bluuebunny/crossref_metadata_2025 huggingface dataset:
Time To Recovery And Its Predictors Among Severe Community Acquired Pneumonia Patients Admitted To Pediatric Ward, Debre-markos Referral Hospital, North West Ethiopia, Retrospective Follow-up Study, 2019
Authors: Mitiku Belayneh Mengist
Published: August 2019

Background

- Globally, pneumonia is a major cause of morbidity and mortality among children which affects 151.8 million each year. It leads over 156 million episodes and 14.9 million hospitalizations per year. Besides this fact, the recovery time and predictors of children’s hospitalization related to severe community acquired pneumonia is not well known.

Objective

-The aim of this study was to estimate the median time to recovery and its predictors among severe community acquired pneumonia patients admitted to pediatric ward, Debre Markos Referral Hospital, North West Ethiopia.

Methods

- An institution based retrospective follow up study was employed among 352 records of children who were admitted starting from January 2016 to December, 2018. Patients chart were retrieved using a structured data extraction tool. Data was entered using Epi-Data version 3.02 and analyzed using STATA version 14 statistical software. The Kaplan Meier survival curve and log rank tests were used. Cox proportional hazard model assumption and model fitness were checked. Stratified Cox regression was fitted as a final model. Hazard ratio with its 95% confidence interval was used and P-value < 0.05 was considered as statistically significant association.

Result-

The overall median recovery time was 4 days IQR (3-7). Recovery rate from severe community acquired pneumonia was 16.25 (95% CI: 14.54–18.15) per 100 person day observation. Age (AHR; 0.94 95% CI (0.90-0.98)), being stunted (AHR; 0.62 95% CI (0.43-0.91)), presence of danger sign at admission (AHR; 0.61 95% CI ((0.40-0.94)), late presentation to seek care (AHR; 0.64 95% CI (0.47-0.88)) and co-morbidity (AHR; 0.45 95% CI ((0.45(0.35-0.58)) were significant predictors of recovery time.
Conclusion: The median recovery time from severe community acquired pneumonia was long. Measures to reduce recovery time should be strengthened.
Key words:-pediatrics, predictors, severe community acquired pneumonia and time to recovery.
CAIX is a predictor of pathological complete response and is associated with higher survival in locally advanced breast cancer submitted to neoadjuvant chemotherapy
Authors: Alves Wilson Eduardo Furlan Matos , Bonatelli Murilo , Dufloth Rozany , Kerr Lígia Maria , Carrara Guilherme Freire Angotti , Costa Ricardo Filipe Alves da , Scapulatempo-Neto Cristovam , Tiezzi Daniel , Vieira René Aloísio da Costa , Pinheiro Céline
Published: August 2019

Background

Locally advanced breast cancer often undergoes neoadjuvant chemotherapy (NAC), which allows in vivo evaluation of the therapeutic response. The determination of the pathological complete response (pCR) is one way to evaluate the response to neoadjuvant chemotherapy. However, the rate of pCR differs significantly between molecular subtypes and the cause is not yet determined. Recently, the metabolic reprogramming of cancer cells and its implications for tumor growth and dissemination has gained increasing prominence and could contribute to a better understanding of NAC. Thus, this study proposed to evaluate the expression of metabolism-related proteins and its association with pCR and survival rates.

Methods

The expression of monocarboxylate transporters 1 and 4 (MCT1 and MCT4, respectively), cluster of differentiation 147 (CD147), glucose transporter-1 (GLUT1) and carbonic anhydrase IX (CAIX) was analyzed in 196 locally advanced breast cancer samples prior to NAC. The results were associated with clinical-pathological characteristics, occurrence of pCR, disease-free survival (DFS), disease-specific survival (DSS) and overall survival (OS).

Results

The occurrence of pCR was higher in the group of patients whith tumors expressing GLUT1 and CAIX than in the group without expression (27.8% versus 13.1%, p = 0.030 and 46.2% versus 13.5%, p = 0.007, respectively). Together with regional lymph nodes staging and mitotic staging, CAIX expression was considered an independent predictor of pCR. In addition, CAIX expression was associated with DFS and DSS (p = 0.005 and p = 0.012, respectively).

Conclusions

CAIX expression was a predictor of pCR and was associated with higher DFS and DSS in locally advanced breast cancer patients subjected to NAC.
In silico prediction of structural and functional effects of the E71G mutation on GARS and its role in CMT2D and HMN5A pathogenesis
Authors: Garcia Ericka Mae , Mea Angelica , Frio Enrique Jose , Endriga Marla
Published: August 2019

Background The E71G mutation in GARS results in Charcot-Marie-Tooth disease type 2D (CMT2D) with overlapping distal hereditary motor neuropathy type 5A (HMN5A) phenotype, but the pathogenesis is unclear. This study aimed to predict the structural and functional effects of this mutation on GARS’ interaction with some of its putative or actual ligands in relation to CMT2D and HMN5A manifestation. Methods Putative or actual ligands of GARS were identified from 10 protein databases using Cytoscape 3.4.0. Thirty-one (31) ligands met our criteria and were selected for the study. GRAMM-X was utilized for docking simulations. The RMSD value difference between wild-type and docked ligands, change in binding free energy, and changes in interface between wild type and native GARS were analyzed. Results Our in silico analysis showed that GARS interaction with 19 distinct putative or actual ligands increased in stability, 10 decreased in stability, and two (2) were unchanged energetically. Data mining and network analysis showed that the ligands are involved in apoptosis, autophagy, and immune response, as well as the ubiquitin proteasome system and NGF/TrkA signaling. Conclusions These findings indicate that several biological processes (apoptosis, autophagy, and immune response) and pathways (ubiquitin proteasome system and NGF/TrkA signaling) may be affected by the E71G mutation. This suggests that GARS is a key molecule in CMT2D and HMN5A pathogenesis and shows promise as a target for novel drugs. Further experimentation is needed to verify these findings.
LncRNA and transcriptomic analysis of fetal membrane revealed potential targets involved in oligohydramnios
Authors: Ou Yu-hua , Liu Yu-kun , Zhu Li-qiong , Chen Man-qi , Yi Xiao-chun , Chen Hui , Zhang Jian-ping
Published: August 2019

The challenge of oligohydramnios study is multiple causes of oligohydramnios. Long noncoding RNAs (lncRNAs) is a set of RNAs that has been proved to function in multiple biological process. Currently, little is know about their expression and possible role in oligohydramnios. Total RNA was isolated from fetal membranes ressected from oligohydramnios pregnant women (OR) and normal amniotic fluid control (Normal).RNA-sequencing (RNA-seq) obtain that a total of 801 lncRNAs and 367 mRNAs were differentially expressed in OR. Of which, 638 lncRNAs and 189 mRNAs were upregulated, and 163 lncRNAs and 178 mRNAs were downregulated. Of these lncRNAs, 566 of them were intergenic lncRNA, 351 were intronic antisense lncRNA，and 300 natural antisense. The differentially expressed lncRNA were primary located in chromosome 2, 1 and 11. KEGG enrichment pathways revealed the differential expressed mRNAs were enriched in pathway in cancer, Ras signaling pathway, TNF signaling pathway, focal adhesion, and chemokine signaling pathway. The qRT-PCR result confirmed that LINC00515 and RP11-388P9.2 were upregulated in OR. Furthermore, the constructed lncRNA-miRNA-mRNA regulatory network revealed TNR, CFTR, ABCC2, ABCA12, and COL9A2 as the candidate targets of LINC00515 and RP11-388P9.2. A wide range of lncRNAs were alert in OR, in particularly, LINC00515 and RP11-388P9.2 were confirmed to be uprgulated in OR, and their predicted downstream targets were transport and tissue growth and development associated. Further study focused on the role of differential expressed lncRNAs such as LINC00515 and RP11-388P9.2 would provide more insight into the pathophysiology in OR.
Microbiological quality and safety of Ready- to- eat foods from restaurants and food establishments in Yirgalem town Southern, Ethiopia
Authors: Arficho Tsegaye Shamebo , Kebede Asefa Hamato
Published: August 2019

Background: Foodborne illnesses are considered as one of the most important public health problems particularly in developing countries like Ethiopia. This study aimed to determine the microbiological quality and safety of ready-to-eat foods in Yirgalem town, southern Ethiopia from November 2016 to August 2017. Methods: The collection of ready-to-eat food samples and laboratory-based microbiological analysis was used as the study design. A total of 160 food samples comprising of 40 ‘Injera firfir’, 40‘Bayeaynet’, 40 Vegetables and 40 Spaghetti were collected and analyzed for microbial contamination following standard microbiological methods. Ten grams of each food sample was transferred into 90 ml of buffered peptone water and homogenized for 5 minutes using a vortex mixer. The homogenates were serial diluted up to 10-7 and a volume of 0.1ml aliquot was spread plated on pre-solidified media of Aerobic plate count agar, MacConkey agar, Mannitol salt agar, and Salmonella-Shigella agar and incubate at 35-37oc for 24 hrs. Also, Potato Dextrose Agar was used for the isolation of fungi. Data were entered into Microsoft Excel and analyzed using SPSS version 20.0. Results: All the collected food samples were subjected to total aerobic mesophilic bacteria, Coliform bacteria, Enterobacteriaceae, Staphylococcal, Yeasts, and Molds counts. Accordingly, the mean counts expressed as log10 CFU/g of food for each group of the organism were 7.90 ± 0.71, 4.31±1.30, 4.32 ± 1.30, 6.70 ± 0.34 and 4.5 ± 1.01, respectively. The highest bacterial load 162(28.9%) was detected in ‘Injera firfir’ whereas the lowest 108(19.2%) case was investigated in Spaghettis. Regarding the food safety issue, the frequency of S. aureus, E. coli and Salmonella spp in the food samples were 54.4%, 43.8%, and 0.6%, respectively. Conclusion: The high microbial load and existence of foodborne pathogens in ready-to-eat foods in Yirgalem town, Southern Ethiopia is calling for the creation of awareness among restaurant and food establishment owners and food handlers concerning the hygienic practice.
Keyword: Microbial quality, Yirgalem town, Southern Ethiopia
Access to cataract services in selected rural communities in South Africa
Authors: Khoza Lunic Base , Nunu Wilfred Njabulo , Manganye Bumani Solomon , Mambanga Pfungwa , Tshivhase Shonisani , Murwira Tinotenda Success , Ramakuela Nditsheni , Ndou Nthomeni
Published: August 2019

Background Despite government efforts to improve access to health care services through the re-engineered Primary Health Care and National Health insurance platform, access still remain a challenge particularly in rural areas. The aim of this study was to analyse secondary data on cataract patients who were attended to in selected hospitals in rural Limpopo of South Africa. Methodology A cross section survey was conducted on 411 patient records from five selected hospitals in Vhembe district. A pre tested structured checklist was used to guide retrieval of variables from patient records. The collected data was entered into excel spreadsheet, cleaned and imported into Statistical Package for Social Sciences version 26 for analysis. Proportions of demographic characteristics were presented and these were cross tabulated with the outcome variable “success of operation” using Chi Squared tests. Results Findings point out that majority of patients who attended hospital for eye services were aged 65 years above and females (63%). There was no association between the tested demographic characteristics and the outcome variable. Most patients were diagnosed in the period 2015-2018 (60%). Over 90% of those that were operated had successful operations. Of the remaining 10% that had unsuccessful operations, 30% cited complications as being the reason why these operations were unsuccessful. Conclusions It is evident from the findings that cataract services offered in rural areas have low impact as they are not accessible to the patient. It is critical to have a worker retention strategy to retain experts.
Short-term Results Of Sclerotherapy With 3% Polidocanol Foam For Symptomatic Second- And Third-degree Haemorrhoidal Disease
Authors: Lobascio Pierluigi , Laforgia Rita , Novelli Eugenio Novelli , Perrone Fabrizio , Salvo Maria Di , Pezzolla Angela , Trompetto Mario , Gallo Gaetano
Published: August 2019

Background.Haemorrhoidal disease (HD) is defined as the symptomatic enlargement and/or distal displacement of anal cushions and is one of the most common proctological diseases. Sclerotherapy (ST) with 3% polidocanol foam induces an inflammatory reaction with sclerosis of the submucosal tissue and consequent suspension of the haemorrhoidal tissue. The aim of this study was to evaluate the short-term effectiveness and safety of ST with 3% polidocanol foam for the treatment of symptomatic second- and third-degree HD. Methods.A total of 66 patients with symptomatic second- and third-degree HD underwent a single ST session between March 2017 and July 2018. A visual analogue scale score was used to assess post-operative pain and patient satisfaction. The symptoms severity and anal continence were investigated through a self-reported questionnaire and Vaizey score, respectively, at baseline, at 4 weeks and after 1 year. Results. Fifty-seven out of 66 patients were male (86.3%), and the mean age was 52 (29-75; SD ± 12) years. The mean operative time was 4.5 (2-6; SD ± 1.23) minutes. No intraoperative complications and no drug-related side effects occurred. The overall success rate was 78.8% (52/66 patients) after a single ST session and 86% after two ST sessions (57/66 patients). The mean treatment effect, obtained comparing preoperative and T5 symptom scores in each patient, showed a mean change of 7.88 (p<0.001). All patients resumed their normal daily activities the day after the procedures. Conclusions.ST with 3% polidocanol foam is a safe, cost-effective and repeatable conservative treatment.
Building literacies in secondary school history: The specific contribution of academic writing support
Authors: Breeze Ruth , Gerns Jiménez-Villarejo Pilar
Published: August 2019

This paper considers the specific role and effect of academic writing support in a secondary school Content and Language Integrated Learning (CLIL) context. After discussing the potential place for academic writing support in the ongoing process of fostering disciplinary literacy, we report on an experimental study in which 45 Spanish secondary school students received a short academic writing module as part of their history course. The descriptions/explanations written in their post-tests were generally found to be more complete, with more explicit discourse markers and with better textual organization than the pre-tests. We discuss the implications of this for students’ progress towards disciplinary literacy.
Reseña: Rodrigo, Victoria (2019). La comprensión lectora en la enseñanza del español LE/L2: de la teoría a la práctica. Londres/Nueva York: Routledge.
Authors: Méndez Santos María del Carmen
Published: August 2019

La importancia que se le ha otorgado a las diferentes destrezas lingüísticas ha variado en función del enfoque metodológico predominante en cada época. En particular la comprensión lectora pasó de ser el centro de atención en modelos clásicos a ser poco tratada en otros más modernos. Esta reseña analiza la monografía de Victoria Rodrigo, que ha compilado un panorama completo y prolijo de todo conocimiento que cualquier persona dedicada a la docencia, investigación o creación de materiales didácticos debería poseer sobre la comprensión lectora, prestando particular atención a la enseñanza del español como segunda lengua o lengua extranjera.
Effect of Cover Crop Termination Timing on Pools and Fluxes of Inorganic Nitrogen in No‐Till Corn
Authors: Otte Briana , Mirsky Steven , Schomberg Harry , Davis Brian , Tully Katherine
Published: August 2019

Cover crops are increasingly used around the world to enhance N cycling and provide a suite of agroecosystem benefits. The N scavenging capacity of cover crops during winter months is well recognized. Our research characterized spring management effects (e.g., early vs. late termination) on cover crop biomass, decomposition and N release rates, inorganic soil N, soil water dynamics, and corn (Zea mays L.) performance. Cereal rye (Secale cereale L.) was established in Beltsville, MD, to evaluate three management scenarios: no cover crop; early termination (∼40 d before corn planting); late termination (∼7 d before corn planting). Cereal rye biomass was quantified before termination, and decomposition was tracked over a 24‐wk period to assess loss. Soil N content to 100 cm, soil volumetric water content, and corn performance were evaluated over the corn growing season. Low spring precipitation in 2016 led to similar amounts of cereal rye biomass for early and late termination; however, late‐terminated cereal rye had lower quality biomass (higher C/N) in both years, leading to slower decomposition and N release rates. Over the corn growing season, late‐terminated cereal rye consistently had smaller soil N pools, suggesting more efficient N cycling (better synchrony of N release from cover crop residues with corn N demand) than early‐terminated cover crops. Corn yields were smallest following late‐terminated cereal rye in 2016, but there was no difference in yields among cover crop treatments in 2017. Overall, we conclude that planting cereal rye cover crops and delaying termination until later in the season will help retain and efficiently cycle N while maintaining high corn yields.

Core Ideas

We tested the effect of cover crop termination timing on N dynamics before corn.

Late‐terminated cereal rye had slower rates of biomass loss and N release.

Larger soil N pools in 2017 than 2016 resulted from lower corn yields.

Cover crop biomass and corn performance were influenced by precipitation levels.

Nitrogen was more efficiently cycled in systems with cover crops than systems without cover crops.
Antimony(III/V) removal from industrial wastewaters: treatment of spent catalysts formally used in the SOHIO acrylonitrile process
Authors: Foster Richard I. , Oh Maeng-kyo , Yang Dasom , Shon Woo-Jung , Kim Kwang-Wook , Lee Keun-Young
Published: August 2019

A treatment and volume reduction process for a spent uranium–antimony catalyst has been developed. Targeted removal, immobilization and disposal of the uranium component has been confirmed, thus eliminating the radiological hazard. However, significant concentrations of antimony ([Sb] ≥ 25–50 mg L−1) remain in effluent from the process, which require removal in compliance with Korean wastewater regulations. Antimony(III/V) removal via co-precipitation with iron has been considered with optimal pH, dose and kinetics being determined. The effect of selected anions – Cl−, SO42− and PO43− – have also been considered, the latter present due to a prior uranium removal step. Removal of Sb(III) from both Cl− and SO42− media and Sb(V) removal from Cl− media to below release limits were found to be effective within 5 minutes at an iron dose of 8 mM (molar ratio, [FeIII]/[Sb] = 20) and a target pH of 5.0. However, Sb(V) removal from SO42− was significantly hampered requiring significantly higher iron dosages for the same removal performance. Phosphate poses significant challenges for the removal of Sb(V) due to competition between PO43− and Sb(OH)6− species for surface binding sites, attributed to similarities in chemistries and a shared preference for an inner vs outer binding mechanism.
Direito ao corpo e à vida: a invisibilidade do intersexo no campo social
Authors: COSTA Quézia Alexandre da , BERNARDES Anita Guazzelli , PALMIERE Júlia Arruda da Fonseca
Published: August 2019

Este texto tem como foco problematizar processos sociais e condições de acesso às possibilidades de vida pela população intersexual. Trata-se de um recorte de uma pesquisa que partiu do método cartográfico para pensar modalidades de subjetivação, assim, o percurso se deu por territórios virtuais, focalizando materiais encontrados nas mídias sociais sobre a população intersexual. Também foram percorridas políticas públicas sobre a temática. Os materiais foram analisados a partir de operadores conceituais de Michel Foucault: ética, verdade, biopolítica e governamentalidade. O percurso metodológico possibilitou pensar a composição de territórios existenciais e o modo como sujeitos se experimentam na relação com regimes de verdade sobre a intersexualidade. Este estudo permitiu considerar que umas das problemáticas fundamentais para a população intersexual, na atualidade, é a forma como é performada no campo social, pois, os regimes de verdades, pautados no binarismo de gênero contribuem para a invisibilidade das necessidades da população intersexo. A marginalização e estigma são condicionantes e determinantes de saúde que tem produzido formas de relação com esta experiência, fragilizando condições de vida. Portanto, entende-se que há necessidade de ações de promoção de saúde para esta população, com objetivo de oferecer maior visibilidade e espaços de discussão sobre a intersexualidade, considerando possibilidades de engendramento de regimes de verdade que operem na lógica da autonomia e inclusão social destes sujeitos.
Melatonin As a Modulator of Degenerative and Regenerative Signaling Pathways in Injured Retinal Ganglion Cells
Authors: Juybari Kobra B. , Hosseinzadeh Azam , Ghaznavi Habib , Kamali Mahboobeh , Sedaghat Ahad , Mehrzadi Saeed , Naseripour Masood
Published: August 2019

Optic neuropathies refer to the dysfunction or degeneration of optic nerve fibers caused by any reasons
including ischemia, inflammation, trauma, tumor, mitochondrial dysfunction, toxins, nutritional deficiency, inheritance,
etc. Post-mitotic CNS neurons, including retinal ganglion cells (RGCs) intrinsically have a limited
capacity for axon growth after either trauma or disease, leading to irreversible vision loss. In recent years, an
increasing number of laboratory evidence has evaluated optic nerve injuries, focusing on molecular signaling
pathways involved in RGC death. Trophic factor deprivation (TFD), inflammation, oxidative stress, mitochondrial
dysfunction, glutamate-induced excitotoxicity, ischemia, hypoxia, etc. have been recognized as important
molecular mechanisms leading to RGC apoptosis. Understanding these obstacles provides a better view to find
out new strategies against retinal cell damage. Melatonin, as a wide-spectrum antioxidant and powerful freeradical
scavenger, has the ability to protect RGCs or other cells against a variety of deleterious conditions such as
oxidative/nitrosative stress, hypoxia/ischemia, inflammatory processes, and apoptosis. In this review, we primarily
highlight the molecular regenerative and degenerative mechanisms involved in RGC survival/death and then
summarize the possible protective effects of melatonin in the process of RGC death in some ocular diseases including
optic neuropathies. Based on the information provided in this review, melatonin may act as a promising
agent to reduce RGC death in various retinal pathologic conditions.
Efficient Synthesis of Novel Quinolinone Derivatives via Catalyst-free Multicomponent Reaction
Authors: Du Rui , Han Liangliang , Zhou Zhongqiang , Borovkov Victor
Published: August 2019

The synthesis of 3-(aryl(piperidin-1-yl)methyl)-4-hydroxyquinolin-2(1H)-one derivatives
via catalyst-free multicomponent reaction is described. The reaction of 4-hydroxyquinolin-2(1H)-one,
piperidine, and 4-chlorobenzaldehyde was carried out in different solvents and under solvent-free conditions
at room temperature. The best solvent in terms of the yield and reaction time was found to be
dichloromethane. Most substituted benzaldehydes reacted with 4-hydroxyquinolin-2(1H)-one and
piperidine to afford corresponding products in good-to-excellent yields. Aldehydes with electronwithdrawing
groups were more reactive to exhibit higher reaction rates. However, 2-substituted benzaldehydes
did not react with 4-hydroxyquinolin-2(1H)-one and piperidine under the reaction condition.
Aldehydes bearing a hydroxyl group failed to produce the corresponding products.
Pathophysiology and Management of Atopic Dermatitis: A Laconic Review
Authors: Kumar Pravin , Sharma Dinesh Kumar , Ashawat Mahendra Singh
Published: August 2019

Conclusion:

Atopic Dermatitis (AD) is long-lasting degenerating skin disease with a characteristic phenotype and stereotypically spread skin lesions. The AD results due to a complex interface among genetic factors, host’s surroundings, pharmacological anomalies and immunological factors. In previous decades, researchers had shown marked interest due to increased prevalence in developed countries. In this review, basics along with the advances in pathogenesis and management of AD have been discussed. The immunological factors i.e. Innate Lymphoid Cells, IL-22 and Toll-like receptors have an important role in the pathogenesis. The proactive topical therapy by skincare, topical glucocorticosteroids and calcineurin inhibitors have improved effect in the management of AD. The human monoclonal antibody-based systemic drug (Duplimab) is a considerable advancement in the management of AD. Other monoclonal antibody-based drugs (Lebrikizumab, Tralokinumab, Apremilast and Nemolizumab) are in different phases of clinical trials. A better understanding of genetics and immunoregulatory cascade will lead to the development of efficacious drugs and better management therapy preventing the relapse of flares and improved life quality of AD patients.
Rare Earth Doped Hydroxyapatite Nanoparticles for In Vitro Bioimaging Applications
Authors: Zantye Pranjita , Fernandes Fiona , Ramanan Sutapa Roy , Kowshik Meenal
Published: August 2019

:

Fluorescence based bioimaging is one of the widely used method
for obtaining imperative information on life processes.

Objective:

Within the expansive spectrum of fluorescent agents being investigated, the trivalent
Lanthanide (Ln) ion based nanoparticles have attracted attention due to their intrinsic
luminescence property.

Methods:

Here we report a modified sol gel assisted synthesis of Europium (Eu) and Samarium
(Sm) doped Hydroxyapatite nanoparticles (HAp NPs). Doping Ln ions in the selffluorescent
hydroxyapatite lattice contributed towards an increased luminescence in the
NPs.

Results:

The XRD patterns reveal that the Eu+3 and Sm+3 doped HAp NPs display the
characteristic peaks of hydroxyapatite in a hexagonal lattice structure, and the FTIR data
confirms presence of characteristic functional groups. The as-synthesized HAp NPs exhibit
short rod-shaped morphology with average length less than 60 nm. Upon excitation at representative
wavelengths, the doped HAp NPs demonstrated characteristic emission lines of
Eu+3 and Sm+3.

Conclusion:

The as-synthesized NPs displayed no toxicity towards HeLa cells and are
easily internalized, exhibiting their potential as promising live cell bioimaging agents.
From “Step Away” to “Stand Down”: Tailoring a Smartphone App for Self-Management of Hazardous Drinking for Veterans (Preprint)
Authors: Blonigen Daniel , Harris-Olenak Brooke , Kuhn Eric , Humphreys Keith , Timko Christine , Dulin Patrick
Published: August 2019

BACKGROUND

US military veterans who screen positive for hazardous drinking during primary care visits may benefit from a mobile app. Step Away is an evidence-based mobile intervention system for the self-management of hazardous drinking. However, Step Away was not designed for veterans, and differences between veterans and civilians could limit the reach and effectiveness of the app with this population.

OBJECTIVE

The primary objective of this study was to repurpose Step Away to address the needs and preferences of the veteran primary care population. The Method for Program Adaptation through Community Engagement (M-PACE) model was used to guide the adaptation process. This model can serve as a generalizable approach that other researchers and intervention developers can follow to systematically tailor mobile health tools for a new population.

METHODS

Veteran patients who screened positive for hazardous drinking during a primary care visit (n=12) and peer providers employed by the US Veterans Health Administration (n=11) were recruited to systematically review Step Away and provide feedback on its content and presentation via Web-based surveys and a semistructured interview. Participant feedback was reviewed through an iterative process by key stakeholders who adjudicated which suggested modifications to the app could enhance engagement and effectiveness with veterans while maintaining program integrity.

RESULTS

Usability ratings of the individual modules of Step Away were uniformly positive across patients and peers, as was the perceived utility of the app overall. Personalized feedback on the health consequences and costs of drinking, options for customization, and the measurement-based care capabilities of the app were viewed as facilitators of engagement. Conversely, lengthy text, small font, and a lack of interactive features were viewed as potential barriers with the older primary care population. Modifications to create a veteran version of the app (Stand Down: Think Before You Drink) included altering the appearance of the app to incorporate more veteran-centric content, adding links and options for resources and activities for veterans, and reducing the amount of text and adding veteran-specific references and common concerns and triggers for drinking in this population.

CONCLUSIONS

The M-PACE model provided a systematic approach to repurpose Step Away to fit the needs and preferences of veteran primary care patients who engage in hazardous drinking. Stand Down may serve as an innovative, low-cost means of expanding access to care for veterans who engage in hazardous drinking.
SENDİKA TEMSİLCİLERİNİN LİDERLİK TUTUM VE DAVRANIŞLARININ SENDİKAL BAĞLILIK ÜZERİNE ETKİSİ SAKARYA İLİ ÖRNEĞİ
Authors: YILMAZ Tuncay , KİŞİOĞLU Hilal
Published: August 2019

Amaç:  Sakarya’da faaliyet gösteren kamu
eğitim kurumlarındaki iş yeri sendika temsilcilerinin liderlik davranış
özelliklerinin üyelerin sendikal bağlılıkları üzerindeki etkisinin
belirlenmesidir. Yöntem: Sakarya genelinde kamu kurumlarında görev yapan okul öncesi, ilkokul,
ortaokul ve lisede görevli Eğitim Bir-Sen, Türk Eğitim-Sen ve Eğitim-Sen
sendikalarına üye öğretmenler üzerinde bir araştırma yapılmıştır. Araştırmada veri
toplama aracı olarak araştırmanın amacı doğrultusunda hazırlanan anket formu
kullanılmış ve yüz yüze görüşme yoluyla 380 sendika üyesi öğretmene anket
uygulanmıştır.
Araştırma
sonucunda elde edilen verilerin analizinde SPSS 24.0 programı
kullanılmıştır.  Elde edilen veriler,
analiz edilirken frekans, ortalama, yüzde alma, faktör analizi, korelasyon ve
basit regresyon analiz yöntemleri kullanılmıştır.Bulgular: Araştırma
bulgularından hareketle işyeri sendika temsilcilerinin özellikleri şu
şekildedir: arkadaş canlısı, diğerlerinin fikir ve önerilerini dinleyen,  astlarına güvenen, karar alırken riske
girmekten kaçınmayan, her işi kendisi yapmaya çalışan, kimin neden sorumlu
olduğunu her zaman bilen, başkalarına görev ve sorumluluk vermekten kaçınmayan,
açık ve dürüst bir yöntemi olan, tutarlı, eleştirilere açık, yeni fikirleri
tartışmaktan hoşlanan, kurallara ve prensiplere uymaya önem veren, iyi
çalışmaları takdir eden, amaçları belirgin, yeni projeler üreten, uygulanmakta
olan planlar üzerinde çok titiz, astlarını savunan, yeniliklere açık,
çatışmaları ortadan kaldıracak olanaklar yaratan, astlarına adil davranan,
gerektiğinde çabuk karar alan, planları dikkatli yapan, karar verirken
astlarına söz hakkı veren, esnek ve değişime açık olmalarıdır.  İş yeri sendika temsilcilerinin bu liderlik
özelliklerinin üyelerin sendikal bağlılıkları üzerinde etkisi bulunmaktadır.

Sonuç: İşyeri
sendika temsilcilerinin liderlik davranış özelliklerinin üyelerin sendikal
bağlılıkları üzerinde etkisi olduğu ortaya çıkmıştır.
Public Transport Effectiveness in Brazzaville
Authors: Nzololo Moyo
Published: August 2019

This research paper has to be set in the framework of an important urban growth. Such urbanization goes along with urban spreading that generates an increase in both urban mobility needs and the use of public transport.The paper focuses on public transport effectiveness in Brazzaville, from the analysis of determinants linked to public transport’s generalized cost on the one hand, and to the nuisance effects of such public transport on another hand.
Capital Structure, Agency Cost and Corporate Governance: Theoretical Linkages under the Operational Framework of a Modern Company
Authors: Bragoudakis Zacharias
Published: August 2019

The purpose of this paper is to explain the interaction mechanism between the capital structure of a modern company, the implying agency cost that is raised when the company is expanding and the corporate governance system that should be implemented in order to achieve a smoothness of the implied internal friction. The corporate governance experience suggests that there is a lack of a systemic management at those problems. The above corporate problems reduce the maximization of the company value. It is argued that the failure to maximize the value of the company can be attributed to the endogenous weakness of corporate interconnection. This paper analyses the theory of corporate interconnection between its agents (shareholders, executive managers and bondholders), contributes to a better understanding of those issues and propose some ideas of addressing them though a systematical and analytical framework.
The Logical Path of Cultural Integration under the Background of Globalization ——Take “The Belt and Road Initiative” as an Example
Authors: Xiaoyu Luo
Published: August 2019

The theory of world history put forward by Marx and Engels clearly depicts that the trend of globalization is from the globalization characterized by colonialism to the economic globalization and finally to the overall globalization. The overall globalization mainly reflects the cultural conflicts and integration caused by the differences in modes and values among different cultures. The fundamental logical contradiction of cultural conflict lies in dualism of national culture and non-national culture. Therefore, the worldwide demand for “cultural integration” comes into being. The new cultural concept advocated by “The Belt And Road” initiative, based on Marx’s historical materialism, provides a new path for cultural conflicts and responds to the call for “cultural integration”.
TINGKAT KETERBACAAN SOAL WACANA UJIAN NASIONAL (UN) TINGKAT SMA MATA PELAJARAN BAHASA INDONESIA TAHUN PELAJARAN 2013/2014
Authors: Nuryani Nuryani
Published: August 2019

Penelitian ini mendeskripsikan tingkat keterbacaan soal wacana Ujian Nasional (UN) tingkat SMA mata pelajaran Bahasa Indonesia tahun pelajaran 2013/2014. Fokus dalam penelitian adalah melihat jumlah kata dan kalimat sebagai penyusun sebuah wacana. Metode yang digunakan dalam penelitian ini adalah metode deskriptif kualitatif. Objek penelitian ini adalah soal-soal wacana UN tingkat SMA mata pelajaran Bahasa Indonesia. Analisis data dalam penelitian ini menggunakan formula Grafik Fry. Hasil yang didapatkan dalam penelitian ini adalah tingkat keterbacaan wacana dalam soal UN masih rendah. Terdapat jenis wacana yang cukup sulit, yang sebenarnya sesuai untuk disajikan di tingkat universitas. Selain itu, terdapat jenis wacana yang cukup ringan, yang sebenarnya sesuai untuk digunakan di tingkat SD maupun SMP. Untuk mengantisipasi hal tersebut perlu dilakukan analisis yang mendalam terhadap soal-soal wacana yang akan dijadikan sebagai bahan ujian, sehingga akan didapatkan tingkat keterbacaan yang sesuai.
KOSAKATA SEHARI-HARI KELOMPOK TRANSEKSUAL DI KECAMATAN PAKIS KABUPATEN MALANG
Authors: Prasetya Teguh
Published: August 2019

Penelitian ini mendeskripsikan kosakata sehari-hari kelompok transeksual yang mempunyai karakter unik di Kecamatan Pakis Kabupaten Malang. Penelitian ini menggunakan pendekatan kualitatif. Metode yang digunakan adalah analisis deskriptif. Sumber data penelitian ini berupa informan kelompok sosial transeksual di Kecamatan Pakis Kabupaten Malang. Data dalam penelitian ini berupa rekaman komunikasi yang dilakukan terhadap informan (transeksual) di salon tempat mereka berkerja. Teknik pengumpulan data dalam penelitian ini adalah observasi, perekaman, catatan lapangan, dan wawancara. Analisis data menggunakan model Miles dan Huberman. Hasil penelitian menggambarkan wujud kosakata sehari-hari kelompok transeksual berupa tanda, kode, simbol, dan permainan bunyi yang hanya dapat dipahami antaranggota kelompok. Kosakata ini menjadi kode rahasia dan bahasa pergaulan yang mencerminkan kekhususan penuturnya.
PERPINDAHAN FRASA NOMINA BENEFACTIVE KE ARGUMENT-POSITION DALAM KALIMAT PASIF BITRANSITIF PADA RAGAM BAHASA LISAN ANAK USIA PRASEKOLAH
Authors: Prihatini Arti
Published: August 2019

Penelitian ini bertujuan menelaah perpindahan frasa nomina (FN) benefactive  ke Argument-Position (A-Position) pada kalimat pasif bitransitif tanpa delisi pada anak usia prasekolah. Pendekatan penelitian ini adalah kualitatif. Jenis penelitian ini adalah studi kasus deskriptif. Data penelitian ini adalah perpindahan FN ke A-Position pada kalimat pasif bitransitif tanpa delisi yang bersumber dari tuturan lisan anak usia prasekolah di Kelas B-Lion TK Laboratorium UM. Pengumpulan data dilakukan dengan teknik perekaman dan catatan lapang. Analisis data terdiri atas tiga tahap, yaitu reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa anak usia prasekolah dapat memindahkan frasa nomina benefaktif ke argument-position dengan disertai penyesuaian berupa perubahan imbuhan verba aktif menjadi verba pasif yang berimbuhan di-. Anak juga mempertimbangkan kebernyawaan (animacy) dalam proses perpindahan frasa nomina benefactive dan dalam penyusunan urutan kata dalam kalimat hasil perpindahan tersebut. Perpindahan yang dilakukan tidak melanggar subjacency condition.
TURN-TAKING MARKER ETHNICAL BUGIS AND BETAWI AT INDONESIAN CONVERSION IN INDONESIA
Authors: Juanda Juanda - , Aziz Aziz
Published: August 2019

Abstract.The conversation uses marker’s in the turn-taking. Turn-taking for participants has characteristics based on cultural backgrounds for the ethnically involved as participants. The purpose of this research is to analyze the interaction in the conversation and turn -taking and its marker’s. This research is a descriptive research. This research was used the approach of conversation analysis. The sources of data were drawn from the oral dialogue of ethnic Betawi and Bugis ethnic groups. The data retrieval by recording technique. The data analysis using Flow Model (Miles and A. Michael Huberman). The results this research show the interaction of turn taking conversations in Bugis and Betawi ethnic groups was dominated by more senior speakers and who have extensive knowledge insight. More junior speakers have a minimum speech turn. Pause or silence is a long time going when the topic will change. Transition markers in turn-taking are generally greetings and calls like Hen, Hah, Iye, Kok, Yah, Hm., Aah, Kalogitu, Ok, Goodnoon Madam!  Good Afternoon Mas !, Yes, That, Lho, Nih. These markers are influenced by native language and ethnic backgrounds of the participants. Keywords: Markers, turn-taking, Bugis, and Betawi
RESEPSI MAHASISWA TERHADAP NILAI MORAL TOKOH UTAMA DALAM NOVEL “AYAT-AYAT CINTA 1” KARYA HABIBURRHMAN EL SHIRAZY
Authors: Fajariyah Wulandari Nur , Rasyid Yumna , Nuruddin Nuruddin
Published: August 2019

Tujuan penelitian ini adalah untuk mendeskripsikan resepsi mahasiswa semester VI C Jurusan PBSI (Pendidikan Bahasa dan Sastra Indonesia) UIN Syarif Hidayatullah Jakarta yang sudah membaca novel “Ayat-ayat Cinta 1”. Resepsi mahasiswa terhadap nilai moral tokoh utama dalam novel Ayat-ayat Cinta 1 karya Habiburrahman El Shirazy tersebut mencakup: (1) nilai moral agama; (2) nilai moral kepribadian; dan (3) nilai moral sosial. Data penelitian kulaitatif ini diperoleh melalui angket dan wawancara. Prosedur pengumpulan data dilakukan dengan cara: menyebarkan angket, melakukan wawancara, mengumpulkan data, mengklasifikasi data, dan menganalisis data. Hasil penelitian menunjukkan bahwa nilai moral agama tokoh utama baik dengan persentase 9,3%, begitupula dengan nilai moral kepribadian dengan persentase 9,0%, dan nilai moral sosialnya dengan persentase 9,6%. Nilai moral tokoh utama dapat menjadi teladan dan pelajaran bagi mahasiswa sehingga dapat membentuk karakter yang kuat dalam nilai moral beragama, nilai moral kepribadian, dan nilai moral sosial.
ANALISIS PENGGUNAAN GAYA BAHASA PADA PUISI-PUISI KARYA FADLI ZON
Authors: Hasanah Dian Uswatun , Achsani Ferdian , Akbar Al Aziz Iqbal Syahrul
Published: August 2019

Di tengah arus politik yang sedang memanas mendera negeri ini, puisi menjadi salah satu bahan alternatif yang digunakan untuk menyuarakan aspirasi. Fadli Zon merupakan salah satu tokoh yang sedang hangat dibicarakan di media. Sejak kemunculan puisi berjudul “Doa yang Tertukar” dan membuat heboh publik, Fadli terus melahirkan puisi-puisi baru yang membuat suasana politik semakin memanas. Penelitian ini bertujuan untuk mendeskripsikan dan menginterpretasi gaya bahasa yang digunakan dalam puisi-puisi Fadli Zon. Penelitian ini termasuk dalam jenis penelitian dekriptif kualitatif. Sumber data yang digunakan berupa dokumen puisi-puisi Fadli Zon yang dinilai viral serta dimuat di twitter dan instagram. Puisi-puisi tersebut berjudul “Doa yang Ditukar”, “Sajak Orang Kaget”, “Arah Baru”, dan “Rakyat Bergerak”. Penelitian ini menggunakan analisis isi sebagai teknik pengumpulan data, untuk mengumpulkan dan mempelajari data tertulis puisi-puisi Fadli Zon. Validitas data diperiksa dengan triangulasi teori dan menggunakan teknik interaktif atau mengalir sebagai teknik analisis data. Teknik interaktif meliputi tahap reduksi data, sajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa gaya bahasa yang paling dominan digunakan Fadli Zon seperti personifikasi, innuendo, sarkasme, sinisme, epitet, aliterasi, epizeukis, anaphora, dan andiplosis. Beberapa gaya bahasa yang ditemukan dalam puisi-puisi Fadli Zon tersebut, bertujuan untuk memberikan penekanan makna salah satunya yaitu untuk menyindir kebijakan pemerintah yang dianggapnya tidak sesuai dengan keinginannya.
SOCIAL SUPPORT PERCEPTION AND SUCCESSFUL AGING AMONG JAVANESE PEOPLE
Authors: Karmiyati Diah
Published: August 2019

The objective of this research was to obtain a correlation between social support perception and successful aging among elderly Javanese people. This research was conducted by using quantitative correlational design. The method was intended to determine the contribution social support on successful aging. Subject of this research was the elderly whose the member of some elderly organization in Solo and Malang. The sampling technique used was purposive sampling based on the prescribed criteria of research subjects. Then, the collected data were then analyzed by using Pearson Correlation Method. The findings of this research showed that there was a significance positive correlation between social support perception and successful aging among Javanese people.
Cerpen Agama Apa yang Pantas Bagi Pohon- Pohon? Karya Eko Triono sebagai Media Kritik Alternatif terhadap Masyarakat Postmodernisme
Authors: Sastra Yulaika Ranu
Published: August 2019

Masyarakat modern saat ini telah mengalami perubahan secara signifikan baik dari segi pola pikir, maupun tingkah laku. Perubahan ini bertentangan dengan hakikatnya sebagai manusia modern. Pergeseran tatanan norma-norma tersebut memunculkan teori posmodernisme. Dari postmodernisme inilah bermunculan pula berbagai kritik terhadap manusia sebagai subjek kehidupan. Seiring berkembangnya zaman, beragam teori dan aliran sastra pun bermunculan untuk membedah karya. Karya sastra dikaitkan berdasarkan teori yang tepat agar maksud si penulis tersampaikan kepada pembaca melalui penafsir. Ada pun mata pisau untuk membedah cerita pendek Agama Apa yang Pantas bagi Pohon-Pohon? karya Eko Triono menggunakan pendekatan postmodernisme. Cerpen ini dipilih sebagai media kritik alternatif karena mewakili kehidupan manusia modern. Terdapat beberapa hasil terhadap penelitian postmodernisme dalam cerpen tersebut, yakni manusia posmodern mengesampingkan pemahaman agama sedini mungkin kepada anak, ketidaksiapan manusia postmodern menghadapi realita, masalah diri sendiri dengan orang lain dan masyarakat, manusia postmodern tidak lagi mengindahkan kedamaian, dan permasalahan percintaan masyarakat postmodern saat ini.
Romantisme Perempuan Muda Sasak dalam Antologi Puisi Eulogi
Authors: Mahyudi Johan , Agusman Agusman
Published: August 2019

Tujuan utama tulisan ini ialah menguraikan kombinasi pendekatan penelitian impresionistik, estetik, dan romantik sebagai metode yang memadai untuk menguraikan ideologi yang termuat di dalam sebuah antologi puisi. Metode estetik-romantik digunakan untuk mengeksplorasi bahasa-bahasa khas yang ditemukan dalam antologi Eulogi, yang jika dikaitkan dengan gagasan Shelley, Ingarden, dan Eagleton, optimalisasi bahasanya hanya bisa dinilai dari seberapa mampu puisi tersebut mendorong pembacanya berkontemplasi dengan menghadirkan bahasa yang indah. Hasil penelitian menunjukkan, Karwayu menulis puisi-puisi dalam antologi Eulogi bertujuan mengungkapkan perikehidupan rahasianya. Ungkapan rahasia kehidupan peribadi dengan bahasa yang indah tersebut, kian mudah dipahami berkat pengaturan urutan puisi oleh editor yang mudah menuntun pembaca untuk menemukan narasi pemberontakan jiwa perempuan Sasak dalam plot yang bergerak maju menuju akhir yang mengejutkan. Dari kelima puluh puisi yang terjalin kuat membangun romantisme perempuan Sasak, puisi-puisi tertentu bergerak pada level romantik yang lebih tinggi, yaitu pengungkapan prinsip-prinsip filosofis. Salah satu prinsip ideologis yang menonjol ialah pernyataan tegas Karwayu menolak segala upaya merusak perdamaian, apalagi jika dilakukan oleh pemuka agama dengan memanfaatkan mimbar di rumah ibadah. Mimbar dari seribu masjid di Pulau Lombok, menurutnya hal itu harus tetap dijaga agar menjadi sumber energi perdamaian di nusantara.
Refleksi dan Evaluasi Stigma 5 Festival Monolog Nasional di Universitas Negeri Malang
Authors: Marciano Roci
Published: August 2019

Monolog dalam seni teater dan drama penting untuk di pelajari saat ini, karena memberikan dampak positif bagi seorang aktor, baik itu di atas panggung, maupun pada kehidupan itu sendiri. Kecerdasan yang bisa dipelajari dalam belajar monolog tentu saja bukan hanya berani tampil sendirian di atas panggung dengan menyampaikan kisah. tetapi nilai yang paling berharga adalah ketika seorang manusia mampu menghapalkan hasil pemikiran seorang penulis naskah, merespon segala tatanan artistik dengan kecerdasan lahiriah dan batiniah sebagai perangkat keaktoran untuk disampaikan kepada penonton. Refleksi dan evaluasi perlombaan, perlu disampaikan demi kemajuan para pelaku monolog.
Hegemoni Maskulinitas dalam Under The Greenwood Tree Karya Thomas Hardy
Authors: Wardani Agista Nidya
Published: August 2019

Penelitian ini berfokus pada bagaimana hegemoni maskulinitas yang terjadi pada tiga tokoh laki-laki di novel Under The Greenwood Tree (1872) karya Thomas Hardy, khususnya pada tokoh utama laki-laki bernama Dick Dewy. Metode penelitian yang digunakan dalam penelitian ini adalah metode deskriptif dengan menggunakan teori hegemoni maskulinitas Raewyn Connell. Dari penelitian, ditemukan bahwa Dewy tersubordinasi dari kedua tokoh laki-laki lainnya, Shiner dan Vicar Maybold, karena Dewy berasal dari kelas bawah. Namun, pada akhirnya, Dewy tidak lagi tersubordinasi karena dia memiliki sesuatu yang menjadi standar ide komunal atau ide masyarakat untuk dianggap sebagai laki-laki yang kuat, yaitu memiliki kekayaan dalam jumlah banyak.