bluuebunny/crossref_metadata_2025 huggingface dataset:
Predicting the long-term performance of a wide embankment on soft soil using an elastic–viscoplastic model
Authors: Karim M. R. , Gnanendran C. T. , Lo S.-C. R. , Mak J.
Published: February 2010

This paper presents modelling of the consolidation of foundation soil under a wide embankment constructed over soft soil. An elastic–viscoplastic (EVP) constitutive model is used to represent the foundation soil for the coupled finite element analysis (FEA). A unit-cell analysis is carried out to capture the maximum settlement and the development of excess pore-water pressure with time below the centreline of the embankment for a long period (9 years). A new function for capturing the varying nature of the creep or secondary compression coefficient is proposed and used in association with the EVP model. The input material parameters for this study were determined from extensive laboratory experiments except for the equivalent horizontal permeability, which was systematically estimated by using vertical permeability data obtained from one-dimensional consolidation tests and by back-analysing the first 12 months of field settlement data. Comparisons are made among the predictions obtained adopting an elastoplastic modified Cam clay model and the EVP model with constant and varying creep coefficients for the foundation soil and the corresponding field data. The predictions with the EVP model are found to be better than those with the elastoplastic model and the use of a varying creep coefficient for the EVP model seems to further improve its predicting ability.
Intelligent computing for modeling axial capacity of pile foundations
Authors: Shahin Mohamed A.
Published: February 2010

In the last few decades, numerous methods have been developed for predicting the axial capacity of pile foundations. Among the available methods, the cone penetration test (CPT)-based models have been shown to give better predictions in many situations. This can be attributed to the fact that CPT-based methods have been developed in accordance with the CPT results, which have been found to yield more reliable soil properties; hence, more accurate axial pile capacity predictions. In this paper, one of the most commonly used artificial intelligence techniques, i.e., artificial neural networks (ANNs), is utilized in an attempt to develop artificial neural network (ANN) models that provide more accurate axial capacity predictions for driven piles and drilled shafts. The ANN models are developed using data collected from the literature and comprise 80 driven pile and 94 drilled-shaft load tests, as well as CPT results. The predictions from the ANN models are compared with those obtained from the most commonly used available CPT-based methods, and statistical analyses are carried out to rank and evaluate the performance of the ANN models and CPT methods. To facilitate the use of the developed ANN models, they are translated into simple design equations suitable for hand calculations.
NEW DEVELOPMENTS IN RELATIVISTIC VISCOUS HYDRODYNAMICS
Authors: ROMATSCHKE PAUL
Published: February 2010

Starting with a brief introduction into the basics of relativistic fluid dynamics, I discuss our current knowledge of a relativistic theory of fluid dynamics in the presence of (mostly shear) viscosity. Derivations based on the generalized second law of thermodynamics, kinetic theory, and a complete second-order gradient expansion are reviewed. The resulting fluid dynamic equations are shown to be consistent for all these derivations, when properly accounting for the respective region of applicability, and can be applied to both weakly and strongly coupled systems. In its modern formulation, relativistic viscous hydrodynamics can directly be solved numerically. This has been useful for the problem of ultrarelativistic heavy-ion collisions, and I will review the setup and results of a hydrodynamic description of experimental data for this case.
AVOID THE TSUNAMI OF THE DIRAC SEA IN THE IMAGINARY TIME STEP METHOD
Authors: ZHANG YING , LIANG HAOZHAO , MENG JIE
Published: February 2010

The discrete single-particle spectra in both the Fermi and Dirac sea have been calculated by the imaginary time step (ITS) method for the Schrödinger-like equation after avoiding the "tsunami" of the Dirac sea, i.e. the diving behavior of the single-particle level into the Dirac sea in the direct application of the ITS method for the Dirac equation. It is found that by the transform from the Dirac equation to the Schrödinger-like equation, the single-particle spectra, which extend from the positive to the negative infinity, can be separately obtained by the ITS evolution in either the Fermi sea or the Dirac sea. Identical results with those in the conventional shooting method have been obtained via the ITS evolution for the equivalent Schrödinger-like equation, which demonstrates the feasibility, practicality and reliability of the present algorithm and dispels the doubts on the ITS method in the relativistic system.
NONCOMMUTATIVE SPACETIME, MASS GENERATION, AND OTHER EFFECTS
Authors: SIDHARTH B. G.
Published: February 2010

In this paper, we show how it is possible to obtain mass generation in the context of non-Abelian gauge field theory, using a noncommutative spacetime. This is further confirmed by the modified dispersion relation that results from such a geometry. Other effects in the domain of ultra high energy gamma rays and cosmic rays are also deduced and it is pointed out that we might already have observed such effects.
CHARMED BARYON IN A STRING MODEL
Authors: QING-WU WANG , PENG-MING ZHANG
Published: February 2010

Charmed baryon spectroscopy has been studied under a string model. In this model, charmed baryons are composed of a diquark and a charm quark which are connected by a constant tension. In this diquark picture, the quantum numbers JP of confirmed baryons have been well assigned. Energies of the first and second orbital excitations have been predicted and compared with the experimental data. Meanwhile, diquark masses have been extracted in the background of charm quark which satisfy a splitting relation based on spin–spin interaction.
CALCULATION OF FUSION CROSS-SECTION FOR 3He+6Li SYSTEM AT NEAR BARRIER ENERGIES
Authors: MAHDAVI M. , KOOHROKHI T. , KALEJI B. , JALALEE B.
Published: February 2010

A correct formula for fusion cross-section is proposed for better understanding of light nuclear fusion plasma. It is based on the one-dimensional method. The fusion cross-section and the Maxwellian rate parameters of the 3 He +6 Li system are calculated. The obtained results are in good accord with theoretical data of other researchers.
A CRYSTAL PLASTICITY STUDY OF THE NECKING OF MICRO-FILMS UNDER TENSION
Authors: WANG S. , ZHUANG W. , BALINT D. S. , LIN J.
Published: February 2010

An integrated crystal viscoplastic modeling process has been developed to account for the effect of microstructure in the mechanical response of polycrystalline materials. Grain distributions, including size, shape and orientation, are generated automatically based on probability theories using VGRAIN software. For each set of control parameters (average, maximum and minimum grain size) used in the micro-film simulations, six grain orientation patterns were generated randomly for a micro-film based on a gamma distribution; a large number of analyses have been carried out to account for statistical variations in the spatial pattern of grain orientations. The simulations are used to investigate the effects of grain size and orientation on necking and flow stress in stainless steel under uniaxial tension, and to quantify the extent that variability in the spatial distribution of orientations affects the predictions. Based on the numerical studies, a map was generated indicating under what circumstances macro-mechanics theory can be used and when Crystal Plasticity (CP) theory must be used to ensure the accuracy of the analysis; if the theories are not used appropriately, huge errors can be expected.
The Physiological Significance of the Cardiotonic Steroid/Ouabain-Binding Site of the Na,K-ATPase
Authors: Lingrel Jerry B
Published: February 2010

The Na,K-ATPase is the membrane “pump” that generates the Na+and K+gradients across the plasma membrane that drives many physiological processes. This enzyme is highly sensitive to inhibition by cardiotonic steroids, most notably the digitalis/ouabain class of compounds, which have been used for centuries to treat congestive heart failure and arrhythmias. The amino acids that constitute the ouabain-binding site are highly conserved across the evolutionary spectrum. This could be fortuitous or could result from this site being conserved because it has an important biological function. New physiological approaches using genetically engineered mice are being used to define the biological significance of the “receptor function” of the Na,K-ATPase and its regulation by potential endogenous cardiotonic steroid-like compounds. These studies extend the reach of earlier studies involving the biochemical purification of endogenous regulatory ligands.
Regulation of Endothelial Permeability via Paracellular and Transcellular Transport Pathways
Authors: Komarova Yulia , Malik Asrar B.
Published: February 2010

The endothelium functions as a semipermeable barrier regulating tissue fluid homeostasis and transmigration of leukocytes and providing essential nutrients across the vessel wall. Transport of plasma proteins and solutes across the endothelium involves two different routes: one transcellular, via caveolae-mediated vesicular transport, and the other paracellular, through interendothelial junctions. The permeability of the endothelial barrier is an exquisitely regulated process in the resting state and in response to extracellular stimuli and mediators. The focus of this review is to provide a comprehensive overview of molecular and signaling mechanisms regulating endothelial barrier permeability with emphasis on the cross-talk between paracellular and transcellular transport pathways.
Mammalian Per-Arnt-Sim Proteins in Environmental Adaptation
Authors: McIntosh Brian E. , Hogenesch John B. , Bradfield Christopher A.
Published: February 2010

The Per-Arnt-Sim (PAS) domain is conserved across the kingdoms of life and found in an ever-growing list of proteins. This domain can bind to and sense endogenous or xenobiotic small molecules such as molecular oxygen, cellular metabolites, or polyaromatic hydrocarbons. Members of this family are often found in pathways that regulate responses to environmental change; in mammals these include the hypoxia, circadian, and dioxin response pathways. These pathways function in development and throughout life to regulate cellular, organ, and whole-organism adaptive responses. Remarkably, in the case of the clock, this adaptation includes anticipation of environmental change. In this review, we summarize the roles of PAS domain–containing proteins in mammals. We provide structural evidence that functionally classifies both known and unknown biological roles. Finally, we discuss the role of PAS proteins in anticipation of and adaptation to environmental change.
Cell Death in the Pathogenesis of Heart Disease: Mechanisms and Significance
Authors: Whelan Russell S. , Kaplinskiy Vladimir , Kitsis Richard N.
Published: February 2010

Cell death was once viewed as unregulated. It is now clear that at least a portion of cell death is a regulated cell suicide process. This type of death can exhibit multiple morphologies. One of these, apoptosis, has long been recognized to be actively mediated, and many of its underlying mechanisms have been elucidated. Moreover, necrosis, the traditional example of unregulated cell death, is also regulated in some instances. Autophagy is usually a survival mechanism but can occur in association with cell death. Little is known, however, about how autophagic cells die. Apoptosis, necrosis, and autophagy occur in cardiac myocytes during myocardial infarction, ischemia/reperfusion, and heart failure. Pharmacological and genetic inhibition of apoptosis and necrosis lessens infarct size and improves cardiac function in these disorders. The roles of autophagy in ischemia/reperfusion and heart failure are unresolved. A better understanding of these processes and their interrelationships may allow for the development of novel therapies for the major heart syndromes.
Neuronal expression of sodium/bicarbonate cotransporter NBCn1 (SLC4A7) and its response to chronic metabolic acidosis
Authors: Park Hae Jeong , Rajbhandari Ira , Yang Han Soo , Lee Soojung , Cucoranu Delia , Cooper Deborah S. , Klein Janet D. , Sands Jeff M. , Choi Inyeong
Published: February 2010

The sodium-bicarbonate cotransporter NBCn1 (SLC4A7) is an acid-base transporter that normally moves Na+and HCO3−into the cell. This membrane protein is sensitive to cellular and systemic pH changes. We examined NBCn1 expression and localization in the brain and its response to chronic metabolic acidosis. Two new NBCn1 antibodies were generated by immunizing a rabbit and a guinea pig. The antibodies stained neurons in a variety of rat brain regions, including hippocampal pyramidal neurons, dentate gyrus granular neurons, posterior cortical neurons, and cerebellar Purkinje neurons. Choroid plexus epithelia were also stained. Double immunofluorescence labeling showed that NBCn1 and the postsynaptic density protein PSD-95 were found in the same hippocampal CA3 neurons and partially colocalized in dendrites. PSD-95 was pulled down from rat brain lysates with the GST/NBCn1 fusion protein and was also coimmunoprecipitated with NBCn1. Chronic metabolic acidosis was induced by feeding rats with normal chow or 0.4 M HCl-containing chow for 7 days. Real-time PCR and immunoblot showed upregulation of NBCn1 mRNA and protein in the hippocampus of acidotic rats. NBCn1 immunostaining was enhanced in CA3 neurons, posterior cortical neurons, and cerebellar granular cells. Intraperitoneal administration of N-methyl-d-aspartate caused neuronal death determined by caspase-3 activity, and this effect was more severe in acidotic rats. Administering N-methyl-d-aspartate also inhibited NBCn1 upregulation in acidotic rats. We conclude that NBCn1 in neurons is upregulated by chronic acid loads, and this upregulation is associated with glutamate excitotoxicity.
Coupling-induced complexity in nephron models of renal blood flow regulation
Authors: Laugesen Jakob L. , Sosnovtseva Olga V. , Mosekilde Erik , Holstein-Rathlou Niels-Henrik , Marsh Donald J.
Published: February 2010

Tubular pressure and nephron blood flow time series display two interacting oscillations in rats with normal blood pressure. Tubuloglomerular feedback (TGF) senses NaCl concentration in tubular fluid at the macula densa, adjusts vascular resistance of the nephron's afferent arteriole, and generates the slower, larger-amplitude oscillations (0.02–0.04 Hz). The faster smaller oscillations (0.1–0.2 Hz) result from spontaneous contractions of vascular smooth muscle triggered by cyclic variations in membrane electrical potential. The two mechanisms interact in each nephron and combine to act as a high-pass filter, adjusting diameter of the afferent arteriole to limit changes of glomerular pressure caused by fluctuations of blood pressure. The oscillations become irregular in animals with chronic high blood pressure. TGF feedback gain is increased in hypertensive rats, leading to a stronger interaction between the two mechanisms. With a mathematical model that simulates tubular and arteriolar dynamics, we tested whether an increase in the interaction between TGF and the myogenic mechanism can cause the transition from periodic to irregular dynamics. A one-dimensional bifurcation analysis, using the coefficient that couples TGF and the myogenic mechanism as a bifurcation parameter, shows some regions with chaotic dynamics. With two nephrons coupled electrotonically, the chaotic regions become larger. The results support the hypothesis that increased oscillator interactions contribute to the transition to irregular fluctuations, especially when neighboring nephrons are coupled, which is the case in vivo.
Effect of catecholamines on rat medullary thick ascending limb chloride transport: interaction with angiotensin II
Authors: Baum Michel
Published: February 2010

Previous studies have shown that in proximal and distal tubule nephron segments, peritubular ANG II stimulates sodium chloride transport. However, ANG II inhibits chloride transport in the medullary thick ascending limb (mTAL). Because ANG II and catecholamines are both stimulated by a decrease in extracellular fluid volume, the purpose of this study was to examine whether there was an interaction between ANG II and catecholamines to mitigate the inhibition in chloride transport by ANG II. In isolated perfused rat mTAL, 10−8M bath ANG II inhibited transport (from a basal transport rate of 165.6 ± 58.8 to 58.8 ± 29.4 pmol·mm−1·min−1; P < 0.01). Bath norepinephrine stimulated chloride transport (from a basal transport rate of 298.1 ± 31.7 to 425.2 ± 45.8 pmol·mm−1·min−1; P < 0.05) and completely prevented the inhibition in chloride transport by ANG II. The stimulation of chloride transport by norepinephrine was mediated entirely by its β-adrenergic effect; however, both the β- and α-adrenergic agonists isoproterenol and phenylephrine prevent the ANG II-mediated inhibition in chloride transport. In the presence of 10−5M propranolol, the effect of norepinephrine to prevent the inhibition of chloride transport by ANG II was still present. These data are consistent with an interaction of both α- and β-catecholamines and ANG II on net chloride transport in the mTAL.
The impact of the endothelin type A receptor on regional endothelin-1 turnover, in particular renal endothelin-1 release, in humans
Authors: Rullman Eric , Gustafsson Thomas , Ahlborg Gunvor
Published: February 2010

The endothelin type A (ETA) receptor was studied in six healthy subjects on two occasions with or without an ETA receptor (BQ-123) blockade. At 40 min of either BQ-123 or NaCl infusion, a concomitant infusion of the endothelin-1 (ET-1) precursor, big ET-1, was initiated to augment ET-1 formation. Blood samples were taken from catheters in a peripheral artery, the renal and femoral veins, and the pulmonary artery. Forty minutes of infusion with BQ-123 alone increased heart rate ( P < 0.001) and cardiac output (CO; P < 0.01) and depressed mean arterial blood pressure ( P < 0.001) and systemic vascular resistance (SVR; P < 0.01). During infusion of big ET-1 alone, CO, stroke volume, and renal blood flow decreased ( P < 0.01), whereas SVR and pulmonary and renal vascular resistance increased ( P < 0.05). These responses to big ET-1 were abolished or diminished by BQ-123. Renal ET-1 release was threefold higher when big ET-1 infusion was preceded by BQ-123 infusion ( P < 0.001). Arterial ET-1 concentrations rose to similar levels after big ET-1 infusion ( P < 0.01) in both trials because of elevated concomitant pulmonary uptake ( P < 0.05) after ETA blockade. Although there was no net ET-1 leg exchange, leg ET-1 turnover was higher after big ET-1 was preceded by BQ-123. Gene expression of endothelin-converting enzyme 1 and ET-1 in skeletal muscle remained unaltered on both occasions. Our data demonstrate that the level of circulating ET-1 is regulated by ETA receptor-mediated negative feedback. This mechanism seems to be coupled to increased conversion of big ET-1 and is most potent in the kidneys. This emphasizes the important physiological role of ETA receptors in the kidneys, and the lung seems to be mainly a clearing organ for ET-1.
Major Differences in the Proportion of Amino Acid Fiber Types Transmitting Taste Information From Oral and Extraoral Regions in the Channel Catfish
Authors: Ogawa Kazuaki , Caprio John
Published: February 2010

The present study investigates for the first time in any teleost the amino acid specificity and sensitivity of single glossopharyngeal (cranial nerve IX) fibers that innervate taste buds within the oropharyngeal cavity. These results are contrasted with similar data obtained from facial (cranial nerve VII) fibers that innervate extraoral taste buds. The major finding is that functional differences are clearly evident between taste fibers of these two cranial nerves. Catfishes possess the most extensive distribution of taste buds found in vertebrates. Taste buds on the external body surface are exclusively innervated by VII, whereas IX, along with the vagus (X), innervate the vast majority of taste buds within the oropharyngeal cavity. Responses to the l-isomers of alanine (Ala), arginine (Arg), and proline (Pro), the three most stimulatory amino acids that bind to independent taste receptors, were obtained from 90 single VII and 64 single IX taste fibers. This study confirmed a previous investigation that the amino acid responsive VII fibers consist of two major groups, the Ala and Arg clusters containing taste fibers having thresholds in the ηM range. In contrast, the present study indicates the amino acid responsive IX taste system is dominated by taste fibers responsive to Pro and to Pro and Arg, respectively, has a reduced percentage of Ala fibers, and is less sensitive than VII. The present electrophysiological results are consistent with previous experiments, indicating that the extraoral taste system is essential for appetitive behavior, whereas oropharyngeal taste buds are critical for consummatory behavior.
Ileocecal Intussusception with Histomorphological Features of Inflammatory Neuropathy in Adenovirus Infection
Authors: Kaemmerer Elke , Tischendorf Jens J. W. , Steinau Gerd , Wagner Norbert , Gassler Nikolaus
Published: February 2010

The pathophysiological mechanisms for ileocecal intussusception in children with adenovirus infection are not well characterized. Here we demonstrate coincidence of adenovirus infection and inflammatory neuropathy of myenteric plexus in two children with ileocecal intussusception. Inflammatory neuropathy, an unspecific morphological feature which is found in peristalsis disorders, was morphologically characterized by the influx of CD3 positive lymphocytes in nervous plexus. To our knowledge, this is the first report suggesting peristalsis disorders from inflammatory neuropathy as additional mechanism in the pathophysiological concept of adenovirus-associated ileocecal intussusception.
Tumour Cell Lines HT-29 and FaDu Produce Proinflammatory Cytokines and Activate Neutrophils In Vitro: Possible Applications for Neutrophil-Based Antitumour Treatment
Authors: Brú Antonio , Souto Juan-Carlos , Alcolea Sonia , Antón Rosa , Remacha Angel , Camacho Mercedes , Soler Marta , Brú Isabel , Porres Amelia , Vila Luis
Published: February 2010

There is evidence that polymorphonuclear neutrophils (PMNs) can exert severe antineoplastic effects. Cross-talk between tumour cells and endothelial cells (ECs) is necessary for the accumulation of PMN around a tumour. This work reports the ability of two PMN-sensitive, human, permanent cell lines—colorectal adenocarcinoma (HT-29) and pharyngeal squamous-cell carcinoma (FaDu) cells—to act as inflammatory foci. PMNs were cytotoxic to both lines, the adhesion of the PMNs to the tumour cells being important in this effect. The tumour cells released appreciable amounts of IL-8 and GROα, and induced the transmigration of PMN through human microvascular-EC monolayers. Conditioning media associated with both lines induced the adhesion of PMN and the surface expression of ICAM-1 in microvascular-EC. In addition, FaDu-conditioning-medium strongly induced the production of proinflammatory cytokines by microvascular-EC. These results support the idea that tumour cells might normally induce a potent acute inflammatory response, leading to their own destruction.
The Szlenk Index and the Fixed Point Property under Renorming
Authors: Benavides TDomínguez
Published: February 2010

Assume that "Equation missing" is a Banach space such that its Szlenk index "Equation missing" is less than or equal to the first infinite ordinal "Equation missing". We prove that "Equation missing" can be renormed in such a way that "Equation missing" with the resultant norm satisfies "Equation missing", where "Equation missing" is the García-Falset coefficient. This leads us to prove that if "Equation missing" is a Banach space which can be continuously embedded in a Banach space "Equation missing" with "Equation missing", then, "Equation missing" can be renormed to satisfy the w-FPP. This result can be applied to Banach spaces which can be embedded in "Equation missing", where "Equation missing" is a scattered compact topological space such that "Equation missing". Furthermore, for a Banach space "Equation missing", we consider a distance in the space "Equation missing" of all norms in "Equation missing" which are equivalent to "Equation missing" (for which "Equation missing" becomes a Baire space). If "Equation missing", we show that for almost all norms (in the sense of porosity) in "Equation missing", "Equation missing" satisfies the w-FPP. For general reflexive spaces (independently of the Szlenk index), we prove another strong generic result in the sense of Baire category.
Online Detection of P300 and Error Potentials in a BCI Speller
Authors: Dal Seno Bernardo , Matteucci Matteo , Mainardi Luca
Published: February 2010

Error potentials (ErrPs), that is, alterations of the EEG traces related to the subject perception of erroneous responses, have been suggested to be an elegant way to recognize misinterpreted commands in brain-computer interface (BCI) systems. We implemented a P300-based BCI speller that uses a genetic algorithm (GA) to detect P300s, and added an automatic error-correction system (ECS) based on the single-sweep detection of ErrPs. The developed system was tested on-line on three subjects and here we report preliminary results. In two out of three subjects, the GA provided a good performance in detecting P300 (90% and 60% accuracy with 5 repetitions), and it was possible to detect ErrP with an accuracy (roughly 60%) well above the chance level. In our knowledge, this is the first time that ErrP detection is performed on-line in a P300-based BCI. Preliminary results are encouraging, but further refinements are needed to improve performances.
Iterative Algorithms with Variable Coefficients for Asymptotically Strict Pseudocontractions
Authors: Ge Ci-Shui , Liang Jin , Xiao Ti-Jun
Published: February 2010

We introduce and study some new CQ-type iterative algorithms with variable coefficients for asymptotically strict pseudocontractions in real Hilbert spaces. General results for asymptotically strict pseudocontractions are established. The main result extends the previous results.
Transitory Blocking of Pulmonary Artery and Veins as a Novel Strategy in Pulmonary Surgery: An Experimental Study in a Rabbit Model
Authors: Jiang F. , Yin R. , Wang Z. , Chen J. , Yang M. , Xu L.
Published: February 2010

Backgrounds: Transitory blocking of the pulmonary artery and veins is now being applied in the treatment of local advanced non-small cell lung cancer in our department. We performed this study to establish a pulmonary vessel blocking model in rabbits and investigate the features of lung ischemia-reperfusion injury. Methods: 126New Zealand rabbits were randomized into 3 groups: group I, sham group; group II, left pulmonary artery blocking, and group III, left pulmonary artery and veins blocking. The physiological data as well as the blood and tissue samples were harvested at the time of thoracotomy, at 1 h after ischemia and 1, 2, 4, 6 and 24 h after reperfusion, respectively. Lung injury was assessed histologically by determining the levels of malondialdehyde, superoxide dismutase, myeloperoxidase and water content. Results: The hemodynamics were stable in all three groups. The levels of malondialdehyde, myeloperoxidase, and water content of lung tissue were all significantly increased in groups II and III when compared with group I at 1, 2, 4 and 6 h after reperfusion. They almost all returned to baseline at 24 h after reperfusion. However, there was no significant difference observed between groups II and III at either time point. A similar change in the process of lung ischemia-reperfusion injury was observed under light and electron microscopes in group II and in group III. Conclusions: The features of lung ischemia-reperfusion injury were similar when blocking the pulmonary artery and veins compared with blocking the pulmonary artery alone. Moreover, it might be safe to block the pulmonary vessels within 1 h during pulmonary surgery.
Comparison of Hearing Improvement and Complications after Stapes Surgery with and without Potassium Titanyl Phosphate Laser for Manipulation of the Foot Plate
Authors: Sakamoto Takashi , Iwamura Hitoshi , Kashio Akinori , Ito Ken , Kaga Kimitaka , Suzuki Mitsuya , Yamasoba Tatsuya
Published: February 2010

Objective: The purpose of the current study was to evaluate the differences in hearing results and complications between the conventional technique (CT) and potassium titanyl phosphate laser (KTP) laser-assisted stapes surgery that does not involve the manipulation of the foot plate. Methods: Ninety-eight ears with conductive or mixed hearing loss due to otosclerosis were operated on by using the CT or KTP laser-assisted manipulation. The results of pure-tone audiometry, the duration of postoperative vestibular symptoms, and the presence of damage to the foot plate were reviewed retrospectively. Results: The extent of hearing improvement and the duration of vestibular symptoms were not significantly different between the two groups. The damage to the foot plate was significantly less frequent in the KTP group compared to the CT group. Profound sensorineural hearing loss occurred in one case in the CT group, whereas no significant sensorineural hearing loss was detected in the KTP group. Conclusions: According to our present findings, KTP laser-assisted surgery was safer than CT in terms of the damage to the foot plate even when the KTP laser was not used for opening the foot plate. However, both techniques showed similar results in hearing improvement and vestibular symptoms.
Multifocal Motor Neuropathy: Update on Clinical Characteristics, Pathophysiological Concepts and Therapeutic Options
Authors: Meuth Sven G. , Kleinschnitz Christoph
Published: February 2010

Multifocal motor neuropathy (MMN) is an acquired immune-mediated neuropathy characterized by chronic or stepwise progressive asymmetrical limb weakness without sensory deficits. The upper extremities are more often affected than the lower extremities with distal paresis dominating over proximal paresis. Important diagnostic features are persistent multifocal partial conduction blocks (CBs) and the presence of high-titer anti-GM1 serum antibodies. Motor neuron disease, other chronic dysimmune neuropathies, such as chronic inflammatory demyelinating polyneuropathy and the Lewis-Sumner syndrome (MADSAM neuropathy), are important differential diagnoses. While corticosteroids and plasma exchange are largely ineffective, high-dose intravenous immunoglobulins are regarded as first-line treatment. In spite of significant success in elucidating the underlying disease mechanisms in MMN during the past few years, important pathophysiological issues and the optimum long-term therapy remain to be clarified. The present review summarizes the clinical picture and current pathophysiological concepts of MMN with a special focus on the molecular and electrophysiological basis of CBs and highlights established therapies as well as possible novel treatment options.
Transcranial Magnetic Stimulation for Drug-Resistant Epilepsies: Rationale and Clinical Experience
Authors: Kimiskidis Vasilios K.
Published: February 2010

Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation technique which, over the last 25 years, has greatly expanded from a simple method for stimulating the motor cortex to an invaluable tool with multiple research, diagnostic and even therapeutic applications. In this review, we discuss the use of repetitive TMS as a means of suppressing cortical hyperexcitability in drug-resistant epilepsies. The theoretical background and the experimental evidence in favor of this novel therapeutic approach are presented, and a number of open-label and controlled studies in patients with various forms of focal epilepsy are reviewed. It is concluded that, although the therapeutic effects of repetitive TMS in epilepsy appear rather limited, further clinical testing of this rapidly evolving technology is warranted.
Sensitization to Inhaled Ryegrass Pollen by Collateral Priming in a Murine Model of Allergic Respiratory Disease
Authors: Cadot Pascal , Meyts Isabelle , Vanoirbeek Jeroen A.J. , Vanaudenaerde Bart , Bullens Dominique M.A. , Ceuppens Jan L.
Published: February 2010

Background: Mouse models of asthma suffer from the necessity to prime the animals by injections before respiratory exposure. Our aim was to develop a mouse model that mimics the progression of human allergic disease upon low-dose inhaled allergen exposure. Methods: Mice were primed intraperitoneally to ovalbumin (OVA) before they were exposed repeatedly to aerosols of either OVA, ryegrass (Lolium perenne) pollen extract, or both concomitantly. The sensitization to ryegrass pollen proteins was evaluated by measurement of specific serum antibody, by the respiratory response to a challenge with ryegrass pollen extract and by lung cytokine production after challenge. Results: Inhalation of ryegrass pollen extract alone did not result in sensitization. Sensitization to inhaled ryegrass pollen proteins, however, did occur in mice that had been sensitized to OVA by intraperitoneal injections and were then exposed to inhaled ryegrass pollen extract and OVA simultaneously. T and B cell priming was ascertained by ryegrass pollen-specific IgG1 and IgE antibody production and by induction of airway inflammation and of Th2 cytokine mRNA transcripts in the lungs upon airway challenge with ryegrass pollen extract. A progressive spread of the IgE/IgG1 response to different ryegrass pollen proteins could be visualized in immunoblots by comparing antibody patterns at day 56 and 86. Conclusions: Low-dose inhalatory allergen exposure results in sensitization when airways are exposed at the same time to another allergen to which the animals are already sensitized. This model can help to unravel the mechanisms that underlie the development and progression of respiratory allergic diseases.
Neutrophil Apoptosis: Relevance to the Innate Immune Response and Inflammatory Disease
Authors: Fox Sarah , Leitch Andrew E. , Duffin Rodger , Haslett Christopher , Rossi Adriano G.
Published: February 2010

Neutrophils are the most abundant cell type involved in the innate immune response. They are rapidly recruited to sites of injury or infection where they engulf and kill invading microorganisms. Neutrophil apoptosis, the process of programmed cell death that prevents the release of neutrophil histotoxic contents, is tightly regulated and limits the destructive capacity of neutrophil products to surrounding tissue. The subsequent recognition and phagocytosis of apoptotic cells by phagocytic cells such as macrophages is central to the successful resolution of an inflammatory response and it is increasingly apparent that the dying neutrophil itself exerts an anti-inflammatory effect through modulation of surrounding cell responses, particularly macrophage inflammatory cytokine release. Apoptosis may be delayed, induced or enhanced by micro-organisms dependent on their immune evasion strategies and the health of the host they encounter. There is now an established field of research aimed at understanding the regulation of apoptosis and its potential as a target for therapeutic intervention in inflammatory and infective diseases. This review focuses on the physiological regulation of neutrophil apoptosis with respect to the innate immune system and highlights recent advances in mechanistic understanding of apoptotic pathways and their therapeutic manipulation in appropriate and excessive innate immune responses.
The Rise and Fall of the Merchant Guilds: Re-thinking the Comparative Study of Commercial Institutions in Premodern Europe
Authors: Gelderblom Oscar , Grafe Regina
Published: February 2010

Although the importance of merchant guilds for the commercial development of Europe is beyond doubt, scholars do not agree about why they emerged, persisted, and ultimately declined between the eleventh and eighteenth centuries. Historical studies usually focus on individual cases and idiosyncratic circumstances that restrict comparisons, whereas economic approaches based on game or contract theory often impose narrow assumptions on their models that tend to neglect two key features of these institutions: In imperfect markets, merchants used more than one institution to solve a given problem, and individual institutions often addressed more than one problem. However, a new methodological approach (maximum likelihood estimation) permits rigorous comparative analysis of the probability that merchants, under a given set of market and political circumstances, will delegate control of their dealings. This model requires only one assumption—that merchants relinquished such control only when they expected a positive return.
“Working the Waves”: The Plebeian Culture and Moral Economy of Traditional Basque Fishing Brotherhoods
Authors: Hess Andreas
Published: February 2010

Although by the twentieth century, industrial-capitalist fishing methods were already disrupting the Basque fishing brotherhoods (cofradías), the collective voice of the fishermen and their communities, artisanal fishing, and the traditional customs surrounding it managed to survive for a few more decades. At the beginning of the twenty-first century, however, the future for local Basque fishermen looks bleak. Due to factors beyond their control, the brotherhoods, which for a long time guaranteed both an ecological balance in the sea and common wealth among the fishermen, have become totally defunct.
Haptic Glove with MR Brakes for Distributed Finger Force Feedback
Authors: Bullion Conrad , Gurocak Hakan
Published: February 2010

Most existing haptic gloves are complicated user interfaces with remotely located actuators. More compact and simpler haptic gloves would greatly increase our ability to interact with virtual worlds in a more natural way. This research explored the design of a compact force feedback glove using a new finger mechanism and magnetorheological (MR) brakes as passive actuators that oppose human finger motion. The mechanism allowed for a reduction of the number of actuators and application of distributed forces at the bottom surface of user's fingers when an object was grasped in a virtual environment. The MR brakes incorporated a serpentine flux path that led to a small brake with high torque output and the elimination of remote actuation. Force analysis of the mechanism, grasping force experiments, and virtual pick-and-place experiments were done. The glove reduced task completion time by 61% and could support up to 17 N fingertip force along with 11.9 N and 18.7 N middle and proximal digit forces.
The Paradox of Victim-Centrism: Victim Participation at the Khmer Rouge Tribunal
Authors: Mohan Mahdev
Published: February 2010

It has been claimed – though not proved – that victims will be benefited by participation in international criminal tribunals. This article interrogates this claim in the context of victim participation at the Extraordinary Chambers in the Courts of Cambodia (ECCC), commonly referred to as the Khmer Rouge Tribunal. Based on interviews with Cambodian victims and Tribunal affiliates, it examines why and how the Tribunal permits victims to intervene as les parties civile, pulling together the normative and legal basis for this mode of victim participation. This article does not purport to generalize with confidence about Cambodian victims in general, let alone all victims of mass atrocity. Instead, it simply seeks to move beyond vague speculations that victim participation in international trials is always therapeutic, and suggest a new indigenized victimology that the Tribunal should explore as the long-awaited trials of the Khmer Rouge unfold.
The Swan Song of Universal Jurisdiction in Spain
Authors: de la Rasilla del Moral Ignacio
Published: February 2010

On 29 April 2009 the Spanish National Court opened a cause against the "perpetrators, the instigators, the necessary collaborators and accomplices" of alleged tortures at the Guantanamo camp and other overseas detention facilities. Before examining how these and other causes currently opened in Spain under the principle of universal jurisdiction enshrined by Art. 23.4 of the Organic Law of the Judicial Branch (LOPJ) are likely to be affected by the legislative reform of that very provision approved by the Spanish Congress of Deputies on 25 June 2009, we will first examine the sinuous - and now dramatically indicative in retrospect - jurisprudential evolution of the treatment of the principle of universal justice by Spanish Courts since the Constitutional Court enshrined a doctrine of unconditional universal jurisdiction in its widely celebrated Guatemala Genocide case in June 2005. This is complemented by an overview of the cases that, jurisdictionally based on the principle of universal justice enshrined by Article 23 of the LOPJ, are still currently open (from e.g., Tibet to Rwanda or Gaza) before Spanish Courts. In addition, set against the background provided by the release of the four so-called "torture memos" by the Obama Administration in April 2009, there is a brief examination of the possibilities of jurisdictional prosecution of both the perpetrators and those who formulated the legal guidance authorizing the "enhanced interrogators techniques" in both the U.S. domestic law system and international legal jurisdictional settings, including at the ICJ level. Eventually, an examination of the hasty procedure through which the new relevant Spanish provision in this area has been adopted and the legal effects, with reference to cases currently opened before the Spanish courts, of the newly reformed article give place to a brief reflection on the prospects of international law in the age of an emerging new international judiciary in view of the structural deficit of mechanisms of participatory democracy on the domestic plane with relevance in the international realm as dramatically epitomized at this juncture by the Spanish legal system.
Towards Restorative Sentencing in International Criminal Trials
Authors: Henham Ralph
Published: February 2010

This article considers how sentencing might be re-conceptualised if restorative justice became a more integral part of the rationale for international criminal trials. More specifically, it focuses on issues of admissibility and proof; trial structure; procedural justice; the role of victims and trial professionals, and the role of judicial discretionary power in sentencing decisions. The paper concludes by suggesting that change is possible by utilising judicial discretion as a force for developing more restorative trial outcomes and dealing effectively with inconsistency, appeal and the enforcement of sentences. More broadly, such changes should be seen as an opportunity for international trial outcomes to engage more directly with the challenges of facilitating transitional justice in post-conflict states.
Belongingness as a Protective Factor Against Loneliness and Potential Depression in a Multicultural Middle School
Authors: Baskin Thomas W. , Wampold Bruce E. , Quintana Stephen M. , Enright Robert D.
Published: February 2010

This study examines belongingness as a strengths-based protective factor. Belongingness is investigated in relationship to the threat of low peer acceptance for loneliness and of high loneliness for depression in adolescents. Data were collected from peers for adolescents’ peer acceptance and from adolescents themselves for other variables. Ratings of peers and self-reported survey data were analyzed together from data collected from 294 eighth-grade students from a culturally and ethnically diverse school. Results indicated belongingness was a significant moderator of the influence of peer acceptance on loneliness and of loneliness on depression. This suggests that belongingness is a potentially important buffer against the negative effects of low peer acceptance and high loneliness. Implications for counseling psychologists working with ethnically diverse adolescents are discussed.
Managing creatives: Paradoxical approaches to identity regulation
Authors: Gotsi Manto , Andriopoulos Constantine , Lewis Marianne W , Ingram Amy E
Published: February 2010

Creative workers often experience identity tensions. On the one hand, ‘creatives’ desire to see themselves as distinctive in their artistry, passion, and self-expression, nurturing an identity that energizes their innovative efforts. Yet daily pressures to meet budgets, deadlines and market demands encourage a more business-like identity that supports firm performance. Through a comparative case study of New Product Design (NPD) consultancies, we explicate the potential management of such identity tensions. Case evidence illustrates overarching, paradoxical approaches to identity regulation as the firms emphasized both differentiation and integration strategies. Differentiation practices promoted disparate identities by segregating related roles in time and space, while integration efforts encouraged a more synergistic meta-identity as ‘practical artists’. Leveraging paradox literature, we discuss how these strategies may accommodate creative workers’ needs to cope with multiple identities, as well as their aversion to sanctioned subjectivities.
Correlation of Inhibition of Platelet Aggregation With Cardiovascular and Bleeding Outcomes in Acute Coronary Syndromes
Authors: Wada Russ , Rohatagi Shashank , Small David , Winters Kenneth J. , Salazar Daniel E.
Published: February 2010

Inhibition of platelet aggregation (IPA) has been a drug development target in acute coronary syndrome (ACS) for almost 2 decades. The relationship between IPA and cardiovascular (CV) events has not been quantified. Cardiovascular (non fatal myocardial infarction, death) and major bleeding events were extracted from phase 2 or 3 randomized, double‐blind trials that evaluated oral and intravenous glycoprotein 2b/3a (GP2b/3a) antagonists and thienopyridines. IPA was extracted from different sources that studied a similar regimen in a similar population. Events were correlated to IPA using a linear relative‐risk mixed‐effects model. Covariates included type of drug, mean age, gender percentage, and ADP. Clinical trial simulations were conducted to evaluate the relationship between IPA and the likelihood of observing a CV event in a 6‐month end point trial. Data from 81918 subjects in 20 studies were extracted from the literature. To achieve a 20% relative reduction in CV events would require a further 77% (56%‐100%) absolute increase in IPA for IV GP2b/3a antagonists or a further 27%(20%‐41%) absolute increase for thienopyridines. CV risk reduction was less in studies with older subjects and greater in studies with greater percentages of male subjects. Assuming a 3% major bleeding rate in the control group, these drugs had a 1% increase in absolute risk as absolute platelet inhibition increases by 60% (range, 40%‐80%). This relationship in intrinsic bleeding may be different in different population subtypes. Assuming a 12% event rate, a 6‐month active‐controlled thienopyridine trial with 3000 subjects could detect a relationship between CV events and IPA with 80% likelihood. Target IPA increases in ACS are an absolute increase of 80% for IV GP2b/3a antagonists and 30% for thienopyridines. Quantitative models using literature data on IPA and CV events can be used to select dose regimens in early stages of drug development.