bluuebunny/crossref_metadata_2025 huggingface dataset:
ABI Sanger Sequencing of Avian Clock genes to elucidate markers for Migration Phenology v1
Authors: Le Clercq Louis-Stéphane
Published: November 2023

This protocol follows up on "PCR Amplification of Clock genes withEmeraldAmp® GT PCR Master Mix in Avian species" and is intended to provide the next steps used in the sanger sequencing of the produced amplicons. This protocol uses ABI BigDye reagents (but suitable alternatives exist). The same primers used to produce the PCR products, of the respective clock genes, are used individually in a forward and reverse sequencing reaction. Cycling conditions mimic those used for PCR. Sequencing reactions are purified and subsequently resolved on an ABI Genetic Analyzer. The sequence read data was used in a BLAST search and confirmed to be the genes and regions of interest for all tested species.
PCR Amplification of Clock and Adcyap1 genes withEmeraldAmp® GT PCR Master Mix in Avian species for polymorphism elucidation v1
Authors: Le Clercq Louis-Stéphane
Published: November 2023

This PCR protocol is used to amplify Clock and Adcyap1 gene regions in avian species which have previously shown polymorphisms, such as poly-Q runs, that correlated to migration phenology. It was tested and optimized in Woodlands kingfisher (Halcyon senegalensis) and Diederik cuckoos (Chrysococcyx caprius). The primers were designed based on those previously used by Johnson et al. (2007) and Steinmeyer et al. (2009) by comparing the relevant gene sequences for chickens (Galus galus) with several other available avian species to select primers that would account for the most common variations in primer regions, enabling more universal amplification. Individual clock gene sequences were retrieved from Genbank and aligned in BioEdit 7.2. Primers were then selected based on the annotated regions. The assay was designed using 25 μL (half) reactions of EmeraldAmp® GT PCR Master Mix, which is premixed with loading buffer for easy gel loading following PCR and does not require a long initial denaturation step (thereby shortening the run time). Gel electrophoresis was able to confirm successful amplification of a product ±280 bp long in both species. The same primers were subsequently used for sanger sequencing. A BLAST search of the resulting sequences confirmed the identity of the amplified regions.
GGAssmbler Library Construction v2
Authors: Yakir Hoch Shlomo
Published: November 2023

This protocol describes methods for GGAssembler.
Beam test v1
Authors: Lorente Picón Marina
Published: November 2023

Beam test for mice
Hukuk Savaşımının Kavramsal Çerçevesi ve Uygulamaları Üzerine Bir İnceleme
Authors: Arslan Beyzanur
Published: November 2023

Güncel çatışmalarda hukukun bir meşruiyet kaynağı olarak görülmesiyle birlikte savaş ve hukuk hiç olmadığı kadar yakın bir ilişkiye girmiştir. Uluslararası hukukun bir araç olarak politik ve askerî hedeflere ulaşma amacıyla kullanılması, yani hukuk savaşımı kavramı, bu yüzyılın başından beri yaygınlaşmıştır. Uluslararası aktörlerin giderek artan bir şekilde hukuk savaşımı faaliyetlerine girişmesi bu eğilimin süreceğini göstermekte, dolayısıyla kavrama ışık tutmayı gerekli kılmaktadır. Bu amaçla makalede hukuk savaşımının ne olduğunun, niçin ortaya çıktığının ve nasıl yürütüldüğünün sorgulanmasıyla kavramsal çerçevesi analiz edilecek ve bir tür yeni nesil savaş olup olmadığı tartışılacaktır. İlk kısımda kavrama ilişkin tanımlar, kullanıldığı boyutlar ve ayırt edici özellikler üzerinde durulacaktır. Kavramı ortaya çıkaran gelişmeler incelenecek; bunun ardından devlet, devlet dışı aktör ve sivil toplum kuruluşlarının uygulamaları, hukuk savaşımının tipolojisi ve çekişme yöntemi bakımından açıklanacaktır. İkinci kısımda ise bu uygulamaların bir savaş biçimi oluşturup oluşturmadığı, uluslararası hukukun doğası ve meşruiyet arayışı bağlamında değerlendirilecektir. Makale, hukuk savaşımının bir asimetri oluşturulmasına veya asimetriye mukabele etmeye imkân vermekle birlikte, yeni nesil bir savaş olmadığını, zira kavramın temelinde yatan hukuki çekişme olgusunun uluslararası hukukun eskiden beri süregelen, kendine has özelliklerinden doğduğunu ileri sürmektedir.
On the Scientific Validity of the Program of Work of a Psychologist with Teaching Staff and Teachers on the Prevention of Suicidal Risks in the Educational Organization “I Choose Life!”
Authors: Seryakina A.V. , Ramzaeva V.Yu.
Published: November 2023

The authors of the article pose the question: are modern teachers ready to participate in solving the problem of adolescent suicide, and come to the conclusion that, despite the large number of different diagnostic tools and literature, they are not ready to use them in practice. To solve this and other issues, the authors propose to carry out a system of measures related to increasing the competence of the teaching staff, developing their practical skills, motivational and psychological readiness to carry out work on the prevention of suicidal risks. This system formed the basis of the program of work of the educational psychologist with teaching staff and teachers “I choose life!” The implementation of the program contributes to the formation of a safe educational environment, the prevention of destructive behavior, suicidal and other risks. It was tested on the basis of the state autonomous institution of additional professional education “Saratov Regional Institute for Educational Development” as part of the implementation of an additional professional development program “Strategies for the work of an educational organization with the problem of suicidal behavior of minors” for class teachers, educational psychologists and heads of educational organizations. The program “I choose life!” passed an examination to verify the evidence base within the section “Evidence-Based Approach in Psychology and Education” of the Scientific Expert Council of the Federal State Budgetary Educational Institution of Higher Education MSUPE with the assignment of a certificate of conformity (registration number “7/17-pr” dated July 25, 2023). Based on the results of the examination, it was found to comply with the standards of programs and technologies with proven effectiveness for the educational and social spheres, taking into account additional recommendations, and was recommended for inclusion in the register of exemplary correctional and developmental, correctional, rehabilitation and preventive programs for the activities of a teacher-psychologist (psychologist in the field of education ) and replication in educational and social institutions.
COVID-19 Pandemic, Rationality of Choice and Moral Dilemmas
Authors: Pervushin N.S.
Published: November 2023

In his article, the author describes the COVID-19 pandemic as a unique situation on a global scale, which has brought a number of eternal questions from the philosophical-speculative plane to the most practical. In fact, it made it a matter of “life and death” for every person. First of all, this is a question of moral choice in a situation with a high degree of uncertainty — between personal freedom and personal restrictions for the benefit of other people. The article also analyzes strategies to fight the COVID-19 pandemic in different countries and the consequences of their implementation in relation to moral dilemmas. Based on an analysis of international experience, the psychological features of the introduction of restrictions and external state and public control (as examples of the implementation of a universal rational approach) are discussed. The author takes into account socio-economic statistics accumulated over two years (excess mortality, gross domestic product, etc.), which show that in the context of a pandemic, a rational construct, which provides for the renunciation of some personal freedoms by citizens for the sake of the public good, is preferable to an empirical one, in which people they are given the right to make their own moral choice - to renounce freedoms or not. At the same time, the author comes to the conclusion that, along with the advantages, rationalization can have disadvantages. Namely: long-term risks associated with society’s gradual abandonment of personal freedoms and democracy and a return to an authoritarian system.
Self-management Web Application for Persons with Schizophrenia
Authors: Domingues José , Gomes Paulo Veloso , Almeida Raquel Simoes de , Fonseca Nuno , Martins Constantino , Santos Joaquim , Marques António , Pereira-Loureiro Javier
Published: November 2023

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Ultra Wideband for Shipyard 5.0 Indoor Gantry Crane High-Precision Positioning
Authors: Niebla Montero Ángel , Fraga-Lamas Paula , Varela-Barbeito José , Fernández-Caramés Tiago M.
Published: November 2023

The shipyard of the future, called Shipyard 5.0, is a highly technological environment where real-time monitoring of products, by-products and transport vehicles is crucial. Among the technologies able to locate such elements indoors, Ultra Wideband (UWB) is a good option for providing accurate positioning. However, the use of UWB in shipyards faces challenges due to interference from metallic objects, which impacts its accuracy. To validate the use of UWB in a shipyard, this paper presents tests that were carried out in workshops that Navantia owns in Ferrol’s estuary, where UWB tags were placed on a gantry crane hook. The presented results show the performance of the system when locating the hook in 3D and the impact of attaching multiple tags to the hook to harness signal diversity. Specifically, a relatively lowerror is obtained when estimating only the height of the gantry crane hook (approximately 1 m), while the threedimensional positioning error reached an error of between 2 and 3m for the z-axis
Efficient Database Evolution in Digital Library Reengineering
Authors: Ramos-Vidal Delfina , Brisaboa Nieves R.
Published: November 2023

With the advancement of internet applications, extensive information systems were created to effectively manage and provide easy access to documents, which coincided with a global initiative to convert physical documents into digital format, making them accessible through the internet. After two decades, these databases are well-structured and organized, although the software used to manage them is gradually becoming outdated. Additionally, once the initial digitization and creation of metadata are completed, it is sensible to enhance the metadata further to provide more detailed information about the documents. In this article we propose a tool to facilitate the evolution of large documentary databases
Analysis of the NS-3 module QKDNetSim for the Simulation of QKD Networks
Authors: Soler David , Cillero Seijas Iván , Nóvoa Francisco , Dafonte Carlos , Fernández Vilas Ana , Fernández Veiga Manuel
Published: November 2023

Quantum Key Distribution (QKD) is a promising technology that allows two nodes to privately agree on a key through a quantum channel. Unfortunately, QKD is still in experimental phase and researchers must rely on simulators to replicate the behaviour of a quantum network. One of the most widespread is QKDNetSim, a module for the C++ network simulator NS-3. However, this module is very limited in its behaviour, so it does not faithfully represent a real quantum network. In this work we analyse the structure and components of QKDNetSim, as well as its shortcomings and how they affect the quality of the simulation
Virtual Reality for Cognitive Stimulation in the Elderly and Individuals with Disability
Authors: Fernández-Garrido Iago , Gómez Ángel
Published: November 2023

The recent advances in virtual reality enable the creation of highly realistic and immersive environments. The purpose of this project is to develop a virtual reality tool for cognitive stimulation in the elderly and people with disabilities through gamification. This tool will feature a range of activities, with adjustable difficulty levels and accessibility options. These activities can be combined with a 360º video to create a gymkhana or a circuit, providing users with an engaging and customized experience to enhance cognitive abilities and mental Agility
Enhancing Pathological Detection and Monitoring in OCT Volumes with Limited Slices using Convolutional Neural Networks and 3D Visualization Techniques
Authors: López-Varela Emilio , Barreira Noelia , Olivier Pascual Nuria , Penedo Manuel
Published: November 2023

Optical Coherence Tomography (OCT) is a non-invasive imaging technique with a crucial role in the monitoring of a wide range of diseases. In order to make a good diagnosis it is essential that clinicians can observe any subtle changes that appear in the multiple ocular structures, so it is imperative that the 3D OCT volumes have good resolution in each axis. Unfortunately, there is a trade-off between image quality and the number of volume slices. In this work, we use a convolutional neural network to generate the intermediate synthetic slices of the OTC volumes and we propose a few variants of a 3D reconstruction algorithm to create visualizations that emphasize the changes present in multiple retinal structures to aid clinicians in the diagnostic process
Embedded System for Monitoring and Prevention of Hardware/Software Incidents in Data Center Devices
Authors: Pérez Aboli Alberto , Dafonte Carlos , Gómez Ángel
Published: November 2023

Real-time monitoring of the status of the devices available in Data Centers (DC) is a critical task to try to provide quality services to customers, but also to detect possible hardware/- software incidents or to act against cyber-attacks. To perform these functions, there are specific system and network monitoring tools on the market that supervise different device functionalities (CPU, memory, storage, network, processes, services, etc.). However, these systems do not include the monitoring of basic elements for the correct operation of these devices, such as environmental parameters (power supply, temperature, humidity, noise, etc.). In this project we have designed and built a prototype embedded system, both hardware and software, to monitor in real time each device inside a rack and capable of integrating a wide variety of sensors. The hardware device is composed of: motherboard, power supply, infrared temperature sensor, noise level sensor, current consumption meter, 220VAC real input voltage meter, electronic module to switch on/off the 220VAC output and WiFi module to send the information
Performance of Xiaomi Mi Band 5 Against Polysomnography in Measuring Sleep
Authors: Concheiro-Moscoso Patricia , Groba Betania , Miranda-Duro María del Carmen , Alvarez-Estevez Diego
Published: November 2023

This study sought to compare the effectiveness of one of the top-selling activity wristbands, the Xiaomi Mi Band 5, with polysomnography in the measurement of sleep stages. Conducted at a hospital in A Coruña, Spain, this study recruited individuals already participating in a polysomnography study at a sleep unit. The study encompassed a total of 45 adults. The Xiaomi Mi Band 5 demonstrated an overall accuracy. Notably, it tended to overestimate total sleep time, light sleep, and deep sleep compared to polysomnography. Conversely, it underestimated wake after sleep onset and REM sleep measured by polysomnography. The Xiaomi Mi Band 5 holds potential as a tool for monitoring sleep and identifying alterations in sleep patterns, especially among individuals without sleep disorders. However, further research is warranted to evaluate its efficacy when used with individuals suffering from various types of sleep disorders
Reimagining Art: Virart, a Platform Using Virtual Reality for Creative Expression and Cultural Engagement
Authors: Donga João , Azevedo João , Carrapa Marta , Gomes Paulo Veloso
Published: November 2023

Virart is an immersive experience that showcase the potential of Virtual Reality in recreating artistic works. By leveraging the capabilities of VR, users can explore and interact with digital recreations of J ´ ulio Maria dos Reis Pereira artistic creations. The VR environment enhances the sense of presence and enables viewers to explore the art from different angles, offering a deeper level of engagement compared to traditional mediums. By showcasing the possibilities of virtual reality in recreating artistic works, Virart opens new avenues for artists, art enthusiasts, and the general public to appreciate and engage with art in innovative ways. It demonstrates the potential of virtual reality technology in preserving and promoting cultural heritage, allowing art to be experienced beyond physical limitations
De novel heterozygous copy number deletion on 7q31.31-7q31.32 involving TSPAN12 gene with familial exudative vitreoretinopathy in a Chinese family
Authors:   People's Hospital of Ningxia Hui Autonomous Region, Ningxia Medical University, Ningxia Eye Hospital, Ningxia Clinical Research Center on Diseases of Blindness in Eye, Yinchuan 750001, Ningxia Hui Autonomous Region, China, Zhang Shuang , Zou Gang ,   People's Hospital of Ningxia Hui Autonomous Region, Ningxia Medical University, Ningxia Eye Hospital, Ningxia Clinical Research Center on Diseases of Blindness in Eye, Yinchuan 750001, Ningxia Hui Autonomous Region, China, Ma Mei-Jiao ,   People's Hospital of Ningxia Hui Autonomous Region, Ningxia Medical University, Ningxia Eye Hospital, Ningxia Clinical Research Center on Diseases of Blindness in Eye, Yinchuan 750001, Ningxia Hui Autonomous Region, China, Rui Xue ,   People's Hospital of Ningxia Hui Autonomous Region, Ningxia Medical University, Ningxia Eye Hospital, Ningxia Clinical Research Center on Diseases of Blindness in Eye, Yinchuan 750001, Ningxia Hui Autonomous Region, China, Yang Shang-Ying ,   People's Hospital of Ningxia Hui Autonomous Region, Ningxia Medical University, Ningxia Eye Hospital, Ningxia Clinical Research Center on Diseases of Blindness in Eye, Yinchuan 750001, Ningxia Hui Autonomous Region, China, Sheng Xun-Lun ,   People's Hospital of Ningxia Hui Autonomous Region, Ningxia Medical University, Ningxia Eye Hospital, Ningxia Clinical Research Center on Diseases of Blindness in Eye, Yinchuan 750001, Ningxia Hui Autonomous Region, China
Published: November 2023

AIM: To investigate the genetic and clinical characteristics of patients with a large heterozygous copy number deletion on 7q31.31-7q31.32.
METHODS: A family with familial exudative vitreoretinopathy (FEVR) phenotype was included in the study. Whole-exome sequencing (WES) was initially used to locate copy number variations (CNVs) on 7q31.31-31.32, but failed to detect the precise breakpoint. The long-read sequencing, Oxford Nanopore sequencing Technology (ONT) was used to get the accurate breakpoint which is verified by quantitative real-time polymerase chain reaction (QPCR) and Sanger Sequencing.
RESULTS: The proband, along with her father and younger brother, were found to have a heterozygous 4.5 Mb CNV deletion located on 7q31.31-31.32, which included the FEVR-related gene TSPAN12. The specific deletion was confirmed as del(7)(q31.31q31.32)chr7:g.119451239_123956818del. The proband exhibited a phase 2A FEVR phenotype, characterized by a falciform retinal fold, macular dragging, and peripheral neovascularization with leaking of fluorescence. These symptoms led to a significant decrease in visual acuity in both eyes. On the other hand, the affected father and younger brother showed a milder phenotype.
CONCLUSION: The heterozygous CNV deletion located on 7q31.31-7q31.32 is associated with the FEVR phenotype. The use of long-read sequencing techniques is essential for accurate molecular diagnosis of genetic disorders.
Surgical outcome comparisons of multifocal IOLs of Lentis Comfort LS-313 MF15 and Tecnis Eyhance DIB00V
Authors:   Department of Ophthalmology, the Jikei University School of Medicine, Tokyo 105-8461, Japan, Sugawara Kyohei , Horiguchi Hiroshi ,   Department of Ophthalmology, the Jikei University School of Medicine, Tokyo 105-8461, Japan, Mizobuchi Kei ,   Department of Ophthalmology, the Jikei University School of Medicine, Tokyo 105-8461, Japan, Katagiri Satoshi ,   Department of Ophthalmology, the Jikei University School of Medicine, Tokyo 105-8461, Japan, Gunji Hisato ,   Department of Ophthalmology, the Jikei University School of Medicine, Tokyo 105-8461, Japan, Nakano Tadashi ,   Department of Ophthalmology, the Jikei University School of Medicine, Tokyo 105-8461, Japan
Published: November 2023

AIM: To compare the surgical outcomes of a multifocal intraocular lens (IOL; Lentis Comfort LS-313 MF15) with those of an enhanced monofocal IOL (Tecnis Eyhance DIB00V).
METHODS: This retrospective study included patients who underwent cataract surgery with LS-313 MF15 or Eyhance IOL implantation. Data regarding patient demographics, surgical records, and ophthalmic examination before the cataract surgery and one and three months postoperatively were collected. Visual acuities, refractive values, defocus curves, contrast sensitivities and subjective symptoms were evaluated.
RESULTS: Among the 71 eyes (47 patients) included in this study, 32 eyes (20 patients) underwent LS-313 MF15 IOL implantation, and 39 eyes (27 patients) underwent Eyhance IOL implantation. No significant differences were observed in age, axial length, or refractive error between the two groups preoperatively. Furthermore, the distance-corrected and uncorrected distance visual acuities one month postoperatively did not differ between the groups, and both groups had sufficient visual acuities at the distances of 5, 1 m, 70, 50, and 30 cm. Other ophthalmic data, including subjective symptoms based on the 14-item Visual Function Index Questionnaire, monocular defocus curves, contrast sensitivities, and halo and glare, did not differ between the groups three months postoperatively. Moreover, both groups had good outcomes. The spherical equivalent one month postoperatively was significantly myopic in the LS-313 MF15 group compared with that in the Eyhance group (P=0.033); however, this difference was not observed three months postoperatively (P=0.471).
CONCLUSION: Comparison of the surgical outcomes of LS-313 MF15 with those of Eyhance with different optical properties reveal that both IOLs show good postoperative outcomes, with no significant differences being noted between the two IOLs.
Risk factors and prognosis of pediatric rhegmatogenous retinal detachment in Egypt: a university hospital based study
Authors:   Department of Ophthalmology, Kasr Al Ainy Hospital, Faculty of Medicine, Cairo University, Cairo 11431, Egypt, Eissa Mohamed Gaber , Macky Tamer Ahmed ,   Department of Ophthalmology, Kasr Al Ainy Hospital, Faculty of Medicine, Cairo University, Cairo 11431, Egypt, Mortada Hassan Aly ,   Department of Ophthalmology, Kasr Al Ainy Hospital, Faculty of Medicine, Cairo University, Cairo 11431, Egypt
Published: November 2023

AIM: To study and compare the predisposing factors and clinical features of pediatric, adult, and elderly rhegmatogenous retinal detachment (RRD).
METHODS: This is an observational analytic cross-sectional study in which patients with RRD admitted for surgery during 6mo period were divided into 3 age groups: pediatric (<18y), adult (18-60y), and elderly (>60y). Patients' demographic data, clinical features, RRD predisposing factors/features including myopia (axial length ≥26.5 mm), aphakia/pseudophakia, blunt trauma, peripheral retinal degenerations, history of RRD in the fellow eye, and surgical interventions/findings were recorded and analyzed.
RESULTS: Totally 142 patients (142 eyes) were studied: 26 (18.31%) pediatrics, 86 (60.56%) adults, and 30 (21.13%) elderly. Elderly patients had a significantly higher intraocular pressures and cataracts compared to the other 2 groups (P=0.04). The RRD extent was larger in pediatric group (mostly 4 quadrants) compared to adults and elderly (mostly 2 quadrants), but it was not statistically insignificant (P=0.242). There were not statistically significantly differences in proliferative vitreoretinopathy (PVR) rate, posterior vitreous detachment (PVD) rate, number, site, shape, and size of breaks in three groups. All three groups had macular detachment in all eyes. Myopia and peripheral retinal degenerations were found to be more significant in adults (P=0.049, P=0.035, respectively), while blunt trauma was higher but insignificant in pediatric eyes (P=0.052). Pars plana vitrectomy (PPV) with silicone oil as a tamponade was the most used surgery in all groups.
CONCLUSION: There are no significant difference in PVR rate in pediatric eyes but a significant higher rate of total RRD. Blunt trauma is more frequent in pediatrics eyes while myopia and/or peripheral retinal degenerations are more frequent in older ages. The rate of PPV as a choice for surgery is similar among all age groups.
Optical coherence tomography angiography for macular microvessels in ischemic branch retinal vein occlusion treated with conbercept: predictive factors for the prognosis
Authors:   Department of Ophthalmology, the Affiliated Eye Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China, Tang Li , Zhao Yue ,   Department of Ophthalmology, the Affiliated Eye Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China, Yang Ting-Ting ,   Department of Ophthalmology, the Affiliated Eye Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China, Yao Jin ,   Department of Ophthalmology, the Affiliated Eye Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Published: November 2023

AIM: To evaluate the predicative factors of visual prognosis using optical coherence tomography angiography (OCTA) in ischemic branch retinal vein occlusion (BRVO) patients with macular edema (ME) after anti-vascular endothelial growth factor (VEGF) treatment.
METHODS: In this retrospective analysis, data from 60 patients (60 eyes) with a definite diagnosis of ischemic BRVO with ME by fundus fluorescein angiography (FFA) were studied. The eyes with ME according to spectral domain optical coherence tomography (SD-OCT) underwent intravitreal conbercept (IVC) and 3+pro re nata (PRN) regimen. The injection times were recorded. Two weeks after injection, fundus laser photocoagulation was performed in the non-perfusion area of the retina. The patients were followed up once a month for 6mo. The best-corrected visual acuity (BCVA), foveal avascular zone (FAZ), and A-circularity index (AI), at 6mo and the baseline were compared.
RESULTS: All patients showed significant improvement in BCVA from 0.82±0.32 to 0.39±0.11 logMAR (P<0.001). The mean central macular thickness (CMT) significantly decreased from 476.22±163.54 to 298.66±109.23 μm. Both the FAZ area and AI at 6mo were significantly higher than those at the baseline: the FAZ area increased (0.38±0.02 vs 0.39±0.02 mm², P<0.05); the AI increased (1.27±0.02 vs 1.31±0.01, P=0.000). The baseline BCVA showed a significantly positive correlation with the baseline FAZ area, FAZ perimeter (PERIM) and AI, final visual gain (FVG) and injection times, respectively (P<0.001). FVG showed a significantly negative correlation with the FAZ area, PERIM, AI and injection times, but a significantly positive correlation with vessel densities (VDs) 300 µm area around FAZ (FD-300; P<0.001). Injection times was positively correlated with the baseline FAZ area, and AI, but inversely correlated with the baseline FD-300 (P<0.001). However macular ischemia was noted in 5 cases during follow-up.
CONCLUSION: Using OCTA to observe macular ischemia and quantify parameters can better predict the final visual prognosis of patients before treatment. The changes in FAZ parameters may influence the visual prognosis and injection times.
COVID-19 e sarcopenia em idosos: revisão integrativa
Authors: Alves Fillipe Augusto Felix , Boas Thales Augusto Villas , Kovelis Demetria
Published: November 2023

O número de novos casos de diagnóstico de covid-19 aumentou drasticamente nos últimos tempos, somando aproximadamente 235 milhões de indivíduos confirmados ao redor do mundo. Ao verificar a incidência da doença juntamente com o número de óbitos em decorrência da mesma, é possível observar uma maior mortalidade em idosos O fator influenciador da vulnerabilidade nesta população consiste em alterações fisiológicas dos sistemas orgânicos do corpo, em especial, a sarcopenia referente ao sistema muscular. Objetivo: Analisar o impacto da covid-19 em pessoa idosa e qual a sua relação com o desenvolvimento e agravamento da sarcopenia em indivíduos senis. Método: O estudo é caracterizado como uma revisão integrativa. Resultados: Após a revisão e leitura de acordo com os critérios do estudo, sete artigos foram elegíveis, destes três abordavam a relação direta da diminuição da composição muscular com a covid-19, outros dois artigos expuseram a forma que a pandemia da covid-19 impactou a vida dos idosos e dois demonstraram a influência do exercício físico em idosos e sua importância durante a pandemia Conclusão: Os idosos com diminuição da massa magra estão mais propensos a sintomas graves, internação e até mesmo a óbito, após contaminação covid-19. Além disso, o isolamento social, necessário para a contenção do vírus, proporcionou grande impacto negativo nos aspectos físicos e emocionais da população estudada. Desta forma, fica evidente a necessidade da prática de exercícios físicos, com as devidas precauções, para esse grupo diminuir ao máximo os riscos associados à sarcopenia.
تحقيق رسالة «الياقوتة الحمراء» لمحمَّد طاهر بن محمَّد لَالَه‌زَارِي (ت. 1204هـ/1789م)
Authors: Ağbal Davut
Published: November 2023

تتناول هذه المقالة الرِّسالة المسمَّاة بــالياقوتة الحمراء لمحمَّد طاهر بن محمَّد لَالَه‌زَارِي أحد علماء العثمانيِّين في القرن الثامن عشر، لَالَه‌زَارِي الذي لا تتوفَّر معلومات تفصيليَّة عن حياته ومع ذلك ترك خلفه رسائل كثيرة وكتبًا، جُمعت أغلبيَّة رسائله في مجموعة اسمها مجمع أسرار الجواهر الرُّوحانيَّة في مطلع الأنوار الزَّواهر الرَّيحانيَّة من قبل المؤلِّف، الرِّسالة التي هي موضوع هذه المقالة هي الرِّسالة الثَّالثة من هذه المجموعة، الياقوتة الحمراء تشرح بعض الجمل في تأويلات القرآن لأبي منصور الماتريدي (ت. 333ه/944م) في تفسير الآية الخامسة من الفاتحة. إنَّ النَّصَّ المنقول من الماتريدي يتناول "الاستثناء في الإيمان" أحد الموضوعات الكلاميَّة إجمالًا، لَالَه‌زَارِي أوَّلًا شرح هذا النَّصَّ؛ وبعده فصَّل الموضوع بأسلوب السُّؤال والجواب، وقد يرى أنَّ الشَّارح تعامل مع الموضوع المذكور من وجهة نظر تصوُّفيَّة في الرِّسالة، في هذه المقالة التي تهدف إلى تسليط الضوء على شخصيَّة لَالَه‌زَارِي العلميَّة والفترة التي عاش فيها تمّ التَّثبيت من أنّ لَالَه‌زَارِي لم يأت بفكرة جديدة. وعلى الرغم أنَّه ترك وراءه آثارًا كبيرة وصغيرة في مجالات مختلفة كان عدد قليل من مؤلَّفاته موضوع دراسات أكاديميَّة فقط؛ لكنَّ الرِّسالة مهمَّة لكونها واحدة من التَّآليف المحدودة على تأويلات القرآن من ناحية، ومن ناحية أخرى الكشفُ عن مثل هذه الآثار يساعد على فهم التراث الفكري العثماني بشكل أوضح.
Propafenone Induced Takotsubo Cardiomyopathy: A Mere Coincidence or A New Causal Relationship?
Authors: ÇAKAN Fahri , ADAR Adem
Published: November 2023

Propafenone is a class 1C antiarrhythmic drug that blocks sodium channels and is used in the treatment of arrhythmia. Because of its rapid effect on terminating paroxysmal episodes of atrial fibrillation, it can be used as a pill-in-the-pocket. In patients with structural heart disease, it is less preferred due to cardiotoxic effects in long-term use. Although propafenone use is known to cause several cardiovascular side effects, the development of Takotsubo cardiomyopathy is unknown. Propafenone toxicity at standard doses is a rare condition. Propafenone plasma concentrations may increase through inhibition of cytochrome P450 2D6 and complete inhibition of 2D6 metabolism can increase propafenone levels by up to 3 to 10 times. In this case report, we aimed to present a 37-year-old female patient who developed Takotsubo cardiomyopathy and cardiogenic shock after the first dose of propafenone use and recovered with medical treatment.
Quality Evaluation of Fish Powder Developed from Labeo bata, a Minor Carp of Assam
Authors: Tiwari Mansi , Bordoloi Premila L. , Barooah Mridula Saikia
Published: November 2023

Background: Assam being a riverine state is home to n4umerous fish species that has been relished on for generations. However, fish being a perishable item, they need to be preserved for their availability throughout the year and to minimise wastage. The fish Labeo bata is a freshwater medium sized Indian minor carp which is very popular among the locals because of its characteristic taste and their high health ameliorating effects. Therefore, considering these facts, the present study focused on preparation and quality evaluation of fish powder from a minor carp, Labeo bata. Methods: Fresh fish collected from local fish market of Raha, Nagaon, Assam were dressed, washed and dehydrated to prepare fish powder. The prepared fish powder was evaluated for their nutritional composition, functional properties, sensory properties and shelf life as per standard protocols. Result: The results indicated that the moisture, protein, fat and ash content of prepared fish powder was 4.52, 63.87, 13.04 and 2.96 g/100 g respectively. The prepared flour had superior functional characteristics with bulk density, water absorption capacity, fat absorption capacity and foaming capacity of 0.53 g/ml, 145.00 ml/00 g, 99.00 ml/100 g and 32.20 per cent respectively. The product also displayed good shelf life when evaluated in terms of changed in moisture, free fatty acid (FFA), peroxide value (PV), total plate count (TPC) and pH across storage for a period of 90 days. The change in moisture, FFA, PV, TPC and pH content varied from 4.52-5.40 g/100 g; 0.08-0.22 per cent; 1.00-4.11 mEq O2/Kg; 3.12-4.23 log cfu/g and 6.22-6.80 respectively.
Proximate, Functional and Sensory Analysis of Quinoa and Wheat Flour Composite Cake
Authors: Olawuni I.A. , Uzoukwu A.E. , Ibeabuchi J.C. , Ofoedum A.F. , Nwakaudu A.A. , Alagbaoso S.O. , Anaeke E.J. , Ugwoezuonu J.N.
Published: November 2023

Background: Confectionaries are one of the major food categories that provides one of the basic nutritional needs of humans. Cake has always been made from flour, as such, has placed a heavy burden of wheat production. However, quinoa seeds have been under-utilized owing to its nutritional components and the need to produce baked products with balanced nutritional needs.
The goal of this study was to develop a high-protein cake using a protein source. Quinoa flour was employed as a protein source. Methods: The quinoa seeds were ground into flour and combined with wheat flour in the following ratios: 30:70, 40:60 and 50:50, in that order. A cake made entirely of wheat flour served as the control. Sensory analyses were conducted on the samples, as well as functional and proximate compositions, using standard analytical techniques. Result: The research’s findings revealed that moisture ranged from 33.61% to 43.99%, protein ranged from 13.60% to 18.03%, ash ranged from 0.91% to 1.211%, fiber ranged from 5.25% to 5.77%, fat ranged from 5.54% to 6.25% and carbohydrate ranged from 30.59% to 39.81%. Comparing samples of composite flour cakes to samples of wheat flour cakes revealed a difference in the amount of total protein that was statistically significant (p less than 0.05), indicating that these cakes make a great source of protein for fortified snacks.
Bonuszahlungen an Manager : Eine Szenarienanalyse zu Gerechtigkeitsurteilen von Beschäftigten
Authors: Gückelhorn Cathrin , Struck Olaf , Dütsch Matthias , Stephan Gesine
Published: November 2023

Bonuszahlungen im Top-Management haben in den letzten Jahren zugenommen – genauso wie die öffentliche und politische Debatte darüber. Vor diesem Hintergrund geht der Aufsatz der Frage nach, wann Beschäftigte Bonuszahlungen an Manager als gerecht bzw. ungerecht einschätzen. Hierzu greift der Artikel auf Theorien und Ansätze der empirischen organisationalen Gerechtigkeitsforschung zurück. Datengrundlage ist eine repräsentative telefonische Befragung, in der die Teilnehmenden hypothetische Szenarien in Form von Vignetten bewerteten. Die Auswertungen zeigen, dass Situationsmerkmale im Vergleich mit soziodemografischen Merkmalen der Befragten einen starken Einfluss auf die Gerechtigkeitsurteile haben. Eine korrespondierende Erfolgsbeteiligung der Belegschaft kann demnach zur Akzeptanz von Bonuszahlungen führen. Geringere Einflüsse gehen hingegen von einer Berücksichtigung der Belegschaftsinteressen bei Entscheidungen des Managements, umfangreichen Informationen, dem Unternehmenserfolg sowie der Bonushöhe aus. Die Verantwortung des Top-Managements sowie ein Hinweis auf die Branchenüblichkeit der Bonuszahlungen besitzen keinen Einfluss. Insgesamt liefert der Beitrag damit neue Erkenntnisse zu Fragen der sozialen Gerechtigkeitund gibt Anregungen zur fairen Ausgestaltung von Bonuskomponenten.
The Australian landscape of newborn screening in the genomics era
Authors: Ji Charli , Farrar Michelle A , Norris Sarah , Bhattacharya Kaustuv , Bennetts Bruce , Newson Ainsley J , Healy Louise , Millis Nicole , Kariyawasam Didu S
Published: November 2023

In Australia, over 300,000 newborns undergo newborn bloodspot screening (NBS) annually, with approximately 1 in 1,000 identified with a rare but actionable condition through this pathway. Prior to 2018, the inclusion criteria for adding conditions in NBS panels was inconsistent nationally, leading to the development of the Australian National Newborn Bloodspot Screening Policy Framework. This framework promotes systematic and evidence-based inclusion of conditions using criteria closely informed by traditional Wilson and Junger screening principles. Current policy initiatives are focused on achieving national consistency in the conditions screened. NBS programs, initiated in the 1960s, have used a variety of techniques, including but not limited to tandem mass spectrometry and immunological assays. The acceleration of genomic technologies has the potential to greatly increase the number of conditions screened and match affected newborns with innovative treatment options, including advanced (gene, immune modulation, and RNA) therapies. This review describes the evolution, current status quo, and outlook for Australian NBS programs with a focus on the implications of wider adoption of genomic newborn screening (gNBS) in our culturally, geographically, and genetically diverse population. We discuss the potential for transformative benefits for families with children identified by gNBS and how this must be balanced against the potential for a range of unintended negative consequences. We emphasise the importance of a nationally agreed, coordinated, and streamlined approach to the addition and removal of conditions from Australian NBS programs, which considers the utility, cost, ethical, and equity aspects of gNBS.
Empirical Study on the Analysis of the Financial Auditor`s Concern in Ensuring the Transparency and Sustainable Performance of BSE Listed Companies
Authors:   Faculty of Economics and Business Administration, “Alexandru Ioan Cuza” University of Iasi, Romania, GROSU Maria , ISTRATE Costel ,   “Alexandru Ioan Cuza” University of Iasi, Faculty of Economics and Business Administration, Romania, ROBU Ioan-Bogdan ,   Faculty of Economics and Business Administration, “Alexandru Ioan Cuza” University of Iasi, Romania
Published: November 2023

Sustainable development of the company implies achieving a balance in terms of economic, social and environmental activities with the aim of making optimal use of the entity's resources without harming the environment and through an active involvement of the company in society. To this end, an important role is played by the financial auditor, the guarantor of transparency in financial reporting and an active player in enforcing discipline in sustainable reporting. Through the audit report, including the opinion expressed, the auditor contributes to the credibility of the audited financial statements and inspires confidence in all users. The purpose of this study is to test the influence of the audit opinion and the auditor's membership of the Big4 group of companies on key indicators of financial position and performance, as well as on the use of performance management operations. The study also tested the influence of the audit opinion, in conjunction with the influence of key financial indicators, on the probability of reporting Key Audit Matters (KAM) related to earnings management operations or going concern. The study was conducted at the level of Romanian companies listed on the Bucharest Stock Exchange (BSE) – Regulated Market, in the period 2012-2022. Using advanced statistical methods of data analysis, the main results of the study indicate the existence of a significant influence of the previous year's audit opinion expressed by a particular type of auditor on key indicators of financial position and performance, as well as on discretionary accruals. At the same time, the prior year audit opinion as well as the current year values of the key financial indicators analysed have a significant influence on the probability of reporting on Key Audit Matters (KAM) related to earnings management operations or going concern.
Flutter of a Plate at High Supersonic Speeds
Authors: Sezgin Aziz , Durak Birkan , Sayın Alaattin , Yildiz Huseyin , Ozer Hasan Omur , Sakman Lutfi Emir , Kapkin Sule , Uzal Erol
Published: November 2023

Vibrations of plate structures placed in a supersonic flow is considered. The undisturbed fluid flow is parallel to the plate. Two specific problems are treated: in the first one the plate is in the form of an infinite strip and the flow is in the direction of its finite length. Rigid walls extend from the sides of the plate indefinitely. In the second problem, the plate is a finite rectangle and the flow is parallel to one of its sides. The first problem is a limiting case of the second problem. The flow is modeled by piston theory which assumes that the fluid pressure on the plate is proportional to local slope. This approximation is widely used at high speeds, and reduces the interaction between the fluid flow and the vibrations of the plate to an additional term in the vibration equation. The resulting problem can be solved by assumed mode methods. In this study, the solution is also carried out by using the collocation method. The main result is the flutter velocity of the free fluid flow under which the plate vibrations become unstable. Finally, simple expressions are proposed between the various non-dimensional parameters that allows quick estimation of flutter velocity.
Naples Prognostic Score Is a Useful Tool to Assess the Surgical Treatment in Non-small Cell Lung Cancer
Authors: Elia Stefano , Patirelis Alexandro , Hardavella Georgia F. , Santone Antonella , Carlea Federica , Pompeo Eugenio
Published: November 2023

Different prognostic scores have been applied to identify patients with non-small cell lung cancer who have a higher probability of poor outcome. In this study we evaluated whether Naples Prognostic Score, a novel index which considers both inflammatory and nutritional values, was associated with long-term survival. The study is a retrospective propensity score matching analysis of patients who underwent curative surgery for non-small cell lung cancer from January 2016 to December 2021. The score considered four pre-operative parameters: neutrophil to lymphocyte ratio, lymphocyte to monocyte ratio, serum albumin and total cholesterol. Kaplan-Meier method and Cox regression analysis were performed to evaluate the relation between the score and disease-free survival, overall survival and cancer-related survival. A total of 260 patients were selected for the study, reduced to 154 after propensity score matching. Post-propensity Kaplan-Meier analysis showed a significant correlation between Naples Prognostic Score and overall survival (p=0.018) and cancer-related survival (p=0.007). Multivariate Cox regression analysis further validated the score as an independent prognostic indicator for both these survivals (p=0.007 and p=0.010 respectively). Naples Prognostic Score proved to be an easily achievable prognostic factor of long-term survival in patients with non-small cell lung cancer after surgical treatment.
Is Physical Activity an Efficient Strategy to Control the Adverse Effects of Persistent Organic Pollutants in the Context of Obesity? A Narrative Review
Authors: Serrano Quentin Alexis , Le Garf Sébastien , Martin Vincent , Colson Serge Sébastien , Chevalier Nicolas
Published: November 2023

Obesity affects nearly 660 million adults worldwide and is known for its many comorbidities. Although the phenomenon of obesity is not fully understood, science regularly reveals new determinants of this pathology. Among them, the persistent organic pollutants (POPs) have been recently highlighted. Mainly lipophilic, POPs are normally stored in adipose tissue and can lead to adverse metabolic effects when released into the bloodstream. The main objective of this narrative review is to discuss the different pathways by which physical activity may counteract POPs adverse effects. The research that we carried out seems to indicate that physical activity could positively influence several pathways negatively influenced by POPs, such as insulin resistance, inflammation, lipid accumulation, adipogenesis and gut microbiota dysbiosis that are associated with the development of obesity. This review also indicates how, through the controlled mobilization of POPs, physical activity could be a valuable approach to reduce the concentration of POPs in the bloodstream. These findings suggest that physical activity should be used to counteract the adverse effects of POPs. However, future studies should accurately assess its impact in specific situations such as bariatric surgery where weight loss promotes POPs blood release.
Identification of an Ortholog of MALT1 from Shrimp that Induces NF-κB Mediated Antiviral Immunity
Authors: Wang Haiyang , Xiao Bang , Chen Shihan , He Jianguo , Li Chaozheng
Published: November 2023

MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) serves as a pivotal mediator for NF-κB activation in response to a wide spectrum of transmembrane receptor stimuli. In the present study, a homolog of MALT1 is cloned from the Pacific white shrimp (Litopenaeus vannamei) named LvMALT1, and its potential function in shrimp innate immunity are explored. The open reading frame of LvMALT1 is 2364 bp that encodes 787 amino acids. The predicted LvMALT1 protein structure comprises a death domain, three immunoglobulin domains, and a caspase-like domain, exhibiting remarkable similarity to other homologs. LvMALT1 is a cytoplasmic-localized protein and could interact with LvTRAF6. Overexpression of LvMALT1 induces the activation of promoter elements governing the expression of several key antimicrobial peptides (AMPs), including Penaeidins (PENs) and Crustins (CRUs). Conversely, silencing of LvMALT1 leads to a reduction in the phosphorylation levels of Dorsal and Relish, along with a concomitant decline in the in vivo expression levels of multiple AMPs. Furthermore, LvMALT1 is prominently upregulated in response to a challenge by the white spot syndrome virus (WSSV), facilitating the NF-κB-mediated expression of AMPs as a defense against viral infection. Taken together, we identified a MALT1 homolog from shrimp L. vannamei, which plays a positive role in the TRAF6/NF-κB/AMPs axis mediated innate immunity.