bluuebunny/crossref_metadata_2025 huggingface dataset:
Constraining the top-quark mass within the global MSHT PDF fit
Authors: Cridge Thomas , Lim Matthew A.
Published: September 2023

We examine the ability of experimental measurements of top-quark pair production to constrain both the top-quark mass and the strong coupling within the global MSHT parton distribution function (PDF) fit. Specifically, we consider ATLAS and CMS measurements of differential distributions taken at a centre-of-mass energy of 8 TeV, as well as $$ t\bar{t}$$

t

t

¯

total cross section data taken at a variety of experiments, and compare to theoretical predictions including next-to-next-to-leading order corrections. We find that supplementing the global fit with this additional information results in relatively strong constraints on the top-quark mass, and is also able to bound the strong coupling in a limited fashion. Our final result is $$m_t=173.0\pm 0.6~\textrm{GeV}$$

m
t

=
173.0
±
0.6

GeV

and is compatible with the world average pole mass extracted from cross section measurements of $$172.5\pm 0.7~\textrm{GeV}$$

172.5
±
0.7

GeV

by the Particle Data Group. We also study the effect of different top-quark masses on the gluon parton distribution function, finding changes at high x which nonetheless lie within the large PDF uncertainties in this region.
A realistic coalescence model for deuteron production
Authors: Mahlein Maximilian , Barioglio Luca , Bellini Francesca , Fabbietti Laura , Pinto Chiara , Singh Bhawani , Tripathy Sushanta
Published: September 2023

A microscopic understanding of (anti)deuteron production in hadron–hadron collisions is the subject of many experimental and theoretical efforts in nuclear physics. This topic is also very relevant for astrophysics, since the rare production of antinuclei in our Universe could be a doorway to discover new physics. In this work, we describe a new coalescence afterburner for event generators based on the Wigner function formalism and we apply it to the (anti)deuteron case, taking into account a realistic particle emitting source. The model performance is validated using the EPOS and PYTHIA event generators applied to proton–proton collisions at the centre-of-mass energy $$\sqrt{s}= 13$$

s

=
13

 TeV, triggered for high multiplicity events, and the experimental data measured by ALICE in the same collision system. The model relies on the direct measurement of the particle emitting source carried out by means of nucleon–nucleon femtoscopic correlations in the same collision system and energy. The resulting model is used to predict deuteron differential spectra assuming different deuteron wavefunctions within the Wigner function formalism. The predicted deuteron spectra show a clear sensitivity to the choice of the deuteron wavefunction. The Argonne $$v_{18}$$

v
18

wavefunction provides the best description of the experimental data. This model can now be used to study the production of (anti)deuterons over a wide range of collision energies and be extended to heavier nuclei.
Combined analysis on nature of X(3960), $$\chi _{c0}(3930)$$, and $$X_0(4140)$$
Authors: Ding Zuo-ming , He Jun
Published: September 2023

In this work, a study of the $$D_s{\bar{D}}_s$$

D
s

D

¯

s

interaction and its couplings to the channels $$D{\bar{D}}$$

D

D

¯

and $$J/\psi \phi $$

J
/
ψ
ϕ

is performed in a quasipotential Bethe–Salpeter equation approach. The $$D_s^+{D}_s^-$$

D
s
+

D
s
-

and $$D^+{D}^-$$

D
+

D

-

invariant mass spectra in three-body B decays are investigated in order to understand the origin of X(3960), $$\chi _{c0}(3930)$$

χ

c
0

(
3930
)

, and $$X_0(4140)$$

X
0

(
4140
)

structures reported at LHCb. With the help of effective Lagrangians, the potential kernel can be constructed with meson exchanges, from which the scattering amplitudes can be obtained. By inserting it into the three-body decay processes, the invariant mass spectra can be calculated with an additional Breit–Wigner resonance introduced. The $$D_s^+{D}_s^-$$

D
s
+

D
s
-

invariant mass spectrum in the decay process $$B^+\rightarrow D^+_sD^-_sK^+$$

B
+

→

D
s
+

D
s
-

K
+

is well reproduced, and the X(3960) structure can be explained as a molecular state from the $$D_s{\bar{D}}_s$$

D
s

D

¯

s

interaction. The state also exhibits as a peak in the $$D^+{D}^-$$

D
+

D

-

invariant mass spectrum in the decay $$B^+\rightarrow D^+D^-K^+$$

B
+

→

D
+

D
-

K
+

, however, it is too narrow to reproduce the experimental structure around 3930 MeV. The dip around 4140 MeV in the $$D_s^+{D}_s^-$$

D
s
+

D
s
-

invariant mass spectrum can be reproduced by the additional resonance with interference effect. However, a small bump instead of a dip is produced from the $$D_s{\bar{D}}_s-J/\psi \phi $$

D
s

D

¯

s

-
J
/
ψ
ϕ

coupled-channel effect, which suggests that the $$X_0(4140)$$

X
0

(
4140
)

cannot be interpreted as the $$D_s{\bar{D}}_s-J/\psi \phi $$

D
s

D

¯

s

-
J
/
ψ
ϕ

coupling in the current model.
Colliding cratons: linking the Variscan Orogeny in West Africa and North America
Authors: Villeneuve Michel , Gärtner Andreas , Mueller Paul A. , Guillou Omar , Linnemann Ulf
Published: September 2023

The Variscan Orogen was formed during the closure of the Rheic Ocean and the final collision between the North American and West African cratons in the Late Paleozoic. This collision led to the multistage building of the Mauritanide Belt to the east of the Variscan suture and to the building of the well-known Appalachian Belt to the west. Both led to opposite vergences in this part of the Variscan belt. The earliest records of the main collision episode begin at ∼360 Ma and end about 250 myr ago, while a late extensional phase lasted until ∼190 Ma. Three distinct stages are recognized in West Africa. The first stage (
c.
350–300 Ma) records the indentation of the Reguibat Shield into the central Appalachian margin of Laurentia. This indentation led to thrusting of the Souttoufide and Akjoujt ‘nappes’ onto the Reguibat Shield, to southward motion of the Senegalese block (SB), and to strike-slip motion in the Appalachians. The motion of the SB to the south is coeval with: (1) folding of the northern part of the Bové Basin, (2) north–south sinistral strike-slip motions in the central Mauritanides, and (3) the end of sedimentation in the Bové and Taoudeni Basins by the Late Devonian. The second stage (
c.
300–250 Ma) involves the eastward motion of the Western Thrust Block (WTB) against the SB and, likely, some of the westward thrusts in the Appalachians. This second ‘Variscan’ event includes: (1) closure of parts of the lower Diourbel Carboniferous basin, which is now concealed beneath the Senegalo-Mauritanian Basin, (2) thrusting to the east of the Simenti Group over the Koulountou Group in the Bassaride Belt, (3) thrusting to the east of the Wa-Wa Group, (4) thrusting of the Mauritanide Belt onto the Taoudeni Basin in the central Mauritanide Belt, and finally (5) thrusting of the Agualilet Group over the Akjoujt nappes and eastward motion of the western units over the Dhloat Ensour (Late Ordovician to early Devonian) autochthonous unit in the Souttoufides. West of the supposed ‘Variscan’ suture, Appalachian thrusting affected parts of Appalachian Belt. The third stage (
c.
250 to 190 Ma) began with the opening of Triassic rift basins in the Senegalo-Mauritanian basin and also in the north of Florida. As numerous previous correlations across the Variscan system do not include the West African part, our sythesis is intended to enhance these correlations.
Semi-Automatic Building and Learning of a Multilingual Ontology
Authors: Mesmia Fatma Ben , Mouhoub Malek
Published: September 2023

Most online platforms, applications, and Websites use a massive amount of heterogeneous evolving data. These data must be structured and normalized before integration to improve the search and increase the relevance of results. An ontology can address this critical task by efficiently managing data and providing structured formats through techniques such as the Web Ontology Language (OWL). However, building an ontology can be costly, primarily if conducted manually. In this context, we propose a new methodology for automatically building and learning a multilingual ontology using Arabic as the base language via a corpus collected from Wikipedia. Our proposed methodology relies on Finite-state transducers (FSTs). FSTs are regrouped into a cascade to reduce errors and minimize ambiguity. The produced ontology is extended to English and French and independent language images via a translator we developed using APIs. The rationale for starting with the Arabic corpus to extract terms is that entity linking is more convenient from Arabic to other languages. In addition, many Wikipedia articles in English and French (for instance) do not have associated Arabic articles, but the opposite is true. In addition, dealing with Arabic terms permits us to enrich the Arabic module of the free linguistic platform we use in dictionaries and graphs. To assess the efficiency of our proposed methodology, we conducted performance metrics. The reported results are encouraging and promising.
From Missteps to Milestones: A Journey to Practical Fail-Slow Detection
Authors: Lu Ruiming , Xu Erci , Zhang Yiming , Zhu Fengyi , Zhu Zhaosheng , Wang Mengtian , Zhu Zongpeng , Xue Guangtao , Shu Jiwu , Li Minglu , Wu Jiesheng
Published: September 2023

The newly emerging “fail-slow” failures plague both software and hardware where the victim components are still functioning yet with degraded performance. To address this problem, this article presents
Perseus
, a practical fail-slow detection framework for storage devices.
Perseus
leverages a light regression-based model to quickly pinpoint and analyze fail-slow failures at the granularity of drives. Within a 10-month close monitoring on 248K drives,
Perseus
managed to find 304 fail-slow cases. Isolating them can reduce the (node-level) 99.99th tail latency by 48%. We assemble a large-scale fail-slow dataset (including 41K normal drives and 315 verified fail-slow drives) from our production traces, based on which we provide root cause analysis on fail-slow drives covering a variety of ill-implemented scheduling, hardware defects, and environmental factors. We have released the dataset to the public for fail-slow study.
GAGPT-2: A Geometric Attention-based GPT-2 Framework for Image Captioning in Hindi
Authors: Mishra Santosh Kumar , Chakraborty Soham , Saha Sriparna , Bhattacharyya Pushpak
Published: September 2023

Image captioning frameworks usually employ an encoder-decoder paradigm, with the encoder receiving abstract image feature vectors as input and the decoder for language modeling. Nowadays, most prominent architectures employ features from region proposals derived from object detection modules. In this work, we propose a novel architecture for image captioning. We employ the object detection module integrated with transformer architecture as an encoder and GPT-2 (Generative Pre-trained Transformer) as a decoder. The encoder utilizes the information of the spatial relationships among detected objects. We introduce a unique methodology for image caption generation in Hindi, which is widely spoken in South Asia and India and is the world’s third most spoken language as well as India’s official language. In terms of BLEU scores, the proposed approach’s performance is comparable to those of other baselines, and the results illustrate that the proposed approach outperforms the other baselines. The efficacy of the proposed approach in generating correct captions is further determined by human assessment in terms of adequacy and fluency.
A Comprehensive Survey on Model Quantization for Deep Neural Networks in Image Classification
Authors: Rokh Babak , Azarpeyvand Ali , Khanteymoori Alireza
Published: September 2023

Recent advancements in machine learning achieved by Deep Neural Networks (DNNs) have been significant. While demonstrating high accuracy, DNNs are associated with a huge number of parameters and computations, which leads to high memory usage and energy consumption. As a result, deploying DNNs on devices with constrained hardware resources poses significant challenges. To overcome this, various compression techniques have been widely employed to optimize DNN accelerators. A promising approach is quantization, in which the full-precision values are stored in low bit-width precision. Quantization not only reduces memory requirements but also replaces high-cost operations with low-cost ones. DNN quantization offers flexibility and efficiency in hardware design, making it a widely adopted technique in various methods. Since quantization has been extensively utilized in previous works, there is a need for an integrated report that provides an understanding, analysis, and comparison of different quantization approaches. Consequently, we present a comprehensive survey of quantization concepts and methods, with a focus on image classification. We describe clustering-based quantization methods and explore the use of a scale factor parameter for approximating full-precision values. Moreover, we thoroughly review the training of a quantized DNN, including the use of a straight-through estimator and quantization regularization. We explain the replacement of floating-point operations with low-cost bitwise operations in a quantized DNN and the sensitivity of different layers in quantization. Furthermore, we highlight the evaluation metrics for quantization methods and important benchmarks in the image classification task. We also present the accuracy of the state-of-the-art methods on CIFAR-10 and ImageNet. This article attempts to make the readers familiar with the basic and advanced concepts of quantization, introduce important works in DNN quantization, and highlight challenges for future research in this field.
Dynamic Weights and Prior Reward in Policy Fusion for Compound Agent Learning
Authors: Xu Meng , She Yechao , Jin Yang , Wang Jianping
Published: September 2023

In Deep Reinforcement Learning (DRL) domain, a compound learning task is often decomposed into several sub-tasks in a divide-and-conquer manner, each trained separately and then fused concurrently to achieve the original task, referred to as policy fusion. However, the state-of-the-art (SOTA) policy fusion methods treat the importance of sub-tasks equally throughout the task process, eliminating the possibility of the agent relying on different sub-tasks at various stages. To address this limitation, we propose a generic policy fusion approach, referred to as Policy Fusion Learning with Dynamic Weights and Prior Reward (PFLDWPR), to automate the time-varying selection of sub-tasks. Specifically, PFLDWPR produces a time-varying one-hot vector for sub-tasks to dynamically select a suitable sub-task and mask the rest throughout the entire task process, enabling the fused strategy to optimally guide the agent in executing the compound task. The sub-tasks with the dynamic one-hot vector are then aggregated to obtain the action policy for the original task. Moreover, we collect sub-tasks’s rewards at the pre-training stage as a prior reward, which, along with the current reward, is used to train the policy fusion network. Thus, this approach reduces fusion bias by leveraging prior experience. Experimental results under three popular learning tasks demonstrate that the proposed method significantly improves three SOTA policy fusion methods in terms of task duration, episode reward, and score difference.
Evaluating Long-Term Cycling Degradation in Cylindrical Li-Ion Batteries Using X-ray Tomography and Virtual Unrolling
Authors: Jnawali Anmol , Kok Matt D. R. , Krishna Muthu , Varnosfaderani Mina Abedi , Brett Daniel J. L. , Shearing Paul R.
Published: September 2023

Lithium-ion (Li-ion) batteries have undergone a multitude of improvements and achieved a high level of technological maturity. To further optimise cell performance, an understanding of the failure mechanisms is important. Forty-eight state-of-the-art cylindrical cells in the 21700 format, suitable for electric vehicles, are studied at the beginning-of-life (BOL) and end-of-life (EOL) by X-ray computed tomography (X-ray CT) and image analysis. The results indicate that shifting current collecting tabs closer to the centre of the cell and including a mandrel is likely to supress the propagation of capacity depleting deformations. It is recommended that manufacturers also try to improve cell assembly processes to form a more uniformly circular jelly roll and use tapered electrodes to minimise the nucleation of deformations.
Analysing Tortuosity for Solid Oxide Fuel Cell Anode Material: Experiments and Modeling
Authors: Zhang Xiaoqiang , Yang Danan , Xu Min , Naden Aaron , Espinoza-Andaluz Mayken , Li Tingshuai , Irvine John T. S. , Andersson Martin
Published: September 2023

Solid oxide fuel cells (SOFCs) directly convert chemical energy to electricity with high electrical efficiency. It involves gas transport through the porous electrode to the three-phase boundaries (TPB). The tortuosity of gas transport relates the bulk diffusion of gas in free space to the effective diffusion coefficient of gas migrating through a porous material. Therefore, determining the tortuosity is of great importance. This paper tests button SOFCs with NiO-YSZ as anode material followed by dual beam-focused ion beam scanning electron microscopy (FIB-SEM) to obtain 2D serial slice images. Based on processed 2D images and reconstructed 3D microstructure, the tortuosity is calculated using three approaches i.e., porosity-tortuosity correlations, voxel-based, and path-length-based approaches. The test results show that a decrease in Ni content in the anode greatly decreases the cell performance due to a decreased percolated electronic phase. The sample with low performance has high tortuosity. Different approaches vary regarding the tortuosity value and computational time. The path-length-based approach can achieve reasonable accuracy in a relatively short time but is only valid for using the longest path length.
A Dual Carbon Lithium-Ion Capacitor Using Recycled Polymer Separator Derived Carbon Cathode and Graphite Anode from Spent Lithium-Ion Battery
Authors: Bhattacharjee Udita , Bhar Madhushri , Ghosh Shuvajit , Bhowmik Subhajit , Martha Surendra K.
Published: September 2023

Lithium-ion capacitors (LICs) are hybrid capacitors that target pushing the energy limits of conventional supercapacitors by incorporating a lithium-ion battery (LIB)-type electrode without compromising much on the power density and cycle life of capacitors. Herein, a LIC is assembled using an ordered porous carbon cathode derived from the recycled polymer separator of spent LIBs and recycled graphite anode from the same source. The carbon-rich polymer is thermally stabilized and carbonized to utilize its porosity for ion storage and ordered matrix for better electronic conduction. The cathode half-cell delivers a capacitance of ∼100 F g−1 till 1000 cycles at 1 A g−1. In contrast, the anode half-cell delivers a capacity of 130 mAh g−1 under similar conditions. The assembled LIC provides an energy density of 129 Wh kg−1 at a power density of 275 W kg−1 and 54 Wh kg−1 at a high-power density of 13750 W kg−1. The LIC cycles with >70% capacitance retention till 6000 cycles. Further, the ion-storage mechanism of the LICs as well as their capacitive and diffusion-type contribution, is studied. The self-discharge and leakage current tests were performed in the cells to understand their practical feasibility.
Stacking Ni–Al and Co–Al Layered Double Hydroxide for High-Energy and High-Power Composite Electrodes
Authors: Hu Meng , Shen Shaodian
Published: September 2023

The requirement for high-power performance of secondary batteries suffering from inherent sluggish charge transfer kinetics is urgent for the expanding energy storage and conversion applications such as electric vehicles. A successful combination of high-power supercapacitors with high-energy secondary batteries in one energy storage device will meet the needs of both high power and energy density. We study the electrochemical behaviors of alternately stacked super-capacitive [Co4Al(OH)10]NO3 and [Ni4Al(OH)10]NO3 layered double hydroxide (LDH) electrodes. By cyclic voltammetry studies, the sandwich of [Co4Al(OH)10]NO3 lDH between [Ni4Al(OH)10]NO3 LDH and the Pt current collector results in the current amplification of the oxidation or reduction peaks to 4∼35 times. By galvanostatic charging/discharging, the 3-stacked Ni–Al|Co–Al|Ni–Al LDH electrode behaves better than the Co–Al|Ni–Al|Co–Al LDH electrode, exhibiting a maximal capacity, 338.1 mAh·g−1 under a current density of 1000 mA·g−1 and maintaining 288.6 mAh·g−1 within 400 cycles. It also has a much lower liquid-solid interface capacitor resistance and lower self-discharge. These results suggest that stacking in a suitable sequence contributes to high electrode performances, providing a strategy for producing energy storage and conversion devices. A synergetic charge transfer for the combination of Ni–Al and Co–Al LDH suggests that Co–Al LDH outstands as a bridge, accelerating the transfer of electrons.
Effect of the Cryogenically Treated Copper Nozzle Used in Plasma Arc Machining of S235 Steel
Authors: Senthilkumar N. , Jayaprakash G. , Nagaprasad N. , Ramaswamy Krishnaraj
Published: September 2023

The investigation was carried out by making use of the design of experiments method in order to achieve its objective, which was to study wear analysis in relation to a cryogenically treated nozzle that was utilized in plasma arc machining. Kerf width and surface roughness are two output characteristics that are key variables in deciding the quality of the cut and the efficiency of the operation. Both of these metrics are outputted by the process. While machining S235 steel, an investigation into the impact that nozzle treatment has on various quality metrics is currently under way. The examination is carried out with the arc voltage, the cutting speed, and the gas pressure, all serving as important components. A cryogenic treatment of the nozzle material using liquid nitrogen at a temperature of −194°C has been attempted in an effort to increase the life of the nozzle. Machining is performed using two different nozzle conditions, such as cryogenically treated and cryogenically untreated, with regard to the input parameter combinations that have been selected. To have a better understanding of the wear behavior of nozzles, an image from a scanning electron microscope is studied. Because of the treatment, the production of wear tracks in the direction that gas flow takes has been drastically decreased. This, in turn, has increased the cutting efficiency by decreasing the amount of arc current that was necessary. In addition, a grey relational analysis is carried out in order to find the best possible machining settings in both conditions. The parameters that were optimized for a nozzle that had been cryogenically treated were 6 bar of gas pressure, 120 amperes of arc current, and 1800 of cutting speed per minute. The use of cryogenic treatment resulted in a reduction of surface roughness by 0.4670 µm and a narrowing of the kerf width by 0.96 mm. It is clear from the SEM pictures of untreated and cryogenically treated nozzles that thermal distortion and wear in the nozzle tip area are minimized to a greater extent in the treated nozzle. This is evidenced by the fact that the treated nozzle has a more uniform appearance.
Cooperation Behavior of Opinion Leaders and Official Media on the Governance of Negative Public Opinion in the Context of the Epidemic: An Evolutionary Game Analysis in the Perspective of Prospect Theory
Authors: Wei Jing , Wang Lijun , Zhu Hengmin , Huang Weidong
Published: September 2023

The reach of online information transmission has expanded due to the rapid growth of social software and Internet technology, and the negative information generated during the COVID-19 outbreak can confuse the public. Therefore, a new challenge in the prevention and control of epidemics is how to supervise negative public perceptions. This study differentiates negative public opinion communication stages through practical cases and is based on the life cycle hypothesis. In order to examine the evolution and stability tactics of each game subject in each stage of the evolution of public opinion, a three-way evolution game model comprising social platform operators, official media, and opinion leaders is created on the basis of prospect theory. Finally, the advanced epidemic model is used to verify the important impact of cooperation between official media and opinion leaders on curbing the transmission of negative public opinion. It is found that the perceived value of game players on income and loss will significantly affect the trend of the tripartite game strategy, and the cooperative behavior of official media and opinion leaders can effectively promote the benign development of online public opinion.
The Use of Digital Media and Security Precautions in Adulthood
Authors: Haunschild Isabelle M. S. , Leipold Bernhard
Published: September 2023

The use of digital media through chatting, online conferencing, or browsing has become a leisure activity for many people, but it is not necessarily characterized by caution. Given the possibilities for misuse of data, the question of whether users actually implement security precautions and pay attention to protection of their data is important. The present study examines whether the use of digital media or security precautions is associated with age, commitment to technology (feelings of competence and control in dealing with technology), and flexible goal adjustment (the capacity to adjust personal goals in difficult life situations). In addition, we examine whether age differences in the use of social media (e.g., Facebook, WhatsApp, Telegram, Skype, and Zoom) are moderated by the commitment to technology and flexible goal adjustment. A total of 841 adults between 19 and 71 years of age (

M

age

=
43.57

;

SD
=
15.12

) participated in a cross-sectional questionnaire study. Age was positively correlated with security precautions but negatively with the use of social media. Security precautions and the use of digital social networks were correlated significantly with general flexibility of goal adjustment and technology commitment, even after age and gender were controlled with a structural equation model. Moderation analyses revealed that the relation between social media use and age was weaker among participants with higher degrees of technology commitment and flexible goal adjustment. We discuss the extent to which flexible goal adjustment and technology commitment can provide a mental precondition that promotes both digitized leisure activity and security precautions.
“You Sleep, You Die”: A Rare Clinical Case of Ondine’s Curse after Posterior Fossa Surgery
Authors: Karn Mitesh , Mahato Basant Kumar , Sah Ranjan , Kandel Dipendra , Sapkota Shabal
Published: September 2023

Ondine’s curse is a rare condition in which breathing is preserved while awake, but there is absence of autonomic control of ventilation. It is a potentially fatal complication that may result rarely from surgery in posterior fossa in area close to respiratory centers. We describe a patient with posterior fossa hemangioblastoma who underwent subtotal resection via telovelar approach and developed acquired Ondine’s curse postoperatively. The patient’s presentation and management are described. Besides that, Ondine’s is a great example of how modern medicine is linked to ancient literature, and thus, its anecdotal history is also described.
Evaluation of the Antitumor Effects of Platinum-Based [Pt(η1-C2H4-OR)(DMSO)(phen)]+ (R = Me, Et) Cationic Organometallic Complexes on Chemoresistant Pancreatic Cancer Cell Lines
Authors: Stefàno Erika , Cossa Luca Giulio , De Castro Federica , De Luca Erik , Vergaro Viviana , My Giulia , Rovito Gianluca , Migoni Danilo , Muscella Antonella , Marsigliante Santo , Benedetti Michele , Fanizzi Francesco Paolo
Published: September 2023

Pancreatic cancer is one of the most lethal malignancies with an increasing incidence and a high mortality rate, due to its rapid progression, invasiveness, and resistance to anticancer therapies. In this work, we evaluated the antiproliferative and antimigratory activities of the two organometallic compounds, [Pt(η1-C2H4-OMe)(DMSO)(phen)]Cl (1) and [Pt(η1-C2H4-OEt)(DMSO)(phen)]Cl (2), on three human pancreatic ductal adenocarcinoma cell lines with different sensitivity to cisplatin (Mia PaCa-2, PANC-1, and YAPC). The two cationic analogues showed superimposable antiproliferative effects on the tested cells, without significant differences depending on alkyl chain length (Me or Et). On the other hand, they demonstrated to be more effective than cisplatin, especially on YAPC cancer cells. For the interesting cytotoxic activity observed on YAPC, further biological assays were performed, on this cancer cell line, to evaluate the apoptotic and antimetastatic properties of the considered platinum compounds (1 and 2). The cytotoxicity of 1 and 2 compounds appeared to be related to their intracellular accumulation, which was much faster than that of cisplatin. Both 1 and 2 compounds significantly induced apoptosis and cell cycle arrest, with a high accumulation of sub-G1 phase cells, compared to cisplatin. Moreover, phenanthroline-containing complexes caused a rapid loss of mitochondria membrane potential, ΔΨM, if compared to cisplatin, probably due to their cationic and lipophilic properties. On 3D tumor spheroids, 1 and 2 significantly reduced migrated area more than cisplatin, confirming an antimetastatic ability.
Three Cases of Arteritic Anterior Optic Neuropathy Several Months after COVID-19 Vaccination
Authors: Yamamoto Yuichi , Ogino Ken , Yasuhara Satoshi , Kawashima Yu , Miki Toshiya
Published: September 2023

Background. Vaccines have been approved worldwide to control the coronavirus disease-19 (COVID-19). However, the postvaccination side effects remain controversial. Here, we describe three Japanese cases of arteritic anterior ischaemic optic neuropathy (AAION) following COVID-19 vaccination. Case presentation. The first case involved an 87-year-old woman who presented with vision loss in the right eye 2 months after her second COVID-19 vaccine and in the left eye 2 days later. The second case involved an 88-year-old woman who presented with vision loss in both eyes 3 months after receiving a second vaccine. The third case involved an 80-year-old man who presented with vision loss in the right eye 5 months after receiving a second vaccine. The C-reactive protein level and erythrocyte sedimentation rate were elevated in all patients. Biopsy of the temporal artery or auricular cartilage showed arteritic occlusion in case 2 and polychondritis in case 3. These patients were referred to a local Japanese hospital in 2021 over a period of no longer than 3 months. Conclusion. We observed three cases of AAION after the affected individuals received their second COVID-19 vaccine. Further long-term investigations of ophthalmological events after COVID-19 vaccination are warranted.
VISTA Expression on Cancer-Associated Endothelium Selectively Prevents T-cell Extravasation
Authors: Luk Sietse J. , Schoppmeyer Rouven , Ijsselsteijn Marieke E. , Somarakis Antonios , Acem Ibtissam , Remst Dennis F.G. , Cox Daan T. , van Bergen Cornelis A.M. , Briaire-de Bruijn Inge , Grönloh Max L.B. , van der Meer Werner J. , Hawinkels Lukas J.A.C. , Koning Roman I. , Bos Erik , Bovée Judith V.M.G. , de Miranda Noel F.C.C. , Szuhai Karoly , van Buul Jaap D. , Falkenburg J.H. Frederik , Heemskerk Mirjam H.M.
Published: September 2023

Cancers evade T-cell immunity by several mechanisms such as secretion of anti-inflammatory cytokines, down regulation of antigen presentation machinery, upregulation of immune checkpoint molecules, and exclusion of T cells from tumor tissues. The distribution and function of immune checkpoint molecules on tumor cells and tumor-infiltrating leukocytes is well established, but less is known about their impact on intratumoral endothelial cells. Here, we demonstrated that V-domain Ig suppressor of T-cell activation (VISTA), a PD-L1 homolog, was highly expressed on endothelial cells in synovial sarcoma, subsets of different carcinomas, and immune-privileged tissues. We created an ex vivo model of the human vasculature and demonstrated that expression of VISTA on endothelial cells selectively prevented T-cell transmigration over endothelial layers under physiologic flow conditions, whereas it does not affect migration of other immune cell types. Furthermore, endothelial VISTA correlated with reduced infiltration of T cells and poor prognosis in metastatic synovial sarcoma. In endothelial cells, we detected VISTA on the plasma membrane and in recycling endosomes, and its expression was upregulated by cancer cell–secreted factors in a VEGF-A–dependent manner. Our study reveals that endothelial VISTA is upregulated by cancer-secreted factors and that it regulates T-cell accessibility to cancer and healthy tissues. This newly identified mechanism should be considered when using immunotherapeutic approaches aimed at unleashing T cell–mediated cancer immunity.
Supplementary Figure 4 from Surgical Inflammation Alters Immune Response to Intraoperative Photodynamic Therapy
Authors: Davis Richard W. , Klampatsa Astero , Cramer Gwendolyn M. , Kim Michele M. , Miller Joann M. , Yuan Min , Houser Cassandra , Snyder Emma , Putt Mary , Vinogradov Sergei A. , Albelda Steven M. , Cengel Keith A. , Busch Theresa M.
Published: September 2023

Supplemental Figure 4. PDT response is not altered when it is followed by TI
TABLE 2 from Effect of Test History at Ages 50–64 on Later Cervical Cancer Risk: A Population-based Case–control Study
Authors: Kultalahti Henric , Heinävaara Sirpa , Sarkeala Tytti , Pankakoski Maiju
Published: September 2023

Characteristics of data
FIGURE 1 from Effect of Test History at Ages 50–64 on Later Cervical Cancer Risk: A Population-based Case–control Study
Authors: Kultalahti Henric , Heinävaara Sirpa , Sarkeala Tytti , Pankakoski Maiju
Published: September 2023

Lexis chart describing the data. The study period was 2000–2019, and the subjects were born between 1940 and 1954. The diagram shows the years when each cohort was invited to screening. Those born between 1950 and 1954 were invited to screening three times but had the shortest period of surveillance data. Those born between 1940–1944 had only one invitation to the screening program but had extensive cancer surveillance data. The figure is not indicative of the real data, but merely illustrates when testing in and outside the program can occur.
HER2-Selective and Reversible Tyrosine Kinase Inhibitor Tucatinib Potentiates the Activity of T-DM1 in Preclinical Models of HER2-positive Breast Cancer
Authors: Olson Devra , Taylor Janelle , Willis Kelsi , Hensley Kelly , Allred Sean , Zaval Margo , Farr Lauren , Thurman Robert , Jain Nishi , Hein Renee , Ulrich Michelle , Peterson Scott , Kulukian Anita
Published: September 2023

The oncogenic receptor HER2 is overexpressed in many cancers, including up to 20% of breast cancers. Despite the availability of HER2-targeted treatments, patients’ disease often progresses during therapy, underscoring the need for novel treatment strategies. The addition of tucatinib, a reversible, highly selective HER2 tyrosine kinase inhibitor (TKI), to treatment with trastuzumab and capecitabine significantly improved survival outcomes of patients with HER2-positive metastatic breast cancer, including those with active brain metastases. We rationalized that combining tucatinib with other HER2-targeting agents with complementary mechanisms of action would further increase efficacy against tumors. We characterized the activity of tucatinib with the antibody–drug conjugate T-DM1 in preclinical models of breast cancer, including HER2-positive breast cancer cells and patient-derived xenograft (PDX) models. Mechanistic details on tucatinib activity were obtained in internalization and catabolism studies. In combination, tucatinib and T-DM1 showed an enhanced, often synergistic, cytotoxic response and demonstrated improved antitumor activity in vivo, including in PDX models refractory to T-DM1 single-agent activity. Mechanistically, tucatinib mediated an increase in inactive HER2 molecules at the cell surface through inhibition of HER2 ubiquitination, resulting in increased internalization and catabolism of T-DM1. The combination was correlated with enhanced HER2 pathway inhibition, decreased proliferation, and increased apoptosis. In a xenograft model of brain metastasis, tucatinib penetrated intracranial tumor tissues, inhibiting tumor growth and improving survival. These results suggest that tucatinib may be the optimal TKI partner for HER2-targeted therapies and support clinical studies of its combination with T-DM1, including in patients with brain metastases.

Significance:

The preclinical findings in breast cancer models presented here demonstrate that combining tucatinib with T-DM1 enhances the antitumor activity of either agent alone, supporting clinical studies of the combination in HER2-positive breast cancer, including in patients with brain metastases, which remains an important unmet medical need.
Estados recusados: o efeito do culturalismo em nações com histórico de colonização
Authors: Zocca Ricardo , Martins Moisés de Lemos
Published: September 2023

Este estudo analisa a formação de Estados de minorias com Deleuze & Guattari (1997), o efeito do culturalismo em nações com histórico de colonização proposto por Souza (2019), além da influência que o sistema econômico tem nesse processo com Mandel (1998), atuando também como agente de pureza de Bauman (1998). A culminação desse processo divide os países e as populações em duas castas, a elite europeizada e o populacho, num movimento que se espiraliza e se retroalimenta. A elite se enxerga como distante da população e ocupa os principais cargos de informação no país, alastrando o culturalismo para todas as camadas da população.
A mobilizacão de afetos nas finanças: humor, fracasso e discurso neoliberal nas páginas Faria Lima Elevator e Investidor da Depressão
Authors: Casadei Eliza Bachega
Published: September 2023

Posto que os imperativos da financeirização demandam engajamento afetivo dos indivíduos aos produtos, o objetivo deste artigo é analisar as convocações midiáticas ao consumo operacionalizadas por perfis de Instagram de finanças que apelam ao humor. Recorremos ao método da Análise de Discurso de linha francesa para estudar alguns cruzamentos entre discursos nessas convocações midiáticas. Embora seus conteúdos pareçam caçoar de alguns lugares comuns da literatura de autoajuda financeira, há um aparato discursivo que legitima a norma ao contradizê-la. Trata-se de produções que, a partir do humor, validam certos tipos de comportamento em relação às finanças e constroem, através do discurso, um tipo de consumidor específico, ao naturalizar práticas e legitimar comportamentos vinculados à financeirização das relações econômicas a partir da comunicação.
Cildo Meireles e a reforma do zero da economia
Authors: Hermann Victor
Published: September 2023

O sistema monetário internacional deve passar por transformações radicais em virtude da concorrência de moedas digitais e da emergência de uma nova ordem multipolar. Em busca de propor um conceito alternativo de dinheiro, neste artigo revisitaremos as obras de Cildo Meireles que versam sobre o dinheiro, especialmente Zero Dólar (1978-1984), Zero Cruzeiro (1974) e Zero Real (2013), todas pertencentes ao projeto Inserções em circuitos  antropológicos. O artista propõe uma reforma “do zero” da economia, em que são questionadas as relações entre moeda e matéria, entre confiança e reputação, entre criação e circulação de valor. Trata-se de uma utopia das trocas monetárias, irredutível à tirania financeira da especulação e do endividamento.
Processos de criação em arte generativa como metodologia de atravessamento: pesquisa colaborativa transdisciplinar com comunidades Guarani e Kaiowá
Authors: Montanari Matheus da Rocha , Sordi Caetano
Published: September 2023

Neste artigo, apresentamos a pesquisa artística, em particular os processos de criação em arte generativa, como forma viável de conduzir projetos interdisciplinares e colaborativos. No contexto do projeto Ecologias do Pensamento, parte do Museu Virtual Guarani e Kaiowá, argumentamos que, a partir da criação artística, é possível instaurar um espaço de atravessamento entre diferentes maneiras de pensar e produzir conhecimento, revendo questões ontológicas da tecnologia. Com base no conceito de cosmotécnica, e nas relações cosmológicas indígenas entre plantas e sons, discutiremos a produção de experimentos artísticos generativos em realidade virtual, destacando como a criação artística pode desenvolver um papel ativo de pesquisa, ultrapassando representações ou ilustrações de uma forma de conhecimento/existência em direção a outra.
Presença de Frege na filosofia da arte de Arthur Danto
Authors: Bogéa Anderson
Published: September 2023

O presente estudo tem por objetivo identificar a presença de Gottlob Frege na filosofia da arte de Arthur C. Danto. Partimos do pressuposto de que algumas das principais soluções teóricas encontradas por Danto têm por base e inspiração a semântica fregeana. Para isso, analisamos o corpus em filosofia da arte de Danto, e mapeamos as passagens mais características do fenômeno observado, correlacionando com alguns trechos da obra de Frege.
Dialética entre os sentidos positivo e negativo da dessacralização da arte
Authors: Guimarães Bruno
Published: September 2023

Assimilando a visão dialética de Adorno sobre o tema da perda da aura em Benjamin, pensado como uma “tendência evolutiva” da desartificação da arte, mas também como uma tendência a transformar a arte em indústria cultural, quando manejada a-dialeticamente, este artigo pretende analisar as consequências da dessacralização da arte. O objetivo é indicar a contrapartida positiva ligada à perda de autenticidade e valor de culto na arte, levando em conta a presença dos conceitos de “mimesis” e “jogo” na segunda versão de A obra de arte na era da reprodutibilidade técnica e examinar algumas possíveis consequências desses efeitos dessacralizantes no campo sociopolítico.
Arquitetura reflexiva entre expressão e desenho na estética de Kant
Authors: Gally Miguel
Published: September 2023

Este artigo pretende expor e ampliar de que modo a arquitetura bela ou reflexiva pensada por Immanuel Kant inclui uma crítica à tradição vitruviana. Partindo das interpretações de Paul Guyer (1977, 2011) sobre um sentido de expressão e do lugar histórico assumido por Kant na filosofia da arquitetura, tentaremos incluir nesse debate a importância teórica do projeto arquitetônico (desenho), visando, com isso, uma compreensão mais ampla da arquitetura reflexiva.
Os pássaros e o vírus: Hitchcock na pandemia
Authors: Duarte Pedro
Published: September 2023

O que o grande cineasta Hitchcock tem a nos dizer sobre a pandemia que vivemos? Como a Covid-19 abriu uma possibilidade de assistir ao filme Os pássaros que não era evidente em sua época? Nessa via de mão-dupla, é como se Hitchcock pudesse nos ajudar a pensar a pandemia atual, mas apenas porque ela permitiu enxergar algo novo em Os pássaros. É o caso de pensar o que elementos da natureza não-humana, sejam pássaros ou vírus, dizem sobre o antropocentrismo da civilização moderna.
Gender bias in funding evaluation: A randomized
experiment
Authors: Cruz-Castro Laura , Sanz-Menéndez Luis
Published: September 2023

Gender differences in research funding exist, but bias evidence is elusive and findings are contradictory. Bias has multiple dimensions, but in evaluation processes, bias would be the outcome of the reviewers’ assessment. Evidence in observational approaches is often based either on outcome distributions or on modeling bias as the residual. Causal claims are usually mixed with simple statistical associations. In this paper we use an experimental design to measure the effects of a cause: the effect of the gender of the principal investigator (PI) on the score of a research funding application (treatment). We embedded a hypothetical research application description in a field experiment. The subjects were the reviewers selected by a funding agency, and the experiment was implemented simultaneously with the funding call’s peer review assessment. We manipulated the application item that described the gender of the PI, with two designations: female PI and male PI. Treatment was randomly allocated with block assignment, and the response rate was 100% of the population, avoiding problems of biased estimates in pooled data. Contrary to some research, we find no evidence that male or female PIs received significantly different scores, nor any evidence of same-gender preferences of reviewers regarding the applicants’ gender.
Evaluation of Long-Term Nutrition Outcomes After Duodenal Switch: A Systematic Review and Meta-Analysis
Authors: Nakanishi Hayato , Abi Mosleh Kamal , AL-Kordi Mohammad , Marrero Katie , Kermansaravi Mohammad , Davis S. Scott , Clapp Benjamin , Ghanem Omar M.
Published: September 2023

Background

Biliopancreatic diversion with duodenal switch (BPD-DS) is the most effective and durable metabolic and bariatric surgery to achieve a target weight loss. However, many surgeons are hesitant to adopt BPD-DS due to a lack of training, technical complexity, and long-term nutrition deficiencies. This meta-analysis aimed to investigate long-term nutrition outcomes after primary BPD-DS in the management of obesity.

Methods

Cochrane, Embase, PubMed, Scopus, and Web of Science were searched for articles from their inception to February 2023 by 2 independent reviewers using the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) system. The review was registered prospectively with PROSPERO (CRD42023391316).

Results

From 834 studies screened, 8 studies met the eligibility criteria, with a total of 3443 patients with obesity undergoing primary BPD-DS. At long-term follow-up (≥5 years), 25.4% of patients had vitamin A deficiency (95% CI: -.012, .520, I2 = 94%), and 57.3% had vitamin D deficiency (95% CI: .059, 1.086, I2 = 86%). Calcium deficiency was observed in 125 patients (22.2%, 95% CI: .061, .383, I2 = 97%), and 69.7% had an abnormal parathyroid hormone level (95% CI: .548, .847, I2 = 78%). Ferritin level was abnormal in 30 patients (29.0%, 95% CI: .099, .481, I2 = 79%).

Conclusions

Despite displaying comparable nutrition-related outcomes to mid-term follow-up, our study demonstrated that BPD-DS could result in a high level of long-term nutrition deficiency after BPD-DS for selected patients. However, further randomized controlled studies with standardized supplementation regimens and improvement in compliance are necessary to evaluate and prevent long-term nutritional deficiencies after BPD-DS.