bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel approach to idursulfase and laronidase desensitization in type 2 and type 1 S mucopolysaccharidosis (MPS)
Authors: Spataro Federico , Viggiani Fabio , Macchia Domenico Giorgio , Rollo Valentina , Tummolo Albina , Suppressa Patrizia , Sabba’ Carlo , Rossi Maria Pia , Giliberti Lucia , Satriano Francesco , Nettis Eustachio , Di Bona Danilo , Caiaffa Maria Filomena , Fischetto Rita , Macchia Luigi
Published: November 2022

Background:

Idursulfase and laronidase are drugs used to treat Hunter syndrome (mucopolysaccharidosis type 2) and Scheie syndrome (mucopolysaccharidosis type 1 S), respectively. These are rare lysosomal storage disorders, leading to accumulation of glycosaminoglycans within lysosomes. Failure of early recognition of the disease and/or delay in starting the appropriate treatment result in severe clinical impairment and death. For almost 20 years, enzyme replacement therapy with recombinant proteins has represented the first line therapeutic option. However, administration of idursulfase and laronidase is associated with infusion-related hypersensitivity reactions, in approx. 20% of patients. In these patients, rapid desensitization by intravenous administration protocols has been used in order to avoid treatment discontinuation. This approach proved effective and safe. However, long-term tolerance could not be achieved. Thus, we decided to combine rapid desensitization with allergen immunotherapy-like desensitization.

Results:

Two patients with Hunter syndrome and one patient with Scheie syndrome developed severe allergy to idursulfase and laronidase, respectively, preventing them from continuing the otherwise indispensable therapy. In all three patients, the possible IgE-mediated nature of the reactions suffered was suggested by positive skin tests with the two enzymes, respectively. By devising 12-step, 3-dilution rapid desensitization protocols, we resumed the enzyme replacement therapy. However, the prolonged time required for administration (a not negligible pitfall, since therapy should be given weekly for life) and the persistent occurrence of reactions (mild but still requiring anti-allergic medication at full dosage) led us to combine rapid desensitization with a compact 11-step, 24-day allergen immunotherapy-like desensitization protocol. Thus, idursulfase and laronidase were injected subcutaneously, with a 500-fold increase from step 1 to step 11 for idursulfase and a 222-fold increase for laronidase. This strategy led to restoration of long-term tolerance, allowing weekly intravenous therapy administration under standard conditions, according to the manufacturer instructions, in the absence of side effects and with only precautionary low-dose premedication.

Conclusion:

Rapid desensitization is a suitable and safe option in the case of idursulfase and laronidase allergy. Combination with subcutaneous allergen immunotherapy-like desensitization afforded restoration of enzyme replacement therapy given by the normal administration schedule, by inducing sustained tolerance.
Telehealth exercise to Improve Physical function and frailty in patients with multiple myeloma treated with autologous hematopoietic Stem cell transplantation (TIPS): protocol of a randomized controlled trial
Authors: Lee Kyuwan , Nathwani Nitya , Shamunee Justin , Lindenfeld Lanie , Wong F. Lennie , Krishnan Amrita , Armenian Saro
Published: November 2022

Background

Advances in autologous hematopoietic stem cell transplantation (HSCT) and supportive care have led to marked improvements in survival for patients with multiple myeloma. Despite these improvements, patients with multiple myeloma remain at high risk of physical dysfunction and frailty due to HSCT and its associated exposures. Although traditional supervised exercise programs can improve frailty in cancer patients and survivors, rehabilitation facilities are typically far from a patient’s residence, are offered on fixed days/hours, contain uniform activities for everyone, and carry a higher risk of contact cross-infection due to immunosuppression, which can be barriers to exercise participation. Innovative personalized interventions are needed to overcome the limitations of traditional exercise interventions. The purpose of this study is to determine the efficacy and sustainability of a telehealth exercise intervention on physical function and frailty in patients with multiple myeloma treated with HSCT.

Methods

This randomized controlled trial will assess the efficacy of an 8-week telehealth exercise intervention in 60 patients with multiple myeloma who underwent autologous HSCT (30–180 days post-transplant) and are pre-frail or frail. There will be 30 intervention participants and 30 delayed controls. We will administer remote baseline assessments (week 0), followed by an 8-week telehealth intervention (week 1–8), post assessment (week 9), and an additional follow-up assessment (week 17). Our primary endpoint will be improved physical function, as assessed by the Short Physical Performance Battery test. Our secondary endpoint will be a decrease in frailty characteristics such as gait speed, strength, and fatigue. We will also evaluate the sustainability of improved physical function and frailty at week 17. Participants randomized to the intervention group will perform at least 90 min of exercise per week throughout the 8 weeks.

Discussion

This study will help optimize the delivery of safe, low-cost, and scalable telehealth exercise interventions to improve health outcomes in patients with multiple myeloma, an understudied population at high risk for physical dysfunction and frailty. Our study may provide the foundation for sustainable telehealth exercise interventions to improve physical function and frailty for other hematologic cancer patients (e.g., acute leukemia, lymphoma) as well as any other cancer population of interest.

Trial registration

ClinicalTrials.govNCT05142371. This study was retrospectively registered on December 2nd, 2021, and is currently open to accrual.
Development of a Multidimensional Pain Questionnaire in Professional Dance (MPQDA): a pilot study
Authors: Haenel Jasmin , Schoettker-Koeniger Thomas , Wanke Eileen M.
Published: November 2022

Background

Pain is part of the everyday life of professional dancers. It can indicate health risks and impair the ability to work. Suitable screening tools can be used to identify pain and its risk potential. A comprehensive, multidimensional, differentiated assessment tool for pain in professional dance does not currently exist.

Methods

An initial questionnaire was developed in German and English and was assessed in a qualitative pretest. In a field study with a cross-sectional design including n = 72 dancers from Germany (n = 36 responses each in the English and German language versions), the questionnaire was optimized by item analysis, its psychometric properties (dimensionality, construct validity, reliability) were examined and the ability of the pain dimensions to classify the subjective ability to work in training was analyzed (ROC analysis).

Results

The developedMultidimensional Pain Questionnaire in Professional Dance(MPQDA) was reduced and optimized in its psychometric properties. Following questions were reduced in their items or answer categories: pain localizations (from 20 to 15 regions), accompanying symptoms (from 6 to 3 items), sensory and affective pain quality (from 20 to 10 items), pain frequency (from 4 to 3 answer categories), and the motives of working with pain (from 14 to 12 items). Regarding the subjective ability to work in training, the variables of the ability to work in rehearsals and in performances, as well as the accompanying symptoms of tension and mobility restrictions, showed a relatively good classification ability (Area under the Curve (AUC) ≥ 0.7 in the 95% confidence interval) and significant, moderate to strong correlations (Somers' D > 0.25,p < 0.05). The classification ability of the other pain dimensions was largely absent or poor.

Conclusion

The MPQDA differentiates various pain dimensions in professional dancers and is available in a compatible manner in German and English. The clinical relevance needs to be explored further in the future.
Complete response to nivolumab in Kirsten rat sarcoma virus oncogene KRAS-G12C mutant metastatic lung adenocarcinoma: a case report
Authors: Boby Jeffrey Mathew , Mohd Ghazali Nurul Nadia , Mani Anita , George Mathew
Published: November 2022

Background

The advent of immunotherapies has ushered in a new era in the treatment of non-small cell lung carcinoma. Although immunotherapies are associated with improved clinical outcomes, studies report a median overall survival of 11 months with progression-free survival of 2.5 months with the use of nivolumab for pretreated metastatic non-small cell lung cancer. Herein, we describe a case of advanced non-small cell lung carcinoma that has shown exceptional response to immunotherapy, with the patient being in complete response for the past 6 years since commencement of nivolumab.

Case presentation

We report the case of a 58-year-old female Caucasian, an ex-smoker with 40-pack-year history of smoking, who presented with cough and chest pain and was subsequently diagnosed with metastatic pulmonary adenocarcinoma. The tumor was positive for Kirsten rat sarcoma virus oncogene KRAS-G12C mutation and had high programmed death-1 ligand expression. She was commenced on first-line chemotherapy with carboplatin and gemcitabine with disease response, then continued on maintenance pemetrexed. She was then commenced on immunotherapy with nivolumab, with complete response for a total of 6 years. She does not report any adverse events. Currently, she shows no evidence of recurrence of non-small cell lung carcinoma.

Conclusion

The exceptional response to immunotherapy seen in this case may be explained by the presence of Kirsten rat sarcoma virus oncogene mutation, which is associated with enhanced clinical response to programmed death-1 ligand inhibitors. This report emphasizes the urgent need for further studies evaluating the role of Kirsten rat sarcoma virus oncogene mutation in determining the clinical efficacy of immunotherapies. This would enable us to make effective evidence-based clinical interventions in the treatment of non-small cell lung carcinoma.
Generating evidence for diagnosis and therapy of RarE LIVEr disease: the RELIVE Initiative for systematic reviews and meta-analyses
Authors: Fuchs Juri , Murtha-Lemekhova Anastasia , Pfeiffenberger Jan , Fichtner Alexander , Günther Patrick , Halama Niels , Mayer Philipp , Hornuss Daniel , Klotz Rosa , Probst Pascal , Hoffmann Katrin ,   for the RELIVE Initiative
Published: November 2022

Background

Rare liver lesions and diseases have seldomly aroused major interest of researchers. For most guidelines, presumably similar clinical conditions are pooled without detailed investigations of singularities that they present.

Main text

A multidisciplinary project aiming to establish evidence-based therapies for rare liver diseases has been founded. A series of systematic reviews and meta-analyses will be the starting point for a structured development of guidelines for rare conditions of the liver affecting pediatric and adult populations. The novel approach will be focusing on case reports and small patient series with distinct rare liver diseases without pooling several presumably acceptably similar conditions. Thus, a vital resource of information will be utilized, which has been largely neglected hitherto.

Conclusion

Highly specific recommendations based on highest available evidence will therefore be developed for specific conditions, advancing the individualized medicine approach for the afflicted patients.
Hankel operators between different doubling Fock spaces
Authors: Chen Jianjun , Xu Guangxia
Published: November 2022

In this paper, we study Hankel operators on the doubling Fock spaces for all possible $1\leq p,q<\infty $
1
≤
p
,
q
<
∞
. We characterize those symbols f for which the Hankel operators $H_{f}$

H
f

and $H_{\bar{f}}$

H

f
¯

are simultaneously bounded or compact from doubling Fock space $F^{p}_{\varphi}$

F
φ
p

to Lebesgue space $L^{q}_{\varphi}$

L
φ
q

, where φ is a nonzero subharmonic function such that $\Delta \varphi \,dA$
Δ
φ

d
A
is a doubling measure.
Shrinkage and mechanical properties of drying oil paints
Authors: Janas Arkadiusz , Mecklenburg Marion F. , Fuster-López Laura , Kozłowski Roman , Kékicheff Patrick , Favier Damien , Andersen Cecil Krarup , Scharff Mikkel , Bratasz Łukasz
Published: November 2022

Understanding how the evolving molecular composition of an oil paint layer on its transition to an aged solid film affects its dimensional change and mechanical properties is fundamental to the assessment of material durability and more broadly risk of degradation of oil paintings. Tensile properties—modulus of elasticity and strain at break—as well as cumulative shrinkage were determined for a selection of oil paints from Mecklenburg’s Paint Reference Collection now after approximately 30 years of drying. The oil paints were found to get stiffer and more brittle with diminishing plastic deformation and increasingly elastic behaviour. For some paints, the increases in stiffness and decreases in the strain at break were dramatic during the late stage of drying. The observations modify the current physical model of paintings in which the mismatch in the response of glue-based ground layer and unrestrained wood or canvas support to variations in relative humidity (RH) has been identified as the worst-case condition for the fracturing of the entire pictorial layer. This study demonstrated that some paints were more brittle than the glue-based ground layer and as a consequence more vulnerable to cracking. The shrinkage of paints due to molecular relocation and/or evaporation of organic medium as they dry and age was measured. This shrinkage can exceed their strain at break and lead to fracturing of the oil paint layer if it is restrained by a dimensionally stable substrate. Consequently, after long-term drying, the cumulative shrinkage can cause oil paints to crack even in absence of fluctuations in RH or temperature. An example of cracking developed in an oil paint layer on the top of an undamaged ground layer in a historic panel painting was made evident by the X-ray microtomography.
3D printed model for triple negative inflammatory breast cancer
Authors: Huang Yu-Hui , Tuttle Todd M. , Hoven Noelle
Published: November 2022

Background

Access to imaging reports and review of the breast imaging directly with a patient with breast cancer helps improve the understanding of disease extent and severity. A 3D printed breast model can further enhance a patient’s understanding and communication with the healthcare team resulting in improved patient comprehension and patient input with reduced treatment decision conflict. Furthermore, 3D printed models can facilitate training of residents and fellows involved in the diagnosis and treatment management of breast cancer.

Case presentation

We present a 3D printed breast tumor model segmented from positron electron tomography/computed tomography and fabricated via desktop vat polymerization as proof of concept for treatment planning for a patient diagnosed with triple negative inflammatory breast carcinoma.

Conclusion

We illustrate benefits and indications for 3D printing in the management of breast cancer and specifically inflammatory breast cancer in this case. Fabrication and implementation of 3D printed models enhances patient’s understanding and communication with the healthcare team regarding their condition, treatment options and anticipated outcomes. It provides personalized treatment planning by examining patient-specific pathology and the anatomic spatial relationships. Furthermore, 3D printed models facilitate medical education for trainees across disciplines involved in the patient’s care.
A Unified Model of Cohort Mortality
Authors: Lleras-Muney Adriana , Moreau Flavien
Published: November 2022

We propose a dynamic production function of population health and mortality from birth onward. Our parsimonious model provides an excellent fit for the mortality and survival curves for primate and human populations since 1816. The model sheds light on the dynamics behind many phenomena documented in the literature. Simple extensions of the model can reproduce (1) the existence and evolution of mortality gradients across socioeconomic statuses documented in the literature, (2) nonmonotonic dynamic effects of in utero shocks, (3) persistent or scarring effects of wars, and (4) mortality displacement after large temporary shocks, such as extreme weather.
The Unequal Impact of the COVID-19 Pandemic on Infant Health
Authors: Torche Florencia , Nobles Jenna
Published: November 2022

The COVID-19 pandemic has taken a large toll on population health and well-being. We examine the consequences of prenatal exposure for infant health, through which the pandemic may have lasting intergenerational effects. We examine multiple pathways by which the pandemic shaped birth outcomes and socioeconomic disparities in these consequences. Analysis of more than 3.5 million birth records in California with universal information on COVID infection among persons giving birth at the time of delivery reveals deep inequalities in infection by education, race/ethnicity, and place-based socioeconomic disadvantage. COVID infection during pregnancy, in turn, predicts a large increase in the probability of preterm birth, by approximately one third. At the population level, a surprising reduction in preterm births during the first months of the pandemic was followed by an increase in preterm births during the surge in COVID infections in the winter of 2021. Whereas the early-pandemic reduction in preterm births benefited primarily highly educated mothers, the increase in preterm births during the winter infection surge was entirely concentrated among mothers with low levels of schooling. The COVID-19 pandemic is expected to exacerbate U.S. inequality in multiple ways. Our findings highlight a particularly enduring pathway: the long-term legacy of prenatal exposure to an unequal pandemic environment.
Celsr1 suppresses Wnt5a-mediated chemoattraction to prevent incorrect rostral migration of facial branchiomotor neurons
Authors: Hummel Devynn , Becks Alexandria , Men Hongsheng , Bryda Elizabeth C. , Glasco Derrick M. , Chandrasekhar Anand
Published: November 2022

In the developing hindbrain, facial branchiomotor (FBM) neurons migrate caudally from rhombomere 4 (r4) to r6 to establish the circuit that drives jaw movements. Although the mechanisms regulating initiation of FBM neuron migration are well defined, those regulating directionality are not. In mutants lacking the Wnt/planar cell polarity (PCP) component Celsr1, many FBM neurons inappropriately migrate rostrally into r3. We hypothesized that Celsr1 normally blocks inappropriate rostral migration of FBM neurons by suppressing chemoattraction towards Wnt5a in r3 and successfully tested this model. First, FBM neurons in Celsr1; Wnt5a double mutant embryos never migrated rostrally, indicating that inappropriate rostral migration in Celsr1 mutants results from Wnt5a-mediated chemoattraction, which is suppressed in wild-type embryos. Second, FBM neurons migrated rostrally toward Wnt5a-coated beads placed in r3 of wild-type hindbrain explants, suggesting that excess Wnt5a chemoattractant can overcome endogenous Celsr1-mediated suppression. Third, rostral migration of FBM neurons was greatly enhanced in Celsr1 mutants overexpressing Wnt5a in r3. These results reveal a novel role for a Wnt/PCP component in regulating neuronal migration through suppression of chemoattraction.
Stress-induced phase separation of ERES components into Sec bodies precedes ER exit inhibition in mammalian cells
Authors: van Leeuwen Wessel , Nguyen Dan T. M. , Grond Rianne , Veenendaal Tineke , Rabouille Catherine , Farías Ginny G.
Published: November 2022

Phase separation of components of ER exit sites (ERES) into membraneless compartments, the Sec bodies, occurs in Drosophila cells upon exposure to specific cellular stressors, namely, salt stress and amino acid starvation, and their formation is linked to the early secretory pathway inhibition. Here, we show Sec bodies also form in secretory mammalian cells upon the same stress. These reversible and membraneless structures are positive for ERES components, including both Sec16A and Sec16B isoforms and COPII subunits. We find that Sec16A, but not Sec16B, is a driver for Sec body formation, and that the coalescence of ERES components into Sec bodies occurs by fusion. Finally, we show that the stress-induced coalescence of ERES components into Sec bodies precedes ER exit inhibition, leading to their progressive depletion from ERES that become non-functional. Stress relief causes an immediate dissolution of Sec bodies and the concomitant restoration of ER exit. We propose that the dynamic conversion between ERES and Sec body assembly, driven by Sec16A, regulates protein exit from the ER during stress and upon stress relief in mammalian cells, thus providing a conserved pro-survival mechanism in response to stress.
Tag-based estimates of bottlenose dolphin swimming behavior and energetics
Authors: Gabaldon Joaquin T. , Zhang Ding , Rocho-Levine Julie , Moore Michael J. , van der Hoop Julie , Barton Kira , Shorter K. Alex
Published: November 2022

Current estimates of marine mammal hydrodynamic forces tend to be made using camera-based kinematic data for a limited number of fluke strokes during a prescribed swimming task. In contrast, biologging tag data yield kinematic measurements from thousands of strokes, enabling new insights into swimming behavior and mechanics. However, there have been limited tag-based estimates of mechanical work and power. In this work, we investigated bottlenose dolphin (Tursiops truncatus) swimming behavior using tag-measured kinematics and a hydrodynamic model to estimate propulsive power, work and cost of transport. Movement data were collected from six animals during prescribed straight-line swimming trials to investigate swimming mechanics over a range of sustained speeds (1.9–6.1 m s−1). Propulsive power ranged from 66 W to 3.8 kW over 282 total trials. During the lap trials, the dolphins swam at depths that mitigated wave drag, reducing overall drag throughout these mid- to high-speed tasks. Data were also collected from four individuals during undirected daytime (08:30–18:00 h) swimming to examine how self-selected movement strategies are used to modulate energetic efficiency and effort. Overall, self-selected swimming speeds (individual means ranging from 1.0 to 1.96 m s−1) tended to minimize cost of transport, and were on the lower range of animal-preferred speeds reported in literature. The results indicate that these dolphins moderate propulsive effort and efficiency through a combination of speed and depth regulation. This work provides new insights into dolphin swimming behavior in both prescribed tasks and self-selected swimming, and presents a path forward for continuous estimates of mechanical work and power from wild animals.
Coping methods among Polish students during Covid-19 pandemic
Authors: Kawalec Alicja , Wilczyński Krzysztof Maria , Biecka Adrianna , Krupnik Dominika , Grabowski Wojciech , Janas - Kozik Małgorzata
Published: November 2022

Cel pracy

Pandemia Covid-19 drastycznie zmieniła codzienną rzeczywistość i zmusiła całe społeczeństwa do wypracowania nowych metod radzenia sobie ze stresem. Studenci stanowili grupę, której rytm dnia i pracy został drastycznie zmieniony. Przeprowadzona analiza sposobów adaptacji do przewlekłego stresu wraz z oceną ich skuteczności, może pomóc jednostkom i grupom społecznym najbardziej narażonym na stres.

Metoda

Analiza metod radzenia sobie ze stresem oraz poziomu agresji została przeprowadzona za pomocą kwestionariuszy Brief COPE i STAXI-2 na grupie 283 uczestników, wyłonionych z grupy 906 osób biorących udział w początkowej fazie badania. Badanie odbyło się pomiędzy drugą i trzecią falą pandemii w Polsce.

Wyniki

W badanej grupie przeważały pozytywne metody radzenia sobie ze stresem, takie jak aktywne działanie, wykorzystanie wsparcia informacyjnego oraz planowanie. Negatywne metody były nieodłącznie związane z wyższym poziomem agresji. Oba te elementy przeważały u kobiet w sposób istotny statystycznie.

Wnioski

Pierwsze sygnały dotyczące patologicznych metod radzenia sobie ze stresem mogą być subtelne i ukryte w potencjalnie zwyczajnych reakcjach na stresujące zdarzenia. Należy być świadomym ich obecności, aby móc zapewniać lepszą pomoc wśród środowisk nie tylko studenckich, a także innych znacząco narażonych na chroniczny stres.
The Quantum Hamilton–Jacobi Equation and the Link Between Classical and Quantum Mechanics
Authors: Fusco Girard Mario
Published: November 2022

We study how the classical Hamilton's principal and characteristic functions are generated from the solutions of the quantum Hamilton–Jacobi equation. While in the classically forbidden regions these quantum quantities directly tend to the classical ones, this is not the case in the allowed regions. There, the limit is reached only if the quantum fluctuations are eliminated by means of coarse-graining averages. Analogously, the classical Hamilton–Jacobi scheme bringing to the motion's equations arises from a similar formal quantum procedure.Quanta 2022; 11: 42–52.
Futures for Youth by Youth: How Dreams of a Better Future Inspired a Youth Movement to Protect the Bagmati River
Authors: Sharpe Adam , Dixit Avini , Pandey Sadip Raj , Agad Leizl
Published: November 2022

Investment in young people’s human, social and cultural capital is critical to achieving the UN’s sustainable development goals. How can we empower them to participate in development policies and practices to reach their fullest potential, maximizing their contribution to a better future for all? This paper centers around a story of youth inclusion and leadership to protect the Bagmati River that flows through the Kathmandu valley of Nepal.
Stepping Into ‘Power With’
Authors: Aquilina Eunice
Published: November 2022

Supporting women to re-author their inherited relationship to power, shifting from the dominant narrative of ‘power over’ to ‘power with’ not only allows women individually to step into their power, it also allows organisations and wider society to harness their wisdom. Drawing on action research, the author shares an approach which can bring about a ripple of cultural change in organisations, one conversation at a time. It is an approach that is much needed if leaders and even humankind itself are to adapt and thrive in these challenging times.
Rewiring the Leadership Mindset for a Preferred Future in a Post-Covid World
Authors: Martin Mercedes , Wasserman Ilene
Published: November 2022

We are living through one of the most turbulent times in history, in the vortex of the intersection of the impacts of a pandemic, climate change acceleration and political polarization at a global level. Now, more than ever, all that we have learned in our work around creating equity, leveraging diversity and fostering inclusive cultures provides the foundational curriculum for dealing with this turbulent state. ‘Sustainable equity’ provides a framework for leaders who care about doing the right thing for their employees, their organizations and communities.
Debiasing the Disposition Effect with Noninvasive Brain Stimulation: The Role of Cognitive Control
Authors: Niu Xiaofei , Li Jianbiao , Li Dahui , Cao Qian
Published: November 2022

This study tests whether modulating a brain region associated with cognitive control using noninvasive brain stimulation affects the disposition effect. A participant trades stocks in an experimental asset market while their level of cognitive control is exogenously manipulated by applying weak current stimulation to a control-related cortical region. We find that the stimulation significantly affects the participant’s cognitive control and tendency to exhibit the disposition effect. This result is also obtained for financial professionals. We thus provide evidence that cognitive control is important for the disposition effect.

This paper was accepted by Bruno Biais, finance.

Funding: X. Niu acknowledges financial support from the National Natural Science Foundation of China [Grant 72203132], Taishan Scholar Program of Shandong Province [Grant tsqn201909013], and Natural Science Foundation of Shandong Province [Grant ZR2022QG048]. J. Li acknowledges financial support from the National Social Science Foundation of China [Grant 20AZD044], Natural Science Foundation of Shandong Province [Grant ZR2022MG068], and Project of Humanities and Social Sciences of Shandong University [Grant 21RWZD15]. Q. Cao acknowledges financial support from the Social Science Foundation of Jiangsu Province [Grant 21GLC006]. The authors also acknowledge financial support from the Major Project of the National Natural Science Foundation of China [Grant 72192842].

Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2022.4596 .
CULTURAS ESTELARES COM PLANETÁRIO: VIAGENS PELA ASTRONOMIA DE POVOS ORIGINÁRIOS
Authors: Rodrigues Izabela Cristina Bittencourt , Pitta Ana Carolina , Ribeiro Caroline , Oliveira Bruno Henrique Gonçalves de , Colonese Paulo Henrique
Published: November 2022

A Coleção Culturas Estelares, produzida por um grupo de planetaristas do Ciência Móvel - Museu itinerante da Fundação Oswaldo Cruz -, apresenta conhecimentos sobre as observações do céu realizadas pelas culturas Guarani, Navajo/Diné, Tukano/Desana e Maia. Fazendo uso das diferentes ferramentas disponibilizadas pelo software Stellarium, a Coleção evidenciou o uso de controle de tempo, localização e visualização de culturas estelares, apresentando a possibilidade do leitor utilizar estes recursos para observar o céu de qualquer época e local. Foi priorizada a abordagem das constelações animais, por possibilitarem viajar pela esfera celeste apresentando a rica fauna dos locais onde habitam as culturas citadas.
DESIGUALDADE ENTRE ENSINO PÚBLICO E PRIVADO: ANÁLISE DO USO DE TIC NA PANDEMIA DE COVID-19
Authors: De Oliveira Loureiro Jerônimo , Azambuja Lopes Leticia
Published: November 2022

A pandemia de Covid-19 foi marcada por uma série de adaptações na forma como a sociedade global vive. Ao longo do ano de 2020 gestores, professores, alunos e familiares precisaram remodelar processos e metodologias, para dar continuidade ao ano letivo escolar, todavia, tudo isto teve um custo. O presente estudo apresenta uma revisão de autores selecionados que discutam a temática da desigualdade social, da desigualdade no ensino e do uso de Tecnologias de Informação e Comunicação no Ensino de Ciências. Para isto, foi realizada uma revisão bibliográfica utilizando-se da metodologia de revisão crítica de literatura conforme Minayo (2009) realizada entre os meses de fevereiro e setembro de 2021. A partir deste estudo constatou-se uma evidente desigualdade entre o ensino público e privado, sobretudo, quando analisamos o uso de TIC. Também observou-se a necessidade de políticas públicas que priorizem recursos financeiros para a inserção destas tecnologias no ensino público, assim como, investimentos na formação de professores para utilização de tecnologias digitais, pois, a pandemia de Covid-19 mostrou-se um marco no que tange tais aspectos.
ATIVIDADES NÃO PRESENCIAIS NA EDUCAÇÃO INFANTIL: REFLETINDO SOBRE AS ORIENTAÇÕES E AÇÕES PEDAGÓGICAS
Authors: Melo da Rocha Nogueira Barros Maria Do Desterro , Brito Antonia Edna
Published: November 2022

A pandemia mundial do coronavírus (SARS-CoV-2) tem provocado uma situação bastante complexa na educação escolar, tanto em relação às formas de ensinar, quanto no que se refere às aprendizagens a serem produzidas pelos estudantes. Com o propósito de contribuir para a ampliação das discussões sobre os desafios da educação pública no contexto da pandemia do coronavírus, bem como de colaborar com a socialização das ações educativas implementadas na Educação Infantil, no contexto pandêmico, o presente trabalho objetiva analisar as atividades pedagógicas realizadas pelas Redes Municipais de Ensino situadas no Território dos Carnaubais–PI, especificamente desenvolvidas com as crianças de 4 e 5 anos matriculadas na Educação Infantil. A coleta de dados foi mediante a aplicação de questionário do Google Forms respondido por 16 Supervisores da Educação Infantil que atuam nas Redes Púbicas Municipais de Ensino. Os resultados apontam que apenas 50% das redes de ensino estão seguindo plenamente as orientações do Conselho Nacional de Educação (CNE) (Parecer CNE n.º 05/2020) com relação às atividades pedagógicas não presenciais na Educação Infantil. Essa constatação deve ser objeto de reflexão por parte dos profissionais que atuam nesta etapa da Educação Básica, principalmente aqueles que são responsáveis pela condução e acompanhamento da política educacional. Os resultados do estudo apontam também a necessidade da retomada do objetivo da Educação Infantil que é promover o desenvolvimento dos aspectos físico, motor, cognitivo, social e emocional das crianças.
TESSITURAS SOBRE O SEMINÁRIO INTERNACIONAL ‘GÊNEROS, SEXUALIDADES E EDUCAÇÃO NA ORDEM DO DIA - INTERSECCIONALIDADES EM (RE)EXISTÊNCIAS’
Authors: Sepulveda Denize , York Sara Wagner , Corrêa Renan
Published: November 2022

O presente artigo tem como objetivo evidenciar o contexto no qual o "#2 Seminário Internacional Gêneros, Sexualidades e Educação na Ordem do Dia: Interseccionalidades em (Re) Existências", foi desenvolvido. Igualmente demonstra como xs coordenadorxs deste seminário tiveram a ideia de organizar o Dossiê Especial, com os resultados das apresentações das mesas de palestras e minicursos que ocorreram em agosto de 2021, durante a pandemia da COVID-19. A COVID-19 é uma doença causada pelo coronavírus, denominado SARS-CoV-2, que apresenta em espectro clínico infecções que variam de assintomáticas a quadros graves. Consideramos que o evento foi um acontecimento no sentido atribuído por Foucault, pois aconteceu como uma relação de forças no enfrentamento ao momento conservador que vivemos no Brasil. Podemos afirmar que esse seminário foi uma tática, ao modo como descrito por Michel de Certeau (2001) e, de acordo com Michel Foucault, de resistência. Segundo Certeau (2001), as táticas são gestadas em “maneiras de fazer” que se constituem em vitórias dos fracos sobre os mais fortes.
“OCUPA CAIRU”: DEMANDAS DE GÊNERO E RAÇA CONSTITUIDAS NA LUTA DO MOVIMENTO DE OCUPAÇÕES DE ESCOLA
Authors: Santos Mariana Dos Reis
Published: November 2022

O presente estudo baseia-se numa pesquisa que investigou a constituição das demandas e subjetivações de ocupantes de escola pertencentes a instituição “ Visconde de Cairu” (Ocupa Cairu),  referentes  ao debate de gênero, raça, classe e sexualidade presentes neste espaço cotidiano do movimento. A metodologia empírica utilizada consistiu na análise de entrevistas semiestruturadas durante o ano de 2016, momento da eclosão do movimento de ocupações de escola no estado do Rio de Janeiro. A noção conceitual pós estruturalista de Laclau (2016) foi utilizada, norteando as interpretações das entrevistas destes atores sociais. Também referenciamos as análises das subjetivações destas entrevistas embasando-as teoricamente através de autores do campo da Diversidade tais como: Souza( 1986), Sepulveda e Sepulveda (2016) e Gomes( 2017).A pesquisa evidenciou que embora as demandas iniciais tenham sido de natureza curricular e educacional, outras demandas da “ordem dos desejos” foram enunciadas, como analisamos nas construções discursivas apresentadas por estudantes do gênero feminino no artigo.Com isso, a luta política das ocupações de escola e sua dinâmica de organização dialógica e plural possibilitaram a estes educandos, o questionamentos a papeis de gênero na sociedade, ao disciplinamento dos corpos no ambiente escolar e a identificação com movimentos de mulheres e lgbt.
DAR FIM A ESSE MUNDO DE DÍVIDAS IMPAGÁVEIS
Authors: De Sousa Victor Pereira
Published: November 2022

A feminista negra Denise Ferreira da Silva é graduada em Sociologia pela Universidade Federal do Rio de Janeiro (UFRJ) e mestra em Sociologia e Antropologia também pela UFRJ. É doutora em Sociologia pela University of Pittsburgh e, atualmente, é professora da University of California, em San Diego, nos Estados Unidos. A Dívida Impagável é uma das poucas produções de Denise Ferreira da Silva escritas em língua portuguesa. Apesar de ser brasileira, a autora já há muito tempo faz parte da academia estadunidense e, portanto, escreve a maior parte de seus textos em língua inglesa. Contudo, existem também outros poucos artigos da autora escritos em língua portuguesa, ou traduzidos para o português, em revistas acadêmicas brasileiras (2006; 2014; 2020).
Allison, Graham. A Caminho da Guerra. Os Estados Unidos e a China conseguirão escapar da Armadilha de Tucídides?. Tradução Cássio Arantes Leite. 2020. Rio de Janeiro: Editora Intrínseca. 1ª Edição, 416p. ISBN: 9786555600346.
Authors: Silva Marcos Valle Machado da
Published: November 2022

Graham Allison analisa as relações entre a República Popular da China e os Estados Unidos da América (EUA), neste início do século XXI. Dialogando com o passado e trabalhando com cenários prospectivos, Allison apresenta possíveis desdobramentos da ascensão da China vis-à-vis com a reação dos EUA e, assim, descortina para o leitor a necessidade de as duas potências deste início de século evitarem a Armadilha de Tucídides e um potencial conflito militar.Palavras-chave: República Popular da China. Estados Unidos da América. Armadilha de Tucídides.ABSTRACTGraham Allison analyzes the relations between the People's Republic of China and the United States of America (USA) at the beginning of the 21st Century. Dialoguing with the past and working with future scenarios, Allison presents possible consequences of the rise of China vis-à-vis the US reaction and, thus, reveals to the reader the need for the two powers to avoid the Thucydides's Trap and a potential military conflict.Key words: People's Republic of China. United States of America.  Thucydides's Trap. Recebido em: 09 mai. 2022 | Aceito em: 15 ago. 2022.
O papel da extensão universitária e o campo da diversidade sexual e de gênero
Authors: Da Silva Camila Garcino
Published: November 2022

Este artigo tem como intenção refletir acerca do papel da universidade para além da pesquisa acadêmica e do ensino, trazendo breves reflexões acerca da extensão universitária em seu significado e relatos sobre uma experiência de assessoria realizada no Hospital Universitário Pedro Ernesto (HUPE/UERJ), possibilitada através de um Projeto de Extensão vinculado à Universidade do Estado do Rio de Janeiro. O objetivo deste é salientar a importância da extensão universitária e sua potencialização para a qualificação profissional e o acesso a direitos, considerando a relação direta entre a universidade e sua função educacional e social.
O lugar dos homens no Programa Bolsa Família: desafios e percepções para a inclusão
Authors: Campos Daniel De Souza
Published: November 2022

Tomando como objeto de análise a Política Nacional de Assistência Social (PNAS), o artigo busca problematizar o lugar dos homens na política de proteção social brasileira, a partir dos seguintes eixos de discussão: relações de gênero, masculinidades e proteção social. Destaca-se a reflexão sobre o acesso dos homens ao Programa Bolsa Família, visto que o seu foco reside na díade mãe-filhos e o não reconhecimento dos homens como possíveis sujeitos de direitos. Conclui-se que pensar os homens como sujeito da/na política de proteção social se constitui um desafio, sendo estratégico enfrentar a sua (in)visibilidade no acesso a este e outros programas da PNAS.
A PRÁTICA DO EXTERMÍNIO COMO DISPOSITIVO DE SEGURANÇA NO RIO DE JANEIRO
Authors: Carvalho Monique Batista
Published: November 2022

O artigo aqui apresentado propõe-se a olhar em retrospecto as políticas de segurança pública que marcaram a história do Rio de Janeiro nos últimos trinta anos, com vistas a tecer considerações sobre os mecanismos de controle da violência perpetrados como gestão de territórios e populações que engendram um modo de atuação do Estado que “faz viver e deixa morrer” (Foucault, 2002) determinados corpos.
NOTAS SOBRE DESIGUALDADE E DIVERSIDADE NO PNE
Authors: Lázaro André , Marqui Amanda
Published: November 2022

O objetivo deste artigo é discutir a articulação entre “diversidade/desigualdade” a partir da análise do Plano Nacional de Educação (Lei no 13.005/2014). Nossa proposta é refletir sobre indicadores que permitam o monitoramento das metas e estratégias relativas aos grupos sociais da “diversidade” e aqueles que sofrem “desigualdades educacionais”. Vale ressaltar que o PNE trata “desigualdades” e “diversidade” com duas atitudes distintas: “superar as desigualdades educacionais” e promover “os princípios do respeito aos direitos humanos, à diversidade”. Desigualdades e diversidade estão imbricadas de tal modo na sociedade brasileira que a crítica da desigualdade deve também considerar as condições que transformam diferenças em hierarquias e atacar os preconceitos que buscam naturalizar injustiças sociais para garantir sua reprodução. Sendo assim, as atividades de acompanhamento e monitoramento do PNE devem, portanto, adotar o ponto de vista das diretrizes e distinguir “desigualdades” e “diversidades” como dois temas articulados, porém distintos. [1] A primeira versão deste artigo foi elaborada em 2016 para o debate interno da equipe do Observatório do PNE (https://www.observatoriodopne.org.br/). Esta versão é inédita. Agradecemos à equipe do OPNE na pessoa de Vanessa Yume, coordenadora à época.
DESAFIOS ATUAIS DA EDUCAÇÃO À LUZ DA SOCIOLOGIA - APRESENTAÇÃO
Authors: Fernandes Raquel Brum , Canedo Maria Luiza
Published: November 2022

A proposta deste dossiê surgiu do nosso interesse, enquanto organizadoras, de articular discussões atuais e relevantes no campo da Sociologia da Educação, área na qual temos desenvolvido diversas atividades ao longo de nossas trajetórias acadêmicas. Articulando nossas experiências nas temáticas da violência escolar (FERNANDES, 2010), da identidade e comportamento docente (FERNANDES, 2020), da gestão escolar (CANEDO, 2018a) e das relações escola-família (CANEDO, 2018b), buscamos reunir artigos que abordassem tanto os processos sociais envolvidos no “ensinar” e no “aprender” quanto os aspectos organizacionais da educação, além das múltiplas relações sociais que constituem seu universo.
SAÚDE E DOENÇA EM PERSPECTIVA SOCIOCULTURAL: INSTITUIÇÕES, SABERES E PRÁTICAS DE CONTROLE E CURA – APRESENTAÇÃO
Authors: Carvalho Keila Auxiliadora , Alvarenga Antonia Valtéria Melo
Published: November 2022

Apresentação
PODER DE MATAR: UM ENSAIO SOBRE VIOLÊNCIA POLÍTICA
Authors: Rodrigues André , Del Río Andrés , Octaviano Daniel , Marinho Leandro
Published: November 2022

Este artigo analisa a violência – principalmente, o poder de matar – como um instrumento recorrente da política na América Latina. Para tanto, apresentamos um panorama da violência política na região e, em seguida, realizamos um estudo de caso sobre assassinatos de atores políticos na Baixada Fluminense, região do Rio de Janeiro que concentra altos índices de letalidade violenta. Estes procedimentos dão subsídio para a constatação de que as mortes violentas de atores políticos são um sintoma da reprodução de padrões autoritários de poder. Ao analisarmos levantamentos de casos de violência contra ativistas, políticos e defensores de direitos humanos em países latino-americanos, encontramos grande recorrência deste fenômeno. No estudo sobre a Baixada Fluminense, observamos que a violência política possui um papel estrutural no moro de atuação das elites políticas da região.
A MULHER E A FAMÍLIA: AGENDAS PENTECOSTAIS NA DISPUTA PELA GRAMÁTICA DOS DIREITOS HUMANOS
Authors: Teixeira Jacqueline Moraes , Barbosa Olivia Alves
Published: November 2022

Antes de assumir o Ministério da Mulher, da Família e dos Direitos Humanos do governo Bolsonaro, Damares Alves ficou conhecida por um vídeo no qual narra sua experiência de conversão vivida no alto de uma goiabeira. Reconhecida como pastora pentecostal, Damares é a primeira-ministra desde a fundação do Ministério, ocorrida em 1998, a declarar sua religião e a associá-la a seu engajamento político. Em sua posse, ela afirmou que, se o Estado era laico, a partir de agora ele teria também uma ministra terrivelmente cristã. A ascensão de Damares como ministra pode ser entendida como um marco em meio a um processo que colocou parte do segmento evangélico pentecostal na disputa pela gramática dos Direitos Humanos no país. Este artigo pretende analisar alguns sentidos dos direitos humanos no Estado Brasileiro, com foco no Poder Executivo. O objetivo central do artigo é analisar como sujeitos religiosos nas secretarias e comissões centrais traduzem a religião em políticas públicas e buscam o reconhecimento público de suas práticas como humanitárias. O artigo enfoca, portanto, o papel de sujeitos religiosos na composição de cargos na Secretaria da Família e na Secretaria da Mulher entre os anos de 2019 e 2021.
A PATRULHA MARIA DA PENHA E A POLÍTICA DE PREVENÇÃO AO FEMINICÍDIO NO ESTADO DO RIO DE JANEIRO – ANÁLISES PRELIMINARES
Authors: Sento-Sé Isadora Vianna
Published: November 2022

Este artigo busca compreender os processos que culminaram na criação e implementação do Programa Patrulha Maria da Penha – Guardiões da Vida, da Polícia Militar do Rio de Janeiro e da Ronda Maria da Penha, da Guarda Municipal, que atende mulheres com Medidas Protetivas de Urgência contra seus companheiros. A partir de dados qualitativos reunidos em entrevistas com gestores da Segurança Pública, Policiais Militares, e Guardas Municipais, é possível identificar os pontos de resistência ao programa e de concordância com ele dentro das respectivas instituições. Ainda, este artigo busca refletir como se dá a elaboração de uma política de combate e prevenção à violência contra a mulher, em um contexto no qual é priorizado o combate à violência urbana, e como os profissionais envolvidos neste processo percebem a própria atuação.
APRESENTAÇÃO
Authors: Lopes Dawisson Belém , Sousa Elizeu Santiago T. de
Published: November 2022

Apresentação do dossiê
INDEPENDÊNCIA DO BRASIL, OU O ANO DA BALEIA
Authors: Faflik David
Published: November 2022

Informado em parte pelas ideias revolucionárias do Iluminismo europeu, o movimento de independência do Brasil no século XIX garantiu, com razão, um lugar nas recentes histórias intelectuais e sociais do Ocidente. A premissa deste artigo é que as práticas culturais do Brasil revolucionário são igualmente merecedoras da atenção dos estudiosos, inclusive pela forma como essas práticas informaram o início da experiência vivida de independência entre os moradores da colônia mais valorizada de Portugal. Pedra fundamental da sociedade e da economia brasileira nas décadas que antecederam a independência, a prática cultural da caça à baleia ainda não recebeu atenção sustentada no contexto do pensamento e dos comportamentos revolucionários que caracterizaram o Brasil na época anterior, durante e imediatamente após a país alcançou sua autonomia política formal. O artigo a seguir reexamina a prática cultural da caça à baleia justamente no contexto da conquista da independência do Brasil. Fornecendo um contrapeso nesta discussão estão os laços estreitos que se estabeleceram entre os colonos do final do século XVIII na América do Norte entre sua ruptura com a Coroa inglesa e o desenvolvimento de uma indústria baleeira doméstica. Pois enquanto a experiência dos americanos na caça às baleias reforçava seu impulso pela independência política, os brasileiros, em certa medida, compraram sua liberdade política durante grande parte do século XIX por meio de uma dependência crescente dos suprimentos de óleo de baleia importado.