bluuebunny/crossref_metadata_2025 huggingface dataset:
Seropositivity among Blood Samples Drawn from Suspected Dengue Cases at a Tertiary Care Centre of Nepal: A Descriptive Cross-sectional Study
Authors: Shreewastav Rupesh Kumar , Thakur Manoj Kumar , Singh Arambam Giridhari
Published: February 2022

Introduction: The cases of dengue fever have been reported more frequently in Nepal these days. The aim of this study was to find the prevalence of seropositivity among blood samples drawn from suspected dengue cases at a tertiary care centre of Nepal.
Methods: A descriptive cross-sectional study was conducted at a tertiary care hospital from 1st June 2017 to 31st October 2018 after getting approval from the Institutional Review Committee (Reference number: 23/2016). A total of 537 suspected dengue patients were selected for the study using convenience sampling. These dengue positive sera were assayed for their reactivity with Immunoglobulin M and Immunoglobulin G present in sera and synthetic peptides of dengue virus by enzyme linked immunosorbent assay. Data was entered and analysed in Microsoft Excel 2016. Point estimate at 95% Confidence Interval was calculated along with frequency, percentage, mean and standard deviation.
Results: Among 537 suspected dengue cases, the seropositivity for dengue was found in 124 (23.09%) (19.52-26.65 at 95% Confidence Interval) of the serum.
Conclusions: The present study revealed that dengue was more prevalent in our setting compared to similar studies. All the synthetic peptides showed reactivity with dengue-positive sera with maximum reactivity shown by RR2 peptide. In dengue-positive sera, RR2 peptide of dengue virus identified more Immunoglobulin M than Immunoglobulin G.
Bilateral Internal Carotid Arteries Occlusion: A Case Report
Authors: Upadhyaya Prabhaw , Karki Prasanna , Pokharel Baburam , Sharma Gopal Raman
Published: February 2022

Bilateral internal carotid artery occlusion is a disease that is encountered rarely. We report a case of a 54 years old female smoker, who presented with acute onset right-sided limb weakness, facial deviation and slurring of speech. On computed tomography angiography occlusion of the bilateral internal carotid artery was seen and a high-flow collateral circulation was formed through the vertebrobasilar system. Computed tomography brain perfusion showed marked cerebral hypoperfusion on the left side. The patient was thrombolysed and kept on dual antiplatelet therapy. Post-medical treatment, motor power and speech significantly improved.
Early Oral Feeding with Vascular Resection among Patients Undergoing Pancreatoduodenectomy in a Tertiary Care Hospital: A Descriptive Cross-sectional Study
Authors: Regmee Sujan , Limbu Yugal , Parajuli Anuj , Ghimire Roshan , Maharjan Dhiresh Kumar , Shrestha Suman , Thapa Prabin Bikram
Published: February 2022

Introduction: Pancreatoduodenectomy with vascular resection is performed in locally advanced periampullary malignancies. In our practice, early oral feeding is initiated in patients undergoing pancreatoduodenectomy. This study aims to find the prevalence of early oral feeding with vascular resection among patients undergoing pancreatoduodenectomy.
Methods: This was a descriptive cross-sectional study conducted among hospital records of 152 patients who underwent pancreatoduodenectomy in the department of surgery of a tertiary care hospital from 2016 to 2020. Ethical approval was taken from the Institutional Review Committee (Reference number: 0812202102). Convenience sampling was done. Patients clinical and sociodemographic data were collected and analyzed using Statistical Package for the Social Sciences version 20. Point estimate at 95% Confidence Interval was calculated along with frequency, percentage, mean, and median.
Results: Among 152 patients undergoing pancreatoduodenectomy, early oral feeding with vascular resection was done in 17 (11.18%) (6.17-16.19 at 95% Confidence Interval). Portal vein and superior mesenteric artery were resected in one (5.88%) and hepatic artery in one (5.88%) patient. Type I, III and IV reconstruction was done in nine (52.9%), five (29.41%) and one (5.88%) respectively. Clinically relevant delayed gastric emptying and postoperative pancreatic fistula were seen in two (11.7%). Complication of Clavien–Dindo Grade III or higher was seen in one (5.88%) patient. One (5.88%) mortality was noted.
Conclusions: The prevalence of early oral feeding with vascular resection among patients undergoing pancreatoduodenectomy was similar to other studies done in similar settings. Early enteral feeding is well tolerated in patients undergoing pancreatoduodenectomy with vascular resection.
Translating Korean manhwa
Authors:   Babeș-Bolyai University, BÎJA Alexandra
Published: February 2022

When translating Korean literature, we often come across words and phrases that might not have a direct equivalent in the target language. One of the most difficult genres to translate is, in our opinion, the comic, or the manhwa. We try to offer illustrative examples of translation from the source language, which is Korean, into the target language, which is English, with emphasis on translating words and phrases that might pose problems, such as culture-bound words, names of places, and characters. We will also discuss other linguistic phenomena that are common to graphic novels, such as mots expresifs, onomatopoeia, charactonyms, also tackling issues regarding historical references, cultural references, behavior, and customs pertaining to the source, but also a target, social groups. The reason why we are focusing on translating manhwa2 is the fact that it has started to become more and more popular in other cultures/countries. We chose the manhwa called 신과 함께 (Along with the Gods), as it is one of the most popular of its kind, and it is one that intertwines Korean folklore, tradition, history, and mythical creatures with contemporaneity.
Value and utility of North Korean studies in Romania
Authors:   Babeş-Bolyai University, KWAK Dong Hun
Published: February 2022

In a short period of time, Korean studies in Eastern Europe have created a great demand for education and have accumulated various research achievements. At this point, more strategic attitudes and efforts are required to find a long-term and stable growth engine of this domain. Just teaching Korean language and literature well will inevitably face the limits of the development of Korean studies, and without background knowledge of the Korean region, that is, an overall understanding of history and culture, it can be regarded as a superficial education. In this regard, it seems necessary to provide education on North Korean studies that can be said to be a part of Korean studies as a whole, to build more diverse educational contents. For example, educational contents related to North Korea will contribute to the diversity of Korean studies and will also create new demand for Korean studies education in Romania.
On the changing occupational roles of women in 20th century Korean society
Authors:   Transilvania University of Brașov, BUJA Elena
Published: February 2022

The events that occurred in the Korean peninsula in the past 100 years, such as the conversion of Koreans to Christianity, which appealed to many women especially due to the fact that “it advocated human rights, social equality, and other democratic principles” (De Mente 2017, 661), the Japanese colonization of the country (1910-1945), which granted the Korean women the right to institutional education, and the rapid growth of industry starting with the early 1960s, a phenomenon that enabled young girls to work outside their houses as soon as they graduated from high school or college were important factors in the social emancipation of Korean women. This emancipation brought with it a change in the ‘jobs’ or ‘occupations’ women had, from more traditional ones, like jungmae (matchmakers), haenyeo (sea divers), to more modern ones, such as factory workers, university professors or office employees. The current paper aims to bring to the fore these changes by making use of primary data gathered from various novels authored by Korean and American-Korean, as well as secondary data (Statistics Korea), and to show that these changes are part and parcel of women’s liberation movement. The theoretical framework employed is content analysis (Baker 1994, Cohen et al. 2018), according to which the fragments excerpted from the novels will be categorized in terms of the occupational themes. The findings of the analysis will show that despite the fact that for a long period of time Korean women were enslaved, being confined in their parents’ or in-laws’ homes, their aspirations for better jobs, mainly held by men, were fulfilled only when they achieved a certain degree of social freedom.
K-popper activism: the platform of fan activism in times of the covid-19 pandemic
Authors:   UNISINOS University (Universidade do Vale dos Sinos, BORGES de CASTILHO SACOMAN Virgine
Published: February 2022

Due to the self-isolation caused by coronavirus, K-pop fans have used social media such as Twitter in order to engage, specially, in political, racial and gender agendas. Therefore, this paper aims to investigate the demonstration and the activism of the K-pop fandom during the period of COVID-19 pandemic. In this regard, we rely on theoretical assumptions which allow us to comprehend the fandom (Hills 2017, Jenkins 2015), conceiving the activism of fandom and, mainly, the cyberactivism (Queiroz 2017), as a form of resistance (Amaral, Souza, and Monteiro 2014), which allows this theme to be allied with the reception studies (Bonin 2018, Fígaro 2000, 2009, 2019, Jacks 2015) and the data fandom (Zhang and Negus 2020). Among the demonstrations performed during COVID-19 pandemic, we highlight the support of K-poppers to the movement #BlackLivesMatter (Yang 2016) through social media as platforming elements for fan activism. Thus, this paper has made possible a reflection based on bibliographies regarding the reception of K-pop fans about the antiracist mobilizations, as well as their protagonism related to the metrics in favor of cyberactivism.
KUALITAS MANAJEMEN PADA SAAT PANDEMI COVID 19 DI DESA KEDUNGREJO, DUSUN SAMPANGAN KECAMATAN MUNCAR KABUPATEN BANYUWANGI
Authors: Ningsih Wiwik Fitria , Shidiq Riza Andriyan , WaroBheri Maria Stefania , Dewi Vivy Kurniawati , Wulandari Siskasetya , Nurhalili Reza , Oktaviana Putri
Published: February 2022

Umkm petis sari ikan tuna ARBA merupakan salah satu Umkm yang berada di Kecamatan Muncar Kabupaten Banyuwangi. Umkm ini bergerak di bidang sumber daya laut lebih tepatnya pemanfaatan Sari ikan tuna yang di produksi oleh pabrik sekitar. Petis sari ikan tuna berbahan baku air rebusan ikan tuna jadi yang di gunakan sebagai petis adalah air uap ikan bukan limbah atau minyak ikan. Banyak program yang bisa kami lakukan di UMKM tersebut sepertihalnya membantu produksi mulai awal hingga petis jadi, selain itu kami juga membantu pengemasan dan pelebelan. Pengemasan yang di gunakan di umkm tersebut ada yg di taruk plastic kecil, botol gelas dan ada juga yang di kemas di timba-timba besar, saat kita melihat logo dari umkm tersebut kurang menarik jadi kita mulai membuatkan logo agar terlihat lebih fresh dan elegan, kami pun membuatkan baner menggantikan baner yang sudah kusam dan rusak, maksud kami melakukan hal ini adalah agar pemasaran semakin meluas banyak yang tau akan umkm petis sari ikan tuna Arba ini melalui sosmed atau pun offline. Umkm tersebut memiliki karawan sebanyak 10 orang, dari 10 orang tersebut ada yang sebagai koki atau peracik, ada yang sebagi pengaduk dan bagian pembungkus bahan yang sudah jadi. Pelanggan dar iproduk petis sari ikan tuna Arba Ini sudah sampai situbondo dan bahkan pemesan banyak yang dari daerah jember.

Kata Kunci: UMKM, Pengembangan, Pemasaran
ANALYSIS THE EFFECT OF ORGANIZATIONAL COMMITMENT ISLAMIC WORK ETHICS AND ORGANIZATIONAL CULTURE ON LECTURER PERFORMANCE AT STIE MANDALA
Authors: Hidayah Tamriatin , Sulaksono Hary
Published: February 2022

This study aims to see the effect of organizational commitment variables, Islamic work ethicsand organizational culture on the performance of lecturers at STIE Mandala. The method ofcollecting data is through a questionnaire. The sampling method used a saturated sample. Thedata analysis method used is Multiple Linear Regression. The results obtained from this studyare organizational commitment has no significant influence on employee performance, Islamicwork ethics and organizational culture have a significant effect on lecturer performance at STIEMandala. The implications that can be formulated related to the results of this study are that theleadership of higher education institutions should strive to increase the organizationalcommitment of their employees, create an organizational culture that is able to create a goodwork culture.
Pengaruh Dimensi Servqual Terhadap Loyalitas Tamu Bossotel Inn, Bangkok Dengan Kepuasan Sebagai Variabel Intervening
Authors: Manggali Galuh Putri , Sulaksono Hary
Published: February 2022

This research aims to analyze servqual dimension that consisting of tangible, empathy, reliability, responsiveness, and assurance towards guest loyalty at Bossotel Inn, Bangkok, with satisfaction as an intervening variable.

This research method uses quantitative descriptive research, data collection techniques using purposive sampling by distributing 100 questionnaires to the guest of Bossotel Inn, Bangkok, the analysis method used is path analysis using SPSS version 20 and the sobel test calculator to test hypotheses.

The results of this research indicate that: 1) reliability and assurance variable have a direct effect on Bossotel Inn, Bangkok guest satisfaction. While  tangible, empathy, and responsiveness variable do not have direct effect, 2) empathy and responsiveness  variable  have  direct    effect  on  Bossotel  Inn,  Bangkok  guest loyalty, while  tangible, reliability, and assurance variable have no effect, 3) hotel guest satisfaction variable has a direct effect on   Bossotel Inn, Bangkok guest loyaltsy, and the last, 4) hotel guest satisfaction cannot be a mediate the relationship between tangible, empathy, reliability, responsiveness, and assurance towards guest loyalty at Bossotel Inn, Bangkok, Thailand.
Pengaruh Stres, Kerja Disiplin Kerja Dan Semangat Kerja Terhadap Kinerja Karyawan Ptpn XII Sumber Tengah Desa Silo, Kec.Silo Kab.Jember
Authors: Arifin Muhammad Fakri , Hidayah Tamriatin , Supeni Nely
Published: February 2022

This study aims to determine the partial and simultaneous influence of the variables of work stress, work discipline and work spirit on the performance of permanent employees of PTPN XII Sumber Tengah Desa.Silo, Kec. Silo Kab. Jember. The data used in this study were primary data in the form of data from questionnaires and secondary data in the form of vision and mission, values ​​and organizational structure which were obtained directly from PTPN XII Sumber Tengah Silo Village, Silo District, Jember Regency. The data processing method in this study uses the Research Indicator Test Analysis method, namely Validity Test and Reliability Test, Classical Assumption Test, namely Normality Test, Multicollinearity Test, Heteroscedasticity Test and Autocorrelation Test, Multiple Linear Regression, Coefficient of Determination Analysis and Hypothesis Testing, namely t-test and test F, with the help of SPSS 20 analysis tool. The results showed that the variables of work stress and work morale partially had no significant and positive effect on the performance of employees of PTPN XII Sumber Tengah Silo Village, Kec. Silo Kab. Jember and the variable work discipline partially had a significant effect and positive on the performance of employees of PTPN XII Sumber Tengah Silo Village, Kec. Silo Kab. Jember, and simultaneously the variables of work stress, work discipline and work spirit affect the performance of employees of PTPN XII Sumber Tengah Desa. Silo, Kec Silo Kab. Jember
SEPTUM INTRASINUSAL DIAGNÓSTICO PRESUNTIVO versus DIAGNÓSTICO DIFERENCIAL: REPORTE DE UN CASO.
Authors: PATIÑO-ROCHA MARÍA GABRIELA
Published: February 2022

La presencia de Septum en el seno maxilar es muy variable, pueden ser únicos, múltiples, completos, incompletos y estar localizados en diferentes zonas anatómicas, en relación a la zona de las raíces de piezas maxilares, en pacientes edéntulos o dentados, desde la zona canina ha zona de molares. Diversos autores, han descrito la prevalencia de la presencia de septum intrasinusal basados en estudios radiográficos, con resultados diferentes. El objetivo del presente artículo es diferenciar la presencia de quistes, pseudoquistes o tumores, de septums intrasinusales mediante estudios complementarios, presentando un caso clínico donde se diagnosticó un “quiste periapical” por las características radiológicas, realizado el tratamiento respectivo, cuyo estudio histopatológico dio como resultado: Mucosa Sinusal con cuadro inflamatorio crónico, abundantes eosinofilos y tejido fibroso que encapsula espícula ósea.
EXPERIENCIA DE CARIES EN ESCOLARES DE 12 AÑOS DE LLACAO CUENCA
Authors: LOARTE MERINO GUISELA JANETH
Published: February 2022

Objetivo: Determinar el Índice CPOD promedio en escolares de 12 años en la parroquia Llacao perteneciente al Cantón Cuenca en el año 2016.  Materiales y métodos: Estudio descriptivo, observacional, clínico, en 75 escolares de la parroquia Llacao de la ciudad de Cuenca, se utilizaron los criterios del índice CPOD recomendados por la OMS para el diagnóstico de caries. Resultados: El CPOD promedio de la muestra estudiada fue de 3,7 D.E. (3,2) que se considera como un nivel moderado. La prevalencia de caries dental en la población estudiada es de 76%
PRESENCIA DE QUISTES DE RETENCION MUCOSA A NIVEL DE SENOS MAXILARES, CUENCA - ECUADOR, 2016 - 2017
Authors: VERDUGO VERÓNICA IVANOVA
Published: February 2022

Objetivo: Determinar la prevalencia de los quistes de retención mucosa a nivel de los senos maxilares mediante el análisis de radiografías panorámicas digitales obtenidas y archivadas en el Centro Radiológico de la Universidad Católica de Cuenca en el período 2016-2017. Materiales y Métodos: Se trata de un estudio descriptivo, observacional, trasversal, retrospectivo. Se evaluaron 4279 radiografías panorámicas digitales. La posible relación entre la presencia de quistes de retención mucosa y la década de vida se estableció a través de la prueba de Chi Cuadrado de Pearson. Resultados: De un total de 4279 radiografías analizadas, el 4.4 % (n=189) mostró la presencia de quistes de retención mucosa en los senos maxilares. Estos quistes se presentaron con mayor frecuencia en pacientes de sexo masculino (56,6 %), y en la tercera década de vida con un porcentaje del 51 %. Además, los quistes se ubicaron en el 73,56 % de los casos a nivel del piso del seno maxilar. Conclusión: Se evidenció una prevalencia de quistes de retención mucosa baja, predominando en individuos cuyas edades oscilaban entre la tercera y cuarta década de vida. Esta prevalencia fue mayor en pacientes de sexo masculino. La localización más frecuente de estos quistes fue a nivel del piso del seno maxilar.
TÉCNICAS DE BIOLOGÍA MOLECULAR PARA LA INVESTIGACIÓN EN ODONTOLOGÍA Y BIOLOGÍA ORAL (2a PARTE)
Authors: YARZÁBAL R LUIS ANDRÉS
Published: February 2022

La Biología Molecular se dedica al estudio de la estructura y la función de dos importantes biomoléculas –proteínas y ácidos nucleicos- y de las interacciones que se establecen entre ellas. En el primer artículo de esta serie presentamos algunas de las técnicas “moleculares” y sus aplicaciones en el campo odontológico. En este segundo artículo presentamos los métodos de secuenciación de ácidos nucleicos que han permitido conocer en profundidad los detalles acerca de la forma en que se almacena y se descodifica la información genética en los seres vivos. Las secuencias obtenidas a partir del estudio de genes y genomas son útiles, no solo para identificar y clasificar seres vivos (entre los cuales microorganismos causantes de enfermedades) sino para comprender las bases genéticas de muchas enfermedades. Presentamos igualmente las estrategias de secuenciación masiva en paralelo (también llamadas Tecnologías de Secuenciación de Próxima Generación, o NGS por sus siglas en inglés) que han permitido dilucidar la compleja estructura y composición de las comunidades de microorganismos que colonizan la cavidad oral.
LA FARMACORRESISTENCIA MICROBIANA: UNA NUEVA PERSPECTIVA
Authors: RADAX JOHANN FRANZ
Published: February 2022

Esta revisión literaria analiza si el abuso de los antibióticos y el desarrollo resultante de resistencias microbianas constituyen la realidad de nuestro presente o si vivimos en el mundo “feliz” presentado en los comerciales. Se realizó una búsqueda inicial por clústeres en el internet y subsiguientes búsquedas adicionales según el principio de bola de nieve. El uso de los antibióticos ha aumentado en las últimas décadas. En los EEUU el 80% de estas substancias se destina a la agricultura y ganadería, especialmente para fines profilácticos y como promotores de crecimiento. Mediante ejemplos se comprueba que no existe unaseparación real entre los antibióticos para el uso veterinario y aquellos para el uso humano. Varios estudios internacionales (Europa, Norteamérica, Brasil) determinaron la presencia de bacterias multirresistentes en animales de granja y personas expuestas. Una prohibición en la Unión Europea del uso de antibióticos para la profilaxis y la promoción del crecimiento en la ganadería no surtió efectos satisfactorios. Se informa el problema de los antibióticos en productos alimenticios y en el suelo y los resultados de estudios locales sobre la contaminación de alimentos con antibióticos y gérmenes resistentes. Las grandes farmacéuticas abandonan el desarrollo de nuevos antibióticos por no constituir un modelo económico atractivo. Se critica eluso indiscriminado de “antibióticos de reserva” en la producción ganadera. El uso de los antibióticos en la odontología es sometido a una evaluación. Se presenta la lista de recomendaciones emitida por la Sociedad Americana de Enfermedades Infecciosas y se amplía la lista por varios puntos para adaptarla a la realidad del Ecuador. Se advierte de que se está agotando el tiempo que queda para actuar.
NORMAS PARA AUTORES
Authors: OActiva Revista
Published: February 2022

La revista O-Activa de la carrera de Odontología fue creada en el año 2015; indexada en LATINDEX- CATÁLOGO v2.0en el año 2018 con un puntaje 38/38, pertenece a la Unidad Académica de Salud y Bienestar de la Universidad Católicade Cuenca. Es un órgano de difusión científica que pretende divulgar todo tipo de trabajos con el objetivo fundamentalde transmitir el conocimiento dentro del área odontológica, en el cual se incluyen temas de actualidad y relevancia como:Epidemiología, Operatoria Dental, Materiales dentales, Radiología Maxilofacial, Cirugía Bucal y Maxilofacial, Ortodonciay Ortopedia Maxilar, Odontopediatría, Periodoncia e Implantología, Endodoncia, Rehabilitación Oral, Patología Bucal,Odontología Forense, Salud Pública, entre otros tantos aspecto médicos relacionados con la Odontología. La revista estádirigida a todos los investigadores, docentes, profesionales y estudiantes no solo de la especialidad, sino también del área delas Ciencias de la Salud en general. De esta forma se contribuye al fortalecimiento, discusión e intercambio de conocimientos,proporcionando con ello información que sirva de base para el desarrollo profesional y la formación continua. La presenteguía consta de cuatro partes: tipología de artículos a publicar, requisitos para preparar un manuscrito, instrucciones para lapreparación de las secciones del manuscrito y proceso de evluación por pares.
PREVALENCIA DE ENFERMEDAD PERIODONTAL, EN ESCOLARES DE 12 AÑOS DE LA PARROQUIA BELLAVISTA,CUENCA 2016.
Authors: Cajamarca Pablo
Published: February 2022

Objetivo:Determinar la prevalencia de la enfermedad periodontal en escolares de 12 años de edad, de la ParroquiaBellavista del cantón Cuenca, Ecuador.Materiales y métodos:Se realizó una investigación de tipo transversal, cuantitativoy retrospectivo. El tamaño de la muestra fue de 114 escolares de 12 años. Se evaluó la presencia de la enfermedadperiodontal mediante el cálculo del índice de Russell.Resultados:La prevalencia de enfermedad periodontal fue de 32,46 %,predominando el sexo femenino. De acuerdo con la arcada más afectada fue la inferior con 53,46 %; y según el lado el derechofue el que más prevaleció con 51.35 %.Conclusión:La enfermeda periodontal se confirma en estados tempranos las cualesno son diagnosticados ni tratados, convirtiéndola en una de las enfermedades más crónicas a nivel mundial y a más que segúnel estudio verificamos que por lado afectado un hallazgo de una masticación unilateral derecha.
PERFIL EPIDEMIOLÓGICO DE FISURA LABIO ALVEOLO PALATINA EN PACIENTES 0 A 14 AÑOS DE EDAD DE UN HOSPITAL DE CUENCA.
Authors: Cazar Marcelo
Published: February 2022

Objetivo. Determinar la frecuencia de ocurrencia de Fisura labio alveolo palatina en fichas de pacientes pediátricos de 0 a 14 años de edad en el Hospital José Carrasco Arteaga (HJCA), Instituto Ecuatoriano de Seguridad Social (IESS) de la ciudad de Cuenca en el periodo comprendido entre el 2015 y el 2017. Metodología. Se realizó un estudio descriptivo observacional de corte transversal, mediante la revisión de 28016 fichas clínicas de pacientes pediátricos de 0 a 14 años de edad, del Hospital José Carrasco Arteaga. Se revisaron aquellas que presentaron la patología, mediante un formulario de recolección de datos desarrollado por el equipo de investigación. Resultados. Se observó un 0,06 % de prevalencia de Fisura labio alveolo palatina en pacientes pediátricos de 0 a 14 años de edad. Se encontraron en mayor número en pacientes de sexo masculino = 72,2 %, con respecto a pacientes del sexo femenino = 27,8 %. Conclusión. La frecuencia de ocurrencia de fisura labio alveolo palatina en el Hospital José Carrasco Arteaga IESS, en el periodo 2015 - 2017 se encuentra dentro del rango promedio en Latinoamérica que va desde 0,05 al 0,15 %.
GUÍA PARA AUTORES Y NORMAS DE PUBLICACIÓN
Authors: OActiva Revista
Published: February 2022

La revista O-Activa de la carrera de Odontología fue creada en el año 2015; indexada en LATINDEX- CATÁLOGO v2.0

en el año 2018 con un puntaje 38/38, pertenece a la Unidad Académica de Salud y Bienestar de la Universidad Católica

de Cuenca. Es un órgano de difusión científica que pretende divulgar todo tipo de trabajos con el objetivo fundamental

de transmitir el conocimiento dentro del área odontológica, en el cual se incluyen temas de actualidad y relevancia como:

Epidemiología, Operatoria Dental, Materiales dentales, Radiología Maxilofacial, Cirugía Bucal y Maxilofacial, Ortodoncia

y Ortopedia Maxilar, Odontopediatría, Periodoncia e Implantología, Endodoncia, Rehabilitación Oral, Patología Bucal,

Odontología Forense, Salud Pública, entre otros tantos aspecto médicos relacionados con la Odontología. La revista está

dirigida a todos los investigadores, docentes, profesionales y estudiantes no solo de la especialidad, sino también del área de

las Ciencias de la Salud en general. De esta forma se contribuye al fortalecimiento, discusión e intercambio de conocimientos,

proporcionando con ello información que sirva de base para el desarrollo profesional y la formación continua. La presente

guía consta de cuatro partes: tipología de artículos a publicar, requisitos para preparar un manuscrito, instrucciones para la

preparación de las secciones del manuscrito y proceso de evaluación por pares.
Extracciones múltiples en el contexto del COVID 19: Reporte de caso clínico de un cuarto molar
Authors: Zhingre Suárez Mauricio Rubén
Published: February 2022

El cuarto molar también llamado distomolar o retromolar por su localización distal o posterior a los terceros molares, es una variante de número y forma que se presenta durante la odontogénesis. Mediante el presente caso clínico se trató a una paciente de sexo femenino de 22 años de edad que acude a la consulta odontológica de la facultad de odontología de la Universidad de Cuenca, con la necesidad de que se le extrajeran los terceros molares en una sola cita debido a las limitaciones del COVID-19 y en la cual se encontró la presencia de un cuarto molar en la exploración radiológica. Dentro del procedimiento se recurrió a la técnica de osteotomía para la extracción quirúrgica del cuarto molar con el propósito de prevenir el desplazamiento hacia el seno maxilar, además se consideró la complementación de antibióticos a la terapia analgésica para minimizar las posibles complicaciones postoperatorias. Posterior al procedimiento quirúrgico se realizaron seguimientos a través de teleodontología de carácter consultivo mediante llamada telefónica con el fin de supervisar la ingesta adecuada de medicamentos y verificar la evolución del paciente.
Cardiac arrhythmias in new coronavirus infection (COVID-19)
Authors:   Kazan State Medical University, KHAZOVA E. V. , VALIAKHMETOV R. V. ,   Kazan State Medical University, BULASHOVA O. V. ,   Kazan State Medical University, MALKOVA M. I. ,   Kazan State Medical University
Published: February 2022

The article presents a literary review of the effect of the new coronavirus infection (COVID-19) on the cardiovascular system, namely cardiac arrhythmias. Probable etiopathogenetic factors of arrhythmia formation in patients with COVID-19 infections are described. The analysis of clinical forms of rhythm disturbances in patients with COVID-19 is presented. It was found that the probability of developing arrhythmias is associated with the patient’s age, their stay in an intensive care unit, and the presence of comorbid pathology. The data of foreign authors who note such rhythm disturbances as atrial fibrillation and fluttering, ventricular tachycardia, and high degree intermittent atrioventricular blockade as the most common among patients with a new coronavirus infection are presented. There was an association between malignant arrhythmias, including ventricular tachycardia / ventricular fibrillation and an increase in troponin T levels compared to patients with normal troponin T levels. The problem of side effects of the drugs used in COVID-19 treatment, namely arrhythmias, is stated. The dependence is shown between concomitant diseases, low PaO2/FiO2 balance and occurrence of arrhythmias in the form of a new atrial fibrillation.
Low birth weight and cardiovascular disorders in children and adults
Authors:   Kazan State Medical University, OSLOPOV V. N. , VAFINA A. A. ,   Kazan State Medical University, KUSHCHEVA A. V. ,   Kazan State Medical University, KHAZOVA E. V. ,   Kazan State Medical University, OSLOPOVA YU. V. ,   Kazan (Volga Region) Federal University
Published: February 2022

Low birth weight children are an urgent problem of modern health care. Children born with low birth weight are at high risk of developing cardiovascular diseases. The article describes new ideas about the birth of children with prenatal malnutrition, its classification, and the reasons for the birth of infants with low body weight (less than 2500 g). Studies have shown that low birth weight was directly associated with an increased risk of hypertension, coronary heart disease and stroke, while high birth weight was associated with an increased risk of atrial fibrillation in adults. There is data demonstrating a J-shaped dependence of body weight at birth with the risk of developing diabetes mellitus and cardiovascular diseases, while this relationship is more pronounced in women.
Significance of determining the body’s adrenergic reactivity in patients with chronic heart failure
Authors:   Kazan State Medical University, KHAZOVA E. V. , BULASHOVA O. V. ,   Kazan State Medical University
Published: February 2022

The article provides an overview of the studies of sympathoadrenal system activity in the patients of cardiovascular continuum. The analyzed publications show an excess of β-APM in patients with arterial hypertension, ischemic heart disease, rhythm disturbances, and heart failure in comparison with healthy individuals. The features of the course and development of cardiovascular system complications in patients with myocardial infarction at various β-APM levels are shown. The dynamics of β-APM level was demonstrated in patients with resistant hypertension after renal denervation and patients with myocardial infarction during a year. The level of β-ARM ≥ 49,53 conv. units is revealed at which the risk of CHF progression increases in patients with MI (OR 5,48; 95% CI 1,28–23,37; p = 0,024). Correlations of β-APM value with SHORC, heart rate, data of a 6-minute walking test in CHF patients are presented. The data of the β-APM and polymorphism of the ADRB1 and ADRB2 genes studies are presented. The prognostic significance of determining the adrenergic reactivity by the value of β-adrenergic reception of cell membranes for determining the individual sensitivity of the organism to β-adrenergic blockers is shown. The associations obtained suggest a genetic predisposition to SAS hyperactivation and β-APM use for personalized selection of the β-adrenergic blocker dosage.
Influence of nutrition on the bone system in children
Authors:   Kazan (Volga) Federal University, MANSUROVA G. SH. , MALTSEV S. V. ,   Russian Medical Academy of Continuous Professional Education, MANSUROVA D. M. ,   Humanitas University
Published: February 2022

The article presents a review of data on the influence of nutrition on the formation of bone system in children and adolescents. The results of modern research and meta-analyzes are shown, which demonstrate the role of rational balanced nutrition on the skeleton growth and accumulation of peal bone mass in children. The main trends of the contemporary children’ food behavior are shown. The influence of the «western» nutrition type on various areas of bone pathology in the recent 20 years are estimated. The research results are presented, which showed the correlation between nutrition regime, bone mineral density and the risk of fractures in various age groups. New data are given about the regulatory influence of the intestine microbiome on the bone tissue health.
Congenital anomalies of kidneys and urinary tract in children as an urgent problem in pediatrics
Authors:   Samara State Medical University, MAKOVETSKAYA G. A. , MAZUR L. I. ,   Samara State Medical University, KURSHINA M. V. ,   Samara State Medical University, PYRKOVA S. A. ,   Samara State Medical University, RESHETOVA S. N. ,   Samara State Medical University
Published: February 2022

The review systematizes the current data on congenital anomalies of kidneys and urinary tract (СAKUT), which are a common and main cause of chronic kidney disease, end-stage renal failure, disability at an early and older age in children. The article provides up-to-date information on the most common methods for assessing kidney damage in the fetus and children. The review outlines the current achievements in the study of etiopathogenesis, clinical picture, diagnosis with an emphasis on early prenatal detection. The data on the genetic basis of diseases, including in sporadic cases of CAKUT, are presented. The features of using genetic information in a clinical setting for the development of personalized medicine are reflected. The clinical significance of the use of biomarkers, genetic testing in kidney disease in children is shown. The issues of continuity between specialists are stated, as well as those of the importance of medical and genetic counseling of families, ethical aspects of congenital anomalies of the urinary system in children, and prevention. The purpose is to summarize the modern data related to the etiopathogenesis, prenatal diagnostics and genetic basis of CAKUT syndrome, and the importance of genome and post-genome technologies for the development of personalized medicine.
Is it necessary to get rid of the eponyms of Nazi doctors?
Authors:   Kazan State Medical University, OSLOPOV V. N. , KUSHCHEVA A. V. ,   Kazan State Medical University, TOMASH K. S. ,   Kazan State Medical University, OSLOPOVA YU. V. ,   Kazan (Volga Region) Federal University
Published: February 2022

Hippocrates said: «Whoever succeeds in the sciences and lags behind in morality is more harmful than useful». The activities of doctors are a feat, a great sacrifice. This became especially evident now, during a new coronavirus infection, when doctors, saving the lives of others, died in line of duty. However, in the history of medicine there were also monster doctors who committed terrible acts to people. For example, during the World War II, Japanese doctors in Unit 731 became notorious (their names are known in politics, but they did not enter the history of medicine), as well as a Nazi doctor Josef Mengele, nicknamed Angel of Death. There also were doctors who were both scientists and ruthless killers. Among them are the German doctors who, having made a great contribution to medicine, in wartime became adherents of Nazi ideology and made brutal experiments on people (their names are preserved in medicine as eponyms of diseases discovered by them). The article outlines the historical facts of wartime medical and scientific activity, as well as our opinion on the still open question: should the diseases bear the eponyms of Nazi doctors, whose names have been preserved in history as «scientists» who lost their human appearance?
Features of atherosclerotic lesion of coronary arteries in patients with early development of acute coronary syndrome among the carriers of various polymorphic angiogenesis genes
Authors:   Kazan State Medical University, IVANTSOV E. N. , KHASANOV N. R. ,   Kazan State Medical University
Published: February 2022

The purpose was to examine atherosclerotic changes in the anatomy of coronary arteries in patients with early acute coronary syndrome among carriers of different genotypes: rs3825807 of the ADAMTS7 gene and rs699947 of the VEGF-A gene.The study included 116 patients, 69 (59%) men and 47 (41%) women with the first manifestation of acute coronary syndrome (ACS) before 55 years and 65 years respectively. Coronary angiography revealed at least one stenosis ≥ 40% in all patients during in-house treatment. The genotype of rs3825807 ADAMTS7 gene and rs699947 VEGF-A gene was determined by PCR in all patients. The prevalence of CC genotype rs699947 VEGF-A gene in patients with left circumflex artery stenosis was less than in patients without such a lesion (0.26 versus 0.46, p = 0,03; OR = 0,419; 95% CI: 0,187–0,941). The prevalence of TT genotype rs3825807 ADAMTS7 gene in patients with early manifestation of ACS with stenosis of the posterior basal branch and posterior interventricular branch of the right coronary artery was significantly higher (0,78 versus 0,35, p = 0,027) than in patients without these lesions (OR = 6,36; 95% CI: 1,27–32,59). Thus, with the development of acute coronary syndrome in men up to 55 years old, in women up to 65 years old, the carriage of the Аallele rs699947 VEGF-A gene is associated with lesions of left circumflex artery, and the carriage of TT genotype rs3825807 ADAMTS7 gene is associated with lesions of the posterior interventricular branch and the posterior basal branch of the right coronary artery.
Features of pre-diagnostic period of medulloblastoma clinical manifestations in children in the Republic of Tatarstan
Authors:   Kazan State Medical University, VOLKOVA A. R. , VAKHITOV KH. M. ,   Kazan State Medical University, KUMIROVA E. V. ,   Morozov Children’s Clinical Hospital, MAKHMUTOVA A. G. ,   Kazan State Medical University
Published: February 2022

The article provides up-to-date information on the first clinical symptoms of brain tumors in children and considers the term «pre-diagnostic symptomatic interval» of pediatric medulloblastoma, which is widely used in foreign pediatric and neuro-oncological practice. The authors publish the results of their own retrospective population study revealing the clinical and epidemiological characteristics of the most frequently detected malignant brain tumors in children — medulloblastomas in the pediatric population of the Republic of Tatarstan. The analysis of the pre-diagnostic symptomatic interval of this pathology was carried out through the prism of the LOWorPAY scheme, recommended by neurooncologists as a guide for early detection of tumors for primary care physicians. A probabilistic model of the clinical symptom complex is proposed, which determines the risk of neoplasm of the central nervous system in children. Its use will help increase the oncological alertness of doctors and systematize the tactics of detecting brain and spinal cord tumors in children on an outpatient basis.
Hubungan Kolerasi antara Motivasi Kunjungan, Karakteristik, dan Kegiatan di Toko Kopi
Authors: Savitri Rika
Published: February 2022

Jumlah toko kopi di berbagai daerah di Indonesia semakin meningkat. Setiap toko kopi memiliki karakteristik yang berbeda dan didatangi oleh segmen pengunjung yang berbeda pula. Tujuan penelitian ini dilakukan untuk mengetahui hubungan korelasional antara motivasi kunjungan, karakteristik toko kopi, dan kegiatan yang terjadi di dalam toko kopi. Penelitian dilakukan dalam dua tahapan, yaitu tahap pertama penelitian kualitatif eksploratif dengan pendekatan grounded theory dan tahap ke-dua penelitian kuantitatif eksplanatori dengan pendekatan korelasional. Data penelitian tahap pertama dikumpulkan dengan kuesioner daring terbuka dan dianalisis dengan conventional content analysis. Data penelitian tahap ke-dua dikumpulkan dengan kuesioner daring tertutup dan dianalisis menggunakan analisis faktor (factor analysis) dan analisis korelasi multivariat (multivariate correlation analysis). Dari hasil analisis terungkap lima pola hubungan korelasional antara motivasi, karakteristik, dan kegiatan, yaitu gratifikasi, sosialisasi, keterjangkauan, peran untuk orang lain (POL), dan pencapaian tujuan.
Asymptotic expansion for the solution of a convection-diffusion problem in a thin graph-like junction
Authors: Mel’nyk Taras A. , Klevtsovskiy Arsen V.
Published: February 2022

A steady-state convection-diffusion problem with a small diffusion of order [Formula: see text] is considered in a thin three-dimensional graph-like junction consisting of thin cylinders connected through a domain (node) of diameter [Formula: see text], where ε is a small parameter. Using multiscale analysis, the asymptotic expansion for the solution is constructed and justified. The asymptotic estimates in the norm of Sobolev space [Formula: see text] as well as in the uniform norm are proved for the difference between the solution and proposed approximations with a predetermined accuracy with respect to the degree of ε.
Immunological characteristics of human umbilical cord mesenchymal stem cells after hepatogenic differentiation
Authors: Yin Yanfeng , Hu Zongqiang , Guan Zheng , Lv Sha , Wang Yiyin , Su Wenjun , Yan Chuntao , Wang Yiting , Ma Li , Jiang Jie , Feng Shiming , Li Li
Published: February 2022

BACKGROUND: Acute liver failure is one of the most intractable clinical problems. The use of bioartificial livers may solve donor shortage problems. Human umbilical cord mesenchymal stem cells (hUCMSCs) are an excellent seed cell choice for artificial livers because they change their characteristics to resemble hepatocyte-like cells (HLCs) following artificial liver transplantation. OBJECTIVE: This study aimed to determine whether the immunological characteristics of hUCMSCs are changed after being transformed into hepatocyte-like cells. METHODS: HUCMSCs were isolated by the adherent method. The following hUCMSC surface markers were detected using flow cytometry: CD45, CD90, CD105, CD34, and octamer-binding transcription factor 4 (OCT-4). Functional detection of adipogenic differentiation was performed. The hUCMSCs were cultured in complete medium (control group) or induction medium (induction group), and flow cytometry was used to detect cell surface markers. Peritoneal lavage fluid was collected after intraperitoneal injection of 1 × 106 cells/mouse over 40 minutes. The leukocyte count, labeled CD45, CD3, CD4 and CD8 antibodies, and flow detection of T lymphocyte subsets were determined using the peritoneal lavage fluid. RESULTS: Using phenotypic and functional identification, hUCMSCs were successfully isolated using a two-step induction method. The surface markers of the hUCMSCs cells changed after HLC induction. In vivo immune results showed that hUCMSCs and HLsC induced leukocyte production. CONCLUSION: Hepatic induction of hUCMSCs changes their cell surface markers. Both HLCs and hUCMSCs cause leukocytosis in vivo, but the immune response induced by HLCs is slightly stronger.
Human-derived decellularized extracellular matrix scaffold incorporating autologous bone marrow stem cells from patients with congenital heart disease for cardiac tissue engineering
Authors: Gao Liping , Li Xuexia , Tan Rubin , Cui Jie , Schmull Sebastian
Published: February 2022

BACKGROUND: Stem cells are used as an alternative treatment option for patients with congenital heart disease (CHD) due to their regenerative potential, but they are subject to low retention rate in the injured myocardium. Also, the diseased microenvironment in the injured myocardium may not provide healthy cues for optimal stem cell function. OBJECTIVE: In this study, we prepared a novel human-derived cardiac scaffold to improve the functional behaviors of stem cells. METHODS: Decellularized extracellular matrix (ECM) scaffolds were fabricated by removing cells of human-derived cardiac appendage tissues. Then, bone marrow c-kit+ progenitor cells from patients with congenital heart disease were seeded on the cardiac ECM scaffolds. Cell adhesion, survival, proliferation and cardiac differentiation on human cardiac decellularized ECM scaffold were evaluated in vitro. Label-free mass spectrometry was applied to analyze cardiac ECM proteins regulating cell behaviors. RESULTS: It was shown that cardiac ECM scaffolds promoted stem cell adhesion and proliferation. Importantly, bone marrow c-kit+ progenitor cells cultured on cardiac ECM scaffold for 14 days differentiated into cardiomyocyte-like cells without supplement with any inducible factors, as confirmed by the increased protein level of Gata4 and upregulated gene levels of Gata4, Nkx2.5, and cTnT. Proteomic analysis showed the proteins in cardiac ECM functioned in multiple biological activities, including regulation of cell proliferation, regulation of cell differentiation, and cardiovascular system development. CONCLUSION: The human-derived cardiac scaffold constructed in this study may help repair the damaged myocardium and hold great potential for tissue engineering application in pediatric patients with CHD.
Physical activity in patients with amyotrophic lateral sclerosis: Prevalence, patients’ perspectives and relation to the motor performance
Authors: Sznajder Jan , Barć Krzysztof , Kuźma-Kozakiewicz Magdalena
Published: February 2022

BACKGROUND: There are no recommendations for physical activity in amyotrophic lateral sclerosis (ALS) patients. OBJECTIVE: (i) To describe the prevalence and pattern of physical activity (PA) in ALS patients; (ii) to explore patients’ attitude towards PA; and (iii) to investigate the relationship between PA at home environment and the rate of functional decline. METHODS: 96 ALS patients were followed for 6 months at 3-month intervals and assessed by site of disease onset, disease duration, diagnosis delay, functional status, muscle strength, fatigue and prevalence of PA. RESULTS: Over 70% of patients performed regular exercise and reported a positive effect of PA on functional status and mood. Regularly exercising individuals showed a higher ALSFRS-R bulbar score (11.0 vs 9.0, p = 0.011) and a lower decline of respiratory sub-score of ALSFRS-R compared to non-regularly exercising patients (0 vs 1.0, p = 0.026). Bulbar onset was a negative prognostic factor for regular exercise (odds ratio [OR]: 5.2, p = 0.004). CONCLUSION: The majority of ALS patients perform regular PA and find it positively influence their motor performance and mood. Bulbar disease onset, but not functional status, is a negative prognostic factor for regular exercise in ALS patients. Regular mild PA may result in a slower deterioration of functional status, especially the respiratory function.