bluuebunny/crossref_metadata_2025 huggingface dataset:
Targeted Literature Review of Outcomes to Initial Systemic Therapy for Advanced/Metastatic Non-Clear Cell Renal Cell Carcinoma in Observational Studies
Authors: Calhoun Shawna R. , Sharma Manish , Lee Chung-Han
Published: September 2023

Background:

Non-clear cell renal cell carcinoma (nccRCC) is a diverse group of cancers that occurs in approximately 25% of patients with renal cell carcinoma. In the advanced/metastatic setting, survival in all nccRCC subtypes is considered poor, due to the inherent aggressiveness of these cancers, and a lack of effective systemic treatment options. Clinical trials of immune/targeted agents have predominantly focused on patients with ccRCC. There is no globally accepted standard of care for nccRCC; however, recently clinical trials have been initiated in this population.

Objective:

To perform a targeted literature review of published original observational studies reporting common real-world clinical outcomes (real-world overall response rate [rwORR], real-world progression free survival [rwPFS], real-world overall survival [rwOS]) in previously treatment naïve patients with advanced/metastatic nccRCC.

Methods:

A targeted search of MEDLINE and EMBASE was conducted per PRISMA guidelines to identify observational studies in previously treatment naïve patients with advanced/metastatic nccRCC. Publications with adequate information since 2010 and from select conferences since 2020 were considered.

Results:

27 studies across 29 publications were identified. Sample sizes ranged from 7-1,573 across these studies with differences in nccRCC subtypes included and treatments received. Real-world ORR ranged from 0–37%, median rwPFS from 2–17 months, and median rwOS from 3–30 months, across 19, 17, and 24 studies, respectively. These outcomes also varied with receipt/type of treatment and demographic/clinical subgroups with outcomes tending to be worse in patients with papillary RCC compared to chromophobe RCC.

Conclusions:

Clinical outcomes varied, as patient populations, eligible histologies, treatments and methods were heterogeneous.
Revolutionizing engineering education: Creating a web-based teaching platform for immersive learning experiences
Authors: Mouttalib Houda , Tabaa Mohamed , Youssefi Mohamed
Published: September 2023

Innovative pedagogy is more oriented towards the use of new technology in future education. Virtual and augmented realities, as well as the metaverse, are today the catalysts for the development of future teaching tools. They allow students to discover, via their smartphones or headsets, destinations around the world while remaining in their classrooms or even from their homes. These technologies are also used to put into practice, especially for the engineering sciences, lessons, and practical work by creating immersive experiences for users. This will significantly change the role of the teacher and the student in digital spaces. The realization of VR or AR learning platforms requires multidisciplinary skills ranging from 3D modeling to web and mobile platforms. In this paper, we present a method for creating a teaching platform for engineering sciences based on WebXR. We have created in our virtual environment a lesson about the Arduino board to train STEM students.
Prevalence and predictors of burnout among nurses during the COVID-19 pandemic: A survey in teaching hospitals1
Authors: Raei Mehdi , Shahrbaf Mohammad Amin , Salaree Mohammad Mehdi , Yaghoubi Maryam , Parandeh Akram
Published: September 2023

BACKGROUND: Occupational burnout is one of the most important consequences of the coronavirus disease pandemic, associated with psychological well-being, quality of care, and intention to leave the nursing profession. This is a major health problem with serious adverse consequences not only for nurses but also for patients and healthcare systems. OBJECTIVE: To assess burnout and its associated factors in nurses who worked in teaching hospitals during the COVID-19 pandemic in Iran. METHODS: A cross-sectional study was conducted on nurses of two COVID-19 referral hospitals in Tehran, Iran. Data were collected using the sociodemographic form and Maslach burnout inventory-human service survey (MBI-HSS) questionnaire. Data were evaluated using SPSS software version 26. RESULTS: A total of 264 participants, 52.7% (n = 139) were males and the mean of them age was 34.41±9.71 years. Almost 50% of nurses experienced burnout, in each dimension. Emotional exhaustion was associated significantly with job retention intention (P = 0.01) and depersonalization was significantly associated with gender (P = 0.02), age (P = 0.01), educational level (P = 0.004), work shifts (P = 0.006), and job retention intention (P = 0.02). In addition, personal accomplishment score was significantly associated with age (P = 0.002), marital status (P = 0.03), educational level (P = 0.03), work shift (P = 0.04) and job retention intention (P = 0.01). CONCLUSION: The burnout rate in the COVID-19 era is high among nurses associated with improper care. Psychosocial support is needed to improve mental well-being among health care workers during unpredictable conditions like pandemics.
KEDUDUKAN LEMBAGA NEGARA ANTARA INDONESIA DENGAN FILIPINA
Authors: Hermawati Nety , Lia Desta , Octora Nency
Published: September 2023

In a democratic country, it must have a system or constitutional order and there is a separation of powers. This relates to the institutions that exist in a sovereign country, namely the Indonesian state and the Philippines. Bearing in mind that the states of Indonesia and the Philippines are countries based on democratic law, the existence of a representative institution can be an alternative as well as a liaison between the state and its people or community aspirators in order to achieve a sovereign society. The method in this study uses a comparative research method, namely comparing an object with other objects in this case discussing state institutions between Indonesia and the Philippines.
Hubungan Pengawasan Pelaksanaan Pilkada Dengan Money Politics
Authors: Irawan Hendra
Published: September 2023

Pilkada di Indonesia telah mengalami beberapa kali perubahan dalam pelaksanaan pemilu. Oleh karena itu saat ini pelaksanakan pemilu dilaksanakan secara langsung mulai dari presiden, DPR, gubernur, bupati/walikota, hingga kepala desa. Dengan memilih langsung diharapkan individu-individu lokal maupun nasional dapat menemukan pemimpin yang sesuai dengan aspirasi mereka. Namun seringkali yang saat ini terjadi dalam Pemilihan Kepala Daerah dengan pemberia n uang maupu n jasa guna mempegaruhi piliha n pemili h memang kera p terjadi dala m pemilu karena diangga p sebagai strategi yang menjanjika n dala m mempengaruhi piliha n masyarakat da n muda h untu k dilakuka n karena sika p aka n keterbukaa n masyarakat terhada p Money Politics semaki n meningkat. Berdasarkan kajian bahwasanya akar permasalahan munculnya politik uang adalah kandidat dan masyarakat yang memiliki perilaku kapitalis didasarkan pada untung dan rugi secara ekonomi. Sementara celah hukum, pengawasan yang lemah dan sistem pemilu proporsional membuka peluang berkembangnya politik uang.
Authors: Rizqi Retanisa , Safitri Khansa Kamila , Muntaha Muslih Al
Published: September 2023

Abtrak : 

Sistem khilafah jika di terapkan di Indonesia menggunakan perspektif Resolusi Konflik. Penelitian ini menggunakan metode penelitian library research. Sistem khilafah berbeda dengan bentuk pemerintahan lainnya, seperti monarki, republik, atau federasi. Sistem khilafah tidak dapat dilaksanakan dengan menggunakan kekerasan, melainkan melalui cara-cara yang halal atau dengan meminta bantuan dari Ahl al-Nusrah yang identik dengan Ahlul Quwwah. Di Indonesia, terdapat ratusan suku, adat, dan kepercayaan yang berbeda, semuanya hidup berdampingan dengan damai. Bangsa ini diciptakan dengan semangat toleransi dan keberagaman. Oleh karena itu, para pemimpin pendiri bangsa ini menanamkan Pancasila dan UUD 1945 dengan semangat kebhinekaan dan toleransi tersebut. Negara Indonesia terdiri dari berbagai macam agama yang berbeda, sehingga tidak bisa di terapkan sistem syariat Islam atau khilafah. Pancasila yang ada saat ini sudah menjadi ideologi yang tepat untuk diterapkan di Indonesia.
Modernization of electrical equipment as a way of reducing the risks of emergency situations at nuclear power plants
Authors: Levchenko Larysa O. , Radionov Oleksandr V.
Published: September 2023

An analysis of major accidents in the electric power and coal industry was carried out. It is shown that for many types of technological equipment, the cause of failure was the unsatisfactory performance of the seals. It is shown that in two known nuclear accidents, the cause is the failure of coolant supply systems. Moreover, it had catastrophic consequences at the Fukushima nuclear power plant. The direct cause of the cessation of cooling of the reactors was the ingress of water into the electric motors of the circulation pumps. Most electric drives of nuclear power plants are synchronous electric motors. Turbogenerators are also synchronous four-pole electric machines of great value, which determines the expediency of increasing their reliability and service life. The solution to this problem is possible with the help of magnetic fluid sealing complexes (MFCs). To compare the level of man-made safety when using MFCs and traditional sealing systems, an improved method of risk assessment is proposed, developed at the expense of a systematic analysis of sealing complexes of equipment of hazardous industries for synchronous electric motors of the SDN type under different modes of operation, power and revolutions of the rotating shaft. The man-made risk assessment shows that the level of man-made danger is reduced by 1.5 to 4 times when sealants are introduced.
Transmission of information in automated special purpose systems
Authors: Dovgiy Stanislav O. , Kopiika Oleh V. , Kozlov Oleksii S.
Published: September 2023

This paper is devoted to solving the problem of optimizing the message transport service, which is one of the basic for automated special purpose systems. The NATO model of network-centric transformation of automated control and communication systems, which is presented in the form of a general plan for the development of information systems, was taken as the basis for the construction of special-purpose systems. An analysis of the development of information systems was carried out within the framework of the program of modernization and improvement of automated management systems. Under this program, large-scale work was carried out on the creation of new mobile nodes and means of communication for the perspective automated communication system at the tactical level Warfighter Information Network-Tactical. Therefore, it is proposed to use wireless, decentralized, mobile IP networks such as MANET (Mobile Ad hoc Network) for automated special purpose systems at the tactical level. Each of the mobile devices of such network can move independently in any direction, and, as a result, often break and establish connections with neighbors. For the MANET network the messaging service is considered in the context of: one automated workplace, one domain and interconnection between domains. The efficiency of information transmission systems is considered. Circular transmission algorithms for messages with the highest urgency category are defined and a control algorithm is provided for selecting the optimal message transmission channel in which the time spent on message transmission between these subscribers is minimal (dynamic programming problem with additive effect function). Bellman's functional equation for the conditional optimization stage was adapted for this problem.
SEMIOTIC APPROACH IN THE ARCHITECTURE OF CENTRAL CROSS-SHAPED ORTHODOX CHURCHES
Authors: Khaidukov Vladyslav
Published: September 2023

The scientific research highlights the problem of shaping in the cruciform Orthodox churches architecture and the placement of this type of sacred structures in accordance with urban planning and natural conditions. It is revealed the three-dimensional solution of the temple, in which the supporting structures form an architectural space based on the three-dimensional cross symbol. The cross-dome system, which became widespread in the cruciform Orthodox churches architectural structures, was developed in the early Byzantine era. Probably, its origin is based on the late antiquity architecture in the form of reconstruction of ancient Roman temples and Syrian religious buildings. Later it spread to the Caucasus, Palestine and North Africa, the Balkans and, further, to the ancient Rus' territory. The use of relatively new structures will be relevant for the Orthodox churches design in difficult geological conditions or the disclosure, if necessary, of a more complex architectural image. One of the sacred architecture features is the architectural image formation through the sacred symbols use. It is proposed to use the cross symbol in accordance with the name of Orthodox churches. For this purpose, it is identified cross symbol typological groups, divided into two main epochs: pre-Christian and Christian. It is  defined the typological groups used in Orthodox architecture, which are divided into five periods. Some of the cross symbol typological groups are presented below in the conceptual model of a centric cruciform Orthodox church. It is identified five main signs of the cross symbol use in an Orthodox church: in the architectural space, exterior, interior, plan, and facade shaping. It is provided a conceptual model of a centric cruciform Orthodox church, in which all five main features of the cross symbol use in an Orthodox church are implemented.
PROBLEMS OF REVITALIZATION OF FACILITIES OF THE SUBJECT-SPATIAL ENVIRONMENT AND MODERN BUILDING IN THE HISTORICAL PART OF SMALL TOWNS
Authors: Stepanyuk Andrii , Kiuntsli Romana
Published: September 2023

The revitalization of objects of the subject-spatial environment and the construction of modern buildings in the historical environment of settlements is a complex task that causes numerous discussions. This process is often accompanied by sharp accusations, in which the main argument sounds quite convincing: new buildings and structures disturb the authentic atmosphere of the old buildings.

Cities that are on the list of historical ones, according to the Law of Ukraine «On the Protection of Cultural Heritage», require a special approach to their preservation and spatial development. The legislation regulates the construction of such cities in the historical environment through the so-called historical areas, historical and architectural reserves, the allocation of protected areas, complex protection zones, and development regulation zones.

The introduction of security restrictions contributes to the preservation of the historical architectural and urban structure of such cities, but at the same time restrains new construction and restoration and reconstruction of abandoned buildings and structures. Thus, due to these restrictions, after many years of disinterested attitude of developers and lenders to architectural monuments, their condition has greatly deteriorated. Many buildings need not just cosmetic repairs, but serious restoration work. Revitalization projects of objects in the historical part of cities must be carried out on the basis of security documentation, which clearly regulates the approaches and principles of building reproduction. Such projects should also be implemented on the basis of an integrated approach to the reproduction of buildings, which will make it possible to ensure the maximum preservation of their valuable historical environment and compliance with monument protection requirements.

Since the planning structure and construction of old quarters were created in accordance with the requirements of previous socio-economic eras, they are practically not amenable to adaptation to new functions. Therefore, today the task is to carry out their reconstruction with the maximum preservation of historically valuable buildings and at the same time harmoniously fit new structural elements into their subject-spatial environment. Here, it is important to ensure that when a new building is introduced into the historical environment, the modern architectural form becomes part of the formed architectural ensemble, and does not look like a foreign element. It is necessary to treat the historically valuable buildings with great responsibility, which must be preserved and maintained in good condition in every possible way, at the same time not to refuse the construction of new buildings in the historical environment, which should correspond in appearance and technology to the present, and not mechanically copy the historical past, devaluing it.
PREREQUISITES FOR THE CREATION OF ETHNOGRAPHIC PARK "SHKODOVA MOUNTAIN" IN ODESSA
Authors: Ovsiankin Oleksandr , Storozhuk Svitlana
Published: September 2023

The article examines ethnographic parks, open-air museums and cave settlements of Ukraine for the relevance of creating an ethnographic park in Odessa.

Tourist centers of territorial tourism systems are, as a rule, historical settlements that have valuable objects of cultural heritage and are determined according to the List of Historical Settlements of Ukraine. The role of tourist centers, in addition to historical settlements, is played by almost all regional cities, which, in addition to monuments, also have notable objects of modern architecture. Most ethnographic parks and open-air museums are located in the northwestern part of Ukraine. One of the most famous open-air museums of our country is the National Museum of Folk Architecture and Life of Ukraine, better known as the Pirogov Museum, which is located in the village of Pirogov, Kyiv region. The open-air Ethnographic Museum "Frumushyka-Nova Bessarabian Village" (2008) has only recently appeared in Odessa region. Another interesting type of settlement found on the territory of our country is Cave settlements (fortresses, cities and monasteries), the most famous "Cave Cities" are located in Crimea. On the mainland of Ukraine, cave settlements are mainly represented by "Cave monasteries". Odessa "Shkodova Mountain" is the center of Usativ culture, on the top of the mountain there is the Usativ cemetery and the Usativ burial mound, at the foot of it – another Cossack cemetery and the famous "Cave Houses" – unique historical monuments of the end of the 18th century, which need to be preserved as a unique cultural heritage of the Cossack era in Odessa. This territory, with appropriate natural and landscape resources within the settlement, which has a natural landscape, historical monuments, a beach and bathing area (a good location on the shore of the Khadzhibey estuary) and the presence of recreational facilities (Sanatorium "Kuyalnik"), can become a wonderful a short-term recreation area for tourists and residents of Odessa.

All this indicates the urgency of creating an ethnographic museum in the city of Odessa called "Shkodova Mountain", taking into account the historical and archaeological value of this territory.
LEADING TRENDS OF FORMATION ENVIRONMENTAL DESIGN INTERIORS MODERN TRADE AND ENTERTAINMENT COMPLEXES
Authors: Osadchaya Marta , Zaporozhchenko Oksana
Published: September 2023

The environmental trends of interior design of modern shopping and entertainment centers are highlighted. The ways of solving modern problems of forming the architecture of internal spaces of this type of structures with the help of ecological design are determined. This requires: forecasting the "life" of the object at all stages – from construction to disposal using the latest technologies and energy saving, saving natural resources and energy, the use of waste-free technologies and eco-materials, ensuring a comfortable microclimate and environmental waste disposal. Thanks to the use of eco-trends in the interior design of shopping and entertainment complexes, the creation of a compositionally unified, balanced, harmoniously holistic, artistic and expressive interior space is achieved, which also meets the complex of utilitarian and functional, ergonomic, structural, economic and technological requirements. Environmental design of interiors is a leading trend in the design of modern interiors of shopping and entertainment complexes, since its objects provide a comfortable physiological and psychological state of visitors, form a respect for natural resources and taste preferences of people, their consumer attitudes, worldview and aesthetic ideals, that is, ecological culture population. The ecological design of the interiors of shopping and entertainment centers is an important competitive advantage, affects their attendance, makes it possible to get new tenants, attract more visitors and, as a result, increase income. The use of modern eco-trends in the design of the interiors of buildings of this type allows modern architects to obtain fresh solutions and creative approaches to solving design problems that can satisfy the needs of even the most demanding customers of modern shopping and entertainment complexes.
GLOBAL TRENDS IN THE CREATION OF THEME ENTERTAINMENT SPOTS
Authors: Pishchev David , Urenov Valerii
Published: September 2023

Entertainment is one of the most important areas of people’s social practices, which significantly affects the state of society. Satisfaction with the quality and availability for the society is the development quotient of the country’s economy and its social sphere. In fact the formation of the entertainment industry is a direct consequence to reach a certain level of population income, when there is available cash. The practice of creating special conditions for the organization of entertainment processes led to the introduction of a potential entertainment industry, which has developed by the end of the 20th century. The article provides an overview of modern world trends in the design of theme recreational facilities based on the analysis of foreign and local experience. Their features and techniques used in creating a theme space are revealed. There are the examples of the most famous and iconic theme recreational facilities.

The research purpose is to conduct the analysis of the existing theme recreational facilities and provide the recommendations for the designers. The presence of a theme leisure facility contributes to the development of the city and the region in general, they contain a whole infrastructure for receiving and serving the visitors. A theme recreational facility is a separate entertainment object created for the commercial purposes based on a popular theme (from literature, history, cinema, music, etc.), which is the tool for selecting and mythologizing space, is used in the elements of environmental design, complex symbolism, attractions etc. The analysis of the research work showed that the subject of the structure can be determined by the places associated with historical events, natural objects and conservation area, buildings and structures, memorial monuments, the works of architecture and urban planning, original engineering structures, objects, related to the life and activities of people, technical exhibits, art monuments, archaeological monuments, folk custom, modern or future achievements, etc. In order to unite people of different ages, the adult population are involved as the organizers of a short family trip, the main theme of the park is not only entertaining, but also informative.

The scientific novelty of the research is in the fact that the regularity and possibility of applying this method allows to get a working tool that will help to design theme entertainment complexes.
Psycho-Social Factors as Elixir to the School Adjustment of High Ability Secondary School Students in Oyo State, Nigeria
Authors: Salako Adebayo Adeyinka
Published: September 2023

This study was carried out to investigate psycho-social factors (peer-attachment, emotional intelligence, self-efficacy, and parental involvement) as an elixir for the school adjustment of high-ability secondary school students (HASSS) in Oyo State, Nigeria. The population for this study comprised all high-ability senior secondary schools in Oyo State. A multi-stage sampling procedure was used. The Slosson Intelligence test (r = 0.86) was employed, and students with an IQ level of 120-129 were purposively selected for this study. English Language (r = 0.75) and Mathematics Achievement (r = 0.72) tests, Peer-attachment (r = 0.74), Parental Involvement (r = 0.81), and School Adjustment (r = 0.84) questionnaires, Emotional Intelligence (r = 0.78), and Self-efficacy (r = 0.72) scales were the main instruments used for data collection. Data were analysed using multiple regression at the 0.05 level of significance. Peer-attachment (r = 0.88), emotional intelligence (r = 0.99), self-efficacy (r = 0.98), and parental involvement (r = 0.97) had a joint and relative contribution to the school adjustment of HASSS (F(4;445) = 23652.96; Adj R2 = 0.875), which accounted for 99.5% of its variance. Emotional intelligence (β = 0.83), self-efficacy (β = 0.37), peer-attachment (β = 0.04), and parental involvement (β = -0.23) made significant relative contributions to the school adjustment of HASSS. Therefore, relevant government bodies and schools should adopt strategies that can positively trigger the positive aspects of these variables for exploitation in influencing school adjustment among students.
Problematika Investor State Dispute Settlement dalam Bilateral Investment Treaty Indonesia-Singapura 2018
Authors: Zulkarnain Mukhamad
Published: September 2023

The signing of the 2018 Indonesia-Singapore BIT is a new chapter for Indonesia in establishing international relations in the field of investment after in 2013 Indonesia stopped the 2005 Indonesia-Singapore BIT because it was more in favor of foreign investors. This alignment is contained in the Investor State Dispute Settlement (ISDS) mechanism where the dispute resolution mechanism is also regulated in the 2018 Indonesia-Singapore BIT even though it is known that the ISDS mechanism has many shortcomings and provides protection for foreign investors. Therefore, there is a need for a new alternative to perfect the ISDS mechanism. Normative juridical methods are used in this writing by qualitatively analyzing the data.  The results of the study concluded that the ISDS mechanism in the Indonesia-Singapore BIT 2018 has not been able to protect Indonesia's interests in international investment cooperation and requires an Investment Court System (ICS) mechanism to perfect the ISDS mechanism.
The Big Five Personality Traits and Shopping Addiction among Young Turkish Adults
Authors: Alkan Neşe
Published: September 2023

With the onset of the COVID-19 pandemic and related restrictions, online shopping has become a part of the daily life of individuals across the globe. Shopping addiction or compulsive buying, on the other hand, is considered to be a growing behavioral addiction problem which renders individuals’ wellbeing and happiness. The current study aimed at examining the role of gender and the Big Five personality traits on shopping addiction among university students. Study data were obtained through an online survey platform. Seventy university students aged between 18 and 33 (M=23.10, SD=3.38) were included in the analyses. Group comparisons were carried out by conducting One-way Analysis of Variance. A hierarchical multiple regression analysis was used to test the hypothesized model where the shopping addiction score was the dependent variable. The predictor variables were extraversion, agreeableness, conscientiousness, neuroticism, and openness to experience scores of the participants. One-way Analysis of Variance tests results indicated a gender difference, with females scoring higher on the shopping addiction score. Hierarchical multiple regression analysis showed that only the openness to experience trait significantly and inversely predicted the shopping addiction. Empirical studies that address the relationship between potentially addictive shopping and the Big Five personality traits are producing inconclusive results. This study was specifically designed to examine the personality – shopping addiction relationship and supports the existing body of knowledge by providing findings from a non-Western culture. A possible protective role of openness to experience trait with regards to shopping addiction is the main implication of the study
CREB1 spatio-temporal dynamics within the rat pineal gland
Authors: Farias Altamirano Luz E . , Vásquez Elena , Freites Carlos L. , Ibañez Jorge E. , Guido Mario E . , Muñoz Estela M .
Published: September 2023

In the rat pineal gland (PG), cyclic AMP responsive element-binding protein 1 (CREB1) participates in the nocturnal melatonin synthesis that rhythmically modulates physiology and behavior. Phosphorylation of CREB1 is one of the key regulatory steps that drives pineal transcription. The spatio-temporal dynamics of CREB1 itself in the different PG cell types have not yet been documented. In this study we analyzed total CREB1 in the rat PG via Western blot and fluorescence immunohistochemistry followed by confocal laser-scanning microscopy and quantitative analysis. Total CREB1 levels remained constant in the PG throughout the light:dark cycle. The distribution pattern of nuclear CREB1 did vary among PG cell types. Pinealocytes emerged  to  have  discrete CREB1 domains within their nucleoplasm that were especially distinct. The number, size, and location of CREB1 foci fluctuated among pinealocytes, within the same PG and among Zeitgeber times (ZTs). A significantly larger dispersion of CREB1-immunoreactive nuclear sites was found at night than during the day. However, the overall transcription activity was mostly conserved between the light and dark phases, as shown by the expression of a particular phosphorylated form of the RNA polymerase II (RNAPII-pSer5CTD). Suppression of the nocturnal norepinephrine pulse by chronic bilateral superior cervical ganglionectomy increased CREB1 dispersion in pinealocyte nuclei at early night, as compared to sham-derived cells. In addition, differences in CREB1 distribution were found between sham-operated and non-operated rats at ZT14. Together, these data suggest that in mature pinealocytes, nuclear CREB1 is subjected to a dynamic spatio-temporal distribution. Further studies are necessary to elucidate the underlying mechanisms and to understand the impact of CREB1 reorganization in the pineal transcriptome.
Hacia un mix energético descarbonizado: beneficios, desafíos y oportunidades de la reforma del mercado eléctrico
Authors: Collado Van-Baumberghen Natalia
Published: September 2023

Las debilidades detectadas en el mercado eléctrico y cómo subsanarlas han sido objeto de estudio en la literatura académica desde hace años. Sin embargo, no ha sido hasta la actual crisis energética cuando ha habido interés político en emprender una reforma. En este artículo se analiza por qué ha sido así y cómo el debate actual está fuertemente ligado a los intereses nacionales sobre el rumbo de la política energética e industrial europea, lo que va a condicionar su resultado.
La dimensión social de la transición energética
Authors: Martín Murillo Laura , Sánchez López Ana Belén
Published: September 2023

Avanzar en una transición energética ágil es un imperativo de la lucha contra el cambio climático. Hasta el momento, el análisis de las dimensiones tecnológicas y económicas de la transición han centrado la mayor parte de los debates, estudios e investigaciones. El objetivo del artículo es arrojar luz sobre la dimensión social de este cambio, aún poco analizada. Abordar adecuadamente los impactos sociales es fundamental para no agravar los problemas de pobreza o desigualdad derivados del propio cambio climático y de las políticas implementadas para solucionarlo.
ROLE OF SUCTION/INJECTION ON MIXED CONVECTION FLOW IN A VERTICAL MICROCHANNEL FILLED WITH POROUS MATERIAL
Authors: Daramola Deborah A. , Ajibade Abiodun O. , Lawal Hammed. A.
Published: September 2023

A suction/injection controlled mixed convection flow of an incompressible and viscous fluid in a vertical microchannel filled with porous material with asymmetric plate temperature is presented. The governing equations are derived and solved using the method of undetermined coefficient. The closed form expression for temperature field, velocity field, skin friction and Nusselt number for the steady fully developed flow are obtained analytically. The effects of the governing parameters on the microchannel hydrodynamic and thermal behaviors are determined. It is interesting to point out that growing the Darcy number as well as the suction S accelerate the fluid motion while they reduce the critical values of the  ( at which flow reversal sets in ) on both plates. The stability of the flow is affected by variation in the permeability of the porous material.
BEL RUMAH MENGGUNAKAN SENSOR ULTRASONIK DENGAN NOTIFIKASI BOT TELEGRAM
Authors: R Khoirul , K Fransiska L , A Alfin E. , Noprianto Noprianto
Published: September 2023

Bel rumah merupakan sebuah perangkat yang berfungsi sebagai pemberitahuan kepada pemilik rumah bahwa ada orang yang berada di depan pintu. Akan tetapi, bel rumah konvensional kurang efektif karena terbatasnya jangkauan suara yang dihasilkan oleh bel. Dengan permasalahan tersebut menghadirkan solusi penggunaan sensor ultrasonik yang dapat mengirimkan notifikasi menggunakan bot Telegram. Penggunaan sensor ultrasonik dapat menjadi alternatif pengganti saklar bel. Untuk menyambungkan ke dashboard dan ke bot Telegram menggunakan aplikasi Node Red. Artikel ini membahas tentang pengembangan sistem pemantuan bel rumah menggunakan sensor ultrasonik selanjutnya mengirimkan notifikasi melalui bot yang terdapat pada aplikasi Telegram. Sistem ini dirancang untuk membantu mempermudah proses pemantauan bel rumah tanpa harus menekan bel. Sensor ultrasonik digunakan untuk mendeteksi adanya objek yang ada di depan pintu, jika terdapat objek di depan pintu maka sensor mengirimkan sinyal ke microcontroller untuk memproses informasi. Kemudian microcontroller akan mengirimkan notifikasi melalui Bot Telegram ke pemilik rumah untuk memberikan informasi bahwa ada tamu yang datang. Serta megirimkan data ke aplikasi Node Red sehingga bisa disajikan pada dashboard. Dengan menggunakan sistem ini, pemilik rumah dapat memantau bel rumah dengan mudah dan efisien tanpa harus menekan bel jika ada seorang tamu. Kesimpulannya, sistem pemantauan bel rumah menggunakan sensor ultrasonic dan notifikasi melalui aplikasi Telegram merupakan solusi yang efisien dan mudah untuk mempermudah proses pemantauan bel rumah.
Afterword: On Ethics, Cultural Capital and Sustainability
Authors: Bonnie Rick , Lorenzon Marta , Thomas Suzie
Published: September 2023

In this concluding chapter the editors provide commentary and response in relation to the previous chapters. We identify commonly emerging themes, namely ethics, cultural capital and sustainability, and draw out connections between the cases as revealed by the book’s authors. We conclude by thanking the contributors to the volume once more.
A New Approach to Community Archaeology in the Israel Antiquities Authority: A View from the Northern Region
Authors: Ambar-Armon Einat
Published: September 2023

The Israel Antiquities Authority (IAA) is in charge of the country’s antiquities and antiquity sites and their excavation, preservation, study and publication, as well as bringing the community closer to the long and rich legacy of the Land of Israel. This chapter focuses on some of the new projects in the northern region of Israel that have taken place over the past few years, since the IAA developed and enhanced its educational and community commitments. The activities are targeted at the entire population and are intended to initiate widespread exposure to archaeology. Activities take place all over Israel, designed for all ages as well as for all sectors and religions. The entire community is invited to take part in archaeological excavations and in a variety of educational initiatives. At the same time, the public is invited to see the backstage of the excavations, to see discoveries revealed to them as soon as they are found, and to access the findings through displays located near local sites and communities. The main purpose of these projects is to set the scene for community exposure to archaeology and create a meaningful, valuable and exciting experience that will eventually allow the public to become acquainted with the legacy and involved in preserving archaeological finds and ancient sites.
Stres Kerja Dalam Kepuasan Kerja (Studi Kasus Pada Bagian Rekam Medik RS Immanuel Bandung)
Authors: Sonjaya Yana , Nopianti Delia
Published: September 2023

Penelitian ini bertujuan untuk mengetahui gambaran menenai stres kerja, kepuasan kerja karyawan serta menguji pengaruh stres kerja terhadap kepuasan kerja karyawan pada bagian Rekam Medik di Rumah Sakit Immanuel Bandung. Metode yang digunakan dalam penelitian ini adalah metode survei. Jumlah karyawan Rekam Medik berjumlah 42 orang dengan teknik penarikan sampel menggunakan Non-Probability Sampling sehingga seluruh karyawan diikutsertakan dalam penelitian ini. Hasil penelitian menunjukkan gambaran mengenai stres kerja sebesar 41.97% yang berarti tergolong cukup, gambaran mengenai kepuasan kerja sebesar 65% yang berarti tergolong tinggi. Pengaruh stres kerja terhadap kepuasan kerja karyawan bagian Rekam Medik di Rumah Sakit Immanuel Bandung mempunyai hubungan yang negatif dan tidak signifikan, sehingga semakin tinggi tingkat stres kerja maka kepuasan kerja karyawan akan menurun.
Kompensasi Dalam Kinerja Tenaga Kependidikan Honorer Di Sekolah Menengah Pertama Negeri (SMPN) 2 Arjasari Kabupaten Bandung
Authors: Setiyani Wajar , Yanti Neng
Published: September 2023

Penelitian ini merupakan penelitian kuantitatif, artinya penelitian yang berpusat atau menghasilkan angka-angka (data dekriptif). Jenis pengumpulan data dalam penelitian ini adalah dengan melakukan penelitian lapangan (field research) yaitu penelitian yang dilakukan dengan pengumpulan data dan informasi yang diperoleh langsung dari responden dan mengamati secara langsung. Penulis ingin mengetahui Variabel Independen (X): Kompensasi Variabel Dependen (Y): Kinerja Jika kompensasi kerja terpenuhi, maka kinerja tenaga kependidikan akan baik. Jika kompensasi kerja tidak terpenuhi, maka kinerja tenaga kependidikan akan kurang baik. Dan akan di dapat hipotesis Ada pengaruh yang signifikan antara kompensasi terhadap kinerja tenaga kependidikan honorer di SMPN 2 Arjasari atau Tidak ada pengaruh yang signifikan antara kompensasi terhadap kinerja tenaga kependidikan honorer di SMPN 2 Arjasari.
Okul Öncesi Öğretmenlerinin Akran Zorbalığına İlişkin Görüşlerinin İncelenmesi
Authors: Özgöker Sevim , Gürşimşek Ayşe Işık
Published: September 2023

Akran zorbalığı, akran ilişkilerinde yaygın olarak görülüyor olmasına karşın uzunca bir süre büyümenin doğası olarak kabul edilmiştir. Arkadaşlık ilişkilerinin oluşumunda ve çocuğun benlik algısının gelişiminde önemli bir dönem olması nedeniyle, okul öncesi dönemde çocuklarda zorbalık davranışlarının incelenmesi büyük önem taşımaktadır. Bu çalışma; okul öncesi öğretmenlerinin akran zorbalığına ilişkin görüşlerini belirlemek amacıyla yapılmıştır. Araştırmada yarı yapılandırılmış görüşme formu, nitel araştırma desenlerinden “durum çalışması” ve nitel veri toplama yöntemlerinden görüşme tekniği uygulanmıştır. Çalışmanın verileri Kuzey Kıbrıs Türk Cumhuriyeti’nde resmi ve özel 19 kurumda görev yapan 63 okul öncesi öğretmeninden toplanmıştır. Görüşmelerde elde edilen veriler içerik analizi yöntemi ile çözümlenmiştir. Araştırmanın sonucunda, öğretmenlerin sınıflarında en çok fiziksel zorbalık, en az ise sözel zorbalık türü ile karşılaştıkları görülmüştür. Öğretmenlerin büyük bir çoğunluğunun, zorbalık davranışları ile baş etme konusunda herhangi bir eğitim almadıklarını ifade etmeleri dikkat çeken bulgular arasındadır. Ayrıca öğretmenlerinin zorbalık davranışlarını önleme konusunda çoğunlukla “konuşma, empati kurma” ve “ödül-ceza” yöntemleri kullandıkları görülmüştür.
Merdeka Curriculum Better than K13 Curriculum?
Authors: Kamiliyah Zahirotul , Faruk Roizatul
Published: September 2023

The latest textbooks from the Merdeka curriculum are only available for the first year, namely 2022 for the first level. However, many people still doubt its effectiveness because the Merdeka curriculum is still in the socialization period. This study wants to dig deeper into the latest curriculum textbooks compared to the previous curriculum. This study was conducted using the comparative method of primary data. The K13 and the Merdeka Curriculum Textbooks were analyzed using textbook standards from the BSNP, which consisted of 4 aspects: Material Content, Material Presentation, Language, and Graphical elements. Then, do the scoring to measure suitability. The study results show that the Merdeka Curriculum textbooks get a higher score than the K13 textbooks as a whole and in every assessment aspect
PEMANFAATAN LIMBAH BUAH SEBAGAI PEMBUATAN PUPUK ORGANIK CAIR DALAM UPAYA PEMBERDAYAAN EKONOMI MASYARAKAT KELURAHAN KAMPUNG PENSIUNAN PADA MASA PANDEMI COVID-19
Authors: Pasaribu Anida , Fransiska Herlin
Published: September 2023

Limbah buah yang tertumpuk di sekitar lingkungan RT.02 RW.01 Kelurahan Kampung Pensiunan, Kecamatan Kepahiang, belum dimanfaatkan dengan baik oleh masyarakat sekitar. Berlebihnya volume limbah buah tersebut berasal dari penjualan masyarakat sekitar yang bekerja sebagai pedagang buah maupun dari limbah buah rumah tangga. Limbah buah yang dibuang tanpa dilakukan pengolahan memiliki dampak yang tidak baik bagi lingkungan. Oleh karena itu perlu dilakukan suatu kegiatan yang memanfaatkan potensi dari limbah buah ini yaitu dengan membuat pupuk organic cair dimana pembuatan pupuk organic cair limbah buah ini dapat dilakukan sendiri di rumah. Tujuan dari kegiatan ini adalah untuk mengurangi pencemaran lingkungan yang diakibatkan oleh limbah buah yang menumpuk dan terutama dapat membangun daya masyarakat dalam perekonomian pada masa pandemi covid-19. Metode yang digunakan adalah metode ceramah dan fermentasi. Pembuatan pupuk organic cair memerlukan proses fermentasi dengan waktu kurang lebih 10 hari dengan tambahan bahan lain yaitu air, gula merah, yakult, dan air cucian beras. Cara penggunaan pupuk organic cair limbah buah ini sangat mudah dan untuk penyemprotan pupuk organic cair limbah buah ini sebaiknya dengan interval waktu satu minggu jika musim kering atau 3 hari sekali pada musim hujan. Setelah proses pembuatan pupuk organic cair limbah buah selesai, maka perlu dilakukan pengemasan. Dengan membuat kemasan yang menarik, pupuk organic cair limbah buah akan memiliki nilai ekonomi sehingga dapat dijual baik secara offline dan online. Setelah proses pembuatan dan pengemasan pupuk organic limbah buah selesai maka akan dihasilkan produk berupa pupuk organic cair limbah buah. Produk tersebut dibagikan ke masyarakat sekitar dengan memberikan penjelasan cara pembuatan, cara penggunaan, manfaat, serta cara pemasaran pupuk organic cair limbah buah. Berdasarkan kegiatan yang dilakukan maka dapat diambil kesimpulan bahwa pemanfaatan limbah buah sebagai pembuatan pupuk organic cair memiliki peluang yang besar untuk meningkatkan ekonomi masyarakat terlebih pada masa pandemic covid-19 dan memberikan dampak yang baik bagi lingkungan.
PEMANFAATAN LIMBAH PLASTIK MENJADI PRODUK KREATIF SEBAGAI MEDIA PEMBELAJARAN BAGI PELAJAR DESA TERUSAN MULYA, KABUPATEN KAPUAS, KALIMANTAN TENGAH
Authors: Wibowo Dimas Mulianto , Sari Julia Purnama
Published: September 2023

Semakin meningkatnya sampah di Desa Terusan Mulya ini akan menjadi masalah serius apabila tidak dicari penyelesaiannya. Di satu sisi penemuan plastik ini mempunyai dampak positif yang luar biasa, karena plastik memiliki keunggulan-keunggulan dibanding material lain. Berdasarkan analisis tersebut maka kegiatan pengabdian masyarakat ini perlu dilakukan dengan tujuan dapat meningkatkan kesadaran bagi para pelajar untuk peduli menjaga lingkungannya. Khususnya, mengelola limbah plastik menjadi produk kreatif atau kerajinan tangan yang dapat mengembangkan kreativitas serta rasa ingin tahu para pelajar.Berdasarkan hasil evaluasi diketahui, beberapa manfaat praktis yang diperoleh oleh para pelajar di Desa Terusan Mulya, yaitu: Para siswa/i mendapatkan informasi yang jelas dan utuh mengenai hakikat pemberdayaan masyarakat dari segi pengetahuan dan keterampilan; Para siswa/i yang menjadi peserta pelatihan memperoleh gambaran yang jelas mengenai potensi langkah pembuatan produk kreatif dengan memanfaatkan limbah sampah plastik sekali pakai untuk dapat dijual, sehingga bernilai ekonomis; Peserta pelatihan juga mendapatkan gambaran yang jelas dan utuh tentang manfaat limbah jika dikelola dengan baik.
Kata Kunci: Limbah Plastik, Produk Kreatif, Media Pembelajaran, terusan Mulya
 
ABSTRACT
 THE USE OF PLASTIC WASTE INTO CREATIVE PRODUCTS AS A LEARNING MEDIA FOR STUDENTS IN TERUSAN VILLAGE, KAPUAS DISTRICT, CENTRAL KALIMANTAN. The increasing waste in the village of Terusan Mulya will become a serious problem if a solution is not sought. On the other hand, the discovery of plastic has had a tremendous positive impact, because plastic has advantages over other materials. Based on this analysis, this community service activity needs to be carried out with the aim of increasing awareness for students to care about protecting their environment. In particular, managing plastic waste into creative products or handicrafts can develop the creativity and curiosity of students. Based on the results of the evaluation, it is known that students in the Terusan Mulya Village have received several practical benefits, namely: Students get information clear and a complete understanding of the nature of community empowerment in terms of knowledge and skills; The students who become training participants get a clear picture of the potential steps for making creative products by utilizing single-use plastic waste to be sold, so it has economic value; Training participants also get a clear and complete picture of the benefits of waste if it is managed properly.
 Keywords: Plastic Waste, Product Creative, Learning Media, Terusan Village
EKSPLORASI KECERDASAN BERHITUNG ANAK DENGAN PEMBELAJARAN TERBIMBING MELALUI PERMAINAN ABAKUS
Authors: Suratmin Idam Abdurrohim Hasani , Helmiyetti
Published: September 2023

Anak adalah aset generasi bangsa. Di tangan merekalah  estafet kehidupan dari generasi terdahulu akan diserahkan. Mendapat pendidikan yang layak adalah hak setiap anak. Namun banyak faktor yang mempengaruhi kualitas belajar anak. Pendidikan adalah salah satu upaya untuk mencerdaskan kehidupan bangsa. Sedangkan perlindungan anak merupakan suatu upaya untuk menciptakan kondisi dimana anak dapat melaksanakan hak dan kewajibanya. Berdasarkan hasil observasi yang telah dilakukan pada tanggal 03 s.d 12 Maret 2023 didapatkan hasil bahwa terdapat anak dengan inisialnya adalah RF yang tinggal di RT 13 memiliki keinginan belajar yang tinggi, terkhusus dalam bidang matematika. Namun antusias yang tinggi yang tidak didukung dengan lingkungan keluarga yang mendukung membuat anak tidak dapat mengembangkan pola belajar mereka terkait mata pelajaran matematika tersebut. Hal ini berakibat pada kemampuan anak dalam berhitung yang sangat buruk dan berdampak pada pendidikan anak tersebut di sekolah yang harus tidak naik kelas. Selain itu, permasalahan lain yang ditemui pada RF ialah kemampuan anak dalam mengutarakan pendapat di depan umum sangat kurang. Maka dari pelaksanaan Kuliah Kerja Nyata (KKN) kemudian menjadi suatu kesempatan untuk pengabdian dengan program mengadakan pendampingan belajar berhitung untuk mengeksplorasi kecerdasan RF dengan menggunakan media abakus. Hasil pendampingan diperoleh kemajuan kemampuan anak dalam memahami konsep perhitungan dasar (Penjumlahan, Pengurangan, Perkalian, dan Pembagian). Selain itu, kemampuan anak dalam berbicara di depan umum lebih terlihat dan anak lebih riang dari sebelum terjalannya program.