bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlations between ultrafast power Doppler perfusion imaging variables and clinical disease activity in rheumatoid arthritis: potential applications for diagnosing and treating patients in deep clinical remission
Authors: Lai Kuo-Lung , Li Pai-Chi
Published: September 2024

Purpose: This study aimed to evaluate the ability of ultrafast power Doppler (PD) to assess disease activity in rheumatoid arthritis (RA) by examining the correlations between variables from ultrafast PD perfusion imaging and clinical measures of disease activity.Methods: Thirty-three RA patients underwent clinical assessments of disease activity and ultrasound scans of bilateral wrists using both ultrafast and conventional PD systems. A spatial singular value decomposition filter was applied to the ultrafast PD imaging. Singular vectors representing perfusion and fast flows were selected to produce perfusion images. All images were quantitatively analyzed with computer assistance and scored semiquantitatively (0-3) by a physician for synovial vascularity. The Pearson correlation coefficients between image variables and clinical indices were calculated.Results: The correlation coefficients ranged from weakly to moderately positive between ultrafast PD variables and clinical indices (r=0.221-0.374, all P<0.05). The strongest correlations were observed for synovial PD brightness with the 28-joint Disease Activity Score based on C-Reactive Protein (DAS28-CRP) and the Simplified Disease Activity Index (SDAI). In patients within the deep clinical remission (dCR) subgroup, synovial PD brightness showed stronger correlations with DAS28-CRP, the Clinical Disease Activity Index, and SDAI (r=0.578-0.641, all P<0.001). The correlation coefficients between conventional PD variables and clinical indices were similar to those observed with ultrafast PD variables.Conclusion: Ultrafast PD imaging effectively extracts capillary blood signals and generates perfusion images. In the RA population, ultrafast PD variables exhibit weak-to-moderate correlations with clinical indices, with these correlations being notably stronger in dCR patients.
GI-RADS versus O-RADS in the differential diagnosis of adnexal masses: a systematic review and head-to-head meta-analysis
Authors: Perez Marina , Meseguer Ainhoa , Vara Julio , Vilches Jose Carlos , Brunel Ignacio , Lozano Manuel , Orozco Rodrigo , Alcazar Juan Luis
Published: September 2024

Purpose: The aim of this study was to compare the diagnostic performance of the Gynecology Imaging Reporting and Data System (GI-RADS) and Ovarian-Adnexal Reporting and Data System (O-RADS) ultrasound (US) classification systems and assess their capacity to stratify the risk of malignancy in adnexal masses (AMs).Methods: A comprehensive search of MEDLINE (PubMed), Scopus, Web of Science, and Google Scholar was conducted to identify articles published between January 2020 and August 2023. The quality of the studies, the risk of bias, and concerns regarding applicability were assessed using QUADAS-2.Results: The search yielded 132 citations. Five articles, which included a total of 2,448 AMs, were ultimately selected for inclusion. The risk of bias was high in all articles regarding patient selection, low in four studies for the index test, and unclear in three papers for the reference test. For GI-RADS, the pooled sensitivity and specificity were 90.8% (95% confidence interval [CI], 86.0% to 94.0%) and 91.5% (95% CI, 89.0% to 93.0%), respectively. For O-RADS, the pooled sensitivity and specificity were 95.1% (95% CI, 93.0% to 97.0%) and 88.8% (95% CI, 85.0% to 92.0%), respectively. O-RADS demonstrated greater sensitivity for malignancy than GI-RADS (P<0.05). Heterogeneity was moderate for both sensitivity and specificity with respect to GIRADS; for O-RADS, heterogeneity was moderate for sensitivity and high for specificity.Conclusion: Both GI-RADS and O-RADS US demonstrate good diagnostic performance in the preoperative assessment of AMs. However, the O-RADS classification provides superior sensitivity.
El proceso, la prueba y el tiempo del cambio
Authors: Borgia Gianluca
Published: September 2024

En este libro se abordan, en cuatro bloques diferenciados, los cambios o adaptaciones que debe afrontar el Derecho Procesal y el Derecho Probatorio. Empezando por la irrenunciable protección de los derechos fundamentales. Encontrar el punto de equilibrio entre la eficacia, acortando límites temporales, en la investigación criminal y el respeto de las garantías inherentes al Estado de Derecho es la clave. Se ha superado una “anemia legislativa” en materia de diligencias de investigación tecnológicas, pero, al mismo tiempo, es imprescindible que las mismas se enmarquen bajo la cobertura de determinados derechos fundamentales. Han surgido nuevas formas de criminalidad con manifestaciones o réplicas más allá de un espacio geográfico determinado. La mejora de los instrumentos de cooperación judicial ciertamente puede soslayar determinadas controversias que con las herramientas tradicionales era imposible. Pero, se insiste, sin renunciar a los principios y garantías procesales. En materia civil (y constitucional), la regulación del incidente de nulidad de actuaciones, como paso previo al recurso de amparo, nunca ha sido pacífica. Todo lo contrario, ha permanecido en constante evolución y transformación con el objeto de velar por el respeto de los derechos y libertades fundamentales. Y si hablamos de cambios, el desarrollo tecnológico tenía que aparecer y se convierte en protagonista de la segunda parte de esta obra. La prueba electrónica, medio probatorio autónomo -o no tanto- respecto de la prueba documental, se ha convertido en la prueba “reina”. O la Inteligencia Artificial, y los sistemas de justicia predictiva, concebidos ahora como herramienta ex ante para facilitar (o, incluso, sustituir) la actuación de los operadores jurídicos. Todas estas cuestiones se analizan y desde distintos órdenes jurisdiccionales (penal, civil y laboral). Buscar una alternativa al proceso judicial, en aras de una mayor simplificación y aceleración del mismo, centra el tercer bloque. Los medios alternativos de solución de controversias (MASC-ADR) han focalizado el debate normativo de los últimos meses, igual que el tratamiento de las cláusulas abusivas lo ha hecho con la jurisprudencia, tanto a nivel europeo como nacional. El control de las cláusulas abusivas, motivado por cambios económicos, y la protección de la víctima del delito y víctima vulnerable, que ha experimentado una transición por razones de bienestar y evitar su victimización secundaria, son tratados en el cuarto y último apartado de este libro. Para el proceso y la prueba es el tiempo del cambio y esperemos que, a diferencia de la lírica, corran buenos tiempos.
Analisis Spasial Faktor-Faktor yang Mempengaruhi Kejadian Tuberkulosis di Malang Raya Tahun 2020-2021
Authors: Olivionita Vita , Wardani Hartati Eko , Alma Lucky Radita , Gayatri Rara Warih
Published: September 2024

Background: Indonesia is the second country with the highest TB burden in the world. The government continues to strive for TB prevention and control to reduce TB rates. One of the efforts that can help in the TB program is by utilizing a Geographic Information System (GIS)Methods: The study is an ecological study; GIS as an approach. Data was obtained from the Health Service in Malang Raya and the Central Bureau of Statistics’ websiteResult: Study results are the pattern of distribution of TB incidence that tends to be high occurs in areas that have low coverage of healthy houses, low coverage of houses with healthy lifestyle, high population density, low air temperature, high air humidity, and high rainfall.Conclusion : The pattern of distribution of TB incidence that tends to be high occurs in areas that have low coverage of healthy houses, low coverage of houses with PHBS, high population density, high air temperature, high air humidity, and high rainfall.
Factors Water Characteristic and Exclusive Breastfeeding as Predicting Diarrhea Under 5 Years
Authors: Susanto Nugroho , Hidayani Wuri Ratna
Published: September 2024

Background: The incidence of death diarrheal disease for children under 5 years are 5 million. The prevalence of diarrhea up to 24.8%.  The exclusive breastfeeding for infants up to 6 months will provide immunity to against various diseases such as diarrhea. The proportion of Infants not exclusive breastfeeding up to 65.8%. Factors such as washing hands, consumption of drinking water are factors caused diarrhea in children. The study aims to known at the prediction of the risk of diarrhea and the dominant factors related the incidence of diarrhea in Kebumen District.Methods: The study design used case control. The population is mothers who have toddlers 1-4 years in the working area of Berbah Health Center Services was estimated 3,407 toddlers. The sample of case is a toddler who suffers from diarrhea and the control is a toddler who does not suffer from diarrhea in the surrounding environment. The sample was estimated of 50 cases of diarrhea and 50 control without diarrhea who qualified inclusion and exclusion criteria. The instruments were used questionnaires and medical records of diarrhea. Data were analysis with chi square test and logistic regression with 95% confidence interval.Result: Based on bivariate analysis shown that the exclusive breastfeeding was significant risk of diarrhea incidence OR = 3.22 (1.41-7.35). Based on Handwashing that the handwashing variable has no significant risk of diarrhea incidence OR = 1.792 (0.80-4.01). Based on multivariate analysis that exclusive breastfeeding significant caused diarrhea for children OR = 2.76 (95%CI: 1.18-6.47) whereas hand washing did not significantly cause diarrhea in children OR = 1.15 (95% CI: 0.66-3.64) and drinking water did not significantly affect diarrhea in children OR 2.19 (95% CI: 0.91-5.27).Conclusion: The study concluded that the dominant risk factor significantly for diarrhea in toddlers is exclusive breastfeeding.
Effect of endothelin‐1 on the blood pressure response to acute hypoxia and hyperoxia in healthy young men
Authors: Gonsalves Anna M. , Baker Sarah E. , Jacob Dain W. , Harper Jennifer L. , Manrique‐Acevedo Camila M. , Limberg Jacqueline K.
Published: September 2024

Endothelin‐1 (ET‐1) and its receptors are linked to increases in sensitivity of the chemoreceptors to hypoxic stress and the development of hypertension in preclinical models. We hypothesized ET receptor antagonism would lower resting blood pressure (BP) as well as the acute BP response to chemoreflex stress. Twenty‐four men (31 ± 5 years, 26 ± 3 kg/m2) completed two study visits (control, bosentan). On each visit, BP was assessed under three conditions: (1) normoxia (FiO2 0.21), (2) chemoreflex excitation via hypoxia (FiO2 0.05–0.21), (3) chemoreflex inhibition via hyperoxia (FiO2 1.00). Bosentan increased plasma ET‐1 (0.94 ± 0.90 to 1.27 ± 0.62 pg/mL, p = 0.004), supporting receptor blockade. Resting diastolic (73 ± 5 to 69 ± 7 mmHg, p = 0.007) and mean (93 ± 7 to 88 ± 7 mmHg, p = 0.005) BP were reduced following bosentan compared to control with no change in systolic BP (p = 0.507). The mean BP response to both acute hypoxia (−0.48 ± 0.38 to −0.25 ± 0.31 mmHg/%, p = 0.004) and hyperoxia (area under the curve −93 ± 108 to −27 ± 66 AU, p = 0.018) were attenuated following bosentan. Acute ET receptor inhibition attenuates the rise in BP during chemoreflex excitation as well as the fall in BP during chemoreflex inhibition in healthy young men. These data support a role for ET‐1 in control of resting BP, possibly through a chemoreceptor‐mediated mechanism.
The effect of posture on the age dependence of neurovascular coupling
Authors: Ball James D. , Davies Aaron , Gurung Dewakar , Mankoo Alex , Panerai Ronney , Minhas Jatinder S. , Robinson Thompson , Beishon Lucy
Published: September 2024

Previous studies report contradicting age‐related neurovascular coupling (NVC). Few studies assess postural effects, but less investigate relationships between age and NVC within different postures. Therefore, this study investigated the effect of age on NVC in different postures with varying cognitive stimuli. Beat‐to‐beat blood pressure, heart rate and end‐tidal carbon dioxide were assessed alongside middle and posterior cerebral artery velocities (MCAv and PCAv, respectively) using transcranial Doppler ultrasonography in 78 participants (31 young‐, 23 middle‐ and 24 older‐aged) with visuospatial (VST) and attention tasks (AT) in various postures at two timepoints (T2 and T3). Between‐group significance testing utilized one‐way analysis‐of‐variance (ANOVA) (Tukey post‐hoc). Mixed three‐way/one‐way ANOVAs explored task, posture, and age interactions. Significant effects of posture on NVC were driven by a 3.8% increase from seated to supine. For AT, mean supine %MCAv increase was greatest in younger (5.44%) versus middle (0.12%) and older‐age (0.09%) at T3 (p = 0.005). For VST, mean supine %PCAv increase was greatest at T2 and T3 in middle (10.99%/10.12%) and older‐age (17.36%/17.26%) versus younger (9.44%/8.89%) (p = 0.004/p = 0.002). We identified significant age‐related NVC effects with VST‐induced hyperactivation. This may reflect age‐related compensatory processes in supine. Further work is required, using complex stimuli while standing/walking, examining NVC, aging and falls.
Forecasting gasification sustainability through enhanced K-nearest neighbour models for hydrogen and nitrogen amount
Authors: Du Feng
Published: September 2024

This study pioneers a method for forecasting hydrogen and nitrogen quantities in gasification processes, which is crucial for transforming carbon-based materials into valuable gases with minimal environmental impact. It addresses the pressing need for precise and economical solutions in gasification by streamlining estimation procedures across various operational conditions. Anchored in historical data, the K-nearest neighbour’s (KNN) model forms the core of this method, adeptly capturing intricate relationships between input variables and gas production results. What sets this research apart is the integration of advanced optimization techniques, Beluga whale optimization (BWO), and Northern Goshawk Optimization (NGO), further refining the accuracy of the KNN model’s predictions. This work signifies a substantial stride in optimizing gasification processes, offering a pathway towards more efficient and sustainable conversion of carbon-based materials, showcasing the potential of data-driven sustainability in this domain, and ultimately diminishing the environmental impact of these operations. Results highlight the outstanding predictive performance of the KNNG model, achieving an impressive R
2 value of 0.995 and 0.994 during training. Notably, both the KNNG and KNBW models outperformed the basic KNN model in forecasting gasification outputs, underscoring the reliability and effectiveness of these optimized models in predicting these processes.
Flows of geometric structures
Authors: Fadel Daniel , Loubeau Eric , Moreno Andrés J. , Sá Earp Henrique N.
Published: September 2024

We develop an abstract theory of flows of geometric 𝐻-structures, i.e., flows of tensor fields defining 𝐻-reductions of the frame bundle, for a closed and connected subgroup

H
⊂

SO
⁢

(
n
)

H\subset\mathrm{SO}(n)

, on any connected and oriented 𝑛-manifold with sufficient topology to admit such structures.
The first part of the article sets up a unifying theoretical framework for deformations of 𝐻-structures, by way of the natural infinitesimal action of

GL
⁢

(
n
,
R
)

\mathrm{GL}(n,\mathbb{R})

on tensors combined with various bundle decompositions induced by 𝐻-structures.
We compute evolution equations for the intrinsic torsion under general flows of 𝐻-structures and, as applications, we obtain general Bianchi-type identities for 𝐻-structures, and, for closed manifolds, a general first variation formula for the

L
2

L^{2}

-Dirichlet energy functional ℰ on the space of 𝐻-structures.
We then specialise the theory to the negative gradient flow of ℰ over isometric 𝐻-structures, i.e., their harmonic flow.
The core result is an almost-monotonocity formula along the flow for a scale-invariant localised energy, similar to the classical formulas by Chen–Struwe [M. Struwe, On the evolution of harmonic maps in higher dimensions, J. Differential Geom.
28 (1988), 3, 485–502; Y. M. Chen and M. Struwe, Existence and partial regularity results for the heat flow for harmonic maps, Math. Z.
201 (1989), 1, 83–103] for the harmonic map heat flow.
This yields an 𝜀-regularity theorem and an energy gap result for harmonic structures, as well as long-time existence for the flow under small initial energy, relative to the

L
∞

L^{\infty}

-norm of initial torsion, in the spirit of Chen–Ding [Y. M. Chen and W. Y. Ding, Blow-up and global existence for heat flows of harmonic maps, Invent. Math.
99 (1990), 3, 567–578].
Moreover, below a certain energy level, the absence of a torsion-free isometric 𝐻-structure in the initial homotopy class imposes the formation of finite-time singularities.
These seemingly contrasting statements are illustrated by examples on flat 𝑛-tori, so long as the set

[

S
n

,

SO
⁢

(
n
)

/
H

]

[\mathbb{S}^{n},\mathrm{SO}(n)/H]

of homotopy classes of maps

S
n

→

SO
⁢

(
n
)

/
H

\mathbb{S}^{n}\to\mathrm{SO}(n)/H

contains more than one element and the universal cover of

SO
⁢

(
n
)

/
H

\mathrm{SO}(n)/H

is a sphere, e.g. when

n
=
7

n=7

and

H
=

G
2

H=\mathrm{G}_{2}

, or

n
=
8

n=8

and

H
=

Spin
⁢

(
7
)

H=\mathrm{Spin}(7)

.
Dynamical mixed boundary-transmission problems of the generalized thermo-electro-magneto-elasticity theory for composed structures
Authors: Buchukuri Tengiz , Chkadua Otar , Natroshvili David
Published: September 2024

In the present paper we investigate three-dimensional dynamical mixed boundary-transmission problems for
composed body consisting of two adjacent anisotropic elastic components having a common interface surface.
The two contacting elastic components are subject to different mathematical models: Green–Lindsay’s model of
generalized thermo-electro-magneto-elasticity in one
component and Green–Lindsay’s model of generalized thermo-elasticity in the other one.
We assume that the composed elastic structure under consideration contains an
interfacial crack.
We prove the uniqueness and existence theorems in appropriate function spaces.
Review: research progress on the extraction and utilization of polysaccharide components in grey dates
Authors: Liu Bin , Gao Kun , Qiu Chengcheng , Wu Bengang , Guo Yiting , Ma Wenpeng , Song Chenyu , Nan Shenao , Dai Junjun , Shen Yan , Ma Haile
Published: September 2024

China is the largest producer of jujubes in the world, with the Xinjiang region accounting for about 50 % of the total production. However, local jujube processing still relies on traditional methods, leading to reduced industrial efficiency. Research shows that jujube polysaccharides possess various biological properties, such as antioxidant, anti-tumor, and anti-inflammatory activities. Enhancing the extraction of jujube polysaccharides to boost their food, medicinal, and economic value has become an important development direction of the jujube industry. This paper reviews the current research on the active functions of grey jujube polysaccharides, extraction technologies, and recent advancements in their production and application. It systematically introduces both traditional and emerging extraction technologies and summarizes the current state of production and application of grey jujube polysaccharides. The aim is to provide references for other researchers interested in jujube polysaccharides and to extend the value chain of the grey jujube industry.
L’exception saxonne: le curieux cas d’Ariohan dans le Cycle de
Guiron le Courtois
Authors: Conti Inès
Published: September 2024

Réputé pour sa tonalité tant belliqueuse qu’épique, le Roman de Meliadus, premier volet du Cycle de Guiron le Courtois, se solde sur une invasion saxonne et le conflit armé qui en découle. Héros éponyme du texte, le roi Méliadus de Léonois, père de Tristan, fait partie des forces arthuriennes au combat et luttera dans un duel final contre Ariohan, prince des Saxons à leur tête. Ariohan se révèle un personnage non seulement individualisé, émergeant de la masse saxonne que connaissent habituellement les romans arthuriens en prose, mais également courtois, valeureux, digne d’un statut arthurien que d’autres personnages extérieurs au royaume de Logres ne connaissent que rarement. Cet article étudie l’élaboration de ce personnage au fil du Meliadus ainsi que son intertextualité arthurienne.
The Linguistic Provenance of the Hebrew King Arthur (1279) Reassessed
Authors: Jacobowitz-Efron Leon
Published: September 2024

Based on its inclusion of non-Hebrew Italian loanwords and the sole surviving manuscript copy being Italian, the current consensus among scholars is that an Italian Jew authored Melekh Artus (1279), the only extant medieval Hebrew translation of Arthurian material. The following study destabilizes this consensus opinion demonstrating why these loanwords are a precarious tool when ascertaining this text’s linguistic provenance. Not only are most of the said loanwords not necessarily Italian, but, using Italian copies of the French biblical commentator Rashi, this study establishes that Jewish Italian scribes sometimes Italianized Old French loanwords they encountered in their Hebrew sources. Thus, the few loanwords that are Italianisms do not prove Italian authorship but merely that the sole surviving copy was produced by an Italian-Jewish scribe adhering to the scribal conventions of his times.
L’
annominatio
en question dans quelques textes arthuriens en vers (xiie
-xiiie
siècles): généralités et applications à l’étude des rimes
Authors: James-Raoul Danièle
Published: September 2024

L’annominatio est une figure de rhétorique qui met en jeu la forme sonore, voire graphique, d’un mot en lien avec un ou d’autres mots selon de multiples modalités: elle est fondamentalement une figure de diction mais, dans la mesure où la répétition en est un élément constitutif essentiel, elle tient aussi d’une figure de construction. À l’époque médiévale, l’annominatio conditionne l’esthétique littéraire en général, l’écriture des vers en particulier, leur récitation ou leur lecture; elle n’est évidemment pas spécifique de la littérature arthurienne, mais la coloration et le dynamisme qu’elle apporte à ces textes permet d’entrer dans le style de leurs auteurs, de particulariser leur plume, voire, sur certains points, de l’identifier. Elle fait entendre le caractère très sonore de la langue française de cette époque. Comme toute figure de style, elle a un rôle argumentatif (elle insiste, souligne, établit des liens implicites et symboliques entre ce qui, a priori, semble ne pas en avoir, elle aide à la mémorisation) et un rôle ornemental (elle est plaisante, elle induit la variation ou la surprise, conduit le rythme, elle creuse des sillons sonores, graphiques et sémantiques dans la platitude du texte). Dans la succession de mètres courts comme les octosyllabes à rimes suivies, elle possède une importance particulière, parce qu’elle investit par prédilection la rime, en exemplifie les possibles réalisations et c’est sur ce sujet que je concentrerai mon attention dans la seconde partie de cette étude. S’intéresser à l’annominatio aux xii
e et xiii
e siècles dans quelques textes jalonnant la littérature arthurienne, c’est attirer l’attention sur l’histoire littéraire, l’esthétique et les considérations grammairiennes sur le langage telles qu’on peut les trouver dans les arts poétiques, autant que sur l’art de la versification dans nos romans, trop souvent laissé pour compte.
A Schema for Artorius: History, John Heath-Stubbs, and the Last Modernist Epic
Authors: Wise Dennis Wilson
Published: September 2024

Although John Heath-Stubbs’s long modernist epic Artorius is largely unknown, this ambitious text combines a cyclical vision of history with a linear one on its way to understanding Great Britain’s loss of imperial status. If this point has generally been missed, the complexity of Heath-Stubbs’s multiple symbolic superstructures partly accounts for the text’s unfortunate reception. Accordingly, I present an explanatory schema for Artorius in line with what other modernist texts – most famously Joyce’s Ulysses – have benefitted from. Besides unpacking the symbolic superstructures used by Heath-Stubbs, I also address how the poet, who lived in Egypt during the 1956 Suez crisis, uses them to answer a British nation that can no longer identify as a global power.
The Japanese Branch of The International Arthurian Society. Part One. General Issues and English
Authors: Fuwa Yuri
Published: September 2024

Presentation of the Japanese Branch of the International Arthurian Society, including a discussion of the contribution of its members to international Arthurian scholarship, especially on Malory studies, in English Arthuriana.
Selpercatinib prior to radioactive iodine for pediatric papillary thyroid carcinoma
Authors: Chiu Harvey K. , Nowicki Theodore S. , Livhits Masha J. , Wu James X. , Federman Noah
Published: September 2024

Objectives

We introduced selpercatinib prior to radioactive iodine therapy prior to radioactive iodine therapy (RAI) for pediatric papillary thyroid cancer (PTC) to enhance the tumorical effects of RAI.

Case presentation

PTC has an excellent prognosis but is commonly associated with local and distant metastases. Successful complete response to the current standard of care, thyroidectomy with lymph node resection and RAI, is achieved in only a small minority of cases with metastases. The direct effect of tyrosine kinase inhibitors (TKIs) on tumor regression has been confirmed in several randomized controlled studies, while the increased RAI uptake has been reported in small case series, but typically TKIs are currently reserved third-line. Selpercatinib is a TKI that specifically has a durable effect in RET-fusion positive malignancies. We describe a 10-year-old Hispanic girl with metastatic PTC treated with total thyroidectomy and extensive lymph node resection. Evaluation for relevant genetic drivers of the malignancy revealed a strong overexpression of the RET tyrosine kinase domain indicative of a RET gene fusion. Selpercatinib 120 mg twice daily given orally was initiated prior to the initial dose of RAI to achieve further tumor regression by a direct cytostatic effect and then secondarily enhancement of RAI uptake. Minimal side effects occurred, specifically intermittent mild skin rashes that resolved. Resolution of distal lung metastases was noted on CT imaging. RAI was then administered 9 months afterward, with ultimately achievement of a low thyroglobulin level 1.0 ng/mL 11 months after RAI.

Conclusions

In conclusion, selpercatinib given prior to the initial dose of adjunctive RAI for RET-fusion positive PTC is a well-tolerated intervention that further reduces tumor burden and potentially enhances the tumorcidal effects of RAI.
Influence of post heat treatment on tribological and microstructural properties of plasma wire arc additive manufactured maraging steels
Authors: Kaya Esad , Ulutan Mustafa , Çakır Ersin , Buytoz Soner
Published: September 2024

Metallic alloys are increasingly being produced using wired arc additive manufacturing (WAAM). In this study, 18Ni300 defect-free maraging steels were produced using the WAAM technique. A traditional solution treatment, direct aging, and cryogenic heat treatment processes were applied to the WAAM produced maraging steels. The influence of conventional and novel cryogenic heat treatments on microstructural, mechanical, and tribological properties were examined. The microstructure of the as-built materials obtained by WAAM thermal cycling has mainly been homogenized through the solution, direct-aging, and cryogenic heat treatments. As a result, homogeneously distributed precipitate phases were obtained and the hardness increased by 30 % with a combination different post heat treatments. The cryogenic heat treatment improved the martensitic transformation and facilitated the formation of various Fe–Ni–Mo–Ti-containing intermetallic precipitates. Similarly, because of the different heat treatments, the wear resistance improved by a factor of 2–5.5 relative to the as-built material. Adding the cryogenic heat treatment to the traditional heat treatment procedure improves wear resistance by a factor of 1.2–2.9.
The crystal structure of 2-ethyl-1,1-dimethyl-1H-benzo[e]indole, C16H17N
Authors: Liu Pengjue , Li Linlu , Yang Fei , Wang Zongwei , Guo Libing , Huo Cuimeng
Published: September 2024

C16H17N, orthorhombic, Pbca (no. 61), a = 10.3706(10) Å, b = 8.3879(7) Å, c = 29.555(3) Å, V = 2,570.9(4) Å3, Z = 8, R

gt
(F) = 0.0579, wR

ref
(F
2) = 0.1327, T = 293(2) K.
Crystal structure of a (E)-4-bromo-N-(4-(diethylamino)-2-hydroxybenzylidene) benzenaminium acetate ─ 4-bromoaniline (1/1)
Authors: Oladipo Segun D. , Zamisa Sizwe J. , Luckay Robert C.
Published: September 2024

C25H29Br2N3O3, orthorhombic, Pbca (61), a = 20.109(5) Å, b = 10.754(5) Å, c = 24.321(5) Å, V = 5,259(3) Å3, Z = 8, R
gt(F) = 0.0464, wR
ref(F
2) = 0.1156, T = 295 K.
The crystal structure of bis(3-oxo-1,3-diphenylprop-1-en-1-olato-κ
2
O:O′)-bis(1,4-dioxane-κ
1
O)nickel(II), C38H38O8Ni
Authors: Wei Fanzhi
Published: September 2024

C38H38O8Ni, orthorhombic, Cmc21 (no. 36), a = 19.0266(4) Å, b = 8.2409(2) Å, c = 21.4315(5) Å, V = 3,360.38(13) Å3, Z = 4, Rgt
(F) = 0.0406, wRref
(F
2) = 0.1058, T = 293 K.
Exploring the mechanism of genistein in treating hepatocellular carcinoma through network pharmacology and molecular docking
Authors: Wang Siliang , Chen Wenlian , Dong Changsheng , Wu Jia , Zheng Miaomiao , Ma Yushui , Xue Yuwen
Published: September 2024

Objectives

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, with treatment options limited and outcomes often poor, especially in advanced stages. This study explores the therapeutic potential of genistein, a soybean-derived isoflavone, on HCC using network pharmacology to uncover its multi-targeted anti-cancer mechanisms.

Methods

Potential targets of genistein were predicted using databases such as Super-PRED, PharmMapper, and SwissTargetPrediction. Abnormally expressed genes in HCC tissues were analyzed from TCGA and GEO datasets, with genes linked to the prognosis of HCC patients selected as potential therapeutic targets. GO and KEGG pathway enrichment analyses were conducted for both genistein’s targets and the HCC-related gene set. Key targets were identified through network analysis using Cytoscape software. Molecular docking was performed with Autodock to assess the binding affinity between genistein and these key targets. The therapeutic effects of genistein on HCC were validated through animal experiments and cell line studies.

Results

This study identified 343 potential targets for genistein in treating hepatocellular carcinoma (HCC). Analyses revealed enrichment in cell cycle regulation pathways through GO and KEGG assessments. Transcriptomic data from HCC datasets unveiled 184 potential therapeutic targets, emphasizing cell cycle regulation. Notably, 12 proteins were identified as targets of both genistein and HCC treatment. Molecular docking studies demonstrated genistein’s strong binding affinity with CDC25C and MELK. In vitro and in vivo validations affirmed genistein’s role in inhibiting HCC proliferation by inducing G2/M phase arrest. This study elucidates genistein’s multi-target mechanism in suppressing HCC cell proliferation, supporting its potential clinical application in HCC treatment.

Conclusions

This study demonstrates that genistein effectively suppresses the malignant growth of HCC by interfering with the transition from the G2 to M phase, revealing a multifaceted mechanism of action.
Radiochemical separation of 161 Tb from neutron irradiated Gd target by liquid-liquid extraction technique
Authors: Shahr El-Din Ahmed M. , Gizawy Mohamed A. , Borai Emad H.
Published: September 2024

No-carrier-added (NCA) 161 Tb, which has advisable nuclear properties to be applied for cancer radiotherapy was produced at the Egyptian Second Research Reactor (ETRR-2) by neutron irradiation of natural gadolinium target via indirect nuclear reaction. The radiochemical separation of 161 Tb from irradiated gadolinium target was investigated based on solvent extraction technique using Cyanex 302. Several separation parameters were checked and optimized. According to the obtained results, the separation process of the investigated radioisotopes proceeds in two steps. The first step is an extraction of all of them into the organic phase in which the extraction % (98 %) was optimized at pH 4, 0.15 M of Cyanex 302 and 2.5 h extraction time. Moreover, the slope analysis method confirmed the participation of 2 mol of the organic extractant for the separation of 161 Tb from irradiated gadolinium. The second step is the separation of the 161 Tb isotope that was purified by the stripping of 159Gd with a citrate solution at pH 9, which is considered as a highly efficient and promising method for separation and purification of the two radioisotopes.
Aproximación geomecánica usando velocidades de onda y su relación con el parámetro “b”
Authors: Espinoza Peter
Published: September 2024

In this research, an exhaustive and rigorous analysis about microseismicity and its importance for the analysis of geological structures will be presented, with special attention on the application of the GSI table and its relationship with safety. Microseismicity is the technique of detection and analysis of small seismic events that occur during the advance and mining exploitation, and its study is fundamental to guarantee a safe and efficient operation. The presence of these seismic events indicates the existence of stresses and deformations in the geological structures, which can have a significant impact on the safety of the operation. Therefore, microseismicity monitoring is an essential tool for geomechanical risk management. In this thesis the relationship between microseismicity and geological structures will be explored, using the GSI table as an important tool for the interpretation of microseismic data. The GSI table is a tool developed by the International Society for Rock Mechanics to assess the geomechanical stability of rock structures. In this work, the microseismic data will be analyzed and correlated with the GSI table, which will allow a better understanding of the geomechanical characteristics of the mine and a more accurate evaluation of geomechanical risk.
The university as an ally for active aging and quality of life
Authors: Areosa Silvia Virginia Coutinho , Freitas Cristiane Davina Redin , Kipper Liane Mahlmann , Lampert Melissa Agostini , Klafke Rafaele Luiza , Rosa Diorginis Luis Fontoura da
Published: September 2024

This article discusses the health status of older persons participating in an extension course lasting two years at the University of Santa Cruz do Sul/RS, Brazil, from a descriptive quantitative and qualitative study conducted in 2014 and 2015, with 47 persons over 60. Instruments were used to assess the elders' cognitive functions and overall health. The study presents the perspective of successful aging focusing on the following aspects: low probability of disease, good functional capacity (physical and cognitive), and active participation in the community. The studied sample has characteristics that corroborate the general health status and quality of life conditions, such as the many years of study, the continuous search for knowledge-related activities, the involvement in different physical and leisure activities, and socializing with family and friends. The research indicates that the insertion in university programs contributes to the prevention of cognitive decline and the general state of health, contributing to self-esteem and maintenance of mental health, which reflects in aging with quality of life.
Glibenclamide alters the brain protein profile and morphometry of hippocampal regions in mice fed with a high-refined carbohydrate diet
Authors: dos Santos Paula Viana Sene , Sant’Ana de Faria Sttefany Nayara , Miranda e Castor Renata Gomes , Roriz Tiago Cereza , Santos Ferreira Gabriela Lícia , Assis Cau Stêfany Bruno de , Karen Calábria Luciana
Published: September 2024

A high-refined carbohydrate diet (HC diet) has shown impacts not only on metabolic disorders, but also on cognitive and behavioral functions. However, its effects at the protein and morphological level in the brain are not known. In order to investigate the differential expression of proteins in the brain of Balb/c mice fed with a HC diet and treated or not with glibenclamide, biochemical and histological assays were performed. The brains of animals fed for eight weeks with a standard rodent diet or HC diet, and treated or not with glibenclamide for four weeks were homogenized and the supernatant was subjected to 12.5% ​​SDS-PAGE. The brains were also blocked and 3 μm sections were stained with Hematoxylin-Eosin and analyzed using light microscopy. The electrophoretic profile of samples from untreated animals revealed protein expression without significant differences, while the group treated with glibenclamide revealed protein bands with differential expression (44.8, 42.2 and 39.8 KDa). The proteins were predicted using a bioinformatic tool and it is suggested that, for the most part, they are related to the energy metabolism of the brain. Histological analysis of the hippocampus demonstrated similarities between animals fed with a standard diet and HC diet, but with differences in the number of neurons in the CA2 and CA3 regions, and a tendency to cell death in the dentate gyrus of animals group HC diet. These results revealed one of the regions of the brain affected by excess carbohydrates, as well as candidate proteins for proteomic analysis to further investigate the effects of dietary sugars on molecular mechanisms and neurogenesis in the hippocampus.
Simultaneous quantification of the main components of Thymus vulgaris essential oil in edible coating formed from nanocapsules using HS-SPME-GC-FID
Authors: González-Moreno Barbara Johana , Galindo-Rodríguez Sergio Arturo , Pérez-López Luis Alejandro , Portillo-Castillo Omar J. , Álvarez-Román Rocío
Published: September 2024

The use of edible coatings (ECs) containing essential oils (EOs), such as that derived from the Thymus vulgaris plant (EO-Tv), offers a natural option for preserving and increasing the shelf life of fruit and vegetable products. However, considering their physicochemical properties, the incorporation of EOs into nanocapsules (NCs) represents an alternative to reduce their volatility and oxidation. In this way, quantitative determination of the EOs incorporated into NCs is necessary for simultaneous monitoring of their main components during the nanoencapsulation process, as well as for the future precise and accurate dosage of EO components in fruit and vegetable products. In this study, ECs were formed from NCs loaded with EO-Tv and sodium alginate (AL). The EO-Tv was characterized through GC-MS and GC-FID analysis, and it was found that the major component of EO-Tv was thymol, with an abundance of 30.91%. Subsequently, an analytical method based on HS-SPME-GC-FID was developed and validated for quantification of the EO-Tv encapsulated in NCs and incorporated into the EC. The method was found to be precise and accurate for quantification of the main components of EO-Tv in the formed EC. Once the analytical method was validated, it was established that the encapsulation efficiency was greater than 50% in the case of NC-EO-Tv purified via evaporation at reduced pressure. On the other hand, 35.78 μg cm−2 of thymol was quantified in the EC formed from the NCs and AL. The present work presents an analytical tool for simultaneous quantification of the main components of EO-Tv in NCs, as well as in the ECs formed with NCs, promoting its potential application in fruit and vegetable products.
Effects of aerobic exercise at different intensities on articular cartilage in mice
Authors: He Chunxiao , Tsubaki Toshiya , Inoue Shota , Hatakeyama Junpei , Jiang Hanlin , Moriyama Hideki
Published: September 2024

Background

Maintaining intrinsic articular cartilage homeostasis is essential for the health of cartilage. However, the impact of aerobic exercise of varying intensities on the articular cartilage homeostasis has never been studied. This study aims to elucidate the influence of different aerobic exercise intensities on the anabolic and catabolic processes within articular cartilage.

Methods

Forty-eight male C57BL/6J mice, aged 7 weeks, were divided into 4 aerobic exercise groups and 1 control group. The aerobic exercise groups were subjected to both acute and chronic exercise protocols with varying intensities of 8, 12, 16, 20, and 24 m min−1. Total RNA from the knee joint cartilage was extracted in both phases to quantify mRNA of anabolic (Sox9, Col2a1, and Acan) and catabolic (MMP-13 and ADAMTS5) markers. In the chronic exercise, articular cartilage thickness and chondrocyte density were histologically assessed. Additionally, immunohistochemical staining quantified relevant molecules involved in cartilage metabolism.

Results

In the acute exercise, the 8 m min−1 group exhibited reduced ADAMTS5 expression compared to the control, 16 m min−1, and 24 m min−1 groups. Chronic exercise showed enhanced articular cartilage thickness in both the 8 and 12 m min−1 groups relative to the control group. Moreover, the 8 m min−1 group demonstrated elevated aggrecan levels in comparison to both the control and 24 m min−1 groups. Additionally, the 24 m min−1 group exhibited significantly higher ADAMTS5 levels than the control group.

Conclusion

Our findings suggest that consistent low-intensity aerobic exercise suppresses catabolic molecule expression in articular cartilage, thereby fostering anabolic activity. Conversely, continuous high-intensity aerobic exercise can potentially disrupt cartilage homeostasis by enhancing catabolic processes. This dichotomy underscores the need for balanced exercise regimens to maintain cartilage health.
Buzhong Yiqi decoction attenuates acquired myasthenia by regulating the JAK2/STAT3/AKT signaling pathway, inhibiting inflammation, and improving mitochondrial function
Authors: Zeng Yuanfeng , Zeng Haihua , Liu Xinghua , Fan Tingting
Published: September 2024

Acquired myasthenia (AM), a debilitating autoimmune disease, is typically characterized by skeletal muscle fatigue and weakness. Despite advances in myasthenia gravis treatment, current approaches remain unsatisfactory and many result in unexpected side effects. Traditional Chinese medicine has shown great potential in the treatment of myasthenia gravis, including relieving myasthenic symptoms, improving patients' quality of life, and reducing Western medicine side effects. This study investigates the protective effects and mechanism of BZYQD in mice with acquired myasthenia. BZYQD alleviates the reduced grip strength and increased expression of MAFbx and MuRF-1 in mice with acquired myasthenia. It also reduces levels of pro-inflammatory factors IL-1β, IL-6, and TNF-α in the mouse serum. In addition, BZYQD reduces ROS accumulation and the mitochondrial ROS production rate, while increasing ATP levels and mitochondrial membrane potential in mice with acquired myasthenia. Moreover, BZYQD decreases the expression of p-JAK2, p-STAT3, and p-AKT in the skeletal muscle of mice with acquired myasthenia. In summary, BZYQD reduces inflammation, enhances mitochondrial function, and regulates the JAK2/STAT3/AKT signaling pathway to treat acquired myasthenia.
RE: Cold-induced urticaria and development of anaphylaxis
Authors: Özdemir Öner
Published: September 2024

N/A
HISTÓRIAS EM QUADRINHOS COMO RECURSO DIDÁTICO-PEDAGÓGICO PARA AUXÍLIO AO ENSINO DA GEOGRAFIA
Authors: Tôrres Lucas Matheus Garcia , Vieira Paulo Victor Menezes , Dantas Jerônico
Published: September 2024

O uso de novas metodologias no ensino de Geografia vem sendo um importante aliado no processo de ensino e aprendizagem. Dentro das novas formas de compartilhamento do conhecimento que encontra-se as Histórias em Quadrinhos – HQ’s. Pensando nisso, este estudo se debruçou na elaboração de uma história em quadrinho que visasse auxiliar o processo de ensino e aprendizagem em Geografia. Para tal, fez-se um estudo de gabinete para compreender a temática e ajudar na criação do roteiro da HQ intitulada de “Naty: em mudanças climáticas”. Em seguida aplicou-se a HQ nas aulas de Geografia da turma do 6º ano de uma escola pública no interior do Rio Grande do Norte e para finalizar viu-se a percepção dos alunos com relação ao uso da HQ no seu aprendizado. Como resultado podemos observar que a HQ se mostrou como importante ferramenta para auxiliar as aulas de Geografia, tanto no sentido de sair da monotonia das aulas comumente tradicionais aplicadas aos alunos, quanto na facilitação que estes apresentaram de entender o assunto trabalhado na HQ. Por fim, esperamos que a presente proposta metodológica sirva um novo recurso de cunho didático-pedagógico para os professores de Geografia.
RELAÇÕES SINÉRGICAS ENTRE EDUCAÇÃO E AGROECOLOGIA
Authors: De Albuquerque Araújo José Edson , Torres Filha Francisca Gomes , Torres Janine Beatriz , Da Silva Dias Nildo
Published: September 2024

Educação e agroecologia são duas categorias muito abrangentes e guardam em si – e entre si – possibilidades de ampliação de seus entendimentos. A educação é um componente essencial para reprodução dos conhecimentos gerados pela sociedade. Ao mesmo tempo, é espaço de construção, reflexão e reconstrução de saberes. A agroecologia – que, na realidade, transcende a lógica mecânica de produção – também se configura como um espaço de aprendizagem que une um aporte epistemológico e um modo de vida. Objetivando refletir sobre as convergências e as relações mútuas de fortalecimento entre essas duas grandes categorias, o artigo que segue, de modo mais específico, tem como intuito apresentar alguns dos grandes horizontes de reflexão proporcionados pela agroecologia e expor os espaços de convergência entre essas duas categorias. Sendo uma Revisão de Literatura Integrativa, com um universo temporal delimitado, majoritariamente, entre os anos de 2016 e 2021, com pesquisa realizada em fontes secundárias e com o uso das técnicas de skimming e scanning para a seleção de material, este trabalho pretende ser mais um instrumento de instigação à reflexão. A complementariedade que existe entre a educação e a agroecologia é nítida. Compreender esta intima associação possibilitou perceber que o resgate de conhecimentos das populações tradicionais associado às práticas de agricultores experimentadores e aos conhecimentos gerados nos ambientes de educação são condições necessárias a uma vida mais amplamente saudável. Todo esse conjunto aponta para um caminho possível e mais sustentável para a produção e reprodução da vida em seus mais diversos aspectos
PERCEPÇÃO SOCIOAMBIENTAL DO POTENCIAL TURÍSTICO DA REGIÃO GEOGRÁFICA IMEDIATA DE PRINCESA ISABEL – PB
Authors: Albuquerque Erickson Melo de , Souza Marinete dos Santos , Rodrigues Viana de Lima Eduardo
Published: September 2024

Esta pesquisa parte da premissa de que o desenvolvimento do turismo necessita da motivação, inclusão e participação de atores sociais que percebem o potencial turístico local. Sendo assim, objetivou-se avaliar aspectos socioambientais dessa percepção atinentes a dois grupos sociais da Região Geográfica Imediata de Princesa Isabel, caracterizada pelo baixo índice de desenvolvimento humano. Foram aplicados dois questionários semiestruturados: 1) a 5 gestores públicos municipais de turismo; e 2) a 173 famílias de 13 localidades da região. Observaram-se convergências e divergências nas respostas entre os dois grupos, todavia ambos percebem o potencial turístico local e identificam pontos positivos que indicam favorabilidade ao desenvolvimento do turismo, caso este seja implantado. Em síntese, avalia-se que há um potencial turístico na região a ser explorado com o apoio da população local.