bluuebunny/crossref_metadata_2025 huggingface dataset:
An Oxidative Stress Index‐Based Score for Prognostic Prediction in Colorectal Cancer Patients Undergoing Surgery
Authors: Cao Yinghao , Deng Shenghe , Yan Lizhao , Gu Junnan , Mao Fuwei , Xue Yifan , Zheng Changmin , Yang Ming , Liu Hongli , Liu Li , Liu Qian , Cai Kailin
Published: January 2021

Oxidative stress plays an important role in the development of colorectal cancer (CRC). This study is aimed at developing and validating a novel scoring system, based on oxidative stress indexes, for prognostic prediction in CRC patients. A retrospective analysis of 1422 CRC patients who underwent surgical resection between January 2013 and December 2017 was performed. These patients were randomly assigned to the training set (n = 1022) or the validation set (n = 400). Cox regression model was used to analyze the laboratory parameters. The CRC‐Integrated Oxidative Stress Score (CIOSS) was developed from albumin (ALB), direct bilirubin (DBIL), and blood urea nitrogen (BUN), which were significantly associated with survival in CRC patients. Furthermore, a survival nomogram was generated by combining the CIOSS with other beneficial clinical characteristics. The CIOSS generated was as follows: 0.074 × albumin (g/L), −0.094 × bilirubin (μmol/L), and ‐0.099 × blood urea nitrogen (mmol/L), based on the multivariable Cox regression analysis. Using 50% (0.1025) and 85% (0.481) of CIOSS as cutoff values, three prognostically distinct groups were formed. Patients with high CIOSS experienced worse overall survival (OS) (hazard ratio [HR] = 4.33; 95% confidence interval [CI], 2.80‐6.68; P < 0.001) and worse disease‐free survival (DFS) (HR = 3.02; 95% CI, 1.96‐4.64; P < 0.001) compared to those with low CIOSS. This predictive nomogram had good calibration and discrimination. ROC analyses showed that the CIOSS possessed excellent performance (AUC = 0.818) in predicting DFS. The AUC of the OS nomogram based on CIOSS, TNM stage, T stage, and chemotherapy was 0.812, while that of the DFS nomogram based on CIOSS, T stage, and TNM stage was 0.855. Decision curve analysis showed that these two prediction models were clinically useful. CIOSS is a CRC‐specific prognostic index based on the combination of available oxidative stress indexes. High CIOSS is a powerful indicator of poor prognosis. The CIOSS also showed better predictive performance compared to TNM stage in CRC patients.
Connection between the Altered HDL Antioxidant and Anti‐Inflammatory Properties and the Risk to Develop Alzheimer’s Disease: A Narrative Review
Authors: Zimetti Francesca , Adorni Maria Pia , Marsillach Judit , Marchi Cinzia , Trentini Alessandro , Valacchi Giuseppe , Cervellati Carlo
Published: January 2021

The protein composition of high‐density lipoprotein (HDL) is extremely fluid. The quantity and quality of protein constituents drive the multiple biological functions of these lipoproteins, which include the ability to contrast atherogenesis, sustained inflammation, and toxic effects of reactive species. Several diseases where inflammation and oxidative stress participate in the pathogenetic process are characterized by perturbation in the HDL proteome. This change inevitably affects the functionality of the lipoprotein. An enlightening example in this frame comes from the literature on Alzheimer’s disease (AD). Growing lines of epidemiological evidence suggest that loss of HDL‐associated proteins, such as lipoprotein phospholipase A2 (Lp‐PLA2), glutathione peroxidase‐3 (GPx‐3), and paraoxonase‐1 and paraoxonase‐3 (PON1, PON3), may be a feature of AD, even at the early stage. Moreover, the decrease in these enzymes with antioxidant/defensive action appears to be accompanied by a parallel increase of prooxidant and proinflammatory mediators, in particular myeloperoxidase (MPO) and serum amyloid A (SAA). This type of derangement of balance between two opposite forces makes HDL dysfunctional, i.e., unable to exert its “natural” vasculoprotective property. In this review, we summarized and critically analyzed the most significant findings linking HDL accessory proteins and AD. We also discuss the most convincing hypothesis explaining the mechanism by which an observed systemic occurrence may have repercussions in the brain.
Nonalcoholic Fatty Liver Disease and Cardiovascular Diseases: The Heart of the Matter
Authors: Chiriac Stefan , Stanciu Carol , Girleanu Irina , Cojocariu Camelia , Sfarti Catalin , Singeap Ana-Maria , Cuciureanu Tudor , Huiban Laura , Muzica Cristina Maria , Zenovia Sebastian , Nastasa Robert , Trifan Anca
Published: January 2021

Nonalcoholic fatty liver disease (NAFLD) has emerged as the most frequent cause of liver disease worldwide, comprising a plethora of conditions, ranging from steatosis to end-stage liver disease. Cardiovascular disease (CVD) has been associated with NAFLD and CVD-related events represent the main cause of death in patients with NAFLD, surpassing liver-related mortality. This association is not surprising as NAFLD has been considered a part of the metabolic syndrome and has been related to numerous CVD risk factors, namely, insulin resistance, abdominal obesity, dyslipidemia, hyperuricemia, chronic kidney disease, and type 2 diabetes. Moreover, both NAFLD and CVD present similar pathophysiological mechanisms, such as increased visceral adiposity, altered lipid metabolism, increased oxidative stress, and systemic inflammation that could explain their association. Whether NAFLD increases the risk for CVD or these diagnostic entities represent distinct manifestations of the metabolic syndrome has not yet been clarified. This review focuses on the relation between NAFLD and the spectrum of CVD, considering the pathophysiological mechanisms, risk factors, current evidence, and future directions.
Full-Field Displacement Measurements of Helicopter Rotor Blades Using Stereophotogrammetry
Authors: Zuo Chenglin , Wei Chunhua , Ma Jun , Yue Tingrui , Liu Lei , Shi Zheyu
Published: January 2021

This study presents a stereophotogrammetry approach to achieve full-field displacement measurements of helicopter rotor blades. The method is demonstrated in the wind tunnel test of a 2 m diameter rotor, conducted at the

5.5
 
m
×
4
 
m

Aeroacoustic Wind Tunnel of China Aerodynamics Research and Development Center (CARDC). By arranging the retroreflective targets on the special hat installed directly above the rotor hub, the dynamic motion of the rotor shaft was tracked accurately, and a unified coordinate system was established on the rotor. Therefore, three-dimensional coordinates of instantaneously measured targets attached on the blade could be transformed to the unified rotor coordinate system, thereby providing a basis for consistently calculating the blade displacements at different test conditions. Moreover, location deviations of the blade caused by the vibration of the measuring system or the rotor due to freestream and rotor rotation were also effectively corrected through coordinate transformation. Comparisons of experimental and simulation results for a range of hover and forward flight conditions show good magnitude and trend agreements.
A Study on the Therapeutic Efficacy of San Zi Yang Qin Decoction for Non-Alcoholic Fatty Liver Disease and the Underlying Mechanism Based on Network Pharmacology
Authors: Li Yiping , Liu Yang , Yang Ming , Wang Qianlei , Zheng Yu , Xu Jiaoya , Zheng Peiyong , Song Haiyan
Published: January 2021

Objective. This study aims to explore the therapeutic efficacy of San Zi Yang Qin Decoction (SZ) and its potential mechanism in the treatment of non-alcoholic fatty liver disease (NAFLD) based on network pharmacology and in vivo experiments. Methods. Effective chemicals and targets of SZ were searched in online databases, according to the drug-likeness of compounds and the binomial distribution of targets. A disease-target-chemical network was established using NAFLD-associated genes screened through GeneCards database, Gene Ontology (GO) terms, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Furthermore, animal experiments were conducted to verify the efficacy and mechanism of SZ predicted by network pharmacology. The NAFLD mouse model was established with C57BL/6J mice fed with a high-fat diet for 22 weeks. The mice in the control group were fed with a chow diet. From the 23rd week, the NAFLD mice were treated with intragastric SZ or normal saline for 8 weeks. After the glucose tolerance was measured, the mice were sacrificed, followed by the collection of serum and liver tissues. Pathological changes in liver tissues were examined by H&E staining. Additionally, alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum fast blood glucose, and insulin levels were detected. Expression levels of TNF-α of serum and liver tissues were determined by ELISA and qRT-PCR, respectively. Western blot was used to detect the activation of AKT in liver tissues. Results. A total of 27 effective compounds and 20 targets of SZ were screened. GO analysis uncovered a significant correlation between the targets of SZ and those of NAFLD. KEGG analysis presented the signaling pathways enriched in SZ and NAFLD, including NAFLD, TNF-α, and apoptosis pathways. The area under the curve of major GO and KEGG pathways indicated the potential role of SZ in improving NAFLD. In vivo experiments demonstrated that SZ significantly alleviated hepatosteatosis and inflammatory cell infiltration in liver tissues, reduced serum transaminases, and improved insulin resistance and glucose tolerance of NAFLD mice. The protein level of phospho-AKT was upregulated by SZ. Additionally, SZ treatment obviously impaired the TNF-α level in the serum and liver tissue of NAFLD mice. Conclusions. According to the network pharmacology analysis and in vivo experiments, SZ could have therapeutic efficacy for NALFD. The mechanism mainly involves pathways relative to insulin resistance, TNF-α, and apoptosis. Our results provide a scientific basis for SZ in the clinical treatment of NAFLD.
Research on the Relationship between Business Cycle and Industrial Fluctuations in Northeast China Based on Complete Ensemble Empirical Mode Decomposition with Adaptive Noise
Authors: Zhou Yinan , Gu Guofeng , Ren Qiushuang
Published: January 2021

The Chinese economy has developed rapidly since the reform and opening up, but economic growth in Northeast China has declined dramatically after the 21st century. In this context, exploring the characteristics of economic and industrial fluctuations in the northeast of China and their relationship is beneficial to alleviating economic fluctuations and promoting stable economic development from the perspective of industrial development. The relationship between economic and industrial fluctuations in the three provinces of Northeast China was reexamined from the angle of fluctuation components with the complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN) algorithm. The results obtained are as follows: (1) In the three northeastern provinces of China, economic fluctuations were almost free from the influence of the primary industry, most affected by the secondary industry, and gradually influenced by the tertiary industry after the 21st century. (2) Regarding the short‐term business cycle of each province, economic development was the most stable when the market and government participated in the development of the secondary industry simultaneously. (3) The midterm business cycle of Jilin Province was affected by the investment of equipment in secondary and tertiary industries, while that of Liaoning Province was affected by the investment of equipment in the secondary industry. (4) Investment in the equipment of the secondary industry and the construction of secondary and tertiary industries was the key to maintaining the stability of long‐term business cycle in Heilongjiang Province, and that in the construction of secondary and tertiary industries was the key to maintaining the stability of long‐term business cycles in Jilin and Liaoning Provinces.
COVID-19-Associated Multisystem Inflammatory Syndrome Complicated with Giant Coronary Artery Aneurysm
Authors: Navaeifar Mohammad Reza , Shahbaznejad Leila , Sadeghi Lotfabadi Ali , Rezai Mohammad Sadegh
Published: January 2021

In the early stages of the outbreak of the novel coronavirus disease 2019 (COVID-19), it was assumed that this infection is very mild and uncommon in children. However, recent reports have shown that children may also develop the disease and its severe complications. These complications included shock, multisystem inflammatory syndrome in children (MIS-C), and pneumonia in children. A previously healthy 14-month-old boy presented with fever, irritability, and skin rash, besides changes in the lips, conjunctiva, and tongue. His medical history, clinical presentations, treatment, laboratory data, and follow-up information were recorded. He was treated according to the diagnosis of Kawasaki disease (KD). He had a history of close contact with a COVID-19 patient. However, the result of reverse transcription-polymerase chain reaction (RT-PCR) assay for COVID-19 was negative. Immunoglobulin M for COVID-19 was positive (1.20), while immunoglobulin G was negative (0.37). Three weeks later, seroconversion of COVID-19 immunoglobulin G (1.42) occurred. Despite treatment with two doses of intravenous immunoglobulin and methylprednisolone, coronary artery ectasia was detected. On the sixth day of hospitalization, the patient experienced hypotension, which necessitated treatment with inotropic drugs and resulted in a change of diagnosis to MIS-C. The later echocardiography showed evidence of coronary artery aneurysm (CAA), which finally changed to giant CAA. Although the patient was treated with infliximab, the size of CAA showed a significant decrease in the one-month follow-up. This is the first report of MIS-C during the COVID-19 pandemic in Iran, accompanied by KD, which was complicated with giant CAA.
Collaborative Innovation Efficiency and Influencing Factors of Civil-Military Integration Enterprises
Authors: Wang Zilong , Zhang Zhiwen , Xu Xiaodi , Wang Dandan
Published: January 2021

Military-civilian integration has developed into a national strategy. It helps military technology transform into civilian consumer goods but also lets civilian suppliers join the military supply chain. Collaborative innovation is a good method to drive the development of civil-military integration. The measurement of the efficiency of military-civilian integration enterprises’ collaborative innovation and analysis of influencing factors are an important basis for making relevant policies. Thus, this paper builds up a two-stage StoNED model. It is used to measure the efficiency of collaborative innovation of civil-military integration enterprises. Then, the Tobit model is used to analyze the influencing factors of innovation efficiency. Here, we show that the overall efficiency and substages efficiency are relatively high, and the low efficiency of the technology R&D stage is the limiting factor for achieving the optimal overall efficiency. Our results demonstrate that there are differences in the effect of the same factor on efficiency in different substages.
Experimental Study on Fracture Patterns and Crack Propagation of Sandstone Based on Acoustic Emission
Authors: Wang Chuangye , Chang Xinke , Liu Yilin
Published: January 2021

To investigate the fracture pattern and crack propagation of rock under different stresses, Brazilian split tests, preset angle tests, and uniaxial compression acoustic emission (AE) tests were carried out on sandstone to obtain the mechanical parameters and AE signals of the whole test process. Based on the analysis of the distribution of the characteristic AE indicators rise time/amplitude (RA) and average frequency (AF) combined with the core definition of areal density, the test results showed the following. In Brazilian split tests and preset angle tests, shear fractures and tensile fractures accompanied the whole process of rock damage and failure, and the crack type reflected by the RA‐AF distribution was consistent with the theoretical analysis and actual failure results. The fracture pattern of sandstone under uniaxial compression was dominated by shear fracture, and tensile and shear cracks had the same evolutionary trend. In uniaxial compression, the development of cracks was complicated from the stage of steady development of microcracks, and the crack development was different in different specimens, which eventually leads to different failure modes. That is, the failure mode of sandstone could provide positive feedback to the RA‐AF distribution. Under different stresses, the characteristics of the cumulative event rate of tensile or shear fractures varied significantly among stages, which corresponded to the various stages of rock damage and deformation.
Enteropathogenic Infections: Organoids Go Bacterial
Authors: Hentschel Viktoria , Arnold Frank , Seufferlein Thomas , Azoitei Ninel , Kleger Alexander , Müller Martin
Published: January 2021

Enteric infections represent a major health care challenge which is particularly prevalent in countries with restricted access to clean water and sanitation and lacking personal hygiene precautions, altogether facilitating fecal-oral transmission of a heterogeneous spectrum of enteropathogenic microorganisms. Among these, bacterial species are responsible for a considerable proportion of illnesses, hospitalizations, and fatal cases, all of which have been continuously contributing to ignite researchers’ interest in further exploring their individual pathogenicity. Beyond the universally accepted animal models, intestinal organoids are increasingly valued for their ability to mimic key architectural and physiologic features of the native intestinal mucosa. As a consequence, they are regarded as the most versatile and naturalistic in vitro model of the gut, allowing monitoring of adherence, invasion, intracellular trafficking, and propagation as well as repurposing components of the host cell equipment. At the same time, infected intestinal organoids allow close characterization of the host epithelium’s immune response to enteropathogens. In this review, (i) we provide a profound update on intestinal organoid-based tissue engineering, (ii) we report the latest pathophysiological findings defining the infected intestinal organoids, and (iii) we discuss the advantages and limitations of this in vitro model.
Association of Bone Metabolism Indices and Bone Mineral Density with Diabetic Retinopathy in Elderly Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Inpatient Study in China
Authors: Zhao Xin , Huo Lili , Yu Xiaofeng , Zhang Xiaomei
Published: January 2021

Objective. This study is aimed at analyzing the association between bone metabolism indices and diabetic retinopathy (DR) in elderly patients with type 2 diabetes mellitus. Methods. Data of 352 men and 284 postmenopausal women, aged more than 50 years, with type 2 diabetes mellitus were retrospectively analyzed. Patients were divided into three groups based on the degree of DR: nondiabetic retinopathy (NDR) group, background diabetic retinopathy (BDR) group, and proliferative diabetic retinopathy (PDR) group. Results. (1) The diabetic duration and urinary albumin to creatinine ratio (UACR) were significantly higher in the PDR and BDR groups than in the NDR group (

P
<
0.05

). The level of beta-C-terminal telopeptide (β-CTX) in male patients was lower in the PDR and BDR groups than in the NDR group (

P
<
0.05

). In addition, the level of procollagen 1 intact N-terminal (P1NP) in female patients was higher in the PDR and BDR groups than in the NDR group (

P
<
0.05

). (2) For men and postmenopausal women, the proportion of vitamin deficiency was higher in the PDR and BDR groups than in the NDR group (

P
<
0.05

). (3) The logistic regression analysis in men and postmenopausal women showed that the diabetic duration and lower levels of UACR and 25(OH)D were independent risk factors for DR (

P
<
0.05

). (4) The diabetic duration was also an independent risk factor for PDR (

P
<
0.05

); however, no independent correlation was found between the level of 25(OH)D and PDR (

P
>
0.05

). Conclusions. A close association was observed between 25(OH)D level and DR in the elderly male patients and postmenopausal women with type 2 diabetes mellitus. P1NP and β-CTX levels might be closely related to DR in elderly male patients and postmenopausal women with type 2 diabetes mellitus.
Rivaroxaban: Expanded Role in Cardiovascular Disease Management—A Literature Review
Authors: Ajmal Muhammad , Friedman Jacob , Sipra Qurat Ul Ain Riaz , Lassar Tom
Published: January 2021

Direct oral anticoagulants (DOACs) are widely used for the prevention of stroke in nonvalvular atrial fibrillation, treatment of deep venous thrombosis and pulmonary embolism, and as prophylaxis after hip and knee surgery after approval by the Food and Drug Administration. In the last decade, DOACs were studied for various indications; this review is focused on rivaroxaban, a factor Xa inhibitor, which is used in an expanded evidence-based fashion for coronary artery disease, peripheral artery disease, heart failure, malignancy, and prophylaxis of deep venous thrombosis in acute medical illnesses.
New Exact Traveling Wave Solutions of the Time Fractional Complex Ginzburg-Landau Equation via the Conformable Fractional Derivative
Authors: Li Zhao , Han Tianyong
Published: January 2021

In this study, the exact traveling wave solutions of the time fractional complex Ginzburg-Landau equation with the Kerr law and dual-power law nonlinearity are studied. The nonlinear fractional partial differential equations are converted to a nonlinear ordinary differential equation via a traveling wave transformation in the sense of conformable fractional derivatives. A range of solutions, which include hyperbolic function solutions, trigonometric function solutions, and rational function solutions, is derived by utilizing the new extendedG′/G-expansion method. By selecting appropriate parameters of the solutions, numerical simulations are presented to explain further the propagation of optical pulses in optic fibers.
Automated Reconstruction of Parametric BIM for Bridge Based on Terrestrial Laser Scanning Data
Authors: Qin Guocheng , Zhou Yin , Hu Kaixin , Han Daguang , Ying Chunli
Published: January 2021

Building information modeling (BIM) in industrialized bridge construction is usually performed based on initial design information. Differences exist between the model of the structure and its actual geometric dimensions and features due to the manufacturing, transportation, hoisting, assembly, and load bearing of the structure. These variations affect the construction project handover and facility management. The solutions available at present entail the use of point clouds to reconstruct BIM. However, these solutions still encounter problems, such as the inability to obtain the actual geometric features of a bridge quickly and accurately. Moreover, the created BIM is nonparametric and cannot be dynamically adjusted. This paper proposes a fully automatic method of reconstructing parameterized BIM by using point clouds to address the abovementioned problems. An algorithm for bridge point cloud segmentation is developed; the algorithm can separate the bridge point cloud from the entire scanning scene and segment the unit structure point cloud. Another algorithm for extracting the geometric features of the bridge point cloud is also proposed; this algorithm is effective for partially missing point clouds. The feasibility of the proposed method is evaluated and verified using theoretical and actual bridge point clouds, respectively. The reconstruction quality of BIM is also evaluated visually and quantitatively, and the results show that the reconstructed BIM is accurate and reliable.
Stable High-Speed Quadrotor Flight using Differential Trajectory
Authors: Wu Ying , Xie Yun , Li Sen , Wang Depei
Published: January 2021

This paper addresses the trajectory tracking control issue of a quadrotor with environmental disturbances, which particularly focuses on attitude correction during flight and response speed improvement. In this paper, the proposed control method uses the differential equation to transform the desired trajectory for improving the robustness of a quadrotor during high-speed flight. Meanwhile, a nonlinear controller based on the rotation matrix is designed to avoid singularities of Euler angles. The controller can also stabilize the position error to zero without reducing the control thrust when the attitude error is large. Finally, we conduct simulations on a tethered quadrotor to achieve high-speed flight in limited space. The simulation results show that the control method can stabilize a quadrotor at high-speed trajectory flight and keep a quadrotor stable when it is disturbed by aerodynamic drag and mass change.
A Para-Bombay Blood Group Case Associated with a Novel FUT1 Mutation c.361G>A
Authors: Lei Hang , Shen Yuqing , Wang Yuqing , Su Naizhu , Wang Xuefeng , Cai Xiaohong
Published: January 2021

Background: Here we report a case of para-Bombay phenotype due to a novel mutation FUT1 c.361G>A p.(Ala121Thr) and a nonfunctional allele FUT1*01N.13(c.881_882delTT) which showed a discrepancy in the routine ABO blood group typing. Materials and Methods: The ABO phenotype and the Lewis blood group were typed with serological methods. The ABH antigens in saliva were determined by a hemagglutination inhibition test. The CDS region of ABO, FUT1and FUT2 were amplified with polymerase chain reaction and then directly sequenced. The novel mutation was confirmed by cloning and sequencing. Three-dimensional (3-D) structural analysis of the mutant and wild-type Fut1 were performed by the Chimera software. Results: A, B and H antigens were not detected on the surface of red blood cells (RBCs) by the serological technique, and the B and H blood group substances were detected in the saliva, while the Lewis phenotype was Le(a–b+). Sequencing and cloning analysis showed the presence of a novel FUT1 mutation c.361G>A and a nonfunctional allele FUT1*01N.13(c.881_882delTT). The ABO genotype was ABO*B.01/ABO*O.01.01. The in silico analysis showed that the mutation p.(Ala121Thr) of FUT1did not change the 3-D structure of the whole enzyme but caused a certain amplitude of turnover in the loop region where Ala121 was located. Conclusions: A novel FUT1 allele (FUT1*c.361G>A) was identiﬁed in a Chinese individual with para-Bombay B phenotype. The FUT1c.361G>A mutation may significantly downregulate the expression of H antigens on RBCs by damaging the enzyme conformation.
Editorial
Authors: Castro Filho Cláudio Marcondes de , Sabbag Deise Maria Antonio
Published: January 2021

InCID: Revista de Ciência da Informação e Documentação, Ribeirão Preto, v. 11, n. 2, set. 2020/fev. 2021.
Fontes orais e sua relevância documental para as narrativas de memória nas organizações
Authors: Cortes Vanderléa Nobrega de Azevedo , Bari Valéria Aparecida , Belchior Cleide Aparecida Freires
Published: January 2021

Dialogando com a evolução da Ciência da Informação (CI) e suas relações histórico-sociais entre Biblioteconomia e Documentação, que tem sido amplamente explorada sem delimitar fronteiras do saber e campo de atuação dos profissionais da área, este artigo envolve considerações que se entrelaçam entre as fontes orais e sua relevância documental para as narrativas de memória no âmbito das organizações. Através de uma pesquisa de revisão narrativa de literatura, teve por objetivo identificar como as fontes orais podem preencher as lacunas documentais no âmbito das organizações através das narrativas de memória. Compõe um cenário de discussões contemporâneas embasado por um referencial teórico que destaca a gestão documental e suas possibilidades de reconhecer as fontes orais como fonte documental de recuperação da informação. Aborda a relação do arquivo e da gestão documental expandindo as bases teóricas por diversos autores que permeiam pela interdisciplinaridade dos conceitos da memória, destacando autores clássicos como Jacques Le Gof (1990), Maurice Halbwachs (1990) e Pierre Nora (1993), aproximando-os aos diálogos contemporâneos que exploram as narrativas de memória como estratégia de comunicação e da memória institucional, a saber: Icleía Thiessen (2013), Karen Worcman (2004) e Rodrigo Cogo (2016) vinculando ainda a relação indissociável dos arquivos com a memória defendida por Almeida (2017), Barros e Amélia (2009). Destaca o poder da informação face as mudanças tecnológicas da sociedade do conhecimento que através dos documentos, monumentos e na oralidade supera a objetividade dos fatos e conclui que as fontes orais compõem parte essencial para preencher as lacunas documentais existentes, acrescentando que o resgate da memória institucional promove a compreensão do presente como elemento norteador para o futuro da organização, sendo importante destacar que a memória institucional é a amplitude de documentos, monumentos e oralidade.
A classificação e o acesso à informação em Moçambique
Authors: Macie Gildo Carlos , Cabsela Cecília Preciosa , Nharreluga Rafael Simone
Published: January 2021

Este artigo, de natureza qualitativa em sua abordagem, tem como objetivo analisar a situação arquivística em Moçambique, a partir do cruzamento da prática arquivística exercida nas instituições da administração pública – ênfase na classificação arquivística – com a classificação das informações referida no âmbito da legislação sobre o direito à informação, com destaque para a Lei do Direito à Informação e demais instrumentos legais com ela conjugados, contrapondo o sigilo em relação ao acesso à informação. Buscou-se um referencial teórico, cujo desenvolvimento baseou-se no conceito de gestão de documentos para extrair a ideia de organização de documentos, numa articulação com a matriz histórica do acesso à informação que relativiza o sigilo. Constatou-se o desenquadramento da prática arquivística em curso nas instituições da administração pública, em decorrência da falta de integração da dimensão profissional da arquivística nas diversas atividades e do sigilo impregnado na legislação sobre o direito à informação ou a ela relacionada. Conclui-se que somente a introdução de medidas de redução ou superação do caráter absoluto do sigilo em relação ao acesso à informação e de profissionalização e regulamentação da área dos arquivos em Moçambique poderá ultrapassar o problema.
Análise da literatura sobre a temática "Gestão de dados" no âmbito da Ciência da Informação
Authors: Costa Levi Cadmiel Amaral da , Sousa Marckson Roberto Ferreira de
Published: January 2021

Objetiva analisar a literatura nacional da área da Ciência da Informação acerca do tema "Gestão de Dados" no período compreendido entre 2015 e 2019. Para tanto, realizou-se uma pesquisa de abordagem quantitativa, descritiva e, no que diz respeito aos procedimentos técnicos, trata-se de uma análise de redes de pesquisa. Buscou-se por estudos que trataram da temática supracitada na Base de Dados Referencial de Artigos de Periódicos em Ciência da Informação (BRAPCI). A partir dos procedimentos de busca, foram selecionados 29 artigos, os quais foram utilizados para geração e análise de três redes distintas, a saber: rede de palavras-chave, rede de co-autoria e rede institucional. Os resultados apresentam um total de 97 palavras-chave utilizadas nos estudos selecionados, por meio da colaboração de 58 pesquisadores e afiliados a 22 instituições distintas, o que nos permite concluir que o tema "Gestão de Dados" tem sido tratado na Ciência da Informação por meio de relações com diversas questões, a saber: ciência aberta, preservação digital, repositórios de dados, dentre outros. Conclui-se, além disto, que a maioria dos estudos foram desenvolvidos em co-autoria e que as relações institucionais ultrapassam limites estaduais, regionais e nacionais.
Facile Ultrasound-Triggered Release of Calcein and Doxorubicin from Iron-Based Metal-Organic Frameworks
Authors: Ibrahim Mihad , Sabouni Rana , Husseini Ghaleb A. , Karami Abdollah , Bai Renu Geetha , Mukhopadhyay Debasmita
Published: January 2021

Metal-organic frameworks (MOFs) are promising new nanocarriers with potential use in anticancer drug delivery. However, there is a scarcity of studies on the uptake and release of guest molecules associated with MOF nanovehicles, and their mechanism is poorly understood. In this work,
newly developed iron-based MOFs, namely Fe-NDC nanorods, were investigated as potential nanocarriers for calcein (as a model drug/dye) and Doxorubicin (a chemotherapeutic drug (DOX)). Calcein was successfully loaded by equilibrating its solution with the MOFs nanoparticles under constant stirring.
The calcein average encapsulation efficiency achieved was 43.13%, with a corresponding capacity of 17.74 wt.%. In-vitro calcein release was then carried out at 37°C in phosphate buffer saline (PBS) using ultrasound (US) as an external trigger. MOFs released an average of 17.8% (without
US), whereas they released up to 95.2% of their contents when 40-kHz US at ~1 W/cm2 was applied for 10 min. The Cytotoxic drug DOX was also encapsulated in Fe-NDC, and its In-vitro release profile was determined under the same conditions. DOX encapsulation efficiency and capacity
were found to be 16.10% and 13.37 wt.%, respectively. In-vitro release experiments demonstrated significant release, reaching 80% in 245 minutes, under acoustic irradiation, compared to around 6% in the absence of US. Additionally, experimental results showed that Fe-NDC nanoparticles
are biocompatible even at relatively high concentrations, with an MCF-7 IC50 of 1022 g/ml. Our work provides a promising platform for anticancer drug delivery by utilizing biocompatible Fe-NDC nanoparticles and US as an external trigger mechanism.
Nanoencapsulation of Andrographolide Rich Extract for the Inhibition of Cervical and Neuroblastoma Cancer Cells
Authors: Sanati Parisa , Chua Lee Suan , Nasiri Rozita , Hashemi Seyedeh-Sara
Published: January 2021

Andrographis paniculata is traditionally used for many diseases and scientifically proven for anti-cancer property. Andrographolide which is the marker compound is believed to be the main contributor to the pharmacological activities. The poor solubility and bioavailability of this
diterpenoid lactone could be overcome by nanoencapsulation. Reflux extraction, and followed by successive Soxhlet fractionation were used to obtain andrographolide rich extract from the herb. Spontaneous emulsion solvent diffusion was used to nanoencapsulate andrographolide using poly(lactic-co-glycolic
acid) with 1% polyvinyl alcohol as emulsifier. Nanospheres loaded with andrographolide was found to have the particle size, 163 nm; polydispersity index, 0.26 and zeta potential, – 57.85 mV. The encapsulation efficiency and in vitro drug release were 80.0% and 84.2%, respectively. The
andrographolide nanoparticles could inhibit the proliferation of cervical and neuroblastoma cells with no adverse effect on normal human skin cells. Andrographolide rich extract loaded nanoparticles could inhibit the proliferation of HeLa and SH-SY5Y cells, mainly through Bax-induced apoptosis.
The result was consistent with the low expression of anti-apoptotic genes (Bcl-2 and Bcl-xL) and prognostic factor (Ki-67). The tumour size of HeLa bearing mice was significantly reduced (73%) after treated with andrographolide rich nanoparticles (10 mg/kg body weight) for a month.
Near-Infrared Light Laser-Triggered Release of Doxorubicin and Sorafenib from TemperatureSensitive Liposomes for Synergistic Therapy of Hepatocellular Carcinoma
Authors: Peng Yuan , Su Zhenwei , Wang Xin , Wu Teng , Xiao Hong , Shuai Xintao , Lan Yue
Published: January 2021

Chemotherapy of hepatocellular carcinoma (HCC) is facing drug resistance, which leads to unsatisfactory therapeutic effect. Thus, a combination therapy using multiple drugs may overcome this challenge. The current study aims to realize a synergistic chemotherapy of HCC by using a near-infrared
light (NIR) responsive nanocarrier to co-deliver the chemotherapeutic drug Doxorubicin (DOX) and molecular targeting agent Sorafenib (SF). The nanocarrier, which could effectively load DOX in its aqueous core while SF and IR-780 in its lipid bilayer, is fabricated from a temperature-sensitive
liposome (TSL) modified with PF127. An efficient SF and DOX co-loading was achieved, and meanwhile the effective photothermal conversion of IR-780 under NIR laser may cause a disassembly of the liposome structure which may trigger a rapid drug release in tumor site, greatly boosting the synergetic
chemotherapeutic effect. The NIR laser-triggered drug release and the synergistic anti-tumor effect were evaluated both in cell and animal experiments, which revealed that the PF127-modified TSL is a potent nanoplatform to improve the HCC treatment through co-delivering a drug combination.
Tumor Microenvironment-Specific Functional Nanomaterials for Biomedical Applications
Authors: Zhao Linlu , Liu Heng , Xing Yanlong , Wang Rui , Cheng Ziyi , Lv Chuanzhu , Lv Zhiyue , Yu Fabiao
Published: January 2021

In recent years, considerable achievements have been made to motivate the construction of tumor microenvironment (TME)-specific functional nanomaterials, which can effectively respond to the inherent pathological and physicochemical conditions in diseased regions to improve the specificity
of imaging and drug delivery. Until now, various nanoarchitectures have been designed to combat cancer effectively and specifically. This review summarizes the latest developments in TME-specific theranostic nanoplatforms based on multifunctional nanomaterials that hold potential for achieving
the targeted recognition at tumor sites. Recent progress and achievements have also been summarized for nanosystems that can specifically respond to the TME with various stimulus-responsive strategies and their applications for drug delivery, diagnosis, treatment, and synergistic theranostics
of cancer. This review emphasizes the significance of functional nanomaterials in response to tumor stimuli to enhance anticancer treatment efficiency and facilitate development in extensive research fields, including nanoscience, biomedicine, and clinical applications.
Mechanism of Action of Periplogenin on Nasopharyngeal Carcinoma Based on Network Pharmacology and Experimental Study of Vitamin E Coupled with Periplogenin Self-Assembled Nano-Prodrug for Nasopharyngeal Carcinoma
Authors: Ye Huixin , Wei Xianfu , Meng Chengxing , Wei Yuanyu , Liang Guangzhao , Huang Zhengquan , Guo Ling , Su Wenwen
Published: January 2021

Periplogenin is a compound extracted from cortex periplocae. In the monomers' screening for inhibiting nasopharyngeal carcinoma, we found that periplogenin can inhibit nasopharyngeal carcinoma; however, its mechanism is still unclear. In this study, the chemical structure of periplogenin
was uploaded to the PubChem database in order to obtain the target of periplogenin. The NPC's differential genes were obtained by analyzing the nasopharyngeal carcinoma data in the GEO database by R software. The common target of periplogenin and nasopharyngeal carcinoma was obtained through
Cytoscape. Through R software analysis, ALB, epidermal growth factor receptor (EGFR), MAPK1, ESR1, MAPK8, SRC, CASP3, HSP90AA1, AR, MAPK14 may be the main targets of periplogenin in NPC. Through go enrichment analysis, it was found that periplogenin acted mainly on nasopharyngeal carcinoma
through response to steroid metabolic process, cellular response to steroid hormone stimulus, hormone-mediated, and steroid hormone signaling pathway. After enrichment analysis on the Kyoto Encyclopedia of Genes and Genomes pathway, it was found that periplocan may inhibit NPC through the
MAPK signaling pathway (the main signaling pathway), and the signaling pathway of proteoglycans in cancer, and the PI3K/AKT signaling pathway as well. In this study, we also carried out the experimental study of vitamin E together with periplogenin self-assembled nano-prodrugs in the treatment
of NPC, and the results showed that tumor weight of PBS group was 0.531±0.039 g, while that of PPG group and MPSSV-NPs group was 0.258±0.059 g and 0.169±0.033 g, respectively, which was lower than PBS group. And the tumor inhibition rate of MPSSV-NPs was 69.41%, which
was significantly higher than that of the PPG group (51.38%). This study demonstrated the mechanism of inhibition of nasopharyngeal carcinoma (NPC) by the monomer of periplogenin based on network pharmacology. We preliminarily confirmed that vitamin E coupled with a periplogenin self-assembled
nano-prodrug has obvious effect in treating nasopharyngeal carcinoma.
Screening and Postoperative Evaluation of Breast Cancer Based on Serum Proteins Analysis Using Label-Free Surface-Enhanced Raman Spectroscopy Technology
Authors: Liu Xiaokun , Lin Xueliang , Huang Zongwei , Zhu Youzhi , Peng Min , Jia Xianggang , Weng Shuyun , Weng Youliang , Feng Shangyuan
Published: January 2021

Breast cancer is a malignant tumor of breast epithelial tissue. Early diagnosis and postoperative evaluation of breast cancer are critical to improve the survival rate. The current main screening methods are mammography and computerized tomography (CT), however, these methods suffer
from false positives, over-diagnosis and radiation risk. Herein, unlabeled surface-enhanced Raman spectroscopy (SERS) technology combined with silver nanoparticles that was used to measure and analyze peripheral serum protein samples from patients of breast cancer for preoperation, postoperation
and normal subjects. Results showed that there were significant differences in the serum protein SERS spectra among three groups due to changes in certain biochemical compositions related to breast cancer transformation. Moreover, diagnostic sensitivity, based on principal component analysis
combined with linear discriminant analysis (PCA-LDA) for pre-surgery versus post-surgery, post-surgery versus normal and pre-surgery versus normal were 96.7%, 53.3%, and 100%, respectively, and the diagnostic specificities were 96.7%, 46.7%, and 96.7%, respectively. Therefore, serum protein
SERS combined with PCA-LDA analysis holds promising potential as a novel strategy for early screening and postoperative evaluation of breast cancer.
Reliability of the Edinburgh Claudication Questionnaire for Identifying Symptomatic PAD in General Practice
Authors: Boylan Luke , Nesbitt Craig , Wilson Lesley , Allen John , Sims Andrew , Guri Ina , Mawson Philip , Oates Crispian , Stansby Gerard , Investigators On Behalf of the NOTEPAD
Published: January 2021

The Edinburgh Claudication Questionnaire (ECQ) was developed to help identify peripheral arterial disease (PAD) in the general population but has not been validated against diagnostic arterial imaging methods such as Duplex Vascular Ultrasound Scanning (DUS). In the present study, we assessed the accuracy of the ECQ for diagnosis using DUS. As part of a National Institute of Health Research funded project looking at novel diagnostic methods, 250 patients were studied from 15 general practices across North East England from May 2015 and November 2016. Practices identified those with a PAD diagnosis from their registers as well as age- and sex-matched controls. All the ECQs were recorded by a vascular specialist nurse. Duplex vascular ultrasound scanning was used as a reference standard for the diagnosis of occlusive PAD. The ECQ had a sensitivity of 52.5% (95% CI: 42.3%-62.5%), specificity of 87.1% (95% CI: 80.6%-92.0%), positive likelihood ratio of 4.06 (95% CI: 2.57-6.42), and negative likelihood ratio of 0.55 (95% CI: 0.44-0.68) compared with reference standard DUS. The ECQ has relatively poor overall diagnostic test accuracy in isolation. It may be helpful in ruling out PAD or as a supplementary test to improve diagnosis of symptomatic disease in General Practice.
Intravenous pamidronate for treatment of osteogenesis imperfecta in Indian children
Authors: Shah Ira , Goel Akshat , Shetty Naman S , Johari Ashok
Published: January 2021

Osteogenesis imperfecta is characterised by low bone mineral density, bone fragility, fractures and deformity. We present five such children treated with intravenous pamidronate, which resulted in a decrease of fracture rate and increase in spinal bone mineral density.
Artificial Intelligence in Toxicologic Pathology: Quantitative Evaluation of Compound-Induced Hepatocellular Hypertrophy in Rats
Authors: Pischon Hannah , Mason David , Lawrenz Bettina , Blanck Olivier , Frisk Anna-Lena , Schorsch Frederic , Bertani Valeria
Published: January 2021

Digital pathology evolved rapidly, enabling more systematic usage of image analysis and development of artificial intelligence (AI) applications. Here, combined AI models were developed to evaluate hepatocellular hypertrophy in rat liver, using commercial AI-based software on hematoxylin and eosin-stained whole slide images. In a first approach, deep learning-based identification of critical tissue zones (centrilobular, midzonal, and periportal) enabled evaluation of region-specific cell size. Mean cytoplasmic area of hepatocytes was calculated via several sequential algorithms including segmentation in microanatomical structures (separation of sinusoids and vessels from hepatocytes), nuclear detection, and area measurements. An increase in mean cytoplasmic area could be shown in groups given phenobarbital, known to induce hepatocellular hypertrophy when compared to control groups, in multiple studies. Quantitative results correlated with the gold standard: observation and grading performed by board-certified veterinary pathologists, liver weights, and gene expression. Furthermore, as a second approach, we introduce for the first time deep learning-based direct detection of hepatocellular hypertrophy with similar results. Cell hypertrophy is challenging to pick up, particularly in milder cases. Additional evaluation of mean cytoplasmic area or direct detection of hypertrophy, combined with histopathological observations and liver weights, is expected to increase accuracy and repeatability of diagnoses and grading by pathologists.
Standing by the promise: Acts of anticipation in Rio and Jakarta
Authors: Kemmer Laura , Simone AbdouMaliq
Published: January 2021

Cities are promising machines always holding out prospects for better lives, always attempting to guarantee that things will not remain the same and that whatever changes do ensue are for the better. We propose a notion of “promise” not as simply another descriptor in a long line of adjectives about the city. Rather, we argue that the urban institutional landscape constantly generates new promises as way of anticipation, which in turn allows residents to write themselves into select urban operations. This article engages two central districts in Rio de Janeiro and Jakarta to explore how residents “stand by” the promise, not of passive waiting, but as maneuvers of either staying tuned to or as way of tactical detachment from the multiple trajectories which have been conjured up in the here and now. We understand these maneuvers as acts of “minor” future making that rely upon practices and materials that may seem of little use, but which enable a process of incremental small adjustments and collective subversion of urban trajectories of the transitory.