bluuebunny/crossref_metadata_2025 huggingface dataset:
Multi-order hypergraph convolutional networks integrated with self-supervised learning
Authors: Huang Jiahao , Lei Fangyuan , Jiang Jianjian , Zeng Xi , Ma Ruijun , Dai Qingyun
Published: January 2023

Hypergraphs, as a powerful representation of information, effectively and naturally depict complex and non-pair-wise relationships in the real world. Hypergraph representation learning is useful for exploring complex relationships implicit in hypergraphs. However, most methods focus on the 1-order neighborhoods and ignore the higher order neighborhood relationships among data on the hypergraph structure. These often result in underutilization of hypergraph structure. In this paper, we exploit the potential of higher order neighborhoods in hypergraphs for representation and propose a Multi-Order Hypergraph Convolutional Network Integrated with Self-supervised Learning. We first encode the multi-channel network of the hypergraph by a high-order spectral convolution operator that captures the multi-order representation of nodes. Then, we introduce an inter-order attention mechanism to preserve the low-order neighborhood information. Finally, to extract valid embedding in the higher order neighborhoods, we incorporate a self-supervised learning strategy based on maximizing mutual information in the multi-order hypergraph convolutional network. Experiments on several hypergraph datasets show that the proposed model is competitive with state-of-the-art baselines, and ablation studies show the effectiveness of higher order neighborhood development, the inter-order attention mechanism, and the self-supervised learning strategy.
Structure and Content of BEng Chemical Engineering Programmes in the UK, Relative to the Frontiers in Chemical Engineering Education Model
Authors: Bilques Zakia , Belton Daniel J. , Campbell Grant M.
Published: January 2023

TheFrontiers in Chemical Engineering Educationinitiative in the USA in the early 2000s proposed a reformed chemical engineering curriculum organised around the three themes ofMolecular transformations,Multiscale analysisand aSystemsview. It was subsequently observed that few departments in the USA had adopted this structure for their programmes, although several UK programmes appeared already to feature this structure. Therefore, the objective of the current work was to analyse BEng chemical engineering programmes in the UK relative to this tripartite structure, in order to evaluate to what extent theFrontiersmodel was already represented within UK chemical engineering education. From the 28 UK universities offering IChemE-accredited programmes, the structure and content of 24 BEng programmes were analysed against the tripartiteFrontiersstructure. All 24 programmes broadly followed theFrontiersstructure. The greatest variation between programmes was in the amount of content contributing to theMolecular transformationstheme, which varied from 1.4 to 26%. This was also the smallest of the three themes, contributing on average around 10%, compared with 37% forMultiscale analysisand 38% forSystems, with 10% coming fromSupporting Competences(such as laboratory and professional skills) and 5% fromOthersubjects (such as mechanical or electrical engineering or electives).Molecular transformationswas generally most prominent in the first year, the second year tended to contribute the mostMultiscale analysiscontent and the final year was dominated bySystems. The Institution of Chemical Engineers’ Accreditation guidance tends to encourage the highSystemsemphasis and lowMolecular transformationscomponent, in contradiction to the recommendations of theFrontiersinitiative. Optional electives and MEng specialisms featureMolecular transformationsemphases, the latter less so than in the 2000s, since when the drivers for curriculum development have moved from biosciences and nanotechnology towards energy and sustainability.
Artificial moral experts: asking for ethical advice to artificial intelligent assistants
Authors: Rodríguez-López Blanca , Rueda Jon
Published: January 2023

In most domains of human life, we are willing to accept that there are experts with greater knowledge and competencies that distinguish them from non-experts or laypeople. Despite this fact, the very recognition of expertise curiously becomes more controversial in the case of “moral experts”. Do moral experts exist? And, if they indeed do, are there ethical reasons for us to follow their advice? Likewise, can emerging technological developments broaden our very concept of moral expertise? In this article, we begin by arguing that the objections that have tried to deny the existence (and convenience) of moral expertise are unsatisfactory. After that, we show that people have ethical reasons to ask for a piece of moral advice in daily life situations. Then, we argue that some Artificial Intelligence (AI) systems can play an increasing role in human morality by becoming moral experts. Some AI-based moral assistants can qualify as artificial moral experts and we would have good ethical reasons to use them.
A prospective cohort study of depression (PROUD) in China: rationale and design
Authors: Zhou Jingjing , Xu Jinjie , Liu Rui , Qi Han , Yang Jian , Guo Tong , Zhou Jia , Zhu Xuequan , Zhang Ling , Chen Xiongying , Lyu Nan , Feng Zizhao , Zhang Guofu , Liu Min , Wang Weiwei , Wang Yun , Zhang Zhifang , Xiao Le , Feng Yuan , Wang Gang
Published: January 2023

Background

Major depressive disorder (MDD) imposes a heavy global disease burden. However, current etiology, diagnosis and treatment remain unsatisfactory and no previous study has resolved this problem. Building on the strengths and limitations of previous cohort studies of MDD, the prospective cohort study of depression (PROUD) is a 3-year large-scale cohort study designed to collect multidimensional data with a flexible follow-up schedule and strategy. The goal is to establish a nationally representative, high-quality, standardized depression cohort to support precise diagnosis and treatment of MDD and address the gap in current research.

Methods

PROUD is a patient-based, nationally representative multicenter prospective cohort study with baseline and 3-year follow-up assessments. It will be carried out from January 2022 to December 2026 in 52 qualified tertiary hospitals in China. A total of 14,000 patients diagnosed with MDD, according to the DSM-5 criteria, and aged ≥ 16 years, will be recruited to PROUD. Participants aged 18-65 years who have not received any treatment during a depressive episode will be included in the precision medicine cohort (PMC) of PROUD (n=4,000). Patients who meet the general eligibility criteria but not the PMC criteria will be included in the naturalistic observation cohort (NOC) of PROUD (n=10,000). A multiple follow-up strategy, including scheduled, remote, telephone, external visits and patient self-reports, will be implemented to collect comprehensive sociodemographic, clinical information, biospecimens, neuroimaging, cognitive function and electrophysiology data and digital phenotypes according to strict standard operating procedures implemented across centers. Trial registration: ChiCTR2200059053, registered on 23 April 2022, http://www.chictr.org.cn/showproj.aspx?proj=165790.

Conclusions

PROUD is a prospective cohort study of MDD patients in China. It will provide a comprehensive database facilitating further analyses and aiding the development of homeostatic and precision medicine in China.
Understanding the epidemiology and impact of the COVID-19 pandemic on domestic violence and child abuse in Saudi Arabia
Authors: Alkhattabi Fadiah , Al Faryan Nawaf , Alsaleh Manar , Long Maureen , Alkhani Abdullah , Alwahibah Salma , Frederico Margarita , Alhuthil Raghad
Published: January 2023

Objectives:

The purpose of this paper is to highlight the impact of a pandemic on the lives of vulnerable members of the community who have experienced or are 'at risk' of experiencing intimate family violence and child abuse in Saudi Arabia. By reviewing the experience in Saudi Arabia in the context of the international literature, the study explores similarities and differences in the impact of the pandemic on family violence.

Methods:

The study investigated the impact of the COVID-19 pandemic on family violence and child abuse in Saudi Arabia by conducting a comparative analysis of the prevalence of cases, types of abuse, and geographical location of those experiencing violence between the years 2019 and 2020. Data were obtained from the Family Violence Reporting Center 1919 in Saudi Arabia.

Results:

The study found that the risk of family violence and child abuse increased during the COVID-19 pandemic in Saudi Arabia, similar to findings in other countries. Conversely, there was a decrease in the number of reports due to factors associated with COVID-19.

Conclusions:

The study highlighted the importance of ensuring that existing policies and services are sufficient to ensure the risks arising from the impact of COVID-19 responses and minimize the negative consequences.
The forgotten preconditions for a well-functioning internet
Authors: Goodell Geoffrey
Published: January 2023

For decades, proponents of the Internet have promised that it would one day provide a seamless way for everyone in the world to communicate with each other, without introducing new boundaries, gatekeepers, or power structures. What happened? This article explores the system-level characteristics of a key design feature of the Internet that helped it to achieve widespread adoption, as well as the system-level implications of certain patterns of use that have emerged over the years as a result of that feature. Such patterns include the system-level acceptance of particular authorities, mechanisms that promote and enforce the concentration of power, and network effects that implicitly penalize those who do not comply with decisions taken by privileged actors. We provide examples of these patterns and offer some key observations, toward the development of a general theory of why they emerged despite our best efforts, and we conclude with some suggestions on how we might mitigate the worst outcomes and avoid similar experiences in the future.
Lactate, histone lactylation and cancer hallmarks
Authors: Lv Xinyu , Lv Yingying , Dai Xiaofeng
Published: January 2023

Histone lactylation, an indicator of lactate level and glycolysis, has intrinsic connections with cell metabolism that represents a novel epigenetic code affecting the fate of cells including carcinogenesis. Through delineating the relationship between histone lactylation and cancer hallmarks, we propose histone lactylation as a novel epigenetic code priming cells toward the malignant state, and advocate the importance of identifying novel therapeutic strategies or dual-targeting modalities against lactylation toward effective cancer control. This review underpins important yet less-studied area in histone lactylation, and sheds insights on its clinical impact as well as possible therapeutic tools targeting lactylation.
Asiatic dayflower (Commelina communis) control in Douglas fir
Authors: Aulakh Jatinder S.
Published: January 2023

Asiatic dayflower (Commelina communis L.) is becoming increasingly invasive in Christmas tree plantations in the U.S. Northeast. Response of C. communis to preemergence or postemergence herbicides was evaluated in separate field and greenhouse experiments. The preemergence herbicides consisted of two application rates of flumioxazin (215 and 429 g ai ha−1), hexazinone plus sulfometuron-methyl (316 and 527 g ai ha−1), indaziflam (41 and 82 g ai ha−1), and S-metolachlor (2,136 and 4,272 g ai ha−1). The postemergence herbicides were: bentazon at 1,121 g ai ha−1, clopyralid at 280 g ae ha−1, mesotrione at 526 g ai ha−1, topramezone at 294 g ai ha−1, and triclopyr at 842 g ae ha−1. At 16 wk after treatment, higher rates of flumioxazin (429 g ha−1), hexazinone plus sulfometuron-methyl (527 g ha−1), indaziflam (82 g ha−1), and S-metolachlor (4,272 ha−1) provided 80% to 92% control and reduced C. communis plant density by 84% to 93% compared with the nontreated control. The lower rates of flumioxazin (215 g ha−1), hexazinone plus sulfometuron-methyl (316 g ha−1), and S-metolachlor (2,136 ha−1) gave 65% to 72% control and reduced C. communis plant density by 27% to 75% compared with the nontreated control. The postemergence application of mesotrione at 526 g ha−1, topramezone at 294 g ha−1, and triclopyr at 842 g ha−1 resulted in 76% to 90% control and reduction in dry biomass of 10- to 12-leaf C. communis at 28 d after treatment. Bentazon at 1,121 g ha−1 and clopyralid at 280 g ha−1 applied postemergence were ineffective with <10% control and reduction in C. communis dry biomass. This study showed that C. communis can be managed effectively with currently registered preemergence and postemergence herbicides in Christmas trees.
Drifting toward Revolution: Kurt Scharf and the dah shab in Tehran
Authors: Gölz Olmo
Published: January 2023

Poetry readings are an intimate affair; they are not suitable for mobilizing the masses. But poems can capture moods and trigger emotions. They can create closeness and community, send messages and demand change. Indeed, in the case of Iran, a series of poetry reading sessions can be considered a milestone event on the country's path toward revolution.2 During ten nights of poetry reading, known as the dah shab, in October 1977 in Tehran, the country's most prominent poets and writers took advantage of a short window of opportunity that opened up for them when the Shah loosened somewhat the reins of dictatorship. Beginning on October 10, 1977, they presented their poems to thousands of listeners on ten consecutive evenings on the premises of the German-Iranian Cultural Association on Pahlavī Avenue. Poets of all political persuasions were present, united above all in their common interest of demanding an end to censorship and standing up for freedom of speech. The impressive list of participants includes such well-known names as Behazin, Simin Behbehani, Mehdi Akhavan-Sales, Houshang Golshiri, Saeed Soltanpour, and Siavosh Kasrai, along with many more.3
Unsteadiness characterisation of shock wave/turbulent boundary-layer interaction at moderate Reynolds number
Authors: Bernardini Matteo , Della Posta Giacomo , Salvadore Francesco , Martelli Emanuele
Published: January 2023

A direct numerical simulation of an oblique shock wave impinging on a turbulent boundary layer at Mach number 2.28 is carried out at moderate Reynolds number, simulating flow conditions similar to those of the experiment by Dupont et al. (J. Fluid Mech., vol. 559, 2006, pp. 255–277). The low-frequency shock unsteadiness, whose characteristics have been the focus of considerable research efforts, is here investigated via the Morlet wavelet transform. Owing to its compact support in both physical and Fourier spaces, the wavelet transformation makes it possible to track the time evolution of the various scales of the wall-pressure fluctuations. This property also makes it possible to define a local intermittency measure, representing a frequency-dependent flatness factor, to pinpoint the bursts of energy that characterise the shock intermittency scale by scale. As a major result, wavelet decomposition shows that the broadband shock movement is actually the result of a collection of sparse events in time, each characterised by its own temporal scale. This feature is hidden by the classical Fourier analysis, which can only show the time-averaged behaviour. Then, we propose a procedure to process any relevant time series, such as the time history of the wall pressure or that of the separation bubble extent, in which we use a condition based on the local intermittency measure to filter out the turbulent content in the proximity of the shock foot and to isolate only the intermittent component of the signal. In addition, wavelet analysis reveals the intermittent behaviour also of the breathing motion of the recirculation bubble behind the reflected shock, and allows us to detect a direct, partial correspondence between the most significant intermittent events of the separation region and those of the wall pressure at the foot of the shock.
Linking host plants to damage types in the fossil record of insect herbivory
Authors: Schachat Sandra R. , Payne Jonathan L. , Boyce C. Kevin
Published: January 2023

Studies of insect herbivory on fossilized leaves tend to focus on a few, relatively simple metrics that are agnostic to the distribution of insect damage types among host plants. More complex metrics that link particular damage types to particular host plants have the potential to address additional ecological questions, but such metrics can be biased by sampling incompleteness due to the difficulty of distinguishing the true absence of a particular interaction from the failure to detect it—a challenge that has been raised in the ecological literature. We evaluate a range of methods for characterizing the relationships between damage types and host plants by performing resampling and subsampling exercises on a variety of datasets. We found that the components of beta diversity provide a more valid, reliable, and interpretable method for comparing component communities than do bipartite network metrics and that the rarefaction of interactions represent a valid, reliable, and interpretable method for comparing compound communities. Both beta diversity and rarefaction of interactions avoid the potential pitfalls of multiple comparisons. Finally, we found that the host specificity of individual damage types is challenging to assess. Whereas bipartite network metrics are sufficiently biased by sampling incompleteness to be inappropriate for fossil herbivory data, alternatives exist that are perfectly suitable for fossil datasets with sufficient sample coverage.
Stabilizing History through Statues, Monuments, and Memorials in Curzon's India
Authors: Ghosh Durba
Published: January 2023

This article argues that projects to make Britain's imperial history visible to the public through the display of statues, the establishment of a history museum, and the renovation of historical markers solidified a colonial narrative about the British empire's permanence in India during the first two decades of the twentieth century, decades in which anticolonial unrest threatened the British occupation of the subcontinent. The monumental scale expressed permanence. An imperial aesthetic linked the cities important to showcasing the empire in Calcutta, New Delhi, and London. Contrary to mainstream assumptions that commemorations should be preserved for the sake of documenting history, these markers enacted a British story of triumph at a moment when mass campaigns against British rule were occurring. Coming at the end of a long nineteenth century of statue mania, when many European nations installed memorials to national heroes, the installation of monuments in India presented a colonialist public history of events such as the Black Hole incident of 1757 or the rebellions of 1857. Drawing from Viceroy George Curzon's ambitions in historical preservation and monumentalizing, the article shows how he stabilized a British narrative of India amid anticolonial campaigns of protest.
Community-dwelling older adults' experiences and perceptions of needs for home modification in Shanghai
Authors: Chen Lin , Mao Xupeng , Kahana Eva , Chen Sangyi
Published: January 2023

Home environment is essential to older adults. While existing studies have investigated the positive implications of home modification strategies for older adults and proposed relevant policies and programmes, literature has remained relatively silent on how older adults perceive their needs for their home environment and its modification, especially during and after they go through home modification projects. This study investigated community-dwelling older adults' perceptions of needs for home modification in Shanghai. Informed by theories in environmental gerontology and tenets of awareness of age-related change, we conceptualised two intertwined, evolving processes of person–environment (P-E) interactions: older adults' interactions with their home environment, and the interactions between their perceptions of needs for home modification and the ageing process. Taking a qualitative approach, we interviewed community-dwelling older adults who were among the first to have received a pilot government-sponsored home modification project in Shanghai (N = 15). Our findings suggest that older adults' P-E dynamics evolved in response to their perception of their home environment and ageing process. Most participants initially were unaware of their underlying needs for home modification even when they had encountered challenges in their apartments. As the home modification project took place, participants gradually gained knowledge of their home environment and the following modification, which enabled them to better identify and articulate their needs to improve their daily living. After the project, participants' understandings of their home environments continued to evolve, expanding to their neighbourhood. This study informs policy and practice to focus on recognising the evolving aspects of older adults' needs in their home environment and better engaging older adults in the process of home modification.
On the dual risk model with Parisian implementation delays under a mixed dividend strategy
Authors: Hu Kang , Li Jingchao , Zhou Jieming
Published: January 2023

In this paper, we consider a mixed dividend strategy in a dual risk model. The mixed dividend strategy is the combination of a threshold dividend and a Parisian implementation delays dividend under periodic observation. Given a series of discrete observation points, when the surplus level is larger than the predetermined bonus barrier at observation point, the Parisian implementation delays dividend is immediately carried out, and the threshold dividend is performed continuously during the delayed period. We study the Gerber-Shiu expected discounted penalty function and the expected discounted dividend payments before ruin in such a dual risk model. Numerical illustrations are given to study the influence of relevant parameters on the ruin-related quantities and the selection of the optimal dividend barrier for a given initial surplus level.
Detection of aberrant DNA methylation patterns in sperm of male recurrent spontaneous abortion patients
Authors: Ma Rong-Hua , Zhang Zhen-Gang , Zhang Yong-Tian , Jian Sheng-Yan , Li Bin-Ye
Published: January 2023

Aberrant DNA methylation patterns in sperm are a cause of embryonic failure and infertility, and could be a critical factor contributing to male recurrent spontaneous abortion (RSA). The purpose of this study was to reveal the potential effects of sperm DNA methylation levels in patients with male RSA. We compared sperm samples collected from fertile men and oligoasthenospermia patients. Differentially methylated sequences were identified by reduced representation bisulfite sequencing (RRBS) methods. The DNA methylation levels of the two groups were compared and qRT-PCR was used to validate the expression of genes showing differential methylation. The results indicated that no difference in base distribution was observed between the normal group and the patient group. However, the chromosome methylation in these two groups was markedly different. One site was located on chromosome 8 and measured 150 bp, while the other sites were on chromosomes 9, 10, and X and measured 135 bp, 68 bp, and 136 bp, respectively. In particular, two genes were found to be hypermethylated in these patients, one gene was DYDC2 (placed in the differential methylation region of chromosome 10), and the other gene was NXF3 (located on chromosome X). Expression levels of DYDC2 and NXF3 in the RSA group were significantly lower than those in the normal group (P < 0.05). Collectively, these results demonstrated that changes in DNA methylation might be related to male RSA. Our findings provide important information regarding the potential role of sperm DNA methylation in human development.
Monetary policy transmission in China: dual shocks with dual bond markets
Authors: El-Shagi Makram , Jiang Lunan
Published: January 2023

Although China’s monetary and financial system differs drastically from its Western counterpart, empirical studies covering this vast economy have often been simple reestimations or recalibrations of models originally designed to describe US or European monetary policy. In this paper, we aim to assess Chinese monetary policy and, in particular, monetary policy transmission through yield curves into the real economy. Our study takes into account the peculiarities of the Chinese economy: Namely, our model includes both China’s modern attempts at a market-based monetary policy as well as the “authority-based” one that is a relic of the original banking system. Besides, it considers the special nature of the Chinese treasury bond market, which is separated into two independent ones with very limited direct arbitrage opportunities between almost identical assets. Finally, it incorporates the role of real estate, which played an essential role in China during the last decade. Our results show that different monetary policy shocks cause asymmetric effects on macroeconomic and financial variables.
Visible to Near‐Infrared Reflectance Spectroscopy of Asteroid (16) Psyche: Implications for the Psyche Mission's Science Investigations
Authors: Dibb S. D. , Bell J. F. , Elkins‐Tanton L. T. , Williams D. A.
Published: January 2023

The NASA Psyche mission will explore the structure, composition, and other properties of asteroid (16) Psyche to test hypotheses about its formation. Variations in radar reflectivity, density, thermal inertia, and visible to near‐infrared (VNIR) reflectance spectra of Psyche suggest a highly metallic composition with mafic silicate minerals (e.g., pyroxene) heterogeneously distributed on the surface in low abundance (<10 vol.%). The Psyche spacecraft's Multispectral Imager is designed to map ≥80% of the surface at high spatial resolution (≤20 m/pixel) through a panchromatic filter and provide compositional information for about ≥80% of the surface using seven narrowband filters at VNIR wavelengths (∼400–1,100 nm) and at spatial scales of ≤500 m/pixel. We analyzed 359 reflectance spectra from samples consistent with current uncertainties in Psyche's composition and compared them to published reflectance spectra of the asteroid using a chi‐square test for goodness of fit. The best matches for Psyche include iron meteorite powder, powders from the sulfide minerals troilite and pentlandite, and powder from the CH/CBb chondrite Isheyevo. Comparison of absorption features support the interpretation that Psyche's surface is a metal‐silicate mixture, although the exact abundance and chemistry of the silicate component remains poorly constrained. We convolve our spectra to the Imager's spectral throughput to demonstrate preliminary strategies for mapping the surface composition of the asteroid using filter ratios and reconstructed band parameters. Our results provide predictions of the kinds of surface compositional information that the Psyche mission could reveal on the solar system's largest M‐type asteroid.
The Increasing Efficiency of the Poleward Energy Transport Into the Arctic in a Warming Climate
Authors: Cardinale Christopher J. , Rose Brian E. J.
Published: January 2023

This study quantifies the contribution to Arctic winter surface warming from changes in the tropospheric energy transport (Ftrop) and the efficiency with which Ftrop heats the surface in the RCP8.5 warming scenario of the Community Earth System Model Large Ensemble. A metric for this efficiency, Etrop, measures the fraction of anomalous Ftrop that is balanced by an anomalous net surface flux (NSF). Drivers of Etrop are identified in synoptic‐scale events during which Ftrop is the dominant driver of NSF. Etrop is sensitive to the vertical structure of Ftrop and pre‐existing Arctic lower‐tropospheric stability (LTS). In RCP8.5, winter‐mean Ftrop decreases from 95.1 to 85.4 W m−2, while Etrop increases by 5.7%, likely driven by decreased Arctic LTS, indicating an increased coupling between Ftrop and the surface energy budget. The net impact of decreasing Ftrop and increasing efficiency is a positive 0.7 W m−2 contribution to winter‐season surface heating.
Gigantic Vortices From Barotropic Instability Observed in the Atmosphere of Venus
Authors: Horinouchi Takeshi , Satoh Takehiko , Peralta Javier
Published: January 2023

Until recently, the lower to middle cloud region of Venus had been supposed to be dynamically quiet, accommodating nearly steady superrotating westward flow. However, observations of the regions by Akatsuki, the latest Venus orbiter operating since 2015, have revealed a variety of cloud features indicative of vortices and waves. Here we report another, and arguably the most conspicuous, example. Akatsuki's near‐infrared imager IR2 captured gigantic vortices rotating cyclonically on 25 August 2016. By using winds estimated by cloud tracking, the feature is shown to be quantitatively consistent with barotropic instability. The size of the vortices (∼1,000 km) and their spacing (∼2,500 km) are more than several times greater than the vortex‐like features reported previously from the observations of Venus, and they are also greater than the largest barotropic instability observed in the Earth's troposphere.
Internal Structure of the Central Garlock Fault Zone From Ridgecrest Aftershocks Recorded by Dense Linear Seismic Arrays
Authors: Qiu Hongrui , Chi Benxin , Ben‐Zion Yehuda
Published: January 2023

We provide high‐resolution seismic imaging of the central Garlock fault using data recorded by two dense seismic arrays that cross the Ridgecrest rupture zone (B4) and the Garlock fault (A5). Analyses of fault zone head waves and P‐wave delay times at array A5 show that the Garlock fault is a sharp bimaterial interface with P waves traveling ∼5% faster in the northern crustal block. The across‐fault velocity contrast agrees with regional tomography models and generates clear P‐wave reflections in waveforms recorded by array B4. Kirchhoff migration of the reflected waves indicates a near‐vertical fault between 2 and 6 km depth. The P‐wave delay times imply a ∼300‐m‐wide transition zone near the Garlock fault surface trace beneath array A5, offset to the side with faster velocities. The results provide important constraints for derivations of earthquake properties, simulations of ruptures and ground motion, and future imaging studies associated with the Garlock fault.
The Impact of Climate Change on River Alternate Bars
Authors: Redolfi M. , Carlin M. , Tubino M.
Published: January 2023

Climate change is expected to alter the distribution of flow discharge in rivers worldwide. We study the impact of climate‐driven flow changes on the shape of riverbed, and specifically on alternate bars, large deposits of gravel/sand that often form in rivers. We consider the illustrative example of the Alpine Rhine River, showing two nearby reaches with similar hydro‐morphological characteristics, but different channel width. Hydrological projections are obtained from literature, while the evolution of alternate bars is predicted through a novel, semi‐analytical model. Results show a remarkably different behavior of the two reaches: the upstream one, being wide enough for a full development of alternate bars, is resistant to flow alterations; the downstream reach, whose width is close to threshold conditions, is highly susceptible to future changes, showing a strong tendency to increase bar prominence. These findings reflect a general tendency of near‐threshold geomorphic systems to be vulnerable to anthropic stressors.
New Early Neoproterozoic Paleomagnetic Constraints of the Northwestern China Blocks on the Periphery of Rodinia
Authors: Xu Yan , Zhang Shihong , Zhang Chuanlin , Ye Xiantao , Ren Qiang , Gao Yangjun , Li Haiyan , Yang Tianshui , Wu Huaichun
Published: January 2023

Recent studies highlight the debates about the role of the northwestern China blocks, for example, north Tarim block, south Tarim block (STB), Altyn Tagh block (ATB) and Qaidam‐Qilian block (QQB) during the assembly of Rodinia. We herein present a combined paleomagnetic, geochronological, and geochemical study on 16 mafic dikes in the northern ATB. After removing a recent viscous remanent magnetization, three characteristic remanent magnetization components (CHs) were isolated. CH1 was identified in eight NW‐trending diabase dikes, one of which was newly dated at 895.3 ± 7.7 Ma through use of SHRIMP baddeleyite U‐Pb methodology. It yields a mean direction (D/I) of 123.3°/−42.2° (α95 = 12.1°). The paleopole (40.9°S/184.6°E, A95 = 11.7°) was calculated by averaging eight virtual geomagnetic poles (VGPs) from each dike. A partial baked‐contact test supports the primary origin of CH1. CH2 was isolated from three E‐W trending diabase dikes, pointing northwest with considerably shallower downward inclinations. CH3 was obtained from five lamprophyre dikes, directing southeast with moderate to shallow upward inclinations. However, the VGPs of either CH2 or CH3 are insufficient to average a precise mean pole. Geochemical analyses also reveal petrogenetic discrepancy among the dikes with distinct CHs. Combining the new ∼895 Ma pole of CH1 with the global paleomagnetic database and being aided by geological evidence, we propose that the STB‐ATB‐QQB and the north China craton were located along the northwestern side of Laurentia in Rodinia at ∼895 Ma, and suggest the connection might have been intact until ∼780 Ma.
Effect of Estuary Urbanization on Tidal Dynamics and High Tide Flooding in a Coastal Lagoon
Authors: Pareja‐Roman L. Fernando , Orton P. M. , Talke S. A.
Published: January 2023

High tide floods (HTFs) are minor, shallow flooding events whose frequency has increased due to relative sea‐level rise (SLR) and secular changes in tides. Here we isolate and examine the role of historical landscape change (geomorphology, land cover) and SLR on tides and HTF frequency in an urbanized lagoonal estuary: Jamaica Bay, New York. The approach involves data archeology, historical (1870s) map digitization, as well as numerical modeling of the bay. Numerical simulations indicate that a century of landscape alterations (e.g., inlet deepening and widening, channel deepening, and wetland reclamation) increased the mean tidal range at the head of the bay by about 20%. The observed historical shift from the attenuation to amplification of semidiurnal tides is primarily associated with reduced tidal damping at the inlet and increased tidal reflection. The 18% decrease in surface area exerts a minor influence. A 1‐year (2020) water level simulation is used to evaluate the effects of both SLR and altered morphology on the annual number of HTFs. Results show that of 15 “minor flood” events in 2020, only one would have occurred without SLR and two without landscape changes since the 1870s. Spectral and transfer function analyses of water level reveal frequency‐dependent fingerprints of landscape change, with a significant decrease in damping for high‐frequency surges and tides (6–18 hr time scale). By contrast, SLR produced only minor effects on frequency‐dependent amplification. Nonetheless, the geomorphic influence on the dynamical response significantly increases the vulnerability of the system to SLR, particularly high‐tide flooding.
Multi‐Scale Temporal Variability of Turbulent Mixing During a Monsoon Intra‐Seasonal Oscillation in the Bay of Bengal: An LES Study
Authors: Pham Hieu T. , Sarkar Sutanu , Johnson Leah , Fox‐Kemper Baylor , Sullivan Peter P. , Li Qing
Published: January 2023

A process study using large‐eddy simulations is carried out to explore the dominant 1‐D processes that affect mixed layer (ML) properties during an event of summer Monsoon Intra‐seasonal Oscillations (MISO) in the Bay of Bengal (BOB). These simulations use realistic air‐sea fluxes and initial conditions that were collected during the summer 2018 MISO‐BOB field experiment to explore the roles of thermal inversion layer (TIL) and Langmuir turbulence (LT) in modulating ML properties. The simulations span an active period with heavy rain and strong winds and a break period with strong solar heat flux and little rain. The mixed layer depth (MLD), sea surface temperature (SST) and sea surface salinity (SSS) are most affected by the presence of near‐inertial oscillations, solar heating and precipitation, all of which occur at different timescales. The subsurface warming induced by the TIL reduces the SST variability at the MISO timescale when compared with the simulation without TIL. Comparison of simulations with and without LT indicates that LT enhances subsurface warming during the active phase and reduces diurnal SST modulation during the break phase. Simulations with 1‐D mixing models show a wide disparity in the evolution of MLD, SST, and SSS.
Tumor-intrinsic IRE1α signaling controls protective immunity in lung cancer
Authors: Crowley Michael J. P. , Bhinder Bhavneet , Markowitz Geoffrey J. , Martin Mitchell , Verma Akanksha , Sandoval Tito A. , Chae Chang-Suk , Yomtoubian Shira , Hu Yang , Chopra Sahil , Tavarez Diamile A. , Giovanelli Paolo , Gao Dingcheng , McGraw Timothy E. , Altorki Nasser K. , Elemento Olivier , Cubillos-Ruiz Juan R. , Mittal Vivek
Published: January 2023

IRE1α-XBP1 signaling is emerging as a central orchestrator of malignant progression and immunosuppression in various cancer types. Employing a computational XBP1s detection method applied to TCGA datasets, we demonstrate that expression of the XBP1s mRNA isoform predicts poor survival in non-small cell lung cancer (NSCLC) patients. Ablation of IRE1α in malignant cells delays tumor progression and extends survival in mouse models of NSCLC. This protective effect is accompanied by alterations in intratumoral immune cell subsets eliciting durable adaptive anti-cancer immunity. Mechanistically, cancer cell-intrinsic IRE1α activation sustains mPGES-1 expression, enabling production of the immunosuppressive lipid mediator prostaglandin E2. Accordingly, restoring mPGES-1 expression in IRE1αKO cancer cells rescues normal tumor progression. We have developed an IRE1α gene signature that predicts immune cell infiltration and overall survival in human NSCLC. Our study unveils an immunoregulatory role for cancer cell-intrinsic IRE1α activation and suggests that targeting this pathway may help enhance anti-tumor immunity in NSCLC.
Apremilast prevents blistering in human epidermis and stabilizes keratinocyte adhesion in pemphigus
Authors: Sigmund Anna M. , Winkler Markus , Engelmayer Sophia , Kugelmann Daniela , Egu Desalegn T. , Steinert Letyfee S. , Fuchs Michael , Hiermaier Matthias , Radeva Mariya Y. , Bayerbach Franziska C. , Butz Elisabeth , Kotschi Stefan , Hudemann Christoph , Hertl Michael , Yeruva Sunil , Schmidt Enno , Yazdi Amir S. , Ghoreschi Kamran , Vielmuth Franziska , Waschke Jens
Published: January 2023

Pemphigus vulgaris is a life-threatening blistering skin disease caused by autoantibodies destabilizing desmosomal adhesion. Current therapies focus on suppression of autoantibody formation and thus treatments directly stabilizing keratinocyte adhesion would fulfill an unmet medical need. We here demonstrate that apremilast, a phosphodiesterase 4 inhibitor used in psoriasis, prevents skin blistering in pemphigus vulgaris. Apremilast abrogates pemphigus autoantibody-induced loss of keratinocyte cohesion in ex-vivo human epidermis, cultured keratinocytes in vitro and in vivo in mice. In parallel, apremilast inhibits keratin retraction as well as desmosome splitting, induces phosphorylation of plakoglobin at serine 665 and desmoplakin assembly into desmosomal plaques. We established a plakoglobin phospho-deficient mouse model that reveals fragile epidermis with altered organization of keratin filaments and desmosomal cadherins. In keratinocytes derived from these mice, intercellular adhesion is impaired and not rescued by apremilast. These data identify an unreported mechanism of desmosome regulation and propose that apremilast stabilizes keratinocyte adhesion and is protective in pemphigus.
Widely conserved AHL transcription factors are essential for NCR gene expression and nodule development in Medicago
Authors: Zhang Senlei , Wang Ting , Lima Rui M. , Pettkó-Szandtner Aladár , Kereszt Attila , Downie J. Allan , Kondorosi Eva
Published: January 2023

Symbiotic nitrogen fixation by Rhizobium bacteria in the cells of legume root nodules alleviates the need for nitrogen fertilizers. Nitrogen fixation requires the endosymbionts to differentiate into bacteroids which can be reversible or terminal. The latter is controlled by the plant, it is more beneficial and has evolved in multiple clades of the Leguminosae family. The plant effectors of terminal differentiation in inverted repeat-lacking clade legumes (IRLC) are nodule-specific cysteine-rich (NCR) peptides, which are absent in legumes such as soybean where there is no terminal differentiation of rhizobia. It was assumed that NCRs co-evolved with specific transcription factors, but our work demonstrates that expression of NCR genes does not require NCR-specific transcription factors. Introduction of the Medicago truncatula NCR169 gene under its own promoter into soybean roots resulted in its nodule-specific expression, leading to bacteroid changes associated with terminal differentiation. We identified two AT-Hook Motif Nuclear Localized (AHL) transcription factors from both M. truncatula and soybean nodules that bound to AT-rich sequences in the NCR169 promoter inducing its expression. Whereas mutation of NCR169 arrested bacteroid development at a late stage, the absence of MtAHL1 or MtAHL2 completely blocked bacteroid differentiation indicating that they also regulate other NCR genes required for the development of nitrogen-fixing nodules. Regulation of NCRs by orthologous transcription factors in non-IRLC legumes opens up the possibility of increasing the efficiency of nitrogen fixation in legumes lacking NCRs.
Theoretical error performance analysis for variational quantum circuit based functional regression
Authors: Qi Jun , Yang Chao-Han Huck , Chen Pin-Yu , Hsieh Min-Hsiu
Published: January 2023

The noisy intermediate-scale quantum devices enable the implementation of the variational quantum circuit (VQC) for quantum neural networks (QNN). Although the VQC-based QNN has succeeded in many machine learning tasks, the representation and generalization powers of VQC still require further investigation, particularly when the dimensionality of classical inputs is concerned. In this work, we first put forth an end-to-end QNN, TTN-VQC, which consists of a quantum tensor network based on a tensor-train network (TTN) for dimensionality reduction and a VQC for functional regression. Then, we aim at the error performance analysis for the TTN-VQC in terms of representation and generalization powers. We also characterize the optimization properties of TTN-VQC by leveraging the Polyak-Lojasiewicz condition. Moreover, we conduct the experiments of functional regression on a handwritten digit classification dataset to justify our theoretical analysis.
Non-linear Boson Sampling
Authors: Spagnolo Nicolò , Brod Daniel J. , Galvão Ernesto F. , Sciarrino Fabio
Published: January 2023

Boson Sampling is a task that is conjectured to be computationally hard for a classical computer, but which can be efficiently solved by linear-optical interferometers with Fock state inputs. Significant advances have been reported in the last few years, with demonstrations of small- and medium-scale devices, as well as implementations of variants such as Gaussian Boson Sampling. Besides the relevance of this class of computational models in the quest for unambiguous experimental demonstrations of quantum advantage, recent results have also proposed the first applications for hybrid quantum computing. Here, we introduce the adoption of non-linear photon–photon interactions in the Boson Sampling framework, and analyze the enhancement in complexity via an explicit linear-optical simulation scheme. By extending the computational expressivity of Boson Sampling, the introduction of non-linearities promises to disclose novel functionalities for this class of quantum devices. Hence, our results are expected to lead to new applications of near-term, restricted photonic quantum computers.
Cooperative adaptive management of the Nile River with climate and socio-economic uncertainties
Authors: Basheer Mohammed , Nechifor Victor , Calzadilla Alvaro , Gebrechorkos Solomon , Pritchard David , Forsythe Nathan , Gonzalez Jose M. , Sheffield Justin , Fowler Hayley J. , Harou Julien J.
Published: January 2023

The uncertainties around the hydrological and socio-economic implications of climate change pose a challenge for Nile River system management, especially with rapidly rising demands for river-system-related services and political tensions between the riparian countries. Cooperative adaptive management of the Nile can help alleviate some of these stressors and tensions. Here we present a planning framework for adaptive management of the Nile infrastructure system, combining climate projections; hydrological, river system and economy-wide simulators; and artificial intelligence multi-objective design and machine learning algorithms. We demonstrate the utility of the framework by designing a cooperative adaptive management policy for the Grand Ethiopian Renaissance Dam that balances the transboundary economic and biophysical interests of Ethiopia, Sudan and Egypt. This shows that if the three countries compromise cooperatively and adaptively in managing the dam, the national-level economic and resilience benefits are substantial, especially under climate projections with the most extreme streamflow changes.
Continuous exposure to isoprenaline reduced myotube size by delaying myoblast differentiation and fusion through the NFAT-MEF2C signaling pathway
Authors: Yue Jing , Xu Wei , Xiang Li , Chen Shao-juan , Li Xin-yuan , Yang Qian , Zhang Ruo-nan , Bao Xin , Wang Yan , Mbadhi MagdaleenaNaemi , Liu Yun , Yao Lu-yuan , Chen Long , Zhao Xiao-ying , Hu Chang-qing , Zhang Jing-xuan , Zheng Hong-tao , Wu Yan , Chen Shi-You , Li Shan , Lv Jing , Shi Liu-liu , Tang Jun-ming
Published: January 2023

We aimed to explore whether superfluous sympathetic activity affects myoblast differentiation, fusion, and myofiber types using a continuous single-dose isoprenaline exposure model in vitro and to further confirm the role of distinct NFATs in ISO-mediated effects. Compared with delivery of single and interval single, continuous single-dose ISO most obviously diminished myotube size while postponing myoblast differentiation/fusion in a time- and dose-dependent pattern, accompanied by an apparent decrease in nuclear NFATc1/c2 levels and a slight increase in nuclear NFATc3/c4 levels. Overexpression of NFATc1 or NFATc2, particularly NFATc1, markedly abolished the inhibitory effects of ISO on myoblast differentiation/fusion, myotube size and Myh7 expression, which was attributed to a remarkable increase in the nuclear NFATc1/c2 levels and a reduction in the nuclear NFATc4 levels and the associated increase in the numbers of MyoG and MEF2C positive nuclei within more than 3 nuclei myotubes, especially in MEF2C. Moreover, knockdown of NFATc3 by shRNA did not alter the inhibitory effect of ISO on myoblast differentiation/fusion or myotube size but partially recovered the expression of Myh7, which was related to the slightly increased nuclear levels of NFATc1/c2, MyoG and MEF2C. Knockdown of NFATc4 by shRNA prominently increased the number of MyHC +, MyoG or MEF2C + myoblast cells with 1 ~ 2 nuclei, causing fewer numbers and smaller myotube sizes. However, NFATc4 knockdown further deteriorated the effects of ISO on myoblast fusion and myotube size, with more than 5 nuclei and Myh1/2/4 expression, which was associated with a decrease in nuclear NFATc2/c3 levels. Therefore, ISO inhibited myoblast differentiation/fusion and myotube size through the NFAT-MyoG-MEF2C signaling pathway.