bluuebunny/crossref_metadata_2025 huggingface dataset:
An optimized LC-HRMS untargeted metabolomics workflow for multi-matrices investigations in the three-spined stickleback
Authors: Lebeau-Roche Emmanuelle , Daniele Gaëlle , Fildier Aurélie , Turies Cyril , Dedourge-Geffard Odile , Porcher Jean-Marc , Geffard Alain , Vulliet Emmanuelle
Published: November 2021

Environmental metabolomics has become a growing research field to understand biological and biochemical perturbations of organisms in response to various abiotic or biotic stresses. It focuses on the comprehensive and systematic analysis of a biologic system’s metabolome. This allows the recognition of biochemical pathways impacted by a stressor, and the identification of some metabolites as biomarkers of potential perturbations occurring in a body. In this work, we describe the development and optimization of a complete reliable methodology based on liquid chromatography coupled to high resolution mass spectrometry (LC-HRMS) for untargeted metabolomics studies within a fish model species, the three-spined stickleback (Gasterosteus aculeatus). We evaluated the differences and also the complementarities between four different matrices (brain, gills, liver and whole fish) to obtain metabolome information. To this end, we optimized and compared sample preparation and the analytical method, since the type and number of metabolites detected in any matrix are closely related to these latter. For the sample preparation, a solid-liquid extraction was performed on a low quantity of whole fish, liver, brain, or gills tissues using combinations of methanol/water/heptane. Based on the numbers of features observed in LC-HRMS and on the responses of analytical standards representative of different metabolites groups (amino acids, sugars…), we discuss the influence of the nature, volume, and ratio of extraction solvents, the sample weight, and the reconstitution solvent. Moreover, the analytical conditions (LC columns, pH and additive of mobile phases and ionization modes) were also optimized so as to ensure the maximum metabolome coverages. Thus, two complementary chromatographic procedures were combined in order to cover a broader range of metabolites: a reversed phase separation (RPLC) on a C18 column followed by detection with positive ionization mode (ESI+) and a hydrophilic interaction chromatography (HILIC) on a zwitterionic column followed by detection with negative ionization mode (ESI-). This work provides information on brain, gills, liver, vs the whole body contribution to the stickleback metabolome. These information would help to guide ecotoxicological and biomonitoring studies.
Providers’ mediating role for medication adherence among cancer survivors
Authors: Trogdon Justin G. , Amin Krutika , Gupta Parul , Urick Benjamin Y. , Reeder-Hayes Katherine E. , Farley Joel F. , Wheeler Stephanie B. , Spees Lisa , Lund Jennifer L.
Published: November 2021

Background

We conducted a mediation analysis of the provider team’s role in changes to chronic condition medication adherence among cancer survivors.

Methods

We used a retrospective, longitudinal cohort design following Medicare beneficiaries from 18-months before through 24-months following cancer diagnosis. We included beneficiaries aged ≥66 years newly diagnosed with breast, colorectal, lung or prostate cancer and using medication for non-insulin anti-diabetics, statins, and/or anti-hypertensives and similar individuals without cancer from Surveillance, Epidemiology, and End Results-Medicare data, 2008–2014. Chronic condition medication adherence was defined as a proportion of days covered ≥ 80%. Provider team structure was measured using two factors capturing the number of providers seen and the historical amount of patient sharing among providers. Linear regressions relying on within-survivor variation were run separately for each cancer site, chronic condition, and follow-up period.

Results

The number of providers and patient sharing among providers increased after cancer diagnosis relative to the non-cancer control group. Changes in provider team complexity explained only small changes in medication adherence. Provider team effects were statistically insignificant in 13 of 17 analytic samples with significant changes in adherence. Statistically significant provider team effects were small in magnitude (<0.5 percentage points).

Conclusions

Increased complexity in the provider team associated with cancer diagnosis did not lead to meaningful reductions in medication adherence. Interventions aimed at improving chronic condition medication adherence should be targeted based on the type of cancer and chronic condition and focus on other provider, systemic, or patient factors.
Optimizing nitrogen fertilizer amount for best performance and highest economic return of winter wheat under limited irrigation conditions
Authors: Zhang Pin , Qi Yi-kang , Wang Hong-guang , He Jian-ning , Li Rui-qi , Liang Wei-li
Published: November 2021

Inappropriate water and fertilizer management can lead to unstable crop yields. Excessive fertilization can potentially cause soil degradation and nitrogen (N) leaching. The aim of this study was to explore the optimal N application rate on two wheat varieties with different nitrogen responding under limited water irrigation at three experimental sites in the Piedmont plain of the Taihang Mountains, China. A two-year field experiment was conducted to explore the effects of five N application rates (N0, N120, N180, N240, and N300) on winter wheat growth, leaf area index, aboveground biomass, grain yield, grain N accumulation, and net return. The results showed that N application rate significantly affected leaf area index, aboveground biomass, grain yield, and harvest index. Variety and variety × N rate interactions had a significant effect on few indicators. Compared with N0, N180 improved leaf area index, aboveground biomass, grain yield, and grain N accumulation. Compared with N240 and N300, N180 increased the harvest index and N harvest index, without significantly reducing grain yield or grain N accumulation, while enhancing a higher N use efficiency. Fertilizers applied in the ranges of 144.7–212.9 and 150.3–247.0 kg ha-1 resulted in the highest net return for the KN199 and JM585 varieties, respectively. Our study provides a sound theoretical basis for high-efficiency fertilizer utilization in sustainable winter wheat production in the Piedmont plains of the Taihang Mountains of China.
Antibiotic use for respiratory syncytial virus in the Middle East: A surveillance study in hospitalized Jordanian children
Authors: Rankin Danielle A. , Khankari Nikhil K. , Haddadin Zaid , Hamdan Olla , Yanis Ahmad , Faouri Samir , Shehabi Asem , Williams John V. , Khuri-Bulos Najwa , Halasa Natasha B.
Published: November 2021

Introduction

In developing countries where point-of-care testing is limited, providers rely on clinical judgement to discriminate between viral and bacterial respiratory infections. We performed a cross-sectional cohort study of hospitalized Jordanian children to evaluate antibiotic use for respiratory syncytial virus (RSV) infections.

Materials and methods

Admitting diagnoses from a prior viral surveillance cohort of hospitalized Jordanian children were dichotomized into suspected viral-like, non-pulmonary bacterial-like, and pulmonary bacterial-like infection. Stratifying by sex, we performed a polytomous logistic regression adjusting for age, underlying medical condition, maternal education, and region of residence to estimate prevalence odds ratios (PORs) for antibiotic use during hospitalization. Sensitivity and specificity of admission diagnoses and research laboratory results were compared.

Results

Children with a suspected viral-like admission diagnosis, compared to those with suspected non-pulmonary bacterial-like, were 88% and 86% less likely to be administered an empiric/first-line antibiotic (male, aPOR: 0.12; female, aPOR: 0.14; p-value = <0.001). There were slight differences by sex with males having a lower prevalence than females in being administered an expanded coverage antibiotic; but they had a higher prevalence of macrolide administration than males with non-pulmonary bacterial-like infection. Overall, children with RSV had a 34% probability (sensitivity) of being assigned to a suspected viral-like diagnosis; whereas RSV-negative children had a 76% probability (specificity) of being assigned to a suspected pulmonary bacterial-like diagnosis.

Conclusions

Hospitalized children with a suspected viral-like admission diagnosis were less likely to receive an empiric/first-line and expanded coverage antibiotic compared to suspected non-pulmonary and pulmonary infections; however, when evaluating the accuracy of admission diagnosis to RSV-laboratory results there were considerable misclassifications. These results highlight the need for developing antibiotic interventions for Jordan and the rest of the Middle East.
Object detection for automatic cancer cell counting in zebrafish xenografts
Authors: Albuquerque Carina , Vanneschi Leonardo , Henriques Roberto , Castelli Mauro , Póvoa Vanda , Fior Rita , Papanikolaou Nickolas
Published: November 2021

Cell counting is a frequent task in medical research studies. However, it is often performed manually; thus, it is time-consuming and prone to human error. Even so, cell counting automation can be challenging to achieve, especially when dealing with crowded scenes and overlapping cells, assuming different shapes and sizes. In this paper, we introduce a deep learning-based cell detection and quantification methodology to automate the cell counting process in the zebrafish xenograft cancer model, an innovative technique for studying tumor biology and for personalizing medicine. First, we implemented a fine-tuned architecture based on the Faster R-CNN using the Inception ResNet V2 feature extractor. Second, we performed several adjustments to optimize the process, paying attention to constraints such as the presence of overlapped cells, the high number of objects to detect, the heterogeneity of the cells’ size and shape, and the small size of the data set. This method resulted in a median error of approximately 1% of the total number of cell units. These results demonstrate the potential of our novel approach for quantifying cells in poorly labeled images. Compared to traditional Faster R-CNN, our method improved the average precision from 71% to 85% on the studied data set.
Skeleton binding protein-1-mediated parasite sequestration inhibits spontaneous resolution of malaria-associated acute respiratory distress syndrome
Authors: Possemiers Hendrik , Pham Thao-Thy , Coens Marion , Pollenus Emilie , Knoops Sofie , Noppen Sam , Vandermosten Leen , D’haese Sigrid , Dillemans Luna , Prenen Fran , Schols Dominique , Franke-Fayard Blandine , Van den Steen Philippe E.
Published: November 2021

Malaria is a hazardous disease caused byPlasmodiumparasites and often results in lethal complications, including malaria-associated acute respiratory distress syndrome (MA-ARDS). Parasite sequestration in the microvasculature is often observed, but its role in malaria pathogenesis and complications is still incompletely understood. We used skeleton binding protein-1 (SBP-1) KO parasites to study the role of sequestration in experimental MA-ARDS. The sequestration-deficiency of these SBP-1 KO parasites was confirmed with bioluminescence imaging and by measuring parasite accumulation in the lungs with RT-qPCR. The SBP-1 KO parasites induced similar lung pathology in the early stage of experimental MA-ARDS compared to wildtype (WT) parasites. Strikingly, the lung pathology resolved subsequently in more than 60% of the SBP-1 KO infected mice, resulting in prolonged survival despite the continuous presence of the parasite. This spontaneous disease resolution was associated with decreased inflammatory cytokine expression measured by RT-qPCR and lower expression of cytotoxic markers in pathogenic CD8+T cells in the lungs of SBP-1 KO infected mice. These data suggest that SBP-1-mediated parasite sequestration and subsequent high parasite load are not essential for the development of experimental MA-ARDS but inhibit the resolution of the disease.
M-Sec induced by HTLV-1 mediates an efficient viral transmission
Authors: Hiyoshi Masateru , Takahashi Naofumi , Eltalkhawy Youssef M. , Noyori Osamu , Lotfi Sameh , Panaampon Jutatip , Okada Seiji , Tanaka Yuetsu , Ueno Takaharu , Fujisawa Jun-ichi , Sato Yuko , Suzuki Tadaki , Hasegawa Hideki , Tokunaga Masahito , Satou Yorifumi , Yasunaga Jun-ichirou , Matsuoka Masao , Utsunomiya Atae , Suzu Shinya
Published: November 2021

Human T-cell leukemia virus type 1 (HTLV-1) infects target cells primarily through cell-to-cell routes. Here, we provide evidence that cellular protein M-Sec plays a critical role in this process. When purified and briefly cultured, CD4+ T cells of HTLV-1 carriers, but not of HTLV-1- individuals, expressed M-Sec. The viral protein Tax was revealed to mediate M-Sec induction. Knockdown or pharmacological inhibition of M-Sec reduced viral infection in multiple co-culture conditions. Furthermore, M-Sec knockdown reduced the number of proviral copies in the tissues of a mouse model of HTLV-1 infection. Phenotypically, M-Sec knockdown or inhibition reduced not only plasma membrane protrusions and migratory activity of cells, but also large clusters of Gag, a viral structural protein required for the formation of viral particles. Taken together, these results suggest that M-Sec induced by Tax mediates an efficient cell-to-cell viral infection, which is likely due to enhanced membrane protrusions, cell migration, and the clustering of Gag.
¿Veo mi puerto? Reconversión logística y producción de límites cognitivos en el puerto de Valparaíso
Authors: Budrovich Jorge
Published: November 2021

La reconversión logística del mundo portuario de Valparaíso – enclave histórico del comercio marítimo del pacífico sur – ha planteado diferendos, brechas y obstáculos de índole social y cultural que repercuten en las proyecciones de la ciudad, de sus habitantes y de los actores del mundo portuario. El presente artículo esboza la categoría de “producción de límites cognitivos” con el propósito de mostrar el conflicto de representaciones que supone este proceso de reestructuración y su relevancia para posibilitar un dialogo productivo entre las diferentes partes interesadas.
Evaluation of the phytochemical content, antimicrobial and antioxidant activity of Cocos nucifera liquid smoke, Garcinia mangostana pericarp, Syzygium aromaticum leaf, and Phyllanthus niruri L. extracts
Authors: Pasaribu Tiurma , Sinurat Arnold P. , Wina Elizabeth , Cahyaningsih Triwardhani
Published: November 2021

Background and Aim: Many plants contain bioactive substances with antibacterial and antifungal properties. The aim of this study was to evaluate the antibacterial and antifungal activity of Cocos nucifera shell liquid smoke (CSL), clove leaf extract (CLE), and mangosteen pericarp extract (MPE) alone and in combination against Escherichia coli and Candida utilis. The antioxidant activity, phenol, saponin, and tannin of CSL, CLE, MPE, and Phyllanthus niruri L. extract were also measured.

Materials and Methods: The agar well-diffusion method was used to determine the antimicrobial and antifungal activities of CSL, methanolic MPE, and CLE and their combination CSL+MPE+CLE (COMBI) on bacteria E. coli and fungus (C. utilis). Antioxidant activity was measured by the diphenylpicrylhydrazyl method. Total phenol and total tannin were measured by the Folin–Ciocalteu method and total saponin was measured by the vanillin-sulphate method.

Results: The results indicated that phenolic and tannin levels were greater in MPE than in CLE, whereas the saponin content was higher in CLE compared with MPE. Undiluted (100%) MPE exhibited lower antibacterial activity (p<0.05) than chloramphenicol against E. coli, however, undiluted CLE and COMBI showed similar activity compared with chloramphenicol against E. coli. COMBI caused significantly (p<0.05) higher inhibition compared with virginiamycin against E. coli. CSL, MPE, and COMBI exhibited significantly lower antifungal activity (p<0.05) than that of ketoconazole against C. utilis. In contrast, CLE showed improved antifungal activity (p<0.05) compared with ketoconazole.

Conclusion: Cocos nucifera liquid smoke, Garcinia mangostana pericarp extract, and Syzygium aromaticum leaf extract, either alone or in combination, have the potential to be used as antibacterial and antifungal agents.
TRENDS AND DETERMINANTS OF DEMOGRAPHIC PROCESSES IN RUSSIA
Authors: Grishina E. N. , Lapteva I. P.
Published: November 2021

The article substantiates the need to identify trends in the development of processes demographic in individual countries and regions. The analysis of the determination of demographic processes is a necessary condition for the development of an effective demographic policy. The authors studied the dynamics of the population of the planet as whole, Europe, and Russia over the past 50 years. The assessment of the degree of influence of the measures taken in certain countries of the world on the demographic situation is given. The article deals with both methodological issues of studying the determination of demographic processes, and the results of research based on statistical information. Much attention is paid to the issues of determining the birth rate and mortality. An assessment of the impact of material payments on the birth rate is given. At the same time, the issues of determining migration processes and population aging are not left without attention. To analyze the causes of population migration in the region, the experimental planning method was used. The use of this method allowed us to identify the factors that affect migration processes and to assess the degree of influence of each of them on the level of the migration efficiency coefficient. The study showed the possibility of using the planning method in the study of socio-economic processes. The authors consider three variants of the population forecast of the Russian Federation until 2035, proposed by Rosstat, and assessed possible options for their implementation.
TRENDS AND FACTORS IN THE DEVELOPMENT OF THE AGRO-INDUSTRIAL COMPLEX ALTAI REGION IN THE REGION'S ECONOMIC SECURITY SYSTEM
Authors: Semikolenova M. N. , Semina L. A. , Zemlyakova S. N.
Published: November 2021

In the context of a dynamically developing competitive market, global changes in production and the distribution of production resources, the increasing influence of political and socio-economic factors, the issues of ensuring the economic security of both the region and the industries included in its economy acquire special relevance. Agriculture is, on the one hand, the most vulnerable sector of the economy and is influenced by many factors, but, on the other hand, the most significant for the sustainable development of the Altai Territory. The study concluded that it is highly competitive and dependent in food security in other regions of the Siberian Federal District and the dynamics of development of the agro-industrial complex of the region. However, there are threats to economic security, the presence of which impedes the effective functioning of the agro-industrial complex. Based on the study, the main risks and threats have been identified that are of the greatest importance for the economic security of agriculture in the Altai Territory: a low level of investment activity, deterioration of agricultural machinery, a shortage of qualified personnel, risks of natural factors.
SPATIAL STUDIES IN THE RUSSIAN REGIONALISTS WORKS: A NARRATIVE REVIEW
Authors: Trotskovsky A. Ya.
Published: November 2021

The purpose of this article is to streamline relatively new (over the last ten-year period) information in the field of regional and spatial research for a better understanding of the subject field of regionalistics. The article was implemented in the form of a review as one of the promising types of scientific publication and generally meets international criteria and the traditions of their compilation.

Taking into account the initial stage of the study of the socio-economic space among the extensive typology of reviews used in international practice, the most common appearance is a narrative review, one of whose characteristic features is subjective selection of information.

Preference in selection of articles was given to the works of famous regionalists; At the same time, not only publications, “directly” reflect the trends in the development of socio-economic space, but also studies made by conjugate topics and disciplines.

Structuring articles were carried out on various reasons. The main grouping of publications: 1) in the context of scientific schools and personalities; 2) depending on the direction of publications disclosing certain trends in the development of socio-economic space (“differentiation — leveling” differences, “compression — expansion”, “Integration — fragmentation”).

The complexity and problems of the formation of regional and spatial research reviews are revealed, promising directions for analyzing information on spatial subjects associated with the preparation of a systematic review are shown.
BEHAVIOR OF DOUBLE SKIN FLAT COMPOSITE WALL UNDER LATERAL LOAD
Authors: Dasi Cezar
Published: November 2021

Shear walls are the primary lateral load-carrying elements in tall buildings. The composite shear walls with double steel plates and filled concrete are composed of two steel plates with studs inside, they were developed to enlarge the building space, and to delay the appearance of cracks by using the steel plates as formwork. Double skin composite wall panels can offer high strength and robustness while improving the convenience of construction, with great potential for application in nuclear power plants
A Rare Case of Waldenstrom Macroglobulinemia of the Rectosigmoid Colon
Authors: Zelman Sara , Russell Michael B. , Hojat Amin , Pilichowska Monika , Olans Lori B. , Sterling Mark J.
Published: November 2021

Waldenstrom macroglobulinemia is an uncommon mature B-cell lymphoma characterized by monoclonal immunoglobulin M protein in peripheral blood and lymphoplasmacytic cells in bone marrow and/or extramedullary sites. The gastrointestinal tract is a rare site of involvement. The diagnosis is based on clinicopathologic findings, although somatic mutations, such as MYD88, can aid in the diagnosis. We present a patient with irregular stools diagnosed with Waldenstrom macroglobulinemia involving the rectosigmoid colon by histopathology and immunohistochemistry on colonic biopsies, immunoglobulin M protein in serum, clonal plasma cells in bone marrow, and MYD88 mutation in colonic and bone marrow specimens.
Pengembangan Website Kimia Zat Warna Dalam Eco Fashion
Authors: Hika Hanum Hikmatul
Published: November 2021

Pencemaran zat pewarna dalam produksi batik merupakan isu lingkungan yang belum dipahami masyarakat. Penanggulangan yang dilakukan pemerintah adalah dengan menerapkan konsep eco fashion dalam batik dengan penggunaan pewarna alam. Kurangnya kesadaran tentang batik pewarna alami masih menjadi hambatan. Sehingga diperlukan media edukasi dan sosialisasi untuk meningkatkan pemahaman masyarakat. Media website merupakan media yang mudah diakses, selain itu website mampu memberikan informasi menjadi lebih efisien dan up to date. Oleh karena itu, penelitian ini bertujuan untuk mengambangan produk website kimia zat warna dalam eco fashion dan kelayakannya. Pengembangan website mengadaptasi model 4-D (Define, Design, Develop, Disseminate) yang dibatasai sampai tahap develop (pengembangan). Produk ditinjau oleh dosen pembimbing untuk mendapat saran dan masukan, kemudian kualitas produk dinilai oleh ahli materi, ahli media, dan 20 orang reviewer (masyarakat). Penilaian website dilakukan dengan instrumen penilaian kualitas Skala Likert. Hasil penilaian berupa data kuantitatif kemudian dianalisis untuk menentukan kualitas produk. Hasil uji kualitas menunjukkan bahwa pengembangan website kimia zat warna dalam eco fashion memperoleh persentase keidealan kualitas website berdasarkan penilaian ahli materi 95% dengan kategori Sangat Baik (SB), ahli media 95% dengan kategori Sangat Baik (SB), dan reviewer (masyarakat) dengan penilaian materi 84% dengan kategori Sangat Baik (SB) dan penilaian media 81.2% dengan kategori Sangat Baik (SB).
Pengembangan Media Pembelajaran Edmodo Berbasis Blended Learning Berorientasi Representasi Kimia
Authors: Waroh Zahrotul Ma
Published: November 2021

Penelitian ini bertujuan mengembangkan media pembelajaran edmodo berbasis blended learning berorientasi representasi kimia dan mengkaji kualitas produk, serta mengkaji respon peserta didik.  Penelitian dilakukan dengan menggunakan model pengembangan 4-D ‎yang terdiri atas 4 tahap, yaitu define, design, development, dan disseminate. ‎Penelitian ini dibatasi sampai tahap ketiga atau development. Produk dinilai menggunakan instrumen penilaian kualitas skala Likert dan Gutmann. Produk yang ‎dikembangkan dinilaikan kepada dosen ahli media, dosen ahli materi, dan guru kimia SMA/MA dan direspon oleh peserta didik. Hasil penelitian menunjukan bahwa berdasarkan penilaian dosen ahli materi, dosen ahli media, dan guru kimia SMA/MA, produk yang dikembangkan memiliki kualitas yang sangat baik dengan presentase keidealan berturut-turut sebesar 96,42%; 77,5%; dan 80,5%. Sedangkan untuk respon peserta didiknya dikategorikan sangat baik dengan presentase keidealan sebesar 90,6%.
Pengembangan Android Mobile Learning “Puzzle Of Chemistry” Berbasis Contextual Learning Pada Materi Asam Basa
Authors: Pamungkas Oky
Published: November 2021

Materi kimia SMA/MA lebih banyak diwarnai dengan materi konseptual teoretik keilmuan kimia dibandingkan dengan aplikasi ilmu kimia dalam kehidupan sehari-hari. Media pembelajaran kimia yang memuat contextual learning pada materi asam basa cocok untuk menjadi solusi dari hal tersebut, namun media pembelajaran yang dikembangkan tentunya harus memerhatikan ketertarikan siswa dan kemajuan perkembangan zaman saat ini sehingga perlu dikembangkan media yang interaktif dan mudah diakses oleh siswa. Oleh karena itu, penelitian bertujuan untuk mengembangkan media pembelajaran yang memuat contextual learning pada materi asam basa dalam bentuk game android interaktif. Penelitian ini dilakukan dengan metode 4-D. sebelum produk dinilai oleh lima guru kimia SMA/MA dan direspon oleh sepuluh siswa kelas XI MIA, produk yang dikembangkan divalidasi oleh dosen ahli media dan ahli materi. Produk yang dinilaikan dengan menggunakan skala likert dan guttman. Hasil penlitian yang diperoleh bahwa media game android puzzle of chemistry berbasis contextual learning pada materi asam basa memiliki karakteristik game yang memuat contextual learning. Berdasarkan penilaian validasi ahli materi dan ahli media bahwa produk yang dikembangkan termasuk ke dalam kategori baik, sedangkan respon guru kimia mendapatkkan persentase keidealan sebesar 96,3% termasuk kategor Sangat Baik (SB), dan respon siswa SMA/MA kelas XI MIA memperoleh persentase keidealan sebesar 87% termasuk kategori Sangat Baik (SB).
Analisis Persepsi Mahasiswa Tentang Pendidikan Inklusif
Authors: Nugraheni Nur Indah , Karmanto
Published: November 2021

Mahasiswa kependidikan merupakan mahasiswa yang dipersiapkan sebagai calon pendidik. Salah satunya adalah mahasiswa pendidikan kimia yang dipersiapkan sebagai calon guru kimia. Mahasiswa pendidikan kimia hendaknya memiliki pemahaman yang komprehensif terkait pendidikan inklusif karena fakta dilapangan memperlihatkan tidak ada siswa yang sempurna. Penelitian yang dilakukan bertujuan untuk mengidentifikasi persepsi mahasiswa pendidikan kimia UIN Sunan Kalijaga tentang pendidikan inklusif, menganalisis faktor-faktor yang mempengaruhi persepsi mahasiswa, dan merumuskan model matematis untuk persepsi mahasiswa tentang pendidikan inklusif. Kajian identifikasi persepsi mahasiswa tentang pendidikan inklusif dilakukan dengan metode survei, instrumen yang digunakan adalah kuisioner, serta teknik analisis data yang digunakan adalah analisis deskriptif. Analisis faktor yang mempengaruhi persepsi mahasiswa tentang pendidikan inklusif dilakukan dengan metode survei, instrumen yang digunakan adalah kuisioner, serta teknik analisis data dengan kategorisasi. Merumuskan model matematis untuk persepsi mahasiswa tentang pendidikan inklusif berdasarkan faktor yang mempengaruhi dilakukan dengan metode statistika regresi linier berganda. Hasil penelitian menunjukkan mahasiswa pendidikan kimia UIN Sunan Kalijaga memiliki persepsi sedang tentang pendidikan inklusif sebesar 39,09% dengan mean 111,26. Berdasarkan hasil penelitian, faktor internal yang berpengaruh terhadap persepsi mahasiswa adalah aspek pengetahuan. Sedangkan faktor eksternal yang berpengaruh terhadap persepsi mahasiswa adalah aspek kerjasama. Berdasarkan analisis yang dilakukan, model matematis yang sesuai dengan faktor-faktor yang mempengaruhi persepsi mahasiswa tentang pendidikan inklusif dirumuskan sebagai Y = 8,202 + 3,696X1 + 4,201X2.
Identifikasi Potensi Budaya Lokal Berbasis Etnokimia Di kabupaten Bantul
Authors: Azizah Nur , Premono Shidiq
Published: November 2021

Kebudayaan dapat dimanfaatkan sebagai sumber pembelajaran, misalnya etnokimia sehingga keberadaannya tetap terjaga. Etnokimia merupakan pembelajaran kimia yang dikaitkan dengan budaya. Penelitian ini bertujuan untuk mengkaji potensi budaya lokal Kabupaten Bantul bidang industri kerajinan berbasis etnokimia dan mengkaji keterkaitan antara potensi budaya lokal Kabupaten Bantul bidang industri kerajinan dengan pembelajaran kimia. Penelitian yang dilakukan adalah penelitian deskriptif kualitatif. Teknik pengumpulan data pada penelitian ini adalah observasi, wawancara, dan studi pustaka.  Keabsahan data   yang   digunakan   adalah   uji   kredibilitas   dengan triangulasi data, uji dependabilitas, dan uji konfirmabilitas. Adapun teknik analisa data menggunakan metode Miles Huberman berupa reduksi data, penyajian data, dan penarikan kesimpulan. Data yang terkumpul dikategorisasikan dan disusun secara sistematis kemudian dibuat kesimpulan. Hasil penelitian menunjukkan bahwa potensi budaya lokal Kabupaten dapat dijadikan sebagai sumber pembelajaran berbasis kimia. Potensi budaya lokal berbasis etnokimia di Kabupaten Bantul adalah kerajinan batik, keris, gamelan, dan wayang kulit. Batik dapat dikaitkan dengan materi larutan asam basa, ikatan kimia, konsep mol, dan tata nama kimia. Keris dapat dikaitkan dengan materi sel volta dan korosi serta kimia unsur (periode 4). Gamelan dapat dikaitkan dengan materi reaksi oksidasi dan reduksi serta kimia unsur (periode 4). Wayang kulit dapat dikaitkan dengan materi polimer dan koloid.
Pengembangan Buku Petunjuk Praktikum Kimia Dengan Bahan Alam Untuk Siswa SMA/MA Kelas X
Authors: Safitri Amalia Delma
Published: November 2021

Pembelajaran kurikulum 2013 menekankan pada pendekatan saintifik dengan pembelajaran yang mendorong peserta didik agar lebih mampu dalam mengamati, menanya, mencoba atau mengumpulkan data, mengasosiasi atau menalar, dan mengomunikasikan. Salah satu cara pencapaian kompetensinya yaitu melalui kegiatan praktikum. Tetapi kegiatan praktikum belum sepenuhnya dapat dilaksanakan di sekolah, karena laboratorium yang kurang memadai, tidak terdapat laboran, beberapa alat yang kurang memenuhi secara standar mutu dan jumlah yang terbatas, jam pelajaran yang cukup padat, lebih menekankan pada materi, dan harga bahan-bahan kimia yang terbilang cukup mahal. Hal ini menjadi dasar untuk dirancangnya buku petunjuk praktikum kimia dengan bahan alam untuk SMA/MA kelas X, dengan bahan alam seperti buah dan sayur, sehingga peserta didik bisa melaksanakan praktikum dengan mengganti bahan kimia yang berbahaya dengan bahan alam. Penelitian dikembangankan dengan metode 4-D dengan 4 tahapan yaitu pendefinisian (define), perencanaan (design), pengembangan (develop), dan penyebarluasan (disseminate). Produk yang ‎dikembangkan ditinjau oleh dosen pembimbing dan peer reviewer untuk ‎diberikan saran perbaikan, kemudian dinilaikan kepada dosen ahli media dan ‎dosen ahli materi sekaligus memberikan saran perbaikan, untuk kemudian dinilaikan ‎oleh guru kimia SMA/MA, dan diresponpesrta didik kelas X. Hasil penelitian menunjukan bahwa berdasarkan penilaian ahli materi, buku petunjuk praktikum yang ‎dikembangkan mendapatkan persentase keidealan 89,59% sehingga ‎dikategorikan Sangat Baik (SB). Penilaian oleh ahli media mendapatkan persentase keidealan 69,4% sehingga dikategorikan Baik (B). Hasil penilaian dari guru kimia mendapatkan persentase ‎keidealan 94,6% sehingga masuk kategori Sangat Baik (SB), dan berdasarkan respon ‎peserta didik kelas X persentase keidealan 92% ‎sehingga masuk kategori Sangat Baik (SB).
O ensino e a aprendizagem da matemática: entre o gramatical e o empírico
Authors: Pinheiro Teixeira Junior Valdomiro , Abreu da Silveira Marisa Rosâni , Vilhena da Silva Paulo
Published: November 2021

Este texto tem o objetivo de analisar possibilidades inerentes ao ensino e aprendizagem da matemática, onde buscamos refletir, a partir da filosofia da linguagem de Wittgenstein, sobre como poderíamos pensar o ensino: gramatical ou empírico? Baseado em regras ou na experiência? Realizamos um ensaio teórico, no qual discutimos inicialmente o papel gramatical da linguagem e da matemática, onde tratamos das proposições matemáticas como proposições gramaticais, e seus usos empíricos e, então, refletimos sobre possibilidades pedagógicas vislumbrando os contextos gramatical e empírico. Concluímos, a partir da análise realizada que o aluno precisa compreender regras da matemática (gramatical), mas seu ensino pode se valer de atividades de aplicação na realidade (empírico), que devem ser vistas a partir da noção de jogos de linguagem.
Apuntes sobre la investigación en la universidad
Authors: Suzunaga Quintana Juan Carlos
Published: November 2021

¿Qué es investigación? Es una pregunta que está desapareciendo de la acade- mia, en virtud de que se parte cada vez de la obviedad. No obstante, aun resue- na esta pregunta, ya no en las aulas, sino, en los corredores de la universidad, y vuelve a cobrar su verdor en los debates que se llevan a cabo en el campus universitario.

En estos apuntes quisiera ponerla nuevamente a circular. Hacer de una editorial, par- te del campus, un lugar de la universidad más allá de las aulas, pero vinculado a estas.
Education in times of global crisis: How private actors in Germany gain power through Twitter
Authors: Schuster Johannes , Kolleck Nina
Published: November 2021

The outbreak of the COVID-19 pandemic led to enormous societal changes worldwide and touched many different areas of daily life. One of the most serious restrictions to contain the pandemic was the closure of schools and kindergartens. Particularly in countries with comparatively low levels of digitalization in schools, this situation opened up opportunities for private actors to gain importance and influence in the education sector. For this article, we draw on policy network approaches and network theory to analyze Twitter discussions around digital learning and homeschooling during the period of school closures in Germany due to the COVID-19 crisis. We use social network analysis to identify the actors involved and their influences in the issue-specific Twitter communication network. In recent years, Twitter has been increasingly used for exchanges on education policy content, mainly by political and civil society actors. Our study shows that with respect to digital learning and homeschooling, it was primarily individual experts and consultants as well as corporations which influenced the discourse. In particular, it appears that Twitter is used as a forum to promote corporations’ own products and platforms, including by globally operating corporations such as Microsoft and YouTube, while public actors remain barely visible.
Adam Tooze: Crashed: How a Decade of Financial Crises Changed the World; Adam Tooze: Shutdown: How Covid Shook the World’s Economy
Authors: Árnason Jóhann Páll
Published: November 2021

Book reviews: Adam Tooze: Crashed: How a Decade of Financial Crises Changed the World. London: Allen Lane, 2018, 218 pp.
Adam Tooze: Shutdown: How Covid Shook the World’s Economy. London: Allen Lane, 2021, 368 pp.
Wielkie problemy mikrojęzyka
Authors: Walczak-Mikołajczakowa Mariola
Published: November 2021

Artykuł zwiera recenzję książki Marineli Mladenovej Банатски български книжовен език в контекста на славянската микролингвистика. История, динамика на нормата и езикови политики, której autorka skupia się na normalizacji i rozwoju norm języka bułgarskiej mniejszości zamieszkującej Banat. Literacki język Bułgarów z Banatu ma status języka wyspowego, gdyż posługuje się nim katolicka społeczność od ponad dwustu lat żyjąca poza ojczyzną, w obcym otoczeniu językowym. Z czasem – w dużej mierze pod wpływem języka chorwackiego, rumuńskiego i węgierskiego – rozwinął własną normę literacką i uznawany jest dziś za mikrojęzyk. Książka Marineli Mladenowej, a w ślad za nią także niniejszy artykuł dotyczą czynników politycznych i społecznych, które oddziaływały na rozwój tej normy.
Афективното естество на реализма – за не-човешките субекти в прозата на Вилхелм Мах
Authors: Ковачева Адриана
Published: November 2021

Статията разглежда мястото на творчеството на Вилхелм Мах през 60-те години на ХХ век в полската проза, когато се смята, че романът има основно познавателни цели. Мах не се противопоставя пряко на тази тенденция, но основният проблем, който го интересува, е какво превръща литературата в преживяване. Статията проследява развитието на този въпрос в творчеството на писателя, съсредоточавайки се върху епизоди и фрагменти от неговата проза, в които са описани мъчения и убийства на домашни животни. Тези сцени показват основните механизми за предаване на афекти в прозата на Мах. Техният анализ показва, че според писателя литературата работи тогава, когато е в състояние да предаде афекта и да създаде условия за неговото пълно изразяване. Поставена е хипотезата, че афективният реализъм, който търси Мах, може да бъде четен като контекст и контрапункт за прозата на Блага Димитрова.
Epsilon-Efficiency in a Dynamic Partnership with Adverse Selection and Moral Hazard
Authors: Cao Vi
Published: November 2021

For a dynamic partnership with adverse selection and moral hazard, we design a direct profit division mechanism that satisfies ϵ-efficiency, periodic Bayesian incentive compatibility, interim individual rationality, and ex-post budget balance. In addition, we design a voting mechanism that implements the profit division rule associated with this direct mechanism in perfect Bayesian equilibrium. For establishing these possibility results, we assume that the partnership exhibits intertemporal complementarities instead of contemporaneous complementarities; equivalently, an agent’s current effort affects other agents’ future optimal efforts instead of current optimal efforts. This modelling assumption fits a wide range of economic settings.
Effectiveness of line type and cross type piezoelectric patches on active vibration control of a flexible rectangular plate
Authors: Atul  , Deepak G. Divya
Published: November 2021

In the present work, vibration control of a simply supported plate with line type and cross type piezoelectric (PZT) patches are investigated with and without actuation voltage. The plate is modeled under the assumption of Kirchhoff’s Plate theory. The mass of PZT patches remain constant in all cases. In case of actuation, applied voltage considered are 1, 2 and 3 mV. The external excitation to the plate is in the form of harmonically varying point load of 1 mN. It is noticed that cross type PZT patch is more effective in deflection suppression of plate than that of line type PZT patch at 3 mV of actuation at patch thickness of 0.75 μm. Suppression of central deflection of plate for line type and cross type PZT patches are obtained in different frequency bands of (175–185 Hz) and (870–880 Hz) respectively.
Modelling and numerical synchronization of chaotic system with fractional-order operator
Authors: Owolabi Kolade M.
Published: November 2021

Numerical solution of nonlinear chaotic fractional in space reaction–diffusion system is considered in this paper on a large but finite spatial domain size x ∈ [0, L] for L ≫ 0, x = x(x, y) and t ∈ [0, T]. The classical order chaotic ordinary differential equation is formulated by introducing the second-order spatial fractional derivative with order β ∈ (1, 2]. This second order spatial derivative is modelled by using the definition of the Riesz fractional derivative. The method of approximation combines the Fourier spectral method with the novel exponential time difference schemes. The proposed technique is known to have gained spectral accuracy over finite difference schemes. Applicability and suitability of the suggested methods are tested on Rössler chaotic system of recurring interests in one and two dimensions.
Weighted pseudo asymptotically Bloch periodic solutions to nonlocal Cauchy problems of integrodifferential equations in Banach spaces
Authors: Chang Yong-Kui , Zhao Jianguo
Published: November 2021

This paper is mainly concerned with some new asymptotic properties on mild solutions to a nonlocal Cauchy problem of integrodifferential equation in Banach spaces. Under some well-imposed conditions on the nonlocal Cauchy, the neutral and forced terms, respectively, we establish some existence results for weighted pseudoS-asymptotically (ω,k)-Bloch periodic mild solutions to the referenced equation onR+${\mathbb{R}}_{+}$by suitable superposition theorems. The results show that the strict contraction of the nonlocal Cauchy and the neutral terms with the state variable has an appreciable effect on the existence and uniqueness of such a solution compared with the forced term. As an auxiliary result, the existence of weighted pseudoS-asymptotically (ω,k)-Bloch periodic mild solutions is deduced under the sublinear growth condition on the force term with its state variable. The existence of weighted pseudoS-asymptoticallyω-antiperiodic mild solution is also obtained as a special example.
Deutsch für das Studium digital vermitteln – Didaktische Konzeption und studentische Perspektiven
Authors: Ide Robin , Rahn Stefan , Röder Sophia , Rüger Antje , Zacharias Teres
Published: November 2021

Der Artikel stellt ein digitales Lehrangebot zur akademischen Sprachverwendung von Deutsch für internationale Studierende vor. Ausgehend von einigen didaktisch-konzeptionellen Überlegungen werden die Online-Materialien und Lernaktivitäten überblicksartig beschrieben und anhand einer Unterrichtssequenz zum mündlichen Präsentieren exemplarisch beleuchtet. Anschließend werden die Ergebnisse einer qualitativen Interviewstudie mit sieben ehemaligen Studierenden vorgestellt, in der das digitale Lehrangebot evaluiert wurde.
The Underlying Values of Data Ethics Frameworks: A Critical Analysis of Discourses and Power Structures
Authors: Häußler Helena
Published: November 2021

A multitude of ethical guidelines and codes of conduct have been released by private and public organizations during the past years. Those abstract statements serve as a response to incidents of discriminatory algorithms and systems and have been quantitatively investigated for the proclaimed principles. The current study focuses on four frameworks designed for application during the development of new technologies. The purpose is to identify values and value conflicts and consider how these are represented in relation to established discourses, practices, and attitudes in Computer and Information Ethics. This helps to understand to what extent the frameworks contribute to social change. Critical Discourse Analysis according to Fairclough is used to examine language and discourses, and review edition and publication processes. Well-established values like transparency, non-maleficence, justice, accountability, and privacy were detected whereas value conflicts were barely addressed. Interestingly, the values were more often framed by a business, and technology discourse than an ethical discourse. The results suggest a hegemonic struggle between academia and tech industry whereas power asymmetries between developers and stakeholders are reinforced. It is recommended to extend stakeholder participation from the beginning and emphasize value conflicts. This can contribute to advance the field and effectively encourage a public debate about the desired technological progress.
AMBRA1 attenuates the proliferation of uveal melanoma cells
Authors: Zhao Binbin , Yang Yun , Cun Biyun , Chen Ping
Published: November 2021

Uveal melanoma (UVM) is the most common primary intraocular malignancy in adults with high metastasis rates. D-type cyclins (CCNDs) are central regulators of the cell division cycle and are among the most frequently deregulated therapeutic targets in human cancer. Recently, the E3 ligase adaptor, autophagy and beclin 1 regulator 1 (AMBRA1), was reported to regulate the stability of CCNDs, including CCND1, but its role in UVM has not been demonstrated. AMBRA1 is lowly expressed in UVM cells, and the ablation of AMBRA1 promotes the proliferation of 92.1 and OMM1 cells, whereas ectopically expressing AMBRA1 attenuates the proliferation of UVM cells. Further studies found that AMBRA1 promotes the ubiquitination and degradation of CCND1, and AMBRA1 regulates the proliferation of UVM cells in a CCND1-dependent manner. Thus, this study suggests that AMBRA1 serves as an important tumor suppressor by limiting UVM cell growth.
Multilingual education in an Italian public preschool: teachers and families among mobility processes and inclusive practices
Authors: Carbonara Valentina
Published: November 2021

This paper focuses on the integration of translanguaging practices in a public preschool situated in a small village in North-West of Italy. Mobility processes and local Italian families’ school choices have led to the raise of the number of students with an immigrant background enrolled at the studied preschool up to 85%. After a brief overview regarding mobility and translanguaging in education, particularly in relation to preschool domain, I describe the macro and micro contexts of this ethnographic case study. I then focus on the analysis of the main learning activities designed by teachers to engage children’s multilingual repertoires. Later, applying qualitative content analysis, I outline the main patterns and categories emerging from interviews and focus groups conducted with teachers and parents to investigate how they experienced the marginalization of immigrant minority children in their preschool and how they received the introduction of multilingual education approach. The results shows that the adoption of a translanguaging lens contributed to the educational legitimation of language diversity and to the acknowledgment of immigrant families. Finally, I discuss the results in terms of democratic language education and social justice, underlining their implications and relevance for preschools teachers’ professional development and agency.
Das Dilemma desGnaeus Flavius.Diskurse über Rechtswissenschaft und Soziologie um 1910.
Authors: Lautmann Rüdiger
Published: November 2021

Der Artikel behandelt in drei Teilen die Diskurse, die Anfang des 20. Jahrhunderts zur disziplinären Abgrenzung zwischen Rechtswissenschaft und Soziologie geführt worden sind, fokussiert auf den Stimmführer Hermann Kantorowicz. Im ersten Teil wird untersucht, wie der Diskurs um das richtige Recht die Abgrenzung der Jurisprudenz gegenüber der Soziologie hervorbrachte. Der zweite Teil widmet sich der programmatischen Figur einer soziologischen Jurisprudenz, also dem historischen Moment einer wechselseitigen Durchdringung von Rechtswissenschaft und Soziologie – mit dem Resultat, dass die Interpenetration nicht stattgefunden hat. Der dritte Teil schildert die Frühphase der Soziologie – die Konstitution des neuen Fachs gelang per Abwendung von der Rechtswissenschaft. Die anfängliche Nähe zwischen Rechts- und Sozialwissenschaft löste sich auf. Webers Postulat der Wertfreiheit stand der von der Freirechtslehre gewünschten Kooperation im Wege. Die hier aufgeworfenen Fragen sind bis heute offen.