bluuebunny/crossref_metadata_2025 huggingface dataset:
Kooperatywy mieszkaniowe w Zurychu – ponadczasowa odpowiedź na współczesne wyzwania mieszkalnictwa
Authors: Pabich Marek , Bamberski Michał
Published: September 2022

Artykuł przedstawia pojęcie społecznego budownictwa oddolnego, ze szczególnym uwzględnieniem kooperatyw mieszkaniowych w kontekście miasta Zurych, oraz opisuje współpracę jej członków z władzami miasta w celu stworzenia dostępnej
i atrakcyjnej zabudowy mieszkaniowej, dopasowanej do konkretnych potrzeb przyszłych lokatorów. Proces tworzenia budynków kooperatyw mieszkaniowych został przeanalizowany na podstawie dwóch unikatowych przykładów osiedli w Zurychu. Celem artykułu jest przedstawienie czynników definiujących wysoką jakość zamieszkania w mieście oraz prezentacja procesu realizacji kooperatyw mieszkaniowych. Przyjęta metodologia polegała na połączeniu analizy tekstów źródłowych oraz ocenie empirycznej.
Fundamentos teóricos de una estrategia educativa para desarrollar la comunicación asertiva en estudiantes.
Authors: Vera Cedeño María Pilar , Caballero Vera Hernán Humberto
Published: September 2022

En la formación académica es importante desarrollar la comunicación asertiva, la cual debe de ser desarrollada de la mejor manera para que los estudiantes puedan comunicarse con mayor facilidad y se den a comprender en sus intervenciones diarias. El no saber hacer uso de la comunicación asertiva trae consigo dificultades académicas, sociales y familiares. El presente trabajo tuvo como objetivo elaborar una estrategia educativa basada en actividades lúdicas, para desarrollar la comunicación asertiva en los estudiantes La metodología en esta investigación se basó en el enfoque cuantitativo con un diseño no experimental, de tipo transversal. El alcance de la investigación es de tipo descriptivo. Sobre los métodos seleccionados, constan de nivel teórico como el histórico-lógico, el hipotético-deductivo y el análisis-síntesis. Entre los métodos de nivel empírico, están la medición científica y el análisis documental. También métodos de nivel estadístico-matemático, como la estadística descriptiva. En efecto, la población era de 89 estudiantes y se obtuvo estratos de los años de Educación Básica Superior, basado en una muestra de 72 escolares, de la Unidad Educativa Vicente Rocafuerte del cantón Portoviejo. Entre los principales resultados teóricos que se analizaron se comprende que varios autores señalan que la comunicación asertiva es parte de los valores que el ser humano adquiere y demuestra en su accionar diario, lo que permite que el estudiante pueda manifestarse de manera asertiva ante el colectivo en general. Para finalizar es preciso enfatizar sobre la importancia y significancia de la comunicación asertiva en los estudiantes de la básica superior, así mismo fortalecer la comunicación entre docentes, padres de familia y comunidad educativa en general.
Sistemas de Monitoreo de Salud Estructural de Estructuras Civiles: una revisión bibliográfica.
Authors: Bacuilima Illescas Mauricio Andrés , Barbecho Chuisaca Juan
Published: September 2022

En la actualidad el monitoreo de salud estructural (SHM) es considerado como un campo de investigación emergente, este permite identificar el estado de salud de una estructura a través del monitoreo del comportamiento estructural, el sistema identifica defectos y daños de una estructura de manera temprana, sin importar que la estructura se encuentre en etapa de construcción o funcionamiento. SHM ha sido aplicado en múltiples estructuras a nivel mundial, desde hace muchas décadas, lo que ha permitido la investigación y el desarrollo de tecnologías eficientes y accesibles. Los resultados obtenidos con la aplicación de SHM han demostrado que es una herramienta que permite una operación segura y una administración eficiente de la estructura, ya que al tener un diagnóstico temprano del estado de salud es posible enfocar los esfuerzos de mantenimiento en los defectos y daños identificados antes de que estos sean visibles a los métodos convencionales, optimizando de esta manera el uso de recursos utilizados en el mantenimiento y potenciación de la infraestructura. Las principales aplicaciones se las ha realizado en estructuras importantes donde no es económicamente viable su reemplazo, sin embargo, su aplicación también es posible en estructuras pequeñas.
Hva har 20 år med nullvisjon i trafikken lært oss?
Authors: Aarvold Rita Helen , Raanes Guro
Published: September 2022

Nullvisjonen innenfor veitrafikk ble innført i Norge for over 20 år siden og har siden da ligget til grunn for alt trafikksikkerhetsarbeid. Visjonen bygger på tre grunnpilarer: etikk, kunnskap og delt ansvar. Introduksjonen av nullvisjon førte til et viktig skifte i arbeidet med trafikksikkerhet og har bidratt til at det har blitt mer systematisk, helhetlig og målrettet med fokus på effektive, kunnskapsbaserte tiltak. Samlet sett, har trafikksikkerhetsarbeidet siden nullvisjonen ble vedtatt, bidratt til en betydelig nedgang i antall drepte og hardt skadde. Antall drepte er redusert med nær 70 % og hardt skadde med nær 50 %. I denne perioden har vi etablert og erfart viktige suksesskriterier og læringspunkter om hvordan vi skal jobbe med vår nullvisjon. Nullvisjon kan overføres til andre områder enn trafikksikkerhet, men hvert område må finne hvordan den skal operasjonaliseres og implementeres innen deres område.
Kjære leser
Authors: Mehlum Lars
Published: September 2022

Vi er midtveis i Regjeringens handlingsplan for forebygging av selvmord – en handlingsplan som fastsetter en nullvisjon for selvmord i det norske samfunnet. Det kan ikke bety annet enn at målet er å avskaffe selvmord i vårt land. Naturlig nok har det vært mye debatt om hvorvidt en slik nullvisjon er en god ting og om den er realistisk. Men mange sympatiserer med den høye målsettingen som ligger implisitt i denne visjonen. Jeg tilhører selv dem som sympatiserer. For dersom vi ikke skal ha en nullvisjon, hvilken visjon skal vi da ha? Hvor mange selvmord skal vi da anse som et akseptabelt antall i Norge? Og hvilke selvmord skal vi ikke forebygge? Vanskelige spørsmål som det ikke finnes enkle svar på. Kanskje svaret er at selv om vi ikke kan vedta å avskaffe selvmord, kan kanskje en nullvisjon bidra til at flere mennesker som vurderer å ta sitt eget liv får flere gode valgmuligheter og på dette grunnlaget velger å leve videre.

Samtidig er det klart at en nullvisjon for selvmord legger opp til et høyere nivå av forpliktende innsats i selvmordsforebyggingen enn hva som er tilfellet i dag. Det gjelder ressurser og innsats både fra myndigheter, fagfolk og menigmann. Vi satser i dag langt mindre på selvmordsforebygging enn på andre alvorlige samfunnsproblemer. Under pandemien så vi hvilken formidabel innsats og hvilke kolossale ressurser som ble satt inn for å beskytte samfunnet og enkeltmennesker når det var nødvendig. Vår evne til å svare på alvorlige trusler mot liv og helse er svært stor, bare vi innser hvor alvorlig problemet er. Men det gjenstår mye før vi kan si at vårt samfunn har skjønt alvoret når det gjelder selvmord.

Slik er det ikke når det gjelder forebygging av trafikkdød. For om lag 20 år siden var antall trafikkdrepte og hardt skadde i trafikken langt høyere enn i dag. Etter at Stortinget fastsatte en nullvisjon på dette feltet, arbeidet vegmyndighetene hardt og systematisk for å få ned tallene, og dette har båret frukter. I dette nummeret av Suicidologi beskriver Aarvold og Ranes de viktigste lærdommene fra dette forebyggende arbeidet og hvordan man har oppnådd en nærmere 70 % reduksjon i antall trafikkdrepte. Vi tror disse erfaringene har mye å lære oss når det gjelder selvmordsforebygging og hvordan virkeliggjøre en nullvisjon. Hardt, målrettet og systematisk arbeid over tid er det som må til, sammen med vilje til å bevilge nødvendige ressurser. Dette har båret frukter andre steder, blant annet i delstaten New York i USA, som vi også bringer stoff fra i dette nummeret. God sommer!
Die evolusie van eietydse intelligensie en die rol van sosiale-media-intelligensie (Socmint)
Authors:   Noordwes-Universiteit, Stegen Ansie , Duvenhage André ,   Noordwes-Universiteit
Published: September 2022

Die afgelope aantal dekades is die internasionale sekerheidslandskap gekompliseer deur die snelle ontwikkeling van nuwe kommunikasietegnologie. Hierdie tegnologie hou nie net gevolge in vir die samelewing in die algemeen nie, maar ook vir politieke strukture en die intelligensiegemeenskap in die besonder. Dit is veral die ontwikkeling van sosiale media binne die kommunikasie-omgewing wat ’n besondere uitdaging aan die intelligensiegemeenskap stel. Dit het ’n nuwe bron van inligting, naamlik sosiale-media-intelligensie (Socmint), tot gevolg gehad, met verreikende implikasies vir die spelreëls ten opsigte van intelligensie in al sy vorme en toepassings. Hierdie nuwe bron van inligting kan ’n belangrike rol in die intelligensieproses vertolk. Die ontwikkeling hou implikasies in vir intelligensiedienste wêreldwyd, maar ook vir die Suid-Afrikaanse intelligensie-omgewing wat met sy eiesoortige stel uitdagings te kampe het.
Onderwys in die skaduwee van die Antroposeen. Kritiese posthumanistiese eksperimentering
Authors:   Universiteit van Suid-Afrika, Postma Dirk
Published: September 2022

Hierdie artikel het ten doel om ’n kritiese posthumanistiese konsep van die onderwys te ontwikkel wat ’n antwoord kan bied op die bedreigings van die Antroposeen deur te eksperimenteer met maniere van wording-met-ander. Die Antroposeen is moontlik gemaak deur opvattings en praktyke wat spruit uit die humanistiese aanvaarding van die uniekheid en meerderwaardigheid van die mens. Die manier waarop mense en die natuur uitgebuit word tot voordeel van diegene wat die markte beheer, lei tot die Antroposeen. Die geloof dat die mens in beheer is, het onvermydelik gelei tot die krisistoestand van die Antroposeen waar sy eie voortbestaan bedreig word. In teenstelling met hierdie humanistiese opvattings aanvaar posthumanisme die verweefdheid en interafhanklikheid van die mens met die vele ander lewendes en nielewendes. Kritiese posthumanisme toon aan hoe die gesentreerde mens ’n heersersposisie ingeneem het deur mag van die vele andere te versamel. Kritiek is ’n performatiewe aksie waardeur ’n ander manier van wording verwerklik word. Dit is belangrik om die opvoedkundige implikasies van posthumanisme te ondersoek, aangesien die onderwys nog steeds ’n sentrale deel uitmaak van die humanistiese projek. Die fokus op die onderwys is ook belangrik, omdat dit ’n bydrae lewer tot die ontwikkeling van ’n posthumane subjektiwiteit. Die betekenis van hierdie subjektiwiteit word vervolgens deur middel van relevante studies ondersoek. Een van die studies spoor die netwerke na wat ’n alledaagse handeling moontlik maak. Deur hierdie nasporing ervaar die studente in hierdie studie hulle verbintenis met en erkentlikheid teenoor vele lewende en nielewende andere. In ’n ander studie word gekyk hoe vroeë-onderwys-kinders met hulle eie liggame, lig en kostuums eksperimenteer. Hieruit kon gesien word hoe vloeibaar menslike wording is en wat die waarde van eksperimentering vir alle vlakke van die onderwys kan wees.
Aantekening: Denkbeeldige insetbelasting op tweedehandse vaste eiendom: Te goed om waar te wees, of nie goed genoeg nie?
Authors: Botes Marlene
Published: September 2022

While it might sound too good to be true, an input tax deduction may in certain circumstances be claimed even where no value-added tax (VAT) is paid. To prevent double taxation in respect of second-hand goods, a VAT vendor who purchases such goods without paying VAT may make a deduction of notional input tax of, generally speaking, the trapped VAT portion of its purchase price. As only its margin (namely the difference between its purchase and selling prices) will, effectively, be subject to VAT, this also ensures that VAT is levied only where value is added by a VAT vendor. However, the entitlement to a deduction of notional input tax has resulted in unacceptable VAT avoidance and evasion by way of the creation of artificial structures to qualify for the deduction or to fraudulently inflate the amount of the deduction. Although the incentive for such structures relating to fixed property has largely been eliminated by various VAT amendments, exploitation has also been experienced in respect of other second-hand goods. On the one hand, this raises the question whether the policy objectives are worth the inherent risk of non-compliance and the effort to protect the integrity of the VAT system and the fiscus. On the other hand, when a VAT vendor has to pay transfer duty, it is not allowed to take the transfer duty into account when calculating its notional input tax. The purpose of this note is to provide an overview of the circumstances when notional input tax may be claimed, to reflect on the policy objectives thereon, the exploitation thereof and the sanctions imposed to protect the fiscus, in order to evaluate whether the concession is too good to be actually true and, should it be justifiable, to call for an interpretation in line with the policy objectives and to submit that amendments should be introduced to ensure that the concession is good enough.
People’s Power: Local Agency among HIV AND AIDS Marginalized Groups in Mbozi District, Tanzania, 1980s-2017
Authors: Sadock Musa
Published: September 2022

This study examines the Mbozi society`s responses to the plight of marginal groups attributed to HIV/AIDS for the past three decades. The groups in question include people suffering from and or living with HIV/AIDS, AIDS related widows, AIDS orphans, and the elderly caring AIDS orphans. Rather than focusing synchronically on the responses from the international community, government and Non-governmental organizations as has been done by many studies, this study diachronically concentrates on the ordinary people`s responses at the grass-roots level. It argues that to cope with their plight, marginal groups associated with HIV/AIDS engage in different livelihood strategies including wage-labour, begging, sex work, petty trade, income generating groups, self-help groups, farming as well as enlisting family and neighbourhood support. By drawing on documents and interviews with people at the grass-roots level, this study not only brings to the fore the voices of the marginalized and people`s agency and resilience in the context of HIV/AIDS pandemic but it also adds to the growing body of knowledge on social exclusion in Tanzania in particular and Africa as a whole.
Income Inequality in Nepal
Authors: Raj Dhungel Kamal
Published: September 2022

Income inequality refers to a situation in which most of the national income is being distributed unevenly. Nepal is a small country with a population of nearly 30 million. It consists of a diverse society with disparity in health, education, opportunities, and income. The disparity in income distribution is measured with the help of Gini Coefficient with value ranges from zero (absolute equality) to 1 (absolute inequality). Presently the Gini coefficient of Nepal is 0.4. It indicates a big inequality in the distribution of the national income pie of Nepal in which a small portion of the population say the upper 10 percent are getting a big chunk of national income.
Desain Pengembangan Tari Serampang 12 Sebagai Media Pembelajaran Etnomatematika Materi Geometri Transformasi
Authors: Anggi Pratiwi Siska , Mushlihuddin Rahmat
Published: September 2022

Kesulitannya pemahaman konsep oleh peserta didik salah satunya disebabkan karena matematika mempunyai tingkat keabstrakan yang tinggi sehingga peneliti mendesain sebuah media pembelajaran berbasis media pembelajaran etnomatematika. Penelitian ini bertujuan untuk menghasilkan desain pengembangan tari serampang 12 sebagai media pembelajaran etnomatematika. Penelitian ini adalah merupakan penelitian pengembangan (RnD) menggunakan model 3-D yaitu tahap pendefinisian (define), tahap perancangan (design), dan tahap pengembangan (develop). Instrumen penelitian adalah angket uji kelayakan ahli. Berdasarkan hasil validasi ahli, dari hasil penilaian akhir pada kelayakan tari serampang 12 sebagai media pembelajaran etnomatematika oleh ketiga ahli dengan rata-rata skor 3,53 dengan persentase 88,38% memenuhi kriteria layak. Berdasarkan data tersebut dapat disimpulkan bahwa desain pengembangan tari serampang 12 sebagai media pembelajaran etnomatematika materi geometri transformasi layak digunakan.

 

Kata kunci : Desain Pengembangan, Tari Serampang 12, Media Pembelajaran Etnomatematika.
Pengembangan E – Modul Sebagai Bahan Ajar Alternatif Siswa Pada Materi Himpunan di SMP Muhammadiyah 8 Medan
Authors: Nur Pasiuli Harahap Rona
Published: September 2022

Jenis penelitian ini menggunakan pengembangan Research and Development (R&D). Penelitian pengembangan ini dilakukan untuk menghasilkan produk serta mengetahui validitas, respon siswa terhadap E – modul sebagai bahan ajar alternatif siswa yang telah dihasilkan. Produk ini dikembangkan dengan menggunakan model ADDIE yang dimodifiksi menjadi 3 tahap yaitu analisis (analysis), perancangan (design), serta pengembangan (development). Penelitian ini mengembangkan E – modul Matematika Sebagai Bahan Ajar Alternatif Siswa Pada Materi Himpunan Di SMP Muhammdiyah 8 Medan. Subjek dari penelitian ini merupakan siswa kelas VII – SMP yang terdiri dari 10 siswa, dimana peneliti memilih responden berdasarkan skala kecil. E – modul yang telah dibuat memehuni kriteria kevalidan yang ditunjukan dengan menggunakan lembar validasi ahli media dan ahli materi. Hasil validasi ahli media mencapai skor rata-rata 3.06 dengan kriteria “valid”, serta hasil validasi ahli materi mencapai skor rata- rata 3.15 dengan kriteria “valid”. Aspek kemenarikan berdasarkan respon siswa mencapai skor rata-rata 3.43 dengan kriteria “menarik”. Berdasarkan hasil penelitian serta pembahasan yang telah dilakukan, dapat disimpulkan bahwa e – modul matermatika sebagai bahan ajar alternatif siswa pada materi himpunan layak dan menarik untuk digunakan yang ditinjau dari aspek kevalidan dan respon siswa.
Desain Pengembangan Tari Zapin Berbasis Hots Pada Materi Bangun Datar Berbantuan Tangram
Authors: Rahmayani Tanjung Ika
Published: September 2022

Rendahnya kemampuan siswa pada mata pelajaran matematika pada materi bangun datar disebabkan oleh rendahnya cara berpikir siswa dan metode penyampaian guru sehingga peneliti merancang suatu alat peraga. Penelitian ini bertujuan untuk menghasilkan desain tari zapin berbasis hots pada bentuk datar berbantuan tangram. Penelitian ini (RnD) menggunakan model 3-D yaitu tahap definition, design dan development. Instrumen penelitian adalah angket tes. Berdasarkan hasil validasi ahli dari hasil penilaian akhir pada IPPP-1 oleh ketiga ahli dengan skor rata-rata 3,40 dengan persentase 85,01% memenuhi kriteria kelayakan. Berdasarkan data-data tersebut, dapat disimpulkan bahwa desain pengembangan tari zapin berbasis hots pada material datar berbantuan tangram.
Parents and Children's Perceptions of Online Learning During the Covid-19 Pandemic in East Alok District
Authors: Indrayani Fitria
Published: September 2022

The purpose of this study is to know the perception of parents and children about learning online during Pandemi Covid-19 in East Alok District. This research was conducted in Nangameting Village. RT 002 and Waioti Village RT 038 Alok Timur District. This study uses data collection techniques, descriptive qualitative methods with interview techniques with 68 respondents. The results of the interview of parents and children reveal that online learning is felt ineffective, namely children bored, the performance of children is affected, children do not understand the task, and material is inadequate. For reasons such as given by the teacher, children play and children who are not focused. In addition, parents must also accompany children in online learning. This was also stated by children who felt online learning was ineffective because they felt difficulties in understanding the material and tasks given by their teachers during the online learning process. Cannot meet directly with the teacher, too many tasks, and lack of knowledge about how to use applications. Obstacles between parents and children in online learning, internet quota used by children to play, Android phones do not exist, children do not understand material and tasks, limited economy, expensive quota, limited parental education, unstable networks, and do not understand how to use application
Use of the Google Classroom Application in Learning Pandemi Covid-19 at SMAS Muhammadiyah Maumere
Authors: Irmawati Theresia Antonia
Published: September 2022

This study aims to determine the use of the Google Classroom application and its constraints in learning the Pandemic Covid-19 at SMAS Muhammadiyah Maumere. This research was conducted at SMAS Muhammadiyah Maumere in semester 2 of the 2021/2022 school year. The data source in this study was students and teachers in SMAS Muhammadiyah Maumere. The research method that the researcher uses is a descriptive method with data collection techniques, namely using interviews. Based on the results achieved in this study, it can be seen that, the use of the Google Classroom application in SMAS Muhammadiyah Maumere is the use of the Google Classroom application in learning the Pandemi Covid-19 is already running well, easy to use by teachers and students, the application can also used anywhere and easy to send material and tasks. Constraints faced in the use of the Google Classroom application in learning Pandemi Covid-19 are students who do not understand the material provided, it is difficult to get extensive knowledge, tasks given by teachers are difficult to download and their internet networks are limited. While the obstacle faced by the teacher is that many students do not collect timely assignments and the internet network is limited
Variation of cytochrome oxidase-I gene and venom proteins of Rhopalurus junceus populations in the Moanicum sector: Pharmacological implications
Authors: Rodríguez-Ravelo Rodolfo , Ruíz-Urquiola Ariel , Possani-Postay Lourival D. , Morris-Quevedo Humberto J. , Rodríguez-Ravelo Magdelaine , Espinosa-López Georgina
Published: September 2022

Context: In Cuba, the venom of the endemic scorpion Rhopalurus junceus has been used in traditional medicine for cancer treatment. The genetic variability in populations from distinct origin and differences in the composition of venom –a little explored topic- could influence the pharmacological effects of products used in medical practice. Aims: To characterize the populations of R. junceus from six different districts of the Moanicum sector in northeastern Cuba, taking into account the variations in the sequences of cytochrome oxidase subunit I gene (COI) and peptide masses of venom. Methods: For the genetic characterization, a 658 bp gene fragment of COI was amplified by PCR. The genetic structure of populations was analyzed hierarchically, using an analysis of molecular variance (AMOVA). In proteomic analysis, molecular masses of venom constituents were arranged in increasing order, and different components were considered when masses differed by 2 Da. Results: R. junceus species in the six districts studied in the Moanicum sector belong to different populations. The sequences of COI gene showed high levels of genetic variability, recovering 47 haplotypes (87% unique). The composition of the venom was also significantly different between the districts. The most abundant components presented masses of 3-6 kDa (K+-channel specific peptides) and 6,1-10 kDa (Na+-channel specific peptides). Conclusions: Populations of R. junceus showed high genetic differentiation and a broad intraspecific variation in the venom peptides (3-10 kDa) in six districts of Moanicum sector of Cuba. This richness in scorpion varieties with different toxins profile should be considered for pharmacological applications.
In utero exposure to Hypoxis hemerocallidea Fisch., C.A.Mey. & Avé-Lall. improves metabolic syndrome parameters in pregnant rats and offspring
Authors: Sewani-Rusike Constance R. , Buso Andiswa , Engwa Godwill A. , Nkeh-Chungag Benedicta N. Nkeh-ChungagBenedicta N.
Published: September 2022

Context: Intrauterine and early life environments contribute to adult metabolic phenotype. Use of medicinal plants like Hypoxis hemerocallidea during pregnancy raises the question of whether this species may have epigenetic benefits or detriments due to intrauterine-programming, which is phenotypically expressed in the offspring. Aims: To evaluate the effect of H. hemerocallidea on selected markers of metabolic syndrome on dams and their pups (offspring). Methods: Pregnant female Wistar rats (n=18) were divided into three treatment groups (n=6/group): Ethanol extract of H. hemerocallidea at 150 and 300 mg/kg b.w and the control (distilled water) were administered for 21 days. Body weights were monitored and oral glucose tolerance was determined for dams on day 20 of gestation and for pups 28 days postpartum. Serum total antioxidant capacity (TAC), LDL and HDL were determined 28 days postpartum. Results: H. hemerocallidea had no effect on body and organ weights of the treated dams. Pups born to H. hemerocallidea dams had reduced visceral fat compared to the untreated controls. H. hemerocallidea increased the glucose tolerance of treated dams and their pups compared to untreated controls. H. hemerocallidea extract increased serum HDL in treated dams while it decreased LDL in pups born to treated dams. H. hemerocallidea increased TAC in pups born to treated dams. Conclusions: H. hemerocallidea protected pregnant dams and their pups from insulin resistance, improved lipid profiles, reduced visceral fat accumulation and boosted total antioxidant capacity in pups. These protective effects of H. hemerocallidea in pups may have resultedfrom intrauterine programming during pregnancy.
Aceite de hígado de tiburón microencapsulado: Desarrollo de una formulación de cápsulas duras
Authors: García Peña Caridad M. , Fernández Cervera Mirna , Castiñeira Díaz Mirta , López Hernández Orestes D. , Martínez Espinosa Vivian , Nogueira Mendoza Antonio
Published: September 2022

https://jppres.com/jppres/aceite-de-higado-de-tiburon-microencapsulado/#:~:text=Context%3A%20The%20recognized%20properties,stability%2C%20for%2024%20months.
Antioxidant and anti-advanced glycation end products formation properties of palmatine
Authors: Mridula Sharma , Masroor Wardah Siddiqui , Xavier Mellinnda , Hui Tan Wen , Chan Hor Kuan , Chirara Kavita , Nwabueze Okechukwu Patrick
Published: September 2022

Context: Oxidative stress and formation of advanced glycation end products (AGEs), due to glycation of proteins, lipids and nucleic acids are characteristic in diabetic patients. Palmatine, a protoberberine alkaloid bioactive isolated from Coscinium fenestratum (CF) stem extract, which previously has shown to possess antidiabetic and antioxidant properties and to be able to protect the kidney and liver in a STZ-diabetic induced rat model. Aims: To evaluate the in vitro and in vivo antioxidant and anti-AGE activity of palmatine. Methods: In vitro and in vivo studies were conducted to measure radical scavenging, reducing power, inhibition of lipid peroxidation, carbonyl trapping and metal ion chelation. In vitro antiglycation activity was done using bovine serum albumin-methylglyoxal (BSA-MGO), bovine serum albumin – glucose (BSA-GLU) and glycated hemoglobin. In vivo antioxidant and antiglycation activity were used to evaluate liver and kidney extracted from STZ-induced diabetic rat after treatment with palmatine. Results: The results showed palmatine blocked the formation of AGE as shown by the results of BSA-GLU, BSA-MGO, glycated hemoglobin and inhibited the free radicals generated by DPPH, nitric oxide, hydrogen peroxide, lipid peroxidation, FRAP and metal ion chelating. It was able to stimulate in vivo the activity of catalase, super oxide dismutase and glutathione peroxidase. Conclusions: Palmatine possess antioxidant and antiglycation properties, the mechanism of action seems to be via the blockage of free radical formation, decreasing of reactive carbonyl. Further research is ongoing to determine the effect of palmatine on glyoxalase 1 and aldose reductase pathway and interaction with receptor for AGE.
The role of reduced glutathione on oxidative stress, reticulum endoplasmic stress and glycation in human lens epithelial cell culture
Authors: Handayani Nina , Permatasari Nur , Sujuti Hidayat , Rudijanto Achmad
Published: September 2022

Context: Cataracts are currently the main cause of blindness worldwide. This condition caused by a low concentration of reduced glutathione (GSH) in the lens. Aims: To evaluate the effect of glutathione (GSH) on the hyperglycemia-induced oxidative stress, reticulum endoplasmic stress, and glycation in human lens epithelial cells. Methods: Human lens epithelial cells were cultured under high-glucose conditions. Malondialdehyde (MDA), protein carbonyl content (PCC), glucose reactive protein (GRP), and advanced glycation end product (AGE) were measured by enzyme-linked immunosorbent assay after 72 h of incubation for MDA, PCC, GRP and after 2 weeks incubation for AGE. Results: The MDA and PCC levels increased in response to high-dose glucose administration compared to the control group. MDA and PCC levels were decreased at all GSH doses, whereas the lowest mean MDA and PCC levels were observed at GSH doses of 10 and 100 μM, respectively. GRP levels increased after high-glucose administration as compared to the control group. Additionally, the groups co-treated with 30 and 100 μM GSH showed reduced PCC. The AGE level was reduced at all doses of GSH compared to those in the control group. Conclusions: The results suggest that GSH inhibits oxidative stress, reticulum endoplasmic stress, and AGE formation, which may lead to the progression of diabetic cataract. Additionally, GSH may maintain lens transparency by acting as an antiglycation and controlling the AGE formation.
Seguridad del nimotuzumab luego de ensayos clínicos en tumores epiteliales de cabeza y cuello
Authors: Clapé-Laffita Oneyda , Perrand-Roberts María V. , Domecq-Salmon Milagros , Rodríguez-Alfaro Maryenis , Cebreco-Sardina Maritza
Published: September 2022

Context: Immunotherapy, by directing the immune response against tumor cells, complements the oncological therapy along with conventional treatments. Thus, the monoclonal antibody nimotuzumab blocks the binding of epidermal growth factor to its receptor, interfering with cell proliferation in epithelial tumors, such as those of the head and neck. Aims: To evaluate the safety of nimotuzumab after concluded the clinical trials in epithelial tumors of the head and neck, analyzing the relation with the therapeutic compliance for the patients. Methods: A retrospective descriptive study was carried out, characterizing nine patients with epithelial tumors of the head and neck, who continued to use nimotuzumab after concluding clinical trials; and evaluating adverse effects according to severity, intensity, causality, and frequency, thus establishing the safety of this medicine. The compliance of nimotuzumab therapy was analyzed, by reviewing the administration intervals to the received doses. A descriptive statistical analysis was performed. Results: In the studied sample men predominated (eight patients: 88.89%), without significance differences in age and race. All were diagnostic with epidermal carcinomas, predominated the good differentiated (six patients: 66.67%). Five adverse effects were detected in two old patients (all not serious, light or moderate, and possible or probable, occasional or frequent), evaluating to nimotuzumab as safe medication. There was inadequate therapeutic compliance to treatment, not relation with the presented adverse effects. Conclusions: Nimotuzumab represented a safe drug after concluded the clinical trials in patients with epithelial tumors of the head and neck, without relation with the existed inadequate therapeutic compliance.
Insulin expression and insulitis degree of diabetic rats after giving sikkam leaves (Bischofia javanica Blume)
Authors: Rumahorbo Cheryl GP. , Hutahaean Salomo , Ilyas Syafruddin
Published: September 2022

Context: Gallic acid and quercetin in sikkam leaves (Bischofia javanica) have scientific potential as antidiabetic agents. Quercetin suppresses hyperglycemia by inhibiting active glucose transport. Meanwhile, gallic acid acts as an antidiabetic is closely related to its antioxidant properties. Antioxidant compounds neutralize cells that experience oxidative stress by donating their hydrogen atoms. Aims: To analyze the degree of insulitis and insulin expression in the pancreatic cells of rats induced diabetes mellitus (DM) after giving B. javanica leaves extract. Methods: The treatment groups consisted of G0: negative control (-); G1: positive control (alloxan induction + standard feed); G2: alloxan induction + 300 mg/kg BW of B. javanica leaves ethanol extract; G3: alloxan induction + 600 mg/kg BW of B. javanica leaves ethanol extract; G4: alloxan induction + ethanol extract of B. javanica leaves 900 mg/kg BW and G5: alloxan induction + glibenclamide 4.5 mg/kg BW. At day 28, the rats were sacrificed, and the pancreatic tissue dissected. This was analyzed for degree of insulitis and insulin expression by anti-insulin antibodies using immunohistochemistry and hematoxylin-eosin. Results: There was a significant difference (p = 0.000) in insulin expression and insulitis degree. By the increase of B. javanica leaves dose, the insulin expression value also increased, and the degree of insulitis in Langerhans’ islets of DM rats was decreased. Islets of Langerhans in insulin production returned to normal after being given B. javanica ethanol extract 900 mg/kg BW like glibenclamide. Conclusions: Bischofia javanica ethanol extract increased insulin production and reduced the degree of insulitis in the islets of Langerhans histology. Further research is needed to determine the extent to which this extract protects from the sequelae of diabetes.
Tea catechin as antiviral agent via apoptosis agonist and triple inhibitor mechanism against HIV-1 infection: A bioinformatics approach
Authors: Kharisma Viol Dhea , Widyananda Muhammad Hermawan , Ansori Arif Nur Muhammad , Nege Aondohemba Samuel , Naw Sin War , Nugraha Alexander Patera
Published: September 2022

Context: Human immunodeficiency virus (HIV) antiretrovirals that target the binding of viral enzyme are chosen as the lead solution in the treatment of HIV-1 infection, such as non-catalytic site integrase inhibitor (NCINI), nevirapine, and darunavir. There are natural compounds from specific plants that can be effective in treating HIV-1 infection such as tea catechin. Tea catechin administration causes a decrease in viral load and inhibition of entry mechanisms and an increased effect of apoptosis in infected cells. Aims: To identify the triple inhibitor mechanism in tea catechins against the three HIV-1 enzymes and apoptosis agonists through in silico approach as an innovation in handling HIV-1 infection. Methods: The 3D structure of tea catechin compounds from the database was examined, and then all target compounds were analyzed for drug-likeness, molecular docking, pathway prediction, and molecular interactions to determine the potential of tea catechin compounds as antiviral HIV-1 in silico. Results: Tea catechin compounds have the potential to serve as antiviral against HIV-1 through apoptosis agonist and triple inhibitor mechanisms. Apoptosis occurs due to the interaction of tea catechins with pro-apoptotic proteins in cells, and the epigallocatechin gallate (EGCG) compound is a class of tea catechins with the same binding position as control. Conclusions: The binding of the EGCG molecule complex results in low binding energy. Therefore, it allows EGCG acts as a triple inhibitor in HIV-1 infection.
GENOCIDE OF LAW - the neoliberal neo-fascist mafia of the Chamber of Private Enforcement and its chairman Private Enforcement Agent GEORGI DICHEV in Bulgaria and the full support of this mafia from the prosecutor's office, court, Ministry of Justice, National Assembly, Bulgaria - The mafia has a state and union - THE EUROPEAN UNION - the support of the EUROPEAN UNION and the EUROPEAN COMMISSION, chaired by Barroso, Juncker, Ursula von der Leyen
Authors: Dobrev-Halachev Prince Lord Prof. Momchil
Published: September 2022

Lord prof PhD PhD Momtchil Dobrev-Halachev developed 2008 “Theory of generating of crises”, 2010 “Theory and practice of the Mafiotism” and 2001 “Theory of the mafia”. Based on these two theories this paper explains the establishment of mafiotismus all over the world - principles, theory and praxis in the European Union, European Commission and in the Republic of Bulgaria.
AKUNTABILITAS DAN TRANSPARANSI PENGELOLAAN ALOKASI DANA DESA (ADD) DI DESA MUARA PANCO TIMUR KECAMATAN RENAH PEMBARAP
Authors: Nadia Zein  , Addiarrahman  , Nurlia Fusfita
Published: September 2022

This study aims to identify and describe the implementation of accountability and transparency in the management of village fund allocations in Muara Panco Timur Village, Renah Pembarap District. The approach method in this research is descriptive qualitative. Sources of data used are primary data obtained by direct interviews and secondary data obtained from related documents. The results of this study indicate that the management of village fund allocations in Muara Panco Timur Overall, starting from accountability and transparency, it is quite good, but still has quite a lot of weaknesses and shortcomings. This is evidenced in the management of village fund allocations, the government has implemented the principle of accountability, namely by involving the community in planning the allocation of village funds (village deliberation), but only until the planning is carried out, the rest is carried out by the village government without involving village officials in managing village funds. then the application of transparency in accordance with the application of the three mechanisms, the application of transparency in the management of village fund allocations in the village of Muara Panco Timur is said to be not good, this is due to the lack of a government that implements the principle of transparency, namely by not fully involving the village community of Muara Panco Timur in managing village funds and lack of transparency in the management of village funds.
Estimation of Poisson Autoregressive Model for Multiple Time Series
Authors: Redondo Paolo Victor , Lansangan Joseph Ryan , Barrios Erniel
Published: September 2022

A Poisson autoregressive (PAR) model accounting for discreteness and autocorrelation of count time series data is typically estimated in the state-space modeling framework through an extended Kalman filter. However, because of the complex dependencies in count time series, estimation becomes more challenging. PAR is viewed as an additive model and estimated using a hybrid of cubic smoothing splines and maximum likelihood estimation (MLE) in the backfitting framework. Simulation studies show that this estimation method is at the least comparable to PAR estimated in the state-space context, especially with larger counts. The flexibility of the additive model has two significant benefits: [1] robust estimation in the presence of temporary structural change and [2] viability to integrate the PAR model into a more complex model structure. We further generalized the PAR(p) model into multiple time series of counts and illustrated it with indicators in the financial markets.
Health Risk Assessment of Trace Metals in the Vicinity of an Abandoned Mercury Mine in Puerto Princesa City, Philippines
Authors: Samaniego Jessie , Gibaga Cris Reven , Tanciongco Alexandria , Devanadera Ma. Catriona , Paro Fevi Rose , Adil Jihan , Montano Mariel , Quierrez Rico Neil , Gutierrez Alaine Claudette
Published: September 2022

Abandoned mines pose high risks to human health and the environment due to the disturbed and exposed metal-laden soils and sediments. In this study, soils and sediments in an abandoned mercury (Hg) mine in Puerto Princesa City, Philippines were analyzed to assess the potential adverse health effects of the exposure to trace metals associated with the mine wastes. A total of 63 soil and sediment samples were collected in the area and analyzed for Hg concentration using a direct Hg analyzer and inductively coupled plasma–mass spectrometry (ICP-MS) for other trace metals. Analysis results showed that aside from Hg, there are anomalous concentrations of Ni (nickel), Cr (chromium), and Mn (manganese) in the area brought by the value of the mineralogy of the ores that were mined. The measured trace metal concentrations, together with the United States (US) Environmental Protection Agency’s (EPA) exposure parameters and the US Department of Energy’s (DOE) toxicity values were used to calculate the dose contacted from different exposure pathways. The result of the health risk assessment showed that Hg was considered as the main contributor of non-carcinogenic risk in the area with a hazard index of > 1 for both children and adults. Inhalation of Hg vapor from the soils and sediments is found to be a significant addition to the health risks in the area. Other trace metals such as Co (cobalt), Fe (iron), Ni (nickel), and Tl (thallium) were calculated with a hazard index greater than 1, which poses a health risk to children due to the ingestion pathway. All carcinogenic trace metals assessed were below the guidance value, indicating no significant carcinogenic health risks for both adults and children in the area. This work serves as an initial step of the country in the assessment of the risks to human health and the environment brought by Hg contaminated areas, as stated in the Minamata Convention on Mercury.
Fatigue Estimation on a High-Speed Wave Piercing Catamaran During Normal Operations
Authors: Warren Mark , Ali-Lavroff J , McVicar J , Magoga T , Shabani B , Holloway D S , Thomas G
Published: September 2022

The estimation of fatigue life in the design process is particularly important for weight-optimised ships such as high-speed aluminium craft, but to date no research has been published on the fatigue accumulation on large wave-piercing catamarans, focusing on long-term operations. This paper assesses the applicability of classification society rules for high-speed catamarans with respect to fatigue design. This was achieved by comparing the long-term distributions of stress, measured on a 111m long wave-piercing catamaran ferry whilst operating in the Canary Islands and during the delivery voyage, with load spectra estimated using a method accepted by the classification society, DNV. The paper also proposes an improved distribution fitment method for fatigue analysis. A detailed method to convert measured stress histories in the time domain into an appropriate stress-spectrum and fitment of Weibull parameters is presented. Results show that the simplified method accepted by the classification society is highly conservative regarding fatigue estimation compared to fatigue results based on measured data. The proposed combined Weibull fitment method substantially improves the accuracy of simplified fatigue analysis methods.
Smart Technology Applied in The Management of Yachting Marinas
Authors: Radulovic Ana
Published: September 2022

The objective of this research is to analyse smart technologies implemented in marinas and their impact upon the safety and service quality improvement, sustainability, and environmental protection, as well as energy consumption and operations optimization. KPI and a definition of smart marina concept have been derived based on the smart port concept. The analysis has been conducted on a sample of 78 marinas. Ultimately, the scientific analysis has been performed in order to determine the advantages and disadvantages of introducing smart technologies in marina management. The results indicate that the marinas are undergoing a revolution in terms of facilitating booking management process and achieving greater safety and service quality, but still need to improve in the field of monitoring and controlling nautical tourism impact upon the environment.
Prediction for the 2020 United States Presidential Election Using Machine Learning Algorithm: Lasso Regression
Authors: Sinha Pankaj , Verma Aniket , Shah Purav , Singh Jahnavi , Panwar Utkarsh
Published: September 2022

This paper aims at determining the various economic and non-economic factors that can influence the voting behaviour in the forthcoming United States Presidential Election using Lasso regression, a Machine learning algorithm. Even though contemporary discussions on the subject of the United States Presidential Election suggest that the level of unemployment in the economy will be a significant factor in determining the result of the election, in our study, it has been found that the rate of unemployment will not be the only significant factor in forecasting the election. However, various other economic factors such as the inflation rate, rate of economic growth, and exchange rates will not have a significant influence on the election result. The June Gallup Rating, is not the only significant factor for determining the result of the forthcoming presidential election. In addition to the June Gallup Rating, various other non-economic factors such as the performance of the contesting political parties in the midterm elections, Campaign spending by the contesting parties and scandals of the Incumbent President will also play a significant role in determining the result of the forthcoming United States Presidential Election. The paper explores the influence of all the aforementioned economic and non-economic factors on the voting behaviour of the voters in the forthcoming United States Presidential Election.

 The proposed Lasso Regression model forecasts that the vote share for the incumbent Republican Party to be 41.63% in the 2020 US presidential election. This means that the incumbent party is most likely to lose the upcoming election.
„Immediate are the Acts of God, more swift than time or motion.“ Die literarische Adaption der augustinischen Vorsehungs- und Willenstheorie in John Miltons Paradise Lost
Authors: Drews Friedemann
Published: September 2022

Abstract. In his epic Paradise Lost, John Milton aims at a philosophically and theologically sound theodicy in order to “justify the ways of God to men”1. Milton’s approach has been criticised for creating an unsolvable tension between God’s foreknowledge and man’s free will and responsibility. The article wants to show that this criticism turns out to be unjustified if the philosophical basis behind the epic is thoroughly examined. Milton draws heavily on St. Augustine’s ontology: Every kind of being depends on its intrinsic goodness insofar as it really is what it is by nature. God himself is the ultimate goodness: Therefore he is not subject to change, but transcends space and time. In his perfection, he cannot lack any kind of knowledge, but knows all things in an atemporal manner, without depriving men and women of their capability of free choice and action, for these are the distinct features that constitute the goodness of human nature. The crucial question of the article is why, according to Augustine and Milton, God’s foreknowledge should not at all be confused with fated determinism.
Was macht Personen zu Personen?
Authors: Spaemann Robert
Published: September 2022

Abstract. What makes persons persons? In order to give an answer to this fundamental question, the article refers to central aspects of the concept of ‘person’. First, it takes the history of the concept into account, from its origins in Antiquity. Our understanding of persons is not based so much on the mask of ancient theatre but on the grammatical sense of ‘persons’ as mediated by patristical speculation on the Trinity. Then, regarding the modern debate on personal identity, it argues against John Locke and Derek Parfit that personal identity is not qualitative but numerical. In opposition to Peter Singer’s argument of Speciesism, the author maintains that belonging to the human species is a sufficient condition for the status of personhood. Finally, he defends for the thesis also held by Kant that if there is at all a rationally justifiable moment of the person’s coming to be, then that is the moment of conception.