bluuebunny/crossref_metadata_2025 huggingface dataset:
Digital Gangrene and Antiphospholipid Syndrome in a Retinoblastoma Patient with Chromosome 13q Deletion: A Case Report
Authors: Wangtiraumnuay Nutsuchar , Surukrattanaskul Supawan , Wangkittikul Chonthida
Published: April 2023

A 19-month-old girl with Cornelia de Lange-like dysmorphic features presented with left eye leukocoria. She was diagnosed with 13q deletion retinoblastoma grade 4 with high-risk features and bone marrow involvement. She underwent enucleation, and the first course of intravenous chemotherapy was initiated. On day 10 after the first chemotherapy dose, she developed digital gangrene of her left hand. She was diagnosed with acute artery occlusion and limb ischemia. Thrombophilia work-up revealed antiphospholipid antibodies, and paraneoplastic syndrome is another possible cause of digital gangrene. The patient’s left thumb and index finger were amputated. After 1 month of hospitalization, she was discharged. Before the second course of chemotherapy, the patient died of systemic metastatic retinoblastoma with respiratory failure due to pneumonia. Our postulation of the mechanism for digital gangrene was the combination of chemotherapy, paraneoplastic syndrome, and antiphospholipid syndrome. Digital gangrene could be a poor prognostic indicator in patients with retinoblastoma.
Evaluation of Team-Based Care Implementation in Primary Health Care Services in Saudi Arabia
Authors: Al-Zahrani Arwa Nasser , Aldahmashi Amjad Sulaiman , Radwan Nashwa Mohamed , Mahmoud Nagla El Tigani El Fadil , Alfaifi Amal Hussain , Al-Abdulkareemf Khalid Ibrahim
Published: April 2023

Introduction: Saudi Ministry of Health (MOH) is starting to transfer the delivery of primary health care (PHC) services from solo practice to team-based care (TBC) model. It is an important to understand factors that affect the integration of this new model of care in the early stage of implementation process to ensure adequate incorporation of this new intervention into the routine work in PHC centers. Normalization process theory (NPT) is a method that helps evaluate the integration of new interventions. Therefore, this study aimed to explain the integration of TBC model in PHC services and investigate the barriers that may hinder the implementation of this model through using NPT. Methods: A cross-sectional study was conducted in PHC centers of Saudi MOH 7 months after the implementation of TBC model. A systematic random sample technique was used to select participants from all Saudi regions. A NPT questionnaire was sent online to the participants to collect data. Results: The study revealed that cognitive participation construct represented the highest score (4.06 ± 0.74) followed by coherence (3.78 ± 0.87) and reflexive monitoring (3.75 ± 0.79) constructs. Collective action construct represented the lowest integration score (3.48 ± 0.68). Gender, years of work experience, and duration of applying TBC model were not significant factors affecting the mean integration scores of the four constructs of NPT. Conclusion: The study recorded good integration scores of the included health staff to TBC model. However, the study demonstrated some barriers that may hinder the implementation progress of the model including inadequate staff training, insufficient resources, and lack of feedback reports. Other recorded barriers are the staff perception that TBC model affects the nature of their work and disrupts the working relationship. Sufficient resources, adequate staff training with close supervision, and providing them with feedback reports regularly are recommended to support and improve the implementation of the TBC model in PHC services.
Вплив кастрації на розвиток адреналінового ушкодження серця в щурів, які зазнали хронічного гіподинамічного стресу
Authors: Друзюк Р. Б. , Денефіль О. В.
Published: April 2023

Мета роботи: оцінити вплив кастрації на розвиток окиснювальних процесів та морфологічних змін у серці щурів, які зазнали хронічного стресу, при адреналіновому ушкодженні серця (АУС).

Матеріали і методи. Досліди виконано на 120 білих щурах-самцях лінії Вістар. Усі тварини були розділені на дві серії: 1 – стрес, 2 – кастрація і стрес. Для відтворення АУС щурам вводили одноразово внутрішньочеревно 0,18 % розчин адреналіну гідротартрату з розрахунку 0,5 мг/кг маси (фармацевтична фірма “Дарниця”, Україна). Оцінювали розвиток окиснювального стресу та морфологічні зміни у серці в контролі, через 1, 3, 7, 14 і 28 діб після введення адреналіну.

Результати досліджень та їх обговорення. Кастрація і стрес у тварин ІІ серії, порівняно з І серією щурів, які зазнали тільки стресу, спричинила зменшення продуктів пероксидного окиснення ліпідів, але значне збільшення окисно модифікованих протеїнів. Супероксиддисмутазна активність у ІІ серії зросла, а каталазна активність значно зменшилася. Адреналін призвів до найбільшого накопичення ТБК-aктивних продуктів: у тварин, які зазнали стресу – через 14 діб, а кастрації і стресу – через 1 добу. Ступінь накопичення окисно модифікованих протеїнів вираженіший у тварин, які зазнали стресу, але абсолютні значення значно більші у щурів, які були попередньо кастровані. У І серії тварин після ін’єкції адреналіну зросла супероксиддисмутазна, але зменшилася каталазна активність. У ІІ серії тварин активність антиоксидантів збільшилася, але залишилася значно меншою, порівняно з показниками І серії щурів. Морфологічні зміни вказували на значне ушкодження міокарда і судинної стінки обох серій тварин. Кастрація спричинює більші порушення окснювальних процесів у серці щурів, які зазнали хронічного гіподинамічного стресу, при розвитку адреналінового ушкодження міокарда.
Роль і проблематика посмертного донорства
Authors: Загрійчук М. С. , Марчук І. П. , Підопригора О. О. , Мигалега Т. С.
Published: April 2023

Мета роботи: визначити залежність кількості експлантацій органів у ефективних посмертних донорів від віку та результатів лабораторних досліджень та дослідити частку придатних до трансплантації органів у останніх.

Матеріали і методи. В дослідження включили 14 посмертних донорів, у яких було виконано експлантацію органів у період від травня 2021 р. до грудня 2021 р. у КНП КОКЛ, з них 56,3 % становили чоловіки та 43,7 % жінки. За віком пацієнти були розділені на 2 групи: 1-ша група – молодші 50 років, 2-га група – 50 років та старші.

Результати досліджень та їх обговорення. За результатами статистичної обробки даних можна стверджувати, що групи достовірно не відрізнялись за статтю, індексом маси тіла, тривалістю перебування у ВРІТ й такими лабораторними показниками, як середній рівень креатиніну, натрію, АЛТ та АСТ, водночас спостерігалася достовірна різниця за вмістом сечовини та безпосередньо за віком, р=0,03 та р=0,000034 відповідно. Достовірної статистичної різниці за кількістю експлантацій не було.

Сучасний розвиток трансплантології в нашій країні дозволив у боротьбі за життя пацієнтів значно покращити результати. Посмертне донорство рятує життя одночасно щонайменше 4 осіб. В Україні не прописані критерії маргінального донорства, розширені критерії для донації та відсутній уніфікований протокол кондиціонування потенційного донора. Вік посмертного донора не є критичним критерієм для донації органів. Незважаючи на лабораторні показники безпеки донора, частина органів не придатна для подальшої трансплантації, в даному дослідженні це 36 % сердець, 43 % печінок та 7 % нирок. Подальші дослідження на більшій групі пацієнтів необхідні для подальшого вивчення ефективності використання донорів та післятрансплантаційних віддалених результатів.
Пристрій для лікування багатокамерних порожнин у хірургії
Authors: Кошак Ю. Ф. , Макаров В. В. , Савенков Ю. Ф. , Привроцький В. М.
Published: April 2023

У статті розглянуто можливості лікування пацієнтів при гострій хірургічній патології органів грудної клітки та черевної порожнини із застосуванням пристрою та методик дренування у важкодоступних зонах багатокамерної гнійної порожнини.
Avaliação da intensidade do treinamento de basquete em cadeira de rodas por monitoramento da frequência cardíaca em pessoas com deficiência física
Authors: Santos Adeliana Cristina Siqueira , Rodrigues Rosilene Andrade Silva , Balogun Sikiru Olaitan , Zarour Felipe Amorim , Freitas Roberto Luis Marques de , Rodrigues Daniela Alana Andrade Souto , Andrade Benedito Robson Monteiro de , Cavalcante Ramirie Nunes , Napoleão Amanda Colichio Bini , Fett Waléria Christiane Rezende , Salomão Alberto Bicudo , Fernandes Cleonice Terezinha , Fett Carlos Alexandre , Zavala Arturo Alejandro , Oliveira Ruberlei Godinho de
Published: April 2023

Objetivo: Verificar a intensidade do basquete em cadeira de rodas (BCR) em pessoas com deficiência (PCD) durante 8 semanas de intervenção. Métodos: Estudo experimental longitudinal com 13 PCD foi avaliado o monitoramento da FC, freqüência cardíaca média (FCMéd) para cálculo da frequência cardíaca mínima (FCMin) e % frequência cardíaca de treinamento (% FCT) foram baseados na FCpico. Estes foram então analisados para possível correlação com o tipo, nível e tempo da lesão, bem como os valores antropométricos obtidos por bioimpedância. Resultados: Após análise estatística, nas variáveis independentes verificou-se que o percentual de gordura corporal (p <0,01), água intracelular e extracelular foram correlacionado positivamente (p <0,05) com % FCT. As variáveis dependentes, classificação funcional, nível e tipo de lesão e IMC não foram significativas (p> 0,05) quando correlacionadas com a FCpico. Conclusões: A maioria dos participantes obteve a % FCT acima de 60% da FCpico e indicando que a intervenção auxiliou na promoção da saúde cardiovascular, além dos benefícios mencionados dos níveis de hidratação e % gordura corporal de cada indivíduo. O presente estudo pode servir de base científica para o educador físico e afins, principalmente no que diz respeito ao uso do basquete em cadeira de rodas na reabilitação ou treino de aptidão física para PCD.
Effects of the vacation period on the health-related physical fitness of schoolchildren
Authors: Vieira Bruno Allan , Leonel Larissa dos Santos , Katcipis Luiz Felipe Guarise , Silveira Julia da , Dallegrave Eduardo José , Delevatti Rodrigo Sudatti
Published: April 2023

The aim of the study was to verify the effects of the summer vacation period on the health-related physical fitness (HRPF) of students in the 7th and 8th grades of elementary school. The study design is characterized as observational, considered short-term longitudinal. Physical evaluations were carried out before and after the summer school vacation period. The components of physical fitness analyzed were: Cardiorespiratory fitness - 6-minute running or walking test, body composition- measures of body mass index, waist circumference and waist-to-height ratio, muscle strength/endurance - abdominal endurance test (sit -up) and flexibility - test of sitting and reaching. As a statistical analysis, the paired t-test was used, adopting p≤0.05. A significant increase was observed in the body mass index, waist circumference, waist-to-height ratio and flexibility after the vacation period. However, there were no significant changes in cardiorespiratory fitness and muscle strength/endurance. Furthermore, analyzing boys and girls separately, no differences were found for waist-to-height ratio and only girls showed improvements in muscle strength/endurance. It was concluded that the vacation exposure factor improved the levels of flexibility and increased the variables of body composition, not generating significant changes in cardiorespiratory fitness, while muscle strength/endurance improved only in girls.
Padrão de movimento do forehand no tênis de mesa paraolímpico: comparação entre realidade virtual econdições de tarefa real
Authors: Guimarães Edna Azevedo , Carrara Paulo Daniel Sabino , Teruya Thiago Toshi , Neiva Jaqueline Freitas de Oliveira , Silva Talita Dias da , Monteiro Carlos Bandeira de Mello , Mochizuki Luis
Published: April 2023

O objetivo deste estudo foi comparar o padrão de movimento de forehand do tênis de mesa durante a realidade virtual e as condições de tarefa real. Dezenove tenistas de mesa paraolímpicos realizaram o forehand em ambientes reais e virtuais. Um acelerômetro tridimensional fixado na raquete de tênis de mesa e no controle remoto do Wii foi usado para registrar dados cinemáticos de forehand. Aceleração e arrancada foram as variáveis cinemáticas analisadas durante o forehand. A aceleração de forehand (H=3,9 p=0,04) e a arrancada (F1,36=25,1 p<0,001) no ambiente real foram significativamente maiores do que no ambiente virtual na direção transversal. Assim, a prática em ambiente virtual não forneceu estímulo suficiente para que os mesa-tenistas paralímpicos reproduzissem padrões de movimento de forehand como no ambiente real. A prática em ambiente virtual pode contribuir, mas não substituir a prática em ambiente real para atletas mesa-tenistas paralímpicos.
Níveis de atividade física de estudantes do curso de Educação Física de uma faculdade do interior da Bahia
Authors: Araújo Alan Michel dos Santos , Santos Erlandia Carvalho dos , Souza Júnior Marivaldo Moreira de , Ferreira Marcelle Esteves Reis , Cardoso Gustavo Marques Porto
Published: April 2023

O objetivo do estudo foi analisar os aspectos sociodemográficos e os níveis de atividade física de estudantes do curso de Bacharelado em Educação Física de uma faculdade privada do interior da Bahia, mais especificamente os ingressantes e concluintes, bem como os fatores que podem interferir no modo de vida ativo ou inativo destes futuros profissionais de Educação Física. Para tanto, aplicou-se o Internationaly Physical Activity Questionnaire - IPAQ, em sua versão curta e em português, a fim de avaliar as supostas variáveis que podem influenciar e/ou influenciam no nível de atividade física dos sujeitos pesquisados. Os dados coletados foram tabulados e classificados de acordo com a orientação do próprio IPAQ: Sedentário, Insuficientemente ativo A, Insuficientemente ativo B, Ativo e Muito ativo, a depender da duração, frequência e intensidade da prática de atividade física semanal, sendo classificadas como pessoas “ativas” aquelas que alcançaram a soma de 300 minutos ou mais nesse ínterim. Os dados demonstraram que a grande maioria dos estudantes pesquisados eram, em sua maioria, do sexo masculino, de baixa renda, que moravam com a família, em casa ou apartamento, egressos de escola pública, não possuíam financiamento estudantil e se deslocavam por meio de veículo automotor (moto, carro, ônibus, van). Além disso, eram fisicamente ativos e não apresentavam comportamento sedentário, havendo um equilíbrio entre o nível de atividade física de ingressantes e concluintes.
Sono do jovem atleta de alto rendimento: análise da comparação de uma medida objetiva e uma subjetiva para determinação do padrão de sono
Authors: Guglielmi Vitor Hugo , Lopes Marcos Winicius Rodrigues , Santos Eduardo Henrique Rosa , Brilhante Junior Wanderley , Grava Flavio , Pedrazzoli Mario
Published: April 2023

Atletas profissionais tendem a fazer a sua formação durante a adolescência, nesta fase da vida, o sono tem suas particularidades e fatores como a maturação biológica e os horários de compromissos sociais estão associados com a qualidade de sono do adolescente. O sono de qualidade está relacionado com alto desempenho e resistência a injúrias na prática do esporte. Desta forma é pertinente tentar entender o sono do atleta adolescente. O objetivo do presente estudo foi avaliar o padrão de sono e comparar medidas objetivas e subjetivas do sono em jovens atletas de futebol. Participaram do estudo 62 atletas de alto rendimento de categorias de base, SUB17 e SUB20, de dois clubes de futebol do estado de São Paulo. Para a coleta dos dados de sono foram utilizados o Questionário de Cronotipo de Munique (MCTQ) e a actigrafia (ACT). Foram encontradas discrepâncias entre as medidas objetivas e subjetivas de sono, de forma geral, os atletas subestimam seus horários e a duração de seu sono e apresentam bastante jetlag social, que é um índice de ruptura de ritmos biológicos. A observação dos nossos dados indica que os jovens atletas não têm uma qualidade do sono adequada, estão sujeitos a disrupção da ritmicidade circadiana e apresentam uma auto-observação pobre destes aspectos do funcionamento dos seus corpos. Desta forma podemos concluir que tomar medidas para a otimização do treinamento que incluam aspectos educacionais do sono tem o potencial de melhorar o desempenho e evitar lesões ao longo da carreira de jovens atletas. Uma medida clara que emerge do presente estudo é que o atraso na hora do início do treino permitiria que os atletas aumentassem a duração do sono.
Urate-Lowering Therapy Inhibits Thoracic Aortic Aneurysm and Dissection Formation in Mice
Authors: Yang Liu , Wu Hao , Luo Congcong , Zhao Yang , Dai Rongbo , Li Zhiqing , Zhang Xu , Gong Ze , Cai Zeyu , Shen Yicong , Yu Fang , Li Wei , Zhao Hongmei , Zhang Tao , Zhu Junming , Fu Yi , Wang Jing , Kong Wei
Published: April 2023

Background:

Thoracic aortic aneurysm and dissection (TAAD) is a highly lethal vascular disease without effective drug therapy. Whether elevated serum concentrations of uric acid are involved in TAAD development remains unclear.

Methods:

Serum uric acid levels were detected in different TAAD mouse models and patients. The urate-lowering drug allopurinol was administered in the drinking water of TAAD mice. Adenine diet–induced mice were established to investigate the role of hyperuricemia in TAAD formation and RNA-sequencing of thoracic aortas from these mice was performed.

Results:

We found serum uric acid levels were elevated in various mouse TAAD models, including mice fed a β-aminopropionitrile diet, Marfan mice with
fibrillin-1
haploinsufficiency (
Fbn1

C1041G/+

), and
ApoE

−/−

mice infused with Ang II (angiotensin II), as well as in patients with TAAD. Administration of urate-lowering drug allopurinol in the drinking water significantly alleviated TAAD formation in β-aminopropionitrile–treated mice,
Fbn1

C1041G/+

mice, and Ang II–infused
ApoE

−/−

mice. Moreover, an adenine diet was used to induce hyperuricemia in mice. Intriguingly, a 4-week adenine diet feeding directly induced TAAD formation characterized by increased maximal thoracic aortic diameters and severe elastin degradation, which were ameliorated by allopurinol. Unbiased RNA-sequencing in mouse thoracic aortas suggested that FcγR (Fc gamma receptor) was upregulated upon adenine diet, but reciprocally repressed by allopurinol. Mechanistically, hyperuricemia activated FcγR-mediated ERK1/2 (extracellular signal-regulated kinase 1/2) phosphorylation to induce macrophage inflammation and TAAD development, which was abrogated by allopurinol or FcγR deficiency.

Conclusions:

This study uncovered an important and previously unrecognized role of hyperuricemia in mediating the pathogenesis of TAAD, and uric acid–lowering drug may represent a promising therapeutic approach for TAAD.
Bone Morphogenetic Protein 10—A Novel Biomarker to Predict Adverse Outcomes in Patients With Atrial Fibrillation
Authors: Hennings Elisa , Blum Steffen , Aeschbacher Stefanie , Coslovsky Michael , Knecht Sven , Eken Ceylan , Lischer Mirko , Paladini Rebecca E. , Krisai Philipp , Reichlin Tobias , Rodondi Nicolas , Beer Jürg H. , Ammann Peter , Conte Giulio , De Perna Maria Luisa , Kobza Richard , Blum Manuel R. , Bossard Matthias , Kastner Peter , Ziegler André , Müller Christian , Bonati Leo H. , Pfister Otmar , Zuern Christine S. , Conen David , Kühne Michael , Osswald Stefan ,   the Swiss‐AF Investigators
Published: April 2023

Background

Patients with atrial fibrillation (AF) face an increased risk of death and major adverse cardiovascular events (MACE). We aimed to assess the predictive value of the novel atrial‐specific biomarker BMP10 (bone morphogenetic protein 10) for death and MACE in patients with AF in comparison with NT‐proBNP (N‐terminal prohormone of B‐type natriuretic peptide).

Methods and Results

BMP10 and NT‐proBNP were measured in patients with AF enrolled in Swiss‐AF (Swiss Atrial Fibrillation Study), a prospective multicenter cohort study. A total of 2219 patients were included (median follow‐up 4.3 years [interquartile range 3.9, 5.1], mean age 73±9 years, 73% male). In multivariable Cox proportional hazard models, the adjusted hazard ratio (aHR) associated with 1 ng/mL increase of BMP10 was 1.60 (95% CI, 1.37–1.87) for all‐cause death, and 1.54 (95% CI, 1.35–1.76) for MACE. For all‐cause death, the concordance index was 0.783 (95% CI, 0.763–0.809) for BMP10, 0.784 (95% CI, 0.765–0.810) for NT‐proBNP, and 0.789 (95% CI, 0.771–0.815) for both biomarkers combined. For MACE, the concordance index was 0.732 (95% CI, 0.715–0.754) for BMP10, 0.747 (95% CI, 0.731–0.768) for NT‐proBNP, and 0.750 (95% CI, 0.734–0.771) for both biomarkers combined. When grouping patients according to NT‐proBNP categories (<300, 300–900, >900 ng/L), higher aHRs were observed in patients with high BMP10 in the categories of low NT‐proBNP (all‐cause death aHR, 2.28 [95% CI, 1.15–4.52], MACE aHR, 1.88 [95% CI, 1.07–3.28]) and high NT‐proBNP (all‐cause death aHR, 1.61 [95% CI, 1.14–2.26], MACE aHR, 1.38 [95% CI, 1.07–1.80]).

Conclusions

BMP10 strongly predicted all‐cause death and MACE in patients with AF. BMP10 provided additional prognostic information in low‐ and high‐risk patients according to NT‐proBNP stratification.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT02105844.
Knowledge gaps and conservation priorities for west African chelonians
Authors: McGovern Pearson , Luiselli Luca
Published: April 2023

Defining priorities is important both in research and in conservation, especially when knowledge gaps are hindering successful management. In this review, we quantify the knowledge gaps for all non-marine West African chelonians based on 21 criteria. Additionally, we combine these knowledge gaps with each species’ maximum size, range size, presence in nationally protected areas, and IUCN Red List or TFTSG provisional status to introduce a ranking of species conservation priority in the region. Our analyses revealed a divergence between which species are lacking research studies and which would benefit most from conservation actions, though Cyclanorbis elegans is the species that is both the least-known and most-in-need of conservation. Broadly, Pelomedusidae are in the greatest need of research, yet they are also collectively the least threatened. Conversely, Trionychidae and Testudinidae have received greater research attention in most cases, however, these two families represent the greatest conservation priorities amongst West African chelonians. Our analyses also enabled us to evaluate which criteria representing aspects of chelonian biology have been most overlooked by the scientific community. Priorities for future research include reproductive and long-term population studies, each of which are critical for informing conservation actions and evaluating the results of those actions.
The Building Accounts of the Fourth Century BC Temple of Apollo at Delphi
Authors: Hansen Erik
Published: April 2023

In this article, Hansen analyzes and discusses the construction of the fourth-century BC. Temple of Apollo at Delphi, taking into consideration the practical aspects of this difficult construction process. He includes the unique epigraphic building accounts that have been made accessible to non-philologists with Jean Bousque’s edition and French translation of the fragments published in 1989. Thereby Hansen offers a masterful revised calendar of the whole building process of the third largest temple on the Greek mainland.
The Front of a Temple and Swimming Girls by the Andokides Painter (around 520 BC)
Authors: Corso Antonio
Published: April 2023

This article focuses on an amphora by the Andokides Painter which dates in the late sixth-century BC, representing naked girls who swim in a basin of water with fish in front of a building endowed with a column and an architrave. Several considerations lead to the conclusion that these girls are young Athenian females in the sanctuary of Artemis Brauronia, in front of the temple built by Peisistratos. Thus, we may have the first representation of this sanctuary in our visual evidence.
Rings, Pits, Bone and Ash: Greek Altars in Context
Authors: Ekroth Gunnel
Published: April 2023

Greek altars have received ample attention in scholarship as to their appearance, construction, and location within a sanctuary, as well as their importance as the central feature for the rituals allowing communication with the gods. The immediate surroundings of altars have not been considered to the same degree. This paper explores the context of Greek altars and some of the features located here, for example, rings for fastening animals, stone-lined pits, and remains of previous sacrifices. Of particular interest is the use of the top of the altar for ritual purposes in relation to the space surrounding the altar. A study of the wider contexts of altars, as to their use and the material remains found here, may provide a better understanding of the complex ritual reality of the ancient Greeks.
Comparing the Two “Cold Wars” Through Gramsci, Althusser and Mao
Authors: Kadri Jude
Published: April 2023

There are three overlapping objectives in the article. The first objective is to present three different Marxist perspectives, while focusing on the interpretation of the base/superstructure dialectic which is the key to the understanding of Marxian political economy. The second objective is to make sense of the first and second “Cold Wars” based on the different interpretations of the base/superstructure dialectic. The last objective is to reassert the materialist essence of the base/superstructure dialectic by evoking Marx and his concepts of “Labor” and “Capital”. The three different perspectives are analyzed based on this reassertion. Through these three objectives, two deductions were made: the first deduction is that scientific Marxism requires the acknowledgement of the overdetermination of the economic base (its dominance in the last instance) in the analysis of abstractions, empirical and historical data. The “totality of the relations of production” within the economic base appears abstract in nature, but it represents the ontological category of “Labor” that defines human history since its beginning. It has a transhistorical essence. Human beings work together to produce their basic needs, according to historically specific (abstract) relations of production. The superstructure determines the specificity of the relations of production; it defines the “historical” side of the relations of production in the economic base. In the era of capitalism, “Capital” (the private appropriation of social wealth) is the dominant relation that comes to dictate the “totality of the relations of the production” within the economic base, through the superstructure. Total capital is then the real “subject” of history, and all abstractions gain purpose and practicality based on the class struggle between Labor and Capital. The second deduction relates to real history explained on the basis of the first deduction. Looking at the historical development of the class struggle against monopoly-finance capital (the centralized and concentrated capital) in the 20th century, the First Cold War never truly ended even though the global socialist ideology became weak and the ideological struggle against the imperialist superstructure watered down.
Cross-Movement Strike Actions: Works Council and Communist Groups at the Bremer Vulkan Shipyard in the 1970s
Authors: Wolf Johanna
Published: April 2023

Beginning in the early 1970s, various communist groups decided to become active at the Bremer Vulkan shipyard. The article shows that they did not immediately go for confrontation to older trade union structures but were willing to change the movement from within. With the support of a wildcat strike at the shipyard in 1973, the New Left raised the question of alternatives. As a result, the Social Democratic works council chairman resigned because of a lack of support from his colleagues, and in 1974 some communists were elected to the works council. I argue that there was no division into old and new but rather a diverse field of actors: a disparate group of workers with different occupational status, and political approaches; works councils and shop stewards with close ties to Bremen’s Social Democracy; and various communist groups that pursued very different policies and goals, sometimes joined forces, but basically fought each other—especially in conflicts—rather than taking joint action.
Inocybe hamadryadis (Inocybaceae, Agaricales), a new smooth-spored species from Europe and West Asia
Authors: RODRÍGUEZ-CAMPO FRANCISCO J. , BANDINI DITTE , OLARIAGA IBAI
Published: April 2023

Inocybe hamadryadis sp. nov. is described and a detailed description, colour photographs, microdrawings and photographs of the microscopic features are provided. The type was found under Quercus ilex and Cistus ladanifer in Mediterranean habitat in Spain, but its distribution is throughout Europe and the West Asia. Inocybe hamadryadis is characterized by a finely textured, pale to dark brown or chestnut brown pileus with a faintly greyish velipellis, smooth basidiospores, hymenial cystidia with sinuous walls and caulocystidia only near the extreme apex of the stipe. Our analyses of the ITS and LSU regions, including coded indel information, indicate that I. hamadryadis is closely related to I. tenuicystidiata, from which it differs in several morphological features, such as the smaller basidiospores on average and the shorter caulocystidia.
Gomphocymbellopsis guijiangensis sp. nov. (Cymbellaceae; Bacillariophyta), a new species from Guangxi Province with comments on associated specimens from Hubei Province, China
Authors: GUO JI-SHU , NI HONG-PING , LI YU-JIE , KOCIOLEK JOHN PATRICK , LI YAN-LING
Published: April 2023

Gomphocymbellopsis guijiangensis sp. nov. and G. sp. were collected from the Guijiang River and from fossil deposits of the Jianghan Plain, respectively. The morphology of this new species is described by both light and scanning electron microscopy and compared with G. ancyli, the only other species of the genus Gomphocymbellopsis. G. guijiangensis sp. nov. is characterized by valves that are asymmetrical to the transapical axis and weakly asymmetrical to the apical axis, by the presence of pore fields at the apices, by three differently shaped stigmata, by externally and dorsally deflected distal raphe ends, and by often ventrally deflected proximal raphe ends. Therefore, we describe here G. guijiangensis sp. nov. as species new for science. Concise notes on the associated diatom flora and its ecological preferences are provided.
A new species of Boletinellus (Boletinellaceae, Boletales) from India
Authors: NANU SALNA , ARUN KUMAR T. K.
Published: April 2023

A new species of Boletinellus, namely B. viridianus, is described from India based on morphological and molecular data. B. viridianus is characterized by basidiomata with a deeply decurrent poroid-lamellate hymenophore turning blue-green on bruising, an eccentric to lateral stipe covered with the hymenophoral structure extending lengthwise, oblong to ellipsoid, thin- to thick-walled, inamyloid basidiospores, two- to four-spored basidia, a pileipellis that is primarily a cutis interrupted by trichodermal clusters, and the presence of clamp connections. DNA sequences of internal transcribed spacer (ITS) and 28S rDNA (28S) gene loci were used for phylogenetic analysis. Detailed description, color photo plates, a species comparison table, and a taxonomic key to Boletinellus species known worldwide are provided.
A new species of Cyrtodactylus (Squamata: Gekkonidae) from Phu Yen Province, Vietnam
Authors: DO DANG TRONG , DO QUYEN HANH , LE MINH DUC , NGO HANH THI , ZIEGLER THOMAS , NGUYEN TRUONG QUANG , PHAM CUONG THE
Published: April 2023

We describe a new species of the genus Cyrtodactylus based on six adult specimens from Lac Dao forests, Phu Yen Province, southern Vietnam. Cyrtodactylus tayhoaensis sp. nov. is distinguished from the remaining Indochinese bent-toed geckos by a combination of the following characters: medium size (SVL up to 94.2 mm); nasal scales 5–6; internasal single or double; ciliaria 29–34; dorsal tubercles in 20–22 irregular transverse rows; ventral scale in 37–41 longitudinal rows at midbody; ventrolateral folds present without interspersed tubercles; precloacal pores absent in females, precloacal pores 4 or 5 in males; 10 or 11 enlarged femoral scales on each thigh; femoral pores 3–7 in males, absent in females; postcloacal tubercles 3 or 4; lamellae under toe IV 22–24; dorsal pattern consisting of unclear transverse bands formed by irregularly shaped dark-brown blotches, a discontinuous neckband with V-shape or triangle shape in the middle, dorsal head surface with dark-brown blotches; subcaudal scales transversely enlarged. In the phylogenetic analyses, the new species is recovered as a sister taxon to C. kingsadai with approximately 4% genetic divergence between the two species based on a fragment of the COI gene. This is the second species of Cyrtodactylus known from Phu Yen Province located in southern Vietnam.
Overactive bladder and multiple sclerosis in the University Hospital of Oujda
Authors: El Moudane Anouar , Chhita Kaoutar , Jdaini Ahmed , Motaouakil Abdessamad , Mebrouk Yassine , Barki Ali
Published: April 2023

Background

Multiple sclerosis (MS) is the most frequent autoimmune neurological disease in the young population. Vesico-sphincter disorders are frequent in the course of the disease; it has been reported that 90% of MS patients will develop a lower urinary tract disorder within 18 years of the diagnosis.

Methods

The aim of this study is to identify the frequency, severity, diagnosis, and treatment of overactive bladder (OAB) in MS patients at the Mohammed VI hospital university in Oujda-Morocco. It is a cross-sectional study. The population was collected in neurology department of Mohammed VI hospital university in Oujda-Morocco. The population cohort consisted of patients diagnosed with multiple sclerosis, which were invited to the urology department where they underwent urinary screening and completed a form of questions regarding the frequency and severity of OAB and its influence on quality of life.

Result

In our study, the mean age of the patients was 43 years, and our sample was composed of 48% males and 52% females, and the most frequent lower urinary tract symptom was urgency (57%), followed by urinary frequency (29%) and urge incontinence (14%). The recurrent-remittent form was the most frequent (62%), followed by the primary progressive form (24%) and the secondary progressive recurrent form (14%). Among the patients, 33% presented a mild symptomatology, 48% moderate, and 19% severe. In this study, it was found that the intensity of urinary symptoms and the MS disability score were positively correlated with quality of life and disease duration.

Conclusion

The urgency was the major symptom of the lower urinary tract, and the MS disability score and the severity of OAB were associated with the quality of life of the patients. The urological evaluation of patients with multiple sclerosis should be performed routinely to identify OAB and to treat this condition appropriately.
POInTbrowse: orthology prediction and synteny exploration for paleopolyploid genomes
Authors: Siddiqui Mustafa , Conant Gavin C.
Published: April 2023

We describe POInTbrowse, a web portal that gives access to the orthology inferences made for polyploid genomes with POInT, the Polyploidy Orthology Inference Tool. Ancient, or paleo-, polyploidy events are widely distributed across the eukaryotic phylogeny, and the combination of duplicated and lost duplicated genes that these polyploidies produce can confound the identification of orthologous genes between genomes. POInT uses conserved synteny and phylogenetic models to infer orthologous genes between genomes with a shared polyploidy. It also gives confidence estimates for those orthology inferences. POInTbrowsegives both graphical and query-based access to these inferences from 12 different polyploidy events, allowing users to visualize genomic regions produced by polyploidies and perform batch queries for each polyploidy event, downloading genes trees and coding sequences for orthologous genes meeting user-specified criteria. POInTbrowseand the associated data are online athttps://wgd.statgen.ncsu.edu.
Timing of intubation and ICU mortality in COVID-19 patients: a retrospective analysis of 4198 critically ill patients during the first and second waves
Authors: Manrique Sara , Claverias Laura , Magret Mónica , Masclans Joan Ramón , Bodi María , Trefler Sandra , Canadell Laura , Díaz Emili , Sole-Violan Jordi , Bisbal-Andrés Elena , Natera Ruth González , Moreno Antonio Albaya , Vallverdu Montserrat , Ballesteros Juan Carlos , Socias Lorenzo , Vidal Federico Gordo , Sancho Susana , Martin-Loeches Ignacio , Rodriguez Alejandro
Published: April 2023

Background

The optimal time to intubate patients with SARS-CoV-2 pneumonia has not been adequately determined. While the use of non-invasive respiratory support before invasive mechanical ventilation might cause patient-self-induced lung injury and worsen the prognosis, non-invasive ventilation (NIV) is frequently used to avoid intubation of patients with acute respiratory failure (ARF). We hypothesized that delayed intubation is associated with a high risk of mortality in COVID-19 patients.

Methods

This is a secondary analysis of prospectively collected data from adult patients with ARF due to COVID-19 admitted to 73 intensive care units (ICUs) between February 2020 and March 2021.

Intubation was classified according to the timing of intubation. To assess the relationship between early versus late intubation and mortality, we excluded patients with ICU length of stay (LOS) < 7 days to avoid the immortal time bias and we did a propensity score and a cox regression analysis.

Results

We included 4,198 patients [median age, 63 (54‒71) years; 71% male; median SOFA (Sequential Organ Failure Assessment) score, 4 (3‒7); median APACHE (Acute Physiology and Chronic Health Evaluation) score, 13 (10‒18)], and median PaO2/FiO2 (arterial oxygen pressure/ inspired oxygen fraction), 131 (100‒190)]; intubation was considered very early in 2024 (48%) patients, early in 928 (22%), and late in 441 (10%). ICU mortality was 30% and median ICU stay was 14 (7‒28) days. Mortality was higher in the “late group” than in the “early group” (37 vs. 32%, p < 0.05). The implementation of an early intubation approach was found to be an independent protective risk factor for mortality (HR 0.6; 95%CI 0.5‒0.7).

Conclusions

Early intubation within the first 24 h of ICU admission in patients with COVID-19 pneumonia was found to be an independent protective risk factor of mortality.

Trial registration

The study was registered at Clinical-Trials.gov (NCT04948242) (01/07/2021).
Evaluating an app for digital medical history taking in urgent care practices: study protocol of the cluster-randomized interventional trial ‘DASI’
Authors: Noack Eva Maria , Zajontz Dagmar , Friede Tim , Antweiler Kai , Hummers Eva , Schmidt Tobias , Roddewig Lea , Schröder Dominik , Müller Frank
Published: April 2023

Background

In out-of-hours urgent care practices in Germany, physicians of different specialties care for a large number of patients, most of all unknown to them, resulting in a high workload and challenging diagnostic decision-making. As there is no common patient file, physicians have no information about patients’ previous conditions or received treatments. In this setting, a digital tool for medical history taking could improve the quality of medical care. This study aims to implement and evaluate a software application (app) that takes a structured symptom-oriented medical history from patients in urgent care settings.

Methods

We conduct a time-cluster-randomized trial in two out-of-hours urgent care practices in Germany for 12 consecutive months. Each week during the study defines a cluster. We will compare participants with (intervention group) and without app use (control group) prior to consultation and provision of the self-reported information for the physician. We expect the app to improve diagnostic accuracy (primary outcome), reduce physicians’ perceived diagnostic uncertainty, and increase patients’ satisfaction and the satisfaction with communication of both physician and patient (secondary outcomes).

Discussion

While similar tools have only been subject to small-scale pilot studies surveying feasibility and usability, the present study uses a rigorous study design to measure outcomes that are directly associated with the quality of delivered care.

Trial registration

The study was registered at the German Clinical Trials Register (No. DRKS00026659 registered Nov 03 2021. World Health Organization Trial Registration Data Set, https://trialsearch.who.int/Trial2.aspx? TrialID = DRKS00026659.
Peripheral blood T-lymphocyte subsets are potential biomarkers of disease severity and clinical outcomes in patients with ulcerative colitis: a retrospective study
Authors: Geng Bailu , Ding Xueli , Li Xiaoyu , Liu Hua , Zhao Wenjun , Gong Haihong , Tian Zibin , Guo Jing
Published: April 2023

Background

Ulcerative colitis (UC) is considered an immune-mediated disease. The disorder of T-lymphocyte subsets plays an important role in the pathogenesis of UC. The aim of this study was to evaluate the significance of peripheral blood T-lymphocyte subsets in assessing disease severity and predicting clinical outcomes in UC patients.

Methods

The retrospective case-control study was performed in 116 UC patients with active disease and 90 healthy controls (HC). The UC patients included were followed up for 180 days. Analyses of t-test, Spearman’s correlation coefficient, multivariable Cox regression analysis, receiver operating characteristic (ROC) curves and cumulative survival analysis were done.

Results

The UC patients had lower proportions of CD4+T cells (42.85%±9.77% vs 45.71%±7.94%, P=0.021) and higher proportion of CD8+T cells (27.88%±8.86% vs 25.00%±6.47%, P=0.008) than HC. The severely active UC patients had higher proportion of CD3+HLA-DR+ T cells (8.83%±6.55% vs 2.80%±1.55%, P<0.001; 8.83%±6.55% vs 4.06%±5.01%, P<0.001) and CD8+T cells (31.35%±8.49% vs 26.98%±7.98%, P=0.029; 31.35%±8.49% vs 25.46%±9.15%, P=0.003) than mild and moderate group, whereas lower proportion of CD4+CD25+T cells (2.86%±1.35% vs 3.46%±1.07%, P=0.034) than mild group and CD4+T cells (40.40%±9.36% vs 44.73%±10.39%, P=0.049) than moderate group. The area under the curve (AUC) of CD3+HLA-DR+ T cells for assessing severely active UC was 0.885, with the cut-off value of 5.33%. The sensitivity was 76.32% and specificity was 89.74%. The combination of CD3+HLA-DR+ T cells and CRP had stronger assessment value with AUC of 0.929. The AUC of CD8+T cells, CD4+/CD8+ ratio and CD4+CD25+T cells for assessing disease severity was 0.677, 0.669 and 0.631 respectively. Within the 180 days follow-up, 24 patients (20.69%) had UC-related readmission or surgery, with higher proportion of CD3+HLA-DR+ T cells (10.66%±9.52% vs 3.88%±2.56%, P=0.003) and CD8+T cells (31.19%±10.59% vs 27.01%±8.20%, P=0.039) than those without readmission and surgery. The proportion of CD3+HLA-DR+ T cells was the independent predictor of UC-related readmission or surgery (HR=1.109, P=0.002). The AUC of CD3+HLA-DR+ T cells for predicting readmission or surgery was 0.796 with the cut-off value of 5.38%. UC patients with CD3+HLA-DR+T cells proportion>5.38% had a shorter time to readmission or surgery (log-rank test, P<0.001).

Conclusions

The combination of CD3+HLA-DR+T cells and CRP may be potential biomarker of disease severity in UC patients. The high proportion of CD3+HLA-DR+T cells may be associated with an increased risk of readmission or surgery in UC patients.
Sleep movements and respiratory coupling as a biobehavioral metric for early Alzheimer’s disease in independently dwelling adults
Authors: Khosroazad Somayeh , Gilbert Christopher F. , Aronis Jessica B. , Daigle Katrina M. , Esfahani Masoumeh , Almaghasilah Ahmed , Ahmed Fayeza S. , Elias Merrill F. , Meuser Thomas M. , Kaye Leonard W. , Singer Clifford M. , Abedi Ali , Hayes Marie J.
Published: April 2023

Introduction

Sleep disorder is often the first symptom of age-related cognitive decline associated with Alzheimer’s disease (AD) observed in primary care. The relationship between sleep and early AD was examined using a patented sleep mattress designed to record respiration and high frequency movement arousals. A machine learning algorithm was developed to classify sleep features associated with early AD.

Method

Community-dwelling older adults (N = 95; 62–90 years) were recruited in a 3-h catchment area. Study participants were tested on the mattress device in the home bed for 2 days, wore a wrist actigraph for 7 days, and provided sleep diary and sleep disorder self-reports during the 1-week study period. Neurocognitive testing was completed in the home within 30-days of the sleep study. Participant performance on executive and memory tasks, health history and demographics were reviewed by a geriatric clinical team yielding Normal Cognition (n = 45) and amnestic MCI-Consensus (n = 33) groups. A diagnosed MCI group (n = 17) was recruited from a hospital memory clinic following diagnostic series of neuroimaging biomarker assessment and cognitive criteria for AD.

Results

In cohort analyses, sleep fragmentation and wake after sleep onset duration predicted poorer executive function, particularly memory performance. Group analyses showed increased sleep fragmentation and total sleep time in the diagnosed MCI group compared to the Normal Cognition group. Machine learning algorithm showed that the time latency between movement arousals and coupled respiratory upregulation could be used as a classifier of diagnosed MCI vs. Normal Cognition cases. ROC diagnostics identified MCI with 87% sensitivity; 89% specificity; and 88% positive predictive value.

Discussion

AD sleep phenotype was detected with a novel sleep biometric, time latency, associated with the tight gap between sleep movements and respiratory coupling, which is proposed as a corollary of sleep quality/loss that affects the autonomic regulation of respiration during sleep. Diagnosed MCI was associated with sleep fragmentation and arousal intrusion.