bluuebunny/crossref_metadata_2025 huggingface dataset:
Mekân ve İki Kadın: Esnekleşme ve ‘Güvencenin Taşeronlaşması’ Üzerine Bir Anlatı | Space And Two Women: A Narrative on Flexibility and ‘Subcontracting of Assurance’
Authors: YİĞİT Emin
Published: November 2022

Esnekleşme ve güvencesizleşeme kavramlarını literatürün en başat tartışma alanlarından birisi haline getiren neoliberalizm, piyasa aklını da toplumsallaştırma potansiyelini barındırmaktadır. Üretim ilişkilerinin, toplumsal yapının bir parçası olarak ideolojinin de üretimine katkı yaptığı gerçekliğini hem akıldan çıkarmamak hem de bu noktada cinsiyet körü olmamak gerekir. Erilmerkezciliğin kapitalizmle iş birliğinin mekânda tezahürü kadın emeği üzerinde doğrudan belirleyici olmaktadır. Bu nedenle mekânın sosyal yönü yani mekânın da üretimci doğası dışarıda bırakılmamalıdır. Erilmerkezciliğin kurumsallaşması vasıtasıyla kendini sürekli üreten patriarka, çalışma mekânı ve çalışmanın kendisi üzerinde de belirleyici olarak kadınların emek güçlerini denetim altına almakta ve disipline etmektedir. Patriarkal sistemin temelini oluşturan bu yapı gündelik yaşam içerisinde de kendini sürekli üretirken “güvence taşeronlaşmaktadır”. Makale için, 2010 yılında tamamlanan ve yirmi sekiz katılımcı ile yapılan doktora tezinin verileri yol gösterici olsa da bu çalışmada, doktora tezinin katılımcısı da olan ve aynı mekânda çalışan iki kadının anlatılarına dayanılmıştır. Sonraki yıllarda da verilerin izi sürülmüştür. Dolayısıyla çalışmada amaçlanan, erilmerkezciliğin çalışma, mekân ve toplum içinde nasıl tezahür ettiğinin ve gündelik yaşama nasıl yansıdığının “güvence” kavramı üzerinden tartışılmasıdır.
DEVELOPMENT OF MEDIA DOMINO CARD ON MATERIAL TEMPERATURE AND CHANGES IN CLASS VII SMP/ MTs
Authors: Fitri Nikmaturrofidah  , Oktaffi Arinna Manasikana
Published: November 2022

This study aims to describe the process of developing domino science learning media on the material of temperature and its changes in class VII SMP/MTs based on the ADDIE development procedure and to describe the product developed after the validation, practicality and effectiveness process. This development research uses the ADDIE development model, namely, Analyze, Design, Development, Implementation, and Evaluation. Data were obtained using media validation sheets, material validation sheets, implementation sheets for using domino card science learning media, student response questionnaire sheets and posttest question sheets. The results of the research on the development of domino card science learning media on the temperature material and its changes that have been developed resulted in 3 drafts of domino card science learning media that have received suggestions and input from supervisors and validators, namely media experts, materials and science teachers. The results of the validator's assessment of the domino card science learning media obtained an average score of 3.82 from media expert validators, and 3.25 from material expert validators in the "Very Valid" category. The results of the implementation showed the percentage of implementation was 94.45% with the "Very Practical" category. The results of student responses obtained an average positive response of 96.88% with the category "Very Practical". Based on the posttest data, the overall average score is 84.37 and the average completeness is 75% with the "Effective" category. 25 of the material expert validators in the "Very Valid" category. The results of the implementation showed the percentage of implementation was 94.45% with the "Very Practical" category. The results of student responses obtained an average positive response of 96.88% with the category "Very Practical". Based on the posttest data, the overall average score is 84.37 and the average completeness is 75% with the "Effective" category. 25 of the material expert validators in the "Very Valid" category. The results of the implementation showed the percentage of implementation was 94.45% with the "Very Practical" category. The results of student responses obtained an average positive response of 96.88% with the category "Very Practical". Based on the posttest data, the overall average score is 84.37 and the average completeness is 75% with the "Effective" category.
Immobilized nanoscale zero-valent iron for synergistic enhanced removal of pentachlorobenzene with Pseudomonas sp. JS100
Authors: Ma Anzhou , Ma Jianpeng , Chen Xianke , Zhuang Guoqiang
Published: November 2022

Highly chlorinated benzenes usually have a low efficient degradation in environment. Here we proposed a synergistic removal strategy of pentachlorobenzene (PeCB) using Pseudomonas sp. JS100 coupled with immobilized nanoscale zero-valent iron (NZVI). The structural and textural features of the synergistic system were characterized by X-ray powder diffraction, field emission scanning electron microscopy, and a specific surface area and pore size analysis. Nanoscale zero-valent iron particles were dispersed and attached to the biofilter, which increased the specific surface area to 34.5 m2 g−1. The batch experiment revealed that the removal efficiency of PeCB reached 80.2% in the synergistic system within 48 h. The degradation followed pseudo-first-order reaction kinetics, and the reaction rate constant was measured to be 0.0336 h−1. In the degradation mechanism, PeCB was degraded by NZVI to lower chlorobenzenes, which were utilized by Pseudomonas sp. JS100 as nutrients, thereby achieving rapid removal of PeCB.
Motivations for birdwatching scale – Developing and testing an integrated measure on birding motivations
Authors: Randler Christoph , Großmann Nadine
Published: November 2022

Introduction

Birding has become a widespread, nature-related outdoor leisure activity. However, birding motivation has received little attention in research on this leisure activity so far. Since previous work showed some inconsistencies that are based on different measurements and concepts, the current study aimed at unifying and broadening the construct of birding motivation. For this purpose, we summarized the previous attempts to assess and categorize birding motivation and tried to unify them in one measurement model.

Methods

Starting point was a widely accepted model on outdoor recreation to which further dimensions have been added. We investigated birders (N=569) from German speaking countries regarding their birding motivations, birding specialization, and participation in various bird-related projects.

Results

Exploratory factor analysis revealed six motivation factors: Enjoyment had the highest scale mean, followed by achievement, conservation, detachment, social, and finally reputation. Confirmatory factor analysis showed a better fit of the posited six-factor model compared to the previous three-factor model supporting the initial concept of adding further scales to cover the motivational constructs more widely. Higher skilled, specialized and involved birders showed higher motivation in the dimensions conservation, social, and reputation. Conservation motivation was highly correlated with submitting observations to a citizen sciences portal and with participating in breeding bird surveys or waterbird counts.

Discussion

With our results, we expand the basic three-dimensional model of recreation motivation with the additional dimensions conservation, detachment, and reputation.
The guanine nucleotide exchange factor Vav3 intervenes in the migration pathway of oligodendrocyte precursor cells on tenascin-C
Authors: Schäfer Ina , Bauch Juliane , Wegrzyn David , Roll Lars , van Leeuwen Simon , Jarocki Annika , Faissner Andreas
Published: November 2022

Oligodendrocyte precursor cells (OPCs) are the exclusive source of myelination in the central nervous system (CNS). Prior to myelination, OPCs migrate to target areas and mature into myelinating oligodendrocytes. This process is underpinned by drastic changes of the cytoskeleton and partially driven by pathways involving small GTPases of the Rho subfamily. In general, the myelination process requires migration, proliferation and differentiation of OPCs. Presently, these processes are only partially understood. In this study, we analyzed the impact of the guanine nucleotide exchange factor (GEF) Vav3 on the migration behavior of OPCs. Vav3 is known to regulate RhoA, Rac1 and RhoG activity and is therefore a promising candidate with regard to a regulatory role concerning the rearrangement of the cytoskeleton. Our study focused on the Vav3 knockout mouse and revealed an enhanced migration capacity of Vav3−/− OPCs on the extracellular matrix (ECM) glycoprotein tenascin-C (TnC). The migration behavior of individual OPCs on further ECM molecules such as laminin-1 (Ln1), laminin-2 (Ln2) and tenascin-R (TnR) was not affected by the elimination of Vav3. The migration process was further investigated with regard to intracellular signal transmission by pharmacological blockade of downstream pathways of specific Rho GTPases. Our data suggest that activation of RhoA GTPase signaling compromises migration, as inhibition of RhoA-signaling promoted migration behavior. This study provides novel insights into the control of OPC migration, which could be useful for further understanding of the complex differentiation and myelination process.
IgG anti-RBD levels during 8-month follow-up post-vaccination with BNT162b2 and mRNA-1273 vaccines in healthcare workers: A one-center study
Authors: Gil-Manso Sergio , Alonso Roberto , Catalán Pilar , Sánchez-Arcilla Ignacio , Marzola Marco , Correa-Rocha Rafael , Pion Marjorie , Muñoz Patricia ,   Gregorio Marañón Microbiology-ID COVID-19 Study Group
Published: November 2022

Introduction

Since the COVID-19 outbreak, specific mRNA-based anti-SARS-CoV-2 vaccines have been developed and distributed worldwide. Because this is the first time that mRNA vaccines have been used, there are several questions regarding their capacity to confer immunity and the durability of the specific anti-SARS-CoV-2 response. Therefore, the objective of this study was to recruit a large cohort of healthcare workers from the Gregorio Marañón Hospital vaccinated with the mRNA-1273 or BNT126b2 vaccines and to follow-up on IgG anti-RBD levels at 8 months post-vaccination.

Methods

We recruited 4,970 volunteers and measured IgG anti-RBD antibodies on days 30 and 240 post-vaccination.

Results

We observed that both vaccines induced high levels of antibodies on day 30, while a drastic wane was observed on day 240, where mRNA-1273 vaccinated induced higher levels than BNT162b2. Stratifying by vaccine type, age, gender, and comorbidities, we identified that older mRNA-1273-vaccinated volunteers had higher antibody levels than the younger volunteers, contrary to what was observed in the BNT162b2-vaccinated volunteers.

Discussion

In conclusion, we observed that mRNA-1273 has a higher capacity to induce a humoral response than BNT162b2 and that age is a factor in the specific response.
Human blood vessel microbiota in healthy adults based on common femoral arteries of brain-dead multi-organ donors
Authors: Hidi László , Kovács Gergely Imre , Szabó Dóra , Makra Nóra , Pénzes Kinga , Juhász János , Sótonyi Péter , Ostorházi Eszter
Published: November 2022

Discovery of human microbiota is fundamentally changing our perceptions of certain diseases and their treatments. However little is known about the human blood vessel microbiota, it may have important effects on vascular pathological lesions and vascular homograft failure. In our prospective survey study fourteen femoral arteries, harvested from donors in multi-organ donations, were examined using the V3-V4 region 16S rRNA sequencing method. The most abundant phyla in the human vascular microbiota were Proteobacteria, Firmicutes and Actinobacteria. At the genus level, the most abundant taxa were Staphylococcus, Corynebacterium, Pseudomonas, Bacillus, Acinetobacter and Propionibacterium. Of the bacterial taxa that have an indirect effect on the development of atherosclerosis, we found Porphyromonas gingivalis, Prevotella nigrescens and Enterobacteriaceae spp. with different abundances in our samples. Of the bacteria that are more common in the intestinal flora of healthy than of atherosclerosis patients, Roseburia and Ruminococcus occurred in the majority of samples. The human arterial wall has a unique microbiota that is significantly different in composition from that of other areas of the body. Our present study provides a basis for ensuing research that investigates the direct role of the microbiota in vascular wall abnormalities and the success of vascular allograft transplantations.
Targeting malaria parasites with novel derivatives of azithromycin
Authors: Burns Amy L. , Sleebs Brad E. , Gancheva Maria , McLean Kimberley T. , Siddiqui Ghizal , Venter Henrietta , Beeson James G. , O’Handley Ryan , Creek Darren J. , Ma Shutao , Frölich Sonja , Goodman Christopher D. , McFadden Geoffrey I. , Wilson Danny W.
Published: November 2022

Introduction

The spread of artemisinin resistant Plasmodium falciparum parasites is of global concern and highlights the need to identify new antimalarials for future treatments. Azithromycin, a macrolide antibiotic used clinically against malaria, kills parasites via two mechanisms: ‘delayed death’ by inhibiting the bacterium-like ribosomes of the apicoplast, and ‘quick-killing’ that kills rapidly across the entire blood stage development.

Methods

Here, 22 azithromycin analogues were explored for delayed death and quick-killing activities against P. falciparum (the most virulent human malaria) and P. knowlesi (a monkey parasite that frequently infects humans).

Results

Seventeen analogues showed improved quick-killing against both Plasmodium species, with up to 38 to 20-fold higher potency over azithromycin after less than 48 or 28 hours of treatment for P. falciparum and P. knowlesi, respectively. Quick-killing analogues maintained activity throughout the blood stage lifecycle, including ring stages of P. falciparum parasites (<12 hrs treatment) and were >5-fold more selective against P. falciparum than human cells. Isopentenyl pyrophosphate supplemented parasites that lacked an apicoplast were equally sensitive to quick-killing analogues, confirming that the quick killing activity of these drugs was not directed at the apicoplast. Further, activity against the related apicoplast containing parasite Toxoplasma gondii and the gram-positive bacterium Streptococcus pneumoniae did not show improvement over azithromycin, highlighting the specific improvement in antimalarial quick-killing activity. Metabolomic profiling of parasites subjected to the most potent compound showed a build-up of non-haemoglobin derived peptides that was similar to chloroquine, while also exhibiting accumulation of haemoglobin-derived peptides that was absent for chloroquine treatment.

Discussion

The azithromycin analogues characterised in this study expand the structural diversity over previously reported quick-killing compounds and provide new starting points to develop azithromycin analogues with quick-killing antimalarial activity.
Comparing heart rate variability biofeedback and simple paced breathing to inform the design of guided breathing technologies
Authors: Tabor Aaron , Bateman Scott , Scheme Erik J. , schraefel m.c.
Published: November 2022

Introduction

A goal of inbodied interaction is to explore how tools can be designed to provide external interactions that support our internal processes. One process that often suffers from our external interactions with modern computing technology is our breathing. Because of the ergonomics and low-grade-but-frequent stress associated with computer work, many people adopt a short, shallow breathing pattern that is known to have a negative effect on other parts of our physiology. Breathing guides are tools that help people match their breathing patterns to an external (most often visual) cue to practice healthy breathing exercises.However, there are two leading protocols for how breathing cues are offered by breathing guides used in non-clinical settings: simple paced breathing (SPB) and Heart Rate Variability Biofeedback (HRV-b). Although these protocols have separately been demonstrated to be effective, they differ substantially in their complexity and design. Paced breathing is a simpler protocol where a user is asked to match their breathing pattern with a cue paced at a predetermined rate and is simple enough to be completed as a secondary task during other activities. HRV-b, on the other hand, provides adaptive, real-time guidance derived from heart rate variability, a physiological signal that can be sensed through a wearable device. Although the benefits of these two protocols have been well established in clinical contexts, designers of guided breathing technology have little information about whether one is better than the other for non-clinical use.

Methods

To address this important gap in knowledge, we conducted the first comparative study of these two leading protocols in the context of end-user applications. In our N=28 between-subject design, participants were trained in either SPB or HRV-b and then completed a 10-minute session following their training protocol. Breathing rates and heart rate variability scores were recorded and compared between groups.

Results and discussion

Our findings indicate that the exercises did not significantly differ in their immediate outcomes – both resulted in significantly slower breathing rates than their baseline and both provided similar relative increases in HRV. Therefore, there were no observed differences in the acute physiological effects when using either SPB or HRV-b. Our paper contributes new findings suggesting that simple paced breathing – a straightforward, intuitive, and easy-to-design breathing exercise – provides the same immediate benefits as HRV-b, but without its added design complexities.
High sensitivity troponins: A potential biomarkers of cardiovascular risk for primary prevention
Authors: Leite Luis , Matos Pedro , Leon-Justel Antonio , Espírito-Santo Claudio , Rodríguez-Padial Luis , Rodrigues Fernando , Orozco Domingo , Redon Josep
Published: November 2022

There have been several approaches to building charts for CV risk, all of which have both strengths and limitations. Identifying early organ damage provides relevant information and should be included in risk charts, although the direct relationship with risk is imprecise, variability between operators at the time to assess, and low availability in some healthcare systems, limits its use. Biomarkers, like troponin (cTns) isoforms cTnI and cTnT, a cardiac specific myocyte injury marker, have the great advantage of being relatively reproducible, more readily accessible, and applicable to different populations. New and improved troponin assays have good analytical performance, can measure very low levels of circulating troponin, and have low intra individual variation, below 10 %. Several studies have analyzed the blood levels in healthy subjects and their predictive value for cardiovascular events in observational, prospective and post-hoc studies. All of them offered relevant information and shown that high sensitivity hs-cTnI has a place as an additional clinical marker to add to current charts, and it also reflects sex- and age-dependent differences. Although few more questions need to be answered before recommend cTnI for assessing CV risk in primary prevention, seems to be a potential strong marker to complement CV risk charts.
Novel hub genes associated with pulmonary artery remodeling in pulmonary hypertension
Authors: Tan Rubin , You Qiang , Yu Dongdong , Xiao Chushu , Adu-Amankwaah Joseph , Cui Jie , Zhang Ting
Published: November 2022

Pulmonary hypertension (PH) is a life-threatening disease with complex pathogenesis. According to etiology, PH is divided into five major groups in clinical classification. However, pulmonary artery (PA) remodeling is their common feature, in addition to bone morphogenetic protein receptor type 2; it is elusive whether there are other novel common genes and similar underlying mechanisms. To identify novel common hub genes involved in PA remodeling at different PH groups, we analyzed mRNA-Seq data located in the general gene expression profile GSE130391 utilizing bioinformatics technology. This database contains PA samples from different PH groups of hospitalized patients with chronic thromboembolic pulmonary hypertension (CTEPH), idiopathic pulmonary artery hypertension (IPAH), and PA samples from organ donors without known pulmonary vascular diseases as control. We screened 22 hub genes that affect PA remodeling, most of which have not been reported in PH. We verified the top 10 common hub genes in hypoxia with Sugen-induced PAH rat models by qRT-PCR. The three upregulated candidate genes are WASF1, ARHGEF1 and RB1 and the seven downregulated candidate genes are IL1R1, RHOB, DAPK1, TNFAIP6, PKN1, PLOD2, and MYOF. WASF1, ARHGEF1, and RB1 were upregulated significantly in hypoxia with Sugen-induced PAH, while IL1R1, DAPK1, and TNFA1P6 were upregulated significantly in hypoxia with Sugen-induced PAH. The DEGs detected by mRNA-Seq in hospitalized patients with PH are different from those in animal models. This study will provide some novel target genes to further study PH mechanisms and treatment.
An earthquake-triggered submarine mass failure mechanism for the 1994 Mindoro tsunami in the Philippines: Constraints from numerical modeling and submarine geomorphology
Authors: Ramirez Alec Benjamin G. , Ramos Noelynna T. , Nawanao Lyndon P. , Mangahas-Flores Robelyn Z. , Narag Ishmael C. , Baba Toshitaka , Chikasada Naotaka , Satake Kenji
Published: November 2022

Tsunamis have been known to result from a wide range of phenomena, such as earthquakes, volcanic eruptions, submarine mass failures, and meteorite impacts. Of earthquake-generated tsunamis, those arising from strike-slip mechanisms are less common, with the 1994 Mindoro tsunami in the Philippines among the few known examples. The 1994 Mindoro tsunami followed a Mw 7.1 earthquake along the right-lateral Aglubang River Fault. The tsunami affected the coasts surrounding the Verde Island Passage, one of the Philippines’ insular seas located between the islands of Luzon and Mindoro, and east of the West Philippine Sea margin. A total of 78 lives were lost due to the earthquake and tsunami, with 41 being directly attributed to the tsunami alone. Despite the close spatial and temporal association between the 1994 Mindoro earthquake and tsunami, previous numerical modeling suggests the need for other contributing mechanisms for the 1994 tsunami. In this study, we conducted submarine geomorphological mapping of the South Pass within the Verde Island Passage, with particular focus on identifying possible submarine mass failures. Identification of submarine features were based on Red Relief Image Map (RIMM), Topographic Position Index (topographic position index)-based landform classification, and profile and plan curvatures derived from high-resolution bathymetry data. Among the important submarine features mapped include the San Andres submarine mass failure (SASMF). The San Andres submarine mass failure has an estimated volume of 0.0483 km3 and is located within the Malaylay Submarine Canyon System in the Verde Island Passage, ∼1 km offshore of San Andres in Baco, Oriental Mindoro. We also explored two tsunami models (EQ-only and EQ+SMF) for the 1994 Mindoro tsunami using JAGURS. The source mechanisms for both models included an earthquake component based on the Mw 7.1 earthquake, while the EQ+SMF also included an additional submarine mass failure component based on the mapped San Andres submarine mass failure. Modeled wave heights from the EQ-only model drastically underestimates the observed wave heights for the 1994 Mindoro tsunami. In contrast, the EQ+SMF model tsunami wave height estimates were closer to the observed data. As such, we propose an earthquake-triggered, submarine mass failure source mechanism for the 1994 Mindoro tsunami.
Association of serum levels of Visfatin, Intelectin-1, RARRES2 and their genetic variants with bone mineral density in postmenopausal females
Authors: Tariq Sundus , Tariq Saba , Khaliq Saba , Abualhamael Shahad Abduljalil , Baig Mukhtiar
Published: November 2022

Background

Adipokines are engaged in bone physiology and regulate bone mineral density (BMD) by playing protective or cynical role in bone metabolism. The study is designed to measure and compare BMD, adipokines (retinoic acid receptor responder protein-2 RARRES2, visfatin and Intelectin-1) and their genetic variants in postmenopausal osteoporotic, osteopenic and non-osteoporotic females.

Methods

This comparative study included postmenopausal non-osteoporotic (n=72), osteopenic (n=72) and osteoporotic (n=100) females with two years of amenorrhea and age between 50 to 70 years. Gold standard DXA was used to measure BMD. Hardy-Weinberg equilibrium was established. Kruskal-Wallis test for comparisons, logistic and multivariate regression analysis were used to rule out the predictors of BMD.

Results

On comparing the three groups, significant differences were observed in serum RARRES2 (p <0.001) and serum visfatin (p=0.050). The significant positive predictor of BMD at lumbar spine and total hip was serum visfatin. BMD at right and left femoral neck was predicted negatively by serum chemerin while BMD at left femoral neck was also predicted positively by serum calcium levels. There was significant difference in BMD at right femoral neck (p = 0.033) between rs7806429 genotypes. The odds of having low BMD increases with increasing serum levels of chemerin and decreasing serum levels of visfatin and calcium

Conclusion

The adipokines RARRES2 and visfatin are associated with BMD. RARRES2 is an independent negative and visfatin is positive predictor of BMD in postmenopausal females. BMD at right femoral neck was significantly low in RARRES2 rs7806429 TC heterozygotes.
Allosteric activation of preformed EGF receptor dimers by a single ligand binding event
Authors: Purba Endang R. , Saita Ei-ichiro , Akhouri Reetesh R. , Öfverstedt Lars-Goran , Wilken Gunnar , Skoglund Ulf , Maruyama Ichiro N.
Published: November 2022

Aberrant activation of the epidermal growth factor receptor (EGFR) by mutations has been implicated in a variety of human cancers. Elucidation of the structure of the full-length receptor is essential to understand the molecular mechanisms underlying its activation. Unlike previously anticipated, here, we report that purified full-length EGFR adopts a homodimeric form in vitro before and after ligand binding. Cryo-electron tomography analysis of the purified receptor also showed that the extracellular domains of the receptor dimer, which are conformationally flexible before activation, are stabilized by ligand binding. This conformational flexibility stabilization most likely accompanies rotation of the entire extracellular domain and the transmembrane domain, resulting in dissociation of the intracellular kinase dimer and, thus, rearranging it into an active form. Consistently, mutations of amino acid residues at the interface of the symmetric inactive kinase dimer spontaneously activate the receptor in vivo. Optical observation also indicated that binding of only one ligand activates the receptor dimer on the cell surface. Our results suggest how oncogenic mutations spontaneously activate the receptor and shed light on the development of novel cancer therapies.
Performance monitoring and evaluation of water environment treatment PPP projects with multi-source heterogeneous information
Authors: Su Limin , Cao Yongchao
Published: November 2022

Effective measurement and monitoring of the quality of services from the private sector, in the terms of performance in water environment treatment public-private partnership projects (WETPs-PPP), is one of the keys to the success of these projects. Based on the deficiencies of performance monitoring and evaluation theory and the specific characteristics of WETPs-PPP, this study developed a performance monitoring and evaluation model for WETPs-PPP. First, through a literature analysis, a performance monitoring and evaluation index system of WETPs-PPP was constructed from eight dimensions including river embankment, bridges, river water, environment, garden facilities, garden plants, special purpose vehicle, hydraulic structure, and public satisfaction. Second, by combining the adaptive weighted fusion algorithm and Intuitionistic Fuzzy (IF) average operators, multi-source, multi-dimensional, and multi-spatio-temporal data were aggregated. Third, to improve the robustness of the performance monitoring results, the MULTIMOORA evaluation method with a defuzzification procedure under the IF environment was developed to conduct performance monitoring and evaluation for WETPs-PPP. Finally, a water environment treatment and ecological restoration project was used as an example to illustrate the feasibility and effectiveness of the proposed theoretical model.
Impact of socio-economic and environmental factors on livestock production in Kyrgyzstan
Authors: Yang Jiamiao , Wang Yanwen , Zhang Hao , Su Yuming , Wu Xiaoyang , Yan Shuqi , Yang Shuwang
Published: November 2022

Livestock husbandry is a key indicator of economic development, environmental protection, and food security in the world, which is vulnerable to environmental changes and economic shocks. In our study on Kyrgyzstan, we quantified the effects of socio-economic and environmental factors on the dynamics of livestock sales, self-consumption, and inventory from 2006 to 2020 using a two-period livestock production model and spatial panel model. The results showed that from 2006 to 2020, more than 50% livestock were stocked annually, which means that herders in Kyrgyzstan preferred to preserve their animals as assets to deal with unknown risks. Additionally, to gain greater profit, Kyrgyz herdsmen would expand or downsize their livestock business, tailor self-consumption, and manage inventory based on the livestock market price, loan on livestock, non-herding income, and its current stock. Our study found that the development of animal husbandry in seven oblasts of Kyrgyzstan had spatial spillover effects, which indicated that the dynamics of the animal husbandry market and environment not only affected the scale of local animal husbandry but also had an important impact on adjacent oblasts. Our research contributes to ensuring the income for herdsmen and the sustainable development of animal husbandry, thereby promoting high-quality economic development in developing countries with animal husbandry as a pillar industry.
Impact of the closure of Berlin-Tegel Airport on ultrafine particle number concentrations on the airfield
Authors: Fritz Sabine , Aust Sebastian , Sauter Tobias
Published: November 2022

Airports contribute substantially to ultrafine particle (UFP; <100 nm) concentrations on a local scale. These UFPs, which derive mainly from combustion processes, are generated during take-off and landing of aircraft, during aircraft movements on the tarmac, when engines and turbines are started, and by vehicles transporting goods and people on the airfield. UFPs are considered particularly harmful to human health as their small size enables them to pass far into the human body. This study investigates the extent to which particle number concentrations (PNCs) sized 7–2,000 nm respond to the cessation of air traffic due to the closure of a major airport. PNCs and wind data were monitored with a 5 s resolution at one location on the airfield of Berlin-Tegel Airport (TXL). The station was located 600 –640 m east of the runways and thus downwind of the runways for the predominant wind direction. Observations took place 24 h per day every day for about 3 weeks before and 3 weeks after the closure of the airport. During the measurement campaign, a total of 2,507 take-offs and landings took place. Including all wind directions, this study shows 30 %–40% lower PNCs on average, 2.5-fold lower maximum values as well as a 3-fold lower PNC spread after the closure of the airport. These differences are evident only during the day with active flight operations, and not during the nighttime flight ban. Downwind of the airfield, differences are even higher. After the closure of the airport, average PNCs drop by 70%, maxima by 85%, and variability is reduced by almost 90%. 70% lower and 30% less frequent PNC peaks occur downwind of the airport after flight operations are discontinued. This unique natural experiment allows for relatively clear conclusions about the relevance of airport operations on PNCs in the airfield area. The measurements carried out before and after the closure allow a direct comparison of the PNCs during airport operations and without any. Thus, our study reveals the change in UFP concentration that can be achieved through a reduction in flight operations.
Carbon emissions and economic growth in the Yellow River Basin: Decoupling and driving factors
Authors: Han Yan , Zhang Jiajie , Yuan Mengjie
Published: November 2022

In the context of global countries’ pursuit of sustainable development and “dual carbon” goals of China, this paper combines the Tapio decoupling model, Kaya’s equation and LMDI decomposition method to analyze the relationship between carbon emissions and economic growth and the driving factors of carbon emissions in the Yellow River Basin (YRB) of China from 2001 to 2019. It is found that the decoupling state of CO2 and economic growth in the Yellow River Basin shows a trend of expansion negative decoupling - expansion connection - weak decoupling - strong decoupling, but different regions shows some heterogeneity. The economic intensity effect and population size effect generally play a positive role in driving carbon emissions, while carbon emission intensity, industrial structure and energy structure effect play a negative role in driving carbon emissions in most years. From the regional perspective, the energy consumption structure in the middle reaches is the most important factor to promote carbon emissions. In terms of time period, the industrial structure effect is the driving factor of carbon emissions in the decoupling state overall as expansionary linkage, while it is the inhibitor of carbon emissions in the decoupling state overall as weak decoupling. This study also puts forward countermeasures such as optimize the energy structure and upgrade the industrial structure to achieve green and high-quality economic development in the YRB.
Epigenetics and genetics of hepatoblastoma: Linkage and treatment
Authors: Zhu Li-ran , Zheng Wanqun , Gao Qun , Chen Tianping , Pan Zhu-bin , Cui Wei , Cai Ming , Fang Hui
Published: November 2022

Hepatoblastoma is a malignant embryonal tumor with multiple differentiation modes and is the clearest liver malignancy in children. However, little is known about genetic and epigenetic events in Hepatoblastoma. Increased research has recently demonstrated, unique genetic and epigenetic events in Hepatoblastoma, providing insights into its origin and precise treatment. Some genetic disorders and congenital factors are associated with the risk of Hepatoblastoma development, such as the Beckwith-Wiedemann syndrome, Familial Adenomatous polyposis, and Hemihypertrophy. Epigenetic modifications such as DNA modifications, histone modifications, and non-coding RNA regulation are also essential in the development of Hepatoblastoma. Herein, we reviewed genetic and epigenetic events in Hepatoblastoma, focusing on the relationship between these events and cancer susceptibility, tumor growth, and prognosis. By deciphering the genetic and epigenetic associations in Hepatoblastoma, tumor pathogenesis can be clarified, and guide the development of new anti-cancer drugs and prevention strategies.
Establishing a model fish for the Neotropical region: The case of the yellowtail tetra Astyanax altiparanae in advanced biotechnology
Authors: Yasui George Shigueki , Ferreira do Nascimento Nivaldo , Pereira-Santos Matheus , Santos Silva Amanda Pereira dos , Coelho Geovanna Carla Zacheo , Visintin José Antônio , Porto-Foresti Fábio , Okada Nakaghi Laura Satiko , Vianna Norberto Castro , Carvalho Gabriela Braga , Monzani Paulo Sérgio , López Lucia Suárez , Senhorini José Augusto
Published: November 2022

The use of model organisms is important for basic and applied sciences. Several laboratory species of fishes are used to develop advanced technologies, such as the zebrafish (Danio rerio), the medaka (Oryzias latipes), and loach species (Misgurnusspp.). However, the application of these exotic species in the Neotropical region is limited due to differences in environmental conditions and phylogenetic distances. This situation emphasizes the establishment of a model organism specifically for the Neotropical region with the development of techniques that may be applicable to other Neotropical fish species. In this work, the previous research efforts are described in order to establish the yellowtail tetraAstyanax altiparanaeas a model laboratory species for both laboratory and aquaculture purposes. Over the last decade, starting with artificial fertilization, the yellowtail tetra has become a laboratory organism for advanced biotechnology, such as germ cell transplantation, chromosome set manipulation, and other technologies, with applications in aquaculture and conservation of genetic resources. Nowadays, the yellowtail tetra is considered the most advanced fish with respect to fish biotechnology within the Neotropical region. The techniques developed for this species are being used in other related species, especially within the characins class.
Human B-1 cells are important contributors to the naturally-occurring IgM pool against the tumor-associated ganglioside Neu5GcGM3
Authors: Rodriguez-Zhurbenko Nely , Quach Tam D. , Rothstein Thomas L. , Hernandez Ana M.
Published: November 2022

Only few studies have described the anti-tumor properties of natural antibodies (NAbs). In particular, natural IgM have been linked to cancer immunosurveillance due to its preferential binding to tumor-specific glycolipids and carbohydrate structures. Neu5GcGM3 ganglioside is a sialic acid–containing glycosphingolipid that has been considered an attractive target for cancer immunotherapy, since it is not naturally expressed in healthy human tissues and it is overexpressed in several tumors. Screening of immortalized mouse peritoneal-derived hybridomas showed that peritoneal B-1 cells contain anti-Neu5GcGM3 antibodies on its repertoire, establishing a link between B-1 cells, NAbs and anti-tumor immunity. Previously, we described the existence of naturally-occurring anti-Neu5GcGM3 antibodies with anti-tumor properties in healthy young humans. Interestingly, anti-Neu5GcGM3 antibodies level decreases with age and is almost absent in non-small cell lung cancer patients. Although anti-Neu5GcGM3 antibodies may be clinically relevant, the identity of the human B cells participating in this anti-tumor antibody response is unknown. In this work, we found an increased percentage of circulating human B-1 cells in healthy individuals with anti-Neu5GcGM3 IgM antibodies. Furthermore, anti-Neu5GcGM3 IgMs were generated predominantly by human B-1 cells and the antibodies secreted by these B-1 lymphocytes also recognized Neu5GcGM3-positive tumor cells. These data suggest a protective role for human B-1 cells against malignant transformation through the production of NAbs reactive to tumor-specific antigens such as Neu5GcGM3 ganglioside.
Projecting future climate change impacts on the distribution of the ‘Octopus vulgaris species complex’
Authors: Borges Francisco Oliveira , Guerreiro Miguel , Santos Catarina Pereira , Paula José Ricardo , Rosa Rui
Published: November 2022

Introduction

Historically considered to be a single cosmopolitan species, the so calledOctopus vulgarisspecies complex (OVSC) is now recognized to be a group of (at least) six cryptic species:O. americanus(in the west Atlantic),O. vulgaris(in the northeast Atlantic and Mediterranean Sea),O.aff. vulgaris(in the region of South Africa),O. tetricus(southeastern Oceania),O. sinensis(northwestern Pacific), andO. djinda(western Australia). The potentially different environmental preferences of this highly cryptic species complex may result in distinct consequences under future environmental conditions.

Methods

The present study employed species distribution models (SDM) using MaxEnt to investigate potential changes in habitat suitability and geographical distribution of the OVSC in the future (i.e., 2050, and 2100), across four representative concentration pathway scenarios (RCP-2.6, 4.5, 6.0, and 8.5, CMIP5).

Results

Differential responses were observed in the OVSC species analyzed. Specifically,O. vulgarisandO. tetricusexhibited a severe loss in distribution across their predicted range;O. americanusexhibited projected extirpation close to the equator, with limited expansion towards the poles;O.aff. vulgariswas projected to lose half of its current distribution;O. sinensisexhibited moderate losses, with projected increases in northern areas; and finally,O. djindaexhibited limited losses to its distribution. Except forO. sinensis, increasing RCP severity exacerbated changes in mean habitat suitability and projected distribution gains and losses.

Discussion

Ultimately, this study provides information on the potential biogeographical effects of marine climate change on a key worldwide ecological and economic resource to further disentangle the effects over each OVSC species, with the goal of assisting toward the sustainable management of octopus species at the global scale.
Metabarcoding reveals the differential sensitivity of planktonic microbiome to environmental filtering and biointeraction in Sansha Yongle blue hole
Authors: Chen Tianying , Zhuang Yunyun , Chen Chang , Mao Xuewei , Ge Ruping , Chen Hongju , Chen Jianwei , Fu Liang , Yang Zuosheng , Liu Guangxing
Published: November 2022

The Sansha Yongle blue hole (SYBH) is the world’s deepest blue hole known so far and its unique hydrochemical characteristics make it a valuable site for studying biodiversity and ecological processes. Here, we used metabarcoding approach to investigate the diversity, assembly mechanism and co-occurrence pattern of planktonic microbiome in SYBH. Our results revealed the distinct separation of communities from upper oxic, middle oxic and suboxic-anoxic layer and significant day-night difference was detected in the upper-layer community of microeukaryotes, indicating potential diel migration. Stochastic processes played a significant role in the community assembly of microeukaryotes, while deterministic processes dominated in prokaryotes, confirming the stronger environmental filtering on prokaryotes as also suggested by the correlation with environmental variables. Microeukaryotes were less sensitive to environments but significantly affected by cross-domain biointeraction. When comparing the subcommunities of different abundance, we found that abundant taxa were widespread while rare taxa were habitat-specific. In co-occurrence network, over 87% of the interactions and 19 out of 20 keystone OTUs (Operational Taxonomic Units) were affiliated to moderate or rare taxa, suggesting the importance of non-abundant taxa in maintaining community stability. The predominant positive edges in the network pointed to that interspecies cooperation may be one of the ecological strategies in SYBH. Overall, we highlight the divergent assembly pattern and different driving forces in shaping plankton microbiome in SYBH, which may advance current understanding on diversity and dynamics of marine life in blue hole ecosystems.
Electro-chemo-mechanics of solid state batteries with lithium plating and stripping
Authors: Cabras L. , Serpelloni M. , Salvadori A.
Published: November 2022

This note is about a novel, thermodynamically consistent formulation for small strains continuum electro-chemo-mechanics applied to all solid state batteries, which are claimed to be the next-generation battery system in view of their safety accompanied by high energy densities. The response of a cell, made of a lithium metal foil, a solid electrolyte, and a porous LiCoO2 cathode, has been investigated in terms of quantities of interest such as the electric potential, the lithium concentrations profiles, displacements, and stresses. The plating and stripping of the lithium has been considered together with the volumetric evolution of the porous cathode. Together they contribute to the outbreak of mechanical stresses, which may influence the life cycle of a battery.
A case study on dome structure of composite structural insulation panels with ANSYS simulations
Authors: Liang Chunhang , Zhu Liming
Published: November 2022

Thin-shell dome structures are conventionally built with concrete. However, the building process is time-consuming and of high labor cost. Composite Structural Insulation Panels (CSIPs) have recently been regarded to be suitable for large-span civil structures, in terms of its light weight, easy processing, and mass production. Hence, this paper explores the feasibility of CSIPs domes applied in large-span dome structures. Compared with the performance of thin-shell concrete domes, the stiffness, strength, and stability of CSIPs domes are studied by means of refined finite element analysis. Results demonstrate CSIPs dome possesses good dynamic performance, bears larger nonlinear loads, and even copes with stress loads under earthquakes. Moreover, the stiffness should be handled in the onsite applications to fulfil the safety requirements.
Current uses of electro-cautery lumen apposing metal stents in endoscopic ultrasound guided interventions
Authors: Yi Hang , Liu Qin , He Song , Zhong Li , Wu Su-hua , Guo Xiao-dong , Ning Bo
Published: November 2022

The electro-cautery lumen apposing metal stent (EC-LAMS) is a newly developed device that integrates the electro-cautery cyctotome with the one-step metal stent delivery and releasing system in recent years. LAMS was first designed to complete the drainage of pancreatic fluid collection under endoscopic ultrasound guidance, and the technological innovation of EC-LAMS has made more off-labeled indications of endoscopic intervention for gastrointestinal diseases realized, such as abdominal fluid drainage, bile duct, or gallbladder drainage through stomach or duodenum, gastrointestinal anastomosis, and the establishment of fistulous channel for further endoscopic operation when necessary. The unique feature of this metal stent is that it has the design of a saddle shape and a large lumen, and can almost connect the adjacent structures to minimize the risk of perforation and leakage. Compared with traditional LAMS, EC-LAMS, an advanced integrated device, can greatly simplify the endoscopic process, shorten the procedure time and reduce the technical difficulty, thus it can help endoscopists complete more complex endoscopic interventions. In this review, we discuss the state of art with regard to EC-LAMS and its endoscopic process, current indications, outcomes, adverse events, and future application prospects.