bluuebunny/crossref_metadata_2025 huggingface dataset:
Fibrinogen-like protein 2 promotes tumor immune suppression by regulating cholesterol metabolism in myeloid-derived suppressor cells
Authors: Wu Lei , Liu Xudong , Lei Juan , Zhang Nan , Zhao Huakan , Zhang Jiangang , Deng Huan , Li Yongsheng
Published: December 2023

Background

Myeloid-derived suppressor cells (MDSCs) are crucial mediators of tumor-associated immune suppression. Targeting the accumulation and activation of MDSCs has been recognized as a promising approach to enhance the effectiveness of immunotherapies for different types of cancer.

Methods

The MC38 and B16 tumor-bearing mouse models were established to investigate the role of Fgl2 during tumor progression. Fgl2 and FcγRIIB-deficient mice, adoptive cell transfer, RNA-sequencing and flow cytometry analysis were used to assess the role of Fgl2 on immunosuppressive activity and differentiation of MDSCs.

Results

Here, we show that fibrinogen-like protein 2 (Fgl2) regulates the differentiation and immunosuppressive functions of MDSCs. The absence of Fgl2 leads to an increase in antitumor CD8+T-cell responses and a decrease in granulocytic MDSC accumulation. The regulation mechanism involves Fgl2 modulating cholesterol metabolism, which promotes the accumulation of MDSCs and immunosuppression through the production of reactive oxygen species and activation of XBP1 signaling. Inhibition of Fgl2 or cholesterol metabolism in MDSCs reduces their immunosuppressive activity and enhances differentiation. Targeting Fgl2 could potentially enhance the therapeutic efficacy of anti-PD-1 antibody in immunotherapy.

Conclusion

These results suggest that Fgl2 plays a role in promoting immune suppression by modulating cholesterol metabolism and targeting Fgl2 combined with PD-1 checkpoint blockade provides a promising therapeutic strategy for antitumor therapy.
Model for classification of heart failure severity in patients with hypertrophic cardiomyopathy using a deep neural network algorithm with a 12-lead electrocardiogram
Authors: Togo Sanshiro , Sugiura Yuki , Suzuki Sayumi , Ohno Kazuto , Akita Keitaro , Suwa Kenichiro , Shibata Shin-ichi , Kimura Michio , Maekawa Yuichiro
Published: December 2023

Objectives

In hypertrophic cardiomyopathy (HCM), specific ECG abnormalities are observed. Therefore, ECG is a valuable screening tool. Although several studies have reported on estimating the risk of developing fatal arrhythmias from ECG findings, the use of ECG to identify the severity of heart failure (HF) by applying deep learning (DL) methods has not been established.

Methods

We assessed whether data-driven machine-learning methods could effectively identify the severity of HF in patients with HCM. A residual neural network-based model was developed using 12-lead ECG data from 218 patients with HCM and 245 patients with non-HCM, categorised them into two (mild-to-moderate and severe) or three (mild, moderate and severe) severities of HF. These severities were defined according to the New York Heart Association functional class and levels of the N-terminal prohormone of brain natriuretic peptide. In addition, the patients were divided into groups according to Kansas City Cardiomyopathy Questionnaire (KCCQ)-12. A transfer learning method was applied to resolve the issue of the low number of target samples. The model was trained in advance using PTB-XL, which is an open ECG dataset.

Results

The model trained with our dataset achieved a weighted average F1 score of 0.745 and precision of 0.750 for the mild-to-moderate class samples. Similar results were obtained for grouping based on KCCQ-12. Through data analyses using the Guided Gradient Weighted-Class Activation Map and Integrated Gradients, QRS waves were intensively highlighted among true-positive mild-to-moderate class cases, while the highlighted part was highly variable among true-positive severe class cases.

Conclusions

We developed a model for classifying HF severity in patients with HCM using a deep neural network algorithm with 12-lead ECG data. Our findings suggest that applications of this DL algorithm for using 12-lead ECG data may be useful to classify the HF status in patients with HCM.
External validation of novel clinical likelihood models to predict obstructive coronary artery disease and prognosis
Authors: Rasmussen Laust Dupont , Williams Michelle Claire , Newby David E , Dahl Jonathan Nørtoft , Schmidt Samuel Emil , Bøttcher Morten , Winther Simon
Published: December 2023

Objectives

The risk factor-weighted and coronary artery calcium score-weighted clinical likelihood (RF-CL and CACS-CL, respectively) models improve discrimination of patients with suspected obstructive coronary artery disease (CAD). However, external validation is warranted.

Compared to the 2019 European Society of Cardiology pretest probability (ESC-PTP) model, the aims were (1) to validate the RF-CL and CACS-CL models for identification of obstructive CAD and revascularisation, and (2) to investigate prognosis by CL thresholds.

Methods

Stable de novo chest pain patients (n=1585) undergoing coronary CT angiography (CTA) were investigated. Obstructive CAD was defined as >70% diameter stenosis in a major epicardial vessel on CTA. Decision of revascularisation within 120 days was based on onsite judgement. The endpoint was non-fatal myocardial infarction or cardiovascular death. The ESC-PTP was calculated based on age, sex and symptom typicality, the RF-CL additionally included number of risk factors, and the CACS-CL incorporated CACS to the RF-CL.

Results

Obstructive CAD was present in 386/1585 (24.4%) patients, and 91/1585 (5.7%) patients underwent revascularisation. Both the RF-CL and CACS-CL classified more patients to very-low CL (<5%) of obstructive CAD compared with the ESC-PTP model (41.4% and 52.2% vs 19.2%, p<0.001). In very-low CL patients, obstructive CAD and revascularisation prevalences (≤6% and <1%) remained similar combined with low event risk during 5.0 years follow-up.

Conclusion

In an external validation cohort, the novel RF-CL and CACS-CL models improve categorisation to a very-low CL group with preserved prevalences of obstructive CAD, revascularisation and favourable prognosis.
Hepatitis B vaccination associated with low response in patients with rheumatic diseases treated with biologics
Authors: Romão Vasco C , Ávila-Ribeiro Pedro , Gonçalves Maria João , Cruz-Machado Rita , Guerreiro André Bento , Teixeira Vítor , Valido Ana , Silva-Dinis Joana , Vieira-Sousa Elsa , Saavedra Maria João , Sacadura-Leite Ema , Marinho Rui Tato , Fonseca João Eurico
Published: December 2023

Background

Hepatitis B virus (HBV) vaccination is recommended for non-immunised patients with rheumatic diseases starting biological disease-modifying antirheumatic drugs (bDMARDs). There is some evidence that HBV vaccination is effective in patients under conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs), but it is currently unclear whether this also applies to bDMARDs.

Objectives

To assess the efficacy and safety of HBV vaccination in patients with inflammatory arthritides treated with bDMARDs.

Methods

A prospective cohort with inflammatory arthritides treated with bDMARDs, negative for anti-HBs and anti-HBc and never vaccinated for HBV was recruited. Engerix B was administered at 0, 1 and 6 months and anti-HBs was reassessed ≥1 month after last dose. Response was defined as anti-HBs≥10 IU/L and compared against vaccinated healthy controls. Disease flare, serious adverse events and immune-related disorders not previously present were recorded.

Results

62 patients, most treated with TNF inhibitors (TNFi), and 38 controls were recruited. Most patients were taking csDMARDs (67.7%) and were in remission/low disease activity (59.4%). Only 20/62 patients (32.3%) had a positive response to vaccination, in comparison to 36/38 age-matched controls (94.7%, p<0.001). Response was seen in 19/51 patients treated with TNFi (37.3%) and in 1/11 (9.1%) patients treated with non-TNFi (p=0.07), including 1/6 treated with tocilizumab (16.7%). Among TNFi, response rates ranged from 4/22 (18.2%) for infliximab to 8/14 (57.1%) for etanercept. No relevant safety issues were identified.

Conclusions

HBV vaccination response in patients with rheumatic diseases treated with bDMARDs was poorer than expected. Our data reinforce the recommendation for vaccination prior to starting bDMARDs.
Multiparametric cytotoxicity profiling reveals cell-line and ligand-dependent toxicity for pegylated gold nanoparticles (AuNP-PEG)
Authors: Cahill Hannah F. , Scott Bryn S. , Peter Oni Olaiya , Stapleton Grace V.L. , MacCormack Tyson J. , Meli M-Vicki , Rourke Jillian L.
Published: December 2023

The highly tunable surface chemistry of gold nanoparticles (AuNPs) makes them ideal candidates for cancer treatments. Modification of AuNP surface chemistry creates linkage points for different surface coatings whose chemical structure regulates AuNP interactions with cells and thus plays a key role in AuNP cytotoxicity. This study looked at AuNPs functionalized with three polyethylene glycol (PEG) coatings, differing in end group functionality: PEG methyl terminated thiol (PEGCH3), PEG amine terminated thiol (PEGNH2), and PEG carboxylic acid terminated thiol (PEGCOOH). Cytotoxic effects were compared across three cell lines: human embryonic kidney (HEK293T/17), prostate cancer (PC-3), and ovarian cancer (SKOV3). Biochemical assays measured the effect AuNPs elicit on the ability of single cells to form colonies, metabolize thiazolyl blue tetrazolium bromide (MTT), or produce reactive oxygen species (ROS) using 2′,7′-dichlorofluorescein. Overall, AuNP-PEG particles were minimally toxic. HEK293T/17 colony formation was significantly decreased with all but PEGCOOH particle types, and PEGNH2 treatments significantly decreased colony formation for all three tested cell lines. ROS production was significantly increased when treated with 100 µg mL−1 AuNP PEGNH2 in all three cell lines, with PEGCH3 also showing increased ROS in PC-3 cells. PEGCH3 reduced metabolic function (MTT metabolism) in only SKOV3 cells, while PEGCOOH was toxic to HEK293T/17 cells at 100 µg mL−1. These results suggest that differing end group chemistry leads to modest cytotoxic profiles for each AuNP that are cell line and coating dependent. Elucidation of AuNP mechanisms of toxicity is a critical step in the evaluation of the future therapeutic potential for these particles.
Northern Svalbard Composite Tectono-Sedimentary Element
Authors: Smelror Morten , Olaussen Snorre , Dumais Marie-Andrée , Grundvåg Sten-Andreas , Abay Tesfamariam Berhane
Published: December 2023

The Northern Svalbard Composite Tectono-Sedimentary Element (CTSE) comprises Proterozoic, Early Paleozoic and Devonian sedimentary rocks preserved in northern Svalbard and on the adjacent shelf margin between complexes of metamorphic and crystalline basement rocks. The Northern Svalbard CTSE covers four main tectono-sedimentary elements: Tonian synrift, Neoproterozoic–Cambrian post-rift, Ordovician passive margin and late Silurian?/Devonian synextensional basins. The oldest documented sedimentary strata are greywacke and shale deposited after the Greenvillian Orogeny and assumed to be younger than 980–960 Ma. The present CTSE further includes Cambrian–Ordovician sedimentary rocks in Ny-Friesland and Nordaustlandet, while the dominant part of the CTSE are continental Old Red Sandstone sediments of the late Silurian?/Early Devonian Red Bay and Siktefjellet groups and the Early–Late Devonian Andreé Land Group onshore northern Spitsbergen. Locally, the Cambrian–Ordovician formations contain petroleum source rocks with moderate total organic carbon contents and relatively high hydrogen index values, suggesting a good potential for oil generation. There are possible reservoirs, seals and traps in some of the basins but the CTSE generally holds a very limited potential as a petroleum province, particularly as the region is under strict environmental protection.
Women at Work: Pathways from Gender Stereotypes to Gender Bias and Discrimination
Authors: Heilman Madeline E. , Caleo Suzette , Manzi Francesca
Published: December 2023

Despite important advances, gender-based discrimination continues to hinder women's career progress. This review examines the role that gender stereotypes play in promoting gender bias and discrimination. After reviewing what is known about the content of gender stereotypes and examining both their descriptive and prescriptive aspects, we discuss two pathways through which stereotypes result in discrepant work outcomes for women and men. First, we consider how the characterization of women as communal but not agentic conflicts with the perceived demands of many male gender-typed jobs and fields, thus promoting perceptions of women's lack of competence in those areas. Second, we consider how norms about how women should and should not behave cause women to incur penalties when they exhibit counter-stereotypical attributes and behaviors at work. Our review further focuses on the conditions that foster or undercut gender bias and discrimination and uses this knowledge as a foundation for proposing strategies to promote more egalitarian organizational processes.
Image-Based Arabic Sign Language Recognition System Using Transfer Deep Learning Models
Authors: Bani Baker Qanita , Alqudah Nour , Alsmadi Tibra , Awawdeh Rasha
Published: December 2023

Sign language is a unique communication tool helping to bridge the gap between people with hearing impairments and the general public. It holds paramount importance for various communities, as it allows individuals with hearing difficulties to communicate effectively. In sign languages, there are numerous signs, each characterized by differences in hand shapes, hand positions, motions, facial expressions, and body parts used to convey specific meanings. The complexity of visual sign language recognition poses a significant challenge in the computer vision research area. This study presents an Arabic Sign Language recognition (ArSL) system that utilizes convolutional neural networks (CNNs) and several transfer learning models to automatically and accurately identify Arabic Sign Language characters. The dataset used for this study comprises 54,049 images of ArSL letters. The results of this research indicate that InceptionV3 outperformed other pretrained models, achieving a remarkable 100% accuracy score and a 0.00 loss score without overfitting. These impressive performance measures highlight the distinct capabilities of InceptionV3 in recognizing Arabic characters and underscore its robustness against overfitting. This enhances its potential for future research in the field of Arabic Sign Language recognition.
Identifying Key Node with Motif‐Based PageRank on Acupoint‐Disease Network
Authors: Yu Xuelong , Liu Xiao , Luo Li , Zhao Hai
Published: December 2023

Existing research combines acupuncture theory with network science and proposes a new paradigm for the study of acupoint selection patterns—a key acupoint mining algorithm based on acupoint networks. However, the basic idea of this study for finding key acupoints is based on binary acupoint synergy relationships, which ignores the higher‐order synergy among multiple acupoints and does not truly reflect the implicit patterns of each acupoint among meridian systems. Moreover, the mining results assessment method, which this new paradigm involves, does not have wide applicability and universality. In this paper, with the introduction of higher‐order interactions between multiple acupoints, a high‐specificity key acupoint mining algorithm based on 3‐node motif is proposed in the acupoint‐disease network (ADN). In response to the narrow applicability of the new research paradigm involving the evaluation of algorithms’ measures, new and widely applicable and universal evaluation criteria are introduced in terms of resolution, network loss, and accuracy, respectively. Based on the principles of acupoint selection involved in acupuncture clinics in Chinese medicine, the acupoints involved in the data were divided into a total of 19 regions according to their distribution characteristics. From these 19 regions, we selected the key acupoints that have a large impact on the global network. Finally, we compared this algorithm with five other acupoint importance assessment algorithms in terms of resolution, network loss, and accuracy, respectively. The comprehensive results show that the algorithm identifies key acupoints with an accuracy of 63%, which is 14% to 21% higher than other existing methods. The key acupoints identified by the algorithm have a significant disruptive effect on the connectivity of the network, indicating that the key acupoints are at the core of the acupoint‐disease network topology. They have a significant propagation influence on other acupoints, which means that the key acupoints have high‐synergistic cooperation with other acupoints. Meanwhile, the stability and specificity of the algorithm ensure the reliability of the key acupoints. We believe that the key acupoints identified by the algorithm can be used as core acupoints from the perspective of network topology and high synergy of other acupoints, respectively, and help researchers explore targeted and high‐impact combinations of acupoints to optimize existing acupuncture prescriptions under condition constraints.
Emerging Technologies to Promote Fans Interaction in Football Events: A Systematic Review
Authors: Martins Francisco , França Cíntia , Paixão Pedro , Martinho Diogo V. , Campos Pedro , Gouveia Bruna , Lopes Helder , Ihle Andreas , Marques Eduardo , Gouveia Élvio Rúbio
Published: December 2023

As the digital revolution continues to take hold in contemporary society, new technology and communications networks have provided football with new possibilities and prospects for expansion. This study provides an assessment of the published research regarding innovative digital tools designed to increase the interactivity of fans when watching a football match, regardless of whether they do it at home or at the stadium. A systematic review of the literature was performed, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. The search was conducted in the PubMed, Web of Science, and Scopus databases. The final sample included eleven studies for analysis. Overall, the investigations that structure this review seem to be in the early stages of their development, with eight of them making tests with the target audience and the other three still in protocol development processes. Six studies concluded that fans had positive and exciting experiences using mobile applications or interactive systems. Two studies showed promising results in the area of football fans’ health, and only one study showed some difficulties for fans using an ad hoc network in the stadium. Adding personal information, fan interaction systems, specific information about the players and the teams’ tactical strategies, and interactive fan voting seem to be important elements for designing a successful interactive tool that contributes to increasing fans’ enthusiasm during football matches.
Renal Embolism Associated with Foramen Ovale Coexisting Acute Pulmonary Embolism
Authors: He Yanling , Xiao Yi , Chen Yanping , Li Zhidong
Published: December 2023

We report a singular case of renal embolism in a hitherto healthy 46-year-old female. The patient initially presented with symptoms of exertional distress and chest discomfort. Following an extensive diagnostic workup, she was subsequently diagnosed with acute pulmonary embolism. On the day succeeding her admission, the patient manifested sustained abdominal discomfort. Abdominal computed tomography angiography (CTA) subsequently revealed the presence of renal artery embolisms and infarctions. Concurrently, an echocardiographic evaluation disclosed a patent foramen ovale (PFO) and pulmonary hypertension. In this specific case, we hypothesize that the embolic event traversed through the PFO, ultimately localizing in the renal artery and culminating in renal embolism.
Challenges and Possible Solutions of Implementing 5G Mobile Networks in Bangladesh
Authors: Hossain Md. Najmul , Al-Mamun Hasan , Islam Muhammad Shafiqul , Paul Liton Chandra , Rahim Md. Abdur , Islam Md. Matiqul , Islam Md. Ashraful , Rahman Md. Arifour
Published: December 2023

Recently, fifth-generation (5G) mobile connectivity has been launched in Bangladesh on a trial-run basis. 5G is a super-speed mobile network that is much faster than the existing fourth-generation (4G) technology. It is excruciatingly hard to deploy a fully functioning 5G in any country regardless of its available resources and technological advancements because of some apparent technological complexity and limitations. In addition, when deploying this technology in developing countries such as Bangladesh, the costs come into play. To cope with the world’s advancement in science and technology, Bangladesh is planning to implement 5G covering the whole country. In this paper, we present the major challenges in implementing a wide area 5G network in Bangladesh and find some possible solutions. This research work has also tried to get a clear picture of the service quality of the existing 4G cellular communication by analyzing some of the mobile operators’ download speeds over 24 hours. In addition, this paper presents the current comparison of Internet facilities in Bangladesh with those of other countries across the globe. To the best of our knowledge, there is no publicly available study that has focused on the deployment of the 5G network in Bangladesh after assessing the current state of the cellular network. Therefore, this study could serve as a guiding resource, providing valuable information for decision-making.
Assessment of Selected Physicochemical Properties of Soils under Different Land Uses and Topographic Positions at Gola Wachu Subwatershed, Eastern Ethiopia
Authors: Ibrahim Araba Jemal , Bedadi Bobe , Feyissa Samuel
Published: December 2023

Understanding the influence of land use types and topographic positions on soil physical and chemical properties is vital for sustainable soil management. Therefore, this study was initiated to assess the selected physicochemical properties of soils under different land uses and topographic positions in the subwatershed. The subwatershed area was divided into three land use types (cultivated, grazing, and fallow) and topographic positions (lower, middle, and upper). A total of 27 composite soil samples were collected from (0–20 cm) depth for analysis. All analyzed selected soil physicochemical properties were significantly different by using the least significance difference (LSD) test (

P
<
0.05

) for each type of land use, except for soil texture, C/N, and percent base saturation (PBS). The soil textural classes of all land-use types at each topographic position were clay loam. Overall, the results indicate that most of the selected soil physicochemical properties were lower in soils of cultivated land at each topographic position, signifying that management of soil fertility is required to make agriculture sustainable in subwatershed.
Supplementary Fig 8 from Longitudinal Natural History Study of Children and Adults with Rare Solid Tumors: Initial Results for First 200 Participants
Authors: Ahmed Shadin , Wedekind Mary Frances , Del Rivero Jaydira , Raygada Margarita , Lockridge Robin , Glod John W. , Flowers Crystal , Thomas BJ , Bernstein Donna B. , Kapustina Oxana B. , Jain Ashish , Miettinen Markku , Raffeld Mark , Xi Liqiang , Tyagi Manoj , Kim Jung , Aldape Kenneth , Malayeri Ashkan A. , Kaplan Rosandra N. , Allen Taryn , Vivelo Christina A. , Sandler Abby B. , Widemann Brigitte C. , Reilly Karlyne M.
Published: December 2023

Example of social and environmental characteristics of the NHRST cohort.
Supplementary Fig 11 from Longitudinal Natural History Study of Children and Adults with Rare Solid Tumors: Initial Results for First 200 Participants
Authors: Ahmed Shadin , Wedekind Mary Frances , Del Rivero Jaydira , Raygada Margarita , Lockridge Robin , Glod John W. , Flowers Crystal , Thomas BJ , Bernstein Donna B. , Kapustina Oxana B. , Jain Ashish , Miettinen Markku , Raffeld Mark , Xi Liqiang , Tyagi Manoj , Kim Jung , Aldape Kenneth , Malayeri Ashkan A. , Kaplan Rosandra N. , Allen Taryn , Vivelo Christina A. , Sandler Abby B. , Widemann Brigitte C. , Reilly Karlyne M.
Published: December 2023

Anxiety and depression over time.
FIGURE 3 from Longitudinal Natural History Study of Children and Adults with Rare Solid Tumors: Initial Results for First 200 Participants
Authors: Ahmed Shadin , Wedekind Mary Frances , Del Rivero Jaydira , Raygada Margarita , Lockridge Robin , Glod John W. , Flowers Crystal , Thomas BJ , Bernstein Donna B. , Kapustina Oxana B. , Jain Ashish , Miettinen Markku , Raffeld Mark , Xi Liqiang , Tyagi Manoj , Kim Jung , Aldape Kenneth , Malayeri Ashkan A. , Kaplan Rosandra N. , Allen Taryn , Vivelo Christina A. , Sandler Abby B. , Widemann Brigitte C. , Reilly Karlyne M.
Published: December 2023

Imaging and histology for 3 highlighted patients. A, Axial CT image of the abdomen showing a mass in the descending colon (arrow) in a 15-year-old male diagnosed with poorly differentiated adenocarcinoma. B, Histology shows high dysplasia and stromal microinvasion. C, MRI of the lumbar spine in a 36-year-old female diagnosed with malignant melanotic schwannoma shows oval-shaped mass in left neural foramen of L3-L4 with avid enhancement on sagittal T1-weighted fat-suppressed image (arrow). Histology (D) shows pigmented spindle and epithelioid cells. E, MRI displays two left supraclavicular masses on T1-weighted image in a 75-year-old male with metastatic poorly differentiated carcinoma of unknown primary in the neck. F, Histology shows epithelioid tumor cells. Scale bar = 100 µm and is the same for B, D, and F.
Role of Presurgical Gut Microbial Diversity in Roux-en-Y Gastric Bypass Weight-Loss Response: A Cohort Study
Authors: Morán-Ramos Sofía , Soriano-Cortés Ruth , Soto-Fuentes Valeria , Tenorio-Quiroz Amyris , Gervasio-Ortiz Emmanuel , Rico-Amador Dulce , Herrera Miguel , Sierra-Salazar Mauricio , Aguilar-Salinas Carlos A. , Antuna-Puente Bárbara , Rodríguez-Flores Marcela
Published: December 2023

Introduction: Roux-en-Y gastric bypass (RYGB) substantially alters the gut microbial composition which could be associated with the metabolic improvements seen after surgery. Few studies have been conducted in Latin American populations, such as Mexico, where obesity prevalence is above 30% in the adult population. Thus, the aim of this study was to characterize the changes in the gut microbiota structure in a Mexican cohort before and after RYGB and to explore whether surgery-related changes in the microbial community were associated with weight loss. Methods: Biological samples from patients who underwent RYGB were examined before and 12 months after surgery. Fecal microbiota characterization was performed through 16S rRNA sequencing. Results: Twenty patients who underwent RYGB showed a median excess weight loss of 66.8% 12 months after surgery. Surgery increased alpha diversity estimates (Chao, Shannon index, and observed operational taxonomic units, p < 0.05) and significantly altered gut microbiota composition. Abundance of four genera was significantly increased after surgery: Oscillospira, Veillonella, Streptococcus, and an unclassified genus from Enterobacteriaceae family (PFDR < 0.1). The change in Veillonella abundance was associated with lower excess weight loss (rho = −0.446, p = 0.063) and its abundance post-surgery with a greater BMI (rho = 0.732, p = 5.4 × 10−4). In subjects without type 2 diabetes, lower bacterial richness and diversity before surgery were associated with a greater Veillonella increase after surgery (p < 0.05), suggesting that a lower bacterial richness before surgery could favor the bloom of certain oral-derived bacteria that could negatively impact weight loss. Conclusion: Presurgical microbiota profile may favor certain bacterial changes associated with less successful results.
Leadership Communication in Crisis: Study of COVID- 19 Pandemic at National and Local Level
Authors: Oktaviani Fitri Hariana , Laturrakhmi Yun Fitrahyati , Kriyantono Rachmat
Published: December 2023

This chapter focuses on risk communication in the tourism sector. This chapter examines how Indonesian leaders at both national and local levels communicated during the COVID-19 pandemic. It uses the concept of discursive leadership to analyze how effective these communication efforts were in navigating the challenges posed by the pandemic. The framework of Discourse Historical Perspective is applied to analyze the language, context, and strategies used in leadership communications. This sheds light on how the central government aimed to establish credibility and legitimacy. Beyond the national leaders, we also look into how local leaders responded to the pandemic's impact on the ground. By comparing these practical situations with the larger narratives, we gain insight into where their messages aligned or diverged. Instead of just summarizing findings, this chapter offers practical suggestions based on the analysis. These recommendations guide how leadership communication can be strengthened, moving beyond retrospective thought to enhance future communication practices.
Utilization of Social Media as a Support Group to Support Chronic Disease Patients in The Endemic Era
Authors: Illahi Azizun Kurnia
Published: December 2023

Health communication is not limited to the relationship or interaction between patients and healthcare providers as the sole holders of health information. It also extends to the communication between doctors and patients during the treatment process. However, the scope of health communication encompasses more than these traditional interactions; it includes support groups as well. Support groups have been a significant component of the healthcare sector since the 1970s. Their presence is closely linked to improving health outcomes and reducing patient mortality. Receiving a challenging medical diagnosis can be a traumatic experience, and effective support systems are crucial in such cases. These support systems may involve friends, family, healthcare providers, or even patients with similar illnesses. The shared experiences among members of a support group act as a 'buffer' and can have both physical and psychological impacts, increasing adherence to the treatment process. Managing chronic diseases can become exceptionally complex for patients and their families without adequate support from their social environment. This challenge has led to the emergence of online support groups, providing individuals with the freedom to exchange information and discuss their health issues.
The Transformation of Digital Technology: Its Impact on Human Communication
Authors: Yustisia Ika Rizki , Priyanti Desi Dwi , Mulachelah Naqiyah Afifah , Kasim Azahar , Bidin Azman , Illahi Azizun Kurnia , Priyanti Desi Dwi , Tamitiadini Dian , Rakhmawati Fariza Yuniar , Oktaviani Fitri Hariana , Avicenna Fitria , Yustisia Ika Rizki , Adila Isma , Adhrianti Lisa , Wulandari Maulina Pia , Ahmad Mokhtarudin , Destrity Nia Ashton , Wardasari Nilam , Zaki Nurzalyna Mohd , Kriyantono Rachmat , Safitri Reza , Firmatoro Verdy , Laturrakhmi Yun Fitrahyati
Published: December 2023

The present state of global growth, which is now focused on the process of digitalization and the establishment of information technology networks, has emerged as a fundamental component within the realm of Public Relations professionals. The field of Public Relations has seen significant transformation via digitalization as practitioners have adapted their strategies to meet the increasing needs and expectations of stakeholders. Incorporating digital communication platforms, big data, and Artificial Intelligence (AI) has necessitated Public Relations practitioners to acquire a thorough proficiency in a new array of digital abilities. The primary objective of this preliminary research was to examine the digital skills and competencies shown by public relations practitioners in Indonesia. A quantitative research method was undertaken to investigate the implementation of Digital Public Relations in Indonesia, with surveys as the primary technique of data collecting. The study included participation from many public relations practitioners from diverse organizations as survey respondents. The study revealed that the emergence of Digital Public Relations, together with its accompanying technological advancements, has facilitated the tasks of Public Relations professionals, hence potentially enhancing their efficiency and productivity. Furthermore, many Public Relations professionals in Indonesia have already acquired the necessary knowledge and skills in digital public relations. In addition to possessing knowledge and competencies in Digital Public Relations, it is observed that a significant number of Public Relations practitioners lack practical skills in analysing the vast amount of data pertaining to their organizations on the internet and other social media platforms.
Modelagem da informação no processo de formação do planejador urbano: o caso da sistematização dos dados da covid-19 em fortaleza
Authors: Soares Mateus da Silva , Guimarães Carolina Jorge Teixeira , Cardoso Daniel Ribeiro
Published: December 2023

A cidade abriga na contemporaneidade uma sociedade complexa e diversa, o que faz com que o planejamento urbano passe por grandes transformações. Por isso, a realidade atual das grandes metrópoles incorpora as Tecnologias da Informação e Comunicação (TIC’s) em seus fluxos de capital, serviços e funcionamento. A modelagem da informação no processo de planejamento surge como uma resposta às transformações e oportunidades até agora apresentadas. Diante deste cenário, o presente artigo busca discutir os novos métodos e ferramentas de modelagem da informação e reforçar sua importância na formação do planejador a partir da observação de experiências desenvolvidas no âmbito acadêmico, principalmente em um contexto onde o mundo se depara com grandes transformações das estruturas sociais por conta da pandemia de Coronavírus.
Método de documentação de artefatos vernaculares: procedimentos e aplicações
Authors: Sampaio Hugo Guimarães , Jorge Leonardo Luna de Melo , Fiuza Rafael Mourão , Lima Mariana Monteiro Xavier de , Cardoso Daniel Ribeiro , Simões Paulo Jorge Alcobia
Published: December 2023

A documentação para preservação de patrimônio focada apenas na representação das instâncias materiais não abrange diversos aspectos intangíveis relevantes para salvaguarda. O problema do estudo trata-se da identificação de um modo de incrementação do alcance dos métodos de documentação, focando não só no objeto final, mas também em sua tipologia, composição e processo de formação. O presente trabalho propõe um método de documentação de artefatos vernaculares baseado no modelo paramétrico, que seja capaz de representar não apenas os objetos tangíveis, mas também aspectos intangíveis de sua tipologia. O método proposto foi construído por meio de Design Science Research, pois produz um procedimento científico inovador capaz de estender o alcance dos métodos de documentação. O produto desenvolvido foi um procedimento sistemático que parte da observação de uma determinada tipologia, cujo objetivo é desenvolver uma Modelagem de Processo em interface computacional. Essa maneira de documentar um conjunto de artefatos representa uma composição sistêmica da tipologia: seus elementos, suas relações e seu processo. Portanto, a implementação documental computacional proposta tem ênfase na tipologia e generalização dos artefatos, para, então, representar as instâncias individuais. O texto desenvolve uma implementação do método em uma tipologia naval vernacular típica do município de Icapuí, Ceará, Brasil: os botes “triângulo a vela”. A contribuição resultante foi a expansão dos métodos de documentação de memória no campo do Design por meio da proposição de um método inovador.
O emprego da fotogrametria digital e da parametria para evidenciar os efeitos anamórficos de elementos construtivos da arquitetura eclética pelotense
Authors: Xavier Junior Edemar , Silva Adriane Borda Almeida da , Nunes Cristiane dos Santos , Pires Janice de Freitas
Published: December 2023

Alguns exemplares da arquitetura eclética pelotense, erguidos no final do século XIX, comprovam a atuação de profissionais com a habilidade de produzir efeitos anamórficos, os quais induzem a uma percepção específica sobre a forma desde um determinado ponto de vista. Este estudo, de interesse didático e investigativo, exercita a representação de dois elementos construtivos desta arquitetura: a meia cúpula da Capela da Santa Casa, percebida como cúpula inteira, de autoria do arquiteto José Isella, e a claraboia do Casarão-sede do Museu do Doce, percebida como um olho, de autoria ainda desconhecida. Por meio de procedimentos que envolvem a fotogrametria digital e a parametria, são produzidas representações que buscam explicitar as posições relativas entre as partes dos elementos para a geração dos efeitos citados. Estas representações resultam em recursos digitais, interativos, com diferentes níveis de abstração: do modelo tridimensional fotorrealista ao modelo conceitual. Tais recursos têm facilitado a manipulação dos modelos digitais dos elementos arquitetônicos para um despertar sobre a lógica projetual envolvida na produção dos efeitos identificados. Além de investir no processo formativo sobre anamorfismos, por meio de tecnologias digitais, foram incrementados os recursos e discursos para serem utilizados em ações de valorização do patrimônio abordado, os quais subsidiam o avanço na produção de hipóteses da autoria de José Isella sobre o projeto da claraboia.
Obtenção da forma funicular de cascas reticuladas rígidas com painéis quadrangulares planos
Authors: Moura Ana Beatriz de Medeiros , Silva Felipe Tavares da
Published: December 2023

As cascas funiculares acompanham a história da arquitetura, engenharia e construção desde a antiguidade, apresentando tanto a vantagem de serem compatíveis com materiais pétreos quanto a capacidade de atingir grandes vãos. Com o desenvolvimento industrial e principalmente desde o século XX houve o grande avanço na construção de versões reticuladas destas cascas, trazendo consigo vantagens em aspectos arquitetônicos e construtivos quando comparadas à versão maciça. Atualmente, já há uma consolidação sobre as formulações matemáticas dos métodos de obtenção da forma funicular, mas com o desenvolvimento recente dos computadores e das ferramentas de simulação paramétricas há uma oportunidade diversificada de implementação desses métodos por meio de algoritmos computacionais. Contudo, não está relatado claramente na literatura como essas implementações podem ser realizadas utilizando as ferramentas paramétricas disponíveis. Neste artigo, são apresentados os resultados de experimentações destas implementações com algoritmos computacionais usados para a obtenção da forma funicular, desenvolvidas no ambiente de programação visual do Grasshopper no Rhinoceros3D. Adicionalmente, para demonstrar a eficácia construtiva, foram implementados e experimentados algoritmos de regeneração, de mensuração da planaridade e de planarização de faces quadrangulares em malhas poligonais. As experimentações apresentaram resultados válidos, comparando entre si o desempenho dos métodos e esclarecendo sobre a variabilidade de resultados diferentes que estes processos podem gerar. Estes resultados vêm a contribuir para o desenvolvimento do ensino, concepção, projeto e construção de cascas reticuladas rígidas em forma funicular.
Atrizes e personagens mulheres no cinema da América Latina (1930-1940)
Authors: Gillone Ana Daniela De Souza
Published: December 2023

O presente artigo tem como objetivo discutir e analisar os aspectos estéticos, políticos e sociais das representações de mulheres no cinema latino-americano produzido nas décadas de 1930 e 1940. As caracterizações das personagens femininas são analisadas nos filmes Limite (Mário Peixoto, Brasil, 1931), Enamorada (Emilio Fernández, México, 1948) e Mujeres que trabajan (Manuel Romero, Argentina, 1938). A proposta é caracterizar a mulher que se manifesta nos temas do trabalho, gênero, política e sociedade passando pelas revoluções e momentos políticos dos países latino-americanos, para além da perspectiva crítica às suas condições simbólicas, frisando uma leitura de resistência que pense a questão do ponto de vista do feminismo, das epistemologias latino-americanas e da teoria fílmica. Essa análise se estende às mulheres soldaderas da Revolução Mexicana, à mulher em sua condição de trabalhadora que consegue emancipação pelo trabalho e consumo no cinema argentino, às mulheres trabalhadoras, prostituta, costureira e dona de casa, em condições menos formais no cinema brasileiro. As relações entre representações do feminino e a política dessas cinematografias são vistas para além das estratégias, estéticas e narrativas, desenvolvidas pelos realizadores para a elaboração de seus conteúdos. Interessa encontrar nos liames as relações da atriz com seu personagem, que contemple a gestualidade que possa vir a romper com padrões definidos para constituir um discurso que escape de normativas impostas a elas historicamente.
Las Calles son nuestras (y las imágenes, también)
Authors: Rocca Paola Cortes
Published: December 2023

Este artículo aborda una serie de imágenes tomadas por colectivos fotográficos y fotografxs activistas, de las movilizaciones ocurridas en Argentina desde el surgimiento de la marea feminista en 2015 y en torno al reclamo por la ley de aborto seguro, legal y gratuito sancionada en 2020.  Desde una perspectiva teórico-crítica pero también desde la experiencia de la participación en el colectivo de activistas Ni Una Menos, se exploran la visualidad feminista como un modo de representación y visibilización de la marea en el espacio público, pero también como una herramienta de autorrepresentación que se enlaza con la masividad del movimiento en el nuevo milenio, la ocupación callera y la intervención digital, las pequeñas y grandes interrupciones en el relato patriarcal. La hipótesis nodal es que el feminismo se constituye como un aparato de inteligibilidad, es decir, como un modo de hablar y producir imágenes, de leer y ver el mundo. Esta relación entre palabra e imagen, implica también una intervención político-estética, que hace uso estratégico de la performatividad e implica un modo distintivo de construir presente y futuro.
Fiçcão visionária e anticolonialidade no filme "o que não tem espaço está em todo lugar", de Jota Mombaça
Authors: Gonçalves Fernando do Nascimento
Published: December 2023

O artigo discute o filme-ensaio “O que não tem espaço está em todo lugar” (2020), da artista visual Jota Mombaça, que realiza debates sobre racismo interseccionado com classe, gênero e sexualidade através de textos, performances, instalações, filmes e fotografias. Realizado durante a pandemia do Covid-19, o filme é uma espécie de diário de viagem fabulado a partir da ressignificação de arquivos de deslocamentos da artista entre Lisboa, Fortaleza e Berlim. Com ele, a artista faz um manifesto contra a violência e exclusão de corpos e subjetividades que não se encaixam no modelo moderno-capitalístico do homem ocidental, branco, cisgênero e heterossexual. O texto discute as operações enunciativas acionadas no filme e seu papel na crítica de Mombaça a essas lógicas de violência. Conclui-se que tais estratégias, por um lado, impregnadas de gestos de errância, velocidade e instantaneidade, corporificam dores e interdições, mas, por outro, implicam um pacto com a vida, no qual corpos e subjetividades dissidentes, exatamente por não poderem existir no mundo, precisam ser afirmados em todo lugar.
Latinos na mídia: um panorama evolutivo da televisão norte-americana
Authors: Lins Marcella
Published: December 2023

Em Latino TV: A History, a professora Mary Beltrán traça uma retrospectiva histórica da televisão norte-americana, elencando as diversas mudanças ocorridas na indústria, em matéria de representação de personagens hispânicos, da relação da população hispânica residente nos Estados Unidos com a mídia mainstream e da importância de membros da comunidade como produtores e criadores de conteúdo. Por meio da leitura de episódios de programas específicos, de materiais promocionais e de críticas difundidas na sociedade em diferentes momentos - além da realização de entrevistas com profissionais do meio -, Beltrán consegue demonstrar como os padrões de representação são compostos por normas culturais e paradigmas da indústria, de acordo com o período em que são produzidos. Cada capítulo do livro aborda uma década diferente, desde os anos 1950 aos anos 2010. Nesta nova década que se inicia, 24% da audiência televisiva entre jovens adultos é de ascendência latina. Frente a esse cenário, Latino TV: A History se mostra essencial para compreender como a indústria se organiza para atender a esse importante mercado consumidor.
El barrio de San Pedro en la historia de Valladolid Morelia
Authors: Chávez Jaime Alberto Vargas
Published: December 2023

Este estudio narra el fenómeno de las transformaciones urbano-arquitectónicas acaecidas en el valle de Guayangareo a partir de los asentamientos indígenas mesoamericanos (siglo XV). Comprende el establecimiento de las primeras estancias de españoles en este sitio; los esfuerzos y actores involucrados en la fundación de la nueva Ciudad de Guayangareo de Mechoacan (1541), después Valladolid y finalmente Morelia (1828); y profundiza en el tema de barrios de indios, particularmente el de San Pedro, a través de una novedosa metodología de investigación soportada en la confrontación de la cartografía antigua, planteada ante la ausencia de datos historiográficos, que nos acerca a la evolución de este espacio cuando se transfigura de barrio a Paseo de San Pedro en la época decimonónica, con el diseño del ingeniero belga Guillermo Wodon de Sorinne, hasta 1916, cuando se le renombra como Bosque Cuauhtémoc.
Autos de infração ambiental e ocupação territorial do município de cruzeiro (sp)
Authors: Coutinho Marcos Pellegrini , Santos Leandro Lucena dos , Chrispim Eduardo Henrique Sanches , Costa Olívia Mendes Leal , Souza Arley Ferreira de , Pagotto Erico Luciano
Published: December 2023

A legislação brasileira estabelece que as infrações ambientais sejam registradas pelo poder público por meio de Autos de Infração Ambiental (AIA). O presente estudo espacializou e analisou os AIAs do município de Cruzeiro (SP) de 2003 a 2021. Os resultados mostraram que houve um aumento no número de AIAs ao longo do tempo, sendo registrados principalmente nas proximidades de estradas e cursos d’água de áreas periféricas urbanas. Quanto às unidades de conservação presentes no município, o Monumento Natural da Mantiqueira Paulista (MoNA) foi o que apresentou mais registros de crimes ambientais em seu entorno. No geral, atribui-se o aumento no número de registros de AIA à estruturação dos órgãos ambientais após a década de 1990. Esta pesquisa revelou-se importante como subsídio ao planejamento ambiental tanto no que se refere ao estímulo de projetos de recuperação da vegetação, como para programar ações educativas, como determina o Plano Municipal da Mata Atlântica (PMMA) e, também, para subsidiar ações de fiscalização, de forma a reduzir os crimes ambientais.
A literatura portuguesa na educação básica: uma história de futuro?
Authors: Fritzen Celdon
Published: December 2023

Este artigo se propõe discutir o lugar contemporâneo da literatura portuguesa entre as leituras literárias da Educação Básica. Para isso, aborda-se a função de reforço do paradigma vernáculo que a literatura portuguesa assumiu no ensino de Língua Portuguesa desde o Império. Depois, analisa-se a presença da literatura portuguesa em uma amostra de listas de obras literárias para os vestibulares de IES brasileiras e de questões de Língua Portuguesa do ENEM. Por fim, ainda se verifica nessa amostra se a lusofonia, em consonância com algumas políticas públicas, não se mostraria como o novo paradigma de leitura literária. A análise indica pouca expressividade da literatura portuguesa na amostra.