bluuebunny/crossref_metadata_2025 huggingface dataset:
Simulation based Single cell and Multi Cell Monitoring Management with SOC & SOH Control for Continuous working of Electric Vehicle/ Grid Connected System
Authors: V Kandaswamy K , B Raj Narain
Published: February 2023

Electric vehicles (EVs) and smart grids are two examples of high-power applications that frequently use lithium-ion pack and a battery management system (BMS). Battery status estimation, defect detection, monitoring, and control functions are required for BMS implementations, which require both software and hardware. Predicting battery life aids in the consistent and efficient operation of battery-powered equipment. The proposed method uses Portable and continuous monitoring of the battery life to prevent from sudden discharge, High temperature with frequent charging and discharging system. Voltage, current, and temperature sensors are used to detect the voltage, current, and temperature of the cells. The controller receives the data from each sensor connected at different node gives the update continuously to the monitor. Similarly, the controller prevents the battery from over discharge and under discharge of each cell. Apart from regular monitoring and controlling of each cell, a novel method is proposed in the existing circuit for partial or full charging during idling condition. Monitoring the battery state continuously allows for balanced charging of the battery cells and overcharge prevention. The suggested concept includes a Graphical User Interface (GUI), a method for training a model, and test results for the BMS.
Market Basket Analysis with Statistically Improved Association Rules Considering Product Details
Authors: Dogan Onur
Published: February 2023

E-commerce companies need to direct customers to choose the wished products. A significant challenge in the e-commerce domain forces to use of technology and data-oriented solutions. So, investigating the sales transactions is necessary thanks to the high number of product varieties for product recommendation. Although creating association rules with many algorithms is common, this study improves the traditional association rule mining (ARM) method by adding a different perspective, named statistical settings, to create more insights for managerial implications. After generating rules, it checks the statistical significance of the correlation, considering some product-specific details, such as product name, discount rates, and the number of favorites. The study concluded with exciting insights. For example, the company should recommend products with a lower discount rate if the customer puts products in the basket with a high discount rate. It also enriches traditional rules by adding product features. When the total number of favorites is less than 7500, and the discount rate is less than 75\%, the similarity ratio of the Conclusion products should be less than 0.50.
Pressure recovery model for gas-liquid two-phase flow across sudden expansions
Authors: Arabi Abderraouf , Abdul-Majeed Ghassan H. , Boukrouche Houari B. , Larbi Zakaria
Published: February 2023

The presence of a sudden expansion generates a variation of the static pressure commonly called Pressure Recovery (PR). In this paper, we made firstly an extensive literature survey to list existing gas-liquid two-phase flow pressure recovery models and to collect an experimental database. Thus, a total of 305 data was collected from 6 recent works and 18 predictive models was identified. An analysis of the different existing models was carried out firstly. Then, the predictive capability of nine existing models was assessed using the collected database. It was reported that none of the models can predict the experimental results for a large range of experimental conditions. This finding highlighted the necessity to propose a new model. The proposed predictive model was developed using the two-phase multiplier and mass quality. These two parameters were correlated using 157 data points from the collected database, while the other data was used to validate it. It was found that the proposed model gives better predictions compared to existing ones in the range of conditions and parameters of the experimental database used in this analysis.
Blocking the FAM19A5-LRRC4B complex enhances neurite growth and synapse assembly.
Authors: Seong Jae Young
Published: February 2023

Disruption in dynamic balance of synapse build-and-removal process is a major cause of neurological diseases, although the mechanisms underlying the brain fine-tunes and balances this process remain poorly understood. Here, we show that FAM19A5 binds to the postsynaptic adhesion molecule LRRC4B via the FAM19A5 binding (FB) domain, suppressing the interaction of LRRC4B with a presynaptic adhesion molecule PTPRF. Decoys with the FB domain bind to FAM19A5 and redirect it away from the FAM19A5-LRRC4B complex, promoting neurite growth and synapse formation of neurons. The anti-FAM19A5 monoclonal antibody NS101 breaks apart the FAM19A5-LRRC4B complex and enables the transfer of FAM19A5 from the brain into the bloodstream, leading to the restoration of synaptic integrity and improve cognitive function in mouse models of Alzheimer’s disease. Together, our findings suggest that blocking the complex with NS101 may offer therapeutic strategy for treating neurodegenerative diseases requiring regeneration of neurites and formation of new synapses.
BREAST CANCER WITH MICROCALCIFICATES: A BIBLIOMETRIC ANALYSIS
Authors: Kolomiiets Olena , Moskalenko Roman
Published: February 2023

Introduction. Microcalcifications in breast tissue are an important marker of the tumor process and are crucial for early diagnosis of this pathology. Detection of microcalcifications in the breast gland using mammography is of great importance in the diagnosis of breast cancer (BC), especially in the early stages. The presence of microcalcifications in the mammary gland indicates a worse prognosis, mainly due to a higher frequency of lymph node invasion and rapid metastasis.
The objective of the paper is the bibliometric analysis and research of data on the pathomorphological characteristics of breast cancer with biomineralization.
Materials and methods. The authors searched for information on BC in electronic databases such as PubMed, Scopus, Web of Science, and Google Scholar using key terms such as "breast cancer," "calcification," "microcalcifications". For bibliometric analysis, we used SciVal (Scopus) online platform for monitoring and analyzing international scientific research using visualization tools and modern citation metrics and VOSviewer tool for building and visualizing bibliometric networks.
Results. The presence of microcalcifications in the mammary gland correlates with a worse prognosis, especially due to a higher frequency of lymph node invasion and rapid metastasis.
It is important to distinguish microcalcifications by type and origin, as they can be an indicator of differential diagnosis of the pathological process in the tissue of the gastrointestinal tract, namely, benign and malignant pathology.
We performed a bibliometric analysis of the scientific sources of the Scopus database, which included 924 publications. The main keywords for the bibliometric analysis were "breast cancer", "calcification", "microcalcifications". The results of the analysis indicated that the number of publications on the specified subject had increased over the past 10 years, which showed the relevance of the problem among scientists.
Among the most interesting areas, we singled out the papers devoted to the classification of breast cancers, early diagnosis of breast cancer, and classification of biomineral deposits.
In order to build and visualize bibliometric networks, we used the VOSviewer publication activity tool.
Conclusions. For the period of 1967–2022, we identified 4 chronological stages from the bibliometric analysis results in the Scopus database, which included: 1) radiological methods of research – mammography, 2) pathomorphological assessment of cervical cancer and calcifications, 3) study of BC progression biomarkers, 4) prognostic assessment of BC depending on metastasis and survival. We divided all publications into 6 thematic clusters: 1) classification of biominerals, 2) mammography, 3) physico-chemical composition of calcifications, 3) ductal neoplasia of the breast, 4) biopsy, 5) metastasis of cervical cancer, 6) calcium hydroxyapatite.
THE ROLE OF А PHYSICAL THERAPIST IN THE CATAMNESIS SYSTEM
Authors: Holiuk Kateryna , Kuksa Nataliya , Taramak Liudmyla , Klishch Olha
Published: February 2023

Numerous scientific and clinical studies demonstrate an increase in the number of children born prematurely and with perinatal pathology. After discharge from perinatal centers, they form risk groups for chronic, disabling diseases development. Such children are usually more socially isolated, characterized by attention deficit and greater hyperactivity compared to full-term children.
Physical therapists play an important role in monitoring motor development and detecting delays, as well as informing parents about possible difficulties that may be observed in such children.
Materials and methods. The study included 36 children who were being treated at the Ukrainian North-Eastern Institute of Applied and Clinical Medicine in Sumy. By gender, there were 22 (61.1%) male children and 14 (38.9%) female children. The birth weight ranged from 1090 to 2440 g. All children had a history of perinatal hypoxic-ischemic lesions of the central nervous system, periventricular ischemia of various degrees. A third of the children were diagnosed with subependymal hemorrhage and cerebrospinal fluid hypertension of various degrees.
Based on the results of studying the anamnesis, interviewing parents, and detailed information, the main and control groups were formed and the strategy for the habilitation program implementation was determined. Both groups included 18 children aged 13 to 23 months. The children of the control group underwent the habilitation course according to the standard program, while the children of the main group were treated according to the developed experimental physical therapy program.
Results. The results of the experimental study showed positive changes in children's weight; muscle tone of the lower and upper limbs; motor, sensory, adaptive, and social behavior of children.
Conclusions. A complex of medical, rehabilitation, pedagogical, logopedic therapy, and other measures should be started already in the first year of life. It is important to ensure the sequence of stages of recovery measures. Rehabilitation started at the wrong time may prove to be ineffective. All interventions should be selected individually for each child, carried out with the support and supervision of an occupational therapist, and in close cooperation with parents and physiotherapists/occupational therapists.
A KNOWLEDGE, ATTITUDE AND PRACTICE STUDY OF PRESCRIBING OXYGEN AMONGST INTERNS IN A TERTIARY CARE HOSPITAL
Authors: Siwach Ishaan , Yadav Siddharth Raj , Kumar Rohit , Choudhari Omkar Kalidasrao , Kumar Amit , Ish Pranav , Gupta Nitesh
Published: February 2023

Background: Oxygen is one of the most frequently prescribed health-care interventions and resuscitative methods to patients visiting the emergency or while admitted to the hospital. The ongoing COVID pandemic has emphasized the importance of efficient and optimal oxygen utilization. The interns in a teaching hospital are often the first point of contact for patients.
Materials and Methods: A cross-sectional questionnaire-based study was done amongst 100 interns posted in areas where oxygen is routinely prescribed. For this study, a questionnaire was devised by the investigators to assess the Knowledge, Attitude and Practice of prescribing oxygen therapy. The questionnaire also included the validated acute oxygen therapy questionnaire (AOTQ).
Results: Knowledge of participants ascertained using the validated AOTQ questionnaire revealed a score of 16.59 ± 1.94 out of a maximum of 23 points suggesting that majority of participants possessed mediocre knowledge. The author’s questionnaire showed significant gaps in knowledge and attitude; participants were relatively ill-informed about the interfaces used, the indications, and monitoring required while administering oxygen.
Conclusion: There is an admissible gap in knowledge, attitude and practices pertaining to oxygen therapy as compared to the ideal. The development of standard training guidelines and suitable methodologies is absolutely crucial so that optimal therapy can be provided by fresh medical graduates without compromising patient care.
INFLAMMATION INDEXES AS PREDICTORS OF RECURRENCE IN PATIENTS WITH SURGICALLY RESECTED NON-SMALL CELL LUNG CANCER
Authors: Smorodska Оlga , Moskalenko Yuliia , Kononenko Мykola , Ivanov Stanislav
Published: February 2023

Introduction. Prediction of lung cancer recurrence is one of the most urgent problems of modern oncology. Scientists are trying to find independent predictors that will help intensify, personalize the patient's treatment, and prevent the disease relapse on time.
The study aimed to find indicators of inflammation that could be independent predictors of disease recurrence in patients with surgically resected non-small cell lung cancer.
Materials and methods. The study was conducted retrospectively. The study group included 104 patients with non-small cell lung cancer who received surgical treatment and adjuvant chemotherapy or chemoradiotherapy from 2014 to 2018 at the Sumy Regional Clinical Oncology Dispensary. Based on the results of the blood count tests, the inflammation indices were calculated before chemotherapy or chemoradiotherapy and one month after their completion. Systemic inflammatory response index (SIRI), systemic inflammatory index (SII), neutrophil/lymphocyte ratio (NLR), platelets/lymphocytes ratio (PLR), lymphocyte/monocyte ratio (LMR), monocyte/lymphocyte ratio (MLR) were calculated. Using ROC analysis, cut-off points were found. Cox regression was used to find independent predictors of lung cancer recurrence.
Results. During the observation period, relapse of the disease was recorded in 42 (40.4%) patients. The average recurrence-free survival was 56.3 months, range of 4–84.0 months (95% CI = 46.866–65.683). Before chemo- or chemoradiation therapy, the cut-off points for NLR1, PLR1, MLR1, LMR1, SII1, and SIRI1 were 1.80, 126.35, 0.22, 4.80, 521.22 and 0.96, respectively. Cut-off points for NLR2, PLR2, MLR2, LMR2, SII2, and SIRI2 at stage one month after completing courses of chemotherapy or chemoradiotherapy were 1.33, 153.80, 0.26, 3.98, 450.10 and 0.82 respectively. According to ROC analysis, only PLR1, SII1, LMR1, and LMR2 indices are reliable and can be used in further Cox regression analysis. Univariant Cox regression showed that LMR1 and SII1 were significantly associated with disease recurrence. Multivariate Cox regression identified SII1 as the only independent predictor of disease recurrence.
Conclusions. Among numerous inflammation indices as an independent predictor for disease recurrence in non-small cell lung cancer patients who received surgical treatment and chemotherapy or chemoradiotherapy, only systemic inflammation index (SII1) at the stage before chemotherapy or chemoradiotherapy can be used. Indicators above 521.22 could be a predictor of high-risk recurrence of lung cancer.
IMPRESSÃO 3D DE SEPARADOR MAGNÉTICO: UMA ABORDAGEM ACESSÍVEL PARA O PREPARO DE AMOSTRAS NO DIAGNÓSTICO DA COVID-19
Authors: Silva-Neto Habdias , Duarte-Junior Gerson , Bazílio Gabriela , Parente-Rocha Juliana , Colugnati Diego , Borges Clayton , Coltro Wendell
Published: February 2023

3D PRINTING OF MAGNETIC SEPARATOR: AN AFFORDABLE APPROACH TO SAMPLE PREPARATION IN THE COVID-19 DIAGNOSIS. This report describes the fabrication of a low-cost magnetic separator holder combining 3D printing and compact neodymium blocks for allowing magnetic extraction and purification of RNA from samples collected by nasopharyngeal swab from patients infected by SARS-CoV-2. The device was designed to contain 24 entrances for plastic microtubes in an arrangement like a commercial device. The proof of concept of the proposed device was successfully demonstrated through the sample extraction and purification of swab samples collected from eight patients suspected of SARS-CoV-2 infection. The sample preparation protocol was performed using a commercial kit containing magnetic beads and different solutions. The performance of the printed device was compared to a commercial magnetic separator, usually employed in the golden standard techniques. The fabrication of the 3D printed magnetic separator was completed under optimized printing conditions within 6 h at cost of 4 USD per unit. The RNA extracted from samples using both devices was analyzed by reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) and the achieved results have indicated no statistical different at confidence level of 95%. Based on the achievements, the use of 3D printing and neodymium blocks have demonstrated an alternative route to be used in routing analysis associated to COVID-19 diagnosis.
Akdeniz – Güneydoğu Anadolu Geçit Kuşağı Koşullarına Uygun Hargreaves Modeli Solar Radyasyon Tahmin Eşitliğinin Geliştirilmesi ve Test Edilmesi
Authors: USTA Selçuk , GENÇOĞLAN Serpil , GENÇOĞLAN Cafer
Published: February 2023

Bu çalışmada, Hargreaves solar radyasyon (Rs) tahmin modelinin Akdeniz – Güneydoğu Anadolu geçit kuşağı koşullarına uygun kalibrasyonunun yapılması ve test edilmesi amaçlanmıştır. Kalibrasyon eşitliğinin oluşturulmasında Kahramanmaraş iline ait maksimum, minimum, ortalama hava sıcaklığı (Tmax, Tmin, T), Rs ve extraterrestrial radyasyon (Ra) verilerinin uzun yıllar ortalaması (1938 – 2020) günlük değerleri kullanılmıştır. Ra değerleri coğrafi konum ve zamana bağlı olarak tahmin edilmiştir. Kalibrasyon katsayıları (a, b) Microsoft Excel programı çözücü eklentisi kullanılarak, sırasıyla 0.0984 ve 0.3695 olarak belirlenmiştir. Uzun yıllar ortalaması günlük Rs değerleri 4.99 – 32.56 MJ/m2 gün, kalibrasyon eşitliği kullanılarak tahmin edilen Rs değerleri ise 7.33 – 33.25 MJ/m2 gün aralığında değişmiştir. Ölçülen değerlerdeki değişimin tahmin değerleri ile açıklanabilme oranı %97.34 (R2= 0.9734) olarak elde edilmiştir. Ölçülen ve tahmin edilen Rs değerleri arasındaki sapmanın bir göstergesi olarak dikkate alınan ortalama mutlak göreceli hata oranı (MAPE) ve karekök ortalama karesel hata (RMSE) sırasıyla %8.71 ve 1.54 MJ/m2 olarak belirlenmiştir. Kalibrasyon eşitliği Kahramanmaraş Sütçü İmam Üniversitesinde (KSÜ) 2021 yılında ölçülen günlük ortalama Tmax, Tmin, T ve Rs verileri ile test edilmiştir. Bu verilerin ölçülmesinde Programlanabilir Lojik Kontrolör (PLC) tarafından yönetilen sıcaklık ve radyasyon sensörleri kullanılmıştır. Ölçülen ve tahmin edilen günlük Rs değerleri sırasıyla 10.40 – 29.13 MJ/m2 gün ve 13.80 – 31.16 MJ/m2 aralıklarında değişmiştir. Ölçülen değerlerdeki değişimin tahmin değerleri ile açıklanabilme oranı %86.71 (R2= 0.8671) olarak belirlenmiştir. MAPE ve RMSE sırasıyla %10.57 ve 2.57 MJ/m2 olarak elde edilmiştir. Yöre koşulları ile uyumlu Hargreaves modeli kalibrasyon eşitliği kullanılarak, doğruluk oranı yüksek solar radyasyon tahminleri yapılabileceği sonucuna ulaşılmıştır.
Pathogenetic mechanisms of damage to the cardiovascular system in new coronavirus infection (COVID-19)
Authors: Stepchenko Alexander A. , Gnezdilova Evgeniya S. , Stepchenko Marina A. , Trigub Anastasia V.
Published: February 2023

Objective of the study: to analyze and systematize the results of fundamental and clinical studies of recent years devoted to the study of the pathogenetic mechanisms of myocardial and coronary artery damage in patients who have undergone a new coronavirus infection (COVID-19). Materials and methods. The search for scientific information was carried out in domestic (E-Library) and foreign databases (PubMed, Scopus, Oxford University Press, Springer, Web of Science Core Collection). Results. It has been shown that the variety of cardiovascular system pathologies after a coronavirus infection is quite wide: heart failure, arrhythmias, sudden cardiac death, coronary heart disease, coronary microvascular dysfunction with coronary insufficiency, formation of coronary artery and aortic aneurysms, hypertension, labile heart rate and BP response to physical activity, acceleration of atherogenesis processes, venous and arterial thromboembolism. Cardiovascular pathology can develop both in patients after severe and moderate COVID-19, and in oligosymptomatic and asymptomatic individuals. Patients with emerging cardiovascular pathology in the acute period of coronavirus infection, as a rule, are under observation and in this situation changes in therapeutic strategies occur faster. Patients with newly diagnosed cardiovascular pathology after suffering COVID-19 need special attention and timely assessment to exclude or confirm cardiovascular complications. Conclusion. The presented data suggest that the tactics and strategy for the management of cardiovascular diseases in the post-covid period should be based on the timely and modern diagnosis of the onset or decompensation of cardiovascular pathology, competent, in accordance with current recommendations management of cardiovascular pathology with emphasis on the use of therapeutic interventions affecting the pathophysiological mechanisms of long covid.
Choice of treatment for «hard-to-treat» cases of plantar fasciitis
Authors: Lazarenko Victor A. , Mishustin Vladimir N. , Bobrovskaya Elena A.
Published: February 2023

Objective: to develop an algorithm for choosing a treatment method for "difficult" cases of plantar fasciitis. Materials and methods. The clinical research included 40 patients with plantar fasciitis. These patients had so-called «hard-to-treat» cases of plantar fasciitis. These are: patients previously treated with local hormone injections or FSWT. There was no effect from the treatment. Depends on the clinical picture, the patients were divided into 3 groups: the main group (n=20) - patients with «hard-to-treat» cases, who underwent combined focused(FSWT) and radial shock wave therapy(RSWT); compare group (n=10) - patients who received only FSWT; control group(n=10) - patients who underwent local injection of hormones. Results. It was found that that the complex treatment of plantar fasciitis with radial and focused shock wave therapy in patients in «difficult cases» allows obtaining satisfactory results in 97% of patients 4 weeks after the end of treatment. This is significantly higher than with treatment with only focused shock wave and local hormone therapy (p<0.05). Moreover, hormone therapy was effective only in 4 (40%) patients who had previously received shock wave therapy. In patients with previous local injection of hormones, it was ineffective. Only focused shock wave therapy relieved pain syndrome in 6 (60%) patients. Conclusion. The study of the results of the treatment of «difficult» cases of plantar fasciitis by the method of radial and focused shock waves in combination, as well as only by the method of focused shock wave therapy and local injection with hormones will allow us to form an algorithm for the treatment of such patients to increase the number of satisfactory results.
Prognostic value of D-dimer in patients undergoing myocardial infarction in the context of a new coronavirus infection pandemic
Authors: Zamakhina Olga V. , Nikolaev Nikolaj A. , Skirdenko Juliya P. , Osipenko Elena V.
Published: February 2023

In conditions of new coronavirus pandemic and high prevalence of myocarditis, myopericarditis, the issues of differential diagnosis, especially in patients who had previously undergone myocardial infarction, appear to be relevant. Against the background of COVID-19 both recurrent acute coronary disease and myocarditis, or myopericarditis are possible, and the differential diagnosis is significantly complicated by the similarity of clinical picture (pain in the heart area (not always typical), increased titers of cardiac troponins). Particular difficulties in diagnosis arise in patients who have undergone myocardial infarction, are in a coma and have unstable hemodynamics, since the detection of zones of local hypo- or akinesis on EchoCG has no proper diagnostic value; changes on ECG can be ambiguous; and the absolute majority of hospitals that provide care to COVID-19 patients have no possibilities of making MRI with gadolinium. In such cases, additional diagnostic methods may be helpful in making a definitive diagnosis. In such cases, additional diagnostic methods may be helpful in making a definitive diagnosis. The most available and well-studied laboratory indicator is D-dimer, which is a marker of hypercoagulation syndrome, however, some scientists also considered it as a marker of necrosis in myocardial infarction. This review shows the advantages and disadvantages of D-dimer in the diagnosis of acute coronary syndrome; the possibility of its use in patients with coronavirus infection, who had previously undergone myocardial infarction; the prospects for further research on this issue are outlined. The combined use of D-dimer test with electrocardiography, echocardiography, and clinical manifestations in patients with coronavirus infection to diagnose recurrent myocardial infarction was substantiated.
Morphoscopic and morphometric characteristics of the LV-SI intervertebral disc in young and middle-aged individuals
Authors: Priymak Maksim A. , Gaivoronsky Aleksey I. , Gaivoronsky Ivan V. , Nichiporuk Gennadiy I. , Goryacheva Inga A. , Gaivoronskaya Maria G.
Published: February 2023

Objective: to study the morphoscopic and morphometric characteristics of the LV-SI intervertebral disc according to magnetic resonance imaging. Materials and methods. The analysis of magnetic resonance imaging of 90 patients (66 men, 24 women) who did not have diseases of the lumbar spine was performed. Various morphometric parameters of the intervertebral disc (IVD) and nucleus pulposus (NP) at the LV-SI level were measured using software for processing images created on an MRI machine. The obtained data were compared between men and women, asthenics, normosthenics, hypersthenics and young (from 18 to 44 years old) and middle-aged (from 45 to 60 years old) people. In addition, morphoscopic characteristics were studied: the shape of the IVD and NP in the axial plane. Results. It was found that in normal IVD LV-SI is most often represented by elliptical (54,5%) less often kidney-shaped (45,5%) forms. Normally, the NP has an oval (57,8%) and kidney-shaped (42,2%) shape. It was shown that in men, the dorsal height of the IVD, its width, anteroposterior size, square as well as the longitudinal-transverse index of the NP were significantly higher. It has been proven that there are no significant differences in the shape of the IVD between asthenics, normo- and hypersthenics, while the height of the IVD in the center, its ventral, dorsal heights and most lateral IVD height are significantly greater in hypersthenics. It has been proved that the kidney-shaped form of NP was significantly more common in asthenics, and the oval form - in hypersthenics, while the morphometric parameters of NP did not significantly differ between extreme body types. A tendency to a decrease in IVD height in middle-aged people compared to young people was shown. Conclusion. The results obtained are necessary when planning the operation, as well as for the manufacture of rigid implants and artificial discs for arthroplasty and interbody fusion.
Comparative phytochemical analysis of alchemilla vulgaris herb infusion and alchemilla mollis herb infusion
Authors: Boyarshinov Vitaly D. , Zorina Elena V.
Published: February 2023

The research data revealed the existence of various pharmacological effects of Alchemilla vulgaris herb infusions and confirmed the prospects of introducing these infusions into medical practice. Biologically active substances (BAS) in the Alchemilla herb are of high variability, which adversely affects the phytochemical composition of the infusion and its pharmacological properties. The expansion of the raw material base of Alchemilla is possible due to Alchemilla mollis, which is a micro-specie with a stable chemical composition. Objective: a comparative analysis of the phytochemical composition of infusions of A. mollis and A. vulgaris herbs to assess the possibility of expanding the raw material base of the aerial part due to the cultivated micro-specie A. mollis. Materials and Methods. The objects of the study are A. vulgaris herb infusion (AVI) and A. mollis herb infusion (AMI). The harvesting of raw materials was being produced during the period of mass flowering from cultivated Alchemilla mollis (Buuser) Rothm and wild-growing Alchemilla vulgaris L. s. I. Preliminary qualitative analysis was performed by conventional methods. The content of tannins, polysaccharides, ascorbic acid, and flavonoids were quantified. Results. A preliminary qualitative analysis showed the similarity of the studied infusions, including the presence of phenolic compounds, markers of the genus Alchemilla (caffeic acid, luteolin and quercetin derivatives). The peculiarity of AMI is the predominant content of condensed tannins, which is consistent with the data on the accumulation of this group of biologically active substances in A. mollis herb. Significant higher amounts of tannins (p<0.05) and ascorbic acid (p<0.05) were found in BAS; no differences were found in the amount of polysaccharides and flavonoids. Conclusion. The conducted study indicates the similarity of the chemical composition of the studied infusions, which allows the use of AMI similarly to AVI, and A. mollis herb to expand the raw material base of the herb.
Environmental Product and Ecolabelling Knowledge dalam Pembentukan Sikap Ramah Lingkungan
Authors:   School of Business and Economic, Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Indonesia, Hoei Amanda , Avelia Juanny ,   School of Business and Economic, Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Indonesia, Yosevina Christiana ,   School of Business and Economic, Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Indonesia, Sumarlin Antonius W. ,   School of Business and Economic, Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Indonesia
Published: February 2023

Recently, people, especially generation Z, have begun to become aware of the negative impact the fashion industry has on the environment and feel responsible for this pollution. To overcome the negative impact of the fashion industry on the environment, consumers are starting to use eco-friendly clothing and moving to the slow fashion trend. The purpose of this research is to investigate the factors that can influence the purchase of eco-friendly clothing for Generation Z in Indonesia. The conceptual basis of this research is the knowledge-attitude-behavior model and attitude-behavior-context theory. The research methodology is in the form of quantitative where the researcher collects 281 questionnaire respondents, and the data is processed using the SPSS 26 and AMOS 26 programs. From this study, ecolabelling knowledge, environmental product knowledge, green trust, environmental concern, ecolabelling desire, and environmental attitude are factors that can affect the intention to buy eco-friendly clothes in generation Z in Indonesia.
Ideal Leader Behaviour in the Workplace
Authors:   Universitas Bina Nusantara, Jl. Lingkar Bulevar Blok WA No. 1 Summarecon, Kota Bekasi – Jawa Barat, 17142, Indonesia, Miranda Bakrie Nyiayu Olivia , Chandra Gilang Rafi ,   Universitas Bina Nusantara, Jl. Lingkar Bulevar Blok WA No. 1 Summarecon, Kota Bekasi – Jawa Barat, 17142, Indonesia, Adhityatama Gemerlang ,   Universitas Bina Nusantara, Jl. Lingkar Bulevar Blok WA No. 1 Summarecon, Kota Bekasi – Jawa Barat, 17142, Indonesia, Prasetyaningtyas Sekar Wulan ,   Universitas Bina Nusantara, Jl. Lingkar Bulevar Blok WA No. 1 Summarecon, Kota Bekasi – Jawa Barat, 17142, Indonesia
Published: February 2023

Entrepreneurs in Indonesia believe that digital products and services may enable a more efficient and effective way of living. The key to achieving success in the era of digital transformation is to disrupt the market by providing consumers with exceptional value. In order to execute this correctly, businesses must be both effective and effective in achieving this expectation. Today Indonesian large businesses are digitalized and prepared to create disruptive, consumer-focused innovation as a result of this effort. In addition, as of 2022, Indonesia had the highest number of digital start-up enterprises among Southeast Asian nations, with 2,345 registered. Leadership is a factor in the success of digital firms, and digital businesses that must develop for the benefit of other companies are no exception. We believe that significant effort needs to be done in order to grasp the leadership behavior of the executives in payment aggregator firms. This research was conducted at Tangerang Indonesia-based software and consulting business. Since 2014, the company's main focus has been billing aggregation, and it currently has over 150 partners. Interviews were conducted in Indonesian, which would subsequently be translated into English for the purpose of this research. The outcomes showed that corporate leaders of a billing aggregator company have three types of behaviors that are considered desirable for their staff. Relationship-related, performance-related, and conflict-related behaviors are all interconnected. Ideal leaders establish clear boundaries not only between jobs but also between their relationships with employees.
Redes, territórios e cidades
Authors: Fialho Joaquim , Casquilho-Martins Inês
Published: February 2023

A complexidade dos problemas sociais e o contexto generalizado de incerteza coloca aos interventores sociais e aos decisores políticos um conjunto de desafios complexos face a uma realidade sistémica, em que os problemas sociais devem ser considerados de forma integrada e holística. Este artigo tem como objetivo analisar o diagnóstico da rede de ação social da Área Metropolitana de Lisboa (Portugal), sistematizando as principais problemáticas identificadas neste território. A abordagem metodológica deste estudo recorreu à Social Network Analysis para mapear as lógicas de interação nos domínios de intervenção da rede social da Área Metropolitana de Lisboa, tendo por base os diagnósticos sociais existentes. A partir deles foram identificadas diversas dinâmicas da rede e a sua relação com o território. Posteriormente, optámos por centrar a análise na ação social e, a partir daí, proceder ao tratamento de dados através de análise de conteúdo categorial. Este processamento dos dados conduziu à sistematização de resultados quanto às problemáticas diagnosticadas como eixos de atuação prioritária. Verificou-se que os municípios da Área Metropolitana de Lisboa necessitam de um maior reforço na atualização periódica do diagnóstico do território, em particular num período em que assiste à transferência de competências de ação social do Estado Central para o Poder Local. Consequentemente, é necessário um envolvimento mais participado dos diferentes parceiros da Rede Social destes territórios, para que efetivamente se possa detetar, prevenir e atuar perante os problemas e necessidades sociais prioritários, visando à promoção dos recursos e potencialidades da rede para um melhor desenvolvimento social e local.
Targeting Ion Channels for the Treatment of Glioma
Authors: Keluth Saritha , Jitte Srikanth , Bhushan Rashmi , Ranjan Om Prakash , Murti Krishna , Ravichandiran Velayutham , Kumar Nitesh
Published: February 2023

Background:

Glioma refers to the most aggressive tumor in the central nervous system that
starts from support cells or glial cells. The glial cell is the most common cell type in the CNS, and
they insulate, surround, as well as feed, oxygen, and nutrition to the neurons. Seizures, headaches,
irritability, vision difficulties, and weakness are some of the symptoms. Targeting ion channels is particularly
helpful when it comes to glioma treatment because of their substantial activity in glioma genesis
through multiple pathways.

Objective:

In this study, we explore how distinct ion channels can be targeted for glioma treatment
and summarize the pathogenic ion channels activity in gliomas.

Results:

Current research found several side effects such as bone marrow suppression, alopecia, insomnia,
and cognitive impairments for presently done chemotherapy. The involvement of research on
ion channels in the regulation of cellular biology and towards improvements of glioma have expanded
recognition of their innovative roles.

Conclusion:

Present review article has expanded knowledge of ion channels as therapeutic targets and
detailed cellular mechanisms in the roles of ion channels in gliomas pathogenesis.
Polycaprolactone-based Nanocarriers Containing 5-fluorouracil as a
Therapeutic Guided Drug Delivery Approach for Enhancing Anticancer
Activity
Authors: Mohammadian Samaneh , Khazaei Majid , Maghami Parvaneh , Avan Amir , Rezaei Majid
Published: February 2023

Nowadays, nano-platforms designed for drug delivery systems (DDSs) such as polymers,
liposomes, and micelles have been demonstrated to be clinically efficient. The sustained drug release is
one of the advantages of DDSs, especially polymer-based nanoparticles. The formulation could enhance
the drug's durability, in which the biodegradable polymers are the most interesting building
blocks of DDSs. Nano-carriers could circumvent many issues by localized drug delivery and release
via certain internalization routes such as intracellular endocytosis paths and increasing biocompatibility.
Polymeric nanoparticles and their nanocomposite are one of the most important classes of materials
that can be used for the assembly of nanocarriers that can form complex, conjugated and encapsulated
forms. The site-specific drug delivery may arise from the ability of nanocarriers to pass through the
biological barrier, their specific interactions with receptors, and passive targeting. The better circulation,
uptake, and stability along with targeting attributes lead to lesser side effects and damage to normal
cells. Hence, in this review, the most recent achievements on polycaprolactone-based or -modified
nanoparticles in drug delivery systems (DDSs) for 5-fluorouracil (5-FU) are presented.
Electrochemical Detection of Sulfadiazine by Sensors based on Chemically
Modified Carbon Electrodes: A Review
Authors: Ben Brahim Khalid Ait , Bendany Mohamed , El Hamdouni Youssra , Abbi Khaoula , Bakkouche Chaymae , Fattoumi Hatim , Hermouche Lina , Labjar Najoua , Dalimi Mohamed , El Hajjaji Souad
Published: February 2023

The consumption of medicines (usually pharmaceuticals and chemical health products)
has increased in recent decades due to the demand for medicines for various diseases (headache,
relapsing fever, dental absence, streptococcal infection, bronchitis, ear and eye infections). Instead,
their overuse can lead to serious environmental damage. Sulfadiazine is one of the most often used
antimicrobial medications for both human and veterinary therapy, yet its presence in the
environment, even in low quantities, offers a potential concern as an emergency pollutant. It is vital
to have a monitoring that's quick, selective, sensitive, stable, reversible, reproducible, and easy to
use. Electrochemical techniques realizing cyclic voltammetry (CV), differential pulse voltammetry
(DPV), and square wave voltammetry (SWV), using a modified electrode based on carbon as a
surface modifier are an excellent option that makes control simple and quick owing to their cheap
cost and convenience of use, while also safeguarding human health from drug residue buildup.

:

This study discusses different chemically modified carbon-based electrodes such as graphene paste,
screen printed electrode, glassy carbon, and boron diamond doped electrodes for SDZ (sulfadiazine)
detection in various formulation feeds, pharmaceuticals, milk, and urine samples, the results
obtained also show high sensitivity and selectivity with lower detection limits compared to matrix
studies, which may explain its use in trace detection. Furthermore, the effectiveness of the sensors is
assessed by other parameters including buffer solution, scan rate, and pH. Also, a method for real
sample preparation was also discussed in addition to the different methods mentioned.
Childhood Trauma and Self-harm in Youths with Bipolar Disorders
Authors: Janiri Delfina , Di Luzio Michelangelo , Montanari Silvia , Hirsch Daniele , Simonetti Alessio , Moccia Lorenzo , Conte Eliana , Contaldo Ilaria , Veredice Chiara , Mercuri Eugenio , Sani Gabriele
Published: February 2023

Background:

Bipolar disorders (BD) in youth are associated with a high risk of self-harm
behaviors. Childhood trauma (CT) is a relevant environmental stressor that is related to both BD diagnosis
and self-harm in adulthood. It is not yet established whether CT may impact self-harm risk in
youth. Therefore, the aim of this study was to investigate the distribution patterns of CT in youth BD
with and without self-harm.

Methods:

We assessed 273 participants (aged 13-25 years), 96 youths with BD according to DSM-5
criteria and 177 healthy controls (HC). History of CT was obtained using the Childhood Trauma Questionnaire
(CTQ). The association between CT and self-harm was tested using multivariate statistical
models.

Results:

Over 45% of participants with BD reported lifetime self-harm. The BD Self-harm group reported
more emotional abuse, emotional neglect, sexual abuse, and physical abuse than HC. The BD
No-Self-harm group reported more emotional abuse than HC. The BD Self-harm group reported more
emotional abuse and neglect than the BD No-Self-harm group. The BD Self-harm group also reported
separated parents, hospitalizations, smoking, use of antiepileptics, antipsychotics and lithium. Emotional
abuse was an independent predictor of self-harm in youths with BD.

Conclusions:

Findings support the importance of assessing CT, in particular emotional abuse, in youth
with BD at risk for self-harm.
Antinuclear Antibody Seropositivity in Fibromyalgia Associated with Borrelia-specific T Lymphocytes
Authors: Puri Basant K. , Lee Gary S. , Schwarzbach Armin
Published: February 2023

Background:

Our group have recently reported that there is no evidence of an associa-tion between fibromyalgia and Borrelia-specific T lymphocytes. However, a small number of case reports has suggested that infection by the bacterial genus Borrelia may be associated with the pres-ence of antinuclear antibodies (ANAs).

Objective:

To test the hypothesis that those fibromyalgia patients who are ANA seropositive are more likely to show evidence of Borrelia-specific T lymphocyte reactivity than those who are sero-negative.

Methods:

T lymphocyte reactivity to Borrelia burgdorferi sensu stricto (full antigen) was assessed using the enzyme-linked immunospot and serum ANA status was assessed using immunofluores-cence in 27 fibromyalgia patients fulfilling the revised diagnostic criteria of the American College of Rheumatology.

Results:

The ANA seropositive and seronegative groups were matched for age, sex and ethnicity; the T lymphocyte reactivity to Borrelia burgdorferi sensu stricto (full antigen) in the former group (mean 5.60) was significantly higher than that in the seronegative group (mean 1.77; p < 0.05).

Conclusion:

This novel study points to an association of ANA seropositivity in fibromyalgia with Borrelia-specific T lymphocytes.
Current Trends and Prospective Role of Flavonoids and Flavones as Anticancer
Agents: A Review
Authors: Sharma Rupali , Sapra Kavita , Samamadar Suman , Sapra Ashu , Kumar Virender
Published: February 2023

Background:

Among the leading causes of death, cancer is second to heart disease as
a group of diseases. It has been found that several natural substances, including flavonoids, can
treat cancer in addition to several types of chemotherapy.

Objective:

Flavonoids are naturally occurring polyphenolic compounds with no or minimal toxicity,
and have been utilized by people since ancient times. They produce several special therapeutic
effects, such as anti-inflammatory, immune response modulating, and antioxidant effects,
thereby supporting normal cellular functions. Flavonoids can be classified into six major subtypes
or groups based on the degree of oxidation, chemical structure, and unsaturation in the
linking chain. Aside from flavonoids and flavanones, flavonols, flavonols, flavones, and anthocyanids
also fall into these categories.

Methods:

In order to find studies on flavonoids as anticancer agents, we searched Science Direct,
Google Scholar, PubMed, Wiley Online Library, Springer, and Medline databases.

Results:

The enhanced generation of reactive oxygen species (ROS) in the electron transport
chain due to oxidative stress leads to inflammation, the development of many degenerative diseases,
cancer, etc. Oxidative stress can be relieved by flavonoids because they regulate ROS homeostasis
(scavenging ROS), trigger apoptosis, and suppress prooxidant enzymes during oxidative
stress.

Conclusion:

Here we review the structure and classification of flavonoids and their mechanisms
of action as anticancer agents as well as the challenges involved in developing flavonoids to fight
cancer.
Predicting Severe COVID-19 Infection on Initial Diagnosis: Comparison
and Validation of CT Imaging Triage Tools
Authors: Kurban Lutfi Ali S , Abu Sa’a Maysam , Ahmed Farghal Aser Soliman , Aby Ali Hussain Ali , Syed Rizwan , Al Zwae Khaled
Published: February 2023

Background:

Developing a reliable predictive tool of disease severity in COVID-19 infection
is important to help triage patients and ensure the appropriate utilization of health-care resources.

Objective:

To develop, validate, and compare three CT scoring systems (CTSS) to predict severe disease
on initial diagnosis of COVID-19 infection.

Methods:

One hundred and twenty and 80 symptomatic adults with confirmed COVID-19 infection
who presented to emergency department were evaluated retrospectively in the primary and validation
groups, respectively. All patients had non-contrast CT chest within 48 hours of admission. Three lobarbased
CTSS were assessed and compared. The simple lobar system was based on the extent of pulmonary
infiltration. Attenuation corrected lobar system (ACL) assigned further weighting factor based on
attenuation of pulmonary infiltrates. Attenuation and volume-corrected lobar system incorporated further
weighting factor based on proportional lobar volume. The total CT severity score (TSS) was calculated
by adding individual lobar scores. The disease severity assessment was based on Chinese National
Health Commission guidelines. Disease severity discrimination was assessed by the area under
the receiver operating characteristic curve (AUC).

Results:

The ACL CTSS demonstrated the best predictive and consistent accuracy of disease severity
with an AUC of 0.93(95%CI:0.88-0.97) in the primary cohort and 0.97 (95%CI:0.91.5-1) in the validation
group. Applying a TSS cut-off value of 9.25, the sensitivities were 96.4% and 100% and the specificities
were 75% and 91% in the primary and validation groups, respectively.

Conclusion:

The ACL CTSS showed the highest accuracy and consistency in predicting severe disease
on initial diagnosis of COVID-19. This scoring system may provide frontline physicians with a triage
tool to guide admission, discharge, and early detection of severe illness.