bluuebunny/crossref_metadata_2025 huggingface dataset:
Lost but Not Least—Novel Insights into Progesterone Receptor Loss in Estrogen Receptor-Positive Breast Cancer
Authors: Kunc Michał , Popęda Marta , Biernat Wojciech , Senkus Elżbieta
Published: September 2021

Estrogen receptor α (ERα) and progesterone receptor (PgR) are crucial prognostic and predictive biomarkers that are usually co-expressed in breast cancer (BC). However, 12–24% of BCs present ERα(+)/PgR(−) phenotype at immunohistochemical evaluation. In fact, BC may either show primary PgR(−) status (in chemonaïve tumor sample), lose PgR expression during neoadjuvant treatment, or acquire PgR(−) phenotype in local relapse or metastasis. The loss of PgR expression in ERα(+) breast cancer may signify resistance to endocrine therapy and poorer outcomes. On the other hand, ERα(+)/PgR(−) BCs may have a better response to neoadjuvant chemotherapy than double-positive tumors. Loss of PgR expression may be a result of pre-transcriptional alterations (copy number loss, mutation, epigenetic modifications), decreased transcription of the PGR gene (e.g., by microRNAs), and post-translational modifications (e.g., phosphorylation, sumoylation). Various processes involved in the down-regulation of PgR have distinct consequences on the biology of cancer cells. Occasionally, negative PgR status detected by immunohistochemical analysis is paradoxically associated with enhanced transcriptional activity of PgR that might be inhibited by antiprogestin treatment. Identification of the mechanism of PgR loss in each patient seems challenging, yet it may provide important information on the biology of the tumor and predict its responsiveness to the therapy.
Obesity-Independent Association between Glycemic Status and the Risk of Hematologic Malignancy: A Nationwide Population-Based Longitudinal Cohort Study
Authors: Kang Jihun , Jin Sang-Man , Kim Seok Jin , Kim Dahye , Han Kyungdo , Jeong Su-Min , Chang JiWon , Rhee Sang Youl , Choi Taewoong , Shin Dong Wook
Published: September 2021

There have been conflicting results regarding the association between diabetes and the risk of hematologic malignancies, and its interaction with obesity is unknown. This study determined the risk of hematologic malignancies according to the glycemic status in a population-based study involving health screening 9,774,625 participants. The baseline glycemic status of the participants was categorized into no diabetes, impaired fasting glucose (IFG), newly detected diabetes, diabetes duration <5 years, and diabetes duration ≥5 year groups. The risks of overall and specific hematologic malignancies were estimated using a Cox regression analysis. During a median follow up of 7.3 years, 14,733 hematologic malignancies developed. The adjusted hazard ratio (aHR) for the risk of all the hematologic malignancies was 0.99 (95% confidence interval (CI) 0.95–1.02) for IFG, 0.99 (95% CI 0.91–1.08) for newly detected diabetes, 1.03 (95% CI 0.96–1.11) for diabetes duration <5 years, and 1.11 (95% CI 1.03, 1.20) for diabetes duration ≥5 year groups. The association was independent from obesity. The risk of non-Hodgkin’s lymphoma (NHL) increased according to the progression of dysglycemia towards a longer diabetes duration, while Hodgkin’s lymphoma did not. This study in Korea demonstrated diabetes to be associated with an increased risk of hematologic malignancies independent of obesity. The NHL risk increased with the diabetes duration.
Rapid Microwave-Assisted Synthesis of Fe3O4/SiO2/TiO2 Core-2-Layer-Shell Nanocomposite for Photocatalytic Degradation of Ciprofloxacin
Authors: Gabelica Ivana , Ćurković Lidija , Mandić Vilko , Panžić Ivana , Ljubas Davor , Zadro Krešo
Published: September 2021

In this work, magnetic nanoparticles based on magnetite were successfully prepared via rapid microwave-assisted synthesis. In order to obtain the ternary core–shell Fe3O4/SiO2/TiO2 nanocomposite, first magnetite (Fe3O4) nanoparticles were coated with a protective layer of silica (SiO2) and finally with titania (TiO2). The composite configuration comprising porous and photoactive shells should facilitate the removal of organic micropollutants (OMPs) from water. Furthermore, the magnetic core is critical for processing the management of the photocatalytic powder suspension. The magnetization of the prepared magnetic nanoparticles was confirmed by vibrating-sample magnetometry (VSM), while the structure and morphology of the core–shell nanocomposite were investigated by means of XRD, FTIR, and SEM. Adsorption and photocatalysis were evaluated by investigating the removal efficiency of ciprofloxacin (CIP) as a model OMP using the prepared magnetic core–shell nanocomposite under UV-A light irradiation. It was found that the Fe3O4/SiO2/TiO2 nanocomposite showed good synergistic adsorption and photocatalytic properties. The measurement of iron in eluate confirmed that no leaching occurred during the photocatalytic examination. The recovery of magnetic nanocomposite by an external magnetic field confirmed that the magnetically separated catalyst is highly suitable for recycling and reuse.
Relationship between Acidity and Activity on Propane Conversion over Metal-Modified HZSM-5 Catalysts
Authors: Zhou Hao , Zhang Fucan , Ji Keming , Gao Junhua , Liu Ping , Zhang Kan , Wu Se
Published: September 2021

A systematic study of the comparative performances of different metal-impregnated HZSM-5 catalysts (Zn, Ga, Mo, Co, and Zr) for propane conversion is presented. The physicochemical properties of catalysts were characterized by means of XRD, BET, SEM, TEM, FTIR, XPS, 27Al MAS NMR, NH3-TPD and Py-FTIR. It was found that the acidities of the catalysts were significantly influenced by loading metal. More specifically, Mo-, Co- or Zr-modified catalysts showed a large metal size and low acidic density, resulting high olefin selectivity, while Zn- or Ga-modified catalysts maintained their small metal size and acidic density, and mainly reduced B/L due to the Lewis acid sites created by Zn or Ga species, resulting in high aromatics selectivity. Experimental results also showed that there is a balance between metals size and medium and strong acidity on propane conversion. Moreover, based on the different acidity of metal-modified HZSM-5 catalysts, the mechanism of propane conversion was also discussed.
Dabigatran Etexilate Induces Cytotoxicity in Rat Gastric Epithelial Cell Line via Mitochondrial Reactive Oxygen Species Production
Authors: Kurokawa Hiromi , Taninaka Atsushi , Shigekawa Hidemi , Matsui Hirofumi
Published: September 2021

Dabigatran is a novel oral anticoagulant that directly inhibits free and fibrin-bound thrombins and exerts rapid and predictable anticoagulant effects. While the use of this reagent has been associated with an increased risk of gastrointestinal bleeding, the reason why dabigatran use increases gastrointestinal bleeding risk remains unknown. We investigated the cytotoxicity of dabigatran etexilate and tartaric acid, the two primary components of dabigatran. The cytotoxicity of dabigatran etexilate and tartaric acid was measured in a cell viability assay. Intracellular mitochondrial reactive oxygen species (mitROS) production and lipid peroxidation were measured using fluorescence dyes. Cell membrane viscosity was measured using atomic force microscopy. The potential of ascorbic acid as an inhibitor of dabigatran cytotoxicity was also evaluated. The cytotoxicity of dabigatran etexilate was higher than that of tartaric acid. Dabigatran etexilate induced mitROS production and lipid peroxidation and altered the cell membrane viscosity. Ascorbic acid inhibited the cytotoxicity and mitROS production induced by dabigatran etexilate. Therefore, we attributed the cytotoxicity of dabigatran to dabigatran etexilate, and proposed that the cytotoxic effects of dabigatran etexilate are mediated via mitROS production. Additionally, we demonstrated that dabigatran cytotoxicity can be prevented via antioxidant treatment.
Do Mast Cells Contribute to the Antifungal Host Defense?
Authors: Żelechowska Paulina , Pastwińska Joanna , Brzezińska-Błaszczyk Ewa , Agier Justyna
Published: September 2021

The fungal kingdom includes a group of microorganisms that are widely distributed in the environment, and therefore the exposure to them is almost constant. Furthermore, fungal components of the microbiome, i.e., mycobiome, could serve as a reservoir of potentially opportunistic pathogens. Despite close encounters with fungi, defense mechanisms that develop during fungal infections remain unexplored. The strategic location of mast cells (MCs) close to the external environment places them among the first cells to encounter pathogens along with the other innate immune cells. MCs are directly involved in the host defense through the ability to destroy pathogens or indirectly by activating other immune cells. Most available data present MCs’ involvement in antibacterial, antiviral, or antiparasitic defense mechanisms. However, less is known about their contribution in defense mechanisms against fungi. MCs may support immune responses to fungi or their specific molecules through initiated degranulation, synthesis and release of cytokines, chemokines, mediators, and generation of reactive oxygen species (ROS), as well as immune cells’ recruitment, phagocytosis, or provision of extracellular DNA traps. This review summarizes current knowledge on host defense mechanisms against fungi and MCs’ involvement in those processes. It also describes the effects of fungi or fungus-derived constituents on MCs’ activity.
Early Effects of HTLV-1 Infection on the Activation, Exhaustion, and Differentiation of T-Cells in Humanized NSG Mice
Authors: Espíndola Otávio de Melo , Siteur-van Rijnstra Esther , Frankin Esmay , Weijer Kees , van der Velden Yme Ubeles , Berkhout Ben , Blom Bianca , Villaudy Julien
Published: September 2021

Adult T-cell leukemia/lymphoma (ATLL) is an aggressive malignancy of CD4+ T-cells associated with HTLV-1 infection. In this study, we used the model of immunodeficient NSG mice reconstituted with a functional human immune system (HIS) to investigate early events in HTLV-1 pathogenesis. Upon infection, human T-cells rapidly increased in the blood and lymphoid tissues, particularly CD4+CD25+ T-cells. Proliferation of CD4+ T-cells in the spleen and mesenteric lymph nodes (MLN) correlated with HTLV-1 proviral load and CD25 expression. In addition, splenomegaly, a common feature of ATLL in humans, was also observed. CD4+ and CD8+ T-cells predominantly displayed an effector memory phenotype (CD45RA−CCR7−) and expressed CXCR3 and CCR5 chemokine receptors, suggesting the polarization into a Th1 phenotype. Activated CD8+ T-cells expressed granzyme B and perforin; however, the interferon-γ response by these cells was limited, possibly due to elevated PD-1 expression and increased frequency of CD4+FoxP3+ regulatory T-cells in MLN. Thus, HTLV-1-infected HIS-NSG mice reproduced several characteristics of infection in humans, and it may be helpful to investigate ATLL-related events and to perform preclinical studies. Moreover, aspects of chronic infection were already present at early stages in this experimental model. Collectively, we suggest that HTLV-1 infection modulates host immune responses to favor viral persistence.
Plasma Membrane and Organellar Targets of STIM1 for Intracellular Calcium Handling in Health and Neurodegenerative Diseases
Authors: Tedeschi Valentina , La Russa Daniele , Franco Cristina , Vinciguerra Antonio , Amantea Diana , Secondo Agnese
Published: September 2021

Located at the level of the endoplasmic reticulum (ER) membrane, stromal interacting molecule 1 (STIM1) undergoes a complex conformational rearrangement after depletion of ER luminal Ca2+. Then, STIM1 translocates into discrete ER-plasma membrane (PM) junctions where it directly interacts with and activates plasma membrane Orai1 channels to refill ER with Ca2+. Furthermore, Ca2+ entry due to Orai1/STIM1 interaction may induce canonical transient receptor potential channel 1 (TRPC1) translocation to the plasma membrane, where it is activated by STIM1. All these events give rise to store-operated calcium entry (SOCE). Besides the main pathway underlying SOCE, which mainly involves Orai1 and TRPC1 activation, STIM1 modulates many other plasma membrane proteins in order to potentiate the influxof Ca2+. Furthermore, it is now clear that STIM1 may inhibit Ca2+ currents mediated by L-type Ca2+ channels. Interestingly, STIM1 also interacts with some intracellular channels and transporters, including nuclear and lysosomal ionic proteins, thus orchestrating organellar Ca2+ homeostasis. STIM1 and its partners/effectors are significantly modulated in diverse acute and chronic neurodegenerative conditions. This highlights the importance of further disclosing their cellular functions as they might represent promising molecular targets for neuroprotection.
Nanosecond Q-Switched 1064/532 nm Laser to Treat Hyperpigmentations: A Double Center Retrospective Study
Authors: Nisticò Steven Paul , Cannarozzo Giovanni , Provenzano Eugenio , Tamburi Federica , Fazia Gilda , Sannino Mario , Negosanti Francesca , Del Duca Ester , Patruno Cataldo , Bennardo Luigi
Published: September 2021

(1) Benign hyperpigmentations are a common problem in cosmetic dermatology. Melasma, solar lentigo, and other acquired hyperpigmentations represent an aesthetic issue for an increasing number of patients. The gold standard in managing this condition is currently 1064/532 nanometers (nm) Q-Switched lasers. This study reports our experience on the use of a Q-switched laser with a nanosecond pulse to treat these conditions. (2) Methods: A total of 96 patients asking for benign hyperpigmentation removal were consecutively enrolled at the Magna Graecia University of Catanzaro and Tor Vergata University of Rome. Treating parameters were the following: 1064 nm with a pulse duration of 6 nanoseconds (ns) for dermic lesions and 532 nm with 6 ns for epidermal ones. Up to five treatments with a minimum interval between laser treatments of thirty days were performed. A follow-up visit three months after the last session assessed patient satisfaction with a Visual Analogue Scale (VAS). Two blinded dermatologists assessed the cosmetic result using a five-point scale comparing pictures before treatment and at follow-up. (3) Results: 96 patients were included; 47 participants were women (49.0%) and 49 men (51.0%). The mean reported age was 50.0 ± 17.3 years. All patients reached a good to complete hyperpigmentation removal at the dermatological evaluation with a mean VAS score of 8.91 ± 1.07. (4) Conclusions: Q Switched 1064/532 nm laser may be considered the gold standard treatment for benign hyperpigmentations. Our results confirm the literature findings on the effectiveness of these devices.
Applying Artificial Intelligence to Improve On-Site Non-Destructive Concrete Compressive Strength Tests
Authors: Ngo Tu Quynh Loan , Wang Yu-Ren , Chiang Dai-Lun
Published: September 2021

In the construction industry, non–destructive testing (NDT) methods are often used in the field to inspect the compressive strength of concrete. NDT methods do not cause damage to the existing structure and are relatively economical. Two popular NDT methods are the rebound hammer (RH) test and the ultrasonic pulse velocity (UPV) test. One major drawback of the RH test and UPV test is that the concrete compressive strength estimations are not very accurate when comparing them to the results obtained from the destructive tests. To improve concrete strength estimation, the researchers applied artificial intelligence prediction models to explore the relationships between the input values (results from the two NDT tests) and the output values (concrete strength). In-situ NDT data from a total of 98 samples were collected in collaboration with a material testing laboratory and the Professional Civil Engineer Association. In-situ NDT data were used to develop and validate the prediction models (both traditional statistical models and AI models). The analysis results showed that AI prediction models provide more accurate estimations when compared to statistical regression models. The research results show significant improvement when AI techniques (ANNs, SVM and ANFIS) are applied to estimate concrete compressive strength in RH and UPV tests.
Diffusion Bonding of FGH 98 and CoCrNi-Based Medium-Entropy Alloy: Microstructure Evolution and Mechanical Tests
Authors: Du Yajie , Li Zhaoxi , Xiong Jiangtao , Chen Yipeng , Li Shiwei , Li Jinglong , Dong Jihong
Published: September 2021

The superalloy FGH98 was successfully diffusion bonded (DB) with medium-entropy alloy (MEA) Al3Ti3(CrCoNi)94 using pure Ni as the interlayer at a temperature range of 1050–1170 °C for 1 h under 5 MPa. The microstructure and mechanical properties of joints were investigated. The diffusion bonding seam was composed of an interlayer zone (IZ) and two diffusion-affected zones (DAZ). The IZ and DAZ beside the FGH98 consisted of cubic Ni3(TiAl)-type γ′ phases due to the diffusion of Ti and Al atoms. Meanwhile, the DAZ adjacent to the MEA consisted of spherical γ′ phases. Both of the γ′ phases with different morphology kept the coherent relationship with the matrix. Moreover, increase of bonding temperature led to the morphology of interlayer γ′ phase to transform from sphere to cube. Due to the strengthening effect of a mass of γ′ phase distributed evenly in IZ and the DAZ beside the FGH98, the microhardness and Young’s modulus of these two zones were higher than that of DAZ near the MEA. The maximum shear strength of DB joint, 592 MPa, was achieved in the joint bonded by 1150 °C, which was the typical ductile fracture feature confirmed by the shear dimples.
Coupled InGaAs Quantum Dots for Electro-Optic Modulation
Authors: Chuang Kuei-Ya , Tzeng Te-En , Lay Tsong-Sheng
Published: September 2021

We investigated the growth of vertically coupled In0.75Ga0.25As quantum dots (QDs) by varying the GaAs spacer thickness (d). Vertically-aligned triple-layer QDs of uniform size and highest accumulated strain are formed with d = 5 nm. The electroluminescence (EL) characteristics for In0.75Ga0.25As QDs show an emission spectrum at optical wavelength (λ) of 1100−1300 nm. The EL spectra exhibit the highest optical gain at λ ~ 1200 nm, and the narrowest FWHM = 151 nm of the sample with d = 5 nm at injection current = 20 mA. Fabry–Perot measurements at λ = 1515 nm of TE and TM polarizations were carried out to investigate the electro-optic modulation for a single-mode ridge waveguide consisting of vertically-coupled triple-layer In0.75Ga0.25As QDs (d = 5 nm). The linear (r) and quadratic (s) electro-optic coefficients are r = 2.99 × 10−11 m/V and s = 4.10 × 10−17 m2/V2 for TE polarization, and r = 1.37 × 10−11 m/V and s = 3.2 × 10−17 m2/V2 for TM polarization, respectively. The results highlight the potential of TE/TM lightwave modulation by InGaAs QDs at photon energy below energy band resonance.
Assessing Distribution Patterns and the Relative Abundance of Reintroduced Large Herbivores in the Limpopo National Park, Mozambique
Authors: Roque Dionísio Virgílio , Göttert Thomas , Macandza Valério António , Zeller Ulrich
Published: September 2021

This study is the first systematic assessment of large herbivore (LH) communities in Limpopo National Park (LNP) in Mozambique, an area where most LH species were extinct until the early 2000s. We investigate whether LH community parameters are linked with the availability of habitat types or the distance between sampling sites and the origin of LH resettlement. We placed camera traps in five habitat types in resettled and not-resettled areas to compare species richness, relative abundance index, grazers–browsers–mixed feeder and naïve occupancy of 15 LH species. While the richness decreased along the distance gradient of LH resettlement, relative abundance index strongly responded to habitat features. The grazer–browser–mixed feeder ratio oscillated, while from resettled to not-resettled areas, the ratio increased. Most species show a wide distribution range. The associations of most LH community parameters with habitat types rather than distance to initial release, together with the species-specific and guild-specific response patterns of LH, suggest LNP to already be in an intermediate stage of restoration. Our results highlight the importance of post-release monitoring of reintroduced wildlife as a tool to assess the success of ecological restoration initiatives in transboundary conservation areas.
A Mysterious World Revealed: Larval-Adult Matching of Deep-Sea Shrimps from the Gulf of Mexico
Authors: Varela Carlos , Bracken-Grissom Heather
Published: September 2021

The identification of deep-sea (>200 m) pelagic larvae is extremely challenging due to the morphological diversity across ontogeny and duration of larval phases. Within Decapoda, developmental stages often differ conspicuously from their adult form, representing a bizarre and mysterious world still left to be discovered. The difficulties with sampling and rearing deep-sea larvae, combined with the lack of taxonomic expertise, argues for the use of molecular methods to aid in identification. Here, we use DNA barcoding combined with morphological methods, to match larval stages with their adult counterpart from the northern Gulf of Mexico and adjacent waters. For DNA barcoding, we targeted the mitochondrial ribosomal large subunit 16S (16S) and the protein coding cytochrome oxidase subunit 1 (COI). These data were combined with previous sequences to generate phylogenetic trees that were used to identify 12 unknown larval and two juvenile species from the infraorder Caridea and the suborder Dendrobranchiata. Once identified, we provide taxonomic descriptions and illustrations alongside the current state of knowledge for all families. For many groups, larval descriptions are missing or non-existent, so this study represents a first step of many to advance deep-sea larval diversity.
Assessment of 3D Lumbosacral Vascular Anatomy for OLIF51 by Non-Enhanced MRI and CT Medical Image Fusion Technique
Authors: Nagamatsu Masakazu , Ruparel Sameer , Tanaka Masato , Fujiwara Yoshihiro , Uotani Koji , Arataki Shinya , Yamauchi Taro , Takeshita Yoshiyuki , Takamoto Rika , Tanaka Masato , Moriue Shinsuke
Published: September 2021

Study design: Prospective study. Objective: Medical image fusion can provide information from multiple modalities in a single image. The present study aimed to determine whether three-dimensional (3D) lumbosacral vascular anatomy could be adequately portrayed using a non-enhanced CT–MRI medical image fusion technique. Summary of Background Data: Lateral lumbar interbody fusion has gained popularity for the surgical treatment of adult spinal deformity (ASD). Oblique lumbar interbody fusion at L5–S1 (OLIF51) is receiving considerable attention as a method of creating good L5–S1 lordosis. Access in OLIF51 requires evaluation of the vascular anatomy in the lumbosacral region. Conventional imaging modalities need a contrast medium to describe the vascular anatomy. Methods: Participants comprised 15 patients with ASD or degenerative lumbar disease who underwent corrective surgery at our hospital between January 2020 and June 2021. A 3D vascular image with bony structures was obtained by fusing results from MRI and CT. We processed the merged image and measured the distance between left and right common iliac arteries and veins at two levels: the lower end of the L5 vertebral body (Window A) and the upper end of the S1 vertebral body (Window B). Results: The mean sizes of Window A and Window B were 29.7 ± 10.7 mm and 36.9 ± 10.3 mm, respectively. The mean distance from the bifurcation to the lower end of the L5 vertebra was 23.7 ± 10.9 mm. Coronal deviation of the bifurcation was, from center to left, 12.6 ± 12.3 mm, and the distance from the center of the L5 vertebral body to the bifurcation was 0.79 ± 7.3 mm. Only one case showed a median sacral vein (6.7%). Clinically, we performed OLIF51 in 12 of the 15 cases (80%). Conclusion: Evaluating 3D lumbosacral vascular anatomy using a non-enhanced MRI and CT medical image fusion technique is very useful for OLIF51, particularly for patients in whom the use of contrast medium is contraindicated.
Bioelectrical Impedance Analysis Derived-Phase Angle as a Pragmatic Tool to Detect Protein Energy Wasting among Multi-Ethnic Hemodialysis Patients
Authors: Lim Cordelia-Kheng-May , Lim Jun-Hao , Ibrahim Imliya , Chan Yoke-Mun , Zakaria Nor Fadhlina , Yahya Rosnawati , Daud Zulfitri Azuan Mat
Published: September 2021

Protein-energy wasting (PEW) is a devastating metabolic derangement that leads to increased morbidity and mortality in hemodialysis (HD) patients. This study aimed to determine the diagnostic test accuracy of bioelectrical impedance analysis derived-phase angle (PhA) in detecting PEW among HD patients. This was a multi-centre, cross-sectional study conducted amongst 152 multi-ethnic HD patients in Klang Valley, Malaysia. PEW was assessed using the International Society of Renal Nutrition and Metabolism criteria as the reference method. PhA was measured using a multi-frequency bioelectrical impedance spectroscopy at 50 kHz. Multiple and logistic regressions were used to determine factors associated with PhA and PEW diagnosis, respectively. A receiver operating characteristics curve analysis was used to establish the gender-specific PhA cut-offs to detect PEW. PEW existed in 21.1% of the HD patients. PhA was found as an independent predictor of PEW (adjOR = 0.308, p = 0.001), with acceptable to excellent discriminative performance (adjAUCmale = 0.809; adjAUCfemale = 0.719). Male patients had higher PhA cut-off compared to female patients (4.26° vs. 3.30°). We concluded that PhA is a valid and pragmatic biomarker to detect PEW in multi-ethnic Malaysian HD patients and a gender-specific cut-off is necessary, attributed to the gender differences in body composition.
COVID-19 Associated Mucormycosis: A Systematic Review from Diagnostic Challenges to Management
Authors: Yasmin Farah , Najeeb Hala , Naeem Aisha , Dapke Kartik , Phadke Rachana , Asghar Muhammad Sohaib , Shah Syed Muhammad Ismail , De Berardis Domenico , Ullah Irfan
Published: September 2021

The coronavirus disease 2019 (COVID-19) outbreak has caused significant destruction, claiming over three million lives worldwide. Post SARS-COV-2 invasion, immunosuppression with hyperglycemia and elevated ferritin levels along with steroidal treatment creates a perfect storm for opportunistic infections. There is increasing evidence of mucormycosis co-infection in COVID-19 patients, during or post-treatment. A worse prognosis, a late diagnosis, and limited guidelines of screening and management of COVID-19 associated mucormycosis have made healthcare professionals fear an epidemic alongside a pandemic. This review geographically reports cases of COVID-19 associated mucormycosis (CAM), evaluates characteristics, clinical manifestations, and outcomes of mucormycosis in COVID-19 active or recovered patients. It further describes preventive strategies and recommendations for optimal management therapy that can be adopted worldwide to curtail an impending threat to the healthcare system.
Investigation of Patient-Specific Maxillofacial Implant Prototype Development by Metal Fused Filament Fabrication (MF3) of Ti-6Al-4V
Authors: Shaikh Mohammad Qasim , Nath Subrata Deb , Akilan Arulselvan Arumugam , Khanjar Saleh , Balla Vamsi Krishna , Grant Gerald Thomas , Atre Sundar Vedanarayanan
Published: September 2021

Additive manufacturing (AM) and related digital technologies have enabled several advanced solutions in medicine and dentistry, in particular, the design and fabrication of patient-specific implants. In this study, the feasibility of metal fused filament fabrication (MF3) to manufacture patient-specific maxillofacial implants is investigated. Here, the design and fabrication of a maxillofacial implant prototype in Ti-6Al-4V using MF3 is reported for the first time. The cone-beam computed tomography (CBCT) image data of the patient’s oral anatomy was digitally processed to design a 3D CAD model of the hard tissue and fabricate a physical model by stereolithography (SLA). Using the digital and physical models, bone loss condition was analyzed, and a maxillofacial implant initial design was identified. Three-dimensional (3D) CAD models of the implant prototypes were designed that match the patient’s anatomy and dental implant requirement. In this preliminary stage, the CAD models of the prototypes were designed in a simplified form. MF3 printing of the prototypes was simulated to investigate potential deformation and residual stresses. The patient-specific implant prototypes were fabricated by MF3 printing followed by debinding and sintering using a support structure for the first time. MF3 printed green part dimensions fairly matched with simulation prediction. Sintered parts were characterized for surface integrity after cutting the support structures off. An overall 18 ± 2% shrinkage was observed in the sintered parts relative to the green parts. A relative density of 81 ± 4% indicated 19% total porosity including 11% open interconnected porosity in the sintered parts, which would favor bone healing and high osteointegration in the metallic implants. The surface roughness of Ra: 18 ± 5 µm and a Rockwell hardness of 6.5 ± 0.8 HRC were observed. The outcome of the work can be leveraged to further investigate the potential of MF3 to manufacture patient-specific custom implants out of Ti-6Al-4V.
Trapezoidal-Type Inequalities for Strongly Convex and Quasi-Convex Functions via Post-Quantum Calculus
Authors: Kalsoom Humaira , Vivas-Cortez Miguel , Latif Muhammad Amer
Published: September 2021

In this paper, we establish new (p,q)κ1-integral and (p,q)κ2-integral identities. By employing these new identities, we establish new (p,q)κ1 and (p,q)κ2- trapezoidal integral-type inequalities through strongly convex and quasi-convex functions. Finally, some examples are given to illustrate the investigated results.
Encounters in and with Summer Camps—Happy Childhood, Alternative Bildung, or What?
Authors: Afonkina Iuliia , Bigell Werner , Chernik Valerii , Ekeland Torun Granstrøm , Kuzmicheva Tatiana , Stien Kirsten Elisabeth , Zoglowek Herbert
Published: September 2021

Although they commonly are associated with recreation, summer camps for children can be seen as educational arenas that both supplement and challenge school education. Summer camps provide education in a broad sense of bildung. The article aims at describing what is experienced in summer camps and proposes various theoretical frames for these bildung processes. The main focus is on summer camps in Russia, and we interviewed Russian informants who participated in summer camps. The findings were that learning in the camps tends to be non-instrumental, allowing room for play and experimentation for both pupils and teachers. Social learning is marked by collective elements such as camp rituals and spontaneous solidarity, both forming an individual personality. Outdoor activities are important because they connect children to nature and develop a sense of place marked by biophilia. Furthermore, nature’s materiality creates a sense of being in the world, which means developing a sense of multiple relational settings, spanning from the materialities of geography, place, and objects to experiencing new social settings in the form of solidarity, ritual, and friendship.
Needs and Performance Analysis for Changes in Higher Education and Implementation of Artificial Intelligence, Machine Learning, and Extended Reality
Authors: Ilić Milena P. , Păun Dan , Popović Šević Nevenka , Hadžić Aleksandra , Jianu Anca
Published: September 2021

Higher education in the Republic of Serbia needs to be reformed. This paper presents a performance analysis of the changes that the authors assume are mandatory, presenting the research problem this article addresses. Cabinet research, performed by analyzing the theoretical building blocks of available knowledge and experience, is underway. Articles and studies from various publications, such as academic journals and institutes, were used as sources. In addition, academic articles and papers and studies about artificial intelligence, machine learning, and extended reality were also consulted. The authors consider that these technologies could be of great assistance in developing a new higher education strategy. Further, this research is exploratory given that information from the 100 Serbian students from selected higher education institutions was used to better understand if these technologies are welcomed by students. Based on SmartPls software, the research analysis proved that artificial intelligence (AI) and machine learning (ML) are appropriate technologies implemented in higher education institutions (HEI) to develop skills among students, a collaborative learning environment, and an accessible research environment. Additionally, extended reality (XR) facilitates increased motivation, engagement, and learning-by-doing activities between students, offering a realistic environment for learning.
Teachers Working in Special Schools in Scotland Acting with Practical Wisdom: Supporting Children with Additional Needs in COVID-19 Lockdown
Authors: Mercieca Daniela , Mercieca Duncan P. , Ward Kumara
Published: September 2021

The COVID-19 lockdown has substantially disrupted the established facets of teacher engagement with their students, and, given the significance of this multidimensional interaction, it brings into question what we know as teachers’ identity. The lockdown has offered a dilemmatic context where the processes of teaching and learning and being(s) a teacher are being re-visited and re-negotiated. This paper looks specifically at the perceptions of two teachers of their lockdown experience working within a special education context in Scotland, supporting children with disabilities and/or learning difficulties while at home. The question that this paper addresses is: what is the understanding of these two teachers of their role in a specialised educational context while in COVID-19 lockdown? This paper uses ‘practical wisdom’ (also known as phronêsis) as its theoretical basis, where the focus is on teachers’ judgements at precisely those moments where guidelines and procedures are unclear, and the criteria open to multiple interpretations. The COVID-19 pandemic certainly provided this context. Richard Smith’s interpretation of phronêsis as ‘attentiveness’ are central to this paper. In-depth interviews carried out with teachers are analysed through this theoretical framework and two themes are discussed.
University Students with Intellectual Disabilities: Empowerment through Voice
Authors: Kubiak John , Aston Des , Devitt Marie , Ringwood Barbara
Published: September 2021

People with disabilities have been among the most marginalised groups both within society and within post-secondary/higher education. Over the last two decades, an increasing number of inclusive educational programmes have come into existence both nationally and internationally for this group of learners. The Trinity Centre for People with Intellectual Disabilities (TCPID), School of Education, Trinity College Dublin, offers students with intellectual disabilities a two-year programme entitled Arts, Science and Inclusive Applied Practice (ASIAP). This paper presents a selection of voices from ASIAP students which highlights their experiences of becoming both co-researchers and second language learners. These studies present a variety of ways in which power relationships are negotiated between faculty and students through utilising creative and inclusive approaches to the research process.
Mentoring and Coaching as a Learning Technique in Higher Education: The Impact of Learning Context on Student Engagement in Online Learning
Authors: Gamage Kelum A. A. , Perera D. A. Sharmini , Wijewardena M. A. Dilini N.
Published: September 2021

Coaching and mentoring has been regarded as one of the key learning techniques in the modern learning environment in the recent past. With the swift shift in the higher education sector to a more digitally driven learning environment, limited research has evaluated the impact of coaching and mentoring on student engagement in online learning. This study aimed to evaluate the impact of coaching and mentoring on enhancing student engagement in the higher education sector. The study applied a combination of quantitative and qualitative methods of data collection, where the primary data were collected from 120 respondents via a questionnaire and 20 in-depth interviews, covering undergraduates through a simple random sampling technique. The data analysis showed that the mentor’s ability to facilitate learning and encourage mentees to be focused on their goals were the most significant factors that affected student engagement in online learning. In total, 43% of the respondents extremely agreed that they are willing to recommend their colleagues to receive the service of a mentor to help them reach their optimum potential in an online learning environment. The findings of the study recommend that the higher educational institutes should administer a sound mentoring process that meets the ethical backgrounds to consistently support the continuous improvement of the students in an online learning environment to enhance their engagement in learning activities.
Compact Galvanically Isolated Architectures for Low-Power DC-DC Converters with Data Transmission
Authors: Ragonese Egidio , Parisi Alessandro , Spina Nunzio , Palmisano Giuseppe
Published: September 2021

This paper reviews state-of-the-art architectures for galvanically isolated DC-DC converters with data transmission for low-power applications. Such applications do not have stringent requirements, in terms of power efficiency, but ask for very compact, highly integrated implementations. To this aim, architecture simplicity is crucial, especially when data transmission and/or output power regulation are required. Since the bottleneck of galvanically isolated systems is the isolation device (i.e., typically a stacked thick oxide or polyimide transformer), the reduction of the number of isolated links, while preserving both power and data functionalities, is the more effective strategy to increase the level of integration, reduce the form factor, and have a lower cost per channel. Specifically, this review compares the pros and cons of different architectures that address this challenge differently from traditional solutions.
Carbon Emissions Reduction and Corporate Financial Performance: The Influence of Country-Level Characteristics
Authors: van Emous Robin , Krušinskas Rytis , Westerman Wim
Published: September 2021

Using a cross-country dataset covering 9265 observations on 1785 firms representing 53 countries over the period 2004–2019, this study investigates the relation between carbon emissions reduction and corporate financial performance (CFP). We perform OLS regressions with fixed effects. We found that carbon emissions reduction increases the return on assets, the return on equity, and the return on sales, whereas it has no effect on the Tobin’s Q and the current ratio. The positive relationship with the return on assets is stronger for firms with a higher responsibility score. We study country characteristics by modeling GDP growth, overall emissions within a country, and the presence of carbon emissions legislation. Our results indicate that the overall carbon emissions of a country and the presence of carbon emissions legislation are related to both corporate carbon emissions reduction and CFP. Moderating effects of the country’s overall emissions and the presence of carbon emissions legislation do not affect the relationship between carbon emissions reduction and CFP. Despite the further understanding gained, the issue of whether it “pays to be green” can still not be resolved well.
Is It Possible to Obtain Benefits by Reducing the Contribution of the Digital Signal Processing Techniques to the Control of the Active Power Filter?
Authors: Szromba Andrzej
Published: September 2021

This paper presents a simple yet efficient control method for active power filters that can be used to improve power quality. Applying this method can open the way towards limiting the hardware and computational expenditure, which are needed for control of the active filter, while maintaining its required performance. The method is based on the indirect approach of obtaining reference signals combined with the closed-loop current control technique. Monitoring of changes of energy stored in reactance elements of the active filter is the base for obtaining reference signals for compensation. The active filter can perform classical compensation and, additionally, can perform some extra functionality for managing of active power in the system. In particular, it can stabilize the supplying source power, enable energy exchange between loads connected on DC and AC sides of the active filter, and—in a case of generating loads—enable their energy storage and redistribution amongst consuming loads. The presented method can be useful for voltage-source as current-source inverter based active filters, and for DC systems as well as for AC single- or three-phase ones.
Between Poverty and Energy Satisfaction in Polish Households Run by People Aged 60 and Older
Authors: Piekut Marlena
Published: September 2021

The household sector contributes significantly to a country’s energy consumption. Energy carrier expenses are the highest expenditures in Polish household budgets. Households run by individuals aged 60 and older are heavily burdened with energy expenditures. The scientific aim of the research is to present and assess housing conditions, with particular emphasis on energy poverty in households run by individuals aged 60 and older. Multivariate statistical analyses were used to conduct the research objectives (cluster methods, variance methods, regression methods). This paper identifies a new index—one that has been applied to the situation in Poland. Households that consist of elderly people are strongly diversified in terms of housing conditions (including energy conditions). There are concerns that some households are not able to access energy services that are required to satisfy basic human needs, particularly individuals with low levels of education, living on social benefits, with low disposable incomes, or living in the countryside. Households represented by men aged 60 and older have better energy supply than households run by women. The older the individual representing the household, the greater the likelihood that his/her energy service needs are not met.
Understanding the Influence of Wake Cavitation on the Dynamic Response of Hydraulic Profiles under Lock-In Conditions
Authors: Roig Rafel , Chen Jian , de la Torre Oscar , Escaler Xavier
Published: September 2021

To accelerate the integration of fluctuating renewable energy technologies in the power systems, it is necessary to increase the flexibility of hydropower by operating turbines at off-design conditions. Unfortunately, this strategy causes deleterious flow phenomena such as von Kármán’s vortices at the wake of the vanes and/or blades. When their shedding frequency lies in the vicinity of a structure’s natural frequency, lock-in occurs and vibration amplitudes increase significantly. Moreover, if cavitation occurs at the centers of these vortices, the structure’s dynamic response will be modified. In order to understand this interaction and to avoid its negative consequences, the vibration behavior of a NACA 0009 hydrofoil under a torsional lock-in condition was numerically simulated for cavitation-free and cavitating-flow conditions. The results showed that the presence of vortex cavitation modified the formation and growth process of shed von Kármán vortices in the near-wake region which, in turn, caused an increase of the work performed by the hydrofoil deformation on the surrounding flow and a sharp decrease of the maximum vibration amplitude under resonance conditions.
Sustainability and Society: Do Environmental, Social, and Governance Factors Matter for Foreign Direct Investment?
Authors: Chipalkatti Niranjan , Le Quan Vu , Rishi Meenakshi
Published: September 2021

Sustainable investing allocates investments based on environmental, social and governance factors (ESG). The societal value of sustainable investment is becoming progressively relevant as investors are increasingly recognizing the importance of investing in companies that seek to combat climate change, environmental destruction, while promoting corporate responsibility. Environmental policy and sustainable growth initiatives at a country-level are also being influenced by the UN’s Sustainable Development Goals (SDGs). Situated within the current trend of declining foreign direct investment flows (FDI), our study examines the role of ESG factors in attracting FDI and enabling progress toward SDGs. We econometrically examine the linkages between ESG and FDI inflows for a sample of 161 counties. We also focus on low- and middle-income emerging economies and low- and middle-income commodity exporters as these countries face unique challenges of mobilizing financing to achieve SDGs and generating sustainable economic growth. Results suggest that FDI inflows to the full sample of countries are positively attracted by good governance in a destination country. We observe that good scores on HDI deters FDI, that higher FDI flows are associated with higher levels of carbon emissions in the case of emerging markets. Sustainability reporting attracts FDI to commodity exporting countries. The study provides possibilities for future research in a post-pandemic future.
Design and Modelling of 3D Bionic Cathode Flow Field for Proton Exchange Membrane Fuel Cell
Authors: Xuan Lingfeng , Wang Yancheng , Mei Deqing , Lan Jingwei
Published: September 2021

Proton exchange membrane fuel cells (PEMFCs) have been utilized as a promising power source for new energy vehicles. Their performances are greatly affected by the structural design of the flow field in the bipolar plate. In this paper, we present a novel three-dimensional (3D) bionic cathode flow field, inspired by the small intestinal villi. The structural design and working principle of the 3D bionic flow field units are first described. A 3D numerical model is developed to study the mass transfer and distribution of the reactants and products, as well as the polarization performances of the PEMFC with the 3D bionic cathode flow field. The simulation results indicate that the proposed 3D bionic flow field can significantly improve the reaction gas supply from the flow field to porous electrodes, and thus would be beneficial for the removal of liquid water in the cathode. The mass transfer of gas in the PEMFC can be enhanced due to the increasing contact areas between the gas diffusion layer (GDL) and the cathode flow field, and the distribution of currents in the membrane would be more uniform. The obtained results demonstrated the feasibility of using the 3D bionic flow field for the development of highly efficient PEMFCs with high power density.