bluuebunny/crossref_metadata_2025 huggingface dataset:
Use of Basilic vein in arteriovenous fistulas construction for hemodialysis access. Is it a good option alternative to prosthetic arteriovenous grafts?
Authors: Abdo Ehab M. , Abouelgreed Tamer A. , Elshinawy Waleed E. , Farouk Nehal , Abdelaal Mohamed A. , Ismail Hassan , Ibrahim Amal H. , Kasem Samar A. , Aboomar Ahmed A.
Published: July 2023

Purpose: For patients with a failed forearm autogenous fistula (AF) and an exhausted cephalic vein, there is controversy about whether a brachial basilic AF with transposition or an arteriovenous prosthetic bridging graft (BG) must be the second vascular access option. This work measured and compared these two modalities according to patency rates, complications, and revisions. Patients and methods: A retrospective study of 104 cases that had either a brachial basilic AF (72) or an Arteriovenous BG (32). Technical success, operative complications, procedurerelated mortality, maturation time, functional primary, secondary, and overall patency rates were all assessed. Results: Technical success was obtained in all participants. No procedure-linked mortality. Maturation time for BGs was significantly shorter than AFs. The complication rate was significantly higher in BGs than in AFs. The most prevalent complication was access thrombosis. The functional primary patency rate was significantly higher in AF than in BG at 12-month followup: 77.7% vs 53.1% (p < 0.012). secondary patency rate was higher in AF than in BG at 1-year follow-up 62.5% vs 42.8% (p = 0.063), respectively. In addition, BGs required more interventions to preserve patency. Conclusions: AF had higher primary, secondary and overall functional patency rates and needed fewer procedures to keep patency than BGs. Cases that need early vascular access as a result of central venous catheter complications or who have a reduced life expectancy may benefit from BGs.
Effect of a new sustainable cooling system used during firming and brining on the microbiological, chemical, and sensory characteristics of buffalo mozzarella cheese
Authors: Di Paolo Marika , De Stefano Martina , Polizzi Giulia , Vuoso Valeria , Santoro Adriano Michele Luigi , Anastasio Aniello , Marrone Raffaele
Published: July 2023

The cooling applied during the firming and brining processes represents an important production step in mozzarella cheese making. The temperature fluctuations of the cooling water can negatively affect the hygiene, composition, and quality of mozzarella. Some sustainable cooling systems can minimize this problem by using hot process fluids as heat sources to generate refrigerated energy. This study aimed to evaluate the effects of a new cooling system equipped with a water-ammonia absorption chiller (MA) on the characteristics of buffalo mozzarella through a comparative study with products cooled by using a traditional ice water chiller (MT). The buffalo mozzarella cheese manufacture was monitored, and the samples were analyzed for chemical, nutritional, microbiological, and sensory characteristics. The MT samples showed an overall weight loss of 7.4% compared to an average of 2.8% for the MA samples. The MT samples were characterized by greater sapidity than the MA ones, which instead showed a higher moisture content that increased juiciness. The microbiological analysis showed a lower concentration of mesophilic bacterial load in the MA samples than the MT [difference of 1 Log (CFU/g)], probably due to the low and constant temperatures that reduced the permanence time of the mozzarella in the vats (firming and brining). This study represents a preliminary positive evaluation of the use of this sustainable cooling system for mozzarella cheese, which is useful for dairy plants with an annual cheese production volume sufficient to justify the operating cost of the plant and the annual energy cost.
Influence of 24-Week Yoga Intervention on Cardiovascular Risk Factors and Inflammatory Markers in Type 2 Diabetes
Authors: Sharma Sonali , Bhardwaj Sonal , Gupta Arvind , Katoch Vishwa Mohan , Sharma Krishna Kumar , Gupta Rajeev
Published: July 2023

Background and Aims:

Persistent hyperglycemia, dyslipidemia, inflammation, and oxidative stress are important in cardiovascular risk in type-2 diabetes mellitus (DM). To evaluate the effect of 24-week yoga intervention on anthropometry and biochemical markers in DM patients, we performed a study.

Methods:

A hospital-based prospective randomized study in 104 participants with DM divided into control (n = 52) and intervention (n = 52) groups was performed. Patients in the intervention group performed 40 min of multifaceted individualized yoga exercises 5 days/week for 24 weeks. Anthropometric measurements and biochemical analysis were performed at baseline and after 24 weeks in both groups. Descriptive statistics are reported.

Results:

Baseline characteristics were similar in both groups. At 24 weeks, participants in the intervention versus controls had lower body mass index (25.6 ± 2.9 vs. 28.0 ± 3.2 kg/m2), waist–hip ratio (0.94 ± 0.06 vs. 0.99 ± 0.05), systolic blood pressure (121.2 ± 11.7 vs. 139.3 ± 19.1 mmHg), fasting glucose (142.7 ± 45.3 vs. 175.7 ± 45.4 mg/dL), glycated hemoglobin (7.2 ± 1.8 vs. 9.4 ± 1.9%), low-density lipoprotein cholesterol (167.5 ± 38.1 vs. 192.2 ± 51.4 mg/dL), nonhigh-density lipoprotein cholesterol (136.8 ± 35.3 vs. 158.6 ± 47.2 mg/dL), interleukin-6 (32.0 ± 21.5 vs. 43.5 ± 34.3 pg/mL), and high-sensitivity C-reactive protein (5.1 ± 3.7 vs. 9.5 ± 15.6 mg/L) (P ≤ 0.05). In the intervention group, higher levels of high-density lipoprotein cholesterol (49.2 ± 15.0 vs. 40.4 ± 7.2 mg/dL) and serum total antioxidants (1.9 ± 0.4 vs. 1.4 ± 0.4 mmol/L) were observed (P < 0.001).

Conclusion:

A short-term yoga intervention led to reduced glycemia, dyslipidemia, and inflammatory markers and increased antioxidant status in patients with type-2 DM.
Interest in and Barriers to Practicing Yoga among Family Caregivers of People with Cancer
Authors: Desai Krupali , Applebaum Allison J. , Latte-Naor Shelly , Pendleton Eva M. , Cheyney Sarah , Li Qing S. , Bao Ting , Chimonas Susan , Mao Jun J.
Published: July 2023

Background:

Family caregivers of people with cancer report high levels of psychological distress. Yoga, with well-documented mental health benefits, could be a useful intervention to address distress in this population. However, little is known about yoga practices among cancer caregivers. The present study evaluates their interest in and barriers to yoga practice.

Methods:

We conducted a cross-sectional survey study of family caregivers of cancer patients at five suburban satellite locations of an academic cancer center. Survey items and statistical analyses focused on yoga usage as well as interest in and barriers to yoga practice.

Results:

Among 539 participants, most were females (64.8%), white (84.2%), and caring for a spouse or partner (54.7%). Interest in practicing yoga among study participants was 42.3%. Increased interest was independently associated with being females (odds ratio [OR] = 3.30, 95% confidence interval [CI] = 1.98–5.51, P < 0.001) and employed (part-time: OR = 2.58, 95% CI = 1.1–6.18, P = 0.03; full-time: OR = 1.77, 95% CI = 1.1–2.01, P = 0.02). Few participants (6.3%) were currently practicing yoga, although 31% had done so in the past. Sixty-one percent of those who had practiced before their loved one’s diagnosis stopped practicing yoga afterward. Commonly cited barriers to yoga practice included time constraints (37.3%) and psychological obstacles (33.6%). About a quarter of those who had never practiced yoga lacked awareness of yoga’s benefits (26.6%).

Conclusion:

Despite the low use of yoga, interest in practicing was moderately high, especially among women and employed caregivers. As caregivers face numerous barriers to yoga practice, strategies are needed to overcome these barriers and help them access yoga’s health benefits.
Intraocular Pressure Changes Following Three “Head below the Heart” Postures in Yoga Practitioners – A Prospective Observational Study
Authors: Swathi N. , Ramanathan Meena , Srikanth K. , Bhavanani Ananda Balayogi
Published: July 2023

Context:

Intraocular pressure (IOP) increases during “sirasasana” and may be a risk factor for the progression of glaucoma. Other “head below heart” asanas may also cause increase in IOP.

Aims:

To determine the change in IOP following three “head below the heart” postures-“meruasana”, “viparithakarni,” and “sarvangasana”.

Settings and Design:

Prospective observational study conducted in a tertiary care hospital over 3 weeks.

Materials and Methods:

Willing, regular yoga practitioners recruited by purposive sampling performed “meruasana”, “viparithakarni,” and “sarvangasana” in random order according to a 3 × 3 periods cross over study design after baseline measurement of IOP, blood pressure (BP), and pulse rate. Each asana was held for 30 s. Within 15–30 s of completion of asana, IOP, BP, and pulse rate were recorded. There was an interval of 30 min between the asanas.

Statistical Analysis Used:

Normality of data was tested using the Kolmogorov–Smirnov test. Repeated measures of ANOVA with Tukey-Kramer multiple comparisons was used to compare changes in IOP, BP, pulse rate following asana. P ≤ 0.05 was accepted as statistically significant.

Results:

There were 33 participants with a mean age of 29.6 ± 10.5 years (95% confidence interval [CI]: 26.02, 33.18). The mean baseline IOP was 15.5 ± 3.4 mm Hg (95% CI: 14.34, 16.66) in the right eye and 16.7 ± 3.4 mm Hg (95% CI: 15.54, 17.86) in the left eye. IOP showed a significant reduction following each of the three asanas (P < 0.0001). However, neither pulse rate (P = 0.53) nor BP (P = 0.27) showed any change following the asanas.

Conclusions:

“Meruasana,” “viparithakarni,” and “sarvangasana” when held for 30 s by healthy yoga practitioners resulted in post-asana drop in IOP with no significant change in pulse rate or BP.
Isolated Macrostomia with Bilateral Facial Cleft in a Preterm Neonate
Authors: Raghavendra Prashanth Ranya , Nair Sruthi , Haribalakrishna Anitha , Tekwani Revati Vishnukumar
Published: July 2023

Facial clefts are a rare presentation with defects of the orofacial region associated with abnormalities in the soft tissues and bones. This condition has a variable presentation, often leading to aesthetic problems and feeding difficulty that affect growth and nutrition. We describe a preterm neonate diagnosed with nonsyndromic Tessier type 7 isolated bilateral facial clefts. The evaluation revealed a macrostomia with soft tissue and skin involvement with normal musculature, maxillae, mandible, and other facial bones. Timely recognition and evaluation of this premature neonate aided in better management of this condition. Long-term follow-up remains essential as plastic surgery-guided cosmetic rehabilitation, feeding, and speech therapy assessment are required for a better quality of life.
Intravenous Sildenafil for the Treatment of Persistent Pulmonary Hypertension of the Newborn in a Resource-Limited Setting
Authors: Ramirez Mirta Noemi Mesquita , Acevedo Margarita Samudio , Sarubbi Olivia C. Cardozo , Carrera Dina C. , Cabral Pedro L. Villalba
Published: July 2023

Introduction:

Treatment of severe persistent pulmonary hypertension of the newborn (PPHN) is based on the administration of selective pulmonary vasodilators. Inhaled nitric oxide is the only vasodilator therapy approved by the Food and Drug Administration. Non-selective vasodilator such as sildenafil has been the treatment available administered orally in most developing countries to manage newborn with PPHN. The aim of the study was to describe the effects and tolerability of intravenous (IV) sildenafil, as a loading dose of 0.4 mg/kg, followed by a continuous infusion of 1.6 mg/kg for 72 h on the oxygenation index (OI) in neonates with PPHN.

Materials and Methods:

This was an exploratory observational prospective study. Newborns ≥35 weeks of gestational age, post-natal age ≤72 h, with PPHN and an OI ≥20 were included in the study. Sildenafil was administered intravenously as a loading dose of 0.4 mg/kg, followed by a continuous infusion of 1.6 mg/kg for 72 h. During the sildenafil infusion, monitoring of vital signs and respiratory parameters was performed. The data were analysed with the SPSS v21.

Results:

Twenty-five infants were included. A significant improvement (P = 0.01) of OI (at admission, median: 25 and interquartile range [IQR] = 8) was observed at the end of the loading dose (3 h) (18 IQR = 4) and at 72 h (7 IQR = 4). No serious adverse effects were observed. Before hospital discharge, seven patients died.

Conclusions:

IV sildenafil administered, in newborns with PPHN with an IO ≥20, improved oxygenation in most of the patients without serious side effects.
Blood Glucose Profile of Exclusively Breastfed Healthy Newborns in the First 24 H of Life at Obio Cottage Hospital, Rivers State
Authors: Chukwuma Chidiebere Adaku , Tabansi Petronilla N. , Opara Peace I.
Published: July 2023

Background:

Hypoglycemia is common among healthy babies in the hours following delivery, as part of their necessary adjustments needed to survive outside the uterus. Although this condition has been proven to be temporary and remits spontaneously, the use of prelacteal feeds is still common due to the false impression of low blood glucose levels in newborns who are thought to have not been breastfed adequately.

Objective:

The objectives were to proffer a profile of blood glucose levels for healthy newborns in the first 24 h of life and to document signs of hypoglycemia among newborns with low blood glucose levels.

Materials and Methods:

This was a longitudinal study conducted over 6 weeks among 240 exclusively breastfed, healthy newborns delivered at Obio Cottage Hospital. The Finetest glucometer was used to measure blood glucose at the bedside at birth, three, 12, and 24 h.

Results:

The newborns comprised 137 (57.1%) males and 103 (42.9%) females. One hundred and ninety (79.2%) babies were born by spontaneous vertex delivery (SVD) and 50 (20.8%) by elective cesarean section. One (0.4%) newborn, delivered by SVD had asymptomatic hypoglycemia with a blood glucose level of 2.1 mmol/L at 3 h of life. A repeat random blood glucose testing done after an additional feed was 3.5 mmol/L and remained normal throughout the study. The mean blood glucose profile for the study population were 4.48 ± 1.09, 3.68 ± 0.65, 3.71 ± 0.55, and 4.09 ± 0.51 mmol/L at birth, 3, 12, and 24 h of life, respectively.

Conclusion:

Healthy newborns have normal blood glucose profiles in the first 24 h of life.
Effect of Light-emitting Diode Phototherapy on Serum Electrolyte Levels in Neonates with Unconjugated Hyperbilirubinemia: A Prospective Single-center Study
Authors: Nazim Naadia , Gaur Bablu Kumar , Ahmad Fatima Afreen , Maini Baljeet , Singh Rupa Rajbhandari
Published: July 2023

Background:

Neonatal unconjugated hyperbilirubinemia (NUH) is one of the common morbidities found in the 1st week of life. Phototherapy has been found to be the safest of all the known treatments for neonatal jaundice. Light-emitting diode phototherapy does, however, have some side effects, just like any other therapeutic approach.

Objectives:

We aimed to study the effect of light-emitting diode phototherapy and their duration on the serum electrolyte (serum sodium, potassium, chloride, and calcium) levels in neonates with unconjugated hyperbilirubinemia (UH) and to study the effect of phototherapy modes on them.

Materials and Methods:

All stable icteric neonates, gestational age >35 weeks, who received phototherapy for UH were included in the study. A double-surface light-emitting diode phototherapy system (spectrum 430–470 nm) was used. These neonates were subjected to different phototherapy modes: normal and intensive. Total serum bilirubin and serum electrolytes were measured at the start and the end of phototherapy. Paired t-test, independent t-test, and Chi-square test were used for the comparisons.

Results:

A total of 100 neonates were admitted for phototherapy. The male: female ratio was 1.08:1. The mean birth weight, mean gestational age, mean age, and mean duration of phototherapy of jaundiced neonates were 2.50 ± 0.603 kg, 36.8 ± 2.04 weeks, 2.56 ± 1.05 days, and 29.34 ± 6.51 h, respectively. The mean Na, K, Cl, and Ca levels before phototherapy were 140.10 ± 14.88 meq/L, 4.51 ± 0.55 meq/L, 105.65 ± 6.53 meq/L, and 8.90 ± 0.55 mg/dl and after phototherapy were 139.62 ± 5.38 meq/L, 4.36 ± 0.48 meq/L, 103.89 ± 6.85 meq/L, and 8.33 ± 0.72 mg/dl, respectively (P < 0.001). The duration of phototherapy was found to correlate with serum Ca levels significantly negative (P < 0.05).

Conclusion:

This study shows that serum electrolyte levels were significantly decreased during light-emitting diode phototherapy. These levels were affected more by the duration of phototherapy than by its mode. Phototherapy-induced dyselectrolytemia is a significant concern, as electrolyte abnormalities result in severe short-term and long-term adverse effects.
Socket-Shield Technique – A New Method for Bone Preservation
Authors: Sethiya Kiran , Dhadse Prasad , Jaiswal Priyanka , Agrawal Diksha
Published: July 2023

ABSTRACT

Dental implants have become a standard treatment in the replacement of missing teeth. In periodontium following tooth extraction, the blood vessels are cutoff which leads to facial bone plate resorption as periodontal membrane primarily vascularizes the bundle bone of tooth. Therefore, in implant dentistry, it is important to preserve ridge following extraction as it may hinder positioning of implant and its outcome. However, ridge preservation possesses the biggest challenge, hence a new method in which there is deliberate retention of root to preserve bone was introduced. Socket-shield technique (SST) aims to avoid alterations of tissue following extraction, offers promising results, and reduces the need of bone grafting. This review article overviews the principles, indications, contraindications, advantages, disadvantages, surgical technique, classification, and clinical outcomes of previous studies in literature. Furthermore, this article gives a short overview on modification of SST and complications faced by clinicians in implant dentistry.
An appraisal of therapeutic potential of Darvyadi Leha and its components in light of pharmacological evidences
Authors: Rai Deepshikha , Garg Girraj Prasad
Published: July 2023

Introduction:

Darvyadi Leha is a classical Ayurveda formulation for Pandu Roga (anemia) described in Charak Samhita and Bhaishajya Ratnavali. Its ingredients include Daruharidra (Berberis aristata), Haritaki (Terminalia chebula), Vibhitaki (Terminalia bellirica), Amalki (Emblica officinalis), Shunthi (Zingiber officinalis), Pippali (Piper longum), Marich (Piper nigrum), Vidanga (Embelia ribes), and Ayoraj (Lauh bhasma). Avaleha dosage form is semisolid with thick consistency and will have the benefits of easy administration, better palatability, and longer shelf life.

Objectives:

To study the pharmacological evidences of Darvyadi Leha and its components.

Materials and Methods:

Research literature published in online journals of PubMed, Scopus, Google Scholar, DHARA, and Ayush Research Portal, was searched extensively. The keywords used were pharmacological evidence or study of Darvyadi Leha, Daruharidra (B. aristata), Haritaki (T. chebula), Vibhitaki (T. bellirica), Amalki (E. officinalis), Shunthi (Z. officinalis), Pippali (P. longum), Marich (P. nigrum), Vidanga (E. ribes) and Ayoraj (Lauh bhasma). Journals published online in last 20 years were considered. Ayurveda classical texts were also referred.

Observations:

The components of drug, Darvyadi Leha have shown several properties namely anti-oxidant, bio-availability enhancer, anti-tussive, hepatoprotective, anti-atherosclerosis, and anti-microbial activities in in vitro studies and animal trials. Clinical evidences show significant therapeutic effect of Darvyadi Leha on anemia.

Conclusion:

The drug, Darvyadi Leha has a promising therapeutic potential to be used as a Rasayana drug, an anti-infective agent and drug for iron deficiency anemia. The same needs to be further validated with larger, multicentric, standard controlled and randomized clinical trials.
Prevalence of dysmenorrhea and Ayurveda Treatment
Authors: Kapoorchand Hemalatha
Published: July 2023

Objective:

This study aimed to determine the prevalence of dysmenorrhea (Udavarta yonivyapad) in Indian population and the utilization of Ayurvedic practices. Furthermore, the study attempts to analyze the barriers to Ayurvedic health care access in Indian population.

Materials and Methods:

A cross-sectional online survey was done using a semistructured questionnaire with 40 questions on various aspects of dysmenorrhea and the utilization of Ayurvedic health services. From the responses of 310 respondents, 306 were included in the study. The Numeric Pain Rating Scale was used to gauge the intensity of pain. A descriptive analysis of the data collected was done, and the results were expressed as percentages.

Results:

The present study shows 75.16% prevalence of dysmenorrhea. Among the respondents with dysmenorrhea, over-the-counter usage of medicines was more prevalent in participants with mild dysmenorrhea, whereas professional consultation was sought with increased severity of pain. Many participants sought more than one treatment modality for pain relief. Those who got relief were 38.89% who sought allopathic treatment and 62.79% who sought Ayurvedic management.

Conclusion:

The number of participants seeking Ayurvedic professional was comparatively less with regard to the prevalence of dysmenorrhea. Even though Ayurvedic management is perceived to be effective in managing dysmenorrhea by those who opted, the number of participants who sought Ayurveda was less. Lack of awareness regarding Ayurvedic remedies for simple ailments such as dysmenorrhea and lack of reference system were the reasons for it. Awareness should be created regarding Ayurvedic management of dysmenorrhea and other ailments for safe and efficacious use of Ayurvedic health care system.
Independent predictors and clinical predictive score of postanesthetic reintubation after general anesthesia: A time-matched, case control study
Authors: Choovongkomol Chidchanok , Ariyanuchitkul Thidarat , Choovongkomol Kongtush , Tongjapo Vipanee
Published: July 2023

Background and Aims:

Postanesthetic reintubation is associated with increased morbidities and mortality; however, it can be reduced with defined predictors and using a score as a tool. This study aimed to identify independent predictors and develop a reliable predictive score.

Material and Methods:

A retrospective, time-matched, case control study was conducted on patients who underwent general anesthesia between October 2017 and September 2021. Using stepwise multivariable logistic regression analysis, predictors were determined and the predictive score was developed and validated.

Results:

Among 230 patients, 46 were in the reintubated group. Significant independent predictors included age >65 years (odds ratio [OR] 2.96 [95% confidence interval {CI} 1.23, 7.10]), the American Society of Anesthesiologists physical status III–IV (OR 6.60 [95%CI 2.50 17.41]), body mass index (BMI) ≥30 kg/m2 (OR 4.91 [95% CI 1.55, 15.51]), and head and neck surgery (OR 4.35 [95% CI 1.46, 12.87]). The predictive model was then developed with an area under the receiver operating characteristic curve (AUC) of 0.84 (95% CI 0.78, 0.90). This score ranged from 0 to 29 and was classified into three subcategories for clinical practicability, in which the positive predictive values were 6.01 (95% CI 2.63, 11.50) for low risk, 18.64 (95% CI 9.69, 30.91) for moderate risk, and 71.05 (95% CI 54.09, 84.58) for high risk.

Conclusion:

The independent predictors for postanesthetic reintubation according to this simplified risk-based scoring system designed to aid anesthesiologists before extubation were found to be advanced age, higher American Society of Anesthesiologists physical status, obesity, and head and neck surgery.
Effects of multigrain rice and white rice on periodontitis: an analysis using data from the Korea National Health and Nutrition Examination Survey 2012-2015
Authors: Ryu Seung-Hee , Wang Zi-lan , Kim Seon-Jip , Cho Hyun-Jae
Published: July 2023

OBJECTIVES: Numerous studies have investigated the efficacy of whole grains; however, research on multigrain remains limited. Grains exhibit combined positive effects against various diseases. The purpose of this study was to examine the impact of multigrain and white rice consumption on periodontitis.METHODS: We analyzed data from the Korea National Health and Nutrition Examination Survey V-3 and VI, collected between 2012 and 2015, which included 12,450 patients (4,859 male and 7,591 female) aged 19-64 years. The World Health Organization’s Community Periodontal Index (CPI) was utilized to assess the presence of periodontitis, with periodontitis defined as a CPI index score of ≥3. Multivariable logistic regression analysis was performed after adjusting for potential confounding variables.RESULTS: The group that consumed only multigrain rice was less likely to have periodontitis than the group that consumed only white rice (odds ratio [OR], 0.80; 95% confidence interval [CI], 0.69 to 0.93). When stratified by sex, the risk of periodontitis demonstrated a 24% decrease in female who consumed only multigrain rice (OR, 0.76; 95% CI, 0.62 to 0.93). A similar result was observed in the age group of 40-64 years (OR, 0.84; 95% CI, 0.71 to 0.99). In the diabetes stratification model, the normal group that consumed only multigrain rice exhibited a 25% decrease in the odds of periodontitis (OR, 0.75; 95% CI, 0.62 to 0.91).CONCLUSIONS: Our findings suggest that the prevalence of periodontitis may vary depending on the type of rice consumed.
Application of G-quadruplex targets in gastrointestinal cancers: Advancements, challenges and prospects
Authors: Han Zong-Qiang , Wen Li-Na
Published: July 2023

Esophageal cancer (EC) is one of the most common digestive system malignancies in the world. The combined modality treatment of EC is usually surgery and radiation therapy, however, its clinical efficacy for advanced patients is relatively limited. Ferroptosis, a new type of iron-dependent programmed cell death, is different from apoptosis, necrosis and autophagy. In recent years, many studies have further enlightened that ferroptosis plays an essential role in the occurrence, development and metastasis of tumors. Targeting ferroptosis stimulates a new direction for further exploration of oncologic treatment regimens. Furthermore, ferroptosis has a critical role in the immune microenvironment of tumors. This paper reviews the mechanism of ferroptosis and the ferroptosis research progress in the treatment of EC. We further elaborate the interaction between ferroptosis and immunotherapy, and the related mechanisms of ferroptosis participation in the immunotherapy of EC, so as to provide new directions and ideas for the treatment of EC.
Clinical value of serum pepsinogen in the diagnosis and treatment of gastric diseases
Authors: Qin Yuan , Geng Jia-Xin , Huang Biao
Published: July 2023

Esophageal cancer (EC) is one of the most common digestive system malignancies in the world. The combined modality treatment of EC is usually surgery and radiation therapy, however, its clinical efficacy for advanced patients is relatively limited. Ferroptosis, a new type of iron-dependent programmed cell death, is different from apoptosis, necrosis and autophagy. In recent years, many studies have further enlightened that ferroptosis plays an essential role in the occurrence, development and metastasis of tumors. Targeting ferroptosis stimulates a new direction for further exploration of oncologic treatment regimens. Furthermore, ferroptosis has a critical role in the immune microenvironment of tumors. This paper reviews the mechanism of ferroptosis and the ferroptosis research progress in the treatment of EC. We further elaborate the interaction between ferroptosis and immunotherapy, and the related mechanisms of ferroptosis participation in the immunotherapy of EC, so as to provide new directions and ideas for the treatment of EC.
Proteomics-based identification of proteins in tumor-derived exosomes as candidate biomarkers for colorectal cancer
Authors: Zhou Ge-Yu-Jia , Zhao Dong-Yan , Yin Teng-Fei , Wang Qian-Qian , Zhou Yuan-Chen , Yao Shu-Kun
Published: July 2023

Esophageal cancer (EC) is one of the most common digestive system malignancies in the world. The combined modality treatment of EC is usually surgery and radiation therapy, however, its clinical efficacy for advanced patients is relatively limited. Ferroptosis, a new type of iron-dependent programmed cell death, is different from apoptosis, necrosis and autophagy. In recent years, many studies have further enlightened that ferroptosis plays an essential role in the occurrence, development and metastasis of tumors. Targeting ferroptosis stimulates a new direction for further exploration of oncologic treatment regimens. Furthermore, ferroptosis has a critical role in the immune microenvironment of tumors. This paper reviews the mechanism of ferroptosis and the ferroptosis research progress in the treatment of EC. We further elaborate the interaction between ferroptosis and immunotherapy, and the related mechanisms of ferroptosis participation in the immunotherapy of EC, so as to provide new directions and ideas for the treatment of EC.
Candy cane syndrome: A systematic review
Authors: Rio-Tinto Ricardo , Canena Jorge , Devière Jacques
Published: July 2023

During endoscopy, an endoscopist is inevitably faced with the occasional “difficult colonoscopy,” in which the endoscopist finds it challenging to advance the endoscope to the cecum. Beyond optimization of technique, with minimized looping, minimal insufflation, sufficient sedation, and abdominal splinting when needed, sometimes additional tools may be needed. In this review, we cover available techniques and technologies to help navigate the difficult colonoscopy, including the ultrathin colonoscope, rigidizing overtube, balloon-assisted colonoscopy and the abdominal compression device.
Effect of phosphate on peroxymonosulfate activation: Kinetics, mechanism and implication to in-situ chemical oxidation for water decontamination
Authors: Tang Min , Huang Yulin , Tian Na , Nie Yulun
Published: July 2023

Peroxymonosulfate (PMS, HSO5-) is an increasingly popular oxidant for groundwater remediation via in situ chemical oxidation (ISCO). However, it is desired to evaluate the effect of phosphate on the PMS oxidation of organics in detail due to the saline characteristics of groundwater. In this study, ofloxacin (OFX) as a typical antibiotic was chosen as a model pollutant. The results indicated that 64% of OFX was degraded by PMS in the presence of HPO42- (PMS/HPO42- system), and the efficiency increased from 64% to 80% when the HPO42- concentration was increased from 0.1 mol/L to 0.3 mol/L. The corresponding pseudo-first-order reaction constants were 0.0086 and 0.02 min-1, respectively. In comparison, PO43- and H2PO4- showed almost no reactivity. Electron spin response (ESR) analysis and quenching tests proved that SO4·- and 1O2 were the main oxidizing species for OFX degradation in PMS/HPO42- system. Hence, HPO42- was the most effective form in PMS activation and its performance was highly pH and ionic strength sensitive. Given the ambient pH and phosphate concentration in saline groundwater, a considerable amount of HPO42- can be produced, which then serves as a homogeneous PMS activator in ISCO process. This finding provides new insights into ISCO process using PMS.
Coding Matrices for Wreath Products of Groups
Authors: Suleiman Enoch , Khammash Ahmed A.
Published: July 2023

Wreath product, a powerful construction in group theory, has found extensive applications in various areas of mathematics and computer science. In this paper, we present a comprehensive analysis of coding matrices associated with wreath products. The coding matrices for the wreath product of two cyclic finite groups were given for the first time. It gives a generalization of the coding matrices for the semi-direct product. We found out that the coding matrix of wreath product really has the same shape as the one for semidirect product and gave the RW-matrix for the coding matrix. An example was showed to illustrate the assertions. Conditions were also given for different wreath products of cyclic groups and that gives different orders for the wreath products.
Impact of Monetary Policy Transmission on the Demographic in India: A Structural VAR Approach
Authors: Jena Pabitra Kumar , Sharma Raghav , Dehury Tania , Nayak Sasmita
Published: July 2023

This study explores the relationship between monetary policy instruments and India’s demographic structure, to understand how these instruments interact with the population composition. To trace the relationship, this study has considered annual data from 1993-2018. Using the structural vector autoregression (VAR) with restrictions and considering various macroeconomic variables, the study shows a significant relationship between the monetary policy variable represented by the repo rate and the demographic structure represented by the working-age population. Overall, the study concludes that demographic shifts affect monetary policy effectiveness.
PERANCANGAN SISTEM INFORMASI PENJUALAN BERBASIS ANDROID PADA BUTIK ZAHARA HIJAB
Authors: Suriyanti Indah , Rosa Selvia , Rahmayani Mentari Tri Indah
Published: July 2023

Kemajuan teknologi sistem informasi telah menghasilkan dampak positif dalam bisnis, terutama pada sistem e-commerce berbasis web. Sistem e – commers berbasis web memungkinkan akses melalui perangkat komputer maupun smartphone, dengan antarmuka yang mudah digunakan. Sistem informasi ini memberikan keuntungan bagi pelaku bisnis untuk memantau transaksi penjualan, stok barang, dan laporan transaksi perusahaan. Oleh karena itu, setiap perusahaan perlu mengikuti perkembangan teknologi dengan mengimplementasikan sistem yang terkomputerisasi. Dalam penelitian ini, dirancang sebuah website penjualan online untuk Butik Zahara Hijab. Penggunaan website ini memperlihatkan profesionalitas dan kepercayaan bagi Butik Zahara Hijab serta meningkatkan keamanan dalam pengelolaan bisnis. Penelitian ini dibuat untuk mengatasi masalah pada sistem saat agar mempermudah transaksi penjualan antara pelanggan dan butik zahara hijab dengan rancangan sistem informasi berbasis DBMD (Database management System) dengan sistem aplikasi MYSQL dan bahasa pemograman PHP, dan metode usulan untuk pengembangan perangkat lunak System Development Life Cycle (SDLC) Waterfall. Sistem ini memiliki fitur-fitur seperti tampilan produk, penambahan produk, kategori, ukuran, pemesanan, dan laporan pembelian. Penelitian ini memberikan solusi efektif dan efisien bagi Butik Zahara Hijab dalam mengelola penjualan online. Secara keseluruhan fitur yang dirancang memenuhi kebutuhan butik zahara hijab.
PERANCANGAN SISTEM INFORMASI PERPUSTAKAN USTADZ MIL STAIN BENGKALIS
Authors: Restu Rio , Ramadhan Rizky , Rahmayani Mentari Tri Indah
Published: July 2023

Perpustakaan adalah salah satu institusi penting dalam dunia pendidikan dan pengembangan ilmu pengetahuan. Namun, pengelolaan perpustakaan yang efisien dan efektif sering kali menjadi tantangan bagi para pustakawan. Oleh karena itu, perancangan sistem informasi perpustakaan yang terintegrasi menjadi sangat penting untuk mempermudah proses pengelolaan dan akses informasi. Penelitian ini bertujuan untuk merancang sebuah sistem informasi perpustakaan yang komprehensif dan mudah digunakan. Metode yang digunakan dalam penelitian ini meliputi studi literatur, pengumpulan kebutuhan pengguna, analisis kebutuhan sistem, perancangan arsitektur sistem, dan implementasi prototipe. Sistem informasi perpustakaan yang di rancang mencakup beberapamodul penting, antara lain:Manajemen Koleksi, pencarian dan Peminjaman, Manajemen Anggota. Sistem informasi perpustakaan yang dihasilkan dari penelitian ini diharapkan dapat meningkatkan efisiensi dan efektivitas pengelolaan perpustakaan. Dengan adanya sistem ini, diharapkan akses informasi menjadi lebih cepat dan mudah bagi pengguna perpustakaan. Selain itu, pengelola perpustakaan juga akan mendapatkan manfaat dari kemampuan sistem untuk menghasilkan laporan dan statistik yang berguna dalam meningkatkan layanan perpustakaan. Penggunaan untuk metode pada sistem ini adalah memenggunakan metode pengembangan perangkat lunak System Development Life Cycle (SDLC) Waterfall.
ACTION RESEARCH IN THE FUNCTION OF ENCOURAGING READING HABITS IN STUDENTS: JOINT FAMILY AND SCHOOL ACTIVITIES
Authors: Milanović Nedeljko
Published: July 2023

Taking into account the relevance of action research, as well as their positive characteristics and the effects they can lead to, this article is aimed at encouraging and developing reading habits among students and visiting the school library through the application of action research. Motivated by the examples of good practice of many practitioners, as well as the exceptional methodological expertise and desire of the school actors (teachers and school librarians) with whom we collaborated on this research, we tried to promote reading activities and visits to the school library through cooperation and the unique action of students, teachers, and parents through a spectrum of creative contents. The findings of the conducted action research show a number of achieved results in the positive aspect of building reading habits among students, attitude towards reading and activities in the direction of visiting the school library. Many research projects and activities are directed towards the promotion of reading, where further research could direct more attention to the active involvement of parents in the activities of the school library, providing opportunities and opportunities for parents to express their ideas in this sphere, creating conditions for their participation and applying action research to develop values and reading habits in students.
El desarrollo de la tesis
Authors:   Universidad ESAN, Arbaiza Fermini Lydia
Published: July 2023

Existe abundante literatura referida al método de investigación científica y sus aspectos teóricos y metodológicos; sin embargo, son pocos los textos acerca de esta materia que logran establecer una comunicación fluida y cercana con sus lectores, para ofrecerles una ruta sencilla con que llevar a cabo una investigación de calidad y asumir el estimulante reto de elaborar una tesis académica. El desarrollo de una tesis es una publicación que logra extensamente este objetivo. Ha sido escrita pensando en aquellos estudiantes universitarios de pregrado y posgrado, quienes se encuentran en la etapa fundamental de elaborar una investigación y escribir una tesis. Se trata de una guía que recoge las nociones básicas del método de investigación, con el fin de orientar a sus lectores a través de los diversos procesos involucrados en la investigación académica y, fruto de ello, elaborar una tesis de calidad, bien fundamentada y redactada, en cualquier campo del saber. Con un lenguaje sencillo y riguroso en cuanto a su contenido, la autora introduce las bases metodológicas de la investigación científica y recomienda constantemente dos ingredientes esenciales para lograr la tesis aprobada: una fuerte motivación y confianza en el método y en la relevancia del quehacer científico para nuestras sociedades, y las actitudes éticas y profesionales de excelencia que son imprescindibles en el ejercicio académico.
SEVERAL ASPECTS OF THE ADAPTATION METHODOLOGY OF MOTOR-CONVEYOR TRANSPORT AND DEVELOPING MINING SYSTEM ON AN OPEN PIT
Authors:   nstitute of Mining of the Ural Branch of the Russian Academy of Sciences, GLEBOV ANDREY
Published: July 2023

The study of the processes of mutual adaptation of the motor-conveyor transport system and the pit mining system developing with increasing depth in order to control the mutual correspondence of these systems is an urgent scientific problem, the solution of which is aimed at developing the theory of the formation of transport systems, which allows to increase the efficiency of the use of motor-conveyor transport in the development of deep-lying ore deposits of minerals.
DEVELOPMENT OF A DIGITAL GAS ECOSYSTEM ON THE BASIS OF A COMPREHENSIVE SCIENTIFIC AND TECHNICAL PROGRAM OF A FULL INNOVATIVE CYCLE
Authors:   Gubkin Russian State University of Oil and Gas (National Research University), DMITRIEVSKY ANATOLY , EREMIN NIKOLAY ,   Gubkin Russian State University of Oil and Gas (National Research University), STOLYAROV VLADIMIR ,   NTS PJSC Gazprom, CHERNIKOV ALEXANDER ,   Institute of Oil and Gas Problems of the Russian Academy of Sciences (IPNG RAS)
Published: July 2023

The article considers the formation of a digital gas ecosystem based on platform solutions and integrated scientific and technical programs and projects of a full innovation cycle. The article reveals modern aspects of the creation and implementation of digital gas production technologies. The issues of digital modernization of gas production in the context of reducing the carbon footprint are outlined. The main problems in the implementation of digital modernization of the gas industry are identified: an acute shortage of personnel with digital competencies in the field of gas production, including specialists in opticalization, multi-sensorization, supercomputing, cybersecurity and petrorobotics. The humanitarian aspects of the introduction of strong artificial intelligence systems and petrorobotics of gas production are emphasized, in particular, the issues of retraining engineering and technical personnel for new digital specialties. It was revealed that in the gas industry, in the context of reducing the carbon footprint, it is planned to use fiber optic technologies, multi-sensor monitoring of gas production, digital twins of gas facilities, and hybrid artificial intelligence in decisionmaking.
EVOLUTION OF THE DIGITAL OIL AND GAS ECOSYSTEM FROM SUPERCOMPUTING TO METACOMPUTING
Authors:   Institute of Oil and Gas Problems of the Russian Academy of Sciences (IPNG RAS), EREMIN NIKOLAY ,   Gubkin Russian State University of Oil and Gas (National Research University)
Published: July 2023

The subject of the study is the consideration of trends in the evolution of the digital oil and gas ecosystem from supercomputing to metacomputing. The key factor constraining the innovative development of the Russian oil and gas complex is the lack of high-performance computing systems. The key oil and gas tasks requiring the involvement of super- and metacomputing of the peta and exaflop performance levels (1015 and 1018 floatingpoint operations per second, respectively) include the tasks of managing the "digital twin" of the oil and gas complex as a whole, the world's largest West Siberian oil and gas production center and unique oil and gas real-time monitoring of oil and gas fields, and training of highly qualified oil and gas specialists in this field.
ON THE POSSIBILITIES OF APPLYING ARTIFICIAL INTELLIGENCE METHODS IN SOLVING OIL AND GAS PROBLEMS
Authors:   Institute of Oil and Gas Problems of the Russian Academy of Sciences (IPNG RAS), EREMIN NIKOLAY ,   Gubkin Russian State University of Oil and Gas (National Research University), SELENGINSKY DMITRY ,   Institute of Oil and Gas Problems of the Russian Academy of Sciences (IPNG RAS)
Published: July 2023

The subject of research in the article is the application of artificial intelligence methods in oil and sas vroduction. In the oil and sas industry, the introduction of artificial intelligence methods increases the efficiency and productivity of the technologies used. This delivers better results, making AI tools an important technology for the industry. This article discusses the introduction of artificial intelligence methods for effective planning, prevention of complications and emergencies, determining the properties of the reservoir rock, optimizing drilling and production capacity. With accurate knowledge ofpermeability and porosity, engineers can develop a reservoir plan and effectively manage hydrocarbon recovery. AI-based models use log data and seismic data to predict porosity. The permeability prediction is derived by considering different types of well log data in AI prediction modeling. Artificial intelligence methods, which can be trained by the accumulated database from real experiments, computer simulations and logs from operating fields, have the ability to predict the occurrence of complications and emergencies. Artificial intelligence tools can help optimize production, improve production efficiency and recover hydrocarbons.
CALCULATION OF THE SCREW CONVEYOR OF THE MIXED GROUND SHIELD TUNNEL BORING MACHINES
Authors:   Tula State University, ZHABIN ALEKSANDR , MERZLYAKOV VIKTOR ,   Tula State University, CHEBOTAREV PAVEL ,   Tula State University, SARYCHEV VLADIMIR ,   Tula State University
Published: July 2023

The issues of calculation of structural and kinematic parameters, as well as power indicators of work in the design of screw conveyors of the mixed ground shield tunnel boring machines
ANALYSIS OF THE ENERGY CHARACTERISTICS OF THE GRINDING DEPARTMENT OF THE CONCENTRATION FACTORY
Authors:   Moscow Polytechnic University, KLYUEV ROMAN , BOSIKOV IGOR ,   orth Caucasian Institute of mining and metallurgy, GAVRINA OKSANA ,   orth Caucasian Institute of mining and metallurgy, ZATSEPIN EVGENIY ,   Lipetsk State Technical University
Published: July 2023

For processing plants of mining and processing plants, an important and urgent issue is a comprehensive analysis of the energy characteristics of the most energy-intensive equipment. Such an analysis is necessary to identify the potential for energy savings and reduce energy costs per product cost. In the presented work, on the basis of data on the power consumption of a large processing plant, an analysis of the energy characteristics of autogenous grinding mills was carried out. Based on the data on the power consumption of the processing plant departments, statistical estimates were obtained: average (estimation of the mathematical expectation); standard (unbiased estimate of standard deviation). The technological process of grinding separation is given, the regime map of the technological process of the self-grinding body is shown. The utilization factors for active power, the forms of the load schedule, the filling of the load schedule are determined. The dynamics of change in the power value during the hours of the evening maximum of the power system over the decades of the month under study is given...
IMPRO VEMENT OF EXPL OSIVE PREPARATION OF THE EXCAVATION BLOCK OF FRACTURED ROCKS FOR
Authors:   Tula State University, SAFRONOV VIKTOR , SARYCHEV VLADIMIR , ZAYTSEV YURI ,   Tula State University, SAFRONOV VADIM ,   «GEOTIMS» LLC
Published: July 2023

Crushing of the rock mass of the excavation block is mainly influenced by macrocracking, which determines the divisibility of rocks into natural ones. The dimensions of the natural separations of the extraction block are determined by the values of the parameters of the macro crack systems. In practice, it is quite common to encounter conditions where natural individual extraction blocks satisfy processes in size in all sections of the pit-DSE process chain and only one or two layers with separations that need to be crushed. Using the principle of "no fraction by explosion of nothing superfluous, " a controlled interscreen crushing scheme with a certain location of downhole charges within a large-block rock layer is proposed.
DETERMINATION OF THE STRENGTH PROPERTIES OF LAYERED SPECIMENS PRODUCED BY THE METHOD OF SOLID FILLING
Authors:   Mining Institute of the Ural Branch of the Russian Academy of Sciences, UDARTSEV ARTEM , ASANOV ARSENIY ,   Perm National Research Polytechnic University
Published: July 2023

The article presents the results of laboratory studies to determine the strensth properties of layered samples under uniaxial compression, made from a sand-cement mixture by the "solid pouring" method.