bluuebunny/crossref_metadata_2025 huggingface dataset:
Pecan Shell Mulch Impact on ‘Loring’ Peach Tree Establishment and First Harvest
Authors: Stafne Eric T. , Rohla Charles T. , Carroll Becky L.
Published: August 2023

Pecan (Carya illinoinensis) shells are waste products that are occasionally used for mulch in ornamental landscape settings, yet most shell waste is left in piles near the shelling facility or discarded by other methods. If another use for this waste product could be developed, it may add income for pecan producers and provide peach (Prunus persica) growers with another option for weed control. A block of ‘Loring’ peach trees grafted onto ‘Halford’ rootstocks was planted at a spacing of 18 × 22 ft in Feb. 2005 at the Cimarron Valley Research Station near Perkins, OK, to determine the effect of pecan shell mulch on peach trees. Five treatments were imposed: no weed control except mowing (MOW), weed-free 6- × 6-ft area maintained with glyphosate herbicide (SPRAY), 6-ft × 6-ft × 2-inch deep mulch (TWO), 6-ft × 6-ft × 4-inch deep mulch (FOUR), and 6-ft × 6-ft × 6-inch deep mulch (SIX). Yields in 2008 were poorest in the MOW treatment (13.2 kg/tree and 93 fruit/tree). All other treatments did not differ. Soluble solids concentration as a measure of fruit quality and fruit weight was unaffected by treatment. Tree height, pruning weights, and trunk cross-sectional area were similar with the exception that MOW was lower for all three growth measurements beginning in 2007. Pecan mulch appears to have the potential to reduce soil pH. Foliar analysis for nitrogen (N), potassium (K), and zinc (Zn) showed treatment differences in 2006. No treatment differences were evident in 2007 and 2008 for K and Zn, but in 2008, FOUR had greater N than MOW. Tree mortality increased with pecan mulch depth. MOW, SPRAY, and TWO had little tree loss (0%–5%), whereas FOUR and SIX had 15% and 35% mortality, respectively. Tree mortality was attributed to record rains in 2007 coupled with longer soil moisture retention under the deeper mulch.
Bloom and Harvest Dates, Fruit Quality Attributes, and Yield of Modern Peach Cultivars in the Intermountain Western United States
Authors: Fallahi Esmaeil , Fallahi Bahar , Shafii Bahman , Amiri Mohammad E.
Published: August 2023

Production of peaches (Prunus persica) in southwestern Idaho and other states in the intermountain western United States has increased during recent years, requiring information on the performance of modern cultivars in the region. Thus, a long-term project was conducted to investigate bloom date, harvest date, cumulative growing degree-days, fruit quality, and yield of various yellow- and white-fleshed peaches under conditions of southwestern Idaho during 2003 to 2007. The analysis of average response over these years indicated that ‘Snow Giant’, ‘Jupiter’, ‘Yuko King’, ‘Burpeach Six’, ‘Fairtime’, ‘Coral Star’, ‘July Sun’, and ‘Zee Lady’ bloomed earlier (5–7 Apr.), while ‘Sierra Gem’, ‘Fancy Lady’, and ‘Red Star’ bloomed later (11–12 Apr.) than other cultivars. ‘Crimson Lady’, ‘May Sun’, and ‘Sierra Gem’ were the earliest cultivars, had smaller fruit, and on average were harvested on 11, 13, and 24 July and needed 94, 96, and 103 days from full bloom to harvest, respectively. ‘Opal Moncav’, ‘August Flame’, ‘August Lady’, ‘Ryan Sun’, ‘September Snow’, ‘Yukon King’, and ‘Fairtime’ were harvested during the second half of September. The periods between bloom and harvest for these cultivars on average were 160, 163, 163, 168, 171, 173, and 177 days, respectively, and these cultivars often had greater soluble solids concentrations than other cultivars. ‘PF12B’ and ‘PF15A’ were “mid-season,” but ‘PF 20–007’ and ‘PF 24–007’ were “late-season” cultivars. ‘PF12B’, ‘PF15A’, ‘PF 20–007’, ‘Star Fire’, ‘Burapeach Six’, ‘Coral Star’, ‘All Star’, and ‘Zee Lady’ had higher yield than many of the other cultivars. While the “early-season” cultivars can be planted for regional and local market, the “mid-season” and “late-season” peaches are excellent choices for marketing during September and early October when production of the similar cultivars are already completed in warmer regions. Overall, ‘Sweet Dream’, ‘August Lady’, ‘Zee Lady’, ‘August Flame’, ‘Snow Giant’, ‘Saturn’, ‘Jupiter’, and ‘PF24–007’ showed satisfactory to great performance in this long-term evaluation.
PHYSICOCHEMICAL ASPECTS OF INDUSTRIAL PLANT-BASED BEVERAGES
Authors: Francisquini Júlia , Altivo Ramon , Diaz Cristian , da Costa Juliana , Kharfan Daniela , Stephani Rodrigo , Perrone Ítalo
Published: August 2023

The variety of vegetables available for plant-based beverage production is associated with a lack of specific regulatory aspects and difficult standardization. The aim of this study was to characterize the physicochemical properties of plant-based beverages (five different sources, three different market brands for each vegetable). The parameters studied were pH, moisture content, acidity, soluble ionic calcium at initial pH and pH 4.3, soluble solids, heat coagulation time (HCT), density, conductivity, surface zeta potential, morphology, polydispersity index, particle size. When comparing the mean values of the results found in the present work with model emulsions and/or plant based beverages produced on a laboratory scale, it can be found that the mean values for pH, moisture, soluble solids, calcium, surface zeta potential, particle size, and polydispersity index were similar to the reported values in the literature, however, acidity, HCT, density, and conductivity were lower than those reported in the literature. The coconut plantbased beverage exhibited the most significant statistical difference as compared to other plant-based beverages, especially in terms of pH, conductivity, particle size, and polydispersity index. This study is a promising aid to regulatory agencies and industries for standardization of nutritional value, production, stability, storage and chemical attributes of these beverages.
Live Weight, Fleece Yield and Quality after Shearing in Hamdani and Karakaş Sheep
Authors: BİNGÖL Erdal , BİNGÖL Mehmet , GÜLER Ayhan , DEMİR Ferhat
Published: August 2023

This study was carried out to determine some wool yield characteristics and post-shearing live weight of 35 head Hamdani and 40 head Karakaş sheep reared in fully extensive conditions in Central Budakli village of Hakkari province.In the study, the results for length (Hauter), length (Barbie), elasticity, fineness, strength, clean fleece percentage, greasy fleece weight and post-shearing live weight were found to be; 42.38 mm-40.51 mm-, 58.25 mm-54.64 mm, 32.34%-32.31%, 36.64 μ-37.62 μ, 36.15 cN tex -34.80 cN tex, 63.88%-65.94%, 2.12 kg-1.84 kg and 60.33 kg-48.55 kg respectively in Hamdani and Karakaş ewes.In Hamdani sheep, the correlation between elasticity and strength (0.499) and between greasy fleece weight and post-shearing live weight (0.599) was very significant (p
Farklı Dönemlerde Hasat Edilen Maralfa (Miscanthus gigantus) Otunun Yem Değeri Özelliklerinin Belirlenmesi
Authors: BİLAL Yakup , BAKIR Tuğba , SELÇUK Bilal , AKÇAM Hülya , ATALAY Ali İhsan
Published: August 2023

Bu araştırmada farklı dönemlerde hasat edilen maralfa (Miscanthus gigantus) otunun kimyasal kompozisyonları, gaz ve metan üretimleri, metabolik enerji değerleri (ME), organik madde sindirim dereceleri (OMSD), gerçek sindirilebilir kuru madde (GSKM), mikrobiyal protein (MP), partitioning factor (PF), mikrobiyal protein sentezleme etkinliği (MPSE) ve nispi yem değerleri (NYD) belirlenmiştir. Maralfa otunun hasat dönemlerinin kimyasal kompozisyon bakımından önemli farklılıklar tespit edilmiştir (P
Glutenli ve Glutensiz Bisküvilerin Kestane, Lüpen ve Balkabağı Unlarından Hazırlanan Kompozit Un ile Zenginleştirilmesi
Authors: CANKURTARAN KÖMÜRCÜ Tekmile , BİLGİÇLİ Nermin
Published: August 2023

Bu çalışmada, kestane (Castanea sativa), lüpen (Lupinus albus) ve balkabağı (Cucurbita moschata) unlarının eşit oranda birleştirilmesiyle elde edilen kompozit un atıştırmalık ürünleri çeşitlendirmek ve geliştirmek için glutenli ve glutensiz bisküvi formülasyonunda kullanılmıştır. Kompozit un glutenli bisküvilerde buğday unu ile, glutensiz bisküvilerde ise mısır nişastası:pirinç unu karışımı ile %12, 24, 36 ve 48 oranlarında yer değiştirilerek kullanılmış ve bisküviler fiziksel, kimyasal ve duyusal özellikler açısından değerlendirilmiştir. Artan oranda kompozit un kullanımı ile her iki bisküvi çeşidinde de L* değeri azalırken, a* ve b* değerleri artış göstermiştir. Glutenli bisküvilerin yayılma oranı %36-48 kompozit un kullanımı ile düşmüştür. %12 ve üzeri kompozit un kullanım oranlarında glutenli ve glutensiz bisküvilerin sertlikleri artmıştır. Kontrol bisküvi örnekleri ile karşılaştırıldığında, bisküvi formülasyonlarında %48 oranında kompozit un kullanımı ile protein ve antioksidan aktivite değerleri glutensiz örneklerde sırasıyla 2.4 ve 2.5 kat artış sağlarken, glutenli bisküvi örneklerinde sırasıyla 1.4 ve 2.6 kat artış göstermiştir. Kompozit unun en düşük kullanım oranı bile hem glutenli hem de glutensiz bisküvilerin Ca, K, Mg, Mn ve P miktarında artış sağlamıştır. Kompozit unun %12 kullanım oranı ile her iki bisküvi çeşidinde de en yüksek genel kabul edilebilirlik değerleri elde edilmiştir.
Pamuk Bitkisi Üretim Alanı Ortam Nem ve Sıcaklık Değerlerinin, SAR ve Optik Uydu Görüntüleri ile Tahmin Edebilirliğinin Araştırılması
Authors: KILIÇASLAN Serkan , EKİNCİ Remzi , ARSLANOGLU Mehmet Cengiz
Published: August 2023

Mardin İli Artuklu ve Kızıltepe İlçelerine bağlı 8 adet köy ve 27 adet pamuk parselinde yürütülen çalışmada, arazilerde ortam nem ve sıcaklık değerleri, 6 saat aralıklar ile datalogger cihazları ile ölçülmüş ve kayıt altına alınmıştır. Data loggerlardan elde edilen veriler, Google Earth Engine (GEE) ortamında hazırlanan Sentinel-1 ve Landsat-8 uydu verileriyle analiz edilerek aralarındaki ilişki irdelenmiştir. Ortam nemi (ON) değerleri ile VV (R2=0.63), VV-VH (R2=0.68), Toprak Nem İndeksi (SMI) (R2=0.84) arasında yüksek ilişki saptanırken, VH (R2=0.05), LEE_VH (R2=0.07), LEE_VV (R2=0.56), GAMMA_VH (R2=0.09), GAMMA_VV (R2=0.50), MALIK_VH (R2=0.07), MALIK_VV (R2=0.57) ve Arazi Yüzey Sıcaklığı (LST) (R2=0.35) arasında düşük ilişki saptanmıştır. Ortam sıcaklığı (OS) değerleri ile LST (R2=0.80**) arasında yüksek ilişki saptanırken, VV (R2=0.51), VH (R2=0.06), VV-VH (R2=0.49), LEE_VH (R2=0.09), LEE_VV (R2=0.49), GAMMA_VH (R2=0.11, GAMMA_VV (R2=0.08), MALIK_VH (R2=0.08), MALIK_VV (R2=0.49) ve SMI (R2=0.50) arasında düşük ilişki saptanmıştır. Geniş ölçekli arazi çalışmalarında ortam nemi değerlerinin tahmin edilmesinde VV, VV-VH ve SMI indisi; ortam sıcaklığı değerlerinin tahmin edilmesinde LST bandı yüksek doğruluk ile kullanılabileceği sonucuna varıldığından tavsiye edilmiştir.
Perovskite Güneş Hücreleri İçin EMIMBF4 İyonik Sıvı Katkılı SnO2 Elektron Transfer Tabakasının Düşük Sıcaklıkta Üretimi ve Optimizasyonu
Authors: EBİÇ Murat
Published: August 2023

Yüksek performansa sahip perovskite güneş hücreleri (PSC)’nin elde edilebilmesi için elektron transfer tabakası (ETL) oldukça hayati öneme sahiptir. Bu durum yüksek sıcaklıkta üretilen, uygun enerji bandı hizalamasına ve yüksek optik geçirgenlik ile yüksek taşıyıcı hareketliliğine sahip kalay oksit (SnO2) ETL'nın üretilebilmesiyle mümkün olabilmektedir. Düşük sıcaklıkta üretilen ETL’nda genellikle düşük kristalleşme, zayıf elektron hareketliliği ve tane sınırlarında bol miktarda kusur meydana gelmektedir. Bu da verimli yük taşınmasını engelleyerek, rekombinasyon oluşturmakta ve ciddi enerji kayıplarına sebep olmaktadır. Bu çalışmada düşük sıcaklıkta SnO2 ETL üretiminden kaynaklanan bu olumsuz özellikleri iyileştirmek amacıyla SnO2 ETL içerisine 1-etil-3-metilimidazolyum tetrafloroborat (EMIMBF4) iyonik sıvı (IL)’sı farklı konsantrasyonlarda katkılanarak döndürerek kaplama (spin-coater) tekniği ile düşük sıcaklıkta (100 °C) hazırlanmıştır. EMIMBF4 IL katkılı SnO2 ETL ve perovskite filmlerin optik özellikleri UV-vis-NIR spektrometresi ve fotolüminesans spektrofotometresi (PL) ölçümü kullanılarak araştırılmıştır. Üretilen filmlerin alan emisyonlu taramalı elektron mikroskobu (FE-SEM) ve atomik kuvvet mikroskobu (AFM) ile yüzey morfolojisi incelenmiştir. Filmlerin kristal yapı analizi ise X-ışını kırınımı (XRD) ile gerçekleştirilmiştir. Temas açısı ölçümü kullanılarak yüzeylerin hidrofilik/hidrofobik davranışları değerlendirilmiştir. EMIMBF4 katkılı SnO2 ETL filmlerin saf SnO2 ETL filme göre yüzey kusurlarının pasivize edilerek daha az yüzey kusurlarına sahip oldukları ve nispeten daha düşük ve ekonomik bir sıcaklık da (100°C) kristalleştikleri görülmüştür. %0.5 EMIMBF4 katkılı filmlerin düşük de olsa diğer katkılı ve saf ETL filmlere göre daha iyi optik ve yapısal sonuçlar verdiği tespit edilmiştir.
Evaluating the Effectiveness of Different Machine Learning Approaches for Sentiment Classification
Authors: BAYAT Seda , IŞIK Gültekin
Published: August 2023

This study presents a comparison of four different machine learning algorithms for sentiment analysis on a small subset of the AR-P (Amazon Reviews - Polarity) dataset. The algorithms evaluated are multilayer perceptron (MLP), Naive Bayes, Decision Tree, and Transformer architectures. The results show that the Transformer-based DistilBERT model performed the best with an accuracy rate of 96.10%, while MLP had a better performance than the other remaining methods. Confusion matrices and ROC curves are provided to illustrate the results, and a comparison with previous studies is presented. The study concludes that the results can serve as a basis for future work, such as using larger datasets or comparing the performance of algorithms on different tasks. Overall, this study provides insights into the use of traditional machine learning and modern deep learning methods for sentiment analysis and their potential applications in real-world scenarios.
Overexpression of SOCS2 Inhibits EMT and M2 Macrophage Polarization
in Cervical Cancer via IL-6/JAK2/STAT3 Pathway
Authors: Li Dan , Huang Yandan , Wei Min , Chen Bin , Lu Yan
Published: August 2023

Objective:

SOCS2 is a member of the suppressor of cytokine signaling (SOCS) protein
family associated with the occurrence and development of multiple cancers. This study revealed
the expression and molecular mechanisms of SOCS2 in cervical cancer.

Methods:

In this study, RT-qPCR, Western Blot, and immunohistochemistry were used to detect
the expression level of SOCS2 in cervical cancer tissues and tumor cells. We overexpressed
SOCS2 in SiHa cells via lentivirus. In-vitro experiments were used to investigate the changes in
cervical cancer cell proliferation, migration, and invasion ability before and after SOCS2 overexpression.
Western Blot was used to detect the expression of IL-6/JAK2/STAT3 pathway and EMTrelated
proteins. M0 macrophages were co-cultured with the tumor-conditioned medium. The
effect of SOCS2 on macrophage polarization was examined by RT-qPCR.

Results:

SOCS2 expression level was significantly downregulated in cervical cancer tissues.
SOCS2 was negatively correlated with CD163+M2 macrophages. Overexpression of SOCS2 inhibited
the proliferation, migration, and invasion of cervical cancer cells. The expressions of Twist-
2, N-cadherin, and Vimentin were decreased, while the expression of E-cadherin was increased.
Moreover, the expression of IL-6, p-JAK2, and p-STAT3 were decreased. After the addition of
RhIL-6, the expression of E-cadherin protein in the LV-SOCS2 group was reversed. CM in the
LV-SOCS2 group inhibited the polarization of M2 macrophages.

Conclusion:

SOCS2 acts as a novel biological target and suppressor of cervical cancer through IL-
6/JAK2/STAT3 pathway.
One-pot Synthesis of 2,3-disubstituted-4(3H)-quinazolinone from o-aminobenzoic Acid and DMF Derivatives using Imidazole Hydrochloride as a Promoter
Authors: Wang Yin , Zhang Xiuyu , Li Suzhen , Guo Mengyi , Ma Wanqian , Yuan Jianyong
Published: August 2023

As a novel and environmentally friendly Brönsted acid, imidazole hydrochloride was used to promote the synthesis of 2,3-disubstituted-4(3H)-quinazolinone from o-aminobenzoic acid and DMF derivatives. The essence of this reaction is a multicomponent reaction, which constructs multiple chemical bonds between different components through the transamidation of imidazole hydrochloride. This protocol showed a wide range of functional group tolerance, and a series of quinazolinones were synthesized in low to moderate yields without metal catalysts, oxidants or other additives.
Unearthing Insights into Metabolic Syndrome by Linking Drugs, Targets,
and Gene Expressions Using Similarity Measures and Graph Theory
Authors: epub Alwaz , Wajid Bilal , Shabbir Ans , Gohar Awan Fahim , Ahsan Momina , Ahmad Sarfraz , Wajid Imran , Anwar Faria , Mazhar Fazeelat
Published: August 2023

Aims and Objectives:

Metabolic syndrome (MetS) is a group of metabolic disorders
that includes obesity in combination with at least any two of the following conditions, i.e., insulin
resistance, high blood pressure, low HDL cholesterol, and high triglycerides level. Treatment of
this syndrome is challenging because of the multiple interlinked factors that lead to increased
risks of type-2 diabetes and cardiovascular diseases. This study aims to conduct extensive insilico
analysis to (i) find central genes that play a pivotal role in MetS and (ii) propose suitable
drugs for therapy. Our objective is to first create a drug-disease network and then identify novel
genes in the drug-disease network with strong associations to drug targets, which can help in increasing
the therapeutical effects of different drugs. In the future, these novel genes can be used to
calculate drug synergy and propose new drugs for the effective treatment of MetS.

Methods:

For this purpose, we (i) investigated associated drugs and pathways for MetS, (ii) employed
eight different similarity measures to construct eight gene regulatory networks, (iii) chose
an optimal network, where a maximum number of drug targets were central, (iv) determined central
genes exhibiting strong associations with these drug targets and associated disease-causing
pathways, and lastly (v) employed these candidate genes to propose suitable drugs.

Results:

Our results indicated (i) a novel drug-disease network complex, with (ii) novel genes
associated with MetS.

Conclusion:

Our developed drug-disease network complex closely represents MetS with associated
novel findings and markers for an improved understanding of the disease and suggested therapy.
Unveiling the Anti-convulsant Potential of Novel Series of 1,2,4-Triazine-
6H-Indolo[2,3-b]quinoline Derivatives: In Silico Molecular Docking, ADMET,
DFT, and Molecular Dynamics Exploration
Authors: Singh Hariram , Pathak Devender
Published: August 2023

Background:

Epilepsy is a chronic neurological disorder caused by irregular electrical
activity in the brain. To manage this disorder effectively, it is imperative to identify potential
pharmacological targets and to understand the pathophysiology of epilepsy in depth.

Objective:

This research aimed to identify promising leads from a library of 1,2,4-triazine-6Hindolo[
2,3-b]quinoline derivatives and optimize them using in silico and dynamic processes.

Methods:

We used computational studies to examine 1,2,4-Triazine-6H-indolo[2,3-b]quinoline
derivatives. Some methods were used to strengthen the stability of binding sites, including Docking,
ADMET, IFD, MMGBSA, Density Functional Theory (DFT), and Molecular Dynamics.

Results:

HRSN24 and HRSN34 exhibited promising pharmacokinetic and pharmacodynamic
characteristics compared to standard drugs (Carbamazepine and Phenytoin) and a co-crystal ligand
(Diazepam). Both HRSN24 and HRSN34 presented notable Glide Xp docking scores (-4.528
and -4.633 Kcal/mol), IFD scores (-702.22 and -700.3 Kcal/mol), and MMGBSA scores (-45.71
and -14.46 Kcal/mol). HRSN24 was selected for molecular dynamics and DFT analysis. During
MD, HRSN24 identified LYS21, GLY22, ASP24, ARG26, VAL53, MET55, and SER308 as the
most important amino acid residues for hydrophobic interactions. A DFT computation was performed
to determine the physicochemical properties of HRSN24, revealing a total energy of
-1362.28 atomic units, a HOMO value of -0.20186, and a LUMO value of -0.01915.

Conclusion:

Based on computational modelling techniques, an array of 1,2,4-triazine-6H-indolo
[2,3-b]quinoline derivatives were evaluated for their anti-convulsant properties. A stable compound
within the GABAA receptor was identified by HRSN24, suggesting its affinity as an anti-convulsant.
Evaluation of High-dose versus Standard-dose of Dexamethasone on
Mortality among the Mechanically Ventilated COVID-19 Patients
Authors: Kale-Pradhan Pramodini B. , Pacitto Regina , Giuliano Christopher A. , Johnson Leonard B.
Published: August 2023

Introduction:

Anti-inflammatory agents like dexamethasone (DEX) are a mainstay of treatment for COVID-19. Despite randomized trials demonstrating that a 6 mg daily dose of DEX improved patient outcomes in hospitalized COVID-19 patients receiving oxygen, clinicians often prescribe higher doses of corticosteroids without evidence to support this practice. The purpose of this study was to compare outcomes of ventilated COVID-19 patients who received standard dose (SD) versus high dose (HD) DEX.

Method:

This was a multi-site, retrospective, observational study on ventilated COVID-19-positive patients who received DEX for at least three days between June 1, 2020, and January 31, 2022. The primary outcome of this study was the association between mortality and SD (<6mg daily) versus HD (>10mg daily) DEX in ventilated COVID-19 patients. Secondary outcomes included average blood glucose (BG), number of BG readings above 200, incidence of bacterial nosocomial infection, ventilator-free days, length of stay (LOS), and ICU LOS.

Results:

Of the 212 included patients, 53 (25%) received SD DEX, and 159 (75%) received HD DEX. There was no significant effect of DEX dose on mortality, number of BG readings >200, incidence of nosocomial infections, LOS, or ventilator-free days (p >0.05). After controlling for confounding factors, no difference in mortality persisted (OR 1.34 95% CI 0.62- 2.90). Average daily BG and ICU LOS were significantly greater in the HD group compared to the SD group (p = 0.003, p = 0.019, respectively).

Conclusion:

There was no association between HD DEX and mortality among ventilated COVID-19 patients compared to SD DEX. Moreover, HD DEX is associated with detrimental effects such as prolonged ICU LOS and higher average daily BG. This study supports the use of SD DEX in ventilated COVID-19 patients.
Quercetin-based Nanoformulation: A Potential Approach for Cancer Treatment
Authors: Shivani  , Singh Gurvirender , Narwal Smita , Chopra Bhawna , Dhingra Ashwani K.
Published: August 2023

Nanoformulations derived from natural products are gaining popularity as a treatment option for several human diseases, including cancer, as they offer a viable alternative to conventional cancer therapies, which are often associated with numerous side effects and complications. Quercetin (Que), a plant-derived phenolic molecule, has demonstrated potential as a chemotherapeutic agent for different types of cancer. However, Que's low water solubility, instability towards antioxidants, low bioavailability, and severe biotransformation constraints make it challenging to use in vivo. Nanoparticles have emerged as a promising technology for the precise targeting of tumor cells, leading to improved efficacy and specificity in cancer therapies. In this review, the impact of flavonoid nanoformulations on enhancing the safety, therapeutic potential, and bioavailability of Que in cancer treatment is highlighted. A variety of nanoparticle types have been developed, including polymeric micelles, liposomes, PLGA nanoparticles, coencapsulation, chitosan NPs, lipid carriers, silver and gold NPs, inorganic NPs, organic metal frameworks, and biomacromolecule- based NPs, all aimed at improving the antineoplastic efficacy of Que. These nanoparticles offer several advantages, including prolonged circulation time, tumor-specific biodistribution, high encapsulation efficiency, enhanced therapeutic efficacy, and controlled release. This review provides fresh insights into the arena of drug discovery for tumor therapies by focusing on the influence of flavonoid nanoformulations on the enhancement of their safety, therapeutic, and bioavailability characteristics.
Differential Kat3 Coactivator Usage Regulates Brain Metabolism and Neuronal
Differentiation
Authors: Poku Erasmus Kofi , Ono Masaya , Higuchi Yusuke , Chea Junie , Melendez Elizabeth , Teo Jia-Ling , Nguyen Cu , Chimge Nyam-Osor , Kahn Michael
Published: August 2023

Introduction:

Our previous work has demonstrated significant effects on the oxidative stress response, mitochondrial function, and oxidative phosphorylation in the livers and intestines of p300 S89A knockin (S89AKI) mice. We now show that this mutation is also associated with brain metabolic defects and neuronal differentiation.

Methods:

p300 S89A edited P19 cells, and S89AKI mice demonstrated metabolic and neuronal differentiation defects based on proteomic, cell biological and PET imaging studies.

Results:

The metabolic and differentiation defects associated with the p300 S89A knockin mutation could be corrected both in vitro and in vivo utilizing the small molecule CBP/beta-catenin antagonist ICG-001.

Conclusion:

Rebalancing the equilibrium between CBP/β-catenin versus p300/β-catenin associated transcription, utilizing the small molecule CBP/beta-catenin antagonist ICG-001, enhances mitochondrial oxidative phosphorylation, metabolic function, and neuronal differentiation and may be able to ameliorate the cognitive decline seen in neurodegenerative disorders, including Alzheimer’s Disease.
PENAMPILAN PRODUKSI DAN STATUS NUTRISI KAMBING PERANAKAN ETAWAH (PE) DENGAN PENAMBAHAN TEPUNG BIJI KURMA
Authors: Kuswati Kuswati , Susilorini Tri Eko , Mashudi Mashudi
Published: August 2023

Kambing merupakan sumber daging dan susu di banyak negara berkembang, karena kemampuannya untuk bertahan hidup dan tumbuh di bawah lingkungan iklim yang keras dibandingkan ruminansia lainnya. Fenomena ini memudahkan beternak kambing tanpa fasilitas yang canggih dan kebutuhan nutrisinya dapat dipenuhi dari berbagai jenis pakan atau padang penggembalaan yang tersedia. Tujuan utama dari penelitian ini adalah untuk mengevaluasi pengaruh penambahan biji kurma dalam pakan konsentrat terhadap rata-rata pertambahan bobot badan harian dan status gizi kambing Peranakan Etawah. Dua puluh ekor kambing dipilih secara acak dan didistribusikan ke dalam empat perlakuan masing-masing 5 ekor kambing. Kambing diberi pakan hijauan 60% Pennisetum purpureum dan 40% pakan konsentrat yang mengandung 0; 7.5; 15 dan 22,5% tepung bijiÂ  kurma. Terdapat pengaruh yang nyata (P<0,05) terhadap rata-rata pertambahan bobot badan harian, pakan konsentrat yang mengandung 22,5% lebih tinggi dibandingkan dengan pakan yang mengandung 7,5 dan 15% tepung biji kurma. Disimpulkan bahwa penambahan tepung biji kurma pada pakan konsentrat pada ransum kambing peranakan Etawah tidak menunjukkan efek yang merugikan status gizi, tetapi dapat meningkatkan kinerja pertumbuhan.
POTENTIAL TRIGONA BEEKEEPING (Heterotrigona itama and Geniotrigona thoracica) AT SOUTH LABUHANBATU CITY, NORTH SUMATERA PROVINCE, INDONESIA
Authors: Pinandita Eggi Pur , Minarti Sri , Junus Mochammad , Radiati Lilik Eka , Besari Ratna Iffany F , Soen Jopie Meiske , Simanjuntak Aurora Ivana Br
Published: August 2023

Study area this research was conducted on November 12th â€“ 21st, 2021, located in Kota Pinang, South Labuhanbatu, North Sumatra, Indonesia. The results of this study can provide a report on the results of the analytical test carried out in the laboratory of the University of Brawijaya. South Labuhanbatu Regency is geographically located at 1Â°26'00'' - 2015'55'' North Latitude. 99Â°40'00'' - 100Â°26'00'' East Longitude. Generally, South Labuhanbatu Regency is located at an altitude below 100 meters above sea level. The type of research is exploratory research. The result and discussion gave the best replacement of water content in honey at Apis dorsata as an average of 27%. It showed that the higher the water content and acidity of the honey will explain the lower the quality of the honey. The best replacement levels of sucrose in honey at Heterotrigona itama as an average of 68.5%. The percentage level of sucrose showed that honey with a moisture content of more than 17%, with a total sugar content of <83% is susceptible to cosmetological yeast fermentation. The best pH of Honey placed at Apis dorsata is an average of 2.350 (Acid). The data showed that the low pH value and high acidity can increase the shelf life of honey because it does not support the growth of microbes.
Diseño mecatrónico de una plataforma móvil para asistir tareas en cultivos de café
Authors: Rueda Sánchez Oscar Eduardo , Ruíz Romero Brajan Nicolás , Roa Prada Sebastian , Hernández Barbosa Jeyson
Published: August 2023

Las tareas en los cultivos de café en Colombia se realizan de manera manual y actualmente hay una baja oferta de mano de obra para realizarlas. Por eso, en este artículo se describe el proceso de diseño de una plataforma móvil para ayudar a mitigar el problema anteriormente enunciado. Existen muchas formas para realizar el diseño de la plataforma, por lo tanto, escoger la morfología que más se adecúe es de vital importancia. Para lo anterior, el equipo de diseño utilizó la metodología APTE para seleccionar sin sesgos la morfología que mejor cumplía con los criterios de diseño y con los parámetros encontrados al analizar las necesidades del usuario y las condiciones particulares de operación de la plataforma. Del mismo modo, la topología y la distribución física de los componentes de la plataforma móvil fueron seleccionados con base en un diseño estructural y criterios de análisis obtenidos de un modelo CAD. Los resultados de los métodos aplicados sirvieron como base para construir el prototipo de la plataforma móvil que tiene como objetivo solucionar el problema.
Research trends in meaningful learning in distance education environments: A review of articles published in Q1 to Q3 indexed journal from 2012 to 2022
Authors: Lestari Nita , Winarsih Murni , Kusumawardani Dwi
Published: August 2023

This study aims to investigate the idea that there is a functional and efficient mechanism for meaningful learning. This study is a literature review with various references to data sources. This study's essential focus is on the difficulties and possibilities of meaningful distant learning. An amount of 21 publications had released between 2012 and 2022. Use the SEforRA.com search engine to find information for research. Thematic Analysis to examine the results and show the findings. The research findings shed light on several topics related to meaningful learning, including perceptions, challenges for teachers and students on distance meaningful education, and learning practices. The findings also explain how meaningful learning is in distance learning. The Results show that meaningful learning activities incorporated into distance learning activities enable teachers and students will gain authentic and meaningful experiences that will benefit their education, such as adding teachers' insights for their future teaching practices. The outcomes of this exploratory study have several consequences for anyone involved in remote education, including administrators, teachers, instructional designers, and policymakers, who want to ensure that students have meaningful educational experiences.
Эффект Лейденфроста на струнах
Authors: Артамонов А.В. , Дмитриев А.С. , Макаров П.Г.
Published: August 2023

New manifestations of the Leidenfrost effect (levitation of limited volumes of liquid over an overheated surface) on smooth and morphologically complex thin metal strings are described for the first time. Various dynamic modes of Leidenfrost levitation are presented, including a new one - a combined thermohydrodynamic mechanism of levitation as a sum of the effects of a viscous vapor flow under a drop and a convective flow around a drop with a mixture of vapor + air due to natural convection. Keywords: Leidenfrost effect, thin strings, surface morphology, levitation mechanism, vapor layer.
Mediating and Moderating Effects of Internet Use on Urban-Rural Disparities in Health Among Older Adults: Nationally Representative Cross-Sectional Survey in China
Authors: Liu Jing , Peng Junwei , Chen Minyan , Zhang Tao
Published: August 2023

Background

The urban-rural disparities in health outcomes in China are remarkable. The internet has shown the potential to reduce the likelihood of contracting a disease by increasing disease knowledge. However, little is known about the effects of internet use in alleviating health inequities between urban and rural areas.

Objective

This study aimed to examine the mediation and moderation of health disparities between urban and rural older adults through internet use.

Methods

A total of 8223 respondents were selected from the China Health and Retirement Longitudinal Study 2018 data set. Basic activities of daily living, a brief Community Screening Instrument for Dementia, and the Centre for Epidemiologic Studies Depression Scale were used to measure functional disability, cognitive function, and depressive symptoms, respectively. Logistic regressions testing “internet use×urban-rural status” interactions for moderation and Karlson-Holm-Breen decomposition for mediation were performed.

Results

Internet use moderated the urban-rural disparities in cognitive function (odds ratio 7.327, 95% CI 3.011-17.832) and depressive symptoms (odds ratio 1.070, 95% CI 1.037-1.787), but the moderating effects were significant only for those using the internet daily. Karlson-Holm-Breen results showed the suppression effects of using the internet daily (β=.012, 95% CI .002-.021) on the association between urban-rural status and cognitive function. The urban-rural inequality in depressive symptoms was partially attributed to the disparity in internet use (β=−.027, 95% CI −.043 to −.009).

Conclusions

The urban-rural inequalities in mental health are partially attributable to disparities in the prevalence of internet use between the 2 groups. However, using the internet is more beneficial for the psychological health of rural users, thereby alleviating the urban-rural disparities in health. Providing convenient channels for rural older adults to use the internet, improving the ability of rural users to effectively use the internet, and promoting internet popularity in rural areas are effective approaches to reducing urban-rural health inequalities.
Public Health Risks, Dermatological Manifestations, and Environmental Justice Associated With Vinyl Chloride Exposure: Narrative Review
Authors: Goodman Rachel S , Mittal Lavanya , Parker Eva Rawlings
Published: August 2023

Background

Environmental vinyl chloride (VC) exposure may result in serious acute and chronic dermatological conditions. Because existing literature largely focuses on exposures in occupational settings, a gap persists in our understanding of the medical consequences of large-scale chemical spills.

Objective

This study aims to examine the potential dermatological manifestations of VC exposure in the context of industrial spills and other environmental disasters and to highlight the public health and justice implications of such releases.

Methods

In this narrative review, relevant evidence-based, peer-reviewed scientific sources, gray literature, and media reports were identified via searches of search PubMed and Google using predetermined keyword search terms related to VC, VC spills and releases, train derailment, cutaneous disease, public health, and vulnerable and marginalized populations.

Results

Contact dermatitis and frostbite may arise acutely, highlighting the importance of swift decontamination. Long-term manifestations from chronic VC exposure due to persistence in environmental reservoirs include Raynaud disease, sclerodermatous skin changes, acro-osteolysis, and cutaneous malignancies. The clinical severity of cutaneous manifestations is influenced by individual susceptibility as well as duration, intensity, and route of exposure. Additionally, chemical releases of VC more frequently impact Communities of Color and those of lower socioeconomic status, resulting in greater rates of exposure-related disease.

Conclusions

With environmental release events of hazardous chemicals becoming increasingly common and because the skin has increased contact with environmental toxins relative to other organs, an urgent need exists for a greater understanding of the overall short- and long-term health impacts of large-scale, toxic exposures, underscoring the need for ongoing clinical vigilance. Dermatologists and public health officials should also aim to better understand the ways in which the disproportionate impacts of hazardous chemical exposures on lower-income and minority populations may exacerbate existing health disparities. Herein, we describe the health implications of toxic releases with particular consideration paid to marginalized and vulnerable populations. In addition to legal and regulatory frameworks, we advocate for improved public health measures, to not only mitigate the risk of environmental catastrophes in the future, but also ensure timely and effective responses to them.
Use Patterns of Smartphone Apps and Wearable Devices Supporting Physical Activity and Exercise: Large-Scale Cross-Sectional Survey
Authors: Oba Takeyuki , Takano Keisuke , Katahira Kentaro , Kimura Kenta
Published: August 2023

Background

Physical inactivity is a global health issue, and mobile health (mHealth) apps are expected to play an important role in promoting physical activity. Empirical studies have demonstrated the efficacy and efficiency of app-based interventions, and an increasing number of apps with more functions and richer content have been released. Regardless of the success of mHealth apps, there are important evidence gaps in the literature; that is, it is largely unknown who uses what app functions and which functions are associated with physical activity.

Objective

This study aims to investigate the use patterns of apps and wearables supporting physical activity and exercise in a Japanese-speaking community sample.

Methods

We recruited 20,573 web-based panelists who completed questionnaires concerning demographics, regular physical activity levels, and use of apps and wearables supporting physical activity. Participants who indicated that they were using a physical activity app or wearable were presented with a list of app functions (eg, sensor information, goal setting, journaling, and reward), among which they selected any functions they used.

Results

Approximately one-quarter (n=4465) of the sample was identified as app users and showed similar demographic characteristics to samples documented in the literature; that is, compared with app nonusers, app users were younger (odds ratio [OR] 0.57, 95% CI 0.50-0.65), were more likely to be men (OR 0.83, 95% CI 0.77-0.90), had higher BMI scores (OR 1.02, 95% CI 1.01-1.03), had higher levels of education (university or above; OR 1.528, 95% CI 1.19-1.99), were more likely to have a child (OR 1.16, 95% CI 1.05-1.28) and job (OR 1.28, 95% CI 1.17-1.40), and had a higher household income (OR 1.40, 95% CI 1.21-1.62). Our results revealed unique associations between demographic variables and specific app functions. For example, sensor information, journaling, and GPS were more frequently used by men than women (ORs <0.84). Another important finding is that people used a median of 2 (IQR 1-4) different functions within an app, and the most common pattern was to use sensor information (ie, self-monitoring) and one other function such as goal setting or reminders.

Conclusions

Regardless of the current trend in app development toward multifunctionality, our findings highlight the importance of app simplicity. A set of two functions (more precisely, self-monitoring and one other function) might be the minimum that can be accepted by most users. In addition, the identified individual differences will help developers and stakeholders pave the way for the personalization of app functions.
COVID-19 related network public opinion on the Chinese microblogging platform Weibo: A bibliometric assessment using data from the Web of Science (Preprint)
Authors: Guo ZhenNing , Li JianDi , Zhao ChunYan , Deng YuLong , Dai Jian , Li MingJie , Kong JinLiang , Ning Zong , Chen Gang
Published: August 2023

UNSTRUCTURED

COVID-19 has posed a huge challenge to almost all countries in the world, and its impact on the mentality of society is still ongoing. Exploring the characteristics of network public opinion and conducting effective risk communication are essential aspects of responding to such pandemics. By using bibliometric methods, this study explored the current state of COVID-19-related network public opinion research on Chinese microblogging platform Weibo in the Web of Science Core Collection database. Functions such as collaborative network, word cloud, heat map in R were used to systematically analyze the collaboration situations, highly cited articles, and keywords of the included studies. A total of 281 articles, including 275 research articles and 6 reviews, published in 148 academic journals were collected for the bibliometric investigation. Keyword analysis showed that the relevant topics focused on ‘emotion’, ‘communication’, and ‘infodemiology’. In the late stage of the COVID-19 pandemic, research focus shifted from conceptual descriptions to more diversified and subdivided fields. ‘Content analysis’ and ‘machine learning’ were the most popular methods. For future research, international cooperation should be emphasized, more comprehensive and flexible research methods should also be applied, such as combination of ‘content analysis’ and ‘machine learning’, and ‘MCDM’. In addition, more emphasis should be placed on dialogue and communication skills towards specific populations. In conclusion, this is the first bibliometric assessment to systematically dissect the research status of COVID-19-related network public opinion on Chinese microblogging platform Weibo, which may provide valuable references for subsequent research directions.
Evaluation of Development Policy through Water Environmental Carrying Capacity Analysis in North Kendeng Mountain, Indonesia
Authors: Hadi Sudharto Prawata , Purnaweni Hartuti , Prabawani Bulan , Hamdani Rizkiana Sidqiyatul
Published: August 2023

North Kendeng Mountain has abundant limestone that can potentially be utilized for cement material, cosmetics, paint, and other commercial products. This area also provides water resource storage widely utilized for household use and crop irrigation for local people. This condition has sparked conflict between the government and investors on one side with local people and academicians on the other side. The government and investors, prefer this area for commercial uses while the cons prefer for conservation area. The Strategic Environmental Assessment (SEA) for the North Kendeng ecosystem found that spatial planning and mid-term development planning by the provincial government and related regency governments are oriented toward natural resources utilization and prioritize the area for mining. This paper analyses water environmental carrying capacity implications if the government’s policy and planning are implemented. The type of research is descriptive analysis. The data collection techniques include informal interviews, observation, and literature review. The qualitative data on the development policies are analyzed with content analysis technique including descriptive, interpretative, and explanative. The comparison analysis also conducted to understand the interaction between proposed development activities and the existing environmental condition based on water environmental carrying capacity (WECC) result, and to analyze policy orientation on North Kendeng Mountain Area. After comparing the water demand and availabilityboth with and without government’s policy, this study found that condition of water environmental carrying capacity comparing the demand and availability both with and without policy and planning are deficit for all regencies, except Lamongan regency. This development policy potentially worsens water deficit for all regencies. Therefore, it is suggested that revising the policy and updating the planning are required to achieve sustainable utilization of the North Kendeng Mountain Area.
The effect of vegetation cover on dust concentration: Case study (Constantine, Algeria)
Authors: Benoumeldjadj Maya , Bouarroudj Nedjoua , Bouchareb Abdelouahab
Published: August 2023

Even though urban greenery is crucial in maintaining a healthy and pollution-free environment, metropolitan areas are facing a significant threat from pollution, particularly dust particles. Therefore, this study used the advanced remote sensing techniques to explore the relationship between dust concentration and vegetation cover in Constantine, Algeria. As urban development continues to encroach upon green spaces, pollution, especially dust particles, has emerged as a pressing concern in metropolitan areas. This study used data from USGS and GLOvis for climate analysis, while Landsat images from GEE were employed for accurate mapping. Multiple years of comprehensive datasets were collected, including land cover maps, Aridity Index (AI), precipitation data, and Normalized Difference Vegetation Index (NDVI) maps, which underwent thorough analysis. NDVI and Dust Index (DI) were employed to evaluate the impact of vegetation on dust concentration. The result showed that the presence of vegetation directly affects dust levels, and DI exhibits variations over time in relation to the values of NDVI. This study highlights the critical significance of preserving and enhancing urban greenery to mitigate dust pollution and foster a healthier environment.
Studying JD’s Value Creation-Based Business Model
Authors: Li Zihan
Published: August 2023

People’s spending patterns are changing due to the economy’s quick expansion, and one such change is the advent of e-commerce, which has drawn a lot of investors. This article uses JD as an example to study the fundamental elements of its business model and assess and evaluate it from the standpoint of value creation.
Increasing Employees’ Efficiency through Workforce Management
Authors: Kumari Neeraj
Published: August 2023

The study aims to find out the degree of influence of different factors affecting workforce management and to suggest some measures to increase the workforce management by strengthening the HR factors taken under study. It is a descriptive study. The organization studied is a top Indian real estate company in Delhi. The sample size of the study is 30. The study indicates that workforce management procedure has been effective and systematic to a large extend. Nevertheless, there has been more apprehension/disagreement from some quarters/section of the employees. This is indicative of the fact that there’s always a room for improvement and enhancement. Referral should be taken on priority basis as it is a speedy source of recruitment and gives the sense of loyalty among the employees. Performance appraisal should be undertaken on regular basis and proper feedback on performance should be given by the superior.
Bayesian Formula and Its Application Analysis
Authors: Zhang Yuan , Liu Jia , Shi Saisai
Published: August 2023

Bayesian formula is a very important and widely used formula in probability and statistics courses, which can simplify the probability calculation of certain complex events. This article not only introduces the relevant theories of Bayesian formula, but also explores its practical applications in daily life through examples.
I Am My Own Master: Dewey’s theory of pragmatism on Early Childhood Autonomy-Supporting Development
Authors: Fangyuan Wang
Published: August 2023

Based on Dewey’s pragmatic educational thought, this paper analyses the cultivation content and practical needs of autonomy support for early childhood development. Furthermore, it suggests ways to support children’s autonomy from three key perspectives: the viewpoints of children, interactions with children, and the utilisation of unstructured play materials.