bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular identification of triticale introgression lines carrying leaf rust resistance genes transferred from Aegilops kotschyi Boiss. and Ae. tauschii Coss
Authors: Kwiatek Michał T. , Belter Jolanta , Ulaszewski Waldemar , Skowrońska Roksana , Noweiska Aleksandra , Wiśniewska Halina
Published: May 2021

Triticale (× Triticosecale Wittmack) is a commercial hybrid harboring wheat (Triticum sp.) and rye (Secale cereale L.) genomes. The limited genetic diversity of this crop resulted in the collapse of fungal disease resistance. Leaf rust disease, caused by Puccinia triticina Eriks., is reported to reduce the triticale yield significantly (more than 30%). There is a need to enlarge the genetic variability of this crop including leaf resistance genes. The main aim of this research was to evaluate the leaf rust resistance of the offspring of translocation lines of triticale carrying chromatin of Ae. tauschii and Ae. kotschyi. A reaction of seedlings of 200 plants of two triticale-Aegilops translocation lines (Bogo-2Dt.2R and Sekundo-2Sk.2R) was compared after inoculation with a natural mixture of P. triticina races, specific to triticale in controlled condition. Before inoculation, each plant was screened using molecular cytogenetics and molecular markers linked to leaf rust resistance genes. The presence of Aegilops chromosome segments was confirmed using genomic in situ hybridization (GISH). Lr39 and Lr54 leaf rust resistance genes were identified using Xgdm35 and S14 molecular markers, respectively. After inoculation, a significant improvement of resistance severity was observed in Sekundo-2Sk.2R in comparison with triticale cv. Sekundo plants. The resistance level of Bogo-2Dt.2R did not differ compared with triticale cv. Bogo plants. It was shown that Lr39 gene did not increase the leaf rust resistance level of triticale cv. Bogo.
Some species flourish when many do not: a pattern in data on ecological communities
Authors: Straatsma Gerben , Peeters Edwin T. H. M. , van Nes Egbert H.
Published: May 2021

Patterns in species × sample tables of communities depend above all on the organisms of the data sets and the conditions involved. Patterns that surpass individual sets are of special interest. Our question, looking for a shared pattern in 12 sets, is if relative abundances among species are independent of the sample, or formulated alternatively, if species have abundances that are correlated with total abundances over samples. For exploration we study the overdispersion/aggregation of the data. A relatively high variation in the total abundances of samples is noticed, indicating an effect of environmental variation. Overdispersion imposes constraints on the accommodation of relatively high abundance values to samples with a relatively low total abundance. The null hypothesis of ‘no association’ is modelled by permutation/resampling of the data at the level of the individual. A correlation study of actual and permuted sets is performed. All actual sets contain a significant number of species that defy our question. These species flourish when many do not. The relation of our question with issues in theoretical ecology, such as the assumption of a neutral effect of environmental conditions and/or of neutral characteristics of species, is discussed.
An alternative approach to evaluate fuel/air mixing quality
Authors: Jiang L.-Y.
Published: May 2021

A practical method to evaluate quantitatively the uniformity of fuel/air mixing is essential for research and development of advanced low-emission combustion systems. Typically, this is characterised by measuring an unmixedness parameter or a uniformity index. An alternative approach, based on the fuel/air equivalence ratio distribution, is proposed and demonstrated in a simple methane/air venturi mixer. This approach has two main advantages: it is correlated with the fuel/air mixture combustion temperature, and the maximum temperature variation caused by fuel/air non-uniformity can be estimated. Because of these, it can be used as a criterion to check fuel/air mixing quality, or as a target for fuel/air mixer design with acceptable maximum temperature variation. For the situations where the fuel/air distribution non-uniqueness issue becomes important for fuel/air mixing check or mixer design, an additional statistical supplementary criterion should also be used.
Investigating the Association between Aortic Arch Variants and Intracranial Aneurysms
Authors: Salehi Fateme , Nadeem Ibrahim M. , Kwan Benjamin Y. M. , Johnson Peter B. , Pelz David M. , Lee Donald , Sharma Manas
Published: May 2021

Background:

There is an association between anterior cerebral artery vessel asymmetry and anterior communicating artery aneurysm, presumably based on flow dynamics. The purpose of this study is to investigate the potential relationship between aortic arch branching patterns and incidence of intracranial aneurysm.

Methods:

This study included patients scanned over 1 year at our tertiary care center who underwent high-resolution imaging (computed tomography angiography or digital subtracted angiogram) of the head and neck arteries, aortic arch, and superior mediastinum. Exclusion criteria included patients with suboptimal images. Patient age, gender, aortic arch branching pattern, and the presence, location, and number of aneurysms were documented.

Results:

Among the 1082 patients analyzed, 250 (23%) patients had a variant aortic arch branching pattern, 22 (8.8%) of whom had aneurysms. There were 104 patients with 126 aneurysms, with majority of patients with normal aortic arch branching pattern (n = 82, 79%). The most common variant was a common origin of the left common carotid artery and brachiocephalic trunk with or without direct origin of the left vertebral artery. Twenty-two patients with aneurysms had an aberrant aortic arch (21%), compared to 232 patients without an aneurysm (24%). Fischer exact test showed no statistically significant difference between the incidence of aneurysm with different aortic arch variant groups (two-tailed p-value = 0.715).

Conclusion:

To our knowledge, this is the first study to examine the association between aortic arch branching patterns and incidence of intracranial aneurysm. No significant association was found between aortic arch branching pattern and the incidence of intracranial aneurysm.
Novel constant-cladding tapered-core ytterbium-doped fiber for high-power fiber laser oscillator
Authors: Ye Yun , Lin Xianfeng , Xi Xiaoming , Shi Chen , Yang Baolai , Zhang Hanwei , Wang Xiaolin , Li Jinyan , Xu Xiaojun
Published: May 2021

Power scaling based on traditional ytterbium-doped fibers (YDFs) is limited by optical nonlinear effects and transverse mode instability (TMI) in high-power fiber lasers. Here, we propose a novel long tapered fiber with a constant cladding and tapered core (CCTC) along its axis direction. The tapered-core region of the fiber is designed to enhance the stimulated Raman scattering (SRS) threshold and suppress higher-order mode resonance in the laser cavity. The CCTC YDF was fabricated successfully with a modified chemical vapor deposition (MCVD) method combined with solution doping technology, which has a cladding diameter of 400 μm and a varying core with a diameter of ~24 μm at both ends and ~31 μm in the middle. To test the performance of the CCTC fiber during high-power operation, an all-fiber laser oscillator based on a CCTC YDF was investigated experimentally. As a result, a maximum output power of 3.42 kW was achieved with an optical-to-optical efficiency of 55.2%, although the TMI effect was observed at an output power of ~3.12 kW. The measured beam quality (M2 factor) was ~1.7, and no sign of the Raman component was observed in the spectrum. We believe that CCTC YDF has great potential to simultaneously mitigate the SRS and TMI effects, and further power scaling is promising by optimizing the structure of the YDF.
Surveillance of adverse drug events associated with tocilizumab in hospitalized veterans with coronavirus disease 2019 (COVID-19) to inform patient safety and pandemic preparedness
Authors: Datta Rupak , Barrett Alexis , Burk Muriel , Salone Cedric , Au Anthony , Cunningham Francesca , Fisher Ann , Dembry Louise Marie , Akgün Kathleen M.
Published: May 2021

We evaluated adverse drug events (ADEs) by chart review in a random national sample of 428 veterans with coronavirus disease 2019 (COVID-19) who received tocilizumab (n = 173 of 428). ADEs (median time, 5 days) occurred in 51 of 173 (29%) and included hepatoxicity (n = 29) and infection (n = 13). Concomitant medication discontinuation occurred in 22% of ADE patients; mortality was 39%.
Aristocracy Must Advertise: Repurposing the Nobility in Interwar British Fiction
Authors: Mayhall Laura E. Nym
Published: May 2021

In the interwar years, authors Dorothy L. Sayers, Ngaio Marsh, and Margery Allingham wrote popular detective fiction that explored possible roles for the aristocracy in an age of universal suffrage. Critics have seen these novels as nostalgic encomia for hierarchy and tradition. This article argues that they should be seen instead as part of a larger trend in interwar fiction that sought to make connections between aristocracy, national identity, and social cohesion. Far from celebrating an imagined idyllic past, these novels suggested possibilities for the continuing relevance of the nobility to the upholding of justice, and indeed, to the success of British democracy.
Associated factors with dietary patterns among children under 2 years of age: a study in childcare centres and homes of South Brazil
Authors: Guedes Juliana R. D. , Höfelmann Doroteia A. , Madruga Fernanda P. , de Oliveira Elaine C. V. , de Cerqueira Mônica M. O. , Lobo Alline C. S. , Almeida Cláudia C. B.
Published: May 2021

Identifying dietary patterns in different environments attended by children is relevant to guide public politics. The aim of this study was to analyse the factors associated with dietary patterns of children under 2 years of age in childcare centres and at homes. This transversal study was enrolled in municipal childcare centres of Guaratuba, Paraná, Brazil. Food consumption data from 256 children were obtained by the food record method. From the consumption data, four dietary patterns were identified by factor analysis using the principal component method in each environment. ‘Traditional’ patterns were observed in both environments; the ‘less healthy’ pattern was found only at homes. Other patterns identified in childcare centres include ‘snacks’, ‘nutritive’ and ‘pasta and meats’; at homes, it was possible to identify patterns such as ‘milk and cereals’ and ‘mixed’. Children over 12 months presented higher scores for all the patterns in both environments. Obese children had lower scores for all the patterns in childcare centres. There was an association between maternal age below 21 years and higher adherence to a ‘less healthy’ pattern, maternal level of education less than 8 years and lower adherence to the ‘mixed’ pattern and lower familiar income per capita and higher adherence to the ‘snacks’ and ‘traditional’ patterns in childcare centres. In conclusion, adherence to dietary patterns was associated with socio-economic, demographic variables and nutritional status and further studies are needed, especially those with a longitudinal design, enabling the monitoring of dietary patterns.
Changes in floodplain geo-ecology in the Belgian loess belt during the first millennium AD
Authors: Broothaerts Nils , Swinnen Ward , Hoevers Renske , Verstraeten Gert
Published: May 2021

Variation in human activities has greatly impacted the processes and intensities of erosion, sediment transport and storage throughout the Late Holocene, and many lowland rivers around the world have responded to these variations. Although this long-term process–response relationship has been established before, the effects of short-term (c.200-year) changes in human impact on lowland rivers are less well studied. Here, we followed an integrated approach whereby observations of floodplain changes are evaluated against detailed data on human impact for three lowland rivers in the Belgian loess belt: Dijle, Mombeek and Gete rivers. Pollen data were used to reconstruct changes in local and regional vegetation and to calculate human impact scores. Corings along transects and a database of c.160 radiocarbon ages were used to reconstruct geomorphic changes in the river valleys. Our results show a decrease in human impact between 200 and 800 AD, which can be related to the decreased population density in Europe during the first millennium AD. During this period, forests in the studied catchments regenerated, soil erosion decreased, hillslope–floodplain connectivity decreased due to the regeneration of valley-side vegetation barriers, and sediment input in the floodplain decreased. A reaction to this decreased human impact can be observed in the river valleys during the first millennium AD, with a regrowth of the alder carr forest and an increase in the organic matter content of the alluvial deposits with a local reactivation of peat growth. The observed trajectories of Belgian river valleys during the first millennium AD provide more insight into the sensitivity of these river valleys to short-term variations in human impact. These results can in turn be used to better estimate the effects of future changes in the catchments on the fluvial system.
Ethnic Boundaries and Territorial Borders: On the Place of Lezgin Irredentism in the Construction of National Identity in Azerbaijan
Authors: Sayfutdinova Leyla
Published: May 2021

The Lezgin irredentist movement is one of the less-studied national movements in the post-Soviet space, despite affecting the strategically important Russian-Azerbaijani borderlands and the bordering process between the two post-Soviet states. This article aims to fill this gap and to examine the impact of the Lezgin national movement on the development of territorial nationalism in early post-Soviet Azerbaijan. Based on the analysis of media publications in three Azerbaijani newspapers between 1992 and 1996, I argue that the movement contributed to consolidating the territorial vision of the Azerbaijani nation as incorporating groups historically settled in this territory. While media coverage stressed friendship between ethnic Azerbaijanis and Lezgins, the responsibility for secessionist claims was placed on external forces, particularly Russia and Armenia. In the long term, this framing led to the securitization of ethnic minority activism as a major threat to Azerbaijani statehood.
The Ottoman Empire, the United States, and the legal battle over extradition: the “Kelly affair”
Authors: Kamay Berna
Published: May 2021

This article examines extradition in nineteenth-century Ottoman diplomacy by exploring an illustrative legal conflict between the Ottoman Empire and the United States. The Kelly affair, which revolved around the murder of an Ottoman subject by an American sailor in Smyrna (Izmir) in 1877, sparked a diplomatic dispute that lasted for several decades. The controversy stemmed from conflicting interpretations of the treaty of commerce signed in 1830. The inability to reach a consensus pushed the parties to resort to the 1874 Extradition Treaty, which was the only official Ottoman extradition agreement. The Kelly affair poignantly illustrates how extradition, an issue of international law that touched on territorial jurisdiction and subjecthood, was a complicated and ill-defined matter when addressed in practice. By investigating the confrontation between the Ottoman Empire and the USA, both putative secondary powers on the international stage at the time, this article challenges the existing historical narratives on interimperial relations that highlight Europe as the locus of power and agency. Even though ad hoc political actions overshadowed the binding force of the treaty text, it demonstrates how both governments adopted a political strategy that moved beyond the intrinsic arguments and logic of the capitulations to embrace a novel legal discourse.
MIDDLE BRONZE AGE JERUSALEM: RECALCULATING ITS CHARACTER AND CHRONOLOGY
Authors: Regev Johanna , Gadot Yuval , Roth Helena , Uziel Joe , Chalaf Ortal , Ben-Ami Doron , Mintz Eugenia , Regev Lior , Boaretto Elisabetta
Published: May 2021

The following paper presents the results of radiocarbon (14C) dating of Middle Bronze Age (MB) contexts in Jerusalem. The dates, sampled with microarchaeology methods from three different locations along the eastern slopes of the city’s ancient core, reveal that Jerusalem was initially settled in the early phases of the period, with public architecture first appearing in the beginning of the 19th century BC and continued to develop until the 17th century BC. At that time, a curious gap in settlement is noted until the 16th century BC, when the site is resettled. The construction of this phase continued into the early 15th century BC. The dates presented are discussed in both the site-level, as well as their far-reaching implications regarding MB regional chronology. It is suggested here that the high chronology, dating the Middle Bronze Age between 2000 and 1600 BC is difficult to reconcile with dates from many sites. In contrast, a more localized chronology should be adopted, with the Middle Bronze Age continuing into the early 15th century BC in certain parts of the southern Levant, such as the region of Jerusalem.
BUILDING HIGH-PRECISION AMS14C BAYESIAN MODELS FOR THE FORMATION OF PERI-ABANDONMENT DEPOSITS AT BAKING POT, BELIZE
Authors: Hoggarth Julie A , Culleton Brendan J , Awe Jaime J , Helmke Christophe , Lonaker Sydney , Davis J Britt , Kennett Douglas J
Published: May 2021

Deposits linked to abandonment have been widely recorded across the Maya lowlands, associated with the final activities occurring in ceremonial areas of Classic Maya centers. Various models have been applied to explain the activities that lie behind the formation of these contexts, including those linked to rapid abandonment (e.g., warfare) and others focused on more protracted events (termination rituals, and/or pilgrimages). Here, we assess Bayesian models for three chronological scenarios of varying tempo to explain the formation of peri-abandonment deposits at Baking Pot, Belize. Using stratigraphic information from these deposits, hieroglyphic dates recovered on artifacts, and direct dates on human skeletal remains and faunal remains from distinct layers in three deposits in Group B at Baking Pot, we identify multiple depositional events that spanned the eighth to ninth centuries AD. These results suggest that the processes associated with the breakdown of institutionalized rulership and its command of labor to construct and maintain ceremonial spaces were protracted at Baking Pot, with evidence for the final depositional activity dated to the mid-to-late ninth century. This interval of deposition was temporally distinct from the earlier deposition(s) in the eighth century. Together, these data offer a detailed view of the end of the Classic period at Baking Pot, in which the ceremonial spaces of the site slowly fell into disuse over a period of more than a century.
Effects of crustacean hyperglycaemic hormone RNA interference on regulation of glucose metabolism in Litopenaeus vannamei after ammonia-nitrogen exposure
Authors: Zhang Xin , Pan Luqing , Tong Ruixue , Li Yufen , Si Lingjun , Chen Yuanjing , Wu Manni , Wang Qiaoqiao
Published: May 2021

To unveil the adaptation of Litopenaeus vannamei to elevated ambient ammonia-N, crustacean hyperglycaemic hormone (CHH) was knocked down to investigate its function in glucose metabolism pathway under ammonia-N exposure. When CHH was silenced, haemolymph glucose increased significantly during 3–6 h, decreased significantly during 12–48 h and recovered to the control groups’ level at 72 h. After CHH knock-down, dopamine (DA) contents reduced significantly during 3–24 h, which recovered after 48 h. Besides, the expressions of guanylyl cyclase (GC) and DA1R in the hepatopancreas decreased significantly, while DA4R increased significantly. Correspondingly, the contents of cyclic AMP (cAMP), cyclic GMP (cGMP) and diacylglycerol (DAG) and the expressions of protein kinase A (PKA), protein kinase G (PKG), AMP active protein kinase α (AMPKα) and AMPKγ were significantly down-regulated, while the levels of protein kinase C (PKC) and AMPKβ were significantly up-regulated. The expressions of cyclic AMP response element-binding protein (CREB) and GLUT2 decreased significantly, while GLUT1 increased significantly. Moreover, glycogen content, glycogen synthase and glycogen phosphorylase activities in hepatopancreas and muscle were significantly increased. Furthermore, the levels of key enzymes hexokinase, pyruvate kinase and phosphofructokinase in glycolysis (GLY), rate-limiting enzymes citrate synthase in tricarboxylic acid and critical enzymes phosphoenolpyruvate carboxykinase, fructose diphosphate and glucose-6-phosphatase in gluconeogenesis (GNG) were significantly decreased in hepatopancreas. These results suggest that CHH affects DA and then they affect their receptors to transmit glucose metabolism signals into the hepatopancreas of L. vannamei under ammonia-N stress. CHH acts on the cGMP-PKG-AMPKα-CREB pathway through GC, and CHH affects DA to influence cAMP-PKA-AMPKγ-CREB and DAG-PKC-AMPKβ-CREB pathways, thereby regulating GLUT, inhibiting glycogen metabolism and promoting GLY and GNG. This study contributes to further understand glucose metabolism mechanism of crustacean in response to environmental stress.
Political Equality and Substantive Representation by Interest Groups
Authors: Boräng Frida , Naurin Daniel
Published: May 2021

The interest group literature has long struggled with how to empirically approach the normative idea of a non-biased group system. While most previous attempts have focused on the descriptive representation of different types of groups, this article argues that substantive representation of citizens' attitudes is closer to the democratic principle of equal effective participation. It develops a methodological approach that captures substantive representation with respect to agenda priorities and policies by surveying interest groups on how much time they spend on lobbying in different policy areas, and in which direction they lobby on salient policy issues. The responses are compared with opinion data to estimate the level of political (in)equality. The findings from the case of Sweden – where relatively high levels of equality would be expected, but striking levels of inequality based on socio-economic status are instead found – highlight the perseverance of what Schattschneider once called the upper-class bias of the pressure system.
The Political Implications of Personality in Canada
Authors: Bergeron Thomas , Galipeau Thomas
Published: May 2021

Few studies have focused on the Canadian context to examine the political impacts of personality. Even though the Canadian Election Study (CES) has measured the Big Five personality traits since 2011, very few studies have taken advantage of this data to assess personality's political role among the Canadian electorate. Using CES data from the three latest elections (2011, 2015 and 2019), we first explore how reliable the measurement of personality is. Except for agreeableness in 2015, the correlations across the personality items are similar to what is typically found in the literature. We next examine how personality affects ideology and partisan identity in the Canadian context. We show that a two-dimensional measurement of ideology refines our understanding of the impacts of personality on ideology. The findings also suggest that personality plays an essential role in forming ideology in Canada but has a limited impact on partisanship.
A Copper Still and the Making of Rum in the Eighteenth-Century Atlantic World
Authors: Zahedieh Nuala
Published: May 2021

This article focuses on a copper still transported from London to the Mesopotamia estate in Jamaica and used to convert waste sugar products into rum, one of the many New World intoxicants which transformed British consumption patterns in the early modern period. Much has been written about the consumer revolution which allowed these commodities to be absorbed into everyday lives but less interest has been shown in the producer revolution needed to get the goods to market. The labour, skills, and materials embodied in the production and use of the copper still highlight how slave production of rum was integrated into a steadily advancing industrial capitalism linking dispersed sites and workers on both sides of the Atlantic. Rum production was a collaborative effort in which Caribbean plantations were inextricably chained to the local, regional, and international economies, and it involved adaptations in skills, tools, and techniques which were incorporated into Britain's long, slow industrial revolution.
State Formation in Korea and Japan, 400–800 CE: Emulation and Learning, Not Bellicist Competition
Authors: Huang Chin-Hao , Kang David C.
Published: May 2021

State formation occurred in Korea and Japan 1,000 years before it did in Europe, and it occurred for reasons of emulation and learning, not bellicist competition. State formation in historical East Asia occurred under a hegemonic system in which war was relatively rare, not under a balance-of-power system with regular existential threats. Korea and Japan emerged as states between the fifth and ninth centuries CE and existed for centuries thereafter with centralized bureaucratic control defined over territory and administrative capacity to tax their populations, field large militaries, and provide extensive public goods. They created these institutions not to wage war or suppress revolt: the longevity of dynasties in these countries is evidence of both the peacefulness of their region and their internal stability. Rather, Korea and Japan developed state institutions through emulation and learning from China. The elites of both copied Chinese civilization for reasons of prestige and domestic legitimacy in the competition between the court and the nobility.
The effects of denatured major bovine whey proteins on the digestive tract, assessed by Caco-2 cell differentiation and on viability of suckling mice
Authors: Kobayashi Chihiro , Inagaki Mizuho , Nohara Midori , Fukuoka Mayuko , Xijier  , Yabe Tomio , Kanamarua Yoshihiro
Published: May 2021

Alpha-lactalbumin (α-LA) and β-lactoglobulin (β-LG) are contained in bovine milk whey. Chemical and physical treatments are known to alter the conformation of these proteins and we have previously reported that α-LA denatured with trifluoroethanol (TFE) and isolated from sterilized market milk inhibited the growth of rat crypt IEC-6 cells. In the present study, we aimed to evaluate the effects of TFE-treated α-LA and β-LG on cell growth using cultured intestinal cells and on their safety using a suckling mouse model. First, we investigated the effect of the TFE-treated whey proteins on human colonic Caco-2 cells at various differentiation stages. In the undifferentiated stage, we assessed cell growth by a water-soluble tetrazolium-1 method. The native whey proteins enhanced cell proliferation, whereas the TFE-treated whey proteins strongly inhibited cell growth. We investigated cell barrier function in the post-differentiated stage by measuring transepithelial electrical resistance (TER). Not only native but also the TFE-treated whey proteins increased TER. Next, we evaluated whether the TFE-treated α-LA and β-LG have adverse effects on healthy suckling mice. No mice given by the TFE-treated samples showed any adverse symptoms. We also performed a safety test using a human rotavirus infected gastrointestinal disease suckling mice model. Even the TFE-treated whey proteins appeared to prevent the development of diarrheal symptoms without any adverse effects. Although we cannot know the effect of long-term ingestion of denatured whey proteins, these results suggest that they have no adverse effects on differentiated intestinal cells and digestive tract, at least in short-term ingestion.
Why knowledge is the best way to reduce the risks associated with raw milk and raw milk products
Authors: Fagnani Rafael , Nero Luis Augusto , Rosolem Carla Prado
Published: May 2021

In an age of flexible conditions about mandatory milk pasteurisation, this opinion-based research reflection supports the view that the knowledge and the awareness of milk-borne infections are key requirements to decrease the risks associated with raw milk. Providing an analysis of the current potential risks related to consumption of raw milk and raw milk products, we discuss the main reasons to continue to be vigilant about milk-borne pathogens and the current scenario in relation to the formal and clandestine sale of raw milk. Finally, we select some highly effective strategies to reduce the risks associated with raw milk in food services. Regardless of whether a country regulation allows or prohibits the trade of raw milk and its products, this is not the time to be negligent.
Regenerative medicine for end-stage fibrosis and tissue loss in the upper aerodigestive tract: a twenty-first century review
Authors: Green F R , Shubber N M , Koumpa F S , Hamilton N J I
Published: May 2021

Objective

This review assesses regenerative medicine of the upper aerodigestive tract during the first two decades of the twenty-first century, focusing on end-stage fibrosis and tissue loss in the upper airways, salivary system, oropharynx and tongue.

Method

PubMed, Embase, Google Scholar, Cochrane Library, Medline and clinicaltrials.org were searched from 2000 to 2019. The keywords used were: bioengineering, regenerative medicine, tissue engineering, cell therapy, regenerative surgery, upper aerodigestive tract, pharynx, oropharynx, larynx, trachea, vocal cord, tongue and salivary glands. Original studies were subcategorised by anatomical region. Original human reports were further analysed. Articles on periodontology, ear, nose and maxillofacial disorders, and cancer immunotherapy were excluded.

Results

Of 716 relevant publications, 471 were original studies. There were 18 human studies included, within which 8 reported airway replacements, 5 concerned vocal fold regeneration and 3 concerned salivary gland regeneration. Techniques included cell transplantation, injection of biofactors, bioscaffolding and bioengineered laryngeal structures.

Conclusion

Moderate experimental success was identified in the restoration of upper airway, vocal fold and salivary gland function. This review suggests that a shift in regenerative medicine research focus is required toward pathology with a higher disease burden.
Please Like This Paper
Authors: McDonald Lucy
Published: May 2021

In this paper I offer a philosophical analysis of the act of ‘liking’ a post on social media. First, I consider what it means to ‘like’ something. I argue that ‘liking’ is best understood as a phatic gesture; it signals uptake and anoints the poster’s positive face. Next, I consider how best to theorise the power that comes with amassing many ‘likes’. I suggest that ‘like’ tallies alongside posts institute and record a form of digital social capital. Finally, I consider whether ‘likes’ have ultimately improved online discourse. I argue that while the ‘liking’ function itself is relatively innocuous, public ‘like’ tallies introduce a corrosive motivation to online communication. By making the prospect of increased social capital perpetually salient to us, they encourage us to prioritise high levels of engagement over meaningful engagement.
Surveillance Capitalism: a Marx-inspired account
Authors: Venkatesh Nikhil
Published: May 2021

Some of the world's most powerful corporations practise what Shoshana Zuboff (2015; 2019) calls ‘surveillance capitalism’. The core of their business is harvesting, analysing and selling data about the people who use their products. In Zuboff's view, the first corporation to engage in surveillance capitalism was Google, followed by Facebook; recently, firms such as Microsoft and Amazon have pivoted towards such a model. In this paper, I suggest that Karl Marx's analysis of the relations between industrial capitalists and workers is closely analogous to the relations between surveillance capitalists and users. Furthermore, three problematic aspects of industrial capitalism that Marx describes – alienation, exploitation and accumulation – are also aspects, in new forms, of surveillance capitalism. I draw heavily on Zuboff's work to make these parallels. However, my Marx-inspired account of surveillance capitalism differs from hers over the nature of the exchange between users and surveillance capitalists. For Zuboff, this is akin either to robbery or the gathering of raw materials; on the Marx-inspired account it is a voluntary sale. This difference has important implications for the question of how to resist surveillance capitalism.
Income poverty among children with a disability in Belgium: the interplay between parental employment, social background and targeted cash support
Authors: VINCK JULIE
Published: May 2021

Previous research has shown a clear link between childhood disability and child poverty. This is related to the fact that parents of disabled children (1) need to provide more care, which impedes their employment participation; and (2) more often belong to disadvantaged social categories. However, the adverse relationship between childhood disability and child poverty can be cushioned by cash support systems. Hitherto, the literature lacks insight into how the receipt of different cash support systems is related to parental employment and social background, and what joint role these three factors play in understanding the poverty risk of these children. To fill this gap, a case study on Belgium is performed using unique and large-scale register data. The results show that disabled children have a lower income poverty risk than non-disabled children, even when parental employment and social background are taken into account. This can be explained by the targeted cash support disabled children receive. However, previous research showed that a substantial group of disabled children does not receive the benefit. Hence, more could be achieved if the non-take-up would be addressed, in particular among the most vulnerable children.
Energy optimal motion planning of a 14-DOF biped robot on 3D terrain using a new speed function incorporating biped dynamics and terrain geometry
Authors: Kumar Jitendra , Dutta Ashish
Published: May 2021

In this paper, a new method is proposed to find a feasible energy-efficient path between an initial point and goal point on uneven terrain and then to optimally traverse the path. The path is planned by integrating the geometric features of the uneven terrain and the biped robot dynamics. This integrated information of biped dynamics and associated cost (energy) for moving toward the goal point is used to define the value of a new speed function at each point on the discretized surface of the terrain. The value is stored as a matrix called the dynamic transport cost (DTC). The path is obtained by solving the Eikonal equation numerically by fast marching method (FMM) on an orthogonal grid, by using the information stored in the DTC matrix. One step of walk on uneven terrain is characterized by 10 footstep parameters (FSPs); these FSPs represent the position of swinging foot at the starting and ending time of the walk, orientation, and state (left or right) of support foot. A walking dataset was created for different walking conditions (FSPs), which the biped robot is likely to encounter when it has to walk on the uneven terrain. The corresponding energy optimal hip and foot trajectory parameters (HFTPs) are obtained by optimization using a genetic algorithm (GA). The created walk dataset is generalized by training a feedforward neural network (NN) using the scaled conjugate gradient (SCG) algorithm. The Foot placement planner gives a sequence of foot positions and orientations along the obtained path, which is followed by the biped robot by generating real-time optimal foot and hip trajectories using the learned NN. Simulation results on different types of uneven terrains validate the proposed method.
Revisiting the Acquisition of Onset Complexity: Affrication in Québec French
Authors: GUZZO Natália Brambatti
Published: May 2021

I investigate the acquisition of affrication in Québec French (QF), where affricates are in complementary distribution with coronal stops, being realized before high front vowels and glides. Previous research on other languages shows that affricates are acquired before branching onsets, which supports the idea that complexity at the level of the segment is acquired before complexity at the level of the syllable (Lleó & Prinz, 1997). In contrast, I hypothesize that affricates are acquired after branching onsets in QF, as learners are required to understand the constraints on their distribution. I examine longitudinal data from two QF-speaking children for whom the acquisition of branching onsets has been previously analyzed (Rose, 2000). Results show that affricates are indeed acquired after branching onsets, consistent with the hypothesis. Overapplication errors indicate that children make generalizations about the phonological constraints on affrication from an early age, which is expected for the acquisition of rules.
Epidemiological assessment of 5598 brucellosis inpatients in Spain (1997–2015)
Authors: Rodríguez-Alonso Beatriz , Almeida Hugo , Alonso-Sardón Montserrat , Velasco-Tirado Virginia , Romero-Alegria Ángela , Pardo-Lledias Javier , López-Bernus Amparo , Pérez Arellano José Luis , Belhassen-García Moncef
Published: May 2021

Brucellosis remains one of the main zoonoses worldwide. Epidemiological data on human brucellosis in Spain are scarce. The objective of this study was to assess the epidemiological characteristics of inpatient brucellosis in Spain between 1997 and 2015. A retrospective longitudinal descriptive study was performed. Data were requested from the Health Information Institute of the Ministry of Health and Equality, which provided us with the Minimum Basic Data Set of patients admitted to the National Health System. We also obtained data published in the System of Obligatory Notifiable Diseases. A total of 5598 cases were registered. The period incidence rate was 0.67 (95% CI 0.65–0.68) cases per 100 000 person-years. We observed a progressive decrease in the number of cases and annual incidence rates. A total of 3187 cases (56.9%) came from urban areas. The group most at risk comprised men around the fifth decade of life. The average (±s.d.) hospital stay was 12.6 days (±13.1). The overall lethality rate of the cohort was 1.5%. The number of inpatients diagnosed with brucellosis decreased exponentially. The group of patients with the highest risk of brucellosis in our study was males under 45 years of age and of urban origin. The lethality rate has reduced to minimum values. It is probable that hospital discharge records could be a good database for the epidemiological analysis of the hospital management of brucellosis and offer a better information collection system than the notifiable diseases system (EDO in Spanish).
Giant NuthatchSitta magnadensity and habitat association in a potential stronghold in northern Thailand
Authors: TECHACHOOCHERT SUPATCHAYA , GALE GEORGE A. , KHUDAMRONGSAWAT JENJIT , SAFOOWONG MONGKOL , ROUND PHILIP D.
Published: May 2021

Populations of the globally endangered Giant NuthatchSitta magnahave declined significantly throughout their small world range in southern China and northern continental South-East Asia. Distance sampling and direct observations were used to estimate the density and habitat use of the Giant Nuthatch in a potential stronghold for the species, Chiang Dao Wildlife Sanctuary, Thailand. Thirteen line transects covering 6.2 km were established in open, pine-oak habitat favoured by the nuthatch, during November 2014 to December 2015. The mean density of Giant Nuthatch was 3.94±1.22 (95% CI = 2.15–7.22) individuals/km2. Hierarchical distance sampling models indicated that habitat use by Giant Nuthatch was strongly correlated with trees of large diameter. A pair of Giant Nuthatches was radio-tracked as they fed nestlings during the 2016 breeding season. The female’s home range, centred on the nest, was 7.79 ha (95% kernel home range), approximately one-fourth of that of the male, 32.01 ha. Giant Nuthatches showed a significant preference for foraging on pinesPinusspp. and used the fissured bark of mature pines in which to store acorns of deciduous tree species. Our research indicates the importance of large, mature trees in open pine-oak forest in supporting Giant Nuthatch populations.
Global E-Commerce Talks at the WTO: Positions on Selected Issues of the United States, European Union, China, and Japan
Authors: Abendin Simon , Duan Pingfang
Published: May 2021

There is a broad consensus that global electronic commerce needs the World Trade Organization (WTO) trade rules to govern it. The current mandate of the WTO is merely to examine the various trade-related aspects of e-commerce. Nevertheless, in recent years, some WTO members have put forward a proposal to begin negotiations for global e-commerce rules which was impeded due to the differing positions of developed and developing members. This paper examines the positions of the United States, the European Union, Japan, and China on the e-commerce multilateral rules negotiation issues. It then takes a look at the prospect of the WTO being able to reach an agreement on e-commerce. The analysis shows that the United States and the European Union have varying views on consumer privacy, information protection, and internet taxation. Although Japan sides with the United States on these issues and China is on the same page as the European Union regarding consumer privacy, China holds a different position from the United States and the European Union on the other two matters. China is not making commitments on data localization, free data flow, and forced transfer of source codes. Therefore, the outlook of the current e-commerce talks is not favorable for concluding WTO e-commerce agreements.
Dragon King in a contentious sea: Sino–Japanese intercultural theatre in 1989
Authors: Stenberg Josh , Björk Tove
Published: May 2021

Interculturalism in theatre, although much critiqued, is an inevitable category for understanding theatre practices and histories. Critical approaches have highlighted the complicity of “hegemonic” Euro-American-led theatre with imperialist structures. Newer critiques tend to focus on encounters in European languages in multicultural cities, and to posit multilateral non-Western collaborations as liberated from colonial power structures. This paper argues that it is necessary to fundamentally rethink interculturalism in theatre by taking seriously the long-standing major theatrical exchanges which do not reference, and are not principally influenced by, Western theatre's sphere. Considering a major example of Sino–Japanese collaboration from 1989,Ryū-Ō(Dragon King), we place it within the genealogy of the two countries’ long-standing theatrical practices of interculturalism. Ryu-O, a kabuki-jingjucollaboration, shows that intra-Asian interculturalism has its own genealogy and is neither new nor beholden to Euro-American models, nor necessarily characterized by the idealism easily invested in overtly counter-hegemonic projects. By examining the show's production process, performance and reception, we re-evaluate how interculturalism in theatre is conceived, urging serious engagement with areas of practice historically grounded and fully independent of both “hegemonic” and “new” intercultural theatre tendencies.
Why Women Earn High Marks: Examining the Role of Partisanship and Gender in Political Evaluations
Authors: Cormack Lindsey , Karl Kristyn L.
Published: May 2021

We present the results of a randomized survey experiment demonstrating that the public evaluates women politicians more highly than men across multiple characteristic assessments. This finding is consistent with a recent wave of research indicating greater preferences for women politicians. Which respondents rate women politicians more highly, and why? We find that women and younger voters do not account for the greater marks given to women politicians. Instead, respondent partisanship and the presumed partisanship of the politician account for a great deal of our findings, with gender playing a complicating role. Democratic and Republican respondents are apt to project their own partisanship onto politicians, and across both parties, we find higher assessments for co-partisan politicians and for women politicians. On the whole, women politicians are evaluated on par with or significantly higher than men politicians across six characteristics, scoring especially well relative to men when politicians are presumed to be members of the opposing party and when traditionally feminine characteristics are assessed.
Representations of Political Leadership Qualities in News Coverage of Australian and Canadian Government Leaders
Authors: Wagner Angelia , Trimble Linda , Curtin Jennifer , Auer Meagan , Woodman V. K. G.
Published: May 2021

How do the media depict the leadership abilities of government leaders, and in what ways are these depictions gendered? Does the focus of leadership evaluations change over time, reflecting the increased presence of women in top leadership roles? To answer these questions, we examined news coverage of 22 subnational government leaders in Australia and Canada, countries in which a significant number of women have achieved the premiership at the state or provincial level since 2007. Analysis demonstrates that newly elected women and men leaders receive approximately the same number of leadership evaluations. Women are assessed based on the same criteria as men. All subnational political leaders are expected to be competent, intelligent, and levelheaded. That journalists prioritize experience and strength while downplaying honesty and compassion indicates a continued emphasis on “masculine” leadership norms in politics. Yet evaluations of new premiers have emphasized the traditionally “feminine” trait of collaboration as key to effective leadership and, over time, have given more attention to likability and emotions when covering male premiers. As our analysis reveals, media conceptualizations of political leadership competencies are slowly expanding in ways that make it easier for women to be seen as effective political leaders.
Seismic Velocity Variations in a 3D Martian Mantle: Implications for the InSight Measurements
Authors: Plesa A.‐C. , Bozdağ E. , Rivoldini A. , Knapmeyer M. , McLennan S. M. , Padovan S. , Tosi N. , Breuer D. , Peter D. , Stähler S. , Wieczorek M. A. , van Driel M. , Khan A. , Spohn T.
Published: May 2021

We use a large data set of 3D thermal evolution models to predict the distribution of present‐day seismic velocities in the Martian interior. Our models show a difference between maximum and minimum S wave velocity of up to 10% either below the crust, where thermal variations are largest, or at the depth of the olivine to wadsleyite phase transition, located at around 1,000–1,200 km depth. Models with thick lithospheres on average have weak low‐velocity zones that extend deeper than 400 km and seismic velocity variations in the uppermost 400–600 km that closely follow the crustal thickness pattern. For these cases, the crust contains more than half of the total amount of heat‐producing elements. Models with limited crustal heat production have thinner lithospheres and shallower but prominent low‐velocity zones that are incompatible with Interior exploration using Seismic Investigations, Geodesy and Heat Transport (InSight) observations. Seismic events suggested to originate in Cerberus Fossae indicate the absence of S wave shadow zones in 25°–30° epicentral distance. This result is compatible with previous best fit models that require a large average lithospheric thickness and a crust containing more than half of the bulk amount of heat‐producing elements to be compatible with geological and geophysical constraints. Ongoing and future InSight measurements that will determine the existence of a weak low‐velocity zone will directly bear on the crustal heat production.