bluuebunny/crossref_metadata_2025 huggingface dataset:
Per illo oro de Cluniaco . Un témoignage ignoré sur le cens de Ferdinand I er en faveur de Cluny
Authors: Gallon Florian
Published: August 2024

À partir d’une mention passée inaperçue, bien qu’elle figure dans un document édité depuis quarante ans, l’article revient sur un sujet déjà passablement étudié : le cens d’or versé au profit de Cluny par Ferdinand I er de Castille-León. Le texte est une charte donnée le 8 octobre 1062 pour enregistrer l’achat, par le monastère navarrais de San Salvador de Leire, d’une grotte située à proximité de Nájera. Les vendeurs, domna Toda et ses enfants, se séparent de ce bien pour s’acquitter d’une dépense dont ils sont redevables « pour l’or de Cluny » ( per illo oro de Cluniaco ). Après avoir établi la pleine authenticité de ce document, conservé seulement dans un cartulaire du xii e  siècle, on montre qu’il constitue le plus ancien témoignage – et le seul contemporain – du cens de Ferdinand I er . Le texte en renouvelle la connaissance sous trois aspects : sa chronologie, les modalités de sa collecte et celles de son versement.
La création sans mère d’Adam et la conception sans père du Christ. Sources et signification de l’ Ovide moralisé , xiv , v. 5660–5774 et 5995–6120
Authors: Kretschmer Marek Thue
Published: August 2024

Par-ci par-là, le poète anonyme de l’ Ovide moralisé parsème son immense poème, traduisant et commentant les Métamorphoses , de passages souvent tirés d’autres ouvrages ovidiens, étrangers donc à l’hypotexte. Cet article présente une analyse d’un de ces passages qui, à première vue, pourraient être considérés comme de curieuses contaminations textuelles, des morceaux insérés pour le pur plaisir de la compilation, et qui en apparence ne remplissent aucune fonction au-delà de celle d’enjoliver le texte. Le premier volet de l’analyse identifie d’abord les sources du passage en question ( Ovide moralisé , xiv , v. 5660–5774). Il se trouve que le poète français s’est servi des Fastes pour reconstituer à sa manière le mythe de Romulus. Le second volet démontre des résultats encore plus intéressants : chaque étape du mythe a été juxtaposée à un épisode de l’histoire du Salut ( Ovide moralisé , xiv , v. 5995–6120). En développant systématiquement cette allégorisation, notre poète fait preuve d’une grande créativité.
La poétique de Villon ou l’art de la (feinte) correctio ?
Authors: Le Briz-Orgeur Stéphanie
Published: August 2024

L’article revient sur l’œuvre de Villon (hors ballades en jargon) pour tenter de dépasser le constat récurrent de son ambiguïté et de son amoralisme. Afin d’interroger à nouveaux frais les poèmes de « François des Loges » ou « de Montcorbier » « dit Villon », on propose de suivre à toutes les échelles (de la phrase à l’œuvre, en passant par les deux poèmes longs, les ballades ou les rondeaux « recueillis » ou non) les procédures de correction dont use si volontiers l’auteur. La poésie de François Villon apparaît in fine moins contradictoire que totalisante. De fait, grâce à la correctio valant souvent moins annulation que confirmation, les discours fortement intertextuels du poète ne se diluent pas dans la ressemblance avec ce qui les nourrit ; ils sortent renforcés de ce dialogue et appellent à un nouvel ordre, plus juste, ou du moins ajusté aux ennemis ou aux frères humains du poète.
Mathematical modeling of a Hybrid Mutated Tunicate Swarm Algorithm for Feature Selection and Global Optimization
Authors: Althaqafi Turki
Published: August 2024

The latest advances in engineering, science, and technology have contributed to an enormous generation of datasets. This vast dataset contains irrelevant, redundant, and noisy features that adversely impact classification performance in data mining and machine learning (ML) techniques. Feature selection (FS) is a preprocessing stage to minimize the data dimensionality by choosing the most prominent feature while improving the classification performance. Since the size data produced are often extensive in dimension, this enhances the complexity of search space, where the maximal number of potential solutions is 2nd for n feature datasets. As n becomes large, it becomes computationally impossible to compute the feature. Therefore, there is a need for effective FS techniques for large-scale problems of classification. Many metaheuristic approaches were utilized for FS to resolve the challenges of heuristic-based approaches. Recently, the swarm algorithm has been suggested and demonstrated to perform effectively for FS tasks. Therefore, I developed a Hybrid Mutated Tunicate Swarm Algorithm for FS and Global Optimization (HMTSA-FSGO) technique. The proposed HMTSA-FSGO model mainly aims to eradicate unwanted features and choose the relevant ones that highly impact the classifier results. In the HMTSA-FSGO model, the HMTSA is derived by integrating the standard TSA with two concepts: A dynamic s-best mutation operator for an optimal trade-off between exploration and exploitation and a directional mutation rule for enhanced search space exploration. The HMTSA-FSGO model also includes a bidirectional long short-term memory (BiLSTM) classifier to examine the impact of the FS process. The rat swarm optimizer (RSO) model can choose the hyperparameters to boost the BiLSTM network performance. The simulation analysis of the HMTSA-FSGO technique is tested using a series of experiments. The investigational validation of the HMTSA-FSGO technique showed a superior outcome of 93.01%, 97.39%, 61.59%, 99.15%, and 67.81% over diverse datasets.
Integrable dynamics and geometric conservation laws of hyperelastic strips
Authors: Tükel Gözde Özkan
Published: August 2024

We consider the energy-minimizing configuration of the Sadowsky-type functional for narrow rectifying strips. We show that the functional is proportional to the $ p $-Willmore functional using classical analysis techniques and the geometry of developable surfaces. We introduce hyperelastic strips (or p-elastic strips) as rectifying strips whose base curves are the critical points of the Sadowsky-type functional and find the Euler-Lagrange equations for hyperelastic strips using a variational approach. We show a naturally expected relationship between the planar stationary points of the Sadowsky-type functional and the hyperelastic curves. We derive two conservation vector fields, the internal force and torque, using Euclidean motions and obtain the first and second conservation laws for hyperelastic strips.
A Carne em Disputa
Authors: Casadei Eliza Bachega
Published: August 2024

Posto que as escolhas alimentares envolvem classificações e símbolos que revestem seu consumo de um caráter ético e moral, o objetivo do presente artigo é analisar as convocações midiáticas ao consumo das carnes vegetais. A partir dos pressupostos teórico-metodológicos da Análise de Discurso de Linha Francesa, objetivamos estudar diferentes processos de produção discursiva materializados na comunicação de atores midiáticos que convocam ao consumo desse produto como as ONGs vinculadas aos direitos dos animais e marcas produtoras de carne vegetal. Iremos observar os discursos em disputa e as diferentes estratégias discursivas mobilizadas por tais atores nos cenários midiáticos que promovem o consumo de carne vegetal.
Perimenopause
Authors: Yingngam Bancha
Published: August 2024

Perimenopause occurs prior to menopause and manifests as physiological and psychic changes. However, there is a substantial deficit of data and societal information concerning perimenopause. This leads to inadequate perimenopause processing and poor quality of life. Thus, the purpose of this chapter is to offer an overview of perimenopause. It defines the term, which distinguishes it from menopause and explains hormonal inclinations and physiological body occurrences. The chapter covers several symptoms of the perimenopause state, from variations in menstruation to psychological changes, and their implications for women's general quality of life. From this perspective, the provision highlights the role of lifestyle remedies and community assistance in the management of this process. Moreover, this finding suggests the importance of researching individualized remedies and the potential long-term consequences of perimenopause.
Optimizing Perimenopausal Care
Authors: Mishra Prachi
Published: August 2024

This chapter delves into the complex subject matter of perimenopause, harnessing the power of explainable artificial intelligence (AI) to improve precision, accountability, and transparency in diagnosing and comprehending this critical stage in women's lives. In order to address the varied nature of perimenopausal symptoms and their major impact on quality of life, diagnostic techniques that are not only modern but also simple and trustworthy are required. This chapter meticulously dissects the potential of explainable AI in this context, ensuring ethical responsibility, clarity, and reliability in handling sensitive health data through a robust non-empirical research methodology involving extensive literature review, case analyses, and theoretical exploration. It intends to give a complete analysis, strengthening the knowledge base, application, and ethical issues around these AI models, and ultimately contributing to the growth of individualized and effective healthcare solutions.
Education Research and Industry 6.0
Authors: Goel Pawan Kumar
Published: August 2024

The book chapter explores the relationship between Industry 6.0 and education, focusing on its impact on pedagogy, curriculum, and learning. It highlights the need for education to adapt to the demands of Industry 6.0, requiring adjustments in curricula and methodologies. The chapter emphasizes the importance of educational research in identifying effective pedagogical strategies, curriculum design, and the integration of emerging technologies into learning environments. It also explores current trends in educational research, highlighting interdisciplinary approaches and the integration of technology into education. The chapter also discusses the development of future-ready skills and the gap between existing curricula and the skills required for success in the evolving job market. The chapter highlights successful collaborations between educational institutions and industry players, emphasizing the role of real-world experiences in preparing students for Industry 6.0.
Sustainability-Linked Bonds
Authors: Chauhan Rachna , Kour Manjit
Published: August 2024

A country's economic development completely relies upon the support done by the makers of the financial system. Financial makers have consistently made an honest effort to coordinate great and innovative cycles in the framework to accomplish the countries' goal. Another has been, for every one of the nations, to advance success while safeguarding the planet, considered with sustainable development goals, which are integrated in each financial activity to perceive that ending poverty must go hand-in-hand with strategies that build economic growth and address a range of social needs. Sustainability-linked bonds (SLBs) have arisen as significant instruments in the sustainable finance market. They address corporate level targets. They also make their commitments explicit and measurable to bond investors, as well as to environmental regulators. The current chapter upholds the necessity of presenting sustainability-linked bonds in the era of green and sustainability bonds.
Voice-Controlled Drones for Smart City Applications
Authors: Daniel Lawrence I. , Rehash Rushmi Pavitra A. , Prasanna V.
Published: August 2024

Drone production and utilization have skyrocketed in recent years. They are extremely versatile and have many different applications. Due to the ease and possible uses they provide, voice-controlled drone research has attracted a lot of interest recently. This technology makes it possible for users to command drones verbally, doing away with the need for physical controls and allowing for a more intuitive and natural interface. Voice-controlled drones have emerged as a promising technology with various applications ranging from recreational activities to industrial operations. This research chapter provides a comprehensive review of voice-controlled drone systems, highlighting their advancements, challenges, and future directions. The chapter explores the underlying technologies and components involved in voice control, examines the benefits and limitations of voice interaction with drones, and discusses potential applications and areas of improvement. Additionally, it explores the ethical and legal considerations associated with voice-controlled drones.
The Role of AI in Sustainable Business Practices and Reporting in Emerging Economies
Authors: Nnam Imaobong Judith , Okobo Marian Mukosolu , Olaniyan Joshua Damilare
Published: August 2024

This study investigates artificial intelligence and how it can be leveraged upon in order to re-engineer existing business models, towards achieving sustainable development goals. The study analysed factors necessary to ensure an artificial intelligence assisted sustainable business model innovation to provide a framework for businesses in emerging economies. A systematic literature review of existing literature is undertaken using the Scopus database. Filtering processes are employed to arrive at 94 journal articles. The study adopts the PRISMA protocol to allow a comprehensive disclosure of the review process. The review process resulted in the development of thematic areas which provided a framework that guided the study. Case studies were also undertaken, analysed in a qualitative manner in order to capture the perceptions and experiences as well as the problems associated with leveraging artificial intelligence in sustainable business model innovation. The research output includes recommendation and policy implication.
Industry 5.0 at the Core of Society 5.0
Authors: Tyagi Amit Kumar , Kumari Shabnam , Tiwari Shrikant , Subbiah Priyanga
Published: August 2024

Due to Industry 4.0 and its crucial supporting technologies for information and communication, the development and service industries are seeing a radical shift. Big data, the internet of things (IoT), cloud computing, and fog computing are revolutionising the eHealth ecosystem and driving it towards Healthcare 4.0. The health industry, in particular, is experiencing a rebirth of eHealth. As a set of technological procedures bridging the gap between the digital, biological, and physical realms, Healthcare 4.0 has just evolved. Health process efficiency and reliability are the goals of these procedures, which also establish norms for the data-to-information-usage and -access transition. But there's a constantly evolving problem that needs fixing before we can operationalize and qualitatively describe Industry 4.0's contributions to the healthcare industry. This chapter examines the health sector in depth in light of Industry 4.0 and all of its characteristics.
Finance Case Studies
Authors: Binkhamis Mohammed
Published: August 2024

The purpose of this chapter is to present a comprehensive devoted to utilizing case studies in finance education, with a specific focus on the basic principles of finance. The chapter aims to explore how case studies can effectively teach and reinforce key topics, including financial statements, examining financial performance through financial analysis, understanding capital budgeting techniques, computing the cost of capital, and analyzing risk and return. Through these case studies, students can engage with realistic financial scenarios, analyze data, evaluate alternatives, and make sound recommendations.
The Impact of Reconciliation Quality in Strategic Alliances on Financial Innovation
Authors: El Hammoumi Ahmed , El Hammoumi Mohammed
Published: August 2024

Operators of financial institutions in developing economies have a significant impact on economic activity by financing innovative initiatives. This chapter presents an empirical study aimed at discovering the results of the quality of the relationship of financial institutions regarding innovation within strategic alliances. Using a qualitative research model, this study explores the process of positive influence of relationship quality on financial innovation within Moroccan financial institutions engaged in strategic alliances. Four research hypotheses were tested using regression analysis on a sample of 34 strategic alliances formed by Moroccan financial institutions during the 2018-2022 reference periods. The empirical results highlight that the quality of the reconciliation relationships between Moroccan financial institutions has largely contributed to their financial innovation. It is particularly important to combine two essential characteristics: mutual trust and partner commitment.
Gpx4 Regulates Invariant NKT Cell Homeostasis and Function by Preventing Lipid Peroxidation and Ferroptosis
Authors: Sok Sophia P M , Pipkin Kaitlyn , Popescu Narcis I , Reidy Megan , Li Bin , Van Remmen Holly , Kinter Mike , Sun Xiao-Hong , Fan Zhichao , Zhao Meng
Published: August 2024

Invariant NKT (iNKT) cells are a group of innate-like T cells that plays important roles in immune homeostasis and activation. We found that iNKT cells, compared with CD4+ T cells, have significantly higher levels of lipid peroxidation in both mice and humans. Proteomic analysis also demonstrated that iNKT cells express higher levels of phospholipid hydroperoxidase glutathione peroxidase 4 (Gpx4), a major antioxidant enzyme that reduces lipid peroxidation and prevents ferroptosis. T cell–specific deletion of Gpx4 reduces iNKT cell population, most prominently the IFN-γ–producing NKT1 subset. RNA-sequencing analysis revealed that IFN-γ signaling, cell cycle regulation, and mitochondrial function are perturbed by Gpx4 deletion in iNKT cells. Consistently, we detected impaired cytokine production, elevated cell proliferation and cell death, and accumulation of lipid peroxides and mitochondrial reactive oxygen species in Gpx4 knockout iNKT cells. Ferroptosis inhibitors, iron chelators, vitamin E, and vitamin K2 can prevent ferroptosis induced by Gpx4 deficiency in iNKT cells and ameliorate the impaired function of iNKT cells due to Gpx4 inhibition. Last, vitamin E rescues iNKT cell population in Gpx4 knockout mice. Altogether, our findings reveal the critical role of Gpx4 in regulating iNKT cell homeostasis and function, through controlling lipid peroxidation and ferroptosis.
Aeroacoustic Analysis of a Lift-Offset Coaxial Rotor Using High-Fidelity CFD-CSD Loose Coupling Simulation
Authors:   University of California, Jia Zhongqi ,   The Pennsylvania State University, Sharma Kalki , Lee Seongkyu , Brentner Kenneth
Published: August 2024

This paper presents the investigation of acoustics of a lift-offset coaxial rotor in high-speed steady forward flight using high-fidelity Computational Fluid Dynamics (CFD) and Computational Structural Dynamics (CSD) loose coupling tools - Helios and RCAS. Acoustics of the lift-offset coaxial rotor is simulated using the acoustic prediction tool PSU-WOPWOP at eight chosen microphones positioned below the rotor plane. Three forward flight speeds at 100, 150, and 200 knots are selected to investigate the effect of lift-offset, flight speed, and separation distance on acoustics of the coaxial rotor. The total power of the three speed cases is validated against flight test data and shows good agreement. Strong blade-crossover interactions and self-BVI signatures of the coaxial rotor, which are sources of loading noise, have been captured in details via high-fidelity CFD simulations across all speed cases. It has been demonstrated that the magnitude of sound pressure level increases significantly with increasing flight speed and lift-offset. The strength of blade-vortex interaction sound pressure level (BVISPL) appears to decrease dramatically with increasing separation distance at 100 knots. However, higher speed cases do not show a significant reduction in BVISPL with increasing separation distance. Overall, this research study presents noteworthy and novel findings on acoustics of a lift-offset coaxial rotor.
Auralization of Rotorcraft Periodic Flyover Noise from Design Predictions
Authors:   NASA Langley Research Center, Krishnamurthy Siddhartha ,   International Corp., Aumann Aric , Rizzi Stephen , Douglas D.
Published: August 2024

This paper combines the synthesis and propagation of rotorcraft sounds, or auralizations, with their noise predictions and design optimization to incorporate human response into the process of creating low-noise rotorcraft. The NASA Auralization Framework is described and used to auralize the sounds of an AS350 helicopter main rotor at a ground observer from predicted acoustic pressure time histories. This paper uses spherical phase interpolation as part of the sound synthesis. This interpolation is an improvement over the linear phase interpolation described in previous work, which can introduce artifacts in the auralized sound. The effects of noise prediction source resolution are discussed. Two AS350 helicopter main rotor planform optimizations using certification noise metrics as the objective function are performed. One objective function is the Effective Perceived Noise Level metric and the other is the A-weighted Sound Exposure Level metric. The planform optimization includes determining trim state, predicting and propagating source noise, and changing design variables to affect the noise metric. Auralizations of the rotor sounds are computed, and due to their time domain nature, enable a more thorough exploration of sound quality metrics applied to the rotor sounds than traditional 1/3-octave predictions. These other metrics can be used to assess community annoyance and help develop human perception metrics that can potentially be incorporated into the helicopter design cycle.
Improvement of Experiment/Computation BVI Noise Comparisons by Use of a Geometrical Method Applied to Data Assimilation
Authors:   ONERA, Delrieux Yves , Bailly Joëlle , Bailly Didier
Published: August 2024

Thanks to efficient computational capabilities, the numerical predictions of the helicopter rotor Blade Vortex Interaction noise (BVI) have reached an acceptable level of accuracy. Nevertheless, even if the experiment/computation comparisons are generally satisfactory, there still can remain some discrepancies in the comparisons. They can be caused by computational deficiencies or difficulties to accurately represent the actual test conditions. In the aim of reducing these discrepancies, it is possible to analyze the influence of key parameters, but it appears that approaching the solution may be unreachable due to the number of parameters to be tuned. The data assimilation technics were deemed appropriate to investigate their capabilities to improve the numerical predictions. The presented geometric methodology is particularly well adapted to determine the "best" combinations of parameters which allow an improved correlation between the HART-II experimental and ONERA numerical noise carpets, within a moderate computational cost.
The rural CPR outreach project: Medical students teach bystander CPR to secondary school students
Authors: Bene Watts Simona , McDonagh Erin , Richardson Wesley , Wilson Nicholas , Shi Kevin
Published: August 2024

Introduction:

Prompt bystander cardiopulmonary resuscitation (CPR) can double the chance of cardiac arrest survival. Rural and remote communities experience longer emergency service wait times and have lower rates of bystander-CPR compared to their urban counterparts. Our study addresses this disparity.

Methods:

We designed a 1.5-h free hands-only CPR course tailored to secondary school students in rural and remote communities taught by medical students. We evaluated our course using pre-test and post-test surveys.

Results:

We taught over 300 secondary students in 5 days. Less than one-third of students had previously taken a CPR course. We found that brief CPR instruction taught by medical students was effective in both improving students’ knowledge of CPR (t[528] = −26, P < 0.01) and perceived comfort in performing CPR (t[548] = −12, P < 0.01).

Conclusion:

CPR courses taught by medical students are effective, low cost, and may help address regional health care disparities. Teaching CPR to rural/remote communities may have secondary benefits such as promoting health care careers to rural youth. We encourage other health professional programmes to consider engaging students in CPR outreach projects.

Introduction:

Une réanimation cardio-pulmonaire rapide peut doubler les chances de survie en cas d’arrêt cardiaque. Les communautés rurales et éloignées connaissent des temps d’attente plus longs dans les services d’urgence et ont des taux plus faibles de RCP par rapport à leurs homologues urbains. Notre étude porte sur cette disparité.

Méthodes:

Nous avons conçu un cours de RCP pratique et gratuit d’une heure et demie, adapté aux élèves du secondaire des communautés rurales et isolées et dispensé par des étudiants en médecine. Nous avons évalué notre cours à l’aide d’enquêtes pré-test et post-test.

Résultats:

En 5 jours, nous avons enseigné à plus de 300 élèves du secondaire. Moins d’un tiers des élèves avaient déjà suivi un cours de RCP. Nous avons constaté qu’une brève formation à la RCP dispensée par des étudiants en médecine était efficace pour améliorer les connaissances des élèves en matière de RCP (t[528] = −26, P < 0,01) et la perception de leur aisance à pratiquer la RCP (t[548] = −12, P < 0,01).

Conclusion:

Les cours de RCP dispensés par les étudiants en médecine sont efficaces, peu coûteux et peuvent contribuer à lutter contre les disparités régionales en matière de soins de santé. L’enseignement de la RCP aux communautés rurales/éloignées peut avoir des avantages secondaires tels que la promotion des carrières dans le domaine de la santé auprès des jeunes ruraux. Nous encourageons d’autres programmes professionnels de santé à envisager d’engager leurs étudiants dans des projets de sensibilisation à la RCP.
Utility of Keystone Flap in Armory of Dermatosurgeons
Authors: Singh Abhinav , Singh Rohini , Chaturvedi Gaurav , Singh Malika , Singh RB
Published: August 2024

Purpose and Background:

To create awareness among dermatosurgeons about the versatility of keystone flaps in re-surfacing post-excisional small, medium and large skin defects.

Aims and Objectives:

Single-staged tension-free re-surfacing of various sized skin defects using keystone flap and to have least donor site morbidity, primary healing and maximum functional outcome.

Material and Methods:

This retrospective study was conducted, between October 2021 – January 2023 in Department of Plastic Surgery, PGIMS Rohtak, on 15 males and 1 female aged between 18 - 65 years. Sixteen Keystone flaps (type IIA n=13, Omega cum Sydney melanoma unit modification n=3) were utilized for resurfacing skin defects arising after excision of basal cell carcinoma (n=3) and benign hairy nevus (n=2) on cheek, basal cell carcinoma forehead (n=1), electric burns on deltoid (n=2), giant neurofibroma back (n=1), tattoo forearm (n=3), chronic non-specific granuloma thumb (n=2) and pilonidal sinus disease (n=2). Skin with maximum expansibility was chosen as donor site with utmost care of facial lines and its aesthetic subunits. Flaps were dissected all around preserving maximum number of hand-held Doppler-identified perforators in pedicular area. Sutures were removed on 10th to 15th post-operative day. Follow-ups ranged from 2 to 15 months.

Results:

None had wound dehiscence or loss of flap.

Conclusion:

Keystone flaps have defect-adaptive design, simple bio-geometry, technical simplicity, decreased downtime, cost effectivity and efficiency and can be designed to resurface post-excisional skin defect from head to toe with acceptable results, therefore should strongly be considered by dermatosurgeons while excising skin lesions.
“Little by little, I started feeling I am unable to handle my child alone” – Lived experiences of mothers with postpartum depression and anxiety
Authors: Sridhar Harikrupa , Kishore M. Thomas , Chandra Prabha S.
Published: August 2024

Background:

Anxiety and depression during the postpartum period can have a significant impact on mothers’ perceived sense of responsive caregiving, causing considerable distress. This association may be affected by mothers’ perception about social support. In the context of low-and-middle-income countries where prevalence rates of maternal mental illnesses are high and access to health care services is limited, informal supports become more relevant.

Aim:

The study aims to understand the lived experience of mothers who had postpartum depression or anxiety and their perceived distress related to infant care giving. It also explores the role of social support in the motherhood experience.

Methods:

Six mothers with postpartum depression or anxiety were interviewed to understand their experience of postpartum depression and/or anxiety and their perceptions about social support. The interviews were analyzed using a reflexive thematic analysis approach.

Results:

The thematic analysis revealed four themes, namely, (a) uncertainty and helplessness, (b) misattunement with the immediate family, (c) personal strength rooted in the family support system, and (d) other means of coping. Mothers with postpartum anxiety and depression can have emotional, informational, and tangible social support needs in the context of uncertainty and helplessness, which are associated with different challenges and barriers for infant care in the Indian context.

Conclusion:

Support from family members is viewed as a pillar of comfort and recovery for the mothers. At the same time, if it is not adequately attuned to the needs of the mother, it can become a major source of distress.
Psychometric attributes of the Dimensional Yale-Brown Obsessive-Compulsive Scale adapted in Bengali: A validation study in the Bengali-speaking population
Authors: Kundu Partha S. , Halder Arghya , Pal Amit K. , Ray Sagarika , Mondal Sayan
Published: August 2024

Introduction:

Obsessive-compulsive disorder (OCD) is characterized by underlying obsessions and yielding/nonyielding compulsions, which often leads to significant levels of distress for the individual. Recently, obsessive-compulsive symptoms have been grouped into various symptom dimensions. The Dimensional Yale-Brown Obsessive-Compulsive Scale (DY-BOCS) gives a comprehensive picture regarding symptom severity in each individual dimension of OCD, while also providing a global severity score.

Aims and Objectives:

The psychometric properties of the Bengali adaptation of DY-BOCS have been assessed in this study.

Material and Methods:

A cross-sectional study was performed on 80 individuals suffering from OCD as per the ICD-10 DCR criteria. The Bengali version of the DY-BOCS and other scales for OCD, anxiety, and depression were administered to all of them. Inter-rater reliability was assessed for 34 individuals, and agreement between self and clinician-rated version of DY-BOCS was studied for 60 individuals. Internal consistency for items in a particular dimension of DY-BOCS, convergent validity, and divergent validity were also assessed.

Results:

Internal consistency was found to be excellent (Cronbach’s α > 0.90 in all domains), and inter-rater reliability was found to be good to excellent for all the six dimensions of the DY-BOCS (intraclass correlation values >0.80 for aggressive and miscellaneous domains and >0.90 in all other domains). High correlation was found between self and clinician-rated versions of DY-BOCS for the age group 18–35 years, the highest correlations being found for the Contamination (r = 0.82) and Aggressive domains (r = 0.75), while it was found to decrease in the older age group. Convergent validity and divergent validity were found to be satisfactory.

Conclusion:

The psychometric attributes of the Bengali version of DY-BOCS appear to be satisfactory and thus can be reasonably administered to the population having Bengali as their mother tongue.
Efficacy of sequential primary motor and prefrontal cortices intermittent Theta burst stimulation in persistent somatoform PAIN disorder (TAP-PAIN): A randomized sham-controlled pilot trial
Authors: Joshi Shailja , Garg Shobit , Mishra Preeti , Dhyani Mohan , Tikka Sai Krishna
Published: August 2024

Aim:

There is a need to elucidate intermittent Theta burst stimulation (iTBS) as a novel treatment in persistent somatoform pain disorder (PSPD).

Methods:

Twenty patients were randomly allocated to active iTBS (n = 11) and sham iTBS (n = 9) and received 10 iTBS sessions, 2 sessions per day, sequentially to primary motor and dorsolateral prefrontal cortices for 5 days in a week. Each iTBS session comprised of 2 sec. per train of 10 bursts (3 pulses per burst at 50 Hz; total 30 pulses) and were given with a gap of 5 Hz, total of 20 trains, and 600 pulses. Visual Analogue Scale, Brief Pain Inventory and Global Pain Scale (GPS), Montgomery and Asberg Depression Rating Scale, Hamilton Anxiety Rating Scale - Anxiety, World Health Organization Quality-of-Life Scale-brief, and Pittsburgh Sleep Quality Index were applied at baseline, after last session, and at 2 weeks after last TBS session. Intention to treat analysis was conducted.

Results:

Both groups were comparable for baseline psychopathology scores including clinical variables like age (t = 0.865; P = 0.398), duration of illness (t = 1.600; P = 0.127), and motor threshold (t = 0.304; P = 0.765). On repeated measures ANOVA, a significant within-group time effect for VAS, BPI-Severity, BPI-Interference, BDI – II, MADRS, HAM-A, and WHOQOL- BREF was found for active and sham TBS groups, respectively. GPS scores had significant within-group (active) * time interaction (F = 11.651; P = .001; ηp2 = 0.538) and between-group * time interaction (F = 3.407; P = 0.044; ηp2 = 0.159). However, between-group * time effect interaction was lost after covariance (F = 1.726; P = 0.196; ηp2 = 0.110).

Conclusion:

No major adverse effects were reported. Our pilot trial concludes that safe therapeutic efficacy of iTBS in PSPD is inconclusive. Lower total number of sessions along with small sample size may limit the study findings.
Anticancer and bioactivity effect of the AraA-IL13 fusion protein on the glioblastoma cell line
Authors: Mehrab Rezvan , Sedighian Hamid , Sotoodehnejadnematalahi Fattah , Halabian Raheleh , Imanifooladi Abbas Ali
Published: August 2024

Background and purpose:

Glioblastoma (GBM) is an aggressive and malignant brain cancer with the highest mortality and low survival rates. To discover a more specific and efficient treatment for GBM, we synthesized and examined the cytotoxic effect of arazyme-interleukin-13 (Ara-IL13) fusion protein on GBM cells.

Experimental approach:

At first, the araA-IL13 chimeric gene in the pET28a (+) vector was designed and synthesized. After transformation into Escherichia coli BL21 (DE3), the chimeric gene was verified by colony polymerase chain reaction. Expression optimization and purification of the AraA-IL13 fusion protein was performed and subsequently evaluated by 10% SDS-PAGE. The protein was purified and concentrated using the Amicon® Ultra- 15 centrifugal filter unit. The presence of AraA-IL13 was investigated by the western blotting technique. The enzyme was evaluated for proteolytic activity after purification on skim milk agar. The cytotoxic effect of the AraA-IL13 fusion protein was evaluated by MTT assay on U251 and T98G cell lines in vitro.

Findings/Results:

The chimeric protein had no proteolytic activity on skim milk agar despite high expression. Furthermore, no cytotoxic effect of this fusion protein (up to 400 μg/mL) was observed on the U251 and T98G cell lines.

Conclusion and implications:

The lack of proteolytic activity and cytotoxic effect of AraA-IL13 may be due to the disruption of the three-dimensional structure of the protein or the large structure of the arazyme coupled with the ligand and the lack of proper folding of the arazyme to make the active site of the enzyme inaccessible.
Epidemiological Patterns, Risk Factors, and Outcomes in COVID-19 Patients from the Al-Hassa City of Saudi Arabia
Authors: Aleid Abdulsalam Mohammed , Ahmed Khadija Adel , Alhar Khalid Abdulrahim , Ma’ashi Esraa Yehea Hasan , Sonbul Yasseer Youssef , Alsuwat Khalid Jameel , Alfaraj Fatimah Baqer , Aljohani Ammar Mohammed , Alosaimi Hadeel Abdullah , Alshehri Abdulmohsen Ali , Aljarid Manar Yahya Saleh , Alalweni Bara Talal , Alghamdi Kheder Mabrook , Alqahtani Mansour Salem Ali , Almadani Noura Abdulla , Kharaba Ayman Mohammed
Published: August 2024

Background:

In the face of the ongoing global health crisis posed by COVID-19, it becomes imperative to understand the disease’s dynamics, particularly in specific regions. This study provides a detailed examination of the factors influencing mechanical ventilation (MV) duration among COVID-19 patients in an intensive care setting, focusing on a diverse patient cohort from the Al Hassa region of Saudi Arabia.

Objectives:

The primary aim of this study was to identify key demographic factors, clinical outcomes, and comorbidities that affect the duration of MV among intensive care unit (ICU) patients with COVID-19. This understanding is crucial for enhancing patient care and informing health-care strategies in the context of the pandemic.

Methods:

A retrospective cohort study was conducted involving patients diagnosed with COVID-19 and admitted to the ICU in the Al Hassa region. Data encompassed patient demographics, comorbidities, clinical outcomes, and MV duration. Statistical analyses were employed to explore the associations between these variables.

Results:

Our findings reveal significant associations between MV duration and various factors, including nationality, legal status, travel history, and comorbidities such as heart failure and immunocompromised status. These insights are instrumental in understanding the nuances of COVID-19 management in critical care.

Conclusion:

The study provides valuable insights into the determinants of MV duration in severe COVID-19 cases, emphasizing the need for individualized patient care approaches. It highlights the complexity of managing COVID-19 in ICU settings and underscores the importance of tailored health-care responses to this global health challenge, particularly in the Al Hassa region.
The prevalence, severity, and risk factors of erosive esophagitis in a Middle Eastern population
Authors: Alsahafi Majid , Salah Fatma , Mimish Hebah , Hejazi Mohammed , Alkhiari Resheed , Alkhowaiter Saad , Mosli Mahmoud
Published: August 2024

Background:

Erosive esophagitis (EE) is frequently present in patients with gastroesophageal reflux disease (GERD), some of which may not have GERD symptoms. The prevalence of EE in the Saudi population is unknown. In this study, we aimed to determine the prevalence and risk factors of EE among patients undergoing esophagogastroduodenoscopy (EGD).

Methods:

We retrospectively reviewed consecutive adults who underwent EGD at an academic tertiary care center. Clinical and endoscopic data were collected. The prevalence and severity of EE were determined. Multivariate regression analysis was used to identify risk factors for EE.

Results:

Records for 3230 patients were reviewed, of which 2805 were included in this study. The mean age was 48.6 ±18.6 years, and 1088 (38.7%) were male. Two hundred and twenty six (8%) patients underwent EGD for GERD-related indications. EE was noted in 309 (11%) patients and 58 (25.6%) with GERD-related indications. For patients with EE, the mean age was 49.2 ± 18.7 years, and 132 (42.7%) were males. LA Grade A esophagitis was the most common (53.9%), followed by grade B (29.6%). Among all patients, only EGD for GERD-related indications and hiatal hernia were significantly associated with EE on multivariate analysis [(aOR = 3.1, 95% CI 2.2–4.4, P < 0.01) and (aOR = 1.4, 95% CI 1.1–1.9, P < 0.01), respectively]. Age, gender, and body mass index were not associated with EE.

Conclusion:

In this large cohort, EE was present in 11% of patients who underwent EGD and in 25% of patients with GERD. EGD for GERD-related indications and hiatal hernia are independent risk factors for the presence of EE.
Assessment of cfDNA levels in saliva samples of stressed young adults: Preliminary study
Authors: Çelik Ekin , Köksal Miraç Berkay , Akbulut Hacı Mehmet , Aydın Selahattin Ata , Kurt Yiğit Emre , Okan Can , Çetinkaya Simay
Published: August 2024

Purpose: The aim of this pilot study was to examine the levels of cell-free DNA (cfDNA) in the saliva samples of second-year medical students before and after a stress-inducing event, exams.
Materials and Methods: Saliva samples were collected from 20 students, whose stress profiles were assessed using the DASS-21 scale, both before and after the exams. Cell-free DNA were isolated from these samples, and measured using spectrophotometry and automated electrophoresis system.
Results: Spectrophotometric analysis revealed a significant decrease in cfDNA levels in the saliva samples collected after the exams (p ≤ 0.05). This difference was confirmed by the automated electrophoresis system, particularly showing a reduction in cfDNA amounts in the 40-200 bp range with the reduction of stress (p ≤ 0.05).
Conclusion: Psychosocial stress affects the release of cell-free DNA. This study reports that the amount of cfDNA found in saliva samples significantly changes in relation to stress. This preliminary study suggests that cfDNA in saliva samples could potentially serve as a biological marker for stress in healthy individuals.
Effect of Mean Flow on the Transmission Loss of a Doubly Tuned Flow Reversal Muffler
Authors: Chetan Dayanand Gaonkar  , Thappaganadoddi Nagabushnasharma Sreenivasa
Published: August 2024

The same-end-inlet-outlet (SEIO) muffler, also referred to as a flow reversal muffler under flow conditions, features inlet and outlet pipes positioned on the same side of the chamber. Recently, a parametric expression has been developed to determine the end correction for double tuning of the SEIO muffler. This study extends the development of the SEIO muffler by experimentally validating the derived end correction expressions. Additionally, the tuning of the muffler is assessed with a mean flow using 3-D computational fluid dynamics, solving the linearized Navier-Stokes equation. This investigation explores the impact of flow conditions (Mach number 0.05 and 0.1) and temperature conditions (T = 733 K and 953 K) on the transmission loss (TL) of a doubly tuned muffler. The findings reveal that the muffler maintains its double tuning, even in the presence of mean flow at elevated temperatures, albeit with somewhat of a reduction in performance.
Synergistic Application of Particle Swarm Optimization and Gravitational Search Algorithm for Solar PV Performance Improvement
Authors: Aditya Sharma  , Dheeraj Kumar Palwalia
Published: August 2024

This study aims to optimize photovoltaic systems by developing a novel hybrid metaheuristic approach for maximum power point tracking (MPPT). The proposed method eclectically combines particle swarm optimization (PSO) and gravitational search algorithm (GSA) to overcome individual limitations and leverage complementary strengths. PSO, while surpassing in exploration, may suffer from premature convergence. GSA demonstrates strong exploitation capabilities but can struggle with slow convergence. A simulation model is developed to evaluate the hybrid algorithm’s performance in optimizing PV systems’ duty cycle. The approach utilizes the exploitation capabilities of PSO and GSA to navigate the search space effectively. Results demonstrate that the hybrid algorithm outperforms traditional techniques and standalone metaheuristics, achieving improved convergence time, faster settling time, and enhanced MPPT tracking efficiency. Under varying irradiance conditions, the proposed method consistently delivers higher power generation and improved overall PV system efficiency, offering a promising solution for optimizing PV systems and maximizing energy generation.
SEMIOTIC ANALYSIS OF BULLYING IN THE PYRAMID GAME SERIES ON SOCIAL MEDIA X
Authors: Nurlatifah Putri Indah , Zahra Tineziany , Nurfalah Farida
Published: August 2024

Bullying is one of the social deviant behaviors that often occur in all environments, including schools. This study aims to determine the description of bullying and the meaning of signs contained in the series “Pyramid Game” on social media X through semiotics using Charles Sanders Pierce's theory. Each scene in this drama is decomposed into signs, objects, and interpretations that describe the dynamics of bullying behavior. The method used is descriptive qualitative, with a semiotic approach to analyze and explain how the meaning of signs regarding bullying occurs. The results of the analysis show various forms of bullying, ranging from physical violence, threats, sexual harassment, to social exclusion. Teachers have a major role in creating a safe, comfortable, and moral learning environment. Based on this research, it can be concluded that the importance of awareness and action to prevent and overcome bullying behavior, both in the school environment and society at large. Netizens responding to these scenes provide a deep understanding of the importance of awareness about negative behavior: bullying.
Analisis Penerapan Kode Etik Penagihan pada Fintech P2p Lending dalam Perspektif Perlindungan Konsumen (Studi Kasus Layanan Pinjaman Online Adakami)
Authors: Sudiro Amoury Adi , Machmud Aris , Nurhisyam Feby
Published: August 2024

The emergence of online loan applications provides a new practical and unsecured option in accounts receivable agreements, allowing many people to use this service. However, the thing that stands out in online loans is related to the behavior of collection officers from fintech P2P Lending companies by not applying ethics and consumer protection principles such as billing cases on the AdaKami application that commit terror, intimidation and threats so that they are detrimental to consumers as users of the application. The purpose of this study is to determine the application of a billing code of ethics that guarantees legal certainty in fintech P2P Lending and legal protection for victims who experience losses for the occurrence of the collection in question. This research uses normative juridical law research methods with a statutory approach (statute approach), analytical approach (analytical approach), and case approach (case approach). The main data collection is carried out by looking at several literatures, undergraduate scientific papers, and laws and regulations to obtain secondary data. The results showed that the application of the billing code of ethics in fintech P2P Lending is still not optimal due to the lack of legal regulations that can adequately protect consumers from actions taken by fintech P2P Lending. Better regulation and legal coordination between relevant parties are needed to enforce the law and protect consumer rights from violations committed by fintech P2P lending companies.