bluuebunny/crossref_metadata_2025 huggingface dataset:
BUILDING CITIZENSHIP AND PATRIOTISM IN ADOLESCENTS AND YOUNG PEOPLE: ON THE EXAMPLE OF GAVRILOV-YAMSKY MUNICIPAL DISTRICT OF THE YAROSLAVL REGION
Authors:   K. D. Ushinsky Yaroslavl State Pedagogical University, Afanasov A. V.
Published: November 2022

Introduction. The issue of patriotism is of great importance for the development of an individual as a citizen from an early age. The work aims to determine the level of citizenship and patriotism in teenagers and young men. The methods employed in the research include standardized interview and questionnaire “Citizenship and patriotism” (A. S. Vishnevskaya, L. I. Sarantseva). The fi ndings indicate a high level of citizenship and patriotism in both age samples. Teenagers give the overriding priority to an interest in the historical past of the country and knowledge of the basic legal acts, while the values associated with military service appear to be their low priority. Apart from an interest in culture and history, for university students, their active actions aimed at expressing their civic position come to the fore. Conclusion. The research has identifi ed the problems in the patriotic education of the students, and in this context a historical and patriotic program was formulated and tested with the view to developing youth tourism through drawing the attention of young people to history, memorable places, culture and traditions, and their studying by participating in quest games.
THE PHILOSOPHY OF FOSTERING OPTIMISM: THE AUTHOR’S INTERPRETATION OF THE IDEAS OF SARTRE-FRANKL-MAKARENKO
Authors:   Bashkir Institute of Social Technologies, Andreeva Yu. V.
Published: November 2022

Introduction. In the context of today’s crisis of education, its transfer to “online rails” due to the increased incidence of coronavirus, the issue of the development of personality in the process of education and training is still a key one. In search of principles and methods for the development of optimism as an individual quality of personality, we turned to existential analysis and a humanistic approach. Materials and methods. Research was based on the methods of analysis, synthesis, comparison, generalization, systematization of theoretical propositions by J.-P. Sartre, V.E. Frankl, A.S. Makarenko, and our interpretation of them and enabled us to conclude that A.S. Makarenko introduced the term optimism into the scientific discourse of pedagogy. The existential philosophy of the same historical period allowed the idea that a person could struggle with difficulties, courageously overcome them, relying not only on the goal, but also on persons’ own choice and sense, which is revealed in overcoming (J.-P. Sartre, V.E. Frankl). Results. Thus, we can conclude that optimism is an individual quality of personality, which is based on innate motivation for sense and acquired in the process of overcoming difficulties on the way to it, which means that it can be developed through coping with difficulties. We have identified some philosophical and pedagogical principles and methods, which, in our opinion, allow developing optimism as a kind of spiritual fortitude of a person, and this is the novelty of our research. Conclusion. The study has noted that philosophical principles and pedagogical techniques work provided there is a variability of their construction.
FEATURES OF THE PROFESSIONALIZATION OF FUTURE SPECIALISTS IN THE CONDITIONS OF MODERN CHALLENGES
Authors:   Dorzhi Banzarov Buryat State University, Bazarova T. S. , Fomitskaya G. N. ,   Dorzhi Banzarov Buryat State University
Published: November 2022

The modern social situation determines the desire of modern youth to adapt to a changing reality, to choose the most acceptable adaptation strategies. In these conditions, the problems of professional socialization of students in the educational process of the university are updated. The purpose of the article: to characterize the features of the professionalization of future specialists in social work; highlight the factors affecting the professional formation of the person in the conditions of university training. In the course of the study, the following methods were used: a set of diagnostic procedures based on pedagogical, psychological and sociological research methods (survey, questionnaire, testing, etc.) Study results. The content of the article is based on the results of monitoring studies of student youth of Buryatia conducted by the author in 2011–2022. Such features of the professional formation of the student’s personality are distinguished as the lack of awareness of applicants in choosing a future profession, the low level of their professional motivation due to obtaining a diploma as a priority goal. There are factors that determine the attitude of students to the chosen profession: the low prestige of the profession in society, work causes physical strain, insufficient level of remuneration. Comparative analysis of the monitoring study made it possible to present the characteristics of social activity of student youth as one of the factors influencing their professionalization.
CONCEPTUAL FEATURES OF THE MOTIVATION-AND-NEED COMPONENT OF THE EDUCATIONAL ACTIVITIES OF FATHERS OF VARIOUS NATIONALITIES
Authors:   Surgut State Pedagogical University, Efimova A. A.
Published: November 2022

Introduction. Russia, as a multinational country, has a large percentage of interethnic families. This feature affects the educational activities of the family and the father, in particular. Although the role of the father in the upbringing of the child differs from that of the mother, it is very important. It is the father who acts in the family as a connecting element of the system and his participation in the upbringing of children is of a stable nature, which has effect on both personal and social aspects of their development. The motivation-and-need component (as the fundamental component of any activity) is crucial in the study of the educational activity of fathers of various nationalities. The conceptual features of this component will affect the result of this activity, i.e., the development of the child. Research methods. The study employed the questionnaire “Features of Family Education” (Yu. A. Tokareva, A. A. Efimova); methodology “Motivation-and-Need Sphere of Fatherhood” (MNSF), (Yu. A. Tokareva); Mann–Whitney U test. The results of the study. The dominant motives in each national group have been established: the motive of social approval - for the Russian; the motive of achieving success in relations with the child and in their development – for the Ukrainian; the motive of self-realization in children – for the Tatar; the motive of self-affirmation – for the Armenian and Azerbaijani nationalities. Conclusion. The results obtained in the study can be used to develop psychological and pedagogical recommendations for interacting with the family.
MODERN TYPES OF BODY RELAXATION METHODS AFTER INTENSE PHYSICAL EXERTION
Authors:   V.O. Sukhomlynskyi National University of Mykolaiv, Ukraine, Molotylnikova Vira
Published: November 2022

The article presents varieties and variants of relaxation techniques advisable to use after intense physical exertion. The concept of "relaxation" and understanding of its role in physical education to maintain health and harmonious development of youth are considered. Considering the fact that one of the main trends in sports remains the increase in the intensity of training and the need to improve the results of competitions, the problem of restoring the athlete's performance capacity after physical exertion is extremely relevant today. Understanding the causes of fatigue and the physiological mechanisms of recovery, control over the relevant processes, the rational use of modern methods of body relaxation and means of recovery are important for assessing the impact of physical stress on the body, the effectiveness of training programs, identifying overtraining, determining the optimal rest time after physical exercises, and therefore, are necessary to improve the athlete's training and achieving high results.
Notes on the morphological features of cotyledonary dissecting leiomyoma, which is rare in clinical practice
Authors: Tamura Saya , Hayashi Takuma , Yaegashi Nobuo , Abiko Kaoru , Konishi Ikuo
Published: November 2022

Benign uterine leiomyoma (U.LMA) and malignant uterine leiomyosarcoma (U.LMS), which are both uterine mesenchymal tumors, are distinguished by the number of cells with mitotic activity. However, uterine mesenchymal tumors contain tumor cells with various cell morphologies; therefore, making a diagnosis, including differentiation between benign tumors and malignant tumors, is difficult. For example, A cotyledonoid dissecting leiomyoma is a uterine leiomyoma with a very rare placental lobed tissue morphology that can be misdiagnosed as a malignant uterine leiomyosarcoma because of its rarity and characteristic appearance on gross examination. Similar to the detection of a suspicious malignant mass during MRI imaging examination by medical staff, healthcare professionals must understand the characteristic appearance of a cotyledonoid dissecting leiomyoma. Clinicians and pathologists must understand the oncologic features of cotyledonoid dissecting leiomyoma to prevent misdiagnosis of malignancy and consequent overtreatment.
PEMBERDAYAAN PEREMPUAN DALAM IKLAN NIKE WOMEN VERSI ‘WHAT WILL THEY SAY ABOUT YOU?
Authors: Sarwoko Kaniza Wibisono , Rianto Syafarina Tiyani , Kakiay Jessica Elisabeth
Published: November 2022

This Nike ad ‘What will they say about you?’ version, focus on female athletes who wear hijab so that they can carry out sports activities comfortably and do not need to think about the opinions of those around them who think that women wearing hijab are inappropriate to be athletes or do activities that are considered too masculine. This study aims to find and understand the meaning of the Nike ad ‘What will they say about you?’ version, through Roland Barthes's theory of Semiotics. This research used the qualitative interpretative method. The results of the study indicate that in the advertisement there are signs that have meaning directly or indirectly for the audience. Nike wants to show motivation and enthusiasm to all women, especially athletes who wear the hijab or to keep doing the sports they want without having to fear being judged by their social environment. With the tagline used in this advertising campaign, namely "Believe in More", Nike would like to say that, not all views, responses, or opinions against athletes are all bad and negative.
HUBUNGAN ANTARA IKLIM KOMUNIKASI ORGANISASI DENGAN KINERJA KARYAWAN DINAS KOMUNIKASI DAN INFORMATIKA JAWA BARAT
Authors: Rahmadani Syifa Sharifa , Komariah Kokom , Hafiar Hanny
Published: November 2022

In a company, it is vital to understand the organizational climate which affects the achievement of organizational goals. This background encourages researchers to examine the relationship between organizational communication climate and employee performance at the West Java Communication and Information Office. Through a quantitative correlational study with a sample of 62 people. This study aims to determine the relationship between the trust of all members of the organization, joint decision-making, honesty, openness in downward communication, listening in upward communication, and attention to high-performance goals with functional tasks and behavioural tasks of the Java Communications and Informatics Service employees. West. The method used in this research is a quantitative correlational study. The results showed that all aspects of the organizational communication climate, including trust, shared decision making, honesty, openness in downward communication, listening in upward communication, and attention to high-performance goals, were significantly correlated with employee performance, including the following aspects: tasks functional and behavioural tasks. The highest correlation coefficient value is in the honesty aspect, with rs of 0.766. And the lowest correlation coefficient on the aspect of trust with rs of 0.303. The conclusion is that there is a significant relationship with a significant relationship between organizational communication climate and the performance of employees of the West Java Information and Communications Office.
KOMUNIKASI KELOMPOK RECURVE BEREGU PUTRI JAWA TIMUR PADA PEKAN OLAHRAGA NASIONAL XX
Authors: Putranto Teguh Dwi
Published: November 2022

Communication a necessary component of the training process that cannot be ignored until the competition period. Effective communication between fellow athletes during physical training, technical training, and mental training can lead to complete understanding for athletes. Likewise, during a match, when technical, physical, and mental exercise is no longer carried out before the match, communication cannot be ignored during the match. This study aims to determine how the group communication of the East Java women's team archery recurves at the XX National Sports Week (PON) in Papua. The East Java women's team recurve archery was chosen in this study because of the consistent achievement of East Java archery during participation in PON, one of which was in the women's team recurve number. The method used in this study is the semiotics of Charles Sanders Peirce in the final video of the East Java women's team archery competition at the Papua National Sports Week, which was obtained through the Youtube channel "Media Second TV." This study shows that  group communication in the sport of recurve archery for the women's team of East Java at the XX National Sports Week (PON) in Papua is dominated by non-verbal communication during the final match.
Digital platforms and services to transform the education industry
Authors: Yanikova Z. M.
Published: November 2022

The article discusses the prospects for Russia’s digital transformation by 2030. The education industry is mandatory for all regions. Thus, variables necessary to calculate its digital transformation indicators have been identified at the federal level. In all constituent entities of the Russian Federation, there is a demand for digital platforms and services that can ensure the fulfillment of federal requirements taking into account regional specifics. To this end, the article provides a detailed analysis of the variables for calculating digital transformation indicators in the education industry. The analysis was performed using 1C software products. In this regard, the model of the integrated automation of a modern educational institution when delivering the modules of the Digital School project on the 1C:Enterprise development platform is of practical interest to the administrations of Russian educational organizations. Using it will make it possible to digitally transform the education industry. The article thoroughly examines the use of mandatory variables for calculating digital transformation performance indicators at the regional level. Additionally, the research focuses on real automation cases that clearly demonstrate how and with what technologies and 1C services specific educational institutions have addressed their needs.
Proses Berpikir Siswa Diskalkulia dalam Menyelesaikan Soal Cerita Perbandingan Berdasarkan Langkah Polya
Authors: Kusumawaty Millah , Trapsilasiwi Dinawati , Murtikusuma Randi Pratama , Hobri Hobri
Published: November 2022

This research aims to describe dyscalculia students’ thought process in solving comparison word problems based on Polya’s steps. Data analysis was carried out based on written test and interviews. This research was conducted on students grade VIII with dyscalculia at SMP Muhammadiyah 3 Rambipuji, Jember. Instruments used in this research were dyscalcuilia diagnostic test questions, comparison word questions, interview guides, and validation sheets. This research is descriptive with a qualitative approach. Dyscalculia students experienced diequilibrium in every steps of Polya, those are understand the problems, devising a plan, carrying out the plan, and looking back. Dyscalculia students experienced assimilation when they tried to mention what are known and asked in the questions regardless of whether it is true or not, also they triedto determine the ways to solve the problem. Accomodation happended when dyscalculia students could mention what are known and asked in the questions. Dyscalculia students experienced equilibrum when they could understand the problem well. Dyscalculia students experienced assimiliation and accomodation to reache quilibrium phase.
Antioxidants Reduce Microleakage of Resin-based Composite Fillings and the Associated Toxicity After Bleaching Human Teeth
Authors:   Students Research Committee, School of Dentistry, Arak University of Medical Sciences, Arak, Iran., Meshkinnejad Romina , Nakhostin Afrooz ,   Department of Restorative Dentistry, School of Dentistry, Arak University of Medical Sciences, Arak, Iran., Khosraviani Farshad ,   University of California, Los Angeles, School of Dentistry, California, USA.
Published: November 2022

Background: Bleaching teeth is popular because the discoloration is a major people’s concern. This study aimed to compare the effect of three antioxidants on the microleakage of composite resin filling after bleaching teeth with 35% H2O2, thus minimizing the potential clinical toxicity of filling materials entering patients’ body. Methods: Sixty-six extracted intact teeth were included in this study. After preparation of a ClV cavity on the buccal surface, the teeth were randomly divided into six groups (n=11, each). Except for group A (control), all others were bleached. Cavities in group A were filled with composite resin. In group B, the samples were immediately restored after bleaching while in group C, the filling was delayed for two weeks after bleaching. In groups D, E, and F, the cavities were treated with either sodium ascorbate, ascorbic acid, or vitamin C, and the filling restored. Teeth were sectioned and the microleakages examined microscopically, and the data were analyzed statistically. Results: Group A showed the least amount of microleakage. In Group B, there was a significant increase in the microleakage when the samples were filled immediately after bleaching. The microleakages among groups of C, D, E, and F were similar to those in group A. Conclusion: The microleakage increased significantly after bleaching with 35% H2O2, while treating dental cavities with the antioxidants effectively reduced the microleakage. Thus, delayed filling is a useful approach to minimize the microleakage. The findings help reduce or prevent the clinical toxicity arising from the microleakage of filling materials.
Nickel Increases Chromosomal Abnormalities by Interfering With the Initiation of DNA Repair Pathways
Authors:   Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran., Ghorbani Mahsa , Haddad Farhang ,   Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran., Shahrokhabadi Khadijeh ,   Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
Published: November 2022

Background: Nickel is a carcinogenic, heavy metal released through industrial activities and via natural resources. It is able to cause DNA damages by reducing the efficiency of DNA repair mechanisms. However, the exact time point at which it is able to interfere with these mechanisms is not yet clearly understood. Methods: To find the most nickel-vulnerable time of repair mechanisms, human dermal fibroblasts (HDF) were treated with three doses of nickel before and after X-irradiation. The induced frequency of chromosomal abnormality was studied using micronucleus assay in binucleated cells. The cytotoxicity of different treatments was established using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results: The results revealed that nickel treatment had a synergistic effect on inducing Micronucleus frequency only when cells were treated 2 hours before X-irradiation. The X-ray treatment of the cells with 5 and 10 mM nickel had a cytotoxic effect mainly when given 6 hours after the irradiation. Conclusion: The results suggest that nickel can interfere with human DNA repair mechanisms only at the start of the process, while having no significant effect on the human DNA repair mechanisms when activated.
Dexamethasone Promotes the Risk of Cardiovascular Disease in High Fructose-exposed Wistar Rats
Authors:   Animal Physiology Unit, Department of Zoology, University of Ilorin. Ilorin, Nigeria., Abdulkareem Adam Olaitan , Olusegun Abe Emmanuel ,   Animal Physiology Unit, Department of Zoology, University of Ilorin. Ilorin, Nigeria., Aderemi Olatunji Lawrence ,   HOPE Cardiometabolic Research Team, University of Ilorin. Ilorin, Nigeria.
Published: November 2022

Background: Dyslipidemia constitutes a serious public health concern globally. It has been established that excessive fructose intake results in dyslipidemia; however, whether dexamethasone aggravates or alleviates fructose-induced dyslipidemia is unknown. Thus, we examined the effects of dexamethasone on dyslipidemia and hyperuricemia in high fructose-taking Wister rats. Materials and Methods: Twenty male Wister rats were randomly grouped as control (distilled water), fructose (10% fructose w/v), dexamethasone (0.2 mg/kg, PO) and fructose+dexamethasone. After a 21-day exposure, the serum and heart samples were harvested, processed and analyzed for biochemical assays. Results: Our findings reveal that exposure of rats to high fructose significantly increased blood glucose, elevated serum triglycerides and uric acid, activity of xanthine oxidase, and lowered high density lipoprotein cholesterol (HDL) level. However, dexamethasone administration had no significant effect on the blood glucose and did not alter the serum levels of triglycerides, uric acid and xanthine oxidase. Meanwhile, both fructose and dexamethasone treatments independently elevated the serum levels of total cholesterol (TC), low density lipoprotein cholesterol (LDL) and malondialdehyde. Further, the fructose treatment elevated the TG/HDL ratio, while both fructose and dexamethasone treatments individually and synergistically elevated TC/HDL ratio. Our study also showed that co-administration of fructose and dexamethasone aggravated the elevated serum levels of TC and LDL, while it impaired the enzymatic antioxidant systems. Conclusion: Dexamethasone, though slightly reduced fructose-induced hyperglycemia, impaired the antioxidant enzymes and escalated dyslipidemia during fructose intake. Hence, our study suggests that dexamethasone administration may increase the risk of CVD in animals with excessive intake of fructose.
Dependence of crop capacity and grain quality of winter triticale varieties on the level of mineral nutrition and seeding rates
Authors: Torikov V. E. , Melnikova O. V. , Malyavko G. P. , Osipov A. A. , Dornykh G. E. , Sychev S. M.
Published: November 2022

Relevance and methodology. The response of present winter triticale varieties to the nitrogen nutrition level was assessed at different seeding rates in the agro-climatic conditions of the Bryansk region. The research object was a set of new winter triticale varieties cultivated by intensive technology on gray forest tame soils in the Bryansk region.

The purpose of the research was to identify the potential of crop capacity and grain quality of present varieties of winter triticale, depending on the mineral nutrition level and seeding rates. Field experiments were carried out in the educational and experimental farm of the Bryansk State Agrarian University in 2019–2021 with the following crop rotation system: vetch-oats mixture for green fodder, winter triticale, potato, spring wheat.

Results. It was established that the grain yield of the varieties under study largely depended on the conditions of moisture and heat availability in the growing season. In the experiment variant with N168Р96К96 and additional fertilizing of ammonium nitrate and ammonium sulfate at the rates of N24 and N10 during spring vegetation and in the shooting stage, the varieties Tornado, Runo, Nina, Impulse, Tribune, Carnet and Legion were distinguished due to the producing programmed grain yield — from 85 to 100 ctw/ha. The grain yield of the varieties Dynamo, Nemchinovskaya 56, Promet and Valentin was from 83.3 to 84.4 ctw/ha on average. In the experiment years all the varieties under study formed stable yields and grain with a high content of crude protein and gluten. On tame soils, with high rates of mineral fertilizers and tank mix of herbicides, the seeding rates of winter triticale seeds can be reduced to 4.5 and 5.0 mln pcs of germinating seeds per 1 ha, therefore, these agrotechnical techniques can be recommended into production as the most important factor of increase of high-quality grain yield.
The role of grafting in the productivity of tomato of extended cycle
Authors: Voronkova I. R. , Rzaeva V. V.
Published: November 2022

Relevance. The purpose of the research: to study the effect of technological method (grafting) on tomatos productivity in the conditions of protected soil in the Tyumen region. Research objectives: based on the study of tomato rootstocks for the studied graft, to identify the most productive rootstock for subsequent use in LLC “Greenhouse facility “TyumenAgro” . Subject of research: protected ground conditions.

The object of research: tomato hybrids F1 Maxeza, F1 Trovanzo and F1 Complis (as grafts), F1 Maxifort and F1 Emperador (as a rootstocks). The article also provides information on the use of the technological method of grafting when growing tomatoes in protected soil conditions in LLC “Greenhouse facility “TyumenAgro””.

Methods. The productivity of tomatoes is taken into account from1 m2 in three-fold repetition. Crop accounting is carried out separately for each option as the fruit ripens, after 5–7 days. The results of crop accounting are processed by the method of variance analysis presented by B.A. Dospekhov. Results. In the course of research, it was found that the cultivation of tomato hybrids in conditions of lowvolume hydroponics, subject to phytosanitary measures, allows to increase the yield and quality of fruits. The highest yield for the crop cycle of 2018–2021 was observed in plants with Maxesa F1 graft and Emperador F1 rootstock, it amounted to 226.47 kg/m2. Based on the research, elements of a new technology will be proposed, characterized by significantly higher quality indicators of tomato productivity formation.
Study of the effectiveness of a new antifungal agent for the treatment of animal dermatophytosis
Authors: Chernykh T. F. , Lunegov A. M. , Shults A. V. , Lunegova I. V. , Flisyuk E. V.
Published: November 2022

Relevance. Small domestic animals often suffer from dermatophytosis chronically, while remaining active carriers. In clinical medicine, there is a certain arsenal of drugs with antifungal activity, both ofsystemic and local action, the use of which often causes side effects. In this regard, the search, development and implementation in public health and veterinary practice of highly active and low-toxic drugs that can specifically affect pathogenic fungi without adverse effects on the body is relevant. On the basis of screening microbiological studies, a thiadiazole derivative was selected, which in preliminary experiments showed antifungal activity.

Methods. The study was conducted on the basis of the St. Petersburg State Chemical Pharmaceutical University for 21 days. 19 cats in the analyzes of which a fungus Microsporum canis was detectedwere used in the experiment. An ointment based on a thiadiazole derivative was rubbed into the affected area of the skin once a day in an amount of 0.01–0.05. The therapeutic efficacy of ointments was evaluated for 21 days according to the following parameters: specific glow of lesions in the rays of a Wood's lamp in the presence of a pathogen; results ofseeding and microscopic examination of the material; coat recovery time; local irritant action.

Results. When animals were treated with 3% thiadiazole ointment, on the 10–12th day the inflammation regressed, and abundant small-lamellar peeling was observed on the skin in the foci. By 12–15th day the surface of the foci was cleared, and the skin acquired a pale pink color. The restoration of the coat was observed at the end of the application of the ointment — on 21st day. The specific glow of regrown hairs in the rays of the Wood's lamp ceased. The results of seeding and microscopy of regrown hairs became negative. Negative reactions when applying the ointment to the skin of animals were not observed. The results of the study indicate high efficacy and good tolerability of 3% thiadiazole ointment.
The effectiveness of the association of probiotics in the diets of sheep
Authors: Romanov V. N.
Published: November 2022

Relevance. Of scientific interest are studies on the physiological effect of the association of probiotic strains of microorganisms for their subsequent use by ruminants in order to increase productivity due to increasing the adaptive capabilities of the body.

Methods. To study the effect of feeding the association of probiotics in loose and granular species, physiological experiments were conducted on animals with chronic rumen fistulas, with the study of the characteristics of consumption and digestibility of feed nutrients, nitrogen balance, indicators of scar digestion, microbiota of the large intestine, features of metabolic processes in the body and indicators of natural resistance according to generally accepted modern research methods.

Results. The positive effect of feeding the association of probiotics at dosage7 g/head/day in bulk and in mini-granules on feed consumption, digestibilitywas revealed, with an increase in the amount of compound nutrients and an increase in digestibility coefficients, as well as nitrogen retention. Higher levels of mass formation of bacteria, protozoa, their amounts both before and after feeding, with a higher concentration of volatile fatty acids, amylolytic activity were found in the scar content. In microbiological studies of fecesunder the influence of the probiotic association, higher levels of lactobacilli, bifidobacteria were found, with a lower level of lactose-positive non-pathogenic microorganisms belonging to the Escherichia coli group of pathogenic molds, enterococci. The improvement of carbohydrate-fat and protein metabolism, as well as hematological parameters of blood in the body of animals receiving probiotic strains was found. The data obtained indicate the expediency of using probiotic associations in ruminants to improve metabolic processes in the body as a basis for increasing productivity and to improve adaptive capabilities.
The influence of two- or three-breed crossing of young animals of different sexes and directions of productivity on the intake and use of dietary nutrients
Authors: Nikonova E. A. , Yuldashbaev Yu. A. , Kosilov V. I.
Published: November 2022

The aim of the study was to study the effect of crossing dairy cows with bulls of different genotypes on the intake and use of dietary nutrients. It has been established that the leading position in the consumption of all types of nutrients was occupied by three-breed Simmental crossbreeds, which is due to their higher body weight and greater consumption of all types of feed. At the same time, bulls of all genotypes were characterized by the largest intake of nutrients, heifers — bythe smallest, castrated bulls occupied an intermediate position. As a result of the studies, it was found that the efficiency of the digestibility of individual nutrients in the diet of experimental subjects is significantly influenced by the genetic factor. It has been proven that two- or three-breed crossing of Black-and-White cows affects the increase in the efficiency of the use of nutrients in the ration feed.
Opportunities and priorities for the development of the agro-industrial complex of the Bryansk region
Authors: Sychev S. M. , Khramchenkova A. O. , Kuzmitskaya A. A. , Korosteleva O. N. , Polukhin A. A.
Published: November 2022

Relevance. The agricultural sector, including the agro-industrial complex, is currently functioning in difficult socio-economic and geopolitical conditions. The agricultural sector of the economy of the Bryansk region plays a key role in the process of economic development. This article solves the problem of identifying opportunities and identifying priority areas for the development of the regional agroindustrial complex in the conditions of innovative and digital development of the economy.

Methods. A wide range of analytical methods is used in the work: system analysis, program-target and project, statistical method, predictive method. The use of a set of scientific approaches, such as: systemic, interdisciplinary, complex, as well as retrospective and evolutionary, made it possible to carry out a study of the possibilities and priorities of the development of the agroindustrial complex of the region.

Results. The article analyzes the current state of the agroindustrial complex of the region, identifies opportunities and identifies priorities for the development of the most important branches of the agroindustrial complex of the Bryansk region. As a result of the study, it was found that the economic and resource potential of the agroindustrial complex of the region contribute to the development of efficient agricultural production. State support and programs for the development of agriculture have allowed the region to become a competitive leader in a number of positions in the Russian Federation. At the present stage, the Bryansk region fully meets its needs for basic foodstuffs. The necessity of active participation in the development of new investment projects, in the processes of modernization of the main spheres of production and economic activity, the development of possible directions of digitalization is proved. The conclusions drawn from the results of the study are important for practitioners, since they complement the existing knowledge necessary to substantiate the development strategies of the agroindustrial complex and the economy of the country as a whole during the transformation into an innovative digital space.
Innovations in the selection and seed-growing process of grain crops
Authors: Shpilev N. S. , Torikov V. E. , Sychev S. M. , Lebedko L. V. , Sycheva I. V.
Published: November 2022

Relevance. One of the objectively existing factors constraining the effectiveness of creating varieties of self-pollinating cereals is the fact that the selection of valuable genotypes begins from the second hybrid generation and is carried outby phenotype. The phenotype of plants is largely subject to phenotypic and modification variability, which obliges breeders to selectmultiple times. The second factor is the need for a long study of the source material for the reasonable selection of parental forms for hybridization. This process with the use of provocative and infectious backgroundstakes in average 3 years. The use of genomic selection and marker-oriented selection practically removes these restrictions, makes the selection process more manageable and predictable, which significantly reduces the time needed to create varieties and increases the efficiency of breeding.

Methods. The study was carried out by the Konarev electrophoretic method, as well as by the author's methods of reproduction of varieties and of selection in triticale breeding (patent No. 2558255 “Method of reproduction of grain varieties”, patent No. 2127970 “Method of seed selection in triticale breeding”).

Results. The results of hybridization using the best domestic varieties of winter hexaploid triticale as parent forms are presented in order to develop and test new methodological approaches in the selection and seed production of grain crops. The results obtained make it possible to make the process more manageable and predictable, reduce the time needed to create varieties, and, consequently, increase the efficiency of breeding and seed production in agricultural production. The possibility of selecting valuable genotypes from first-generation hybrid plants has been proved.
МЕДІАЦІЯ ЯК СПОСІБ ВИРІШЕННЯ СОЦІАЛЬНИХ КОНФЛІКТІВ
Authors: ЧЕРНЕТА Світлана , КАРПІНСЬКА Наталія
Published: November 2022

Стаття присвячена дослідженню медіації як альтернивного способу вирішення соціальних конфліктів, аналізу Закону України «Про медіацію» в частині вимог щодо статусу та навчання медіатора, розкриттю компетентністного підходу підготовки мабутніх фахівців для надання послуги медіації. Актуалізовано увагу на основних перевегах медіації, як способу вирішення соціальних конфліктів, в умовах війни України з росією. Розкрито поняття компетентності, запропоновано конфліктологічну компетентність медіатора розглядати як сукупність когнітивної (ідентифікація конфдікту), аналітичної (аналіз конфлікту та можливостей інтервенції), біхевіористської (вплив на стилі поведінки в конфлікті), інтервенціоністської (визначення способу та дизайну інтервенції в конфлікт) компетенцій. Сформульовано перелік знань, розумінь та умінь необхідних для формування відповідних компетенцій конфліктологічної компетентності медіатора. Запропоновано внести зміни до чинного Закону України «Про медіацію» в частині законодавчої регламентації переліку обов’язкових компетентностей при підготовці медіатора.
ФЕНОМЕН ВІДПОВІДАЛЬНОГО БАТЬКІВСТВА ЯК ОБ’ЄКТ СОЦІАЛЬНОЇ РОБОТИ
Authors: ЛЕВЧЕНКО Наталія
Published: November 2022

У статті визначено важливість батьківства в розвитку дитини. Узагальнено напрацювання дослідників, які займаються вивченням проблематики соціально-педагогічної та психологічної роботи із сім’ями, формування усвідомленого батьківства і материнства та батьківської компетентності; зауважено, що проблемою репродуктивної праці, розподілу батьківських обов’язків та поєднання професійної зайнятості й материнства займаються закордонні дослідники; батьківства в контексті шлюбно-сімейних відносин; політика держави щодо материнства та батьківства. Проаналізовано різні визначення поняття «відповідальне батьківство»., «батьківство», «усвідомлене батьківство» у законодавчих документах та працях дослідників проблеми; розкрито особливості відповідального батьківства; визначено основні засади відповідального батьківства. Мета статті − проаналізувати феномен відповідального батьківства як об’єкта соціальної роботи. У дослідженні використано методи, аналізу, порівняння та узагальнення наукових джерел із досліджуваної проблеми. Згідно із ст. 51 Конституції України, «сім’я, дитинство, материнство та батьківство охороняються державою», в у статті 50 «Право на батьківство» Сімейного кодексу України зазначено, що «чоловік має право на батьківство». Отже, щасливе дитинство, материнство, батьківство є основою успішної, благополучної, здорової сім’ї. Батьківство здебільшого розуміється дослідниками як особистісне утворення – виховання дітей та комплекс почуттів. Визначено, що відповідальне батьківство − соціально-правовий стан чоловіка, зареєстрованого батьком дитини не тільки від народження, й упродовж усього періоду розвитку дитини; відповідальність батька за свою репродуктивну, батьківську поведінку, за життя і виховання дитини з дотриманням чинних нормативно-правових актів.
Comparing the acceptability of total diet replacement and food-based low energy diets for type 2 diabetes remission amongst South Asians: a public and patient involvement activity
Authors: Farhat Grace , Majeed Sajda , Rutter Martin K. , Issa Basil , Harvie Michelle
Published: November 2022

Background: With type 2 diabetes prevalence rising, low energy diets (total diet replacement and food-based low energy diets) are increasingly used to induce weight loss and achieve diabetes remission. The effectiveness of these diets has been primarily tested in the UK white population but not in the south Asian population at high risk of diabetes. Obtaining the opinion of members of the community on what would constitute a culturally acceptable diet is essential for successful interventions aiming to achieve diabetes remission in south Asians.

Methods: We organised two patient and public involvement activities in the North West of England to understand views of people from the south Asian population on whether low energy diets (850 Kcal) in the form of total diet replacement or food-based meals, are acceptable dietary interventions to achieve type 2 diabetes remission.

Results: Thirteen people, with either type 2 diabetes or having someone with diabetes in the family attended a virtual or a face-to-face meeting. Low energy total diet replacement in the form of soups and shakes was considered unacceptable, while there was a preference for a culturally tailored low energy food-based diet.  Ready-made portion controlled catered meals were suggested as a likely approach to improve adherence.

Conclusions: This work provided valuable insights to shape a future study looking at the feasibility of a catered meal low-energy dietary intervention to induce T2D remission in primary care within the south Asian population.
Determinants of Depression: Implications for African Americans and other populations during the COVID-19 pandemic
Authors: Gerbi Gemechu B , Miles-Richardson Stephanie
Published: November 2022

Objective: To explore the impact of Social Determinants of Health (SDH) on the prevalence of selfreported depression among adults aged ≥18 years in the United States to understand baseline data in advance of an anticipated increase in depression due to the COVID-19 pandemic. Methods: Data were analyzed from the 2017 Behavioral Risk Factor Surveillance System (BRFSS) for adults aged ≥ 18 years. A multivariable logistic regression model was used to estimate the adjusted odds ratios (AORs) and 95% confidence intervals (95% CIs) for factors associated with self-reported depression. All analyses were conducted using SAS version 9.4. Results: The results of the multivariable logistic regression analysis show that females (AOR: 1.80; 95% CI: 1.71-1.87); those with an annual household income of less than $50,000; those who were divorced (AOR= 1.42; 95% CI=1.34-1.51); those who were separated (AOR= 1.41; 95% CI=1.23-1.60); those who were never married (AOR= 1.24; 95% CI=1.16-1.32) and those who perceived their health as poor (AOR= 2.18; 95% CI=2.07-2.30) were significantly more likely to report a history of depression diagnosis. The findings also indicate that feeling unsafe or extremely unsafe in one's neighborhood, not being able to pay bills, and having higher levels of stress were associated with higher odds of reporting a history of depression diagnosis. Conclusion: Three variables of SDH were associated with depression. Since these variables are also impacted due to the COVID-19 pandemic, we can anticipate an increase in depression diagnoses. The results of this study can be used to inform the allocation of resources for depression prevention and treatment.
Методичний підхід щодо уніфікованої оцінки ступеня професійної придатності військовозобов’язаних
Authors: Bodnar Oleh , Pampukha Ihor , Kharabara Volodymyr , Bilyk Oleksandr
Published: November 2022

Мета роботи: Обґрунтувати застосування універсальної вербально-числової шкали Харрінгтона для уніфікації професійного відбору резервістів на посади відповідно до ВОС та розробки вирішального правила оцінки професійної придатності.

Метод: використані загальнонаукові методи  аналізу та синтезу.

Теоретична цінність дослідження: основними результатами дослідження за тематикою статті є уніфікація оцінки ступеня професійної придатності військовозобов’язаних, яка полягає у заміні різнорідних вимірювальних шкал універсальною шкалою, на якій кількісні значення будь-яких особистих якостей поєднані з його якісною оцінкою та допускається аналітична згортка різних параметрів в узагальнений показник професійної придатності військовозобов’язаного.

Практична цінність дослідження: запропонований методичний підхід дозволяє оцінити рівень придатності військовозобов’язаного за кожним показником особистих якостей.

Цінність дослідження: використовуючи зазначену методику, суб’єкти які відповідають за відбір та призначення військовозобов’язаних на посади за відповідною ВОС отримують можливість провести необхідні числові розрахунки та надати обґрунтовані пропозиції керівникам військових організаційних структур що до подальшого прийняття кадрового рішення.
Anticipate Your Next Move in Chronic Myeloid Leukaemia Patient Management
Authors: Feys Tom
Published: November 2022

Treatment decisions in chronic myeloid leukaemia (CML) are complex and require the evaluation of many factors at each stage of therapy. Many patients will become resistant or intolerant to the first and subsequent lines of tyrosine kinase inhibitors (TKI) they receive, requiring them to switch to a different TKI. Clinicians are faced with many considerations when choosing subsequent treatments and an important issue is how best to manage failure on a second-generation TKI. During an interactive and case-based, Incyte-sponsored, satellite symposium at the 2019 European Hematology Association (EHA) congress, Dr Janssen and Prof Apperley discussed the current best practices for managing patients failing imatinib or second-generation TKI, considering whether second-generation TKI should be used sequentially and the timing of the introduction of a third-generation TKI (ponatinib). Dr Soverini and Dr de Lavallade discussed how regular BCR-ABL response monitoring and mutational analysis are integral to CML patient management. They highlighted the clinical relevance of low-level mutations and the necessity to prevent clonal expansion of these TKI-resistant mutants, and the accumulation of additional mutations, by switching to an effective TKI in a timely manner.
Infliximab and Tumour Necrosis Factor Alpha Measurement on Intestinal Mucosa: A New Tool for the Clinic?
Authors: Pecere Silvia , Petito Valentina , Amato Arianna , Poscia Andrea , Armuzzi Alessandro , Lopetuso Loris Riccardo , Sgambato Alessandro , Cammarota Giovanni , Papa Alfredo , Gasbarrini Antonio , Scaldaferri Franco
Published: November 2022

Background: Infliximab (IFX) trough levels measurement could partially explain mechanisms of loss in response to this drug. However, little information exists on its concentration at the mucosal level or mucosal pharmacokinetics.

Objective: The aim of this study was to investigate whether IFX could be measured within intestinal mucosa, and whether a correlation between mucosal level, serum level, and clinical response could be hypothesised.

Methods: Fifteen consecutive patients with inflammatory bowel disease receiving stable doses of IFX who underwent endoscopy were enrolled. Biopsies were taken from an affected and an unaffected area and cultured for 48 hours, and serum samples were also collected. IFX and tumour necrosis factor alpha (TNF-α) levels were measured using commercially available enzyme-linked immunosorbent assay kits.

Results: IFX levels were detected in 80% of the colonic biopsy supernatants and in 60% of the serum samples. TNF-α intestinal mucosal levels were detectable in 100% of patients, while TNF-α serum levels were detectable in 75%. Mucosal and serum levels of IFX and TNF-α did not correlate; no correlation was found between the last infusion and serum or intestinal mucosal levels. Levels of IFX were more frequently undetectable in the mucosa of patients not responding to IFX therapy.

Conclusions: Detectable levels of IFX and TNF-α can be found in intestinal mucosa. IFX mucosa levels could be useful to stratify patients into responders and non-responders to IXF therapy.
Manejo de la Enfermedad Hemorroidal
Authors: Legg Ewen
Published: November 2022

Este seminario especializado financiado mediante una contribución independiente realizada por OM/Vifor Pharma reunió a facultativos especializados en cirugía vascular, ginecología y dermatología de Pakistán, Egipto, Turquía, Líbano y Alemania para debatir acerca del manejo actual de la enfermedad venosa crónica y la enfermedad hemorroidal (EH). El seminario estuvo compuesto de presentaciones plenarias y debates interactivos sobre estudios de casos, permitiéndose a delegados y ponentes participar en discusiones de mayor nivel sobre cuestiones candentes en este campo.