bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of Gliclazide Modified Release or Glimepiride as Add-on Therapy to Metformin on Glycemic and Oxidative Stress Parameters in Type 2 Diabetic Patients
Authors: Fadhel A. Shehab  , Ali L. Jasim2  , Adel Gh. Mohammed
Published: June 2024

Background: Type 2 diabetes mellitus is a condition characterized by an elevation of oxidative stress, which has been implicated in diabetic progression and its vascular complications.
Aim: Assessing the impact of gliclazide modified release (MR) versus glimepiride on oxidative stress markers, glycemic indices, lipid profile, and estimated glomerular filtration rate in uncontrolled type 2 diabetic patients on metformin monotherapy.
Methods: This was an observational comparative study conducted in Thi-Qar specialized diabetic, endocrine, and metabolism center. Sixty-six patients were randomized into two groups based on the addition of the sulfonylureas (SUs). Group 1 (33 patients) was on gliclazide MR, whereas Group 2 (33 patients) was on glimepiride. The measured oxidative stress markers were reduced glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA), and protein carbonyl (PC) evaluated before and after 16 weeks of SUs addition.  
Results: There were significant drops in SOD (P < 0.001), MDA (P < 0.001), and PC (P = 0.001) and a significant increase in GSH (p = 0.029) levels after gliclazide MR add-on therapy. There were significant drops in SOD (P = 0.026) and MDA (P < 0.001) levels with non-significant changes in both GSH (P = 0.214) and PC (P = 0.538) after glimepiride add-on therapy. There was a significant difference in improvement of PC level (P = 0.048) in the gliclazide group compared to the glimepiride group, with a non-significant numerically higher improvement of GSH, SOD, and MDA in gliclazide MR than glimepiride. At the end of the study, there were no significant differences in glycemic control, lipid profile, or eGFR improvement between the two groups.
Conclusion: Glycemic control plays a pivotal role in decreasing oxidative stress. The control of diabetes with the gliclazide-MR-metformin combination reduced oxidative stress more than the glimepiride-metformin combination, indicating its antioxidant property.
Keywords: Oxidative Stress, T2DM, Gliclazide MR, Glimepiride, Metformin.
Synthesis, Molecular Docking Study, Anti-Oxidant and Cytotoxicity Evaluation of New Spiro Six Membered Ring Derivatives of 5-nitro isatin
Authors: Hala Ayad Mohamed Rasheed  , Suaad M. H. Al-Majidi
Published: June 2024

Spiro-5-nitro isatino six memberd ring (quinazoline-4-one, thiazine-4-one and oxazine-4-one) respectively were produced by a cycloaddition of 5-nitro isatin Schiff bases [1–5] with anthranilic acid, o-mercapto benzoic acid and salicylic acid. 1HNMR and 13CNMR nuclear magnetic resonance spectroscopies, as well as Fourier-transform infrared spectroscopy, were used to identify the structures of the obtained compounds. These spiro-5-nitro isatin are of interest to us due to their potential antioxidant and anticancer properties. The MTT assay ((3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide)) was used to examine in vitro bioactivity testing against breast cancer (MCF-7) cell lines which compound 14 (IC50=79.85, IC50=39) after 24 hours and 48 hours showed good cytotoxicity compared with drug reference tamoxifen. synthesized compounds 6-20 were evaluated for against antioxidant activity by using DPPH assay. In molecular docking, Promising compounds were used to reveal potential cytotoxic activity mechanisms.
Demokrasi dan Kontradiksi-Kontradiksinya, Perspektif Sejarah Filosofis Pierre Rosanvallon
Authors: Dua Mikhael
Published: June 2024

Abstract: This Article discusses on Pierre Rosanvallon’s conceptual history of democracy both as a method to understand the antinomy and the pathology of democracy and as a reflection of the generality of moral politics. For this purpose, the article will consist into three parts. The first one will deal with Rosanvallon’s conceptual history of democracy. The second part will delve into the problem of antinomy and pathology of democracy. And the third part will focus of the search for the normativity which is based on the moral generality. As conclusion, the article will invite the researchers to pay attention to the possibility of searching local wisdom as the clues to build the moral generality which is based on social relationship. 
The God of Process – the Interconnectedness of the World The Process Theology as A Frame for a Glocal Spirituality
Authors: Kleden Paul Budi
Published: June 2024

Globalization can be understood and experienced as homogenization of world cultures. However, globalization can also be perceived and lived as an opportunity given to the local cultures to express themselves at the global stage. The local cultures are enriched by the encounter with the other cultural traditions, while the global reality becomes more plural because of the contribution of different local cultures. This is what is meant by glocal, an interaction between the global and local contexts. To promote and live out such an interaction, a certain kind of spirituality is needed. The article suggests using process theology inspired by process philosophy of Alfred North Whitehead as the frame for developing such a spirituality.
Fibrolipoma vulvar pediátrico
Authors: Corimanya-Paredes Jorge Manuel , Urbina-Alvarez Claudia Aracelli , Veliz-Lazo Betty Delfina
Published: June 2024

Los fibrolipomas han sido descritos como subtipos histológicos del lipoma, son pocofrecuentes y se los considera neoplasias benignas mesenquimales. Se caracterizan porser tumoraciones que ocupan el plano subcutáneo y pueden aparecer en diferentespartes del cuerpo, pudiendo tener forma redonda, ovalada o multilobulada. Existepoca literatura sobre esta entidad clínica y no se ha informado su ocurrencia en laedad pediátrica. Se presenta el caso de una tumoración vulvar gigante en una niña de2 años que fue intervenida quirúrgicamente luego de un estudio minucioso apoyadopor ultrasonido Doppler y cuyo resultado histopatológico informó la presencia detejido adiposo maduro con tractos fibrosos, concluyéndose con el diagnóstico defibrolipoma de la vulva
Cómo entendemos la violencia obstétrica
Authors: Távara-Orozco Luis
Published: June 2024

Lo que es denominada violencia obstétrica preferimos llamarla violencia institucionalcontra la mujer durante la atención obstétrica, fundamentalmente para evitarlos estigmas contra los profesionales. Se han desarrollado investigaciones a nivelmundial sobre su ocurrencia, aunque en Latinoamérica existe limitada informaciónprocedente de trabajos de campo. No existe aún una definición consensuada a nivelde organizaciones de salud ni de organizaciones médicas, adoptándose diferentesdenominaciones para definirla. Su etiología es multifactorial y sus consecuencias sehallan a nivel físico, mental y sexual, pudiendo ocurrir en casos extremos la muertematerna y/o perinatal. En esta sección se revisa los diferentes componentes de estetipo de violencia y las medidas adoptadas para controlar su ocurrencia.
Detención puberal secundaria a prolactinoma gigante no tratado
Authors: Sarmiento-Piña Maira , Reyna-Villasmil Eduardo
Published: June 2024

Los tumores hipofisarios más comunes son los prolactinomas que rara vez seencuentran en niños y adolescentes. De manera similar, la hiperprolactinemia esuna endocrinopatía poco común en la infancia. La hipersecreción y producciónde prolactina, así como la compresión producida por el prolactinoma impidenel funcionamiento del eje hipotalámico-hipofisario-ovárico, probablementepor alteración de la pulsatilidad de gonadotropinas, junto con la presencia deinsuficiencia suprarrenal y tiroidea. Este síndrome funcional puede causar retraso dela pubertad, amenorrea primaria o secundaria, galactorrea y detención puberal. Laaparición de la telarquia y la pubarquia es a edades apropiadas, pero la detención deldesarrollo puberal antes de la menarquía es un trastorno poco frecuente conocidocomo detención puberal. Los agonistas dopaminérgicos son la primera opción detratamiento. Se presenta un caso de detención puberal secundario a prolactinomagigante no tratado.
COMBINATION OF HYPERTENSION AND DIABETES MELLITUS IN THE PRACTICE OF A FAMILY DOCTOR
Authors: Вовк К.В.  , Шерстюк Л.Л.  , Власенко О.О.  , Шумова Н.В.  , Резніченко О.Г.  , Кратенко Г.С.
Published: June 2024

The relationship between arterial hypertension (AH) and type 2 diabetes mellitus (T2DM) has long been established based on the results of large-scale epidemiological and population-based studies. The number of patients with hypertension in combination with type 2 diabetes mellitus has been steadily increasing in recent years, increasing the risk of developing both macro- and microvascular complications, which progressively worsens their prognosis. LDL cholesterol is also a prognostic indicator of stroke risk in type 2 diabetes with a combination of several risk factors (hypertension and dyslipidemia), and early detection and early prescription of lipid-lowering therapy for the treatment or prevention of cardiovascular disease is especially important. In the presented clinical case in the patient on the background of rosuvastatin and fenofibrate administration there was a significant positive change in triglycerides from 3.8 mmol/l to 1.34 mmol/l. The problem of treatment effectiveness and improving the prognosis of patients with diabetes and hypertension remains complex. Success in treatment depends on compliance with the following provisions: the effectiveness of the antihypertensive properties of drugs (antihypertensive, hypoglycemic, hypolipidemic), the ability to achieve the target level of office blood pressure, SBP, since patients with diabetes mellitus with hypertension are mostly non-dippers; achieving and maintaining high adherence to therapy for many years.
التشابه والتباين بين اللغة العربية واللغة الملايوية في بناء الجموع: دراسة تحليلية تقابلية
Authors: سيتي نور فاتحة بنت سهلن  , عبد الرحمن العثمان
Published: June 2024

الملخص
أظهرت الدراسات التقابلية السابقة أن هنالك تشابه وتباين في بناء الجموع بين اللغة العربية واللغات الأخرى. هدف هذا البحث إلى التعرف على التقابل اللغوي في بناء الجموع بين اللغة العربية واللغة الملايوية، وبيان أوجه التشابه والتباين بين اللغتين في بناء الجموع، مع عقد المقارنة بينهما من خلال تحليل الفروقات بين اللغتين المذكورتين. اعتمد الباحثان منهج التحليل التقابلي في دراسة أبنية الجموع بين اللغتين العربية والملايوية، حيث قاما بالمقابلة بين كيفية بناء الجموع، وتحليل النص في كلتا اللغتين. وقد نتج عن هذه الدراسة التقابلية مجموعة من النتائج، من أهمها: وجود مصطلحات خاصة للجموع في كلتا اللغتين، وأن التشابه في الجموع ظاهر بين اللغتين، وكذلك تباينها سواء في الأسماء أو الأعداد أو تكرار الكلمات، كما أوضحت النتائج أن أوجه التشابه والتباين بين أبنية الجموع في اللغتين يتجلى من خلال تحليل النص الأصلي للغة العربية وترجمته إلى اللغة المالايوية.
الكلمات المفتاحية: التشابه، التباين، بناء الجموع، دراسة تقابلية، التحليل التقابلي.
Financing trends of trade and logistics sector in developing countries:the case of Azerbaijan
Authors: Museyibov A. , Satiji A.
Published: June 2024

Object: The banking sector of Azerbaijan plays an important role in the stimulation of the economic development with a special accent to the sphere of the trade and logistics. This study touches on how the area augments economic growth largely through the adoption of the smart governmental interventions with the integration of digital advancements.
Methods: Applying the mixed-method approach, which entails both qualitative and quantitative research techniques, and taking data ranging from 2010 to 2022 from State Statistical Committee of Azerbaijan, World Bank and other financial reports and documents, the study set out to reveal main financial flows in sectors of overall economy of Azerbaijan. It tests the banking sector's finiding through the calculation of amount loaned to GDP, prudential lending with the ability to identify risks and thus contribute to the stability of the financial system and the subsidization of some financial services, especially in the rural areas.
Findings: The evaluation follows this up with an assessment of the performance of the private sector financing in this context, and how once substantial credit programs can be used in the betterment of the transport and logistics sector, among other things.
Conclusions: The research which merges macroeconomic factors with sector-specific details puts the emphasis on more favourable financing mechanisms to catalyse the exceptional growth in this township and suggests that we look constantly for pathways through complexities of economic development, logistics, and complexities.
The practice of Islamic taxation in Kazakhstan
Authors: Бурнашева Венера
Published: June 2024

Object: to study the experience of Islamic taxation and identifying possible ways of its application in improving the taxation system of the Republic of Kazakhstan.
Methods: Application of the method of generalization allowed to study the material consistently and build the overall structure of the study, the method of interpretation and comparison contributed to the evaluation of the scientists' positions and determination of the features of the development of Islamic taxation, which in comparison are comparable to the practice of development of the Kazakhstani taxation.
Findings: The presented interpretations and attitudes of Islamic taxation are interpreted on the modern system of taxation of the Republic of Kazakhstan. The comparative analysis of the Islamic system of taxation and the modern system of taxation of Kazakhstan was carried out. It was established that musharaka can act as a method of financing financial processes, and in taxation it implies a platform of interaction between the public revenue authority and the taxpayer. The essence of the risk management system and the necessity of its application in taxation were revealed. a set of tasks of Islamic taxation contributing to the strengthening of the system of taxation of the Republic of Kazakhstan was developed and recommended.
Conclusions: The results of the study confirmed that the Islamic system of taxation and the modern system of taxation of Kazakhstan have similar principles of taxation, with the application of the proposed set of tasks of Islamic taxation based on the Eisenhower matrix can affect the improvement of the indicators of the taxation system of the Republic of Kazakhstan in the future.
In vitro Propagation of Ornamental Snapdragon (Antirrhinum majus L.) Revisited: An Analysis on the Effects of Plant Growth Regulators
Authors: Kıymaz Gizem , Acemi Arda
Published: June 2024

The effects of N6-(2-isopentenyl) adenosine (IP) and p-chlorophenoxyacetic acid (CPA) on the propagation of Antirrhinum majus have yet to be elucidated. This study compares plant growth regulators’ effects on enhancing propagation efficiency in snapdragon. In the seedling development phase, IP at 1.0 mg L-1 provided the highest germination ratio (91.11 ± 9.30%). The 6-benzylaminopurine (BAP) treatment at 1.0 mg L-1 gave the highest number of shoots (4.42 ± 0.30) whereas the medium with 0.50 mg L-1 IP triggered shoot elongation (3.80 ± 0.28 cm) from germinating seeds. The medium with 1.0 mg L-1 IP gave the highest number of leaves (12.33 ± 1.77) and roots (2.96 ± 0.32). IP treatment at 0.50 mg L-1 produced the greatest increase in seedling root lengths (2.50 ± 0.31 cm). In the shoot multiplication phase, thidiazuron (TDZ) at 1.0 mg L-1 gave the maximum number of shoots (10.04 ± 2.42 per nodal explant) while BAP treatment at the same concentration triggered shoot elongation (5.99 ± 0.29 cm). In the rooting phase, 3-indoleacetic acid (IAA) treatment at 0.50 mg L-1 induced the highest rooting rate (100%), root production (4.93 ± 0.48 per shoot), and root length (7.16 ± 0.97 cm). IAA treatments did not trigger callus production. However, the CPA treatments induced consistently higher callogenesis responses (96% and 100%), resulting in a minimal rooting response. The findings suggested using IP to increase seedling development without causing a restriction in root development, TDZ to improve shoot multiplication efficiency, and CPA to produce high-frequency calli production in ornamental snapdragon.
Balıklardaki Biyojenik Aminlerin Halk Sağlığı ve Ticari Etkisi
Authors: Bozkurt Ramazan
Published: June 2024

Biyojenik Aminler (BA), su ürünlerinde, gıdalarda önemli biçimde üreyen Azot bileşimli organik bileşiklerdir. BA’lar, proteince zengin balık ve diğer gıdalardaki bakteriyel faaliyetlerle birlikte çeşitli kimyasal tepkimelerden oluşan dekarboksilasyonla oluşurlar. Biyojen aminler ton balığı, sardalya, uskumru gibi deniz balıklarında daha çok rastlanır. BA’ların varlığı aynı zamanda tüketilen bozulmuş meyve ve sebze gibi besinlerde de görüldüğü belirlenmiştir. Balıklarda oluşan bakteri kaynaklı histamin zehirlenmesi alerji ile birlikte aynı zamanda baş ağrısı, kızarma, karın krampları, hipertansiyon gibi çeşitli rahatsızlıklara da yol açmaktadır. Gündelik yaşamda tüketilen Uskumrugiller (Scrombridae) gibi balıklarda oluşan histaminler nedeniyle birçok balık zehirlenmesi durumu ortaya çıkmaktadır. Gıda güvenliği açısından sakıncalı olan BA’lar, balıklarla birlikte proteince zengin olan peynir, süt mamülleri, meyve-sebze ve diğer gıdalarda da oluşur. Genel olarak besinlerdeki 1000 mg/kg seviyesi ve üzeri, halk sağlığı açısından kritik ve tehlikeli bir düzey kabul edilir.
Towards a new theory of citizenship: migration rights in the chilean case
Authors: Rivera Cubillos Daniela
Published: June 2024

Introduction: This article investigates how migration processes impact human rights and redefine the conception of citizenship, using a qualitative case study based on the Chilean experience. Methodology: It applies a qualitative, descriptive and explanatory approach, analysing from a historical-theoretical perspective the contributions of classical sociologists on citizenship rights and how these have been influenced by migration. Analysis and Results: The analysis demonstrates that the traditional notion of citizenship, centred on residence, national identity and legal guarantees, is insufficient in the current context. The findings suggest that modern citizenship must transcend simple national membership and political participation, encompassing a broader spectrum of social and human dimensions. Conclusions: The study concludes that citizenship should not be viewed in a reductionist or exclusively legal manner, but as a multidimensional concept that needs to be rethought to reflect the realities of global migration and cultural interconnectedness. It highlights the need for a more inclusive and adaptive approach to citizenship in the contemporary world.
Surgical infarct volume reduction and functional outcomes in patients with ischemic cerebellar stroke: results from a multicentric retrospective study
Authors: Hernandez-Duran Silvia , Walter Johannes , Behmanesh Bedjan , Bernstock Joshua D. , Czabanka Marcus , Dinc Nazife , Dubinski Daniel , Freiman Thomas M. , Konczalla Juergen , Melkonian Ruzanna , Mielke Dorothee , Mueller Sebastian , Naser Paul , Rohde Veit , Senft Christian , Schaefer Jan Hendrik , Unterberg Andreas , Won Sae-Yeon , Gessler Florian
Published: June 2024

OBJECTIVE

Recent work on ischemic cerebellar stroke has suggested that the resection of infarcted tissue may lead to improved functional outcomes compared with decompressive surgery alone. Nonetheless, no studies have assessed the extent to which necrotic tissue should be resected or if there are any volumetric thresholds capable of predicting functional outcomes in this patient population. In this study, the authors aimed to determine potential thresholds for volume reduction in ischemic cerebellar stroke in an effort to optimize the management of ischemic cerebellar stroke and, in so doing, improve functional outcomes.

METHODS

This study is a multicentric retrospective study of patients who underwent surgery for the management of ischemic cerebellar stroke. Volumetric analyses of infarcted tissue present on CT scans were performed before and after surgical intervention(s). The final infarct volume (FIV) was computed as a percentage of the initial infarct volume (postoperative infarct volume/preoperative infarct volume × 100). The primary endpoint was functional outcome at 3 months, as determined by the modified Rankin Scale (mRS) score; mRS scores 0–2 were considered as favorable and mRS scores 3–6 as unfavorable. Receiver operating characteristic curves were used to explore the relationship between postoperative infarct volumes and FIV versus mRS score, and Youden’s index was used to estimate potential volumetric thresholds.

RESULTS

A total of 91 patients were included in the study. The mean pre- and postoperative infarct volumes were 45.25 (SD 18.32) cm3 and 29.56 (SD 26.61) cm3, respectively. Patients undergoing necrosectomy, regardless of whether via craniotomy or craniectomy, were more likely to have a favorable outcome at discharge (OR 16.62, 95% CI 2.12–130.33; p = 0.008) and at 3 months (OR 24.12, 95% CI 3.03–192.18; p = 0.003) postoperatively. Postoperative infarct volumes ≤ 17 cm3 yielded a sensitivity of 77% and a specificity of 68% with regard to the prediction of favorable outcome at 3 months. The resection ≥ 50% of infarcted tissue was also predictive of favorable outcomes at 3 months (OR 7.7, 95% CI 2.7–21.8; p < 0.001).

CONCLUSIONS

The reduction of necrotic tissue volumes by at least 50% and/or the reduction of the infarct volume by ≤ 17 cm3 appear to be associated with favorable outcomes in patients with surgically managed ischemic cerebellar strokes.
Hearing preservation outcomes using direct cranial nerve eight and auditory brainstem response neuromonitoring in the resection of vestibular schwannomas
Authors: Sloane Dayna C. , Nuru Mohammed , Pecoraro Nathan C. , Hand Rob , Strelko Oleksandr , Shin William Y. , Russ Adriana , Rajasekhar Rebecca , Jusue-Torres Ignacio , Hadjipanayis Constantinos , Leonetti John P. , Anderson Douglas E.
Published: June 2024

OBJECTIVE

Advancements in microsurgical technique and technology continue to improve outcomes in patients with skull base tumor. The primary cranial nerve eight monitoring systems used in hearing preservation surgery for vestibular schwannomas (VSs) are direct cranial nerve eight monitoring (DCNEM) and auditory brainstem response (ABR), although current guidelines are unable to definitively recommend one over the other due to limited literature on the topic. Thus, further research is needed to determine the utility of DCNEM and ABR. The authors performed a retrospective cohort study and created an interactive model that compares hearing preservation outcomes based on tumor size in patients receiving ABR+DCNEM and ABR-only monitoring.

METHODS

Twenty-eight patients received ABR+DCNEM and 72 patients received ABR-only monitoring during VS hearing preservation surgery at a single tertiary academic medical center between January 2008 and November 2022. Inclusion criteria consisted of adult patients with a preoperative American Academy of Otolaryngology–Head and Neck Surgery (AAO-HNS) hearing classification of A or B. Tumor size was measured as the maximal medial to lateral length, including the internal auditory canal component.

RESULTS

Overall hearing preservation (word recognition score [WRS] > 0%) was achieved in 31 patients with ABR-only monitoring (43.1%) and in 18 patients with ABR+DCNEM (64.3%). Serviceable hearing preservation (AAO-HNS class A or B) was attained in 19 patients with ABR-only monitoring (26.4%) and in 11 patients with ABR+DCNEM (39.3%). There was no difference in overall hearing preservation between the two groups (p = 0.13). Change in tumor size was not associated with the odds of serviceable hearing preservation for the ABR-only group (p = 0.89); however, for ABR+DCNEM, there was some indication of an interaction between tumor size and the association of ABR+DCNEM versus ABR-only monitoring, with the odds of serviceable hearing preservation at p = 0.089. Furthermore, with ABR+DCNEM, every 0.5-cm increase in tumor size was associated with a decreased odds of serviceable hearing preservation on multivariable analysis (p = 0.05). For both overall and serviceable hearing preservation, a worse preoperative AAO-HNS classification was associated with a decreased odds of preservation (OR 0.43, 95% CI 0.19–0.97, p = 0.042; OR 0.17, 95% CI 0.053–0.55, p = 0.0031, respectively).

CONCLUSIONS

The result of this interactive model study proposes that there may be a higher chance of hearing preservation when using ABR+DCNEM rather than ABR alone for smaller tumors, with that relationship reversing as tumor size increases.
The natural course, treatment outcomes, and long-term prognosis of cervical spinal cord arteriovenous shunts
Authors: Lu Hao-Han , Li Zheng-Song , Li Jing-Wei , Li Gui-Lin , He Chuan , Ye Ming , Hu Peng , Sun Li-Yong , Ma Yong-Jie , Ren Jian , Ling Feng , Zhang Hong-Qi , Yu Jia-Xing , Hong Tao
Published: June 2024

OBJECTIVE

The highly intricate nature of the cervical spinal cord can cause arteriovenous shunts in these segments that may be associated with heightened clinical risks and treatment complexities. In this article, the authors aimed to provide a comprehensive analysis of the detailed natural course, treatment, and clinical outcomes of cervical spinal cord arteriovenous shunts (SCAVSs) based on the largest cohort to date.

METHODS

Two hundred forty consecutive patients were included. Data on clinical presentation, angioarchitecture, treatment, and follow-up were retrospectively reviewed.

RESULTS

The cohort demonstrated a greater prevalence of acute onset (63.3% vs 36.7%). Spontaneous recovery was observed in 63.7% of patients after onset, with a significantly elevated recovery rate observed among patients experiencing acute onset (72.4% vs 48.9%, p < 0.001). The risks of acute and gradual clinical deterioration after onset was 11.9%/year and 13.4%/year, respectively. Microsurgery was performed in 39.6% of patients, while the remaining 60.4% exclusively underwent embolization. The complete obliteration rate was 65.3% after microsurgery and 21.4% after embolization. The rate of treatment-related deterioration was 14.7% after microsurgery and 6.2% after embolization. After partial treatment, the acute and gradual deterioration rates were 4.1%/year and 6.6%/year, respectively. Lack of spontaneous recovery after onset was an independent predictor of embolization-related deterioration (OR 17.905, p = 0.007) and long-term gradual deterioration after partial treatment (HR 2.325, p = 0.021). After a median follow-up period of 32.55 months, prognosis was unfavorable in 16.7% of patients, with the sole independent risk factor being the absence of spontaneous recovery after onset (OR 2.476, p = 0.018).

CONCLUSIONS

The outcomes of patients with cervical SCAVS were generally favorable, even in patients with only partial obliteration of the lesions. However, patients who did not show a trend toward spontaneous recovery after onset had a significantly elevated risk of unfavorable prognosis, highlighting the need for prompt clinical intervention.
Subventricular zone–associated classification in isocitrate dehydrogenase–wildtype glioblastomas: improved prognostic value through integration of FLAIR with contrast-enhanced imaging
Authors: Zhao Xuzhe , Ren Xiaohui , Li Mingxiao , Jiang Haihui , Li Ming , Wan Haibin , Zhang Yutao , Lin Song , Zhou Dabiao
Published: June 2024

OBJECTIVE

Controversy surrounds the prognostic value of contrast-enhanced T1-weighted (T1CE) imaging–based subventricular zone (SVZ) classification in isocitrate dehydrogenase (IDH)–wildtype glioblastomas (GBMs). In this study, the authors aimed to assess the potential of incorporating FLAIR imaging into T1CE imaging–based classification for improving prognostic accuracy.

METHODS

A retrospective analysis was conducted on 281 patients with IDH-wildtype GBM. T1CE imaging–based classification was performed, and T2-weighted/FLAIR imaging was integrated to evaluate its prognostic estimation ability. Based on the relationship between the tumors and SVZ, patients were categorized into SVZ+ and SVZ− cohorts based on T1CE and T2-weighted/FLAIR imaging findings. Kaplan-Meier and Cox proportional hazards regression analyses were used to assess progression-free survival (PFS) and overall survival (OS), respectively. Patients were then categorized into three subgroups based on their combined classifications: group 1 (SVZ+ on T1CE and T2-weighted/FLAIR imaging), group 2 (SVZ− on T1CE but SVZ+ on T2-weighted/FLAIR imaging), and group 3 (SVZ− on T1CE and T2-weighted/FLAIR imaging). Subgroup analysis was used to evaluate differences in clinical and molecular factors as well as in prognoses.

RESULTS

The T1CE imaging–based classification failed to stratify OS between SVZ+ and SVZ− cohorts (16.0 vs 20.0 months, p = 0.36). Survival analysis revealed similar prognoses for patients in groups 1 and 2, and patients in group 2 exhibited worse OS compared with those in group 3 (19.0 vs 23.5 months, p = 0.024). Logistic regression identified lower Karnofsky Performance Status (KPS) (p = 0.011), tumor diameter (p = 0.002), and telomerase reverse transcriptase (TERT) promoter mutation (p = 0.003) to be associated with a higher incidence of group 2 GBMs. Additionally, T2-weighted/FLAIR imaging–based classification provided significant prognostic value (17.0 vs 23.5 months p = 0.021) and was found to be an independent prognostic factor in the Cox multivariate analysis (HR 1.79, 95% CI 1.08–2.96; p = 0.024).

CONCLUSIONS

This study underscores the limitations of T1CE imaging–based SVZ-associated classification in predicting prognosis for IDH-wildtype GBMs. The authors therefore propose an integrated approach that involves T2-weighted/FLAIR imaging that can provide improved prognostic ability. Notably, the presence of TERT promoter mutation was identified as a critical factor in nonenhancing tumor infiltration into the SVZ. Further validation through extensive cohort studies is recommended to confirm these findings.
Full-endoscopic lumbar discectomy for lumbar disc herniation in young adults: 199 consecutive cases treated by a single surgeon with a mean 3.7-year follow-up
Authors: Feng Fei , Zhao Rugang , Dong Huajun , Yu Lingjia , Yang Yong , Tang Hai , Liu Xiaoguang , Zhu Bin
Published: June 2024

OBJECTIVE

Lumbar disc herniation (LDH) is rare in young adults. The present study aimed to evaluate the clinical outcomes of full-endoscopic lumbar discectomy (FELD) for LDH in young adults and to determine the risk factors that predict unfavorable outcomes of FELD for LDH in young adults.

METHODS

A retrospective two-center cohort study was performed between January 2015 and October 2021 at the authors’ institutions. Clinical outcomes were assessed using the visual analog scale (VAS) for low-back pain and leg pain and the Oswestry Disability Index (ODI). The modified Macnab criteria were used to evaluate clinical efficacy at the last follow-up, and the global outcomes were classified into 4 groups, namely excellent, good, fair, and poor. The fair and poor groups were defined as unfavorable outcomes.

RESULTS

One hundred ninety-nine patients were analyzed in this study (mean age 18.5 years, mean BMI 25.1 kg/m2, male/female sex ratio 2.8). The duration from the onset of symptoms to the operation was in general prolonged with age. The VAS and ODI scores significantly improved after surgery. A total of 17 of 195 single-segment cases had unfavorable outcomes based on the modified Macnab criteria. Lateral disc herniation (OR 3.72, 95% CI 1.14–12.12, p = 0.029) and high preoperative VAS score (OR 1.98, 95% CI 1.13–3.46, p = 0.017) were identified as risk factors for unfavorable outcomes after FELD.

CONCLUSIONS

FELD for LDH in young adults is safe and effective. Preoperative VAS score and lateral disc herniation are risk factors of nonfavorable outcomes after surgery and may be a useful index for surgical procedure selection.
TÜRKİYE’DE REKLAM MÜZİĞİ ALANINDA ÇALIŞAN ARANJÖRLERİN REKLAM MÜZİĞİ KONUSUNDAKİ GÖRÜŞLERİNİN İNCELENMESİ
Authors: Can Kubilay , Çelikkan Işıl
Published: June 2024

Bu araştırmada Türkiye’de reklam müziği alanında çalışmakta olan aranjörlerin bu konudaki görüşleri incelenirken, aranjörlerin oluşturduğu reklam müziklerinin iş geliş, planlama ile başlangıç ve bitişine kadar olan süreci, beklenen reklam müziklerinin içerik ve müzikal özellikleri ve elde edilen ürünlerin kalitesi ve geri bildirimlerine yönelik hususların neler olduğu üzerinde durularak, aranjörlük mesleği ve reklam müziği konularında daha detaylı bilgi edinilmesi amaçlanmıştır. Araştırma sonuçları müzik bilimi alanında bundan sonraki yapılacak çalışmalara önemli bir veri oluşturacağı ve giderek gelişmekte olan reklam sektöründe yerini almak isteyen aranjör adaylarına ışık tutması açısından faydalı olduğu düşünülmektedir. Bu çalışmada model olarak nitel araştırma türlerinden fenomonoloji deseni tercih edilmiştir. Araştırmanın çalışma grubunun oluşturulmasında amaçlı örnekleme yöntemi kullanılmıştır. Örneklem olarak seçilen 8 aranjör ile görüşmeler 24 maddelik bir yapılandırılmış görüşme formu kullanılarak gerçekleştirilmiştir. Araştırmanın çalışma grubunu oluşturan 8 aranjör katılımcı Türkiye’de 16 ila 26 yıldır aranjörlük mesleğinde yer alan ve en az 5 senedir özellikle reklam müziği konusunda çalışmakta olan müzisyenlerden seçilmiştir. Görüşme formunun oluşturulmasında katılımcıların fiziki ve teknik imkânları, bilgi ve donanımları, reklam müziğinin dikkat çekici özellikleri ve Türkiye’de reklam müziğinin güncel durumu boyutlarından yararlanılmıştır. Bu veriler doğrultusunda katılımcıların ortak ve farklı görüşleri belirlenerek veriler kodlanmış, birbirleriyle ilişkili kodlar birleştirilerek elenmiş ve temalar oluşturulmuştur. Elde edilen sonuçlar bulgular bölümünde tablolarla gösterilmiştir. Çalışma sonucunda, reklam müzikleri konusunda her geçen gün dünya standartlarına yaklaşıldığı ülkemizde, bu sektörde ortaya konan başarılı ürünler göz önünde bulundurularak; aranjörlük mesleği ile ilgili çalışmaların uluslararası düzeye taşınması ve daha geniş kitlelere hitap edilmesi amacı ile aranjörlük mesleği üniversitelere bağlı akademik birimlerde yer alması önerilmiştir.
TÜRK MÜZİĞİ SOL KLARNET EĞİTİMİNDE ÖĞRETİM PROGRAMI TASARISINA YÖNELİK İHTİYAÇ ANALİZİ
Authors: Sopaoğlu Ufuk , Özdek Attila
Published: June 2024

Bu çalışmanın amacı, başlangıç düzeyi Türk müziği sol klarnet eğitimine yönelik öğretim programının ihtiyaçlarını belirlemektir. Bu amaçla nitel araştırma yöntemlerinden biri olan tarama modelli bir yaklaşım benimsenmiştir. Araştırma verileri yarı yapılandırılmış görüşme formu aracılığıyla elde edilmiştir. Dört akademisyene konuya ilişkin sekiz soru sorulmuş ve görüşmelerin ses kayıtları içerik analizi tekniğiyle çözümlenerek değerlendirilmiştir. Araştırmanın çalışma grubu evrenin tamamını temsil etmektedir. Araştırma sonucunda; başlangıç düzeyinde Türk müziği sol klarnet eğitiminde; eğitimcilerin kendi oluşturdukları öğretim programlarını uyguladıkları, buna bağlı olarak öğrencilerin bireysel farklılıklarını göz önünde bulundurma gayretinden dolayı da uyguladıkları öğretim programlarında daha esnek ve pratik bir yaklaşım benimsedikleri Türk müziği klarnet eğitimcileri öğretim programlarını hazırlarken; öğrencilerin kaliteli sesler üretebilmesi, entonasyonlarını geliştirebilmesi ve enstrümanlarında ustalık kazanabilmesi için duruş, tutuş, nefes alma ve tonal müzik odaklı uygulamalara önem verdikleri anlaşılmıştır.
OTİZM VE MÜZİĞE İLİŞKİN META SENTEZ ÇALIŞMASI
Authors: Ergül Ebru , Öztosun Çaydere Öznur
Published: June 2024

Müzik, duygu ve düşüncelerin sesler yoluyla ifade edilmesi, bir nevi dışavurumudur. Yapılan araştırmalar küçük yaşlarda müzik eğitimi almış, bir enstrüman çalmayı öğrenmiş çocukların beyin gelişimlerinin, el göz koordinasyonlarının, motor becerilerinin ve problem çözme yetilerinin olumlu yönde geliştiğini ortaya koymuştur. Sağlıklı çocuklarda olumlu etkilerini gördüğümüz müzik uygulamalarının, özel eğitim gerektiren otistik çocuklarda da oldukça etkili bir yöntem olduğu bilinmektedir. Bu araştırma otizm ve müzik konusunda yapılan makalelere ilişkin bir meta sentez çalışması yapmayı amaçlamaktadır. Araştırmada meta sentez modeli kullanılmıştır. Veriler doküman analizi yoluyla toplanmıştır. PubMed veri tabanından “otizm ve müzik” anahtar kelimeleriyle elde edilen, 433 veriden açık erişimi olan, müzikal uygulama içeren, 2017 ve sonrasında yayımlanan toplam 12 çalışma araştırmanın örneklemini oluşturmaktadır. Veriler içerik analizi yoluyla çözümlenmiştir. İçerik analizi kapsamında elde edilen temalar alt problemleri oluşturmaktadır. Bulgular alt problemler yoluyla raporlanarak sonuçlanmıştır. Araştırma sonuçlarına göre, incelenen çalışmalarda daha çok örneklem ve kontrollü son test model kullanıldığı, tüm çalışmalarda otizm tanı teşhis ölçeklerine yer verildiği, bunun dışında en çok sosyal beceri ölçeklerinin kullanıldığı, katılımcıların yaş aralıklarının en az 2 en fazla 12 olduğu, daha çok hafif ve orta derecede otizmli bireylerin ele alındığı, incelenen çalışmalardaki müzikal uygulamalarda şarkı söyleme, dinleme, enstrüman çalma, vokal ve enstrümantal doğaçlama ve müzik terapi yöntemlerine yer verildiği, bu uygulamalarda yapılandırılmış ya da bilinen şarkıların, orff enstrümanlarının, klasik müzik eserlerinin ve ritim kalıplarının materyal olarak kullanıldığı, ayrıca çalışmalarda müzik terapistlerinin yanında, fizyoterapistlerin, konuşma ve dil terapistlerinin, müzik öğretmenleri ve müzik uzmanlarının da görev aldığı ve müzikal uygulamaların otizmli bireylerin sosyal beceriler, sosyal iletişim, davranış bozuklukları, konuşma ve dil becerileri, motor becerileri gibi özelliklerini geliştirdiği tespit edilmiştir ancak araştırma kapsamında olumsuz sonuçlanan çalışmalar da olduğundan konu ile ilgili daha fazla sayıda çalışmanın yapılması önerilmektedir.
MÜZİK ÖĞRETMENLİĞİ PROGRAMI YETENEK SINAVLARI İÇİN GEREKEN TYT SIRALAMASI ÖN KOŞULUNUN ÖĞRETMEN GÖRÜŞLERİ DOĞRULTUSUNDA İNCELENMESİ
Authors: Apaydın Ali Kerem , Yazıcı Derya
Published: June 2024

Yurdumuzdaki üniversitelerin müzik öğretmenliği anabilim dalları, özel yetenek sınavıyla öğrenci alan ve müzik öğretmeni yetiştiren programlardır. 2020-YKS ile birlikte bu programların yetenek sınavlarına girebilmek için TYT’de ilk 800.000 kişi arasına girme ön koşulu getirilmiştir. Bu durum; güzel sanatlar liselerinin, eğitim fakültelerinin müzik öğretmenliği programlarına öğrenci hazırlaması noktasında bazı etkilere sebep olmuştur. Nitel bir durum çalışması olan bu araştırma, müzik öğretmenliği yetenek sınavı için ön koşul olan TYT’de ilk 800.000 barajının öğrenciler ve güzel sanatlar liselerinin müzik öğretmenliği programına öğrenci yetiştirme durumları üzerindeki etkisinin öğretmen görüşleri doğrultusunda incelenmesini amaçlamaktadır. Bu amaç doğrultusunda 2022-2023 eğitim-öğretim yılında güzel sanatlar liselerinden mezun olan ve müzik öğretmenliği anabilim dalına yerleşen öğrenci sayılarını tespit etmek için 44 güzel sanatlar lisesinden veri toplanmıştır. Öte yandan 800.000 barajının, güzel sanatlar liseleri öğrenci ve öğretmenleri üzerindeki etkisini ortaya çıkarmak için bu kurumlarda görev yapan 7 kültür ve 7 meslek dersi öğretmeni ile 6 soruluk yarı yapılandırılmış görüşme yapılmıştır. Elde edilen veriler betimsel analiz yöntemi kullanılarak kategorize edilmiş ve frekans değerlerinden oluşan tablolar hâlinde sunulmuştur. Araştırmada güzel sanatlar liselerinden mezun olan öğrencilerin %9’nun TYT’de ilk 800.000 barajını geçtiği, bu öğrencilerin de %86’sının müzik öğretmenliği bölümlerine yerleştiği belirlenmiştir. Buna bağlı olarak müzik öğretmenliği anabilim dalı programlarının kontenjan sayılarının azaldığı tespit edilmiştir. Görüşme yapılan öğretmenlerin çoğunluğu, nitelikli öğretmen yetişmesi noktasında katkı sağlayacağı gerekçesiyle 800.000 barajını gerekli gördüklerini belirtmiş, ancak barajın öğrencilerde stres, gelecek kaygısı ve meslek seçimlerinde özensiz davranma gibi olumsuz durumlara neden olduğu sonucuna ulaşılmıştır. Araştırma kapsamında ulaşılan sonuçlardan hareketle öneriler sunulmuştur.
Спектральные и фотохимические свойства супрамолекулярной диады с пиренилэтенилхинолином в качестве фотохрома: влияние структуры мостиковой группы
Authors: Будыка М. Ф. , Ли В. М. , Гавришова Т. Н.
Published: June 2024

Исследованы спектральные и фотохимические свойства бифотохромной диады, в которой два фотохрома – 2-[2-(пирен-1-ил)этенил]-хинолина (PEQ) – соединены между собой орто-ксилиленовой связывающей группой. По батохромному сдвигу спектра флуоресценции в диаде зафиксирован эксимер. Под действием света в диаде происходят реакции фотоизомеризации PEQ фотохромов и внутримолекулярного [2+2]-фотоциклоприсоединения (ФЦП) с образованием дипиренил-замещенного циклобутана. Предположено, что склонность PEQ-фотохромов к p-стэкинг взаимодействию оказывает положительное влияние на первом этапе реакции ФЦП, способствуя образованию предорганизованных димерных структур в основном S0 состоянии, которые дают эксимер в возбужденном S1 состоянии, но отрицательное влияние на втором этапе реакции, препятствуя перемещению фотохромов относительно друг друга, которое необходимо для достижения конформаций, благоприятствующих реакции ФЦП.
PECULIARITIES OF THE UNIVERSITIES' MANAGEMENT LOCATED ON FRONTLINE TERRITORIES
Authors: AZHAZHA Maryna , PELIOVA Jana , NESTORENKO Tetyana , KAPLUNOVSKA Alla , KRAVCHYK Yurii
Published: June 2024

The article analyzes the peculiarities of the management of universities (including displaced ones) located on the frontline territories, in the conditions of the war between Russia and Ukraine. It has been found that universities in these regions face unique challenges that require adaptation and the development of new management strategies, such as ensuring physical security, psychological support, infrastructure restoration, providing access to communications, quality educational services, hybrid learning models, scientific activities, financing and adaptation to new conditions. It is justified that the research is determined by the need for prompt response to security threats, ensuring the continuity of the educational process, infrastructure restoration, personnel support, international cooperation, development of innovative solutions, and socio-economic stability of the regions. The analysis and systematization of specific aspects of the management of higher education institutions operating in the frontline territories aimed at identifying key challenges and developing effective strategies for overcoming them was carried out. It has been proven that university management includes normative-procedural, structural-functional, and strategic-organizational processes. Peculiarities of the processes of implementation of innovative educational activities and conducting scientific research in universities located in the frontline territories were studied. Synergistic, systemic, statistical, comparative, and functional methods were used for the research. It is found that the synergistic method integrates various management components such as organizational, financial, personnel, and infrastructure management to create a holistic picture of wartime management. The system method allows you to consider the university as a whole system interacting with the environment, using interviews, discussions, surveys, and statistical analysis to collect data. The statistical method evaluates the impact of various factors on university management through quantitative data using means, medians, variances, regression models, and statistical tests. The comparative method analyzes and compares management practices, identifying the best of them to improve efficiency. The functional method assesses the effectiveness of key management functions such as planning, organization, resource allocation, communication, and control. It was found that the methodology for researching the peculiarities of the management of universities in the frontline territories involves a comprehensive approach, which includes the collection of primary and secondary data, qualitative and quantitative analysis, the development of recommendations and their validation, which provides a deep understanding of the problem and the development of effective strategies for the support and development of universities in war conditions.
ПОТЕНЦІАЛ ТРИВОГИ У ВИМІРАХ СОЦІАЛЬНО-ПСИХОЛОГІЧНОЇ АДАПТАЦІЇ ТВОРЧОЇ ОСОБИСТОСТІ
Authors: АФАНАСЕНКО Валентина , КОМАР Таїсія , ПИРОГОВ Олег
Published: June 2024

Стаття присвячена висвітленню результатів наукової розробки проблеми тривоги особистості в контексті її соціально-психологічної адаптації та реалізації творчого потенціалу.
У статті розкрито взаємозв’язок творчого потенціалу людини і тривоги та уявлення про роль тривоги у процесі її адаптації представлено на основі аналізу праць філософів – екзистенціалістів, представників психодинамічних підходів, сучасних дослідників. Вказано на необхідність розвитку творчого потенціалу людини через усвідомлення сутності своєї тривоги та розуміння її справжніх причин.
Основна ідея статті полягає у розгляді тривоги як психологічного феномену, потенціал якого розгортається на континуумі від внутрішньої енергетичної спонуки з функцією творчого імпульсу до хворобливого утворення, що ґрунтує депресії і психосоматичні розлади.
Автори статті вбачають у творчому потенціалі особистості істотний резерв людської цивілізації, провідну силу прогресивного розвитку кожної людини і продуктивної адаптації до актуальних соціально-психологічних умов дійсності. Творча діяльність постає тим самим механізмом, що протистоїть регресивним лініям у розвитку людини, може бути високо спроможним засобом психологічної реабілітації та збереження психологічного здоров’я.
ОСВІТНІЙ МЕНЕДЖМЕНТ: ТЕНДЕНЦІЇ ВИКОРИСТАННЯ ТЕХНОЛОГІЙ УПРАВЛІННЯ В СПЕЦІАЛЬНИХ ЗАКЛАДАХ ОСВІТИ ТА ІНКЛЮЗИВНО-РЕСУРСНИХ ЦЕНТРАХ
Authors: ОЛІЙНИК Марія , ЧЕБЕНЄЄВА Аліна
Published: June 2024

У статті розглядається сутність освітнього менеджменту і проводиться оцінка ефективності його використання в сучасних умовах управління в спеціальних закладах освіти та інклюзивно-ресурсних центрів. Зазначається, що управління освітніми інноваціями ґрунтується на певних принципах, що виступають як норми та орієнтири, зокрема: гуманізм, демократизм, національна спрямованість, єдність загальнолюдського і національного характеру навчання, співтворчість, життєтворчість, диференціація та індивідуалізація, оптимізація й відкритість, інноваційність.
Акцентується важливість управління спеціальними закладами освіти та інклюзивно-ресурсними центрами, підкреслюючи необхідність спрямованості керівника на цілеспрямовану й активну співпрацю з іншими учасниками освітнього процесу з метою забезпечення координації дій для оптимального функціонування закладами та підвищення її якості.
Проаналізовано організаційний, інформаційний та комунікаційні аспекти управління спеціальними закладами та інклюзивно-ресурсними центрами, а також вказується на перспективи майбутніх досліджень у сфері формування нової управлінської культури, яка є необхідною для ефективного управління такими закладами, а також основні напрями розвитку освітнього менеджменту в системі інклюзивної освіти.
ОСОБЛИВОСТІ СПРИЙМАННЯ У ДІТЕЙ МОЛОДШОГО ШКІЛЬНОГО ВІКУ В УМОВАХ ВОЄННОГО ЧАСУ
Authors: ТЕСЛИК Наталія , ГУНБІНА Ганна , ЧЕРНИШ Софія
Published: June 2024

Розглянуто психологічні особливості сприймання дітей молодшого шкільного віку як психологічна категорія. Визначено специфічні прояви та сутнісні вікові закономірності сприймання у системі когнітивного розвитку молодших школярів. Проаналізовано психологічно значимі причини вразливості розвитку дитини, в тому числі і когнітивного, у період воєнного часу. Реалізоване емпіричне дослідження особливостей сприймання дітей молодшого шкільного віку, які проживають на території України, а також тих, родини яких отримали тимчасовий притулок від війни на території Данії.   Емпіричним шляхом доведено, що психологічна підтримка когнітивного розвитку дітей  молодшого шкільного віку має будуватися на урахуванні чинника місця проживання. Зокрема, діти, які  вимушено мігрували внаслідок військової агресії проти України, оскільки частково виявляють нижчий рівень та потребують підтримки розвитку сприймання.