bluuebunny/crossref_metadata_2025 huggingface dataset:
Tert-butylhydroquinone attenuates osteoarthritis by protecting chondrocytes and inhibiting macrophage polarization
Authors: Zhang Hua , Li Jie , Xiang Xiaobing , Zhou Bengen , Zhao Changqing , Wei Qiushi , Sun Youqiang , Chen Jianfa , Lai Boyong , Luo Zequan , Li Aihua
Published: November 2021

Aims

Tert-butylhydroquinone (tBHQ) has been identified as an inhibitor of oxidative stress-induced injury and apoptosis in human neural stem cells. However, the role of tBHQ in osteoarthritis (OA) is unclear. This study was carried out to investigate the role of tBHQ in OA.

Methods

OA animal model was induced by destabilization of the medial meniscus (DMM). Different concentrations of tBHQ (25 and 50 mg/kg) were intraperitoneally injected in ten-week-old female mice. Chondrocytes were isolated from articular cartilage of mice and treated with 5 ng/ml lipopolysaccharide (LPS) or 10 ng/ml interleukin 1 beta (IL-1β) for 24 hours, and then treated with different concentrations of tBHQ (10, 20, and 40 μM) for 12 hours. The expression levels of malondialdehyde (MDA) and superoxide dismutase (SOD) in blood were measured. The expression levels of interleukin 6 (IL-6), IL-1β, and tumour necrosis factor alpha (TNF-α) leptin in plasma were measured using enzyme-linked immunoabsorbent assay (ELISA) kits. The expression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and mitogen-activated protein kinase (MAPK) signalling pathway proteins, and macrophage repolarization-related markers, were detected by western blot.

Results

Tert-butylhydroquinone significantly attenuated cartilage destruction in DMM-induced mice in vivo. It demonstrated clear evidence of inhibiting IL-1β-induced chondrocyte apoptosis, inflammation, and differentiation defect in vitro. Meanwhile, tBHQ inhibited LPS-induced activation of NF-κB and MAPK signalling pathways, and also inhibited LPS-induced reactive oxygen species production and macrophages repolarization in vitro.

Conclusion

Taken together, tBHQ might be a potential therapeutic strategy for protecting against OA development. Cite this article: Bone Joint Res 2021;10(11):704–713.
The return of the labour process: race, skill and technology in South African labour studies
Authors: Kenny Bridget , Webster Edward
Published: November 2021

From its beginnings, the sociology of work in South Africa has been preoccupied with three enduring themes: skill/deskilling, racism in the workplace, and Fordism/racial Fordism. With the advent of democracy in the 1990s there was a shift away from studying the labour process. We argue in this article that there has been a return to taking seriously the ways new forms of work in this postcolonial context pose new questions to the global study of work. A central preoccupation in the study of work has been the racialised reinscription of post-apartheid workplace orders, now in the context of new dynamics of externalisation and casualisation of employment. Another important theme is the shift away from studies of the formal sector workplace and toward the broader implications of the precarianisation and informalisation of labour. This focus coincided with the growth of new social movements by mostly unemployed (black) township residents around state services provision. This includes studies on working-class politics more broadly, with attention focusing on questions of organising and mobilising. More recently this interest in precarious labour has grown into studies of the gig economy, returning to earlier themes of technology and skill, as well as new forms of waged labour and wagelessness. We argue for the ongoing salience of labour process studies for understanding the specific issues of the securing and obscuring of value, and through the articulations of ‘racial capitalism’ offered by the long tradition of labour studies in South Africa.
Subcontracted racial capitalism: the interrelationship of race and production in meat processing plants
Authors: Piro Valeria , Sacchetto Devi
Published: November 2021

The aim of this paper is to extend discussion on subcontracted labour by focussing on the labour process and on the role of race and racialization within it. The existing literature has so far analysed the factors that have encouraged employer decisions to outsource labour, together with its effects on labour conditions and on industrial relations. Missing, however, has been any detailed analysis of the role of race and racialization processes, pivotal elements in the facilitation of subcontracting thereby accelerating the worsening of labour conditions.

Based on qualitative empirical research on the meat industry in Northern Italy, this article highlights how the processes of outsourcing and racialization intersect to support the segmentation of labour within the workplace. In particular, we argue that, through contracting out work to racialized groups of migrant workers, outsourcing has been both facilitated and legitimized. Furthermore, the presence of in-plant contractors has fostered the implementation of racializing practices, which in turn have bolstered workforce fragmentation on racial lines.

Notwithstanding this, our findings show that race can be a factor in the mobilization of subcontracted migrant labour through the production of pragmatic (racial) solidarities. These informal ties are a key component in the development of the everyday struggles and alliances that emerge within grass roots worker organisations as well as beyond their boundaries through hybrid forms of collective organisation.
Organised by transitions: the self-organisation of next-generation welfare professionals in Slovenia
Authors: Samaluk Barbara , Greer Ian
Published: November 2021

Much is known about innovative union strategies to organise young workers, but little is known about how and why they self-organise outside of unions. Based on field research in Slovenia, we examine ‘next-generation welfare professionals’, a diverse group of students, unemployed graduates and precarious workers attempting to enter state-regulated, and relatively well unionised education and social protection professions. We argue that their self-organisation is a direct consequence of their precarious education-to-work transitions and consequent disembeddedness from the workplace and professional community. Their grievances stem from a mismatch between strict professional entry requirements and scarce paid internships, which lead to long unemployment spells, unsupportive active labour market schemes, and a fear of social exclusion. Their initial tactic was to establish communities from which a collective sense of injustices and self-organising emerged and they targeted policymakers with demands for sustainable government funded internships. Although their relations with established trade unions are not close, they do receive organisational support from the Trade Union Youth Plus that organises students, the unemployed and precarious graduates stuck in a transitional stage of ‘waithood’. Our findings show the need for unions to become more present within transitional zones that, are shaped by state policies.
Low cross talk homogeneous seven-core five-LP mode fiber based on a high and low refractive index double ring
Authors: Wang Luyao , Li Shuguang , Meng Xiaojian , Guo Ying , Li Zenghui
Published: November 2021

We propose a what we believe is a novel, to the best of our knowledge, high and low refractive index double-ring (HL-DR) structure in few-mode multicore fibers (FM-MCFs) to simultaneously suppress intercore cross talk (XT) and intermodal cross talk. The fabrication methods of HL-DR seven-core fiber are introduced. A series of intercore XT values are calculated by the average power coupling coefficient, which shows that the HL-DR structure has a great contribution to meet the intercore XT target of less than

−

30

d
B

/

100

k
m

in FM-MCFs. Intermodal XT is mainly measured by the effective refractive index difference (

Δ

n

e
f
f

) between modes, and the

Δ

n

e
f
f

between any two adjacent modes is larger than

2

×

1

0

−
3

. Other main fiber properties, including bending loss and dispersion, are also simulated by the finite-element method. The results imply that the bending loss can satisfy the requirement of five-LP mode operation over the C 

+

 L band. In addition, the dispersion comparison of

L
P

01

mode illustrates that the fiber dispersion performance is not significantly influenced by the addition of the HL-DR structure. Through numerical analyses, an optimal HL-DR seven-core five-LP mode fiber with low XT is obtained, and it has a relative core multiplicity factor (RCMF) of 62.17. The proposed structure targets the design and application of space division multiplexing fibers with high capacity and independent channels.
Formulation of resonant optical force based on the microscopic structure of chiral molecules
Authors: Horai Takao , Eguchi Hiroki , Iida Takuya , Ishihara Hajime
Published: November 2021

Optical manipulation, exemplified by Ashkin’s optical tweezers, is a promising technique in the fields of bioscience and chemistry, as it enables the non-destructive and non-contact selective transport or manipulation of small particles. To realize the separation of chiral molecules, several researchers have reported on the use of light and discussed feasibility of selection. Although the separation of micrometer-sized chiral molecules has been experimentally demonstrated, the separation of nanometer-sized chiral molecules, which are considerably smaller than the wavelength of light, remains challenging. Therefore, we formulated an optical force under electronic resonance to enhance the optical force and enable selective manipulation. In particular, we incorporated the microscopic structures of molecular dipoles into the nonlocal optical response theory. The analytical expression of optical force could clarify the mechanism of selection exertion of the resonant optical force on chiral molecules. Furthermore, we quantitatively evaluated the light intensity and light exposure time required to separate a single molecule in a solvent. The results can facilitate the design of future schemes for the selective optical manipulation of chiral molecules.
Nonlinear optical properties of human cornea measured by spectral domain Z-scan method
Authors: Zeng Xi , Qi Pengfei , Li Mengdi , Cheng Zhenzhou , Lin Lie , Liu Weiwei , Wang Yan , Zhang Nan
Published: November 2021

In the myopia correction surgery by femtosecond laser, such as Laser in Situ Keratomileusis (LASIK) and Small Incision Lenticule Extraction (SMILE), the nonlinear refractive index of the cornea may cause the deviation of cutting depth. In order to improve the cornea cutting’s accuracy and reduce the possibility of undercorrection, the nonlinear refractive index coefficient n2 of the human cornea must be measured with high accuracy. The spectral domain Z-scan technique can measure n2 of the highly scattering biological tissues with much better signal to noise ratio and thus better accuracy than the conventional methods. In this paper, the n2 coefficient of one ex-vivo human corneal sample was measured by the spectral domain Z-scan technique. Experimental results show that as this corneal sample gradually dehydrates, its n2 coefficients are 1.1 ± 0.1×10−19 m2/W, 1.4 ± 0.2×10−19 m2/W and 1.6 ± 0.2 ×10−19 m2/W respectively for the corneal sample with water contents of 89%, 82%, and 78%. The increase of the water content reduces the value of n2, which is reasonable since the nonlinear refractive index coefficient of water is one order of magnitude smaller than that of the cornea.
Optical design of an Offner coded aperture snapshot spectral imaging system based on dual-DMDs in the mid-wave infrared band
Authors: Zhao Yushi , He Wenjun , Liu Zhiying , Fu Yuegang
Published: November 2021

With the advantages of flexible encoding and high frame rate, the digital micromirror devices (DMD) have been used as a binary encoding mask in the coded aperture snapshot spectral imaging (CASSI) systems. But the use of DMD will cause the image plane to tilt at a specific angle, so it is almost impossible to realize the strict matching between the optical system of CASSI and the cold stop of the infrared focal plane array in the mid-wave infrared band. In this paper, a CASSI system with two DMDs based on the Offner spectrometer is proposed to solve the above problem. The concept and working principle are described in detail. Under the premise of the matching optical parameters, the telescopic system, Offner spectroscopic system and microscopic system are designed independently. Then the integrated optimization design method is adopted, and the aberration of the microscopic system is used to offset the astigmatic aberration of the Offner spectroscopic system, and the imaging quality of the system is improved. The results of performance measurements confirm that the system has desirable spatial resolution and spectral response functions. Thus, the concept and optical design of the proposed system are verified to be effective and valuable.
Parents’ perceived knowledge and beliefs on congenital malformations and their causes in the Amhara region, Ethiopia. A qualitative study
Authors: Taye Molla
Published: November 2021

Introduction

Knowledge and beliefs of people on congenital malformations and their causes differ from society to society. As a result, there is a paucity of understanding community perceived knowledge and beliefs towards congenital malformations and their risk factors among children’s parents. Therefore, I sought to identify perceived knowledge and beliefs of parents on congenital malformations and their causes.

Methods

An in-depth discussion and interview were carried out on purposively selected forty participants (women and men) in the Amhara region, Ethiopia. The data were collected from June to July, 2015. Semi-structured guiding topics/questions were used during the discussions and in-depth interviews. Note and audio records were taken while the participants discussed the topics. After the discussions and in-depth interviews were completed, the transcripts were read repeatedly to understand the participant’s words, phrases, ideas, and concepts. Then notes were taken to combine pieces of similar transcripts. I have employed thematic framework analysis. The relevant transcripts were scrutinized, labeled and coded manually based on their relevance to the objective of the study. Then the coded transcripts were determined and categorized according to the type of thematic variables.

Results

The participants responded on three aspects of lived experience, perceived knowledge and beliefs on congenital malformations and their causes. Nearly half of the participants’ beliefs on the causes of congenital malformations were related to sin, contraceptive pills, un-prescribed drugs/medication use, and fertilizers (that is eating crops grown by using fertilizers). Almost all said that raising a child with a major congenital malformation was very difficult. About half of the participants’ belief on congenital malformations were traditional and resulted from poor awareness.

Conclusion

The findings of the present study highlight the challenges and impacts of congenital malformations on parents who had children with and without congenital malformation. Lived experience, perceived knowledge and beliefs of children parents on congenital malformation and their causes can be helpful information for designing preventive actions. Hence, planning a preventive strategy and providing health education on congenital malformations and their causes for children parents are very necessary.
A remote sensing-based survey of archaeological/heritage sites near Kandahar, Afghanistan through publicly available satellite imagery
Authors: Karaucak Mehmet , Steiniger Daniel , Boroffka Nikolaus
Published: November 2021

Due to its conflict-ridden recent history, it has been difficult to launch major archaeological projects and advanced field research in Afghanistan during the last forty years. Lately, the proliferation of remote sensing methods, especially the increasing availability of satellite imagery, has allowed generating a much-needed impetus for documentation and monitoring of the heritage in Afghanistan. In this study, we present novel site data obtained through an examination of publicly available satellite imagery in the southwestern region of Kandahar. The sites presented here consist of a multitude of cultural heritage such as settlement mounds, architectural remains, religious monuments, fortresses, and traditional water management systems. We also discuss the advantages, as well as the drawbacks of remote sensing surveys for archaeological research in Afghanistan, and share our data to be employed in further research and cultural heritage management in the region.
Self-medication practices to prevent or manage COVID-19: A systematic review
Authors: Quincho-Lopez Alvaro , Benites-Ibarra Christeam A. , Hilario-Gomez Maryori M. , Quijano-Escate Renatta , Taype-Rondan Alvaro
Published: November 2021

Background

Previous studies have assessed the prevalence and characteristics of self-medication in COVID-19. However, no systematic review has summarized their findings.

Objective

We conducted a systematic review to assess the prevalence of self-medication to prevent or manage COVID-19.

Methods

We used different keywords and searched studies published in PubMed, Scopus, Web of Science, Embase, two preprint repositories, Google, and Google Scholar. We included studies that reported original data and assessed self-medication to prevent or manage COVID-19. The risk of bias was assessed using the Newcastle–Ottawa Scale (NOS) modified for cross-sectional studies.

Results

We identified eight studies, all studies were cross-sectional, and only one detailed the question used to assess self-medication. The recall period was heterogeneous across studies. Of the eight studies, seven assessed self-medication without focusing on a specific symptom: four performed in the general population (self-medication prevalence ranged between <4% to 88.3%) and three in specific populations (range: 33.9% to 51.3%). In these seven studies, the most used medications varied widely, including antibiotics, chloroquine or hydroxychloroquine, acetaminophen, vitamins or supplements, ivermectin, and ibuprofen. The last study only assessed self-medication for fever due to COVID-19. Most studies had a risk of bias in the “representativeness of the sample” and “assessment of outcome” items of the NOS.

Conclusions

Studies that assessed self-medication for COVID-19 found heterogeneous results regarding self-medication prevalence and medications used. More well-designed and adequately reported studies are warranted to assess this topic.
Dietary acrylamide and physical performance tests: A cross-sectional analysis
Authors: Veronese Nicola , Dominguez Ligia J. , Ragusa Saverio , Solimando Luisa , Smith Lee , Bolzetta Francesco , Maggi Stefania , Barbagallo Mario
Published: November 2021

Background

Dietary acrylamide is found in certain foods, such as deep frying, baking and roasting, and is associated with higher inflammatory and oxidative stress parameters. The association between dietary acrylamide and physical performance has not yet been explored. The aim of the study was to investigate the relationship between dietary acrylamide intake and physical performance tests in a large cohort of North American individuals affected by knee osteoarthritis or at high risk for this condition.

Methods

Dietary acrylamide intake was obtained through a food frequency questionnaire and reported in quartiles and as an increase in deciles. Physical performance was explored using the 20-meter usual pace test, the 400-meter walking distance, and the chair stands time. The association between dietary acrylamide and physical performance tests was explored using linear regression analysis, adjusted for potential confounders.

Results

4,436 participants (2,578 women, mean age: 61.3) were enrolled. People in the highest quartile of dietary acrylamide reported significantly longer 20-meter walking (15.53±3.32 vs. 15.15±2.91 s), 400-meter walking (312±54 vs. 305±58 s) and chair stands (11.36±4.08 vs. 10.67±3.50 s) times than their counterparts in Q1. In adjusted linear regression analyses, each increase in one decile in dietary acrylamide was associated with a longer time in walking for 20 meters (beta = 0.032; 95%CI: 0.016–0.048; p = 0.04), 400 meters (beta = 0.048; 95%CI: 0.033–0.063; p = 0.002) and chair stands (beta = 0.016; 95%CI: 0.005–0.037; p = 0.04) times.

Conclusion

Higher dietary acrylamide intake was significantly associated with poor physical performance, also after accounting for potential confounders, suggesting a role for this food contaminant as a possible risk factor for sarcopenia.
Music and low-frequency vibrations for the treatment of chronic musculoskeletal pain in elderly: A pilot study
Authors: Eshuis Thom A. H. , Stuijt Peter J. C. , Timmerman Hans , Nielsen Peter Michael L. , Wolff André Paul , Soer Remko
Published: November 2021

Background

Transcutaneous vagal nerve stimulation has analgesic potential and might be elicited by abdominally administered low-frequency vibrations. The objective was to study the safety and effect of a combination of music and abdominally administered low-frequency vibrations on pain intensity in elderly patients with chronic musculoskeletal pain.

Methods

This trial was an international multicenter, randomized controlled pilot study. Patients at age ≥ 65 years with musculoskeletal pain for ≥ 3 months and a daily pain score ≥ 4 out of 10 were recruited at three centers. They were randomized to receive either a combination of music and low-frequency (20–100 Hz) vibrations administered to the abdomen, or a combination with the same music but with higher frequency (200–300 Hz) vibrations administered to the abdomen. Low-frequency vibrations were expected to result in pain reduction measured with a numeric pain rating scale (NRS). Patients in both groups received eight treatments of the music combined with the vibrations in three weeks. Primary outcomes were safety (Serious Adverse Events) and pain intensity measured at baseline, after the last treatment and at six weeks follow-up. Multilevel linear model analyses were performed to study group and time effects.

Results

A total of 45 patients were analyzed according to intention-to-treat principle. After 344 treatments, 1 Adverse Event was found related to the intervention, while 13 Adverse Events were possibly related. A multilevel linear model showed that the interaction effect of group by time did not predict pain intensity (F[1, 45.93] = 0.002, p = 0.97) when comparing pain intensity at baseline, after the last treatment and at follow-up.

Conclusions

The combination of music and abdominally administered vibrations was found to be safe and well tolerated by the elderly patients. However, over time, neither the low-frequency treatment group nor the high-frequency treatment group provided clinically meaningful pain relief. There is no evidence that the low-frequency treatment elicited vagal nerve stimulation.

Trial registration

The trial was prospectively registered in the Netherlands Trial Register (NTR: NL7606) on 21-03-2019.
Feed intake, nutrient digestibility, and selected rumen parameters in feedlot bulls fed diets with different feed additives
Authors: Silva Breno de Castro , Pacheco Marcos Vinicius Carneiro , Godoi Letícia Artuzo , de Souza Gilyard Angelo Pinheiro , Trópia Nathália Veloso , Pucetti Pauliane , Silva Flávia Adriane de Sales , Menezes Ana Clara Baião , Rennó Luciana Navajas , Paulino Mário Fonseca , Schoonmaker Jon Patrick , Valadares Filho Sebastião de Campos
Published: November 2021

An experiment was conducted to evaluate the feed intake, nutrient digestibility and selected rumen parameters in feedlot bulls fed diets containing different feed additives. Six rumen-cannulated Nellore bulls (age = 8 ± 1.0 months; initial BW = 225 ± 13.2 kg) were distributed in a 6 × 6 Latin square design. Six experimental diets based on 30% corn silage and 70% concentrate on a dry matter (DM) basis were evaluated. Diets differed in feed additive on a DM basis, as follows: 1.4% bicarbonate and magnesium oxide in 3:1 ratio (BOX); 36 ppm lasalocid sodium (LAS); 30 ppm monensin sodium (MON); 25 ppm virginiamycin (VIR); 30 ppm monensin sodium plus 25 ppm virginiamycin (MV); and 3.15% commercial mineral supplement containing D-limonene and exogenous α-amylase (EOA). The experiment lasted 144 d, with six periods of 24 d. Each period consisted of 14 d for dietary adaptation, 3 d for feces and urine collection, and 7 d for omasal and ruminal digesta collection. Bulls fed the BOX diet showed greater (P < 0.05) intake of DM, organic matter (OM), neutral detergent fiber (apNDF), crude protein (CP), and starch compared to the other diets. Diets with LAS, MON, VIR, MV, or EOA did not influence (P > 0.05) the DM, OM, apNDF, CP, or starch intake of feedlot bulls. Bulls fed the EOA diet showed greater (trend; P = 0.09) ruminal digestibility of starch compared to the other diets. The feed additives did not affect (P > 0.05) the intestinal or total tract digestibility of starch, rumen pH, microbial efficiency, total rumen fluid, dilution rate, rate of intake, rate of degradation, or passage rate of the DM, OM, apNDF, and starch. In conclusion, LAS, MON, VIR, MV, and EOA diets reduced nutrient intake compared to BOX. Although all feed additives presented similar effects on rumen pH, temperature, and kinetics the presence of exogenous α-amylase in the EOA diet may increase ruminal starch digestibility and apparent total tract digestibility of DM and OM.
Compensation incentives and heat exposure affect farm worker effort
Authors: Pan Qianyao , Sumner Daniel A. , Mitchell Diane C. , Schenker Marc
Published: November 2021

Farm workers are exposed to high risk of heat-related illness, especially when their jobs require working outside at a fast pace during hot days. Climate change has increased the number of days with high temperatures, and thereby the amount of time that farm workers are likely exposed to extreme heat. To better understand how high heat exposure affects farm workers, this study investigates how crop workers respond to heat exposure and estimates the effects of different pay and work arrangements on workers’ responses to heat exposure. We explore, specifically, whether piece-rate arrangements increase workers’ effort during periods with high heat exposure compared to workers paid by hourly wages. We use observational data from detailed measurements of localized heat exposure and individual workers’ effort in the field. First, these results show workers adjust their effort in response to heat exposure when the heat exposure level changes. Second, piece-rate arrangements increase workers’ effort during work shifts. Third, piece-rate arrangements allow workers to modify their effort more easily during different heat exposure levels. When facing low levels of heat exposure, workers who were paid by piece-rate arrangements exert a higher effort than workers paid by hourly wages, up until WBGT is 26.6˚C. When facing high levels of heat exposure (with WBGT exceeding 29.6˚C), workers paid by piece-rate arrangements lower their effort compared to workers paid by hourly wage arrangements.
Critical reappraisal of neoadjuvant concurrent chemoradiotherapy for treatment of locally advanced colon cancer
Authors: Chen Yen-Cheng , Tsai Hsiang-Lin , Li Ching-Chun , Huang Ching-Wen , Chang Tsung-Kun , Su Wei-Chih , Chen Po-Jung , Yin Tzu-Chieh , Huang Chun-Ming , Wang Jaw-Yuan
Published: November 2021

Background

Locally advanced colon cancer (LACC) is associated with surgical challenges during R0 resection, increased postoperative complications, and unfavorable treatment outcomes. Neoadjuvant concurrent chemoradiotherapy followed by surgical resection is an effective treatment strategy that can increase the complete surgical resection rate and improve the patient survival rate. This study investigated the efficacy and toxicity of concurrent chemoradiotherapy in patients with LACC as well as the prognosis and long-term clinical outcomes of these patients.

Materials

From January 2012 to July 2020, we retrospectively reviewed the real-world data of 75 patients with LACC who received neoadjuvant concurrent chemoradiotherapy. The chemotherapy regimen consisted of folinic acid, 5-fluorouracil, and oxaliplatin (FOLFOX). The following data were obtained from medical records: patients’ characteristics, pathologic results, toxicity, and long-term oncologic outcome.

Results

Of the 75 patients, 13 (17.3%) had pathologic complete responses. Hematologic adverse effects were the most common (grade 1 anemia: 80.0% and leukopenia: 82.7%). Conversely, grade 2 or 3 adverse effects were relatively uncommon (<10%). Pathologic N downstaging, ypT0, and pathologic complete responses were significant prognostic factors for patient survival. Multivariate analysis revealed that pathologic N downstaging was an independent predictor of patients’ overall survival (P = 0.019). The estimated 5-year overall and disease-free survival rates were 68.6% and 50.6%, and the medians of overall and disease-free survival periods were 72.3 and 58.7 months, respectively. Moreover, patients with pathologic complete responses had improved overall survival (P = 0.039) and an improved local recurrence control rate (P = 0.042) but an unfavorable distant metastasis control rate (P = 0.666) in the long-term follow-up.

Conclusion

The long-term oncologic outcome of patients with LACC following concurrent chemoradiotherapy is acceptable, and the adverse effects seem to be tolerable. Pathologic N downstaging was an independent prognostic factor for patients’ overall survival. However, a large prospective, randomized control study is required to confirm the current results.
Assessing the introduction risk of vector-borne animal diseases for the Netherlands using MINTRISK: A Model for INTegrated RISK assessment
Authors: de Vos Clazien J. , Hennen Wil H. G. J. , van Roermund Herman J. W. , Dhollander Sofie , Fischer Egil A. J. , de Koeijer Aline A.
Published: November 2021

To evaluate and compare the risk of emerging vector-borne diseases (VBDs), a Model for INTegrated RISK assessment, MINTRISK, was developed to assess the introduction risk of VBDs for new regions in an objective, transparent and repeatable manner. MINTRISK is a web-based calculation tool, that provides semi-quantitative risk scores that can be used for prioritization purposes. Input into MINTRISK is entered by answering questions regarding entry, transmission, establishment, spread, persistence and impact of a selected VBD. Answers can be chosen from qualitative answer categories with accompanying quantitative explanation to ensure consistent answering. The quantitative information is subsequently used as input for the model calculations to estimate the risk for each individual step in the model and for the summarizing output values (rate of introduction; epidemic size; overall risk). The risk assessor can indicate his uncertainty on each answer, and this is accounted for by Monte Carlo simulation. MINTRISK was used to assess the risk of four VBDs (African horse sickness, epizootic haemorrhagic disease, Rift Valley fever, and West Nile fever) for the Netherlands with the aim to prioritise these diseases for preparedness. Results indicated that the overall risk estimate was very high for all evaluated diseases but epizootic haemorrhagic disease. Uncertainty intervals were, however, wide limiting the options for ranking of the diseases. Risk profiles of the VBDs differed. Whereas all diseases were estimated to have a very high economic impact once introduced, the estimated introduction rates differed from low for Rift Valley fever and epizootic haemorrhagic disease to moderate for African horse sickness and very high for West Nile fever. Entry of infected mosquitoes on board of aircraft was deemed the most likely route of introduction for West Nile fever into the Netherlands, followed by entry of infected migratory birds.
Remote delivery of alcohol and/or substance misuse interventions for adults: A systematic review protocol
Authors: Howlett Neil , Garcia-Iglesias Jaime , Breslin Gavin , Bartington Suzanne , Jones Julia , Brown Katherine , Wills Wendy
Published: November 2021

Introduction

Alcohol and substance misuse are a public health priority. The World Health Organisation (WHO) estimates that harmful alcohol use accounts for 5.1% of the global burden of disease and that 35.6 million people worldwide are affected by substance misuse. The Coronavirus Disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has disrupted delivery of face-to-face alcohol and substance misuse interventions and has forced the development of alternative remote interventions or adaptation to existing ones. Although existing research on remote interventions suggests they might be as effective as face-to-face delivery, there has been a lack of systematic exploration of their content, the experience of service users, and their effectiveness for behavioural outcomes. This review will provide a narrative synthesis of the behaviour change techniques (BCT) contained in interventions for alcohol and/or substance misuse and their association with effectiveness.

Methods and analysis

Systematic searches will be conducted in MEDLINE, Scopus, PsycINFO (ProQuest), and the Cochrane Library. Included studies will be those reporting remote interventions focusing on alcohol and/or substance misuse among adults living in the community and which have a primary behaviour change outcome (i.e., alcohol levels consumed). Data extraction will be conducted by one author and moderated by a second, and risk of bias and behaviour change technique (BCT) coding will be conducted by two authors independently. A narrative synthesis will be undertaken focussing upon the association of BCTs with intervention effectiveness using promise ratios.

Patient and Public Involvement (PPI)

The Public Involvement in Research Group (PIRG), part of the NIHR-funded PHIRST, will be involved in refining the review questions, eligibility criteria, data synthesis and dissemination.

Dissemination

Dissemination will be through an academic peer reviewed publication, alongside other outputs to be shared with non-academic policy, professional, and public audiences, including local authorities, service users and community organisations.
A Tale from Constantinople: The History of a Film that Never Was, Bo Florin and Patrick Vonderau (2019)
Authors: Ksenofontova Alexandra
Published: November 2021

Review of: A Tale from Constantinople: The History of a Film that Never Was, Bo Florin and Patrick Vonderau (2019)

Höör: Brutus Östlings Bokförlag Symposion, 248 pp.,

ISBN 978-9-18748-341-7, p/bk, SEK 200 (approx. $24)
Emergence levels of pine shoot beetles from roundwood piles of Scots pine and the cascading damage in the surrounding forests
Authors: Melin Markus , Ylioja Tiina , Aarnio Leena , Hamunen Katri , Nevalainen Seppo , Pouttu Antti , Viiri Heli
Published: November 2021

Bark beetles are amongst the most aggressive pest agents of coniferous forests. Due to this, many boreal countries have designated laws aiming to lower the risk of bark beetle epidemics. Finlandâs forest legislation has pre-emptive measures targeted against bark beetles, and for Scots pine ( L.), the law concerns pine shoot beetles ( spp.). This study used data collected around 25 piles of Scots pine roundwood that were harvested in the winter but left in the forest until the following November. Thus, the pine shoot beetles were able to use the piles for breeding. We assessed the number of emerged insects from the piles and the cascading damage they caused in the surrounding forests. All roundwood piles, regardless of their volume, were used by the beetles for breeding. Highest densities of beetle exit holes were found from the parts of the log with thick and intact bark. If the bark of the log was damaged by the harvester head, the number of beetles decreased significantly. Depending on the volume of the roundwood pile, the cascading damage (fallen shoots) was noticeable up to ca. 40â60 m from the roundwood pile. Storing of piles smaller than 50 m did not cause excess damage. The number of fallen shoots per tree was generally below the known thresholds for when growth losses can occur. However, the study was conducted in mature forests, and it can be assumed that the recorded damage levels would severely affect the growth of young pines, raising the question of where to store the roundwood. As with other bark beetles, the role of beetles as damage agents may change in the future, but based on this as well as past studies, the species can be viewed as a notable damage agents only around long-term wood storage sites in the current northern conditions.Pinus sylvestrisTomicus3Tomicus
B-VITAMIN THERAPY FOR KIDNEY TRANSPLANT RECIPIENTS LOWERS HOMOCYSTEINE AND IMPROVES SELECTIVE COGNITIVE OUTCOMES IN THE RANDOMIZED FAVORIT ANCILLARY COGNITIVE TRIAL
Authors: Scott T.M. , Rogers G. , Weiner D.E. , Livingston K. , Selhub J. , Jacques P.F. , Rosenberg I.H. , Troen A.M.
Published: November 2021

Background: Objectives: Elevated plasma total homocysteine (tHcy) is associated with increased risk of cardiovascular disease, stroke and dementia. Results of clinical trials using B-vitamins to reduce the cognitive risks attributed to tHcy have been inconsistent. The high prevalence of both hyperhomocysteinemia and cognitive impairment among kidney transplant recipients makes them an important population in which to evaluate the effect of lowering homocysteine on cognitive function. We therefore evaluated whether B-vitamin therapy to lower tHcy would prevent cognitive-decline in a cohort of stable kidney transplant recipients. Design: The study was a longitudinal ancillary of the FAVORIT trial, a randomized, placebo-controlled multi-site trial of high-dose B vitamins to reduce cardiovascular and cerebrovascular events in clinically stable kidney transplant recipients with elevated tHcy. Participants: 584 participants from 18 sites across North America. Intervention: The intervention consisted of a daily multivitamin containing high-doses of folate (5.0 mg), vitamin B12 (1.0 mg) and vitamin B6 (50 mg). The placebo consisted of a daily multi-vitamin containing no folate and recommended daily allowances of vitamins B12 and B6 (0 mg folate; 2.0 µg vitamin B12; 1.4 mg vitamin B6). Measurements: Annual neuropsychological assessment for up to 5 years (mean 3.3 years) using a standardized test battery. Efficacy was analyzed on an intention-to-treat basis using end-of-trial data. Subgroup analyses included stratification for baseline plasma B-vitamin and tHcy concentrations. Results: At baseline, cognitive impairment was common with 61% of participants falling more than one standard deviation below published norms for at least one cognitive test. Fewer than 1% of participants had insufficient plasma folate < 5 ng/ml or vitamin B12 < 148 pmol/L. However, 44.6% had plasma B6 concentrations < 30 nmol/L. At follow-up, processing speed and memory scores were modestly but significantly better in the B-vitamin supplement group than in controls (p≤0.05). There was no interaction between baseline tHcy, B-vitamin status and treatment on the cognitive outcomes. Conclusions: High-dose B-vitamin supplementation provided modest cognitive benefit for kidney transplant recipients with elevated baseline tHcy. Since nearly all participants were folate and vitamin B12 sufficient at baseline, the potential cognitive benefits of folate and B12 supplementation in individuals with poor B-vitamin status remains to be determined.
EVALUATION OF THE NEUROPROTECTIVE POTENTIAL OF N-ACETYLCYSTEINE FOR PREVENTION AND TREATMENT OF COGNITIVE AGING AND DEMENTIA
Authors: Hara Y. , Fillit H.M. , Dacks P.A. , McKeehan N.
Published: November 2021

Alzheimer’s disease is a progressive neurodegenerative disease for which there is no cure and only a few treatments providing little relief. Increased oxidative stress that is associated with aging is strongly implicated in the pathogenesis and progression of Alzheimer’s disease. Studies have shown that levels of the endogenous antioxidant glutathione decline at an early stage of Alzheimer’s disease with decreased levels correlating with worse cognitive functions. N-acetylcysteine, a drug also widely available as a dietary supplement, is a precursor of L-cysteine, which in turn is a component of glutathione. Because cysteine availability is a limiting factor for glutathione synthesis, treatment with N-acetylcysteine may increase glutathione levels and thereby counter oxidative stress, promote redox -regulated cell signaling, and improve immune responses. In this review, we evaluate the existing literature and the potential of N-acetylcysteine in promoting cognitive health and alleviating cognitive decline associated with dementia. Discussion will also include possible mechanisms of action of N-acetylcysteine, its effects on aging biology, and safety of long-term use. Based on the available literature, a nutraceutical formulation containing N-acetylcysteine among other compounds has shown some pro-cognitive benefits in Alzheimer’s patients and older adults, but the evidence for N-acetylcysteine alone is less robust. Although N-acetylcysteine crosses the blood-brain-barrier, low bioavailability is an obstacle. One promising avenue of research may be to explore derivatives of N-acetylcysteine such as N-acetylcysteine amide, which has been reported in preclinical studies to have higher permeability through cellular and mitochondrial membranes with increased central nervous system bioavailability compared to N-acetylcysteine.
OBJECTIVE COGNITIVE IMPAIRMENT AND PROGRESSION TO DEMENTIA IN WOMEN: THE PROSPECTIVE EPIDEMIOLOGICAL RISK FACTOR STUDY
Authors: Skov Neergaard J. , Dragsbæk K. , Christiansen C. , Asser Karsdal M. , Brix S. , Henriksen K.
Published: November 2021

Background: Identification of subjects with a progressive disease phenotype is an urgent need in the pharmaceutical industry where most of the recent clinical trials in Alzheimer’s disease have failed. Objectives: The objective of this study was to identify subgroups of individuals with objective cognitive impairment (OCI), who were most likely to progress to dementia and to identify the risk factors associated with progression. Design: Prospective cohort study. Setting: Population-based. Participants: 5,380 elderly women from Denmark. Measurements: The Short Blessed Test and a category fluency test with animal naming, was used to assess cognitive function, and to classify them into different groups of OCI. Results: OCI was identified in 852 subjects at baseline. The risk of dementia was elevated for OCI subjects as compared to subjects with normal cognition (HR 1.46[1.19-1.79]). The courses of OCI were studied in a sub-cohort who completed the cognitive assessment at both the baseline and the follow-up visit (n = 1,933). Of these subjects 203 had OCI at baseline. The multi-domain subtypes of OCI were associated with progressive OCI. Subjects most likely to progress were older, physically inactive, had a higher level of total cholesterol (>6.5 mmol/L) and had a history of depression as compared to subjects with a non-progressive course of OCI. Conclusions: In this cohort we identified a risk profile associated with progression from OCI in older women. The degree of impairment at baseline was an important predictor of conversion to dementia, additionally several modifiable risk factors were associated with progression.
Sinodalidad eclesial
Authors: González Faus José Ignacio
Published: November 2021

Sinodalidad significa caminar juntos. Si la Iglesia es comunión en el ser lo ha de ser también en el obrar. Pero que algo sea imprescindible no significa que sea más fácil. El artículo examina las dificultades y los peligros que pueden acechar a la indispensable solidaridad eclesial, y busca criterios de discernimiento para afrontar esas dificultades, echando mano de ejemplos preclaros de la misma historia de la Iglesia. Porque, como dijo el cardenal Carlos Aguiar, se trata de que “nos pongamos a la escucha de todo el pueblo de Dios, sin excluir a nadie”.
Enseñanza-aprendizaje de programación de computadoras: avances en la última década
Authors: Ibarra-Zapata Ronald-Eduardo , Castillo-Cornelio José-Orlando , Trujillo-Natividad Pedro-Crisologo , García-Villegas Christian , Yanac-Montesino Rannoverng , Pando Brian
Published: November 2021

La programación de computadoras es una actividad muy demandada a nivel mundial en los últimos años como parte del desarrollo de software. La formación en esta área se da desde los niveles básicos de la educación. Según las publicaciones revisadas existen muchos trabajos a nivel básico y superior, como técnicas, metodologías, herramientas para apoyar el proceso de enseñanza-aprendizaje. A pesar de esto es necesario continuar con los aportes al tema. El objetivo de este trabajo es identificar los artefactos propuestos para la enseñanza-aprendizaje de programación de computadoras mediante un mapeo sistemático de literatura durante el periodo 2010-2020. Los resultados muestran la existencia de esfuerzos por proponer y validar metodologías y estrategias para la enseñanza a nivel de cursos, dejando abiertas oportunidades de investigación sobre guías, herramientas y métodos de evaluación para acompañar este proceso.
High Capacity Reversible Steganography on CMY and HSI Color Images Using Image Interpolation
Authors: Shahi D. , Kumar R.S. Vinod , Reshma V.K.
Published: November 2021

Steganography using image interpolation has created a new research area in multimedia communication. A reversible data concealing in HSI and CMY color models using image interpolation is proposed in this paper. The HSI and CMY image models are interpolated using High Capacity Reversible Steganography (CRS) technique. The median plane of both HSI and CMY color models are selected for secret message bit concealing. The secret message bits are concealed in the cover plane by Exclusive OR (XOR) operation. Since the cover image is recovered after secret message bit retrieval, this finds application in military and medical imaging applications. The experimental results of proposed scheme showed very high embedding capacity of about 16 bits in each pixel location of calculated pixel value, good image quality with a surface similarity index measure (SSIM) value 1 and high PSNR. Also, high robustness is achieved on comparing with the existing works.
The Impact of the Covid-19 Pandemic on the Vietnamese Economy: A Comprehensive Assessment based on Data Analysis and Surveys
Authors: Nguyen Hoang Phuong , Bui Viet Duc
Published: November 2021

For mankind, war always brings heavy devastation to people and property. In general, pandemic diseases are a factor causing mass death and much greater socio-economic devastation than war. Updating current news and analysis and synthesis initially shows that globalization has made the Covid-19 pandemic spread rapidly worldwide, unprecedented in history. At the same time, the Covid-19 pandemic had a strong impact on people's lives. This study aims to project the impact scenarios of the Covid-19 pandemic on the Vietnamese economy and provide some policy recommendations to limit negative economic impacts. The results of the study indicate that: (i) Q2 GDP growth of Vietnam is forecast to be around 2.0% over the same period and will even decline if a bad scenario occurs; (ii) If the pandemic is prolonged, the impact on the economy in general and the business sector, in particular, will be very serious. We recommend the government build a variety of economic policy scenarios ranging from short (support) to long term (rescue) to cope with the pandemic situation in Vietnam and other countries worldwide. The proposed policy solutions need to consider the delay in the issuance and implementation process to ensure timeliness and efficiency.