bluuebunny/crossref_metadata_2025 huggingface dataset:
A New Detection Method of Oral and Oropharyngeal Squamous Cell Carcinoma Based on Multivariate Analysis of Surface Enhanced Raman Spectra of Salivary Exosomes
Authors: Faur Cosmin Ioan , Dinu Cristian , Toma Valentin , Jurj Anca , Mărginean Radu , Onaciu Anca , Roman Rareș Călin , Culic Carina , Chirilă Magdalena , Rotar Horațiu , Fălămaș Alexandra , Știufiuc Gabriela Fabiola , Hedeșiu Mihaela , Almășan Oana , Știufiuc Rares Ionuț
Published: May 2023

Raman spectroscopy recently proved a tremendous capacity to identify disease-specific markers in various (bio)samples being a non-invasive, rapid, and reliable method for cancer detection. In this study, we first aimed to record vibrational spectra of salivary exosomes isolated from oral and oropharyngeal squamous cell carcinoma patients and healthy controls using surface enhancement Raman spectroscopy (SERS). Then, we assessed this method’s capacity to discriminate between malignant and non-malignant samples by means of principal component–linear discriminant analysis (PC-LDA) and we used area under the receiver operating characteristics with illustration as the area under the curve to measure the power of salivary exosomes SERS spectra analysis to identify cancer presence. The vibrational spectra were collected on a solid plasmonic substrate developed in our group, synthesized using tangential flow filtered and concentrated silver nanoparticles, capable of generating very reproducible spectra for a whole range of bioanalytes. SERS examination identified interesting variations in the vibrational bands assigned to thiocyanate, proteins, and nucleic acids between the saliva of cancer and control groups. Chemometric analysis indicated discrimination sensitivity between the two groups up to 79.3%. The sensitivity is influenced by the spectral interval used for the multivariate analysis, being lower (75.9%) when the full-range spectra were used.
The Utility of Ultrasound in Evaluating Joint Pain in Systemic Lupus Erythematosus: Looking beyond Fibromyalgia
Authors: Song Yeohan , Kirsch Gabriel , Jarjour Wael
Published: May 2023

Background: Systemic lupus erythematosus (SLE) is a complex autoimmune condition with varied clinical presentations, and musculoskeletal pain is one of the most commonly associated symptoms. However, fibromyalgia (FM) is a prevalent co-existing condition in SLE patients that can also cause widespread pain, and in patients with both conditions, it is often difficult to distinguish the underlying cause of musculoskeletal pain and provide optimal therapy. Methods: A retrospective cohort study was conducted including all adult SLE patients who received musculoskeletal ultrasound (US) examinations for joint pain at the Ohio State University Wexner Medical Center between 1 July 2012, and 30 June 2022. Binary and multiple logistic regression analyses were performed to determine predictors of US-detected inflammatory arthritis as well as improved musculoskeletal pain. Results: A total of 31 of 72 SLE patients (43.1%) had a co-existing diagnosis of FM. In binary logistic regression, a co-existing diagnosis of FM was not significantly associated with US-detected inflammatory arthritis. In multiple logistic regression analysis, clinically detected synovitis was significantly associated with US-detected inflammatory arthritis (aOR, 142.35, p < 0.01), and there was also a weak association with erythrocyte sedimentation rate (ESR) (aOR 1.04, p = 0.05). In separate multiple logistic regression analysis, US-guided intra-articular steroid injection was the only predictor of improved joint pain at follow-up visit (aOR 18.43, p < 0.001). Conclusions: Musculoskeletal US can be an effective modality to detect inflammatory arthritis as well as to guide targeted intra-articular steroid injection to alleviate joint pain in SLE patients with or without FM.
The Real Post-Operative Range of Motion Differs from the Virtual Pre-Operative Planned Range of Motion in Reverse Shoulder Arthroplasty
Authors: Berhouet Julien , Samargandi Ramy , Favard Luc , Turbillon Céline , Jacquot Adrien , Gauci Marc-Olivier
Published: May 2023

Introduction: The purpose of this study was to analyze the real range of motion (RoM) measured in patients operated on for reverse shoulder arthroplasty (RSA) and compare it to the virtual RoM provided by the preoperative planning software. Hypothesis: There was a difference between virtual and real RoM, which can be explained by different factors, specifically the scapula-thoracic (ST) joint. Methods: Twenty patients with RSA were assessed at a minimum follow-up of 18 months. Passive RoM in forward elevation abduction, without and with manually locking the ST joint, and in external rotation with arm at side were recorded. The humerus, scapula, and implants were manually segmented on post-operative CTs. Post-operative bony structures were registered to preoperative bony elements. From this registration, a post-operative plan corresponding to the real post-operative implant positioning was generated and the corresponding virtual RoM analysis was recorded. On the post-operative anteroposterior X-rays and 2D-CT coronal planning view, the glenoid horizontal line angle (GH), the metaphyseal horizontal line angle (MH), and the gleno-metaphyseal angle (GMA) were measured to assess the extrinsic glenoid inclination, as well as the relative position of the humeral and glenoid components. Results: There were some significant differences between virtual and post-operative passive abduction and forward elevation, with (55° and 50°, p < 0.0001) or without ST joint participation (15° and 27°, p < 0.002). For external rotation with arm at side, there was no significant difference between planning (24° ± 26°) and post-operative clinical observation (19° ± 12°) (p = 0.38). For the angle measurements, the GMA was significantly higher (42.8° ± 15.2° vs. 29.1°± 18.2°, p < 0.0001), and the GH angle, significantly lower on the virtual planning (85.2° ± 8.8° vs. 99.5° ± 12.5°, p < 0.0001), while the MH was not different (p = 0.33). Conclusions: The virtual RoM given by the planning software used in this study differs from the real post-operative passive RoM, except for external rotation. This can be explained by the lack of ST joint and soft tissues simulation. However, in focusing on the virtual GH participation, the simulation looks informative. Some modifications between the glenoid and humerus starting positions before running the motion analysis could be provided for making it more realistic and predictive of the RSA functional results. Level of evidence: III.
Avatar Intervention for Cannabis Use Disorder in Individuals with Severe Mental Disorders: A Pilot Study
Authors: Giguère Sabrina , Potvin Stéphane , Beaudoin Mélissa , Dellazizzo Laura , Giguère Charles-Édouard , Furtos Alexandra , Gilbert Karine , Phraxayavong Kingsada , Dumais Alexandre
Published: May 2023

Cannabis use disorder (CUD) is a complex issue, even more so when it is comorbid with a severe mental disorder (SMD). Available interventions are at best slightly effective, and their effects are not maintained over time. Therefore, the integration of virtual reality (VR) may increase efficacy; however, it has not yet been investigated in the treatment of CUD. A novel approach, avatar intervention for CUD, uses existing therapeutic techniques from other recommended therapies (e.g., cognitive behavioral methods, motivational interviewing) and allows participants to practice them in real-time. During immersive sessions, participants are invited to interact with an avatar representing a significant person related to their drug use. This pilot clinical trial aimed to evaluate the short-term efficacity of avatar intervention for CUD on 19 participants with a dual diagnosis of SMD and CUD. Results showed a significant moderate reduction in the quantity of cannabis use (Cohen’s d = 0.611, p = 0.004), which was confirmed via urinary quantification of cannabis use. Overall, this unique intervention shows promising results. Longer-term results, as well as comparison with classical interventions in a larger sample, are warranted through a future single-blind randomized controlled trial.
Upregulated Expression of ErbB1 in Diffuse Large B-Cell Lymphoma as a Predictor of Poor Overall Survival Outcome
Authors: Qazi Sanjive , Uckun Fatih M.
Published: May 2023

We examined the transcript-level expression of ErbB family protein tyrosine kinases, including ERBB1, in primary malignant lymphoma cells from 498 adult patients with diffuse large B-cell lymphoma (DLBCL). ERBB1 expression in DLBCL cells was significantly higher than in normal B-lineage lymphoid cells. An upregulated expression of ERBB1 mRNA in DLBCL cells was correlated with an amplified expression of mRNAs for transcription factors that recognized ERBB1 gene promoter sites. Notably, amplified ERBB1 expression in DLBCL and its subtypes were associated with significantly worse overall survival (OS). Our results encourage the further evaluation of the prognostic significance of high-level ERBB1 mRNA expression and the clinical potential of ERBB1-targeting therapeutics as personalized medicines in high-risk DLBCL.
Preoperative Planning for Reverse Shoulder Arthroplasty: Does the Clinical Range of Motion Match the Planned 3D Humeral Displacement?
Authors: Yoon Diane Ji Yun , Odri Guillaume-Anthony , Favard Luc , Samargandi Ramy , Berhouet Julien
Published: May 2023

Introduction: The functional outcome after reverse shoulder arthroplasty (RSA) is closely linked to how much the humerus shifts because of the implants. While two-dimensional (2D) angle measurements have been used to capture this shift, it can be measured in three dimensions (3D) as the arm change position (ACP). In a previous study, the ACP was measured using 3D preoperative planning software with the passive virtual shoulder range of motion obtained after RSA. The main objective of this study was to evaluate the relationship between the ACP and the actual active shoulder range of motion measured after RSA. The hypothesis was that the ACP and the active clinical range of motion are related such that the ACP is a reliable parameter to guide the preoperative planning of an RSA. The secondary objective was to assess the relationship between 2D and 3D humeral displacement measurements. Materials and methods: This prospective observational study enrolled 12 patients who underwent RSA and had a minimum follow-up of 2 years. The active range of motion in shoulder flexion, abduction, and internal and external rotation was measured. At the same time, ACP measurements were taken from a reconstructed postoperative CT scan, in addition to the radiographic measurements of humeral lateralization and distalization angles on AP views in neutral rotation. Results: The mean humeral distalization induced by RSA was 33.3 mm (±3.8 mm). A non-statistically significant increase in shoulder flexion was observed for humeral distalization beyond 38 mm (R2 = 0.29, p = 0.07). This “threshold” effect of humeral distalization was also observed for the gains in abduction, as well as internal and external rotations, which seemed better with less than 38 mm or even 35 mm distalization. No statistical correlation was found between the 3D ACP measurements and 2D angle measurements. Conclusion: Excessive humeral distalization seems to be detrimental to joint mobility, especially shoulder flexion. Humeral lateralization and humeral anteriorization measured using the ACP seem to promote better shoulder range of motion, with no threshold effect. These findings could be evidence of tension in the soft tissues around the shoulder joint, which should be taken into consideration during preoperative planning.
Recent Developments in Pharmacotherapy of Depression: Bench to Bedside
Authors: Shad Mujeeb U.
Published: May 2023

For the last 70 years, we did not move beyond the monoamine hypothesis of depression until the approval of the S-enantiomer of ketamine, an N-methyl-D-aspartate (NMDA) receptor blocker and the first non-monoaminergic antidepressant characterized by rapid antidepressant and antisuicidal effects. A similar profile has been reported with another NMDA receptor antagonist, dextromethorphan, which has also been approved to manage depression in combination with bupropion. More recently, the approval of a positive allosteric modulator of GABA-A receptors, brexanolone, has added to the list of recent breakthroughs with the relatively rapid onset of antidepressant efficacy. However, multiple factors have compromised the clinical utility of these exciting discoveries in the general population, including high drug acquisition costs, mandatory monitoring requirements, parenteral drug administration, lack of insurance coverage, indirect COVID-19 effects on healthcare systems, and training gaps in psychopharmacology. This narrative review aims to analyze the clinical pharmacology of recently approved antidepressants and discuss potential barriers to the bench-to-bedside transfer of knowledge and clinical application of exciting recent discoveries. Overall, clinically meaningful advances in the treatment of depression have not reached a large proportion of depressed patients, including those with treatment-resistant depression, who might benefit the most from the novel antidepressants.
Influence of Mechanical Alignment on Functional Knee Phenotypes and Clinical Outcomes in Primary TKA: A 1-Year Prospective Analysis
Authors: Rak Dominik , Klann Lukas , Heinz Tizian , Anderson Philip , Stratos Ioannis , Nedopil Alexander J. , Rudert Maximilian
Published: May 2023

In total knee arthroplasty (TKA), functional knee phenotypes are of interest regarding surgical alignment strategies. Functional knee phenotypes were introduced in 2019 and consist of limb, femoral, and tibial phenotypes. The hypothesis of this study was that mechanically aligned (MA) TKA changes preoperative functional phenotypes, which decreases the 1-year Forgotten Joint (FJS) and Oxford Knee Score (OKS) and increases the 1-year WOMAC. All patients included in this study had end-stage osteoarthritis and were treated with a primary MA TKA, which was supervised by four academic knee arthroplasty specialists. To determine the limb, femoral, and tibial phenotype, a long-leg radiograph (LLR) was imaged preoperatively and two to three days after TKA. FJS, OKS, and WOMAC were obtained 1 year after TKA. Patients were categorized using the change in functional limb, femoral, and tibial phenotype measured on LLR, and the scores were compared between the different categories. A complete dataset of preoperative and postoperative scores and radiographic images could be obtained for 59 patients. 42% of these patients had a change of limb phenotype, 41% a change of femoral phenotype, and 24% a change of tibial phenotype of more than ±1 relative to the preoperative phenotype. Patients with more than ±1 change of limb phenotype had significantly lower median FJS (27 points) and OKS (31 points) and higher WOMAC scores (30 points) relative to the 59-, 41-, and 4-point scores of those with a 0 ± 1 change (p < 0.0001 to 0.0048). Patients with a more than ±1 change of femoral phenotype had significantly lower median FJS (28 points) and OKS (32 points) and higher WOMAC scores (24 points) relative to the 69-, 40-, and 8-point scores of those with a 0 ± 1 change (p < 0.0001). A change in tibial phenotype had no effect on the FJS, OKS, and WOMAC scores. Surgeons performing MA TKA could consider limiting coronal alignment corrections of the limb and femoral joint line to within one phenotype to reduce the risk of low patient-reported satisfaction and function at 1-year.
Atrial Fibrillation Related Coronary Embolism: Diagnosis in the Focus
Authors: Balogh László , Óvári Péter , Ugbodaga Christopher Uwaafo , Csanádi Zoltán
Published: May 2023

Atrial fibrillation (AF) is the most common arrhythmia in myocardial infarction (MI). AF can be caused by ischemia, and MI can be caused by AF. Additionally, 4–5% of MI cases are related to coronary embolism (CE), and one-third of cases are attributed to AF. Our aim was to investigate the prevalence of AF-related CE cases among 3 consecutive years of STEMI cases. We also aimed to reveal the diagnostic accuracy of the Shibata criteria scoring system and the role of thrombus aspiration. Among 1181 STEMI patients, 157 had AF (13.2%). By using the Shibata’s diagnostic criteria, 10 cases were classified as ‘definitive’ and 31 as ‘probable’ CE. After re-evaluation, a further five cases were classified as ‘definitive’. Further analysis of the 15 CE cases revealed that CE was more prevalent in patients with previously known (n = 10) compared to those with new-onset (n = 5) AF (16.7% vs. 5.1%, p = 0.024). A PubMed search was performed, and 40 AF-related cases were found where the Shibata’s criteria could be applied. Further, 31 cases could be classified as ‘definitive’, 4 as ‘probable’ and, in 5 cases, the embolic origin could be excluded. In 40% of reported cases and in 47% of our cases, thrombus aspiration helped in diagnosis.
Singlet Oxygen In Vivo: It Is All about Intensity—Part 2
Authors: Hackbarth Steffen , Gao Shanghui , Šubr Vladimír , Lin Lisheng , Pohl Jakob , Etrych Tomáš , Fang Jun
Published: May 2023

Recently, we reported induced anoxia as a limiting factor for photodynamic tumor therapy (PDT). This effect occurs in vivo if the amount of generated singlet oxygen that undergoes chemical reactions with cellular components exceeds the local oxygen supply. The amount of generated singlet oxygen depends mainly on photosensitizer (PS) accumulation, efficiency, and illumination intensity. With illumination intensities above a certain threshold, singlet oxygen is limited to the blood vessel and the nearest vicinity; lower intensities allow singlet oxygen generation also in tissue which is a few cell layers away from the vessels. While all experiments so far were limited to light intensities above this threshold, we report experimental results for intensities at both sides of the threshold for the first time, giving proof for the described model. Using time-resolved optical detection in NIR, we demonstrate characteristic, illumination intensity-dependent changes in signal kinetics of singlet oxygen and photosensitizer phosphorescence in vivo. The described analysis allows for better optimization and coordination of PDT drugs and treatment, as well as new diagnostic methods based on gated PS phosphorescence, for which we report a first in vivo feasibility test.
A Comparative Study to Investigate the Effects of Bisoprolol in Patients with Chronic Heart Failure and Hypertension When Switched from Tablets to Transdermal Patches
Authors: Sezai Akira , Sekino Hisakuni , Taoka Makoto , Osaka Shunji , Tanaka Masashi
Published: May 2023

Background: Oral beta-blockers are effective for heart failure and hypertension. Here, we conducted a prospective study to investigate the efficacy of the beta-blocker bisoprolol in patients switching from the oral tablet to the transdermal patch. Methods: We studied 50 outpatients receiving oral bisoprolol for chronic heart failure and hypertension. After patients switched treatments, we measured heart rate (HR) over 24 h by Holter echocardiography as the primary endpoint. Secondary endpoints were (1) HR at 00:00, 06:00, 12:00, and 18:00, (2) the total number of premature atrial contractions (PACs) over 24 h and the incidence rate per time segment, and the total number of premature ventricular contractions (PVCs) over 24 h and the incidence rate per time segment, (3) blood pressure, (4) atrial natriuretic peptide and B-type natriuretic peptide, and (5) echocardiography. Results: Minimum, maximum, mean, and total HR over 24 h was not significantly different between the two groups. Mean and maximum HR at 06:00, total PACs, total PVCs, and PVCs at 00:00 to 05:59 and 06:00 to 11:59 were significantly lower in the patch group. Conclusion: Compared with oral bisoprolol, the bisoprolol transdermal patch lowers HR at 06:00 and inhibits the onset of PVCs during sleep and in the morning.
Comparison of the Incidence of Postoperative Acute Kidney Injury Following the Administration of Remimazolam or Sevoflurane in Elderly Patients Undergoing Total Knee Arthroplasty: A Randomized Controlled Trial
Authors: Lee Sangho , Kang Hee Yong , Ahn Ye Na , You Ann Hee
Published: May 2023

Background: We evaluated the incidence of postoperative acute kidney injury (AKI) and complications when remimazolam (RMMZ) or sevoflurane (SEVO) were used in elderly patients undergoing total knee arthroplasty. Methods: Seventy-eight participants aged ≥65 were randomly allocated to either the RMMZ or SEVO group. The primary outcome was the incidence of AKI on postoperative day (POD) 2. The secondary outcomes included intraoperative heart rate (HR), blood pressure (BP), total drug administered, emergence time, postoperative complications on POD 2, and hospital length of stay (HLOS). Results: The incidence of AKI was comparable between the RMMZ and SEVO groups. The doses of intraoperative remifentanil, vasodilators, and additional sedatives were significantly higher in the RMMZ group than in the SEVO group. Overall intraoperative HR and BP tended to remain higher in the RMMZ group. The emergence time in the operating room was significantly faster in the RMMZ group; however, the time required for an Aldrete score ≥ 9 was comparable between the RMMZ and SEVO groups. Postoperative complications and HLOS were comparable between the RMMZ and SEVO groups. Conclusion: RMMZ may be recommended for patients who are expected to decrease in intraoperative vital signs. However, stable hemodynamics with RMMZ were not sufficient to influence the prevention of AKI.
Effects of Bacillus subtilis Natto NB205 and Its Mutant NBMK308 on Egg Quality in Aging Laying Hens
Authors: Liao Chaoyong , Cui Jian , Lei Jiaqi , Guo Yuming , Zhang Bingkun
Published: May 2023

In aging laying hens, reproductive changes reduce egg quality. Bacillus subtilis natto (B. subtilis) is a versatile bacterium with high vitamin K2 content, providing health benefits for animals and humans. This study investigated the effect of B. subtilis natto NB205 and its mutant NBMK308 on egg quality in aging laying hens. Results showed that NB205 and NBMK308 supplementation significantly improved albumen height (p < 0.001), Haugh units (p < 0.05), and eggshell thickness (p < 0.001) compared to the control group. Supplementation also increased ovalbumin expression, regulated tight junction (TJ) proteins, reduced pro-inflammatory cytokine levels, and improved the health and productivity of aging laying hens by regulating key apoptosis-related genes in the magnum part of the oviduct. There were differences in the expression of vitamin K-dependent proteins (VKDPs) in the magnum between NB205 and NBMK308, but no significant differences in the improvement of egg quality. Supplementation with NB205 and NBMK308 can improve egg quality in aging laying hens.
Up- and Downregulated Genes after Long-Term Muscle Atrophy Induced by Denervation in Mice Detected Using RNA-Seq
Authors: Sawano Shoko , Fukushima Misaki , Akasaka Taiki , Nakamura Mako , Tatsumi Ryuichi , Ikeuchi Yoshihide , Mizunoya Wataru
Published: May 2023

Skeletal muscle atrophy occurs rapidly as a result of inactivity. Although there are many reports on changes in gene expression during the early phase of muscle atrophy, the patterns of up-and downregulated gene expression after long-term and equilibrated muscle atrophy are poorly understood. In this study, we comprehensively examined the changes in gene expression in long-term denervated mouse muscles using RNA-Seq. The murine right sciatic nerve was denervated, and the mice were housed for five weeks. The cross-sectional areas of the hind limb muscles were measured using an X-ray CT system 35 days after denervation. After 28 d of denervation, the cross-sectional area of the muscle decreased to approximately 65% of that of the intact left muscle and reached a plateau. Gene expression in the soleus and extensor digitorum longus (EDL) muscles on the 36th day was analyzed using RNA-Seq and validated using RT-qPCR. RNA-Seq analysis revealed that three genes—Adora1, E230016M11Rik, and Gm10718—were upregulated and one gene—Gm20515—was downregulated in the soleus muscle; additionally, four genes—Adora1, E230016M11Rik, Pigh, and Gm15557—were upregulated and one gene—Fzd7—was downregulated in the EDL muscle (FDR < 0.05). Among these genes, E230016M11Rik, one of the long non-coding RNAs, was significantly upregulated in both the muscles. These findings indicate that E230016M11Rik could be a candidate gene for the maintenance of atrophied skeletal muscle size and an atrophic state.
Preamble to the Special Edition Plants and Microgravity
Authors: Kordyum Elizabeth , Hasenstein Karl H.
Published: May 2023

The need to study plant systems in space has a long history and space experiments on plants were recognized for their scientific value and as necessity to provide life support for humans and other non-photosynthetic organisms [...]
Circadian Genes MBOAT2/CDA/LPCAT2/B4GALT5 in the Metabolic Pathway Serve as New Biomarkers of PACA Prognosis and Immune Infiltration
Authors: Wang Qingqing , Zhou Shuning , Hu Xinyi , Wang Xianggang , Wu Xue , Huai Ziyou , Gao Yu , Li Shujing
Published: May 2023

Pancreatic cancer (PACA) is a highly malignant tumor with a poor prognosis. Recent studies have discovered substantial differences in the expression levels of several circadian genes in PACA samples compared to normal samples. The goal of this research was to find differentially expressed rhythm genes (DERGs) in PACA samples and determine their role in the development of PACA. A total of 299 DERGs were identified in PACA, including 134 downregulated genes and 165 upregulated genes. DERGs were significantly abundant in the metabolic pathway and immune response pathways, according to GO and KEGG analyses. Survival analyses showed that PACA patients who had higher expression levels of MBOAT2/CDA/LPCAT2/B4GALT5 had shorter overall survival times. Using cell assay verification, the mRNA levels of MBOAT2/CDA/LPCAT2/B4GALT5 in Patu-8988 and PNAC-1 cells were found to be significantly higher than those in HPDE6-C7 cells, which was in line with previous studies on PACA patient data. Through conducting univariate Cox analysis, it was determined that MBOAT2/CDA/LPCAT2/B4GALT5 expression, age and grade were all high-risk factors. The MBOAT2/CDA/LPCAT2/B4GALT5 genes were independently correlated with overall survival, according to the multivariate Cox analysis. The proportion of immune cells in PACA and normal samples significantly changed, according to the immune infiltration analysis. Furthermore, MBOAT2/CDA/LPCAT2/B4GALT5 expression levels were significantly related to the level of immune cell infiltration. The protein–protein interaction network of the MBOAT2/CDA/LPCAT2/B4GALT5 genes included 54 biological nodes and 368 interacting genes. In conclusion, the finding of these DERGs adds to the investigation of the molecular processes underlying the onset and progression of PACA. In the future, DERGs may serve as prognostic and diagnostic biomarkers as well as drug targets for chronotherapy in PACA patients.
Cook with Different Pots, but Similar Taste? Comparison of Phase Angle Using Bioelectrical Impedance Analysis According to Device Type and Examination Posture
Authors: Yang Jihyun , Kim Jeehyun , Chun Byung-chul , Lee Jae-myeong
Published: May 2023

Bioelectrical impedance analysis (BIA) is gaining popularity as a tool for body composition assessment. Although BIA has been studied and validated in different populations, age groups, and clinical settings, including critically ill patients, there are concerns about BIA reproducibility and reliability for different device types and postures. This study aimed to evaluate the reliability of BIA using different devices, postures, and lead types. Cross-sectional observational data were collected from 74 healthy volunteers (32 women, 42 men). We used two types of devices, three types of postures (standing, sitting, and lying), and two lead types (clamp lead and adhesive lead) to measure the whole-body phase angle (phA) at a single frequency of 50 kHz. The measurements were validated using the intraclass correlation coefficient (ICC) and Bland–Altman plot analysis. All phA measurements recorded using the two types of devices, three different postures, and two types of leads were equivalent (mean ICC = 0.9932, 95% confidence interval (CI) 0.9905–0.0053, p < 0.001). The average mean difference in phA was 0.31 (95% CI 0.16–0.46). The largest phA value was measured using BWA with an adhesive-type lead in the supine position. There were no differences between the standing and sitting positions. We compared the consistency and reliability of phA using two devices, two lead types, and three postures. Seven different phA were interchangeable in healthy volunteers.
Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies
Authors: Musa Mutali , Zeppieri Marco , Atuanya George Nnamdi , Enaholo Ehimare S. , Topah Efioshiomoshi Kings , Ojo Oluwasola Michael , Salati Carlo
Published: May 2023

Glaucoma is a chronic optic neuropathy that can lead to irreversible functional and morphological damage if left untreated. The gold standard therapeutic approaches in managing patients with glaucoma and limiting progression include local drops, laser, and/or surgery, which are all geared at reducing intraocular pressure (IOP). Nutrients, antioxidants, vitamins, organic compounds, and micronutrients have been gaining increasing interest in the past decade as integrative IOP-independent strategies to delay or halt glaucomatous retinal ganglion cell degeneration. In our minireview, we examine the various nutrients and compounds proposed in the current literature for the management of ophthalmology diseases, especially for glaucoma. With respect to each substance considered, this minireview reports the molecular and biological characteristics, neuroprotective activities, antioxidant properties, beneficial mechanisms, and clinical studies published in the past decade in the field of general medicine. This study highlights the potential benefits of these substances in glaucoma and other ophthalmologic pathologies. Nutritional supplementation can thus be useful as integrative IOP-independent strategies in the management of glaucoma and in other ophthalmologic pathologies. Large multicenter clinical trials based on functional and morphologic data collected over long follow-up periods in patients with IOP-independent treatments can pave the way for alternative and/or coadjutant therapeutic options in the management of glaucoma and other ocular pathologies.
Influence of the Distribution of Pits on the Friction and Wear Performance of Textured Rolling Bearings under Starved Lubrication
Authors: Chen Yazhe , Long Risheng , Jin Zhihao , Zhao Chen , Wang Ming
Published: May 2023

Most of the published documents on the friction and wear properties of textured contact surfaces with partially distributed units (e.g., dots, grooves) are focused on sliding tribo-pairs or journal bearings. To study the friction and wear performance of rolling bearings with different distributions of pits, several patterns were introduced: OS-1/4 (Outside, 1/4 of raceway), OS-1/2 (Outside, 1/2 of raceway), OS-3/4 (Outside, 3/4 of raceway), IS-1/4 (Inside, 1/4 of raceway), IS-1/2 (Inside, 1/2 of raceway), IS-3/4 (Inside, 3/4 of raceway), TS (Two sides, 2/3 of raceway), FT (fully textured) and SR (Smooth reference), with two circumferential interval angles (CFIAs, 1.5° and 2.0°). The dimensions of the pits are the same in all patterns (diameter of 300 μm and depth of 15 μm), which were only prepared on the raceways of the shaft washers of 81107 bearings (nylon cages) using the laser marking method. All bearings were tested under 4000 N, 250 RPM and starved lubrication using a vertical universal wear test rig. Their mass losses and worn raceways were measured and observed. Their surface equivalent stresses were also analyzed and compared. The obtained results show that the influence of different distributions of pits on the tribological properties of rolling bearings is significant. The friction-reducing and anti-wear performance of TS is acceptable, whether the CFIA is 1.5° or 2.0°. A fully textured pattern cannot provide the best tribological properties and its behavior even becomes worse when the CFIA is 2.0°. In this work, when the CFIA is 1.5°, the friction-reducing and anti-wear performance of OS-1/4 is the best among all patterns. Using a smooth reference as a benchmark for comparison, its friction-reducing and anti-wear performance can be enhanced by 60.46% and 16.05%, respectively. The results of this work will be an important reference for the optimal design of the “washers-cage-rollers” contact system for rolling bearings.
Frictional Response of Reinforced Polymers under Quasistatic and Fast-Transient Dry Contact Conditions
Authors: Tonazzi Davide , Betsch Etienne , Pages Alexandre , Massi Francesco
Published: May 2023

Reinforced polymers have recently gained interest because of their high stiffness associated with the classical features and cost-effectiveness of polymers. A further characteristic, suitable for several applications, is the possibility to provide high frictional and wear resistance. The frictional response of commercially available reinforced materials was here investigated in a wide range of contact boundary conditions. Experimental tests were performed on different test benches, to investigate the material frictional response under either quasistatic or fast-dynamic contact solicitations. While carbon-fiber-reinforced material exhibits a stable but low friction coefficient, the glass-fiber-reinforced material leads to the suitable combination of high friction and low wear. The PPS material, 40% (wt) glass-reinforced polymer, sliding against the Ti6Al4V titanium alloy, provided high static friction coefficients (>0.4). The same material pair was then tested in endurance under fast-dynamic contact solicitations, highlighting their resistance to wear.
Synthesis of Castor Oil-Based Quaternary Ammonium Salt and Modification of Attapulgite for Treating Industrial Wastewaters
Authors: Yan Xiuhua , Ding Jianfei , Shi Wenyan , Tang Lanqin , Zhang Yidong , Xu Wei
Published: May 2023

In order to develop multifunctional quaternary ammonium salts and explore their advantages as modifiers for wastewater treatment, castor oil-based quaternary ammonium salts were synthesised and subsequently used as modifiers for attapulgite treatment. The structures of untreated and treated attapulgite were compared by Fourier transform infrared spectra and X-ray diffraction. The mechanism of modification was speculated. Various factors such as the amount of modified attapulgite, temperature and pH were also investigated in the batch experiments on the removal rates of acetone and phenol from wastewaters. The synthesis conditions were set as follows: the reaction temperature was 80 °C, the reaction time was 8 h, the molar ratio of castor oil to N,N-dimethyl-1,3-propanediamine was 1:5, the catalyst was 6% NaOH and the product yield was about 64.72%. The grafting rate of the castor oil-based quaternary ammonium salt was about 99.6% when the amount of modifier was 0.69 g per 5 g of attapulgite, the ultrasound treatment time was 11 min and the pH was 5. The quaternary ammonium salt was only associated with the surface of attapulgite and did not change the rod-like crystal structure of the silicate. The modified attapulgite is much more fibrous and exhibits a good distribution of crystal bundles. The removal rates were found to be less favourable under strongly acidic and strongly alkaline conditions. Under suitable conditions, for 50 mL industrial wastewaters (phenol: 100–160 mg/L; acetone: 680–800 mg/L), the amount of modified attapulgite was 1 g, the temperature was 80 °C and the pH was 7, and the maximum removal rates of acetone and phenol after 80 min reached about 65.71% and 78.72%, respectively, which were higher than those of ATP.
Thermal-Related Stress–Strain Behavior of Alkali Activated Slag Concretes under Compression
Authors: Zhang Miao , Ma Qianmin , Chen Yang , Liu Zhuo , Zhou Haoxue
Published: May 2023

In this paper, the thermal-related stress–strain behavior of alkali-activated slag (AAS) concretes, with different alkali concentrations and moduli, was studied under compression. After exposure to high temperatures (200 °C, 400 °C, 600 °C, 800 °C, and 1000 °C), a compression test was carried out on the specimens. The stress–strain relationship, axial compressive strength, and elastic modulus were expressed using both a displacement extensometer and the digital image correlation (DIC) technique. It was mainly determined that: (1) With the increase in temperature, the stress–strain curves of the AAS concretes tended to be flattened, indicating reductions in both axial compressive strength and elastic modulus. After 1000 °C, only 2.5–3.7% axial compressive strength and 1.4–3.9% elastic modulus remained, respectively. (2) The DIC technique was used for thermal strain measurements of the AAS concrete. Compared to the traditional extensometer, DIC yielded a small error of 4.5% and 7.2% for axial compressive strength and elastic modulus measurements, respectively. The strain cloud chart obtained from DIC was helpful for monitoring the damage process of the specimens. The findings of this paper refined scientific systems of AAS concrete under thermal action, and also provided a newly non-contact approach for thermal strain measurements of AAS concrete under compression.
GAM: General Auxetic Metamaterial with Tunable 3D Auxetic Behavior Using the Same Unit Cell Boundary Connectivity
Authors: Ben-Yelun Ismael , Gómez-Carano Guillermo , San Millán Francisco J. , Sanz Miguel Ángel , Montáns Francisco Javier , Saucedo-Mora Luis
Published: May 2023

Research on auxetic metamaterials is important due to their high performance against impact loadings and their usefulness in actuators, among other applications. These metamaterials offer a negative Poisson’s ratio at the macro level. However, usual auxetic metamaterials face challenges in (1) grading the effect, (2) coupling and combining auxetic metamaterials with non-auxetic materials due to boundary compatibility, (3) obtaining the same auxetic behavior in all directions in the transverse plane, and (4) adapting the regular geometry to the component design boundary and shape. The goal of this paper is to present a novel, recently patented tunable 3D metamaterial created to reproduce a wide spectrum of 3D auxetic and non-auxetic Poisson’s ratios and Young’s moduli. This wide range is obtained using the same basic unit cell geometry and boundary connections with neighboring cells, facilitating designs using functionally graded metamaterials as only the connectivity and position of the cell’s internal nodes are modified. Based on simple spatial triangularization, the metamaterial is easily scalable and better accommodates spatial curvatures or boundaries by changing the locations of nodes and lengths of bars.
Model of a 3D Magnetic Permeability Tensor Considering Rotation and Saturation States in Materials with Axial Anisotropy
Authors: Kopala Dominika , Ostaszewska-Liżewska Anna , Råback Peter , Szewczyk Roman
Published: May 2023

The paper proposes a 3D extension of the linear tensor model of magnetic permeability for axially anisotropic materials. In the proposed model, all phases of a magnetization process are considered: linear magnetization, magnetization rotation, and magnetic saturation. The model of the magnetization rotation process is based on the analyses of both anisotropic energy and magnetostatic energy, which directly connect the proposed description with physical phenomena occurring during a magnetization process. The proposed model was validated on the base of previously presented experimental characteristics. The presented extension of the tensor description of magnetic permeability enables the modelling of inductive devices with cores made of anisotropic magnetic materials and the modelling of magnetic cores subjected to mechanical stresses. It is especially suitable for finite element modelling of the devices working in a magnetic saturation state, such as fluxgate sensors.
Review of Geopolymer Nanocomposites: Novel Materials for Sustainable Development
Authors: Drabczyk Anna , Kudłacik-Kramarczyk Sonia , Korniejenko Kinga , Figiela Beata , Furtos Gabriel
Published: May 2023

The demand for geopolymer materials is constantly growing. This, in turn, translates into an increasing number of studies aimed at developing new approaches to the methodology of geopolymer synthesis. The range of potential applications of geopolymers can be increased by improving the properties of the components. Future directions of studies on geopolymer materials aim at developing geopolymers showing excellent mechanical properties but also demonstrating significant improvement in thermal, magnetic, or sorption characteristics. Additionally, the current efforts focus not only on the materials’ properties but also on obtaining them as a result of environment-friendly approaches performed in line with circular economy assumptions. Scientists look for smart and economical solutions such that a small amount of the modifier will translate into a significant improvement in functional properties. Thus, special attention is paid to the application of nanomaterials. This article presents selected nanoparticles incorporated into geopolymer matrices, including carbon nanotubes, graphene, nanosilica, and titanium dioxide. The review was prepared employing scientific databases, with particular attention given to studies on geopolymer nanocomposites. The purpose of this review article is to discuss geopolymer nanocomposites in the context of a sustainable development approach. Importantly, the main focus is on the influence of these nanomaterials on the physicochemical properties of geopolymer nanocomposites. Such a combination of geopolymer technology and nanotechnology seems to be promising in terms of preparation of nanocomposites with a variety of potential uses.
LDH-Based “Smart” Films for Corrosion Sensing and Protection
Authors: Zhao Xuejie , Yuan Yujie , Wei Yuankun , Zhang Zhe , Zhang You
Published: May 2023

In a “smart” corrosion-protective coating system, both the active anti-corrosion and the early corrosion detection of underlying metals are highly required. It is practical significant to develop materials that possess self-detecting of the early local corrosion and self-healing of coating defects simultaneously. The organic compound 8-hydroxyquinoline (8HQ) is an effective inhibitor and a fluorescent sensor probe for corrosion of aluminum alloy. Therefore, a layer double hydroxide (LDH) nanocontainer film loaded with the 8HQ was developed for the active corrosion protection purpose of aluminum alloy AA2024. In corrosive environments, the 8HQ are released from LDH film to inhibit the corrosion process, leading to the loss of the complexation with Al3+ ions in LDH laminates, thus turning off fluorescence. Results show that the LDH film loaded with 8HQ composites can improve the anti-corrosion performance of the film by releasing corrosion inhibitors on demand. Simultaneously, due to the complexation of 8HQ and Al3+ ions, the LDH film is fluorescent at the initial stage under ultraviolet light, and then becomes non-fluorescent at the corrosion sites, indicating the corrosion evolution process of the coating. The 8HQ-loaded LDH film with self-healing and self-detecting dual functions provides promising opportunities for the effective corrosion protection of aluminum alloy due to its “smart” and multifunctional properties.
The Profiling of Hob Mill Used for Generating a Cycloidal Reducer’s Disk
Authors: Moroșanu Georgiana-Alexandra , Teodor Virgil Gabriel , Baroiu Nicușor
Published: May 2023

This paper presents the profiling of the hob mill designed to generate the active surface of the cam of a cycloidal reducer. The algorithm allows determining the active surface of the generating rack gear, which is reciprocally enveloping with the active surface of the cycloidal disk. The novelty of the algorithm, based on the determination of the intermediate surface, consists in the fact that an innovative method of determining this surface is used, called the “virtual pole” method. The method allows determining the enwrapping curve of an ordered curl of surfaces, generated in the rolling movement of two conjugated centrodes. Using the “virtual pole” method, the calculation time for tool profiling is significantly reduced and the disadvantage of the resulting error, small enough to be neglected from a technical point of view, is fully compensated by this reduction in calculation time.
Simulation and Experimental Study on Jetting Projectile Charge Penetrating Multi-Layer Spaced Targets with Large Spacing
Authors: Ji Long , Jia Xin , Guo Jiahui , Cai You’er , Wang Ping , Huang Zhengxiang
Published: May 2023

To study the ability of shaped charges to penetrate typical ship targets, two shaped charges with the same diameter of 200 mm but different configurations are designed to generate two forms of jetting projectile charge (JPC). Based on the protective structure of typical ship targets, static penetration tests are performed using the two types of a shaped charge with copper liner and 10-layer spaced targets with a total span of 16 m which is made in 921A steel. Numerical simulations under the same working conditions are also carried out. It is found that the simulation results of the penetration depth and the number of layers of target perforated by the JPC are much greater than the experimental results. In fact, the JPC breaks up when moving to a certain distance, and the JPC segments after breakup have a transverse drift velocity, causing the segment to deviate from the original penetrating channel. The influence of drift velocity after JPC fracture cannot be considered in numerical simulation, resulting in significant differences between numerical simulation and experimental results. Thus, this paper proposed a segment-based numerical simulation method and analyzed the penetration process of JPC fragments after JPC fracture. Combined with experimental results, the radial motion after JPC fracture and the final distribution of penetration holes can be well revealed. It is found that the penetration depth and the number of layers of target perforated by the JPC depend on the tip velocity of each segment and the jet length.
Linking Transformation and Problem Atomization in Algebraic Problem-Solving
Authors: Lengyelfalusy Tomáš , Gonda Dalibor
Published: May 2023

The transition from arithmetic to algebra requires students to change both their thinking and the way they learn. We often observe students using arithmetic formalism also when solving algebraic problems. This formalism manifests itself primarily in the acquisition of coherent computational procedures. Students must be sufficiently aware that the computation steps are sequential transformations of the problem. This creates a problem for them in solving more complex problems. Our research investigated whether problem transformation coupled with atomization is a suitable alternative for students to learn coherent algorithms. Although atomization is not based on precise rules, it was reported by students to be a comprehensible way of solving problems and providing them with sufficient confidence. If students are motivated to understand a computational method, this understanding represents fulfilling the student’s need for security.