bluuebunny/crossref_metadata_2025 huggingface dataset:
Notificações de violência física, violência sexual, violência psicológica e negligência praticadas contra crianças no Brasil, 2011-2019: estudo ecológico de série temporal
Authors: Sartori Letícia Regina Morello , Oliveira Kaila Andressa dos Santos , Moura Kailany Freitas , Soares Pâmela de Oliveira , Matos Valéria Valério Garcia , Karam Sarah Arangurem
Published: November 2023

RESUMO Objetivo Descrever a tendência temporal das notificações de violência física, violência sexual, violência psicológica e negligência praticadas contra crianças no Brasil, entre 2011 e 2019. Métodos Estudo ecológico de série temporal, sobre notificações de violência contra crianças de 0 a 9 anos no Sistema de Informação de Agravos de Notificação. Taxas de notificação ajustadas por idade foram calculadas para Brasil, macrorregiões nacionais e sexo. Analisou-se a tendência das taxas por regressão joinpoint. Resultados Foram analisadas 88.820 notificações de violência física, 87.141 de violência sexual, 52.359 de violência psicológica e 166.664 notificações de negligência. Identificouse tendência crescente de notificações de violência física, sexual, psicológica e negligência, para o Brasil e ambos os sexos. Negligência apresentou a maior taxa [95,24 notificações/100 mil crianças (2019)]. Nordeste e Sudeste apresentaram tendência crescente para todas as violências. Conclusão Notificações de violência física, sexual, psicológica e negligência contra crianças apresentaram tendência crescente no Brasil, no período.
Extraction of Tooth Cusps based on DBSCAN Density Clustering and Neighborhood Search Algorithm
Authors: Yang Wanjie , Zhu Zhengyun , Zhou Ming , Li Dan , Zhang Jintao , Qin Maoyuan , Liu Baolong
Published: November 2023

A good tooth cusp extraction is helpful in evaluating the effect of cosmetic dental work in virtual tooth surgery. We propose a new tooth cusp extraction, which integrates the DBSCAN (density-based spatial clustering of applications with noise) clustering algorithm with the neighborhood search algorithm to extract tooth cusp from a three-dimensional cloud-point tooth model. This method used the point cloud height and curvature to screen out the dented point set. Then we employ the DBSCAN clustering algorithm to segment different feature regions of the tooth surface and generate the candidate point set. Finally, the candidate point set was accurately located at the tooth apex through the neighborhood search algorithm and the traversal search method of non-maximum suppression. The experimental results show that the proposed method is superior to the traditional watershed algorithm-based methods by calculating the recall rate and accuracy rate, and also has higher extraction speed and extraction precision than manual extraction methods.
Ohjausalan ammattilaisten osaamiskuvaukset : arviointilomakkeet
Authors: Kettunen Jaana , Vuorinen Raimo , Kasurinen Helena , Kukkaneva Eelis , Ruusuvirta-Uuksulainen Outi
Published: November 2023

Liittyy julkaisuun: Vuorinen, R., Kasurinen, H., Kettunen, J., Kukkaneva, E. & Ruusuvirta-Uuksulainen, O. (2023). Ohjausalan ammattilaisten osaamiskuvaukset : ehdotus kansalliseksi osaamiskehykseksi. Koulutuksen tutkimuslaitos, Raportteja ja työpapereita.4. Jyväskylän yliopisto, Koulutuksen tutkimuslaitos. URN: URN:ISBN:978-951-39-9815-8
FOREIGN POLICY EXPERTISE: THE RESEARCH POTENTIAL OF THE SECURITIZATION THEORY
Authors:   Donetsk State University, Onopko O. V.
Published: November 2023

The article is a scientific review of the studies of securitization theory, aimed at identifying its possible application to the study of foreign policy expertise. The study characterizes the main actors of securitization of international political issues; highlights the key provisions of securitization theory, which can be used to study foreign policy expertise; offers the author's interpretation of O. Khvostunova's typology of political experts regarding securitization in the framework of expert geopolitical discourse. The findings show that the application of securitization theory can contribute to the development of the scientific notion of foreign policy expertise as a specific network of experts engaged in the geopolitical discourse of the state and influencing foreign policy through it. It happens by having an effect on the geopolitical view of the world of both the political elite and the masses. In the future, the study of securitization steps and securitizing speeches in general can contribute to a deeper understanding of how and on what basis perceptions of foreign policy of decision makers in the security field are formed, what channels are used for this purpose, what role foreign policy expertise and pseudo-expertise play in this process.
ORGANIZATIONAL CULTURE OF POLITICAL ACTOR: NATURAL OR SELF-LEARNING ORGANIZATION
Authors:   Herzen University, Frolova Yu. N. , Nevzorov M. V. ,   Herzen University
Published: November 2023

The article addresses the issue of organizational culture of political actors within the principles of natural and self-learning organization. The relevance of the subject is determined by the formation of the system of public authority, as well as the need to create conceptual stability in relation to the organizational culture of the political actor. As a result, the orientations of actors (be it the state or actors inside/outside the state) on confirmantropic or negantropic biopolitics may be developed. Methodologically, the article is based on the theory of organizational metaphors by G.Morgan, the approaches of P.Senge, F.Selznick, and the concept of biopolitics by M.Foucault. Asserting the epistemological significance of the analytical separation of natural and self-learning organization in the analysis of actors, the authors assume that there is a duality and possible coexistence of these approaches in the study of the organizational culture of political actors. Such a phenomenon became possible due to the biopolitical revolution that leveled this gap. As a result, there is a paradoxical possibility of the formation of a negantropic biopolitics that denies the significant role of an autonomous individual and leadership, suggesting a rejection of the emergence of self-learning political actors.
VALUES AND SEMANTIC DOMINANTS OF POLITICAL MORALITY OF RUSSIAN YOUTH: A POLITICAL AND A PSYCHOLOGICAL ANALYSIS
Authors:   Lomonosov Moscow State University, Selezneva A. V. , Skipin N. S. ,   INION RAN,   Lomonosov Moscow State University, Turkov E. A. ,   Ludwig-Maximillian University of Munich
Published: November 2023

The study focuses on the lexico-semantic aspect of the political morality of modern Russian youth and is based on a set of methodological principles of political psychology and moral philosophy. The concepts presented in the article demonstrate that young people in Russia are forming a new political morality in terms of its semantic focuses. Based on traditional and new concepts with both immanent and introduced moral content, the political consciousness of Russian youth develops new ethical criteria for evaluating politics. These criteria are formulated as moral postulates of "give both to others and to oneself" with respect to politicians, and "I get everything and share with no one" with respect to oneself. The psychological significance of the criteria for the overall system of moral norms of youth is the elimination of a number of ethical constraints and the strengthening of egocentric, hedonistic and pragmatic attitudes in the minds of young people at the expense of subjective moral action. The analysis of the concepts revealed that the political morality of young Russians is characterized by an eclectic mix of content and meaning, fragmentation, cognitive simplicity, and emotional intensity, all of which limit its identification and motivational potential.
WORLD EXPERIENCE IN CO2 TRANSPORTATION
Authors: Vanchugov I.M. , Rezanov K.S. , Ulanov V.V. , Nazarova A. I. , Kayfadzhyan A.A. , Shestakov R.A.
Published: November 2023

In the modern world, greenhouse gases have a direct impact on global temperature rise throughout the Earth. There are various greenhouse gases, but one of the main ones is carbon dioxide — СО2, which is released not only during the combustion of organic fuel, but also during its extraction, as well as during various natural geological processes, such as volcanic eruptions.In the near future, according to the environmental decarbonization agenda, there will be a much more global deployment of projects for the capture and storage of carbon dioxide on an industrial base, especially in densely populated areas, so there will be a need to eliminate the main gaps in knowledge of the behavior of СО2 during transportation in the supercritical phase.The article provides an overview and analysis of carbon dioxide emissions on the territory of the Russian Federation — the regions with the highest СО2 emissions are identified and the need to study various options for transporting carbon dioxide in connection with large greenhouse gas emissions and the need to reduce them is shown.An analysis of a number of foreign carbon dioxide transport projects has been carried out, on the basis of which a benchmark with basic design data has been compiled. Special attention is paid to the transportation of carbon dioxide from the places of capture to the places of use or burial. Data on 37 pipeline СО2 transport systems located both on land and at sea are presented.The material also shows the main technical features of СО2 transportation related to the choice of pipeline material and energy machines for stream compression — the main problems in the field of СО2 transportation arising during the development of СО2 capture and storage projects are considered.Emergency situations that occurred on СО2 pipelines are considered separately, their consequences are reflected and the main causes of occurrence are identified, which include corrosion processes, as well as features of the physico-chemical properties of the transported product and its preparation for transportation through pipelines.
EFFICIENCY OF TREAD ALLOYS FOR VERTICAL STEEL TANKS
Authors: Katz N.G. , Ibatullin I.D. , Parfenova S.N.
Published: November 2023

The article discusses the use of various protector alloys made of magnesium and aluminum to protect vertical steel tanks when storing oil and oil products. Characteristics of protector alloys made of magnesium or aluminium and their alloys are shown. Data on the rate of selfdissolution of protector alloys depending on the degree of mineralization of bottom water are given. Gravimetric tests were used to calculate the mass index of the corrosion rate and electrochemical tests were used to calculate the efficiency of the anode current density. An empirical equation is shown by which the self-dissolution rate of protector alloys made of aluminum and magnesium alloys can be calculated, and empirical coefficients are given for the case of using protector alloys considered in the work. The obtained empirical dependence will make it possible to predict the rate of self-dissolution of aluminum and magnesium protector alloys. The efficiency of magnesium and aluminum protector alloys was analyzed and the dependence of the efficiency factor on the anode current density for magnesium and aluminum protector alloys was shown. Shows the effectiveness of using aluminum protector alloys to protect vertical steel tanks. It was concluded that the use of aluminum protector alloys is more efficient, since their efficiency is higher than that of magnesium alloys, this is clearly seen in the graph presented in the work on the dependence of the efficiency on the total mineralization of bottom water. The results of the work can be used in the design of protector protection for vertical steel tanks pre-designated for storage of oil and oil products containing produced water of various salinity.
MINIMIZING BHA FRACTURES AND INCREASING DRILLING SPEED IN OIL AND GAS WELLS
Authors: Zhivaeva V.V. , Lukyanov S.A.
Published: November 2023

The paper discusses horizontal completion drilling technology that uses telesystem diagnostic parameters to monitor the condition of the bottom hole BHA in order to increase wellbore penetration speed and reduce critical vibration and shock loads on BHA elements. The technology is based on solving the dependencies of penetration speed on the parameters of the rotary drilling mode and BHA vibrations using artificial neural networks and, in particular, the «random forest» method. During the development of the technology, a justification was given for the failure of the methods of classical mathematics due to the difficulty or impossibility of formalizing part of the influencing factors, as well as the discreteness of the values obtained from the face. An array of events of the drilled well was used for the study, the data of the GTE, the bottomhole telemetry complex and the on-board recorder of the drilling machine are tied to each other in depth and time. Events were sampled to obtain the correct data array for further investigation with similar parameters of drilling modes, the correct operation of the solved dependencies was tested for a part of the same array, and statistically significant results were obtained. A universal model has been built, with the help of which, based on previously received events, it is possible to obtain the necessary parameters of the rotary drilling mode to reduce the risks of BHA failure and increase the drilling speed. The model is selflearning and improves its quality by replenishing the base of reference events with new events. Thus, even if the wellbore trajectory or geological conditions change during drilling, the model remains applicable.
The Dynamics of the Housing Construction in the Republics of the USSR in the 1920s-1980s. Part 3
Authors: Pilipenko Igor
Published: November 2023

Despite 30 years of market reforms, the main difference between the housing sector in Russia and other post-socialist countries and that of the advanced Western nations lies in housing tenure distribution. In the former states, outright homeowners with property mainly built in the planned economy dominate the market. At the same time, in the latter countries, the majority of households pay rent or take out a mortgage (these types of households account for three-quarters of households in the USA and on average almost two-thirds of households in Western and Northern European nations). This article examines the evolution of main indicators of housing construction in the USSR as well as in the 15 Union republics from 1918 to 1990. The research rests upon a database composed by the author from more than 120 official statistical sources at the national and Republics' level. This work covers not only state housing construction but also individual housing construction as well as housing construction cooperatives in the USSR republics, which the post-Soviet and foreign scholarly literature have often neglected. We identify the main stages of housing construction in the USSR and analyze the data on housing completions in urban and rural areas, the evolution of the housing stock, flats and houses built, and the statistics on the people in the Union Republics who improved their living conditions. The time series collected and per capita indicators across the 15 republics of the USSR calculated by the author, reveal quite synchronized development of their housing sectors. Nevertheless, the three Baltic republics were leaders in many per capita indicators, whereas the RSFSR, the Kazakh, Byelorussian and Armenian SSR stood out in terms of housing completions and the share of people who improved their living conditions. At the same time, the Georgian, Ukrainian and Moldavian SSR excelled in floor area per person.
New Economic Policy in Documents of the Russian State Archive of the Economy
Authors: Myagkova Elena , Repnikov Aleksandr
Published: November 2023

A fundamental collection of documents has been prepared and published to mark the centenary of the beginning of new economic policy in Soviet Russia. The wide coverage shows processes taking place in the country during the mentioned period, which are reflected in the compromise nature of economic activities in such spheres as taxation of the village, grain procurement and agricultural co-operation, trust and syndication of nationalized industry, use of private capital for its restoration, private mediation between state bodies, development of stock-exchange and fair trade, the role of private trade in wholesale and retail trade, etc. The collection has been prepared on the basis of the documents and materials held in the Russian State Archive of the Economy. The materials for the collection were compiled by archivists who had studied and selected over 12,000 documents. The publication introduces little known and previously unpublished documents, showing the process of change in the economic life of the Soviet state in the difficult conditions of postwar devastation. It is the first time the whole picture of the Soviet economic life in agriculture, industry and trade is presented in a documentary form. The edition includes reference aids, including historical and archeographic preface, notes, name index and geographical index. It is intended for researchers, economists and all those interested in the political and economic history of Soviet Russia of the 1920s.
Aedes (Stegomyia) albopictus in rural areas in Brazil: First Record in the State of Ceara
Authors: Estelita Lima Cândido , Ulisses Mariano da Silva , Angélica Rodrigues de Souza Costa , Elayne Eally Silva de Oliveira Morais , Gledson Micael da Silva Leite , Carlos Wagner Oliveira
Published: November 2023

Background: This work aims to describe the finding of Aedes albopictus in an intra- and peridomiciliary area of the rural area in the south-central region of Ceará and discuss the need for entomological surveillance of this species in the country. Method: Through traps installed in an intra- and peridomiciliary environment and artificial breeding grounds, eggs and larvae of Ae. albopictus were captured in a rural area of the state of Ceará. Results: This is the first record of Ae. albopictus in the south-central region of the state of Ceará. We collected 418 eggs and 252 larvae from Ae. albopictus, being 85% of eggs in the peridomiciliary area, on average 29.41 (± 37.34) eggs per trap. As for larvae, about 70% of them were caught on tires. Only 42 larvae (14,2%) belonged to species other than the genus Aedes, found in tires and an engine. Conclusion: The presence of Ae. albopictus in rural areas close to urban areas warns of the need to effectively insert this vector as a surveillance target, carry out an active search, monitor its presence in municipalities, and investigate its involvement with outbreaks in or near areas where they are present.
Study on reliability of emergency braking performance of high-speed and heavy-load monorail crane
Authors: Zhang Jiarong , Lu Hao , Jiang Hui , Miao Yun , Shi Zhiyuan
Published: November 2023

The reliability of monorail crane braking system has an important influence on braking safety, high-speed and heavy-load operation, which poses great challenges to braking safety, and it is necessary to evaluate its braking reliability accurately and efficiently. Firstly, the dynamic performance and thermal-mechanical coupling characteristics of high-speed and heavy-load monorail crane under different braking parameters were analyzed. Secondly, the random response model of braking distance and braking temperature was established by combining the design of experiment method (DoE) and Dendrite Net (DD). Finally, the high-order moment saddlepoint approximation (SPA) method was used to evaluate the emergency braking reliability of the monorail crane. The results can provide a reference for the selection of key parameters and the evaluation of braking safety of the monorail crane braking system under high-speed and heavy-load conditions.
Navigating Workload Compatibility Between a Recommender System and a NoSQL Database: An Interactive Tutorial
Authors:   School of Information Systems and Management Muma College of Business University of South Florida, Kayhan Varol O. , Berndt Donald J. ,   School of Information Systems and Management Muma College of Business University of South Florida
Published: November 2023

In this tutorial, the issue of compatibility between a big data storage technology and an analytic workload is explored using a fictitious streaming company as an example. The tutorial offers an interactive approach to help students understand the importance of considering workload compatibility when adopting new technologies. We provide instructors with the following: two Jupyter Notebooks that analyze compatibility, a detailed instructor guide on how to execute these notebooks, lessons learned, and appendices containing solutions and explanations. This tutorial provides a valuable resource for instructors teaching courses in database systems, big data, and analytic concepts, helping students develop practical skills to navigate effectively the complexities of big data technologies.
Retrospective pharmacoeconomic study of antibiotic therapy in community-acquired pneumonia
Authors: Taube A. A. , Alexandrova T. V. , Demidova O. A. , Zhuravleva M. V.
Published: November 2023

Background. The global recommendations for the treatment strategy of community-acquired pneumonia (CAP) include the empirical prescription of antibiotic therapy (ABT) – beta-lactams, fluoroquinolones, macrolides until the results of laboratory tests are obtained to identify the etiological agent responsible for CAP to determine etiotropic therapy. According to the national Russian clinical guidelines, macrolides, fluoroquinolones, cephalosporins and aminopenicillins are recommended for empirical prescription. Meta-analyses found better outcomes in patients treated with a combination of macrolides with beta-lactam compared to beta-lactam alone. At the same time, the clinical benefit of adding macrolides to beta-lactams for the empirical treatment of moderate CAP remains controversial, since the difference in the results of therapy may depend on the age and comorbid conditions of patients.

Objective: to analyze the costs of treating CAP with various ABT strategies in order to optimize the cost structure of a medical organization and plan the budget of local healthcare systems.

Material and methods. A retrospective epidemiological analysis of extracts from 157 medical records of middle-aged patients in accordance with the World Health Organization classification treated in multidisciplinary medical organizations was carried out. The methods included frequency analysis, cost of illness analysis, cost minimization analysis, and cost-effectiveness analysis. Depth of research was 2 years.

Results. Frequency analysis revealed that the initial strategy of ceftriaxone and azithromycin combination (n=74; 47%) prevailed in prescriptions. In terms of the rate of prescriptions, ceftriaxone monotherapy (n=37; 24%) was in the second place. The analysis of the effectiveness of the selected ABT strategies showed that, in general, 113 (72%) of prescriptions were effective. Standard therapy strategies were equivalent in absolute costs and had a similar cost structure.

Conclusion. Doctors’ adherence to national clinical guidelines for CAP treatment was found when prescribing the initial empirical ABT, the dominant strategies were identified. Cost of illness analysis demonstrated that the applied strategies were optimal in terms of cost minimization, and cost-effectiveness ratio. The costs structure in therapy with various ABT strategies did not have significant differences. In medical organizations, they adhere to the most rational and cost-effective strategy for CAP treatment and prescribe ABT regimens in each individual case based on risk factors, as well as the results of studies of CAP pathogens sensitivity.
The prospects for the use of vitamin B12 derivatives in pharmacology
Authors: Torshin I. Yu. , Gromova O. A. , Maiorova L. A.
Published: November 2023

Background. The structure of corrin tetrapyrrole macrocycles (compounds similar in structure to vitamin B12) is a kind of universal chemical template for targeted drug delivery, and the development of chemical sensors and antidotes.

Objective: systematization of information on targeted modulation of certain corrins’ properties through chemical modifications.

Material and methods. Literature analysis using modern methods of topological and metric data analysis was carried out. All relevant publications (n=863) were extracted from the PubMed/MEDLINE database on request “(cobalamin OR Cobyrinic OR vitamin B12) AND (Molecular Conformation [MeSH Terms] OR Vitamin B 12/*analogs & derivatives/*chemistry [MeSH Terms] OR Vitamin B 12/*chemistry [MeSH Terms] OR Structure-Activity Relationship [MeSH Terms])”.

Results. Information was systematized on how it is possible to regulate the properties of vitamin B12 (cobalamin) derivatives by introducing specific substitutions of groups in the corrin ring, on chemical modifications of cobalamin derivatives, biosynthetic approaches to the synthesis of cobalamin derivatives, and the effects of interactions of these modified corrins with “small” inorganic and organic molecules.

Conclusion. The results obtained by systematic computer analysis of publications on corrins make it possible to reasonably form samples of candidate molecules for corrin studies in silico, in vitro, and in vivo.
Updated pharmacoeconomic analysis of atesolizumab efficiency compared with other PD-1 inhibitors in patients with advanced non-small cell lung cancer after chemotherapy
Authors: Zyryanov S. K. , Dyakov I. N.
Published: November 2023

Objective: to evaluate the pharmacoeconomic efficiency of atezolizumab (inhibitor of programmed death ligand 1 (PD-L1)) in comparison with other checkpoint inhibitors (inhibitors of programmed cell death protein 1 (PD-1)) in patients with advanced non-small cell lung cancer (NSCLC) after previous chemotherapy in the current conditions of the Russian healthcare system.

Material and methods. The study design was a retrospective analysis of publications and modeling. The previously performed pharmacoeconomic study was updated considering a decrease in the cost of pembrolizumab after the generic form was released on the market and actualization of calculated target population. Cost minimization analysis was carried out and the impact on the healthcare system budget was estimated when treating all NSCLC patients provided with PD-1/ PD-L1 inhibitors in the second and third lines of therapy with atezolizumab. For calculations, we used registered prices according to the state register of maximum selling prices and average weighted marginal wholesale markup according to the Federal Antimonopoly Service.

Results. In the cost minimization analysis, atezolizumab showed greater clinical and economic efficiency, its use reduces costs by 28.6% over 3 years compared to nivolumab and by 8.8% compared to pembrolizumab in the second and third lines of NSCLC therapy. The budget impact analysis demonstrated that if all patients in the target group currently receiving various PD-1/PD-L1 inhibitors in the second and third lines of NSCLC therapy were initially provided with atezolizumab, it would reduce the budget load over 3 years by 11.6%, or by 722.4 mln rubles.

Conclusion. The use of atezolizumab is pharmacoeconomically justified and feasible compared to nivolumab and pembrolizumab, even after a release of the generic version of the latter, and will reduce the costs of PD-1/PD-L1 inhibitors in the second and third lines of NSCLC therapy.
Effects of Temperature and Rainfall Pattern on The Abundance of Orthopteran Insects in Coal Mines Ecological Restoration Areas of Jharia Coal Fields, Jharkhand, India
Authors: Bidisha Ganguly  , L.B Singh
Published: November 2023

Ecological restoration on coal mines' overburden dumps provides a suitable environment for the study of primary succession. The Abundance and diversity study of orthopteran insects and their diversity pattern with temperature and rainfall provides a lot about the stage of succession and ecosystem complexity in the area. Orthopteran diversity of two sites covering ten years of plantation having different types of vegetation were monitored. Tropical conditions like changes in rainfall and temperature influence the abundance of insects. An increase in monsoon increases the abundance whereas as the temperature increases the abundance decreases. In herbaceous habitats, insects’ diversity increases which gives a recolonization pattern for the ecosystem. This helps to increase the livelihood and conservation of the ecosystem and directs to sustain the SDG 15 goal.
In Vitro Anti Inflammatory, Anti-Oxidant and Anti-Cancer Cell Line Studies on Mollugo Cerviana (L.) Ser
Authors: P. Padmapriya
Published: November 2023

Our traditional treatises on medicine have shown references to number of rare medicinal herbs prescribed to treat various ailments in human. An herbal plant preferred to treat fever, inflammation, rheumatic pain and wounds prevalently in the villages of the delta districts of Tamilnadu by name Mollugo cerviana was chosen for this research. The Ethanol extract of Mollugo cerviana was analysed for its in vitro anti-inflammatory, antioxidant and anticancer activity through standard procedures. The anti-inflammatory activity of the ethanol ethanolic extracts of varying concentrations were evaluated under HRBC (Human Red Blood Cell) Membrane Stabilization and Protein denaturation studies. Diclofenac sodium a nonsterioidal anti-inflammatory drug was the reference standard. The results revealed a concentration dependent increase in the percentage of membrane stabilization activity with increase in concentration of the test extract and a concentration dependent inhibition of protein (albumin) denaturation activity. Antioxidant studies revealed a significant free radical scavenging activity by the extract upon evaluation by DPPH free radical scavenging assay, nitric oxide assay and hydrogen peroxide radical scavenging activity assay. The studies on liver cancer cell lines using MTT assay revealed the anticancer activity exhibited by the ethanol extract of Mollugo cerviana. The studies as a whole reveals the anti-inflammatory, antioxidant and anticancer activity possessed by the herbal extract of Mollugo cerviana which invites attention to proceed with further research towards development of novel herbal drugs from Mollugo cerviana to treat inflammation and cancer.
Evaluation of the effectiveness of detoxification in the immunorehabilitation of cancer patients
Authors: Savchenko A. A. , Kasparov E. V. , Borisov S. A. , Masterova A. A. , Borisov Alexander G.
Published: November 2023

Purpose. Evaluation of the effectiveness of detoxification using enterosorbents in the immunorehabilitation of cancer patients.
Materials and methods. 87 patients with metastatic forms of solid tumors of various localizations with metastatic lesions were examined. The patients were divided into 2 groups: study group (41 patients who received detoxification therapy in addition to standard therapy) and comparison group (46 patients who received only standard therapy). The effectiveness of therapy with these drugs was evaluated after one month by assessing clinical and immunological parameters. The assessment of the state of cellular immunity was carried out by flow cytometry.
Results. Disturbances in the function of the immune system in the form of insufficiency of the cellular effector link of immunity were detected in all examined patients before the start of therapy. The state of the cellular link of immunity was characterized by an increase in the number of transitional and non-classical subsets of monocytes, an increase in the content of T-, B- and NKT-cells, but with a decrease in NK-cells. An increase in the ratio between the number of T-helpers (CD3+CD4+) and the number of cytotoxic T-cells (CD3+CD8+) was observed in the examined patients. Restoration of cell subsets to the level of control values was found in the examined patients after detoxification therapy as part of immunorehabilitation measures. Significant changes in the number of cells in the blood were absent in the comparison group after the therapy which indicated the absence of a complete relief of the systemic inflammatory response.
Conclusion. Chronic toxicosis with the development of a systemic inflammatory reaction on the background of the immune system dysfunctions were found in cancer patients. The use of enterosorbents in complex immunorehabilitation therapy is substantiated and confirmed by the relief of asthenovegetative and dyspeptic syndromes, normalization of the immune system which makes it possible to recommend detoxification therapy during immunorehabilitation measures.
Evaluation of physiological and immunological parameters in the offspring born from passively smoking rats treated with neuropeptides
Authors: Smolyagin Alexander I. , Simbirtsev Andrey S. , Mikhailova Irina V. , Ermolina Evgenia V. , Isengulova Ainagul A. , Pushkareva Ludmila A. , Kuzmicheva Natalia А. , Filippova Yulia V. , Chaynikova Irina N. , Miroshnichenko Igor V.
Published: November 2023

The results of physiological and immunological studies of rat pups born from females who were exposed to passive smoking and exposure to tetrapeptide KK1 during pregnancy are presented. From the 1st to the 21st postnatal days, the somatic and sensorimotor development of offspring was studied using a set of tests developed at the P.K. Anokhin Institute of Normal Physiology. The level of cytokines IFN gamma and IL-6 produced by rat splenocytes was studied in culture fluid by the ELISA method. In baby rats born from passively smoking females, compared with animals born from non-smoking rats, a decrease in the weight of baby rats was found, as well as a delay in the timeliness of somatic and sensorimotor development. The introduction of the peptide KK 1 non-smoking females increases the index of timeliness of somatic and sensorimotor development.

The results obtained show an induced variant of secondary immunodeficiency in baby rats born from passively smoking rats during pregnancy. Administration of the KK1 peptide to non-smoking rats did not change the immunological parameters of the baby rats. On the contrary, the production of peptide KK1 by pregnant rats who smoked was accompanied by changes in the number of cells in lymphoid organs and the production of cytokines by splenocytes in the born rats.
Cell-molecular immune mechanisms in the pathogenesis of polycystic ovarian syndrome
Authors: Valikova Olga V. , Zdor Victoria V.
Published: November 2023

The literature review is devoted to studies of the role of innate immunity cells mast cells in the pathogenesis of polycystic ovary syndrome. In recent years, the cells of innate immunity have been the subject of active research in the pathology of the endocrine system. Despite numerous studies of the mechanisms of the disease, the immunopathogenesis of polycystic ovary syndrome is still not clear, which does not allow to completely solve the complex of reproductive, metabolic and psychological problems in this pathology. The search for molecular markers to control the course and prognosis of the disease is an urgent medical problem.
Serum levels of cytokines in patients with retinal neurodegeneration in diabetic retinopathy on the background of type 2 diabetes mellitus
Authors: Markelova Elena V. , Ruchkin Mikhail P. , Fedyashev Gleb A.
Published: November 2023

The aim of the present study was to determine the serum level of IL-1, TNF- IL-17A, INF-, IL-10 in patients with retinal neurodegeneration against the background of type 2 diabetes mellitus. The study included 80 patients with type 2 diabetes mellitus, which were divided into 4 groups depending on the presence of vascular symptoms of diabetic retinopathy and retinal neurodegeneration. The level of cytokines was determined using solid-phase ELISA. In groups of patients with retinal neurodegeneration, a significant (p0.05) increase in IL-1 and a decrease in IL-10 were detected. The presence of vascular changes in the retina did not affect the level of cytokines studied. The identified changes show the role of systemic imbalance between pro- and anti-inflammatory cytokines in the induction of retinal neurodegeneration in diabetic retinopathy. Further study of this problem is required in order to search for possible immune markers of retinal neurodegeneration in patients with type 2 diabetes.
Ambiguity effects of recombinant interferon α2B in an in vitro experiment on the expression of nuclear factor NF-KB, IFNα’βR AND IFNγR (CD119) receptors of neutrophilic granulocytes of patients with chronic herpes virus infections
Authors: Nesterova Irina V. , Khalturina E. O. , Nelyubin V. N. , Khaidukov S. V. , Chudilova Galina A. , Malinovskaya V. V.
Published: November 2023

Introduction. Neutrophil granulocytes (NGs) and the interferons system (IFN) play a leading role in antiviral immune defense. At the same time, patients suffering from atypical chronic active herpes-viral infections (ACA-HVI) often have neutropenia and impaired induced IFN/ and IFN production. It is possible that these patients have various disorders of intracellular signaling at all stages of IFN/ synthesis by immune system cells, including NG, which leads to IFN/ deficiency. An adequate level of nuclear factor NF-kB expression has positive effects on synthesis of IFN/ in the last stages of signaling. The disturbances in the expression of NF-kB can lead to defects in the synthesis of IFN/.

The aim: to clarify the features of nuclear factor NF-kB, membrane receptors IFN|R and IFNR (CD119) expression on NG of patients with AСA-HVI, with the subsequent assessment of the recombinant IFN2b (recIFN2b) effects on them in the experimental system in vitro.

Materials and methods: 25 patients with ACA-HVI of both sexes aged 23-64 years were included in the main group of the study (MSG). In the complex of the study for the detection of herpes-viral infections: the method of serodiagnosis (ELISA), for the detection of the genome of viruses - PCR-RT. 407 blood samples were examined in the in vitro system. Flow cytofluorimetry was used to estimate the amount (%) of NG expressing NF-kB, IFN|R, IFNR, and their expression levels before and after incubation with recIFN2b. Adequate statistical methods were applied.

Results: In patients suffering from ACA-HVI, a deficiency of induced IFN and IFN production was detected, due to a decrease in the expression density of nuclear factor NF-kB NG, as well as a violation of the expression of membrane receptors IFN|R, IFNR. RecIFN2b in the in vitro system had a mixed effect on the expression of NF-kB, IFN|R and IFNR NG.

Conclusion: The deficiency of induced IFN and IFN production in patients with ACA-HVI is associated with variable changes in NF-kB, IFN|R and IFNR NG expression. RecIFN2b in the in vitro system has an ambiguous effect on altered expression of NF-kB, IFN/ and IFN NG, which appears to depend on the innate or adaptive nature of these disorders.
The effect of abdominal obesity on the level of inflammatory markers in young people with hypertension
Authors: Polonskaya Yana V. , Kashtanova Elena V. , Stakhneva Ekaterina M. , Shramko Victoria S. , Sadovski Evgeniy V. , Ledovskikh Sophia R. , Khudyakova Alena D. , Ragino Yulia I.
Published: November 2023

Objective: to investigate pro- and anti-inflammatory blood markers in young people with arterial hypertension (AH) against the background of abdominal obesity (AO).
Materials and methods: the study included 530 people, including 267 people with hypertension, of which 169 were with AO. In the control group (without AH) there were 263 people comparable in gender and age, with AO - 106 people. The content of TNF-α, IL-6, IL-8, MCP-1 (monocytic chemoatractant protein), PAI-1 (plasminogen activator inhibitor-1), IL-10, IL-17a, IL-17e, IL-17f were determined in all blood by multiplex analysis. Statistical processing was carried out in the SPSS 13.0 program.
Results: The level of IL-17a was 1.64 times higher in patients with hypertension (p0.05) compared to the control. The level of IL-6 in patients with hypertension was higher (p0.0001) by 52.91% compared to the group without hypertension. There was no difference between the control and the group with hypertension for the remaining biomarkers. The influence of AO on the level of the studied markers in the control group was not revealed. In the group with AH, a significantly higher level of PAI-1 (p0.05) was in the subgroup with AO. For subgroups with AO, the difference between patients without AH and with AH was manifested in a decrease in IL-17e and an increase in IL-6 in patients with AH (p0.05). No statistically significant difference was found for the remaining indicators. The relative chance of early hypertension was associated with the presence of AO and an increase in the level of IL-6.
Conclusion: From the markers of inflammation studied by us, an increased level of IL-6 and IL-17a can serve as potential biomarkers indicating a high probability of developing early hypertension in people under 45 years of age.
Contamination of soils by geohelminths ova in key social areas of Vladivostok
Authors: Tabakaeva Tatyana V. , Shchelkanov Michael Yu. , Galkina Irina V.
Published: November 2023

BACKGROUND: Geohellminthiasis constitutes approximately 90% of all parasitic diseases affecting the population. WHO recommends regular parasitological monitoring of the soil, for the subsequent assessment of its parasitic contamination and the development of epidemiological measures for the prevention of parasitoses among the population.
AIM: To study soil contamination by geohelminths ova in important social areas in the city of Vladivostok.
METHODS: Soil samples were collected from the territories of residential blocks, parks and playgrounds. In total, 671 soil samples were collected. Samples the collection was carried out according to MUC 4.2.796-99 and examined using the Romanenko method. The prevalence (%)and intensity of contamination per gram of soil sample were calculated.
RESULTS: In total, 7 morphological forms of geohelminth ova were found: Toxocara spp., Toxascaris leonina, Uncinaria stenocephala, Ascaris spp., Ancylostoma spp., Dypilidium caninum and Taenia spp. Propagative stages of helminths were found in 401 of 671 samples. The overall prevalence of contamination was 59.8%. Toxocara spp. were the most prevalent contaminating 300 (44.7%) of the samples. Geohelminths ova were found in soil samples at all sites. Parks and residential areas were the most contaminated.
CONCLUSION: Geohelminths ova were found in all kay social areas of Vladivostok warranting urgent epidemiological measures to improve the situation.
Impact of AI-based STOD(Stacking Owned Delivery) Efficiency on Rider Earnings: Focusing on Baedal Minjok Alddulbaedal
Authors:   The Korean Logistics Research Association, Lee Young-Chan , Lee Chul-Sung
Published: November 2023

The outsourcing of food delivery began in the late 1990s, and the growth of food delivery platforms provided consumers with the opportunity to access a variety of foods through delivery. However, due to the nature of the restaurant industry, food must be cooked upon ordering and delivered to the consumer in a warm state. This takes less than an hour, which makes it difficult for restaurants to expand their delivery service. Therefore, only 20.9% of total restaurant sales are generated through food delivery via phone orders and food delivery platforms, and sales through food delivery platforms are expected to be even lower. This outsourcing of food delivery is similar to changes in the logistics industry due to the development of e-commerce. The logistics industry has achieved economies of scale through a hub-and-spoke logistics system and made faster delivery to consumers a competitive advantage. Faster delivery has emerged as a major competitive factor in food delivery as well. However, unlike the general logistics industry, there is a problem in achieving economies of scale. To address these challenges, each food delivery platform invested in various technological developments. But with the high inflation rate continuing after COVID-19, consumer needs have changed. In response to these environmental changes, Baedal Minjok has launched an AI-based STOD(Stacking Owned Delivery) service that combines multiple orders into one delivery, thereby shifting away from the existing speed-centered competition. However, these changes raise questions about the effect that the launch of the AI-based STOD(Stacking Owned Delivery) service will have on earnings, as delivery riders perceive a high degree of uncertainty about their earnings. Therefore, in this study, we use the difference-in-difference method as a quasi-experimental design method, based on data from Woowa Youth, the operator of Baemin Connect, to examine the impact of AI-based STOD on efficiency and rider earnings. As a result, the monthly earnings of riders who used both AI-based STOD and single-house delivery increased by 5.1% compared to delivery riders who only used single-house delivery, and earnings per one delivery increased by 0.8%. Additionally, hourly earnings increased by 4.9%, demonstrating that the launch of STOD contributed to the increase in delivery rider earnings. Delivery rider earnings also increased similarly across regions. Based on these research results, we discuss the implications and limitations of this study.
Paraneoplastic cerebellar degeneration in a patient with metastatic endometrial cancer developed after two cycles of palliative chemotherapy: a clinical case
Authors: Shishkin A.  B. , Bogomolov V.  V. , Rikov I.  V. , Balluzek M.  F. , Shidakova D.  D.
Published: November 2023

A clinical case of an atypical course of paraneoplastic cerebellar degeneration that occurred during chemotherapy in a patient with an established diagnosis of metastatic endometrial cancer is presented.
Aplicación de la tradición oral como herramienta para el fortalecimiento de competencias del pensamiento histórico
Authors: Salamanca Leguizamón Carolina , Peñaranda Franco César Augusto , Amorocho Cala Dariany Mauricio , Barragán Chaparro Fernando
Published: November 2023

Durante mucho tiempo, se han utilizado métodos tradicionales como forma de aprendizaje para la historia en las ciencias sociales, existiendo más herramientas como la oratoria, por esa razón, el objetivo de esta investigación es aplicar la tradición oral como herramienta para el fortalecimiento de las competencias del pensamiento histórico en estudiantes del Instituto Técnico José Rueda del Palmar. Además, se parte de un análisis dirigido hacia los estudiantes, quienes ven el área de historia por medio de métodos tradicionales. A partir de ello se diseñaron y aplicaron cuestionarios que permitieron destacar a los alumnos de noveno grado como la muestra de investigación, luego de reconocer falencias que tenıá n. Por ello, se realiza este proyecto, buscando de esta forma que los estudiantes comprendan e interpreten el conocimiento que adquieran sobre historia nacional por medio de la tradición oral como herramienta de enseñanza. Para cumplir los objetivos se utilizó un método cualitativo descriptivo compuesto primeramente por la aplicación de un cuestionario diagnóstico para la identificación de falencias en el pensamiento histórico, y finalmente un cuestionario para demostrar el fortalecimiento de las competencias en la historia, luego de la aplicación de la tradición oral como herramienta de aprendizaje. Culminado el trabajo de campo se logró concluir que efectivamente la herramienta de aprendizaje fortaleció las competencias del pensamiento histórico en los estudiantes.