bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Media Penetasan Berbeda Terhadap Fekunditas dan Daya Tetas Telur Ikan Nila
Authors: Adipu Yulianty , Ngabito Meriyanti , Olii Mohammad Yasin Omsini Putra , Pigome Jarik
Published: August 2024

Pemenuhan kebutuhan akan ikan perlu adanya penguasaan teknik pembenihan, salah satu kendala yang dihadapi dalam kegiatan pembenihan adalah penguasaan teknologi penetasan. Sistem inkubasi merupakan salah satu teknik penetasan yang dapat diterapkan, teknik ini diharapkan dapat meningkatkan fekunditas dan daya tetas telur ikan nila. Adapun tujuan dari penelitian ini adalah untuk mengetahui nilai fekunditas dan daya tetas telur ikan nila yang menggunakan media penetasan yang berbeda. Metode penelitian dilakukan secara eksperimental dengan menggunakan Rancangan Acak Lengkap dengan tiga perlakuan yang terdiri dari Perlakuan A. Sistem Inkubasi, B. sistem Air Tenang dan C. Kontrol, terdiri dari tiga kali ulangan. Hasil penelitian menunjukkan nilai fekunditas tertinggi pada perlakuan A.10.700 butir dan terendah perlakuan B. 4.200 butir, daya tetasa telur tertinggi pada perlakuan A. 67% dan perlakuan B sejumlah 20% paling rendah. Kualitas air selama penelitian seluruh perlakuan terdiri dari suhu 23 -310C, pH 6,0 – 7,5 dan kandungan oksigen 3,02 – 5,91 sehingga disimpulkan nilai fekunditas dan daya tetas telur ikan nila yang menggunakan media penetasan yang berbeda menujukkan keberhasilan yang cukup baik pada sistem inkubasi.
Towards Sustainable Food Packaging: A Study of Konjac Glucomannan and κ-Carrageenan Synergy
Authors: Lenfant Baptiste , Haumont Raphaël
Published: August 2024

This study investigates the synergistic effect of konjac glucomannan (KGM) and k-carrageenan (k-CG) in developing sustainable food films. KGM and k-CG were dissolved at various ratios (20:80 to 80:20 KGM/k-CG ratio), casted, and dried. The resulting films were characterized by their mechanical properties, water vapor permeability, and water solubility. The results showed that the combination of KGM and k-CG resulted in a synergistic effect on the water solubility of the films, which decreased significantly compared to the individual components. The tensile strength increased significantly while the elongation at break decreased the more k-CG was added. An optimal point was found at a 60:40 ratio. The water vapor permeability of the films was also significantly higher compared to PVC film or k-CG film, indicating a lesser barrier property. X-ray diffraction investigation shows that films are amorphous (whereas pure kappa is crystallized), and no co-crystallization was observed based on the different KG/ k-CG ratios. Overall, this study demonstrates the potential of combining KGM and k-CG to develop sustainable food films with enhanced properties. Using natural polysaccharides in the food industry can contribute to developing eco-friendly and sustainable packaging solutions.
ОСВІТНЬО-ІНФОРМАЦІЙНЕ СЕРЕДОВИЩЕ ПІДГОТОВКИ МАЙБУТНІХ ФАХІВЦІВ ІЗ ТУРИЗМУ
Authors: Безкоровайна Лариса Вікторівна , Венгерська Наталя Сергіївна , Андрюкайтене Регіна Михайлівна , Воронкова Валентина Григорівна
Published: August 2024

Актуальність дослідження: якісна туристична освіта сьогодні є одним із найважливіших питань для туристичної індустрії, оскільки світовими тенденціями нині є спрямування на сталий розвиток туризму, що має ураховувати ефективність професійної підготовки компетентних, конкурентоспроможних фахівців, що володіють, зокрема, інформаційними технологіями. Предметом дослідження є процес визначення особливостей розроблення освітньо-інформаційного середовища професійної підготовки майбутніх фахівців із туризму та з’ясування характерних рис його впровадження в закладах вищої освіти. Мета дослідження: з’ясувати особливості розроблення освітньо-інформаційного середовища підготовки майбутніх фахівців із туризму та характерні риси впровадження його в освітній процес закладів вищої освіти. Методологія дослідження: аналіз, контент-аналіз, гіпотетико-дедуктивний метод, метод системного аналізу; метод вивчення об’єкта у його цілісності, у єдиному і взаємному зв’язку його частин; методи класифікації, порівняння, узагальнення, моделювання; метод проєктування. Результати дослідження: встановлено доцільність та необхідність розроблення освітньо-інформаційного середовища підготовки майбутніх фахівців із туризму, з’ясовано його особливості та характерні риси впровадження в освітній процес закладів вищої освіти. Практичне значення: отримано результати, котрі полягають у систематизації логістики розроблення освітньо-інформаційного середовища підготовки майбутніх фахівців із туризму, а також особливостей його впровадження в освітньому процесі закладів вищої освіти. Висновки: виокремлено характерні риси розроблення освітньо-інформаційного середовища підготовки майбутніх фахівців із туризму, його взаємозв’язки всередині та зовні; з’ясовано особливості його впровадження в освітній процес закладів вищої освіти; визначено вплив освітньо-інформаційного середовища на якість підготовки фахівців із туризму. Перспектива подальших досліджень полягає у вивченні інших шляхів формування професійних компетентностей, якими має володіти майбутній фахівець туристичного напряму для успішного працевлаштування та ефективної професійної діяльності в сучасних умовах світового туристичного ринку.
Вплив співвідношення між азотом та калієм у системах удобрення пшениці озимої на її продуктивність та якість зерна
Authors: Шевчук М.Й. , Лукащук Л.Я. , Злотенко О.Ю.
Published: August 2024

Мета. Встановити оптимальне співвідношення між азотом та калієм у системах удобрення пшениці озимої та його вплив на продуктивність і якість зерна. Методи. В основу досліджень покладені польові досліди з використанням методів: візуального – для визначення фенологічних фаз росту і розвитку культури; підрахункового – для визначення параметрів структури врожаю і урожайності культури; хімічного – для визначення вмісту елементів живлення в ґрунті; математико-статистичного – для оцінки достовірності результатів досліджень. Результати. Застосування мінеральних добрив за вирощування пшениці ози- мої сприяло продуктивному кущінню рослин, кількість продуктивних стебел на удобрених варіантах перевищувала контроль (без добрив) на 37–97 шт./м2 (7,7–20,1%), що забезпечило зростання врожайності зерна. В середньому за роки досліджень внесення калійних добрив забезпечило отримання додаткового зерна 0,49–0,84 т/га (8,6–14,8%) на азотно-фос- форному фоні N120Р70 і 0,38–0,75 т/га (5,8–11,1%) – на фоні N180Р70. При цьому найбільш високі показники продуктивності отримано за внесення N180Р70К120, де врожайність становила 7,31 т/га. Удобрення озимої пшениці сприяло покращенню якості зерна. За трьохрічними даними вміст білка в зерні збільшився на удобрених варіантах від 11,5 до 13,4% за показника на контролі – 9,4%, вміст сирої клейковини – від 20,5 до 25,2% (контроль – 13,0%). Висновки. За вирощування озимої пшениці в умовах Західного Лісостепу на чорноземі типовому неглибокому слабко гумусованому легкосуглинковому з низьким вмістом азоту, високим – фосфору і середнім калію встановлено, що найвищу врожайність зерна в досліді (7,31 т/га) забезпечило внесення N180Р70К120, приріст урожайності до контролю (без добрив) становив 3,15 т/га, або 75,7%. Найбільш прийнятним співвідношенням азоту і калію в удобренні озимої пшениці є 1: 0,66–0,75, за якого отримані максимальні прирости врожайності зерна в досліді порівняно з фонами N120Р70 – фон 1 та N180Р70 – фон 2: за внесення N120Р70К90 – 0,84 т/га (14,8%), за внесення N180Р70К120 – відповідно 0,75 т/га (11,1%). Застосування мінеральних добрив сприяло формуванню продовольчого зерна пшениці озимої відповідного ІІ-ІІІ класу якості згідно з ДСТУ: 3768-2010.
PERBANKAN SYARIAH DI NEGARA INGGRIS
Authors: Baihaki Ahmad
Published: August 2024

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Determinan Minat Masyarakat Desa Airgegas Kebupaten Bangka Selatan Menabung di Bank Syariah
Authors: Findriyani Ella , Wulpiah Wulpiah , Nurdin Muhammad
Published: August 2024

The development of Islamic banking is still not widely known by the majority of the public. This is due to the insufficient outreach efforts made by Islamic banking institutions. Consequently, the public lacks understanding about Islamic banking products, and there is a need to capture the attention of the residents of Airgegas village or motivate them by addressing the factors that influence their decision to choose Islamic banking services, which include knowledge and motivation. This research aims to identify the determining factors of interest in saving, specifically knowledge and motivation, among the residents of Airgegas Village in South Bangka Regency in saving at Islamic banks. This research employs a quantitative approach. The population in this study consists of 4,786 individuals, with the sample selection technique being simple random sampling. The sample size was determined using the Slovin formula, resulting in 98 respondents. Data processing was conducted using SPSS version 26. The results of this study indicate that the knowledge variable (X1) influences the interest of the residents of Airgegas Village in saving at Islamic banks (Y) with a t-value of 9.699 > t-table value of 1.985. Furthermore, the motivation variable (X2) influences the interest of the residents of Airgegas Village in saving at Islamic banks (Y) with a t-value of 2.592 > t-table value of 1.985. Simultaneously, the knowledge (X1) and motivation (X2) variables have a positive influence, with an F-value of 109.714 > F-table value of 3.09, thus H0 is rejected and Ha is accepted. Therefore, both variables together have a positive and significant effect on the interest of the residents of Airgegas Village in saving at Islamic banks.
Features of the Heterofunctional Polycondensation of Phenyldialkoxysilanes by the Pierce–Rubinstein Reaction
Authors:   A.N. Nesmeyanov Institute of Organolement Compounds, Russian Academy of Sciences, ul. Vavilova 28, str. 1, Moscow, 119334 Russia, Hasiak Y. K. ,   ula State Lev Tolstoy Pedagogical University, pr. Lenina 125, korp. 4, Tula, Tula Oblast, 300026 Russia, Frank I. V. ,   A.N. Nesmeyanov Institute of Organolement Compounds, Russian Academy of Sciences, ul. Vavilova 28, str. 1, Moscow, 119334 Russia,   Moscow Institute of Physics and Technology (National Research University), Institutskiy per. 9, Dolgoprudny, Moscow Oblast, 141700 Russia, Tiulkin A. A. ,   A.N. Nesmeyanov Institute of Organolement Compounds, Russian Academy of Sciences, ul. Vavilova 28, str. 1, Moscow, 119334 Russia, Shishkanov M. V. ,   A.N. Nesmeyanov Institute of Organolement Compounds, Russian Academy of Sciences, ul. Vavilova 28, str. 1, Moscow, 119334 Russia, Temnikov M. N. ,   A.N. Nesmeyanov Institute of Organolement Compounds, Russian Academy of Sciences, ul. Vavilova 28, str. 1, Moscow, 119334 Russia,   ula State Lev Tolstoy Pedagogical University, pr. Lenina 125, korp. 4, Tula, Tula Oblast, 300026 Russia, Anisimov A. A. ,   A.N. Nesmeyanov Institute of Organolement Compounds, Russian Academy of Sciences, ul. Vavilova 28, str. 1, Moscow, 119334 Russia,   ula State Lev Tolstoy Pedagogical University, pr. Lenina 125, korp. 4, Tula, Tula Oblast, 300026 Russia,   Moscow Institute of Physics and Technology (National Research University), Institutskiy per. 9, Dolgoprudny, Moscow Oblast, 141700 Russia
Published: August 2024

This work is devoted to the investigation of the interaction features of phenyldialkoxysilanes (methoxy, ethoxy and n-propoxy, AB2-type monomers) in the Pierce–Rubinstein reaction under different conditions. The effect of the monomer introduction rate, monomer concentration, and temperature on the structure and molecular weight characteristics of the products was evaluated. Using 1H and 29Si NMR spectroscopy as well as MALDI-TOF mass spectrometry, it was shown that an increase in the volume of the organic substituent (on passing from Me to Ph) at the silicon atom leads to the products of cyclic and linear structures.
EXPLORING THE EFFECTIVENESS OF Pseudomonas aeruginosa ISOLATES FOR BIOREMEDIATION OF CRUDE OIL-CONTAMINATED SOILS USING SOYBEAN HULL AS A BIOSTIMULANT: A FOCUS ON ETPH AND PAHs
Authors: Ajao Abdullahi , Jimoh-Hamza Oluwabukola Kudirat
Published: August 2024

The Speciated EPA-16 Polyaromatic Hydrocarbons (PAHs) in crude oil pose significant environmental and health risks due to their harmful properties. This study focused on indigenous bacteria capable of degrading Extractable Total Petroleum Hydrocarbons (ETPHs) and PAHs through a Nutrient-Amended Bioaugmentation Strategy (N-ABS). Crude oil-degrading bacteria were isolated from contaminated soil in Alakiri Community, Rivers State, Nigeria, leading to the identification of four Pseudomonas aeruginosa isolates (KUD1-4) via 16S rRNA gene sequencing. Bioremediation treatments, using both bacterial isolates and Soybean hull as a biostimulant, showed that P. aeruginosa KUD2 achieved the highest removal efficiencies of 96.59% for ETPHs and 80.00% for PAHs. This study underscores the potential of P. aeruginosa KUD2 and Soybean hull in remediating crude oil-contaminated soils.
Hubungan Pola Asuh Orang Tua Dengan Pembentukan Akhlak Siswa SMPN 34 Makassar
Authors: Elmi Kadir  , Hasibuddin  , Shamad Ishaq
Published: August 2024

Tujuan penelitian ini adalah mengetahui peran antara hubungan pola asuh orang tua terhadap akhlak siswa dan pengaruh pola asuh terhadap akhlak siswa di SMP Negeri 34 Makassar. Penelitian ini menggunakan jenis penelitian kualitatif, dengan menggunakan pendekatan pedagogik, subjek penelitiannya adalah guru, orang tua, dan siswa SMP Negeri 34 Makassar. Instrumen penelitian menggunakan wawancara, observasi, dan dokumentasi. Hasil penelitian menunjukkan bahwa pola asuh berpengaruh positif dan memiliki hubungan dengan pembentukan akhlak. Kenyataan dilapangan membuktikan bahwa setiap keluarga tidak hanya terpaku pada satu jenis pola asuh, karena orang tua menyadari bahwa pola asuh harus disesuaikan dengan konteks kebutuhan dan kemampuan anak, untuk itu terkadang pola asuh yang berhasil. dilaksanakan oleh keluarga belum tentu dapat diterapkan. baik oleh keluarga lain. Karena setiap keluarga memiliki nilai-nilai tersendiri. Pengaruh pola asuh (demokratis, pasif, otoriter, dan lalai) berpengaruh terhadap pembentukan akhlak siswa SMP Negeri 34 Makassar. Hal ini diperkuat dengan hasil uji T (parsial) nilai signifikansi = 0,000, korelasi parsial pola asuh terhadap pembentukan moral anak di SMP Negeri 34 Makassar sebesar 0,621 atau 62,1%. Dari hasil perhitungan tersebut ternyata nilai t hitung lebih besar dari t tabel dimana nilai signifikansi 0,000 Lebih kecil dari 0,01. Sehingga hipotesis yang berbunyi ada hubungan dan pengaruh yang signifikan antara pola asuh terhadap pembentukan akhlak anak di SMP Negeri 34 Makassar
Integrasi Project Based Learning dalam Modul PAI: Meningkatkan Keterlibatan Siswa di SMK
Authors: Nurlaelah  , Deriwanto  , Hartini  , Nurjannah
Published: August 2024

This study aims to develop a Project Based Learning (PjBL) based Islamic Education (PAI) module in Vocational High Schools (SMK) in Gowa, South Sulawesi, focusing on enhancing student engagement and learning outcomes. The identified problem is the low student engagement in PAI learning caused by conventional teaching methods. The method used in this research is a literature review, which examines various sources related to PjBL and PAI. The results indicate that the application of PjBL can significantly improve students' learning outcomes, as well as enhance their social skills and character. Several previous studies have shown an increase in learning outcomes and student motivation after the implementation of PjBL. Thus, the development of a PAI module based on PjBL is expected to provide an innovative solution to improve the quality of learning in SMK. The conclusion of this research is that PjBL is an effective approach in PAI learning, which can enhance student engagement and learning outcomes, as well as contribute positively to character education among SMK students.
PENGARUH KOMUNIKASI KELUARGA BROKEN HOME PADA TINGKAT DEPRESI ANAK REMAJA DI KOTA MAKASSAR
Authors: Apriliana Amnia , Zelfia Zelfia , Rahmawati Sitti
Published: August 2024

The purpose of the study was to find out the Effect of Broken Home Family Communication on the Level of Adolescent Depression in Makassar City. The research method used is Quantitative Research, using primary data and secondary data by providing questionnaires / statement sheets to 30 respondents who are willing to be respondents. The results showed that Broken Home Family Communication had a positive and significant effect on the Level of Adolescent Depression in Makassar City. Based on the results of partial test (t-test) hypothesis X obtained that Family Communication has a significant and positive influence on depression levels in broken home families. Testing the effect of communication variables on depression levels can be known by looking at the t calculated value for family communication of 6,697 and t table of 2.048, with significance of 0.000. The t value is greater than the t table and the significance value below 0.05 indicates the effect of the Communication variable on the Level of Child Depression
MAKNA KARYA UMBUL DONGA DALAM PELEPASAN WISUDAWAN FAKULTAS SENI PERTUNJUKAN ISI SURAKARTA PERIODE II 15 OKTOBER 2019
Authors: Wardhani Chrysnanda Kusuma
Published: August 2024

This research is aimed to describe the form and content of Umbul Donga on the Second Period of Graduation Ceremony of The Performing Arts Faculty in the Indonesian Institute of the Arts, Surakarta which was held on October, 15th 2019. This research was done by employing qualitative methods with descriptive narrative analysis and holistic criticism of dance performance by Sutopo. There were several research steps done to accurately collect the data. Data was collected through various sources of references, interviews, and audio-visual records. Sources of references are employed to understand the concept, notion, and background that are correlated with the essence of this research. Furthermore, those are complemented by employing interviews with people who were involved in the Graduation Ceremony of The Performing Arts Faculty at The Indonesian Institute of Arts that was held on October, 15th 2019. The form analysis was done by using Speech Act Theory by Kreidler. Umbul Donga is constructed of two elements (verbal and nonverbal elements). Those are supported by the Performing Arts Theory by Maryono. The Performing Arts Theory was employed to explain non-verbal components which consist of themes, movements, dancers, expressions, floor patterns, makeups, and music.  It was found that based on the verbal and nonverbal analysis, work conception, and audience feedback, Umbul Donga on the Second Period of Graduation Ceremony of The Performing Arts Faculty in the Indonesian Institute of the Arts, Surakarta which was held on October, 15th 2019 can be interpreted as a medium of pray forgiveness, gratitude, and guidance.
Territory of Student Community Spaces Based on Fixed Elements, Semi-Fixed Elements, and Activity Patterns
Authors: Tamimi Shabrina , Munawarah Panggabean Siti , Rachma Marcillia Syam
Published: August 2024

Student community spaces are essential facilities provided by universities to support various extracurricular activities. However, these spaces often fail to fully accommodate the diverse needs and activities of students, leading to a process of adaptation where users modify the space by adding both physical and non-physical elements. This study, utilizing behavior mapping and questionnaires, aims to analyze how students use and adapt these community spaces, focusing on the territorial adjustments made through physical elements and user activities. The findings reveal that most space adaptations involve semifixed elements, particularly in areas where informal activities take place. In contrast, formal activities tend to be conducted in indoor spaces where the physical elements are predominantly fixed. These insights highlight the necessity for more flexible and adaptable design strategies in student community spaces to better meet the needs of their users.
Improving Literacy and Minahasan Cultural Values through Folklore Reading to Paniki Bawah’s Children Residents
Authors: Kobis Dewi Christa , Sigarlaki Stephani , Pamantung Rina
Published: August 2024

The project of public service implemented for this study aimed to improve literacy and Minahasan cultural values through folklore reading. The participants of this public service were 20 poverty-stricken children who lived in Paniki Bawah sub-district located in Manado, North Sulawesi. Before the public service project was implemented, the majority of them were only in the Word Level of literacy level and had zero knowledge about Minahasa folklore. However, after the public service implementation, most of the participants reached the highest level of literacy level, which is called Story 2 Level where they could rewrite their stories by paraphrasing them into their own words but did not eliminate any content of the folklores. This public service project was considered a successful movement and able to improve the participants’ literacy as well as their Minahasan cultural values.
Validity and Reliability Testing of the Indonesian Version of the Exercise and Menstruation Questionnaire (EMQ-I) Assessing the Phenomenon of Menstruation in Sports
Authors: Widiawati Prisca , Putra Ramadhan Muhammad , Purwadi Dinda Arisetya , Zulqarnain Mohd Nasir Muhammad , Juzaily Mohd Nasiruddin Nasnoor
Published: August 2024

Menstruation is a natural biological process that occurs in women and is controlled by hormonal fluctuations. This study can support the achievements of female athletes, especially in Indonesia, where communication and perceptions related to menstruation have not been included in the criteria for creating training programs. This study aimed to examine the validity and reliability of the Indonesian version of the Exercise and Menstruation Questionnaire (EMQ-I) measuring the phenomenon of menstruation in sport. The population for this study was female athletes in Malang, Indonesia, aged 18-35 years, who participated in various sports with a total of 57 athletes. This study uses a methodological approach that combines qualitative and quantitative components. The qualitative stage involves translators and experts in the field of menstruation and sports to validate the content. The quantitative stage tests the validity and reliability using statistical analysis with results ranging from 0.628 to 0.909 and reliability ranging from 0.856 to 0.927. The results of the data analysis showed that 88.5% of the question items were valid to be announced to respondents. The total items to be announced were 33 items and had been tested for validity and reliability by experts and in-depth data analysis. This research is expected to be a literature material and input for coaches in Indonesia to create training programs that are suitable for women and improve sports achievements in Indonesia.
Acute Effects of High-intensity Circuit Training Using Body Weight on Body Composition Indices in Sedentary Collegiate Females
Authors: Ozlen Putra Asyran Naim Khaizal , Hussain Raja Nurul Jannat Raja , Shari Maisarah , Ahmad Mohamad Firdaus , Wan Pa Wan Ahmad Munsif , Nadzalan Ali Md , Md Radzi Noor Azila Azreen , Kasim Nurul Ain Abu , Mohamed Muhamad Noor , Al Ghazaly Muhammad Dzikry Abdullah
Published: August 2024

High-intensity circuit training (HICT) has become increasingly popular for enhancing health and fitness. However, limited research exists on the effects of high-intensity circuit training using body weight (HICTBW) on body composition in sedentary young adults. This study aimed to explore the impact of a 4-week HICTBW program on body composition in sedentary collegiate females. A randomized controlled trial design was employed. Twenty sedentary collegiate females were randomly assigned to either a training group (n=10), which participated in a 4-week HICTBW program, or a control group (n=10), which did not engage in any training. Body composition was assessed using bioelectrical impedance analysis (r = 0.642 to 0.78), measuring body fat percentage, fat mass, muscle mass, waist-to-hip ratio, and body mass index (BMI). Repeated measure ANOVA was used to compare between and within groups. Although no significant differences in body composition variables were observed between pre- and post-training (p>0.05), slight positive changes were noted in all measured parameters. The lack of significant findings may be attributed to the short duration and frequency of the intervention. Future studies with extended training periods are recommended to better understand the potential impact of HICTBW on body composition in sedentary collegiate females. This research highlights the need for more comprehensive studies to validate the effectiveness of HICTBW in improving body composition among this population.
Coexistence of Transverse Myelitis and Acute Disseminated Encephalomyelitis; a rare case
Authors: Nas Kırdar Nurten , Aslan Özlem
Published: August 2024

Background: Transverse myelitis (TM) is a disease in which motor, sensory and autonomic dysfunction develops as a result of localized inflammation of the spinal cord. Acute disseminated encephalomyelitis (ADEM) is a disease of sudden onset and variable clinical course characterized by demyilination of the central nervous system. Although ADEM and TM are separate entities clinically and radiologically, they have many similarities in terms of treatment and rehabilitation approach.
Case report: A 14-year-old female patient applied to the emergency service with the complaints of lowback pain, weakness in the legs, stumbling and falling. In addition to the paraplegia clinic, there were sensory defect, urinary retention and loss of control of the anal sphincter. ADEM and TM were diagnosed by considering the differential diagnoses due to demyelinating plaques seen in cranial and spinal MRI examinations. High-dose methyl prednisolone and IVIG were given for treatment. After this treatment, dorsiflexion muscle strength of both ankles improved to 2/5. After starting the rehabilitation program, it was observed that there was a gradual improvement in muscle strength. At the end of the 3rd month, the patient was able to walk independently without support, urinate spontaneously and easily do her daily work.
Conclusion: Despite the poor prognostic factors, we achieved very good results with an effective medical treatment and rehabilitation program in our case with the association of ADEM and TM, which we encountered as a rare condition. We hope that our case will contribute to the literature on the importance of rehabilitation.
Tradisi Karia pada Masyarakat di Desa Masalili Kecamatan Kontunaga Kabupaten Muna
Authors: Wahyuni Ela sri , Baka Wa Kuasa , Saputri Shinta Arjunita
Published: August 2024

Research on Karia tradition aims to describe the process of implementing Karia tradition in Masalili Village, Kontunaga District, Muna Regency and analyze the meaning of materials and tools used in the process of implementing Karia tradition in Masalili Village, kontunaga District, Muna Regency. Research methods in data collection are conducted by observation techniques (observation), interviews and documentation. The informant technique uses purposive techniques. Data is analyzed by data collection techniques, data reduction, data presentation, and conclusion drawing (verification). Research methods in data collection are carried out by observation techniques (observation), interviews and documentation. The informant technique uses purposive techniques. Data is analyzed by data collection techniques, data reduction, data presentation, and conclusion drawing (verification). This research uses the theory of semiotics Charles Sanders Peirce posits that the theory of semiotics is based on logic, because logic studies how people reason besides it does signs that allow us to think relate to others and give meaning to what is displayed by the universe. The results of this study show that in the process of implementing the Karia tradition has 2 stages, namely (1) the preparation stage consisting of Karia participants and deliberation. (2) The implementation stages consisting of the recitation of the Bharasanji prayer (recitation of Sholawat), Kafoluku, Kaghombo, Kafosampu, Katandano Wite, Linda Dance, and finally Kaghorono Bhansa. The importance of materials and tools that contain meaning in the Karia procession, namely the collection of Kaghombo water, is interpreted as the purity of Karia participants, which means that all their ugliness has disappeared according to the pouring of Kaghombo water bathed by Pamantoto. Then the use of coconut mayang and areca nut (bhansa) is interpreted as that the Karia participants have grown up and. For the tools used in the accompaniment of the Karia procession, namely gongs and drums called rambi wuna which has a meaning as a sign of notification in the form of an invitation to the community to attend the Karia ceremony so that the atmosphere is always crowded.
Implementasi Sistem Informasi Monitoring Sarana Proteksi Kebakaran di PT. X
Authors: Nuriyah Intan Shinta , Kramanandita Ridzky
Published: August 2024

PT X merupakan perusahaan manufaktur bergerak dibidang otomotif yang mengutamakan kualitas dan keselamatan dalam proses produksinya, terutama dalam menghadapi risiko kebakaran yang sebagian besar proses produksinya banyak menggunakan bahan kimia berbahaya yang mudah terbakar. Departemen yang bertanggung jawab dalam menangani hal tersebut adalah Departemen Environment Health and Safety (EHS). Untuk penanggulangan kebakaran EHS memiliki sarana proteksi kebakaran yaitu APAR & Hydrant. EHS melakukan pengecekan dan monitoring APAR & Hydrant guna optimalisasi pemeliharaan APAR & Hydrant agar sarana proteksi kebakaran di PT X selalu siap digunakan. Namun, pada proses pengecekan dan monitoring APAR & Hydrant sulit dilakukan pencarian data dan tracing kondisi APAR & Hydrant dikarena kompleksitas perusahaan yang besar, sehingga APAR & Hydrant tersebar diberbagai lokasi dan proses pencarian data serta melacak kondisi APAR & Hydrant menjadi sulit. Oleh karena itu, penelitian ini bertujuan untuk membuat sistem informasi APAR & Hydrant dengan QR Code untuk mempermudah pengecekan, pencarian dan penyajian data. Metode pengembangan sistem yang digunakan dalam penelitian ini adalah RAD (Rapid Application Development), serta perancangan sistem dengan menggunakan tools UML (Unified Modeling Language). Tahap pengkodean dilakukan menggunakan bahasa pemrograman PHP 7.1 dengan framework Laravel 5.3. Kemudian hasil dari penelitian ini berupa Sistem Informasi Monitoring Sarana Proteksi Kebakaran berbasis website yang memudahkan pengecekan serta pemantauan APAR & Hydrant di seluruh lokasi perusahaan melalui QR Code dan fitur reminder.
Pemberdayaan Lingkungan Berbasis Ecopesantren di Pondok Pesantren Darul Huffaz Lampung
Authors: Sari Nurhalina , Natalina Natalina , Saputra Firman Dwi , Ardika Muhammad Fajar , Rahmadhan Arif
Published: August 2024

The Darul Huffaz Islamic Boarding School has a problem with piles of rubbish, where up to now the rubbish has only been collected, transported, and thrown to the Pesawaran TPA. Eco-Islamic boarding school-based education is an activity to make Islamic boarding schools environmentally friendly through real action. The aim of this community service (PKM) is to carry out eco-Islamic boarding school-based environmental empowerment at the Darul Huffaz Islamic Boarding School. The PKM partner is the Darul Huufaz Islamic Boarding School with a target of 32 female student volunteers, teachers, and employees. The activities were carried out for five months, from July to November 2023. Environmental empowerment activities carried out were the creation of waste banks in Islamic boarding schools, the use of organic waste into compost, and inorganic waste into eco-bricks. This community service activity is carried out in stages, namely the situational analysis of partner conditions, socialization, implementation, monitoring, evaluation, and expansion. Mentoring and training activities resulted in an increase in the knowledge of residents at the Darul Huffaz Islamic Boarding School by 10%, the formation of waste bank peer educators, and a waste management program under the guidance of the Darul Huffaz Islamic Boarding School OSIS through compost and eco-bricks making activities. It is hoped that this PKM activity can become a learning method for developing eco-Islamic boarding school-based education at the Darul Huffaz Islamic Boarding Schools.
Classifying musical reading expertise by eye-movement analysis using machine learning
Authors: Drai-Zerbib Véronique , Ansart Manon , Grenot Clément , Poulin-Charronnat Bénédicte , Perra Joris , Baccino Thierry
Published: August 2024

Music reading is the key to literacy for musicians in the Western music tradition. This high-level activity requires an efficient extraction of the visual information from the score to the current needs of the execution. Differences in eye movements between expert and non-expert musicians during music reading have been shown. The present study goes further, using a machine learning approach to classify musicians according to their level of expertise in analyzing their eye movements and performance during sight-reading. We used a support vector machine (SVM) technique to (a) investigate whether the underlying expertise in musical reading could be reliably inferred from eye movements, performance, and subjective measures collected across five levels of expertise and (b) determine the best predictors for classifying expertise from 24 visual measures (e.g., the number of progressive fixations, the number of regressive fixations, pupil size, first-pass fixations, and second-pass fixations), 10 performance measures (e.g., eye–hand span, velocity, latency, play duration, tempo, and false notes), and 4 subjective measures (perceived complexity and cognitive skills). Eye movements from 68 pianists at five different levels of music expertise (according to their level in the conservatory of music—from first cycle to professional) were co-registered with their piano performance via a Musical Instrument Digital Interface, while they sight-read classical and contemporary music scores. Results revealed relevant classifications based on the SVM analysis. The model optimally classified the lower levels of expertise (1 and 2) compared to the higher levels (3, 4, and 5) and the medium level (3) compared to higher levels (4 and 5). Furthermore, across a total of 38 measures, the model identified the four best predictors of the level of expertise: the sum of fixations by note, the number of blinks, the number of fixations, and the average fixation duration. Thus, efficiently classifying musical reading expertise from musicians' eye movements and performance using SVM is possible. The results have important theoretical and practical implications for music cognition and pedagogy, enhancing the specialized eye and performance behaviors required for an expert music reading.
Association of genetic variants with autism spectrum disorder in Japanese children revealed by targeted sequencing
Authors: Shiota Yuka , Nishiyama Tomoaki , Yokoyama Shigeru , Yoshimura Yuko , Hasegawa Chiaki , Tanaka Sanae , Iwasaki Sumie , Kikuchi Mitsuru
Published: August 2024

Introduction:

Autism spectrum disorders (ASD) represent a heterogeneous group of neurodevelopmental disorders with strong genetic predispositions. Although an increasing number of genetic variants have been implicated in the pathogenesis of ASD, little is known about the relationship between ASD-associated genetic variants and individual ASD traits. Therefore, we aimed to investigate these relationships.

Methods:

Here, we report a case-control association study of 32 Japanese children with ASD (mainly with high-functioning autism [HFA]) and 36 with typical development (TD). We explored previously established ASD-associated genes using a next-generation sequencing panel and determined the association between Social Responsiveness Scale (SRS) T-scores and intelligence quotient (IQ) scores.

Results:

In the genotype-phenotype analyses, 40 variants of five genes (SCN1A, SHANK3, DYRK1A, CADPS, and SCN2A) were associated with ASD/TD phenotypes. In particular, 10 SCN1A variants passed permutation filtering (false discovery rate <0.05). In the quantitative association analyses, 49 variants of 12 genes (CHD8, SCN1A, SLC6A1, KMT5B, CNTNAP2, KCNQ3, SCN2A, ARID1B, SHANK3, DYRK1A, FOXP1, and GRIN2B) and 50 variants of 10 genes (DYRK1A, SCN2A, SLC6A1, ARID1B, CNTNAP2, SHANK3, FOXP1, PTEN, SCN1A, and CHD8) were associated with SRS T- and IQ-scores, respectively.

Conclusion:

Our data suggest that these identified variants are essential for the genetic architecture of HFA.
The genetic cause of neurodevelopmental disorders in 30 consanguineous families
Authors: Paracha Sohail Aziz , Nawaz Shoaib , Tahir Sarwar Muhammad , Shaheen Asmat , Zaman Gohar , Ahmed Jawad , Shah Fahim , Khwaja Sundus , Jan Abid , Khan Nida , Kamal Mohammad Azhar , Alam Qamre , Abbas Safdar , Farman Saman , Waqas Ahmed , Alkathiri Afnan , Hamadi Abdullah , Santoni Federico , Ullah Naseeb , Khalid Bisma , Antonarakis Stylianos E. , Fakhro Khalid A , Umair Muhammad , Ansar Muhammad
Published: August 2024

Objective

This study aims to clinically and genetically assess 30 unrelated consanguineous Pakistani families from various ethnic backgrounds, all exhibiting features of neurodevelopmental disorders (NDDs).

Methods

We conducted clinical, genetic, biochemical, and molecular analyses on 30 consanguineous families with NDDs enrolled from various regions of Pakistan. The likely molecular causes of primary microcephaly and NDDs were identified. Detailed clinical investigations and molecular diagnoses were performed using whole exome sequencing (WES) of the proband, followed by Sanger sequencing for validation and segregation in the available family members of the affected families.

Results

WES identified likely disease-causing homozygous variants in 30 unrelated consanguineous families. Six families presented newly described variants in known NDD-related genes: ABAT (c.1439 T > G; p.Phe480Cys) [OMIM613163], SLC12A6 (c.2865_2865insT; p.Glu955Asnfs*5) [OMIM 218000], SHANK3 (c.1305-3_1,305-2delTT; p.Gln29-_Gly305del) [OMIM 606232], BCKDK (c.356_356insC; p.Gly119Alafs*24) [OMIM 614923], DDHD2 (c.2065G > T; p.Asp689Tyr) [OMIM 615033], ERCC2 (c.1255G > A; p.Glu419Lys) [OMIM 610756]. Additionally, 12 families had previously reported disease-causing variants associated with different types of NDDs: ATRX (c.109C > T; p.Arg37*) [OMIM 309580], GPR56 [ADGRG1] (c.1423C > T; p.Arg475*) [OMIM 606854], NAGLU (c.1694G > A; p.Arg565Gln) [OMIM 252920], DOLK (c.3G > A; p.Met1Ile) [OMIM 610768], GPT2 (c.815C > T; p.Ser272Leu) [OMIM 616281], DYNC1I2 (c.607 + 1G > A; p.?) [OMIM 618492], FBXL3 (c.885delT; p.Leu295Phefs25*) [OMIM 606220], LINGO1 (c.869G > A; p.Arg290His) [OMIM 618103], and ASPM (c.3978G > A; Trp1326*, c.9557C > G; p.Ser3186*, c.6994C > T; p.Arg2332*) [OMIM 608716]. All the identified variants showed segregation compatible with autosomal recessive inheritance.

Conclusion

In the present study, we observed a high frequency of ASPM variants in the genetic analysis of 30 consanguineous families exhibiting features of NDDs, particularly those associated with autosomal recessive primary microcephaly. These findings contribute to studies on genotype–phenotype correlation, genetic counseling for families, and a deeper understanding of human brain function and development.
Exendin-4-enriched exosomes from hUCMSCs alleviate diabetic nephropathy via gut microbiota and immune modulation
Authors: Wang Liping , Liang Aihua , Huang Jukai
Published: August 2024

Introduction

Diabetic nephropathy (DN) presents a significant therapeutic challenge, compounded by complex pathophysiological mechanisms. Recent studies suggest Exendin-4 (Ex-4) as a potential ameliorative agent for DN, albeit with unclear mechanisms. This research investigates the effects and underlying mechanisms of Ex-4-enriched exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSCs) on DN, focusing on their renoprotective properties and interactions with gut microbiota.

Method

Exosomes from hUCMSCs (hUCMSCs-Exo) were loaded with Ex-4 via electroporation. A streptozotocin (STZ) -induced DN mouse model was employed to assess the therapeutic impact of these engineered exosomes. The study further explored immune cell dynamics, mainly CD4+ regulatory T (Treg) cells, using bioinformatics, flow cytometry, and the influence of gut microbiota through antibiotic treatment and specific bacterial reintroduction.

Results

Treatment with hUCMSCs-Exo@Ex-4 significantly improved key DN markers, including blood glucose and proteinuria, alleviating kidney damage. A notable decrease in natural Treg cell infiltration in DN was observed, while Ex-4-loaded exosomes promoted CD4+ Treg cell induction. The therapeutic benefits of hUCMSCs-Exo@Ex-4 were diminished upon CD4+ Treg cell depletion, underscoring their role in this context. Notably, CD4+ Treg cell induction correlated with the presence of Prevotella species, and disruption of gut microbiota adversely affected these cells and the therapeutic efficacy of the treatment. However, the reintroduction of Prevotella strains counteracted these adverse effects.

Discussion

This study elucidates a novel therapeutic mechanism of Ex-4-loaded hUCMSCs exosomes in DN, highlighting the induction of CD4+ Treg cells mediated by specific gut microbiota components. These findings underscore the potential of leveraging gut microbiota and immune cell interplay in developing effective DN treatments.
Bioprospecting of inhibitors of EPEC virulence from metabolites of marine actinobacteria from the Arctic Sea
Authors: Pylkkö Tuomas , Schneider Yannik Karl-Heinz , Rämä Teppo , Andersen Jeanette Hammer , Tammela Päivi
Published: August 2024

A considerable number of antibacterial agents are derived from bacterial metabolites. Similarly, numerous known compounds that impede bacterial virulence stem from bacterial metabolites. Enteropathogenic Escherichia coli (EPEC) is a notable human pathogen causing intestinal infections, particularly affecting infant mortality in developing regions. These infections are characterized by microvilli effacement and intestinal epithelial lesions linked with aberrant actin polymerization. This study aimed to identify potential antivirulence compounds for EPEC infections among bacterial metabolites harvested from marine actinobacteria (Kocuria sp. and Rhodococcus spp.) from the Arctic Sea by the application of virulence-based screening assays. Moreover, we demonstrate the suitability of these antivirulence assays to screen actinobacteria extract fractions for the bioassay-guided identification of metabolites. We discovered a compound in the fifth fraction of a Kocuria strain that interferes with EPEC-induced actin polymerization without affecting growth. Furthermore, a growth-inhibiting compound was identified in the fifth fraction of a Rhodococcus strain. Our findings include the bioassay-guided identification, HPLC-MS-based dereplication, and isolation of a large phospholipid and a likely antimicrobial peptide, demonstrating the usefulness of this approach in screening for compounds capable of inhibiting EPEC virulence.
Association between air pollution and cerebrospinal fluid alpha-synuclein in urban elders: the CABLE study
Authors: Wang An-Yi , Hu He-Ying , Sun Yan , Ou Ya-Nan , Ma Ya-Hui , Li Meng , Li Qiong-Yao , Tan Lan
Published: August 2024

Introduction

Increasing evidence suggests that air pollution has a significant impact on the development of synucleinopathies, but the potential neurobiological mechanisms are unknown. We aimed to explore the associations of air pollution (including ozone [O3], nitrogen dioxide [NO2], and particulate matter [PM2.5]) with CSF α-syn levels in urban older adults.

Methods

We included 933 urban participants from the Chinese Alzheimer’s Biomarker and LifestylE study. The 5-year average levels of air pollution exposure were estimated in the areas of residence. Multivariate linear regression was conducted to detect the correlation of air pollution with CSF α-syn levels. Subgroup analyses by age, gender, season, and history of coronary heart disease (CHD) were performed. Moreover, restricted cubic spline (RCS) models were applied to explore the potential nonlinear relationships.

Results

We found a significant correlation of CSF α-syn level with PM2.5 in urban participants. Specifically, multiple linear regression showed a significant negative association between PM2.5 and CSF α-syn level (p = 0.029), which was more significant in female, midlife, non-CHD, and cold season subgroups. Besides, RCS models showed that O3 had an inverse J-shaped association with CSF α-syn levels in urban participants (p for nonlinearity = 0.040), and the harmful effect possibly appeared when O3 was above 37.9 ppb.

Discussion

Long-term exposure to air pollution was associated with lower CSF α-syn levels, which may offer a new direction for exploring and preventing synucleinopathies.
Effects of motor imagery-based brain-computer interface-controlled electrical stimulation on lower limb function in hemiplegic patients in the acute phase of stroke: a randomized controlled study
Authors: Luo Xi
Published: August 2024

Background

Lower limb motor dysfunction is one of the most serious consequences of stroke; however, there is insufficient evidence for optimal rehabilitation strategies. Improving lower limb motor function through effective rehabilitation strategies is a top priority for stroke patients. Neuroplasticity is a key factor in the recovery of motor function. The extent to which neuroplasticity-based rehabilitation therapy using brain-computer interface (BCI) is effective in treating lower limb motor dysfunction in acute ischemic stroke patients has not been extensively investigated.

Objective

This study aimed to assess the impact of BCI rehabilitation on lower limb motor dysfunction in individuals with acute ischemic stroke by evaluating motor function, walking ability, and daily living activities.

Methods

This study was conducted in a randomized controlled trial, involving 64 patients with acute ischemic stroke who experienced lower limb motor dysfunction. All patients were divided into two groups, with 32 patients assigned to the control group was given conventional rehabilitation once a day for 70 min, 5 times a week for 2 weeks, and the experimental group (n = 32) was given BCI rehabilitation on top of the conventional rehabilitation for 1 h a day, 30 min of therapy in the morning and an additional 30 min in the afternoon, for a total of 20 sessions over a two-week period. The primary outcome was lower extremity motor function, which was assessed using the lower extremity portion of the Fugl-Meyer Rating Scale (FMA-LE), and the secondary endpoints were the Functional Ambulation Scale (FAC), and the Modified Barthel index (MBI).

Results

After 20 sessions of treatment, both groups improved in motor function, walking function, and activities of daily living, and the improvements in FMA-LE scores (p < 0.001), FAC (p = 0.031), and MBI (p < 0.001) were more pronounced in the experimental group compared with the control group.

Conclusion

Conventional rehabilitation therapy combined with BCI rehabilitation therapy can improve the lower limb motor function of hemiplegic patients with stroke, enhance the patient’s ability to perform activities of daily living, and promote the improvement of walking function, this is an effective rehabilitation policy to promote recovery from lower extremity motor function disorders.