bluuebunny/crossref_metadata_2025 huggingface dataset:
English Vocabulary with a Picture Application for Enhancing Thai EFL Students’ Daily English Vocabulary Memorization
Authors: Suwanasilp Danuchawat , Durongbhandhu Nunpaporn
Published: October 2023

With the emergence of new technology, computers have been used for language learning. This experimental study aimed to develop English Vocabulary with a Picture Application (EVP) for improving students’ daily English vocabulary memorization and examine the effectiveness of EVP used between an experimental group and a control group. EVP was designed on picture mnemonic technique based on a cognitive theory of multimedia learning. The participants were 48 undergraduate students who were randomly assigned to the experimental and the control group. Prior to the intervention, the participants of both groups were given a pre-test to determine their daily English vocabulary knowledge. Then, the experimental group received EVP, and the control group went through a traditional method. After the treatment, the post-test was administrated to both groups. The results manifested that the experimental group who received EVP noticeably outperformed their counterpart in the post-test. The participants also provided positive opinions regarding the use of EVP. In consequence, the findings implied that EVP could be an optional learning tool to enhance students’ daily English vocabulary. Further study could investigate the achievement of EVP in teaching vocabulary for different purposes in various contexts.
From Pen to Pixels: Enhancing EFL Learners’ Writing Abilities Through the Use of Inquiry-Based Learning and Visual Literacy Model
Authors: Sukserm Patsawut , Wasanasomsithi Punchalee
Published: October 2023

Writing is one of the most crucial skills for EFL students and also one of the most difficult to acquire. Many students face difficulties when it comes to writing in English. To address this challenge, this study examined whether or not combining inquiry-based learning with visual literacy could enhance EFL students’ writing proficiency in four areas: content, organization, grammatical structures, and vocabulary. An intact group of 20 secondary school students from a private school in northeastern Thailand participated in this mixed-methods study, and data were collected using writing tests, student portfolios, and focus group interviews. Quantitative data were analyzed by means of descriptive and inferential statistics, while qualitative data were analyzed using content analysis. Results of the Wilcoxon signed rank test revealed a significant improvement in students’ writing scores (Z = -3.946*, p < .05) with a medium effect size after implementing the inquiry-based learning with visual literacy model. Qualitative analysis revealed that students actively engaged in the learning process, which helped enhance their writing ability. The study findings suggest that an inquiry-based learning with visual literacy model had a positive impact on EFL students’ writing ability, as evidenced by the improved quality of their written texts. This study contributes to the existing literature on the use of inquiry-based learning to enhance EFL writing ability and emphasizes the importance of visual literacy in promoting student engagement and learning outcomes.
Can Thai Students Become Self-directed Learners?
Authors: Wiriyakarun Pamararat
Published: October 2023

Recently in Thailand, there have been attempts to integrate self-directed learning into existing English programmes in a large number of institutions including King Mongkut's University of Technology Thonburi, where the importance of learner-centredness and learner self-assessment is stressed. However, questions about the possibility and effectiveness of the programmes and the students' ability to become self-directed learners have arisen. This paper will explore the students' perceptions of the effectiveness of learning through self-access to find out whether this learning mode could help improve their English proficiency.
Myth of the Native Speaker as a Model of English Proficiency
Authors: Watson Todd Richard
Published: October 2023

Although academics generally take a neutral position on the pros and cons of native speaker (NS) and non-native speaker (NNS) teachers of English, the general public perceives NS teachers as preferable because they provide a 'better' model of English. Even ignoring the arguments favouring NNS models in English as an International Language, many NS teachers do not provide a truly proficient model of English. Based on an analysis of a corpus of informal NS teacher writing, their English proficiency is dubious. The findings cast doubt on the usefulness of recent proposals to employ more NS teachers in Thai schools.
Why Investigate Large Classes?
Authors: Watson Todd Richard
Published: October 2023

This paper presents an overview of the literature on large classes in English language teaching. It presents findings concerning the size of large classes, the importance of class size, the problems of large classes and solutions to these problems. The article also provides an introduction to the other papers in this issue by discussing the context of the research reported and the issues that prompted the interest in conducting research into large classes.
prescripción en el delito de tráfico de influencias
Authors: Flores Salazar Miguel Alfredo , Labrín Pimentel Cynthia Lizbeth
Published: October 2023

Se expone una problemática que aqueja a los delitos cometidos por funcionarios o servidores públicos, como es la duplicidad de su plazo prescriptorio. Para ello, se ha empleado el método del análisis bibliográfico así como jurisprudencial, logrando concluir que, a pesar de que el referido plazo cuenta con respaldo constitucional, no estaría cumpliendo los fines del proceso penal sino, por el contrario, que la labor del fiscal estaría adoptando una suerte de comodín al confiar que los plazos son extensos para realizar su investigación, perdiendo la oportunidad de recabar prontamente los elementos de convicción que le aseguren demostrar su teoría del caso en juicio, lo cual genera que la defensa de los investigados y sus patrocinados mismos no tengan que preocuparse por una decisión oportuna del fiscal sino que a la larga incluso ese plazo extenso se venza e irremediablemente tenga que solicitarse el sobreseimiento de la causa.
Meritocracia en el ámbito académico profesional jurídico: reforma del sistema de acreditación, registro y evaluación
Authors: Bermúdez-Tapia Manuel
Published: October 2023

En el Perú no se reporta un sistema único de evaluación del perfil, de la acreditación, registro y evaluación de la carrera profesional en el ámbito de la abogacía. Es posible reportar sub niveles y procedimientos totalmente autónomos y excluyentes en el ámbito del registro de información académica, profesional y de especialización tanto en la Sunedu, en el Renacyt como a nivel de las entidades que forman parte del Ministerio de Trabajo, Servir y otras dependencias. Ante este panorama, se presenta una evaluación basada en las evidencias empíricas que se reportan a nivel de medios de comunicación que son habituales en el ámbito académico y profesional del abogado, proyectando una perspectiva negativa sobre el proceso de validación de la meritocracia que al parecer está condicionada a procedimientos complejos que finalmente desnaturalizan dicho objetivo perjudicando sobre manera el desarrollo laboral, económico y humano del abogado.
SANEAMENTO BÁSICO NO BRASIL:
Authors: Coluce Mizuta Alfredo Henrique , Rosolen Soares Ana Luiza
Published: October 2023

A universalização do saneamento básico é, há décadas, uma ambiciosa meta do governo brasileiro, que nunca foi plenamente cumprida. O acesso ao abastecimento de água, esgotamento sanitário, limpeza urbana e manejo de resíduos sólidos e drenagem e manejo das águas pluviais urbanas, é essencial para a dignidade humana, manutenção da vida e para o desenvolvimento econômico e social, garantindo saúde e qualidade de vida para a população. O novo marco regulatório, Lei nº 14.026/2020., aprovado em 2020, reorganizou as estruturas da política de saneamento brasileira, possibilitando um aumento expressivo da participação do mercado na sua gestão e orientação, transformando as lógicas que orientavam o setor. No entanto, o processo do qual o marco regulatório resulta tem suas origens na década de 90 e na interferência do FMI na política econômica brasileira, em que foram exigidos uma série de privatizações, essencialmente em nível estadual. O presente artigo almeja analisar o saneamento no Brasil e o impacto crescente da participação da iniciativa privada e do mercado financeiro neste setor. Investiga-se para este fim, a composição acionária e a distribuição de lucros das empresas de saneamento de economia mista, assim como as diferentes exposições ao mercado influenciam nas políticas de remuneração ao acionista, as formas de financiamento dos projetos de saneamento, concessões e outros meios de participação.
Extracting Land Surface Albedo from Landsat 9 Data in GEE Platform to Support Climate Change Analysis
Authors: Barletta Carlo , Capolupo Alessandra , Tarantino Eufemia
Published: October 2023

Land surface albedo is a relevant variable in many climatic, environmental, and hydrological studies; its monitoring allows researchers to identify changes on the Earth’s surface. The open satellite data that is provided by the USGS/NASA Landsat mission is quite suitable for estimating this parameter through the remote sensing technique. The purpose of this paper is to evaluate the potentialities of the new Landsat 9 data for retrieving Earth’s albedo by applying da Silva et al.’s algorithm (developed in 2016 for the Landsat 8 data) using the Google Earth Engine cloud platform and R software. Two urban areas in Southern Italy with similar geomorphologic and climatic characteristics were chosen as study sites. After obtaining thematic maps of the albedos here, a statistical analysis and comparison among the Landsat 8 and Landsat 9 results was performed considering the entire study areas and each land use/land cover class that is provided by the Copernicus Urban Atlas 2018. This approach was also applied to the data after being filtered through Tukey’s test (used to detect and remove outliers). The analysis showed a very good correlation between the Landsat 8 and Landsat 9 estimations (ρ > 0.94 for both sites), with some exceptions that were related to some mis-corresponding values. Furthermore, the Landsat 8 and Landsat 9 outliers were generally overlapping. In conclusion, da Silva et al.’s approach appears to also be reasonably applicable to the Landsat 9 data despite some radiometric differences.
Autoinhibited kinesin-1 adopts a hierarchical folding pattern
Authors: Tan Zhenyu , Yue Yang , Leprevost Felipe da Veiga , Haynes Sarah E. , Basrur Venkatesha , Nesvizhskii Alexey I. , Verhey Kristen J. , Cianfrocco Michael A.
Published: October 2023

Conventional kinesin-1 is the primary anterograde motor in cells for transporting cellular cargo. While there is a consensus that the C-terminal tail of kinesin-1 inhibits motility, the molecular architecture of a full-length autoinhibited kinesin-1 remains unknown. Here, we combine cross-linking mass spectrometry (XL-MS), electron microscopy (EM), and AlphaFold structure prediction to determine the architecture of the full-length autoinhibited kinesin-1 homodimer [kinesin-1 heavy chain (KHC)] and kinesin-1 heterotetramer [KHC bound to kinesin light chain 1 (KLC1)]. Our integrative analysis shows that kinesin-1 forms a compact, bent conformation through a break in coiled coil 3. Moreover, our XL-MS analysis demonstrates that kinesin light chains stabilize the folded inhibited state rather than inducing a new structural state. Using our structural model, we show that disruption of multiple interactions between the motor, stalk, and tail domains is required to activate the full-length kinesin-1. Our work offers a conceptual framework for understanding how cargo adaptors and microtubule-associated proteins relieve autoinhibition to promote activation.
Intuitive movement-based prosthesis control enables arm amputees to reach naturally in virtual reality
Authors: Segas Effie , Mick Sébastien , Leconte Vincent , Dubois Océane , Klotz Rémi , Cattaert Daniel , de Rugy Aymar
Published: October 2023

Impressive progress is being made in bionic limbs design and control. Yet, controlling the numerous joints of a prosthetic arm necessary to place the hand at a correct position and orientation to grasp objects remains challenging. Here, we designed an intuitive, movement-based prosthesis control that leverages natural arm coordination to predict distal joints missing in people with transhumeral limb loss based on proximal residual limb motion and knowledge of the movement goal. This control was validated on 29 participants, including seven with above-elbow limb loss, who picked and placed bottles in a wide range of locations in virtual reality, with median success rates over 99% and movement times identical to those of natural movements. This control also enabled 15 participants, including three with limb differences, to reach and grasp real objects with a robotic arm operated according to the same principle. Remarkably, this was achieved without any prior training, indicating that this control is intuitive and instantaneously usable. It could be used for phantom limb pain management in virtual reality, or to augment the reaching capabilities of invasive neural interfaces usually more focused on hand and grasp control.
Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration
Authors: Leibinger Marco , Zeitler Charlotte , Paulat Miriam , Gobrecht Philipp , Hilla Alexander , Andreadaki Anastasia , Guthoff Rainer , Fischer Dietmar
Published: October 2023

Injured axons in the central nervous system (CNS) usually fail to regenerate, causing permanent disabilities. However, the knockdown of Pten knockout or treatment of neurons with hyper-IL-6 (hIL-6) transforms neurons into a regenerative state, allowing them to regenerate axons in the injured optic nerve and spinal cord. Transneuronal delivery of hIL-6 to the injured brain stem neurons enables functional recovery after severe spinal cord injury. Here we demonstrate that the beneficial hIL-6 and Pten knockout effects on axon growth are limited by the induction of tubulin detyrosination in axonal growth cones. Hence, cotreatment with parthenolide, a compound blocking microtubule detyrosination, synergistically accelerates neurite growth of cultured murine CNS neurons and primary RGCs isolated from adult human eyes. Systemic application of the prodrug dimethylamino-parthenolide (DMAPT) facilitates axon regeneration in the injured optic nerve and spinal cord. Moreover, combinatorial treatment further improves hIL-6-induced axon regeneration and locomotor recovery after severe SCI. Thus, DMAPT facilitates functional CNS regeneration and reduces the limiting effects of pro-regenerative treatments, making it a promising drug candidate for treating CNS injuries.
Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
Authors: Howard Gregory C. , Wang Jing , Rose Kristie Lindsey , Patel Purvi , Tsui Tina , Florian Andrea C. , Lorey Shelly L. , Grieb Brian C. , Smith Brianna N. , Slota Macey J. , Reynolds Elizabeth M. , Goswami Soumita , Savona Michael R. , Lee Taekyu , Fesik Stephen W. , Liu Qi , Tansey William P.
Published: October 2023

The chromatin-associated protein WDR5 is a promising target for cancer drug discovery, with most efforts blocking an arginine-binding cavity on the protein called the “WIN” site that tethers WDR5 to chromatin. WIN site inhibitors (WINi) are active against multiple cancer cell types in vitro, the most notable of which are those derived from MLL-rearranged (MLLr) leukemias. Peptidomimetic WINi were originally proposed to inhibit MLLr cells via dysregulation of genes connected to hematopoetic stem cell expansion. Our discovery and interrogation of small molecule WIN site inhibitors, however, revealed that they act in MLLr cell lines to suppress ribosome protein gene (RPG) transcription, induce nucleolar stress, and activate p53. Because there is no precedent for an anti-cancer strategy that specifically targets RPG expression, we took an integrated multi-omics approach to further interrogate the mechanism of action of WINi in MLLr cancer cells. We show that WINi induce depletion of the stock of ribosomes, accompanied by a broad translational choke, induction of a DNA damage response, and changes in alternative mRNA splicing that inactivate the p53 antagonist MDM4. We also show that WINi are synergistic with agents including venetoclax and BET-bromodomain inhibitors. Together, these studies reinforce the concept that WINi are a novel type of ribosome-directed anti-cancer therapy and provide a resource to support their clinical implementation in MLLr leukemias and other malignancies.
Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasomeinduced blood coagulation and inflammation
Authors: Cui Jian , Li Hua , Ye Dien , Zhang Guoying , Zhang Yan , Yang Ling , Sim Martha MS , Wood Jeremy P , Wei Yinan , Li Zhenyu , Wu Congqing
Published: October 2023

Systemic blood coagulation accompanies inflammation during severe infection like sepsis and COVID. We’ve previously established a link between pyroptosis, a vital defense mechanism against infection, and coagulopathy. During pyroptosis, the formation of gasdermin-D (GSDMD) pores on the plasma membrane leads to the release of tissue factor (TF)-positive microvesicles (MVs) that are procoagulant. Mice lacking GSDMD release fewer TF MVs. However, the specific mechanisms leading from activation of GSDMD to MV release remain unclear. Plasma membrane rupture (PMR) in pyroptosis was recently reported to be actively mediated by the transmembrane protein Ninjurin-1 (NINJ1). Here we show that NINJ1 promotes procoagulant MV release during pyroptosis. Haploinsuffciency or glycine inhibition of NINJ1 limited the release of procoagulant MVs and inflammatory cytokines and partially protected against blood coagulation and lethality triggered by bacterial flagellin. Our findings suggest a crucial role for NINJ1-dependent PMR in inflammasome-induced blood coagulation and inflammation.
The pelvic organs receive no parasympathetic innervation
Authors: Sivori Margaux , Dempsey Bowen , Chettouh Zoubida , Boismoreau Franck , Ayerdi Maïlys , Eymael Annaliese , Baulande Sylvain , Lameiras Sonia , Coulpier Fanny , Delattre Olivier , Rohrer Hermann , Mirabeau Olivier , Brunet Jean-François
Published: October 2023

The pelvic organs (bladder, rectum, and sex organs) have been represented for a century as receiving autonomic innervation from two pathways – lumbar sympathetic and sacral parasympathetic – by way of a shared relay, the pelvic ganglion, conceived as an assemblage of sympathetic and parasympathetic neurons. Using single-cell RNA sequencing, we find that the mouse pelvic ganglion is made of four classes of neurons, distinct from both sympathetic and parasympathetic ones, albeit with a kinship to the former, but not the latter, through a complex genetic signature. We also show that spinal lumbar preganglionic neurons synapse in the pelvic ganglion onto equal numbers of noradrenergic and cholinergic cells, both of which therefore serve as sympathetic relays. Thus, the pelvic viscera receive no innervation from parasympathetic or typical sympathetic neurons, but instead from a divergent tail end of the sympathetic chains, in charge of its idiosyncratic functions.
Ginsenoside Rb1 enhanced immunity and altered the gut microflora in mice immunized by H1N1 influenza vaccine
Authors: Wan Chuanqi , Lu Rufeng , Zhu Chen , Wu Haibo , Shen Guannan , Yang Yang , Wu Xiaowei , Fang Bangjiang , He Yuzhou
Published: October 2023

Background

Influenza is an acute infectious respiratory disease caused by the influenza virus that seriously damages human health, and the essential way to prevent influenza is the influenza vaccine. Vaccines without adjuvants produce insufficient specific antibodies and therefore require adjuvants to boost antibody titers. Microbes and hosts are a community that needs to “promote bacteria,” which could provide new value for the immune effect.

Methods

(1) The H1N1 influenza vaccine, in combination with Ginsenoside Rb1, was co-injected into mice intraperitoneally (I.P.). Then, immunoglobulin G and antibody subtype levels were tested by enzyme-linked immunosorbent assay (ELISA). Moreover, mice were infected with a lethal dose of the H1N1 influenza virus (A/Michigan/45/2015), and survival status was recorded for 14 days. Lung tissues were stained by hematoxylin and eosin (H&E), and ELISA detected inflammatory factor expression levels. (2) Mice were immunized with Ginsenoside Rb1 combined with quadrivalent influenza inactivated vaccine(IIV4), and then IgG levels were measured by ELISA. (3) Fresh stool was collected for fecal 16S rDNA analysis.

Results

Ginsenoside Rb1 boosted IgG and antibody subtypes in the H1N1 influenza vaccine, improved survival of mice after virus challenge, attenuated lung histopathological damage, and reduced inflammatory cytokines expression in IL-6 and TNF-α. The results of 16S rDNA showed that Rb1 decreased species diversity but increased species richness compared to the PBS group and increased the abundance of Akkermansiaceae and Murbaculaceae at the Family and Genus levels compared with the HA+Alum group.

Conclusion

Ginsenoside Rb1 has a boosting effect on the immune efficacy of the H1N1 influenza vaccine and is promising as a novel adjuvant to regulate the microecological balance and achieve an anti-infective effect.
Ascophyllum nodosum-derived biostimulants modulate plant development through the regulation of hormones signaling
Authors:   , Pozo Valdés Josefa del
Published: October 2023

In agriculture, biostimulants derived from Ascophyllum nodosum extracts (ANE) have been widely used as growth stimulants and for protecting crops against biotic and abiotic stresses. Despite their widespread use, we have limited knowledge about how these biostimulants work and their role in influencing phytohormones throughout the plant. To shed light on this, we conducted a study using two commercial ANE biostimulants, Exelgrow (EG) and Exelmax (EM), which are produced through different methods. The main objective was to characterize and compare the effects of these biostimulants on the phenotype and hormonal signaling in Arabidopsis thaliana. Our findings reveal that EG and EM exhibit different biostimulant activity in Arabidopsis. Furthermore, EG promotes cytokinin (CK) signaling and suppresses auxin (AUX) signaling in the root meristem, while EM stimulates AUX and inhibits CK signaling. The transcriptomic analysis provided insights into their mechanism of action, revealing a priming effect against stress. EG interacts mainly with salicylic acid (SA) and jasmonate pathways, collectively regulating the plant's response to various biotic stresses. On the other hand, EM interacts with the brassinosteroids (BR) pathway, regulating ROS signals and defense against nematodes and pathogens. Finally, the transcriptomic analysis suggest that EM could be indirectly regulating AUX through the downregulation of BR signaling.
Nuevo suelo urbano: potencial comunitario en la normativa de Santiago Centro
Authors:   , Soto Bolaños Vicente
Published: October 2023

El panorama actual de la vivienda en Chile está fuertemente influenciado por la dinámica entre la normativa, como conjunto de reglas que dispone la manera de edificar y el mercado inmobiliario, que construye dentro de las posibilidades máximas que determina la normativa. Esta relación repercute no solo en la morfología urbana, sino también en el espacio resultante entre conjuntos de viviendas que coexisten espacial y socialmente, lo que se intensifica frente a la necesidad de densificación de los centros urbanos que impulsan la creciente complejización de dichos interiores, convirtiéndolo en un proceso recurrente de la trama urbana, producto de la superposición de decisiones proyectuales independientes. Dicha condición espacial configurada en función de intervenciones señaladas como negativas por la crítica arquitectónica, se proponen como potenciales estrategias que den solución a dicho problema, partiendo desde la premisa que actualmente la normativa favorece la escala del predio y por consecuencia, toma distancia de las posibilidades de la manzana como unidad territorial fundamental, es decir, la ciudad inmobiliaria como modelo que considera el diseño de la forma urbana, del espacio colectivo y el cambio de escala, pero desconoce el potencial de la manzana de la ciudad colonial, la ciudad neoclásica y la ciudad racional como modelos que se orientan hacia la interacción entre los conjuntos que la conforman. Frente a lo expuesto, es posible actualizar una normativa que se ha traducido en una morfología particular y fragmentaria, que puede redefinir la relación entre los dominios público y privado, mediante una serie de operaciones que integren la manzana como un conjunto de suelos comunes en aquellos estratos en donde la continuidad y el traspaso es posible.
Metaética y teoría política animal: Constructivismo, contractualismo y teoría política animal; Animales, justificación pública y equilibrio reflexivo; Coherentismo político en la teoría política.
Authors:   , Riquelme Peña Pedro
Published: October 2023

Lo que se presenta a continuación son los tres artículos que conforman la tesis. En “Constructivismo, contractualismo y teoría política animal” defiendo el constructivismo rawlsiano como el marco adecuado para desarrollar el giro político de la ética animal en un tono más bien defensivo. Respondo a las objeciones de Garner y ofrezco algunas razones en favor de este marco. En “Animales, justificación pública y equilibrio reflexivo” analizo las dificultades que tiene toda teoría política que le asigne un rol importante a la idea de la justificación pública para incluir las exigencias de los animales y presento una forma de resolverlas. La posición defendida es que, al menos en el caso de la teoría política animal, el rawlsianismo metodológico no ofrece un marco adecuado debido al rol de mera teoría de trasfondo que le asigna a la teoría social. Sostengo, en este sentido, que una teoría política animal que tome en serio las exigencias de la justificación pública debe asignarle un rol importante a la teoría social para que cumpla dos funciones: explicar las causas del estado de incoherencia de los juicios respecto a los animales en las sociedades democráticas contemporáneas e identificar un punto de partida adecuado para la reflexión normativa sobre estas cuestiones. Finalmente, en “Coherentismo político en la teoría política contemporánea” abordo el modo en que la teoría política debe hacer uso de ideas epistemológica, y postulo que, paralelo al constructivismo político, que trata, sobre todo, de cuestiones ontológicas, se debe sistematizar una teoría de la justificación pública, a la que llamo coherentismo político. Se trata de un artículo que sistematiza algunas ideas en torno a la dimensión metaética de la teoría política que aparecen sugeridas en los trabajos anteriores.
Environmental politics in Chile: Institutions, contentious action and inequality
Authors:   , Huneeus Valenzuela Luis Sebastián
Published: October 2023

esis doctoral escrita en formato de tres artículos sobre política medioambiental en Chile. En el primero, se analiza el concepto de “zona de sacrificio” (ZS) y se genera un concepto de "tres niveles", basado en una definición acotada, dimensiones definitorias e indicadores, siguiendo la metodología propuesta por Gary Goertz (Goertz, 2006). En dicho artículo también se elabora una clasificación de ZS y se ilustran las luchas de poder detrás de las ZS con dos casos icónicos de ZS en Chile, el complejo industrial en la bahía de Quintero y una ZS disputada en el norte de Chile. El segundo artículo es un estudio del Sistema de Evaluación de Impacto Ambiental (SEIA). Desde su creación, muchos proyectos aprobados por el SEIA han sido impugnados por comunidades organizadas, especialmente en el sector energético. La pregunta que guió ese artículo es si los conflictos socioambientales afectan o no en los tiempos de evaluación y las tasas de aprobación de los proyectos en evaluación, encontrando que los conflictos retrasan los proyectos, pero no los detienen. En el tercer artículo se analiza el conflicto medioambiental que tuvo lugar en Freirina entre 2011 y 2012, cuando una comunidad rural del norte de Chile se rebeló contra Agrosuper, el mayor conglomerado agro-industrial del país. Para explicar este resultado inusual, se prestó atención al rol de las amenazas, los marcos de acción colectiva y el modelo de efecto conjunto de Marco Giugni para comprender los resultados de los movimientos sociales (Giugni, 1998).
Estrategia de comunicaciones para Enel X Way: plan de acción del lineamiento estratégico: favorecer la identificación de Enel X Way en el ambiente de la electromovilidad nacional
Authors:   , Miranda Bernal Juan Mauricio
Published: October 2023

Este proyecto abordará el lineamiento estratégico Favorecer la identificación de Enel X Way en el ambiente de la electromovilidad nacional. Para esto, el plan consta de 3 etapas de acción, la Etapa 1 que se denomina Desarrollo del contenido de la marca, que incluye la construcción del relato corporativo, plan de comunicaciones, mapeo de hitos de electromovilidad, entre otros. La Etapa 2, Lanzamiento de la Marca. En esta parte del proceso, junto al lanzamiento de la marca, se apalancará con una campaña de marca para reforzar el logro de los objetivos generales. La Etapa 3 se denomina Plan de Continuidad. El objetivo es generar las acciones para continuar con el plan estratégico propuesto.
Estrategia de comunicaciones para Fundación Letra Libre: plan de comunicación externa
Authors:   , Pérez Maruri Javiera
Published: October 2023

Estrategia y plan de acciones que busca abordar, desde la comunicación externa, los problemas generados por la falta de adaptación de Fundación Letra Libre a los cambios del entorno una vez que terminaron las cuarentenas por la pandemia de COVID-19, lo cual perjudicó una actividad clave para la organización: su capacidad de convocar nuevos tutores. En este contexto, el plan propone una serie de acciones, divididas en dos dos etapas, para construir un relacionamiento con la prensa y para generar estrategias de comunicación que hagan más eficiente la difusión de nuevos mensajes considerando el nuevo entorno, con el objetivo de aumentar la visibilidad de la fundación y potenciar la convocatoria de voluntarios.
Plan de comunicación estratégica: fortalecimiento del compromiso y las relaciones del Equipo Fundación Honra
Authors:   , Garrido Sagredo Pablo
Published: October 2023

Investigación del tipo cualitativa donde se diagnostica un problema de comunicación en la organización según diferentes metodologías. Para posteriormente entregar un plan estratégico de acción a cada familia de problemas detectado en la fase de diagnóstico.
Jornadas pedagógicas, instancias valiosas dentro de los soportes pedagógicos que inciden en el bienestar docente
Authors:   , Roldán Jorquera Marianne Arlette
Published: October 2023

La educación escolar ha experimentado cambios significativos en los últimos años, y la preocupación por los docentes ha sido un tema prioritario en medio de estos constantes cambios. Centrándonos particularmente en el año 2022 y considerando el contexto de un centro educativo en la Región Metropolitana, es importante resaltar la importancia del pleno desarrollo del trabajo docente. En este sentido, se busca implementar prácticas de apoyo pedagógico que contribuyan al éxito de esta institución en la región mencionada. Dentro de esta perspectiva, este proyecto de tesis sostiene la hipótesis de que la implementación de jornadas pedagógicas planificadas entre docentes y directivos tendrá un impacto positivo en la percepción del apoyo docente dentro del centro educativo. Con el fin de probar esta hipótesis, se llevaron a cabo jornadas pedagógicas enfocadas en la comunicación efectiva entre los profesores del ciclo inicial y el equipo directivo. Como resultado, se observó un notable aumento en la satisfacción de los docentes en relación al apoyo pedagógico, lo que a su vez incrementó su compromiso y motivación diaria en el desempeño de su trabajo.
Subjetivación materna en la construcción del discurso de estudiante ideal: un estudio autoetnográfico
Authors:   , Vásquez González Mariel Francisca
Published: October 2023

En esta investigación se analiza la relación que se establece entre mi discurso de estudiante ideal y mi proceso de subjetivación materna, buscando responder a la problemática de cómo está operando dicho discurso y qué consecuencias tienen o tuvieron en un contexto de pandemia, en el cual me atribuí el rol de madre-educadora en el proceso lector de mi hija. Para poder responder a esta pregunta, se realiza una autoetnografía evocativa a través de narraciones de situaciones ocurridas en diferentes momentos de mi vida. Del análisis realizado se afirma, por un lado, que mi discurso de estudiante ideal está influenciado por el capacitismo y, por otro lado, que esas relaciones de poder capacitistas han configurado mi proceso de subjetivación materna, produciendo sentimientos de culpabilidad y autovigilancia. Posterior a ello, se discuten algunas recomendaciones para la acción profesional orientadas a problematizar de qué manera, como agentes de una institución educativa, accionamos y reproducimos este poder sobre las madres de los niños y niñas. Finalmente, se plantea mi posicionamiento profesional en torno a la relevancia de los aprendizajes adquiridos en el magíster, la experiencia realizada en el trabajo colaborativo y cómo estos se pueden transferir al ámbito profesional y educativo.
“Recién estoy aprendiendo a ser niña”: inclusión de estudiantes LGBTIQA+ en segundo ciclo: un autoestudio sobre mi experiencia docente
Authors:   , Jiménez Hernández Camila Paz
Published: October 2023

El presente estudio consiste en una revisión de mi experiencia como docente con estudiantes LGBTQIA+ con el objetivo de analizar las afectaciones que produce la norma de género, la cual recreo en base a mi memoria como profesional con 8 años de trayectoria laboral en aula con cursos de segundo ciclo y también en base a la lectura que he realizado del discurso inclusivo en esta materia de los documentos ministeriales durante los años 2022 y 2023. Para esto recopilé información a través de narrativas de autoestudio y análisis del discurso de la política pública a través de memos analíticos. Para efectuar este análisis apliqué la propuesta filosófica de Ahmed (2021) que consiste en observar el camino que construye la promesa de la felicidad en contextos neoliberales. Para esto identifiqué los objetos felices que se asocian a la promesa de la inclusión de estudiantes LGBTQIA+ y analicé la forma en que esto da como resultado la representación de los queer infelices en la escuela. Como principal hallazgo pude determinar que la presencia de estos estudiantes conlleva afectaciones relacionada con la incomodidad en distintos ámbitos, cuyo origen está principalmente en el desconocimiento del género como espacio para la libre determinación y expresión de lo humano.
El videojuego como recurso didáctico: su uso como apoyo en la generación de ficción
Authors:   , Araya Zambra Diego Jesús
Published: October 2023

El trabajo se enfoca en la implementación de una breve secuencia didáctica que busca poner a prueba el potencial del videojuego como material pedagógico, bajo la hipótesis de que impacta positivamente en la motivación de los y las estudiantes para elaborar sus tareas de la asignatura de Lengua y Literatura. Se buscó medir el antes y después de la predisposición de los y las alumnos/as frente a una tarea de escritura del género narrativo, tras pasar por la experimentación de un videojuego en la sala de clases. Los resultados arrojan una movilización de la actitud del alumnado, alejándose de la indiferencia frente a la escritura demostrada en los datos de la encuesta inicial del proceso. Se concluye que se logró movilizar positivamente la actitud de los y las estudiantes, ya que la apreciación de los alumnos cambia en el proceso, ya que ellos mismos declaran sentirse motivados gracias a la secuencia experimentada.
El grado histológico es un mejor predictor de sobrevida específico que KI67 en cáncer de mama localizado RH+/HER2-: Un estudio del mundo real
Authors:   , Constabel Butz Christine Alexandra
Published: October 2023

El cáncer de mama (CM) es el cáncer más común en mujeres. La determinación de factores pronósticos es relevante para la decisión de terapia sistémica. El objetivo del presente estudio fue determinar, en el mundo real, el rol pronóstico de Ki67 en pacientes con CM no metastásico en dos centros de cáncer; uno académico y otro de la comunidad. Se realizo un análisis retrospectivo de un registro longitudinal de pacientes con CM. Se analizaron las características clinicopatológicas y sobrevida especifica por CM (SEE) de 3.969 mujeres diagnosticadas en etapas I/II/III entre los años 2012-2021. En el análisis univariado los factores pronósticos asociados significativamente a SEE fueron: etapa, motivo de consulta (tamizaje vs síntomas), estado de receptores hormonales, grado histológico (GH) y Ki67. En el análisis multivariado, la etapa III, Ki67 20% y GH3 se asociaron significativamente a un riesgo de muerte (HR) de 4,41, 2,52 y 1,92; respectivamente, independiente del centro de tratamiento y subtipo de CM. Sin embargo, en el grupo receptor hormonal RH+/HER2- el GH presento mayor poder discriminatorio que Ki67. Las curvas ROC-AUC para Ki67 indicaron que el mejor punto de corte para SEE fue de 20%, para la cohorte completa y también para el grupo RH+/HER2-. Se concluye que el comportamiento de las variables pronosticas fue esperado y coincidente con la literatura. El GH parece ser un mejor predictor de mortalidad especifica por CM. Ki67 mostró un valor de corte consistente con lo sugerido en consensos de expertos no solo para la cohorte completa, sino también para tumores RH+/HER2-.
Proposta de reestruturação das estratégias de marketing: estudo de caso na empresa Centro Educacional Construir
Authors: Da Silva Lauany Domingas Bandeira , Gomes Taylor Vinicius da Silva , Araújo Ylana Santos , Roberto José Carlos Alves , Pinto Junior José Roberto Lira
Published: October 2023

Este artigo científico aborda uma análise organizacional da empresa Centro Educacional Construir, uma instituição de ensino situada na cidade de Manaus, estado do Amazonas. Através de um estudo de caso, foram identificados os pontos positivos e as áreas que demandam aprimoramento na empresa, além de identificar as oportunidades e desafios no mercado. A avaliação constatou que os departamentos Operacionais e Administrativo demonstram um desempenho elevado, enquanto os setores de Logística e Recursos Humanos se encontram em níveis intermediários. Em contrapartida, o setor de Marketing foi identificado como o de menor desempenho, indicando a necessidade de atenção e a implementação de melhorias nessa área. O presente artigo então, trouxe o seguinte questionamento: “Como a implantação de um planejamento de marketing pode influenciar na prospecção de novos alunos?”. O objetivo deste estudo é identificar os obstáculos enfrentados no alcance de clientes através do marketing e, posteriormente, empregar abordagens que otimizassem substancialmente o aspecto do marketing empresarial. O presente estudo adota uma abordagem qualitativa, com o propósito de analisar e compreender os dados obtidos, propondo melhorias nos seus processos, bem como nas estratégias de marketing da organização, com o intuito de alcançar uma audiência mais ampla e estimular maior engajamento dos clientes, comunicando os resultados de uma forma clara e objetiva, através de relatórios, apresentações, entre outros. Considera-se que os resultados da análise sobre o marketing digital na escola revelaram um panorama promissor e esclarecedor. A análise de dados permitiu uma compreensão mais profunda do comportamento dos alunos em potencial, possibilitando a personalização das mensagens e a captação de um público-alvo adequado. Portanto, o marketing digital desempenha um papel crucial na promoção da escola, contribuindo para o crescimento e o alcance de seus objetivos educacionais. A implantação de um planejamento de marketing emerge como um elemento crucial para o sucesso organizacional nos cenários empresariais atuais.
Prevalence of Thyroid Dysfunction in Patients with Gallstone Disease: A Cross-sectional Study
Authors: Dangi Chinmay , Mehta Nilesh , Patel Mitkumar V , Labana Urmilkumar , Patel Yashasvi , Patel Darshit Dineshbhai , Goswami Mohit Bimalbhai , Chauhan Ajay
Published: October 2023

Introduction: Patients with gallstone disease have already been investigated for the prevalence of previously undetected thyroid dysfunction, and the findings point to a possible link between hypothyroidism and gallstone disease. This research was carried out to support the need for assessment of the thyroid status in patients presenting with gallstones. Aim: To determine the prevalence of thyroid disorders and to study the relationship between thyroid dysfunction and sociodemographic variables in patients with gallstone disease. Materials and Methods: A cross-sectional, observational, hospitalbased study was carried out at Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India, in 117 patients with gallstones from January 2021 to June 2022. The sampling method was consecutive sampling. Standard baseline investigations and thyroid profiles were conducted. Operative and perioperative factors such as age (ranging from 18-80 years), sex, co-morbidities, radiological findings (number and size of stones, presence of Common Bile Duct (CBD) stones), thyroid profile, surgeries performed, and significance (p-value) of these factors were assessed based on the Chi-square test. Results: The mean age of participants was 44 years. There were 37 (68%) males and 80 (32%) females. Of the 117 patients, 49 patients (41.9%) were found to have hypothyroidism, and the remaining 68 patients (58.1%) were euthyroid. Among these 49 patients, only 15 were known to have hypothyroidism, while the remaining 34 patients were newly diagnosed. Of the 49 patients, 30 were females and 19 were males. There was no significant association between hypothyroid state and gallstone formation in either males (p-value: 0.154) or females (p-value: 0.194). Conclusion: A low prevalence of hypothyroidism was observed in both sexes. Further large population studies are needed to compare these findings.
Climate Smart Foods: Nutritional Composition and Health Benefits of Millets
Authors: Singh Rashmi , Singh Ritu , Singh Prabhat Kumar , Shivangi  , Singh Omkar
Published: October 2023

Millets are a diverse group of small-seeded grasses that have served as staple cereal crops in many parts of Asia and Africa for thousands of years. The major millets include finger millet, foxtail millet, pearl millet, proso millet, barnyard millet, little millet, and kodo millet. Millets are highly resilient crops that can thrive in arid zones and marginal farming conditions where rainfall is limited. As climate change increases drought pressures globally, millets are gaining renewed interest for their adaptability. Millets also possess highly favorable nutritional attributes. The grains are rich in protein with balanced amino acids, dietary fiber, polyphenols, vitamins, and essential minerals such as iron, zinc and calcium. The majority of millets have a low glycemic index, which helps regulate blood glucose levels. These properties give millets functional advantages over more commonly consumed cereals such as wheat and rice. This review provides a detailed analysis of the proximate composition, nutritional profile, and potential health benefits of major millets. Evidence from animal studies and clinical trials regarding the role of millets in diabetes management, cardiovascular health, cancer prevention, gut health, anemia reduction, and bone health are examined. Millets appear beneficial for weight management and obesity control Research also indicates promising avenues for millets in gluten-free diets, enhancing nutrition security for the poor, and addressing malnutrition concerns globally. However, more human studies on bioavailability, optimal dosages, food product development, and farming practices are warranted to further realize the immense potential of these “Smart Foods”. In conclusion, millets are climate-smart, nutrient-dense grains that can play a pivotal role in holistic approaches to tackle food insecurity, malnutrition, and the escalating rates of chronic diseases worldwide. Their diverse nutritional and therapeutic properties warrant the resurrection of millets as invaluable crops for the present and future.
Assessing Biases in Medical Decisions via Clinician and AI Chatbot Responses to Patient Vignettes
Authors: Kim Jiyeong , Cai Zhuo Ran , Chen Michael L. , Simard Julia F. , Linos Eleni
Published: October 2023

This cross-sectional study compares clinician and artificial intelligence (AI) chatbot responses to patient vignettes used to identify bias in medical decisions.
Race and Ethnicity and Prehospital Use of Opioid or Ketamine Analgesia in Acute Traumatic Injury
Authors: Brunson Dalton C. , Miller Kate A. , Matheson Loretta W. , Carrillo Eli
Published: October 2023

Importance

Racial and ethnic disparities in pain management have been characterized in many hospital-based settings. Painful traumatic injuries are a common reason for 911 activations of the EMS (emergency medical services) system.

Objective

To evaluate whether, among patients treated by EMS with traumatic injuries, race and ethnicity are associated with either disparate recording of pain scores or disparate administration of analgesia when a high pain score is recorded.

Design, Settings, and Participants

This cohort study included interactions from 2019 to 2021 for US patients ages 14 to 99 years who had experienced painful acute traumatic injuries and were treated and transported by an advanced life support unit following the activation of the 911 EMS system. The data were analyzed in January 2023.

Exposures

Acute painful traumatic injuries including burns.

Main Outcomes and Measures

Outcomes were the recording of a pain score and the administration of a nonoral opioid or ketamine.

Results

The study cohort included 4 781 396 EMS activations for acute traumatic injury, with a median (IQR) patient age of 59 (35-78) years (2 497 053 female [52.2%]; 31 266 American Indian or Alaskan Native [0.7%]; 59 713 Asian [1.2%]; 742 931 Black [15.5%], 411 934 Hispanic or Latino [8.6%], 10 747 Native Hawaiian or other Pacific Islander [0.2%]; 2 764 499 White [57.8%]; 16 161 multiple races [0.3%]). The analysis showed that race and ethnicity was associated with the likelihood of having a pain score recorded. Compared with White patients, American Indian and Alaskan Native patients had the lowest adjusted odds ratio (AOR) of having a pain score recorded (AOR, 0.74; 95% CI, 0.71-0.76). Among patients for whom a high pain score was recorded (between 7 and 10 out of 10), Black patients were about half as likely to receive opioid or ketamine analgesia as White patients (AOR, 0.53; 95% CI, 0.52-0.54) despite having a pain score recorded almost as frequently as White patients.

Conclusions and Relevance

In this nationwide study of patients treated by EMS for acute traumatic injuries, patients from racial or ethnic minority groups were less likely to have a pain score recorded, with Native American and Alaskan Natives the least likely to have a pain score recorded. Among patients with a high pain score, patients from racial and ethnic minority groups were also significantly less likely to receive opioid or ketamine analgesia treatment, with Black patients having the lowest adjusted odds of receiving these treatments.