bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of Point-of-Care Lactate Testing for Sepsis on Bundle Adherence and Clinical Outcomes in the Emergency Department: A Pre–Post Observational Study
Authors: Lee Sukyo , Song Juhyun , Lee Sungwoo , Kim Su Jin , Han Kap Su , Lee Sijin
Published: September 2024

Background: The early diagnosis and prompt treatment of sepsis can enhance clinical outcomes. This study aimed to assess the relationship between point-of-care testing (POCT) for lactate levels and both adherence to the Surviving Sepsis Campaign (SSC) guidelines and mortality rates among sepsis patients in the emergency department (ED). We hypothesized that bedside lactate POCT would lead to better clinical outcomes. Methods: We conducted a pre–post observational study utilizing data from a prospectively collected sepsis registry. Following the introduction of lactate POCT, lactate levels were determined using both the central laboratory pathway and a POCT device. We then compared the characteristics and clinical outcomes between the periods before and after the introduction of POCT lactate measurement. Results: The analysis included a total of 1191 patients. The introduction of bedside lactate POCT led to a significant reduction in the time taken to obtain lactate results (from 53 to 33 min) and an increase in the rate of subsequent lactate measurements (from 82.1% to 88.2%). Lactate POCT did not significantly affect adherence to the overall SSC guidelines bundle (47.5% vs. 45.0%) or reduce 30-day mortality rates (31.1% vs. 31.4%). However, bedside lactate POCT could decrease extremely delayed lactate measurements. Conclusions: Bedside lactate POCT successfully reduced the time to obtain lactate results. Although lactate POCT did not lead to improved adherence to the overall SSC guidelines bundle or affect short-term mortality rates in sepsis patients, it may have an advantage in a specific situation such as overcrowded ED where there are subsequent or multiple measurements required.
Gait, Quality of Life, and Knee Function in Advanced Knee Osteoarthritis: A Single-Center, Prospective, Observational Study
Authors: Freijo Valentín , Navarro Claudia , Villalba Jordi
Published: September 2024

Background/Objectives: Treatment of advanced knee osteoarthritis with total knee arthroplasty typically results in an improvement in function, gait, and quality of life, which tend to be affected by the condition. It is, however, necessary to determine the baseline factors that could influence the patients’ postoperative outcome. Methods: This is a single-center prospective observational study of patients with advanced knee osteoarthritis (Kellgren–Lawrence grade 3 or 4) treated with total knee arthroplasty. Gait parameters were recorded at baseline and at various postoperative time points using a wireless device. Progression of function was assessed using the Knee Society Score questionnaire and quality of life by means of the EQ-5D and Knee Injury and Osteoarthritis Outcome Score questionnaires. Progression of gait and quality of life was analyzed in all patients, distinguishing between those where baseline velocity was < 1 m/s and those where it was ≥1 m/s. The potential correlation between baseline and postoperative parameters was also evaluated. Results: All 119 patients showed a significant improvement in their gait, function, and quality of life parameters at one year from the procedure (p < 0.05). No statistically significant differences were found in any of the postoperative subscales, regardless of baseline velocity (< o ≥ 1 m/s) or between any of the baseline or postoperative parameters (r < 0.29). Conclusions: Baseline gait parameters in patients with advanced knee osteoarthritis do not appear to bear a statistically significant relationship with function or quality of life outcomes following total knee arthroplasty. Such parameters exhibit a significant improvement one year after surgery.
The Effect of Photobiomodulation on Third Molar Wound Recovery: A Systematic Review with Meta-Analysis
Authors: Giansiracusa Aldo , Parrini Stefano , Baldini Nicola , Bartali Elena , Chisci Glauco
Published: September 2024

Objectives: This study addresses the limited body of literature concerning the impact of photobiomodulation on complications following mandibular third molar extractions. Methods: A systematic literature review and meta-analysis of clinical studies that reported the use of photobiomodulation after mandibular third molar surgery was conducted based on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) recommendations. The formulation of research questions followed the PICO model, and comprehensive strategies for record search and study selection were devised. The protocol was registered on PROSPERO (The Prospective Register of Systematic Reviews; no CRD42024511892). Two independent reviewers consulted four databases during the literature search: MEDLINE/PubMed, Google Scholar, Clinicaltrial.gov, and Cochrane Library databases without imposing any date restrictions. A search on the grey literature was carried out too (OpenGrey). Duplicate articles were eliminated. Results: After the initial screening, 18 studies were retained to be screened by the reviewers. The full texts of the identified studies were scrutinized for original data, and their related references were manually retrieved and checked for additional relevant studies. The available studies exhibit considerable heterogeneity, exploring various factors related to postoperative outcomes. Our meta-analysis primarily focuses on three key aspects: the incidence of alveolar osteitis (AO), mucosa repair/alveolar pocket healing, and bone repair. The resultant CI of the VAS scale was 98 to 99%. Conclusions: This meta-analysis underscores the need for further research in this domain, highlighting the existing heterogeneity among studies and the importance of a nuanced understanding of photobiomodulation’s multifaceted effects on postoperative complications.
The Role of Thalidomide and Its Analogs in the Treatment of Hereditary Hemorrhagic Telangiectasia: A Systematic Review
Authors: Ugur Mehmet Can , Baysal Mehmet , Umit Elif Gulsum
Published: September 2024

Background: Hereditary hemorrhagic telangiectasia (HHT) is a disease characterized by arteriovenous malformations and telangiectases, in which the endothelium and immune system play a role in the pathophysiology. Therefore, treatments with antiangiogenic properties which are also regarded as immunomodulators were demonstrated to play an important role in treatment. This systematic review aimed to gather the accumulated information of the use of thalidomide and its analogs in the treatment of HHT. Methods: In this systematic review, publications that were published up to March 2024 and met the inclusion criteria were compiled using the keywords ‘thalidomide’, ‘lenalidomide’, ‘pomalidomide’, ‘immunomodulatory drugs’ and ‘HHT’ in Medline and Scholars databases. Results: A total of 53 articles were evaluated and 15 were included in the study. Thalidomide was the predominant used agent and was observed to be used in patients with ages ranging from 37 to 77 years, with doses ranging from 50 to 200 mg daily, and the mean follow-up period was observed to be 6–60 months. Assessments regarding efficacy were based on the epistaxis severity score (ESS), hemoglobin level, and transfusion independence. While thalidomide showed significant efficacy, it also had an adverse event rate of any severity of up to 85% of patients. Use of lenalidomide to control bleeding in HHT was reported in a single case report, while the use of pomalidomide was observed to be investigated in Phase 1 and Phase 2 studies in patients aged 48 to 70 years, with doses ranging from 1 to 5 mg daily for 6–24 months. This treatment was reported to provide significant improvement in hemoglobin levels and ESS. Adverse events of any severity were observed at a frequency of 60–66%. Conclusions: Antiangiogenic agents such as thalidomide, lenalidomide, and pomalidomide may be effective in managing HHT. However, further studies are needed to optimize the timing, dose, and sequence.
Zero-Contrast Transcatheter Aortic Valve Implantation vs. Standard Practice: Periprocedural and Long-Term Clinical Outcomes
Authors: Nerla Roberto , Mikus Elisa , Sanseviero Angela , Squeri Angelo , Calvi Simone , Savini Carlo , Sangiorgi Diego , Castriota Fausto
Published: September 2024

Background: We aimed to compare the procedural efficacy and long-term clinical results of a totally contrast-free Transcatheter Aortic Valve Implantation (TAVI) procedure (i.e., contrast dye was not used for either the pre-procedural assessment or during the procedure) to those of standard practice in patients with severe renal dysfunction. Methods: All consecutive patients with a glomerular filtration rate (GFR) ≤ 35 mL/min and severe aortic stenosis who were treated with transfemoral TAVI at our Institution were included in the registry. The zero-contrast patients underwent carbon dioxide angiography and a non-contrast CT scan for assessment of vascular access suitability, and aortic annulus sizing was performed by a TEE, and the procedural guidance was fluoroscopic and echocardiographic. Procedural outcomes were evaluated, and clinical long-term follow-up was performed for all included patients. Results: A total of 44 patients (median age, 85 (IQR, 80.75–87.00)) were included in the zero-contrast group (TEE guidance and general anesthesia in 37 (84%) patients), while 63 patients were included in the standard practice arm (82 ± 78 mL of contrast dye used). Procedural success was obtained in 100% of cases. There were no differences in procedural outcomes, including final mean aortic gradients (5.5 (IQR, 5.0–10.0) mmHg in the zero-contrast group vs. 6.0 (IQR, 5.0–10.0) mmHg in the standard practice group) and rate of at least a moderate paravalvular leak (0% vs. 1.6% in the zero-contrast and standard practice groups, respectively; p = 0.31). No differences in AKI during the hospital stay were observed. Over a median follow-up of 3.3 years, there was a significantly lower rate of AKI (1.2% vs. 25.9%, p < 0.001) and rehospitalizations (1.6% vs. 35.5%, p < 0.00) in standard practice group. Conclusions: We showed for the first time the feasibility and efficacy of a totally contrast-free strategy compared to standard practice in TAVI patients with severe renal dysfunction. Besides achieving comparable procedural results, the zero-contrast strategy showed a better long-term clinical outcome in reducing hospital readmissions for kidney function deterioration.
The Role of Sodium Glucose Co-Transporter 2 Inhibitors in Atrial Fibrillation: A Comprehensive Review
Authors: Stachteas Panagiotis , Nasoufidou Athina , Karagiannidis Efstratios , Patoulias Dimitrios , Karakasis Paschalis , Alexiou Sophia , Samaras Athanasios , Zormpas Georgios , Stavropoulos George , Tsalikakis Dimitrios , Kassimis George , Papadopoulos Christodoulos , Fragakis Nikolaos
Published: September 2024

Atrial fibrillation (AF) is the most prevalent arrhythmia among adults worldwide, frequently co-occurring with comorbidities such as Heart Failure (HF) and Type 2 Diabetes Mellitus (T2DM). This association contributes to increased morbidity and mortality, elevated healthcare costs, and diminished quality of life. Consequently, preventing or delaying the onset and recurrence of AF is crucial for reducing the incidence of complications. Sodium-glucose cotransporter 2 inhibitors (SGLT2is), due to their multifaceted pharmacological actions, have been proposed as potential therapeutic agents in the management of AF. However, current evidence from both animal models and clinical studies remains inconclusive. This narrative literature review aims to provide a comprehensive analysis of existing evidence on the impact of SGLT2is on the prevalence, incidence of new-onset, and recurrence of AF in diabetic populations and patients with HF. Numerous observational studies, predominantly retrospective, suggest a consistent reduction in AF risk with SGLT2is, while randomized controlled trials (RCTs) have yielded mixed results, with some demonstrating benefits and others not reaching statistical significance. The heterogeneity in study outcomes, population characteristics, follow-up duration, and specific SGLT2is used, as well as potential biases, underscore the need for further extensive and rigorous RCTs to establish definitive conclusions and elucidate the underlying mechanisms.
Early and Mid-Term Results of Endovascular Aneurysm Repair with the Cordis Incraft Ultra-Low Profile Endograft: A High-Volume Center Experience
Authors: Baccani Luigi , Parlani Gianbattista , Isernia Giacomo , Lenti Massimo , Terpin Andrea Maria , Simonte Gioele
Published: September 2024

Background/Objectives: In recent years, manufacturers have developed new low-profile stent grafts to allow endovascular treatment of abdominal aortic aneurysms (AAA) in patients with small access vessels. We evaluated the early and mid-term outcomes of the Incraft (Cordis Corp, Bridgewater, NJ, USA) ultra-low profile endograft implantation in a high-volume single center. Methods: Between 2014 and 2023, 133 consecutive endovascular aneurysm repair (EVAR) procedures performed using the Incraft endograft were recorded in a prospective database. Indications included infrarenal aortic aneurysms, common iliac aneurysms, and infrarenal penetrating aortic ulcers. Mid-term results were analyzed using the Kaplan–Meier method. Results: During the study period, 133 patients were treated with the Cordis Incraft endograft, in both elective and urgent settings. The Incraft graft was the first choice for patients with hostile iliac accesses, a feature characterizing at least one side in 90.2% of the patients in the study cohort. The immediate technical success rate was 78.2%. The intraoperative endoleak rate was 51.9% (20.3% type 1 A, 0.8% type 1 B, and 30.8% type 2 endoleak). Within 30 days, technical and clinical success rates were both 99.3%; all type 1A and 1B endoleaks were resolved at the 30-day follow-up CT-angiogram. After a mean follow-up of 35.4 months, the actuarial freedom from the re-intervention rate was 96.0%, 91.1%, and 84.0% at 1, 3, and 5 years, respectively. The iliac leg patency rate was 97.1%, 94.1%, and 93.1% at 1, 3, and 5 years, respectively. No statistically significant differences were observed between hostile and non-hostile access groups, nor between the groups with grade 1, grade 2, and grade 3 access hostility. Conclusions: The ultra-low profile Cordis Incraft endograft represents a valid option for the endovascular treatment of AAA in patients with hostile iliac accesses. The procedure can be performed with high rates of technical and clinical success at 30 days and the rates of iliac branch occlusion observed during the follow-up period appear acceptable in patients with poor aorto-iliac outflow.
Single-Shot Ultra-Widefield Polarization-Diversity Optical Coherence Tomography for Assessing Retinal and Choroidal Pathologies
Authors: Tse Tiffany , Jung Hoyoung , Shahidul Islam Mohammad , Song Jun , Soo Grace , Abbas Khaldon , Ni Shuibin , Sumita Fernando , Paton Katherine , Miao Yusi , Jian Yifan , Mammo Zaid , Navajas Eduardo V. , Ju Myeong Jin
Published: September 2024

Background: Optical coherence tomography (OCT) is a leading ocular imaging modality, known for delivering high-resolution volumetric morphological images. However, conventional OCT systems are limited by their narrow field-of-view (FOV) and their reliance on scattering contrast, lacking molecular specificity. Methods: To address these limitations, we developed a custom-built 105∘ ultra-widefield polarization-diversity OCT (UWF PD-OCT) system for assessing various retinal and choroidal conditions, which is particularly advantageous for visualizing peripheral retinal abnormalities. Patients with peripheral lesions or pigmentary changes were imaged using the UWF PD-OCT to evaluate the system’s diagnostic capabilities. Comparisons were made with conventional swept-source OCT and other standard clinical imaging modalities to highlight the benefits of depolarization contrast for identifying pathological changes. Results: The molecular-specific contrast offered by UWF PD-OCT enhanced the detection of disease-specific features, particularly in the peripheral retina, by capturing melanin distribution and pigmentary changes in a single shot. This detailed visualization allows clinicians to monitor disease progression with greater precision, offering more accurate insights into retinal and choroidal pathologies. Conclusions: Integrating UWF PD-OCT into clinical practice represents a major advancement in ocular imaging, enabling comprehensive views of retinal pathologies that are difficult to capture with current modalities. This technology holds great potential to transform the diagnosis and management of retinal and choroidal diseases by providing unique insights into peripheral retinal abnormalities and melanin-specific changes, critical for early detection and timely intervention.
Clinical Characteristics of Distinct Subgroups of Patients with Primary Sjögren’s Syndrome Classified by Serological Profiles: A Comparison Study
Authors: Bodakçi Erdal
Published: September 2024

Sjögren’s syndrome (SS) is an autoimmune disease characterized by heterogeneous clinical presentation and the presence of various autoantibodies. This study aimed to determine the differences in clinical findings according to antibody positivity in patients with primary Sjögren syndrome (pSS) in the Turkish population. A retrospective study was conducted and 402 patients (378 women and 24 men) with pSS were analyzed. The patients were categorized into three subgroups based on serological tests. These were (1) quadruple seropositivity (positive for anti-Sjögren’s syndrome-related antigen A antibodies (anti-SSA; anti-Ro) and anti-Sjögren’s syndrome-related antigen B antibodies (anti-SSB; anti-La), rheumatoid factor (RF), and antinuclear antibody (ANA); (2) double seropositivity (positive for ANA and anti-SSA/Ro antibodies); and (3) quadruple seronegativity (negative for ANA, RF, anti-SSA/Ro and anti-SSB/La antibodies). The number of quadruple-seropositive patients was 72 (18.6%), double-seropositive 174 (43.2%), and quadruple-seronegative was 85 (21.1%). The age at diagnosis of quadruple-seropositive pSS was 42.4 ± 10.8, which was significantly younger than that of patients with double-seropositive and quadruple-seronegative pSS (p = 0.021, p = 0.112). In terms of organ involvement, salivary gland enlargement, arthralgia, arthritis, Raynaud’s phenomenon, lymphadenopathy, cutaneous vasculitis, interstitial lung disease, neurological involvement, autoimmune thyroiditis, renal interstitial disease, anemia, leukopenia, hypergammaglobulinemia, and hypocomplementemia were more common in quadruple-seropositive patients with pSS than in quadruple-seronegative patients (p < 0.0001). The results of this study confirmed the strong impact of immunological markers on the pSS phenotype at the time of diagnosis. Immunological patterns play a central role in the phenotypic expression of the disease, even during the initial diagnostic phase, and can guide physicians in designing personalized treatment plans for patients with pSS.
Research on the Spatial-Temporal Evolution of Changsha’s Surface Urban Heat Island from the Perspective of Local Climate Zones
Authors: Xiang Yanfen , Zheng Bohong , Wang Jiren , Gong Jiajun , Zheng Jian
Published: September 2024

Optimizing urban spatial morphology is one of the most effective methods for improving the urban thermal environment. Some studies have used the local climate zones (LCZ) classification system to examine the relationship between urban spatial morphology and Surface Urban Heat Islands (SUHIs). However, these studies often rely on single-time-point data, failing to consider the changes in urban space and the time-series LCZ mapping relationships. This study utilized remote sensing data from Landsat 5, 7, and 8–9 to retrieve land surface temperatures in Changsha from 2005 to 2020 using the Mono-Window Algorithm. The spatial-temporal evolution of the LCZ and the Surface Urban Heat Island Intensity (SUHII) was then examined and analyzed. This study aims to (1) propose a localized, long-time LCZ mapping method, (2) investigate the spatial-temporal relationship between the LCZ and the SUHII, and (3) develop a more convenient SUHI assessment method for urban planning and design. The results showed that the spatial-temporal evolution of the LCZ reflects the sequence of urban expansion. In terms of quantity, the number of built-type LCZs maintaining their original types is low, with each undergoing at least one type change. The open LCZs increased the most, followed by the sparse and the composite LCZs. Spatially, the LCZs experience reverse transitions due to urban expansion and quality improvements in central urban areas. Seasonal changes in the LCZ types and the SUHI vary, with differences not only among the LCZ types but also in building heights within the same type. The relative importance of the LCZ parameters also differs between seasons. The SUHI model constructed using Boosted Regression Trees (BRT) demonstrated high predictive accuracy, with R2 values of 0.911 for summer and 0.777 for winter. In practical case validation, the model explained 97.86% of the data for summer and 96.77% for winter. This study provides evidence-based planning recommendations to mitigate urban heat and create a comfortable built environment.
Interpreting Diastolic Dynamics and Evaluation through Echocardiography
Authors: Zhang Xiaoxiao , Li Ke , Cardoso Cristiano , Moctezuma-Ramirez Angel , Elgalad Abdelmotagaly
Published: September 2024

In patients with heart failure, evaluating left ventricular (LV) diastolic function is vital, offering crucial insights into hemodynamic impact and prognostic accuracy. Echocardiography remains the primary imaging modality for diastolic function assessment, and using it effectively requires a profound understanding of the underlying pathology. This review covers four main topics: first, the fundamental driving forces behind each phase of normal diastolic dynamics, along with the physiological basis of two widely used echocardiographic assessment parameters, E/e’ and mitral annulus early diastolic velocity (e’); second, the intricate functional relationship between the left atrium and LV in patients with varying degrees of LV diastolic dysfunction (LVDD); third, the role of stress echocardiography in diagnosing LVDD and the significance of echocardiographic parameter changes; and fourth, the clinical utility of evaluating diastolic function from echocardiography images across diverse cardiovascular care areas.
Obesity and Environmental Risk Factors Significantly Modify the Association between Ischemic Stroke and the Hero Chaperone C19orf53
Authors: Shilenok Irina , Kobzeva Ksenia , Deykin Alexey , Pokrovsky Vladimir , Patrakhanov Evgeny , Bushueva Olga
Published: September 2024

The unique chaperone-like properties of C19orf53, discovered in 2020 as a “hero” protein, make it an intriguing subject for research in relation to ischemic stroke (IS). Our pilot study aimed to investigate whether C19orf53 SNPs are associated with IS. DNA samples from 2138 Russian subjects (947 IS and 1308 controls) were genotyped for 7 C19orf53 SNPs using probe-based PCR. Dominant (D), recessive (R), and log-additive (A) regression models in relation to the effect alleles (EA) were used to interpret associations. An increased risk of IS was associated with rs10104 (EA G; Pbonf(R) = 0.0009; Pbonf(A) = 0.0004), rs11666524 (EA A; Pbonf(R) = 0.003; Pbonf(A) = 0.02), rs346158 (EA C; Pbonf(R) = 0.006; Pbonf(A) = 0.045), and rs2277947 (EA A; Pbonf(R) = 0.002; Pbonf(A) = 0.01) in patients with obesity; with rs11666524 (EA A; Pbonf(R) = 0.02), rs346157 (EA G; Pbonf(R) = 0.036), rs346158 (EA C; Pbonf(R) = 0.005), and rs2277947 (EA A; Pbonf(R) = 0.02) in patients with low fruit and vegetable intake; and with rs10104 (EA G; Pbonf(R) = 0.03) and rs11666524 (EA A; Pbonf(R) = 0.048) in patients with low physical activity. In conclusion, our pilot study provides comprehensive genetic and bioinformatic evidence of the involvement of C19orf53 in IS risk.
Inferential Interpretations of Many-Valued Logics
Authors: Molick Sanderson
Published: September 2024

Non-Tarskian interpretations of many-valued logics have been widely explored in the logic literature. The development of non-tarskian conceptions of logical consequence set the theoretical foundations for rediscovering well-known (Tarskian) many-valued logics. One may find in distinct authors many novel interpretations of many-valued systems. They are produced through a type of procedure which consists in altering the semantic structure of Tarskian many-valued logics in order to output a non-Tarskian interpretation of these logics. Through this type of transformation the paper explores a uniform way of transforming finitely many-valued Tarskian logics into their non-Tarskian interpretation. Some general properties of carrying out this type of procedure are studied, namely the dualities between these logics and the conditions under which negation-explosive and negation-complete Tarskian logics become non-explosive.
Investigation on the Dynamic Characteristics of a New High-Pressure Water Hydraulic Flow Control Valve
Authors: Liu Wenchao , Tian Jie , Wang Hongyao , Li Junshi , Zhou Rulin , Cao Yu
Published: September 2024

Water has the disadvantages of low viscosity, poor lubrication, and easy leakage, which leads to many problems in water hydraulic flow control valves, such as low working pressure and large flow fluctuations. To address these issues, this paper proposes a novel digital flow control valve. The valve uses a linear stepper motor as the driving device. Compared to proportional electromagnets, the thrust and stroke of the linear stepper motor are larger, making the valve more suitable for high-pressure working conditions. Simultaneously, the valve innovatively incorporates a set of pilot valve spool strings at the front end of the pilot valve damping hole. Through controlling the two pilot valves to regulate the pressure difference before and after the damping hole, the flow passing through the pilot valve is maintained stable, thereby making the pressure of the upper chamber of the master valve spool more stable. In comparison to a single pilot valve structure, this design ensures a more stable main valve core position and reduces flow fluctuation. A mathematical and simulation model of the valve has been established, confirming the performance advantages of the new structure. The impact of structural parameters (such as valve core diameter, spring stiffness, and diameter of damping hole) on the stability of flow regulation has been investigated. A genetic algorithm has been employed to optimize the key parameters that influence valve flow stability, resulting in the identification of optimal parameters. The simulation results indicate that the optimized parameters lead to a reduction of approximately 45% in the maximum overshoot oscillation amplitude of the valve flow regulation. A prototype of the new flow control valve was developed, and a test system was established for conducting tests. The test results also confirmed the performance advantages of the valve and the accuracy of the optimal design.
State Estimators for Plants Implementing ILC Strategies through Delay Links
Authors: Si Lina , Guo Xinyang , Huang Lixun , Zhang Qiuwen
Published: September 2024

Random delays in the communication links affect the precise tracking of the expected trajectory by a plant controlled by the iterative learning control (ILC) strategy. To tackle the link impact, this paper proposes a state estimator to derive accurate plant outputs that are necessary for controller learning. First, a data pre-processing method is designed to ensure that both the controller and actuator ends receive only one piece of data at any given moment. Subsequently, the data pre-processing method and the system information are used according to the theory of orthogonality to construct the state estimator. The simulation examples demonstrate that the developed estimators aid in the precise tracking of the desired trajectory by the plant implementing ILC strategies through delay links.
Improved Bounds for the Euclidean Numerical Radius of Operator Pairs in Hilbert Spaces
Authors: Altwaijry Najla , Sever Dragomir Silvestru , Feki Kais
Published: September 2024

This paper presents new lower and upper bounds for the Euclidean numerical radius of operator pairs in Hilbert spaces, demonstrating improvements over recent results by other authors. Additionally, we derive new inequalities for the numerical radius and the Davis–Wielandt radius as natural consequences of our findings.
Inverse Relations for Blossoms and Parametrisations of Rational Curves and Surfaces
Authors: Fernández-Jambrina Leonardo
Published: September 2024

In this paper, we make use of an inverse formula that relates the blossom of a NURBS curve, surface or Bézier triangle with its parametrisation, with no explicit reference to the control points and weights of the parametrisation. We make use of this inverse formula to raise and lower the degree elevation and reduction.
Review of the Use of Metals in Biomedical Applications: Biocompatibility, Additive Manufacturing Technologies, and Standards and Regulations
Authors: Ladani Leila , Palmieri Michael
Published: September 2024

Advanced manufacturing techniques such as Additive Manufacturing (AM) have grown rapidly in major industries such as aerospace, automotive, and biomedical device manufacturing. Biomedical industry has benefitted immensely from AM because of its flexibility in design and its rapid production cycle. Powder bed processes are the major production technique for metal-based AM implants. This paper serves as a comprehensive review on the research efforts being made using AM to develop new patient centered medical devices. This review focuses on AM of the most common metals for biomedical applications, Magnesium alloys, Cobalt-Chromium alloys, pure Titanium, Titanium alloys. Several different aspects are discussed including biocompatibility and osseointegration, application of specific metals in different types of implants, their advantages and disadvantages, mechanical properties in comparison to bone, and their production technologies. Regulatory and quality assurance hurdles that are facing new innovations made using AM are discussed.
Benzo[d]oxazoles from Anilides by N-Deprotonation–O-SNAr Cyclization
Authors: Nevels Nash E. , Subera Luke , Bunce Richard A.
Published: September 2024

A synthesis of benzo[d]oxazoles by an N-deprotonation–O-SNAr cyclization sequence from anilide precursors is reported. Anilides derived from 2-fluorobenzaldehydes, activated toward SNAr ring closure by C5 electron-withdrawing groups, were prepared and subjected to deprotonation–cyclization using 2 equiv. of K2CO3 in anhydrous DMF. Following deprotonation at nitrogen, the delocalized anion cyclized from the amide oxygen to give high yields of benzo[d]oxazoles. The temperature required for the cyclization of benzanilides correlated with the potency of the C5 activating group on the SNAr acceptor ring with nitro (most potent) reacting at 90 °C (1 h), cyano reacting at 115 °C (1 h), methoxycarbonyl reacting at 120 °C (2 h), and trifluoromethyl (least potent) reacting at 130 °C (3 h). Acetanilides were more difficult to cyclize but generally required 4–6 h at these same temperatures for completion. Product purification was accomplished by recrystallization or chromatography.
Fabrication of Active Z-Scheme Sr2MgSi2O7: Eu2+, Dy3+/COF Photocatalyst for Round-the-Clock Efficient Removal of Total Cr
Authors: Xu Meng , Wu Junshu , Zheng Mupeng , Wang Jinshu
Published: September 2024

Photoreduction is recognized as a desirable treatment method for hexavalent chromium (Cr(VI)). However, it has been limited by the intermittent solar flux and limited light absorption. In this work, a novel Z-scheme photocatalyst combining a covalent organic framework (COF) with Eu2+, Dy3+ co-doped Sr2MgSi2O7 (Sr2MgSi2O7:Eu2+, Dy3+) is synthesized, which shows the high spectral conversion efficiency and works efficiently in both light irradiation and dark for Cr(VI) reduction. Sr2MgSi2O7:Eu2+, Dy3+ serves as both an electron transfer station and active sites for COF molecule activation, thus resulting in 100% photoreduction of Cr(VI) (50 mL, 10 mg/L) with high light stability and over 1 h dark activity. Moreover, the XPS and FT-IR analyses reveal the existence of functional groups (Si-OH on Sr2MgSi2O7:Eu2+, Dy3+, and -NH- on COFTP-TTA) on the composited catalyst as active sites to adsorb the resultant Cr(III) species, demonstrating a synergistic effect for total Cr removal. This work provides an alternative method for the design of a round-the-clock photocatalyst for Cr(VI) reduction, allowing a versatile solid surface activation for establishing a more energy efficient and robust photocatalysis process for Cr pollution cleaning.
Research Progress of Fluorescent Probes for Detection of Glutathione (GSH): Fluorophore, Photophysical Properties, Biological Applications
Authors: Wang Yao , Li Yanfei , Cao Jinbo , Yang Xiyan , Huang Jiaxiang , Huang Mingyue , Gu Shaobin
Published: September 2024

Intracellular biothiols, including cysteine (Cys), glutathione (GSH), and homocysteine (Hcy), play a critical role in many physiological and pathological processes. Among them, GSH is the most abundant non-protein mercaptan (1–10 mM) in cells, and the change in GSH concentration level is closely related to the occurrence of many diseases, such as Parkinson’s disease, Alzheimer’s disease, and neurological diseases. Fluorescent probes have attracted much attention due to their advantages of high specificity, high sensitivity, high selectivity, low cost, and high quantum yield. Methods that use optical probes for selective detection of GSH in vitro and in vivo are in high demand. In this paper, we reviewed the most recent five years of research on fluorescence probes for the detection of GSH, including the specific detection of GSH, dual-channel identification of GSH and other substances, and the detection of GSH and other biothiols. According to the type of fluorophore, we classified GSH fluorescent probes into eight classes, including BODIPY, 1,8-Naphthalimide, coumarin, xanthene, rhodamine, cyanine, benzothiazoles, and others. In addition, we roundly discuss the synthesis, detection mechanism, photophysical properties, and biological applications of fluorescent probes. We hope that this review will inspire the exploration of new fluorescent probes for GSH and other related analyses.
Sensory Processing Challenges in Children with Neurodevelopmental Disorders and Genetic Conditions: An Observational Study
Authors: Rodríguez-Armendariz Ekaine , Vela-Romero María , Galiana Adrián
Published: September 2024

Sensory processing challenges are crucial yet often neglected aspects in the care of children with neurodevelopmental disorders and genetic conditions. They represent a key area of interest in neuroscience, as they significantly impact children’s daily functioning and quality of life. This observational study examines these challenges in a group of 614 children, aged 3 to 14 years and 11 months, divided into three groups: 183 with neurodevelopmental disorders (autism spectrum disorder, attention deficit hyperactivity disorder, developmental delays, and learning disorders), 89 with genetic conditions (22q11.2 deletion syndrome, Williams syndrome, and pseudohypoparathyroidism), and 342 controls. Sensory processing was assessed using Sensory Profile 2 (SP2). Results indicated that children with neurodevelopmental disorders and genetic conditions exhibited significant sensory processing difficulties compared to controls. SP2 identified distinct sensory challenges across different sensory systems, varying by diagnosis. Notably, genetic conditions appeared to have a more generalised impact across multiple sensory systems, while neurodevelopmental disorders tended to affect specific systems more narrowly. These findings highlight the importance of early identification and tailored evidence-based interventions to address these specific sensory processing issues. Further research should explore the long-term impact of these interventions in these different populations and their integration into broader therapeutic programmes.
Cyanobacterial Pigments as Natural Photosensitizers for Dye-Sensitized Solar Cells
Authors: Montagni Tatiana , Ávila Mauricio , Fernández Sofía , Bonilla Sylvia , Cerdá María Fernanda
Published: September 2024

Three filamentous freshwater cyanobacterial strains were grown at high light intensity to produce lipidic dyes composed of xanthophylls, carotenes, and chlorophyll a. The properties of the pigments were evaluated as suitable natural compounds to be applied in dye-sensitized solar cells (DSSC). The assembled DSSC were characterized using the density current vs. potential profiles and electrochemical impedance spectroscopy. With an efficiency of 0.127%, our results are higher than those previously reported using similarly structured compounds from natural sources such as algae and cyanobacteria, among others. The best efficiencies were probably related to myxoxanthophyll-like derivates and aphanizophyll are carotenoids with many hydroxyl groups being able to interact with the semiconductor surface. The stability of the bonding between the dyes and the titanium oxide of the photoelectrode is crucial to ensuring the acceptable performance of the DSSC, which was successfully achieved in our experiments with carotenoids with many hydroxyl groups. Our results point to cyanobacterial pigments as a promising source of natural dyes for use in solar cells.
Research on Erosion Damage Laws and Structural Optimization of Bypass Valve for Positive Displacement Motors
Authors: Zhang Yanbo , Zhang Lei , Gao Yulin , Shi Ping , Wang Yu , Kong Lingrong
Published: September 2024

The bypass valve of a positive displacement motor is a key component for regulating the bottom hole pressure and ensuring the normal circulation of drilling fluid during the drilling process. Severe erosion damage to the bypass valve significantly affects the service life of the positive displacement motor, yet there is currently a lack of related research. In this research, the flow characteristics of drilling fluid inside the valve core were analyzed through flow field simulation, and the main factors influencing erosion damage to the valve core were investigated. The results indicate that the side holes and flow channel structure of the valve core are the main causes of erosion. Based on this, two optimization schemes are proposed, namely, reducing the number of bypass side holes to 4 and optimizing the flow channel cone angle to 45°. The simulation results show that the erosion rate of the optimized valve core is significantly reduced, and the service life is effectively improved. Finally, a valve core life prediction model is established using a back propagation (BP) neural network to evaluate the optimization effect. The results show that the applicable flow range and maximum service life of the optimized valve core are increased by approximately 60% and 75.4%, respectively, validating the effectiveness of the optimization scheme.
Improved Sugar Recovery from Mandarin Peel under Optimal Enzymatic Hydrolysis Conditions and Application to Bioethanol Production
Authors: Son Hyerim , Lee Jeongho , Yoo Hah Young
Published: September 2024

Mandarin peel (MP) has gained attention as a feedstock for flavonoid recovery via the extraction process based on the biorefinery concept, but residues remain after the extraction. Toward an integrated biorefinery concept, this study aimed to valorize extracted MP (eMP) by using it in bioethanol production. For efficient fermentable sugar production, the effect of enzymatic hydrolysis conditions on sugar conversion from eMP was investigated, and the results showed that combining cellulase and cellobiase resulted in a higher enzymatic glucose conversion (78.2%) than the use of the individual enzymes (37.5% and 45.6%). Pectinase played an essential role in enhancing enzymatic arabinose conversion, and the optimal conditions were determined to be pH 4 and 90 units of the three enzymes. Under optimal conditions, the sugar yield was 199 g glucose and 47 g arabinose/kg eMP, and the hydrolysate was used in bioethanol fermentation. The results showed that the bioethanol production was 3.78 g/L (73.9% yield), similar to the control medium (3.79 g/L; 74.2% yield), although the cell growth of the yeast was slightly delayed in the eMP hydrolysate medium. This study highlights the potential of eMP as a low-cost feedstock for sugar and bioethanol production.
Use of Triboelectric Nanogenerators in Advanced Hybrid Renewable Energy Systems for High Efficiency in Sustainable Energy Production: A Review
Authors: Trinh Van-Long , Chung Chen-Kuei
Published: September 2024

Renewable energy is the best choice for clean and sustainable energy development. A single renewable energy system reveals an intermittent disadvantage during the energy production process due to the effects of weather, season, day/night, and working environment. A generally hybrid renewable energy system (HRES) is an energy production scheme that is built based on a combination of two or more single renewable energy sources (such as solar energy, wind power, hydropower, thermal energy, and ocean energy) to produce electrical energy for energy consumption, energy storage, or a power transmission line. HRESs feature the outstanding characteristics of enhancing energy conversion efficiency and reducing fluctuations during the energy production process. Triboelectric nanogenerator (TENG) technology transduces wasted mechanical energies into electrical energy. The TENG can harvest renewable energy sources (such as wind, water flow, and ocean energy) into electricity with a sustainable working ability that can be integrated into an HRES for high power efficiency in sustainable renewable energy production. This article reviews the recent techniques and methods using HRESs and triboelectric nanogenerators (TENGs) in advanced hybrid renewable energy systems for improvements in the efficiency of harvesting energy, sustainable energy production, and practical applications. The paper mentions the benefits, challenges, and specific solutions related to the development and utilization of HRESs. The results show that the TENG is a highly potential power source for harvesting energy, renewable energy integration, application, and sustainable energy development. The results are a useful reference source for developing HRES models for practical applications and robust development in the near future.
Thermodynamic Feasibility of Chemical Looping CO Production from Blast Furnace Gas Based on Fe-Ca-Based Carriers
Authors: Gao Yang , Xie Huaqing , Sun Chao , Qin Mengxin , Wang Kun , Shao Zhengri
Published: September 2024

In this paper, a novel process for synergistic carbon in situ capture and the utilization of blast furnace gas is proposed to produce CO via chemical looping. Through thermodynamic analysis, this process was studied in terms of the carbon fixation rate, CO yield, in situ CO2 utilization rate, CH4 conversion rate and energy consumption. It provides valuable insights for achieving efficient CO2 capture and in situ conversion. FeO and CaO are used as the oxygen carrier and the carbon carrier, respectively. Under the conditions of reaction temperature of 400 °C, pressure of 1 bar and FeO/CO ratio of 1, the carbon capture rate of blast furnace gas can reach more than 99%. In the carbon release reactor, the CO yield is lower than that in the original blast furnace gas (BFG) if no reduction gas is involved. Therefore, methane is introduced as a reducing gas to increase CO yield. When the reaction temperature is increased to 1000 °C, the pressure level is reduced to 0.01 bar and the CH4/C ratio is 1:1 (methane to carbon), the CO yield is four times that of the initial blast furnace gas. Under the optimal conditions, the energy consumption of the system is 0.2 MJ/kg, which is much lower than that of the traditional process. This paper verifies the feasibility of the new process from the perspective of thermodynamics.
Control Study on Surrounding Rock of Gob-Side Entry Retaining below near Distance Goaf
Authors: Xie Shengrong , Jiang Zaisheng , Chen Dongdong , Zhai Liwei , Yan Zhiqiang
Published: September 2024

To explore the control technology on surrounding rock of gob-side entry retaining (GSER) below a goaf in a near distance coal seam (NDCS), research was conducted on the floor ruin range, the floor stress distribution features, the layout of the GSER below near distance goaf, the width of the roadside filling wall (RFW), and the control technology of the GSER surrounding rock below the near distance goaf after upper coal seam (UCS) mining. The results show that (1) the stress of the goaf floor has obvious regional features, being divided into stress high value zone (Zone A), stress extremely low zone (Zone B), stress rebound zone (Zone C), stress transition zone (Zone D), and stress recovery zone (Zone E) according to different stress states. The stress distribution features at different depths below the goaf floor in each zone also have differences. (2) Arranging the roadway in Zone A below a coal pillar, the roadway is at high stress levels, which is not conducive to the stability of the surrounding rock. Arranging the roadway in Zone B below the goaf floor, the bearing capacity of the surrounding rock itself is weak, making it difficult to control the surrounding rock. Arranging the roadway in Zone C, the mechanical properties of the surrounding rock are good, and the difficulty of controlling the surrounding rock is relatively low. Arranging the roadway in Zone D and Zone E, there is a relatively small degree of stress concentration in the roadway rib. (3) When the RFW width is 0.5–1.5 m, stress concentration is more pronounced on the solid coal rib, and the overlying rock pressure is mainly borne by the solid coal rib, with less stress on the RFW. When the RFW width is 2~3 m, the stress on the RFW is enhanced, and the bearing capacity is significantly increased compared to RFW of 0.5–1.5 m width. The RFW contributes to supporting the overlying rock layers. (4) A comprehensive control technology for GSER surrounding rock in lower coal seam (LCS) has been proposed, which includes the grouting modification of coal and rock mass on the GSER roof, establishing a composite anchoring structure formed by utilizing bolts (cables); the strong support roof and control floor by one beam + three columns, reinforcing the RFW utilizing tie rods pre-tightening; and the hydraulic prop protection RFW and bolts (cables) protection roof at roadside. This technology has been successfully applied in field practice.
Assistive Control through a Hapto-Visual Digital Twin for a Master Device Used for Didactic Telesurgery
Authors: Pacheco Quiñones Daniel , Maffiodo Daniela , Laribi Med Amine
Published: September 2024

This article explores the integration of a hapto-visual digital twin on a master device used for bilateral teleoperation. The device, known as a quasi-spherical parallel manipulator, is currently employed for the remote center of motion control in teleoperated mini-invasive surgery. After providing detailed insights into the device’s kinematics, including its geometric configuration, Jacobian, and reachable workspace, the paper illustrates the overall control system, encompassing both hardware and software components. The article describes how a digital twin, which implements a haptic assistive control and a visually enhanced representation of the device, was integrated into the system. The digital twin was then tested with the device: in the experiments, one “student” end-user must follow a predefined “teacher” trajectory. Preliminary results demonstrate how the overall system can pose a good starting point for didactic telesurgery operation. The control action, yet to be optimized and tested on different subjects, indeed seems to grant satisfying performance and accuracy.