bluuebunny/crossref_metadata_2025 huggingface dataset:
Kutane T-Zell Lymphome: Low-dose Gemcitabin in der Therapie fortgeschrittener CTCL
Authors: Blazejak Christoph , Assaf Chalid
Published: May 2022

Background: Gemcitabine is an effective single-agent chemotherapy used in advanced stages of cutaneous T-cell lymphoma (CTCL). However, gemcitabine used in the current standard regimen is frequently associated with adverse events (AE), such as an increased risk for myelosuppression and severe infections. Objectives: We investigated in this retrospective study the effect of low-dose gemcitabine in pretreated advanced-stage CTCL and in blastic plasmacytoid dendritic cell neoplasia (BPDCN) regarding overall response (OR), progression-free survival (PFS), and AE. Material and methods: A retrospective, multicenter study was conducted on 64 CTCL and BPDCN patients treated with gemcitabine in average absolute dosage of 1,800 mg/m2 per cycle, which is 50% lower compared to standard dosage of 3,600 mg/m2 per cycle (1,200 mg/m2 day 1, 8, 15). Evaluation of response to therapy and AE was done 4-6 weeks after the sixth cycle. Results: OR was 62% with 11% demonstrating a complete response. The median time of PFS was 12 months and median time to next treatment was 7 months. Only 3/63 patients showed serious side effects, e.g., port infection or acute renal failure. Almost 73% of the patients experienced minor to moderate side effects (CTCAE grade 0-2). Fatigue (27.2%), fever (22.7%), and mild blood count alteration (18.2%) were the most common AE. Conclusions: This retrospective analysis supports the use of low-dose gemcitabine therapy in CTCL, demonstrating with 62% OR and PFS of 12 months an almost identical response rate and survival as compared to the standard dose therapy reported in previous studies but with a significantly improved safety profile and tolerability.
A Clinical and Epidemiological Prevalence Study on Friedreich’s Ataxia in Latium, Italy
Authors: Romano Silvia , Bacigalupo Ilaria , Marcotulli Christian , Cioffi Ettore , Bertini Enrico Silvio , Vasco Gessica , Perna Alessia , Petrucci Antonio , Massa Roberto , Frezza Erica , Romano Carmela , Salvetti Marco , Ristori Giovanni , Silvestri Gabriella , Vanacore Nicola , Casali Carlo
Published: May 2022

Objective: The aim of this study was to estimate the Friedreich’s ataxia (FRDA) prevalence in a highly populated region of Italy (previous studies in small geographic areas gave a largely variable prevalence) and to define the patients’ molecular and clinical characteristics. Methods: For the point-prevalence study, we considered patients belonging to families with a molecular diagnosis of FRDA and resident in Latium on 1 January 2019. The crude prevalence of FRDA, specific for age and sex, was calculated and standardized for age using the Italian population. Moreover, we investigated possible correlations among patients’ genetic profile, symptoms, and age of onset. Results: We identified 63 FRDA patients; the crude prevalence for total, males, and females were 1.07 (95% CI: 0.81–1.37), 0.81 (95% CI: 0.54–1.22), and 1.32 (95% CI: 0.97–1.79), per 100,000 inhabitants. We divided FRDA patients by three age-at-onset groups (early-EOFA 73%; late-LOFA 11.1%; very late-VLOFA 15.9%) and found significant differences in the scale for the assessment and rating of ataxia (SARA; p = 0.001), a biased distribution of the shorter allele (p = 0.001), an excess of scoliosis and cardiomyopathy (p = 0.001) in EOFA. To determine the contribution of patients’ molecular and clinical characteristics to the annual rate of progression, we performed a multivariate regression analysis that gave an R2 value of 45.3%. Conclusions: We estimated the crude and standardized prevalence of FRDA in Latium. A clinical classification (EOFA, LOFA, VLOFA) gave significant correlations. This epidemiological estimate allows monitoring disease prevalence over time in cohort studies and/or for developing disease registry.
The Efficacy of Structural Priming in the Production of Sentences with Prepositions in Persian Patients with Poststroke Aphasia
Authors: Asadollahpour Faezeh , Khatoonabadi Ahmad Reza , Asadi Mozhgan , Darzi Ali , Mehri Azar
Published: May 2022

Introduction: Problems with the production of sentences with prepositions are one of the most common language problems in people with aphasia (PWA). Structural priming (SP) is one of the theory-based therapeutic approaches to improve these deficits. Although several studies have been conducted on the sentence construction problems of PWA, there is no study on the SP protocol for the production of sentences with Persian prepositions. This study aimed to investigate the effectiveness of SP in the production of these sentences among Persian-speaking PWA. Methods: This study, with a single-subject ABA design, evaluated the efficacy of SP in the production of trained and untrained sentences containing Persian prepositions in four aphasic individuals with agrammatism and investigated the maintenance effects at 4 weeks post-training. Results: Two subjects (A.G. and M.S.) showed notable changes in the production of trained sentences with Persian prepositions (50% to 91.67% for A.G. and 0% to 66.67% for M.S.). This significant improvement was generalized to sentences with untrained prepositions (50% to 91.67% for A.G. and 0% to 83.33% for M.S.). The treatment effects were also maintained in the 4-week follow-up (d2 = 10.3 for A.G. and d2 = 19.06 for M.S.). However, the other two participants only showed a slight increase in these variables after treatment. Conclusion: The findings of the present study revealed that SP for sentences with prepositions could be useful to varying degrees for Persian-speaking PWA with agrammatism and lead to improved language skills in producing these sentences. Overall, individuals with better language skills and cognitive status in early assessments showed better treatment outcomes than others.
Five new species of Yoyetta Moulds (Hemiptera: Cicadidae: Cicadettinae) from south-eastern Australia
Authors: POPPLE LINDSAY W. , EMERY DAVID L.
Published: May 2022

Five new species are described in the genus Yoyetta Moulds, each belonging to the Yoyetta tristrigata (Goding and Froggatt) species group. Yoyetta australicta n. sp. occurs in southern eucalypt woodlands in two separate populations, one extending from the foothills of the Mt Lofty Ranges and southern fringes of Adelaide north to the Flinders Ranges, and the other from Warrumbungle National Park and from Clandulla, near Orange and near Grenfell in New South Wales south to Mt Taylor in the Australian Capital Territory. Yoyetta corindi n. sp. has a restricted, coastal and subcoastal warm temperate distribution in north-eastern New South Wales open forest communities between Trustums Hill and Arrawarra, extending inland from south-west of Grafton to Tyringham. Yoyetta delicata n. sp. has an inland warm temperate distribution in eucalypt woodland and open forest from near Killarney and west of Warwick in south-east Queensland south to Cassilis and near Wyong in central New South Wales. Yoyetta ignita n. sp. is found from Flinders Peak and Mt Tamborine in south-east Queensland, south along the Great Dividing Range (and inland to Mt Kaputar) in New South Wales, with a disjunct population on the eastern slopes of Mt Ainslie in the Australian Capital Territory. Yoyetta robusta n. sp. is found from the Granite Belt in south-east Queensland south to the Glenn Innes area in northern New South Wales. The new species are all small–medium sized cicadas (15–25 mm body length) with male calling songs that are distinguishable from one another and from other species in the genus. In three of the new species (Y. australicta n. sp., Y. corindi n. sp. and Y. robusta n. sp.), the songs are characterised by sharp, high energy ticks or clicks, produced mainly in flight. Each of these species also produces ticks or clicks, sometimes in combination with a short buzz, while stationary. Of the remaining two species, one (Y. delicata n. sp.) produces a soft, coarse buzzing song while stationary and the other (Y. ignita n. sp.) produces a combination of buzzes and clicks while stationary. A key to species in the Y. tristrigata species group is provided.
Additional new species of the genus Hexarhopalus Fairmaire, 1891 (Coleoptera, Tenebrionidae: Cnodalonini) from China
Authors: JIANG RI-XIN , ZHOU QING-HUA , LIU YI-FENG , HUANG YU-ZHOU , CHEN XIANG-SHENG
Published: May 2022

Three new species of the genus Hexarhopalus Fairmaire, 1891, all of the nominate subgenus, are described and figured from China: Hexarhopalus (Hexarhopalus) ferreri sp. nov. from Yunnan, H. (H.) tianbaoyanensis sp. nov. from Fujian, and H. (H.) yeziyangi sp. nov. from Jiangxi.
Play Changes Us: Playing the Object, Becoming the Analyst
Authors: Corbett Ken
Published: May 2022

The manner in which play changes us is examined, with particular attention to the role of paradox. Sustaining paradox and illusory experiencing are held as key to the framework of psychoanalysis for patient and analyst alike. Particular attention is paid to the ways in which the analyst becomes a potential object of change through playing. The transitive hospitality of playing is examined in the treatment of a four-year-old boy, and in his resurrection of a near-dead mother and her neglected child. This treatment is examined in order to better understand the preoccupation of playing within illusion, as opposed to quickly naming play content. Playing is itself transformative, prior to any reflection or interpretation that may follow.
Perspectives and Influences on Occupation-Based Hand Therapy
Authors: Henrichon Kimberly A. , Toth-Cohen Susan E.
Published: May 2022

Background. Occupational therapists practicing hand therapy are challenged to implement occupation-based practices (OBPs) due to the strong influence of the medical model. Purpose. To explore hand therapists’ perceptions of OBP and describe occupation-based interventions (OBIs) in hand therapy. Method. Qualitative content analysis (QCA) was used to analyze semi-structured interviews with seven hand therapists. Findings. Six themes emerged: (1) OBP denotes treatment that is customized to ensure individual meaningfulness to each client; (2) the client–therapist relationship is a foundational element central to OBP in hand therapy; (3) goal setting serves as an important link between biomechanics and occupation; (4) OBP in hand therapy encompasses a spectrum of both OB and non-OB interventions; (5) various contextual factors influence OBI; (6) advanced experience in hand therapy facilitates enactment of tailored OBI. Implications. Comprehension of multiple aspects of occupation-based methods in hand therapy exemplifies best practices for clinicians to benefit clients and the profession's identity.
Binge-eating episode as a direct cause of death in a young individual without eating disorder
Authors: Cioffi Andrea , De Simone Stefania , Cipolloni Luigi , Baldari Benedetta
Published: May 2022

Binge eating is characterised by the ingestion of large quantities of food in a short time. Cases in the literature deal exclusively with gastric perforation in people with a history of anorexia nervosa, binge eating disorder or bulimia nervosa.

We report the case of a young woman with no previous diagnosis of mental illness and a history of only two binge-eating episodes that occurred a few years earlier. She died suddenly during a binge-eating episode from stomach rupture resulting from a single perforation of the stomach with leakage of food material within the abdominal cavity. There was no sign of gastric necrosis or peritonitis. The deceased died quickly.

Our case, which appears unique in the literature, shows that there is a risk of death even in people with no diagnosis of eating disorders and a history of only few and isolated binge-eating episodes. Physicians should carefully investigate a patient's history to assess any risks.
Jet diameter of the first coil in the electrospinning whipping region: the role of fluid viscosity
Authors: Lei Sailing , Wang Liming , Quan Zhenzhen , Qin Xiaohong , Yu Jianyong
Published: May 2022

In solution electrospinning, the ultrafine fiber is derived from the dramatic stretching of the whipping fluid jet. The first coil of the whipping fluid jet with the highest stretch rate plays a vital role in determining the microstructure and physical property of electrospun submicron/micron fibers. However, it still remains challenging to control precisely the stretching and jet diameter of the first coil of the whipping fluid jet. Herein, a comprehensive model for the jet diameter of the first coil of the whipping fluid jet is established, indicating that the jet diameter is a consequence of the balance between viscous and electrostatic forces, and is a function of the fluid viscosity, electric current, and flow rate. Furthermore, the stretch rate of the first coil of the whipping fluid jet is predicted, which decays as a scaling law with an exponent −1/2 along the axial direction. The theoretical predictions agree well with the experimental results. This work compensates for the deficiency of previous diameter models and enriches the mechanism of jet stretching, which can provide a valuable theoretical guide for the structural and functional design of submicron/micron fibers.
Sustainability of Healthcare Financing in Greece: A Relation Between Public and Social Insurance Contributions and Delivery Expenditures
Authors: Mavridoglou George , Polyzos Nikolaos
Published: May 2022

The economic crisis in Greece, which began in 2010 and lasted for 10 years, highlighted the serious problems and challenges of the Greek Social Health Insurance system. The reforms that mainly took place during the crisis provided a temporary solution. They focused on establishing a new National Organization for Healthcare Services (named EOPYY) and merging all the old insurance funds. This paper aims to examine whether this social health insurance fund has been sustainable in the long run. An actuarial model was created to project future expenses and revenues. Demographic and economic trends were considered, while it was assumed that medical technology remains unaltered. The assessment of the system solvency was based on the ratio (Revenue/Liabilities) calculated for each year, from 2020 to 2050. The results led to deficits, the amount and the time point in which they appear depends on how optimistic or pessimistic demographic and economic assumptions were. A new financial flow model was proposed to address the deficits. The results show that under the new model, the system remains solvent until 2050. The state subsidy amount on the employees’ health insurance premium was estimated as a percentage of the employees’ wage.
Public Employee Use of Social Media at Work: Competency, Collaboration, and Communication of Workplace Policy
Authors: Chansukree Pananda , Sagarik Danuvas , Cho Wonhyuk
Published: May 2022

Although the growth of social media has changed the way employees communicate at work, our understanding of the related workplace dynamics, particularly in public organizations, is still embryonic. This study fills these research gaps by testing hypotheses, drawn from social cognitive theory and social capital theory, using two sets of data on social media usage patterns and workplace practices among public employees. Our survey data ( n = 1,360) analysis revealed that most respondents (more than 72%) spent at least an hour per day on social media while at work, for both work- and non-work-related purposes. Furthermore, public employees with higher levels of social media competence (technical understanding and impact assessment) were more likely to report effective collaboration and seek assistance when needed. The results of scenario-based randomized survey experiment ( n = 600) show that the perceived fairness of social media-related termination decisions (or “get dooced”) was influenced by the presence of an explicit workplace social media policy.
A Walk in Thomas Annan’s Glasgow: Documentary Photography, Class and Urban Space
Authors: Rizov Vladimir
Published: May 2022

This text explores the photographic documentary work on the city of Glasgow by Thomas Annan in the mid- to late nineteenth century. I focus on Annan’s most well-known project— The Closes and Streets of Old Glasgow, 1868-1871, which remains the most significant urban focus in his work. I will begin by briefly outlining Annan’s position in the history of photography and the relation of his photographic work to the city of Glasgow. Subsequently, I will engage directly with the volume of interest and outline the character of the photographs. Finally, I will provide an analysis of Annan’s photographic work and the manner in which he contributed to a classed construction of the city of Glasgow through documentary photography. In particular, I will explore the images themselves through the lens of critical visual theory and relate them to the urban space of Glasgow itself.
Ludd and Lydda: A Tale of Two Plans
Authors: Da’adli Tawfiq
Published: May 2022

This article discusses a half century of urban transformation in one relatively minor town in Palestine, situated on a major road, under two regimes: the late Ottoman Empire and British Mandate. The changes in Ludd/Lydda are examined through the planning prism. Given the lack of any systematic, official planning in that town before World War I, an attempt is made to reconstruct such a plan out of available documents. Both the real plan one produced by the British colonial mind and the imagined one—produced so to speak by the Indigenous inhabitants as reconstructed here—serve as case study for tracing how the town’s Palestinian inhabitants coped with different regimes until their town was occupied by the Israeli military and they became refugees.
A Rare Case of Aggressive Metastatic Laryngeal Chondrosarcoma Presenting as Bilateral Necrotizing Pneumonia
Authors: Mirza Noreen , Veeraballi Sindhusha , Rayad Mohammad Nabil , Kamal Fatima , Shaaban Hamid , Lee Derek , Savopoulos Andreas
Published: May 2022

Laryngeal chondrosarcomas are rare tumors that account for only 0.2% of malignant tumors of the larynx. Approximately 80% of these tumors are low grade and well differentiated and are associated with a good long-term prognosis. Herein, we report a case of a 77-year-old male presenting with acute hypoxic respiratory failure that required intubation and mechanical ventilation. Chest CT showed multiple pulmonary nodules and cavities. He then required a tracheostomy, and a soft tissue mass in the subglottic mass was discovered. A laryngoscopy-guided excisional biopsy of the mass was performed. Histopathological examination confirmed the diagnosis of laryngeal chondrosarcoma. Clinicians should consider metastatic laryngeal chondrosarcoma as a differential diagnosis for lung cavities. Overall, we believe this to be the first case of aggressive laryngeal chondrosarcoma with mediastinal and pulmonary metastasis mimicking necrotizing pneumonia.
Ectopic Cervical Thymic Hyperplasia In A Patient Treated For Hodgkin Lymphoma
Authors: Achour Imen , Kallel Rim , Chaabouni Hela , Thabet Wadii , Mnejja Malek , Hammami Bouthaina , Boudawara Tahia , Chaabouni Mohamed Amine , Charfeddine Ilhem
Published: May 2022

True thymic hyperplasia results from stressful situations such as chemotherapy. It commonly presents as an anterior mediastinal mass; cervical location is exceptional. Here we report a case of a cervical true thymic hyperplasia in a 12-year-old girl who had a Hodgkin lymphoma treated by radiotherapy and chemotherapy. She was referred to our department for a left cervical mass. The PET scan showed a hypermetabolic adenopathy. Mediastinal MRI was unremarkable. The patient underwent resection of the cervical mass under general anesthesia. Pathological examination confirmed the diagnosis of a true thymic hyperplasia. The aim of this paper is to illustrate a case of an incidental ectopic cervical thymic hyperplasia in a patient treated for Hodgkin lymphoma.
Treatment Effect Heterogeneity
Authors: Smith Jeffrey
Published: May 2022

This paper considers recent methodological developments in the treatment effects literature, describes their value for applied evaluation work, and suggests next steps. It pays particular attention to documenting the presence of treatment effect heterogeneity, to the quest to attach treatment effect heterogeneity to particular subgroups and other moderators, and to the recent application of machine learning methods in this domain.
Perspectives: Revisited 2022-2
Authors: Kirkwood Hal
Published: May 2022

A review of articles across the Sage publications focusing on recent articles on the impact of COVID on financial instruction and on developments and implications in smart cities.
Evaluation of physician experience in achieving non-perfused volume ratio of high-intensity focused ultrasound ablation for uterine fibroids: a multicentre study
Authors: Gong Xue , Zhang Xinyue , Liu Dang , Yang Chao , Zhang Rong , Xiao Zhibo , Chen Wenzhi , Chen Jinyun
Published: May 2022

Objective

To evaluate the effect of different levels of physician experience on the high-intensity focused ultrasound (HIFU) ablation of uterine fibroids and to provide a reference for the use of non-perfused volume ratio (NPVR) standards during training.

Methods

This prospective multicentre study enrolled patients with uterine fibroids. The effect of the physician’s level of experience on the outcomes under different NPVR standards and the learning curve of six centres without HIFU experience were analysed. The impact of patient demographic and clinical characteristics were also evaluated.

Results

A total of 1352 patients from 20 centres were included in the study. The median NPVRs were 92.00%, 88.10% and 92.86% in the no experience group, inexperienced group and experienced group, respectively. Posterior wall fibroids, lateral wall fibroids and fundus fibroids were inversely correlated with NPVR, while experienced physicians were positively correlated with NPVR. With NPVR ≥ 70% and NPVR ≥ 80% standards, physicians in the no experience group completed the learning curve on the 11th and 16th procedure, respectively. Physicians under a standard of an NPVR ≥ 90% did not complete the learning curve.

Conclusions

NPVR ≥ 80% is a standard that is worth using for HIFU treatment of uterine fibroids.
Grain Trade, Climate Change and Famines: A Study of Awadh from c. 1858–1900
Authors: Singh Nalini
Published: May 2022

This study is based on an interesting debate between the British authorities and the Indian nationalists over the issues of frequent famines during the colonial period in India. The British officials largely emphasised the role of deficient rainfall behind the occurrence of famines. But the Indian nationalists saw these famines as an impact of the colonial policies like unequal redistribution of the food-grains available in the local markets as a trade item which led to the rise in prices of food grains and made it beyond the reach of the masses. In the nationalist approach, the man-made scarcity of food grains and the price rise of the same were the main reasons behind the famines. However, some British surveyors argued that the unplanned destruction and conservation of the forests for the capital accumulation not only led to irregular rainfall pattern which gradually affected agricultural output but also deprived the local masses from the benefits of forests especially during the famine period. Thus, the present article takes up some of the issues like rainfall pattern, deforestation, food grain production and grain trade to understand the occurrence of famines in the region of Awadh soon after the direct British rule over India since 1858, mainly using the official data of nineteenth century along with the secondary works.
The clinicopathological features of programmed death ligand-1 expression in colorectal carcinoma
Authors: Al-Jussani Ghada N. , Alsughayer Anas , Yousuf Mustafa S. , Mullahuwash Yaseen , Dabbagh Tamara , Sughayer Maher A.
Published: May 2022

Background

Few studies have addressed the clinicopathological features of colorectal cancer (CRC) that express programed death-ligand 1 (PD-L1). Various assays and scoring methodologies were used and thus inconsistent results were obtained. In this study, we aimed to investigate the relationship of PD-L1 expression in CRC with various clinicopathological variables using a standardized assay and scoring algorithm.

Design

Tissue microarrays were constructed from 91 random cases of CRC diagnosed at King Hussein Cancer Center (KHCC). Immunohistochemical (IHC) staining using the monoclonal antibody 22C3 was performed. Scoring using the standard “Combined Positive Score” (CPS) method was done. CPS of ≥1 was considered positive. Various clinicopathological features were collected from the medical records of the patients.

Results

Of the 91 cases, 49 (53.8%) were PD-L1 positive (CPS ≥1). PD-L1 expression was more frequent among moderately differentiated carcinomas (43 of 72 (59.7%) were positive compared to 6 of 19 (31.5%) poorly differentiated cases ( P = 0.029)); among node negative cases (21 of 24 (87.5%) N0 cases were PD-L1 positive in contrast to 28 of 67 (41.8%) N1/N2 cases ( P = <0.001)); among mucinous subtype (12 of 15 (80%) of cases ( P = 0.02)); and among mismatch repair deficient (dMMR) (16 of 16 (100%) versus 11 of 30 (36.6%) MMR proficient ( P = <0.001)). Age, gender, localization, and T or M stages were not significantly associated with PD-L1 expression.

Conclusion

PD-L1 expression in CRC is associated with favorable prognostic features; namely, lower grade, N0, mucinous variant, and dMMR tumors.
Two Emotional Design Features Are More Effective Than One in Multimedia Learning
Authors: Wang Xue , Mayer Richard E. , Han Meiqi , Zhang Lei
Published: May 2022

This study examined the impacts of adding emotional design features to a multimedia lesson (color alone, anthropomorphism alone, or color & anthropomorphism together) on college students’ affective processes (measured by ratings of experienced emotion during learning), cognitive processes (measured by eye-tracking metrics), and learning outcomes (measured by retention and transfer test scores). One-hundred students were randomly assigned to watch a short multimedia lesson in one of four conditions: no emotional design, colorful emotional design, anthropomorphism emotional design, and colorful and anthropomorphism emotional design. The study results showed that compared to the no emotional design group, the colorful and anthropomorphism emotional design group showed the higher positive emotion rating (d = .726), the shortest time to first fixation on an emotional design area ( d = - .877), the longest fixation duration on emotional design areas ( d = .640), and the best transfer test score ( d = .679). In contrast, the anthropomorphism emotional design group outperformed the no emotional design group only on rating of positive emotion, and the colorful emotional design group outperformed the no emotional design group only on transfer test score. The results show that two emotional design features are more effective than one in multimedia lessons. A structural equation model indicated that positive emotion (tapping affective processing) and fixation duration (tapping cognitive processing) mediated the pathway from emotional design to learning performance. These results partially support the Cognitive-Affective Model of E-Learning.
Optimal consensus control of multi-agent systems based on the state-dependent riccati equation
Authors: Geranmehr Behdad , Khanmirza Esmaeel
Published: May 2022

This paper is concerned with optimal consensus control of a multi-agent system, leaderless or leader-follower control. The hierarchical state-dependent Riccati equation (SDRE) controller was the main framework. The Lyapunov-based method is used for solving time-varying systems. Not only positive definite solution of the related algebraic Riccati equation is realized by the SDRE method based on Lyapunov, but also the negative definite solution is realized. Furthermore, the leader-follower tracking structure is developed based on two nonlinear differential equations; the feedforward differential equation and the state-dependent Riccati differential equation, which consider the error in the cost function through the co-sate equation. The application of the proposed controller structure in controlling the lifting system of multiple 3D cranes is studied. The theoretical results have been verified by simulating the leaderless and leader-follower consensus control problem.
Aerospace aspects of electromagnetohydrodynamic dusty flow of hybrid nanofluid with entropy generation over a rotating disk
Authors: Divya A. , Bala Anki Reddy P.
Published: May 2022

A lot of work has gone into developing a new generation of materials for aeronautical uses in recent years. In an aircraft engine, engine oil serves a variety of purposes, including lubrication, cooling, cleaning, corrosion protection, noise reduction and propeller operation. The most crucial is, of course, lubrication. Needless to say, all moving parts would quickly wear out if they were not lubricated. The goal of this initiative work is to reduce costs by prolonging the service life of aircraft parts (structural and engine components), as well as improving fuel efficiency, load capacity and flight range. The relevance of the electromagnetohydrodynamic dusty nanofluid over a rotating disk with entropy generation is discussed in this study. To convert the fluid transport equations into ordinary differential equations, suitable self-similarity variables are used and the Runge–Kutta fourth order with shooting technique is used to solve them. Graphs and tables depict the effects of active parameters on the fluid's transport qualities. Graphs for Bejan number, skin friction and Nusselt number are also performed. The fluid phase velocity and dust phase velocity rise as the electric field is increased whereas the tendency opposes a magnetic field. The temperature of both phases decreases with the rise in fluid particle interaction parameters for temperature and the rate of heat transfer rises for the electric field.
Proton pump inhibitor induced subacute cutaneous lupus erythematosus: Clinical characteristics and outcomes
Authors: Poh Yih Jia , Alrashid Abdulrahman , Sangle Shirish R , Higgins Eleanor , Benton Emma , McGibbon David , D’Cruz David P
Published: May 2022

Background

There is a growing literature reporting the association between proton pump inhibitor (PPI) use and subacute cutaneous lupus erythematosus (SCLE).

Aims

To compare the clinical characteristics of a cohort of patients with PPI-induced SCLE, their clinical course and treatment with a control group of primary SCLE patients not exposed to PPI.

Methods

We conducted a matched case–control study in a tertiary referral setting at the Louise Coote Lupus Unit. There were 64 SCLE patients: 36 with PPI-induced SCLE and 28 patients with primary SCLE.

Results

Twenty-six patients (72%) had pre-existing SLE in the PPI-induced SCLE group. Lower limb skin lesions were significantly more prevalent in the PPI group ( p < 0.0001). The prevalence of anti-Ro and anti-Ro-52 antibodies was numerically higher in the PPI group (64% and 60%), respectively, compared with 46% and 42% in the primary SCLE group. Peripheral blood eosinophils were normal in all patients in the PPI group. Thirteen patients underwent skin biopsy in the PPI group and 12 had histology in keeping with SCLE. The median time to presentation was 8 months with a median resolution period of 6 weeks. PPIs were stopped in 34 patients, while 2 patients continued treatment for other clinical indications. Twelve patients received concurrent oral corticosteroids. Two patients had severe SCLE in the form of Toxic Epidermal Necrolysis requiring critical care admission and were managed with corticosteroids, IV immunoglobulin and/or belimumab.

Conclusion

Lower limb involvement is a pointer to PPI-induced SCLE which is likely a class effect with all PPI.
Recognition of LGBTQI+ parent families across European borders
Authors: Bracken Lydia
Published: May 2022

The legal recognition of LGBTQI+ parent families differs considerably across Europe and is a matter that is largely outside of the remit of EU law. This creates difficulties for LGBTQI+ parent families who cross European borders as legal parent-child relationships established in one Member State may not be recognized in another, resulting in limping legal parentage. In the case of V.M.A. v. Stolichna obshtina, the CJEU found that where one EU Member State recognizes the legal parentage of same-sex parents, all other EU Member States must also recognize those parent-child relationships for the purpose of free movement. This article examines the significance and limitations of the decision.
Medicare-subsidised mental health services from the beginning of Better Access in 2006–2007 to 2019–2020: Descriptive analysis by state, profession and consultation profile
Authors: Looi Jeffrey C.L. , Maguire Paul A. , Allison Stephen , Bastiampillai Tarun
Published: May 2022

Objective

Since 2006, the Australian Federal Government has aimed at expanding mental healthcare through the ‘Better Access’ programme of Medicare-subsidised services by private practitioners. We comment on population access to subsidised mental health treatment via health professionals in Australia.

Methods

We descriptively analysed Australian Institute of Health and Welfare (AIHW) data.

Results

Increasing percentages of the Australian population of people received Medicare-subsidised services from 2008–09 to 2019–20. Population access to mental health treatment increased from 5.7% to 10.7%. In 2019–20, psychiatrists provided services for 1.7% of the population, while GPs provided for 8.8%, clinical psychologists 2.2%, registered psychologists 2.9%, and other allied health providers 0.4%. Over the period, numbers of Australian psychiatrists providing services increased, but the numbers of patients seen per year, and other indicators, have either been flat or declined. GP, Psychologist, Clinical Psychologist and other allied health consultations increased overall, but again the numbers of sessions have decreased.

Conclusions

Medicare-subsidised private practice has greatly increased population access to mental health treatment. However, there appear to be a relatively limited number of consultations per patient for most provider groups. Further research is required on the effectiveness of treatment through collecting data on casemix and outcomes.
Elite Selection in Single-Party Autocracies: Minimizing Protests and Counterproductive State Violence to Maintain Social Stability
Authors: Mirić Siniša , Pechenkina Anna O.
Published: May 2022

Why are some but not other officials selected for promotion in single-party regimes? Understanding inner-elite dynamics of these regimes is important for explaining their resilience. Recent evidence suggests that these polities prioritize patronage connections over competence, when deciding who receives advancement at the top echelons of power hierarchy. By contrast, this paper proposes that, besides patronage, competence (demonstrated as an official’s ability to maintain social stability) also contributes to the promotion of top officials. While it is widely acknowledged that social stability is a key concern for autocracies, prior quantitative research on career outcomes of single-party elites has largely ignored this criterion for promotion. We argue that evaluating officials based on their ability to minimize protests demonstrates another dimension of competence (in addition to economic growth) that is designed to address the problem of authoritarian control, that is, managing popular discontent. We test this argument in the context of China, using a sample of 116 party secretaries in 2003–2017 who faced a total of 10,085 labor protests. Our findings are consistent with this argument.
Mental Health Seeking Behavior Among Muslims in The United States of America
Authors: Sabado Jhoevhana A. , Tram Jane M. , Khan Anam N. , Lopez Jacquelene M.
Published: May 2022

Since the 9/11 terrorist attacks, Muslims in the United States of America (MIA) have experienced increasing encounters with discrimination, hate crimes, and violence. This places them a higher risk for mental health symptoms. Although current research explores factors that impact mental health seeking behaviors of ethnic and racial minorities, there is a paucity of research examining the utilization of mental health services among religious minorities. The purpose of our study was to examine the relations between acculturation to Islamic values, acculturation to American values, and mental health seeking behaviors of MIA. We also sought to identify sources of support MIA utilize when experiencing religious adversity. We had three findings. First, we found a significant negative relation between Islamic values and likelihood of seeking mental health services. In other words, MIA who adhered to more Islamic values were less likely to seek mental health treatment. Second, we found a significant positive relation between acculturation to American values and the likelihood of seeking mental health services. Thus, MIA who were more acculturated to American values were more likely to seek mental health services compared to MIA who were less acculturated. Third, we found that the top ranked sources of support for MIA were family, self-care, religion (e.g., prayer), or not seeking support at all. MIA in our study were less likely approach friends, community (e.g., mosque), or professionals (e.g., therapy). The implications of our findings are discussed.
Immunohistochemistry for FOSB and FOS is a Useful Ancillary Tool in the Diagnosis of Epithelioid Hemangioma but There are Pitfalls in Interpretation Including Expression in Other Vascular Lesions
Authors: Tsui Kwan Yee , Maclean Fiona , Moir Denis , Cheah Alison , Bonar Fiona , Tabot Joel , Gill Anthony J. , Vargas A. Cristina
Published: May 2022

Introduction. Epithelioid hemangioma is a benign vascular neoplasm associated with FOS and/or FOSB protein overexpression detected by immunohistochemistry (IHC). Methods. The aim of our study was to determine the co-expression or independent IHC expression of FOS and FOSB in a cohort of epithelioid hemangiomas. We also included two cohorts of other vascular lesions: papillary endothelial hyperplasia and lobular capillary hemangioma / pyogenic granuloma. Results. We identified 50 cases of epithelioid hemangioma, 84% of which were cutaneous and the remaining involved other anatomic locations. Over two thirds of all cases expressed FOSB (68%; 34/50) while FOS immunoreactivity was identified in 46% of all cases. Co-expression of FOSB and FOS occurred in 37% of cases while 76% of all cases stained for at least one of the antibodies. Fifty-eight percent (n = 14/24) and 33% (8/24) of all cases of papillary endothelial hyperplasia expressed FOS and FOSB, respectively. Thirty-two per cent of lobular capillary hemangiomas (n = 8/25) were positive for either FOS or FOSB. Conclusion. In summary, we present the largest cohort of epithelioid hemangiomas assessed with both FOS and FOSB and demonstrated that the use of both antibodies increases the detection rate of these proliferations by 10%. Nonetheless, the use of thresholds may not be appropriate, as only a subset of lesional endothelial cells label with FOS/FOSB. Over half of all cases of papillary endothelial hyperplasia and a third of lobular capillary hemangiomas also displayed immunoreactivity with FOS and/or FOSB.
Gastric Perineurioma: A Case Report and Review of the Literature
Authors: Huber Aaron R. , DeRoche Tom C.
Published: May 2022

Perineuriomas of the gastrointestinal tract, formerly known as benign fibroblastic polyps, most commonly occur as polyps on screening colonoscopy, particularly in the distal colon. Gastric examples are exceedingly rare. We report the sixth patient with a gastric perineurioma in a 57-year-old female. Histologically, the lesion was composed of bland spindle cells without cytologic atypia or mitotic activity located in the gastric lamina propria. The spindled cells were strongly positive for GLUT1 and focally reactive for epithelial membrane antigen (EMA). The morphologic and immunophenotypic findings were those of gastric perineurioma.
Polypoid-Type Adenomyomatous Lesion of the Cystic Duct: Report of a Case and Review of Literature
Authors: Utsumi Yoshitaka , Miyai Kosuke , Sato Chikako , Nishiyama Kiyoshi , Murayama Michinori , Takeo Hiroaki
Published: May 2022

Adenomyomatous hyperplasia, a common non-neoplastic lesion in the gallbladder, is rarely identified in the extrahepatic bile duct. Typically, these lesions appear as a nodule or mural thickening/elevation. However, in exceptional circumstances, pedunculated/polypoid adenomyomatous lesion occurs in the biliary tract; two cases in the gallbladder and only one case in the common bile duct have been reported. Despite their benign nature, adenomyomatous lesions, especially those with a polypoid appearance, are clinically difficult to exclude a possibility of malignant neoplasms. We describe a case of polypoid-type adenomyomatous lesion of the cystic duct in a 72-year-old man, which was considered as a cystic duct neoplasm preoperatively. Gross examination of the resected specimen revealed that the 9 mm-sized cystic duct polyp. Histologically, the polypoid lesion consisted of glands without atypia, fibrous stroma, smooth muscle bundles, and accompanying stromal inflammation, leading to the diagnosis of benign adenomyomatous lesion. The lesion might be considered as adenomyomatous hyperplasia arising in the valve of Heister, while true nature of the lesion is uncertain. Recognition and accumulating for this rare disease will contribute to better clinical management in the future.
Influence of added whey proteins and hydrolysates on rheological and textural characteristics of milk chocolate
Authors: Rakin Marica , Bulatović Maja , Zarić Danica , Krunić Tanja , Lončarević Ivana , Petrović Jovana , Pajin Biljana
Published: May 2022

In order to improve functional characteristics of standard milk chocolate (C) was enriched by the addition of whey protein concentrate (WPC) and whey proteins hydrolyzed by trypsin (H-WPC) in the amount of 6%. The chocolate samples were analyzed by determination of antioxidant capacity, particle size distribution, textural, rheological, and sensory properties. The obtained results revealed that chocolate enriched by whey protein hydrolysate (H-WPC) possesses higher content of total polyphenols (1007.8 ± 96.8 mg GAE/100 g), increased ability to inhibit ABTS radicals (66.30 ± 1.99%), and increased ability to inhibit DPPH radicals (56.34 ± 3.20%), compared to the standard milk chocolate (C) (877.1 ± 56.0 mg GAE/100g; 48.46 ± 2.11%; 48.07 ± 2.80%, respectively). The additional ingredients do not significantly affect the hardness and enthalpy of chocolates. The hydrolyzed whey proteins increase the viscosity of chocolate (11.81 ± 0.11 Pa·s) to a greater extent than non-hydrolyzed whey proteins (9.17 ± 0.09 Pa·s), relative to the control sample (3.53 ± 0.05 Pa·s). Regardless of the fact that the WPC sample has slightly better rheological characteristics and particle size distribution compared to the H-WPC sample, no major changes in the sensory characteristics of chocolate were observed. Based on the results, whey protein hydrolysate can be marked as an exceptional ingredient for improving the quality of chocolate.
“Keep Your Wheels Off the Furniture”: The Marginalization of Street Skateboarding in the City of Melbourne’s “Skate Melbourne Plan”
Authors: O’Keeffe Patrick , Jenkins Lulu Fawdon
Published: May 2022

The City of Melbourne’s Skate Melbourne Plan purports to be skateboarder-centered, focusing on developing skate spaces for skateboarders. Drawing on research analyzing street skateboarders’ production of space and the importance of public spaces to street skateboarding, we examine how the Skate Melbourne Plan recognizes and supports street skateboarders’ capacity to skate in city environments. We suggest that rather than developing street skateboarding in the Melbourne Central Business District (CBD), the Skate Melbourne Plan reproduces negative constructions of young people who engage in street skateboarding as deviant and delinquent, by marginalizing and delegitimizing street skateboarding in public spaces.
Deathlogging: GoPros as forensic media in accidental sporting deaths
Authors: Gilmore James N
Published: May 2022

This article develops the concept of ‘deathlogging’ as a complement to the more popular ‘lifelogging’ to describe how wearable cameras record fatal accidents, particularly among action sports participants. The article situates deathlogging in a history of media and communication theory interested in the relationships between life and death, and in particular the concept of forensic mediation to describe technologies capable of documenting and reconstructing accidents. The wearable GoPro camera is a camera of choice for action sports athletes to easily record and share things like BASE jumping to gain audience views and capital in the form of sponsorships. Representative examples are discussed and analyzed to demonstrate how fatal accidents transform the value of GoPro footage from social-economic capital into forensic or juridical evidence to reconstruct accidents, make sense of fatalities, and, in some instances, argue for legal culpability. The article offers deathlogging as a concept which can be applied to a variety of recording situations with different kinds of wearable cameras.
Operating room waste management: A case study of primary hip operations at a leading National Health Service hospital in the United Kingdom
Authors: Pegg Melissa , Rawson Rebecca , Okere Uchechukwu
Published: May 2022

Objective

This research examines current waste management within an operating room at a large United Kingdom National Health Service (NHS) hospital. The study measured the volume and type of waste produced for primary hip operations (PHOs) and estimated the total waste produced across the United Kingdom by the procedure.

Methods

Three PHOs were audited to measure and compare the waste volumes generated.

Results

The average volume of waste per surgical procedure was 10.9 kg, consisting of clinical (84.4%), recyclable (12.8%) and bio-bin (2.8%) waste. This research also found that single-use devices contribute significantly to operating room waste. In addition, it was estimated that there is a missed opportunity to reduce clinical waste volume in each procedure, where approximately 15% of clinical waste disposal consisted of visibly clean recyclable waste material, including cardboard and plastics.

Conclusions

It was estimated that in the NHS approximately 1043 tonnes of waste is produced annually by PHOs alone. A significant volume of this waste could be prevented through improved recycling and reduced use of single-use devices.
Brothers from another mother: Seeing the uncanny in US popular media depictions of South Africa
Authors: van der Merwe Rachel Lara
Published: May 2022

This article examines a pattern of popular US audiovisual media depictions of post-apartheid South Africa, which portray SA as harbouring latent danger. I use these depictions as an entry point into a broader web of articulation that connects various theoretical lenses (including Othering and theories of fear), empirical data, and historical context in order to tell a conjunctural story about the precarity of US exceptionalism and Whiteness. Rather than reading these depictions as a suggestion that SA is a tangible threat of danger to the world, I argue that the strategic formation of these depictions reveals how the US experiences the uncanny (familiar unfamiliar) in SA, another significantly White settler-colonial state, and thus perceives a discursive threat of SA democracy to US exceptionalism on the global stage. This conjuncture, I suggest, reveals a discursive struggle over multicultural global futures and who gets to define democracy in the popular imagination.