bluuebunny/crossref_metadata_2025 huggingface dataset:
Hierarchically Assembled Theranostic Nanopolyplexes Enable Robust Tumor Gene Therapy and Magnetic Resonance Imaging In Vivo
Authors: Li Dan , Jiang Wen , Xu Xingting , Cui Zhijun , Zhuang Zhigang , Lin Chao
Published: January 2020

Theranostic nanosystems encompassing imaging reagents and therapeutic genes are promising for concurrent tumor diagnosis and gene therapy. In this work, we developed bioresponsive gadolinium (Gd)-based nanopolyplexes (denoted as Gdplexes) for in vivo tumor theranostic applications.
Gdplexes were generated by a hierarchical assembly method involving the neutralization of DNA with a Gd-chelated bioreducible cationic polyurethane (termed as GdCPUA), which was followed by condensation of DNA with a cationic dextran conjugate (DP800). By adjusting GdCPUA/DP800 ratios, the
resultant Gdplexes had GdCPUA/DNA complex as an inner core and a dextran outer shell; thus, Gdplexes exhibit an improved colloidal stability under physiological conditions and perform active gene release in an intracellular reductive environment. In vitro tests against cancer cells
revealed that optimized Gdplexes afforded comparable transfection efficiency to that of the 25 kDa branched polyethylenimine used as a positive control. Additionally, the Gdplexes could robustly transfer small hairpin RNA plasmids to silence vascular endothelial growth factor expression in
SKOV-3 cells. In vivo, the Gdplexes loaded with plasmid were practical for systemic gene delivery via intravenous administration, yielding marked growth repression of an SKOV-3 tumor xenograft in a BALB/c nude mouse model. The tumor could be visualized by T1-weighted magnetic resonance
(MR) imaging. Such efficient gene therapy had no adverse effects on hepatorenal functions and weight gain in the mouse. This work highlights Gdplexes as biosafe and robust nanocarriers for tumor theranostic applications in vivo.
Real-Time Electrochemical Detection of Uric Acid, Dopamine and Ascorbic Acid by Heme Directly Modified Carbon Electrode
Authors: Feng Xiao-Zhen , Su Xiaorui , Ferranco Annaleizle , Chen Zhencheng , Han Guo-Cheng , Jiang Zhiliang , Kraatz Heinz-Bernhard
Published: January 2020

Several simple electrochemical sensors were designed for three analytes, uric acid (UA), dopamine (DA) and ascorbic acid (AA) detection via electrolytic deposition of three functional materials heme, Fc(Cys)2 and Fc-ECG onto glassy carbon electrodes (GCEs) without other medium.
Characterization of the modified GCEs was conducted using SEM, TEM and DPV methods. Results showed that the heme/GCE demonstrated notable electro-catalytic capabilities, towards DA, AA, and UA oxidation in a solution of phosphate buffer. The current signals of DPV technique for three analytes
shown up three defined oxidated peaks, the peak potential differences was 192 mV for AA and DA, and 142 mV for DA and UA. Under optimal conditions, it can be obtained linear responses for AA, DA and UA in the following concentration ranges: 10 to 50, 5 to 20, and 2.5 to 20 μmol·L–1,
and the limits of detection was calculated as 0.76, 0.50 and 0.63 μmol·L–1, respectively. The results demonstrated that the heme directly modified GCE was a well-suited electrochemical sensor for determining UA, DA and AA in actual samples.
Building Information Modeling (BIM) Benefits and Challenges: Malaysian Construction Organization Experience
Authors: Musa Suria , Marshall-Ponting Amanda , Shahron Syairah Aimi , Abdul Nifa FaizatulAkmar
Published: January 2020

Building Information Modeling is an innovative technology coupled with process and human interactions. BIM has been used by the Architecture, Engineering, and Construction (AEC) industry in developed and developing countries including Malaysia. This paper aims to explore the BIM implementation
in Malaysian Construction Industry. This paper begins with a literature review and then reports on the findings of case studies of selected Malaysian construction organizations, carried out with the aim to explore on existing BIM implementation establishing on the BIM applications, BIM benefits,
and BIM future challenges. The review highlights on several BIM benefits regarding financial, better information, communication and coordination, respond to complexity, improved visual, improved sustainability, improved safety and also create service’s or business’s opportunities.
Case study findings indicate that the BIM implementation in projects are still limited and requires more efforts to be made if the construction industry wants to gain BIM benefits. The results also indicate that although BIM implementation is considered low in the Malaysian construction industry,
the participants are in a consensus of the benefits from BIM implementation, similar to those found in the literature. These benefits agreed by the participants that BIM implementation is a positive way to enhance the task efficiency in project delivery and also contribute to the higher visibility
of the project, together with time and cost optimization. Furthermore, in the meantime, the organization that has the knowledge and skills in implementing BIM could benefit the opportunity in getting the new job or projects as well as being hired as the service provider in the construction
industry. Nevertheless, implementing BIM is not without challenges. The data analysis had identified several challenges in regards to the implementation of BIM, which are non-technical (human and organizational culture) challenges and technical (technology) challenges. Thus, based on many
future challenges for BIM, the Malaysian government and construction industry players need to collaborate and play their roles in supporting BIM development in Malaysia.
Alginate-Inulin Hydrogel: Synthesis and Development for Targeted Delivery of Protein
Authors: Norudin Norsyazwani Solehah , Mohamed Hajaratul Najwa , Mat Yahya Nor Aisyah
Published: January 2020

Recently, a lot of strategies have been developed to enhance oral protein delivery. The combination of biodegradable polymer which is alginate-inulin as the material for hydrogel matrices was studied as a carrier of BSA which was used as a model protein. The effects of different formulations
on the BSA release profile in physiological saline was investigated. Meanwhile, the compatibility of protein and polymer was characterized by FT-IR spectroscopy. High BSA encapsulation efficiency was found with the increase of inulin amount in the hydrogel matrices. The BSA release pattern
showed that the minor released of BSA in simulated gastric fluid, SGF pH (1.2) throughout 2 hours’ incubation and after changing the solution into simulated intestinal fluid, SIF pH (7.4) the protein release started to increase gradually up to 100% within 90 minutes. Incorporation of
inulin in the alginate beads also resulted in improved BSA release in physiological saline solution. In addition, swelling behavior revealed that highest swelling rate of hydrogel was in alkali solution indicating that alginate-inulin hydrogels were influenced by the pH of test medium. The
FT-IR results show that encapsulating matrices are compatible with protein and can be used as drug carrier. Therefore, the alginate-inulin hydrogel showing a good efficiency in oral administration of protein drug.
Application of Polyethylene Terephthalate Concrete as Paver Block
Authors: Ahmad Nor Farah Atiqah , Razali Siti Nooraiin Mohd , Sahat Suhaila , Kaamin Masiri
Published: January 2020

This research is carried out to investigate the performance of concrete containing Polyethylene Terephthalate (PET) bottle waste as fine aggregate. PET bottle waste was chosen because it is being thrown after single use and cause environmental problem. This PET concrete then will be
applied as a paver block for pedestrian walk. To reduce waste PET, the PET bottles was recycled and used in concrete mixture as a fine aggregate. PET bottles was cleaned and grinded into small irregular shape. Then, it was incorporate with the concrete and the test was conducted to find out
the suitable strength for PET concrete that will be applied as paver block. The study was conducted by using cube mould to investigate the strength of the concrete. A total of four batches of concrete were produced namely, standard concrete and concrete containing PET of 5%, 10% and 15%. In
this research, the compressive strength of the concrete were measured following British Standard method. The results revealed that the presence of PET in concrete will decrease the concrete performance. Nevertheless, the content of PET was specified in a specific limit to avoid the effect
of concrete strength.
Accessibility, Security, Trust, Service Quality, and Satisfaction the Most Significant Antecedents Affects Online Banking Users
Authors: Esmail Alekam Jamal Mohammed , Mohd. Mokhtar Sany Sanuri bin , Salleh Salniza Bt Md.
Published: January 2020

Online banking adoption among young generation, antecedents, and consequences is the current and important issue, therefore the objective of this research is to analysis, the antecedents and consequences of Intention and Satisfaction that affect online banking adoption. This research
was carried out because lack of studies in this area, however, this research have examined the influence of security, trust, on the intention to use online banking and examine the relationship between intention to use online banking and adoption of online banking. In addition satisfaction
on the adoption of online banks among young generation. The Partial Least Squares Structural Equation Modelling (PLS-SEM) was employed in the data analysis. The findings revealed a strong significant relationship between the variables. The study concludes with a discussion on the contributions,
limitations as well as suggestions for future research. This electronic document is a “live” template and already defines the components of your paper [title, text, heads, etc.] in its style sheet.
Does Main Contractor Influence Subcontractor Bullying?
Authors: Hidzir Nur ’Izzati , Jaafar Mastura , Dahalan Norziani , Bakar Syed Putra Syed Abu
Published: January 2020

Workplace bullying is currently a normal issue that proliferates worldwide. Essentially, research related to this topic has been conducted in many different fields and industries, but it remains scarce in construction sector. This paper explores the subcontractor bullying in Malaysian
construction industry and identifies the impact of main contractor to subcontractor bullying. Data collection was implemented on 210 contractors of Grade 6 and 7 across Peninsular Malaysia. Based on Partial Least Squares—Structural Equation Modelling (PLS-SEM) analysis, the findings
reveal that main contractor leadership and project organisation affect work-based bullying. However, the relationship between project organisation and job design with physical intimidating bullying was found to be not significant. The result of this study may assist the main contractors to
understand their role in providing a better environment for the sake of project success.
Performing Analysis of Quality of Service Parameters of 4G Long Term Evolution in Health Care System
Authors: Rangankar Suresh B. , Mhala Nitiket
Published: January 2020

Long Term Evolution (LTE) is a leading 4G wireless broadband technology developed by the Third Generation Partnership Project (3GPP) Release 8. LTE is expected to provide very fast, highly responsive and cost effective data services and appears itself to be the right technology at the
right time. LTE is becoming an ultimate choice for 4G services around the world due to its higher data rates and lower latency objectives. E-Health services comprise a wide range of healthcare services delivered by utilizing information and communication technology. In order to help existing
and emerging e-Health services over converged next generation network (NGN) architectures, there is a need for network QoS control mechanisms that meet the often stringent requirements of such services. The mobile Health (m-health) is currently uniting major academic research worldwide to
achieve innovative arrangements in the areas of healthcare. However, there are several challenges and issues that need to be addressed. In this paper we have proposed m-health care system based on 4G LTE network communication instead of existing 3G communication system. We will be monitoring
QoS parameters like Delay, Throughput, Jitter, Energy Efficiency and Packet Data Rate for comparing 3G and 4G LTE usage over health care applications. We will further experiment the parameters with graph based analysis.
Proposing an Enhanced Youth Training Module for Fostering Spiritual Foundation
Authors: Abd Ghani Abdullah , Maamor Selamah , Razimi Mohd Shahril Ahmad , Abd Wahab Norazlina , Aziz Ahmad Bashir , Nik Abdullah Nik Safiah , Elias Nor Hanim
Published: January 2020

Recently the emergence of sensitive issues related to spiritual or believe among nation occurred. All these kinds of issues must be tackled from the grass root especially among youth. In relation to the above issues, government as well as private sectors manages to setup various activities
in order to develop and improve spirituality among youth. Even though many activities have been implemented for a long time and a lot of cost, including time and money spend, the effect of spirituality activities among youth are not certain. Therefore, the objective of this paper is to explain
a training module for nurture spiritual foundation among youth in building and fostering a self-identity. It is enabling them to confront trials and challenges and subsequently persevere in developing an excellent and visionary personality based on the First National Principle, ‘Belief
in God.’ In this paper, we explain the process of the development of the MY Spirituality module; the delivering method as well as the intervention session to test runs the module. Finally, this paper also shares the feedback from the implementation of a spirituality program using the
module.
An Optimized Cloud Architecture for Integrity Verification
Authors: Arora Shakti , Dalal Surjeet
Published: January 2020

Cloud has become popular in today’s environment of IT industry where all types of services whether hardware, software, or storage can be availed at one place and can be used efficiently. When we use hardware and software then there is very less chance of risk but when we deal
with storage then we are storing our personal data on the cloud which is not transparent to user. In proposed model we introduced hybrid technique which provides security and assurance beyond Service Level Agreement. We proposed a strong integrity verification mechanism at the time of recovering
a file/data. Hardness/strength of the key or the shared file is increased up to maximum level i.e., 7.9. Integrity of the proposed system is compared with the standard cloud’s integrity and approximately we gain 60% higher level of integrity other than the standard cloud nodes.
A Quantitative Testing Effort Estimate for Reliability Assessment of Multi Release Open Source Software Systems
Authors: Sangeeta  , Sharma Kapil , Bala Manju
Published: January 2020

Growing software demand in the present virtual world introduces new competitive dynamics for software developers. Recently, Open Source Software (OSS) systems are providing a faster way of software production. To survive in the competitive market, developed OSS system needs enhancement
in previous versions. Each enhanced versions are found to be more liable to risks of failures. In the recent software development process, the primary concern of researchers is always to find new ways for assessing the reliability of developed OSS versions. To incorporate modern software development
environments and technologies, new failure rate model for reliability estimation of multiple versions of OSS systems has been developed in this paper. Proposed model incorporates a new testing effort factor for integrating varying needs in each release of software development. It comprises
imperfect debugging with the possibility of fault introduction. The proposed model has been validated on various releases of Firefox and Genome project failure data set. Parameter estimation for the proposed model has been done using a flower pollination algorithm. Experimental results have
shown the enhanced capability of the proposed model in comparison to Goel-Okumotto model, Inflection S-shaped model and PTZ model in simulating real OSS development environment.
The Threat Detection Framework for Securing Semantic Web Services
Authors: Singh Nagendra Kumar , Nayak Sandeep Kumar
Published: January 2020

Security is a necessary aspect of modern life for organizations and individuals who use the semantic web to provide various services. Semantic web applications are being used as a portal to communicate with back-end database systems and to support business processes. The confidential
and personal information of any organization is stored on these systems. Access Control ensures that the requesting user has to meet certain criteria to access these systems. In most cases, it has been observed that access control only provides protection against external threats. There is
no provision for detecting internal attacks. Therefore, there is a need for a mechanism that can be able to detect the malicious behaviour of previously authorized users. This paper proposes two algorithms to detect anomalous behaviour performed by the legitimate insider. During training phase,
the first algorithm will create the query signature of each incoming query submitted by the legitimate insider. It also estimates the amount of data that can be extracted by the submitted query and includes in the query signature. The second algorithm will detect incongruous data extraction
from the database by comparing the current query signature with the previous signature. If both signatures are identical, the query is considered safe for execution. Otherwise, the query will be considered as threat. In this paper, efforts are being made to give details of the security structure
on the semantic web service.
A Comparative Study of Linear and Non-Linear Classifiers in Sensory Motor Imagery Based Brain Computer Interface
Authors: Chaudhary Poonam , Agrawal Rashmi
Published: January 2020

Over the period of 4–5 decades of the field electrophysiology on neural signal events in single cell recording, it can be concluded that there is production of far field potentials containing near synchronous field patterns might reach at the scalp electrodes. These neural signals
then can be analyzed and converted into the control signals for computers and other electronic devices. Electroencephalography (EEG) is a method to acquire these neural signals from the scalp of human brain. EEG signals are simple, economical and have high temporal resolution properties. These
properties make it advantageous to use widely in the medical as well as non-medical applications. The event related synchronization and desynchronization (ERS/ERD) pattern present in EEG during sensory motor imagery (SMI) process over the cortical area is an important feature to take BCI towards
realistic approach. The accurate classification of these ERS/ERD pattern present in EEG signal is dependent on classification accuracy of different classifiers. So, the objective of the paper is to analyze the classification accuracy of linear and non-linear classifiers used for BCI system
design. This paper also presents the comparative study of linear (Linear discriminant analysis and Support Vector Machine) and non-linear classifiers (Bayesian and Radial Basis Function-Support Vector Machine) using BCI competition IV dataset 2a. The result concluded that linear classifiers
(LDA and SVM) have outperformed the non-linear classifiers on EEG data with the average performance across subjects 75.26±12.23, 72.42±11.12.
An Interval Type 2 Fuzzy Logic Framework for Faster Evolutionary Design
Authors: Singh Sarabjeet , Singh Satvir , Banga Vijay Kumar
Published: January 2020

In this paper, a fast processing and efficient framework has been proposed to get an optimum output from a noisy data set of a system by using interval type-2 fuzzy logic system. Further, the concept of GPGPU (General Purpose Computing on Graphics Processing Unit) is used for fast execution
of the fuzzy rule base on Graphics Processing Unit (GPU). Application of Whale Optimization Algorithm (WOA) is used to ascertain optimum output from noisy data set. Which is further integrated with Interval Type-2 (IT2) fuzzy logic system and executed on Graphics Processing Unit for faster
execution. The proposed framework is also designed for parallel execution using GPU and the results are compared with the serial program execution. Further, it is clearly observed that the parallel execution rule base evolved provide better accuracy in less time. The proposed framework (IT2FLS)
has been validated with classical bench mark problem of Mackey Glass Time Series. For non-stationary time-series data with additive gaussian noise has been implemented with proposed framework and with T1 FLS. Further, it is observed that IT2 FLS provides better rule base for noisy data set.
An Effort to Reduce Voltage from DC to DC Converter with a Monolithic Circuit Based on IC LM 2596
Authors: Cekdin Cekmas , Nawawi Zainuddin , Faizal Muhammad
Published: January 2020

Step down regulator is a device that can reduce the more significant input voltage to a smaller output voltage. The output is stable and well regulated, although the voltage fluctuates in the recommended input voltage range. In the system using IC LM 2596, the input voltage is 40 Volt
dc, and the output voltage is 30 Volt dc. The output current of 15 amperes is applied to charge a 100 Ampere hour (Ah) battery on an inverter system installed and integrated with other electronic devices. The step-down IC LM 2596 will be stable at the output current below 15 Ampere. It is
especially stable at load currents from 13.2 Ampere to 14.57 Ampere. In order for the current not to shrink, a good cooling system must be designed to dispose of heat on the IC LM 2596. Because the high heat greatly affects the output current on the IC LM 2596.
Profile Voltage on One Phase Cable Channel at Every Distance 17 Meters in All 102 Meter That was 1000 Watt with Least Square Method
Authors: Sofiah  , Majid Abdul , Cekdin Cekmas
Published: January 2020

In this paper, it is discussed to determine a voltage modeling on a 102 meter one-phase cable channel which is loaded with a 1000 Watt lamp with the least square method. To obtain this method is by measuring the voltage at the points specified in the cable. After the measurement data
is obtained then it is calculated to determine the mathematical model with the least square method. The least square method is a method for predicting a certain price. This method is also called the smallest quadratic method with the equation V = a + bX. With V is the measurement
voltage (Volt) at distance X from the source, X distance from the source (meter), n ila a and b are calculated based on the measurement data. After the equation model is obtained, then we compare it with the measurement results. This comparison is useful
to know what percentage difference between the results of the measurement and calculation.
The Effect of Type and Concentration Yeast with Fermentation Time and Liquifaction Variations on the Bioethanol Concentration Resulted by Sorgum Seeds with Hydrolysis and Fermentation Processes
Authors: Roni Kiagus A. , Kartika Dorie , Apriyadi Hasyirullah , Herawati Netty
Published: January 2020

Sorghum is one of the plants that can be used as raw material for making bioethanol. Sorghum has seeds with a starch composition of 73.8%, which is potential as a raw material for making bioethanol. Sorghum starch can be converted into bioethanol through the hydrolysis process (the
process of converting carbohydrates into glucose) which consists of liquefaction and saccharification processes and is followed by a fermentation process. The hydrolysis method is carried out enzymatically. In this study alpha amylase and gluco amylase enzymes were used with various types
of yeast including Saccharomyces cerevisiae, Rhizopus oryzae, Acetobacter xylinum, Mucor sp, and Aspergilus niger which varied with liquefaction temperatures including 80, 85, 90, 95, and 100 °C. Obtained the most optimal yeast is Saccharomyces cerevisiae with an optimal
temperature of 95 °C resulting in a bioethanol concentration of 4.3%. After getting the optimal yeast and temperature, the fermentation step of the two variables is used in the next step. In the fermentation process, variations of yeast concentration and duration of fermentation were used,
the optimum yeast concentration was at 2.5% with 48 hours of fermentation resulting in bioethanol concentration of 11%.
Diagnostic Signal Informativeness Increase
Authors: Kharlyamov Damir Afgativich , Suleimanov Ilnar Fargatovich , Sabirova Alsu Ildarovna , Penkov Evgeniy Aleksandrovich , Kalimullin Ruslan Flyurovich
Published: January 2020

Modern requirements for the operation of cars lead to the need to improve the efficiency of their maintenance. Diagnosis as an element of the maintenance process allows you to provide information about the technical condition of a particular element, which allows you to respond in a
timely manner to the technical condition change of a diagnostic object with minimal resources. In this paper, we consider the way improving the diagnostic signal quality. It is known that a diagnostic signal must meet several requirements. The most important requirement is informativeness,
which shows the decrease of uncertainty about the technical condition of an object, represented by a priori entropy after information application from this diagnostic signal, measured during the diagnosis. There are the methods for a diagnostic signal conversion, which allow to get rid of
the noise entering it to a different degree or present it in such a way to facilitate the signal analysis process. Three methods are considered in the work: direct spectrum obtaining, signal envelope spectrum obtaining, and adaptive filtering. The analysis of these methods led to the conclusion
that adaptive filtering has the greatest efficiency potential. We have proposed the method that is based on adaptive filtering, but with additional operations. In the course of the diagnostic signal studies and the adaptive filtering algorithm, we found that it is possible to set the function
to be detected as a variable, as well as several parameters that affect the result quality. Based on this, a new method for a useful signal extraction was proposed. The results of the work were checked on a signal simulating a car gearbox signal. The results show that the method allows you
to obtain the necessary knowledge about a defect, which can be used in the diagnosis. The developed method allows to increase the information content of the diagnostic signal by suppressing its other components. The results of the proposed method correlate with the results of other methods
for general cases, i.e., when the ratio of the useful signal to noise is such that high sensitivity of the method is not required to identify the useful signal.
Development of the Concept of the Synthesis Methodology of Treatment Schemes of Complex Form Surfaces
Authors: Malneva Julia Andreevna , Altukhov Aleksandr Yuryevich , Vorobiev Evgenii Alexandrovich , Petrovna Kuznetsova Luibov
Published: January 2020

The article describes the development of the methodology concept for the synthesis of complex surface treatment schemes. The design of the technological equipment elements, namely, the machine, metal-cutting tools is currently performed individually. On the basis of the proposed concept
of the methodology for the synthesis of machining diagrams for parts with double curvature surfaces, it is advisable to consider the synthesis process as a system of interrelated functional transformations: description of the processed surface; synthesis of initial structures; modification
of initial structures; synthesis of tool-making surfaces; forming the space of project parameters of tools. In order to form the space of project parameters, within the framework of the transformation “Forming the space of project parameters of tools,” it is advisable to build
a complex of mathematical models, which will allow creating the space of the initial design parameters essential for a given project level in the early design stages, and establish analytical dependencies (dimensional relationships and material properties) between the design parameters and
the main indicators of quality.
Robots for a Detailed Study of Moon
Authors: Saprykin Oleg , Tolstel Oleg
Published: January 2020

The problem of a detailed study of the Moon is considered—the phase of the study in which a person has either not yet begun manned flights, or makes them no more than once a year. At this phase, it is very important to conduct detailed studies of the substance in various regions
of the moon, which should directly affect the pace, scale and scenarios of the exploration of the moon. The authors, relying on a list of scientific research on the moon that is relevant for the coming decades, offer the appropriate tools—automatic and semi-automatic (with elements of
artificial intelligence) robots. It is shown that scientific tools and the necessary robotic systems can be unified and reduced to a relatively small list. Of particular interest is the reusable use of scientific equipment and related robotic systems. Reusable execution of robots, their maintenance
on the lunar surface by robots themselves or on board a near-moon station can significantly reduce the time of exploration of the moon and go to the phase of its development—the pace of research can be increased by an order of magnitude. A key element in the proposed concept should be
a reusable take-off and landing vehicle (MVPA). Its creation will ensure the reusability of the use of robots on the moon. In addition, the authors conclude that it is necessary to deploy an automatic lunar orbital station (LOS) in a low lunar orbit, the main task of which will be the maintenance
of replaced equipment and the refueling of MVPA. Authors present configurations of promising robot platforms for scientific equipment for a detailed study of the moon. Features of the use of anthropomorphic robotics on the moon are considered separately. Recommendations are given on its use,
implementation of elements of the artificial intelligence system. In combination with proposed MVPA concept and reusable scientific equipment, the use of anthropomorphic technology will ensure the telepresence of research scientists on the moon, regardless of the fact and speed of manned flights.
Earthquake Risk Analysis and Qualitative Comparison of Attenuation Relationships in Garmsar City, Iran
Authors: Shahrab Khalil Arab , Mirzakhani Abuzar
Published: January 2020

Despite the scientists’ wide efforts to determine earthquake risks all around the world, it is not still possible to predict the exact time, location and magnitude of future earthquakes and aftershocks at the ground surface so precise results are not predictable within near future.
The most significant reason for this relates to numerous complexities of earthquake mechanism and causal conditions and waves through different ground layers with completely different properties. Logical tree method was used with weights to determine acceleration spectra due to spectral nature
of region. Probabilistic analysis of earthquake hazard was done using SEISRISK III program. The analysis results are proposed through spectral acceleration maps for 50 years in Garmsar. Moreover, uniform hazard spectrum and spectrum with constant shape are presented.
The Analysis of Application Information System as e-Business GO-BABY Application of Child Care in Bandung
Authors: Sitanggang Andri Sahata , Fenny Syafariani R.
Published: January 2020

The purpose of this research is to provide solution by approach through analysis about the problem by homemakers who have children. The condition of being happens is limited have time in childcare are responsible for a woman and limited childcare in Bandung City. As for research, methodology
is based on method action research, in the first year the interview, observation, documentation, and processing statistical data. Research methodology will produce calculation statistical housewives data, the problems, then solution in solving problems of application design mobile of GO-BABY
is reservations online for child care based on android, and iOS, and does that which is the integration data to centralized system.
Web-Based Environmental Learning Information System in SMA Angkasa Lanud Husein Sastranegara Bandung
Authors: Wahyuni W. , Fadryan Erzy Pratama , Sitanggang Andri Sahata
Published: January 2020

The Purpose of this research is to build an information system application to help teachers and students in high school in learning environmental education. Angkasa Lanud Husein Sastranegara Bandung Senior High School is an adiwiyata green school project, they also have an environmental
friendly institution curriculum that is environmental education. The method used for this research is descrptive method. His method is carried out by examining an existing event and analyzed by interview and observation data collection technique. The result of this research is an application
of environmental learning information systems that can help the learning process of students and teachers to achieve the appropriate target material and interactive learning so that students can easily understand the contents of the material provided.
Optimization Approach to Automation of Multiple-Path Synthesis of Design Solutions in the Integrated Design of Evolving Systems
Authors: Ryndin Nikita Alexandrovich , Sapegin Sergey Vladimirovich , Ryndin Alexander Alexeevich
Published: January 2020

Background: In the context of the global digital transformation of the modern society the rationalization of the software development process remains one of the most relevant issues. The article suggests an approach to automation of multiple-path synthesis of design solutions
for a given class of information systems (IS) namely evolving systems. Objectives: The goal of the research is the development of a methodological framework for the rationalization of the process of building Evolving Information Systems. Methods: The article uses methods of linear
and nonlinear optimization, system analysis, theory of information processes and systems. Results: As a result of the research, the developed approach to building evolving information systems is proposed. The article considers the basic principles of a rational approach to multiple-path
synthesis and describes the steps of algorithm and features of its applying to the IS building project.
Application of Micro-CT in the Examination of the Influence of Different Intensities of Exercise on the Injury of Junction of Bone and Tendon
Authors: Lu Dinggui , Tang Qianli , Wei Jihua , He Fengying , Tang Yujin
Published: January 2020

The purpose of this study was to investigate the effect of different intensities of exercise on the injury of the junction of bone and tendon. In this study, the feasibility of Micro-CT technology to calculate the thickness of fibrous cartilage band was investigated experimentally.
Adult female New Zealand white rabbits were selected as the study subjects and randomly selected into 4-week cyclic load group (n = 8) and 8-week cyclic load group (n = 8). Among them, left hind limb was used for experiment and right hind limb was used as blank control. The results
showed that the tissue morphology of the bone tendon junction was changed in each load group, while the tendon cell density was significantly increased in the high-exercise load group, and there was no significant difference in the thickness of the fibrous cartilage band. Micro-CT calculation
results of bone mass and trabecular bone showed no significant difference between the experimental group and the control group. Therefore, it can be concluded that the intervention of different strength load train and rest on the injury of the junction of the patella and tendon can change
the fine structure of the bone, but not the tissue changes of the junction of bone and tendon, and the bone reconstruction and recovery ability is stronger than the junction of bone and tendon.
Data Estimation of Injury-Prone Sports by 3D Image Joint Probability Distribution
Authors: Tang Xun
Published: January 2020

The objective of the paper is to study and analyze sports injuries from multiple perspectives. The reduction of damage risk factors of young athletes in sports would reduce or avoid the occurrence of sports injuries. The obtained point cloud data is preprocessed by three-dimensional
(3D) image technology for the registration of the cloud data to be registered. The parallel Bayesian network structure was established to realize the parallelization of the probability distribution estimation algorithm. The research results have shown that the parallel probability distribution
estimation algorithm would provide a great degree of efficiency improvement in terms of solving continuous function optimization and real-time optimization problems, as well as the problems of improving the efficiency of the algorithm to some extent. It could be inferred that the combination
of improved rasterized nearest point search method has shortened the search time of the nearest point, thereby improving the efficiency of the algorithm. The correctness and rationality of the algorithm were verified from both theoretical and practical perspectives.
Research on Digital Information System Construction and Intelligent Management of Clinical Pediatric Nursing in Hospital
Authors: Cao Yanan , Zhu Hui
Published: January 2020

The paper uses the prototype method and modular design idea to modularize the pediatric nursing information management system, program with Visual FoxPro5.0, and test the clinical pediatric nursing information system. The system optimizes the pediatric nursing process, improves the
efficiency of medical staff, and greatly reduces the problems of medical records loss, errors, and supervision. After the pediatrics run this information management system, the leaders can grasp the indicators of the quantity, quality, efficiency, efficiency and management of each group, which
is conducive to strengthening the management of pediatrics and guiding the healthy development of pediatrics. Through the assessment and evaluation of individuals engaged in medical work, grasp the objective data of medical staff's business ability, work performance, medical ethics, job qualifications.
Provide a reliable basis for pediatric appointment, training, promotion, and distribution.
Complementary Metal Oxide Semiconductor Amplifier Behaviour Considering Different Points of Electromagnetic Interference Injection
Authors: Becchetti Simone , Richelli Anna , Colalongo Luigi , Kovacs-Vajna Zsolt M.
Published: January 2020

In this paper the CMOS amplifier behaviour has been further investigated respect to the previous works in the literature. An exhaustive scenario for the EMI pollution has been considered: the injected interferences can indeed directly reach the amplifier pins or can be coupled from
the PCB ground. This is a key point for evaluating also the susceptibility from the EMI coupled to the output pin, which is disclosed as a critical point. The investigated topologies are basically derived from the Miller and the Folded Cascode, which are well-known and widely used by the CMOS
analog designers; all of them are re-designed in UMC 180 nm CMOS process in order to have a fair comparison.
Geothermal silica-based fluorescent nanoparticles for the visualization of latent fingerprints
Authors: Jenie Aisyiyah S. N. , Krismastuti Fransiska S. H. , Ningrum Yudia P. , Kristiani Anis , Yuniati Mutia D. , Astuti Widi , Petrus Himawan T. B. M.
Published: January 2020

The development of silica nanoparticles from the waste of geothermal power plants and their subsequent modification using a fluorescent dye, rhodamine 6G (R-6G), has been reported. The optimum specific surface area of the silica nanoparticles before modification was 289.2 m2
g–1. After modification, the intrinsic properties of the fluorescent silica nanoparticles were studied, and the results showed that they were in their amorphous phase, with a particle size of 5–10 nm. We proposed that the interaction between R-6G and the silica nanoparticle
surface was due to the hydrogen bonding, using the results from the Fourier transform infrared spectroscopy. The obtained fluorescent silica nanoparticles had excellent fluorescence enhancement of 2-fold compared to R-6G in its original state. This study reports, for the first time, the synthesis
of fluorescent nanoparticles from geothermal silica and its ability to visualize latent fingerprints on different smooth dry surfaces, making it an excellent candidate for fluorescent powders in forensic applications.
Fast heterogeneous oxidative desulfurization of dibenzothiophene from ionic liquids supported urchin-liked meso-silica
Authors: Zhang Jinrui , Zhang Ming , Liu Jiaqi , Wang Chao , Li Hongping , Pang Jingyu , Zhu Wenshuai , Li Huaming
Published: January 2020

As air pollution and green-house effect have caused numerous environmental problems in past decades, and increasing investigations have been focused on reducing the emission of harmful gas such as SOx. Oxidative desulfurization of fuel is considered as a promising
method for its high efficiency and mild condition. Herein, ionic liquids supported urchin-liked meso-silica were facilely prepared and applied for heterogeneous oxidative desulfurization, which had a good dispersion of polyoxometalate ionic liquids. With the prepared materials, sulfur compounds
can be efficiently removed. Moreover, the oxidation product was analyzed by GC-MS to further investigate reaction mechanism.
A novel electrochemical DNA detection method based on bio-barcode/gold label silver stain dual amplification
Authors: Jiang Pengfei , Tan Miduo , Zhao Lan , Wang Yulin , Pan Ting , Chomba Haji , Huang Zhao , Chen Dongchu , Nie Libo
Published: January 2020

A novel electrochemical gene detection method based on bio-barcode/gold label silver stain (GLSS) dual amplification is presented. The silica nanoparticle/gold nanoparticles (SiO2/AuNPs) barcode probes were constructed by combining SiO2 nanoparticle-labeled DNA
with AuNPs, which hybridizes with target DNAs and the electrode surface-modified DNA probes. The silver ions were reduced on the surface of AuNPs to form a silver shell by the catalysis of AuNPs, and then the electrochemical detection of deposited silver was performed by linear sweep voltammetry
(LSV). In this paper, the effects of electrode blocking agent, blocking time and silver deposition time on electrochemical detection were also investigated. The proposed electrochemical DNA biosensor bring forth a low detection limit of 0.23 fM and a widely linear range of 1 fM to 10 pM. This
method can clearly distinguish the complementary and mismatched DNA, with good repeatability and stability.
Correlation of neuropeptides substance P and neuropeptide Y and their receptors with fracture healing in rats
Authors: Zou Zhenlv , Mei Gang , Tang Liying , Xu Yafei , Liu Jun , Wang Shangchong , Fu Su , Wu Jianqun , Liang Guoguang
Published: January 2020

Bone fracture healing is a complex process involving a cascade of cellular and molecular events that are orchestrated by a variety of factors, including neuropeptides and their receptors. However, the roles of neuropeptides and their receptors in the fracture healing process are controversial.
We monitored the expression and distribution of the neuropeptides, substance P (SP) and neuropeptide Y (NPY) and their receptors, neurokinin 1 receptor (NK1) and neuropeptide Y1 receptor (NPY1R), in rats undergoing fracture healing. Total RNA was extracted using Fe3O4
and was retrieved into DNA using the MagBeads Total RNA Extraction Kit. The expression levels of SP, NK1, and NPY at each time point in the healing bone tissue were found to be higher than the levels in normal bone tissue. Their location and expression levels correlated with the healing process.
In the callus formation stage, the expression levels of SP, NK1, and NPY were found to be increased in the matrix of the cartilage, in chondrocytes, and in the subperiosteal region. At the bone remodeling stage, they were located in the periosteum, new bone tissue, and perivascular regions,
and their expression levels gradually reduced. Therefore, we conclude that SP was involved in callus formation and bone resorption at different physiological concentrations. At some concentrations, SP positively regulated new bone formation via NK1. At other concentrations, the SP-NK1 interaction
promoted bone resorption. Very low expression levels of NPY1R were observed at the early healing stage, but they increased at the middle stage and then decreased at the late stage. This indicated that NPY was involved in bone formation through NPY1R-unrelated mechanisms. NPY1R was more involved
at the later stage of bone remodeling, according to its expression levels. NPY1R contributed to callus formation and remodeling.
Preparation and Electrochemical Properties of Multi-Walled Carbon Nanotube/Dextran/Nano-Gold Composites
Authors: Zhao Xin , Peng Xiarong , Zhao Tingkai , Yang Lei , Shu Yuan
Published: January 2020

Multi-walled carbon nanotube (MWCNT)/dextran/nano-gold composite was prepared by chemical solution reaction. The average diameter of gold nanoparticles was around 15 nm. MWCNT/dextran/nano-gold composites were uniformly dispersed in aqueous solution as electrode materials. MWCNT/dextran/nano-gold
composites exhibited excellent electrochemical property in [Fe(CN)6]3– /4– solution. Experimental results showed that the MWCNT/dextran/nano-gold composites with 50% MWCNTs presented obvious redox peak and low impedance and had good electrochemical response
to Cu2+. The redox peak currents were linear while the concentration of copper ions ranged from 1× 10–2 to 1 × 10–4 M. The relationship between oxidation peak currents I (A) and Cu2+ concentration C (M) was: ipk
(A) = 2.6207 × 10–6 + 43.91572 × 10–4 × C (M), and the limit of determination (LOD) of Cu2+ was 0.63 × 10–6 M, and linear coefficient was 0.9923.
Vanadium-Decorated Nickel Oxide Nanosheets for Photocatalytic Removal of Malachite Green Dye Using Visible Light
Authors: Basaleh A. S.
Published: January 2020

Nickel oxide (NiO) nanosheets were prepared using a hydrothermal method, and vanadiumdecorated nickel oxide nanosheets were prepared using a photoassisted deposition method. The NiO and vanadium-decorated nickel oxide (V @ NiO) photocatalysts were investigated by several techniques,
including BET, XPS, PL, UV-Vis, XRD, and TEM. The results demonstrated that the NiO bandgap energy can be adjusted by adjusting the weight percent of decorated vanadium. Malachite green dye degradation under visible light conditions was chosen to measure the photocatalytic performance of the
NiO and V @ NiO samples. Additionally, parameters that affect photocatalytic performance, such as the concentration of malachite green dye, dose of the photocatalyst and vanadium weight percent, were studied in detail. The outcomes reveal that V @ NiO samples have photocatalytic activity higher
than that of NiO samples due to their ability to hinder the electron–hole recombination rate and decrease the band gap energy.