bluuebunny/crossref_metadata_2025 huggingface dataset:
Acute Kidney Injury in Patients With Acute Chemical Poisoning: the Experience of the Toxicological Center in Ryazan
Authors: Shatrova N. V. , Rudakova M. N. , Zaytseva L. G. , Varenova Zh. A.
Published: January 2021

Relevance. Acute kidney injury (AKI) is one of the leading causes of death worldwide. However, the epidemiology of AKI is not well understood. In Russia, toxic kidney damage plays a significant role in the nosological structure of AKI — 12.2%.

Aim of study. To study the features of AKI in patients with acute chemical poisoning.

Material and methods. We analyzed 26 case histories of patients with acute chemical poisoning with AKI (according to KDIGO). The comparison group included 25 patients with acute chemical poisoning without AKI. All patients were hospitalized in a toxicological center on the basis of the emergency department of the Ryazan Region State Budgetary Institution “City Clinical Emergency Hospital” (SBI RR “CCH EMC”) in 2016–2018. The analysis of the annual reports of the chief toxicologist of the Ministry of Health of the Ryazan Region for 2016–2018 was carried out. Data processing was performed using Microsoft Office Excel 2013 and on the website medstatistic.ru (Pearson’s chi-square test and Fisher’s exact test).

Results. In most patients AKI developed during poisoning with cauterizing action substances - 38.4% (23% - vinegar essence, 15.4% - unidentified cauterizing action substance). The poisoning with alcohol substitutes (12%) took the 2nd place, with narcotic substances (8%) – the 3 rd place. Also, isolated cases of AKI (4% each) were reported in case of poisoning with pregabalin, tramadol, ketorol and ethanol. Poisoning with an unknown toxicant was noted in 29.6% of cases. Most patients (69.2%.) had stage 3 AKI. The second stage was registered in 7.7% of patients, the first — in 23.1%. Proteinuria was detected in all patients who underwent common urine test (CUT). Infusion therapy using crystalloids was performed in 100% of cases.

Conclusion. Acute renal injury most often develops in acute poisoning with cauterizing poisons. The development of acute kidney injury in acute chemical poisoning leads to an increased risk of death. Acute kidney injury is the second most common immediate cause of death in acute chemical poisoning. Infusion therapy is an integral part of the management of toxicological patients with acute kidney injury.
Acute Hemolytic Reaction After Transfusion of Erythrocyte-containing Blood Components: Causes, Prevention, Clinical Cases
Authors: Andreyeva Ya. S. , Mayorova O. A. , Bulanov A. Yu. , Momotyuk K. S. , Zinkin V. Yu. , Belyakova V. V. , Vatagina E. A.
Published: January 2021

The article concerns the problem of studying the causes of the development of hemolytic reactions after transfusion of erythrocyte-containing blood components. The ways of preventing hemolysis as a result of blood transfusions are considered. Clinical cases are described.
Photochemical Dermatitis Due to Contact With Sosnovsky Hogweed
Authors: Simonova A. Yu. , Belova M. V. , Ilyashenko K. K. , Pidchenko N. E. , Potskhveriya M. M. , Sachkov A. V. , Ponomarev I. N.
Published: January 2021

Introduction. Today, the spread of the Sosnovsky hogweed plant has acquired an unprecedented scale, which is accompanied by an annual increase in the number of victims due to the occurrence of photochemical dermatitis (PD).

Aim of study. To study the clinical picture of PD arising in patients as a result of contact with Sosnovsky hogweed juice, to develop measures for their prevention and treatment.

Material and methods. The study involved 139 patients with a diagnosis of photochemical dermatitis who were treated in the department of acute poisoning and somatopsychiatric disorders of the N.V. Sklifosovsky Research Institute for Emergency Medicine.

Results. All patients had skin lesions of varying prevalence, more often the upper and lower extremities, similar in depth to superficial thermal burns of I, II, IIIA degrees.

Conclusions. The complex of treatment for patients should include detoxification, antihistamine, analgesic, hormonal, antibacterial therapy, as well as local treatment carried out by combustiologists.
Small Intestine Artery False Aneurysm Embolization
Authors: Prozorov S. A.
Published: January 2021

Bleeding from an aneurysm of a small intestine artery is a formidable complication, the treatment remains a difficult problem. In this case, aneurysm embolization is indicated. The aim of the article is to describe the role of embolization in the treatment of bleeding in an elderly patient, to analyze the efficacy and risk. The advantage of the intervention is minimal invasiveness and low blood loss. The presented observation showed the effectiveness of endovascular embolization in the rupture of a pseudo-aneurysm.
Negotiative Hermeneutics of Khaled Abou El Fadl: Truth Postponement and Negotiating The Meaning of Text in Speaking In God's Name
Authors: Syaddad Irza Anwar
Published: January 2021

This study aims to map the ontological and epistemological aspects of Negotiative Hermeneutics through a philosophical approach. Negotiative Hermeneutics is a new hermeneutic model initiated by Khaled Abou El Fadl to criticize gender-biased and misogyny fatwas issued by Al-Lajnah ad-Dā`imah li al-Buhūts al-'Ilmiyyah wa al-Iftā`, or the Fatwa Committee Saudi Arabia. Prioritizing texts understanding through a psychological, social context, and other perspective makes this model different from other hermeneutics. Negotiative Hermeneutics more focuses on the negotiation process for sustainable in the three pillars of hermeneutics: author, text, and reader. This iterative process on linguistic, cultural, etc. This study analyzed the weaknesses of the Negotiative Hermeneutics negotiation movement based on the misogyny fatwa case of the Saudi Arabian Fatwa Committee using the critical discourse analysis method. The results indicated that the text is ontologically sacred and authoritative; authorship of the Quran and the Prophet Sunnah stopped at the first author. The epistemological viewed meaning is obtained from endless negotiations among the three pillars of hermeneutics. The weakness is Khaled's disregard for the fact that the ulama's fatwa depends on royal authority. Last, the significance of this paper, especially regarding the shortcomings in Khaled's theory, is to present evidence that a fatwa produced by the ulama's ijtihad is not autonomous at all, even from the ulama itself, because it is also the result of a bargaining chip between ulama and the royal authority
The Understanding of Hadith “Ballighû ‘annî walau Âyah" in Twitter
Authors: A'yun Qurrata , Hananta Yor
Published: January 2021

So far, in social media, the hadith "ballighū 'annī walau āyah" has been widely misunderstood as a proposition for preaching even if it is only one verse. On the other hand, this hadith is also used as a suggestion for preaching without understanding the full meaning of a verse. This understanding is different from the real understanding, so a comprehensive discussion is needed to describe it. This article aims to identify misconceptions in understanding the hadith "ballighū 'annī walau āyah" on social media twitter and meet them with the correct meanings of the hadith. This study is a qualitative study which classify and analyze data by descriptive analysis. The discussion of this article explains how the hadith ballighū 'annī walau āyah is understood by Twitter netizens. The understanding of netizens is grouped into two categories, namely those that are appropriate and not in accordance with their real understanding. The factors that lead to misunderstanding of the hadith ballighū 'annī walau āyah are the insights of the hadith that are conveyed only a piece (not intact) and the dissemination of understanding through social media twitter with a short number of characters. This phenomenon causes a transformation of the hadith understanding in the form of degradation and distortion
Kellő védelmet biztosít-e az Ebktv. a munkaerőpiacon a gyermekvállaláshoz?
Authors: Földvári Zoltán
Published: January 2021

Az elmúlt években számos állami intézkedés célozta a születésszám nevelését Magyarországon, elsősorban a szülők közvetlen pénzügyi támogatása révén. A gyermeknevelés iránti kötelezettségvállalás azonban nem csak anyagi kérdés, a munka és a magánélet egyensúlya ugyanolyan fontos a szülők, és különösen a nők számára. Célom alapvetően az egyenlő bánásmód joganyagának vizsgálata abból a szempontból, hogy várandós nők és a kisgyermekes szülők megkülönböztetését a foglalkoztatás során mennyiben tudja megakadályozni és szankcionálni. Egy rövid problémafelvetést követően bemutatom a téma uniós jogi fejlődését és hazai jogszabályi hátterét, különös tekintettel az eljárási kérdésekre, majd pedig az Egyenlő Bánásmód Hatóság esetjogán keresztül kívánom elemezni az egyes, egyenlő bánásmód követelményét sértő magatartások megjelenését a gyermekvállalással összefüggésben. Arra a problémára keresem a választ, hogy egyrészt megvannak-e azok a jogszabályi keretek, amelyek ahhoz szükségesek, hogy a gyermekvállalást tervező nők és családok ne legyenek kiszolgáltatottak a munkáltatóknak, másrészt mennyiben érvényesülnek ezek a keretek a gyakorlatban, harmadrészt pedig található-e valamilyen fejlesztendő terület az egyenlő bánásmód szabályozásának terén.
Közigazgatási szervezési elvek érvényesülése a közoktatási igazgatásban
Authors: László Vilmos Csongor
Published: January 2021

1990 után az állami oktatási intézményeket a helyi önkormányzatok tartották fenn és ellenőrizték. Ez az időszak a decentralizáció korszaka volt, melynek előnyeit és hátrányait vizsgálom a tanulmányban. 2011 után volt egyfajta jogalkotási decentralizáció, amely után az oktatásnak működési szerepe volt vagy lehetett volna, de az állami felelősséggé vált. Az állam mint volt ágazati koordinátor, ezt követően a közhatalmi hatósága mellett fenntartói szerepet vállalt.
Az adminisztráció két alrendszerének két alapvető változása történt 1990-es megalakulása óta, de főleg 2010 után. Ezek részben strukturális jellegűek voltak, több lépcsőben érintették az államszervezetet, majd a központi integrációt és az önkormányzatok újraszabályozásához kapcsolódó változásokat, tükrözve az állam szerepének módosulását, a Neoweber állameszmék kibővülését és a modernizációt.
Ezen tényezők egy részét nemzetközi hatások generálták, de a magyar alapelvek is szerepet játszottak. Ez a tanulmány azt elemzi, hogy a részleges feltételek hogyan tükröződnek az oktatásigazgatásban, hogyan követték az igazgatási ágak az általános tendenciákat. Azt is megvizsgálom, hogy mennyire volt sikeres ezeket a szerepeket együtt kezelni és bizonyos pontokon szétválasztani.
EIN LOGOS FÜR DAS SEIN UND DEN GOTT. HEIDEGGERS AUSEINANDERSETZUNG MIT DER THEOLOGIE AB DEN DREISSIGER JAHREN II
Authors: MARAFIOTI Rosa Maria
Published: January 2021

A Logos for Being and God. Heidegger’s Confrontation with Theology from the 1930s. II. Heidegger’s entire itinerary is characterised by the search for a living relationship with God, and thus for a Logos able to think and name the divine without objectifying its divinity. Getting into a dialogue with Western philosophers and theologians and distinguishing the fields of thinking, faith and science one from the other, since the 1930’s Heidegger claims that, if the traditional theology has seen God as the supreme being, metaphysics, on its part, has identified it with Being as such. According to Heidegger, the onto-theo-logical constitution of metaphysics has developed itself by means of the reception of the Jewish-Christian concept of an almighty God as creator. This process has led to the fulfilment of the machination in the totalitarian regimes of the 20th century. Heidegger speaks about the poverty of thought and about the consequent impossibility of building an ontology as well as a theology. Nevertheless, he still waits for the hint of a last God, in so far as he assumes that a renewed manifestation of the divine must be prepared through the overcoming of the forgetfulness of Being and God.
POURQUOI DEVONS-NOUS ABANDONNER - AVEC PRUDENCE - LE CONCEPT CARTESIEN D’ÂME ?
Authors: SARFATI Jean-Jacques
Published: January 2021

Why Should We Abandon - With Caution - the Cartesian Concept of Soul? In this text, the author proposes to show that we must abandon the Cartesian approach to the soul while remaining cautious. He recalls the context in which this thesis was defended. This thesis is based on an interpretation of Genesis that condemns knowledge. It shows how this interpretation is wrong.
Deposition time and annealing effects on morphological and optical properties of ZnS thin films prepared by chemical bath deposition
Authors: Chabou N. , Birouk B. , Aida M.S. , Raskin J.P.
Published: January 2021

Nanocrystalline zinc sulfide (ZnS) thin films are prepared on glass substrates by chemical bath deposition (CBD) method using aqueous solutions of zinc chloride, thiourea ammonium hydroxide along with non-toxic complexing agent tri-sodium citrate in alkaline medium at 80 °C. The deposition time and annealing effects on the optical and morphological properties are studied. The morphological, compositional, and optical properties of the films are investigated by scanning electron microscopy (SEM), X-ray energy dispersive spectroscopy (EDAX) and UV-Vis spectroscopy. SEM micrographs exhibit uniform surface coverage. UV-Vis (300 nm to 800 nm) spectrophotometric measurements show transparency of the films (transmittance ranging from 69 % to 81 %), with a direct allowed energy band gap in the range of 3.87 eV to 4.03 eV. After thermal annealing at 500 °C for 120 min, the transmittance increases up to 87 %.
Influence of nitrogen configuration on the electrochemical properties of carbonized poly(acrylonitrile)-ionic liquid as anode materials in lithium ion batteries
Authors: Wang Lei , Meng Yanshuang , Du Mengqi , Wang Gongrui , Xia Jun , Zhu Fuliang , Zhang Yue
Published: January 2021

A sequence of N-doped carbon materials has been synthesized using poly(acrylonitrile)-ionic liquid copolymers as carbon precursors. The nitrogen content and configuration in carbon materials has been changed regularly within a certain range by adjusting the proportion of ionic liquids. We found that the capacity and rate performance increased dramatically after the introduction of ionic liquids, which was attributed to incorporation of higher amount pyridinic-N, pyrrolic-N into the carbon materials. Besides, with the increase of the graphitic-N, the initial Coulombic efficiency decreased from 58.5 % to 53.47 % and the RSEI raised from 66.34 Ω to 140.96 Ω, which was attributed to the higher cohesive energy of Li dimmer than adsorption energy of graphitic-N with Li, since more lithium clusters during the formation of SEI film were formed. The electrochemical tests also revealed the negative role of graphitic-N in the capacity. Therefore, this work provides a feasible method to design the nitrogen content and configuration of the N-doped carbon materials.
Effect of coating steps on uniformity and gas permeability of mesoporous layers in ceramic membranes
Authors: Pakdehi Shahram G. , Rahimi Elham , Shafiei Korosh
Published: January 2021

Porous silica, silica-cobalt, silica-zirconia and zirconia membranes were synthesized by the sol-gel method. Multi-step coating (two, six, and ten steps) was used to reduce the defectiveness of the mesoporous layer. Scanning electron microscopy (SEM) images indicated that an increase in the number of coating steps improved the mesoporous layer quality. The results obtained from gas permeability tests with nitrogen and argon, however, indicated a reduction in the gas permeability with increasing coating steps. The reduction in gas permeability from two to six coating steps was more pronounced than from sixto ten- coating steps. It was found that six-step coating was economically justified in obtaining a uniform mesoporous layer. The results of pore radius calculations by Knudsen flow mechanism revealed that the pores in the silica, silica-cobalt, and zirconia membranes were in the mesoporous range. The sols with a mean particle size more than 100 nm are not recommended for synthesis of mesoporous layer free of defects. Furthermore, the type of acid used as a catalyst is also important in obtaining a layer without defectiveness.
Implementation of the Six Sigma Methodology in Increasing the Capability of Processes in the Company of the Furniture Industry of the Slovak Republic
Authors: Simanova Ľubica , Gejdoš Pavol
Published: January 2021

The aim of the article is to present the results of a case study focused on the implementation of the Six Sigma methodology in order to improve the quality and increase the efficiency of furniture production processes. Positive results of implementation after the implementation of corrective measures were achieved in the values of process capability coefficients, reduction of nonconformities and subsequent reduction of DPMO, increase of the values of the level of efficiency and sigma of the critical process.In the processing of the results, classical methods of research work were used such as analysis, synthesis, comparison, descriptive statistics, coefficients Cp a Cpk, DPMO, level of efficienty and sigma, and also graphic methods.
Age and Depositional Environment of Walat Formation Based on Palynological Analysis in Sukabumi Regency, West Java, Indonesia
Authors: Rachman Rizki Satria , Winantris  , Muljana Budi
Published: January 2021

Walat Formation is equivalent to Bayah Formation. This formation is the beginning of Bogor basin deposition. In this case, age and environment of this formation have been analyzed by previous researchers, but the results of age and environment interpretations have different ranges, especially from its palynological aspect which until now Walat Formation is rarely analyzed using this aspect. This research was conducted to identify the age and depositional environment of Walat Formation in Sukabumi region by using pollen and spores to confirm different interpretations of previous studies. Measure section was carried out in sampling and chemical treatment method was carried out to see palynomorph content in the rock. Furthermore, data analysis was carried out with range of interval zones and pollen grouping based on their environment.

The results show that Walat Formation has Late Eocene age based on the interval zone between first occurrence of Verrucatosporites usmensis and Meyeripollis naharkotensis, and the last occurence of Proxapertites operculatus, Proxapertites cursus, and Cicatricosisporites eocenicus. Walat Formation has fluvial depositional environment characterized by the dominance of Proxapertites operculatus and Proxapertites cursus. The results of this study confirm that the Walat Formation has an Eocene age and a fluvial depositional environment from a palinological aspect.
Estimation of The Structural Pattern and Sedimentary Thickness Over Part Of Anambra Basin, Nigeria Using Aeromagnetic Data
Authors: Ikioda Priscilla E. , Ofoegbu Charles O. , Uko Etim D. , Ayanninuola Olatunji S.
Published: January 2021

Aeromagnetic data acquired over part of the Anambra Basin is analyzed to determine the structural pattern and sedimentary thickness of the basin. The study area is covered by high resolution aeromagnetic data on sheets 301 (Udi), 302 (Nkalagu), 312 (Okigwe) and 313 (Afikpo), and lies between latitudes 5o30’0’‘-6o30’0’‘ and longitudes 7o0’0”-8o0’0”. The whole area was divided into 25 overlapping blocks of 37.2km2 each and a 2D energy spectral analysis was carried out. Total magnetic intensity data was subjected to filtering and analytical techniques to determine the structural pattern, mineralization potential, depth to the basement, variation in the sedimentary thickness. The structural map generated using the vertical derivatives shows that the major structural orientation of the area is in the ENE-WSW trend and the minor trend is the NW to SE direction widespread all over the area. These structures are as a result of the various near-surface magnetic intrusion within the study area. The spectral analysis result shows two depth layers, the deep and the shallow depth, the depth to magnetic basement for the deep anomalous source ranges from 3.3km to 4.8 4km with an average depth of 3.99km, while the depth to shallow magnetic sources ranges between 0.46km to 0.67km and an average of 0.56km within the area. The mineralization pattern in this area follows the ENE-WSW direction.
Akceptacja choroby i jej związek z jakością życia pacjentów z łuszczycą
Authors: Zielińska-Więczkowska Halina , Pietrzak Natalia
Published: January 2021

Introduction. Psoriasis, as a condition easily noticeable by the immediate environment, causes embarrassment and psychological problems, and lowers the quality of life in the sufferers. Aim. The study aimed at determining the level of acceptance of illness and quality of life as well as their correlations in the light of sociodemographic factors. Material and methods. The study involved 120 patients with psoriasis, but statistical analysis eventually included 101 patients aged over 18 (59 women and 42 men). The study was based on a literature review and a diagnostic survey using both standardized tools, including the Acceptance of Illness Scale (AIS) and the WHOQOL-Bref quality of life assessment questionnaire, as well as a questionnaire of own design addressing possible limitations on the everyday functioning of individuals with psoriasis. Results. The mean score for acceptance of illness was 30.37 points. Lower results in the AIS scale were obtained by women. Mean scores pertaining to individual domains of quality of life were as follows: physical 64.02, psychological 57.28, social relations 64.56, and environmental 63.10. Educational attainment of the participants correlated significantly with quality of life in the environmental (r = 0.333; p = 0.001) and psychological (r = 0.254; p = 0.012) domains. The level of acceptance of illness correlated with the psychological (r = 0.356; p = 0.000), physical (r = 0.326; p = 0.001) and environmental (r = 0.212; p = 0.033) domains. Conclusions. Patients with psoriasis demonstrated a high level of acceptance of illness, which affected their functioning mostly in the psychological and physical domain. Continuous development of an individual contributes to their better functioning in the environment and in the psychological domain.
Rancang Bangun Alat Tanam Benih Kangkung Darat (Ipomoea Raptana Poir)
Authors: Nasichin Nasichin , Fajarsukoco Fajarsukoco , Satria Duta , Sebastian Yose , Yulia Meinilwita
Published: January 2021

Kale spinach is a type of vegetable that is widely consumed by people in Indonesia. It’s contains protein, carbohydrates, calcium, iron, sodium, phosphorus, fiber, vitamins A and C. The kale spinach is a low-calorie vegetable. The purpose of this research is to design kale spinach seed planting tool with a semi-mechanical system which power comes from human power, this tool is operated by pulling a lever on the tool so that the tool can work. After the manufacture of kale seed planting is complete, the authors test the performance of the tool capacity, and from the results of the performance test of this tool it can be concluded that it can work well. The results of the performance test of the capacity of this tool to plant water spinach seeds with an area of 0.0005 ha takes 0.007 hours with an average speed of 0.2 m/s, the average seeds that fall per hole are 3 seeds, 98.6% efficiency, The theoretical capacity is 0.072 ha/hour, the effective capacity is 0.071 ha/hour, the percentage of growth is 95%, the average distance between plants is 10 cm, and the average distance between rows of plants is 10 cm.
O papel do 10-MDP no processo da adesão
Authors: Lima Amanda da Silva , Rúbio Gabriel Ramos , Rodrigues Lorena dos Santos , Finck Nathalia Silveira
Published: January 2021

Esse artigo buscou analisar a atuação dos monômeros funcionais no processo da adesão. A introdução destes nos sistemas adesivos permitiu intensificar as forças adesivas através de ligações químicas e, dessa forma, aumentar a qualidade da odontologia restauradora. O 10-metacriloiloxidecil di-hidrogênio fosfato (10-MDP) é um monômero que possui a capacidade de melhorar a adesão quando comparado aos outros monômeros funcionais. Dessa forma, o objetivo deste artigo é apresentar, por meio de uma revisão de literatura, o papel do monômero 10-MDP no processo de adesão em restaurações dentárias. Foi realizado um levantamento bibliográfico nas bases de dados Medline, BVS e Lilacs utilizando como termos de busca: Falha de Restauração Dentária; Cimentos Dentários; Odontologia; Adesivos. A literatura enfatiza que o 10-MDP é um monômero que se destaca por apresentar ligação tanto a hidroxiapatita dos tecidos dentais quanto aos compósitos e cimentos resinosos promovendo, assim, uma união mais estável e duradoura. Além disso, também atua como agente ligante entre compósitos resinosos e óxidos metálicos, melhorando a resistência de união à zircônia, por exemplo, através de uma interação química entre sua superfície e o cimento resinoso aplicado. Sendo assim, o 10-MDP é considerado como padrão ouro para adesão em dentina.
Hydrogen peroxide: history of discovery, chemical and biochemical aspects, place of formation and role in the body (review)
Authors: Еникеев Д.А. , Кузнецов К.О. , Еникеев О.А. , Кузнецова Д.Р. , Хисамов Э.Н. , Юрасов А.Ю. , Фаюршин А.З. , Садыков А.Р. , Закиев А.М.
Published: January 2021

В статье приведен обзор литературы за последние 100 лет. Затронута история открытия и применения перекиси водорода в различные годы. Подробно описаны химические и физические свойства перекиси водорода, её механизмы действия in vivo и in vitro. Затронута тема образования перекиси водорода в собственных клетках организма человека и животных, описаны физиологические функции эндогенной перекиси водорода в человеческом теле.

The article provides a review of literature for the past 100 years; touches on the history of discovery and the use of hydrogen peroxide in different years; describes in detail chemical and physical properties of hydrogen peroxide, and its mechanisms of action in vivo and in vitro. The review addresses the formation of hydrogen peroxide in human and animal cells and describes physiological functions of endogenous hydrogen peroxide in the human body.
General pathology in D.S. Sarkisov scientific creativity
Authors: Пальцын А.А.
Published: January 2021

Пушкин писал: «Гордиться славою своих предков не только можно, но и должно, не уважать оной есть постыдное малодушие». Ещё больше оснований и святее чувство гордости к достойным её современникам. Во-первых, потому, что мы их лучше знаем (отсутствует ореол «легенды»), тем более, если знаем через личное знакомство, совместную работу (что дорогого! стоит), участие в житейских радостях и горестях друг друга. Отсутствие «предковости» очищает наше чувство, устраняет из него эгоистические мотивы. Донат Семенович был сыном академика и Главного ученого секретаря АМН СССР. Но в его жизни, карьере невозможно найти ни одного назначения или награды, полученных раньше времени или не заслуженных собственным трудом и талантом. В профессии он выделялся трудовой одержимостью, бескомпромиссной борьбой за научную истину, популярностью среди клиницистов, высоким, ярким и удивительно гармоничным сочетанием в одном человеке прозектора и общего патолога. В этом отношении к нему близки только Р. Вирхов и И.В. Давыдовский. Но он единственный человек в мире - автор закона философии!

Pushkin wrote: “To be proud of the glory of one’s ancestors is not only possible, but also required, for not to respect is a shameful cowardice.” Even more justified and holier is the sense of pride for prideworthy contemporaries. First, because we know them better (without a halo of “legend”), especially when we know them through personal acquaintance, cooperative work (which stands high), participation in each other’s everyday joys and sorrows. The absence of “ancestry” purifies our feeling, removes egoistic motives from it. Donat Semenovich was the son of an Academician and the Chief Scientific Secretary of the USSR Academy of Medical Sciences. Nevertheless, in his life and career, it is impossible to find any appointments or awards received ahead of time or not deserved by his own work and talent. Professionally, he stood out for an uncompromising struggle for scientific truth and a phenomenally high, bright representation in one person of a dissector and a general pathologist. In this respect, only R. Virkhov and I.V. Davydovsky are close to him. But he is the only person in the world as the author of the law of philosophy!
Using Atomic Charges to Describe the pKa of Carboxylic Acids
Authors: Haslak Zeynep Pinar , Zareb Sabrina , Dogan Ilknur , Aviyente Viktorya , Monard Gerald
Published: January 2021

In this study, we present an accurate protocol for the fast prediction of pKa's of carboxylic acids based on the linear relationship between computed atomic charges of the anionic form of the carboxylate fragment and their experimental pKa values. Five charge descriptors, three charge models, three solvent models, gas phase calculations and several DFT methods (combination of eight DFT functionals and fifteen basis sets) were tested. Among those, the best combination to reproduce experimental pKa's is to compute NPA atomic charge using the SMD model at the M06L/6-311G(d,p) level of theory and selecting the maximum atomic charge on carboxylic oxygen atoms (R^2 = 0.955). The applicability of the suggested protocol and its stability along geometrical changes are verified by molecular dynamics simulations performed for a set of aspartate, glutamate and alanine peptides. By reporting the calculated atomic charge of the carboxylate form into the linear relationship derived in this work, it will be possible to estimate accurately the amino acid’s pKa's in protein environment.
Testing the Limitations of MD-based Local Electric Fields Using the Vibrational Stark Effect in Solution: Penicillin G as a Test Case
Authors: Kozuch Jacek , Schneider Samuel , Zheng Chu , Ji Zhe , Bradshaw Richard T , Boxer Steven
Published: January 2021

Non-covalent interactions underlie nearly all molecular processes in the condensed phase from solvation tocatalysis. Their quantification within a physically consistent framework remains challenging. Experimental vibrational Stark effect (VSE)-based solvatochromism can be combined with molecular dynamics (MD) simulations to quantify the electrostatic forces in solute-solvent interactions for small rigid molecules and, by extension, when these solutes bind in enzyme active sites. While generalizing this approach towards more complex (bio)molecules, such as the conformationally flexible and charged penicillin G (PenG), we were surprised to observe inconsistencies in MD-based electric fields. Combining synthesis, VSE spectroscopy, and computational methods, we provide an intimate view on the origins of these discrepancies. We observe that the electrics fields are correlated to conformation-dependent effects of the flexible PenG side-chain, including both local solvation structure and solute conformational sampling in MD. Additionally, we identified that MD-based electric fields are consistently overestimated in 3-point water models in the vicinity of charged groups; this cannot be entirely ameliorated using polarizable force fields (AMOEBA) or advanced water models. This work demonstrates the value of the VSE as a direct method for experiment-guided refinements of MD force fields and establishes a general reductionist approach to calibrating vibrational probes for complex (bio)molecules.
Financial strategic impact on clinical laboratory managers - A review
Authors: Sai Sudha Mahajan  , Pratibha Ramani
Published: January 2021

The cost of operating a clinical lab where cost containment remains a major challenge is to be maintained in conjunction with smooth running of laboratory operations. This study aimed to account the results of service cost using workload-based costing in clinical laboratories. The review aimed at establishing cost containment strategies of all lab test services based on workload of the technical team in a clinical lab. Articles were searched in online databases, such as PUBMED, MEDLINE and Google scholar using keywords “financial, strategic, impact, clinical laboratory, managers.” Manual Search of Journals were also done. Articles were reviewed and analysed. The relevant articles were reviewed which showed the value analysis of lab services and its costs along with technical staff workload provides insights on the relationship between variables and the uncertainty of financial strategic effects.
MODERN DIRECTIONS IN THE ECONOMIC GROWTH OF THE TVER REGION
Authors: Толкаченко Оксана Юрьевна
Published: January 2021

Цель статьи заключается в предложении автором основных векторов экономического роста региона на основании проведенного анализа состояния и уровня развития промышленности, демографической ситуации и объемов привлеченных инвестиций. Сформулированы ключевые направления наращивания экономического потенциала области в сложившихся современных условиях. К возможным поступательным направлениям развития автор относит: развитие туристко-рекреационной сферы; динамичное движение сельского хозяйства региона посредством реализации комплекса мероприятий поддержки со стороны профильного министерства Тверской области; прирост объемов продукции, производимой предприятиями промышленности; выстраивание позитивного инвестиционного климата и активизация инвестиционной деятельности путем ориентации на инновационную деятельность. Научная новизна полученных результатов заключается в формировании индивидуальной траектории развития экономического потенциала Тверской области, основанной на анализе текущего состояния элементов хозяйственной системы региона и на практике применения эффективных инструментов обеспечения экономического роста на территориях других регионов Российской Федерации.

The purpose of the article is to propose the main vectors of economic growth of the region based on the analysis of the state and level of industrial development, the demographic situation and the volume of attracted investments. Key directions for increasing the economic potential of the region in the current conditions are formulated. The author refers to possible progressive areas of development: the development of the tourist and recreational sphere; dynamic movement of the region's agriculture through the implementation of a set of support measures by the relevant ministry of the Tver region; Increase in industrial output; Building a positive investment climate and enhancing investment by focusing on innovation. The scientific novelty of the results obtained consists in the formation of an individual trajectory for the development of the economic potential of the Tver region, based on an analysis of the current state of elements of the economic system of the region and the practical application of effective tools for ensuring economic growth in the territories of other regions of the Russian Federation.
O PROTAGONISMO DE ESTUDANTES DO ENSINO MÉDIO PARA UMA EDUCAÇÃO SEXUAL EFICIENTE E APRAZÍVEL
Authors: Santos Iana Marassi dos , Hardoim Edna Lopes , Ferreira Katiane Mara
Published: January 2021

A Educação Sexual, quando oferecida em nossas escolas, responde às necessidades de aprendizagem dos estudantes do século XXI? Esta questão motriz originou se de momentos de discussão com estudantes da rede pública de ensino. O objetivo geral desta pesquisa propõe o desenvolvimento de uma Educação Sexual inovadora, ancorada em elementos dos métodos da aprendizagem ativa, tendo o aluno no papel de protagonista do seu processo educacional. Este estudo foi organizado em seis momentos e desenvolveu-se em uma escola pública na cidade de Várzea Grande – MT, com estudantes do 2º ano do Ensino Médio. A pesquisa caracterizou-se como qualitativa com abordagem investigativa, fundamentada na ABProj - Aprendizagem Baseada em Projetos, alicerçada na aprendizagem colaborativa e no uso das Tecnologias Digitais de Informação e Comunicação. Iniciamos com a problematização, empregando a roda de conversa seguida da construção das hipóteses pelos estudantes com a aplicação da técnica de tempestade de ideias (brainstorming), para as chamadas “reuniões de foco investigativo”, com o propósito de investigar possíveis resoluções às questões levantadas pelos estudantes e futuro compartilhamento com outros jovens. A coleta de dados se deu por meio da aplicação de questionários e observações in loco. Com o presente trabalho, observamos que a abordagem investigativa associada aos métodos ativos despertou o interesse, a criatividade e o compartilhamento de saberes com outros colegas, bem como potencializou o uso de suas habilidades, o que nesta pesquisa resultou na produção autoral de páginas no Instagram e na criação do aplicativo educacional Educasex.
FEIRA DE CIÊNCIAS DO ESTADO DE ALAGOAS: CONQUISTAS E DESAFIOS NO DESENVOLVIMENTO DOS TRABALHOS
Authors: Santos Bibiane de Fátima , Mota Maria Danielle Araújo , Barguil Paulo Meireles
Published: January 2021

Nas últimas décadas, inúmeros trabalhos relatam a contribuição das Feiras de Ciências e dos Museus de Ciências na divulgação científica, elencando possibilidades, conquistas e desafios. Embora diversos autores relatem a importância das Feiras de Ciências na divulgação do conhecimento científico, no ambiente escolar e na sociedade, é necessário admitir que elas possuem limitações na realização e/ou na exposição dos trabalhos. Essa pesquisa teve como objetivo analisar como foram desenvolvidos os trabalhos apresentados na Feira de Ciências do Estado de Alagoas (FECEAL) em 2019, pois conhecer as escolhas, os desafios e as conquistas que os estudantes vivenciam na realização dos trabalhos pode contribuir para ampliar as aprendizagens dos participantes – estudantes e visitantes – das Feiras de Ciências. Foi realizada uma pesquisa qualitativa, mediante questionário, com 41 (quarenta e um) estudantes de escolas públicas do estado de Alagoas, que apresentaram trabalho na FECEAL 2019. O questionário continha 7 (sete) perguntas sobre: o tipo de trabalho, o motivo da participação, o processo de escolha do tema, o local, a metodologia, o alcance dos objetivos e o tipo de auxílio recebido. Os dados colhidos ratificam que a Feira de Ciência pode favorecer a produção e divulgação científica, melhorando a aprendizagem discente, bem como o vínculo entre escola e sociedade. Identificamos limites no desenvolvimento dos trabalhos apresentados na FECEAL 2019, de modo especial, no tipo de trabalho e na metodologia. Para enfrentar esses desafios, é necessário o apoio dos órgãos competentes para melhorar as condições de trabalho docente, a formação continuada e a infraestrutura.
Hacia una perspectiva glotopolítica y etnográfica de las literacidades
Authors: Castiblanco Prieto Andrey Sebastián , Rudas-Burgos Daniel
Published: January 2021

Basándose en estudios antropológicos acerca de la lectura y la escritura, este artículo parte de la identificación de un dualismo entre dos perspectivas: la universalista y la relativista. A partir de dos etnografías, una en un club de lectura en un municipio cercano a Bogotá y otra en un programa de alfabetización dirigido a adultos mayores de un barrio periférico de Bogotá, los investigadores identifican en ambos contextos que ambos polos del dualismo se solapan en la práctica. Posteriormente, el artículo problematiza la visión dualista y recomienda una aproximación glotopolítica y etnográfica para abordar la enseñanza de lectura y escritura.
Elaboración del duelo en familiares de las víctimas de desaparición forzada en el departamento del Caquetá
Authors: Romero Sáenz Laura Camila , Gómez Valencia Jhon Sebastián
Published: January 2021

El presente artículo tiene como objetivo comprender la elaboración del duelo en los familiares de las víctimas de desaparición forzada en el Caquetá. Se realizó mediante un enfoque cualitativo de investigación a través del diseño histórico-hermenéutico, en el que se utilizó la entrevista semiestructurada como método de recolección de información. Como resultado se evidenció que la elaboración del duelo se extiende en el tiempo debido al mantenimiento de la esperanza vinculada al regreso de su ser querido con vida, la importancia simbólica del cuerpo para practicar los ritos fúnebres y la necesidad de conocer la verdad en torno a los hechos de la desaparición. A modo de conclusión, se evidencia que contar las historias constituye un elemento sanador y permite conocer las particularidades frente a la elaboración del duelo.
EXOGENIC AND ENDOGENIC FACTORS OF THE DEVELOPMENT OF THE AGRARIAN SPHERE OF THE ECONOMY OF THE REPUBLIC OF SOUTH OSSETIA
Authors: Semin Aleksandr , Mazloev Vitaliy , Kibirov Alihan
Published: January 2021

The study is devoted to the development of the agrarian sphere of unrecognized (partially recognized) small states, on the example of the Republic of South Ossetia. The purpose of this work is to identify exogenous and endogenous factors affecting the increase in the efficiency of agricultural production within the framework of the export-oriented model of the national economy of the RSO. Research object: the economy of agriculture of the RSO. The scientific novelty of the research is determined by the provisions revealing (1) the results of the analysis of criteria, endogenous and exogenous factors affecting the development of South Ossetia, (2) determining the directions of improving the organizational and economic mechanism of agricultural development in the RSO, based on endogenous and exogenous factors, (3) characteristics of the economic -institutional solutions to overcome barriers to intensifying the export of agricultural products, tourist services, etc.
CORPORATE FINANCE IN AN ECONOMIC ANALYSIS SYSTEM: GOVERNANCE, INTENSIFICATION, COMPETITIVENESS AND COST
Authors: Ostaev Gamlet , Il'in Sergey , Gogolev Igor' , Zlobina Oksana
Published: January 2021

Accounting and management information of a corporation in the current economic state of business should be useful for forecasting, planning, regulation, analysis and control, i.e. act as an important link in managerial decision-making.

The article contains material that includes the author's development of tools for the formation of a system of indicators intended for an objective assessment of the intensification of corporate finance, which for them, as the main economic entities of large business, is a key factor in competitiveness and leadership in their market segments. This system is built through the interaction of the resulting indicators (changes in the result (profit) and changes in costs (expenses)) with direct and indirect indicators of the efficiency of corporate finance without taking into account (generalized) and taking into account their differentiation (detailed), based on cash receipts and payments, according to controlled (economic processes) and uncontrolled (micro-environment and macro-environment) operating conditions. It is aimed at helping corporations to obtain financial benefits while combining the maximum possible increase in profits and reducing costs (monetary savings) in aggregate and in the context of their individual elements in operational terms through a holistic and organic analysis of the selected resulting and factor indicators that characterize the effectiveness (direct profitability ) and the cost (indirect profitability) of the activities carried out by them in their multidirectional and vast business environment.
THE HUMAN ECOLOGY OF A FORMER STATE-OWNED-ENTERPRISE IN WESTERN ANATOLIA
Authors: Çaya Sinan
Published: January 2021

This article is basically the retrospective investigation of a Turkish State-owned pulp-and-paper plant, in the time interval of 1979-1981. At the time, the mixed economy understanding prevailing, many industrial installations were operated by the government in Turkey. Along the course of privatizations the vast majority of such institutions have changed hands and the few remaining ones are also on the same way.
Pelatihan Teknik Pengolahan Ikan Lele Asap Dengan Alat Pengasap Ikan Portable Bagi Pengurus Pimpinan Cabang Muhammadiyah (PCM) Pontianak Tenggara dan UMKM Kota Pontianak
Authors: Raharjo Eka Indah , Hariyanto Dedi
Published: January 2021

Kegiatan pengabdian kepada masyarakat ini bertujuan untuk melatih kelompok masyarakat membuat produk ikan lele asap menggunakan alat pengasap ikan portable di masing-masing kelompok masyarakat dengan panjang alat 30 cm, lebar 20 cm dan tinggi 65 cm. Metode kegiatan yang diterapkan adalah 2 tahap yaitu tahap pertama dengan cara caramah (penyuluhan dan diskusi yang terarah) dan tahap kedua disertai dengan demontrasi atau praktek secara langsung dilapangan dalam pembuatan produk ikan lele asap menggunakan alat pengasap ikan portable. Kegiatan ini melibatkan 4 (empat) kelompok masyarakat secara aktif mulai dari kegiatan persiapan alat dan bahan, sampai ke proses pengolahan ikan lele menjadi ikan lele asap. Melalui kegiatan tersebut, kelompok masyarakat berhasil membuat produk ikan lele asap di masing-masing kelompoknya yang siap packaging sebagai usaha alternatif untuk di konsumsi dan dipasarkan secara meluas.
Edukasi Pencegahan Risiko Diabetes Melitus Pada Masyarakat di Pematang Bandar Simalungun
Authors: Nasution Fitriani , Andilala Andilala , Siregar Ambali Azwar , Safrina Safrina
Published: January 2021

Upaya pemerintah Indonesia dalam pengendalian penyakit Diabetes Melitus (DM) yaitu saat ini fokus pada pengendalian faktor risiko DM melalui upaya promotif dan preventif, rendahnya pengetahuan masyarakat mengenai penyakit DM, pencegahan, penatalaksanannya secara nonfarmakologis atau perubahan gaya hidup dan rendahnya pengetahuan tentang pola makan untuk mengendalikan kadar gula darah sehingga perlu dilakukan edukasi dalam meningkatkan pengetahuan masyarakat. Kegiatan ini bertujuan untuk memberikan informasi kepada masyarakat di Pematang Bandar Simalungun tentang pencegahan penyakit Diabetes Melitus, pola makan sehat, dan pemeriksaan kadar gula darah. Metode dilakukan dengan ceramah, diskusi dan tanya jawab sedangkan media menggunakan LCD dan powerpoint. Edukasi yang disampaikan meningkatkan pengetahuan masyarakat tentang pencegahan penyakit diabetes melitus dan pola makan sehat, sehingga masyarakat secara mandiri dapat mencegah risiko penyakit diabetes melitus yang merupakan salah satu penyakit degeratif yang diramalkan akan meningkat setiap tahunnya. Diharapkan pengabdian selanjutnya dapat memberikan informasi mengenai teknik olahraga dalam mencegah risiko DM.