bluuebunny/crossref_metadata_2025 huggingface dataset:
العلاقة بين عدم موضوعية النظام الإشرافي وبعض الظواهر السلبية في التنظيم: دراسة ارتباطية مطبقة على المنظمات الكويتية
Authors: الدعيج حمد صالح , حموده عبدالناصر محمد
Published: December 2024

تستهدف الدراسة قياس مدى انتشار أبعاد عدم موضوعية النظام الإشرافي في المنظمة الكويتية وعلاقات الارتباط القائمة بين إدراكات الأفراد لهذه الأبعاد ومجموعة من المتغيرات الفردية والتنظيمية، علاوة على طبيعة العلاقات الارتباطية بين هذه الأبعاد وبعض الظواهر التنظيمية السلبية. أجريت التحليلات على بيانات مستقصاة من عينة مجموعات حجمها 606 مفردة، اختيرت عشوائيا من عاملين بمنظمات كويتية. أسفرت التحليلات عن بناء 17 نموذجا إحصائيا لتفسير أبعاد عدم الموضوعية والظواهر السلبية والتنبؤ بها. تشير الدراسة بصفة أساسية إلى أن التكلفة المترتبة على عدم موضوعية النظام الإشرافي تفوق
بكثير أي نتيجة إيجابية تتوقعها الإدارة منها.
تحليل وقت التأخير الإجمالي في عملية اتخاذ قرارات شراء السلع الاستهلاكية مرتفعة الثمن: دراسة تطبيقية
Authors: إدريس ثابت عبدالرحمن
Published: December 2024

يهتم هذا البحث بتحليل ظاهرة التأخير الإجمالي لفترة زمنية طويلة في عملية اتخاذ قرارات الشراء الخاصة بالسلع الاستهلاكية مرتفعة الثمن، والأسباب التي تؤدي إلى إنهاء هذا التأخير، والعلاقة بينهما. كما يهتم البحث بمعرفة ما إذا كان وقت التأخير يتفاوت بتفاوت المراحل المختلفة لعملية اتخاذ قرار الشراء الخاص بهذا النوع من السلع. وقد أظهرت النتائج أن عملية اتخاذ قرارات شراء هذا النوع من السلع يتعرض للتأخير لفترة زمنية طويلة من جانب نسبة كبيرة من المستهلكين، وخاصة في بعض مراحل هذه العملية، وذلك لأسباب متنوعة في مقدمتها ضغوط الوقت والقدرة الشرائية المتاحة والمخاطر المالية والنفسية المدركة لقرار الشراء وعدم توافر الخبرة في الشراء. كما أن هذه الظاهرة تتأثر بالخصائص الديموغرافية للمستهلك وخاصة دورة حياة الأسرة ومستوى الدخل والعمر.
تصميم نموذج كمي لقياس وطأة الخسارة لحوادث السيارات بدولة الكويت
Authors: حمدي حسني إبراهيم , المحميد محمد عبدالهادي , الحبشي معوض حسن
Published: December 2024

يهدف هذا البحث إلى دراسة العلاقة بين الصفات الديموغرافية للسائق ووطأة الخسارة (حجم الخسارة) في حالة وقوع حادث سيارة بدولة الكويت. وبالتحديد، فإن الدراسة تبحث في وجود علاقة بين وطأة الخسارة وبعض المتغيرات الديموغرافية للسائق مثل السن والجنس والجنسية ومكان وقوع الحادث. وقد اهتم البحث بدراسة هذه العلاقة من خلال تجميع بيانات خاصة بعدد من حوادث السيارات (345) خلال الفترة من 1994-1995 من واقع محاضر التحقيق الخاصة بهذه الحوادث في مخافر الشرطة بدولة الكويت. وفي هذا البحث تم استخدام التحليل اللوجستي والنماذج الخطية لبناء نموذج كمي لتقدير احتمال وقوع حادث ذي وطأة عالية (خسارة كبيرة) أو حادث ذي وطأة منخفضة (خسارة منخفضة). ويعرض البحث النتائج الخاصة بدرجة العلاقة بين المتغيرات الديموغرافية للسائق وحجم الخسارة.
محددات أداء شركات التأمين الكويتية: دراسة تحليلية
Authors: عبدالحميد عادل منير
Published: December 2024

تهدف هذه الدراسة إلى تحديد العوامل المؤثرة على مستوى أداء شركات التأمين ومدى أهميتها. وتنقسم تلك العوامل إلى مجموعات. المجموعة الأولى تتصل بطبيعة العمليات المقبولة من حيث طبيعة الأخطار المغطاة تأمينيا ودرجة خطورتها. المجموعة الثانية ترتبط بكفاءة أداء الوظائف الفنية والإدارية لشركات التأمين. والمجموعة الثالثة تتصل بخصائص سوق التأمين المحلية. وتنبع أهمية هذا البحث من توفير نتائج الدراسة كمؤشرات وأدوات مساعدة لشركات التأمين وهيئات الإشراف والرقابة تستخدم عند تخطيط السياسات التأمينية.
High-Intensity Laser Therapy – An Option for Managing the Pain in Anal Fissures
Authors: Cordeiro Time Sônia Cristina , Buffara Blitzkow Ana Carolina , Paz de Oliveira Fabrício Doin , Perondi Luana , Marques Elisa Treptow , Quaresma Abel Botelho , Marciano Marcelo , Sampietro Rodnei Bertazzo
Published: December 2024

Introduction: Anal fissures (AFs) are a prevalent pathology. Although internal lateral sphincterotomy is still the gold-standard surgery for treating chronic AFs, this procedure is associated with a considerable risk of anal incontinence. This study describes an alternative and minimally invasive technique for treating AFs using photobiomodulation and a high-power diode laser-fissure treatment (LFT) and highlights initial results pertaining to pain. Methods: This retrospective study focused on 38 patients treated with LFT on an outpatient basis at three different hospitals in different states of Brazil (Santa Catarina, Paraná, and São Paulo). The objective was to evaluate the effects of LFT treatment on AF patient pain following the procedure. The Friedman test was used to identify the effects of LFT treatment over time (D0, D7, D15, D30, and D60) on postoperative pain intensity using the visual analogue scale (VAS). Complications and incontinence rates were also analyzed. Results: Roughly two-thirds of the patients (66%; n=25) were male. The median age of the cohort was 49. Constipation was described by 32% of the patients, 13% were smokers, and 21% had recently used opioids. In 92% of the cases, the AF was localized posteriorly. Skin tags were present in 27% of the cases, and 26% had recently undergone a previous orificial surgery. A significant reduction in pain was observed over time in the intensity of postoperative pain measured by the VAS. Prior to surgery (D0), the patients’ mean VAS score was 4.1; it progressively decreased to 0.1 on the 60th postoperative day (P<0.05). There was no significant change in fecal continence at the end of the 60-day follow-up period. Minor complications occurred in 7.9% of the patients (2.6% hemorrhoidal thrombosis, 2.6% skin tag, and 2.6% "failure"). Conclusion: Our results suggest that treating AFs with laser therapy results in a significant reduction in pain intensity over time without interfering with anal continence.
Investigating the Effect of Photobiomodulation Therapy With Different Wavelengths of Diode Lasers on the Proliferation and Adhesion of Human Gingival Fibroblast Cells to a Collagen Membrane: An In Vitro Study
Authors: Karimi Mohammad Reza , Abdollahi Shahrzad , Etemadi Ardavan , Hakimiha Neda
Published: December 2024

Introduction: Photobiomodulation (PBM) is considered a promising adjunctive approach in regenerative medicine. This study aimed to investigate the proliferation and adhesion of human gingival fibroblast (HGF) cells to a collagen membrane following PBM. Methods: Cultured HGF cells on a collagen membrane received PBM at wavelengths of 808 nm, 915 nm (2 and 4 J/cm2 ), and 660 nm (2.1 and 4.2 J/cm2 ) in interventional groups, while non-irradiated cells served as the control. On days 1 and 3 post-irradiation, cell proliferation was measured by MTT assay, and adhesion to the membrane was assessed under the scanning electron microscope (SEM). Results: Cell proliferation significantly increased in interventional groups compared to the control, with the most significant increase at 915 nm (4 J/cm2 ) in both time points. On the first day, the 808 nm and 660 nm lasers demonstrated similar results, significantly lower than the 915 nm laser (2 J/cm2). On day 3, the 660 nm, 808 nm, and 915 nm (2 J/cm2) groups showed comparable results. Qualitative analysis by the SEM identified spindle-shaped cells with multiple extended projections in 915 nm groups, especially at an energy density of 4 J/cm2 . Groups of 660 nm and 808 nm (4 J/cm2 ) showed spindle-shaped cell morphology. No distinct cellular morphology indicative of enhanced adhesion was observed at 808 nm (2 J/cm2). Conclusion: The most effective PBM setup for promoting HGF proliferation and adhesion to a collagen membrane was identified at 915 nm (4 J/cm2 ).
Efficacy of the Orifice-Level Passive Ultrasonic Activation Technique in Removing Debris from Mandibular Molars: An Ex Vivo Study
Authors: Bolourchi Iman , Zargar Nazanin , Khosravi Kamyar , Mashhadiabbas Fatemeh , Akbarzadeh Baghban Alireza , Pourmousavi Leila
Published: December 2024

Introduction: This study aimed to evaluate the efficacy of the orifice-level passive ultrasonic activation (OL-PUA) technique in removing debris from the mesial root canals of mandibular molars, besides comparing it with other approaches, including manual dynamic agitation (MDA), EndoActivator, and laser-activated irrigation (LAI). Methods: Ninety mesial roots of mandibular molars were prepared up to 25.06 using the Race rotary system, filled with 3% sodium hypochlorite (NaOCl), and then they were randomly assigned to 5 groups (n=15) based on the activation protocol: MDA, EndoActivator, OL-PUA, LAI (using a diode laser), and needle irrigation (no activation). Moreover, one group served as the negative control using normal saline as the final irrigant. The roots were decalcified and sectioned into coronal, middle, and apical cross-sections. After histological staining, the remaining debris was assessed with an optical microscope and measured in the canals and isthmuses using histomorphometric analysis. Statistical analyses were performed by using one-way ANOVA and Tukey’s HSD post hoc test (P=0.05). Results: Although less residual debris was observed after OL-PUA/LAI than using the EndoActivator/MDA methods, no significant difference was found between the four activation techniques at any root third (P>0.05). The OL-PUA/LAI group harbored significantly less remaining debris than the needle-irrigated samples at all root thirds (P<0.05). Debris accumulation increased from the coronal to the apical root thirds. Conclusion: No statistical difference was detected between the four activation techniques in terms of debris-removal performance, and none of them resulted in completely debris-free canals. Orifice-level PUA proved to be a promising approach with significant efficacy in removing debris compared to control groups.
Differential Sandwich Theorems for Mittag-Leffler Function Associated with Fractional Integral Defined by Convolution Structure
Authors: Jabir Noor Yasser , Wanas Abbas Kareem
Published: December 2024

In this work, we use fractional integral and Mittag-Leffler function to obtain some results related to differential subordination and superordination defined by Hadamard product for univalent analytic functions defined in the open unit disk. These results are applied to obtain differential sandwich results. Our results extend corresponding previously known results.
ТОПИОНИЦЕ – ЈЕЗГРА НОВИХ НАСЕЉА У РУДАРСКИМ ОБЛАСТИМА ВУЧИТРНСКОГ САНЏАКА (15–16. ВЕК)
Authors: Katić Tatjana
Published: December 2024

The paper focuses on smelteries as a factor influencing settlement in a region of the medieval mine of Novo Brdo in the sancak of Vučitrn (Vılçitrn). It aims to determine the number of smelters’ villages and to analyse their dynamics, especially in the context of the rise and fall of mining production. Based on an analysis of the 15th and 16th-century tapu tahrir defters of the abovementioned area, it will be shown that the number of smelters’ villages was much larger than would appear from an examination of previous studies. They were assembled in very small nahiyes created in accordance with the metallurgical production, not the geographical features of the territory concerned, as was usual. Their inhabitants were more often than not of diverse ethnic origins and religious affiliations.
ГЕОГРАФСКИ ПОЈАМ СТАРИ ВЛАХ – ОД НАСТАНКА ДО НЕСТАНКА
Authors: Ilić Žarko
Published: December 2024

In this paper an analysis is provided of how the geographical term Stari Vlah came into being and how it was understood by people until it fell into disuse. The first half of this paper is dedicated to the origins of the term Stari Vlah/Stari Vlasi, with an analysis of how this term was used in the available sources, beginning from the second half of the 16th century. Also provided is insight into those elements which had the most influence in defining the borders of Stari Vlah and how it was perceived as a geographical entity, with special attention given to the borders of Ottoman legal-administrative divisions, i.e. the existence of the Stari Vlah kadiluk. The second half of this paper provides a detailed definition and reconstruction of the borders of Stari Vlah and the fate of this term after the region was divided between the Principality of Serbia and the Ottoman Empire in the early 1830s. This paper incorporates material from both published and unpublished sources, as well as literature.
К 90-ЛЕТИЮ БЮЛЛЕТЕНЯ КОМИССИИ ПО ИЗУЧЕНИЮ ЧЕТВЕРТИЧНОГО ПЕРИОДА
Authors: Второв И.П.
Published: December 2024

Группа истории геологии, Геологический институт РАН, Москва, vipginras.ru Бюллетень Комиссии по изучению четвертичного периода был впервые напечатан в 1929 году Комиссией по изучению четвертичного периода, созданной в 1927 году при АН СССР. Организатором и первым редактором Бюллетеня был академик Франц Юльевич Левинсон-Лессинг (18611939). В разделе История науки будут публиковаться материалы по учёным и организациям, внёсшим существенный вклад в изучение четвертичного периода и работу Комиссии.

In 1929, the first Bulletin of the Commission for Study of the Quaternary (BCSQ) was published by the Commission for the Study of the Quaternary, established in 1927 under the USSR Academy of Sciences. The organizer and the first editor of the Bulletin was academician F.Yu. Levinson-Lessing. New History of Science section include papers about scientists who have made significant contributions to the work of the Commission and the study of the Quaternary period.
Строение, морфогенез и кинематика гравитационного позднечетвертичного покрова юго-западной части Северного Прикаспия
Authors: Лаврушин Ю.А. , Антипов М.П. , Кураленко Н.П. , Спиридонова Е.А. , Тудрин А.
Published: December 2024

В пределах пологого рельефа Северного Прикаспия установлено наличие маломощного позднечетвертичного гравитационного покрова. Разработаны индикаторы проявления гравитационных кинемато-динамических процессов. Важнейшим результатом исследований явился вывод об их постседиментационном происхождении в парагенезе с высокоскоростными регрессивными событиями Каспия. Созданы модели формирования изученных типов бэровских бугров, важнейшими среди которых явились: будинированные, протрузионные, бугры зон сжатия, а также очагово-сейсмический тип. Предложенная в настоящей статье концепция о строении, морфогенезе и кинематике молодого позднечетвертичного гравитационного покрова может представить интерес для исследователей, изучающих древние аналогичного типа структуры.

The presence of a thin Late Quaternary gravitational cover defined within the shallow relief of the Northern Caspian region. Indicators of gravitational kinematic-dynamic processes are developed. The most important result of the research was the conclusion about their post-sedimentary origin in paragenesis with high-speed regressive events of the Caspian Sea. The studied Baer knolls formation models were developed, the most important: boudinaged, protrusive, knolls of compression zones, as well as focal seismic type. The proposed concept of the structure, morphogenesis, and kinematics of a young Late Quaternary gravitational cover may be useful and interesting for researchers studying similar type ancient geological structures. Keywords: Structure, morphogenesis and kinematics of Late Quaternary gravitational cover of the southwestern part of the Northern Caspian region.
Базальтовые силлы в плейстоценовых осадках калифорнийского залива (проБлема вторичной калиевой минерализации)
Authors: Гептнер А.Р. , Горькова Н.В. , Коновалов Ю.И. , Курносов В.Б. , Михеев В.В.
Published: December 2024

Исследование состава тонкодисперсного материала в базальтах в плейстоценовых осадках впадины Гуаймас Калифорнийского залива выявило на некоторых горизонтах плейстоценового разреза в составе силлов помимо ранее известных смектитов ещё и биотита. Изучение петрографических и полированных шлифов в оптическом и в сканирующем электронном микроскопах установило терригенный генезис биотита, захваченного из вмещающих осадков внедряющимся расплавом, из осадочной части разреза. Крупные обломки биотита хорошей сохранности встречены в трещинах корки закала, мелкие фрагменты неравномерно распределены в зоне закала. Крупные фрагменты биотита имеют следы растворения и частичного замещения зелёным глинистым веществом (смектитом). Предполагается, что в основной части силлов захваченные биотиты были разрушены полностью. Источником оксида калия (0.607.00) в составе новообразованных смектитов, сформировавшихся в интерстициях базальта, был биотит, разрушенный внедряющимся расплавом и перемещённый в силле термальным раствором. Выделение слоистых силикатов в жилках, рассекающих основную массу базальтов и крупные кристаллы плагиоклазов определённо указывает на их формирование из растворов. Наличие оксидов калия в составе вторичных глинистых образований базальтов подтверждает миграцию термальных растворов в горизонтах силлов.

Basalt sills intruded in unconsolidated Pleistocene hemi pelagic sediments in the Guaymas Basin of the Baja California Peninsula have been studied in thin sections by optical and by scanning electron microscope. Several hydrothermal minerals have been established but biotite for the first time in basalt sills. It is terrigenous mineral captured during basalt magma intrusion into sediments having biotite fragments. The large fragments of biotite have been found out in opening mode cracks of the basalt zone chilling. The small fragments of biotite are numerous in this zone. Some of the large biotite fragments have been partially replaced by smectites. In the middle part of sills all biotite fragments have been completely destroyed. In basalts some of the clay minerals (smectites) contain up to 0.67.0 of K2O. The source of this component was terrigenous fragments of biotite captured from sedimentary deposits. Precipitation of K2O with clay minerals in basalts allows suggests migration of thermal solutions through sills horizons.
ГЛЯЦИОГЕОМОРФОЛОГИЧЕСКИЕ РЕКОНСТРУКЦИИ ИНФРАСТРУКТУРЫ КРАЕВЫХ ЗОН РАЗНОВОЗРАСТНЫХ ОЛЕДЕНЕНИЙ В БАССЕЙНЕ ВЕРХНЕЙ ВОЛГИ И ОКИ
Authors: Судакова Н.Г. , Антонов С.И.
Published: December 2024

На основе комплексного палеогеографического анализа проведена реконструкция радиально-маргинальной структуры московского и калининского ледниковых покровов с использованием надежной стратиграфической основы и детальных геоморфологических построений. На составленной геоморфологической карте отражена инфраструктура краевых ледниковых образований разновозрастных зон. Подтверждается радиальная потоковая структура ледниковых покровов. Обоснована маргинальная структура и динамика стадиальных зон московского и калининского оледенений. Уточнены границы их максимального распространения в регионе. Установленные пространственные и временные закономерности развития ледниковой ритмики в центральном регионе Русской равнины имеют важное палеогеографическое значение.

Based on a comprehensive paleogeographic analysis, the radial-marginal structure of the Moscow and Kalinin ice sheets was reconstructed using a reliable stratigraphic base and detailed geomorphological structures. The geomorphological map shows the infrastructure of the regional glacial formations of uneven age zones. Confirms the radial flow structure of the ice caps. The marginal structure and dynamics of the stadial zones of the Moscow and Kalinin glaciations are substantiated. The boundaries of their maximum distribution in the region are specified. The established spatial and temporal patterns of the development of glacial rhythms in the central region of the Russian Plain have an important paleogeographic significance.
ГЕОЛОГИЧЕСКОЕ РАЗВИТИЕ РИФТОВЫХ И ШОВНЫХ МОРФОСТРУКТУР СЕВЕРО-ВОСТОКА РОССИИ В КВАРТЕРЕ
Authors: Друщиц В.А.
Published: December 2024

Рассмотрено геологическое развитие в квартере сквозных морфоструктурных ансамблей, пересекающих Северо-Восток России в субмеридиональном и субширотном направлениях. Рифтовый бассейн моря Лаптевых прослеживается от хребта Гаккеля до верховьев р. Индигирки. Колючинско-Мечигменский рифт протягивается от Берингова моря через Чукотский полуостров до котловины Подводников. Южно-Анюйский коллизионный шов распространяется от Берингова моря практически через весь Северо-Восток России до моря Лаптевых. В квартере для этих морфоструктур характерно проявление вертикальных и горизонтальных движений, сейсмичности, вулканизма, разгрузки термальных вод. Новейшие движения влияют на положение границы между сушей и морем, между реликтовыми гляциальными и перигляциальными зонами. Локальные неотектонические блоковые структуры консервируют реликтовые осадочные образования ледовый комплекс (едома). Ключевые слова: рифтовая система моря Лаптевых, Колючинско-Мечигменская рифтовая система, Южно-Анюйская сутура, новейшая тектоника, квартер.

The article deals with the Quaternary geological evolution of cross cutting morphostructures of the Russian Northeast. They have submeridional and sublatitudinal directions. The Laptev Sea rift morphostructure begins from the Gakkel Ridge and closes in the Indigirka River upper course. Koluchinsko-Mechigmensk morphostructure is between the Bering Sea, through Chukotka peninsula to Podvodnikov basin. South Anyui suture reaches from the Bering Sea through Russian Northeast up to Laptev Sea. There are phenomenon of vertical and horizontal movements, seismicity, volcanism and hydrothermal springs in the Quaternary for all of them. Neotectonic activity has influenced on position of boundary between sea and land between relict glacial and periglacial zones. Local neotectonic block structures preserve relict endemic sedimentary ice complex (edoma).
PREDICTION OF POLYMER COMPATIBILITY FOR POLYMER ELECTROLYTES USING SEMI-EMPIRICAL QUANTUM CHEMICAL METHOD
Authors:   Volgograd State Technical University, EZHOV D. V. , GAYDADIN A. N. ,   Volgograd State Technical University, KLIMOV V. V. ,   Volgograd State Technical University
Published: December 2024

The article proposes a method for predicting the compatibility of polymers for polymer electrolytes using the semi-empirical PM3 method, as well as the PM3 method using boundary conditions called a periodic box. Using the proposed method, a compatibility prediction was made for polymer pairs: ethylene-propylene rubber and polyethylene, polyvinylidene fluoride and hydrogenated nitrile butadiene rubber.
INVESTIGATION OF THE EFFECT OF TREATMENT MODES OF ALUMINOSILICATE MICROSPHERES WITH LOW-TEMPERATURE PLASMA ON THE PROPERTIES OF ELASTOMERIC FIRE- AND HEAT-PROTECTIVE MATERIALS
Authors:   Volgograd State Technical University, KABLOV V. F. , KOCHETKOV V. G. ,   Volgograd State Technical University, KEIBAL N. A. ,   Volgograd State Technical University, NOVOPOLTSEVA O. M. ,   Volgograd State Technical University, KRYUKOVA D. A. ,   Volgograd State Technical University, URZHUMOV D. A. ,   Volgograd State Technical University, SHESTERNIN M. I. ,   Volgograd State Technical University, MYASNIKOV I. M. ,   Volgograd State Technical University, DROZDEV V. A. ,   Volgograd State Technical University
Published: December 2024

An urgent task of our time is to expand the temperature limit of the operating modes of elastomeric materials. One of the promising directions for solving this problem is the use of bulging and hollow fillers, including aluminosilicate microspheres, in elastomeric compositions. The influence of modification modes (discharge power and duration of exposure) of the surface of aluminosilicate microspheres by low-temperature plasma on the properties of flame-retardant elastomeric materials based on ethylene propylene diene rubber has been studied. It is shown that the treatment carried out makes it possible to increase the polymer-filler interaction, the conditional strength of the material, and the coke residue.
Hydrocortisone and vitamin B12 protect SHSY-5Y cells against glutamate excitotoxicity by altering VIP and GAL levels
Authors: Genç Sıdıka , Karabulut Kübra , Niğde Esmanur , Taghizadehghalehjoughi Ali
Published: December 2024

Background: Prolonged elevation of extracellular glutamate levels triggers intracellular events, increases glutamate excitotoxicity, and activates apoptotic pathways, causing Alzheimer's disease (AD). The literature has reported that vitamin B12 exhibits anti-inflammatory and anti-apoptotic activities in various diseases. Hydrocortisone (HC) therapy also substantially inhibits microglia and astrocyte hyperactivation, minimizing pro-inflammatory cytokines and reducing neuroinflammation. That is why our study aimed to evaluate the therapeutic effects of HC and B12 combination on oxidative stress and VIP and GAL levels in an in vitro Alzheimer's model.
Method: To create the Alzheimer's model, the neuroblastoma cell line (SH-SY5Y) was cultured. Then, all cells except the control group were treated with different doses of HC and B12 combination for 24 hours by applying Glutamate (10-5 mM) to create excitotoxicity. The results were evaluated using MTT and ELISA tests.
Results: When the results were examined, it was determined that exceptionally high-dose combination groups showed protective activity against glutamate excitotoxicity. HC+B12 25 µg/ml groups observed the most statistically significant results. According to our results, oxidative stress decreased in the HC+B12 25 µg/ml group, and cell viability increased. Significant changes were also observed in Vasoactive Peptide (VIP) and Galanin (GAL) levels in correlation with other analyses obtained.
Conclusion: This study is the first to report the potential of vitamin B12 combined with hydrocortisone to prevent oxidative stress and glutamate excitotoxicity in primary neurons. It provides a basis for further investigating its clinical application in neurodegenerative diseases.
Artvin Maden Köyü’nün Doğal - Kültürel Mirasının Korunması, Tanıtılması ve Ekolojik Turizme Kazandırılması
Authors: Akat Reyhan , Çakıroğlu Birgül
Published: December 2024

Artvin ilinin Şavşat ilçesinde yaklaşık 1900 m. yüksek rakımlı dağlık alandaki Bazgiret Köyü doğal güzelliği, geleneksel sosyo-kültürel yaşam tarzı, yerel konut mimarisi ve özellikle de ahşap işçiliğiyle kırsal ekolojik turizm açısından önemli bir potansiyele sahiptir. Çalışmanın amacı, coğrafi konum olarak ulaşılması zor zirveye yakın bu köyün özgün doğal, ekolojik ve kültürel değerlerinin belirlenip tanıtımının yapılması, mevcut sorunlarla birlikte doğal mirasın acilen korunması ve sürdürülebilirliğin gerekliliğini ortaya koymaktır. Bu kapsamda, verilerin tespit edilmesi için yerinde yapılan gözlem, inceleme ve fotoğraflama yöntemlerinden yararlanılmıştır. Yapılan araştırmada; doğa yürüyüşü yapabilme, tarihi ve kültürel eserleri görebilme, yaban hayatı gözleme ve doğal güzellikleri seyredebilme, fotoğraflama amacıyla doğal ve kültürel etkinliklerin günübirlik, hafta sonu ya da daha uzun süreli gerçekleştirilebileceği alanlar tespit edilmiştir. Ayrıca, bu alana gelen ziyaretçilerin katı atıklarıyla çevreye verdikleri çeşitli kirlilikler belirlenmiştir. Ahşap malzemenin çevresel etkiler ile bozulmalara uğradığı gözlemlenmiştir. Ahşap yapıların korunarak restorasyonunun yapılması zorunludur. Ekolojik turizme kazandırılması amacıyla yöreye ait doğa ve yapı ilişkisindeki dengenin sağlanması amacıyla tasarım ve uygulama ölçütlerinin belirlenmesi, koruma amaçlı imar planlarının yapılması, yerel yönetim ve halk işbirliğiyle çalışılması gereklidir.
Rize İli Atık Su Arıtma Tesislerinde Mikroplastik Konsantrasyonlarının Belirlenmesi
Authors: Akdemir Tolga
Published: December 2024

Bu çalışma, Türkiye’nin en yağışlı ili olan Rize’deki kentsel atık su arıtma tesislerinde mikroplastik (MP) kirliliğini incelemek üzere gerçekleştirilmiştir. Çalışmada, yağışlı ve kurak dönemlerdeki mikroplastik miktarları, şekilleri (fiber, fragment, film, foam) ve polimer türleri (PET, PP, PE, PS, PVC) arasındaki dönemsel farklılıklar analiz edilmiştir. Sonuçlar, mikroplastik yoğunluğunun mevsimsel dalgalanmalar gösterdiğini, ancak istatistiksel olarak anlamlı bir fark bulunmadığını ortaya koymuştur. Çalışma boyunca en yaygın şekilsel tür fiber olarak tespit edilmiş, polimer türlerinde ise PET’in baskın olarak öne çıkmıştır. Özellikle tekstil ürünlerinden kaynaklanan liflerin mikroplastik kirliliğinde belirgin bir payı olduğu saptanmıştır. Film ve foam türlerinde mevsimsel farklılıklar gözlemlenmiş, bu durumun çevresel koşullara duyarlılık gösterebileceği vurgulanmıştır. MP kirliliğinin kaynaklarının anlaşılması ve etkili giderim teknolojilerinin geliştirilmesi için daha kapsamlı ve uzun vadeli araştırmalar önerilmektedir.
Concatenación de capitales culturales, ambientales, políticos y físicos en el desarrollo del turismo sostenible de la colina de San Sebastián, ciudad de Cochabamba
Authors: López Rosse Eduardo
Published: December 2024

La Coronilla representa un símbolo de la bravura y el heroísmo de la mujer boliviana al hacer frente a los españoles en 1812, por lo cual ésta es recordada cada 27 de mayo. Sin embargo, esta colina es también una isla de la biodiversidad a pesar de ser perturbada por construcciones físicas que han alterado el paisaje natural. Estas acciones la han convertido en un caso de éxito interesante donde se concatenan los capitales cultural, natural, físico y político, que pueden ser abordados por el desarrollo del turismo sostenible para mejorar el flujo turístico en el departamento, así como también crear nuevos circuitos turísticos y otros emprendimientos empresariales sociales con el manejo de productos forestales no maderables para sustentar la conservación de este sitio histórico y natural en medio de la ciudad de Cochabamba.
Conferencia Internacional Innova 2024
Authors: Chavez Georgina
Published: December 2024

Los días 11 y 12 de marzo de 2024 se llevó cabo en la sede paceña de la Universidad Católica Boliviana “San Pablo” la Conferencia Internacional Innova 2024, bajo el título “La investigación científica: una aproximación desde la gestión, su rol estratégico en el desarrollo y su contribución en el contexto de la crisis climática”. La conferencia tuvo por objetivos fundamentales, en primer lugar, analizar los retos y oportunidades para impulsar la ciencia, la investigación y la innovación en Bolivia, Paraguay y la región, con atención en gestión de la investigación y cambio climático, y en segundo lugar, promover el intercambio de experiencias, opiniones y perspectivas en cuanto a los temas de gestión de la investigación y cambio climático, con énfasis en Bolivia y Paraguay, en el entorno libre que proporciona la academia.
“Siempre he procurado que sepas donde estoy”: El Chaco en el género epistolar
Authors: Echazú Conitzer Alejandra
Published: December 2024

La joven poeta boliviana Yolanda Bedregal recibe cartas de sus amigos pintores, escritores, poetas desde la zona bélica del Chaco (1932-1935). Éstas reflejan la vida íntima y triste desde la guerra de estos muchachos que vieron truncada su vida de estudiantes y que tuvieron que aprender a matar a quienes no veían siquiera como enemigos. Estas misivas inéditas forman un pequeño archivo de uno mayor que sería imposible insertar en una revista.
Hilda Mundy, periodista de guerra
Authors: Ayllón Virginia
Published: December 2024

El texto es una aproximación al ejercicio del periodismo de guerra de la periodista y escritora orureña Laura Villanueva (1912-1982), más conocida como Hilda Mundy, en el objetivo de apreciar sus impresiones sobre la Guerra del Chaco (1932-1935), en los textos que escribió entre 1932 y 1936. Se ha utilizado un corpus constituido por el opúsculo Impresiones de la Guerra del Chaco, publicado póstumamente (1997), y tres columnas de periódicos orureños en las que escribió sobre la guerra. Los resultados indican que Mundy registró la guerra y su pensamiento sobre el conflicto bélico con el estilo irónico e iconoclasta que ha sido ya identificado por la crítica literaria. Pero en estos textos de la guerra incluye elementos afectivos que son novedosos en su escritura. Este análisis confirma que Mundy fue una escritora vanguardista que desarrolló en su escritura un proyecto ácrata, en referencia al tema de la guerra y a los otros asuntos centrales que captaron su atención (la ciudad, la mujer, la escritura).
Confesiones de un soldado en el Chaco: un análisis de las notas (críticas) de guerra del Tcnl. Carlos Soria Galvarro
Authors: Vera de Rada Ignacio Rodrigo
Published: December 2024

Este breve ensayo tiene un fin modesto: comentar, matizar y glosar las Notas de mi agenda: la Guerra del Chaco, del teniente coronel Carlos Soria Galvarro. Lo hago porque analizar la folletería y escribir sobre ella, como saben los especialistas en temas históricos e historiográficos, puede aportar algunos datos pequeños pero valiosos a la reconstrucción del relato de la historia, la cual es siempre plural, enmarañada y opaca. A lo largo de este ensayo, glosaré las notas críticas que considere más interesantes de Soria Galvarro, y no así las quejas o asertos que puedan resultar repetitivos o ya muy conocidos a través de otros autores post guerra del Chaco.
Memorias de guerra: Víctor Saravia y María Ledo
Authors: Ballesteros Saravia Franz
Published: December 2024

En el presente artículo se expone un testimonio de la Guerra del Chaco a partir de los recuerdos de mi madre, quien a su vez se basa en los relatos de su abuela. La memoria actúa como ondas de un eco que reverberan en la conciencia colectiva y que poco a poco, con el paso de los años (89 desde el cese de hostilidades), se diluyen. Cuando el recuerdo se diluye también se difumina nuestra memoria moral. Aunque no viví la guerra en carne propia, mi familia, al igual que muchas otras, fue condicionada, fracturada y destinada a sobrellevarla, permitiéndose decisiones que, en el contexto de su generación, definieron el devenir de Bolivia.
Students' perceptions of agenda 2030 and its impact on higher education
Authors: Carrillo-Beltrán Julio César Cuauhtémoc , Llanos-Ramírez María del Carmen , Ramírez-Jiménez Armando , Bogarin-Correa María Romelia
Published: December 2024

The article presents a study conducted with 155 students from the Academic Unit of Accounting and Administration (UACyA) of the Autonomous University of Nayarit, exploring students' perceptions of the 2030 Agenda for Sustainable Development. A descriptive quantitative approach was employed, using a survey administered to students from different semesters and analyzing the data through descriptive statistics. The research aims to determine the level of knowledge, attitudes, and expectations of students regarding the 2030 Agenda. While most students understand the importance of the 2030 Agenda and its impact on the future, there is a gap between their perception and the actual integration of the SDGs into their study plans. The lack of a consistent focus on the SDGs hinders students' preparedness to contribute practically to sustainable development. Greater integration of the SDGs into university research is required, promoting collaboration between the UACyA, governments, and international organizations to holistically address global challenges. To ensure that future generations are equipped to contribute to a sustainable future, the UACyA must adopt a proactive approach, including the SDGs in study plans, promoting research and experiential learning, and raising awareness about the 2030 Agenda. This study suggests the need to implement strategies that promote the understanding and application of the 2030 Agenda in higher education.
Lord's Paradox Illustrated in Three-Wave Longitudinal Analyses: Cross Lagged Panel Models Versus Linear Latent Growth Models
Authors: Lin Hua , Larzelere Robert
Published: December 2024

Lord’s (1967) paradox showed that two basic ways to analyze change longitudinally can produce contradictory results in 2-occasion nonrandomized studies. This study extends that paradox to difference-score and ANCOVA-type residualized change score analyses across three waves of data for four corrective actions thought to be effective: corrective disciplinary actions by parents (timeout and reasoning) and corrective actions by professionals (psychotherapy and hospitalization). All significant findings indicated that these corrective actions were harmful according to cross-lagged panel models but beneficial according to linear latent growth models. One type of analysis may not generalize to the other type of analysis. These results are consistent with recent recognition that ANCOVA-type analyses are biased by invariant between-person differences, but difference-score analyses can have their own biases. Recognition of these biases is needed to discriminate between stronger and weaker causal evidence in longitudinal analyses.
Edukasi Cyber untuk Peningkatan Literasi Digital: Menuju Desa Smart People
Authors: Fajri Fathorazi Nur , Moh. Dzikrillah  , Ahmad Khairi
Published: December 2024

Kegiatan Pengabdian kepada Masyarakat (PKM) di Desa Karanganyar bertujuan meningkatkan literasi digital masyarakat, khususnya dalam penggunaan media sosial yang bijak dan bertanggung jawab. Program ini penting karena tingginya penggunaan media sosial belum diimbangi pemahaman tentang keamanan, etika, dan dampak negatif seperti hoaks dan cyberbullying. Edukasi ini dirancang untuk mewujudkan Desa Karanganyar sebagai "Desa Smart People" yang adaptif terhadap perkembangan teknologi. Analisis situasi menunjukkan rendahnya literasi digital dan minimnya edukasi formal di desa tersebut. Untuk mengatasi tantangan ini, diterapkan metode berupa ceramah, diskusi interaktif, simulasi praktis, serta pendampingan pasca-program. Keberhasilan kegiatan ini didukung oleh partisipasi aktif pemerintah desa dan tokoh masyarakat. Hasil program menunjukkan peningkatan signifikan dalam pemahaman peserta terkait literasi digital, bahaya hoaks, dan pentingnya menjaga privasi. Perubahan perilaku masyarakat terlihat dalam sikap yang lebih selektif terhadap informasi yang disebarkan. Program ini juga mendorong pemanfaatan media sosial untuk promosi produk lokal dan pariwisata desa. Secara keseluruhan, program ini meletakkan dasar transformasi digital di Desa Karanganyar dan dapat direplikasi untuk membangun masyarakat yang cerdas teknologi di desa lain.
STRATEGI BADAN PENDAPATAN DAERAH KABUPATEN BUTON TENGAH DALAM UPAYA PENINGKATAN PENDAPATAN DAERAH
Authors: Samiun  , Muh. Amir  , Dwi Putranto Riau
Published: December 2024

This study aims to analyze the Regional Revenue Agency (BAPENDA) planning strategies of Buton Tengah Regency in increasing regional income. Using a qualitative approach, the study involved 20 respondents selected through a PSS (5:1) mechanism and 5 informants chosen purposively. Data collection was conducted through a series of in-depth interviews to evaluate organizational performance based on five key dimensions: productive efficiency, service standards, responsiveness, compliance level, and management transparency. Data analysis employed the interactive approach developed by Milles and Huberman. The findings indicate that the performance of BAPENDA Buton Tengah is rated as "satisfactory" when assessed across these five dimensions. To enhance regional revenue, BAPENDA implements tax planning strategies to maintain tax burdens at an optimal level, allowing companies or individuals to meet tax obligations while maximizing financial benefits or efficiency. Generally, the ideal tax planning percentage for Buton Tengah is measured by Tax Revenue Efficiency (a minimum of 20%-25% of total PAD) and a balanced Tax Ratio in the range of approximately 10%-15%, depending on the main economic sectors of Buton Tengah.
Transition between low- and high-noise modulation instability microcombs in a silicon nitride microresonator
Authors: Kogure Soma , Sugano Ryo , Fujii Shun , Tanabe Takasumi
Published: December 2024

We developed a systematic measurement method that simultaneously captures pump detuning, the optical spectrum, RF beat noise, and the linewidth of a microresonator frequency comb. This comprehensive measurement approach enables us to investigate and visualize the phase transition between two distinct states within the modulation instability (MI) comb: a low-noise state (MI comb phase 1) and a high-noise state (MI comb phase 2). While phase 2 is typically recognized as the MI comb, our findings suggest that phase 1 represents a transition from the Turing pattern to the MI comb, maintaining a low-noise profile despite exhibiting the spectral characteristics of an MI comb.
Development of a full field-of-view spectroscopic single-molecule fluorescence instrument with improved methods for calibration
Authors: Yi Deqi , Deng Shangyuan , Tan Chuang , Ma Jie
Published: December 2024

We have developed a high-throughput, full field-of-view (FOV) spectroscopic single-molecule fluorescence instrument, overcoming distortion issues with gratings and prisms. Our calibration techniques ensure spectral uniformity across the whole FOV, and our two-step Gaussian fit method enables better than 2 nm precision in spectral peak determination for accurate molecule identification, making it a valuable tool for multi-color single-molecule detection and analysis.
Enhancing Indonesian National Police Penal Mediation Through Conflict Mediator Certification for Bhabinkamtibmas
Authors: Muhammad Akbar Magistra Putra
Published: December 2024

This research seeks weaknesses in the internal police regulations concerning the duties of Bhayangkara Pembina Keamanan dan Ketertiban Masyarakat (Bhabinkamtibmas). There was a conflict in the duties of the Bhabinkamtibmas, which is tasked with maintaining the security of public safety (Harkamtibmas), but can also carry out criminal investigation duties, penal mediation. Penal mediation embodies the concept of restorative justice which has been implemented by the Indonesian National Police (INP) through the role of Bhabinkamtibmas. Doctrinal study is being used in this research, where it used documents found regarding the problem. The document analysis is conducted toward documents informing the implementation of conflict mediator certification for Bhabinkamtibmas in case of horizontal conflict resolution, such as related internal police regulations. From documents analyzed, it was found that there has been an absence of regulation in place for Bhabinkamtibmas regarding penal mediation mechanism. Apart from their main duty ensuring public safety, Bhabinkamtibmas is expected to support the INP in carrying out their functions, including criminal investigations to resolve cases outside court. Practically, there have been some problems with horizontal conflict management by Bhabinkamtibmas. Based on this, the author initiated to certify conflict mediators within the Bhabinkamtibmas to enhance the effectiveness of INP penal mediation.
Institutional and Social Pressure in Violating the Police Code of Ethics
Authors: Wirawan Hendra , Koesbardiati Toetik , Sutinah
Published: December 2024

Institutional and social pressures on police officers often lead to violations of the code of ethics. This study aims to determine how institutional and social pressures can encourage ethical violations committed by police officers. This research is a qualitative study based on in-depth interviews with seven informants to explore and precisely describe the social phenomena that occur. The theory of anomie and the new institutional theory serve as the analytical tools in this research to produce unique and comprehensive findings. The research findings affirm that there are two types of police in responding to institutional pressure: police who view institutional pressure as a whip to work harder, and police who feel pressured by that pressure. In addition to institutional pressure, police also face social pressure in the form of demands to meet public expectations, which include: (1) police as 'all- knowing gods'; (2) police as superheroes for the community; and (3) police acting as influencers. The disparity in access and resources among police officers in meeting institutional and societal expectations drives some members to experience ethical conflicts that result in violations of the code of ethics. In institutional theory, ethics should serve as a tool to regulate behavior. In reality, this is hindered by unequal access and resources for each member within an institution, in this case, police officers. As a result, police officers who do not have adequate access and resources are driven to commit ethical violations to respond to institutional and social pressures.
The first record of Helophorus minutus Fabricius, 1775 (Coleoptera: Helophoridae) for Portugal with some notes about H. calpensis Angus, 1988
Authors: Shatrovskiy A. G. , Angus R. B.
Published: December 2024

Helophorus minutus Fabricius, 1775 is reported for the first time from mainland Portugal. Data on the possible presence of the closely related species H. calpensis Angus, 1988 is presented. Maps of the collecting places of both species in Portugal and the general distribution of H. minutus are given. 59 figs., 17 refs.
Determination of the efficacy of the antiviral drug "NanoViroSan" in pigs
Authors: Selishcheva N. V. , Kolchyk O. V. , Buzun A. I. , Bogach M. V. , Bogach D. M. , Rudenko Ye. V. , Bugaychuk V. B.
Published: December 2024

Porcine reproductive and respiratory syndrome (PRRS) and porcine parvovirus infection are contagious diseases of pigs characterized by impaired reproductive function in sows, abortions, and the birth of mummified, dead, or weak piglets with high mortality. To date, vaccine prophylaxis has improved reproduction rates, but it does not solve the problem of eradicating the disease completely, and significant economic losses require systematic improvement of means of combating them. The development of new domestic low-toxic and highly active agents with a wide range of antiviral activity will significantly improve the epizootic situation with these viral diseases in the country. The aim of our work was to evaluate the effectiveness of the newly developed drug “NanoViroSan” in sows with reproductive disorders. The study was conducted in a stationary disadvantaged farm on sows with reproductive system damage caused by the association of PRRSV and PVS viruses, with the manifestation of underdeveloped offspring and respiratory disease in young animals. For the treatment of pigs, a drug with antiviral activity “NanoViroSan” was used, which contains Methisazone (inhibits mRNA synthesis in poxviruses) and Amixin (effective against influenza viruses, other acute respiratory viral infections, hepatitis A, B, C, and herpesviruses) with the addition of magnesium nanoxide with bactericidal action. 56 farrowing sows with reproductive disorders were treated with “NanoViroSan” at the rate of 1 cm3/10 kg, in the neck muscles for 3 consecutive days (I course). A total of 7 treatment courses were conducted with an interval of 10 days for 6 months. Production trials of the experimental drug “NanoViroSan” against reproductive and respiratory syndrome in association with parvovirus infection of pigs showed its high efficiency at the level of 95.8% in the recovery from reproductive pathology and reduction of massive abandonment of newborn piglets. The use of the experimental drug “NanoViroSan” allows to increase the safety of young animals and stabilize the epizootic situation regarding reproductive and respiratory syndrome and parvovirus infection of pigs in a permanently disadvantaged farm, which indicates the ability to break the epizootic chain of emergent infection
Analisis Kinerja Keuangan Bank BTPN Syariah Berdasarkan ROA, ROE, BOPO, DAR, dan FDR Periode 2014-2022
Authors: Habibullah (Universitas Muhammadiyah Lampung) Shalahudin , (Universitas Muhammadiyah Lampung) Moh. Fakhrurozi , Saputeri (Universitas Muhammadiyah Lampung) Noorikha Pandayahesti
Published: December 2024

Penelitian ini bertujuan untuk mengetahui dan menganalisis risio keuangan ROA, ROE, BOPO, DAR, dan FDR terhadap kinerja keuangan bank BTPN Syariah dari tahun 2014-2022. Metode penelitian dalam penelitian ini menguganakan deskriptif kualitatif dengan mengambil data publikasi dari laporan tahunan bank BTPN Syariah. Hasil penelitian menunjukan bahwa dari analisis ROA baik, bank BTPN Syariah mampu mengelola laba bersih terhadap aset. Analisi ROE menunjukan keadaan baik, bank BTPN Syariah mampu mengelola laba bersih terhadap ekuitas, dan dari analisis BOPO, DAR, dan FDR menunjukan kinerja keuangan bank BTPN Syariah dalam keadaan baik dan terus meningkat.