bluuebunny/crossref_metadata_2025 huggingface dataset:
Lifetime Prevalence of Victimization and Perpetration as Related to Men’s Health: Clinical Insights
Authors: Leiding Delia , Kaiser Franziska , Hüpen Philippa , Kirchhart Ramona , Puiu Andrei Alexandru , Steffens Marion , Bergs Rene , Habel Ute
Published: March 2022

Violence is a known risk factor for health problems. In this epidemiological study across 5,385 male patients, we investigate the prevalence of perpetrated violence, exposure to violence, their overlap and the relationship between violence, mental, and psychosomatic health, as well as adverse health behaviors, such as self-harming behavior and the consumption of drugs. Participants completed an anonymous questionnaire addressing violence experience (i.e., both expose and perpetration), age of victimization/perpetration, frequency, and perceived severity of violence exposure. We considered physical, psychological as well as sexual violence. Information on health status and adverse health behaviors complemented the data. Results showed that 48.4% of the sample reported having experienced violence (perpetration, victimization, or both). The victim-perpetrator overlap formed the largest group, in which the incidence of having experienced multiple types of violence was significantly higher compared to victims and perpetrators. The age-crime curve flattened more slowly with increasing age in this group. Although the perceived severity of exposure to violence is lower in the overlap group, its health status and adverse health behaviors were worse. Interventions should focus on this group since they constitute a burden for the healthcare system.
Tell Me Where You Live… How the Perceived Entitativity of Neighborhoods Determines the Formation of Impressions About Their Residents
Authors: Bernardo Fátima , Palma-Oliveira José Manuel
Published: March 2022

The studies presented here apply the concept of entitativity in order to understand how belonging to a particular geographical area – neighborhood - can determine the way others organize information and form impressions about area’s residents. In order to achieve this objective, three studies were carried out. The first study aims to verify if a neighborhood varies in terms of perceived entitativity, and identify the physical and social characteristics of the neighborhoods that are more strongly associated with the perception of entitativity. The Study 2 and 3 used an experimental paradigm to explore how people’s perceptions of neighborhoods’ entitativity influenced their impressions of residents. To activate stereotypes, Study 2 used the name of real neighborhoods, and Study 3 employed only a set of pictures of unknown neighborhoods. The results show that the neighborhoods vary significantly with the regard to the perception of entitativity, and a set of physical attributes of place were strongly related with entitativity. The results showed that, independent of stimuli, the neighborhoods perceived as highly entitative, the supposed residents were subject to more extreme and quicker trait judgments, supported by greater confidence on the part of perceivers. Study 3 also reported that in highly entitative neighborhoods, the perceivers transferred more traits from the group to individual members. These results provide strong evidence that physical structure of neighborhoods imply different entitatity judgments that influences the way in which residents are perceived.
Do Age and Linguistic Status Alter the Effect of Sound Source Diffuseness on Speech Recognition in Noise?
Authors: Avivi-Reich Meital , Sran Rupinder Kaur , Schneider Bruce A.
Published: March 2022

One aspect of auditory scenes that has received very little attention is the level of diffuseness of sound sources. This aspect has increasing importance due to growing use of amplification systems. When an auditory stimulus is amplified and presented over multiple, spatially-separated loudspeakers, the signal’s timbre is altered due to comb filtering. In a previous study we examined how increasing the diffuseness of the sound sources might affect listeners’ ability to recognize speech presented in different types of background noise. Listeners performed similarly when both the target and the masker were presented via a similar number of loudspeakers. However, performance improved when the target was presented using a single speaker (compact) and the masker from three spatially separate speakers (diffuse) but worsened when the target was diffuse, and the masker was compact. In the current study, we extended our research to examine whether the effects of timbre changes with age and linguistic experience. Twenty-four older adults whose first language was English (Old-EFLs) and 24 younger adults whose second language was English (Young-ESLs) were asked to repeat non-sense sentences masked by either Noise, Babble, or Speech and their results were compared with those of the Young-EFLs previously tested. Participants were divided into two experimental groups: (1) A Compact-Target group where the target sentences were presented over a single loudspeaker, while the masker was either presented over three loudspeakers or over a single loudspeaker; (2) A Diffuse-Target group, where the target sentences were diffuse while the masker was either compact or diffuse. The results indicate that the Target Timbre has a negligible effect on thresholds when the timbre of the target matches the timbre of the masker in all three groups. When there is a timbre contrast between target and masker, thresholds are significantly lower when the target is compact than when it is diffuse for all three listening groups in a Noise background. However, while this difference is maintained for the Young and Old-EFLs when the masker is Babble or Speech, speech reception thresholds in the Young-ESL group tend to be equivalent for all four combinations of target and masker timbre.
Predicting the Intention to Pursue Certified Professional Accountancy Qualification Among the Accounting Students
Authors: Chi Tiw Kai , Sin Yi Thai , Al Mamun Abdullah , Hayat Naeem , Salamah Anas A. , Yang Qing
Published: March 2022

The global progress empowers the development of new business and expansion of existing business. The availability of sufficient accounting professional are necessary to manage and document the business activities. However, youth are less inclined to purse accounting as profession to keep the progress of global and local economic development. The current study aimed to explore the formation of the intention to pursue Certified Professional Accountancy Qualification (CPAQ) with factor of capabilities, career opportunities, job security with respect to the extended theory of planned behavior (TPB), i.e., attitude, subjective norms and perceived behavioral control. The study adopted a cross-sectional design and collected quantitative data from a total of 339 accounting students from Malaysia using an online survey. The finding revealed that capabilities and career opportunities influenced the students’ intention to pursue CPAQ. Meanwhile, perceived behavioral control had significantly affect the students’ decision to pursue CPAQ, which is in line with the TPB. The study concentrated on the importance of these factors in influencing the students’ intention and decision to pursue CPAQ. The study offered vital implications for accounting educators and educational institutions to promote the accounting profession as choice and students engage in pursuing CPAQ. The Malaysian government should encourage and support accounting students financially for pursuing CPAQ by providing job security and enhancing subjective norms that may enable these students to complete the required professional qualifications. The study’s limitations and future research opportunities are documented at the end of this article.
Spatial Distribution and Factors Associated With Risky Health Behavior Among Adult Males Aged 15–59 Years in Ethiopia: Generalized Structural Equation Modeling
Authors: Kebede Sewnet Adem , Weldesenbet Adisu Birhanu , Tusa Biruk Shalmeno
Published: March 2022

Background

Alcohol drinking and tobacco smoking are the largest preventable causes of death and important risk factors for a number of non-communicable diseases and cause premature death and many socioeconomic consequences. Therefore, the present study is aimed to assess the spatial distribution of risky health behavior and its associated factors among adult males in Ethiopia.

Methods

All men (12,688) within the age range of 15–59 years were included in the final analysis. The distribution of risky health behavior across the country was observed by using ArcGIS software. In SaTScan software, the Bernoulli model was fitted by Kulldorff methods to identify the purely spatial clusters of risky health behavior. Generalized Structural Equation Model (GSEM) was used to determine factors associated with risky health behavior (regular alcohol drinking and tobacco smoking).

Results

Risky health behavior had spatial variation across the country. The primary clusters were located in Tigray, Amhara, and north-eastern Benishangul national regional states. Spatial scan statistics identified 118 primary clusters [Log-Likelihood ratio (LLR) = 524.8, p < 0.001]. Residence, frequency of listening to a radio, occupation, and frequency of watching television were significantly associated with drinking alcohol, whereas wealth index was associated with tobacco smoking. Age, region, educational status, marital status, and religion had association with both domains of risky health behavior.

Conclusion

Risky health behavior had spatial variation across the country. Bans on advertising and promotion of alcohol and tobacco on national press media should be strengthened. Aggressive health education efforts should be directed toward this high-risk population (Tigray, Amhara, and north-eastern Benishangul regional states). Improving risky health behavior is an important approach to reducing health disparities and promoting a more cost-effective utilization of scarce resources in the public health sector.
First Application of Fecal Microbiota Transplantation in Adult Asperger Syndrome With Digestive Symptoms—A Case Report
Authors: Huang Hong-Li , Xu Hao-Ming , Liu Yan-Di , Shou Di-Wen , Chen Hui-Ting , Nie Yu-Qiang , Li Yong-Qiang , Zhou Yong-Jian
Published: March 2022

Asperger syndrome (AS) is a chronic neurodevelopmental disorder. Although all of the clinically diagnosed cases display normal intelligence and speech functions, barriers in social interaction and communication seriously affect mental health and psychological function. In addition to traditional psychological/behavioral training and symptomatic medication, in-depth studies of intestinal microbiota and mental health have indicated that probiotics (e.g., Lactobacillus rhamnosus) can effectively reduce the occurrence of AS. Fecal microbiota transplantation (FMT) is a type of biological therapy that involves the transplant of intestinal microbiota from healthy donors into the patient's gastrointestinal tract to improve the gut microenvironment. In this case report, we describe the first case of adult AS treated with FMT. The patient suffered from diarrhea-predominant irritable bowel syndrome for 6 years with symptoms of diarrhea and abdominal pain. After three rounds of FMT, the diarrhea and abdominal pain were significantly improved. Moreover, the symptoms of AS were also significantly ameliorated. We found that FMT changed the structure of the intestinal microbiota as well as the patient's serum metabolites, and these changes were consistent with the patient's symptoms. The metabolites may affect signaling pathways, as revealed by Kyoto Encyclopedia of Genes and Genomes enrichment analysis. The changes in microbial metabolites following FMT may affect other regions (e.g., the nervous system) via the circulatory system, such that the bacteria-gut-blood-brain axis may be the means through which FMT mitigates AS.
Diagnostic Stability and Phenotypic Differences Among School-Age Children Diagnosed With ASD Before Age 2
Authors: Landa Rebecca J. , Reetzke Rachel , Holingue Calliope B. , Herman Dana , Hess Christine Reiner
Published: March 2022

Given the importance of early detection, it is critical to understand the non-linearity in manifestation of ASD before age 24 months, when ASD symptoms are beginning to consolidate, through the age of 36 months when stability of ASD diagnosis is reportedly high into school-age when increased demands may challenge previously successful compensatory processes and permit first ASD detection. We employed a prospective, longitudinal design focused on children with an older sibling with ASD (n = 210) who received diagnostic evaluations at mean ages of 15.4 months (Time 1), 36.6 months (Time 2), and 5.7 years (Time 3) to examine: (1) diagnostic stability, (2) developmental trajectories associated with different patterns of ASD vs. non-ASD classifications, and (3) predictors of classification group over time. Clinical best estimate (CBE) diagnosis of ASD or non-ASD was made at each time point. Linear mixed-effects models were implemented to examine differences in developmental trajectories of stable and dynamic diagnostic groups. Multinomial logistic regression analyses were used to examine predictors of the likelihood of belonging to each CBE diagnostic classification group. Results revealed that sensitivity and stability of an ASD diagnosis significantly increased from Time 1 (sensitivity: 52%; stability: 63%) to Time 2 (sensitivity: 86%; stability: 68%). Different developmental trajectories of autism symptom severity and non-verbal and verbal IQ were observed across groups, with differences first observed at Time 1 and becoming more pronounced through Time 3. Presence of restricted and repetitive behaviors as well as limitations in initiation of joint attention and expressive language skills differentially predicted the likelihood of belonging to the different CBE diagnostic classification groups. Results suggest that ASD symptoms may emerge or attenuate over time, with some children meeting diagnosis at follow-up, and other children no longer meeting diagnostic criteria. From a systems perspective, diagnostic non-linearity may be viewed as a dynamic developmental process, where emergent properties arising from various biological, genetic, and experiential factors interact, culminating in phenotypic phenomena that change over time. Clinical implications include extending universal ASD and social communication screening into school-age, supporting families' understanding of diagnostic shifts, and ensuring unbiased diagnostic decision-making when following children with ASD.
DeepClaw 2.0: A Data Collection Platform for Learning Human Manipulation
Authors: Wang Haokun , Liu Xiaobo , Qiu Nuofan , Guo Ning , Wan Fang , Song Chaoyang
Published: March 2022

Besides direct interaction, human hands are also skilled at using tools to manipulate objects for typical life and work tasks. This paper proposes DeepClaw 2.0 as a low-cost, open-sourced data collection platform for learning human manipulation. We use an RGB-D camera to visually track the motion and deformation of a pair of soft finger networks on a modified kitchen tong operated by human teachers. These fingers can be easily integrated with robotic grippers to bridge the structural mismatch between humans and robots during learning. The deformation of soft finger networks, which reveals tactile information in contact-rich manipulation, is captured passively. We collected a comprehensive sample dataset involving five human demonstrators in ten manipulation tasks with five trials per task. As a low-cost, open-sourced platform, we also developed an intuitive interface that converts the raw sensor data into state-action data for imitation learning problems. For learning-by-demonstration problems, we further demonstrated our dataset’s potential by using real robotic hardware to collect joint actuation data or using a simulated environment when limited access to the hardware.
A Systematic Scoping Review of Human-Dog Interactions in Virtual and Augmented Reality: The Use of Virtual Dog Models and Immersive Equipment
Authors: Oxley James Andrew , Santa Kristof , Meyer Georg , Westgarth Carri
Published: March 2022

Virtual reality is beneficial from a research and education perspective as it allows the assessment of participants in situations that would otherwise be ethically and practically difficult or impossible to study in the real world. This is especially the case where the assessment of human behaviour in the presence of stimuli (e.g. an aggressive dog) is being measured which could potentially constitute a risk in a real-world environment (e.g. a dog bite). Given that the dog is the most popular companion animal species, to date there is limited research that identifies and reviews the use of virtual and augmented reality directly relating to human-dog interactions. Furthermore, there also appears to be no review of the equipment and dog model specifications, such as dog breed and behaviours, which are currently used in these studies. As a result, this systematic scoping review searched ten databases to assess the current use and specifications of dog models which directly focused on human-dog interactions. Ten articles were identified. Six related to assessment or treatment of dog fear/phobia (cynophobia), three included multiple animal phobias, including dogs, and one article investigated the human and virtual dog interactions whilst walking. Six articles used a single breed (German Shepherd, Beagle, Doberman, and Rottweiler). Both the breed and behaviours displayed lacked justification and were often not evidence based. Specific measurements of model quality (e.g., polygons/vertices) were reported in only two articles which may affect repeatability and make comparisons between studies difficult. The virtual reality equipment (e.g. CAVE, head mounted display) and navigation methods (e.g. joystick, mouse, room scale walking) used varied between studies. In conclusion, there is a need for the accurate development and representation, including appearance and behaviours, of dog models in virtual and augmented reality. This is of high importance especially as most of the research covered in this review was conducted with the aim to treat the fear or phobia of dogs.
Multiple Model Evaluation of the Masseteric-to-Facial Nerve Transfer for Reanimation of the Paralyzed Face and Quick Prognostic Prediction
Authors: Li Tengfei , Liu Yanhui , Zhang Shuxin , Yang Wanchun , Zuo Mingrong , Liu Xuesong
Published: March 2022

Facial paralysis is negatively associated with functional, aesthetic, and psychosocial consequences. The masseteric-to-facial nerve transfer (MFNT) has many advantages in facial reanimation. The aim is to evaluate the effectiveness of our MFNT technique and define the potential factors predictive of outcome. The authors conducted a retrospective review of 20 consecutive patients who underwent MFNT using the temporofacial trunk of facial nerve. Videotapes and images were documented and evaluated according to Facial Nerve Grading Scale 2.0 (FNGS2.0) and Sunnybrook Facial Grading System (FGS). The quality-of-life was obtained using the Facial Clinimetric Evaluation (FaCE) Scale. Moreover, Facial Asymmetry Index (FAI), quantitative measurement of the width of palpebral fissure, deviation of the philtrum, and angles or excursions of the oral commissure were applied to explore the effect of the transfer metrically. Multivariable logistic regression models and Cox regression were prepared to predict the effect of MFNT by preoperative clinical features. The patients showed favorable outcomes graded by FNGS2.0, and experienced significantly improved scores in static and dynamic symmetry with slightly elevated scores in synkinesis evaluated by the Sunnybrook FGS. The score of FaCE Scale increased in all domains after reanimation. The quantitative indices indicated the symmetry restoration of the middle and lower face after MFNT. Regression analysis revealed that younger patients with severe facial paralysis are preferable to receive MFNT early for faster and better recovery, especially for traumatic causes. The findings demonstrate that MFNT is an effective technique for facial reanimation, and case screening based on clinical characteristics could be useful for surgical recommendation.
Nondestructive Identification of Litchi Downy Blight at Different Stages Based on Spectroscopy Analysis
Authors: Li Jun , Wu Junpeng , Lin Jiaquan , Li Can , Lu Huazhong , Lin Caixia
Published: March 2022

Litchi downy blight caused by Peronophythora litchii is the most serious disease in litchi production, storage and transportation. Existing disease identification technology has difficulty identifying litchi downy blight sufficiently early, resulting in economic losses. Thus, the use of diffuse reflectance spectroscopy to identify litchi downy blight at different stages of disease, particularly to achieve the early identification of downy blight, is very important. The diffuse reflectance spectral data of litchi fruits inoculated with P. litchii were collected in the wavelength range of 350–1350 nm. According to the duration of inoculation and expert evaluation, they were divided into four categories: healthy, latent, mild and severe. First, the SG smoothing method and derivation method were used to denoise the spectral curves. Then, the wavelength screening methods competitive adaptive reweighted sampling (CARS) and successive projections algorithm (SPA) were compared to verify that the SPA method was more effective. Eleven characteristic wavelengths were selected, accounting for only 1.1% of the original data. Finally, the characteristic wavelengths were tested by six different classification models, and their accuracy was calculated. Among them, the ANN model performed best, with an accuracy of 90.7%. The results showed that diffuse reflectance spectroscopic technology has potential for identifying litchi downy blight at different stages, providing technical support for the subsequent development of related automatic detection devices.
Better Droplet Deposition and Internode Shortening Effects of Plant Growth Regulator EDAH on Maize Applied by Small Unmanned Aerial Vehicle Than Electric Knapsack Sprayer
Authors: Wang Zhao , Hussain Mujahid , Huang Guanmin , Yin Jiaming , Guo Yuling , Mo You , Duan Liusheng , Li Zhaohu , Tan Weiming
Published: March 2022

Maize (Zea mays L.) lodging is an important factor limiting its yield increase worldwide. EDAH (containing 27% ethephon and 3% DA-6) is commonly used to decrease lodging. There is an urgent need to select efficient application methods of agrochemical for better spray deposition. In our research, an unmanned aerial vehicle (UAV) (15 L ha−1 and 30 L ha−1) with EDAH dosages of 72 and 90 g a.i. ha−1, and electric knapsack sprayers (EKS) (450 L ha−1) with dosages of 90 g a.i. ha−1 were used to compare the droplet deposition distribution, uniformity and maize growth. According to our research, EDAH applied by UAV had a higher droplet deposition rate than EKS; EKS had a higher droplet coverage rate, deposition density, droplet distribution uniformity. At the same dosage of EDAH, the UAV had a better effect on controlling maize growth than EKS, and almost equal effects were detected when the dosage applied by the UAVs was decreased by 20%. Considering the lodging occurrence and yield, we recommend that the dosage of EDAH applied by UAVs should be 72 g a.i. ha−1 when there is weak lodging and 90 g a.i. ha−1 when there is heavy lodging, with a spray volume of 15 L ha−1.
Preliminary Findings of Polypropylene Carbonate (PPC) Plastic Film Mulching Effects on the Soil Microbial Community
Authors: Liang Jing , Zhang Jiafan , Yao Zongmu , Luo Shouyang , Tian Lei , Tian Chunjie , Sun Yu
Published: March 2022

The farmland residual film pollution caused by traditional PE film has an adverse impact on crops and the environment. Polypropylene carbonate (PPC) film is a fully biodegradable film that can alleviate “white pollution”. In this study, the soil physicochemical properties and the composition and function of the soil community of FM (PPC film mulching) and CK (no film) treatments were determined to explore the effect of PPC film mulching on soil and the soil microbial community. Furthermore, the microorganisms at different time periods during the degradation of PPC mulch film were also analyzed. The results showed that film mulching increased soil pH but decreased the contents of EC and SOC, and there was no significant difference in the contents of AP and AK. The relative abundance of the phyla Acidobacteria was increased with film mulching, and the relative abundance of the genera MB_A2_108 also increased in the film mulched soil. Among the soil physicochemical properties, pH and SOC were the most important factors leading to changes in the composition of the bacterial and fungal communities. PPC film mulching had no significant effect on soil microbial community abundance and diversity. In addition, Pseudomonas, Flavobacterium, and Rhizobacter were dominant in the degradation of PPC film. Our research results provide a scientific theoretical basis for soil safety and the large-scale use of PPC biodegradable mulching films and a research foundation for the degradation of PPC plastics.
ALA_PDT Promotes Ferroptosis-Like Death of Mycobacterium abscessus and Antibiotic Sterilization via Oxidative Stress
Authors: Wang Xiaoyu , Wan Meiyin , Zhang Lei , Dai Yongdong , Hai Yang , Yue Chenda , Xu Junqi , Ding Yadan , Wang Mei , Xie Jianping , Lei Xia , Zhong Julia-Li
Published: March 2022

Mycobacterium abscessus is one of the common clinical non-tuberculous mycobacteria (NTM) that can cause severe skin infection. 5-Aminolevulinic acid photodynamic therapy (ALA_PDT) is an emerging effective antimicrobial treatment. To explore whether ALA_PDT can be used to treat M. abscessus infections, we conducted a series of experiments in vitro. We found that ALA_PDT can kill M. abscesses. Mechanistically, we found that ALA_PDT promoted ferroptosis-like death of M. abscesses, and the ROS scavenger N-Acetyl-L-cysteine (NAC) and ferroptosis inhibitor Ferrostatin-1 (Fer-1) can mitigate the ALA_PDT-mediated sterilization. Furthermore, ALA_PDT significantly up-regulated the transcription of heme oxygenase MAB_4773, increased the intracellular Fe2+ concentration and altered the transcription of M. abscessus iron metabolism genes. ALA_PDT disrupted the integrity of the cell membrane and enhanced the permeability of the cell membrane, as evidenced by the boosted sterilization effect of antibiotics. In summary, ALA_PDT can kill M. abscesses via promoting the ferroptosis-like death and antibiotic sterilization through oxidative stress by changing iron metabolism. The study provided new mechanistic insights into the clinical efficacy of ALA_PDT against M. abscessus.
Sex-Dependent Protective Effect of Combined Application of Solubilized Ubiquinol and Selenium on Monocrotaline-Induced Pulmonary Hypertension in Wistar Rats
Authors: Kuropatkina Tatyana , Pavlova Olga , Gulyaev Mikhail , Pirogov Yury , Khutorova Anastasiya , Stvolinsky Sergey , Medvedeva Natalia , Medvedev Oleg
Published: March 2022

Ubiquinol exhibits anti-inflammatory and antioxidant properties. Selenium is a part of a number of antioxidant enzymes. The monocrotaline inducible model of pulmonary hypertension used in this study includes pathological links that may act as an application for the use of ubiquinol with high bioavailability and selenium metabolic products. On day 1, male and female rats were subcutaneously injected with a water-alcohol solution of monocrotaline or only water-alcohol solution. On days 7 and 14, some animals were intravenously injected with either ubiquinol’s vehicle or solubilized ubiquinol, or orally with selenium powder daily, starting from day 7, or received both ubiquinol + selenium. Magnetic resonance imaging of the lungs was performed on day 20. Hemodynamic parameters and morphometry were measured on day 22. An increased right ventricle systolic pressure in relation to control was demonstrated in all groups of animals of both sexes, except the group of males receiving the combination of ubiquinol + selenium. The relative mass of the right ventricle did not differ from the control in all groups of males and females receiving either ubiquinol alone or the combination. Magnetic resonance imaging revealed impaired perfusion in almost all animals examined, but pulmonary fibrosis developed in only half of the animals in the ubiquinol group. Intravenous administration of ubiquinol has a protective effect on monocrotaline-induced pulmonary hypertension development resulting in reduced right ventricle hypertrophy, and lung mass. Ubiquinol + selenium administration resulted in a less severe increase in the right ventricle systolic pressure in male rats but not in females 3 weeks after the start of the experiment. This sex-dependent effect was not observed in the influence of ubiquinol alone.
Three-Dimensional Modeling of the Xichang Crust in Sichuan, China by Machine Learning
Authors: Gong Li-Wen , Zhang Huai , Chen Shi , Chen Li-Juan
Published: March 2022

Seismicity and distribution of earthquakes can provide active fault structural information on the crust at a regional scale. The morphology of faults can be derived from the epicentral distribution of micro-earthquakes. In this study, we combined both the relocated earthquake catalogue and related preliminary geophysical information for 3D modeling of the crust in the Xichang area, Sichuan province, China. The fault morphology and deep crustal structure were automatically extracted by the machine learning approach, such as the supervised classification and cluster analysis methods. This new 3D crustal model includes the seismic velocity distribution, fault planes in 3D and 3D seismicity. There are many earthquake clusters located in the folded basement and low-velocity zone. Our model revealed the topological relation between the folded basement and faults. Our work show the crustal model derived is supported by the earthquake clusters which in turn controls the morphological characteristics of the crystalline basement in this area. Our use of machine learning techniques can not only be used to predict the refined fault geometry, but also to combine the seismic velocity structure with the known geological information. This 3D crustal model can also be used for geodynamic analysis and simulation of strong motionseismic waves.
Performance of Low-Height Railway Noise Barriers with Porous Materials
Authors: Lázaro João , Pereira Matheus , Costa Pedro Alves , Godinho Luís
Published: March 2022

Rail transport is the most sustainable transportation mode, with the lowest energy consumption and carbon footprint. However, the noise induced by railway traffic in urban regions is a significant drawback and several reports point out the risks and the amount of people suffering from direct exposure to railway noise. One of the most used mitigation measures for railway noise is the implementation of noise barriers. Although they offer a significant reduction in noise levels, their height makes people feel enclosed. Therefore, in the case of railway infrastructure, the solution to the problem may lie in the use of barriers with a lower height placed close to the railway track. As the noise-forming mechanisms are mainly located at the track level, placing the barrier in a position close to the track allows mitigating rail noise without causing the problems identified above for the population in the vicinity. The purpose of this paper is to illustrate the development of a barrier solution to be used in a railway context through numerical modelling with the Boundary Element Method (BEM). The solutions developed were placed close to the track and have a low height. The geometry was defined so as to direct the energy back to the track to take advantage of the acoustic properties of the ballast. The addition of a porous granular material on the inner face of the barrier allows the control of reflections between the vehicle body and the barrier, increasing its acoustic efficiency. Finally, considering the most efficient solution, the insertion loss in a network of receivers located 10 m away from the track is analysed in order to study the noise reduction levels in a place where human receivers are usually located.
Influence of 2% Chlorhexidine on the Bond Strength of Three Adhesive Systems on Primary Molars: An In Vitro Study
Authors: Velayos-Galán Laura , Molinero-Mourelle Pedro , Sevilla Pablo , Fonseca Manrique , Mourelle-Martínez María Rosa , Vera-González Vicente
Published: March 2022

The hydrolysis of the collagen matrix by metalloproteinases (MMPs) is one of the paradigms that currently arouses most interest due to its close relationship with a decrease in bond strength (BS) and consequent restoration failure. Chlorhexidine 2% has demonstrated its ability to inhibit MMPs’ activity in the permanent dentition, improving the duration of resin–dentine, but there are few studies on deciduous dentition and its possible repercussions. Aim: To determine the influence of 2% chlorhexidine digluconate (CHX) as a dentine pretreatment on the BS of three adhesive systems on primary molars. Methods: 128 primary extracted molars were assigned to eight groups at random. BS in vitro was recorded by micropush-out test, and analyzed by two-way ANOVA. Results: BS values oscillated from 15.01 MPa to 20.41 MPa. There was no statistically relevant variation between the BS total mean of those adhesive groups that had received CHX pretreatment versus those that did not. Adper Prompt L-Pop was the self-etching adhesive with the best BS. Adper Scotchbond 1XT was the total-etch adhesive with the best BS values. Conclusions: Application of 2% chlorhexidine for 60 s as dentine pretreatment did not affect the immediate BS of several adhesive systems used in primary dentition.
The Association of Carcinoembryonic Antigen (CEA) and Air Pollutants—A Population-Based Study
Authors: Fang Yi-Jen , Lee Lukas Jyuhn-Hsiarn , Luo Kuei-Hau , Fang Po-Sheng , Yang Chen-Cheng , Chuang Hung-Yi
Published: March 2022

Air pollutants are substances in the air that have harmful effects on humans and the ecological environment. Although slight elevations in carcinoembryonic antigen (CEA) are commonly observed in apparently healthy persons, potential associations between CEA levels and chronic low-grade inflammation induced by air pollution have yet to be documented. We conducted a community-based cross-sectional study to estimate the association between short-term exposure to ambient air pollution and the CEA. A total of 9728 participants from health examinations were enrolled for the analysis and linked with their residential air pollutant data including ozone (O3), nitrogen dioxide (NO2), carbon monoxide (CO), sulphur dioxide (SO2), and particulate matter (PM10). The results showed that every increase of 1 ppm O3 significantly increased the mean differences of the CEA blood concentration by 0.005 ng/mL. Each increase of 1 ppm CO significantly reduced the mean differences of the CEA blood concentration by 0.455 ng/mL. Although smoking and alcohol drinking also increased the CEA levels, with adjustment of these confounders we identified a significant association between serum CEA in the general population and levels of the air pollutants O3 and CO. In conclusion, the serum CEA concentrations and short-term air pollutants O3 and CO exposure were found to have a significant relationship; however, its mechanism is still unclear. Moreover, long-term air pollution exposure and changes in CEA concentration still need to be further evaluated.
A Hybrid MPI/OpenMP Parallelization Scheme Based on Nested FDTD for Parametric Decay Instability
Authors: He Linglei , Chen Jing , Lu Jie , Yan Yubo , Yang Jutao , Yuan Guang , Hao Shuji , Li Qingliang
Published: March 2022

Parametric decay instability (PDI) generated in milliseconds is an important physical phenomenon in ionospheric heating. Usually, numerical simulations are used to study PDI mechanisms. They can intuitively investigate the generation and development process of PDI, which is necessary in experimental studies. When simulating the PDI phenomenon through the explicit finite-difference time-domain (FDTD), the spatial scale spans from kilometers to centimeters, and the time scale needs to meet the Courant–Friedrichs–Lewy condition. Simulating the PDI phenomenon is time-consuming and difficult due to the high spatial resolution and strict restriction on the discrete time step. Although a nested mesh technique can boost the computational efficiency, the application of a parallel strategy is imperative to further improve it. In this study, we present a hybrid Message Passing Interface (MPI)/OpenMP parallelization scheme to solve the above-mentioned problems. This scheme can achieve an adaptive calculation and automatic allocation of MPI tasks and OpenMP threads, proving its flexibility and portability. Under the EISCAT background parameters, the PDI phenomenon was simulated. The results of the wave mode conversion and intense localized turbulence were identical to those of the serial program. Furthermore, a new simulation example and the effect of the cavity depth on electrostatic waves and negative ion density cavity were investigated. By utilizing the proposed parallelization scheme, the simulation time can be reduced from 70 h for the serial program to 3.6 h.
Circulating Levels of PD-L1, TIM-3 and MMP-7 Are Promising Biomarkers to Differentiate COVID-19 Patients That Require Invasive Mechanical Ventilation
Authors: Chavez-Galan Leslie , Ruiz Andy , Martinez-Espinosa Karen , Aguilar-Duran Hiram , Torres Martha , Falfan-Valencia Ramces , Pérez-Rubio Gloria , Selman Moises , Buendia-Roldan Ivette
Published: March 2022

Background: COVID-19 is an infectious disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Many COVID-19 patients require invasive mechanical ventilation (IMV) while others, even with acute respiratory failure, do not (NIMV). Therefore, we aimed to evaluate serum levels of MMP-7 and molecules related to exhausted T-cells as potential biomarkers to differentiate between IMV and NIMV patients. Methods: 105 patients diagnosed with COVID-19 and confirmed by RT-PCR for SARS-CoV-2 were divided into two groups according to the requirement for IMV. Serum levels of sPD-L1, sPD-L2, sTIM-3, sGal-9 and sMMP-7 were quantified by ELISA and correlated with clinical data. Twelve patients were followed up after eight months to compare the levels of the biomarkers between acute disease and post-COVID-19. Results: IMV patients experienced a lower PaO2/FiO2 (p < 0.0001) and a longer hospital stay (p < 0.0001), and exhibited higher levels of sPD-L1 (p < 0.05), sTIM-3 (p < 0.01) and sMMP-7 (p < 0.0001) when compared with NIMV patients. According to a ROC analysis, sMMP-7 had the highest sensitivity (78%) and specificity (76%) with a cut point of 4.5 ng/mL, followed by sTIM-3 and sPD-L1. Eight months post-COVID-19, IMV patients displayed a significant decrease in the initially high levels of sPD-L1, sTIM-3 and sGal-9, while sPD-L2 was increased, and sMMP-7 was unchanged. Conclusion: Circulating levels of sPD-L1, sTIM-3 and sMMP-7 are potential biomarkers of disease severity to distinguish patients requiring IMV. MMP-7 could also be a marker for the persistence of lung lesions post-COVID-19.
Inhibition of STAT6 Activation by AS1517499 Inhibits Expression and Activity of PPARγ in Macrophages to Resolve Acute Inflammation in Mice
Authors: Lee Ye-Ji , Kim Kiyoon , Kim Minsuk , Ahn Young-Ho , Kang Jihee Lee
Published: March 2022

Signal transducer and activator of transcription 6 (STAT6) promotes an anti-inflammatory process by inducing the development of M2 macrophages. We investigated whether modulating STAT6 activity in macrophages using AS1517499, the specific STAT6 inhibitor, affects the restoration of homeostasis after an inflammatory insult by regulating PPARγ expression and activity. Administration of AS1517499 suppressed the enhanced STAT6 phosphorylation and nuclear translocation observed in peritoneal macrophages after zymosan injection. In addition, AS1517499 delayed resolution of acute inflammation as evidenced by enhanced secretion of pro-inflammatory cytokines, reduced secretion of anti-inflammatory cytokines in PLF and supernatants from peritoneal macrophages, and exaggerated neutrophil numbers and total protein levels in PLF. We demonstrate temporal increases in annexin A1 (AnxA1) protein and mRNA levels in peritoneal lavage fluid (PLF), peritoneal macrophages, and spleen in a murine model of zymosan-induced acute peritonitis. In vitro priming of mouse bone marrow-derived macrophages (BMDM) and peritoneal macrophages with AnxA1 induced STAT6 activation with enhanced PPARγ expression and activity. Using AS1517499, we demonstrate that inhibition of STAT6 activation delayed recovery of PPARγ expression and activity, as well as impaired efferocytosis. Taken together, these results suggest that activation of the STAT6 signaling pathway mediates PPARγ expression and activation in macrophages to resolve acute inflammation.
Nature-Inspired O-Benzyl Oxime-Based Derivatives as New Dual-Acting Agents Targeting Aldose Reductase and Oxidative Stress
Authors: Ciccone Lidia , Petrarolo Giovanni , Barsuglia Francesca , Fruchart-Gaillard Carole , Cassar Lajeunesse Evelyne , Adewumi Adeniyi T. , Soliman Mahmoud E. S. , La Motta Concettina , Orlandini Elisabetta , Nencetti Susanna
Published: March 2022

Aldose reductase (ALR2) is the enzyme in charge of developing cellular toxicity caused by diabetic hyperglycemia, which in turn leads to the generation of reactive oxygen species triggering oxidative stress. Therefore, inhibiting ALR2 while pursuing a concomitant anti-oxidant activity through dual-acting agents is now recognized as the gold standard treatment for preventing or at least delaying the progression of diabetic complications. Herein we describe a novel series of (E)-benzaldehyde O-benzyl oximes 6a–e, 7a–e, 8a–e, and 9–11 as ALR2 inhibitors endowed with anti-oxidant properties. Inspired by the natural products, the synthesized derivatives are characterized by a different polyhydroxy substitution pattern on their benzaldehyde fragment, which proved crucial for both the enzyme inhibitory activity and the anti-oxidant capacity. Derivatives (E)-2,3,4-trihydroxybenzaldehyde O-(3-methoxybenzyl) oxime (7b) and (E)-2,3,4-trihydroxybenzaldehyde O-(4-methoxybenzyl) oxime (8b) turned out to be the most effective dual-acting products, proving to combine the best ALR2 inhibitory properties with significant anti-oxidant efficacy.
The Exoproteome of Staphylococcus pasteuri Isolated from Cervical Mucus during the Estrus Phase in Water Buffalo (Bubalus bubalis)
Authors: Srinivasan Mahalingam , Muthukumar Subramanian , Rajesh Durairaj , Kumar Vinod , Rajakumar Rajamanickam , Akbarsha Mohammad Abdulkader , Gulyás Balázs , Padmanabhan Parasuraman , Archunan Govindaraju
Published: March 2022

Bacterial extracellular proteins participate in the host cell communication by virtue of the modulation of pathogenicity, commensalism and mutualism. Studies on the microbiome of cervical mucus of the water buffalo (Bubalus bubalis) have shown the occurrence of Staphylococcus pasteuri and that the presence of this bacterium is indicative of various physiological and reproductive states in the host. Recently, S. pasteuri has been isolated from the cervical mucus of the buffalo during the different phases of estrous cycle, and has proved to be much more pronounced during the estrus phase. The basis underlying the availability of a significantly increased S. pasteuri population, specifically during the estrus phase, is not known. Consequently, it is important to determine the significance of the specific abundance of S. pasteuri during the estrus phase of the buffalo host, particularly from the perspective of whether this bacterial species is capable of contributing to sexual communication via its extracellular proteins and volatiles. Therefore, the relevance of S. pasteuri exoproteome in the buffalo cervical mucus during the estrus phase was analyzed using LC-MS/MS. As many as 219 proteins were identified, among which elongation factor Tu (EF-Tu), 60-kDa chaperonin (Cpn60), enolase, fructose-bisphosphate aldolase class 1 (FBP aldolase), enoyl-[acyl-carrier-protein] reductase [NADPH] (ENR) and lipoprotein (Lpp) were the functionally important candidates. Most of the proteins present in the exoproteome of S. pasteuri were those involved in cellular–metabolic functions, as well as catalytic- and binding activities. Moreover, computational studies of Lpp have shown enhanced interaction with volatiles such as acetic-, butanoic-, isovaleric- and valeric acids, which were identified in the cervical mucus S. pasteuri culture supernatant. The present findings suggest that S. pasteuri extracellular proteins may play an important role in buffalo sexual communication during the estrus phase.
New Insight in Hyperinsulinism/Hyperammonemia Syndrome by Magnetic Resonance Imaging and Spectroscopy
Authors: Gariani Karim , Klauser Antoine , Vargas Maria Isabel , Lazeyras François , Tran Christel
Published: March 2022

Hyperinsulinism/hyperammonemia syndrome (HI/HA) is an autosomal dominant disorder caused by monoallelic activating mutations in the glutamate dehydrogenase 1 (GLUD1) gene. While hyperinsulinism may be explained by a reduction in the allosteric inhibition of GLUD1, the pathogenesis of HA in HI/HA remains uncertain; interestingly, HA in the HI/HA syndrome is not associated with acute hyperammonemic intoxication events. We obtained a brain magnetic resonance (MR) in a woman with HI/HA syndrome with chronic asymptomatic HA. On MR spectroscopy, choline and myoinositol were decreased as in other HA disorders. In contrast, distinct from other HA disorders, combined glutamate and glutamine levels were normal (not increased). This observation suggests that brain biochemistry in HI/HA may differ from that of other HA disorders. In HI/HA, ammonia overproduction may come to the expense of glutamate levels, and this seems to prevent the condensation of ammonia with glutamate to produce glutamine that is typical of the other HA disorders. The absence of combined glutamate and glutamine elevation might be correlated to the absence of acute cerebral ammonia toxicity.
Comparison of Simulation and Measurement in a Short-Term Evaluation of the Thermal Comfort Parameters of an Office in a Low-Carbon Building
Authors: Ponechal Radoslav , Barňák Peter , Ďurica Pavol
Published: March 2022

The subject of the following analysis is the Research Centre building of the University of Zilina (RC UNIZA), which was purposely designed as a low-carbon project. The measurements of selected offices were carried out to verify how the building envelope and infill cooling system influences the indoor environment during the summer season. These measurements, along with the parameters of outdoor climate and its influence on the indoor thermal-humidity microclimate were monitored. Most of the data was then used in subsequent transient-state thermal simulation in an ESP-r program. The evaluation took two days to complete wherein an air-cooling system and ceiling radiant cooling were presented. The office during the test was not occupied and was therefore slightly cooler. Under these conditions (measured and simulated), PPD and PMV indexes were calculated during a 10 h time period with varying input parameters (metabolic heat and thermal resistance of clothing). According to the measurement and simulation, these indexes were compared. The comparison shows that the agreement depends on the chosen personal factors such as the thermal resistance of the clothing and metabolic heat. If these are chosen appropriately, then the differences between the results according to the measurement and the simulation were limited.