bluuebunny/crossref_metadata_2025 huggingface dataset:
Anatomical changes induced by isolates of Trichoderma spp. in soybean plants
Authors: Oliveira Camilla Martins , Almeida Nayane Oliveira , da Rocha Mara Rubia , Rezende Maria Helena , Carneiro Renê Gonçalves da Silva , Ulhoa Cirano José
Published: November 2020

In the current work we evaluated the anatomical changes induced by T. harzianum and T. asperellum in two soybean cultivars, BRSGO Caiaponia and NA 5909 RG. Soybean production represents a growing market worldwide, and new methods aimed at increasing its productivity and yield are constantly being sought. Fungi of the genus Trichoderma have been widely used in agriculture as a promising alternative for the promotion of plant growth and for biological control of various pathogens. It is known that Trichoderma spp. colonize plant roots, but the anatomical changes that this fungus can cause are still less studied. Experiment was conducted in a greenhouse to collect leaves and soybean roots to perform analysis of growth parameters, enzymatic activity of defense-related enzymes and anatomical changes. It was observed that inoculation of Trichoderma spp. caused anatomical alterations, among them, increase in stomatal index at the abaxial leaf surface, thickness of the root cortex, thickness of adaxial epidermis, mean diameter of the vascular cylinder, thickness of the mesophyll, and thickness of the spongy parenchyma of the soybean plants. These results indicate that the alterations in these factors may be related to the process of plant resistance to pathogens, and better performance against adverse conditions. This study demonstrates that the anatomical study of plants is an important tool to show the effects that are induced by biological control agents.
Bactericidal activity of skin mucus and skin extracts of Catla catla and Channa striatus
Authors: Ranjini Shanmugavel , Muniasamy Samuthirapandi , Rameshkumar Ganesan , Rajagopal Thangavel , Sivakumar Thangavel , Ponmanickam Ponnirul
Published: November 2020

Fishes counteract certain microbial attacks in water by producing antimicrobial proteins/peptides in their skin surface. The present study focused on screening the bactericidal activity of skin and skin mucus extracts of Catla catla and Channa striatus. The bactericidal activity was assessed against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus vulgaris, Aeromonas hydrophila, Staphylococcus aureus and Bacillus coagulans by disc diffusion method. The minimal inhibitory concentration was also determined. Protein profiles in skin and skin mucus extracts were analyzed by SDS-PAGE. Samples from both fishes showed antibacterial activity. Detailed analysis of individual protein and peptide would throw light on their medicinal importance to be used against pathogenic microbes.
PhD Abstracts
Authors: Vágvölgyi Csaba
Published: November 2020

Abstracts of the Annual Conference of Doctoral School of Biology, University of Szeged – 2020.
A experiência da reorganização da Atenção Primária à Saúde – APS e trabalho dos agentes comunitários de saúde frente à COVID-19 em um município no interior do Amazonas
Authors: Menezes da Mata Mayline , Nascimento de Castro Daiane , Araújo Gomes Cléber , Alves de Macêdo Juliberta , Helena Ribeiro De Checchi Maria , Santiago Muri Gama Abel , Paulo Souza e Souza Luís
Published: November 2020

A COVID-19 atingiu o Amazonas, ampliando as vulnerabilidades que já existiam, principalmente nas cidades do interior. Considerando o importante papel que a Atenção Primária à Saúde – APS tem diante da atual pandemia, além do fato de que maior parte dos serviços de saúde nos municípios do interior do estado é ofertada pela APS, buscou-se descrever a experiência da reorganização da APS, com ênfase nas ações dos agentes comunitários (AC) de um município do interior do Amazonas. Coari está localizado na mesorregião Centro Amazonense, cujo acesso é por via fluvial e aérea, a 363 quilômetros da capital, Manaus. Até o dia 12 de setembro de 2020, o município ocupava a segunda posição no estado com maior número de casos (n=6.990); e terceiro em número de óbitos (n=105). Dispõe de 223 ACS, integrando 22 equipes da Estratégia Saúde da Família e três Núcleos Ampliados de Saúde da Família e Atenção Básica. Na pandemia, 35 ACS foram afastados por estarem nos grupos de risco. Destaca-se que os ACS da zona urbana e rural (incluindo as comunidades ribeirinhas) incorporaram ao seu rol de atividades ações de monitoramento dos casos confirmados e suspeitos, por meio de visitas domiciliares ou remotamente (por celular). Destacam-se os desafios advindos das barreiras geográficas e de sinal telefônico, características das moradias (alta densidade domiciliar), elevadas prevalências de outras doenças comuns na região, e deficiência de profissionais de nível superior nas unidades da zona rural/ribeirinha. Contudo, mesmo com os desafios, os ACS têm sido atores estratégicos para o enfrentamento da pandemia em Coari, atuando na organização do serviço e na continuidade do cuidado. Estratégias que fortaleçam a APS, colocando-a no centro das discussões, priorizando recursos para seu financiamento e reconhecendo o protagonismo dos ACS, são essenciais para o sucesso do enfrentamento à COVID-19 no país, principalmente nos municípios do interior.
Auxílio emergencial no contexto de pandemia da COVID-19
Authors: Correia Daniele , Fernanda dos Santos Aila , Paula do Amaral Brito Kelly , Dias da Silva Guerra Lúcia , José Vieira Kleber , Leci de Souza Rezende Cynthia
Published: November 2020

O presente artigo aborda a discussão sobre o benefício financeiro de auxílio emergencial destinado para a classe trabalhadora no presente período de crise sanitária mundial e brasileira, atrelada à crise do capital que se intensificou pela pandemia de COVID-19. Para tanto, este artigo de debate se constitui em três momentos. Na primeira parte realizamos um debate sobre o papel das políticas sociais, situando-as no contexto histórico. Na segunda parte, apontamos a forma como o benefício do auxílio emergencial está sendo implementado no Brasil e quem são os setores que mais se beneficiam dessa proposta, bem como, quem são os sujeitos mais afetados pela crise, compreendo que os aspectos estruturantes de gênero, raça/etnia nos informam quem é a classe trabalhadora brasileira. Na terceira parte realizarmos um balanço crítico sobre o auxílio emergencial enquanto proteção social. Conclui-se que, embora o auxílio emergencial seja fruto de reivindicações da classe trabalhadora, o mesmo possui intrínsecas contradições ao passo que também atende os interesses da reprodução do capital e, não uma real garantia de proteção social.
Caracterização dos óbitos por malformações congênitas no sistema nervoso entre 2000 e 2017 no Brasil
Authors: Sousa Cavacante Mateus , Galindo Silva Gláucia , Santos Rocha Érica , Barbosa da Silva Jardel , Rocha Coimbra Thayná , Cristhyan Alves Carvalho Allan , Luciano Carneiro Alves de Oliveira Bruno
Published: November 2020

No Brasil, distúrbios genéticos são a segunda maior causa de mortalidade infantil, e os defeitos do sistema nervoso (SN) correspondem a 18,8% deles. Este estudo buscou caracterizar os óbitos por Malformações Congênitas no Sistema Nervoso – MCSN entre 2000 e 2017 no Brasil. Trata-se de estudo transversal com dados de óbitos por MCSN de 2000 a 2017. Foram analisadas as variáveis idade, sexo e cor/raça do óbito da criança, e a idade, escolaridade e tipo de parto da mãe, região do país, e quais as principais malformações. Diferenças estatísticas foram verificadas por meio do teste de Qui-quadrado de Pearson e consideradas significantes quando o p-valor <0,05. No período avaliado, foram registrados 29.641 óbitos por MCSN e o número de casos vem reduzindo. A hidrocefalia foi a causa mais frequente, seguida da microcefalia. Óbitos relacionados à microcefalia tiveram pico súbito de crescimento durante o período de epidemia do Zika. A maioria dos casos de óbitos por microcefalia nos anos analisados (86,0%) foram em crianças menores de um ano de idade. As variáveis sociodemográficas: sexo, raça e região demonstraram-se estatisticamente significantes (p-valor<0,05). A região Sudeste apresentou maior proporção (34,8%), seguido do Nordeste (30,4%). A maioria dos óbitos foi em meninas (52,1%), brancos (56,0%) e nasceram de parto cesáreo (64,1%). Predominaram casos em mães na faixa etária de 19 a 35 anos (74,6%), seguido de mães mais jovens (19 anos = 17,1%). Também houve predominância de casos quando a mãe possuía escolaridade de 4 a 11 anos (72,1%). Observou-se que ainda há grande ocorrência de óbitos por MCSN e estes ainda são maiores que outros países. Esses dados podem refletir a baixa adesão ao pré-natal e cuidados gestacionais, assim como geram questões importantes sobre ao desenvolvimento infanto-juvenil no país.
Modelagem das operações de um terminal retroportuário de contêineres para maximização da margem de contribuição
Authors: Bilinski Patrícia Aparecida , Isler Cassiano Augusto , Costa Gustavo
Published: November 2020

Os terminais retroportuários de contêineres surgiram para colaborar com a manutenção dos portos marítimos de contêineres no mercado global. Dado que as operações naqueles terminais devem ser planejadas para maximizar o seu retorno financeiro, este artigo apresenta um modelo matemático de programação linear inteira para determinação do número de operações que maximiza a margem de contribuição de um terminal retroportuário. O modelo considera diferentes operações nas suas áreas específicas e o atendimento de múltiplos produtos por diferentes tipos de contêineres em um horizonte de planejamento. Diferentes cenários foram estabelecidos em uma aplicação no contexto de um terminal retroportuário em Itapoá-SC. A máxima margem de contribuição entre os cenários foi obtida ao segregar a commodity madeira em dois produtos específicos, serrada e compensada, sendo este o material mais rentável. O segundo cenário de máxima margem de contribuição foi pelo aumento de um turno na oficina de reparo de contêineres.
ADDITIVE LASER BARCODE PRINTING ON HIGH REFLECTIVE STAINLESS STEEL
Authors: Mihalev Mihail Stoyanov , Hardalov Chavdar Momchilov , Christov Christo Georgiev , Rinke Monika , Leiste Harald , Schneider Johannes
Published: November 2020

In this paper, the process of an additive laser marking on stainless steel parts for barcode printing is presented. It is based on the use of one transition metal oxide chemically-well bonded to the stainless steel substrate, without a usage of any additional materials and cleaning substances.
The resulting additive coatings, produced from initial MoO3 powder by irradiation with a laser beam, reveal strong adhesion, high hardness, long durability and high optical contrast, which make the process suitable for barcode printing on materials such as high reflective stainless steel, which was always a challenge for the classical laser marking technologies.
The obtained bar patterns are in a compliance with the requirements of the existing standards.
APPLICATION OF FMEA METHODOLOGY FOR CHECKING OF CONSTRUCTION’S PROJECT DOCUMENTATION AND DETERMINATION OF THE MOST RISK AREAS
Authors: Tuháček Martin , Franek Ondřej , Svoboda Pavel
Published: November 2020

The article deals with an innovative method designed to check project documentation of buildings at the design stage, specifically exploring the possibility to implement FMEA and PDCA methodologies. Based on performed measurements and data collection, it theoretically determines the riskiest areas of the project documentation, which should be given special attention in order to reduce later costs for construction companies to fix the reported complaints. The research proves that the application of the FMEA and PDCA methodology can be very useful regarding the elimination of defects in the project documentation of constructions already in the phase of construction preparation.
La vinculación con el medio en la Universidad de Santiago de Chile. El alcance territorial de los proyectos financiados entre 2018 y 2020
Authors: Salazar Alvarado Diego
Published: November 2020

El presente trabajo describe el alcance territorial de las acciones de vinculación con el medio de la Universidad de Santiago de Chile en la Región Metropolitana desde su programa de financiamiento de proyectos. Para ello se emplea la información obtenida a partir de los proyectos financiados por el Fondo VIME entre el año 2018 y 2020. De los resultados, se identifica una mayor presencia de relaciones en el entorno inmediato a la universidad y una menor presencia en lugares que presentan un mayor índice de prioridad social. El trabajo propone algunos elementos a considerar a la hora de medir o evaluar la función universitaria estudiada, además de abrir el debate en torno a la relación entre la universidad y el contexto social actual.
NARASI GERBANG RUMAH PERANAKAN DI PECINAN, LASEM, JAWA TENGAH: PENDEKATAN FENOMENOLOGI
Authors: Darmayanti Tessa Eka , Bahauddin Azizi
Published: November 2020

The gate is an important component of Peranakan houses in Lasem. They are included in the cultural heritage of Indonesia, and most of them are more than a hundred years old, but still stand firm and lined up neatly adorning the Pecinan area. The purpose of this paper is to provide a different perspective on the existence of the Peranakan houses’ gates that interpreted through the author’s experiences during the fieldwork. The gate embodiment gives a different atmosphere and experience which is not found elsewhere because they are unique and irreplaceable. Unfortunately, preserving these gates become a serious challenge in the modern era. The finding comes from the phenomenon which found after the field research and analyzed using the phenomenology approach of Merleau Ponty, Juhani Pallasmaa, and Steven Holl. Phenomenology allows people to express their existence through architecture and let its value appear to people as they experience it. The result showed that experiences would give the people have an attachment to the place unconsciously.
Boundary value problems associated with singular strongly nonlinear equations with functional terms
Authors: Biagi Stefano , Calamai Alessandro , Marcelli Cristina , Papalini Francesca
Published: November 2020

We study boundary value problems associated with singular, strongly nonlinear differential equations with functional terms of type

(Φ(k(t)x′(t)))′+f(t,Gx(t))ρ(t,x′(t))=0,$$\big({\it \Phi}(k(t)\,x'(t))\big)' + f(t,{{\mathcal{G}}}_x(t))\,\rho(t, x'(t)) = 0,$$

on a compact interval [a,b]. These equations are quite general due to the presence of a strictly increasing homeomorphismΦ, the so-calledΦ-Laplace operator, of a non-negative functionk, which may vanish on a set of null measure, and moreover of a functional term Gx. We look for solutions, in a suitable weak sense, which belong to the Sobolev spaceW1,1([a,b]). Under the assumptions of the existence of a well-ordered pair of upper and lower solutions and of a suitable Nagumo-type growth condition, we prove an existence result by means of fixed point arguments.
Radioiodination and biological evaluation of Cimetidine as a new highly selective radiotracer for peptic ulcer disorder detection
Authors: Sanad Mahmoud H. , Challan Safaa B. , Marzook Fawzy A. , Abd-Elhaliem Sayed M. , Marzook Ebtisam A.
Published: November 2020

One of the most famous techniques for stomach ulcer imaging is the nuclear imaging technique. We aim to focus on the synthesis of125I-cimetidine (125I-cim) as an agent for peptic ulcer imaging. Cimetidine was labeled with Iodine-125 using a different oxidizing agent (Ch-T, NBS). All factors affecting the labeling yield were optimized. The radiochemical yield of125I-cim was 98 ± 0.22% at optimum conditions.In vitrostability,in vivobiodistribution of125I-cimetidine was studied in three groups: control group, pretreated group, and ulcer bearing group.In vivobiodistribution studies of125I-cim revealed high uptake in the stomach ulcer, reaching about 75.4 ± 1.2% ID/g at 15 min post-injection, than pretreated groups compared to the control. The results showed the suitability of using125I-cimetidine for stomach ulcer imaging.
Queering Musical Biography in the Writings of Edward Prime-Stevenson and Rosa Newmarch
Authors: Franseen Kristin M.
Published: November 2020

Beginning with the “open secret” of Benjamin Britten and Peter Pears's relationship and continuing through debates over Handel's and Schubert's sexuality and analyses of Ethel Smyth's memoirs, biography has played a central role in the development of queer musicology. At the same time, life-writing's focus on extramusical details and engagement with difficult-to-substantiate anecdotes and rumors often seem suspect to scholars. In the case of early-twentieth-century music research, however, these very gaps and ambiguities paradoxically offered some authors and readers at the time rare spaces for approaching questions of sexuality in music. Issues of subjectivity in instrumental music aligned well with rumors about autobiographical confession within Tchaikovsky's Symphony No. 6 (Pathétique) for those who knew how to listen and read between the lines. This article considers the different ways in which the framing of biographical anecdotes and gossip in scholarship by music critic-turned-amateur sexologist Edward Prime-Stevenson and Tchaikovsky scholar Rosa Newmarch allowed for queer readings of symphonic music. It evaluates Prime-Stevenson's discussions of musical biography and interpretation in The Intersexes (1908/9) and Newmarch's Tchaikovsky: His Life and Works (1900), translation of Modest Tchaikovsky's biography, and article on the composer in Grove's Dictionary of Music and Musicians to explore how they addressed potentially taboo topics, engaged with formal and informal sources of biographical knowledge (including one another's work), and found their scholarly voices in the absence of academic frameworks for addressing gender and sexuality. While their overt goals were quite different—Newmarch sought to dismiss “sensationalist” rumors about Tchaikovsky's death for a broad readership, while Prime-Stevenson used queer musical gossip as a primary source in his self-published history of homosexuality—both grappled with questions of what can and cannot be read into a composer's life and works and how to relate to possible queer meanings in symphonic music. The very aspects of biography that place it in a precarious position as scholarship ultimately reveal a great deal about the history of musicology and those who write it.
Рerspectives of world potential development electronic logistics market
Authors:   Mariupol State University, Omelchenko Volodymyr , Omelchenko Ganna ,   Mariupol State University, Omelchenko Oleksandra ,   LLC "Finance"
Published: November 2020

The aim of the article. The article emphasizes that the transformations taking place in the modern world economy under the influence of accelerating scientific and technological progress, processes of informatization, globalization and regionalization have led to the formation of new approaches and methods of doing business. The results of the analyses. The global world is constantly advancing to the information-innovation era, the network economy, in which most business becomes electronic and is carried out on the Internet on the basis of information and communication technologies (ICT). Complications of foreign economic relations due to the intensification of competition in world markets determine the need to develop new mechanisms to ensure the sustainable development of global e-business. The implementation of the information society development strategy in the world's leading countries (USA, Japan, Germany, etc.) shows that one of such priority tools for the growth of the e-commerce market is its gradual logistics. Conclusions and perspectives for further research. Due to the generalization of modern directions of world development e-logistics market (its further consolidation through a system of mergers and acquisitions; creation of international research and production alliances to develop new software products for e-logistics; rapid growth of the potential of the mobile commerce segment; expanding the scope of commercial services provided to consumers worldwide network) developed and substantiated a system of mechanisms for sustainable development of international and national electronic logistics markets, the basic basis of which is the strategic interaction and interdependence of institutional, innovation and technological, marketing, infrastructure and logistics and financial and economic transformations. This makes it possible to create an analytical basis for assessing the development of its individual segments in terms of effective integration of the country into the global market for electronic logistics. Keywords: world electronic logistics market, mechanisms of e-logistics, structural transformations, sustainable development of e-logistics.
Modeling of Economic Convergence Processes in Eastern Europe Countries
Authors: Stavytskyy Andriy V. , Kozub Maryna B.
Published: November 2020

The article describes the features of the processes of economic convergence in the countries of Eastern Europe for the last 10 years. The analysis of β- and σ-convergence was carried out based on a system of macroeconomic indicators with 10 key parameters. The calculation of the direction and speed of convergence was performed using the econometric instruments in the region as a whole and pairwise analysis of the β-convergence index for all analyzed countries. The obtained results allowed to conclude the inequity development of Eastern European countries and the lack of a stable trend towards convergence of macroeconomic indicators. The resulting model is universal and can be applied to other world regions or to determine the processes of convergence of another system of macroeconomic indicators and choose main directions of reforming to bring national economies closer and achieve stronger external relations.
An Assessment of House Loans Cointegration with Macro Variables in Selected Euro Zone Countries
Authors: Kupčinskas Kazys , Paškevičius Arvydas
Published: November 2020

This paper performs an empirical study on house loans, interest rates, unemployment, and house rent prices relationship in Germany, France, Spain and Italy from the year 2003 to 2018. We look for the cointegration and causality relationship between the house loans and macro variables with the help of the Vector error correction model (VECM) and Granger causality methods. We investigate whether variables with monthly data explain better the relationship and causal effects between the variables. We find a long term cointegrating relationship between the real house loans and interest rates, unemployment and house rent prices for France, Spain, and Italy, but not for Germany. On average the equilibrium in house loan development is reached from 4 to 8 years, meaning that long term equilibrium exists, but the variables reach it in a rather long time period. The ECB deposit facility rate included as an exogenous variable in four countries gained no significant power in explaining the short term changes of house loans in any of the country. We reveal a complex interaction between the bank’s credits and unemployment, interest rates, house rental prices in the paper.
Isabella Abbonizio: Musica e colonialismo nell'Italia fascista (1922-1943)
Authors: Abbonizio Isabella
Published: November 2020

Dissertation Abstract
Moving to Map and Mapping to Move: The East Africa Colonial Itineraries of the IGMI Archives and Library as a Special Genre in Cartography
Authors: Ciampi Gabriele
Published: November 2020

Colonial Itineraries represent an informative product that has its origins in the innovative military organization of Revolutionary and Napoleonic France. Italian Colonial Itineraries were the outcome of exploration and intelligence activities carried out by selected military units in unknown lands. The knowledge of the places was an essential precondition of conquest and its stabilization. The major feature of the itineraries is the juxtaposition of a reconnaissance map to a list of detailed information concerning every short stretch of route covered: running times, road conditions, climate, landforms, land-use, water resources, culture, economy, monuments, etc. The Archives and the Library of the IGMI (Istituto Geografico Militare Italiano), set in Florence, preserve a great deal of such documents and they are probably the richest Italian stock. Itineraries represent a valuable source of geographical knowledge about Ethiopia and Eritrea during the period between the late nineteeth and the thirties of the twentieth century. These pages are the result of an attempt at census and interpretation.
Éloi Ficquet and Wolbert G.C. Smidt, eds, The Life and Times of Lïj Iyasu of Ethiopia: New Insights
Authors: Ancel Stéphane
Published: November 2020

Review
Abbas H. Gnamo, Conquest and Resistance in the Ethiopian Empire, 1880–1974: The Case of the Arsi Oromo
Authors: Girke Felix
Published: November 2020

Review
Text Emendations in Ethiopic Manuscript NLM 27 (National Archives and Library Agency, Addis Abeba)
Authors: Demissie Yosef
Published: November 2020

The paper investigates the phenomenon of textual corrections in Ethiopic manuscripts at the example of some cases documented in the collection of the National Archives and Library Agency, Addis Abeba. The case-study of the MS NLM 27 (Pauline Epistles) is presented more in detail.
Parent's motivations on sports participation of their children with Downâ€™s syndrome in Russia
Authors: Makhov A.S. , Medvedev Ilya Nikolayevich
Published: November 2020

Background: Regular physical exercises can improve physical and mental health and especially important for individuals with extensive disorders, such as Downâ€™s syndrome. For the success of rehabilitation, it is necessary to involve the parents of children with Downâ€™s syndrome in the process. By understanding the parents' motivation, a successful training program will be possible.Aim: This study is aimed to determine the importance degree of various parentsâ€™ motivations in sports participation of their children with Downâ€™s syndrome.Method: A survey was conducted in 137 families from 22 regions of Russia in November 2016. The survey included 23 motivational statements and parents were asked to rate the importance of each statement on a scale of 1 to 10. The results were divided into 5 groups based on the importance of the motivational statements: â€œabsolutely importantâ€, â€œimportantâ€, â€œdifficult to sayâ€, â€œnot importantâ€, and â€œabsolutely not importantâ€. Statistical analysis was done using average values method. Result: Parents considered the following reasons to let their children participate in sports as â€œabsolutely importantâ€: to implement healthy and active lifestyle; to develop interaction skills in a group, independence, and dexterity; to improve the skills of large-scale body movements and coordination of movements; and to encourage socialization. None of the motivational statements were considered as â€œabsolutely not importantâ€.Conclusion: This study found that parents considered the majority of the motivational statements as important. Considering the parentsâ€™ motives will encourage the sports participation of children with Downâ€™s syndrome.
A cross-sectional study: The correlation of pro-angiogenic factors expression level and epithelial ovarian cancer staging
Authors: Prakosa Teguh , Mudigdo Ambar , Purwanto Bambang , Wasita Brian , Cilmiaty Risya , Widianingsih Vitri
Published: November 2020

Background: Cancer is caused by uncontrolled cell growth and angiogenesis as a vital component in tumor growth and metastasis. Angiogenesis provides nutrients needed by cancer cells in order to grow. Angiogenesis is triggered by pro-angiogenic mediators and overexpression of these mediators have been associated with malignant phenotype of ovarian cancer. It is thought that the more advanced tumors have higher tumor cell survival, proliferation, invasion, and angiogenesis, so that it will show higher expression of pro-angiogenesis mediators.Objective: To examine the differences in nerve growth factor (NGF), tyrosin kinase receptor A (TrkA), and vascular endothelial growth factor (VEGF) expression level in different stages of epithelial ovarian cancer.Patients and methods: This is a retrospective cross-sectional study conducted from June to August 2019 in the Department of Obstetrics and Gynecology in association with the Department of Anatomic Pathology of Dr. Moewardi General Hospital, Surakarta, Indonesia. The staging of the epithelial ovarian cancer was determined using the FIGO 2014 staging system. NGF, TrkA, and VEGF expression level were determined using immunohistochemical examination.Results:The samples were 53 formalin-fixed, paraffin-embedded ovary, its adnexa, uterus, and lymph nodes tissue blocks of epithelial ovarian cancer patients. There are statistically significant differences in the proportion of NGF, TrkA, and VEGF level of expression in different stages of epithelial ovarian cancer (p<0.05).Conclusion: There are statistically significant differences in NGF, TrkA, and VEGF level of expression in different stages of epithelial ovarian cancer.
Wana Seraya Nursing Home (WSNH) integrated services to establish healthy and happy elderly: a qualitative study
Authors: Ariani Ni Ketut Putri
Published: November 2020

Background. The increasing number of elderly people in Indonesia reflects the success in various aspects of service, but on the other hand, these conditions have brought about the consequences of various social problems among the elderly such as physical, spiritual, social, and economic deterioration.Method. The qualitative study was conducted in April 2019.Result. Wana Seraya Nursing Home was founded in 1975 with the aim of developing the nursing home as a service center, guidance and information on social welfare for the elderly. The activities of the elderly include mental/spiritual guidance, exercise, recreation, and routine health services. Received the elderly who were escorted by their family and who were found neglected.Conclusion. Various social and cultural aspects are the reasons for living in a nursing home, and with integrated services, the elderly feel comfortable and meaningful.
A coexistence of pemphigus vulgaris and type II diabetes in geriatric patient: a case report
Authors: Suryawati Nyoman , Praharsini I Gusti Ayu Agung , Wardhana Made , Darmaputra I Gusti Nyoman
Published: November 2020

Background: Pemphigus Vulgaris (PV) is an autoimmune bullous disorder that usually affected the middle-aged and elderly. PV management in elderly patients is still a challenge for clinicians because of an increased risk of developing diabetes in the elderly. Corticosteroid is the first-line treatment for PV; however, careful consideration should be taken for diabetes patients due to the risk of disrupting glucose control leading to acute decompensation.Case: A seventy-year-old female with type II diabetes reported to Sanglah General Hospital with multiple painful blisters on the chest, back, and oral mucous. She has been treated with insulin since last year, but the treatment was non-compliant. Dermatological examination showed multiple flaccid bullae containing serous fluid with a positive Nikolsky sign, and multiple skin erosions. Histopathology finding is appropriate with PV. The Tzank smear examination revealed acantholytic cells. She was diagnosed with PV and typed II diabetes; therefore, we treated her with azathioprine, insulin and Lantus injection; sodium chloride 0.9% compress and fusidic acid cream 2% twice daily for topical treatment.Conclusion: Azathioprine is the treatment of choice because it works by blocking DNA replication without increasing blood glucose levels. The selection of appropriate medications can improve patient prognosis.
Differences of locomotor activities in the dementia rat model induced by oral d-galactose and intraperitoneal injection
Authors: Widyastuti Ketut , Laksmidewi Anak Agung Ayu Putri , Adnyana I Made Oka , Samatra Dewa Putu Gde Purwa
Published: November 2020

Background: The aging process can increase the incidence of neurodegenerative diseases such as dementia. Dementia is characterized by a gradual loss of cognitive performance for locomotor activity in exploring new environments. Research on dementia in mice was carried out by administering d-galactose to induce mitochondrial dysfunction, oxidative stress, inflammation and apoptosis of neurons.Objective: The purpose of this study was to determine differences in locomotor activity in rats induced by oral d-galactose and intraperitoneal injection.Methods: An experimental study with a posttest control group design. The subjects were male Wistar rats aged 12-14 weeks with weighing 200-300gram obtained from the Animal Laboratory of the Pharmacology Unit of the Faculty of Medicine, Udayana University. The study was conducted for 8 weeks, from June to August 2019. A total of 20 rats induced d-galactose dose of 100 mg/kg/day orally and intraperitoneal injection. The use of animals was carried out after obtaining ethical clearance from the ethical committee of the Faculty of Medicine, Udayana University. Y maze test is conducted for 5 minutes at the end of week 8.Results: There was a decrease in locomotor activity in both groups. The average locomotor activity in the oral group was 6.5+0.268, and the injection group was 5.5+0.341. Bivariate analysis with unpaired t-test showed significant differences in locomotor activity between groups given oral d-galactose compared to the intraperitoneal injection group with p=0.034 (<0.05).Conclusion: Alzheimer's dementia induced d-galactose mice to have a different locomotor activity after administration by oral or intraperitoneal injection of d-galactose. This study supports the results of previous studies that the administration of d-galactose can cause impaired locomotor activity.
Factors related to the use of internet in Bali by women as a source of information about pregnancy, childbirth, and baby care: a cross-sectional study
Authors: Ariyani Ni Wayan , Wirawan I Made Ady , Duarsa Dyah Pradnya Paramitha
Published: November 2020

Purpose: This study aims to identify the relationship between sociodemographic and obstetric factors with the use of the internet by women as a source of information about pregnancy, childbirth, and baby care.Method: This cross-sectional study involved 185 women who had babies aged 0-3 months. Data were collected in August and September 2018. Data were collected by interviews using questionnaires. Data analysis was conducted by chi-square and logistic regressionResults: The age factor (p = 0.255), education (p = 0.071), occupation (p = 0.100), income (p = 0.077) and parity (p = 0.380) were not related to the use of the internet. The factor of service provider is significantly related to internet usage (p = 0.031).Conclusion: The use of the internet by women in Bali to search information about pregnancy, childbirth, and baby care is not related to most sociodemographic and obstetric characteristics. The results of this study could be taken into consideration by health practitioners to create innovative programs in the field of maternal and child health services.
Acute angle closure glaucoma: management in acute attack setting
Authors: Wetarini Krisnhaliani , Dewi Ni Made Ratih Purnama , Mahayani Ni Made Widya
Published: November 2020

Introduction: Acute angle closure glaucoma is an emergency ophthalmic condition that occurs due to a sudden closure of the angle in the anterior chamber of the eye, causing an abrupt intraocular pressure (IOP) increase. The purpose of writing this case is to present clinical findings in acute glaucoma and the initial managements taken in reducing IOP.Case: A 45-year-old gentleman presented with 24-hour history of sudden severe left-sided headache associated with reduced vision on his left eye. Examination on the left eye revealed mixed conjunctival and ciliary injection, with visual acuity of 4/60 and raised intraocular pressure with the value of 40.2 on Schiotz tonometry. The anterior chamber was shallow, cornea was edematous, pupil was mid-dilated with diameter of 4 mm and unresponsive to light, iris crypt unclear, and hazed lens. The contralateral eye had a deep anterior chamber with normal pressure and a clear lens. He was treated initially by oral acetazolamide 250 mg two times a day, oral analgesic, a topical beta blocker 0,5% two times a day, and a topical steroid six times a day.Conclusion: A prompt and appropriate management in cases of acute glaucoma can prevent further complications and permanent blindness.
Hemisection of the first-molars mandibula: a case report
Authors: Widiadnyani Ni Kadek Eka
Published: November 2020

Background:Â Hemisection is an endodontic surgery performed by removing one or more roots and existing crown structures to increase retention of the remaining teeth and to correct defected dental roots that are not possible to maintain. This study aims to evaluate the treatment of hemisection in the lower left first molar in the mesial tooth root with the restoration of the splint crown end with tooth 35 as retention at Sanglah General Hospital, Bali, Indonesia.Â Case Description:Â Male patient aged 21 years, in tooth 36 there is a cavity with a temporary restoration accompanied by a periodontal abscess. Teeth are sensitive to percussion tests and palpation, mobility is normal. Radiographic features appear to be perforated in the furcation section, and furcation involvement. Diagnosis of teeth 36 pulp necrosis is accompanied by abscess periodontal. During the first visit periodontal abscess drainage was performed, followed by functional crown lengthening in the periodontia. After one week of observation, there were no complaints, continued treatment of the distal root canal until the root canal filling. The next visit was carried out hemisection surgery in the form of separation of root bifurcation and extraction of mesial roots to the existing crown structure. Two months after the surgical procedure was evaluated, there was a good increase in bone density and no complaints. Then, the tapered serrated post was accompanied by the manufacture of composite core and final restoration using PFM crown splint with tooth 35 as retention.Â Conclusion:Â Surgical treatment of hemisection is a reliable alternative solution and has a good prognosis because it can maintain dental and periodontal tissue as long as possible without tooth extraction.
Efficacy of revision urethroplasty in the treatment of recurrent urethral strictures at a tertiary hospital (Kenyatta National Hospitalâ€“KNH), in Nairobi Kenya: 2015-2018
Authors: Otele Willy H. , Miima Sammy , Owilla Francis , Monda Simeon
Published: November 2020

Background: Urethral strictures cause malfunction of the urethra. Urethroplasty is a cost-effective treatment option. Its success rate is greater than 90% where excision and primary anastomosis(EPA)is performed and 80-85% following substitution urethroplasty. Definitive treatment for recurrent urethral strictures after urethroplasty is not defined. Repeat urethroplasty is a viable option with unknown efficacy.Method: Retrospective analysis of patients who underwent revision urethroplasty for unsuccessful urethroplasty at KNH from 2015 to 2018 was performed. Patientsâ€™ age, demographic data, stricture length, location, aetiology, comorbidities and type of urethroplasty was evaluated from records with complete data. Male patients aged 13 to 80years were evaluated. Comparison of urethroplasty outcome between two patient cohorts was made: Fresh urethroplasty patients versus failed urethroplasty who underwent revision so as to determine efficacy of the later. Principal outcome measure was urethral patency, while Subsidiary outcome measures were associated complications. Outcomes were compared using statistical package SPSS version 23.0.Result: 235 patients who met inclusion criteria underwent urethroplasty, 71.5% (n=168) had a successful outcome, while28.5% (n=67) failed and were subjected to revision urethroplasty. Another 58% were successful upon revision but experienced significant morbidity. Majority of urethral strictures were bulbomembranous. Trauma was the leading cause of urethral strictures followed by idiopathic strictures. EPA was the commonest surgery while Tissue transfer featured prominently in revision urethroplasty. A significant correlation was evident between stricture length, prior surgery, and procedure choice and urethroplasty outcome.Conclusion: Revision urethroplasty is feasible after failed urethroplasty but less efficacious. Stricture length, number of prior surgeries and procedure choice affected outcome.EPA and Tissue Transfer techniques are essential surgical armamentarium in revision setting.
The effects of ethyl acetate fraction of Moringa oleifera leaves on kidney and liver function in sepsis rat model
Authors: Sumandjar Tatar , Purwanto Bambang , Riswanto Riswanto , Rahman Arif
Published: November 2020

Backgrounds: Life-threatening organ dysfunction such as sepsis often happens in developing and developed countries. Ethyl acetate fraction of Moringa oleifera leaf (MO-EA fraction) is claimed by several studies to be able to control inflammation and oxidative stress.Objective: This study aims explore the effect of MO-EA fraction in improving the liver and kidney function in sepsis rat model.Materials and Methods: This study is an experimental research using sepsis rat model. The research was conducted on a total of 66 white Wistar rats aged 3-4 months, weighing 200-300 grams, randomly allocated into nine treatment groups, negative, and normal control groups. The treatment and the negative control group received LPS induction to reproduce the inflammation stress during a sepsis. The treatment groups receive various daily dose of MO-EA fraction starting of 10, 20, and 40 mg/kgBW. The measured outcome were serum creatinine, ureum, serum glutamic oxaloacetic transaminase (SGOT), and serum glutamic pyruvic transaminase (SPGT).Results:Â  There are statistically significant differences of the level of ureum, creatinine, SGOT, and SPGT between various treatment group receiving various dose of MO-EA fraction and negative and normal control group within seven days after LPS induction. Î±=0.05. Conclusion: The serum level of ureum, creatinine, SGOT and SGPT in the sepsis rats administered with MO-EA were lower than the control group. The best MO-EA fraction is A2 which was 20 mg/kgBW/day given from 5 days before the LPS induction continuing to the seventh day after the LPS induction. MO-EA fraction supplementation may have a potential as a preventive therapy for endothelial stress in sepsis rat model.
Incidental radiographic finding of charm needle or â€œsusukâ€ in orthodontic panoramic and lateral cephalometric radiograph: a case report
Authors: Walianto Surwandi , Wiwekowati Wiwekowati , Rahina Yudha
Published: November 2020

Background: The most common radiographic examinations in orthodontic are panoramic and lateral cephalometry. In panoramic and lateral cephalometric images in adult patients, sometimes can be found a fine foreign object which sometimes confuses as it scattered the radiographic image, such as needles. The needles found in the patients are known as â€œsusukâ€ in Malay and Indonesian language or charm needles which believed to enhance beauty, charism, health, youth, luck, and to relieve pain. This case reports aim to elaborate the incidental radiographic finding of charm needle or â€œsusukâ€ in orthodontic panoramic and lateral cephalometric radiograph.Case Description:Â There was four adult woman conducted panoramic and cephalometric radiograph as a routine procedure before orthodontic treatment. The number of susuk inserted were varied, as it considered that the more needle increases the magical potency. In Case 1, the panoramic image depicts one â€œsusukâ€ in the middle of the root of 44 (FDI notation) tooth. Besides, the cephalometric radiographs also show a â€œsusukâ€ horizontally inserted at the root of the anterior lower teeth area. The panoramic image reveals one susuk around chin area below the apex of 42 teeth on Case 2 as well as on the soft tissue chin area in front of the apex of 41 teeth on cephalometric radiographs. In Case 3, two â€œsusukâ€ were found inserted bilaterally symmetric at the upper premolar area by the panoramic image. Then, five â€œsusukâ€ in the mandible and four â€œsusukâ€ at the upper area of the maxilla were found in Case 4 by the panoramic image.Â Conclusion:Â The susuk are often exposed as incidental findings in panoramic and lateral cephalometric radiographs that are taken before performing routine orthodontic treatments. Understanding the presence of susuk is essential to avoid misdiagnosis and mismanagement and help radiologists to prevent confusion while interpreting images.
Effect of Platelet-Rich Plasma (PRP) on testicular damage in streptozotocin-induced diabetic rats
Authors: Hermilasari Rista Dwi , Rizal Dicky Moch , Wirohadidjojo Yohanes Widodo
Published: November 2020

Background:Â Diabetes mellitus (DM) is a condition which could lead to induce testicular damage due to oxidative stress by hyperglycemic stress. Several therapies have been elucidated to reduce the testicular damage; one of them is Platelet-Rich Plasma (PRP). PRP has known growth factor properties which may serve potential effects in the tissue regeneration. This study aims to determine the role of PRP on testes in streptozotocin-induced diabetic rats by evaluating itsÂ impact on testosterone serum level.Methods:Â A randomized clinical trial with control group design has been conducted among 20 rats in this study. The sample of rats was divided into four groups such as control, DM (streptozotocin-induced), DM-InsÂ (treated with insulin daily), and DM-Ins-PRP (treated with insulin daily and PRP thrice in 2 weeks). Six weeks later, the testosterone level was measured by ELISA, and the right testis was collected for histopathology findings. Data were analyzed using SPSS version 25 for Windows.Â Results:Â The testes weight in the control group was 1.61Â±0.37 grams, followed by DM group (0.86Â±0.22 grams), DM-Ins group (1.15Â±0.25 grams), and DM-Ins-PRP group (1.09Â±0.36 grams). DM reduced testicular weight, seminiferous tubules diameter, the thickness of the epitheliumÂ and testosterone serum level significantly (p<0.05) compared with control. PRP administration increases the thickness of seminiferous epithelium (p<0.05) significantly. Besides, it also increased the testicular weight, tubules diameter, lumen diameter, and testosterone serum level, but not significant (p>0.05).Conclusion:Â The administration of PRP showed a significant role in repairing testicular damage among diabetic rats.