bluuebunny/crossref_metadata_2025 huggingface dataset:
Associations Between Daily-Use Products and Urinary Biomarkers of Endocrine-Disrupting Chemicals in Adults of Reproductive Age
Authors: Foley Jayne Marie , Kwiatkowski Carol F. , Rochester Johanna R. , Neveux Iva , Dabe Shaun , Lathrop Michael Kupec , Daza Eric J. , Grzymski Joseph J. , Greenfield Ben K. , Hua Jenna
Published: January 2025

Background: Daily-use products, including personal care products, household products, and dietary supplements, often contain ingredients that raise concerns regarding harmful chemical exposure. Endocrine-disrupting chemicals (EDCs) found in daily-use products are associated with numerous adverse health effects. Methods: This pilot study explores the relationship between concentrations of EDCs in urine samples and products used 24 h prior to sample collection, and ingredients of concern in those products, in 140 adults of reproductive age in Northern Nevada. Results: Having higher numbers of products and ingredients of concern, especially in the personal care category, was associated with higher levels of mono-(-ethyl-5-carboxypentyl) phthalate (MECPP). Similarly, taking more supplements was associated with higher levels of methylparaben (MePB). In contrast, using household products with more ingredients of concern was associated with lower levels of monobutyl phthalate (MBP). Generally, women used more products, were exposed to more ingredients of concern and had higher urinary metabolites than men. Participants who rated themselves as being in poor/fair health were exposed to more personal care and supplement ingredients of concern than those in better health. Interestingly, those in excellent health also took supplements with more ingredients of concern. Conclusions: Greater product use and more ingredients of concern are associated with urinary metabolites of known EDCs and self-ratings of poor health. Women and people who take supplements are at greater risk, and even people who consider themselves to be healthy can be highly exposed. More education among the general public is needed to make people aware of the presence of these chemicals in their everyday products so they can make efforts to avoid them.
Exploring the Pharmacogenomic Map of Croatia: PGx Clustering of 522-Patient Cohort Based on UMAP + HDBSCAN Algorithm
Authors: Brlek Petar , Bulić Luka , Mršić Leo , Sokač Mateo , Brenner Eva , Matišić Vid , Skelin Andrea , Bach-Rojecky Lidija , Primorac Dragan
Published: January 2025

Pharmacogenetics is a branch of genomic medicine aiming to personalize drug prescription guidelines based on individual genetic information. This concept might lead to a reduction in adverse drug reactions, which place a heavy burden on individual patients’ health and the economy of the healthcare system. The aim of this study was to present insights gained from the pharmacogenetics-based clustering of over 500 patients from the Croatian population. The data used in this article were obtained by the pharmacogenetic testing of 522 patients from the Croatian population. The patients were clustered based on the genotypes of 28 pharmacologically relevant genes. Dimensionality reduction was employed using the UMAP algorithm, after which clusters were defined using HDBSCAN. Validation of clustering was performed by decision tree analysis and predictive modeling using the RandomForest, XGBoost, and ExtraTrees classification algorithms. The clustering algorithm defined six clusters of patients based on two UMAP components (silhouette score = 0.782). Decision tree analysis demonstrated CYP2D6 and SLCO1B1 genotypes as the main points of cluster determination. Predictive modeling demonstrated an excellent ability to discern the cluster of each patient based on all genes (avg. ROC-AUC = 0.998), CYP2D6 and SLCO1B1 (avg. ROC-AUC = 1.000), and CYP2D6 alone (avg. ROC-AUC = 0.910). Membership in each cluster provided clinically relevant information, in the context of ruling out certain favorable or unfavorable phenotypes. However, this study’s main limitation is its cohort size. Through further research and investigation of a larger number of patients, more accurate and clinically applicable associations between pharmacogenetic genotypes and phenotypes might be discovered.
Enhancing Soybean Salt Tolerance with GSNO and Silicon: A Comprehensive Physiological, Biochemical, and Genetic Study
Authors: Msarie Meshari Winledy , Methela Nusrat Jahan , Islam Mohammad Shafiqul , An Tran Hoang , Das Ashim Kumar , Lee Da-Sol , Mun Bong-Gyu , Yun Byung-Wook
Published: January 2025

Soil salinity is a major global challenge affecting agricultural productivity and food security. This study explores innovative strategies to improve salt tolerance in soybean (Glycine max), a crucial crop in the global food supply. This study investigates the synergistic effects of S-nitroso glutathione (GSNO) and silicon on enhancing salt tolerance in soybean (Glycine max). Two soybean cultivars, Seonpung (salt-tolerant) and Cheongja (salt-sensitive), were analyzed for various physiological, biochemical, and genetic traits under salt stress. The results showed that the combined GSNO and Si treatment significantly improved several key traits, including plant height, relative water content, root development, nodule numbers, chlorophyll content, and stomatal aperture, under both control and salt stress conditions. Additionally, this treatment optimized ion homeostasis by enhancing the Na/K ratio and Ca content, while reducing damage markers such as electrolyte leakage, malondialdehyde, and hydrogen peroxide. The stress-responsive compounds, including proline, ascorbate peroxidase, and water-soluble proteins, were elevated under stress conditions, indicating improved tolerance. Gene expression analysis revealed significant upregulation of genes such as GmNHX1, GmSOS2, and GmAKT1, associated with salt stress response, while GmNIP2.1, GmNIP2.2, and GmLBR were downregulated in both varieties. Notably, the salt-sensitive variety Cheongja exhibited higher electrolyte leakage and oxidative damage compared to the salt-tolerant Seonpung. These findings suggest that the combination of GSNO and silicon enhances salt tolerance in soybean by improving physiological resilience, ion homeostasis, and stress-responsive gene expression.
Effects of the Interactions Between Food Additive Titanium Dioxide and Matrices on Genotoxicity
Authors: Jeong Su-Min , Nam Han-Na , Choi Soo-Jin
Published: January 2025

Titanium dioxide (TiO2), a white color food additive, is widely used in bakery products, candies, chewing gums, soups, and creamers. Concerns about its potential genotoxicity have recently emerged, particularly following the European Union’s ban on its usage as a food additive due to its genotoxicity potential. Conflicting in vitro and in vivo results regarding its genotoxicity highlight the need for further in-depth investigation. Moreover, food additives can interact with food components or biological matrices, potentially altering their biological responses and genotoxicity. In this study, we evaluated the interactions between two different sizes of additive TiO2 particles and food or biological matrices, including albumin, fetal bovine serum (FBS), and glucose. The results showed that the hydrodynamic diameters of TiO2 increased upon interaction with albumin or FBS, but not with glucose. The presence of albumin or FBS reduced TiO2-induced cytotoxicity, oxidative stress, in vitro intestinal transport, and ex vivo intestinal absorption to untreated control levels, regardless of particle size. While TiO2 caused DNA damage in intestinal Caco-2 cells, the interactions with albumin or FBS significantly reduced the DNA damage to levels comparable to untreated controls. The DNA damage was closely related to oxidative stress caused by TiO2. These findings suggest that the interaction of TiO2 with albumin or FBS, resulting in increased hydrodynamic diameters, mitigates its cytotoxicity, oxidative stress, intestinal transport, and genotoxicity. Further investigation is required to fully understand the potential genotoxicity of TiO2 in food contexts.
Self-Applied Daylight Photodynamic Therapy: A Paradigm Shift?
Authors: Garcia-Mouronte Emilio , Naharro-Rodriguez Jorge , Alonso-Mtz de Salinas Luis , Pérez-González Luis Alfonso , Fernández-Guarino Montserrat
Published: January 2025

Photodynamic therapy (PDT) involves the topical application of a photosensitizer and its activation by visible light, leading to the generation of protoporphyrin IX (PpIX) and reactive oxygen species. Daylight photodynamic therapy (dPDT), a variant utilizing natural sunlight as the energy source, enhances procedural flexibility by eliminating the need for specialized equipment. dPDT has been effectively used in dermatology to treat various cutaneous disorders, including neoplastic and infectious diseases. Traditionally, skin preparation and photosensitizer application are performed by trained practitioners, limiting the accessibility of dPDT for broader populations. However, recent studies suggest that these preparatory steps can be managed by patients or caregivers, enabling fully self-applied, home-based dPDT protocols. This review systematically examines the current evidence on self-applied dPDT (SA-dPDT), emphasizing molecular mechanisms and its efficacy in managing premalignant and other cutaneous conditions.
A Review on the Nomenclature and Taxonomy of the Old World Thread-Legged Bug Genus Pleias (Hemiptera: Reduviidae: Emesinae)
Authors: Chen Zhuo , Li Hu , Cai Wanzhi
Published: January 2025

The nomenclatural and taxonomic issues regarding the thread-legged bug genera Pleias Kirkaldy, 1901 and Bagauda Bergroth, 1903 are reviewed, and Pleias is concluded to be the valid name of the genus. A comprehensive review of Pleias is conducted, resulting in 18 new combinations and two new synonymies [P. aelleni (Villiers, 1970) comb. n., P. atypica (Ghate, Boyane & Joshi, 2019) comb. n., P. avida (Bergroth, 1903) comb. n., P. brunnea (McAtee & Malloch, 1926) comb. n., P. cavernicola (Paiva, 1919) comb. n., P. creppei (Lhoste, 1939) comb. n. = Bagauda gilletti Miller, 1956 syn. n., P. ernstmayri (Kulkarni & Ghate, 2016) comb. n., P. furcosa (Ribes, 1987) comb. n., P. gigantea (Lhoste, 1939) comb. n., P. lucifuga (McAtee & Malloch, 1926) comb. n., P. monodi (Villiers, 1972) comb. n., P. similis (Wygodzinsky, 1966) comb. n., P. smithersi (Wygodzinsky, 1966) comb. n., P. splendens (Distant, 1906) comb. n., P. strinatii (Villiers, 1970) comb. n., P. tenebricola (Horváth, 1910) comb. n., P. wagneri (Villiers, 1949) comb. n. = B. eriksoni Miller, 1954 syn. n., and P. zetteli (Rédei, 2005) comb. n.]. The bibliographies, diagnosis, and known distribution records are presented for all described species, and three new species [P. fashengisp. n. (from Yunnan, China), P. serratasp. n. (from Sabah, Malaysia), and P. trimaculatasp. n. (from Sulawesi, Indonesia)] are described. The identification keys to the African and Asian species of Pleias are provided. The systematic relationships, distribution, and ecology of the genus are discussed.
Gait Analysis in Patients After Hemiepiphysiodesis Due to Valgus or Varus Knee Deformity
Authors: Leyko Paweł , Zaborska Monika , Walczak Agnieszka , Tomczyk Łukasz , Pelc Marcin , Mnich Aleksander , Operacz Radosław , Morasiewicz Piotr
Published: January 2025

Background: Developmental knee joint deformities are a common problem in pediatric orthopedics. Children with a valgus or varus deformity of the distal femur or the proximal tibia are commonly treated with hemiepiphysiodesis. Gait analysis in patients with lower limb deformities plays an important role in clinical practice. The purpose of our study was to assess gait parameters in patients who underwent hemiepiphysiodesis procedures of the distal femur or proximal tibia due to a knee deformity and to compare them with those in healthy controls. Methods: We prospectively evaluated 35 patients (14 females and 21 males) after hemiepiphysiodesis and compared the results with a healthy control group (26 participants). Gait was analyzed with a G-Sensor device (BTS Bioengineering Corp., Quincy, MA, USA). We assessed the following gait parameters: gait cycle duration, step length, support phase duration, swing phase duration, double support duration, single support duration, cadence, velocity, and step length. We assessed these gait parameters in a group of patients before and after treatment with hemiepiphysiodesis. We compared the patients’ results before and after treatment to those of a healthy control group. The level of significance was set at p < 0.05. Results: The mean follow-up period was 13 months. There was no difference in the results of gait assessments in patients prior to and after treatment. The median step length was 47.09% in the treated limb after treatment and 54.01% in the intact limb (p = 0.018). There were no other differences in gait parameters in the treated limbs and the healthy, intact limbs in the patient group after treatment. There were no significant differences in the patients before and after treatment compared with those in the healthy control group in all gait parameters. Conclusions: Valgus or varus knee deformity correction with the use of hemiepiphysiodesis does not significantly improve preoperative gait parameters. The biomechanical outcomes of hemiepiphysiodesis in the treatment of valgus or varus knee deformity are good. We observed no differences in gait cycle duration, step length, support phase duration, swing phase duration, double support duration, single support duration, gait velocity, cadence, or step length between the experimental and healthy control groups.
Acceptance of the Disease in Patients Diagnosed with Neovascular Age-Related Macular Degeneration Depending on Visual Parameters—Before and After a Series of Seven Intravitreal Injections
Authors: Nowak Marta , Cybulska Anna Maria , Schneider-Matyka Daria , Grochans Elżbieta , Walaszek Ireneusz , Panczyk Mariusz , Nowicki Grzegorz Józef , Rachubińska Kamila
Published: January 2025

Background: Age-related macular degeneration (AMD) is a progressive, chronic eye disease with no permanent cure currently available. Symptoms of the disease, including distorted and blurred vision and gradual loss of central vision, significantly aggravate patients’ daily functioning. The purpose of this study was to assess the acceptance of the disease among patients diagnosed with neovascular age-related macular degeneration before treatment and after receiving seven intravitreal injections and to determine how it was related to the values of visual parameters. Methods: This survey-based study was carried out using the author’s questionnaire and a standardized research tool, the Acceptance of Illness Scale (AIS). It also involved the analysis of the patients’ medical records. Results: The study included 121 patients (121 eyes), including 60 women and 61 men. The age range of the participants was 51–90 years. The mean and median age of the participants was 75 years. After undergoing a series of intravitreal injections, statistically significant improvements were observed in the degree of illness acceptance according to the AIS score. Data analysis revealed that the degree of disease acceptance was significantly related to visual acuity and contrast sensitivity. Conclusions: The acceptance of the disease among the study participants from the beginning of the therapy until receiving a series of seven intravitreal injections was at an average level. Acceptance of the disease was better before the beginning of the therapy, due to higher values of corrected visual acuity, and after the therapy, because of higher values of contrast sensitivity and corrected visual acuity.
Predictive Diagnostic Power of Anthropometric Indicators for Metabolic Syndrome: A Comparative Study in Korean Adults
Authors: Park Jongsuk , Byun Yonghyun , Kim Sangho
Published: January 2025

Background/Objectives: Metabolic syndrome (MetS) is a cluster of risk factors that significantly increase the risk of cardiovascular disease, including type 2 diabetes, etc. Assessing the predictive diagnostic power of anthropometric indicators for MetS is crucial for the early identification and prevention of related health issues. This study focuses on the Korean adult population while providing insights that may be applicable to broader global contexts. Therefore, this study aimed to compare the predictive diagnostic capabilities of various anthropometric indicators, including body mass index (BMI), waist-to-height ratio (WHtR), muscle mass-to-fat mass ratio (MFR), muscle mass-to-waist ratio (MWR), and body shape index (ABSI), in relation to MetS in Korean adults. Methods: Data from 13,725 participants of the Korea National Health and Nutrition Examination Survey (2008–2011) were analyzed. The diagnostic power of each indicator was assessed using the receiver operating characteristic (ROC) curve analysis, and the area under the curve (AUC) values were compared. Participants were classified into normal (NG) and abnormal (AG) groups based on established cutoff values, and logistic regression analysis was performed to evaluate the odds of MetS in each group. Results: WHtR showed the highest AUC values (0.792 for men and 0.768 for women), indicating superior diagnostic accuracy compared to the other indicators (p < 0.001). Logistic regression analysis indicated that both the unadjusted and adjusted odds ratios (OR) for MetS were significantly higher in the AG than in the NG across all indicators (p < 0.001). Specifically, the adjusted OR (95% confidence interval) for WHtR in the AG was 6.793 (5.929–7.784) for men and 4.665 (4.151–5.423) for women, representing the highest values among all indicators (p < 0.001). Conclusion: Among the various anthropometric indicators, WHtR is the most reliable and practical for predicting MetS in Korean adults. It is useful for early intervention and prevention in both clinical and public health settings.
Assessment of Hip Abduction Motion Assistance Using a Single-Joint Hybrid Assistive Limb Robot: Feasibility and Safety Evaluation in Healthy Adults
Authors: Hirose Fumi , Nishino Tomofumi , Shimizu Yukiyo , Soma Yuichiro , Haginoya Ayumu , Yasunaga Shota , Shimasaki Koshiro , Watanabe Ryunosuke , Yoshizawa Tomohiro , Mishima Hajime
Published: January 2025

Background/Objectives: Preoperative muscle atrophy leads to persistent gait abnormalities in patients undergoing total hip arthroplasty (THA). Efficient motor learning of the gluteus medius is crucial for their recovery. In this study, a single-joint hybrid assistive limb (HAL) was developed to assist hip abduction. We aimed to evaluate the muscle activity and safety of this device during hip abduction in healthy adults. Methods: Ten healthy adults (five males and five females; mean age, 40.7 years) with no hip disorders performed one set of 30 repetitions of side-lying hip abduction under three conditions: without HAL (pre-HAL), with HAL, and without HAL (post-HAL). Muscle activities of the gluteus medius, gluteus maximus, tensor fasciae latae, rectus femoris, and biceps femoris (expressed as percentage of maximum voluntary contraction [%MVC]); vital signs; hip visual analog scale (VAS); and hip abduction and flexion angles were assessed. The mean values were compared among the conditions. Results: The %MVC of the gluteus medius significantly increased from 52% (pre-HAL) to 75.4% (HAL) and then decreased slightly to 61.6% (post-HAL). No other muscle groups showed significant changes. Vital signs and hip VAS scores showed no significant variation. Although no significant differences were found in the hip abduction and flexion angles, a reduction in the hip flexion angle was observed in the HAL and post-HAL conditions. Conclusions: The hip abduction HAL effectively and safely enhanced gluteus medius activity. Reduction in the hip flexion angle during HAL and post-HAL suggests the possibility of appropriate abduction movements and motor learning effects.
Hormonal and Glycemic Responses During and After Constant- and Alternating-Intensity Exercise
Authors: Spanoudaki Sofia , Maridaki Maria , Chryssanthopoulos Costas , Philippou Anastassios
Published: January 2025

Background/Objectives: Glucose metabolism and hormonal responses are largely affected by exercise intensity, which exhibits an alternating pattern in many sports activities. The aim of this study was to investigate and compare glycemic and hormonal responses during and after exercise of constant (CON) and alternating (ALT) intensity with the same duration and total work. Methods: Ten healthy male volunteers performed two, 60 min cycling exercise bouts in random order: the ALT bout, where exercise intensity alternated between 46.5 ± 1.9% of VO2max for 40 s and 120% of VO2max for 20 s, so the mean intensity was at 105% of the lactate threshold (LT), and the CON exercise bout, where the intensity was constant at 105% of LT (70 ± 4.7% of VO2max). Results: No significant differences were observed in blood glucose concentrations between the two exercise protocols (p = 0.22) or over time at any time point measured, i.e., before, at 30 and 60 min of each exercise bout, and 60 min post-exercise (p > 0.05). Circulating insulin levels decreased significantly over time in both protocols (p < 0.01 and p < 0.05 in ALT and CON, respectively); nevertheless, they did not differ between the exercise protocols (p = 0.45). Similarly, there were no significant differences in serum leptin and prolactin levels between the two protocols (p = 0.77 and p = 0.80 in ALT and CON, respectively); however, circulating levels of leptin decreased at 30 and 60 min of exercise only in CON (p < 0.05) and those of prolactin at 60 min of exercise only in ALT (p < 0.05) compared to pre-exercise values. Conclusions: Cycling exercise of constant or alternating moderate intensity (~70% of VO2max) with the same duration induces similar glycemic but differential over time hormonal responses in healthy males.
Social Vulnerability and Pregnancy Option Counseling in the Setting of Periviable Delivery
Authors: Piltch Gillian , Comfort Lizelle , Krantz David , Jackson Frank , Blitz Matthew J. , Rochelson Burton
Published: January 2025

Background/Objectives: According to the American Academy of Pediatrics and the American College of Obstetricians and Gynecologists, pregnant people facing periviable delivery should be counseled on expected neonatal outcomes and available pregnancy options. The objective of this study is to evaluate if rates of neonatology consultation and pregnancy option counseling for those facing periviable delivery differ based on social vulnerability factors or Social Vulnerability Index (SVI). Methods: This was a retrospective cohort study of patients who delivered at 22 0/7 weeks to 25 6/7 weeks of gestation at two academic medical centers with level III or IV neonatal intensive care units from 2019 to 2022. We analyzed the association between individual-level social vulnerability factors and census-tract-level SVI (released by the Center for Disease Control) and the rates of neonatology consultation and pregnancy option counseling. Results: In 138 periviable deliveries, 70.3% had a neonatology consultation, 92.0% were offered expectant management, 88.4% were offered neonatal full intervention, 41.3% were offered neonatal comfort care, and 44.9% were offered pregnancy termination. The rate at which neonatology consultations were completed and each pregnancy option was addressed did not differ by individual-level social vulnerability factors including race/ethnicity, government insurance, marital status, English proficiency, and parity, or by SVI. Conclusions: While these findings suggest that individual-level social vulnerability factors and SVI do not influence periviability counseling, we did identify gaps in comprehensive periviability counseling. Focus should be placed on increasing the rate of neonatology consultation and discussing the options of neonatal comfort care and pregnancy termination.
Three-Dimensional Printing of Polymer Composites: Manufacturing and Mechanics
Authors: Bernardy Ryan , Liu Yingtao
Published: January 2025

Polymers have been heavily used in manufacturing for decades, and with their use, improvements in the desired materials via composite materials utilizing a polymer matrix have been commonplace. Naturally, the increase in polymer additive manufacturing has come with an increase in interest in additively manufacturing polymer composites. This paper primarily covers the fused deposition modeling (FDM) method, ultraviolet (UV)-cured resin methods, multiple resin printing, and embedded sensors associated with additive manufacturing. In particular, the manufacturing and subsequent effect on material properties compared to unreinforced and unmodified 3D-printed polymers, the tradeoffs required in doing so, and the mechanisms behind these effects are discussed. The manufacturing methodology used or developed and the mechanisms behind these selections are discussed along with insights that could be gathered from material property effects seen across different studies. The mechanisms discussed also focus on the mechanisms between the different materials comprising the composite produced.
Effective CdS:(Ce, Ga) Nanoparticles for Photocatalytic H2 Production Under Artificial Solar Light Exposer
Authors: Poojitha Pedda Thimmula , Dhanalakshmi Radhalayam , Karim Mohammad Rezaul , An Sung Jin , Madhusudana Rao Kummara , Mallem Siva Pratap Reddy , Kim Young Lae
Published: January 2025

To encounter the burgeoning energy demands of the future, it is imperative to focus on the progress of innovative and profitable techniques for hydrogen (H2) evolution, coupled with an enriched stability of photocatalysts. In this work, we have effectually prepared CdS, CdS:Ce, and CdS:(Ce, Ga) nanoparticles through a chemical refluxing method at 120 °C. Comprehensive structural analysis confirmed the effectual incorporation of Ce and Ga ions in the place of Cd2+ in a CdS matrix. Morphology analysis indicates that the prepared samples are irregularly shaped nanoparticles. Chemical analysis confirmed that the Ce and Ga ions incorporated in the Cd site occurred with 3+ and 4+ valence states. All the samples were assessed for H2 production through water splitting via artificial solar light irradiation. Amid all the samples, CdS:(Ce, Ga) nanoparticles portrayed a giant H2 evolution efficacy (3012 µmol h−1g−1) in 300 min, which is 13.9 times larger than that of the bar CdS sample. Thus, we firmly propose that CdS:(Ce, Ga) samples are authentic and potent candidates for efficient photocatalytic H2 production in sterile environments.
Thermal Characteristics Analysis and Experimental Study of Magnetic Fluid in Sealing Gap
Authors: He Xinyue , Li Zhenggui , Qing Jie , Min Jie , Cheng Chuanshi , Shen Changrong
Published: January 2025

The widespread application of magnetic fluid seals in mechanical devices highlights the significant impact of temperature on the stability of these sealing systems. This paper investigates the magnetic field characteristics and thermal properties of magnetic fluid in sealing devices through both numerical simulations and experimental methods. The effects of rotational speed, magnetic fluid solid content, and heating power on the magnetic fluid temperature of the magnetic sealing device were analyzed. The numerical simulation findings indicate that the viscosity the of magnetic fluid significantly contributes to enhanced energy dissipation, while the temperature of the magnetic fluid rises with increasing rotational speed. The initial-phase transition point of the magnetic fluid and its correlation with phase transition volume relative to shaft rotational speed was determined. The experimental results show that the magnetic fluid temperature rises continuously and the time to reach stability increases with the increase in power, and the same is true for the magnetic fluid with a different solid content. Under the same power, the temperature variation is not large, and the magneto-liquid variation is consistent with that in the numerical simulation. This research provides theoretical insights for designing magnetic fluid sealing devices.
Comparative Study on Hyperelastic Constitutive Models for the Static and Dynamic Behavior of Resilient Mounts
Authors: Park Sung-Ju
Published: January 2025

Resilient mounts play a vital role in anti-vibration and shock-absorption systems, making precise estimation of their static and dynamic stiffness essential for ensuring optimal mechanical performance and effective design. This study investigates the behavior of resilient mounts by analyzing their static and dynamic stiffness characteristics through the application of various hyperelastic constitutive models. Seven hyperelastic models were reviewed and systematically compared using numerical simulations, experimental data, and analytical solutions. The model parameters were calibrated and optimized based on experimental results obtained from quasi-static loading tests, including tension, compression, and shear conditions. Additionally, frequency response simulations were employed to evaluate the dynamic behavior of the resilient mounts under varying preload scenarios. The results provide practical insights into the performance of hyperelastic models and offer a comprehensive guideline for selecting suitable models for resilient mount applications, contributing to improved accuracy in both static and dynamic performance predictions.
Residual Stress in Friction Stir Welding of Dissimilar Aluminum Alloys: A Parametric Study
Authors: Sarfaraz Zulqarnain , Awan Yasser Riaz , Saeed Hasan Aftab , Khan Rehan , Wieczorowski Michał , Din Naveed Akmal
Published: January 2025

Welding-induced residual stress has the capacity to significantly compromise the integrity of mechanical components. Its minimization therefore plays a critical role in the selection of process parameters during the welding process. Friction stir welding is a useful joining technique to weld many materials that are not amenable to the traditional welding techniques. Using a sequentially coupled thermomechanical three-dimensional finite element simulation, this work aimed to quantitatively evaluate the influence of the tool rotational and traverse speeds on the generation of residual stress in the friction stir welding of dissimilar aluminum alloys AA2024−T3 and AA5086−O. The model was validated using established experimental and numerical results. The procedure entailed an initial thermal analysis, the results of which were superposed on a mechanical model to determine the distribution of the residual stress across the welded alloy. The results showed that longitudinal residual stress was dominant as compared to lateral stress. It was also demonstrated that, although the tool rotational speed and the tool traverse speed both affected the post-weld temperature distribution and consequently the longitudinal residual stress, the influence of the former was more substantial. Furthermore, the peak values of the residual stress were found on the retreating side (AA5086−O), making it more critical for the selection of welding process parameters.
Mechanistic Insights into CO2 Adsorption of Li4SiO4 at High Temperature
Authors: Ma Nan , Wei Silin , You Jinglin , Zhang Fu , Wu Zhaohui
Published: January 2025

The development of materials with high adsorption capacity for capturing CO2 from industrial exhaust gases has proceeded rapidly in recent years. Li4SiO4 has attracted attention due to its low cost, high capture capacity, and good cycling stability for direct high-temperature CO2 capture. Thus far, the CO2 adsorption mechanism of Li4SiO4 is poorly understood, and detailed phase transformations during the CO2 adsorption process are missing. Here, aided by in situ X-ray diffraction and in situ Raman spectroscopy, we find that Li4SiO4 reacts with CO2 to form Li2SiO3 and Li2CO3 in CO2 atmosphere at 973 K, with no detectable involvement of crystalline Li2O during the adsorption process. Moreover, we observe a formation of stepped structures in the Li4SiO4 surface after CO2 adsorption by scanning electron microscopy. To illustrate the formation of stepped structures, we propose a modified double-shell mechanism, suggesting a possible two-dimensional nucleation and growth of Li2CO3. This work provides a deeper understanding of the CO2 adsorption mechanism and paves a way for further optimization of Li4SiO4-based adsorbents.
Research Progress on Titanium–Niobium Micro-Alloyed High-Strength Steel
Authors: Zhang Yunshuang , Ma Yuxi
Published: January 2025

Research on micro-alloyed steel is a strategic measure to meet the needs of various industries and promote green development, and it is essential for many major steel-producing countries. Currently, the mainstream micro-alloying elements in the research and application of micro-alloyed steel are V, Ti, and Nb. Due to the high price of V, the actual production is mostly achieved by adding titanium–niobium composite to change the properties of high-strength steel. This article begins by examining the strengthening mechanisms in titanium–niobium micro-alloyed high-strength steel. It then reviews the literature on how metallurgical processes and second-phase particles affect the steel’s properties. The article summarizes the current research status and analyzes the problems in the existing research process and results. Finally, it explores future research directions, offering insights into subsequent studies and applications.
Performance Analysis of a Waste-Gated Turbine for Automotive Engines: An Experimental and Numerical Study
Authors: Cordalonga Carla , Marelli Silvia , Usai Vittorio
Published: January 2025

In this article, the results of an experimental investigation and a 1D modeling activity on the steady-state performance of a wastegated turbocharger turbine for spark ignition engines are presented. An experimental campaign to analyze the turbine performance for different waste-gate valve openings was conducted at the test bench for components of propulsion systems of the University of Genoa. Thanks to the experimental activity, a 1D model is developed to assess the interaction between the flow through the impeller and the by-pass port. Advanced modeling techniques are crucial for improving the assessment of turbocharger turbines performance and, consequently, enhancing the engine–turbocharger matching calculation. The initial tuning of the model is based on turbine characteristic maps obtained with the by-pass port kept closed. The study then highlights the waste-gate valve behavior considering its different openings. It was found that a more refined model is necessary to accurately define the mass flow rate through the waste-gate valve. After independently tuning the 1D models of the turbine and the waste-gate valve, their behavior is analyzed in parallel-flow conditions. The results highlight significant interactions between the two components that must be taken into account to reduce inaccuracies in the engine-turbocharger matching calculation. These interactions lead to a reduced swallowing capacity of the turbine impeller. This reduction has an impact on the power delivered to the compressor, the boost pressure, and, consequently, the engine backpressure. The results suggest that methods generally adopted that consider the by-pass valve and the turbine as two nozzles working in parallel under the same thermodynamic condition could be insufficient to accurately assess the turbocharger behavior.
A Comparative Analysis of European Media Coverage of the Israel–Gaza War Using Hesitant Fuzzy Linguistic Term Sets
Authors: Abuasaker Walaa , Sánchez Mónica , Nguyen Jennifer , Agell Nil , Agell Núria , Ruiz Francisco J.
Published: January 2025

Representing and interpreting human opinions within an unstructured framework is inherently complex. Hesitant fuzzy linguistic term sets offer a comprehensive context that facilitates a nuanced understanding of diverse perspectives. This study introduces a methodology that integrates sentiment analysis with hesitant fuzzy linguistic term sets to effectively aggregate and compare news from diverse sources. By employing linguistic scales, our approach enhances the interpretation of various perceptions and attitudes, facilitating comprehensive knowledge extraction and representation. The main objective of this research is to conduct a comparative analysis of news coverage across European countries in relation to the Israel–Gaza war. This analysis aims to capture the multifaceted sensitivities surrounding the ongoing situation, highlighting how different nations perceive the conflict.
On the Graph Isomorphism Completeness of Directed and Multidirected Graphs
Authors: Pardo-Guerra Sebastian , George Vivek Kurien , Silva Gabriel A.
Published: January 2025

The category of directed graphs is isomorphic to a particular category whose objects are labeled undirected bipartite graphs and whose morphisms are undirected graph morphisms that respect the labeling. Based on this isomorphism, we begin by showing that the class of all directed graphs is a Graph Isomorphism Complete class. Afterwards, by extending this categorical framework to weighted prime graphs, we prove that the categories of multidirected graphs with and without self-loops are each isomorphic to a particular category of weighted prime graphs. Consequently, we prove that these classes of multidirected graphs are also Graph Isomorphism Complete.
Optimal Control of Heat Equation by Coupling FVM and FEM Codes
Authors: Baldini Samuele , Barbi Giacomo , Cervone Antonio , Giangolini Federico , Manservisi Sandro , Sirotti Lucia
Published: January 2025

In this paper, the optimal control theory is applied to a temperature optimization problem by coupling finite element and finite volume codes. The optimality system is split into the state and adjoint system. The direct problem is solved by the widely adopted finite volume OpenFOAM code and the adjoint-control equation using a variational formulation of the problem with the in-house finite element FEMuS code. The variational formulation of the problem is the natural framework for accurately capturing the control correction while OpenFOAM guarantees the accuracy of the state solution. This coupling is facilitated through the open-source MED and MEDCoupling libraries of the SALOME platform. The code coupling is implemented with the MED libraries and additional routines added in the FEMuS and OpenFOAM codes. We demonstrate the accuracy, robustness, and performance of the proposed approach with examples targeting different objectives using distributed and boundary controls in each case.
Implementation of ORBEYE®-Exoscope in the Operative Treatment of Spinal Dural Arteriovenous Fistula
Authors: Tonchev Nikolay , Neyazi Belal , Stein Klaus-Peter , Sandalcioglu I. Erol , Rashidi Ali
Published: January 2025

Spinal dural arteriovenous fistulas (sDAVFs) are rather uncommon lesions of the spine. In sDAVFs, which represent the most frequent form of vascular malformations of the spine, operative treatment remains the most common treatment modality. In operative surgery, visualization and pathology detection have a key impact on the results of the neurosurgical treatment of an sDAVF. The exoscope is one of the most recent imaging devices developed alongside the microscope and endoscope. The exoscope is being increasingly applied in neurosurgical procedures as an alternative to operative microscopes due to various advantages, such as its non-space-occupying camera, excellent visualization of the anatomical details and the perfect teaching possibilities it thus provides. In this publication, we present our experience in the treatment of a patient with an sDAVF, where surgery was performed exclusively with an ORBEYE-exoscope for the entire duration of the procedure. This report outlines the workflow and some of the technical pitfalls involved in managing this vascular pathology using the exoscopic technique.
Simulation and Experimental Study of the Single-Pulse Femtosecond Laser Ablation Morphology of GaN Films
Authors: Wang Mingyuan , Zhang Tong , Yuan Yanping , Wang Zhiyong , Liu Yanlei , Chen Lin
Published: January 2025

Gallium nitride (GaN) exhibits distinctive physical and chemical properties that render it indispensable in a multitude of electronic and optoelectronic devices. Given that GaN is a typical hard and brittle material that is difficult to machine, femtosecond laser technology provides an effective and convenient tool for processing such materials. However, GaN undergoes complex physical and chemical changes during high-power ablation, which poses a challenge to high-precision processing with controllable geometry. In this study, the quantitative relationship between the parameters of a single-pulse femtosecond laser and GaN ablation morphology was investigated using isotherm distribution. A multiphysics model using COMSOL Multiphysics® was developed to generate the isothermal distributions. Experiments were conducted on the femtosecond laser ablation of GaN at various single-pulse energies, and the resulting ablation morphologies were compared with the predictions from the multiphysics model. The comparison demonstrated that the calculated isotherm distribution accurately predicted not only the ablation diameter and depth but also the crater shape across a broad range of laser fluences. The predicted errors of the ablation diameters and depths were within 4.71% and 10.9%, respectively. The root mean square error (RMSE) and coefficient of determination (R2) were employed to evaluate the prediction errors associated with the crater shapes, which fell within the range of 0.018–0.032 μm and 0.77–0.91, respectively. This study can provide an important reference for utilizing femtosecond lasers in the precise ablation of GaN to achieve desired geometries.
Candida auris Antifungal Resistance, Virulence and Susceptibility to a Novel Nitric Oxide-Releasing Microparticle and Its Correlations to Clade Identification
Authors: Valdez Alessandro F. , Bohner Flora , Goldman Joshua P. , Jaquiery Ali B. , Amaral Eduardo V. C. do , Correa-Junior Dario , Draganski Andrew , Nimrichter Leonardo , Nosanchuk Joshua D. , Zamith-Miranda Daniel
Published: January 2025

Candida auris is a globally emerging pathogenic fungus described in Japan in 2009. This fungus has been identified mainly in nosocomial environments, associated with a high frequency of multidrug-resistant strains, and mortality rates reach 60%. C. auris is divided into 6 biogeographic clades, and there is a correlation between the clades and resistance against antifungals. In the current report, 8 strains of C. auris isolated in the Montefiore Medical Center, Bronx were analyzed to assess their clade (via ClaID) and common molecular determinants of antifungal resistance. We assessed antifungal resistance as well as the efficacy of a novel nitric oxide-donating microparticle as an alternative approach against C. auris in vitro through microplate susceptibility tests. Virulence was also determined in a Galleria mellonella model. Our results indicate that 7 out of 8 strains, belonging to clade 1, were resistant to fluconazole, while clade 2 was susceptible. Additionally, the clade 2 strain was more susceptible to treatment with the microparticle, while also being more virulent in an invertebrate model of infection. Our findings were then correlated to visualize parallels between clade identification and resistance/virulence patterns.
Epidemiological Analysis of a K. pneumoniae NDM Outbreak in a Temporary Ward for Patients with Primary COVID-19 Infection
Authors: Pruss Agata , Miładowska Klaudia , Masiuk Helena , Kwiatkowski Paweł , Jursa-Kulesza Joanna , Wojciuk Bartosz , Giedrys-Kalemba Stefania , Dołęgowska Barbara
Published: January 2025

The COVID-19 pandemic made the medical community realize how large a problem it would face. The epidemiological situation forced the opening of additional wards, the so-called “COVID wards”, where an increase in the rate of coexisting bacterial infections was observed. We report a hospital outbreak due to New Delhi carbapenemases producing K. pneumoniae clones. Twenty-eight K. pneumoniae strains were analyzed from patients with primary COVID-19 infection. The drug susceptibility of the strains was determined by the diffusion–circulation method and E-test. Phenotypic and PCR methods confirmed the production of carbapenemases. The phylogenetic similarity of the obtained strains was examined using pulsed-field electrophoresis. Most strains were isolated from bronchoalveolar lavage. All isolates obtained were resistant to β-lactams and fluoroquinolones. All strains produced New Delhi carbapenemases and were classified into two genetic clusters, A and B. Eight risk factors for secondary bacterial infection were analyzed. Following an intervention involving hand hygiene, strict contact prevention, and cleaning of the hospital environment and medical devices, this outbreak was successfully brought under control.
Evaluation of Risk Factors Influencing Tick-Borne Infections in Livestock Through Molecular Analyses
Authors: Cardillo Lorena , de Martinis Claudio , Sgroi Giovanni , Pucciarelli Alessia , Picazio Gerardo , Viscardi Maurizio , Marati Luisa , Ottaiano Maria , Pellicanò Roberta , D’Alessio Nicola , Veneziano Vincenzo , Fusco Giovanna
Published: January 2025

Climate changes and human-related activities are identified as major factors responsible for the increasing distribution and abundance of vectors worldwide and, consequently, of vector-borne diseases (VBDs). Farmed animals, during grazing or in establishments with the absence of biosecurity measures, can easily be exposed to wildlife showing high-risk of contagion of several infectious diseases, including VBDs. Furthermore, livestock represents an interface between wildlife and humans, and thus, promoting the transmission pathway of VBDs. Little is known about the presence and prevalence of VBDs in livestock in Southern Italy; therefore, the present study evaluated the circulation of zoonotic VBDs in livestock and potential risk of exposure. A total of 621 whole blood samples belonging to cattle and buffaloes (n = 345) and small ruminants (n = 276) were examined by molecular examinations for the detection of tick-borne pathogens (TBPs). High prevalence (66.3%) for at least one agent was observed. Moreover, the risk of exposure related to environmental features was assessed, as follows: presence of humid areas, high-density of animals, and sample collection during May. These results show a high circulation of TBPs among livestock and underline the need for surveillance in high-risk habitats for public health.
Plasma Optimization as a Novel Tool to Explore Plant–Microbe Interactions in Climate Smart Agriculture
Authors: Mohan Binoop , Karthik Chandrima , Thingujam Doni , Pajerowska-Mukhtar Karolina M. , Thomas Vinoy , Mukhtar M Shahid
Published: January 2025

Plasma treatment has emerged as a promising tool for manipulating plant microbiomes and metabolites. This review explores the diverse applications and effects of plasma on these biological systems. It is hypothesized that plasma treatment will not induce substantial changes in the composition of plant microbiomes or the concentration of plant metabolites. We delve into the mechanisms by which plasma can regulate microbial communities, enhance antimicrobial activity, and recruit beneficial microbes to mitigate stress. Furthermore, we discuss the optimization of plasma parameters for effective microbiome interaction and the role of plasmids in plant–microbe interactions. By characterizing plasmidome responses to plasma exposure and investigating transcriptional and metabolomic shifts, we provide insights into the potential of plasma as a tool for engineering beneficial plant–microbe interactions. The review presented herein demonstrates that plasma treatment induces substantial changes in both microbial community composition and metabolite levels, thereby refuting our initial hypothesis. Finally, we integrate plasmidome, transcriptome, and metabolome data to develop a comprehensive understanding of plasma’s effects on plant biology and explore future perspectives for agricultural applications.