bluuebunny/crossref_metadata_2025 huggingface dataset:
Reading-light Color Effect on Intraocular Pressure a pilot study
Authors: Chen Tun-Hao , Tsai Pei-Chung , Sharma Dipanshu , Hsiao Yu-Lun , Peng Bo-Hsun , Yeh Po-Ting , Jou Jwo-Huei
Published: September 2024

Purpose: This study aimed to investigate the effect of reading-light color on intraocular pressure (IOP) and its fluctuation in the dominant and auxiliary eyes.
Design: Correlational research and analysis.
Subjects: Fourteen subjects, aged 20 to 25 years, with a diopter ranging from 0 to -8D, were included.
Method: Subjects were instructed to read a book with a 12-pt text under white light (5,500 K) and candlelight (1,700 K), separately, for 90 minutes. Their intraocular pressures (IOPs) under their own readable brightness were measured by using a tonometer (NIDEK NT-530P) every 30 minutes. The readable brightness, reading-light spectrum and the corresponding maximum permissible exposure-limit (MPE) were measured using a blue-hazard quantitative spectrometer (SRI-100).
Main Outcome Measure: IOP of subjects after reading books under white light and candlelight for 90 minutes.
Results: Colors of reading light indeed had profound effects on IOP, and their effects were very different for the dominant and auxiliary eyes. Under white light, the IOP in the dominant eye barely increased (P=0.6), but fluctuated significantly with the increase in reading time (P=0.04). In contrary, in the auxiliary eye, it did not fluctuate (P=0.28). Instead, it slowly increased with time (P=0.01, r=0.982).
Under candlelight, the IOP also fluctuated in the dominant eye, but to a less significant extent (P=0.045). Moreover, in the auxiliary eye, it did not increase, but gradually decreased with the increase in reading time (P=0.001, r=-0.997).
Furthermore, myopic diopter showed effects on the IOPs of both dominant and auxiliary eyes. In general, the IOP increased with the increase in myopic diopter. For subjects with mild or moderate myopia, the IOP in the dominant eye, either under white or candlelight, barely increased as the reading time increased, indicating a better IOP adjusting ability. As to the subjects with high myopia, their IOP increased with the increase in reading time, with a P value of 0.08 under white light and 0.05 under candlelight.
Conclusion: Different reading-light colors showed significantly different effects on IOP. Reading under blue-emission-free candlelight can effectively prevent the increase in IOP and reduce its fluctuation. Myopic diopter showed effects on the IOPs of both dominant and auxiliary eyes. In general, the IOP increased with the increase in myopic diopter.
Clinical trial registration: 110-136-F, 28-March-2023
Implications of Patient Miscentering on CT Scan Radiation DoseDistribution and Safety: Phantom Study
Authors: HADDA Hassan OU , Zerfaoui Mustapha , KARIM BAHHOUS , YASSINE Oulhouq , Rrhioua Abdeslem , Krim deae-eddine
Published: September 2024

This task highlights the significance of precise patient placement to reduce radiation exposure and maximize diagnostic quality by examining the effects of patient mis-centering on the volumetric computed tomography dose index (CTDIvol) and organ doses during CT scans. Using a CTDI phantom from Sun-Nuclear and an ionization chamber (Radcal, model 10X6-3CT), the research simulated miscentering by shifting the phantom in both vertical and lateral directions. Dose measurements were performed on Philips, FUJIFILM, and Hitachi CT-Scans, maintaining consistent settings. (CTDIvol) and dose ratios at various phantom positions were calculated to assess miscentering effects. The findings demonstrated that (CTDIvol) and peripheral area doses were highly impacted by vertical and lateral miscentering, with vertical miscentering producing dose changes of up to 35% and lateral miscentering lowering (CTDIvol) by as much as 15%. These results emphasize the critical need for proper patient centering in CT scans to ensure accurate dose estimation and reduce radiation exposure.
Synthesis of Fe3O4 encapsulated with lemon yellow for application in magnetic particle inspection
Authors: Liang Zhiqi , Zhang Zhili , Li Decai
Published: September 2024

Magnetic particle inspection, a widely used nondestructive testing method, is employed to detect surface defects in ferromagnetic materials due to its ease of operation, low cost, and high efficiency. In this study, Fe3O4 hollow nanospheres were synthesized by a solvothermal method. Lemon yellow (LY) pigments were successfully encapsulated on the surface of these magnetic nanospheres using E51 epoxy resin. The synthesized Fe3O4/E51/LY composite material was characterized in terms of its microscopic morphology, physical phase, and structural properties. The adsorption mechanism of the fluorescent materials on the particle surface was analyzed. Additionally, the photoluminescence and magnetic properties of the composite were tested and evaluated. A magnetic particle inspection test bench was then established to detect defects in the workpiece. The composite exhibited a saturation magnetization of 53.22 emu/g and emitted yellow-green fluorescence at 525 nm under ultraviolet light. The surface defects of the workpiece were accurately detected using magnetic fluorescent particles.
Anthropometric assessment of the nutritional status of women of childbearing age in the province of Essaouira, Morocco
Authors: Manoussi Abdelmounaim , NACER Nezha , KAJJOUNE Imane , Baali Abdellatif , AMOR Hakima , OUZENNOU Nadia
Published: September 2024

Low- and middle-income countries are facing a rapid increase in nutritional problems, particularly in Africa, where undernutrition, overweight and micronutrient deficiencies coexist, creating a double burden of malnutrition and a challenge to public health policies. In this context, Morocco stands out for its early nutritional transition, characterized by a moderate prevalence of overweight and undernutrition and elevated levels of micronutrient deficiencies. The aim of this study was to assess the nutritional status of women of childbearing age and identify its determinants to suggest ways to improve it. The study was conducted in the province of Essaouira in Morocco, which is characterized by a predominance of rural areas and multidimensional poverty. We conducted a quantitative cross-sectional survey of 1,466 married women of childbearing age via stratified random sampling. Data were collected via questionnaires and anthropometric measurements. Data entry and statistical processing were performed via SPSS® v. 26. The results show that women's nutritional status is worrisome, with an average BMI of 26.4 kg/m². The prevalence of overweight was 61.6% (BMI ≥ 25 kg/m2), with 17.9% of women being obese. Bivariate analysis revealed that age, education level, socioprofessional activity, family structure, household income and parity were significantly associated with overweight. Binary logistic regression confirmed that women's age and level of education are major determinants of overweight/obesity. There is a need to strengthen public health policies aimed at reducing overweight and obesity among women of childbearing age in Morocco, with an emphasis on nutrition education and monitoring their nutritional status throughout their reproductive lives.
Cover crop providing windborne pollen enhances the efficacy of biocontrol of multiple pests by Euseius sojaensis in citrus orchards
Authors: Tsuchida Yuta , Masui Shinichi
Published: September 2024

Euseius species of generalist phytoseiid mites, are effective natural enemies of multiple arthropod pests in various types of orchards worldwide. Cover crops increase the populations of these predators and can help reduce pest populations, but their practical roles and effects in enhancing biological control have not yet been well evaluated. Here, we examined the efficacy of biocontrol of Panonychus citri (McGregor) and Aculops pelekassi (Keifer) by naturally occurring Euseius sojaensis (Ehara) in commercial Japanese citrus orchards with cover crops of Lolium perenne L. managed in two different ways: flowering and mowing. In the flowering plots, the numbers of windborne pollen grains and phytoseiid mites were larger, P. citri populations were smaller, and rates of fruit injury caused by A. pelekassi were significantly lower than in mown plots. In early summer, the number of E. sojaensis in the flowering plots peaked following a peak in the abundance of windborne Poaceae pollen caught on the citrus trees. These results suggest that the windborne pollen supplied from cover crops of L. perenne boost the populations of E. sojaensis inhabiting the citrus trees and enhance the efficacy of biocontrol of P. citri and A. pelekassi. The percentage of E. sojaensis females with eggs was higher in flowering plots than in mown plots. Therefore, in conservation biological control, a ryegrass cover crop flowering in early summer would be beneficial for increasing the fecundity of this predatory mite, even when prey (pest) densities are low.
The Relationship between Teacher-Students Relationships and Academic Grades Among High School Student: The Role of Perceived Teaching Quality and Student's Mental Health Symptoms
Authors: Chen Xiao hui , Bailey Richard , Xie Hong bin , Samsudin Nadia
Published: September 2024

Objective
This study has examined the indirect role of perceived teaching quality in the relationship between TSRs and academic grades, further considered the moderating effects of students' mental health symptoms.
Methods
Utilizing Structural Equation Modelling, this study collected academic grades at three distinct time points to examine the associations among Teacher-Student Relationships, perceived teaching quality, and mental health symptoms with academic grades.
Results
The findings reveal that perceived teaching quality plays a statistically significant indirect role in the relationship between Teacher-Student Relationships and student academic grades. Additionally, the size of this indirect effect is moderated by students' mental health symptoms.
Conclusion
While Teacher-Student Relationships may not be directly associated with students' academic grades, they are significantly linked to perceived teaching quality, which in turn is closely related to academic grades. The extent of this indirect effect is moderated by students' mental health symptoms, suggesting that the relationship between perceived teaching quality and academic grades is influenced by students' mental health status. These findings empirically indicate that Teacher-Student Relationships are important for both teaching and learning activities, underscoring their essential role in improving educational outcomes.
Fault ride through coordination control strategy of direct-drive wind turbine based on reducing energy storage configuration capacity and charge and discharge times
Authors: Wu Haitao , Du Jianbiao , Li Huizhen , ZHang Dan
Published: September 2024

In order to solve the problems of large capacity and frequent charging and discharging of energy storage unit during low voltage traversal of energy storage assisted direct-driven wind turbine, a coordinated control method of wind turbine side, grid side and energy storage side is proposed. Firstly, the mechanism of dc voltage spike caused by voltage sag is analyzed, and the relationship between dc power and ac voltage under fault is deduced, and the coordinated control mechanism is established. Secondly, with the goal of effectively reducing the capacity of flywheel energy storage unit and the frequency of charge and discharge action, three kinds of faults are divided into mild, moderate and severe faults according to the voltage drop degree of power grid. The control modes of wind turbine side, grid side and energy storage side under different faults are analyzed, and a coordinated control strategy among the three is established. Under the premise of low flywheel energy storage capacity, low voltage ride through with different voltage drop depths can be realized, and the charge and discharge times of flywheel energy storage unit can be effectively reduced according to the voltage drop degree of the power grid. The system simulation model is established by using PSCAD/EMTDC, and the simulation results prove that the proposed coordination control strategy is correct and effective.
Response of Seedling Development of Clary Sage (Salvia sclarea L.) to Ethyl Methane Sulfonate (EMS) Applications
Authors: Şenkal Belgin Coşge , USKUTOĞLU Tansu , DOĞAN Hülya
Published: September 2024

This study was carried out to evaluate the effects of ethyl methane sulfonate (EMS) on the emergence rate and seedling characteristics of clary sage (Salvia sclarea) and to lay the foundation for future breeding studies. S. sclarea seeds were kept at 4 different EMS doses (0.25%, 0.50%, 0.75% and 1%) for 4 different durations (6, 12, 24 and 48 hours). Seedlings were grown in the greenhouse. 0.25% EMS concentration was determined as the LD50 dose for S. sclarea used in the research. Among the EMS doses, the highest emergence value (72.00%) was taken from the control application and the lowest value (46.94%) was taken from the 1.00 EMS application. Among the application durations, the highest value (83.30%) gave 12hr, while the lowest value (32.15%) gave 24hr. Considering the Dose x Application Duration interaction, the highest (88.75%) and lowest (1.25%) values ​​were recorded in 0.25% EMS-12hr and 1.00%EMS-48hr applications, respectively. Among the seedling characteristics examined, the highest values ​​for seedling and root length, fresh and dry seedling weight, fresh root weight and leaf length were obtained from the 0.25% EMS-12hr application. The findings obtained from our study showed that as the application time and dose increased, the emergence was negatively affected, and that the EMS application time was more effective than the EMS application dose.
E3 Ubiquitin Ligase FBXO32 Promotes Sepsis-Induced Cardiomyopathy by Regulating ANXA1/PI3K/AKT Signaling
Authors: Chen De , Liang Xuan , Zhang Lei , Zhang Jingjing , Gao Lina , Yan Dong , Zuo Kun , Guo Hong , Du Song , Liu Jian
Published: September 2024

Sepsis-induced cardiomyopathy (SIC) is a severe complication of sepsis. Therefore, understanding SIC pathogenesis and developing new therapeutic targets are of great significance. This study investigated the role of F-box-only protein 32 (FBXO32) in SIC pathogenesis. SIC models were established in rats and H9c2 cells using lipopolysaccharide. The effects of FBXO32 on myocardial apoptosis and mitochondrial structure and function were determined using electron microscopy, reactive oxygen species detection, and JC-1 staining. The molecular mechanism was elucidated using western blotting and co-immunoprecipitation. The results showed elevated FBXO32 expression in both in vivo and in vitro SIC models. FBXO32 knockdown alleviated apoptosis and mitochondrial and cardiac dysfunction. Mechanistic analysis revealed that FBXO32 promoted ubiquitination and degradation of annexin A1 (ANXA1), inhibiting the phosphatidylinositol 3-kinase (PI3K) and protein kinase B (AKT) pathways. Rescue experiments demonstrated that ANXA1 knockdown reversed the effects of FBXO32 knockdown. This study suggests that FBXO32 exacerbates SIC progression by mediating ANXA1 ubiquitination and inhibiting the PI3K/AKT signaling pathway.
Measurement of Bubble Rates in China's A-Share Market and Discussion on Market Efficiency
Authors: yu Zhang
Published: September 2024

Market efficiency and stock market bubble are very much concerned by the academic community. Market efficiency and stock market bubble are two sides of one body, which are both interrelated and opposite to each other. We summarize the development of Efficient Market Hypothesis (EMF), and based on the Residual Income Model (RIM) method, taking the A-share market as an example, analyzes and measures the intrinsic value and stock bubble rate of China's A-share market. The median historical bubble rate of A-shares exceeded 20%, and A-shares were overvalued for most of the statistical period from 2001 to 2019. In the past 30 years of development, China's stock market has not yet built an efficient market mechanism for correcting errors, among which there are human intervention factors such as "policy market", which makes the market price deviate from the intrinsic value of enterprises for a long time. From the perspective of investment, the historical bubble rate of A-shares is significantly negatively correlated with the return on investment (CAGR) in the next five years. The present study examines the measurement of A-share bubble space and market efficiency, providing valuable insights for the development of a more efficient A-share market.
Can a local low-budget intervention make a difference to suicide rates? Evaluating the effectiveness of the Barnet (London) suicide prevention campaign using real-time suspected suicide data
Authors: Chabé-Ferret Bastien , Marzano Lisa
Published: September 2024

Background
Three quarters of suicides in the UK are by men, of which only a quarter had contact with mental health services at the time of their death. Community-based interventions are therefore likely to be crucial to reduce (male) suicides, but there is limited evidence to support their effectiveness. The aim of this study was to evaluate the impact of a multi-strategy campaign to increase uptake of mental health services and peer support amongst working-aged men in Barnet, London.
Methods
We used data on suspected suicides in London between 1st March 2021 to 31st November 2023 (N = 1,408) to calculate monthly age-standardised rates in a) Barnet, b) surrounding boroughs and c) the rest of London, for ‘naïve’ and ‘placebo’ comparisons during and outside the campaign period, and then before, during and after the campaign. We also estimated maximum exposure to the campaign beyond its duration, and repeated the analysis using a more conservative (February to December 2020) baseline period for Barnet.
Results
There was a sizeable drop in suicides in Barnet for the duration of the campaign and the following six months, with 7 to 10 deaths possibly averted thanks to the campaign, which represents a decline of 20 to 30% of the yearly incidence, at a cost of under £5,200 per averted suicide.
Conclusions
Our analysis suggests that a local, relatively inexpensive community-based campaign can be effective in reducing (suspected) suicides. However, further research is needed to confidently link this decrease in suicides to the campaign, or specific elements of it.
Perspective of Mental Health Services Needs and Use in Immigrant Families: An Online Survey
Authors: Hai Tasmia , Sharma Kannvi , Cluett Rachel
Published: September 2024

An online survey of 682 people, 41.3% of whom were immigrants, compared child mental health service needs and use between immigrants and Canadian-born parents. The survey also assessed the expressed need for child mental health support, parental utilization of services, methods of accessing information, and the presence of other support systems. We found a significant underuse of child mental health services among immigrant participants (1.5 times less use) despite a higher reported child need. This disparity was most pronounced in the use of child psychologists, family physicians and other allied health professionals. Results also showed that immigrant and non-immigrant parents used informational platforms at comparable frequencies. An examination of personal support systems showed immigrant parents struggling with their child's mental health and behaviour were less likely to seek support from other Canadians. They also reported less support from their significant other and friends. These findings highlight the importance of considering cultural background in clinical approaches to child mental health and the need for targeted interventions to improve accessibility and utilization of mental health services to ensure health equity.
Variable and insidious respiratory infections: can they be prevented?
Authors: Zaytseva O. V. , Rychkova T. I. , Lokshina E. E. , Shumeiko N. K. , Kulikova E. V.
Published: September 2024

In the practice of a pediatrician, among all detected infectious diseases, acute respiratory infections (ARI) continue to lead. The causes of respiratory infections can be varied. Great importance is attached to the normal microflora, as one of the main regulatory factors that can ensure the adaptation of children to different living conditions, and is responsible for maintaining homeostasis and maturation of the immune system. It has now been established that a healthy oral microbiome is the key to somatic health, and one of the important components of anti-infective protection. Therefore, one of the promising areas for the prevention of respiratory infections is the use of oral probiotics. The article provides an overview of findings from the studies on the efficacy and safety of the probiotic strain Streptococcus salivarius K12 showing inhibitory activities against the main respiratory pathogens – Streptococcus pyogenes, Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis. S. salivarius K12 produces the bacteriocin-like inhibitory substance BLIS K12 (Bacteriocin-Like Inhibitory Substance), which plays an important role in maintaining the natural flora of the upper respiratory tract. It has been proven that the use of S. salivarius K12 results in a reduction of the level of pathogen colonization of the oropharyngeal mucosa, a rapid decline of the clinical symptoms of acute and chronic diseases of the ENT organs, and the prevention of acute respiratory diseases. The reason for this is that the intake of S. salivarius K12 increases the amount of interferon γ in saliva, stimulating the adaptive immunity against many viral infections. S. salivarius K12 is included in the clinical guideline on acute tonsillopharyngitis for the prevention of relapses, as well as the recovery of the normal biota of the oropharyngeal mucosa after disease.
MINORIAS SOCIAIS REPRESENTADAS NA CRÔNICA DE JOÃO DO RIO
Authors: Trindade Rodrigo S. , Matos Angelus Montanari de
Published: September 2024

João do Rio teve destaque na história da crônica no Brasil. Especialmente em A alma encantadora das ruas, coletânea que reúne crônicas escritas entre os anos de 1904 e 1907, durante o período de modernização da cidade do Rio de Janeiro, o narrador descreve a classe popular e menos favorecida que vê nas ruas da Capital Federal da Primeira República. Este texto visa a investigar como as minorias sociais são representadas na obra de João do Rio, estabelecendo como hipótese a de que os narradores desse cronista guardariam relações com o painel mais amplo da crônica brasileira entre o fim do século XIX e o início do século XX.
Trilha dos Sinais: Um Game Lúdico para o Ensino do Alfabeto em LIBRAS
Authors: Abreu Gabriela , Pereira Anrafel
Published: September 2024

A Língua Brasileira de Sinais, conhecida como Libras, é importante para a comunidade surda do Brasil. No entanto, sua baixa utilização cria desafios de comunicação para os surdos. Este artigo propõe um jogo educativo de tabuleiro que ensina o alfabeto em Libras, combinando componentes físicos e digitais. Além disso, é levado em consideração a integração de técnicas de Machine Learning para validar o aprendizado de Libras através do jogo. Resultados iniciais são promissores, com crianças demonstrando interesse genuíno em aprender mais sobre a Língua Brasileira de Sinais, destacando o potencial dessa abordagem lúdica para promover o ensino deste conteúdo para as crianças ouvintes e surdas, enfatizando a importância da inclusão social. No geral, este artigo enfatiza a necessidade de soluções educacionais inovadoras para incentivar o uso de Libras e promover a inclusão social de crianças surdas.
A imunização contra a COVID-19 pela ótica dos usuários do SUS: uma análise netnográfica
Authors: Nascimento Gonçalves Costa Natalí , Santos Barreto Rejane , Pinheiro de Brito Laís , Santos Souza Simone , Silva Servo Maria Lúcia
Published: September 2024

O objetivo desse estudo é apreender sobre a imunização contra a COVID-19 no pela ótica dos usuários do Sistema Único de Saúde. Trata-se de um estudo qualitativo, observacional, do tipo netnográfico realizado no Instagram, no perfil da hashtag (#)VACINAPARATODOS. Foram coletadas 100 publicações, entre os dias 17 a 20 de julho de 2021, distribuídas em 25 publicações por dia. As publicações compuseram um corpus textual, e passou por análise lexical com auxílio do software IRAMUTEQ, originando uma nuvem de palavras e em seguida foi submetido à análise de conteúdo de Bardin. Como resultados emergiram três categorias: Percepção do cenário pandêmico; Expectativas da imunização e esperança de dias melhores; Hesitação vacinal e negacionismo. Observou-se que as percepções são complexas, permeadas por sentimentos de dor, insegurança e sofrimentos, porém mostrou formas de enfrentamento com emoções como alívio e valorização da ciência, mesmo com o negacionismo de alguns brasileiros.
Regulation and Crosstalk of Cells and Factors in the Pancreatic Cancer Microenvironment
Authors: Xu Jia , Lou Songmei , Huang Hui , Xu Jian , Luo Feng
Published: September 2024

Pancreatic cancer is a highly malignant form of cancer that distinguishes itself from other gastrointestinal tumors through significant fibrosis and unique perineural invasion. These characteristics underscore the complexity of neural regulation within the pancreatic cancer Tumor Microenvironment (TME). This review aimed to explore the regulatory mechanisms and crosstalk among stromal cells and their factors within the pancreatic cancer microenvironment. We begin by reviewing the major components of the pancreatic cancer microenvironment, analyzing interactions among crucial cell types, such as Cancer-associated Fibroblasts (CAFs) and immune cells, and revealing the dynamic changes between tumor cells and surrounding nerves, immune, and stromal cells. We discuss the role of neural factors, including the Nerve Growth Factor (NGF) and Brain-derived Neurotrophic Factor (BDNF), in the progression of pancreatic cancer and the mechanisms by which the sympathetic and parasympathetic nervous systems regulate tumor cell growth, migration, and invasion. Interactions among stromal cells, cytokines, and neural factors in the pancreatic cancer microenvironment promote fibrosis and perineural invasion. A deeper understanding of the regulation and crosstalk among components in the pancreatic cancer microenvironment offers new perspectives for inhibiting fibrosis and perineural invasion in pancreatic cancer.
Beyond Insulin: A Deeper Dive into Pancreatic Disease
Authors: Sharma Sumeet , Sharma Prerna , Rani Nidhi
Published: September 2024

There are several different categories into which the etiology of pancreatic disease
can be subdivided, including inflammation, neoplasia, endocrine dysfunction, and genetic disorders.
A comprehensive understanding of the pathogenesis of pancreatitis is necessary for the development
of appropriate management methods and therapies, as the disorder has a complicated
underlying pathophysiology. Complications such as reduced digestive function, the formation of
pseudocysts or abscesses, and ongoing pain are likely as the illness develops. The purpose of
this review is to act as a knowledge base. This study aims to examine existing approaches to
treating diabetes, including both cutting-edge and tried-and-true therapies. Based on the literature
review, the authors discussed how pancreatic failure affected higher animals, explored how
the pancreatic exocrine function affects adult and adolescent organism development, and gave
an overview of all the conditions that directly affect pancreatic health. There was also a discussion
of the link between obesity, lifestyle, nutrition, and pancreatic issues.
Successful Treatment of a Patient with Hepatic Portal Vein Gas after Radiofrequency Ablation of Atrial Fibrillation: A Case Report
Authors: Lu Xuelin , Qin Tao , Zhou Houping , Xiong Gen , Luo Li , Qin Zuoan
Published: September 2024

Background:

Transcatheter radiofrequency ablation is one of the main treatments for atrial fibrillation, but related complications of this surgery are uncommon.

Case Presentation:

Here, we report a 70-year-old elderly male patient with atrial fibrillation who experienced severe abdominal pain early after undergoing
radiofrequency ablation; related imaging examinations suggested that the patient had intestinal edema and thickening, combined with hepatic portal
vein gas accumulation. The reason was that the patient experienced intestinal necrosis due to superior mesenteric artery embolism related to
radiofrequency surgery. The surgeon suggested laparotomy for exploration. However, after multidisciplinary consideration, we ultimately chose
conservative treatment. After fasting, gastrointestinal decompression, spasmolysis, pain relief, somatostatin inhibition of intestinal edema, antiinfection,
and anticoagulation, the patient's condition improved, and he was discharged. We followed the patient for 1 month after discharge, and
there was no special discomfort.

Conclusion:

Hepatoportal vein gas accumulation after radiofrequency ablation of atrial fibrillation is rare, and imaging findings have important guiding
significance for the diagnosis and treatment of the disease.
Progress in the Development of Antifouling Electrochemical Biosensors
Authors: Chen Liuxing , Chen Da , Lian Meiling
Published: September 2024

Electrochemical biosensors a subclass of biosensors, consisting of a biosensing element
and an electrochemical transducer, have been widely used in various fields due to their excellent
performance and portable device. However, in complex actual samples, non-specific adsorption of
proteins and solid particles, and adhesion of cells and bacteria will lead to problems such as reduced
sensor sensitivity, prolonged response time, and expanded detection errors. Therefore, constructing
antifouling sensing platforms to effectively resist the bioadhesion of non-targets is crucial for the
performance of biosensors. This study first introduces the commonly used classifications of electrochemical
biosensors and their main contaminants. It also provides a comprehensive overview of the
construction methods and application research of electrochemical antifouling sensors using different
strategies, including the construction of physical, chemical and biological modification interfaces. In
addition, the research progress on antifouling and antibacterial dual-action coatings for electrochemical
detection is also reviewed. Finally, the challenges and future development trends of various
methods are summarized, providing clues for better practical applications of electrochemical biosensors.
Nano-Rutin: A Promising Solution for Alleviating Various Disorders
Authors: Nautiyal Gunjan , Minocha Neha , Sharma Shiv Kant , Yadav Kiran , Kaushik Dhirender , Pandey Parijat
Published: September 2024

Background:

Rutin, often known as vitamin P, is a natural flavonoid compound, which
offers a broad spectrum of therapeutic potentials. Rutin is metabolised to different compounds by
the gut bacteria after consumption, therefore, very little is absorbed. Higher plants contribute to rutin
synthesis in large quantities, and it may also be found in many fruits and fruity rinds, particularly
citrus fruits and berries.

Objective:

The present paper highlights several studies and patents conducted on rutin along with its
nanoformulations regarding its broad spectrum of therapeutic potentials

Method:

Numerous electronic databases, including Springer, PubMed, Science Direct, Pubchem,
Google Patents etc. were searched to extract relevant published literature demonstrating rutin effectiveness
in various ailments.

Results:

The reviewed literature showed that rutin and related flavonoids possess a variety of physiological
properties that protects human beings, plants and animals. Antioxidant, anti-inflammatory,
anti-allergic, cytoprotective, vasoprotective, anticarcinogenic, neuroprotective, cardioprotective, antibacterial,
antiviral, antiprotozoal, antitumor, anti-hypertensive antiplatelet, antispasmodic and hypolipidemic,
activities. Nanotechnology has been implemented for the improvement of the bioavailability
of rutin using novel drug-delivery carriers.

Conclusion:

The study concludes that the development of rutin nanoformulations for multiple therapeutic
approaches contributes towards enhanced aqueous solubility as well as tailored pharmacokinetics
compared to conventional delivery of rutin. However, more investigations should be conducted
to confirm the improved bioavailability of the rutin nanoformulations.
PENGARUH PENDAPATAN ASLI DAERAH DAN DANA OTONOMI KHUSUS TERHADAP INDEKS PEMBANGUNAN MANUSIA MELALUI BELANJA MODAL SEBAGAI VARIABEL MODERATING
Authors: Nanda Rizky , Moh. Khusaini
Published: September 2024

Humans are any region’s main source of development. Therefore, improvement on their quality, which is measured through Human Development Index (HDI), is necessary. Cities and regencies in Papua city are high in discrepancy concerning the said index. Therefore, the roles of the government as the policy makers are crucial. The objective of this research is to identify the effects of local own-source revenue and special autonomy funds on HDI with capital expenditures as the moderating variable. This research uses secondary data from 29 regencies and cities in Papua province, from 2017 to 2021 and was analyzed through panel data regression with interaction. The hypothesis testing and the model feasibility assessment were conducted using t-test, F-test, and coefficient of determination test. This study finds that local own-source revenue, special autonomy funds, and capital expenditures negatively and significantly influence HDI. Furthermore, capital expenditures as the moderating variable were found to strengthen the partial effects of local own-source revenue and special autonomy funds to HDI. Finally, this research is expected to serve as evaluation material and reference for the government in its policy-making processes and to enrich the treasury of knowledge in financial literacy.
Evaluasi Pengelolaan Limbah Bahan Berbahaya dan Beracun (B3) di Suatu Pembangkit Listrik Tenaga Gas dan Uap (PLTGU), Kota Palembang
Authors:   Institut Teknologi Bandung, Chaerul Mochammad , Milenia Desmonda Fitri ,   Institut Teknologi Bandung
Published: September 2024

Energi, terutama dalam bentuk listrik merupakan salah satu kebutuhan esensial bagi manusia. Untuk memproduksi listrik dibutuhkan berbagai macam proses, termasuk melalui kombinasi pembangkitan tenaga gas dan uap. Dalam proses produksi, suatu Pembangkit Listik Tenaga Gas dan Uap (PLTGU) menghasilkan berbagai macam jenis limbah, diantaranya yang terkategori sebagai limbah Bahan Berbahaya dan Beracun (B3). Studi ini bertujuan untuk mengidentifikasi sumber timbulan dan mengevaluasi pengelolaan limbah B3 di suatu PLTGU di Kota Palembang, Sumatera Selatan. Metode yang digunakan berupa observasi detail dan analisis kepatuhan pengelolaan limbah B3 berdasarkan peraturan perundangan yang berlaku. Selama masa observasi, limbah B3 yang dihasilkan berupa minyak pelumas bekas atau oli bekas, sludge oil, kain majun bekas, kemasan bekas B3, filter bekas dari fasilitas pengendalian pencemaran udara, limbah terkontaminasi, sludge IPAL, dan limbah kimia hasil analisis laboratorium. Secara umum, PLTGU tersebut telah melakukan pengelolaan limbah B3 dengan memadai, terutama di tahapan pelabelan, pengemasan, dan penyimpanan. Pengangkutan dan pengolahan limbah B3 dikerjasamakan dengan pihak ketiga yang telah memiliki izin terkait. Pengelolaan limbah B3 di suatu industri menjadi penting agar tidak menimbulkan dampak negatif ke lingkungan dan kesehatan manusia.
SINTESIS DAN KARAKTERISASI MEMBRAN POLISULFON DAN SELULOSA ASETAT DARI LIMBAH FILTER ROKOK
Authors: Zulfa Musyaffa Amirah , Fadillah Nurul , Maina Idriss Ibrahim , Agung Nugroho Wahyunanto , Roil Bilad Muhammad , Wibisono Yusuf
Published: September 2024

Membran merupakan salah satu teknologi pengolahan air untuk menyaring partikel-partikel dalam air. Polisulfon (PSf) adalah polimer yang umum digunakan untuk membuat membran ultrafiltrasi. Namun, permasalahan utama PSf adalah sifatnya yang hidrofobik sehingga menyebabkan rendahnya permeabilitas serta mempercepat terjadinya pengotoran. Selulosa asetat (CA) adalah material hidrofilik yang dapat menimbulkan hidrofilisitas pada membran PSf. Hampir 90% rokok diproduksi dengan filter yang berasal dari CA. Filter rokok mengandung hingga 97% CA yang dapat digunakan kembali sebagai bahan baku pembuatan membran. Fokus dari penelitian ini adalah melakukan sintesis membran melalui pendekatan metode inversi fasa dengan bahan dasar berupa polimer PSf yang dikombinasikan dengan polimer CA dari limbah filter rokok yang diharapkan dapat meningkatkan sifat hidrofilisitas membran. Variasi PSf dan filter rokok (PSf/CA) yang digunakan pada penelitian adalah 100:0, 75:25, 50:50, dan 25:75. Hasil dari membran dilakukan karakterisasi melalui analisis sudut kontak air, analisis permeabilitas membran, serta analisis gugus senyawa selulosa asetat pada membran. Nilai sudut kontak statis membran berturut-turut adalah 126,754º, 83,291º, 80,223º, 71,929º. Permeabilitas air bersih membran masing-masing adalah 4.145 L/m2.h.bar, 3.125 L/m2.h.bar, 13.145 L/m2.h.bar, dan 7.187 L/m2.h.bar.
Retrobulbarni hemangiom kod prijevremeno rođenog djeteta
Authors: Marš Lucija , Čaljkušić-Mance Tea , Alpeza Dunato Zvjezdana , Gržetić Lenac Renata , Mrak Maja
Published: September 2024

Cilj: Prikazati rijetku lokalizaciju hemangioma u prijevremeno rođenog djeteta te ukazati na važnost ranog početka liječenja kako bi se spriječile moguće komplikacije. Prikaz slučaja: Prijevremeno rođeno žensko dijete upućeno je na konzilijarni pregled kod oftalmologa zbog edema gornje vjeđe lijevog oka te protruzije bulbusa u trajanju tri tjedna. Fizikalnim pregledom ustanovljena je blaga aksijalna, bezbolna proptoza lijevog bulbusa, palpebralni edem te sporiji zjenični odgovor. Učinjeni su nativni i postkontrastni MR te UZV B scan bulbusa i retroorbitalnog prostora. MR je ukazao na protruziju lijevog bulbusa uvjetovanu hemangiomom uz lateralnu konturu i krov orbite koji imprimira okolne mišiće te s mjestimičnim znakovima intrakonalnog širenja u područje posteriornog dijela orbite. Uočeno je širenje i kroz gornju orbitalnu fisuru do razine regije kavernoznog sinusa. Započeta je terapija propranololom. Nakon tri mjeseca od početka terapije UZV i MR pokazali su potpuno povlačenje tumorske tvorbe. Zaključak: Retrobulbarni hemangiomi zbog svoje lokalizacije mogu uzrokovati brojne teške komplikacije pa je potrebno što ranije dijagnosticiranje i početak liječenja kako bismo spriječili komplikacije. Zbog ograničenosti u terapijskom izboru, lijek prvog izbora je oralni propranolol.
Machine Learning Prediction Models for Recovery After Colorectal Cancer Surgery Using Wearable Device Data, Air Quality Data, and Clinical Evaluation Data (Preprint)
Authors: Liao Yu-Tso
Published: September 2024

BACKGROUND

With the advancement of medical technology, minimally invasive surgery has gradually replaced traditional surgery as the primary treatment for colorectal cancer because of its more minor wound and shortened length of hospitalization. The subject of our research is how to investigate the postoperative recovery status further on this basis.

OBJECTIVE

The study hopes to use the physiological and clinical data combined with the patient's lifestyle indicators and use machine learning models to predict the patient's postoperative recovery.

METHODS

A total of 85 patients, data had been collected from National Taiwan University Hospital and National Taiwan University Hospital Hsinchu Branch, undergoing minimally invasive surgery for colorectal cancer. We use wearable devices to collect the participant's step count data, select the nearest station according to their location to collect the PM2.5 in the air quality index of the day as environmental data and merge the two lifestyle indicators above with physiological and clinical data to predict. We use postoperative complications, defined by the Clavien-Dindo classification, as the basis for judging the situation of postoperative recovery. Four data pre-processing methods and six machine learning classification models were used to predict, and each feature was discussed in an interpretable model SHAP.

RESULTS

In each data set and machine learning model, the performance of the third data set trained with Random Forest and the performance of the fourth data set trained with XgBoost are better. Based on the results, we found that the model tended to predict a good recovery on the participants with more steps/day than 2,000 and low sub-index of PM2.5 in their living environment.

CONCLUSIONS

Combined with the patient's physiological and clinical data, step counts, and air quality data, through the data pre-processing, machine learning prediction, and interpretable model analysis, the merged data are used to classify the participants' postoperative recovery status. We found that if the patient had a daily essential exercise (based on the number of steps, more than 2,000 steps per day) in an environment where PM2.5 is low (PM2.5 sub-index is less than 36), it would help Postoperative recovery.
Functional Zoning of Urbanized Territories of the North-Eastern Caucasus for Recreational Purposes
Authors: Zaburaeva Khava , Zaburaev Chingizkhan , Sedieva Milana , Shaipova Aminat
Published: September 2024

The article presents the results of comparative analysis of the main geourbanistic processes in the North-Eastern Caucasus. Modern concepts and approaches in the works of Russian and foreign researchers to the functional zoning of urban areas as the most important tool for their regulation and management are revealed. The period 1986–2023 reveals a significant increase in the area of built-up territories in large cities. The most active rates of construction occurred in Makhachkala and Grozny. In the larger cities considered in the article, the last decade has seen an increase in the area of residential and public-business zones. The current structure of land funds in Makhachkala and Nazran is dominated by agricultural land, while Grozny also has a high share of residential area. It is shown that the areas of recreational zones in the cities under study are insufficient both to meet the recreational needs of residents and for the development of tourism. It is proved that it is necessary to increase the area of recreational zones at the expense of agricultural land, and in Grozny also by reducing the industrial-engineering zone. Assessment of the areas of urban forested territories and their cartographic visualization revealed an insufficient level of greening and uneven distribution of forest areas. Very low level of greening was found in Nazran (less than 1%) and Makhachkala (6%). Taking into account the identified features and trends in the ratio of functional zones in large cities of the North-Eastern Caucasus, recommendations are given to optimize functional zoning by regulating the ratio of functional zones, green spaces, including vertical landscaping, introduction of elements of creative linguistic landscapes. Special attention is paid to providing a diversity of recreational areas.
MANAJEMEN ANESTESI PADA PASIEN PATENT DUCTUS ARTERIOSUS DENGAN HIPERTENSI PULMONAL BERAT DAN REGURGITASI TRIKUSPID BERAT
Authors: Sugiarto Tomi , Rachman Iwan Abdul
Published: September 2024

Patent ductus arteriosus (PDA) merupakan penyakit jantung bawaan asianotik yang didefinisikan sebagai persistensi dari pintasan janin antara arteri pulmonalis dan aorta, menyebabkan terjadinya oversirkulasi pulmoner dan hipoperfusi sistemik. Pasien PDA yang menjalani operasi nonkardiak memiliki resiko morbiditas dan mortalitas yang tinggi. Kondisi diperberat dengan adanya hipertensi pulmonal yang diketahui memberi kontribusi kasus henti jantung perioperatif, dan regurgitasi tricuspid menimbulkan overload volume ventrikel kanan dan meningkatkan resiko gagal jantung kanan.
Dilaporkan satu kasus multiple karies dengan PDA disertai hipertensi pulmonal berat dan regurgitasi tricuspid berat pada anak usia 6 tahun yang akan menjalani operasi mouth preparation. Pasien datang dengan keluhan gigi berlubang sejak 1 tahun, disertai dengan sesak nafas dan batuk. Pemeriksaan fisik menunjukkan adanya peningkatan denyut nadi dan laju nafas disertai dengan penurunan saturasi oksigen perifer, bunyi jantung tambahan dan clubbing finger disertai akral cyanosis. Foto rontgent thoraks menunjukkan kesan kardiomegali disertai bronkopneumonia bilateral dd/ edema paru perbaikan, efusi pleura kiri perbaikan. Hasil echokardiografi didapatkan PDA 7-8 mm bidirectional shunt, RV dan RA dilatasi dengan TR severe, dengan EF 52,6%. Pasien dikategorikan status ASA III. Pasien diberikan premedikasi intravena dengan midazolam 0,5 mg, dilakukan anestesi umum, preoksigenasi dengan oksigen 100%, diinduksi secara intravena dengan fentanyl 35 mcg dan midazolam 3 mg, dan diberikan pelumpuh otot atracurium 6 mg. Pasien diintubasi dengan menggunakan endotracheal tube no. 5,0. Saat operasi diberikan rumatan anestesi dengan sevoflurance 2-3vol% dalam O2:udara. Paska operasi pasien dipindahkan ke ruang semiintensif dengan oksigenasi nasal kanul dan diberikan analgetik berupa paracetamol 240mg/6 jam secara intravena dan ketoprofen supositoria 25mg.
Operasi dengan kondisi PDA, hipertensi pulmonal berat dan perlu dipastikan agar tercapai keseimbangan aliran darah, sehingga tidak terjadi peningkatan aliran darah pulmonal yang dapat menyebabkan desaturasi dan penurunan perfusi oksigen ke jaringan. Ventilasi perlu diberikan secara cukup; tidak hipoventilasi yang memicu peningkatan PVR, dan tidak berlebihan agar menghindari overdistensi alveolar yang dapat berakibat meningkatkan tekanan arterial paru. Anestesi umum menjadi pilihan agar tercapai kontrol ketat oksigenasi dan ventilasi.
Penggunaan Magnesium sulfat pada pasien dengan asma persisten sedang menjalani operasi elektif tiroidektomi total
Authors: Tyastarini Ni Putu Ade Tiwi , Perdana Aries
Published: September 2024

Ilustrasi Kasus : Perempuan, 45 tahun, dengan riwayat asma persisten sedang, diabetes mellitus tipe 2, dan struma multiple nodusa nontoksik (SMNT) bilateral, rencana akan menjalani prosedur tiroidektomi total. Saat dilakukan kunjungan pra anestesi, didapatkan kondisi pasien dalam kondisi eksaserbasi akut, kemudian malam hari sebelum prosedur operasi, pasien diberikan inhalasi salbutamol 2,5 mg dan budesonide 0.25mg. Saat di ruang penerimaan diberikan Magnesium sulfat (MgSO4) 25 mg/kgbb IV dalam larutan NaCl 0.9% 100ml drip dalam 10 menit, dan dilanjutkan pemberian rumatan MgSO4 5 mg/kgbb/jam intraoperatif. Pasca operatif pasien dilakukan ekstubasi dalam dan dilakukan pemantauan di ICU selama < 24 jam, dan dilanjutkan perawatan ruangan hingga diperbolehkan rawat jalan pada hari kedua pascaoperasi.
Diskusi: Pada operasi elektif terutama di area jalan napas, resiko terjadinya bronkospasme akan meningkat dan diperlukan penanganan perioperative yang optimal terutama pada pasien dengan komorbid asma. Pemberian magnesium sufat mempunyai beberapa keuntungan dalam kasus ini, ditinjau dari efek bronkodilatasi yang dihasilkan, sebagai adjuvant analgesia dan juga terapi hipomagnesemia terkait diabetes mellitus. Sebagai kesimpulan MgSO4 dapat digunakan sebagai alternatif dalam modalitas anestesi pasien dengan riwayat asma persisten sedang yang akan mejalani operasi.
CONTRIBUCIÓN AL CONOCIMIENTO DE LA DIETA DE Dipsas variegata (SERPENTES: COLUBRIDAE)
Authors: Gómez Fonseca Ely David
Published: September 2024

Se aportan datos acerca de los hábitos alimentarios de Dipsas variegata.
DIVING BEHAVIOR IN THE NEOTROPICAL WHIPSNAKE Chironius carinatus FITZINGER, 1826 (Serpentes: Colubridae)
Authors: Angarita Sierra Teddy , Loperena Osnaider , Jimenez Quintero Wilfran Antonio , Rangel Mayra Alejandra , Carrillo Pacheco Onasis Eliam , Gonzalez Ramirez Yenny Paola , Sanchez Pacheco Santiago Jose
Published: September 2024

We document for the first time diving behavior and long-term immersion (> 15 minutes) for the Neotropical whipsnake Chironius carinatus. This report is from the Sierra Nevada de Santa Marta, Cesar department, northern Colombia, and highlights that knowledge of the habits and habitat use of this conspicuous snake remains fragmentary.