bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis and Biological Evaluation of Prodrugs Based on the Natural Antibiotic Duocarmycin for Use in ADEPT and PMT
Authors: Tietze Lutz F. , Schmuck Kianga , Schuster Heiko J. , Müller Michael , Schuberth Ingrid
Published: January 2011

Chemotherapy of malign tumors is usually associated with serious side effects as common anticancer drugs lack selectivity. An approach to deal with this problem is the antibody‐directed enzyme prodrug therapy (ADEPT) and the prodrug monotherapy (PMT). Herein, the synthesis and biological evaluation of new glycosidic prodrugs suitable for both concepts are described. All prodrugs but one are stable in human serum and show QIC50 values (IC50 of prodrug/IC50 of prodrug in the presence of the appropriate glycohydrolase) of up to 6500. This is the best value found so far for compounds interacting with DNA.
Visible‐Light‐Induced Dye Degradation over Copper‐Modified Reduced Graphene Oxide
Authors: Xiong Zhigang , Zhang Li Li , Zhao Xiu Song
Published: January 2011

Previously, it was found that reduced graphene oxide (RGO) can degrade rhodamine B (RhB) under visible‐light irradiation, but with an extraordinarily slow rate. It was also found that modification of RGO with gold nanoparticles can dramatically accelerate the photoreaction rate. Herein, we describe the preparation and photocatalytic properties of copper‐ion‐modified RGO composite materials, which display a faster photocatalytic reaction rate and better mineralization under visible‐light irradiation than gold‐modified RGO. The copper‐ion‐modified RGO composites were prepared by an immersion method. The characterization results of X‐ray diffraction, transmission electron microscopy, field‐emission scanning electron microscopy, and X‐ray photoelectron spectroscopy show the presence of crystalline copper species Cu2(OH)3NO3 and Cu2(OH)3Cl on the surface of RGO. Modification of RGO with the copper species greatly enhances the degradation of RhB—after 3 hours of reaction under visible‐light irradiation, the total organic carbon is decreased by about 31 %. The copper species act as an electron relay, passing the excited electrons from the RGO sheets to adsorbed oxygen, thus leading to continuous generation of reactive oxygen species for the degradation of RhB.
ChemInform Abstract: Structural Topology and Chemical Bonding in Laves Phases
Authors: Ormeci Alim , Simon Arndt , Grin Yuri
Published: January 2011

theoretical study of M1M22 Laves phases
ChemInform Abstract: A Novel Bi‐Based Oxychloride CdBiO2Cl: Crystal Structure, Electronic Structure and Photocatalytic Activity.
Authors: Huang Fuqiang , Wu Jianjun , Lin Xinping , Zhou Zhen
Published: January 2011

CdBiO2Cl is synthesized by solid state reaction of BiOCl and CdO (alumina crucible, 700 °C, 24 h) and characterized by powder XRD, UV/VIS diffuse reflectance spectroscopy, and TB‐LMTO band structure calculations.
ChemInform Abstract: A Novel Photocatalyst and Improvement of Photocatalytic Properties by Cu Doping.
Authors: Sun Jingxue , Chen Gang , Li Yingxuan , Zhou Chao , Zhang Hongjie
Published: January 2011

Bi2Zn2/3‐xCuxTa4/3O7 (0.01 ≤ x ≤ 0.04) with pyrochlore structure is synthesized by solid state reaction of stoichiometric mixtures of Bi2O3, ZnO, Ta2O5, and CuO (850 °C, 15 h).
ChemInform Abstract: Preparation, Characterization, and Structural Phase Transitions in a New Family of Semiconducting Transition Metal Oxychalcogenides β‐La2O2MSe2 (M: Mn, Fe).
Authors: McCabe Emma E. , Free David G. , Mendis Budhika G. , Higgins Joshua S. , Evans John S. O.
Published: January 2011

The new title compounds are prepared by reaction of La2O3, Se, and Mn or Fe powders in a molar ratio of 1:2:1 using Al powder as an oxygen getter (alumina crucibles, 1100 °C, 12 h).
ChemInform Abstract: Crystal Structure and Magnetic Properties of YbZn8.3‐9.2Ga2.7‐1.8 with BaHg11 Structure Type.
Authors: Verbovytskyy Yu. , Pereira L. C. J. , Goncalves A. P.
Published: January 2011

The title compound is prepared from the elements (evacuated quartz tube, 900 °C, 1 h) followed by annealing at 400 °C for 20 d.
ChemInform Abstract: SnxSy Compounds Growth by Controlled Sulfurization of SnO2.
Authors: Khelia C. , Boubaker K. , Amlouk M.
Published: January 2011

Thin layers of semiconducting SnxSy are prepared by sulfurization of SnO2:F films on glass substrates (660 °C, 2 h).
ChemInform Abstract: Low‐Temperature Synthesis of α‐ and β‐MoSi2 Powders Using Na.
Authors: Yamada Takahiro , Yamane Hisanori
Published: January 2011

The title compounds are prepared by heating 1:2 mixtures of Mo and Si powders with Na metal for 12 h.
ChemInform Abstract: Spectroscopic and Magnetic Properties of a Series of μ‐Cyano Bridged Bimetallic Compounds of the Type MII—NC—FeIII (M: Mn, Co, and Zn) Using the Building Block [FeIII(CN)5imidazole]2‐.
Authors: Tchouka Heloise , Meetsma Auke , Browne Wesley R.
Published: January 2011

The new compounds (VI), (VIII), (X), and (XII) are characterized by single crystal XRD, vibrational and electronic spectroscopy, and magnetic measurements.
ChemInform Abstract: Chiral Cobalt‐Catalyzed Enantioselective Aerobic Oxidation of α‐Hydroxy Esters.
Authors: Alamsetti Santosh Kumar , Sekar Govindasamy
Published: January 2011

The first report on a cobalt‐catalyst oxidative kinetic resolution of α‐hydroxy esters (I) is given.
ChemInform Abstract: Enantioselective Synthesis of β‐Hydroxy Ketones from Heterocyclic Aldehydes in Water Catalyzed by a Recyclable Organocatalyst Bearing an Ionic Liquid Moiety.
Authors: Siyutkin D. E. , Kucherenko A. S. , Zlotin S. G.
Published: January 2011

An efficient method for the dia‐ and enantioselective syntheses of chiral β‐hydroxy ketones is developed using the Aldol reaction of cyclic or heterocyclic ketones with heterocyclic aldehydes.
ChemInform Abstract: Highly Enantioselective Michael Addition of Malononitrile to Vinylogous Imine Intermediates Generated in situ from Arylsulfonyl Indoles.
Authors: Jing Linhai , Wei Jiangtao , Zhou Li , Huang Zhiyong , Li Zhengkai , Wu Di , Xiang Haifeng , Zhou Xiangge
Published: January 2011

The first highly enantioselective Michael addition of malononitrile to arylsulfonylindole‐derived vinylogous imine intermediates is presented.
ChemInform Abstract: Hg(OTf)2‐Catalyzed Cycloisomerization of Aryl‐ and Hetero‐Substituted 1,3‐Dienes.
Authors: Yamamoto Hirofumi , Shiomi Shinya , Odate Daiki , Sasaki Ikuo , Namba Kosuke , Imagawa Hiroshi , Nishizawa Mugio
Published: January 2011

The cycloisomerization takes place with complete (E)‐selectivity even when an E/Z‐mixture is used.
ChemInform Abstract: [Fe(F20TPP)Cl] Catalyzed Intramolecular C—N Bond Formation for Alkaloid Synthesis Using Aryl Azides as Nitrogen Source.
Authors: Liu Yungen , Wei Jinhu , Che Chi‐Ming
Published: January 2011

The title porphyrin is an effective catalyst for preparing indole, indoline, tetrahydroquinoline, dihydroquinazolinone, and quinazolinone alkaloids via intramolecular amination of sp2 and sp3 C—H bonds using aryl azides as nitrogen source.
ChemInform Abstract: Convenient Synthesis of Tetrahydro‐γ‐carbolines and Tetrahydroquinolines Through a Chemo‐ and Regioselectivity Switch by a Broensted Acid Catalyzed, One‐Pot, Multicomponent Reaction.
Authors: Cheng Hong‐Gang , Chen Cai‐Bao , Tan Fen , Chang Ning‐Jie , Chen Jia‐Rong , Xiao Wen‐Jing
Published: January 2011

N‐Protected 2‐vinylindoles react with aromatic aldehydes and anilines to give carboline products, whereas N‐unprotected 2‐vinylindoles afford under the same conditions tetrahydroquinoline products almost exclusively as cis‐diastereomers.
ChemInform Abstract: Synthesis of Three‐, Five‐, and Six‐Membered Heterocycles Derived from New β‐Amino‐α‐(trifluoromethyl) Alcohols.
Authors: Obijalska Emilia , Mloston Grzegorz , Linden Anthony , Heimgartner Heinz
Published: January 2011

Trifluoromethylated β‐amino alcohols (I) are convenient starting compounds for the synthesis of a variety of trifluoromethylated three‐, five‐ and six‐membered heterocycles.
ChemInform Abstract: [FeIII(F20‐tpp)Cl] Is an Effective Catalyst for Nitrene Transfer Reactions and Amination of Saturated Hydrocarbons with Sulfonyl and Aryl Azides as Nitrogen Source under Thermal and Microwave‐Assisted Conditions.
Authors: Liu Yungen , Che Chi‐Ming
Published: January 2011

The commercially available and air stable Fe‐complex is a useful catalyst for aziridination of alkenes, sulfimidation of both alkyl and aryl sulfides, direct allylic amidation/amination of α‐methylstyrenes, and amination of saturated C—H bonds including that of cycloalkanes with sulfonyl and aryl azides as the nitrogen source.
ChemInform Abstract: Water‐Soluble Palladium Nanoparticles: Click Synthesis and Applications as a Recyclable Catalyst in Suzuki Cross‐Couplings in Aqueous Media.
Authors: Mejias Nereida , Pleixats Roser , Shafir Alexandr , Medio‐Simon Mercedes , Asensio Gregorio
Published: January 2011

Polyethylene glycol‐tagged macrocycle (I) is prepared by a three‐fold copper‐catalyzed [3 + 2] cycloaddition reaction.
ChemInform Abstract: Mn(0)‐Mediated Chemoselective Reduction of Aldehydes. Application to the Synthesis of α‐Deuterioalcohols.
Authors: Jimenez Tania , Barea Elisa , Oltra J. Enrique , Cuerva Juan M. , Justicia Jose
Published: January 2011

Other functional groups such as ketones, esters, amides, nitriles, epoxides, and mesylates are not attacked.
ChemInform Abstract: Enantioselective Organocatalytic Michael Addition of Aldehydes to Trifluoroethylidene Malonates.
Authors: Wen Lele , Shen Qilong , Lu Long
Published: January 2011

A new protocol is developed which provides the Michael adducts with excellent enantioselectivity.
ChemInform Abstract: Gold(I) and Broensted Acid Catalyzed Intramolecular Rearrangements of Vinylidenecyclopropanes.
Authors: Lu Bei‐Li , Wei Yin , Shi Min
Published: January 2011

Vinylidenecyclopropanes (I) and (IV) undergo gold‐catalyzed rearrangement to give dienones (II) and (V), respectively.
ChemInform Abstract: Enantioselective 1,6‐Conjugate Addition to Cyclic Dienones Catalyzed by the Cu—DiPPAM Complex.
Authors: Wencel‐Delord Joanna , Alexakis Alexandre , Crevisy Christophe , Mauduit Marc
Published: January 2011

The transformation proceeds with complete regioselectivity and excellent enantioselectivity is obtained for 5‐and 6‐membered substrates.
ChemInform Abstract: Desulfonyloxyiodination of Arenesulfonic Acids with mCPBA and Molecular Iodine.
Authors: Suzuki Yuhsuke , Ishiwata Yoshihide , Moriyama Katsuhiko , Togo Hideo
Published: January 2011

Arene sulfonic acids are generally converted into the corresponding iodoarenes.
ChemInform Abstract: Sulfonato—Cu(salen) Complex Catalyzed N‐Arylation of Aliphatic Amines with Aryl Halides in Water.
Authors: Wu Zhiqing , Zhou Li , Jiang Zhaoqiong , Wu Di , Li Zhengkai , Zhou Xiangge
Published: January 2011

Aryl bromides, iodides, and electron‐deficient chlorides are applicable, as well as α‐ and β‐amino acids.
ChemInform Abstract: One‐Pot Preparation of Imines from Nitroarenes by a Tandem Process with an Ir—Pd Heterodimetallic Catalyst.
Authors: Zanardi Alessandro , Mata Jose A. , Peris Eduardo
Published: January 2011

A general and efficient method for the preparation of imines by the reaction of alcohols and nitroarenes is reported.
ChemInform Abstract: Ring Opening of a Trisubstituted Aziridine with Amines: Regio‐ and Stereoselective Formation of Substituted 1,2‐Diamines.
Authors: Kelley Brandon T. , Joullie Madeleine M.
Published: January 2011

The ring opening occurs exclusively at the more hindered and electronically activated C‐2 carbon strictly with inversion of configuration.
ChemInform Abstract: Rhenium‐Catalyzed Regioselective Synthesis of Phenol Derivatives from 1,3‐Diesters and Terminal Alkynes.
Authors: Kuninobu Yoichiro , Iwanaga Takashi , Nishi Mitsumi , Takai Kazuhiko
Published: January 2011

Reaction of malonates lacking a substituent at the active methylene moiety with terminal aromatic alkynes gives salicylates (III) regioselectively.
ChemInform Abstract: A Green and Efficient Oxidation of Benzylic Alcohols Using H2O2 Catalyzed by Montmorillonite‐K10 Supported MnCl2.
Authors: Najafi Gholam Reza
Published: January 2011

Primary and secondary benzylic alcohols are oxidized to the corresponding carbonyl compounds in good yields with the help of the title catalyst, which is found to be reusable at least three times without a significant decrease in its activity.
ChemInform Abstract: Palladium‐Catalyzed Suzuki—Miyaura Cross‐Coupling Reactions of Enantiomerically Enriched Potassium β‐Trifluoroboratoamides with Various Aryl‐ and Hetaryl Chlorides.
Authors: Molander Gary A. , Shin Inji , Jean‐Gerard Ludivine
Published: January 2011

The starting materials bearing pseudoephedrine as chiral auxiliary are air‐ and moisture‐stable reagents.
ChemInform Abstract: Tandem Three‐Component Reaction of Aldehyde, Alkyl Acrylate, and Amide Using Ethyl Diphenylphosphine as Organocatalyst.
Authors: Syu Siang‐en , Wang De‐Wei , Chen Pei‐yi , Hung Yi‐Ting , Jhang Yi‐Wun , Kao Tzu‐Ting , Lee Yu‐Ting , Lin Wenwei
Published: January 2011

The process is chemoselective and affords highly functionalized products in moderate to good yields, however, with only low diastereoselectivity.
ChemInform Abstract: A Facile and Efficient One‐Pot Synthesis of Nitriles from Aldehydes Using Hypervalent Iodine(III) Reagents in Aqueous Ammonium Acetate.
Authors: Zhu Chenjie , Ji Lei , Wei Yunyang
Published: January 2011

Exclusion of air or moisture is not necessary and, in most cases, simply passing the mixtures through a plug of silica affords pure products.
ChemInform Abstract: A Flow Microreactor System Enables Organolithium Reactions Without Protecting Alkoxycarbonyl Groups.
Authors: Nagaki Aiichiro , Kim Heejin , Moriwaki Yuya , Matsuo Chika , Yoshida Jun‐ichi
Published: January 2011

The generation of o‐, m‐ and p‐lithiated benzoic acid esters is studied using a microflow reactor system.
ChemInform Abstract: TiCl4‐Promoted Direct N‐Acylation of Sulfonamide with Carboxylic Ester.
Authors: Fu Shaomin , Lian Xiaoyan , Ma Tongmei , Chen Wenhau , Zheng Meifang , Zeng Wei
Published: January 2011

In most cases, the process is highly successful to give the desired products in moderate to excellent yields.
ChemInform Abstract: Planar Chiral Flavinium Salts — Prospective Catalysts for Enantioselective Sulfoxidation Reactions.
Authors: Jurok Radek , Cibulka Radek , Dvorakova Hana , Hampl Frantisek , Hodacova Jana
Published: January 2011

The asymmetric H2O2 oxidation of aryl alkyl sulfides is smoothly catalyzed by an axially chiral flavinium salt to give enantioenriched sulfoxides in up to 54% optical purity.
ChemInform Abstract: [Pd(Cl)2{P(NC5H10) (C6H11)2}2] — A Highly Effective and Extremely Versatile Palladium‐Based Negishi Catalyst That Efficiently and Reliably Operates at Low Catalyst Loadings.
Authors: Bolliger Jeanne L. , Frech Christian M.
Published: January 2011

A new, highly efficient and versatile catalyst for Negishi cross coupling of (het)aryl bromides with (het)arylzinc reagents is presented.
ChemInform Abstract: Zinc(II)‐Catalyzed Mannich‐Type Reactions of Hydrazones with Difluoroenoxysilane and Its Application in the Synthesis of Optically Active 2,2‐Difluoro‐3‐oxo‐benzohydrazide.
Authors: Yuan Zhiliang , Wei Yin , Shi Min
Published: January 2011

The novel catalytic reaction system is applicable to reactions of hydrazones (I) with difluoroenoxysilane (II) providing Mannich adducts (III) in moderate to good yields under mild conditions.
ChemInform Abstract: Palladium‐Catalyzed Oxidative Cross‐Coupling Reaction of Arylboronic Acids with Diazoesters for Stereoselective Synthesis of (E)‐α,β‐Diarylacrylates.
Authors: Tsoi Yuk‐Tai , Zhou Zhongyuan , Chan Albert S. C. , Yu Wing‐Yiu
Published: January 2011

Optimized conditions using molecular oxygen as the sole reoxidant are elaborated.
ChemInform Abstract: Palladium‐Catalyzed Cross‐Coupling of Cyclopropylmagnesium Bromide with Aryl Bromides Mediated by Zinc Halide Additives.
Authors: Shu Chutian , Sidhu Kanwar , Zhang Li , Wang Xiao‐jun , Krishnamurthy Dhileepkumar , Senanayake Chris H.
Published: January 2011

The title reaction provides an improved method to prepare various cyclopropyl arenes.
ChemInform Abstract: Highly Enantioselective Organocatalytic Michael Addition of 2‐Hydroxy‐1,4‐naphthoquinone to β,γ‐Unsaturated α‐Oxo Esters.
Authors: Wang Yi‐Feng , Zhang Wei , Luo Shu‐Ping , Zhang Guang‐Cun , Xia Ai‐Bao , Xu Xiang‐Sheng , Xu Dan‐Qian
Published: January 2011

The title reaction is catalyzed by a readily available cinchona‐derived squaramide at low loading.
ChemInform Abstract: Niobium‐Catalyzed Activation of CF3 Group on Alkene: Synthesis of Substituted Indenes.
Authors: Fuchibe Kohei , Atobe Kohei , Fujita Yukari , Mori Keiji , Akiyama Takahiko
Published: January 2011

An unexpected isomerization is observed for 3,3,3‐trifluoropropenes (III) and (VI), respectively, regardless of their geometry.
ChemInform Abstract: Synthesis of New Polyconjugated Compounds Based on 9,10‐Diphenylphenanthrene.
Authors: Ol'khovik V. K. , Vasilevskii V. A. , Galinovskii N. A.
Published: January 2011

New phenanthrene derivatives (I) show strong luminescence in the solid state and in solution.
ChemInform Abstract: Organocatalytic Synthesis of Spiro Compounds via a Cascade Michael—Michael‐Aldol Reaction.
Authors: Companyo Xavier , Zea Alex , Alba Andrea‐Nekane R. , Mazzanti Andrea , Moyano Albert , Rios Ramon
Published: January 2011

The title reaction affords spirooxindole derivatives in good yields and with high diastereo‐ and enantioselectivity.
ChemInform Abstract: Charge‐Transfer Effect on Chiral Phosphoric Acid Catalyzed Asymmetric Baeyer—Villiger Oxidation of 3‐Substituted Cyclobutanones Using 30% Aqueous H2O2 as the Oxidant.
Authors: Xu Senmiao , Wang Zheng , Zhang Xumu , Ding Kuiling
Published: January 2011

The intermolecular charge‐transfer effect is employed as a modulating approach to affect the enantioselectivity in asymmetric catalysis by using the chiral phosphoric acid catalyzed asymmetric Baeyer—Villiger oxidation of aryl‐substituted cyclobutanones (I) as the reaction prototype.
ChemInform Abstract: One‐Pot Desulfurative—Fluorination—Bromination. Synthesis of 2,5‐Dibromo‐3‐(1,1‐difluoroalkyl)thiophenes
Authors: Turkman Nashaat , An Lingling , Pomerantz Martin
Published: January 2011

as starting material for conductive polymers
ChemInform Abstract: A Rapid Three‐Component MgI2‐Mediated Synthesis of 3,3‐Pyrrolidinyl‐Spirooxindoles.
Authors: Helan Victoria , Mills Allie , Drewry David , Grant Daniel
Published: January 2011

A wide range of biologically interesting title compounds is available.
ChemInform Abstract: Reactions of Substituted Oxazoles and Thiazoles with Acid Chlorides: Carbon—Carbon Bond Formation Through Cyclic Ketene Acetals.
Authors: Chatterjee Sabornie , Ye Guozhong , Song Yingquan , Barker Bobby Lloyd , Pittman Charles U. Jr.
Published: January 2011

The reaction of 2‐alkylated thiazoles and oxazoles with aryl chlorides is investigated under different conditions.
ChemInform Abstract: Novel Syntheses of Variably Substituted Pyrrolo[2,3‐d]thiazoles.
Authors: Koolman Hannes , Heinrich Timo , Reggelin Michael
Published: January 2011

o‐Aminoalkynylthiazoles, prepared from substrate (I) under conditions A), are converted to the desired heterocyclic skeleton via microwave‐assisted 5‐endo dig cyclization.
ChemInform Abstract: Ultrasonic‐Assisted One‐Pot Synthesis of Pyrazolo[1,2‐a][1,2,4]triazole‐1,3‐diones.
Authors: Azarifar Davood , Yami Razieh Nejat
Published: January 2011

A facile one‐pot three‐component synthesis of title compounds (IV) (20 example) is presented.
ChemInform Abstract: Asymmetric Organocatalytic Michael Addition of α,β‐Unsaturated Ketone with 1,2,4‐Triazole.
Authors: Zhou Yufeng , Li Xin , Li Wenjun , Wu Chunlin , Liang Xinmiao , Ye Jinxing
Published: January 2011

The process is applicable to aryl and cyclic ketones and thus allows the access to various optically active nitrogen heterocycles.
ChemInform Abstract: Transition‐Metal‐Free Catalytic Synthesis of 1,5‐Diaryl‐1,2,3‐triazoles.
Authors: Kwok Sen W. , Fotsing Joseph R. , Fraser Rebecca J. , Rodionov Valentin O. , Fokin Valery V.
Published: January 2011

The reaction of alkyl acetylenes fails.
ChemInform Abstract: Preparation and Evaluation of Antibacterial Activity of Some New 1,2,4‐Triazole Derivatives.
Authors: Arafa W. A. A.
Published: January 2011

Cyclization reactions of both the triazolecarbohydrazine (I) and thiosemicarbazide (III) under various conditions afford novel biheterocyclic systems involving triazole, thiadiazole and thiazolidinone rings.
ChemInform Abstract: Synthesis of 1‐Hydroxybenzotriazoles Angularly Annulated by Furazan or Furoxan Rings.
Authors: Samsonov V. A. , Sal'nikov G. E. , Genayev A. M.
Published: January 2011

Facile routes for the synthesis of triazolobenzoxadiazole (IX) and related N‐oxides [cf.
ChemInform Abstract: The Reaction of 3,4‐Dihydro‐2H‐pyran with Oxalyl Chloride: Formation and Crystal Structure Analysis of an Unexpected Bicyclic Product.
Authors: Schmidt Bernd , Werner Frank , Kelling Alexandra , Schilde Uwe
Published: January 2011

The reaction of (I) with oxalyl chloride and selected nucleophilic reagents leads to the unexpected bicyclic product (IV) and/or dihydropyran carboxylic acid derivatives, e.g. (V) and (VIII).
ChemInform Abstract: Palladium‐Catalyzed [4 + 2] Cycloaddition of o‐(Silylmethyl)benzyl Esters with Ketones: An Equivalent to Oxo‐Diels—Alder Reaction of o‐Xylylenes.
Authors: Ueno Satoshi , Ohtsubo Masakazu , Kuwano Ryoichi
Published: January 2011

The procedure affords various benzopyran derivatives where the regioselectivity depends on the structure of both substrates (reaction mechanism).
ChemInform Abstract: Synthesis, Complexation, and Biological Activity Studies of 4‐Aminomethyl‐7,8‐dihydroxy Coumarines (V) and Their Crown Ether Derivatives (VII).
Authors: Guemues Arzu , Karadeniz Seref , Ugras Halil Ibrahim , Bulut Mustafa , Cakir Uemit , Goeren Ahmet Ceyhan
Published: January 2011

Some of the synthesized compounds show remarkable antimicrobial and antioxidant activity.
ChemInform Abstract: Synthesis of Pyrano[3,4‐c]chromene Skeleton via CuI‐Mediated Domino Knoevenagel Hetero‐Diels—Alder Reaction.
Authors: Mollazadeh Marjan , Khoshkholgh Malihe Javan , Balalaie Saeed , Rominger Frank , Bijanzadeh Hamid Reza
Published: January 2011

A new strategy starting from simple and inexpensive materials is used for the preparation of the title compounds, e.g. (III) and (V).
ChemInform Abstract: [2 + 2] Photochemical Cycloaddition/Ring Opening of 6‐Alkenyl‐2,3‐dihydro‐4‐pyridones.
Authors: Sahn James J. , Comins Daniel L.
Published: January 2011

Irradiation of the dihydropyridines (I) provides the fused cyclobutanes (II).
ChemInform Abstract: A New Strategy for the Synthesis of Poly‐Substituted 3‐H, 3‐Fluoro, or 3‐Trifluoromethyl Pyridines via the Tandem C—F Bond Cleavage Protocol.
Authors: Chen Zixian , Zhu Jiangtao , Xie Haibo , Li Shan , Wu Yongming , Gong Yuefa
Published: January 2011

Whereas pyridine formation is highly successful with amines bearing an aromatic substituent, no cyclization takes place with butylamine.
ChemInform Abstract: Bifunctional Thiourea‐Promoted Cascade Aza‐Michael—Henry—Dehydration Reactions: Asymmetric Preparation of 3‐Nitro‐1,2‐dihydroquinolines.
Authors: Liu Xiaoqian , Lu Yixin
Published: January 2011

A cascade aza‐Michael‐Henry‐dehydration reaction leads to a one‐step preparation of 3‐nitro‐1,2‐dihydroquinolines in high yields and up to 90% ee.
ChemInform Abstract: Three‐Step Synthesis of 2,4‐Diaryl‐5,6,7,8‐tetrahydroquinoline Derivatives.
Authors: Gezegen Hayreddin , Dingil Alparslan , Ceylan Mustafa
Published: January 2011

The title compounds are prepared in high yields under mild reaction conditions in three steps starting from easily available acetophenone and benzaldehyde derivatives.
ChemInform Abstract: An Efficient Synthesis of 6‐Nitro‐ and 6‐Amino‐3H‐imidazo[4,5‐b]pyridines by Cyclocondensation of 1‐Substituted 1H‐Imidazol‐5‐amines with 3‐Nitro‐4H‐chromen‐4‐one.
Authors: Ostrovskyi Dmytro , Iaroshenko Viktor O. , Petrosyan Andranik , Dudkin Sergii , Ali Iftikhar , Villinger Alexander , Tolmachev Andrei , Langer Peter
Published: January 2011

1‐H‐imidazole‐5‐amines, generated in situ from formimidate (II) and primary amines, react with chromenone (I) to produce imidazopyridines (IV) which represent potential adenosine deaminase inhibitors.
ChemInform Abstract: One‐Pot Synthesis of Spiro[diindeno[1,2‐b:2′,1′‐e]pyridine‐11,3′‐indoline]‐triones.
Authors: Ghahremanzadeh Ramin , Fereshtehnejad Fatemeh , Bazgir Ayoob
Published: January 2011

An efficient and simple multi‐component synthesis with easy work‐up is developed.
ChemInform Abstract: New Pyrrolo[2,1‐a]phthalazine Derivatives by One‐Pot Three‐Component Synthesis.
Authors: Dumitrascu Florea , Caproiu Miron Teodor , Georgescu Florentina , Draghici Bogdan , Popa Macel Mirel , Georgescu Emilian
Published: January 2011

The reactions are carried out in 1,2‐epoxybutane which acts as reaction medium and HBr scavenger.
ChemInform Abstract: Synthesis and Structural Study of N‐Methyl‐2‐methylthiopyrimidine Derivatives from Trihalomethylated Enones.
Authors: Zanatta Nilo , Madruga Claudia C. , Marisco Patricia C. , da Rosa Luciana S. , da Silva Fabio M. , Bonacorso Helio G. , Martins Marcos A. P.
Published: January 2011

Reactions of trihalomethylated enones with dimethylisothiourea sulfate furnish chemoselectivity 2‐methylthiotetrahydropyrimidine or ‐dihydropyrimidine derivatives depending on the reaction conditions and electronic effects of the substituents on the enones.
ChemInform Abstract: Strontium Chloride‐Catalyzed One‐Pot Synthesis of 4(3H)‐Quinazolinones under Solvent‐Free Conditions.
Authors: Wang Min , Song Zhi Guo , Zhang Ting Ting
Published: January 2011

The reaction is found to generate the target compounds in moderate to high yield in relatively short time if arylamines are used as starting products.
ChemInform Abstract: Microwave‐Assisted Broensted Acidic Ionic Liquid‐Promoted One‐Pot Synthesis of Heterobicyclic Dihydropyrimidinones by a Three‐Component Coupling of Cyclopentanone, Aldehydes, and Urea.
Authors: Rahman Matiur , Majee Adinath , Hajra Alakananda
Published: January 2011

The catalyst can be reused at least 6 times without decrease in catalytic activity.
ChemInform Abstract: Design, Synthesis, and Characterization of Some Novel Pyrazolo[1,5‐a]pyrimidines as Potent Antimicrobial Agents.
Authors: Dawane Bhaskar S. , Konda Shankaraiah G. , Zangade Sainath B.
Published: January 2011

New compounds (Vb)—(Vd) show potent antimicrobial activities.
ChemInform Abstract: First Synthesis of 2‐Phosphonylated Quinoxaline 1,4‐Dioxides: An Extension to the Beirut Reaction.
Authors: Dahbi Samir , Methnani Ebtissem , Bisseret Philippe
Published: January 2011

Good yields are only obtained if the initial THF suspension is transformed to into a pasty film by slow evaporation of ca. 90& of the initial solvent volume.
ChemInform Abstract: Synthesis and Characterization of Novel Fluorescent Compounds Derived from 1,4‐Diethyl‐1,2,3,4‐tetrahydro‐6‐nitroquinoxaline.
Authors: Satam Vijay S. , Rajule Rajkumar N. , Jagtap Amit R. , Bendre Samir R. , Pati Hari N. , Kanetkar Vinod R.
Published: January 2011

A benzimidazole‐ and a benzothiazole‐substituted derivative of tetrahydropyridoquinoxaline are synthesized, which exhibit strong fluorescence in a variety of solvents and good thermal stability up to 250 °C.
ChemInform Abstract: Synthesis of Naphtho[2,3‐b]‐ and Naphtho[1,2‐b]‐Fused Thieno[2,3‐d][1]benzoxepins and Thieno[2,3‐d][1]benzothiepins.
Authors: Ozimec Landek Ivana , Pesic Dijana , Trojko Rudolf , Devcic Bogdanovic Maja , Mercep Mladen , Mesic Milan
Published: January 2011

Four novel classes of structurally related fused hetero‐pentacyclic compounds such as the [1,2]‐fused naphthothienobenzoxepins (XIIIa) and (XIIIb), and the [1,2]‐fused naphthothienobenzothiepine (XIIIc) are synthesized.
ChemInform Abstract: Ni(0)‐Catalyzed 1,4‐Selective Diboration of Conjugated Dienes.
Authors: Ely Robert J. , Morken James P.
Published: January 2011

In the presence of Ni(cod)2/PCy3, a wide range of 1,3‐dienes including internal and sterically hindered ones efficiently undergo 1,4‐diboration.
ChemInform Abstract: Rapid Synthesis of an Electron‐Deficient t‐BuPHOX Ligand: Cross‐Coupling of Aryl Bromides with Secondary Phosphine Oxides.
Authors: McDougal Nolan T. , Streuff Jan , Mukherjee Herschel , Virgil Scott C. , Stoltz Brian M.
Published: January 2011

Copper‐catalyzed coupling of aryl bromides, containing a chiral oxazoline moiety, with secondary phosphine oxides provides tertiary phosphine oxides which can be reduced to PHOX‐type ligands as demonstrated for the example (S)‐IIIa.
ChemInform Abstract: Catalytic Asymmetric Synthesis of Quaternary α‐Hydroxy Trifluoromethyl Phosphonate via Chiral Aluminum(III) Catalyzed Hydrophosphonylation of Trifluoromethyl Ketones.
Authors: Zhou Xin , Zhang Qi , Hui Yonghai , Chen Weiliang , Jiang Jun , Lin Lili , Liu Xiaohua , Feng Xiaoming
Published: January 2011

The reaction proceeds under mild conditions and avoids completely the phospha‐Brook rearrangement and other side reactions.
ChemInform Abstract: Preparation and Characterization of Novel 4‐Bromo‐3,4‐dimethyl‐1‐phenyl‐2‐phospholene 1‐Oxide and the Analogous Phosphorus Heterocycles or Phospha Sugars.
Authors: Yamashita Mitsuji , et al. et al.
Published: January 2011

Some new 4‐bromo‐2‐phospholene 1‐oxides (IV) are synthesized by allylic radical bromination of 2‐phospholene oxides (III).
ChemInform Abstract: Development of Photostable Near‐Infrared Cyanine Dyes
Authors: Samanta Animesh , Vendrell Marc , Das Rajkumar , Chang Young‐Tae
Published: January 2011

rational design of an amine tricarbocyanine structure with improved photostability and its combinatorial derivatization to render CyNA‐414 (I) as a near‐infrared fluorescent dye with stronger emission intensity and higher photostability than NIR standard IndoCyanine Green
ChemInform Abstract: Scaparvin A, a Novel Caged cis‐Clerodane with an Unprecedented C‐6/C‐11 Bond, and Related Diterpenoids from the Liverwort Scapania parva.
Authors: Guo Dong‐Xiao , Zhu Rong‐Xiu , Wang Xiao‐Ning , Wang Li‐Ning , Wang Shu‐Qi , Lin Zhao‐Min , Lou Hong‐Xiang
Published: January 2011

Scaparvin A (I) is isolated together with the analogues scaparvin B (IIa), C (IIb), D (IIc) and E (III).
ChemInform Abstract: Formal Total Synthesis of (.+‐.)‐Hirsutic Acid C Using the Tandem Rh(I)‐Catalyzed [(5 + 2) + 1] Cycloaddition/Aldol Reaction.
Authors: Yuan Changxia , Jiao Lei , Yu Zhi‐Xiang
Published: January 2011

The known precursor (VI) of title acid (VII) is prepared.
ChemInform Abstract: Enantiopure 1,2‐Bis(tert‐butylmethylphosphino)benzene as a Highly Efficient Ligand in Rhodium‐Catalyzed Asymmetric Hydrogenation.
Authors: Tamura Ken , Sugiya Masashi , Yoshida Kazuhiro , Yanagisawa Akira , Imamoto Tsuneo
Published: January 2011

The new biphosphine ligand provides excellent enantioselectivities up to 99.9%.
ChemInform Abstract: Chemical Investigation of Drug‐Like Compounds from the Australian Tree, Neolitsea dealbata.
Authors: Tran Tron D. , Pham Ngoc B. , Fechner Gregory , Quinn Ronald J.
Published: January 2011

New aporphine alkaloid, (6aR)‐normecambroline (I), is isolated, together with eight known alkaloids, from the bark of Neolitsea dealbata.
ChemInform Abstract: Synoxazolidinones A and B: Novel Bioactive Alkaloids from the Ascidian Synoicum pulmonaria.
Authors: Tadesse Margey , Stroem Morten B. , Svenson Johan , Jaspars Marcel , Milne Bruce F. , Toerfoss Veronika , Andersen Jeanette H. , Hansen Espen , Stensvaeg Klara , Haug Tor
Published: January 2011

Preliminary studies reveals antibacterial and antifungal activity for both components.
ChemInform Abstract: Synthesis of Novel Acyclic Nucleoside Analogues with anti‐Retroviral Activity.
Authors: Paju A. , Paeri M. , Selyutina A. , Zusinaite E. , Merits A. , Pehk T. , Siirde K. , Mueuerisepp A.‐M. , Kailas T. , Lopp M.
Published: January 2011

Novel acyclic thymine nucleoside analogues (VI) are synthesized starting from enantiopure γ‐lactone acids (I).
ChemInform Abstract: A Facile Synthesis of Novel Acyclo‐C‐Nucleoside Analogues from L‐Rhamnose via Variants of Bohlmann—Rahtz Reaction.
Authors: Kantevari Srinivas , Putapatri Siddamal Reddy
Published: January 2011

Various target compounds are readily available following the title reaction.
ChemInform Abstract: Design, Synthesis, and Anticancer Activities of Novel Perfluoroalkyltriazole‐Appended 2′‐Deoxyuridines.
Authors: Park Sun Min , Yang Heeju , Park Song‐Kyu , Kim Hwan Mook , Kim Byeang Hyean
Published: January 2011

A series of new perfluoroalkyltriazole‐appended 2‐deoxyuridines (V) (5 examples) is synthesized using the Sharpless click reaction.
ChemInform Abstract: An Elimination Approach to the Synthesis of (+)‐Scorodonin.
Authors: Zhang Yan , Wu Yikang
Published: January 2011

This elimination approach leads to the synthesis of the chiral allene‐alkyne assembly (XII) of the natural antibiotic scorodonin.
ChemInform Abstract: Asymmetric Total Synthesis of Glycinoeclepin A (VIII): Generation of a Novel Bridgehead Anion Species.
Authors: Shiina Yasuhiro , Tomata Yoshihide , Miyashita Masaaki , Tanino Keiji
Published: January 2011

The preparation of the title compound, a hatchstimulating agent of the soybean cyst nematode, proceeds via construction of the CD‐segment (IV) and introduction of the A‐ ring moiety [cf.
ChemInform Abstract: First Total Synthesis of Ocimarin (III)
Authors: Yang Jin Hui , Li Yun Feng , Ji Cong Bin , Jiang Shi Zhi , Liu Wan Yi
Published: January 2011

employing a CeCl3‐catalyzed Pechmann condensation of resorcinol (II) and β‐keto ester (I) under solvent‐free conditions as key step
ChemInform Abstract: Rare Earth—Mg—Ni‐Based Hydrogen Storage Alloys as Negative Electrode Materials for Ni/MH Batteries.
Authors: Liu Yongfeng , Cao Yanhui , Huang Li , Gao Mingxia , Pan Hongge
Published: January 2011

Review: 131 refs.
ChemInform Abstract: Materials Challenges Toward Proton‐Conducting Oxide Fuel Cells: A Critical Review
Authors: Fabbri Emiliana , Pergolesi Daniele , Traversa Enrico
Published: January 2011

Review: 170 refs.
ChemInform Abstract: Oxide‐ion and Proton Conducting Electrolyte Materials for Clean Energy Applications: Structural and Mechanistic Features
Authors: Malavasi Lorenzo , Fisher Craig A. J. , Islam M. Saiful
Published: January 2011

Review: 217 refs.
ChemInform Abstract: Alternative Catalytic Materials: Carbides, Nitrides, Phosphides and Amorphous Boron Alloys
Authors: Alexander Anne‐Marie , Hargreaves Justin S. J.
Published: January 2011

Review: 195 refs.
ChemInform Abstract: Nanostructured Materials for Thermoelectric Applications
Authors: Bux Sabah K. , Fleurial Jean‐Pierre , Kaner Richard B.
Published: January 2011

Review: 131 refs.
ChemInform Abstract: Laser Ablation and Thin Film Deposition
Authors: Schneider Christof W. , Lippert Thomas
Published: January 2011

Review: 99 refs.
ChemInform Abstract: MgO Tunnel Barriers in Magnetic Nanostructures and Devices
Authors: Heindl R. , Pufall M. R. , Rippard W. H.
Published: January 2011

Review: 18 refs.
ChemInform Abstract: Dipyrrin‐Based Homo‐ and Hetero‐Metallic Infinite Architectures
Authors: Baudron Stephane A.
Published: January 2011

Review: 94 refs.
ChemInform Abstract: Isolable Vinylgold Intermediates — First Access to Phantoms of Homogeneous Gold Catalysis
Authors: Hashmi A. Stephen K.
Published: January 2011

Review: 25 refs.
ChemInform Abstract: Unprecedented Triphosphinine Iron Interactions: Intramolecular Electron Transfer, Reactivity Round a Corner, and a Low‐Activated Ring Element Exchange Reaction
Authors: Eggers Karin , Heinemann Frank W. , Hennemann Matthias , Clark Timothy , Binger Paul , Zenneck Ulrich
Published: January 2011

Review: 47 refs.
ChemInform Abstract: Recent Methodologies Toward the Synthesis of Valdecoxib: A Potential 3,4‐Diarylisoxazolyl COX‐II Inhibitor
Authors: Dadiboyena Sureshbabu , Nefzi Adel
Published: January 2011

Review: 90 refs.
ChemInform Abstract: Reactions of Carbon Acids and 1,3‐Dipoles in the Presence of Ionic Liquids
Authors: Zlotin S. G. , Makhova N. N.
Published: January 2011

Review: 333 refs.
ChemInform Abstract: Elegant and Helpful: Biomimetic Synthetic Strategies
Authors: Harschneck Tobias , Kirsch Stefan F.
Published: January 2011

Review: for natural products; 11 refs.
ChemInform Abstract: Transition‐Metal‐Catalyzed Additions of Carbonyl Functionalities to Alkynes
Authors: Fujihara Tetsuaki , Iwai Tomohiro , Terao Jun , Tsuji Yasushi
Published: January 2011

Review: about 50 refs.
ChemInform Abstract: Chiral Hexacoordinated Phosphates: From Pioneering Studies to Modern Uses in Stereochemistry
Authors: Lacour Jerome
Published: January 2011

Review: 118 refs.
ChemInform Abstract: Lewis Acidic Metal Catalyzed Organic Transformations by Designed Multicomponent Structures and Assemblies
Authors: Ali Afsar , Singh Amit P. , Gupta Rajeev
Published: January 2011

Review: 37 refs.
ChemInform Abstract: Free Radical Thiol—Ene and Thiol—Yne Coupling as Selective Ligation Tools for Glycoconjugation
Authors: Dondoni Alessandro
Published: January 2011

Review: 21 refs.
ChemInform Abstract: Enantio‐ and Diastereoselective Rh(II)‐Catalyzed 1,3‐Dipolar Cycloadditions of Carbonyl Ylides and Their Recent Applications in Complex Molecule Synthesis
Authors: France Stefan , Phun Lien H.
Published: January 2011

Review: 68 refs.
ChemInform Abstract: Efficient Cyclization Routes to Substituted Heterocyclic Compounds Mediated by Transition‐Metal Catalysts
Authors: Cossy Janine
Published: January 2011

Review: 63 refs.
ChemInform Abstract: The Potential of Ellagic Acid as a Possible Antimalarial Drug Candidate
Authors: Fotie Jean
Published: January 2011

Review: 106 refs.
ChemInform Abstract: Recent Advances in Asymmetric Oxidative Coupling of 2‐Naphthol and Its Derivatives
Authors: Wang Hui
Published: January 2011

Review: 83 refs.
ChemInform Abstract: Linking Rings Without Templates
Authors: Beves Jonathan E. , Leigh David A.
Published: January 2011

Review: 13 refs.
ChemInform Abstract: Recent Progress on Enyne Metathesis: Its Application to Syntheses of Natural Products and Related Compounds
Authors: Mori Miwako
Published: January 2011

Review: 152 refs.
ChemInform Abstract: Asymmetric Autocatalysis. Automultiplication of Chiral Molecules
Authors: Soai Kenso , Kawasaki Tsuneomi
Published: January 2011

Review: 98 refs.
ChemInform Abstract: Aliphatic Nucleophilic Radiofluorination
Authors: Roeda Dirk , Dolle Frederic
Published: January 2011

Review: 171 refs.
ChemInform Abstract: “Greening Up” Cross‐Coupling Chemistry
Authors: Lipshutz Bruce H. , Abela Alexander R. , Boskovic Zarko V. , Nishikata Takashi , Duplais Christophe , Krasovskiy Arkady
Published: January 2011

Review: 36 refs.
ChemInform Abstract: Discovery of Environmentally Benign Catalytic Reactions of Alcohols Catalyzed by Pyridine‐Based Pincer Ru Complexes, Based on Metal‐Ligand Cooperation
Authors: Milstein David
Published: January 2011

Review: 59 refs.
ChemInform Abstract: Recent Progress in a Chiral Multinucleating System Utilizing Tartaric Acid Esters
Authors: Ukaji Yutaka , Inomata Katsuhiko
Published: January 2011

Review: 125 refs.
ChemInform Abstract: Functional Phthalocyanines: Synthesis, Nanostructuration, and Electro‐Optical Applications
Authors: de la Torre Gema , Bottari Giovanni , Hahn Uwe , Torres Tomas
Published: January 2011

Review: 286 refs.
ChemInform Abstract: Kinetic Studies of Reactions of Organosilylenes: What Have They Taught Us?
Authors: Becerra Rosa , Walsh Robin
Published: January 2011

Review: 109 refs.
ChemInform Abstract: Regeneration of Perivascular Nerve and Role of Angiotensin Receptors
Authors: Hobara Narumi , Goda Mitsuhiro , Yoshida Namika , Hashikawa Naoya , Kawasaki Hiromu
Published: January 2011

Review: 6 refs.
ChemInform Abstract: Application of Mercury‐Resistant Genes in Bioremediation of Mercurials in Environments
Authors: Pan‐Hou Hidemitsu
Published: January 2011

Review: 77 refs.
ChemInform Abstract: Semiconductor‐Mediated Photodegradation of Pollutants under Visible‐Light Irradiation
Authors: Chen Chuncheng , Ma Wanhong , Zhao Jincai
Published: January 2011

Review: 63 refs.
ChemInform Abstract: Chromatic Polydiacetylene with Novel Sensitivity
Authors: Sun Xuemei , Chen Tao , Huang Sanqing , Li Li , Peng Huisheng
Published: January 2011

Review: 53 refs.
ChemInform Abstract: Ionic Liquids: Solutions for Electrospray IoniZation Mass Spectrometry
Authors: Dyson Paul J. , Henderson Matthew A. , McIndoe J. Scott
Published: January 2011

Review: 37 refs.
ChemInform Abstract: Time‐Resolved Structural Studies of Protein Reaction Dynamics: A Smorgasbord of X‐Ray Approaches
Authors: Westenhoff Sebastian , Nazarenko Elena , Malmerberg Erik , Davidsson Jan , Katona Gergely , Neutze Richard
Published: January 2011

Review: 143 refs.
Preparation of Copper Chromite by Vaccum Freezing Drying Method and Its Catalytic Activity for Sulfuric Acid Decomposition
Authors: Su Tao , Zhang Ping , Wang Laijun , Chen Songzhe
Published: January 2011

Iodine sulfur (IS) process is one of the most promising routes for massive and CO2‐free hydrogen production. Among the three reactions IS process composed, decomposition of sulfuric acid is the most energy intensive step and has to be conducted in the presence of catalyst. In this work, copper chromite (CuCr2O4) was prepared, characterized, and used as the catalyst for sulfuric acid decomposition reaction. The co‐precipitation preparation method of CuCr2O4 which featured in vacuum freezing drying (VFD), was applied, and the main factors which influence the structure of CuCr2O4 such as pH values of the co‐precipitation solution and calcination temperature were investigated. Results showed that pH value affected the size of copper chromite granule, when pH was between 7 and 8, the size of prepared CuCr2O4 was in nanometer scale. Calcination temperature influenced the purity of the crystal. The samples were characterized by XRD, TEM and BET. The catalytic activity of CuCr2O4 prepared by VFD was evaluated and compared with CuCr2O4 prepared by usual co‐precipitation method and Pt/Al2O3. Results showed that the activity of CuCr2O4 was close to that of Pt catalyst, but apparently higher than that of CuCr2O4 prepared by usual method. In addition, it presents good stability in the 70 h test. Therefore, it was promising to be used in the sulfuric acid decomposition step of IS process.
Theoretical Studies on the Halogen Bond between Propargyl Radical and Dihalogen Molecules
Authors: Zeng Yanli , Li Xiaoyan , Zhang Xueying , Meng Lingpeng , Zheng Shijun
Published: January 2011

MP2/aug‐cc‐pVDZ calculations are carried out on the geometries, vibrational frequencies, interaction energies and topological properties for the π‐type halogen‐bonded complexes between propargyl radical and dihalogen molecules ClF, BrF and BrCl. There are two kinds of geometries: complex (a) involves the interaction between the X (X=Cl, Br) atom and the midpoint of C(1) –C(2) bond, complex (b) involves the interaction between the X atom and C(3) atom. The lengths of the halogen bond, the frequencies of the halogen bond, the elongation extent of the X–Y (XY=ClF, BrF, BrCl) bond, topological parameters at the BCPs of the halogen bond and X–Y bond are all well consistent with the interaction energies. The interaction of complex (a) is stronger than that of complex (b); the interaction of propargyl···BrF is stronger than that of propargyl···ClF and propargyl···BrCl. For the complexes (a) and (b), the charge transfer is observed from propargyl radical to XY, the atomic energy, the dipolar polarization, and the volume of the halogen atom X decrease upon complex formation.
Multi‐spectroscopic Study on the Interaction between CdTe Quantum Dots and Bovine Serum Albumin
Authors: Fan Jingzhou , Zhou Juan , Sun Tingquan , Lü Shiyan , Tang Jinyan , Lü Jianquan
Published: January 2011

The interaction between CdTe quantum dots (QDs) and bovine serum albumin (BSA) was systematically investigated by fluorescence, UV‐vis absorption and circular dichroism (CD) spectroscopy under physiological conditions. The experimental results showed that the fluorescence of BSA could be quenched by CdTe QDs with a static quenching mechanism, indicating that CdTe QDs could react with BSA. The quenching constants according to the modified Stern‐Volmer equation were obtained as 1.710×106, 1.291×106 and 1.010×106 L·mol−1 at 298, 304, and 310 K, respectively. ΔH, ΔS and ΔG for CdTe QDs‐BSA system were calculated to be −33.68 kJ·mol−1, 6.254 J·mol−1·K−1 and −35.54 kJ·mol−1 (298 K), respectively, showing that electrostatic interaction in the system played a major role. According to F?rster theory, the distance between Trp‐214 in BSA and CdTe QDs was given as 2.18 nm. The UV‐vis, synchronous fluorescence and CD spectra confirmed further that the conformations of BSA after addition of CdTe QDs have been changed.
Theoretical Studies on Energetic Property and Stability of Pyrazine and Pyridine Derivatives
Authors: Fan Xiaowei , Gu Chenggang , Chen Gong , Ju Xuehai
Published: January 2011

Density functional calculations at the B3LYP level with 6‐311G** and aug‐cc‐pVDZ basis sets were performed to predict the heats of formation (HOFs) for two pyrazine derivatives and eight pyridine derivatives. In the isodesmic reactions designed for the computation of heats of formation (HOFs), pyrazine and pyridine were chosen as reference compounds. TheN‐oxidations for the ring nitrogen of pyrazine and pyridine derivatives decrease the HOF values whenN‐oxide oxygen is neighboring with amino groups, but increase when it neighbors with nitro groups. Thermal stability was evaluated via bond dissociation energies (BDE) at the UB3LYP/6‐311G** level. As a whole, the homolysis of C–NO2bonds is the main step for bond dissociation of the title compounds. The BDE values of title compounds are influenced by intramolecular hydrogen bonds. The hydrogen bond effects associated with the length of the H···O bonds were analyzed by the electron density at the critical points and natural bond orbital.
Highly Efficient InBr3 Catalyzed Michael Addition of Indoles to α,β‐Unsaturated Esters
Authors: Liu Ping , Chen Wei , Ren Kai , Wang Lei
Published: January 2011

A highly efficient synthetic strategy toward Michael addition of indoles to α,β‐unsaturated esters has been developed using Lewis acid InBr3 as catalyst. The reactions generated 3‐substituted indoles in high yields with excellent regio‐selectivity in the presence of catalytic amount of InBr3 under mild reaction conditions. The method is simple, efficient and practical.
Synthesis and Anticancer Properties of Rare Earth Substituted Tungstophosphoric Polyoxometalate Containing 5‐Fluorouracil
Authors: Liu Xia , Wang Shuaishuai , Feng Changgen
Published: January 2011

Three novel rare earth substituted polyoxometalates containing 5‐fluorouracil, K10C4H4FN2O2Pr(PW11O39)2·24H2O, K10C4H4FN2O2Nd(PW11O39)2·12H2O and K10C4H4FN2O2Sm(PW11O39)2·12.5H2O were synthesized and structurally characterized by elemental analysis, IR spectra, X‐ray powder diffraction and 183W NMR. The results indicate that the compounds have Keggin structure of heteropolyanion and ring structure of 5‐fluorouracil. The cytotoxicity test of the compounds in human renal embryonic cell HEK293 and the activity inhibiting human cervical carcinoma cell Hela were studied by the methyl thiazolyl tetrazolium method with 5‐fluorouracil for the positive control group. The toxicity of the compounds are lower than that of 5‐fluorouracil. K10C4H4FN2O2Pr(PW11O39)2·24H2O has no apparent toxicity in vitro and can inhibit Hela cells in vitro with significant difference compared with 5‐Fu.
Highly Efficient Palladacycle/Dihydroimidazolium Chloride System for the Suzuki‐Miyaura Cross‐Coupling of Aryl Halides (I, Br, Cl) with Arylboronic Acids
Authors: Wang Haiming , Wang Jinping , Qiu Wenwei , Yang Fan , Liu Xiaofeng , Tang Jie
Published: January 2011

A combination of a tertiary amine‐based palladacycle and an N‐heterocyclic carbene ligand precursor (1, N,N‐bis‐mesityl‐4,5‐dihydroimidazolium chloride) has been applied to catalyze the Suzuki‐Miyaura cross‐coupling of aryl halides with arylboronic acids. The substrate scope is general: a variety of electron rich and deficient aryl halides (I, Br, Cl) and arylboronic acids were found to undergo the cross‐coupling reaction in good to excellent yields at low catalyst loading of 0.01–1 mol%.