bluuebunny/crossref_metadata_2025 huggingface dataset:
Analiza wskaźnikowa jako narzędzie stosowane do oceny kondycji finansowej spółki
Authors: Lesiak Magdalena
Published: July 2022

W opracowaniu przedstawiono możliwość wykorzystania analizy wskaźnikowej do oceny kondycji finansowej spółki notowanej na GPW. Celem przeprowadzonych badań jest omówienie praktycznego zastosowania wspomnianej analizy, której dokonano na podstawie przeglądu literatury przedmiotu, a także pełnej sprawozdawczości (bilansu oraz rachunku zysków i strat). Rezultatem badań jest ocena standingu finansowego na przykładzie spółki akcyjnej działającej w sektorze żywności, produkującej wyroby cukiernicze, przede wszystkim na polski rynek, w porównaniu ze średnimi wynikami osiąganymi w branży. Okres badawczy obejmuje 10 lat. Otrzymane wyniki wskazują, że opisywana spółka prowadziła konserwatywną strategię dotyczącą aktywów i pasywów. Jednak w przeciwieństwie do konkurentów odznaczała się agresywną polityką nakierowaną na zwiększenie odbiorców produktów lub usług. Ponadto badana spółka stosowała surową politykę kredytowania odbiorców i miała niski poziom ogólnego zadłużenia. Z tych względów można wnioskować, że spółka koncentrowała swoje działania przede wszystkim na zapewnieniu bezpieczeństwa finansowego. Jednocześnie przyjęta strategia umożliwiła jej osiągnięcie lepszych wyników w obszarze rentowności niż pozostałe spółki działające w tym samym sektorze.
Pengaruh Penambahan Ekstrak Aloe vera Terhadap Karakteristik Fisik Basis Polietilen Glikol Sediaan Suppositoria
Authors: Ardana Mirhansyah , Arundina Wilujeng Cahya , Gamma Sabaniah Indjar
Published: July 2022

Ekstrak Aloe vera berpotensi untuk dikembangkan menjadi sediaan suppositoria karena terbukti memiliki aktivitas laksatif. Pada penelitian ini sejumlah ekstrak yang dosisnya telah dikonfersi dicampurkan dengan basis suppositoria polietilen glikol (PEG). Kemudian dilakukan evaluasi karakteristik fisik meliputi kekerasan, disolusi, dan titik leleh terhadap basis dan sediaan suppositoria yang mengandung ekstrak. Hal ini bertujuan untuk melihat pengaruh penambahan ekstrak terhadap karakteristik basis PEG suppositoria yang telah dioptimasi komposisinya, sehingga akan mempermudah formulator untuk melakukan penyesuaian komposisi basis terhadap persyaratan sediaan suppositoria yang baik. Hasil pengujian menunjukan bahwa ekstrak tidak mengubah kekerasan basis suppositoria, tetapi mempengaruhi disolusi dan titik leleh basis. Ekstrak Aloe vera mempercepat disolusi basis dari 37,163 menit menjadi 36,933 menit dan meningkatkan titik leleh basis dari 62,967 °C menjadi 80,467 °C. Dari data yang diperoleh dapat disimpulkan bahwa basis PEG yang ditambahkan ekstrak Aloe vera tidak memerlukan penyesuaikan komposisi karena perubahan yang terjadi masih sesuai dengan persyaratan dan tidak mempengaruhi performa sediaan dalam hal pelepasan zat aktif.
In Silico Study of Pulutan (Urena lobata) Leaf Extract as Anti Inflammation and their ADME Prediction
Authors: Wahyuningsih Doti , Purnomo Yudi , Tilaqza Andri
Published: July 2022

Inflammation is the basic for the pathogenesis of several diseases both of degenerative and non-degenerative disease. Urena lobata is a medicinal plant that can be found in Indonesia and has been used traditionally to cure influenza, inflammation and fever. However, there have been few reports about their anti-inflammatory activity and their mechanism action are still unclear. The aim of study to evaluate the anti-inflammatory activities of active substances from U.lobata leaf and their pharmacokinetic property through in silico study. lobata leaf was extracted by digeration methods using ethanol solvent. Therefore, the active substances in the extract was analyzed by Liquid Chromatography-Mass Spectra (LC-MS). Pharmacokinetic property and physicochemical of active compounds were evaluated using pkCSM online tool. Anti-inflammatory activity of U. lobata active compound on phospholipase-A2 (PLA-2), cyclooxygenase-2 (COX-2) and lipoxygenase-5 (LOX-5) were evaluated by in silico study. Ethanolic extract of U. lobata contained five active compound, there are stigmasterol, ?-sitosterol mangiferin, gossypetin and chrysoeriol. Molecular docking study indicated stigmasterol and ?-sitosterol of U. lobata have a strong activity as anti-inflammatory based on the estimation of inhibition constant (Ki) value against PLA2 and COX-2. Meanwhile, mangiferin and gossypetin have a stronger anti-inflammatory effect on LOX-5 among others compound. U. lobata has anti-inflammatory activity through inhibition on COX-2 greater than on PLA2 and LOX-5.
O perfil social e a geração de renda em assentamentos rurais sob influência do Cinturão da soja e milho na Amazônia Matogrossense
Authors: Molinari Atila de La Corte , Nogueira Roberta Martins , Beber Roberto Carlos , Corassa Janaina de Nadai , Pires Evaldo Martins
Published: July 2022

Os aspectos socioeconômicos, legais e produtivos das propriedades rurais vinculadas aos programas de reforma agrária são pontos de grande relevância para a fixação das famílias e para a efetividade desta política pública, sobretudo na Amazônia. Assim, neste trabalho teve-se por objetivo avaliar a influência dos fatores sociais e produtivos sobre a geração de renda em assentamentos rurais da Amazônia mato-grossense. O estudo se baseou em uma pesquisa social aplicada, com a coleta de dados econômicos, sociais e produtivos de 48 propriedades rurais, através de um questionário estruturado, acrescido de observações de campo. As propriedades foram amostradas por tipicidade, considerando o uso da terra nas seguintes modalidades: extrativismo, lavoura e arrendamento da área a terceiros.  Os resultados demonstraram que há diferença no perfil social em função da atividade agrícola principal da propriedade e que a renda obtida em cada uma das atividades também sofre influência das atividades produtivas estudadas. Pode-se concluir que o tipo de atividade agrícola desenvolvida na propriedade leva o assentado rural a depender de rendas extras, fato este que deve impulsionar discussões sobre as políticas públicas que apoiem os beneficiários do programa de reforma agrária após o recebimento da terra.
Paradoxos no impedimento para licenciamento da agricultura tradicional em assentamento ambientalmente diferenciado em Anapu, Pará
Authors: De Oliveira Parise Francisco José , Porro Roberto
Published: July 2022

Este artigo contribui com debates sobre impactos causados por assentados em florestas da Amazônia, a partir de estudo de caso analisando procedimentos para licenciamento ambiental em Projeto de Desenvolvimento Sustentável (PDS). Os desafios de assentados para licenciar roçados no PDS Virola Jatobá, em Anapu, Pará, foram analisados desde as motivações para protocolar um projeto de adequação ambiental, até o indeferimento do pedido pelo órgão competente, após 19 meses. A resposta negativa fragilizou tanto assentados que defendiam a manutenção de práticas legais, como a proposta de assentamento ambientalmente diferenciado. No contexto de ilegalidade vivenciado na Amazônia, políticas de comando e controle são essenciais para conter o desmatamento e crimes ambientais. Contudo, a atuação inconsistente do Estado em relação a assentados em PDS reforça a colisão entre direitos sociais e ambientais, impedindo tanto o alcance de metas de justiça social quanto as de conservação ambiental. Reduzir desmatamentos desse segmento depende de políticas adequadas e da criação de alternativas econômicas que lhes ofereçam oportunidades de renda, sem, porém, lhes tolher as relações sociais estabelecidas no cultivo da roça.
DSS for Mobile-Based Determination of the Quality of Gayo 1 Coffee Seedlings by Combining the AHP-WP Method
Authors: Nurjannah Mia , Samsudin Samsudin , Irawan Muhammad Dedi
Published: July 2022

Determining the quality of Gayo 1 coffee seeds with manual calculations can affect time efficiency because manual calculations often result in inconsistent and time-consuming calculations. A decision support system is needed to determine the quality of Gayo 1 coffee seeds with consistent and accurate calculations and processed through computational speed. Applying the AHP-WP method can determine the quality of coffee seeds of the Gayo 1 variety at IP2TP Gayo. The discussion that becomes the focus is the application of the AHP method to determine the weight of the coffee seed criteria. The resulting weight can be continued in the calculation of the WP method to determine the quality of the Gayo 1 coffee seed based on the alternative preference value or vector S. The results of the study provide information regarding the quality of coffee seeds that have been tested for quality.
Thermohydraulic Performance Intensification of Wavy, Double-Layered Microchannel Heat Sink with Height Tapering
Authors: Borah Santanu , Ranjan Tamuli Bhaskar , Bhanja Dipankar
Published: July 2022

Thermohydraulic performance analysis of a wavy, tapered, double-layered microchannel heat sink is done numerically. The coolant used is water with temperature-dependent properties in single-phase flow considering Reynolds number in the range of 100–500. Uniform heat flux at the base of the microchannel heat sink is applied. The study suggested that the tapered, wavy channel has given better thermal performance than the straight, wavy channel; however, pressure drop has increased. Also, a comparison with a smooth, tapered, double-layered microchannel heat sink showed 13.6% enhancement on overall performance with wave [Formula: see text], [Formula: see text], Reynolds [Formula: see text], and tapering [Formula: see text] when all three plates of the double-layered microchannel heat sink are considered wavy. Moreover, it has also been observed that considering only the middle plate wavy, the cost of fabrication could be minimized and still similar enhancement over a smooth, double-layered microchannel heat sink could be obtained.
Perfil epidemiológico das meningites no estado do Pará, de 2010 a 2020
Authors: Nunes André Luis Silva , Costa Kallyto Amorin , Santos Gustavo Pintos dos , Barbosa Aritana Ferreira Santos
Published: July 2022

Objetivo: Traçar o perfil epidemiológico das meningites no estado do Pará de 2010 a 2020. Métodos: Trata-se de um estudo epidemiológico, retrospectivo, longitudinal, de caráter exploratório e analítico, além de ser quantitativa, com coleta de dados do Departamento de Informática do Sistema Único de Saúde (DATASUS) entre os anos de 2015-2020. Resultados: No estado do Pará, de 2010 a 2020 foram confirmados 4426 casos de meningite. O maior número absoluto de casos por ano foi em 2018 com 515 (11,63%). O sexo masculino foi o mais acometido com 2483 registros (57,41%). A raça parda lidera com 3393 casos (76,66%). De acordo com a faixa etária, a maior prevalência ocorreu entre 20 e 39 anos com 1470 (33,21%). Em relação a distribuição dos casos no estado do Pará por regiões de saúde, a região Metropolitana I foi a que apresentou maior incidência dos casos com 3579 registros, correspondendo a 82,38% do total. Conclusão: Infere-se que a meningite bacteriana no Pará apresentou um aumento no número dos casos notificados entre os anos de 2010-2020. O perfil epidemiológico desses pacientes mostrou maior acometimento do sexo masculino, raça parda e maior incidência na região metropolitana I.
Bibliometric analysis of the top 100 most-cited articles in neurofibromatosis
Authors: Alnefaie Nada , Almutairi Othman T. , Alturki Abdulrahman Y. , Bafaquh Mohammed
Published: July 2022

Background:

Neurofibromatosis (NF) is an umbrella term that refers to three distinct disease entities: NF Type 1, Type 2, and schwannomatosis. Here, we reviewed the scientific performance and the most influential publications on NF.

Methods:

A keyword-based search was performed using the Scopus database. The top 100 articles were grouped based on NF types and the studied entities. The differences between the articles, authors, and journals were quantified based on certain parameters. Other parameters were collected for the complete citational analysis.

Results:

The top 100 articles were published between 1961 and 2020. The most trending period of research was in the 1990s and articles studying the clinical aspect and the underlying genetic correlation made up 84% of all articles from the list. The United States of America (USA) had the highest number of contributions (69 articles, 69%). The top institute of contribution to the list was the Howard Hughes Medical Institute, USA (14 articles, 14%). Author-based analysis reveals that the neurologist D. H. Gutmann from St. Louis Children’s Hospital, USA, was the most active and authored 11 articles (11%) on the list.

Conclusion:

The publication trends show that articles studying medical and surgical management were of little interest. The top 100 articles did not include any randomized control trials, and the highest level of evidence was obtained from reviews of pooled knowledge as well as population-based and longitudinal studies.
Leukocyte adhesion defect: Clinical correlation with integrin expression and genetics
Authors: Iyengar Vaishnavi V. , Taur Prasad , Gowri Vijaya , Chougule Akshaya , Kambli Priyanka , Madkaikar Manisha , Desai Mukesh M.
Published: July 2022

Objectives:

Leucocyte adhesion defect 1 (LAD1) is an autosomal recessive defect in integrin expression. In this study we present a case series of 19 children with LAD1. We analysed their clinical and laboratory data and correlated it with integrin expression and underlying genetic defect.

Material and Methods:

Retrospective case record study of all children diagnosed with LAD1 between 2012 and 2021.

Results:

Ten females and 9 males were included. Eight cases were born of consanguineous marriage. 78% (15/19) had disease onset within one year of life and 8 of them were neonates. Neonates with LAD1 commonly presented with omphalitis, late-onset sepsis and respiratory infections (RTI). Most common organism isolated from blood was pseudomonas (4/8). CD11/CD18-expression ranged from severely reduced (6/8) to moderately reduced (2/8) but disease was uniformly fatal in the 7/8 patients who could not undergo hematopoietic stem cell transplant (HSCT). Seven children presented between 1month and 1year of age with RTI, bacterial sepsis and soft tissue abscess. Four expired, 1 survived after HSCT and 2 were alive at last follow up. CD11/CD18-expression ranged between 0-1.6% except in 2 cases. One child with 11%-expression is alive without transplant. Another child had 0%-CD11 but 17%-CD18-expression with very low MFI (mean florescence intensity). She succumbed at 20 months of age with perianal abscess, sepsis and RTI but prior to this fatal episode she developed autoimmune cutaneous lesions with lymphocytic infiltration. Four children presented beyond infancy. Median age at onset of symptom was 2 years with skin abscess, oral ulcers, severe periodontitis with tooth loss and pyogenic arthritis. Three of them survived without HSCT, 1 was alive at last follow up. CD11/CD18-expression ranged from 20-32% in these children. Details of cord separation was available in 17 cases and it was delayed (beyond 2 weeks of life) in 9 children. Of the 17 cases with genetic analysis of ITGB2 gene, 16 had a homozygous and 1 had compound heterozygous variant. (nonsense: 2; splice site variants:5; 8: missense variants; 2: deletion).

Conclusion:

Disease onset less than 1 year age was fatal, irrespective of CD11/CD18 expression. Integrin expression levels beyond 20% and splice site mutation were associated with 100% survival without HSCT but were not event free. Pseudomonas sepsis is the commonest infection in LAD1 neonates. Between 1month to 1year, RTI and gram-negative sepsis dominated and beyond 1st-year skin/perianal abscess was common. Delayed separation of cord was present only in 52% of cases.
Spinal neurofibromas presenting as quadriparesis in a case of neurofibromatosis Type 2
Authors: Kulkarni Shilpa , Joshi Manasee
Published: July 2022

Neurofibromatosis Type II (NF2) is a neurocutaneous syndrome with autosomal dominant inheritance caused by mutation in NF2 gene that codes for protein merlin. It is associated with various tumours such as vestibular schwannoma, meningiomas, ependymomas, etc. in central and peripheral nervous system. The Manchester criteria is used for its diagnosis. We report a case of a 9 year old girl with café au lait spots and plexiform neurofibromas who presented with gradual onset UMN type of progressive quadriparesis over 20 days. Magnetic resonance imaging brain and spine revealed bilateral vestibular schwannomas and multiple spinal neurofibromas which were confirmed on histopathologic examination, thereby confirming diagnosis of NF Type 2.
Economy of the Arctic coastal territories: analysis of the state and development trends
Authors:   State University of Land Use Planning, Novikov A.V.
Published: July 2022

The article deals with the issues of economic development of the coastal territories of the Russian Arctic (blue economy). The author assesses the state and development of certain sectors of the blue economy, including marine (coastal) biological resources, mineral resources and hydrocarbons, renewable energy, seaports and infrastructure, coastal tourism. He shows the influence of the economy of coastal territories on socio-economic development, the creation of new jobs, the investment attraction, the traditional crafts of the indigenous peoples of the North and the improvement of the population living standards. The author identifies the development trends of the Arctic coastal territories, which consist in the complex nature of industrial development of the territory taking into account the requirements of environmental protection, the development of renewable energy sources (solar, wind energy), modernization of port infrastructure, creation of a network of specially protected natural Arctic territories.
Terrestrial vertebrates of Cozumel Island, Quintana Roo: Amphibians
Authors: Alamillo-Paredes Alejandro , González-Romero Alberto , Jiménez-Orocio Oscar
Published: July 2022

Cozumel es la isla mexicana con mayor riqueza de especies de anfibios y reptiles. En la isla se han registrado un total de nueve especies de anfibios (únicamente anuros), ninguna bajo alguna categoría de riesgo o considerada como endémica, de las cuales Eleutherodactylus planirostris es una especie introducida nativa de las Indias occidentales del mar Caribe (Cuba, Bahamas y las Islas Caimán). También se reconocen 34 especies de reptiles, siendo una de ellas la lagartija endémica de la isla de Cozumel, Aspidoscelis cozumela: especie cuya peculiaridad reside en ser partenogenética (forma de reproducción en donde el desarrollo del embrión es a partir de la célula huevo no fecundada), por lo cual todos los individuos son hembras. Cotidianamente los frágiles ecosistemas insulares se ven amenazados por actividades antropogénicas que llevan a la introducción de especies no nativas. Tal es el caso de la especie de Boa constrictor introducida en el año de 1971, la cual, a pesar de ser nativa de México, se ha considerado invasora en la isla y para el 2011 se reportaba que era la especie de vertebrado terrestre más abundante y mejor distribuido en la isla, lo cual representa una amenaza verdadera como depredador de la fauna nativa en un ecosistema insular sumamente vulnerable. Respecto a las especies marinas, a la isla llegan a anidar tres especies de tortugas marinas: la tortuga de carey (Eretmochelys imbricata), la tortuga caguama (Caretta caretta) y la tortuga verde (Chelonia mydas). Las cuales se encuentran protegidas bajo la nom-059-semarnat-2010 y iucn y catalogadas bajo algún nivel de protección por la iucn. La franja costera de la zona oriental del Área de Protección de Flora y Fauna la porción norte y la franja costera oriental, terrestres y marinas de la Isla de Cozumel son sitios de anidación de Caretta caretta y de Chelonia mydas, las cuales registran las mayores densidades de desove donde se han registrado hasta tres mil nidos en promedio por año para estas dos especies. Al ser un ecosistema costero donde de igual manera se encuentran zonas de manglar y humedales que se utilizan como zonas de alimentación, reproducción y desarrollo, es posible la presencia de reptiles semiacuáticos como es el caso del cocodrilo americano (Crocodylus acutus), que está bien representado en estas zonas. En el pasado fueron introducidas diferentes especies domésticas como el perro (Canis falmiliaris), el gato (Felis catus), el ratón doméstico (Mus musculus), la rata negra (Rattus rattus) y la serpiente (Boa constrictor). Los gatos, la rata negra y la boa actualmente cuentan con poblaciones silvestres bien establecidas que compiten y depredan a las especies nativas.
Prospects for the application of unified tax payment in the digital economy
Authors: Gulkova E. L. , Karp M. V. , Tipalina M. V.
Published: July 2022

The unified tax payment is to simplify the payment of taxes, reduce the time for filling out payment documents and reduce the number of mistakes in them. The purpose of the paper is to analyze the use of the unified tax payment from the perspective of its impact on tax administration and taxpayers’ activities.

In this article, the authors set the following tasks: to determine the procedure for paying the unified tax payment; to assess the possibility of expanding the practice of its application and identify possible problems.The data on the voluntary remittances of the unified tax payment by physical persons during the period from 2019 to 2022 is presented. A critical analysis of the draft laws No. 46702-8 «On Amendments to Part One and Part Two of the Tax Code of the Russian Federation (in terms of improving the procedure for paying taxes) and No. 20281-8 «On conducting an experiment to establish a special tax regime «Automated simplified taxation system» is carried out. The paper highlights the main problems which companies may face if the institution of the «unified tax payment» is applied on a mandatory basis and identifies the possible ways to solve them. The authors’ recommendations and conclusions can be used in the development of conceptual provisions of tax policy.
Using of turquoise organization’s concept to benchmark indicators of creative team management
Authors: Akopyan A. R. , Vorontsova Yu. V.
Published: July 2022

The purpose of this study is to study the possibilities of applying the turquoise type organization model in creative industries, where there is a need for constant staff development to achieve maximum results. When analyzing the turquoise organization model, a number of factors should be taken into account, on which it relies, and also choose from a number of them those that really have a significant impact on the formation of the turquoise approach in creative industries. At a certain stage, from a non-standard creative management model, one way or another, it is necessary to return to traditional management methods while maintaining the basic principles of the turquoise organization, which can be considered as a standard. The introduction of such tools into the creative team/process management system qualitatively improves the mechanism of managerial decision-making, and also allows it to be debugged through unidirectional actions of both managers and the entire creative team. To implement the task of standardization, a universal model of quantitative assessment of qualitative indicators was developed, taking into account the dynamics of their changes. At the same time, a model was built for selecting indicators for the formation of a set of personnel characteristics in order to benchmark them relative to the level of the same characteristics of the turquoise organization, taking into account the possibility of their transversal change over time.
Democracy and principles of socio-economic development
Authors: Sychev A. A. , Zaytseva E. V. , Tolkachev P. S.
Published: July 2022

The article examines the existing political and economic trends: democratic and authoritarian forms of government. An attempt is made to describe the essential content of the values of democracy, as well as their implementation in the economic sphere. All this justifies the role of e-technologies only as a quantitative factor in the development of democracy. It is shown that the form of government is primarily based on personal value choice, which leads to effective or ineffective socio-political equilibrium states. It is shown that the construction of supporting democratic institutions does not implement the principles of power: service and hierarchy. Therefore, the transition to a new qualitative state is possible through education, awareness of the principles of power, their free acceptance, but cannot be carried out artificially, through a system of institutions introduced from the outside.
Assessment of social industrial management
Authors: Sharokhina S. V.
Published: July 2022

The article defines the criteria for the effectiveness of social management of an industrial enterprise. Some methodological approaches used in evaluating the effectiveness of social management are considered. The authors propose a methodology for determining the effectiveness of social management of an enterprise, which is based on the use of certain conditional calculated indicators and can be applied in the conditions of digitalization of the economy, and also involves implementation in several stages. The effectiveness of social management, according to the authors, must be assessed based on the results of the implementation of the social development plan developed for each enterprise. The authors recommend taking this approach to assessing the effectiveness of social management as one of the examples of the search for specific ways to create objective prerequisites and a methodological basis for studying a systematic approach to organizing work.
Signal-Processing and Adaptive Prototissue Formation in Metabolic DNA Protocells
Authors: Samanta Avik , Hörner Maximilian , Liu Wei , Weber Wilfried , Walther Andreas
Published: July 2022

The fundamental life-defining processes in living cells, such as replication, division, adaptation, and tissue formation, take place via intertwined metabolic reaction networks orchestrating downstream signal processing in a confined, crowded environment with high precision. Hence, it is crucial to understand and reenact some of these functions in wholly synthetic cell-like entities (protocells) to envision designing soft-materials with life-like traits. Herein, we report on a programmable all-DNA protocell (PC) composed of a liquid DNA interior and a hydrogel-like shell, harboring DNAzyme active sites in the interior whose catalytic bond-cleaving activity leads to a downstream phenotype change in the protocells, as well as triggers prototissue formation. In this regard, we coupled several tools of DNA nanoscience, such as RNA cleavage, dynamic strand displacement reactions, and multivalent palindromic interactions, in a synchronize pathway so that the input signal can be processed inside the protocells and generate downstream cues giving rise to metabolic adaptive behavior. For example, the compartmentalized DNAzyme catalyzes the bond-cleavage of a substrate that releases a DNA strand in situ to trigger a strand displacement reaction at the shell of the protocells leading to a change in color resembling a “phenotype-like” change in cells, and finally to establish communication with other protocells via multivalent interactions.
Novel dual-motor nanorotator assembled by cyclo[18]carbon and figure-eight carbon hoop
Authors: Liu Zeyu , Wang Xia , Lu Tian , Wang Jiaojiao , Zhao Mengdi , Yan Xiufen
Published: July 2022

Two unique nanorings recently generated, namely cyclo[18]carbon (C18) and oligoparaphenylene (OPP), were theoretically designed to assemble an extraordinary dual-motor supramolecular rotator (2C18@OPP) with large included angle. The size adaptability and shape complementarity of guest C18 to host OPP as well as the thermodynamic analysis of 2C18@OPP showed that the complex can form easily and exist stably below 404 K. Energy decomposition and various real-space function analyses of host-guest interaction revealed the characteristic and nature of the non-covalent interaction in this supramolecule. The scanning results of the potential energy surface (PES) showed that the rotational barrier of C18 in OPP is extremely small, implying the possibility of the supramolecular complex as an ultrafast molecular rotator. Molecular dynamics (MD) simulations confirmed that C18 and OPP can spontaneously assemble into up to 1:2 ring-in-ring host-guest complexes, and C18 can rotate at an ultrahigh speed in OPP at ambient temperature. The thermodynamic parameters of the nanorotator at different temperatures were also investigated to determine the thermal stability of 2C18@OPP. Such assemble is the first example of two C18 molecules being encapsulated simultaneously to realize a dual-motor nanorotator and promises to open new avenues for the construction of complicated molecular machines as well as the controllable storage of C18.
Catalysis at the Origin of Life
Authors: de Graaf Ruvan , Sojo Victor , Hudson Reuben
Published: July 2022

The construction of hypothetical environments to produce organic molecules such as metabolic intermediates or amino acids is the subject of ongoing research into the emergence of life. Experiments specifically focused on an anabolic approach typically rely on a mineral catalyst to facilitate the supply of organics that may have produced prebiotic building blocks for life. Alternatively to a true catalytic system, a mineral could be sacrificially oxidized in the production of organics, necessitating the emergent ‘life’ to turn to virgin materials for each iteration of metabolic processes. The aim of this perspective is to view the current ‘metabolism-first’ literature through the lens of materials chemistry to evaluate the need for higher catalytic activity and materials analyses. While many elegant studies have detailed the production of chemical building blocks under geologically plausible and biologically relevant conditions, none appear to do so with sub-stoichiometric amounts of metals or minerals. Moving toward sub-stoichiometric metals with rigorous materials analyses could finally demonstrate the viability of an elusive cornerstone of the ‘metabolism-first’ hypotheses: catalysis. We emphasize that future work should aim to demonstrate decreased catalyst loading, increased productivity, and/or rigorous materials analyses for evidence of true catalysis.
chromMAGMA: regulatory element-centric interrogation of risk variants
Authors: Nameki Robbin , Shetty Anamay , Dareng Eileen , Tyrer Jonathan , Lin Xianzhi ,   The Ovarian Cancer Association Consortium, Pharoah Paul , Corona Rosario I , Kar Siddhartha , Lawrenson Kate
Published: July 2022

Candidate causal risk variants from genome-wide association studies reside almost exclusively in noncoding regions of the genome and innovative approaches are necessary to understand their biological function. Multi-marker analysis of genomic annotation (MAGMA) is a widely used program that nominates candidate risk genes by mapping single-nucleotide polymorphism summary statistics from genome-wide association studies to gene bodies. We augmented MAGMA to create chromatin-MAGMA (chromMAGMA), a method to nominate candidate risk genes based on the presence of risk variants within noncoding regulatory elements (REs). We applied chromMAGMA to a genetic susceptibility dataset for epithelial ovarian cancer (EOC), a rare gynecologic malignancy characterized by high mortality. This identified 155 unique candidate EOC risk genes across five EOC histotypes; 83% (105/127) of high-grade serous ovarian cancer risk genes had not previously been implicated in this EOC histotype. Risk genes nominated by chromMAGMA converged on mRNA splicing and transcriptional dysregulation pathways. chromMAGMA is a pipeline that nominates candidate risk genes through a gene regulation-focused approach and helps interpret the biological mechanism of noncoding risk variants for complex diseases.
A New Method for Calculating the Heat Flux of Rivers in the Absence of Gauging-Station Data
Authors:   Lomonosov Moscow State University, Magritsky D. V.
Published: July 2022

In the paper, a comparative analysis of previously developed methods for calculating the heat flux of rivers in the absence of gauging-station data are given, and a new method for such calculations is proposed. It is based on the Maps of specific annual heat flux of zonal rivers and empirical dependencies of heat flux on the average height of the catchment area. An example of such a map is the “Map of specific annual heat flux (MT, 109× kJ/km2) of rivers in the northeast of the Asian part of Russia” plotted on the data for the period from 1950/1955 to 2018 and on the basis of data from 112 gauging stations. General recommendations for calculating the annual heat flux of medium-sized rivers that do not have posts, the intra-annual distribution of heat flux, the values of heat flux at the mouths of large rivers are set out in the paper. The values of heat flux calculated for the marine mouths of region large rivers and the sections of seacoasts between these mouths are given as an example of the implementation of the new recommendations. The list of new materials that help calculations includes new maps of average monthly water temperatures (May-October), the dependence of water temperature and heat flux on the average height of the catchment area, the division of the territory of the Northeast Asian part of Russia into 10 altitude-thermal zones, the relationship between heat flux and water runoff, the catchment area of the river and other materials. In total, data from 34 weather stations, 231 posts with water temperatures and 145 posts with water discharges were used in the research.
Problematic issues of accounting and reporting in extractive industries in the context of sustainable development
Authors: Zatoka T.V. , Chyzhevska L.V.
Published: July 2022

Search, extraction and enrichment of minerals are of the strategic importance for sustainable economic development. Accounting as an information system should provide interested users with reliable, complete and unbiased information on mining, however, national and international accounting standards governing the accounting of mining enterprises and reporting requirements contain only general principles of regulation. The article analyzes the financial statements and audit reports of mining companies to reflect their information about activities. It was found that companies are not interested in disclosing information related to exploration and evaluation of minerals, the impact of such exploration on the environment, the cost of environmental protection. The inclusion of environmental sustainability indicators in the reporting of extractive industries will help to consume resources efficiently, minimize disturbances, reduce pollution, as well as close and rehabilitate depleted mine lands. Attention should be paid not only to the information in the reporting, but also to the relevant audit.
Exploring How Men Who Are Victimised by Female Partners Experience Disclosure and Help-Seeking From Services in Aotearoa New Zealand
Authors:   , Langton Burnell Jonothan
Published: July 2022

This research investigated how men who were victimised by a female intimate partner experienced disclosure and help-seeking from both informal sources and formal help-seeking services in Aotearoa New Zealand (NZ). The current study was a part of a broader research project investigating men and women’s experiences of victimisation and perpetration of intimate partner aggression (IPA) in NZ. Eleven semi-structured interviews were analysed using Braun and Clarke’s (2006) reflexive thematic analysis. Three overarching themes relating to men’s experiences of disclosure and help-seeking from services in NZ were found. The first theme described the broader sociocultural ideas of hegemonic masculinity and sexism relating to beliefs the men held, that they felt others and services had, and the impact of these beliefs. The first theme consisted of two subthemes: 1) normative beliefs, and 2) the impact of normative beliefs. The second theme identified the importance of social support for male victims of IPA. The second theme consisted of four sub-themes: 1) who men speak to, 2) why men speak up, 3) the positive and negative outcomes of social support, and 4) why social supports are necessary. The third theme detailed what characteristics and approach to gendered beliefs of IPA allowed services to either assist men well in their help-seeking or give men a negative help-seeking experience. The third theme consisted of three sub-themes: 1) the gendered treatment of victims within services, 2) that services that understand men serve them well, and 3) the visibility of services. These findings add to the growing body of literature that has investigated men’s experiences of help-seeking to detail what supports men need and gives them better outcomes. The need for policies, services, and broader education around the nature of IPA are discussed. Future research should look beyond primarily New Zealand European populations, particularly to Māori populations in NZ, to understand the role of marginalisation and inequity has on help-seeking, as well as other cultural factors.
Ritual Ngarosulkeun dan Kekerabatan Pada Masyarakat Tani Pasigaran
Authors: Rizky Luffita
Published: July 2022

Beragam ritual pertanian di wilayah pedesaan Indonesia sampai saat ini dapat ditemui, seperti ritual ngarosulkeun yang dilakukan sehari sebelum panen tiba sebagai bentuk rasa syukur atas panen yang akan didapat esok hari. Penelitian ini dilakukan dengan tujuan mengetahui ritual sebagai penguat kekerabatan pada masyarakat tani. Metode penelitian yang digunakan, adalah etnografi yang bersifat kualitatif. Hasil penelitian menunjukkan, kekerabatan pada masyarakat tani Pasigaran terbentuk bukan hanya berdasarkan biologis. Kerabat dapat terbentuk karena ada kesemaan wilayah tempat tinggal (dulur salembur) seperti tetangga, dan kerabat yang dibentuk karena adanya penggabungan budaya tertentu (dukungan materi dan emosional) yang berlangsung lama seperti dengan pemilik lahan. Tahapan ritual ngarosulkeun merepresentasikan perekat kekerabatan, yaitu adanya pegangan hidup rarangken kersa nyai dan elmu karahayuan. Terdapat nilai kehidupan, di antanya bagi kehidupan, bagi agam dan kepercayaan, dan bagi kelancaran dalam bertani. Asepek penguat kerabat dapat dilihat pada sikap berbagi dan memberi, gotong royong, dan bersilaturahmi.Kata Kunci: Ritual Ngarosulkeun, Kekerabatan, Petani, Kehidupan
Menjilid Sitaralak: Konsep Garap Penciptaan Tari dari Memori Silek Pak Guru
Authors: Sukri Ali , Prihatini Nanik Sri , Supriyanto Eko , Pamardi Silvister
Published: July 2022

Aktifitas silat, selain sebagai praktik untuk meningkatkan ketahanan fisik, juga menjadi bekal ketika menghadapi betapa kerasnya dunia terutama ketika berada di rantau. Hal ini bisa dilihat pada masyarakat Minangkabau zaman dahulu yang menganggap bahwa silat ibarat sebuah pakaian atau identitas diri yang wajib dibawa ke manapun pergi. Penciptaan karya ini mengarah pada pendekatan istilah tradisional Minangkabau, yaitu Kiek Kieh. Istilah Kiek Kieh terdiri atas dua kata yaitu kiek dan kieh. Kiek adalah ‘cara’ atau ‘metode’, atau bisa juga disebut ‘kiat’, sedangkan Kieh bisa diartikan ‘kias’ atau ‘umpama’. Pengertian bahasa kias (figure of speech) adalah pilihan kata tertentu sesuai dengan maksud penulis atau pembicara dalam rangka memperoleh aspek keindahan. Karya menjilid sitaralak ini lahir dalam rangka melihat perkembangan pembelajaran silat di Minangkabau yang pada saat ini sudah mulai ditinggalkan oleh generasi muda. Untuk itu, perlu ada karya seni yang memperlihatkan bahwa silat masih menjadi wilayah yang perlu dikembangkan dan dilestarikan.Kata kunci: Silek, tari, kiek-kieh, menjilid sitaralak
“Kampung Yang Hilang”: Cara Mencari Daya dan Daya Mencari Cara
Authors: Alfiyanto Alfiyanto , Widiastutieningrum Sri Rochana , Sarwanto Sarwanto , Supriyanto Eko
Published: July 2022

Karya tari “Kampung yang Hilang” diciptakan dengan pola garap tari kontemporer dengan pendekatan ekokultural dan partisipatori, untuk mengambil objek tentang anak-anak masyarakat Kampung Ciganitri, baik dikaji secara formal maupun material. Persoalan ini ditafsir kembali sehingga menjadi sebuah pengalaman empirik ekspresi kekinian. Pemilihan pola garap tari kontemporer dengan pemilihan sampling penari anak-anak sebagai media edukasi, di samping juga sebagai wadah bagaimana menuangkan emosi menjadi ekspresi untuk menyampaikan isu-isu kekinian. Mewujudkan proses penciptaan karya tari “Kampung yang Hilang” dilakukan sebuah penelitian artistik, practice based research, serta metode pelatihan Literasi Tubuh Wajiwa untuk menggiring anak-anak Kampung Ciganitri ke ranah kreativitas tari kontemporer. Metode penciptaan mengaplikasikan metode Literasi Tubuh Wajiwa dan garap tari kontemporer membentuk sebuah jejaringan yang saling memperkuat, terjadinya konektivitas dalam mewujudkan nilai edukasi baik nilai intrinsik maupun nilai ekstrinsik untuk meningkatkan kecakapan potensi tubuh anak-anak. Hasil penciptaan ini diharapkan menjadi sebuah proses kreatif penciptaan karya tari “Kampung yang Hilang” menjadi sebuah platform metode penciptaan tari kontemporer sebagai media baru dalam inovasi edukasi dan proses kreativitas penciptaan tari yang berbasis ekologi baik anak-anak maupun lingkungan alam sekitar.Kata kunci: kreativitas, literasi tubuh, kontemporer anak, ekologi
TOMUBA Sajian Karya Seni Toleat dan Musik Bambu
Authors: Christiana Whayan , Gumilar Teguh
Published: July 2022

Judul penciptaan karya seni adalah Tomuba yaitu singkatan dari Toleat dan Musik Bambu. Karya ini merupakaan bentuk karya seni musik bambu dengan mengusung instrumen toleat sebagai media utamanya. Kekuatan timbre dari alat musik Toleat akan dijadikan sebagai sumber ide penciptaan. Karya ini menyajikan nuansa yang menceritakan tentang perubahan fungsi toleat pada masyarakat Subang dari yang awalnya sebagai kalangenan menjadi pintonan. Struktur karya terdiri dari 2 bagian, meliputi bagian A dan bagian B. Metode penciptaan karya seni ini meliputi proses observasi, eksplorasi dan eksperimentasi. Karya TOMUBA ini diharapkan dapat memberikan temuan dan solusi dalam bentuk karya seni sebagai sarana untuk bisa memperkenalkan instrumen khas Subang yaitu toleat dan menjadikan sarana promosi untuk prodi Angklung dan Musik Bambu. Sebagai tawaran bentuk karya seni musik bambu untuk dijadikan sebagai model penciptaan karya seni musik bambu. Kesimpulan karya ini adalah menyajikan kemasan karya baru yaitu ansambel toleat dengan instrumen musik bambu lainnya.Kata kunci: Tomuba, musik bambu, toleat, penciptaan, kalangenan, pintonan
A Fundamental Solution for an Advection Di usion Equation in a Non Uniform Three Dimensional Flow. (c2021)
Authors:   ,   Lebanese American University, Al Hajj Ali Soha
Published: July 2022

We propose in this thesis an analytical solution for the three dimensional Eulerian advection diffusion equation of a scalar tracer transported by a turbulent flow where the mean flow is assumed to be linear in space relative to the center of the patch and where the effects of the small scale eddies are resolved by introducing an effective eddy diffusivity. We show how our solution is obtained by transforming it into a system of equations for the trajectories and for the concentration in the Lagrangian frame. An apparent diffusion coefficient that combines the effects of the advection and the turbulent diffusion is inferred from the solution and some asymptotic behaviors of the diffusion are explored.
SOCIAL-ECONOMIC IMPLICATIONS OF TRANS-BORDER CRIMES IN NIGERIA: 2015-2019
Authors:   Department of Political Science and Public Administration Babcock University, Ilisan-Remo, Babajide Jacob , Opakunbi Oyedamade ,   Department of Political Science and Public Administration Babcock University, Ilisan-Remo
Published: July 2022

The continuous surge in threats to global security especially orchestrated by trans-border - crimes such as money laundering, arms trafficking, drug trafficking and human trafficking, has given rise to a series of new discussions and strategic thinking among scholars and security experts. Nigeria is not an exception to these threats as it has, lately, been witnessing a handful of these palpable security challenges threatening its peaceful corporate existence and economic prosperity. This paper thus examined the dimensions of trans-border crimes and its socio-economic implications for Nigeria. The paper employed qualitative methodology, secondary data collection and descriptive method of analysis. The paper argues that global interconnectedness facilitates increase in trans-border crimes, especially in Nigeria where the unofficial/unmanned borders surpass the official/manned borders. Therefore, it is found that drug trafficking, arms trafficking, trafficking of persons, car smuggling and internet fraud are prevalent trans-border crimes in Nigeria. The socio-economic implications of trans-border crimes are mostly felt in fueling corruption, infiltrating businesses, hindering development and endangering lives and national security. Identifiable causes of increased trans-border crimes in Nigeria include porous borders, political corruption, and compromised security system. It is concluded that trans-border crimes pose serious national challenges that require multi track strategies and coordinated responses from the government, its agencies, transnational agencies, neighbouring governments and the citizens, to address. The paper, thus, recommended that to significantly minimize the menace of trans-border crimes in Nigeria, the government should adequately police the borders while the appropriate law enforcement officers must be well mobilized and equipped to so do.
DETERMINANTS OF WORK-FAMILY CONFLICT: EMPIRICAL EVIDENCE FROM BARAU DIKKO TEACHING HOSPITAL KADUNA
Authors:   Department of Community Medicine, Kaduna State University, Dabo Habiba Zubairu , Kwanbo Mansur Lubabah ,   Department of Accounting, Kaduna State University, Sarki Pamela ,   Department of Ophthalmology, Kaduna State University, Dabo Zainab ,   Department of Business Administration, Kaduna State University
Published: July 2022

There is no equal amount of time or level of psychological involvement devoted to work and family that yields equal satisfaction of work and family roles, hence the objective of this study is to establish whether individual work performance influence work-family conflict. The research design for the study is survey design and Primary Data were used for this study obtained from structured questionnaires with predetermined responses. The study used key informant purposive sampling to administer 300 questionnaires to Doctors, Nurses, Technicians and Lab Attendants at the Barau Dikko Teaching Hospital, Kaduna, The Polynomial regression used for data analysis. Findings revealed that contextual and adaptive performance including counterproductive behavior influence work-family conflict. The study recommends that the organisation should not only focus on employee’s actions or behavior that yields it wellbeing they should also be sensitive to the implication of such action on the family life of the employee, hence more flexible time, family call and onsite family visitation should be seen to accommodate 30% of total work life annually