bluuebunny/crossref_metadata_2025 huggingface dataset:
Prehabilitation Before Gastrointestinal Cancer Surgery: Protocol for an Implementation Study
Authors: Raso Kristy-Lee , Suen Michael , Turner Jane , Khatri Sonia , Lin Yanlan , Wildbore Carolyn , Becerril-Martinez Guillermo , Le Page Philip , Tan Sim Yee , Egger Sam , Vardy Janette
Published: November 2022

Background

Surgery remains the standard curative treatment for early-stage colorectal and upper gastrointestinal cancer. Reduced preoperative functional capacity, nutritional status, and psychological well-being are associated with poor postoperative outcomes. Prehabilitation aims to improve preoperative functional reserves through physical, nutritional, and psychological interventions. Yet, how it transitions from a trial setting to being integrated into a real-world health setting is unknown.

Objective

The primary aim is to evaluate the implementation of a multimodal (supervised exercise, nutrition, and nursing support) prehabilitation program into standard care for patients with gastrointestinal cancer (colorectal and upper gastrointestinal cancer) scheduled for curative intent surgery. The secondary aim is to determine the impact of a multimodal prehabilitation program on functional capacity, nutritional and psychological status, and surgical outcomes.

Methods

This is an implementation study that will investigate a multimodal prehabilitation intervention, in a nonblinded, nonrandomized, single-group, pre-post design. Patients diagnosed with colorectal and upper gastrointestinal cancer scheduled for potentially curative intent surgery at Concord Repatriation General Hospital, with ≥14 intervention days prior to surgery and are medically cleared to exercise will be eligible. The study will be evaluated using the Reach, Effectiveness, Adoption, Implementation, and Maintenance Evaluation Framework.

Results

The protocol was approved in December 2019 by the Concord Repatriation General Hospital Human Research Ethics Committee (reference number 2019/PID13679). Recruitment commenced in January 2020. In response to the COVID-19 pandemic, recruitment was paused in March 2020 and reopened in August 2020 with remote or telehealth intervention adaptations. Recruitment ended on December 31, 2021. Over the 16-month recruitment period, a total of 77 participants were recruited.

Conclusions

Prehabilitation represents an opportunity to maximize functional capacity and improve surgical outcomes. The study will provide guidance and contribute to the evidence on the integration of prehabilitation into standard care using adaptive models of health care delivery including telehealth.

Trial Registration

Australian and New Zealand Clinical Trials Registry ACTR 12620000409976; https://anzctr.org.au/Trial/Registration/TrialReview.aspx?id=378974&isReview=true

International Registered Report Identifier (IRRID)

RR1-10.2196/41101
Demographic Data Associated With Digital Inequity Reported in Patient-to-Provider Teledermatology Studies in the United States From 2011 to 2021: Scoping Review (Preprint)
Authors: Miller John , Ioffreda Patrick , Nugent Shannon , Jones Elizabeth
Published: November 2022

BACKGROUND

Patient-to-provider teledermatology relies on a patient’s access to technology to ensure a successful visit. However, access to broadband internet and technology varies across populations in the United States—leading to the digital divide. While teledermatology has been recognized as a model to improve access, little is known about how often demographic data associated with digital inequity are captured in studies.

OBJECTIVE

Given the expansion of teledermatology over the past decade, we sought to determine how often demographic data associated with digital inequity are reported in patient-to-provider teledermatology studies.

METHODS

A scoping literature review search was conducted using the search term teledermatology in the following databases: PubMed, Embase, and the Cochrane Database of Systematic Reviews. All studies published between December 31, 2011, and December 31, 2021, that evaluated patient-to-provider teledermatology were eligible.

RESULTS

In total, 1412 publications describing teledermatology were identified, of which 46 met the inclusion criteria. Race or ethnicity was the most frequently reported demographic characteristic (28/46, 61%). However, only 41% (19/46) of studies were representative of race or ethnicity, defined as including >20% nonwhite participants. Studies rarely reported the number of participants greater than 65 years of age (14/46, 30%), preferred language (9/46, 20%), income (6/46, 13%), highest level of education (5/46, 11%), or access to a device (4/46, 9%). Studies conducted after the onset of the COVID-19 pandemic were significantly more likely to report preferred language (9/25, 36% vs 0%; P=.002) and appeared more likely to report other demographic data associated with digital inequity, without reaching statistical significance (P>.05).

CONCLUSIONS

Demographic data associated with digital inequity are rarely reported in patient-to-provider teledermatology studies to date. These studies frequently lack adequate representation of racial and ethnic minorities. With increased calls for equitable representation in dermatology studies, future teledermatology studies can improve the reporting of race and ethnicity and consider demographic data associated with digital inequity as an important criterion in research design.
Cadaveric Studies Utilizing Augmented Reality in Pedicle Screw Placement: A Systematic Review  (Preprint)
Authors: Strigenz Adam , Bak Taylor , Zavurov Gabriel , Morris Matthew , Shahsavarani Shaya , Verma Rohit B.
Published: November 2022

BACKGROUND

Spinal procedures often employ real-time imaging techniques to ensure accurate implant placement. Augmented Reality (AR) is a burgeoning technology with a wide range of applications. In surgery, AR is a novel system that allows for superimposed visual information directly onto the body. The efficacy of AR in pedicle screw placement has been examined in cadaveric studies.

OBJECTIVE

Our objective is to review current literature that assesses the accuracy, utility, and limitations of AR in cadaveric spinal procedures.

METHODS

This systematic review was performed using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The search terms consisted of “augmented reality pedicle screw cadaver”. Studies that utilized AR in pedicle screw placement using a human cadaveric study design were included. The technical accuracy of pedicle screw placement using AR as compared to the current standards was examined.

RESULTS

11 results were returned from the initial search, 7 of these fitting inclusion criteria. An additional landmark article was added for review. Three of the articles were excluded as they failed to meet inclusion criteria. When compared to current image-guided techniques (n=3), AR’s accuracy yielded mixed results. When compared to freehand techniques (n=2) and preplanned trajectories (n=3), there was greater accuracy in the AR screw placements compared to freehand placements while AR screw placements were deemed clinically accurate when deviation from preoperative paths was assessed.

CONCLUSIONS

The technical accuracy of pedicle screw placement using AR is significantly more accurate compared to placement using freehand technique but not significantly different compared to the screws guided with current image-guided modalities. Potential benefits of AR include the reduced need for radiation. Technical limitations exist in registration concerns and imperfect headset ergonomics. More research should further assess clinical accuracy and to address limitations noted.
State-owned Enterprises Investment Management Status and Optimization Strategy
Authors: Liang Ma , Mei Meng
Published: November 2022

In recent years in China’s booming market economy, along with the transformation of the market economy on the reform of the state-owned economic system also came into being, in order to increase the source of profit channels of state-owned enterprises, do a good job of the value-added work of state-owned enterprise assets, many state-owned enterprises choose to diversify development, and this trend is now very obvious. The development of enterprises has also produced a number of problems that have had a significant impact on the quality and returns of investments, causing unnecessary losses and increasing unnecessary risks for many state-owned enterprises. The article will be based on the current situation of investment projects and management of state-owned enterprises, analyze the problems that exist in them, put forward effective improvement measures and targeted countermeasure suggestions for the investment management of state-owned enterprises, and promote the high-quality development of state-owned enterprises.
Volume of natural gas released into the atmosphere in leakage situations - Review and analysis
Authors: Almeida Julio Cézar de , Sardá Alexandre Pescador , Oliveira Hermes Stefano Ferreira de
Published: November 2022

The natural gas leakage rate plays an important factor in simulating leaks in gas transportation and distribution pipelines. The method for leakage rate calculation involves identifying the geometry and type of leak opening, associated with the application of the theories of thermodynamics and gas dynamics, as well as energy conservation equations. In this article, a review and analysis of the flow of gas released into the atmosphere in cases of accidents of this nature is carried out. Such a situation is critical, given that certain leaks can create very extensive danger zones around the immediate vicinity of the leak point.
Impact of Space on Food Sales: An experiment in a Brazilian supermarket
Authors: Lucas Paulo Italo Jordão de , Merlo Edgard Monforte , Rodrigues José de Souza
Published: November 2022

This article evaluate the space-sales elasticity of a basket of food products. The research adopted a before-after experiment with a control group. We change product spaces in a supermarket for these five categories and then analyze what happened with sales. Results show that all types of food varied above the control group. However, only the three categories considered essential and present in consumption habits had statistical confirmation based on the Chi-Square Test.
The focus of research on private supplementary tutoring in China in the past two decades
Authors: Li Yufei , Ventura Alexandre
Published: November 2022

In recent years, private supplementary tutoring has developed rapidly, and its market size has expanded rapidly, which has attracted widespread attention from researchers in the fields of politics, economy, and education at home and abroad. This study uses the knowledge graph system provided by CiteSpace software to sort out 149 related literature on private supplementary tutoring research in China from 2000 to 2021 included in the Web of Science. The study found that "private tutoring theory", "private tutoring and educational equity", "private tutoring institutions", "private tutoring policy", "private tutoring and family capital", and "private tutoring and public education" is a research hotspot in this field in China in the past two decades. Private supplementary tutoring research in China started late, and the research paradigm is different from that of international research, and the research methods used are relatively simple. On the theoretical basis, the theoretical research on private supplementary tutoring is relatively weak and has not yet formed a complete system.
Winston Black, Medicine and Healing in the Premodern West. A History in Documents
Authors: Silva Carmen
Published: November 2022

Winston Black, Medicine and Healing in the Premodern West. A History in Documents
Comparative Analysis of Clinical Outcomes of Open Appendectomy and Laparoscopic Appendectomy
Authors: Srivastava Dr. Shriya
Published: November 2022

Abstract: We know that the Open appendectomy (OA) is standardized among surgeons and, OA is typically completed using a small right lower quadrant incision and postoperative recovery is usually uneventful. It is the second most common general surgical procedure performed in India and the most common intra-abdominal surgical emergency, with a lifetime risk of 6%. Study aimed to compare the clinical outcomes between laparoscopic and open appendectomy. Material and methods: The present study was conducted in the Department of General Surgery of our medical college. For the study, we retrospectively viewed the medical records of patients aged 60 years or more with acute appendicitis who underwent Laparoscopic appendectomy (LA) and were compared to patients who underwent open appendectomy (OA). A total of 70 patients (35 each for LA and OA) were selected. The analysis of preoperative, intra-operative, and postoperative parameters was done and was compared.
GC-MS Analysis of Extracted Essential Oil of Piper betle L.
Authors: Sarkar Dr. Urmila , Sawardekar Sensei Surendra
Published: November 2022

Abstract: The Piper betle L. plant leaves contain aroma. A strong sense of aromatic constituents determines the enrichment of an essential oil components to be present in a plant part. The extracted oil by hydro-distillation method was analyzed through GCMS method. A total 19 volatile components qualitatively and quantitatively by GC-MS. The research experiment of detecting components is observed to be effective to utilize in the food and cosmetic industry in the field of research and development aspects. The presence of compounds shows the phytochemical foundation for the use of extracted oil in the field of applied food industry and cosmetic industry. The research successfully concludes on identifying the components effective for the applications for a wide range of research experiments
Study of Partial Replacement of Cement Using Cow Dung Ash and Marble Dust Combination and Sand Using Glass Powder for M25 Grade of Concrete
Authors: Chouhan Pratik , Sharma Shanu , Maru Vaibhav Raj , Jamra Prince , Shah Imran
Published: November 2022

Abstract: The use of cement in concrete industries increasing day by day. Concrete is the most popularly used construction material in civil engineering industry because of its high structural strength, stability and durable. The most important part of concrete is the cement, fine aggregate, and coarse aggregate. In this modern era, many new technologies of construction materials are introduced. Growth of population, urbanization and industrialization has increased the requirement of cement. The production of cement leads to environmental issues due to release of gaseous pollutants. Cement manufacturing industry is one of the CO2 emitting sources besides deforestation and burning of fossil fuels. The global warming is caused by the ejection of greenhouse gases, such as CO2, to the atmosphere. Among the greenhouse gases, CO2 contributes about 65% of global warming. The global cement industry contributes about 7% of greenhouse gas emission to the earth’s atmosphere. The study for the use of Cow Dung Ash (CDA) and marble dust as partial replacement in production of concrete. The experiments were designed to study the effects of adding Cow Dung Ash (CDA) and marble dust in various percentages by weight 5%, 10%, 15% and 20% for M-25 grade of concrete and cure for the periods of 7, 14, and 28, days respectively before testing for the Compressive strengths.
Chinese people aged over 60 and intergenerational family cohabitation: A moderated mediation model of role perception, resources, gender, family power
Authors: Liu Xin , Bai Shu-Ying
Published: November 2022

We explored whether the perception of older adults of their role in the family mediated the relationship between resource contribution and sense of power, and if this relationship was moderated by gender. For data collection we adopted a stratified sampling method to recruit 1,200 Chinese
people aged over 60 years who were living in intergenerational cohabitation with their adult children in Mengzhou City, China. The results showed that the family role perception of older adults mediated the relationship between their resources (including housing ownership and income level
relative to that of their adult children) and their family decision-making power. Further, gender moderated the influence of resources on role perception, in that the relationships among housing ownership, relative income level, and role perception tended to be stronger for men than for women.
The theoretical and practical implications of these findings are discussed.
Dos Alagados à terra firme: processo de produção de uma favela, ausência do Estado e impactos das dinâmicas socioespaciais na vida dos moradores
Authors: Brito Alison Conceição , Rodrigues Emília Amélia Pinto Costa
Published: November 2022

O bairro dos Alagados caracterizou-se como um conjunto de casas e pontes de madeira, as chamadas palafitas, e os moradores dessa comunidade foram submetidos a um processo de realocação, em que foram retirados das palafitas e direcionados a conjuntos habitacionais em locais de terra firme. Esse processo foi iniciado em 1980 e finalizado somente nos anos 2000, revelando sua complexidade. Diante disso, o presente texto objetiva compreender os impactos que essas mudanças socioespaciais representaram na vida desses moradores. Os principais resultados apontaram que, de fato, houve mudança no que tange à qualidade de vida, à dignidade e a aspectos relacionados à estrutura, demonstrando que as políticas de organização urbana são de suma importância para a qualidade geral da vida dos atores sociais. Em contrapartida, para os moradores entrevistados, as políticas públicas findaram-se na realocação, visto que não houve melhoria em outros aspectos da vida, como acesso a outros direitos, como segurança pública, saúde e lazer.
SHANGHAI COOPERATION ORGANIZATION IN 2022: ECONOMIC AGENDA OF UZBEKISTAN CHAIRMANSHIP AND ORGANIZATION’S DEVELOPMENT PROSPECTS
Authors:   Financial University under the Government of the Russian Federation, Mikhnevich S.V.
Published: November 2022

Economic aspects of the agenda of Uzbekistan Chairmanship in the Shanghai Cooperation Organization (SCO) in 2022 are considered. Key documents submitted for approval at the meeting of the SCO Council of Heads of State are analyzed. Particular attention is paid to the prospective institutional developments of the organization.
Technical-energy-economic multi-objective optimization of ionic liquid-based CO2 /NH3 separation from melamine tail gas
Authors: Duan Yuanmeng , Zhan Guoxiong , Shi Sensen , Zeng Shaojuan , Dong Haifeng , Abildskov Jens , Huusom Jakob , Zhang Xiangping
Published: November 2022

Melamine production is known to produce tail gas with a significant
amount of CO2 and NH3. Ionic liquid as a green and excellent solvent is
to be used for separating melamine tail gas. This paper aims to present
a detailed multi-objective optimization (MOO) for the CO2/NH3 separation
of the tail gas by ionic liquid (IL) in technical-energy-economic
evaluation. Functional IL ([Bim][NTf2]) was selected, the ionic
liquid-based process was designed, and process performances were
investigated by process simulation and optimization. According to the
optimization results, specific cases with different objective functions
were chosen, and the relationship between key parameters was analyzed.
The results showed that the ionic liquid-based technology could realize
a better performance regarding the technical-energy-economic than the
base case. Deeper analyses with the influence of operation parameters
with evaluation index were carried out, thus providing support to the
industrial application of the new separation technology.
Experiment and numerical simulation of friction resistance of CO2 foam-based fracturing fluid in shale gas reservoir
Authors: Kong Xiangwei , Wan Xiong , Guo Zhaoyue , Chen Qing , Li Song
Published: November 2022

Shale gas exploratory development requires a huge water source for
hydraulic fracturing, but the well sites are mainly located in hills,
which limits the industrialization of shale gas development. The CO2
foaming fluid can meet the requirements of fracturing fluid in fracking
and relieve pressure on water resources. The friction calculation of the
CO2 foaming hydro-fracturing fluid in the conduit flow is key to the
reliability of the overall fracture engineering, which affects the
formation stimulation effect. The friction properties of CO₂ foaming
hydro-fracturing fluids were investigated by conducting flow experiments
in HTHP conditions, and the influence of pressure, temperature, foam
mass, and flow rate on the friction properties was obtained.
Mathematical models of frictional drag coefficients have been developed
to predict the frictional force of CO2 foaming gel hydro-fracturing
fluids in turbulent flows, which can be useful in evaluating the rating
of CO2 foaming hydro-fracturing designs.
Genomic and morphological analyses of Asian honeybee subspecies, Apis cerana sanshasis, suggest it's evolutional origin and adaption to island
Authors: Gao Jinglin , Tang Xiangyou , Zhao Shan , Tao Kunlin , Shi Xinyan , Song Huali , Yao Yuxin , Jiang Yan , Wang Tianbin , Li Xiang , Zhao Dongxiang , Xu Jinshan
Published: November 2022

It’s important to discover new resources and expand knowledge of the
distribution range of Apis cerana for the conservation and utilization
of genetic resources. Here, we newly sequenced genomes and apply
population genetic and morphological analysis methods using publicly
available genome-wide datasets to investigate the origin and adaptation
of A.cerana sanshasis from Yongxing Island. The results showed SanshaId
colony was significantly genetically differentiated from others with an
average Fst of 0.2669, indicating a level of subspecies differentiation.
Morphological clustering also showed significant differences, especially
the tongue length of SanshaId colony was significantly smaller than that
of others. In summary, we concluded that A.cerana sanshasis is a
subspecies of A.cerana. Population history analysis showed SanshaId
population has a recent common ancestral feature with Hainan’s, and
subspecies differentiation occurred around 0.57 Ma due to geological
movements causing geographic isolation. We examined the genetic
variation between the recently marginalized colonies from HainanId and
SanshaId, and found high frequency nonsynonymous mutations gene in
SanshaId colony involved in Glutathione metabolism and other signaling
pathways, among which a gene potentially related to tongue length
morphology, Cuticular, was subject to evolutionary selection; meanwhile,
differential tissue expression profiles showed a correlation with
glucose metabolism genes are highly expressed in the midgut, suggesting
these genes may be associated with adaptation to tropical island
environments. Our results expand the understanding of the distribution
range of Asian honeybee and provide the basis for understanding the
population dynamics of A.cerana sanshasis and the molecular evolutionary
mechanisms of adaptation to tropical island environments.
A general framework to quantify and compare ecological impacts under temporal dynamics
Authors: Volery Lara , Wegmann Daniel , Bacher Sven
Published: November 2022

Biodiversity is diminishing at alarming rates due to multiple
anthropogenic drivers. To mitigate these drivers, their impacts must be
quantified accurately and comparably across drivers. To enable that, we
present a generally applicable framework introducing fundamental
principles of ecological impact quantification, including the
quantification of interactions between multiple drivers. The framework
contrasts biodiversity variables in impacted against those in unimpacted
or other reference situations, while accounting for their temporal
dynamics through modelling. Properly accounting for temporal dynamics
reduces biases in impact quantification and comparison. While
considering temporal dynamics requires more data than snapshot
comparisons, our framework remains broadly applicable at only minimal
extra costs. The framework addresses key questions around ecological
impacts in global change science, namely, how to compare impacts under
temporal dynamics across stressors, how to account for stressor
interactions in such comparisons, and how to compare the success of
management actions over time.
Human Resource Management in Health: An analysis of community medical camp as short-term medical intervention to deal with shortage of health workers in rural India.
Authors: Nandu Kannothu Thazha Kuni
Published: November 2022

After longstanding political discussion over developing national public
health systems, achieving universal health coverage, preferably
publically funded programmes becomes the current agenda for societies
around the world. However, this is happening at a time when the world is
facing shortage of millions of health care professionals including
doctors, nurses, midwives, and support workers. The most affected are
developing countries struggling to come up with innovative strategies to
address the challenge. Large parts of the rural population in India rely
on untrained medical professionals, making it the only option for
medical support in many villages. Methods: The study was conducted among
participants and organizers of medical camp conducted at a rural village
in southern part of India. The study employed a cross sectional
descriptive study design to analyze the importance of medical camp as a
short term medical intervention in dealing with shortage of human
resources in rural villages. The needs, expectations and satisfaction of
participants and organizers of the camp regarding health care workers
were analyzed using thematic analysis methods to answer the research
question. Results: The themes that emerged from data analysis shows that
community medical camp approach attempts to complement the shortage of
human resources and other resources essential for smooth functioning of
primary health care services in rural areas. A coordinated effort to
train village health workers and keeping them in a network of health
care professionals from nearby towns who will be frequently available in
the villages will serve the rural people better.
Beta-diversity buffers fragmented landscapes against extinctions
Authors: Dambros Cristian , Izzo Thiago , Vicente Ricardo , Peres Carlos
Published: November 2022

Agricultural expansion has markedly reduced forests and reconfigured
landscapes. These changes incur a well-known detrimental impact on the
biodiversity of local forest patches, but the effects on species
persistence at broader geographic scales are widely debated. We
investigated how regional diversity is affected by habitat loss,
fragmentation, and cattle grazing, and how species respond to
deforestation both locally and regionally. We also investigated how the
heterogeneity in species distribution (beta-diversity) alters species
responses across scales. The vast majority of the 251 ant species found
in our study were negatively affected by both habitat loss and cattle at
local forest patches, drastically reducing diversity at these patches
compared to pristine forests. Despite local declines in diversity,
however, heavily fragmented landscapes could still retain most species
due to the high heterogeneity in species distribution. Beta-diversity is
the main component of regional diversity, and this component is
maximized when remnant primary habitats in a landscape are spread across
vast areas. Although preserving local diversity may be important for the
adequate functioning of the ecosystem, our results indicate that the
maintenance of many small forest patches in a landscape can buffer
regional biodiversity against local species extinctions. Our results
suggest that even small forest remnants in otherwise deforested
landscapes can prevent most regional-scale species extirpations, and
therefore also merit conservation efforts.
Contact Mechanics-based Gait Generation and Trajectory Tracking Algorithm for Radial-skeleton Robots
Authors: Yang Dun , Liu Yunfei , Ding Fei , Hu Kangxin , Yu Yang
Published: November 2022

Radial-skeleton shape-changing robots are rough-terrain robots and
exhibit many advantages in the aspect of mobility, such as excellent
terrain adaptability, light weight, good portability, and stable
configuration. However, existing gait generation methods are rough and
yield low tracking accuracy because the leg-ground contact friction is
difficult to predict and control. In addition, no closed-loop control
scheme has been proposed for this type of robot. In this study, we
designed a 12-legged radial-skeleton robot with a radial expansion ratio
of 2.08. Based on the prototype, we proposed a high-precision gait
generation algorithm that can be used to any multi-legged
radial-skeleton robot and implemented a closed-loop control scheme for
accurate path tracking. Combining the contact friction and multi-body
dynamics model, the robot prototype exhibits the advantages of
omnidirectional motion, high-precision tracking, and motion robustness.
By manufacturing a prototype and conducting comparative experiments, we
verified that the proposed method yields good performance in terms of
trajectory tracking accuracy and robustness in the cases of unknown
terrain and interference.
Caracterização das demandas judiciais de acesso a medicamentos no estado da Bahia
Authors: Damasceno Catanheide Izamara , Assunção Costa Lindemberg , Souza Santana Gisélia
Published: November 2022

Objetivo: Identificar as características das demandas judiciais por medicamentos contra a Secretaria da Saúde do Estado da Bahia (SES-BA) no período de 2002 a 2008. Metodologia: Estudo empírico descritivo transversal, com abordagem metodológica qualitativa e quantitativa, cuja unidade de análise é a ação judicial, movida contra a SES-BA. Resultados: Foram identificadas 361 ações judiciais impetradas contra o Estado da Bahia nos anos de 2002 a 2008, tendo por objeto o fornecimento de medicamentos. Os medicamentos mais solicitados foram infliximabe, trastuzumabe e as insulinas glargina e aspart; dentre as doenças mais frequentemente citadas nos processos encontram-se os cânceres, as doenças endócrinas, nutricionais e metabólicas e do sistema conjuntivo e osteomuscular. Cerca de 30% dos medicamentos solicitados faziam parte do elenco do SUS. Conclusões: Considerando que o medicamento mais demandado já fazia parte do elenco do SUS e que os medicamentos para o tratamento do câncer não são fornecidos pela assistência farmacêutica, faz-se necessário ampliar a divulgação a respeito das normas do SUS e, mais especificamente, da assistência farmacêutica, como os critérios utilizados na seleção dos medicamentos que compõem os elencos, como ter acesso e como utilizar racionalmente os medicamentos para profissionais de saúde e operadores do Direito.
Desempeño productivo y calidad de canal de cerdos mestizos sabaneros en ceba alimentados con una dieta rica en aceite de palma
Authors: Bolívar-Sierra Andrés F. , Suescun-Ospina Sandra T. , Ocampo-Duran Álvaro
Published: November 2022

El cerdo sabanero, raza criolla de Colombia presente en la Orinoquia, es un genotipo local que posee diversas ventajas, entre las que sobresalen el altogrado de adaptación a las condiciones ambientales y su abundancia en varios departamentos de la región. Factores que podrían constituir una estrategiapara incrementar el potencial productivo de la industria porcícola regional. Sin embargo, poco se ha explorado sobre el aporte que esta raza puede hacercruzada con razas comerciales en función de su rusticidad y adaptabilidad. El objetivo de este estudio fue evaluar el desempeño productivo y calidad decanal de cerdos mestizos (sabanero x comercial) en fase de ceba (20 a 90 Kg) en comparación con cerdos comerciales (Landrace x Pietrain). Los cerdosfueron alimentados con una dieta rica en ácidos grasos, utilizando aceite crudo de palma como principal fuente energética. Fueron determinadosparámetros productivos como ganancia de peso y conversión; así como algunas características de la calidad de la canal (rendimiento, diámetro del ojo dellomo y espesor de grasa dorsal). No se encontraron diferencias significativas en los parámetros de desempeño productivo, con ganancias diarias de pesode 522 y 524g respectivamente, consumo de 1,3 kg y conversión de 2,5 para ambos grupos raciales. Tampoco en las características de la canal como espesor de grasa dorsal (23 y 21,47 mm) ni diámetro del ojo del lomo (8 y 10,07 cm), excepto en el rendimiento en canal, que evidenció diferencias significativas (P<0,05) resultado superior para los cerdos comerciales (71,54 y 76,17 %). El cerdo criollo sabanero en cruce con líneas comerciales podría ser una alternativa productiva viable, que permitiría su uso sostenible y conservación. Es necesario realizar futuros ensayos que permitan determinar la calidad de su carne, con posibilidad de generar productos con valor diferenciado que compense su menor rendimiento en canal.
Association of Estimated Glomerular Filtration Rate With Progression of Albuminuria in Individuals With Type 2 Diabetes
Authors: Hanai Ko , Mori Tomomi , Yamamoto Yui , Yoshida Naoshi , Murata Hidekazu , Babazono Tetsuya
Published: November 2022

OBJECTIVE

To elucidate the association of glomerular filtration rate (GFR) at baseline with subsequent progression of albuminuria in individuals with type 2 diabetes.

RESEARCH DESIGN AND METHODS

This was a single-center retrospective cohort study of 6,618 Japanese adults with type 2 diabetes and urinary albumin-to-creatinine ratio of <300 mg/g, comprising 2,459 women and 4,159 men with a mean (± SD) age of 60 ± 12 years. The exposure was baseline estimated GFR (eGFR) (mL/min/1.73 m2), treated as a categorical variable and classified into five categories: ≥90, 75–90, 60–75, 45–60, and <45, as well as a continuous variable. The outcome was progression of albuminuria category (i.e., from normoalbuminuria to micro- or macroalbuminuria or from micro- to macroalbuminuria). Hazard ratios (HRs) for the outcome were estimated using the multivariable Cox proportional hazards model. In the analysis treating baseline eGFR as a continuous variable, the multivariable-adjusted restricted cubic spline model was used.

RESULTS

During the median follow-up period of 6.3 years, 1,190 individuals reached the outcome. When those with a baseline eGFR of 75–90 mL/min/1.73 m2 were considered the reference group, HRs (95% CIs) for the outcome in those with a baseline eGFR of ≥90, 60–75, 45–60, or <45 mL/min/1.73 m2 were 1.38 (1.14–1.66), 1.34 (1.14–1.58), 1.81 (1.50–2.20), or 2.37 (1.84–3.05), respectively. Furthermore, the inverse J-shaped curve was more clearly shown by the spline model.

CONCLUSIONS

This study of Japanese adults with type 2 diabetes suggests that both high and low GFRs are implicated in the pathogenesis of albuminuria progression.
The Impact of Carbamylation and Anemia on HbA1c’s Association with Renal Outcomes in Patients with Diabetes and Chronic Kidney Disease
Authors: Tang Mengyao , Berg Anders , Rhee Eugene P. , Allegretti Andrew S. , Nigwekar Sagar , Karumanchi Ananth , Lash James P. , Kalim Sahir
Published: November 2022

 

  

OBJECTIVE 

HbA1c can predict risk for microvascular complications in patients with diabetes. However, HbA1c’s reliability in chronic kidney disease (CKD) has been questioned, with concerns including competition from another post-translational protein modification, carbamylation, acting on the same amino groups as glycation; and anemia with reduced erythrocyte lifespans leading to altered glycation accumulation. We investigated whether carbamylation and anemia modify the impact of HbA1c on renal outcomes in patients with diabetes and CKD. 

RESEARCH DESIGN AND METHODS

In 1,516 participants from the Chronic Renal Insufficiency Cohort study with diabetes and CKD, Cox regression models were applied to evaluate the association between HbA1c and CKD progression (composite of end-stage kidney disease or 50% decline in estimated glomerular filtration rate [eGFR]), stratified by carbamylated albumin (C-Alb) quartiles and anemia. 

RESULTS

The mean eGFR was 38.1 mL/min/1.73 m2, mean HbA1c was 7.5% (58 mmol/mol), median C-Alb was 8.4 mmol/mol. HbA1c was lower in the higher C-Alb quartiles. During a median follow-up of 6.9 years, 763 participants experienced CKD progression. Overall, higher HbA1c was associated with an increased risk of CKD progression (adjusted hazard ratio 1.07, 95% CI 1.02-1.13). However, using stratified analyses, HbA1c was no longer associated with CKD progression in the highest C-Alb quartile, but did show a monotonic increase in CKD progression risk across each lower C-Alb quartile (P-interaction =0.022). Anemia also modified the association between HbA1c and CKD progression (P-interaction=0.025). 

CONCLUSIONS 

In patients with co-existing diabetes and CKD, the association between HbA1c and CKD progression is modified by carbamylation and anemia. 

  
Laser etching of 2D materials with single-layer precision up to ten layers
Authors: Yao Yikun , Zhao Xinjia , Tang Xiangqian , Li Jianmei , Shan Xinyan , Lu Xinghua
Published: November 2022

Patterned 2D materials with layer-controlled thickness and precise lateral resolution are of great potential for many applications. Laser etching is a promising technique for large-scale patterning of 2D materials, but better control in film thickness is strongly desired. Here, we explore the dynamic characteristics in the laser etching process in which a local temperature lock phenomenon is observed as laser power reaches the etching threshold. A layer-by-layer etching strategy is then developed based on the temporal evolution of the local temperature as measured by in-situ Raman spectroscopy. Employing such a method in a typical layered material MoS2, we demonstrate thickness control up to ten layers in layer-by-layer laser etching. The local temperature lock during laser etching is explained by thermodynamic simulation of temperature distribution within the 2D material under laser illumination. The influence of substrate thermal conductivity on the thickness of the controlled laser etching has been revealed. The results are valuable for potential applications of 2D material devices built with complex layered structures.
Utilization of Gas Sensor Array and Principal Component Analysis to Identify Fish Decomposition Level
Authors: Sumanto Budi , Fakhrurrifqi Muhammad
Published: November 2022

Fish meat is a source of minerals and protein and contains excellent nutrients for the human body. However, non-fresh (rotting) fish are sometimes in the market for sale. Consuming rotting fish puts people at risk of getting diseases. This paper describes research to build a smelling device (e-nose) to identify fish freshness. It aims at detecting unsafe fish flesh to sort them out from being sold. We cut red snapper into cubes and put them into an open space at room temperature for five days. During the period, a gas sensor array acquired data of gas smell from the rotting fish. The output voltage of the sensors was processed using the differential baseline method. Later, feature extraction took the maximum value from the response of the gas sensor array, while the Principle Component Analysis (PCA) method identified the pattern. The results suggest that the gas sensor array responds to changes in the smell of fish meat that undergo a decay process. The PCA method is capable of recognizing the pattern of the maximum value characteristic of the gas sensor array response, as evidenced by the cumulative values of PC1 and PC2 reaching 95.95% with an accuracy rate of 98.2%. It shows the correlation between the aroma profiles of fish meat during the spoilage process, which produces a sharper aroma due to microbiological growth in the fish meat.
Hubungan Cyberloafing Dengan Prokrastinasi Kerja Pada Pegawai Dinas Kependudukan Dan Pencatatan Sipil
Authors: Filasufiah Nadia Edelwais
Published: November 2022

Pegawai dituntut untuk menggunakan waktu seacara efektif sehingga dapat meningkatkan produktifitas. Pegawai bukannya kekurangan waktu melainkan melakukan aktifitas yang tidak berhubungan dengan pekerjaan yang menyebabkan perilaku menunda-nunda yang disebut prokrastinasi kerja. Salah satu yang menyebabkan prokrastinasi kerja ialah cyberloafing yakni menggunakan internet yang difasilitasi oleh instansi untuk keperluan pribadi. Penelitian ini bertujuan untuk mengetahui hubungan cyberloafing dengan prokrastinasi kerja. Metode penelitian ini adalah kuantitatif korelasional dengan alat ukur skala cyberloafing dan skala prokrastinasi kerja. Jumlah subjek sebanyak 78 orang pegawai Dinas Kependudukan dan Pencatatan Sipil. Hasil penelitian menunjukkan terdapat hubungan yang positif antar cyberloafing dengan prokrastinasi kerja Dinas Kependudukan dan Pencatatan Sipil (DISDUKCAPIL) Kota.
Pola Asuh Otoritatif dan Psychological Well-Being Pada Remaja
Authors: Lestari Yuliana Intan
Published: November 2022

Psychological well-being merupakan suatu kondisi dimana remaja mampu mencapai fungsi psikologis yang optimal sebagai hasil pengalaman hidup yang diperolehnya. Salah satu faktor yang mempengaruhi psychological well-being adalah evaluasi terhadap pengalaman hidup seperti pola asuh yang diberikan orangtua, salah satunya yaitu pola asuh otoritatif. Tujuan utama dalam penelitian ini adalah untuk mengetahui bagaimana hubungan antara pengasuhan otoritatif dengan psychological well-being pada remaja. Penelitian ini melibatkan 154 remaja di Pekanbaru yang dipilih menggunakan teknik cluster random sampling. Data penelitian diperoleh dengan menggunakan skala psikologi yakni  Psychological Well-Being Scale oleh Ryff (1996) dengan koefisien reliabilitas sebesar 0,924 dan skala pola asuh otoritatif berdasarkan teori Baumrind (1991) dengan koefisien reliabilitas sebesar 0,931. Berdasarkan hasil analisis data menunjukkan bahwa pola asuh otoritatif dan psychological well-being pada remaja berada pada kategori tinggi. Hasil analisis korelasi product moment diperoleh koefisien korelasi (r) sebesar 0,656 serta sumbangan efektif pola asuh otoritatif terhadap psychological well-being sebesar 0,43 atau 43% yang berarti terdapat hubungan positif antara pola asuh otoritatif dengan psychological well-being pada remaja. Artinya semakin baik pola pengasuhan otoritatif yang diterapkan orangtua maka semakin baik pula psychological well-being pada diri remaja.
Konseling Religius Dalam Mengatasi Kesehatan Mental Pasca Pandemi Covid 19
Authors: Zatrahadi M. Fahli , Nirwana Herman , Mudjiran Mudjiran , Karneli Yeni
Published: November 2022

Religious counseling in dealing with mental health after the COVID-19 pandemic. I conducted this research using the library method used in this study using a qualitative approach (library research). Literature-based as study material is the object of research. The analytical technique used in answering the research problem is using content analysis techniques and strengthened by using the results of the Nvivo software coding. The results show that the spread of the COVID-19 virus impacts people’s mental health disorders. So that in reality it requires counseling help to reduce anxieties because of the news that the number of deaths has increased because of corona. Here, religious counseling can be carried out by bathing repentance, repentance prayers, remembrance, and other worship. Likewise, in dealing with the post-covid-19 pandemic so that past events do not happen again and always remember Allah SWT.
Pengaruh Pembiayaan Bank Syariah dan Kredit Bank Konvensional Terhadap Pertumbuhan Ekonomi di Indonesia
Authors: Angrayni Serly , Aimon Hasdi , Putri Dewi Zaini
Published: November 2022

This research purpose are to the analyse the how the impact of dependent variables, there are Sharia Financing, Commercial Credit, Inflation, Government Expenditure, and Human Development  in terms of the Economic Growth in Indonesia. Methods that being used are Panel Least Square and used Fixed Effect Model, the estimation results show that Sharia Financing has a positive effect but not significant on Economic Growth in Indonesia, Credit Commercial has a significant positive effect on Economic Growth in Indonesia, Inflation has a significant negative effect on Economic Growth in Indonesia, Government Expenditure has a significant positive effect on Economic Growth in Indonesia, and Human Development has a significant positive effect on Economic Growth in Indonesia.
Analisis Estimasi Produksi Kelapa di Kabupaten Padang Pariaman
Authors: S M Afdal , Aimon Hasdi , Satrianto Alpon
Published: November 2022

This research purpose are to estimate and explained the impact of number of coconut plants and labor to production of coconut in Padang Pariaman regency. The type of this research is descriptive research, the data used are primary and secondary data and analyzed using Multiple Linear Regression. The estimation results show that the number of coconut plants has a positive and significant effect on the amount of coconut production in Padang Pariaman Regency and the labor has a not significant positive effect on the amount of coconut production in Padang Pariaman Regency.
Analisis Kausalitas Belanja Pertahanan dan Pertumbuhan Ekonomi di Indonesia
Authors: Putra Bayu Rahmadi , Yeniwati Yeniwati , Adry Melti Roza
Published: November 2022

This study aims to determine and analyze the causality between defense spending and economic growth in Indonesia. Data analysis used is descriptive analysis and inductive analysis. In the inductive analysis using the VAR approach, there are several tests, namely: (1) Test Stationaryity; (2) Cointegration Test; (3) Optimal Lag Determination; (4) Granger Causality Test; (5) Impulse Response Function; (6) Variance Decomposition. Research results show that: There is no causal relationship between defense spending and economic growth in Indonesia. However, there is a direct relationship of defense spending to economic growth.
Faktor – Faktor Yang Mempengaruhi Pemerataan Pendapatan di Indonesia
Authors: Sidqiy Achmad , Amar Syamsul
Published: November 2022

This research illustrates the influence of economic growth, domestic investment and  government expenditure to distribution income in Indonesia with variables (1) GDP per capita, (2) Domestic Investment and (3) Goverment  Expenditure. This research uses panel data from 2012-2017, which consist 32 province in Indonesia, by using a method linear regression and use Fixed Effect Model (FEM). the results obtained from this research is (1) Economic growth has a negative significant effect to inequality income in Indonesia. (2) Domestic investment has negative effect but not significant to inequality income in Indonesia. (3) Goverment expenditure has a positive and significant effect to inequality income in Indonesia
Analisis Interrelationship Infrastruktur, Foreign Direct Investment (FDI) dan Kesempatan Kerja di Indonesia
Authors: Efendi Rahmad Zul , Azhar Zul
Published: November 2022

This study aim to analyze the interrelationship between infrastructure, Foreign Direct Investment and employment in Indonesia, The data used in this study  are secondary data from 2013 to 2018 in 32 provinces in Indonesia using panel data on the VAR method. The result show that there is no interrelationship between infrastructure and FDI in Indonesia, there is a interrelationship between employment opportunities and infrastructure in Indonesia and there is no interrelationship between FDI and employment opportunities in Indonesia