bluuebunny/crossref_metadata_2025 huggingface dataset:
Sarcopenia and Nutrition in Elderly Rheumatoid Arthritis Patients: A Cross-Sectional Study to Determine Prevalence and Risk Factors
Authors: Cano-García Laura , Manrique-Arija Sara , Domínguez-Quesada Carmen , Vacas-Pérez Juan Crisóstomo , Armenteros-Ortiz Pedro J. , Ruiz-Vilchez Desiré , Martín-Martín José María , Redondo-Rodríguez Rocío , García-Studer Aimara , Ortiz-Márquez Fernando , Mena-Vázquez Natalia , Fernández-Nebro Antonio
Published: May 2023

Objective: To describe the prevalence of sarcopenia in rheumatoid arthritis (RA) patients aged ≥65 years and identify the risk factors associated with sarcopenia. Methods: This is a multicenter, controlled, cross-sectional study of 76 RA patients and 76 age- and sex-matched healthy controls. Sarcopenia was defined according to the revised criteria of the European Working Group on Sarcopenia in Older People (EWGSOP2). Whole-body dual-energy X-ray absorptiometry (DXA) was performed. Binary regression was used to assess the relationship between sarcopenia and sex, age, duration of RA, Mini Nutritional Assessment (MNA) score, and Short Physical Performance Battery (SPPB) score in patients with RA. Results: Nearly 80% of participants were female, and the average age was >70 years. Patients with RA had lower muscle mass and greater adiposity (fat-to-muscle ratio mean [SD] 0.9 [0.2] vs. 0.8 [0.2]; p = 0.017) than controls, mainly in the central area (android/gynoid ratio, median [p25–p75]: 1.0 [0.9–1.2] vs. 0.9 [0.8–1.1]; p < 0.001). Twelve patients (15.8%) and three controls (3.9%) had confirmed sarcopenia (p = 0.014). Sarcopenic obesity was observed in 8/76 patients with RA (10.5%) and in 1/76 controls (1.3%) (p = 0.016). The factors associated with sarcopenia were male sex (OR [95% CI]: 9.3 [1.1–80.4]; p = 0.042), disease duration (OR [95% CI]: 1.1 [1.0–1.2]; p = 0.012), and nutritional status according to the MNA (OR [95% CI]: 0.7 [0.5–0.9]; p = 0.042). Conclusions: Our results suggest that patients with RA aged ≥65 years may be at increased risk for sarcopenia, adiposity, and malnutrition (especially male patients with long-standing disease) and have poor nutritional status.
Nutritional Aspects of Iron in Health and Disease
Authors: Charlebois Edouard , Pantopoulos Kostas
Published: May 2023

Dietary iron assimilation is critical for health and essential to prevent iron-deficient states and related comorbidities, such as anemia. The bioavailability of iron is generally low, while its absorption and metabolism are tightly controlled to satisfy metabolic needs and prevent toxicity of excessive iron accumulation. Iron entry into the bloodstream is limited by hepcidin, the iron regulatory hormone. Hepcidin deficiency due to loss-of-function mutations in upstream gene regulators causes hereditary hemochromatosis, an endocrine disorder of iron overload characterized by chronic hyperabsorption of dietary iron, with deleterious clinical complications if untreated. The impact of high dietary iron intake and elevated body iron stores in the general population is not well understood. Herein, we summarize epidemiological data suggesting that a high intake of heme iron, which is abundant in meat products, poses a risk factor for metabolic syndrome pathologies, cardiovascular diseases, and some cancers. We discuss the clinical relevance and potential limitations of data from cohort studies, as well as the need to establish causality and elucidate molecular mechanisms.
Dietary Long-Chain Fatty Acids Accelerate Metabolic Dysfunction in Guinea Pigs with Non-Alcoholic Steatohepatitis
Authors: Pedersen Kamilla , Ipsen David Højland , Skat-Rørdam Josephine , Lykkesfeldt Jens , Tveden-Nyborg Pernille
Published: May 2023

The composition of dietary fatty acids may be important for the development and progression of metabolic syndrome and non-alcoholic steatohepatitis (NASH). This study investigated the effect of two high-fat diets based on coconut oil, containing predominantly medium-chain fatty acids (MCFA), or cocoa butter, containing mainly long-chain fatty acids (LCFA), on glucose homeostasis and NASH in guinea pigs following 16 and 32 weeks of diet. At week 16, glucose intolerance was increased in the LCFA animals compared to the MCFA animals (p < 0.001), with both groups differing from the controls by week 32 (p < 0.0001), supported by increased hemoglobin A1c (p < 0.05). NASH was present in both high-fat groups from week 16, with advancing fibrosis appearing more progressive in the LCFA animals at week 16. In agreement, gene expression showed overall increased expression of NASH target genes in the LCFA animals compared to the MCFA animals at weeks 16 and 32 (p < 0.05 and p < 0.0001, respectively). The LCFA animals also displayed increased plasma uric acid at both time points (p < 0.05), a phenomenon linked to NASH in humans. In conclusion, this study reports that a diet high in LCFA promotes metabolic imbalance and may accelerate NASH-associated hepatic fibrosis. This highlights the importance of a critical evaluation of fatty acid composition when investigating NASH-associated endpoints.
Post-Marketing Use of Teduglutide in a Large Cohort of Adults with Short Bowel Syndrome-Associated Chronic Intestinal Failure: Evolution and Outcomes
Authors: de Dreuille Brune , Nuzzo Alexandre , Bataille Julie , Mailhat Charlotte , Billiauws Lore , Le Gall Maude , Joly Francisca
Published: May 2023

Teduglutide, a GLP-2 analogue, has been available in France since 2015 to treat short-bowel-syndrome (SBS)-associated chronic intestinal failure (CIF) but it remains very expensive. No real-life data on the number of potential candidates are available. The aim of this real-life study was to assess teduglutide initiation and outcomes in SBS-CIF patients. All SBS-CIF patients cared for in an expert home parenteral support (PS) center between 2015 and 2020 were retrospectively included. Patients were divided into two subpopulations: prevalent patients, already cared for in the center before 2015, and incident patients, whose follow-up started between 2015 and 2020. A total of 331 SBS-CIF patients were included in the study (156 prevalent and 175 incident patients). Teduglutide was initiated in 56 patients (16.9% of the cohort); in 27.9% of prevalent patients and in 8.0% of incident patients, with a mean annual rate of 4.3% and 2.5%, respectively. Teduglutide allowed a reduction in the PS volume by 60% (IQR: 40–100), with a significantly higher reduction in incident versus prevalent patients (p = 0.02). The two- and five-year treatment retention rates were 82% and 64%. Among untreated patients, 50 (18.2%) were considered ineligible for teduglutide for non-medical reasons. More than 25% of prevalent SBS patients were treated with teduglutide compared to 8% of incident patients. The treatment retention rate was >80% at 2 years, which could be explained by a careful selection of patients. Furthermore, this real-life study confirmed the long-term efficacy of teduglutide and showed a better response to teduglutide in incident patients, suggesting a benefit in early treatment.
The Correlation between Adolescent Daily Breakfast Consumption and Socio-Demographic: Trends in 23 European Countries Participating in the Health Behaviour in School-Aged Children Study (2002–2018)
Authors: Lazzeri Giacomo , Ciardullo Silvia , Spinelli Angela , Pierannunzio Daniela , Dzielska Anna , Kelly Colette , Thorsteinsson Einar B. , Qirjako Gentiana , Geraets Anouk , Ojala Kristiina , Rouche Manon , Nardone Paola
Published: May 2023

Breakfast is often considered the most important meal of the day and can benefit adolescent health in several ways. The aims of the present study were (1) to identify adolescents’ socio-demographic (sex, family affluence and family structure) determinants of daily breakfast consumption (DBC) and (2) to describe trends in DBC among adolescents across 23 countries. Cross-sectional surveys of nationally representative samples of adolescents (aged 11, 13, and 15 years) (n = 589,737) participating in the Health Behaviour in School-aged Children (HBSC) survey from 2002 to 2018 were used. Multilevel logistic regression analyses modeled DBC over time, adjusted for family affluence, family structure and year of survey. Four countries showed an increased trend in DBC (the Netherlands, Macedonia, Slovenia, and England). A significant decrease in DBC was observed in 15 countries (Belgium-Fr, France, Germany, Croatia, Portugal, Spain, Hungary, Poland, Russian Federation, Ukraine, Denmark, Finland, Latvia, Lithuania and Sweden). In 4 countries no significant change was observed (Czech Republic, Scotland, Ireland and Norway). In most of the countries (n = 19), DBC was higher among the adolescents from high-affluence homes. In all the countries analysed, the adolescents living in two-parent households report higher DBC use than those in single-parent households. More than half of the countries showed a decrease in DBC. There is a need to implement key interventions by developing different strategies (education, incorporating educational curriculum and counselling programmes) to increase DBC. Comparing DBC patterns across HBSC countries is important for understanding regional and global trends, monitoring strategies, and developing health promotion programmes.
Determinants of Adherence to a Gluten-Free Diet in Children with Celiac Disease and the Influence of the Methods Used to Assess It
Authors: Monzani Alice , Marcolin Silvia , Giorda Sara , Epis Francesco , Babral Maristella , Valentino Kevin , Scotti Lorenza , Felici Enrico , Rabbone Ivana
Published: May 2023

Lifelong adherence to a gluten-free diet (GFD) is the cornerstone of management of celiac disease (CD), but adhering to a GFD can be hard. Although several factors are positively associated with adherence of pediatric CD patients to a GFD, it is unknown whether these are influenced by variability caused by the specific tool used to assess adherence to a GFD. Here, we aimed to evaluate how individual patient characteristics and dietary counselling by a trained dietitian influence adherence to a GFD in children with CD, as assessed by two validated questionnaires: the Biagi questionnaire and the Leffler short questionnaire adapted for pediatric patients. Some 139 children and adolescents were recruited in a cross-sectional, multicenter study. Concordance between the two questionnaires in defining adherence was fair (weighted Cohen’s kappa coefficient 0.39, 95%CI 0.19–0.60). Upon regression analysis, having a cohabiting family member with CD, being of Italian origin, and receiving specialized dietary counselling during follow-up were found to positively influence stricter adherence to a GFD for children with CD. Neither questionnaire detected a significant relationship between adherence to a GFD and the presence of symptoms after gluten ingestion. This study provides important new data on the factors influencing GFD adherence in the pediatric population, and highlights the importance of dietician input and overcoming language and cultural barriers when educating patients.
Evaluation of Subjective Appetite Assessment under Free-Living vs. Controlled Conditions: A Randomized Crossover Trial Comparing Whole-Grain Rye and Refined Wheat Diets (VASA-Home)
Authors: Åberg Sebastian , Palmnäs-Bédard Marie , Karlsson Therese , Hjorth Thérése , Iversen Kia Nøhr , Landberg Rikard
Published: May 2023

Background: Accurate assessment of self-reported appetite under free-living conditions is warranted to conduct large-scale intervention studies measuring appetite at a feasible cost. However, the performance of visual analogue scales (VASs) for this purpose has not been widely examined. Method: This randomized crossover trial was conducted to evaluate VASs in free-living vs. clinic-based settings and to assess appetite response following hypocaloric whole-grain rye and refined wheat diets. Twenty-nine healthy adults with overweight or obesity continuously answered VAS questions about their perceived appetite from morning to evening. Results: No differences in whole-day VAS scores (primary outcome) between clinic-based and free-living settings were observed, whereas measures of total area under the curve (tAUC) showed increased fullness in clinic-based interventions of 7% (p < 0.008) for whole-day responses and 13% (p < 0.03) following a snack. Appetite responses for a whole day did not differ between diets whereas rye-based dinners induced 12% (p < 0.016) higher fullness and reduced hunger by 17% (p < 0.02) irrespective of setting. A reduction in hunger of 15% (p < 0.05) was also observed following rye-based vs. wheat-based lunches. Conclusion: The results suggest that the VAS is valid for evaluation of appetite responses between diets under free-living conditions. No difference in self-reported appetite over the whole day was found after whole-grain rye vs. refined wheat-based diets, but there were some suggested differences at certain postprandial periods, in individuals with overweight or obesity.
Health Literacy in Adults with Chronic Diseases in the Context of Community Health Nursing: A Scoping Review
Authors: Nock Annike Morgane , Metzing Sabine , Jürgensen Ivonne-Nadine , Petersen-Ewert Corinna
Published: May 2023

Background: Health literacy was identified as a main determinant in self-care of chronic diseases. This results in responsibilities for health professionals for daily practice. For primary care setting, special requirements arise due to the heterogeneity of communities. The objective of this scoping review was to explore and map the scope of the research material on strategies led by community health nurses to improve health literacy in (patients with) chronic diseases. This review aimed to identify gaps in the literature and existing approaches on promoting health literacy by community nurse practitioners. Methods: The following criteria were included for the research: Adults with chronic diseases, health literacy, community health nursing and primary healthcare. All types of searches for studies from 1970 to present were carried out in electronic databases and in a Google and a Google Scholar search. The search procedure is presented in a flow chart. Results: From all reviewed studies, nine records were included in the review. Findings with regard to the increase in health literacy in self-management of chronically ill patients were identified. Conclusion: Studies focusing on specific demands with regard to the role of community health nurses need to be carried out in depth.
Evaluation of Sex Differences in Preclinical Pharmacology Research: How Far Is Left to Go?
Authors: Allegra Sarah , Chiara Francesco , Di Grazia Daniela , Gaspari Marco , De Francia Silvia
Published: May 2023

Until the last quarter of the 20th century, sex was not recognized as a variable in health research, nor was it believed to be a factor that could affect health and illness. Researchers preferred studying male models for a variety of reasons, such as simplicity, lower costs, hormone confounding effects, and fear of liability from perinatal exposure in case of pregnancy. Equitable representation is imperative for determining the safety, effectiveness, and tolerance of therapeutic agents for all consumers. Decades of female models’ underrepresentation in preclinical studies has resulted in inequality in the understanding, diagnosis, and treatment of disease between the sexes. Sex bias has been highlighted as one of the contributing factors to the poor translation and replicability of preclinical research. There have been multiple calls for action, and the inclusion of sex as a biological variable is increasingly supported. However, although there has been substantial progress in the efforts to include more female models in preclinical studies, disparities today remain. In the present review, we consider the current standard practice of the preclinical research setting, why the sex bias exists, why there is the need to include female models, and what risks may arise from continuing this exclusion from experimental design.
Micro Injection Molding of Drug-Loaded Round Window Niche Implants for an Animal Model Using 3D-Printed Molds
Authors: Mau Robert , Eickner Thomas , Jüttner Gábor , Gao Ziwen , Wei Chunjiang , Fiedler Nicklas , Senz Volkmar , Lenarz Thomas , Grabow Niels , Scheper Verena , Seitz Hermann
Published: May 2023

A novel approach for the long-term medical treatment of the inner ear is the diffusion of drugs through the round window membrane from a patient-individualized, drug-eluting implant, which is inserted in the middle ear. In this study, drug-loaded (10 wt% Dexamethasone) guinea pig round window niche implants (GP-RNIs, ~1.30 mm × 0.95 mm × 0.60 mm) were manufactured with high precision via micro injection molding (µIM, Tmold = 160 °C, crosslinking time of 120 s). Each implant has a handle (~3.00 mm × 1.00 mm × 0.30 mm) that can be used to hold the implant. A medical-grade silicone elastomer was used as implant material. Molds for µIM were 3D printed from a commercially available resin (TG = 84 °C) via a high-resolution DLP process (xy resolution of 32 µm, z resolution of 10 µm, 3D printing time of about 6 h). Drug release, biocompatibility, and bioefficacy of the GP-RNIs were investigated in vitro. GP-RNIs could be successfully produced. The wear of the molds due to thermal stress was observed. However, the molds are suitable for single use in the µIM process. About 10% of the drug load (8.2 ± 0.6 µg) was released after 6 weeks (medium: isotonic saline). The implants showed high biocompatibility over 28 days (lowest cell viability ~80%). Moreover, we found anti-inflammatory effects over 28 days in a TNF-α-reduction test. These results are promising for the development of long-term drug-releasing implants for human inner ear therapy.
Optimized Chitosan-Based Nanoemulsion Improves Luteolin Release
Authors: Diedrich Camila , Zittlau Isabella C. , Khalil Najeh M. , Leontowich Adam F. G. , Freitas Rilton A. de , Badea Ildiko , Mainardes Rubiana M.
Published: May 2023

Luteolin (LUT) is a flavonoid found in several edible and medicinal plants. It is recognized for its biological activities such as antioxidant, anti-inflammatory, neuroprotective, and antitumor effects. However, the limited water solubility of LUT leads to poor absorption after oral administration. Nanoencapsulation may improve the solubility of LUT. Nanoemulsions (NE) were selected for the encapsulation of LUT due to their biodegradability, stability, and ability to control drug release. In this work, chitosan (Ch)-based NE was developed to encapsulate luteolin (NECh-LUT). A 23 factorial design was built to obtain a formulation with optimized amounts of oil, water, and surfactants. NECh-LUT showed a mean diameter of 67.5 nm, polydispersity index 0.174, zeta potential of +12.8 mV, and encapsulation efficiency of 85.49%. Transmission electron microscopy revealed spherical shape and rheological analysis verified the Newtonian behavior of NECh-LUT. SAXS technique confirmed the bimodal characteristic of NECh-LUT, while stability analysis confirmed NECh-LUT stability when stored at room temperature for up to 30 days. Finally, in vitro release studies showed LUT controlled release up to 72 h, indicating the promising potential of NECh-LUT to be used as novel therapeutic option to treat several disorders.
John Dewey’s Radical Temporalism
Authors: Colapietro Vincent
Published: May 2023

The author presents John Dewey’s mature account of temporal continuity, showing how Dewey’s position can be identified as a form of radical temporalism. Even at the most elemental level (that of subatomic particles), natural existence is for such a temporalist an irreducibly temporal affair. While he focuses primarily on Dewey’s “Time and Individuality” (1940), the author supplements his account by drawing upon Experience and Nature (1925), “Events and the Future” (1926), and to a lesser extent, other texts. In his magnum opus, Dewey draws a crucial distinction between temporal quality and temporal seriality. In an essay published the following year, he insists, contra C. D. Broad, on qualitative heterogeneity being an intrinsic trait of even the thinnest slice of the tem-poral continuum. The most elemental units of the temporal flux are neither “eternal and immu-table”, nor qualitatively homogenous. They also exhibit a from-to-through structure, with the dimensions of time being defined by these terms (pastness as from which, futurity as toward which, and presentness as through which). By relating the distinction between temporal quality and temporal seriality as well as the central claims made in “Events and the Future” to “Time and Individuality”, the author brings into clear focus the contours of Dewey’s radical temporalism.
Ketols Emerge as Potent Oxylipin Signals Regulating Diverse Physiological Processes in Plants
Authors: Berg-Falloure Katherine M. , Kolomiets Michael V.
Published: May 2023

Plants produce an array of oxylipins implicated in defense responses against various stresses, with about 600 oxylipins identified in plants to date. Most known oxylipins are the products of lipoxygenase (LOX)-mediated oxygenation of polyunsaturated fatty acids. One of the most well-characterized oxylipins produced by plants is the hormone jasmonic acid (JA); however, the function of the vast majority of oxylipins remains a mystery. One of the lesser-studied groups of oxylipins is comprised of ketols produced by the sequential action of LOX, allene oxide synthase (AOS), followed by non-enzymatic hydrolysis. For decades, ketols were mostly considered mere by-products of JA biosynthesis. Recent accumulating evidence suggests that ketols exhibit hormone-like signaling activities in the regulation of diverse physiological processes, including flowering, germination, plant–symbiont interactions, and defense against biotic and abiotic stresses. To complement multiple reviews on jasmonate and overall oxylipin biology, this review focuses specifically on advancing our understanding of ketol biosynthesis, occurrence, and proposed functions in diverse physiological processes.
Wax Composition of Serbian Dianthus spp. (Caryophyllaceae): Identification of New Metabolites and Chemotaxonomic Implications
Authors: Mladenović Marko Z. , Ristić Milenko N. , Bogdanović Andrija I. , Ristić Novica R. , Boylan Fabio , Radulović Niko S.
Published: May 2023

Although ethnopharmacologically renowned, wax constituents of Dianthus species were sporadically studied. A combination of GC-MS analysis, synthesis, and chemical transformations enabled the identification of 275 constituents of diethyl-ether washings of aerial parts and/or flowers of six Dianthus taxa (Dianthus carthusianorum, D. deltoides, D. giganteus subsp. banaticus, D. integer subsp. minutiflorus, D. petraeus, and D. superbus) and one Petrorhagia taxon (P. prolifera) from Serbia. Seventeen of these constituents (nonacosyl benzoate, additional 12 benzoates with anteiso-branched 1-alkanols, eicosyl tiglate, triacontane-14,16-dione, dotriacontane-14,16-dione, and tetratriacontane-16,18-dione) and two additional synthesized eicosyl esters (angelate and senecioate) represent completely new compounds. The structures of the tentatively identified β-ketones were confirmed by analysis of the mass fragmentation of the corresponding pyrazoles and silyl enol ethers obtained by transformations of crude extracts and extract fractions. Silylation allowed the identification of 114 additional constituents, including a completely new natural product (30-methylhentriacontan-1-ol). The results obtained by multivariate statistical analyses showed that the chemical profile of Dianthus taxa’s surface waxes is subject to both genetic and ecological factors, whereas the latter seemingly takes a more important role for the studied Dianthus samples.
Cooperative Effect of Chemical and Physical Processes for Flame Retardant Additives in Recycled ABS
Authors: Rodriguez Alicia , Herrero Manuel , Asensio Maria , Santiago-Calvo Mercedes , Guerrero Julia , Cañibano Esteban , Fernández Maria Teresa , Nuñez Karina
Published: May 2023

In the present work, the effectiveness of four non-halogenated flame retardants (FR) (aluminium trihydroxide (ATH), magnesium hydroxide (MDH), Sepiolite (SEP) and a mix of metallic oxides and hydroxides (PAVAL)) in blends with recycled acrylonitrile-butadiene-styrene (rABS) was studied in order to develop a more environmentally friendly flame-retardant composite alternative. The mechanical and thermo-mechanical properties of the obtained composites as well as their flame-retardant mechanism were evaluated by UL-94 and cone calorimetric tests. As expected, these particles modified the mechanical performance of the rABS, increasing its stiffness at the expense of reducing its toughness and impact behavior. Regarding the fire behavior, the experimentation showed that there is an important synergy between the chemical mechanism provided by MDH (decomposition into oxides and water) and the physical mechanism provided by SEP (oxygen barrier), which means that mixed composites (rABS/MDH/SEP) can be obtained with a flame behavior superior to that of the composites studied with only one type of FR. In order to find a balance between mechanical properties, composites with different amounts of SEP and MDH were evaluated. The results showed that composites with the composition rABS/MDH/SEP: 70/15/15 wt.% increase the time to ignition (TTI) by 75% and the resulting mass after ignition by more than 600%. Furthermore, they decrease the heat release rate (HRR) by 62.9%, the total smoke production (TSP) by 19.04% and the total heat release rate (THHR) by 13.77% compared to unadditivated rABS; without compromising the mechanical behavior of the original material. These results are promising and potentially represent a greener alternative for the manufacture of flame-retardant composites.
Covalent Crosslinking Cellulose/Graphene Aerogels with High Elasticity and Adsorbability for Heavy Metal Ions Adsorption
Authors: Sun Peipei , Wang Meng , Wu Tingting , Guo Longsuo , Han Wenjia
Published: May 2023

With the fast development of modern industry, heavy metal contaminant became more severe. How to remove heavy metal ions in water in a green and efficient way is a prominent problem in current environmental protection. The adsorption of cellulose aerogel as a novel heavy metal removal technology has many advantages, including abundant resources, environmental friendly, high specific surface, high porosities and without second pollution, which means it has a wide application prospect. Here, we reported a self-assembly and covalent crosslinking strategy to prepare elastic and porous cellulose aerogels using PVA and graphene and cellulose as precursor. The resulting cellulose aerogel had a low density of 12.31 mg cm−3 and excellent mechanical properties, which can recover to its initial form at 80% compressive strain. Meanwhile, the cellulose aerogel had strong adsorption capacity of Cu2+ (80.12 mg g−1), Cd2+ (102.23 mg g−1), Cr3+ (123.02 mg g−1), Co2+ (62.38 mg g−1), Zn2+ (69.55 mg g−1), and Pb2+ (57.16 mg g−1). In addition, the adsorption mechanism of the cellulose aerogel was investigated using adsorption kinetics and adsorption isotherm, and the conclusion was that the adsorption process was mainly controlled by chemisorption mechanism. Therefore, cellulose aerogel, as a kind of green adsorption material, has a very high application potential in future water treatment applications.
Sensitivity Analysis and Multi-Objective Optimization Strategy of the Curing Profile for Autoclave Processed Thick Composite Laminates
Authors: Zhang Yiben , Feng Guangshuo , Liu Bo
Published: May 2023

To mitigate the risk of manufacturing defects and improve the efficiency of the autoclave-processed thick composite component curing process, parameter sensitivity analysis and optimization of the curing profile were conducted using a finite element model, Sobol sensitivity analysis, and the multi-objective optimization method. The FE model based on the heat transfer and cure kinetics modules was developed by the user subroutine in ABAQUS and validated by experimental data. The effects of thickness, stacking sequence, and mold material on the maximum temperature (Tmax), temperature gradient (ΔT), and degree of curing (DoC) were discussed. Next, parameter sensitivity was tested to identify critical curing process parameters that have significant effects on Tmax, DoC, and curing time cycle (tcycle). A multi-objective optimization strategy was developed by combining the optimal Latin hypercube sampling, radial basis function (RBF), and non-dominated sorting genetic algorithm-II (NSGA-II) methods. The results showed that the established FE model could predict the temperature profile and DoC profile accurately. Tmax always occurred in the mid-point regardless of laminate thickness; the Tmax and ΔT increased non-linearly with the increasing laminate thickness; but the DoC was affected slightly by the laminate thickness. The stacking sequence has little influence on the Tmax, ΔT, and DoC of laminate. The mold material mainly affected the uniformity of the temperature field. The ΔT of aluminum mold was the highest, followed by copper mold and invar steel mold. Tmax and tcycle were mainly affected by the dwell temperature T2, and DoC was mainly affected by dwell time dt1 and dwell temperature T1. The multi-objective optimized curing profile could reduce the Tmax and tcycle by 2.2% and 16.1%, respectively, and maintain the maximum DoC at 0.91. This work provides guidance on the practical design of cure profiles for thick composite parts.
Enhancing the Fatigue Strength of the Weld Line in Advanced Polymer Injection Molding: Gas-Assisted Mold Temperature Control for Thermoplastic Polyurethane (TPU) Composites
Authors: Minh Pham Son , Uyen Tran Minh The , Do Thanh Trung , Nguyen Van-Thuc , Nguyen Van Thanh Tien
Published: May 2023

This study presents an innovative approach to enhancing weld line strength in advanced polymer injection molding through applying gas-assisted mold temperature control, significantly increasing mold temperature beyond typical values observed in conventional processes. We investigate the effects of various heating times and frequencies on the fatigue strength of Polypropylene (PP) samples and the tensile strength of Acrylonitrile Butadiene Styrene (ABS) composite samples at different Thermoplastic Polyurethane (TPU) percentages and heating times. Using gas-assisted mold heating, mold temperatures exceeding 210 °C are achieved, which represents a significant advancement compared to the standard mold temperatures of less than 100 °C. As a result, the fatigue strength of the PP sample with mold heating at 15 s shows a remarkable increase of up to 5.4 times at 5 Hz compared to the sample without mold temperature control. Moreover, ABS/TPU blends with 15 wt.% TPU exhibit the highest ultimate tensile strength (UTS) value of 36.8 MPa, while blends with 30 wt.% TPU have the lowest UTS value of 21.3 MPa. This advancement demonstrates the potential for improved welding line bonding and fatigue strength in manufacturing. Our findings reveal that increasing the mold temperature before injection results in higher fatigue strength in the weld line, with the TPU percentage having a more significant influence on the mechanical properties of ABS/TPU blends than heating time. The results of this study contribute to a deeper understanding of advanced polymer injection molding and offer valuable insights for process optimization.
Preparation of Microencapsulated Phase Change Materials from Sulfonated Graphene Stabilized Pickering Emulsion
Authors: Li Weiping , Mei Dajiang , Wang Jihu , Wu Hui , Wen Shaoguo
Published: May 2023

Microencapsulated phase change materials (MCPCM) as a green energy storage material not only prevent leakage of phase change materials but also increase the heat transfer area of phase change materials. Extensive previous work has shown that the performance of MCPCM depends on the shell material and MCPCM with polymers, as the shell material suffers from low mechanical strength and low thermal conductivity. In this study, a novel MCPCM with hybrid shells of melamine-urea-formaldehyde (MUF) and sulfonated graphene (SG) was prepared by in situ polymerization using SG-stabilized Pickering emulsion as a template. The effects of SG content and core/shell ratio on the morphology, thermal properties, leak-proof properties, and mechanical strength of the MCPCM were investigated. The results showed that the incorporation of SG into the shell of MUF effectively improved the contact angles, leak-proof performance, and mechanical strength of the MCPCM. Specifically, the contact angles of MCPCM-3SG were reduced by 26°, the leakage rate was reduced by 80.7%, and the breakage rate after high-speed centrifugation was reduced by 63.6% compared to MCPCM without SG. These findings suggest that the MCPCM with MUF/SG hybrid shells prepared in this study has great potential for application in thermal energy storage and management systems.
Optimization of the Performances of Palm Oil Mill Effluent (POME)-Based Biogas Plants Using Comparative Analysis and Response Surface Methodology
Authors: Yong Gloria Tung Xin , Chan Yi Jing , Lau Phei Li , Ethiraj Baranitharan , Ghfar Ayman A. , Mohammed Abdallah A. A. , Shahid Muhammad Kashif , Lim Jun Wei
Published: May 2023

The rapid increase in demand for renewable energy has led to a need for more efficient and effective ways to produce biogas from palm oil mill effluent (POME), which is rich in biological and chemical oxygen demand (BOD and COD). Despite its potential as a source of biogas, POME is not always effectively utilized in biogas production due to a lack of optimization of the treatment process. This study aims to address this issue by identifying the critical parameters affecting biogas production from POME and optimizing the process for maximum biogas yield and COD removal. This study employed comparative analysis and response surface methodology to optimize the performance of palm oil mill effluent (POME)-based biogas plants in Malaysia. Historical data from three commercial POME-based biogas plants in Malaysia were analyzed to identify the most critical parameters for biogas yield and COD removal. Response surface methodology, using Box–Behnken design and Design-Expert software, was then used to optimize these parameters. Sensitivity analysis was performed to interpret the impact of parameters on biogas production, with Organic Loading Rate (OLR) found to be the most critical factor for methane yield. The results showed that the optimum conditions for maximum methane production were OLR of 1.23 kg/m3·day, inlet Total Solids (TS) of 46,370 mg/L, pH of 4.5, and temperature of 45.4 °C, resulting in a 39.6% increase in methane yield (0.335 m3 CH4/kgCODremoved) and a 1.1% increase in COD removal (93.4%).
A Possible Explicit Equation Fitting Method for the Gaseous Heat Capacity Near the Critical Point Based on Density and Temperature
Authors: Li Mukun , Wang Gang , Sun Lulu , Cao Xiaoqiang , Ni Hongjian
Published: May 2023

CO2 is a potential fluid for absorbing and accumulating thermal energy; an accurate and fast calculation method for the heat capacity is essential for the study of the flow state near the critical point. However, the calculation of the heat capacity near the critical point by the equations suggested by NIST can easily be divergent, such as for CO2, nitrogen, methane, etc. Therefore, an explicit fitting equation was studied. The fitting equation, which used density and temperature as variables and contained three constants, was derived from the nature of heat capacity change (molecular kinetic energy and potential energy). Based on the heat capacity data of the NIST WebBook, the heat capacity of CO2 is taken as the example for the equation deduction and parameter fitting. The three constants were defined in order by Origin fitting software. By this new approach, it is found that the heat capacity at the critical point is below 1% deviant from that of the NIST WebBook. Moreover, the heat capacities that are difficult to be calculated in the NIST WebBook are well calculated. The study shows that the fitting equation is efficient for the prediction of heat capacity of gases near the critical point.
Study on Adsorption and Photocatalytic Properties of Zinc Ferrite
Authors: Yang Jinlin , Huo Xingnan , Li Zongyu , Li Hengjun , Wang Teng , Ma Shaojian
Published: May 2023

In this study, methyl orange, methylene blue, and amido black 10B were removed as target dyes using purified, synthetic, and purchased zinc ferrite as adsorbents and photocatalysts. The highest removal rates of amido black 10B by these adsorbents ranged from 81.62% to 88.33%. The removal rate of methyl orange was approximately 1%, and the removal rate of methylene blue was approximately 2%. Hence, an investigation was conducted to elucidate the factors that influence the removal efficacy of purified zinc ferrite on amido black 10B. Titanium dioxide prepared at different calcination temperatures was unsuccessful in removing amido black 10B, but the physical mixing of titanium dioxide prepared at suitable calcination temperatures with purified zinc ferrite had a positive effect on amido black 10B removal. Since zinc ferrite could not be used as an adsorbent to remove methyl orange and methylene blue, the photocatalytic degradation properties of zinc ferrite and its influencing factors were studied. The optimal conditions for the photocatalytic degradation of methylene blue and methyl orange by zinc ferrite are as follows: a zinc ferrite catalyst dosage of 0.15 g, an initial solution concentration of 20 mg/L, and a pH of 6.0. The dosage of the zinc ferrite/titanium dioxide composite catalyst is 0.15 g, the initial solution concentration is 20 mg/L, and the pH is 6.5.
Development of Conceptual Reasoning versus Understanding of Children’s Theory of Mind and Extraordinary (Supernatural) Minds during Middle Childhood
Authors: Rydz Elżbieta , Gut Arkadiusz , Pietryga Anna , Wróblewski Zbigniew
Published: May 2023

It is still not known how a person acquires the ability to think about extraordinary minds. This study examined the point at which a significant distinction appears, the conceptual differentiation of the ordinary mind from the extraordinary mind. Additionally, it examined whether this distance is related to a certain type of conceptual knowledge and understanding of religious concepts. The study involved 117 children from Poland within the age range of 3 to 7 years old (56% girls; 44% boys). The following methods were used: The Deceptive Box Task, The Conceptual reasoning scale from the IDS-P, and the Short test of understanding religious concepts. The obtained results are closer to one of the hypotheses discussed in this area—the anthropomorphism hypothesis, which assumes that after gaining competence in understanding ordinary minds, children begin to build and understand the competencies of extraordinary minds.
Religion at School in Secular Europe
Authors: Uriarte Luzio , Rodríguez Lidia
Published: May 2023

It is widely accepted that Europe is characterised by a secularised society and states marked by laicism (laïcité). The article analyses how this European secularity observes religious education, highlighting the fact that it does not have a single model. The diversity of interpretations of the term “secularity” is not unrelated to the fact that there is a plurality of approaches to the teaching (or non-teaching) of religion within European education systems. The authors of the article opt for Taylor’s approach of defining secularity not by its relation to religion, but by the ends it desires to achieve. Within this framework, the article describes the plurality of models of teaching religion in education systems and how these models articulate the values that secularity seeks to achieve. The analysis takes into account both the guidelines and recommendations of European institutions and the policies implemented by states.
A New Region-Based Minimal Path Selection Algorithm for Crack Detection and Ground Truth Labeling Exploiting Gabor Filters
Authors: de León Gonzalo , Fiorentini Nicholas , Leandri Pietro , Losa Massimo
Published: May 2023

Cracks are fractures or breaks that occur in materials such as concrete, metals, rocks, and other solids. Various methods are used to detect and monitor cracks; among many of them, image-based methodologies allow fast identification of the distress and easy quantification of the percentage of cracks in the scene. Two main categories can be identified: classical and deep learning approaches. In the last decade, the tendency has moved towards the use of the latter. Even though they have proven their outstanding predicting performance, they suffer some drawbacks: a “black-box” nature leaves the user blind and without the possibility of modifying any parameters, a huge amount of labeled data is generally needed, a process that requires expert judgment is always required, and, finally, they tend to be time-consuming. Accordingly, the present study details the methodology for a new algorithm for crack segmentation based on the theory of minimal path selection combined with a region-based approach obtained through the segmentation of texture features extracted using Gabor filters. A pre-processing step is described, enabling the equalization of brightness and shadows, which results in better detection of local minima. These local minimal are constrained by a minimum distance between adjacent points, enabling a better coverage of the cracks. Afterward, a region-based segmentation technique is introduced to determine two areas that are used to determine threshold values used for rejection. This step is critical to generalize the algorithm to images presenting close-up scenes or wide cracks. Finally, a geometrical thresholding step is presented, allowing the exclusion of rounded areas and small isolated cracks. The results showed a very competitive F1-score (0.839), close to state-of-the-art values achieved with deep learning techniques. The main advantage of this approach is the transparency of the workflow, contrary to what happens with deep learning frameworks. In the proposed approach, no prior information is required; however, the statistical parameters may have to be adjusted to the particular case and requirements of the situation. The proposed algorithm results in a useful tool for researchers and practitioners needing to validate their results against some reference or needing labeled data for their models. Moreover, the current study could establish the grounds to standardize the procedure for crack segmentation with a lower human bias and faster results. The direct application of the methodology to images obtained with any low-cost sensor makes the proposed algorithm an operational support tool for authorities needing crack detection systems in order to monitor and evaluate the current state of the infrastructures, such as roads, tunnels, or bridges.
Research on the Monitoring Ability of Fengyun-Based Quantitative Precipitation Estimates for Capturing Heavy Precipitation: A Case Study of the “7·20” Rainstorm in Henan Province, China
Authors: Wu Hao , Yong Bin , Shen Zhehui
Published: May 2023

One of the important tasks of the Chinese geostationary and meteorological satellite Fengyun-2 (FY2) series is to provide quantitative precipitation estimates (QPE) with high spatiotemporal resolutions for East Asia. To analyze the monitoring capabilities of FY2-based QPEs in extreme rainfall events, this study comprehensively evaluated and compared the performances of FY-2G and FY-2H QPEs for the “7.20” rainstorm in Henan province, China from 17 July 2021 to 22 July 2021. Three continuous metrics and three categorical metrics were adopted to assess the accuracies of FY-2G and FY-2H QPEs, referenced by gauge observations from 116 meteorological stations. The results show that the FY-2G QPE has lower BIAS (−9.64% for FY-2G, −46.22% for FY-2H) and RMSE (5.83 mm/h for FY-2G, 8.4 mm/h for FY-2H) and higher CC (0.57 for FY-2G, 0.24 for FY-2H) than FY-2H QPE in this rainstorm event. Moreover, the FY-2G QPE is not only more consistent with the ground reference with respect to the rainfall amount, but also has higher detecting capability in the “7.20” rainstorm event when compared with the FY-2H QPE. The FY-2G QPE presented a higher capability to correctly capture the precipitation event for the “7.20” rainstorm because of higher POD (probability of detection) and CSI (critical success index) relative to FY-2H QPE, especially in complex topography. From the spatial distribution of precipitation amount, the FY-2G QPE captured the rainstorm center of extreme precipitation more accurately relative to the latest FY-2H product. On the other hand, the previous generation of FY-2G QPE was closer to the continuous rainfall process and precipitation duration with ground observations than the latest FY-2H QPE. Therefore, the precipitation retrieval algorithm of FY-2H QPE still had room to improve. It is necessary to introduce error correction algorithms, especially in complex topography for rainstorm events.
Spatial Probability Characteristics of Waves Generated by Polar Lows in Nordic and Barents Seas
Authors: Yurovskaya Maria , Kudryavtsev Vladimir , Chapron Bertrand
Published: May 2023

Polar lows (PLs) are mesoscale, up to 1000 km, rather short lifetime (less than 15–30 h) cyclonic atmospheric systems formed in polar latitudes and associated with cold outbreak events. Strong winds, higher than 15 m/s, can then generate high surface waves which may pose danger to marine and coastal infrastructures. To investigate the probability of high waves generated by PLs in the Nordic and Barents Seas, analysis can be performed using available PL statistical distributions obtained from satellite passive microwave data, MODIS infrared imagery and ASCAT scatterometer data. Classical self-similar laws for wind waves development based on the extended duration concept are used to obtain first-guess estimates of significant wave height and the wavelength of waves generated by PL. All possible combinations of PL parameters (maximum wind speed, lifetime, diameter, translation velocity and direction of propagation) are considered to obtain the occurrence of waves exceeding specified levels, ranging from 2 to 15 m for significant wave height and from 100 to 500 m for wavelength. Particularly, PL-generated waves higher than 4 m occur up to 6 times a year, higher than 8 m occur up to 2–3 times a year, higher than 10 m occur up to once a year, the probability of 12 m waves is one event in several years and 15 m SWHs occur less than once in a decade. The area most affected by strong waves from PLs is the near shore zone around the Scandinavian peninsula, northward from the North Cape. The relative contribution of PLs in the formation of the waves field in the Nordic and Barents Seas is discussed.