A Simple Clinical Predictive Model for Arthroscopic Mobility of Osteochondritis Dissecans Lesions of the Knee
Authors: Milewski Matthew D. , Miller Patricia E. , Gossman Emma C. , Coene Ryan P. , Tompkins Marc A. , Anderson Christian N. , Bauer Kathryn , Busch Michael T. , Carey James L. , Carsen Sasha , Chambers Henry G. , Coene Ryan P. , Edmonds Eric W. , Ellermann Jutta , Ellis Jr Henry B. , Erickson John , Fabricant Peter D. , Ganley Theodore J. , Gossman Emma C. , Green Daniel W. , Heyworth Benton E. , Hoi Po Hui James , Kocher Mininder S. , Krych Aaron J. , Latz Kevin , Lyon Roger M. , Mayer Stephanie , Milewski Matthew D. , Miller Patricia E. , Nelson Bradley J. , Nepple Jeffrey J. , Nguyen Jie C. , Nissen Carl W. , Lee Pace James , Paterno Mark V. , Pennock Andrew T. , Perkins Crystal , Polousky John D. , Saluan Paul , Shea Kevin G. , Tompkins Marc A. , Wall Eric J. , Weiss Jennifer M. , Willimon Clifton , Wilson Philip , Wright Rick W. , Zbojniewicz Andy , Myer Gregory D. 
Published: November 2024

Background:

Osteochondritis dissecans (OCD) of the knee is a focal idiopathic alteration of subchondral bone and/or its precursor with risk for instability and disruption of adjacent cartilage. Treatment options focused on preventing premature osteoarthritis vary depending on multiple patient and lesion characteristics, including lesion mobility.

Purpose:

To differentiate lesion mobility before arthroscopy using a multivariable model that includes patient demographic characteristics and physical examination findings.

Study Design:

Cohort study (Diagnosis); Level of evidence, 2.

Methods:

Demographic, preoperative physical examination, and radiographic data were collected from a multicenter national prospective cohort of patients with OCD of the knee. Inclusion criteria included patients <19 years of age and patients with arthroscopically confirmed mobility status based on the Research on Osteochondritis Dissecans of the Knee arthroscopy classification. Multivariable logistic regression analysis using stepwise model selection was used to determine factors associated with the likelihood of a mobile versus an immobile lesion. A 75% partition of the data was used for model training, and 25% was used as a validation cohort. Quantitative model fit statistics were computed using the holdout data, including sensitivity, specificity, and the area under the receiver operating characteristic curve (AUC), along with the corresponding 95% CI.

Results:

A total of 407 patients in the prospective cohort met inclusion criteria, and 62% were male. The mean ± SD age was 13.7 ± 2.2 years, height 161.8 ± 5.3 cm, and weight 59.2 ± 42.2 kg. Arthroscopic evaluation yielded 235 immobile and 172 mobile lesions. Multivariable analysis determined that the best model to predict lesion mobility included chronologic age ≥14 years ( P < .001), effusion on physical examination ( P < .001), and any loss of range of motion on physical examination ( P = .07), while controlling for male sex ( P = .38) and weight >54.4 kg ( P = .12). In the 25% holdout validation sample (n = 102), a sensitivity of 83%, a specificity of 82%, and an AUC of 0.89 (95% CI, 0.82-0.95) were achieved with these predictive factors.

Conclusion:

Age, effusion, and loss of motion can predict knee OCD lesion mobility at the time of arthroscopy. Education about lesion mobility can help with surgical planning and patient and family counseling.