bluuebunny/crossref_metadata_2025 huggingface dataset:
Associations Between Self-Reported Behavioral and Learning Concerns and DMD Isoforms in Duchenne Muscular Dystrophy
Authors: Counterman Kevin J. , Fatovic Kathy , Good Daniel C. , Martin Ann S. , Dasgupta Sonali , Anziska Yaacov
Published: October 2022

Background:

Duchenne muscular dystrophy (DMD) is an X-linked recessive neuromuscular disorder resulting from loss of dystrophin. In addition to its role in muscle, isoforms of dystrophin are expressed in different cell types of the brain, and DMD has been linked to language delays, behavioral abnormalities and learning disabilities.

Objective:

To determine whether disruption of specific DMD isoforms, age, corticosteroid use, ambulation status, or country are associated with behavioral and/or learning concerns in DMD.

Methods:

De-identified data were collected from the Duchenne Registry from 2007–2019. Females, patients with BMD, and those without genetic testing reports were excluded from the cohort. For the genetic analysis, patients were divided into four subgroups based on the location of their mutation and the predicted isoforms affected. Bivariate analysis was conducted using chi-square for categorical variables. Two multivariate logistic regressions were used to assess independent associations with behavioral and learning concerns, respectively, and to estimate the effect size of each variable.

Results:

DMD mutations disrupting expression of Dp140 and Dp71 were associated with a higher likelihood of reported behavioral and learning concerns. Corticosteroid use, categorical age, and country were other factors associated with behavior and learning concerns.

Conclusion:

This data adds to our current understanding of DMD isoforms, their mutational consequence and impact on behavior and learning.
A Case Study on Community-Driven Regional Development - Focusing on the Case of Lenok Village -
Authors:   The Korean Association For Local Administration, Lee Youngkyu , Bae Suho
Published: October 2022

The purpose of this study is to explore the potentiality of community-driven development through case study. The case selected in this study is Lenok Village in Hongcheon-gun, Gangwon-do, which is alienated from public services due to its geographical isolation and is regulated for regional development by environment-related laws. Community-driven development in Lenok Village began from resolving the inconvenience caused by the absence of village common facilities. Along with obtaining public funding projects from government ministries, consensus among members about the identity of the community, as suggested by Merchant (2010), has appeared. Through these efforts, Lenok Village has improved the core elements of social capital and has continuously improved economic, cultural and social services.
The implications from the case of Lenok Village are suggested as follows. First, the formation and agreement of community identity in community development allows a community to adhere to clear goals and directions, thus leading to consistent and voluntary participation. Second, the composition of village organizations, such as closed network proposed by Coleman(1988), becomes the basis for opinions and participation among various organizations in decision-making and participation, thereby resulting in securing transparency, openness, mutual monitoring and expectations, and easing conflicts in advance. Third, social harmony and solidarity among community members can be strengthened only when not only economic but also social and cultural aspects are secured in community-driven development.
Comparative Study on Long-term Care Insurance for the Elderly in Korea and Japan - focused on local government -
Authors:   The Korean Association For Local Administration, Park Kwang-Duck
Published: October 2022

Japan is the best case study of a low-fertility and aged society in Korea, and the fundamental purpose of this study is to find clues in Japan to overcome Korea's low-fertility and aged society. Therefore, the researcher evaluates and analyzes the various social policy that Japan has taken for the aging society, and intends to find our social welfare policy for the elderly from there. In the analysis, the researcher basically stood in the position of new institutionalism, identified the policy's historicity, path dependency, and value orientation. Gilbert and Terrel used more practical for using spectrum not dichotomy. Their policy analysis breaks away from the dichotomous approach of the existing universalist value and the selective approach, and places selectivism and universalism as two extremes so that they can analyze more realistic aspects, and set their position on one spectrum. Research also use this analysis tool because It is a very realistic policy analysis method to analyze whether between two counties, Korea and Japan are differenciated with each other or not. Researcher intends to reveal the characteristics of the welfare states of Korea and Japan. The analysis includes selection of values for policy making, and the policies used in the analysis include not only long-term care insurance (LTC) but also social services for the elderly for a low-fertility and aging society. Through the analysis so far, the researcher confirmed the fact that Korea and Japan, which belong to the same type of welfare state, especially Long-term care insurance and social services for the elderly between the two countries. They are clearly divided into more selective perspectives in Korea and more universalistic perspectives in Japan. Finally, I would like to conclude by suggesting and writing about the establishment of a regional integrated care system that Japan is promoting as a measure for a low-fertility and aging society.
The use of lupine flour in baking
Authors:   Russian State Agrarian University – Moscow State Agricultural Academy named after K. A. Timiryazev, Begeulov M. Sh. , Konorev P. M. ,   Russian State Agrarian University – Moscow State Agricultural Academy named after K. A. Timiryazev
Published: October 2022

The results of a study of the possibility of using lupine flour produced from the seeds of the narrow-leaved lupine variety Deco 2 in the production of bakery products are presented. The possibility of using lupine flour in the amount of 5 % by weight of premium wheat flour has been established in order to improve the physicochemical and organoleptic indicators of bakery products. The possibility of adding 10–15 % lupine flour to enrich bread with biologically valuable nutrients without a noticeable deterioration in the quality of finished products is shown.
PENGARUH DER (DEBT TO EQUITY RATIO), PROFITABILITAS DAN KEPEMILIKAN MANAJERIAL TERHADAP NILAI PERUSAHAAN PADA PERUSAHAAN MAKANAN DAN MINUMAN YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2016-2020
Authors: Sulastiningsih Sulastiningsih , Khanifa Annasya Isna , Setyowati Hasanah
Published: October 2022

Penelitian ini bertujuan untuk mengetahui hasil pengaruh DER (Debt to Equity Ratio), Profitabilitas, dan Kepemilikan Manajerial terhadap nilai perusahaan makanan dan minuman yang terdaftar di Bursa Efek Indonesia (BEI) selama periode 2016-2020, baik secara parsial maupun simultan. Variabel yang diteliti yaitu : DER (Debt to Equity Ratio), Profitabilitas (ROA), dan Kepemilikan Manajerial dan nilai perusahaan yang diproksikan dengan nilai Price Book Value (PBV). Populasi dalam penelitian ini adalah perusahaan makanan dan minuman yang terdaftar di Bursa Efek Indonesia (BEI) pada tahun 2016-2020. Sampel dalam penelitian ini sebanyak 7 perusahaan makanan dan minuman yang diperoleh dengan teknik purposive sampling. Metode analisis yang digunakan dalam penelitian ini adalah analisis regresi linier berganda.

Hasil dari penelitian dengan menggunakan analisis regresi linier berganda menunjukkan bahwa secara parsial DER (Debt to Equity Ratio) dan Profitabilitas tidak berpengaruh terhadap nilai perusahaan sedangkan Kepemilikan Manajerial berpengaruh signifikan terhadap nilai perusahaan. Hasil dari perhitungan secara simultan (bersama-sama) menunjukkan bahwa variabel DER (Debt to Equity Ratio), Profitabilitas, dan Kepemilikan Manajerial berpengaruh signifikan terhadap nilai perusahaan makanan dan minuman yang terdaftar di Bursa Efek Indonesia (BEI) periode 2016-2020.
PENGARUH KEMASAN DAN KUALITAS PRODUK TERHADAP KEPUTUSAN PEMBELIAN WARDAH
Authors: Hadipranata Qurrata Ayunina Ciptantri , Sumardi Renanda Pradina
Published: October 2022

Penelitian ini bertujuan untuk mengetahui pengaruh kemasan dan kualitas produk terhadap keputusan pembelian pada konsumen Wardah di Mutiara Cosmetics Yogyakarta. Populasi dalam penelitian ini adalah konsumen Wardah yang pernah melakukan pembelian di Mutiara Cosmetics Yogyakarta yang berjumlah 100 orang. Sampel yang digunakan dalam penelitian adalah seluruh responden yang bejumlah 100 orang. Instrumen penelitian ini berupa kuesioner yang telah diuji validitas dan reliabilitasnya. Teknik analisis data menggunakan regresi berganda.

Hasil penelitian menunjukkan bahwa: (1) kemasan berpengaruh positif terhadap keputusan pembelian konsumen Wardah di Mutiara Cosmetics Yogyakarta, yaitu nilai t hitung = 4.370; nilai signifikansi 0,000<0,05; dan koefisien regresi = 0,406. (2) kualitas produk berpengaruh positif terhadap keputusan pembelian konsumen Wardah di Mutiara Cosmetics Yogyakarta, yaitu nilai t hitung = 3.841; nilai signifikansi 0,000<0,05; dan koefisien regresi = 0,375. (3) kemasan dan kualitas produk berpengaruh secara bersama-sama terhadap keputusan pembelian konsumen Wardah di Mutiara Cosmetics Yogyakarta, yaitu nilai F hitung = 47.673 dengan signifikansi 0,000<0,05.
ОСОБЛИВОСТІ ПЕРЕБІГУ, ДІАГНОСТИКИ ТА ЛІКУВАННЯ ЗА УРОЛІТІАЗУ У СОБАК
Authors: Самойлюк Вячеслав Володимирович , Білий Дмитро Дмитрович , Масліков Сергій Миколайович , Вакулик Вячеслав Володимирович
Published: October 2022

Моніторинговими дослідженнями визначали поширеність, вікові, статеві та сезонні особливості перебігу уролітіазу собак в умовах мегаполісу, ретельно аналізували раціон хворих тварин; проводили мікроскопію осаду сечі, рентгенологічні та сонографічні дослідження. В досліді до комплексу лікування собак хворих на уролітіаз крім Цефтриаксону, Но-Шпи та Фітоеліти вводили препарати антигомотоксичної дії (Мукоза Композитум, Траумель Композитум) та Дексаметазон. За відсутності лікувального ефекту виконували цистотомію з видаленням уролітів. З конкрементів частіше зустрічалися оксалати та урати. Під час диференціальної діагностики й контролю якості лікувальних заходів в дослідній і контрольній групах проводили рентгенологічне і сонографічне дослідження. Відмічена висока ефективність цих візуальних методів за сечокам’яної хвороби. На уролітіаз частіше хворіли собаки з зайвою вагою у віці з 1 до 10 років. В більшості випадків хворобу реєстрували у дрібних порід, особливо пекінесів, кокеспанієлів та йоркширських тер’єрів. Захворюваність на сечокам’яну хворобу майже рівномірно реєструвалася протягом року і була дещо вищою у весняний та осінній періоди. Лікування тварин дослідної групи було ефективнішим, дозволяло скоріше зняти запалення і забезпечити кращу регенерацію слизових оболонок сечовивідних шляхів, що було підтверджено результатами лабораторних і ультразвукового досліджень. Встановлено, що шляхом проведення візуальної діагностики можна з високою вірогідністю дати оцінку стану органів сечовивідної системи, виявити конкременти, визначити їх розмір та локалізацію з метою призначення ефективного консервативного, оперативного або комплексного лікування. Рентгенологічні та сонографічні дослідження сечової системи дозволяють ефективно контролювати динаміку ефективності лікувальних заходів, а за необхідності, вносити корективи до терапевтичного впливу на організм тварини. Важливе значення під час диференціальної діагностики має також мікроскопія осаду сечі, що є доступним, інформативним та недорогим методом. Під час комплексного лікування собак хворих на уролітіаз рекомендуємо долучати гомеопатичні препарати і глюкокортикоїди, а за наявності в сечовому міхурі великих або нерозчинних конкрементів виконувати циcтотомію.
Territorio lacustre: motivaciones y rendimiento deportivo de los canoístas adolescentes
Authors:   niversidad de Guadalajara, Sandoval Contreras Rigoberto , Cortés Farías Luis Daniel ,   Instituto de Estudios Superiores de Petatzécuaro
Published: October 2022

El objetivo es conocer las motivaciones y el rendimiento deportivo de los canoístas adolescentes que viven en la isla de Urandén de Morelos, del municipio de Pátzcuaro, en el estado de Michoacán, el cual es un territorio rural delimitado y rodeado de agua. Durante un año y medio se hicieron observaciones de campo para saber cómo viven estos y cuáles son las actividades que realizan en la vida cotidiana. Se realizaron entrevistas formales e informales y se conoció el entrenamiento que reciben los adolescentes deportistas. Como se podrá ver, la motivación y el rendimiento son determinados por variables económicas y familiares, por el entretejido de relaciones sociales que se establecen en el tiempo y el territorio comunitario, así por intereses de cada uno. El apoyo moral y motivacional de la familia parece ser fundamental, pues estos jóvenes son de escasos recursos y no hay programas gubernamentales permanentes con incentivos econó- micos que impulsen el deporte del canotaje. El rendimiento deportivo parece ser una cualidad personal que se desprende de la capacidad física y que se afina por la práctica y la constancia.
La Escuela Nacional de Maestros y el profesorado disidente de la Ciudad de México: procesos de memoria desde la resistencia
Authors:   Instituto Politécnico Nacional, Páez Cárdenas Juan
Published: October 2022

El objetivo de este trabajo es explorar el proceso de memoria del profesorado disidente de la Ciudad de México con relación a su formación en la Escuela Nacional de Maestros en un periodo de resistencia contra la reforma educativa de 2013. El estudio se desprende de una investigación más amplia bajo la perspectiva etnográfica. Documentar estas memorias contribuye a la comprensión de la identidad del movimiento magisterial disidente y al registro de las voces de los grupos subalternos. Los hallazgos muestran un hábito social de memoria y un uso estratégico del pasado vinculado a un proceso de reforzamiento identitario como sujeto político.
ANALISIS FAKTOR YANG BERPENGARUH TERHADAP PEMBENGKAKAN BIAYA SELAMA PELAKSANAAN PROYEK DI MASA PANDEMI COVID-19 PADA PELAKU JASA KONSTRUKSI SKALA KECIL DI BALI
Authors: Laksmi Ida Ayu Cri Vinantya , Jawat I Wayan , Armaeni Ni Komang
Published: October 2022

Pandemi virus Covid-19 yang melanda Indonesia, khususnya Bali sangat berdampak pada kehidupan masyarakat. Hal tersebut memberikan dampak pada beberapa sektor, mulai dari sektor kesehatan, ekonomi, pendidikan, pariwisata termasuk sektor pembangunan. Wabah Corona memaksa semua negara untuk merevisi perencanaan pembangunan yang telah dicanangkan. Target disesuaikan secara realistis, asumsi diubah sesuai keadaan sekarang, dan prioritas program jangka pendek dialihkan sebagian besar untuk mengatasi pandemi Covid-19. Dalam rangka percepatan pembangunan untuk memulihkan kondisi perekonomian, beberapa pelaku jasa konstruksi skala kecil masih bisa melaksanakan pembangunan meskipun harus mengalami beberapa kendala. Selama melaksanakan pembangunan di tengah pandemi, tentunya ada beberapa biaya yang mengalami perubahan yang cukup signifikan bahkan dapat menyebabkan pembengkakan biaya. Pembengkakan biaya proyek konstruksi sangat tergantung dari beberapa faktor, baik faktor internal maupun faktor eksternal proyek. Beberapa factor yang sangat berpengaruh dalam pembengkakan biaya selama pelaksanaan proyek yang dilakukan oleh pelaku jasa kontruksi skala kecil di masa pandemi Covid-19, antara lain: estimasi biaya tidak tepat (9,33%),  kesalahan dalam memilih metode pengerjaan (8,84%), produktivitas tenaga kerja yang rendah (8,15%), kesalahan dimensi/ukuran pekerjaan dalam pelaksanaan (8,14%), sering terjadi penundaan pekerjaan (8,04%), keterlambatan jadwal karena pengaruh cuaca (8,00%), adanya kenaikan harga material (7,94%), harga/sewa peralatan yang tinggi (7,67%), terlambat/kekurangan bahan dan material (7,31%), kerusakan material (6,81%), spesifikasi bahan yang tidak cocok (6,52%), dan cara pembayaran yang tidak tepat waktu (6,26%).
KAJIAN PEMANFAATAN MATRAS BAMBU PADA PERBAIKAN NILAI CALIFORNIA BEARING RATIO (CBR) TANAH LEMPUNG
Authors: Waruwu Aazokhi , ZEGA Memotani , ENDRIANI Debby , SUSANTI Rika Deni
Published: October 2022

Tanah lempung memiliki daya dukung, stabilitas, dan nilai CBR (California Bearing Ratio) yang rendah. Tanah dasar dengan CBR rendah perlu perkuatan untuk memperbaiki sifat mekanis dan meningkatkan daya dukung ketika pelaksanaan pemadatan dan penghamparan tanah dengan alat berat dan saat beban kendaraan bekerja di atas permukaan jalan. Material bambu berpotensi digunakan sebagai perkuatan tanah lempung. Tujuan penelitian ini adalah untuk mengetahui pengaruh perkuatan matras bambu tipe anyam dan nir-anyam dan pengaruh jumlah lapis perkuatan terhadap nilai CBR. Perkuatan matras bambu dibedakan tipe anyam dan nir-anyam sebanyak 3 dan 5 lapis dengan jumlah pukulan pada benda uji CBR sebanyak 25 dan 56 pukulan. Uji CBR dilakukan pada lempung tanpa perkuatan dan dengan perkuatan. Nilai CBR tanah yang diperkuat matras bambu nir-anyam didapatkan sebesar 4,4-5,06%, sedangkan nilai CBR untuk tanah dengan perkuatan matras bambu anyam sebesar 4,56-5,30%. Susunan matras bambu tipe anyam lebih rapat dan terikat satu sama lain, sehingga lebih kokoh dan stabil dalam menerima beban. Jumlah lapis perkuatan dengan spasi vertikal yang lebih rapat menghasilkan nilai CBR yang lebih tinggi dari jumlah lapis perkuatan yang lebih sedikit. Spasi vertikal yang lebih rapat dapat memperluas bidang kontak tekanan, sehingga beban yang dapat dipikul semakin tinggi. Matras bambu tipe anyam dengan jumlah lapis lebih banyak didapatkan memiliki kinerja yang baik dalam meningkatkan nilai CBR tanah dasar untuk konstruksi jalan.
Farmer Resilience in Maintaining Agricultural Production During the COVID-19 Pandemic: Study in Solokuro Subdistrict, Lamongan
Authors: Izzah Iva Yulianti Umdatul , Jazilah Husainatul
Published: October 2022

This research examines how the lives of farmers in rural Lamongan during the pandemic, the challenges faced by farmers during the pandemic, and the forms of resilience that farmers take in maintaining their agricultural productivity in the pandemic era. Data was collected using qualitative research methods and a case study approach to show how farmers carried out the form of resilience in rural areas in Lamongan Regency during the COVID-19 pandemic. There were eight informants whose data were extracted in this research consisting of four male farmers and four female farmers. Observations and interviews with informants were carried out from July to October 2020. This research occurred in a rural area, namely in Dadapan Village, Solokuro Subdistrict, Lamongan Regency, East Java, considering that farmers in the village still carry out farming activities even though they are in a pandemic condition. From this research, it can be seen that farmers in Dadapan Village are the affected parties during the pandemic and must make efforts to survive. The challenge farmers face the losses experienced due to difficulties in marketing their agricultural products. Farmers’ resilience forms include, first, continuing to do farming during this pandemic while still paying attention to health protocols; second, creating marketing strategies for their agricultural products online; and third, maintaining their enthusiasm to continue farming.
Socio-psychological factors of personnel management in the context of tourist enterprises development
Authors: Shukanova A. , Vishnikina L. , Volodko O. , Dudnyk S.
Published: October 2022

In modern conditions, which have had a devastating effect on the activities of tourism enterprises, the main tasks remain their preservation and development. Tourism as an industry has a great contribution to the national economy, as it not only provides paid services to the population, but also increases the number of jobs in such industries as transport, construction, hotel and restaurant industry, crafts, museums and more. Personnel management at tourism enterprises should be carried out taking into account the changing environmental conditions, changes in legislation, the ability to carry out tourism activities through hostilities in general. Characteristics of personnel management in crisis conditions of tourist enterprises functioning are considered and social and psychological factors as indicators of activity efficiency are allocated. The article considers the main trends in the functioning of tourist enterprises in the pre-war period, as the war caused almost complete destruction of the tourism sector. Taking into account the current circumstances, the possibilities of forming a motivational mechanism in tourism enterprises, which should be based not on material motivation and wages, but more on labor and status motivation and provide various forms of career advancement, corporate training, development of flexible work schedules and work seats optimization. Psychological factors of personnel management are proposed to be considered in terms of increasing the stress resistance of workers in changing conditions. Among the proposed measures are low-cost opinion polls on the characteristics of stress (loss of appetite or excessive appetite, sleep disturbances, chronic fatigue, rapid speech, loss of humor, irritability, frequent mistakes, unexplained headaches, stomach upset, alcoholism and smoking etc.) at enterprises that allow to identify the level of stress and stress resistance of employees, as well as measures to overcome stress, which are part of corporate culture and promote the tourism enterprises development.
Greening of economy in the context of implementation of the sustainable developmentconcept: theoretical aspect
Authors: Korolchuk L.
Published: October 2022

The article examines the theoretical aspect of greening the economy as a process that accompanies the implementation of the sustainable developmentconcept,as a modern paradigm of the global world order. Achieving the Sustainable Development Goals is a priority of socio-economic strategies of developed countries and for Ukraine, which has already proved its belonging to a progressive democratic world, it is important to ensure high-quality transformation of the economy in accordance with world standards .It is established the relationship between greening the economy and sustainable development using the method of analysis of existing definitions of «green economy» among international organizations, foreign and domestic researchers to identify the main points in their meanings in the context of sustainable development; the quintessence of the concept of «green economy» is clarified on the basis of identified common provisions in groups by authorship of definitions; the nature of the relationship between the concepts of «sustainable development» and «green economy» is determined. According to the results of the study, the definition of «greening the economy» is given, which, although it coincides with the concept of «green economy», but means a process, not a result. In the context of ensuring the process of greening the economy as a way to achieve sustainable development, relevant tools that can be used in this process have been studied. Based on theoretical and empirical approaches, the tools of greening the economy are divided into three packages according to the three dimensions of sustainable development and describe the content of all proposed packages: tools to ensure the economic dimension of sustainable development, tools to ensure the social dimension of sustainable development and tools to ensure the environmental dimension of sustainable development.The problem of the need to adapt the process of greening the economy of Ukraine to the conditions of war was raised. It is proposed to expand the range of sustainable development to another dimension – military with a focus on military decoupling, as a promising area of research in the near future in the context of improving the security situation in the world in harmony with the environment.
浅析水利工程中水闸工程施工技术
Authors: 王 克锋
Published: October 2022

我国地质资源相对较为丰富，但地势环境也比较复杂，而且水资源分布不均匀，经常许多地区会出现洪水灾害，为了保障人民的生命财产安全，我国加大了水利工程建设力度，为了提高了防洪能力，并加大了投资力度建设电力枢纽工程，为此为人们的幸福生活奠定良好基础。不过在工程建设的过程中，如果水闸工程施工技术在实际应用的过程中，出现了质量问题，对整体水利工程造成质量影响，那么很容易受到洪水危害。为此，本篇文章水闸工程施工技术进行合理分析，以此确保水利工程建设质量。
水利工程施工中防渗技术的运用探索
Authors: 崔 凌云
Published: October 2022

水利工程的建设与社会的发展有着较为密切的关系，随着经济与科技的发展，人们对水资源的需求呈上升趋势，但根据水利工程现阶段的进程来看，在对水资源防渗控制时，仍存在诸多不合理之处。例如水利工程经常出现渗漏的现象，阻碍了水利工程后续的发展，给社会造成了经济损失。针对此问题，河南省水利第一工程局技术人员应不断开发和探索先进的水利工程防渗技术，掌握防渗技术应用的要点，解决水利工程渗漏的问题，提高水利工程施工效率。此文研究了水利工程当中防渗问题出现的原因，进而对防渗技术的优化路径进行了分析和讨论。
长螺旋钻孔灌注桩在水利工程中的应用研究
Authors: 赵 子莹 , 陈 君
Published: October 2022

当前水利工程在我国各个行业发展当中都能起到重要的意义，是保证我国经济社会发展的重要工程项目，因此需要采用各种施工工艺实现水利工程质量的提升。文中首先简要阐述了长螺旋钻孔灌注桩在水利工程中应用的工艺特点与原理和其应用存在的问题，接着重点讨论了长螺旋钻孔灌注桩在水利工程中的应用要点，旨在提高水利工程施工的质量，强化工程功能性。
电气工程及自动化技术在电力系统中应用分析
Authors: 黄 晓旭
Published: October 2022

电力作为人类生产工作的主要能源，在社会发展中占据着重要的位置。因此，保障电力系统的安全性与稳定性具有十分重要的意义。伴随着社会用电量需求的不断增加，电力系统的运行要求也随之提升，落后的管理技术已经无法满足电力事业的发展要求。通过电气工程及其自动化技术在电力系统自动化发展中的应用，为建设智能电力系统提供了有效路径。
基于BIM的水利工程施工管理模式及应用流程
Authors: 章 刚
Published: October 2022

目前BIM技术的研发和运用大多集中于工程项目设计阶段，将其作为建筑管理模式的较少且尚不完善。本章首先以传统水利工程项目为出发点，体系剖析了BIM技术运用在建筑施工管理中的特征与优点，在传统水利工程管理基础上，融入BIM团队，给出了最适合于现代水利施工的应用模型，并建立了采用三个层面(数据层、处理层、应用层)、2个管理系统(仿真BIM管理系统、即时BIM管理系统)的管理平台，最后一章再以土石坝施工为例，综合设计了仿真BIM管理系统和即时BIM管理系统的具体实施过程。
水利工程施工中防渗技术探讨
Authors: 萨 如拉
Published: October 2022

水利工程的建设可以促进社会的发展和进步，不仅可以带来巨大的经济效益，还可以带来良好的社会和环境效益，改善自然生态。然而，水利工程建设中的渗漏问题往往会破坏整个结构，增加水利工程安全运行的风险。文章探讨了水利工程渗漏事故的成因，深入探讨了水利工程施工中的防渗技术，以获得更好的防渗效果。
水土保持措施适宜性评价的理论与方法初探
Authors: 孙 李品
Published: October 2022

现如今，我们的国家飞速发展，社会经济水平在不断提升，人们逐渐开始关注环境问题，而对于我们水利行业来说，要想在这个经济飞速发展的时代存活就必须要采取一些水土保持措施，因为它不仅与社会经济的发展息息相关也关系到人们的生活起居。合理的水土保持措施，不仅能够保护生态环境，还能促进生态环境与当地的社会经济发展相协调。
A Case of Rapid Growing Myoepithelioma of the Maxillary Sinus
Authors: Oh Jang Won , Park Chae Jung , Choi Yoon Jung , Ha Jong-Gyun
Published: October 2022

Myoepithelioma is a rare tumor of the salivary glands. Occurrence of myoepithelioma in the nasal cavity is even rarer, and there has been no case wherein the change in the size of the tumor was confirmed by imaging. In this report, a 84-year-old female was found to have a rapidly enlarged tumor on the preoperative image, but she had shown no significant size change in a medical examination six months ago or in the paranasal sinuses view three months ago. The image showed a rapid increase in the size of the cystic component, so the endoscopic medial maxillectomy was performed. There was no recurrence of the tumor at follow-up six months after surgery. Although myoepithelioma is rarely found in the maxillary sinus of the sinonasal cavity, it is important to suspect myoepithelioma and consult a pathologist if it shows a similar pattern to the current case.
Hyalinizing Clear Cell Carcinoma of the Base of Tongue Mistaken for Benign Lesion: A Case Report
Authors: Kim Min Gyu , Heo Da Beom , Moon Seong Jun , Koo Bon Seok
Published: October 2022

Hyalinizing clear cell carcinoma (HCCC) is a rare, low-grade malignant tumor of the salivary gland. It usually originates from the minor salivary gland, with the most common site being the palate, followed by the lips and the buccal mucosa. The occurrence of HCCC at the base of the tongue (BOT) is extremely uncommon, thus it must be differentiated from other malignant clear cell tumors. Immunohistochemistry is a useful tool to make an appropriate diagnosis. To obtain the best prognosis for HCCC, complete surgical resection is necessary. Here we report a case of a 47-year-old male with a benign-looking neoplasm in the right BOT, presenting with throat discomfort. A simple excisional biopsy revealed proliferative nests of clear cells within a hyalinized fibrous connective tissue. The final diagnosis by immunohistochemistry was HCCC with a positive resection margin. Re-operation secured a safety margin, and the lesion was completely resected.
Providing Health Education as an Effort to Improve Knowledge and Prevention of COVID-19 for Persons with Disabilities, PPDMS Social Institutions, Nglipar, Gunungkidul
Authors: Widagdo The Maria Meiwati , Manus Widya Christine , Frista Frista , Indonesia Matahari Bunga
Published: October 2022

People with disabilities are vulnerable to being infected with the COVID-19 virus. The COVID-19 pandemic has had an impact on human life, including the health of people with disabilities. The government makes various policies and programs in an effort to prevent the spread of COVID-19, but their implementation is still challenging for people with disabilities. This community service program was carried out in collaboration with Mitra Sejahtera Disability Empowerment Center (PPDMS), an organization empowering people with disabilities in Gunungkidul Regency. Empowerment of people with disabilities was carried out using 'community control' principle in which the community has the control in making decisions regarding the problems they face so that they can adopt a ‘new normal’ lifestyle because of their knowledge. The principle of 'community control' was applied by providing education about COVID-19 situation in Indonesia, the symptoms and signs of COVID-19 infection, wash hands, proper cough etiquette, how to use masks, food and lifestyle that can prevent COVID-19 transmission, as well as about the benefits of COVID-19 vaccination. Education was given with a presentation followed by discussion. Evaluation was carried out quantitatively and qualitatively. Quantitative evaluation using pretest and post-test showed an increase in knowledge.  Qualitative evaluation using FGD indicated changes in attitudes and behavior that support the adoption of ‘new normal’ lifestyle to prevent transmission of COVID-19. People with disabilities who have received education disseminate the information obtained to other people with disabilities, resulted in multiplication effect of this empowerment program for people with disabilities.
Medicine Consumption Reminder and Monitoring Application for Patients with Leprosy Disease
Authors: Irawan Paulus Lucky Tirma , Hartanto Calvin Brylland Septhanya , Kelana Oesman Hendra
Published: October 2022

Leprosy or also known as Hansen's disease (HD) or Morbius Hansen's disease (MHD) caused by the bacterium Mycobacterium leprae. The symptoms of leprosy are hardly identified. In fact, some symptoms only can be identified after 20-30 years. Recently, the advent of multidrug therapy (MDT) and the use of anti-inflammatory therapies have given substantial improvements in long-term health outcomes for patients diagnosed with leprosy. However, the medication was a time consuming. Healthy behavior in the management of leprosy treatment requires discipline in taking leprosy medication. On the contrary, poor treatment management will lead to permantent consequnces of disability and deformity. Various Android-based applications have been developed by programmers. Smartphone technology is expected to help patients taking medication in supervising and reminding. In addition, through the cloud based technology the mobile application is expected to be solution as medium of information and communication for every stake holder in dealing with leprosy patients. This research involves a series of software development processes which are divided into several phases. Starting with the identification of the problem, moving on to the design of the application and the API service, to the development and testing of the application using a variety of test scenarios, and concluding with the documentation process.  Both the functionality and the design were tested using the User Experience Questionnaire (UEQ) and black-box testing. Based on the outcomes of black box testing, the app's functionality work without any issues. The UEQ results show that novelty (Good), stimulation (Good), efficiency (Good), reliability (Above Average), perspicuity (Above Average), and beauty (Good) are all positive (Above Average). According to the UEQ results, the application received the highest efficiency level rating of 1.75, which indicates that it is regarded as having good consumption efficiency and being usable.
Utilization and Processing of Starfruit into Various Food Products in Watesari Village, Balongbendo District, Sidoarjo Regency
Authors: Ambari Yani , Nadia Cindy , Purwanti Dyah Mega , Putri Karina , Fajar Nivia , Amalia Rita , Ifadah Shintia , Anami Sholihul , Tejo Sukarno , Agtian Wahyu
Published: October 2022

Starfruit is a fruit plant in the form of a tree originating from Malaysia, then spread widely to various other tropical countries including Indonesia. Sweet starfruit has various benefits for the health of the body. The content in star fruit can also be used for the prevention of diseases including getting rid of sore throat, cough, and fever, suppressing diabetic symptoms, also reducing high cholesterol. The processing of star fruit into various food products namely jam, ice cream, jelly candy, and pudding is carried out by the community service team of the Bachelor of Pharmacy Study Program, at Anwar Medika University. This utilization and processing are two of the tangible forms of improving the Watesari Village’s economy. The activities include counselling, processing, and distribution of various food products from star fruit. The activities that were carried out received a positive response from the Village Headman and Watesari Village residents. The Watesari Village community was very enthusiastic when distributing various food products made from star fruit.
Harnessing the Incretin System with Multi-Agonists
Authors: Whyte Martin B , Heald Adrian , Field Benjamin CT
Published: October 2022

The scientific community has made great strides in responding to the huge public health problems of obesity and diabetes with the discovery of the incretin system and the development of glucagon-like peptide 1 analogues. These have shown clinical efficacy in randomised controlled trials and observational data from real-world evidence; however, a ‘treatment gap’ remains between the therapeutic success of these molecules and the outcomes achieved with bariatric surgery. To help address this, dual incretins are being developed. These combine glucagon-like peptide 1 action with that of either glucose-dependent insulinotropic peptide or glucagon. This narrative review charts the development of incretin therapy, and the dual agonists for treatment of Type 2 diabetes and obesity.
Science Learning with The Qur'an and Hadith Through Audiovisual Media (Video) to Improve Concept Mastery and Religious Attitude
Authors: Annas Ibni , Permana Irvan
Published: October 2022

This study aims to improve students' concept mastery and religious attitudes in science learning with the Quran and Hadith contents through audiovisual media (video). The research design was quasi-experimental, with experimental and control classes as the research subjects. Data were collected using a test to measure students' concept mastery and religious attitudes with 30 questions, an observation sheet, and a questionnaire with 22 questions. The measurement results of the two test forms were analyzed in N-Gain, while the observation sheets were analyzed descriptively. Students' responses were analyzed in percentage. The results showed that students who learned using the Qur'an and Hadith content through the media were much better than through non-media learning. The N-Gain score for concept mastery was 50.77% (medium) and 38.56% (medium), while for religious attitude was 3.25 (good) and 3.61 (very good). This study proves that the implementation of science learning with the content of the Qur'an and Hadith in teaching and learning activities is quite good, and students' responses to the learning implementation are quite high.
Whose Turn Now? The Enactment & Expansion of Private School Choice Programs across the US
Authors: Sude Yujie , Wolf Patrick
Published: October 2022

Private school choice policies have been enacted and expanded across the United States since the 1990s. Why have some states adopted and expanded this education reform while others have demurred? Which states are more likely to adopt specific types of private school choice initiatives in the coming years? We present the results of an exploratory empirical analysis of data through 2016 examining these questions. The results from our most preferred statistical model further predict which states are more and less likely to take action towards such policies in subsequent years. The political factors involving Republican control of the governorship and legislature, prevalence of minority students in the K-12 population and share of private school enrollment in the state prove to be highly predictive factors in school choice adoption. The economic factor of a comparatively low state per-capita GDP also consistently predicts school choice policy adoption in our models.
Civil Wars as Critical Junctures: Theoretical Grounding and Empirical Applications
Authors: Thaler Kai
Published: October 2022

Civil wars are not only destructive: they can also give birth to new, long-lasting social, political, and economic structures and processes. I argue that we should in fact view civil wars as critical junctures. Civil wars relax structural constraints, opening opportunities for changes generated by wartime processes, while war's end can lock in these changes, creating path dependency. Government victory may foreclose change (critical junctures do not necessarily lead to transformation), but governments can also make lasting reforms in response to conflicts. Rebel victory has major potential for statebuilding and societal transformation, while negotiated settlements can institutionalize a new balance of domestic political power. I illustrate the benefits of a critical junctures approach to civil wars in the literature on wartime and postwar women’s empowerment, and I discuss how a critical junctures framework may prove useful for civil war studies employing methods beyond comparative historical analysis.
Engineering collagenous analogs of connective tissue extracellular matrix
Authors: Brudnicki Philip A. P. , Gonsalves Matthew A. , Spinella Stephen M. , Kaufman Laura J. , Lu Helen H.
Published: October 2022

Connective tissue extracellular matrix (ECM) consists of an interwoven network of contiguous collagen fibers that regulate cell activity, direct biological function, and guide tissue homeostasis throughout life. Recently, ECM analogs have emerged as a unique ex vivo culture platform for studying healthy and diseased tissues and in the latter, enabling the screening for and development of therapeutic regimen. Since these tissue models can mitigate the concern that observations from animal models do not always translate clinically, the design and production of a collagenous ECM analogue with relevant chemistry and nano- to micro-scale architecture remains a frontier challenge in the field. Therefore, the objectives of this study are two-fold— first, to apply green electrospinning approaches to the fabrication of an ECM analog with nanoscale mimicry and second, to systematically optimize collagen crosslinking in order to produce a stable, collagen-like substrate with continuous fibrous architecture that supports human cell culture and phenotypic expression. Specifically, the “green” electrospinning solvent acetic acid was evaluated for biofabrication of gelatin-based meshes, followed by the optimization of glutaraldehyde (GTA) crosslinking under controlled ambient conditions. These efforts led to the production of a collagen-like mesh with nano- and micro-scale cues, fibrous continuity with little batch-to-batch variability, and proven stability in both dry and wet conditions. Moreover, the as-fabricated mesh architecture and native chemistry were preserved with augmented mechanical properties. These meshes supported the in vitro expansion of stem cells and the production of a mineralized matrix by human osteoblast-like cells. Collectively these findings demonstrate the potential of green fabrication in the production of a collagen-like ECM analog with physiological relevance. Future studies will explore the potential of this high-fidelity platform for elucidating cell-matrix interactions and their relevance in connective tissue healing.
Identification of the safe(r) by design alternatives for nanosilver-enabled wound dressings
Authors: Cazzagon V. , Giubilato E. , Bonetto A. , Blosi M. , Zanoni I. , Costa A. L. , Vineis C. , Varesano A. , Marcomini A. , Hristozov D. , Semenzin E. , Badetti E.
Published: October 2022

The use of silver nanoparticles (NPs) in medical devices is constantly increasing due to their excellent antimicrobial properties. In wound dressings, Ag NPs are commonly added in large excess to exert a long-term and constant antimicrobial effect, provoking an instantaneous release of Ag ions during their use or the persistence of unused NPs in the wound dressing that can cause a release of Ag during the end-of-life of the product. For this reason, a Safe-by-Design procedure has been developed to reduce potential environmental risks while optimizing functionality and costs of wound dressings containing Ag NPs. The SbD procedure is based on ad-hoc criteria (e.g., mechanical strength, antibacterial effect, leaching of Ag from the product immersed in environmental media) and permits to identify the best one among five pre-market alternatives. A ranking of the SbD alternatives was obtained and the safer solution was selected based on the selected SbD criteria. The SbD framework was also applied to commercial wound dressings to compare the SbD alternatives with products already on the market. The iterative procedure permitted to exclude one of the alternatives (based on its low mechanical strength) and proved to be an effective approach that can be replicated to support the ranking, prioritisation, and selection of the most promising options early in the innovation process of nano-enabled medical devices as well as to encourage the production of medical devices safer for the environment.
Genetic variation in placental insufficiency: What have we learned over time?
Authors: Wang Li Qing , Fernandez-Boyano Icíar , Robinson Wendy P.
Published: October 2022

Genetic variation shapes placental development and function, which has long been known to impact fetal growth and pregnancy outcomes such as miscarriage or maternal pre-eclampsia. Early epidemiology studies provided evidence of a strong heritable component to these conditions with both maternal and fetal-placental genetic factors contributing. Subsequently, cytogenetic studies of the placenta and the advent of prenatal diagnosis to detect chromosomal abnormalities provided direct evidence of the importance of spontaneously arising genetic variation in the placenta, such as trisomy and uniparental disomy, drawing inferences that remain relevant to this day. Candidate gene approaches highlighted the role of genetic variation in genes influencing immune interactions at the maternal-fetal interface and angiogenic factors. More recently, the emergence of molecular techniques and in particular high-throughput technologies such as Single-Nucleotide Polymorphism (SNP) arrays, has facilitated the discovery of copy number variation and study of SNP associations with conditions related to placental insufficiency. This review integrates past and more recent knowledge to provide important insights into the role of placental function on fetal and perinatal health, as well as into the mechanisms leading to genetic variation during development.
Dengue virus downregulates TNFR1- and TLR3-stimulated NF-κB activation by targeting RIPK1
Authors: Udawatte Darshika J. , Lang Diane M. , Currier Jeffrey R. , Medin Carey L. , Rothman Alan L.
Published: October 2022

Dengue virus (DENV) infection is the most prevalent arthropod-borne virus disease and is endemic in more than 100 countries. Several DENV proteins have been shown to target crucial human host proteins to evade innate immune responses and establish a productive infection. Here we report that the DENV NS3 protein targets RIPK1 (Receptor Interacting Protein Kinase I), a central mediator of inflammation and cell death, and decreases intracellular RIPK1 levels during DENV infection. The interaction of NS3 with RIPK1 results in the inhibition of NF-κB activation in response to TNFR or TLR3 stimulation. Also, we observed that the effects of NS3 on RIPK1 were independent of NS3 protease activity. Our data demonstrate a novel mechanism by which DENV suppresses normal cellular functions to evade host innate immune responses
Kinetics of monocyte subpopulations during experimental cerebral malaria and its resolution in a model of late chloroquine treatment
Authors: Royo Jade , Camara Aissata , Bertrand Benedicte , Batigne Philippe , Coste Agnes , Pipy Bernard , Aubouy Agnes ,   the NeuroCM Group
Published: October 2022

Cerebral malaria (CM) is one of the most severe forms of malaria and is a neuropathology that can lead to death. Monocytes have been shown to accumulate in the brain microvasculature at the onset of neurological symptoms during CM. Monocytes have a remarkable ability to adapt their function to their microenvironment from pro-inflammatory to resolving activities. This study aimed to describe the behavior of monocyte subpopulations during infection and its resolution. C57BL/6 mice were infected with the Plasmodium berghei ANKA strain and treated or not with chloroquine (CQ) on the first day of the onset of neurological symptoms (day 6) for 4 days and followed until day 12 to mimic neuroinflammation and its resolution during experimental CM. Ly6C monocyte subpopulations were identified by flow cytometry of cells from the spleen, peripheral blood, and brain and then quantified and characterized at different time points. In the brain, the Ly6Cint and Ly6Clow monocytes were associated with neuroinflammation, while Ly6Chi and Ly6Cint were mobilized from the peripheral blood to the brain for resolution. During neuroinflammation, CD36 and CD163 were both involved via splenic monocytes, whereas our results suggest that the low CD36 expression in the brain during the neuroinflammation phase was due to degradation. The resolution phase was characterized by increased expressions of CD36 and CD163 in blood Ly6Clow monocytes, a higher expression of CD36 in the microglia, and restored high expression levels of CD163 in Ly6Chi monocytes localized in the brain. Thus, our results suggest that increasing the expressions of CD36 and CD163 specifically in the brain during the neuroinflammatory phase contributes to its resolution.