bluuebunny/crossref_metadata_2025 huggingface dataset:
Presentation, surgical outcome, and supplementary motor area syndrome risk of posterior superior frontal gyrus tumors
Authors: Bauman Megan M. J. , Jusue-Torres Ignacio , White Jaclyn J. , Bouchal Samantha M. , Hsu Andrea R. , Ha Yooree , Pumford Andrew D. , Hong Sukwoo , Riviere-Cazaux Cecile , Wang Kimberly , Brown Desmond A. , Helal Ahmed , Parney Ian F.
Published: August 2024

OBJECTIVE

Following resection of posterior superior frontal gyrus (PSFG) tumors, patients can experience supplementary motor area (SMA) syndrome consisting of contralateral hemiapraxia and/or speech apraxia. Given the heterogeneity of PSFG tumors, the authors sought to determine the risk of postoperative deficits and assess predictors of outcomes for all intraparenchymal PSFG tumors undergoing surgery (biopsy or resection), regardless of histology.

METHODS

This was a retrospective single-center cohort study of adult PSFG-region tumors undergoing biopsy or resection by a single surgeon.

RESULTS

A total of 106 consecutive patients undergoing 123 procedures (21 biopsies, 102 resections) fulfilled inclusion and exclusion criteria. Anaplastic astrocytomas were the most frequent among resected tumors (39% vs 29%), while glioblastomas were most common among biopsies (38% vs 27%) (p < 0.0001). The biopsy cohort was more likely to have tumor involvement outside the PSFG (90% vs 62%) (p = 0.011), most commonly in the motor cortex (67% vs 31%) (p = 0.005). Seizures were the most common presenting symptom in the resection cohort (p = 0.017), while motor deficits were more common in the biopsy cohort (58% vs 29%) (p < 0.001). Immediate postoperative neurological deficits occurred in 71 cases (58%), but only 3 of the deficits were permanent at 6 months of follow-up (2%). Postoperative SMA syndrome occurred in 48 cases (47%) and was significantly associated with involvement of the motor cortex (p = 0.018) or cingulate gyrus (p = 0.023), which were also significant in multivariate analysis as risk factors for SMA syndrome. However, postoperative SMA syndrome was not significantly associated with overall survival (p = 0.51). There were no perioperative deaths, but corpus callosum involvement (p < 0.001), contrast enhancement (p = 0.003), and glioblastoma pathology (p = 0.038) predicted worse overall survival in patients undergoing resection.

CONCLUSIONS

Nearly half of all patients undergoing resection of PSFG-region tumors experience a postoperative SMA syndrome. Individuals with corpus callosum and/or motor cortex involvement may be at an increased risk of experiencing SMA syndrome. However, these deficits are usually transient, and the risk of permanent new deficits is very low (3%). Preoperative characteristics including corpus callosum involvement and tumor enhancement—in addition to pathology—might serve as predictors of overall survival within this patient population.
Long-term survivors in 976 supratentorial glioblastoma, IDH-wildtype patients
Authors: Aboubakr Oumaima , Moiraghi Alessandro , Elia Angela , Tauziede-Espariat Arnault , Roux Alexandre , Leclerc Arthur , Planet Martin , Bedioui Aziz , Simboli Giorgia Antonia , Dhermain Frédéric , Parraga Eduardo , Benevello Chiara , Fathallah Houssem , Muto Jun , Chrétien Fabrice , Dezamis Edouard , Oppenheim Catherine , Varlet Pascale , Zanello Marc , Pallud Johan
Published: August 2024

OBJECTIVE

Glioblastoma, isocitrate dehydrogenase (IDH)–wildtype is the most aggressive glioma with poor outcomes. The authors explored survival rates and factors associated with long-term survival in patients harboring a glioblastoma, IDH-wildtype.

METHODS

In an observational, retrospective, single-center study, the authors examined the medical records of 976 adults newly diagnosed with supratentorial glioblastomas, IDH-wildtype between January 2000 and January 2021. They analyzed clinical-, imaging-, and treatment-related factors associated with 2-year and 5-year survival.

RESULTS

The median overall survival was 11.2 months (12.2 months for patients included after 2005 and the introduction of standard combined chemoradiotherapy). The median progression-free survival was 9.4 months (10.0 months for patients included after 2005). Overall, 17.6% of patients reached a 2-year overall survival, while 2.2% of patients reached a 5-year overall survival. Furthermore, 6.6% of patients survived 2 years without progression, while 1.1% of patients survived 5 years without progression. Two factors that were consistently associated with 2-year and 5-year survival were first-line oncological treatment with standard combined chemoradiotherapy and methylated O6-methylguanine-DNA methyltransferase promoter. Other factors that were significantly associated with 2-year or 5-year survival were age at diagnosis ≤ 60 years, headaches or signs of raised intracranial pressure at diagnosis, cortical contact of contrast enhancement, no contrast enhancement crossing the midline on initial imaging, total or subtotal tumor resection, and a second line of oncological treatment at recurrence. Within 21 cases of 5-year survival, 18 were confirmed to be glioblastomas, IDH-wildtype, and 7 of the 5-year survivors (38.9%) had additional genetic alterations: 3 cases had an FGFR mutation or fusion, 3 cases had a PIK3CA mutation, 1 case had a PTPN11 mutation, and 1 case had a PMS2 mutation in the context of constitutional mismatch repair deficiency syndrome.

CONCLUSIONS

Five-year overall survival in patients with glioblastoma, IDH-wildtype is extremely low. Predictors of a longer survival are mostly treatment factors, emphasizing the importance of a complete oncological treatment plan, when achievable. Glioblastoma, IDH-wildtype 5-year survivors could be screened for actionable targets in case of recurrence.
Clinicogenomic predictors of survival and intracranial progression after stereotactic radiosurgery for colorectal cancer brain metastases
Authors: Gui Chengcheng , Walch Henry S. , Mueller Kirin D. , Boe Lillian A. , Ilica A. Turan , Strong James , Eichholz Jordan E. , Yu Kenny K. H. , Wilcox Jessica A. , Manca Paolo , Yu Yao , Yamada Yoshiya , Imber Brandon S. , Maron Steven B. , Foote Michael B. , Yaeger Rona , Schultz Nikolaus , Pike Luke R. G.
Published: August 2024

OBJECTIVE

Brain metastases (BM) from colorectal cancer (CRC) are associated with dismal prognosis. When BM-directed therapy is considered, better methods are needed to identify patients at risk of poor oncological outcomes in order to optimize patient selection for closer surveillance or escalated therapy. The authors sought to identify clinicogenomic predictors of survival and intracranial disease progression after CRC BM have been treated with stereotactic radiosurgery (SRS).

METHODS

Patients with newly diagnosed CRC BM treated with SRS between 2009 and 2022 who had next-generation genomic sequencing data available were included. Frameless SRS was delivered in 1–5 fractions, alone or after neurosurgical resection. Outcomes included overall survival (OS) and intracranial progression (IP), evaluated per patient treated with SRS, and local progression (LP), evaluated per BM. Associations between baseline clinicogenomic features and outcomes were evaluated with Cox regression and competing risk regression, with death as a competing risk.

RESULTS

This analysis included 123 patients with 299 BM. At BM diagnosis, 111 patients (90%) had progressive extracranial disease, and 79 patients (64%) had ≥ 3 sites of extracranial metastasis. The median (IQR) number of BM was 2 (1–3) per patient. The median (IQR) biologically effective dose (BED) was 51.3 (51.3–65.1) Gy, corresponding to a prescription of 27 Gy in 3 fractions. OS, IP, and LP estimates at 1 year after SRS were 36%, 55%, and 12%, respectively. OS was independently associated with progressive extracranial disease (HR 4.26, 95% CI 1.63–11.2, p = 0.003) and ≥ 3 extracranial metastatic sites (HR 1.84, 95% CI 1.12–3.01, p = 0.02). LP was less likely when BM received BED ≥ 51.3 Gy (HR 0.24, 95% CI 0.07–0.78, p = 0.02), independent of BM diameter (HR 1.21/cm, 95% CI 0.8–1.84, p = 0.4). IP was independently associated with genomic alterations; TP53 driver alterations were associated with higher risk of IP (HR 2.71, 95% CI 1.26–5.79, p = 0.01), whereas MYC pathway alterations were associated with lower risk (HR 0.15, 95% CI 0.03–0.68, p = 0.01).

CONCLUSIONS

The authors identified clinicogenomic features associated with adverse outcomes after SRS for CRC BM. Progressive and extensive extracranial metastases predicted worse OS. Insufficient SRS doses predicted greater risk of LP. Wild-type TP53 and alterations in the MYC pathway were independently associated with lower risk of IP. Patients at high risk of IP may be considered for closer surveillance or escalated therapy.
Predictors of patient satisfaction after surgery for grade 1 degenerative spondylolisthesis: a 5-year analysis of the Quality Outcomes Database
Authors: Dru Alexander , Johnson Sarah E. , Linzey Joseph R. , Foley Kevin T. , Digiorgio Anthony , Alan Nima , Coric Domagoj , Potts Eric A. , Bisson Erica F. , Knightly John J. , Fu Kai-Ming , Shaffrey Mark E. , Weaver Jason , Bydon Mohamad , Chou Dean , Meyer Scott A. , Asher Anthony L. , Shaffrey Christopher I. , Slotkin Jonathan R. , Wang Michael Y. , Haid Regis W. , Glassman Steven D. , Virk Michael S. , Mummaneni Praveen V. , Park Paul
Published: August 2024

OBJECTIVE

Lumbar decompression and/or fusion surgery is a common operation for symptomatic lumbar spondylolisthesis refractory to conservative management. Multiyear follow-up of patient outcomes can be difficult to obtain but allows for identification of preoperative patient characteristics associated with durable pain relief, improved functional outcome, and higher patient satisfaction.

METHODS

A query of the Quality Outcomes Database (QOD) low-grade spondylolisthesis module for patients who underwent surgery for grade 1 lumbar spondylolisthesis (from July 2014 to June 2016 at the 12 highest-enrolling sites) was used to identify patient satisfaction, as measured with the North American Spine Society (NASS) questionnaire, which uses a scale of 1–4. Patients were considered satisfied if they had a score ≤ 2. Multivariable logistic regression was performed to identify baseline demographic and clinical predictors of long-term satisfaction 5 years after surgery.

RESULTS

Of 573 eligible patients from a cohort of 608, patient satisfaction data were available for 81.2%. Satisfaction (NASS score of 1 or 2) was reported by 389 patients (83.7%) at 5-year follow-up. Satisfied patients were predominantly White and ambulation independent and had lower baseline BMI, lower back pain levels, lower Oswestry Disability Index (ODI) scores, and greater EQ-5D index scores at baseline when compared to the unsatisfied group. No significant differences in reoperation rates between groups were reported at 5 years. On multivariate analysis, patients who were independently ambulating at baseline had greater odds of long-term satisfaction (OR 1.12, p = 0.04). Patients who had higher 5-year ODI scores (OR 0.99, p < 0.01) and were uninsured (OR 0.43, p = 0.01) were less likely to report long-term satisfaction.

CONCLUSIONS

Lumbar surgery for the treatment of grade 1 spondylolisthesis can provide lasting pain relief with high patient satisfaction. Baseline independent ambulation is associated with a higher long-term satisfaction rate after surgery. Higher ODI scores at 5-year follow-up and uninsured status are associated with lower postoperative long-term satisfaction.
Durability of substantial clinical benefit leading to optimal outcomes in adult spinal deformity corrective surgery: a minimum 5-year analysis
Authors: Mir Jamshaid M. , Galetta Matthew S. , Alan Nima , Onafowokan Oluwatobi O. , Das Ankita , Dave Pooja , Tretiakov Peter , Lorentz Nathan A. , Lafage Renaud , Diebo Bassel , Janjua M. Burhan , Chou Dean , Smith Justin S. , Lafage Virginie , Schoenfeld Andrew J. , Sciubba Daniel , Demetriades Andreas K. , Passias Peter G.
Published: August 2024

OBJECTIVE

The objective was to evaluate factors associated with the long-term durability of outcomes in adult spinal deformity (ASD) patients.

METHODS

Operative ASD patients fused from at least L1 to the sacrum with baseline (BL) to 5-year (5Y) follow-up were included. Substantial clinical benefit (SCB) in Oswestry Disability Index (ODI), numeric rating scale (NRS)–back, NRS-leg, and Scoliosis Research Society (SRS)–22r scores and physical component score were assessed on the basis of previously published values. Factors were evaluated on the basis of meeting optimal outcomes (OO) at 2 years (2+) and 5 years (5+). Furthermore, 2+ patients were isolated and evaluated on the basis of meeting OO at 5 years (2+5+) or not at 5 years (2+5−). OO were defined as follows: no reoperation, major mechanical failure, proximal junctional failure, and meeting either 1) SCB in terms of ODI score (decrease > 18.8) or 2) ODI < 15 and SRS-22r total > 4.5.

RESULTS

In total, 330 ASD patients met the inclusion criteria, with 45.5% meeting SCB for ODI at 2 years, while 46.0% met SCB at 5 years; 79% of those who achieved 2-year (2Y) SCB went on to achieve 5Y SCB. This rate was lower for OO, with 41% achieving 2Y OO (2+), while 37% met 5Y OO (5+) and 80% of 2+ patients had durable outcomes until 5+ (32% of the total cohort). Of the patient factors, frailty was significantly different among groups at 2 years, while comorbidity burden was significantly different at 5 years and the combination thereof differed in those with durable outcomes. Those who regained their level of activity postoperatively had 4 times higher odds of maintaining OO from 2 years to 5 years (p < 0.05). Osteoporosis rates, although equivocal at BL, were higher at the last follow-up in those who met 2Y OO but failed to meet 5Y OO. The odds of achieving OO at 5 years in 2+ patients decreased by 47% for each additional comorbidity and decreased by 74% in those who had lower-extremity paresthesias at BL (both p < 0.05). Controlling for patient factors and BL disability found fewer levels fused, decreased correction of sagittal vertical axis, and increased correction of pelvic incidence–lumbar lordosis mismatch to be predictive of maintaining 2Y OO until 5 years (p < 0.05).

CONCLUSIONS

SCB was met in 46% of ASD patients at 5 years. The durability of OO was seen in a third of patients until 5 years postoperatively. Higher rates of medical complications were seen in those who failed to achieve and maintain OO until 5 years. Frailty and comorbidity burden were significant factors associated with the achievement and durability of OO until 5 years.
Stereotactic radiosurgery for intracranial dural arteriovenous fistulas: patient outcomes and lessons learned over a 3-decade single-center experience
Authors: Peters Pierce A. , Naylor Ryan M. , Lanzino Giuseppe , Link Michael J. , Pollock Bruce E.
Published: August 2024

OBJECTIVE

The role of stereotactic radiosurgery (SRS) in the management of intracranial dural arteriovenous fistula (dAVF) is unclear given the rarity of this lesion and the variability in treatment paradigms. This study describes a 3-decade experience with the SRS technique and its outcomes for patients with dAVF.

METHODS

The authors conducted a retrospective analysis of patients with dAVF who had undergone single-fraction SRS in the period from 1990 to 2021. The imaging modality initially used for targeting was angiography alone, then angiography plus MRI, and most recently MRI alone.

RESULTS

Two hundred twenty-two patients underwent SRS alone (n = 56, 25%) or SRS plus embolization (n = 166, 75%), depending on the severity of symptoms or the presence of cortical venous drainage (CVD). Most patients were women (64%), and the median patient age was 60 years. Common presenting symptoms were pulsatile bruit (55%), visual change or chemosis (21%), headache (10%), and intracerebral hemorrhage (5%). The most frequent dAVF location was the transverse or sigmoid sinus (44%), followed by the cavernous sinus (24%), jugular bulb (9%), and torcula (5%). CVD was noted in 28% of cases, and venous ectasia in 5%. Borden dAVF types among the patients were I (72%), II (20%), and III (8%). Cognard dAVF types among the patients were I (44%), IIa (27%), IIb (5%), IIa+b (15%), III (4%), and IV (5%).

The median SRS treatment volume was 7.6 cm3; the median margin and maximum doses were 18 and 36 Gy, respectively. Follow-up after SRS was available for 209 patients (median follow-up 31 months). Obliteration was noted in 75% of the patients (110/147) with follow-up vascular imaging; the median time to obliteration was 37 months. Multivariate analysis revealed that a cavernous sinus dAVF location was predictive of radiological obliteration (HR 1.86, 95% CI 1.08–3.18, p = 0.024). The absence of CVD was predictive of obliteration in subgroup analysis of non–cavernous sinus dAVF (HR 0.53, 95% CI 0.29–0.98, p = 0.04). Symptoms resolved in 86% of patients (160/185) with clinical follow-up. Twelve patients (5.4%) had complications related to angiography for SRS planning (n = 2, 0.9%), embolization (n = 3, 1.4%), post-SRS hemorrhage (n = 1, 0.5%), delayed sinus thrombosis (n = 1, 0.5%), radiation-induced tumors (n = 2, 0.9%), and chronic encapsulated expanding hematoma (n = 3, 1.4%).

CONCLUSIONS

SRS alone or in conjunction with embolization provided obliteration and symptom relief for the majority of patients with dAVF, with a low rate of procedure-related morbidity. Patients are at risk for late radiation-related complications, which can require treatment many years after SRS.
Implementasi Penggunaan Peta Konsep dalam Meningkatkan Pemahaman Mahasiswa tentang Statistika Pendidikan
Authors: Solehah Azmiatun , Sahraini Alfiana , Abdillah Abdillah
Published: August 2024

Abstrak: Penelitian ini bertujuan untuk mengeksplorasi efektivitas implementasi peta konsep dalam meningkatkan pemahaman mahasiswa terhadap statistika pendidikan. Metode penelitian yang digunakan adalah kuantitatif deskriptif dengan melibatkan 44 mahasiswa sebagai subjek penelitian. Instrumen penelitian yang digunakan meliputi lembar penilaian peta konsep serta observasi di dalam kelas untuk memperoleh data yang komprehensif. Analisis data dilakukan menggunakan uji-t untuk mengukur hubungan antara implementasi peta konsep dan peningkatan pemahaman mahasiswa terhadap statistika pendidikan. Hasil analisis menunjukkan adanya nilai korelasi yang signifikan sebesar 22.268 dengan nilai signifikansi 0.000. Temuan ini menunjukkan bahwa penggunaan peta konsep dapat memberikan kontribusi yang signifikan dalam meningkatkan pemahaman mahasiswa terhadap materi statistika pendidikan. Penelitian ini memberikan pemahaman yang lebih dalam tentang manfaat peta konsep dalam konteks pembelajaran statistika pendidikan di lingkungan akademik. Implikasi dari hasil penelitian ini dapat menjadi landasan bagi pengembangan strategi pembelajaran yang lebih efektif dalam meningkatkan pemahaman mahasiswa terhadap mata kuliah statistika pendidikan. Penelitian lanjutan dapat dilakukan untuk mengeksplorasi lebih lanjut faktor-faktor lain yang memengaruhi efektivitas penggunaan peta konsep dalam pembelajaran.Abstract: The study aims to explore the effectiveness of implementing concept maps in enhancing students' understanding of educational statistics. A quantitative descriptive method was utilized involving 44 students as research subjects. Research instruments included concept map assessment sheets and classroom observations to obtain comprehensive data. Data analysis was conducted using t-tests to measure the relationship between concept map implementation and the improvement of students' understanding of educational statistics. The analysis results indicated a significant correlation value of 22.268 with a significance value of 0.000. These findings suggest that the use of concept maps can significantly contribute to enhancing students' understanding of educational statistics material. This research provides a deeper understanding of the benefits of concept maps in the context of educational statistics learning in academic settings. The implications of these research findings can serve as a basis for developing more effective learning strategies to enhance students' understanding of educational statistics courses. Further research could explore other factors influencing the effectiveness of concept map utilization in learning.
The Effect of Maturity Quality of Kepok Banana on the Sweetness Level of Banana Sale
Authors: Hafiz Muhammad Haikal , Tanggasari Devi
Published: August 2024

One of the preparations that can be made with the basic ingredients of kepok bananas is banana sale. Processed banana sale in this study used three levels of banana ripeness, namely greenish yellow, shiny yellow, and brownish yellow with black spots. The purpose of this study was to determine the reduction in mass in the manufacture of sale bananas, to determine the level of sweetness of sale bananas from three different maturity levels, to determine the drying time of bananas from different maturity levels with various water content, and to determine the preference level of the three maturity levels. banana sale. The method used is the RAK method (Completely Randomized Design) and using SPSS software. The analysis was carried out on the level of sweetness, preference, and water content. The results showed that the water content at the maturity level of greenish yellow was 17.66%, the maturity level for shiny yellow was 17.33% and the maturity level was brownish yellow with black spots was 18%. The sweetness level of greenish yellow bananas is 13.66%, the maturity level is shiny yellow is 28.33%, the maturity level is brownish yellow with black spots is 29.66%. The higher the maturity level of the banana, the higher the level of sweetness of the banana. From the results of the preference level of sale bananas from the maturity level of greenish yellow, shiny yellow and brownish yellow with black spots, the preferred level of preference is the maturity level of shiny yellow.
The Role of Internal Memory to Enhance The Vocabulary By Using Word Wall
Authors:   Universitas Muhammadiyah Parepare, Sandi Sandi , Rahman Ali Wira
Published: August 2024

This research is based on the students’ problem regards English especially on vocabulary. Vocabulary is the important thing for students in the process of acquiring, learning, mastering, and using the language they learn. Without having vocabulary nothing can be convey. Mastering vocabulary will help the students to communicate easier with other people. Those reason become some of the considerations of the researcher to conduct a research when doing an observation at SMK Bahari Parepare because the students showed their limited of vocabulary. Then, modifying the method could be the problem solving for the limited vocabulary. in this case, the implementation of word wall as an media was suggested to overcome the problem. Finally, this research was intended to reveal that: can the role of internal memory by using word wall improve the vocabulary of the eleventh grade students of SMK Bahari Parepare significantly. This research used quasi experimental method, with two group pre-test and post-test design. The population was the eleventh grade students of SMK Bahari Parepare. The samples were drawn by using random sampling technique that consisted of 45 students which were class XI Teknika A as experimental class and class XI Nautika as control class. The data were acquired by using vocabulary test. The vocabulary mastery test was applied in the pre-test and post-test. The data required from vocabulary test was analyzed by using ttest and percentage technique. The result of the data analysis showed that the students’ vocabulary mastery improved significantly. It was showed by the mean score of the pretest was (56.19) and the post-test was (76.904). It showed that word wall can improve vocabulary of the eleventh grade students of SMK Bahari Parepare significantly. Besides, the mean score of the students in post-test (76.904) was higher than the standard scoring Departemen Pendidikan Nasional Republik Indonesia (70.00). After analyzing the data by using the t-test formula, the result of t-test value in post-test was (2.147) and t-table value was (2.021). Those indicated that H1 was accepted and H0 was rejected. It meant that word wall can improve vocabulary of the eleventh grade students of SMK Bahari Parepare significantly.
Implementing Multiple Intellegence Approach To Improve The Speaking Ability of The Eight Grade Students of SMP Negeri 3 Duampanua
Authors: Muliani  , Ammang Latifa  , Rafi'ah Nur
Published: August 2024

The major problems of this research were how to enhance the students’ speaking ability. Then how to motivate the students to speak in English so this research conducted to find out whether implementing Multiple Intelligence effective to improve the students’ speaking of SMP Negeri 3 Duampanua.
A quasi-experimental method was carried out by researcher in this research. The population was the eight grade students of SMP Negeri 3 Duampanua. VIII.1 and VIII.2  were taken as sample which consists of 25 students for each class VIII.1 was chosen as the experimntal class, while VIII.2 was chosen as the control class. The instruments that used in collecting the data were interview test and questionnaire. The procedure in collecting data were divided into 3 stages namely pre-test, treatment, and post-test. The data obtained through the test were analyzed quantitatively and qualitatively.
            The result of the research shows the students’ speaking ability of the experimental was better than the control group. It was proved by the data of the students’ mean score on experimental class was higher tha the control group (69.16 ˃ 60.52). Futhermore, implementing multiple intelligence  improve the student speaking ability. Besides, the research finding also shows the students interest toward the implementing of this simulation. It was proved by the data from questionnaire that the students’ interest was which categorized as strongly agree.
Implementing of Think-Pair-Share In Teaching Speaking Ability to The Seventh Grade Students of SMP Negeri 9 Parepare
Authors: Abd. Wahid
Published: August 2024

This research was based on the students’ problem regarding the English teaching, especially in speaking in the classroom. Which is the teacher was more active rather than students in learning process. Therefore, the objective of this research is to find out whether or not the speaking ability improves to the seventh-grade students of SMP Negeri 9 Parepare before and after given taught by implementing think-pair-shar as strategy. This researcher applied quasi-experimental design, with two group pre-test and post-test design. The population of this research was seventh grade students of SMP Negeri 9 Parepare. Total number of population was 112 students and was taken as sample by using cluster random sampling technique, class VII.1 as experimental class and class VII.4 as control class. the number of each class was 63 students. The material in this research were about descriptive text to know the student’s ability in the application of think-pair-share as strategy in teaching speaking. The researcher reveals that there is significant difference between experimental class and control class, that indicated from the mean score of the experimental class is 53,56 in pre-test to 70,90 in post-test, while that of the control class is 46,19 in pre-test to 61,25 in post-test. It is concluded that speaking ability can improve by implemented of think-pair-share.
Improving The Writing Ability of The Tenth Year Students of SMK Negeri 3 Parepare Through Story Pyramid Strategy
Authors: Yuslinda Yusup
Published: August 2024

One of the four English skills which were not taught well at Vocational High School was writing, the students were difficult to write. Based on the researcher’s observation, there were many students who have difficulties in writing. It was proved by the students’ writing score was in fair classification. There were several problems faced by students such as students’ writing was not comprehensible and there were still many errors in vocabulary, grammar, and spelling. Therefore, the researcher intended to help students to overcome their writing difficulties by using story pyramid strategy. This was a good strategy help students to organize their idea or plans before they write a complete paragraph. The objective of the research was to find out whether or not the use of story pyramid strategy can improve the writing ability of the tenth year students of SMKN 3 Parepare. The researcher applied quasi-experimental design with two group pre-test and post-test design. There were two variables; they were independent variable and dependent variable. The samples of the research consisted of 62 students from two classes taken from population of the tenth year students of SMKN 3 Parepare. Class X MM 2 as experimental class and X TKJ 2 as control class. The instrument used in this research was writing test. The result of the data analysis showed that the students’ writing ability improved significantly. It was showed by the mean score of pre-test was 53.16 and the post-test was 77.03 It showed that the use of story pyramid strategy could improve the students’ writing ability of the tenth year students of SMKN 3 Parepare. Beside the different score of pre-test and post-test, the mean score of the students in post-test was higher than the Criteria of Completeness Maximum (75) in SMKN 3 Parepare. After analyzing the data by using SPSS version 21, the result showed the level of significance (0.05) was higher than t-test result (0.000). Those indicated that H1 was accepted and H0 was rejected.
Improving The Seventh Grade Students’ Vocabulary Mastery at UPTD SMP Negeri 22 Barru by Using Telegram Application
Authors: Yuliati Yuliati , Patahuddin Patahuddin , Patintingan Amir
Published: August 2024

Based on observation, the researcher found that students’ vocabulary mastery relatively low where the big triggers was the learning media used by teacher. So that, the objective of this researcher was to measure whether the use of telegram application can improve the seventh grade students’ vocabulary mastery at UPTD SMP Negeri 22 Barru. In this research the researcher applied quasi-experimental method.The population of this research was the seventh grade students at  UPTD SMP Negeri 22 Barru. The samples of the research taken using cluster random sampling technique, there are two classes as sample, experimental class and control class, both classes consisted of 28 students.The data was collect using vocabulary test (pre-test and post-test) and analyze employ statistical calculation to test the hypothesis. The result of this research shows that the mean score of pre-test was 45.35 and the post-test was 83.57. Besides the different score of pre-test and post-test, the mean score of the students in post-test 83.57 is higher than the Kriteria Ketuntasan Minimal (75) in UPTD SMP Negeri 22 Barru. The result of t-test value in post-test was 2.214 and t-table value was 1.684. It means that H1 was accepted and H0 was rejected and The seventh grade students at UPTD SMP Negeri 22 Barru who are taught by using telegram application is have better vocabulary mastery than the seventh grade students who are taught without using telegram application.
The Soviet experience of achieving the technical & economic independence of the country
Authors: Poberezhnikov I. V. , Artemov E. T.
Published: August 2024

Today, one of the main tasks facing the country is to ensure its technological sovereignty. In the Soviet Union, a similar task (achieving the technical economic independence) was successfully solved during the 1930s – 1960s. Of course, in the current conditions, the Soviet experience cannot serve as a basis for developing practical solutions. Nevertheless, appealing to the past would be useful due to the high inertness of institutional development; the need to understand the logic of long-term changes, the ‘rules of the game’ that have formed in the past; a certain similarity between the world economic situations then and now (a total ban imposed on the transfer of technologies critical for the development of the Soviet economy vs. sanctions pressure on the country today); similarities in the methods and mechanisms for achieving the goal – the creation and development of technologies based on their own scientific technical capabilities.
The article examines the interaction of science, technology and production in the context of the Soviet model of late industrial modernization. The relationship between the high rates of economic growth and raising of scientific technical activities has been substantiated, which included the large-scale researches on the entire frontline of modern science and priority attention to key guidelines of scientific technical progress (atomic project, rocket and space program, creation of the electronics industry, computing technologies). The exceptionally important role of the Academy of Sciences in bringing the Soviet Union to the forefront of scientific and technical positions is also shown. Special attention is paid to the interaction of science and production, the problem of technological transfer from defense industry sectors to civilian ones. The reasons for the slowdown in the pace of scientific technical progress are indicated, which led to the loss of the bygone dynamism of the Soviet economy, which ultimately turned into its crisis.
Neutron physics as a matter of life
On the 90TH anniversary of the birth of academician V.A. Nazarenko
Authors: Baranov I. A. , Voronin V. V. , Ermakov K. N. , Pirozhkov A. N. , Serebrov A. P. , Smolsky S. L. , Fedorov V. V.
Published: August 2024

The article is devoted to the life and work of Vladimir Andreevich Nazarenko (1934–2006), a talented experimental physicist, Winner of the Lenin Prize (1974), Honored Worker of Science and Technology of the Russian Federation, Academician of the Russian Academy of Sciences, director of the Petersburg Nuclear Physics Institute named by B.P. Konstantinov of the Russian Academy of Sciences (1994–2006). Knight of the Order of Honor, Honorary citizen of the city of Gatchina. In addition to remarkable scientific achievements, the undoubted merit of V.A. Nazarenko is convinced that in the most difficult years for Russian science, his efforts played a decisive role in preserving the creative potential of the Institute and its leading positions in the world in many areas of scientific research. From the mid-90s to the end of his life, he was the coordinator of the RAS Physics Science Department Program “Neutron Studies of Substsnce and fundamental properties of Matter”. Having headed the project to create a research complex based on the PIK reactor, V.A. Nazarenko, with his incredible efforts, managed to give a new impetus to the construction of the PIK reactor, which determined the development of the institute and its new prospects for many years to come. As a result, the implementation of a large-scale project is now in the final stage, the authors of the article at various times worked closely with Vladimir Andreevich in various directions.
Ведення пацієнтів із легеневою гіпертензією в умовах воєнного стану: реалії та проблеми
Authors: Radchenko G. D. , Torbas O. O. , Botsiuk Yu. A. , Rekovets O. L. , Progonov S. O. , Sirenko Yu. M.
Published: August 2024

Any military actions on the territory of any country can significantly influence on the quality of medical care. Especially, it could reflect on patients with rare diseases requiring expensive treatment. In this article there were analyzed the work of the specialized pulmonary hypertension (PH) center during the period of Russia’s military invasion in Ukraine and presented the results of the outpatient survey due to problems with patient access to medical care and medicine provision in the period from 24-Feb-2022 to 01-Jul-2024 (war period).We selected patients with a diagnosis of PH carried out for the periods: since 01-Jan-2018 until 30-Apr-2020 (pre-war and pre-COVID-19 period) and since 22-Feb-2022 until 01-Jul-2024 (war period): n=328 and n=394 respectively. The selection was made from the electronic hospital database and the electronic registry of patients that have been conducted in the department since 2014. With the help of the Google Form system, a questionnaire was created and sent through modern devices of communication (Viber, Facebook) to fill out online to patients who are registered (applied for outpatient or inpatient care) in the department or are subscribers to the social network accounts of the Ukrainian Association of Patients with Pulmonary hypertension and/or the Lviv City Charitable Foundation «Sisters of Dalili». We got 220 responses. It was established that martial law status in the country did not significantly affect the management of patients with different forms of PH in the specialized center. The number of treated patients and performed right heart catheterization procedures increased by 20 and 22 % respectively during the «war period», compared to the «pre-war» period. 65 % of PH patients who came abroad due to the war used the help of the specialized department for direct referral to PH centers in Poland for further treatment, including surgical one. 41,7 % of respondents changed their place of residence during the war, but only 17,9 % had interruptions in taking of drugs for the PH treatment. Along with the usual sources of free medicines (humanitarian aid from charitable organizations, the government’s free medicines program), one in five patients «shared out» medicines with other patients. In 45 % of the patients who visited foreign PH centers, the therapy previously prescribed in Ukraine was changed to more effective or safer drugs that are not registered in Ukraine.
Pengaruh Persepsi Kegunaan Dan Persepsi Kemudahan Terhadap Minat Penggunaan Brimo (BRI Mobile) (Pada Pedagang Sembako Di Pasar Tanjung Kabupaten Jember)
Authors:   Program Studi Pendidikan Ekonomi /Jurusan Pendidikan Ilmu Pengetahuan Sosial, Fakultas Keguruan dan Ilmu Pendidikan, Universitas Jember, Indonesia, Salsabila Edwina Nisrina , Ani Hety Mustika ,   Program Studi Pendidikan Ekonomi /Jurusan Pendidikan Ilmu Pengetahuan Sosial, Fakultas Keguruan dan Ilmu Pendidikan, Universitas Jember, Indonesia, Zulianto Mukhamad ,   Program Studi Pendidikan Ekonomi /Jurusan Pendidikan Ilmu Pengetahuan Sosial, Fakultas Keguruan dan Ilmu Pendidikan, Universitas Jember, Indonesia
Published: August 2024

This study aims to analyze the factors that can influence the perception of staple food traders in the Tanjung market about interest in using BRImo through attitude towards using, using the TAM (Technology Acceptance Model) approach. These factors include perceived usefulness, perceived ease of use, and attitude towards using as Intervening variables. This research was conducted by distributing questionnaires to food traders in Tanjung market, Jember regency. Sample determination in this study used the Simple Random Sampling method. The questionnaire was distributed to 109 food traders in Tanjung market who qualified as samples and analyzed using SPSS (Statistical Package for the Social Sciences).The test showed that: (1) perceived usability had a significant effect on interest in use; (2) perceived convenience has a significant effect on interest in use; (3) attitude toward using has a significant effect on interest in use; (4) perceived usefulness of interest through attitude toward using has a significant effect; (5) The perception of ease of interest through attitude toward using does not have a significant effect.
Perubahan Makna dan Simbol Pada Motif Kain Sutera pada kalangan Remaja Bugis di Kabupaten Wajo
Authors: Luran Nurhadelia Fadeli , Tahara Tasrifin , Astuti Sri
Published: August 2024

Penelitian ini bertujuan untuk mengetahui perubahan makna dan simbol motif sutra pada remaja Bugis di Kecamatan Tanasitolo Kabupaten Wajo. Dengan fokus penelitian tentang jenis dan motif kain sutera, pengertian jenis dan motif kain sutera, dan pemanfaatan kain sutera di kalangan pemuda Bugis di Kecamatan Tanasitolo Kabupaten Wajo. Dalam penelitian ini jenis penelitian yang digunakan adalah penelitian deskriptif kualitatif dengan metode etnografi. Teknik penentuan informan dalam penelitian ini menggunakan teknik purposive yang dipilih berdasarkan kriteria yang telah ditentukan. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah observasi dan wawancara mendalam dengan informan. Hasil penelitian ini menunjukkan bahwa terdapat beberapa jenis dan motif kain sutera yang masih bertahan pada masyarakat Bugis, namun perkembangan motif pada kain sutera ini mengikuti perubahan yang terjadi pada masyarakat. Makna yang terkandung dalam kain sutera memiliki makna yang sarat nilai filosofis dan juga mengandung unsur budaya yang memiliki nilai tinggi, namun perubahan cara pandang masyarakat Bugis Wajo menjadi faktor perubahan makna kain sutera. Kegunaan sutera adalah sutera sebagai pakaian, sutera sebagai lambang kedudukan dalam masyarakat, sebagai lambang penghormatan atau persahabatan dan sebagai lambang dalam acara-acara kebudayaan.
Cerita Rakyat di Balik Keindahan Taman Nasional Bantimurung: Sebuah Kajian Folklor
Authors: Yunisa Andi , Pratama I Gede Angga Sastra , Ismail Muh. Reynaldi , Nurdinda Nurdinda , Rumpaidus Aberai Stefanus , Asrar Asrar , Agil Sahwi , Yunus Taufiiqurrahman , Fadhilah Siti Alfiyah
Published: August 2024

Penelitian ini merupakan kajian mengenai Folklor yang beredar di masyarakat Bantimurung dalam latar belakang keindahan wisata Bantimurung, Maros. Penelitian ini fokus pada 4 cerita rakyat yang menjadi bagian integral dan identitas Masyarakat Bantimurung. Metode penelitian ini menggunakan pendekatan kualitatif dengan Teknik wawancara mendalam dan observasi partisipasi untuk mengumpulkan data dari narasumber yang merupakan pemegang pengetahuan tradisional. Wawancara mendalam (in-depth interview), observasi, serta studi literatur pendukung adalah tiga teknik pengumpulan data yang dikombinasikan dalam penelitian ini, guna mengidentifikasi unsur-unsur naratif, tokoh, dan latar cerita, sedangkan analisis makna melibatkan interpretasi simbolik dan pesan terkandung Folklor. Hasil penelitian menunjukkan bahwa struktur cerita rakyat Bantimurung memiliki pola naratif yang khas, dengan toko-toko mitologis yang mencerminkan nilai-nilai etika dan moral Masyarakat. Analisis makna mengungkapkan bahwa setiap elemen dalam Folklor memiliki signifikansi mendalam yang terkait dengan kepercayaan, nilai-nilai, dan norma sosial Masyarakat. Penelitian ini memberikan wawasan lebih lanjut tentang kekayaan budaya Masyarakat Bantimurung melalui interpretasi Folklor mereka. Temuan ini dapat memberikan kontribusi pada pemahaman yang lebih tentang identitas budaya suku ini dan dapat digunakan sebagai dasar untuk pelestarian dan revitalisasi warisan budaya dalam konteks global yang terus berubah. Dalam metode pola asuh dan pengetahuan kolektif, guna menjaga folklor di Bantimurung.
Unique Pathology in the Locus Coeruleus of Individuals with Down Syndrome
Authors: Saternos Hannah , Hamlett Eric D. , Guzman Samuel , Head Elizabeth , Granholm Ann-Charlotte , Ledreux Aurélie
Published: August 2024

Background:

Down syndrome (DS) is one of the most commonly occurring chromosomal conditions. Most individuals with DS develop Alzheimer’s disease (AD) by 50 years of age. Recent evidence suggests that AD pathology in the locus coeruleus (LC) is an early event in sporadic AD. It is likely that the widespread axonal network of LC neurons contributes to the spread of tau pathology in the AD brain, although this has not been investigated in DS-AD.

Objective:

The main purpose of this study was to profile AD pathology and neuroinflammation in the LC, comparing AD and DS-AD in postmortem human tissues.

Methods:

We utilized immunofluorescence and semi-quantitative analyses of pTau (4 different forms), amyloid-β (Aβ), glial, and neuronal markers in the LC across 36 cases (control, DS-AD, and AD) to compare the different pathological profiles.

Results:

Oligomeric tau was highly elevated in DS-AD cases compared to LOAD or EOAD cases. The distribution of staining for pT231 was elevated in DS-AD and EOAD compared to the LOAD group. The DS-AD group exhibited increased Aβ immunostaining compared to AD cases. The number of tau-bearing neurons was also significantly different between the EOAD and DS-AD cases compared to the LOAD cases.

Conclusions:

While inflammation, pTau, and Aβ are all involved in AD pathology, their contribution to disease progression may differ depending on the diagnosis. Our results suggest that DS-AD and EOAD may be more similar in pathology than LOAD. Our study highlights unique avenues to further our understanding of the mechanisms governing AD neuropathology.
Metabolomic screening and urolithins metabotypes identification in the urinary metabolome of Costa Rican volunteers after blackberry (Rubus adenotrichos)-based drink consumption
Authors: Fallas-Ramirez José-Manuel , Baltodano-Viales Eleaneth , Mora-Román Juan-José , Hernandez Lorena , Pérez Ana M. , Vaillant Fabrice
Published: August 2024

BACKGROUND:

Besides providing nutritional value, functional foods have potential beneficial effects on health. Consumers worldwide seek food products with added value based on physical and mental well-being.

OBJECTIVE:

This study aimed to analyze the urinary metabolome of volunteers who consumed a drink based on Costa Rican blackberries ( Rubus adenotrichos) to identify the presence of urolithins and other possible bioactive compounds related to beneficial effects on health.

METHODS:

Fifteen healthy non-smoking male volunteers aged between 19 and 43 years old who consumed 250 ml of blackberry-based drink for breakfast for eight consecutive days were selected. Urine samples were obtained before and after drink consumption, which were submitted to analysis by Ultra-Performance Liquid Chromatography coupled to a Mass Detector (UPLC/ESI-Q-TOF-MS). Subsequently, a metabolomic analysis of the results was performed to identify the presence or absence of urolithins and other bioactive metabolites related to blackberry juice consumption.

RESULTS:

It was possible to detect high intensity presence of urolithin A ( n = 6) and high intensity presence of both urolithin A and B ( n = 5) in urine samples in several volunteers. However, finding them was impossible in others, or they were at very low intensities ( n = 4). Likewise, it was possible to identify Menth-1-en-4,8 diol glucuronide and 1-O-E-Cinnamoyl-(6-arabinosylglucose) as other compounds related to the consumption of blackberries.

CONCLUSIONS:

The consumption of Costa Rican blackberries allowed us to demonstrate the presence of three metabotypes within the study population: 40% of strong urolithin A (UAP) producers, 33.3% of both urolithin (A and B) producers (UBP), and 26.7% of weak urolithin A producers (0P). Finally, it is recommended to carry out more research in this regard, considering a greater number of volunteers and including people of both sexes.