bluuebunny/crossref_metadata_2025 huggingface dataset:
Praenatalisan felismert magzati aortaív-rendellenességek és megszületés utáni következményeik
Authors: Tidrenczel Zsolt , P. Tardy Erika , Ladányi Anikó , Hajdú Júlia , Böjtös Ildikó , Sarkadi Edina , Simon Judit , Demeter János
Published: July 2023

Bevezetés: Az aortaív magzati rendellenességei gyakran társulnak
a szív és egyéb szervek eltéréseivel, kromoszómaaberrációkkal és a
légcső/nyelőcső postpartum kompressziós tüneteivel. Célkitűzés:
Tanulmányunk az aortaív-rendellenességek intrauterin kimutatását, a társuló
malformációk, a genetikai eltérések és a megszületés utáni következmények
vizsgálatát célozta. Módszer: Retrospektív kohorsztanulmány egy
hazai tercier praenatalis centrumban, szülészeti és magzati kardiológiai
ultrahangvizsgálattal 2016 és 2020 között igazolt aortaív-rendellenességekben. A
genetikai vizsgálat kariotipizálással és fluoreszcens in situ
hibridizációval történt. A születés utáni következményeket a megszületést követő
24 hónapig vizsgáltuk. Eredmények: Összesen 11 380 várandós nő
vizsgálata során a magzati aortaív-eltérés prevalenciája 0,25% volt. A 28
igazolt jobb oldali aortaív-esetből 27 esetben genetikai vizsgálat is történt. A
magzati ultrahangvizsgálat során jobb oldali V jel 4 magzatnál, a többi esetben
pedig U jel volt látható, melyből 4 esetben teljes kettős aortaív igazolódott. A
jobb oldali aortaív 18 esetben (67%) volt izolált. A társult rendellenesség 3
esetben cardialis, 7 esetben extracardialis volt. A leggyakoribb szíveltérés a
Fallot-tetralógia (2/27), a leggyakoribb extracardialis eltérés a
thymushypoplasia, az arteria (a.) umbilicalis singularis és az a. subclavia
eltérései voltak. DiGeorge-szindrómát 1 esetben (3,7%) igazoltunk. A jobb oldali
V-jel-esetek 75%-a conotruncalis szívrendellenességgel társult. A terhesség
kimenetele és a postpartum következmények 24 esetben (89%) voltak ismertek. A
postnatalis diagnózis 2 esetben tért el a praenatalistól, a diagnózis
konkordanciája 93% volt. Az izolált esetek 17/18 terhességben élve születéssel
végződtek. Születés utáni kompressziós tünet 9 esetben (42,9%) alakult ki
vascularis ring miatt, 6 gyermeknél (28,6%) műtétre is szükség volt.
Következtetés: A magzati aortaív-betegségek
multidiszciplináris kórképek, melyek megfelelő ultrahangvizsgálati módszerek
alkalmazásával méhen belül felismerhetők. A társuló szervi rendellenességek
miatt alapos szülészeti és kardiológiai magzati ultrahangvizsgálat javasolt, a
genetikai betegségek miatt invazív beavatkozás és a megszületés után speciális
követés indokolt. Orv Hetil. 2023; 164(28): 1111–1120.
Habana año cero, el Período Especial y la literatura cubana post-soviética: un diálogo con Karla Suárez
Authors: García-Arango Lis , García-Rivera René Camilo
Published: July 2023

En una de las pausas de la pandemia, en esas breves brechas donde suspenden las restricciones al ocio y la movilidad, dialogamos en Lisboa con la escritora cubana Karla Suárez (La Habana, 1969), una de las voces representativas de la narrativa insular contemporánea, quien cuenta en su haber con las novelas Silencios (Lengua de trapo, 1999), La viajera (Roca Editorial, 2005), Habana año cero (Quetzal Editores, 2011) y El hijo del héroe (Editorial Comba, 2017). En 2019, Karla Suárez recibió el Premio Iberoamericano Julio Cortázar por el cuento “El pañuelo”. La crítica ha caracterizado su prosa como “clara y venturosa” (2018, s.p.) –al decir de Francisco Solano en el diario español El País–. Por su parte, la investigadora Luisa Campuzano (2013) consideró que la autora “aporta a la novelística cubana postsoviética un nuevo decir” (s.p.), y enfatizó la “efectividad expresiva, la gran economía de medios, la moderación y la distancia” presentes en su estilo.
Épített tér – alkalmazkodás és tér-tárgy összefüggés óvodai környezetben
Authors: Mucsi Zsuzsanna , Molnár László
Published: July 2023

The inner motivation of children is learning. Their lives take place in the present, their focus is on the events of the moment. They are constantly adapting to the world around them, meaning they are instinctively “grow” the space. Learning is ideal for an aesthetically pleasing and emotionally comfortable, flexibly changing environment where the spatial world can help a child’s physical, mental and emotional development. The dissertation provides an overview of the architectural and interior design tools that can be used to help the acquisition and application of appropriate spatial mental operations in a preschool environment. It deals with the spatial-material relations that develop the body scheme and personal physical space, as well as spatial orientation. It also examines the spatial structures that stimulate movement and the toys, objects, equipment, and furniture that focus on the development of the senses.
Commercial training for women in Nemzeti Nőnevelés
Authors: Stummer Krisztina
Published: July 2023

The rarely examined educational institution of the first part of the 20th century is the women’s upper commercial school. During this period, it received countless criticism due to its curriculum. In spite of being a girls’ school, the typical ‘women’s subjects’ were not included in the timetable. The aim of this study is to demonstrate the views on this kind of school in the issues of the journal Nemzeti Nőnevelés (National Female Education) between the years of 1909 and 1919. We are interested in the person of the author in the different issues, his/her relationship towards the given type of school, and in what sort of opinion he/she had.
Linking Workplace Exclusion with Employees’ Intention to Leave with the Mediating and Moderating Role of Self-esteem
Authors: ERTOP Dilşah , ERDOĞAN Muhammed Esat
Published: July 2023

This study aims to investigate the relationship between workplace exclusion and intention to leave with the mediating and moderating role of self-esteem. Data was collected from 200 white-collar employees working in durable consumer goods industry in Türkiye. Results showed that workplace exclusion is positively related to intention to leave and negatively related to self-esteem. Self-esteem is negatively related to intention to leave. Additionally, it was found that self-esteem has not a mediation function. Self-esteem plays a significant role as a function of moderation between workplace exclusion and intention to leave. Practice of our findings and implications for the research are discussed in this study.
Drug repurposing: A futuristic approach in drug discovery
Authors: Khan Saba , Agnihotri Jaya , Patil Sunanda , Khan Nikhat
Published: July 2023

Drug repurposing (DR), also known as drug repositioning, is a strategy aimed at identifying new therapeutic uses for existing drugs. It offers an effective approach to discovering or developing drug molecules with novel pharmacological or therapeutic indications. In recent years, pharmaceutical companies have increasingly embraced the drug repurposing strategy in their drug discovery and development programs, leading to the identification of new biological targets. This strategy is highly efficient, time-saving, cost-effective, and carries a lower risk of failure compared to traditional drug discovery methods. By maximizing the therapeutic value of existing drugs, drug repurposing increases the likelihood of success. It serves as a valuable alternative to the lengthy, expensive, and resource-intensive process of finding new molecular entities (NMEs) through traditional or de novo drug discovery approaches. Drug repurposing combines activity-based or experimental methods with in silico-based or computational approaches to rationally develop or identify new uses for drug molecules. It leverages the existing safety data of drugs tested in humans and redirects their application based on valid target molecules. This approach holds great promise, particularly in addressing rare, difficult-to-treat diseases, and neglected diseases. By utilizing the wealth of knowledge and resources available, drug repurposing presents an emerging strategy for optimizing the therapeutic potential of existing medicines. It offers a pathway to rapidly identify effective treatments and repurpose approved drugs for new indications, benefiting patients and healthcare systems alike.
Does Maslow’s Hierarchy of Needs Explain Volunteer Time Allocations? An Exploration of Motivational Time Allowances Using the American Time Use Survey
Authors: Babula Michael , Muschert Glenn
Published: July 2023

This study examines whether there is an optimal set point along Maslow’s (1943) hierarchy of needs associated with disaggregated forms of volunteerism. Taniguchi’s (2012) study examined major life domains (e.g., work, education, and religion) for associations with formal and informal volunteerism. An alternative approach is to include life domains with variables measuring motivational concerns to better identify time allocation patterns for disaggregated volunteerism. This study analyzed the results of 9,435 time diaries recorded on the 2019 American Time Use Survey (ATUS). The time allocated to formal and informal volunteerism associates with intermediate belongingness concerns. There is no association between time spent on self-esteem and self-actualization concerns and informal volunteering. Tertiary education as a baseline measure for self-actualization shares a weaker association than belonging with formal volunteering. The data suggest that research into maximizing formal volunteerism may be searching at the wrong point at self-actualization. Implications are discussed for motivating volunteerism.
An Integrated Testbed for Power System Cyber-Physical Operations Training
Authors: Chamana Manohar , Bhatta Rabindra , Schmitt Konrad , Shrestha Rajendra , Bayne And Stephen
Published: July 2023

The increased adoption of information and communication technology for smart grid applications will require innovative cyber-physical system (CPS) testbeds to support research and education in the field. The groundbreaking CPS testbeds with realistic and scalable platforms have progressively gained interest in recent years, with electric power flowing in the physical layer and information flowing in the network layer. However, CPSs are critical infrastructures and not designed for testing or direct training, as any misbehaving in an actual system operation could cause a catastrophic impact on its operation. Based on that, it is not easy to efficiently train professionals in CPSs. Aiming to support the advancement and encourage the training of industry professionals, this paper proposes and develops a complete testbed with commercial tools. The testbed can reliably replicate the performance of smart grid systems and the main potential cyber threats that electric grids may face. The complex interdependencies between the cyber and physical domains are discussed in detail, and different case scenarios are presented, providing insightful guidelines for key features and design decisions for future smart grid testbeds.
Investigating the Motivational and Influencing Factors on Choosing Food Items by Citizens of Tabriz, Iran
Authors: Torabi Mahin , Monajjemzadeh Farnaz , Safavizadeh Vahid , Khodayari Mohammad Taghi , Nemati Mahboob
Published: July 2023

Background
Due to the prevalence of nutrition-related diseases, choosing the right food items for various age groups is necessary in modern societies. Those aspects related to characteristics, society, and culture are the main motivations for food choices. Understanding the determinants of food choices can help policymakers design better strategies to promote healthy food choices in the public. This study aimed to find appropriate nutritional factors and understand the motivation for food choices. We also investigated the factors affecting the purchase and consumption of food items among citizens of Tabriz, Iran.
Methods
In this cross-sectional descriptive study, 209 valid and reliable researcher-made questionnaires were randomly distributed among volunteer citizens of Tabriz. The obtained information was analyzed in various fields, such as nutritional information, food health, price, weight control, appearance and taste, natural ingredients, ease of cooking, ease of access, and popularity of the manufacturing plant.
Results
According to the demographic findings, most participants were female (61%). The average age of the participants was 36.53 ± 7 years, and most were married. The educational level of 60% of the individuals was above the master's degree, and the income of 32.5% was reported as 20–40 million IRR. Price, health, and ease of cooking were the strongest determining factors for food choices, and the feeling of cheerfulness was the least influential factor. Also, there was a significant relationship between “nutrition and health information with different education levels”, “information and weight control with different occupational groups”, and “information and price with participant's income”.
Conclusion
The researcher-made questionnaire used in this study had high validity. So, it can be used to determine the motivational and influencing factors in choosing food items in Iran.
Chronic inflammation does not mediate the effect of adiposity on grip strength: results from a multivariable Mendelian Randomization study
Authors: Norris Tom , Sanderson Eleanor , Cooper Rachel , Garfield Victoria , Pereira Snehal M Pinto
Published: July 2023

The relationship between adiposity and grip strength (GS) is complex. We investigated whether one pathway through which adiposity affects GS was via chronic inflammation. 367,583 UK Biobank participants had body mass index (BMI), waist-hip-ratio (WHR), C-reactive protein (CRP) and GS data. Univariable and multivariable Mendelian randomization (MR) analyses (inverse variance weighted (MR-IVW), MR-Egger) estimated total, direct and indirect effects of adiposity traits on GS using genetic instruments for BMI and WHR (exposures) and CRP (mediator). Observational findings suggested higher BMI was associated with stronger grip, e.g., in males, per standard deviation (SD) higher BMI, GS was higher by 0.48kg (95%CI:0.44,0.51), independent of CRP. For males MR estimates were directionally consistent; for females, estimates were consistent with the null. Observational findings for WHR suggested that higher WHR was associated with weaker grip. In multivariable MR-IVW analyses, effects in males were consistent with the null. In females, there were consistent effects, e.g., 1-SD higher WHR was associated with 1.25kg (MVMR-Egger; 95% CI:0.72,1.78) stronger grip, independent of CRP. Across sexes and adiposity indicators, CRP’s mediating role was minor. Greater adiposity may increase GS in early old age, but effects vary by sex and adiposity location. There was no evidence that inflammation mediated these effects.
Effect of ciprofol- and propofol-induced sedation for gastrointestinal endoscopy on pharyngeal swallowing function: A prospective experimental study
Authors: He Bin , Lv Shun , Liao Jinsong , Wang Xiong , Jiang Min , Song Wen , Zhang Qiuyu
Published: July 2023

Background Ciprofol and propofol are equally safe and effective in enabling patients to undergo painless gastroscopy. However, the effects of ciprofol on swallowing have not been reported. We aimed to compare the effects of ciprofol and propofol on pharyngeal swallowing function in patients undergoing gastrointestinal endoscopy. Methods We randomly divided 237 patients aged 22–64 years with American Society of Anesthesiologists class I–II undergoing gastrointestinal endoscopy into the ciprofol (Group C, n = 116) or propofol (Group P, n = 121) group. Patients in Group C and Group P received an intravenous bolus injection of 0.6 mg/kg ciprofol and 2.5 mg/kg propofol, respectively, with the injection time exceeding 30 s. Endoscopy was performed when the Modified Observer's Assessment of Alertness/Sedation score was ≤ 1. The primary outcome was the incidence of severe dysphagia. The Penetration and Aspiration Scale score, Dysphagia Severity Score, occurrence of laryngeal adductor reflex, and arytenoid joint laxity were recorded. The secondary outcomes included the time spent in the post-anesthesia care unit, postoperative recovery time, and incidence of gag reflex, body movement, respiratory depression, hypotension, and postoperative dizziness. Results Group C had a significantly higher incidence of the laryngeal adductor reflex than Group P (54.2% vs. 34.2%, < 0.05), while the incidence of severe dysphagia in Group C was lower than that in Group P (12.9% vs. 33.1%, P < 0.05). The incidence of body movements in Group C was lower than that in Group P (15.5% vs. 31.4%, P < 0.05). Conclusions Compared with propofol, ciprofol may be more beneficial in retaining partial pharyngeal swallowing function to reduce body movements and the risk of aspiration; however, the mechanism requires further investigation. Trial registration: This trial was registered with the China Clinical Trials Centre (Registration Number: ChiCTR2100054446, registration date: 17/12/2021).
Seasonal study on the Aquatic and Terrestrial Habitat of Edayar region, Ernakulam, Kerala, India
Authors: Syamlal Chandni Asha , Sayantan D.
Published: July 2023

This study examines the plant diversity and physicochemical characteristics of both aquatic and terrestrial ecosystems in the industrialized region of Edayar, Kadungalloor, Ernakulam, Kerala, India. The research is conducted seasonally, encompassing the four seasons of Kerala: southwest monsoon, northeast monsoon, winter season, and summer season. Edayar is home to approximately 400 industries. The main objective of this study is to assess the plant diversity, with a specific focus on herb and macrophyte diversity, in the Edayar region, along with analyzing the physicochemical properties of soil and water. Random sampling using quadrat techniques is employed to collect data on species diversity. Diversity indices, such as the Simpson Index and Shannon-Wiener Index, are utilized to analyze the recorded species diversity. Scoparia dulcis L. among herb species and Eichhornia crassipes (Mart.) Solms among macrophytes were found dominating in all the seasons. The results for the physico-chemical analysis of water and soil were found approaching to the threshold of standard limits.The findings provide valuable insights into plant diversity and ecological dynamics of the Edayar region, which have been significantly impacted by industrial activities. The outcomes serve as a basis for the development and implementation of effective conservation and management strategies to mitigate potential ecological risks associated with industrial activities in the region.
The impact of care coordination for children with medically complex cerebral palsy: a protocol for a multiple methods study
Authors: Harvey Adrienne , Shepherd Daisy , Gibb Susan , D'Aprano Anita , Babic Rose , Hunter Frances , Jealous Gretta , Carter Rob , Reddihough Dinah , Baikie Gordon , Imms Christine
Published: July 2023

Background: Children with medically complex cerebral palsy have severe functional limitations and multiple medical comorbidities requiring frequent hospital appointments and admissions and input from many clinical specialties over the course of each year. Complex care programs, which coordinate care for children with medical complexity, are growing in number internationally, however there is little evidence to guide their design and implementation, particularly in the Australian health care setting. This paper reports on a protocol for a study that will explore: 1) the impact of receiving support from a complex care service on service utilisation and costs, and 2) the experiences and perspectives of caregivers of children with medically complex cerebral palsy and health care professionals involved in the care of these children. Information obtained will be used to co-design improved care pathways to optimise access, experiences and outcomes of health services for this vulnerable group.
Methods: This study will use a multiple-methods, three-phase, observational design through an integrated knowledge translation approach. Phase 1 will examine: 1) existing quantitative data regarding in- and out-patient hospital service utilisation, and 2) health, disability and socio-demographic characteristics of children with medically complex cerebral palsy, and their families. Phase 2 will: 1) use qualitative methods to explore the perceptions, experiences and cost impacts from family and the service provider perspectives, and 2) synthesise evidence for an outcome framework through a systematic review. Phase 3 will use information gained to co-design (with parents, clinicians and researchers) the crucial components of care-processes and methods for evaluating care outcomes, that can be embedded and tested within the clinical setting, including cost-effectiveness.
Discussion: This co-designed multiple-methods study aims to enhance outcomes for children with medically complex cerebral palsy and their families. The results will influence the way healthcare services are delivered to this population locally, with transferability to other healthcare services nationally and internationally. Findings will contribute to the limited evidence currently available and therefore provide much needed guidance for service providers to optimise the way healthcare is delivered to this vulnerable and complex population of children.
Trial Registration: This trial is registered with the Australian New Zealand Clinical Trials
Registry. (ACTRN12622000678796p).
Temperature-dependent phase composition and mechanical properties of heat-treated nickel-titanium rotary endodontic instruments at room and body temperatures
Authors: Kasuga Yuka , Kimura Shunsuke , Maki Keiichiro , Unno Hayate , Omori Satoshi , Hirano Keiko , Ebihara Arata , Okiji Takashi
Published: July 2023

Background The aim of this study was to evaluate the phase composition, phase transformation temperatures, bending property, and cyclic fatigue resistance of differently heat-treated nickel-titanium (NiTi) rotary instruments with the same tip diameter and taper at room (RT; 25 ± 1 °C) and body (BT; 37 ± 1 °C) temperatures. Methods Five heat-treated NiTi rotary instruments, HyFlex EDM (EDM), HyFlex CM (CM), Vortex Blue (VB), RE file CT (RE) and JIZAI, and a non-heat-treated NiTi rotary instrument (Mtwo) with a size 40, 0.04 taper were investigated. Temperature-dependent phase transformation was examined with differential scanning calorimetry (DSC). The bending loads of the instruments at RT and BT were evaluated using a cantilever-bending test. Cyclic fatigue resistance at RT and BT was measured using a dynamic test, during which the instruments were rotated in combination with a 2-mm back-and-forth motion in an artificial curved canal, and the number of cycles to failure (NCF) was determined. The results were analyzed using two-way repeated measures analysis of variance, a simple main effect test, and the Bonferroni test (α = 0.05). Results DSC results indicated that EDM and Mtwo were primarily composed of martensite/R-phase and austenite, respectively, while the other heat-treated instruments were composed of a mix of martensite/R-phase and austenite at the tested temperatures. Regardless of the temperature setting, the bending loads of heat-treated instruments were significantly lower than those of Mtwo (p < 0.05). EDM showed the lowest bending loads and highest NCF at both temperatures (p < 0.05). CM, VB, and JIZAI showed significantly higher bending loads at BT than at RT (p < 0.05). The NCF of all the heat-treated instruments, except VB, was lower at BT than at RT (p < 0.05). At BT, the NCF of CM, RE, and JIZAI were not significantly higher than that of Mtwo (p > 0.05). Conclusions Heat-treated NiTi instruments exhibited lower bending loads and higher NCF values than Mtwo. However, this tendency was less pronounced at BT than at RT, particularly in instruments composed of a mix of martensite/R-phase and austenite.
Educational attainment, severity, and prognosis of intracerebral hemorrhage
Authors: Yechoor Nirupama , Rist Pamela , Ganbold Alena S , Kourkoulis Christina , Mora Samantha , Mayerhofer Ernst , Parodi Livia , Rosenfeld Lindsay , Anderson Christopher D. , Rosand Jonathan
Published: July 2023

Background and Objectives:
Despite advances in acute stroke management, the prevalence and incidence of intracerebral hemorrhage (ICH) are increasing, warranting study beyond biological and clinical determinants to improve primary and secondary prevention. Educational attainment is a critical social determinant of health that impacts risk of all-cause mortality, acute cardiovascular events, as well as severity of incident ischemic stroke, but less is known of its impact on ICH. The objective of this study is to determine whether educational attainment is associated with ICH severity and prognosis.
Methods
Subjects were enrolled in a prospectively ascertained cohort of patients with primary ICH from 1994 until 2020 at the Massachusetts General Hospital Neurosciences Intensive Care Unit. Educational attainment, medical history of ICH risk factors, ICH volume, and ICH score were obtained on admission. The primary outcomes were ICH volume and the ICH score.
Results
Of 2,539 patients eligible for analysis, the median age of the sample was 74 (IQR 64–82) and 2,159 (85%) had high school only education, including diplomates and those with some high school education. 1655 (65%) presented with an ICH volume less than or equal to 30mL and 1,744 (69%) presented with an ICH score less than 30. In multivariable logistic regression analyses controlling for age, income bracket, employment history, and pre-stroke diagnoses of hypertension and coronary artery disease, patients with high school-only education were more likely to have an ICH volume greater than 30mL compared to college diplomates (odds ratio 1.61, 95% 1.24, 2.08) and also more likely to have an ICH score of 3 or greater compared to college diplomates (odds ratio 2.37, 95% CI 1.77, 3.19).
Discussion
Pre-stroke educational attainment carries an independent association with ICH severity and prognosis, with lower educational attainment associated with larger ICH volumes and higher ICH scores. These results suggest that primary and secondary prevention strategies should consider the important social determinant of educational attainment as an independent risk factor for ICH, in addition to traditional clinical risk factors. Future studies are needed to examine how educational attainment impacts exposures to traditional clinical risk factors, healthcare access, and health-related behaviors.
Modeling and parametric performance analysis of Field Emission Electric Propulsion
Authors: Gadisa Dinaol , Bang Hyochoong
Published: July 2023

This article provides an overview of parametric performance analysis of field emission electric propulsion. The change in thrust of the thruster over time and over applied voltage was analyzed utilizing various types of propellant, and assuming the fuel mass is equal to the atomic mass of the propellant , wet mass of the spacecraft is assumed to be 6kg, and the charge of an ion is assumed to be 1.602 × 10 −19 while the applied voltage is up to 10 kV. The simulation results show that the thrust value of the FEEP thruster over time ranges from 0.213µN to 211mN during stable ion flow rate and mass expulsion of indium propellant, implying that the result is comparable to realistic FEEP parameters. Furthermore, as expected, increasing the voltage between emitter and extractor electrodes and decreasing the mass expulsion of the propellant increased the thrust value of the FEEP thruster.
Protective effects of epigallocatechin-3-gallate against ultraviolet radiation caused keratinocyte injury: targeting the NLRP3 inflammasome priming and activation
Authors: Luo Zhu-Lin , Zhang Qi-Xiong , Du Min , Wang Qian , Liu Yi , Ren Jian-Dong
Published: July 2023

Inflammatory response occurring after ultraviolet (UV) exposure is regarded as one of the major causes of skin photodamage. As a crucial mediator of inflammatory cascades, the NOD-like receptor protein 3 (NLRP3) inflammasome has been reported to be responsible for UV radiation (UVR) evoked inflammation in keratinocytes, emerging as a promising target for therapeutic intervention. Epigallocatechin-3-gallate (EGCG), the most abundant polyphenol in green tea, has been found to afford protection against UVR-caused keratinocyte injury, but mechanism clarifying its precise target still awaits further exploration. The aim of this study was to examine whether EGCG had the ability to inhibit UVR-triggered NLRP3 inflammasome activation in keratinocytes which accounted for the protection against cell damage. The results showed EGCG prevented HaCaT cells from UVR-induced DNA insults by counteracting oxidative stress and inflammatory cytokines production. NLRP3 inflammasome activation in response to UVR was markedly suppressed by EGCG. Moreover, EGCG inhibited the induction of new mtDNA synthesis by downregulating the expression of IRF-1, CMPK2 and phosphorylated STAT1. Meanwhile, EGCG reduced the excessive production of mitochondrial reactive oxygen species (mtROS) and ox-mtDNA in UV-exposed cells so that both deubiquitination of NLRP3 and the binding of ox-mtDNA to NLRP3 were suppressed, resulting in impaired NLRP3 inflammasome priming and activation. Our results have identified the potent activity of EGCG to ameliorate NLRP3 inflammasome-driven photodamage in keratinocytes caused by UVR. Apart from the mtROS-scavenging activity which enabled EGCG to antagonize mtROS-triggered NLRP3 inflammasome activation, a novel antioxidation-independent mechanism of EGCG in NLRP3 inhibition was revealed.
Automated high-content image-based characterization of microorganism behavioral diversity and distribution
Authors: Lupatelli Carlotta Aurora , Attard Agnès , Kuhn Marie-Line , Cohen Celine , Thomen Philippe , Noblin Xavier , Galiana Eric
Published: July 2023

Background Microorganisms evolved complex systems to respond to environmental signals. Gradients of particular molecules alter microbe behavior and distribution within their environment. Microdevice tools coupled to automated image-based methods are now employed to analyze instantaneous distribution and motion behaviors of microbial species in controlled environments at small temporal scales, mimicking to some extent macro conditions. Such technologies have already been adopted for investigations mainly on individual species. Similar versatile approaches must now be developed for the characterization of multiple and complex interactions between the microbial community and environment.
Results Here, we provide a comprehensive step-by-step method for the characterization of species-specific behavior of a synthetic mixed microbial suspension in response to an environmental driver. By coupling accessible microfluidic devices with automated image analysis approaches, we evaluated the behavior response of three morphologically different telluric species (Phytophthora parasitica, Vorticella microstoma, Enterobacter aerogenes) to a potassium gradient driver. Using the TrackMate plug-in algorithms, we performed morphometric and then motion analysis to characterize each microbial species response to the driver. Such approach enabled us to confirm the different shape features of the three species, and to simultaneously characterize their particular motion adaptation to the driver, as well as their co-interaction dynamics.
Conclusions The results obtained demonstrated the feasibility of the method to screen mixed-species suspension dynamics at high spatial and temporal scale. By increasing the complexity of suspensions, this approach could be integrated to support conventional omics methods, contributing to characterizing how the main drivers operate at the microbiota-host-environment interfaces. In its current advances, the method can integrate screening strategy, for example, for biocontrol agent evaluation, enlightening possible beneficial-pathogenic interactions based on co-colonization of micro habitats.
Shotgun Metagenomics Unravels the Bacterial Diversity, Resistome Profile and Genetic Exchange in a Tropical Urban Environment
Authors: Nimaichand Salam , Philip Jamiema Sara , Prasad Roshny , Nori Sai Ravi Chandra , Divakaran Soumya Jaya , Ramaraj Subakamakshi Krishnawami , John Jiffy , Chereddy Padma , Patel Neha P , Nelson-Sathi Shijulal
Published: July 2023

Background
The environmental microbiome has a direct influence on human health and disease. Previous reports suggest that urbanization and anthropogenic activities can alter natural microbial flora and potentially spread infectious disease-causing agents by emergence of pathogenic strains of bacteria. The nature of microbes present in urban settings and the flow of genetic elements between environmental and clinically relevant pathogenic bacteria, however, remains largely unknown.
Results
To unravel the bacterial diversity and resistome profile of multiple hotspot setups of a tropical urban system such as transport hubs, wet markets, hospital surroundings, waste dumps, and urban coastal area (beaches) metagenomics analyses of sediment samples from around Thiruvananthapuram city were done. Our study revealed the presence of 3,735 species belonging to 46 phyla of bacteria and archaea. The phylum Pseudomonadota was the most abundant bacterial community, followed by Bacteriodota and Actinomycetota. The genus Cloacibacterium had the highest overall relative abundance, while Pseudomonas was the most prevalent bacterial genus in hospital surroundings and coastal area (beaches) settings. We identified 291 antimicrobial resistance genes (ARGs) in the urban resistome, conferring resistance to more than 15 drug classes. The hospital settings had the highest number of ARGs across different drug classes. From the culturomics microcosm setups, we reconstructed 62 high-quality metagenome-assembled genomes (MAGs) which shows high resemblance to pathogenic bacterias such as Klebsiella pneumoniae, Escherichia coli and Acinetobacter baumannii etc. The ARGs detected in these genomes include genes encoding antibiotic-modifying enzymes (ArnT, eptA, eptB), beta-lactamase (ampC, ampC1, ampH), transcription regulating proteins (KpnE, KpnF, KpnG), efflux pumps (oqxA, oqxB). Furthermore, eight MAGS belonging to Acinetobacter kookii, Acinetobacter pitti, Acinetobacter baumannii, Acinetobacter gerneri, Escherichia coli, Klebsiella pneumoniae and Klebsiella quasipneumoniae were found to contain virulence factors such as siderophores (acinetobactin, aerobactin, enterobactin etc.), capsule, secretion systems belonging to type III group) (T3SS, TTSS etc) or type II (T2SS), fimbriae (type 3 and I), efflux pump (AdeFGH), or quorum sensing (abaR) associated with pathogenicity.
Conclusions
The study provides insights into bacterial composition, antimicrobial resistance, and virulence potential in urban environments, highlighting the importance of monitoring and managing antimicrobial resistance in urban ecosystems.
Thermal threshold for localized Blood-Brain-Barrier disruption
Authors: Bär Sébastien , Buchholz Oliver , Münkel Christian , Schlett Paul , Levan Pierre , von Elverfeldt Dominik , Hofmann Ulrich
Published: July 2023

The Blood-Brain Barrier is the gatekeeper of the CNS. It effectively shields the brain from blood-borne harm but simultaneously represents a significant challenge for treating neurological diseases. Altering its permeability enables increasing the local drug concentration and thereby improving the therapeutic effect. Although permeability increase is achieved by raised tissue temperature, the determination of the thermal dosage suffers from imprecise thermometry during hyperthermia application. Knowledge of the thermal dosage is crucial for improving hyperthermia related interventions of the CNS. Here we show an approach to determine the thermal threshold for localized Blood-Brain Barrier disruption estimated by MR thermometry. Using an IR laser (λ = 1470nm) we showed that highly localized Blood-Brain-Barrier opening can be achieved with mild to moderate hyperthermia. Non-invasive MR thermometry has been used to determine the temperature at the heating site. Blood-Brain Barrier opening has been monitored by DCE-MRIin vivoand post mortem via Evan’s Blue extravasation. The Blood-Brain-Barrier permeability can be altered locally with minimal thermal dosages. Thus mild hyperthermia represents a promising approach to making the brain accessible for therapeutic interventions.
Podmioty gospodarcze wytwarzające energię odnawialną w województwie zachodniopomorskim
Authors: Błażejowska Małgorzata
Published: July 2023

W artykule dokonano analizy prawnych form podmiotów posiadających koncesję na wytwarzanie energii elektrycznej na przykładzie woj. zachodniopomorskiego na podstawie danych Urzędu Regulacji Energetyki, Krajowego Rejestru Sądowego i Centralnej Ewidencji i Informacji o Działalności Gospodarczej. Opracowanie zawiera zwięzłą charakterystykę oraz przedstawia wady i zalety poszczególnych rodzajów działalności. W woj. zachodniopomorskim dominują elektrownie wodne (46%), których właścicielami są głównie osoby fizyczne prowadzące działalność gospodarczą i spółki cywilne. Podmioty te stanowią łącznie aż 62% przedsiębiorstw koncesjonowanych. Jednakże na skutek obecnego ustawodawstwa ich rozwój jest zahamowany. W ostatnich latach powstają głównie spółki z ograniczoną odpowiedzialnością – samorządowe lub z udziałem kapitału zagranicznego prowadzące elektrownie wiatrowe lub biogazowe.
Quality Attribute-Price Relationship: Modernization of the Sweet Cherry Sector in Poland
Authors: Florkowski Wojciech , Łysiak Grzegorz
Published: July 2023

This study describes the development of sweet cherry production in Poland in the context of relationship between quality attributes and wholesale prices as well as modernization of orchards creating opportunities for increased exports. Global demand for sweet cherries increases because of their perceived unique health benefits, but the fruit must have the desired quality attributes. The link between quality attributes and prices is illustrated using the wholesale prices collected during the harvest season in years of limited and normal crop in Poland, respectively. Among the discussed varieties is ‘Cordia’ which dominates in the modern orchards. As the sweet cherry production declines in the region, with the introduction of modern production technology, the increasing yields and volume produced creates opportunities for increased exports also to countries outside the EU.
Effect of nano-silica extracted from two different plant sources on survival and development of Phthorimaea opercullela (Zeller) larvae
Authors: Idris I. , Naddaf M. , Harmalani H. , Alshater R. , Alsafadi R.
Published: July 2023

The study examined the effect of nano-silica extracted from two different plant sources on the survival and development of the potato tuber moth, Phthorimaea opercullela. The silica powder was derived from two different agricultural byproducts, olive stones and corncobs. Characterization by X-ray diffraction revealed that the extracted powder has an amorphous silica phase. The nitrogen adsorption-desorption measurements revealed that both extracted and treated silica have mesoporous structure, with a specific surface area of around 300 m2/g and 270 m2/g for the silica derived from olive stones and corncobs, respectively. The silica nanoparticles (SiO2 NPs) prepared from the silica derived from olive stοnes showed higher larvae mortality, pupae weight, and larval and pupal developmental time, compared to the silica derived from corncombs. The results show that the nano-silica derived from agriculture byproducts can be as effective as the synthetic insecticide (deltamethrin) utilized in control of the potato tuber moth, with lower environmental impact in terms of preventing pesticide residue accumulation. In addition, the efficiency of SiO2 NPs applications depends on the source of the silica nanoparticles and the applied concentration to achieve the optimum results for the pest control.
ANALYSIS OF FACTORS AFFECTING DETECTability OF DEFECTS IN Railroad RAILS under ULTRASONIC TESTING
Authors: Бобров А.Л. , Гончаров К.И.
Published: July 2023

Надежность эксплуатации железнодорожного пути зависит от технического состояния рельсового полотна, которое, в свою очередь, подвергается периодическому контролю неразрушающему контролю, в котором ультразвуковые методы играют решающую роль. Работа посвящена исследованию температурного фактора на изменение основных параметров ультразвукового контроля рельсов, находящихся в эксплуатации. В статье приведены результаты теоретических и экспериментальных исследований изменений чувствительности каналов контроля рельсов наклонными преобразователями, связанных с изменением температурного фактора и колебаний угла ввода ультразвуковой волны при реализации типовых схем контроля. Контроль проводили ультразвуковым дефектоскопом и набором наклонных преобразователей с углами ввода 50…70°. Приведена методика проведения исследований и основные результаты, которые показывают, что на чувствительность контроля влияет температура, которая как погодный фактор может, таким образом, приводить к появлению ошибок первого и второго рода. Кроме того, исследована чувствительность к реальным дефектам рельсов – усталостным трещинам. По результатам исследований установлено, что при проведении ультразвукового контроля необходимо корректировать чувствительность контроля в зависимости от погодных условий, а также использовать гибкий механизм анализа результатов и повторного контроля.

The reliability of railway depends on the technical condition of the rail bed, which, in turn, is subjected to periodic control of non-destructive testing. Ultrasonic methods control has importance for railway traffic safety. This work is devoted to the study of the temperature factor on the change in the main parameters of the ultrasonic testing of railroad rails. The article presents the experimental results of changes in the sensitivity of the channels for monitoring rails by inclined probes, associated with a change in the temperature factor and fluctuations in the angle of probe of an ultrasonic wave during the implementation of typical control schemes. The control was carried out with an ultrasonic flaw detector and a set of inclined with angle probes in the range 50…70°. In article presented methodology and the main results, which show that the sensitivity of control is affected by temperature. It’s connected with weather factor, can thus lead to errors of the first and second kind. In addition, the sensitivity to real rail defects - fatigue cracks. The main result of the research is that during ultrasonic testing, it is necessary to adjust the sensitivity of the control depending on weather conditions and as well as use a flexible mechanism for analyzing the results and re-control.
Factors Affecting Online Accounting Education in Terms of The Technology Acceptance Model and Social Capital Theory: The Case of Türkiye
Authors: BELLER DİKMEN Beyhan , ÖZÇELİK Musa , DERAN Ali
Published: July 2023

With the developing technology and COVID-19 pandemic, certain changes have been made in various areas. One of these changes has emerged in education as the transformation of conventional learning systems into online learning systems. The online learning system is effective if both teaching staff and students are prepared in terms of presenting information content and assessing student performance. Otherwise, certain problems may be encountered throughout the adaptation process. Therefore, it is crucial to determine the factors affecting the utilization of online learning systems. The present study aims to find out the factors influencing the utilization of online learning systems by accounting students enrolled in both state and foundation universities in Türkiye during the COVID-19 pandemic. To this end, a survey questionnaire method was employed and survey questionnaire data were analyzed using SPSS and SmartPLS software. The analysis results revealed that social trust had an impact on perceived ease of use and perceived usefulness, perceived ease of use had an impact on perceived usefulness, and subjective norms had an impact on perceived usefulness; whereas perceived ease of use, perceived usefulness, and subjective norms were predictors of behavioral intention to use, and actual use was also affected by behavioral intention to use.
MODERN FINANCIAL TECHNOLOGIES OF INTRODUCING DIGITALIZATION INTO THE FINANCIAL SYSTEM
Authors: Baiguzina Luza
Published: July 2023

Introduction. Many researchers studying the causes of the economic crisis and its consequences, come to the conclusion that this process is bifurcational, in other words, it gives rise to the transition of the economic system to a new stage. The use of a "synergistic approach", in which the object or phenomenon under study is considered as a kind of "evolutionary process", when studying the patterns of functioning of the financial system in the Russian Federation, seems to be the most promising. This approach allows us to describe the operation of the financial and banking systems at the level of the entire state, which certainly allows us to develop and apply modern high-tech products and services created as a result of the digitalization of the financial system at the level of all subjects of the Russian Federation. Methodology. Research methods, such as statistical, analytical, observation and grouping methods, are aimed at identifying objects of digital technology transformation, the use of products and services in the financial system. When solving the problem of predicting the properties of the "digital economy" object, it is important to track the dynamics of the studied indicators. The analysis of large arrays of data gives a large number of analytical studies, the description of which allows us to build a predictive model of strategic development and demand behavior. Results. It has been determined that digitalization in the financial environment is necessary in terms of the transfer of products, services that should be available to the public, organizations, enterprises, be comfortable, and most importantly, aimed at obtaining financial services through a provider, through remote access. Conclusion. The key trends in the development of the financial market in our country, identified by the Central Bank of Russia, create conditions for increasing the efficiency, manufacturability and customer focus of market players.