bluuebunny/crossref_metadata_2025 huggingface dataset:
MiR-28-3p enhances healing of fracture via negative regulation of the target gene Sox6 and activation of PI3K/Akt signaling pathway
Authors: Li Wei , Dong Xin , Zhao Jian
Published: January 2021

Purpose: To investigate the effect of miR-28-3p on fracture healing, and the involvement of Sox6 gene and PI3K/Akt signaling pathway in the process.Methods: Mouse osteoblast cell lines were cultured in vitro, and miR-28-3p over-expression and inhibitory plasmids were separately added to the medium. The corresponding control groups were set up. Real-time quantitative polymerase chain reaction (qRT-PCR) was used to measure the mRNA expressions of the osteogenesis-related genes Col1a1, Col-Ⅱ and Col-X in osteoblasts. The protein expressions of Sox6, Col1a1, Col-Ⅱ, Col-X, PI3K, p-PI3K, Akt and p-Akt in rat cartilage tissue were determined with Western blotting assay.Results: The expression of Sox6 protein in the miR-28-3p over-expression group was significantly reduced, when compared with the miR-28 overexpression control, but Sox6 protein expression in the miR-28-3p inhibition group was significantly increased, relative to inhibition control group (p < 0.05). In the miR-28-3p over-expression and Sox6 over-expression groups, Col1a1 protein expression was significantly increased, while Col-Ⅱ and Col-X protein expressions decreased, when compared with the respective over-expression control group (p < 0.05). Over-expression of miR-28-3p markedly upregulated phosphorylation levels of PI3K and Akt, relative to over-expression control group, while miR-28-3p inhibition significantly downregulated the phosphorylations of PI3K and Akt, relative to the inhibition control group (p < 0.05).Conclusion: Over-expression of miR-28-3p may enhance the healing of fractures by induction of PI3K/Akt signaling route via negative regulation of the expression of Sox6 gene.

Keywords: MiR-28-3p, Sox6, PI3K/Akt signaling pathway, Fracture healing
ARPC4 gene silencing inhibits T24 cell invasion and metastasis via a mechanism involving Arp2/3/cofilin-1 signaling pathway
Authors: Pang Shunyi , Yao Zeqin , Wang Chao , Chen Guoqiang
Published: January 2021

Purpose: To study the influence of ARPC4 gene silencing on human urinary bladder cancer (T24) cell proliferation, invasiveness and migration, and the mechanism(s) involved.Methods: Short interfering RNA (siRNA) ARPC4 silencing fragment was transfected into T24 cells. Transfection efficiency was measured with qRT-PCR. Cell proliferation, invasiveness and migratory potential were determined with CCK-8, Transwell invasion assay, and immunofluorescence assay,respectively. Protein expressions of ARPC4 and cofilin-1 were assayed using Western blotting.Results: Short interfering RNA (siRNA) silencing of ARPC4 gene led to the downregulation of mRNA and protein expressions of ARPC4 (t = 14.898, p < 0.05; t = 7.686, p < 0.05). It also significantly downregulated cofilin-1 protein, while inhibiting proliferative capacity, invasiveness and pseudopodiaformation capacity of T24 cells (t = 8.042, p < 0.05).Conclusion: The results obtained suggest that ARPC4 gene silencing inhibits T24 cell invasion and metastasis via a mechanism involving regulation of the Arp2/3/cofilin-1 signaling route. This provides new leads for gene therapy.

Keywords: ARPC4, Bladder carcinoma, Gene silencing, Invasiveness, Cell proliferation
Crassifoside H ameliorates depressant behavior in chronic unpredictable mild stress rats by improving HPA axis dysfunction and inhibiting inflammation in hippocampus
Authors: Li Huina , Wu Kefan , Zhang Yue , Li Ning , Wang Kaijin
Published: January 2021

Purpose: To investigate the antidepressant mechanism of action of Crassifoside H (CH) from the rhizomes of Curculigo glabrescens (Hypoxidaceae) in chronic unpredictable mild stress (CUMS)-induced rats.Methods: CUMS-induced rat depressant model was established. Behavioral tests, viz, sucrose preference test (SPT), open field test (OFT) and forced swimming test (FST) were applied to assess the antidepressant effect of CH. Enzyme linked immunosorbent assay (ELISA) was used to assess thelevels of corticosterone (CORT), TNF-α and IL-1β in serum. Protein expressions of TNF-α, IL-1β and NLRP3 in rat hippocampus were determined by Western blot.Results: Crassifoside H significantly ameliorated CUMS-induced depressant-like behavior as the serum CORT level of CUMS rats. CH remarkably decreased TNF-α and IL-1β levels in serum and hippocampus of CUMS rats. Moreover, Crassifoside H significantly inhibited NLRP3 activation inhippocampus.Conclusion: The findings demonstrate that Crassifoside H has antidepressant effect on CUMS rats. The mechanism of action of CH may be at least partly due to the improvement of hypothalamic-pituitaryadrenal (HPA) axis dysfunction by decreasing serum CORT. These findings suggest that Crassifoside H has a therapeutic potential for the management of depression.

Keywords: Crassifoside H, Antidepression, Curculigo glabrescens, Hypoxidaceae, Hypothalamicpituitary- adrenal axis, Inflammation, Corticosterone
Effect of Abelmoschus esculentus (okra)-based diet on streptozotocin-induced diabetes mellitus in adult Wistar rats
Authors: Uadia Patrick O. , Imagbovomwan Isaac O. , Oriakhi Kelly , Eze Ikechi G.
Published: January 2021

Purpose: To evaluate the effects of an okra-based diet on streptozotocin-induced diabetes mellitus in adult Wistar rats and its mechanism of action.Methods: Wistar rats (6) were administered streptozotocin (50 mg/kg ip) after an overnight fast. Upon confirmation of diabetes mellitus, the animals were fed ad libitum for 21 days with formulated okrabased test diet in place of normal diet. The rats treated similarly with streptozotocin and fed ad libitum with the normal diet served as diabetic control while rats fed on normal diet and not treated with streptozotocin served as the negative control. Thereafter, the rats were sacrificed, fasting bloodcollected and analysed for glucose concentration and biochemical parameters. Pancreas was also excised for histopathological studies.Results: There was a significant increase in body weight, HDL-cholesterol (p< 0.05) but significant decrease in blood glucose (p < 0.05), serum total cholesterol, triglyceride, LDL-cholesterol and VLDLcholesterol concentrations in the okra-fed diabetic treated rats when compared to the diabetic control group. Furthermore, superoxide dismutase activity (SOD) was significantly higher in the diabetic control, and reduced significantly when fed with okra-based diet (p < 0.05). Catalase (CAT) activity was significantly (p < 0.05) decreased in diabetic control and treated group, whereas it was significantly (p < 0.05) increased in normal control rats. There was a significant (p < 0.05) decrease in reduced glutathione levels. The significant (p< 0.05) increase in malondialdehyde in the diabetic group was significantly decrease in the diabetic rats fed with okra-diet. Also serum insulin level was significantly (p < 0.05) increased and serum α amylase activity was significantly (p < 0.05) decrease in the diabetic treated rats. Histology results show that there was damage to the β cells of the pancreas in the diabetic control when compared to normal control, but rats fed okra diet was able to regenerate endocrine β cells.Conclusion: Okra-based diet lowers hyperglycaemia as well as regenerate/repair endocrine β-cells and exocrine tissues of the pancreas damage by streptozotocin

Keywords: Abelmoschus esculentus, Diabetes mellitus, anti-diabetic, Insulin, α-amylase, Mechanism
Inhibition of miR-665 alleviates neuropathic pain by targeting SOCS1
Authors: Lin Yongqiang , Li Mengjia , Rao Gaofeng , Zhang Wenfu , Chen Xuyan
Published: January 2021

Purpose: To investigate the effect of miR-665 in neuropathic pain and the possible molecular mechanism involved.Methods: A neuropathic pain model was established using chronic constriction injury (CCI) methods in Sprague Dawley (SD) rats. Mechanical and thermal hyperalgesia were measured using paw withdrawal threshold (PWT) and paw withdrawal latency (PWL), respectively. The inflammation response was determined by assessing the production of inflammation factors. The target relationship of miR-665 and suppressor of cytokine signaling 1 (SOCS1) was verified by luciferase assay.Results: In the CCI rat model, PWT and PWL decreased following treatment with miR-665 (p < 0.01). MiR-665 was elevated in the spinal cord and microglia of CCI rats at different time points (p < 0.01). Down-regulation of miR-665 increased PWT and PWL and inhibited the production of interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α in CCI rats (p < 0.01). Luciferase assay results indicate that SOCS1 was the target of miR-665 (p < 0.01). SOCS1 decreased in CCI rats (p < 0.01) after treatment with miR-665. MiR-665 negatively regulated the expression of SOCS1 (p < 0.01). Down-regulation of SOCS1 reversed the alleviating effect of decreased miR-665 on pain sensitivity and inflammationresponse (p < 0.01).Conclusion: Down-regulation of miR-665 alleviates neuropathic pain by targeting SOCS1, and hence making miR-665 a promising therapeutic target for neuropathic pain.

Keywords: MiR-665, SOCS1, Neuropathic pain, CCI, Spinal cord
Quinolinol-platinum (II) complex suppresses survival and invasion of laryngeal cancer cells via targeting YESassociated protein expression
Authors: Xie Baotong , Li Tao
Published: January 2021

Purpose: To investigate the anti-proliferative potential of quinolinol-platinum (II) complex {QN-Pt (II)} in laryngeal cancer cells.Methods: The inhibitory potential of QN-Pt (II) on the proliferation of laryngeal cancer cells was determined using 2H-tetrazolium, 2-(4,5-dimethyl-2-thiazolyl)-3,5-diphenyl bromide (MTT) and colony formation assays. Inhibition of cell migration was determined using wound-healing assay, while changes in LC3-II and p62 expressions were assessed by western blotting.Results: QN-Pt (II) inhibited the viability of TU212 and M4e laryngeal cancer cells in the concentration range of 2 to 10 μM (p < 0.05). Moreover, it  suppressed the colony formation potential and migration of TU212 and M4e cells. The QN-Pt (II) treatment increased the proportion of TU212 and M4e cells in G1/G0 phase of the cell cycle, but decreased the cell proportion in S and G2/M phase (p < 0.05). Treatment with 10 μM QN-Pt (II) increased the expression of LC3-II, but downregulated P62 expression in TU212 and M4e cells. The expression of Yes-associated protein was inhibited in TU212 and M4e cells on treatment with QN-Pt (II). However, transfection of YAP-cDNA into TU212 and M4e cells reversed the inhibitory effect of QN-Pt (II) on cell proliferation (p < 0.05). Moreover, YAP-cDNA transfection suppressed LC3II expression, inhibited YAP phosphorylation and promoted P62 expression in QN-Pt (II)-treated TU212 and M4e cells (p < 0.05).Conclusion: QN-Pt (II) suppresses laryngeal cancer cell viability via arrest of cell cycle and activation of apoptosis. Moreover, QN-Pt (II) targets Yes-associated protein in laryngeal cancer cells. Thus, QN-Pt (II) is a potential therapeutic agent for laryngeal cancer.

Keywords: Laryngeal cancer, YAP-protein, Apoptosis, Phosphorylation, Therapeutic agent
Can loss aversion shed light on the deflation puzzle?
Authors: Lye Jenny N. , McDonald Ian M.
Published: January 2021

This paper argues that the application of loss aversion to wage determination can explain the deflation puzzle: the failure of persistently high unemployment to exert a persistent downward impact on the rate of inflation in money wages. This is an improvement on other theories of the deflation puzzle which simply assume downward wage rigidity, namely the hysteresis theory, the lubrication theory and the efficiency wage theory. The paper presents estimates that support the loss-aversion explanation of the deflation puzzle for both the US and Australia. Furthermore, our estimation approach gives a more precise estimate of the potential rate of unemployment than does the natural rate approach and reveals potential rates of unemployment for the US and Australia at the end of 2017 of about 4 per cent and 3.3 per cent respectively.
Systems Theory: Simulation Analysis of Space Charge Generation Mechanisms in Transformer Oil under High Electric Field
Authors: Zhu Hui , Mastorakis N. E. , Lei Qingquan
Published: January 2021

Simulation analysis plays an important role in Systems Theory nowadays. In order to reveal the mechanism of space charge injection and generation in the process of liquid dielectric breakdown, the discharge of transformer oil between needle-plane electrodes under high electric field is studied. Based on the 2-D hydrodynamic model and Poisson equation of electric field, the system simulation model of oil discharge by different charge generation mechanism is established, based on which the inception and propagation process of discharge is simulated by COMSOL. By system simulation, the temporal and spatial distribution of the electric field intensity, space charge density, electric potential and temperature of transformer oil is obtained and deeply analyzed. The simulation results prove that the space charge generated by metal field emission and ionic disassociation are neither of the major factor for streamer formation in transformer oil, while the Zener molecular ionization and impact ionization are the major factors. Our research improves the understanding of the inception, propagation and breakdown process for discharge in transformer oil, and also the ionization mechanism in the liquid dielectric
PENGARUH GEL EKSTRAK BAWANG PUTIH (ALLIUM SATIVUM L.) TERHADAP JUMLAH SEL MAKROFAG PADA PENYEMBUHAN LUKA INSISI GINGIVA MARMUT (CAVIA PORCELLUS)
Authors:   Departement Oral Maxillofacial Surgery Faculty of Dentistry Mahasaraswati University Denpasar, Poernomo Hendri , Ma'ruf M. Taha
Published: January 2021

Surgical with an incision or tissue incision process can cause injury or tissue damage to the oral cavity, especially the gingiva. Wound healing can last a long time, this condition can increase the potential for complications such as infections and less blood supply. Garlic contains several active substances including flavonoids, tannins, phenols and alkaloids, and organosulfur compounds namely allicin. The content is believed to stimulate macrophage cells and help the work of macrophages in cleaning the wound area so that it accelerates into the phase of proliferation and wound healing. The research method was experimental laboratory research with a post-test design group. The results showed that the average number of macrophage cells in the control group CMC-Na 2% 97,50 cells, mean group of 40% garlic extract gel was 58,83 cells, mean group of 50% garlic extract gel was 18,00 cells, mean 60% garlic extract gel group was 7,83 cells. The results showed that there are significant differences (ρ <0,05) in the four study groups. Garlic extract gel concentration of 60% was more effective in reducing the number of macrophage cells in guinea pig gingival incision because of the percentage of active content.
PERBANDINGAN EFEKTIVITAS EKSTRAK DAUN BINAHONG (ANREDERA CORDIFOLIA (TEN.) STEENIS) 25% DAN 50% DIBANDINGKAN OBAT TRIAMCINOLONE ACETONIDE TERHADAP PENYEMBUHAN RECURRENT APHTHOUS STOMATITIS (RAS) MINOR
Authors:   Department of Oral Medicine, Faculty of Dentistry, Mahasaraswati University Denpasar, Sari Ni Nyoman Gemini , KD Intan
Published: January 2021

Recurrent Aphthous Stomatitis (RAS) is an inflammation of the soft tissues of the mouth characterized by recurrent ulcers without symptoms of other diseases. Clinically, RAS is characterized by painful recurrent ulcerations of the oral mucosa that appear recurrently in single or multiple numbers and have a red halo appearance that usually appears on the lip, cheek, lateral, and ventral mucosa of the tongue in the oral cavity. Triamcinolone acetonide is a prednisolone derivative and is considered an intermediate glucocorticoid. It is effective in reducing the signs and symptoms of many conditions of inflammation of the mouth, including RAS. Binahong contains active compounds of flavonoids, alkaloids, terpenoids, and saponins which have an antibacterial effect in inhibiting the growth of Streptococcus mutans and Staphylococcus aureus bacteria. so Binahong leaf extract can be used as an alternative natural treatment for minor RAS. This research compared the effectivity of extracts leaves Binahong (Anredera cordifolia (Ten.) Steenis) concentrations of 25%, 50% with Triamcinolone Acetonide in healing Recurrent aphthous stomatitis (RAS) minor. The research was pretest-posttest control group design, 30 samples divided into 3 treatment groups, where the treatment group I used Triamcinolone acetonide, treatment group II used 25% binahong leaf extract, and treatment group III used 50% Binahong leaf extract. Data were analyzed with a parametric statistical test of paired sample T-test and showed that there was a significant decrease in RAS diameter in groups I, II, and III (p <0.05). The mean difference of RAS diameter between-group in order 2.7mm for the first treatment group, in the second treatment group, was 1.3mm and 2.2mm for the third treatment group. Analysis with Oneway ANOVA showed that after the treatment was given to the three groups, there was a significant average difference of the minor RAS diameter decrease (p <0.05). The results showed that Triamcinolone acetonide was more effective in accelerating the healing of minor RAS than 25% and 50% binahong leaf extract.
PERENDAMAN DENGAN PERASAN BUAH JERUK LEMON (Citrus lemon) DAPAT MENURUNKAN KEKERASAN RESIN KOMPOSIT NANOHYBRID
Authors:   FKG Unmas Denpasar, Tista IGN Bagus , Hartini IGAA Hartini , KDA IA. Gitasanthi ,   Mahasiswa program Sarjana, FKG Unmas Denpasar
Published: January 2021

Composite resin is a restoration material that is often used because the composite resin has good aesthetic value like mimetic the teeth color. Composite resins have a physical and mechanical condition. One of the mechanical condition is hardness. The surface hardness of composite resins is the surface resistance of the composite resin material to the applied pressure. One of the factors influencing composite hardness is the food and beverages consumed. Consuming acidic drinks continuously for a long time period can erode composite resin filling. The purpose of this study was to determine the effect of soaking into a citrus lemon on the hardness of nanohybrid composite resin. This type of research was true experimental with pre-test post-test with control group design using 24 composite resin samples which are divided into 4 groups with 6 samples each. The groups in this study were nanohybrid composite resins soaked with citrus lemon and aqua dest for 60 minutes and 120 minutes. The hardness tested using a Vicker hardness tester. The results of the study using the LSD (Least Significant Difference) test showed that the significance value of p= 0.014 (p<0.05), which means that the use of citrus lemon for 120 minutes affected the hardness of nanohybrid composite resin. In conclusion, soaking with citrus lemon for 120 minutes reduces more the hardness of nanohybrid composite resin compared with soaking for 60 minutes.
ETIOLOGI, DAMPAK DAN MANAJEMEN EARLY CHILDHOOD CARIES (ECC)
Authors:   Bagian Ilmu Kedokteran Gigi Anak, Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar, Astuti ES. Yuni
Published: January 2021

Early childhood caries (ECC) is one of the most prevalent diseases in children worldwide. Streptococcus Mutans is the main bacteria that have a strong association with ECC, and these bacteria can be transmitted from mother to child. ECC does not only affect children’s oral health but also the general health of the children and the end affects their quality of life. The impacts of ECC such as problems with sleeping, speaking eating, premature loss of primary dentition, and this condition often leads to orthodontic problems in adult life. Management of ECC has begun preventive strategies, curative and rehabilitative treatment also. As we know the etiology and management of ECC, the impact can be avoided, and the children still have a good quality of life.
PENATALAKSANAAN FRAKTUR ELLIS KELAS III 11 DENGAN PULPEKTOMI DAN RESTORASI MAHKOTA PASAK
Authors:   Departemen Gigi dan Mulut, Program Studi Sarjana Kedokteran Gigi dan Profesi Dokter Gigi, Fakultas Kedokteran, Universitas Udayana, Bali, Indonesia, Sidiartha IGA Fienna N , Wiswananta P Putu ,   Program Studi Profesi Dokter Gigi, Program Studi Sarjana Kedokteran Gigi dan Profesi Dokter Gigi, Fakultas Kedokteran, Universitas Udayana, Bali, Indonesia
Published: January 2021

A 19-year-old male patient came to Unud Hospital with a complaint that his upper right front tooth was broken. The patient's right front toothaches when he consumes cold food or drinks and bleeds every morning. Pain still exists even if food or cold drinks are removed. Complaints felt since 7 months ago. The tooth now feels pain but is not as severe as the initial tooth fracture. Patients have consumed mefenamic acid to reduce pain. The tooth has never been treated by a dentist. The patient is now treated with pulpectomy accompanied by a fused to metal porcelain jacket crown restoration with a cast post-core. After controlling for one week after treatment, the desired result is the loss of subjective and objective complaints in the patient.
Intuitive Feeling of Closeness to Solution Preceding Insight in Anagram Tasks
Authors:   Institute of Psychology RAS, Medyntsev Alexey , Kogan Alena , Sabadosh Pavel , Dyatlova Olga , Nemirova Svetlana , Kayutina Diana
Published: January 2021

One of the main research questions related to creativity is the dilemma of specificity vs. non-specificity of the mechanisms underlying insight solutions as compared to analytical solutions of a problem. The first goal of our study was to verify insight solution specificity on solving anagram tasks. The second goal was to test a hypothesis about the existence of unconscious processing prior to insight solutions. We presented two types of stimuli to participants: anagrams and pseudowords. During the experiment, participants had to perform two successive tasks. First they had to judge whether they were being shown an anagram or a pseudoword, and then they had to solve the anagram. Anagrams and pseudowords differed in some visual features, of which the participants were not aware. It was expected that unconscious processing (if it exists) would be influenced by the implicit difference between the appearance of stimulus categories. During the solving process, participants had to rate how close they were to a solution. After a successful solution, they also had to indicate which way they found it: analytically or with insight. Our results showed that prior to an insight solution, participants felt that they were farther from the final solution than in the case of an analytical solution. These results confirm Metcalfe and Wiebe’s (1987) conclusions on the difference between insight and analytical solutions. According to these data, we can propose different specific mechanisms for insight solutions and analytical solutions in anagram tasks. At the same time, the presence of visual differences between stimulus categories did not influence the anagram solving process. The current results did not show evidence for an important role of unconscious processing before insight solutions of anagrams
Análisis de las variables afectivo-motivacional de los estudiantes del segundo ciclo de secundaria con dificultades matemáticas en dos centros educativos
Authors: Faña Villar María Eugenia
Published: January 2021

La investigación trata sobre las variables afectivo-motivacional que presentan los estudiantes del segundo ciclo de secundaria en la clase de matemática. La investigación surge a través de los resultados de las investigaciones de PISA, Serce y Terce, donde República Dominicana obtuvo puntuaciones por debajo del promedio. Estos resultados son los que han motivado la realización de este estudio, ya que es importante conocer, desde el punto de vista de la psicología, para poder dar respuestas a algunos factores internos y a las variables afectivas que pueden incidir o condicionar a los estudiantes dominicanos en el rendimiento de las matemáticas, lo que dificulta el cumplimiento de los indicadores de logros que se requieren en cada nivel. Esta es una investigación de tipo cualitativa y diseño narrativo, que pretende analizar y describir las situaciones psicológicas que producen las matemáticas en los estudiantes del segundo ciclo de secundaria. La investigación fue realizada en dos centros educativos, a través de entrevistas y grupos focales, para luego hacer un análisis y descripción de la situación.
State-Building in Belarus: The Politics of Repression Under Lukashenko’s Rule
Authors:   Eurasia Institutes, Terzyan Aram
Published: January 2021

This paper explores the politics of repression and coercion in Belarus, with a focus on the Belarusian authorities’ brutal responses to dissident activities. While repressions are seen to be a backbone of authoritarian rule, there is a lack of case studies of repressions and repressive policies in different kinds of authoritarian regimes and their interaction with other mechanisms of authoritarian sustainability. As Belarus has demonstrated, Lukashenko’s effort’s at perpetuating his power have prompted his regime into increasing the role of repressions. Coercion and repression have been critical to suppressing dissent and pluralism across the country. Essentially, successful, mass-based opposition to the ruling elites, that led to 2014 Maidan Revolution in Ukraine and the 2018 “Velvet Revolution” in Armenia served as examples to discontented elements in Belarus. Meanwhile, to shield itself from the diffusion effects of ‘color revolutions’, the Belarusian regime has tended to reinforce its repressive toolkit through suppressing the civil society, coercing the opposition, and preventing the latter from challenging Lukashenko’s rule. This study enquires into the anatomy of repressive governance in Europe’s “last dictatorship.”
Faktor - Faktor Peranan Penggunaan Social Media E-Government: Studi Kasus Pemerintah Kota Prabumulih
Authors: Fajriyah Fajriyah , Antoni Darius , Akbar Muhammad
Published: January 2021

With the development of the era of technology and information, it has also progressed very rapidly. Social media is one of the internet-based media which has an important role in the world of government to communicate with stakeholders in this global era. Increasingly sophisticated technology makes it easier for everyone to get the information they want so that thanks to the sophistication of information technology with the help of the internet, online media is increasingly easier to access, making online media one of the alternative media for public information that is effective in meeting the needs of human interaction. The largest social networks include Facebook and Twitter. The objective of this research is to measure how much the community responds as Prabumulih's follower in receiving the information provided through social media (Facebook, Twitter or Instagram). E-government can be interpreted in various ways because basically e-government can manifest itself in various forms and scope. The factors that influence the role of social media use in Prabumulih City Government are Technology Capacity, Interaction and Social media variables. In getting respondents, the writer used a questionnaire so that 200 respondents were obtained. The data from the questionnaire was managed using the SPSS program with the AMOS analysis model. From the Estimate value obtained from each variable is as follows, Technology Capacity has an estimate value of 0.863, Interaction has an estimate value of 1.06, and Social media variables have an estimate value of 0.857. Thus proving that these variables can be said to have perfect reliability values.
Ekşi Elmalar Film Afişi Üzerine Göstergebilimsel Bir Deneme
Authors: DEMİR Kenan
Published: January 2021

İnsanoğlu tarih boyunca kendini sözlü ve yazılı olarak ifade etmenin birçok yolunu bulmuştur. Bununla birlikte görsellik, mağara resimlerinden günümüzdeki muazzam yapılara dek insanın temel ifade aracı olma özelliğini sürdürmüştür. Sinema da icadından bu yana görsel öğeler aracılığıyla bireyin kendini ifade etmesi için yeni imkânlar sunmuştur. Afişler ise bir filmi tanıtmak amacıyla hazırlanan görsel iletişim araçlarıdır ve seyircinin film hakkında fikir sahibi olması bakımından önemlidir. Bu çalışmada son dönem Türk sinemasında gerek oyuncu gerekse de yazar ve yönetmen olarak isminden sıkça söz ettiren Yılmaz Erdoğan’ın Ekşi Elmalar filminin afişi göstergebilimsel analiz yöntemi ile incelenmiştir. Böylece film afişindeki göstergelerin neyi işaret ettiğinin ortaya çıkarılması amaçlanmaktadır.
A NEW READING OF HISTORICAL ACCOUNTS ABOUT THE RULE OF THE BARBARIAN QUEEN (ELKAHINA) AND HER RESISTANCE TO THE ISLAMIC ARMY OF CONQUEST LED BY HASSAN IBN AL-NUMAN (39-74 A.H./658-693 CE)
Authors:   Université Ahmed Draia, Adrar, DJELAILI AHMED
Published: January 2021

The article tries to study the historical texts that dealt with the character of the barbarian Queen Tahia, known as the priestess, which sparked widespread controversy during the Islamic conquest, how did she reach the ruling? And the reasons for fighting the army of Hassan bin Nu'man? And its sabotage of the countries of the Maghreb by pursuing a policy of scorched earth? The problem of the number of the Queen’s children, who are three for some, and for the others two? And their fate in the end, did they convert to Islam or were they killed in battle? And the issue of adopting a son and his brotherhood with her children? After going back to the most important sources and examining the historical texts that dealt with the subject and comparing them with each other, I concluded that: Most of those stories about Queen Tehya are closer to superstition than to historical truth, and were recorded after about a century and a half of the historical incidents, and that their owners were not honest and objective Scientific, they drew their information about people who did not live with the event but transmitted it orally, and the purpose of their stories was to try to polish the image of the conquering Umayyad army and reduce the resistance of the Moroccan queen, especially as she managed to inflict heavy losses on Hassan’s army and forced him to retreat to Cyrenaica, Libya. More importantly, the latter did not bother to send reassuring messages to the queen explaining to her the noble mission that he came for, which is spreading Islam in the countries of the Maghreb, and then resistance to Hassan's death was not a rejection of the Islamic religion as much as it was in defense of the land and the homeland.
GEOTECHNOLOGIES AND THEIR APPROACHES IN GEOMORPHOLOGICAL STUDIES: CHALLENGES AND POSSIBILITIES BEYOND GEOGRAPHICAL INFORMATION SYSTEMS (GIS)
Authors: ARCHIMEDES PEREZ FILHO  , LUCA LÄMMLE  , VINÍCIUS BORGES MOREIRA
Published: January 2021

O conceito de Geotecnologia se consolidou associado a plataformas SIG’s, softwares de geoprocessamento e/ou processamento digital de imagens. Com o aperfeiçoamento e surgimento de novas técnicas nas últimas décadas devido a constantes avanços tecnológicos, essa limitação conceitual deve ser ampliada, compreendendo geotecnologias como o conjunto de técnicas utilizadas para obtenção de dados em determinado local geográfico, com o objetivo de processar e analisá-los em função de uma hipótese proposta. O objetivo do presente trabalho é abordar as diferentes possibilidades de uso das mesmas a partir de alguns exemplos, além de fomentar a abordagem das mesmas no âmbito da geomorfologia brasileira. O procedimento metodológico ocorreu em duas etapas, sendo a primeira revisão de literatura sobre exemplos de técnicas que podem ser consideradas geotecnologias; e a segunda, análise e quantificação de publicações em anais dos últimos 10 anos do Simpósio Nacional de Geomorfologia (SINAGEO), obtendo, assim, panorama a partir da maior base da dados de trabalhos na temática realizados no Brasil. Ressalta-se que o pesquisador deve considerar a escala de análise adotada para utilizar as Geotecnologias, uma vez que a utilização ou correlação equivocada pode comprometer os resultados e até invalidá-los. Este parece ser o caminho a seguir, sendo a Geografia, Geologia e Geomorfologia brasileira parte desse movimento, contribuindo para o avanço da ciência.
HBIM approach to implement the historical and constructive knowledge. The case of the Real Colegiata of San Isidoro (León, Spain)
Authors: Santoni Arianna , Martín-Talaverano Rafael , Quattrini Ramona , Murillo-Fragero José Ignacio
Published: January 2021

The development of Historic Building Information Modelling (HBIM) focuses (among other uses) on the adaptation of the BIM methodology to the historical building’s features, as well as on increasing geometric accuracy and on model data enrichment. Regarding the first issue, it can be underlined, on the one hand, that historical buildings are the result of a sequence of transformations that take place throughout their whole history; they cannot be considered as unitary objects that have been created in a single moment. Therefore, they have a temporal sequence which can be understood as the essence of their evolving nature. On the other hand, historical architecture has different construction materials and techniques, with other kinds of features and pathological processes that are quite different from those of contemporary buildings. In this line, this study proposes a new workflow that allows outlining new criteria that include both the temporal sequence and the constructive features of historical buildings. For this purpose, the case study of the Real Colegiata of San Isidoro in León (Spain) has been considered. In order to create the model, several modelling strategies have been used to compare both the results and the time spent in this task. Then, the model has been divided into several parts, both in terms of constructive criteria and temporal stratification, and thus, the database and the implemented information have been organized following such essential aspects of the historical building. Finally, to provide an advanced and more efficient use of the information, customized queries have been created using Dynamo, allowing searching with combined criteria and the isolation and visualization of the resulting elements. This could be helpful for both research and conservation and management activities.

Highlights:

A comparison of modelling strategies applied to historical buildings taking into consideration their singularities and estimation of required times and benefits.

The division and taxonomy of the model to incorporate both the temporal sequence and the constructive aspects, allowing enrichment of the HBIM model with customized parameters.

The development of queries generated in Dynamo to allow customized and combined searches of data, optimizing the use of the database.
Purposing aesthetics in historic preservation: advocating, signifying, and interpreting aesthetics
Authors: Elwazani Salim
Published: January 2021

Aesthetics is a pillar consideration in historic preservation. Yet, purposing aesthetics for historic preservation ends seems to lag behind the opportunities. Utterly subjective, aesthetics poses challenges for the preservation community worldwide to moderate, accommodate, and purpose aesthetics in heritage programs. The challenges revolve around the assessment of aesthetical purposing in three domains. These domains include the community disposition towards accommodating aesthetics (advocacy), the criteria and strategies for assessing the aesthetic value of historic resources (signification), and, the standards for treating historic resources in preservation projects (interpretation). This study, therefore, assesses the trends for purposing aesthetics in historic preservation thought and practice through three platforms: advocating aesthetics, signifying aesthetics, and interpreting aesthetics. The study completed literature content analysis on aesthetics in general and aesthetics in historic preservation in particular. Further, because of the perspective of the study, the works of international and country preservation programs provided information relevant to advocacy, signification, and interpretation of aesthetics that have been refined by classification, comparison, and exemplification methods. Among others, these works include those of the International Council on Monuments and Sites (ICOMOS) and the U.S. National Historic Preservation Program in the National Park Service. The study culminated with general and platform-specific conclusions. First, as the three proposed platforms (advocacy, signification, and interpretation) maintain structural and serial relationships, they constitute a relevant and feasible framework for assessing aesthetical purposing. Second, as the aesthetical purposing assessment followed a broad, international perspective, the conclusions of the study are commensurate with the selective scope of information used from international and country preservation programs. Third, the contribution to aesthetical purposing at each of the three platforms can be measure only in general, and at times, subjective terms.

Highlights:

Proposing aesthetical advocacy, aesthetical signification, and aesthetical interpretation as a platform framework to assess the purposing of aesthetics was feasible.

As aesthetical purposing was approached from a broad, international perspective, the conclusions of the study commensurate with the selective scope of information used.

The contribution to aesthetical purposing at each of the three platforms is hard to measure; however, the indications point to uneven contribution.
Antecedents and Mediating Role of Green Buying Behavior
Authors: Khalique Muhammad , Iftikhar Samra , Yaacob Mohd Rafi bin , Tahir Ahsan
Published: January 2021

Sustainability of the environment is one of the major issues both in developed and developing countries. There is an abundance of studies on green buying behavior. However, a few have studied the mediating role of green buying behavior. Thus, we have developed a new model that has five direct and three mediating relationships. This empirical research has used a snowball sampling technique for collecting the data. We distributed 400 questionnaires and received 377 valid responses. The study has used Smart PLS software for data analysis, including reliability, validity, and generating measurement and structural models. We found that green brands, green identification, and social influence are significant predictors of green buying behavior. Further, we find that the green brand image and green buying behavior promote green satisfaction. The results also suggest that green buying behavior mediates (1) green image and green satisfaction, (2) social influence and green buying behavior, (3) self-identification, and green satisfaction. We also found that consumers have a favorable attitude towards green buying behavior. However, there is a huge gap in consumers’ attitudes and actual buying behavior. Thus, marketers and practitioners need to develop strategies that would translate a favorable attitude toward actual buying behavior.
Antecedents of Attitude towards Advertising of Controversial Products in Digital Media
Authors: Yaseen Safeena , Saeed Syed Amir , Mazahir Muhammad Ibtesam , Chinnasamy Sara
Published: January 2021

The promotion of controversial products on digital media has become a challenge for marketers as consumers of different ethnicities and cultures access web media. Therefore, the study has examined the impact of advertising’s antecedents on consumers’ attitude and their effect on purchase intentions. The study has also considered the mediating roles of attitude towards purchase intentions. The population for this study comprises of adult female digital media users. We collected data from 400 female respondents via the online survey method. The results suggest that hedonic value, falsity, and materialism directly impact attitude towards the advertising of controversial products. Further, hedonic value and materialism also affect purchase intentions. We also found that advertising attitude mediates the relationship between hedonic value, falsity, materialism, and purchase intentions. The study’s empirical results will help design appropriate marketing strategies, especially in the context of controversial products. Future research may extend the model by incorporating other factors and testing their efficacy in different regions and cultures.
Unemployment: A Missing Link
Authors: Khan Muhammad Irfan , Iqbal Athar , Zaman Syed Imran , Wajidi Faraz
Published: January 2021

Developing countries like Pakistan face a host of economic problems in the form of stagnant exports, low economic growth, inadequate private investment, and inefficient utilization of foreign direct investment. Given these problems, we have examined macroeconomic factors impact on unemployment in Pakistan from 1967 to 2018. We also tested the proposed hypotheses through “VAR, fully modified least squares, and Granger causality tests.” Our results suggest that exports did not stimulate jobs in Pakistan. Perhaps, Pakistan needs to diversify its exports by focusing on non-conventional value-added goods. The results also indicate that although FDI and government expenditures have created jobs, they are below expectations. Although we found that private investment has helped job creation, the effect is small compared to other developing countries. Furthermore, we find that macroeconomic factors have had little impact on unemployment in the long run.
Emotional Intelligence and Teaching Satisfaction: The Mediating Role of Emotional Labor Strategies
Authors: Umer Amna , Arif Imtiaz , Ali Syed Ethesham
Published: January 2021

The study examines the direct effect of four “emotional intelligence” attributes on teachers’ job satisfaction in Karachi’s private teaching institutions. The study also investigates the mediating effects of “emotional labor strategies” on teachers’ job satisfaction. We have used the questionnaire adopted from earlier studies. We distributed 550 questionnaires to respondents, of which we received 499 useable responses. The study has used Smart PLS version 3.3 for data analysis. Our results support only six hypotheses, including two direct and our indirect. This study has contributed to the body of knowledge in the following ways. First, it has measured the effects of the four attributes of emotional intelligence on job satisfaction. Second, most studies have examined the mediating effect of emotional labor strategies on emotional intelligence and other job satisfaction antecedents. Perhaps this is the first study that has examined the direct impact of the sub-factor of emotional intelligence on teachers’ job satisfaction. Additionally, it also looks at the mediating effect of emotional labor strategies on teachers’ satisfaction. There are several implications for managers. For example, the teaching institutes should provide counseling and training to teachers for enhancing their emotional intelligence. Emotional labor strategies help individuals control and monitor their emotions; therefore, educational institutions may also encourage their teachers to adopt these strategies.
Organizational Performance and Entrepreneurial Orientation: The Intervening Role of Organizational Learning
Authors: Matloob Sheema , Hussain Shah Muzaffar , Shah Saeed Abbas , Jan Khan Muhammad Wasim
Published: January 2021

Many past studies have examined the association between entrepreneurial orientation (E.O.) and organizational performance (O.P.). However, these studies have not adequately addressed the mediating roles of acquisition learning (A.L.) and experiential learning (E.L.) on organizational performance. Given this gap, we have developed a new model that contains six direct relationships, three mediating relationships, and one multi-mediating relationship. The focus of the study was on Indonesian Pharmaceutical SMEs. We have collected a sample of 365 respondents non-randomly. For statistical analysis, we have used Smart PLS version 3.2. The statistical analysis includes reliability, validity, and descriptive statistics. The results confirm that acquisition learning (A.L.), experiential learning (E.L.), and entrepreneurial orientation (E.O.) promote organizational performance (O.P.). We also found that entrepreneurial orientation (E.O.) impacts acquisition learning (A.L.) and innovative performance (I.P.) but does not affect organizational performance (O.P.). However, the results suggest that acquisition learning (A.L.) and experiential learning (E.L.) are positively linked. Our results also support all the mediating relationships.
Decoding the Sino-North Korean Borderlands.docx
Authors: Cathcart Adam , Green Christopher , Denney Steven
Published: January 2021

Since the 1990s, the Chinese-North Korean border region has undergone a gradual transformation into a site of intensified cooperation, competition, and intrigue. These changes have prompted a significant volume of critical scholarship and media commentary across multiple languages and disciplines. Drawing on existing studies and new data, Decoding the Sino-North Korean Borderlands brings much of this literature into concert by pulling together a wide range of insight on the region's economics, security, social cohesion, and information flows. Drawing from multilingual sources and transnational scholarship, this volume is enhanced by the extensive fieldwork undertaken by the editors and contributors in their quests to decode the borderland. In doing so, the volume emphasizes the link between theory, methodology, and practice in the field of Area Studies and social science more broadly.
Valores de referencia de normalidad para la prueba del nivel de disconfort para la sensación de intensidad: resultados preliminares
Authors: Baraldi Knobel Keila Alessandra , Ganz Sanchez Tanit , Nizan Pfeilsticker Leopoldo , Stoller Guita
Published: January 2021

El Nivel de Disconfort para la Sensación de Intensidad (LDL - Loudness Disconfort Level) es una prueba audiológica utilizada para la selección del nivel de saturación de audífonos, y más recientemente también indicada para la evaluación auditiva de personas con acúfenos e hipersensibilidad auditiva. Creemos necesaria la investigación y la determinación de los valores de referencia de normalidad para el LDL en individuos sin pérdida de audición, dado que la hipersensibilidad auditiva puede darse en individuos con umbrales auditivos normales. Los niveles de disconfort para las frecuencias 0,5 a 8 KHz en los dos oídos fueron investigados en situación de test y retest en 51 individuos con edad entre 18 y 25 años y con  audición normal. La mediana para todas las frecuencias varió entre 92,5 y 100 dBNA, sin diferencias entre los oídos. Esta prueba mostró una alta variabilidad inter-sujetos y una alta consistencia entre test y retest. Concluimos que el LDL puede ser un buen instrumento para evaluar la evolución de pacientes con hipersensibilidad auditiva.