bluuebunny/crossref_metadata_2025 huggingface dataset:
Fast and semi-automatic S-wave and P-wave velocity estimations from landstreamer data: a field case from the Middle East
Authors: Pace Francesca , Khosro Anjom Farbod , Karimpour Mohammadkarim , Bolève Alexandre , Benboudiaf Yassine , Pournaki Hamed , Socco Laura Valentina
Published: April 2024

Seismic surface and body wave analyses are powerful tools for the geotechnical characterization of sites. The use of landstreamers facilitates the acquisition of dense data sets over large areas. However, efficient processing workflows are needed to estimate 3D velocity models from these massive data sets. For surface wave analysis, the manual picking of dispersion curves (DCs) of large data sets is very time-consuming, whereas the accuracy can be biased by operator choices. We apply a semi-automatic workflow for the analysis, processing, and interpretation of a large-scale landstreamer data set acquired for engineering purposes in the Middle East. The workflow involves the application of a validated automatic DC picking algorithm, and the transformation of the DCs into S- and P-wave velocity models through the wavelength-depth technique. The method has a high level of automation, is data driven and does not require extensive data inversion. Another remarkable benefit is that the auto-picking is more than 1,000 times more efficient than standard manual picking and the estimated velocities are in good agreement with available geotechnical and geophysical information. We conclude that the semi-automatic approach may represent a fast and straightforward method suitable for both research and industrial projects, thus enhancing further collaborations and developments.
The unique association between the level of plateletcrit and the prevalence of diabetic kidney disease: a cross-sectional study
Authors: Wei Shuwu , Pan Xinyu , Xiao Yao , Chen Ruishuang , Wei Junping
Published: April 2024

Objective

The activation of platelets in individuals with type 2 diabetes mellitus (T2DM) triggers inflammation and hemodynamic abnormalities, contributing to the development of diabetic kidney disease (DKD). Despite this, research into the relationship between plateletcrit (PCT) levels and DKD is sparse, with inconsistent conclusions drawn regarding the connection between various platelet parameters and DKD. This highlights the necessity for comprehensive, large-scale population studies. Therefore, our objective is to explore the association between PCT levels and various platelet parameters in relation to DKD.

Methods

In this cross-sectional study, hematological parameter data were collected from a cohort of 4,302 hospitalized Chinese patients. We analyzed the relationships between PCT, platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), platelet large cell ratio (P-LCR), and DKD, along with the urinary albumin-to-creatinine ratio (UACR), and estimated glomerular filtration rate (eGFR). Receiver operating characteristic (ROC) curve analysis was conducted to evaluate the diagnostic potential of these parameters.

Results

DKD patients exhibited significantly higher PCT levels compared to those without DKD. Multivariate regression analysis identified elevated PCT and PLT levels as potential independent risk factors for both DKD and UACR, while lower MPV levels might serve as independent protective factors for eGFR. The areas under the ROC curve for PCT in relation to DKD and UACR (≥30 mg/g) were 0.523 and 0.526, respectively. The area under the ROC curve for PLT in relation to UACR (≥30 mg/g) was 0.523.

Conclusion

PCT demonstrates a weak diagnostic value for T2DM patients at risk of developing DKD and experiencing proteinuria, and PLT shows a similarly modest diagnostic utility for detecting proteinuria. These insights contribute to a deeper understanding of the complex dynamics involved in DKD. Additionally, incorporating these markers into routine clinical assessments could enhance risk stratification, facilitating early interventions and personalized management strategies.
Group 2 innate lymphoid cells are key in lipid transfer protein allergy pathogenesis
Authors: Palomares Francisca , Pérez-Sánchez Natalia , Nieto Nazaret , Núñez Rafael , Cañas José Antonio , Martín-Astorga María del Carmen , Cruz-Amaya Anyith , Torres María José , Eguíluz-Gracia Ibon , Mayorga Cristobalina , Gómez Francisca
Published: April 2024

Background

Immunopathology in food allergy is characterized by an uncontrolled type 2 immune response and specific-IgE production. Recent studies have determined that group 2 innate lymphoid cells (ILC2) participate in the food allergy pathogenic mechanism and their severity. Our objective was to investigate the role of ILC2 in peach-allergic patients due to non-specific lipid transfer protein (Pru p 3) sensitization.

Methods

The immune response in peripheral blood mononuclear cells was characterized in lipid transfer protein-allergic patients and healthy controls. We have analyzed the Pru p 3 uptake on ILC2, the expression of costimulatory molecules, and their involvement on the T-cell proliferative response and cytokine production under different experimental conditions: cytokines involved in group 2 innate lymphoid cell activation (IL-33 and IL-25), Pru p 3 as main food allergen, and the combination of both components (IL-33/IL-25+Pru p 3) using cell sorting, EliSpot, flow cytometry, and confocal microscopy.

Results

Our results show that Pru p 3 allergen is taken up by group 2 innate lymphoid cells, regulating their costimulatory molecule expression (CD83 and HLA-DR) depending on the presence of Pru p 3 and its combination with IL-33/IL-25. The Pru p 3-stimulated ILC2 induced specific GATA3+Th2 proliferation and cytokine (IL-4, IL-5, and IL-13) production in lipid transfer protein-allergic patients in a cell contact-dependent manner with no changes in Tbet+Th1- and FOXP3+Treg cell differentiation.

Conclusions

The results indicate that in lipid transfer protein-allergic patients, the responsible allergen, Pru p 3, interacts with group 2 innate lymphoid cells, promoting a Th2 cell response. Our results might be of interest in vivo, as they show a role of group 2 innate lymphoid cells as antigen-presenting cells, contributing to the development of food allergy. Consequently, group 2 innate lymphoid cells may be considered as potential therapeutic targets.
Effect of 18F-DCFPyL PET on changes in management of patients with prostate cancer: a systematic review and meta-analysis
Authors: Wang Hui , Zhu HongMei , Li GuanNan , Dai JiaoNa , Huang HeXiao , Jia Qiong
Published: April 2024

Purpose

Prostate-specific membrane antigen (PSMA)-targeted imaging has gained increasing interest in its application in prostate cancer lesion detection. Compared with 68Galium (68Ga), 18Fluoride (18F)-labeled imaging agent has easier syntheses, lower price, and a longer half-time. 2-(3-{1-Carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid positron emission tomography (18F-DCFPyL PET) has been recently approved by the U.S. Food and Drug Administration. Several studies have proven its superiority to conventional imaging techniques in detecting prostate cancer lesions. However, the impact of 18F-DCFPyL PET on the management of patients with prostate cancer is not well established. Thus, we performed a systematic review and meta-analysis of available data to evaluate the impact of 18F-DCFPyL PET on the management of patients with prostate cancer.

Methods

The PubMed, Embase, Scopus, and Cochrane databases were searched up to April 2024. Studies that reported the proportion of changes in management after 18F-DCFPyL PET was performed in patients with prostate cancer were included. The Grading of Recommendations Assessment, Development, and Evaluation system was used for the quality evaluation of the included studies. The proportion of changes in management was pooled using a random effects model. Meta-regression analyses were performed to assess the potential correlation between the PET positivity and management changes.

Results

Fourteen studies (3,078 patients with prostate cancer) were included in our review and analysis. The pooled percentage of management changes was 43.5% (95% confidence interval [CI]: 33–54%). In patients with biochemical recurrent and for primary staging, the pooled percentage was 50% (95% CI: 39–60%) and 22% (95% CI: 15–29%), respectively. In the meta-regression analyses, PET positivity was detected as a significant predictor of management change (p = 0.0023).

Conclusion

18F-DCFPyL PET significantly affects the management of patients with prostate cancer. Higher PET positivity rate significantly correlated with a higher proportion of management changes in patients with prostate cancer. However, more studies are still needed to confirm the important role of 18F-DCFPyL PET in the management of prostate cancer.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO/#myprospero, CRD42022339178.
Aberrant brain topological organization and granger causality connectivity in Parkinson’s disease with impulse control disorders
Authors: Gan Caiting , Zhang Heng , Sun Huimin , Cao Xingyue , Wang Lina , Zhang Kezhong , Yuan Yongsheng
Published: April 2024

Introduction

Impulse control disorders (ICDs) refer to the common neuropsychiatric complication of Parkinson’s disease (PD). The white matter (WM) topological organization and its impact on brain networks remain to be established.

Methods

A total of 17 PD patients with ICD (PD-ICD), 17 without ICD (PD-NICD), and 18 healthy controls (HCs) were recruited. Graph theoretic analyses and Granger causality analyses were combined to investigate WM topological organization and the directional connection patterns of key regions.

Results

Compared to PD-NICD, ICD patients showed abnormal global properties, including decreased shortest path length (Lp) and increased global efficiency (Eg). Locally, the ICD group manifested abnormal nodal topological parameters predominantly in the left middle cingulate gyrus (MCG) and left superior cerebellum. Decreased directional connectivity from the left MCG to the right medial superior frontal gyrus was observed in the PD-ICD group. ICD severity was significantly correlated with Lp and Eg.

Discussion

Our findings reflected that ICD patients had excessively optimized WM topological organization, abnormally strengthened nodal structure connections within the reward network, and aberrant causal connectivity in specific cortical– limbic circuits. We hypothesized that the aberrant reward and motor inhibition circuit could play a crucial role in the emergence of ICDs.
The quality of life impacting factors in malnourished patients with gastric cancer
Authors: Zhao Hong , Liu Chenan , Ruan Guotian , Zheng Xin , Chen Yue , Lin Shiqi , Liu Xiaoyue , Shi Jinyu , Li Xiangrui , Li Shuqun , Shi Hanping
Published: April 2024

Introduction

Malnutrition is prevalent among individuals with gastric cancer and notably decreases their quality of life (QOL). However, the factors impacting QOL are yet to be clearly defined. This study aimed to identify essential factors impacting QOL in malnourished patients suffering from gastric cancer.

Methods

By using the Patient-Generated Subjective Global Assessment (PG-SGA) to assess the nutritional status (≥4 defined malnutrition) of hospitalized cancer patients, 4,586 gastric cancer patients were ultimately defined as malnourished. Spearman method was used to calculate the relationship between clinical features and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30). Then, univariate and multivariate logistic regression were used to observe which factors affected QOL, and subgroup analysis was performed in young and old population respectively. In addition, we used univariate and multivariate logistic regression to explore whether and how self-reported frequent symptoms in the last 2 weeks of the PG-SGA score affected QOL.

Results

In multivariate logistic regression analysis of clinical features of patients with malnourished gastric cancer, women, stage II, stage IV, WL had an independent correlation with a low global QOL scores. However, BMI, secondary education, higher education, surgery, chemotherapy, HGS had an independent correlation with a high global QOL scores. In multivariate logistic regression analysis of symptoms in self-reported PG-SGA scores in patients with malnourished gastric cancer, having no problem eating had an independent correlation with a high global QOL scores. However, they have no appetite, nausea, vomiting, constipation and pain had an independent correlation with a lower global QOL scores. The p values of the above statistical results are both < 0.05.

Conclusion

This study demonstrates that QOL in malnourished patients with gastric cancer is determined by female sex, stage II, stage IV, BMI, secondary and higher education or above, surgery, chemotherapy, WL, and HGS. Patients’ self-reported symptoms of nearly 2 weeks, obtained by using PG-SGA, are also further predictive of malnourished gastric cancer patients. Detecting preliminary indicators of low QOL could aid in identifying patients who might benefit from an early referral to palliative care and assisted nursing.
Metastatic organotropism: a brief overview
Authors: Carrolo Margarida , Miranda João A. I. , Vilhais Guilherme , Quintela António , Sousa Mário Fontes e , Costa Diogo Alpuim , Pinto Francisco R.
Published: April 2024

Organotropism has been known since 1889, yet this vital component of metastasis has predominantly stayed elusive. This mini-review gives an overview of the current understanding of the underlying mechanisms of organotropism and metastases development by focusing on the formation of the pre-metastatic niche, immune defenses against metastases, and genomic alterations associated with organotropism. The particular case of brain metastases is also addressed, as well as the impact of organotropism in cancer therapy. The limited comprehension of the factors behind organotropism underscores the necessity for efficient strategies and treatments to manage metastases.
Characteristics and spectrum changes of PICU cases during the COVID-19 pandemic: a retrospective analysis
Authors: Yang Yufan , He Yueqi , Huang Jiaotian , Yan Haipeng , Zhang Xinping , Xiao Zhenghui , Lu Xiulan
Published: April 2024

Objective

This study aims to compare the changes in the disease spectrum of children admitted to the Pediatric Intensive Care Units (PICU) during the COVID-19 pandemic with the three years prior to the pandemic, exploring the impact of the COVID-19 pandemic on the disease spectrum of PICU patients.

Methods

A retrospective analysis was conducted on critically ill children admitted to the PICU of Hunan Children's Hospital from January 2020 to December 2022, and the results were compared with cases from the same period between January 2017 and December 2019. The cases were divided into pre-pandemic period (January 2017–December 2019) with 8,218 cases, and pandemic period (January 2020–December 2022) with 5,619 cases. General characteristics, age, and gender were compared between the two groups.

Results

Compared to the pre-pandemic period, there was a 31.62% decrease in the number of admitted children during the pandemic period, and a 52.78% reduction in the proportion of respiratory system diseases. The overall mortality rate decreased by 87.81%. There were differences in age and gender distribution between the two periods. The length of hospital stay during the pandemic showed no statistical significance, whereas hospitalization costs exhibited statistical significance.

Conclusion

The COVID-19 pandemic has exerted a certain influence on the disease spectrum of PICU admissions. Implementing relevant measures during the pandemic can help reduce the occurrence of respiratory system diseases in children. Considering the changes in the disease spectrum of critically ill PICU children, future clinical prevention and treatment in PICUs should continue to prioritize the respiratory, neurological, and hematological oncology systems.
Inborn errors of immunity with susceptibility to S. aureus infections
Authors: Kurz Hannah , Lehmberg Kai , Farmand Susan
Published: April 2024

Staphylococcus aureus (S. aureus) is a significant human pathogen, in particular in patients with an underlying medical condition. It is equipped with a large variety of virulence factors enabling both colonization and invasive disease. The spectrum of manifestation is broad, ranging from superficial skin infections to life-threatening conditions like pneumonia and sepsis. As a major cause of healthcare-associated infections, there is a great need in understanding staphylococcal immunity and defense mechanisms. Patients with inborn errors of immunity (IEI) frequently present with pathological infection susceptibility, however, not all of them are prone to S. aureus infection. Thus, enhanced frequency or severity of S. aureus infections can serve as a clinical indicator of a specific underlying immunological impairment. In addition, the analysis of immunological functions in patients with susceptibility to S. aureus provides a unique opportunity of understanding the complex interplay between staphylococcal virulence and host immune predisposition. While the importance of quantitatively and qualitatively normal neutrophils is widely known, less awareness exists about the role of specific cytokines such as functional interleukin (IL)-6 signaling. This review categorizes well-known IEI in light of their susceptibility to S. aureus and discusses the relevant associated pathomechanisms. Understanding host-pathogen-interactions in S. aureus infections in susceptible individuals can pave the way for more effective management and preventive treatment options. Moreover, these insights might help to identify patients who should be screened for an underlying IEI. Ultimately, enhanced understanding of pathogenesis and immune responses in S. aureus infections may also be of relevance for the general population.
N-p-coumaroyloctopamine ameliorates hepatic glucose metabolism and oxidative stress involved in a PI3K/AKT/GSK3β pathway
Authors: Huang Yuechang , Zhang Xingmin , Li Qian , Zheng Wende , Wu Panpan , Wu Rihui , Chen Wen-Hua , Li Chen
Published: April 2024

Type 2 diabetes mellitus is regarded as a chronic metabolic disease characterized by hyperglycemia. Long-term hyperglycemia may result in oxidative stress, damage pancreatic β-cell function and induce insulin resistance. Herein we explored the anti-hypoglycemic effects and mechanisms of action of N-p-coumaroyloctopamine (N-p-CO) in vitro and in vivo. N-p-CO exhibited high antioxidant activity, as indicated by the increased activity of SOD, GSH and GSH-Px in HL-7702 cells induced by both high glucose (HG) and palmitic acid (PA). N-p-CO treatment significantly augmented glucose uptake and glycogen synthesis in HG/PA-treated HL-7702 cells. Moreover, administration of N-p-CO in diabetic mice induced by both high-fat diet (HFD) and streptozotocin (STZ) not only significantly increased the antioxidant levels of GSH-PX, SOD and GSH, but also dramatically alleviated hyperglycemia and hepatic glucose metabolism in a dose-dependent manner. More importantly, N-p-CO upregulated the expressions of PI3K, AKT and GSK3β proteins in both HG/PA-induced HL-7702 cells and HFD/STZ-induced mice. These findings clearly suggest that N-p-CO exerts anti-hypoglycemic and anti-oxidant effects, most probably via the regulation of a PI3K/AKT/GSK3β signaling pathway. Thus, N-p-CO may have high potentials as a new candidate for the prevention and treatment of diabetes.
Transient deoxyhemoglobin formation as a contrast for perfusion MRI studies in patients with brain tumors: a feasibility study
Authors: Stumpo Vittorio , Sayin Ece Su , Bellomo Jacopo , Sobczyk Olivia , van Niftrik Christiaan Hendrik Bas , Sebök Martina , Weller Michael , Regli Luca , Kulcsár Zsolt , Pangalu Athina , Bink Andrea , Duffin James , Mikulis David D. , Fisher Joseph A. , Fierstra Jorn
Published: April 2024

Background: Transient hypoxia-induced deoxyhemoglobin (dOHb) has recently been shown to represent a comparable contrast to gadolinium-based contrast agents for generating resting perfusion measures in healthy subjects. Here, we investigate the feasibility of translating this non-invasive approach to patients with brain tumors.

Methods: A computer-controlled gas blender was used to induce transient precise isocapnic lung hypoxia and thereby transient arterial dOHb during echo-planar-imaging acquisition in a cohort of patients with different types of brain tumors (n = 9). We calculated relative cerebral blood volume (rCBV), cerebral blood flow (rCBF), and mean transit time (MTT) using a standard model-based analysis. The transient hypoxia induced-dOHb MRI perfusion maps were compared to available clinical DSC-MRI.

Results: Transient hypoxia induced-dOHb based maps of resting perfusion displayed perfusion patterns consistent with underlying tumor histology and showed high spatial coherence to gadolinium-based DSC MR perfusion maps.

Conclusion: Non-invasive transient hypoxia induced-dOHb was well-tolerated in patients with different types of brain tumors, and the generated rCBV, rCBF and MTT maps appear in good agreement with perfusion maps generated with gadolinium-based DSC MR perfusion.
Low lung function in Bipolar Disorder and Schizophrenia: a hidden risk
Authors: Ruiz-Rull Cristina , Jaén-Moreno María José , del Pozo Gloria Isabel , Gómez Cristina , Montiel Francisco Javier , Alcántara Montserrat , Carrión Laura , Chauca Geli Marie , Feu Nuria , Guler Ipek , Rico-Villademoros Fernando , Camacho-Rodríguez Cristina , Gutierrez-Rojas Luis , Mannino David , Sarramea Fernando
Published: April 2024

Introduction: People with serious mental illness (SMI), such as schizophrenia and bipolar disorder, have a higher risk of premature morbidity and mortality. In the general population, impaired lung function is associated with increased morbidity and mortality. We compared lung function between people with and without serious mental illnesses using a cross-sectional study in 9 community mental health units.

Methods: Subjects aged 40–70 years with a diagnosis of schizophrenia or bipolar disorder were recruited consecutively. The controls had no psychiatric diagnosis and were not receiving any psychotropics. Spirometry was performed by a trained nurse. We used the 2021 American Thoracic Society/European Respiratory Society standards for the interpretation of the spirometry results.

Results: We studied 287 subjects. People with SMI (n = 169) had lower spirometry values than those without a psychiatric diagnosis (n = 118). An abnormal spirometry pattern (36.1% vs 16.9%, p < 0.001), possible restriction or non-specific (Preserved Ratio Impaired Spirometry [PRISm]) pattern (17.8% vs 7.6%, p = 0.014), and pattern of airflow obstruction or possible mixed disorder (18.3% vs 9.3%, p = 0.033) were more frequent in people with SMI. Multivariate analyses showed that the PRISm pattern was associated with abdominal circumference (odds ratio [OR] 1.05, 95%CI 1.03–1.08) and that the pattern of airflow obstruction or possible mixed disorder was associated with smoking behavior (OR 5.15, 95%CI 2.06–15.7).

Conclusion: People with SMI have impaired lung function, with up to one-third of them showing an abnormal spirometry pattern. This suggests that regular monitoring of lung function and addressing modifiable risk factors, such as tobacco use and obesity, in this population is of paramount importance.
Framework proposal for Role-Playing Games as mental health intervention: the Critical Skills methodology
Authors: Otani Victor Henrique Oyamada , Novaes Rafael A. C. B. , Pedron Julia , Nabhan Pedro Chen , Rodrigues Thaísa Malbar , Chiba Ryo , Guedes João Vitor Cardoso , Marques Lucas Murrins , Vissoci João Ricardo Nickenig
Published: April 2024

Gamified interventions are an emerging approach in mental health treatment and prevention. Their positive effects on managing various clinical conditions stem from enhancing social skills. However, cost-effective options like Table-top Role-Playing Games (TTRPGs), which offer similar benefits to other game-based interventions, lack standardized methods for ensuring replicability. In this regard, the method outlined in this study endeavors, in a structured and guided manner drawing from the Consolidated Framework for Implementation Research (CFIR), to establish a six-step protocol for developing an intervention method utilizing TTRPGs. In all Steps, we aim to anchor ourselves in robust literature concerning social skills training (SST), cognitive behavioral therapy (CBT), and gamification comprehensively. Thus, the method presented encompasses the objectives of SST, the strategies of CBT, and the dynamics of gamification via TTRPGs. Furthermore, we demonstrate a possible application of the method to illustrate its feasibility. Ultimately, the final method is structured, evidence-based, easily applicable, cost-effective, and thus viable. Mental health professionals seeking a structured and instructional tool for protocol development will find support in the method proposed here.
Neuroplasticity of children in autism spectrum disorder
Authors: Chen Zilin , Wang Xu , Zhang Si , Han Fei
Published: April 2024

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that encompasses a range of symptoms including difficulties in verbal communication, social interaction, limited interests, and repetitive behaviors. Neuroplasticity refers to the structural and functional changes that occur in the nervous system to adapt and respond to changes in the external environment. In simpler terms, it is the brain’s ability to learn and adapt to new environments. However, individuals with ASD exhibit abnormal neuroplasticity, which impacts information processing, sensory processing, and social cognition, leading to the manifestation of corresponding symptoms. This paper aims to review the current research progress on ASD neuroplasticity, focusing on genetics, environment, neural pathways, neuroinflammation, and immunity. The findings will provide a theoretical foundation and insights for intervention and treatment in pediatric fields related to ASD.
Influencing factors of hospitalization cost of hypertension patients in traditional Chinese medicine hospitals
Authors: Hou Hao-jia , Cong Tian-zhen , Cai Yu , Ba Ya-hui , Chen Meng-en , Yang Jing-yu , Luo Zhong-hua
Published: April 2024

Objectives

This study aimed to analyze the influencing factors of hospitalization cost of hypertensive patients in TCM (traditional Chinese medicine, TCM) hospitals, which can provide a scientific basis for hospitals to control the hospitalization cost of hypertension.

Methods

In this study, 3,595 hospitalized patients with a primary diagnosis of tertiary hypertension in Tianshui City Hospital of TCM, Gansu Province, China, from January 2017 to June 2022, were used as research subjects. Using univariate analysis to identify the relevant variables of hospitalization cost, followed by incorporating the statistically significant variables of univariate analysis as independent variables in multiple linear regression analysis, and establishing the path model based on the results of the multiple linear regression finally, to explore the factors influencing hospitalization cost comprehensively.

Results

The results showed that hospitalization cost of hypertension patients were mainly influenced by length of stay, age, admission pathways, payment methods of medical insurance, and visit times, with length of stay being the most critical factor.

Conclusion

The Chinese government should actively exert the characteristics and advantages of TCM in the treatment of chronic diseases such as hypertension, consistently optimize the treatment plans of TCM, effectively reduce the length of stay and steadily improve the health literacy level of patients, to alleviate the illnesses pain and reduce the economic burden of patients.
Bidding strategies for multi-microgrid markets taking into account risk indicators
Authors: Lv Xiangyv , Qi Chenglong , Ji Xiu , Yv Jiqing , Wang Hui , Han Huanhuan
Published: April 2024

A large proportion of new energy generation is integrated into the power grid, making it difficult for the power grid system to maintain reliable, stable, and efficient operation. To address these challenges, this article proposes a multiple microgrid hierarchical optimization structure based on energy routers as the core equipment for energy regulation within microgrids. Considering the uncertainty of renewable energy generation within microgrids, a two-layer energy management bidding strategy based on risk indicators is further proposed. In the process of trading, with the goal of maximizing a comprehensive economy, the energy trading model of the distribution network center and energy routers is divided into two sub-objectives for solving. In the first stage, based on the interests and energy supply and demand relationships of each microgrid, a risk assessment model considering wind and solar uncertainty is established to determine the risk preferences and expected returns of each microgrid. In the second stage, the original problem is decomposed into two sub-problems: the minimum cost sub-problem and the maximum transaction volume sub-problem. An asymmetric bargaining mechanism is adopted to determine the production and sales payment of the microgrid containing energy routers based on the contribution values of energy routers in each microgrid. Finally, the rationality and effectiveness of energy routers as an intelligent decision-maker in energy optimization are verified in a three-node system.
Characterization of the vastus lateralis torque-length, and knee extensors torque-velocity and power-velocity relationships in people with Parkinson's disease
Authors: Magris Riccardo , Nardello Francesca , Bombieri Federica , Monte Andrea , Zamparo Paola
Published: April 2024

Introduction

Parkinson's disease (PD) is a prevalent neurodegenerative condition observed primarily in the elderly population that gives rise to motor and non-motor symptoms, one of which is muscle weakness. The aim of this study was to characterize the vastus lateralis torque-fascicle length (T-L) and the knee extensors torque-angular velocity (T-V) and power-angular velocity (P-V) relationships in PD patients and to investigate the influence of muscle geometry on muscle mechanics.

Methods

Participants (11 PD: patients, 9 CR: age matched healthy controls; 10 CY: young healthy controls) performed: (i) isometric contractions (e.g., MVC) to obtain the torque-angle and T-L relationships; (ii) isokinetic (e.g., iso-velocity) contractions to obtain the T-V and P-V relationships. During the experiments, the architecture of vastus lateralis (pennation angle, fascicle length, muscle thickness) was also determined by using an ultrasound apparatus.

Results

Significant differences were observed between PD patients and physically matched control groups (CR and CY) in terms of maximum isometric force (calculated as the apex of the T-L curve) and maximum mechanical power (apex of the P-V curve), but not in maximum shortening velocity. Among the mechanical variables investigated, mechanical power was able to identify differences between the less and the more affected side in PD patients, suggesting that this parameter could be useful for clinical evaluation in this population.

Conclusions

The observed results cannot be explained by differences in muscle geometry at rest (similar in the three cohorts), but rather by the muscle capacity to change in shape during contraction, that is impaired in PD patients.
Potential imbalanced differences of grain production in the sustainable development of county cities—a case study of Jiangsu Province
Authors: Li Xiaoming , Xu Jinhai , Guo Zheng , Li Xin , Jin Tao , Lu Jieqiong , Li Tianrui
Published: April 2024

Introduction

Grain production at the regional level is related to the strategic development orientation of the country as a whole, and maintaining the stability of grain production is of great importance in ensuring the sustainable development of the food system. Studying the potential imbalance differences resulting from the spatial and temporal development of grain production and its driving factors will help to reduce the contradiction between the rapid development of the urban economy and the inappropriate use of arable land resources, thus coordinating regional agricultural development and further clarifying the direction and focus of future food security construction work.

Methods

This study focuses on the potential imbalance differences based on spatial and temporal development of grain production in Jiangsu Province during the period 1990–2020, and explores the spatial and temporal patterns and driving mechanisms of grain production spatial autocorrelation model and spatial error model are applied to analysis the spatial and temporal characteristics of grain production and security in Jiangsu Province and their influencing factors.

Results

The results are as follows: (1) The total amount of food in Jiangsu Province increased by 17.36% during the 30-year period, but the growth rate was lower than the national average. (2) Regional differences are significant, with a significant decline in grain production in southern Jiangsu and growth in northern and central Jiangsu. (3) The center of gravity for grain production has shifted to northern Jiangsu. (4) Grain production is significantly correlated with socio-economic factors such as per capita ownership, sown area, irrigated area, and cultivated area.

Discussion

To ensure the sustainability of food production in the future, attention should be paid to the risk of imbalance in regional food production, coordination of socio-economic factors, promotion of efficient agricultural production, improvement of the relevant policy system and optimization of the food production system.
Increasing Population Status of Broad-Snouted Caiman (Caiman latirostris) Based on Sustainable Use Strategies in a Managed Protected Area in Santa Fe, Argentina
Authors: Siroski Pablo Ariel , Ciocan Hernán , Hilevski Samuel , Larriera Alejandro
Published: April 2024

People and crocodilians have engaged in interactions since the earliest human settlements. After many years of escalating non-regulated use, coupled with emerging threats such as habitat modification, environmental pollution, and the exponential growth of human populations, natural crocodilian populations have been pushed to the brink of extinction. To prevent this, various initiatives have implemented strategies to prevent local extinction. Reinforcing wild populations through reintroductions and head-starting programs has been considered the safest approach to recovering crocodilian populations. Subsequently, the concept of sustainability emerged. In the case of many historically exploited crocodilian species, it became evident that rational utilization need not adversely affect population status; on the contrary, there were clear signs of recovery when local communities were involved. In 1990, the broad-snouted caiman (Caiman latirostris) was in a critical state due to decades of poaching and the aforementioned threats. In response, the “Monitoring and restocking program of the broad-snouted caiman for management purposes”, commonly known as Proyecto Yacaré, was established to study population abundance and assess the biological, ecological, and social response to this management methodology. As a result of the eggs’s harvest, a proportion equivalent to or greater than what would have survived in natural conditions was released into the original habitat where the eggs were collected. The surplus was allocated for leather and meat production with a focus on economic and environmentally sustainable practices, without affecting biodiversity or threats to the managed species. The in situ work carried out by this program has been crucial for the recovery of broad-snouted caiman populations under the “incentives for conservation” system, whereby local communities receive benefits for nest identification and egg harvesting. Over time, conservation incentives have become significant contributors to regional economies. This study illustrates how C. latirostris populations increased due to the implementation of egg harvesting by local communities in a natural reserve for management purposes. This population increase was detected through continuous night monitoring and an analysis of the number of nests in the area. Currently, C. latirostris populations have transitioned from being among the most threatened to becoming one of the most abundant throughout their distribution area. Based on the analyzed information, we may affirm that the commercial value of these species is one of the most relevant aspects contributing to the sustainability of these programs, primarily due to the change in perception generated among local communities. Therefore, identifying and controlling factors affecting these programs are fundamental for the conservation of these species.
Differential Gene Expression in Porcine Lung Compartments after Experimental Infection with Mycoplasma hyopneumoniae
Authors: Rosales Rubén S. , Risco David , García-Nicolás Obdulio , Pallarés Francisco J. , Ramírez Ana S. , Poveda José B. , Nicholas Robin A. J. , Salguero Francisco J.
Published: April 2024

Mycoplasma hyopneumoniae (Mhyo) is the causative agent of porcine enzootic pneumonia (EP), as well as one of the main pathogens involved in the porcine respiratory disease complex. The host–pathogen interaction between Mhyo and infected pigs is complex and not completely understood; however, improving the understanding of these intricacies is essential for the development of effective control strategies of EP. In order to improve our knowledge about this interaction, laser-capture microdissection was used to collect bronchi, bronchi-associated lymphoid tissue, and lung parenchyma from animals infected with different strains of Mhyo, and mRNA expression levels of different molecules involved in Mhyo infection (ICAM1, IL-8, IL-10, IL-23, IFN-α, IFN-γ, TGF-β, and TNF-α) were analyzed by qPCR. In addition, the quantification of Mhyo load in the different lung compartments and the scoring of macroscopic and microscopic lung lesions were also performed. Strain-associated differences in virulence were observed, as well as the presence of significant differences in expression levels of cytokines among lung compartments. IL-8 and IL-10 presented the highest upregulation, with limited differences between strains and lung compartments. IFN-α was strongly downregulated in BALT, implying a relevant role for this cytokine in the immunomodulation associated with Mhyo infections. IL-23 was also upregulated in all lung compartments, suggesting the potential involvement of a Th17-mediated immune response in Mhyo infections. Our findings highlight the relevance of Th1 and Th2 immune response in cases of EP, shedding light on the gene expression levels of key cytokines in the lung of pigs at a microscopic level.
Pseudomonas aeruginosa Infections in Patients with Severe COVID-19 in Intensive Care Units: A Retrospective Study
Authors: Baudet Alexandre , Regad Marie , Gibot Sébastien , Conrath Élodie , Lizon Julie , Demoré Béatrice , Florentin Arnaud
Published: April 2024

Patients hospitalized in ICUs with severe COVID-19 are at risk for developing hospital-acquired infections, especially infections caused by Pseudomonas aeruginosa. We aimed to describe the evolution of P. aeruginosa infections in ICUs at CHRU-Nancy (France) in patients with severe COVID-19 during the three initial waves of COVID-19. The second aims were to analyze P. aeruginosa resistance and to describe the antibiotic treatments. We conducted a retrospective cohort study among adult patients who were hospitalized for acute respiratory distress syndrome due to COVID-19 and who developed a hospital-acquired infection caused by P. aeruginosa during their ICU stay. Among the 51 patients included, most were male (90%) with comorbidities (77%), and the first identification of P. aeruginosa infection occurred after a median ICU stay of 11 days. Several patients acquired infections with MDR (27%) and XDR (8%) P. aeruginosa strains. The agents that strains most commonly exhibited resistance to were penicillin + β-lactamase inhibitors (59%), cephalosporins (42%), monobactams (32%), and carbapenems (27%). Probabilistic antibiotic treatment was prescribed for 49 patients (96%) and was subsequently adapted for 51% of patients after antibiogram and for 33% of patients after noncompliant antibiotic plasma concentration. Hospital-acquired infection is a common and life-threatening complication in critically ill patients. Efforts to minimize the occurrence and improve the treatment of such infections, including infections caused by resistant strains, must be pursued.
A Novel Protocol Using Captive Portals for FIDO2 Network Authentication
Authors: Rivera-Dourado Martiño , Gestal Marcos , Pazos Alejandro , Vázquez-Naya Jose
Published: April 2024

FIDO2 authentication is starting to be applied in numerous web authentication services, aiming to replace passwords and their known vulnerabilities. However, this new authentication method has not been integrated yet with network authentication systems. In this paper, we introduce FIDO2CAP: FIDO2 Captive-portal Authentication Protocol. Our proposal describes a novel protocol for captive-portal network authentication using FIDO2 Authenticators as security keys and passkeys. For validating our proposal, we have developed a prototype of FIDO2CAP authentication in a mock scenario. Using this prototype, we performed a usability experiment with 15 real users. This work makes the first systematic approach for adapting network authentication to the new authentication paradigm relying on FIDO2 authentication.
A New Data Processing Approach for the SHPB Test Based on PSO-TWER
Authors: Wang Xuesong , Xu Zhenyang , Guo Lianjun
Published: April 2024

This study addresses the challenge of accurately determining the arrival time of stress wave signals in SHPB test data processing. To eliminate human error, we introduce the time-window energy ratio method and evaluate six filters for noise reduction using box fractal dimensions. A mathematical model is established to optimize the stress equilibrium and impact process, which is solved using particle swarm optimization, resulting in the PSO-TWER method. We explore the impact of inertia weight and calculation methods on optimization outcomes, defining a stress equilibrium evaluation index. The results indicate that time-window length significantly affects arrival-time outputs, and the dynamic inertia weight factor enhances optimization convergence. The method accurately determines arrival times and effectively screens test data, providing a robust approach for SHPB test data processing.
Exploring the Effect of Moisture on CO2 Diffusion and Particle Cementation in Carbonated Steel Slag
Authors: Lin Shenqiu , Chen Ping , Xiang Weiheng , Hu Cheng , Li Fangbin , Liu Jun , Ding Yu
Published: April 2024

The study of the mechanisms affecting the preparation parameters of carbonated steel slag is of great significance for the development of carbon sequestration materials. In order to elucidate the mechanism of the influence of moisture on CO2 diffusion and particle cementation in steel slag, the effects of different water–solid ratios and water contents on the mechanical properties, carbonation products, and pore structure of steel slag after carbonation were investigated. The results show that increasing the water–solid ratio of steel slag can control the larger initial porosity and improve the carbon sequestration capacity of steel slag, but it will reduce the mechanical properties. The carbonation process relies on pores for CO2 diffusion and also requires a certain level of moisture for Ca2+ dissolution and diffusion. Increasing the water content enhances particle cementation and carbonation capacity in steel slag specimens; however, excessive water hinders CO2 diffusion. Reducing the water content can increase the carbonation depth but may compromise gelling and carbon sequestration ability. Therefore, achieving a balance is crucial in controlling the water content. The compressive strength of the steel slag with suitable moisture and initial porosity can reach 118.7 MPa, and 217.2 kg CO2 eq./t steel slag can be sequestered.
Challenges and Opportunities for Pilot Scaling-Up Extraction of Olive Oil Assisted by Pulsed Electric Fields: Process, Product, and Economic Evaluation
Authors: Dias Sara , Pino-Hernández Enrique , Gonçalves Diogo , Rego Duarte , Redondo Luís , Alves Marco
Published: April 2024

This study aimed to investigate the impact of Pulsed Electric Fields (PEF) technology in the extraction of olive oil on a pilot scale, using the “Galega Vulgar” olive variety as raw material. The extraction assisted by PEF had a malaxation time of 30 min and was compared with the traditional process of 45 min of malaxation. The main quality parameters of olive oil and the PEF’s cost-benefit assessment were performed. The incorporation of PEF in olive oil production reduced the malaxation stage by 33% without compromising the yield or extra-virgin classification. This efficiency leads to a potential 12.3% increase in annual olive oil production, with a 12.3% and 36.8% rise in revenue and gross profit, respectively. For small-scale production, the considerable upfront investment required for PEF equipment may be a challenge in terms of return on investment. In this scenario, opting for a renting scheme is the best economic solution, especially given the seasonal nature of olive oil production. In medium- to large-scale production, the investment in PEF is a sound investment since it is possible to achieve, with an equipment cost of EUR 450,000 and a production output of 5 tons per hour, an annual ROI of 20%.
Efficient Optimization of a Support Vector Regression Model with Natural Logarithm of the Hyperbolic Cosine Loss Function for Broader Noise Distribution
Authors: Kocaoğlu Aykut
Published: April 2024

While traditional support vector regression (SVR) models rely on loss functions tailored to specific noise distributions, this research explores an alternative approach: ε-ln SVR, which uses a loss function based on the natural logarithm of the hyperbolic cosine function (lncosh). This function exhibits optimality for a broader family of noise distributions known as power-raised hyperbolic secants (PHSs). We derive the dual formulation of the ε-ln SVR model, which reveals a nonsmooth, nonlinear convex optimization problem. To efficiently overcome these complexities, we propose a novel sequential minimal optimization (SMO)-like algorithm with an innovative working set selection (WSS) procedure. This procedure exploits second-order (SO)-like information by minimizing an upper bound on the second-order Taylor polynomial approximation of consecutive loss function values. Experimental results on benchmark datasets demonstrate the effectiveness of both the ε-ln SVR model with its lncosh loss and the proposed SMO-like algorithm with its computationally efficient WSS procedure. This study provides a promising tool for scenarios with different noise distributions, extending beyond the commonly assumed Gaussian to the broader PHS family.