bluuebunny/crossref_metadata_2025 huggingface dataset:
HOW PREPARED ARE WE FOR THE NEXT PANDEMIC? TAKING A CUE FROM THE CHALLENGES IN THE MANAGEMENT OF SICKLE CELL DISEASE DURING THE LAST COVID 19 PANDEMIC IN NIGERIA
Authors: Omunakwe Hannah E. , Nwogoh Benedict , Nnachi Oluomachi Charity , U Musa Abubakar , HC Okoye , L Uche Chika , Yuguda Saleh , Essien Ofonime , David Ekaette , J Olanrewaju Olusola , Awwalu Sani , A Dachi Rufai , M Opadeyi Oluwaseyi , Korubo Kaladada
Published: August 2023

Background: The Covid-19 pandemic affected healthcare delivery globally.
The impact was more for individuals with chronic diseases requiring
regular visits to the hospital. This study aimed to assess the impact of
the pandemic on care for patients with Sickle cell disease (SCD) in
Nigeria. Methods: This was a cross-sectional survey involving 435 SCD
patients from the six geopolitical zones of Nigeria. Data was collected
through pre-tested and validated, semi-structured questionnaires using
Google forms online and face-to-face interviews at the Clinic. Results:
Teaching hospitals were the most utilised health facility by the
respondents 269 (61.8%). Bone pain was the most frequent crisis 318
(70.7%) with a significant increase in frequency during the pandemic
when compared with the preceding year, p=0.004. Many of the
respondents 227(52.2%) required hospitalization during the pandemic.
Major concerns expressed for accessing care include fear of exposure to
Covid-19-infected patients or health workers who have been exposed to
Covid and conversion of regular health facilities to Covid-19 treatment
centres. During the Pandemic, 102 (23.4%) respondents had easy access
to their doctors and telemedicine was available to 87(20%) but 56
(12.9%) and 97 (22.3%, ) had difficulties in getting blood transfusion
and accessing laboratory tests respectively. Up to 139(32.9%) did not
have difficulties getting pain relief, 169 (38.9%) had their routine
medications while 166 (38.2%) had their income significantly affected
during the pandemic. Conclusion: The findings revealed challenges in
accessing routine medical care, concerns about exposure to COVID-19, and
disruptions in healthcare services. This article discusses the
implications of the survey results and proposes strategies to strengthen
sickle cell care in preparation for future pandemics.
STUDYING EFFECTS OF DUFOUR, SORET, THERMAL RADIATION & CHEMICALLY REACTION IN AN UNSTEADY MAGNETOHYDRODYNAMICS FLOW WITH PERIODIC ACCELERATION THROUGH A FLAT PLATE
Authors: MUDOI⃰ S. , Sarma Dipak
Published: August 2023

An analysis of thermal radiation & chemical reaction effects on a flow
of an incompressible, electrically conducting, viscous fluid through an
infinitely long, flat plate that is accelerating periodically and is
ingrained in porous medium. This flow is studied using unsteady
magnetohydrodynamics. Here, flow is caused by time-related motion of
this vertical plate, also numerous temperature situations along with
velocity as well as concentration situations for different parameter
studies are done.
Two Nearest Means: A New Case Based Reasoning Method
Authors: Alemi Farrokh , Vongala Madhukar Reddy , Durbha Mr. Sri Surya Krishna Rama Taraka Naren , Zargoush Manaf
Published: August 2023

Objective: Case-based reasoning predicts outcomes based on
matching to training cases and without modeling the relationship between
features and outcome. This study compares the accuracy of the two
nearest means (2NM), a case-based reasoning, to regression, a
feature-based reasoning. Data Sources: The accuracy of the two
methods was examined in predicting mortality of 296,051 residents in
Veterans Health Affairs nursing homes. Data was collected from 1/1/2000
to 9/10/2012. Data was randomly divided into training (90%) and
validation (10%) samples. Study Design: Case-control
observational study Data Collection/Extraction Methods: In the
2NM algorithm, first data was transformed so that all features are
monotonely related to the outcome. Second, all means that violate
monotone order were set aside; to be processed as exceptions to the
general algorithm. Third, for predicting a new case, the means in the
training set are divided into “excessive” and “partial” means, based
on how they match a new case. Finally, the outcome for the new case is
predicted as the average of two means: the excessive mean with minimum
outcome and the partial mean with maximum outcome. For regression, we
predicted mortality from age, gender, and 10 disabilities.
Principal Findings: In cases set aside for validation, the 2NM
had a McFadden Pseudo R-squared of 0.51. The linear logistic regression,
trained on the same training sample and predicting to the same
validation cases, had a McFadden Pseudo R-squared of 0.09. The 2NM was
significantly more accurate (alpha <0.001) than linear
logistic regression. Conclusions : 2NM, a Case-Based reasoning
method, captured nonlinear interactions in the data.
Comparing tonic and phasic calcium in the dendrites of vulnerable midbrain neurons
Authors: Chen Rita , Evans Rebekah
Published: August 2023

Several midbrain nuclei degenerate in Parkinson’s Disease. Many of these
nuclei share the common characteristics that are thought to contribute
to their selective vulnerability, including pacemaking activity and high
levels of calcium influx. In addition to the well-characterized
dopaminergic neurons of the substantia nigra pars compacta (SNc), the
cholinergic neurons of the pedunculopontine nucleus (PPN) also
degenerate in PD. It is well established that the low-threshold L-type
calcium current is a main contributor to tonic calcium in SNc
dopaminergic neurons and is hypothesized to contribute to their
selective vulnerability. However, it is not yet clear whether the
vulnerable PPN cholinergic neurons share this property. Therefore, we
used two-photon dendritic calcium imaging and whole-cell
electrophysiology to evaluate the role of L-type calcium channels in the
tonic and phasic activity of PPN neurons and the corresponding dendritic
calcium signal and directly compare these characteristics to SNc
neurons. We found that blocking L-type channels reduces tonic firing
rate and dendritic calcium levels in SNc neurons. By contrast, the
calcium load in PPN neurons during pacemaking did not depend on L-type
channels. However, we find that blocking L-type channels reduces phasic
calcium influx in PPN dendrites. Together, these findings show that
L-type calcium channels play different roles in the activity of SNc and
PPN neurons, and suggest that low-threshold L-type channels are not
responsible for tonic calcium levels in PPN cholinergic neurons and are
therefore not likely to be a source of selective vulnerability in these
cells.
Comparison of the diagnostic efficacy of the Abbott RealTime SARS-CoV-2 assay and the BGI real-time fluorescent RT-PCR kit for the RT-PCR-based detection of Severe Acute Respiratory Syndrome Coronavirus-2
Authors: Stojcevic-Maletic Jelena , Barjaktarovic Iva , Baculov Katarina , Cabarkapa Velibor , Sakac Vladimir , Gojkovic Zoran
Published: August 2023

Introduction/Objective. Based on the WHO Organization guidelines, the current gold standard to diagnose Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is reverse transcription-quantitative real-time polymerase chain reaction (RT-qPCR). The objective of this study was to compare and analyze the detection performance of two different authorized SARS-CoV-2 nucleic acid detection assays: the Abbott RealTime SARS-CoV-2 (ACOV) assay and the BGI Real-Time Fluorescent RT-PCR (BGI) kit. Methods. Our study included 384 randomly selected nasopharyngeal and oropharyngeal swabs previously tested by the ACOV and subsequently tested by the BGI kit for detecting SARS-CoV-2. All patients were adult individuals with symptoms of or suspected Coronavirus disease 2019 (COVID-19). Results. We found that the ACOV assay detected more cases of COVID-19 infection than the BGI assay. The positive percent agreement was 98.3% (95% confidence intervals (95% CI): 95.7?99.3%), while Cohen?s Kappa coefficient was 0.86 (95% CI: 0.80?0.91), indicating a strong level of agreement between these two tests. The negative percent agreement was 85.1% (95% CI: 78.3?90%), while 5.47% of cases were false negative using the BGI test to detect SARS-CoV-2. The sensitivity of the BGI test compared to ACOV was 91.73% (95% CI: 87.64?94.81%), and the specificity of the BGI test was 96.77% (95% CI: 91.95?99.11%). Conclusion. The ACOV showed a bit better diagnostic performance, and due to possible false negative results using the BGI test, we recommend complete testing with the ACOV test.
Les Index de nature urbaine : cadre méthodologique et indicateurs clés
Authors:   IUCN, International Union for Conservation of Nature
Published: August 2023

L’Alliance urbaine de l’UICN, une large coalition d’entités constitutives de l’UICN concernées par les dimensions urbaines de la conservation de la nature, a dévoilé un nouvel produit de connaissance pour mesurer la performance écologique des villes : les Index de nature urbaine de l’UICN (en anglais « Urban Nature Indexes » ou INU). Composé de six thèmes et de cinq « sujets indicateurs » imbriqués dans chaque thème, les INU ont pour but d’aider les décideurs politiques, les parties prenantes et les communautés locales à comprendre leur impact sur la nature, à fixer des objectifs d’amélioration fondés sur la science et à suivre les progrès réalisés à l’aide de mesures scientifiques. En renforçant la transparence et la responsabilité environnementales, et en se concentrant sur l’amélioration plutôt que sur des objectifs fixes, les INU visent à catalyser l’action locale en faveur de la nature dans toutes les villes.
Does XBRL Tagging Indicate Disclosure Quality? The Relationship Between XBRL Standard and Extension Tags and Stock Return Synchronicity
Authors: Lim Jee-Hae , Richardson Vernon J. , Smith Rod
Published: August 2023

We propose new measures of financial disclosure quality based on XBRL standard and extension tag counts. XBRL is designed to allow users to analyze more financial statement detail, thereby increasing reporting transparency. Thus, firms that use more XBRL standard tags should produce more detailed and comparable financial reports. To test this assertion, we examine the association between XBRL tag counts and stock return synchronicity, which measures the market’s reaction to the quality of firms’ disclosures. We find that firms that use more standard taxonomy tags in their 10-K reports have higher stock return synchronicity after the 10-K filing. However, we find that stock return synchronicity decreases as XBRL extension tag counts increase, suggesting that the use of extension tags reduces disclosure quality. Our findings contribute to the growing body of research on XBRL disclosure.

Data Availability: Data are available from the public sources cited in the text.
Investigating the Effect of Service Messages on Noncompliant Taxpayers’ Reactions to Imperfect Audits
Authors: Collum Nina S. , Jurney Susan , Marshall Mary E.
Published: August 2023

We examine the effect of imperfect detection processes in tax examinations. In an experiment using 802 U.S. taxpayers, we find a significant relationship between imperfect audits and post-audit taxpayer compliance in subsequent periods. Although the most obvious solution is to invest the resources necessary to reduce the occurrence of imperfect audits, this solution requires significant budgetary investment. Thus, we test whether the inclusion of a low-cost service message can offset the negative effect of imperfect detection. Further, we find no evidence that the inclusion of a message has any negative effect on the subsequent compliance choices of those who were initially compliant or those who went unaudited. Interestingly, we identify a marginally significant increase in compliance when evaders who were unaudited view the service message. Results contribute to literature on individual tax compliance behavior, particularly related to taxpayers’ awareness of the balance between the service and enforcement efforts.
Randomization to a Provided Higher-Complex Carbohydrate vs. Conventional Diet in Gestational Diabetes Results in Similar Maternal 24-hour Glycemia and Newborn Adiposity
Authors: Hernandez Teri L. , Farabi Sarah S. , Fosdick Bailey K. , Hirsch Nicole , Z. Dunn Emily , Rolloff Kristy , Corbett John P. , Haugen Elizabeth , Marden Tyson , Higgins Janine , Friedman Jacob E. , Barbour Linda A.
Published: August 2023

Objective: Nutrition therapy for gestational diabetes (GDM) has conventionally focused on carbohydrate restriction. In a randomized controlled trial (RCT), we tested the hypothesis that a diet (all meals provided) with liberalized complex carbohydrate (60%) and lower fat (25%)(CHOICE™) could improve maternal insulin resistance and 24-hr glycemia, resulting in reduced newborn adiposity (NB�t; powered outcome) vs. a conventional lower-carbohydrate (40%)/higher fat (45%) diet (LC/CONV).

Research Design and Methods: After diagnosis (~28-30wks), 59 diet-controlled GDM women (mean±SEM; BMI 32±1 kg/m2) were randomized to a provided LC/CONV or CHOICE™ diet (BMI-matched calories) through delivery. At 30-31 and 36-37wks, a 2-hr 75-g OGTT was performed and a continuous glucose monitor (CGM) was worn (72hrs). Cord blood was collected at delivery. NB�t was measured by air displacement plethysmography (13.4±0.4d).

Results: In n=23/group (mean±SEM; LC/CONV [214g/d carbohydrate] vs. CHOICE™ [316g/d]), NB�t (10.1±1 vs. 10.5±1%), birthweight (3303±98 vs 3293±81g), and cord C-peptide were not different. Weight gain, physical activity, and gestational age at delivery were similar. At 36-37wks, CGM fasting (86±3 vs. 90±3), 1-hr (119±3 vs.117±3), 2-hr postprandial (106±3 vs.108±3mg/dL), %time-in-range (TIR 92±1 vs. 91±1%), and 24-hr glucose area-under-the curve (AUC) were similar between diets. The %time >120mg/dL was statistically higher (8%) in CHOICE™ as was the nocturnal glucose AUC; however, nocturnal %TIR (63-100mg/dL) was not different. There were no between-group differences in OGTT glucose and insulin at 36-37wks.

Conclusion: A ~100g/d difference in carbohydrate intake did not result in between-group differences in NB�t, cord C-peptide, maternal 24-hr glycemia, %TIR, or insulin resistance indices in diet-controlled GDM.
Treatment of gonorrhoea with double doses of demethylchlortetracycline.
Authors: Willcox RR.
Published: August 2023

No abstract available
The modified plasma membranes of the transition and horny cells in normal human
Authors: Brody I.
Published: August 2023

No abstract available
Chromium-protein interactions.
Authors: Samitz MH , Katz SA , Scheiner DM , Gross PR
Published: August 2023

No abstract available
The interaction of surfactants with antimicrobial agents.
Authors: Pirilä V , Salo OP , Pirilä L.
Published: August 2023

No abstract available
Alopecia areata. A follow-up investigation of outpatient material.
Authors: Gip L , Lodin A , Molin L.
Published: August 2023

No abstract available
Gonorrhoea of a congenital duct in the raphe penis.
Authors: Dlabalová H , Kraus Z , Dlabal K , Vortel V
Published: August 2023

No abstract available
Allergy to wool fat. The addition of salicylic acid for patch test purposes.
Authors: Thune P.
Published: August 2023

No abstract available
Delayed skin reaction to human dander in atopic dermatitis.
Authors: Uehara M , Ofuji S.
Published: August 2023

No abstract available
The chicken comb and wattle as experimental model for investigative argon laser
Authors: Ritter EJ , Goldman L , Richfield D , Rockwell Jr RJ , Franzen M
Published: August 2023

No abstract available
The effect of hydrocortisone on skin in organ cultures.
Authors: Caron GA.
Published: August 2023

No abstract available
Lichen nitidus: electron microscopic and immunofluorescence studies
Authors: Clausen J. , Jacobsen FK. , Brandrup F.
Published: August 2023

Skin biopsies from a patient suffering from lichen nitidus were studied by electron microscopy and immunofluorescence studies. Complete disintegration of the stratum basale in the central area of the lesion and signs of acantholysis in the border area were found. In the central part of the lesion the dermo-epidermal junction was severely damaged in most places. In the dermal infiltrate, macrophages and lymphocytes were found with a considerable representation of S√©zary cells, not previously reported in lichen nitidus. The ultrastructural changes are identical with those found in lichen planus. No in vivo bound immunoglobulins, fibrinogen, or complement C3 were found.
Propylthio-uracil-induced cutaneous vasculitis
Authors: Gammeltoft M. , Kristensen JK.
Published: August 2023

Three cases of cutaneous vasculitis, leukocytopenia and arthralgia, presumably caused by the antithyroid drug Propylthio-uracil, are presented. Acute vasculitis of the superficial and deep dermal blood vessels accompanied by vascular thrombus formation were found in biopsy specimens. Direct immunofluorescence studies demonstrated deposits of C3 or IgM and C3 in the walls of vessels in affected and unaffected skin, suggesting immune complex deposition. The skin lesions and leukocytopenia rapidly disappeared on discontinuation of the drug, while the arthralgia continued for weeks or months.
The Klippel Trenaunay Weber Syndrome presenting with cutaneous bleeding
Authors: Adams SJ. , Cunliffe WJ.
Published: August 2023

A patient with the Klippel Trenaunay Weber syndrome presented with prolonged bleeding from the finger tips during strenuous exercise. Tissue fibrinolysis studies showed increased fibrinolytic activity suggesting that the blood vessels in the affected limb may be functionally as well as anatomically abnormal.
Palmo-plantar keratoderma associated with carcinoma of the bronchus
Authors: Kerdel FA. , MacDonald DM.
Published: August 2023

No abstract available.
Aspirin iin the management of necrobiosis lipoidica
Authors: Karkavitsas K. , Miller JA. , Dowd PM. , Kirby JD.
Published: August 2023

No abstract available.
Polymorphous light eruption: a common reaction uncommonly recognized
Authors: Morison WL. , Stern RS.
Published: August 2023

Polymorphous light eruption (PMLE) is usually considered to be an uncommon complaint, although the prevalence in the general population has not been studied. In a survey of 271 apparently healthy subjects, 10% gave a history consistent with a diagnosis of PMLE. The clinical characteristics in the survey cases of PMLE were similar in most respects to those of patients presenting to a clinic with this disorder. However, there was one notable exception, in that there was a striking difference between the clinic and survey cases in the amount of sunlight required to trigger the eruption. Clinic patients required a mean exposure of 30 min as compared with over 3 h in the survey cases. These findings suggest that PMLE is a common disorder but that many individuals have a high threshold of response to sunlight exposure.
Clinical evaluation and pathomechanism of urticaria-like skin eruption in systemic lupus erythematosus
Authors: Horváth A. , Krámer M. , Ablonczy E.
Published: August 2023

Clinical observations of 10 SLE patients having urticaria-like skin symptoms showed that the clinical process of urticaria found in patients suffering from SLE differs from the classic one. On the basis of histological and immunohistological studies in 5 cases, a characteristic histological manifestation of leukocytoclastic vasculitis of small veins in the upper third of the cutis was found. The various urticaria-like skin symptoms in SLE are caused by immunocomplexes of various components. The continuous presence of urticaria is caused by C-activating formation of anaphylatoxin. The appearance of urticaria in SLE patients is an unfavourable precursor which has been confirmed by statistical analysis.
Palmoplantar pustulosis: a neurocutaneous disease?
Authors: Hamann K.
Published: August 2023

No abstract available.
Venereal disease in patients with scabies: a five-year survey
Authors: Munkvad JM. , Nielsen AO. , Secher L.
Published: August 2023

No abstract available.
Staphylococcal scalded skin syndrome in an adult with fatal disseminated staphylococcal sepsis
Authors: Diem E. , Konrad K. , Graninger W.
Published: August 2023

No abstract available.
HLA antigens in Yugoslav patients with palmoplantar keratoderma, type Unna-Thost: a family study
Authors: Kansky A. , Durinović-Belló I. , De Jongh BM.  , Volkers WS. , Arzensek J. , Kerhin-Brkljacic V. , Kastelan A.
Published: August 2023

No abstract available.
The water-binding capacity of stratum corneum in dry non-eczematous skin of atopic eczema
Authors: Werner Y. , Lindberg M. , Forslind B.
Published: August 2023

No abstract available.
Deposits of complement and immunoglobulins in vessel walls in pyoderma gangrenosum
Authors: Ullman S. , Halberg P. , Howitz J.
Published: August 2023

Previous immunofluorescence studies on pyoderma gangrenosum (PG) proved negative. Biopsies from the ulcer edge of 8 patients with PG were examined by immunofluorescence microscopy. Deposits of complement C3 were seen in the vessel walls of all samples, IgM in three and IgA in one. Granular deposits of C3 were seen at the dermal--epidermal junction in 2 patients. Biopsies from clinically normal skin of 6 of the patients were negative. It is suggested that deposition of immune complexes in the dermal vessel walls may play a role in the pathogenesis of PG.
Pyoderma gangrenosum in infancy
Authors: Dick DC. , Mackie RM. , Patrick WJ. , Goel KM.
Published: August 2023

No abstract available.
The effect of etretinate on fibronectin in psoriatic skin
Authors: Lauharanta J. , Salo O. , Kanerva L. , Lassus A.
Published: August 2023

The distribution of fibronectin in psoriatic skin was studied in 6 patients during treatment with oral etretinate using indirect immunofluorescence technique. In untreated lesions fibronectin was clearly visualized in the dermo-epidermal junction (DEJ) and in the walls of papillary capillaries, and showed a reticular or fibrillar pattern in the dermis. In the horny layer there was some fluorescence which we regarded largely as unspecific. In all patients a transient accentuation of fibronectin accumulation in DEJ was seen after 3-7 days of treatment. Except for some decrease in the amount and intensity of capillary fluorescence, no other notable changes occurred in the fibronectin distribution during 4 weeks of treatment.
Onychotillomania treated with pimozide (Orap)
Authors: Hamann K.
Published: August 2023

A case of onychotillomania in a 70-year-old woman is presented. The disease had persisted for 51/2 years. All her fingernails were plucked away. The patient had a fixed hypochondrial delusion of nail disease. After treatment with pimozide (Orap) for 7 months the nails were normal.
Psoriasis treatment and a day-care centre: clinical aspects and an attempt at a cost-benefit analysis
Authors: Larkö O. , Swanbeck G.
Published: August 2023

The practical results of day-care centre treatment of psoriasis have been studied. Patients referred to the centre are generally those where the skin disease covers substantial body areas. The main treatment has been UVB. UVB plus dithranol or PUVA has been used on patients who have failed to respond to UVB alone. With UVB therapy alone, 263/328 patients healed with a median to healing time of 8 weeks, and 9 weeks to relapse. 34/60 patients with a previously poor response to UVB healed on UVB plus dithranol. Median time to healing was 8 weeks and time to relapse, 12 weeks, 24 patients were treated with PUVA, as they had had a poor earlier response to UVB. All healed with a median time to healing of 12 weeks and 25 weeks to relapse. 3.3% of the patients fit for work have at some time during the treatment been off work due to their psoriasis. The cost for this type of treatment is about one-fifteenth of the cost of treatment on a hospital ward.
Low molecular weight dextran in systemic sclerosis and Raynaud´s phenomenon
Authors: Dodman B. , Rowell NR.
Published: August 2023

No abstract available.
Puva photohyposensitization in polymorphous light eruptions: evaluation of systemic immunological factors
Authors: Karvonen J. , Viander M. , Ilonen J. , Jansén CT.
Published: August 2023

Systemic immunological parameters were monitored in 26 polymorphous light eruption (PMLE) patients prior to, during and after photochemotherapy by either an oral or topical (bath) regimen. Pre-therapy investigations showed a normal immune status as regards the numbers of peripheral T-cells as well as the response of peripheral blood lymphocytes to PHA, ConA and PPD. Measurement of the immunological parameters after four PUVA exposures revealed a statistically significant increase in the lymphocyte PHA responses. After the completion of a PUVA course of some 20 irradiations, normalized PHA responses were found. The total lymphocyte count increased slightly during the treatment but the relative numbers of T- and B-cells changed very little. The immunological changes observed were of only moderate strength and it remains doubtful whether they play any major role in the hyposensitizing effect of PUVA irradiations in PMLE.
Diurnal fluctuations of cell kinetic parameters in the epidermis and the sebaceous gland of the hamster ear
Authors: Wirth H. , Spannagel M. , Gloor M.
Published: August 2023

By using the colcemid method, the presence of a diurnal variation for the mitosis index was confirmed, showing a definite minimum during the night in the sebaceous gland of the Syrian hamster ear. Furthermore, the number of all labelled cells and the quotient "single-labelled 14C-cells + double-labelled cells/single-labelled 3H-cells" determined with double-labelling autoradiography ([3H] and [14C]thymidine) seem to be subject to rhythmic fluctuations, although statistical support for this observation is lacking. The parallelism of the rhythmic variations in the epidermis and in the sebaceous glands is striking.
Treatment of Kaposi´s varicelliform eruption wit adenine arabinoside (Vira-A) and transfer factor
Authors: Bjerring P. , Thestrup-Pedersen K. , Zachariae H.
Published: August 2023

Kaposi´s varicelliform eruptions, or Eczema herpeticum, are the result of a herpes virus infection. This paper reports on a patient who was treated with parenteral infusion of a new anti-viral drug, adenine arabinoside (Vira-A), and transfer factor in an attempt to halt the spread and alleviate the severity of the disease. It is our opinion that adenine arabinoside can have a beneficial effect on the course of the disease.
Skin surface and open comedone pH in acne patients
Authors: Holland DB. , Cunliffe WJ.
Published: August 2023

To assess the variability of surface and comedone pH in one and the same individual and between individuals, pH measurements were made on extracted single comedone material and on the adjacent skin surface, at face and back sites on 56 acne patients. The pH values were normally distributed. The mean values were: comedone pH 5.52 and surface pH, 5.26. The pH ranges were similar: comedones 4.01 to 6.85 and surface, 4.10 to 6.81. There was no correlation between comedone pH and adjacent skin surface pH. On each person and at one site there was variability of surface pH and comedone pH. Variability of pH from person to person was greater than within an individual at the same site.
Prenatal exclusion of Herlitz syndrome by electron microscopy of fetal skin biopsies obtained at fetoscopy
Authors: Löfberg L. , Anton-Lamprecht I. , Micha√´lsson G. , Gustavii B.
Published: August 2023

Two women had each borne a child who had died of Herlitz syndrome, i.e., epidermolysis bullosa atrophicans generalisata gravis. In subsequent pregnancies, the women requested prenatal diagnosis. Samples of skin from the two fetuses were obtained at fetoscopy in the 19th week of gestation. In both cases the disorder could be ruled out prenatally on the basis of ultrastructural demonstration of the regular presence of normal hemidesmosomes with well-developed sub-basal dense plates at the dermo-epidermal junction. The infants were subsequently born and had normal skin, the sites of fetal skin biopsies showing no scarring.
The T-lymphocyte and cutaneous Churg-Strauss granuloma
Authors: Winkelmann RK. , Buechner SA. , Powell FC. , Banks PM.
Published: August 2023

Studies of biopsy specimens from 4 patients with Churg-Strauss granulomas of the skin were performed with monoclonal antibodies to T-lymphocyte subset antigens. The finding of a predominance of a LEU3 antibody-reactive helper T-cell population in the perivascular areas and in the palisading and central granuloma areas was noteworthy. Pronounced reduction of suppressor T-cells in the lesions was observed in 2 patients; the lesions were associated with vasculitis and rheumatoid arthritis in one patient and with vasculitis and lupus erythematosus in the other. The Churg-Strauss granuloma demonstrated features of a cutaneous helper T-cell granuloma.
Irritation and staining by dithranol (anthralin) and related compounds. III. Cumulative irritancy and staining during repeated chamber testing
Authors: Brandt H. , Mustakallio KK.
Published: August 2023

Irritation and staining, the side effects of dithranol and related compounds have previously been studied after a single chamber-exposure. To mimic the therapeutic situation, the chamber application was repeated for 3 weeks on the uninvolved back skin of 17 psoriasis patients. In equimolar concentrations corresponding to 0.05% dithranol, dithranol caused markedly more erythema and staining than 10-propionyl dithranol and 10-butyryl dithranol, whereas 10-butyryl dithranol irritated and stained less than 10-propionyl dithranol. To reach the irritation and staining level of dithranol, a 4-fold higher concentration of 10-butyryl dithranol was required. During the first week the irritation culminated, declining later despite repeated applications, possibly because of exhaustion of anthrone-induced inflammatory mediators.
Solar Simulators: modifications for testing with visible light
Authors: Wulf HC. , Brodthagen H.
Published: August 2023

The Berger Solar Simulator is designed to test light-sensitive patients for their sensitivity to ultraviolet light. The present modification was performed to make testing with UV and visible light possible. The modification consists in replacing the dicroic mirror with a beam splitter (BSP 580) and the filters with a WG 340 allowing 340-565 nm to pass. Subdivision of that spectrum is performed by inserting a Wratten 12 (500-565 nm) or a Wratten 2B (400-565 nm). Infrared is excluded by a KG3 filter.
Dermatitis herpetiformis: relation between circulating antibodies against reticulin and gluten, small-intestinal mucosal status and absorptive capacity
Authors: Ljunghall K. , Lööf L. , Grimelius L. , Forsum U. , Jonsson J. , Scheynius A. , Schilling W.
Published: August 2023

The status of the jejunal mucosa and of the intestinal absorptive capacity were investigated and related to the occurrence of antibodies against reticulin and gluten in 55 patients with dermatitis herpetiformis (DH), 28 on a normal, 11 on a gluten-reduced and 16 on a gluten-free diet. The mucosal status was characterized on the basis of histopathological findings and the numbers of intra-epithelial lymphocytes. Absorption was evaluated by 5-h urine and 1-h serum D-xylose tests. There was a positive correlation between the degree of pathological mucosal changes, malabsorption and the occurrence of circulating antibodies against reticulin and gluten. The serum xylose test was more sensitive than the urine xylose test for screening of the relatively mild enteropathy of DH and identified 88% of the patients with an abnormal mucosal status. The serological test (antibodies to reticulin and gluten) identified 80% of such patients. Among patients on a gluten-free diet there was some discrepancy between the serum xylose and the serological test, in that 5 of the 16 patients on this diet had an abnormal serum xylose test result, but no antibodies. In DH patients on a normal diet, the presence of antibodies to reticulin and gluten provided the same information about the presence of mucosal lesions as the serum xylose test. In the whole material a combination of the serum xylose test and the serological test identified 24 of 25 patients with an abnormal mucosal status.
Cutaneous sarcoidosis: an immunofluorescence study
Authors: Ullman S. , Halberg P. , Stahl D. , Veien NK.
Published: August 2023

Biopsy specimens from granulomatous skin lesions of 14 patients with active sarcoidosis were examined by immunofluorescence microscopy. In seven lesions, deposits of IgM, IgA or complement C3 were demonstrated in the dermal vessel walls and/or at the dermal-epidermal junction. Similar deposits were found in three of twelve biopsy specimens from clinically normal skin from a buttock of the same patients. The results support the hypothesis that deposition of circulating immune complexes in the vessel walls may be of importance for the development of granulomatous lesions in sarcoidosis.
Proliferative responses of fibroblasts from psoriatic and normal skin to clobetasol propionate
Authors: Priestley GC. , Adams LW. , Oakley CA. , Prescott RJ.
Published: August 2023

The proliferation of fibroblasts cultured from psoriatic and normal skin was compared following addition of clobetasol propionate to the culture medium. Proliferation was stimulated at 0.1 microgram/ml and progressively inhibited at 1-10 micrograms/ml. A differential sensitivity to the drug was demonstrated: the fibroblasts from involved psoriatic skin were more stimulated than normal fibroblasts at 0.1 microgram/ml and then more inhibited at 10 micrograms/ml. The fibroblasts from uninvolved psoriatic skin displayed intermediate responses. There was some cytotoxicity in cultures of the psoriatic cells at 10 micrograms/ml. The results demonstrate a further abnormality of fibroblasts from psoriatic skin.
Formaldehyde-induced fluorescence method for touch preparations from amelanotic melanoma tissues: a simple and rapid method for the demonstration of melanogenic activities of amelanotic melanoma cells
Authors: Morishima T. , Nagashima N.
Published: August 2023

Touch preparations from four amelanotic melanoma tissue samples were studied with the formaldehyde-induced fluorescence method. Fluorescent amelanotic melanoma cells could easily be detected under a fluorescence microscope. The fluorescence microscopic pictures obtained by the touch-fluorescence method were equally evaluated with those obtained by the classical fluorescence method. The method made it possible to demonstrate the melanogenic activity of amelanotic melanoma cells within 30 min. The routine application of this method to the diagnosis of amelanotic melanoma is suggested.
Are endothelial cells stimulated by autoantibodies in scleroderma?
Authors: Nunzi E. , Rebora A.
Published: August 2023

No abstract available.
Diphencyprone in the treatment of alopecia areata
Authors: Happle R. , Hausen BM. , Wiesner-Menzel L.
Published: August 2023

27 patients suffering from either extensive alopecia areata (n = 5) or alopecia totalis (n = 22) were treated topically with diphencyprone, a new potent contact allergen. The duration of treatment ranged from 4 to 17 months. Unilateral induction of hair growth after unilateral treatment was observed in 23 patients. A continuous response after continuous treatment has been observed so far in 18 of these patients. Thus, diphencyprone was found to be as effective as DNCB or squaric acid dibutylester in the treatment of alopecia areata. Unlike DNCB, diphencyprone is not mutagenic in the Ames test. Compared with squaric acid dibutylester, diphencyprone is more stable and thus more suitable for storage when dissolved in acetone. Further investigative evaluation of diphencyprone may show whether this drug is suitable for a more general use in the treatment of severe forms of alopecia areata.
Ultrastructural localization of in vitro binding sites of circulating anti-basement membrane zone antibodies in bullous pemphigoid
Authors: Yamasaki Y. , Nishikawa T.
Published: August 2023

Ultrastructural localization of the in vitro binding sites of circulating anti-basement membrane zone antibodies was investigated using two immunoperoxidase methods: the ordinary IgG indirect immunoperoxidase method and the complement immunoperoxidase method. The results indicate that the binding sites of the circulating autoantibodies were diverse. It is postulated that those antibodies demonstrable by the ordinary IgG indirect method and those antibodies possessing capacity to fix complement should bind to different sites of the basement membrane zone. Conventional electron microscopic observation of one lesional skin from bullous pemphigoid confirmed this possibility. (Received December 23, 1982.)
PUVA treatment of alopecia totalis
Authors: Larkö O. , Swanbeck G.
Published: August 2023

40 patients with alopecia totalis have been treated with PUVA. 26 did not respond, 6 experienced a partial hair regrowth, while 8 got a complete regrowth. However, relapses were frequent, occurring at an early stage.
Pyoderma gangrenosum treated with clofazimine: clinical evaluation of 7 cases
Authors: Rasmussen I.
Published: August 2023

Seven patients with pyoderma gangrenosum have been treated with clofazimine. In contrast to the beneficial effect described in other articles only one healed. (Received March 27, 1983.)
Cellulitis caused by Vibrio alginolyticus
Authors: Aelvoet G. , Kets R. , Pattyn SR.
Published: August 2023

A case of cellulitis, resulting in a recurrence of a leg ulcer is presented due to the unique association of its bacterial flora, consisting exclusively of V. alginolyticus and of its clinically rapid expansion after seabathing.
HLA -A, -B, -C and -DR antigens in individuals with sensitivity to cobalt
Authors: Fischer T , Rystedt I , Säfwenberg J , Egle I.
Published: August 2023

In a skin investigation of 853 individuals working with hard metal manufacturing 39 cases of cobalt allergy were found. Thirty-five of the individuals with cobalt sensitivity and 102 matched controls were HLA-A, -B, -C and -DR typed. No significantly deviating HLA antigen frequencies were observed when the two groups were compared. Thus, there are no signs that a certain HLA antigen would dispose to cobalt allergy. In the cobalt sensitive group the B7 positive individuals showed particularly often simultaneous reactions to other contact allergens (p = less than 0.025). The B12 positive individuals had low reactivity (p = less than 0.0001) while the A28 positive showed high reactivity (p = less than 0.015).
Flare-up of allergic contact dermatitis in the mouse after topical distant provocation
Authors: Möller H.
Published: August 2023

Flare-up of contact dermatitis after exposure to the antigen on another skin area was studied in the mouse. Animals were sensitized and challenged with picryl chloride. After healing, the ear dermatitis flared up following provocation on abdominal skin. Likewise, nickel-sensitized mice flared in one ear when exposed to the antigen on the other ear. This model could be of use in pathogenetic studies on secondary eruptions which occur so frequently in contact dermatitis.
Herpes simplex as a possibly occupational disease in dentists of the County of Aarhus, Denmark
Authors: Rames S , Folkmar T , Roed-Petersen B.
Published: August 2023

Among the 765 dentists of the County of Aarhus , Denmark, a total of 65% answered a questionnaire on possible herpes panaritium experience. Among the answers 3.8% were positive. Among these, 10 had circulating antibodies against herpes simplex virus. During the study a case of recurrence of a panaritium , which appeared to be a herpes simplex infection, occurred.
Twenty-nail dystrophy: report of a case and review of the literature
Authors: Donofrio P , Ayala F.
Published: August 2023

A case of twenty-nail dystrophy in an 7-year-old girl is presented. The histopathological findings were incompatible with lichen planus. The differential diagnosis is briefly discussed, and the literature reviewed.
Psoriasis in first-degree relatives of psoriatic twins
Authors: Brandrup F.
Published: August 2023

Analysis of the presence of psoriasis in all first-degree relatives of psoriatic twin probands, 38 monozygotic (MZ) and 24 dizygotic (DZ), has been performed in order to clarify if genetic heterogeneity might be present (the twin-family method). The probands were derived from a population based sample of like-sexed twin pairs. An almost identical frequency of psoriasis in parents, siblings and children, with no sex difference, was found. By comparisons of empirical risk figures for psoriasis in first-degree relatives of concordant as compared with discordant MZ probands and HLA-B 13 and/or HLA-B 17 positive MZ probands compared with MZ probands lacking these antigens, no clue to the presence of genetic heterogeneity was found. An almost identical risk in co-twins and ordinary siblings of DZ-probands was found. The data were incompatible with autosomal recessive or X-linked inheritance, but not incompatible with autosomal dominant inheritance with reduced penetrance or with multifactorial inheritance.
Leg and foot ulcers. An epidemiological survey
Authors: Andersson E , Hansson C , Swanbeck G.
Published: August 2023

Medical records for leg and foot ulcer patients have been investigated, 1377 patients were found. The median age for women was 76 years and for men 70 years. Totally there was a majority of women, 61%. The age specific frequencies for leg and foot ulcer patients did however not differ between men and women. Thirty percent of all patients had ulcers on the feet only. The ratio between men and women for feet ulcers was 1:1. Men got their feet ulcers 5-10 years earlier than women. Seventeen percent of all patients had ulcers on the medial side of the calf only. Seventy percent of these patients were women. A rough estimate of the prevalence of leg and foot ulcer patients was made to between 0.2-0.4% of the whole population. The involvement of different medical disciplines in the care of leg and foot ulcer patients in Gothenburg is reported.
Clinical and scanning electron microscopic findings in a solitary case of Trichorhinophalangeal syndrome type I
Authors: Prens EP , Peereboom-Wynia JD , De Bruyn WC , Van Joost T , Stolz E.
Published: August 2023

A solitary case of Trichorhinophalangeal syndrome type I is described. Scanning electron microscopic examination revealed alterations of the cuticular pattern and hair shaft structure. These alterations have not been previously described and differ from those seen in other syndromes belonging to the group of the ectodermal dysplasias e.g. the Trichoonytic Hidrotic ectodermal dysplasia, autosomal recessive Anhidrotic ectodermal dysplasia and X-linked Anhidrotic ectodermal dysplasia.
Prochlorperazine--an unusual cause of lip ulceration
Authors: Reilly GD , Wood ML.
Published: August 2023

A case is reported of a fixed drug eruption due to Prochlorperazine maleate which caused ulceration of the lower lip confirmed by a positive provocation test.
Skin irritancy from propylene glycol
Authors: Wahlberg JE , Nilsson G.
Published: August 2023

Two sensitive methods for the assessment of skin irritancy reactions to propylene glycol (PG) have been used: laser Doppler flowmetry in man for erythema and skin fold thickness measurements in man, guinea pigs and rabbits for edema. Single (open and occlusive) and repeated (open) exposures were used. Trafuril was used as positive control for the flowmetric studies. In man an increased blood flow was recorded only when PG was applied under occlusion. A statistically significant increase in skin fold thickness was observed from day 7 in the guinea pig, but not in man (daily exposures for 36 days). It is concluded that occlusion seems to be a crucial factor and that skin fold thickness measurements in guinea pigs and rabbits is a useful, complementary method for the detection and prediction of marginal irritants.
Meclosorb, a new topical antibiotic agent in the treatment of acne vulgaris: a double-blind clinical study
Authors: Hjorth N , Schmidt H , Thomsen K , Dela K.
Published: August 2023

The clinical effect on acne vulgaris of topical treatment with meclocycline sulfosalicylate and systemic treatment with peroral tetracycline (500 mg daily) was compared in a double-blind study of 60 patients treated for 8 weeks. The reducing effect of Meclosorb cream and tetracycline tablets on the number of closed comedones, pustules, papules and cysts was marked and not significantly different. The effect of Meclosorb on open comedones was weak and of slow onset. No side effects were registered. Topical treatment with Meclosorb is an effective and safe alternative to systemic tetracycline treatment of acne vulgaris.
Brittle hair in osteogenesis imperfecta: transmission and scanning electron microscopy and mycologic assay
Authors: Forslind B , Kaaman T.
Published: August 2023

The brittle hair fibres from a case of osteogenesis imperfecta were studied by scanning and transmission electron microscopy. Normal hair fibres are extremely difficult to infect with T. mentagrophytes. As a tentative assay for biochemical defects of hair fibres, experimental dermatophytic infection of the hair with T. mentagrophytes was performed. The massive growth induced suggested that the experimental fungal infection may indeed indicate a biochemical defect in the hairs from our case of osteogenesis imperfecta.
Phenotypic characterization of skin-infiltrating cells in pagetoid reticulosis by monoclonal antibodies
Authors: Gonzalez M , Martin-Pascual M , San Miguel J , Caballero MD , López Borrasca A.
Published: August 2023

The immunological characterization of the infiltrating cells in a patient with a disseminated form of Pagetoid reticulosis (PR) was carried out-in histological section and cell suspensions--by means of a panel of monoclonal antibodies and classical markers (E-rosette and surface immunoglobulins (SIg]. Most of the infiltrating cells were seen to be mature T-lymphocytes with a suppressor/cytotoxic phenotype (T11+, T3+, T8+, T4-). The results suggest that this variant of PR represents a special histological type of cutaneous T cell lymphoma.
Treatment of alopecia areata with dinitrochlorobenzene
Authors: Temmerman L , De Weert J , De Keyser L , Kint A.
Published: August 2023

Thirty patients with severe alopecia areata (A. A.) were treated with weekly applications of dinitrochlorobenzene (DNCB) in acetone solution. In only four patients regrowth of hair was complete and dense; sixteen patients experienced temporary results and in ten the treatment was a failure.
Immunohistochemical staining characteristics of epidermal appendages (hair follicles and eccrine sweat glands) to anti-epidermal keratin antisera
Authors: Hosokawa M , Ohkohchi K , Tagami H.
Published: August 2023

The cellular characteristics of the epidermal appendages and their differentiations in relation to those of the epidermis have been chiefly studied from the morphological points in the past. We investigated them from the immunohistochemical characteristics of the constituent keratin protein to the antiserum against total keratin isolated from human plantar stratum corneum (TKA) which stains the whole epidermis, and to the antiserum against 64K keratin separated from total keratin (64KA) which stains the whole epidermis except the basal layer. In the hair follicles, medulla and cortex of the hair shaft and inner root sheath were positively stained with both types of the antisera only at the keratogenous zone. The staining pattern of the outer root sheath with 64KA were variable at different levels of the hair follicle. The secretory portion of the eccrine glands showed a heterogeneous staining pattern as compared with the ductal portions which were stained homogeneously by both antisera. In eccrine poroma, all of the tumor cells were stained positively with TKA, while negatively or positively stained cells were intermingled with 64KA, suggesting that only some tumor cells showed mature keratinization.