are deeply conserved throughout evolution. This conservation has led to a wealth of knowledge regarding both the processes that influence aging and the identification of molecular and cellular hallmarks that play a causative role in the physiological decline of organisms. One key feature of age-associated decline is the failure of mechanisms that maintain proper function of the proteome (proteostasis). Here we highlight components of the proteostatic network that act to maintain the proteome and how this network integrates into major longevity signaling pathways. We focus in depth on the heat shock transcription factor 1 (HSF1), the central regulator of gene expression for proteins that maintain the cytosolic and nuclear proteomes, and a key effector of longevity signals.
Fast Joint Multi-Robot Trajectory Optimization by GPU Accelerated Batch Solution of Distributed Sub-Problems
Authors: Guhathakurta Dipanwita , Rastgar Fatemeh , Sharma M. Aditya , Krishna K. Madhava , Singh Arun Kumar
Published: July 2022

We present a joint multi-robot trajectory optimizer that can compute trajectories for tens of robots in aerial swarms within a small fraction of a second. The computational efficiency of our approach is built on breaking the per-iteration computation of the joint optimization into smaller, decoupled sub-problems and solving them in parallel through a custom batch optimizer. We show that each of the sub-problems can be reformulated to have a special Quadratic Programming structure, wherein the matrices are shared across all the problems and only the associated vector varies. As result, the batch solution update rule reduces to computing just large matrix vector products which can be trivially accelerated using GPUs. We validate our optimizer’s performance in difficult benchmark scenarios and compare it against existing state-of-the-art approaches. We demonstrate remarkable improvements in computation time its scaling with respect to the number of robots. Moreover, we also perform better in trajectory quality as measured by smoothness and arc-length metrics.
Enhancing Military Training Using Extended Reality: A Study of Military Tactics Comprehension
Authors: Boyce Michael W. , Thomson Robert H. , Cartwright Joel K. , Feltner David T. , Stainrod Cortnee R. , Flynn Jeremy , Ackermann Christian , Emezie John , Amburn Charles R , Rovira Ericka
Published: July 2022

This study identifies that increasing the fidelity of terrain representation does not necessarily increase overall understanding of the terrain in a simulated mission planning environment using the Battlefield Visualization and Interaction software (BVI; formerly known as ARES (M. W. Boyce et al., International Conference on Augmented Cognition, 2017, 411–422). Prior research by M. Boyce et al. (Military Psychology, 2019, 31(1), 45–59) compared human performance on a flat surface (tablet) versus topographically-shaped surface (BVI on a sand table integrated with top-down projection). Their results demonstrated that the topographically-shaped surface increased the perceived usability of the interface and reduced cognitive load relative to the flat interface, but did not affect overall task performance (i.e., accuracy and response time). The present study extends this work by adding BVI onto a Microsoft HoloLens™. A sample of 72 United States Military Academy cadets used BVI on three different technologies: a tablet, a sand table (a projection-based display onto a military sand table), and on the HoloLens™ in a within-subjects design. Participants answered questions regarding military tactics in the context of conducting an attack in complex terrain. While prior research (Dixon et al., Display Technologies and Applications for Defense, Security, and Avionics III, 2009, 7327) suggested that the full 3D visualization used by the Hololens™ should improve performance relative to the sand table and tablet, our results demonstrated that the HoloLens™ performed relatively worse than the other modalities in accuracy, response time, cognitive load, and usability. Implications and limitations of this work will be discussed.
Can the Right Crop Mix Reduce the Water Rebound Effect Following Improvements in Irrigation Efficiency?
Authors: Chai Ying , Zhang Haoran , Ma Zilong , Pan Su , Zhou Jieqi
Published: July 2022

Water rebound has been recognized as a significant issue that reduces the effectiveness of irrigation efficiency improvement policies aimed at water conservation. However, there is an absence of quantitative analysis of the impact of crop mixes on the water rebound effect, and studies focusing on the heterogeneous effects of various climatic regions are scarce. Thus, this study aims to explore the effects of water rebound on irrigation efficiency improvements from the perspectives of crop mix and climatic region. First, we construct a double-layered moderating effect framework to incorporate the two interactive factors of crop mix and climatic region combined with two rebound mechanisms, cost reduction and increased revenue. Second, we conduct empirical analyses to test three hypotheses based on provincial-level data from 2003 to 2017 in China, which provides a unique empirical context wherein changes in the crop mix depend on factors other than the water-use policy. This paper takes advantage of the implementation of Rural Land Contracting Law since 2003 and Water Conservancy Key Counties Construction Program since 2009 to identify the effects of water rebound on irrigation efficiency improvements from the perspectives of crop mix and climatic region. We found that the water rebound effect was about 67.72%. Crop mixes involving higher proportions of non-grain crops were associated with higher levels of water conservation and less water rebound. Furthermore, non-grain crops in humid regions were more likely to experience water rebound than those in non-humid regions. Thus, given China's national strategy of food security, reducing the proportion of non-grain crops in humid regions will help to sustain agricultural water resources and conserve the environment.
Leader Humility, Sense of Power, and Interpersonal Deviance Relationship Model in the Bureaucratic Culture
Authors: Hadmar Ambo Sakka , Hendryadi Hendryadi , Suratna Suratna , Karyatun Subur
Published: July 2022

Purpose

Drawing on the approach—inhibition theory of power and the containment theory of control—we propose a relationship model of leader humility, sense of power, and interpersonal deviance, by placing bureaucratic culture as a boundary condition.

Design/Methodology/Approach

Using a moderated mediation model, this study applies hierarchical regression and bootstrapping analyses to data obtained from online questionnaire responses of 428 employees from various sectors in Indonesia.

Findings

The results reveal a positive relationship between leader humility and employees perceptions of the sense of power, as well as between the sense of power to interpersonal deviance. In addition, we confirmed the mediating role of the sense of power on the relationship between leader humility and interpersonal deviant. Bureaucratic culture has been confirmed to moderate the relationship between a sense of power and interpersonal deviance.

Practical Implications

Companies can provide leadership training to leaders to convey to them when and where to demonstrate humility. Furthermore, the effectiveness of leaders' humility can be increased and their sense of power and interpersonal deviance reduced if the company adopts a low-level bureaucratic culture.

Originality/Value

The current study contributes to the extant literature by revealing the moderating effects of bureaucratic culture on the relationship between the sense of power and interpersonal deviance, clarifying how, and when employees' sense of power stimulates interpersonal deviance in the Asian context.
Molecular Precursors of the RNA-World in Space: New Nitriles in the G+0.693−0.027 Molecular Cloud
Authors: Rivilla Víctor M. , Jiménez-Serra Izaskun , Martín-Pintado Jesús , Colzi Laura , Tercero Belén , de Vicente Pablo , Zeng Shaoshan , Martín Sergio , García de la Concepción Juan , Bizzocchi Luca , Melosso Mattia , Rico-Villas Fernando , Requena-Torres Miguel A.
Published: July 2022

Nitriles play a key role as molecular precursors in prebiotic experiments based on the RNA-world scenario for the origin of life. These chemical compounds could have been partially delivered to the young Earth from extraterrestrial objects, stressing the importance of establishing the reservoir of nitriles in the interstellar medium. We report here the detection towards the molecular cloud G+0.693−0.027 of several nitriles, including cyanic acid (HOCN), and three C4H3N isomers (cyanoallene, CH2CCHCN; propargyl cyanide, HCCCH2CN; and cyanopropyne (CH3CCCN), and the tentative detections of cyanoformaldehyde (HCOCN), and glycolonitrile (HOCH2CN). We have also performed the first interstellar search of cyanoacetaldehyde (HCOCH2CN), which was not detected. Based on the derived molecular abundances of the different nitriles in G+0.693−0.027 and other interstellar sources, we have discussed their formation mechanisms in the ISM. We propose that the observed HOCN abundance in G+0.693−0.027 is mainly due to surface chemistry and subsequent shock-induced desorption, while HCOCN might be mainly formed through gas-phase chemistry. In the case of HOCH2CN, several grain-surface routes from abundant precursors could produce it. The derived abundances of the three C4H3N isomers in G+0.693−0.027 are very similar, and also similar to those previously reported in the dark cold cloud TMC-1. This suggests that the three isomers are likely formed through gas-phase chemistry from common precursors, possibly unsaturated hydrocarbons (CH3CCH and CH2CCH2) that react with the cyanide radical (CN). The rich nitrile feedstock found towards G+0.693−0.027 confirms that interstellar chemistry is able to synthesize in space molecular species that could drive the prebiotic chemistry of the RNA-world.
Examining the Eye Movement Behaviors Associated With Skilled Decision-Making by Elite Australian Rules Football Players
Authors: Kassem Lael , MacMahon Clare , Quinn John , Dogramaci Sera , Pang Bonnie , Steel Kylie A.
Published: July 2022

Exploration of eye-movement behaviors of humans can provide insight into the processes used to inform and make decisions, with a large body of research revealing general trends, especially in the sporting context. Despite this some questions remain within the sport context particularly for elite groups engaged in diverse sports, and the potential for this information to provide for training, development, and performance. Therefore, the purpose of this study was to examine the critical fixation points and durations associated with superior decision-making within an elite group of Australian Rules football players. To achieve this eye-movement behavior (fixations) and associated decision-making skills of (N = 27; Mage = 25.0 ± 3.7 yrs) elite Australian Rules (AR) football players were measured while they watched game-based video clips. The most skilled players made significantly faster decisions compared to less skilled players (p < 0.001), who also had significantly shorter total fixation duration (p < 0.0001). Further, analysis showed that the most skilled players spent more time fixating on potential options within an area of interest (p = 0.003). Thus, within a group of highly skilled group of athletes, distinctions can be made on perceptual-cognitive skills, for outcome decisions and decision processes. That is, skilled decision-makers appear to have more efficient visual search strategies, which may help them process visual information more effectively. Further, examination of these behaviors may aid sport science and coaching staff identify the process that can be refined to increase player ability between and within various teams.
“Atypical” Mild Clinical Presentation in Elderly Patients With Ruptured Intracranial Aneurysm: Causes and Clinical Characteristics
Authors: Wen Dingke , Chen Ruiqi , Zhang Tianjie , Li Hao , Zheng Jun , Fu Wei , You Chao , Ma Lu
Published: July 2022

Objective

Thunderclap-like severe headache or consciousness disturbance is the common “typical” clinical presentation after aneurysmal subarachnoid hemorrhage (aSAH); however, a slowly developing “atypical” clinical pattern, with mild headache, vomiting, or dizziness, is frequently noted in elderly patients. The aim of this study was to evaluate the clinical characteristics of this “atypical” subgroup, as well as related factors associated with the presence of these mild symptoms.

Methods

The data of 176 elderly patients (≥70 years old) with ruptured intracranial aneurysms (IAs) treated at our center from January 2016 to January 2020 were retrospectively collected and analyzed. The patients were divided into “typical” and “atypical” groups based on their initial and development of clinical symptoms after the diagnosis of aSAH. Intergroup differences were analyzed, and factors related to the presence of these two clinical patterns were explored through multiple logistic regression analyses.

Results

Despite significant admission delay (P < 0.001) caused by mild initial symptoms with slow development, patients in the “atypical” group achieved better clinical prognosis, as indicated by a significantly higher favourable outcome ratio and lower death rate upon discharge and at different time points during the 1-year follow-up, than the “typical” group (P < 0.05). Multiple logistic regression analysis revealed that modified Fisher grade III-IV (OR = 11.182, P = 0.003), brain atrophy (OR = 10.010, P = 0.001), a larger lesion diameter (OR = 1.287, P < 0.001) and current smoking (OR = 5.728, P < 0.001) were independently associated with the presence of “typical” symptoms. Aneurysms with wide necks (OR = 0.013, P < 0.001) were independently associated with the presence of “atypical” symptoms.

Conclusions

“Atypical” presentations, with mild clinical symptoms and slow development, were commonly recorded in elderly patients after the onset of aSAH. Despite the prolonged admission delay, these “atypical” patients achieved better clinical outcomes than those with “typical” symptoms. Modified Fisher grade (III-IV), current smoking, brain atrophy and larger lesion diameter were factors predictive of “typical” symptoms, while aneurysms with wide necks were independently associated with “atypical” symptoms.